                         SEQUENCE LISTING

<110>  The Regents of the University of California
       The Trustees of Princeton University
       The Simons Foundation, Inc.
       Lim, Wendell A.
       Troyanskaya, Olga G.
       VanderSluis, Benjamin
       Dannenfelser, Ruth
 
<120>  SYSTEMS AND METHODS FOR TARGETING CANCER CELLS

<130>  UCSF-537WO

<150>  US 62/333,106
<151>  2016-05-06

<160>  7475  

<170>  PatentIn version 3.5

<210>  1
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Ile Glu Ala Tyr Phe Glu Arg Ile Gly Tyr Lys Asn Ser Arg 
1               5                   10                  15      


Asn Lys Leu Asp Leu Glu Thr Leu Thr Asp Ile Leu Glu His Gln Ile 
            20                  25                  30          


Arg Ala Val Pro Phe Glu Asn Leu Asn Met His Cys Gly Gln Ala Met 
        35                  40                  45              


Glu Leu Gly Leu Glu Ala Ile Phe Asp His Ile Val Arg Arg Asn Arg 
    50                  55                  60                  


Gly Gly Trp Cys Leu Gln Val Asn Gln Leu Leu Tyr Trp Ala Leu Thr 
65                  70                  75                  80  


Thr Ile Gly Phe Gln Thr Thr Met Leu Gly Gly Tyr Phe Tyr Ile Pro 
                85                  90                  95      


Pro Val Asn Lys Tyr Ser Thr Gly Met Val His Leu Leu Leu Gln Val 
            100                 105                 110         


Thr Ile Asp Gly Arg Asn Tyr Ile Val Asp Ala Gly Ser Gly Ser Ser 
        115                 120                 125             


Ser Gln Met Trp Gln Pro Leu Glu Leu Ile Ser Gly Lys Asp Gln Pro 
    130                 135                 140                 


Gln Val Pro Cys Ile Phe Cys Leu Thr Glu Glu Arg Gly Ile Trp Tyr 
145                 150                 155                 160 


Leu Asp Gln Ile Arg Arg Glu Gln Tyr Ile Thr Asn Lys Glu Phe Leu 
                165                 170                 175     


Asn Ser His Leu Leu Pro Lys Lys Lys His Gln Lys Ile Tyr Leu Phe 
            180                 185                 190         


Thr Leu Glu Pro Arg Thr Ile Glu Asp Phe Glu Ser Met Asn Thr Tyr 
        195                 200                 205             


Leu Gln Thr Ser Pro Thr Ser Ser Phe Ile Thr Thr Ser Phe Cys Ser 
    210                 215                 220                 


Leu Gln Thr Pro Glu Gly Val Tyr Cys Leu Val Gly Phe Ile Leu Thr 
225                 230                 235                 240 


Tyr Arg Lys Phe Asn Tyr Lys Asp Asn Thr Asp Leu Val Glu Phe Lys 
                245                 250                 255     


Thr Leu Thr Glu Glu Glu Val Glu Glu Val Leu Arg Asn Ile Phe Lys 
            260                 265                 270         


Ile Ser Leu Gly Arg Asn Leu Val Pro Lys Pro Gly Asp Gly Ser Leu 
        275                 280                 285             


Thr Ile 
    290 


<210>  2
<211>  503
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Leu Gly Ser Pro Arg Lys Gly Leu Leu Met Leu Leu Met Ala 
1               5                   10                  15      


Leu Val Thr Gln Gly Asp Pro Val Lys Pro Ser Arg Gly Pro Leu Val 
            20                  25                  30          


Thr Cys Thr Cys Glu Ser Pro His Cys Lys Gly Pro Thr Cys Arg Gly 
        35                  40                  45              


Ala Trp Cys Thr Val Val Leu Val Arg Glu Glu Gly Arg His Pro Gln 
    50                  55                  60                  


Glu His Arg Gly Cys Gly Asn Leu His Arg Glu Leu Cys Arg Gly Arg 
65                  70                  75                  80  


Pro Thr Glu Phe Val Asn His Tyr Cys Cys Asp Ser His Leu Cys Asn 
                85                  90                  95      


His Asn Val Ser Leu Val Leu Glu Ala Thr Gln Pro Pro Ser Glu Gln 
            100                 105                 110         


Pro Gly Thr Asp Gly Gln Leu Ala Leu Ile Leu Gly Pro Val Leu Ala 
        115                 120                 125             


Leu Leu Ala Leu Val Ala Leu Gly Val Leu Gly Leu Trp His Val Arg 
    130                 135                 140                 


Arg Arg Gln Glu Lys Gln Arg Gly Leu His Ser Glu Leu Gly Glu Ser 
145                 150                 155                 160 


Ser Leu Ile Leu Lys Ala Ser Glu Gln Gly Asp Ser Met Leu Gly Asp 
                165                 170                 175     


Leu Leu Asp Ser Asp Cys Thr Thr Gly Ser Gly Ser Gly Leu Pro Phe 
            180                 185                 190         


Leu Val Gln Arg Thr Val Ala Arg Gln Val Ala Leu Val Glu Cys Val 
        195                 200                 205             


Gly Lys Gly Arg Tyr Gly Glu Val Trp Arg Gly Leu Trp His Gly Glu 
    210                 215                 220                 


Ser Val Ala Val Lys Ile Phe Ser Ser Arg Asp Glu Gln Ser Trp Phe 
225                 230                 235                 240 


Arg Glu Thr Glu Ile Tyr Asn Thr Val Leu Leu Arg His Asp Asn Ile 
                245                 250                 255     


Leu Gly Phe Ile Ala Ser Asp Met Thr Ser Arg Asn Ser Ser Thr Gln 
            260                 265                 270         


Leu Trp Leu Ile Thr His Tyr His Glu His Gly Ser Leu Tyr Asp Phe 
        275                 280                 285             


Leu Gln Arg Gln Thr Leu Glu Pro His Leu Ala Leu Arg Leu Ala Val 
    290                 295                 300                 


Ser Ala Ala Cys Gly Leu Ala His Leu His Val Glu Ile Phe Gly Thr 
305                 310                 315                 320 


Gln Gly Lys Pro Ala Ile Ala His Arg Asp Phe Lys Ser Arg Asn Val 
                325                 330                 335     


Leu Val Lys Ser Asn Leu Gln Cys Cys Ile Ala Asp Leu Gly Leu Ala 
            340                 345                 350         


Val Met His Ser Gln Gly Ser Asp Tyr Leu Asp Ile Gly Asn Asn Pro 
        355                 360                 365             


Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Gln 
    370                 375                 380                 


Ile Arg Thr Asp Cys Phe Glu Ser Tyr Lys Trp Thr Asp Ile Trp Ala 
385                 390                 395                 400 


Phe Gly Leu Val Leu Trp Glu Ile Ala Arg Arg Thr Ile Val Asn Gly 
                405                 410                 415     


Ile Val Glu Asp Tyr Arg Pro Pro Phe Tyr Asp Val Val Pro Asn Asp 
            420                 425                 430         


Pro Ser Phe Glu Asp Met Lys Lys Val Val Cys Val Asp Gln Gln Thr 
        435                 440                 445             


Pro Thr Ile Pro Asn Arg Leu Ala Ala Asp Pro Val Leu Ser Gly Leu 
    450                 455                 460                 


Ala Gln Met Met Arg Glu Cys Trp Tyr Pro Asn Pro Ser Ala Arg Leu 
465                 470                 475                 480 


Thr Ala Leu Arg Ile Lys Lys Thr Leu Gln Lys Ile Ser Asn Ser Pro 
                485                 490                 495     


Glu Lys Pro Lys Val Ile Gln 
            500             


<210>  3
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Thr Glu Leu Pro Ala Pro Leu Ser Tyr Phe Gln Asn Ala Gln Met 
1               5                   10                  15      


Ser Glu Asp Asn His Leu Ser Asn Thr Val Arg Ser Gln Asn Asp Asn 
            20                  25                  30          


Arg Glu Arg Gln Glu His Asn Asp Arg Arg Ser Leu Gly His Pro Glu 
        35                  40                  45              


Pro Leu Ser Asn Gly Arg Pro Gln Gly Asn Ser Arg Gln Val Val Glu 
    50                  55                  60                  


Gln Asp Glu Glu Glu Asp Glu Glu Leu Thr Leu Lys Tyr Gly Ala Lys 
65                  70                  75                  80  


His Val Ile Met Leu Phe Val Pro Val Thr Leu Cys Met Val Val Val 
                85                  90                  95      


Val Ala Thr Ile Lys Ser Val Ser Phe Tyr Thr Arg Lys Asp Gly Gln 
            100                 105                 110         


Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr Glu Thr Val Gly Gln Arg 
        115                 120                 125             


Ala Leu His Ser Ile Leu Asn Ala Ala Ile Met Ile Ser Val Ile Val 
    130                 135                 140                 


Val Met Thr Ile Leu Leu Val Val Leu Tyr Lys Tyr Arg Cys Tyr Lys 
145                 150                 155                 160 


Val Ile His Ala Trp Leu Ile Ile Ser Ser Leu Leu Leu Leu Phe Phe 
                165                 170                 175     


Phe Ser Phe Ile Tyr Leu Gly Glu Val Phe Lys Thr Tyr Asn Val Ala 
            180                 185                 190         


Val Asp Tyr Ile Thr Val Ala Leu Leu Ile Trp Asn Phe Gly Val Val 
        195                 200                 205             


Gly Met Ile Ser Ile His Trp Lys Gly Pro Leu Arg Leu Gln Gln Ala 
    210                 215                 220                 


Tyr Leu Ile Met Ile Ser Ala Leu Met Ala Leu Val Phe Ile Lys Tyr 
225                 230                 235                 240 


Leu Pro Glu Trp Thr Ala Trp Leu Ile Leu Ala Val Ile Ser Val Tyr 
                245                 250                 255     


Asp Leu Val Ala Val Leu Cys Pro Lys Gly Pro Leu Arg Met Leu Val 
            260                 265                 270         


Glu Thr Ala Gln Glu Arg Asn Glu Thr Leu Phe Pro Ala Leu Ile Tyr 
        275                 280                 285             


Ser Ser Thr Met Val Trp Leu Val Asn Met Ala Glu Gly Asp Pro Glu 
    290                 295                 300                 


Ala Gln Arg Arg Val Ser Lys Asn Ser Lys Tyr Asn Ala Glu Ser Thr 
305                 310                 315                 320 


Glu Arg Glu Ser Gln Asp Thr Val Ala Glu Asn Asp Asp Gly Gly Phe 
                325                 330                 335     


Ser Glu Glu Trp Glu Ala Gln Arg Asp Ser His Leu Gly Pro His Arg 
            340                 345                 350         


Ser Thr Pro Glu Ser Arg Ala Ala Val Gln Glu Leu Ser Ser Ser Ile 
        355                 360                 365             


Leu Ala Gly Glu Asp Pro Glu Glu Arg Gly Val Lys Leu Gly Leu Gly 
    370                 375                 380                 


Asp Phe Ile Phe Tyr Ser Val Leu Val Gly Lys Ala Ser Ala Thr Ala 
385                 390                 395                 400 


Ser Gly Asp Trp Asn Thr Thr Ile Ala Cys Phe Val Ala Ile Leu Ile 
                405                 410                 415     


Gly Leu Cys Leu Thr Leu Leu Leu Leu Ala Ile Phe Lys Lys Ala Leu 
            420                 425                 430         


Pro Ala Leu Pro Ile Ser Ile Thr Phe Gly Leu Val Phe Tyr Phe Ala 
        435                 440                 445             


Thr Asp Tyr Leu Val Gln Pro Phe Met Asp Gln Leu Ala Phe His Gln 
    450                 455                 460                 


Phe Tyr Ile 
465         


<210>  4
<211>  387
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Glu Thr Leu Phe Trp Thr Pro Leu Leu Val Val Leu Leu Ala 
1               5                   10                  15      


Gly Leu Gly Asp Thr Glu Ala Gln Gln Thr Thr Leu His Pro Leu Val 
            20                  25                  30          


Gly Arg Val Phe Val His Thr Leu Asp His Glu Thr Phe Leu Ser Leu 
        35                  40                  45              


Pro Glu His Val Ala Val Pro Pro Ala Val His Ile Thr Tyr His Ala 
    50                  55                  60                  


His Leu Gln Gly His Pro Asp Leu Pro Arg Trp Leu Arg Tyr Thr Gln 
65                  70                  75                  80  


Arg Ser Pro His His Pro Gly Phe Leu Tyr Gly Ser Ala Thr Pro Glu 
                85                  90                  95      


Asp Arg Gly Leu Gln Val Ile Glu Val Thr Ala Tyr Asn Arg Asp Ser 
            100                 105                 110         


Phe Asp Thr Thr Arg Gln Arg Leu Val Leu Glu Ile Gly Asp Pro Glu 
        115                 120                 125             


Gly Pro Leu Leu Pro Tyr Gln Ala Glu Phe Leu Val Arg Ser His Asp 
    130                 135                 140                 


Ala Glu Glu Val Leu Pro Ser Thr Pro Ala Ser Arg Phe Leu Ser Ala 
145                 150                 155                 160 


Leu Gly Gly Leu Trp Glu Pro Gly Glu Leu Gln Leu Leu Asn Val Thr 
                165                 170                 175     


Ser Ala Leu Asp Arg Gly Gly Arg Val Pro Leu Pro Ile Glu Gly Arg 
            180                 185                 190         


Lys Glu Gly Val Tyr Ile Lys Val Gly Ser Ala Ser Pro Phe Ser Thr 
        195                 200                 205             


Cys Leu Lys Met Val Ala Ser Pro Asp Ser His Ala Arg Cys Ala Gln 
    210                 215                 220                 


Gly Gln Pro Pro Leu Leu Ser Cys Tyr Asp Thr Leu Ala Pro His Phe 
225                 230                 235                 240 


Arg Val Asp Trp Cys Asn Val Thr Leu Val Asp Lys Ser Val Pro Glu 
                245                 250                 255     


Pro Ala Asp Glu Val Pro Thr Pro Gly Asp Gly Ile Leu Glu His Asp 
            260                 265                 270         


Pro Phe Phe Cys Pro Pro Thr Glu Ala Pro Asp Arg Asp Phe Leu Val 
        275                 280                 285             


Asp Ala Leu Val Thr Leu Leu Val Pro Leu Leu Val Ala Leu Leu Leu 
    290                 295                 300                 


Thr Leu Leu Leu Ala Tyr Val Met Cys Cys Arg Arg Glu Gly Arg Leu 
305                 310                 315                 320 


Lys Arg Asp Leu Ala Thr Ser Asp Ile Gln Met Val His His Cys Thr 
                325                 330                 335     


Ile His Gly Asn Thr Glu Glu Leu Arg Gln Met Ala Ala Ser Arg Glu 
            340                 345                 350         


Val Pro Arg Pro Leu Ser Thr Leu Pro Met Phe Asn Val His Thr Gly 
        355                 360                 365             


Glu Arg Leu Pro Pro Arg Val Asp Ser Ala Gln Val Pro Leu Ile Leu 
    370                 375                 380                 


Asp Gln His 
385         


<210>  5
<211>  413
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Gly Gln Pro Gly Asn Gly Ser Ala Phe Leu Leu Ala Pro Asn Arg 
1               5                   10                  15      


Ser His Ala Pro Asp His Asp Val Thr Gln Gln Arg Asp Glu Val Trp 
            20                  25                  30          


Val Val Gly Met Gly Ile Val Met Ser Leu Ile Val Leu Ala Ile Val 
        35                  40                  45              


Phe Gly Asn Val Leu Val Ile Thr Ala Ile Ala Lys Phe Glu Arg Leu 
    50                  55                  60                  


Gln Thr Val Thr Asn Tyr Phe Ile Thr Ser Leu Ala Cys Ala Asp Leu 
65                  70                  75                  80  


Val Met Gly Leu Ala Val Val Pro Phe Gly Ala Ala His Ile Leu Met 
                85                  90                  95      


Lys Met Trp Thr Phe Gly Asn Phe Trp Cys Glu Phe Trp Thr Ser Ile 
            100                 105                 110         


Asp Val Leu Cys Val Thr Ala Ser Ile Glu Thr Leu Cys Val Ile Ala 
        115                 120                 125             


Val Asp Arg Tyr Phe Ala Ile Thr Ser Pro Phe Lys Tyr Gln Ser Leu 
    130                 135                 140                 


Leu Thr Lys Asn Lys Ala Arg Val Ile Ile Leu Met Val Trp Ile Val 
145                 150                 155                 160 


Ser Gly Leu Thr Ser Phe Leu Pro Ile Gln Met His Trp Tyr Arg Ala 
                165                 170                 175     


Thr His Gln Glu Ala Ile Asn Cys Tyr Ala Asn Glu Thr Cys Cys Asp 
            180                 185                 190         


Phe Phe Thr Asn Gln Ala Tyr Ala Ile Ala Ser Ser Ile Val Ser Phe 
        195                 200                 205             


Tyr Val Pro Leu Val Ile Met Val Phe Val Tyr Ser Arg Val Phe Gln 
    210                 215                 220                 


Glu Ala Lys Arg Gln Leu Gln Lys Ile Asp Lys Ser Glu Gly Arg Phe 
225                 230                 235                 240 


His Val Gln Asn Leu Ser Gln Val Glu Gln Asp Gly Arg Thr Gly His 
                245                 250                 255     


Gly Leu Arg Arg Ser Ser Lys Phe Cys Leu Lys Glu His Lys Ala Leu 
            260                 265                 270         


Lys Thr Leu Gly Ile Ile Met Gly Thr Phe Thr Leu Cys Trp Leu Pro 
        275                 280                 285             


Phe Phe Ile Val Asn Ile Val His Val Ile Gln Asp Asn Leu Ile Arg 
    290                 295                 300                 


Lys Glu Val Tyr Ile Leu Leu Asn Trp Ile Gly Tyr Val Asn Ser Gly 
305                 310                 315                 320 


Phe Asn Pro Leu Ile Tyr Cys Arg Ser Pro Asp Phe Arg Ile Ala Phe 
                325                 330                 335     


Gln Glu Leu Leu Cys Leu Arg Arg Ser Ser Leu Lys Ala Tyr Gly Asn 
            340                 345                 350         


Gly Tyr Ser Ser Asn Gly Asn Thr Gly Glu Gln Ser Gly Tyr His Val 
        355                 360                 365             


Glu Gln Glu Lys Glu Asn Lys Leu Leu Cys Glu Asp Leu Pro Gly Thr 
    370                 375                 380                 


Glu Asp Phe Val Gly His Gln Gly Thr Val Pro Ser Asp Asn Ile Asp 
385                 390                 395                 400 


Ser Gln Gly Arg Asn Cys Ser Thr Asn Asp Ser Leu Leu 
                405                 410             


<210>  6
<211>  408
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Pro Trp Pro His Glu Asn Ser Ser Leu Ala Pro Trp Pro Asp 
1               5                   10                  15      


Leu Pro Thr Leu Ala Pro Asn Thr Ala Asn Thr Ser Gly Leu Pro Gly 
            20                  25                  30          


Val Pro Trp Glu Ala Ala Leu Ala Gly Ala Leu Leu Ala Leu Ala Val 
        35                  40                  45              


Leu Ala Thr Val Gly Gly Asn Leu Leu Val Ile Val Ala Ile Ala Trp 
    50                  55                  60                  


Thr Pro Arg Leu Gln Thr Met Thr Asn Val Phe Val Thr Ser Leu Ala 
65                  70                  75                  80  


Ala Ala Asp Leu Val Met Gly Leu Leu Val Val Pro Pro Ala Ala Thr 
                85                  90                  95      


Leu Ala Leu Thr Gly His Trp Pro Leu Gly Ala Thr Gly Cys Glu Leu 
            100                 105                 110         


Trp Thr Ser Val Asp Val Leu Cys Val Thr Ala Ser Ile Glu Thr Leu 
        115                 120                 125             


Cys Ala Leu Ala Val Asp Arg Tyr Leu Ala Val Thr Asn Pro Leu Arg 
    130                 135                 140                 


Tyr Gly Ala Leu Val Thr Lys Arg Cys Ala Arg Thr Ala Val Val Leu 
145                 150                 155                 160 


Val Trp Val Val Ser Ala Ala Val Ser Phe Ala Pro Ile Met Ser Gln 
                165                 170                 175     


Trp Trp Arg Val Gly Ala Asp Ala Glu Ala Gln Arg Cys His Ser Asn 
            180                 185                 190         


Pro Arg Cys Cys Ala Phe Ala Ser Asn Met Pro Tyr Val Leu Leu Ser 
        195                 200                 205             


Ser Ser Val Ser Phe Tyr Leu Pro Leu Leu Val Met Leu Phe Val Tyr 
    210                 215                 220                 


Ala Arg Val Phe Val Val Ala Thr Arg Gln Leu Arg Leu Leu Arg Gly 
225                 230                 235                 240 


Glu Leu Gly Arg Phe Pro Pro Glu Glu Ser Pro Pro Ala Pro Ser Arg 
                245                 250                 255     


Ser Leu Ala Pro Ala Pro Val Gly Thr Cys Ala Pro Pro Glu Gly Val 
            260                 265                 270         


Pro Ala Cys Gly Arg Arg Pro Ala Arg Leu Leu Pro Leu Arg Glu His 
        275                 280                 285             


Arg Ala Leu Cys Thr Leu Gly Leu Ile Met Gly Thr Phe Thr Leu Cys 
    290                 295                 300                 


Trp Leu Pro Phe Phe Leu Ala Asn Val Leu Arg Ala Leu Gly Gly Pro 
305                 310                 315                 320 


Ser Leu Val Pro Gly Pro Ala Phe Leu Ala Leu Asn Trp Leu Gly Tyr 
                325                 330                 335     


Ala Asn Ser Ala Phe Asn Pro Leu Ile Tyr Cys Arg Ser Pro Asp Phe 
            340                 345                 350         


Arg Ser Ala Phe Arg Arg Leu Leu Cys Arg Cys Gly Arg Arg Leu Pro 
        355                 360                 365             


Pro Glu Pro Cys Ala Ala Ala Arg Pro Ala Leu Phe Pro Ser Gly Val 
    370                 375                 380                 


Pro Ala Ala Arg Ser Ser Pro Ala Gln Pro Arg Leu Cys Gln Arg Leu 
385                 390                 395                 400 


Asp Gly Ala Ser Trp Gly Val Ser 
                405             


<210>  7
<211>  1880
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Pro Tyr Ser Val Gly Phe Arg Glu Ala Asp Ala Ala Thr Ser Phe 
1               5                   10                  15      


Leu Arg Ala Ala Arg Ser Gly Asn Leu Asp Lys Ala Leu Asp His Leu 
            20                  25                  30          


Arg Asn Gly Val Asp Ile Asn Thr Cys Asn Gln Asn Gly Leu Asn Gly 
        35                  40                  45              


Leu His Leu Ala Ser Lys Glu Gly His Val Lys Met Val Val Glu Leu 
    50                  55                  60                  


Leu His Lys Glu Ile Ile Leu Glu Thr Thr Thr Lys Lys Gly Asn Thr 
65                  70                  75                  80  


Ala Leu His Ile Ala Ala Leu Ala Gly Gln Asp Glu Val Val Arg Glu 
                85                  90                  95      


Leu Val Asn Tyr Gly Ala Asn Val Asn Ala Gln Ser Gln Lys Gly Phe 
            100                 105                 110         


Thr Pro Leu Tyr Met Ala Ala Gln Glu Asn His Leu Glu Val Val Lys 
        115                 120                 125             


Phe Leu Leu Glu Asn Gly Ala Asn Gln Asn Val Ala Thr Glu Asp Gly 
    130                 135                 140                 


Phe Thr Pro Leu Ala Val Ala Leu Gln Gln Gly His Glu Asn Val Val 
145                 150                 155                 160 


Ala His Leu Ile Asn Tyr Gly Thr Lys Gly Lys Val Arg Leu Pro Ala 
                165                 170                 175     


Leu His Ile Ala Ala Arg Asn Asp Asp Thr Arg Thr Ala Ala Val Leu 
            180                 185                 190         


Leu Gln Asn Asp Pro Asn Pro Asp Val Leu Ser Lys Thr Gly Phe Thr 
        195                 200                 205             


Pro Leu His Ile Ala Ala His Tyr Glu Asn Leu Asn Val Ala Gln Leu 
    210                 215                 220                 


Leu Leu Asn Arg Gly Ala Ser Val Asn Phe Thr Pro Gln Asn Gly Ile 
225                 230                 235                 240 


Thr Pro Leu His Ile Ala Ser Arg Arg Gly Asn Val Ile Met Val Arg 
                245                 250                 255     


Leu Leu Leu Asp Arg Gly Ala Gln Ile Glu Thr Lys Thr Lys Asp Glu 
            260                 265                 270         


Leu Thr Pro Leu His Cys Ala Ala Arg Asn Gly His Val Arg Ile Ser 
        275                 280                 285             


Glu Ile Leu Leu Asp His Gly Ala Pro Ile Gln Ala Lys Thr Lys Asn 
    290                 295                 300                 


Gly Leu Ser Pro Ile His Met Ala Ala Gln Gly Asp His Leu Asp Cys 
305                 310                 315                 320 


Val Arg Leu Leu Leu Gln Tyr Asp Ala Glu Ile Asp Asp Ile Thr Leu 
                325                 330                 335     


Asp His Leu Thr Pro Leu His Val Ala Ala His Cys Gly His His Arg 
            340                 345                 350         


Val Ala Lys Val Leu Leu Asp Lys Gly Ala Lys Pro Asn Ser Arg Ala 
        355                 360                 365             


Leu Asn Gly Phe Thr Pro Leu His Ile Ala Cys Lys Lys Asn His Val 
    370                 375                 380                 


Arg Val Met Glu Leu Leu Leu Lys Thr Gly Ala Ser Ile Asp Ala Val 
385                 390                 395                 400 


Thr Glu Ser Gly Leu Thr Pro Leu His Val Ala Ser Phe Met Gly His 
                405                 410                 415     


Leu Pro Ile Val Lys Asn Leu Leu Gln Arg Gly Ala Ser Pro Asn Val 
            420                 425                 430         


Ser Asn Val Lys Val Glu Thr Pro Leu His Met Ala Ala Arg Ala Gly 
        435                 440                 445             


His Thr Glu Val Ala Lys Tyr Leu Leu Gln Asn Lys Ala Lys Val Asn 
    450                 455                 460                 


Ala Lys Ala Lys Asp Asp Gln Thr Pro Leu His Cys Ala Ala Arg Ile 
465                 470                 475                 480 


Gly His Thr Asn Met Val Lys Leu Leu Leu Glu Asn Asn Ala Asn Pro 
                485                 490                 495     


Asn Leu Ala Thr Thr Ala Gly His Thr Pro Leu His Ile Ala Ala Arg 
            500                 505                 510         


Glu Gly His Val Glu Thr Val Leu Ala Leu Leu Glu Lys Glu Ala Ser 
        515                 520                 525             


Gln Ala Cys Met Thr Lys Lys Gly Phe Thr Pro Leu His Val Ala Ala 
    530                 535                 540                 


Lys Tyr Gly Lys Val Arg Val Ala Glu Leu Leu Leu Glu Arg Asp Ala 
545                 550                 555                 560 


His Pro Asn Ala Ala Gly Lys Asn Gly Leu Thr Pro Leu His Val Ala 
                565                 570                 575     


Val His His Asn Asn Leu Asp Ile Val Lys Leu Leu Leu Pro Arg Gly 
            580                 585                 590         


Gly Ser Pro His Ser Pro Ala Trp Asn Gly Tyr Thr Pro Leu His Ile 
        595                 600                 605             


Ala Ala Lys Gln Asn Gln Val Glu Val Ala Arg Ser Leu Leu Gln Tyr 
    610                 615                 620                 


Gly Gly Ser Ala Asn Ala Glu Ser Val Gln Gly Val Thr Pro Leu His 
625                 630                 635                 640 


Leu Ala Ala Gln Glu Gly His Ala Glu Met Val Ala Leu Leu Leu Ser 
                645                 650                 655     


Lys Gln Ala Asn Gly Asn Leu Gly Asn Lys Ser Gly Leu Thr Pro Leu 
            660                 665                 670         


His Leu Val Ala Gln Glu Gly His Val Pro Val Ala Asp Val Leu Ile 
        675                 680                 685             


Lys His Gly Val Met Val Asp Ala Thr Thr Arg Met Gly Tyr Thr Pro 
    690                 695                 700                 


Leu His Val Ala Ser His Tyr Gly Asn Ile Lys Leu Val Lys Phe Leu 
705                 710                 715                 720 


Leu Gln His Gln Ala Asp Val Asn Ala Lys Thr Lys Leu Gly Tyr Ser 
                725                 730                 735     


Pro Leu His Gln Ala Ala Gln Gln Gly His Thr Asp Ile Val Thr Leu 
            740                 745                 750         


Leu Leu Lys Asn Gly Ala Ser Pro Asn Glu Val Ser Ser Asp Gly Thr 
        755                 760                 765             


Thr Pro Leu Ala Ile Ala Lys Arg Leu Gly Tyr Ile Ser Val Thr Asp 
    770                 775                 780                 


Val Leu Lys Val Val Thr Asp Glu Thr Ser Phe Val Leu Val Ser Asp 
785                 790                 795                 800 


Lys His Arg Met Ser Phe Pro Glu Thr Val Asp Glu Ile Leu Asp Val 
                805                 810                 815     


Ser Glu Asp Glu Gly Glu Glu Leu Ile Ser Phe Lys Ala Glu Arg Arg 
            820                 825                 830         


Asp Ser Arg Asp Val Asp Glu Glu Lys Glu Leu Leu Asp Phe Val Pro 
        835                 840                 845             


Lys Leu Asp Gln Val Val Glu Ser Pro Ala Ile Pro Arg Ile Pro Cys 
    850                 855                 860                 


Ala Met Pro Glu Thr Val Val Ile Arg Ser Glu Glu Gln Glu Gln Ala 
865                 870                 875                 880 


Ser Lys Glu Tyr Asp Glu Asp Ser Leu Ile Pro Ser Ser Pro Ala Thr 
                885                 890                 895     


Glu Thr Ser Asp Asn Ile Ser Pro Val Ala Ser Pro Val His Thr Gly 
            900                 905                 910         


Phe Leu Val Ser Phe Met Val Asp Ala Arg Gly Gly Ser Met Arg Gly 
        915                 920                 925             


Ser Arg His Asn Gly Leu Arg Val Val Ile Pro Pro Arg Thr Cys Ala 
    930                 935                 940                 


Ala Pro Thr Arg Ile Thr Cys Arg Leu Val Lys Pro Gln Lys Leu Ser 
945                 950                 955                 960 


Thr Pro Pro Pro Leu Ala Glu Glu Glu Gly Leu Ala Ser Arg Ile Ile 
                965                 970                 975     


Ala Leu Gly Pro Thr Gly Ala Gln Phe Leu Ser Pro Val Ile Val Glu 
            980                 985                 990         


Ile Pro His Phe Ala Ser His Gly  Arg Gly Asp Arg Glu  Leu Val Val 
        995                 1000                 1005             


Leu Arg  Ser Glu Asn Gly Ser  Val Trp Lys Glu His  Arg Ser Arg 
    1010                 1015                 1020             


Tyr Gly  Glu Ser Tyr Leu Asp  Gln Ile Leu Asn Gly  Met Asp Glu 
    1025                 1030                 1035             


Glu Leu  Gly Ser Leu Glu Glu  Leu Glu Lys Lys Arg  Val Cys Arg 
    1040                 1045                 1050             


Ile Ile  Thr Thr Asp Phe Pro  Leu Tyr Phe Val Ile  Met Ser Arg 
    1055                 1060                 1065             


Leu Cys  Gln Asp Tyr Asp Thr  Ile Gly Pro Glu Gly  Gly Ser Leu 
    1070                 1075                 1080             


Lys Ser  Lys Leu Val Pro Leu  Val Gln Ala Thr Phe  Pro Glu Asn 
    1085                 1090                 1095             


Ala Val  Thr Lys Arg Val Lys  Leu Ala Leu Gln Ala  Gln Pro Val 
    1100                 1105                 1110             


Pro Asp  Glu Leu Val Thr Lys  Leu Leu Gly Asn Gln  Ala Thr Phe 
    1115                 1120                 1125             


Ser Pro  Ile Val Thr Val Glu  Pro Arg Arg Arg Lys  Phe His Arg 
    1130                 1135                 1140             


Pro Ile  Gly Leu Arg Ile Pro  Leu Pro Pro Ser Trp  Thr Asp Asn 
    1145                 1150                 1155             


Pro Arg  Asp Ser Gly Glu Gly  Asp Thr Thr Ser Leu  Arg Leu Leu 
    1160                 1165                 1170             


Cys Ser  Val Ile Gly Gly Thr  Asp Gln Ala Gln Trp  Glu Asp Ile 
    1175                 1180                 1185             


Thr Gly  Thr Thr Lys Leu Val  Tyr Ala Asn Glu Cys  Ala Asn Phe 
    1190                 1195                 1200             


Thr Thr  Asn Val Ser Ala Arg  Phe Trp Leu Ser Asp  Cys Pro Arg 
    1205                 1210                 1215             


Thr Ala  Glu Ala Val Asn Phe  Ala Thr Leu Leu Tyr  Lys Glu Leu 
    1220                 1225                 1230             


Thr Ala  Val Pro Tyr Met Ala  Lys Phe Val Ile Phe  Ala Lys Met 
    1235                 1240                 1245             


Asn Asp  Pro Arg Glu Gly Arg  Leu Arg Cys Tyr Cys  Met Thr Asp 
    1250                 1255                 1260             


Asp Lys  Val Asp Lys Thr Leu  Glu Gln His Glu Asn  Phe Val Glu 
    1265                 1270                 1275             


Val Ala  Arg Ser Arg Asp Ile  Glu Val Leu Glu Gly  Met Ser Leu 
    1280                 1285                 1290             


Phe Ala  Glu Leu Ser Gly Asn  Leu Val Pro Val Lys  Lys Ala Ala 
    1295                 1300                 1305             


Gln Gln  Arg Ser Phe His Phe  Gln Ser Phe Arg Glu  Asn Arg Leu 
    1310                 1315                 1320             


Ala Met  Pro Val Lys Val Arg  Asp Ser Ser Arg Glu  Pro Gly Gly 
    1325                 1330                 1335             


Ser Leu  Ser Phe Leu Arg Lys  Ala Met Lys Tyr Glu  Asp Thr Gln 
    1340                 1345                 1350             


His Ile  Leu Cys His Leu Asn  Ile Thr Met Pro Pro  Cys Ala Lys 
    1355                 1360                 1365             


Gly Ser  Gly Ala Glu Asp Arg  Arg Arg Thr Pro Thr  Pro Leu Ala 
    1370                 1375                 1380             


Leu Arg  Tyr Ser Ile Leu Ser  Glu Ser Thr Pro Gly  Ser Leu Ser 
    1385                 1390                 1395             


Gly Thr  Glu Gln Ala Glu Met  Lys Met Ala Val Ile  Ser Glu His 
    1400                 1405                 1410             


Leu Gly  Leu Ser Trp Ala Glu  Leu Ala Arg Glu Leu  Gln Phe Ser 
    1415                 1420                 1425             


Val Glu  Asp Ile Asn Arg Ile  Arg Val Glu Asn Pro  Asn Ser Leu 
    1430                 1435                 1440             


Leu Glu  Gln Ser Val Ala Leu  Leu Asn Leu Trp Val  Ile Arg Glu 
    1445                 1450                 1455             


Gly Gln  Asn Ala Asn Met Glu  Asn Leu Tyr Thr Ala  Leu Gln Ser 
    1460                 1465                 1470             


Ile Asp  Arg Gly Glu Ile Val  Asn Met Leu Glu Gly  Ser Gly Arg 
    1475                 1480                 1485             


Gln Ser  Arg Asn Leu Lys Pro  Asp Arg Arg His Thr  Asp Arg Asp 
    1490                 1495                 1500             


Tyr Ser  Leu Ser Pro Ser Gln  Met Asn Gly Tyr Ser  Ser Leu Gln 
    1505                 1510                 1515             


Asp Glu  Leu Leu Ser Pro Ala  Ser Leu Gly Cys Ala  Leu Ser Ser 
    1520                 1525                 1530             


Pro Leu  Arg Ala Asp Gln Tyr  Trp Asn Glu Val Ala  Val Leu Asp 
    1535                 1540                 1545             


Ala Ile  Pro Leu Ala Ala Thr  Glu His Asp Thr Met  Leu Glu Met 
    1550                 1555                 1560             


Ser Asp  Met Gln Val Trp Ser  Ala Gly Leu Thr Pro  Ser Leu Val 
    1565                 1570                 1575             


Thr Ala  Glu Asp Ser Ser Leu  Glu Cys Ser Lys Ala  Glu Asp Ser 
    1580                 1585                 1590             


Asp Ala  Thr Gly His Glu Trp  Lys Leu Glu Gly Ala  Leu Ser Glu 
    1595                 1600                 1605             


Glu Pro  Arg Gly Pro Glu Leu  Gly Ser Leu Glu Leu  Val Glu Asp 
    1610                 1615                 1620             


Asp Thr  Val Asp Ser Asp Ala  Thr Asn Gly Leu Ile  Asp Leu Leu 
    1625                 1630                 1635             


Glu Gln  Glu Glu Gly Gln Arg  Ser Glu Glu Lys Leu  Pro Gly Ser 
    1640                 1645                 1650             


Lys Arg  Gln Asp Asp Ala Thr  Gly Ala Gly Gln Asp  Ser Glu Asn 
    1655                 1660                 1665             


Glu Val  Ser Leu Val Ser Gly  His Gln Arg Gly Gln  Ala Arg Ile 
    1670                 1675                 1680             


Thr His  Ser Pro Thr Val Ser  Gln Val Thr Glu Arg  Ser Gln Asp 
    1685                 1690                 1695             


Arg Leu  Gln Asp Trp Asp Ala  Asp Gly Ser Ile Val  Ser Tyr Leu 
    1700                 1705                 1710             


Gln Asp  Ala Ala Gln Gly Ser  Trp Gln Glu Glu Val  Thr Gln Gly 
    1715                 1720                 1725             


Pro His  Ser Phe Gln Gly Thr  Ser Thr Met Thr Glu  Gly Leu Glu 
    1730                 1735                 1740             


Pro Gly  Gly Ser Gln Glu Tyr  Glu Lys Val Leu Val  Ser Val Ser 
    1745                 1750                 1755             


Glu His  Thr Trp Thr Glu Gln  Pro Glu Ala Glu Ser  Ser Gln Ala 
    1760                 1765                 1770             


Asp Arg  Asp Arg Arg Gln Gln  Gly Gln Glu Glu Gln  Val Gln Glu 
    1775                 1780                 1785             


Ala Lys  Asn Thr Phe Thr Gln  Val Val Gln Gly Asn  Glu Phe Gln 
    1790                 1795                 1800             


Asn Ile  Pro Gly Glu Gln Val  Thr Glu Glu Gln Phe  Thr Asp Glu 
    1805                 1810                 1815             


Gln Gly  Asn Ile Val Thr Lys  Lys Ile Ile Arg Lys  Val Val Arg 
    1820                 1825                 1830             


Gln Ile  Asp Leu Ser Ser Ala  Asp Ala Ala Gln Glu  His Glu Glu 
    1835                 1840                 1845             


Val Glu  Leu Arg Gly Ser Gly  Leu Gln Pro Asp Leu  Ile Glu Gly 
    1850                 1855                 1860             


Arg Lys  Gly Ala Gln Ile Val  Lys Arg Ala Ser Leu  Lys Arg Gly 
    1865                 1870                 1875             


Lys Gln  
    1880 


<210>  8
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Gly Pro Arg Gly Ala Ala Ser Leu Pro Arg Gly Pro Gly Pro Arg 
1               5                   10                  15      


Arg Leu Leu Leu Pro Val Val Leu Pro Leu Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Ala Pro Pro Gly Ser Gly Ala Gly Ala Ser Arg Pro Pro His Leu Val 
        35                  40                  45              


Phe Leu Leu Ala Asp Asp Leu Gly Trp Asn Asp Val Gly Phe His Gly 
    50                  55                  60                  


Ser Arg Ile Arg Thr Pro His Leu Asp Ala Leu Ala Ala Gly Gly Val 
65                  70                  75                  80  


Leu Leu Asp Asn Tyr Tyr Thr Gln Pro Leu Cys Thr Pro Ser Arg Ser 
                85                  90                  95      


Gln Leu Leu Thr Gly Arg Tyr Gln Ile Arg Thr Gly Leu Gln His Gln 
            100                 105                 110         


Ile Ile Trp Pro Cys Gln Pro Ser Cys Val Pro Leu Asp Glu Lys Leu 
        115                 120                 125             


Leu Pro Gln Leu Leu Lys Glu Ala Gly Tyr Thr Thr His Met Val Gly 
    130                 135                 140                 


Lys Trp His Leu Gly Met Tyr Arg Lys Glu Cys Leu Pro Thr Arg Arg 
145                 150                 155                 160 


Gly Phe Asp Thr Tyr Phe Gly Tyr Leu Leu Gly Ser Glu Asp Tyr Tyr 
                165                 170                 175     


Ser His Glu Arg Cys Thr Leu Ile Asp Ala Leu Asn Val Thr Arg Cys 
            180                 185                 190         


Ala Leu Asp Phe Arg Asp Gly Glu Glu Val Ala Thr Gly Tyr Lys Asn 
        195                 200                 205             


Met Tyr Ser Thr Asn Ile Phe Thr Lys Arg Ala Ile Ala Leu Ile Thr 
    210                 215                 220                 


Asn His Pro Pro Glu Lys Pro Leu Phe Leu Tyr Leu Ala Leu Gln Ser 
225                 230                 235                 240 


Val His Glu Pro Leu Gln Val Pro Glu Glu Tyr Leu Lys Pro Tyr Asp 
                245                 250                 255     


Phe Ile Gln Asp Lys Asn Arg His His Tyr Ala Gly Met Val Ser Leu 
            260                 265                 270         


Met Asp Glu Ala Val Gly Asn Val Thr Ala Ala Leu Lys Ser Ser Gly 
        275                 280                 285             


Leu Trp Asn Asn Thr Val Phe Ile Phe Ser Thr Asp Asn Gly Gly Gln 
    290                 295                 300                 


Thr Leu Ala Gly Gly Asn Asn Trp Pro Leu Arg Gly Arg Lys Trp Ser 
305                 310                 315                 320 


Leu Trp Glu Gly Gly Val Arg Gly Val Gly Phe Val Ala Ser Pro Leu 
                325                 330                 335     


Leu Lys Gln Lys Gly Val Lys Asn Arg Glu Leu Ile His Ile Ser Asp 
            340                 345                 350         


Trp Leu Pro Thr Leu Val Lys Leu Ala Arg Gly His Thr Asn Gly Thr 
        355                 360                 365             


Lys Pro Leu Asp Gly Phe Asp Val Trp Lys Thr Ile Ser Glu Gly Ser 
    370                 375                 380                 


Pro Ser Pro Arg Ile Glu Leu Leu His Asn Ile Asp Pro Asn Phe Val 
385                 390                 395                 400 


Asp Ser Ser Pro Cys Pro Arg Asn Ser Met Ala Pro Ala Lys Asp Asp 
                405                 410                 415     


Ser Ser Leu Pro Glu Tyr Ser Ala Phe Asn Thr Ser Val His Ala Ala 
            420                 425                 430         


Ile Arg His Gly Asn Trp Lys Leu Leu Thr Gly Tyr Pro Gly Cys Gly 
        435                 440                 445             


Tyr Trp Phe Pro Pro Pro Ser Gln Tyr Asn Val Ser Glu Ile Pro Ser 
    450                 455                 460                 


Ser Asp Pro Pro Thr Lys Thr Leu Trp Leu Phe Asp Ile Asp Arg Asp 
465                 470                 475                 480 


Pro Glu Glu Arg His Asp Leu Ser Arg Glu Tyr Pro His Ile Val Thr 
                485                 490                 495     


Lys Leu Leu Ser Arg Leu Gln Phe Tyr His Lys His Ser Val Pro Val 
            500                 505                 510         


Tyr Phe Pro Ala Gln Asp Pro Arg Cys Asp Pro Lys Ala Thr Gly Val 
        515                 520                 525             


Trp Gly Pro Trp Met 
    530             


<210>  9
<211>  589
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Leu His Leu His His Ser Cys Leu Cys Phe Arg Ser Trp Leu Pro 
1               5                   10                  15      


Ala Met Leu Ala Val Leu Leu Ser Leu Ala Pro Ser Ala Ser Ser Asp 
            20                  25                  30          


Ile Ser Ala Ser Arg Pro Asn Ile Leu Leu Leu Met Ala Asp Asp Leu 
        35                  40                  45              


Gly Ile Gly Asp Ile Gly Cys Tyr Gly Asn Asn Thr Met Arg Thr Pro 
    50                  55                  60                  


Asn Ile Asp Arg Leu Ala Glu Asp Gly Val Lys Leu Thr Gln His Ile 
65                  70                  75                  80  


Ser Ala Ala Ser Leu Cys Thr Pro Ser Arg Ala Ala Phe Leu Thr Gly 
                85                  90                  95      


Arg Tyr Pro Val Arg Ser Gly Met Val Ser Ser Ile Gly Tyr Arg Val 
            100                 105                 110         


Leu Gln Trp Thr Gly Ala Ser Gly Gly Leu Pro Thr Asn Glu Thr Thr 
        115                 120                 125             


Phe Ala Lys Ile Leu Lys Glu Lys Gly Tyr Ala Thr Gly Leu Ile Gly 
    130                 135                 140                 


Lys Trp His Leu Gly Leu Asn Cys Glu Ser Ala Ser Asp His Cys His 
145                 150                 155                 160 


His Pro Leu His His Gly Phe Asp His Phe Tyr Gly Met Pro Phe Ser 
                165                 170                 175     


Leu Met Gly Asp Cys Ala Arg Trp Glu Leu Ser Glu Lys Arg Val Asn 
            180                 185                 190         


Leu Glu Gln Lys Leu Asn Phe Leu Phe Gln Val Leu Ala Leu Val Ala 
        195                 200                 205             


Leu Thr Leu Val Ala Gly Lys Leu Thr His Leu Ile Pro Val Ser Trp 
    210                 215                 220                 


Met Pro Val Ile Trp Ser Ala Leu Ser Ala Val Leu Leu Leu Ala Ser 
225                 230                 235                 240 


Ser Tyr Phe Val Gly Ala Leu Ile Val His Ala Asp Cys Phe Leu Met 
                245                 250                 255     


Arg Asn His Thr Ile Thr Glu Gln Pro Met Cys Phe Gln Arg Thr Thr 
            260                 265                 270         


Pro Leu Ile Leu Gln Glu Val Ala Ser Phe Leu Lys Arg Asn Lys His 
        275                 280                 285             


Gly Pro Phe Leu Leu Phe Val Ser Phe Leu His Val His Ile Pro Leu 
    290                 295                 300                 


Ile Thr Met Glu Asn Phe Leu Gly Lys Ser Leu His Gly Leu Tyr Gly 
305                 310                 315                 320 


Asp Asn Val Glu Glu Met Asp Trp Met Val Gly Arg Ile Leu Asp Thr 
                325                 330                 335     


Leu Asp Val Glu Gly Leu Ser Asn Ser Thr Leu Ile Tyr Phe Thr Ser 
            340                 345                 350         


Asp His Gly Gly Ser Leu Glu Asn Gln Leu Gly Asn Thr Gln Tyr Gly 
        355                 360                 365             


Gly Trp Asn Gly Ile Tyr Lys Gly Gly Lys Gly Met Gly Gly Trp Glu 
    370                 375                 380                 


Gly Gly Ile Arg Val Pro Gly Ile Phe Arg Trp Pro Gly Val Leu Pro 
385                 390                 395                 400 


Ala Gly Arg Val Ile Gly Glu Pro Thr Ser Leu Met Asp Val Phe Pro 
                405                 410                 415     


Thr Val Val Arg Leu Ala Gly Gly Glu Val Pro Gln Asp Arg Val Ile 
            420                 425                 430         


Asp Gly Gln Asp Leu Leu Pro Leu Leu Leu Gly Thr Ala Gln His Ser 
        435                 440                 445             


Asp His Glu Phe Leu Met His Tyr Cys Glu Arg Phe Leu His Ala Ala 
    450                 455                 460                 


Arg Trp His Gln Arg Asp Arg Gly Thr Met Trp Lys Val His Phe Val 
465                 470                 475                 480 


Thr Pro Val Phe Gln Pro Glu Gly Ala Gly Ala Cys Tyr Gly Arg Lys 
                485                 490                 495     


Val Cys Pro Cys Phe Gly Glu Lys Val Val His His Asp Pro Pro Leu 
            500                 505                 510         


Leu Phe Asp Leu Ser Arg Asp Pro Ser Glu Thr His Ile Leu Thr Pro 
        515                 520                 525             


Ala Ser Glu Pro Val Phe Tyr Gln Val Met Glu Arg Val Gln Gln Ala 
    530                 535                 540                 


Val Trp Glu His Gln Arg Thr Leu Ser Pro Val Pro Leu Gln Leu Asp 
545                 550                 555                 560 


Arg Leu Gly Asn Ile Trp Arg Pro Trp Leu Gln Pro Cys Cys Gly Pro 
                565                 570                 575     


Phe Pro Leu Cys Trp Cys Leu Arg Glu Asp Asp Pro Gln 
            580                 585                 


<210>  10
<211>  1500
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Asp Pro Ser Met Gly Val Asn Ser Val Thr Ile Ser Val Glu Gly 
1               5                   10                  15      


Met Thr Cys Asn Ser Cys Val Trp Thr Ile Glu Gln Gln Ile Gly Lys 
            20                  25                  30          


Val Asn Gly Val His His Ile Lys Val Ser Leu Glu Glu Lys Asn Ala 
        35                  40                  45              


Thr Ile Ile Tyr Asp Pro Lys Leu Gln Thr Pro Lys Thr Leu Gln Glu 
    50                  55                  60                  


Ala Ile Asp Asp Met Gly Phe Asp Ala Val Ile His Asn Pro Asp Pro 
65                  70                  75                  80  


Leu Pro Val Leu Thr Asp Thr Leu Phe Leu Thr Val Thr Ala Ser Leu 
                85                  90                  95      


Thr Leu Pro Trp Asp His Ile Gln Ser Thr Leu Leu Lys Thr Lys Gly 
            100                 105                 110         


Val Thr Asp Ile Lys Ile Tyr Pro Gln Lys Arg Thr Val Ala Val Thr 
        115                 120                 125             


Ile Ile Pro Ser Ile Val Asn Ala Asn Gln Ile Lys Glu Leu Val Pro 
    130                 135                 140                 


Glu Leu Ser Leu Asp Thr Gly Thr Leu Glu Lys Lys Ser Gly Ala Cys 
145                 150                 155                 160 


Glu Asp His Ser Met Ala Gln Ala Gly Glu Val Val Leu Lys Met Lys 
                165                 170                 175     


Val Glu Gly Met Thr Cys His Ser Cys Thr Ser Thr Ile Glu Gly Lys 
            180                 185                 190         


Ile Gly Lys Leu Gln Gly Val Gln Arg Ile Lys Val Ser Leu Asp Asn 
        195                 200                 205             


Gln Glu Ala Thr Ile Val Tyr Gln Pro His Leu Ile Ser Val Glu Glu 
    210                 215                 220                 


Met Lys Lys Gln Ile Glu Ala Met Gly Phe Pro Ala Phe Val Lys Lys 
225                 230                 235                 240 


Gln Pro Lys Tyr Leu Lys Leu Gly Ala Ile Asp Val Glu Arg Leu Lys 
                245                 250                 255     


Asn Thr Pro Val Lys Ser Ser Glu Gly Ser Gln Gln Arg Ser Pro Ser 
            260                 265                 270         


Tyr Thr Asn Asp Ser Thr Ala Thr Phe Ile Ile Asp Gly Met His Cys 
        275                 280                 285             


Lys Ser Cys Val Ser Asn Ile Glu Ser Thr Leu Ser Ala Leu Gln Tyr 
    290                 295                 300                 


Val Ser Ser Ile Val Val Ser Leu Glu Asn Arg Ser Ala Ile Val Lys 
305                 310                 315                 320 


Tyr Asn Ala Ser Ser Val Thr Pro Glu Ser Leu Arg Lys Ala Ile Glu 
                325                 330                 335     


Ala Val Ser Pro Gly Leu Tyr Arg Val Ser Ile Thr Ser Glu Val Glu 
            340                 345                 350         


Ser Thr Ser Asn Ser Pro Ser Ser Ser Ser Leu Gln Lys Ile Pro Leu 
        355                 360                 365             


Asn Val Val Ser Gln Pro Leu Thr Gln Glu Thr Val Ile Asn Ile Asp 
    370                 375                 380                 


Gly Met Thr Cys Asn Ser Cys Val Gln Ser Ile Glu Gly Val Ile Ser 
385                 390                 395                 400 


Lys Lys Pro Gly Val Lys Ser Ile Arg Val Ser Leu Ala Asn Ser Asn 
                405                 410                 415     


Gly Thr Val Glu Tyr Asp Pro Leu Leu Thr Ser Pro Glu Thr Leu Arg 
            420                 425                 430         


Gly Ala Ile Glu Asp Met Gly Phe Asp Ala Thr Leu Ser Asp Thr Asn 
        435                 440                 445             


Glu Pro Leu Val Val Ile Ala Gln Pro Ser Ser Glu Met Pro Leu Leu 
    450                 455                 460                 


Thr Ser Thr Asn Glu Phe Tyr Thr Lys Gly Met Thr Pro Val Gln Asp 
465                 470                 475                 480 


Lys Glu Glu Gly Lys Asn Ser Ser Lys Cys Tyr Ile Gln Val Thr Gly 
                485                 490                 495     


Met Thr Cys Ala Ser Cys Val Ala Asn Ile Glu Arg Asn Leu Arg Arg 
            500                 505                 510         


Glu Glu Gly Ile Tyr Ser Ile Leu Val Ala Leu Met Ala Gly Lys Ala 
        515                 520                 525             


Glu Val Arg Tyr Asn Pro Ala Val Ile Gln Pro Pro Met Ile Ala Glu 
    530                 535                 540                 


Phe Ile Arg Glu Leu Gly Phe Gly Ala Thr Val Ile Glu Asn Ala Asp 
545                 550                 555                 560 


Glu Gly Asp Gly Val Leu Glu Leu Val Val Arg Gly Met Thr Cys Ala 
                565                 570                 575     


Ser Cys Val His Lys Ile Glu Ser Ser Leu Thr Lys His Arg Gly Ile 
            580                 585                 590         


Leu Tyr Cys Ser Val Ala Leu Ala Thr Asn Lys Ala His Ile Lys Tyr 
        595                 600                 605             


Asp Pro Glu Ile Ile Gly Pro Arg Asp Ile Ile His Thr Ile Glu Ser 
    610                 615                 620                 


Leu Gly Phe Glu Ala Ser Leu Val Lys Lys Asp Arg Ser Ala Ser His 
625                 630                 635                 640 


Leu Asp His Lys Arg Glu Ile Arg Gln Trp Arg Arg Ser Phe Leu Val 
                645                 650                 655     


Ser Leu Phe Phe Cys Ile Pro Val Met Gly Leu Met Ile Tyr Met Met 
            660                 665                 670         


Val Met Asp His His Phe Ala Thr Leu His His Asn Gln Asn Met Ser 
        675                 680                 685             


Lys Glu Glu Met Ile Asn Leu His Ser Ser Met Phe Leu Glu Arg Gln 
    690                 695                 700                 


Ile Leu Pro Gly Leu Ser Val Met Asn Leu Leu Ser Phe Leu Leu Cys 
705                 710                 715                 720 


Val Pro Val Gln Phe Phe Gly Gly Trp Tyr Phe Tyr Ile Gln Ala Tyr 
                725                 730                 735     


Lys Ala Leu Lys His Lys Thr Ala Asn Met Asp Val Leu Ile Val Leu 
            740                 745                 750         


Ala Thr Thr Ile Ala Phe Ala Tyr Ser Leu Ile Ile Leu Leu Val Ala 
        755                 760                 765             


Met Tyr Glu Arg Ala Lys Val Asn Pro Ile Thr Phe Phe Asp Thr Pro 
    770                 775                 780                 


Pro Met Leu Phe Val Phe Ile Ala Leu Gly Arg Trp Leu Glu His Ile 
785                 790                 795                 800 


Ala Lys Gly Lys Thr Ser Glu Ala Leu Ala Lys Leu Ile Ser Leu Gln 
                805                 810                 815     


Ala Thr Glu Ala Thr Ile Val Thr Leu Asp Ser Asp Asn Ile Leu Leu 
            820                 825                 830         


Ser Glu Glu Gln Val Asp Val Glu Leu Val Gln Arg Gly Asp Ile Ile 
        835                 840                 845             


Lys Val Val Pro Gly Gly Lys Phe Pro Val Asp Gly Arg Val Ile Glu 
    850                 855                 860                 


Gly His Ser Met Val Asp Glu Ser Leu Ile Thr Gly Glu Ala Met Pro 
865                 870                 875                 880 


Val Ala Lys Lys Pro Gly Ser Thr Val Ile Ala Gly Ser Ile Asn Gln 
                885                 890                 895     


Asn Gly Ser Leu Leu Ile Cys Ala Thr His Val Gly Ala Asp Thr Thr 
            900                 905                 910         


Leu Ser Gln Ile Val Lys Leu Val Glu Glu Ala Gln Thr Ser Lys Ala 
        915                 920                 925             


Pro Ile Gln Gln Phe Ala Asp Lys Leu Ser Gly Tyr Phe Val Pro Phe 
    930                 935                 940                 


Ile Val Phe Val Ser Ile Ala Thr Leu Leu Val Trp Ile Val Ile Gly 
945                 950                 955                 960 


Phe Leu Asn Phe Glu Ile Val Glu Thr Tyr Phe Pro Gly Tyr Asn Arg 
                965                 970                 975     


Ser Ile Ser Arg Thr Glu Thr Ile Ile Arg Phe Ala Phe Gln Ala Ser 
            980                 985                 990         


Ile Thr Val Leu Cys Ile Ala Cys  Pro Cys Ser Leu Gly  Leu Ala Thr 
        995                 1000                 1005             


Pro Thr  Ala Val Met Val Gly  Thr Gly Val Gly Ala  Gln Asn Gly 
    1010                 1015                 1020             


Ile Leu  Ile Lys Gly Gly Glu  Pro Leu Glu Met Ala  His Lys Val 
    1025                 1030                 1035             


Lys Val  Val Val Phe Asp Lys  Thr Gly Thr Ile Thr  His Gly Thr 
    1040                 1045                 1050             


Pro Val  Val Asn Gln Val Lys  Val Leu Thr Glu Ser  Asn Arg Ile 
    1055                 1060                 1065             


Ser His  His Lys Ile Leu Ala  Ile Val Gly Thr Ala  Glu Ser Asn 
    1070                 1075                 1080             


Ser Glu  His Pro Leu Gly Thr  Ala Ile Thr Lys Tyr  Cys Lys Gln 
    1085                 1090                 1095             


Glu Leu  Asp Thr Glu Thr Leu  Gly Thr Cys Ile Asp  Phe Gln Val 
    1100                 1105                 1110             


Val Pro  Gly Cys Gly Ile Ser  Cys Lys Val Thr Asn  Ile Glu Gly 
    1115                 1120                 1125             


Leu Leu  His Lys Asn Asn Trp  Asn Ile Glu Asp Asn  Asn Ile Lys 
    1130                 1135                 1140             


Asn Ala  Ser Leu Val Gln Ile  Asp Ala Ser Asn Glu  Gln Ser Ser 
    1145                 1150                 1155             


Thr Ser  Ser Ser Met Ile Ile  Asp Ala Gln Ile Ser  Asn Ala Leu 
    1160                 1165                 1170             


Asn Ala  Gln Gln Tyr Lys Val  Leu Ile Gly Asn Arg  Glu Trp Met 
    1175                 1180                 1185             


Ile Arg  Asn Gly Leu Val Ile  Asn Asn Asp Val Asn  Asp Phe Met 
    1190                 1195                 1200             


Thr Glu  His Glu Arg Lys Gly  Arg Thr Ala Val Leu  Val Ala Val 
    1205                 1210                 1215             


Asp Asp  Glu Leu Cys Gly Leu  Ile Ala Ile Ala Asp  Thr Val Lys 
    1220                 1225                 1230             


Pro Glu  Ala Glu Leu Ala Ile  His Ile Leu Lys Ser  Met Gly Leu 
    1235                 1240                 1245             


Glu Val  Val Leu Met Thr Gly  Asp Asn Ser Lys Thr  Ala Arg Ser 
    1250                 1255                 1260             


Ile Ala  Ser Gln Val Gly Ile  Thr Lys Val Phe Ala  Glu Val Leu 
    1265                 1270                 1275             


Pro Ser  His Lys Val Ala Lys  Val Lys Gln Leu Gln  Glu Glu Gly 
    1280                 1285                 1290             


Lys Arg  Val Ala Met Val Gly  Asp Gly Ile Asn Asp  Ser Pro Ala 
    1295                 1300                 1305             


Leu Ala  Met Ala Asn Val Gly  Ile Ala Ile Gly Thr  Gly Thr Asp 
    1310                 1315                 1320             


Val Ala  Ile Glu Ala Ala Asp  Val Val Leu Ile Arg  Asn Asp Leu 
    1325                 1330                 1335             


Leu Asp  Val Val Ala Ser Ile  Asp Leu Ser Arg Lys  Thr Val Lys 
    1340                 1345                 1350             


Arg Ile  Arg Ile Asn Phe Val  Phe Ala Leu Ile Tyr  Asn Leu Val 
    1355                 1360                 1365             


Gly Ile  Pro Ile Ala Ala Gly  Val Phe Met Pro Ile  Gly Leu Val 
    1370                 1375                 1380             


Leu Gln  Pro Trp Met Gly Ser  Ala Ala Met Ala Ala  Ser Ser Val 
    1385                 1390                 1395             


Ser Val  Val Leu Ser Ser Leu  Phe Leu Lys Leu Tyr  Arg Lys Pro 
    1400                 1405                 1410             


Thr Tyr  Glu Ser Tyr Glu Leu  Pro Ala Arg Ser Gln  Ile Gly Gln 
    1415                 1420                 1425             


Lys Ser  Pro Ser Glu Ile Ser  Val His Val Gly Ile  Asp Asp Thr 
    1430                 1435                 1440             


Ser Arg  Asn Ser Pro Lys Leu  Gly Leu Leu Asp Arg  Ile Val Asn 
    1445                 1450                 1455             


Tyr Ser  Arg Ala Ser Ile Asn  Ser Leu Leu Ser Asp  Lys Arg Ser 
    1460                 1465                 1470             


Leu Asn  Ser Val Val Thr Ser  Glu Pro Asp Lys His  Ser Leu Leu 
    1475                 1480                 1485             


Val Gly  Asp Phe Arg Glu Asp  Asp Asp Thr Ala Leu  
    1490                 1495                 1500 


<210>  11
<211>  1465
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Pro Glu Gln Glu Arg Gln Ile Thr Ala Arg Glu Gly Ala Ser Arg 
1               5                   10                  15      


Lys Ile Leu Ser Lys Leu Ser Leu Pro Thr Arg Ala Trp Glu Pro Ala 
            20                  25                  30          


Met Lys Lys Ser Phe Ala Phe Asp Asn Val Gly Tyr Glu Gly Gly Leu 
        35                  40                  45              


Asp Gly Leu Gly Pro Ser Ser Gln Val Ala Thr Ser Thr Val Arg Ile 
    50                  55                  60                  


Leu Gly Met Thr Cys Gln Ser Cys Val Lys Ser Ile Glu Asp Arg Ile 
65                  70                  75                  80  


Ser Asn Leu Lys Gly Ile Ile Ser Met Lys Val Ser Leu Glu Gln Gly 
                85                  90                  95      


Ser Ala Thr Val Lys Tyr Val Pro Ser Val Val Cys Leu Gln Gln Val 
            100                 105                 110         


Cys His Gln Ile Gly Asp Met Gly Phe Glu Ala Ser Ile Ala Glu Gly 
        115                 120                 125             


Lys Ala Ala Ser Trp Pro Ser Arg Ser Leu Pro Ala Gln Glu Ala Val 
    130                 135                 140                 


Val Lys Leu Arg Val Glu Gly Met Thr Cys Gln Ser Cys Val Ser Ser 
145                 150                 155                 160 


Ile Glu Gly Lys Val Arg Lys Leu Gln Gly Val Val Arg Val Lys Val 
                165                 170                 175     


Ser Leu Ser Asn Gln Glu Ala Val Ile Thr Tyr Gln Pro Tyr Leu Ile 
            180                 185                 190         


Gln Pro Glu Asp Leu Arg Asp His Val Asn Asp Met Gly Phe Glu Ala 
        195                 200                 205             


Ala Ile Lys Ser Lys Val Ala Pro Leu Ser Leu Gly Pro Ile Asp Ile 
    210                 215                 220                 


Glu Arg Leu Gln Ser Thr Asn Pro Lys Arg Pro Leu Ser Ser Ala Asn 
225                 230                 235                 240 


Gln Asn Phe Asn Asn Ser Glu Thr Leu Gly His Gln Gly Ser His Val 
                245                 250                 255     


Val Thr Leu Gln Leu Arg Ile Asp Gly Met His Cys Lys Ser Cys Val 
            260                 265                 270         


Leu Asn Ile Glu Glu Asn Ile Gly Gln Leu Leu Gly Val Gln Ser Ile 
        275                 280                 285             


Gln Val Ser Leu Glu Asn Lys Thr Ala Gln Val Lys Tyr Asp Pro Ser 
    290                 295                 300                 


Cys Thr Ser Pro Val Ala Leu Gln Arg Ala Ile Glu Ala Leu Pro Pro 
305                 310                 315                 320 


Gly Asn Phe Lys Val Ser Leu Pro Asp Gly Ala Glu Gly Ser Gly Thr 
                325                 330                 335     


Asp His Arg Ser Ser Ser Ser His Ser Pro Gly Ser Pro Pro Arg Asn 
            340                 345                 350         


Gln Val Gln Gly Thr Cys Ser Thr Thr Leu Ile Ala Ile Ala Gly Met 
        355                 360                 365             


Thr Cys Ala Ser Cys Val His Ser Ile Glu Gly Met Ile Ser Gln Leu 
    370                 375                 380                 


Glu Gly Val Gln Gln Ile Ser Val Ser Leu Ala Glu Gly Thr Ala Thr 
385                 390                 395                 400 


Val Leu Tyr Asn Pro Ser Val Ile Ser Pro Glu Glu Leu Arg Ala Ala 
                405                 410                 415     


Ile Glu Asp Met Gly Phe Glu Ala Ser Val Val Ser Glu Ser Cys Ser 
            420                 425                 430         


Thr Asn Pro Leu Gly Asn His Ser Ala Gly Asn Ser Met Val Gln Thr 
        435                 440                 445             


Thr Asp Gly Thr Pro Thr Ser Val Gln Glu Val Ala Pro His Thr Gly 
    450                 455                 460                 


Arg Leu Pro Ala Asn His Ala Pro Asp Ile Leu Ala Lys Ser Pro Gln 
465                 470                 475                 480 


Ser Thr Arg Ala Val Ala Pro Gln Lys Cys Phe Leu Gln Ile Lys Gly 
                485                 490                 495     


Met Thr Cys Ala Ser Cys Val Ser Asn Ile Glu Arg Asn Leu Gln Lys 
            500                 505                 510         


Glu Ala Gly Val Leu Ser Val Leu Val Ala Leu Met Ala Gly Lys Ala 
        515                 520                 525             


Glu Ile Lys Tyr Asp Pro Glu Val Ile Gln Pro Leu Glu Ile Ala Gln 
    530                 535                 540                 


Phe Ile Gln Asp Leu Gly Phe Glu Ala Ala Val Met Glu Asp Tyr Ala 
545                 550                 555                 560 


Gly Ser Asp Gly Asn Ile Glu Leu Thr Ile Thr Gly Met Thr Cys Ala 
                565                 570                 575     


Ser Cys Val His Asn Ile Glu Ser Lys Leu Thr Arg Thr Asn Gly Ile 
            580                 585                 590         


Thr Tyr Ala Ser Val Ala Leu Ala Thr Ser Lys Ala Leu Val Lys Phe 
        595                 600                 605             


Asp Pro Glu Ile Ile Gly Pro Arg Asp Ile Ile Lys Ile Ile Glu Glu 
    610                 615                 620                 


Ile Gly Phe His Ala Ser Leu Ala Gln Arg Asn Pro Asn Ala His His 
625                 630                 635                 640 


Leu Asp His Lys Met Glu Ile Lys Gln Trp Lys Lys Ser Phe Leu Cys 
                645                 650                 655     


Ser Leu Val Phe Gly Ile Pro Val Met Ala Leu Met Ile Tyr Met Leu 
            660                 665                 670         


Ile Pro Ser Asn Glu Pro His Gln Ser Met Val Leu Asp His Asn Ile 
        675                 680                 685             


Ile Pro Gly Leu Ser Ile Leu Asn Leu Ile Phe Phe Ile Leu Cys Thr 
    690                 695                 700                 


Phe Val Gln Leu Leu Gly Gly Trp Tyr Phe Tyr Val Gln Ala Tyr Lys 
705                 710                 715                 720 


Ser Leu Arg His Arg Ser Ala Asn Met Asp Val Leu Ile Val Leu Ala 
                725                 730                 735     


Thr Ser Ile Ala Tyr Val Tyr Ser Leu Val Ile Leu Val Val Ala Val 
            740                 745                 750         


Ala Glu Lys Ala Glu Arg Ser Pro Val Thr Phe Phe Asp Thr Pro Pro 
        755                 760                 765             


Met Leu Phe Val Phe Ile Ala Leu Gly Arg Trp Leu Glu His Leu Ala 
    770                 775                 780                 


Lys Ser Lys Thr Ser Glu Ala Leu Ala Lys Leu Met Ser Leu Gln Ala 
785                 790                 795                 800 


Thr Glu Ala Thr Val Val Thr Leu Gly Glu Asp Asn Leu Ile Ile Arg 
                805                 810                 815     


Glu Glu Gln Val Pro Met Glu Leu Val Gln Arg Gly Asp Ile Val Lys 
            820                 825                 830         


Val Val Pro Gly Gly Lys Phe Pro Val Asp Gly Lys Val Leu Glu Gly 
        835                 840                 845             


Asn Thr Met Ala Asp Glu Ser Leu Ile Thr Gly Glu Ala Met Pro Val 
    850                 855                 860                 


Thr Lys Lys Pro Gly Ser Thr Val Ile Ala Gly Ser Ile Asn Ala His 
865                 870                 875                 880 


Gly Ser Val Leu Ile Lys Ala Thr His Val Gly Asn Asp Thr Thr Leu 
                885                 890                 895     


Ala Gln Ile Val Lys Leu Val Glu Glu Ala Gln Met Ser Lys Ala Pro 
            900                 905                 910         


Ile Gln Gln Leu Ala Asp Arg Phe Ser Gly Tyr Phe Val Pro Phe Ile 
        915                 920                 925             


Ile Ile Met Ser Thr Leu Thr Leu Val Val Trp Ile Val Ile Gly Phe 
    930                 935                 940                 


Ile Asp Phe Gly Val Val Gln Arg Tyr Phe Pro Asn Pro Asn Lys His 
945                 950                 955                 960 


Ile Ser Gln Thr Glu Val Ile Ile Arg Phe Ala Phe Gln Thr Ser Ile 
                965                 970                 975     


Thr Val Leu Cys Ile Ala Cys Pro Cys Ser Leu Gly Leu Ala Thr Pro 
            980                 985                 990         


Thr Ala Val Met Val Gly Thr Gly  Val Ala Ala Gln Asn  Gly Ile Leu 
        995                 1000                 1005             


Ile Lys  Gly Gly Lys Pro Leu  Glu Met Ala His Lys  Ile Lys Thr 
    1010                 1015                 1020             


Val Met  Phe Asp Lys Thr Gly  Thr Ile Thr His Gly  Val Pro Arg 
    1025                 1030                 1035             


Val Met  Arg Val Leu Leu Leu  Gly Asp Val Ala Thr  Leu Pro Leu 
    1040                 1045                 1050             


Arg Lys  Val Leu Ala Val Val  Gly Thr Ala Glu Ala  Ser Ser Glu 
    1055                 1060                 1065             


His Pro  Leu Gly Val Ala Val  Thr Lys Tyr Cys Lys  Glu Glu Leu 
    1070                 1075                 1080             


Gly Thr  Glu Thr Leu Gly Tyr  Cys Thr Asp Phe Gln  Ala Val Pro 
    1085                 1090                 1095             


Gly Cys  Gly Ile Gly Cys Lys  Val Ser Asn Val Glu  Gly Ile Leu 
    1100                 1105                 1110             


Ala His  Ser Glu Arg Pro Leu  Ser Ala Pro Ala Ser  His Leu Asn 
    1115                 1120                 1125             


Glu Ala  Gly Ser Leu Pro Ala  Glu Lys Asp Ala Val  Pro Gln Thr 
    1130                 1135                 1140             


Phe Ser  Val Leu Ile Gly Asn  Arg Glu Trp Leu Arg  Arg Asn Gly 
    1145                 1150                 1155             


Leu Thr  Ile Ser Ser Asp Val  Ser Asp Ala Met Thr  Asp His Glu 
    1160                 1165                 1170             


Met Lys  Gly Gln Thr Ala Ile  Leu Val Ala Ile Asp  Gly Val Leu 
    1175                 1180                 1185             


Cys Gly  Met Ile Ala Ile Ala  Asp Ala Val Lys Gln  Glu Ala Ala 
    1190                 1195                 1200             


Leu Ala  Val His Thr Leu Gln  Ser Met Gly Val Asp  Val Val Leu 
    1205                 1210                 1215             


Ile Thr  Gly Asp Asn Arg Lys  Thr Ala Arg Ala Ile  Ala Thr Gln 
    1220                 1225                 1230             


Val Gly  Ile Asn Lys Val Phe  Ala Glu Val Leu Pro  Ser His Lys 
    1235                 1240                 1245             


Val Ala  Lys Val Gln Glu Leu  Gln Asn Lys Gly Lys  Lys Val Ala 
    1250                 1255                 1260             


Met Val  Gly Asp Gly Val Asn  Asp Ser Pro Ala Leu  Ala Gln Ala 
    1265                 1270                 1275             


Asp Met  Gly Val Ala Ile Gly  Thr Gly Thr Asp Val  Ala Ile Glu 
    1280                 1285                 1290             


Ala Ala  Asp Val Val Leu Ile  Arg Asn Asp Leu Leu  Asp Val Val 
    1295                 1300                 1305             


Ala Ser  Ile His Leu Ser Lys  Arg Thr Val Arg Arg  Ile Arg Ile 
    1310                 1315                 1320             


Asn Leu  Val Leu Ala Leu Ile  Tyr Asn Leu Val Gly  Ile Pro Ile 
    1325                 1330                 1335             


Ala Ala  Gly Val Phe Met Pro  Ile Gly Ile Val Leu  Gln Pro Trp 
    1340                 1345                 1350             


Met Gly  Ser Ala Ala Met Ala  Ala Ser Ser Val Ser  Val Val Leu 
    1355                 1360                 1365             


Ser Ser  Leu Gln Leu Lys Cys  Tyr Lys Lys Pro Asp  Leu Glu Arg 
    1370                 1375                 1380             


Tyr Glu  Ala Gln Ala His Gly  His Met Lys Pro Leu  Thr Ala Ser 
    1385                 1390                 1395             


Gln Val  Ser Val His Ile Gly  Met Asp Asp Arg Trp  Arg Asp Ser 
    1400                 1405                 1410             


Pro Arg  Ala Thr Pro Trp Asp  Gln Val Ser Tyr Val  Ser Gln Val 
    1415                 1420                 1425             


Ser Leu  Ser Ser Leu Thr Ser  Asp Lys Pro Ser Arg  His Ser Ala 
    1430                 1435                 1440             


Ala Ala  Asp Asp Asp Gly Asp  Lys Trp Ser Leu Leu  Leu Asn Gly 
    1445                 1450                 1455             


Arg Asp  Glu Glu Gln Tyr Ile  
    1460                 1465 


<210>  12
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Leu Met Ala Ser Thr Thr Ser Ala Val Pro Gly His Pro Ser Leu 
1               5                   10                  15      


Pro Ser Leu Pro Ser Asn Ser Ser Gln Glu Arg Pro Leu Asp Thr Arg 
            20                  25                  30          


Asp Pro Leu Leu Ala Arg Ala Glu Leu Ala Leu Leu Ser Ile Val Phe 
        35                  40                  45              


Val Ala Val Ala Leu Ser Asn Gly Leu Val Leu Ala Ala Leu Ala Arg 
    50                  55                  60                  


Arg Gly Arg Arg Gly His Trp Ala Pro Ile His Val Phe Ile Gly His 
65                  70                  75                  80  


Leu Cys Leu Ala Asp Leu Ala Val Ala Leu Phe Gln Val Leu Pro Gln 
                85                  90                  95      


Leu Ala Trp Lys Ala Thr Asp Arg Phe Arg Gly Pro Asp Ala Leu Cys 
            100                 105                 110         


Arg Ala Val Lys Tyr Leu Gln Met Val Gly Met Tyr Ala Ser Ser Tyr 
        115                 120                 125             


Met Ile Leu Ala Met Thr Leu Asp Arg His Arg Ala Ile Cys Arg Pro 
    130                 135                 140                 


Met Leu Ala Tyr Arg His Gly Ser Gly Ala His Trp Asn Arg Pro Val 
145                 150                 155                 160 


Leu Val Ala Trp Ala Phe Ser Leu Leu Leu Ser Leu Pro Gln Leu Phe 
                165                 170                 175     


Ile Phe Ala Gln Arg Asn Val Glu Gly Gly Ser Gly Val Thr Asp Cys 
            180                 185                 190         


Trp Ala Cys Phe Ala Glu Pro Trp Gly Arg Arg Thr Tyr Val Thr Trp 
        195                 200                 205             


Ile Ala Leu Met Val Phe Val Ala Pro Thr Leu Gly Ile Ala Ala Cys 
    210                 215                 220                 


Gln Val Leu Ile Phe Arg Glu Ile His Ala Ser Leu Val Pro Gly Pro 
225                 230                 235                 240 


Ser Glu Arg Pro Gly Gly Arg Arg Arg Gly Arg Arg Thr Gly Ser Pro 
                245                 250                 255     


Gly Glu Gly Ala His Val Ser Ala Ala Val Ala Lys Thr Val Arg Met 
            260                 265                 270         


Thr Leu Val Ile Val Val Val Tyr Val Leu Cys Trp Ala Pro Phe Phe 
        275                 280                 285             


Leu Val Gln Leu Trp Ala Ala Trp Asp Pro Glu Ala Pro Leu Glu Gly 
    290                 295                 300                 


Ala Pro Phe Val Leu Leu Met Leu Leu Ala Ser Leu Asn Ser Cys Thr 
305                 310                 315                 320 


Asn Pro Trp Ile Tyr Ala Ser Phe Ser Ser Ser Val Ser Ser Glu Leu 
                325                 330                 335     


Arg Ser Leu Leu Cys Cys Ala Arg Gly Arg Thr Pro Pro Ser Leu Gly 
            340                 345                 350         


Pro Gln Asp Glu Ser Cys Thr Thr Ala Ser Ser Ser Leu Ala Lys Asp 
        355                 360                 365             


Thr Ser Ser 
    370     


<210>  13
<211>  602
<212>  PRT
<213>  Homo sapiens

<400>  13

Met His Ser Lys Val Thr Ile Ile Cys Ile Arg Phe Leu Phe Trp Phe 
1               5                   10                  15      


Leu Leu Leu Cys Met Leu Ile Gly Lys Ser His Thr Glu Asp Asp Ile 
            20                  25                  30          


Ile Ile Ala Thr Lys Asn Gly Lys Val Arg Gly Met Asn Leu Thr Val 
        35                  40                  45              


Phe Gly Gly Thr Val Thr Ala Phe Leu Gly Ile Pro Tyr Ala Gln Pro 
    50                  55                  60                  


Pro Leu Gly Arg Leu Arg Phe Lys Lys Pro Gln Ser Leu Thr Lys Trp 
65                  70                  75                  80  


Ser Asp Ile Trp Asn Ala Thr Lys Tyr Ala Asn Ser Cys Cys Gln Asn 
                85                  90                  95      


Ile Asp Gln Ser Phe Pro Gly Phe His Gly Ser Glu Met Trp Asn Pro 
            100                 105                 110         


Asn Thr Asp Leu Ser Glu Asp Cys Leu Tyr Leu Asn Val Trp Ile Pro 
        115                 120                 125             


Ala Pro Lys Pro Lys Asn Ala Thr Val Leu Ile Trp Ile Tyr Gly Gly 
    130                 135                 140                 


Gly Phe Gln Thr Gly Thr Ser Ser Leu His Val Tyr Asp Gly Lys Phe 
145                 150                 155                 160 


Leu Ala Arg Val Glu Arg Val Ile Val Val Ser Met Asn Tyr Arg Val 
                165                 170                 175     


Gly Ala Leu Gly Phe Leu Ala Leu Pro Gly Asn Pro Glu Ala Pro Gly 
            180                 185                 190         


Asn Met Gly Leu Phe Asp Gln Gln Leu Ala Leu Gln Trp Val Gln Lys 
        195                 200                 205             


Asn Ile Ala Ala Phe Gly Gly Asn Pro Lys Ser Val Thr Leu Phe Gly 
    210                 215                 220                 


Glu Ser Ala Gly Ala Ala Ser Val Ser Leu His Leu Leu Ser Pro Gly 
225                 230                 235                 240 


Ser His Ser Leu Phe Thr Arg Ala Ile Leu Gln Ser Gly Ser Phe Asn 
                245                 250                 255     


Ala Pro Trp Ala Val Thr Ser Leu Tyr Glu Ala Arg Asn Arg Thr Leu 
            260                 265                 270         


Asn Leu Ala Lys Leu Thr Gly Cys Ser Arg Glu Asn Glu Thr Glu Ile 
        275                 280                 285             


Ile Lys Cys Leu Arg Asn Lys Asp Pro Gln Glu Ile Leu Leu Asn Glu 
    290                 295                 300                 


Ala Phe Val Val Pro Tyr Gly Thr Pro Leu Ser Val Asn Phe Gly Pro 
305                 310                 315                 320 


Thr Val Asp Gly Asp Phe Leu Thr Asp Met Pro Asp Ile Leu Leu Glu 
                325                 330                 335     


Leu Gly Gln Phe Lys Lys Thr Gln Ile Leu Val Gly Val Asn Lys Asp 
            340                 345                 350         


Glu Gly Thr Ala Phe Leu Val Tyr Gly Ala Pro Gly Phe Ser Lys Asp 
        355                 360                 365             


Asn Asn Ser Ile Ile Thr Arg Lys Glu Phe Gln Glu Gly Leu Lys Ile 
    370                 375                 380                 


Phe Phe Pro Gly Val Ser Glu Phe Gly Lys Glu Ser Ile Leu Phe His 
385                 390                 395                 400 


Tyr Thr Asp Trp Val Asp Asp Gln Arg Pro Glu Asn Tyr Arg Glu Ala 
                405                 410                 415     


Leu Gly Asp Val Val Gly Asp Tyr Asn Phe Ile Cys Pro Ala Leu Glu 
            420                 425                 430         


Phe Thr Lys Lys Phe Ser Glu Trp Gly Asn Asn Ala Phe Phe Tyr Tyr 
        435                 440                 445             


Phe Glu His Arg Ser Ser Lys Leu Pro Trp Pro Glu Trp Met Gly Val 
    450                 455                 460                 


Met His Gly Tyr Glu Ile Glu Phe Val Phe Gly Leu Pro Leu Glu Arg 
465                 470                 475                 480 


Arg Asp Asn Tyr Thr Lys Ala Glu Glu Ile Leu Ser Arg Ser Ile Val 
                485                 490                 495     


Lys Arg Trp Ala Asn Phe Ala Lys Tyr Gly Asn Pro Asn Glu Thr Gln 
            500                 505                 510         


Asn Asn Ser Thr Ser Trp Pro Val Phe Lys Ser Thr Glu Gln Lys Tyr 
        515                 520                 525             


Leu Thr Leu Asn Thr Glu Ser Thr Arg Ile Met Thr Lys Leu Arg Ala 
    530                 535                 540                 


Gln Gln Cys Arg Phe Trp Thr Ser Phe Phe Pro Lys Val Leu Glu Met 
545                 550                 555                 560 


Thr Gly Asn Ile Asp Glu Ala Glu Trp Glu Trp Lys Ala Gly Phe His 
                565                 570                 575     


Arg Trp Asn Asn Tyr Met Met Asp Trp Lys Asn Gln Phe Asn Asp Tyr 
            580                 585                 590         


Thr Ser Lys Lys Glu Ser Cys Val Gly Leu 
        595                 600         


<210>  14
<211>  591
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Lys Asn Ser Arg Thr Trp Ala Trp Arg Ala Pro Val Glu Leu Phe 
1               5                   10                  15      


Leu Leu Cys Ala Ala Leu Gly Cys Leu Ser Leu Pro Gly Ser Arg Gly 
            20                  25                  30          


Glu Arg Pro His Ser Phe Gly Ser Asn Ala Val Asn Lys Ser Phe Ala 
        35                  40                  45              


Lys Ser Arg Gln Met Arg Ser Val Asp Val Thr Leu Met Pro Ile Asp 
    50                  55                  60                  


Cys Glu Leu Ser Ser Trp Ser Ser Trp Thr Thr Cys Asp Pro Cys Gln 
65                  70                  75                  80  


Lys Lys Arg Tyr Arg Tyr Ala Tyr Leu Leu Gln Pro Ser Gln Phe His 
                85                  90                  95      


Gly Glu Pro Cys Asn Phe Ser Asp Lys Glu Val Glu Asp Cys Val Thr 
            100                 105                 110         


Asn Arg Pro Cys Arg Ser Gln Val Arg Cys Glu Gly Phe Val Cys Ala 
        115                 120                 125             


Gln Thr Gly Arg Cys Val Asn Arg Arg Leu Leu Cys Asn Gly Asp Asn 
    130                 135                 140                 


Asp Cys Gly Asp Gln Ser Asp Glu Ala Asn Cys Arg Arg Ile Tyr Lys 
145                 150                 155                 160 


Lys Cys Gln His Glu Met Asp Gln Tyr Trp Gly Ile Gly Ser Leu Ala 
                165                 170                 175     


Ser Gly Ile Asn Leu Phe Thr Asn Ser Phe Glu Gly Pro Val Leu Asp 
            180                 185                 190         


His Arg Tyr Tyr Ala Gly Gly Cys Ser Pro His Tyr Ile Leu Asn Thr 
        195                 200                 205             


Arg Phe Arg Lys Pro Tyr Asn Val Glu Ser Tyr Thr Pro Gln Thr Gln 
    210                 215                 220                 


Gly Lys Tyr Glu Phe Ile Leu Lys Glu Tyr Glu Ser Tyr Ser Asp Phe 
225                 230                 235                 240 


Glu Arg Asn Val Thr Glu Lys Met Ala Ser Lys Ser Gly Phe Ser Phe 
                245                 250                 255     


Gly Phe Lys Ile Pro Gly Ile Phe Glu Leu Gly Ile Ser Ser Gln Ser 
            260                 265                 270         


Asp Arg Gly Lys His Tyr Ile Arg Arg Thr Lys Arg Phe Ser His Thr 
        275                 280                 285             


Lys Ser Val Phe Leu His Ala Arg Ser Asp Leu Glu Val Ala His Tyr 
    290                 295                 300                 


Lys Leu Lys Pro Arg Ser Leu Met Leu His Tyr Glu Phe Leu Gln Arg 
305                 310                 315                 320 


Val Lys Arg Leu Pro Leu Glu Tyr Ser Tyr Gly Glu Tyr Arg Asp Leu 
                325                 330                 335     


Phe Arg Asp Phe Gly Thr His Tyr Ile Thr Glu Ala Val Leu Gly Gly 
            340                 345                 350         


Ile Tyr Glu Tyr Thr Leu Val Met Asn Lys Glu Ala Met Glu Arg Gly 
        355                 360                 365             


Asp Tyr Thr Leu Asn Asn Val His Ala Cys Ala Lys Asn Asp Phe Lys 
    370                 375                 380                 


Ile Gly Gly Ala Ile Glu Glu Val Tyr Val Ser Leu Gly Val Ser Val 
385                 390                 395                 400 


Gly Lys Cys Arg Gly Ile Leu Asn Glu Ile Lys Asp Arg Asn Lys Arg 
                405                 410                 415     


Asp Thr Met Val Glu Asp Leu Val Val Leu Val Arg Gly Gly Ala Ser 
            420                 425                 430         


Glu His Ile Thr Thr Leu Ala Tyr Gln Glu Leu Pro Thr Ala Asp Leu 
        435                 440                 445             


Met Gln Glu Trp Gly Asp Ala Val Gln Tyr Asn Pro Ala Ile Ile Lys 
    450                 455                 460                 


Val Lys Val Glu Pro Leu Tyr Glu Leu Val Thr Ala Thr Asp Phe Ala 
465                 470                 475                 480 


Tyr Ser Ser Thr Val Arg Gln Asn Met Lys Gln Ala Leu Glu Glu Phe 
                485                 490                 495     


Gln Lys Glu Val Ser Ser Cys His Cys Ala Pro Cys Gln Gly Asn Gly 
            500                 505                 510         


Val Pro Val Leu Lys Gly Ser Arg Cys Asp Cys Ile Cys Pro Val Gly 
        515                 520                 525             


Ser Gln Gly Leu Ala Cys Glu Val Ser Tyr Arg Lys Asn Thr Pro Ile 
    530                 535                 540                 


Asp Gly Lys Trp Asn Cys Trp Ser Asn Trp Ser Ser Cys Ser Gly Arg 
545                 550                 555                 560 


Arg Lys Thr Arg Gln Arg Gln Cys Asn Asn Pro Pro Pro Gln Asn Gly 
                565                 570                 575     


Gly Ser Pro Cys Ser Gly Pro Ala Ser Glu Thr Leu Asp Cys Ser 
            580                 585                 590     


<210>  15
<211>  1873
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Glu Pro Ser Ser Pro Gln Asp Glu Gly Leu Arg Lys Lys Gln Pro 
1               5                   10                  15      


Lys Lys Pro Val Pro Glu Ile Leu Pro Arg Pro Pro Arg Ala Leu Phe 
            20                  25                  30          


Cys Leu Thr Leu Glu Asn Pro Leu Arg Lys Ala Cys Ile Ser Ile Val 
        35                  40                  45              


Glu Trp Lys Pro Phe Glu Thr Ile Ile Leu Leu Thr Ile Phe Ala Asn 
    50                  55                  60                  


Cys Val Ala Leu Ala Val Tyr Leu Pro Met Pro Glu Asp Asp Asn Asn 
65                  70                  75                  80  


Ser Leu Asn Leu Gly Leu Glu Lys Leu Glu Tyr Phe Phe Leu Ile Val 
                85                  90                  95      


Phe Ser Ile Glu Ala Ala Met Lys Ile Ile Ala Tyr Gly Phe Leu Phe 
            100                 105                 110         


His Gln Asp Ala Tyr Leu Arg Ser Gly Trp Asn Val Leu Asp Phe Thr 
        115                 120                 125             


Ile Val Phe Leu Gly Val Phe Thr Val Ile Leu Glu Gln Val Asn Val 
    130                 135                 140                 


Ile Gln Ser His Thr Ala Pro Met Ser Ser Lys Gly Ala Gly Leu Asp 
145                 150                 155                 160 


Val Lys Ala Leu Arg Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val 
                165                 170                 175     


Ser Gly Val Pro Ser Leu Gln Val Val Leu Asn Ser Ile Phe Lys Ala 
            180                 185                 190         


Met Leu Pro Leu Phe His Ile Ala Leu Leu Val Leu Phe Met Val Ile 
        195                 200                 205             


Ile Tyr Ala Ile Ile Gly Leu Glu Leu Phe Lys Gly Lys Met His Lys 
    210                 215                 220                 


Thr Cys Tyr Phe Ile Gly Thr Asp Ile Val Ala Thr Val Glu Asn Glu 
225                 230                 235                 240 


Glu Pro Ser Pro Cys Ala Arg Thr Gly Ser Gly Arg Arg Cys Thr Ile 
                245                 250                 255     


Asn Gly Ser Glu Cys Arg Gly Gly Trp Pro Gly Pro Asn His Gly Ile 
            260                 265                 270         


Thr His Phe Asp Asn Phe Gly Phe Ser Met Leu Thr Val Tyr Gln Cys 
        275                 280                 285             


Ile Thr Met Glu Gly Trp Thr Asp Val Leu Tyr Trp Val Asn Asp Ala 
    290                 295                 300                 


Ile Gly Asn Glu Trp Pro Trp Ile Tyr Phe Val Thr Leu Ile Leu Leu 
305                 310                 315                 320 


Gly Ser Phe Phe Ile Leu Asn Leu Val Leu Gly Val Leu Ser Gly Glu 
                325                 330                 335     


Phe Thr Lys Glu Arg Glu Lys Ala Lys Ser Arg Gly Thr Phe Gln Lys 
            340                 345                 350         


Leu Arg Glu Lys Gln Gln Leu Asp Glu Asp Leu Arg Gly Tyr Met Ser 
        355                 360                 365             


Trp Ile Thr Gln Gly Glu Val Met Asp Val Glu Asp Phe Arg Glu Gly 
    370                 375                 380                 


Lys Leu Ser Leu Asp Glu Gly Gly Ser Asp Thr Glu Ser Leu Tyr Glu 
385                 390                 395                 400 


Ile Ala Gly Leu Asn Lys Ile Ile Gln Phe Ile Arg His Trp Arg Gln 
                405                 410                 415     


Trp Asn Arg Ile Phe Arg Trp Lys Cys His Asp Ile Val Lys Ser Lys 
            420                 425                 430         


Val Phe Tyr Trp Leu Val Ile Leu Ile Val Ala Leu Asn Thr Leu Ser 
        435                 440                 445             


Ile Ala Ser Glu His His Asn Gln Pro Leu Trp Leu Thr Arg Leu Gln 
    450                 455                 460                 


Asp Ile Ala Asn Arg Val Leu Leu Ser Leu Phe Thr Thr Glu Met Leu 
465                 470                 475                 480 


Met Lys Met Tyr Gly Leu Gly Leu Arg Gln Tyr Phe Met Ser Ile Phe 
                485                 490                 495     


Asn Arg Phe Asp Cys Phe Val Val Cys Ser Gly Ile Leu Glu Ile Leu 
            500                 505                 510         


Leu Val Glu Ser Gly Ala Met Thr Pro Leu Gly Ile Ser Val Leu Arg 
        515                 520                 525             


Cys Ile Arg Leu Leu Arg Ile Phe Lys Ile Thr Lys Tyr Trp Thr Ser 
    530                 535                 540                 


Leu Ser Asn Leu Val Ala Ser Leu Leu Asn Ser Ile Arg Ser Ile Ala 
545                 550                 555                 560 


Ser Leu Leu Leu Leu Leu Phe Leu Phe Ile Val Ile Phe Ala Leu Leu 
                565                 570                 575     


Gly Met Gln Leu Phe Gly Gly Arg Tyr Asp Phe Glu Asp Thr Glu Val 
            580                 585                 590         


Arg Arg Ser Asn Phe Asp Asn Phe Pro Gln Ala Leu Ile Ser Val Phe 
        595                 600                 605             


Gln Val Leu Thr Gly Glu Asp Trp Thr Ser Met Met Tyr Asn Gly Ile 
    610                 615                 620                 


Met Ala Tyr Gly Gly Pro Ser Tyr Pro Gly Met Leu Val Cys Ile Tyr 
625                 630                 635                 640 


Phe Ile Ile Leu Phe Val Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe 
                645                 650                 655     


Leu Ala Ile Ala Val Asp Asn Leu Ala Glu Ala Glu Ser Leu Thr Ser 
            660                 665                 670         


Ala Gln Lys Ala Lys Ala Glu Glu Lys Lys Arg Arg Lys Met Ser Lys 
        675                 680                 685             


Gly Leu Pro Asp Lys Ser Glu Glu Glu Lys Ser Thr Met Ala Lys Lys 
    690                 695                 700                 


Leu Glu Gln Lys Pro Lys Gly Glu Gly Ile Pro Thr Thr Ala Lys Leu 
705                 710                 715                 720 


Lys Ile Asp Glu Phe Glu Ser Asn Val Asn Glu Val Lys Asp Pro Tyr 
                725                 730                 735     


Pro Ser Ala Asp Phe Pro Gly Asp Asp Glu Glu Asp Glu Pro Glu Ile 
            740                 745                 750         


Pro Leu Ser Pro Arg Pro Arg Pro Leu Ala Glu Leu Gln Leu Lys Glu 
        755                 760                 765             


Lys Ala Val Pro Ile Pro Glu Ala Ser Ser Phe Phe Ile Phe Ser Pro 
    770                 775                 780                 


Thr Asn Lys Ile Arg Val Leu Cys His Arg Ile Val Asn Ala Thr Trp 
785                 790                 795                 800 


Phe Thr Asn Phe Ile Leu Leu Phe Ile Leu Leu Ser Ser Ala Ala Leu 
                805                 810                 815     


Ala Ala Glu Asp Pro Ile Arg Ala Asp Ser Met Arg Asn Gln Ile Leu 
            820                 825                 830         


Lys His Phe Asp Ile Gly Phe Thr Ser Val Phe Thr Val Glu Ile Val 
        835                 840                 845             


Leu Lys Met Thr Thr Tyr Gly Ala Phe Leu His Lys Gly Ser Phe Cys 
    850                 855                 860                 


Arg Asn Tyr Phe Asn Met Leu Asp Leu Leu Val Val Ala Val Ser Leu 
865                 870                 875                 880 


Ile Ser Met Gly Leu Glu Ser Ser Ala Ile Ser Val Val Lys Ile Leu 
                885                 890                 895     


Arg Val Leu Arg Val Leu Arg Pro Leu Arg Ala Ile Asn Arg Ala Lys 
            900                 905                 910         


Gly Leu Lys His Val Val Gln Cys Met Phe Val Ala Ile Ser Thr Ile 
        915                 920                 925             


Gly Asn Ile Val Leu Val Thr Thr Leu Leu Gln Phe Met Phe Ala Cys 
    930                 935                 940                 


Ile Gly Val Gln Leu Phe Lys Gly Lys Phe Phe Arg Cys Thr Asp Leu 
945                 950                 955                 960 


Ser Lys Met Thr Glu Glu Glu Cys Arg Gly Tyr Tyr Tyr Val Tyr Lys 
                965                 970                 975     


Asp Gly Asp Pro Met Gln Ile Glu Leu Arg His Arg Glu Trp Val His 
            980                 985                 990         


Ser Asp Phe His Phe Asp Asn Val  Leu Ser Ala Met Met  Ser Leu Phe 
        995                 1000                 1005             


Thr Val  Ser Thr Phe Glu Gly  Trp Pro Gln Leu Leu  Tyr Lys Ala 
    1010                 1015                 1020             


Ile Asp  Ser Asn Ala Glu Asp  Val Gly Pro Ile Tyr  Asn Asn Arg 
    1025                 1030                 1035             


Val Glu  Met Ala Ile Phe Phe  Ile Ile Tyr Ile Ile  Leu Ile Ala 
    1040                 1045                 1050             


Phe Phe  Met Met Asn Ile Phe  Val Gly Phe Val Ile  Val Thr Phe 
    1055                 1060                 1065             


Gln Glu  Gln Gly Glu Thr Glu  Tyr Lys Asn Cys Glu  Leu Asp Lys 
    1070                 1075                 1080             


Asn Gln  Arg Gln Cys Val Gln  Tyr Ala Leu Lys Ala  Arg Pro Leu 
    1085                 1090                 1095             


Arg Cys  Tyr Ile Pro Lys Asn  Pro Tyr Gln Tyr Gln  Val Trp Tyr 
    1100                 1105                 1110             


Ile Val  Thr Ser Ser Tyr Phe  Glu Tyr Leu Met Phe  Ala Leu Ile 
    1115                 1120                 1125             


Met Leu  Asn Thr Ile Cys Leu  Gly Met Gln His Tyr  Asn Gln Ser 
    1130                 1135                 1140             


Glu Gln  Met Asn His Ile Ser  Asp Ile Leu Asn Val  Ala Phe Thr 
    1145                 1150                 1155             


Ile Ile  Phe Thr Leu Glu Met  Ile Leu Lys Leu Met  Ala Phe Lys 
    1160                 1165                 1170             


Ala Arg  Gly Tyr Phe Gly Asp  Pro Trp Asn Val Phe  Asp Phe Leu 
    1175                 1180                 1185             


Ile Val  Ile Gly Ser Ile Ile  Asp Val Ile Leu Ser  Glu Ile Asp 
    1190                 1195                 1200             


Thr Phe  Leu Ala Ser Ser Gly  Gly Leu Tyr Cys Leu  Gly Gly Gly 
    1205                 1210                 1215             


Cys Gly  Asn Val Asp Pro Asp  Glu Ser Ala Arg Ile  Ser Ser Ala 
    1220                 1225                 1230             


Phe Phe  Arg Leu Phe Arg Val  Met Arg Leu Ile Lys  Leu Leu Ser 
    1235                 1240                 1245             


Arg Ala  Glu Gly Val Arg Thr  Leu Leu Trp Thr Phe  Ile Lys Ser 
    1250                 1255                 1260             


Phe Gln  Ala Leu Pro Tyr Val  Ala Leu Leu Ile Val  Met Leu Phe 
    1265                 1270                 1275             


Phe Ile  Tyr Ala Val Ile Gly  Met Gln Met Phe Gly  Lys Ile Ala 
    1280                 1285                 1290             


Leu Val  Asp Gly Thr Gln Ile  Asn Arg Asn Asn Asn  Phe Gln Thr 
    1295                 1300                 1305             


Phe Pro  Gln Ala Val Leu Leu  Leu Phe Arg Cys Ala  Thr Gly Glu 
    1310                 1315                 1320             


Ala Trp  Gln Glu Ile Leu Leu  Ala Cys Ser Tyr Gly  Lys Leu Cys 
    1325                 1330                 1335             


Asp Pro  Glu Ser Asp Tyr Ala  Pro Gly Glu Glu Tyr  Thr Cys Gly 
    1340                 1345                 1350             


Thr Asn  Phe Ala Tyr Tyr Tyr  Phe Ile Ser Phe Tyr  Met Leu Cys 
    1355                 1360                 1365             


Ala Phe  Leu Val Ile Asn Leu  Phe Val Ala Val Ile  Met Asp Asn 
    1370                 1375                 1380             


Phe Asp  Tyr Leu Thr Arg Asp  Trp Ser Ile Leu Gly  Pro His His 
    1385                 1390                 1395             


Leu Asp  Glu Phe Lys Ala Ile  Trp Ala Glu Tyr Asp  Pro Glu Ala 
    1400                 1405                 1410             


Lys Gly  Arg Ile Lys His Leu  Asp Val Val Thr Leu  Leu Arg Arg 
    1415                 1420                 1425             


Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Phe Cys Pro  His Arg Val 
    1430                 1435                 1440             


Ala Cys  Lys Arg Leu Val Gly  Met Asn Met Pro Leu  Asn Ser Asp 
    1445                 1450                 1455             


Gly Thr  Val Thr Phe Asn Ala  Thr Leu Phe Ala Leu  Val Arg Thr 
    1460                 1465                 1470             


Ala Leu  Lys Ile Lys Thr Glu  Gly Asn Phe Glu Gln  Ala Asn Glu 
    1475                 1480                 1485             


Glu Leu  Arg Ala Ile Ile Lys  Lys Ile Trp Lys Arg  Thr Ser Met 
    1490                 1495                 1500             


Lys Leu  Leu Asp Gln Val Ile  Pro Pro Ile Gly Asp  Asp Glu Val 
    1505                 1510                 1515             


Thr Val  Gly Lys Phe Tyr Ala  Thr Phe Leu Ile Gln  Glu His Phe 
    1520                 1525                 1530             


Arg Lys  Phe Met Lys Arg Gln  Glu Glu Tyr Tyr Gly  Tyr Arg Pro 
    1535                 1540                 1545             


Lys Lys  Asp Ile Val Gln Ile  Gln Ala Gly Leu Arg  Thr Ile Glu 
    1550                 1555                 1560             


Glu Glu  Ala Ala Pro Glu Ile  Cys Arg Thr Val Ser  Gly Asp Leu 
    1565                 1570                 1575             


Ala Ala  Glu Glu Glu Leu Glu  Arg Ala Met Val Glu  Ala Ala Met 
    1580                 1585                 1590             


Glu Glu  Gly Ile Phe Arg Arg  Thr Gly Gly Leu Phe  Gly Gln Val 
    1595                 1600                 1605             


Asp Asn  Phe Leu Glu Arg Thr  Asn Ser Leu Pro Pro  Val Met Ala 
    1610                 1615                 1620             


Asn Gln  Arg Pro Leu Gln Phe  Ala Glu Ile Glu Met  Glu Glu Met 
    1625                 1630                 1635             


Glu Ser  Pro Val Phe Leu Glu  Asp Phe Pro Gln Asp  Pro Arg Thr 
    1640                 1645                 1650             


Asn Pro  Leu Ala Arg Ala Asn  Thr Asn Asn Ala Asn  Ala Asn Val 
    1655                 1660                 1665             


Ala Tyr  Gly Asn Ser Asn His  Ser Asn Ser His Val  Phe Ser Ser 
    1670                 1675                 1680             


Val His  Tyr Glu Arg Glu Phe  Pro Glu Glu Thr Glu  Thr Pro Ala 
    1685                 1690                 1695             


Thr Arg  Gly Arg Ala Leu Gly  Gln Pro Cys Arg Val  Leu Gly Pro 
    1700                 1705                 1710             


His Ser  Lys Pro Cys Val Glu  Met Leu Lys Gly Leu  Leu Thr Gln 
    1715                 1720                 1725             


Arg Ala  Met Pro Arg Gly Gln  Ala Pro Pro Ala Pro  Cys Gln Cys 
    1730                 1735                 1740             


Pro Arg  Val Glu Ser Ser Met  Pro Glu Asp Arg Lys  Ser Ser Thr 
    1745                 1750                 1755             


Pro Gly  Ser Leu His Glu Glu  Thr Pro His Ser Arg  Ser Thr Arg 
    1760                 1765                 1770             


Glu Asn  Thr Ser Arg Cys Ser  Ala Pro Ala Thr Ala  Leu Leu Ile 
    1775                 1780                 1785             


Gln Lys  Ala Leu Val Arg Gly  Gly Leu Gly Thr Leu  Ala Ala Asp 
    1790                 1795                 1800             


Ala Asn  Phe Ile Met Ala Thr  Gly Gln Ala Leu Ala  Asp Ala Cys 
    1805                 1810                 1815             


Gln Met  Glu Pro Glu Glu Val  Glu Ile Met Ala Thr  Glu Leu Leu 
    1820                 1825                 1830             


Lys Gly  Arg Glu Ala Pro Glu  Gly Met Ala Ser Ser  Leu Gly Cys 
    1835                 1840                 1845             


Leu Asn  Leu Gly Ser Ser Leu  Gly Ser Leu Asp Gln  His Gln Gly 
    1850                 1855                 1860             


Ser Gln  Glu Thr Leu Ile Pro  Pro Arg Leu 
    1865                 1870             


<210>  16
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr Asn Asn Thr Ala 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu 
225                 230                 235                 240 


Ser His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro 
                245                 250                 255     


Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser Ser Asp Ile Cys 
            260                 265                 270         


Arg Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn Leu Lys Gly Ile 
        275                 280                 285             


Pro Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe Ala Ser Pro Val 
    290                 295                 300                 


Glu Asn Pro Asp Asn Tyr Cys Phe Cys Thr Glu Lys Ile Ile Ser Lys 
305                 310                 315                 320 


Asn Cys Thr Ser Tyr Gly Val Leu Asp Ile Ser Lys Cys Lys Glu Gly 
                325                 330                 335     


Arg Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr Ala Ser Pro Asp 
            340                 345                 350         


Val Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu Glu Glu His Arg 
        355                 360                 365             


Thr Tyr Leu Asp Ile Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ala 
    370                 375                 380                 


Lys Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser Glu Lys Ile Gln 
385                 390                 395                 400 


Val Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro Ile Leu Trp Leu 
                405                 410                 415     


Asn Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Asn Met Phe Arg Ser 
            420                 425                 430         


Gln Val Thr Gly Lys Ile Asn Leu Leu Gly Leu Ile Glu Met Ile Leu 
        435                 440                 445             


Leu Ser Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys 
    450                 455                 460                 


Ala Cys Arg Ser Lys Thr Ile Lys 
465                 470         


<210>  17
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg Arg Asn 
            180         


<210>  18
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     


Gly Leu Leu Lys Leu 
            260     


<210>  19
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Glu Pro Trp Pro Leu Leu Leu Leu Phe Ser Leu Cys Ser Ala Gly 
1               5                   10                  15      


Leu Val Leu Gly Ser Glu His Glu Thr Arg Leu Val Ala Lys Leu Phe 
            20                  25                  30          


Lys Asp Tyr Ser Ser Val Val Arg Pro Val Glu Asp His Arg Gln Val 
        35                  40                  45              


Val Glu Val Thr Val Gly Leu Gln Leu Ile Gln Leu Ile Asn Val Asp 
    50                  55                  60                  


Glu Val Asn Gln Ile Val Thr Thr Asn Val Arg Leu Lys Gln Gln Trp 
65                  70                  75                  80  


Val Asp Tyr Asn Leu Lys Trp Asn Pro Asp Asp Tyr Gly Gly Val Lys 
                85                  90                  95      


Lys Ile His Ile Pro Ser Glu Lys Ile Trp Arg Pro Asp Leu Val Leu 
            100                 105                 110         


Tyr Asn Asn Ala Asp Gly Asp Phe Ala Ile Val Lys Phe Thr Lys Val 
        115                 120                 125             


Leu Leu Gln Tyr Thr Gly His Ile Thr Trp Thr Pro Pro Ala Ile Phe 
    130                 135                 140                 


Lys Ser Tyr Cys Glu Ile Ile Val Thr His Phe Pro Phe Asp Glu Gln 
145                 150                 155                 160 


Asn Cys Ser Met Lys Leu Gly Thr Trp Thr Tyr Asp Gly Ser Val Val 
                165                 170                 175     


Ala Ile Asn Pro Glu Ser Asp Gln Pro Asp Leu Ser Asn Phe Met Glu 
            180                 185                 190         


Ser Gly Glu Trp Val Ile Lys Glu Ser Arg Gly Trp Lys His Ser Val 
        195                 200                 205             


Thr Tyr Ser Cys Cys Pro Asp Thr Pro Tyr Leu Asp Ile Thr Tyr His 
    210                 215                 220                 


Phe Val Met Gln Arg Leu Pro Leu Tyr Phe Ile Val Asn Val Ile Ile 
225                 230                 235                 240 


Pro Cys Leu Leu Phe Ser Phe Leu Thr Gly Leu Val Phe Tyr Leu Pro 
                245                 250                 255     


Thr Asp Ser Gly Glu Lys Met Thr Leu Ser Ile Ser Val Leu Leu Ser 
            260                 265                 270         


Leu Thr Val Phe Leu Leu Val Ile Val Glu Leu Ile Pro Ser Thr Ser 
        275                 280                 285             


Ser Ala Val Pro Leu Ile Gly Lys Tyr Met Leu Phe Thr Met Val Phe 
    290                 295                 300                 


Val Ile Ala Ser Ile Ile Ile Thr Val Ile Val Ile Asn Thr His His 
305                 310                 315                 320 


Arg Ser Pro Ser Thr His Val Met Pro Asn Trp Val Arg Lys Val Phe 
                325                 330                 335     


Ile Asp Thr Ile Pro Asn Ile Met Phe Phe Ser Thr Met Lys Arg Pro 
            340                 345                 350         


Ser Arg Glu Lys Gln Asp Lys Lys Ile Phe Thr Glu Asp Ile Asp Ile 
        355                 360                 365             


Ser Asp Ile Ser Gly Lys Pro Gly Pro Pro Pro Met Gly Phe His Ser 
    370                 375                 380                 


Pro Leu Ile Lys His Pro Glu Val Lys Ser Ala Ile Glu Gly Ile Lys 
385                 390                 395                 400 


Tyr Ile Ala Glu Thr Met Lys Ser Asp Gln Glu Ser Asn Asn Ala Ala 
                405                 410                 415     


Ala Glu Trp Lys Tyr Val Ala Met Val Met Asp His Ile Leu Leu Gly 
            420                 425                 430         


Val Phe Met Leu Val Cys Ile Ile Gly Thr Leu Ala Val Phe Ala Gly 
        435                 440                 445             


Arg Leu Ile Glu Leu Asn Gln Gln Gly 
    450                 455         


<210>  20
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Arg Ala Pro Leu Gly Val Leu Leu Leu Leu Gly Leu Leu Gly 
1               5                   10                  15      


Arg Gly Val Gly Lys Asn Glu Glu Leu Arg Leu Tyr His His Leu Phe 
            20                  25                  30          


Asn Asn Tyr Asp Pro Gly Ser Arg Pro Val Arg Glu Pro Glu Asp Thr 
        35                  40                  45              


Val Thr Ile Ser Leu Lys Val Thr Leu Thr Asn Leu Ile Ser Leu Asn 
    50                  55                  60                  


Glu Lys Glu Glu Thr Leu Thr Thr Ser Val Trp Ile Gly Ile Asp Trp 
65                  70                  75                  80  


Gln Asp Tyr Arg Leu Asn Tyr Ser Lys Asp Asp Phe Gly Gly Ile Glu 
                85                  90                  95      


Thr Leu Arg Val Pro Ser Glu Leu Val Trp Leu Pro Glu Ile Val Leu 
            100                 105                 110         


Glu Asn Asn Ile Asp Gly Gln Phe Gly Val Ala Tyr Asp Ala Asn Val 
        115                 120                 125             


Leu Val Tyr Glu Gly Gly Ser Val Thr Trp Leu Pro Pro Ala Ile Tyr 
    130                 135                 140                 


Arg Ser Val Cys Ala Val Glu Val Thr Tyr Phe Pro Phe Asp Trp Gln 
145                 150                 155                 160 


Asn Cys Ser Leu Ile Phe Arg Ser Gln Thr Tyr Asn Ala Glu Glu Val 
                165                 170                 175     


Glu Phe Thr Phe Ala Val Asp Asn Asp Gly Lys Thr Ile Asn Lys Ile 
            180                 185                 190         


Asp Ile Asp Thr Glu Ala Tyr Thr Glu Asn Gly Glu Trp Ala Ile Asp 
        195                 200                 205             


Phe Cys Pro Gly Val Ile Arg Arg His His Gly Gly Ala Thr Asp Gly 
    210                 215                 220                 


Pro Gly Glu Thr Asp Val Ile Tyr Ser Leu Ile Ile Arg Arg Lys Pro 
225                 230                 235                 240 


Leu Phe Tyr Val Ile Asn Ile Ile Val Pro Cys Val Leu Ile Ser Gly 
                245                 250                 255     


Leu Val Leu Leu Ala Tyr Phe Leu Pro Ala Gln Ala Gly Gly Gln Lys 
            260                 265                 270         


Cys Thr Val Ser Ile Asn Val Leu Leu Ala Gln Thr Val Phe Leu Phe 
        275                 280                 285             


Leu Ile Ala Gln Lys Ile Pro Glu Thr Ser Leu Ser Val Pro Leu Leu 
    290                 295                 300                 


Gly Arg Phe Leu Ile Phe Val Met Val Val Ala Thr Leu Ile Val Met 
305                 310                 315                 320 


Asn Cys Val Ile Val Leu Asn Val Ser Gln Arg Thr Pro Thr Thr His 
                325                 330                 335     


Ala Met Ser Pro Arg Leu Arg His Val Leu Leu Glu Leu Leu Pro Arg 
            340                 345                 350         


Leu Leu Gly Ser Pro Pro Pro Pro Glu Ala Pro Arg Ala Ala Ser Pro 
        355                 360                 365             


Pro Arg Arg Ala Ser Ser Val Gly Leu Leu Leu Arg Ala Glu Glu Leu 
    370                 375                 380                 


Ile Leu Lys Lys Pro Arg Ser Glu Leu Val Phe Glu Gly Gln Arg His 
385                 390                 395                 400 


Arg Gln Gly Thr Trp Thr Ala Ala Phe Cys Gln Ser Leu Gly Ala Ala 
                405                 410                 415     


Ala Pro Glu Val Arg Cys Cys Val Asp Ala Val Asn Phe Val Ala Glu 
            420                 425                 430         


Ser Thr Arg Asp Gln Glu Ala Thr Gly Glu Glu Val Ser Asp Trp Val 
        435                 440                 445             


Arg Met Gly Asn Ala Leu Asp Asn Ile Cys Phe Trp Ala Ala Leu Val 
    450                 455                 460                 


Leu Phe Ser Val Gly Ser Ser Leu Ile Phe Leu Gly Ala Tyr Phe Asn 
465                 470                 475                 480 


Arg Val Pro Asp Leu Pro Tyr Ala Pro Cys Ile Gln Pro 
                485                 490             


<210>  21
<211>  988
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Glu Gln Ser Arg Ser Gln Gln Arg Gly Gly Glu Gln Ser Trp Trp 
1               5                   10                  15      


Gly Ser Asp Pro Gln Tyr Gln Tyr Met Pro Phe Glu His Cys Thr Ser 
            20                  25                  30          


Tyr Gly Leu Pro Ser Glu Asn Gly Gly Leu Gln His Arg Leu Arg Lys 
        35                  40                  45              


Asp Ala Gly Pro Arg His Asn Val His Pro Thr Gln Ile Tyr Gly His 
    50                  55                  60                  


His Lys Glu Gln Phe Ser Asp Arg Glu Gln Asp Ile Gly Met Pro Lys 
65                  70                  75                  80  


Lys Thr Gly Ser Ser Ser Thr Val Asp Ser Lys Asp Glu Asp His Tyr 
                85                  90                  95      


Ser Lys Cys Gln Asp Cys Ile His Arg Leu Gly Gln Val Val Arg Arg 
            100                 105                 110         


Lys Leu Gly Glu Asp Trp Ile Phe Leu Val Leu Leu Gly Leu Leu Met 
        115                 120                 125             


Ala Leu Val Ser Trp Ser Met Asp Tyr Val Ser Ala Lys Ser Leu Gln 
    130                 135                 140                 


Ala Tyr Lys Trp Ser Tyr Ala Gln Met Gln Pro Ser Leu Pro Leu Gln 
145                 150                 155                 160 


Phe Leu Val Trp Val Thr Phe Pro Leu Val Leu Ile Leu Phe Ser Ala 
                165                 170                 175     


Leu Phe Cys His Leu Ile Ser Pro Gln Ala Val Gly Ser Gly Ile Pro 
            180                 185                 190         


Glu Met Lys Thr Ile Leu Arg Gly Val Val Leu Lys Glu Tyr Leu Thr 
        195                 200                 205             


Met Lys Ala Phe Val Ala Lys Val Val Ala Leu Thr Ala Gly Leu Gly 
    210                 215                 220                 


Ser Gly Ile Pro Val Gly Lys Glu Gly Pro Phe Val His Ile Ala Ser 
225                 230                 235                 240 


Ile Cys Ala Ala Val Leu Ser Lys Phe Met Ser Val Phe Cys Gly Val 
                245                 250                 255     


Tyr Glu Gln Pro Tyr Tyr Tyr Ser Asp Ile Leu Thr Val Gly Cys Ala 
            260                 265                 270         


Val Gly Val Gly Cys Cys Phe Gly Thr Pro Leu Gly Gly Val Leu Phe 
        275                 280                 285             


Ser Ile Glu Val Thr Ser Thr Tyr Phe Ala Val Arg Asn Tyr Trp Arg 
    290                 295                 300                 


Gly Phe Phe Ala Ala Thr Phe Ser Ala Phe Val Phe Arg Val Leu Ala 
305                 310                 315                 320 


Val Trp Asn Lys Asp Ala Val Thr Ile Thr Ala Leu Phe Arg Thr Asn 
                325                 330                 335     


Phe Arg Met Asp Phe Pro Phe Asp Leu Lys Glu Leu Pro Ala Phe Ala 
            340                 345                 350         


Ala Ile Gly Ile Cys Cys Gly Leu Leu Gly Ala Val Phe Val Tyr Leu 
        355                 360                 365             


His Arg Gln Val Met Leu Gly Val Arg Lys His Lys Ala Leu Ser Gln 
    370                 375                 380                 


Phe Leu Ala Lys His Arg Leu Leu Tyr Pro Gly Ile Val Thr Phe Val 
385                 390                 395                 400 


Ile Ala Ser Phe Thr Phe Pro Pro Gly Met Gly Gln Phe Met Ala Gly 
                405                 410                 415     


Glu Leu Met Pro Arg Glu Ala Ile Ser Thr Leu Phe Asp Asn Asn Thr 
            420                 425                 430         


Trp Val Lys His Ala Gly Asp Pro Glu Ser Leu Gly Gln Ser Ala Val 
        435                 440                 445             


Trp Ile His Pro Arg Val Asn Val Val Ile Ile Ile Phe Leu Phe Phe 
    450                 455                 460                 


Val Met Lys Phe Trp Met Ser Ile Val Ala Thr Thr Met Pro Ile Pro 
465                 470                 475                 480 


Cys Gly Gly Phe Met Pro Val Phe Val Leu Gly Ala Ala Phe Gly Arg 
                485                 490                 495     


Leu Val Gly Glu Ile Met Ala Met Leu Phe Pro Asp Gly Ile Leu Phe 
            500                 505                 510         


Asp Asp Ile Ile Tyr Lys Ile Leu Pro Gly Gly Tyr Ala Val Ile Gly 
        515                 520                 525             


Ala Ala Ala Leu Thr Gly Ala Val Ser His Thr Val Ser Thr Ala Val 
    530                 535                 540                 


Ile Cys Phe Glu Leu Thr Gly Gln Ile Ala His Ile Leu Pro Met Met 
545                 550                 555                 560 


Val Ala Val Ile Leu Ala Asn Met Val Ala Gln Ser Leu Gln Pro Ser 
                565                 570                 575     


Leu Tyr Asp Ser Ile Ile Gln Val Lys Lys Leu Pro Tyr Leu Pro Asp 
            580                 585                 590         


Leu Gly Trp Asn Gln Leu Ser Lys Tyr Thr Ile Phe Val Glu Asp Ile 
        595                 600                 605             


Met Val Arg Asp Val Lys Phe Val Ser Ala Ser Tyr Thr Tyr Gly Glu 
    610                 615                 620                 


Leu Arg Thr Leu Leu Gln Thr Thr Thr Val Lys Thr Leu Pro Leu Val 
625                 630                 635                 640 


Asp Ser Lys Asp Ser Met Ile Leu Leu Gly Ser Val Glu Arg Ser Glu 
                645                 650                 655     


Leu Gln Ala Leu Leu Gln Arg His Leu Cys Pro Glu Arg Arg Leu Arg 
            660                 665                 670         


Ala Ala Gln Glu Met Ala Arg Lys Leu Ser Glu Leu Pro Tyr Asp Gly 
        675                 680                 685             


Lys Ala Arg Leu Ala Gly Glu Gly Leu Pro Gly Ala Pro Pro Gly Arg 
    690                 695                 700                 


Pro Glu Ser Phe Ala Phe Val Asp Glu Asp Glu Asp Glu Asp Leu Ser 
705                 710                 715                 720 


Gly Lys Ser Glu Leu Pro Pro Ser Leu Ala Leu His Pro Ser Thr Thr 
                725                 730                 735     


Ala Pro Leu Ser Pro Glu Glu Pro Asn Gly Pro Leu Pro Gly His Lys 
            740                 745                 750         


Gln Gln Pro Glu Ala Pro Glu Pro Ala Gly Gln Arg Pro Ser Ile Phe 
        755                 760                 765             


Gln Ser Leu Leu His Cys Leu Leu Gly Arg Ala Arg Pro Thr Lys Lys 
    770                 775                 780                 


Lys Thr Thr Gln Asp Ser Thr Asp Leu Val Asp Asn Met Ser Pro Glu 
785                 790                 795                 800 


Glu Ile Glu Ala Trp Glu Gln Glu Gln Leu Ser Gln Pro Val Cys Phe 
                805                 810                 815     


Asp Ser Cys Cys Ile Asp Gln Ser Pro Phe Gln Leu Val Glu Gln Thr 
            820                 825                 830         


Thr Leu His Lys Thr His Thr Leu Phe Ser Leu Leu Gly Leu His Leu 
        835                 840                 845             


Ala Tyr Val Thr Ser Met Gly Lys Leu Arg Gly Val Leu Ala Leu Glu 
    850                 855                 860                 


Glu Leu Gln Lys Ala Ile Glu Gly His Thr Lys Ser Gly Val Gln Leu 
865                 870                 875                 880 


Arg Pro Pro Leu Ala Ser Phe Arg Asn Thr Thr Ser Thr Arg Lys Ser 
                885                 890                 895     


Thr Gly Ala Pro Pro Ser Ser Ala Glu Asn Trp Asn Leu Pro Glu Asp 
            900                 905                 910         


Arg Pro Gly Ala Thr Gly Thr Gly Asp Val Ile Ala Ala Ser Pro Glu 
        915                 920                 925             


Thr Pro Val Pro Ser Pro Ser Pro Glu Pro Pro Leu Ser Leu Ala Pro 
    930                 935                 940                 


Gly Lys Val Glu Gly Glu Leu Glu Glu Leu Glu Leu Val Glu Ser Pro 
945                 950                 955                 960 


Gly Leu Glu Glu Glu Leu Ala Asp Ile Leu Gln Gly Pro Ser Leu Arg 
                965                 970                 975     


Ser Thr Asp Glu Glu Asp Glu Asp Glu Leu Ile Leu 
            980                 985             


<210>  22
<211>  746
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Asp Phe Leu Glu Glu Pro Ile Pro Gly Val Gly Thr Tyr Asp Asp 
1               5                   10                  15      


Phe Asn Thr Ile Asp Trp Val Arg Glu Lys Ser Arg Asp Arg Asp Arg 
            20                  25                  30          


His Arg Glu Ile Thr Asn Lys Ser Lys Glu Ser Thr Trp Ala Leu Ile 
        35                  40                  45              


His Ser Val Ser Asp Ala Phe Ser Gly Trp Leu Leu Met Leu Leu Ile 
    50                  55                  60                  


Gly Leu Leu Ser Gly Ser Leu Ala Gly Leu Ile Asp Ile Ser Ala His 
65                  70                  75                  80  


Trp Met Thr Asp Leu Lys Glu Gly Ile Cys Thr Gly Gly Phe Trp Phe 
                85                  90                  95      


Asn His Glu His Cys Cys Trp Asn Ser Glu His Val Thr Phe Glu Glu 
            100                 105                 110         


Arg Asp Lys Cys Pro Glu Trp Asn Ser Trp Ser Gln Leu Ile Ile Ser 
        115                 120                 125             


Thr Asp Glu Gly Ala Phe Ala Tyr Ile Val Asn Tyr Phe Met Tyr Val 
    130                 135                 140                 


Leu Trp Ala Leu Leu Phe Ala Phe Leu Ala Val Ser Leu Val Lys Val 
145                 150                 155                 160 


Phe Ala Pro Tyr Ala Cys Gly Ser Gly Ile Pro Glu Ile Lys Thr Ile 
                165                 170                 175     


Leu Ser Gly Phe Ile Ile Arg Gly Tyr Leu Gly Lys Trp Thr Leu Val 
            180                 185                 190         


Ile Lys Thr Ile Thr Leu Val Leu Ala Val Ser Ser Gly Leu Ser Leu 
        195                 200                 205             


Gly Lys Glu Gly Pro Leu Val His Val Ala Cys Cys Cys Gly Asn Ile 
    210                 215                 220                 


Leu Cys His Cys Phe Asn Lys Tyr Arg Lys Asn Glu Ala Lys Arg Arg 
225                 230                 235                 240 


Glu Val Leu Ser Ala Ala Ala Ala Ala Gly Val Ser Val Ala Phe Gly 
                245                 250                 255     


Ala Pro Ile Gly Gly Val Leu Phe Ser Leu Glu Glu Val Ser Tyr Tyr 
            260                 265                 270         


Phe Pro Leu Lys Thr Leu Trp Arg Ser Phe Phe Ala Ala Leu Val Ala 
        275                 280                 285             


Ala Phe Thr Leu Arg Ser Ile Asn Pro Phe Gly Asn Ser Arg Leu Val 
    290                 295                 300                 


Leu Phe Tyr Val Glu Phe His Thr Pro Trp His Leu Phe Glu Leu Val 
305                 310                 315                 320 


Pro Phe Ile Leu Leu Gly Ile Phe Gly Gly Leu Trp Gly Ala Leu Phe 
                325                 330                 335     


Ile Arg Thr Asn Ile Ala Trp Cys Arg Lys Arg Lys Thr Thr Gln Leu 
            340                 345                 350         


Gly Lys Tyr Pro Val Ile Glu Val Leu Val Val Thr Ala Ile Thr Ala 
        355                 360                 365             


Ile Leu Ala Phe Pro Asn Glu Tyr Thr Arg Met Ser Thr Ser Glu Leu 
    370                 375                 380                 


Ile Ser Glu Leu Phe Asn Asp Cys Gly Leu Leu Asp Ser Ser Lys Leu 
385                 390                 395                 400 


Cys Asp Tyr Glu Asn Arg Phe Asn Thr Ser Lys Gly Gly Glu Leu Pro 
                405                 410                 415     


Asp Arg Pro Ala Gly Val Gly Val Tyr Ser Ala Met Trp Gln Leu Ala 
            420                 425                 430         


Leu Thr Leu Ile Leu Lys Ile Val Ile Thr Ile Phe Thr Phe Gly Met 
        435                 440                 445             


Lys Ile Pro Ser Gly Leu Phe Ile Pro Ser Met Ala Val Gly Ala Ile 
    450                 455                 460                 


Ala Gly Arg Leu Leu Gly Val Gly Met Glu Gln Leu Ala Tyr Tyr His 
465                 470                 475                 480 


Gln Glu Trp Thr Val Phe Asn Ser Trp Cys Ser Gln Gly Ala Asp Cys 
                485                 490                 495     


Ile Thr Pro Gly Leu Tyr Ala Met Val Gly Ala Ala Ala Cys Leu Gly 
            500                 505                 510         


Gly Val Thr Arg Met Thr Val Ser Leu Val Val Ile Met Phe Glu Leu 
        515                 520                 525             


Thr Gly Gly Leu Glu Tyr Ile Val Pro Leu Met Ala Ala Ala Met Thr 
    530                 535                 540                 


Ser Lys Trp Val Ala Asp Ala Leu Gly Arg Glu Gly Ile Tyr Asp Ala 
545                 550                 555                 560 


His Ile Arg Leu Asn Gly Tyr Pro Phe Leu Glu Ala Lys Glu Glu Phe 
                565                 570                 575     


Ala His Lys Thr Leu Ala Met Asp Val Met Lys Pro Arg Arg Asn Asp 
            580                 585                 590         


Pro Leu Leu Thr Val Leu Thr Gln Asp Ser Met Thr Val Glu Asp Val 
        595                 600                 605             


Glu Thr Ile Ile Ser Glu Thr Thr Tyr Ser Gly Phe Pro Val Val Val 
    610                 615                 620                 


Ser Arg Glu Ser Gln Arg Leu Val Gly Phe Val Leu Arg Arg Asp Leu 
625                 630                 635                 640 


Ile Ile Ser Ile Glu Asn Ala Arg Lys Lys Gln Asp Gly Val Val Ser 
                645                 650                 655     


Thr Ser Ile Ile Tyr Phe Thr Glu His Ser Pro Pro Leu Pro Pro Tyr 
            660                 665                 670         


Thr Pro Pro Thr Leu Lys Leu Arg Asn Ile Leu Asp Leu Ser Pro Phe 
        675                 680                 685             


Thr Val Thr Asp Leu Thr Pro Met Glu Ile Val Val Asp Ile Phe Arg 
    690                 695                 700                 


Lys Leu Gly Leu Arg Gln Cys Leu Val Thr His Asn Gly Arg Leu Leu 
705                 710                 715                 720 


Gly Ile Ile Thr Lys Lys Asp Val Leu Lys His Ile Ala Gln Met Ala 
                725                 730                 735     


Asn Gln Asp Pro Asp Ser Ile Leu Phe Asn 
            740                 745     


<210>  23
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Glu Glu Phe Val Gly Leu Arg Glu Gly Ser Ser Gly Asn Pro Val 
1               5                   10                  15      


Thr Leu Gln Glu Leu Trp Gly Pro Cys Pro Arg Ile Arg Arg Gly Ile 
            20                  25                  30          


Arg Gly Gly Leu Glu Trp Leu Lys Gln Lys Leu Phe Arg Leu Gly Glu 
        35                  40                  45              


Asp Trp Tyr Phe Leu Met Thr Leu Gly Val Leu Met Ala Leu Val Ser 
    50                  55                  60                  


Cys Ala Met Asp Leu Ala Val Glu Ser Val Val Arg Ala His Gln Trp 
65                  70                  75                  80  


Leu Tyr Arg Glu Ile Gly Asp Ser His Leu Leu Arg Tyr Leu Ser Trp 
                85                  90                  95      


Thr Val Tyr Pro Val Ala Leu Val Ser Phe Ser Ser Gly Phe Ser Gln 
            100                 105                 110         


Ser Ile Thr Pro Ser Ser Gly Gly Ser Gly Ile Pro Glu Val Lys Thr 
        115                 120                 125             


Met Leu Ala Gly Val Val Leu Glu Asp Tyr Leu Asp Ile Lys Asn Phe 
    130                 135                 140                 


Gly Ala Lys Val Val Gly Leu Ser Cys Thr Leu Ala Cys Gly Ser Thr 
145                 150                 155                 160 


Leu Phe Leu Gly Lys Val Gly Pro Phe Val His Leu Ser Val Met Met 
                165                 170                 175     


Ala Ala Tyr Leu Gly Arg Val Arg Thr Thr Thr Ile Gly Glu Pro Glu 
            180                 185                 190         


Asn Lys Ser Lys Gln Asn Glu Met Leu Val Ala Ala Ala Ala Val Gly 
        195                 200                 205             


Val Ala Thr Val Phe Ala Ala Pro Phe Ser Gly Val Leu Phe Ser Ile 
    210                 215                 220                 


Glu Val Met Ser Ser His Phe Ser Val Trp Asp Tyr Trp Arg Gly Phe 
225                 230                 235                 240 


Phe Ala Ala Thr Cys Gly Ala Phe Met Phe Arg Leu Leu Ala Val Phe 
                245                 250                 255     


Asn Ser Glu Gln Glu Thr Ile Thr Ser Leu Tyr Lys Thr Ser Phe Arg 
            260                 265                 270         


Val Asp Val Pro Phe Asp Leu Pro Glu Ile Phe Phe Phe Val Ala Leu 
        275                 280                 285             


Gly Gly Leu Cys Gly Ile Leu Gly Ser Ala Tyr Leu Phe Cys Gln Arg 
    290                 295                 300                 


Ile Phe Phe Gly Phe Ile Arg Asn Asn Arg Phe Ser Ser Lys Leu Leu 
305                 310                 315                 320 


Ala Thr Ser Lys Pro Val Tyr Ser Ala Leu Ala Thr Leu Val Leu Ala 
                325                 330                 335     


Ser Ile Thr Tyr Pro Pro Ser Ala Gly Arg Phe Leu Ala Ser Arg Leu 
            340                 345                 350         


Ser Met Lys Gln His Leu Asp Ser Leu Phe Asp Asn His Ser Trp Ala 
        355                 360                 365             


Leu Met Thr Gln Asn Ser Ser Pro Pro Trp Pro Glu Glu Leu Asp Pro 
    370                 375                 380                 


Gln His Leu Trp Trp Glu Trp Tyr His Pro Arg Phe Thr Ile Phe Gly 
385                 390                 395                 400 


Thr Leu Ala Phe Phe Leu Val Met Lys Phe Trp Met Leu Ile Leu Ala 
                405                 410                 415     


Thr Thr Ile Pro Met Pro Ala Gly Tyr Phe Met Pro Ile Phe Val Tyr 
            420                 425                 430         


Gly Ala Ala Ile Gly Arg Leu Phe Gly Glu Thr Leu Ser Phe Ile Phe 
        435                 440                 445             


Pro Glu Gly Ile Val Ala Gly Gly Ile Thr Asn Pro Ile Met Pro Gly 
    450                 455                 460                 


Gly Tyr Ala Leu Ala Gly Ala Ala Ala Phe Ser Gly Ala Val Thr His 
465                 470                 475                 480 


Thr Ile Ser Thr Ala Leu Leu Ala Phe Glu Val Thr Gly Gln Ile Val 
                485                 490                 495     


His Ala Leu Pro Val Leu Met Ala Val Leu Ala Ala Asn Ala Ile Ala 
            500                 505                 510         


Gln Ser Cys Gln Pro Ser Phe Tyr Asp Gly Thr Val Ile Val Lys Lys 
        515                 520                 525             


Leu Pro Tyr Leu Pro Arg Ile Leu Gly Arg Asn Ile Gly Ser His Arg 
    530                 535                 540                 


Val Arg Val Glu His Phe Met Asn His Ser Ile Thr Thr Leu Ala Lys 
545                 550                 555                 560 


Asp Met Pro Leu Glu Glu Val Val Lys Val Val Thr Ser Thr Asp Val 
                565                 570                 575     


Ala Lys Tyr Pro Leu Val Glu Ser Thr Glu Ser Gln Ile Leu Val Gly 
            580                 585                 590         


Ile Val Arg Arg Ala Gln Leu Val Gln Ala Leu Lys Ala Glu Pro Pro 
        595                 600                 605             


Ser Trp Ala Pro Gly His Gln Gln Cys Leu Gln Asp Ile Leu Ala Ala 
    610                 615                 620                 


Gly Cys Pro Thr Glu Pro Val Thr Leu Lys Leu Ser Pro Glu Thr Ser 
625                 630                 635                 640 


Leu His Glu Ala His Asn Leu Phe Glu Leu Leu Asn Leu His Ser Leu 
                645                 650                 655     


Phe Val Thr Ser Arg Gly Arg Ala Val Gly Cys Val Ser Trp Val Glu 
            660                 665                 670         


Met Lys Lys Ala Ile Ser Asn Leu Thr Asn Pro Pro Ala Pro Lys 
        675                 680                 685         


<210>  24
<211>  438
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Gly Gly Cys Ala Gly Ser Arg Arg Arg Phe Ser Asp Ser Glu Gly 
1               5                   10                  15      


Glu Glu Thr Val Pro Glu Pro Arg Leu Pro Leu Leu Asp His Gln Gly 
            20                  25                  30          


Ala His Trp Lys Asn Ala Val Gly Phe Trp Leu Leu Gly Leu Cys Asn 
        35                  40                  45              


Asn Phe Ser Tyr Val Val Met Leu Ser Ala Ala His Asp Ile Leu Ser 
    50                  55                  60                  


His Lys Arg Thr Ser Gly Asn Gln Ser His Val Asp Pro Gly Pro Thr 
65                  70                  75                  80  


Pro Ile Pro His Asn Ser Ser Ser Arg Phe Asp Cys Asn Ser Val Ser 
                85                  90                  95      


Thr Ala Ala Val Leu Leu Ala Asp Ile Leu Pro Thr Leu Val Ile Lys 
            100                 105                 110         


Leu Leu Ala Pro Leu Gly Leu His Leu Leu Pro Tyr Ser Pro Arg Val 
        115                 120                 125             


Leu Val Ser Gly Ile Cys Ala Ala Gly Ser Phe Val Leu Val Ala Phe 
    130                 135                 140                 


Ser His Ser Val Gly Thr Ser Leu Cys Gly Val Val Phe Ala Ser Ile 
145                 150                 155                 160 


Ser Ser Gly Leu Gly Glu Val Thr Phe Leu Ser Leu Thr Ala Phe Tyr 
                165                 170                 175     


Pro Arg Ala Val Ile Ser Trp Trp Ser Ser Gly Thr Gly Gly Ala Gly 
            180                 185                 190         


Leu Leu Gly Ala Leu Ser Tyr Leu Gly Leu Thr Gln Ala Gly Leu Ser 
        195                 200                 205             


Pro Gln Gln Thr Leu Leu Ser Met Leu Gly Ile Pro Ala Leu Leu Leu 
    210                 215                 220                 


Ala Ser Tyr Phe Leu Leu Leu Thr Ser Pro Glu Ala Gln Asp Pro Gly 
225                 230                 235                 240 


Gly Glu Glu Glu Ala Glu Ser Ala Ala Arg Gln Pro Leu Ile Arg Thr 
                245                 250                 255     


Glu Ala Pro Glu Ser Lys Pro Gly Ser Ser Ser Ser Leu Ser Leu Arg 
            260                 265                 270         


Glu Arg Trp Thr Val Phe Lys Gly Leu Leu Trp Tyr Ile Val Pro Leu 
        275                 280                 285             


Val Val Val Tyr Phe Ala Glu Tyr Phe Ile Asn Gln Gly Leu Phe Glu 
    290                 295                 300                 


Leu Leu Phe Phe Trp Asn Thr Ser Leu Ser His Ala Gln Gln Tyr Arg 
305                 310                 315                 320 


Trp Tyr Gln Met Leu Tyr Gln Ala Gly Val Phe Ala Ser Arg Ser Ser 
                325                 330                 335     


Leu Arg Cys Cys Arg Ile Arg Phe Thr Trp Ala Leu Ala Leu Leu Gln 
            340                 345                 350         


Cys Leu Asn Leu Val Phe Leu Leu Ala Asp Val Trp Phe Gly Phe Leu 
        355                 360                 365             


Pro Ser Ile Tyr Leu Val Phe Leu Ile Ile Leu Tyr Glu Gly Leu Leu 
    370                 375                 380                 


Gly Gly Ala Ala Tyr Val Asn Thr Phe His Asn Ile Ala Leu Glu Thr 
385                 390                 395                 400 


Ser Asp Glu His Arg Glu Phe Ala Met Ala Ala Thr Cys Ile Ser Asp 
                405                 410                 415     


Thr Leu Gly Ile Ser Leu Ser Gly Leu Leu Ala Leu Pro Leu His Asp 
            420                 425                 430         


Phe Leu Cys Gln Leu Ser 
        435             


<210>  25
<211>  690
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Lys Leu Ser Met Lys Asn Asn Ile Ile Asn Thr Gln Gln Ser Phe 
1               5                   10                  15      


Val Thr Met Pro Asn Val Ile Val Pro Asp Ile Glu Lys Glu Ile Arg 
            20                  25                  30          


Arg Met Glu Asn Gly Ala Cys Ser Ser Phe Ser Glu Asp Asp Asp Ser 
        35                  40                  45              


Ala Ser Thr Ser Glu Glu Ser Glu Asn Glu Asn Pro His Ala Arg Gly 
    50                  55                  60                  


Ser Phe Ser Tyr Lys Ser Leu Arg Lys Gly Gly Pro Ser Gln Arg Glu 
65                  70                  75                  80  


Gln Tyr Leu Pro Gly Ala Ile Ala Leu Phe Asn Val Asn Asn Ser Ser 
                85                  90                  95      


Asn Lys Asp Gln Glu Pro Glu Glu Lys Lys Lys Lys Lys Lys Glu Lys 
            100                 105                 110         


Lys Ser Lys Ser Asp Asp Lys Asn Glu Asn Lys Asn Asp Pro Glu Lys 
        115                 120                 125             


Lys Lys Lys Lys Lys Asp Lys Glu Lys Lys Lys Lys Glu Glu Lys Ser 
    130                 135                 140                 


Lys Asp Lys Lys Glu Glu Glu Lys Lys Glu Val Val Val Ile Asp Pro 
145                 150                 155                 160 


Ser Gly Asn Thr Tyr Tyr Asn Trp Leu Phe Cys Ile Thr Leu Pro Val 
                165                 170                 175     


Met Tyr Asn Trp Thr Met Val Ile Ala Arg Ala Cys Phe Asp Glu Leu 
            180                 185                 190         


Gln Ser Asp Tyr Leu Glu Tyr Trp Leu Ile Leu Asp Tyr Val Ser Asp 
        195                 200                 205             


Ile Val Tyr Leu Ile Asp Met Phe Val Arg Thr Arg Thr Gly Tyr Leu 
    210                 215                 220                 


Glu Gln Gly Leu Leu Val Lys Glu Glu Leu Lys Leu Ile Asn Lys Tyr 
225                 230                 235                 240 


Lys Ser Asn Leu Gln Phe Lys Leu Asp Val Leu Ser Leu Ile Pro Thr 
                245                 250                 255     


Asp Leu Leu Tyr Phe Lys Leu Gly Trp Asn Tyr Pro Glu Ile Arg Leu 
            260                 265                 270         


Asn Arg Leu Leu Arg Phe Ser Arg Met Phe Glu Phe Phe Gln Arg Thr 
        275                 280                 285             


Glu Thr Arg Thr Asn Tyr Pro Asn Ile Phe Arg Ile Ser Asn Leu Val 
    290                 295                 300                 


Met Tyr Ile Val Ile Ile Ile His Trp Asn Ala Cys Val Phe Tyr Ser 
305                 310                 315                 320 


Ile Ser Lys Ala Ile Gly Phe Gly Asn Asp Thr Trp Val Tyr Pro Asp 
                325                 330                 335     


Ile Asn Asp Pro Glu Phe Gly Arg Leu Ala Arg Lys Tyr Val Tyr Ser 
            340                 345                 350         


Leu Tyr Trp Ser Thr Leu Thr Leu Thr Thr Ile Gly Glu Thr Pro Pro 
        355                 360                 365             


Pro Val Arg Asp Ser Glu Tyr Val Phe Val Val Val Asp Phe Leu Ile 
    370                 375                 380                 


Gly Val Leu Ile Phe Ala Thr Ile Val Gly Asn Ile Gly Ser Met Ile 
385                 390                 395                 400 


Ser Asn Met Asn Ala Ala Arg Ala Glu Phe Gln Ala Arg Ile Asp Ala 
                405                 410                 415     


Ile Lys Gln Tyr Met His Phe Arg Asn Val Ser Lys Asp Met Glu Lys 
            420                 425                 430         


Arg Val Ile Lys Trp Phe Asp Tyr Leu Trp Thr Asn Lys Lys Thr Val 
        435                 440                 445             


Asp Glu Lys Glu Val Leu Lys Tyr Leu Pro Asp Lys Leu Arg Ala Glu 
    450                 455                 460                 


Ile Ala Ile Asn Val His Leu Asp Thr Leu Lys Lys Val Arg Ile Phe 
465                 470                 475                 480 


Ala Asp Cys Glu Ala Gly Leu Leu Val Glu Leu Val Leu Lys Leu Gln 
                485                 490                 495     


Pro Gln Val Tyr Ser Pro Gly Asp Tyr Ile Cys Lys Lys Gly Asp Ile 
            500                 505                 510         


Gly Arg Glu Met Tyr Ile Ile Lys Glu Gly Lys Leu Ala Val Val Ala 
        515                 520                 525             


Asp Asp Gly Val Thr Gln Phe Val Val Leu Ser Asp Gly Ser Tyr Phe 
    530                 535                 540                 


Gly Glu Ile Ser Ile Leu Asn Ile Lys Gly Ser Lys Ala Gly Asn Arg 
545                 550                 555                 560 


Arg Thr Ala Asn Ile Lys Ser Ile Gly Tyr Ser Asp Leu Phe Cys Leu 
                565                 570                 575     


Ser Lys Asp Asp Leu Met Glu Ala Leu Thr Glu Tyr Pro Asp Ala Lys 
            580                 585                 590         


Thr Met Leu Glu Glu Lys Gly Lys Gln Ile Leu Met Lys Asp Gly Leu 
        595                 600                 605             


Leu Asp Leu Asn Ile Ala Asn Ala Gly Ser Asp Pro Lys Asp Leu Glu 
    610                 615                 620                 


Glu Lys Val Thr Arg Met Glu Gly Ser Val Asp Leu Leu Gln Thr Arg 
625                 630                 635                 640 


Phe Ala Arg Ile Leu Ala Glu Tyr Glu Ser Met Gln Gln Lys Leu Lys 
                645                 650                 655     


Gln Arg Leu Thr Lys Val Glu Lys Phe Leu Lys Pro Leu Ile Asp Thr 
            660                 665                 670         


Glu Phe Ser Ser Ile Glu Gly Pro Gly Ala Glu Ser Gly Pro Ile Asp 
        675                 680                 685             


Ser Thr 
    690 


<210>  26
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Gly Pro Leu Arg Ala Pro Leu Leu Leu Leu Ala Ile Leu Ala 
1               5                   10                  15      


Val Ala Leu Ala Val Ser Pro Ala Ala Gly Ser Ser Pro Gly Lys Pro 
            20                  25                  30          


Pro Arg Leu Val Gly Gly Pro Met Asp Ala Ser Val Glu Glu Glu Gly 
        35                  40                  45              


Val Arg Arg Ala Leu Asp Phe Ala Val Gly Glu Tyr Asn Lys Ala Ser 
    50                  55                  60                  


Asn Asp Met Tyr His Ser Arg Ala Leu Gln Val Val Arg Ala Arg Lys 
65                  70                  75                  80  


Gln Ile Val Ala Gly Val Asn Tyr Phe Leu Asp Val Glu Leu Gly Arg 
                85                  90                  95      


Thr Thr Cys Thr Lys Thr Gln Pro Asn Leu Asp Asn Cys Pro Phe His 
            100                 105                 110         


Asp Gln Pro His Leu Lys Arg Lys Ala Phe Cys Ser Phe Gln Ile Tyr 
        115                 120                 125             


Ala Val Pro Trp Gln Gly Thr Met Thr Leu Ser Lys Ser Thr Cys Gln 
    130                 135                 140                 


Asp Ala 
145     


<210>  27
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Gly Gln Ile Glu Trp Ala Met Trp Ala Asn Glu Gln Ala Leu Ala 
1               5                   10                  15      


Ser Gly Leu Ile Leu Ile Thr Gly Gly Ile Val Ala Thr Ala Gly Arg 
            20                  25                  30          


Phe Thr Gln Trp Tyr Phe Gly Ala Tyr Ser Ile Val Ala Gly Val Phe 
        35                  40                  45              


Val Cys Leu Leu Glu Tyr Pro Arg Gly Lys Arg Lys Lys Gly Ser Thr 
    50                  55                  60                  


Met Glu Arg Trp Gly Gln Lys Tyr Met Thr Ala Val Val Lys Leu Phe 
65                  70                  75                  80  


Gly Pro Phe Thr Arg Asn Tyr Tyr Val Arg Ala Val Leu His Leu Leu 
                85                  90                  95      


Leu Ser Val Pro Ala Gly Phe Leu Leu Ala Thr Ile Leu Gly Thr Ala 
            100                 105                 110         


Cys Leu Ala Ile Ala Ser Gly Ile Tyr Leu Leu Ala Ala Val Arg Gly 
        115                 120                 125             


Glu Gln Trp Thr Pro Ile Glu Pro Lys Pro Arg Glu Arg Pro Gln Ile 
    130                 135                 140                 


Gly Gly Thr Ile Lys Gln Pro Pro Ser Asn Pro Pro Pro Arg Pro Pro 
145                 150                 155                 160 


Ala Glu Ala Arg Lys Lys Pro Ser Glu Glu Glu Ala Ala Val Ala Ala 
                165                 170                 175     


Gly Gly Pro Pro Gly Gly Pro Gln Val Asn Pro Ile Pro Val Thr Asp 
            180                 185                 190         


Glu Val Val 
        195 


<210>  28
<211>  503
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Val Leu Glu Met Leu Asn Pro Ile His Tyr Asn Ile Thr Ser Ile 
1               5                   10                  15      


Val Pro Glu Ala Met Pro Ala Ala Thr Met Pro Val Leu Leu Leu Thr 
            20                  25                  30          


Gly Leu Phe Leu Leu Val Trp Asn Tyr Glu Gly Thr Ser Ser Ile Pro 
        35                  40                  45              


Gly Pro Gly Tyr Cys Met Gly Ile Gly Pro Leu Ile Ser His Gly Arg 
    50                  55                  60                  


Phe Leu Trp Met Gly Ile Gly Ser Ala Cys Asn Tyr Tyr Asn Arg Val 
65                  70                  75                  80  


Tyr Gly Glu Phe Met Arg Val Trp Ile Ser Gly Glu Glu Thr Leu Ile 
                85                  90                  95      


Ile Ser Lys Ser Ser Ser Met Phe His Ile Met Lys His Asn His Tyr 
            100                 105                 110         


Ser Ser Arg Phe Gly Ser Lys Leu Gly Leu Gln Cys Ile Gly Met His 
        115                 120                 125             


Glu Lys Gly Ile Ile Phe Asn Asn Asn Pro Glu Leu Trp Lys Thr Thr 
    130                 135                 140                 


Arg Pro Phe Phe Met Lys Ala Leu Ser Gly Pro Gly Leu Val Arg Met 
145                 150                 155                 160 


Val Thr Val Cys Ala Glu Ser Leu Lys Thr His Leu Asp Arg Leu Glu 
                165                 170                 175     


Glu Val Thr Asn Glu Ser Gly Tyr Val Asp Val Leu Thr Leu Leu Arg 
            180                 185                 190         


Arg Val Met Leu Asp Thr Ser Asn Thr Leu Phe Leu Arg Ile Pro Leu 
        195                 200                 205             


Asp Glu Ser Ala Ile Val Val Lys Ile Gln Gly Tyr Phe Asp Ala Trp 
    210                 215                 220                 


Gln Ala Leu Leu Ile Lys Pro Asp Ile Phe Phe Lys Ile Ser Trp Leu 
225                 230                 235                 240 


Tyr Lys Lys Tyr Glu Lys Ser Val Lys Asp Leu Lys Asp Ala Ile Glu 
                245                 250                 255     


Val Leu Ile Ala Glu Lys Arg Arg Arg Ile Ser Thr Glu Glu Lys Leu 
            260                 265                 270         


Glu Glu Cys Met Asp Phe Ala Thr Glu Leu Ile Leu Ala Glu Lys Arg 
        275                 280                 285             


Gly Asp Leu Thr Arg Glu Asn Val Asn Gln Cys Ile Leu Glu Met Leu 
    290                 295                 300                 


Ile Ala Ala Pro Asp Thr Met Ser Val Ser Leu Phe Phe Met Leu Phe 
305                 310                 315                 320 


Leu Ile Ala Lys His Pro Asn Val Glu Glu Ala Ile Ile Lys Glu Ile 
                325                 330                 335     


Gln Thr Val Ile Gly Glu Arg Asp Ile Lys Ile Asp Asp Ile Gln Lys 
            340                 345                 350         


Leu Lys Val Met Glu Asn Phe Ile Tyr Glu Ser Met Arg Tyr Gln Pro 
        355                 360                 365             


Val Val Asp Leu Val Met Arg Lys Ala Leu Glu Asp Asp Val Ile Asp 
    370                 375                 380                 


Gly Tyr Pro Val Lys Lys Gly Thr Asn Ile Ile Leu Asn Ile Gly Arg 
385                 390                 395                 400 


Met His Arg Leu Glu Phe Phe Pro Lys Pro Asn Glu Phe Thr Leu Glu 
                405                 410                 415     


Asn Phe Ala Lys Asn Val Pro Tyr Arg Tyr Phe Gln Pro Phe Gly Phe 
            420                 425                 430         


Gly Pro Arg Gly Cys Ala Gly Lys Tyr Ile Ala Met Val Met Met Lys 
        435                 440                 445             


Ala Ile Leu Val Thr Leu Leu Arg Arg Phe His Val Lys Thr Leu Gln 
    450                 455                 460                 


Gly Gln Cys Val Glu Ser Ile Gln Lys Ile His Asp Leu Ser Leu His 
465                 470                 475                 480 


Pro Asp Glu Thr Lys Asn Met Leu Glu Met Ile Phe Thr Pro Arg Asn 
                485                 490                 495     


Ser Asp Arg Cys Leu Glu His 
            500             


<210>  29
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Gly Thr Ser Leu Ser Pro Asn Asp Pro Trp Pro Leu Asn Pro Leu 
1               5                   10                  15      


Ser Ile Gln Gln Thr Thr Leu Leu Leu Leu Leu Ser Val Leu Ala Thr 
            20                  25                  30          


Val His Val Gly Gln Arg Leu Leu Arg Gln Arg Arg Arg Gln Leu Arg 
        35                  40                  45              


Ser Ala Pro Pro Gly Pro Phe Ala Trp Pro Leu Ile Gly Asn Ala Ala 
    50                  55                  60                  


Ala Val Gly Gln Ala Ala His Leu Ser Phe Ala Arg Leu Ala Arg Arg 
65                  70                  75                  80  


Tyr Gly Asp Val Phe Gln Ile Arg Leu Gly Ser Cys Pro Ile Val Val 
                85                  90                  95      


Leu Asn Gly Glu Arg Ala Ile His Gln Ala Leu Val Gln Gln Gly Ser 
            100                 105                 110         


Ala Phe Ala Asp Arg Pro Ala Phe Ala Ser Phe Arg Val Val Ser Gly 
        115                 120                 125             


Gly Arg Ser Met Ala Phe Gly His Tyr Ser Glu His Trp Lys Val Gln 
    130                 135                 140                 


Arg Arg Ala Ala His Ser Met Met Arg Asn Phe Phe Thr Arg Gln Pro 
145                 150                 155                 160 


Arg Ser Arg Gln Val Leu Glu Gly His Val Leu Ser Glu Ala Arg Glu 
                165                 170                 175     


Leu Val Ala Leu Leu Val Arg Gly Ser Ala Asp Gly Ala Phe Leu Asp 
            180                 185                 190         


Pro Arg Pro Leu Thr Val Val Ala Val Ala Asn Val Met Ser Ala Val 
        195                 200                 205             


Cys Phe Gly Cys Arg Tyr Ser His Asp Asp Pro Glu Phe Arg Glu Leu 
    210                 215                 220                 


Leu Ser His Asn Glu Glu Phe Gly Arg Thr Val Gly Ala Gly Ser Leu 
225                 230                 235                 240 


Val Asp Val Met Pro Trp Leu Gln Tyr Phe Pro Asn Pro Val Arg Thr 
                245                 250                 255     


Val Phe Arg Glu Phe Glu Gln Leu Asn Arg Asn Phe Ser Asn Phe Ile 
            260                 265                 270         


Leu Asp Lys Phe Leu Arg His Cys Glu Ser Leu Arg Pro Gly Ala Ala 
        275                 280                 285             


Pro Arg Asp Met Met Asp Ala Phe Ile Leu Ser Ala Glu Lys Lys Ala 
    290                 295                 300                 


Ala Gly Asp Ser His Gly Gly Gly Ala Arg Leu Asp Leu Glu Asn Val 
305                 310                 315                 320 


Pro Ala Thr Ile Thr Asp Ile Phe Gly Ala Ser Gln Asp Thr Leu Ser 
                325                 330                 335     


Thr Ala Leu Gln Trp Leu Leu Leu Leu Phe Thr Arg Tyr Pro Asp Val 
            340                 345                 350         


Gln Thr Arg Val Gln Ala Glu Leu Asp Gln Val Val Gly Arg Asp Arg 
        355                 360                 365             


Leu Pro Cys Met Gly Asp Gln Pro Asn Leu Pro Tyr Val Leu Ala Phe 
    370                 375                 380                 


Leu Tyr Glu Ala Met Arg Phe Ser Ser Phe Val Pro Val Thr Ile Pro 
385                 390                 395                 400 


His Ala Thr Thr Ala Asn Thr Ser Val Leu Gly Tyr His Ile Pro Lys 
                405                 410                 415     


Asp Thr Val Val Phe Val Asn Gln Trp Ser Val Asn His Asp Pro Leu 
            420                 425                 430         


Lys Trp Pro Asn Pro Glu Asn Phe Asp Pro Ala Arg Phe Leu Asp Lys 
        435                 440                 445             


Asp Gly Leu Ile Asn Lys Asp Leu Thr Ser Arg Val Met Ile Phe Ser 
    450                 455                 460                 


Val Gly Lys Arg Arg Cys Ile Gly Glu Glu Leu Ser Lys Met Gln Leu 
465                 470                 475                 480 


Phe Leu Phe Ile Ser Ile Leu Ala His Gln Cys Asp Phe Arg Ala Asn 
                485                 490                 495     


Pro Asn Glu Pro Ala Lys Met Asn Phe Ser Tyr Gly Leu Thr Ile Lys 
            500                 505                 510         


Pro Lys Ser Phe Lys Val Asn Val Thr Leu Arg Glu Ser Met Glu Leu 
        515                 520                 525             


Leu Asp Ser Ala Val Gln Asn Leu Gln Ala Lys Glu Thr Cys Gln 
    530                 535                 540             


<210>  30
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ala Pro Lys Lys Arg Pro Glu Thr Gln Lys Thr Ser Glu Ile Val 
1               5                   10                  15      


Leu Arg Pro Arg Asn Lys Arg Ser Arg Ser Pro Leu Glu Leu Glu Pro 
            20                  25                  30          


Glu Ala Lys Lys Leu Cys Ala Lys Gly Ser Gly Pro Ser Arg Arg Cys 
        35                  40                  45              


Asp Ser Asp Cys Leu Trp Val Gly Leu Ala Gly Pro Gln Ile Leu Pro 
    50                  55                  60                  


Pro Cys Arg Ser Ile Val Arg Thr Leu His Gln His Lys Leu Gly Arg 
65                  70                  75                  80  


Ala Ser Trp Pro Ser Val Gln Gln Gly Leu Gln Gln Ser Phe Leu His 
                85                  90                  95      


Thr Leu Asp Ser Tyr Arg Ile Leu Gln Lys Ala Ala Pro Phe Asp Arg 
            100                 105                 110         


Arg Ala Thr Ser Leu Ala Trp His Pro Thr His Pro Ser Thr Val Ala 
        115                 120                 125             


Val Gly Ser Lys Gly Gly Asp Ile Met Leu Trp Asn Phe Gly Ile Lys 
    130                 135                 140                 


Asp Lys Pro Thr Phe Ile Lys Gly Ile Gly Ala Gly Gly Ser Ile Thr 
145                 150                 155                 160 


Gly Leu Lys Phe Asn Pro Leu Asn Thr Asn Gln Phe Tyr Ala Ser Ser 
                165                 170                 175     


Met Glu Gly Thr Thr Arg Leu Gln Asp Phe Lys Gly Asn Ile Leu Arg 
            180                 185                 190         


Val Phe Ala Ser Ser Asp Thr Ile Asn Ile Trp Phe Cys Ser Leu Asp 
        195                 200                 205             


Val Ser Ala Ser Ser Arg Met Val Val Thr Gly Asp Asn Val Gly Asn 
    210                 215                 220                 


Val Ile Leu Leu Asn Met Asp Gly Lys Glu Leu Trp Asn Leu Arg Met 
225                 230                 235                 240 


His Lys Lys Lys Val Thr His Val Ala Leu Asn Pro Cys Cys Asp Trp 
                245                 250                 255     


Phe Leu Ala Thr Ala Ser Val Asp Gln Thr Val Lys Ile Trp Asp Leu 
            260                 265                 270         


Arg Gln Val Arg Gly Lys Ala Ser Phe Leu Tyr Ser Leu Pro His Arg 
        275                 280                 285             


His Pro Val Asn Ala Ala Cys Phe Ser Pro Asp Gly Ala Arg Leu Leu 
    290                 295                 300                 


Thr Thr Asp Gln Lys Ser Glu Ile Arg Val Tyr Ser Ala Ser Gln Trp 
305                 310                 315                 320 


Asp Cys Pro Leu Gly Leu Ile Pro His Pro His Arg His Phe Gln His 
                325                 330                 335     


Leu Thr Pro Ile Lys Ala Ala Trp His Pro Arg Tyr Asn Leu Ile Val 
            340                 345                 350         


Val Gly Arg Tyr Pro Asp Pro Asn Phe Lys Ser Cys Thr Pro Tyr Glu 
        355                 360                 365             


Leu Arg Thr Ile Asp Val Phe Asp Gly Asn Ser Gly Lys Met Met Cys 
    370                 375                 380                 


Gln Leu Tyr Asp Pro Glu Ser Ser Gly Ile Ser Ser Leu Asn Glu Phe 
385                 390                 395                 400 


Asn Pro Met Gly Asp Thr Leu Ala Ser Ala Met Gly Tyr His Ile Leu 
                405                 410                 415     


Ile Trp Ser Gln Glu Glu Ala Arg Thr Arg Lys 
            420                 425         


<210>  31
<211>  764
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ile Glu Pro Phe Gly Asn Gln Tyr Ile Val Ala Arg Pro Val Tyr 
1               5                   10                  15      


Ser Thr Asn Ala Phe Glu Glu Asn His Lys Lys Thr Gly Arg His His 
            20                  25                  30          


Lys Thr Phe Leu Asp His Leu Lys Val Cys Cys Ser Cys Ser Pro Gln 
        35                  40                  45              


Lys Ala Lys Arg Ile Val Leu Ser Leu Phe Pro Ile Ala Ser Trp Leu 
    50                  55                  60                  


Pro Ala Tyr Arg Leu Lys Glu Trp Leu Leu Ser Asp Ile Val Ser Gly 
65                  70                  75                  80  


Ile Ser Thr Gly Ile Val Ala Val Leu Gln Gly Leu Ala Phe Ala Leu 
                85                  90                  95      


Leu Val Asp Ile Pro Pro Val Tyr Gly Leu Tyr Ala Ser Phe Phe Pro 
            100                 105                 110         


Ala Ile Ile Tyr Leu Phe Phe Gly Thr Ser Arg His Ile Ser Val Gly 
        115                 120                 125             


Pro Phe Pro Ile Leu Ser Met Met Val Gly Leu Ala Val Ser Gly Ala 
    130                 135                 140                 


Val Ser Lys Ala Val Pro Asp Arg Asn Ala Thr Thr Leu Gly Leu Pro 
145                 150                 155                 160 


Asn Asn Ser Asn Asn Ser Ser Leu Leu Asp Asp Glu Arg Val Arg Val 
                165                 170                 175     


Ala Ala Ala Ala Ser Val Thr Val Leu Ser Gly Ile Ile Gln Leu Ala 
            180                 185                 190         


Phe Gly Ile Leu Arg Ile Gly Phe Val Val Ile Tyr Leu Ser Glu Ser 
        195                 200                 205             


Leu Ile Ser Gly Phe Thr Thr Ala Ala Ala Val His Val Leu Val Ser 
    210                 215                 220                 


Gln Leu Lys Phe Ile Phe Gln Leu Thr Val Pro Ser His Thr Asp Pro 
225                 230                 235                 240 


Val Ser Ile Phe Lys Val Leu Tyr Ser Val Phe Ser Gln Ile Glu Lys 
                245                 250                 255     


Thr Asn Ile Ala Asp Leu Val Thr Ala Leu Ile Val Leu Leu Val Val 
            260                 265                 270         


Ser Ile Val Lys Glu Ile Asn Gln Arg Phe Lys Asp Lys Leu Pro Val 
        275                 280                 285             


Pro Ile Pro Ile Glu Phe Ile Met Thr Val Ile Ala Ala Gly Val Ser 
    290                 295                 300                 


Tyr Gly Cys Asp Phe Lys Asn Arg Phe Lys Val Ala Val Val Gly Asp 
305                 310                 315                 320 


Met Asn Pro Gly Phe Gln Pro Pro Ile Thr Pro Asp Val Glu Thr Phe 
                325                 330                 335     


Gln Asn Thr Val Gly Asp Cys Phe Gly Ile Ala Met Val Ala Phe Ala 
            340                 345                 350         


Val Ala Phe Ser Val Ala Ser Val Tyr Ser Leu Lys Tyr Asp Tyr Pro 
        355                 360                 365             


Leu Asp Gly Asn Gln Glu Leu Ile Ala Leu Gly Leu Gly Asn Ile Val 
    370                 375                 380                 


Cys Gly Val Phe Arg Gly Phe Ala Gly Ser Thr Ala Leu Ser Arg Ser 
385                 390                 395                 400 


Ala Val Gln Glu Ser Thr Gly Gly Lys Thr Gln Ile Ala Gly Leu Ile 
                405                 410                 415     


Gly Ala Ile Ile Val Leu Ile Val Val Leu Ala Ile Gly Phe Leu Leu 
            420                 425                 430         


Ala Pro Leu Gln Lys Ser Val Leu Ala Ala Leu Ala Leu Gly Asn Leu 
        435                 440                 445             


Lys Gly Met Leu Met Gln Phe Ala Glu Ile Gly Arg Leu Trp Arg Lys 
    450                 455                 460                 


Asp Lys Tyr Asp Cys Leu Ile Trp Ile Met Thr Phe Ile Phe Thr Ile 
465                 470                 475                 480 


Val Leu Gly Leu Gly Leu Gly Leu Ala Ala Ser Val Ala Phe Gln Leu 
                485                 490                 495     


Leu Thr Ile Val Phe Arg Thr Gln Phe Pro Lys Cys Ser Thr Leu Ala 
            500                 505                 510         


Asn Ile Gly Arg Thr Asn Ile Tyr Lys Asn Lys Lys Asp Tyr Tyr Asp 
        515                 520                 525             


Met Tyr Glu Pro Glu Gly Val Lys Ile Phe Arg Cys Pro Ser Pro Ile 
    530                 535                 540                 


Tyr Phe Ala Asn Ile Gly Phe Phe Arg Arg Lys Leu Ile Asp Ala Val 
545                 550                 555                 560 


Gly Phe Ser Pro Leu Arg Ile Leu Arg Lys Arg Asn Lys Ala Leu Arg 
                565                 570                 575     


Lys Ile Arg Lys Leu Gln Lys Gln Gly Leu Leu Gln Val Thr Pro Lys 
            580                 585                 590         


Gly Phe Ile Cys Thr Val Asp Thr Ile Lys Asp Ser Asp Glu Glu Leu 
        595                 600                 605             


Asp Asn Asn Gln Ile Glu Val Leu Asp Gln Pro Ile Asn Thr Thr Asp 
    610                 615                 620                 


Leu Pro Phe His Ile Asp Trp Asn Asp Asp Leu Pro Leu Asn Ile Glu 
625                 630                 635                 640 


Val Pro Lys Ile Ser Leu His Ser Leu Ile Leu Asp Phe Ser Ala Val 
                645                 650                 655     


Ser Phe Leu Asp Val Ser Ser Val Arg Gly Leu Lys Ser Ile Leu Gln 
            660                 665                 670         


Glu Phe Ile Arg Ile Lys Val Asp Val Tyr Ile Val Gly Thr Asp Asp 
        675                 680                 685             


Asp Phe Ile Glu Lys Leu Asn Arg Tyr Glu Phe Phe Asp Gly Glu Val 
    690                 695                 700                 


Lys Ser Ser Ile Phe Phe Leu Thr Ile His Asp Ala Val Leu His Ile 
705                 710                 715                 720 


Leu Met Lys Lys Asp Tyr Ser Thr Ser Lys Phe Asn Pro Ser Gln Glu 
                725                 730                 735     


Lys Asp Gly Lys Ile Asp Phe Thr Ile Asn Thr Asn Gly Gly Leu Arg 
            740                 745                 750         


Asn Arg Val Tyr Glu Val Pro Val Glu Thr Lys Phe 
        755                 760                 


<210>  32
<211>  739
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ser Ser Glu Ser Lys Glu Gln His Asn Val Ser Pro Arg Asp Ser 
1               5                   10                  15      


Ala Glu Gly Asn Asp Ser Tyr Pro Ser Gly Ile His Leu Glu Leu Gln 
            20                  25                  30          


Arg Glu Ser Ser Thr Asp Phe Lys Gln Phe Glu Thr Asn Asp Gln Cys 
        35                  40                  45              


Arg Pro Tyr His Arg Ile Leu Ile Glu Arg Gln Glu Lys Ser Asp Thr 
    50                  55                  60                  


Asn Phe Lys Glu Phe Val Ile Lys Lys Leu Gln Lys Asn Cys Gln Cys 
65                  70                  75                  80  


Ser Pro Ala Lys Ala Lys Asn Met Ile Leu Gly Phe Leu Pro Val Leu 
                85                  90                  95      


Gln Trp Leu Pro Lys Tyr Asp Leu Lys Lys Asn Ile Leu Gly Asp Val 
            100                 105                 110         


Met Ser Gly Leu Ile Val Gly Ile Leu Leu Val Pro Gln Ser Ile Ala 
        115                 120                 125             


Tyr Ser Leu Leu Ala Gly Gln Glu Pro Val Tyr Gly Leu Tyr Thr Ser 
    130                 135                 140                 


Phe Phe Ala Ser Ile Ile Tyr Phe Leu Leu Gly Thr Ser Arg His Ile 
145                 150                 155                 160 


Ser Val Gly Ile Phe Gly Val Leu Cys Leu Met Ile Gly Glu Thr Val 
                165                 170                 175     


Asp Arg Glu Leu Gln Lys Ala Gly Tyr Asp Asn Ala His Ser Ala Pro 
            180                 185                 190         


Ser Leu Gly Met Val Ser Asn Gly Ser Thr Leu Leu Asn His Thr Ser 
        195                 200                 205             


Asp Arg Ile Cys Asp Lys Ser Cys Tyr Ala Ile Met Val Gly Ser Thr 
    210                 215                 220                 


Val Thr Phe Ile Ala Gly Val Tyr Gln Val Ala Met Gly Phe Phe Gln 
225                 230                 235                 240 


Val Gly Phe Val Ser Val Tyr Leu Ser Asp Ala Leu Leu Ser Gly Phe 
                245                 250                 255     


Val Thr Gly Ala Ser Phe Thr Ile Leu Thr Ser Gln Ala Lys Tyr Leu 
            260                 265                 270         


Leu Gly Leu Asn Leu Pro Arg Thr Asn Gly Val Gly Ser Leu Ile Thr 
        275                 280                 285             


Thr Trp Ile His Val Phe Arg Asn Ile His Lys Thr Asn Leu Cys Asp 
    290                 295                 300                 


Leu Ile Thr Ser Leu Leu Cys Leu Leu Val Leu Leu Pro Thr Lys Glu 
305                 310                 315                 320 


Leu Asn Glu His Phe Lys Ser Lys Leu Lys Ala Pro Ile Pro Ile Glu 
                325                 330                 335     


Leu Val Val Val Val Ala Ala Thr Leu Ala Ser His Phe Gly Lys Leu 
            340                 345                 350         


His Glu Asn Tyr Asn Ser Ser Ile Ala Gly His Ile Pro Thr Gly Phe 
        355                 360                 365             


Met Pro Pro Lys Val Pro Glu Trp Asn Leu Ile Pro Ser Val Ala Val 
    370                 375                 380                 


Asp Ala Ile Ala Ile Ser Ile Ile Gly Phe Ala Ile Thr Val Ser Leu 
385                 390                 395                 400 


Ser Glu Met Phe Ala Lys Lys His Gly Tyr Thr Val Lys Ala Asn Gln 
                405                 410                 415     


Glu Met Tyr Ala Ile Gly Phe Cys Asn Ile Ile Pro Ser Phe Phe His 
            420                 425                 430         


Cys Phe Thr Thr Ser Ala Ala Leu Ala Lys Thr Leu Val Lys Glu Ser 
        435                 440                 445             


Thr Gly Cys His Thr Gln Leu Ser Gly Val Val Thr Ala Leu Val Leu 
    450                 455                 460                 


Leu Leu Val Leu Leu Val Ile Ala Pro Leu Phe Tyr Ser Leu Gln Lys 
465                 470                 475                 480 


Ser Val Leu Gly Val Ile Thr Ile Val Asn Leu Arg Gly Ala Leu Arg 
                485                 490                 495     


Lys Phe Arg Asp Leu Pro Lys Met Trp Ser Ile Ser Arg Met Asp Thr 
            500                 505                 510         


Val Ile Trp Phe Val Thr Met Leu Ser Ser Ala Leu Leu Ser Thr Glu 
        515                 520                 525             


Ile Gly Leu Leu Val Gly Val Cys Phe Ser Ile Phe Cys Val Ile Leu 
    530                 535                 540                 


Arg Thr Gln Lys Pro Lys Ser Ser Leu Leu Gly Leu Val Glu Glu Ser 
545                 550                 555                 560 


Glu Val Phe Glu Ser Val Ser Ala Tyr Lys Asn Leu Gln Ile Lys Pro 
                565                 570                 575     


Gly Ile Lys Ile Phe Arg Phe Val Ala Pro Leu Tyr Tyr Ile Asn Lys 
            580                 585                 590         


Glu Cys Phe Lys Ser Ala Leu Tyr Lys Gln Thr Val Asn Pro Ile Leu 
        595                 600                 605             


Ile Lys Val Ala Trp Lys Lys Ala Ala Lys Arg Lys Ile Lys Glu Lys 
    610                 615                 620                 


Val Val Thr Leu Gly Gly Ile Gln Asp Glu Met Ser Val Gln Leu Ser 
625                 630                 635                 640 


His Asp Pro Leu Glu Leu His Thr Ile Val Ile Asp Cys Ser Ala Ile 
                645                 650                 655     


Gln Phe Leu Asp Thr Ala Gly Ile His Thr Leu Lys Glu Val Arg Arg 
            660                 665                 670         


Asp Tyr Glu Ala Ile Gly Ile Gln Val Leu Leu Ala Gln Cys Asn Pro 
        675                 680                 685             


Thr Val Arg Asp Ser Leu Thr Asn Gly Glu Tyr Cys Lys Lys Glu Glu 
    690                 695                 700                 


Glu Asn Leu Leu Phe Tyr Ser Val Tyr Glu Ala Met Ala Phe Ala Glu 
705                 710                 715                 720 


Val Ser Lys Asn Gln Lys Gly Val Cys Val Pro Asn Gly Leu Ser Leu 
                725                 730                 735     


Ser Ser Asp 
            


<210>  33
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Gln Pro Pro Pro Ser Leu Cys Gly Arg Ala Leu Val Ala Leu Val 
1               5                   10                  15      


Leu Ala Cys Gly Leu Ser Arg Ile Trp Gly Glu Glu Arg Gly Phe Pro 
            20                  25                  30          


Pro Asp Arg Ala Thr Pro Leu Leu Gln Thr Ala Glu Ile Met Thr Pro 
        35                  40                  45              


Pro Thr Lys Thr Leu Trp Pro Lys Gly Ser Asn Ala Ser Leu Ala Arg 
    50                  55                  60                  


Ser Leu Ala Pro Ala Glu Val Pro Lys Gly Asp Arg Thr Ala Gly Ser 
65                  70                  75                  80  


Pro Pro Arg Thr Ile Ser Pro Pro Pro Cys Gln Gly Pro Ile Glu Ile 
                85                  90                  95      


Lys Glu Thr Phe Lys Tyr Ile Asn Thr Val Val Ser Cys Leu Val Phe 
            100                 105                 110         


Val Leu Gly Ile Ile Gly Asn Ser Thr Leu Leu Arg Ile Ile Tyr Lys 
        115                 120                 125             


Asn Lys Cys Met Arg Asn Gly Pro Asn Ile Leu Ile Ala Ser Leu Ala 
    130                 135                 140                 


Leu Gly Asp Leu Leu His Ile Val Ile Asp Ile Pro Ile Asn Val Tyr 
145                 150                 155                 160 


Lys Leu Leu Ala Glu Asp Trp Pro Phe Gly Ala Glu Met Cys Lys Leu 
                165                 170                 175     


Val Pro Phe Ile Gln Lys Ala Ser Val Gly Ile Thr Val Leu Ser Leu 
            180                 185                 190         


Cys Ala Leu Ser Ile Asp Arg Tyr Arg Ala Val Ala Ser Trp Ser Arg 
        195                 200                 205             


Ile Lys Gly Ile Gly Val Pro Lys Trp Thr Ala Val Glu Ile Val Leu 
    210                 215                 220                 


Ile Trp Val Val Ser Val Val Leu Ala Val Pro Glu Ala Ile Gly Phe 
225                 230                 235                 240 


Asp Ile Ile Thr Met Asp Tyr Lys Gly Ser Tyr Leu Arg Ile Cys Leu 
                245                 250                 255     


Leu His Pro Val Gln Lys Thr Ala Phe Met Gln Phe Tyr Lys Thr Ala 
            260                 265                 270         


Lys Asp Trp Trp Leu Phe Ser Phe Tyr Phe Cys Leu Pro Leu Ala Ile 
        275                 280                 285             


Thr Ala Phe Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Arg Lys Lys 
    290                 295                 300                 


Ser Gly Met Gln Ile Ala Leu Asn Asp His Leu Lys Gln Arg Arg Glu 
305                 310                 315                 320 


Val Ala Lys Thr Val Phe Cys Leu Val Leu Val Phe Ala Leu Cys Trp 
                325                 330                 335     


Leu Pro Leu His Leu Ser Arg Ile Leu Lys Leu Thr Leu Tyr Asn Gln 
            340                 345                 350         


Asn Asp Pro Asn Arg Cys Glu Leu Leu Ser Phe Leu Leu Val Leu Asp 
        355                 360                 365             


Tyr Ile Gly Ile Asn Met Ala Ser Leu Asn Ser Cys Ile Asn Pro Ile 
    370                 375                 380                 


Ala Leu Tyr Leu Val Ser Lys Arg Phe Lys Asn Cys Phe Lys Ser Cys 
385                 390                 395                 400 


Leu Cys Cys Trp Cys Gln Ser Phe Glu Glu Lys Gln Ser Leu Glu Glu 
                405                 410                 415     


Lys Gln Ser Cys Leu Lys Phe Lys Ala Asn Asp His Gly Tyr Asp Asn 
            420                 425                 430         


Phe Arg Ser Ser Asn Lys Tyr Ser Ser Ser 
        435                 440         


<210>  34
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Pro Leu His Val Lys Trp Pro Phe Pro Ala Val Pro Pro Leu Thr 
1               5                   10                  15      


Trp Thr Leu Ala Ser Ser Val Val Met Gly Leu Val Gly Thr Tyr Ser 
            20                  25                  30          


Cys Phe Trp Thr Lys Tyr Met Asn His Leu Thr Val His Asn Arg Glu 
        35                  40                  45              


Val Leu Tyr Glu Leu Ile Glu Lys Arg Gly Pro Ala Thr Pro Leu Ile 
    50                  55                  60                  


Thr Val Ser Asn His Gln Ser Cys Met Asp Asp Pro His Leu Trp Gly 
65                  70                  75                  80  


Ile Leu Lys Leu Arg His Ile Trp Asn Leu Lys Leu Met Arg Trp Thr 
                85                  90                  95      


Pro Ala Ala Ala Asp Ile Cys Phe Thr Lys Glu Leu His Ser His Phe 
            100                 105                 110         


Phe Ser Leu Gly Lys Cys Val Pro Val Cys Arg Gly Ala Glu Phe Phe 
        115                 120                 125             


Gln Ala Glu Asn Glu Gly Lys Gly Val Leu Asp Thr Gly Arg His Met 
    130                 135                 140                 


Pro Gly Ala Gly Lys Arg Arg Glu Lys Gly Asp Gly Val Tyr Gln Lys 
145                 150                 155                 160 


Gly Met Asp Phe Ile Leu Glu Lys Leu Asn His Gly Asp Trp Val His 
                165                 170                 175     


Ile Phe Pro Glu Gly Lys Val Asn Met Ser Ser Glu Phe Leu Arg Phe 
            180                 185                 190         


Lys Trp Gly Ile Gly Arg Leu Ile Ala Glu Cys His Leu Asn Pro Ile 
        195                 200                 205             


Ile Leu Pro Leu Trp His Val Gly Met Asn Asp Val Leu Pro Asn Ser 
    210                 215                 220                 


Pro Pro Tyr Phe Pro Arg Phe Gly Gln Lys Ile Thr Val Leu Ile Gly 
225                 230                 235                 240 


Lys Pro Phe Ser Ala Leu Pro Val Leu Glu Arg Leu Arg Ala Glu Asn 
                245                 250                 255     


Lys Ser Ala Val Glu Met Arg Lys Ala Leu Thr Asp Phe Ile Gln Glu 
            260                 265                 270         


Glu Phe Gln His Leu Lys Thr Gln Ala Glu Gln Leu His Asn His Leu 
        275                 280                 285             


Gln Pro Gly Arg 
    290         


<210>  35
<211>  625
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Asp Arg Gly Thr Leu Pro Leu Ala Val Ala Leu Leu Leu Ala Ser 
1               5                   10                  15      


Cys Ser Leu Ser Pro Thr Ser Leu Ala Glu Thr Val His Cys Asp Leu 
            20                  25                  30          


Gln Pro Val Gly Pro Glu Arg Gly Glu Val Thr Tyr Thr Thr Ser Gln 
        35                  40                  45              


Val Ser Lys Gly Cys Val Ala Gln Ala Pro Asn Ala Ile Leu Glu Val 
    50                  55                  60                  


His Val Leu Phe Leu Glu Phe Pro Thr Gly Pro Ser Gln Leu Glu Leu 
65                  70                  75                  80  


Thr Leu Gln Ala Ser Lys Gln Asn Gly Thr Trp Pro Arg Glu Val Leu 
                85                  90                  95      


Leu Val Leu Ser Val Asn Ser Ser Val Phe Leu His Leu Gln Ala Leu 
            100                 105                 110         


Gly Ile Pro Leu His Leu Ala Tyr Asn Ser Ser Leu Val Thr Phe Gln 
        115                 120                 125             


Glu Pro Pro Gly Val Asn Thr Thr Glu Leu Pro Ser Phe Pro Lys Thr 
    130                 135                 140                 


Gln Ile Leu Glu Trp Ala Ala Glu Arg Gly Pro Ile Thr Ser Ala Ala 
145                 150                 155                 160 


Glu Leu Asn Asp Pro Gln Ser Ile Leu Leu Arg Leu Gly Gln Ala Gln 
                165                 170                 175     


Gly Ser Leu Ser Phe Cys Met Leu Glu Ala Ser Gln Asp Met Gly Arg 
            180                 185                 190         


Thr Leu Glu Trp Arg Pro Arg Thr Pro Ala Leu Val Arg Gly Cys His 
        195                 200                 205             


Leu Glu Gly Val Ala Gly His Lys Glu Ala His Ile Leu Arg Val Leu 
    210                 215                 220                 


Pro Gly His Ser Ala Gly Pro Arg Thr Val Thr Val Lys Val Glu Leu 
225                 230                 235                 240 


Ser Cys Ala Pro Gly Asp Leu Asp Ala Val Leu Ile Leu Gln Gly Pro 
                245                 250                 255     


Pro Tyr Val Ser Trp Leu Ile Asp Ala Asn His Asn Met Gln Ile Trp 
            260                 265                 270         


Thr Thr Gly Glu Tyr Ser Phe Lys Ile Phe Pro Glu Lys Asn Ile Arg 
        275                 280                 285             


Gly Phe Lys Leu Pro Asp Thr Pro Gln Gly Leu Leu Gly Glu Ala Arg 
    290                 295                 300                 


Met Leu Asn Ala Ser Ile Val Ala Ser Phe Val Glu Leu Pro Leu Ala 
305                 310                 315                 320 


Ser Ile Val Ser Leu His Ala Ser Ser Cys Gly Gly Arg Leu Gln Thr 
                325                 330                 335     


Ser Pro Ala Pro Ile Gln Thr Thr Pro Pro Lys Asp Thr Cys Ser Pro 
            340                 345                 350         


Glu Leu Leu Met Ser Leu Ile Gln Thr Lys Cys Ala Asp Asp Ala Met 
        355                 360                 365             


Thr Leu Val Leu Lys Lys Glu Leu Val Ala His Leu Lys Cys Thr Ile 
    370                 375                 380                 


Thr Gly Leu Thr Phe Trp Asp Pro Ser Cys Glu Ala Glu Asp Arg Gly 
385                 390                 395                 400 


Asp Lys Phe Val Leu Arg Ser Ala Tyr Ser Ser Cys Gly Met Gln Val 
                405                 410                 415     


Ser Ala Ser Met Ile Ser Asn Glu Ala Val Val Asn Ile Leu Ser Ser 
            420                 425                 430         


Ser Ser Pro Gln Arg Lys Lys Val His Cys Leu Asn Met Asp Ser Leu 
        435                 440                 445             


Ser Phe Gln Leu Gly Leu Tyr Leu Ser Pro His Phe Leu Gln Ala Ser 
    450                 455                 460                 


Asn Thr Ile Glu Pro Gly Gln Gln Ser Phe Val Gln Val Arg Val Ser 
465                 470                 475                 480 


Pro Ser Val Ser Glu Phe Leu Leu Gln Leu Asp Ser Cys His Leu Asp 
                485                 490                 495     


Leu Gly Pro Glu Gly Gly Thr Val Glu Leu Ile Gln Gly Arg Ala Ala 
            500                 505                 510         


Lys Gly Asn Cys Val Ser Leu Leu Ser Pro Ser Pro Glu Gly Asp Pro 
        515                 520                 525             


Arg Phe Ser Phe Leu Leu His Phe Tyr Thr Val Pro Ile Pro Lys Thr 
    530                 535                 540                 


Gly Thr Leu Ser Cys Thr Val Ala Leu Arg Pro Lys Thr Gly Ser Gln 
545                 550                 555                 560 


Asp Gln Glu Val His Arg Thr Val Phe Met Arg Leu Asn Ile Ile Ser 
                565                 570                 575     


Pro Asp Leu Ser Gly Cys Thr Ser Lys Gly Leu Val Leu Pro Ala Val 
            580                 585                 590         


Leu Gly Ile Thr Phe Gly Ala Phe Leu Ile Gly Ala Leu Leu Thr Ala 
        595                 600                 605             


Ala Leu Trp Tyr Ile Tyr Ser His Thr Arg Glu Tyr Pro Arg Pro Pro 
    610                 615                 620                 


Gln 
625 


<210>  36
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Asp His Leu Gly Ala Ser Leu Trp Pro Gln Val Gly Ser Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Gly Ala Ala Trp Ala Pro Pro Pro Asn Leu Pro Asp 
            20                  25                  30          


Pro Lys Phe Glu Ser Lys Ala Ala Leu Leu Ala Ala Arg Gly Pro Glu 
        35                  40                  45              


Glu Leu Leu Cys Phe Thr Glu Arg Leu Glu Asp Leu Val Cys Phe Trp 
    50                  55                  60                  


Glu Glu Ala Ala Ser Ala Gly Val Gly Pro Gly Asn Tyr Ser Phe Ser 
65                  70                  75                  80  


Tyr Gln Leu Glu Asp Glu Pro Trp Lys Leu Cys Arg Leu His Gln Ala 
                85                  90                  95      


Pro Thr Ala Arg Gly Ala Val Arg Phe Trp Cys Ser Leu Pro Thr Ala 
            100                 105                 110         


Asp Thr Ser Ser Phe Val Pro Leu Glu Leu Arg Val Thr Ala Ala Ser 
        115                 120                 125             


Gly Ala Pro Arg Tyr His Arg Val Ile His Ile Asn Glu Val Val Leu 
    130                 135                 140                 


Leu Asp Ala Pro Val Gly Leu Val Ala Arg Leu Ala Asp Glu Ser Gly 
145                 150                 155                 160 


His Val Val Leu Arg Trp Leu Pro Pro Pro Glu Thr Pro Met Thr Ser 
                165                 170                 175     


His Ile Arg Tyr Glu Val Asp Val Ser Ala Gly Asn Gly Ala Gly Ser 
            180                 185                 190         


Val Gln Arg Val Glu Ile Leu Glu Gly Arg Thr Glu Cys Val Leu Ser 
        195                 200                 205             


Asn Leu Arg Gly Arg Thr Arg Tyr Thr Phe Ala Val Arg Ala Arg Met 
    210                 215                 220                 


Ala Glu Pro Ser Phe Gly Gly Phe Trp Ser Ala Trp Ser Glu Pro Val 
225                 230                 235                 240 


Ser Leu Leu Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
                245                 250                 255     


Leu Ile Leu Val Val Ile Leu Val Leu Leu Thr Val Leu Ala Leu Leu 
            260                 265                 270         


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
        275                 280                 285             


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
    290                 295                 300                 


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
305                 310                 315                 320 


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
                325                 330                 335     


Arg Cys Trp Gly Thr Met Gln Ala Val Glu Pro Gly Thr Asp Asp Glu 
            340                 345                 350         


Gly Pro Leu Leu Glu Pro Val Gly Ser Glu His Ala Gln Asp Thr Tyr 
        355                 360                 365             


Leu Val Leu Asp Lys Trp Leu Leu Pro Arg Asn Pro Pro Ser Glu Asp 
    370                 375                 380                 


Leu Pro Gly Pro Gly Gly Ser Val Asp Ile Val Ala Met Asp Glu Gly 
385                 390                 395                 400 


Ser Glu Ala Ser Ser Cys Ser Ser Ala Leu Ala Ser Lys Pro Ser Pro 
                405                 410                 415     


Glu Gly Ala Ser Ala Ala Ser Phe Glu Tyr Thr Ile Leu Asp Pro Ser 
            420                 425                 430         


Ser Gln Leu Leu Arg Pro Trp Thr Leu Cys Pro Glu Leu Pro Pro Thr 
        435                 440                 445             


Pro Pro His Leu Lys Tyr Leu Tyr Leu Val Val Ser Asp Ser Gly Ile 
    450                 455                 460                 


Ser Thr Asp Tyr Ser Ser Gly Asp Ser Gln Gly Ala Gln Gly Gly Leu 
465                 470                 475                 480 


Ser Asp Gly Pro Tyr Ser Asn Pro Tyr Glu Asn Ser Leu Ile Pro Ala 
                485                 490                 495     


Ala Glu Pro Leu Pro Pro Ser Tyr Val Ala Cys Ser 
            500                 505             


<210>  37
<211>  746
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Gln Ala Lys Lys Arg Tyr Phe Ile Leu Leu Ser Ala Gly Ser Cys 
1               5                   10                  15      


Leu Ala Leu Leu Phe Tyr Phe Gly Gly Leu Gln Phe Arg Ala Ser Arg 
            20                  25                  30          


Ser His Ser Arg Arg Glu Glu His Ser Gly Arg Asn Gly Leu His His 
        35                  40                  45              


Pro Ser Pro Asp His Phe Trp Pro Arg Phe Pro Asp Ala Leu Arg Pro 
    50                  55                  60                  


Phe Val Pro Trp Asp Gln Leu Glu Asn Glu Asp Ser Ser Val His Ile 
65                  70                  75                  80  


Ser Pro Arg Gln Lys Arg Asp Ala Asn Ser Ser Ile Tyr Lys Gly Lys 
                85                  90                  95      


Lys Cys Arg Met Glu Ser Cys Phe Asp Phe Thr Leu Cys Lys Lys Asn 
            100                 105                 110         


Gly Phe Lys Val Tyr Val Tyr Pro Gln Gln Lys Gly Glu Lys Ile Ala 
        115                 120                 125             


Glu Ser Tyr Gln Asn Ile Leu Ala Ala Ile Glu Gly Ser Arg Phe Tyr 
    130                 135                 140                 


Thr Ser Asp Pro Ser Gln Ala Cys Leu Phe Val Leu Ser Leu Asp Thr 
145                 150                 155                 160 


Leu Asp Arg Asp Gln Leu Ser Pro Gln Tyr Val His Asn Leu Arg Ser 
                165                 170                 175     


Lys Val Gln Ser Leu His Leu Trp Asn Asn Gly Arg Asn His Leu Ile 
            180                 185                 190         


Phe Asn Leu Tyr Ser Gly Thr Trp Pro Asp Tyr Thr Glu Asp Val Gly 
        195                 200                 205             


Phe Asp Ile Gly Gln Ala Met Leu Ala Lys Ala Ser Ile Ser Thr Glu 
    210                 215                 220                 


Asn Phe Arg Pro Asn Phe Asp Val Ser Ile Pro Leu Phe Ser Lys Asp 
225                 230                 235                 240 


His Pro Arg Thr Gly Gly Glu Arg Gly Phe Leu Lys Phe Asn Thr Ile 
                245                 250                 255     


Pro Pro Leu Arg Lys Tyr Met Leu Val Phe Lys Gly Lys Arg Tyr Leu 
            260                 265                 270         


Thr Gly Ile Gly Ser Asp Thr Arg Asn Ala Leu Tyr His Val His Asn 
        275                 280                 285             


Gly Glu Asp Val Val Leu Leu Thr Thr Cys Lys His Gly Lys Asp Trp 
    290                 295                 300                 


Gln Lys His Lys Asp Ser Arg Cys Asp Arg Asp Asn Thr Glu Tyr Glu 
305                 310                 315                 320 


Lys Tyr Asp Tyr Arg Glu Met Leu His Asn Ala Thr Phe Cys Leu Val 
                325                 330                 335     


Pro Arg Gly Arg Arg Leu Gly Ser Phe Arg Phe Leu Glu Ala Leu Gln 
            340                 345                 350         


Ala Ala Cys Val Pro Val Met Leu Ser Asn Gly Trp Glu Leu Pro Phe 
        355                 360                 365             


Ser Glu Val Ile Asn Trp Asn Gln Ala Ala Val Ile Gly Asp Glu Arg 
    370                 375                 380                 


Leu Leu Leu Gln Ile Pro Ser Thr Ile Arg Ser Ile His Gln Asp Lys 
385                 390                 395                 400 


Ile Leu Ala Leu Arg Gln Gln Thr Gln Phe Leu Trp Glu Ala Tyr Phe 
                405                 410                 415     


Ser Ser Val Glu Lys Ile Val Leu Thr Thr Leu Glu Ile Ile Gln Asp 
            420                 425                 430         


Arg Ile Phe Lys His Ile Ser Arg Asn Ser Leu Ile Trp Asn Lys His 
        435                 440                 445             


Pro Gly Gly Leu Phe Val Leu Pro Gln Tyr Ser Ser Tyr Leu Gly Asp 
    450                 455                 460                 


Phe Pro Tyr Tyr Tyr Ala Asn Leu Gly Leu Lys Pro Pro Ser Lys Phe 
465                 470                 475                 480 


Thr Ala Val Ile His Ala Val Thr Pro Leu Val Ser Gln Ser Gln Pro 
                485                 490                 495     


Val Leu Lys Leu Leu Val Ala Ala Ala Lys Ser Gln Tyr Cys Ala Gln 
            500                 505                 510         


Ile Ile Val Leu Trp Asn Cys Asp Lys Pro Leu Pro Ala Lys His Arg 
        515                 520                 525             


Trp Pro Ala Thr Ala Val Pro Val Val Val Ile Glu Gly Glu Ser Lys 
    530                 535                 540                 


Val Met Ser Ser Arg Phe Leu Pro Tyr Asp Asn Ile Ile Thr Asp Ala 
545                 550                 555                 560 


Val Leu Ser Leu Asp Glu Asp Thr Val Leu Ser Thr Thr Glu Val Asp 
                565                 570                 575     


Phe Ala Phe Thr Val Trp Gln Ser Phe Pro Glu Arg Ile Val Gly Tyr 
            580                 585                 590         


Pro Ala Arg Ser His Phe Trp Asp Asn Ser Lys Glu Arg Trp Gly Tyr 
        595                 600                 605             


Thr Ser Lys Trp Thr Asn Asp Tyr Ser Met Val Leu Thr Gly Ala Ala 
    610                 615                 620                 


Ile Tyr His Lys Tyr Tyr His Tyr Leu Tyr Ser His Tyr Leu Pro Ala 
625                 630                 635                 640 


Ser Leu Lys Asn Met Val Asp Gln Leu Ala Asn Cys Glu Asp Ile Leu 
                645                 650                 655     


Met Asn Phe Leu Val Ser Ala Val Thr Lys Leu Pro Pro Ile Lys Val 
            660                 665                 670         


Thr Gln Lys Lys Gln Tyr Lys Glu Thr Met Met Gly Gln Thr Ser Arg 
        675                 680                 685             


Ala Ser Arg Trp Ala Asp Pro Asp His Phe Ala Gln Arg Gln Ser Cys 
    690                 695                 700                 


Met Asn Thr Phe Ala Ser Trp Phe Gly Tyr Met Pro Leu Ile His Ser 
705                 710                 715                 720 


Gln Met Arg Leu Asp Pro Val Leu Phe Lys Asp Gln Val Ser Ile Leu 
                725                 730                 735     


Arg Lys Lys Tyr Arg Asp Ile Glu Arg Leu 
            740                 745     


<210>  38
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Asp Thr Glu Ser Asn Arg Arg Ala Asn Leu Ala Leu Pro Gln Glu 
1               5                   10                  15      


Pro Ser Ser Val Pro Ala Phe Glu Val Leu Glu Ile Ser Pro Gln Glu 
            20                  25                  30          


Val Ser Ser Gly Arg Leu Leu Lys Ser Ala Ser Ser Pro Pro Leu His 
        35                  40                  45              


Thr Trp Leu Thr Val Leu Lys Lys Glu Gln Glu Phe Leu Gly Val Thr 
    50                  55                  60                  


Gln Ile Leu Thr Ala Met Ile Cys Leu Cys Phe Gly Thr Val Val Cys 
65                  70                  75                  80  


Ser Val Leu Asp Ile Ser His Ile Glu Gly Asp Ile Phe Ser Ser Phe 
                85                  90                  95      


Lys Ala Gly Tyr Pro Phe Trp Gly Ala Ile Phe Phe Ser Ile Ser Gly 
            100                 105                 110         


Met Leu Ser Ile Ile Ser Glu Arg Arg Asn Ala Thr Tyr Leu Val Arg 
        115                 120                 125             


Gly Ser Leu Gly Ala Asn Thr Ala Ser Ser Ile Ala Gly Gly Thr Gly 
    130                 135                 140                 


Ile Thr Ile Leu Ile Ile Asn Leu Lys Lys Ser Leu Ala Tyr Ile His 
145                 150                 155                 160 


Ile His Ser Cys Gln Lys Phe Phe Glu Thr Lys Cys Phe Met Ala Ser 
                165                 170                 175     


Phe Ser Thr Glu Ile Val Val Met Met Leu Phe Leu Thr Ile Leu Gly 
            180                 185                 190         


Leu Gly Ser Ala Val Ser Leu Thr Ile Cys Gly Ala Gly Glu Glu Leu 
        195                 200                 205             


Lys Gly Asn Lys Val Pro Glu Asp Arg Val Tyr Glu Glu Leu Asn Ile 
    210                 215                 220                 


Tyr Ser Ala Thr Tyr Ser Glu Leu Glu Asp Pro Gly Glu Met Ser Pro 
225                 230                 235                 240 


Pro Ile Asp Leu 
                


<210>  39
<211>  821
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              


Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu 
    50                  55                  60                  


Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
65                  70                  75                  80  


Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                85                  90                  95      


Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr 
            100                 105                 110         


Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile 
        115                 120                 125             


Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val 
    130                 135                 140                 


Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
145                 150                 155                 160 


Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys 
                165                 170                 175     


Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu 
            180                 185                 190         


Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             


Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
    210                 215                 220                 


Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile 
225                 230                 235                 240 


Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro 
                245                 250                 255     


Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly 
            260                 265                 270         


Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile 
        275                 280                 285             


Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp 
    290                 295                 300                 


Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr 
305                 310                 315                 320 


Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp 
                325                 330                 335     


Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe 
            340                 345                 350         


His Ser Ala Trp Leu Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu 
        355                 360                 365             


Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly 
    370                 375                 380                 


Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg Met 
385                 390                 395                 400 


Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His 
                405                 410                 415     


Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala 
            420                 425                 430         


Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr 
        435                 440                 445             


Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser 
    450                 455                 460                 


Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys 
465                 470                 475                 480 


Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val 
                485                 490                 495     


Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val 
            500                 505                 510         


Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu 
        515                 520                 525             


Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His 
    530                 535                 540                 


Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu 
545                 550                 555                 560 


Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu 
                565                 570                 575     


Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg 
            580                 585                 590         


Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr 
        595                 600                 605             


Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His 
    610                 615                 620                 


Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met 
625                 630                 635                 640 


Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr 
                645                 650                 655     


Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro 
            660                 665                 670         


Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser 
        675                 680                 685             


Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr 
    690                 695                 700                 


Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His 
705                 710                 715                 720 


Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met 
                725                 730                 735     


Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln 
            740                 745                 750         


Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu 
        755                 760                 765             


Tyr Leu Asp Leu Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro 
    770                 775                 780                 


Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro 
785                 790                 795                 800 


Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn 
                805                 810                 815     


Gly Ser Val Lys Thr 
            820     


<210>  40
<211>  806
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile 
1               5                   10                  15      


Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val 
            20                  25                  30          


Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln 
        35                  40                  45              


Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro 
    50                  55                  60                  


Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly 
65                  70                  75                  80  


Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val 
                85                  90                  95      


Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg 
            100                 105                 110         


Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala 
        115                 120                 125             


Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr 
    130                 135                 140                 


Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp 
145                 150                 155                 160 


Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys 
                165                 170                 175     


Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly 
            180                 185                 190         


Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His 
        195                 200                 205             


Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly 
    210                 215                 220                 


Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr 
225                 230                 235                 240 


Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
                245                 250                 255     


Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu 
            260                 265                 270         


Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu 
        275                 280                 285             


Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro 
    290                 295                 300                 


Tyr Val Thr Val Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu 
305                 310                 315                 320 


Leu Glu Val Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu 
                325                 330                 335     


Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala 
            340                 345                 350         


Trp Leu Val Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu 
        355                 360                 365             


Ala Gly Ser Val Tyr Ala Gly Ile Leu Ser Tyr Gly Val Gly Phe Phe 
    370                 375                 380                 


Leu Phe Ile Leu Val Val Ala Ala Val Thr Leu Cys Arg Leu Arg Ser 
385                 390                 395                 400 


Pro Pro Lys Lys Gly Leu Gly Ser Pro Thr Val His Lys Ile Ser Arg 
                405                 410                 415     


Phe Pro Leu Lys Arg Gln Val Ser Leu Glu Ser Asn Ala Ser Met Ser 
            420                 425                 430         


Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly 
        435                 440                 445             


Pro Thr Leu Ala Asn Val Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys 
    450                 455                 460                 


Trp Glu Leu Ser Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu 
465                 470                 475                 480 


Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile Gly Ile Asp Lys 
                485                 490                 495     


Asp Arg Ala Ala Lys Pro Val Thr Val Ala Val Lys Met Leu Lys Asp 
            500                 505                 510         


Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met 
        515                 520                 525             


Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala 
    530                 535                 540                 


Cys Thr Gln Gly Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys 
545                 550                 555                 560 


Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp 
                565                 570                 575     


Tyr Ser Phe Asp Thr Cys Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys 
            580                 585                 590         


Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu 
        595                 600                 605             


Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu 
    610                 615                 620                 


Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg 
625                 630                 635                 640 


Asp Val His Asn Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu 
                645                 650                 655     


Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr 
            660                 665                 670         


His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe 
        675                 680                 685             


Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe 
    690                 695                 700                 


Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr 
705                 710                 715                 720 


His Asp Leu Tyr Met Ile Met Arg Glu Cys Trp His Ala Ala Pro Ser 
                725                 730                 735     


Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Val Leu 
            740                 745                 750         


Thr Val Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu 
        755                 760                 765             


Gln Tyr Ser Pro Gly Gly Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly 
    770                 775                 780                 


Asp Asp Ser Val Phe Ala His Asp Leu Leu Pro Pro Ala Pro Pro Ser 
785                 790                 795                 800 


Ser Gly Gly Ser Arg Thr 
                805     


<210>  41
<211>  695
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Ala Leu Leu Leu Val Ser Leu Leu Ala Phe Leu Ser Leu Gly Ser 
1               5                   10                  15      


Gly Cys His His Arg Ile Cys His Cys Ser Asn Arg Val Phe Leu Cys 
            20                  25                  30          


Gln Glu Ser Lys Val Thr Glu Ile Pro Ser Asp Leu Pro Arg Asn Ala 
        35                  40                  45              


Ile Glu Leu Arg Phe Val Leu Thr Lys Leu Arg Val Ile Gln Lys Gly 
    50                  55                  60                  


Ala Phe Ser Gly Phe Gly Asp Leu Glu Lys Ile Glu Ile Ser Gln Asn 
65                  70                  75                  80  


Asp Val Leu Glu Val Ile Glu Ala Asp Val Phe Ser Asn Leu Pro Lys 
                85                  90                  95      


Leu His Glu Ile Arg Ile Glu Lys Ala Asn Asn Leu Leu Tyr Ile Asn 
            100                 105                 110         


Pro Glu Ala Phe Gln Asn Leu Pro Asn Leu Gln Tyr Leu Leu Ile Ser 
        115                 120                 125             


Asn Thr Gly Ile Lys His Leu Pro Asp Val His Lys Ile His Ser Leu 
    130                 135                 140                 


Gln Lys Val Leu Leu Asp Ile Gln Asp Asn Ile Asn Ile His Thr Ile 
145                 150                 155                 160 


Glu Arg Asn Ser Phe Val Gly Leu Ser Phe Glu Ser Val Ile Leu Trp 
                165                 170                 175     


Leu Asn Lys Asn Gly Ile Gln Glu Ile His Asn Cys Ala Phe Asn Gly 
            180                 185                 190         


Thr Gln Leu Asp Glu Leu Asn Leu Ser Asp Asn Asn Asn Leu Glu Glu 
        195                 200                 205             


Leu Pro Asn Asp Val Phe His Gly Ala Ser Gly Pro Val Ile Leu Asp 
    210                 215                 220                 


Ile Ser Arg Thr Arg Ile His Ser Leu Pro Ser Tyr Gly Leu Glu Asn 
225                 230                 235                 240 


Leu Lys Lys Leu Arg Ala Arg Ser Thr Tyr Asn Leu Lys Lys Leu Pro 
                245                 250                 255     


Thr Leu Glu Lys Leu Val Ala Leu Met Glu Ala Ser Leu Thr Tyr Pro 
            260                 265                 270         


Ser His Cys Cys Ala Phe Ala Asn Trp Arg Arg Gln Ile Ser Glu Leu 
        275                 280                 285             


His Pro Ile Cys Asn Lys Ser Ile Leu Arg Gln Glu Val Asp Tyr Met 
    290                 295                 300                 


Thr Gln Ala Arg Gly Gln Arg Ser Ser Leu Ala Glu Asp Asn Glu Ser 
305                 310                 315                 320 


Ser Tyr Ser Arg Gly Phe Asp Met Thr Tyr Thr Glu Phe Asp Tyr Asp 
                325                 330                 335     


Leu Cys Asn Glu Val Val Asp Val Thr Cys Ser Pro Lys Pro Asp Ala 
            340                 345                 350         


Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Asn Ile Leu Arg Val Leu 
        355                 360                 365             


Ile Trp Phe Ile Ser Ile Leu Ala Ile Thr Gly Asn Ile Ile Val Leu 
    370                 375                 380                 


Val Ile Leu Thr Thr Ser Gln Tyr Lys Leu Thr Val Pro Arg Phe Leu 
385                 390                 395                 400 


Met Cys Asn Leu Ala Phe Ala Asp Leu Cys Ile Gly Ile Tyr Leu Leu 
                405                 410                 415     


Leu Ile Ala Ser Val Asp Ile His Thr Lys Ser Gln Tyr His Asn Tyr 
            420                 425                 430         


Ala Ile Asp Trp Gln Thr Gly Ala Gly Cys Asp Ala Ala Gly Phe Phe 
        435                 440                 445             


Thr Val Phe Ala Ser Glu Leu Ser Val Tyr Thr Leu Thr Ala Ile Thr 
    450                 455                 460                 


Leu Glu Arg Trp His Thr Ile Thr His Ala Met Gln Leu Asp Cys Lys 
465                 470                 475                 480 


Val Gln Leu Arg His Ala Ala Ser Val Met Val Met Gly Trp Ile Phe 
                485                 490                 495     


Ala Phe Ala Ala Ala Leu Phe Pro Ile Phe Gly Ile Ser Ser Tyr Met 
            500                 505                 510         


Lys Val Ser Ile Cys Leu Pro Met Asp Ile Asp Ser Pro Leu Ser Gln 
        515                 520                 525             


Leu Tyr Val Met Ser Leu Leu Val Leu Asn Val Leu Ala Phe Val Val 
    530                 535                 540                 


Ile Cys Gly Cys Tyr Ile His Ile Tyr Leu Thr Val Arg Asn Pro Asn 
545                 550                 555                 560 


Ile Val Ser Ser Ser Ser Asp Thr Arg Ile Ala Lys Arg Met Ala Met 
                565                 570                 575     


Leu Ile Phe Thr Asp Phe Leu Cys Met Ala Pro Ile Ser Phe Phe Ala 
            580                 585                 590         


Ile Ser Ala Ser Leu Lys Val Pro Leu Ile Thr Val Ser Lys Ala Lys 
        595                 600                 605             


Ile Leu Leu Val Leu Phe His Pro Ile Asn Ser Cys Ala Asn Pro Phe 
    610                 615                 620                 


Leu Tyr Ala Ile Phe Thr Lys Asn Phe Arg Arg Asp Phe Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Lys Cys Gly Cys Tyr Glu Met Gln Ala Gln Ile Tyr Arg Thr 
                645                 650                 655     


Glu Thr Ser Ser Thr Val His Asn Thr His Pro Arg Asn Gly His Cys 
            660                 665                 670         


Ser Ser Ala Pro Arg Val Thr Ser Gly Ser Thr Tyr Ile Leu Val Pro 
        675                 680                 685             


Leu Ser His Leu Ala Gln Asn 
    690                 695 


<210>  42
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Trp Leu Arg Ser His Arg Gln Leu Cys Leu Ala Phe Leu Leu Val 
1               5                   10                  15      


Cys Val Leu Ser Val Ile Phe Phe Leu His Ile His Gln Asp Ser Phe 
            20                  25                  30          


Pro His Gly Leu Gly Leu Ser Ile Leu Cys Pro Asp Arg Arg Leu Val 
        35                  40                  45              


Thr Pro Pro Val Ala Ile Phe Cys Leu Pro Gly Thr Ala Met Gly Pro 
    50                  55                  60                  


Asn Ala Ser Ser Ser Cys Pro Gln His Pro Ala Ser Leu Ser Gly Thr 
65                  70                  75                  80  


Trp Thr Val Tyr Pro Asn Gly Arg Phe Gly Asn Gln Met Gly Gln Tyr 
                85                  90                  95      


Ala Thr Leu Leu Ala Leu Ala Gln Leu Asn Gly Arg Arg Ala Phe Ile 
            100                 105                 110         


Leu Pro Ala Met His Ala Ala Leu Ala Pro Val Phe Arg Ile Thr Leu 
        115                 120                 125             


Pro Val Leu Ala Pro Glu Val Asp Ser Arg Thr Pro Trp Arg Glu Leu 
    130                 135                 140                 


Gln Leu His Asp Trp Met Ser Glu Glu Tyr Ala Asp Leu Arg Asp Pro 
145                 150                 155                 160 


Phe Leu Lys Leu Ser Gly Phe Pro Cys Ser Trp Thr Phe Phe His His 
                165                 170                 175     


Leu Arg Glu Gln Ile Arg Arg Glu Phe Thr Leu His Asp His Leu Arg 
            180                 185                 190         


Glu Glu Ala Gln Ser Val Leu Gly Gln Leu Arg Leu Gly Arg Thr Gly 
        195                 200                 205             


Asp Arg Pro Arg Thr Phe Val Gly Val His Val Arg Arg Gly Asp Tyr 
    210                 215                 220                 


Leu Gln Val Met Pro Gln Arg Trp Lys Gly Val Val Gly Asp Ser Ala 
225                 230                 235                 240 


Tyr Leu Arg Gln Ala Met Asp Trp Phe Arg Ala Arg His Glu Ala Pro 
                245                 250                 255     


Val Phe Val Val Thr Ser Asn Gly Met Glu Trp Cys Lys Glu Asn Ile 
            260                 265                 270         


Asp Thr Ser Gln Gly Asp Val Thr Phe Ala Gly Asp Gly Gln Glu Ala 
        275                 280                 285             


Thr Pro Trp Lys Asp Phe Ala Leu Leu Thr Gln Cys Asn His Thr Ile 
    290                 295                 300                 


Met Thr Ile Gly Thr Phe Gly Phe Trp Ala Ala Tyr Leu Ala Gly Gly 
305                 310                 315                 320 


Asp Thr Val Tyr Leu Ala Asn Phe Thr Leu Pro Asp Ser Glu Phe Leu 
                325                 330                 335     


Lys Ile Phe Lys Pro Glu Ala Ala Phe Leu Pro Glu Trp Val Gly Ile 
            340                 345                 350         


Asn Ala Asp Leu Ser Pro Leu Trp Thr Leu Ala Lys Pro 
        355                 360                 365 


<210>  43
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Asp Pro Leu Gly Ala Ala Lys Pro Gln Trp Pro Trp Arg Arg Cys 
1               5                   10                  15      


Leu Ala Ala Leu Leu Phe Gln Leu Leu Val Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Arg Asp Asp Ala Thr Gly Ser Pro Arg Ala Pro 
        35                  40                  45              


Ser Gly Ser Ser Arg Gln Asp Thr Thr Pro Thr Arg Pro Thr Leu Leu 
    50                  55                  60                  


Ile Leu Leu Trp Thr Trp Pro Phe His Ile Pro Val Ala Leu Ser Arg 
65                  70                  75                  80  


Cys Ser Glu Met Val Pro Gly Thr Ala Asp Cys His Ile Thr Ala Asp 
                85                  90                  95      


Arg Lys Val Tyr Pro Gln Ala Asp Thr Val Ile Val His His Trp Asp 
            100                 105                 110         


Ile Met Ser Asn Pro Lys Ser Arg Leu Pro Pro Ser Pro Arg Pro Gln 
        115                 120                 125             


Gly Gln Arg Trp Ile Trp Phe Asn Leu Glu Pro Pro Pro Asn Cys Gln 
    130                 135                 140                 


His Leu Glu Ala Leu Asp Arg Tyr Phe Asn Leu Thr Met Ser Tyr Arg 
145                 150                 155                 160 


Ser Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser 
                165                 170                 175     


Gly Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu 
            180                 185                 190         


Val Ala Trp Ala Val Ser Asn Trp Lys Pro Asp Ser Ala Arg Val Arg 
        195                 200                 205             


Tyr Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg 
    210                 215                 220                 


Ser His Lys Pro Leu Pro Lys Gly Thr Met Met Glu Thr Leu Ser Arg 
225                 230                 235                 240 


Tyr Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile 
                245                 250                 255     


Thr Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val 
            260                 265                 270         


Val Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp 
        275                 280                 285             


Ala Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg 
    290                 295                 300                 


Tyr Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe 
305                 310                 315                 320 


Arg Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Asp 
                325                 330                 335     


Phe Cys Lys Ala Cys Trp Lys Leu Gln Gln Glu Ser Arg Tyr Gln Thr 
            340                 345                 350         


Val Arg Ser Ile Ala Ala Trp Phe Thr 
        355                 360     


<210>  44
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Asp Pro Leu Gly Pro Ala Lys Pro Gln Trp Ser Trp Arg Cys Cys 
1               5                   10                  15      


Leu Thr Thr Leu Leu Phe Gln Leu Leu Met Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Gln Asp Asp Pro Thr Val Tyr Pro Asn Gly Ser 
        35                  40                  45              


Arg Phe Pro Asp Ser Thr Gly Thr Pro Ala His Ser Ile Pro Leu Ile 
    50                  55                  60                  


Leu Leu Trp Thr Trp Pro Phe Asn Lys Pro Ile Ala Leu Pro Arg Cys 
65                  70                  75                  80  


Ser Glu Met Val Pro Gly Thr Ala Asp Cys Asn Ile Thr Ala Asp Arg 
                85                  90                  95      


Lys Val Tyr Pro Gln Ala Asp Ala Val Ile Val His His Arg Glu Val 
            100                 105                 110         


Met Tyr Asn Pro Ser Ala Gln Leu Pro Arg Ser Pro Arg Arg Gln Gly 
        115                 120                 125             


Gln Arg Trp Ile Trp Phe Ser Met Glu Ser Pro Ser His Cys Trp Gln 
    130                 135                 140                 


Leu Lys Ala Met Asp Gly Tyr Phe Asn Leu Thr Met Ser Tyr Arg Ser 
145                 150                 155                 160 


Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser Gly 
                165                 170                 175     


Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu Val 
            180                 185                 190         


Ala Trp Ala Val Ser Asn Trp Gly Pro Asn Ser Ala Arg Val Arg Tyr 
        195                 200                 205             


Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg Ser 
    210                 215                 220                 


His Lys Pro Leu Pro Gln Gly Thr Met Met Glu Thr Leu Ser Arg Tyr 
225                 230                 235                 240 


Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile Thr 
                245                 250                 255     


Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val Val 
            260                 265                 270         


Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp Ala 
        275                 280                 285             


Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg Tyr 
    290                 295                 300                 


Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe Arg 
305                 310                 315                 320 


Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Ala Phe 
                325                 330                 335     


Cys Lys Ala Cys Trp Lys Leu Gln Glu Glu Ser Arg Tyr Gln Thr Arg 
            340                 345                 350         


Gly Ile Ala Ala Trp Phe Thr 
        355                 


<210>  45
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Glu Glu Gly Met Asn Val Leu His Asp Phe Gly Ile Gln Ser Thr 
1               5                   10                  15      


His Tyr Leu Gln Val Asn Tyr Gln Asp Ser Gln Asp Trp Phe Ile Leu 
            20                  25                  30          


Val Ser Val Ile Ala Asp Leu Arg Asn Ala Phe Tyr Val Leu Phe Pro 
        35                  40                  45              


Ile Trp Phe His Leu Gln Glu Ala Val Gly Ile Lys Leu Leu Trp Val 
    50                  55                  60                  


Ala Val Ile Gly Asp Trp Leu Asn Leu Val Phe Lys Trp Ile Leu Phe 
65                  70                  75                  80  


Gly Gln Arg Pro Tyr Trp Trp Val Leu Asp Thr Asp Tyr Tyr Ser Asn 
                85                  90                  95      


Thr Ser Val Pro Leu Ile Lys Gln Phe Pro Val Thr Cys Glu Thr Gly 
            100                 105                 110         


Pro Gly Ser Pro Ser Gly His Ala Met Gly Thr Ala Gly Val Tyr Tyr 
        115                 120                 125             


Val Met Val Thr Ser Thr Leu Ser Ile Phe Gln Gly Lys Ile Lys Pro 
    130                 135                 140                 


Thr Tyr Arg Phe Arg Cys Leu Asn Val Ile Leu Trp Leu Gly Phe Trp 
145                 150                 155                 160 


Ala Val Gln Leu Asn Val Cys Leu Ser Arg Ile Tyr Leu Ala Ala His 
                165                 170                 175     


Phe Pro His Gln Val Val Ala Gly Val Leu Ser Gly Ile Ala Val Ala 
            180                 185                 190         


Glu Thr Phe Ser His Ile His Ser Ile Tyr Asn Ala Ser Leu Lys Lys 
        195                 200                 205             


Tyr Phe Leu Ile Thr Phe Phe Leu Phe Ser Phe Ala Ile Gly Phe Tyr 
    210                 215                 220                 


Leu Leu Leu Lys Gly Leu Gly Val Asp Leu Leu Trp Thr Leu Glu Lys 
225                 230                 235                 240 


Ala Gln Arg Trp Cys Glu Gln Pro Glu Trp Val His Ile Asp Thr Thr 
                245                 250                 255     


Pro Phe Ala Ser Leu Leu Lys Asn Leu Gly Thr Leu Phe Gly Leu Gly 
            260                 265                 270         


Leu Ala Leu Asn Ser Ser Met Tyr Arg Glu Ser Cys Lys Gly Lys Leu 
        275                 280                 285             


Ser Lys Trp Leu Pro Phe Arg Leu Ser Ser Ile Val Ala Ser Leu Val 
    290                 295                 300                 


Leu Leu His Val Phe Asp Ser Leu Lys Pro Pro Ser Gln Val Glu Leu 
305                 310                 315                 320 


Val Phe Tyr Val Leu Ser Phe Cys Lys Ser Ala Val Val Pro Leu Ala 
                325                 330                 335     


Ser Val Ser Val Ile Pro Tyr Cys Leu Ala Gln Val Leu Gly Gln Pro 
            340                 345                 350         


His Lys Lys Ser Leu 
        355         


<210>  46
<211>  952
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      


Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile Leu Leu 
            20                  25                  30          


His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val 
        35                  40                  45              


Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly 
    50                  55                  60                  


Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
65                  70                  75                  80  


Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
                85                  90                  95      


Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
            100                 105                 110         


Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
        115                 120                 125             


Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
    130                 135                 140                 


Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
145                 150                 155                 160 


Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
                165                 170                 175     


Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
            180                 185                 190         


Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu 
        195                 200                 205             


Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg 
    210                 215                 220                 


Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
225                 230                 235                 240 


Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
                245                 250                 255     


Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
            260                 265                 270         


Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
        275                 280                 285             


Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
    290                 295                 300                 


Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
305                 310                 315                 320 


Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
                325                 330                 335     


Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
            340                 345                 350         


Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
        355                 360                 365             


Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
    370                 375                 380                 


Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
385                 390                 395                 400 


Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
                405                 410                 415     


Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
            420                 425                 430         


Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
        435                 440                 445             


Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg 
    450                 455                 460                 


Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
465                 470                 475                 480 


Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
                485                 490                 495     


Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
            500                 505                 510         


Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
        515                 520                 525             


Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
    530                 535                 540                 


Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
545                 550                 555                 560 


Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
                565                 570                 575     


Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
            580                 585                 590         


Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
        595                 600                 605             


Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
    610                 615                 620                 


Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
625                 630                 635                 640 


Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
                645                 650                 655     


Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
            660                 665                 670         


Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
        675                 680                 685             


Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
    690                 695                 700                 


Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
705                 710                 715                 720 


Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
                725                 730                 735     


Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
            740                 745                 750         


Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
        755                 760                 765             


Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly 
    770                 775                 780                 


Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
785                 790                 795                 800 


Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
                805                 810                 815     


His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr 
            820                 825                 830         


Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr 
        835                 840                 845             


Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser 
    850                 855                 860                 


Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala 
865                 870                 875                 880 


Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly 
                885                 890                 895     


Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala 
            900                 905                 910         


Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr 
        915                 920                 925             


Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly 
    930                 935                 940                 


Glu Gln Phe Leu Val Ser Trp Cys 
945                 950         


<210>  47
<211>  685
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ala Glu Trp Leu Leu Ser Ala Ser Trp Gln Arg Arg Ala Lys Ala 
1               5                   10                  15      


Met Thr Ala Ala Ala Gly Ser Ala Gly Arg Ala Ala Val Pro Leu Leu 
            20                  25                  30          


Leu Cys Ala Leu Leu Ala Pro Gly Gly Ala Tyr Val Leu Asp Asp Ser 
        35                  40                  45              


Asp Gly Leu Gly Arg Glu Phe Asp Gly Ile Gly Ala Val Ser Gly Gly 
    50                  55                  60                  


Gly Ala Thr Ser Arg Leu Leu Val Asn Tyr Pro Glu Pro Tyr Arg Ser 
65                  70                  75                  80  


Gln Ile Leu Asp Tyr Leu Phe Lys Pro Asn Phe Gly Ala Ser Leu His 
                85                  90                  95      


Ile Leu Lys Val Glu Ile Gly Gly Asp Gly Gln Thr Thr Asp Gly Thr 
            100                 105                 110         


Glu Pro Ser His Met His Tyr Ala Leu Asp Glu Asn Tyr Phe Arg Gly 
        115                 120                 125             


Tyr Glu Trp Trp Leu Met Lys Glu Ala Lys Lys Arg Asn Pro Asn Ile 
    130                 135                 140                 


Thr Leu Ile Gly Leu Pro Trp Ser Phe Pro Gly Trp Leu Gly Lys Gly 
145                 150                 155                 160 


Phe Asp Trp Pro Tyr Val Asn Leu Gln Leu Thr Ala Tyr Tyr Val Val 
                165                 170                 175     


Thr Trp Ile Val Gly Ala Lys Arg Tyr His Asp Leu Asp Ile Asp Tyr 
            180                 185                 190         


Ile Gly Ile Trp Asn Glu Arg Ser Tyr Asn Ala Asn Tyr Ile Lys Ile 
        195                 200                 205             


Leu Arg Lys Met Leu Asn Tyr Gln Gly Leu Gln Arg Val Lys Ile Ile 
    210                 215                 220                 


Ala Ser Asp Asn Leu Trp Glu Ser Ile Ser Ala Ser Met Leu Leu Asp 
225                 230                 235                 240 


Ala Glu Leu Phe Lys Val Val Asp Val Ile Gly Ala His Tyr Pro Gly 
                245                 250                 255     


Thr His Ser Ala Lys Asp Ala Lys Leu Thr Gly Lys Lys Leu Trp Ser 
            260                 265                 270         


Ser Glu Asp Phe Ser Thr Leu Asn Ser Asp Met Gly Ala Gly Cys Trp 
        275                 280                 285             


Gly Arg Ile Leu Asn Gln Asn Tyr Ile Asn Gly Tyr Met Thr Ser Thr 
    290                 295                 300                 


Ile Ala Trp Asn Leu Val Ala Ser Tyr Tyr Glu Gln Leu Pro Tyr Gly 
305                 310                 315                 320 


Arg Cys Gly Leu Met Thr Ala Gln Glu Pro Trp Ser Gly His Tyr Val 
                325                 330                 335     


Val Glu Ser Pro Val Trp Val Ser Ala His Thr Thr Gln Phe Thr Gln 
            340                 345                 350         


Pro Gly Trp Tyr Tyr Leu Lys Thr Val Gly His Leu Glu Lys Gly Gly 
        355                 360                 365             


Ser Tyr Val Ala Leu Thr Asp Gly Leu Gly Asn Leu Thr Ile Ile Ile 
    370                 375                 380                 


Glu Thr Met Ser His Lys His Ser Lys Cys Ile Arg Pro Phe Leu Pro 
385                 390                 395                 400 


Tyr Phe Asn Val Ser Gln Gln Phe Ala Thr Phe Val Leu Lys Gly Ser 
                405                 410                 415     


Phe Ser Glu Ile Pro Glu Leu Gln Val Trp Tyr Thr Lys Leu Gly Lys 
            420                 425                 430         


Thr Ser Glu Arg Phe Leu Phe Lys Gln Leu Asp Ser Leu Trp Leu Leu 
        435                 440                 445             


Asp Ser Asp Gly Ser Phe Thr Leu Ser Leu His Glu Asp Glu Leu Phe 
    450                 455                 460                 


Thr Leu Thr Thr Leu Thr Thr Gly Arg Lys Gly Ser Tyr Pro Leu Pro 
465                 470                 475                 480 


Pro Lys Ser Gln Pro Phe Pro Ser Thr Tyr Lys Asp Asp Phe Asn Val 
                485                 490                 495     


Asp Tyr Pro Phe Phe Ser Glu Ala Pro Asn Phe Ala Asp Gln Thr Gly 
            500                 505                 510         


Val Phe Glu Tyr Phe Thr Asn Ile Glu Asp Pro Gly Glu His His Phe 
        515                 520                 525             


Thr Leu Arg Gln Val Leu Asn Gln Arg Pro Ile Thr Trp Ala Ala Asp 
    530                 535                 540                 


Ala Ser Asn Thr Ile Ser Ile Ile Gly Asp Tyr Asn Trp Thr Asn Leu 
545                 550                 555                 560 


Thr Ile Lys Cys Asp Val Tyr Ile Glu Thr Pro Asp Thr Gly Gly Val 
                565                 570                 575     


Phe Ile Ala Gly Arg Val Asn Lys Gly Gly Ile Leu Ile Arg Ser Ala 
            580                 585                 590         


Arg Gly Ile Phe Phe Trp Ile Phe Ala Asn Gly Ser Tyr Arg Val Thr 
        595                 600                 605             


Gly Asp Leu Ala Gly Trp Ile Ile Tyr Ala Leu Gly Arg Val Glu Val 
    610                 615                 620                 


Thr Ala Lys Lys Trp Tyr Thr Leu Thr Leu Thr Ile Lys Gly His Phe 
625                 630                 635                 640 


Thr Ser Gly Met Leu Asn Asp Lys Ser Leu Trp Thr Asp Ile Pro Val 
                645                 650                 655     


Asn Phe Pro Lys Asn Gly Trp Ala Ala Ile Gly Thr His Ser Phe Glu 
            660                 665                 670         


Phe Ala Gln Phe Asp Asn Phe Leu Val Glu Ala Thr Arg 
        675                 680                 685 


<210>  48
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Pro Pro Cys Gln Pro Gln Arg Pro Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Cys Gln Pro Gln Val Pro Ser Ala Gln Val Met Asp Phe Leu 
            20                  25                  30          


Phe Glu Lys Trp Lys Leu Tyr Gly Asp Gln Cys His His Asn Leu Ser 
        35                  40                  45              


Leu Leu Pro Pro Pro Thr Glu Leu Val Cys Asn Arg Thr Phe Asp Lys 
    50                  55                  60                  


Tyr Ser Cys Trp Pro Asp Thr Pro Ala Asn Thr Thr Ala Asn Ile Ser 
65                  70                  75                  80  


Cys Pro Trp Tyr Leu Pro Trp His His Lys Val Gln His Arg Phe Val 
                85                  90                  95      


Phe Lys Arg Cys Gly Pro Asp Gly Gln Trp Val Arg Gly Pro Arg Gly 
            100                 105                 110         


Gln Pro Trp Arg Asp Ala Ser Gln Cys Gln Met Asp Gly Glu Glu Ile 
        115                 120                 125             


Glu Val Gln Lys Glu Val Ala Lys Met Tyr Ser Ser Phe Gln Val Met 
    130                 135                 140                 


Tyr Thr Val Gly Tyr Ser Leu Ser Leu Gly Ala Leu Leu Leu Ala Leu 
145                 150                 155                 160 


Ala Ile Leu Gly Gly Leu Ser Lys Leu His Cys Thr Arg Asn Ala Ile 
                165                 170                 175     


His Ala Asn Leu Phe Ala Ser Phe Val Leu Lys Ala Ser Ser Val Leu 
            180                 185                 190         


Val Ile Asp Gly Leu Leu Arg Thr Arg Tyr Ser Gln Lys Ile Gly Asp 
        195                 200                 205             


Asp Leu Ser Val Ser Thr Trp Leu Ser Asp Gly Ala Val Ala Gly Cys 
    210                 215                 220                 


Arg Val Ala Ala Val Phe Met Gln Tyr Gly Ile Val Ala Asn Tyr Cys 
225                 230                 235                 240 


Trp Leu Leu Val Glu Gly Leu Tyr Leu His Asn Leu Leu Gly Leu Ala 
                245                 250                 255     


Thr Leu Pro Glu Arg Ser Phe Phe Ser Leu Tyr Leu Gly Ile Gly Trp 
            260                 265                 270         


Gly Ala Pro Met Leu Phe Val Val Pro Trp Ala Val Val Lys Cys Leu 
        275                 280                 285             


Phe Glu Asn Val Gln Cys Trp Thr Ser Asn Asp Asn Met Gly Phe Trp 
    290                 295                 300                 


Trp Ile Leu Arg Phe Pro Val Phe Leu Ala Ile Leu Ile Asn Phe Phe 
305                 310                 315                 320 


Ile Phe Val Arg Ile Val Gln Leu Leu Val Ala Lys Leu Arg Ala Arg 
                325                 330                 335     


Gln Met His His Thr Asp Tyr Lys Phe Arg Leu Ala Lys Ser Thr Leu 
            340                 345                 350         


Thr Leu Ile Pro Leu Leu Gly Val His Glu Val Val Phe Ala Phe Val 
        355                 360                 365             


Thr Asp Glu His Ala Gln Gly Thr Leu Arg Ser Ala Lys Leu Phe Phe 
    370                 375                 380                 


Asp Leu Phe Leu Ser Ser Phe Gln Gly Leu Leu Val Ala Val Leu Tyr 
385                 390                 395                 400 


Cys Phe Leu Asn Lys Glu Val Gln Ser Glu Leu Arg Arg Arg Trp His 
                405                 410                 415     


Arg Trp Arg Leu Gly Lys Val Leu Trp Glu Glu Arg Asn Thr Ser Asn 
            420                 425                 430         


His Arg Ala Ser Ser Ser Pro Gly His Gly Pro Pro Ser Lys Glu Leu 
        435                 440                 445             


Gln Phe Gly Arg Gly Gly Gly Ser Gln Asp Ser Ser Ala Glu Thr Pro 
    450                 455                 460                 


Leu Ala Gly Gly Leu Pro Arg Leu Ala Glu Ser Pro Phe 
465                 470                 475         


<210>  49
<211>  638
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Asp Leu Trp Gln Leu Leu Leu Thr Leu Ala Leu Ala Gly Ser Ser 
1               5                   10                  15      


Asp Ala Phe Ser Gly Ser Glu Ala Thr Ala Ala Ile Leu Ser Arg Ala 
            20                  25                  30          


Pro Trp Ser Leu Gln Ser Val Asn Pro Gly Leu Lys Thr Asn Ser Ser 
        35                  40                  45              


Lys Glu Pro Lys Phe Thr Lys Cys Arg Ser Pro Glu Arg Glu Thr Phe 
    50                  55                  60                  


Ser Cys His Trp Thr Asp Glu Val His His Gly Thr Lys Asn Leu Gly 
65                  70                  75                  80  


Pro Ile Gln Leu Phe Tyr Thr Arg Arg Asn Thr Gln Glu Trp Thr Gln 
                85                  90                  95      


Glu Trp Lys Glu Cys Pro Asp Tyr Val Ser Ala Gly Glu Asn Ser Cys 
            100                 105                 110         


Tyr Phe Asn Ser Ser Phe Thr Ser Ile Trp Ile Pro Tyr Cys Ile Lys 
        115                 120                 125             


Leu Thr Ser Asn Gly Gly Thr Val Asp Glu Lys Cys Phe Ser Val Asp 
    130                 135                 140                 


Glu Ile Val Gln Pro Asp Pro Pro Ile Ala Leu Asn Trp Thr Leu Leu 
145                 150                 155                 160 


Asn Val Ser Leu Thr Gly Ile His Ala Asp Ile Gln Val Arg Trp Glu 
                165                 170                 175     


Ala Pro Arg Asn Ala Asp Ile Gln Lys Gly Trp Met Val Leu Glu Tyr 
            180                 185                 190         


Glu Leu Gln Tyr Lys Glu Val Asn Glu Thr Lys Trp Lys Met Met Asp 
        195                 200                 205             


Pro Ile Leu Thr Thr Ser Val Pro Val Tyr Ser Leu Lys Val Asp Lys 
    210                 215                 220                 


Glu Tyr Glu Val Arg Val Arg Ser Lys Gln Arg Asn Ser Gly Asn Tyr 
225                 230                 235                 240 


Gly Glu Phe Ser Glu Val Leu Tyr Val Thr Leu Pro Gln Met Ser Gln 
                245                 250                 255     


Phe Thr Cys Glu Glu Asp Phe Tyr Phe Pro Trp Leu Leu Ile Ile Ile 
            260                 265                 270         


Phe Gly Ile Phe Gly Leu Thr Val Met Leu Phe Val Phe Leu Phe Ser 
        275                 280                 285             


Lys Gln Gln Arg Ile Lys Met Leu Ile Leu Pro Pro Val Pro Val Pro 
    290                 295                 300                 


Lys Ile Lys Gly Ile Asp Pro Asp Leu Leu Lys Glu Gly Lys Leu Glu 
305                 310                 315                 320 


Glu Val Asn Thr Ile Leu Ala Ile His Asp Ser Tyr Lys Pro Glu Phe 
                325                 330                 335     


His Ser Asp Asp Ser Trp Val Glu Phe Ile Glu Leu Asp Ile Asp Glu 
            340                 345                 350         


Pro Asp Glu Lys Thr Glu Glu Ser Asp Thr Asp Arg Leu Leu Ser Ser 
        355                 360                 365             


Asp His Glu Lys Ser His Ser Asn Leu Gly Val Lys Asp Gly Asp Ser 
    370                 375                 380                 


Gly Arg Thr Ser Cys Cys Glu Pro Asp Ile Leu Glu Thr Asp Phe Asn 
385                 390                 395                 400 


Ala Asn Asp Ile His Glu Gly Thr Ser Glu Val Ala Gln Pro Gln Arg 
                405                 410                 415     


Leu Lys Gly Glu Ala Asp Leu Leu Cys Leu Asp Gln Lys Asn Gln Asn 
            420                 425                 430         


Asn Ser Pro Tyr His Asp Ala Cys Pro Ala Thr Gln Gln Pro Ser Val 
        435                 440                 445             


Ile Gln Ala Glu Lys Asn Lys Pro Gln Pro Leu Pro Thr Glu Gly Ala 
    450                 455                 460                 


Glu Ser Thr His Gln Ala Ala His Ile Gln Leu Ser Asn Pro Ser Ser 
465                 470                 475                 480 


Leu Ser Asn Ile Asp Phe Tyr Ala Gln Val Ser Asp Ile Thr Pro Ala 
                485                 490                 495     


Gly Ser Val Val Leu Ser Pro Gly Gln Lys Asn Lys Ala Gly Met Ser 
            500                 505                 510         


Gln Cys Asp Met His Pro Glu Met Val Ser Leu Cys Gln Glu Asn Phe 
        515                 520                 525             


Leu Met Asp Asn Ala Tyr Phe Cys Glu Ala Asp Ala Lys Lys Cys Ile 
    530                 535                 540                 


Pro Val Ala Pro His Ile Lys Val Glu Ser His Ile Gln Pro Ser Leu 
545                 550                 555                 560 


Asn Gln Glu Asp Ile Tyr Ile Thr Thr Glu Ser Leu Thr Thr Ala Ala 
                565                 570                 575     


Gly Arg Pro Gly Thr Gly Glu His Val Pro Gly Ser Glu Met Pro Val 
            580                 585                 590         


Pro Asp Tyr Thr Ser Ile His Ile Val Gln Ser Pro Gln Gly Leu Ile 
        595                 600                 605             


Leu Asn Ala Thr Ala Leu Pro Leu Pro Asp Lys Glu Phe Leu Ser Ser 
    610                 615                 620                 


Cys Gly Tyr Val Ser Thr Asp Gln Leu Asn Lys Ile Met Pro 
625                 630                 635             


<210>  50
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Thr Thr Ser Pro Ile Leu Gln Leu Leu Leu Arg Leu Ser Leu Cys 
1               5                   10                  15      


Gly Leu Leu Leu Gln Arg Ala Glu Thr Gly Ser Lys Gly Gln Thr Ala 
            20                  25                  30          


Gly Glu Leu Tyr Gln Arg Trp Glu Arg Tyr Arg Arg Glu Cys Gln Glu 
        35                  40                  45              


Thr Leu Ala Ala Ala Glu Pro Pro Ser Gly Leu Ala Cys Asn Gly Ser 
    50                  55                  60                  


Phe Asp Met Tyr Val Cys Trp Asp Tyr Ala Ala Pro Asn Ala Thr Ala 
65                  70                  75                  80  


Arg Ala Ser Cys Pro Trp Tyr Leu Pro Trp His His His Val Ala Ala 
                85                  90                  95      


Gly Phe Val Leu Arg Gln Cys Gly Ser Asp Gly Gln Trp Gly Leu Trp 
            100                 105                 110         


Arg Asp His Thr Gln Cys Glu Asn Pro Glu Lys Asn Glu Ala Phe Leu 
        115                 120                 125             


Asp Gln Arg Leu Ile Leu Glu Arg Leu Gln Val Met Tyr Thr Val Gly 
    130                 135                 140                 


Tyr Ser Leu Ser Leu Ala Thr Leu Leu Leu Ala Leu Leu Ile Leu Ser 
145                 150                 155                 160 


Leu Phe Arg Arg Leu His Cys Thr Arg Asn Tyr Ile His Ile Asn Leu 
                165                 170                 175     


Phe Thr Ser Phe Met Leu Arg Ala Ala Ala Ile Leu Ser Arg Asp Arg 
            180                 185                 190         


Leu Leu Pro Arg Pro Gly Pro Tyr Leu Gly Asp Gln Ala Leu Ala Leu 
        195                 200                 205             


Trp Asn Gln Ala Leu Ala Ala Cys Arg Thr Ala Gln Ile Val Thr Gln 
    210                 215                 220                 


Tyr Cys Val Gly Ala Asn Tyr Thr Trp Leu Leu Val Glu Gly Val Tyr 
225                 230                 235                 240 


Leu His Ser Leu Leu Val Leu Val Gly Gly Ser Glu Glu Gly His Phe 
                245                 250                 255     


Arg Tyr Tyr Leu Leu Leu Gly Trp Gly Ala Pro Ala Leu Phe Val Ile 
            260                 265                 270         


Pro Trp Val Ile Val Arg Tyr Leu Tyr Glu Asn Thr Gln Cys Trp Glu 
        275                 280                 285             


Arg Asn Glu Val Lys Ala Ile Trp Trp Ile Ile Arg Thr Pro Ile Leu 
    290                 295                 300                 


Met Thr Ile Leu Ile Asn Phe Leu Ile Phe Ile Arg Ile Leu Gly Ile 
305                 310                 315                 320 


Leu Leu Ser Lys Leu Arg Thr Arg Gln Met Arg Cys Arg Asp Tyr Arg 
                325                 330                 335     


Leu Arg Leu Ala Arg Ser Thr Leu Thr Leu Val Pro Leu Leu Gly Val 
            340                 345                 350         


His Glu Val Val Phe Ala Pro Val Thr Glu Glu Gln Ala Arg Gly Ala 
        355                 360                 365             


Leu Arg Phe Ala Lys Leu Gly Phe Glu Ile Phe Leu Ser Ser Phe Gln 
    370                 375                 380                 


Gly Phe Leu Val Ser Val Leu Tyr Cys Phe Ile Asn Lys Glu Val Gln 
385                 390                 395                 400 


Ser Glu Ile Arg Arg Gly Trp His His Cys Arg Leu Arg Arg Ser Leu 
                405                 410                 415     


Gly Glu Glu Gln Arg Gln Leu Pro Glu Arg Ala Phe Arg Ala Leu Pro 
            420                 425                 430         


Ser Gly Ser Gly Pro Gly Glu Val Pro Thr Ser Arg Gly Leu Ser Ser 
        435                 440                 445             


Gly Thr Leu Pro Gly Pro Gly Asn Glu Ala Ser Arg Glu Leu Glu Ser 
    450                 455                 460                 


Tyr Cys 
465     


<210>  51
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Gly Asp Trp Ser Ala Leu Gly Lys Leu Leu Asp Lys Val Gln Ala 
1               5                   10                  15      


Tyr Ser Thr Ala Gly Gly Lys Val Trp Leu Ser Val Leu Phe Ile Phe 
            20                  25                  30          


Arg Ile Leu Leu Leu Gly Thr Ala Val Glu Ser Ala Trp Gly Asp Glu 
        35                  40                  45              


Gln Ser Ala Phe Arg Cys Asn Thr Gln Gln Pro Gly Cys Glu Asn Val 
    50                  55                  60                  


Cys Tyr Asp Lys Ser Phe Pro Ile Ser His Val Arg Phe Trp Val Leu 
65                  70                  75                  80  


Gln Ile Ile Phe Val Ser Val Pro Thr Leu Leu Tyr Leu Ala His Val 
                85                  90                  95      


Phe Tyr Val Met Arg Lys Glu Glu Lys Leu Asn Lys Lys Glu Glu Glu 
            100                 105                 110         


Leu Lys Val Ala Gln Thr Asp Gly Val Asn Val Asp Met His Leu Lys 
        115                 120                 125             


Gln Ile Glu Ile Lys Lys Phe Lys Tyr Gly Ile Glu Glu His Gly Lys 
    130                 135                 140                 


Val Lys Met Arg Gly Gly Leu Leu Arg Thr Tyr Ile Ile Ser Ile Leu 
145                 150                 155                 160 


Phe Lys Ser Ile Phe Glu Val Ala Phe Leu Leu Ile Gln Trp Tyr Ile 
                165                 170                 175     


Tyr Gly Phe Ser Leu Ser Ala Val Tyr Thr Cys Lys Arg Asp Pro Cys 
            180                 185                 190         


Pro His Gln Val Asp Cys Phe Leu Ser Arg Pro Thr Glu Lys Thr Ile 
        195                 200                 205             


Phe Ile Ile Phe Met Leu Val Val Ser Leu Val Ser Leu Ala Leu Asn 
    210                 215                 220                 


Ile Ile Glu Leu Phe Tyr Val Phe Phe Lys Gly Val Lys Asp Arg Val 
225                 230                 235                 240 


Lys Gly Lys Ser Asp Pro Tyr His Ala Thr Ser Gly Ala Leu Ser Pro 
                245                 250                 255     


Ala Lys Asp Cys Gly Ser Gln Lys Tyr Ala Tyr Phe Asn Gly Cys Ser 
            260                 265                 270         


Ser Pro Thr Ala Pro Leu Ser Pro Met Ser Pro Pro Gly Tyr Lys Leu 
        275                 280                 285             


Val Thr Gly Asp Arg Asn Asn Ser Ser Cys Arg Asn Tyr Asn Lys Gln 
    290                 295                 300                 


Ala Ser Glu Gln Asn Trp Ala Asn Tyr Ser Ala Glu Gln Asn Arg Met 
305                 310                 315                 320 


Gly Gln Ala Gly Ser Thr Ile Ser Asn Ser His Ala Gln Pro Phe Asp 
                325                 330                 335     


Phe Pro Asp Asp Asn Gln Asn Ser Lys Lys Leu Ala Ala Gly His Glu 
            340                 345                 350         


Leu Gln Pro Leu Ala Ile Val Asp Gln Arg Pro Ser Ser Arg Ala Ser 
        355                 360                 365             


Ser Arg Ala Ser Ser Arg Pro Arg Pro Asp Asp Leu Glu Ile 
    370                 375                 380         


<210>  52
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Asn Trp Thr Gly Leu Tyr Thr Leu Leu Ser Gly Val Asn Arg His 
1               5                   10                  15      


Ser Thr Ala Ile Gly Arg Val Trp Leu Ser Val Ile Phe Ile Phe Arg 
            20                  25                  30          


Ile Met Val Leu Val Val Ala Ala Glu Ser Val Trp Gly Asp Glu Lys 
        35                  40                  45              


Ser Ser Phe Ile Cys Asn Thr Leu Gln Pro Gly Cys Asn Ser Val Cys 
    50                  55                  60                  


Tyr Asp Gln Phe Phe Pro Ile Ser His Val Arg Leu Trp Ser Leu Gln 
65                  70                  75                  80  


Leu Ile Leu Val Ser Thr Pro Ala Leu Leu Val Ala Met His Val Ala 
                85                  90                  95      


His Gln Gln His Ile Glu Lys Lys Met Leu Arg Leu Glu Gly His Gly 
            100                 105                 110         


Asp Pro Leu His Leu Glu Glu Val Lys Arg His Lys Val His Ile Ser 
        115                 120                 125             


Gly Thr Leu Trp Trp Thr Tyr Val Ile Ser Val Val Phe Arg Leu Leu 
    130                 135                 140                 


Phe Glu Ala Val Phe Met Tyr Val Phe Tyr Leu Leu Tyr Pro Gly Tyr 
145                 150                 155                 160 


Ala Met Val Arg Leu Val Lys Cys Asp Val Tyr Pro Cys Pro Asn Thr 
                165                 170                 175     


Val Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr Val Phe Thr Val 
            180                 185                 190         


Phe Met Leu Ala Ala Ser Gly Ile Cys Ile Ile Leu Asn Val Ala Glu 
        195                 200                 205             


Val Val Tyr Leu Ile Ile Arg Ala Cys Ala Arg Arg Ala Gln Arg Arg 
    210                 215                 220                 


Ser Asn Pro Pro Ser Arg Lys Gly Ser Gly Phe Gly His Arg Leu Ser 
225                 230                 235                 240 


Pro Glu Tyr Lys Gln Asn Glu Ile Asn Lys Leu Leu Ser Glu Gln Asp 
                245                 250                 255     


Gly Ser Leu Lys Asp Ile Leu Arg Arg Ser Pro Gly Thr Gly Ala Gly 
            260                 265                 270         


Leu Ala Glu Lys Ser Asp Arg Cys Ser Ala Cys 
        275                 280             


<210>  53
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Tyr Ser Phe Asn Thr Leu Arg Leu Tyr Leu Trp Glu Thr Ile Val 
1               5                   10                  15      


Phe Phe Ser Leu Ala Ala Ser Lys Glu Ala Glu Ala Ala Arg Ser Ala 
            20                  25                  30          


Pro Lys Pro Met Ser Pro Ser Asp Phe Leu Asp Lys Leu Met Gly Arg 
        35                  40                  45              


Thr Ser Gly Tyr Asp Ala Arg Ile Arg Pro Asn Phe Lys Gly Pro Pro 
    50                  55                  60                  


Val Asn Val Ser Cys Asn Ile Phe Ile Asn Ser Phe Gly Ser Ile Ala 
65                  70                  75                  80  


Glu Thr Thr Met Asp Tyr Arg Val Asn Ile Phe Leu Arg Gln Gln Trp 
                85                  90                  95      


Asn Asp Pro Arg Leu Ala Tyr Asn Glu Tyr Pro Asp Asp Ser Leu Asp 
            100                 105                 110         


Leu Asp Pro Ser Met Leu Asp Ser Ile Trp Lys Pro Asp Leu Phe Phe 
        115                 120                 125             


Ala Asn Glu Lys Gly Ala His Phe His Glu Ile Thr Thr Asp Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Ser Arg Asn Gly Asn Val Leu Tyr Ser Ile Arg Ile 
145                 150                 155                 160 


Thr Leu Thr Leu Ala Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
                165                 170                 175     


Val Gln Thr Cys Ile Met Gln Leu Glu Ser Phe Gly Tyr Thr Met Asn 
            180                 185                 190         


Asp Leu Ile Phe Glu Trp Gln Glu Gln Gly Ala Val Gln Val Ala Asp 
        195                 200                 205             


Gly Leu Thr Leu Pro Gln Phe Ile Leu Lys Glu Glu Lys Asp Leu Arg 
    210                 215                 220                 


Tyr Cys Thr Lys His Tyr Asn Thr Gly Lys Phe Thr Cys Ile Glu Ala 
225                 230                 235                 240 


Arg Phe His Leu Glu Arg Gln Met Gly Tyr Tyr Leu Ile Gln Met Tyr 
                245                 250                 255     


Ile Pro Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile 
            260                 265                 270         


Asn Met Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val 
        275                 280                 285             


Leu Thr Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys 
    290                 295                 300                 


Val Ser Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu 
305                 310                 315                 320 


Phe Val Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser 
                325                 330                 335     


Arg Gln His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His 
            340                 345                 350         


Lys Glu Asp Glu Ala Gly Glu Gly Arg Phe Asn Phe Ser Ala Tyr Gly 
        355                 360                 365             


Met Gly Pro Ala Cys Leu Gln Ala Lys Asp Gly Ile Ser Val Lys Gly 
    370                 375                 380                 


Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro Pro Ala Pro Ser Lys Ser 
385                 390                 395                 400 


Pro Glu Glu Met Arg Lys Leu Phe Ile Gln Arg Ala Lys Lys Ile Asp 
                405                 410                 415     


Lys Ile Ser Arg Ile Gly Phe Pro Met Ala Phe Leu Ile Phe Asn Met 
            420                 425                 430         


Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg Arg Glu Asp Val His Asn 
        435                 440                 445             


Gln 
    


<210>  54
<211>  652
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Pro Leu Leu Leu Leu Leu Leu Leu Leu Pro Ser Pro Leu His Pro 
1               5                   10                  15      


His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
            20                  25                  30          


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
        35                  40                  45              


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
    50                  55                  60                  


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
65                  70                  75                  80  


Cys Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
                85                  90                  95      


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
            100                 105                 110         


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
        115                 120                 125             


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
    130                 135                 140                 


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
145                 150                 155                 160 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
                165                 170                 175     


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
            180                 185                 190         


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
        195                 200                 205             


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
    210                 215                 220                 


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
225                 230                 235                 240 


Glu Asn Val Tyr Val Trp Lys Gln Gly Val Asp Val Lys Ala Met Thr 
                245                 250                 255     


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
            260                 265                 270         


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
        275                 280                 285             


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
    290                 295                 300                 


Val Arg Ala Thr Arg Thr Val Val Lys Phe Pro Thr Lys Ala His Thr 
305                 310                 315                 320 


Thr Pro Trp Gly Leu Phe Tyr Ser Trp Ser Thr Ala Ser Leu Asp Ser 
                325                 330                 335     


Gln Met Pro Ser Ser Leu His Pro Thr Gln Glu Ser Thr Lys Glu Gln 
            340                 345                 350         


Thr Thr Phe Pro Pro Arg Trp Thr Pro Asn Phe Thr Leu His Met Glu 
        355                 360                 365             


Ser Ile Thr Phe Ser Lys Thr Pro Lys Ser Thr Thr Glu Pro Thr Pro 
    370                 375                 380                 


Ser Pro Thr Thr Ser Glu Pro Val Pro Glu Pro Ala Pro Asn Met Thr 
385                 390                 395                 400 


Thr Leu Glu Pro Thr Pro Ser Pro Thr Thr Pro Glu Pro Thr Ser Glu 
                405                 410                 415     


Pro Ala Pro Ser Pro Thr Thr Pro Glu Pro Thr Ser Glu Pro Ala Pro 
            420                 425                 430         


Ser Pro Thr Thr Pro Glu Pro Thr Ser Glu Pro Ala Pro Ser Pro Thr 
        435                 440                 445             


Thr Pro Glu Pro Thr Pro Ile Pro Thr Ile Ala Thr Ser Pro Thr Ile 
    450                 455                 460                 


Leu Val Ser Ala Thr Ser Leu Ile Thr Pro Lys Ser Thr Phe Leu Thr 
465                 470                 475                 480 


Thr Thr Lys Pro Val Ser Leu Leu Glu Ser Thr Lys Lys Thr Ile Pro 
                485                 490                 495     


Glu Leu Asp Gln Pro Pro Lys Leu Arg Gly Val Leu Gln Gly His Leu 
            500                 505                 510         


Glu Ser Ser Arg Asn Asp Pro Phe Leu His Pro Asp Phe Cys Cys Leu 
        515                 520                 525             


Leu Pro Leu Gly Phe Tyr Val Leu Gly Leu Phe Trp Leu Leu Phe Ala 
    530                 535                 540                 


Ser Val Val Leu Ile Leu Leu Leu Ser Trp Val Gly His Val Lys Pro 
545                 550                 555                 560 


Gln Ala Leu Asp Ser Gly Gln Gly Ala Ala Leu Thr Thr Ala Thr Gln 
                565                 570                 575     


Thr Thr His Leu Glu Leu Gln Arg Gly Arg Gln Val Thr Val Pro Arg 
            580                 585                 590         


Ala Trp Leu Leu Phe Leu Arg Gly Ser Leu Pro Thr Phe Arg Ser Ser 
        595                 600                 605             


Leu Phe Leu Trp Val Arg Pro Asn Gly Arg Val Gly Pro Leu Val Ala 
    610                 615                 620                 


Gly Arg Arg Pro Ser Ala Leu Ser Gln Gly Arg Gly Gln Asp Leu Leu 
625                 630                 635                 640 


Ser Thr Val Ser Ile Arg Tyr Ser Gly His Ser Leu 
                645                 650         


<210>  55
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Pro Ala Trp Gly Ala Leu Phe Leu Leu Trp Ala Thr Ala Glu Ala 
1               5                   10                  15      


Thr Lys Asp Cys Pro Ser Pro Cys Thr Cys Arg Ala Leu Glu Thr Met 
            20                  25                  30          


Gly Leu Trp Val Asp Cys Arg Gly His Gly Leu Thr Ala Leu Pro Ala 
        35                  40                  45              


Leu Pro Ala Arg Thr Arg His Leu Leu Leu Ala Asn Asn Ser Leu Gln 
    50                  55                  60                  


Ser Val Pro Pro Gly Ala Phe Asp His Leu Pro Gln Leu Gln Thr Leu 
65                  70                  75                  80  


Asp Val Thr Gln Asn Pro Trp His Cys Asp Cys Ser Leu Thr Tyr Leu 
                85                  90                  95      


Arg Leu Trp Leu Glu Asp Arg Thr Pro Glu Ala Leu Leu Gln Val Arg 
            100                 105                 110         


Cys Ala Ser Pro Ser Leu Ala Ala His Gly Pro Leu Gly Arg Leu Thr 
        115                 120                 125             


Gly Tyr Gln Leu Gly Ser Cys Gly Trp Gln Leu Gln Ala Ser Trp Val 
    130                 135                 140                 


Arg Pro Gly Val Leu Trp Asp Val Ala Leu Val Ala Val Ala Ala Leu 
145                 150                 155                 160 


Gly Leu Ala Leu Leu Ala Gly Leu Leu Cys Ala Thr Thr Glu Ala Leu 
                165                 170                 175     


Asp 
    


<210>  56
<211>  1103
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Thr Ala Cys Ala Arg Arg Ala Gly Gly Leu Pro Asp Pro Gly Leu 
1               5                   10                  15      


Cys Gly Pro Ala Trp Trp Ala Pro Ser Leu Pro Arg Leu Pro Arg Ala 
            20                  25                  30          


Leu Pro Arg Leu Pro Leu Leu Leu Leu Leu Leu Leu Leu Gln Pro Pro 
        35                  40                  45              


Ala Leu Ser Ala Val Phe Thr Val Gly Val Leu Gly Pro Trp Ala Cys 
    50                  55                  60                  


Asp Pro Ile Phe Ser Arg Ala Arg Pro Asp Leu Ala Ala Arg Leu Ala 
65                  70                  75                  80  


Ala Ala Arg Leu Asn Arg Asp Pro Gly Leu Ala Gly Gly Pro Arg Phe 
                85                  90                  95      


Glu Val Ala Leu Leu Pro Glu Pro Cys Arg Thr Pro Gly Ser Leu Gly 
            100                 105                 110         


Ala Val Ser Ser Ala Leu Ala Arg Val Ser Gly Leu Val Gly Pro Val 
        115                 120                 125             


Asn Pro Ala Ala Cys Arg Pro Ala Glu Leu Leu Ala Glu Glu Ala Gly 
    130                 135                 140                 


Ile Ala Leu Val Pro Trp Gly Cys Pro Trp Thr Gln Ala Glu Gly Thr 
145                 150                 155                 160 


Thr Ala Pro Ala Val Thr Pro Ala Ala Asp Ala Leu Tyr Ala Leu Leu 
                165                 170                 175     


Arg Ala Phe Gly Trp Ala Arg Val Ala Leu Val Thr Ala Pro Gln Asp 
            180                 185                 190         


Leu Trp Val Glu Ala Gly Arg Ser Leu Ser Thr Ala Leu Arg Ala Arg 
        195                 200                 205             


Gly Leu Pro Val Ala Ser Val Thr Ser Met Glu Pro Leu Asp Leu Ser 
    210                 215                 220                 


Gly Ala Arg Glu Ala Leu Arg Lys Val Arg Asp Gly Pro Arg Val Thr 
225                 230                 235                 240 


Ala Val Ile Met Val Met His Ser Val Leu Leu Gly Gly Glu Glu Gln 
                245                 250                 255     


Arg Tyr Leu Leu Glu Ala Ala Glu Glu Leu Gly Leu Thr Asp Gly Ser 
            260                 265                 270         


Leu Val Phe Leu Pro Phe Asp Thr Ile His Tyr Ala Leu Ser Pro Gly 
        275                 280                 285             


Pro Glu Ala Leu Ala Ala Leu Ala Asn Ser Ser Gln Leu Arg Arg Ala 
    290                 295                 300                 


His Asp Ala Val Leu Thr Leu Thr Arg His Cys Pro Ser Glu Gly Ser 
305                 310                 315                 320 


Val Leu Asp Ser Leu Arg Arg Ala Gln Glu Arg Arg Glu Leu Pro Ser 
                325                 330                 335     


Asp Leu Asn Leu Gln Gln Val Ser Pro Leu Phe Gly Thr Ile Tyr Asp 
            340                 345                 350         


Ala Val Phe Leu Leu Ala Arg Gly Val Ala Glu Ala Arg Ala Ala Ala 
        355                 360                 365             


Gly Gly Arg Trp Val Ser Gly Ala Ala Val Ala Arg His Ile Arg Asp 
    370                 375                 380                 


Ala Gln Val Pro Gly Phe Cys Gly Asp Leu Gly Gly Asp Glu Glu Pro 
385                 390                 395                 400 


Pro Phe Val Leu Leu Asp Thr Asp Ala Ala Gly Asp Arg Leu Phe Ala 
                405                 410                 415     


Thr Tyr Met Leu Asp Pro Ala Arg Gly Ser Phe Leu Ser Ala Gly Thr 
            420                 425                 430         


Arg Met His Phe Pro Arg Gly Gly Ser Ala Pro Gly Pro Asp Pro Ser 
        435                 440                 445             


Cys Trp Phe Asp Pro Asn Asn Ile Cys Gly Gly Gly Leu Glu Pro Gly 
    450                 455                 460                 


Leu Val Phe Leu Gly Phe Leu Leu Val Val Gly Met Gly Leu Ala Gly 
465                 470                 475                 480 


Ala Phe Leu Ala His Tyr Val Arg His Arg Leu Leu His Met Gln Met 
                485                 490                 495     


Val Ser Gly Pro Asn Lys Ile Ile Leu Thr Val Asp Asp Ile Thr Phe 
            500                 505                 510         


Leu His Pro His Gly Gly Thr Ser Arg Lys Val Ala Gln Gly Ser Arg 
        515                 520                 525             


Ser Ser Leu Gly Ala Arg Ser Met Ser Asp Ile Arg Ser Gly Pro Ser 
    530                 535                 540                 


Gln His Leu Asp Ser Pro Asn Ile Gly Val Tyr Glu Gly Asp Arg Val 
545                 550                 555                 560 


Trp Leu Lys Lys Phe Pro Gly Asp Gln His Ile Ala Ile Arg Pro Ala 
                565                 570                 575     


Thr Lys Thr Ala Phe Ser Lys Leu Gln Glu Leu Arg His Glu Asn Val 
            580                 585                 590         


Ala Leu Tyr Leu Gly Leu Phe Leu Ala Arg Gly Ala Glu Gly Pro Ala 
        595                 600                 605             


Ala Leu Trp Glu Gly Asn Leu Ala Val Val Ser Glu His Cys Thr Arg 
    610                 615                 620                 


Gly Ser Leu Gln Asp Leu Leu Ala Gln Arg Glu Ile Lys Leu Asp Trp 
625                 630                 635                 640 


Met Phe Lys Ser Ser Leu Leu Leu Asp Leu Ile Lys Gly Ile Arg Tyr 
                645                 650                 655     


Leu His His Arg Gly Val Ala His Gly Arg Leu Lys Ser Arg Asn Cys 
            660                 665                 670         


Ile Val Asp Gly Arg Phe Val Leu Lys Ile Thr Asp His Gly His Gly 
        675                 680                 685             


Arg Leu Leu Glu Ala Gln Lys Val Leu Pro Glu Pro Pro Arg Ala Glu 
    690                 695                 700                 


Asp Gln Leu Trp Thr Ala Pro Glu Leu Leu Arg Asp Pro Ala Leu Glu 
705                 710                 715                 720 


Arg Arg Gly Thr Leu Ala Gly Asp Val Phe Ser Leu Ala Ile Ile Met 
                725                 730                 735     


Gln Glu Val Val Cys Arg Ser Ala Pro Tyr Ala Met Leu Glu Leu Thr 
            740                 745                 750         


Pro Glu Glu Val Val Gln Arg Val Arg Ser Pro Pro Pro Leu Cys Arg 
        755                 760                 765             


Pro Leu Val Ser Met Asp Gln Ala Pro Val Glu Cys Ile Leu Leu Met 
    770                 775                 780                 


Lys Gln Cys Trp Ala Glu Gln Pro Glu Leu Arg Pro Ser Met Asp His 
785                 790                 795                 800 


Thr Phe Asp Leu Phe Lys Asn Ile Asn Lys Gly Arg Lys Thr Asn Ile 
                805                 810                 815     


Ile Asp Ser Met Leu Arg Met Leu Glu Gln Tyr Ser Ser Asn Leu Glu 
            820                 825                 830         


Asp Leu Ile Arg Glu Arg Thr Glu Glu Leu Glu Leu Glu Lys Gln Lys 
        835                 840                 845             


Thr Asp Arg Leu Leu Thr Gln Met Leu Pro Pro Ser Val Ala Glu Ala 
    850                 855                 860                 


Leu Lys Thr Gly Thr Pro Val Glu Pro Glu Tyr Phe Glu Gln Val Thr 
865                 870                 875                 880 


Leu Tyr Phe Ser Asp Ile Val Gly Phe Thr Thr Ile Ser Ala Met Ser 
                885                 890                 895     


Glu Pro Ile Glu Val Val Asp Leu Leu Asn Asp Leu Tyr Thr Leu Phe 
            900                 905                 910         


Asp Ala Ile Ile Gly Ser His Asp Val Tyr Lys Val Glu Thr Ile Gly 
        915                 920                 925             


Asp Ala Tyr Met Val Ala Ser Gly Leu Pro Gln Arg Asn Gly Gln Arg 
    930                 935                 940                 


His Ala Ala Glu Ile Ala Asn Met Ser Leu Asp Ile Leu Ser Ala Val 
945                 950                 955                 960 


Gly Thr Phe Arg Met Arg His Met Pro Glu Val Pro Val Arg Ile Arg 
                965                 970                 975     


Ile Gly Leu His Ser Gly Pro Cys Val Ala Gly Val Val Gly Leu Thr 
            980                 985                 990         


Met Pro Arg Tyr Cys Leu Phe Gly  Asp Thr Val Asn Thr  Ala Ser Arg 
        995                 1000                 1005             


Met Glu  Ser Thr Gly Leu Pro  Tyr Arg Ile His Val  Asn Leu Ser 
    1010                 1015                 1020             


Thr Val  Gly Ile Leu Arg Ala  Leu Asp Ser Gly Tyr  Gln Val Glu 
    1025                 1030                 1035             


Leu Arg  Gly Arg Thr Glu Leu  Lys Gly Lys Gly Ala  Glu Asp Thr 
    1040                 1045                 1050             


Phe Trp  Leu Val Gly Arg Arg  Gly Phe Asn Lys Pro  Ile Pro Lys 
    1055                 1060                 1065             


Pro Pro  Asp Leu Gln Pro Gly  Ser Ser Asn His Gly  Ile Ser Leu 
    1070                 1075                 1080             


Gln Glu  Ile Pro Pro Glu Arg  Arg Arg Lys Leu Glu  Lys Ala Arg 
    1085                 1090                 1095             


Pro Gly  Gln Phe Ser 
    1100             


<210>  57
<211>  651
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Ala Arg Gly Ser Ala Val Ala Trp Ala Ala Leu Gly Pro Leu Leu 
1               5                   10                  15      


Trp Gly Cys Ala Leu Gly Leu Gln Gly Gly Met Leu Tyr Pro Gln Glu 
            20                  25                  30          


Ser Pro Ser Arg Glu Cys Lys Glu Leu Asp Gly Leu Trp Ser Phe Arg 
        35                  40                  45              


Ala Asp Phe Ser Asp Asn Arg Arg Arg Gly Phe Glu Glu Gln Trp Tyr 
    50                  55                  60                  


Arg Arg Pro Leu Trp Glu Ser Gly Pro Thr Val Asp Met Pro Val Pro 
65                  70                  75                  80  


Ser Ser Phe Asn Asp Ile Ser Gln Asp Trp Arg Leu Arg His Phe Val 
                85                  90                  95      


Gly Trp Val Trp Tyr Glu Arg Glu Val Ile Leu Pro Glu Arg Trp Thr 
            100                 105                 110         


Gln Asp Leu Arg Thr Arg Val Val Leu Arg Ile Gly Ser Ala His Ser 
        115                 120                 125             


Tyr Ala Ile Val Trp Val Asn Gly Val Asp Thr Leu Glu His Glu Gly 
    130                 135                 140                 


Gly Tyr Leu Pro Phe Glu Ala Asp Ile Ser Asn Leu Val Gln Val Gly 
145                 150                 155                 160 


Pro Leu Pro Ser Arg Leu Arg Ile Thr Ile Ala Ile Asn Asn Thr Leu 
                165                 170                 175     


Thr Pro Thr Thr Leu Pro Pro Gly Thr Ile Gln Tyr Leu Thr Asp Thr 
            180                 185                 190         


Ser Lys Tyr Pro Lys Gly Tyr Phe Val Gln Asn Thr Tyr Phe Asp Phe 
        195                 200                 205             


Phe Asn Tyr Ala Gly Leu Gln Arg Ser Val Leu Leu Tyr Thr Thr Pro 
    210                 215                 220                 


Thr Thr Tyr Ile Asp Asp Ile Thr Val Thr Thr Ser Val Glu Gln Asp 
225                 230                 235                 240 


Ser Gly Leu Val Asn Tyr Gln Ile Ser Val Lys Gly Ser Asn Leu Phe 
                245                 250                 255     


Lys Leu Glu Val Arg Leu Leu Asp Ala Glu Asn Lys Val Val Ala Asn 
            260                 265                 270         


Gly Thr Gly Thr Gln Gly Gln Leu Lys Val Pro Gly Val Ser Leu Trp 
        275                 280                 285             


Trp Pro Tyr Leu Met His Glu Arg Pro Ala Tyr Leu Tyr Ser Leu Glu 
    290                 295                 300                 


Val Gln Leu Thr Ala Gln Thr Ser Leu Gly Pro Val Ser Asp Phe Tyr 
305                 310                 315                 320 


Thr Leu Pro Val Gly Ile Arg Thr Val Ala Val Thr Lys Ser Gln Phe 
                325                 330                 335     


Leu Ile Asn Gly Lys Pro Phe Tyr Phe His Gly Val Asn Lys His Glu 
            340                 345                 350         


Asp Ala Asp Ile Arg Gly Lys Gly Phe Asp Trp Pro Leu Leu Val Lys 
        355                 360                 365             


Asp Phe Asn Leu Leu Arg Trp Leu Gly Ala Asn Ala Phe Arg Thr Ser 
    370                 375                 380                 


His Tyr Pro Tyr Ala Glu Glu Val Met Gln Met Cys Asp Arg Tyr Gly 
385                 390                 395                 400 


Ile Val Val Ile Asp Glu Cys Pro Gly Val Gly Leu Ala Leu Pro Gln 
                405                 410                 415     


Phe Phe Asn Asn Val Ser Leu His His His Met Gln Val Met Glu Glu 
            420                 425                 430         


Val Val Arg Arg Asp Lys Asn His Pro Ala Val Val Met Trp Ser Val 
        435                 440                 445             


Ala Asn Glu Pro Ala Ser His Leu Glu Ser Ala Gly Tyr Tyr Leu Lys 
    450                 455                 460                 


Met Val Ile Ala His Thr Lys Ser Leu Asp Pro Ser Arg Pro Val Thr 
465                 470                 475                 480 


Phe Val Ser Asn Ser Asn Tyr Ala Ala Asp Lys Gly Ala Pro Tyr Val 
                485                 490                 495     


Asp Val Ile Cys Leu Asn Ser Tyr Tyr Ser Trp Tyr His Asp Tyr Gly 
            500                 505                 510         


His Leu Glu Leu Ile Gln Leu Gln Leu Ala Thr Gln Phe Glu Asn Trp 
        515                 520                 525             


Tyr Lys Lys Tyr Gln Lys Pro Ile Ile Gln Ser Glu Tyr Gly Ala Glu 
    530                 535                 540                 


Thr Ile Ala Gly Phe His Gln Asp Pro Pro Leu Met Phe Thr Glu Glu 
545                 550                 555                 560 


Tyr Gln Lys Ser Leu Leu Glu Gln Tyr His Leu Gly Leu Asp Gln Lys 
                565                 570                 575     


Arg Arg Lys Tyr Val Val Gly Glu Leu Ile Trp Asn Phe Ala Asp Phe 
            580                 585                 590         


Met Thr Glu Gln Ser Pro Thr Arg Val Leu Gly Asn Lys Lys Gly Ile 
        595                 600                 605             


Phe Thr Arg Gln Arg Gln Pro Lys Ser Ala Ala Phe Leu Leu Arg Glu 
    610                 615                 620                 


Arg Tyr Trp Lys Ile Ala Asn Glu Thr Arg Tyr Pro His Ser Val Ala 
625                 630                 635                 640 


Lys Ser Gln Cys Leu Glu Asn Ser Leu Phe Thr 
                645                 650     


<210>  58
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Gly Pro Gly Arg Gly Phe Gly Lys 
            20                  25                  30          


Arg Arg His Pro Lys Lys Leu Thr Pro Leu Ala Tyr Lys Gln Phe Ile 
        35                  40                  45              


Pro Asn Val Ala Glu Lys Thr Leu Gly Ala Ser Gly Arg Tyr Glu Gly 
    50                  55                  60                  


Lys Ile Ser Arg Asn Ser Glu Arg Phe Lys Glu Leu Thr Pro Asn Tyr 
65                  70                  75                  80  


Asn Pro Asp Ile Ile Phe Lys Asp Glu Glu Asn Thr Gly Ala Asp Arg 
                85                  90                  95      


Leu Met Thr Gln Arg Cys Lys Asp Lys Leu Asn Ala Leu Ala Ile Ser 
            100                 105                 110         


Val Met Asn Gln Trp Pro Gly Val Lys Leu Arg Val Thr Glu Gly Trp 
        115                 120                 125             


Asp Glu Asp Gly His His Ser Glu Glu Ser Leu His Tyr Glu Gly Arg 
    130                 135                 140                 


Ala Val Asp Ile Thr Thr Ser Asp Arg Asp Arg Ser Lys Tyr Gly Met 
145                 150                 155                 160 


Leu Ala Arg Leu Ala Val Glu Ala Gly Phe Asp Trp Val Tyr Tyr Glu 
                165                 170                 175     


Ser Lys Ala His Ile His Cys Ser Val Lys Ala Glu Asn Ser Val Ala 
            180                 185                 190         


Ala Lys Ser Gly Gly Cys Phe Pro Gly Ser Ala Thr Val His Leu Glu 
        195                 200                 205             


Gln Gly Gly Thr Lys Leu Val Lys Asp Leu Ser Pro Gly Asp Arg Val 
    210                 215                 220                 


Leu Ala Ala Asp Asp Gln Gly Arg Leu Leu Tyr Ser Asp Phe Leu Thr 
225                 230                 235                 240 


Phe Leu Asp Arg Asp Asp Gly Ala Lys Lys Val Phe Tyr Val Ile Glu 
                245                 250                 255     


Thr Arg Glu Pro Arg Glu Arg Leu Leu Leu Thr Ala Ala His Leu Leu 
            260                 265                 270         


Phe Val Ala Pro His Asn Asp Ser Ala Thr Gly Glu Pro Glu Ala Ser 
        275                 280                 285             


Ser Gly Ser Gly Pro Pro Ser Gly Gly Ala Leu Gly Pro Arg Ala Leu 
    290                 295                 300                 


Phe Ala Ser Arg Val Arg Pro Gly Gln Arg Val Tyr Val Val Ala Glu 
305                 310                 315                 320 


Arg Asp Gly Asp Arg Arg Leu Leu Pro Ala Ala Val His Ser Val Thr 
                325                 330                 335     


Leu Ser Glu Glu Ala Ala Gly Ala Tyr Ala Pro Leu Thr Ala Gln Gly 
            340                 345                 350         


Thr Ile Leu Ile Asn Arg Val Leu Ala Ser Cys Tyr Ala Val Ile Glu 
        355                 360                 365             


Glu His Ser Trp Ala His Arg Ala Phe Ala Pro Phe Arg Leu Ala His 
    370                 375                 380                 


Ala Leu Leu Ala Ala Leu Ala Pro Ala Arg Thr Asp Arg Gly Gly Asp 
385                 390                 395                 400 


Ser Gly Gly Gly Asp Arg Gly Gly Gly Gly Gly Arg Val Ala Leu Thr 
                405                 410                 415     


Ala Pro Gly Ala Ala Asp Ala Pro Gly Ala Gly Ala Thr Ala Gly Ile 
            420                 425                 430         


His Trp Tyr Ser Gln Leu Leu Tyr Gln Ile Gly Thr Trp Leu Leu Asp 
        435                 440                 445             


Ser Glu Ala Leu His Pro Leu Gly Met Ala Val Lys Ser Ser 
    450                 455                 460         


<210>  59
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Gly Asp Val Leu Glu Gln Phe Phe Ile Leu Thr Gly Leu Leu Val 
1               5                   10                  15      


Cys Leu Ala Cys Leu Ala Lys Cys Val Arg Phe Ser Arg Cys Val Leu 
            20                  25                  30          


Leu Asn Tyr Trp Lys Val Leu Pro Lys Ser Phe Leu Arg Ser Met Gly 
        35                  40                  45              


Gln Trp Ala Val Ile Thr Gly Ala Gly Asp Gly Ile Gly Lys Ala Tyr 
    50                  55                  60                  


Ser Phe Glu Leu Ala Lys Arg Gly Leu Asn Val Val Leu Ile Ser Arg 
65                  70                  75                  80  


Thr Leu Glu Lys Leu Glu Ala Ile Ala Thr Glu Ile Glu Arg Thr Thr 
                85                  90                  95      


Gly Arg Ser Val Lys Ile Ile Gln Ala Asp Phe Thr Lys Asp Asp Ile 
            100                 105                 110         


Tyr Glu His Ile Lys Glu Lys Leu Ala Gly Leu Glu Ile Gly Ile Leu 
        115                 120                 125             


Val Asn Asn Val Gly Met Leu Pro Asn Leu Leu Pro Ser His Phe Leu 
    130                 135                 140                 


Asn Ala Pro Asp Glu Ile Gln Ser Leu Ile His Cys Asn Ile Thr Ser 
145                 150                 155                 160 


Val Val Lys Met Thr Gln Leu Ile Leu Lys His Met Glu Ser Arg Gln 
                165                 170                 175     


Lys Gly Leu Ile Leu Asn Ile Ser Ser Gly Ile Ala Leu Phe Pro Trp 
            180                 185                 190         


Pro Leu Tyr Ser Met Tyr Ser Ala Ser Lys Ala Phe Val Cys Ala Phe 
        195                 200                 205             


Ser Lys Ala Leu Gln Glu Glu Tyr Lys Ala Lys Glu Val Ile Ile Gln 
    210                 215                 220                 


Val Leu Thr Pro Tyr Ala Val Ser Thr Ala Met Thr Lys Tyr Leu Asn 
225                 230                 235                 240 


Thr Asn Val Ile Thr Lys Thr Ala Asp Glu Phe Val Lys Glu Ser Leu 
                245                 250                 255     


Asn Tyr Val Thr Ile Gly Gly Glu Thr Cys Gly Cys Leu Ala His Glu 
            260                 265                 270         


Ile Leu Ala Gly Phe Leu Ser Leu Ile Pro Ala Trp Ala Phe Tyr Ser 
        275                 280                 285             


Gly Ala Phe Gln Arg Leu Leu Leu Thr His Tyr Val Ala Tyr Leu Lys 
    290                 295                 300                 


Leu Asn Thr Lys Val Arg 
305                 310 


<210>  60
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Gly Trp Ser Cys Leu Val Thr Gly Ala Gly Gly Leu Leu Gly Gln 
1               5                   10                  15      


Arg Ile Val Arg Leu Leu Val Glu Glu Lys Glu Leu Lys Glu Ile Arg 
            20                  25                  30          


Ala Leu Asp Lys Ala Phe Arg Pro Glu Leu Arg Glu Glu Phe Ser Lys 
        35                  40                  45              


Leu Gln Asn Arg Thr Lys Leu Thr Val Leu Glu Gly Asp Ile Leu Asp 
    50                  55                  60                  


Glu Pro Phe Leu Lys Arg Ala Cys Gln Asp Val Ser Val Val Ile His 
65                  70                  75                  80  


Thr Ala Cys Ile Ile Asp Val Phe Gly Val Thr His Arg Glu Ser Ile 
                85                  90                  95      


Met Asn Val Asn Val Lys Gly Thr Gln Leu Leu Leu Glu Ala Cys Val 
            100                 105                 110         


Gln Ala Ser Val Pro Val Phe Ile Tyr Thr Ser Ser Ile Glu Val Ala 
        115                 120                 125             


Gly Pro Asn Ser Tyr Lys Glu Ile Ile Gln Asn Gly His Glu Glu Glu 
    130                 135                 140                 


Pro Leu Glu Asn Thr Trp Pro Thr Pro Tyr Pro Tyr Ser Lys Lys Leu 
145                 150                 155                 160 


Ala Glu Lys Ala Val Leu Ala Ala Asn Gly Trp Asn Leu Lys Asn Gly 
                165                 170                 175     


Asp Thr Leu Tyr Thr Cys Ala Leu Arg Pro Thr Tyr Ile Tyr Gly Glu 
            180                 185                 190         


Gly Gly Pro Phe Leu Ser Ala Ser Ile Asn Glu Ala Leu Asn Asn Asn 
        195                 200                 205             


Gly Ile Leu Ser Ser Val Gly Lys Phe Ser Thr Val Asn Pro Val Tyr 
    210                 215                 220                 


Val Gly Asn Val Ala Trp Ala His Ile Leu Ala Leu Arg Ala Leu Arg 
225                 230                 235                 240 


Asp Pro Lys Lys Ala Pro Ser Val Arg Gly Gln Phe Tyr Tyr Ile Ser 
                245                 250                 255     


Asp Asp Thr Pro His Gln Ser Tyr Asp Asn Leu Asn Tyr Ile Leu Ser 
            260                 265                 270         


Lys Glu Phe Gly Leu Arg Leu Asp Ser Arg Trp Ser Leu Pro Leu Thr 
        275                 280                 285             


Leu Met Tyr Trp Ile Gly Phe Leu Leu Glu Val Val Ser Phe Leu Leu 
    290                 295                 300                 


Ser Pro Ile Tyr Ser Tyr Gln Pro Pro Phe Asn Arg His Thr Val Thr 
305                 310                 315                 320 


Leu Ser Asn Ser Val Phe Thr Phe Ser Tyr Lys Lys Ala Gln Arg Asp 
                325                 330                 335     


Leu Ala Tyr Lys Pro Leu Tyr Ser Trp Glu Glu Ala Lys Gln Lys Thr 
            340                 345                 350         


Val Glu Trp Val Gly Ser Leu Val Asp Arg His Lys Glu Thr Leu Lys 
        355                 360                 365             


Ser Lys Thr Gln 
    370         


<210>  61
<211>  1382
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Ala Thr Gly Gly Arg Arg Gly Ala Ala Ala Ala Pro Leu Leu Val 
1               5                   10                  15      


Ala Val Ala Ala Leu Leu Leu Gly Ala Ala Gly His Leu Tyr Pro Gly 
            20                  25                  30          


Glu Val Cys Pro Gly Met Asp Ile Arg Asn Asn Leu Thr Arg Leu His 
        35                  40                  45              


Glu Leu Glu Asn Cys Ser Val Ile Glu Gly His Leu Gln Ile Leu Leu 
    50                  55                  60                  


Met Phe Lys Thr Arg Pro Glu Asp Phe Arg Asp Leu Ser Phe Pro Lys 
65                  70                  75                  80  


Leu Ile Met Ile Thr Asp Tyr Leu Leu Leu Phe Arg Val Tyr Gly Leu 
                85                  90                  95      


Glu Ser Leu Lys Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Ser 
            100                 105                 110         


Arg Leu Phe Phe Asn Tyr Ala Leu Val Ile Phe Glu Met Val His Leu 
        115                 120                 125             


Lys Glu Leu Gly Leu Tyr Asn Leu Met Asn Ile Thr Arg Gly Ser Val 
    130                 135                 140                 


Arg Ile Glu Lys Asn Asn Glu Leu Cys Tyr Leu Ala Thr Ile Asp Trp 
145                 150                 155                 160 


Ser Arg Ile Leu Asp Ser Val Glu Asp Asn Tyr Ile Val Leu Asn Lys 
                165                 170                 175     


Asp Asp Asn Glu Glu Cys Gly Asp Ile Cys Pro Gly Thr Ala Lys Gly 
            180                 185                 190         


Lys Thr Asn Cys Pro Ala Thr Val Ile Asn Gly Gln Phe Val Glu Arg 
        195                 200                 205             


Cys Trp Thr His Ser His Cys Gln Lys Val Cys Pro Thr Ile Cys Lys 
    210                 215                 220                 


Ser His Gly Cys Thr Ala Glu Gly Leu Cys Cys His Ser Glu Cys Leu 
225                 230                 235                 240 


Gly Asn Cys Ser Gln Pro Asp Asp Pro Thr Lys Cys Val Ala Cys Arg 
                245                 250                 255     


Asn Phe Tyr Leu Asp Gly Arg Cys Val Glu Thr Cys Pro Pro Pro Tyr 
            260                 265                 270         


Tyr His Phe Gln Asp Trp Arg Cys Val Asn Phe Ser Phe Cys Gln Asp 
        275                 280                 285             


Leu His His Lys Cys Lys Asn Ser Arg Arg Gln Gly Cys His Gln Tyr 
    290                 295                 300                 


Val Ile His Asn Asn Lys Cys Ile Pro Glu Cys Pro Ser Gly Tyr Thr 
305                 310                 315                 320 


Met Asn Ser Ser Asn Leu Leu Cys Thr Pro Cys Leu Gly Pro Cys Pro 
                325                 330                 335     


Lys Val Cys His Leu Leu Glu Gly Glu Lys Thr Ile Asp Ser Val Thr 
            340                 345                 350         


Ser Ala Gln Glu Leu Arg Gly Cys Thr Val Ile Asn Gly Ser Leu Ile 
        355                 360                 365             


Ile Asn Ile Arg Gly Gly Asn Asn Leu Ala Ala Glu Leu Glu Ala Asn 
    370                 375                 380                 


Leu Gly Leu Ile Glu Glu Ile Ser Gly Tyr Leu Lys Ile Arg Arg Ser 
385                 390                 395                 400 


Tyr Ala Leu Val Ser Leu Ser Phe Phe Arg Lys Leu Arg Leu Ile Arg 
                405                 410                 415     


Gly Glu Thr Leu Glu Ile Gly Asn Tyr Ser Phe Tyr Ala Leu Asp Asn 
            420                 425                 430         


Gln Asn Leu Arg Gln Leu Trp Asp Trp Ser Lys His Asn Leu Thr Ile 
        435                 440                 445             


Thr Gln Gly Lys Leu Phe Phe His Tyr Asn Pro Lys Leu Cys Leu Ser 
    450                 455                 460                 


Glu Ile His Lys Met Glu Glu Val Ser Gly Thr Lys Gly Arg Gln Glu 
465                 470                 475                 480 


Arg Asn Asp Ile Ala Leu Lys Thr Asn Gly Asp Gln Ala Ser Cys Glu 
                485                 490                 495     


Asn Glu Leu Leu Lys Phe Ser Tyr Ile Arg Thr Ser Phe Asp Lys Ile 
            500                 505                 510         


Leu Leu Arg Trp Glu Pro Tyr Trp Pro Pro Asp Phe Arg Asp Leu Leu 
        515                 520                 525             


Gly Phe Met Leu Phe Tyr Lys Glu Ala Pro Tyr Gln Asn Val Thr Glu 
    530                 535                 540                 


Phe Asp Gly Gln Asp Ala Cys Gly Ser Asn Ser Trp Thr Val Val Asp 
545                 550                 555                 560 


Ile Asp Pro Pro Leu Arg Ser Asn Asp Pro Lys Ser Gln Asn His Pro 
                565                 570                 575     


Gly Trp Leu Met Arg Gly Leu Lys Pro Trp Thr Gln Tyr Ala Ile Phe 
            580                 585                 590         


Val Lys Thr Leu Val Thr Phe Ser Asp Glu Arg Arg Thr Tyr Gly Ala 
        595                 600                 605             


Lys Ser Asp Ile Ile Tyr Val Gln Thr Asp Ala Thr Asn Pro Ser Val 
    610                 615                 620                 


Pro Leu Asp Pro Ile Ser Val Ser Asn Ser Ser Ser Gln Ile Ile Leu 
625                 630                 635                 640 


Lys Trp Lys Pro Pro Ser Asp Pro Asn Gly Asn Ile Thr His Tyr Leu 
                645                 650                 655     


Val Phe Trp Glu Arg Gln Ala Glu Asp Ser Glu Leu Phe Glu Leu Asp 
            660                 665                 670         


Tyr Cys Leu Lys Gly Leu Lys Leu Pro Ser Arg Thr Trp Ser Pro Pro 
        675                 680                 685             


Phe Glu Ser Glu Asp Ser Gln Lys His Asn Gln Ser Glu Tyr Glu Asp 
    690                 695                 700                 


Ser Ala Gly Glu Cys Cys Ser Cys Pro Lys Thr Asp Ser Gln Ile Leu 
705                 710                 715                 720 


Lys Glu Leu Glu Glu Ser Ser Phe Arg Lys Thr Phe Glu Asp Tyr Leu 
                725                 730                 735     


His Asn Val Val Phe Val Pro Arg Lys Thr Ser Ser Gly Thr Gly Ala 
            740                 745                 750         


Glu Asp Pro Arg Pro Ser Arg Lys Arg Arg Ser Leu Gly Asp Val Gly 
        755                 760                 765             


Asn Val Thr Val Ala Val Pro Thr Val Ala Ala Phe Pro Asn Thr Ser 
    770                 775                 780                 


Ser Thr Ser Val Pro Thr Ser Pro Glu Glu His Arg Pro Phe Glu Lys 
785                 790                 795                 800 


Val Val Asn Lys Glu Ser Leu Val Ile Ser Gly Leu Arg His Phe Thr 
                805                 810                 815     


Gly Tyr Arg Ile Glu Leu Gln Ala Cys Asn Gln Asp Thr Pro Glu Glu 
            820                 825                 830         


Arg Cys Ser Val Ala Ala Tyr Val Ser Ala Arg Thr Met Pro Glu Ala 
        835                 840                 845             


Lys Ala Asp Asp Ile Val Gly Pro Val Thr His Glu Ile Phe Glu Asn 
    850                 855                 860                 


Asn Val Val His Leu Met Trp Gln Glu Pro Lys Glu Pro Asn Gly Leu 
865                 870                 875                 880 


Ile Val Leu Tyr Glu Val Ser Tyr Arg Arg Tyr Gly Asp Glu Glu Leu 
                885                 890                 895     


His Leu Cys Val Ser Arg Lys His Phe Ala Leu Glu Arg Gly Cys Arg 
            900                 905                 910         


Leu Arg Gly Leu Ser Pro Gly Asn Tyr Ser Val Arg Ile Arg Ala Thr 
        915                 920                 925             


Ser Leu Ala Gly Asn Gly Ser Trp Thr Glu Pro Thr Tyr Phe Tyr Val 
    930                 935                 940                 


Thr Asp Tyr Leu Asp Val Pro Ser Asn Ile Ala Lys Ile Ile Ile Gly 
945                 950                 955                 960 


Pro Leu Ile Phe Val Phe Leu Phe Ser Val Val Ile Gly Ser Ile Tyr 
                965                 970                 975     


Leu Phe Leu Arg Lys Arg Gln Pro Asp Gly Pro Leu Gly Pro Leu Tyr 
            980                 985                 990         


Ala Ser Ser Asn Pro Glu Tyr Leu  Ser Ala Ser Asp Val  Phe Pro Cys 
        995                 1000                 1005             


Ser Val  Tyr Val Pro Asp Glu  Trp Glu Val Ser Arg  Glu Lys Ile 
    1010                 1015                 1020             


Thr Leu  Leu Arg Glu Leu Gly  Gln Gly Ser Phe Gly  Met Val Tyr 
    1025                 1030                 1035             


Glu Gly  Asn Ala Arg Asp Ile  Ile Lys Gly Glu Ala  Glu Thr Arg 
    1040                 1045                 1050             


Val Ala  Val Lys Thr Val Asn  Glu Ser Ala Ser Leu  Arg Glu Arg 
    1055                 1060                 1065             


Ile Glu  Phe Leu Asn Glu Ala  Ser Val Met Lys Gly  Phe Thr Cys 
    1070                 1075                 1080             


His His  Val Val Arg Leu Leu  Gly Val Val Ser Lys  Gly Gln Pro 
    1085                 1090                 1095             


Thr Leu  Val Val Met Glu Leu  Met Ala His Gly Asp  Leu Lys Ser 
    1100                 1105                 1110             


Tyr Leu  Arg Ser Leu Arg Pro  Glu Ala Glu Asn Asn  Pro Gly Arg 
    1115                 1120                 1125             


Pro Pro  Pro Thr Leu Gln Glu  Met Ile Gln Met Ala  Ala Glu Ile 
    1130                 1135                 1140             


Ala Asp  Gly Met Ala Tyr Leu  Asn Ala Lys Lys Phe  Val His Arg 
    1145                 1150                 1155             


Asp Leu  Ala Ala Arg Asn Cys  Met Val Ala His Asp  Phe Thr Val 
    1160                 1165                 1170             


Lys Ile  Gly Asp Phe Gly Met  Thr Arg Asp Ile Tyr  Glu Thr Asp 
    1175                 1180                 1185             


Tyr Tyr  Arg Lys Gly Gly Lys  Gly Leu Leu Pro Val  Arg Trp Met 
    1190                 1195                 1200             


Ala Pro  Glu Ser Leu Lys Asp  Gly Val Phe Thr Thr  Ser Ser Asp 
    1205                 1210                 1215             


Met Trp  Ser Phe Gly Val Val  Leu Trp Glu Ile Thr  Ser Leu Ala 
    1220                 1225                 1230             


Glu Gln  Pro Tyr Gln Gly Leu  Ser Asn Glu Gln Val  Leu Lys Phe 
    1235                 1240                 1245             


Val Met  Asp Gly Gly Tyr Leu  Asp Gln Pro Asp Asn  Cys Pro Glu 
    1250                 1255                 1260             


Arg Val  Thr Asp Leu Met Arg  Met Cys Trp Gln Phe  Asn Pro Lys 
    1265                 1270                 1275             


Met Arg  Pro Thr Phe Leu Glu  Ile Val Asn Leu Leu  Lys Asp Asp 
    1280                 1285                 1290             


Leu His  Pro Ser Phe Pro Glu  Val Ser Phe Phe His  Ser Glu Glu 
    1295                 1300                 1305             


Asn Lys  Ala Pro Glu Ser Glu  Glu Leu Glu Met Glu  Phe Glu Asp 
    1310                 1315                 1320             


Met Glu  Asn Val Pro Leu Asp  Arg Ser Ser His Cys  Gln Arg Glu 
    1325                 1330                 1335             


Glu Ala  Gly Gly Arg Asp Gly  Gly Ser Ser Leu Gly  Phe Lys Arg 
    1340                 1345                 1350             


Ser Tyr  Glu Glu His Ile Pro  Tyr Thr His Met Asn  Gly Gly Lys 
    1355                 1360                 1365             


Lys Asn  Gly Arg Ile Leu Thr  Leu Pro Arg Ser Asn  Pro Ser 
    1370                 1375                 1380         


<210>  62
<211>  1073
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Ala Ala Ala Gly Gln Leu Cys Leu Leu Tyr Leu Ser Ala Gly Leu 
1               5                   10                  15      


Leu Ser Arg Leu Gly Ala Ala Phe Asn Leu Asp Thr Arg Glu Asp Asn 
            20                  25                  30          


Val Ile Arg Lys Tyr Gly Asp Pro Gly Ser Leu Phe Gly Phe Ser Leu 
        35                  40                  45              


Ala Met His Trp Gln Leu Gln Pro Glu Asp Lys Arg Leu Leu Leu Val 
    50                  55                  60                  


Gly Ala Pro Arg Ala Glu Ala Leu Pro Leu Gln Arg Ala Asn Arg Thr 
65                  70                  75                  80  


Gly Gly Leu Tyr Ser Cys Asp Ile Thr Ala Arg Gly Pro Cys Thr Arg 
                85                  90                  95      


Ile Glu Phe Asp Asn Asp Ala Asp Pro Thr Ser Glu Ser Lys Glu Asp 
            100                 105                 110         


Gln Trp Met Gly Val Thr Val Gln Ser Gln Gly Pro Gly Gly Lys Val 
        115                 120                 125             


Val Thr Cys Ala His Arg Tyr Glu Lys Arg Gln His Val Asn Thr Lys 
    130                 135                 140                 


Gln Glu Ser Arg Asp Ile Phe Gly Arg Cys Tyr Val Leu Ser Gln Asn 
145                 150                 155                 160 


Leu Arg Ile Glu Asp Asp Met Asp Gly Gly Asp Trp Ser Phe Cys Asp 
                165                 170                 175     


Gly Arg Leu Arg Gly His Glu Lys Phe Gly Ser Cys Gln Gln Gly Val 
            180                 185                 190         


Ala Ala Thr Phe Thr Lys Asp Phe His Tyr Ile Val Phe Gly Ala Pro 
        195                 200                 205             


Gly Thr Tyr Asn Trp Lys Gly Ile Val Arg Val Glu Gln Lys Asn Asn 
    210                 215                 220                 


Thr Phe Phe Asp Met Asn Ile Phe Glu Asp Gly Pro Tyr Glu Val Gly 
225                 230                 235                 240 


Gly Glu Thr Glu His Asp Glu Ser Leu Val Pro Val Pro Ala Asn Ser 
                245                 250                 255     


Tyr Leu Gly Phe Ser Leu Asp Ser Gly Lys Gly Ile Val Ser Lys Asp 
            260                 265                 270         


Glu Ile Thr Phe Val Ser Gly Ala Pro Arg Ala Asn His Ser Gly Ala 
        275                 280                 285             


Val Val Leu Leu Lys Arg Asp Met Lys Ser Ala His Leu Leu Pro Glu 
    290                 295                 300                 


His Ile Phe Asp Gly Glu Gly Leu Ala Ser Ser Phe Gly Tyr Asp Val 
305                 310                 315                 320 


Ala Val Val Asp Leu Asn Lys Asp Gly Trp Gln Asp Ile Val Ile Gly 
                325                 330                 335     


Ala Pro Gln Tyr Phe Asp Arg Asp Gly Glu Val Gly Gly Ala Val Tyr 
            340                 345                 350         


Val Tyr Met Asn Gln Gln Gly Arg Trp Asn Asn Val Lys Pro Ile Arg 
        355                 360                 365             


Leu Asn Gly Thr Lys Asp Ser Met Phe Gly Ile Ala Val Lys Asn Ile 
    370                 375                 380                 


Gly Asp Ile Asn Gln Asp Gly Tyr Pro Asp Ile Ala Val Gly Ala Pro 
385                 390                 395                 400 


Tyr Asp Asp Leu Gly Lys Val Phe Ile Tyr His Gly Ser Ala Asn Gly 
                405                 410                 415     


Ile Asn Thr Lys Pro Thr Gln Val Leu Lys Gly Ile Ser Pro Tyr Phe 
            420                 425                 430         


Gly Tyr Ser Ile Ala Gly Asn Met Asp Leu Asp Arg Asn Ser Tyr Pro 
        435                 440                 445             


Asp Val Ala Val Gly Ser Leu Ser Asp Ser Val Thr Ile Phe Arg Ser 
    450                 455                 460                 


Arg Pro Val Ile Asn Ile Gln Lys Thr Ile Thr Val Thr Pro Asn Arg 
465                 470                 475                 480 


Ile Asp Leu Arg Gln Lys Thr Ala Cys Gly Ala Pro Ser Gly Ile Cys 
                485                 490                 495     


Leu Gln Val Lys Ser Cys Phe Glu Tyr Thr Ala Asn Pro Ala Gly Tyr 
            500                 505                 510         


Asn Pro Ser Ile Ser Ile Val Gly Thr Leu Glu Ala Glu Lys Glu Arg 
        515                 520                 525             


Arg Lys Ser Gly Leu Ser Ser Arg Val Gln Phe Arg Asn Gln Gly Ser 
    530                 535                 540                 


Glu Pro Lys Tyr Thr Gln Glu Leu Thr Leu Lys Arg Gln Lys Gln Lys 
545                 550                 555                 560 


Val Cys Met Glu Glu Thr Leu Trp Leu Gln Asp Asn Ile Arg Asp Lys 
                565                 570                 575     


Leu Arg Pro Ile Pro Ile Thr Ala Ser Val Glu Ile Gln Glu Pro Ser 
            580                 585                 590         


Ser Arg Arg Arg Val Asn Ser Leu Pro Glu Val Leu Pro Ile Leu Asn 
        595                 600                 605             


Ser Asp Glu Pro Lys Thr Ala His Ile Asp Val His Phe Leu Lys Glu 
    610                 615                 620                 


Gly Cys Gly Asp Asp Asn Val Cys Asn Ser Asn Leu Lys Leu Glu Tyr 
625                 630                 635                 640 


Lys Phe Cys Thr Arg Glu Gly Asn Gln Asp Lys Phe Ser Tyr Leu Pro 
                645                 650                 655     


Ile Gln Lys Gly Val Pro Glu Leu Val Leu Lys Asp Gln Lys Asp Ile 
            660                 665                 670         


Ala Leu Glu Ile Thr Val Thr Asn Ser Pro Ser Asn Pro Arg Asn Pro 
        675                 680                 685             


Thr Lys Asp Gly Asp Asp Ala His Glu Ala Lys Leu Ile Ala Thr Phe 
    690                 695                 700                 


Pro Asp Thr Leu Thr Tyr Ser Ala Tyr Arg Glu Leu Arg Ala Phe Pro 
705                 710                 715                 720 


Glu Lys Gln Leu Ser Cys Val Ala Asn Gln Asn Gly Ser Gln Ala Asp 
                725                 730                 735     


Cys Glu Leu Gly Asn Pro Phe Lys Arg Asn Ser Asn Val Thr Phe Tyr 
            740                 745                 750         


Leu Val Leu Ser Thr Thr Glu Val Thr Phe Asp Thr Pro Asp Leu Asp 
        755                 760                 765             


Ile Asn Leu Lys Leu Glu Thr Thr Ser Asn Gln Asp Asn Leu Ala Pro 
    770                 775                 780                 


Ile Thr Ala Lys Ala Lys Val Val Ile Glu Leu Leu Leu Ser Val Ser 
785                 790                 795                 800 


Gly Val Ala Lys Pro Ser Gln Val Tyr Phe Gly Gly Thr Val Val Gly 
                805                 810                 815     


Glu Gln Ala Met Lys Ser Glu Asp Glu Val Gly Ser Leu Ile Glu Tyr 
            820                 825                 830         


Glu Phe Arg Val Ile Asn Leu Gly Lys Pro Leu Thr Asn Leu Gly Thr 
        835                 840                 845             


Ala Thr Leu Asn Ile Gln Trp Pro Lys Glu Ile Ser Asn Gly Lys Trp 
    850                 855                 860                 


Leu Leu Tyr Leu Val Lys Val Glu Ser Lys Gly Leu Glu Lys Val Thr 
865                 870                 875                 880 


Cys Glu Pro Gln Lys Glu Ile Asn Ser Leu Asn Leu Thr Glu Ser His 
                885                 890                 895     


Asn Ser Arg Lys Lys Arg Glu Ile Thr Glu Lys Gln Ile Asp Asp Asn 
            900                 905                 910         


Arg Lys Phe Ser Leu Phe Ala Glu Arg Lys Tyr Gln Thr Leu Asn Cys 
        915                 920                 925             


Ser Val Asn Val Asn Cys Val Asn Ile Arg Cys Pro Leu Arg Gly Leu 
    930                 935                 940                 


Asp Ser Lys Ala Ser Leu Ile Leu Arg Ser Arg Leu Trp Asn Ser Thr 
945                 950                 955                 960 


Phe Leu Glu Glu Tyr Ser Lys Leu Asn Tyr Leu Asp Ile Leu Met Arg 
                965                 970                 975     


Ala Phe Ile Asp Val Thr Ala Ala Ala Glu Asn Ile Arg Leu Pro Asn 
            980                 985                 990         


Ala Gly Thr Gln Val Arg Val Thr  Val Phe Pro Ser Lys  Thr Val Ala 
        995                 1000                 1005             


Gln Tyr  Ser Gly Val Pro Trp  Trp Ile Ile Leu Val  Ala Ile Leu 
    1010                 1015                 1020             


Ala Gly  Ile Leu Met Leu Ala  Leu Leu Val Phe Ile  Leu Trp Lys 
    1025                 1030                 1035             


Cys Gly  Phe Phe Lys Arg Asn  Lys Lys Asp His Tyr  Asp Ala Thr 
    1040                 1045                 1050             


Tyr His  Lys Ala Glu Ile His  Ala Gln Pro Ser Asp  Lys Glu Arg 
    1055                 1060                 1065             


Leu Thr  Ser Asp Ala 
    1070             


<210>  63
<211>  769
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser 
            20                  25                  30          


Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr 
    50                  55                  60                  


Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp 
65                  70                  75                  80  


Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Asp Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asn Asn Ser Asn Gln Phe Gln Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Asn Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Ser Arg Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Ser Asn Val 
            340                 345                 350         


Val His Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Asn Ala Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Gly Val Thr His Arg Asn Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Val Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Ile Val Thr Val Gln Val Leu Pro Gln Cys Glu Cys Arg 
        435                 440                 445             


Cys Arg Asp Gln Ser Arg Asp Arg Ser Leu Cys His Gly Lys Gly Phe 
    450                 455                 460                 


Leu Glu Cys Gly Ile Cys Arg Cys Asp Thr Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Asn Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Val Cys Gly Gln Cys Leu Cys His Thr Ser Asp Val Pro Gly Lys Leu 
        515                 520                 525             


Ile Tyr Gly Gln Tyr Cys Glu Cys Asp Thr Ile Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asn Gly Gln Val Cys Gly Gly Pro Gly Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 


Lys Cys Arg Cys His Pro Gly Phe Glu Gly Ser Ala Cys Gln Cys Glu 
                565                 570                 575     


Arg Thr Thr Glu Gly Cys Leu Asn Pro Arg Arg Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Glu Cys His Ser Gly Tyr Gln 
        595                 600                 605             


Leu Pro Leu Cys Gln Glu Cys Pro Gly Cys Pro Ser Pro Cys Gly Lys 
    610                 615                 620                 


Tyr Ile Ser Cys Ala Glu Cys Leu Lys Phe Glu Lys Gly Pro Phe Gly 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Ala Cys Pro Gly Leu Gln Leu Ser Asn Asn Pro 
                645                 650                 655     


Val Lys Gly Arg Thr Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Val 
            660                 665                 670         


Ala Tyr Thr Leu Glu Gln Gln Asp Gly Met Asp Arg Tyr Leu Ile Tyr 
        675                 680                 685             


Val Asp Glu Ser Arg Glu Cys Val Ala Gly Pro Asn Ile Ala Ala Ile 
    690                 695                 700                 


Val Gly Gly Thr Val Ala Gly Ile Val Leu Ile Gly Ile Leu Leu Leu 
705                 710                 715                 720 


Val Ile Trp Lys Ala Leu Ile His Leu Ser Asp Leu Arg Glu Tyr Arg 
                725                 730                 735     


Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro 
            740                 745                 750         


Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu 
        755                 760                 765             


Ser 
    


<210>  64
<211>  788
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Arg Ala Arg Pro Arg Pro Arg Pro Leu Trp Ala Thr Val Leu Ala 
1               5                   10                  15      


Leu Gly Ala Leu Ala Gly Val Gly Val Gly Gly Pro Asn Ile Cys Thr 
            20                  25                  30          


Thr Arg Gly Val Ser Ser Cys Gln Gln Cys Leu Ala Val Ser Pro Met 
        35                  40                  45              


Cys Ala Trp Cys Ser Asp Glu Ala Leu Pro Leu Gly Ser Pro Arg Cys 
    50                  55                  60                  


Asp Leu Lys Glu Asn Leu Leu Lys Asp Asn Cys Ala Pro Glu Ser Ile 
65                  70                  75                  80  


Glu Phe Pro Val Ser Glu Ala Arg Val Leu Glu Asp Arg Pro Leu Ser 
                85                  90                  95      


Asp Lys Gly Ser Gly Asp Ser Ser Gln Val Thr Gln Val Ser Pro Gln 
            100                 105                 110         


Arg Ile Ala Leu Arg Leu Arg Pro Asp Asp Ser Lys Asn Phe Ser Ile 
        115                 120                 125             


Gln Val Arg Gln Val Glu Asp Tyr Pro Val Asp Ile Tyr Tyr Leu Met 
    130                 135                 140                 


Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Trp Ser Ile Gln Asn Leu 
145                 150                 155                 160 


Gly Thr Lys Leu Ala Thr Gln Met Arg Lys Leu Thr Ser Asn Leu Arg 
                165                 170                 175     


Ile Gly Phe Gly Ala Phe Val Asp Lys Pro Val Ser Pro Tyr Met Tyr 
            180                 185                 190         


Ile Ser Pro Pro Glu Ala Leu Glu Asn Pro Cys Tyr Asp Met Lys Thr 
        195                 200                 205             


Thr Cys Leu Pro Met Phe Gly Tyr Lys His Val Leu Thr Leu Thr Asp 
    210                 215                 220                 


Gln Val Thr Arg Phe Asn Glu Glu Val Lys Lys Gln Ser Val Ser Arg 
225                 230                 235                 240 


Asn Arg Asp Ala Pro Glu Gly Gly Phe Asp Ala Ile Met Gln Ala Thr 
                245                 250                 255     


Val Cys Asp Glu Lys Ile Gly Trp Arg Asn Asp Ala Ser His Leu Leu 
            260                 265                 270         


Val Phe Thr Thr Asp Ala Lys Thr His Ile Ala Leu Asp Gly Arg Leu 
        275                 280                 285             


Ala Gly Ile Val Gln Pro Asn Asp Gly Gln Cys His Val Gly Ser Asp 
    290                 295                 300                 


Asn His Tyr Ser Ala Ser Thr Thr Met Asp Tyr Pro Ser Leu Gly Leu 
305                 310                 315                 320 


Met Thr Glu Lys Leu Ser Gln Lys Asn Ile Asn Leu Ile Phe Ala Val 
                325                 330                 335     


Thr Glu Asn Val Val Asn Leu Tyr Gln Asn Tyr Ser Glu Leu Ile Pro 
            340                 345                 350         


Gly Thr Thr Val Gly Val Leu Ser Met Asp Ser Ser Asn Val Leu Gln 
        355                 360                 365             


Leu Ile Val Asp Ala Tyr Gly Lys Ile Arg Ser Lys Val Glu Leu Glu 
    370                 375                 380                 


Val Arg Asp Leu Pro Glu Glu Leu Ser Leu Ser Phe Asn Ala Thr Cys 
385                 390                 395                 400 


Leu Asn Asn Glu Val Ile Pro Gly Leu Lys Ser Cys Met Gly Leu Lys 
                405                 410                 415     


Ile Gly Asp Thr Val Ser Phe Ser Ile Glu Ala Lys Val Arg Gly Cys 
            420                 425                 430         


Pro Gln Glu Lys Glu Lys Ser Phe Thr Ile Lys Pro Val Gly Phe Lys 
        435                 440                 445             


Asp Ser Leu Ile Val Gln Val Thr Phe Asp Cys Asp Cys Ala Cys Gln 
    450                 455                 460                 


Ala Gln Ala Glu Pro Asn Ser His Arg Cys Asn Asn Gly Asn Gly Thr 
465                 470                 475                 480 


Phe Glu Cys Gly Val Cys Arg Cys Gly Pro Gly Trp Leu Gly Ser Gln 
                485                 490                 495     


Cys Glu Cys Ser Glu Glu Asp Tyr Arg Pro Ser Gln Gln Asp Glu Cys 
            500                 505                 510         


Ser Pro Arg Glu Gly Gln Pro Val Cys Ser Gln Arg Gly Glu Cys Leu 
        515                 520                 525             


Cys Gly Gln Cys Val Cys His Ser Ser Asp Phe Gly Lys Ile Thr Gly 
    530                 535                 540                 


Lys Tyr Cys Glu Cys Asp Asp Phe Ser Cys Val Arg Tyr Lys Gly Glu 
545                 550                 555                 560 


Met Cys Ser Gly His Gly Gln Cys Ser Cys Gly Asp Cys Leu Cys Asp 
                565                 570                 575     


Ser Asp Trp Thr Gly Tyr Tyr Cys Asn Cys Thr Thr Arg Thr Asp Thr 
            580                 585                 590         


Cys Met Ser Ser Asn Gly Leu Leu Cys Ser Gly Arg Gly Lys Cys Glu 
        595                 600                 605             


Cys Gly Ser Cys Val Cys Ile Gln Pro Gly Ser Tyr Gly Asp Thr Cys 
    610                 615                 620                 


Glu Lys Cys Pro Thr Cys Pro Asp Ala Cys Thr Phe Lys Lys Glu Cys 
625                 630                 635                 640 


Val Glu Cys Lys Lys Phe Asp Arg Gly Ala Leu His Asp Glu Asn Thr 
                645                 650                 655     


Cys Asn Arg Tyr Cys Arg Asp Glu Ile Glu Ser Val Lys Glu Leu Lys 
            660                 665                 670         


Asp Thr Gly Lys Asp Ala Val Asn Cys Thr Tyr Lys Asn Glu Asp Asp 
        675                 680                 685             


Cys Val Val Arg Phe Gln Tyr Tyr Glu Asp Ser Ser Gly Lys Ser Ile 
    690                 695                 700                 


Leu Tyr Val Val Glu Glu Pro Glu Cys Pro Lys Gly Pro Asp Ile Leu 
705                 710                 715                 720 


Val Val Leu Leu Ser Val Met Gly Ala Ile Leu Leu Ile Gly Leu Ala 
                725                 730                 735     


Ala Leu Leu Ile Trp Lys Leu Leu Ile Thr Ile His Asp Arg Lys Glu 
            740                 745                 750         


Phe Ala Lys Phe Glu Glu Glu Arg Ala Arg Ala Lys Trp Asp Thr Ala 
        755                 760                 765             


Asn Asn Pro Leu Tyr Lys Glu Ala Thr Ser Thr Phe Thr Asn Ile Thr 
    770                 775                 780                 


Tyr Arg Gly Thr 
785             


<210>  65
<211>  1218
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Arg Ser Pro Arg Thr Arg Gly Arg Ser Gly Arg Pro Leu Ser Leu 
1               5                   10                  15      


Leu Leu Ala Leu Leu Cys Ala Leu Arg Ala Lys Val Cys Gly Ala Ser 
            20                  25                  30          


Gly Gln Phe Glu Leu Glu Ile Leu Ser Met Gln Asn Val Asn Gly Glu 
        35                  40                  45              


Leu Gln Asn Gly Asn Cys Cys Gly Gly Ala Arg Asn Pro Gly Asp Arg 
    50                  55                  60                  


Lys Cys Thr Arg Asp Glu Cys Asp Thr Tyr Phe Lys Val Cys Leu Lys 
65                  70                  75                  80  


Glu Tyr Gln Ser Arg Val Thr Ala Gly Gly Pro Cys Ser Phe Gly Ser 
                85                  90                  95      


Gly Ser Thr Pro Val Ile Gly Gly Asn Thr Phe Asn Leu Lys Ala Ser 
            100                 105                 110         


Arg Gly Asn Asp Arg Asn Arg Ile Val Leu Pro Phe Ser Phe Ala Trp 
        115                 120                 125             


Pro Arg Ser Tyr Thr Leu Leu Val Glu Ala Trp Asp Ser Ser Asn Asp 
    130                 135                 140                 


Thr Val Gln Pro Asp Ser Ile Ile Glu Lys Ala Ser His Ser Gly Met 
145                 150                 155                 160 


Ile Asn Pro Ser Arg Gln Trp Gln Thr Leu Lys Gln Asn Thr Gly Val 
                165                 170                 175     


Ala His Phe Glu Tyr Gln Ile Arg Val Thr Cys Asp Asp Tyr Tyr Tyr 
            180                 185                 190         


Gly Phe Gly Cys Asn Lys Phe Cys Arg Pro Arg Asp Asp Phe Phe Gly 
        195                 200                 205             


His Tyr Ala Cys Asp Gln Asn Gly Asn Lys Thr Cys Met Glu Gly Trp 
    210                 215                 220                 


Met Gly Pro Glu Cys Asn Arg Ala Ile Cys Arg Gln Gly Cys Ser Pro 
225                 230                 235                 240 


Lys His Gly Ser Cys Lys Leu Pro Gly Asp Cys Arg Cys Gln Tyr Gly 
                245                 250                 255     


Trp Gln Gly Leu Tyr Cys Asp Lys Cys Ile Pro His Pro Gly Cys Val 
            260                 265                 270         


His Gly Ile Cys Asn Glu Pro Trp Gln Cys Leu Cys Glu Thr Asn Trp 
        275                 280                 285             


Gly Gly Gln Leu Cys Asp Lys Asp Leu Asn Tyr Cys Gly Thr His Gln 
    290                 295                 300                 


Pro Cys Leu Asn Gly Gly Thr Cys Ser Asn Thr Gly Pro Asp Lys Tyr 
305                 310                 315                 320 


Gln Cys Ser Cys Pro Glu Gly Tyr Ser Gly Pro Asn Cys Glu Ile Ala 
                325                 330                 335     


Glu His Ala Cys Leu Ser Asp Pro Cys His Asn Arg Gly Ser Cys Lys 
            340                 345                 350         


Glu Thr Ser Leu Gly Phe Glu Cys Glu Cys Ser Pro Gly Trp Thr Gly 
        355                 360                 365             


Pro Thr Cys Ser Thr Asn Ile Asp Asp Cys Ser Pro Asn Asn Cys Ser 
    370                 375                 380                 


His Gly Gly Thr Cys Gln Asp Leu Val Asn Gly Phe Lys Cys Val Cys 
385                 390                 395                 400 


Pro Pro Gln Trp Thr Gly Lys Thr Cys Gln Leu Asp Ala Asn Glu Cys 
                405                 410                 415     


Glu Ala Lys Pro Cys Val Asn Ala Lys Ser Cys Lys Asn Leu Ile Ala 
            420                 425                 430         


Ser Tyr Tyr Cys Asp Cys Leu Pro Gly Trp Met Gly Gln Asn Cys Asp 
        435                 440                 445             


Ile Asn Ile Asn Asp Cys Leu Gly Gln Cys Gln Asn Asp Ala Ser Cys 
    450                 455                 460                 


Arg Asp Leu Val Asn Gly Tyr Arg Cys Ile Cys Pro Pro Gly Tyr Ala 
465                 470                 475                 480 


Gly Asp His Cys Glu Arg Asp Ile Asp Glu Cys Ala Ser Asn Pro Cys 
                485                 490                 495     


Leu Asn Gly Gly His Cys Gln Asn Glu Ile Asn Arg Phe Gln Cys Leu 
            500                 505                 510         


Cys Pro Thr Gly Phe Ser Gly Asn Leu Cys Gln Leu Asp Ile Asp Tyr 
        515                 520                 525             


Cys Glu Pro Asn Pro Cys Gln Asn Gly Ala Gln Cys Tyr Asn Arg Ala 
    530                 535                 540                 


Ser Asp Tyr Phe Cys Lys Cys Pro Glu Asp Tyr Glu Gly Lys Asn Cys 
545                 550                 555                 560 


Ser His Leu Lys Asp His Cys Arg Thr Thr Pro Cys Glu Val Ile Asp 
                565                 570                 575     


Ser Cys Thr Val Ala Met Ala Ser Asn Asp Thr Pro Glu Gly Val Arg 
            580                 585                 590         


Tyr Ile Ser Ser Asn Val Cys Gly Pro His Gly Lys Cys Lys Ser Gln 
        595                 600                 605             


Ser Gly Gly Lys Phe Thr Cys Asp Cys Asn Lys Gly Phe Thr Gly Thr 
    610                 615                 620                 


Tyr Cys His Glu Asn Ile Asn Asp Cys Glu Ser Asn Pro Cys Arg Asn 
625                 630                 635                 640 


Gly Gly Thr Cys Ile Asp Gly Val Asn Ser Tyr Lys Cys Ile Cys Ser 
                645                 650                 655     


Asp Gly Trp Glu Gly Ala Tyr Cys Glu Thr Asn Ile Asn Asp Cys Ser 
            660                 665                 670         


Gln Asn Pro Cys His Asn Gly Gly Thr Cys Arg Asp Leu Val Asn Asp 
        675                 680                 685             


Phe Tyr Cys Asp Cys Lys Asn Gly Trp Lys Gly Lys Thr Cys His Ser 
    690                 695                 700                 


Arg Asp Ser Gln Cys Asp Glu Ala Thr Cys Asn Asn Gly Gly Thr Cys 
705                 710                 715                 720 


Tyr Asp Glu Gly Asp Ala Phe Lys Cys Met Cys Pro Gly Gly Trp Glu 
                725                 730                 735     


Gly Thr Thr Cys Asn Ile Ala Arg Asn Ser Ser Cys Leu Pro Asn Pro 
            740                 745                 750         


Cys His Asn Gly Gly Thr Cys Val Val Asn Gly Glu Ser Phe Thr Cys 
        755                 760                 765             


Val Cys Lys Glu Gly Trp Glu Gly Pro Ile Cys Ala Gln Asn Thr Asn 
    770                 775                 780                 


Asp Cys Ser Pro His Pro Cys Tyr Asn Ser Gly Thr Cys Val Asp Gly 
785                 790                 795                 800 


Asp Asn Trp Tyr Arg Cys Glu Cys Ala Pro Gly Phe Ala Gly Pro Asp 
                805                 810                 815     


Cys Arg Ile Asn Ile Asn Glu Cys Gln Ser Ser Pro Cys Ala Phe Gly 
            820                 825                 830         


Ala Thr Cys Val Asp Glu Ile Asn Gly Tyr Arg Cys Val Cys Pro Pro 
        835                 840                 845             


Gly His Ser Gly Ala Lys Cys Gln Glu Val Ser Gly Arg Pro Cys Ile 
    850                 855                 860                 


Thr Met Gly Ser Val Ile Pro Asp Gly Ala Lys Trp Asp Asp Asp Cys 
865                 870                 875                 880 


Asn Thr Cys Gln Cys Leu Asn Gly Arg Ile Ala Cys Ser Lys Val Trp 
                885                 890                 895     


Cys Gly Pro Arg Pro Cys Leu Leu His Lys Gly His Ser Glu Cys Pro 
            900                 905                 910         


Ser Gly Gln Ser Cys Ile Pro Ile Leu Asp Asp Gln Cys Phe Val His 
        915                 920                 925             


Pro Cys Thr Gly Val Gly Glu Cys Arg Ser Ser Ser Leu Gln Pro Val 
    930                 935                 940                 


Lys Thr Lys Cys Thr Ser Asp Ser Tyr Tyr Gln Asp Asn Cys Ala Asn 
945                 950                 955                 960 


Ile Thr Phe Thr Phe Asn Lys Glu Met Met Ser Pro Gly Leu Thr Thr 
                965                 970                 975     


Glu His Ile Cys Ser Glu Leu Arg Asn Leu Asn Ile Leu Lys Asn Val 
            980                 985                 990         


Ser Ala Glu Tyr Ser Ile Tyr Ile  Ala Cys Glu Pro Ser  Pro Ser Ala 
        995                 1000                 1005             


Asn Asn  Glu Ile His Val Ala  Ile Ser Ala Glu Asp  Ile Arg Asp 
    1010                 1015                 1020             


Asp Gly  Asn Pro Ile Lys Glu  Ile Thr Asp Lys Ile  Ile Asp Leu 
    1025                 1030                 1035             


Val Ser  Lys Arg Asp Gly Asn  Ser Ser Leu Ile Ala  Ala Val Ala 
    1040                 1045                 1050             


Glu Val  Arg Val Gln Arg Arg  Pro Leu Lys Asn Arg  Thr Asp Phe 
    1055                 1060                 1065             


Leu Val  Pro Leu Leu Ser Ser  Val Leu Thr Val Ala  Trp Ile Cys 
    1070                 1075                 1080             


Cys Leu  Val Thr Ala Phe Tyr  Trp Cys Leu Arg Lys  Arg Arg Lys 
    1085                 1090                 1095             


Pro Gly  Ser His Thr His Ser  Ala Ser Glu Asp Asn  Thr Thr Asn 
    1100                 1105                 1110             


Asn Val  Arg Glu Gln Leu Asn  Gln Ile Lys Asn Pro  Ile Glu Lys 
    1115                 1120                 1125             


His Gly  Ala Asn Thr Val Pro  Ile Lys Asp Tyr Glu  Asn Lys Asn 
    1130                 1135                 1140             


Ser Lys  Met Ser Lys Ile Arg  Thr His Asn Ser Glu  Val Glu Glu 
    1145                 1150                 1155             


Asp Asp  Met Asp Lys His Gln  Gln Lys Ala Arg Phe  Ala Lys Gln 
    1160                 1165                 1170             


Pro Ala  Tyr Thr Leu Val Asp  Arg Glu Glu Lys Pro  Pro Asn Gly 
    1175                 1180                 1185             


Thr Pro  Thr Lys His Pro Asn  Trp Thr Asn Lys Gln  Asp Asn Arg 
    1190                 1195                 1200             


Asp Leu  Glu Ser Ala Gln Ser  Leu Asn Arg Met Glu  Tyr Ile Val 
    1205                 1210                 1215             


<210>  66
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Thr Val Met Ser Gly Glu Asn Val Asp Glu Ala Ser Ala Ala Pro 
1               5                   10                  15      


Gly His Pro Gln Asp Gly Ser Tyr Pro Arg Gln Ala Asp His Asp Asp 
            20                  25                  30          


His Glu Cys Cys Glu Arg Val Val Ile Asn Ile Ser Gly Leu Arg Phe 
        35                  40                  45              


Glu Thr Gln Leu Lys Thr Leu Ala Gln Phe Pro Asn Thr Leu Leu Gly 
    50                  55                  60                  


Asn Pro Lys Lys Arg Met Arg Tyr Phe Asp Pro Leu Arg Asn Glu Tyr 
65                  70                  75                  80  


Phe Phe Asp Arg Asn Arg Pro Ser Phe Asp Ala Ile Leu Tyr Tyr Tyr 
                85                  90                  95      


Gln Ser Gly Gly Arg Leu Arg Arg Pro Val Asn Val Pro Leu Asp Met 
            100                 105                 110         


Phe Ser Glu Glu Ile Lys Phe Tyr Glu Leu Gly Glu Glu Ala Met Glu 
        115                 120                 125             


Lys Phe Arg Glu Asp Glu Gly Phe Ile Lys Glu Glu Glu Arg Pro Leu 
    130                 135                 140                 


Pro Glu Lys Glu Tyr Gln Arg Gln Val Trp Leu Leu Phe Glu Tyr Pro 
145                 150                 155                 160 


Glu Ser Ser Gly Pro Ala Arg Val Ile Ala Ile Val Ser Val Met Val 
                165                 170                 175     


Ile Leu Ile Ser Ile Val Ile Phe Cys Leu Glu Thr Leu Pro Glu Leu 
            180                 185                 190         


Lys Asp Asp Lys Asp Phe Thr Gly Thr Val His Arg Ile Asp Asn Thr 
        195                 200                 205             


Thr Val Ile Tyr Asn Ser Asn Ile Phe Thr Asp Pro Phe Phe Ile Val 
    210                 215                 220                 


Glu Thr Leu Cys Ile Ile Trp Phe Ser Phe Glu Leu Val Val Arg Phe 
225                 230                 235                 240 


Phe Ala Cys Pro Ser Lys Thr Asp Phe Phe Lys Asn Ile Met Asn Phe 
                245                 250                 255     


Ile Asp Ile Val Ala Ile Ile Pro Tyr Phe Ile Thr Leu Gly Thr Glu 
            260                 265                 270         


Ile Ala Glu Gln Glu Gly Asn Gln Lys Gly Glu Gln Ala Thr Ser Leu 
        275                 280                 285             


Ala Ile Leu Arg Val Ile Arg Leu Val Arg Val Phe Arg Ile Phe Lys 
    290                 295                 300                 


Leu Ser Arg His Ser Lys Gly Leu Gln Ile Leu Gly Gln Thr Leu Lys 
305                 310                 315                 320 


Ala Ser Met Arg Glu Leu Gly Leu Leu Ile Phe Phe Leu Phe Ile Gly 
                325                 330                 335     


Val Ile Leu Phe Ser Ser Ala Val Tyr Phe Ala Glu Ala Glu Glu Ala 
            340                 345                 350         


Glu Ser His Phe Ser Ser Ile Pro Asp Ala Phe Trp Trp Ala Val Val 
        355                 360                 365             


Ser Met Thr Thr Val Gly Tyr Gly Asp Met Tyr Pro Val Thr Ile Gly 
    370                 375                 380                 


Gly Lys Ile Val Gly Ser Leu Cys Ala Ile Ala Gly Val Leu Thr Ile 
385                 390                 395                 400 


Ala Leu Pro Val Pro Val Ile Val Ser Asn Phe Asn Tyr Phe Tyr His 
                405                 410                 415     


Arg Glu Thr Glu Gly Glu Glu Gln Ala Gln Leu Leu His Val Ser Ser 
            420                 425                 430         


Pro Asn Leu Ala Ser Asp Ser Asp Leu Ser Arg Arg Ser Ser Ser Thr 
        435                 440                 445             


Met Ser Lys Ser Glu Tyr Met Glu Ile Glu Glu Asp Met Asn Asn Ser 
    450                 455                 460                 


Ile Ala His Tyr Arg Gln Val Asn Ile Arg Thr Ala Asn Cys Thr Thr 
465                 470                 475                 480 


Ala Asn Gln Asn Cys Val Asn Lys Ser Lys Leu Leu Thr Asp Val 
                485                 490                 495 


<210>  67
<211>  676
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Ala Ala Ala Ser Ser Pro Pro Arg Ala Glu Arg Lys Arg Trp Gly 
1               5                   10                  15      


Trp Gly Arg Leu Pro Gly Ala Arg Arg Gly Ser Ala Gly Leu Ala Lys 
            20                  25                  30          


Lys Cys Pro Phe Ser Leu Glu Leu Ala Glu Gly Gly Pro Ala Gly Gly 
        35                  40                  45              


Ala Leu Tyr Ala Pro Ile Ala Pro Gly Ala Pro Gly Pro Ala Pro Pro 
    50                  55                  60                  


Ala Ser Pro Ala Ala Pro Ala Ala Pro Pro Val Ala Ser Asp Leu Gly 
65                  70                  75                  80  


Pro Arg Pro Pro Val Ser Leu Asp Pro Arg Val Ser Ile Tyr Ser Thr 
                85                  90                  95      


Arg Arg Pro Val Leu Ala Arg Thr His Val Gln Gly Arg Val Tyr Asn 
            100                 105                 110         


Phe Leu Glu Arg Pro Thr Gly Trp Lys Cys Phe Val Tyr His Phe Ala 
        115                 120                 125             


Val Phe Leu Ile Val Leu Val Cys Leu Ile Phe Ser Val Leu Ser Thr 
    130                 135                 140                 


Ile Glu Gln Tyr Ala Ala Leu Ala Thr Gly Thr Leu Phe Trp Met Glu 
145                 150                 155                 160 


Ile Val Leu Val Val Phe Phe Gly Thr Glu Tyr Val Val Arg Leu Trp 
                165                 170                 175     


Ser Ala Gly Cys Arg Ser Lys Tyr Val Gly Leu Trp Gly Arg Leu Arg 
            180                 185                 190         


Phe Ala Arg Lys Pro Ile Ser Ile Ile Asp Leu Ile Val Val Val Ala 
        195                 200                 205             


Ser Met Val Val Leu Cys Val Gly Ser Lys Gly Gln Val Phe Ala Thr 
    210                 215                 220                 


Ser Ala Ile Arg Gly Ile Arg Phe Leu Gln Ile Leu Arg Met Leu His 
225                 230                 235                 240 


Val Asp Arg Gln Gly Gly Thr Trp Arg Leu Leu Gly Ser Val Val Phe 
                245                 250                 255     


Ile His Arg Gln Glu Leu Ile Thr Thr Leu Tyr Ile Gly Phe Leu Gly 
            260                 265                 270         


Leu Ile Phe Ser Ser Tyr Phe Val Tyr Leu Ala Glu Lys Asp Ala Val 
        275                 280                 285             


Asn Glu Ser Gly Arg Val Glu Phe Gly Ser Tyr Ala Asp Ala Leu Trp 
    290                 295                 300                 


Trp Gly Val Val Thr Val Thr Thr Ile Gly Tyr Gly Asp Lys Val Pro 
305                 310                 315                 320 


Gln Thr Trp Val Gly Lys Thr Ile Ala Ser Cys Phe Ser Val Phe Ala 
                325                 330                 335     


Ile Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu Gly Ser Gly Phe Ala 
            340                 345                 350         


Leu Lys Val Gln Gln Lys Gln Arg Gln Lys His Phe Asn Arg Gln Ile 
        355                 360                 365             


Pro Ala Ala Ala Ser Leu Ile Gln Thr Ala Trp Arg Cys Tyr Ala Ala 
    370                 375                 380                 


Glu Asn Pro Asp Ser Ser Thr Trp Lys Ile Tyr Ile Arg Lys Ala Pro 
385                 390                 395                 400 


Arg Ser His Thr Leu Leu Ser Pro Ser Pro Lys Pro Lys Lys Ser Val 
                405                 410                 415     


Val Val Lys Lys Lys Lys Phe Lys Leu Asp Lys Asp Asn Gly Val Thr 
            420                 425                 430         


Pro Gly Glu Lys Met Leu Thr Val Pro His Ile Thr Cys Asp Pro Pro 
        435                 440                 445             


Glu Glu Arg Arg Leu Asp His Phe Ser Val Asp Gly Tyr Asp Ser Ser 
    450                 455                 460                 


Val Arg Lys Ser Pro Thr Leu Leu Glu Val Ser Met Pro His Phe Met 
465                 470                 475                 480 


Arg Thr Asn Ser Phe Ala Glu Asp Leu Asp Leu Glu Gly Glu Thr Leu 
                485                 490                 495     


Leu Thr Pro Ile Thr His Ile Ser Gln Leu Arg Glu His His Arg Ala 
            500                 505                 510         


Thr Ile Lys Val Ile Arg Arg Met Gln Tyr Phe Val Ala Lys Lys Lys 
        515                 520                 525             


Phe Gln Gln Ala Arg Lys Pro Tyr Asp Val Arg Asp Val Ile Glu Gln 
    530                 535                 540                 


Tyr Ser Gln Gly His Leu Asn Leu Met Val Arg Ile Lys Glu Leu Gln 
545                 550                 555                 560 


Arg Arg Leu Asp Gln Ser Ile Gly Lys Pro Ser Leu Phe Ile Ser Val 
                565                 570                 575     


Ser Glu Lys Ser Lys Asp Arg Gly Ser Asn Thr Ile Gly Ala Arg Leu 
            580                 585                 590         


Asn Arg Val Glu Asp Lys Val Thr Gln Leu Asp Gln Arg Leu Ala Leu 
        595                 600                 605             


Ile Thr Asp Met Leu His Gln Leu Leu Ser Leu His Gly Gly Ser Thr 
    610                 615                 620                 


Pro Gly Ser Gly Gly Pro Pro Arg Glu Gly Gly Ala His Ile Thr Gln 
625                 630                 635                 640 


Pro Cys Gly Ser Gly Gly Ser Val Asp Pro Glu Leu Phe Leu Pro Ser 
                645                 650                 655     


Asn Thr Leu Pro Thr Tyr Glu Gln Leu Thr Val Pro Arg Arg Gly Pro 
            660                 665                 670         


Asp Glu Gly Ser 
        675     


<210>  68
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Ile Leu Ser Asn Thr Thr Ala Val Thr Pro Phe Leu Thr Lys Leu 
1               5                   10                  15      


Trp Gln Glu Thr Val Gln Gln Gly Gly Asn Met Ser Gly Leu Ala Arg 
            20                  25                  30          


Arg Ser Pro Arg Ser Ser Asp Gly Lys Leu Glu Ala Leu Tyr Val Leu 
        35                  40                  45              


Met Val Leu Gly Phe Phe Gly Phe Phe Thr Leu Gly Ile Met Leu Ser 
    50                  55                  60                  


Tyr Ile Arg Ser Lys Lys Leu Glu His Ser Asn Asp Pro Phe Asn Val 
65                  70                  75                  80  


Tyr Ile Glu Ser Asp Ala Trp Gln Glu Lys Asp Lys Ala Tyr Val Gln 
                85                  90                  95      


Ala Arg Val Leu Glu Ser Tyr Arg Ser Cys Tyr Val Val Glu Asn His 
            100                 105                 110         


Leu Ala Ile Glu Gln Pro Asn Thr His Leu Pro Glu Thr Lys Pro Ser 
        115                 120                 125             


Pro 
    


<210>  69
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Asn Ala Ser Ser Arg Asn Val Phe Asp Thr Leu Ile Arg Val Leu 
1               5                   10                  15      


Thr Glu Ser Met Phe Lys His Leu Arg Lys Trp Val Val Thr Arg Phe 
            20                  25                  30          


Phe Gly His Ser Arg Gln Arg Ala Arg Leu Val Ser Lys Asp Gly Arg 
        35                  40                  45              


Cys Asn Ile Glu Phe Gly Asn Val Glu Ala Gln Ser Arg Phe Ile Phe 
    50                  55                  60                  


Phe Val Asp Ile Trp Thr Thr Val Leu Asp Leu Lys Trp Arg Tyr Lys 
65                  70                  75                  80  


Met Thr Ile Phe Ile Thr Ala Phe Leu Gly Ser Trp Phe Phe Phe Gly 
                85                  90                  95      


Leu Leu Trp Tyr Ala Val Ala Tyr Ile His Lys Asp Leu Pro Glu Phe 
            100                 105                 110         


His Pro Ser Ala Asn His Thr Pro Cys Val Glu Asn Ile Asn Gly Leu 
        115                 120                 125             


Thr Ser Ala Phe Leu Phe Ser Leu Glu Thr Gln Val Thr Ile Gly Tyr 
    130                 135                 140                 


Gly Phe Arg Cys Val Thr Glu Gln Cys Ala Thr Ala Ile Phe Leu Leu 
145                 150                 155                 160 


Ile Phe Gln Ser Ile Leu Gly Val Ile Ile Asn Ser Phe Met Cys Gly 
                165                 170                 175     


Ala Ile Leu Ala Lys Ile Ser Arg Pro Lys Lys Arg Ala Lys Thr Ile 
            180                 185                 190         


Thr Phe Ser Lys Asn Ala Val Ile Ser Lys Arg Gly Gly Lys Leu Cys 
        195                 200                 205             


Leu Leu Ile Arg Val Ala Asn Leu Arg Lys Ser Leu Leu Ile Gly Ser 
    210                 215                 220                 


His Ile Tyr Gly Lys Leu Leu Lys Thr Thr Val Thr Pro Glu Gly Glu 
225                 230                 235                 240 


Thr Ile Ile Leu Asp Gln Ile Asn Ile Asn Phe Val Val Asp Ala Gly 
                245                 250                 255     


Asn Glu Asn Leu Phe Phe Ile Ser Pro Leu Thr Ile Tyr His Val Ile 
            260                 265                 270         


Asp His Asn Ser Pro Phe Phe His Met Ala Ala Glu Thr Leu Leu Gln 
        275                 280                 285             


Gln Asp Phe Glu Leu Val Val Phe Leu Asp Gly Thr Val Glu Ser Thr 
    290                 295                 300                 


Ser Ala Thr Cys Gln Val Arg Thr Ser Tyr Val Pro Glu Glu Val Leu 
305                 310                 315                 320 


Trp Gly Tyr Arg Phe Ala Pro Ile Val Ser Lys Thr Lys Glu Gly Lys 
                325                 330                 335     


Tyr Arg Val Asp Phe His Asn Phe Ser Lys Thr Val Glu Val Glu Thr 
            340                 345                 350         


Pro His Cys Ala Met Cys Leu Tyr Asn Glu Lys Asp Val Arg Ala Arg 
        355                 360                 365             


Met Lys Arg Gly Tyr Asp Asn Pro Asn Phe Ile Leu Ser Glu Val Asn 
    370                 375                 380                 


Glu Thr Asp Asp Thr Lys Met 
385                 390     


<210>  70
<211>  976
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Arg Gly Ala Arg Gly Ala Trp Asp Phe Leu Cys Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Arg Val Gln Thr Gly Ser Ser Gln Pro Ser Val Ser Pro Gly 
            20                  25                  30          


Glu Pro Ser Pro Pro Ser Ile His Pro Gly Lys Ser Asp Leu Ile Val 
        35                  40                  45              


Arg Val Gly Asp Glu Ile Arg Leu Leu Cys Thr Asp Pro Gly Phe Val 
    50                  55                  60                  


Lys Trp Thr Phe Glu Ile Leu Asp Glu Thr Asn Glu Asn Lys Gln Asn 
65                  70                  75                  80  


Glu Trp Ile Thr Glu Lys Ala Glu Ala Thr Asn Thr Gly Lys Tyr Thr 
                85                  90                  95      


Cys Thr Asn Lys His Gly Leu Ser Asn Ser Ile Tyr Val Phe Val Arg 
            100                 105                 110         


Asp Pro Ala Lys Leu Phe Leu Val Asp Arg Ser Leu Tyr Gly Lys Glu 
        115                 120                 125             


Asp Asn Asp Thr Leu Val Arg Cys Pro Leu Thr Asp Pro Glu Val Thr 
    130                 135                 140                 


Asn Tyr Ser Leu Lys Gly Cys Gln Gly Lys Pro Leu Pro Lys Asp Leu 
145                 150                 155                 160 


Arg Phe Ile Pro Asp Pro Lys Ala Gly Ile Met Ile Lys Ser Val Lys 
                165                 170                 175     


Arg Ala Tyr His Arg Leu Cys Leu His Cys Ser Val Asp Gln Glu Gly 
            180                 185                 190         


Lys Ser Val Leu Ser Glu Lys Phe Ile Leu Lys Val Arg Pro Ala Phe 
        195                 200                 205             


Lys Ala Val Pro Val Val Ser Val Ser Lys Ala Ser Tyr Leu Leu Arg 
    210                 215                 220                 


Glu Gly Glu Glu Phe Thr Val Thr Cys Thr Ile Lys Asp Val Ser Ser 
225                 230                 235                 240 


Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn Ser Gln Thr Lys Leu Gln 
                245                 250                 255     


Glu Lys Tyr Asn Ser Trp His His Gly Asp Phe Asn Tyr Glu Arg Gln 
            260                 265                 270         


Ala Thr Leu Thr Ile Ser Ser Ala Arg Val Asn Asp Ser Gly Val Phe 
        275                 280                 285             


Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn Val Thr Thr Thr 
    290                 295                 300                 


Leu Glu Val Val Asp Lys Gly Phe Ile Asn Ile Phe Pro Met Ile Asn 
305                 310                 315                 320 


Thr Thr Val Phe Val Asn Asp Gly Glu Asn Val Asp Leu Ile Val Glu 
                325                 330                 335     


Tyr Glu Ala Phe Pro Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn 
            340                 345                 350         


Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu 
        355                 360                 365             


Ser Asn Ile Arg Tyr Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly 
    370                 375                 380                 


Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp Val Asn 
385                 390                 395                 400 


Ala Ala Ile Ala Phe Asn Val Tyr Val Asn Thr Lys Pro Glu Ile Leu 
                405                 410                 415     


Thr Tyr Asp Arg Leu Val Asn Gly Met Leu Gln Cys Val Ala Ala Gly 
            420                 425                 430         


Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe Cys Pro Gly Thr Glu Gln 
        435                 440                 445             


Arg Cys Ser Ala Ser Val Leu Pro Val Asp Val Gln Thr Leu Asn Ser 
    450                 455                 460                 


Ser Gly Pro Pro Phe Gly Lys Leu Val Val Gln Ser Ser Ile Asp Ser 
465                 470                 475                 480 


Ser Ala Phe Lys His Asn Gly Thr Val Glu Cys Lys Ala Tyr Asn Asp 
                485                 490                 495     


Val Gly Lys Thr Ser Ala Tyr Phe Asn Phe Ala Phe Lys Gly Asn Asn 
            500                 505                 510         


Lys Glu Gln Ile His Pro His Thr Leu Phe Thr Pro Leu Leu Ile Gly 
        515                 520                 525             


Phe Val Ile Val Ala Gly Met Met Cys Ile Ile Val Met Ile Leu Thr 
    530                 535                 540                 


Tyr Lys Tyr Leu Gln Lys Pro Met Tyr Glu Val Gln Trp Lys Val Val 
545                 550                 555                 560 


Glu Glu Ile Asn Gly Asn Asn Tyr Val Tyr Ile Asp Pro Thr Gln Leu 
                565                 570                 575     


Pro Tyr Asp His Lys Trp Glu Phe Pro Arg Asn Arg Leu Ser Phe Gly 
            580                 585                 590         


Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val Val Glu Ala Thr Ala 
        595                 600                 605             


Tyr Gly Leu Ile Lys Ser Asp Ala Ala Met Thr Val Ala Val Lys Met 
    610                 615                 620                 


Leu Lys Pro Ser Ala His Leu Thr Glu Arg Glu Ala Leu Met Ser Glu 
625                 630                 635                 640 


Leu Lys Val Leu Ser Tyr Leu Gly Asn His Met Asn Ile Val Asn Leu 
                645                 650                 655     


Leu Gly Ala Cys Thr Ile Gly Gly Pro Thr Leu Val Ile Thr Glu Tyr 
            660                 665                 670         


Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg Arg Lys Arg Asp Ser 
        675                 680                 685             


Phe Ile Cys Ser Lys Gln Glu Asp His Ala Glu Ala Ala Leu Tyr Lys 
    690                 695                 700                 


Asn Leu Leu His Ser Lys Glu Ser Ser Cys Ser Asp Ser Thr Asn Glu 
705                 710                 715                 720 


Tyr Met Asp Met Lys Pro Gly Val Ser Tyr Val Val Pro Thr Lys Ala 
                725                 730                 735     


Asp Lys Arg Arg Ser Val Arg Ile Gly Ser Tyr Ile Glu Arg Asp Val 
            740                 745                 750         


Thr Pro Ala Ile Met Glu Asp Asp Glu Leu Ala Leu Asp Leu Glu Asp 
        755                 760                 765             


Leu Leu Ser Phe Ser Tyr Gln Val Ala Lys Gly Met Ala Phe Leu Ala 
    770                 775                 780                 


Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu 
785                 790                 795                 800 


Thr His Gly Arg Ile Thr Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp 
                805                 810                 815     


Ile Lys Asn Asp Ser Asn Tyr Val Val Lys Gly Asn Ala Arg Leu Pro 
            820                 825                 830         


Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Cys Val Tyr Thr Phe 
        835                 840                 845             


Glu Ser Asp Val Trp Ser Tyr Gly Ile Phe Leu Trp Glu Leu Phe Ser 
    850                 855                 860                 


Leu Gly Ser Ser Pro Tyr Pro Gly Met Pro Val Asp Ser Lys Phe Tyr 
865                 870                 875                 880 


Lys Met Ile Lys Glu Gly Phe Arg Met Leu Ser Pro Glu His Ala Pro 
                885                 890                 895     


Ala Glu Met Tyr Asp Ile Met Lys Thr Cys Trp Asp Ala Asp Pro Leu 
            900                 905                 910         


Lys Arg Pro Thr Phe Lys Gln Ile Val Gln Leu Ile Glu Lys Gln Ile 
        915                 920                 925             


Ser Glu Ser Thr Asn His Ile Tyr Ser Asn Leu Ala Asn Cys Ser Pro 
    930                 935                 940                 


Asn Arg Gln Lys Pro Val Val Asp His Ser Val Arg Ile Asn Ser Val 
945                 950                 955                 960 


Gly Ser Thr Ala Ser Ser Ser Gln Pro Leu Leu Val His Asp Asp Val 
                965                 970                 975     


<210>  71
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Gly Pro Pro Gly Ser Pro Trp Gln Trp Val Thr Leu Leu Leu Gly 
1               5                   10                  15      


Leu Leu Leu Pro Pro Ala Ala Pro Phe Trp Leu Leu Asn Val Leu Phe 
            20                  25                  30          


Pro Pro His Thr Thr Pro Lys Ala Glu Leu Ser Asn His Thr Arg Pro 
        35                  40                  45              


Val Ile Leu Val Pro Gly Cys Leu Gly Asn Gln Leu Glu Ala Lys Leu 
    50                  55                  60                  


Asp Lys Pro Asp Val Val Asn Trp Met Cys Tyr Arg Lys Thr Glu Asp 
65                  70                  75                  80  


Phe Phe Thr Ile Trp Leu Asp Leu Asn Met Phe Leu Pro Leu Gly Val 
                85                  90                  95      


Asp Cys Trp Ile Asp Asn Thr Arg Val Val Tyr Asn Arg Ser Ser Gly 
            100                 105                 110         


Leu Val Ser Asn Ala Pro Gly Val Gln Ile Arg Val Pro Gly Phe Gly 
        115                 120                 125             


Lys Thr Tyr Ser Val Glu Tyr Leu Asp Ser Ser Lys Leu Ala Gly Tyr 
    130                 135                 140                 


Leu His Thr Leu Val Gln Asn Leu Val Asn Asn Gly Tyr Val Arg Asp 
145                 150                 155                 160 


Glu Thr Val Arg Ala Ala Pro Tyr Asp Trp Arg Leu Glu Pro Gly Gln 
                165                 170                 175     


Gln Glu Glu Tyr Tyr Arg Lys Leu Ala Gly Leu Val Glu Glu Met His 
            180                 185                 190         


Ala Ala Tyr Gly Lys Pro Val Phe Leu Ile Gly His Ser Leu Gly Cys 
        195                 200                 205             


Leu His Leu Leu Tyr Phe Leu Leu Arg Gln Pro Gln Ala Trp Lys Asp 
    210                 215                 220                 


Arg Phe Ile Asp Gly Phe Ile Ser Leu Gly Ala Pro Trp Gly Gly Ser 
225                 230                 235                 240 


Ile Lys Pro Met Leu Val Leu Ala Ser Gly Asp Asn Gln Gly Ile Pro 
                245                 250                 255     


Ile Met Ser Ser Ile Lys Leu Lys Glu Glu Gln Arg Ile Thr Thr Thr 
            260                 265                 270         


Ser Pro Trp Met Phe Pro Ser Arg Met Ala Trp Pro Glu Asp His Val 
        275                 280                 285             


Phe Ile Ser Thr Pro Ser Phe Asn Tyr Thr Gly Arg Asp Phe Gln Arg 
    290                 295                 300                 


Phe Phe Ala Asp Leu His Phe Glu Glu Gly Trp Tyr Met Trp Leu Gln 
305                 310                 315                 320 


Ser Arg Asp Leu Leu Ala Gly Leu Pro Ala Pro Gly Val Glu Val Tyr 
                325                 330                 335     


Cys Leu Tyr Gly Val Gly Leu Pro Thr Pro Arg Thr Tyr Ile Tyr Asp 
            340                 345                 350         


His Gly Phe Pro Tyr Thr Asp Pro Val Gly Val Leu Tyr Glu Asp Gly 
        355                 360                 365             


Asp Asp Thr Val Ala Thr Arg Ser Thr Glu Leu Cys Gly Leu Trp Gln 
    370                 375                 380                 


Gly Arg Gln Pro Gln Pro Val His Leu Leu Pro Leu His Gly Ile Gln 
385                 390                 395                 400 


His Leu Asn Met Val Phe Ser Asn Leu Thr Leu Glu His Ile Asn Ala 
                405                 410                 415     


Ile Leu Leu Gly Ala Tyr Arg Gln Gly Pro Pro Ala Ser Pro Thr Ala 
            420                 425                 430         


Ser Pro Glu Pro Pro Pro Pro Glu 
        435                 440 


<210>  72
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Val Arg Glu Gln Tyr Thr Thr Ala Thr Glu Gly Ile Cys Ile Glu 
1               5                   10                  15      


Arg Pro Glu Asn Gln Tyr Val Tyr Lys Ile Gly Ile Tyr Gly Trp Arg 
            20                  25                  30          


Lys Arg Cys Leu Tyr Leu Phe Val Leu Leu Leu Leu Ile Ile Leu Val 
        35                  40                  45              


Val Asn Leu Ala Leu Thr Ile Trp Ile Leu Lys Val Met Trp Phe Ser 
    50                  55                  60                  


Pro Ala Gly Met Gly His Leu Cys Val Thr Lys Asp Gly Leu Arg Leu 
65                  70                  75                  80  


Glu Gly Glu Ser Glu Phe Leu Phe Pro Leu Tyr Ala Lys Glu Ile His 
                85                  90                  95      


Ser Arg Val Asp Ser Ser Leu Leu Leu Gln Ser Thr Gln Asn Val Thr 
            100                 105                 110         


Val Asn Ala Arg Asn Ser Glu Gly Glu Val Thr Gly Arg Leu Lys Val 
        115                 120                 125             


Gly Pro Lys Met Val Glu Val Gln Asn Gln Gln Phe Gln Ile Asn Ser 
    130                 135                 140                 


Asn Asp Gly Lys Pro Leu Phe Thr Val Asp Glu Lys Glu Val Val Val 
145                 150                 155                 160 


Gly Thr Asp Lys Leu Arg Val Thr Gly Pro Glu Gly Ala Leu Phe Glu 
                165                 170                 175     


His Ser Val Glu Thr Pro Leu Val Arg Ala Asp Pro Phe Gln Asp Leu 
            180                 185                 190         


Arg Leu Glu Ser Pro Thr Arg Ser Leu Ser Met Asp Ala Pro Arg Gly 
        195                 200                 205             


Val His Ile Gln Ala His Ala Gly Lys Ile Glu Ala Leu Ser Gln Met 
    210                 215                 220                 


Asp Ile Leu Phe His Ser Ser Asp Gly Met Leu Val Leu Asp Ala Glu 
225                 230                 235                 240 


Thr Val Cys Leu Pro Lys Leu Val Gln Gly Thr Trp Gly Pro Ser Gly 
                245                 250                 255     


Ser Ser Gln Ser Leu Tyr Glu Ile Cys Val Cys Pro Asp Gly Lys Leu 
            260                 265                 270         


Tyr Leu Ser Val Ala Gly Val Ser Thr Thr Cys Gln Glu His Ser His 
        275                 280                 285             


Ile Cys Leu 
    290     


<210>  73
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Ala Ala Ala Ala Ala Ala Ala Ala Glu Gln Gln Ser Ser Asn Gly 
1               5                   10                  15      


Pro Val Lys Lys Ser Met Arg Glu Lys Ala Val Glu Arg Arg Ser Val 
            20                  25                  30          


Asn Lys Glu His Asn Ser Asn Phe Lys Ala Gly Tyr Ile Pro Ile Asp 
        35                  40                  45              


Glu Asp Arg Leu His Lys Thr Gly Leu Arg Gly Arg Lys Gly Asn Leu 
    50                  55                  60                  


Ala Ile Cys Val Ile Ile Leu Leu Phe Ile Leu Ala Val Ile Asn Leu 
65                  70                  75                  80  


Ile Ile Thr Leu Val Ile Trp Ala Val Ile Arg Ile Gly Pro Asn Gly 
                85                  90                  95      


Cys Asp Ser Met Glu Phe His Glu Ser Gly Leu Leu Arg Phe Lys Gln 
            100                 105                 110         


Val Ser Asp Met Gly Val Ile His Pro Leu Tyr Lys Ser Thr Val Gly 
        115                 120                 125             


Gly Arg Arg Asn Glu Asn Leu Val Ile Thr Gly Asn Asn Gln Pro Ile 
    130                 135                 140                 


Val Phe Gln Gln Gly Thr Thr Lys Leu Ser Val Glu Asn Asn Lys Thr 
145                 150                 155                 160 


Ser Ile Thr Ser Asp Ile Gly Met Gln Phe Phe Asp Pro Arg Thr Gln 
                165                 170                 175     


Asn Ile Leu Phe Ser Thr Asp Tyr Glu Thr His Glu Phe His Leu Pro 
            180                 185                 190         


Ser Gly Val Lys Ser Leu Asn Val Gln Lys Ala Ser Thr Glu Arg Ile 
        195                 200                 205             


Thr Ser Asn Ala Thr Ser Asp Leu Asn Ile Lys Val Asp Gly Arg Ala 
    210                 215                 220                 


Ile Val Arg Gly Asn Glu Gly Val Phe Ile Met Gly Lys Thr Ile Glu 
225                 230                 235                 240 


Phe His Met Gly Gly Asn Met Glu Leu Lys Ala Glu Asn Ser Ile Ile 
                245                 250                 255     


Leu Asn Gly Ser Val Met Val Ser Thr Thr Arg Leu Pro Ser Ser Ser 
            260                 265                 270         


Ser Gly Asp Gln Leu Gly Ser Gly Asp Trp Val Arg Tyr Lys Leu Cys 
        275                 280                 285             


Met Cys Ala Asp Gly Thr Leu Phe Lys Val Gln Val Thr Ser Gln Asn 
    290                 295                 300                 


Met Gly Cys Gln Ile Ser Asp Asn Pro Cys Gly Asn Thr His 
305                 310                 315             


<210>  74
<211>  699
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Lys Gln Arg Phe Ser Ala Leu Gln Leu Leu Lys Leu Leu Leu Leu 
1               5                   10                  15      


Leu Gln Pro Pro Leu Pro Arg Ala Leu Arg Glu Ala Leu Cys Pro Glu 
            20                  25                  30          


Pro Cys Asn Cys Val Pro Asp Gly Ala Leu Arg Cys Pro Gly Pro Thr 
        35                  40                  45              


Ala Gly Leu Thr Arg Leu Ser Leu Ala Tyr Leu Pro Val Lys Val Ile 
    50                  55                  60                  


Pro Ser Gln Ala Phe Arg Gly Leu Asn Glu Val Ile Lys Ile Glu Ile 
65                  70                  75                  80  


Ser Gln Ile Asp Ser Leu Glu Arg Ile Glu Ala Asn Ala Phe Asp Asn 
                85                  90                  95      


Leu Leu Asn Leu Ser Glu Ile Leu Ile Gln Asn Thr Lys Asn Leu Arg 
            100                 105                 110         


Tyr Ile Glu Pro Gly Ala Phe Ile Asn Leu Pro Arg Leu Lys Tyr Leu 
        115                 120                 125             


Ser Ile Cys Asn Thr Gly Ile Arg Lys Phe Pro Asp Val Thr Lys Val 
    130                 135                 140                 


Phe Ser Ser Glu Ser Asn Phe Ile Leu Glu Ile Cys Asp Asn Leu His 
145                 150                 155                 160 


Ile Thr Thr Ile Pro Gly Asn Ala Phe Gln Gly Met Asn Asn Glu Ser 
                165                 170                 175     


Val Thr Leu Lys Leu Tyr Gly Asn Gly Phe Glu Glu Val Gln Ser His 
            180                 185                 190         


Ala Phe Asn Gly Thr Thr Leu Thr Ser Leu Glu Leu Lys Glu Asn Val 
        195                 200                 205             


His Leu Glu Lys Met His Asn Gly Ala Phe Arg Gly Ala Thr Gly Pro 
    210                 215                 220                 


Lys Thr Leu Asp Ile Ser Ser Thr Lys Leu Gln Ala Leu Pro Ser Tyr 
225                 230                 235                 240 


Gly Leu Glu Ser Ile Gln Arg Leu Ile Ala Thr Ser Ser Tyr Ser Leu 
                245                 250                 255     


Lys Lys Leu Pro Ser Arg Glu Thr Phe Val Asn Leu Leu Glu Ala Thr 
            260                 265                 270         


Leu Thr Tyr Pro Ser His Cys Cys Ala Phe Arg Asn Leu Pro Thr Lys 
        275                 280                 285             


Glu Gln Asn Phe Ser His Ser Ile Ser Glu Asn Phe Ser Lys Gln Cys 
    290                 295                 300                 


Glu Ser Thr Val Arg Lys Val Asn Asn Lys Thr Leu Tyr Ser Ser Met 
305                 310                 315                 320 


Leu Ala Glu Ser Glu Leu Ser Gly Trp Asp Tyr Glu Tyr Gly Phe Cys 
                325                 330                 335     


Leu Pro Lys Thr Pro Arg Cys Ala Pro Glu Pro Asp Ala Phe Asn Pro 
            340                 345                 350         


Cys Glu Asp Ile Met Gly Tyr Asp Phe Leu Arg Val Leu Ile Trp Leu 
        355                 360                 365             


Ile Asn Ile Leu Ala Ile Met Gly Asn Met Thr Val Leu Phe Val Leu 
    370                 375                 380                 


Leu Thr Ser Arg Tyr Lys Leu Thr Val Pro Arg Phe Leu Met Cys Asn 
385                 390                 395                 400 


Leu Ser Phe Ala Asp Phe Cys Met Gly Leu Tyr Leu Leu Leu Ile Ala 
                405                 410                 415     


Ser Val Asp Ser Gln Thr Lys Gly Gln Tyr Tyr Asn His Ala Ile Asp 
            420                 425                 430         


Trp Gln Thr Gly Ser Gly Cys Ser Thr Ala Gly Phe Phe Thr Val Phe 
        435                 440                 445             


Ala Ser Glu Leu Ser Val Tyr Thr Leu Thr Val Ile Thr Leu Glu Arg 
    450                 455                 460                 


Trp His Thr Ile Thr Tyr Ala Ile His Leu Asp Gln Lys Leu Arg Leu 
465                 470                 475                 480 


Arg His Ala Ile Leu Ile Met Leu Gly Gly Trp Leu Phe Ser Ser Leu 
                485                 490                 495     


Ile Ala Met Leu Pro Leu Val Gly Val Ser Asn Tyr Met Lys Val Ser 
            500                 505                 510         


Ile Cys Phe Pro Met Asp Val Glu Thr Thr Leu Ser Gln Val Tyr Ile 
        515                 520                 525             


Leu Thr Ile Leu Ile Leu Asn Val Val Ala Phe Phe Ile Ile Cys Ala 
    530                 535                 540                 


Cys Tyr Ile Lys Ile Tyr Phe Ala Val Arg Asn Pro Glu Leu Met Ala 
545                 550                 555                 560 


Thr Asn Lys Asp Thr Lys Ile Ala Lys Lys Met Ala Ile Leu Ile Phe 
                565                 570                 575     


Thr Asp Phe Thr Cys Met Ala Pro Ile Ser Phe Phe Ala Ile Ser Ala 
            580                 585                 590         


Ala Phe Lys Val Pro Leu Ile Thr Val Thr Asn Ser Lys Val Leu Leu 
        595                 600                 605             


Val Leu Phe Tyr Pro Ile Asn Ser Cys Ala Asn Pro Phe Leu Tyr Ala 
    610                 615                 620                 


Ile Phe Thr Lys Thr Phe Gln Arg Asp Phe Phe Leu Leu Leu Ser Lys 
625                 630                 635                 640 


Phe Gly Cys Cys Lys Arg Arg Ala Glu Leu Tyr Arg Arg Lys Asp Phe 
                645                 650                 655     


Ser Ala Tyr Thr Ser Asn Cys Lys Asn Gly Phe Thr Gly Ser Asn Lys 
            660                 665                 670         


Pro Ser Gln Ser Thr Leu Lys Leu Ser Thr Leu His Cys Gln Gly Thr 
        675                 680                 685             


Ala Leu Leu Asp Lys Thr Arg Tyr Thr Glu Cys 
    690                 695                 


<210>  75
<211>  1159
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Pro Val Arg Arg Gly His Val Ala Pro Gln Asn Thr Phe Leu Asp 
1               5                   10                  15      


Thr Ile Ile Arg Lys Phe Glu Gly Gln Ser Arg Lys Phe Ile Ile Ala 
            20                  25                  30          


Asn Ala Arg Val Glu Asn Cys Ala Val Ile Tyr Cys Asn Asp Gly Phe 
        35                  40                  45              


Cys Glu Leu Cys Gly Tyr Ser Arg Ala Glu Val Met Gln Arg Pro Cys 
    50                  55                  60                  


Thr Cys Asp Phe Leu His Gly Pro Arg Thr Gln Arg Arg Ala Ala Ala 
65                  70                  75                  80  


Gln Ile Ala Gln Ala Leu Leu Gly Ala Glu Glu Arg Lys Val Glu Ile 
                85                  90                  95      


Ala Phe Tyr Arg Lys Asp Gly Ser Cys Phe Leu Cys Leu Val Asp Val 
            100                 105                 110         


Val Pro Val Lys Asn Glu Asp Gly Ala Val Ile Met Phe Ile Leu Asn 
        115                 120                 125             


Phe Glu Val Val Met Glu Lys Asp Met Val Gly Ser Pro Ala His Asp 
    130                 135                 140                 


Thr Asn His Arg Gly Pro Pro Thr Ser Trp Leu Ala Pro Gly Arg Ala 
145                 150                 155                 160 


Lys Thr Phe Arg Leu Lys Leu Pro Ala Leu Leu Ala Leu Thr Ala Arg 
                165                 170                 175     


Glu Ser Ser Val Arg Ser Gly Gly Ala Gly Gly Ala Gly Ala Pro Gly 
            180                 185                 190         


Ala Val Val Val Asp Val Asp Leu Thr Pro Ala Ala Pro Ser Ser Glu 
        195                 200                 205             


Ser Leu Ala Leu Asp Glu Val Thr Ala Met Asp Asn His Val Ala Gly 
    210                 215                 220                 


Leu Gly Pro Ala Glu Glu Arg Arg Ala Leu Val Gly Pro Gly Ser Pro 
225                 230                 235                 240 


Pro Arg Ser Ala Pro Gly Gln Leu Pro Ser Pro Arg Ala His Ser Leu 
                245                 250                 255     


Asn Pro Asp Ala Ser Gly Ser Ser Cys Ser Leu Ala Arg Thr Arg Ser 
            260                 265                 270         


Arg Glu Ser Cys Ala Ser Val Arg Arg Ala Ser Ser Ala Asp Asp Ile 
        275                 280                 285             


Glu Ala Met Arg Ala Gly Val Leu Pro Pro Pro Pro Arg His Ala Ser 
    290                 295                 300                 


Thr Gly Ala Met His Pro Leu Arg Ser Gly Leu Leu Asn Ser Thr Ser 
305                 310                 315                 320 


Asp Ser Asp Leu Val Arg Tyr Arg Thr Ile Ser Lys Ile Pro Gln Ile 
                325                 330                 335     


Thr Leu Asn Phe Val Asp Leu Lys Gly Asp Pro Phe Leu Ala Ser Pro 
            340                 345                 350         


Thr Ser Asp Arg Glu Ile Ile Ala Pro Lys Ile Lys Glu Arg Thr His 
        355                 360                 365             


Asn Val Thr Glu Lys Val Thr Gln Val Leu Ser Leu Gly Ala Asp Val 
    370                 375                 380                 


Leu Pro Glu Tyr Lys Leu Gln Ala Pro Arg Ile His Arg Trp Thr Ile 
385                 390                 395                 400 


Leu His Tyr Ser Pro Phe Lys Ala Val Trp Asp Trp Leu Ile Leu Leu 
                405                 410                 415     


Leu Val Ile Tyr Thr Ala Val Phe Thr Pro Tyr Ser Ala Ala Phe Leu 
            420                 425                 430         


Leu Lys Glu Thr Glu Glu Gly Pro Pro Ala Thr Glu Cys Gly Tyr Ala 
        435                 440                 445             


Cys Gln Pro Leu Ala Val Val Asp Leu Ile Val Asp Ile Met Phe Ile 
    450                 455                 460                 


Val Asp Ile Leu Ile Asn Phe Arg Thr Thr Tyr Val Asn Ala Asn Glu 
465                 470                 475                 480 


Glu Val Val Ser His Pro Gly Arg Ile Ala Val His Tyr Phe Lys Gly 
                485                 490                 495     


Trp Phe Leu Ile Asp Met Val Ala Ala Ile Pro Phe Asp Leu Leu Ile 
            500                 505                 510         


Phe Gly Ser Gly Ser Glu Glu Leu Ile Gly Leu Leu Lys Thr Ala Arg 
        515                 520                 525             


Leu Leu Arg Leu Val Arg Val Ala Arg Lys Leu Asp Arg Tyr Ser Glu 
    530                 535                 540                 


Tyr Gly Ala Ala Val Leu Phe Leu Leu Met Cys Thr Phe Ala Leu Ile 
545                 550                 555                 560 


Ala His Trp Leu Ala Cys Ile Trp Tyr Ala Ile Gly Asn Met Glu Gln 
                565                 570                 575     


Pro His Met Asp Ser Arg Ile Gly Trp Leu His Asn Leu Gly Asp Gln 
            580                 585                 590         


Ile Gly Lys Pro Tyr Asn Ser Ser Gly Leu Gly Gly Pro Ser Ile Lys 
        595                 600                 605             


Asp Lys Tyr Val Thr Ala Leu Tyr Phe Thr Phe Ser Ser Leu Thr Ser 
    610                 615                 620                 


Val Gly Phe Gly Asn Val Ser Pro Asn Thr Asn Ser Glu Lys Ile Phe 
625                 630                 635                 640 


Ser Ile Cys Val Met Leu Ile Gly Ser Leu Met Tyr Ala Ser Ile Phe 
                645                 650                 655     


Gly Asn Val Ser Ala Ile Ile Gln Arg Leu Tyr Ser Gly Thr Ala Arg 
            660                 665                 670         


Tyr His Thr Gln Met Leu Arg Val Arg Glu Phe Ile Arg Phe His Gln 
        675                 680                 685             


Ile Pro Asn Pro Leu Arg Gln Arg Leu Glu Glu Tyr Phe Gln His Ala 
    690                 695                 700                 


Trp Ser Tyr Thr Asn Gly Ile Asp Met Asn Ala Val Leu Lys Gly Phe 
705                 710                 715                 720 


Pro Glu Cys Leu Gln Ala Asp Ile Cys Leu His Leu Asn Arg Ser Leu 
                725                 730                 735     


Leu Gln His Cys Lys Pro Phe Arg Gly Ala Thr Lys Gly Cys Leu Arg 
            740                 745                 750         


Ala Leu Ala Met Lys Phe Lys Thr Thr His Ala Pro Pro Gly Asp Thr 
        755                 760                 765             


Leu Val His Ala Gly Asp Leu Leu Thr Ala Leu Tyr Phe Ile Ser Arg 
    770                 775                 780                 


Gly Ser Ile Glu Ile Leu Arg Gly Asp Val Val Val Ala Ile Leu Gly 
785                 790                 795                 800 


Lys Asn Asp Ile Phe Gly Glu Pro Leu Asn Leu Tyr Ala Arg Pro Gly 
                805                 810                 815     


Lys Ser Asn Gly Asp Val Arg Ala Leu Thr Tyr Cys Asp Leu His Lys 
            820                 825                 830         


Ile His Arg Asp Asp Leu Leu Glu Val Leu Asp Met Tyr Pro Glu Phe 
        835                 840                 845             


Ser Asp His Phe Trp Ser Ser Leu Glu Ile Thr Phe Asn Leu Arg Asp 
    850                 855                 860                 


Thr Asn Met Ile Pro Gly Ser Pro Gly Ser Thr Glu Leu Glu Gly Gly 
865                 870                 875                 880 


Phe Ser Arg Gln Arg Lys Arg Lys Leu Ser Phe Arg Arg Arg Thr Asp 
                885                 890                 895     


Lys Asp Thr Glu Gln Pro Gly Glu Val Ser Ala Leu Gly Pro Gly Arg 
            900                 905                 910         


Ala Gly Ala Gly Pro Ser Ser Arg Gly Arg Pro Gly Gly Pro Trp Gly 
        915                 920                 925             


Glu Ser Pro Ser Ser Gly Pro Ser Ser Pro Glu Ser Ser Glu Asp Glu 
    930                 935                 940                 


Gly Pro Gly Arg Ser Ser Ser Pro Leu Arg Leu Val Pro Phe Ser Ser 
945                 950                 955                 960 


Pro Arg Pro Pro Gly Glu Pro Pro Gly Gly Glu Pro Leu Met Glu Asp 
                965                 970                 975     


Cys Glu Lys Ser Ser Asp Thr Cys Asn Pro Leu Ser Gly Ala Phe Ser 
            980                 985                 990         


Gly Val Ser Asn Ile Phe Ser Phe  Trp Gly Asp Ser Arg  Gly Arg Gln 
        995                 1000                 1005             


Tyr Gln  Glu Leu Pro Arg Cys  Pro Ala Pro Thr Pro  Ser Leu Leu 
    1010                 1015                 1020             


Asn Ile  Pro Leu Ser Ser Pro  Gly Arg Arg Pro Arg  Gly Asp Val 
    1025                 1030                 1035             


Glu Ser  Arg Leu Asp Ala Leu  Gln Arg Gln Leu Asn  Arg Leu Glu 
    1040                 1045                 1050             


Thr Arg  Leu Ser Ala Asp Met  Ala Thr Val Leu Gln  Leu Leu Gln 
    1055                 1060                 1065             


Arg Gln  Met Thr Leu Val Pro  Pro Ala Tyr Ser Ala  Val Thr Thr 
    1070                 1075                 1080             


Pro Gly  Pro Gly Pro Thr Ser  Thr Ser Pro Leu Leu  Pro Val Ser 
    1085                 1090                 1095             


Pro Leu  Pro Thr Leu Thr Leu  Asp Ser Leu Ser Gln  Val Ser Gln 
    1100                 1105                 1110             


Phe Met  Ala Cys Glu Glu Leu  Pro Pro Gly Ala Pro  Glu Leu Pro 
    1115                 1120                 1125             


Gln Glu  Gly Pro Thr Arg Arg  Leu Ser Leu Pro Gly  Gln Leu Gly 
    1130                 1135                 1140             


Ala Leu  Thr Ser Gln Pro Leu  His Arg His Gly Ser  Asp Pro Gly 
    1145                 1150                 1155             


Ser 
    


<210>  76
<211>  1390
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe 
1               5                   10                  15      


Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys 
            20                  25                  30          


Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala 
        35                  40                  45              


Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu 
    50                  55                  60                  


Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys 
65                  70                  75                  80  


Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe 
                85                  90                  95      


Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp 
            100                 105                 110         


Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp 
        115                 120                 125             


Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His 
    130                 135                 140                 


Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys 
145                 150                 155                 160 


Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val 
                165                 170                 175     


Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe 
            180                 185                 190         


Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp 
        195                 200                 205             


His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp 
    210                 215                 220                 


Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu 
225                 230                 235                 240 


Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn 
                245                 250                 255     


Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln 
            260                 265                 270         


Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu 
        275                 280                 285             


His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg 
    290                 295                 300                 


Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala 
305                 310                 315                 320 


Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser 
                325                 330                 335     


Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp 
            340                 345                 350         


Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys 
        355                 360                 365             


Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg 
    370                 375                 380                 


Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg 
385                 390                 395                 400 


Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr 
                405                 410                 415     


Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly 
            420                 425                 430         


Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly 
        435                 440                 445             


Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln 
    450                 455                 460                 


Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu 
465                 470                 475                 480 


Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu 
                485                 490                 495     


Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys 
            500                 505                 510         


Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln 
        515                 520                 525             


Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys 
    530                 535                 540                 


Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile 
545                 550                 555                 560 


Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu 
                565                 570                 575     


Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg 
            580                 585                 590         


Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu 
        595                 600                 605             


Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys 
    610                 615                 620                 


Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile 
625                 630                 635                 640 


Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp 
                645                 650                 655     


Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly 
            660                 665                 670         


Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg 
        675                 680                 685             


His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn 
    690                 695                 700                 


Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe 
705                 710                 715                 720 


Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe 
                725                 730                 735     


Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser 
            740                 745                 750         


Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn Leu Asn 
        755                 760                 765             


Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala Gly Arg 
    770                 775                 780                 


Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile Ile Cys 
785                 790                 795                 800 


Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro Leu Lys 
                805                 810                 815     


Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr Phe Asp 
            820                 825                 830         


Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys Pro Val 
        835                 840                 845             


Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly Asn Asp 
    850                 855                 860                 


Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn Lys 
865                 870                 875                 880 


Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys Thr Val 
                885                 890                 895     


Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu Trp Lys 
            900                 905                 910         


Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln Pro Asp 
        915                 920                 925             


Gln Asn Phe Thr Gly Leu Ile Ala Gly Val Val Ser Ile Ser Thr Ala 
    930                 935                 940                 


Leu Leu Leu Leu Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg Lys Gln 
945                 950                 955                 960 


Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg Val His 
                965                 970                 975     


Thr Pro His Leu Asp Arg Leu Val Ser Ala Arg Ser Val Ser Pro Thr 
            980                 985                 990         


Thr Glu Met Val Ser Asn Glu Ser  Val Asp Tyr Arg Ala  Thr Phe Pro 
        995                 1000                 1005             


Glu Asp  Gln Phe Pro Asn Ser  Ser Gln Asn Gly Ser  Cys Arg Gln 
    1010                 1015                 1020             


Val Gln  Tyr Pro Leu Thr Asp  Met Ser Pro Ile Leu  Thr Ser Gly 
    1025                 1030                 1035             


Asp Ser  Asp Ile Ser Ser Pro  Leu Leu Gln Asn Thr  Val His Ile 
    1040                 1045                 1050             


Asp Leu  Ser Ala Leu Asn Pro  Glu Leu Val Gln Ala  Val Gln His 
    1055                 1060                 1065             


Val Val  Ile Gly Pro Ser Ser  Leu Ile Val His Phe  Asn Glu Val 
    1070                 1075                 1080             


Ile Gly  Arg Gly His Phe Gly  Cys Val Tyr His Gly  Thr Leu Leu 
    1085                 1090                 1095             


Asp Asn  Asp Gly Lys Lys Ile  His Cys Ala Val Lys  Ser Leu Asn 
    1100                 1105                 1110             


Arg Ile  Thr Asp Ile Gly Glu  Val Ser Gln Phe Leu  Thr Glu Gly 
    1115                 1120                 1125             


Ile Ile  Met Lys Asp Phe Ser  His Pro Asn Val Leu  Ser Leu Leu 
    1130                 1135                 1140             


Gly Ile  Cys Leu Arg Ser Glu  Gly Ser Pro Leu Val  Val Leu Pro 
    1145                 1150                 1155             


Tyr Met  Lys His Gly Asp Leu  Arg Asn Phe Ile Arg  Asn Glu Thr 
    1160                 1165                 1170             


His Asn  Pro Thr Val Lys Asp  Leu Ile Gly Phe Gly  Leu Gln Val 
    1175                 1180                 1185             


Ala Lys  Gly Met Lys Tyr Leu  Ala Ser Lys Lys Phe  Val His Arg 
    1190                 1195                 1200             


Asp Leu  Ala Ala Arg Asn Cys  Met Leu Asp Glu Lys  Phe Thr Val 
    1205                 1210                 1215             


Lys Val  Ala Asp Phe Gly Leu  Ala Arg Asp Met Tyr  Asp Lys Glu 
    1220                 1225                 1230             


Tyr Tyr  Ser Val His Asn Lys  Thr Gly Ala Lys Leu  Pro Val Lys 
    1235                 1240                 1245             


Trp Met  Ala Leu Glu Ser Leu  Gln Thr Gln Lys Phe  Thr Thr Lys 
    1250                 1255                 1260             


Ser Asp  Val Trp Ser Phe Gly  Val Leu Leu Trp Glu  Leu Met Thr 
    1265                 1270                 1275             


Arg Gly  Ala Pro Pro Tyr Pro  Asp Val Asn Thr Phe  Asp Ile Thr 
    1280                 1285                 1290             


Val Tyr  Leu Leu Gln Gly Arg  Arg Leu Leu Gln Pro  Glu Tyr Cys 
    1295                 1300                 1305             


Pro Asp  Pro Leu Tyr Glu Val  Met Leu Lys Cys Trp  His Pro Lys 
    1310                 1315                 1320             


Ala Glu  Met Arg Pro Ser Phe  Ser Glu Leu Val Ser  Arg Ile Ser 
    1325                 1330                 1335             


Ala Ile  Phe Ser Thr Phe Ile  Gly Glu His Tyr Val  His Val Asn 
    1340                 1345                 1350             


Ala Thr  Tyr Val Asn Val Lys  Cys Val Ala Pro Tyr  Pro Ser Leu 
    1355                 1360                 1365             


Leu Ser  Ser Glu Asp Asn Ala  Asp Asp Glu Val Asp  Thr Arg Pro 
    1370                 1375                 1380             


Ala Ser  Phe Trp Glu Thr Ser  
    1385                 1390 


<210>  77
<211>  1447
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Ala Ser Ala Gly Asn Ala Ala Glu Pro Gln Asp Arg Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Cys Ile Gly Ala Pro Gly Arg Pro Ala Gly Gly Gly Arg 
            20                  25                  30          


Arg Arg Arg Thr Gly Gly Leu Arg Arg Ala Ala Ala Pro Asp Arg Asp 
        35                  40                  45              


Tyr Leu His Arg Pro Ser Tyr Cys Asp Ala Ala Phe Ala Leu Glu Gln 
    50                  55                  60                  


Ile Ser Lys Gly Lys Ala Thr Gly Arg Lys Ala Pro Leu Trp Leu Arg 
65                  70                  75                  80  


Ala Lys Phe Gln Arg Leu Leu Phe Lys Leu Gly Cys Tyr Ile Gln Lys 
                85                  90                  95      


Asn Cys Gly Lys Phe Leu Val Val Gly Leu Leu Ile Phe Gly Ala Phe 
            100                 105                 110         


Ala Val Gly Leu Lys Ala Ala Asn Leu Glu Thr Asn Val Glu Glu Leu 
        115                 120                 125             


Trp Val Glu Val Gly Gly Arg Val Ser Arg Glu Leu Asn Tyr Thr Arg 
    130                 135                 140                 


Gln Lys Ile Gly Glu Glu Ala Met Phe Asn Pro Gln Leu Met Ile Gln 
145                 150                 155                 160 


Thr Pro Lys Glu Glu Gly Ala Asn Val Leu Thr Thr Glu Ala Leu Leu 
                165                 170                 175     


Gln His Leu Asp Ser Ala Leu Gln Ala Ser Arg Val His Val Tyr Met 
            180                 185                 190         


Tyr Asn Arg Gln Trp Lys Leu Glu His Leu Cys Tyr Lys Ser Gly Glu 
        195                 200                 205             


Leu Ile Thr Glu Thr Gly Tyr Met Asp Gln Ile Ile Glu Tyr Leu Tyr 
    210                 215                 220                 


Pro Cys Leu Ile Ile Thr Pro Leu Asp Cys Phe Trp Glu Gly Ala Lys 
225                 230                 235                 240 


Leu Gln Ser Gly Thr Ala Tyr Leu Leu Gly Lys Pro Pro Leu Arg Trp 
                245                 250                 255     


Thr Asn Phe Asp Pro Leu Glu Phe Leu Glu Glu Leu Lys Lys Ile Asn 
            260                 265                 270         


Tyr Gln Val Asp Ser Trp Glu Glu Met Leu Asn Lys Ala Glu Val Gly 
        275                 280                 285             


His Gly Tyr Met Asp Arg Pro Cys Leu Asn Pro Ala Asp Pro Asp Cys 
    290                 295                 300                 


Pro Ala Thr Ala Pro Asn Lys Asn Ser Thr Lys Pro Leu Asp Met Ala 
305                 310                 315                 320 


Leu Val Leu Asn Gly Gly Cys His Gly Leu Ser Arg Lys Tyr Met His 
                325                 330                 335     


Trp Gln Glu Glu Leu Ile Val Gly Gly Thr Val Lys Asn Ser Thr Gly 
            340                 345                 350         


Lys Leu Val Ser Ala His Ala Leu Gln Thr Met Phe Gln Leu Met Thr 
        355                 360                 365             


Pro Lys Gln Met Tyr Glu His Phe Lys Gly Tyr Glu Tyr Val Ser His 
    370                 375                 380                 


Ile Asn Trp Asn Glu Asp Lys Ala Ala Ala Ile Leu Glu Ala Trp Gln 
385                 390                 395                 400 


Arg Thr Tyr Val Glu Val Val His Gln Ser Val Ala Gln Asn Ser Thr 
                405                 410                 415     


Gln Lys Val Leu Ser Phe Thr Thr Thr Thr Leu Asp Asp Ile Leu Lys 
            420                 425                 430         


Ser Phe Ser Asp Val Ser Val Ile Arg Val Ala Ser Gly Tyr Leu Leu 
        435                 440                 445             


Met Leu Ala Tyr Ala Cys Leu Thr Met Leu Arg Trp Asp Cys Ser Lys 
    450                 455                 460                 


Ser Gln Gly Ala Val Gly Leu Ala Gly Val Leu Leu Val Ala Leu Ser 
465                 470                 475                 480 


Val Ala Ala Gly Leu Gly Leu Cys Ser Leu Ile Gly Ile Ser Phe Asn 
                485                 490                 495     


Ala Ala Thr Thr Gln Val Leu Pro Phe Leu Ala Leu Gly Val Gly Val 
            500                 505                 510         


Asp Asp Val Phe Leu Leu Ala His Ala Phe Ser Glu Thr Gly Gln Asn 
        515                 520                 525             


Lys Arg Ile Pro Phe Glu Asp Arg Thr Gly Glu Cys Leu Lys Arg Thr 
    530                 535                 540                 


Gly Ala Ser Val Ala Leu Thr Ser Ile Ser Asn Val Thr Ala Phe Phe 
545                 550                 555                 560 


Met Ala Ala Leu Ile Pro Ile Pro Ala Leu Arg Ala Phe Ser Leu Gln 
                565                 570                 575     


Ala Ala Val Val Val Val Phe Asn Phe Ala Met Val Leu Leu Ile Phe 
            580                 585                 590         


Pro Ala Ile Leu Ser Met Asp Leu Tyr Arg Arg Glu Asp Arg Arg Leu 
        595                 600                 605             


Asp Ile Phe Cys Cys Phe Thr Ser Pro Cys Val Ser Arg Val Ile Gln 
    610                 615                 620                 


Val Glu Pro Gln Ala Tyr Thr Asp Thr His Asp Asn Thr Arg Tyr Ser 
625                 630                 635                 640 


Pro Pro Pro Pro Tyr Ser Ser His Ser Phe Ala His Glu Thr Gln Ile 
                645                 650                 655     


Thr Met Gln Ser Thr Val Gln Leu Arg Thr Glu Tyr Asp Pro His Thr 
            660                 665                 670         


His Val Tyr Tyr Thr Thr Ala Glu Pro Arg Ser Glu Ile Ser Val Gln 
        675                 680                 685             


Pro Val Thr Val Thr Gln Asp Thr Leu Ser Cys Gln Ser Pro Glu Ser 
    690                 695                 700                 


Thr Ser Ser Thr Arg Asp Leu Leu Ser Gln Phe Ser Asp Ser Ser Leu 
705                 710                 715                 720 


His Cys Leu Glu Pro Pro Cys Thr Lys Trp Thr Leu Ser Ser Phe Ala 
                725                 730                 735     


Glu Lys His Tyr Ala Pro Phe Leu Leu Lys Pro Lys Ala Lys Val Val 
            740                 745                 750         


Val Ile Phe Leu Phe Leu Gly Leu Leu Gly Val Ser Leu Tyr Gly Thr 
        755                 760                 765             


Thr Arg Val Arg Asp Gly Leu Asp Leu Thr Asp Ile Val Pro Arg Glu 
    770                 775                 780                 


Thr Arg Glu Tyr Asp Phe Ile Ala Ala Gln Phe Lys Tyr Phe Ser Phe 
785                 790                 795                 800 


Tyr Asn Met Tyr Ile Val Thr Gln Lys Ala Asp Tyr Pro Asn Ile Gln 
                805                 810                 815     


His Leu Leu Tyr Asp Leu His Arg Ser Phe Ser Asn Val Lys Tyr Val 
            820                 825                 830         


Met Leu Glu Glu Asn Lys Gln Leu Pro Lys Met Trp Leu His Tyr Phe 
        835                 840                 845             


Arg Asp Trp Leu Gln Gly Leu Gln Asp Ala Phe Asp Ser Asp Trp Glu 
    850                 855                 860                 


Thr Gly Lys Ile Met Pro Asn Asn Tyr Lys Asn Gly Ser Asp Asp Gly 
865                 870                 875                 880 


Val Leu Ala Tyr Lys Leu Leu Val Gln Thr Gly Ser Arg Asp Lys Pro 
                885                 890                 895     


Ile Asp Ile Ser Gln Leu Thr Lys Gln Arg Leu Val Asp Ala Asp Gly 
            900                 905                 910         


Ile Ile Asn Pro Ser Ala Phe Tyr Ile Tyr Leu Thr Ala Trp Val Ser 
        915                 920                 925             


Asn Asp Pro Val Ala Tyr Ala Ala Ser Gln Ala Asn Ile Arg Pro His 
    930                 935                 940                 


Arg Pro Glu Trp Val His Asp Lys Ala Asp Tyr Met Pro Glu Thr Arg 
945                 950                 955                 960 


Leu Arg Ile Pro Ala Ala Glu Pro Ile Glu Tyr Ala Gln Phe Pro Phe 
                965                 970                 975     


Tyr Leu Asn Gly Leu Arg Asp Thr Ser Asp Phe Val Glu Ala Ile Glu 
            980                 985                 990         


Lys Val Arg Thr Ile Cys Ser Asn  Tyr Thr Ser Leu Gly  Leu Ser Ser 
        995                 1000                 1005             


Tyr Pro  Asn Gly Tyr Pro Phe  Leu Phe Trp Glu Gln  Tyr Ile Gly 
    1010                 1015                 1020             


Leu Arg  His Trp Leu Leu Leu  Phe Ile Ser Val Val  Leu Ala Cys 
    1025                 1030                 1035             


Thr Phe  Leu Val Cys Ala Val  Phe Leu Leu Asn Pro  Trp Thr Ala 
    1040                 1045                 1050             


Gly Ile  Ile Val Met Val Leu  Ala Leu Met Thr Val  Glu Leu Phe 
    1055                 1060                 1065             


Gly Met  Met Gly Leu Ile Gly  Ile Lys Leu Ser Ala  Val Pro Val 
    1070                 1075                 1080             


Val Ile  Leu Ile Ala Ser Val  Gly Ile Gly Val Glu  Phe Thr Val 
    1085                 1090                 1095             


His Val  Ala Leu Ala Phe Leu  Thr Ala Ile Gly Asp  Lys Asn Arg 
    1100                 1105                 1110             


Arg Ala  Val Leu Ala Leu Glu  His Met Phe Ala Pro  Val Leu Asp 
    1115                 1120                 1125             


Gly Ala  Val Ser Thr Leu Leu  Gly Val Leu Met Leu  Ala Gly Ser 
    1130                 1135                 1140             


Glu Phe  Asp Phe Ile Val Arg  Tyr Phe Phe Ala Val  Leu Ala Ile 
    1145                 1150                 1155             


Leu Thr  Ile Leu Gly Val Leu  Asn Gly Leu Val Leu  Leu Pro Val 
    1160                 1165                 1170             


Leu Leu  Ser Phe Phe Gly Pro  Tyr Pro Glu Val Ser  Pro Ala Asn 
    1175                 1180                 1185             


Gly Leu  Asn Arg Leu Pro Thr  Pro Ser Pro Glu Pro  Pro Pro Ser 
    1190                 1195                 1200             


Val Val  Arg Phe Ala Met Pro  Pro Gly His Thr His  Ser Gly Ser 
    1205                 1210                 1215             


Asp Ser  Ser Asp Ser Glu Tyr  Ser Ser Gln Thr Thr  Val Ser Gly 
    1220                 1225                 1230             


Leu Ser  Glu Glu Leu Arg His  Tyr Glu Ala Gln Gln  Gly Ala Gly 
    1235                 1240                 1245             


Gly Pro  Ala His Gln Val Ile  Val Glu Ala Thr Glu  Asn Pro Val 
    1250                 1255                 1260             


Phe Ala  His Ser Thr Val Val  His Pro Glu Ser Arg  His His Pro 
    1265                 1270                 1275             


Pro Ser  Asn Pro Arg Gln Gln  Pro His Leu Asp Ser  Gly Ser Leu 
    1280                 1285                 1290             


Pro Pro  Gly Arg Gln Gly Gln  Gln Pro Arg Arg Asp  Pro Pro Arg 
    1295                 1300                 1305             


Glu Gly  Leu Trp Pro Pro Pro  Tyr Arg Pro Arg Arg  Asp Ala Phe 
    1310                 1315                 1320             


Glu Ile  Ser Thr Glu Gly His  Ser Gly Pro Ser Asn  Arg Ala Arg 
    1325                 1330                 1335             


Trp Gly  Pro Arg Gly Ala Arg  Ser His Asn Pro Arg  Asn Pro Ala 
    1340                 1345                 1350             


Ser Thr  Ala Met Gly Ser Ser  Val Pro Gly Tyr Cys  Gln Pro Ile 
    1355                 1360                 1365             


Thr Thr  Val Thr Ala Ser Ala  Ser Val Thr Val Ala  Val His Pro 
    1370                 1375                 1380             


Pro Pro  Val Pro Gly Pro Gly  Arg Asn Pro Arg Gly  Gly Leu Cys 
    1385                 1390                 1395             


Pro Gly  Tyr Pro Glu Thr Asp  His Gly Leu Phe Glu  Asp Pro His 
    1400                 1405                 1410             


Val Pro  Phe His Val Arg Cys  Glu Arg Arg Asp Ser  Lys Val Glu 
    1415                 1420                 1425             


Val Ile  Glu Leu Gln Asp Val  Glu Cys Glu Glu Arg  Pro Arg Gly 
    1430                 1435                 1440             


Ser Ser  Ser Asn 
    1445         


<210>  78
<211>  1278
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Thr Ala Arg Gly Leu Ala Leu Gly Leu Leu Leu Leu Leu Leu Cys 
1               5                   10                  15      


Pro Ala Gln Val Phe Ser Gln Ser Cys Val Trp Tyr Gly Glu Cys Gly 
            20                  25                  30          


Ile Ala Tyr Gly Asp Lys Arg Tyr Asn Cys Glu Tyr Ser Gly Pro Pro 
        35                  40                  45              


Lys Pro Leu Pro Lys Asp Gly Tyr Asp Leu Val Gln Glu Leu Cys Pro 
    50                  55                  60                  


Gly Phe Phe Phe Gly Asn Val Ser Leu Cys Cys Asp Val Arg Gln Leu 
65                  70                  75                  80  


Gln Thr Leu Lys Asp Asn Leu Gln Leu Pro Leu Gln Phe Leu Ser Arg 
                85                  90                  95      


Cys Pro Ser Cys Phe Tyr Asn Leu Leu Asn Leu Phe Cys Glu Leu Thr 
            100                 105                 110         


Cys Ser Pro Arg Gln Ser Gln Phe Leu Asn Val Thr Ala Thr Glu Asp 
        115                 120                 125             


Tyr Val Asp Pro Val Thr Asn Gln Thr Lys Thr Asn Val Lys Glu Leu 
    130                 135                 140                 


Gln Tyr Tyr Val Gly Gln Ser Phe Ala Asn Ala Met Tyr Asn Ala Cys 
145                 150                 155                 160 


Arg Asp Val Glu Ala Pro Ser Ser Asn Asp Lys Ala Leu Gly Leu Leu 
                165                 170                 175     


Cys Gly Lys Asp Ala Asp Ala Cys Asn Ala Thr Asn Trp Ile Glu Tyr 
            180                 185                 190         


Met Phe Asn Lys Asp Asn Gly Gln Ala Pro Phe Thr Ile Thr Pro Val 
        195                 200                 205             


Phe Ser Asp Phe Pro Val His Gly Met Glu Pro Met Asn Asn Ala Thr 
    210                 215                 220                 


Lys Gly Cys Asp Glu Ser Val Asp Glu Val Thr Ala Pro Cys Ser Cys 
225                 230                 235                 240 


Gln Asp Cys Ser Ile Val Cys Gly Pro Lys Pro Gln Pro Pro Pro Pro 
                245                 250                 255     


Pro Ala Pro Trp Thr Ile Leu Gly Leu Asp Ala Met Tyr Val Ile Met 
            260                 265                 270         


Trp Ile Thr Tyr Met Ala Phe Leu Leu Val Phe Phe Gly Ala Phe Phe 
        275                 280                 285             


Ala Val Trp Cys Tyr Arg Lys Arg Tyr Phe Val Ser Glu Tyr Thr Pro 
    290                 295                 300                 


Ile Asp Ser Asn Ile Ala Phe Ser Val Asn Ala Ser Asp Lys Gly Glu 
305                 310                 315                 320 


Ala Ser Cys Cys Asp Pro Val Ser Ala Ala Phe Glu Gly Cys Leu Arg 
                325                 330                 335     


Arg Leu Phe Thr Arg Trp Gly Ser Phe Cys Val Arg Asn Pro Gly Cys 
            340                 345                 350         


Val Ile Phe Phe Ser Leu Val Phe Ile Thr Ala Cys Ser Ser Gly Leu 
        355                 360                 365             


Val Phe Val Arg Val Thr Thr Asn Pro Val Asp Leu Trp Ser Ala Pro 
    370                 375                 380                 


Ser Ser Gln Ala Arg Leu Glu Lys Glu Tyr Phe Asp Gln His Phe Gly 
385                 390                 395                 400 


Pro Phe Phe Arg Thr Glu Gln Leu Ile Ile Arg Ala Pro Leu Thr Asp 
                405                 410                 415     


Lys His Ile Tyr Gln Pro Tyr Pro Ser Gly Ala Asp Val Pro Phe Gly 
            420                 425                 430         


Pro Pro Leu Asp Ile Gln Ile Leu His Gln Val Leu Asp Leu Gln Ile 
        435                 440                 445             


Ala Ile Glu Asn Ile Thr Ala Ser Tyr Asp Asn Glu Thr Val Thr Leu 
    450                 455                 460                 


Gln Asp Ile Cys Leu Ala Pro Leu Ser Pro Tyr Asn Thr Asn Cys Thr 
465                 470                 475                 480 


Ile Leu Ser Val Leu Asn Tyr Phe Gln Asn Ser His Ser Val Leu Asp 
                485                 490                 495     


His Lys Lys Gly Asp Asp Phe Phe Val Tyr Ala Asp Tyr His Thr His 
            500                 505                 510         


Phe Leu Tyr Cys Val Arg Ala Pro Ala Ser Leu Asn Asp Thr Ser Leu 
        515                 520                 525             


Leu His Asp Pro Cys Leu Gly Thr Phe Gly Gly Pro Val Phe Pro Trp 
    530                 535                 540                 


Leu Val Leu Gly Gly Tyr Asp Asp Gln Asn Tyr Asn Asn Ala Thr Ala 
545                 550                 555                 560 


Leu Val Ile Thr Phe Pro Val Asn Asn Tyr Tyr Asn Asp Thr Glu Lys 
                565                 570                 575     


Leu Gln Arg Ala Gln Ala Trp Glu Lys Glu Phe Ile Asn Phe Val Lys 
            580                 585                 590         


Asn Tyr Lys Asn Pro Asn Leu Thr Ile Ser Phe Thr Ala Glu Arg Ser 
        595                 600                 605             


Ile Glu Asp Glu Leu Asn Arg Glu Ser Asp Ser Asp Val Phe Thr Val 
    610                 615                 620                 


Val Ile Ser Tyr Ala Ile Met Phe Leu Tyr Ile Ser Leu Ala Leu Gly 
625                 630                 635                 640 


His Met Lys Ser Cys Arg Arg Leu Leu Val Asp Ser Lys Val Ser Leu 
                645                 650                 655     


Gly Ile Ala Gly Ile Leu Ile Val Leu Ser Ser Val Ala Cys Ser Leu 
            660                 665                 670         


Gly Val Phe Ser Tyr Ile Gly Leu Pro Leu Thr Leu Ile Val Ile Glu 
        675                 680                 685             


Val Ile Pro Phe Leu Val Leu Ala Val Gly Val Asp Asn Ile Phe Ile 
    690                 695                 700                 


Leu Val Gln Ala Tyr Gln Arg Asp Glu Arg Leu Gln Gly Glu Thr Leu 
705                 710                 715                 720 


Asp Gln Gln Leu Gly Arg Val Leu Gly Glu Val Ala Pro Ser Met Phe 
                725                 730                 735     


Leu Ser Ser Phe Ser Glu Thr Val Ala Phe Phe Leu Gly Ala Leu Ser 
            740                 745                 750         


Val Met Pro Ala Val His Thr Phe Ser Leu Phe Ala Gly Leu Ala Val 
        755                 760                 765             


Phe Ile Asp Phe Leu Leu Gln Ile Thr Cys Phe Val Ser Leu Leu Gly 
    770                 775                 780                 


Leu Asp Ile Lys Arg Gln Glu Lys Asn Arg Leu Asp Ile Phe Cys Cys 
785                 790                 795                 800 


Val Arg Gly Ala Glu Asp Gly Thr Ser Val Gln Ala Ser Glu Ser Cys 
                805                 810                 815     


Leu Phe Arg Phe Phe Lys Asn Ser Tyr Ser Pro Leu Leu Leu Lys Asp 
            820                 825                 830         


Trp Met Arg Pro Ile Val Ile Ala Ile Phe Val Gly Val Leu Ser Phe 
        835                 840                 845             


Ser Ile Ala Val Leu Asn Lys Val Asp Ile Gly Leu Asp Gln Ser Leu 
    850                 855                 860                 


Ser Met Pro Asp Asp Ser Tyr Met Val Asp Tyr Phe Lys Ser Ile Ser 
865                 870                 875                 880 


Gln Tyr Leu His Ala Gly Pro Pro Val Tyr Phe Val Leu Glu Glu Gly 
                885                 890                 895     


His Asp Tyr Thr Ser Ser Lys Gly Gln Asn Met Val Cys Gly Gly Met 
            900                 905                 910         


Gly Cys Asn Asn Asp Ser Leu Val Gln Gln Ile Phe Asn Ala Ala Gln 
        915                 920                 925             


Leu Asp Asn Tyr Thr Arg Ile Gly Phe Ala Pro Ser Ser Trp Ile Asp 
    930                 935                 940                 


Asp Tyr Phe Asp Trp Val Lys Pro Gln Ser Ser Cys Cys Arg Val Asp 
945                 950                 955                 960 


Asn Ile Thr Asp Gln Phe Cys Asn Ala Ser Val Val Asp Pro Ala Cys 
                965                 970                 975     


Val Arg Cys Arg Pro Leu Thr Pro Glu Gly Lys Gln Arg Pro Gln Gly 
            980                 985                 990         


Gly Asp Phe Met Arg Phe Leu Pro  Met Phe Leu Ser Asp  Asn Pro Asn 
        995                 1000                 1005             


Pro Lys  Cys Gly Lys Gly Gly  His Ala Ala Tyr Ser  Ser Ala Val 
    1010                 1015                 1020             


Asn Ile  Leu Leu Gly His Gly  Thr Arg Val Gly Ala  Thr Tyr Phe 
    1025                 1030                 1035             


Met Thr  Tyr His Thr Val Leu  Gln Thr Ser Ala Asp  Phe Ile Asp 
    1040                 1045                 1050             


Ala Leu  Lys Lys Ala Arg Leu  Ile Ala Ser Asn Val  Thr Glu Thr 
    1055                 1060                 1065             


Met Gly  Ile Asn Gly Ser Ala  Tyr Arg Val Phe Pro  Tyr Ser Val 
    1070                 1075                 1080             


Phe Tyr  Val Phe Tyr Glu Gln  Tyr Leu Thr Ile Ile  Asp Asp Thr 
    1085                 1090                 1095             


Ile Phe  Asn Leu Gly Val Ser  Leu Gly Ala Ile Phe  Leu Val Thr 
    1100                 1105                 1110             


Met Val  Leu Leu Gly Cys Glu  Leu Trp Ser Ala Val  Ile Met Cys 
    1115                 1120                 1125             


Ala Thr  Ile Ala Met Val Leu  Val Asn Met Phe Gly  Val Met Trp 
    1130                 1135                 1140             


Leu Trp  Gly Ile Ser Leu Asn  Ala Val Ser Leu Val  Asn Leu Val 
    1145                 1150                 1155             


Met Ser  Cys Gly Ile Ser Val  Glu Phe Cys Ser His  Ile Thr Arg 
    1160                 1165                 1170             


Ala Phe  Thr Val Ser Met Lys  Gly Ser Arg Val Glu  Arg Ala Glu 
    1175                 1180                 1185             


Glu Ala  Leu Ala His Met Gly  Ser Ser Val Phe Ser  Gly Ile Thr 
    1190                 1195                 1200             


Leu Thr  Lys Phe Gly Gly Ile  Val Val Leu Ala Phe  Ala Lys Ser 
    1205                 1210                 1215             


Gln Ile  Phe Gln Ile Phe Tyr  Phe Arg Met Tyr Leu  Ala Met Val 
    1220                 1225                 1230             


Leu Leu  Gly Ala Thr His Gly  Leu Ile Phe Leu Pro  Val Leu Leu 
    1235                 1240                 1245             


Ser Tyr  Ile Gly Pro Ser Val  Asn Lys Ala Lys Ser  Cys Ala Thr 
    1250                 1255                 1260             


Glu Glu  Arg Tyr Lys Gly Thr  Glu Arg Glu Arg Leu  Leu Asn Phe 
    1265                 1270                 1275             


<210>  79
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Ala Ser Pro Arg Leu Gly Thr Phe Cys Cys Pro Thr Arg Asp Ala 
1               5                   10                  15      


Ala Thr Gln Leu Val Leu Ser Phe Gln Pro Arg Ala Phe His Ala Leu 
            20                  25                  30          


Cys Leu Gly Ser Gly Gly Leu Arg Leu Ala Leu Gly Leu Leu Gln Leu 
        35                  40                  45              


Leu Pro Gly Arg Arg Pro Ala Gly Pro Gly Ser Pro Ala Thr Ser Pro 
    50                  55                  60                  


Pro Ala Ser Val Arg Ile Leu Arg Ala Ala Ala Ala Cys Asp Leu Leu 
65                  70                  75                  80  


Gly Cys Leu Gly Met Val Ile Arg Ser Thr Val Trp Leu Gly Phe Pro 
                85                  90                  95      


Asn Phe Val Asp Ser Val Ser Asp Met Asn His Thr Glu Ile Trp Pro 
            100                 105                 110         


Ala Ala Phe Cys Val Gly Ser Ala Met Trp Ile Gln Leu Leu Tyr Ser 
        115                 120                 125             


Ala Cys Phe Trp Trp Leu Phe Cys Tyr Ala Val Asp Ala Tyr Leu Val 
    130                 135                 140                 


Ile Arg Arg Ser Ala Gly Leu Ser Thr Ile Leu Leu Tyr His Ile Met 
145                 150                 155                 160 


Ala Trp Gly Leu Ala Thr Leu Leu Cys Val Glu Gly Ala Ala Met Leu 
                165                 170                 175     


Tyr Tyr Pro Ser Val Ser Arg Cys Glu Arg Gly Leu Asp His Ala Ile 
            180                 185                 190         


Pro His Tyr Val Thr Met Tyr Leu Pro Leu Leu Leu Val Leu Val Ala 
        195                 200                 205             


Asn Pro Ile Leu Phe Gln Lys Thr Val Thr Ala Val Ala Ser Leu Leu 
    210                 215                 220                 


Lys Gly Arg Gln Gly Ile Tyr Thr Glu Asn Glu Arg Arg Met Gly Ala 
225                 230                 235                 240 


Val Ile Lys Ile Arg Phe Phe Lys Ile Met Leu Val Leu Ile Ile Cys 
                245                 250                 255     


Trp Leu Ser Asn Ile Ile Asn Glu Ser Leu Leu Phe Tyr Leu Glu Met 
            260                 265                 270         


Gln Thr Asp Ile Asn Gly Gly Ser Leu Lys Pro Val Arg Thr Ala Ala 
        275                 280                 285             


Lys Thr Thr Trp Phe Ile Met Gly Ile Leu Asn Pro Ala Gln Gly Phe 
    290                 295                 300                 


Leu Leu Ser Leu Ala Phe Tyr Gly Trp Thr Gly Cys Ser Leu Gly Phe 
305                 310                 315                 320 


Gln Ser Pro Arg Lys Glu Ile Gln Trp Glu Ser Leu Thr Thr Ser Ala 
                325                 330                 335     


Ala Glu Gly Ala His Pro Ser Pro Leu Met Pro His Glu Asn Pro Ala 
            340                 345                 350         


Ser Gly Lys Val Ser Gln Val Gly Gly Gln Thr Ser Asp Glu Ala Leu 
        355                 360                 365             


Ser Met Leu Ser Glu Gly Ser Asp Ala Ser Thr Ile Glu Ile His Thr 
    370                 375                 380                 


Ala Ser Glu Ser Cys Asn Lys Asn Glu Gly Asp Pro Ala Leu Pro Thr 
385                 390                 395                 400 


His Gly Asp Leu 
                


<210>  80
<211>  838
<212>  PRT
<213>  Homo sapiens

<400>  80

Met His Leu Glu Gly Arg Asp Gly Arg Arg Tyr Pro Gly Ala Pro Ala 
1               5                   10                  15      


Val Glu Leu Leu Gln Thr Ser Val Pro Ser Gly Leu Ala Glu Leu Val 
            20                  25                  30          


Ala Gly Lys Arg Arg Leu Pro Arg Gly Ala Gly Gly Ala Asp Pro Ser 
        35                  40                  45              


His Ser Cys Pro Arg Gly Ala Ala Gly Gln Ser Ser Trp Ala Pro Ala 
    50                  55                  60                  


Gly Gln Glu Phe Ala Ser Phe Leu Thr Lys Gly Arg Ser His Ser Ser 
65                  70                  75                  80  


Leu Pro Gln Met Ser Ser Ser Arg Ser Lys Asp Ser Cys Phe Thr Glu 
                85                  90                  95      


Asn Thr Pro Leu Leu Arg Asn Ser Leu Gln Glu Lys Gly Ser Arg Cys 
            100                 105                 110         


Ile Pro Val Tyr His Pro Glu Phe Ile Thr Ala Glu Glu Ser Trp Glu 
        115                 120                 125             


Asp Ser Ser Ala Asp Trp Glu Arg Arg Tyr Leu Leu Ser Arg Glu Val 
    130                 135                 140                 


Ser Gly Leu Ser Ala Ser Ala Ser Ser Glu Lys Gly Asp Leu Leu Asp 
145                 150                 155                 160 


Ser Pro His Ile Arg Leu Arg Leu Ser Lys Leu Arg Arg Cys Val Gln 
                165                 170                 175     


Trp Leu Lys Val Met Gly Leu Phe Ala Phe Val Val Leu Cys Ser Ile 
            180                 185                 190         


Leu Phe Ser Leu Tyr Pro Asp Gln Gly Lys Leu Trp Gln Leu Leu Ala 
        195                 200                 205             


Leu Ser Pro Leu Glu Asn Tyr Ser Val Asn Leu Ser Ser His Val Asp 
    210                 215                 220                 


Ser Thr Leu Leu Gln Val Asp Leu Ala Gly Ala Leu Val Ala Ser Gly 
225                 230                 235                 240 


Pro Ser Arg Pro Gly Arg Glu Glu His Ile Val Val Glu Leu Thr Gln 
                245                 250                 255     


Ala Asp Ala Leu Gly Ser Arg Trp Arg Arg Pro Gln Gln Val Thr His 
            260                 265                 270         


Asn Trp Thr Val Tyr Leu Asn Pro Arg Arg Ser Glu His Ser Val Met 
        275                 280                 285             


Ser Arg Thr Phe Glu Val Leu Thr Arg Glu Thr Val Ser Ile Ser Ile 
    290                 295                 300                 


Arg Ala Ser Leu Gln Gln Thr Gln Ala Val Pro Leu Leu Met Ala His 
305                 310                 315                 320 


Gln Tyr Leu Arg Gly Ser Val Glu Thr Gln Val Thr Ile Ala Thr Ala 
                325                 330                 335     


Ile Leu Ala Gly Val Tyr Ala Leu Ile Ile Phe Glu Ile Val His Arg 
            340                 345                 350         


Thr Leu Ala Ala Met Leu Gly Ser Leu Ala Ala Leu Ala Ala Leu Ala 
        355                 360                 365             


Val Ile Gly Asp Arg Pro Ser Leu Thr His Val Val Glu Trp Ile Asp 
    370                 375                 380                 


Phe Glu Thr Leu Ala Leu Leu Phe Gly Met Met Ile Leu Val Ala Ile 
385                 390                 395                 400 


Phe Ser Glu Thr Gly Phe Phe Asp Tyr Cys Ala Val Lys Ala Tyr Arg 
                405                 410                 415     


Leu Ser Arg Gly Arg Val Trp Ala Met Ile Ile Met Leu Cys Leu Ile 
            420                 425                 430         


Ala Ala Val Leu Ser Ala Phe Leu Asp Asn Val Thr Thr Met Leu Leu 
        435                 440                 445             


Phe Thr Pro Val Thr Ile Arg Leu Cys Glu Val Leu Asn Leu Asp Pro 
    450                 455                 460                 


Arg Gln Val Leu Ile Ala Glu Val Ile Phe Thr Asn Ile Gly Gly Ala 
465                 470                 475                 480 


Ala Thr Ala Ile Gly Asp Pro Pro Asn Val Ile Ile Val Ser Asn Gln 
                485                 490                 495     


Glu Leu Arg Lys Met Gly Leu Asp Phe Ala Gly Phe Thr Ala His Met 
            500                 505                 510         


Phe Ile Gly Ile Cys Leu Val Leu Leu Val Cys Phe Pro Leu Leu Arg 
        515                 520                 525             


Leu Leu Tyr Trp Asn Arg Lys Leu Tyr Asn Lys Glu Pro Ser Glu Ile 
    530                 535                 540                 


Val Glu Leu Lys His Glu Ile His Val Trp Arg Leu Thr Ala Gln Arg 
545                 550                 555                 560 


Ile Ser Pro Ala Ser Arg Glu Glu Thr Ala Val Arg Arg Leu Leu Leu 
                565                 570                 575     


Gly Lys Val Leu Ala Leu Glu His Leu Leu Ala Arg Arg Leu His Thr 
            580                 585                 590         


Phe His Arg Gln Ile Ser Gln Glu Asp Lys Asn Trp Glu Thr Asn Ile 
        595                 600                 605             


Gln Glu Leu Gln Lys Lys His Arg Ile Ser Asp Gly Ile Leu Leu Ala 
    610                 615                 620                 


Lys Cys Leu Thr Val Leu Gly Phe Val Ile Phe Met Phe Phe Leu Asn 
625                 630                 635                 640 


Ser Phe Val Pro Gly Ile His Leu Asp Leu Gly Trp Ile Ala Ile Leu 
                645                 650                 655     


Gly Ala Ile Trp Leu Leu Ile Leu Ala Asp Ile His Asp Phe Glu Ile 
            660                 665                 670         


Ile Leu His Arg Val Glu Trp Ala Thr Leu Leu Phe Phe Ala Ala Leu 
        675                 680                 685             


Phe Val Leu Met Glu Ala Leu Ala His Leu His Leu Ile Glu Tyr Val 
    690                 695                 700                 


Gly Glu Gln Thr Ala Leu Leu Ile Lys Met Val Pro Glu Glu Gln Arg 
705                 710                 715                 720 


Leu Ile Ala Ala Ile Val Leu Val Val Trp Val Ser Ala Leu Ala Ser 
                725                 730                 735     


Ser Leu Ile Asp Asn Ile Pro Phe Thr Ala Thr Met Ile Pro Val Leu 
            740                 745                 750         


Leu Asn Leu Ser His Asp Pro Glu Val Gly Leu Pro Ala Pro Pro Leu 
        755                 760                 765             


Met Tyr Ala Leu Ala Phe Gly Ala Cys Leu Gly Gly Asn Gly Thr Leu 
    770                 775                 780                 


Ile Gly Ala Ser Ala Asn Val Val Cys Ala Gly Ile Ala Glu Gln His 
785                 790                 795                 800 


Gly Tyr Gly Phe Ser Phe Met Glu Phe Phe Arg Leu Gly Phe Pro Met 
                805                 810                 815     


Met Val Val Ser Cys Thr Val Gly Met Cys Tyr Leu Leu Val Ala His 
            820                 825                 830         


Val Val Val Gly Trp Asn 
        835             


<210>  81
<211>  854
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Ser Leu Ser Glu Glu Gln Ala Arg Ser Phe Leu Asp Gln Asn Pro 
1               5                   10                  15      


Asp Phe Ala Arg Gln Tyr Phe Gly Lys Lys Leu Ser Pro Glu Asn Val 
            20                  25                  30          


Ala Ala Ala Cys Glu Asp Gly Cys Pro Pro Asp Cys Asp Ser Leu Arg 
        35                  40                  45              


Asp Leu Cys Gln Val Glu Glu Ser Thr Ala Leu Leu Glu Leu Val Gln 
    50                  55                  60                  


Asp Met Gln Glu Ser Ile Asn Met Glu Arg Val Val Phe Lys Val Leu 
65                  70                  75                  80  


Arg Arg Leu Cys Thr Leu Leu Gln Ala Asp Arg Cys Ser Leu Phe Met 
                85                  90                  95      


Tyr Arg Gln Arg Asn Gly Val Ala Glu Leu Ala Thr Arg Leu Phe Ser 
            100                 105                 110         


Val Gln Pro Asp Ser Val Leu Glu Asp Cys Leu Val Pro Pro Asp Ser 
        115                 120                 125             


Glu Ile Val Phe Pro Leu Asp Ile Gly Val Val Gly His Val Ala Gln 
    130                 135                 140                 


Thr Lys Lys Met Val Asn Val Glu Asp Val Ala Glu Cys Pro His Phe 
145                 150                 155                 160 


Ser Ser Phe Ala Asp Glu Leu Thr Asp Tyr Lys Thr Lys Asn Met Leu 
                165                 170                 175     


Ala Thr Pro Ile Met Asn Gly Lys Asp Val Val Ala Val Ile Met Ala 
            180                 185                 190         


Val Asn Lys Leu Asn Gly Pro Phe Phe Thr Ser Glu Asp Glu Asp Val 
        195                 200                 205             


Phe Leu Lys Tyr Leu Asn Phe Ala Thr Leu Tyr Leu Lys Ile Tyr His 
    210                 215                 220                 


Leu Ser Tyr Leu His Asn Cys Glu Thr Arg Arg Gly Gln Val Leu Leu 
225                 230                 235                 240 


Trp Ser Ala Asn Lys Val Phe Glu Glu Leu Thr Asp Ile Glu Arg Gln 
                245                 250                 255     


Phe His Lys Ala Phe Tyr Thr Val Arg Ala Tyr Leu Asn Cys Glu Arg 
            260                 265                 270         


Tyr Ser Val Gly Leu Leu Asp Met Thr Lys Glu Lys Glu Phe Phe Asp 
        275                 280                 285             


Val Trp Ser Val Leu Met Gly Glu Ser Gln Pro Tyr Ser Gly Pro Arg 
    290                 295                 300                 


Thr Pro Asp Gly Arg Glu Ile Val Phe Tyr Lys Val Ile Asp Tyr Ile 
305                 310                 315                 320 


Leu His Gly Lys Glu Glu Ile Lys Val Ile Pro Thr Pro Ser Ala Asp 
                325                 330                 335     


His Trp Ala Leu Ala Ser Gly Leu Pro Ser Tyr Val Ala Glu Ser Gly 
            340                 345                 350         


Phe Ile Cys Asn Ile Met Asn Ala Ser Ala Asp Glu Met Phe Lys Phe 
        355                 360                 365             


Gln Glu Gly Ala Leu Asp Asp Ser Gly Trp Leu Ile Lys Asn Val Leu 
    370                 375                 380                 


Ser Met Pro Ile Val Asn Lys Lys Glu Glu Ile Val Gly Val Ala Thr 
385                 390                 395                 400 


Phe Tyr Asn Arg Lys Asp Gly Lys Pro Phe Asp Glu Gln Asp Glu Val 
                405                 410                 415     


Leu Met Glu Ser Leu Thr Gln Phe Leu Gly Trp Ser Val Met Asn Thr 
            420                 425                 430         


Asp Thr Tyr Asp Lys Met Asn Lys Leu Glu Asn Arg Lys Asp Ile Ala 
        435                 440                 445             


Gln Asp Met Val Leu Tyr His Val Lys Cys Asp Arg Asp Glu Ile Gln 
    450                 455                 460                 


Leu Ile Leu Pro Thr Arg Ala Arg Leu Gly Lys Glu Pro Ala Asp Cys 
465                 470                 475                 480 


Asp Glu Asp Glu Leu Gly Glu Ile Leu Lys Glu Glu Leu Pro Gly Pro 
                485                 490                 495     


Thr Thr Phe Asp Ile Tyr Glu Phe His Phe Ser Asp Leu Glu Cys Thr 
            500                 505                 510         


Glu Leu Asp Leu Val Lys Cys Gly Ile Gln Met Tyr Tyr Glu Leu Gly 
        515                 520                 525             


Val Val Arg Lys Phe Gln Ile Pro Gln Glu Val Leu Val Arg Phe Leu 
    530                 535                 540                 


Phe Ser Ile Ser Lys Gly Tyr Arg Arg Ile Thr Tyr His Asn Trp Arg 
545                 550                 555                 560 


His Gly Phe Asn Val Ala Gln Thr Met Phe Thr Leu Leu Met Thr Gly 
                565                 570                 575     


Lys Leu Lys Ser Tyr Tyr Thr Asp Leu Glu Ala Phe Ala Met Val Thr 
            580                 585                 590         


Ala Gly Leu Cys His Asp Ile Asp His Arg Gly Thr Asn Asn Leu Tyr 
        595                 600                 605             


Gln Met Lys Ser Gln Asn Pro Leu Ala Lys Leu His Gly Ser Ser Ile 
    610                 615                 620                 


Leu Glu Arg His His Leu Glu Phe Gly Lys Phe Leu Leu Ser Glu Glu 
625                 630                 635                 640 


Thr Leu Asn Ile Tyr Gln Asn Leu Asn Arg Arg Gln His Glu His Val 
                645                 650                 655     


Ile His Leu Met Asp Ile Ala Ile Ile Ala Thr Asp Leu Ala Leu Tyr 
            660                 665                 670         


Phe Lys Lys Arg Ala Met Phe Gln Lys Ile Val Asp Glu Ser Lys Asn 
        675                 680                 685             


Tyr Gln Asp Lys Lys Ser Trp Val Glu Tyr Leu Ser Leu Glu Thr Thr 
    690                 695                 700                 


Arg Lys Glu Ile Val Met Ala Met Met Met Thr Ala Cys Asp Leu Ser 
705                 710                 715                 720 


Ala Ile Thr Lys Pro Trp Glu Val Gln Ser Lys Val Ala Leu Leu Val 
                725                 730                 735     


Ala Ala Glu Phe Trp Glu Gln Gly Asp Leu Glu Arg Thr Val Leu Asp 
            740                 745                 750         


Gln Gln Pro Ile Pro Met Met Asp Arg Asn Lys Ala Ala Glu Leu Pro 
        755                 760                 765             


Lys Leu Gln Val Gly Phe Ile Asp Phe Val Cys Thr Phe Val Tyr Lys 
    770                 775                 780                 


Glu Phe Ser Arg Phe His Glu Glu Ile Leu Pro Met Phe Asp Arg Leu 
785                 790                 795                 800 


Gln Asn Asn Arg Lys Glu Trp Lys Ala Leu Ala Asp Glu Tyr Glu Ala 
                805                 810                 815     


Lys Val Lys Ala Leu Glu Glu Lys Glu Glu Glu Glu Arg Val Ala Ala 
            820                 825                 830         


Lys Lys Val Gly Thr Glu Ile Cys Asn Gly Gly Pro Ala Pro Lys Ser 
        835                 840                 845             


Ser Thr Cys Cys Ile Leu 
    850                 


<210>  82
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
            20                  25                  30          


Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
        35                  40                  45              


Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
    50                  55                  60                  


Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
65                  70                  75                  80  


Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                85                  90                  95      


His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
            100                 105                 110         


Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
        115                 120                 125             


Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
    130                 135                 140                 


Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
145                 150                 155                 160 


Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                165                 170                 175     


Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
            180                 185                 190         


Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
        195                 200                 205             


Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
    210                 215                 220                 


Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val 
225                 230                 235                 240 


Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                245                 250                 255     


Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
            260                 265                 270         


Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
        275                 280                 285             


Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
    290                 295                 300                 


Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
305                 310                 315                 320 


Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                325                 330                 335     


Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
            340                 345                 350         


Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
        355                 360                 365             


Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
    370                 375                 380                 


Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
385                 390                 395                 400 


Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                405                 410                 415     


Gln Lys 
        


<210>  83
<211>  968
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Val Asn Ser Ser Arg Val Gln Pro Gln Gln Pro Gly Asp Ala Lys 
1               5                   10                  15      


Arg Pro Pro Ala Pro Arg Ala Pro Asp Pro Gly Arg Leu Met Ala Gly 
            20                  25                  30          


Cys Ala Ala Val Gly Ala Ser Leu Ala Ala Pro Gly Gly Leu Cys Glu 
        35                  40                  45              


Gln Arg Gly Leu Glu Ile Glu Met Gln Arg Ile Arg Gln Ala Ala Ala 
    50                  55                  60                  


Arg Asp Pro Pro Ala Gly Ala Ala Ala Ser Pro Ser Pro Pro Leu Ser 
65                  70                  75                  80  


Ser Cys Ser Arg Gln Ala Trp Ser Arg Asp Asn Pro Gly Phe Glu Ala 
                85                  90                  95      


Glu Glu Glu Glu Glu Glu Val Glu Gly Glu Glu Gly Gly Met Val Val 
            100                 105                 110         


Glu Met Asp Val Glu Trp Arg Pro Gly Ser Arg Arg Ser Ala Ala Ser 
        115                 120                 125             


Ser Ala Val Ser Ser Val Gly Ala Arg Ser Arg Gly Leu Gly Gly Tyr 
    130                 135                 140                 


His Gly Ala Gly His Pro Ser Gly Arg Arg Arg Arg Arg Glu Asp Gln 
145                 150                 155                 160 


Gly Pro Pro Cys Pro Ser Pro Val Gly Gly Gly Asp Pro Leu His Arg 
                165                 170                 175     


His Leu Pro Leu Glu Gly Gln Pro Pro Arg Val Ala Trp Ala Glu Arg 
            180                 185                 190         


Leu Val Arg Gly Leu Arg Gly Leu Trp Gly Thr Arg Leu Met Glu Glu 
        195                 200                 205             


Ser Ser Thr Asn Arg Glu Lys Tyr Leu Lys Ser Val Leu Arg Glu Leu 
    210                 215                 220                 


Val Thr Tyr Leu Leu Phe Leu Ile Val Leu Cys Ile Leu Thr Tyr Gly 
225                 230                 235                 240 


Met Met Ser Ser Asn Val Tyr Tyr Tyr Thr Arg Met Met Ser Gln Leu 
                245                 250                 255     


Phe Leu Asp Thr Pro Val Ser Lys Thr Glu Lys Thr Asn Phe Lys Thr 
            260                 265                 270         


Leu Ser Ser Met Glu Asp Phe Trp Lys Phe Thr Glu Gly Ser Leu Leu 
        275                 280                 285             


Asp Gly Leu Tyr Trp Lys Met Gln Pro Ser Asn Gln Thr Glu Ala Asp 
    290                 295                 300                 


Asn Arg Ser Phe Ile Phe Tyr Glu Asn Leu Leu Leu Gly Val Pro Arg 
305                 310                 315                 320 


Ile Arg Gln Leu Arg Val Arg Asn Gly Ser Cys Ser Ile Pro Gln Asp 
                325                 330                 335     


Leu Arg Asp Glu Ile Lys Glu Cys Tyr Asp Val Tyr Ser Val Ser Ser 
            340                 345                 350         


Glu Asp Arg Ala Pro Phe Gly Pro Arg Asn Gly Thr Ala Trp Ile Tyr 
        355                 360                 365             


Thr Ser Glu Lys Asp Leu Asn Gly Ser Ser His Trp Gly Ile Ile Ala 
    370                 375                 380                 


Thr Tyr Ser Gly Ala Gly Tyr Tyr Leu Asp Leu Ser Arg Thr Arg Glu 
385                 390                 395                 400 


Glu Thr Ala Ala Gln Val Ala Ser Leu Lys Lys Asn Val Trp Leu Asp 
                405                 410                 415     


Arg Gly Thr Arg Ala Thr Phe Ile Asp Phe Ser Val Tyr Asn Ala Asn 
            420                 425                 430         


Ile Asn Leu Phe Cys Val Val Arg Leu Leu Val Glu Phe Pro Ala Thr 
        435                 440                 445             


Gly Gly Val Ile Pro Ser Trp Gln Phe Gln Pro Leu Lys Leu Ile Arg 
    450                 455                 460                 


Tyr Val Thr Thr Phe Asp Phe Phe Leu Ala Ala Cys Glu Ile Ile Phe 
465                 470                 475                 480 


Cys Phe Phe Ile Phe Tyr Tyr Val Val Glu Glu Ile Leu Glu Ile Arg 
                485                 490                 495     


Ile His Lys Leu His Tyr Phe Arg Ser Phe Trp Asn Cys Leu Asp Val 
            500                 505                 510         


Val Ile Val Val Leu Ser Val Val Ala Ile Gly Ile Asn Ile Tyr Arg 
        515                 520                 525             


Thr Ser Asn Val Glu Val Leu Leu Gln Phe Leu Glu Asp Gln Asn Thr 
    530                 535                 540                 


Phe Pro Asn Phe Glu His Leu Ala Tyr Trp Gln Ile Gln Phe Asn Asn 
545                 550                 555                 560 


Ile Ala Ala Val Thr Val Phe Phe Val Trp Ile Lys Leu Phe Lys Phe 
                565                 570                 575     


Ile Asn Phe Asn Arg Thr Met Ser Gln Leu Ser Thr Thr Met Ser Arg 
            580                 585                 590         


Cys Ala Lys Asp Leu Phe Gly Phe Ala Ile Met Phe Phe Ile Ile Phe 
        595                 600                 605             


Leu Ala Tyr Ala Gln Leu Ala Tyr Leu Val Phe Gly Thr Gln Val Asp 
    610                 615                 620                 


Asp Phe Ser Thr Phe Gln Glu Cys Ile Phe Thr Gln Phe Arg Ile Ile 
625                 630                 635                 640 


Leu Gly Asp Ile Asn Phe Ala Glu Ile Glu Glu Ala Asn Arg Val Leu 
                645                 650                 655     


Gly Pro Ile Tyr Phe Thr Thr Phe Val Phe Phe Met Phe Phe Ile Leu 
            660                 665                 670         


Leu Asn Met Phe Leu Ala Ile Ile Asn Asp Thr Tyr Ser Glu Val Lys 
        675                 680                 685             


Ser Asp Leu Ala Gln Gln Lys Ala Glu Met Glu Leu Ser Asp Leu Ile 
    690                 695                 700                 


Arg Lys Gly Tyr His Lys Ala Leu Val Lys Leu Lys Leu Lys Lys Asn 
705                 710                 715                 720 


Thr Val Asp Asp Ile Ser Glu Ser Leu Arg Gln Gly Gly Gly Lys Leu 
                725                 730                 735     


Asn Phe Asp Glu Leu Arg Gln Asp Leu Lys Gly Lys Gly His Thr Asp 
            740                 745                 750         


Ala Glu Ile Glu Ala Ile Phe Thr Lys Tyr Asp Gln Asp Gly Asp Gln 
        755                 760                 765             


Glu Leu Thr Glu His Glu His Gln Gln Met Arg Asp Asp Leu Glu Lys 
    770                 775                 780                 


Glu Arg Glu Asp Leu Asp Leu Asp His Ser Ser Leu Pro Arg Pro Met 
785                 790                 795                 800 


Ser Ser Arg Ser Phe Pro Arg Ser Leu Asp Asp Ser Glu Glu Asp Asp 
                805                 810                 815     


Asp Glu Asp Ser Gly His Ser Ser Arg Arg Arg Gly Ser Ile Ser Ser 
            820                 825                 830         


Gly Val Ser Tyr Glu Glu Phe Gln Val Leu Val Arg Arg Val Asp Arg 
        835                 840                 845             


Met Glu His Ser Ile Gly Ser Ile Val Ser Lys Ile Asp Ala Val Ile 
    850                 855                 860                 


Val Lys Leu Glu Ile Met Glu Arg Ala Lys Leu Lys Arg Arg Glu Val 
865                 870                 875                 880 


Leu Gly Arg Leu Leu Asp Gly Val Ala Glu Asp Glu Arg Leu Gly Arg 
                885                 890                 895     


Asp Ser Glu Ile His Arg Glu Gln Met Glu Arg Leu Val Arg Glu Glu 
            900                 905                 910         


Leu Glu Arg Trp Glu Ser Asp Asp Ala Ala Ser Gln Ile Ser His Gly 
        915                 920                 925             


Leu Gly Thr Pro Val Gly Leu Asn Gly Gln Pro Arg Pro Arg Ser Ser 
    930                 935                 940                 


Arg Pro Ser Ser Ser Gln Ser Thr Glu Gly Met Glu Gly Ala Gly Gly 
945                 950                 955                 960 


Asn Gly Ser Ser Asn Val His Val 
                965             


<210>  84
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Lys Thr Leu Leu Leu Leu Ala Val Ile Met Ile Phe Gly Leu Leu 
1               5                   10                  15      


Gln Ala His Gly Asn Leu Val Asn Phe His Arg Met Ile Lys Leu Thr 
            20                  25                  30          


Thr Gly Lys Glu Ala Ala Leu Ser Tyr Gly Phe Tyr Gly Cys His Cys 
        35                  40                  45              


Gly Val Gly Gly Arg Gly Ser Pro Lys Asp Ala Thr Asp Arg Cys Cys 
    50                  55                  60                  


Val Thr His Asp Cys Cys Tyr Lys Arg Leu Glu Lys Arg Gly Cys Gly 
65                  70                  75                  80  


Thr Lys Phe Leu Ser Tyr Lys Phe Ser Asn Ser Gly Ser Arg Ile Thr 
                85                  90                  95      


Cys Ala Lys Gln Asp Ser Cys Arg Ser Gln Leu Cys Glu Cys Asp Lys 
            100                 105                 110         


Ala Ala Ala Thr Cys Phe Ala Arg Asn Lys Thr Thr Tyr Asn Lys Lys 
        115                 120                 125             


Tyr Gln Tyr Tyr Ser Asn Lys His Cys Arg Gly Ser Thr Pro Arg Cys 
    130                 135                 140                 


<210>  85
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Leu Leu Leu Leu Leu Ser Ile Ile Val Leu His Val Ala Val Leu 
1               5                   10                  15      


Val Leu Leu Phe Val Ser Thr Ile Val Ser Gln Trp Ile Val Gly Asn 
            20                  25                  30          


Gly His Ala Thr Asp Leu Trp Gln Asn Cys Ser Thr Ser Ser Ser Gly 
        35                  40                  45              


Asn Val His His Cys Phe Ser Ser Ser Pro Asn Glu Trp Leu Gln Ser 
    50                  55                  60                  


Val Gln Ala Thr Met Ile Leu Ser Ile Ile Phe Ser Ile Leu Ser Leu 
65                  70                  75                  80  


Phe Leu Phe Phe Cys Gln Leu Phe Thr Leu Thr Lys Gly Gly Arg Phe 
                85                  90                  95      


Tyr Ile Thr Gly Ile Phe Gln Ile Leu Ala Gly Leu Cys Val Met Ser 
            100                 105                 110         


Ala Ala Ala Ile Tyr Thr Val Arg His Pro Glu Trp His Leu Asn Ser 
        115                 120                 125             


Asp Tyr Ser Tyr Gly Phe Ala Tyr Ile Leu Ala Trp Val Ala Phe Pro 
    130                 135                 140                 


Leu Ala Leu Leu Ser Gly Val Ile Tyr Val Ile Leu Arg Lys Arg Glu 
145                 150                 155                 160 


<210>  86
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Gly Arg Leu Val Ala Val Gly Leu Leu Gly Ile Ala Leu Ala Leu 
1               5                   10                  15      


Leu Gly Glu Arg Leu Leu Ala Leu Arg Asn Arg Leu Lys Ala Ser Arg 
            20                  25                  30          


Glu Val Glu Ser Val Asp Leu Pro His Cys His Leu Ile Lys Gly Ile 
        35                  40                  45              


Glu Ala Gly Ser Glu Asp Ile Asp Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Phe Ser Val Gly Leu Lys Phe Pro Gly Leu His Ser Phe Ala Pro Asp 
65                  70                  75                  80  


Lys Pro Gly Gly Ile Leu Met Met Asp Leu Lys Glu Glu Lys Pro Arg 
                85                  90                  95      


Ala Arg Glu Leu Arg Ile Ser Arg Gly Phe Asp Leu Ala Ser Phe Asn 
            100                 105                 110         


Pro His Gly Ile Ser Thr Phe Ile Asp Asn Asp Asp Thr Val Tyr Leu 
        115                 120                 125             


Phe Val Val Asn His Pro Glu Phe Lys Asn Thr Val Glu Ile Phe Lys 
    130                 135                 140                 


Phe Glu Glu Ala Glu Asn Ser Leu Leu His Leu Lys Thr Val Lys His 
145                 150                 155                 160 


Glu Leu Leu Pro Ser Val Asn Asp Ile Thr Ala Val Gly Pro Ala His 
                165                 170                 175     


Phe Tyr Ala Thr Asn Asp His Tyr Phe Ser Asp Pro Phe Leu Lys Tyr 
            180                 185                 190         


Leu Glu Thr Tyr Leu Asn Leu His Trp Ala Asn Val Val Tyr Tyr Ser 
        195                 200                 205             


Pro Asn Glu Val Lys Val Val Ala Glu Gly Phe Asp Ser Ala Asn Gly 
    210                 215                 220                 


Ile Asn Ile Ser Pro Asp Asp Lys Tyr Ile Tyr Val Ala Asp Ile Leu 
225                 230                 235                 240 


Ala His Glu Ile His Val Leu Glu Lys His Thr Asn Met Asn Leu Thr 
                245                 250                 255     


Gln Leu Lys Val Leu Glu Leu Asp Thr Leu Val Asp Asn Leu Ser Ile 
            260                 265                 270         


Asp Pro Ser Ser Gly Asp Ile Trp Val Gly Cys His Pro Asn Gly Gln 
        275                 280                 285             


Lys Leu Phe Val Tyr Asp Pro Asn Asn Pro Pro Ser Ser Glu Val Leu 
    290                 295                 300                 


Arg Ile Gln Asn Ile Leu Ser Glu Lys Pro Thr Val Thr Thr Val Tyr 
305                 310                 315                 320 


Ala Asn Asn Gly Ser Val Leu Gln Gly Ser Ser Val Ala Ser Val Tyr 
                325                 330                 335     


Asp Gly Lys Leu Leu Ile Gly Thr Leu Tyr His Arg Ala Leu Tyr Cys 
            340                 345                 350         


Glu Leu 
        


<210>  87
<211>  498
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Thr Ser Ser Pro Arg Ala Pro Pro Gly Glu Gln Gly Arg Gly Gly 
1               5                   10                  15      


Ala Glu Met Ile Arg Ala Ala Pro Pro Pro Leu Phe Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Val Ser Trp Ala Ser Arg Gly Glu Ala Ala Pro 
        35                  40                  45              


Asp Gln Asp Glu Ile Gln Arg Leu Pro Gly Leu Ala Lys Gln Pro Ser 
    50                  55                  60                  


Phe Arg Gln Tyr Ser Gly Tyr Leu Lys Gly Ser Gly Ser Lys His Leu 
65                  70                  75                  80  


His Tyr Trp Phe Val Glu Ser Gln Lys Asp Pro Glu Asn Ser Pro Val 
                85                  90                  95      


Val Leu Trp Leu Asn Gly Gly Pro Gly Cys Ser Ser Leu Asp Gly Leu 
            100                 105                 110         


Leu Thr Glu His Gly Pro Phe Leu Val Gln Pro Asp Gly Val Thr Leu 
        115                 120                 125             


Glu Tyr Asn Pro Tyr Ser Trp Asn Leu Ile Ala Asn Val Leu Tyr Leu 
    130                 135                 140                 


Glu Ser Pro Ala Gly Val Gly Phe Ser Tyr Ser Asp Asp Lys Phe Tyr 
145                 150                 155                 160 


Ala Thr Asn Asp Thr Glu Val Ala Gln Ser Asn Phe Glu Ala Leu Gln 
                165                 170                 175     


Asp Phe Phe Arg Leu Phe Pro Glu Tyr Lys Asn Asn Lys Leu Phe Leu 
            180                 185                 190         


Thr Gly Glu Ser Tyr Ala Gly Ile Tyr Ile Pro Thr Leu Ala Val Leu 
        195                 200                 205             


Val Met Gln Asp Pro Ser Met Asn Leu Gln Gly Leu Ala Val Gly Asn 
    210                 215                 220                 


Gly Leu Ser Ser Tyr Glu Gln Asn Asp Asn Ser Leu Val Tyr Phe Ala 
225                 230                 235                 240 


Tyr Tyr His Gly Leu Leu Gly Asn Arg Leu Trp Ser Ser Leu Gln Thr 
                245                 250                 255     


His Cys Cys Ser Gln Asn Lys Cys Asn Phe Tyr Asp Asn Lys Asp Leu 
            260                 265                 270         


Glu Cys Val Thr Asn Leu Gln Glu Val Ala Arg Ile Val Gly Asn Ser 
        275                 280                 285             


Gly Leu Asn Ile Tyr Asn Leu Tyr Ala Pro Cys Ala Gly Gly Val Pro 
    290                 295                 300                 


Ser His Phe Arg Tyr Glu Lys Asp Thr Val Val Val Gln Asp Leu Gly 
305                 310                 315                 320 


Asn Ile Phe Thr Arg Leu Pro Leu Lys Arg Met Trp His Gln Ala Leu 
                325                 330                 335     


Leu Arg Ser Gly Asp Lys Val Arg Met Asp Pro Pro Cys Thr Asn Thr 
            340                 345                 350         


Thr Ala Ala Ser Thr Tyr Leu Asn Asn Pro Tyr Val Arg Lys Ala Leu 
        355                 360                 365             


Asn Ile Pro Glu Gln Leu Pro Gln Trp Asp Met Cys Asn Phe Leu Val 
    370                 375                 380                 


Asn Leu Gln Tyr Arg Arg Leu Tyr Arg Ser Met Asn Ser Gln Tyr Leu 
385                 390                 395                 400 


Lys Leu Leu Ser Ser Gln Lys Tyr Gln Ile Leu Leu Tyr Asn Gly Asp 
                405                 410                 415     


Val Asp Met Ala Cys Asn Phe Met Gly Asp Glu Trp Phe Val Asp Ser 
            420                 425                 430         


Leu Asn Gln Lys Met Glu Val Gln Arg Arg Pro Trp Leu Val Lys Tyr 
        435                 440                 445             


Gly Asp Ser Gly Glu Gln Ile Ala Gly Phe Val Lys Glu Phe Ser His 
    450                 455                 460                 


Ile Ala Phe Leu Thr Ile Lys Gly Ala Gly His Met Val Pro Thr Asp 
465                 470                 475                 480 


Lys Pro Leu Ala Ala Phe Thr Met Phe Ser Arg Phe Leu Asn Lys Gln 
                485                 490                 495     


Pro Tyr 
        


<210>  88
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Ala Asn Leu Gly Cys Trp Met Leu Val Leu Phe Val Ala Thr Trp 
1               5                   10                  15      


Ser Asp Leu Gly Leu Cys Lys Lys Arg Pro Lys Pro Gly Gly Trp Asn 
            20                  25                  30          


Thr Gly Gly Ser Arg Tyr Pro Gly Gln Gly Ser Pro Gly Gly Asn Arg 
        35                  40                  45              


Tyr Pro Pro Gln Gly Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly 
    50                  55                  60                  


Trp Gly Gln Pro His Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly 
65                  70                  75                  80  


Trp Gly Gln Pro His Gly Gly Gly Trp Gly Gln Gly Gly Gly Thr His 
                85                  90                  95      


Ser Gln Trp Asn Lys Pro Ser Lys Pro Lys Thr Asn Met Lys His Met 
            100                 105                 110         


Ala Gly Ala Ala Ala Ala Gly Ala Val Val Gly Gly Leu Gly Gly Tyr 
        115                 120                 125             


Met Leu Gly Ser Ala Met Ser Arg Pro Ile Ile His Phe Gly Ser Asp 
    130                 135                 140                 


Tyr Glu Asp Arg Tyr Tyr Arg Glu Asn Met His Arg Tyr Pro Asn Gln 
145                 150                 155                 160 


Val Tyr Tyr Arg Pro Met Asp Glu Tyr Ser Asn Gln Asn Asn Phe Val 
                165                 170                 175     


His Asp Cys Val Asn Ile Thr Ile Lys Gln His Thr Val Thr Thr Thr 
            180                 185                 190         


Thr Lys Gly Glu Asn Phe Thr Glu Thr Asp Val Lys Met Met Glu Arg 
        195                 200                 205             


Val Val Glu Gln Met Cys Ile Thr Gln Tyr Glu Arg Glu Ser Gln Ala 
    210                 215                 220                 


Tyr Tyr Gln Arg Gly Ser Ser Met Val Leu Phe Ser Ser Pro Pro Val 
225                 230                 235                 240 


Ile Leu Leu Ile Ser Phe Leu Ile Phe Leu Ile Val Gly 
                245                 250             


<210>  89
<211>  676
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Arg Val Leu Gly Gly Arg Cys Gly Ala Leu Leu Ala Cys Leu Leu 
1               5                   10                  15      


Leu Val Leu Pro Val Ser Glu Ala Asn Phe Leu Ser Lys Gln Gln Ala 
            20                  25                  30          


Ser Gln Val Leu Val Arg Lys Arg Arg Ala Asn Ser Leu Leu Glu Glu 
        35                  40                  45              


Thr Lys Gln Gly Asn Leu Glu Arg Glu Cys Ile Glu Glu Leu Cys Asn 
    50                  55                  60                  


Lys Glu Glu Ala Arg Glu Val Phe Glu Asn Asp Pro Glu Thr Asp Tyr 
65                  70                  75                  80  


Phe Tyr Pro Lys Tyr Leu Val Cys Leu Arg Ser Phe Gln Thr Gly Leu 
                85                  90                  95      


Phe Thr Ala Ala Arg Gln Ser Thr Asn Ala Tyr Pro Asp Leu Arg Ser 
            100                 105                 110         


Cys Val Asn Ala Ile Pro Asp Gln Cys Ser Pro Leu Pro Cys Asn Glu 
        115                 120                 125             


Asp Gly Tyr Met Ser Cys Lys Asp Gly Lys Ala Ser Phe Thr Cys Thr 
    130                 135                 140                 


Cys Lys Pro Gly Trp Gln Gly Glu Lys Cys Glu Phe Asp Ile Asn Glu 
145                 150                 155                 160 


Cys Lys Asp Pro Ser Asn Ile Asn Gly Gly Cys Ser Gln Ile Cys Asp 
                165                 170                 175     


Asn Thr Pro Gly Ser Tyr His Cys Ser Cys Lys Asn Gly Phe Val Met 
            180                 185                 190         


Leu Ser Asn Lys Lys Asp Cys Lys Asp Val Asp Glu Cys Ser Leu Lys 
        195                 200                 205             


Pro Ser Ile Cys Gly Thr Ala Val Cys Lys Asn Ile Pro Gly Asp Phe 
    210                 215                 220                 


Glu Cys Glu Cys Pro Glu Gly Tyr Arg Tyr Asn Leu Lys Ser Lys Ser 
225                 230                 235                 240 


Cys Glu Asp Ile Asp Glu Cys Ser Glu Asn Met Cys Ala Gln Leu Cys 
                245                 250                 255     


Val Asn Tyr Pro Gly Gly Tyr Thr Cys Tyr Cys Asp Gly Lys Lys Gly 
            260                 265                 270         


Phe Lys Leu Ala Gln Asp Gln Lys Ser Cys Glu Val Val Ser Val Cys 
        275                 280                 285             


Leu Pro Leu Asn Leu Asp Thr Lys Tyr Glu Leu Leu Tyr Leu Ala Glu 
    290                 295                 300                 


Gln Phe Ala Gly Val Val Leu Tyr Leu Lys Phe Arg Leu Pro Glu Ile 
305                 310                 315                 320 


Ser Arg Phe Ser Ala Glu Phe Asp Phe Arg Thr Tyr Asp Ser Glu Gly 
                325                 330                 335     


Val Ile Leu Tyr Ala Glu Ser Ile Asp His Ser Ala Trp Leu Leu Ile 
            340                 345                 350         


Ala Leu Arg Gly Gly Lys Ile Glu Val Gln Leu Lys Asn Glu His Thr 
        355                 360                 365             


Ser Lys Ile Thr Thr Gly Gly Asp Val Ile Asn Asn Gly Leu Trp Asn 
    370                 375                 380                 


Met Val Ser Val Glu Glu Leu Glu His Ser Ile Ser Ile Lys Ile Ala 
385                 390                 395                 400 


Lys Glu Ala Val Met Asp Ile Asn Lys Pro Gly Pro Leu Phe Lys Pro 
                405                 410                 415     


Glu Asn Gly Leu Leu Glu Thr Lys Val Tyr Phe Ala Gly Phe Pro Arg 
            420                 425                 430         


Lys Val Glu Ser Glu Leu Ile Lys Pro Ile Asn Pro Arg Leu Asp Gly 
        435                 440                 445             


Cys Ile Arg Ser Trp Asn Leu Met Lys Gln Gly Ala Ser Gly Ile Lys 
    450                 455                 460                 


Glu Ile Ile Gln Glu Lys Gln Asn Lys His Cys Leu Val Thr Val Glu 
465                 470                 475                 480 


Lys Gly Ser Tyr Tyr Pro Gly Ser Gly Ile Ala Gln Phe His Ile Asp 
                485                 490                 495     


Tyr Asn Asn Val Ser Ser Ala Glu Gly Trp His Val Asn Val Thr Leu 
            500                 505                 510         


Asn Ile Arg Pro Ser Thr Gly Thr Gly Val Met Leu Ala Leu Val Ser 
        515                 520                 525             


Gly Asn Asn Thr Val Pro Phe Ala Val Ser Leu Val Asp Ser Thr Ser 
    530                 535                 540                 


Glu Lys Ser Gln Asp Ile Leu Leu Ser Val Glu Asn Thr Val Ile Tyr 
545                 550                 555                 560 


Arg Ile Gln Ala Leu Ser Leu Cys Ser Asp Gln Gln Ser His Leu Glu 
                565                 570                 575     


Phe Arg Val Asn Arg Asn Asn Leu Glu Leu Ser Thr Pro Leu Lys Ile 
            580                 585                 590         


Glu Thr Ile Ser His Glu Asp Leu Gln Arg Gln Leu Ala Val Leu Asp 
        595                 600                 605             


Lys Ala Met Lys Ala Lys Val Ala Thr Tyr Leu Gly Gly Leu Pro Asp 
    610                 615                 620                 


Val Pro Phe Ser Ala Thr Pro Val Asn Ala Phe Tyr Asn Gly Cys Met 
625                 630                 635                 640 


Glu Val Asn Ile Asn Gly Val Gln Leu Asp Leu Asp Glu Ala Ile Ser 
                645                 650                 655     


Lys His Asn Asp Ile Arg Ala His Ser Cys Pro Ser Val Trp Lys Lys 
            660                 665                 670         


Thr Lys Asn Ser 
        675     


<210>  90
<211>  593
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Gly Thr Ala Arg Ile Ala Pro Gly Leu Ala Leu Leu Leu Cys Cys 
1               5                   10                  15      


Pro Val Leu Ser Ser Ala Tyr Ala Leu Val Asp Ala Asp Asp Val Met 
            20                  25                  30          


Thr Lys Glu Glu Gln Ile Phe Leu Leu His Arg Ala Gln Ala Gln Cys 
        35                  40                  45              


Glu Lys Arg Leu Lys Glu Val Leu Gln Arg Pro Ala Ser Ile Met Glu 
    50                  55                  60                  


Ser Asp Lys Gly Trp Thr Ser Ala Ser Thr Ser Gly Lys Pro Arg Lys 
65                  70                  75                  80  


Asp Lys Ala Ser Gly Lys Leu Tyr Pro Glu Ser Glu Glu Asp Lys Glu 
                85                  90                  95      


Ala Pro Thr Gly Ser Arg Tyr Arg Gly Arg Pro Cys Leu Pro Glu Trp 
            100                 105                 110         


Asp His Ile Leu Cys Trp Pro Leu Gly Ala Pro Gly Glu Val Val Ala 
        115                 120                 125             


Val Pro Cys Pro Asp Tyr Ile Tyr Asp Phe Asn His Lys Gly His Ala 
    130                 135                 140                 


Tyr Arg Arg Cys Asp Arg Asn Gly Ser Trp Glu Leu Val Pro Gly His 
145                 150                 155                 160 


Asn Arg Thr Trp Ala Asn Tyr Ser Glu Cys Val Lys Phe Leu Thr Asn 
                165                 170                 175     


Glu Thr Arg Glu Arg Glu Val Phe Asp Arg Leu Gly Met Ile Tyr Thr 
            180                 185                 190         


Val Gly Tyr Ser Val Ser Leu Ala Ser Leu Thr Val Ala Val Leu Ile 
        195                 200                 205             


Leu Ala Tyr Phe Arg Arg Leu His Cys Thr Arg Asn Tyr Ile His Met 
    210                 215                 220                 


His Leu Phe Leu Ser Phe Met Leu Arg Ala Val Ser Ile Phe Val Lys 
225                 230                 235                 240 


Asp Ala Val Leu Tyr Ser Gly Ala Thr Leu Asp Glu Ala Glu Arg Leu 
                245                 250                 255     


Thr Glu Glu Glu Leu Arg Ala Ile Ala Gln Ala Pro Pro Pro Pro Ala 
            260                 265                 270         


Thr Ala Ala Ala Gly Tyr Ala Gly Cys Arg Val Ala Val Thr Phe Phe 
        275                 280                 285             


Leu Tyr Phe Leu Ala Thr Asn Tyr Tyr Trp Ile Leu Val Glu Gly Leu 
    290                 295                 300                 


Tyr Leu His Ser Leu Ile Phe Met Ala Phe Phe Ser Glu Lys Lys Tyr 
305                 310                 315                 320 


Leu Trp Gly Phe Thr Val Phe Gly Trp Gly Leu Pro Ala Val Phe Val 
                325                 330                 335     


Ala Val Trp Val Ser Val Arg Ala Thr Leu Ala Asn Thr Gly Cys Trp 
            340                 345                 350         


Asp Leu Ser Ser Gly Asn Lys Lys Trp Ile Ile Gln Val Pro Ile Leu 
        355                 360                 365             


Ala Ser Ile Val Leu Asn Phe Ile Leu Phe Ile Asn Ile Val Arg Val 
    370                 375                 380                 


Leu Ala Thr Lys Leu Arg Glu Thr Asn Ala Gly Arg Cys Asp Thr Arg 
385                 390                 395                 400 


Gln Gln Tyr Arg Lys Leu Leu Lys Ser Thr Leu Val Leu Met Pro Leu 
                405                 410                 415     


Phe Gly Val His Tyr Ile Val Phe Met Ala Thr Pro Tyr Thr Glu Val 
            420                 425                 430         


Ser Gly Thr Leu Trp Gln Val Gln Met His Tyr Glu Met Leu Phe Asn 
        435                 440                 445             


Ser Phe Gln Gly Phe Phe Val Ala Ile Ile Tyr Cys Phe Cys Asn Gly 
    450                 455                 460                 


Glu Val Gln Ala Glu Ile Lys Lys Ser Trp Ser Arg Trp Thr Leu Ala 
465                 470                 475                 480 


Leu Asp Phe Lys Arg Lys Ala Arg Ser Gly Ser Ser Ser Tyr Ser Tyr 
                485                 490                 495     


Gly Pro Met Val Ser His Thr Ser Val Thr Asn Val Gly Pro Arg Val 
            500                 505                 510         


Gly Leu Gly Leu Pro Leu Ser Pro Arg Leu Leu Pro Thr Ala Thr Thr 
        515                 520                 525             


Asn Gly His Pro Gln Leu Pro Gly His Ala Lys Pro Gly Thr Pro Ala 
    530                 535                 540                 


Leu Glu Thr Leu Glu Thr Thr Pro Pro Ala Met Ala Ala Pro Lys Asp 
545                 550                 555                 560 


Asp Gly Phe Leu Asn Gly Ser Cys Ser Gly Leu Asp Glu Glu Ala Ser 
                565                 570                 575     


Gly Pro Glu Arg Pro Pro Ala Leu Leu Gln Glu Glu Trp Glu Thr Val 
            580                 585                 590         


Met 
    


<210>  91
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Ala Ser Arg Lys Glu Asn Ala Lys Ser Ala Asn Arg Val Leu Arg 
1               5                   10                  15      


Ile Ser Gln Leu Asp Ala Leu Glu Leu Asn Lys Ala Leu Glu Gln Leu 
            20                  25                  30          


Val Trp Ser Gln Phe Thr Gln Cys Phe His Gly Phe Lys Pro Gly Leu 
        35                  40                  45              


Leu Ala Arg Phe Glu Pro Glu Val Lys Ala Cys Leu Trp Val Phe Leu 
    50                  55                  60                  


Trp Arg Phe Thr Ile Tyr Ser Lys Asn Ala Thr Val Gly Gln Ser Val 
65                  70                  75                  80  


Leu Asn Ile Lys Tyr Lys Asn Asp Phe Ser Pro Asn Leu Arg Tyr Gln 
                85                  90                  95      


Pro Pro Ser Lys Asn Gln Lys Ile Trp Tyr Ala Val Cys Thr Ile Gly 
            100                 105                 110         


Gly Arg Trp Leu Glu Glu Arg Cys Tyr Asp Leu Phe Arg Asn His His 
        115                 120                 125             


Leu Ala Ser Phe Gly Lys Val Lys Gln Cys Val Asn Phe Val Ile Gly 
    130                 135                 140                 


Leu Leu Lys Leu Gly Gly Leu Ile Asn Phe Leu Ile Phe Leu Gln Arg 
145                 150                 155                 160 


Gly Lys Phe Ala Thr Leu Thr Glu Arg Leu Leu Gly Ile His Ser Val 
                165                 170                 175     


Phe Cys Lys Pro Gln Asn Ile Arg Glu Val Gly Phe Glu Tyr Met Asn 
            180                 185                 190         


Arg Glu Leu Leu Trp His Gly Phe Ala Glu Phe Leu Ile Phe Leu Leu 
        195                 200                 205             


Pro Leu Ile Asn Val Gln Lys Leu Lys Ala Lys Leu Ser Ser Trp Cys 
    210                 215                 220                 


Ile Pro Leu Thr Gly Ala Pro Asn Ser Asp Asn Thr Leu Ala Thr Ser 
225                 230                 235                 240 


Gly Lys Glu Cys Ala Leu Cys Gly Glu Trp Pro Thr Met Pro His Thr 
                245                 250                 255     


Ile Gly Cys Glu His Ile Phe Cys Tyr Phe Cys Ala Lys Ser Ser Phe 
            260                 265                 270         


Leu Phe Asp Val Tyr Phe Thr Cys Pro Lys Cys Gly Thr Glu Val His 
        275                 280                 285             


Ser Leu Gln Pro Leu Lys Ser Gly Ile Glu Met Ser Glu Val Asn Ala 
    290                 295                 300                 


Leu 
305 


<210>  92
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Ala Leu Leu Lys Val Lys Phe Asp Gln Lys Lys Arg Val Lys Leu 
1               5                   10                  15      


Ala Gln Gly Leu Trp Leu Met Asn Trp Phe Ser Val Leu Ala Gly Ile 
            20                  25                  30          


Ile Ile Phe Ser Leu Gly Leu Phe Leu Lys Ile Glu Leu Arg Lys Arg 
        35                  40                  45              


Ser Asp Val Met Asn Asn Ser Glu Ser His Phe Val Pro Asn Ser Leu 
    50                  55                  60                  


Ile Gly Met Gly Val Leu Ser Cys Val Phe Asn Ser Leu Ala Gly Lys 
65                  70                  75                  80  


Ile Cys Tyr Asp Ala Leu Asp Pro Ala Lys Tyr Ala Arg Trp Lys Pro 
                85                  90                  95      


Trp Leu Lys Pro Tyr Leu Ala Ile Cys Val Leu Phe Asn Ile Ile Leu 
            100                 105                 110         


Phe Leu Val Ala Leu Cys Cys Phe Leu Leu Arg Gly Ser Leu Glu Asn 
        115                 120                 125             


Thr Leu Gly Gln Gly Leu Lys Asn Gly Met Lys Tyr Tyr Arg Asp Thr 
    130                 135                 140                 


Asp Thr Pro Gly Arg Cys Phe Met Lys Lys Thr Ile Asp Met Leu Gln 
145                 150                 155                 160 


Ile Glu Phe Lys Cys Cys Gly Asn Asn Gly Phe Arg Asp Trp Phe Glu 
                165                 170                 175     


Ile Gln Trp Ile Ser Asn Arg Tyr Leu Asp Phe Ser Ser Lys Glu Val 
            180                 185                 190         


Lys Asp Arg Ile Lys Ser Asn Val Asp Gly Arg Tyr Leu Val Asp Gly 
        195                 200                 205             


Val Pro Phe Ser Cys Cys Asn Pro Ser Ser Pro Arg Pro Cys Ile Gln 
    210                 215                 220                 


Tyr Gln Ile Thr Asn Asn Ser Ala His Tyr Ser Tyr Asp His Gln Thr 
225                 230                 235                 240 


Glu Glu Leu Asn Leu Trp Val Arg Gly Cys Arg Ala Ala Leu Leu Ser 
                245                 250                 255     


Tyr Tyr Ser Ser Leu Met Asn Ser Met Gly Val Val Thr Leu Leu Ile 
            260                 265                 270         


Trp Leu Phe Glu Val Thr Ile Thr Ile Gly Leu Arg Tyr Leu Gln Thr 
        275                 280                 285             


Ser Leu Asp Gly Val Ser Asn Pro Glu Glu Ser Glu Ser Glu Ser Gln 
    290                 295                 300                 


Gly Trp Leu Leu Glu Arg Ser Val Pro Glu Thr Trp Lys Ala Phe Leu 
305                 310                 315                 320 


Glu Ser Val Lys Lys Leu Gly Lys Gly Asn Gln Val Glu Ala Glu Gly 
                325                 330                 335     


Ala Asp Ala Gly Gln Ala Pro Glu Ala Gly 
            340                 345     


<210>  93
<211>  409
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Arg Phe Thr Phe Pro Leu Met Ala Ile Val Leu Glu Ile Ala Met 
1               5                   10                  15      


Ile Val Leu Phe Gly Leu Phe Val Glu Tyr Glu Thr Asp Gln Thr Val 
            20                  25                  30          


Leu Glu Gln Leu Asn Ile Thr Lys Pro Thr Asp Met Gly Ile Phe Phe 
        35                  40                  45              


Glu Leu Tyr Pro Leu Phe Gln Asp Val His Val Met Ile Phe Val Gly 
    50                  55                  60                  


Phe Gly Phe Leu Met Thr Phe Leu Lys Lys Tyr Gly Phe Ser Ser Val 
65                  70                  75                  80  


Gly Ile Asn Leu Leu Val Ala Ala Leu Gly Leu Gln Trp Gly Thr Ile 
                85                  90                  95      


Val Gln Gly Ile Leu Gln Ser Gln Gly Gln Lys Phe Asn Ile Gly Ile 
            100                 105                 110         


Lys Asn Met Ile Asn Ala Asp Phe Ser Ala Ala Thr Val Leu Ile Ser 
        115                 120                 125             


Phe Gly Ala Val Leu Gly Lys Thr Ser Pro Thr Gln Met Leu Ile Met 
    130                 135                 140                 


Thr Ile Leu Glu Ile Val Phe Phe Ala His Asn Glu Tyr Leu Val Ser 
145                 150                 155                 160 


Glu Ile Phe Lys Ala Ser Asp Ile Gly Ala Ser Met Thr Ile His Ala 
                165                 170                 175     


Phe Gly Ala Tyr Phe Gly Leu Ala Val Ala Gly Ile Leu Tyr Arg Ser 
            180                 185                 190         


Gly Leu Arg Lys Gly His Glu Asn Glu Glu Ser Ala Tyr Tyr Ser Asp 
        195                 200                 205             


Leu Phe Ala Met Ile Gly Thr Leu Phe Leu Trp Met Phe Trp Pro Ser 
    210                 215                 220                 


Phe Asn Ser Ala Ile Ala Glu Pro Gly Asp Lys Gln Cys Arg Ala Ile 
225                 230                 235                 240 


Val Asn Thr Tyr Phe Ser Leu Ala Ala Cys Val Leu Thr Ala Phe Ala 
                245                 250                 255     


Phe Ser Ser Leu Val Glu His Arg Gly Lys Leu Asn Met Val His Ile 
            260                 265                 270         


Gln Asn Ala Thr Leu Ala Gly Gly Val Ala Val Gly Thr Cys Ala Asp 
        275                 280                 285             


Met Ala Ile His Pro Phe Gly Ser Met Ile Ile Gly Ser Ile Ala Gly 
    290                 295                 300                 


Met Val Ser Val Leu Gly Tyr Lys Phe Leu Thr Pro Leu Phe Thr Thr 
305                 310                 315                 320 


Lys Leu Arg Ile His Asp Thr Cys Gly Val His Asn Leu His Gly Leu 
                325                 330                 335     


Pro Gly Val Val Gly Gly Leu Ala Gly Ile Val Ala Val Ala Met Gly 
            340                 345                 350         


Ala Ser Asn Thr Ser Met Ala Met Gln Ala Ala Ala Leu Gly Ser Ser 
        355                 360                 365             


Ile Gly Thr Ala Val Val Gly Gly Leu Met Thr Gly Leu Ile Leu Lys 
    370                 375                 380                 


Leu Pro Leu Trp Gly Gln Pro Ser Asp Gln Asn Cys Tyr Asp Asp Ser 
385                 390                 395                 400 


Val Tyr Trp Lys Val Pro Lys Thr Arg 
                405                 


<210>  94
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Ala Pro Val Leu Pro Leu Val Leu Pro Leu Gln Pro Arg Ile Arg 
1               5                   10                  15      


Leu Ala Gln Gly Leu Trp Leu Leu Ser Trp Leu Leu Ala Leu Ala Gly 
            20                  25                  30          


Gly Val Ile Leu Leu Cys Ser Gly His Leu Leu Val Gln Leu Arg His 
        35                  40                  45              


Leu Gly Thr Phe Leu Ala Pro Ser Cys Gln Phe Pro Val Leu Pro Gln 
    50                  55                  60                  


Ala Ala Leu Ala Ala Gly Ala Val Ala Leu Gly Thr Gly Leu Val Gly 
65                  70                  75                  80  


Val Gly Ala Ser Arg Ala Ser Leu Asn Ala Ala Leu Tyr Pro Pro Trp 
                85                  90                  95      


Arg Gly Val Leu Gly Pro Leu Leu Val Ala Gly Thr Ala Gly Gly Gly 
            100                 105                 110         


Gly Leu Leu Val Val Ala Leu Gly Leu Ala Leu Ala Leu Pro Gly Ser 
        115                 120                 125             


Leu Asp Glu Ala Leu Glu Glu Gly Leu Val Thr Ala Leu Ala His Tyr 
    130                 135                 140                 


Lys Asp Thr Glu Val Pro Gly His Cys Gln Ala Lys Arg Leu Val Asp 
145                 150                 155                 160 


Glu Leu Gln Leu Arg Tyr His Cys Cys Gly Arg His Gly Tyr Lys Asp 
                165                 170                 175     


Trp Phe Gly Val Gln Trp Val Ser Ser Arg Tyr Leu Asp Pro Gly Asp 
            180                 185                 190         


Arg Asp Val Ala Asp Arg Ile Gln Ser Asn Val Glu Gly Leu Tyr Leu 
        195                 200                 205             


Thr Asp Gly Val Pro Phe Ser Cys Cys Asn Pro His Ser Pro Arg Pro 
    210                 215                 220                 


Cys Leu Gln Asn Arg Leu Ser Asp Ser Tyr Ala His Pro Leu Phe Asp 
225                 230                 235                 240 


Pro Arg Gln Pro Asn Gln Asn Leu Trp Ala Gln Gly Cys His Glu Val 
                245                 250                 255     


Leu Leu Glu His Leu Gln Asp Leu Ala Gly Thr Leu Gly Ser Met Leu 
            260                 265                 270         


Ala Val Thr Phe Leu Leu Gln Ala Leu Val Leu Leu Gly Leu Arg Tyr 
        275                 280                 285             


Leu Gln Thr Ala Leu Glu Gly Leu Gly Gly Val Ile Asp Ala Gly Gly 
    290                 295                 300                 


Glu Thr Gln Gly Tyr Leu Phe Pro Ser Gly Leu Lys Asp Met Leu Lys 
305                 310                 315                 320 


Thr Ala Trp Leu Gln Gly Gly Val Ala Cys Arg Pro Ala Pro Glu Glu 
                325                 330                 335     


Ala Pro Pro Gly Glu Ala Pro Pro Lys Glu Asp Leu Ser Glu Ala 
            340                 345                 350     


<210>  95
<211>  1836
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Ala Arg Pro Ser Leu Cys Thr Leu Val Pro Leu Gly Pro Glu Cys 
1               5                   10                  15      


Leu Arg Pro Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ala 
            20                  25                  30          


Val Glu Glu Glu Ala Arg Leu Gln Arg Asn Lys Gln Met Glu Ile Glu 
        35                  40                  45              


Glu Pro Glu Arg Lys Pro Arg Ser Asp Leu Glu Ala Gly Lys Asn Leu 
    50                  55                  60                  


Pro Met Ile Tyr Gly Asp Pro Pro Pro Glu Val Ile Gly Ile Pro Leu 
65                  70                  75                  80  


Glu Asp Leu Asp Pro Tyr Tyr Ser Asn Lys Lys Thr Phe Ile Val Leu 
                85                  90                  95      


Asn Lys Gly Lys Ala Ile Phe Arg Phe Ser Ala Thr Pro Ala Leu Tyr 
            100                 105                 110         


Leu Leu Ser Pro Phe Ser Val Val Arg Arg Gly Ala Ile Lys Val Leu 
        115                 120                 125             


Ile His Ala Leu Phe Ser Met Phe Ile Met Ile Thr Ile Leu Thr Asn 
    130                 135                 140                 


Cys Val Phe Met Thr Met Ser Asp Pro Pro Pro Trp Ser Lys Asn Val 
145                 150                 155                 160 


Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile 
                165                 170                 175     


Leu Ala Arg Gly Phe Cys Val Asp Asp Phe Thr Phe Leu Arg Asp Pro 
            180                 185                 190         


Trp Asn Trp Leu Asp Phe Ser Val Ile Met Met Ala Tyr Leu Thr Glu 
        195                 200                 205             


Phe Val Asp Leu Gly Asn Ile Ser Ala Leu Arg Thr Phe Arg Val Leu 
    210                 215                 220                 


Arg Ala Leu Lys Thr Ile Thr Val Ile Pro Gly Leu Lys Thr Ile Val 
225                 230                 235                 240 


Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu 
                245                 250                 255     


Thr Val Phe Cys Leu Ser Val Phe Ala Leu Val Gly Leu Gln Leu Phe 
            260                 265                 270         


Met Gly Asn Leu Arg Gln Lys Cys Val Arg Trp Pro Pro Pro Phe Asn 
        275                 280                 285             


Asp Thr Asn Thr Thr Trp Tyr Ser Asn Asp Thr Trp Tyr Gly Asn Asp 
    290                 295                 300                 


Thr Trp Tyr Gly Asn Glu Met Trp Tyr Gly Asn Asp Ser Trp Tyr Ala 
305                 310                 315                 320 


Asn Asp Thr Trp Asn Ser His Ala Ser Trp Ala Thr Asn Asp Thr Phe 
                325                 330                 335     


Asp Trp Asp Ala Tyr Ile Ser Asp Glu Gly Asn Phe Tyr Phe Leu Glu 
            340                 345                 350         


Gly Ser Asn Asp Ala Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly His 
        355                 360                 365             


Cys Pro Glu Gly Tyr Glu Cys Ile Lys Thr Gly Arg Asn Pro Asn Tyr 
    370                 375                 380                 


Gly Tyr Thr Ser Tyr Asp Thr Phe Ser Trp Ala Phe Leu Ala Leu Phe 
385                 390                 395                 400 


Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Phe Gln Leu Thr Leu 
                405                 410                 415     


Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val Ile Ile Phe 
            420                 425                 430         


Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val Val Ala Met 
        435                 440                 445             


Ala Tyr Ala Glu Gln Asn Glu Ala Thr Leu Ala Glu Asp Lys Glu Lys 
    450                 455                 460                 


Glu Glu Glu Phe Gln Gln Met Leu Glu Lys Phe Lys Lys His Gln Glu 
465                 470                 475                 480 


Glu Leu Glu Lys Ala Lys Ala Ala Gln Ala Leu Glu Gly Gly Glu Ala 
                485                 490                 495     


Asp Gly Asp Pro Ala His Gly Lys Asp Cys Asn Gly Ser Leu Asp Thr 
            500                 505                 510         


Ser Gln Gly Glu Lys Gly Ala Pro Arg Gln Ser Ser Ser Gly Asp Ser 
        515                 520                 525             


Gly Ile Ser Asp Ala Met Glu Glu Leu Glu Glu Ala His Gln Lys Cys 
    530                 535                 540                 


Pro Pro Trp Trp Tyr Lys Cys Ala His Lys Val Leu Ile Trp Asn Cys 
545                 550                 555                 560 


Cys Ala Pro Trp Leu Lys Phe Lys Asn Ile Ile His Leu Ile Val Met 
                565                 570                 575     


Asp Pro Phe Val Asp Leu Gly Ile Thr Ile Cys Ile Val Leu Asn Thr 
            580                 585                 590         


Leu Phe Met Ala Met Glu His Tyr Pro Met Thr Glu His Phe Asp Asn 
        595                 600                 605             


Val Leu Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu 
    610                 615                 620                 


Met Val Leu Lys Leu Ile Ala Met Asp Pro Tyr Glu Tyr Phe Gln Gln 
625                 630                 635                 640 


Gly Trp Asn Ile Phe Asp Ser Ile Ile Val Thr Leu Ser Leu Val Glu 
                645                 650                 655     


Leu Gly Leu Ala Asn Val Gln Gly Leu Ser Val Leu Arg Ser Phe Arg 
            660                 665                 670         


Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met 
        675                 680                 685             


Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr 
    690                 695                 700                 


Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln 
705                 710                 715                 720 


Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys Lys Ile Ala Leu Asp 
                725                 730                 735     


Cys Asn Leu Pro Arg Trp His Met His Asp Phe Phe His Ser Phe Leu 
            740                 745                 750         


Ile Val Phe Arg Ile Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp 
        755                 760                 765             


Cys Met Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Leu Met 
    770                 775                 780                 


Val Met Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu 
785                 790                 795                 800 


Leu Leu Ser Ser Phe Ser Ala Asp Ser Leu Ala Ala Ser Asp Glu Asp 
                805                 810                 815     


Gly Glu Met Asn Asn Leu Gln Ile Ala Ile Gly Arg Ile Lys Leu Gly 
            820                 825                 830         


Ile Gly Phe Ala Lys Ala Phe Leu Leu Gly Leu Leu His Gly Lys Ile 
        835                 840                 845             


Leu Ser Pro Lys Asp Ile Met Leu Ser Leu Gly Glu Ala Asp Gly Ala 
    850                 855                 860                 


Gly Glu Ala Gly Glu Ala Gly Glu Thr Ala Pro Glu Asp Glu Lys Lys 
865                 870                 875                 880 


Glu Pro Pro Glu Glu Asp Leu Lys Lys Asp Asn His Ile Leu Asn His 
                885                 890                 895     


Met Gly Leu Ala Asp Gly Pro Pro Ser Ser Leu Glu Leu Asp His Leu 
            900                 905                 910         


Asn Phe Ile Asn Asn Pro Tyr Leu Thr Ile Gln Val Pro Ile Ala Ser 
        915                 920                 925             


Glu Glu Ser Asp Leu Glu Met Pro Thr Glu Glu Glu Thr Asp Thr Phe 
    930                 935                 940                 


Ser Glu Pro Glu Asp Ser Lys Lys Pro Pro Gln Pro Leu Tyr Asp Gly 
945                 950                 955                 960 


Asn Ser Ser Val Cys Ser Thr Ala Asp Tyr Lys Pro Pro Glu Glu Asp 
                965                 970                 975     


Pro Glu Glu Gln Ala Glu Glu Asn Pro Glu Gly Glu Gln Pro Glu Glu 
            980                 985                 990         


Cys Phe Thr Glu Ala Cys Val Gln  Arg Trp Pro Cys Leu  Tyr Val Asp 
        995                 1000                 1005             


Ile Ser  Gln Gly Arg Gly Lys  Lys Trp Trp Thr Leu  Arg Arg Ala 
    1010                 1015                 1020             


Cys Phe  Lys Ile Val Glu His  Asn Trp Phe Glu Thr  Phe Ile Val 
    1025                 1030                 1035             


Phe Met  Ile Leu Leu Ser Ser  Gly Ala Leu Ala Phe  Glu Asp Ile 
    1040                 1045                 1050             


Tyr Ile  Glu Gln Arg Arg Val  Ile Arg Thr Ile Leu  Glu Tyr Ala 
    1055                 1060                 1065             


Asp Lys  Val Phe Thr Tyr Ile  Phe Ile Met Glu Met  Leu Leu Lys 
    1070                 1075                 1080             


Trp Val  Ala Tyr Gly Phe Lys  Val Tyr Phe Thr Asn  Ala Trp Cys 
    1085                 1090                 1095             


Trp Leu  Asp Phe Leu Ile Val  Asp Val Ser Ile Ile  Ser Leu Val 
    1100                 1105                 1110             


Ala Asn  Trp Leu Gly Tyr Ser  Glu Leu Gly Pro Ile  Lys Ser Leu 
    1115                 1120                 1125             


Arg Thr  Leu Arg Ala Leu Arg  Pro Leu Arg Ala Leu  Ser Arg Phe 
    1130                 1135                 1140             


Glu Gly  Met Arg Val Val Val  Asn Ala Leu Leu Gly  Ala Ile Pro 
    1145                 1150                 1155             


Ser Ile  Met Asn Val Leu Leu  Val Cys Leu Ile Phe  Trp Leu Ile 
    1160                 1165                 1170             


Phe Ser  Ile Met Gly Val Asn  Leu Phe Ala Gly Lys  Phe Tyr Tyr 
    1175                 1180                 1185             


Cys Ile  Asn Thr Thr Thr Ser  Glu Arg Phe Asp Ile  Ser Glu Val 
    1190                 1195                 1200             


Asn Asn  Lys Ser Glu Cys Glu  Ser Leu Met His Thr  Gly Gln Val 
    1205                 1210                 1215             


Arg Trp  Leu Asn Val Lys Val  Asn Tyr Asp Asn Val  Gly Leu Gly 
    1220                 1225                 1230             


Tyr Leu  Ser Leu Leu Gln Val  Ala Thr Phe Lys Gly  Trp Met Asp 
    1235                 1240                 1245             


Ile Met  Tyr Ala Ala Val Asp  Ser Arg Glu Lys Glu  Glu Gln Pro 
    1250                 1255                 1260             


Gln Tyr  Glu Val Asn Leu Tyr  Met Tyr Leu Tyr Phe  Val Ile Phe 
    1265                 1270                 1275             


Ile Ile  Phe Gly Ser Phe Phe  Thr Leu Asn Leu Phe  Ile Gly Val 
    1280                 1285                 1290             


Ile Ile  Asp Asn Phe Asn Gln  Gln Lys Lys Lys Leu  Gly Gly Lys 
    1295                 1300                 1305             


Asp Ile  Phe Met Thr Glu Glu  Gln Lys Lys Tyr Tyr  Asn Ala Met 
    1310                 1315                 1320             


Lys Lys  Leu Gly Ser Lys Lys  Pro Gln Lys Pro Ile  Pro Arg Pro 
    1325                 1330                 1335             


Gln Asn  Lys Ile Gln Gly Met  Val Tyr Asp Leu Val  Thr Lys Gln 
    1340                 1345                 1350             


Ala Phe  Asp Ile Thr Ile Met  Ile Leu Ile Cys Leu  Asn Met Val 
    1355                 1360                 1365             


Thr Met  Met Val Glu Thr Asp  Asn Gln Ser Gln Leu  Lys Val Asp 
    1370                 1375                 1380             


Ile Leu  Tyr Asn Ile Asn Met  Ile Phe Ile Ile Ile  Phe Thr Gly 
    1385                 1390                 1395             


Glu Cys  Val Leu Lys Met Leu  Ala Leu Arg Gln Tyr  Tyr Phe Thr 
    1400                 1405                 1410             


Val Gly  Trp Asn Ile Phe Asp  Phe Val Val Val Ile  Leu Ser Ile 
    1415                 1420                 1425             


Val Gly  Leu Ala Leu Ser Asp  Leu Ile Gln Lys Tyr  Phe Val Ser 
    1430                 1435                 1440             


Pro Thr  Leu Phe Arg Val Ile  Arg Leu Ala Arg Ile  Gly Arg Val 
    1445                 1450                 1455             


Leu Arg  Leu Ile Arg Gly Ala  Lys Gly Ile Arg Thr  Leu Leu Phe 
    1460                 1465                 1470             


Ala Leu  Met Met Ser Leu Pro  Ala Leu Phe Asn Ile  Gly Leu Leu 
    1475                 1480                 1485             


Leu Phe  Leu Val Met Phe Ile  Tyr Ser Ile Phe Gly  Met Ser Asn 
    1490                 1495                 1500             


Phe Ala  Tyr Val Lys Lys Glu  Ser Gly Ile Asp Asp  Met Phe Asn 
    1505                 1510                 1515             


Phe Glu  Thr Phe Gly Asn Ser  Ile Ile Cys Leu Phe  Glu Ile Thr 
    1520                 1525                 1530             


Thr Ser  Ala Gly Trp Asp Gly  Leu Leu Asn Pro Ile  Leu Asn Ser 
    1535                 1540                 1545             


Gly Pro  Pro Asp Cys Asp Pro  Asn Leu Glu Asn Pro  Gly Thr Ser 
    1550                 1555                 1560             


Val Lys  Gly Asp Cys Gly Asn  Pro Ser Ile Gly Ile  Cys Phe Phe 
    1565                 1570                 1575             


Cys Ser  Tyr Ile Ile Ile Ser  Phe Leu Ile Val Val  Asn Met Tyr 
    1580                 1585                 1590             


Ile Ala  Ile Ile Leu Glu Asn  Phe Asn Val Ala Thr  Glu Glu Ser 
    1595                 1600                 1605             


Ser Glu  Pro Leu Gly Glu Asp  Asp Phe Glu Met Phe  Tyr Glu Thr 
    1610                 1615                 1620             


Trp Glu  Lys Phe Asp Pro Asp  Ala Thr Gln Phe Ile  Ala Tyr Ser 
    1625                 1630                 1635             


Arg Leu  Ser Asp Phe Val Asp  Thr Leu Gln Glu Pro  Leu Arg Ile 
    1640                 1645                 1650             


Ala Lys  Pro Asn Lys Ile Lys  Leu Ile Thr Leu Asp  Leu Pro Met 
    1655                 1660                 1665             


Val Pro  Gly Asp Lys Ile His  Cys Leu Asp Ile Leu  Phe Ala Leu 
    1670                 1675                 1680             


Thr Lys  Glu Val Leu Gly Asp  Ser Gly Glu Met Asp  Ala Leu Lys 
    1685                 1690                 1695             


Gln Thr  Met Glu Glu Lys Phe  Met Ala Ala Asn Pro  Ser Lys Val 
    1700                 1705                 1710             


Ser Tyr  Glu Pro Ile Thr Thr  Thr Leu Lys Arg Lys  His Glu Glu 
    1715                 1720                 1725             


Val Cys  Ala Ile Lys Ile Gln  Arg Ala Tyr Arg Arg  His Leu Leu 
    1730                 1735                 1740             


Gln Arg  Ser Met Lys Gln Ala  Ser Tyr Met Tyr Arg  His Ser His 
    1745                 1750                 1755             


Asp Gly  Ser Gly Asp Asp Ala  Pro Glu Lys Glu Gly  Leu Leu Ala 
    1760                 1765                 1770             


Asn Thr  Met Ser Lys Met Tyr  Gly His Glu Asn Gly  Asn Ser Ser 
    1775                 1780                 1785             


Ser Pro  Ser Pro Glu Glu Lys  Gly Glu Ala Gly Asp  Ala Gly Pro 
    1790                 1795                 1800             


Thr Met  Gly Leu Met Pro Ile  Ser Pro Ser Asp Thr  Ala Trp Pro 
    1805                 1810                 1815             


Pro Ala  Pro Pro Pro Gly Gln  Thr Val Arg Pro Gly  Val Lys Glu 
    1820                 1825                 1830             


Ser Leu  Val 
    1835     


<210>  96
<211>  640
<212>  PRT
<213>  Homo sapiens

<400>  96

Met His Val Lys Lys Tyr Leu Leu Lys Gly Leu His Arg Leu Gln Lys 
1               5                   10                  15      


Gly Pro Gly Tyr Thr Tyr Lys Glu Leu Leu Val Trp Tyr Cys Asp Asn 
            20                  25                  30          


Thr Asn Thr His Gly Pro Lys Arg Ile Ile Cys Glu Gly Pro Lys Lys 
        35                  40                  45              


Lys Ala Met Trp Phe Leu Leu Thr Leu Leu Phe Ala Ala Leu Val Cys 
    50                  55                  60                  


Trp Gln Trp Gly Ile Phe Ile Arg Thr Tyr Leu Ser Trp Glu Val Ser 
65                  70                  75                  80  


Val Ser Leu Ser Val Gly Phe Lys Thr Met Asp Phe Pro Ala Val Thr 
                85                  90                  95      


Ile Cys Asn Ala Ser Pro Phe Lys Tyr Ser Lys Ile Lys His Leu Leu 
            100                 105                 110         


Lys Asp Leu Asp Glu Leu Met Glu Ala Val Leu Glu Arg Ile Leu Ala 
        115                 120                 125             


Pro Glu Leu Ser His Ala Asn Ala Thr Arg Asn Leu Asn Phe Ser Ile 
    130                 135                 140                 


Trp Asn His Thr Pro Leu Val Leu Ile Asp Glu Arg Asn Pro His His 
145                 150                 155                 160 


Pro Met Val Leu Asp Leu Phe Gly Asp Asn His Asn Gly Leu Thr Ser 
                165                 170                 175     


Ser Ser Ala Ser Glu Lys Ile Cys Asn Ala His Gly Cys Lys Met Ala 
            180                 185                 190         


Met Arg Leu Cys Ser Leu Asn Arg Thr Gln Cys Thr Phe Arg Asn Phe 
        195                 200                 205             


Thr Ser Ala Thr Gln Ala Leu Thr Glu Trp Tyr Ile Leu Gln Ala Thr 
    210                 215                 220                 


Asn Ile Phe Ala Gln Val Pro Gln Gln Glu Leu Val Glu Met Ser Tyr 
225                 230                 235                 240 


Pro Gly Glu Gln Met Ile Leu Ala Cys Leu Phe Gly Ala Glu Pro Cys 
                245                 250                 255     


Asn Tyr Arg Asn Phe Thr Ser Ile Phe Tyr Pro His Tyr Gly Asn Cys 
            260                 265                 270         


Tyr Ile Phe Asn Trp Gly Met Thr Glu Lys Ala Leu Pro Ser Ala Asn 
        275                 280                 285             


Pro Gly Thr Glu Phe Gly Leu Lys Leu Ile Leu Asp Ile Gly Gln Glu 
    290                 295                 300                 


Asp Tyr Val Pro Phe Leu Ala Ser Thr Ala Gly Val Arg Leu Met Leu 
305                 310                 315                 320 


His Glu Gln Arg Ser Tyr Pro Phe Ile Arg Asp Glu Gly Ile Tyr Ala 
                325                 330                 335     


Met Ser Gly Thr Glu Thr Ser Ile Gly Val Leu Val Asp Lys Leu Gln 
            340                 345                 350         


Arg Met Gly Glu Pro Tyr Ser Pro Cys Thr Val Asn Gly Ser Glu Val 
        355                 360                 365             


Pro Val Gln Asn Phe Tyr Ser Asp Tyr Asn Thr Thr Tyr Ser Ile Gln 
    370                 375                 380                 


Ala Cys Leu Arg Ser Cys Phe Gln Asp His Met Ile Arg Asn Cys Asn 
385                 390                 395                 400 


Cys Gly His Tyr Leu Tyr Pro Leu Pro Arg Gly Glu Lys Tyr Cys Asn 
                405                 410                 415     


Asn Arg Asp Phe Pro Asp Trp Ala His Cys Tyr Ser Asp Leu Gln Met 
            420                 425                 430         


Ser Val Ala Gln Arg Glu Thr Cys Ile Gly Met Cys Lys Glu Ser Cys 
        435                 440                 445             


Asn Asp Thr Gln Tyr Lys Met Thr Ile Ser Met Ala Asp Trp Pro Ser 
    450                 455                 460                 


Glu Ala Ser Glu Asp Trp Ile Phe His Val Leu Ser Gln Glu Arg Asp 
465                 470                 475                 480 


Gln Ser Thr Asn Ile Thr Leu Ser Arg Lys Gly Ile Val Lys Leu Asn 
                485                 490                 495     


Ile Tyr Phe Gln Glu Phe Asn Tyr Arg Thr Ile Glu Glu Ser Ala Ala 
            500                 505                 510         


Asn Asn Ile Val Trp Leu Leu Ser Asn Leu Gly Gly Gln Phe Gly Phe 
        515                 520                 525             


Trp Met Gly Gly Ser Val Leu Cys Leu Ile Glu Phe Gly Glu Ile Ile 
    530                 535                 540                 


Ile Asp Phe Val Trp Ile Thr Ile Ile Lys Leu Val Ala Leu Ala Lys 
545                 550                 555                 560 


Ser Leu Arg Gln Arg Arg Ala Gln Ala Ser Tyr Ala Gly Pro Pro Pro 
                565                 570                 575     


Thr Val Ala Glu Leu Val Glu Ala His Thr Asn Phe Gly Phe Gln Pro 
            580                 585                 590         


Asp Thr Ala Pro Arg Ser Pro Asn Thr Gly Pro Tyr Pro Ser Glu Gln 
        595                 600                 605             


Ala Leu Pro Ile Pro Gly Thr Pro Pro Pro Asn Tyr Asp Ser Leu Arg 
    610                 615                 620                 


Leu Gln Pro Leu Asp Val Ile Glu Ser Asp Ser Glu Gly Asp Ala Ile 
625                 630                 635                 640 


<210>  97
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Met Pro Gln Glu Gln Tyr Thr His His Arg Ser Thr Met Pro Gly 
1               5                   10                  15      


Ser Val Gly Pro Gln Val Tyr Lys Val Gly Ile Tyr Gly Trp Arg Lys 
            20                  25                  30          


Arg Cys Leu Tyr Phe Phe Val Leu Leu Leu Met Ile Leu Ile Leu Val 
        35                  40                  45              


Asn Leu Ala Met Thr Ile Trp Ile Leu Lys Val Met Asn Phe Thr Ile 
    50                  55                  60                  


Asp Gly Met Gly Asn Leu Arg Ile Thr Glu Lys Gly Leu Lys Leu Glu 
65                  70                  75                  80  


Gly Asp Ser Glu Phe Leu Gln Pro Leu Tyr Ala Lys Glu Ile Gln Ser 
                85                  90                  95      


Arg Pro Gly Asn Ala Leu Tyr Phe Lys Ser Ala Arg Asn Val Thr Val 
            100                 105                 110         


Asn Ile Leu Asn Asp Gln Thr Lys Val Leu Thr Gln Leu Ile Thr Gly 
        115                 120                 125             


Pro Lys Ala Val Glu Ala Tyr Gly Lys Lys Phe Glu Val Lys Thr Val 
    130                 135                 140                 


Ser Gly Lys Leu Leu Phe Ser Ala Asp Asn Asn Glu Val Val Val Gly 
145                 150                 155                 160 


Ala Glu Arg Leu Arg Val Leu Gly Ala Glu Gly Thr Val Phe Pro Lys 
                165                 170                 175     


Ser Ile Glu Thr Pro Asn Val Arg Ala Asp Pro Phe Lys Glu Leu Arg 
            180                 185                 190         


Leu Glu Ser Pro Thr Arg Ser Leu Val Met Glu Ala Pro Lys Gly Val 
        195                 200                 205             


Glu Ile Asn Ala Glu Ala Gly Asn Met Glu Ala Thr Cys Arg Thr Glu 
    210                 215                 220                 


Leu Arg Leu Glu Ser Lys Asp Gly Glu Ile Lys Leu Asp Ala Ala Lys 
225                 230                 235                 240 


Ile Arg Leu Pro Arg Leu Pro His Gly Ser Tyr Thr Pro Thr Gly Thr 
                245                 250                 255     


Arg Gln Lys Val Phe Glu Ile Cys Val Cys Ala Asn Gly Arg Leu Phe 
            260                 265                 270         


Leu Ser Gln Ala Gly Ala Gly Ser Thr Cys Gln Ile Asn Thr Ser Val 
        275                 280                 285             


Cys Leu 
    290 


<210>  98
<211>  1099
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Ser Leu Asn Asn Ser Ser Asn Val Phe Leu Asp Ser Val Pro Ser 
1               5                   10                  15      


Asn Thr Asn Arg Phe Gln Val Ser Val Ile Asn Glu Asn His Glu Ser 
            20                  25                  30          


Ser Ala Ala Ala Asp Asp Asn Thr Asp Pro Pro His Tyr Glu Glu Thr 
        35                  40                  45              


Ser Phe Gly Asp Glu Ala Gln Lys Arg Leu Arg Ile Ser Phe Arg Pro 
    50                  55                  60                  


Gly Asn Gln Glu Cys Tyr Asp Asn Phe Leu Gln Ser Gly Glu Thr Ala 
65                  70                  75                  80  


Lys Thr Asp Ala Ser Phe His Ala Tyr Asp Ser His Thr Asn Thr Tyr 
                85                  90                  95      


Tyr Leu Gln Thr Phe Gly His Asn Thr Met Asp Ala Val Pro Lys Ile 
            100                 105                 110         


Glu Tyr Tyr Arg Asn Thr Gly Ser Ile Ser Gly Pro Lys Val Asn Arg 
        115                 120                 125             


Pro Ser Leu Leu Glu Ile His Glu Gln Leu Ala Lys Asn Val Ala Val 
    130                 135                 140                 


Thr Pro Ser Ser Ala Asp Arg Val Ala Asn Gly Asp Gly Ile Pro Gly 
145                 150                 155                 160 


Asp Glu Gln Ala Glu Asn Lys Glu Asp Asp Gln Ala Gly Val Val Lys 
                165                 170                 175     


Phe Gly Trp Val Lys Gly Val Leu Val Arg Cys Met Leu Asn Ile Trp 
            180                 185                 190         


Gly Val Met Leu Phe Ile Arg Leu Ser Trp Ile Val Gly Glu Ala Gly 
        195                 200                 205             


Ile Gly Leu Gly Val Leu Ile Ile Leu Leu Ser Thr Met Val Thr Ser 
    210                 215                 220                 


Ile Thr Gly Leu Ser Thr Ser Ala Ile Ala Thr Asn Gly Phe Val Arg 
225                 230                 235                 240 


Gly Gly Gly Ala Tyr Tyr Leu Ile Ser Arg Ser Leu Gly Pro Glu Phe 
                245                 250                 255     


Gly Gly Ser Ile Gly Leu Ile Phe Ala Phe Ala Asn Ala Val Ala Val 
            260                 265                 270         


Ala Met Tyr Val Val Gly Phe Ala Glu Thr Val Val Asp Leu Leu Lys 
        275                 280                 285             


Glu Ser Asp Ser Met Met Val Asp Pro Thr Asn Asp Ile Arg Ile Ile 
    290                 295                 300                 


Gly Ser Ile Thr Val Val Ile Leu Leu Gly Ile Ser Val Ala Gly Met 
305                 310                 315                 320 


Glu Trp Glu Ala Lys Ala Gln Val Ile Leu Leu Val Ile Leu Leu Ile 
                325                 330                 335     


Ala Ile Ala Asn Phe Phe Ile Gly Thr Val Ile Pro Ser Asn Asn Glu 
            340                 345                 350         


Lys Lys Ser Arg Gly Phe Phe Asn Tyr Gln Ala Ser Ile Phe Ala Glu 
        355                 360                 365             


Asn Phe Gly Pro Arg Phe Thr Lys Gly Glu Gly Phe Phe Ser Val Phe 
    370                 375                 380                 


Ala Ile Phe Phe Pro Ala Ala Thr Gly Ile Leu Ala Gly Ala Asn Ile 
385                 390                 395                 400 


Ser Gly Asp Leu Glu Asp Pro Gln Asp Ala Ile Pro Arg Gly Thr Met 
                405                 410                 415     


Leu Ala Ile Phe Ile Thr Thr Val Ala Tyr Leu Gly Val Ala Ile Cys 
            420                 425                 430         


Val Gly Ala Cys Val Val Arg Asp Ala Thr Gly Asn Met Asn Asp Thr 
        435                 440                 445             


Ile Ile Ser Gly Met Asn Cys Asn Gly Ser Ala Ala Cys Gly Leu Gly 
    450                 455                 460                 


Tyr Asp Phe Ser Arg Cys Arg His Glu Pro Cys Gln Tyr Gly Leu Met 
465                 470                 475                 480 


Asn Asn Phe Gln Val Met Ser Met Val Ser Gly Phe Gly Pro Leu Ile 
                485                 490                 495     


Thr Ala Gly Ile Phe Ser Ala Thr Leu Ser Ser Ala Leu Ala Ser Leu 
            500                 505                 510         


Val Ser Ala Pro Lys Val Phe Gln Ala Leu Cys Lys Asp Asn Ile Tyr 
        515                 520                 525             


Lys Ala Leu Gln Phe Phe Ala Lys Gly Tyr Gly Lys Asn Asn Glu Pro 
    530                 535                 540                 


Leu Arg Gly Tyr Ile Leu Thr Phe Leu Ile Ala Met Ala Phe Ile Leu 
545                 550                 555                 560 


Ile Ala Glu Leu Asn Thr Ile Ala Pro Ile Ile Ser Asn Phe Phe Leu 
                565                 570                 575     


Ala Ser Tyr Ala Leu Ile Asn Phe Ser Cys Phe His Ala Ser Tyr Ala 
            580                 585                 590         


Lys Ser Pro Gly Trp Arg Pro Ala Tyr Gly Ile Tyr Asn Met Trp Val 
        595                 600                 605             


Ser Leu Phe Gly Ala Val Leu Cys Cys Ala Val Met Phe Val Ile Asn 
    610                 615                 620                 


Trp Trp Ala Ala Val Ile Thr Tyr Val Ile Glu Phe Phe Leu Tyr Val 
625                 630                 635                 640 


Tyr Val Thr Cys Lys Lys Pro Asp Val Asn Trp Gly Ser Ser Thr Gln 
                645                 650                 655     


Ala Leu Ser Tyr Val Ser Ala Leu Asp Asn Ala Leu Glu Leu Thr Thr 
            660                 665                 670         


Val Glu Asp His Val Lys Asn Phe Arg Pro Gln Cys Ile Val Leu Thr 
        675                 680                 685             


Gly Gly Pro Met Thr Arg Pro Ala Leu Leu Asp Ile Thr His Ala Phe 
    690                 695                 700                 


Thr Lys Asn Ser Gly Leu Cys Ile Cys Cys Glu Val Phe Val Gly Pro 
705                 710                 715                 720 


Arg Lys Leu Cys Val Lys Glu Met Asn Ser Gly Met Ala Lys Lys Gln 
                725                 730                 735     


Ala Trp Leu Ile Lys Asn Lys Ile Lys Ala Phe Tyr Ala Ala Val Ala 
            740                 745                 750         


Ala Asp Cys Phe Arg Asp Gly Val Arg Ser Leu Leu Gln Ala Ser Gly 
        755                 760                 765             


Leu Gly Arg Met Lys Pro Asn Thr Leu Val Ile Gly Tyr Lys Lys Asn 
    770                 775                 780                 


Trp Arg Lys Ala Pro Leu Thr Glu Ile Glu Asn Tyr Val Gly Ile Ile 
785                 790                 795                 800 


His Asp Ala Phe Asp Phe Glu Ile Gly Val Val Ile Val Arg Ile Ser 
                805                 810                 815     


Gln Gly Phe Asp Ile Ser Gln Val Leu Gln Val Gln Glu Glu Leu Glu 
            820                 825                 830         


Arg Leu Glu Gln Glu Arg Leu Ala Leu Glu Ala Thr Ile Lys Asp Asn 
        835                 840                 845             


Glu Cys Glu Glu Glu Ser Gly Gly Ile Arg Gly Leu Phe Lys Lys Ala 
    850                 855                 860                 


Gly Lys Leu Asn Ile Thr Lys Thr Thr Pro Lys Lys Asp Gly Ser Ile 
865                 870                 875                 880 


Asn Thr Ser Gln Ser Met His Val Gly Glu Phe Asn Gln Lys Leu Val 
                885                 890                 895     


Glu Ala Ser Thr Gln Phe Lys Lys Lys Gln Glu Lys Gly Thr Ile Asp 
            900                 905                 910         


Val Trp Trp Leu Phe Asp Asp Gly Gly Leu Thr Leu Leu Ile Pro Tyr 
        915                 920                 925             


Ile Leu Thr Leu Arg Lys Lys Trp Lys Asp Cys Lys Leu Arg Ile Tyr 
    930                 935                 940                 


Val Gly Gly Lys Ile Asn Arg Ile Glu Glu Glu Lys Ile Val Met Ala 
945                 950                 955                 960 


Ser Leu Leu Ser Lys Phe Arg Ile Lys Phe Ala Asp Ile His Ile Ile 
                965                 970                 975     


Gly Asp Ile Asn Ile Arg Pro Asn Lys Glu Ser Trp Lys Val Phe Glu 
            980                 985                 990         


Glu Met Ile Glu Pro Tyr Arg Leu  His Glu Ser Cys Lys  Asp Leu Thr 
        995                 1000                 1005             


Thr Ala  Glu Lys Leu Lys Arg  Glu Thr Pro Trp Lys  Ile Thr Asp 
    1010                 1015                 1020             


Ala Glu  Leu Glu Ala Val Lys  Glu Lys Ser Tyr Arg  Gln Val Arg 
    1025                 1030                 1035             


Leu Asn  Glu Leu Leu Gln Glu  His Ser Arg Ala Ala  Asn Leu Ile 
    1040                 1045                 1050             


Val Leu  Ser Leu Pro Val Ala  Arg Lys Gly Ser Ile  Ser Asp Leu 
    1055                 1060                 1065             


Leu Tyr  Met Ala Trp Leu Glu  Ile Leu Thr Lys Asn  Leu Pro Pro 
    1070                 1075                 1080             


Val Leu  Leu Val Arg Gly Asn  His Lys Asn Val Leu  Thr Phe Tyr 
    1085                 1090                 1095             


Ser 
    


<210>  99
<211>  1030
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Ala Glu Leu Pro Thr Thr Glu Thr Pro Gly Asp Ala Thr Leu Cys 
1               5                   10                  15      


Ser Gly Arg Phe Thr Ile Ser Thr Leu Leu Ser Ser Asp Glu Pro Ser 
            20                  25                  30          


Pro Pro Ala Ala Tyr Asp Ser Ser His Pro Ser His Leu Thr His Ser 
        35                  40                  45              


Ser Thr Phe Cys Met Arg Thr Phe Gly Tyr Asn Thr Ile Asp Val Val 
    50                  55                  60                  


Pro Thr Tyr Glu His Tyr Ala Asn Ser Thr Gln Pro Gly Glu Pro Arg 
65                  70                  75                  80  


Lys Val Arg Pro Thr Leu Ala Asp Leu His Ser Phe Leu Lys Gln Glu 
                85                  90                  95      


Gly Arg His Leu His Ala Leu Ala Phe Asp Ser Arg Pro Ser His Glu 
            100                 105                 110         


Met Thr Asp Gly Leu Val Glu Gly Glu Ala Gly Thr Ser Ser Glu Lys 
        115                 120                 125             


Asn Pro Glu Glu Pro Val Arg Phe Gly Trp Val Lys Gly Val Met Ile 
    130                 135                 140                 


Arg Cys Met Leu Asn Ile Trp Gly Val Ile Leu Tyr Leu Arg Leu Pro 
145                 150                 155                 160 


Trp Ile Thr Ala Gln Ala Gly Ile Val Leu Thr Trp Ile Ile Ile Leu 
                165                 170                 175     


Leu Ser Val Thr Val Thr Ser Ile Thr Gly Leu Ser Ile Ser Ala Ile 
            180                 185                 190         


Ser Thr Asn Gly Lys Val Lys Ser Gly Gly Thr Tyr Phe Leu Ile Ser 
        195                 200                 205             


Arg Ser Leu Gly Pro Glu Leu Gly Gly Ser Ile Gly Leu Ile Phe Ala 
    210                 215                 220                 


Phe Ala Asn Ala Val Gly Val Ala Met His Thr Val Gly Phe Ala Glu 
225                 230                 235                 240 


Thr Val Arg Asp Leu Leu Gln Glu Tyr Gly Ala Pro Ile Val Asp Pro 
                245                 250                 255     


Ile Asn Asp Ile Arg Ile Ile Gly Val Val Ser Val Thr Val Leu Leu 
            260                 265                 270         


Ala Ile Ser Leu Ala Gly Met Glu Trp Glu Ser Lys Ala Gln Val Leu 
        275                 280                 285             


Phe Phe Leu Val Ile Met Val Ser Phe Ala Asn Tyr Leu Val Gly Thr 
    290                 295                 300                 


Leu Ile Pro Pro Ser Glu Asp Lys Ala Ser Lys Gly Phe Phe Ser Tyr 
305                 310                 315                 320 


Arg Ala Asp Ile Phe Val Gln Asn Leu Val Pro Asp Trp Arg Gly Pro 
                325                 330                 335     


Asp Gly Thr Phe Phe Gly Met Phe Ser Ile Phe Phe Pro Ser Ala Thr 
            340                 345                 350         


Gly Ile Leu Ala Gly Ala Asn Ile Ser Gly Asp Leu Lys Asp Pro Ala 
        355                 360                 365             


Ile Ala Ile Pro Lys Gly Thr Leu Met Ala Ile Phe Trp Thr Thr Ile 
    370                 375                 380                 


Ser Tyr Leu Ala Ile Ser Ala Thr Ile Gly Ser Cys Val Val Arg Asp 
385                 390                 395                 400 


Ala Ser Gly Val Leu Asn Asp Thr Val Thr Pro Gly Trp Gly Ala Cys 
                405                 410                 415     


Glu Gly Leu Ala Cys Ser Tyr Gly Trp Asn Phe Thr Glu Cys Thr Gln 
            420                 425                 430         


Gln His Ser Cys His Tyr Gly Leu Ile Asn Tyr Tyr Gln Thr Met Ser 
        435                 440                 445             


Met Val Ser Gly Phe Ala Pro Leu Ile Thr Ala Gly Ile Phe Gly Ala 
    450                 455                 460                 


Thr Leu Ser Ser Ala Leu Ala Cys Leu Val Ser Ala Ala Lys Val Phe 
465                 470                 475                 480 


Gln Cys Leu Cys Glu Asp Gln Leu Tyr Pro Leu Ile Gly Phe Phe Gly 
                485                 490                 495     


Lys Gly Tyr Gly Lys Asn Lys Glu Pro Val Arg Gly Tyr Leu Leu Ala 
            500                 505                 510         


Tyr Ala Ile Ala Val Ala Phe Ile Ile Ile Ala Glu Leu Asn Thr Ile 
        515                 520                 525             


Ala Pro Ile Ile Ser Asn Phe Phe Leu Cys Ser Tyr Ala Leu Ile Asn 
    530                 535                 540                 


Phe Ser Cys Phe His Ala Ser Ile Thr Asn Ser Pro Gly Trp Arg Pro 
545                 550                 555                 560 


Ser Phe Gln Tyr Tyr Asn Lys Trp Ala Ala Leu Phe Gly Ala Ile Ile 
                565                 570                 575     


Ser Val Val Ile Met Phe Leu Leu Thr Trp Trp Ala Ala Leu Ile Ala 
            580                 585                 590         


Ile Gly Val Val Leu Phe Leu Leu Leu Tyr Val Ile Tyr Lys Lys Pro 
        595                 600                 605             


Glu Val Asn Trp Gly Ser Ser Val Gln Ala Gly Ser Tyr Asn Leu Ala 
    610                 615                 620                 


Leu Ser Tyr Ser Val Gly Leu Asn Glu Val Glu Asp His Ile Lys Asn 
625                 630                 635                 640 


Tyr Arg Pro Gln Cys Leu Val Leu Thr Gly Pro Pro Asn Phe Arg Pro 
                645                 650                 655     


Ala Leu Val Asp Phe Val Gly Thr Phe Thr Arg Asn Leu Ser Leu Met 
            660                 665                 670         


Ile Cys Gly His Val Leu Ile Gly Pro His Lys Gln Arg Met Pro Glu 
        675                 680                 685             


Leu Gln Leu Ile Ala Asn Gly His Thr Lys Trp Leu Asn Lys Arg Lys 
    690                 695                 700                 


Ile Lys Ala Phe Tyr Ser Asp Val Ile Ala Glu Asp Leu Arg Arg Gly 
705                 710                 715                 720 


Val Gln Ile Leu Met Gln Ala Ala Gly Leu Gly Arg Met Lys Pro Asn 
                725                 730                 735     


Ile Leu Val Val Gly Phe Lys Lys Asn Trp Gln Ser Ala His Pro Ala 
            740                 745                 750         


Thr Val Glu Asp Tyr Ile Gly Ile Leu His Asp Ala Phe Asp Phe Asn 
        755                 760                 765             


Tyr Gly Val Cys Val Met Arg Met Arg Glu Gly Leu Asn Val Ser Lys 
    770                 775                 780                 


Met Met Gln Ala His Ile Asn Pro Val Phe Asp Pro Ala Glu Asp Gly 
785                 790                 795                 800 


Lys Glu Ala Ser Ala Arg Gly Ala Arg Pro Ser Val Ser Gly Ala Leu 
                805                 810                 815     


Asp Pro Lys Ala Leu Val Lys Glu Glu Gln Ala Thr Thr Ile Phe Gln 
            820                 825                 830         


Ser Glu Gln Gly Lys Lys Thr Ile Asp Ile Tyr Trp Leu Phe Asp Asp 
        835                 840                 845             


Gly Gly Leu Thr Leu Leu Ile Pro Tyr Leu Leu Gly Arg Lys Arg Arg 
    850                 855                 860                 


Trp Ser Lys Cys Lys Ile Arg Val Phe Val Gly Gly Gln Ile Asn Arg 
865                 870                 875                 880 


Met Asp Gln Glu Arg Lys Ala Ile Ile Ser Leu Leu Ser Lys Phe Arg 
                885                 890                 895     


Leu Gly Phe His Glu Val His Ile Leu Pro Asp Ile Asn Gln Asn Pro 
            900                 905                 910         


Arg Ala Glu His Thr Lys Arg Phe Glu Asp Met Ile Ala Pro Phe Arg 
        915                 920                 925             


Leu Asn Asp Gly Phe Lys Asp Glu Ala Thr Val Asn Glu Met Arg Arg 
    930                 935                 940                 


Asp Cys Pro Trp Lys Ile Ser Asp Glu Glu Ile Thr Lys Asn Arg Val 
945                 950                 955                 960 


Lys Ser Leu Arg Gln Val Arg Leu Asn Glu Ile Val Leu Asp Tyr Ser 
                965                 970                 975     


Arg Asp Ala Ala Leu Ile Val Ile Thr Leu Pro Ile Gly Arg Lys Gly 
            980                 985                 990         


Lys Cys Pro Ser Ser Leu Tyr Met  Ala Trp Leu Glu Thr  Leu Ser Gln 
        995                 1000                 1005             


Asp Leu  Arg Pro Pro Val Ile  Leu Ile Arg Gly Asn  Gln Glu Asn 
    1010                 1015                 1020             


Val Leu  Thr Phe Tyr Cys Gln  
    1025                 1030 


<210>  100
<211>  685
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Ala Glu Asp Lys Ser Lys Arg Asp Ser Ile Glu Met Ser Met Lys 
1               5                   10                  15      


Gly Cys Gln Thr Asn Asn Gly Phe Val His Asn Glu Asp Ile Leu Glu 
            20                  25                  30          


Gln Thr Pro Asp Pro Gly Ser Ser Thr Asp Asn Leu Lys His Ser Thr 
        35                  40                  45              


Arg Gly Ile Leu Gly Ser Gln Glu Pro Asp Phe Lys Gly Val Gln Pro 
    50                  55                  60                  


Tyr Ala Gly Met Pro Lys Glu Val Leu Phe Gln Phe Ser Gly Gln Ala 
65                  70                  75                  80  


Arg Tyr Arg Ile Pro Arg Glu Ile Leu Phe Trp Leu Thr Val Ala Ser 
                85                  90                  95      


Val Leu Val Leu Ile Ala Ala Thr Ile Ala Ile Ile Ala Leu Ser Pro 
            100                 105                 110         


Lys Cys Leu Asp Trp Trp Gln Glu Gly Pro Met Tyr Gln Ile Tyr Pro 
        115                 120                 125             


Arg Ser Phe Lys Asp Ser Asn Lys Asp Gly Asn Gly Asp Leu Lys Gly 
    130                 135                 140                 


Ile Gln Asp Lys Leu Asp Tyr Ile Thr Ala Leu Asn Ile Lys Thr Val 
145                 150                 155                 160 


Trp Ile Thr Ser Phe Tyr Lys Ser Ser Leu Lys Asp Phe Arg Tyr Gly 
                165                 170                 175     


Val Glu Asp Phe Arg Glu Val Asp Pro Ile Phe Gly Thr Met Glu Asp 
            180                 185                 190         


Phe Glu Asn Leu Val Ala Ala Ile His Asp Lys Gly Leu Lys Leu Ile 
        195                 200                 205             


Ile Asp Phe Ile Pro Asn His Thr Ser Asp Lys His Ile Trp Phe Gln 
    210                 215                 220                 


Leu Ser Arg Thr Arg Thr Gly Lys Tyr Thr Asp Tyr Tyr Ile Trp His 
225                 230                 235                 240 


Asp Cys Thr His Glu Asn Gly Lys Thr Ile Pro Pro Asn Asn Trp Leu 
                245                 250                 255     


Ser Val Tyr Gly Asn Ser Ser Trp His Phe Asp Glu Val Arg Asn Gln 
            260                 265                 270         


Cys Tyr Phe His Gln Phe Met Lys Glu Gln Pro Asp Leu Asn Phe Arg 
        275                 280                 285             


Asn Pro Asp Val Gln Glu Glu Ile Lys Glu Ile Leu Arg Phe Trp Leu 
    290                 295                 300                 


Thr Lys Gly Val Asp Gly Phe Ser Leu Asp Ala Val Lys Phe Leu Leu 
305                 310                 315                 320 


Glu Ala Lys His Leu Arg Asp Glu Ile Gln Val Asn Lys Thr Gln Ile 
                325                 330                 335     


Pro Asp Thr Val Thr Gln Tyr Ser Glu Leu Tyr His Asp Phe Thr Thr 
            340                 345                 350         


Thr Gln Val Gly Met His Asp Ile Val Arg Ser Phe Arg Gln Thr Met 
        355                 360                 365             


Asp Gln Tyr Ser Thr Glu Pro Gly Arg Tyr Arg Phe Met Gly Thr Glu 
    370                 375                 380                 


Ala Tyr Ala Glu Ser Ile Asp Arg Thr Val Met Tyr Tyr Gly Leu Pro 
385                 390                 395                 400 


Phe Ile Gln Glu Ala Asp Phe Pro Phe Asn Asn Tyr Leu Ser Met Leu 
                405                 410                 415     


Asp Thr Val Ser Gly Asn Ser Val Tyr Glu Val Ile Thr Ser Trp Met 
            420                 425                 430         


Glu Asn Met Pro Glu Gly Lys Trp Pro Asn Trp Met Ile Gly Gly Pro 
        435                 440                 445             


Asp Ser Ser Arg Leu Thr Ser Arg Leu Gly Asn Gln Tyr Val Asn Val 
    450                 455                 460                 


Met Asn Met Leu Leu Phe Thr Leu Pro Gly Thr Pro Ile Thr Tyr Tyr 
465                 470                 475                 480 


Gly Glu Glu Ile Gly Met Gly Asn Ile Val Ala Ala Asn Leu Asn Glu 
                485                 490                 495     


Ser Tyr Asp Ile Asn Thr Leu Arg Ser Lys Ser Pro Met Gln Trp Asp 
            500                 505                 510         


Asn Ser Ser Asn Ala Gly Phe Ser Glu Ala Ser Asn Thr Trp Leu Pro 
        515                 520                 525             


Thr Asn Ser Asp Tyr His Thr Val Asn Val Asp Val Gln Lys Thr Gln 
    530                 535                 540                 


Pro Arg Ser Ala Leu Lys Leu Tyr Gln Asp Leu Ser Leu Leu His Ala 
545                 550                 555                 560 


Asn Glu Leu Leu Leu Asn Arg Gly Trp Phe Cys His Leu Arg Asn Asp 
                565                 570                 575     


Ser His Tyr Val Val Tyr Thr Arg Glu Leu Asp Gly Ile Asp Arg Ile 
            580                 585                 590         


Phe Ile Val Val Leu Asn Phe Gly Glu Ser Thr Leu Leu Asn Leu His 
        595                 600                 605             


Asn Met Ile Ser Gly Leu Pro Ala Lys Met Arg Ile Arg Leu Ser Thr 
    610                 615                 620                 


Asn Ser Ala Asp Lys Gly Ser Lys Val Asp Thr Ser Gly Ile Phe Leu 
625                 630                 635                 640 


Asp Lys Gly Glu Gly Leu Ile Phe Glu His Asn Thr Lys Asn Leu Leu 
                645                 650                 655     


His Arg Gln Thr Ala Phe Arg Asp Arg Cys Phe Val Ser Asn Arg Ala 
            660                 665                 670         


Cys Tyr Ser Ser Val Leu Asn Ile Leu Tyr Thr Ser Cys 
        675                 680                 685 


<210>  101
<211>  911
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Glu Glu Leu Gln Asp Asp Tyr Glu Asp Met Met Glu Glu Asn Leu 
1               5                   10                  15      


Glu Gln Glu Glu Tyr Glu Asp Pro Asp Ile Pro Glu Ser Gln Met Glu 
            20                  25                  30          


Glu Pro Ala Ala His Asp Thr Glu Ala Thr Ala Thr Asp Tyr His Thr 
        35                  40                  45              


Thr Ser His Pro Gly Thr His Lys Val Tyr Val Glu Leu Gln Glu Leu 
    50                  55                  60                  


Val Met Asp Glu Lys Asn Gln Glu Leu Arg Trp Met Glu Ala Ala Arg 
65                  70                  75                  80  


Trp Val Gln Leu Glu Glu Asn Leu Gly Glu Asn Gly Ala Trp Gly Arg 
                85                  90                  95      


Pro His Leu Ser His Leu Thr Phe Trp Ser Leu Leu Glu Leu Arg Arg 
            100                 105                 110         


Val Phe Thr Lys Gly Thr Val Leu Leu Asp Leu Gln Glu Thr Ser Leu 
        115                 120                 125             


Ala Gly Val Ala Asn Gln Leu Leu Asp Arg Phe Ile Phe Glu Asp Gln 
    130                 135                 140                 


Ile Arg Pro Gln Asp Arg Glu Glu Leu Leu Arg Ala Leu Leu Leu Lys 
145                 150                 155                 160 


His Ser His Ala Gly Glu Leu Glu Ala Leu Gly Gly Val Lys Pro Ala 
                165                 170                 175     


Val Leu Thr Arg Ser Gly Asp Pro Ser Gln Pro Leu Leu Pro Gln His 
            180                 185                 190         


Ser Ser Leu Glu Thr Gln Leu Phe Cys Glu Gln Gly Asp Gly Gly Thr 
        195                 200                 205             


Glu Gly His Ser Pro Ser Gly Ile Leu Glu Lys Ile Pro Pro Asp Ser 
    210                 215                 220                 


Glu Ala Thr Leu Val Leu Val Gly Arg Ala Asp Phe Leu Glu Gln Pro 
225                 230                 235                 240 


Val Leu Gly Phe Val Arg Leu Gln Glu Ala Ala Glu Leu Glu Ala Val 
                245                 250                 255     


Glu Leu Pro Val Pro Ile Arg Phe Leu Phe Val Leu Leu Gly Pro Glu 
            260                 265                 270         


Ala Pro His Ile Asp Tyr Thr Gln Leu Gly Arg Ala Ala Ala Thr Leu 
        275                 280                 285             


Met Ser Glu Arg Val Phe Arg Ile Asp Ala Tyr Met Ala Gln Ser Arg 
    290                 295                 300                 


Gly Glu Leu Leu His Ser Leu Glu Gly Phe Leu Asp Cys Ser Leu Val 
305                 310                 315                 320 


Leu Pro Pro Thr Asp Ala Pro Ser Glu Gln Ala Leu Leu Ser Leu Val 
                325                 330                 335     


Pro Val Gln Arg Glu Leu Leu Arg Arg Arg Tyr Gln Ser Ser Pro Ala 
            340                 345                 350         


Lys Pro Asp Ser Ser Phe Tyr Lys Gly Leu Asp Leu Asn Gly Gly Pro 
        355                 360                 365             


Asp Asp Pro Leu Gln Gln Thr Gly Gln Leu Phe Gly Gly Leu Val Arg 
    370                 375                 380                 


Asp Ile Arg Arg Arg Tyr Pro Tyr Tyr Leu Ser Asp Ile Thr Asp Ala 
385                 390                 395                 400 


Phe Ser Pro Gln Val Leu Ala Ala Val Ile Phe Ile Tyr Phe Ala Ala 
                405                 410                 415     


Leu Ser Pro Ala Ile Thr Phe Gly Gly Leu Leu Gly Glu Lys Thr Arg 
            420                 425                 430         


Asn Gln Met Gly Val Ser Glu Leu Leu Ile Ser Thr Ala Val Gln Gly 
        435                 440                 445             


Ile Leu Phe Ala Leu Leu Gly Ala Gln Pro Leu Leu Val Val Gly Phe 
    450                 455                 460                 


Ser Gly Pro Leu Leu Val Phe Glu Glu Ala Phe Phe Ser Phe Cys Glu 
465                 470                 475                 480 


Thr Asn Gly Leu Glu Tyr Ile Val Gly Arg Val Trp Ile Gly Phe Trp 
                485                 490                 495     


Leu Ile Leu Leu Val Val Leu Val Val Ala Phe Glu Gly Ser Phe Leu 
            500                 505                 510         


Val Arg Phe Ile Ser Arg Tyr Thr Gln Glu Ile Phe Ser Phe Leu Ile 
        515                 520                 525             


Ser Leu Ile Phe Ile Tyr Glu Thr Phe Ser Lys Leu Ile Lys Ile Phe 
    530                 535                 540                 


Gln Asp His Pro Leu Gln Lys Thr Tyr Asn Tyr Asn Val Leu Met Val 
545                 550                 555                 560 


Pro Lys Pro Gln Gly Pro Leu Pro Asn Thr Ala Leu Leu Ser Leu Val 
                565                 570                 575     


Leu Met Ala Gly Thr Phe Phe Phe Ala Met Met Leu Arg Lys Phe Lys 
            580                 585                 590         


Asn Ser Ser Tyr Phe Pro Gly Lys Leu Arg Arg Val Ile Gly Asp Phe 
        595                 600                 605             


Gly Val Pro Ile Ser Ile Leu Ile Met Val Leu Val Asp Phe Phe Ile 
    610                 615                 620                 


Gln Asp Thr Tyr Thr Gln Lys Leu Ser Val Pro Asp Gly Phe Lys Val 
625                 630                 635                 640 


Ser Asn Ser Ser Ala Arg Gly Trp Val Ile His Pro Leu Gly Leu Arg 
                645                 650                 655     


Ser Glu Phe Pro Ile Trp Met Met Phe Ala Ser Ala Leu Pro Ala Leu 
            660                 665                 670         


Leu Val Phe Ile Leu Ile Phe Leu Glu Ser Gln Ile Thr Thr Leu Ile 
        675                 680                 685             


Val Ser Lys Pro Glu Arg Lys Met Val Lys Gly Ser Gly Phe His Leu 
    690                 695                 700                 


Asp Leu Leu Leu Val Val Gly Met Gly Gly Val Ala Ala Leu Phe Gly 
705                 710                 715                 720 


Met Pro Trp Leu Ser Ala Thr Thr Val Arg Ser Val Thr His Ala Asn 
                725                 730                 735     


Ala Leu Thr Val Met Gly Lys Ala Ser Thr Pro Gly Ala Ala Ala Gln 
            740                 745                 750         


Ile Gln Glu Val Lys Glu Gln Arg Ile Ser Gly Leu Leu Val Ala Val 
        755                 760                 765             


Leu Val Gly Leu Ser Ile Leu Met Glu Pro Ile Leu Ser Arg Ile Pro 
    770                 775                 780                 


Leu Ala Val Leu Phe Gly Ile Phe Leu Tyr Met Gly Val Thr Ser Leu 
785                 790                 795                 800 


Ser Gly Ile Gln Leu Phe Asp Arg Ile Leu Leu Leu Phe Lys Pro Pro 
                805                 810                 815     


Lys Tyr His Pro Asp Val Pro Tyr Val Lys Arg Val Lys Thr Trp Arg 
            820                 825                 830         


Met His Leu Phe Thr Gly Ile Gln Ile Ile Cys Leu Ala Val Leu Trp 
        835                 840                 845             


Val Val Lys Ser Thr Pro Ala Ser Leu Ala Leu Pro Phe Val Leu Ile 
    850                 855                 860                 


Leu Thr Val Pro Leu Arg Arg Val Leu Leu Pro Leu Ile Phe Arg Asn 
865                 870                 875                 880 


Val Glu Leu Gln Cys Leu Asp Ala Asp Asp Ala Lys Ala Thr Phe Asp 
                885                 890                 895     


Glu Glu Glu Gly Arg Asp Glu Tyr Asp Glu Val Ala Met Pro Val 
            900                 905                 910     


<210>  102
<211>  664
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Asp Ser Ser Thr Trp Ser Pro Lys Thr Thr Ala Val Thr Arg Pro 
1               5                   10                  15      


Val Glu Thr His Glu Leu Ile Arg Asn Ala Ala Asp Ile Ser Ile Ile 
            20                  25                  30          


Val Ile Tyr Phe Val Val Val Met Ala Val Gly Leu Trp Ala Met Phe 
        35                  40                  45              


Ser Thr Asn Arg Gly Thr Val Gly Gly Phe Phe Leu Ala Gly Arg Ser 
    50                  55                  60                  


Met Val Trp Trp Pro Ile Gly Ala Ser Leu Phe Ala Ser Asn Ile Gly 
65                  70                  75                  80  


Ser Gly His Phe Val Gly Leu Ala Gly Thr Gly Ala Ala Ser Gly Ile 
                85                  90                  95      


Ala Ile Gly Gly Phe Glu Trp Asn Ala Leu Val Leu Val Val Val Leu 
            100                 105                 110         


Gly Trp Leu Phe Val Pro Ile Tyr Ile Lys Ala Gly Val Val Thr Met 
        115                 120                 125             


Pro Glu Tyr Leu Arg Lys Arg Phe Gly Gly Gln Arg Ile Gln Val Tyr 
    130                 135                 140                 


Leu Ser Leu Leu Ser Leu Leu Leu Tyr Ile Phe Thr Lys Ile Ser Ala 
145                 150                 155                 160 


Asp Ile Phe Ser Gly Ala Ile Phe Ile Asn Leu Ala Leu Gly Leu Asn 
                165                 170                 175     


Leu Tyr Leu Ala Ile Phe Leu Leu Leu Ala Ile Thr Ala Leu Tyr Thr 
            180                 185                 190         


Ile Thr Gly Gly Leu Ala Ala Val Ile Tyr Thr Asp Thr Leu Gln Thr 
        195                 200                 205             


Val Ile Met Leu Val Gly Ser Leu Ile Leu Thr Gly Phe Ala Phe His 
    210                 215                 220                 


Glu Val Gly Gly Tyr Asp Ala Phe Met Glu Lys Tyr Met Lys Ala Ile 
225                 230                 235                 240 


Pro Thr Ile Val Ser Asp Gly Asn Thr Thr Phe Gln Glu Lys Cys Tyr 
                245                 250                 255     


Thr Pro Arg Ala Asp Ser Phe His Ile Phe Arg Asp Pro Leu Thr Gly 
            260                 265                 270         


Asp Leu Pro Trp Pro Gly Phe Ile Phe Gly Met Ser Ile Leu Thr Leu 
        275                 280                 285             


Trp Tyr Trp Cys Thr Asp Gln Val Ile Val Gln Arg Cys Leu Ser Ala 
    290                 295                 300                 


Lys Asn Met Ser His Val Lys Gly Gly Cys Ile Leu Cys Gly Tyr Leu 
305                 310                 315                 320 


Lys Leu Met Pro Met Phe Ile Met Val Met Pro Gly Met Ile Ser Arg 
                325                 330                 335     


Ile Leu Tyr Thr Glu Lys Ile Ala Cys Val Val Pro Ser Glu Cys Glu 
            340                 345                 350         


Lys Tyr Cys Gly Thr Lys Val Gly Cys Thr Asn Ile Ala Tyr Pro Thr 
        355                 360                 365             


Leu Val Val Glu Leu Met Pro Asn Gly Leu Arg Gly Leu Met Leu Ser 
    370                 375                 380                 


Val Met Leu Ala Ser Leu Met Ser Ser Leu Thr Ser Ile Phe Asn Ser 
385                 390                 395                 400 


Ala Ser Thr Leu Phe Thr Met Asp Ile Tyr Ala Lys Val Arg Lys Arg 
                405                 410                 415     


Ala Ser Glu Lys Glu Leu Met Ile Ala Gly Arg Leu Phe Ile Leu Val 
            420                 425                 430         


Leu Ile Gly Ile Ser Ile Ala Trp Val Pro Ile Val Gln Ser Ala Gln 
        435                 440                 445             


Ser Gly Gln Leu Phe Asp Tyr Ile Gln Ser Ile Thr Ser Tyr Leu Gly 
    450                 455                 460                 


Pro Pro Ile Ala Ala Val Phe Leu Leu Ala Ile Phe Trp Lys Arg Val 
465                 470                 475                 480 


Asn Glu Pro Gly Ala Phe Trp Gly Leu Ile Leu Gly Leu Leu Ile Gly 
                485                 490                 495     


Ile Ser Arg Met Ile Thr Glu Phe Ala Tyr Gly Thr Gly Ser Cys Met 
            500                 505                 510         


Glu Pro Ser Asn Cys Pro Thr Ile Ile Cys Gly Val His Tyr Leu Tyr 
        515                 520                 525             


Phe Ala Ile Ile Leu Phe Ala Ile Ser Phe Ile Thr Ile Val Val Ile 
    530                 535                 540                 


Ser Leu Leu Thr Lys Pro Ile Pro Asp Val His Leu Tyr Arg Leu Cys 
545                 550                 555                 560 


Trp Ser Leu Arg Asn Ser Lys Glu Glu Arg Ile Asp Leu Asp Ala Glu 
                565                 570                 575     


Glu Glu Asn Ile Gln Glu Gly Pro Lys Glu Thr Ile Glu Ile Glu Thr 
            580                 585                 590         


Gln Val Pro Glu Lys Lys Lys Gly Ile Phe Arg Arg Ala Tyr Asp Leu 
        595                 600                 605             


Phe Cys Gly Leu Glu Gln His Gly Ala Pro Lys Met Thr Glu Glu Glu 
    610                 615                 620                 


Glu Lys Ala Met Lys Met Lys Met Thr Asp Thr Ser Glu Lys Pro Leu 
625                 630                 635                 640 


Trp Arg Thr Val Leu Asn Val Asn Gly Ile Ile Leu Val Thr Val Ala 
                645                 650                 655     


Val Phe Cys His Ala Tyr Phe Ala 
            660                 


<210>  103
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Gln Val Gln Cys Gln Gln Ser Pro Val Leu Ala Gly Ser Ala Thr 
1               5                   10                  15      


Leu Val Ala Leu Gly Ala Leu Ala Leu Tyr Val Ala Lys Pro Ser Gly 
            20                  25                  30          


Tyr Gly Lys His Thr Glu Ser Leu Lys Pro Ala Ala Thr Arg Leu Pro 
        35                  40                  45              


Ala Arg Ala Ala Trp Phe Leu Gln Glu Leu Pro Ser Phe Ala Val Pro 
    50                  55                  60                  


Ala Gly Ile Leu Ala Arg Gln Pro Leu Ser Leu Phe Gly Pro Pro Gly 
65                  70                  75                  80  


Thr Val Leu Leu Gly Leu Phe Cys Leu His Tyr Phe His Arg Thr Phe 
                85                  90                  95      


Val Tyr Ser Leu Leu Asn Arg Gly Arg Pro Tyr Pro Ala Ile Leu Ile 
            100                 105                 110         


Leu Arg Gly Thr Ala Phe Cys Thr Gly Asn Gly Val Leu Gln Gly Tyr 
        115                 120                 125             


Tyr Leu Ile Tyr Cys Ala Glu Tyr Pro Asp Gly Trp Tyr Thr Asp Ile 
    130                 135                 140                 


Arg Phe Ser Leu Gly Val Phe Leu Phe Ile Leu Gly Met Gly Ile Asn 
145                 150                 155                 160 


Ile His Ser Asp Tyr Ile Leu Arg Gln Leu Arg Lys Pro Gly Glu Ile 
                165                 170                 175     


Ser Tyr Arg Ile Pro Gln Gly Gly Leu Phe Thr Tyr Val Ser Gly Ala 
            180                 185                 190         


Asn Phe Leu Gly Glu Ile Ile Glu Trp Ile Gly Tyr Ala Leu Ala Thr 
        195                 200                 205             


Trp Ser Leu Pro Ala Leu Ala Phe Ala Phe Phe Ser Leu Cys Phe Leu 
    210                 215                 220                 


Gly Leu Arg Ala Phe His His His Arg Phe Tyr Leu Lys Met Phe Glu 
225                 230                 235                 240 


Asp Tyr Pro Lys Ser Arg Lys Ala Leu Ile Pro Phe Ile Phe 
                245                 250                 


<210>  104
<211>  2273
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      


Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          


Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              


Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  


Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  


Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      


Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         


Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             


Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 


Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 


Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     


Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         


His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             


Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 


Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 


Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     


Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         


Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             


His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 


Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 


Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     


Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         


Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             


Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 


Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 


Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     


Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         


Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             


Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 


Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 


Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     


Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         


Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             


Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 


Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 


Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     


Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         


Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             


Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 


Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 


Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     


Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         


Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             


Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 


Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 


His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     


Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         


Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             


Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 


Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 


Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     


Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         


Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             


Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 


Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 


Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     


Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         


Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             


Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 


Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 


Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     


Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         


Asp Ile Glu Thr Ser Leu Asp Ala  Val Arg Gln Ser Leu  Gly Met Cys 
        995                 1000                 1005             


Pro Gln  His Asn Ile Leu Phe  His His Leu Thr Val  Ala Glu His 
    1010                 1015                 1020             


Met Leu  Phe Tyr Ala Gln Leu  Lys Gly Lys Ser Gln  Glu Glu Ala 
    1025                 1030                 1035             


Gln Leu  Glu Met Glu Ala Met  Leu Glu Asp Thr Gly  Leu His His 
    1040                 1045                 1050             


Lys Arg  Asn Glu Glu Ala Gln  Asp Leu Ser Gly Gly  Met Gln Arg 
    1055                 1060                 1065             


Lys Leu  Ser Val Ala Ile Ala  Phe Val Gly Asp Ala  Lys Val Val 
    1070                 1075                 1080             


Ile Leu  Asp Glu Pro Thr Ser  Gly Val Asp Pro Tyr  Ser Arg Arg 
    1085                 1090                 1095             


Ser Ile  Trp Asp Leu Leu Leu  Lys Tyr Arg Ser Gly  Arg Thr Ile 
    1100                 1105                 1110             


Ile Met  Ser Thr His His Met  Asp Glu Ala Asp Leu  Leu Gly Asp 
    1115                 1120                 1125             


Arg Ile  Ala Ile Ile Ala Gln  Gly Arg Leu Tyr Cys  Ser Gly Thr 
    1130                 1135                 1140             


Pro Leu  Phe Leu Lys Asn Cys  Phe Gly Thr Gly Leu  Tyr Leu Thr 
    1145                 1150                 1155             


Leu Val  Arg Lys Met Lys Asn  Ile Gln Ser Gln Arg  Lys Gly Ser 
    1160                 1165                 1170             


Glu Gly  Thr Cys Ser Cys Ser  Ser Lys Gly Phe Ser  Thr Thr Cys 
    1175                 1180                 1185             


Pro Ala  His Val Asp Asp Leu  Thr Pro Glu Gln Val  Leu Asp Gly 
    1190                 1195                 1200             


Asp Val  Asn Glu Leu Met Asp  Val Val Leu His His  Val Pro Glu 
    1205                 1210                 1215             


Ala Lys  Leu Val Glu Cys Ile  Gly Gln Glu Leu Ile  Phe Leu Leu 
    1220                 1225                 1230             


Pro Asn  Lys Asn Phe Lys His  Arg Ala Tyr Ala Ser  Leu Phe Arg 
    1235                 1240                 1245             


Glu Leu  Glu Glu Thr Leu Ala  Asp Leu Gly Leu Ser  Ser Phe Gly 
    1250                 1255                 1260             


Ile Ser  Asp Thr Pro Leu Glu  Glu Ile Phe Leu Lys  Val Thr Glu 
    1265                 1270                 1275             


Asp Ser  Asp Ser Gly Pro Leu  Phe Ala Gly Gly Ala  Gln Gln Lys 
    1280                 1285                 1290             


Arg Glu  Asn Val Asn Pro Arg  His Pro Cys Leu Gly  Pro Arg Glu 
    1295                 1300                 1305             


Lys Ala  Gly Gln Thr Pro Gln  Asp Ser Asn Val Cys  Ser Pro Gly 
    1310                 1315                 1320             


Ala Pro  Ala Ala His Pro Glu  Gly Gln Pro Pro Pro  Glu Pro Glu 
    1325                 1330                 1335             


Cys Pro  Gly Pro Gln Leu Asn  Thr Gly Thr Gln Leu  Val Leu Gln 
    1340                 1345                 1350             


His Val  Gln Ala Leu Leu Val  Lys Arg Phe Gln His  Thr Ile Arg 
    1355                 1360                 1365             


Ser His  Lys Asp Phe Leu Ala  Gln Ile Val Leu Pro  Ala Thr Phe 
    1370                 1375                 1380             


Val Phe  Leu Ala Leu Met Leu  Ser Ile Val Ile Pro  Pro Phe Gly 
    1385                 1390                 1395             


Glu Tyr  Pro Ala Leu Thr Leu  His Pro Trp Ile Tyr  Gly Gln Gln 
    1400                 1405                 1410             


Tyr Thr  Phe Phe Ser Met Asp  Glu Pro Gly Ser Glu  Gln Phe Thr 
    1415                 1420                 1425             


Val Leu  Ala Asp Val Leu Leu  Asn Lys Pro Gly Phe  Gly Asn Arg 
    1430                 1435                 1440             


Cys Leu  Lys Glu Gly Trp Leu  Pro Glu Tyr Pro Cys  Gly Asn Ser 
    1445                 1450                 1455             


Thr Pro  Trp Lys Thr Pro Ser  Val Ser Pro Asn Ile  Thr Gln Leu 
    1460                 1465                 1470             


Phe Gln  Lys Gln Lys Trp Thr  Gln Val Asn Pro Ser  Pro Ser Cys 
    1475                 1480                 1485             


Arg Cys  Ser Thr Arg Glu Lys  Leu Thr Met Leu Pro  Glu Cys Pro 
    1490                 1495                 1500             


Glu Gly  Ala Gly Gly Leu Pro  Pro Pro Gln Arg Thr  Gln Arg Ser 
    1505                 1510                 1515             


Thr Glu  Ile Leu Gln Asp Leu  Thr Asp Arg Asn Ile  Ser Asp Phe 
    1520                 1525                 1530             


Leu Val  Lys Thr Tyr Pro Ala  Leu Ile Arg Ser Ser  Leu Lys Ser 
    1535                 1540                 1545             


Lys Phe  Trp Val Asn Glu Gln  Arg Tyr Gly Gly Ile  Ser Ile Gly 
    1550                 1555                 1560             


Gly Lys  Leu Pro Val Val Pro  Ile Thr Gly Glu Ala  Leu Val Gly 
    1565                 1570                 1575             


Phe Leu  Ser Asp Leu Gly Arg  Ile Met Asn Val Ser  Gly Gly Pro 
    1580                 1585                 1590             


Ile Thr  Arg Glu Ala Ser Lys  Glu Ile Pro Asp Phe  Leu Lys His 
    1595                 1600                 1605             


Leu Glu  Thr Glu Asp Asn Ile  Lys Val Trp Phe Asn  Asn Lys Gly 
    1610                 1615                 1620             


Trp His  Ala Leu Val Ser Phe  Leu Asn Val Ala His  Asn Ala Ile 
    1625                 1630                 1635             


Leu Arg  Ala Ser Leu Pro Lys  Asp Arg Ser Pro Glu  Glu Tyr Gly 
    1640                 1645                 1650             


Ile Thr  Val Ile Ser Gln Pro  Leu Asn Leu Thr Lys  Glu Gln Leu 
    1655                 1660                 1665             


Ser Glu  Ile Thr Val Leu Thr  Thr Ser Val Asp Ala  Val Val Ala 
    1670                 1675                 1680             


Ile Cys  Val Ile Phe Ser Met  Ser Phe Val Pro Ala  Ser Phe Val 
    1685                 1690                 1695             


Leu Tyr  Leu Ile Gln Glu Arg  Val Asn Lys Ser Lys  His Leu Gln 
    1700                 1705                 1710             


Phe Ile  Ser Gly Val Ser Pro  Thr Thr Tyr Trp Val  Thr Asn Phe 
    1715                 1720                 1725             


Leu Trp  Asp Ile Met Asn Tyr  Ser Val Ser Ala Gly  Leu Val Val 
    1730                 1735                 1740             


Gly Ile  Phe Ile Gly Phe Gln  Lys Lys Ala Tyr Thr  Ser Pro Glu 
    1745                 1750                 1755             


Asn Leu  Pro Ala Leu Val Ala  Leu Leu Leu Leu Tyr  Gly Trp Ala 
    1760                 1765                 1770             


Val Ile  Pro Met Met Tyr Pro  Ala Ser Phe Leu Phe  Asp Val Pro 
    1775                 1780                 1785             


Ser Thr  Ala Tyr Val Ala Leu  Ser Cys Ala Asn Leu  Phe Ile Gly 
    1790                 1795                 1800             


Ile Asn  Ser Ser Ala Ile Thr  Phe Ile Leu Glu Leu  Phe Glu Asn 
    1805                 1810                 1815             


Asn Arg  Thr Leu Leu Arg Phe  Asn Ala Val Leu Arg  Lys Leu Leu 
    1820                 1825                 1830             


Ile Val  Phe Pro His Phe Cys  Leu Gly Arg Gly Leu  Ile Asp Leu 
    1835                 1840                 1845             


Ala Leu  Ser Gln Ala Val Thr  Asp Val Tyr Ala Arg  Phe Gly Glu 
    1850                 1855                 1860             


Glu His  Ser Ala Asn Pro Phe  His Trp Asp Leu Ile  Gly Lys Asn 
    1865                 1870                 1875             


Leu Phe  Ala Met Val Val Glu  Gly Val Val Tyr Phe  Leu Leu Thr 
    1880                 1885                 1890             


Leu Leu  Val Gln Arg His Phe  Phe Leu Ser Gln Trp  Ile Ala Glu 
    1895                 1900                 1905             


Pro Thr  Lys Glu Pro Ile Val  Asp Glu Asp Asp Asp  Val Ala Glu 
    1910                 1915                 1920             


Glu Arg  Gln Arg Ile Ile Thr  Gly Gly Asn Lys Thr  Asp Ile Leu 
    1925                 1930                 1935             


Arg Leu  His Glu Leu Thr Lys  Ile Tyr Pro Gly Thr  Ser Ser Pro 
    1940                 1945                 1950             


Ala Val  Asp Arg Leu Cys Val  Gly Val Arg Pro Gly  Glu Cys Phe 
    1955                 1960                 1965             


Gly Leu  Leu Gly Val Asn Gly  Ala Gly Lys Thr Thr  Thr Phe Lys 
    1970                 1975                 1980             


Met Leu  Thr Gly Asp Thr Thr  Val Thr Ser Gly Asp  Ala Thr Val 
    1985                 1990                 1995             


Ala Gly  Lys Ser Ile Leu Thr  Asn Ile Ser Glu Val  His Gln Asn 
    2000                 2005                 2010             


Met Gly  Tyr Cys Pro Gln Phe  Asp Ala Ile Asp Glu  Leu Leu Thr 
    2015                 2020                 2025             


Gly Arg  Glu His Leu Tyr Leu  Tyr Ala Arg Leu Arg  Gly Val Pro 
    2030                 2035                 2040             


Ala Glu  Glu Ile Glu Lys Val  Ala Asn Trp Ser Ile  Lys Ser Leu 
    2045                 2050                 2055             


Gly Leu  Thr Val Tyr Ala Asp  Cys Leu Ala Gly Thr  Tyr Ser Gly 
    2060                 2065                 2070             


Gly Asn  Lys Arg Lys Leu Ser  Thr Ala Ile Ala Leu  Ile Gly Cys 
    2075                 2080                 2085             


Pro Pro  Leu Val Leu Leu Asp  Glu Pro Thr Thr Gly  Met Asp Pro 
    2090                 2095                 2100             


Gln Ala  Arg Arg Met Leu Trp  Asn Val Ile Val Ser  Ile Ile Arg 
    2105                 2110                 2115             


Glu Gly  Arg Ala Val Val Leu  Thr Ser His Ser Met  Glu Glu Cys 
    2120                 2125                 2130             


Glu Ala  Leu Cys Thr Arg Leu  Ala Ile Met Val Lys  Gly Ala Phe 
    2135                 2140                 2145             


Arg Cys  Met Gly Thr Ile Gln  His Leu Lys Ser Lys  Phe Gly Asp 
    2150                 2155                 2160             


Gly Tyr  Ile Val Thr Met Lys  Ile Lys Ser Pro Lys  Asp Asp Leu 
    2165                 2170                 2175             


Leu Pro  Asp Leu Asn Pro Val  Glu Gln Phe Phe Gln  Gly Asn Phe 
    2180                 2185                 2190             


Pro Gly  Ser Val Gln Arg Glu  Arg His Tyr Asn Met  Leu Gln Phe 
    2195                 2200                 2205             


Gln Val  Ser Ser Ser Ser Leu  Ala Arg Ile Phe Gln  Leu Leu Leu 
    2210                 2215                 2220             


Ser His  Lys Asp Ser Leu Leu  Ile Glu Glu Tyr Ser  Val Thr Gln 
    2225                 2230                 2235             


Thr Thr  Leu Asp Gln Val Phe  Val Asn Phe Ala Lys  Gln Gln Thr 
    2240                 2245                 2250             


Glu Ser  His Asp Leu Pro Leu  His Pro Arg Ala Ala  Gly Ala Ser 
    2255                 2260                 2265             


Arg Gln  Ala Gln Asp 
    2270             


<210>  105
<211>  583
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Pro Leu Arg Lys Met Lys Ile Pro Phe Leu Leu Leu Phe Phe Leu 
1               5                   10                  15      


Trp Glu Ala Glu Ser His Ala Ala Ser Arg Pro Asn Ile Ile Leu Val 
            20                  25                  30          


Met Ala Asp Asp Leu Gly Ile Gly Asp Pro Gly Cys Tyr Gly Asn Lys 
        35                  40                  45              


Thr Ile Arg Thr Pro Asn Ile Asp Arg Leu Ala Ser Gly Gly Val Lys 
    50                  55                  60                  


Leu Thr Gln His Leu Ala Ala Ser Pro Leu Cys Thr Pro Ser Arg Ala 
65                  70                  75                  80  


Ala Phe Met Thr Gly Arg Tyr Pro Val Arg Ser Gly Met Ala Ser Trp 
                85                  90                  95      


Ser Arg Thr Gly Val Phe Leu Phe Thr Ala Ser Ser Gly Gly Leu Pro 
            100                 105                 110         


Thr Asp Glu Ile Thr Phe Ala Lys Leu Leu Lys Asp Gln Gly Tyr Ser 
        115                 120                 125             


Thr Ala Leu Ile Gly Lys Trp His Leu Gly Met Ser Cys His Ser Lys 
    130                 135                 140                 


Thr Asp Phe Cys His His Pro Leu His His Gly Phe Asn Tyr Phe Tyr 
145                 150                 155                 160 


Gly Ile Ser Leu Thr Asn Leu Arg Asp Cys Lys Pro Gly Glu Gly Ser 
                165                 170                 175     


Val Phe Thr Thr Gly Phe Lys Arg Leu Val Phe Leu Pro Leu Gln Ile 
            180                 185                 190         


Val Gly Val Thr Leu Leu Thr Leu Ala Ala Leu Asn Cys Leu Gly Leu 
        195                 200                 205             


Leu His Val Pro Leu Gly Val Phe Phe Ser Leu Leu Phe Leu Ala Ala 
    210                 215                 220                 


Leu Ile Leu Thr Leu Phe Leu Gly Phe Leu His Tyr Phe Arg Pro Leu 
225                 230                 235                 240 


Asn Cys Phe Met Met Arg Asn Tyr Glu Ile Ile Gln Gln Pro Met Ser 
                245                 250                 255     


Tyr Asp Asn Leu Thr Gln Arg Leu Thr Val Glu Ala Ala Gln Phe Ile 
            260                 265                 270         


Gln Arg Asn Thr Glu Thr Pro Phe Leu Leu Val Leu Ser Tyr Leu His 
        275                 280                 285             


Val His Thr Ala Leu Phe Ser Ser Lys Asp Phe Ala Gly Lys Ser Gln 
    290                 295                 300                 


His Gly Val Tyr Gly Asp Ala Val Glu Glu Met Asp Trp Ser Val Gly 
305                 310                 315                 320 


Gln Ile Leu Asn Leu Leu Asp Glu Leu Arg Leu Ala Asn Asp Thr Leu 
                325                 330                 335     


Ile Tyr Phe Thr Ser Asp Gln Gly Ala His Val Glu Glu Val Ser Ser 
            340                 345                 350         


Lys Gly Glu Ile His Gly Gly Ser Asn Gly Ile Tyr Lys Gly Gly Lys 
        355                 360                 365             


Ala Asn Asn Trp Glu Gly Gly Ile Arg Val Pro Gly Ile Leu Arg Trp 
    370                 375                 380                 


Pro Arg Val Ile Gln Ala Gly Gln Lys Ile Asp Glu Pro Thr Ser Asn 
385                 390                 395                 400 


Met Asp Ile Phe Pro Thr Val Ala Lys Leu Ala Gly Ala Pro Leu Pro 
                405                 410                 415     


Glu Asp Arg Ile Ile Asp Gly Arg Asp Leu Met Pro Leu Leu Glu Gly 
            420                 425                 430         


Lys Ser Gln Arg Ser Asp His Glu Phe Leu Phe His Tyr Cys Asn Ala 
        435                 440                 445             


Tyr Leu Asn Ala Val Arg Trp His Pro Gln Asn Ser Thr Ser Ile Trp 
    450                 455                 460                 


Lys Ala Phe Phe Phe Thr Pro Asn Phe Asn Pro Val Gly Ser Asn Gly 
465                 470                 475                 480 


Cys Phe Ala Thr His Val Cys Phe Cys Phe Gly Ser Tyr Val Thr His 
                485                 490                 495     


His Asp Pro Pro Leu Leu Phe Asp Ile Ser Lys Asp Pro Arg Glu Arg 
            500                 505                 510         


Asn Pro Leu Thr Pro Ala Ser Glu Pro Arg Phe Tyr Glu Ile Leu Lys 
        515                 520                 525             


Val Met Gln Glu Ala Ala Asp Arg His Thr Gln Thr Leu Pro Glu Val 
    530                 535                 540                 


Pro Asp Gln Phe Ser Trp Asn Asn Phe Leu Trp Lys Pro Trp Leu Gln 
545                 550                 555                 560 


Leu Cys Cys Pro Ser Thr Gly Leu Ser Cys Gln Cys Asp Arg Glu Lys 
                565                 570                 575     


Gln Asp Lys Arg Leu Ser Arg 
            580             


<210>  106
<211>  1581
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Pro Leu Ala Phe Cys Gly Ser Glu Asn His Ser Ala Ala Tyr Arg 
1               5                   10                  15      


Val Asp Gln Gly Val Leu Asn Asn Gly Cys Phe Val Asp Ala Leu Asn 
            20                  25                  30          


Val Val Pro His Val Phe Leu Leu Phe Ile Thr Phe Pro Ile Leu Phe 
        35                  40                  45              


Ile Gly Trp Gly Ser Gln Ser Ser Lys Val His Ile His His Ser Thr 
    50                  55                  60                  


Trp Leu His Phe Pro Gly His Asn Leu Arg Trp Ile Leu Thr Phe Met 
65                  70                  75                  80  


Leu Leu Phe Val Leu Val Cys Glu Ile Ala Glu Gly Ile Leu Ser Asp 
                85                  90                  95      


Gly Val Thr Glu Ser His His Leu His Leu Tyr Met Pro Ala Gly Met 
            100                 105                 110         


Ala Phe Met Ala Ala Val Thr Ser Val Val Tyr Tyr His Asn Ile Glu 
        115                 120                 125             


Thr Ser Asn Phe Pro Lys Leu Leu Ile Ala Leu Leu Val Tyr Trp Thr 
    130                 135                 140                 


Leu Ala Phe Ile Thr Lys Thr Ile Lys Phe Val Lys Phe Leu Asp His 
145                 150                 155                 160 


Ala Ile Gly Phe Ser Gln Leu Arg Phe Cys Leu Thr Gly Leu Leu Val 
                165                 170                 175     


Ile Leu Tyr Gly Met Leu Leu Leu Val Glu Val Asn Val Ile Arg Val 
            180                 185                 190         


Arg Arg Tyr Ile Phe Phe Lys Thr Pro Arg Glu Val Lys Pro Pro Glu 
        195                 200                 205             


Asp Leu Gln Asp Leu Gly Val Arg Phe Leu Gln Pro Phe Val Asn Leu 
    210                 215                 220                 


Leu Ser Lys Gly Thr Tyr Trp Trp Met Asn Ala Phe Ile Lys Thr Ala 
225                 230                 235                 240 


His Lys Lys Pro Ile Asp Leu Arg Ala Ile Gly Lys Leu Pro Ile Ala 
                245                 250                 255     


Met Arg Ala Leu Thr Asn Tyr Gln Arg Leu Cys Glu Ala Phe Asp Ala 
            260                 265                 270         


Gln Val Arg Lys Asp Ile Gln Gly Thr Gln Gly Ala Arg Ala Ile Trp 
        275                 280                 285             


Gln Ala Leu Ser His Ala Phe Gly Arg Arg Leu Val Leu Ser Ser Thr 
    290                 295                 300                 


Phe Arg Ile Leu Ala Asp Leu Leu Gly Phe Ala Gly Pro Leu Cys Ile 
305                 310                 315                 320 


Phe Gly Ile Val Asp His Leu Gly Lys Glu Asn Asp Val Phe Gln Pro 
                325                 330                 335     


Lys Thr Gln Phe Leu Gly Val Tyr Phe Val Ser Ser Gln Glu Phe Leu 
            340                 345                 350         


Ala Asn Ala Tyr Val Leu Ala Val Leu Leu Phe Leu Ala Leu Leu Leu 
        355                 360                 365             


Gln Arg Thr Phe Leu Gln Ala Ser Tyr Tyr Val Ala Ile Glu Thr Gly 
    370                 375                 380                 


Ile Asn Leu Arg Gly Ala Ile Gln Thr Lys Ile Tyr Asn Lys Ile Met 
385                 390                 395                 400 


His Leu Ser Thr Ser Asn Leu Ser Met Gly Glu Met Thr Ala Gly Gln 
                405                 410                 415     


Ile Cys Asn Leu Val Ala Ile Asp Thr Asn Gln Leu Met Trp Phe Phe 
            420                 425                 430         


Phe Leu Cys Pro Asn Leu Trp Ala Met Pro Val Gln Ile Ile Val Gly 
        435                 440                 445             


Val Ile Leu Leu Tyr Tyr Ile Leu Gly Val Ser Ala Leu Ile Gly Ala 
    450                 455                 460                 


Ala Val Ile Ile Leu Leu Ala Pro Val Gln Tyr Phe Val Ala Thr Lys 
465                 470                 475                 480 


Leu Ser Gln Ala Gln Arg Ser Thr Leu Glu Tyr Ser Asn Glu Arg Leu 
                485                 490                 495     


Lys Gln Thr Asn Glu Met Leu Arg Gly Ile Lys Leu Leu Lys Leu Tyr 
            500                 505                 510         


Ala Trp Glu Asn Ile Phe Arg Thr Arg Val Glu Thr Thr Arg Arg Lys 
        515                 520                 525             


Glu Met Thr Ser Leu Arg Ala Phe Ala Ile Tyr Thr Ser Ile Ser Ile 
    530                 535                 540                 


Phe Met Asn Thr Ala Ile Pro Ile Ala Ala Val Leu Ile Thr Phe Val 
545                 550                 555                 560 


Gly His Val Ser Phe Phe Lys Glu Ala Asp Phe Ser Pro Ser Val Ala 
                565                 570                 575     


Phe Ala Ser Leu Ser Leu Phe His Ile Leu Val Thr Pro Leu Phe Leu 
            580                 585                 590         


Leu Ser Ser Val Val Arg Ser Thr Val Lys Ala Leu Val Ser Val Gln 
        595                 600                 605             


Lys Leu Ser Glu Phe Leu Ser Ser Ala Glu Ile Arg Glu Glu Gln Cys 
    610                 615                 620                 


Ala Pro His Glu Pro Thr Pro Gln Gly Pro Ala Ser Lys Tyr Gln Ala 
625                 630                 635                 640 


Val Pro Leu Arg Val Val Asn Arg Lys Arg Pro Ala Arg Glu Asp Cys 
                645                 650                 655     


Arg Gly Leu Thr Gly Pro Leu Gln Ser Leu Val Pro Ser Ala Asp Gly 
            660                 665                 670         


Asp Ala Asp Asn Cys Cys Val Gln Ile Met Gly Gly Tyr Phe Thr Trp 
        675                 680                 685             


Thr Pro Asp Gly Ile Pro Thr Leu Ser Asn Ile Thr Ile Arg Ile Pro 
    690                 695                 700                 


Arg Gly Gln Leu Thr Met Ile Val Gly Gln Val Gly Cys Gly Lys Ser 
705                 710                 715                 720 


Ser Leu Leu Leu Ala Ala Leu Gly Glu Met Gln Lys Val Ser Gly Ala 
                725                 730                 735     


Val Phe Trp Ser Ser Leu Pro Asp Ser Glu Ile Gly Glu Asp Pro Ser 
            740                 745                 750         


Pro Glu Arg Glu Thr Ala Thr Asp Leu Asp Ile Arg Lys Arg Gly Pro 
        755                 760                 765             


Val Ala Tyr Ala Ser Gln Lys Pro Trp Leu Leu Asn Ala Thr Val Glu 
    770                 775                 780                 


Glu Asn Ile Ile Phe Glu Ser Pro Phe Asn Lys Gln Arg Tyr Lys Met 
785                 790                 795                 800 


Val Ile Glu Ala Cys Ser Leu Gln Pro Asp Ile Asp Ile Leu Pro His 
                805                 810                 815     


Gly Asp Gln Thr Gln Ile Gly Glu Arg Gly Ile Asn Leu Ser Gly Gly 
            820                 825                 830         


Gln Arg Gln Arg Ile Ser Val Ala Arg Ala Leu Tyr Gln His Ala Asn 
        835                 840                 845             


Val Val Phe Leu Asp Asp Pro Phe Ser Ala Leu Asp Ile His Leu Ser 
    850                 855                 860                 


Asp His Leu Met Gln Ala Gly Ile Leu Glu Leu Leu Arg Asp Asp Lys 
865                 870                 875                 880 


Arg Thr Val Val Leu Val Thr His Lys Leu Gln Tyr Leu Pro His Ala 
                885                 890                 895     


Asp Trp Ile Ile Ala Met Lys Asp Gly Thr Ile Gln Arg Glu Gly Thr 
            900                 905                 910         


Leu Lys Asp Phe Gln Arg Ser Glu Cys Gln Leu Phe Glu His Trp Lys 
        915                 920                 925             


Thr Leu Met Asn Arg Gln Asp Gln Glu Leu Glu Lys Glu Thr Val Thr 
    930                 935                 940                 


Glu Arg Lys Ala Thr Glu Pro Pro Gln Gly Leu Ser Arg Ala Met Ser 
945                 950                 955                 960 


Ser Arg Asp Gly Leu Leu Gln Asp Glu Glu Glu Glu Glu Glu Glu Ala 
                965                 970                 975     


Ala Glu Ser Glu Glu Asp Asp Asn Leu Ser Ser Met Leu His Gln Arg 
            980                 985                 990         


Ala Glu Ile Pro Trp Arg Ala Cys  Ala Lys Tyr Leu Ser  Ser Ala Gly 
        995                 1000                 1005             


Ile Leu  Leu Leu Ser Leu Leu  Val Phe Ser Gln Leu  Leu Lys His 
    1010                 1015                 1020             


Met Val  Leu Val Ala Ile Asp  Tyr Trp Leu Ala Lys  Trp Thr Asp 
    1025                 1030                 1035             


Ser Ala  Leu Thr Leu Thr Pro  Ala Ala Arg Asn Cys  Ser Leu Ser 
    1040                 1045                 1050             


Gln Glu  Cys Thr Leu Asp Gln  Thr Val Tyr Ala Met  Val Phe Thr 
    1055                 1060                 1065             


Val Leu  Cys Ser Leu Gly Ile  Val Leu Cys Leu Val  Thr Ser Val 
    1070                 1075                 1080             


Thr Val  Glu Trp Thr Gly Leu  Lys Val Ala Lys Arg  Leu His Arg 
    1085                 1090                 1095             


Ser Leu  Leu Asn Arg Ile Ile  Leu Ala Pro Met Arg  Phe Phe Glu 
    1100                 1105                 1110             


Thr Thr  Pro Leu Gly Ser Ile  Leu Asn Arg Phe Ser  Ser Asp Cys 
    1115                 1120                 1125             


Asn Thr  Ile Asp Gln His Ile  Pro Ser Thr Leu Glu  Cys Leu Ser 
    1130                 1135                 1140             


Arg Ser  Thr Leu Leu Cys Val  Ser Ala Leu Ala Val  Ile Ser Tyr 
    1145                 1150                 1155             


Val Thr  Pro Val Phe Leu Val  Ala Leu Leu Pro Leu  Ala Ile Val 
    1160                 1165                 1170             


Cys Tyr  Phe Ile Gln Lys Tyr  Phe Arg Val Ala Ser  Arg Asp Leu 
    1175                 1180                 1185             


Gln Gln  Leu Asp Asp Thr Thr  Gln Leu Pro Leu Leu  Ser His Phe 
    1190                 1195                 1200             


Ala Glu  Thr Val Glu Gly Leu  Thr Thr Ile Arg Ala  Phe Arg Tyr 
    1205                 1210                 1215             


Glu Ala  Arg Phe Gln Gln Lys  Leu Leu Glu Tyr Thr  Asp Ser Asn 
    1220                 1225                 1230             


Asn Ile  Ala Ser Leu Phe Leu  Thr Ala Ala Asn Arg  Trp Leu Glu 
    1235                 1240                 1245             


Val Arg  Met Glu Tyr Ile Gly  Ala Cys Val Val Leu  Ile Ala Ala 
    1250                 1255                 1260             


Val Thr  Ser Ile Ser Asn Ser  Leu His Arg Glu Leu  Ser Ala Gly 
    1265                 1270                 1275             


Leu Val  Gly Leu Gly Leu Thr  Tyr Ala Leu Met Val  Ser Asn Tyr 
    1280                 1285                 1290             


Leu Asn  Trp Met Val Arg Asn  Leu Ala Asp Met Glu  Leu Gln Leu 
    1295                 1300                 1305             


Gly Ala  Val Lys Arg Ile His  Gly Leu Leu Lys Thr  Glu Ala Glu 
    1310                 1315                 1320             


Ser Tyr  Glu Gly Leu Leu Ala  Pro Ser Leu Ile Pro  Lys Asn Trp 
    1325                 1330                 1335             


Pro Asp  Gln Gly Lys Ile Gln  Ile Gln Asn Leu Ser  Val Arg Tyr 
    1340                 1345                 1350             


Asp Ser  Ser Leu Lys Pro Val  Leu Lys His Val Asn  Ala Leu Ile 
    1355                 1360                 1365             


Ala Pro  Gly Gln Lys Ile Gly  Ile Cys Gly Arg Thr  Gly Ser Gly 
    1370                 1375                 1380             


Lys Ser  Ser Phe Ser Leu Ala  Phe Phe Arg Met Val  Asp Thr Phe 
    1385                 1390                 1395             


Glu Gly  His Ile Ile Ile Asp  Gly Ile Asp Ile Ala  Lys Leu Pro 
    1400                 1405                 1410             


Leu His  Thr Leu Arg Ser Arg  Leu Ser Ile Ile Leu  Gln Asp Pro 
    1415                 1420                 1425             


Val Leu  Phe Ser Gly Thr Ile  Arg Phe Asn Leu Asp  Pro Glu Arg 
    1430                 1435                 1440             


Lys Cys  Ser Asp Ser Thr Leu  Trp Glu Ala Leu Glu  Ile Ala Gln 
    1445                 1450                 1455             


Leu Lys  Leu Val Val Lys Ala  Leu Pro Gly Gly Leu  Asp Ala Ile 
    1460                 1465                 1470             


Ile Thr  Glu Gly Gly Glu Asn  Phe Ser Gln Gly Gln  Arg Gln Leu 
    1475                 1480                 1485             


Phe Cys  Leu Ala Arg Ala Phe  Val Arg Lys Thr Ser  Ile Phe Ile 
    1490                 1495                 1500             


Met Asp  Glu Ala Thr Ala Ser  Ile Asp Met Ala Thr  Glu Asn Ile 
    1505                 1510                 1515             


Leu Gln  Lys Val Val Met Thr  Ala Phe Ala Asp Arg  Thr Val Val 
    1520                 1525                 1530             


Thr Ile  Ala His Arg Val His  Thr Ile Leu Ser Ala  Asp Leu Val 
    1535                 1540                 1545             


Ile Val  Leu Lys Arg Gly Ala  Ile Leu Glu Phe Asp  Lys Pro Glu 
    1550                 1555                 1560             


Lys Leu  Leu Ser Arg Lys Asp  Ser Val Phe Ala Ser  Phe Val Arg 
    1565                 1570                 1575             


Ala Asp  Lys 
    1580     


<210>  107
<211>  683
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Ala Leu Phe Val Arg Leu Leu Ala Leu Ala Leu Ala Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ala Ala Thr Leu Ala Gly Pro Ala Lys Ser Pro Tyr Gln Leu 
            20                  25                  30          


Val Leu Gln His Ser Arg Leu Arg Gly Arg Gln His Gly Pro Asn Val 
        35                  40                  45              


Cys Ala Val Gln Lys Val Ile Gly Thr Asn Arg Lys Tyr Phe Thr Asn 
    50                  55                  60                  


Cys Lys Gln Trp Tyr Gln Arg Lys Ile Cys Gly Lys Ser Thr Val Ile 
65                  70                  75                  80  


Ser Tyr Glu Cys Cys Pro Gly Tyr Glu Lys Val Pro Gly Glu Lys Gly 
                85                  90                  95      


Cys Pro Ala Ala Leu Pro Leu Ser Asn Leu Tyr Glu Thr Leu Gly Val 
            100                 105                 110         


Val Gly Ser Thr Thr Thr Gln Leu Tyr Thr Asp Arg Thr Glu Lys Leu 
        115                 120                 125             


Arg Pro Glu Met Glu Gly Pro Gly Ser Phe Thr Ile Phe Ala Pro Ser 
    130                 135                 140                 


Asn Glu Ala Trp Ala Ser Leu Pro Ala Glu Val Leu Asp Ser Leu Val 
145                 150                 155                 160 


Ser Asn Val Asn Ile Glu Leu Leu Asn Ala Leu Arg Tyr His Met Val 
                165                 170                 175     


Gly Arg Arg Val Leu Thr Asp Glu Leu Lys His Gly Met Thr Leu Thr 
            180                 185                 190         


Ser Met Tyr Gln Asn Ser Asn Ile Gln Ile His His Tyr Pro Asn Gly 
        195                 200                 205             


Ile Val Thr Val Asn Cys Ala Arg Leu Leu Lys Ala Asp His His Ala 
    210                 215                 220                 


Thr Asn Gly Val Val His Leu Ile Asp Lys Val Ile Ser Thr Ile Thr 
225                 230                 235                 240 


Asn Asn Ile Gln Gln Ile Ile Glu Ile Glu Asp Thr Phe Glu Thr Leu 
                245                 250                 255     


Arg Ala Ala Val Ala Ala Ser Gly Leu Asn Thr Met Leu Glu Gly Asn 
            260                 265                 270         


Gly Gln Tyr Thr Leu Leu Ala Pro Thr Asn Glu Ala Phe Glu Lys Ile 
        275                 280                 285             


Pro Ser Glu Thr Leu Asn Arg Ile Leu Gly Asp Pro Glu Ala Leu Arg 
    290                 295                 300                 


Asp Leu Leu Asn Asn His Ile Leu Lys Ser Ala Met Cys Ala Glu Ala 
305                 310                 315                 320 


Ile Val Ala Gly Leu Ser Val Glu Thr Leu Glu Gly Thr Thr Leu Glu 
                325                 330                 335     


Val Gly Cys Ser Gly Asp Met Leu Thr Ile Asn Gly Lys Ala Ile Ile 
            340                 345                 350         


Ser Asn Lys Asp Ile Leu Ala Thr Asn Gly Val Ile His Tyr Ile Asp 
        355                 360                 365             


Glu Leu Leu Ile Pro Asp Ser Ala Lys Thr Leu Phe Glu Leu Ala Ala 
    370                 375                 380                 


Glu Ser Asp Val Ser Thr Ala Ile Asp Leu Phe Arg Gln Ala Gly Leu 
385                 390                 395                 400 


Gly Asn His Leu Ser Gly Ser Glu Arg Leu Thr Leu Leu Ala Pro Leu 
                405                 410                 415     


Asn Ser Val Phe Lys Asp Gly Thr Pro Pro Ile Asp Ala His Thr Arg 
            420                 425                 430         


Asn Leu Leu Arg Asn His Ile Ile Lys Asp Gln Leu Ala Ser Lys Tyr 
        435                 440                 445             


Leu Tyr His Gly Gln Thr Leu Glu Thr Leu Gly Gly Lys Lys Leu Arg 
    450                 455                 460                 


Val Phe Val Tyr Arg Asn Ser Leu Cys Ile Glu Asn Ser Cys Ile Ala 
465                 470                 475                 480 


Ala His Asp Lys Arg Gly Arg Tyr Gly Thr Leu Phe Thr Met Asp Arg 
                485                 490                 495     


Val Leu Thr Pro Pro Met Gly Thr Val Met Asp Val Leu Lys Gly Asp 
            500                 505                 510         


Asn Arg Phe Ser Met Leu Val Ala Ala Ile Gln Ser Ala Gly Leu Thr 
        515                 520                 525             


Glu Thr Leu Asn Arg Glu Gly Val Tyr Thr Val Phe Ala Pro Thr Asn 
    530                 535                 540                 


Glu Ala Phe Arg Ala Leu Pro Pro Arg Glu Arg Ser Arg Leu Leu Gly 
545                 550                 555                 560 


Asp Ala Lys Glu Leu Ala Asn Ile Leu Lys Tyr His Ile Gly Asp Glu 
                565                 570                 575     


Ile Leu Val Ser Gly Gly Ile Gly Ala Leu Val Arg Leu Lys Ser Leu 
            580                 585                 590         


Gln Gly Asp Lys Leu Glu Val Ser Leu Lys Asn Asn Val Val Ser Val 
        595                 600                 605             


Asn Lys Glu Pro Val Ala Glu Pro Asp Ile Met Ala Thr Asn Gly Val 
    610                 615                 620                 


Val His Val Ile Thr Asn Val Leu Gln Pro Pro Ala Asn Arg Pro Gln 
625                 630                 635                 640 


Glu Arg Gly Asp Glu Leu Ala Asp Ser Ala Leu Glu Ile Phe Lys Gln 
                645                 650                 655     


Ala Ser Ala Phe Ser Arg Ala Ser Gln Arg Ser Val Arg Leu Ala Pro 
            660                 665                 670         


Val Tyr Gln Lys Leu Leu Glu Arg Met Lys His 
        675                 680             


<210>  108
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Leu Gly Val Leu Val Leu Gly Ala Leu Ala Leu Ala Gly Leu Gly 
1               5                   10                  15      


Phe Pro Ala Pro Ala Glu Pro Gln Pro Gly Gly Ser Gln Cys Val Glu 
            20                  25                  30          


His Asp Cys Phe Ala Leu Tyr Pro Gly Pro Ala Thr Phe Leu Asn Ala 
        35                  40                  45              


Ser Gln Ile Cys Asp Gly Leu Arg Gly His Leu Met Thr Val Arg Ser 
    50                  55                  60                  


Ser Val Ala Ala Asp Val Ile Ser Leu Leu Leu Asn Gly Asp Gly Gly 
65                  70                  75                  80  


Val Gly Arg Arg Arg Leu Trp Ile Gly Leu Gln Leu Pro Pro Gly Cys 
                85                  90                  95      


Gly Asp Pro Lys Arg Leu Gly Pro Leu Arg Gly Phe Gln Trp Val Thr 
            100                 105                 110         


Gly Asp Asn Asn Thr Ser Tyr Ser Arg Trp Ala Arg Leu Asp Leu Asn 
        115                 120                 125             


Gly Ala Pro Leu Cys Gly Pro Leu Cys Val Ala Val Ser Ala Ala Glu 
    130                 135                 140                 


Ala Thr Val Pro Ser Glu Pro Ile Trp Glu Glu Gln Gln Cys Glu Val 
145                 150                 155                 160 


Lys Ala Asp Gly Phe Leu Cys Glu Phe His Phe Pro Ala Thr Cys Arg 
                165                 170                 175     


Pro Leu Ala Val Glu Pro Gly Ala Ala Ala Ala Ala Val Ser Ile Thr 
            180                 185                 190         


Tyr Gly Thr Pro Phe Ala Ala Arg Gly Ala Asp Phe Gln Ala Leu Pro 
        195                 200                 205             


Val Gly Ser Ser Ala Ala Val Ala Pro Leu Gly Leu Gln Leu Met Cys 
    210                 215                 220                 


Thr Ala Pro Pro Gly Ala Val Gln Gly His Trp Ala Arg Glu Ala Pro 
225                 230                 235                 240 


Gly Ala Trp Asp Cys Ser Val Glu Asn Gly Gly Cys Glu His Ala Cys 
                245                 250                 255     


Asn Ala Ile Pro Gly Ala Pro Arg Cys Gln Cys Pro Ala Gly Ala Ala 
            260                 265                 270         


Leu Gln Ala Asp Gly Arg Ser Cys Thr Ala Ser Ala Thr Gln Ser Cys 
        275                 280                 285             


Asn Asp Leu Cys Glu His Phe Cys Val Pro Asn Pro Asp Gln Pro Gly 
    290                 295                 300                 


Ser Tyr Ser Cys Met Cys Glu Thr Gly Tyr Arg Leu Ala Ala Asp Gln 
305                 310                 315                 320 


His Arg Cys Glu Asp Val Asp Asp Cys Ile Leu Glu Pro Ser Pro Cys 
                325                 330                 335     


Pro Gln Arg Cys Val Asn Thr Gln Gly Gly Phe Glu Cys His Cys Tyr 
            340                 345                 350         


Pro Asn Tyr Asp Leu Val Asp Gly Glu Cys Val Glu Pro Val Asp Pro 
        355                 360                 365             


Cys Phe Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu Asn Gln Thr 
    370                 375                 380                 


Ser Tyr Leu Cys Val Cys Ala Glu Gly Phe Ala Pro Ile Pro His Glu 
385                 390                 395                 400 


Pro His Arg Cys Gln Met Phe Cys Asn Gln Thr Ala Cys Pro Ala Asp 
                405                 410                 415     


Cys Asp Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu Gly Tyr Ile 
            420                 425                 430         


Leu Asp Asp Gly Phe Ile Cys Thr Asp Ile Asp Glu Cys Glu Asn Gly 
        435                 440                 445             


Gly Phe Cys Ser Gly Val Cys His Asn Leu Pro Gly Thr Phe Glu Cys 
    450                 455                 460                 


Ile Cys Gly Pro Asp Ser Ala Leu Ala Arg His Ile Gly Thr Asp Cys 
465                 470                 475                 480 


Asp Ser Gly Lys Val Asp Gly Gly Asp Ser Gly Ser Gly Glu Pro Pro 
                485                 490                 495     


Pro Ser Pro Thr Pro Gly Ser Thr Leu Thr Pro Pro Ala Val Gly Leu 
            500                 505                 510         


Val His Ser Gly Leu Leu Ile Gly Ile Ser Ile Ala Ser Leu Cys Leu 
        515                 520                 525             


Val Val Ala Leu Leu Ala Leu Leu Cys His Leu Arg Lys Lys Gln Gly 
    530                 535                 540                 


Ala Ala Arg Ala Lys Met Glu Tyr Lys Cys Ala Ala Pro Ser Lys Glu 
545                 550                 555                 560 


Val Val Leu Gln His Val Arg Thr Glu Arg Thr Pro Gln Arg Leu 
                565                 570                 575 


<210>  109
<211>  764
<212>  PRT
<213>  Homo sapiens

<400>  109

Met Arg Pro Ala Asp Leu Leu Gln Leu Val Leu Leu Leu Asp Leu Pro 
1               5                   10                  15      


Arg Asp Leu Gly Gly Met Gly Cys Ser Ser Pro Pro Cys Glu Cys His 
            20                  25                  30          


Gln Glu Glu Asp Phe Arg Val Thr Cys Lys Asp Ile Gln Arg Ile Pro 
        35                  40                  45              


Ser Leu Pro Pro Ser Thr Gln Thr Leu Lys Leu Ile Glu Thr His Leu 
    50                  55                  60                  


Arg Thr Ile Pro Ser His Ala Phe Ser Asn Leu Pro Asn Ile Ser Arg 
65                  70                  75                  80  


Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu Ser His Ser 
                85                  90                  95      


Phe Tyr Asn Leu Ser Lys Val Thr His Ile Glu Ile Arg Asn Thr Arg 
            100                 105                 110         


Asn Leu Thr Tyr Ile Asp Pro Asp Ala Leu Lys Glu Leu Pro Leu Leu 
        115                 120                 125             


Lys Phe Leu Gly Ile Phe Asn Thr Gly Leu Lys Met Phe Pro Asp Leu 
    130                 135                 140                 


Thr Lys Val Tyr Ser Thr Asp Ile Phe Phe Ile Leu Glu Ile Thr Asp 
145                 150                 155                 160 


Asn Pro Tyr Met Thr Ser Ile Pro Val Asn Ala Phe Gln Gly Leu Cys 
                165                 170                 175     


Asn Glu Thr Leu Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Val 
            180                 185                 190         


Gln Gly Tyr Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu Asn 
        195                 200                 205             


Lys Asn Lys Tyr Leu Thr Val Ile Asp Lys Asp Ala Phe Gly Gly Val 
    210                 215                 220                 


Tyr Ser Gly Pro Ser Leu Leu Asp Val Ser Gln Thr Ser Val Thr Ala 
225                 230                 235                 240 


Leu Pro Ser Lys Gly Leu Glu His Leu Lys Glu Leu Ile Ala Arg Asn 
                245                 250                 255     


Thr Trp Thr Leu Lys Lys Leu Pro Leu Ser Leu Ser Phe Leu His Leu 
            260                 265                 270         


Thr Arg Ala Asp Leu Ser Tyr Pro Ser His Cys Cys Ala Phe Lys Asn 
        275                 280                 285             


Gln Lys Lys Ile Arg Gly Ile Leu Glu Ser Leu Met Cys Asn Glu Ser 
    290                 295                 300                 


Ser Met Gln Ser Leu Arg Gln Arg Lys Ser Val Asn Ala Leu Asn Ser 
305                 310                 315                 320 


Pro Leu His Gln Glu Tyr Glu Glu Asn Leu Gly Asp Ser Ile Val Gly 
                325                 330                 335     


Tyr Lys Glu Lys Ser Lys Phe Gln Asp Thr His Asn Asn Ala His Tyr 
            340                 345                 350         


Tyr Val Phe Phe Glu Glu Gln Glu Asp Glu Ile Ile Gly Phe Gly Gln 
        355                 360                 365             


Glu Leu Lys Asn Pro Gln Glu Glu Thr Leu Gln Ala Phe Asp Ser His 
    370                 375                 380                 


Tyr Asp Tyr Thr Ile Cys Gly Asp Ser Glu Asp Met Val Cys Thr Pro 
385                 390                 395                 400 


Lys Ser Asp Glu Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Lys Phe 
                405                 410                 415     


Leu Arg Ile Val Val Trp Phe Val Ser Leu Leu Ala Leu Leu Gly Asn 
            420                 425                 430         


Val Phe Val Leu Leu Ile Leu Leu Thr Ser His Tyr Lys Leu Asn Val 
        435                 440                 445             


Pro Arg Phe Leu Met Cys Asn Leu Ala Phe Ala Asp Phe Cys Met Gly 
    450                 455                 460                 


Met Tyr Leu Leu Leu Ile Ala Ser Val Asp Leu Tyr Thr His Ser Glu 
465                 470                 475                 480 


Tyr Tyr Asn His Ala Ile Asp Trp Gln Thr Gly Pro Gly Cys Asn Thr 
                485                 490                 495     


Ala Gly Phe Phe Thr Val Phe Ala Ser Glu Leu Ser Val Tyr Thr Leu 
            500                 505                 510         


Thr Val Ile Thr Leu Glu Arg Trp Tyr Ala Ile Thr Phe Ala Met Arg 
        515                 520                 525             


Leu Asp Arg Lys Ile Arg Leu Arg His Ala Cys Ala Ile Met Val Gly 
    530                 535                 540                 


Gly Trp Val Cys Cys Phe Leu Leu Ala Leu Leu Pro Leu Val Gly Ile 
545                 550                 555                 560 


Ser Ser Tyr Ala Lys Val Ser Ile Cys Leu Pro Met Asp Thr Glu Thr 
                565                 570                 575     


Pro Leu Ala Leu Ala Tyr Ile Val Phe Val Leu Thr Leu Asn Ile Val 
            580                 585                 590         


Ala Phe Val Ile Val Cys Cys Cys Tyr Val Lys Ile Tyr Ile Thr Val 
        595                 600                 605             


Arg Asn Pro Gln Tyr Asn Pro Gly Asp Lys Asp Thr Lys Ile Ala Lys 
    610                 615                 620                 


Arg Met Ala Val Leu Ile Phe Thr Asp Phe Ile Cys Met Ala Pro Ile 
625                 630                 635                 640 


Ser Phe Tyr Ala Leu Ser Ala Ile Leu Asn Lys Pro Leu Ile Thr Val 
                645                 650                 655     


Ser Asn Ser Lys Ile Leu Leu Val Leu Phe Tyr Pro Leu Asn Ser Cys 
            660                 665                 670         


Ala Asn Pro Phe Leu Tyr Ala Ile Phe Thr Lys Ala Phe Gln Arg Asp 
        675                 680                 685             


Val Phe Ile Leu Leu Ser Lys Phe Gly Ile Cys Lys Arg Gln Ala Gln 
    690                 695                 700                 


Ala Tyr Arg Gly Gln Arg Val Pro Pro Lys Asn Ser Thr Asp Ile Gln 
705                 710                 715                 720 


Val Gln Lys Val Thr His Glu Met Arg Gln Gly Leu His Asn Met Glu 
                725                 730                 735     


Asp Val Tyr Glu Leu Ile Glu Asn Ser His Leu Thr Pro Lys Lys Gln 
            740                 745                 750         


Gly Gln Ile Ser Glu Glu Tyr Met Gln Thr Val Leu 
        755                 760                 


<210>  110
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Leu Leu Ala Val Leu Tyr Cys Leu Leu Trp Ser Phe Gln Thr Ser 
1               5                   10                  15      


Ala Gly His Phe Pro Arg Ala Cys Val Ser Ser Lys Asn Leu Met Glu 
            20                  25                  30          


Lys Glu Cys Cys Pro Pro Trp Ser Gly Asp Arg Ser Pro Cys Gly Gln 
        35                  40                  45              


Leu Ser Gly Arg Gly Ser Cys Gln Asn Ile Leu Leu Ser Asn Ala Pro 
    50                  55                  60                  


Leu Gly Pro Gln Phe Pro Phe Thr Gly Val Asp Asp Arg Glu Ser Trp 
65                  70                  75                  80  


Pro Ser Val Phe Tyr Asn Arg Thr Cys Gln Cys Ser Gly Asn Phe Met 
                85                  90                  95      


Gly Phe Asn Cys Gly Asn Cys Lys Phe Gly Phe Trp Gly Pro Asn Cys 
            100                 105                 110         


Thr Glu Arg Arg Leu Leu Val Arg Arg Asn Ile Phe Asp Leu Ser Ala 
        115                 120                 125             


Pro Glu Lys Asp Lys Phe Phe Ala Tyr Leu Thr Leu Ala Lys His Thr 
    130                 135                 140                 


Ile Ser Ser Asp Tyr Val Ile Pro Ile Gly Thr Tyr Gly Gln Met Lys 
145                 150                 155                 160 


Asn Gly Ser Thr Pro Met Phe Asn Asp Ile Asn Ile Tyr Asp Leu Phe 
                165                 170                 175     


Val Trp Met His Tyr Tyr Val Ser Met Asp Ala Leu Leu Gly Gly Ser 
            180                 185                 190         


Glu Ile Trp Arg Asp Ile Asp Phe Ala His Glu Ala Pro Ala Phe Leu 
        195                 200                 205             


Pro Trp His Arg Leu Phe Leu Leu Arg Trp Glu Gln Glu Ile Gln Lys 
    210                 215                 220                 


Leu Thr Gly Asp Glu Asn Phe Thr Ile Pro Tyr Trp Asp Trp Arg Asp 
225                 230                 235                 240 


Ala Glu Lys Cys Asp Ile Cys Thr Asp Glu Tyr Met Gly Gly Gln His 
                245                 250                 255     


Pro Thr Asn Pro Asn Leu Leu Ser Pro Ala Ser Phe Phe Ser Ser Trp 
            260                 265                 270         


Gln Ile Val Cys Ser Arg Leu Glu Glu Tyr Asn Ser His Gln Ser Leu 
        275                 280                 285             


Cys Asn Gly Thr Pro Glu Gly Pro Leu Arg Arg Asn Pro Gly Asn His 
    290                 295                 300                 


Asp Lys Ser Arg Thr Pro Arg Leu Pro Ser Ser Ala Asp Val Glu Phe 
305                 310                 315                 320 


Cys Leu Ser Leu Thr Gln Tyr Glu Ser Gly Ser Met Asp Lys Ala Ala 
                325                 330                 335     


Asn Phe Ser Phe Arg Asn Thr Leu Glu Gly Phe Ala Ser Pro Leu Thr 
            340                 345                 350         


Gly Ile Ala Asp Ala Ser Gln Ser Ser Met His Asn Ala Leu His Ile 
        355                 360                 365             


Tyr Met Asn Gly Thr Met Ser Gln Val Gln Gly Ser Ala Asn Asp Pro 
    370                 375                 380                 


Ile Phe Leu Leu His His Ala Phe Val Asp Ser Ile Phe Glu Gln Trp 
385                 390                 395                 400 


Leu Arg Arg His Arg Pro Leu Gln Glu Val Tyr Pro Glu Ala Asn Ala 
                405                 410                 415     


Pro Ile Gly His Asn Arg Glu Ser Tyr Met Val Pro Phe Ile Pro Leu 
            420                 425                 430         


Tyr Arg Asn Gly Asp Phe Phe Ile Ser Ser Lys Asp Leu Gly Tyr Asp 
        435                 440                 445             


Tyr Ser Tyr Leu Gln Asp Ser Asp Pro Asp Ser Phe Gln Asp Tyr Ile 
    450                 455                 460                 


Lys Ser Tyr Leu Glu Gln Ala Ser Arg Ile Trp Ser Trp Leu Leu Gly 
465                 470                 475                 480 


Ala Ala Met Val Gly Ala Val Leu Thr Ala Leu Leu Ala Gly Leu Val 
                485                 490                 495     


Ser Leu Leu Cys Arg His Lys Arg Lys Gln Leu Pro Glu Glu Lys Gln 
            500                 505                 510         


Pro Leu Leu Met Glu Lys Glu Asp Tyr His Ser Leu Tyr Gln Ser His 
        515                 520                 525             


Leu 
    


<210>  111
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Gln Asp Pro Ala Ser Thr Cys Val Pro Glu Pro Ala Ser Gln His 
1               5                   10                  15      


Thr Leu Arg Ser Gly Pro Gly Cys Leu Gln Gln Pro Glu Gln Gln Gly 
            20                  25                  30          


Val Arg Asp Pro Gly Gly Ile Trp Ala Lys Leu Gly Ala Ala Glu Ala 
        35                  40                  45              


Ser Ala Glu Arg Leu Gln Gly Arg Arg Ser Arg Gly Ala Ser Gly Ser 
    50                  55                  60                  


Glu Pro Gln Gln Met Gly Ser Asp Val Arg Asp Leu Asn Ala Leu Leu 
65                  70                  75                  80  


Pro Ala Val Pro Ser Leu Gly Gly Gly Gly Gly Cys Ala Leu Pro Val 
                85                  90                  95      


Ser Gly Ala Ala Gln Trp Ala Pro Val Leu Asp Phe Ala Pro Pro Gly 
            100                 105                 110         


Ala Ser Ala Tyr Gly Ser Leu Gly Gly Pro Ala Pro Pro Pro Ala Pro 
        115                 120                 125             


Pro Pro Pro Pro Pro Pro Pro Pro His Ser Phe Ile Lys Gln Glu Pro 
    130                 135                 140                 


Ser Trp Gly Gly Ala Glu Pro His Glu Glu Gln Cys Leu Ser Ala Phe 
145                 150                 155                 160 


Thr Val His Phe Ser Gly Gln Phe Thr Gly Thr Ala Gly Ala Cys Arg 
                165                 170                 175     


Tyr Gly Pro Phe Gly Pro Pro Pro Pro Ser Gln Ala Ser Ser Gly Gln 
            180                 185                 190         


Ala Arg Met Phe Pro Asn Ala Pro Tyr Leu Pro Ser Cys Leu Glu Ser 
        195                 200                 205             


Gln Pro Ala Ile Arg Asn Gln Gly Tyr Ser Thr Val Thr Phe Asp Gly 
    210                 215                 220                 


Thr Pro Ser Tyr Gly His Thr Pro Ser His His Ala Ala Gln Phe Pro 
225                 230                 235                 240 


Asn His Ser Phe Lys His Glu Asp Pro Met Gly Gln Gln Gly Ser Leu 
                245                 250                 255     


Gly Glu Gln Gln Tyr Ser Val Pro Pro Pro Val Tyr Gly Cys His Thr 
            260                 265                 270         


Pro Thr Asp Ser Cys Thr Gly Ser Gln Ala Leu Leu Leu Arg Thr Pro 
        275                 280                 285             


Tyr Ser Ser Asp Asn Leu Tyr Gln Met Thr Ser Gln Leu Glu Cys Met 
    290                 295                 300                 


Thr Trp Asn Gln Met Asn Leu Gly Ala Thr Leu Lys Gly His Ser Thr 
305                 310                 315                 320 


Gly Tyr Glu Ser Asp Asn His Thr Thr Pro Ile Leu Cys Gly Ala Gln 
                325                 330                 335     


Tyr Arg Ile His Thr His Gly Val Phe Arg Gly Ile Gln Asp Val Arg 
            340                 345                 350         


Arg Val Pro Gly Val Ala Pro Thr Leu Val Arg Ser Ala Ser Glu Thr 
        355                 360                 365             


Ser Glu Lys Arg Pro Phe Met Cys Ala Tyr Pro Gly Cys Asn Lys Arg 
    370                 375                 380                 


Tyr Phe Lys Leu Ser His Leu Gln Met His Ser Arg Lys His Thr Gly 
385                 390                 395                 400 


Glu Lys Pro Tyr Gln Cys Asp Phe Lys Asp Cys Glu Arg Arg Phe Ser 
                405                 410                 415     


Arg Ser Asp Gln Leu Lys Arg His Gln Arg Arg His Thr Gly Val Lys 
            420                 425                 430         


Pro Phe Gln Cys Lys Thr Cys Gln Arg Lys Phe Ser Arg Ser Asp His 
        435                 440                 445             


Leu Lys Thr His Thr Arg Thr His Thr Gly Glu Lys Pro Phe Ser Cys 
    450                 455                 460                 


Arg Trp Pro Ser Cys Gln Lys Lys Phe Ala Arg Ser Asp Glu Leu Val 
465                 470                 475                 480 


Arg His His Asn Met His Gln Arg Asn Met Thr Lys Leu Gln Leu Ala 
                485                 490                 495     


Leu 
    


<210>  112
<211>  667
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Glu Thr Leu Glu Ser Glu Leu Thr Cys Pro Ile Cys Leu Glu Leu 
1               5                   10                  15      


Phe Glu Asp Pro Leu Leu Leu Pro Cys Ala His Ser Leu Cys Phe Asn 
            20                  25                  30          


Cys Ala His Arg Ile Leu Val Ser His Cys Ala Thr Asn Glu Ser Val 
        35                  40                  45              


Glu Ser Ile Thr Ala Phe Gln Cys Pro Thr Cys Arg His Val Ile Thr 
    50                  55                  60                  


Leu Ser Gln Arg Gly Leu Asp Gly Leu Lys Arg Asn Val Thr Leu Gln 
65                  70                  75                  80  


Asn Ile Ile Asp Arg Phe Gln Lys Ala Ser Val Ser Gly Pro Asn Ser 
                85                  90                  95      


Pro Ser Glu Thr Arg Arg Glu Arg Ala Phe Asp Ala Asn Thr Met Thr 
            100                 105                 110         


Ser Ala Glu Lys Val Leu Cys Gln Phe Cys Asp Gln Asp Pro Ala Gln 
        115                 120                 125             


Asp Ala Val Lys Thr Cys Val Thr Cys Glu Val Ser Tyr Cys Asp Glu 
    130                 135                 140                 


Cys Leu Lys Ala Thr His Pro Asn Lys Lys Pro Phe Thr Gly His Arg 
145                 150                 155                 160 


Leu Ile Glu Pro Ile Pro Asp Ser His Ile Arg Gly Leu Met Cys Leu 
                165                 170                 175     


Glu His Glu Asp Glu Lys Val Asn Met Tyr Cys Val Thr Asp Asp Gln 
            180                 185                 190         


Leu Ile Cys Ala Leu Cys Lys Leu Val Gly Arg His Arg Asp His Gln 
        195                 200                 205             


Val Ala Ala Leu Ser Glu Arg Tyr Asp Lys Leu Lys Gln Asn Leu Glu 
    210                 215                 220                 


Ser Asn Leu Thr Asn Leu Ile Lys Arg Asn Thr Glu Leu Glu Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Leu Ile Gln Thr Cys Gln His Val Glu Val Asn Ala Ser 
                245                 250                 255     


Arg Gln Glu Ala Lys Leu Thr Glu Glu Cys Asp Leu Leu Ile Glu Ile 
            260                 265                 270         


Ile Gln Gln Arg Arg Gln Ile Ile Gly Thr Lys Ile Lys Glu Gly Lys 
        275                 280                 285             


Val Met Arg Leu Arg Lys Leu Ala Gln Gln Ile Ala Asn Cys Lys Gln 
    290                 295                 300                 


Cys Ile Glu Arg Ser Ala Ser Leu Ile Ser Gln Ala Glu His Ser Leu 
305                 310                 315                 320 


Lys Glu Asn Asp His Ala Arg Phe Leu Gln Thr Ala Lys Asn Ile Thr 
                325                 330                 335     


Glu Arg Val Ser Met Ala Thr Ala Ser Ser Gln Val Leu Ile Pro Glu 
            340                 345                 350         


Ile Asn Leu Asn Asp Thr Phe Asp Thr Phe Ala Leu Asp Phe Ser Arg 
        355                 360                 365             


Glu Lys Lys Leu Leu Glu Cys Leu Asp Tyr Leu Thr Ala Pro Asn Pro 
    370                 375                 380                 


Pro Thr Ile Arg Glu Glu Leu Cys Thr Ala Ser Tyr Asp Thr Ile Thr 
385                 390                 395                 400 


Val His Trp Thr Ser Asp Asp Glu Phe Ser Val Val Ser Tyr Glu Leu 
                405                 410                 415     


Gln Tyr Thr Ile Phe Thr Gly Gln Ala Asn Val Val Ser Leu Cys Asn 
            420                 425                 430         


Ser Ala Asp Ser Trp Met Ile Val Pro Asn Ile Lys Gln Asn His Tyr 
        435                 440                 445             


Thr Val His Gly Leu Gln Ser Gly Thr Lys Tyr Ile Phe Met Val Lys 
    450                 455                 460                 


Ala Ile Asn Gln Ala Gly Ser Arg Ser Ser Glu Pro Gly Lys Leu Lys 
465                 470                 475                 480 


Thr Asn Ser Gln Pro Phe Lys Leu Asp Pro Lys Ser Ala His Arg Lys 
                485                 490                 495     


Leu Lys Val Ser His Asp Asn Leu Thr Val Glu Arg Asp Glu Ser Ser 
            500                 505                 510         


Ser Lys Lys Ser His Thr Pro Glu Arg Phe Thr Ser Gln Gly Ser Tyr 
        515                 520                 525             


Gly Val Ala Gly Asn Val Phe Ile Asp Ser Gly Arg His Tyr Trp Glu 
    530                 535                 540                 


Val Val Ile Ser Gly Ser Thr Trp Tyr Ala Ile Gly Leu Ala Tyr Lys 
545                 550                 555                 560 


Ser Ala Pro Lys His Glu Trp Ile Gly Lys Asn Ser Ala Ser Trp Ala 
                565                 570                 575     


Leu Cys Arg Cys Asn Asn Asn Trp Val Val Arg His Asn Ser Lys Glu 
            580                 585                 590         


Ile Pro Ile Glu Pro Ala Pro His Leu Arg Arg Val Gly Ile Leu Leu 
        595                 600                 605             


Asp Tyr Asp Asn Gly Ser Ile Ala Phe Tyr Asp Ala Leu Asn Ser Ile 
    610                 615                 620                 


His Leu Tyr Thr Phe Asp Val Ala Phe Ala Gln Pro Val Cys Pro Thr 
625                 630                 635                 640 


Phe Thr Val Trp Asn Lys Cys Leu Thr Ile Ile Thr Gly Leu Pro Ile 
                645                 650                 655     


Pro Asp His Leu Asp Cys Thr Glu Gln Leu Pro 
            660                 665         


<210>  113
<211>  485
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Glu Leu Glu Val Arg Arg Val Arg Gln Ala Phe Leu Ser Gly Arg 
1               5                   10                  15      


Ser Arg Pro Leu Arg Phe Arg Leu Gln Gln Leu Glu Ala Leu Arg Arg 
            20                  25                  30          


Met Val Gln Glu Arg Glu Lys Asp Ile Leu Thr Ala Ile Ala Ala Asp 
        35                  40                  45              


Leu Cys Lys Ser Glu Phe Asn Val Tyr Ser Gln Glu Val Ile Thr Val 
    50                  55                  60                  


Leu Gly Glu Ile Asp Phe Met Leu Glu Asn Leu Pro Glu Trp Val Thr 
65                  70                  75                  80  


Ala Lys Pro Val Lys Lys Asn Val Leu Thr Met Leu Asp Glu Ala Tyr 
                85                  90                  95      


Ile Gln Pro Gln Pro Leu Gly Val Val Leu Ile Ile Gly Ala Trp Asn 
            100                 105                 110         


Tyr Pro Phe Val Leu Thr Ile Gln Pro Leu Ile Gly Ala Ile Ala Ala 
        115                 120                 125             


Gly Asn Ala Val Ile Ile Lys Pro Ser Glu Leu Ser Glu Asn Thr Ala 
    130                 135                 140                 


Lys Ile Leu Ala Lys Leu Leu Pro Gln Tyr Leu Asp Gln Asp Leu Tyr 
145                 150                 155                 160 


Ile Val Ile Asn Gly Gly Val Glu Glu Thr Thr Glu Leu Leu Lys Gln 
                165                 170                 175     


Arg Phe Asp His Ile Phe Tyr Thr Gly Asn Thr Ala Val Gly Lys Ile 
            180                 185                 190         


Val Met Glu Ala Ala Ala Lys His Leu Thr Pro Val Thr Leu Glu Leu 
        195                 200                 205             


Gly Gly Lys Ser Pro Cys Tyr Ile Asp Lys Asp Cys Asp Leu Asp Ile 
    210                 215                 220                 


Val Cys Arg Arg Ile Thr Trp Gly Lys Tyr Met Asn Cys Gly Gln Thr 
225                 230                 235                 240 


Cys Ile Ala Pro Asp Tyr Ile Leu Cys Glu Ala Ser Leu Gln Asn Gln 
                245                 250                 255     


Ile Val Trp Lys Ile Lys Glu Thr Val Lys Glu Phe Tyr Gly Glu Asn 
            260                 265                 270         


Ile Lys Glu Ser Pro Asp Tyr Glu Arg Ile Ile Asn Leu Arg His Phe 
        275                 280                 285             


Lys Arg Ile Leu Ser Leu Leu Glu Gly Gln Lys Ile Ala Phe Gly Gly 
    290                 295                 300                 


Glu Thr Asp Glu Ala Thr Arg Tyr Ile Ala Pro Thr Val Leu Thr Asp 
305                 310                 315                 320 


Val Asp Pro Lys Thr Lys Val Met Gln Glu Glu Ile Phe Gly Pro Ile 
                325                 330                 335     


Leu Pro Ile Val Pro Val Lys Asn Val Asp Glu Ala Ile Asn Phe Ile 
            340                 345                 350         


Asn Glu Arg Glu Lys Pro Leu Ala Leu Tyr Val Phe Ser His Asn His 
        355                 360                 365             


Lys Leu Ile Lys Arg Met Ile Asp Glu Thr Ser Ser Gly Gly Val Thr 
    370                 375                 380                 


Gly Asn Asp Val Ile Met His Phe Thr Leu Asn Ser Phe Pro Phe Gly 
385                 390                 395                 400 


Gly Val Gly Ser Ser Gly Met Gly Ala Tyr His Gly Lys His Ser Phe 
                405                 410                 415     


Asp Thr Phe Ser His Gln Arg Pro Cys Leu Leu Lys Ser Leu Lys Arg 
            420                 425                 430         


Glu Gly Ala Asn Lys Leu Arg Tyr Pro Pro Asn Ser Gln Ser Lys Val 
        435                 440                 445             


Asp Trp Gly Lys Phe Phe Leu Leu Lys Arg Phe Asn Lys Glu Lys Leu 
    450                 455                 460                 


Gly Leu Leu Leu Leu Thr Phe Leu Gly Ile Val Ala Ala Val Leu Val 
465                 470                 475                 480 


Lys Ala Glu Tyr Tyr 
                485 


<210>  114
<211>  4563
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Asp Pro Pro Arg Pro Ala Leu Leu Ala Leu Leu Ala Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ala Gly Ala Arg Ala Glu Glu Glu Met Leu 
            20                  25                  30          


Glu Asn Val Ser Leu Val Cys Pro Lys Asp Ala Thr Arg Phe Lys His 
        35                  40                  45              


Leu Arg Lys Tyr Thr Tyr Asn Tyr Glu Ala Glu Ser Ser Ser Gly Val 
    50                  55                  60                  


Pro Gly Thr Ala Asp Ser Arg Ser Ala Thr Arg Ile Asn Cys Lys Val 
65                  70                  75                  80  


Glu Leu Glu Val Pro Gln Leu Cys Ser Phe Ile Leu Lys Thr Ser Gln 
                85                  90                  95      


Cys Thr Leu Lys Glu Val Tyr Gly Phe Asn Pro Glu Gly Lys Ala Leu 
            100                 105                 110         


Leu Lys Lys Thr Lys Asn Ser Glu Glu Phe Ala Ala Ala Met Ser Arg 
        115                 120                 125             


Tyr Glu Leu Lys Leu Ala Ile Pro Glu Gly Lys Gln Val Phe Leu Tyr 
    130                 135                 140                 


Pro Glu Lys Asp Glu Pro Thr Tyr Ile Leu Asn Ile Lys Arg Gly Ile 
145                 150                 155                 160 


Ile Ser Ala Leu Leu Val Pro Pro Glu Thr Glu Glu Ala Lys Gln Val 
                165                 170                 175     


Leu Phe Leu Asp Thr Val Tyr Gly Asn Cys Ser Thr His Phe Thr Val 
            180                 185                 190         


Lys Thr Arg Lys Gly Asn Val Ala Thr Glu Ile Ser Thr Glu Arg Asp 
        195                 200                 205             


Leu Gly Gln Cys Asp Arg Phe Lys Pro Ile Arg Thr Gly Ile Ser Pro 
    210                 215                 220                 


Leu Ala Leu Ile Lys Gly Met Thr Arg Pro Leu Ser Thr Leu Ile Ser 
225                 230                 235                 240 


Ser Ser Gln Ser Cys Gln Tyr Thr Leu Asp Ala Lys Arg Lys His Val 
                245                 250                 255     


Ala Glu Ala Ile Cys Lys Glu Gln His Leu Phe Leu Pro Phe Ser Tyr 
            260                 265                 270         


Lys Asn Lys Tyr Gly Met Val Ala Gln Val Thr Gln Thr Leu Lys Leu 
        275                 280                 285             


Glu Asp Thr Pro Lys Ile Asn Ser Arg Phe Phe Gly Glu Gly Thr Lys 
    290                 295                 300                 


Lys Met Gly Leu Ala Phe Glu Ser Thr Lys Ser Thr Ser Pro Pro Lys 
305                 310                 315                 320 


Gln Ala Glu Ala Val Leu Lys Thr Leu Gln Glu Leu Lys Lys Leu Thr 
                325                 330                 335     


Ile Ser Glu Gln Asn Ile Gln Arg Ala Asn Leu Phe Asn Lys Leu Val 
            340                 345                 350         


Thr Glu Leu Arg Gly Leu Ser Asp Glu Ala Val Thr Ser Leu Leu Pro 
        355                 360                 365             


Gln Leu Ile Glu Val Ser Ser Pro Ile Thr Leu Gln Ala Leu Val Gln 
    370                 375                 380                 


Cys Gly Gln Pro Gln Cys Ser Thr His Ile Leu Gln Trp Leu Lys Arg 
385                 390                 395                 400 


Val His Ala Asn Pro Leu Leu Ile Asp Val Val Thr Tyr Leu Val Ala 
                405                 410                 415     


Leu Ile Pro Glu Pro Ser Ala Gln Gln Leu Arg Glu Ile Phe Asn Met 
            420                 425                 430         


Ala Arg Asp Gln Arg Ser Arg Ala Thr Leu Tyr Ala Leu Ser His Ala 
        435                 440                 445             


Val Asn Asn Tyr His Lys Thr Asn Pro Thr Gly Thr Gln Glu Leu Leu 
    450                 455                 460                 


Asp Ile Ala Asn Tyr Leu Met Glu Gln Ile Gln Asp Asp Cys Thr Gly 
465                 470                 475                 480 


Asp Glu Asp Tyr Thr Tyr Leu Ile Leu Arg Val Ile Gly Asn Met Gly 
                485                 490                 495     


Gln Thr Met Glu Gln Leu Thr Pro Glu Leu Lys Ser Ser Ile Leu Lys 
            500                 505                 510         


Cys Val Gln Ser Thr Lys Pro Ser Leu Met Ile Gln Lys Ala Ala Ile 
        515                 520                 525             


Gln Ala Leu Arg Lys Met Glu Pro Lys Asp Lys Asp Gln Glu Val Leu 
    530                 535                 540                 


Leu Gln Thr Phe Leu Asp Asp Ala Ser Pro Gly Asp Lys Arg Leu Ala 
545                 550                 555                 560 


Ala Tyr Leu Met Leu Met Arg Ser Pro Ser Gln Ala Asp Ile Asn Lys 
                565                 570                 575     


Ile Val Gln Ile Leu Pro Trp Glu Gln Asn Glu Gln Val Lys Asn Phe 
            580                 585                 590         


Val Ala Ser His Ile Ala Asn Ile Leu Asn Ser Glu Glu Leu Asp Ile 
        595                 600                 605             


Gln Asp Leu Lys Lys Leu Val Lys Glu Ala Leu Lys Glu Ser Gln Leu 
    610                 615                 620                 


Pro Thr Val Met Asp Phe Arg Lys Phe Ser Arg Asn Tyr Gln Leu Tyr 
625                 630                 635                 640 


Lys Ser Val Ser Leu Pro Ser Leu Asp Pro Ala Ser Ala Lys Ile Glu 
                645                 650                 655     


Gly Asn Leu Ile Phe Asp Pro Asn Asn Tyr Leu Pro Lys Glu Ser Met 
            660                 665                 670         


Leu Lys Thr Thr Leu Thr Ala Phe Gly Phe Ala Ser Ala Asp Leu Ile 
        675                 680                 685             


Glu Ile Gly Leu Glu Gly Lys Gly Phe Glu Pro Thr Leu Glu Ala Leu 
    690                 695                 700                 


Phe Gly Lys Gln Gly Phe Phe Pro Asp Ser Val Asn Lys Ala Leu Tyr 
705                 710                 715                 720 


Trp Val Asn Gly Gln Val Pro Asp Gly Val Ser Lys Val Leu Val Asp 
                725                 730                 735     


His Phe Gly Tyr Thr Lys Asp Asp Lys His Glu Gln Asp Met Val Asn 
            740                 745                 750         


Gly Ile Met Leu Ser Val Glu Lys Leu Ile Lys Asp Leu Lys Ser Lys 
        755                 760                 765             


Glu Val Pro Glu Ala Arg Ala Tyr Leu Arg Ile Leu Gly Glu Glu Leu 
    770                 775                 780                 


Gly Phe Ala Ser Leu His Asp Leu Gln Leu Leu Gly Lys Leu Leu Leu 
785                 790                 795                 800 


Met Gly Ala Arg Thr Leu Gln Gly Ile Pro Gln Met Ile Gly Glu Val 
                805                 810                 815     


Ile Arg Lys Gly Ser Lys Asn Asp Phe Phe Leu His Tyr Ile Phe Met 
            820                 825                 830         


Glu Asn Ala Phe Glu Leu Pro Thr Gly Ala Gly Leu Gln Leu Gln Ile 
        835                 840                 845             


Ser Ser Ser Gly Val Ile Ala Pro Gly Ala Lys Ala Gly Val Lys Leu 
    850                 855                 860                 


Glu Val Ala Asn Met Gln Ala Glu Leu Val Ala Lys Pro Ser Val Ser 
865                 870                 875                 880 


Val Glu Phe Val Thr Asn Met Gly Ile Ile Ile Pro Asp Phe Ala Arg 
                885                 890                 895     


Ser Gly Val Gln Met Asn Thr Asn Phe Phe His Glu Ser Gly Leu Glu 
            900                 905                 910         


Ala His Val Ala Leu Lys Ala Gly Lys Leu Lys Phe Ile Ile Pro Ser 
        915                 920                 925             


Pro Lys Arg Pro Val Lys Leu Leu Ser Gly Gly Asn Thr Leu His Leu 
    930                 935                 940                 


Val Ser Thr Thr Lys Thr Glu Val Ile Pro Pro Leu Ile Glu Asn Arg 
945                 950                 955                 960 


Gln Ser Trp Ser Val Cys Lys Gln Val Phe Pro Gly Leu Asn Tyr Cys 
                965                 970                 975     


Thr Ser Gly Ala Tyr Ser Asn Ala Ser Ser Thr Asp Ser Ala Ser Tyr 
            980                 985                 990         


Tyr Pro Leu Thr Gly Asp Thr Arg  Leu Glu Leu Glu Leu  Arg Pro Thr 
        995                 1000                 1005             


Gly Glu  Ile Glu Gln Tyr Ser  Val Ser Ala Thr Tyr  Glu Leu Gln 
    1010                 1015                 1020             


Arg Glu  Asp Arg Ala Leu Val  Asp Thr Leu Lys Phe  Val Thr Gln 
    1025                 1030                 1035             


Ala Glu  Gly Ala Lys Gln Thr  Glu Ala Thr Met Thr  Phe Lys Tyr 
    1040                 1045                 1050             


Asn Arg  Gln Ser Met Thr Leu  Ser Ser Glu Val Gln  Ile Pro Asp 
    1055                 1060                 1065             


Phe Asp  Val Asp Leu Gly Thr  Ile Leu Arg Val Asn  Asp Glu Ser 
    1070                 1075                 1080             


Thr Glu  Gly Lys Thr Ser Tyr  Arg Leu Thr Leu Asp  Ile Gln Asn 
    1085                 1090                 1095             


Lys Lys  Ile Thr Glu Val Ala  Leu Met Gly His Leu  Ser Cys Asp 
    1100                 1105                 1110             


Thr Lys  Glu Glu Arg Lys Ile  Lys Gly Val Ile Ser  Ile Pro Arg 
    1115                 1120                 1125             


Leu Gln  Ala Glu Ala Arg Ser  Glu Ile Leu Ala His  Trp Ser Pro 
    1130                 1135                 1140             


Ala Lys  Leu Leu Leu Gln Met  Asp Ser Ser Ala Thr  Ala Tyr Gly 
    1145                 1150                 1155             


Ser Thr  Val Ser Lys Arg Val  Ala Trp His Tyr Asp  Glu Glu Lys 
    1160                 1165                 1170             


Ile Glu  Phe Glu Trp Asn Thr  Gly Thr Asn Val Asp  Thr Lys Lys 
    1175                 1180                 1185             


Met Thr  Ser Asn Phe Pro Val  Asp Leu Ser Asp Tyr  Pro Lys Ser 
    1190                 1195                 1200             


Leu His  Met Tyr Ala Asn Arg  Leu Leu Asp His Arg  Val Pro Gln 
    1205                 1210                 1215             


Thr Asp  Met Thr Phe Arg His  Val Gly Ser Lys Leu  Ile Val Ala 
    1220                 1225                 1230             


Met Ser  Ser Trp Leu Gln Lys  Ala Ser Gly Ser Leu  Pro Tyr Thr 
    1235                 1240                 1245             


Gln Thr  Leu Gln Asp His Leu  Asn Ser Leu Lys Glu  Phe Asn Leu 
    1250                 1255                 1260             


Gln Asn  Met Gly Leu Pro Asp  Phe His Ile Pro Glu  Asn Leu Phe 
    1265                 1270                 1275             


Leu Lys  Ser Asp Gly Arg Val  Lys Tyr Thr Leu Asn  Lys Asn Ser 
    1280                 1285                 1290             


Leu Lys  Ile Glu Ile Pro Leu  Pro Phe Gly Gly Lys  Ser Ser Arg 
    1295                 1300                 1305             


Asp Leu  Lys Met Leu Glu Thr  Val Arg Thr Pro Ala  Leu His Phe 
    1310                 1315                 1320             


Lys Ser  Val Gly Phe His Leu  Pro Ser Arg Glu Phe  Gln Val Pro 
    1325                 1330                 1335             


Thr Phe  Thr Ile Pro Lys Leu  Tyr Gln Leu Gln Val  Pro Leu Leu 
    1340                 1345                 1350             


Gly Val  Leu Asp Leu Ser Thr  Asn Val Tyr Ser Asn  Leu Tyr Asn 
    1355                 1360                 1365             


Trp Ser  Ala Ser Tyr Ser Gly  Gly Asn Thr Ser Thr  Asp His Phe 
    1370                 1375                 1380             


Ser Leu  Arg Ala Arg Tyr His  Met Lys Ala Asp Ser  Val Val Asp 
    1385                 1390                 1395             


Leu Leu  Ser Tyr Asn Val Gln  Gly Ser Gly Glu Thr  Thr Tyr Asp 
    1400                 1405                 1410             


His Lys  Asn Thr Phe Thr Leu  Ser Cys Asp Gly Ser  Leu Arg His 
    1415                 1420                 1425             


Lys Phe  Leu Asp Ser Asn Ile  Lys Phe Ser His Val  Glu Lys Leu 
    1430                 1435                 1440             


Gly Asn  Asn Pro Val Ser Lys  Gly Leu Leu Ile Phe  Asp Ala Ser 
    1445                 1450                 1455             


Ser Ser  Trp Gly Pro Gln Met  Ser Ala Ser Val His  Leu Asp Ser 
    1460                 1465                 1470             


Lys Lys  Lys Gln His Leu Phe  Val Lys Glu Val Lys  Ile Asp Gly 
    1475                 1480                 1485             


Gln Phe  Arg Val Ser Ser Phe  Tyr Ala Lys Gly Thr  Tyr Gly Leu 
    1490                 1495                 1500             


Ser Cys  Gln Arg Asp Pro Asn  Thr Gly Arg Leu Asn  Gly Glu Ser 
    1505                 1510                 1515             


Asn Leu  Arg Phe Asn Ser Ser  Tyr Leu Gln Gly Thr  Asn Gln Ile 
    1520                 1525                 1530             


Thr Gly  Arg Tyr Glu Asp Gly  Thr Leu Ser Leu Thr  Ser Thr Ser 
    1535                 1540                 1545             


Asp Leu  Gln Ser Gly Ile Ile  Lys Asn Thr Ala Ser  Leu Lys Tyr 
    1550                 1555                 1560             


Glu Asn  Tyr Glu Leu Thr Leu  Lys Ser Asp Thr Asn  Gly Lys Tyr 
    1565                 1570                 1575             


Lys Asn  Phe Ala Thr Ser Asn  Lys Met Asp Met Thr  Phe Ser Lys 
    1580                 1585                 1590             


Gln Asn  Ala Leu Leu Arg Ser  Glu Tyr Gln Ala Asp  Tyr Glu Ser 
    1595                 1600                 1605             


Leu Arg  Phe Phe Ser Leu Leu  Ser Gly Ser Leu Asn  Ser His Gly 
    1610                 1615                 1620             


Leu Glu  Leu Asn Ala Asp Ile  Leu Gly Thr Asp Lys  Ile Asn Ser 
    1625                 1630                 1635             


Gly Ala  His Lys Ala Thr Leu  Arg Ile Gly Gln Asp  Gly Ile Ser 
    1640                 1645                 1650             


Thr Ser  Ala Thr Thr Asn Leu  Lys Cys Ser Leu Leu  Val Leu Glu 
    1655                 1660                 1665             


Asn Glu  Leu Asn Ala Glu Leu  Gly Leu Ser Gly Ala  Ser Met Lys 
    1670                 1675                 1680             


Leu Thr  Thr Asn Gly Arg Phe  Arg Glu His Asn Ala  Lys Phe Ser 
    1685                 1690                 1695             


Leu Asp  Gly Lys Ala Ala Leu  Thr Glu Leu Ser Leu  Gly Ser Ala 
    1700                 1705                 1710             


Tyr Gln  Ala Met Ile Leu Gly  Val Asp Ser Lys Asn  Ile Phe Asn 
    1715                 1720                 1725             


Phe Lys  Val Ser Gln Glu Gly  Leu Lys Leu Ser Asn  Asp Met Met 
    1730                 1735                 1740             


Gly Ser  Tyr Ala Glu Met Lys  Phe Asp His Thr Asn  Ser Leu Asn 
    1745                 1750                 1755             


Ile Ala  Gly Leu Ser Leu Asp  Phe Ser Ser Lys Leu  Asp Asn Ile 
    1760                 1765                 1770             


Tyr Ser  Ser Asp Lys Phe Tyr  Lys Gln Thr Val Asn  Leu Gln Leu 
    1775                 1780                 1785             


Gln Pro  Tyr Ser Leu Val Thr  Thr Leu Asn Ser Asp  Leu Lys Tyr 
    1790                 1795                 1800             


Asn Ala  Leu Asp Leu Thr Asn  Asn Gly Lys Leu Arg  Leu Glu Pro 
    1805                 1810                 1815             


Leu Lys  Leu His Val Ala Gly  Asn Leu Lys Gly Ala  Tyr Gln Asn 
    1820                 1825                 1830             


Asn Glu  Ile Lys His Ile Tyr  Ala Ile Ser Ser Ala  Ala Leu Ser 
    1835                 1840                 1845             


Ala Ser  Tyr Lys Ala Asp Thr  Val Ala Lys Val Gln  Gly Val Glu 
    1850                 1855                 1860             


Phe Ser  His Arg Leu Asn Thr  Asp Ile Ala Gly Leu  Ala Ser Ala 
    1865                 1870                 1875             


Ile Asp  Met Ser Thr Asn Tyr  Asn Ser Asp Ser Leu  His Phe Ser 
    1880                 1885                 1890             


Asn Val  Phe Arg Ser Val Met  Ala Pro Phe Thr Met  Thr Ile Asp 
    1895                 1900                 1905             


Ala His  Thr Asn Gly Asn Gly  Lys Leu Ala Leu Trp  Gly Glu His 
    1910                 1915                 1920             


Thr Gly  Gln Leu Tyr Ser Lys  Phe Leu Leu Lys Ala  Glu Pro Leu 
    1925                 1930                 1935             


Ala Phe  Thr Phe Ser His Asp  Tyr Lys Gly Ser Thr  Ser His His 
    1940                 1945                 1950             


Leu Val  Ser Arg Lys Ser Ile  Ser Ala Ala Leu Glu  His Lys Val 
    1955                 1960                 1965             


Ser Ala  Leu Leu Thr Pro Ala  Glu Gln Thr Gly Thr  Trp Lys Leu 
    1970                 1975                 1980             


Lys Thr  Gln Phe Asn Asn Asn  Glu Tyr Ser Gln Asp  Leu Asp Ala 
    1985                 1990                 1995             


Tyr Asn  Thr Lys Asp Lys Ile  Gly Val Glu Leu Thr  Gly Arg Thr 
    2000                 2005                 2010             


Leu Ala  Asp Leu Thr Leu Leu  Asp Ser Pro Ile Lys  Val Pro Leu 
    2015                 2020                 2025             


Leu Leu  Ser Glu Pro Ile Asn  Ile Ile Asp Ala Leu  Glu Met Arg 
    2030                 2035                 2040             


Asp Ala  Val Glu Lys Pro Gln  Glu Phe Thr Ile Val  Ala Phe Val 
    2045                 2050                 2055             


Lys Tyr  Asp Lys Asn Gln Asp  Val His Ser Ile Asn  Leu Pro Phe 
    2060                 2065                 2070             


Phe Glu  Thr Leu Gln Glu Tyr  Phe Glu Arg Asn Arg  Gln Thr Ile 
    2075                 2080                 2085             


Ile Val  Val Leu Glu Asn Val  Gln Arg Asn Leu Lys  His Ile Asn 
    2090                 2095                 2100             


Ile Asp  Gln Phe Val Arg Lys  Tyr Arg Ala Ala Leu  Gly Lys Leu 
    2105                 2110                 2115             


Pro Gln  Gln Ala Asn Asp Tyr  Leu Asn Ser Phe Asn  Trp Glu Arg 
    2120                 2125                 2130             


Gln Val  Ser His Ala Lys Glu  Lys Leu Thr Ala Leu  Thr Lys Lys 
    2135                 2140                 2145             


Tyr Arg  Ile Thr Glu Asn Asp  Ile Gln Ile Ala Leu  Asp Asp Ala 
    2150                 2155                 2160             


Lys Ile  Asn Phe Asn Glu Lys  Leu Ser Gln Leu Gln  Thr Tyr Met 
    2165                 2170                 2175             


Ile Gln  Phe Asp Gln Tyr Ile  Lys Asp Ser Tyr Asp  Leu His Asp 
    2180                 2185                 2190             


Leu Lys  Ile Ala Ile Ala Asn  Ile Ile Asp Glu Ile  Ile Glu Lys 
    2195                 2200                 2205             


Leu Lys  Ser Leu Asp Glu His  Tyr His Ile Arg Val  Asn Leu Val 
    2210                 2215                 2220             


Lys Thr  Ile His Asp Leu His  Leu Phe Ile Glu Asn  Ile Asp Phe 
    2225                 2230                 2235             


Asn Lys  Ser Gly Ser Ser Thr  Ala Ser Trp Ile Gln  Asn Val Asp 
    2240                 2245                 2250             


Thr Lys  Tyr Gln Ile Arg Ile  Gln Ile Gln Glu Lys  Leu Gln Gln 
    2255                 2260                 2265             


Leu Lys  Arg His Ile Gln Asn  Ile Asp Ile Gln His  Leu Ala Gly 
    2270                 2275                 2280             


Lys Leu  Lys Gln His Ile Glu  Ala Ile Asp Val Arg  Val Leu Leu 
    2285                 2290                 2295             


Asp Gln  Leu Gly Thr Thr Ile  Ser Phe Glu Arg Ile  Asn Asp Val 
    2300                 2305                 2310             


Leu Glu  His Val Lys His Phe  Val Ile Asn Leu Ile  Gly Asp Phe 
    2315                 2320                 2325             


Glu Val  Ala Glu Lys Ile Asn  Ala Phe Arg Ala Lys  Val His Glu 
    2330                 2335                 2340             


Leu Ile  Glu Arg Tyr Glu Val  Asp Gln Gln Ile Gln  Val Leu Met 
    2345                 2350                 2355             


Asp Lys  Leu Val Glu Leu Ala  His Gln Tyr Lys Leu  Lys Glu Thr 
    2360                 2365                 2370             


Ile Gln  Lys Leu Ser Asn Val  Leu Gln Gln Val Lys  Ile Lys Asp 
    2375                 2380                 2385             


Tyr Phe  Glu Lys Leu Val Gly  Phe Ile Asp Asp Ala  Val Lys Lys 
    2390                 2395                 2400             


Leu Asn  Glu Leu Ser Phe Lys  Thr Phe Ile Glu Asp  Val Asn Lys 
    2405                 2410                 2415             


Phe Leu  Asp Met Leu Ile Lys  Lys Leu Lys Ser Phe  Asp Tyr His 
    2420                 2425                 2430             


Gln Phe  Val Asp Glu Thr Asn  Asp Lys Ile Arg Glu  Val Thr Gln 
    2435                 2440                 2445             


Arg Leu  Asn Gly Glu Ile Gln  Ala Leu Glu Leu Pro  Gln Lys Ala 
    2450                 2455                 2460             


Glu Ala  Leu Lys Leu Phe Leu  Glu Glu Thr Lys Ala  Thr Val Ala 
    2465                 2470                 2475             


Val Tyr  Leu Glu Ser Leu Gln  Asp Thr Lys Ile Thr  Leu Ile Ile 
    2480                 2485                 2490             


Asn Trp  Leu Gln Glu Ala Leu  Ser Ser Ala Ser Leu  Ala His Met 
    2495                 2500                 2505             


Lys Ala  Lys Phe Arg Glu Thr  Leu Glu Asp Thr Arg  Asp Arg Met 
    2510                 2515                 2520             


Tyr Gln  Met Asp Ile Gln Gln  Glu Leu Gln Arg Tyr  Leu Ser Leu 
    2525                 2530                 2535             


Val Gly  Gln Val Tyr Ser Thr  Leu Val Thr Tyr Ile  Ser Asp Trp 
    2540                 2545                 2550             


Trp Thr  Leu Ala Ala Lys Asn  Leu Thr Asp Phe Ala  Glu Gln Tyr 
    2555                 2560                 2565             


Ser Ile  Gln Asp Trp Ala Lys  Arg Met Lys Ala Leu  Val Glu Gln 
    2570                 2575                 2580             


Gly Phe  Thr Val Pro Glu Ile  Lys Thr Ile Leu Gly  Thr Met Pro 
    2585                 2590                 2595             


Ala Phe  Glu Val Ser Leu Gln  Ala Leu Gln Lys Ala  Thr Phe Gln 
    2600                 2605                 2610             


Thr Pro  Asp Phe Ile Val Pro  Leu Thr Asp Leu Arg  Ile Pro Ser 
    2615                 2620                 2625             


Val Gln  Ile Asn Phe Lys Asp  Leu Lys Asn Ile Lys  Ile Pro Ser 
    2630                 2635                 2640             


Arg Phe  Ser Thr Pro Glu Phe  Thr Ile Leu Asn Thr  Phe His Ile 
    2645                 2650                 2655             


Pro Ser  Phe Thr Ile Asp Phe  Val Glu Met Lys Val  Lys Ile Ile 
    2660                 2665                 2670             


Arg Thr  Ile Asp Gln Met Leu  Asn Ser Glu Leu Gln  Trp Pro Val 
    2675                 2680                 2685             


Pro Asp  Ile Tyr Leu Arg Asp  Leu Lys Val Glu Asp  Ile Pro Leu 
    2690                 2695                 2700             


Ala Arg  Ile Thr Leu Pro Asp  Phe Arg Leu Pro Glu  Ile Ala Ile 
    2705                 2710                 2715             


Pro Glu  Phe Ile Ile Pro Thr  Leu Asn Leu Asn Asp  Phe Gln Val 
    2720                 2725                 2730             


Pro Asp  Leu His Ile Pro Glu  Phe Gln Leu Pro His  Ile Ser His 
    2735                 2740                 2745             


Thr Ile  Glu Val Pro Thr Phe  Gly Lys Leu Tyr Ser  Ile Leu Lys 
    2750                 2755                 2760             


Ile Gln  Ser Pro Leu Phe Thr  Leu Asp Ala Asn Ala  Asp Ile Gly 
    2765                 2770                 2775             


Asn Gly  Thr Thr Ser Ala Asn  Glu Ala Gly Ile Ala  Ala Ser Ile 
    2780                 2785                 2790             


Thr Ala  Lys Gly Glu Ser Lys  Leu Glu Val Leu Asn  Phe Asp Phe 
    2795                 2800                 2805             


Gln Ala  Asn Ala Gln Leu Ser  Asn Pro Lys Ile Asn  Pro Leu Ala 
    2810                 2815                 2820             


Leu Lys  Glu Ser Val Lys Phe  Ser Ser Lys Tyr Leu  Arg Thr Glu 
    2825                 2830                 2835             


His Gly  Ser Glu Met Leu Phe  Phe Gly Asn Ala Ile  Glu Gly Lys 
    2840                 2845                 2850             


Ser Asn  Thr Val Ala Ser Leu  His Thr Glu Lys Asn  Thr Leu Glu 
    2855                 2860                 2865             


Leu Ser  Asn Gly Val Ile Val  Lys Ile Asn Asn Gln  Leu Thr Leu 
    2870                 2875                 2880             


Asp Ser  Asn Thr Lys Tyr Phe  His Lys Leu Asn Ile  Pro Lys Leu 
    2885                 2890                 2895             


Asp Phe  Ser Ser Gln Ala Asp  Leu Arg Asn Glu Ile  Lys Thr Leu 
    2900                 2905                 2910             


Leu Lys  Ala Gly His Ile Ala  Trp Thr Ser Ser Gly  Lys Gly Ser 
    2915                 2920                 2925             


Trp Lys  Trp Ala Cys Pro Arg  Phe Ser Asp Glu Gly  Thr His Glu 
    2930                 2935                 2940             


Ser Gln  Ile Ser Phe Thr Ile  Glu Gly Pro Leu Thr  Ser Phe Gly 
    2945                 2950                 2955             


Leu Ser  Asn Lys Ile Asn Ser  Lys His Leu Arg Val  Asn Gln Asn 
    2960                 2965                 2970             


Leu Val  Tyr Glu Ser Gly Ser  Leu Asn Phe Ser Lys  Leu Glu Ile 
    2975                 2980                 2985             


Gln Ser  Gln Val Asp Ser Gln  His Val Gly His Ser  Val Leu Thr 
    2990                 2995                 3000             


Ala Lys  Gly Met Ala Leu Phe  Gly Glu Gly Lys Ala  Glu Phe Thr 
    3005                 3010                 3015             


Gly Arg  His Asp Ala His Leu  Asn Gly Lys Val Ile  Gly Thr Leu 
    3020                 3025                 3030             


Lys Asn  Ser Leu Phe Phe Ser  Ala Gln Pro Phe Glu  Ile Thr Ala 
    3035                 3040                 3045             


Ser Thr  Asn Asn Glu Gly Asn  Leu Lys Val Arg Phe  Pro Leu Arg 
    3050                 3055                 3060             


Leu Thr  Gly Lys Ile Asp Phe  Leu Asn Asn Tyr Ala  Leu Phe Leu 
    3065                 3070                 3075             


Ser Pro  Ser Ala Gln Gln Ala  Ser Trp Gln Val Ser  Ala Arg Phe 
    3080                 3085                 3090             


Asn Gln  Tyr Lys Tyr Asn Gln  Asn Phe Ser Ala Gly  Asn Asn Glu 
    3095                 3100                 3105             


Asn Ile  Met Glu Ala His Val  Gly Ile Asn Gly Glu  Ala Asn Leu 
    3110                 3115                 3120             


Asp Phe  Leu Asn Ile Pro Leu  Thr Ile Pro Glu Met  Arg Leu Pro 
    3125                 3130                 3135             


Tyr Thr  Ile Ile Thr Thr Pro  Pro Leu Lys Asp Phe  Ser Leu Trp 
    3140                 3145                 3150             


Glu Lys  Thr Gly Leu Lys Glu  Phe Leu Lys Thr Thr  Lys Gln Ser 
    3155                 3160                 3165             


Phe Asp  Leu Ser Val Lys Ala  Gln Tyr Lys Lys Asn  Lys His Arg 
    3170                 3175                 3180             


His Ser  Ile Thr Asn Pro Leu  Ala Val Leu Cys Glu  Phe Ile Ser 
    3185                 3190                 3195             


Gln Ser  Ile Lys Ser Phe Asp  Arg His Phe Glu Lys  Asn Arg Asn 
    3200                 3205                 3210             


Asn Ala  Leu Asp Phe Val Thr  Lys Ser Tyr Asn Glu  Thr Lys Ile 
    3215                 3220                 3225             


Lys Phe  Asp Lys Tyr Lys Ala  Glu Lys Ser His Asp  Glu Leu Pro 
    3230                 3235                 3240             


Arg Thr  Phe Gln Ile Pro Gly  Tyr Thr Val Pro Val  Val Asn Val 
    3245                 3250                 3255             


Glu Val  Ser Pro Phe Thr Ile  Glu Met Ser Ala Phe  Gly Tyr Val 
    3260                 3265                 3270             


Phe Pro  Lys Ala Val Ser Met  Pro Ser Phe Ser Ile  Leu Gly Ser 
    3275                 3280                 3285             


Asp Val  Arg Val Pro Ser Tyr  Thr Leu Ile Leu Pro  Ser Leu Glu 
    3290                 3295                 3300             


Leu Pro  Val Leu His Val Pro  Arg Asn Leu Lys Leu  Ser Leu Pro 
    3305                 3310                 3315             


Asp Phe  Lys Glu Leu Cys Thr  Ile Ser His Ile Phe  Ile Pro Ala 
    3320                 3325                 3330             


Met Gly  Asn Ile Thr Tyr Asp  Phe Ser Phe Lys Ser  Ser Val Ile 
    3335                 3340                 3345             


Thr Leu  Asn Thr Asn Ala Glu  Leu Phe Asn Gln Ser  Asp Ile Val 
    3350                 3355                 3360             


Ala His  Leu Leu Ser Ser Ser  Ser Ser Val Ile Asp  Ala Leu Gln 
    3365                 3370                 3375             


Tyr Lys  Leu Glu Gly Thr Thr  Arg Leu Thr Arg Lys  Arg Gly Leu 
    3380                 3385                 3390             


Lys Leu  Ala Thr Ala Leu Ser  Leu Ser Asn Lys Phe  Val Glu Gly 
    3395                 3400                 3405             


Ser His  Asn Ser Thr Val Ser  Leu Thr Thr Lys Asn  Met Glu Val 
    3410                 3415                 3420             


Ser Val  Ala Thr Thr Thr Lys  Ala Gln Ile Pro Ile  Leu Arg Met 
    3425                 3430                 3435             


Asn Phe  Lys Gln Glu Leu Asn  Gly Asn Thr Lys Ser  Lys Pro Thr 
    3440                 3445                 3450             


Val Ser  Ser Ser Met Glu Phe  Lys Tyr Asp Phe Asn  Ser Ser Met 
    3455                 3460                 3465             


Leu Tyr  Ser Thr Ala Lys Gly  Ala Val Asp His Lys  Leu Ser Leu 
    3470                 3475                 3480             


Glu Ser  Leu Thr Ser Tyr Phe  Ser Ile Glu Ser Ser  Thr Lys Gly 
    3485                 3490                 3495             


Asp Val  Lys Gly Ser Val Leu  Ser Arg Glu Tyr Ser  Gly Thr Ile 
    3500                 3505                 3510             


Ala Ser  Glu Ala Asn Thr Tyr  Leu Asn Ser Lys Ser  Thr Arg Ser 
    3515                 3520                 3525             


Ser Val  Lys Leu Gln Gly Thr  Ser Lys Ile Asp Asp  Ile Trp Asn 
    3530                 3535                 3540             


Leu Glu  Val Lys Glu Asn Phe  Ala Gly Glu Ala Thr  Leu Gln Arg 
    3545                 3550                 3555             


Ile Tyr  Ser Leu Trp Glu His  Ser Thr Lys Asn His  Leu Gln Leu 
    3560                 3565                 3570             


Glu Gly  Leu Phe Phe Thr Asn  Gly Glu His Thr Ser  Lys Ala Thr 
    3575                 3580                 3585             


Leu Glu  Leu Ser Pro Trp Gln  Met Ser Ala Leu Val  Gln Val His 
    3590                 3595                 3600             


Ala Ser  Gln Pro Ser Ser Phe  His Asp Phe Pro Asp  Leu Gly Gln 
    3605                 3610                 3615             


Glu Val  Ala Leu Asn Ala Asn  Thr Lys Asn Gln Lys  Ile Arg Trp 
    3620                 3625                 3630             


Lys Asn  Glu Val Arg Ile His  Ser Gly Ser Phe Gln  Ser Gln Val 
    3635                 3640                 3645             


Glu Leu  Ser Asn Asp Gln Glu  Lys Ala His Leu Asp  Ile Ala Gly 
    3650                 3655                 3660             


Ser Leu  Glu Gly His Leu Arg  Phe Leu Lys Asn Ile  Ile Leu Pro 
    3665                 3670                 3675             


Val Tyr  Asp Lys Ser Leu Trp  Asp Phe Leu Lys Leu  Asp Val Thr 
    3680                 3685                 3690             


Thr Ser  Ile Gly Arg Arg Gln  His Leu Arg Val Ser  Thr Ala Phe 
    3695                 3700                 3705             


Val Tyr  Thr Lys Asn Pro Asn  Gly Tyr Ser Phe Ser  Ile Pro Val 
    3710                 3715                 3720             


Lys Val  Leu Ala Asp Lys Phe  Ile Ile Pro Gly Leu  Lys Leu Asn 
    3725                 3730                 3735             


Asp Leu  Asn Ser Val Leu Val  Met Pro Thr Phe His  Val Pro Phe 
    3740                 3745                 3750             


Thr Asp  Leu Gln Val Pro Ser  Cys Lys Leu Asp Phe  Arg Glu Ile 
    3755                 3760                 3765             


Gln Ile  Tyr Lys Lys Leu Arg  Thr Ser Ser Phe Ala  Leu Asn Leu 
    3770                 3775                 3780             


Pro Thr  Leu Pro Glu Val Lys  Phe Pro Glu Val Asp  Val Leu Thr 
    3785                 3790                 3795             


Lys Tyr  Ser Gln Pro Glu Asp  Ser Leu Ile Pro Phe  Phe Glu Ile 
    3800                 3805                 3810             


Thr Val  Pro Glu Ser Gln Leu  Thr Val Ser Gln Phe  Thr Leu Pro 
    3815                 3820                 3825             


Lys Ser  Val Ser Asp Gly Ile  Ala Ala Leu Asp Leu  Asn Ala Val 
    3830                 3835                 3840             


Ala Asn  Lys Ile Ala Asp Phe  Glu Leu Pro Thr Ile  Ile Val Pro 
    3845                 3850                 3855             


Glu Gln  Thr Ile Glu Ile Pro  Ser Ile Lys Phe Ser  Val Pro Ala 
    3860                 3865                 3870             


Gly Ile  Val Ile Pro Ser Phe  Gln Ala Leu Thr Ala  Arg Phe Glu 
    3875                 3880                 3885             


Val Asp  Ser Pro Val Tyr Asn  Ala Thr Trp Ser Ala  Ser Leu Lys 
    3890                 3895                 3900             


Asn Lys  Ala Asp Tyr Val Glu  Thr Val Leu Asp Ser  Thr Cys Ser 
    3905                 3910                 3915             


Ser Thr  Val Gln Phe Leu Glu  Tyr Glu Leu Asn Val  Leu Gly Thr 
    3920                 3925                 3930             


His Lys  Ile Glu Asp Gly Thr  Leu Ala Ser Lys Thr  Lys Gly Thr 
    3935                 3940                 3945             


Phe Ala  His Arg Asp Phe Ser  Ala Glu Tyr Glu Glu  Asp Gly Lys 
    3950                 3955                 3960             


Tyr Glu  Gly Leu Gln Glu Trp  Glu Gly Lys Ala His  Leu Asn Ile 
    3965                 3970                 3975             


Lys Ser  Pro Ala Phe Thr Asp  Leu His Leu Arg Tyr  Gln Lys Asp 
    3980                 3985                 3990             


Lys Lys  Gly Ile Ser Thr Ser  Ala Ala Ser Pro Ala  Val Gly Thr 
    3995                 4000                 4005             


Val Gly  Met Asp Met Asp Glu  Asp Asp Asp Phe Ser  Lys Trp Asn 
    4010                 4015                 4020             


Phe Tyr  Tyr Ser Pro Gln Ser  Ser Pro Asp Lys Lys  Leu Thr Ile 
    4025                 4030                 4035             


Phe Lys  Thr Glu Leu Arg Val  Arg Glu Ser Asp Glu  Glu Thr Gln 
    4040                 4045                 4050             


Ile Lys  Val Asn Trp Glu Glu  Glu Ala Ala Ser Gly  Leu Leu Thr 
    4055                 4060                 4065             


Ser Leu  Lys Asp Asn Val Pro  Lys Ala Thr Gly Val  Leu Tyr Asp 
    4070                 4075                 4080             


Tyr Val  Asn Lys Tyr His Trp  Glu His Thr Gly Leu  Thr Leu Arg 
    4085                 4090                 4095             


Glu Val  Ser Ser Lys Leu Arg  Arg Asn Leu Gln Asn  Asn Ala Glu 
    4100                 4105                 4110             


Trp Val  Tyr Gln Gly Ala Ile  Arg Gln Ile Asp Asp  Ile Asp Val 
    4115                 4120                 4125             


Arg Phe  Gln Lys Ala Ala Ser  Gly Thr Thr Gly Thr  Tyr Gln Glu 
    4130                 4135                 4140             


Trp Lys  Asp Lys Ala Gln Asn  Leu Tyr Gln Glu Leu  Leu Thr Gln 
    4145                 4150                 4155             


Glu Gly  Gln Ala Ser Phe Gln  Gly Leu Lys Asp Asn  Val Phe Asp 
    4160                 4165                 4170             


Gly Leu  Val Arg Val Thr Gln  Glu Phe His Met Lys  Val Lys His 
    4175                 4180                 4185             


Leu Ile  Asp Ser Leu Ile Asp  Phe Leu Asn Phe Pro  Arg Phe Gln 
    4190                 4195                 4200             


Phe Pro  Gly Lys Pro Gly Ile  Tyr Thr Arg Glu Glu  Leu Cys Thr 
    4205                 4210                 4215             


Met Phe  Ile Arg Glu Val Gly  Thr Val Leu Ser Gln  Val Tyr Ser 
    4220                 4225                 4230             


Lys Val  His Asn Gly Ser Glu  Ile Leu Phe Ser Tyr  Phe Gln Asp 
    4235                 4240                 4245             


Leu Val  Ile Thr Leu Pro Phe  Glu Leu Arg Lys His  Lys Leu Ile 
    4250                 4255                 4260             


Asp Val  Ile Ser Met Tyr Arg  Glu Leu Leu Lys Asp  Leu Ser Lys 
    4265                 4270                 4275             


Glu Ala  Gln Glu Val Phe Lys  Ala Ile Gln Ser Leu  Lys Thr Thr 
    4280                 4285                 4290             


Glu Val  Leu Arg Asn Leu Gln  Asp Leu Leu Gln Phe  Ile Phe Gln 
    4295                 4300                 4305             


Leu Ile  Glu Asp Asn Ile Lys  Gln Leu Lys Glu Met  Lys Phe Thr 
    4310                 4315                 4320             


Tyr Leu  Ile Asn Tyr Ile Gln  Asp Glu Ile Asn Thr  Ile Phe Ser 
    4325                 4330                 4335             


Asp Tyr  Ile Pro Tyr Val Phe  Lys Leu Leu Lys Glu  Asn Leu Cys 
    4340                 4345                 4350             


Leu Asn  Leu His Lys Phe Asn  Glu Phe Ile Gln Asn  Glu Leu Gln 
    4355                 4360                 4365             


Glu Ala  Ser Gln Glu Leu Gln  Gln Ile His Gln Tyr  Ile Met Ala 
    4370                 4375                 4380             


Leu Arg  Glu Glu Tyr Phe Asp  Pro Ser Ile Val Gly  Trp Thr Val 
    4385                 4390                 4395             


Lys Tyr  Tyr Glu Leu Glu Glu  Lys Ile Val Ser Leu  Ile Lys Asn 
    4400                 4405                 4410             


Leu Leu  Val Ala Leu Lys Asp  Phe His Ser Glu Tyr  Ile Val Ser 
    4415                 4420                 4425             


Ala Ser  Asn Phe Thr Ser Gln  Leu Ser Ser Gln Val  Glu Gln Phe 
    4430                 4435                 4440             


Leu His  Arg Asn Ile Gln Glu  Tyr Leu Ser Ile Leu  Thr Asp Pro 
    4445                 4450                 4455             


Asp Gly  Lys Gly Lys Glu Lys  Ile Ala Glu Leu Ser  Ala Thr Ala 
    4460                 4465                 4470             


Gln Glu  Ile Ile Lys Ser Gln  Ala Ile Ala Thr Lys  Lys Ile Ile 
    4475                 4480                 4485             


Ser Asp  Tyr His Gln Gln Phe  Arg Tyr Lys Leu Gln  Asp Phe Ser 
    4490                 4495                 4500             


Asp Gln  Leu Ser Asp Tyr Tyr  Glu Lys Phe Ile Ala  Glu Ser Lys 
    4505                 4510                 4515             


Arg Leu  Ile Asp Leu Ser Ile  Gln Asn Tyr His Thr  Phe Leu Ile 
    4520                 4525                 4530             


Tyr Ile  Thr Glu Leu Leu Lys  Lys Leu Gln Ser Thr  Thr Val Met 
    4535                 4540                 4545             


Asn Pro  Tyr Met Lys Leu Ala  Pro Gly Glu Leu Thr  Ile Ile Leu 
    4550                 4555                 4560             


<210>  115
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  115

Met Ala Asp Gln Pro Lys Pro Ile Ser Pro Leu Lys Asn Leu Leu Ala 
1               5                   10                  15      


Gly Gly Phe Gly Gly Val Cys Leu Val Phe Val Gly His Pro Leu Asp 
            20                  25                  30          


Thr Val Lys Val Arg Leu Gln Thr Gln Pro Pro Ser Leu Pro Gly Gln 
        35                  40                  45              


Pro Pro Met Tyr Ser Gly Thr Phe Asp Cys Phe Arg Lys Thr Leu Phe 
    50                  55                  60                  


Arg Glu Gly Ile Thr Gly Leu Tyr Arg Gly Met Ala Ala Pro Ile Ile 
65                  70                  75                  80  


Gly Val Thr Pro Met Phe Ala Val Cys Phe Phe Gly Phe Gly Leu Gly 
                85                  90                  95      


Lys Lys Leu Gln Gln Lys His Pro Glu Asp Val Leu Ser Tyr Pro Gln 
            100                 105                 110         


Leu Phe Ala Ala Gly Met Leu Ser Gly Val Phe Thr Thr Gly Ile Met 
        115                 120                 125             


Thr Pro Gly Glu Arg Ile Lys Cys Leu Leu Gln Ile Gln Ala Ser Ser 
    130                 135                 140                 


Gly Glu Ser Lys Tyr Thr Gly Thr Leu Asp Cys Ala Lys Lys Leu Tyr 
145                 150                 155                 160 


Gln Glu Phe Gly Ile Arg Gly Ile Tyr Lys Gly Thr Val Leu Thr Leu 
                165                 170                 175     


Met Arg Asp Val Pro Ala Ser Gly Met Tyr Phe Met Thr Tyr Glu Trp 
            180                 185                 190         


Leu Lys Asn Ile Phe Thr Pro Glu Gly Lys Arg Val Ser Glu Leu Ser 
        195                 200                 205             


Ala Pro Arg Ile Leu Val Ala Gly Gly Ile Ala Gly Ile Phe Asn Trp 
    210                 215                 220                 


Ala Val Ala Ile Pro Pro Asp Val Leu Lys Ser Arg Phe Gln Thr Ala 
225                 230                 235                 240 


Pro Pro Gly Lys Tyr Pro Asn Gly Phe Arg Asp Val Leu Arg Glu Leu 
                245                 250                 255     


Ile Arg Asp Glu Gly Val Thr Ser Leu Tyr Lys Gly Phe Asn Ala Val 
            260                 265                 270         


Met Ile Arg Ala Phe Pro Ala Asn Ala Ala Cys Phe Leu Gly Phe Glu 
        275                 280                 285             


Val Ala Met Lys Phe Leu Asn Trp Ala Thr Pro Asn Leu 
    290                 295                 300     


<210>  116
<211>  1078
<212>  PRT
<213>  Homo sapiens

<400>  116

Met Ala Phe Tyr Ser Cys Cys Trp Val Leu Leu Ala Leu Thr Trp His 
1               5                   10                  15      


Thr Ser Ala Tyr Gly Pro Asp Gln Arg Ala Gln Lys Lys Gly Asp Ile 
            20                  25                  30          


Ile Leu Gly Gly Leu Phe Pro Ile His Phe Gly Val Ala Ala Lys Asp 
        35                  40                  45              


Gln Asp Leu Lys Ser Arg Pro Glu Ser Val Glu Cys Ile Arg Tyr Asn 
    50                  55                  60                  


Phe Arg Gly Phe Arg Trp Leu Gln Ala Met Ile Phe Ala Ile Glu Glu 
65                  70                  75                  80  


Ile Asn Ser Ser Pro Ala Leu Leu Pro Asn Leu Thr Leu Gly Tyr Arg 
                85                  90                  95      


Ile Phe Asp Thr Cys Asn Thr Val Ser Lys Ala Leu Glu Ala Thr Leu 
            100                 105                 110         


Ser Phe Val Ala Gln Asn Lys Ile Asp Ser Leu Asn Leu Asp Glu Phe 
        115                 120                 125             


Cys Asn Cys Ser Glu His Ile Pro Ser Thr Ile Ala Val Val Gly Ala 
    130                 135                 140                 


Thr Gly Ser Gly Val Ser Thr Ala Val Ala Asn Leu Leu Gly Leu Phe 
145                 150                 155                 160 


Tyr Ile Pro Gln Val Ser Tyr Ala Ser Ser Ser Arg Leu Leu Ser Asn 
                165                 170                 175     


Lys Asn Gln Phe Lys Ser Phe Leu Arg Thr Ile Pro Asn Asp Glu His 
            180                 185                 190         


Gln Ala Thr Ala Met Ala Asp Ile Ile Glu Tyr Phe Arg Trp Asn Trp 
        195                 200                 205             


Val Gly Thr Ile Ala Ala Asp Asp Asp Tyr Gly Arg Pro Gly Ile Glu 
    210                 215                 220                 


Lys Phe Arg Glu Glu Ala Glu Glu Arg Asp Ile Cys Ile Asp Phe Ser 
225                 230                 235                 240 


Glu Leu Ile Ser Gln Tyr Ser Asp Glu Glu Glu Ile Gln His Val Val 
                245                 250                 255     


Glu Val Ile Gln Asn Ser Thr Ala Lys Val Ile Val Val Phe Ser Ser 
            260                 265                 270         


Gly Pro Asp Leu Glu Pro Leu Ile Lys Glu Ile Val Arg Arg Asn Ile 
        275                 280                 285             


Thr Gly Lys Ile Trp Leu Ala Ser Glu Ala Trp Ala Ser Ser Ser Leu 
    290                 295                 300                 


Ile Ala Met Pro Gln Tyr Phe His Val Val Gly Gly Thr Ile Gly Phe 
305                 310                 315                 320 


Ala Leu Lys Ala Gly Gln Ile Pro Gly Phe Arg Glu Phe Leu Lys Lys 
                325                 330                 335     


Val His Pro Arg Lys Ser Val His Asn Gly Phe Ala Lys Glu Phe Trp 
            340                 345                 350         


Glu Glu Thr Phe Asn Cys His Leu Gln Glu Gly Ala Lys Gly Pro Leu 
        355                 360                 365             


Pro Val Asp Thr Phe Leu Arg Gly His Glu Glu Ser Gly Asp Arg Phe 
    370                 375                 380                 


Ser Asn Ser Ser Thr Ala Phe Arg Pro Leu Cys Thr Gly Asp Glu Asn 
385                 390                 395                 400 


Ile Ser Ser Val Glu Thr Pro Tyr Ile Asp Tyr Thr His Leu Arg Ile 
                405                 410                 415     


Ser Tyr Asn Val Tyr Leu Ala Val Tyr Ser Ile Ala His Ala Leu Gln 
            420                 425                 430         


Asp Ile Tyr Thr Cys Leu Pro Gly Arg Gly Leu Phe Thr Asn Gly Ser 
        435                 440                 445             


Cys Ala Asp Ile Lys Lys Val Glu Ala Trp Gln Val Leu Lys His Leu 
    450                 455                 460                 


Arg His Leu Asn Phe Thr Asn Asn Met Gly Glu Gln Val Thr Phe Asp 
465                 470                 475                 480 


Glu Cys Gly Asp Leu Val Gly Asn Tyr Ser Ile Ile Asn Trp His Leu 
                485                 490                 495     


Ser Pro Glu Asp Gly Ser Ile Val Phe Lys Glu Val Gly Tyr Tyr Asn 
            500                 505                 510         


Val Tyr Ala Lys Lys Gly Glu Arg Leu Phe Ile Asn Glu Glu Lys Ile 
        515                 520                 525             


Leu Trp Ser Gly Phe Ser Arg Glu Val Pro Phe Ser Asn Cys Ser Arg 
    530                 535                 540                 


Asp Cys Leu Ala Gly Thr Arg Lys Gly Ile Ile Glu Gly Glu Pro Thr 
545                 550                 555                 560 


Cys Cys Phe Glu Cys Val Glu Cys Pro Asp Gly Glu Tyr Ser Asp Glu 
                565                 570                 575     


Thr Asp Ala Ser Ala Cys Asn Lys Cys Pro Asp Asp Phe Trp Ser Asn 
            580                 585                 590         


Glu Asn His Thr Ser Cys Ile Ala Lys Glu Ile Glu Phe Leu Ser Trp 
        595                 600                 605             


Thr Glu Pro Phe Gly Ile Ala Leu Thr Leu Phe Ala Val Leu Gly Ile 
    610                 615                 620                 


Phe Leu Thr Ala Phe Val Leu Gly Val Phe Ile Lys Phe Arg Asn Thr 
625                 630                 635                 640 


Pro Ile Val Lys Ala Thr Asn Arg Glu Leu Ser Tyr Leu Leu Leu Phe 
                645                 650                 655     


Ser Leu Leu Cys Cys Phe Ser Ser Ser Leu Phe Phe Ile Gly Glu Pro 
            660                 665                 670         


Gln Asp Trp Thr Cys Arg Leu Arg Gln Pro Ala Phe Gly Ile Ser Phe 
        675                 680                 685             


Val Leu Cys Ile Ser Cys Ile Leu Val Lys Thr Asn Arg Val Leu Leu 
    690                 695                 700                 


Val Phe Glu Ala Lys Ile Pro Thr Ser Phe His Arg Lys Trp Trp Gly 
705                 710                 715                 720 


Leu Asn Leu Gln Phe Leu Leu Val Phe Leu Cys Thr Phe Met Gln Ile 
                725                 730                 735     


Val Ile Cys Val Ile Trp Leu Tyr Thr Ala Pro Pro Ser Ser Tyr Arg 
            740                 745                 750         


Asn Gln Glu Leu Glu Asp Glu Ile Ile Phe Ile Thr Cys His Glu Gly 
        755                 760                 765             


Ser Leu Met Ala Leu Gly Phe Leu Ile Gly Tyr Thr Cys Leu Leu Ala 
    770                 775                 780                 


Ala Ile Cys Phe Phe Phe Ala Phe Lys Ser Arg Lys Leu Pro Glu Asn 
785                 790                 795                 800 


Phe Asn Glu Ala Lys Phe Ile Thr Phe Ser Met Leu Ile Phe Phe Ile 
                805                 810                 815     


Val Trp Ile Ser Phe Ile Pro Ala Tyr Ala Ser Thr Tyr Gly Lys Phe 
            820                 825                 830         


Val Ser Ala Val Glu Val Ile Ala Ile Leu Ala Ala Ser Phe Gly Leu 
        835                 840                 845             


Leu Ala Cys Ile Phe Phe Asn Lys Ile Tyr Ile Ile Leu Phe Lys Pro 
    850                 855                 860                 


Ser Arg Asn Thr Ile Glu Glu Val Arg Cys Ser Thr Ala Ala His Ala 
865                 870                 875                 880 


Phe Lys Val Ala Ala Arg Ala Thr Leu Arg Arg Ser Asn Val Ser Arg 
                885                 890                 895     


Lys Arg Ser Ser Ser Leu Gly Gly Ser Thr Gly Ser Thr Pro Ser Ser 
            900                 905                 910         


Ser Ile Ser Ser Lys Ser Asn Ser Glu Asp Pro Phe Pro Gln Pro Glu 
        915                 920                 925             


Arg Gln Lys Gln Gln Gln Pro Leu Ala Leu Thr Gln Gln Glu Gln Gln 
    930                 935                 940                 


Gln Gln Pro Leu Thr Leu Pro Gln Gln Gln Arg Ser Gln Gln Gln Pro 
945                 950                 955                 960 


Arg Cys Lys Gln Lys Val Ile Phe Gly Ser Gly Thr Val Thr Phe Ser 
                965                 970                 975     


Leu Ser Phe Asp Glu Pro Gln Lys Asn Ala Met Ala His Arg Asn Ser 
            980                 985                 990         


Thr His Gln Asn Ser Leu Glu Ala  Gln Lys Ser Ser Asp  Thr Leu Thr 
        995                 1000                 1005             


Arg His  Gln Pro Leu Leu Pro  Leu Gln Cys Gly Glu  Thr Asp Leu 
    1010                 1015                 1020             


Asp Leu  Thr Val Gln Glu Thr  Gly Leu Gln Gly Pro  Val Gly Gly 
    1025                 1030                 1035             


Asp Gln  Arg Pro Glu Val Glu  Asp Pro Glu Glu Leu  Ser Pro Ala 
    1040                 1045                 1050             


Leu Val  Val Ser Ser Ser Gln  Ser Phe Val Ile Ser  Gly Gly Gly 
    1055                 1060                 1065             


Ser Thr  Val Thr Glu Asn Val  Val Asn Ser 
    1070                 1075             


<210>  117
<211>  1545
<212>  PRT
<213>  Homo sapiens

<400>  117

Met Leu Glu Lys Phe Cys Asn Ser Thr Phe Trp Asn Ser Ser Phe Leu 
1               5                   10                  15      


Asp Ser Pro Glu Ala Asp Leu Pro Leu Cys Phe Glu Gln Thr Val Leu 
            20                  25                  30          


Val Trp Ile Pro Leu Gly Phe Leu Trp Leu Leu Ala Pro Trp Gln Leu 
        35                  40                  45              


Leu His Val Tyr Lys Ser Arg Thr Lys Arg Ser Ser Thr Thr Lys Leu 
    50                  55                  60                  


Tyr Leu Ala Lys Gln Val Phe Val Gly Phe Leu Leu Ile Leu Ala Ala 
65                  70                  75                  80  


Ile Glu Leu Ala Leu Val Leu Thr Glu Asp Ser Gly Gln Ala Thr Val 
                85                  90                  95      


Pro Ala Val Arg Tyr Thr Asn Pro Ser Leu Tyr Leu Gly Thr Trp Leu 
            100                 105                 110         


Leu Val Leu Leu Ile Gln Tyr Ser Arg Gln Trp Cys Val Gln Lys Asn 
        115                 120                 125             


Ser Trp Phe Leu Ser Leu Phe Trp Ile Leu Ser Ile Leu Cys Gly Thr 
    130                 135                 140                 


Phe Gln Phe Gln Thr Leu Ile Arg Thr Leu Leu Gln Gly Asp Asn Ser 
145                 150                 155                 160 


Asn Leu Ala Tyr Ser Cys Leu Phe Phe Ile Ser Tyr Gly Phe Gln Ile 
                165                 170                 175     


Leu Ile Leu Ile Phe Ser Ala Phe Ser Glu Asn Asn Glu Ser Ser Asn 
            180                 185                 190         


Asn Pro Ser Ser Ile Ala Ser Phe Leu Ser Ser Ile Thr Tyr Ser Trp 
        195                 200                 205             


Tyr Asp Ser Ile Ile Leu Lys Gly Tyr Lys Arg Pro Leu Thr Leu Glu 
    210                 215                 220                 


Asp Val Trp Glu Val Asp Glu Glu Met Lys Thr Lys Thr Leu Val Ser 
225                 230                 235                 240 


Lys Phe Glu Thr His Met Lys Arg Glu Leu Gln Lys Ala Arg Arg Ala 
                245                 250                 255     


Leu Gln Arg Arg Gln Glu Lys Ser Ser Gln Gln Asn Ser Gly Ala Arg 
            260                 265                 270         


Leu Pro Gly Leu Asn Lys Asn Gln Ser Gln Ser Gln Asp Ala Leu Val 
        275                 280                 285             


Leu Glu Asp Val Glu Lys Lys Lys Lys Lys Ser Gly Thr Lys Lys Asp 
    290                 295                 300                 


Val Pro Lys Ser Trp Leu Met Lys Ala Leu Phe Lys Thr Phe Tyr Met 
305                 310                 315                 320 


Val Leu Leu Lys Ser Phe Leu Leu Lys Leu Val Asn Asp Ile Phe Thr 
                325                 330                 335     


Phe Val Ser Pro Gln Leu Leu Lys Leu Leu Ile Ser Phe Ala Ser Asp 
            340                 345                 350         


Arg Asp Thr Tyr Leu Trp Ile Gly Tyr Leu Cys Ala Ile Leu Leu Phe 
        355                 360                 365             


Thr Ala Ala Leu Ile Gln Ser Phe Cys Leu Gln Cys Tyr Phe Gln Leu 
    370                 375                 380                 


Cys Phe Lys Leu Gly Val Lys Val Arg Thr Ala Ile Met Ala Ser Val 
385                 390                 395                 400 


Tyr Lys Lys Ala Leu Thr Leu Ser Asn Leu Ala Arg Lys Glu Tyr Thr 
                405                 410                 415     


Val Gly Glu Thr Val Asn Leu Met Ser Val Asp Ala Gln Lys Leu Met 
            420                 425                 430         


Asp Val Thr Asn Phe Met His Met Leu Trp Ser Ser Val Leu Gln Ile 
        435                 440                 445             


Val Leu Ser Ile Phe Phe Leu Trp Arg Glu Leu Gly Pro Ser Val Leu 
    450                 455                 460                 


Ala Gly Val Gly Val Met Val Leu Val Ile Pro Ile Asn Ala Ile Leu 
465                 470                 475                 480 


Ser Thr Lys Ser Lys Thr Ile Gln Val Lys Asn Met Lys Asn Lys Asp 
                485                 490                 495     


Lys Arg Leu Lys Ile Met Asn Glu Ile Leu Ser Gly Ile Lys Ile Leu 
            500                 505                 510         


Lys Tyr Phe Ala Trp Glu Pro Ser Phe Arg Asp Gln Val Gln Asn Leu 
        515                 520                 525             


Arg Lys Lys Glu Leu Lys Asn Leu Leu Ala Phe Ser Gln Leu Gln Cys 
    530                 535                 540                 


Val Val Ile Phe Val Phe Gln Leu Thr Pro Val Leu Val Ser Val Val 
545                 550                 555                 560 


Thr Phe Ser Val Tyr Val Leu Val Asp Ser Asn Asn Ile Leu Asp Ala 
                565                 570                 575     


Gln Lys Ala Phe Thr Ser Ile Thr Leu Phe Asn Ile Leu Arg Phe Pro 
            580                 585                 590         


Leu Ser Met Leu Pro Met Met Ile Ser Ser Met Leu Gln Ala Ser Val 
        595                 600                 605             


Ser Thr Glu Arg Leu Glu Lys Tyr Leu Gly Gly Asp Asp Leu Asp Thr 
    610                 615                 620                 


Ser Ala Ile Arg His Asp Cys Asn Phe Asp Lys Ala Met Gln Phe Ser 
625                 630                 635                 640 


Glu Ala Ser Phe Thr Trp Glu His Asp Ser Glu Ala Thr Val Arg Asp 
                645                 650                 655     


Val Asn Leu Asp Ile Met Ala Gly Gln Leu Val Ala Val Ile Gly Pro 
            660                 665                 670         


Val Gly Ser Gly Lys Ser Ser Leu Ile Ser Ala Met Leu Gly Glu Met 
        675                 680                 685             


Glu Asn Val His Gly His Ile Thr Ile Lys Gly Thr Thr Ala Tyr Val 
    690                 695                 700                 


Pro Gln Gln Ser Trp Ile Gln Asn Gly Thr Ile Lys Asp Asn Ile Leu 
705                 710                 715                 720 


Phe Gly Thr Glu Phe Asn Glu Lys Arg Tyr Gln Gln Val Leu Glu Ala 
                725                 730                 735     


Cys Ala Leu Leu Pro Asp Leu Glu Met Leu Pro Gly Gly Asp Leu Ala 
            740                 745                 750         


Glu Ile Gly Glu Lys Gly Ile Asn Leu Ser Gly Gly Gln Lys Gln Arg 
        755                 760                 765             


Ile Ser Leu Ala Arg Ala Thr Tyr Gln Asn Leu Asp Ile Tyr Leu Leu 
    770                 775                 780                 


Asp Asp Pro Leu Ser Ala Val Asp Ala His Val Gly Lys His Ile Phe 
785                 790                 795                 800 


Asn Lys Val Leu Gly Pro Asn Gly Leu Leu Lys Gly Lys Thr Arg Leu 
                805                 810                 815     


Leu Val Thr His Ser Met His Phe Leu Pro Gln Val Asp Glu Ile Val 
            820                 825                 830         


Val Leu Gly Asn Gly Thr Ile Val Glu Lys Gly Ser Tyr Ser Ala Leu 
        835                 840                 845             


Leu Ala Lys Lys Gly Glu Phe Ala Lys Asn Leu Lys Thr Phe Leu Arg 
    850                 855                 860                 


His Thr Gly Pro Glu Glu Glu Ala Thr Val His Asp Gly Ser Glu Glu 
865                 870                 875                 880 


Glu Asp Asp Asp Tyr Gly Leu Ile Ser Ser Val Glu Glu Ile Pro Glu 
                885                 890                 895     


Asp Ala Ala Ser Ile Thr Met Arg Arg Glu Asn Ser Phe Arg Arg Thr 
            900                 905                 910         


Leu Ser Arg Ser Ser Arg Ser Asn Gly Arg His Leu Lys Ser Leu Arg 
        915                 920                 925             


Asn Ser Leu Lys Thr Arg Asn Val Asn Ser Leu Lys Glu Asp Glu Glu 
    930                 935                 940                 


Leu Val Lys Gly Gln Lys Leu Ile Lys Lys Glu Phe Ile Glu Thr Gly 
945                 950                 955                 960 


Lys Val Lys Phe Ser Ile Tyr Leu Glu Tyr Leu Gln Ala Ile Gly Leu 
                965                 970                 975     


Phe Ser Ile Phe Phe Ile Ile Leu Ala Phe Val Met Asn Ser Val Ala 
            980                 985                 990         


Phe Ile Gly Ser Asn Leu Trp Leu  Ser Ala Trp Thr Ser  Asp Ser Lys 
        995                 1000                 1005             


Ile Phe  Asn Ser Thr Asp Tyr  Pro Ala Ser Gln Arg  Asp Met Arg 
    1010                 1015                 1020             


Val Gly  Val Tyr Gly Ala Leu  Gly Leu Ala Gln Gly  Ile Phe Val 
    1025                 1030                 1035             


Phe Ile  Ala His Phe Trp Ser  Ala Phe Gly Phe Val  His Ala Ser 
    1040                 1045                 1050             


Asn Ile  Leu His Lys Gln Leu  Leu Asn Asn Ile Leu  Arg Ala Pro 
    1055                 1060                 1065             


Met Arg  Phe Phe Asp Thr Thr  Pro Thr Gly Arg Ile  Val Asn Arg 
    1070                 1075                 1080             


Phe Ala  Gly Asp Ile Ser Thr  Val Asp Asp Thr Leu  Pro Gln Ser 
    1085                 1090                 1095             


Leu Arg  Ser Trp Ile Thr Cys  Phe Leu Gly Ile Ile  Ser Thr Leu 
    1100                 1105                 1110             


Val Met  Ile Cys Met Ala Thr  Pro Val Phe Thr Ile  Ile Val Ile 
    1115                 1120                 1125             


Pro Leu  Gly Ile Ile Tyr Val  Ser Val Gln Met Phe  Tyr Val Ser 
    1130                 1135                 1140             


Thr Ser  Arg Gln Leu Arg Arg  Leu Asp Ser Val Thr  Arg Ser Pro 
    1145                 1150                 1155             


Ile Tyr  Ser His Phe Ser Glu  Thr Val Ser Gly Leu  Pro Val Ile 
    1160                 1165                 1170             


Arg Ala  Phe Glu His Gln Gln  Arg Phe Leu Lys His  Asn Glu Val 
    1175                 1180                 1185             


Arg Ile  Asp Thr Asn Gln Lys  Cys Val Phe Ser Trp  Ile Thr Ser 
    1190                 1195                 1200             


Asn Arg  Trp Leu Ala Ile Arg  Leu Glu Leu Val Gly  Asn Leu Thr 
    1205                 1210                 1215             


Val Phe  Phe Ser Ala Leu Met  Met Val Ile Tyr Arg  Asp Thr Leu 
    1220                 1225                 1230             


Ser Gly  Asp Thr Val Gly Phe  Val Leu Ser Asn Ala  Leu Asn Ile 
    1235                 1240                 1245             


Thr Gln  Thr Leu Asn Trp Leu  Val Arg Met Thr Ser  Glu Ile Glu 
    1250                 1255                 1260             


Thr Asn  Ile Val Ala Val Glu  Arg Ile Thr Glu Tyr  Thr Lys Val 
    1265                 1270                 1275             


Glu Asn  Glu Ala Pro Trp Val  Thr Asp Lys Arg Pro  Pro Pro Asp 
    1280                 1285                 1290             


Trp Pro  Ser Lys Gly Lys Ile  Gln Phe Asn Asn Tyr  Gln Val Arg 
    1295                 1300                 1305             


Tyr Arg  Pro Glu Leu Asp Leu  Val Leu Arg Gly Ile  Thr Cys Asp 
    1310                 1315                 1320             


Ile Gly  Ser Met Glu Lys Ile  Gly Val Val Gly Arg  Thr Gly Ala 
    1325                 1330                 1335             


Gly Lys  Ser Ser Leu Thr Asn  Cys Leu Phe Arg Ile  Leu Glu Ala 
    1340                 1345                 1350             


Ala Gly  Gly Gln Ile Ile Ile  Asp Gly Val Asp Ile  Ala Ser Ile 
    1355                 1360                 1365             


Gly Leu  His Asp Leu Arg Glu  Lys Leu Thr Ile Ile  Pro Gln Asp 
    1370                 1375                 1380             


Pro Ile  Leu Phe Ser Gly Ser  Leu Arg Met Asn Leu  Asp Pro Phe 
    1385                 1390                 1395             


Asn Asn  Tyr Ser Asp Glu Glu  Ile Trp Lys Ala Leu  Glu Leu Ala 
    1400                 1405                 1410             


His Leu  Lys Ser Phe Val Ala  Ser Leu Gln Leu Gly  Leu Ser His 
    1415                 1420                 1425             


Glu Val  Thr Glu Ala Gly Gly  Asn Leu Ser Ile Gly  Gln Arg Gln 
    1430                 1435                 1440             


Leu Leu  Cys Leu Gly Arg Ala  Leu Leu Arg Lys Ser  Lys Ile Leu 
    1445                 1450                 1455             


Val Leu  Asp Glu Ala Thr Ala  Ala Val Asp Leu Glu  Thr Asp Asn 
    1460                 1465                 1470             


Leu Ile  Gln Thr Thr Ile Gln  Asn Glu Phe Ala His  Cys Thr Val 
    1475                 1480                 1485             


Ile Thr  Ile Ala His Arg Leu  His Thr Ile Met Asp  Ser Asp Lys 
    1490                 1495                 1500             


Val Met  Val Leu Asp Asn Gly  Lys Ile Ile Glu Cys  Gly Ser Pro 
    1505                 1510                 1515             


Glu Glu  Leu Leu Gln Ile Pro  Gly Pro Phe Tyr Phe  Met Ala Lys 
    1520                 1525                 1530             


Glu Ala  Gly Ile Glu Asn Val  Asn Ser Thr Lys Phe  
    1535                 1540                 1545 


<210>  118
<211>  570
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Gly Asn Trp Ala Val Asn Glu Gly Leu Ser Ile Phe Val Ile Leu 
1               5                   10                  15      


Val Trp Leu Gly Leu Asn Val Phe Leu Phe Val Trp Tyr Tyr Arg Val 
            20                  25                  30          


Tyr Asp Ile Pro Pro Lys Phe Phe Tyr Thr Arg Lys Leu Leu Gly Ser 
        35                  40                  45              


Ala Leu Ala Leu Ala Arg Ala Pro Ala Ala Cys Leu Asn Phe Asn Cys 
    50                  55                  60                  


Met Leu Ile Leu Leu Pro Val Cys Arg Asn Leu Leu Ser Phe Leu Arg 
65                  70                  75                  80  


Gly Ser Ser Ala Cys Cys Ser Thr Arg Val Arg Arg Gln Leu Asp Arg 
                85                  90                  95      


Asn Leu Thr Phe His Lys Met Val Ala Trp Met Ile Ala Leu His Ser 
            100                 105                 110         


Ala Ile His Thr Ile Ala His Leu Phe Asn Val Glu Trp Cys Val Asn 
        115                 120                 125             


Ala Arg Val Asn Asn Ser Asp Pro Tyr Ser Val Ala Leu Ser Glu Leu 
    130                 135                 140                 


Gly Asp Arg Gln Asn Glu Ser Tyr Leu Asn Phe Ala Arg Lys Arg Ile 
145                 150                 155                 160 


Lys Asn Pro Glu Gly Gly Leu Tyr Leu Ala Val Thr Leu Leu Ala Gly 
                165                 170                 175     


Ile Thr Gly Val Val Ile Thr Leu Cys Leu Ile Leu Ile Ile Thr Ser 
            180                 185                 190         


Ser Thr Lys Thr Ile Arg Arg Ser Tyr Phe Glu Val Phe Trp Tyr Thr 
        195                 200                 205             


His His Leu Phe Val Ile Phe Phe Ile Gly Leu Ala Ile His Gly Ala 
    210                 215                 220                 


Glu Arg Ile Val Arg Gly Gln Thr Ala Glu Ser Leu Ala Val His Asn 
225                 230                 235                 240 


Ile Thr Val Cys Glu Gln Lys Ile Ser Glu Trp Gly Lys Ile Lys Glu 
                245                 250                 255     


Cys Pro Ile Pro Gln Phe Ala Gly Asn Pro Pro Met Thr Trp Lys Trp 
            260                 265                 270         


Ile Val Gly Pro Met Phe Leu Tyr Leu Cys Glu Arg Leu Val Arg Phe 
        275                 280                 285             


Trp Arg Ser Gln Gln Lys Val Val Ile Thr Lys Val Val Thr His Pro 
    290                 295                 300                 


Phe Lys Thr Ile Glu Leu Gln Met Lys Lys Lys Gly Phe Lys Met Glu 
305                 310                 315                 320 


Val Gly Gln Tyr Ile Phe Val Lys Cys Pro Lys Val Ser Lys Leu Glu 
                325                 330                 335     


Trp His Pro Phe Thr Leu Thr Ser Ala Pro Glu Glu Asp Phe Phe Ser 
            340                 345                 350         


Ile His Ile Arg Ile Val Gly Asp Trp Thr Glu Gly Leu Phe Asn Ala 
        355                 360                 365             


Cys Gly Cys Asp Lys Gln Glu Phe Gln Asp Ala Trp Lys Leu Pro Lys 
    370                 375                 380                 


Ile Ala Val Asp Gly Pro Phe Gly Thr Ala Ser Glu Asp Val Phe Ser 
385                 390                 395                 400 


Tyr Glu Val Val Met Leu Val Gly Ala Gly Ile Gly Val Thr Pro Phe 
                405                 410                 415     


Ala Ser Ile Leu Lys Ser Val Trp Tyr Lys Tyr Cys Asn Asn Ala Thr 
            420                 425                 430         


Asn Leu Lys Leu Lys Lys Ile Tyr Phe Tyr Trp Leu Cys Arg Asp Thr 
        435                 440                 445             


His Ala Phe Glu Trp Phe Ala Asp Leu Leu Gln Leu Leu Glu Ser Gln 
    450                 455                 460                 


Met Gln Glu Arg Asn Asn Ala Gly Phe Leu Ser Tyr Asn Ile Tyr Leu 
465                 470                 475                 480 


Thr Gly Trp Asp Glu Ser Gln Ala Asn His Phe Ala Val His His Asp 
                485                 490                 495     


Glu Glu Lys Asp Val Ile Thr Gly Leu Lys Gln Lys Thr Leu Tyr Gly 
            500                 505                 510         


Arg Pro Asn Trp Asp Asn Glu Phe Lys Thr Ile Ala Ser Gln His Pro 
        515                 520                 525             


Asn Thr Arg Ile Gly Val Phe Leu Cys Gly Pro Glu Ala Leu Ala Glu 
    530                 535                 540                 


Thr Leu Ser Lys Gln Ser Ile Ser Asn Ser Glu Ser Gly Pro Arg Gly 
545                 550                 555                 560 


Val His Phe Ile Phe Asn Lys Glu Asn Phe 
                565                 570 


<210>  119
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Ala Asn Ser Ala Ser Pro Glu Gln Asn Gln Asn His Cys Ser Ala 
1               5                   10                  15      


Ile Asn Asn Ser Ile Pro Leu Met Gln Gly Asn Leu Pro Thr Leu Thr 
            20                  25                  30          


Leu Ser Gly Lys Ile Arg Val Thr Val Thr Phe Phe Leu Phe Leu Leu 
        35                  40                  45              


Ser Ala Thr Phe Asn Ala Ser Phe Leu Leu Lys Leu Gln Lys Trp Thr 
    50                  55                  60                  


Gln Lys Lys Glu Lys Gly Lys Lys Leu Ser Arg Met Lys Leu Leu Leu 
65                  70                  75                  80  


Lys His Leu Thr Leu Ala Asn Leu Leu Glu Thr Leu Ile Val Met Pro 
                85                  90                  95      


Leu Asp Gly Met Trp Asn Ile Thr Val Gln Trp Tyr Ala Gly Glu Leu 
            100                 105                 110         


Leu Cys Lys Val Leu Ser Tyr Leu Lys Leu Phe Ser Met Tyr Ala Pro 
        115                 120                 125             


Ala Phe Met Met Val Val Ile Ser Leu Asp Arg Ser Leu Ala Ile Thr 
    130                 135                 140                 


Arg Pro Leu Ala Leu Lys Ser Asn Ser Lys Val Gly Gln Ser Met Val 
145                 150                 155                 160 


Gly Leu Ala Trp Ile Leu Ser Ser Val Phe Ala Gly Pro Gln Leu Tyr 
                165                 170                 175     


Ile Phe Arg Met Ile His Leu Ala Asp Ser Ser Gly Gln Thr Lys Val 
            180                 185                 190         


Phe Ser Gln Cys Val Thr His Cys Ser Phe Ser Gln Trp Trp His Gln 
        195                 200                 205             


Ala Phe Tyr Asn Phe Phe Thr Phe Ser Cys Leu Phe Ile Ile Pro Leu 
    210                 215                 220                 


Phe Ile Met Leu Ile Cys Asn Ala Lys Ile Ile Phe Thr Leu Thr Arg 
225                 230                 235                 240 


Val Leu His Gln Asp Pro His Glu Leu Gln Leu Asn Gln Ser Lys Asn 
                245                 250                 255     


Asn Ile Pro Arg Ala Arg Leu Lys Thr Leu Lys Met Thr Val Ala Phe 
            260                 265                 270         


Ala Thr Ser Phe Thr Val Cys Trp Thr Pro Tyr Tyr Val Leu Gly Ile 
        275                 280                 285             


Trp Tyr Trp Phe Asp Pro Glu Met Leu Asn Arg Leu Ser Asp Pro Val 
    290                 295                 300                 


Asn His Phe Phe Phe Leu Phe Ala Phe Leu Asn Pro Cys Phe Asp Pro 
305                 310                 315                 320 


Leu Ile Tyr Gly Tyr Phe Ser Leu 
                325             


<210>  120
<211>  727
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Ala Phe Gln Lys Ala Val Lys Gly Thr Ile Leu Val Gly Gly Gly 
1               5                   10                  15      


Ala Leu Ala Thr Val Leu Gly Leu Ser Gln Phe Ala His Tyr Arg Arg 
            20                  25                  30          


Lys Gln Met Asn Leu Ala Tyr Val Lys Ala Ala Asp Cys Ile Ser Glu 
        35                  40                  45              


Pro Val Asn Arg Glu Pro Pro Ser Arg Glu Ala Gln Leu Leu Thr Leu 
    50                  55                  60                  


Gln Asn Thr Ser Glu Phe Asp Ile Leu Val Ile Gly Gly Gly Ala Thr 
65                  70                  75                  80  


Gly Ser Gly Cys Ala Leu Asp Ala Val Thr Arg Gly Leu Lys Thr Ala 
                85                  90                  95      


Leu Val Glu Arg Asp Asp Phe Ser Ser Gly Thr Ser Ser Arg Ser Thr 
            100                 105                 110         


Lys Leu Ile His Gly Gly Val Arg Tyr Leu Gln Lys Ala Ile Met Lys 
        115                 120                 125             


Leu Asp Ile Glu Gln Tyr Arg Met Val Lys Glu Ala Leu His Glu Arg 
    130                 135                 140                 


Ala Asn Leu Leu Glu Ile Ala Pro His Leu Ser Ala Pro Leu Pro Ile 
145                 150                 155                 160 


Met Leu Pro Val Tyr Lys Trp Trp Gln Leu Pro Tyr Tyr Trp Val Gly 
                165                 170                 175     


Ile Lys Leu Tyr Asp Leu Val Ala Gly Ser Asn Cys Leu Lys Ser Ser 
            180                 185                 190         


Tyr Val Leu Ser Lys Ser Arg Ala Leu Glu His Phe Pro Met Leu Gln 
        195                 200                 205             


Lys Asp Lys Leu Val Gly Ala Ile Val Tyr Tyr Asp Gly Gln His Asn 
    210                 215                 220                 


Asp Ala Arg Met Asn Leu Ala Ile Ala Leu Thr Ala Ala Arg Tyr Gly 
225                 230                 235                 240 


Ala Ala Thr Ala Asn Tyr Met Glu Val Val Ser Leu Leu Lys Lys Thr 
                245                 250                 255     


Asp Pro Gln Thr Gly Lys Val Arg Val Ser Gly Ala Arg Cys Lys Asp 
            260                 265                 270         


Val Leu Thr Gly Gln Glu Phe Asp Val Arg Ala Lys Cys Val Ile Asn 
        275                 280                 285             


Ala Thr Gly Pro Phe Thr Asp Ser Val Arg Lys Met Asp Asp Lys Asp 
    290                 295                 300                 


Ala Ala Ala Ile Cys Gln Pro Ser Ala Gly Val His Ile Val Met Pro 
305                 310                 315                 320 


Gly Tyr Tyr Ser Pro Glu Ser Met Gly Leu Leu Asp Pro Ala Thr Ser 
                325                 330                 335     


Asp Gly Arg Val Ile Phe Phe Leu Pro Trp Gln Lys Met Thr Ile Ala 
            340                 345                 350         


Gly Thr Thr Asp Thr Pro Thr Asp Val Thr His His Pro Ile Pro Ser 
        355                 360                 365             


Glu Glu Asp Ile Asn Phe Ile Leu Asn Glu Val Arg Asn Tyr Leu Ser 
    370                 375                 380                 


Cys Asp Val Glu Val Arg Arg Gly Asp Val Leu Ala Ala Trp Ser Gly 
385                 390                 395                 400 


Ile Arg Pro Leu Val Thr Asp Pro Lys Ser Ala Asp Thr Gln Ser Ile 
                405                 410                 415     


Ser Arg Asn His Val Val Asp Ile Ser Glu Ser Gly Leu Ile Thr Ile 
            420                 425                 430         


Ala Gly Gly Lys Trp Thr Thr Tyr Arg Ser Met Ala Glu Asp Thr Ile 
        435                 440                 445             


Asn Ala Ala Val Lys Thr His Asn Leu Lys Ala Gly Pro Ser Arg Thr 
    450                 455                 460                 


Val Gly Leu Phe Leu Gln Gly Gly Lys Asp Trp Ser Pro Thr Leu Tyr 
465                 470                 475                 480 


Ile Arg Leu Val Gln Asp Tyr Gly Leu Glu Ser Glu Val Ala Gln His 
                485                 490                 495     


Leu Ala Ala Thr Tyr Gly Asp Lys Ala Phe Glu Val Ala Lys Met Ala 
            500                 505                 510         


Ser Val Thr Gly Lys Arg Trp Pro Ile Val Gly Val Arg Leu Val Ser 
        515                 520                 525             


Glu Phe Pro Tyr Ile Glu Ala Glu Val Lys Tyr Gly Ile Lys Glu Tyr 
    530                 535                 540                 


Ala Cys Thr Ala Val Asp Met Ile Ser Arg Arg Thr Arg Leu Ala Phe 
545                 550                 555                 560 


Leu Asn Val Gln Ala Ala Glu Glu Ala Leu Pro Arg Ile Val Glu Leu 
                565                 570                 575     


Met Gly Arg Glu Leu Asn Trp Asp Asp Tyr Lys Lys Gln Glu Gln Leu 
            580                 585                 590         


Glu Thr Ala Arg Lys Phe Leu Tyr Tyr Glu Met Gly Tyr Lys Ser Arg 
        595                 600                 605             


Ser Glu Gln Leu Thr Asp Arg Ser Glu Ile Ser Leu Leu Pro Ser Asp 
    610                 615                 620                 


Ile Asp Arg Tyr Lys Lys Arg Phe His Lys Phe Asp Ala Asp Gln Lys 
625                 630                 635                 640 


Gly Phe Ile Thr Ile Val Asp Val Gln Arg Val Leu Glu Ser Ile Asn 
                645                 650                 655     


Val Gln Met Asp Glu Asn Thr Leu His Glu Ile Leu Asn Glu Val Asp 
            660                 665                 670         


Leu Asn Lys Asn Gly Gln Val Glu Leu Asn Glu Phe Leu Gln Leu Met 
        675                 680                 685             


Ser Ala Ile Gln Lys Gly Arg Val Ser Gly Ser Arg Leu Ala Ile Leu 
    690                 695                 700                 


Met Lys Thr Ala Glu Glu Asn Leu Asp Arg Arg Val Pro Ile Pro Val 
705                 710                 715                 720 


Asp Arg Ser Cys Gly Gly Leu 
                725         


<210>  121
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  121

Met Gly Pro Arg Ala Arg Pro Ala Leu Leu Leu Leu Met Leu Leu Gln 
1               5                   10                  15      


Thr Ala Val Leu Gln Gly Arg Leu Leu Arg Ser His Ser Leu His Tyr 
            20                  25                  30          


Leu Phe Met Gly Ala Ser Glu Gln Asp Leu Gly Leu Ser Leu Phe Glu 
        35                  40                  45              


Ala Leu Gly Tyr Val Asp Asp Gln Leu Phe Val Phe Tyr Asp His Glu 
    50                  55                  60                  


Ser Arg Arg Val Glu Pro Arg Thr Pro Trp Val Ser Ser Arg Ile Ser 
65                  70                  75                  80  


Ser Gln Met Trp Leu Gln Leu Ser Gln Ser Leu Lys Gly Trp Asp His 
                85                  90                  95      


Met Phe Thr Val Asp Phe Trp Thr Ile Met Glu Asn His Asn His Ser 
            100                 105                 110         


Lys Glu Ser His Thr Leu Gln Val Ile Leu Gly Cys Glu Met Gln Glu 
        115                 120                 125             


Asp Asn Ser Thr Glu Gly Tyr Trp Lys Tyr Gly Tyr Asp Gly Gln Asp 
    130                 135                 140                 


His Leu Glu Phe Cys Pro Asp Thr Leu Asp Trp Arg Ala Ala Glu Pro 
145                 150                 155                 160 


Arg Ala Trp Pro Thr Lys Leu Glu Trp Glu Arg His Lys Ile Arg Ala 
                165                 170                 175     


Arg Gln Asn Arg Ala Tyr Leu Glu Arg Asp Cys Pro Ala Gln Leu Gln 
            180                 185                 190         


Gln Leu Leu Glu Leu Gly Arg Gly Val Leu Asp Gln Gln Val Pro Pro 
        195                 200                 205             


Leu Val Lys Val Thr His His Val Thr Ser Ser Val Thr Thr Leu Arg 
    210                 215                 220                 


Cys Arg Ala Leu Asn Tyr Tyr Pro Gln Asn Ile Thr Met Lys Trp Leu 
225                 230                 235                 240 


Lys Asp Lys Gln Pro Met Asp Ala Lys Glu Phe Glu Pro Lys Asp Val 
                245                 250                 255     


Leu Pro Asn Gly Asp Gly Thr Tyr Gln Gly Trp Ile Thr Leu Ala Val 
            260                 265                 270         


Pro Pro Gly Glu Glu Gln Arg Tyr Thr Cys Gln Val Glu His Pro Gly 
        275                 280                 285             


Leu Asp Gln Pro Leu Ile Val Ile Trp Glu Pro Ser Pro Ser Gly Thr 
    290                 295                 300                 


Leu Val Ile Gly Val Ile Ser Gly Ile Ala Val Phe Val Val Ile Leu 
305                 310                 315                 320 


Phe Ile Gly Ile Leu Phe Ile Ile Leu Arg Lys Arg Gln Gly Ser Arg 
                325                 330                 335     


Gly Ala Met Gly His Tyr Val Leu Ala Glu Arg Glu 
            340                 345             


<210>  122
<211>  825
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Gly Trp Leu Cys Ser Gly Leu Leu Phe Pro Val Ser Cys Leu Val 
1               5                   10                  15      


Leu Leu Gln Val Ala Ser Ser Gly Asn Met Lys Val Leu Gln Glu Pro 
            20                  25                  30          


Thr Cys Val Ser Asp Tyr Met Ser Ile Ser Thr Cys Glu Trp Lys Met 
        35                  40                  45              


Asn Gly Pro Thr Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr Gln Leu 
    50                  55                  60                  


Val Phe Leu Leu Ser Glu Ala His Thr Cys Ile Pro Glu Asn Asn Gly 
65                  70                  75                  80  


Gly Ala Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser Ala 
                85                  90                  95      


Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Lys 
            100                 105                 110         


Gly Ser Phe Lys Pro Ser Glu His Val Lys Pro Arg Ala Pro Gly Asn 
        115                 120                 125             


Leu Thr Val His Thr Asn Val Ser Asp Thr Leu Leu Leu Thr Trp Ser 
    130                 135                 140                 


Asn Pro Tyr Pro Pro Asp Asn Tyr Leu Tyr Asn His Leu Thr Tyr Ala 
145                 150                 155                 160 


Val Asn Ile Trp Ser Glu Asn Asp Pro Ala Asp Phe Arg Ile Tyr Asn 
                165                 170                 175     


Val Thr Tyr Leu Glu Pro Ser Leu Arg Ile Ala Ala Ser Thr Leu Lys 
            180                 185                 190         


Ser Gly Ile Ser Tyr Arg Ala Arg Val Arg Ala Trp Ala Gln Cys Tyr 
        195                 200                 205             


Asn Thr Thr Trp Ser Glu Trp Ser Pro Ser Thr Lys Trp His Asn Ser 
    210                 215                 220                 


Tyr Arg Glu Pro Phe Glu Gln His Leu Leu Leu Gly Val Ser Val Ser 
225                 230                 235                 240 


Cys Ile Val Ile Leu Ala Val Cys Leu Leu Cys Tyr Val Ser Ile Thr 
                245                 250                 255     


Lys Ile Lys Lys Glu Trp Trp Asp Gln Ile Pro Asn Pro Ala Arg Ser 
            260                 265                 270         


Arg Leu Val Ala Ile Ile Ile Gln Asp Ala Gln Gly Ser Gln Trp Glu 
        275                 280                 285             


Lys Arg Ser Arg Gly Gln Glu Pro Ala Lys Cys Pro His Trp Lys Asn 
    290                 295                 300                 


Cys Leu Thr Lys Leu Leu Pro Cys Phe Leu Glu His Asn Met Lys Arg 
305                 310                 315                 320 


Asp Glu Asp Pro His Lys Ala Ala Lys Glu Met Pro Phe Gln Gly Ser 
                325                 330                 335     


Gly Lys Ser Ala Trp Cys Pro Val Glu Ile Ser Lys Thr Val Leu Trp 
            340                 345                 350         


Pro Glu Ser Ile Ser Val Val Arg Cys Val Glu Leu Phe Glu Ala Pro 
        355                 360                 365             


Val Glu Cys Glu Glu Glu Glu Glu Val Glu Glu Glu Lys Gly Ser Phe 
    370                 375                 380                 


Cys Ala Ser Pro Glu Ser Ser Arg Asp Asp Phe Gln Glu Gly Arg Glu 
385                 390                 395                 400 


Gly Ile Val Ala Arg Leu Thr Glu Ser Leu Phe Leu Asp Leu Leu Gly 
                405                 410                 415     


Glu Glu Asn Gly Gly Phe Cys Gln Gln Asp Met Gly Glu Ser Cys Leu 
            420                 425                 430         


Leu Pro Pro Ser Gly Ser Thr Ser Ala His Met Pro Trp Asp Glu Phe 
        435                 440                 445             


Pro Ser Ala Gly Pro Lys Glu Ala Pro Pro Trp Gly Lys Glu Gln Pro 
    450                 455                 460                 


Leu His Leu Glu Pro Ser Pro Pro Ala Ser Pro Thr Gln Ser Pro Asp 
465                 470                 475                 480 


Asn Leu Thr Cys Thr Glu Thr Pro Leu Val Ile Ala Gly Asn Pro Ala 
                485                 490                 495     


Tyr Arg Ser Phe Ser Asn Ser Leu Ser Gln Ser Pro Cys Pro Arg Glu 
            500                 505                 510         


Leu Gly Pro Asp Pro Leu Leu Ala Arg His Leu Glu Glu Val Glu Pro 
        515                 520                 525             


Glu Met Pro Cys Val Pro Gln Leu Ser Glu Pro Thr Thr Val Pro Gln 
    530                 535                 540                 


Pro Glu Pro Glu Thr Trp Glu Gln Ile Leu Arg Arg Asn Val Leu Gln 
545                 550                 555                 560 


His Gly Ala Ala Ala Ala Pro Val Ser Ala Pro Thr Ser Gly Tyr Gln 
                565                 570                 575     


Glu Phe Val His Ala Val Glu Gln Gly Gly Thr Gln Ala Ser Ala Val 
            580                 585                 590         


Val Gly Leu Gly Pro Pro Gly Glu Ala Gly Tyr Lys Ala Phe Ser Ser 
        595                 600                 605             


Leu Leu Ala Ser Ser Ala Val Ser Pro Glu Lys Cys Gly Phe Gly Ala 
    610                 615                 620                 


Ser Ser Gly Glu Glu Gly Tyr Lys Pro Phe Gln Asp Leu Ile Pro Gly 
625                 630                 635                 640 


Cys Pro Gly Asp Pro Ala Pro Val Pro Val Pro Leu Phe Thr Phe Gly 
                645                 650                 655     


Leu Asp Arg Glu Pro Pro Arg Ser Pro Gln Ser Ser His Leu Pro Ser 
            660                 665                 670         


Ser Ser Pro Glu His Leu Gly Leu Glu Pro Gly Glu Lys Val Glu Asp 
        675                 680                 685             


Met Pro Lys Pro Pro Leu Pro Gln Glu Gln Ala Thr Asp Pro Leu Val 
    690                 695                 700                 


Asp Ser Leu Gly Ser Gly Ile Val Tyr Ser Ala Leu Thr Cys His Leu 
705                 710                 715                 720 


Cys Gly His Leu Lys Gln Cys His Gly Gln Glu Asp Gly Gly Gln Thr 
                725                 730                 735     


Pro Val Met Ala Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg Ser 
            740                 745                 750         


Ser Pro Pro Thr Thr Pro Leu Arg Ala Pro Asp Pro Ser Pro Gly Gly 
        755                 760                 765             


Val Pro Leu Glu Ala Ser Leu Cys Pro Ala Ser Leu Ala Pro Ser Gly 
    770                 775                 780                 


Ile Ser Glu Lys Ser Lys Ser Ser Ser Ser Phe His Pro Ala Pro Gly 
785                 790                 795                 800 


Asn Ala Gln Ser Ser Ser Gln Thr Pro Lys Ile Val Asn Phe Val Ser 
                805                 810                 815     


Val Gly Pro Thr Tyr Met Arg Val Ser 
            820                 825 


<210>  123
<211>  1039
<212>  PRT
<213>  Homo sapiens

<400>  123

Met Ala Arg Ala Leu Cys Pro Leu Gln Ala Leu Trp Leu Leu Glu Trp 
1               5                   10                  15      


Val Leu Leu Leu Leu Gly Pro Cys Ala Ala Pro Pro Ala Trp Ala Leu 
            20                  25                  30          


Asn Leu Asp Pro Val Gln Leu Thr Phe Tyr Ala Gly Pro Asn Gly Ser 
        35                  40                  45              


Gln Phe Gly Phe Ser Leu Asp Phe His Lys Asp Ser His Gly Arg Val 
    50                  55                  60                  


Ala Ile Val Val Gly Ala Pro Arg Thr Leu Gly Pro Ser Gln Glu Glu 
65                  70                  75                  80  


Thr Gly Gly Val Phe Leu Cys Pro Trp Arg Ala Glu Gly Gly Gln Cys 
                85                  90                  95      


Pro Ser Leu Leu Phe Asp Leu Arg Asp Glu Thr Arg Asn Val Gly Ser 
            100                 105                 110         


Gln Thr Leu Gln Thr Phe Lys Ala Arg Gln Gly Leu Gly Ala Ser Val 
        115                 120                 125             


Val Ser Trp Ser Asp Val Ile Val Ala Cys Ala Pro Trp Gln His Trp 
    130                 135                 140                 


Asn Val Leu Glu Lys Thr Glu Glu Ala Glu Lys Thr Pro Val Gly Ser 
145                 150                 155                 160 


Cys Phe Leu Ala Gln Pro Glu Ser Gly Arg Arg Ala Glu Tyr Ser Pro 
                165                 170                 175     


Cys Arg Gly Asn Thr Leu Ser Arg Ile Tyr Val Glu Asn Asp Phe Ser 
            180                 185                 190         


Trp Asp Lys Arg Tyr Cys Glu Ala Gly Phe Ser Ser Val Val Thr Gln 
        195                 200                 205             


Ala Gly Glu Leu Val Leu Gly Ala Pro Gly Gly Tyr Tyr Phe Leu Gly 
    210                 215                 220                 


Leu Leu Ala Gln Ala Pro Val Ala Asp Ile Phe Ser Ser Tyr Arg Pro 
225                 230                 235                 240 


Gly Ile Leu Leu Trp His Val Ser Ser Gln Ser Leu Ser Phe Asp Ser 
                245                 250                 255     


Ser Asn Pro Glu Tyr Phe Asp Gly Tyr Trp Gly Tyr Ser Val Ala Val 
            260                 265                 270         


Gly Glu Phe Asp Gly Asp Leu Asn Thr Thr Glu Tyr Val Val Gly Ala 
        275                 280                 285             


Pro Thr Trp Ser Trp Thr Leu Gly Ala Val Glu Ile Leu Asp Ser Tyr 
    290                 295                 300                 


Tyr Gln Arg Leu His Arg Leu Arg Gly Glu Gln Met Ala Ser Tyr Phe 
305                 310                 315                 320 


Gly His Ser Val Ala Val Thr Asp Val Asn Gly Asp Gly Arg His Asp 
                325                 330                 335     


Leu Leu Val Gly Ala Pro Leu Tyr Met Glu Ser Arg Ala Asp Arg Lys 
            340                 345                 350         


Leu Ala Glu Val Gly Arg Val Tyr Leu Phe Leu Gln Pro Arg Gly Pro 
        355                 360                 365             


His Ala Leu Gly Ala Pro Ser Leu Leu Leu Thr Gly Thr Gln Leu Tyr 
    370                 375                 380                 


Gly Arg Phe Gly Ser Ala Ile Ala Pro Leu Gly Asp Leu Asp Arg Asp 
385                 390                 395                 400 


Gly Tyr Asn Asp Ile Ala Val Ala Ala Pro Tyr Gly Gly Pro Ser Gly 
                405                 410                 415     


Arg Gly Gln Val Leu Val Phe Leu Gly Gln Ser Glu Gly Leu Arg Ser 
            420                 425                 430         


Arg Pro Ser Gln Val Leu Asp Ser Pro Phe Pro Thr Gly Ser Ala Phe 
        435                 440                 445             


Gly Phe Ser Leu Arg Gly Ala Val Asp Ile Asp Asp Asn Gly Tyr Pro 
    450                 455                 460                 


Asp Leu Ile Val Gly Ala Tyr Gly Ala Asn Gln Val Ala Val Tyr Arg 
465                 470                 475                 480 


Ala Gln Pro Val Val Lys Ala Ser Val Gln Leu Leu Val Gln Asp Ser 
                485                 490                 495     


Leu Asn Pro Ala Val Lys Ser Cys Val Leu Pro Gln Thr Lys Thr Pro 
            500                 505                 510         


Val Ser Cys Phe Asn Ile Gln Met Cys Val Gly Ala Thr Gly His Asn 
        515                 520                 525             


Ile Pro Gln Lys Leu Ser Leu Asn Ala Glu Leu Gln Leu Asp Arg Gln 
    530                 535                 540                 


Lys Pro Arg Gln Gly Arg Arg Val Leu Leu Leu Gly Ser Gln Gln Ala 
545                 550                 555                 560 


Gly Thr Thr Leu Asn Leu Asp Leu Gly Gly Lys His Ser Pro Ile Cys 
                565                 570                 575     


His Thr Thr Met Ala Phe Leu Arg Asp Glu Ala Asp Phe Arg Asp Lys 
            580                 585                 590         


Leu Ser Pro Ile Val Leu Ser Leu Asn Val Ser Leu Pro Pro Thr Glu 
        595                 600                 605             


Ala Gly Met Ala Pro Ala Val Val Leu His Gly Asp Thr His Val Gln 
    610                 615                 620                 


Glu Gln Thr Arg Ile Val Leu Asp Cys Gly Glu Asp Asp Val Cys Val 
625                 630                 635                 640 


Pro Gln Leu Gln Leu Thr Ala Ser Val Thr Gly Ser Pro Leu Leu Val 
                645                 650                 655     


Gly Ala Asp Asn Val Leu Glu Leu Gln Met Asp Ala Ala Asn Glu Gly 
            660                 665                 670         


Glu Gly Ala Tyr Glu Ala Glu Leu Ala Val His Leu Pro Gln Gly Ala 
        675                 680                 685             


His Tyr Met Arg Ala Leu Ser Asn Val Glu Gly Phe Glu Arg Leu Ile 
    690                 695                 700                 


Cys Asn Gln Lys Lys Glu Asn Glu Thr Arg Val Val Leu Cys Glu Leu 
705                 710                 715                 720 


Gly Asn Pro Met Lys Lys Asn Ala Gln Ile Gly Ile Ala Met Leu Val 
                725                 730                 735     


Ser Val Gly Asn Leu Glu Glu Ala Gly Glu Ser Val Ser Phe Gln Leu 
            740                 745                 750         


Gln Ile Arg Ser Lys Asn Ser Gln Asn Pro Asn Ser Lys Ile Val Leu 
        755                 760                 765             


Leu Asp Val Pro Val Arg Ala Glu Ala Gln Val Glu Leu Arg Gly Asn 
    770                 775                 780                 


Ser Phe Pro Ala Ser Leu Val Val Ala Ala Glu Glu Gly Glu Arg Glu 
785                 790                 795                 800 


Gln Asn Ser Leu Asp Ser Trp Gly Pro Lys Val Glu His Thr Tyr Glu 
                805                 810                 815     


Leu His Asn Asn Gly Pro Gly Thr Val Asn Gly Leu His Leu Ser Ile 
            820                 825                 830         


His Leu Pro Gly Gln Ser Gln Pro Ser Asp Leu Leu Tyr Ile Leu Asp 
        835                 840                 845             


Ile Gln Pro Gln Gly Gly Leu Gln Cys Phe Pro Gln Pro Pro Val Asn 
    850                 855                 860                 


Pro Leu Lys Val Asp Trp Gly Leu Pro Ile Pro Ser Pro Ser Pro Ile 
865                 870                 875                 880 


His Pro Ala His His Lys Arg Asp Arg Arg Gln Ile Phe Leu Pro Glu 
                885                 890                 895     


Pro Glu Gln Pro Ser Arg Leu Gln Asp Pro Val Leu Val Ser Cys Asp 
            900                 905                 910         


Ser Ala Pro Cys Thr Val Val Gln Cys Asp Leu Gln Glu Met Ala Arg 
        915                 920                 925             


Gly Gln Arg Ala Met Val Thr Val Leu Ala Phe Leu Trp Leu Pro Ser 
    930                 935                 940                 


Leu Tyr Gln Arg Pro Leu Asp Gln Phe Val Leu Gln Ser His Ala Trp 
945                 950                 955                 960 


Phe Asn Val Ser Ser Leu Pro Tyr Ala Val Pro Pro Leu Ser Leu Pro 
                965                 970                 975     


Arg Gly Glu Ala Gln Val Trp Thr Gln Leu Leu Arg Ala Leu Glu Glu 
            980                 985                 990         


Arg Ala Ile Pro Ile Trp Trp Val  Leu Val Gly Val Leu  Gly Gly Leu 
        995                 1000                 1005             


Leu Leu  Leu Thr Ile Leu Val  Leu Ala Met Trp Lys  Val Gly Phe 
    1010                 1015                 1020             


Phe Lys  Arg Asn Arg Pro Pro  Leu Glu Glu Asp Asp  Glu Glu Gly 
    1025                 1030                 1035             


Glu 
    


<210>  124
<211>  732
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Glu Gly Gly Asp Gln Ser Glu Glu Glu Pro Arg Glu Arg Ser Gln 
1               5                   10                  15      


Ala Gly Gly Met Gly Thr Leu Trp Ser Gln Glu Ser Thr Pro Glu Glu 
            20                  25                  30          


Arg Leu Pro Val Glu Gly Ser Arg Pro Trp Ala Val Ala Arg Arg Val 
        35                  40                  45              


Leu Thr Ala Ile Leu Ile Leu Gly Leu Leu Leu Cys Phe Ser Val Leu 
    50                  55                  60                  


Leu Phe Tyr Asn Phe Gln Asn Cys Gly Pro Arg Pro Cys Glu Thr Ser 
65                  70                  75                  80  


Val Cys Leu Asp Leu Arg Asp His Tyr Leu Ala Ser Gly Asn Thr Ser 
                85                  90                  95      


Val Ala Pro Cys Thr Asp Phe Phe Ser Phe Ala Cys Gly Arg Ala Lys 
            100                 105                 110         


Glu Thr Asn Asn Ser Phe Gln Glu Leu Ala Thr Lys Asn Lys Asn Arg 
        115                 120                 125             


Leu Arg Arg Ile Leu Glu Val Gln Asn Ser Trp His Pro Gly Ser Gly 
    130                 135                 140                 


Glu Glu Lys Ala Phe Gln Phe Tyr Asn Ser Cys Met Asp Thr Leu Ala 
145                 150                 155                 160 


Ile Glu Ala Ala Gly Thr Gly Pro Leu Arg Gln Val Ile Glu Glu Leu 
                165                 170                 175     


Gly Gly Trp Arg Ile Ser Gly Lys Trp Thr Ser Leu Asn Phe Asn Arg 
            180                 185                 190         


Thr Leu Arg Leu Leu Met Ser Gln Tyr Gly His Phe Pro Phe Phe Arg 
        195                 200                 205             


Ala Tyr Leu Gly Pro His Pro Ala Ser Pro His Thr Pro Val Ile Gln 
    210                 215                 220                 


Ile Asp Gln Pro Glu Phe Asp Val Pro Leu Lys Gln Asp Gln Glu Gln 
225                 230                 235                 240 


Lys Ile Tyr Ala Gln Ile Phe Arg Glu Tyr Leu Thr Tyr Leu Asn Gln 
                245                 250                 255     


Leu Gly Thr Leu Leu Gly Gly Asp Pro Ser Lys Val Gln Glu His Ser 
            260                 265                 270         


Ser Leu Ser Ile Ser Ile Thr Ser Arg Leu Phe Gln Phe Leu Arg Pro 
        275                 280                 285             


Leu Glu Gln Arg Arg Ala Gln Gly Lys Leu Phe Gln Met Val Thr Ile 
    290                 295                 300                 


Asp Gln Leu Lys Glu Met Ala Pro Ala Ile Asp Trp Leu Ser Cys Leu 
305                 310                 315                 320 


Gln Ala Thr Phe Thr Pro Met Ser Leu Ser Pro Ser Gln Ser Leu Val 
                325                 330                 335     


Val His Asp Val Glu Tyr Leu Lys Asn Met Ser Gln Leu Val Glu Glu 
            340                 345                 350         


Met Leu Leu Lys Gln Arg Asp Phe Leu Gln Ser His Met Ile Leu Gly 
        355                 360                 365             


Leu Val Val Thr Leu Ser Pro Ala Leu Asp Ser Gln Phe Gln Glu Ala 
    370                 375                 380                 


Arg Arg Lys Leu Ser Gln Lys Leu Arg Glu Leu Thr Glu Gln Pro Pro 
385                 390                 395                 400 


Met Pro Ala Arg Pro Arg Trp Met Lys Cys Val Glu Glu Thr Gly Thr 
                405                 410                 415     


Phe Phe Glu Pro Thr Leu Ala Ala Leu Phe Val Arg Glu Ala Phe Gly 
            420                 425                 430         


Pro Ser Thr Arg Ser Ala Ala Met Lys Leu Phe Thr Ala Ile Arg Asp 
        435                 440                 445             


Ala Leu Ile Thr Arg Leu Arg Asn Leu Pro Trp Met Asn Glu Glu Thr 
    450                 455                 460                 


Gln Asn Met Ala Gln Asp Lys Val Ala Gln Leu Gln Val Glu Met Gly 
465                 470                 475                 480 


Ala Ser Glu Trp Ala Leu Lys Pro Glu Leu Ala Arg Gln Glu Tyr Asn 
                485                 490                 495     


Asp Ile Gln Leu Gly Ser Ser Phe Leu Gln Ser Val Leu Ser Cys Val 
            500                 505                 510         


Arg Ser Leu Arg Ala Arg Ile Val Gln Ser Phe Leu Gln Pro His Pro 
        515                 520                 525             


Gln His Arg Trp Lys Val Ser Pro Trp Asp Val Asn Ala Tyr Tyr Ser 
    530                 535                 540                 


Val Ser Asp His Val Val Val Phe Pro Ala Gly Leu Leu Gln Pro Pro 
545                 550                 555                 560 


Phe Phe His Pro Gly Tyr Pro Arg Ala Val Asn Phe Gly Ala Ala Gly 
                565                 570                 575     


Ser Ile Met Ala His Glu Leu Leu His Ile Phe Tyr Gln Leu Leu Leu 
            580                 585                 590         


Pro Gly Gly Cys Leu Ala Cys Asp Asn His Ala Leu Gln Glu Ala His 
        595                 600                 605             


Leu Cys Leu Lys Arg His Tyr Ala Ala Phe Pro Leu Pro Ser Arg Thr 
    610                 615                 620                 


Ser Phe Asn Asp Ser Leu Thr Phe Leu Glu Asn Ala Ala Asp Val Gly 
625                 630                 635                 640 


Gly Leu Ala Ile Ala Leu Gln Ala Tyr Ser Lys Arg Leu Leu Arg His 
                645                 650                 655     


His Gly Glu Thr Val Leu Pro Ser Leu Asp Leu Ser Pro Gln Gln Ile 
            660                 665                 670         


Phe Phe Arg Ser Tyr Ala Gln Val Met Cys Arg Lys Pro Ser Pro Gln 
        675                 680                 685             


Asp Ser His Asp Thr His Ser Pro Pro His Leu Arg Val His Gly Pro 
    690                 695                 700                 


Leu Ser Ser Thr Pro Ala Phe Ala Arg Tyr Phe Arg Cys Ala Arg Gly 
705                 710                 715                 720 


Ala Leu Leu Asn Pro Ser Ser Arg Cys Gln Leu Trp 
                725                 730         


<210>  125
<211>  590
<212>  PRT
<213>  Homo sapiens

<400>  125

Met Ser Arg Gln Ser Ser Val Ser Phe Arg Ser Gly Gly Ser Arg Ser 
1               5                   10                  15      


Phe Ser Thr Ala Ser Ala Ile Thr Pro Ser Val Ser Arg Thr Ser Phe 
            20                  25                  30          


Thr Ser Val Ser Arg Ser Gly Gly Gly Gly Gly Gly Gly Phe Gly Arg 
        35                  40                  45              


Val Ser Leu Ala Gly Ala Cys Gly Val Gly Gly Tyr Gly Ser Arg Ser 
    50                  55                  60                  


Leu Tyr Asn Leu Gly Gly Ser Lys Arg Ile Ser Ile Ser Thr Ser Gly 
65                  70                  75                  80  


Gly Ser Phe Arg Asn Arg Phe Gly Ala Gly Ala Gly Gly Gly Tyr Gly 
                85                  90                  95      


Phe Gly Gly Gly Ala Gly Ser Gly Phe Gly Phe Gly Gly Gly Ala Gly 
            100                 105                 110         


Gly Gly Phe Gly Leu Gly Gly Gly Ala Gly Phe Gly Gly Gly Phe Gly 
        115                 120                 125             


Gly Pro Gly Phe Pro Val Cys Pro Pro Gly Gly Ile Gln Glu Val Thr 
    130                 135                 140                 


Val Asn Gln Ser Leu Leu Thr Pro Leu Asn Leu Gln Ile Asp Pro Ser 
145                 150                 155                 160 


Ile Gln Arg Val Arg Thr Glu Glu Arg Glu Gln Ile Lys Thr Leu Asn 
                165                 170                 175     


Asn Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln 
            180                 185                 190         


Asn Lys Val Leu Asp Thr Lys Trp Thr Leu Leu Gln Glu Gln Gly Thr 
        195                 200                 205             


Lys Thr Val Arg Gln Asn Leu Glu Pro Leu Phe Glu Gln Tyr Ile Asn 
    210                 215                 220                 


Asn Leu Arg Arg Gln Leu Asp Ser Ile Val Gly Glu Arg Gly Arg Leu 
225                 230                 235                 240 


Asp Ser Glu Leu Arg Asn Met Gln Asp Leu Val Glu Asp Phe Lys Asn 
                245                 250                 255     


Lys Tyr Glu Asp Glu Ile Asn Lys Arg Thr Thr Ala Glu Asn Glu Phe 
            260                 265                 270         


Val Met Leu Lys Lys Asp Val Asp Ala Ala Tyr Met Asn Lys Val Glu 
        275                 280                 285             


Leu Glu Ala Lys Val Asp Ala Leu Met Asp Glu Ile Asn Phe Met Lys 
    290                 295                 300                 


Met Phe Phe Asp Ala Glu Leu Ser Gln Met Gln Thr His Val Ser Asp 
305                 310                 315                 320 


Thr Ser Val Val Leu Ser Met Asp Asn Asn Arg Asn Leu Asp Leu Asp 
                325                 330                 335     


Ser Ile Ile Ala Glu Val Lys Ala Gln Tyr Glu Glu Ile Ala Asn Arg 
            340                 345                 350         


Ser Arg Thr Glu Ala Glu Ser Trp Tyr Gln Thr Lys Tyr Glu Glu Leu 
        355                 360                 365             


Gln Gln Thr Ala Gly Arg His Gly Asp Asp Leu Arg Asn Thr Lys His 
    370                 375                 380                 


Glu Ile Ser Glu Met Asn Arg Met Ile Gln Arg Leu Arg Ala Glu Ile 
385                 390                 395                 400 


Asp Asn Val Lys Lys Gln Cys Ala Asn Leu Gln Asn Ala Ile Ala Asp 
                405                 410                 415     


Ala Glu Gln Arg Gly Glu Leu Ala Leu Lys Asp Ala Arg Asn Lys Leu 
            420                 425                 430         


Ala Glu Leu Glu Glu Ala Leu Gln Lys Ala Lys Gln Asp Met Ala Arg 
        435                 440                 445             


Leu Leu Arg Glu Tyr Gln Glu Leu Met Asn Thr Lys Leu Ala Leu Asp 
    450                 455                 460                 


Val Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg 
465                 470                 475                 480 


Leu Ser Gly Glu Gly Val Gly Pro Val Asn Ile Ser Val Val Thr Ser 
                485                 490                 495     


Ser Val Ser Ser Gly Tyr Gly Ser Gly Ser Gly Tyr Gly Gly Gly Leu 
            500                 505                 510         


Gly Gly Gly Leu Gly Gly Gly Leu Gly Gly Gly Leu Ala Gly Gly Ser 
        515                 520                 525             


Ser Gly Ser Tyr Tyr Ser Ser Ser Ser Gly Gly Val Gly Leu Gly Gly 
    530                 535                 540                 


Gly Leu Ser Val Gly Gly Ser Gly Phe Ser Ala Ser Ser Gly Arg Gly 
545                 550                 555                 560 


Leu Gly Val Gly Phe Gly Ser Gly Gly Gly Ser Ser Ser Ser Val Lys 
                565                 570                 575     


Phe Val Ser Thr Thr Ser Ser Ser Arg Lys Ser Phe Lys Ser 
            580                 585                 590 


<210>  126
<211>  1257
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Val Val Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro 
1               5                   10                  15      


Cys Leu Leu Ile Gln Ile Pro Glu Glu Tyr Glu Gly His His Val Met 
            20                  25                  30          


Glu Pro Pro Val Ile Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe 
        35                  40                  45              


Pro Thr Asp Asp Ile Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu 
    50                  55                  60                  


Val Gln Phe Arg Trp Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu 
65                  70                  75                  80  


Glu Leu Gly Val Thr Val Tyr Gln Ser Pro His Ser Gly Ser Phe Thr 
                85                  90                  95      


Ile Thr Gly Asn Asn Ser Asn Phe Ala Gln Arg Phe Gln Gly Ile Tyr 
            100                 105                 110         


Arg Cys Phe Ala Ser Asn Lys Leu Gly Thr Ala Met Ser His Glu Ile 
        115                 120                 125             


Arg Leu Met Ala Glu Gly Ala Pro Lys Trp Pro Lys Glu Thr Val Lys 
    130                 135                 140                 


Pro Val Glu Val Glu Glu Gly Glu Ser Val Val Leu Pro Cys Asn Pro 
145                 150                 155                 160 


Pro Pro Ser Ala Glu Pro Leu Arg Ile Tyr Trp Met Asn Ser Lys Ile 
                165                 170                 175     


Leu His Ile Lys Gln Asp Glu Arg Val Thr Met Gly Gln Asn Gly Asn 
            180                 185                 190         


Leu Tyr Phe Ala Asn Val Leu Thr Ser Asp Asn His Ser Asp Tyr Ile 
        195                 200                 205             


Cys His Ala His Phe Pro Gly Thr Arg Thr Ile Ile Gln Lys Glu Pro 
    210                 215                 220                 


Ile Asp Leu Arg Val Lys Ala Thr Asn Ser Met Ile Asp Arg Lys Pro 
225                 230                 235                 240 


Arg Leu Leu Phe Pro Thr Asn Ser Ser Ser His Leu Val Ala Leu Gln 
                245                 250                 255     


Gly Gln Pro Leu Val Leu Glu Cys Ile Ala Glu Gly Phe Pro Thr Pro 
            260                 265                 270         


Thr Ile Lys Trp Leu Arg Pro Ser Gly Pro Met Pro Ala Asp Arg Val 
        275                 280                 285             


Thr Tyr Gln Asn His Asn Lys Thr Leu Gln Leu Leu Lys Val Gly Glu 
    290                 295                 300                 


Glu Asp Asp Gly Glu Tyr Arg Cys Leu Ala Glu Asn Ser Leu Gly Ser 
305                 310                 315                 320 


Ala Arg His Ala Tyr Tyr Val Thr Val Glu Ala Ala Pro Tyr Trp Leu 
                325                 330                 335     


His Lys Pro Gln Ser His Leu Tyr Gly Pro Gly Glu Thr Ala Arg Leu 
            340                 345                 350         


Asp Cys Gln Val Gln Gly Arg Pro Gln Pro Glu Val Thr Trp Arg Ile 
        355                 360                 365             


Asn Gly Ile Pro Val Glu Glu Leu Ala Lys Asp Gln Lys Tyr Arg Ile 
    370                 375                 380                 


Gln Arg Gly Ala Leu Ile Leu Ser Asn Val Gln Pro Ser Asp Thr Met 
385                 390                 395                 400 


Val Thr Gln Cys Glu Ala Arg Asn Arg His Gly Leu Leu Leu Ala Asn 
                405                 410                 415     


Ala Tyr Ile Tyr Val Val Gln Leu Pro Ala Lys Ile Leu Thr Ala Asp 
            420                 425                 430         


Asn Gln Thr Tyr Met Ala Val Gln Gly Ser Thr Ala Tyr Leu Leu Cys 
        435                 440                 445             


Lys Ala Phe Gly Ala Pro Val Pro Ser Val Gln Trp Leu Asp Glu Asp 
    450                 455                 460                 


Gly Thr Thr Val Leu Gln Asp Glu Arg Phe Phe Pro Tyr Ala Asn Gly 
465                 470                 475                 480 


Thr Leu Gly Ile Arg Asp Leu Gln Ala Asn Asp Thr Gly Arg Tyr Phe 
                485                 490                 495     


Cys Leu Ala Ala Asn Asp Gln Asn Asn Val Thr Ile Met Ala Asn Leu 
            500                 505                 510         


Lys Val Lys Asp Ala Thr Gln Ile Thr Gln Gly Pro Arg Ser Thr Ile 
        515                 520                 525             


Glu Lys Lys Gly Ser Arg Val Thr Phe Thr Cys Gln Ala Ser Phe Asp 
    530                 535                 540                 


Pro Ser Leu Gln Pro Ser Ile Thr Trp Arg Gly Asp Gly Arg Asp Leu 
545                 550                 555                 560 


Gln Glu Leu Gly Asp Ser Asp Lys Tyr Phe Ile Glu Asp Gly Arg Leu 
                565                 570                 575     


Val Ile His Ser Leu Asp Tyr Ser Asp Gln Gly Asn Tyr Ser Cys Val 
            580                 585                 590         


Ala Ser Thr Glu Leu Asp Val Val Glu Ser Arg Ala Gln Leu Leu Val 
        595                 600                 605             


Val Gly Ser Pro Gly Pro Val Pro Arg Leu Val Leu Ser Asp Leu His 
    610                 615                 620                 


Leu Leu Thr Gln Ser Gln Val Arg Val Ser Trp Ser Pro Ala Glu Asp 
625                 630                 635                 640 


His Asn Ala Pro Ile Glu Lys Tyr Asp Ile Glu Phe Glu Asp Lys Glu 
                645                 650                 655     


Met Ala Pro Glu Lys Trp Tyr Ser Leu Gly Lys Val Pro Gly Asn Gln 
            660                 665                 670         


Thr Ser Thr Thr Leu Lys Leu Ser Pro Tyr Val His Tyr Thr Phe Arg 
        675                 680                 685             


Val Thr Ala Ile Asn Lys Tyr Gly Pro Gly Glu Pro Ser Pro Val Ser 
    690                 695                 700                 


Glu Thr Val Val Thr Pro Glu Ala Ala Pro Glu Lys Asn Pro Val Asp 
705                 710                 715                 720 


Val Lys Gly Glu Gly Asn Glu Thr Thr Asn Met Val Ile Thr Trp Lys 
                725                 730                 735     


Pro Leu Arg Trp Met Asp Trp Asn Ala Pro Gln Val Gln Tyr Arg Val 
            740                 745                 750         


Gln Trp Arg Pro Gln Gly Thr Arg Gly Pro Trp Gln Glu Gln Ile Val 
        755                 760                 765             


Ser Asp Pro Phe Leu Val Val Ser Asn Thr Ser Thr Phe Val Pro Tyr 
    770                 775                 780                 


Glu Ile Lys Val Gln Ala Val Asn Ser Gln Gly Lys Gly Pro Glu Pro 
785                 790                 795                 800 


Gln Val Thr Ile Gly Tyr Ser Gly Glu Asp Tyr Pro Gln Ala Ile Pro 
                805                 810                 815     


Glu Leu Glu Gly Ile Glu Ile Leu Asn Ser Ser Ala Val Leu Val Lys 
            820                 825                 830         


Trp Arg Pro Val Asp Leu Ala Gln Val Lys Gly His Leu Arg Gly Tyr 
        835                 840                 845             


Asn Val Thr Tyr Trp Arg Glu Gly Ser Gln Arg Lys His Ser Lys Arg 
    850                 855                 860                 


His Ile His Lys Asp His Val Val Val Pro Ala Asn Thr Thr Ser Val 
865                 870                 875                 880 


Ile Leu Ser Gly Leu Arg Pro Tyr Ser Ser Tyr His Leu Glu Val Gln 
                885                 890                 895     


Ala Phe Asn Gly Arg Gly Ser Gly Pro Ala Ser Glu Phe Thr Phe Ser 
            900                 905                 910         


Thr Pro Glu Gly Val Pro Gly His Pro Glu Ala Leu His Leu Glu Cys 
        915                 920                 925             


Gln Ser Asn Thr Ser Leu Leu Leu Arg Trp Gln Pro Pro Leu Ser His 
    930                 935                 940                 


Asn Gly Val Leu Thr Gly Tyr Val Leu Ser Tyr His Pro Leu Asp Glu 
945                 950                 955                 960 


Gly Gly Lys Gly Gln Leu Ser Phe Asn Leu Arg Asp Pro Glu Leu Arg 
                965                 970                 975     


Thr His Asn Leu Thr Asp Leu Ser Pro His Leu Arg Tyr Arg Phe Gln 
            980                 985                 990         


Leu Gln Ala Thr Thr Lys Glu Gly  Pro Gly Glu Ala Ile  Val Arg Glu 
        995                 1000                 1005             


Gly Gly  Thr Met Ala Leu Ser  Gly Ile Ser Asp Phe  Gly Asn Ile 
    1010                 1015                 1020             


Ser Ala  Thr Ala Gly Glu Asn  Tyr Ser Val Val Ser  Trp Val Pro 
    1025                 1030                 1035             


Lys Glu  Gly Gln Cys Asn Phe  Arg Phe His Ile Leu  Phe Lys Ala 
    1040                 1045                 1050             


Leu Gly  Glu Glu Lys Gly Gly  Ala Ser Leu Ser Pro  Gln Tyr Val 
    1055                 1060                 1065             


Ser Tyr  Asn Gln Ser Ser Tyr  Thr Gln Trp Asp Leu  Gln Pro Asp 
    1070                 1075                 1080             


Thr Asp  Tyr Glu Ile His Leu  Phe Lys Glu Arg Met  Phe Arg His 
    1085                 1090                 1095             


Gln Met  Ala Val Lys Thr Asn  Gly Thr Gly Arg Val  Arg Leu Pro 
    1100                 1105                 1110             


Pro Ala  Gly Phe Ala Thr Glu  Gly Trp Phe Ile Gly  Phe Val Ser 
    1115                 1120                 1125             


Ala Ile  Ile Leu Leu Leu Leu  Val Leu Leu Ile Leu  Cys Phe Ile 
    1130                 1135                 1140             


Lys Arg  Ser Lys Gly Gly Lys  Tyr Ser Val Lys Asp  Lys Glu Asp 
    1145                 1150                 1155             


Thr Gln  Val Asp Ser Glu Ala  Arg Pro Met Lys Asp  Glu Thr Phe 
    1160                 1165                 1170             


Gly Glu  Tyr Arg Ser Leu Glu  Ser Asp Asn Glu Glu  Lys Ala Phe 
    1175                 1180                 1185             


Gly Ser  Ser Gln Pro Ser Leu  Asn Gly Asp Ile Lys  Pro Leu Gly 
    1190                 1195                 1200             


Ser Asp  Asp Ser Leu Ala Asp  Tyr Gly Gly Ser Val  Asp Val Gln 
    1205                 1210                 1215             


Phe Asn  Glu Asp Gly Ser Phe  Ile Gly Gln Tyr Ser  Gly Lys Lys 
    1220                 1225                 1230             


Glu Lys  Glu Ala Ala Gly Gly  Asn Asp Ser Ser Gly  Ala Thr Ser 
    1235                 1240                 1245             


Pro Ile  Asn Pro Ala Val Ala  Leu Glu 
    1250                 1255         


<210>  127
<211>  780
<212>  PRT
<213>  Homo sapiens

<400>  127

Met Ala Ala Pro Gly Gly Arg Ser Glu Pro Pro Gln Leu Pro Glu Tyr 
1               5                   10                  15      


Ser Cys Ser Tyr Met Val Ser Arg Pro Val Tyr Ser Glu Leu Ala Phe 
            20                  25                  30          


Gln Gln Gln His Glu Arg Arg Leu Gln Glu Arg Lys Thr Leu Arg Glu 
        35                  40                  45              


Ser Leu Ala Lys Cys Cys Ser Cys Ser Arg Lys Arg Ala Phe Gly Val 
    50                  55                  60                  


Leu Lys Thr Leu Val Pro Ile Leu Glu Trp Leu Pro Lys Tyr Arg Val 
65                  70                  75                  80  


Lys Glu Trp Leu Leu Ser Asp Val Ile Ser Gly Val Ser Thr Gly Leu 
                85                  90                  95      


Val Ala Thr Leu Gln Gly Met Ala Tyr Ala Leu Leu Ala Ala Val Pro 
            100                 105                 110         


Val Gly Tyr Gly Leu Tyr Ser Ala Phe Phe Pro Ile Leu Thr Tyr Phe 
        115                 120                 125             


Ile Phe Gly Thr Ser Arg His Ile Ser Val Gly Pro Phe Pro Val Val 
    130                 135                 140                 


Ser Leu Met Val Gly Ser Val Val Leu Ser Met Ala Pro Asp Glu His 
145                 150                 155                 160 


Phe Leu Val Ser Ser Ser Asn Gly Thr Val Leu Asn Thr Thr Met Ile 
                165                 170                 175     


Asp Thr Ala Ala Arg Asp Thr Ala Arg Val Leu Ile Ala Ser Ala Leu 
            180                 185                 190         


Thr Leu Leu Val Gly Ile Ile Gln Leu Ile Phe Gly Gly Leu Gln Ile 
        195                 200                 205             


Gly Phe Ile Val Arg Tyr Leu Ala Asp Pro Leu Val Gly Gly Phe Thr 
    210                 215                 220                 


Thr Ala Ala Ala Phe Gln Val Leu Val Ser Gln Leu Lys Ile Val Leu 
225                 230                 235                 240 


Asn Val Ser Thr Lys Asn Tyr Asn Gly Val Leu Ser Ile Ile Tyr Thr 
                245                 250                 255     


Leu Val Glu Ile Phe Gln Asn Ile Gly Asp Thr Asn Leu Ala Asp Phe 
            260                 265                 270         


Thr Ala Gly Leu Leu Thr Ile Val Val Cys Met Ala Val Lys Glu Leu 
        275                 280                 285             


Asn Asp Arg Phe Arg His Lys Ile Pro Val Pro Ile Pro Ile Glu Val 
    290                 295                 300                 


Ile Val Thr Ile Ile Ala Thr Ala Ile Ser Tyr Gly Ala Asn Leu Glu 
305                 310                 315                 320 


Lys Asn Tyr Asn Ala Gly Ile Val Lys Ser Ile Pro Arg Gly Phe Leu 
                325                 330                 335     


Pro Pro Glu Leu Pro Pro Val Ser Leu Phe Ser Glu Met Leu Ala Ala 
            340                 345                 350         


Ser Phe Ser Ile Ala Val Val Ala Tyr Ala Ile Ala Val Ser Val Gly 
        355                 360                 365             


Lys Val Tyr Ala Thr Lys Tyr Asp Tyr Thr Ile Asp Gly Asn Gln Glu 
    370                 375                 380                 


Phe Ile Ala Phe Gly Ile Ser Asn Ile Phe Ser Gly Phe Phe Ser Cys 
385                 390                 395                 400 


Phe Val Ala Thr Thr Ala Leu Ser Arg Thr Ala Val Gln Glu Ser Thr 
                405                 410                 415     


Gly Gly Lys Thr Gln Val Ala Gly Ile Ile Ser Ala Ala Ile Val Met 
            420                 425                 430         


Ile Ala Ile Leu Ala Leu Gly Lys Leu Leu Glu Pro Leu Gln Lys Ser 
        435                 440                 445             


Val Leu Ala Ala Val Val Ile Ala Asn Leu Lys Gly Met Phe Met Gln 
    450                 455                 460                 


Leu Cys Asp Ile Pro Arg Leu Trp Arg Gln Asn Lys Ile Asp Ala Val 
465                 470                 475                 480 


Ile Trp Val Phe Thr Cys Ile Val Ser Ile Ile Leu Gly Leu Asp Leu 
                485                 490                 495     


Gly Leu Leu Ala Gly Leu Ile Phe Gly Leu Leu Thr Val Val Leu Arg 
            500                 505                 510         


Val Gln Phe Pro Ser Trp Asn Gly Leu Gly Ser Ile Pro Ser Thr Asp 
        515                 520                 525             


Ile Tyr Lys Ser Thr Lys Asn Tyr Lys Asn Ile Glu Glu Pro Gln Gly 
    530                 535                 540                 


Val Lys Ile Leu Arg Phe Ser Ser Pro Ile Phe Tyr Gly Asn Val Asp 
545                 550                 555                 560 


Gly Phe Lys Lys Cys Ile Lys Ser Thr Val Gly Phe Asp Ala Ile Arg 
                565                 570                 575     


Val Tyr Asn Lys Arg Leu Lys Ala Leu Arg Lys Ile Gln Lys Leu Ile 
            580                 585                 590         


Lys Ser Gly Gln Leu Arg Ala Thr Lys Asn Gly Ile Ile Ser Asp Ala 
        595                 600                 605             


Val Ser Thr Asn Asn Ala Phe Glu Pro Asp Glu Asp Ile Glu Asp Leu 
    610                 615                 620                 


Glu Glu Leu Asp Ile Pro Thr Lys Glu Ile Glu Ile Gln Val Asp Trp 
625                 630                 635                 640 


Asn Ser Glu Leu Pro Val Lys Val Asn Val Pro Lys Val Pro Ile His 
                645                 650                 655     


Ser Leu Val Leu Asp Cys Gly Ala Ile Ser Phe Leu Asp Val Val Gly 
            660                 665                 670         


Val Arg Ser Leu Arg Val Ile Val Lys Glu Phe Gln Arg Ile Asp Val 
        675                 680                 685             


Asn Val Tyr Phe Ala Ser Leu Gln Asp Tyr Val Ile Glu Lys Leu Glu 
    690                 695                 700                 


Gln Cys Gly Phe Phe Asp Asp Asn Ile Arg Lys Asp Thr Phe Phe Leu 
705                 710                 715                 720 


Thr Val His Asp Ala Ile Leu Tyr Leu Gln Asn Gln Val Lys Ser Gln 
                725                 730                 735     


Glu Gly Gln Gly Ser Ile Leu Glu Thr Ile Thr Leu Ile Gln Asp Cys 
            740                 745                 750         


Lys Asp Thr Leu Glu Leu Ile Glu Thr Glu Leu Thr Glu Glu Glu Leu 
        755                 760                 765             


Asp Val Gln Asp Glu Ala Met Arg Thr Leu Ala Ser 
    770                 775                 780 


<210>  128
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  128

Met Gln Pro Arg Trp Ala Gln Gly Ala Thr Met Trp Leu Gly Val Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Cys Ser Ser Leu Glu Gly Gln Glu Asn Ser Phe 
            20                  25                  30          


Thr Ile Asn Ser Val Asp Met Lys Ser Leu Pro Asp Trp Thr Val Gln 
        35                  40                  45              


Asn Gly Lys Asn Leu Thr Leu Gln Cys Phe Ala Asp Val Ser Thr Thr 
    50                  55                  60                  


Ser His Val Lys Pro Gln His Gln Met Leu Phe Tyr Lys Asp Asp Val 
65                  70                  75                  80  


Leu Phe Tyr Asn Ile Ser Ser Met Lys Ser Thr Glu Ser Tyr Phe Ile 
                85                  90                  95      


Pro Glu Val Arg Ile Tyr Asp Ser Gly Thr Tyr Lys Cys Thr Val Ile 
            100                 105                 110         


Val Asn Asn Lys Glu Lys Thr Thr Ala Glu Tyr Gln Val Leu Val Glu 
        115                 120                 125             


Gly Val Pro Ser Pro Arg Val Thr Leu Asp Lys Lys Glu Ala Ile Gln 
    130                 135                 140                 


Gly Gly Ile Val Arg Val Asn Cys Ser Val Pro Glu Glu Lys Ala Pro 
145                 150                 155                 160 


Ile His Phe Thr Ile Glu Lys Leu Glu Leu Asn Glu Lys Met Val Lys 
                165                 170                 175     


Leu Lys Arg Glu Lys Asn Ser Arg Asp Gln Asn Phe Val Ile Leu Glu 
            180                 185                 190         


Phe Pro Val Glu Glu Gln Asp Arg Val Leu Ser Phe Arg Cys Gln Ala 
        195                 200                 205             


Arg Ile Ile Ser Gly Ile His Met Gln Thr Ser Glu Ser Thr Lys Ser 
    210                 215                 220                 


Glu Leu Val Thr Val Thr Glu Ser Phe Ser Thr Pro Lys Phe His Ile 
225                 230                 235                 240 


Ser Pro Thr Gly Met Ile Met Glu Gly Ala Gln Leu His Ile Lys Cys 
                245                 250                 255     


Thr Ile Gln Val Thr His Leu Ala Gln Glu Phe Pro Glu Ile Ile Ile 
            260                 265                 270         


Gln Lys Asp Lys Ala Ile Val Ala His Asn Arg His Gly Asn Lys Ala 
        275                 280                 285             


Val Tyr Ser Val Met Ala Met Val Glu His Ser Gly Asn Tyr Thr Cys 
    290                 295                 300                 


Lys Val Glu Ser Ser Arg Ile Ser Lys Val Ser Ser Ile Val Val Asn 
305                 310                 315                 320 


Ile Thr Glu Leu Phe Ser Lys Pro Glu Leu Glu Ser Ser Phe Thr His 
                325                 330                 335     


Leu Asp Gln Gly Glu Arg Leu Asn Leu Ser Cys Ser Ile Pro Gly Ala 
            340                 345                 350         


Pro Pro Ala Asn Phe Thr Ile Gln Lys Glu Asp Thr Ile Val Ser Gln 
        355                 360                 365             


Thr Gln Asp Phe Thr Lys Ile Ala Ser Lys Ser Asp Ser Gly Thr Tyr 
    370                 375                 380                 


Ile Cys Thr Ala Gly Ile Asp Lys Val Val Lys Lys Ser Asn Thr Val 
385                 390                 395                 400 


Gln Ile Val Val Cys Glu Met Leu Ser Gln Pro Arg Ile Ser Tyr Asp 
                405                 410                 415     


Ala Gln Phe Glu Val Ile Lys Gly Gln Thr Ile Glu Val Arg Cys Glu 
            420                 425                 430         


Ser Ile Ser Gly Thr Leu Pro Ile Ser Tyr Gln Leu Leu Lys Thr Ser 
        435                 440                 445             


Lys Val Leu Glu Asn Ser Thr Lys Asn Ser Asn Asp Pro Ala Val Phe 
    450                 455                 460                 


Lys Asp Asn Pro Thr Glu Asp Val Glu Tyr Gln Cys Val Ala Asp Asn 
465                 470                 475                 480 


Cys His Ser His Ala Lys Met Leu Ser Glu Val Leu Arg Val Lys Val 
                485                 490                 495     


Ile Ala Pro Val Asp Glu Val Gln Ile Ser Ile Leu Ser Ser Lys Val 
            500                 505                 510         


Val Glu Ser Gly Glu Asp Ile Val Leu Gln Cys Ala Val Asn Glu Gly 
        515                 520                 525             


Ser Gly Pro Ile Thr Tyr Lys Phe Tyr Arg Glu Lys Glu Gly Lys Pro 
    530                 535                 540                 


Phe Tyr Gln Met Thr Ser Asn Ala Thr Gln Ala Phe Trp Thr Lys Gln 
545                 550                 555                 560 


Lys Ala Ser Lys Glu Gln Glu Gly Glu Tyr Tyr Cys Thr Ala Phe Asn 
                565                 570                 575     


Arg Ala Asn His Ala Ser Ser Val Pro Arg Ser Lys Ile Leu Thr Val 
            580                 585                 590         


Arg Val Ile Leu Ala Pro Trp Lys Lys Gly Leu Ile Ala Val Val Ile 
        595                 600                 605             


Ile Gly Val Ile Ile Ala Leu Leu Ile Ile Ala Ala Lys Cys Tyr Phe 
    610                 615                 620                 


Leu Arg Lys Ala Lys Ala Lys Gln Met Pro Val Glu Met Ser Arg Pro 
625                 630                 635                 640 


Ala Val Pro Leu Leu Asn Ser Asn Asn Glu Lys Met Ser Asp Pro Asn 
                645                 650                 655     


Met Glu Ala Asn Ser His Tyr Gly His Asn Asp Asp Val Arg Asn His 
            660                 665                 670         


Ala Met Lys Pro Ile Asn Asp Asn Lys Glu Pro Leu Asn Ser Asp Val 
        675                 680                 685             


Gln Tyr Thr Glu Val Gln Val Ser Ser Ala Glu Ser His Lys Asp Leu 
    690                 695                 700                 


Gly Lys Lys Asp Thr Glu Thr Val Tyr Ser Glu Val Arg Lys Ala Val 
705                 710                 715                 720 


Pro Asp Ala Val Glu Ser Arg Tyr Ser Arg Thr Glu Gly Ser Leu Asp 
                725                 730                 735     


Gly Thr 
        


<210>  129
<211>  1279
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Asp Leu Glu Ala Ala Lys Asn Gly Thr Ala Trp Arg Pro Thr Ser 
1               5                   10                  15      


Ala Glu Gly Asp Phe Glu Leu Gly Ile Ser Ser Lys Gln Lys Arg Lys 
            20                  25                  30          


Lys Thr Lys Thr Val Lys Met Ile Gly Val Leu Thr Leu Phe Arg Tyr 
        35                  40                  45              


Ser Asp Trp Gln Asp Lys Leu Phe Met Ser Leu Gly Thr Ile Met Ala 
    50                  55                  60                  


Ile Ala His Gly Ser Gly Leu Pro Leu Met Met Ile Val Phe Gly Glu 
65                  70                  75                  80  


Met Thr Asp Lys Phe Val Asp Thr Ala Gly Asn Phe Ser Phe Pro Val 
                85                  90                  95      


Asn Phe Ser Leu Ser Leu Leu Asn Pro Gly Lys Ile Leu Glu Glu Glu 
            100                 105                 110         


Met Thr Arg Tyr Ala Tyr Tyr Tyr Ser Gly Leu Gly Ala Gly Val Leu 
        115                 120                 125             


Val Ala Ala Tyr Ile Gln Val Ser Phe Trp Thr Leu Ala Ala Gly Arg 
    130                 135                 140                 


Gln Ile Arg Lys Ile Arg Gln Lys Phe Phe His Ala Ile Leu Arg Gln 
145                 150                 155                 160 


Glu Ile Gly Trp Phe Asp Ile Asn Asp Thr Thr Glu Leu Asn Thr Arg 
                165                 170                 175     


Leu Thr Asp Asp Ile Ser Lys Ile Ser Glu Gly Ile Gly Asp Lys Val 
            180                 185                 190         


Gly Met Phe Phe Gln Ala Val Ala Thr Phe Phe Ala Gly Phe Ile Val 
        195                 200                 205             


Gly Phe Ile Arg Gly Trp Lys Leu Thr Leu Val Ile Met Ala Ile Ser 
    210                 215                 220                 


Pro Ile Leu Gly Leu Ser Ala Ala Val Trp Ala Lys Ile Leu Ser Ala 
225                 230                 235                 240 


Phe Ser Asp Lys Glu Leu Ala Ala Tyr Ala Lys Ala Gly Ala Val Ala 
                245                 250                 255     


Glu Glu Ala Leu Gly Ala Ile Arg Thr Val Ile Ala Phe Gly Gly Gln 
            260                 265                 270         


Asn Lys Glu Leu Glu Arg Tyr Gln Lys His Leu Glu Asn Ala Lys Glu 
        275                 280                 285             


Ile Gly Ile Lys Lys Ala Ile Ser Ala Asn Ile Ser Met Gly Ile Ala 
    290                 295                 300                 


Phe Leu Leu Ile Tyr Ala Ser Tyr Ala Leu Ala Phe Trp Tyr Gly Ser 
305                 310                 315                 320 


Thr Leu Val Ile Ser Lys Glu Tyr Thr Ile Gly Asn Ala Met Thr Val 
                325                 330                 335     


Phe Phe Ser Ile Leu Ile Gly Ala Phe Ser Val Gly Gln Ala Ala Pro 
            340                 345                 350         


Cys Ile Asp Ala Phe Ala Asn Ala Arg Gly Ala Ala Tyr Val Ile Phe 
        355                 360                 365             


Asp Ile Ile Asp Asn Asn Pro Lys Ile Asp Ser Phe Ser Glu Arg Gly 
    370                 375                 380                 


His Lys Pro Asp Ser Ile Lys Gly Asn Leu Glu Phe Asn Asp Val His 
385                 390                 395                 400 


Phe Ser Tyr Pro Ser Arg Ala Asn Val Lys Ile Leu Lys Gly Leu Asn 
                405                 410                 415     


Leu Lys Val Gln Ser Gly Gln Thr Val Ala Leu Val Gly Ser Ser Gly 
            420                 425                 430         


Cys Gly Lys Ser Thr Thr Val Gln Leu Ile Gln Arg Leu Tyr Asp Pro 
        435                 440                 445             


Asp Glu Gly Thr Ile Asn Ile Asp Gly Gln Asp Ile Arg Asn Phe Asn 
    450                 455                 460                 


Val Asn Tyr Leu Arg Glu Ile Ile Gly Val Val Ser Gln Glu Pro Val 
465                 470                 475                 480 


Leu Phe Ser Thr Thr Ile Ala Glu Asn Ile Cys Tyr Gly Arg Gly Asn 
                485                 490                 495     


Val Thr Met Asp Glu Ile Lys Lys Ala Val Lys Glu Ala Asn Ala Tyr 
            500                 505                 510         


Glu Phe Ile Met Lys Leu Pro Gln Lys Phe Asp Thr Leu Val Gly Glu 
        515                 520                 525             


Arg Gly Ala Gln Leu Ser Gly Gly Gln Lys Gln Arg Ile Ala Ile Ala 
    530                 535                 540                 


Arg Ala Leu Val Arg Asn Pro Lys Ile Leu Leu Leu Asp Glu Ala Thr 
545                 550                 555                 560 


Ser Ala Leu Asp Thr Glu Ser Glu Ala Glu Val Gln Ala Ala Leu Asp 
                565                 570                 575     


Lys Ala Arg Glu Gly Arg Thr Thr Ile Val Ile Ala His Arg Leu Ser 
            580                 585                 590         


Thr Val Arg Asn Ala Asp Val Ile Ala Gly Phe Glu Asp Gly Val Ile 
        595                 600                 605             


Val Glu Gln Gly Ser His Ser Glu Leu Met Lys Lys Glu Gly Val Tyr 
    610                 615                 620                 


Phe Lys Leu Val Asn Met Gln Thr Ser Gly Ser Gln Ile Gln Ser Glu 
625                 630                 635                 640 


Glu Phe Glu Leu Asn Asp Glu Lys Ala Ala Thr Arg Met Ala Pro Asn 
                645                 650                 655     


Gly Trp Lys Ser Arg Leu Phe Arg His Ser Thr Gln Lys Asn Leu Lys 
            660                 665                 670         


Asn Ser Gln Met Cys Gln Lys Ser Leu Asp Val Glu Thr Asp Gly Leu 
        675                 680                 685             


Glu Ala Asn Val Pro Pro Val Ser Phe Leu Lys Val Leu Lys Leu Asn 
    690                 695                 700                 


Lys Thr Glu Trp Pro Tyr Phe Val Val Gly Thr Val Cys Ala Ile Ala 
705                 710                 715                 720 


Asn Gly Gly Leu Gln Pro Ala Phe Ser Val Ile Phe Ser Glu Ile Ile 
                725                 730                 735     


Ala Ile Phe Gly Pro Gly Asp Asp Ala Val Lys Gln Gln Lys Cys Asn 
            740                 745                 750         


Ile Phe Ser Leu Ile Phe Leu Phe Leu Gly Ile Ile Ser Phe Phe Thr 
        755                 760                 765             


Phe Phe Leu Gln Gly Phe Thr Phe Gly Lys Ala Gly Glu Ile Leu Thr 
    770                 775                 780                 


Arg Arg Leu Arg Ser Met Ala Phe Lys Ala Met Leu Arg Gln Asp Met 
785                 790                 795                 800 


Ser Trp Phe Asp Asp His Lys Asn Ser Thr Gly Ala Leu Ser Thr Arg 
                805                 810                 815     


Leu Ala Thr Asp Ala Ala Gln Val Gln Gly Ala Thr Gly Thr Arg Leu 
            820                 825                 830         


Ala Leu Ile Ala Gln Asn Ile Ala Asn Leu Gly Thr Gly Ile Ile Ile 
        835                 840                 845             


Ser Phe Ile Tyr Gly Trp Gln Leu Thr Leu Leu Leu Leu Ala Val Val 
    850                 855                 860                 


Pro Ile Ile Ala Val Ser Gly Ile Val Glu Met Lys Leu Leu Ala Gly 
865                 870                 875                 880 


Asn Ala Lys Arg Asp Lys Lys Glu Leu Glu Ala Ala Gly Lys Ile Ala 
                885                 890                 895     


Thr Glu Ala Ile Glu Asn Ile Arg Thr Val Val Ser Leu Thr Gln Glu 
            900                 905                 910         


Arg Lys Phe Glu Ser Met Tyr Val Glu Lys Leu Tyr Gly Pro Tyr Arg 
        915                 920                 925             


Asn Ser Val Gln Lys Ala His Ile Tyr Gly Ile Thr Phe Ser Ile Ser 
    930                 935                 940                 


Gln Ala Phe Met Tyr Phe Ser Tyr Ala Gly Cys Phe Arg Phe Gly Ala 
945                 950                 955                 960 


Tyr Leu Ile Val Asn Gly His Met Arg Phe Arg Asp Val Ile Leu Val 
                965                 970                 975     


Phe Ser Ala Ile Val Phe Gly Ala Val Ala Leu Gly His Ala Ser Ser 
            980                 985                 990         


Phe Ala Pro Asp Tyr Ala Lys Ala  Lys Leu Ser Ala Ala  His Leu Phe 
        995                 1000                 1005             


Met Leu  Phe Glu Arg Gln Pro  Leu Ile Asp Ser Tyr  Ser Glu Glu 
    1010                 1015                 1020             


Gly Leu  Lys Pro Asp Lys Phe  Glu Gly Asn Ile Thr  Phe Asn Glu 
    1025                 1030                 1035             


Val Val  Phe Asn Tyr Pro Thr  Arg Ala Asn Val Pro  Val Leu Gln 
    1040                 1045                 1050             


Gly Leu  Ser Leu Glu Val Lys  Lys Gly Gln Thr Leu  Ala Leu Val 
    1055                 1060                 1065             


Gly Ser  Ser Gly Cys Gly Lys  Ser Thr Val Val Gln  Leu Leu Glu 
    1070                 1075                 1080             


Arg Phe  Tyr Asp Pro Leu Ala  Gly Thr Val Leu Leu  Asp Gly Gln 
    1085                 1090                 1095             


Glu Ala  Lys Lys Leu Asn Val  Gln Trp Leu Arg Ala  Gln Leu Gly 
    1100                 1105                 1110             


Ile Val  Ser Gln Glu Pro Ile  Leu Phe Asp Cys Ser  Ile Ala Glu 
    1115                 1120                 1125             


Asn Ile  Ala Tyr Gly Asp Asn  Ser Arg Val Val Ser  Gln Asp Glu 
    1130                 1135                 1140             


Ile Val  Ser Ala Ala Lys Ala  Ala Asn Ile His Pro  Phe Ile Glu 
    1145                 1150                 1155             


Thr Leu  Pro His Lys Tyr Glu  Thr Arg Val Gly Asp  Lys Gly Thr 
    1160                 1165                 1170             


Gln Leu  Ser Gly Gly Gln Lys  Gln Arg Ile Ala Ile  Ala Arg Ala 
    1175                 1180                 1185             


Leu Ile  Arg Gln Pro Gln Ile  Leu Leu Leu Asp Glu  Ala Thr Ser 
    1190                 1195                 1200             


Ala Leu  Asp Thr Glu Ser Glu  Lys Val Val Gln Glu  Ala Leu Asp 
    1205                 1210                 1215             


Lys Ala  Arg Glu Gly Arg Thr  Cys Ile Val Ile Ala  His Arg Leu 
    1220                 1225                 1230             


Ser Thr  Ile Gln Asn Ala Asp  Leu Ile Val Val Phe  Gln Asn Gly 
    1235                 1240                 1245             


Arg Val  Lys Glu His Gly Thr  His Gln Gln Leu Leu  Ala Gln Lys 
    1250                 1255                 1260             


Gly Ile  Tyr Phe Ser Met Val  Ser Val Gln Ala Gly  Thr Gln Asn 
    1265                 1270                 1275             


Leu 
    


<210>  130
<211>  749
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Glu Ala Glu Thr Gly Ser Ser Val Glu Thr Gly Lys Lys Ala Asn 
1               5                   10                  15      


Arg Gly Thr Arg Ile Ala Leu Val Val Phe Val Gly Gly Thr Leu Val 
            20                  25                  30          


Leu Gly Thr Ile Leu Phe Leu Val Ser Gln Gly Leu Leu Ser Leu Gln 
        35                  40                  45              


Ala Lys Gln Glu Tyr Cys Leu Lys Pro Glu Cys Ile Glu Ala Ala Ala 
    50                  55                  60                  


Ala Ile Leu Ser Lys Val Asn Leu Ser Val Asp Pro Cys Asp Asn Phe 
65                  70                  75                  80  


Phe Arg Phe Ala Cys Asp Gly Trp Ile Ser Asn Asn Pro Ile Pro Glu 
                85                  90                  95      


Asp Met Pro Ser Tyr Gly Val Tyr Pro Trp Leu Arg His Asn Val Asp 
            100                 105                 110         


Leu Lys Leu Lys Glu Leu Leu Glu Lys Ser Ile Ser Arg Arg Arg Asp 
        115                 120                 125             


Thr Glu Ala Ile Gln Lys Ala Lys Ile Leu Tyr Ser Ser Cys Met Asn 
    130                 135                 140                 


Glu Lys Ala Ile Glu Lys Ala Asp Ala Lys Pro Leu Leu His Ile Leu 
145                 150                 155                 160 


Arg His Ser Pro Phe Arg Trp Pro Val Leu Glu Ser Asn Ile Gly Pro 
                165                 170                 175     


Glu Gly Val Trp Ser Glu Arg Lys Phe Ser Leu Leu Gln Thr Leu Ala 
            180                 185                 190         


Thr Phe Arg Gly Gln Tyr Ser Asn Ser Val Phe Ile Arg Leu Tyr Val 
        195                 200                 205             


Ser Pro Asp Asp Lys Ala Ser Asn Glu His Ile Leu Lys Leu Asp Gln 
    210                 215                 220                 


Ala Thr Leu Ser Leu Ala Val Arg Glu Asp Tyr Leu Asp Asn Ser Thr 
225                 230                 235                 240 


Glu Ala Lys Ser Tyr Arg Asp Ala Leu Tyr Lys Phe Met Val Asp Thr 
                245                 250                 255     


Ala Val Leu Leu Gly Ala Asn Ser Ser Arg Ala Glu His Asp Met Lys 
            260                 265                 270         


Ser Val Leu Arg Leu Glu Ile Lys Ile Ala Glu Ile Met Ile Pro His 
        275                 280                 285             


Glu Asn Arg Thr Ser Glu Ala Met Tyr Asn Lys Met Asn Ile Ser Glu 
    290                 295                 300                 


Leu Ser Ala Met Ile Pro Gln Phe Asp Trp Leu Gly Tyr Ile Lys Lys 
305                 310                 315                 320 


Val Ile Asp Thr Arg Leu Tyr Pro His Leu Lys Asp Ile Ser Pro Ser 
                325                 330                 335     


Glu Asn Val Val Val Arg Val Pro Gln Tyr Phe Lys Asp Leu Phe Arg 
            340                 345                 350         


Ile Leu Gly Ser Glu Arg Lys Lys Thr Ile Ala Asn Tyr Leu Val Trp 
        355                 360                 365             


Arg Met Val Tyr Ser Arg Ile Pro Asn Leu Ser Arg Arg Phe Gln Tyr 
    370                 375                 380                 


Arg Trp Leu Glu Phe Ser Arg Val Ile Gln Gly Thr Thr Thr Leu Leu 
385                 390                 395                 400 


Pro Gln Trp Asp Lys Cys Val Asn Phe Ile Glu Ser Ala Leu Pro Tyr 
                405                 410                 415     


Val Val Gly Lys Met Phe Val Asp Val Tyr Phe Gln Glu Asp Lys Lys 
            420                 425                 430         


Glu Met Met Glu Glu Leu Val Glu Gly Val Arg Trp Ala Phe Ile Asp 
        435                 440                 445             


Met Leu Glu Lys Glu Asn Glu Trp Met Asp Ala Gly Thr Lys Arg Lys 
    450                 455                 460                 


Ala Lys Glu Lys Ala Arg Ala Val Leu Ala Lys Val Gly Tyr Pro Glu 
465                 470                 475                 480 


Phe Ile Met Asn Asp Thr His Val Asn Glu Asp Leu Lys Ala Ile Lys 
                485                 490                 495     


Phe Ser Glu Ala Asp Tyr Phe Gly Asn Val Leu Gln Thr Arg Lys Tyr 
            500                 505                 510         


Leu Ala Gln Ser Asp Phe Phe Trp Leu Arg Lys Ala Val Pro Lys Thr 
        515                 520                 525             


Glu Trp Phe Thr Asn Pro Thr Thr Val Asn Ala Phe Tyr Ser Ala Ser 
    530                 535                 540                 


Thr Asn Gln Ile Arg Phe Pro Ala Gly Glu Leu Gln Lys Pro Phe Phe 
545                 550                 555                 560 


Trp Gly Thr Glu Tyr Pro Arg Ser Leu Ser Tyr Gly Ala Ile Gly Val 
                565                 570                 575     


Ile Val Gly His Glu Phe Thr His Gly Phe Asp Asn Asn Gly Arg Lys 
            580                 585                 590         


Tyr Asp Lys Asn Gly Asn Leu Asp Pro Trp Trp Ser Thr Glu Ser Glu 
        595                 600                 605             


Glu Lys Phe Lys Glu Lys Thr Lys Cys Met Ile Asn Gln Tyr Ser Asn 
    610                 615                 620                 


Tyr Tyr Trp Lys Lys Ala Gly Leu Asn Val Lys Gly Lys Arg Thr Leu 
625                 630                 635                 640 


Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Arg Glu Ala Phe Arg Ala 
                645                 650                 655     


Tyr Arg Lys Trp Ile Asn Asp Arg Arg Gln Gly Leu Glu Glu Pro Leu 
            660                 665                 670         


Leu Pro Gly Ile Thr Phe Thr Asn Asn Gln Leu Phe Phe Leu Ser Tyr 
        675                 680                 685             


Ala His Val Arg Cys Asn Ser Tyr Arg Pro Glu Ala Ala Arg Glu Gln 
    690                 695                 700                 


Val Gln Ile Gly Ala His Ser Pro Pro Gln Phe Arg Val Asn Gly Ala 
705                 710                 715                 720 


Ile Ser Asn Phe Glu Glu Phe Gln Lys Ala Phe Asn Cys Pro Pro Asn 
                725                 730                 735     


Ser Thr Met Asn Arg Gly Met Asp Ser Cys Arg Leu Trp 
            740                 745                 


<210>  131
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  131

Met Leu Thr Phe Met Ala Ser Asp Ser Glu Glu Glu Val Cys Asp Glu 
1               5                   10                  15      


Arg Thr Ser Leu Met Ser Ala Glu Ser Pro Thr Pro Arg Ser Cys Gln 
            20                  25                  30          


Glu Gly Arg Gln Gly Pro Glu Asp Gly Glu Asn Thr Ala Gln Trp Arg 
        35                  40                  45              


Ser Gln Glu Asn Glu Glu Asp Gly Glu Glu Asp Pro Asp Arg Tyr Val 
    50                  55                  60                  


Cys Ser Gly Val Pro Gly Arg Pro Pro Gly Leu Glu Glu Glu Leu Thr 
65                  70                  75                  80  


Leu Lys Tyr Gly Ala Lys His Val Ile Met Leu Phe Val Pro Val Thr 
                85                  90                  95      


Leu Cys Met Ile Val Val Val Ala Thr Ile Lys Ser Val Arg Phe Tyr 
            100                 105                 110         


Thr Glu Lys Asn Gly Gln Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr 
        115                 120                 125             


Pro Ser Val Gly Gln Arg Leu Leu Asn Ser Val Leu Asn Thr Leu Ile 
    130                 135                 140                 


Met Ile Ser Val Ile Val Val Met Thr Ile Phe Leu Val Val Leu Tyr 
145                 150                 155                 160 


Lys Tyr Arg Cys Tyr Lys Phe Ile His Gly Trp Leu Ile Met Ser Ser 
                165                 170                 175     


Leu Met Leu Leu Phe Leu Phe Thr Tyr Ile Tyr Leu Gly Glu Val Leu 
            180                 185                 190         


Lys Thr Tyr Asn Val Ala Met Asp Tyr Pro Thr Leu Leu Leu Thr Val 
        195                 200                 205             


Trp Asn Phe Gly Ala Val Gly Met Val Cys Ile His Trp Lys Gly Pro 
    210                 215                 220                 


Leu Val Leu Gln Gln Ala Tyr Leu Ile Met Ile Ser Ala Leu Met Ala 
225                 230                 235                 240 


Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp Ser Ala Trp Val Ile Leu 
                245                 250                 255     


Gly Ala Ile Ser Val Tyr Asp Leu Val Ala Val Leu Cys Pro Lys Gly 
            260                 265                 270         


Pro Leu Arg Met Leu Val Glu Thr Ala Gln Glu Arg Asn Glu Pro Ile 
        275                 280                 285             


Phe Pro Ala Leu Ile Tyr Ser Ser Ala Met Val Trp Thr Val Gly Met 
    290                 295                 300                 


Ala Lys Leu Asp Pro Ser Ser Gln Gly Ala Leu Gln Leu Pro Tyr Asp 
305                 310                 315                 320 


Pro Glu Met Glu Glu Asp Ser Tyr Asp Ser Phe Gly Glu Pro Ser Tyr 
                325                 330                 335     


Pro Glu Val Phe Glu Pro Pro Leu Thr Gly Tyr Pro Gly Glu Glu Leu 
            340                 345                 350         


Glu Glu Glu Glu Glu Arg Gly Val Lys Leu Gly Leu Gly Asp Phe Ile 
        355                 360                 365             


Phe Tyr Ser Val Leu Val Gly Lys Ala Ala Ala Thr Gly Ser Gly Asp 
    370                 375                 380                 


Trp Asn Thr Thr Leu Ala Cys Phe Val Ala Ile Leu Ile Gly Leu Cys 
385                 390                 395                 400 


Leu Thr Leu Leu Leu Leu Ala Val Phe Lys Lys Ala Leu Pro Ala Leu 
                405                 410                 415     


Pro Ile Ser Ile Thr Phe Gly Leu Ile Phe Tyr Phe Ser Thr Asp Asn 
            420                 425                 430         


Leu Val Arg Pro Phe Met Asp Thr Leu Ala Ser His Gln Leu Tyr Ile 
        435                 440                 445             


<210>  132
<211>  610
<212>  PRT
<213>  Homo sapiens

<400>  132

Met Ile Ala Ser Gln Phe Leu Ser Ala Leu Thr Leu Val Leu Leu Ile 
1               5                   10                  15      


Lys Glu Ser Gly Ala Trp Ser Tyr Asn Thr Ser Thr Glu Ala Met Thr 
            20                  25                  30          


Tyr Asp Glu Ala Ser Ala Tyr Cys Gln Gln Arg Tyr Thr His Leu Val 
        35                  40                  45              


Ala Ile Gln Asn Lys Glu Glu Ile Glu Tyr Leu Asn Ser Ile Leu Ser 
    50                  55                  60                  


Tyr Ser Pro Ser Tyr Tyr Trp Ile Gly Ile Arg Lys Val Asn Asn Val 
65                  70                  75                  80  


Trp Val Trp Val Gly Thr Gln Lys Pro Leu Thr Glu Glu Ala Lys Asn 
                85                  90                  95      


Trp Ala Pro Gly Glu Pro Asn Asn Arg Gln Lys Asp Glu Asp Cys Val 
            100                 105                 110         


Glu Ile Tyr Ile Lys Arg Glu Lys Asp Val Gly Met Trp Asn Asp Glu 
        115                 120                 125             


Arg Cys Ser Lys Lys Lys Leu Ala Leu Cys Tyr Thr Ala Ala Cys Thr 
    130                 135                 140                 


Asn Thr Ser Cys Ser Gly His Gly Glu Cys Val Glu Thr Ile Asn Asn 
145                 150                 155                 160 


Tyr Thr Cys Lys Cys Asp Pro Gly Phe Ser Gly Leu Lys Cys Glu Gln 
                165                 170                 175     


Ile Val Asn Cys Thr Ala Leu Glu Ser Pro Glu His Gly Ser Leu Val 
            180                 185                 190         


Cys Ser His Pro Leu Gly Asn Phe Ser Tyr Asn Ser Ser Cys Ser Ile 
        195                 200                 205             


Ser Cys Asp Arg Gly Tyr Leu Pro Ser Ser Met Glu Thr Met Gln Cys 
    210                 215                 220                 


Met Ser Ser Gly Glu Trp Ser Ala Pro Ile Pro Ala Cys Asn Val Val 
225                 230                 235                 240 


Glu Cys Asp Ala Val Thr Asn Pro Ala Asn Gly Phe Val Glu Cys Phe 
                245                 250                 255     


Gln Asn Pro Gly Ser Phe Pro Trp Asn Thr Thr Cys Thr Phe Asp Cys 
            260                 265                 270         


Glu Glu Gly Phe Glu Leu Met Gly Ala Gln Ser Leu Gln Cys Thr Ser 
        275                 280                 285             


Ser Gly Asn Trp Asp Asn Glu Lys Pro Thr Cys Lys Ala Val Thr Cys 
    290                 295                 300                 


Arg Ala Val Arg Gln Pro Gln Asn Gly Ser Val Arg Cys Ser His Ser 
305                 310                 315                 320 


Pro Ala Gly Glu Phe Thr Phe Lys Ser Ser Cys Asn Phe Thr Cys Glu 
                325                 330                 335     


Glu Gly Phe Met Leu Gln Gly Pro Ala Gln Val Glu Cys Thr Thr Gln 
            340                 345                 350         


Gly Gln Trp Thr Gln Gln Ile Pro Val Cys Glu Ala Phe Gln Cys Thr 
        355                 360                 365             


Ala Leu Ser Asn Pro Glu Arg Gly Tyr Met Asn Cys Leu Pro Ser Ala 
    370                 375                 380                 


Ser Gly Ser Phe Arg Tyr Gly Ser Ser Cys Glu Phe Ser Cys Glu Gln 
385                 390                 395                 400 


Gly Phe Val Leu Lys Gly Ser Lys Arg Leu Gln Cys Gly Pro Thr Gly 
                405                 410                 415     


Glu Trp Asp Asn Glu Lys Pro Thr Cys Glu Ala Val Arg Cys Asp Ala 
            420                 425                 430         


Val His Gln Pro Pro Lys Gly Leu Val Arg Cys Ala His Ser Pro Ile 
        435                 440                 445             


Gly Glu Phe Thr Tyr Lys Ser Ser Cys Ala Phe Ser Cys Glu Glu Gly 
    450                 455                 460                 


Phe Glu Leu His Gly Ser Thr Gln Leu Glu Cys Thr Ser Gln Gly Gln 
465                 470                 475                 480 


Trp Thr Glu Glu Val Pro Ser Cys Gln Val Val Lys Cys Ser Ser Leu 
                485                 490                 495     


Ala Val Pro Gly Lys Ile Asn Met Ser Cys Ser Gly Glu Pro Val Phe 
            500                 505                 510         


Gly Thr Val Cys Lys Phe Ala Cys Pro Glu Gly Trp Thr Leu Asn Gly 
        515                 520                 525             


Ser Ala Ala Arg Thr Cys Gly Ala Thr Gly His Trp Ser Gly Leu Leu 
    530                 535                 540                 


Pro Thr Cys Glu Ala Pro Thr Glu Ser Asn Ile Pro Leu Val Ala Gly 
545                 550                 555                 560 


Leu Ser Ala Ala Gly Leu Ser Leu Leu Thr Leu Ala Pro Phe Leu Leu 
                565                 570                 575     


Trp Leu Arg Lys Cys Leu Arg Lys Ala Lys Lys Phe Val Pro Ala Ser 
            580                 585                 590         


Ser Cys Gln Ser Leu Glu Ser Asp Gly Ser Tyr Gln Lys Pro Ser Tyr 
        595                 600                 605             


Ile Leu 
    610 


<210>  133
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  133

Met Asn Asp Pro Asn Ser Cys Val Asp Asn Ala Thr Val Cys Ser Gly 
1               5                   10                  15      


Ala Ser Cys Val Val Pro Glu Ser Asn Phe Asn Asn Ile Leu Ser Val 
            20                  25                  30          


Val Leu Ser Thr Val Leu Thr Ile Leu Leu Ala Leu Val Met Phe Ser 
        35                  40                  45              


Met Gly Cys Asn Val Glu Ile Lys Lys Phe Leu Gly His Ile Lys Arg 
    50                  55                  60                  


Pro Trp Gly Ile Cys Val Gly Phe Leu Cys Gln Phe Gly Ile Met Pro 
65                  70                  75                  80  


Leu Thr Gly Phe Ile Leu Ser Val Ala Phe Asp Ile Leu Pro Leu Gln 
                85                  90                  95      


Ala Val Val Val Leu Ile Ile Gly Cys Cys Pro Gly Gly Thr Ala Ser 
            100                 105                 110         


Asn Ile Leu Ala Tyr Trp Val Asp Gly Asp Met Asp Leu Ser Val Ser 
        115                 120                 125             


Met Thr Thr Cys Ser Thr Leu Leu Ala Leu Gly Met Met Pro Leu Cys 
    130                 135                 140                 


Leu Leu Ile Tyr Thr Lys Met Trp Val Asp Ser Gly Ser Ile Val Ile 
145                 150                 155                 160 


Pro Tyr Asp Asn Ile Gly Thr Ser Leu Val Ala Leu Val Val Pro Val 
                165                 170                 175     


Ser Ile Gly Met Phe Val Asn His Lys Trp Pro Gln Lys Ala Lys Ile 
            180                 185                 190         


Ile Leu Lys Ile Gly Ser Ile Ala Gly Ala Ile Leu Ile Val Leu Ile 
        195                 200                 205             


Ala Val Val Gly Gly Ile Leu Tyr Gln Ser Ala Trp Ile Ile Ala Pro 
    210                 215                 220                 


Lys Leu Trp Ile Ile Gly Thr Ile Phe Pro Val Ala Gly Tyr Ser Leu 
225                 230                 235                 240 


Gly Phe Leu Leu Ala Arg Ile Ala Gly Leu Pro Trp Tyr Arg Cys Arg 
                245                 250                 255     


Thr Val Ala Phe Glu Thr Gly Met Gln Asn Thr Gln Leu Cys Ser Thr 
            260                 265                 270         


Ile Val Gln Leu Ser Phe Thr Pro Glu Glu Leu Asn Val Val Phe Thr 
        275                 280                 285             


Phe Pro Leu Ile Tyr Ser Ile Phe Gln Leu Ala Phe Ala Ala Ile Phe 
    290                 295                 300                 


Leu Gly Phe Tyr Val Ala Tyr Lys Lys Cys His Gly Lys Asn Lys Ala 
305                 310                 315                 320 


Glu Ile Pro Glu Ser Lys Glu Asn Gly Thr Glu Pro Glu Ser Ser Phe 
                325                 330                 335     


Tyr Lys Ala Asn Gly Gly Phe Gln Pro Asp Glu Lys 
            340                 345             


<210>  134
<211>  643
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Glu Ala Val Glu Thr Gly Glu Arg Pro Thr Phe Gly Ala Trp Asp 
1               5                   10                  15      


Tyr Gly Val Phe Ala Leu Met Leu Leu Val Ser Thr Gly Ile Gly Leu 
            20                  25                  30          


Trp Val Gly Leu Ala Arg Gly Gly Gln Arg Ser Ala Glu Asp Phe Phe 
        35                  40                  45              


Thr Gly Gly Arg Arg Leu Ala Ala Leu Pro Val Gly Leu Ser Leu Ser 
    50                  55                  60                  


Ala Ser Phe Met Ser Ala Val Gln Val Leu Gly Val Pro Ser Glu Ala 
65                  70                  75                  80  


Tyr Arg Tyr Gly Leu Lys Phe Leu Trp Met Cys Leu Gly Gln Leu Leu 
                85                  90                  95      


Asn Ser Val Leu Thr Ala Leu Leu Phe Met Pro Val Phe Tyr Arg Leu 
            100                 105                 110         


Gly Leu Thr Ser Thr Tyr Glu Tyr Leu Glu Met Arg Phe Ser Arg Ala 
        115                 120                 125             


Val Arg Leu Cys Gly Thr Leu Gln Tyr Ile Val Ala Thr Met Leu Tyr 
    130                 135                 140                 


Thr Gly Ile Val Ile Tyr Ala Pro Ala Leu Ile Leu Asn Gln Val Thr 
145                 150                 155                 160 


Gly Leu Asp Ile Trp Ala Ser Leu Leu Ser Thr Gly Ile Ile Cys Thr 
                165                 170                 175     


Phe Tyr Thr Ala Val Gly Gly Met Lys Ala Val Val Trp Thr Asp Val 
            180                 185                 190         


Phe Gln Val Val Val Met Leu Ser Gly Phe Trp Val Val Leu Ala Arg 
        195                 200                 205             


Gly Val Met Leu Val Gly Gly Pro Arg Gln Val Leu Thr Leu Ala Gln 
    210                 215                 220                 


Asn His Ser Arg Ile Asn Leu Met Asp Phe Asn Pro Asp Pro Arg Ser 
225                 230                 235                 240 


Arg Tyr Thr Phe Trp Thr Phe Val Val Gly Gly Thr Leu Val Trp Leu 
                245                 250                 255     


Ser Met Tyr Gly Val Asn Gln Ala Gln Val Gln Arg Tyr Val Ala Cys 
            260                 265                 270         


Arg Thr Glu Lys Gln Ala Lys Leu Ala Leu Leu Ile Asn Gln Val Gly 
        275                 280                 285             


Leu Phe Leu Ile Val Ser Ser Ala Ala Cys Cys Gly Ile Val Met Phe 
    290                 295                 300                 


Val Phe Tyr Thr Asp Cys Asp Pro Leu Leu Leu Gly Arg Ile Ser Ala 
305                 310                 315                 320 


Pro Asp Gln Tyr Met Pro Leu Leu Val Leu Asp Ile Phe Glu Asp Leu 
                325                 330                 335     


Pro Gly Val Pro Gly Leu Phe Leu Ala Cys Ala Tyr Ser Gly Thr Leu 
            340                 345                 350         


Ser Thr Ala Ser Thr Ser Ile Asn Ala Met Ala Ala Val Thr Val Glu 
        355                 360                 365             


Asp Leu Ile Lys Pro Arg Leu Arg Ser Leu Ala Pro Arg Lys Leu Val 
    370                 375                 380                 


Ile Ile Ser Lys Gly Leu Ser Leu Ile Tyr Gly Ser Ala Cys Leu Thr 
385                 390                 395                 400 


Val Ala Ala Leu Ser Ser Leu Leu Gly Gly Gly Val Leu Gln Gly Ser 
                405                 410                 415     


Phe Thr Val Met Gly Val Ile Ser Gly Pro Leu Leu Gly Ala Phe Ile 
            420                 425                 430         


Leu Gly Met Phe Leu Pro Ala Cys Asn Thr Pro Gly Val Leu Ala Gly 
        435                 440                 445             


Leu Gly Ala Gly Leu Ala Leu Ser Leu Trp Val Ala Leu Gly Ala Thr 
    450                 455                 460                 


Leu Tyr Pro Pro Ser Glu Gln Thr Met Arg Val Leu Pro Ser Ser Ala 
465                 470                 475                 480 


Ala Arg Cys Val Ala Leu Ser Val Asn Ala Ser Gly Leu Leu Asp Pro 
                485                 490                 495     


Ala Leu Leu Pro Ala Asn Asp Ser Ser Arg Ala Pro Ser Ser Gly Met 
            500                 505                 510         


Asp Ala Ser Arg Pro Ala Leu Ala Asp Ser Phe Tyr Ala Ile Ser Tyr 
        515                 520                 525             


Leu Tyr Tyr Gly Ala Leu Gly Thr Leu Thr Thr Val Leu Cys Gly Ala 
    530                 535                 540                 


Leu Ile Ser Cys Leu Thr Gly Pro Thr Lys Arg Ser Thr Leu Ala Pro 
545                 550                 555                 560 


Gly Leu Leu Trp Trp Asp Leu Ala Arg Gln Thr Ala Ser Val Ala Pro 
                565                 570                 575     


Lys Glu Glu Val Ala Ile Leu Asp Asp Asn Leu Val Lys Gly Pro Glu 
            580                 585                 590         


Glu Leu Pro Thr Gly Asn Lys Lys Pro Pro Gly Phe Leu Pro Thr Asn 
        595                 600                 605             


Glu Asp Arg Leu Phe Phe Leu Gly Gln Lys Glu Leu Glu Gly Ala Gly 
    610                 615                 620                 


Ser Trp Thr Pro Cys Val Gly His Asp Gly Gly Arg Asp Gln Gln Glu 
625                 630                 635                 640 


Thr Asn Leu 
            


<210>  135
<211>  1124
<212>  PRT
<213>  Homo sapiens

<400>  135

Met Asp Ser Leu Ala Ser Leu Val Leu Cys Gly Val Ser Leu Leu Leu 
1               5                   10                  15      


Ser Gly Thr Val Glu Gly Ala Met Asp Leu Ile Leu Ile Asn Ser Leu 
            20                  25                  30          


Pro Leu Val Ser Asp Ala Glu Thr Ser Leu Thr Cys Ile Ala Ser Gly 
        35                  40                  45              


Trp Arg Pro His Glu Pro Ile Thr Ile Gly Arg Asp Phe Glu Ala Leu 
    50                  55                  60                  


Met Asn Gln His Gln Asp Pro Leu Glu Val Thr Gln Asp Val Thr Arg 
65                  70                  75                  80  


Glu Trp Ala Lys Lys Val Val Trp Lys Arg Glu Lys Ala Ser Lys Ile 
                85                  90                  95      


Asn Gly Ala Tyr Phe Cys Glu Gly Arg Val Arg Gly Glu Ala Ile Arg 
            100                 105                 110         


Ile Arg Thr Met Lys Met Arg Gln Gln Ala Ser Phe Leu Pro Ala Thr 
        115                 120                 125             


Leu Thr Met Thr Val Asp Lys Gly Asp Asn Val Asn Ile Ser Phe Lys 
    130                 135                 140                 


Lys Val Leu Ile Lys Glu Glu Asp Ala Val Ile Tyr Lys Asn Gly Ser 
145                 150                 155                 160 


Phe Ile His Ser Val Pro Arg His Glu Val Pro Asp Ile Leu Glu Val 
                165                 170                 175     


His Leu Pro His Ala Gln Pro Gln Asp Ala Gly Val Tyr Ser Ala Arg 
            180                 185                 190         


Tyr Ile Gly Gly Asn Leu Phe Thr Ser Ala Phe Thr Arg Leu Ile Val 
        195                 200                 205             


Arg Arg Cys Glu Ala Gln Lys Trp Gly Pro Glu Cys Asn His Leu Cys 
    210                 215                 220                 


Thr Ala Cys Met Asn Asn Gly Val Cys His Glu Asp Thr Gly Glu Cys 
225                 230                 235                 240 


Ile Cys Pro Pro Gly Phe Met Gly Arg Thr Cys Glu Lys Ala Cys Glu 
                245                 250                 255     


Leu His Thr Phe Gly Arg Thr Cys Lys Glu Arg Cys Ser Gly Gln Glu 
            260                 265                 270         


Gly Cys Lys Ser Tyr Val Phe Cys Leu Pro Asp Pro Tyr Gly Cys Ser 
        275                 280                 285             


Cys Ala Thr Gly Trp Lys Gly Leu Gln Cys Asn Glu Ala Cys His Pro 
    290                 295                 300                 


Gly Phe Tyr Gly Pro Asp Cys Lys Leu Arg Cys Ser Cys Asn Asn Gly 
305                 310                 315                 320 


Glu Met Cys Asp Arg Phe Gln Gly Cys Leu Cys Ser Pro Gly Trp Gln 
                325                 330                 335     


Gly Leu Gln Cys Glu Arg Glu Gly Ile Pro Arg Met Thr Pro Lys Ile 
            340                 345                 350         


Val Asp Leu Pro Asp His Ile Glu Val Asn Ser Gly Lys Phe Asn Pro 
        355                 360                 365             


Ile Cys Lys Ala Ser Gly Trp Pro Leu Pro Thr Asn Glu Glu Met Thr 
    370                 375                 380                 


Leu Val Lys Pro Asp Gly Thr Val Leu His Pro Lys Asp Phe Asn His 
385                 390                 395                 400 


Thr Asp His Phe Ser Val Ala Ile Phe Thr Ile His Arg Ile Leu Pro 
                405                 410                 415     


Pro Asp Ser Gly Val Trp Val Cys Ser Val Asn Thr Val Ala Gly Met 
            420                 425                 430         


Val Glu Lys Pro Phe Asn Ile Ser Val Lys Val Leu Pro Lys Pro Leu 
        435                 440                 445             


Asn Ala Pro Asn Val Ile Asp Thr Gly His Asn Phe Ala Val Ile Asn 
    450                 455                 460                 


Ile Ser Ser Glu Pro Tyr Phe Gly Asp Gly Pro Ile Lys Ser Lys Lys 
465                 470                 475                 480 


Leu Leu Tyr Lys Pro Val Asn His Tyr Glu Ala Trp Gln His Ile Gln 
                485                 490                 495     


Val Thr Asn Glu Ile Val Thr Leu Asn Tyr Leu Glu Pro Arg Thr Glu 
            500                 505                 510         


Tyr Glu Leu Cys Val Gln Leu Val Arg Arg Gly Glu Gly Gly Glu Gly 
        515                 520                 525             


His Pro Gly Pro Val Arg Arg Phe Thr Thr Ala Ser Ile Gly Leu Pro 
    530                 535                 540                 


Pro Pro Arg Gly Leu Asn Leu Leu Pro Lys Ser Gln Thr Thr Leu Asn 
545                 550                 555                 560 


Leu Thr Trp Gln Pro Ile Phe Pro Ser Ser Glu Asp Asp Phe Tyr Val 
                565                 570                 575     


Glu Val Glu Arg Arg Ser Val Gln Lys Ser Asp Gln Gln Asn Ile Lys 
            580                 585                 590         


Val Pro Gly Asn Leu Thr Ser Val Leu Leu Asn Asn Leu His Pro Arg 
        595                 600                 605             


Glu Gln Tyr Val Val Arg Ala Arg Val Asn Thr Lys Ala Gln Gly Glu 
    610                 615                 620                 


Trp Ser Glu Asp Leu Thr Ala Trp Thr Leu Ser Asp Ile Leu Pro Pro 
625                 630                 635                 640 


Gln Pro Glu Asn Ile Lys Ile Ser Asn Ile Thr His Ser Ser Ala Val 
                645                 650                 655     


Ile Ser Trp Thr Ile Leu Asp Gly Tyr Ser Ile Ser Ser Ile Thr Ile 
            660                 665                 670         


Arg Tyr Lys Val Gln Gly Lys Asn Glu Asp Gln His Val Asp Val Lys 
        675                 680                 685             


Ile Lys Asn Ala Thr Ile Thr Gln Tyr Gln Leu Lys Gly Leu Glu Pro 
    690                 695                 700                 


Glu Thr Ala Tyr Gln Val Asp Ile Phe Ala Glu Asn Asn Ile Gly Ser 
705                 710                 715                 720 


Ser Asn Pro Ala Phe Ser His Glu Leu Val Thr Leu Pro Glu Ser Gln 
                725                 730                 735     


Ala Pro Ala Asp Leu Gly Gly Gly Lys Met Leu Leu Ile Ala Ile Leu 
            740                 745                 750         


Gly Ser Ala Gly Met Thr Cys Leu Thr Val Leu Leu Ala Phe Leu Ile 
        755                 760                 765             


Ile Leu Gln Leu Lys Arg Ala Asn Val Gln Arg Arg Met Ala Gln Ala 
    770                 775                 780                 


Phe Gln Asn Val Arg Glu Glu Pro Ala Val Gln Phe Asn Ser Gly Thr 
785                 790                 795                 800 


Leu Ala Leu Asn Arg Lys Val Lys Asn Asn Pro Asp Pro Thr Ile Tyr 
                805                 810                 815     


Pro Val Leu Asp Trp Asn Asp Ile Lys Phe Gln Asp Val Ile Gly Glu 
            820                 825                 830         


Gly Asn Phe Gly Gln Val Leu Lys Ala Arg Ile Lys Lys Asp Gly Leu 
        835                 840                 845             


Arg Met Asp Ala Ala Ile Lys Arg Met Lys Glu Tyr Ala Ser Lys Asp 
    850                 855                 860                 


Asp His Arg Asp Phe Ala Gly Glu Leu Glu Val Leu Cys Lys Leu Gly 
865                 870                 875                 880 


His His Pro Asn Ile Ile Asn Leu Leu Gly Ala Cys Glu His Arg Gly 
                885                 890                 895     


Tyr Leu Tyr Leu Ala Ile Glu Tyr Ala Pro His Gly Asn Leu Leu Asp 
            900                 905                 910         


Phe Leu Arg Lys Ser Arg Val Leu Glu Thr Asp Pro Ala Phe Ala Ile 
        915                 920                 925             


Ala Asn Ser Thr Ala Ser Thr Leu Ser Ser Gln Gln Leu Leu His Phe 
    930                 935                 940                 


Ala Ala Asp Val Ala Arg Gly Met Asp Tyr Leu Ser Gln Lys Gln Phe 
945                 950                 955                 960 


Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Gly Glu Asn Tyr 
                965                 970                 975     


Val Ala Lys Ile Ala Asp Phe Gly Leu Ser Arg Gly Gln Glu Val Tyr 
            980                 985                 990         


Val Lys Lys Thr Met Gly Arg Leu  Pro Val Arg Trp Met  Ala Ile Glu 
        995                 1000                 1005             


Ser Leu  Asn Tyr Ser Val Tyr  Thr Thr Asn Ser Asp  Val Trp Ser 
    1010                 1015                 1020             


Tyr Gly  Val Leu Leu Trp Glu  Ile Val Ser Leu Gly  Gly Thr Pro 
    1025                 1030                 1035             


Tyr Cys  Gly Met Thr Cys Ala  Glu Leu Tyr Glu Lys  Leu Pro Gln 
    1040                 1045                 1050             


Gly Tyr  Arg Leu Glu Lys Pro  Leu Asn Cys Asp Asp  Glu Val Tyr 
    1055                 1060                 1065             


Asp Leu  Met Arg Gln Cys Trp  Arg Glu Lys Pro Tyr  Glu Arg Pro 
    1070                 1075                 1080             


Ser Phe  Ala Gln Ile Leu Val  Ser Leu Asn Arg Met  Leu Glu Glu 
    1085                 1090                 1095             


Arg Lys  Thr Tyr Val Asn Thr  Thr Leu Tyr Glu Lys  Phe Thr Tyr 
    1100                 1105                 1110             


Ala Gly  Ile Asp Cys Ser Ala  Glu Glu Ala Ala 
    1115                 1120                 


<210>  136
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  136

Met Ala Val Glu Ser Gln Gly Gly Arg Pro Leu Val Leu Gly Leu Leu 
1               5                   10                  15      


Leu Cys Val Leu Gly Pro Val Val Ser His Ala Gly Lys Ile Leu Leu 
            20                  25                  30          


Ile Pro Val Asp Gly Ser His Trp Leu Ser Met Leu Gly Ala Ile Gln 
        35                  40                  45              


Gln Leu Gln Gln Arg Gly His Glu Ile Val Val Leu Ala Pro Asp Ala 
    50                  55                  60                  


Ser Leu Tyr Ile Arg Asp Gly Ala Phe Tyr Thr Leu Lys Thr Tyr Pro 
65                  70                  75                  80  


Val Pro Phe Gln Arg Glu Asp Val Lys Glu Ser Phe Val Ser Leu Gly 
                85                  90                  95      


His Asn Val Phe Glu Asn Asp Ser Phe Leu Gln Arg Val Ile Lys Thr 
            100                 105                 110         


Tyr Lys Lys Ile Lys Lys Asp Ser Ala Met Leu Leu Ser Gly Cys Ser 
        115                 120                 125             


His Leu Leu His Asn Lys Glu Leu Met Ala Ser Leu Ala Glu Ser Ser 
    130                 135                 140                 


Phe Asp Val Met Leu Thr Asp Pro Phe Leu Pro Cys Ser Pro Ile Val 
145                 150                 155                 160 


Ala Gln Tyr Leu Ser Leu Pro Thr Val Phe Phe Leu His Ala Leu Pro 
                165                 170                 175     


Cys Ser Leu Glu Phe Glu Ala Thr Gln Cys Pro Asn Pro Phe Ser Tyr 
            180                 185                 190         


Val Pro Arg Pro Leu Ser Ser His Ser Asp His Met Thr Phe Leu Gln 
        195                 200                 205             


Arg Val Lys Asn Met Leu Ile Ala Phe Ser Gln Asn Phe Leu Cys Asp 
    210                 215                 220                 


Val Val Tyr Ser Pro Tyr Ala Thr Leu Ala Ser Glu Phe Leu Gln Arg 
225                 230                 235                 240 


Glu Val Thr Val Gln Asp Leu Leu Ser Ser Ala Ser Val Trp Leu Phe 
                245                 250                 255     


Arg Ser Asp Phe Val Lys Asp Tyr Pro Arg Pro Ile Met Pro Asn Met 
            260                 265                 270         


Val Phe Val Gly Gly Ile Asn Cys Leu His Gln Asn Pro Leu Ser Gln 
        275                 280                 285             


Glu Phe Glu Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val Val 
    290                 295                 300                 


Phe Ser Leu Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala Met 
305                 310                 315                 320 


Ala Ile Ala Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp Arg 
                325                 330                 335     


Tyr Thr Gly Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu Val 
            340                 345                 350         


Lys Trp Leu Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg Ala 
        355                 360                 365             


Phe Ile Thr His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys Asn 
    370                 375                 380                 


Gly Val Pro Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp Asn 
385                 390                 395                 400 


Ala Lys Arg Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val Leu 
                405                 410                 415     


Glu Met Thr Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile Asn 
            420                 425                 430         


Asp Lys Ser Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His Lys 
        435                 440                 445             


Asp Arg Pro Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu Phe 
    450                 455                 460                 


Val Met Arg His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His Asp 
465                 470                 475                 480 


Leu Thr Trp Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu Leu 
                485                 490                 495     


Ala Val Val Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala Tyr 
            500                 505                 510         


Gly Tyr Arg Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala His 
        515                 520                 525             


Lys Ser Lys Thr His 
    530             


<210>  137
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  137

Met Trp Glu Leu Arg Ser Ile Ala Phe Ser Arg Ala Val Phe Ala Glu 
1               5                   10                  15      


Phe Leu Ala Thr Leu Leu Phe Val Phe Phe Gly Leu Gly Ser Ala Leu 
            20                  25                  30          


Asn Trp Pro Gln Ala Leu Pro Ser Val Leu Gln Ile Ala Met Ala Phe 
        35                  40                  45              


Gly Leu Gly Ile Gly Thr Leu Val Gln Ala Leu Gly His Ile Ser Gly 
    50                  55                  60                  


Ala His Ile Asn Pro Ala Val Thr Val Ala Cys Leu Val Gly Cys His 
65                  70                  75                  80  


Val Ser Val Leu Arg Ala Ala Phe Tyr Val Ala Ala Gln Leu Leu Gly 
                85                  90                  95      


Ala Val Ala Gly Ala Ala Leu Leu His Glu Ile Thr Pro Ala Asp Ile 
            100                 105                 110         


Arg Gly Asp Leu Ala Val Asn Ala Leu Ser Asn Ser Thr Thr Ala Gly 
        115                 120                 125             


Gln Ala Val Thr Val Glu Leu Phe Leu Thr Leu Gln Leu Val Leu Cys 
    130                 135                 140                 


Ile Phe Ala Ser Thr Asp Glu Arg Arg Gly Glu Asn Pro Gly Thr Pro 
145                 150                 155                 160 


Ala Leu Ser Ile Gly Phe Ser Val Ala Leu Gly His Leu Leu Gly Ile 
                165                 170                 175     


His Tyr Thr Gly Cys Ser Met Asn Pro Ala Arg Ser Leu Ala Pro Ala 
            180                 185                 190         


Val Val Thr Gly Lys Phe Asp Asp His Trp Val Phe Trp Ile Gly Pro 
        195                 200                 205             


Leu Val Gly Ala Ile Leu Gly Ser Leu Leu Tyr Asn Tyr Val Leu Phe 
    210                 215                 220                 


Pro Pro Ala Lys Ser Leu Ser Glu Arg Leu Ala Val Leu Lys Gly Leu 
225                 230                 235                 240 


Glu Pro Asp Thr Asp Trp Glu Glu Arg Glu Val Arg Arg Arg Gln Ser 
                245                 250                 255     


Val Glu Leu His Ser Pro Gln Ser Leu Pro Arg Gly Thr Lys Ala 
            260                 265                 270     


<210>  138
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  138

Met Met Met Lys Ile Pro Trp Gly Ser Ile Pro Val Leu Met Leu Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Ile Asp Ile Ser Gln Ala Gln Leu Ser Cys Thr 
            20                  25                  30          


Gly Pro Pro Ala Ile Pro Gly Ile Pro Gly Ile Pro Gly Thr Pro Gly 
        35                  40                  45              


Pro Asp Gly Gln Pro Gly Thr Pro Gly Ile Lys Gly Glu Lys Gly Leu 
    50                  55                  60                  


Pro Gly Leu Ala Gly Asp His Gly Glu Phe Gly Glu Lys Gly Asp Pro 
65                  70                  75                  80  


Gly Ile Pro Gly Asn Pro Gly Lys Val Gly Pro Lys Gly Pro Met Gly 
                85                  90                  95      


Pro Lys Gly Gly Pro Gly Ala Pro Gly Ala Pro Gly Pro Lys Gly Glu 
            100                 105                 110         


Ser Gly Asp Tyr Lys Ala Thr Gln Lys Ile Ala Phe Ser Ala Thr Arg 
        115                 120                 125             


Thr Ile Asn Val Pro Leu Arg Arg Asp Gln Thr Ile Arg Phe Asp His 
    130                 135                 140                 


Val Ile Thr Asn Met Asn Asn Asn Tyr Glu Pro Arg Ser Gly Lys Phe 
145                 150                 155                 160 


Thr Cys Lys Val Pro Gly Leu Tyr Tyr Phe Thr Tyr His Ala Ser Ser 
                165                 170                 175     


Arg Gly Asn Leu Cys Val Asn Leu Met Arg Gly Arg Glu Arg Ala Gln 
            180                 185                 190         


Lys Val Val Thr Phe Cys Asp Tyr Ala Tyr Asn Thr Phe Gln Val Thr 
        195                 200                 205             


Thr Gly Gly Met Val Leu Lys Leu Glu Gln Gly Glu Asn Val Phe Leu 
    210                 215                 220                 


Gln Ala Thr Asp Lys Asn Ser Leu Leu Gly Met Glu Gly Ala Asn Ser 
225                 230                 235                 240 


Ile Phe Ser Gly Phe Leu Leu Phe Pro Asp Met Glu Ala 
                245                 250             


<210>  139
<211>  1480
<212>  PRT
<213>  Homo sapiens

<400>  139

Met Gln Arg Ser Pro Leu Glu Lys Ala Ser Val Val Ser Lys Leu Phe 
1               5                   10                  15      


Phe Ser Trp Thr Arg Pro Ile Leu Arg Lys Gly Tyr Arg Gln Arg Leu 
            20                  25                  30          


Glu Leu Ser Asp Ile Tyr Gln Ile Pro Ser Val Asp Ser Ala Asp Asn 
        35                  40                  45              


Leu Ser Glu Lys Leu Glu Arg Glu Trp Asp Arg Glu Leu Ala Ser Lys 
    50                  55                  60                  


Lys Asn Pro Lys Leu Ile Asn Ala Leu Arg Arg Cys Phe Phe Trp Arg 
65                  70                  75                  80  


Phe Met Phe Tyr Gly Ile Phe Leu Tyr Leu Gly Glu Val Thr Lys Ala 
                85                  90                  95      


Val Gln Pro Leu Leu Leu Gly Arg Ile Ile Ala Ser Tyr Asp Pro Asp 
            100                 105                 110         


Asn Lys Glu Glu Arg Ser Ile Ala Ile Tyr Leu Gly Ile Gly Leu Cys 
        115                 120                 125             


Leu Leu Phe Ile Val Arg Thr Leu Leu Leu His Pro Ala Ile Phe Gly 
    130                 135                 140                 


Leu His His Ile Gly Met Gln Met Arg Ile Ala Met Phe Ser Leu Ile 
145                 150                 155                 160 


Tyr Lys Lys Thr Leu Lys Leu Ser Ser Arg Val Leu Asp Lys Ile Ser 
                165                 170                 175     


Ile Gly Gln Leu Val Ser Leu Leu Ser Asn Asn Leu Asn Lys Phe Asp 
            180                 185                 190         


Glu Gly Leu Ala Leu Ala His Phe Val Trp Ile Ala Pro Leu Gln Val 
        195                 200                 205             


Ala Leu Leu Met Gly Leu Ile Trp Glu Leu Leu Gln Ala Ser Ala Phe 
    210                 215                 220                 


Cys Gly Leu Gly Phe Leu Ile Val Leu Ala Leu Phe Gln Ala Gly Leu 
225                 230                 235                 240 


Gly Arg Met Met Met Lys Tyr Arg Asp Gln Arg Ala Gly Lys Ile Ser 
                245                 250                 255     


Glu Arg Leu Val Ile Thr Ser Glu Met Ile Glu Asn Ile Gln Ser Val 
            260                 265                 270         


Lys Ala Tyr Cys Trp Glu Glu Ala Met Glu Lys Met Ile Glu Asn Leu 
        275                 280                 285             


Arg Gln Thr Glu Leu Lys Leu Thr Arg Lys Ala Ala Tyr Val Arg Tyr 
    290                 295                 300                 


Phe Asn Ser Ser Ala Phe Phe Phe Ser Gly Phe Phe Val Val Phe Leu 
305                 310                 315                 320 


Ser Val Leu Pro Tyr Ala Leu Ile Lys Gly Ile Ile Leu Arg Lys Ile 
                325                 330                 335     


Phe Thr Thr Ile Ser Phe Cys Ile Val Leu Arg Met Ala Val Thr Arg 
            340                 345                 350         


Gln Phe Pro Trp Ala Val Gln Thr Trp Tyr Asp Ser Leu Gly Ala Ile 
        355                 360                 365             


Asn Lys Ile Gln Asp Phe Leu Gln Lys Gln Glu Tyr Lys Thr Leu Glu 
    370                 375                 380                 


Tyr Asn Leu Thr Thr Thr Glu Val Val Met Glu Asn Val Thr Ala Phe 
385                 390                 395                 400 


Trp Glu Glu Gly Phe Gly Glu Leu Phe Glu Lys Ala Lys Gln Asn Asn 
                405                 410                 415     


Asn Asn Arg Lys Thr Ser Asn Gly Asp Asp Ser Leu Phe Phe Ser Asn 
            420                 425                 430         


Phe Ser Leu Leu Gly Thr Pro Val Leu Lys Asp Ile Asn Phe Lys Ile 
        435                 440                 445             


Glu Arg Gly Gln Leu Leu Ala Val Ala Gly Ser Thr Gly Ala Gly Lys 
    450                 455                 460                 


Thr Ser Leu Leu Met Val Ile Met Gly Glu Leu Glu Pro Ser Glu Gly 
465                 470                 475                 480 


Lys Ile Lys His Ser Gly Arg Ile Ser Phe Cys Ser Gln Phe Ser Trp 
                485                 490                 495     


Ile Met Pro Gly Thr Ile Lys Glu Asn Ile Ile Phe Gly Val Ser Tyr 
            500                 505                 510         


Asp Glu Tyr Arg Tyr Arg Ser Val Ile Lys Ala Cys Gln Leu Glu Glu 
        515                 520                 525             


Asp Ile Ser Lys Phe Ala Glu Lys Asp Asn Ile Val Leu Gly Glu Gly 
    530                 535                 540                 


Gly Ile Thr Leu Ser Gly Gly Gln Arg Ala Arg Ile Ser Leu Ala Arg 
545                 550                 555                 560 


Ala Val Tyr Lys Asp Ala Asp Leu Tyr Leu Leu Asp Ser Pro Phe Gly 
                565                 570                 575     


Tyr Leu Asp Val Leu Thr Glu Lys Glu Ile Phe Glu Ser Cys Val Cys 
            580                 585                 590         


Lys Leu Met Ala Asn Lys Thr Arg Ile Leu Val Thr Ser Lys Met Glu 
        595                 600                 605             


His Leu Lys Lys Ala Asp Lys Ile Leu Ile Leu His Glu Gly Ser Ser 
    610                 615                 620                 


Tyr Phe Tyr Gly Thr Phe Ser Glu Leu Gln Asn Leu Gln Pro Asp Phe 
625                 630                 635                 640 


Ser Ser Lys Leu Met Gly Cys Asp Ser Phe Asp Gln Phe Ser Ala Glu 
                645                 650                 655     


Arg Arg Asn Ser Ile Leu Thr Glu Thr Leu His Arg Phe Ser Leu Glu 
            660                 665                 670         


Gly Asp Ala Pro Val Ser Trp Thr Glu Thr Lys Lys Gln Ser Phe Lys 
        675                 680                 685             


Gln Thr Gly Glu Phe Gly Glu Lys Arg Lys Asn Ser Ile Leu Asn Pro 
    690                 695                 700                 


Ile Asn Ser Ile Arg Lys Phe Ser Ile Val Gln Lys Thr Pro Leu Gln 
705                 710                 715                 720 


Met Asn Gly Ile Glu Glu Asp Ser Asp Glu Pro Leu Glu Arg Arg Leu 
                725                 730                 735     


Ser Leu Val Pro Asp Ser Glu Gln Gly Glu Ala Ile Leu Pro Arg Ile 
            740                 745                 750         


Ser Val Ile Ser Thr Gly Pro Thr Leu Gln Ala Arg Arg Arg Gln Ser 
        755                 760                 765             


Val Leu Asn Leu Met Thr His Ser Val Asn Gln Gly Gln Asn Ile His 
    770                 775                 780                 


Arg Lys Thr Thr Ala Ser Thr Arg Lys Val Ser Leu Ala Pro Gln Ala 
785                 790                 795                 800 


Asn Leu Thr Glu Leu Asp Ile Tyr Ser Arg Arg Leu Ser Gln Glu Thr 
                805                 810                 815     


Gly Leu Glu Ile Ser Glu Glu Ile Asn Glu Glu Asp Leu Lys Glu Cys 
            820                 825                 830         


Phe Phe Asp Asp Met Glu Ser Ile Pro Ala Val Thr Thr Trp Asn Thr 
        835                 840                 845             


Tyr Leu Arg Tyr Ile Thr Val His Lys Ser Leu Ile Phe Val Leu Ile 
    850                 855                 860                 


Trp Cys Leu Val Ile Phe Leu Ala Glu Val Ala Ala Ser Leu Val Val 
865                 870                 875                 880 


Leu Trp Leu Leu Gly Asn Thr Pro Leu Gln Asp Lys Gly Asn Ser Thr 
                885                 890                 895     


His Ser Arg Asn Asn Ser Tyr Ala Val Ile Ile Thr Ser Thr Ser Ser 
            900                 905                 910         


Tyr Tyr Val Phe Tyr Ile Tyr Val Gly Val Ala Asp Thr Leu Leu Ala 
        915                 920                 925             


Met Gly Phe Phe Arg Gly Leu Pro Leu Val His Thr Leu Ile Thr Val 
    930                 935                 940                 


Ser Lys Ile Leu His His Lys Met Leu His Ser Val Leu Gln Ala Pro 
945                 950                 955                 960 


Met Ser Thr Leu Asn Thr Leu Lys Ala Gly Gly Ile Leu Asn Arg Phe 
                965                 970                 975     


Ser Lys Asp Ile Ala Ile Leu Asp Asp Leu Leu Pro Leu Thr Ile Phe 
            980                 985                 990         


Asp Phe Ile Gln Leu Leu Leu Ile  Val Ile Gly Ala Ile  Ala Val Val 
        995                 1000                 1005             


Ala Val  Leu Gln Pro Tyr Ile  Phe Val Ala Thr Val  Pro Val Ile 
    1010                 1015                 1020             


Val Ala  Phe Ile Met Leu Arg  Ala Tyr Phe Leu Gln  Thr Ser Gln 
    1025                 1030                 1035             


Gln Leu  Lys Gln Leu Glu Ser  Glu Gly Arg Ser Pro  Ile Phe Thr 
    1040                 1045                 1050             


His Leu  Val Thr Ser Leu Lys  Gly Leu Trp Thr Leu  Arg Ala Phe 
    1055                 1060                 1065             


Gly Arg  Gln Pro Tyr Phe Glu  Thr Leu Phe His Lys  Ala Leu Asn 
    1070                 1075                 1080             


Leu His  Thr Ala Asn Trp Phe  Leu Tyr Leu Ser Thr  Leu Arg Trp 
    1085                 1090                 1095             


Phe Gln  Met Arg Ile Glu Met  Ile Phe Val Ile Phe  Phe Ile Ala 
    1100                 1105                 1110             


Val Thr  Phe Ile Ser Ile Leu  Thr Thr Gly Glu Gly  Glu Gly Arg 
    1115                 1120                 1125             


Val Gly  Ile Ile Leu Thr Leu  Ala Met Asn Ile Met  Ser Thr Leu 
    1130                 1135                 1140             


Gln Trp  Ala Val Asn Ser Ser  Ile Asp Val Asp Ser  Leu Met Arg 
    1145                 1150                 1155             


Ser Val  Ser Arg Val Phe Lys  Phe Ile Asp Met Pro  Thr Glu Gly 
    1160                 1165                 1170             


Lys Pro  Thr Lys Ser Thr Lys  Pro Tyr Lys Asn Gly  Gln Leu Ser 
    1175                 1180                 1185             


Lys Val  Met Ile Ile Glu Asn  Ser His Val Lys Lys  Asp Asp Ile 
    1190                 1195                 1200             


Trp Pro  Ser Gly Gly Gln Met  Thr Val Lys Asp Leu  Thr Ala Lys 
    1205                 1210                 1215             


Tyr Thr  Glu Gly Gly Asn Ala  Ile Leu Glu Asn Ile  Ser Phe Ser 
    1220                 1225                 1230             


Ile Ser  Pro Gly Gln Arg Val  Gly Leu Leu Gly Arg  Thr Gly Ser 
    1235                 1240                 1245             


Gly Lys  Ser Thr Leu Leu Ser  Ala Phe Leu Arg Leu  Leu Asn Thr 
    1250                 1255                 1260             


Glu Gly  Glu Ile Gln Ile Asp  Gly Val Ser Trp Asp  Ser Ile Thr 
    1265                 1270                 1275             


Leu Gln  Gln Trp Arg Lys Ala  Phe Gly Val Ile Pro  Gln Lys Val 
    1280                 1285                 1290             


Phe Ile  Phe Ser Gly Thr Phe  Arg Lys Asn Leu Asp  Pro Tyr Glu 
    1295                 1300                 1305             


Gln Trp  Ser Asp Gln Glu Ile  Trp Lys Val Ala Asp  Glu Val Gly 
    1310                 1315                 1320             


Leu Arg  Ser Val Ile Glu Gln  Phe Pro Gly Lys Leu  Asp Phe Val 
    1325                 1330                 1335             


Leu Val  Asp Gly Gly Cys Val  Leu Ser His Gly His  Lys Gln Leu 
    1340                 1345                 1350             


Met Cys  Leu Ala Arg Ser Val  Leu Ser Lys Ala Lys  Ile Leu Leu 
    1355                 1360                 1365             


Leu Asp  Glu Pro Ser Ala His  Leu Asp Pro Val Thr  Tyr Gln Ile 
    1370                 1375                 1380             


Ile Arg  Arg Thr Leu Lys Gln  Ala Phe Ala Asp Cys  Thr Val Ile 
    1385                 1390                 1395             


Leu Cys  Glu His Arg Ile Glu  Ala Met Leu Glu Cys  Gln Gln Phe 
    1400                 1405                 1410             


Leu Val  Ile Glu Glu Asn Lys  Val Arg Gln Tyr Asp  Ser Ile Gln 
    1415                 1420                 1425             


Lys Leu  Leu Asn Glu Arg Ser  Leu Phe Arg Gln Ala  Ile Ser Pro 
    1430                 1435                 1440             


Ser Asp  Arg Val Lys Leu Phe  Pro His Arg Asn Ser  Ser Lys Cys 
    1445                 1450                 1455             


Lys Ser  Lys Pro Gln Ile Ala  Ala Leu Lys Glu Glu  Thr Glu Glu 
    1460                 1465                 1470             


Glu Val  Gln Asp Thr Arg Leu  
    1475                 1480 


<210>  140
<211>  1497
<212>  PRT
<213>  Homo sapiens

<400>  140

Met Asp Val Thr Lys Lys Asn Lys Arg Asp Gly Thr Glu Val Thr Glu 
1               5                   10                  15      


Arg Ile Val Thr Glu Thr Val Thr Thr Arg Leu Thr Ser Leu Pro Pro 
            20                  25                  30          


Lys Gly Gly Thr Ser Asn Gly Tyr Ala Lys Thr Ala Ser Leu Gly Gly 
        35                  40                  45              


Gly Ser Arg Leu Glu Lys Gln Ser Leu Thr His Gly Ser Ser Gly Tyr 
    50                  55                  60                  


Ile Asn Ser Thr Gly Ser Thr Arg Gly His Ala Ser Thr Ser Ser Tyr 
65                  70                  75                  80  


Arg Arg Ala His Ser Pro Ala Ser Thr Leu Pro Asn Ser Pro Gly Ser 
                85                  90                  95      


Thr Phe Glu Arg Lys Thr His Val Thr Arg His Ala Tyr Glu Gly Ser 
            100                 105                 110         


Ser Ser Gly Asn Ser Ser Pro Glu Tyr Pro Arg Lys Glu Phe Ala Ser 
        115                 120                 125             


Ser Ser Thr Arg Gly Arg Ser Gln Thr Arg Glu Ser Glu Ile Arg Val 
    130                 135                 140                 


Arg Leu Gln Ser Ala Ser Pro Ser Thr Arg Trp Thr Glu Leu Asp Asp 
145                 150                 155                 160 


Val Lys Arg Leu Leu Lys Gly Ser Arg Ser Ala Ser Val Ser Pro Thr 
                165                 170                 175     


Arg Asn Ser Ser Asn Thr Leu Pro Ile Pro Lys Lys Gly Thr Val Glu 
            180                 185                 190         


Thr Lys Ile Val Thr Ala Ser Ser Gln Ser Val Ser Gly Thr Tyr Asp 
        195                 200                 205             


Ala Thr Ile Leu Asp Ala Asn Leu Pro Ser His Val Trp Ser Ser Thr 
    210                 215                 220                 


Leu Pro Ala Gly Ser Ser Met Gly Thr Tyr His Asn Asn Met Thr Thr 
225                 230                 235                 240 


Gln Ser Ser Ser Leu Leu Asn Thr Asn Ala Tyr Ser Ala Gly Ser Val 
                245                 250                 255     


Phe Gly Val Pro Asn Asn Met Ala Ser Cys Ser Pro Thr Leu His Pro 
            260                 265                 270         


Gly Leu Ser Thr Ser Ser Ser Val Phe Gly Met Gln Asn Asn Leu Ala 
        275                 280                 285             


Pro Ser Leu Thr Thr Leu Ser His Gly Thr Thr Thr Thr Ser Thr Ala 
    290                 295                 300                 


Tyr Gly Val Lys Lys Asn Met Pro Gln Ser Pro Ala Ala Val Asn Thr 
305                 310                 315                 320 


Gly Val Ser Thr Ser Ala Ala Cys Thr Thr Ser Val Gln Ser Asp Asp 
                325                 330                 335     


Leu Leu His Lys Asp Cys Lys Phe Leu Ile Leu Glu Lys Asp Asn Thr 
            340                 345                 350         


Pro Ala Lys Lys Glu Met Glu Leu Leu Ile Met Thr Lys Asp Ser Gly 
        355                 360                 365             


Lys Val Phe Thr Ala Ser Pro Ala Ser Ile Ala Ala Thr Ser Phe Ser 
    370                 375                 380                 


Glu Asp Thr Leu Lys Lys Glu Lys Gln Ala Ala Tyr Asn Ala Asp Ser 
385                 390                 395                 400 


Gly Leu Lys Ala Glu Ala Asn Gly Asp Leu Lys Thr Val Ser Thr Lys 
                405                 410                 415     


Gly Lys Thr Thr Thr Ala Asp Ile His Ser Tyr Gly Ser Ser Gly Gly 
            420                 425                 430         


Gly Gly Ser Gly Gly Gly Gly Gly Val Gly Gly Ala Gly Gly Gly Pro 
        435                 440                 445             


Trp Gly Pro Ala Pro Ala Trp Cys Pro Cys Gly Ser Cys Cys Ser Trp 
    450                 455                 460                 


Trp Lys Trp Leu Leu Gly Leu Leu Leu Thr Trp Leu Leu Leu Leu Gly 
465                 470                 475                 480 


Leu Leu Phe Gly Leu Ile Ala Leu Ala Glu Glu Val Arg Lys Leu Lys 
                485                 490                 495     


Ala Arg Val Asp Glu Leu Glu Arg Ile Arg Arg Ser Ile Leu Pro Tyr 
            500                 505                 510         


Gly Asp Ser Met Asp Arg Ile Glu Lys Asp Arg Leu Gln Gly Met Ala 
        515                 520                 525             


Pro Ala Ala Gly Ala Asp Leu Asp Lys Ile Gly Leu His Ser Asp Ser 
    530                 535                 540                 


Gln Glu Glu Leu Trp Met Phe Val Arg Lys Lys Leu Met Met Glu Gln 
545                 550                 555                 560 


Glu Asn Gly Asn Leu Arg Gly Ser Pro Gly Pro Lys Gly Asp Met Gly 
                565                 570                 575     


Ser Pro Gly Pro Lys Gly Asp Arg Gly Phe Pro Gly Thr Pro Gly Ile 
            580                 585                 590         


Pro Gly Pro Leu Gly His Pro Gly Pro Gln Gly Pro Lys Gly Gln Lys 
        595                 600                 605             


Gly Ser Val Gly Asp Pro Gly Met Glu Gly Pro Met Gly Gln Arg Gly 
    610                 615                 620                 


Arg Glu Gly Pro Met Gly Pro Arg Gly Glu Ala Gly Pro Pro Gly Ser 
625                 630                 635                 640 


Gly Glu Lys Gly Glu Arg Gly Ala Ala Gly Glu Pro Gly Pro His Gly 
                645                 650                 655     


Pro Pro Gly Val Pro Gly Ser Val Gly Pro Lys Gly Ser Ser Gly Ser 
            660                 665                 670         


Pro Gly Pro Gln Gly Pro Pro Gly Pro Val Gly Leu Gln Gly Leu Arg 
        675                 680                 685             


Gly Glu Val Gly Leu Pro Gly Val Lys Gly Asp Lys Gly Pro Met Gly 
    690                 695                 700                 


Pro Pro Gly Pro Lys Gly Asp Gln Gly Glu Lys Gly Pro Arg Gly Leu 
705                 710                 715                 720 


Thr Gly Glu Pro Gly Met Arg Gly Leu Pro Gly Ala Val Gly Glu Pro 
                725                 730                 735     


Gly Ala Lys Gly Ala Met Gly Pro Ala Gly Pro Asp Gly His Gln Gly 
            740                 745                 750         


Pro Arg Gly Glu Gln Gly Leu Thr Gly Met Pro Gly Ile Arg Gly Pro 
        755                 760                 765             


Pro Gly Pro Ser Gly Asp Pro Gly Lys Pro Gly Leu Thr Gly Pro Gln 
    770                 775                 780                 


Gly Pro Gln Gly Leu Pro Gly Thr Pro Gly Arg Pro Gly Ile Lys Gly 
785                 790                 795                 800 


Glu Pro Gly Ala Pro Gly Lys Ile Val Thr Ser Glu Gly Ser Ser Met 
                805                 810                 815     


Leu Thr Val Pro Gly Pro Pro Gly Pro Pro Gly Ala Met Gly Pro Pro 
            820                 825                 830         


Gly Pro Pro Gly Ala Pro Gly Pro Ala Gly Pro Ala Gly Leu Pro Gly 
        835                 840                 845             


His Gln Glu Val Leu Asn Leu Gln Gly Pro Pro Gly Pro Pro Gly Pro 
    850                 855                 860                 


Arg Gly Pro Pro Gly Pro Ser Ile Pro Gly Pro Pro Gly Pro Arg Gly 
865                 870                 875                 880 


Pro Pro Gly Glu Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Ser Phe 
                885                 890                 895     


Leu Ser Asn Ser Glu Thr Phe Leu Ser Gly Pro Pro Gly Pro Pro Gly 
            900                 905                 910         


Pro Pro Gly Pro Lys Gly Asp Gln Gly Pro Pro Gly Pro Arg Gly His 
        915                 920                 925             


Gln Gly Glu Gln Gly Leu Pro Gly Phe Ser Thr Ser Gly Ser Ser Ser 
    930                 935                 940                 


Phe Gly Leu Asn Leu Gln Gly Pro Pro Gly Pro Pro Gly Pro Gln Gly 
945                 950                 955                 960 


Pro Lys Gly Asp Lys Gly Asp Pro Gly Val Pro Gly Ala Leu Gly Ile 
                965                 970                 975     


Pro Ser Gly Pro Ser Glu Gly Gly Ser Ser Ser Thr Met Tyr Val Ser 
            980                 985                 990         


Gly Pro Pro Gly Pro Pro Gly Pro  Pro Gly Pro Pro Gly  Ser Ile Ser 
        995                 1000                 1005             


Ser Ser  Gly Gln Glu Ile Gln  Gln Tyr Ile Ser Glu  Tyr Met Gln 
    1010                 1015                 1020             


Ser Asp  Ser Ile Arg Ser Tyr  Leu Ser Gly Val Gln  Gly Pro Pro 
    1025                 1030                 1035             


Gly Pro  Pro Gly Pro Pro Gly  Pro Val Thr Thr Ile  Thr Gly Glu 
    1040                 1045                 1050             


Thr Phe  Asp Tyr Ser Glu Leu  Ala Ser His Val Val  Ser Tyr Leu 
    1055                 1060                 1065             


Arg Thr  Ser Gly Tyr Gly Val  Ser Leu Phe Ser Ser  Ser Ile Ser 
    1070                 1075                 1080             


Ser Glu  Asp Ile Leu Ala Val  Leu Gln Arg Asp Asp  Val Arg Gln 
    1085                 1090                 1095             


Tyr Leu  Arg Gln Tyr Leu Met  Gly Pro Arg Gly Pro  Pro Gly Pro 
    1100                 1105                 1110             


Pro Gly  Ala Ser Gly Asp Gly  Ser Leu Leu Ser Leu  Asp Tyr Ala 
    1115                 1120                 1125             


Glu Leu  Ser Ser Arg Ile Leu  Ser Tyr Met Ser Ser  Ser Gly Ile 
    1130                 1135                 1140             


Ser Ile  Gly Leu Pro Gly Pro  Pro Gly Pro Pro Gly  Leu Pro Gly 
    1145                 1150                 1155             


Thr Ser  Tyr Glu Glu Leu Leu  Ser Leu Leu Arg Gly  Ser Glu Phe 
    1160                 1165                 1170             


Arg Gly  Ile Val Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Ile 
    1175                 1180                 1185             


Pro Gly  Asn Val Trp Ser Ser  Ile Ser Val Glu Asp  Leu Ser Ser 
    1190                 1195                 1200             


Tyr Leu  His Thr Ala Gly Leu  Ser Phe Ile Pro Gly  Pro Pro Gly 
    1205                 1210                 1215             


Pro Pro  Gly Pro Pro Gly Pro  Arg Gly Pro Pro Gly  Val Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Thr Tyr Ala Ala  Glu Asn Ser Asp Ser  Phe Arg Ser 
    1235                 1240                 1245             


Glu Leu  Ile Ser Tyr Leu Thr  Ser Pro Asp Val Arg  Ser Phe Ile 
    1250                 1255                 1260             


Val Gly  Pro Pro Gly Pro Pro  Gly Pro Gln Gly Pro  Pro Gly Asp 
    1265                 1270                 1275             


Ser Arg  Leu Leu Ser Thr Asp  Ala Ser His Ser Arg  Gly Ser Ser 
    1280                 1285                 1290             


Ser Ser  Ser His Ser Ser Ser  Val Arg Arg Gly Ser  Ser Tyr Ser 
    1295                 1300                 1305             


Ser Ser  Met Ser Thr Gly Gly  Gly Gly Ala Gly Ser  Leu Gly Ala 
    1310                 1315                 1320             


Gly Gly  Ala Phe Gly Glu Ala  Ala Gly Asp Arg Gly  Pro Tyr Gly 
    1325                 1330                 1335             


Thr Asp  Ile Gly Pro Gly Gly  Gly Tyr Gly Ala Ala  Ala Glu Gly 
    1340                 1345                 1350             


Gly Met  Tyr Ala Gly Asn Gly  Gly Leu Leu Gly Ala  Asp Phe Ala 
    1355                 1360                 1365             


Gly Asp  Leu Asp Tyr Asn Glu  Leu Ala Val Arg Val  Ser Glu Ser 
    1370                 1375                 1380             


Met Gln  Arg Gln Gly Leu Leu  Gln Gly Met Ala Tyr  Thr Val Gln 
    1385                 1390                 1395             


Gly Pro  Pro Gly Gln Pro Gly  Pro Gln Gly Pro Pro  Gly Ile Ser 
    1400                 1405                 1410             


Lys Val  Phe Ser Ala Tyr Ser  Asn Val Thr Ala Asp  Leu Met Asp 
    1415                 1420                 1425             


Phe Phe  Gln Thr Tyr Gly Ala  Ile Gln Gly Pro Pro  Gly Gln Lys 
    1430                 1435                 1440             


Gly Glu  Met Gly Thr Pro Gly  Pro Lys Gly Asp Arg  Gly Pro Ala 
    1445                 1450                 1455             


Gly Pro  Pro Gly His Pro Gly  Pro Pro Gly Pro Arg  Gly His Lys 
    1460                 1465                 1470             


Gly Glu  Lys Gly Asp Lys Gly  Asp Gln Val Tyr Ala  Gly Arg Arg 
    1475                 1480                 1485             


Arg Arg  Arg Ser Ile Ala Val  Lys Pro 
    1490                 1495         


<210>  141
<211>  512
<212>  PRT
<213>  Homo sapiens

<400>  141

Met Leu Phe Pro Ile Ser Met Ser Ala Thr Glu Phe Leu Leu Ala Ser 
1               5                   10                  15      


Val Ile Phe Cys Leu Val Phe Trp Val Ile Arg Ala Ser Arg Pro Gln 
            20                  25                  30          


Val Pro Lys Gly Leu Lys Asn Pro Pro Gly Pro Trp Gly Trp Pro Leu 
        35                  40                  45              


Ile Gly His Met Leu Thr Leu Gly Lys Asn Pro His Leu Ala Leu Ser 
    50                  55                  60                  


Arg Met Ser Gln Gln Tyr Gly Asp Val Leu Gln Ile Arg Ile Gly Ser 
65                  70                  75                  80  


Thr Pro Val Val Val Leu Ser Gly Leu Asp Thr Ile Arg Gln Ala Leu 
                85                  90                  95      


Val Arg Gln Gly Asp Asp Phe Lys Gly Arg Pro Asp Leu Tyr Thr Phe 
            100                 105                 110         


Thr Leu Ile Ser Asn Gly Gln Ser Met Ser Phe Ser Pro Asp Ser Gly 
        115                 120                 125             


Pro Val Trp Ala Ala Arg Arg Arg Leu Ala Gln Asn Gly Leu Lys Ser 
    130                 135                 140                 


Phe Ser Ile Ala Ser Asp Pro Ala Ser Ser Thr Ser Cys Tyr Leu Glu 
145                 150                 155                 160 


Glu His Val Ser Lys Glu Ala Glu Val Leu Ile Ser Thr Leu Gln Glu 
                165                 170                 175     


Leu Met Ala Gly Pro Gly His Phe Asn Pro Tyr Arg Tyr Val Val Val 
            180                 185                 190         


Ser Val Thr Asn Val Ile Cys Ala Ile Cys Phe Gly Arg Arg Tyr Asp 
        195                 200                 205             


His Asn His Gln Glu Leu Leu Ser Leu Val Asn Leu Asn Asn Asn Phe 
    210                 215                 220                 


Gly Glu Val Val Gly Ser Gly Asn Pro Ala Asp Phe Ile Pro Ile Leu 
225                 230                 235                 240 


Arg Tyr Leu Pro Asn Pro Ser Leu Asn Ala Phe Lys Asp Leu Asn Glu 
                245                 250                 255     


Lys Phe Tyr Ser Phe Met Gln Lys Met Val Lys Glu His Tyr Lys Thr 
            260                 265                 270         


Phe Glu Lys Gly His Ile Arg Asp Ile Thr Asp Ser Leu Ile Glu His 
        275                 280                 285             


Cys Gln Glu Lys Gln Leu Asp Glu Asn Ala Asn Val Gln Leu Ser Asp 
    290                 295                 300                 


Glu Lys Ile Ile Asn Ile Val Leu Asp Leu Phe Gly Ala Gly Phe Asp 
305                 310                 315                 320 


Thr Val Thr Thr Ala Ile Ser Trp Ser Leu Met Tyr Leu Val Met Asn 
                325                 330                 335     


Pro Arg Val Gln Arg Lys Ile Gln Glu Glu Leu Asp Thr Val Ile Gly 
            340                 345                 350         


Arg Ser Arg Arg Pro Arg Leu Ser Asp Arg Ser His Leu Pro Tyr Met 
        355                 360                 365             


Glu Ala Phe Ile Leu Glu Thr Phe Arg His Ser Ser Phe Val Pro Phe 
    370                 375                 380                 


Thr Ile Pro His Ser Thr Thr Arg Asp Thr Ser Leu Lys Gly Phe Tyr 
385                 390                 395                 400 


Ile Pro Lys Gly Arg Cys Val Phe Val Asn Gln Trp Gln Ile Asn His 
                405                 410                 415     


Asp Gln Lys Leu Trp Val Asn Pro Ser Glu Phe Leu Pro Glu Arg Phe 
            420                 425                 430         


Leu Thr Pro Asp Gly Ala Ile Asp Lys Val Leu Ser Glu Lys Val Ile 
        435                 440                 445             


Ile Phe Gly Met Gly Lys Arg Lys Cys Ile Gly Glu Thr Ile Ala Arg 
    450                 455                 460                 


Trp Glu Val Phe Leu Phe Leu Ala Ile Leu Leu Gln Arg Val Glu Phe 
465                 470                 475                 480 


Ser Val Pro Leu Gly Val Lys Val Asp Met Thr Pro Ile Tyr Gly Leu 
                485                 490                 495     


Thr Met Lys His Ala Cys Cys Glu His Phe Gln Met Gln Leu Arg Ser 
            500                 505                 510         


<210>  142
<211>  724
<212>  PRT
<213>  Homo sapiens

<400>  142

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30          


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45              


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60                  


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80  


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95      


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 
            100                 105                 110         


Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Gly Ala Val 
        115                 120                 125             


Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys Val Pro Gly Val 
    130                 135                 140                 


Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu Pro Gly Ala Arg Phe 
145                 150                 155                 160 


Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr Gly Ala Gly Val Lys 
                165                 170                 175     


Pro Lys Ala Pro Gly Val Gly Gly Ala Phe Ala Gly Ile Pro Gly Val 
            180                 185                 190         


Gly Pro Phe Gly Gly Pro Gln Pro Gly Val Pro Leu Gly Tyr Pro Ile 
        195                 200                 205             


Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly Leu Pro Tyr Thr Thr Gly 
    210                 215                 220                 


Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly Val Ala Gly Ala Ala Gly 
225                 230                 235                 240 


Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val Gly Pro Gln Ala Ala Ala 
                245                 250                 255     


Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe Gly Ala Gly Ala Ala Gly 
            260                 265                 270         


Val Leu Pro Gly Val Gly Gly Ala Gly Val Pro Gly Val Pro Gly Ala 
        275                 280                 285             


Ile Pro Gly Ile Gly Gly Ile Ala Gly Val Gly Thr Pro Ala Ala Ala 
    290                 295                 300                 


Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Ala 
305                 310                 315                 320 


Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro Gly Val Val Gly Val 
                325                 330                 335     


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Ile Pro 
            340                 345                 350         


Val Val Pro Gly Ala Gly Ile Pro Gly Ala Ala Val Pro Gly Val Val 
        355                 360                 365             


Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Lys Tyr Gly 
    370                 375                 380                 


Ala Arg Pro Gly Val Gly Val Gly Gly Ile Pro Thr Tyr Gly Val Gly 
385                 390                 395                 400 


Ala Gly Gly Phe Pro Gly Phe Gly Val Gly Val Gly Gly Ile Pro Gly 
                405                 410                 415     


Val Ala Gly Val Pro Gly Val Gly Gly Val Pro Gly Val Gly Gly Val 
            420                 425                 430         


Pro Gly Val Gly Ile Ser Pro Glu Ala Gln Ala Ala Ala Ala Ala Lys 
        435                 440                 445             


Ala Ala Lys Tyr Gly Val Gly Thr Pro Ala Ala Ala Ala Ala Lys Ala 
    450                 455                 460                 


Ala Ala Lys Ala Ala Gln Phe Gly Leu Val Pro Gly Val Gly Val Ala 
465                 470                 475                 480 


Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly 
                485                 490                 495     


Leu Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly 
            500                 505                 510         


Val Gly Val Ala Pro Gly Ile Gly Pro Gly Gly Val Ala Ala Ala Ala 
        515                 520                 525             


Lys Ser Ala Ala Lys Val Ala Ala Lys Ala Gln Leu Arg Ala Ala Ala 
    530                 535                 540                 


Gly Leu Gly Ala Gly Ile Pro Gly Leu Gly Val Gly Val Gly Val Pro 
545                 550                 555                 560 


Gly Leu Gly Val Gly Ala Gly Val Pro Gly Leu Gly Val Gly Ala Gly 
                565                 570                 575     


Val Pro Gly Phe Gly Ala Val Pro Gly Ala Leu Ala Ala Ala Lys Ala 
            580                 585                 590         


Ala Lys Tyr Gly Ala Ala Val Pro Gly Val Leu Gly Gly Leu Gly Ala 
        595                 600                 605             


Leu Gly Gly Val Gly Ile Pro Gly Gly Val Val Gly Ala Gly Pro Ala 
    610                 615                 620                 


Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln Phe Gly 
625                 630                 635                 640 


Leu Val Gly Ala Ala Gly Leu Gly Gly Leu Gly Val Gly Gly Leu Gly 
                645                 650                 655     


Val Pro Gly Val Gly Gly Leu Gly Gly Ile Pro Pro Ala Ala Ala Ala 
            660                 665                 670         


Lys Ala Ala Lys Tyr Gly Ala Ala Gly Leu Gly Gly Val Leu Gly Gly 
        675                 680                 685             


Ala Gly Gln Phe Pro Leu Gly Gly Val Ala Ala Arg Pro Gly Phe Gly 
    690                 695                 700                 


Leu Ser Pro Ile Phe Pro Gly Gly Ala Cys Leu Gly Lys Ala Cys Gly 
705                 710                 715                 720 


Arg Lys Arg Lys 
                


<210>  143
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  143

Met Gly Arg Pro Leu His Leu Val Leu Leu Ser Ala Ser Leu Ala Gly 
1               5                   10                  15      


Leu Leu Leu Leu Gly Glu Ser Leu Phe Ile Arg Arg Glu Gln Ala Asn 
            20                  25                  30          


Asn Ile Leu Ala Arg Val Thr Arg Ala Asn Ser Phe Leu Glu Glu Met 
        35                  40                  45              


Lys Lys Gly His Leu Glu Arg Glu Cys Met Glu Glu Thr Cys Ser Tyr 
    50                  55                  60                  


Glu Glu Ala Arg Glu Val Phe Glu Asp Ser Asp Lys Thr Asn Glu Phe 
65                  70                  75                  80  


Trp Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln 
                85                  90                  95      


Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys 
            100                 105                 110         


Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu 
        115                 120                 125             


Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln 
    130                 135                 140                 


Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn 
145                 150                 155                 160 


Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr 
                165                 170                 175     


Leu Glu Arg Arg Lys Arg Ser Val Ala Gln Ala Thr Ser Ser Ser Gly 
            180                 185                 190         


Glu Ala Pro Asp Ser Ile Thr Trp Lys Pro Tyr Asp Ala Ala Asp Leu 
        195                 200                 205             


Asp Pro Thr Glu Asn Pro Phe Asp Leu Leu Asp Phe Asn Gln Thr Gln 
    210                 215                 220                 


Pro Glu Arg Gly Asp Asn Asn Leu Thr Arg Ile Val Gly Gly Gln Glu 
225                 230                 235                 240 


Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu 
                245                 250                 255     


Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu 
            260                 265                 270         


Thr Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val 
        275                 280                 285             


Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu 
    290                 295                 300                 


Val Glu Val Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp 
305                 310                 315                 320 


Phe Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met 
                325                 330                 335     


Asn Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr 
            340                 345                 350         


Leu Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His 
        355                 360                 365             


Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr 
    370                 375                 380                 


Val Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln 
385                 390                 395                 400 


Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln 
                405                 410                 415     


Gly Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe 
            420                 425                 430         


Val Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys 
        435                 440                 445             


Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg 
    450                 455                 460                 


Ser Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu 
465                 470                 475                 480 


Val Ile Thr Ser Ser Pro Leu Lys 
                485             


<210>  144
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  144

Met Ser Trp Ser Leu His Pro Arg Asn Leu Ile Leu Tyr Phe Tyr Ala 
1               5                   10                  15      


Leu Leu Phe Leu Ser Ser Thr Cys Val Ala Tyr Val Ala Thr Arg Asp 
            20                  25                  30          


Asn Cys Cys Ile Leu Asp Glu Arg Phe Gly Ser Tyr Cys Pro Thr Thr 
        35                  40                  45              


Cys Gly Ile Ala Asp Phe Leu Ser Thr Tyr Gln Thr Lys Val Asp Lys 
    50                  55                  60                  


Asp Leu Gln Ser Leu Glu Asp Ile Leu His Gln Val Glu Asn Lys Thr 
65                  70                  75                  80  


Ser Glu Val Lys Gln Leu Ile Lys Ala Ile Gln Leu Thr Tyr Asn Pro 
                85                  90                  95      


Asp Glu Ser Ser Lys Pro Asn Met Ile Asp Ala Ala Thr Leu Lys Ser 
            100                 105                 110         


Arg Lys Met Leu Glu Glu Ile Met Lys Tyr Glu Ala Ser Ile Leu Thr 
        115                 120                 125             


His Asp Ser Ser Ile Arg Tyr Leu Gln Glu Ile Tyr Asn Ser Asn Asn 
    130                 135                 140                 


Gln Lys Ile Val Asn Leu Lys Glu Lys Val Ala Gln Leu Glu Ala Gln 
145                 150                 155                 160 


Cys Gln Glu Pro Cys Lys Asp Thr Val Gln Ile His Asp Ile Thr Gly 
                165                 170                 175     


Lys Asp Cys Gln Asp Ile Ala Asn Lys Gly Ala Lys Gln Ser Gly Leu 
            180                 185                 190         


Tyr Phe Ile Lys Pro Leu Lys Ala Asn Gln Gln Phe Leu Val Tyr Cys 
        195                 200                 205             


Glu Ile Asp Gly Ser Gly Asn Gly Trp Thr Val Phe Gln Lys Arg Leu 
    210                 215                 220                 


Asp Gly Ser Val Asp Phe Lys Lys Asn Trp Ile Gln Tyr Lys Glu Gly 
225                 230                 235                 240 


Phe Gly His Leu Ser Pro Thr Gly Thr Thr Glu Phe Trp Leu Gly Asn 
                245                 250                 255     


Glu Lys Ile His Leu Ile Ser Thr Gln Ser Ala Ile Pro Tyr Ala Leu 
            260                 265                 270         


Arg Val Glu Leu Glu Asp Trp Asn Gly Arg Thr Ser Thr Ala Asp Tyr 
        275                 280                 285             


Ala Met Phe Lys Val Gly Pro Glu Ala Asp Lys Tyr Arg Leu Thr Tyr 
    290                 295                 300                 


Ala Tyr Phe Ala Gly Gly Asp Ala Gly Asp Ala Phe Asp Gly Phe Asp 
305                 310                 315                 320 


Phe Gly Asp Asp Pro Ser Asp Lys Phe Phe Thr Ser His Asn Gly Met 
                325                 330                 335     


Gln Phe Ser Thr Trp Asp Asn Asp Asn Asp Lys Phe Glu Gly Asn Cys 
            340                 345                 350         


Ala Glu Gln Asp Gly Ser Gly Trp Trp Met Asn Lys Cys His Ala Gly 
        355                 360                 365             


His Leu Asn Gly Val Tyr Tyr Gln Gly Gly Thr Tyr Ser Lys Ala Ser 
    370                 375                 380                 


Thr Pro Asn Gly Tyr Asp Asn Gly Ile Ile Trp Ala Thr Trp Lys Thr 
385                 390                 395                 400 


Arg Trp Tyr Ser Met Lys Lys Thr Thr Met Lys Ile Ile Pro Phe Asn 
                405                 410                 415     


Arg Leu Thr Ile Gly Glu Gly Gln Gln His His Leu Gly Gly Ala Lys 
            420                 425                 430         


Gln Ala Gly Asp Val 
        435         


<210>  145
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  145

Met Leu Val Val Gln Met Pro Phe Ser Phe Pro Met Ala His Phe Ile 
1               5                   10                  15      


Leu Phe Val Phe Thr Val Ser Thr Ile Phe His Val Gln Gln Arg Leu 
            20                  25                  30          


Ala Lys Ile Gln Ala Met Trp Glu Leu Pro Val Gln Ile Pro Val Leu 
        35                  40                  45              


Ala Ser Thr Ser Lys Ala Leu Gly Pro Ser Gln Leu Arg Gly Met Trp 
    50                  55                  60                  


Thr Ile Asn Ala Ile Gly Arg Leu Gly Asn Gln Met Gly Glu Tyr Ala 
65                  70                  75                  80  


Thr Leu Tyr Ala Leu Ala Lys Met Asn Gly Arg Pro Ala Phe Ile Pro 
                85                  90                  95      


Ala Gln Met His Ser Thr Leu Ala Pro Ile Phe Arg Ile Thr Leu Pro 
            100                 105                 110         


Val Leu His Ser Ala Thr Ala Ser Arg Ile Pro Trp Gln Asn Tyr His 
        115                 120                 125             


Leu Asn Asp Trp Met Glu Glu Glu Tyr Arg His Ile Pro Gly Glu Tyr 
    130                 135                 140                 


Val Arg Phe Thr Gly Tyr Pro Cys Ser Trp Thr Phe Tyr His His Leu 
145                 150                 155                 160 


Arg Gln Glu Ile Leu Gln Glu Phe Thr Leu His Asp His Val Arg Glu 
                165                 170                 175     


Glu Ala Gln Lys Phe Leu Arg Gly Leu Gln Val Asn Gly Ser Arg Pro 
            180                 185                 190         


Gly Thr Phe Val Gly Val His Val Arg Arg Gly Asp Tyr Val His Val 
        195                 200                 205             


Met Pro Lys Val Trp Lys Gly Val Val Ala Asp Arg Arg Tyr Leu Gln 
    210                 215                 220                 


Gln Ala Leu Asp Trp Phe Arg Ala Arg Tyr Ser Ser Leu Ile Phe Val 
225                 230                 235                 240 


Val Thr Ser Asn Gly Met Ala Trp Cys Arg Glu Asn Ile Asp Thr Ser 
                245                 250                 255     


His Gly Asp Val Val Phe Ala Gly Asp Gly Ile Glu Gly Ser Pro Ala 
            260                 265                 270         


Lys Asp Phe Ala Leu Leu Thr Gln Cys Asn His Thr Ile Met Thr Ile 
        275                 280                 285             


Gly Thr Phe Gly Ile Trp Ala Ala Tyr Leu Thr Gly Gly Asp Thr Ile 
    290                 295                 300                 


Tyr Leu Ala Asn Tyr Thr Leu Pro Asp Ser Pro Phe Leu Lys Ile Phe 
305                 310                 315                 320 


Lys Pro Glu Ala Ala Phe Leu Pro Glu Trp Thr Gly Ile Ala Ala Asp 
                325                 330                 335     


Leu Ser Pro Leu Leu Lys His 
            340             


<210>  146
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  146

Met Ala Ala Val Val Ala Ala Thr Arg Trp Trp Gln Leu Leu Leu Val 
1               5                   10                  15      


Leu Ser Ala Ala Gly Met Gly Ala Ser Gly Ala Pro Gln Pro Pro Asn 
            20                  25                  30          


Ile Leu Leu Leu Leu Met Asp Asp Met Gly Trp Gly Asp Leu Gly Val 
        35                  40                  45              


Tyr Gly Glu Pro Ser Arg Glu Thr Pro Asn Leu Asp Arg Met Ala Ala 
    50                  55                  60                  


Glu Gly Leu Leu Phe Pro Asn Phe Tyr Ser Ala Asn Pro Leu Cys Ser 
65                  70                  75                  80  


Pro Ser Arg Ala Ala Leu Leu Thr Gly Arg Leu Pro Ile Arg Asn Gly 
                85                  90                  95      


Phe Tyr Thr Thr Asn Ala His Ala Arg Asn Ala Tyr Thr Pro Gln Glu 
            100                 105                 110         


Ile Val Gly Gly Ile Pro Asp Ser Glu Gln Leu Leu Pro Glu Leu Leu 
        115                 120                 125             


Lys Lys Ala Gly Tyr Val Ser Lys Ile Val Gly Lys Trp His Leu Gly 
    130                 135                 140                 


His Arg Pro Gln Phe His Pro Leu Lys His Gly Phe Asp Glu Trp Phe 
145                 150                 155                 160 


Gly Ser Pro Asn Cys His Phe Gly Pro Tyr Asp Asn Lys Ala Arg Pro 
                165                 170                 175     


Asn Ile Pro Val Tyr Arg Asp Trp Glu Met Val Gly Arg Tyr Tyr Glu 
            180                 185                 190         


Glu Phe Pro Ile Asn Leu Lys Thr Gly Glu Ala Asn Leu Thr Gln Ile 
        195                 200                 205             


Tyr Leu Gln Glu Ala Leu Asp Phe Ile Lys Arg Gln Ala Arg His His 
    210                 215                 220                 


Pro Phe Phe Leu Tyr Trp Ala Val Asp Ala Thr His Ala Pro Val Tyr 
225                 230                 235                 240 


Ala Ser Lys Pro Phe Leu Gly Thr Ser Gln Arg Gly Arg Tyr Gly Asp 
                245                 250                 255     


Ala Val Arg Glu Ile Asp Asp Ser Ile Gly Lys Ile Leu Glu Leu Leu 
            260                 265                 270         


Gln Asp Leu His Val Ala Asp Asn Thr Phe Val Phe Phe Thr Ser Asp 
        275                 280                 285             


Asn Gly Ala Ala Leu Ile Ser Ala Pro Glu Gln Gly Gly Ser Asn Gly 
    290                 295                 300                 


Pro Phe Leu Cys Gly Lys Gln Thr Thr Phe Glu Gly Gly Met Arg Glu 
305                 310                 315                 320 


Pro Ala Leu Ala Trp Trp Pro Gly His Val Thr Ala Gly Gln Val Ser 
                325                 330                 335     


His Gln Leu Gly Ser Ile Met Asp Leu Phe Thr Thr Ser Leu Ala Leu 
            340                 345                 350         


Ala Gly Leu Thr Pro Pro Ser Asp Arg Ala Ile Asp Gly Leu Asn Leu 
        355                 360                 365             


Leu Pro Thr Leu Leu Gln Gly Arg Leu Met Asp Arg Pro Ile Phe Tyr 
    370                 375                 380                 


Tyr Arg Gly Asp Thr Leu Met Ala Ala Thr Leu Gly Gln His Lys Ala 
385                 390                 395                 400 


His Phe Trp Thr Trp Thr Asn Ser Trp Glu Asn Phe Arg Gln Gly Ile 
                405                 410                 415     


Asp Phe Cys Pro Gly Gln Asn Val Ser Gly Val Thr Thr His Asn Leu 
            420                 425                 430         


Glu Asp His Thr Lys Leu Pro Leu Ile Phe His Leu Gly Arg Asp Pro 
        435                 440                 445             


Gly Glu Arg Phe Pro Leu Ser Phe Ala Ser Ala Glu Tyr Gln Glu Ala 
    450                 455                 460                 


Leu Ser Arg Ile Thr Ser Val Val Gln Gln His Gln Glu Ala Leu Val 
465                 470                 475                 480 


Pro Ala Gln Pro Gln Leu Asn Val Cys Asn Trp Ala Val Met Asn Trp 
                485                 490                 495     


Ala Pro Pro Gly Cys Glu Lys Leu Gly Lys Cys Leu Thr Pro Pro Glu 
            500                 505                 510         


Ser Ile Pro Lys Lys Cys Leu Trp Ser His 
        515                 520         


<210>  147
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  147

Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr 
1               5                   10                  15      


Ala Ser Ala Phe Pro Leu Pro Ala Gly Lys Arg Pro Pro Glu Ala Pro 
            20                  25                  30          


Ala Glu Asp Arg Ser Leu Gly Arg Arg Arg Ala Pro Phe Ala Leu Ser 
        35                  40                  45              


Ser Asp Ser Asn Met Pro Glu Asp Tyr Pro Asp Gln Phe Asp Asp Val 
    50                  55                  60                  


Met Asp Phe Ile Gln Ala Thr Ile Lys Arg Leu Lys Arg Ser Pro Asp 
65                  70                  75                  80  


Lys Gln Met Ala Val Leu Pro Arg Arg Glu Arg Asn Arg Gln Ala Ala 
                85                  90                  95      


Ala Ala Asn Pro Glu Asn Ser Arg Gly Lys Gly Arg Arg Gly Gln Arg 
            100                 105                 110         


Gly Lys Asn Arg Gly Cys Val Leu Thr Ala Ile His Leu Asn Val Thr 
        115                 120                 125             


Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu Ile Phe Arg Tyr 
    130                 135                 140                 


Cys Ser Gly Ser Cys Asp Ala Ala Glu Thr Thr Tyr Asp Lys Ile Leu 
145                 150                 155                 160 


Lys Asn Leu Ser Arg Asn Arg Arg Leu Val Ser Asp Lys Val Gly Gln 
                165                 170                 175     


Ala Cys Cys Arg Pro Ile Ala Phe Asp Asp Asp Leu Ser Phe Leu Asp 
            180                 185                 190         


Asp Asn Leu Val Tyr His Ile Leu Arg Lys His Ser Ala Lys Arg Cys 
        195                 200                 205             


Gly Cys Ile 
    210     


<210>  148
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  148

Met Val His Leu Thr Pro Glu Glu Lys Thr Ala Val Asn Ala Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Asp Ala Val Gly Gly Glu Ala Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp 
        35                  40                  45              


Leu Ser Ser Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp 
65                  70                  75                  80  


Asn Leu Lys Gly Thr Phe Ser Gln Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val 
            100                 105                 110         


Cys Val Leu Ala Arg Asn Phe Gly Lys Glu Phe Thr Pro Gln Met Gln 
        115                 120                 125             


Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His 
    130                 135                 140                 


Lys Tyr His 
145         


<210>  149
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  149

Met Glu Leu Cys Gly Leu Gly Leu Pro Arg Pro Pro Met Leu Leu Ala 
1               5                   10                  15      


Leu Leu Leu Ala Thr Leu Leu Ala Ala Met Leu Ala Leu Leu Thr Gln 
            20                  25                  30          


Val Ala Leu Val Val Gln Val Ala Glu Ala Ala Arg Ala Pro Ser Val 
        35                  40                  45              


Ser Ala Lys Pro Gly Pro Ala Leu Trp Pro Leu Pro Leu Ser Val Lys 
    50                  55                  60                  


Met Thr Pro Asn Leu Leu His Leu Ala Pro Glu Asn Phe Tyr Ile Ser 
65                  70                  75                  80  


His Ser Pro Asn Ser Thr Ala Gly Pro Ser Cys Thr Leu Leu Glu Glu 
                85                  90                  95      


Ala Phe Arg Arg Tyr His Gly Tyr Ile Phe Gly Phe Tyr Lys Trp His 
            100                 105                 110         


His Glu Pro Ala Glu Phe Gln Ala Lys Thr Gln Val Gln Gln Leu Leu 
        115                 120                 125             


Val Ser Ile Thr Leu Gln Ser Glu Cys Asp Ala Phe Pro Asn Ile Ser 
    130                 135                 140                 


Ser Asp Glu Ser Tyr Thr Leu Leu Val Lys Glu Pro Val Ala Val Leu 
145                 150                 155                 160 


Lys Ala Asn Arg Val Trp Gly Ala Leu Arg Gly Leu Glu Thr Phe Ser 
                165                 170                 175     


Gln Leu Val Tyr Gln Asp Ser Tyr Gly Thr Phe Thr Ile Asn Glu Ser 
            180                 185                 190         


Thr Ile Ile Asp Ser Pro Arg Phe Ser His Arg Gly Ile Leu Ile Asp 
        195                 200                 205             


Thr Ser Arg His Tyr Leu Pro Val Lys Ile Ile Leu Lys Thr Leu Asp 
    210                 215                 220                 


Ala Met Ala Phe Asn Lys Phe Asn Val Leu His Trp His Ile Val Asp 
225                 230                 235                 240 


Asp Gln Ser Phe Pro Tyr Gln Ser Ile Thr Phe Pro Glu Leu Ser Asn 
                245                 250                 255     


Lys Gly Ser Tyr Ser Leu Ser His Val Tyr Thr Pro Asn Asp Val Arg 
            260                 265                 270         


Met Val Ile Glu Tyr Ala Arg Leu Arg Gly Ile Arg Val Leu Pro Glu 
        275                 280                 285             


Phe Asp Thr Pro Gly His Thr Leu Ser Trp Gly Lys Gly Gln Lys Asp 
    290                 295                 300                 


Leu Leu Thr Pro Cys Tyr Ser Arg Gln Asn Lys Leu Asp Ser Phe Gly 
305                 310                 315                 320 


Pro Ile Asn Pro Thr Leu Asn Thr Thr Tyr Ser Phe Leu Thr Thr Phe 
                325                 330                 335     


Phe Lys Glu Ile Ser Glu Val Phe Pro Asp Gln Phe Ile His Leu Gly 
            340                 345                 350         


Gly Asp Glu Val Glu Phe Lys Cys Trp Glu Ser Asn Pro Lys Ile Gln 
        355                 360                 365             


Asp Phe Met Arg Gln Lys Gly Phe Gly Thr Asp Phe Lys Lys Leu Glu 
    370                 375                 380                 


Ser Phe Tyr Ile Gln Lys Val Leu Asp Ile Ile Ala Thr Ile Asn Lys 
385                 390                 395                 400 


Gly Ser Ile Val Trp Gln Glu Val Phe Asp Asp Lys Ala Lys Leu Ala 
                405                 410                 415     


Pro Gly Thr Ile Val Glu Val Trp Lys Asp Ser Ala Tyr Pro Glu Glu 
            420                 425                 430         


Leu Ser Arg Val Thr Ala Ser Gly Phe Pro Val Ile Leu Ser Ala Pro 
        435                 440                 445             


Trp Tyr Leu Asp Leu Ile Ser Tyr Gly Gln Asp Trp Arg Lys Tyr Tyr 
    450                 455                 460                 


Lys Val Glu Pro Leu Asp Phe Gly Gly Thr Gln Lys Gln Lys Gln Leu 
465                 470                 475                 480 


Phe Ile Gly Gly Glu Ala Cys Leu Trp Gly Glu Tyr Val Asp Ala Thr 
                485                 490                 495     


Asn Leu Thr Pro Arg Leu Trp Pro Arg Ala Ser Ala Val Gly Glu Arg 
            500                 505                 510         


Leu Trp Ser Ser Lys Asp Val Arg Asp Met Asp Asp Ala Tyr Asp Arg 
        515                 520                 525             


Leu Thr Arg His Arg Cys Arg Met Val Glu Arg Gly Ile Ala Ala Gln 
    530                 535                 540                 


Pro Leu Tyr Ala Gly Tyr Cys Asn His Glu Asn Met 
545                 550                 555     


<210>  150
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  150

Met Asp Val Leu Ser Pro Gly Gln Gly Asn Asn Thr Thr Ser Pro Pro 
1               5                   10                  15      


Ala Pro Phe Glu Thr Gly Gly Asn Thr Thr Gly Ile Ser Asp Val Thr 
            20                  25                  30          


Val Ser Tyr Gln Val Ile Thr Ser Leu Leu Leu Gly Thr Leu Ile Phe 
        35                  40                  45              


Cys Ala Val Leu Gly Asn Ala Cys Val Val Ala Ala Ile Ala Leu Glu 
    50                  55                  60                  


Arg Ser Leu Gln Asn Val Ala Asn Tyr Leu Ile Gly Ser Leu Ala Val 
65                  70                  75                  80  


Thr Asp Leu Met Val Ser Val Leu Val Leu Pro Met Ala Ala Leu Tyr 
                85                  90                  95      


Gln Val Leu Asn Lys Trp Thr Leu Gly Gln Val Thr Cys Asp Leu Phe 
            100                 105                 110         


Ile Ala Leu Asp Val Leu Cys Cys Thr Ser Ser Ile Leu His Leu Cys 
        115                 120                 125             


Ala Ile Ala Leu Asp Arg Tyr Trp Ala Ile Thr Asp Pro Ile Asp Tyr 
    130                 135                 140                 


Val Asn Lys Arg Thr Pro Arg Arg Ala Ala Ala Leu Ile Ser Leu Thr 
145                 150                 155                 160 


Trp Leu Ile Gly Phe Leu Ile Ser Ile Pro Pro Met Leu Gly Trp Arg 
                165                 170                 175     


Thr Pro Glu Asp Arg Ser Asp Pro Asp Ala Cys Thr Ile Ser Lys Asp 
            180                 185                 190         


His Gly Tyr Thr Ile Tyr Ser Thr Phe Gly Ala Phe Tyr Ile Pro Leu 
        195                 200                 205             


Leu Leu Met Leu Val Leu Tyr Gly Arg Ile Phe Arg Ala Ala Arg Phe 
    210                 215                 220                 


Arg Ile Arg Lys Thr Val Lys Lys Val Glu Lys Thr Gly Ala Asp Thr 
225                 230                 235                 240 


Arg His Gly Ala Ser Pro Ala Pro Gln Pro Lys Lys Ser Val Asn Gly 
                245                 250                 255     


Glu Ser Gly Ser Arg Asn Trp Arg Leu Gly Val Glu Ser Lys Ala Gly 
            260                 265                 270         


Gly Ala Leu Cys Ala Asn Gly Ala Val Arg Gln Gly Asp Asp Gly Ala 
        275                 280                 285             


Ala Leu Glu Val Ile Glu Val His Arg Val Gly Asn Ser Lys Glu His 
    290                 295                 300                 


Leu Pro Leu Pro Ser Glu Ala Gly Pro Thr Pro Cys Ala Pro Ala Ser 
305                 310                 315                 320 


Phe Glu Arg Lys Asn Glu Arg Asn Ala Glu Ala Lys Arg Lys Met Ala 
                325                 330                 335     


Leu Ala Arg Glu Arg Lys Thr Val Lys Thr Leu Gly Ile Ile Met Gly 
            340                 345                 350         


Thr Phe Ile Leu Cys Trp Leu Pro Phe Phe Ile Val Ala Leu Val Leu 
        355                 360                 365             


Pro Phe Cys Glu Ser Ser Cys His Met Pro Thr Leu Leu Gly Ala Ile 
    370                 375                 380                 


Ile Asn Trp Leu Gly Tyr Ser Asn Ser Leu Leu Asn Pro Val Ile Tyr 
385                 390                 395                 400 


Ala Tyr Phe Asn Lys Asp Phe Gln Asn Ala Phe Lys Lys Ile Ile Lys 
                405                 410                 415     


Cys Lys Phe Cys Arg Gln 
            420         


<210>  151
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  151

Met Leu Ser Arg Lys Gly Ile Ile Pro Glu Glu Tyr Val Leu Thr Arg 
1               5                   10                  15      


Leu Ala Glu Asp Pro Ala Lys Pro Arg Tyr Arg Ala Arg Gln Arg Arg 
            20                  25                  30          


Ala Arg Phe Val Ser Lys Lys Gly Asn Cys Asn Val Ala His Lys Asn 
        35                  40                  45              


Ile Arg Glu Gln Gly Arg Phe Leu Gln Asp Val Phe Thr Thr Leu Val 
    50                  55                  60                  


Asp Leu Lys Trp Pro His Thr Leu Leu Ile Phe Thr Met Ser Phe Leu 
65                  70                  75                  80  


Cys Ser Trp Leu Leu Phe Ala Met Ala Trp Trp Leu Ile Ala Phe Ala 
                85                  90                  95      


His Gly Asp Leu Ala Pro Ser Glu Gly Thr Ala Glu Pro Cys Val Thr 
            100                 105                 110         


Ser Ile His Ser Phe Ser Ser Ala Phe Leu Phe Ser Ile Glu Val Gln 
        115                 120                 125             


Val Thr Ile Gly Phe Gly Gly Arg Met Val Thr Glu Glu Cys Pro Leu 
    130                 135                 140                 


Ala Ile Leu Ile Leu Ile Val Gln Asn Ile Val Gly Leu Met Ile Asn 
145                 150                 155                 160 


Ala Ile Met Leu Gly Cys Ile Phe Met Lys Thr Ala Gln Ala His Arg 
                165                 170                 175     


Arg Ala Glu Thr Leu Ile Phe Ser Lys His Ala Val Ile Ala Leu Arg 
            180                 185                 190         


His Gly Arg Leu Cys Phe Met Leu Arg Val Gly Asp Leu Arg Lys Ser 
        195                 200                 205             


Met Ile Ile Ser Ala Thr Ile His Met Gln Val Val Arg Lys Thr Thr 
    210                 215                 220                 


Ser Pro Glu Gly Glu Val Val Pro Leu His Gln Val Asp Ile Pro Met 
225                 230                 235                 240 


Glu Asn Gly Val Gly Gly Asn Ser Ile Phe Leu Val Ala Pro Leu Ile 
                245                 250                 255     


Ile Tyr His Val Ile Asp Ala Asn Ser Pro Leu Tyr Asp Leu Ala Pro 
            260                 265                 270         


Ser Asp Leu His His His Gln Asp Leu Glu Ile Ile Val Ile Leu Glu 
        275                 280                 285             


Gly Val Val Glu Thr Thr Gly Ile Thr Thr Gln Ala Arg Thr Ser Tyr 
    290                 295                 300                 


Leu Ala Asp Glu Ile Leu Trp Gly Gln Arg Phe Val Pro Ile Val Ala 
305                 310                 315                 320 


Glu Glu Asp Gly Arg Tyr Ser Val Asp Tyr Ser Lys Phe Gly Asn Thr 
                325                 330                 335     


Val Lys Val Pro Thr Pro Leu Cys Thr Ala Arg Gln Leu Asp Glu Asp 
            340                 345                 350         


His Ser Leu Leu Glu Ala Leu Thr Leu Ala Ser Ala Arg Gly Pro Leu 
        355                 360                 365             


Arg Lys Arg Ser Val Pro Met Ala Lys Ala Lys Pro Lys Phe Ser Ile 
    370                 375                 380                 


Ser Pro Asp Ser Leu Ser 
385                 390 


<210>  152
<211>  860
<212>  PRT
<213>  Homo sapiens

<400>  152

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp 
            100                 105                 110         


Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys 
        115                 120                 125             


Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro 
    130                 135                 140                 


Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys 
145                 150                 155                 160 


Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly 
                165                 170                 175     


Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly 
            180                 185                 190         


Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu 
        195                 200                 205             


Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp 
    210                 215                 220                 


Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu 
225                 230                 235                 240 


Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp 
                245                 250                 255     


Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn 
            260                 265                 270         


Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu 
        275                 280                 285             


Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp 
    290                 295                 300                 


Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp 
305                 310                 315                 320 


Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr 
                325                 330                 335     


Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys 
            340                 345                 350         


Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys 
        355                 360                 365             


Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln 
    370                 375                 380                 


Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr 
385                 390                 395                 400 


Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg 
                405                 410                 415     


Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu 
            420                 425                 430         


Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln 
        435                 440                 445             


Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser 
    450                 455                 460                 


Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala 
465                 470                 475                 480 


Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly 
                485                 490                 495     


Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe 
            500                 505                 510         


Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His 
        515                 520                 525             


Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys 
    530                 535                 540                 


Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile 
545                 550                 555                 560 


Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr 
                565                 570                 575     


Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly 
            580                 585                 590         


Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro 
        595                 600                 605             


Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile 
    610                 615                 620                 


Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn 
625                 630                 635                 640 


Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His 
                645                 650                 655     


Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu 
            660                 665                 670         


Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn 
        675                 680                 685             


Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu 
    690                 695                 700                 


Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala 
705                 710                 715                 720 


Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val 
                725                 730                 735     


Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu 
            740                 745                 750         


Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser 
        755                 760                 765             


His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro 
    770                 775                 780                 


Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val 
785                 790                 795                 800 


Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys 
                805                 810                 815     


Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr 
            820                 825                 830         


Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro 
        835                 840                 845             


Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala 
    850                 855                 860 


<210>  153
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  153

Met Lys His Ile Ile Asn Ser Tyr Glu Asn Ile Asn Asn Thr Ala Arg 
1               5                   10                  15      


Asn Asn Ser Asp Cys Pro Arg Val Val Leu Pro Glu Glu Ile Phe Phe 
            20                  25                  30          


Thr Ile Ser Ile Val Gly Val Leu Glu Asn Leu Ile Val Leu Leu Ala 
        35                  40                  45              


Val Phe Lys Asn Lys Asn Leu Gln Ala Pro Met Tyr Phe Phe Ile Cys 
    50                  55                  60                  


Ser Leu Ala Ile Ser Asp Met Leu Gly Ser Leu Tyr Lys Ile Leu Glu 
65                  70                  75                  80  


Asn Ile Leu Ile Ile Leu Arg Asn Met Gly Tyr Leu Lys Pro Arg Gly 
                85                  90                  95      


Ser Phe Glu Thr Thr Ala Asp Asp Ile Ile Asp Ser Leu Phe Val Leu 
            100                 105                 110         


Ser Leu Leu Gly Ser Ile Phe Ser Leu Ser Val Ile Ala Ala Asp Arg 
        115                 120                 125             


Tyr Ile Thr Ile Phe His Ala Leu Arg Tyr His Ser Ile Val Thr Met 
    130                 135                 140                 


Arg Arg Thr Val Val Val Leu Thr Val Ile Trp Thr Phe Cys Thr Gly 
145                 150                 155                 160 


Thr Gly Ile Thr Met Val Ile Phe Ser His His Val Pro Thr Val Ile 
                165                 170                 175     


Thr Phe Thr Ser Leu Phe Pro Leu Met Leu Val Phe Ile Leu Cys Leu 
            180                 185                 190         


Tyr Val His Met Phe Leu Leu Ala Arg Ser His Thr Arg Lys Ile Ser 
        195                 200                 205             


Thr Leu Pro Arg Ala Asn Met Lys Gly Ala Ile Thr Leu Thr Ile Leu 
    210                 215                 220                 


Leu Gly Val Phe Ile Phe Cys Trp Ala Pro Phe Val Leu His Val Leu 
225                 230                 235                 240 


Leu Met Thr Phe Cys Pro Ser Asn Pro Tyr Cys Ala Cys Tyr Met Ser 
                245                 250                 255     


Leu Phe Gln Val Asn Gly Met Leu Ile Met Cys Asn Ala Val Ile Asp 
            260                 265                 270         


Pro Phe Ile Tyr Ala Phe Arg Ser Pro Glu Leu Arg Asp Ala Phe Lys 
        275                 280                 285             


Lys Met Ile Phe Cys Ser Arg Tyr Trp 
    290                 295         


<210>  154
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  154

Met Ala Pro Gly Ala Pro Ser Ser Ser Pro Ser Pro Ile Leu Ala Val 
1               5                   10                  15      


Leu Leu Phe Ser Ser Leu Val Leu Ser Pro Ala Gln Ala Ile Val Val 
            20                  25                  30          


Tyr Thr Asp Arg Glu Val His Gly Ala Val Gly Ser Arg Val Thr Leu 
        35                  40                  45              


His Cys Ser Phe Trp Ser Ser Glu Trp Val Ser Asp Asp Ile Ser Phe 
    50                  55                  60                  


Thr Trp Arg Tyr Gln Pro Glu Gly Gly Arg Asp Ala Ile Ser Ile Phe 
65                  70                  75                  80  


His Tyr Ala Lys Gly Gln Pro Tyr Ile Asp Glu Val Gly Thr Phe Lys 
                85                  90                  95      


Glu Arg Ile Gln Trp Val Gly Asp Pro Arg Trp Lys Asp Gly Ser Ile 
            100                 105                 110         


Val Ile His Asn Leu Asp Tyr Ser Asp Asn Gly Thr Phe Thr Cys Asp 
        115                 120                 125             


Val Lys Asn Pro Pro Asp Ile Val Gly Lys Thr Ser Gln Val Thr Leu 
    130                 135                 140                 


Tyr Val Phe Glu Lys Val Pro Thr Arg Tyr Gly Val Val Leu Gly Ala 
145                 150                 155                 160 


Val Ile Gly Gly Val Leu Gly Val Val Leu Leu Leu Leu Leu Leu Phe 
                165                 170                 175     


Tyr Val Val Arg Tyr Cys Trp Leu Arg Arg Gln Ala Ala Leu Gln Arg 
            180                 185                 190         


Arg Leu Ser Ala Met Glu Lys Gly Lys Leu His Lys Pro Gly Lys Asp 
        195                 200                 205             


Ala Ser Lys Arg Gly Arg Gln Thr Pro Val Leu Tyr Ala Met Leu Asp 
    210                 215                 220                 


His Ser Arg Ser Thr Lys Ala Val Ser Glu Lys Lys Ala Lys Gly Leu 
225                 230                 235                 240 


Gly Glu Ser Arg Lys Asp Lys Lys 
                245             


<210>  155
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  155

Met Gly Leu Leu Glu Cys Cys Ala Arg Cys Leu Val Gly Ala Pro Phe 
1               5                   10                  15      


Ala Ser Leu Val Ala Thr Gly Leu Cys Phe Phe Gly Val Ala Leu Phe 
            20                  25                  30          


Cys Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu 
        35                  40                  45              


Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val 
    50                  55                  60                  


Ile His Ala Phe Gln Tyr Val Ile Tyr Gly Thr Ala Ser Phe Phe Phe 
65                  70                  75                  80  


Leu Tyr Gly Ala Leu Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly Ala 
                85                  90                  95      


Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys Gly 
            100                 105                 110         


Leu Ser Ala Thr Val Thr Gly Gly Gln Lys Gly Arg Gly Ser Arg Gly 
        115                 120                 125             


Gln His Gln Ala His Ser Leu Glu Arg Val Cys His Cys Leu Gly Lys 
    130                 135                 140                 


Trp Leu Gly His Pro Asp Lys Phe Val Gly Ile Thr Tyr Ala Leu Thr 
145                 150                 155                 160 


Val Val Trp Leu Leu Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile 
                165                 170                 175     


Tyr Phe Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys 
            180                 185                 190         


Thr Ser Ala Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly 
        195                 200                 205             


Val Leu Pro Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn Leu 
    210                 215                 220                 


Leu Ser Ile Cys Lys Thr Ala Glu Phe Gln Met Thr Phe His Leu Phe 
225                 230                 235                 240 


Ile Ala Ala Phe Val Gly Ala Ala Ala Thr Leu Val Ser Leu Leu Thr 
                245                 250                 255     


Phe Met Ile Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly 
            260                 265                 270         


Arg Gly Thr Lys Phe 
        275         


<210>  156
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  156

Met Asn Gly Thr Glu Gly Pro Asn Phe Tyr Val Pro Phe Ser Asn Ala 
1               5                   10                  15      


Thr Gly Val Val Arg Ser Pro Phe Glu Tyr Pro Gln Tyr Tyr Leu Ala 
            20                  25                  30          


Glu Pro Trp Gln Phe Ser Met Leu Ala Ala Tyr Met Phe Leu Leu Ile 
        35                  40                  45              


Val Leu Gly Phe Pro Ile Asn Phe Leu Thr Leu Tyr Val Thr Val Gln 
    50                  55                  60                  


His Lys Lys Leu Arg Thr Pro Leu Asn Tyr Ile Leu Leu Asn Leu Ala 
65                  70                  75                  80  


Val Ala Asp Leu Phe Met Val Leu Gly Gly Phe Thr Ser Thr Leu Tyr 
                85                  90                  95      


Thr Ser Leu His Gly Tyr Phe Val Phe Gly Pro Thr Gly Cys Asn Leu 
            100                 105                 110         


Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile Ala Leu Trp Ser Leu 
        115                 120                 125             


Val Val Leu Ala Ile Glu Arg Tyr Val Val Val Cys Lys Pro Met Ser 
    130                 135                 140                 


Asn Phe Arg Phe Gly Glu Asn His Ala Ile Met Gly Val Ala Phe Thr 
145                 150                 155                 160 


Trp Val Met Ala Leu Ala Cys Ala Ala Pro Pro Leu Ala Gly Trp Ser 
                165                 170                 175     


Arg Tyr Ile Pro Glu Gly Leu Gln Cys Ser Cys Gly Ile Asp Tyr Tyr 
            180                 185                 190         


Thr Leu Lys Pro Glu Val Asn Asn Glu Ser Phe Val Ile Tyr Met Phe 
        195                 200                 205             


Val Val His Phe Thr Ile Pro Met Ile Ile Ile Phe Phe Cys Tyr Gly 
    210                 215                 220                 


Gln Leu Val Phe Thr Val Lys Glu Ala Ala Ala Gln Gln Gln Glu Ser 
225                 230                 235                 240 


Ala Thr Thr Gln Lys Ala Glu Lys Glu Val Thr Arg Met Val Ile Ile 
                245                 250                 255     


Met Val Ile Ala Phe Leu Ile Cys Trp Val Pro Tyr Ala Ser Val Ala 
            260                 265                 270         


Phe Tyr Ile Phe Thr His Gln Gly Ser Asn Phe Gly Pro Ile Phe Met 
        275                 280                 285             


Thr Ile Pro Ala Phe Phe Ala Lys Ser Ala Ala Ile Tyr Asn Pro Val 
    290                 295                 300                 


Ile Tyr Ile Met Met Asn Lys Gln Phe Arg Asn Cys Met Leu Thr Thr 
305                 310                 315                 320 


Ile Cys Cys Gly Lys Asn Pro Leu Gly Asp Asp Glu Ala Ser Ala Thr 
                325                 330                 335     


Val Ser Lys Thr Glu Thr Ser Gln Val Ala Pro Ala 
            340                 345             


<210>  157
<211>  5038
<212>  PRT
<213>  Homo sapiens

<400>  157

Met Gly Asp Ala Glu Gly Glu Asp Glu Val Gln Phe Leu Arg Thr Asp 
1               5                   10                  15      


Asp Glu Val Val Leu Gln Cys Ser Ala Thr Val Leu Lys Glu Gln Leu 
            20                  25                  30          


Lys Leu Cys Leu Ala Ala Glu Gly Phe Gly Asn Arg Leu Cys Phe Leu 
        35                  40                  45              


Glu Pro Thr Ser Asn Ala Gln Asn Val Pro Pro Asp Leu Ala Ile Cys 
    50                  55                  60                  


Cys Phe Val Leu Glu Gln Ser Leu Ser Val Arg Ala Leu Gln Glu Met 
65                  70                  75                  80  


Leu Ala Asn Thr Val Glu Ala Gly Val Glu Ser Ser Gln Gly Gly Gly 
                85                  90                  95      


His Arg Thr Leu Leu Tyr Gly His Ala Ile Leu Leu Arg His Ala His 
            100                 105                 110         


Ser Arg Met Tyr Leu Ser Cys Leu Thr Thr Ser Arg Ser Met Thr Asp 
        115                 120                 125             


Lys Leu Ala Phe Asp Val Gly Leu Gln Glu Asp Ala Thr Gly Glu Ala 
    130                 135                 140                 


Cys Trp Trp Thr Met His Pro Ala Ser Lys Gln Arg Ser Glu Gly Glu 
145                 150                 155                 160 


Lys Val Arg Val Gly Asp Asp Ile Ile Leu Val Ser Val Ser Ser Glu 
                165                 170                 175     


Arg Tyr Leu His Leu Ser Thr Ala Ser Gly Glu Leu Gln Val Asp Ala 
            180                 185                 190         


Ser Phe Met Gln Thr Leu Trp Asn Met Asn Pro Ile Cys Ser Arg Cys 
        195                 200                 205             


Glu Glu Gly Phe Val Thr Gly Gly His Val Leu Arg Leu Phe His Gly 
    210                 215                 220                 


His Met Asp Glu Cys Leu Thr Ile Ser Pro Ala Asp Ser Asp Asp Gln 
225                 230                 235                 240 


Arg Arg Leu Val Tyr Tyr Glu Gly Gly Ala Val Cys Thr His Ala Arg 
                245                 250                 255     


Ser Leu Trp Arg Leu Glu Pro Leu Arg Ile Ser Trp Ser Gly Ser His 
            260                 265                 270         


Leu Arg Trp Gly Gln Pro Leu Arg Val Arg His Val Thr Thr Gly Gln 
        275                 280                 285             


Tyr Leu Ala Leu Thr Glu Asp Gln Gly Leu Val Val Val Asp Ala Ser 
    290                 295                 300                 


Lys Ala His Thr Lys Ala Thr Ser Phe Cys Phe Arg Ile Ser Lys Glu 
305                 310                 315                 320 


Lys Leu Asp Val Ala Pro Lys Arg Asp Val Glu Gly Met Gly Pro Pro 
                325                 330                 335     


Glu Ile Lys Tyr Gly Glu Ser Leu Cys Phe Val Gln His Val Ala Ser 
            340                 345                 350         


Gly Leu Trp Leu Thr Tyr Ala Ala Pro Asp Pro Lys Ala Leu Arg Leu 
        355                 360                 365             


Gly Val Leu Lys Lys Lys Ala Met Leu His Gln Glu Gly His Met Asp 
    370                 375                 380                 


Asp Ala Leu Ser Leu Thr Arg Cys Gln Gln Glu Glu Ser Gln Ala Ala 
385                 390                 395                 400 


Arg Met Ile His Ser Thr Asn Gly Leu Tyr Asn Gln Phe Ile Lys Ser 
                405                 410                 415     


Leu Asp Ser Phe Ser Gly Lys Pro Arg Gly Ser Gly Pro Pro Ala Gly 
            420                 425                 430         


Thr Ala Leu Pro Ile Glu Gly Val Ile Leu Ser Leu Gln Asp Leu Ile 
        435                 440                 445             


Ile Tyr Phe Glu Pro Pro Ser Glu Asp Leu Gln His Glu Glu Lys Gln 
    450                 455                 460                 


Ser Lys Leu Arg Ser Leu Arg Asn Arg Gln Ser Leu Phe Gln Glu Glu 
465                 470                 475                 480 


Gly Met Leu Ser Met Val Leu Asn Cys Ile Asp Arg Leu Asn Val Tyr 
                485                 490                 495     


Thr Thr Ala Ala His Phe Ala Glu Phe Ala Gly Glu Glu Ala Ala Glu 
            500                 505                 510         


Ser Trp Lys Glu Ile Val Asn Leu Leu Tyr Glu Leu Leu Ala Ser Leu 
        515                 520                 525             


Ile Arg Gly Asn Arg Ser Asn Cys Ala Leu Phe Ser Thr Asn Leu Asp 
    530                 535                 540                 


Trp Leu Val Ser Lys Leu Asp Arg Leu Glu Ala Ser Ser Gly Ile Leu 
545                 550                 555                 560 


Glu Val Leu Tyr Cys Val Leu Ile Glu Ser Pro Glu Val Leu Asn Ile 
                565                 570                 575     


Ile Gln Glu Asn His Ile Lys Ser Ile Ile Ser Leu Leu Asp Lys His 
            580                 585                 590         


Gly Arg Asn His Lys Val Leu Asp Val Leu Cys Ser Leu Cys Val Cys 
        595                 600                 605             


Asn Gly Val Ala Val Arg Ser Asn Gln Asp Leu Ile Thr Glu Asn Leu 
    610                 615                 620                 


Leu Pro Gly Arg Glu Leu Leu Leu Gln Thr Asn Leu Ile Asn Tyr Val 
625                 630                 635                 640 


Thr Ser Ile Arg Pro Asn Ile Phe Val Gly Arg Ala Glu Gly Thr Thr 
                645                 650                 655     


Gln Tyr Ser Lys Trp Tyr Phe Glu Val Met Val Asp Glu Val Thr Pro 
            660                 665                 670         


Phe Leu Thr Ala Gln Ala Thr His Leu Arg Val Gly Trp Ala Leu Thr 
        675                 680                 685             


Glu Gly Tyr Thr Pro Tyr Pro Gly Ala Gly Glu Gly Trp Gly Gly Asn 
    690                 695                 700                 


Gly Val Gly Asp Asp Leu Tyr Ser Tyr Gly Phe Asp Gly Leu His Leu 
705                 710                 715                 720 


Trp Thr Gly His Val Ala Arg Pro Val Thr Ser Pro Gly Gln His Leu 
                725                 730                 735     


Leu Ala Pro Glu Asp Val Ile Ser Cys Cys Leu Asp Leu Ser Val Pro 
            740                 745                 750         


Ser Ile Ser Phe Arg Ile Asn Gly Cys Pro Val Gln Gly Val Phe Glu 
        755                 760                 765             


Ser Phe Asn Leu Asp Gly Leu Phe Phe Pro Val Val Ser Phe Ser Ala 
    770                 775                 780                 


Gly Val Lys Val Arg Phe Leu Leu Gly Gly Arg His Gly Glu Phe Lys 
785                 790                 795                 800 


Phe Leu Pro Pro Pro Gly Tyr Ala Pro Cys His Glu Ala Val Leu Pro 
                805                 810                 815     


Arg Glu Arg Leu His Leu Glu Pro Ile Lys Glu Tyr Arg Arg Glu Gly 
            820                 825                 830         


Pro Arg Gly Pro His Leu Val Gly Pro Ser Arg Cys Leu Ser His Thr 
        835                 840                 845             


Asp Phe Val Pro Cys Pro Val Asp Thr Val Gln Ile Val Leu Pro Pro 
    850                 855                 860                 


His Leu Glu Arg Ile Arg Glu Lys Leu Ala Glu Asn Ile His Glu Leu 
865                 870                 875                 880 


Trp Ala Leu Thr Arg Ile Glu Gln Gly Trp Thr Tyr Gly Pro Val Arg 
                885                 890                 895     


Asp Asp Asn Lys Arg Leu His Pro Cys Leu Val Asp Phe His Ser Leu 
            900                 905                 910         


Pro Glu Pro Glu Arg Asn Tyr Asn Leu Gln Met Ser Gly Glu Thr Leu 
        915                 920                 925             


Lys Thr Leu Leu Ala Leu Gly Cys His Val Gly Met Ala Asp Glu Lys 
    930                 935                 940                 


Ala Glu Asp Asn Leu Lys Lys Thr Lys Leu Pro Lys Thr Tyr Met Met 
945                 950                 955                 960 


Ser Asn Gly Tyr Lys Pro Ala Pro Leu Asp Leu Ser His Val Arg Leu 
                965                 970                 975     


Thr Pro Ala Gln Thr Thr Leu Val Asp Arg Leu Ala Glu Asn Gly His 
            980                 985                 990         


Asn Val Trp Ala Arg Asp Arg Val  Gly Gln Gly Trp Ser  Tyr Ser Ala 
        995                 1000                 1005             


Val Gln  Asp Ile Pro Ala Arg  Arg Asn Pro Arg Leu  Val Pro Tyr 
    1010                 1015                 1020             


Arg Leu  Leu Asp Glu Ala Thr  Lys Arg Ser Asn Arg  Asp Ser Leu 
    1025                 1030                 1035             


Cys Gln  Ala Val Arg Thr Leu  Leu Gly Tyr Gly Tyr  Asn Ile Glu 
    1040                 1045                 1050             


Pro Pro  Asp Gln Glu Pro Ser  Gln Val Glu Asn Gln  Ser Arg Cys 
    1055                 1060                 1065             


Asp Arg  Val Arg Ile Phe Arg  Ala Glu Lys Ser Tyr  Thr Val Gln 
    1070                 1075                 1080             


Ser Gly  Arg Trp Tyr Phe Glu  Phe Glu Ala Val Thr  Thr Gly Glu 
    1085                 1090                 1095             


Met Arg  Val Gly Trp Ala Arg  Pro Glu Leu Arg Pro  Asp Val Glu 
    1100                 1105                 1110             


Leu Gly  Ala Asp Glu Leu Ala  Tyr Val Phe Asn Gly  His Arg Gly 
    1115                 1120                 1125             


Gln Arg  Trp His Leu Gly Ser  Glu Pro Phe Gly Arg  Pro Trp Gln 
    1130                 1135                 1140             


Pro Gly  Asp Val Val Gly Cys  Met Ile Asp Leu Thr  Glu Asn Thr 
    1145                 1150                 1155             


Ile Ile  Phe Thr Leu Asn Gly  Glu Val Leu Met Ser  Asp Ser Gly 
    1160                 1165                 1170             


Ser Glu  Thr Ala Phe Arg Glu  Ile Glu Ile Gly Asp  Gly Phe Leu 
    1175                 1180                 1185             


Pro Val  Cys Ser Leu Gly Pro  Gly Gln Val Gly His  Leu Asn Leu 
    1190                 1195                 1200             


Gly Gln  Asp Val Ser Ser Leu  Arg Phe Phe Ala Ile  Cys Gly Leu 
    1205                 1210                 1215             


Gln Glu  Gly Phe Glu Pro Phe  Ala Ile Asn Met Gln  Arg Pro Val 
    1220                 1225                 1230             


Thr Thr  Trp Phe Ser Lys Gly  Leu Pro Gln Phe Glu  Pro Val Pro 
    1235                 1240                 1245             


Leu Glu  His Pro His Tyr Glu  Val Ser Arg Val Asp  Gly Thr Val 
    1250                 1255                 1260             


Asp Thr  Pro Pro Cys Leu Arg  Leu Thr His Arg Thr  Trp Gly Ser 
    1265                 1270                 1275             


Gln Asn  Ser Leu Val Glu Met  Leu Phe Leu Arg Leu  Ser Leu Pro 
    1280                 1285                 1290             


Val Gln  Phe His Gln His Phe  Arg Cys Thr Ala Gly  Ala Thr Pro 
    1295                 1300                 1305             


Leu Ala  Pro Pro Gly Leu Gln  Pro Pro Ala Glu Asp  Glu Ala Arg 
    1310                 1315                 1320             


Ala Ala  Glu Pro Asp Pro Asp  Tyr Glu Asn Leu Arg  Arg Ser Ala 
    1325                 1330                 1335             


Gly Gly  Trp Ser Glu Ala Glu  Asn Gly Lys Glu Gly  Thr Ala Lys 
    1340                 1345                 1350             


Glu Gly  Ala Pro Gly Gly Thr  Pro Gln Ala Gly Gly  Glu Ala Gln 
    1355                 1360                 1365             


Pro Ala  Arg Ala Glu Asn Glu  Lys Asp Ala Thr Thr  Glu Lys Asn 
    1370                 1375                 1380             


Lys Lys  Arg Gly Phe Leu Phe  Lys Ala Lys Lys Val  Ala Met Met 
    1385                 1390                 1395             


Thr Gln  Pro Pro Ala Thr Pro  Thr Leu Pro Arg Leu  Pro His Asp 
    1400                 1405                 1410             


Val Val  Pro Ala Asp Asn Arg  Asp Asp Pro Glu Ile  Ile Leu Asn 
    1415                 1420                 1425             


Thr Thr  Thr Tyr Tyr Tyr Ser  Val Arg Val Phe Ala  Gly Gln Glu 
    1430                 1435                 1440             


Pro Ser  Cys Val Trp Ala Gly  Trp Val Thr Pro Asp  Tyr His Gln 
    1445                 1450                 1455             


His Asp  Met Ser Phe Asp Leu  Ser Lys Val Arg Val  Val Thr Val 
    1460                 1465                 1470             


Thr Met  Gly Asp Glu Gln Gly  Asn Val His Ser Ser  Leu Lys Cys 
    1475                 1480                 1485             


Ser Asn  Cys Tyr Met Val Trp  Gly Gly Asp Phe Val  Ser Pro Gly 
    1490                 1495                 1500             


Gln Gln  Gly Arg Ile Ser His  Thr Asp Leu Val Ile  Gly Cys Leu 
    1505                 1510                 1515             


Val Asp  Leu Ala Thr Gly Leu  Met Thr Phe Thr Ala  Asn Gly Lys 
    1520                 1525                 1530             


Glu Ser  Asn Thr Phe Phe Gln  Val Glu Pro Asn Thr  Lys Leu Phe 
    1535                 1540                 1545             


Pro Ala  Val Phe Val Leu Pro  Thr His Gln Asn Val  Ile Gln Phe 
    1550                 1555                 1560             


Glu Leu  Gly Lys Gln Lys Asn  Ile Met Pro Leu Ser  Ala Ala Met 
    1565                 1570                 1575             


Phe Gln  Ser Glu Arg Lys Asn  Pro Ala Pro Gln Cys  Pro Pro Arg 
    1580                 1585                 1590             


Leu Glu  Met Gln Met Leu Met  Pro Val Ser Trp Ser  Arg Met Pro 
    1595                 1600                 1605             


Asn His  Phe Leu Gln Val Glu  Thr Arg Arg Ala Gly  Glu Arg Leu 
    1610                 1615                 1620             


Gly Trp  Ala Val Gln Cys Gln  Glu Pro Leu Thr Met  Met Ala Leu 
    1625                 1630                 1635             


His Ile  Pro Glu Glu Asn Arg  Cys Met Asp Ile Leu  Glu Leu Ser 
    1640                 1645                 1650             


Glu Arg  Leu Asp Leu Gln Arg  Phe His Ser His Thr  Leu Arg Leu 
    1655                 1660                 1665             


Tyr Arg  Ala Val Cys Ala Leu  Gly Asn Asn Arg Val  Ala His Ala 
    1670                 1675                 1680             


Leu Cys  Ser His Val Asp Gln  Ala Gln Leu Leu His  Ala Leu Glu 
    1685                 1690                 1695             


Asp Ala  His Leu Pro Gly Pro  Leu Arg Ala Gly Tyr  Tyr Asp Leu 
    1700                 1705                 1710             


Leu Ile  Ser Ile His Leu Glu  Ser Ala Cys Arg Ser  Arg Arg Ser 
    1715                 1720                 1725             


Met Leu  Ser Glu Tyr Ile Val  Pro Leu Thr Pro Glu  Thr Arg Ala 
    1730                 1735                 1740             


Ile Thr  Leu Phe Pro Pro Gly  Arg Ser Thr Glu Asn  Gly His Pro 
    1745                 1750                 1755             


Arg His  Gly Leu Pro Gly Val  Gly Val Thr Thr Ser  Leu Arg Pro 
    1760                 1765                 1770             


Pro His  His Phe Ser Pro Pro  Cys Phe Val Ala Ala  Leu Pro Ala 
    1775                 1780                 1785             


Ala Gly  Ala Ala Glu Ala Pro  Ala Arg Leu Ser Pro  Ala Ile Pro 
    1790                 1795                 1800             


Leu Glu  Ala Leu Arg Asp Lys  Ala Leu Arg Met Leu  Gly Glu Ala 
    1805                 1810                 1815             


Val Arg  Asp Gly Gly Gln His  Ala Arg Asp Pro Val  Gly Gly Ser 
    1820                 1825                 1830             


Val Glu  Phe Gln Phe Val Pro  Val Leu Lys Leu Val  Ser Thr Leu 
    1835                 1840                 1845             


Leu Val  Met Gly Ile Phe Gly  Asp Glu Asp Val Lys  Gln Ile Leu 
    1850                 1855                 1860             


Lys Met  Ile Glu Pro Glu Val  Phe Thr Glu Glu Glu  Glu Glu Glu 
    1865                 1870                 1875             


Asp Glu  Glu Glu Glu Gly Glu  Glu Glu Asp Glu Glu  Glu Lys Glu 
    1880                 1885                 1890             


Glu Asp  Glu Glu Glu Thr Ala  Gln Glu Lys Glu Asp  Glu Glu Lys 
    1895                 1900                 1905             


Glu Glu  Glu Glu Ala Ala Glu  Gly Glu Lys Glu Glu  Gly Leu Glu 
    1910                 1915                 1920             


Glu Gly  Leu Leu Gln Met Lys  Leu Pro Glu Ser Val  Lys Leu Gln 
    1925                 1930                 1935             


Met Cys  His Leu Leu Glu Tyr  Phe Cys Asp Gln Glu  Leu Gln His 
    1940                 1945                 1950             


Arg Val  Glu Ser Leu Ala Ala  Phe Ala Glu Arg Tyr  Val Asp Lys 
    1955                 1960                 1965             


Leu Gln  Ala Asn Gln Arg Ser  Arg Tyr Gly Leu Leu  Ile Lys Ala 
    1970                 1975                 1980             


Phe Ser  Met Thr Ala Ala Glu  Thr Ala Arg Arg Thr  Arg Glu Phe 
    1985                 1990                 1995             


Arg Ser  Pro Pro Gln Glu Gln  Ile Asn Met Leu Leu  Gln Phe Lys 
    2000                 2005                 2010             


Asp Gly  Thr Asp Glu Glu Asp  Cys Pro Leu Pro Glu  Glu Ile Arg 
    2015                 2020                 2025             


Gln Asp  Leu Leu Asp Phe His  Gln Asp Leu Leu Ala  His Cys Gly 
    2030                 2035                 2040             


Ile Gln  Leu Asp Gly Glu Glu  Glu Glu Pro Glu Glu  Glu Thr Thr 
    2045                 2050                 2055             


Leu Gly  Ser Arg Leu Met Ser  Leu Leu Glu Lys Val  Arg Leu Val 
    2060                 2065                 2070             


Lys Lys  Lys Glu Glu Lys Pro  Glu Glu Glu Arg Ser  Ala Glu Glu 
    2075                 2080                 2085             


Ser Lys  Pro Arg Ser Leu Gln  Glu Leu Val Ser His  Met Val Val 
    2090                 2095                 2100             


Arg Trp  Ala Gln Glu Asp Phe  Val Gln Ser Pro Glu  Leu Val Arg 
    2105                 2110                 2115             


Ala Met  Phe Ser Leu Leu His  Arg Gln Tyr Asp Gly  Leu Gly Glu 
    2120                 2125                 2130             


Leu Leu  Arg Ala Leu Pro Arg  Ala Tyr Thr Ile Ser  Pro Ser Ser 
    2135                 2140                 2145             


Val Glu  Asp Thr Met Ser Leu  Leu Glu Cys Leu Gly  Gln Ile Arg 
    2150                 2155                 2160             


Ser Leu  Leu Ile Val Gln Met  Gly Pro Gln Glu Glu  Asn Leu Met 
    2165                 2170                 2175             


Ile Gln  Ser Ile Gly Asn Ile  Met Asn Asn Lys Val  Phe Tyr Gln 
    2180                 2185                 2190             


His Pro  Asn Leu Met Arg Ala  Leu Gly Met His Glu  Thr Val Met 
    2195                 2200                 2205             


Glu Val  Met Val Asn Val Leu  Gly Gly Gly Glu Ser  Lys Glu Ile 
    2210                 2215                 2220             


Arg Phe  Pro Lys Met Val Thr  Ser Cys Cys Arg Phe  Leu Cys Tyr 
    2225                 2230                 2235             


Phe Cys  Arg Ile Ser Arg Gln  Asn Gln Arg Ser Met  Phe Asp His 
    2240                 2245                 2250             


Leu Ser  Tyr Leu Leu Glu Asn  Ser Gly Ile Gly Leu  Gly Met Gln 
    2255                 2260                 2265             


Gly Ser  Thr Pro Leu Asp Val  Ala Ala Ala Ser Val  Ile Asp Asn 
    2270                 2275                 2280             


Asn Glu  Leu Ala Leu Ala Leu  Gln Glu Gln Asp Leu  Glu Lys Val 
    2285                 2290                 2295             


Val Ser  Tyr Leu Ala Gly Cys  Gly Leu Gln Ser Cys  Pro Met Leu 
    2300                 2305                 2310             


Val Ala  Lys Gly Tyr Pro Asp  Ile Gly Trp Asn Pro  Cys Gly Gly 
    2315                 2320                 2325             


Glu Arg  Tyr Leu Asp Phe Leu  Arg Phe Ala Val Phe  Val Asn Gly 
    2330                 2335                 2340             


Glu Ser  Val Glu Glu Asn Ala  Asn Val Val Val Arg  Leu Leu Ile 
    2345                 2350                 2355             


Arg Lys  Pro Glu Cys Phe Gly  Pro Ala Leu Arg Gly  Glu Gly Gly 
    2360                 2365                 2370             


Ser Gly  Leu Leu Ala Ala Ile  Glu Glu Ala Ile Arg  Ile Ser Glu 
    2375                 2380                 2385             


Asp Pro  Ala Arg Asp Gly Pro  Gly Ile Arg Arg Asp  Arg Arg Arg 
    2390                 2395                 2400             


Glu His  Phe Gly Glu Glu Pro  Pro Glu Glu Asn Arg  Val His Leu 
    2405                 2410                 2415             


Gly His  Ala Ile Met Ser Phe  Tyr Ala Ala Leu Ile  Asp Leu Leu 
    2420                 2425                 2430             


Gly Arg  Cys Ala Pro Glu Met  His Leu Ile Gln Ala  Gly Lys Gly 
    2435                 2440                 2445             


Glu Ala  Leu Arg Ile Arg Ala  Ile Leu Arg Ser Leu  Val Pro Leu 
    2450                 2455                 2460             


Glu Asp  Leu Val Gly Ile Ile  Ser Leu Pro Leu Gln  Ile Pro Thr 
    2465                 2470                 2475             


Leu Gly  Lys Asp Gly Ala Leu  Val Gln Pro Lys Met  Ser Ala Ser 
    2480                 2485                 2490             


Phe Val  Pro Asp His Lys Ala  Ser Met Val Leu Phe  Leu Asp Arg 
    2495                 2500                 2505             


Val Tyr  Gly Ile Glu Asn Gln  Asp Phe Leu Leu His  Val Leu Asp 
    2510                 2515                 2520             


Val Gly  Phe Leu Pro Asp Met  Arg Ala Ala Ala Ser  Leu Asp Thr 
    2525                 2530                 2535             


Ala Thr  Phe Ser Thr Thr Glu  Met Ala Leu Ala Leu  Asn Arg Tyr 
    2540                 2545                 2550             


Leu Cys  Leu Ala Val Leu Pro  Leu Ile Thr Lys Cys  Ala Pro Leu 
    2555                 2560                 2565             


Phe Ala  Gly Thr Glu His Arg  Ala Ile Met Val Asp  Ser Met Leu 
    2570                 2575                 2580             


His Thr  Val Tyr Arg Leu Ser  Arg Gly Arg Ser Leu  Thr Lys Ala 
    2585                 2590                 2595             


Gln Arg  Asp Val Ile Glu Asp  Cys Leu Met Ser Leu  Cys Arg Tyr 
    2600                 2605                 2610             


Ile Arg  Pro Ser Met Leu Gln  His Leu Leu Arg Arg  Leu Val Phe 
    2615                 2620                 2625             


Asp Val  Pro Ile Leu Asn Glu  Phe Ala Lys Met Pro  Leu Lys Leu 
    2630                 2635                 2640             


Leu Thr  Asn His Tyr Glu Arg  Cys Trp Lys Tyr Tyr  Cys Leu Pro 
    2645                 2650                 2655             


Thr Gly  Trp Ala Asn Phe Gly  Val Thr Ser Glu Glu  Glu Leu His 
    2660                 2665                 2670             


Leu Thr  Arg Lys Leu Phe Trp  Gly Ile Phe Asp Ser  Leu Ala His 
    2675                 2680                 2685             


Lys Lys  Tyr Asp Pro Glu Leu  Tyr Arg Met Ala Met  Pro Cys Leu 
    2690                 2695                 2700             


Cys Ala  Ile Ala Gly Ala Leu  Pro Pro Asp Tyr Val  Asp Ala Ser 
    2705                 2710                 2715             


Tyr Ser  Ser Lys Ala Glu Lys  Lys Ala Thr Val Asp  Ala Glu Gly 
    2720                 2725                 2730             


Asn Phe  Asp Pro Arg Pro Val  Glu Thr Leu Asn Val  Ile Ile Pro 
    2735                 2740                 2745             


Glu Lys  Leu Asp Ser Phe Ile  Asn Lys Phe Ala Glu  Tyr Thr His 
    2750                 2755                 2760             


Glu Lys  Trp Ala Phe Asp Lys  Ile Gln Asn Asn Trp  Ser Tyr Gly 
    2765                 2770                 2775             


Glu Asn  Ile Asp Glu Glu Leu  Lys Thr His Pro Met  Leu Arg Pro 
    2780                 2785                 2790             


Tyr Lys  Thr Phe Ser Glu Lys  Asp Lys Glu Ile Tyr  Arg Trp Pro 
    2795                 2800                 2805             


Ile Lys  Glu Ser Leu Lys Ala  Met Ile Ala Trp Glu  Trp Thr Ile 
    2810                 2815                 2820             


Glu Lys  Ala Arg Glu Gly Glu  Glu Glu Lys Thr Glu  Lys Lys Lys 
    2825                 2830                 2835             


Thr Arg  Lys Ile Ser Gln Ser  Ala Gln Thr Tyr Asp  Pro Arg Glu 
    2840                 2845                 2850             


Gly Tyr  Asn Pro Gln Pro Pro  Asp Leu Ser Ala Val  Thr Leu Ser 
    2855                 2860                 2865             


Arg Glu  Leu Gln Ala Met Ala  Glu Gln Leu Ala Glu  Asn Tyr His 
    2870                 2875                 2880             


Asn Thr  Trp Gly Arg Lys Lys  Lys Gln Glu Leu Glu  Ala Lys Gly 
    2885                 2890                 2895             


Gly Gly  Thr His Pro Leu Leu  Val Pro Tyr Asp Thr  Leu Thr Ala 
    2900                 2905                 2910             


Lys Glu  Lys Ala Arg Asp Arg  Glu Lys Ala Gln Glu  Leu Leu Lys 
    2915                 2920                 2925             


Phe Leu  Gln Met Asn Gly Tyr  Ala Val Thr Arg Gly  Leu Lys Asp 
    2930                 2935                 2940             


Met Glu  Leu Asp Ser Ser Ser  Ile Glu Lys Arg Phe  Ala Phe Gly 
    2945                 2950                 2955             


Phe Leu  Gln Gln Leu Leu Arg  Trp Met Asp Ile Ser  Gln Glu Phe 
    2960                 2965                 2970             


Ile Ala  His Leu Glu Ala Val  Val Ser Ser Gly Arg  Val Glu Lys 
    2975                 2980                 2985             


Ser Pro  His Glu Gln Glu Ile  Lys Phe Phe Ala Lys  Ile Leu Leu 
    2990                 2995                 3000             


Pro Leu  Ile Asn Gln Tyr Phe  Thr Asn His Cys Leu  Tyr Phe Leu 
    3005                 3010                 3015             


Ser Thr  Pro Ala Lys Val Leu  Gly Ser Gly Gly His  Ala Ser Asn 
    3020                 3025                 3030             


Lys Glu  Lys Glu Met Ile Thr  Ser Leu Phe Cys Lys  Leu Ala Ala 
    3035                 3040                 3045             


Leu Val  Arg His Arg Val Ser  Leu Phe Gly Thr Asp  Ala Pro Ala 
    3050                 3055                 3060             


Val Val  Asn Cys Leu His Ile  Leu Ala Arg Ser Leu  Asp Ala Arg 
    3065                 3070                 3075             


Thr Val  Met Lys Ser Gly Pro  Glu Ile Val Lys Ala  Gly Leu Arg 
    3080                 3085                 3090             


Ser Phe  Phe Glu Ser Ala Ser  Glu Asp Ile Glu Lys  Met Val Glu 
    3095                 3100                 3105             


Asn Leu  Arg Leu Gly Lys Val  Ser Gln Ala Arg Thr  Gln Val Lys 
    3110                 3115                 3120             


Gly Val  Gly Gln Asn Leu Thr  Tyr Thr Thr Val Ala  Leu Leu Pro 
    3125                 3130                 3135             


Val Leu  Thr Thr Leu Phe Gln  His Ile Ala Gln His  Gln Phe Gly 
    3140                 3145                 3150             


Asp Asp  Val Ile Leu Asp Asp  Val Gln Val Ser Cys  Tyr Arg Thr 
    3155                 3160                 3165             


Leu Cys  Ser Ile Tyr Ser Leu  Gly Thr Thr Lys Asn  Thr Tyr Val 
    3170                 3175                 3180             


Glu Lys  Leu Arg Pro Ala Leu  Gly Glu Cys Leu Ala  Arg Leu Ala 
    3185                 3190                 3195             


Ala Ala  Met Pro Val Ala Phe  Leu Glu Pro Gln Leu  Asn Glu Tyr 
    3200                 3205                 3210             


Asn Ala  Cys Ser Val Tyr Thr  Thr Lys Ser Pro Arg  Glu Arg Ala 
    3215                 3220                 3225             


Ile Leu  Gly Leu Pro Asn Ser  Val Glu Glu Met Cys  Pro Asp Ile 
    3230                 3235                 3240             


Pro Val  Leu Glu Arg Leu Met  Ala Asp Ile Gly Gly  Leu Ala Glu 
    3245                 3250                 3255             


Ser Gly  Ala Arg Tyr Thr Glu  Met Pro His Val Ile  Glu Ile Thr 
    3260                 3265                 3270             


Leu Pro  Met Leu Cys Ser Tyr  Leu Pro Arg Trp Trp  Glu Arg Gly 
    3275                 3280                 3285             


Pro Glu  Ala Pro Pro Ser Ala  Leu Pro Ala Gly Ala  Pro Pro Pro 
    3290                 3295                 3300             


Cys Thr  Ala Val Thr Ser Asp  His Leu Asn Ser Leu  Leu Gly Asn 
    3305                 3310                 3315             


Ile Leu  Arg Ile Ile Val Asn  Asn Leu Gly Ile Asp  Glu Ala Ser 
    3320                 3325                 3330             


Trp Met  Lys Arg Leu Ala Val  Phe Ala Gln Pro Ile  Val Ser Arg 
    3335                 3340                 3345             


Ala Arg  Pro Glu Leu Leu Gln  Ser His Phe Ile Pro  Thr Ile Gly 
    3350                 3355                 3360             


Arg Leu  Arg Lys Arg Ala Gly  Lys Val Val Ser Glu  Glu Glu Gln 
    3365                 3370                 3375             


Leu Arg  Leu Glu Ala Lys Ala  Glu Ala Gln Glu Gly  Glu Leu Leu 
    3380                 3385                 3390             


Val Arg  Asp Glu Phe Ser Val  Leu Cys Arg Asp Leu  Tyr Ala Leu 
    3395                 3400                 3405             


Tyr Pro  Leu Leu Ile Arg Tyr  Val Asp Asn Asn Arg  Ala Gln Trp 
    3410                 3415                 3420             


Leu Thr  Glu Pro Asn Pro Ser  Ala Glu Glu Leu Phe  Arg Met Val 
    3425                 3430                 3435             


Gly Glu  Ile Phe Ile Tyr Trp  Ser Lys Ser His Asn  Phe Lys Arg 
    3440                 3445                 3450             


Glu Glu  Gln Asn Phe Val Val  Gln Asn Glu Ile Asn  Asn Met Ser 
    3455                 3460                 3465             


Phe Leu  Thr Ala Asp Asn Lys  Ser Lys Met Ala Lys  Ala Gly Asp 
    3470                 3475                 3480             


Ile Gln  Ser Gly Gly Ser Asp  Gln Glu Arg Thr Lys  Lys Lys Arg 
    3485                 3490                 3495             


Arg Gly  Asp Arg Tyr Ser Val  Gln Thr Ser Leu Ile  Val Ala Thr 
    3500                 3505                 3510             


Leu Lys  Lys Met Leu Pro Ile  Gly Leu Asn Met Cys  Ala Pro Thr 
    3515                 3520                 3525             


Asp Gln  Asp Leu Ile Thr Leu  Ala Lys Thr Arg Tyr  Ala Leu Lys 
    3530                 3535                 3540             


Asp Thr  Asp Glu Glu Val Arg  Glu Phe Leu His Asn  Asn Leu His 
    3545                 3550                 3555             


Leu Gln  Gly Lys Val Glu Gly  Ser Pro Ser Leu Arg  Trp Gln Met 
    3560                 3565                 3570             


Ala Leu  Tyr Arg Gly Val Pro  Gly Arg Glu Glu Asp  Ala Asp Asp 
    3575                 3580                 3585             


Pro Glu  Lys Ile Val Arg Arg  Val Gln Glu Val Ser  Ala Val Leu 
    3590                 3595                 3600             


Tyr Tyr  Leu Asp Gln Thr Glu  His Pro Tyr Lys Ser  Lys Lys Ala 
    3605                 3610                 3615             


Val Trp  His Lys Leu Leu Ser  Lys Gln Arg Arg Arg  Ala Val Val 
    3620                 3625                 3630             


Ala Cys  Phe Arg Met Thr Pro  Leu Tyr Asn Leu Pro  Thr His Arg 
    3635                 3640                 3645             


Ala Cys  Asn Met Phe Leu Glu  Ser Tyr Lys Ala Ala  Trp Ile Leu 
    3650                 3655                 3660             


Thr Glu  Asp His Ser Phe Glu  Asp Arg Met Ile Asp  Asp Leu Ser 
    3665                 3670                 3675             


Lys Ala  Gly Glu Gln Glu Glu  Glu Glu Glu Glu Val  Glu Glu Lys 
    3680                 3685                 3690             


Lys Pro  Asp Pro Leu His Gln  Leu Val Leu His Phe  Ser Arg Thr 
    3695                 3700                 3705             


Ala Leu  Thr Glu Lys Ser Lys  Leu Asp Glu Asp Tyr  Leu Tyr Met 
    3710                 3715                 3720             


Ala Tyr  Ala Asp Ile Met Ala  Lys Ser Cys His Leu  Glu Glu Gly 
    3725                 3730                 3735             


Gly Glu  Asn Gly Glu Ala Glu  Glu Glu Val Glu Val  Ser Phe Glu 
    3740                 3745                 3750             


Glu Lys  Gln Met Glu Lys Gln  Arg Leu Leu Tyr Gln  Gln Ala Arg 
    3755                 3760                 3765             


Leu His  Thr Arg Gly Ala Ala  Glu Met Val Leu Gln  Met Ile Ser 
    3770                 3775                 3780             


Ala Cys  Lys Gly Glu Thr Gly  Ala Met Val Ser Ser  Thr Leu Lys 
    3785                 3790                 3795             


Leu Gly  Ile Ser Ile Leu Asn  Gly Gly Asn Ala Glu  Val Gln Gln 
    3800                 3805                 3810             


Lys Met  Leu Asp Tyr Leu Lys  Asp Lys Lys Glu Val  Gly Phe Phe 
    3815                 3820                 3825             


Gln Ser  Ile Gln Ala Leu Met  Gln Thr Cys Ser Val  Leu Asp Leu 
    3830                 3835                 3840             


Asn Ala  Phe Glu Arg Gln Asn  Lys Ala Glu Gly Leu  Gly Met Val 
    3845                 3850                 3855             


Asn Glu  Asp Gly Thr Val Ile  Asn Arg Gln Asn Gly  Glu Lys Val 
    3860                 3865                 3870             


Met Ala  Asp Asp Glu Phe Thr  Gln Asp Leu Phe Arg  Phe Leu Gln 
    3875                 3880                 3885             


Leu Leu  Cys Glu Gly His Asn  Asn Asp Phe Gln Asn  Tyr Leu Arg 
    3890                 3895                 3900             


Thr Gln  Thr Gly Asn Thr Thr  Thr Ile Asn Ile Ile  Ile Cys Thr 
    3905                 3910                 3915             


Val Asp  Tyr Leu Leu Arg Leu  Gln Glu Ser Ile Ser  Asp Phe Tyr 
    3920                 3925                 3930             


Trp Tyr  Tyr Ser Gly Lys Asp  Val Ile Glu Glu Gln  Gly Lys Arg 
    3935                 3940                 3945             


Asn Phe  Ser Lys Ala Met Ser  Val Ala Lys Gln Val  Phe Asn Ser 
    3950                 3955                 3960             


Leu Thr  Glu Tyr Ile Gln Gly  Pro Cys Thr Gly Asn  Gln Gln Ser 
    3965                 3970                 3975             


Leu Ala  His Ser Arg Leu Trp  Asp Ala Val Val Gly  Phe Leu His 
    3980                 3985                 3990             


Val Phe  Ala His Met Met Met  Lys Leu Ala Gln Asp  Ser Ser Gln 
    3995                 4000                 4005             


Ile Glu  Leu Leu Lys Glu Leu  Leu Asp Leu Gln Lys  Asp Met Val 
    4010                 4015                 4020             


Val Met  Leu Leu Ser Leu Leu  Glu Gly Asn Val Val  Asn Gly Met 
    4025                 4030                 4035             


Ile Ala  Arg Gln Met Val Asp  Met Leu Val Glu Ser  Ser Ser Asn 
    4040                 4045                 4050             


Val Glu  Met Ile Leu Lys Phe  Phe Asp Met Phe Leu  Lys Leu Lys 
    4055                 4060                 4065             


Asp Ile  Val Gly Ser Glu Ala  Phe Gln Asp Tyr Val  Thr Asp Pro 
    4070                 4075                 4080             


Arg Gly  Leu Ile Ser Lys Lys  Asp Phe Gln Lys Ala  Met Asp Ser 
    4085                 4090                 4095             


Gln Lys  Gln Phe Ser Gly Pro  Glu Ile Gln Phe Leu  Leu Ser Cys 
    4100                 4105                 4110             


Ser Glu  Ala Asp Glu Asn Glu  Met Ile Asn Cys Glu  Glu Phe Ala 
    4115                 4120                 4125             


Asn Arg  Phe Gln Glu Pro Ala  Arg Asp Ile Gly Phe  Asn Val Ala 
    4130                 4135                 4140             


Val Leu  Leu Thr Asn Leu Ser  Glu His Val Pro His  Asp Pro Arg 
    4145                 4150                 4155             


Leu His  Asn Phe Leu Glu Leu  Ala Glu Ser Ile Leu  Glu Tyr Phe 
    4160                 4165                 4170             


Arg Pro  Tyr Leu Gly Arg Ile  Glu Ile Met Gly Ala  Ser Arg Arg 
    4175                 4180                 4185             


Ile Glu  Arg Ile Tyr Phe Glu  Ile Ser Glu Thr Asn  Arg Ala Gln 
    4190                 4195                 4200             


Trp Glu  Met Pro Gln Val Lys  Glu Ser Lys Arg Gln  Phe Ile Phe 
    4205                 4210                 4215             


Asp Val  Val Asn Glu Gly Gly  Glu Ala Glu Lys Met  Glu Leu Phe 
    4220                 4225                 4230             


Val Ser  Phe Cys Glu Asp Thr  Ile Phe Glu Met Gln  Ile Ala Ala 
    4235                 4240                 4245             


Gln Ile  Ser Glu Pro Glu Gly  Glu Pro Glu Thr Asp  Glu Asp Glu 
    4250                 4255                 4260             


Gly Ala  Gly Ala Ala Glu Ala  Gly Ala Glu Gly Ala  Glu Glu Gly 
    4265                 4270                 4275             


Ala Ala  Gly Leu Glu Gly Thr  Ala Ala Thr Ala Ala  Ala Gly Ala 
    4280                 4285                 4290             


Thr Ala  Arg Val Val Ala Ala  Ala Gly Arg Ala Leu  Arg Gly Leu 
    4295                 4300                 4305             


Ser Tyr  Arg Ser Leu Arg Arg  Arg Val Arg Arg Leu  Arg Arg Leu 
    4310                 4315                 4320             


Thr Ala  Arg Glu Ala Ala Thr  Ala Val Ala Ala Leu  Leu Trp Ala 
    4325                 4330                 4335             


Ala Val  Thr Arg Ala Gly Ala  Ala Gly Ala Gly Ala  Ala Ala Gly 
    4340                 4345                 4350             


Ala Leu  Gly Leu Leu Trp Gly  Ser Leu Phe Gly Gly  Gly Leu Val 
    4355                 4360                 4365             


Glu Gly  Ala Lys Lys Val Thr  Val Thr Glu Leu Leu  Ala Gly Met 
    4370                 4375                 4380             


Pro Asp  Pro Thr Ser Asp Glu  Val His Gly Glu Gln  Pro Ala Gly 
    4385                 4390                 4395             


Pro Gly  Gly Asp Ala Asp Gly  Glu Gly Ala Ser Glu  Gly Ala Gly 
    4400                 4405                 4410             


Asp Ala  Ala Glu Gly Ala Gly  Asp Glu Glu Glu Ala  Val His Glu 
    4415                 4420                 4425             


Ala Gly  Pro Gly Gly Ala Asp  Gly Ala Val Ala Val  Thr Asp Gly 
    4430                 4435                 4440             


Gly Pro  Phe Arg Pro Glu Gly  Ala Gly Gly Leu Gly  Asp Met Gly 
    4445                 4450                 4455             


Asp Thr  Thr Pro Ala Glu Pro  Pro Thr Pro Glu Gly  Ser Pro Ile 
    4460                 4465                 4470             


Leu Lys  Arg Lys Leu Gly Val  Asp Gly Val Glu Glu  Glu Leu Pro 
    4475                 4480                 4485             


Pro Glu  Pro Glu Pro Glu Pro  Glu Pro Glu Leu Glu  Pro Glu Lys 
    4490                 4495                 4500             


Ala Asp  Ala Glu Asn Gly Glu  Lys Glu Glu Val Pro  Glu Pro Thr 
    4505                 4510                 4515             


Pro Glu  Pro Pro Lys Lys Gln  Ala Pro Pro Ser Pro  Pro Pro Lys 
    4520                 4525                 4530             


Lys Glu  Glu Ala Gly Gly Glu  Phe Trp Gly Glu Leu  Glu Val Gln 
    4535                 4540                 4545             


Arg Val  Lys Phe Leu Asn Tyr  Leu Ser Arg Asn Phe  Tyr Thr Leu 
    4550                 4555                 4560             


Arg Phe  Leu Ala Leu Phe Leu  Ala Phe Ala Ile Asn  Phe Ile Leu 
    4565                 4570                 4575             


Leu Phe  Tyr Lys Val Ser Asp  Ser Pro Pro Gly Glu  Asp Asp Met 
    4580                 4585                 4590             


Glu Gly  Ser Ala Ala Gly Asp  Val Ser Gly Ala Gly  Ser Gly Gly 
    4595                 4600                 4605             


Ser Ser  Gly Trp Gly Leu Gly  Ala Gly Glu Glu Ala  Glu Gly Asp 
    4610                 4615                 4620             


Glu Asp  Glu Asn Met Val Tyr  Tyr Phe Leu Glu Glu  Ser Thr Gly 
    4625                 4630                 4635             


Tyr Met  Glu Pro Ala Leu Arg  Cys Leu Ser Leu Leu  His Thr Leu 
    4640                 4645                 4650             


Val Ala  Phe Leu Cys Ile Ile  Gly Tyr Asn Cys Leu  Lys Val Pro 
    4655                 4660                 4665             


Leu Val  Ile Phe Lys Arg Glu  Lys Glu Leu Ala Arg  Lys Leu Glu 
    4670                 4675                 4680             


Phe Asp  Gly Leu Tyr Ile Thr  Glu Gln Pro Glu Asp  Asp Asp Val 
    4685                 4690                 4695             


Lys Gly  Gln Trp Asp Arg Leu  Val Leu Asn Thr Pro  Ser Phe Pro 
    4700                 4705                 4710             


Ser Asn  Tyr Trp Asp Lys Phe  Val Lys Arg Lys Val  Leu Asp Lys 
    4715                 4720                 4725             


His Gly  Asp Ile Tyr Gly Arg  Glu Arg Ile Ala Glu  Leu Leu Gly 
    4730                 4735                 4740             


Met Asp  Leu Ala Thr Leu Glu  Ile Thr Ala His Asn  Glu Arg Lys 
    4745                 4750                 4755             


Pro Asn  Pro Pro Pro Gly Leu  Leu Thr Trp Leu Met  Ser Ile Asp 
    4760                 4765                 4770             


Val Lys  Tyr Gln Ile Trp Lys  Phe Gly Val Ile Phe  Thr Asp Asn 
    4775                 4780                 4785             


Ser Phe  Leu Tyr Leu Gly Trp  Tyr Met Val Met Ser  Leu Leu Gly 
    4790                 4795                 4800             


His Tyr  Asn Asn Phe Phe Phe  Ala Ala His Leu Leu  Asp Ile Ala 
    4805                 4810                 4815             


Met Gly  Val Lys Thr Leu Arg  Thr Ile Leu Ser Ser  Val Thr His 
    4820                 4825                 4830             


Asn Gly  Lys Gln Leu Val Met  Thr Val Gly Leu Leu  Ala Val Val 
    4835                 4840                 4845             


Val Tyr  Leu Tyr Thr Val Val  Ala Phe Asn Phe Phe  Arg Lys Phe 
    4850                 4855                 4860             


Tyr Asn  Lys Ser Glu Asp Glu  Asp Glu Pro Asp Met  Lys Cys Asp 
    4865                 4870                 4875             


Asp Met  Met Thr Cys Tyr Leu  Phe His Met Tyr Val  Gly Val Arg 
    4880                 4885                 4890             


Ala Gly  Gly Gly Ile Gly Asp  Glu Ile Glu Asp Pro  Ala Gly Asp 
    4895                 4900                 4905             


Glu Tyr  Glu Leu Tyr Arg Val  Val Phe Asp Ile Thr  Phe Phe Phe 
    4910                 4915                 4920             


Phe Val  Ile Val Ile Leu Leu  Ala Ile Ile Gln Gly  Leu Ile Ile 
    4925                 4930                 4935             


Asp Ala  Phe Gly Glu Leu Arg  Asp Gln Gln Glu Gln  Val Lys Glu 
    4940                 4945                 4950             


Asp Met  Glu Thr Lys Cys Phe  Ile Cys Gly Ile Gly  Ser Asp Tyr 
    4955                 4960                 4965             


Phe Asp  Thr Thr Pro His Gly  Phe Glu Thr His Thr  Leu Glu Glu 
    4970                 4975                 4980             


His Asn  Leu Ala Asn Tyr Met  Phe Phe Leu Met Tyr  Leu Ile Asn 
    4985                 4990                 4995             


Lys Asp  Glu Thr Glu His Thr  Gly Gln Glu Ser Tyr  Val Trp Lys 
    5000                 5005                 5010             


Met Tyr  Gln Glu Arg Cys Trp  Asp Phe Phe Pro Ala  Gly Asp Cys 
    5015                 5020                 5025             


Phe Arg  Lys Gln Tyr Glu Asp  Gln Leu Ser 
    5030                 5035             


<210>  158
<211>  631
<212>  PRT
<213>  Homo sapiens

<400>  158

Met Pro Arg Tyr Gly Ala Ser Leu Arg Gln Ser Cys Pro Arg Ser Gly 
1               5                   10                  15      


Arg Glu Gln Gly Gln Asp Gly Thr Ala Gly Ala Pro Gly Leu Leu Trp 
            20                  25                  30          


Met Gly Leu Val Leu Ala Leu Ala Leu Ala Leu Ala Leu Ala Leu Ala 
        35                  40                  45              


Leu Ser Asp Ser Arg Val Leu Trp Ala Pro Ala Glu Ala His Pro Leu 
    50                  55                  60                  


Ser Pro Gln Gly His Pro Ala Arg Leu His Arg Ile Val Pro Arg Leu 
65                  70                  75                  80  


Arg Asp Val Phe Gly Trp Gly Asn Leu Thr Cys Pro Ile Cys Lys Gly 
                85                  90                  95      


Leu Phe Thr Ala Ile Asn Leu Gly Leu Lys Lys Glu Pro Asn Val Ala 
            100                 105                 110         


Arg Val Gly Ser Val Ala Ile Lys Leu Cys Asn Leu Leu Lys Ile Ala 
        115                 120                 125             


Pro Pro Ala Val Cys Gln Ser Ile Val His Leu Phe Glu Asp Asp Met 
    130                 135                 140                 


Val Glu Val Trp Arg Arg Ser Val Leu Ser Pro Ser Glu Ala Cys Gly 
145                 150                 155                 160 


Leu Leu Leu Gly Ser Thr Cys Gly His Trp Asp Ile Phe Ser Ser Trp 
                165                 170                 175     


Asn Ile Ser Leu Pro Thr Val Pro Lys Pro Pro Pro Lys Pro Pro Ser 
            180                 185                 190         


Pro Pro Ala Pro Gly Ala Pro Val Ser Arg Ile Leu Phe Leu Thr Asp 
        195                 200                 205             


Leu His Trp Asp His Asp Tyr Leu Glu Gly Thr Asp Pro Asp Cys Ala 
    210                 215                 220                 


Asp Pro Leu Cys Cys Arg Arg Gly Ser Gly Leu Pro Pro Ala Ser Arg 
225                 230                 235                 240 


Pro Gly Ala Gly Tyr Trp Gly Glu Tyr Ser Lys Cys Asp Leu Pro Leu 
                245                 250                 255     


Arg Thr Leu Glu Ser Leu Leu Ser Gly Leu Gly Pro Ala Gly Pro Phe 
            260                 265                 270         


Asp Met Val Tyr Trp Thr Gly Asp Ile Pro Ala His Asp Val Trp His 
        275                 280                 285             


Gln Thr Arg Gln Asp Gln Leu Arg Ala Leu Thr Thr Val Thr Ala Leu 
    290                 295                 300                 


Val Arg Lys Phe Leu Gly Pro Val Pro Val Tyr Pro Ala Val Gly Asn 
305                 310                 315                 320 


His Glu Ser Thr Pro Val Asn Ser Phe Pro Pro Pro Phe Ile Glu Gly 
                325                 330                 335     


Asn His Ser Ser Arg Trp Leu Tyr Glu Ala Met Ala Lys Ala Trp Glu 
            340                 345                 350         


Pro Trp Leu Pro Ala Glu Ala Leu Arg Thr Leu Arg Ile Gly Gly Phe 
        355                 360                 365             


Tyr Ala Leu Ser Pro Tyr Pro Gly Leu Arg Leu Ile Ser Leu Asn Met 
    370                 375                 380                 


Asn Phe Cys Ser Arg Glu Asn Phe Trp Leu Leu Ile Asn Ser Thr Asp 
385                 390                 395                 400 


Pro Ala Gly Gln Leu Gln Trp Leu Val Gly Glu Leu Gln Ala Ala Glu 
                405                 410                 415     


Asp Arg Gly Asp Lys Val His Ile Ile Gly His Ile Pro Pro Gly His 
            420                 425                 430         


Cys Leu Lys Ser Trp Ser Trp Asn Tyr Tyr Arg Ile Val Ala Arg Tyr 
        435                 440                 445             


Glu Asn Thr Leu Ala Ala Gln Phe Phe Gly His Thr His Val Asp Glu 
    450                 455                 460                 


Phe Glu Val Phe Tyr Asp Glu Glu Thr Leu Ser Arg Pro Leu Ala Val 
465                 470                 475                 480 


Ala Phe Leu Ala Pro Ser Ala Thr Thr Tyr Ile Gly Leu Asn Pro Gly 
                485                 490                 495     


Tyr Arg Val Tyr Gln Ile Asp Gly Asn Tyr Ser Gly Ser Ser His Val 
            500                 505                 510         


Val Leu Asp His Glu Thr Tyr Ile Leu Asn Leu Thr Gln Ala Asn Ile 
        515                 520                 525             


Pro Gly Ala Ile Pro His Trp Gln Leu Leu Tyr Arg Ala Arg Glu Thr 
    530                 535                 540                 


Tyr Gly Leu Pro Asn Thr Leu Pro Thr Ala Trp His Asn Leu Val Tyr 
545                 550                 555                 560 


Arg Met Arg Gly Asp Met Gln Leu Phe Gln Thr Phe Trp Phe Leu Tyr 
                565                 570                 575     


His Lys Gly His Pro Pro Ser Glu Pro Cys Gly Thr Pro Cys Arg Leu 
            580                 585                 590         


Ala Thr Leu Cys Ala Gln Leu Ser Ala Arg Ala Asp Ser Pro Ala Leu 
        595                 600                 605             


Cys Arg His Leu Met Pro Asp Gly Ser Leu Pro Glu Ala Gln Ser Leu 
    610                 615                 620                 


Trp Pro Arg Pro Leu Phe Cys 
625                 630     


<210>  159
<211>  933
<212>  PRT
<213>  Homo sapiens

<400>  159

Met Arg Ala Leu Ala Val Leu Ser Val Thr Leu Val Met Ala Cys Thr 
1               5                   10                  15      


Glu Ala Phe Phe Pro Phe Ile Ser Arg Gly Lys Glu Leu Leu Trp Gly 
            20                  25                  30          


Lys Pro Glu Glu Ser Arg Val Ser Ser Val Leu Glu Glu Ser Lys Arg 
        35                  40                  45              


Leu Val Asp Thr Ala Met Tyr Ala Thr Met Gln Arg Asn Leu Lys Lys 
    50                  55                  60                  


Arg Gly Ile Leu Ser Pro Ala Gln Leu Leu Ser Phe Ser Lys Leu Pro 
65                  70                  75                  80  


Glu Pro Thr Ser Gly Val Ile Ala Arg Ala Ala Glu Ile Met Glu Thr 
                85                  90                  95      


Ser Ile Gln Ala Met Lys Arg Lys Val Asn Leu Lys Thr Gln Gln Ser 
            100                 105                 110         


Gln His Pro Thr Asp Ala Leu Ser Glu Asp Leu Leu Ser Ile Ile Ala 
        115                 120                 125             


Asn Met Ser Gly Cys Leu Pro Tyr Met Leu Pro Pro Lys Cys Pro Asn 
    130                 135                 140                 


Thr Cys Leu Ala Asn Lys Tyr Arg Pro Ile Thr Gly Ala Cys Asn Asn 
145                 150                 155                 160 


Arg Asp His Pro Arg Trp Gly Ala Ser Asn Thr Ala Leu Ala Arg Trp 
                165                 170                 175     


Leu Pro Pro Val Tyr Glu Asp Gly Phe Ser Gln Pro Arg Gly Trp Asn 
            180                 185                 190         


Pro Gly Phe Leu Tyr Asn Gly Phe Pro Leu Pro Pro Val Arg Glu Val 
        195                 200                 205             


Thr Arg His Val Ile Gln Val Ser Asn Glu Val Val Thr Asp Asp Asp 
    210                 215                 220                 


Arg Tyr Ser Asp Leu Leu Met Ala Trp Gly Gln Tyr Ile Asp His Asp 
225                 230                 235                 240 


Ile Ala Phe Thr Pro Gln Ser Thr Ser Lys Ala Ala Phe Gly Gly Gly 
                245                 250                 255     


Ala Asp Cys Gln Met Thr Cys Glu Asn Gln Asn Pro Cys Phe Pro Ile 
            260                 265                 270         


Gln Leu Pro Glu Glu Ala Arg Pro Ala Ala Gly Thr Ala Cys Leu Pro 
        275                 280                 285             


Phe Tyr Arg Ser Ser Ala Ala Cys Gly Thr Gly Asp Gln Gly Ala Leu 
    290                 295                 300                 


Phe Gly Asn Leu Ser Thr Ala Asn Pro Arg Gln Gln Met Asn Gly Leu 
305                 310                 315                 320 


Thr Ser Phe Leu Asp Ala Ser Thr Val Tyr Gly Ser Ser Pro Ala Leu 
                325                 330                 335     


Glu Arg Gln Leu Arg Asn Trp Thr Ser Ala Glu Gly Leu Leu Arg Val 
            340                 345                 350         


His Ala Arg Leu Arg Asp Ser Gly Arg Ala Tyr Leu Pro Phe Val Pro 
        355                 360                 365             


Pro Arg Ala Pro Ala Ala Cys Ala Pro Glu Pro Gly Ile Pro Gly Glu 
    370                 375                 380                 


Thr Arg Gly Pro Cys Phe Leu Ala Gly Asp Gly Arg Ala Ser Glu Val 
385                 390                 395                 400 


Pro Ser Leu Thr Ala Leu His Thr Leu Trp Leu Arg Glu His Asn Arg 
                405                 410                 415     


Leu Ala Ala Ala Leu Lys Ala Leu Asn Ala His Trp Ser Ala Asp Ala 
            420                 425                 430         


Val Tyr Gln Glu Ala Arg Lys Val Val Gly Ala Leu His Gln Ile Ile 
        435                 440                 445             


Thr Leu Arg Asp Tyr Ile Pro Arg Ile Leu Gly Pro Glu Ala Phe Gln 
    450                 455                 460                 


Gln Tyr Val Gly Pro Tyr Glu Gly Tyr Asp Ser Thr Ala Asn Pro Thr 
465                 470                 475                 480 


Val Ser Asn Val Phe Ser Thr Ala Ala Phe Arg Phe Gly His Ala Thr 
                485                 490                 495     


Ile His Pro Leu Val Arg Arg Leu Asp Ala Ser Phe Gln Glu His Pro 
            500                 505                 510         


Asp Leu Pro Gly Leu Trp Leu His Gln Ala Phe Phe Ser Pro Trp Thr 
        515                 520                 525             


Leu Leu Arg Gly Gly Gly Leu Asp Pro Leu Ile Arg Gly Leu Leu Ala 
    530                 535                 540                 


Arg Pro Ala Lys Leu Gln Val Gln Asp Gln Leu Met Asn Glu Glu Leu 
545                 550                 555                 560 


Thr Glu Arg Leu Phe Val Leu Ser Asn Ser Ser Thr Leu Asp Leu Ala 
                565                 570                 575     


Ser Ile Asn Leu Gln Arg Gly Arg Asp His Gly Leu Pro Gly Tyr Asn 
            580                 585                 590         


Glu Trp Arg Glu Phe Cys Gly Leu Pro Arg Leu Glu Thr Pro Ala Asp 
        595                 600                 605             


Leu Ser Thr Ala Ile Ala Ser Arg Ser Val Ala Asp Lys Ile Leu Asp 
    610                 615                 620                 


Leu Tyr Lys His Pro Asp Asn Ile Asp Val Trp Leu Gly Gly Leu Ala 
625                 630                 635                 640 


Glu Asn Phe Leu Pro Arg Ala Arg Thr Gly Pro Leu Phe Ala Cys Leu 
                645                 650                 655     


Ile Gly Lys Gln Met Lys Ala Leu Arg Asp Gly Asp Trp Phe Trp Trp 
            660                 665                 670         


Glu Asn Ser His Val Phe Thr Asp Ala Gln Arg Arg Glu Leu Glu Lys 
        675                 680                 685             


His Ser Leu Ser Arg Val Ile Cys Asp Asn Thr Gly Leu Thr Arg Val 
    690                 695                 700                 


Pro Met Asp Ala Phe Gln Val Gly Lys Phe Pro Glu Asp Phe Glu Ser 
705                 710                 715                 720 


Cys Asp Ser Ile Thr Gly Met Asn Leu Glu Ala Trp Arg Glu Thr Phe 
                725                 730                 735     


Pro Gln Asp Asp Lys Cys Gly Phe Pro Glu Ser Val Glu Asn Gly Asp 
            740                 745                 750         


Phe Val His Cys Glu Glu Ser Gly Arg Arg Val Leu Val Tyr Ser Cys 
        755                 760                 765             


Arg His Gly Tyr Glu Leu Gln Gly Arg Glu Gln Leu Thr Cys Thr Gln 
    770                 775                 780                 


Glu Gly Trp Asp Phe Gln Pro Pro Leu Cys Lys Asp Val Asn Glu Cys 
785                 790                 795                 800 


Ala Asp Gly Ala His Pro Pro Cys His Ala Ser Ala Arg Cys Arg Asn 
                805                 810                 815     


Thr Lys Gly Gly Phe Gln Cys Leu Cys Ala Asp Pro Tyr Glu Leu Gly 
            820                 825                 830         


Asp Asp Gly Arg Thr Cys Val Asp Ser Gly Arg Leu Pro Arg Val Thr 
        835                 840                 845             


Trp Ile Ser Met Ser Leu Ala Ala Leu Leu Ile Gly Gly Phe Ala Gly 
    850                 855                 860                 


Leu Thr Ser Thr Val Ile Cys Arg Trp Thr Arg Thr Gly Thr Lys Ser 
865                 870                 875                 880 


Thr Leu Pro Ile Ser Glu Thr Gly Gly Gly Thr Pro Glu Leu Arg Cys 
                885                 890                 895     


Gly Lys His Gln Ala Val Gly Thr Ser Pro Gln Arg Ala Ala Ala Gln 
            900                 905                 910         


Asp Ser Glu Gln Glu Ser Ala Gly Met Glu Gly Arg Asp Thr His Arg 
        915                 920                 925             


Leu Pro Arg Ala Leu 
    930             


<210>  160
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  160

Met Ser Ala Pro Lys Leu Leu Ser Leu Gly Cys Ile Phe Phe Pro Leu 
1               5                   10                  15      


Leu Leu Phe Gln Gln Ala Arg Ala Gln Phe Pro Arg Gln Cys Ala Thr 
            20                  25                  30          


Val Glu Ala Leu Arg Ser Gly Met Cys Cys Pro Asp Leu Ser Pro Val 
        35                  40                  45              


Ser Gly Pro Gly Thr Asp Arg Cys Gly Ser Ser Ser Gly Arg Gly Arg 
    50                  55                  60                  


Cys Glu Ala Val Thr Ala Asp Ser Arg Pro His Ser Pro Gln Tyr Pro 
65                  70                  75                  80  


His Asp Gly Arg Asp Asp Arg Glu Val Trp Pro Leu Arg Phe Phe Asn 
                85                  90                  95      


Arg Thr Cys His Cys Asn Gly Asn Phe Ser Gly His Asn Cys Gly Thr 
            100                 105                 110         


Cys Arg Pro Gly Trp Arg Gly Ala Ala Cys Asp Gln Arg Val Leu Ile 
        115                 120                 125             


Val Arg Arg Asn Leu Leu Asp Leu Ser Lys Glu Glu Lys Asn His Phe 
    130                 135                 140                 


Val Arg Ala Leu Asp Met Ala Lys Arg Thr Thr His Pro Leu Phe Val 
145                 150                 155                 160 


Ile Ala Thr Arg Arg Ser Glu Glu Ile Leu Gly Pro Asp Gly Asn Thr 
                165                 170                 175     


Pro Gln Phe Glu Asn Ile Ser Ile Tyr Asn Tyr Phe Val Trp Thr His 
            180                 185                 190         


Tyr Tyr Ser Val Lys Lys Thr Phe Leu Gly Val Gly Gln Glu Ser Phe 
        195                 200                 205             


Gly Glu Val Asp Phe Ser His Glu Gly Pro Ala Phe Leu Thr Trp His 
    210                 215                 220                 


Arg Tyr His Leu Leu Arg Leu Glu Lys Asp Met Gln Glu Met Leu Gln 
225                 230                 235                 240 


Glu Pro Ser Phe Ser Leu Pro Tyr Trp Asn Phe Ala Thr Gly Lys Asn 
                245                 250                 255     


Val Cys Asp Ile Cys Thr Asp Asp Leu Met Gly Ser Arg Ser Asn Phe 
            260                 265                 270         


Asp Ser Thr Leu Ile Ser Pro Asn Ser Val Phe Ser Gln Trp Arg Val 
        275                 280                 285             


Val Cys Asp Ser Leu Glu Asp Tyr Asp Thr Leu Gly Thr Leu Cys Asn 
    290                 295                 300                 


Ser Thr Glu Asp Gly Pro Ile Arg Arg Asn Pro Ala Gly Asn Val Ala 
305                 310                 315                 320 


Arg Pro Met Val Gln Arg Leu Pro Glu Pro Gln Asp Val Ala Gln Cys 
                325                 330                 335     


Leu Glu Val Gly Leu Phe Asp Thr Pro Pro Phe Tyr Ser Asn Ser Thr 
            340                 345                 350         


Asn Ser Phe Arg Asn Thr Val Glu Gly Tyr Ser Asp Pro Thr Gly Lys 
        355                 360                 365             


Tyr Asp Pro Ala Val Arg Ser Leu His Asn Leu Ala His Leu Phe Leu 
    370                 375                 380                 


Asn Gly Thr Gly Gly Gln Thr His Leu Ser Pro Asn Asp Pro Ile Phe 
385                 390                 395                 400 


Val Leu Leu His Thr Phe Thr Asp Ala Val Phe Asp Glu Trp Leu Arg 
                405                 410                 415     


Arg Tyr Asn Ala Asp Ile Ser Thr Phe Pro Leu Glu Asn Ala Pro Ile 
            420                 425                 430         


Gly His Asn Arg Gln Tyr Asn Met Val Pro Phe Trp Pro Pro Val Thr 
        435                 440                 445             


Asn Thr Glu Met Phe Val Thr Ala Pro Asp Asn Leu Gly Tyr Thr Tyr 
    450                 455                 460                 


Glu Ile Gln Trp Pro Ser Arg Glu Phe Ser Val Pro Glu Ile Ile Ala 
465                 470                 475                 480 


Ile Ala Val Val Gly Ala Leu Leu Leu Val Ala Leu Ile Phe Gly Thr 
                485                 490                 495     


Ala Ser Tyr Leu Ile Arg Ala Arg Arg Ser Met Asp Glu Ala Asn Gln 
            500                 505                 510         


Pro Leu Leu Thr Asp Gln Tyr Gln Cys Tyr Ala Glu Glu Tyr Glu Lys 
        515                 520                 525             


Leu Gln Asn Pro Asn Gln Ser Val Val 
    530                 535         


<210>  161
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  161

Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
            20                  25                  30          


Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro 
        35                  40                  45              


Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met 
    50                  55                  60                  


Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
65                  70                  75                  80  


Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu 
                85                  90                  95      


Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu 
            100                 105                 110         


Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp 
        115                 120                 125             


Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys 
    130                 135                 140                 


Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser 
145                 150                 155                 160 


Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu 
                165                 170                 175     


Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val 
            180                 185                 190         


Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys 
        195                 200                 205             


Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu 
    210                 215                 


<210>  162
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  162

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Asn Asp Glu His 
                325                 330                 335     


Lys Pro Leu Arg Glu Trp Phe Val Ile Val Ile Met Ala Thr Ile Cys 
            340                 345                 350         


Phe Ile Leu Leu Ile Leu Ser Leu Ile Cys Lys Ile Cys His Leu Trp 
        355                 360                 365             


Ile Lys Leu Phe Pro Pro Ile Pro Ala Pro Lys Ser Asn Ile Lys Asp 
    370                 375                 380                 


Leu Phe Val Thr Thr Asn Tyr Glu Lys Ala Gly Ser Ser Glu Thr Glu 
385                 390                 395                 400 


Ile Glu Val Ile Cys Tyr Ile Glu Lys Pro Gly Val Glu Thr Leu Glu 
                405                 410                 415     


Asp Ser Val Phe 
            420 


<210>  163
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  163

Met Leu Ala Val Gly Cys Ala Leu Leu Ala Ala Leu Leu Ala Ala Pro 
1               5                   10                  15      


Gly Ala Ala Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg 
            20                  25                  30          


Gly Val Leu Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro 
        35                  40                  45              


Gly Val Glu Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys 
    50                  55                  60                  


Pro Ala Ala Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg 
65                  70                  75                  80  


Leu Leu Leu Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys 
                85                  90                  95      


Tyr Arg Ala Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val 
            100                 105                 110         


Pro Pro Glu Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser 
        115                 120                 125             


Asn Val Val Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr 
    130                 135                 140                 


Lys Ala Val Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp 
145                 150                 155                 160 


Phe Gln Glu Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys 
                165                 170                 175     


Gln Leu Ala Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met 
            180                 185                 190         


Cys Val Ala Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe 
        195                 200                 205             


Gln Gly Cys Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val 
    210                 215                 220                 


Thr Ala Val Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp 
225                 230                 235                 240 


Pro His Ser Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg 
                245                 250                 255     


Tyr Arg Ala Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp 
            260                 265                 270         


Leu Gln His His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His 
        275                 280                 285             


Val Val Gln Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser 
    290                 295                 300                 


Glu Trp Ser Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser 
305                 310                 315                 320 


Pro Pro Ala Glu Asn Glu Val Ser Thr Pro Met Gln Ala Leu Thr Thr 
                325                 330                 335     


Asn Lys Asp Asp Asp Asn Ile Leu Phe Arg Asp Ser Ala Asn Ala Thr 
            340                 345                 350         


Ser Leu Pro Val Gln Asp Ser Ser Ser Val Pro Leu Pro Thr Phe Leu 
        355                 360                 365             


Val Ala Gly Gly Ser Leu Ala Phe Gly Thr Leu Leu Cys Ile Ala Ile 
    370                 375                 380                 


Val Leu Arg Phe Lys Lys Thr Trp Lys Leu Arg Ala Leu Lys Glu Gly 
385                 390                 395                 400 


Lys Thr Ser Met His Pro Pro Tyr Ser Leu Gly Gln Leu Val Pro Glu 
                405                 410                 415     


Arg Pro Arg Pro Thr Pro Val Leu Val Pro Leu Ile Ser Pro Pro Val 
            420                 425                 430         


Ser Pro Ser Ser Leu Gly Ser Asp Asn Thr Ser Ser His Asn Arg Pro 
        435                 440                 445             


Asp Ala Arg Asp Pro Arg Ser Pro Tyr Asp Ile Ser Asn Thr Asp Tyr 
    450                 455                 460                 


Phe Phe Pro Arg 
465             


<210>  164
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  164

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Ser Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Asn Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asn Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Asp Arg Lys Tyr Phe His His Asn Ser Asp Phe His Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Ser Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile 
225                 230             


<210>  165
<211>  2039
<212>  PRT
<213>  Homo sapiens

<400>  165

Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
1               5                   10                  15      


Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
            20                  25                  30          


Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
        35                  40                  45              


Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro 
    50                  55                  60                  


Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
65                  70                  75                  80  


Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys 
                85                  90                  95      


Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
            100                 105                 110         


Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
        115                 120                 125             


Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr 
    130                 135                 140                 


Cys Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile 
145                 150                 155                 160 


Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp 
                165                 170                 175     


Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr 
            180                 185                 190         


Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
        195                 200                 205             


Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile 
    210                 215                 220                 


Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro 
225                 230                 235                 240 


Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
                245                 250                 255     


Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met 
            260                 265                 270         


Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
        275                 280                 285             


Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
    290                 295                 300                 


His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
305                 310                 315                 320 


Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala 
                325                 330                 335     


Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr 
            340                 345                 350         


Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly 
        355                 360                 365             


Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
    370                 375                 380                 


Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
385                 390                 395                 400 


Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
                405                 410                 415     


Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His 
            420                 425                 430         


Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Thr Val Asn Tyr 
        435                 440                 445             


Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly 
    450                 455                 460                 


Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp 
465                 470                 475                 480 


Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro 
                485                 490                 495     


Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp 
            500                 505                 510         


Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
        515                 520                 525             


Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser 
    530                 535                 540                 


Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro 
545                 550                 555                 560 


Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg 
                565                 570                 575     


Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser 
            580                 585                 590         


Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro 
        595                 600                 605             


Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn 
    610                 615                 620                 


Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val 
625                 630                 635                 640 


Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu 
                645                 650                 655     


Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val 
            660                 665                 670         


Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys 
        675                 680                 685             


Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser 
    690                 695                 700                 


Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe 
705                 710                 715                 720 


Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp 
                725                 730                 735     


Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp 
            740                 745                 750         


Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro 
        755                 760                 765             


Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly 
    770                 775                 780                 


Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala 
785                 790                 795                 800 


Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu 
                805                 810                 815     


Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val 
            820                 825                 830         


Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser 
        835                 840                 845             


Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro 
    850                 855                 860                 


Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly 
865                 870                 875                 880 


Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val 
                885                 890                 895     


Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu 
            900                 905                 910         


Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly 
        915                 920                 925             


Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln 
    930                 935                 940                 


Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala 
945                 950                 955                 960 


Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu 
                965                 970                 975     


Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp 
            980                 985                 990         


Ser Ser Pro Lys Asp Val Cys Lys  Arg Lys Ser Cys Lys  Thr Pro Pro 
        995                 1000                 1005             


Asp Pro  Val Asn Gly Met Val  His Val Ile Thr Asp  Ile Gln Val 
    1010                 1015                 1020             


Gly Ser  Arg Ile Asn Tyr Ser  Cys Thr Thr Gly His  Arg Leu Ile 
    1025                 1030                 1035             


Gly His  Ser Ser Ala Glu Cys  Ile Leu Ser Gly Asn  Thr Ala His 
    1040                 1045                 1050             


Trp Ser  Thr Lys Pro Pro Ile  Cys Gln Arg Ile Pro  Cys Gly Leu 
    1055                 1060                 1065             


Pro Pro  Thr Ile Ala Asn Gly  Asp Phe Ile Ser Thr  Asn Arg Glu 
    1070                 1075                 1080             


Asn Phe  His Tyr Gly Ser Val  Val Thr Tyr Arg Cys  Asn Leu Gly 
    1085                 1090                 1095             


Ser Arg  Gly Arg Lys Val Phe  Glu Leu Val Gly Glu  Pro Ser Ile 
    1100                 1105                 1110             


Tyr Cys  Thr Ser Asn Asp Asp  Gln Val Gly Ile Trp  Ser Gly Pro 
    1115                 1120                 1125             


Ala Pro  Gln Cys Ile Ile Pro  Asn Lys Cys Thr Pro  Pro Asn Val 
    1130                 1135                 1140             


Glu Asn  Gly Ile Leu Val Ser  Asp Asn Arg Ser Leu  Phe Ser Leu 
    1145                 1150                 1155             


Asn Glu  Val Val Glu Phe Arg  Cys Gln Pro Gly Phe  Val Met Lys 
    1160                 1165                 1170             


Gly Pro  Arg Arg Val Lys Cys  Gln Ala Leu Asn Lys  Trp Glu Pro 
    1175                 1180                 1185             


Glu Leu  Pro Ser Cys Ser Arg  Val Cys Gln Pro Pro  Pro Glu Ile 
    1190                 1195                 1200             


Leu His  Gly Glu His Thr Pro  Ser His Gln Asp Asn  Phe Ser Pro 
    1205                 1210                 1215             


Gly Gln  Glu Val Phe Tyr Ser  Cys Glu Pro Gly Tyr  Asp Leu Arg 
    1220                 1225                 1230             


Gly Ala  Ala Ser Leu His Cys  Thr Pro Gln Gly Asp  Trp Ser Pro 
    1235                 1240                 1245             


Glu Ala  Pro Arg Cys Ala Val  Lys Ser Cys Asp Asp  Phe Leu Gly 
    1250                 1255                 1260             


Gln Leu  Pro His Gly Arg Val  Leu Phe Pro Leu Asn  Leu Gln Leu 
    1265                 1270                 1275             


Gly Ala  Lys Val Ser Phe Val  Cys Asp Glu Gly Phe  Arg Leu Lys 
    1280                 1285                 1290             


Gly Ser  Ser Val Ser His Cys  Val Leu Val Gly Met  Arg Ser Leu 
    1295                 1300                 1305             


Trp Asn  Asn Ser Val Pro Val  Cys Glu His Ile Phe  Cys Pro Asn 
    1310                 1315                 1320             


Pro Pro  Ala Ile Leu Asn Gly  Arg His Thr Gly Thr  Pro Ser Gly 
    1325                 1330                 1335             


Asp Ile  Pro Tyr Gly Lys Glu  Ile Ser Tyr Thr Cys  Asp Pro His 
    1340                 1345                 1350             


Pro Asp  Arg Gly Met Thr Phe  Asn Leu Ile Gly Glu  Ser Thr Ile 
    1355                 1360                 1365             


Arg Cys  Thr Ser Asp Pro His  Gly Asn Gly Val Trp  Ser Ser Pro 
    1370                 1375                 1380             


Ala Pro  Arg Cys Glu Leu Ser  Val Arg Ala Gly His  Cys Lys Thr 
    1385                 1390                 1395             


Pro Glu  Gln Phe Pro Phe Ala  Ser Pro Thr Ile Pro  Ile Asn Asp 
    1400                 1405                 1410             


Phe Glu  Phe Pro Val Gly Thr  Ser Leu Asn Tyr Glu  Cys Arg Pro 
    1415                 1420                 1425             


Gly Tyr  Phe Gly Lys Met Phe  Ser Ile Ser Cys Leu  Glu Asn Leu 
    1430                 1435                 1440             


Val Trp  Ser Ser Val Glu Asp  Asn Cys Arg Arg Lys  Ser Cys Gly 
    1445                 1450                 1455             


Pro Pro  Pro Glu Pro Phe Asn  Gly Met Val His Ile  Asn Thr Asp 
    1460                 1465                 1470             


Thr Gln  Phe Gly Ser Thr Val  Asn Tyr Ser Cys Asn  Glu Gly Phe 
    1475                 1480                 1485             


Arg Leu  Ile Gly Ser Pro Ser  Thr Thr Cys Leu Val  Ser Gly Asn 
    1490                 1495                 1500             


Asn Val  Thr Trp Asp Lys Lys  Ala Pro Ile Cys Glu  Ile Ile Ser 
    1505                 1510                 1515             


Cys Glu  Pro Pro Pro Thr Ile  Ser Asn Gly Asp Phe  Tyr Ser Asn 
    1520                 1525                 1530             


Asn Arg  Thr Ser Phe His Asn  Gly Thr Val Val Thr  Tyr Gln Cys 
    1535                 1540                 1545             


His Thr  Gly Pro Asp Gly Glu  Gln Leu Phe Glu Leu  Val Gly Glu 
    1550                 1555                 1560             


Arg Ser  Ile Tyr Cys Thr Ser  Lys Asp Asp Gln Val  Gly Val Trp 
    1565                 1570                 1575             


Ser Ser  Pro Pro Pro Arg Cys  Ile Ser Thr Asn Lys  Cys Thr Ala 
    1580                 1585                 1590             


Pro Glu  Val Glu Asn Ala Ile  Arg Val Pro Gly Asn  Arg Ser Phe 
    1595                 1600                 1605             


Phe Thr  Leu Thr Glu Ile Ile  Arg Phe Arg Cys Gln  Pro Gly Phe 
    1610                 1615                 1620             


Val Met  Val Gly Ser His Thr  Val Gln Cys Gln Thr  Asn Gly Arg 
    1625                 1630                 1635             


Trp Gly  Pro Lys Leu Pro His  Cys Ser Arg Val Cys  Gln Pro Pro 
    1640                 1645                 1650             


Pro Glu  Ile Leu His Gly Glu  His Thr Leu Ser His  Gln Asp Asn 
    1655                 1660                 1665             


Phe Ser  Pro Gly Gln Glu Val  Phe Tyr Ser Cys Glu  Pro Ser Tyr 
    1670                 1675                 1680             


Asp Leu  Arg Gly Ala Ala Ser  Leu His Cys Thr Pro  Gln Gly Asp 
    1685                 1690                 1695             


Trp Ser  Pro Glu Ala Pro Arg  Cys Thr Val Lys Ser  Cys Asp Asp 
    1700                 1705                 1710             


Phe Leu  Gly Gln Leu Pro His  Gly Arg Val Leu Leu  Pro Leu Asn 
    1715                 1720                 1725             


Leu Gln  Leu Gly Ala Lys Val  Ser Phe Val Cys Asp  Glu Gly Phe 
    1730                 1735                 1740             


Arg Leu  Lys Gly Arg Ser Ala  Ser His Cys Val Leu  Ala Gly Met 
    1745                 1750                 1755             


Lys Ala  Leu Trp Asn Ser Ser  Val Pro Val Cys Glu  Gln Ile Phe 
    1760                 1765                 1770             


Cys Pro  Asn Pro Pro Ala Ile  Leu Asn Gly Arg His  Thr Gly Thr 
    1775                 1780                 1785             


Pro Phe  Gly Asp Ile Pro Tyr  Gly Lys Glu Ile Ser  Tyr Ala Cys 
    1790                 1795                 1800             


Asp Thr  His Pro Asp Arg Gly  Met Thr Phe Asn Leu  Ile Gly Glu 
    1805                 1810                 1815             


Ser Ser  Ile Arg Cys Thr Ser  Asp Pro Gln Gly Asn  Gly Val Trp 
    1820                 1825                 1830             


Ser Ser  Pro Ala Pro Arg Cys  Glu Leu Ser Val Pro  Ala Ala Cys 
    1835                 1840                 1845             


Pro His  Pro Pro Lys Ile Gln  Asn Gly His Tyr Ile  Gly Gly His 
    1850                 1855                 1860             


Val Ser  Leu Tyr Leu Pro Gly  Met Thr Ile Ser Tyr  Ile Cys Asp 
    1865                 1870                 1875             


Pro Gly  Tyr Leu Leu Val Gly  Lys Gly Phe Ile Phe  Cys Thr Asp 
    1880                 1885                 1890             


Gln Gly  Ile Trp Ser Gln Leu  Asp His Tyr Cys Lys  Glu Val Asn 
    1895                 1900                 1905             


Cys Ser  Phe Pro Leu Phe Met  Asn Gly Ile Ser Lys  Glu Leu Glu 
    1910                 1915                 1920             


Met Lys  Lys Val Tyr His Tyr  Gly Asp Tyr Val Thr  Leu Lys Cys 
    1925                 1930                 1935             


Glu Asp  Gly Tyr Thr Leu Glu  Gly Ser Pro Trp Ser  Gln Cys Gln 
    1940                 1945                 1950             


Ala Asp  Asp Arg Trp Asp Pro  Pro Leu Ala Lys Cys  Thr Ser Arg 
    1955                 1960                 1965             


Thr His  Asp Ala Leu Ile Val  Gly Thr Leu Ser Gly  Thr Ile Phe 
    1970                 1975                 1980             


Phe Ile  Leu Leu Ile Ile Phe  Leu Ser Trp Ile Ile  Leu Lys His 
    1985                 1990                 1995             


Arg Lys  Gly Asn Asn Ala His  Glu Asn Pro Lys Glu  Val Ala Ile 
    2000                 2005                 2010             


His Leu  His Ser Gln Gly Gly  Ser Ser Val His Pro  Arg Thr Leu 
    2015                 2020                 2025             


Gln Thr  Asn Glu Glu Asn Ser  Arg Val Leu Pro 
    2030                 2035                 


<210>  166
<211>  550
<212>  PRT
<213>  Homo sapiens

<400>  166

Met Thr Gly Asp Lys Gly Pro Gln Arg Leu Ser Gly Ser Ser Tyr Gly 
1               5                   10                  15      


Ser Ile Ser Ser Pro Thr Ser Pro Thr Ser Pro Gly Pro Gln Gln Ala 
            20                  25                  30          


Pro Pro Arg Glu Thr Tyr Leu Ser Glu Lys Ile Pro Ile Pro Asp Thr 
        35                  40                  45              


Lys Pro Gly Thr Phe Ser Leu Arg Lys Leu Trp Ala Phe Thr Gly Pro 
    50                  55                  60                  


Gly Phe Leu Met Ser Ile Ala Phe Leu Asp Pro Gly Asn Ile Glu Ser 
65                  70                  75                  80  


Asp Leu Gln Ala Gly Ala Val Ala Gly Phe Lys Leu Leu Trp Val Leu 
                85                  90                  95      


Leu Trp Ala Thr Val Leu Gly Leu Leu Cys Gln Arg Leu Ala Ala Arg 
            100                 105                 110         


Leu Gly Val Val Thr Gly Lys Asp Leu Gly Glu Val Cys His Leu Tyr 
        115                 120                 125             


Tyr Pro Lys Val Pro Arg Thr Val Leu Trp Leu Thr Ile Glu Leu Ala 
    130                 135                 140                 


Ile Val Gly Ser Asp Met Gln Glu Val Ile Gly Thr Ala Ile Ala Phe 
145                 150                 155                 160 


Asn Leu Leu Ser Ala Gly Arg Ile Pro Leu Trp Gly Gly Val Leu Ile 
                165                 170                 175     


Thr Ile Val Asp Thr Phe Phe Phe Leu Phe Leu Asp Asn Tyr Gly Leu 
            180                 185                 190         


Arg Lys Leu Glu Ala Phe Phe Gly Leu Leu Ile Thr Ile Met Ala Leu 
        195                 200                 205             


Thr Phe Gly Tyr Glu Tyr Val Val Ala Arg Pro Glu Gln Gly Ala Leu 
    210                 215                 220                 


Leu Arg Gly Leu Phe Leu Pro Ser Cys Pro Gly Cys Gly His Pro Glu 
225                 230                 235                 240 


Leu Leu Gln Ala Val Gly Ile Val Gly Ala Ile Ile Met Pro His Asn 
                245                 250                 255     


Ile Tyr Leu His Ser Ala Leu Val Lys Ser Arg Glu Ile Asp Arg Ala 
            260                 265                 270         


Arg Arg Ala Asp Ile Arg Glu Ala Asn Met Tyr Phe Leu Ile Glu Ala 
        275                 280                 285             


Thr Ile Ala Leu Ser Val Ser Phe Ile Ile Asn Leu Phe Val Met Ala 
    290                 295                 300                 


Val Phe Gly Gln Ala Phe Tyr Gln Lys Thr Asn Gln Ala Ala Phe Asn 
305                 310                 315                 320 


Ile Cys Ala Asn Ser Ser Leu His Asp Tyr Ala Lys Ile Phe Pro Met 
                325                 330                 335     


Asn Asn Ala Thr Val Ala Val Asp Ile Tyr Gln Gly Gly Val Ile Leu 
            340                 345                 350         


Gly Cys Leu Phe Gly Pro Ala Ala Leu Tyr Ile Trp Ala Ile Gly Leu 
        355                 360                 365             


Leu Ala Ala Gly Gln Ser Ser Thr Met Thr Gly Thr Tyr Ala Gly Gln 
    370                 375                 380                 


Phe Val Met Glu Gly Phe Leu Arg Leu Arg Trp Ser Arg Phe Ala Arg 
385                 390                 395                 400 


Val Leu Leu Thr Arg Ser Cys Ala Ile Leu Pro Thr Val Leu Val Ala 
                405                 410                 415     


Val Phe Arg Asp Leu Arg Asp Leu Ser Gly Leu Asn Asp Leu Leu Asn 
            420                 425                 430         


Val Leu Gln Ser Leu Leu Leu Pro Phe Ala Val Leu Pro Ile Leu Thr 
        435                 440                 445             


Phe Thr Ser Met Pro Thr Leu Met Gln Glu Phe Ala Asn Gly Leu Leu 
    450                 455                 460                 


Asn Lys Val Val Thr Ser Ser Ile Met Val Leu Val Cys Ala Ile Asn 
465                 470                 475                 480 


Leu Tyr Phe Val Val Ser Tyr Leu Pro Ser Leu Pro His Pro Ala Tyr 
                485                 490                 495     


Phe Gly Leu Ala Ala Leu Leu Ala Ala Ala Tyr Leu Gly Leu Ser Thr 
            500                 505                 510         


Tyr Leu Val Trp Thr Cys Cys Leu Ala His Gly Ala Thr Phe Leu Ala 
        515                 520                 525             


His Ser Ser His His His Phe Leu Tyr Gly Leu Leu Glu Glu Asp Gln 
    530                 535                 540                 


Lys Gly Glu Thr Ser Gly 
545                 550 


<210>  167
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  167

Met Asp Tyr Gln Val Ser Ser Pro Ile Tyr Asp Ile Asn Tyr Tyr Thr 
1               5                   10                  15      


Ser Glu Pro Cys Gln Lys Ile Asn Val Lys Gln Ile Ala Ala Arg Leu 
            20                  25                  30          


Leu Pro Pro Leu Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn 
        35                  40                  45              


Met Leu Val Ile Leu Ile Leu Ile Asn Cys Lys Arg Leu Lys Ser Met 
    50                  55                  60                  


Thr Asp Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp Leu Phe Phe Leu 
65                  70                  75                  80  


Leu Thr Val Pro Phe Trp Ala His Tyr Ala Ala Ala Gln Trp Asp Phe 
                85                  90                  95      


Gly Asn Thr Met Cys Gln Leu Leu Thr Gly Leu Tyr Phe Ile Gly Phe 
            100                 105                 110         


Phe Ser Gly Ile Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu 
        115                 120                 125             


Ala Val Val His Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe 
    130                 135                 140                 


Gly Val Val Thr Ser Val Ile Thr Trp Val Val Ala Val Phe Ala Ser 
145                 150                 155                 160 


Leu Pro Gly Ile Ile Phe Thr Arg Ser Gln Lys Glu Gly Leu His Tyr 
                165                 170                 175     


Thr Cys Ser Ser His Phe Pro Tyr Ser Gln Tyr Gln Phe Trp Lys Asn 
            180                 185                 190         


Phe Gln Thr Leu Lys Ile Val Ile Leu Gly Leu Val Leu Pro Leu Leu 
        195                 200                 205             


Val Met Val Ile Cys Tyr Ser Gly Ile Leu Lys Thr Leu Leu Arg Cys 
    210                 215                 220                 


Arg Asn Glu Lys Lys Arg His Arg Ala Val Arg Leu Ile Phe Thr Ile 
225                 230                 235                 240 


Met Ile Val Tyr Phe Leu Phe Trp Ala Pro Tyr Asn Ile Val Leu Leu 
                245                 250                 255     


Leu Asn Thr Phe Gln Glu Phe Phe Gly Leu Asn Asn Cys Ser Ser Ser 
            260                 265                 270         


Asn Arg Leu Asp Gln Ala Met Gln Val Thr Glu Thr Leu Gly Met Thr 
        275                 280                 285             


His Cys Cys Ile Asn Pro Ile Ile Tyr Ala Phe Val Gly Glu Lys Phe 
    290                 295                 300                 


Arg Asn Tyr Leu Leu Val Phe Phe Gln Lys His Ile Ala Lys Arg Phe 
305                 310                 315                 320 


Cys Lys Cys Cys Ser Ile Phe Gln Gln Glu Ala Pro Glu Arg Ala Ser 
                325                 330                 335     


Ser Val Tyr Thr Arg Ser Thr Gly Glu Gln Glu Ile Ser Val Gly Leu 
            340                 345                 350         


<210>  168
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  168

Met Thr Ser Lys Leu Ala Val Ala Leu Leu Ala Ala Phe Leu Ile Ser 
1               5                   10                  15      


Ala Ala Leu Cys Glu Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu 
            20                  25                  30          


Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe 
        35                  40                  45              


Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr 
    50                  55                  60                  


Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro 
65                  70                  75                  80  


Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg Ala 
                85                  90                  95      


Glu Asn Ser 
            


<210>  169
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  169

Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
    50                  55                  60                  


Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser 
65                  70                  75                  80  


Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
                85                  90                  95      


Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
            100                 105                 110         


Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
        115                 120                 125             


Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
    130                 135                 140                 


Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
145                 150                 155                 160 


Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
                165                 170                 175     


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
            180                 185                 190         


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
        195                 200                 205             


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 
    210                 215                 220                 


Gln Val Tyr Phe Gly Ile Ile Ala Leu 
225                 230             


<210>  170
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  170

Met Thr Pro Pro Glu Arg Leu Phe Leu Pro Arg Val Cys Gly Thr Thr 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Gly Leu Leu Leu Val Leu Leu Pro Gly Ala 
            20                  25                  30          


Gln Gly Leu Pro Gly Val Gly Leu Thr Pro Ser Ala Ala Gln Thr Ala 
        35                  40                  45              


Arg Gln His Pro Lys Met His Leu Ala His Ser Thr Leu Lys Pro Ala 
    50                  55                  60                  


Ala His Leu Ile Gly Asp Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg 
65                  70                  75                  80  


Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp Gly Phe Ser Leu Ser Asn 
                85                  90                  95      


Asn Ser Leu Leu Val Pro Thr Ser Gly Ile Tyr Phe Val Tyr Ser Gln 
            100                 105                 110         


Val Val Phe Ser Gly Lys Ala Tyr Ser Pro Lys Ala Thr Ser Ser Pro 
        115                 120                 125             


Leu Tyr Leu Ala His Glu Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe 
    130                 135                 140                 


His Val Pro Leu Leu Ser Ser Gln Lys Met Val Tyr Pro Gly Leu Gln 
145                 150                 155                 160 


Glu Pro Trp Leu His Ser Met Tyr His Gly Ala Ala Phe Gln Leu Thr 
                165                 170                 175     


Gln Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Pro His Leu Val 
            180                 185                 190         


Leu Ser Pro Ser Thr Val Phe Phe Gly Ala Phe Ala Leu 
        195                 200                 205 


<210>  171
<211>  728
<212>  PRT
<213>  Homo sapiens

<400>  171

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr 
                165                 170                 175     


Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser 
            180                 185                 190         


Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu 
        195                 200                 205             


Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp 
    210                 215                 220                 


His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro 
225                 230                 235                 240 


His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp 
                245                 250                 255     


Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr 
            260                 265                 270         


Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys 
        275                 280                 285             


Ala Asp Asn Thr Met Asn Asp Thr Asp Val Pro Leu Glu Thr Thr Glu 
    290                 295                 300                 


Cys Ile Gln Gly Gln Gly Glu Gly Tyr Arg Gly Thr Val Asn Thr Ile 
305                 310                 315                 320 


Trp Asn Gly Ile Pro Cys Gln Arg Trp Asp Ser Gln Tyr Pro His Glu 
                325                 330                 335     


His Asp Met Thr Pro Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu Asn 
            340                 345                 350         


Tyr Cys Arg Asn Pro Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr Thr 
        355                 360                 365             


Asp Pro Asn Ile Arg Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys Asp 
    370                 375                 380                 


Met Ser His Gly Gln Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr Met 
385                 390                 395                 400 


Gly Asn Leu Ser Gln Thr Arg Ser Gly Leu Thr Cys Ser Met Trp Asp 
                405                 410                 415     


Lys Asn Met Glu Asp Leu His Arg His Ile Phe Trp Glu Pro Asp Ala 
            420                 425                 430         


Ser Lys Leu Asn Glu Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala His 
        435                 440                 445             


Gly Pro Trp Cys Tyr Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr Cys 
    450                 455                 460                 


Pro Ile Ser Arg Cys Glu Gly Asp Thr Thr Pro Thr Ile Val Asn Leu 
465                 470                 475                 480 


Asp His Pro Val Ile Ser Cys Ala Lys Thr Lys Gln Leu Arg Val Val 
                485                 490                 495     


Asn Gly Ile Pro Thr Arg Thr Asn Ile Gly Trp Met Val Ser Leu Arg 
            500                 505                 510         


Tyr Arg Asn Lys His Ile Cys Gly Gly Ser Leu Ile Lys Glu Ser Trp 
        515                 520                 525             


Val Leu Thr Ala Arg Gln Cys Phe Pro Ser Arg Asp Leu Lys Asp Tyr 
    530                 535                 540                 


Glu Ala Trp Leu Gly Ile His Asp Val His Gly Arg Gly Asp Glu Lys 
545                 550                 555                 560 


Cys Lys Gln Val Leu Asn Val Ser Gln Leu Val Tyr Gly Pro Glu Gly 
                565                 570                 575     


Ser Asp Leu Val Leu Met Lys Leu Ala Arg Pro Ala Val Leu Asp Asp 
            580                 585                 590         


Phe Val Ser Thr Ile Asp Leu Pro Asn Tyr Gly Cys Thr Ile Pro Glu 
        595                 600                 605             


Lys Thr Ser Cys Ser Val Tyr Gly Trp Gly Tyr Thr Gly Leu Ile Asn 
    610                 615                 620                 


Tyr Asp Gly Leu Leu Arg Val Ala His Leu Tyr Ile Met Gly Asn Glu 
625                 630                 635                 640 


Lys Cys Ser Gln His His Arg Gly Lys Val Thr Leu Asn Glu Ser Glu 
                645                 650                 655     


Ile Cys Ala Gly Ala Glu Lys Ile Gly Ser Gly Pro Cys Glu Gly Asp 
            660                 665                 670         


Tyr Gly Gly Pro Leu Val Cys Glu Gln His Lys Met Arg Met Val Leu 
        675                 680                 685             


Gly Val Ile Val Pro Gly Arg Gly Cys Ala Ile Pro Asn Arg Pro Gly 
    690                 695                 700                 


Ile Phe Val Arg Val Ala Tyr Tyr Ala Lys Trp Ile His Lys Ile Ile 
705                 710                 715                 720 


Leu Thr Tyr Lys Val Pro Gln Ser 
                725             


<210>  172
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  172

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 
    210                 215                 220                 


Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 
225                 230                 235                 240 


Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     


His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile 
            260                 265                 270         


Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg 
        275                 280                 285             


His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile 
    290                 295                 300                 


Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln 
305                 310                 315                 320 


Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val 
                325                 330                 335     


Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr 
            340                 345                 350         


Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile 
        355                 360                 365             


His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr 
    370                 375                 380                 


Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys 
385                 390                 395                 400 


Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro 
                405                 410                 415     


Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His 
            420                 425                 430         


Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser 
        435                 440                 445             


Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly 
    450                 455                 460                 


His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr 
465                 470                 475                 480 


Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp 
                485                 490                 495     


Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser 
            500                 505                 510         


Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr 
        515                 520                 525             


Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg 
    530                 535                 540                 


Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr 
545                 550                 555                 560 


Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val 
                565                 570                 575     


Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly 
            580                 585                 590         


Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr 
        595                 600                 605             


Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp 
    610                 615                 620                 


Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly 
625                 630                 635                 640 


Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser 
                645                 650                 655     


Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser 
            660                 665                 670         


Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn 
        675                 680                 685             


Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser 
    690                 695                 700                 


Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr 
705                 710                 715                 720 


Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val 
                725                 730                 735     


Asp Met Lys Ile Gly Val 
            740         


<210>  173
<211>  848
<212>  PRT
<213>  Homo sapiens

<400>  173

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Thr Leu Asp Gly His Met Val Val Arg Ser His Ala Arg Val Ser 
        355                 360                 365             


Ser Leu Thr Leu Lys Ser Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile 
    370                 375                 380                 


Cys Thr Ala Ser Asn Thr Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu 
385                 390                 395                 400 


Glu Val Gln Tyr Ala Pro Lys Leu Gln Gly Pro Val Ala Val Tyr Thr 
                405                 410                 415     


Trp Glu Gly Asn Gln Val Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro 
            420                 425                 430         


Ser Ala Thr Ile Ser Trp Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser 
        435                 440                 445             


Asn Tyr Ser Asn Ile Lys Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu 
    450                 455                 460                 


Glu Val Thr Pro Asp Ser Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr 
465                 470                 475                 480 


Ala Val Asn Arg Ile Gly Gln Glu Ser Leu Glu Phe Ile Leu Val Gln 
                485                 490                 495     


Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser 
            500                 505                 510         


Ser Thr Ala Gln Val Gln Phe Asp Glu Pro Glu Ala Thr Gly Gly Val 
        515                 520                 525             


Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg Ala Val Gly Glu Glu Val 
    530                 535                 540                 


Trp His Ser Lys Trp Tyr Asp Ala Lys Glu Ala Ser Met Glu Gly Ile 
545                 550                 555                 560 


Val Thr Ile Val Gly Leu Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu 
                565                 570                 575     


Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu 
            580                 585                 590         


Phe Lys Thr Gln Pro Val Gln Gly Glu Pro Ser Ala Pro Lys Leu Glu 
        595                 600                 605             


Gly Gln Met Gly Glu Asp Gly Asn Ser Ile Lys Val Asn Leu Ile Lys 
    610                 615                 620                 


Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu Val Arg Tyr Arg 
625                 630                 635                 640 


Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser 
                645                 650                 655     


Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala Glu Tyr Glu Val 
            660                 665                 670         


Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys Ala Ala His Phe 
        675                 680                 685             


Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro Ala Asn Gly Ser 
    690                 695                 700                 


Pro Thr Ser Gly Leu Ser Thr Gly Ala Ile Val Gly Ile Leu Ile Val 
705                 710                 715                 720 


Ile Phe Val Leu Leu Leu Val Val Val Asp Ile Thr Cys Tyr Phe Leu 
                725                 730                 735     


Asn Lys Cys Gly Leu Phe Met Cys Ile Ala Val Asn Leu Cys Gly Lys 
            740                 745                 750         


Ala Gly Pro Gly Ala Lys Gly Lys Asp Met Glu Glu Gly Lys Ala Ala 
        755                 760                 765             


Phe Ser Lys Asp Glu Ser Lys Glu Pro Ile Val Glu Val Arg Thr Glu 
    770                 775                 780                 


Glu Glu Arg Thr Pro Asn His Asp Gly Gly Lys His Thr Glu Pro Asn 
785                 790                 795                 800 


Glu Thr Thr Pro Leu Thr Glu Pro Glu Lys Gly Pro Val Glu Ala Lys 
                805                 810                 815     


Pro Glu Cys Gln Glu Thr Glu Thr Lys Pro Ala Pro Ala Glu Val Lys 
            820                 825                 830         


Thr Val Pro Asn Asp Ala Thr Gln Thr Lys Glu Asn Glu Ser Lys Ala 
        835                 840                 845             


<210>  174
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  174

Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 
1               5                   10                  15      


Ala Leu Leu Pro Ala Ala Thr Gln Gly Lys Lys Val Val Leu Gly Lys 
            20                  25                  30          


Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser 
        35                  40                  45              


Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn 
    50                  55                  60                  


Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala 
65                  70                  75                  80  


Asp Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile 
                85                  90                  95      


Lys Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu 
            100                 105                 110         


Asp Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr Ala Asn 
        115                 120                 125             


Ser Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu 
    130                 135                 140                 


Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg Gly 
145                 150                 155                 160 


Lys Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu Glu Leu 
                165                 170                 175     


Gln Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln Lys Lys 
            180                 185                 190         


Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala Phe Gln Lys Ala Ser 
        195                 200                 205             


Ser Ile Val Tyr Lys Lys Glu Gly Glu Gln Val Glu Phe Ser Phe Pro 
    210                 215                 220                 


Leu Ala Phe Thr Val Glu Lys Leu Thr Gly Ser Gly Glu Leu Trp Trp 
225                 230                 235                 240 


Gln Ala Glu Arg Ala Ser Ser Ser Lys Ser Trp Ile Thr Phe Asp Leu 
                245                 250                 255     


Lys Asn Lys Glu Val Ser Val Lys Arg Val Thr Gln Asp Pro Lys Leu 
            260                 265                 270         


Gln Met Gly Lys Lys Leu Pro Leu His Leu Thr Leu Pro Gln Ala Leu 
        275                 280                 285             


Pro Gln Tyr Ala Gly Ser Gly Asn Leu Thr Leu Ala Leu Glu Ala Lys 
    290                 295                 300                 


Thr Gly Lys Leu His Gln Glu Val Asn Leu Val Val Met Arg Ala Thr 
305                 310                 315                 320 


Gln Leu Gln Lys Asn Leu Thr Cys Glu Val Trp Gly Pro Thr Ser Pro 
                325                 330                 335     


Lys Leu Met Leu Ser Leu Lys Leu Glu Asn Lys Glu Ala Lys Val Ser 
            340                 345                 350         


Lys Arg Glu Lys Ala Val Trp Val Leu Asn Pro Glu Ala Gly Met Trp 
        355                 360                 365             


Gln Cys Leu Leu Ser Asp Ser Gly Gln Val Leu Leu Glu Ser Asn Ile 
    370                 375                 380                 


Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala Leu Ile 
385                 390                 395                 400 


Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile 
                405                 410                 415     


Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met 
            420                 425                 430         


Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro 
        435                 440                 445             


His Arg Phe Gln Lys Thr Cys Ser Pro Ile 
    450                 455             


<210>  175
<211>  561
<212>  PRT
<213>  Homo sapiens

<400>  175

Met Val Leu Gly Pro Glu Gln Lys Met Ser Asp Asp Ser Val Ser Gly 
1               5                   10                  15      


Asp His Gly Glu Ser Ala Ser Leu Gly Asn Ile Asn Pro Ala Tyr Ser 
            20                  25                  30          


Asn Pro Ser Leu Ser Gln Ser Pro Gly Asp Ser Glu Glu Tyr Phe Ala 
        35                  40                  45              


Thr Tyr Phe Asn Glu Lys Ile Ser Ile Pro Glu Glu Glu Tyr Ser Cys 
    50                  55                  60                  


Phe Ser Phe Arg Lys Leu Trp Ala Phe Thr Gly Pro Gly Phe Leu Met 
65                  70                  75                  80  


Ser Ile Ala Tyr Leu Asp Pro Gly Asn Ile Glu Ser Asp Leu Gln Ser 
                85                  90                  95      


Gly Ala Val Ala Gly Phe Lys Leu Leu Trp Ile Leu Leu Leu Ala Thr 
            100                 105                 110         


Leu Val Gly Leu Leu Leu Gln Arg Leu Ala Ala Arg Leu Gly Val Val 
        115                 120                 125             


Thr Gly Leu His Leu Ala Glu Val Cys His Arg Gln Tyr Pro Lys Val 
    130                 135                 140                 


Pro Arg Val Ile Leu Trp Leu Met Val Glu Leu Ala Ile Ile Gly Ser 
145                 150                 155                 160 


Asp Met Gln Glu Val Ile Gly Ser Ala Ile Ala Ile Asn Leu Leu Ser 
                165                 170                 175     


Val Gly Arg Ile Pro Leu Trp Gly Gly Val Leu Ile Thr Ile Ala Asp 
            180                 185                 190         


Thr Phe Val Phe Leu Phe Leu Asp Lys Tyr Gly Leu Arg Lys Leu Glu 
        195                 200                 205             


Ala Phe Phe Gly Phe Leu Ile Thr Ile Met Ala Leu Thr Phe Gly Tyr 
    210                 215                 220                 


Glu Tyr Val Thr Val Lys Pro Ser Gln Ser Gln Val Leu Lys Gly Met 
225                 230                 235                 240 


Phe Val Pro Ser Cys Ser Gly Cys Arg Thr Pro Gln Ile Glu Gln Ala 
                245                 250                 255     


Val Gly Ile Val Gly Ala Val Ile Met Pro His Asn Met Tyr Leu His 
            260                 265                 270         


Ser Ala Leu Val Lys Ser Arg Gln Val Asn Arg Asn Asn Lys Gln Glu 
        275                 280                 285             


Val Arg Glu Ala Asn Lys Tyr Phe Phe Ile Glu Ser Cys Ile Ala Leu 
    290                 295                 300                 


Phe Val Ser Phe Ile Ile Asn Val Phe Val Val Ser Val Phe Ala Glu 
305                 310                 315                 320 


Ala Phe Phe Gly Lys Thr Asn Glu Gln Val Val Glu Val Cys Thr Asn 
                325                 330                 335     


Thr Ser Ser Pro His Ala Gly Leu Phe Pro Lys Asp Asn Ser Thr Leu 
            340                 345                 350         


Ala Val Asp Ile Tyr Lys Gly Gly Val Val Leu Gly Cys Tyr Phe Gly 
        355                 360                 365             


Pro Ala Ala Leu Tyr Ile Trp Ala Val Gly Ile Leu Ala Ala Gly Gln 
    370                 375                 380                 


Ser Ser Thr Met Thr Gly Thr Tyr Ser Gly Gln Phe Val Met Glu Gly 
385                 390                 395                 400 


Phe Leu Asn Leu Lys Trp Ser Arg Phe Ala Arg Val Val Leu Thr Arg 
                405                 410                 415     


Ser Ile Ala Ile Ile Pro Thr Leu Leu Val Ala Val Phe Gln Asp Val 
            420                 425                 430         


Glu His Leu Thr Gly Met Asn Asp Phe Leu Asn Val Leu Gln Ser Leu 
        435                 440                 445             


Gln Leu Pro Phe Ala Leu Ile Pro Ile Leu Thr Phe Thr Ser Leu Arg 
    450                 455                 460                 


Pro Val Met Ser Asp Phe Ala Asn Gly Leu Gly Trp Arg Ile Ala Gly 
465                 470                 475                 480 


Gly Ile Leu Val Leu Ile Ile Cys Ser Ile Asn Met Tyr Phe Val Val 
                485                 490                 495     


Val Tyr Val Arg Asp Leu Gly His Val Ala Leu Tyr Val Val Ala Ala 
            500                 505                 510         


Val Val Ser Val Ala Tyr Leu Gly Phe Val Phe Tyr Leu Gly Trp Gln 
        515                 520                 525             


Cys Leu Ile Ala Leu Gly Met Ser Phe Leu Asp Cys Gly His Thr Val 
    530                 535                 540                 


Ser Ile Ser Lys Gly Leu Leu Thr Glu Glu Ala Thr Arg Gly Tyr Val 
545                 550                 555                 560 


Lys 
    


<210>  176
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  176

Met Asp Ile Leu Cys Glu Glu Asn Thr Ser Leu Ser Ser Thr Thr Asn 
1               5                   10                  15      


Ser Leu Met Gln Leu Asn Asp Asp Thr Arg Leu Tyr Ser Asn Asp Phe 
            20                  25                  30          


Asn Ser Gly Glu Ala Asn Thr Ser Asp Ala Phe Asn Trp Thr Val Asp 
        35                  40                  45              


Ser Glu Asn Arg Thr Asn Leu Ser Cys Glu Gly Cys Leu Ser Pro Ser 
    50                  55                  60                  


Cys Leu Ser Leu Leu His Leu Gln Glu Lys Asn Trp Ser Ala Leu Leu 
65                  70                  75                  80  


Thr Ala Val Val Ile Ile Leu Thr Ile Ala Gly Asn Ile Leu Val Ile 
                85                  90                  95      


Met Ala Val Ser Leu Glu Lys Lys Leu Gln Asn Ala Thr Asn Tyr Phe 
            100                 105                 110         


Leu Met Ser Leu Ala Ile Ala Asp Met Leu Leu Gly Phe Leu Val Met 
        115                 120                 125             


Pro Val Ser Met Leu Thr Ile Leu Tyr Gly Tyr Arg Trp Pro Leu Pro 
    130                 135                 140                 


Ser Lys Leu Cys Ala Val Trp Ile Tyr Leu Asp Val Leu Phe Ser Thr 
145                 150                 155                 160 


Ala Ser Ile Met His Leu Cys Ala Ile Ser Leu Asp Arg Tyr Val Ala 
                165                 170                 175     


Ile Gln Asn Pro Ile His His Ser Arg Phe Asn Ser Arg Thr Lys Ala 
            180                 185                 190         


Phe Leu Lys Ile Ile Ala Val Trp Thr Ile Ser Val Gly Ile Ser Met 
        195                 200                 205             


Pro Ile Pro Val Phe Gly Leu Gln Asp Asp Ser Lys Val Phe Lys Glu 
    210                 215                 220                 


Gly Ser Cys Leu Leu Ala Asp Asp Asn Phe Val Leu Ile Gly Ser Phe 
225                 230                 235                 240 


Val Ser Phe Phe Ile Pro Leu Thr Ile Met Val Ile Thr Tyr Phe Leu 
                245                 250                 255     


Thr Ile Lys Ser Leu Gln Lys Glu Ala Thr Leu Cys Val Ser Asp Leu 
            260                 265                 270         


Gly Thr Arg Ala Lys Leu Ala Ser Phe Ser Phe Leu Pro Gln Ser Ser 
        275                 280                 285             


Leu Ser Ser Glu Lys Leu Phe Gln Arg Ser Ile His Arg Glu Pro Gly 
    290                 295                 300                 


Ser Tyr Thr Gly Arg Arg Thr Met Gln Ser Ile Ser Asn Glu Gln Lys 
305                 310                 315                 320 


Ala Cys Lys Val Leu Gly Ile Val Phe Phe Leu Phe Val Val Met Trp 
                325                 330                 335     


Cys Pro Phe Phe Ile Thr Asn Ile Met Ala Val Ile Cys Lys Glu Ser 
            340                 345                 350         


Cys Asn Glu Asp Val Ile Gly Ala Leu Leu Asn Val Phe Val Trp Ile 
        355                 360                 365             


Gly Tyr Leu Ser Ser Ala Val Asn Pro Leu Val Tyr Thr Leu Phe Asn 
    370                 375                 380                 


Lys Thr Tyr Arg Ser Ala Phe Ser Arg Tyr Ile Gln Cys Gln Tyr Lys 
385                 390                 395                 400 


Glu Asn Lys Lys Pro Leu Gln Leu Ile Leu Val Asn Thr Ile Pro Ala 
                405                 410                 415     


Leu Ala Tyr Lys Ser Ser Gln Leu Gln Met Gly Gln Lys Lys Asn Ser 
            420                 425                 430         


Lys Gln Asp Ala Lys Thr Thr Asp Asn Asp Cys Ser Met Val Ala Leu 
        435                 440                 445             


Gly Lys Gln His Ser Glu Glu Ala Ser Lys Asp Asn Ser Asp Gly Val 
    450                 455                 460                 


Asn Glu Lys Val Ser Cys Val 
465                 470     


<210>  177
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  177

Met Phe Ser Pro Trp Lys Ile Ser Met Phe Leu Ser Val Arg Glu Asp 
1               5                   10                  15      


Ser Val Pro Thr Thr Ala Ser Phe Ser Ala Asp Met Leu Asn Val Thr 
            20                  25                  30          


Leu Gln Gly Pro Thr Leu Asn Gly Thr Phe Ala Gln Ser Lys Cys Pro 
        35                  40                  45              


Gln Val Glu Trp Leu Gly Trp Leu Asn Thr Ile Gln Pro Pro Phe Leu 
    50                  55                  60                  


Trp Val Leu Phe Val Leu Ala Thr Leu Glu Asn Ile Phe Val Leu Ser 
65                  70                  75                  80  


Val Phe Cys Leu His Lys Ser Ser Cys Thr Val Ala Glu Ile Tyr Leu 
                85                  90                  95      


Gly Asn Leu Ala Ala Ala Asp Leu Ile Leu Ala Cys Gly Leu Pro Phe 
            100                 105                 110         


Trp Ala Ile Thr Ile Ser Asn Asn Phe Asp Trp Leu Phe Gly Glu Thr 
        115                 120                 125             


Leu Cys Arg Val Val Asn Ala Ile Ile Ser Met Asn Leu Tyr Ser Ser 
    130                 135                 140                 


Ile Cys Phe Leu Met Leu Val Ser Ile Asp Arg Tyr Leu Ala Leu Val 
145                 150                 155                 160 


Lys Thr Met Ser Met Gly Arg Met Arg Gly Val Arg Trp Ala Lys Leu 
                165                 170                 175     


Tyr Ser Leu Val Ile Trp Gly Cys Thr Leu Leu Leu Ser Ser Pro Met 
            180                 185                 190         


Leu Val Phe Arg Thr Met Lys Glu Tyr Ser Asp Glu Gly His Asn Val 
        195                 200                 205             


Thr Ala Cys Val Ile Ser Tyr Pro Ser Leu Ile Trp Glu Val Phe Thr 
    210                 215                 220                 


Asn Met Leu Leu Asn Val Val Gly Phe Leu Leu Pro Leu Ser Val Ile 
225                 230                 235                 240 


Thr Phe Cys Thr Met Gln Ile Met Gln Val Leu Arg Asn Asn Glu Met 
                245                 250                 255     


Gln Lys Phe Lys Glu Ile Gln Thr Glu Arg Arg Ala Thr Val Leu Val 
            260                 265                 270         


Leu Val Val Leu Leu Leu Phe Ile Ile Cys Trp Leu Pro Phe Gln Ile 
        275                 280                 285             


Ser Thr Phe Leu Asp Thr Leu His Arg Leu Gly Ile Leu Ser Ser Cys 
    290                 295                 300                 


Gln Asp Glu Arg Ile Ile Asp Val Ile Thr Gln Ile Ala Ser Phe Met 
305                 310                 315                 320 


Ala Tyr Ser Asn Ser Cys Leu Asn Pro Leu Val Tyr Val Ile Val Gly 
                325                 330                 335     


Lys Arg Phe Arg Lys Lys Ser Trp Glu Val Tyr Gln Gly Val Cys Gln 
            340                 345                 350         


Lys Gly Gly Cys Arg Ser Glu Pro Ile Gln Met Glu Asn Ser Met Gly 
        355                 360                 365             


Thr Leu Arg Thr Ser Ile Ser Val Glu Arg Gln Ile His Lys Leu Gln 
    370                 375                 380                 


Asp Trp Ala Gly Ser Arg Gln 
385                 390     


<210>  178
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  178

Met Ala Arg Leu Ala Leu Ser Pro Val Pro Ser His Trp Met Val Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ser Ala Glu Pro Val Pro Ala Ala Arg Ser Glu 
            20                  25                  30          


Asp Arg Tyr Arg Asn Pro Lys Gly Ser Ala Cys Ser Arg Ile Trp Gln 
        35                  40                  45              


Ser Pro Arg Phe Ile Ala Arg Lys Arg Gly Phe Thr Val Lys Met His 
    50                  55                  60                  


Cys Tyr Met Asn Ser Ala Ser Gly Asn Val Ser Trp Leu Trp Lys Gln 
65                  70                  75                  80  


Glu Met Asp Glu Asn Pro Gln Gln Leu Lys Leu Glu Lys Gly Arg Met 
                85                  90                  95      


Glu Glu Ser Gln Asn Glu Ser Leu Ala Thr Leu Thr Ile Gln Gly Ile 
            100                 105                 110         


Arg Phe Glu Asp Asn Gly Ile Tyr Phe Cys Gln Gln Lys Cys Asn Asn 
        115                 120                 125             


Thr Ser Glu Val Tyr Gln Gly Cys Gly Thr Glu Leu Arg Val Met Gly 
    130                 135                 140                 


Phe Ser Thr Leu Ala Gln Leu Lys Gln Arg Asn Thr Leu Lys Asp Gly 
145                 150                 155                 160 


Ile Ile Met Ile Gln Thr Leu Leu Ile Ile Leu Phe Ile Ile Val Pro 
                165                 170                 175     


Ile Phe Leu Leu Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu Glu 
            180                 185                 190         


Asp His Thr Tyr Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr Glu 
        195                 200                 205             


Asp Ile Val Thr Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly Glu 
    210                 215                 220                 


His Pro Gly Gln Glu 
225                 


<210>  179
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  179

Met Ala Trp Ser Leu Gly Ser Trp Leu Gly Gly Cys Leu Leu Val Ser 
1               5                   10                  15      


Ala Leu Gly Met Val Pro Pro Pro Glu Asn Val Arg Met Asn Ser Val 
            20                  25                  30          


Asn Phe Lys Asn Ile Leu Gln Trp Glu Ser Pro Ala Phe Ala Lys Gly 
        35                  40                  45              


Asn Leu Thr Phe Thr Ala Gln Tyr Leu Ser Tyr Arg Ile Phe Gln Asp 
    50                  55                  60                  


Lys Cys Met Asn Thr Thr Leu Thr Glu Cys Asp Phe Ser Ser Leu Ser 
65                  70                  75                  80  


Lys Tyr Gly Asp His Thr Leu Arg Val Arg Ala Glu Phe Ala Asp Glu 
                85                  90                  95      


His Ser Asp Trp Val Asn Ile Thr Phe Cys Pro Val Asp Asp Thr Ile 
            100                 105                 110         


Ile Gly Pro Pro Gly Met Gln Val Glu Val Leu Ala Asp Ser Leu His 
        115                 120                 125             


Met Arg Phe Leu Ala Pro Lys Ile Glu Asn Glu Tyr Glu Thr Trp Thr 
    130                 135                 140                 


Met Lys Asn Val Tyr Asn Ser Trp Thr Tyr Asn Val Gln Tyr Trp Lys 
145                 150                 155                 160 


Asn Gly Thr Asp Glu Lys Phe Gln Ile Thr Pro Gln Tyr Asp Phe Glu 
                165                 170                 175     


Val Leu Arg Asn Leu Glu Pro Trp Thr Thr Tyr Cys Val Gln Val Arg 
            180                 185                 190         


Gly Phe Leu Pro Asp Arg Asn Lys Ala Gly Glu Trp Ser Glu Pro Val 
        195                 200                 205             


Cys Glu Gln Thr Thr His Asp Glu Thr Val Pro Ser Trp Met Val Ala 
    210                 215                 220                 


Val Ile Leu Met Ala Ser Val Phe Met Val Cys Leu Ala Leu Leu Gly 
225                 230                 235                 240 


Cys Phe Ala Leu Leu Trp Cys Val Tyr Lys Lys Thr Lys Tyr Ala Phe 
                245                 250                 255     


Ser Pro Arg Asn Ser Leu Pro Gln His Leu Lys Glu Phe Leu Gly His 
            260                 265                 270         


Pro His His Asn Thr Leu Leu Phe Phe Ser Phe Pro Leu Ser Asp Glu 
        275                 280                 285             


Asn Asp Val Phe Asp Lys Leu Ser Val Ile Ala Glu Asp Ser Glu Ser 
    290                 295                 300                 


Gly Lys Gln Asn Pro Gly Asp Ser Cys Ser Leu Gly Thr Pro Pro Gly 
305                 310                 315                 320 


Gln Gly Pro Gln Ser 
                325 


<210>  180
<211>  557
<212>  PRT
<213>  Homo sapiens

<400>  180

Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val Ala Val 
1               5                   10                  15      


Ala Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu Lys Ser 
            20                  25                  30          


Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg 
        35                  40                  45              


Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp 
    50                  55                  60                  


Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln 
65                  70                  75                  80  


Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val 
                85                  90                  95      


Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser 
            100                 105                 110         


Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile 
        115                 120                 125             


Gly Pro Pro Glu Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile 
    130                 135                 140                 


His Ile Ser Pro Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly 
145                 150                 155                 160 


Leu Ser Phe Thr Tyr Ser Leu Val Ile Trp Lys Asn Ser Ser Gly Val 
                165                 170                 175     


Glu Glu Arg Ile Glu Asn Ile Tyr Ser Arg His Lys Ile Tyr Lys Leu 
            180                 185                 190         


Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr 
        195                 200                 205             


Ser Trp Lys Ile Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr 
    210                 215                 220                 


Val Glu Asn Glu Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln 
225                 230                 235                 240 


Asn Gln Asn Tyr Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr 
                245                 250                 255     


Phe Gln Val Gln Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn 
            260                 265                 270         


His Leu Tyr Lys Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr 
        275                 280                 285             


Thr Gln Cys Val Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu 
    290                 295                 300                 


Leu Arg Val Gln Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu 
305                 310                 315                 320 


Glu Ile Lys Phe Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val 
                325                 330                 335     


Phe Asn Ile Arg Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala 
            340                 345                 350         


Pro Lys Gln Ser Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile 
        355                 360                 365             


Tyr Glu Ile Ile Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile 
    370                 375                 380                 


Ile Glu Lys Lys Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr 
385                 390                 395                 400 


Val Tyr Cys Val Lys Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn 
                405                 410                 415     


Lys Ser Ser Val Phe Ser Asp Ala Val Cys Glu Lys Thr Lys Pro Gly 
            420                 425                 430         


Asn Thr Ser Lys Ile Trp Leu Ile Val Gly Ile Cys Ile Ala Leu Phe 
        435                 440                 445             


Ala Leu Pro Phe Val Ile Tyr Ala Ala Lys Val Phe Leu Arg Cys Ile 
    450                 455                 460                 


Asn Tyr Val Phe Phe Pro Ser Leu Lys Pro Ser Ser Ser Ile Asp Glu 
465                 470                 475                 480 


Tyr Phe Ser Glu Gln Pro Leu Lys Asn Leu Leu Leu Ser Thr Ser Glu 
                485                 490                 495     


Glu Gln Ile Glu Lys Cys Phe Ile Ile Glu Asn Ile Ser Thr Ile Ala 
            500                 505                 510         


Thr Val Glu Glu Thr Asn Gln Thr Asp Glu Asp His Lys Lys Tyr Ser 
        515                 520                 525             


Ser Gln Thr Ser Gln Asp Ser Gly Asn Tyr Ser Asn Glu Asp Glu Ser 
    530                 535                 540                 


Glu Ser Lys Thr Ser Glu Glu Leu Gln Gln Asp Phe Val 
545                 550                 555         


<210>  181
<211>  1152
<212>  PRT
<213>  Homo sapiens

<400>  181

Met Ala Leu Arg Val Leu Leu Leu Thr Ala Leu Thr Leu Cys His Gly 
1               5                   10                  15      


Phe Asn Leu Asp Thr Glu Asn Ala Met Thr Phe Gln Glu Asn Ala Arg 
            20                  25                  30          


Gly Phe Gly Gln Ser Val Val Gln Leu Gln Gly Ser Arg Val Val Val 
        35                  40                  45              


Gly Ala Pro Gln Glu Ile Val Ala Ala Asn Gln Arg Gly Ser Leu Tyr 
    50                  55                  60                  


Gln Cys Asp Tyr Ser Thr Gly Ser Cys Glu Pro Ile Arg Leu Gln Val 
65                  70                  75                  80  


Pro Val Glu Ala Val Asn Met Ser Leu Gly Leu Ser Leu Ala Ala Thr 
                85                  90                  95      


Thr Ser Pro Pro Gln Leu Leu Ala Cys Gly Pro Thr Val His Gln Thr 
            100                 105                 110         


Cys Ser Glu Asn Thr Tyr Val Lys Gly Leu Cys Phe Leu Phe Gly Ser 
        115                 120                 125             


Asn Leu Arg Gln Gln Pro Gln Lys Phe Pro Glu Ala Leu Arg Gly Cys 
    130                 135                 140                 


Pro Gln Glu Asp Ser Asp Ile Ala Phe Leu Ile Asp Gly Ser Gly Ser 
145                 150                 155                 160 


Ile Ile Pro His Asp Phe Arg Arg Met Lys Glu Phe Val Ser Thr Val 
                165                 170                 175     


Met Glu Gln Leu Lys Lys Ser Lys Thr Leu Phe Ser Leu Met Gln Tyr 
            180                 185                 190         


Ser Glu Glu Phe Arg Ile His Phe Thr Phe Lys Glu Phe Gln Asn Asn 
        195                 200                 205             


Pro Asn Pro Arg Ser Leu Val Lys Pro Ile Thr Gln Leu Leu Gly Arg 
    210                 215                 220                 


Thr His Thr Ala Thr Gly Ile Arg Lys Val Val Arg Glu Leu Phe Asn 
225                 230                 235                 240 


Ile Thr Asn Gly Ala Arg Lys Asn Ala Phe Lys Ile Leu Val Val Ile 
                245                 250                 255     


Thr Asp Gly Glu Lys Phe Gly Asp Pro Leu Gly Tyr Glu Asp Val Ile 
            260                 265                 270         


Pro Glu Ala Asp Arg Glu Gly Val Ile Arg Tyr Val Ile Gly Val Gly 
        275                 280                 285             


Asp Ala Phe Arg Ser Glu Lys Ser Arg Gln Glu Leu Asn Thr Ile Ala 
    290                 295                 300                 


Ser Lys Pro Pro Arg Asp His Val Phe Gln Val Asn Asn Phe Glu Ala 
305                 310                 315                 320 


Leu Lys Thr Ile Gln Asn Gln Leu Arg Glu Lys Ile Phe Ala Ile Glu 
                325                 330                 335     


Gly Thr Gln Thr Gly Ser Ser Ser Ser Phe Glu His Glu Met Ser Gln 
            340                 345                 350         


Glu Gly Phe Ser Ala Ala Ile Thr Ser Asn Gly Pro Leu Leu Ser Thr 
        355                 360                 365             


Val Gly Ser Tyr Asp Trp Ala Gly Gly Val Phe Leu Tyr Thr Ser Lys 
    370                 375                 380                 


Glu Lys Ser Thr Phe Ile Asn Met Thr Arg Val Asp Ser Asp Met Asn 
385                 390                 395                 400 


Asp Ala Tyr Leu Gly Tyr Ala Ala Ala Ile Ile Leu Arg Asn Arg Val 
                405                 410                 415     


Gln Ser Leu Val Leu Gly Ala Pro Arg Tyr Gln His Ile Gly Leu Val 
            420                 425                 430         


Ala Met Phe Arg Gln Asn Thr Gly Met Trp Glu Ser Asn Ala Asn Val 
        435                 440                 445             


Lys Gly Thr Gln Ile Gly Ala Tyr Phe Gly Ala Ser Leu Cys Ser Val 
    450                 455                 460                 


Asp Val Asp Ser Asn Gly Ser Thr Asp Leu Val Leu Ile Gly Ala Pro 
465                 470                 475                 480 


His Tyr Tyr Glu Gln Thr Arg Gly Gly Gln Val Ser Val Cys Pro Leu 
                485                 490                 495     


Pro Arg Gly Arg Ala Arg Trp Gln Cys Asp Ala Val Leu Tyr Gly Glu 
            500                 505                 510         


Gln Gly Gln Pro Trp Gly Arg Phe Gly Ala Ala Leu Thr Val Leu Gly 
        515                 520                 525             


Asp Val Asn Gly Asp Lys Leu Thr Asp Val Ala Ile Gly Ala Pro Gly 
    530                 535                 540                 


Glu Glu Asp Asn Arg Gly Ala Val Tyr Leu Phe His Gly Thr Ser Gly 
545                 550                 555                 560 


Ser Gly Ile Ser Pro Ser His Ser Gln Arg Ile Ala Gly Ser Lys Leu 
                565                 570                 575     


Ser Pro Arg Leu Gln Tyr Phe Gly Gln Ser Leu Ser Gly Gly Gln Asp 
            580                 585                 590         


Leu Thr Met Asp Gly Leu Val Asp Leu Thr Val Gly Ala Gln Gly His 
        595                 600                 605             


Val Leu Leu Leu Arg Ser Gln Pro Val Leu Arg Val Lys Ala Ile Met 
    610                 615                 620                 


Glu Phe Asn Pro Arg Glu Val Ala Arg Asn Val Phe Glu Cys Asn Asp 
625                 630                 635                 640 


Gln Val Val Lys Gly Lys Glu Ala Gly Glu Val Arg Val Cys Leu His 
                645                 650                 655     


Val Gln Lys Ser Thr Arg Asp Arg Leu Arg Glu Gly Gln Ile Gln Ser 
            660                 665                 670         


Val Val Thr Tyr Asp Leu Ala Leu Asp Ser Gly Arg Pro His Ser Arg 
        675                 680                 685             


Ala Val Phe Asn Glu Thr Lys Asn Ser Thr Arg Arg Gln Thr Gln Val 
    690                 695                 700                 


Leu Gly Leu Thr Gln Thr Cys Glu Thr Leu Lys Leu Gln Leu Pro Asn 
705                 710                 715                 720 


Cys Ile Glu Asp Pro Val Ser Pro Ile Val Leu Arg Leu Asn Phe Ser 
                725                 730                 735     


Leu Val Gly Thr Pro Leu Ser Ala Phe Gly Asn Leu Arg Pro Val Leu 
            740                 745                 750         


Ala Glu Asp Ala Gln Arg Leu Phe Thr Ala Leu Phe Pro Phe Glu Lys 
        755                 760                 765             


Asn Cys Gly Asn Asp Asn Ile Cys Gln Asp Asp Leu Ser Ile Thr Phe 
    770                 775                 780                 


Ser Phe Met Ser Leu Asp Cys Leu Val Val Gly Gly Pro Arg Glu Phe 
785                 790                 795                 800 


Asn Val Thr Val Thr Val Arg Asn Asp Gly Glu Asp Ser Tyr Arg Thr 
                805                 810                 815     


Gln Val Thr Phe Phe Phe Pro Leu Asp Leu Ser Tyr Arg Lys Val Ser 
            820                 825                 830         


Thr Leu Gln Asn Gln Arg Ser Gln Arg Ser Trp Arg Leu Ala Cys Glu 
        835                 840                 845             


Ser Ala Ser Ser Thr Glu Val Ser Gly Ala Leu Lys Ser Thr Ser Cys 
    850                 855                 860                 


Ser Ile Asn His Pro Ile Phe Pro Glu Asn Ser Glu Val Thr Phe Asn 
865                 870                 875                 880 


Ile Thr Phe Asp Val Asp Ser Lys Ala Ser Leu Gly Asn Lys Leu Leu 
                885                 890                 895     


Leu Lys Ala Asn Val Thr Ser Glu Asn Asn Met Pro Arg Thr Asn Lys 
            900                 905                 910         


Thr Glu Phe Gln Leu Glu Leu Pro Val Lys Tyr Ala Val Tyr Met Val 
        915                 920                 925             


Val Thr Ser His Gly Val Ser Thr Lys Tyr Leu Asn Phe Thr Ala Ser 
    930                 935                 940                 


Glu Asn Thr Ser Arg Val Met Gln His Gln Tyr Gln Val Ser Asn Leu 
945                 950                 955                 960 


Gly Gln Arg Ser Leu Pro Ile Ser Leu Val Phe Leu Val Pro Val Arg 
                965                 970                 975     


Leu Asn Gln Thr Val Ile Trp Asp Arg Pro Gln Val Thr Phe Ser Glu 
            980                 985                 990         


Asn Leu Ser Ser Thr Cys His Thr  Lys Glu Arg Leu Pro  Ser His Ser 
        995                 1000                 1005             


Asp Phe  Leu Ala Glu Leu Arg  Lys Ala Pro Val Val  Asn Cys Ser 
    1010                 1015                 1020             


Ile Ala  Val Cys Gln Arg Ile  Gln Cys Asp Ile Pro  Phe Phe Gly 
    1025                 1030                 1035             


Ile Gln  Glu Glu Phe Asn Ala  Thr Leu Lys Gly Asn  Leu Ser Phe 
    1040                 1045                 1050             


Asp Trp  Tyr Ile Lys Thr Ser  His Asn His Leu Leu  Ile Val Ser 
    1055                 1060                 1065             


Thr Ala  Glu Ile Leu Phe Asn  Asp Ser Val Phe Thr  Leu Leu Pro 
    1070                 1075                 1080             


Gly Gln  Gly Ala Phe Val Arg  Ser Gln Thr Glu Thr  Lys Val Glu 
    1085                 1090                 1095             


Pro Phe  Glu Val Pro Asn Pro  Leu Pro Leu Ile Val  Gly Ser Ser 
    1100                 1105                 1110             


Val Gly  Gly Leu Leu Leu Leu  Ala Leu Ile Thr Ala  Ala Leu Tyr 
    1115                 1120                 1125             


Lys Leu  Gly Phe Phe Lys Arg  Gln Tyr Lys Asp Met  Met Ser Glu 
    1130                 1135                 1140             


Gly Gly  Pro Pro Gly Ala Glu  Pro Gln 
    1145                 1150         


<210>  182
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  182

Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met 
1               5                   10                  15      


Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 
            20                  25                  30          


Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile 
        35                  40                  45              


Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala Ala Ser Arg Asp 
    50                  55                  60                  


Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala 
65                  70                  75                  80  


Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr 
                85                  90                  95      


Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe 
            100                 105                 110         


Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly 
        115                 120                 125             


Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp 
    130                 135                 140                 


Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu 
145                 150                 155                 160 


Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp 
                165                 170                 175     


Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn 
            180                 185                 190         


Gly Gly Trp Asp Ala Phe Val Glu Leu Tyr Gly Pro Ser Met Arg Pro 
        195                 200                 205             


Leu Phe Asp Phe Ser Trp Leu Ser Leu Lys Thr Leu Leu Ser Leu Ala 
    210                 215                 220                 


Leu Val Gly Ala Cys Ile Thr Leu Gly Ala Tyr Leu Gly His Lys 
225                 230                 235                 


<210>  183
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  183

Met Ser Asn Ile Thr Asp Pro Gln Met Trp Asp Phe Asp Asp Leu Asn 
1               5                   10                  15      


Phe Thr Gly Met Pro Pro Ala Asp Glu Asp Tyr Ser Pro Cys Met Leu 
            20                  25                  30          


Glu Thr Glu Thr Leu Asn Lys Tyr Val Val Ile Ile Ala Tyr Ala Leu 
        35                  40                  45              


Val Phe Leu Leu Ser Leu Leu Gly Asn Ser Leu Val Met Leu Val Ile 
    50                  55                  60                  


Leu Tyr Ser Arg Val Gly Arg Ser Val Thr Asp Val Tyr Leu Leu Asn 
65                  70                  75                  80  


Leu Ala Leu Ala Asp Leu Leu Phe Ala Leu Thr Leu Pro Ile Trp Ala 
                85                  90                  95      


Ala Ser Lys Val Asn Gly Trp Ile Phe Gly Thr Phe Leu Cys Lys Val 
            100                 105                 110         


Val Ser Leu Leu Lys Glu Val Asn Phe Tyr Ser Gly Ile Leu Leu Leu 
        115                 120                 125             


Ala Cys Ile Ser Val Asp Arg Tyr Leu Ala Ile Val His Ala Thr Arg 
    130                 135                 140                 


Thr Leu Thr Gln Lys Arg His Leu Val Lys Phe Val Cys Leu Gly Cys 
145                 150                 155                 160 


Trp Gly Leu Ser Met Asn Leu Ser Leu Pro Phe Phe Leu Phe Arg Gln 
                165                 170                 175     


Ala Tyr His Pro Asn Asn Ser Ser Pro Val Cys Tyr Glu Val Leu Gly 
            180                 185                 190         


Asn Asp Thr Ala Lys Trp Arg Met Val Leu Arg Ile Leu Pro His Thr 
        195                 200                 205             


Phe Gly Phe Ile Val Pro Leu Phe Val Met Leu Phe Cys Tyr Gly Phe 
    210                 215                 220                 


Thr Leu Arg Thr Leu Phe Lys Ala His Met Gly Gln Lys His Arg Ala 
225                 230                 235                 240 


Met Arg Val Ile Phe Ala Val Val Leu Ile Phe Leu Leu Cys Trp Leu 
                245                 250                 255     


Pro Tyr Asn Leu Val Leu Leu Ala Asp Thr Leu Met Arg Thr Gln Val 
            260                 265                 270         


Ile Gln Glu Ser Cys Glu Arg Arg Asn Asn Ile Gly Arg Ala Leu Asp 
        275                 280                 285             


Ala Thr Glu Ile Leu Gly Phe Leu His Ser Cys Leu Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Ala Phe Ile Gly Gln Asn Phe Arg His Gly Phe Leu Lys Ile Leu 
305                 310                 315                 320 


Ala Met His Gly Leu Val Ser Lys Glu Phe Leu Ala Arg His Arg Val 
                325                 330                 335     


Thr Ser Tyr Thr Ser Ser Ser Val Asn Val Ser Ser Asn Leu 
            340                 345                 350 


<210>  184
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  184

Met Gln Gln Pro Phe Asn Tyr Pro Tyr Pro Gln Ile Tyr Trp Val Asp 
1               5                   10                  15      


Ser Ser Ala Ser Ser Pro Trp Ala Pro Pro Gly Thr Val Leu Pro Cys 
            20                  25                  30          


Pro Thr Ser Val Pro Arg Arg Pro Gly Gln Arg Arg Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro 
    50                  55                  60                  


Pro Leu Pro Leu Pro Pro Leu Lys Lys Arg Gly Asn His Ser Thr Gly 
65                  70                  75                  80  


Leu Cys Leu Leu Val Met Phe Phe Met Val Leu Val Ala Leu Val Gly 
                85                  90                  95      


Leu Gly Leu Gly Met Phe Gln Leu Phe His Leu Gln Lys Glu Leu Ala 
            100                 105                 110         


Glu Leu Arg Glu Ser Thr Ser Gln Met His Thr Ala Ser Ser Leu Glu 
        115                 120                 125             


Lys Gln Ile Gly His Pro Ser Pro Pro Pro Glu Lys Lys Glu Leu Arg 
    130                 135                 140                 


Lys Val Ala His Leu Thr Gly Lys Ser Asn Ser Arg Ser Met Pro Leu 
145                 150                 155                 160 


Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu Leu Ser Gly Val Lys Tyr 
                165                 170                 175     


Lys Lys Gly Gly Leu Val Ile Asn Glu Thr Gly Leu Tyr Phe Val Tyr 
            180                 185                 190         


Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn Leu Pro Leu Ser 
        195                 200                 205             


His Lys Val Tyr Met Arg Asn Ser Lys Tyr Pro Gln Asp Leu Val Met 
    210                 215                 220                 


Met Glu Gly Lys Met Met Ser Tyr Cys Thr Thr Gly Gln Met Trp Ala 
225                 230                 235                 240 


Arg Ser Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr Ser Ala Asp His 
                245                 250                 255     


Leu Tyr Val Asn Val Ser Glu Leu Ser Leu Val Asn Phe Glu Glu Ser 
            260                 265                 270         


Gln Thr Phe Phe Gly Leu Tyr Lys Leu 
        275                 280     


<210>  185
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  185

Met Ala Phe Val Cys Leu Ala Ile Gly Cys Leu Tyr Thr Phe Leu Ile 
1               5                   10                  15      


Ser Thr Thr Phe Gly Cys Thr Ser Ser Ser Asp Thr Glu Ile Lys Val 
            20                  25                  30          


Asn Pro Pro Gln Asp Phe Glu Ile Val Asp Pro Gly Tyr Leu Gly Tyr 
        35                  40                  45              


Leu Tyr Leu Gln Trp Gln Pro Pro Leu Ser Leu Asp His Phe Lys Glu 
    50                  55                  60                  


Cys Thr Val Glu Tyr Glu Leu Lys Tyr Arg Asn Ile Gly Ser Glu Thr 
65                  70                  75                  80  


Trp Lys Thr Ile Ile Thr Lys Asn Leu His Tyr Lys Asp Gly Phe Asp 
                85                  90                  95      


Leu Asn Lys Gly Ile Glu Ala Lys Ile His Thr Leu Leu Pro Trp Gln 
            100                 105                 110         


Cys Thr Asn Gly Ser Glu Val Gln Ser Ser Trp Ala Glu Thr Thr Tyr 
        115                 120                 125             


Trp Ile Ser Pro Gln Gly Ile Pro Glu Thr Lys Val Gln Asp Met Asp 
    130                 135                 140                 


Cys Val Tyr Tyr Asn Trp Gln Tyr Leu Leu Cys Ser Trp Lys Pro Gly 
145                 150                 155                 160 


Ile Gly Val Leu Leu Asp Thr Asn Tyr Asn Leu Phe Tyr Trp Tyr Glu 
                165                 170                 175     


Gly Leu Asp His Ala Leu Gln Cys Val Asp Tyr Ile Lys Ala Asp Gly 
            180                 185                 190         


Gln Asn Ile Gly Cys Arg Phe Pro Tyr Leu Glu Ala Ser Asp Tyr Lys 
        195                 200                 205             


Asp Phe Tyr Ile Cys Val Asn Gly Ser Ser Glu Asn Lys Pro Ile Arg 
    210                 215                 220                 


Ser Ser Tyr Phe Thr Phe Gln Leu Gln Asn Ile Val Lys Pro Leu Pro 
225                 230                 235                 240 


Pro Val Tyr Leu Thr Phe Thr Arg Glu Ser Ser Cys Glu Ile Lys Leu 
                245                 250                 255     


Lys Trp Ser Ile Pro Leu Gly Pro Ile Pro Ala Arg Cys Phe Asp Tyr 
            260                 265                 270         


Glu Ile Glu Ile Arg Glu Asp Asp Thr Thr Leu Val Thr Ala Thr Val 
        275                 280                 285             


Glu Asn Glu Thr Tyr Thr Leu Lys Thr Thr Asn Glu Thr Arg Gln Leu 
    290                 295                 300                 


Cys Phe Val Val Arg Ser Lys Val Asn Ile Tyr Cys Ser Asp Asp Gly 
305                 310                 315                 320 


Ile Trp Ser Glu Trp Ser Asp Lys Gln Cys Trp Glu Gly Glu Asp Leu 
                325                 330                 335     


Ser Lys Lys Thr Leu Leu Arg Phe Trp Leu Pro Phe Gly Phe Ile Leu 
            340                 345                 350         


Ile Leu Val Ile Phe Val Thr Gly Leu Leu Leu Arg Lys Pro Asn Thr 
        355                 360                 365             


Tyr Pro Lys Met Ile Pro Glu Phe Phe Cys Asp Thr 
    370                 375                 380 


<210>  186
<211>  2489
<212>  PRT
<213>  Homo sapiens

<400>  186

Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
1               5                   10                  15      


Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
            20                  25                  30          


Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
        35                  40                  45              


Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro 
    50                  55                  60                  


Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
65                  70                  75                  80  


Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys 
                85                  90                  95      


Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
            100                 105                 110         


Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
        115                 120                 125             


Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr 
    130                 135                 140                 


Cys Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile 
145                 150                 155                 160 


Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp 
                165                 170                 175     


Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr 
            180                 185                 190         


Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
        195                 200                 205             


Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile 
    210                 215                 220                 


Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro 
225                 230                 235                 240 


Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
                245                 250                 255     


Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met 
            260                 265                 270         


Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
        275                 280                 285             


Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
    290                 295                 300                 


His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
305                 310                 315                 320 


Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala 
                325                 330                 335     


Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr 
            340                 345                 350         


Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly 
        355                 360                 365             


Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
    370                 375                 380                 


Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
385                 390                 395                 400 


Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
                405                 410                 415     


Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His 
            420                 425                 430         


Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Thr Val Asn Tyr 
        435                 440                 445             


Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly 
    450                 455                 460                 


Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp 
465                 470                 475                 480 


Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro 
                485                 490                 495     


Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp 
            500                 505                 510         


Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
        515                 520                 525             


Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser 
    530                 535                 540                 


Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro 
545                 550                 555                 560 


Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg 
                565                 570                 575     


Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser 
            580                 585                 590         


Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro 
        595                 600                 605             


Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn 
    610                 615                 620                 


Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val 
625                 630                 635                 640 


Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu 
                645                 650                 655     


Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val 
            660                 665                 670         


Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys 
        675                 680                 685             


Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser 
    690                 695                 700                 


Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe 
705                 710                 715                 720 


Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp 
                725                 730                 735     


Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp 
            740                 745                 750         


Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro 
        755                 760                 765             


Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly 
    770                 775                 780                 


Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala 
785                 790                 795                 800 


Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu 
                805                 810                 815     


Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val 
            820                 825                 830         


Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser 
        835                 840                 845             


Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro 
    850                 855                 860                 


Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly 
865                 870                 875                 880 


Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Thr Val 
                885                 890                 895     


Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu 
            900                 905                 910         


Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly 
        915                 920                 925             


Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln 
    930                 935                 940                 


Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala 
945                 950                 955                 960 


Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu 
                965                 970                 975     


Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp 
            980                 985                 990         


Ser Ser Pro Lys Asp Val Cys Lys  Arg Lys Ser Cys Lys  Thr Pro Pro 
        995                 1000                 1005             


Asp Pro  Val Asn Gly Met Val  His Val Ile Thr Asp  Ile Gln Val 
    1010                 1015                 1020             


Gly Ser  Arg Ile Asn Tyr Ser  Cys Thr Thr Gly His  Arg Leu Ile 
    1025                 1030                 1035             


Gly His  Ser Ser Ala Glu Cys  Ile Leu Ser Gly Asn  Ala Ala His 
    1040                 1045                 1050             


Trp Ser  Thr Lys Pro Pro Ile  Cys Gln Arg Ile Pro  Cys Gly Leu 
    1055                 1060                 1065             


Pro Pro  Thr Ile Ala Asn Gly  Asp Phe Ile Ser Thr  Asn Arg Glu 
    1070                 1075                 1080             


Asn Phe  His Tyr Gly Ser Val  Val Thr Tyr Arg Cys  Asn Pro Gly 
    1085                 1090                 1095             


Ser Gly  Gly Arg Lys Val Phe  Glu Leu Val Gly Glu  Pro Ser Ile 
    1100                 1105                 1110             


Tyr Cys  Thr Ser Asn Asp Asp  Gln Val Gly Ile Trp  Ser Gly Pro 
    1115                 1120                 1125             


Ala Pro  Gln Cys Ile Ile Pro  Asn Lys Cys Thr Pro  Pro Asn Val 
    1130                 1135                 1140             


Glu Asn  Gly Ile Leu Val Ser  Asp Asn Arg Ser Leu  Phe Ser Leu 
    1145                 1150                 1155             


Asn Glu  Val Val Glu Phe Arg  Cys Gln Pro Gly Phe  Val Met Lys 
    1160                 1165                 1170             


Gly Pro  Arg Arg Val Lys Cys  Gln Ala Leu Asn Lys  Trp Glu Pro 
    1175                 1180                 1185             


Glu Leu  Pro Ser Cys Ser Arg  Val Cys Gln Pro Pro  Pro Asp Val 
    1190                 1195                 1200             


Leu His  Ala Glu Arg Thr Gln  Arg Asp Lys Asp Asn  Phe Ser Pro 
    1205                 1210                 1215             


Gly Gln  Glu Val Phe Tyr Ser  Cys Glu Pro Gly Tyr  Asp Leu Arg 
    1220                 1225                 1230             


Gly Ala  Ala Ser Met Arg Cys  Thr Pro Gln Gly Asp  Trp Ser Pro 
    1235                 1240                 1245             


Ala Ala  Pro Thr Cys Glu Val  Lys Ser Cys Asp Asp  Phe Met Gly 
    1250                 1255                 1260             


Gln Leu  Leu Asn Gly Arg Val  Leu Phe Pro Val Asn  Leu Gln Leu 
    1265                 1270                 1275             


Gly Ala  Lys Val Asp Phe Val  Cys Asp Glu Gly Phe  Gln Leu Lys 
    1280                 1285                 1290             


Gly Ser  Ser Ala Ser Tyr Cys  Val Leu Ala Gly Met  Glu Ser Leu 
    1295                 1300                 1305             


Trp Asn  Ser Ser Val Pro Val  Cys Glu Gln Ile Phe  Cys Pro Ser 
    1310                 1315                 1320             


Pro Pro  Val Ile Pro Asn Gly  Arg His Thr Gly Lys  Pro Leu Glu 
    1325                 1330                 1335             


Val Phe  Pro Phe Gly Lys Ala  Val Asn Tyr Thr Cys  Asp Pro His 
    1340                 1345                 1350             


Pro Asp  Arg Gly Thr Ser Phe  Asp Leu Ile Gly Glu  Ser Thr Ile 
    1355                 1360                 1365             


Arg Cys  Thr Ser Asp Pro Gln  Gly Asn Gly Val Trp  Ser Ser Pro 
    1370                 1375                 1380             


Ala Pro  Arg Cys Gly Ile Leu  Gly His Cys Gln Ala  Pro Asp His 
    1385                 1390                 1395             


Phe Leu  Phe Ala Lys Leu Lys  Thr Gln Thr Asn Ala  Ser Asp Phe 
    1400                 1405                 1410             


Pro Ile  Gly Thr Ser Leu Lys  Tyr Glu Cys Arg Pro  Glu Tyr Tyr 
    1415                 1420                 1425             


Gly Arg  Pro Phe Ser Ile Thr  Cys Leu Asp Asn Leu  Val Trp Ser 
    1430                 1435                 1440             


Ser Pro  Lys Asp Val Cys Lys  Arg Lys Ser Cys Lys  Thr Pro Pro 
    1445                 1450                 1455             


Asp Pro  Val Asn Gly Met Val  His Val Ile Thr Asp  Ile Gln Val 
    1460                 1465                 1470             


Gly Ser  Arg Ile Asn Tyr Ser  Cys Thr Thr Gly His  Arg Leu Ile 
    1475                 1480                 1485             


Gly His  Ser Ser Ala Glu Cys  Ile Leu Ser Gly Asn  Thr Ala His 
    1490                 1495                 1500             


Trp Ser  Thr Lys Pro Pro Ile  Cys Gln Arg Ile Pro  Cys Gly Leu 
    1505                 1510                 1515             


Pro Pro  Thr Ile Ala Asn Gly  Asp Phe Ile Ser Thr  Asn Arg Glu 
    1520                 1525                 1530             


Asn Phe  His Tyr Gly Ser Val  Val Thr Tyr Arg Cys  Asn Leu Gly 
    1535                 1540                 1545             


Ser Arg  Gly Arg Lys Val Phe  Glu Leu Val Gly Glu  Pro Ser Ile 
    1550                 1555                 1560             


Tyr Cys  Thr Ser Asn Asp Asp  Gln Val Gly Ile Trp  Ser Gly Pro 
    1565                 1570                 1575             


Ala Pro  Gln Cys Ile Ile Pro  Asn Lys Cys Thr Pro  Pro Asn Val 
    1580                 1585                 1590             


Glu Asn  Gly Ile Leu Val Ser  Asp Asn Arg Ser Leu  Phe Ser Leu 
    1595                 1600                 1605             


Asn Glu  Val Val Glu Phe Arg  Cys Gln Pro Gly Phe  Val Met Lys 
    1610                 1615                 1620             


Gly Pro  Arg Arg Val Lys Cys  Gln Ala Leu Asn Lys  Trp Glu Pro 
    1625                 1630                 1635             


Glu Leu  Pro Ser Cys Ser Arg  Val Cys Gln Pro Pro  Pro Glu Ile 
    1640                 1645                 1650             


Leu His  Gly Glu His Thr Pro  Ser His Gln Asp Asn  Phe Ser Pro 
    1655                 1660                 1665             


Gly Gln  Glu Val Phe Tyr Ser  Cys Glu Pro Gly Tyr  Asp Leu Arg 
    1670                 1675                 1680             


Gly Ala  Ala Ser Leu His Cys  Thr Pro Gln Gly Asp  Trp Ser Pro 
    1685                 1690                 1695             


Glu Ala  Pro Arg Cys Ala Val  Lys Ser Cys Asp Asp  Phe Leu Gly 
    1700                 1705                 1710             


Gln Leu  Pro His Gly Arg Val  Leu Phe Pro Leu Asn  Leu Gln Leu 
    1715                 1720                 1725             


Gly Ala  Lys Val Ser Phe Val  Cys Asp Glu Gly Phe  Arg Leu Lys 
    1730                 1735                 1740             


Gly Ser  Ser Val Ser His Cys  Val Leu Val Gly Met  Arg Ser Leu 
    1745                 1750                 1755             


Trp Asn  Asn Ser Val Pro Val  Cys Glu His Ile Phe  Cys Pro Asn 
    1760                 1765                 1770             


Pro Pro  Ala Ile Leu Asn Gly  Arg His Thr Gly Thr  Pro Ser Gly 
    1775                 1780                 1785             


Asp Ile  Pro Tyr Gly Lys Glu  Ile Ser Tyr Thr Cys  Asp Pro His 
    1790                 1795                 1800             


Pro Asp  Arg Gly Met Thr Phe  Asn Leu Ile Gly Glu  Ser Thr Ile 
    1805                 1810                 1815             


Arg Cys  Thr Ser Asp Pro His  Gly Asn Gly Val Trp  Ser Ser Pro 
    1820                 1825                 1830             


Ala Pro  Arg Cys Glu Leu Ser  Val Arg Ala Gly His  Cys Lys Thr 
    1835                 1840                 1845             


Pro Glu  Gln Phe Pro Phe Ala  Ser Pro Thr Ile Pro  Ile Asn Asp 
    1850                 1855                 1860             


Phe Glu  Phe Pro Val Gly Thr  Ser Leu Asn Tyr Glu  Cys Arg Pro 
    1865                 1870                 1875             


Gly Tyr  Phe Gly Lys Met Phe  Ser Ile Ser Cys Leu  Glu Asn Leu 
    1880                 1885                 1890             


Val Trp  Ser Ser Val Glu Asp  Asn Cys Arg Arg Lys  Ser Cys Gly 
    1895                 1900                 1905             


Pro Pro  Pro Glu Pro Phe Asn  Gly Met Val His Ile  Asn Thr Asp 
    1910                 1915                 1920             


Thr Gln  Phe Gly Ser Thr Val  Asn Tyr Ser Cys Asn  Glu Gly Phe 
    1925                 1930                 1935             


Arg Leu  Ile Gly Ser Pro Ser  Thr Thr Cys Leu Val  Ser Gly Asn 
    1940                 1945                 1950             


Asn Val  Thr Trp Asp Lys Lys  Ala Pro Ile Cys Glu  Ile Ile Ser 
    1955                 1960                 1965             


Cys Glu  Pro Pro Pro Thr Ile  Ser Asn Gly Asp Phe  Tyr Ser Asn 
    1970                 1975                 1980             


Asn Arg  Thr Ser Phe His Asn  Gly Thr Val Val Thr  Tyr Gln Cys 
    1985                 1990                 1995             


His Thr  Gly Pro Asp Gly Glu  Gln Leu Phe Glu Leu  Val Gly Glu 
    2000                 2005                 2010             


Arg Ser  Ile Tyr Cys Thr Ser  Lys Asp Asp Gln Val  Gly Val Trp 
    2015                 2020                 2025             


Ser Ser  Pro Pro Pro Arg Cys  Ile Ser Thr Asn Lys  Cys Thr Ala 
    2030                 2035                 2040             


Pro Glu  Val Glu Asn Ala Ile  Arg Val Pro Gly Asn  Arg Ser Phe 
    2045                 2050                 2055             


Phe Thr  Leu Thr Glu Ile Ile  Arg Phe Arg Cys Gln  Pro Gly Phe 
    2060                 2065                 2070             


Val Met  Val Gly Ser His Thr  Val Gln Cys Gln Thr  Asn Gly Arg 
    2075                 2080                 2085             


Trp Gly  Pro Lys Leu Pro His  Cys Ser Arg Val Cys  Gln Pro Pro 
    2090                 2095                 2100             


Pro Glu  Ile Leu His Gly Glu  His Thr Leu Ser His  Gln Asp Asn 
    2105                 2110                 2115             


Phe Ser  Pro Gly Gln Glu Val  Phe Tyr Ser Cys Glu  Pro Ser Tyr 
    2120                 2125                 2130             


Asp Leu  Arg Gly Ala Ala Ser  Leu His Cys Thr Pro  Gln Gly Asp 
    2135                 2140                 2145             


Trp Ser  Pro Glu Ala Pro Arg  Cys Thr Val Lys Ser  Cys Asp Asp 
    2150                 2155                 2160             


Phe Leu  Gly Gln Leu Pro His  Gly Arg Val Leu Leu  Pro Leu Asn 
    2165                 2170                 2175             


Leu Gln  Leu Gly Ala Lys Val  Ser Phe Val Cys Asp  Glu Gly Phe 
    2180                 2185                 2190             


Arg Leu  Lys Gly Arg Ser Ala  Ser His Cys Val Leu  Ala Gly Met 
    2195                 2200                 2205             


Lys Ala  Leu Trp Asn Ser Ser  Val Pro Val Cys Glu  Gln Ile Phe 
    2210                 2215                 2220             


Cys Pro  Asn Pro Pro Ala Ile  Leu Asn Gly Arg His  Thr Gly Thr 
    2225                 2230                 2235             


Pro Phe  Gly Asp Ile Pro Tyr  Gly Lys Glu Ile Ser  Tyr Ala Cys 
    2240                 2245                 2250             


Asp Thr  His Pro Asp Arg Gly  Met Thr Phe Asn Leu  Ile Gly Glu 
    2255                 2260                 2265             


Ser Ser  Ile Arg Cys Thr Ser  Asp Pro Gln Gly Asn  Gly Val Trp 
    2270                 2275                 2280             


Ser Ser  Pro Ala Pro Arg Cys  Glu Leu Ser Val Pro  Ala Ala Cys 
    2285                 2290                 2295             


Pro His  Pro Pro Lys Ile Gln  Asn Gly His Tyr Ile  Gly Gly His 
    2300                 2305                 2310             


Val Ser  Leu Tyr Leu Pro Gly  Met Thr Ile Ser Tyr  Ile Cys Asp 
    2315                 2320                 2325             


Pro Gly  Tyr Leu Leu Val Gly  Lys Gly Phe Ile Phe  Cys Thr Asp 
    2330                 2335                 2340             


Gln Gly  Ile Trp Ser Gln Leu  Asp His Tyr Cys Lys  Glu Val Asn 
    2345                 2350                 2355             


Cys Ser  Phe Pro Leu Phe Met  Asn Gly Ile Ser Lys  Glu Leu Glu 
    2360                 2365                 2370             


Met Lys  Lys Val Tyr His Tyr  Gly Asp Tyr Val Thr  Leu Lys Cys 
    2375                 2380                 2385             


Glu Asp  Gly Tyr Thr Leu Glu  Gly Ser Pro Trp Ser  Gln Cys Gln 
    2390                 2395                 2400             


Ala Asp  Asp Arg Trp Asp Pro  Pro Leu Ala Lys Cys  Thr Ser Arg 
    2405                 2410                 2415             


Thr His  Asp Ala Leu Ile Val  Gly Thr Leu Ser Gly  Thr Ile Phe 
    2420                 2425                 2430             


Phe Ile  Leu Leu Ile Ile Phe  Leu Ser Trp Ile Ile  Leu Lys His 
    2435                 2440                 2445             


Arg Lys  Gly Asn Asn Ala His  Glu Asn Pro Lys Glu  Val Ala Ile 
    2450                 2455                 2460             


His Leu  His Ser Gln Gly Gly  Ser Ser Val His Pro  Arg Thr Leu 
    2465                 2470                 2475             


Gln Thr  Asn Glu Glu Asn Ser  Arg Val Leu Pro 
    2480                 2485                 


<210>  187
<211>  385
<212>  PRT
<213>  Homo sapiens

<400>  187

Met Gly Cys Arg Arg Thr Arg Glu Gly Pro Ser Lys Ala Met Ile Phe 
1               5                   10                  15      


Pro Trp Lys Cys Gln Ser Thr Gln Arg Asp Leu Trp Asn Ile Phe Lys 
            20                  25                  30          


Leu Trp Gly Trp Thr Met Leu Cys Cys Asp Phe Leu Ala His His Gly 
        35                  40                  45              


Thr Asp Cys Trp Thr Tyr His Tyr Ser Glu Lys Pro Met Asn Trp Gln 
    50                  55                  60                  


Arg Ala Arg Arg Phe Cys Arg Asp Asn Tyr Thr Asp Leu Val Ala Ile 
65                  70                  75                  80  


Gln Asn Lys Ala Glu Ile Glu Tyr Leu Glu Lys Thr Leu Pro Phe Ser 
                85                  90                  95      


Arg Ser Tyr Tyr Trp Ile Gly Ile Arg Lys Ile Gly Gly Ile Trp Thr 
            100                 105                 110         


Trp Val Gly Thr Asn Lys Ser Leu Thr Glu Glu Ala Glu Asn Trp Gly 
        115                 120                 125             


Asp Gly Glu Pro Asn Asn Lys Lys Asn Lys Glu Asp Cys Val Glu Ile 
    130                 135                 140                 


Tyr Ile Lys Arg Asn Lys Asp Ala Gly Lys Trp Asn Asp Asp Ala Cys 
145                 150                 155                 160 


His Lys Leu Lys Ala Ala Leu Cys Tyr Thr Ala Ser Cys Gln Pro Trp 
                165                 170                 175     


Ser Cys Ser Gly His Gly Glu Cys Val Glu Ile Ile Asn Asn Tyr Thr 
            180                 185                 190         


Cys Asn Cys Asp Val Gly Tyr Tyr Gly Pro Gln Cys Gln Phe Val Ile 
        195                 200                 205             


Gln Cys Glu Pro Leu Glu Ala Pro Glu Leu Gly Thr Met Asp Cys Thr 
    210                 215                 220                 


His Pro Leu Gly Asn Phe Ser Phe Ser Ser Gln Cys Ala Phe Ser Cys 
225                 230                 235                 240 


Ser Glu Gly Thr Asn Leu Thr Gly Ile Glu Glu Thr Thr Cys Gly Pro 
                245                 250                 255     


Phe Gly Asn Trp Ser Ser Pro Glu Pro Thr Cys Gln Val Ile Gln Cys 
            260                 265                 270         


Glu Pro Leu Ser Ala Pro Asp Leu Gly Ile Met Asn Cys Ser His Pro 
        275                 280                 285             


Leu Ala Ser Phe Ser Phe Thr Ser Ala Cys Thr Phe Ile Cys Ser Glu 
    290                 295                 300                 


Gly Thr Glu Leu Ile Gly Lys Lys Lys Thr Ile Cys Glu Ser Ser Gly 
305                 310                 315                 320 


Ile Trp Ser Asn Pro Ser Pro Ile Cys Gln Lys Leu Asp Lys Ser Phe 
                325                 330                 335     


Ser Met Ile Lys Glu Gly Asp Tyr Asn Pro Leu Phe Ile Pro Val Ala 
            340                 345                 350         


Val Met Val Thr Ala Phe Ser Gly Leu Ala Phe Ile Ile Trp Leu Ala 
        355                 360                 365             


Arg Arg Leu Lys Lys Gly Lys Lys Ser Lys Arg Ser Met Asn Asp Pro 
    370                 375                 380                 


Tyr 
385 


<210>  188
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  188

Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met 
1               5                   10                  15      


Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 
            20                  25                  30          


Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile 
        35                  40                  45              


Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala Ala Ser Arg Asp 
    50                  55                  60                  


Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala 
65                  70                  75                  80  


Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr 
                85                  90                  95      


Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe 
            100                 105                 110         


Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly 
        115                 120                 125             


Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp 
    130                 135                 140                 


Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu 
145                 150                 155                 160 


Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp 
                165                 170                 175     


Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn 
            180                 185                 190         


Gly Gly Trp Val Gly Ala Leu Gly Asp Val Ser Leu Gly 
        195                 200                 205 


<210>  189
<211>  614
<212>  PRT
<213>  Homo sapiens

<400>  189

Met Arg Pro Pro Gln Cys Leu Leu His Thr Pro Ser Leu Ala Ser Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Trp Leu Leu Gly Gly Gly Val Gly Ala Glu 
            20                  25                  30          


Gly Arg Glu Asp Ala Glu Leu Leu Val Thr Val Arg Gly Gly Arg Leu 
        35                  40                  45              


Arg Gly Ile Arg Leu Lys Thr Pro Gly Gly Pro Val Ser Ala Phe Leu 
    50                  55                  60                  


Gly Ile Pro Phe Ala Glu Pro Pro Met Gly Pro Arg Arg Phe Leu Pro 
65                  70                  75                  80  


Pro Glu Pro Lys Gln Pro Trp Ser Gly Val Val Asp Ala Thr Thr Phe 
                85                  90                  95      


Gln Ser Val Cys Tyr Gln Tyr Val Asp Thr Leu Tyr Pro Gly Phe Glu 
            100                 105                 110         


Gly Thr Glu Met Trp Asn Pro Asn Arg Glu Leu Ser Glu Asp Cys Leu 
        115                 120                 125             


Tyr Leu Asn Val Trp Thr Pro Tyr Pro Arg Pro Thr Ser Pro Thr Pro 
    130                 135                 140                 


Val Leu Val Trp Ile Tyr Gly Gly Gly Phe Tyr Ser Gly Ala Ser Ser 
145                 150                 155                 160 


Leu Asp Val Tyr Asp Gly Arg Phe Leu Val Gln Ala Glu Arg Thr Val 
                165                 170                 175     


Leu Val Ser Met Asn Tyr Arg Val Gly Ala Phe Gly Phe Leu Ala Leu 
            180                 185                 190         


Pro Gly Ser Arg Glu Ala Pro Gly Asn Val Gly Leu Leu Asp Gln Arg 
        195                 200                 205             


Leu Ala Leu Gln Trp Val Gln Glu Asn Val Ala Ala Phe Gly Gly Asp 
    210                 215                 220                 


Pro Thr Ser Val Thr Leu Phe Gly Glu Ser Ala Gly Ala Ala Ser Val 
225                 230                 235                 240 


Gly Met His Leu Leu Ser Pro Pro Ser Arg Gly Leu Phe His Arg Ala 
                245                 250                 255     


Val Leu Gln Ser Gly Ala Pro Asn Gly Pro Trp Ala Thr Val Gly Met 
            260                 265                 270         


Gly Glu Ala Arg Arg Arg Ala Thr Gln Leu Ala His Leu Val Gly Cys 
        275                 280                 285             


Pro Pro Gly Gly Thr Gly Gly Asn Asp Thr Glu Leu Val Ala Cys Leu 
    290                 295                 300                 


Arg Thr Arg Pro Ala Gln Val Leu Val Asn His Glu Trp His Val Leu 
305                 310                 315                 320 


Pro Gln Glu Ser Val Phe Arg Phe Ser Phe Val Pro Val Val Asp Gly 
                325                 330                 335     


Asp Phe Leu Ser Asp Thr Pro Glu Ala Leu Ile Asn Ala Gly Asp Phe 
            340                 345                 350         


His Gly Leu Gln Val Leu Val Gly Val Val Lys Asp Glu Gly Ser Tyr 
        355                 360                 365             


Phe Leu Val Tyr Gly Ala Pro Gly Phe Ser Lys Asp Asn Glu Ser Leu 
    370                 375                 380                 


Ile Ser Arg Ala Glu Phe Leu Ala Gly Val Arg Val Gly Val Pro Gln 
385                 390                 395                 400 


Val Ser Asp Leu Ala Ala Glu Ala Val Val Leu His Tyr Thr Asp Trp 
                405                 410                 415     


Leu His Pro Glu Asp Pro Ala Arg Leu Arg Glu Ala Leu Ser Asp Val 
            420                 425                 430         


Val Gly Asp His Asn Val Val Cys Pro Val Ala Gln Leu Ala Gly Arg 
        435                 440                 445             


Leu Ala Ala Gln Gly Ala Arg Val Tyr Ala Tyr Val Phe Glu His Arg 
    450                 455                 460                 


Ala Ser Thr Leu Ser Trp Pro Leu Trp Met Gly Val Pro His Gly Tyr 
465                 470                 475                 480 


Glu Ile Glu Phe Ile Phe Gly Ile Pro Leu Asp Pro Ser Arg Asn Tyr 
                485                 490                 495     


Thr Ala Glu Glu Lys Ile Phe Ala Gln Arg Leu Met Arg Tyr Trp Ala 
            500                 505                 510         


Asn Phe Ala Arg Thr Gly Asp Pro Asn Glu Pro Arg Asp Pro Lys Ala 
        515                 520                 525             


Pro Gln Trp Pro Pro Tyr Thr Ala Gly Ala Gln Gln Tyr Val Ser Leu 
    530                 535                 540                 


Asp Leu Arg Pro Leu Glu Val Arg Arg Gly Leu Arg Ala Gln Ala Cys 
545                 550                 555                 560 


Ala Phe Trp Asn Arg Phe Leu Pro Lys Leu Leu Ser Ala Thr Asp Thr 
                565                 570                 575     


Leu Asp Glu Ala Glu Arg Gln Trp Lys Ala Glu Phe His Arg Trp Ser 
            580                 585                 590         


Ser Tyr Met Val His Trp Lys Asn Gln Phe Asp His Tyr Ser Lys Gln 
        595                 600                 605             


Asp Arg Cys Ser Asp Leu 
    610                 


<210>  190
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  190

Met Pro Pro Ser Ile Ser Ala Phe Gln Ala Ala Tyr Ile Gly Ile Glu 
1               5                   10                  15      


Val Leu Ile Ala Leu Val Ser Val Pro Gly Asn Val Leu Val Ile Trp 
            20                  25                  30          


Ala Val Lys Val Asn Gln Ala Leu Arg Asp Ala Thr Phe Cys Phe Ile 
        35                  40                  45              


Val Ser Leu Ala Val Ala Asp Val Ala Val Gly Ala Leu Val Ile Pro 
    50                  55                  60                  


Leu Ala Ile Leu Ile Asn Ile Gly Pro Gln Thr Tyr Phe His Thr Cys 
65                  70                  75                  80  


Leu Met Val Ala Cys Pro Val Leu Ile Leu Thr Gln Ser Ser Ile Leu 
                85                  90                  95      


Ala Leu Leu Ala Ile Ala Val Asp Arg Tyr Leu Arg Val Lys Ile Pro 
            100                 105                 110         


Leu Arg Tyr Lys Met Val Val Thr Pro Arg Arg Ala Ala Val Ala Ile 
        115                 120                 125             


Ala Gly Cys Trp Ile Leu Ser Phe Val Val Gly Leu Thr Pro Met Phe 
    130                 135                 140                 


Gly Trp Asn Asn Leu Ser Ala Val Glu Arg Ala Trp Ala Ala Asn Gly 
145                 150                 155                 160 


Ser Met Gly Glu Pro Val Ile Lys Cys Glu Phe Glu Lys Val Ile Ser 
                165                 170                 175     


Met Glu Tyr Met Val Tyr Phe Asn Phe Phe Val Trp Val Leu Pro Pro 
            180                 185                 190         


Leu Leu Leu Met Val Leu Ile Tyr Leu Glu Val Phe Tyr Leu Ile Arg 
        195                 200                 205             


Lys Gln Leu Asn Lys Lys Val Ser Ala Ser Ser Gly Asp Pro Gln Lys 
    210                 215                 220                 


Tyr Tyr Gly Lys Glu Leu Lys Ile Ala Lys Ser Leu Ala Leu Ile Leu 
225                 230                 235                 240 


Phe Leu Phe Ala Leu Ser Trp Leu Pro Leu His Ile Leu Asn Cys Ile 
                245                 250                 255     


Thr Leu Phe Cys Pro Ser Cys His Lys Pro Ser Ile Leu Thr Tyr Ile 
            260                 265                 270         


Ala Ile Phe Leu Thr His Gly Asn Ser Ala Met Asn Pro Ile Val Tyr 
        275                 280                 285             


Ala Phe Arg Ile Gln Lys Phe Arg Val Thr Phe Leu Lys Ile Trp Asn 
    290                 295                 300                 


Asp His Phe Arg Cys Gln Pro Ala Pro Pro Ile Asp Glu Asp Leu Pro 
305                 310                 315                 320 


Glu Glu Arg Pro Asp Asp 
                325     


<210>  191
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  191

Met Leu Leu Glu Thr Gln Asp Ala Leu Tyr Val Ala Leu Glu Leu Val 
1               5                   10                  15      


Ile Ala Ala Leu Ser Val Ala Gly Asn Val Leu Val Cys Ala Ala Val 
            20                  25                  30          


Gly Thr Ala Asn Thr Leu Gln Thr Pro Thr Asn Tyr Phe Leu Val Ser 
        35                  40                  45              


Leu Ala Ala Ala Asp Val Ala Val Gly Leu Phe Ala Ile Pro Phe Ala 
    50                  55                  60                  


Ile Thr Ile Ser Leu Gly Phe Cys Thr Asp Phe Tyr Gly Cys Leu Phe 
65                  70                  75                  80  


Leu Ala Cys Phe Val Leu Val Leu Thr Gln Ser Ser Ile Phe Ser Leu 
                85                  90                  95      


Leu Ala Val Ala Val Asp Arg Tyr Leu Ala Ile Cys Val Pro Leu Arg 
            100                 105                 110         


Tyr Lys Ser Leu Val Thr Gly Thr Arg Ala Arg Gly Val Ile Ala Val 
        115                 120                 125             


Leu Trp Val Leu Ala Phe Gly Ile Gly Leu Thr Pro Phe Leu Gly Trp 
    130                 135                 140                 


Asn Ser Lys Asp Ser Ala Thr Asn Asn Cys Thr Glu Pro Trp Asp Gly 
145                 150                 155                 160 


Thr Thr Asn Glu Ser Cys Cys Leu Val Lys Cys Leu Phe Glu Asn Val 
                165                 170                 175     


Val Pro Met Ser Tyr Met Val Tyr Phe Asn Phe Phe Gly Cys Val Leu 
            180                 185                 190         


Pro Pro Leu Leu Ile Met Leu Val Ile Tyr Ile Lys Ile Phe Leu Val 
        195                 200                 205             


Ala Cys Arg Gln Leu Gln Arg Thr Glu Leu Met Asp His Ser Arg Thr 
    210                 215                 220                 


Thr Leu Gln Arg Glu Ile His Ala Ala Lys Ser Leu Ala Met Ile Val 
225                 230                 235                 240 


Gly Ile Phe Ala Leu Cys Trp Leu Pro Val His Ala Val Asn Cys Val 
                245                 250                 255     


Thr Leu Phe Gln Pro Ala Gln Gly Lys Asn Lys Pro Lys Trp Ala Met 
            260                 265                 270         


Asn Met Ala Ile Leu Leu Ser His Ala Asn Ser Val Val Asn Pro Ile 
        275                 280                 285             


Val Tyr Ala Tyr Arg Asn Arg Asp Phe Arg Tyr Thr Phe His Lys Ile 
    290                 295                 300                 


Ile Ser Arg Tyr Leu Leu Cys Gln Ala Asp Val Lys Ser Gly Asn Gly 
305                 310                 315                 320 


Gln Ala Gly Val Gln Pro Ala Leu Gly Val Gly Leu 
                325                 330         


<210>  192
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  192

Met Pro Asn Asn Ser Thr Ala Leu Ser Leu Ala Asn Val Thr Tyr Ile 
1               5                   10                  15      


Thr Met Glu Ile Phe Ile Gly Leu Cys Ala Ile Val Gly Asn Val Leu 
            20                  25                  30          


Val Ile Cys Val Val Lys Leu Asn Pro Ser Leu Gln Thr Thr Thr Phe 
        35                  40                  45              


Tyr Phe Ile Val Ser Leu Ala Leu Ala Asp Ile Ala Val Gly Val Leu 
    50                  55                  60                  


Val Met Pro Leu Ala Ile Val Val Ser Leu Gly Ile Thr Ile His Phe 
65                  70                  75                  80  


Tyr Ser Cys Leu Phe Met Thr Cys Leu Leu Leu Ile Phe Thr His Ala 
                85                  90                  95      


Ser Ile Met Ser Leu Leu Ala Ile Ala Val Asp Arg Tyr Leu Arg Val 
            100                 105                 110         


Lys Leu Thr Val Arg Tyr Lys Arg Val Thr Thr His Arg Arg Ile Trp 
        115                 120                 125             


Leu Ala Leu Gly Leu Cys Trp Leu Val Ser Phe Leu Val Gly Leu Thr 
    130                 135                 140                 


Pro Met Phe Gly Trp Asn Met Lys Leu Thr Ser Glu Tyr His Arg Asn 
145                 150                 155                 160 


Val Thr Phe Leu Ser Cys Gln Phe Val Ser Val Met Arg Met Asp Tyr 
                165                 170                 175     


Met Val Tyr Phe Ser Phe Leu Thr Trp Ile Phe Ile Pro Leu Val Val 
            180                 185                 190         


Met Cys Ala Ile Tyr Leu Asp Ile Phe Tyr Ile Ile Arg Asn Lys Leu 
        195                 200                 205             


Ser Leu Asn Leu Ser Asn Ser Lys Glu Thr Gly Ala Phe Tyr Gly Arg 
    210                 215                 220                 


Glu Phe Lys Thr Ala Lys Ser Leu Phe Leu Val Leu Phe Leu Phe Ala 
225                 230                 235                 240 


Leu Ser Trp Leu Pro Leu Ser Ile Ile Asn Cys Ile Ile Tyr Phe Asn 
                245                 250                 255     


Gly Glu Val Pro Gln Leu Val Leu Tyr Met Gly Ile Leu Leu Ser His 
            260                 265                 270         


Ala Asn Ser Met Met Asn Pro Ile Val Tyr Ala Tyr Lys Ile Lys Lys 
        275                 280                 285             


Phe Lys Glu Thr Tyr Leu Leu Ile Leu Lys Ala Cys Val Val Cys His 
    290                 295                 300                 


Pro Ser Asp Ser Leu Asp Thr Ser Ile Glu Lys Asn Ser Glu 
305                 310                 315             


<210>  193
<211>  572
<212>  PRT
<213>  Homo sapiens

<400>  193

Met Thr Phe Arg Asp Leu Leu Ser Val Ser Phe Glu Gly Pro Arg Pro 
1               5                   10                  15      


Asp Ser Ser Ala Gly Gly Ser Ser Ala Gly Gly Gly Gly Gly Ser Ala 
            20                  25                  30          


Gly Gly Ala Ala Pro Ser Glu Gly Pro Ala Val Gly Gly Val Pro Gly 
        35                  40                  45              


Gly Ala Gly Gly Gly Gly Gly Val Val Gly Ala Gly Ser Gly Glu Asp 
    50                  55                  60                  


Asn Arg Ser Ser Ala Gly Glu Pro Gly Ser Ala Gly Ala Gly Gly Asp 
65                  70                  75                  80  


Val Asn Gly Thr Ala Ala Val Gly Gly Leu Val Val Ser Ala Gln Gly 
                85                  90                  95      


Val Gly Val Gly Val Phe Leu Ala Ala Phe Ile Leu Met Ala Val Ala 
            100                 105                 110         


Gly Asn Leu Leu Val Ile Leu Ser Val Ala Cys Asn Arg His Leu Gln 
        115                 120                 125             


Thr Val Thr Asn Tyr Phe Ile Val Asn Leu Ala Val Ala Asp Leu Leu 
    130                 135                 140                 


Leu Ser Ala Thr Val Leu Pro Phe Ser Ala Thr Met Glu Val Leu Gly 
145                 150                 155                 160 


Phe Trp Ala Phe Gly Arg Ala Phe Cys Asp Val Trp Ala Ala Val Asp 
                165                 170                 175     


Val Leu Cys Cys Thr Ala Ser Ile Leu Ser Leu Cys Thr Ile Ser Val 
            180                 185                 190         


Asp Arg Tyr Val Gly Val Arg His Ser Leu Lys Tyr Pro Ala Ile Met 
        195                 200                 205             


Thr Glu Arg Lys Ala Ala Ala Ile Leu Ala Leu Leu Trp Val Val Ala 
    210                 215                 220                 


Leu Val Val Ser Val Gly Pro Leu Leu Gly Trp Lys Glu Pro Val Pro 
225                 230                 235                 240 


Pro Asp Glu Arg Phe Cys Gly Ile Thr Glu Glu Ala Gly Tyr Ala Val 
                245                 250                 255     


Phe Ser Ser Val Cys Ser Phe Tyr Leu Pro Met Ala Val Ile Val Val 
            260                 265                 270         


Met Tyr Cys Arg Val Tyr Val Val Ala Arg Ser Thr Thr Arg Ser Leu 
        275                 280                 285             


Glu Ala Gly Val Lys Arg Glu Arg Gly Lys Ala Ser Glu Val Val Leu 
    290                 295                 300                 


Arg Ile His Cys Arg Gly Ala Ala Thr Gly Ala Asp Gly Ala His Gly 
305                 310                 315                 320 


Met Arg Ser Ala Lys Gly His Thr Phe Arg Ser Ser Leu Ser Val Arg 
                325                 330                 335     


Leu Leu Lys Phe Ser Arg Glu Lys Lys Ala Ala Lys Thr Leu Ala Ile 
            340                 345                 350         


Val Val Gly Val Phe Val Leu Cys Trp Phe Pro Phe Phe Phe Val Leu 
        355                 360                 365             


Pro Leu Gly Ser Leu Phe Pro Gln Leu Lys Pro Ser Glu Gly Val Phe 
    370                 375                 380                 


Lys Val Ile Phe Trp Leu Gly Tyr Phe Asn Ser Cys Val Asn Pro Leu 
385                 390                 395                 400 


Ile Tyr Pro Cys Ser Ser Arg Glu Phe Lys Arg Ala Phe Leu Arg Leu 
                405                 410                 415     


Leu Arg Cys Gln Cys Arg Arg Arg Arg Arg Arg Arg Pro Leu Trp Arg 
            420                 425                 430         


Val Tyr Gly His His Trp Arg Ala Ser Thr Ser Gly Leu Arg Gln Asp 
        435                 440                 445             


Cys Ala Pro Ser Ser Gly Asp Ala Pro Pro Gly Ala Pro Leu Ala Leu 
    450                 455                 460                 


Thr Ala Leu Pro Asp Pro Asp Pro Glu Pro Pro Gly Thr Pro Glu Met 
465                 470                 475                 480 


Gln Ala Pro Val Ala Ser Arg Arg Lys Pro Pro Ser Ala Phe Arg Glu 
                485                 490                 495     


Trp Arg Leu Leu Gly Pro Phe Arg Arg Pro Thr Thr Gln Leu Arg Ala 
            500                 505                 510         


Lys Val Ser Ser Leu Ser His Lys Ile Arg Ala Gly Gly Ala Gln Arg 
        515                 520                 525             


Ala Glu Ala Ala Cys Ala Gln Arg Ser Glu Val Glu Ala Val Ser Leu 
    530                 535                 540                 


Gly Val Pro His Glu Val Ala Glu Gly Ala Thr Cys Gln Ala Tyr Glu 
545                 550                 555                 560 


Leu Ala Asp Tyr Ser Asn Leu Arg Glu Thr Asp Ile 
                565                 570         


<210>  194
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  194

Met Asn Pro Asp Leu Asp Thr Gly His Asn Thr Ser Ala Pro Ala His 
1               5                   10                  15      


Trp Gly Glu Leu Lys Asn Ala Asn Phe Thr Gly Pro Asn Gln Thr Ser 
            20                  25                  30          


Ser Asn Ser Thr Leu Pro Gln Leu Asp Ile Thr Arg Ala Ile Ser Val 
        35                  40                  45              


Gly Leu Val Leu Gly Ala Phe Ile Leu Phe Ala Ile Val Gly Asn Ile 
    50                  55                  60                  


Leu Val Ile Leu Ser Val Ala Cys Asn Arg His Leu Arg Thr Pro Thr 
65                  70                  75                  80  


Asn Tyr Phe Ile Val Asn Leu Ala Met Ala Asp Leu Leu Leu Ser Phe 
                85                  90                  95      


Thr Val Leu Pro Phe Ser Ala Ala Leu Glu Val Leu Gly Tyr Trp Val 
            100                 105                 110         


Leu Gly Arg Ile Phe Cys Asp Ile Trp Ala Ala Val Asp Val Leu Cys 
        115                 120                 125             


Cys Thr Ala Ser Ile Leu Ser Leu Cys Ala Ile Ser Ile Asp Arg Tyr 
    130                 135                 140                 


Ile Gly Val Arg Tyr Ser Leu Gln Tyr Pro Thr Leu Val Thr Arg Arg 
145                 150                 155                 160 


Lys Ala Ile Leu Ala Leu Leu Ser Val Trp Val Leu Ser Thr Val Ile 
                165                 170                 175     


Ser Ile Gly Pro Leu Leu Gly Trp Lys Glu Pro Ala Pro Asn Asp Asp 
            180                 185                 190         


Lys Glu Cys Gly Val Thr Glu Glu Pro Phe Tyr Ala Leu Phe Ser Ser 
        195                 200                 205             


Leu Gly Ser Phe Tyr Ile Pro Leu Ala Val Ile Leu Val Met Tyr Cys 
    210                 215                 220                 


Arg Val Tyr Ile Val Ala Lys Arg Thr Thr Lys Asn Leu Glu Ala Gly 
225                 230                 235                 240 


Val Met Lys Glu Met Ser Asn Ser Lys Glu Leu Thr Leu Arg Ile His 
                245                 250                 255     


Ser Lys Asn Phe His Glu Asp Thr Leu Ser Ser Thr Lys Ala Lys Gly 
            260                 265                 270         


His Asn Pro Arg Ser Ser Ile Ala Val Lys Leu Phe Lys Phe Ser Arg 
        275                 280                 285             


Glu Lys Lys Ala Ala Lys Thr Leu Gly Ile Val Val Gly Met Phe Ile 
    290                 295                 300                 


Leu Cys Trp Leu Pro Phe Phe Ile Ala Leu Pro Leu Gly Ser Leu Phe 
305                 310                 315                 320 


Ser Thr Leu Lys Pro Pro Asp Ala Val Phe Lys Val Val Phe Trp Leu 
                325                 330                 335     


Gly Tyr Phe Asn Ser Cys Leu Asn Pro Ile Ile Tyr Pro Cys Ser Ser 
            340                 345                 350         


Lys Glu Phe Lys Arg Ala Phe Val Arg Ile Leu Gly Cys Gln Cys Arg 
        355                 360                 365             


Gly Arg Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Leu Gly Gly Cys 
    370                 375                 380                 


Ala Tyr Thr Tyr Arg Pro Trp Thr Arg Gly Gly Ser Leu Glu Arg Ser 
385                 390                 395                 400 


Gln Ser Arg Lys Asp Ser Leu Asp Asp Ser Gly Ser Cys Leu Ser Gly 
                405                 410                 415     


Ser Gln Arg Thr Leu Pro Ser Ala Ser Pro Ser Pro Gly Tyr Leu Gly 
            420                 425                 430         


Arg Gly Ala Pro Pro Pro Val Glu Leu Cys Ala Phe Pro Glu Trp Lys 
        435                 440                 445             


Ala Pro Gly Ala Leu Leu Ser Leu Pro Ala Pro Glu Pro Pro Gly Arg 
    450                 455                 460                 


Arg Gly Arg His Asp Ser Gly Pro Leu Phe Thr Phe Lys Leu Leu Thr 
465                 470                 475                 480 


Glu Pro Glu Ser Pro Gly Thr Asp Gly Gly Ala Ser Asn Gly Gly Cys 
                485                 490                 495     


Glu Ala Ala Ala Asp Val Ala Asn Gly Gln Pro Gly Phe Lys Ser Asn 
            500                 505                 510         


Met Pro Leu Ala Pro Gly Gln Phe 
        515                 520 


<210>  195
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  195

Met Val Phe Leu Ser Gly Asn Ala Ser Asp Ser Ser Asn Cys Thr Gln 
1               5                   10                  15      


Pro Pro Ala Pro Val Asn Ile Ser Lys Ala Ile Leu Leu Gly Val Ile 
            20                  25                  30          


Leu Gly Gly Leu Ile Leu Phe Gly Val Leu Gly Asn Ile Leu Val Ile 
        35                  40                  45              


Leu Ser Val Ala Cys His Arg His Leu His Ser Val Thr His Tyr Tyr 
    50                  55                  60                  


Ile Val Asn Leu Ala Val Ala Asp Leu Leu Leu Thr Ser Thr Val Leu 
65                  70                  75                  80  


Pro Phe Ser Ala Ile Phe Glu Val Leu Gly Tyr Trp Ala Phe Gly Arg 
                85                  90                  95      


Val Phe Cys Asn Ile Trp Ala Ala Val Asp Val Leu Cys Cys Thr Ala 
            100                 105                 110         


Ser Ile Met Gly Leu Cys Ile Ile Ser Ile Asp Arg Tyr Ile Gly Val 
        115                 120                 125             


Ser Tyr Pro Leu Arg Tyr Pro Thr Ile Val Thr Gln Arg Arg Gly Leu 
    130                 135                 140                 


Met Ala Leu Leu Cys Val Trp Ala Leu Ser Leu Val Ile Ser Ile Gly 
145                 150                 155                 160 


Pro Leu Phe Gly Trp Arg Gln Pro Ala Pro Glu Asp Glu Thr Ile Cys 
                165                 170                 175     


Gln Ile Asn Glu Glu Pro Gly Tyr Val Leu Phe Ser Ala Leu Gly Ser 
            180                 185                 190         


Phe Tyr Leu Pro Leu Ala Ile Ile Leu Val Met Tyr Cys Arg Val Tyr 
        195                 200                 205             


Val Val Ala Lys Arg Glu Ser Arg Gly Leu Lys Ser Gly Leu Lys Thr 
    210                 215                 220                 


Asp Lys Ser Asp Ser Glu Gln Val Thr Leu Arg Ile His Arg Lys Asn 
225                 230                 235                 240 


Ala Pro Ala Gly Gly Ser Gly Met Ala Ser Ala Lys Thr Lys Thr His 
                245                 250                 255     


Phe Ser Val Arg Leu Leu Lys Phe Ser Arg Glu Lys Lys Ala Ala Lys 
            260                 265                 270         


Thr Leu Gly Ile Val Val Gly Cys Phe Val Leu Cys Trp Leu Pro Phe 
        275                 280                 285             


Phe Leu Val Met Pro Ile Gly Ser Phe Phe Pro Asp Phe Lys Pro Ser 
    290                 295                 300                 


Glu Thr Val Phe Lys Ile Val Phe Trp Leu Gly Tyr Leu Asn Ser Cys 
305                 310                 315                 320 


Ile Asn Pro Ile Ile Tyr Pro Cys Ser Ser Gln Glu Phe Lys Lys Ala 
                325                 330                 335     


Phe Gln Asn Val Leu Arg Ile Gln Cys Leu Cys Arg Lys Gln Ser Ser 
            340                 345                 350         


Lys His Ala Leu Gly Tyr Thr Leu His Pro Pro Ser Gln Ala Val Glu 
        355                 360                 365             


Gly Gln His Lys Asp Met Val Arg Ile Pro Val Gly Ser Arg Glu Thr 
    370                 375                 380                 


Phe Tyr Arg Ile Ser Lys Thr Asp Gly Val Cys Glu Trp Lys Phe Phe 
385                 390                 395                 400 


Ser Ser Met Pro Arg Gly Ser Ala Arg Ile Thr Val Ser Lys Asp Gln 
                405                 410                 415     


Ser Ser Cys Thr Thr Ala Arg Val Arg Ser Lys Ser Phe Leu Gln Val 
            420                 425                 430         


Cys Cys Cys Val Gly Pro Ser Thr Pro Ser Leu Asp Lys Asn His Gln 
        435                 440                 445             


Val Pro Thr Ile Lys Val His Thr Ile Ser Leu Ser Glu Asn Gly Glu 
    450                 455                 460                 


Glu Val 
465     


<210>  196
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  196

Met Phe Arg Gln Glu Gln Pro Leu Ala Glu Gly Ser Phe Ala Pro Met 
1               5                   10                  15      


Gly Ser Leu Gln Pro Asp Ala Gly Asn Ala Ser Trp Asn Gly Thr Glu 
            20                  25                  30          


Ala Pro Gly Gly Gly Ala Arg Ala Thr Pro Tyr Ser Leu Gln Val Thr 
        35                  40                  45              


Leu Thr Leu Val Cys Leu Ala Gly Leu Leu Met Leu Leu Thr Val Phe 
    50                  55                  60                  


Gly Asn Val Leu Val Ile Ile Ala Val Phe Thr Ser Arg Ala Leu Lys 
65                  70                  75                  80  


Ala Pro Gln Asn Leu Phe Leu Val Ser Leu Ala Ser Ala Asp Ile Leu 
                85                  90                  95      


Val Ala Thr Leu Val Ile Pro Phe Ser Leu Ala Asn Glu Val Met Gly 
            100                 105                 110         


Tyr Trp Tyr Phe Gly Lys Ala Trp Cys Glu Ile Tyr Leu Ala Leu Asp 
        115                 120                 125             


Val Leu Phe Cys Thr Ser Ser Ile Val His Leu Cys Ala Ile Ser Leu 
    130                 135                 140                 


Asp Arg Tyr Trp Ser Ile Thr Gln Ala Ile Glu Tyr Asn Leu Lys Arg 
145                 150                 155                 160 


Thr Pro Arg Arg Ile Lys Ala Ile Ile Ile Thr Val Trp Val Ile Ser 
                165                 170                 175     


Ala Val Ile Ser Phe Pro Pro Leu Ile Ser Ile Glu Lys Lys Gly Gly 
            180                 185                 190         


Gly Gly Gly Pro Gln Pro Ala Glu Pro Arg Cys Glu Ile Asn Asp Gln 
        195                 200                 205             


Lys Trp Tyr Val Ile Ser Ser Cys Ile Gly Ser Phe Phe Ala Pro Cys 
    210                 215                 220                 


Leu Ile Met Ile Leu Val Tyr Val Arg Ile Tyr Gln Ile Ala Lys Arg 
225                 230                 235                 240 


Arg Thr Arg Val Pro Pro Ser Arg Arg Gly Pro Asp Ala Val Ala Ala 
                245                 250                 255     


Pro Pro Gly Gly Thr Glu Arg Arg Pro Asn Gly Leu Gly Pro Glu Arg 
            260                 265                 270         


Ser Ala Gly Pro Gly Gly Ala Glu Ala Glu Pro Leu Pro Thr Gln Leu 
        275                 280                 285             


Asn Gly Ala Pro Gly Glu Pro Ala Pro Ala Gly Pro Arg Asp Thr Asp 
    290                 295                 300                 


Ala Leu Asp Leu Glu Glu Ser Ser Ser Ser Asp His Ala Glu Arg Pro 
305                 310                 315                 320 


Pro Gly Pro Arg Arg Pro Glu Arg Gly Pro Arg Gly Lys Gly Lys Ala 
                325                 330                 335     


Arg Ala Ser Gln Val Lys Pro Gly Asp Ser Leu Pro Arg Arg Gly Pro 
            340                 345                 350         


Gly Ala Thr Gly Ile Gly Thr Pro Ala Ala Gly Pro Gly Glu Glu Arg 
        355                 360                 365             


Val Gly Ala Ala Lys Ala Ser Arg Trp Arg Gly Arg Gln Asn Arg Glu 
    370                 375                 380                 


Lys Arg Phe Thr Phe Val Leu Ala Val Val Ile Gly Val Phe Val Val 
385                 390                 395                 400 


Cys Trp Phe Pro Phe Phe Phe Thr Tyr Thr Leu Thr Ala Val Gly Cys 
                405                 410                 415     


Ser Val Pro Arg Thr Leu Phe Lys Phe Phe Phe Trp Phe Gly Tyr Cys 
            420                 425                 430         


Asn Ser Ser Leu Asn Pro Val Ile Tyr Thr Ile Phe Asn His Asp Phe 
        435                 440                 445             


Arg Arg Ala Phe Lys Lys Ile Leu Cys Arg Gly Asp Arg Lys Arg Ile 
    450                 455                 460                 


Val 
465 


<210>  197
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  197

Met Asp His Gln Asp Pro Tyr Ser Val Gln Ala Thr Ala Ala Ile Ala 
1               5                   10                  15      


Ala Ala Ile Thr Phe Leu Ile Leu Phe Thr Ile Phe Gly Asn Ala Leu 
            20                  25                  30          


Val Ile Leu Ala Val Leu Thr Ser Arg Ser Leu Arg Ala Pro Gln Asn 
        35                  40                  45              


Leu Phe Leu Val Ser Leu Ala Ala Ala Asp Ile Leu Val Ala Thr Leu 
    50                  55                  60                  


Ile Ile Pro Phe Ser Leu Ala Asn Glu Leu Leu Gly Tyr Trp Tyr Phe 
65                  70                  75                  80  


Arg Arg Thr Trp Cys Glu Val Tyr Leu Ala Leu Asp Val Leu Phe Cys 
                85                  90                  95      


Thr Ser Ser Ile Val His Leu Cys Ala Ile Ser Leu Asp Arg Tyr Trp 
            100                 105                 110         


Ala Val Ser Arg Ala Leu Glu Tyr Asn Ser Lys Arg Thr Pro Arg Arg 
        115                 120                 125             


Ile Lys Cys Ile Ile Leu Thr Val Trp Leu Ile Ala Ala Val Ile Ser 
    130                 135                 140                 


Leu Pro Pro Leu Ile Tyr Lys Gly Asp Gln Gly Pro Gln Pro Arg Gly 
145                 150                 155                 160 


Arg Pro Gln Cys Lys Leu Asn Gln Glu Ala Trp Tyr Ile Leu Ala Ser 
                165                 170                 175     


Ser Ile Gly Ser Phe Phe Ala Pro Cys Leu Ile Met Ile Leu Val Tyr 
            180                 185                 190         


Leu Arg Ile Tyr Leu Ile Ala Lys Arg Ser Asn Arg Arg Gly Pro Arg 
        195                 200                 205             


Ala Lys Gly Gly Pro Gly Gln Gly Glu Ser Lys Gln Pro Arg Pro Asp 
    210                 215                 220                 


His Gly Gly Ala Leu Ala Ser Ala Lys Leu Pro Ala Leu Ala Ser Val 
225                 230                 235                 240 


Ala Ser Ala Arg Glu Val Asn Gly His Ser Lys Ser Thr Gly Glu Lys 
                245                 250                 255     


Glu Glu Gly Glu Thr Pro Glu Asp Thr Gly Thr Arg Ala Leu Pro Pro 
            260                 265                 270         


Ser Trp Ala Ala Leu Pro Asn Ser Gly Gln Gly Gln Lys Glu Gly Val 
        275                 280                 285             


Cys Gly Ala Ser Pro Glu Asp Glu Ala Glu Glu Glu Glu Glu Glu Glu 
    290                 295                 300                 


Glu Glu Glu Glu Glu Cys Glu Pro Gln Ala Val Pro Val Ser Pro Ala 
305                 310                 315                 320 


Ser Ala Cys Ser Pro Pro Leu Gln Gln Pro Gln Gly Ser Arg Val Leu 
                325                 330                 335     


Ala Thr Leu Arg Gly Gln Val Leu Leu Gly Arg Gly Val Gly Ala Ile 
            340                 345                 350         


Gly Gly Gln Trp Trp Arg Arg Arg Ala Gln Leu Thr Arg Glu Lys Arg 
        355                 360                 365             


Phe Thr Phe Val Leu Ala Val Val Ile Gly Val Phe Val Leu Cys Trp 
    370                 375                 380                 


Phe Pro Phe Phe Phe Ser Tyr Ser Leu Gly Ala Ile Cys Pro Lys His 
385                 390                 395                 400 


Cys Lys Val Pro His Gly Leu Phe Gln Phe Phe Phe Trp Ile Gly Tyr 
                405                 410                 415     


Cys Asn Ser Ser Leu Asn Pro Val Ile Tyr Thr Ile Phe Asn Gln Asp 
            420                 425                 430         


Phe Arg Arg Ala Phe Arg Arg Ile Leu Cys Arg Pro Trp Thr Gln Thr 
        435                 440                 445             


Ala Trp 
    450 


<210>  198
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  198

Met Ala Ser Pro Ala Leu Ala Ala Ala Leu Ala Val Ala Ala Ala Ala 
1               5                   10                  15      


Gly Pro Asn Ala Ser Gly Ala Gly Glu Arg Gly Ser Gly Gly Val Ala 
            20                  25                  30          


Asn Ala Ser Gly Ala Ser Trp Gly Pro Pro Arg Gly Gln Tyr Ser Ala 
        35                  40                  45              


Gly Ala Val Ala Gly Leu Ala Ala Val Val Gly Phe Leu Ile Val Phe 
    50                  55                  60                  


Thr Val Val Gly Asn Val Leu Val Val Ile Ala Val Leu Thr Ser Arg 
65                  70                  75                  80  


Ala Leu Arg Ala Pro Gln Asn Leu Phe Leu Val Ser Leu Ala Ser Ala 
                85                  90                  95      


Asp Ile Leu Val Ala Thr Leu Val Met Pro Phe Ser Leu Ala Asn Glu 
            100                 105                 110         


Leu Met Ala Tyr Trp Tyr Phe Gly Gln Val Trp Cys Gly Val Tyr Leu 
        115                 120                 125             


Ala Leu Asp Val Leu Phe Cys Thr Ser Ser Ile Val His Leu Cys Ala 
    130                 135                 140                 


Ile Ser Leu Asp Arg Tyr Trp Ser Val Thr Gln Ala Val Glu Tyr Asn 
145                 150                 155                 160 


Leu Lys Arg Thr Pro Arg Arg Val Lys Ala Thr Ile Val Ala Val Trp 
                165                 170                 175     


Leu Ile Ser Ala Val Ile Ser Phe Pro Pro Leu Val Ser Leu Tyr Arg 
            180                 185                 190         


Gln Pro Asp Gly Ala Ala Tyr Pro Gln Cys Gly Leu Asn Asp Glu Thr 
        195                 200                 205             


Trp Tyr Ile Leu Ser Ser Cys Ile Gly Ser Phe Phe Ala Pro Cys Leu 
    210                 215                 220                 


Ile Met Gly Leu Val Tyr Ala Arg Ile Tyr Arg Val Ala Lys Leu Arg 
225                 230                 235                 240 


Thr Arg Thr Leu Ser Glu Lys Arg Ala Pro Val Gly Pro Asp Gly Ala 
                245                 250                 255     


Ser Pro Thr Thr Glu Asn Gly Leu Gly Ala Ala Ala Gly Ala Gly Glu 
            260                 265                 270         


Asn Gly His Cys Ala Pro Pro Pro Ala Asp Val Glu Pro Asp Glu Ser 
        275                 280                 285             


Ser Ala Ala Ala Glu Arg Arg Arg Arg Arg Gly Ala Leu Arg Arg Gly 
    290                 295                 300                 


Gly Arg Arg Arg Ala Gly Ala Glu Gly Gly Ala Gly Gly Ala Asp Gly 
305                 310                 315                 320 


Gln Gly Ala Gly Pro Gly Ala Ala Glu Ser Gly Ala Leu Thr Ala Ser 
                325                 330                 335     


Arg Ser Pro Gly Pro Gly Gly Arg Leu Ser Arg Ala Ser Ser Arg Ser 
            340                 345                 350         


Val Glu Phe Phe Leu Ser Arg Arg Arg Arg Ala Arg Ser Ser Val Cys 
        355                 360                 365             


Arg Arg Lys Val Ala Gln Ala Arg Glu Lys Arg Phe Thr Phe Val Leu 
    370                 375                 380                 


Ala Val Val Met Gly Val Phe Val Leu Cys Trp Phe Pro Phe Phe Phe 
385                 390                 395                 400 


Ser Tyr Ser Leu Tyr Gly Ile Cys Arg Glu Ala Cys Gln Val Pro Gly 
                405                 410                 415     


Pro Leu Phe Lys Phe Phe Phe Trp Ile Gly Tyr Cys Asn Ser Ser Leu 
            420                 425                 430         


Asn Pro Val Ile Tyr Thr Val Phe Asn Gln Asp Phe Arg Arg Ser Phe 
        435                 440                 445             


Lys His Ile Leu Phe Arg Arg Arg Arg Arg Gly Phe Arg Gln 
    450                 455                 460         


<210>  199
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  199

Met Gly Ala Gly Val Leu Val Leu Gly Ala Ser Glu Pro Gly Asn Leu 
1               5                   10                  15      


Ser Ser Ala Ala Pro Leu Pro Asp Gly Ala Ala Thr Ala Ala Arg Leu 
            20                  25                  30          


Leu Val Pro Ala Ser Pro Pro Ala Ser Leu Leu Pro Pro Ala Ser Glu 
        35                  40                  45              


Ser Pro Glu Pro Leu Ser Gln Gln Trp Thr Ala Gly Met Gly Leu Leu 
    50                  55                  60                  


Met Ala Leu Ile Val Leu Leu Ile Val Ala Gly Asn Val Leu Val Ile 
65                  70                  75                  80  


Val Ala Ile Ala Lys Thr Pro Arg Leu Gln Thr Leu Thr Asn Leu Phe 
                85                  90                  95      


Ile Met Ser Leu Ala Ser Ala Asp Leu Val Met Gly Leu Leu Val Val 
            100                 105                 110         


Pro Phe Gly Ala Thr Ile Val Val Trp Gly Arg Trp Glu Tyr Gly Ser 
        115                 120                 125             


Phe Phe Cys Glu Leu Trp Thr Ser Val Asp Val Leu Cys Val Thr Ala 
    130                 135                 140                 


Ser Ile Glu Thr Leu Cys Val Ile Ala Leu Asp Arg Tyr Leu Ala Ile 
145                 150                 155                 160 


Thr Ser Pro Phe Arg Tyr Gln Ser Leu Leu Thr Arg Ala Arg Ala Arg 
                165                 170                 175     


Gly Leu Val Cys Thr Val Trp Ala Ile Ser Ala Leu Val Ser Phe Leu 
            180                 185                 190         


Pro Ile Leu Met His Trp Trp Arg Ala Glu Ser Asp Glu Ala Arg Arg 
        195                 200                 205             


Cys Tyr Asn Asp Pro Lys Cys Cys Asp Phe Val Thr Asn Arg Ala Tyr 
    210                 215                 220                 


Ala Ile Ala Ser Ser Val Val Ser Phe Tyr Val Pro Leu Cys Ile Met 
225                 230                 235                 240 


Ala Phe Val Tyr Leu Arg Val Phe Arg Glu Ala Gln Lys Gln Val Lys 
                245                 250                 255     


Lys Ile Asp Ser Cys Glu Arg Arg Phe Leu Gly Gly Pro Ala Arg Pro 
            260                 265                 270         


Pro Ser Pro Ser Pro Ser Pro Val Pro Ala Pro Ala Pro Pro Pro Gly 
        275                 280                 285             


Pro Pro Arg Pro Ala Ala Ala Ala Ala Thr Ala Pro Leu Ala Asn Gly 
    290                 295                 300                 


Arg Ala Gly Lys Arg Arg Pro Ser Arg Leu Val Ala Leu Arg Glu Gln 
305                 310                 315                 320 


Lys Ala Leu Lys Thr Leu Gly Ile Ile Met Gly Val Phe Thr Leu Cys 
                325                 330                 335     


Trp Leu Pro Phe Phe Leu Ala Asn Val Val Lys Ala Phe His Arg Glu 
            340                 345                 350         


Leu Val Pro Asp Arg Leu Phe Val Phe Phe Asn Trp Leu Gly Tyr Ala 
        355                 360                 365             


Asn Ser Ala Phe Asn Pro Ile Ile Tyr Cys Arg Ser Pro Asp Phe Arg 
    370                 375                 380                 


Lys Ala Phe Gln Gly Leu Leu Cys Cys Ala Arg Arg Ala Ala Arg Arg 
385                 390                 395                 400 


Arg His Ala Thr His Gly Asp Arg Pro Arg Ala Ser Gly Cys Leu Ala 
                405                 410                 415     


Arg Pro Gly Pro Pro Pro Ser Pro Gly Ala Ala Ser Asp Asp Asp Asp 
            420                 425                 430         


Asp Asp Val Val Gly Ala Thr Pro Pro Ala Arg Leu Leu Glu Pro Trp 
        435                 440                 445             


Ala Gly Cys Asn Gly Gly Ala Ala Ala Asp Ser Asp Ser Ser Leu Asp 
    450                 455                 460                 


Glu Pro Cys Arg Pro Gly Phe Ala Ser Glu Ser Lys Val 
465                 470                 475         


<210>  200
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  200

Met Ile Leu Asn Ser Ser Thr Glu Asp Gly Ile Lys Arg Ile Gln Asp 
1               5                   10                  15      


Asp Cys Pro Lys Ala Gly Arg His Asn Tyr Ile Phe Val Met Ile Pro 
            20                  25                  30          


Thr Leu Tyr Ser Ile Ile Phe Val Val Gly Ile Phe Gly Asn Ser Leu 
        35                  40                  45              


Val Val Ile Val Ile Tyr Phe Tyr Met Lys Leu Lys Thr Val Ala Ser 
    50                  55                  60                  


Val Phe Leu Leu Asn Leu Ala Leu Ala Asp Leu Cys Phe Leu Leu Thr 
65                  70                  75                  80  


Leu Pro Leu Trp Ala Val Tyr Thr Ala Met Glu Tyr Arg Trp Pro Phe 
                85                  90                  95      


Gly Asn Tyr Leu Cys Lys Ile Ala Ser Ala Ser Val Ser Phe Asn Leu 
            100                 105                 110         


Tyr Ala Ser Val Phe Leu Leu Thr Cys Leu Ser Ile Asp Arg Tyr Leu 
        115                 120                 125             


Ala Ile Val His Pro Met Lys Ser Arg Leu Arg Arg Thr Met Leu Val 
    130                 135                 140                 


Ala Lys Val Thr Cys Ile Ile Ile Trp Leu Leu Ala Gly Leu Ala Ser 
145                 150                 155                 160 


Leu Pro Ala Ile Ile His Arg Asn Val Phe Phe Ile Glu Asn Thr Asn 
                165                 170                 175     


Ile Thr Val Cys Ala Phe His Tyr Glu Ser Gln Asn Ser Thr Leu Pro 
            180                 185                 190         


Ile Gly Leu Gly Leu Thr Lys Asn Ile Leu Gly Phe Leu Phe Pro Phe 
        195                 200                 205             


Leu Ile Ile Leu Thr Ser Tyr Thr Leu Ile Trp Lys Ala Leu Lys Lys 
    210                 215                 220                 


Ala Tyr Glu Ile Gln Lys Asn Lys Pro Arg Asn Asp Asp Ile Phe Lys 
225                 230                 235                 240 


Ile Ile Met Ala Ile Val Leu Phe Phe Phe Phe Ser Trp Ile Pro His 
                245                 250                 255     


Gln Ile Phe Thr Phe Leu Asp Val Leu Ile Gln Leu Gly Ile Ile Arg 
            260                 265                 270         


Asp Cys Arg Ile Ala Asp Ile Val Asp Thr Ala Met Pro Ile Thr Ile 
        275                 280                 285             


Cys Ile Ala Tyr Phe Asn Asn Cys Leu Asn Pro Leu Phe Tyr Gly Phe 
    290                 295                 300                 


Leu Gly Lys Lys Phe Lys Arg Tyr Phe Leu Gln Leu Leu Lys Tyr Ile 
305                 310                 315                 320 


Pro Pro Lys Ala Lys Ser His Ser Asn Leu Ser Thr Lys Met Ser Thr 
                325                 330                 335     


Leu Ser Tyr Arg Pro Ser Asp Asn Val Ser Ser Ser Thr Lys Lys Pro 
            340                 345                 350         


Ala Pro Cys Phe Glu Val Glu 
        355                 


<210>  201
<211>  363
<212>  PRT
<213>  Homo sapiens

<400>  201

Met Lys Gly Asn Ser Thr Leu Ala Thr Thr Ser Lys Asn Ile Thr Ser 
1               5                   10                  15      


Gly Leu His Phe Gly Leu Val Asn Ile Ser Gly Asn Asn Glu Ser Thr 
            20                  25                  30          


Leu Asn Cys Ser Gln Lys Pro Ser Asp Lys His Leu Asp Ala Ile Pro 
        35                  40                  45              


Ile Leu Tyr Tyr Ile Ile Phe Val Ile Gly Phe Leu Val Asn Ile Val 
    50                  55                  60                  


Val Val Thr Leu Phe Cys Cys Gln Lys Gly Pro Lys Lys Val Ser Ser 
65                  70                  75                  80  


Ile Tyr Ile Phe Asn Leu Ala Val Ala Asp Leu Leu Leu Leu Ala Thr 
                85                  90                  95      


Leu Pro Leu Trp Ala Thr Tyr Tyr Ser Tyr Arg Tyr Asp Trp Leu Phe 
            100                 105                 110         


Gly Pro Val Met Cys Lys Val Phe Gly Ser Phe Leu Thr Leu Asn Met 
        115                 120                 125             


Phe Ala Ser Ile Phe Phe Ile Thr Cys Met Ser Val Asp Arg Tyr Gln 
    130                 135                 140                 


Ser Val Ile Tyr Pro Phe Leu Ser Gln Arg Arg Asn Pro Trp Gln Ala 
145                 150                 155                 160 


Ser Tyr Ile Val Pro Leu Val Trp Cys Met Ala Cys Leu Ser Ser Leu 
                165                 170                 175     


Pro Thr Phe Tyr Phe Arg Asp Val Arg Thr Ile Glu Tyr Leu Gly Val 
            180                 185                 190         


Asn Ala Cys Ile Met Ala Phe Pro Pro Glu Lys Tyr Ala Gln Trp Ser 
        195                 200                 205             


Ala Gly Ile Ala Leu Met Lys Asn Ile Leu Gly Phe Ile Ile Pro Leu 
    210                 215                 220                 


Ile Phe Ile Ala Thr Cys Tyr Phe Gly Ile Arg Lys His Leu Leu Lys 
225                 230                 235                 240 


Thr Asn Ser Tyr Gly Lys Asn Arg Ile Thr Arg Asp Gln Val Leu Lys 
                245                 250                 255     


Met Ala Ala Ala Val Val Leu Ala Phe Ile Ile Cys Trp Leu Pro Phe 
            260                 265                 270         


His Val Leu Thr Phe Leu Asp Ala Leu Ala Trp Met Gly Val Ile Asn 
        275                 280                 285             


Ser Cys Glu Val Ile Ala Val Ile Asp Leu Ala Leu Pro Phe Ala Ile 
    290                 295                 300                 


Leu Leu Gly Phe Thr Asn Ser Cys Val Asn Pro Phe Leu Tyr Cys Phe 
305                 310                 315                 320 


Val Gly Asn Arg Phe Gln Gln Lys Leu Arg Ser Val Phe Arg Val Pro 
                325                 330                 335     


Ile Thr Trp Leu Gln Gly Lys Arg Glu Ser Met Ser Cys Arg Lys Ser 
            340                 345                 350         


Ser Ser Leu Arg Glu Met Glu Thr Phe Val Ser 
        355                 360             


<210>  202
<211>  1023
<212>  PRT
<213>  Homo sapiens

<400>  202

Met Gly Lys Gly Val Gly Arg Asp Lys Tyr Glu Pro Ala Ala Val Ser 
1               5                   10                  15      


Glu Gln Gly Asp Lys Lys Gly Lys Lys Gly Lys Lys Asp Arg Asp Met 
            20                  25                  30          


Asp Glu Leu Lys Lys Glu Val Ser Met Asp Asp His Lys Leu Ser Leu 
        35                  40                  45              


Asp Glu Leu His Arg Lys Tyr Gly Thr Asp Leu Ser Arg Gly Leu Thr 
    50                  55                  60                  


Ser Ala Arg Ala Ala Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala Leu 
65                  70                  75                  80  


Thr Pro Pro Pro Thr Thr Pro Glu Trp Ile Lys Phe Cys Arg Gln Leu 
                85                  90                  95      


Phe Gly Gly Phe Ser Met Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe 
            100                 105                 110         


Leu Ala Tyr Ser Ile Gln Ala Ala Thr Glu Glu Glu Pro Gln Asn Asp 
        115                 120                 125             


Asn Leu Tyr Leu Gly Val Val Leu Ser Ala Val Val Ile Ile Thr Gly 
    130                 135                 140                 


Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Glu Ser 
145                 150                 155                 160 


Phe Lys Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Asn Gly Glu 
                165                 170                 175     


Lys Met Ser Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val Glu 
            180                 185                 190         


Val Lys Gly Gly Asp Arg Ile Pro Ala Asp Leu Arg Ile Ile Ser Ala 
        195                 200                 205             


Asn Gly Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro 
    210                 215                 220                 


Gln Thr Arg Ser Pro Asp Phe Thr Asn Glu Asn Pro Leu Glu Thr Arg 
225                 230                 235                 240 


Asn Ile Ala Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly 
                245                 250                 255     


Ile Val Val Tyr Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr 
            260                 265                 270         


Leu Ala Ser Gly Leu Glu Gly Gly Gln Thr Pro Ile Ala Ala Glu Ile 
        275                 280                 285             


Glu His Phe Ile His Ile Ile Thr Gly Val Ala Val Phe Leu Gly Val 
    290                 295                 300                 


Ser Phe Phe Ile Leu Ser Leu Ile Leu Glu Tyr Thr Trp Leu Glu Ala 
305                 310                 315                 320 


Val Ile Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu 
                325                 330                 335     


Leu Ala Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala 
            340                 345                 350         


Arg Lys Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly 
        355                 360                 365             


Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn 
    370                 375                 380                 


Arg Met Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala 
385                 390                 395                 400 


Asp Thr Thr Glu Asn Gln Ser Gly Val Ser Phe Asp Lys Thr Ser Ala 
                405                 410                 415     


Thr Trp Leu Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val 
            420                 425                 430         


Phe Gln Ala Asn Gln Glu Asn Leu Pro Ile Leu Lys Arg Ala Val Ala 
        435                 440                 445             


Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Cys Cys 
    450                 455                 460                 


Gly Ser Val Lys Glu Met Arg Glu Arg Tyr Ala Lys Ile Val Glu Ile 
465                 470                 475                 480 


Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Lys Asn Pro 
                485                 490                 495     


Asn Thr Ser Glu Pro Gln His Leu Leu Val Met Lys Gly Ala Pro Glu 
            500                 505                 510         


Arg Ile Leu Asp Arg Cys Ser Ser Ile Leu Leu His Gly Lys Glu Gln 
        515                 520                 525             


Pro Leu Asp Glu Glu Leu Lys Asp Ala Phe Gln Asn Ala Tyr Leu Glu 
    530                 535                 540                 


Leu Gly Gly Leu Gly Glu Arg Val Leu Gly Phe Cys His Leu Phe Leu 
545                 550                 555                 560 


Pro Asp Glu Gln Phe Pro Glu Gly Phe Gln Phe Asp Thr Asp Asp Val 
                565                 570                 575     


Asn Phe Pro Ile Asp Asn Leu Cys Phe Val Gly Leu Ile Ser Met Ile 
            580                 585                 590         


Asp Pro Pro Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser 
        595                 600                 605             


Ala Gly Ile Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala 
    610                 615                 620                 


Lys Ala Ile Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr 
625                 630                 635                 640 


Val Glu Asp Ile Ala Ala Arg Leu Asn Ile Pro Val Ser Gln Val Asn 
                645                 650                 655     


Pro Arg Asp Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp 
            660                 665                 670         


Met Thr Ser Glu Gln Leu Asp Asp Ile Leu Lys Tyr His Thr Glu Ile 
        675                 680                 685             


Val Phe Ala Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly 
    690                 695                 700                 


Cys Gln Arg Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn 
705                 710                 715                 720 


Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile Gly Val Ala Met Gly Ile 
                725                 730                 735     


Ala Gly Ser Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp 
            740                 745                 750         


Asp Asn Phe Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile 
        755                 760                 765             


Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile 
    770                 775                 780                 


Pro Glu Ile Thr Pro Phe Leu Ile Phe Ile Ile Ala Asn Ile Pro Leu 
785                 790                 795                 800 


Pro Leu Gly Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met 
                805                 810                 815     


Val Pro Ala Ile Ser Leu Ala Tyr Glu Gln Ala Glu Ser Asp Ile Met 
            820                 825                 830         


Lys Arg Gln Pro Arg Asn Pro Lys Thr Asp Lys Leu Val Asn Glu Arg 
        835                 840                 845             


Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly 
    850                 855                 860                 


Gly Phe Phe Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu Pro 
865                 870                 875                 880 


Ile His Leu Leu Gly Leu Arg Val Asp Trp Asp Asp Arg Trp Ile Asn 
                885                 890                 895     


Asp Val Glu Asp Ser Tyr Gly Gln Gln Trp Thr Tyr Glu Gln Arg Lys 
            900                 905                 910         


Ile Val Glu Phe Thr Cys His Thr Ala Phe Phe Val Ser Ile Val Val 
        915                 920                 925             


Val Gln Trp Ala Asp Leu Val Ile Cys Lys Thr Arg Arg Asn Ser Val 
    930                 935                 940                 


Phe Gln Gln Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Phe Glu 
945                 950                 955                 960 


Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Val 
                965                 970                 975     


Ala Leu Arg Met Tyr Pro Leu Lys Pro Thr Trp Trp Phe Cys Ala Phe 
            980                 985                 990         


Pro Tyr Ser Leu Leu Ile Phe Val  Tyr Asp Glu Val Arg  Lys Leu Ile 
        995                 1000                 1005             


Ile Arg  Arg Arg Pro Gly Gly  Trp Val Glu Lys Glu  Thr Tyr Tyr 
    1010                 1015                 1020             


<210>  203
<211>  1020
<212>  PRT
<213>  Homo sapiens

<400>  203

Met Gly Arg Gly Ala Gly Arg Glu Tyr Ser Pro Ala Ala Thr Thr Ala 
1               5                   10                  15      


Glu Asn Gly Gly Gly Lys Lys Lys Gln Lys Glu Lys Glu Leu Asp Glu 
            20                  25                  30          


Leu Lys Lys Glu Val Ala Met Asp Asp His Lys Leu Ser Leu Asp Glu 
        35                  40                  45              


Leu Gly Arg Lys Tyr Gln Val Asp Leu Ser Lys Gly Leu Thr Asn Gln 
    50                  55                  60                  


Arg Ala Gln Asp Val Leu Ala Arg Asp Gly Pro Asn Ala Leu Thr Pro 
65                  70                  75                  80  


Pro Pro Thr Thr Pro Glu Trp Val Lys Phe Cys Arg Gln Leu Phe Gly 
                85                  90                  95      


Gly Phe Ser Ile Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe Leu Ala 
            100                 105                 110         


Tyr Gly Ile Gln Ala Ala Met Glu Asp Glu Pro Ser Asn Asp Asn Leu 
        115                 120                 125             


Tyr Leu Gly Val Val Leu Ala Ala Val Val Ile Val Thr Gly Cys Phe 
    130                 135                 140                 


Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Asp Ser Phe Lys 
145                 150                 155                 160 


Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Glu Gly Glu Lys Met 
                165                 170                 175     


Gln Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val Glu Val Lys 
            180                 185                 190         


Gly Gly Asp Arg Val Pro Ala Asp Leu Arg Ile Ile Ser Ser His Gly 
        195                 200                 205             


Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro Gln Thr 
    210                 215                 220                 


Arg Ser Pro Glu Phe Thr His Glu Asn Pro Leu Glu Thr Arg Asn Ile 
225                 230                 235                 240 


Cys Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly Ile Val 
                245                 250                 255     


Ile Ala Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr Leu Ala 
            260                 265                 270         


Ser Gly Leu Glu Val Gly Arg Thr Pro Ile Ala Met Glu Ile Glu His 
        275                 280                 285             


Phe Ile Gln Leu Ile Thr Gly Val Ala Val Phe Leu Gly Val Ser Phe 
    290                 295                 300                 


Phe Val Leu Ser Leu Ile Leu Gly Tyr Ser Trp Leu Glu Ala Val Ile 
305                 310                 315                 320 


Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu Leu Ala 
                325                 330                 335     


Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala Arg Lys 
            340                 345                 350         


Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly Ser Thr 
        355                 360                 365             


Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn Arg Met 
    370                 375                 380                 


Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala Asp Thr 
385                 390                 395                 400 


Thr Glu Asp Gln Ser Gly Ala Thr Phe Asp Lys Arg Ser Pro Thr Trp 
                405                 410                 415     


Thr Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val Phe Lys 
            420                 425                 430         


Ala Gly Gln Glu Asn Ile Ser Val Ser Lys Arg Asp Thr Ala Gly Asp 
        435                 440                 445             


Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Ser Cys Gly Ser 
    450                 455                 460                 


Val Arg Lys Met Arg Asp Arg Asn Pro Lys Val Ala Glu Ile Pro Phe 
465                 470                 475                 480 


Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Glu Arg Glu Asp Ser 
                485                 490                 495     


Pro Gln Ser His Val Leu Val Met Lys Gly Ala Pro Glu Arg Ile Leu 
            500                 505                 510         


Asp Arg Cys Ser Thr Ile Leu Val Gln Gly Lys Glu Ile Pro Leu Asp 
        515                 520                 525             


Lys Glu Met Gln Asp Ala Phe Gln Asn Ala Tyr Met Glu Leu Gly Gly 
    530                 535                 540                 


Leu Gly Glu Arg Val Leu Gly Phe Cys Gln Leu Asn Leu Pro Ser Gly 
545                 550                 555                 560 


Lys Phe Pro Arg Gly Phe Lys Phe Asp Thr Asp Glu Leu Asn Phe Pro 
                565                 570                 575     


Thr Glu Lys Leu Cys Phe Val Gly Leu Met Ser Met Ile Asp Pro Pro 
            580                 585                 590         


Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser Ala Gly Ile 
        595                 600                 605             


Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala Lys Ala Ile 
    610                 615                 620                 


Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr Val Glu Asp 
625                 630                 635                 640 


Ile Ala Ala Arg Leu Asn Ile Pro Met Ser Gln Val Asn Pro Arg Glu 
                645                 650                 655     


Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp Met Thr Ser 
            660                 665                 670         


Glu Gln Leu Asp Glu Ile Leu Lys Asn His Thr Glu Ile Val Phe Ala 
        675                 680                 685             


Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly Cys Gln Arg 
    690                 695                 700                 


Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn Asp Ser Pro 
705                 710                 715                 720 


Ala Leu Lys Lys Ala Asp Ile Gly Ile Ala Met Gly Ile Ser Gly Ser 
                725                 730                 735     


Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp Asp Asn Phe 
            740                 745                 750         


Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile Phe Asp Asn 
        755                 760                 765             


Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile Pro Glu Ile 
    770                 775                 780                 


Thr Pro Phe Leu Leu Phe Ile Ile Ala Asn Ile Pro Leu Pro Leu Gly 
785                 790                 795                 800 


Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met Val Pro Ala 
                805                 810                 815     


Ile Ser Leu Ala Tyr Glu Ala Ala Glu Ser Asp Ile Met Lys Arg Gln 
            820                 825                 830         


Pro Arg Asn Ser Gln Thr Asp Lys Leu Val Asn Glu Arg Leu Ile Ser 
        835                 840                 845             


Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly Gly Phe Phe 
    850                 855                 860                 


Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu Pro Ser Arg Leu 
865                 870                 875                 880 


Leu Gly Ile Arg Leu Asp Trp Asp Asp Arg Thr Met Asn Asp Leu Glu 
                885                 890                 895     


Asp Ser Tyr Gly Gln Glu Trp Thr Tyr Glu Gln Arg Lys Val Val Glu 
            900                 905                 910         


Phe Thr Cys His Thr Ala Phe Phe Ala Ser Ile Val Val Val Gln Trp 
        915                 920                 925             


Ala Asp Leu Ile Ile Cys Lys Thr Arg Arg Asn Ser Val Phe Gln Gln 
    930                 935                 940                 


Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Leu Glu Glu Thr Ala 
945                 950                 955                 960 


Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Val Ala Leu Arg 
                965                 970                 975     


Met Tyr Pro Leu Lys Val Thr Trp Trp Phe Cys Ala Phe Pro Tyr Ser 
            980                 985                 990         


Leu Leu Ile Phe Ile Tyr Asp Glu  Val Arg Lys Leu Ile  Leu Arg Arg 
        995                 1000                 1005             


Tyr Pro  Gly Gly Trp Val Glu  Lys Glu Thr Tyr Tyr  
    1010                 1015                 1020 


<210>  204
<211>  1035
<212>  PRT
<213>  Homo sapiens

<400>  204

Met Gly Lys Ala Glu Asn Tyr Glu Leu Tyr Ser Val Glu Leu Gly Pro 
1               5                   10                  15      


Gly Pro Gly Gly Asp Met Ala Ala Lys Met Ser Lys Lys Lys Lys Ala 
            20                  25                  30          


Gly Gly Gly Gly Gly Lys Arg Lys Glu Lys Leu Glu Asn Met Lys Lys 
        35                  40                  45              


Glu Met Glu Ile Asn Asp His Gln Leu Ser Val Ala Glu Leu Glu Gln 
    50                  55                  60                  


Lys Tyr Gln Thr Ser Ala Thr Lys Gly Leu Ser Ala Ser Leu Ala Ala 
65                  70                  75                  80  


Glu Leu Leu Leu Arg Asp Gly Pro Asn Ala Leu Arg Pro Pro Arg Gly 
                85                  90                  95      


Thr Pro Glu Tyr Val Lys Phe Ala Arg Gln Leu Ala Gly Gly Leu Gln 
            100                 105                 110         


Cys Leu Met Trp Val Ala Ala Ala Ile Cys Leu Ile Ala Phe Ala Ile 
        115                 120                 125             


Gln Ala Ser Glu Gly Asp Leu Thr Thr Asp Asp Asn Leu Tyr Leu Ala 
    130                 135                 140                 


Ile Ala Leu Ile Ala Val Val Val Val Thr Gly Cys Phe Gly Tyr Tyr 
145                 150                 155                 160 


Gln Glu Phe Lys Ser Thr Asn Ile Ile Ala Ser Phe Lys Asn Leu Val 
                165                 170                 175     


Pro Gln Gln Ala Thr Val Ile Arg Asp Gly Asp Lys Phe Gln Ile Asn 
            180                 185                 190         


Ala Asp Gln Leu Val Val Gly Asp Leu Val Glu Met Lys Gly Gly Asp 
        195                 200                 205             


Arg Val Pro Ala Asp Ile Arg Ile Leu Ala Ala Gln Gly Cys Lys Val 
    210                 215                 220                 


Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro Gln Thr Arg Ser Pro 
225                 230                 235                 240 


Glu Cys Thr His Glu Ser Pro Leu Glu Thr Arg Asn Ile Ala Phe Phe 
                245                 250                 255     


Ser Thr Met Cys Leu Glu Gly Thr Val Gln Gly Leu Val Val Asn Thr 
            260                 265                 270         


Gly Asp Arg Thr Ile Ile Gly Arg Ile Ala Ser Leu Ala Ser Gly Val 
        275                 280                 285             


Glu Asn Glu Lys Thr Pro Ile Ala Ile Glu Ile Glu His Phe Val Asp 
    290                 295                 300                 


Ile Ile Ala Gly Leu Ala Ile Leu Phe Gly Ala Thr Phe Phe Ile Val 
305                 310                 315                 320 


Ala Met Cys Ile Gly Tyr Thr Phe Leu Arg Ala Met Val Phe Phe Met 
                325                 330                 335     


Ala Ile Val Val Ala Tyr Val Pro Glu Gly Leu Leu Ala Thr Val Thr 
            340                 345                 350         


Val Cys Leu Ser Leu Thr Ala Lys Arg Leu Ala Ser Lys Asn Cys Val 
        355                 360                 365             


Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly Ser Thr Ser Val Ile 
    370                 375                 380                 


Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ser 
385                 390                 395                 400 


His Leu Trp Phe Asp Asn His Ile His Thr Ala Asp Thr Thr Glu Asp 
                405                 410                 415     


Gln Ser Gly Gln Thr Phe Asp Gln Ser Ser Glu Thr Trp Arg Ala Leu 
            420                 425                 430         


Cys Arg Val Leu Thr Leu Cys Asn Arg Ala Ala Phe Lys Ser Gly Gln 
        435                 440                 445             


Asp Ala Val Pro Val Pro Lys Arg Ile Val Ile Gly Asp Ala Ser Glu 
    450                 455                 460                 


Thr Ala Leu Leu Lys Phe Ser Glu Leu Thr Leu Gly Asn Ala Met Gly 
465                 470                 475                 480 


Tyr Arg Asp Arg Phe Pro Lys Val Cys Glu Ile Pro Phe Asn Ser Thr 
                485                 490                 495     


Asn Lys Phe Gln Leu Ser Ile His Thr Leu Glu Asp Pro Arg Asp Pro 
            500                 505                 510         


Arg His Leu Leu Val Met Lys Gly Ala Pro Glu Arg Val Leu Glu Arg 
        515                 520                 525             


Cys Ser Ser Ile Leu Ile Lys Gly Gln Glu Leu Pro Leu Asp Glu Gln 
    530                 535                 540                 


Trp Arg Glu Ala Phe Gln Thr Ala Tyr Leu Ser Leu Gly Gly Leu Gly 
545                 550                 555                 560 


Glu Arg Val Leu Gly Phe Cys Gln Leu Tyr Leu Asn Glu Lys Asp Tyr 
                565                 570                 575     


Pro Pro Gly Tyr Ala Phe Asp Val Glu Ala Met Asn Phe Pro Ser Ser 
            580                 585                 590         


Gly Leu Cys Phe Ala Gly Leu Val Ser Met Ile Asp Pro Pro Arg Ala 
        595                 600                 605             


Thr Val Pro Asp Ala Val Leu Lys Cys Arg Thr Ala Gly Ile Arg Val 
    610                 615                 620                 


Ile Met Val Thr Gly Asp His Pro Ile Thr Ala Lys Ala Ile Ala Ala 
625                 630                 635                 640 


Ser Val Gly Ile Ile Ser Glu Gly Ser Glu Thr Val Glu Asp Ile Ala 
                645                 650                 655     


Ala Arg Leu Arg Val Pro Val Asp Gln Val Asn Arg Lys Asp Ala Arg 
            660                 665                 670         


Ala Cys Val Ile Asn Gly Met Gln Leu Lys Asp Met Asp Pro Ser Glu 
        675                 680                 685             


Leu Val Glu Ala Leu Arg Thr His Pro Glu Met Val Phe Ala Arg Thr 
    690                 695                 700                 


Ser Pro Gln Gln Lys Leu Val Ile Val Glu Ser Cys Gln Arg Leu Gly 
705                 710                 715                 720 


Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu 
                725                 730                 735     


Lys Lys Ala Asp Ile Gly Val Ala Met Gly Ile Ala Gly Ser Asp Ala 
            740                 745                 750         


Ala Lys Asn Ala Ala Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser 
        755                 760                 765             


Ile Val Thr Gly Val Glu Gln Gly Arg Leu Ile Phe Asp Asn Leu Lys 
    770                 775                 780                 


Lys Ser Ile Ala Tyr Thr Leu Thr Lys Asn Ile Pro Glu Leu Thr Pro 
785                 790                 795                 800 


Tyr Leu Ile Tyr Ile Thr Val Ser Val Pro Leu Pro Leu Gly Cys Ile 
                805                 810                 815     


Thr Ile Leu Phe Ile Glu Leu Cys Thr Asp Ile Phe Pro Ser Val Ser 
            820                 825                 830         


Leu Ala Tyr Glu Lys Ala Glu Ser Asp Ile Met His Leu Arg Pro Arg 
        835                 840                 845             


Asn Pro Lys Arg Asp Arg Leu Val Asn Glu Pro Leu Ala Ala Tyr Ser 
    850                 855                 860                 


Tyr Phe Gln Ile Gly Ala Ile Gln Ser Phe Ala Gly Phe Thr Asp Tyr 
865                 870                 875                 880 


Phe Thr Ala Met Ala Gln Glu Gly Trp Phe Pro Leu Leu Cys Val Gly 
                885                 890                 895     


Leu Arg Ala Gln Trp Glu Asp His His Leu Gln Asp Leu Gln Asp Ser 
            900                 905                 910         


Tyr Gly Gln Glu Trp Thr Phe Gly Gln Arg Leu Tyr Gln Gln Tyr Thr 
        915                 920                 925             


Cys Tyr Thr Val Phe Phe Ile Ser Ile Glu Val Cys Gln Ile Ala Asp 
    930                 935                 940                 


Val Leu Ile Arg Lys Thr Arg Arg Leu Ser Ala Phe Gln Gln Gly Phe 
945                 950                 955                 960 


Phe Arg Asn Lys Ile Leu Val Ile Ala Ile Val Phe Gln Val Cys Ile 
                965                 970                 975     


Gly Cys Phe Leu Cys Tyr Cys Pro Gly Met Pro Asn Ile Phe Asn Phe 
            980                 985                 990         


Met Pro Ile Arg Phe Gln Trp Trp  Leu Val Pro Leu Pro  Tyr Gly Ile 
        995                 1000                 1005             


Leu Ile  Phe Val Tyr Asp Glu  Ile Arg Lys Leu Gly  Val Arg Cys 
    1010                 1015                 1020             


Cys Pro  Gly Ser Trp Trp Asp  Gln Glu Leu Tyr Tyr  
    1025                 1030                 1035 


<210>  205
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  205

Met Ala Ala Leu Gln Glu Lys Lys Thr Cys Gly Gln Arg Met Glu Glu 
1               5                   10                  15      


Phe Gln Arg Tyr Cys Trp Asn Pro Asp Thr Gly Gln Met Leu Gly Arg 
            20                  25                  30          


Thr Leu Ser Arg Trp Val Trp Ile Ser Leu Tyr Tyr Val Ala Phe Tyr 
        35                  40                  45              


Val Val Met Thr Gly Leu Phe Ala Leu Cys Leu Tyr Val Leu Met Gln 
    50                  55                  60                  


Thr Val Asp Pro Tyr Thr Pro Asp Tyr Gln Asp Gln Leu Arg Ser Pro 
65                  70                  75                  80  


Gly Val Thr Leu Arg Pro Asp Val Tyr Gly Glu Lys Gly Leu Glu Ile 
                85                  90                  95      


Val Tyr Asn Val Ser Asp Asn Arg Thr Trp Ala Asp Leu Thr Gln Thr 
            100                 105                 110         


Leu His Ala Phe Leu Ala Gly Tyr Ser Pro Ala Ala Gln Glu Asp Ser 
        115                 120                 125             


Ile Asn Cys Thr Ser Glu Gln Tyr Phe Phe Gln Glu Ser Phe Arg Ala 
    130                 135                 140                 


Pro Asn His Thr Lys Phe Ser Cys Lys Phe Thr Ala Asp Met Leu Gln 
145                 150                 155                 160 


Asn Cys Ser Gly Leu Ala Asp Pro Asn Phe Gly Phe Glu Glu Gly Lys 
                165                 170                 175     


Pro Cys Phe Ile Ile Lys Met Asn Arg Ile Val Lys Phe Leu Pro Ser 
            180                 185                 190         


Asn Gly Ser Ala Pro Arg Val Asp Cys Ala Phe Leu Asp Gln Pro Arg 
        195                 200                 205             


Glu Leu Gly Gln Pro Leu Gln Val Lys Tyr Tyr Pro Pro Asn Gly Thr 
    210                 215                 220                 


Phe Ser Leu His Tyr Phe Pro Tyr Tyr Gly Lys Lys Ala Gln Pro His 
225                 230                 235                 240 


Tyr Ser Asn Pro Leu Val Ala Ala Lys Leu Leu Asn Ile Pro Arg Asn 
                245                 250                 255     


Ala Glu Val Ala Ile Val Cys Lys Val Met Ala Glu His Val Thr Phe 
            260                 265                 270         


Asn Asn Pro His Asp Pro Tyr Glu Gly Lys Val Glu Phe Lys Leu Lys 
        275                 280                 285             


Ile Glu Lys 
    290     


<210>  206
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  206

Met Arg Leu Ser Ala Gly Pro Asp Ala Gly Pro Ser Gly Asn Ser Ser 
1               5                   10                  15      


Pro Trp Trp Pro Leu Ala Thr Gly Ala Gly Asn Thr Ser Arg Glu Ala 
            20                  25                  30          


Glu Ala Leu Gly Glu Gly Asn Gly Pro Pro Arg Asp Val Arg Asn Glu 
        35                  40                  45              


Glu Leu Ala Lys Leu Glu Ile Ala Val Leu Ala Val Thr Phe Ala Val 
    50                  55                  60                  


Ala Val Leu Gly Asn Ser Ser Val Leu Leu Ala Leu His Arg Thr Pro 
65                  70                  75                  80  


Arg Lys Thr Ser Arg Met His Leu Phe Ile Arg His Leu Ser Leu Ala 
                85                  90                  95      


Asp Leu Ala Val Ala Phe Phe Gln Val Leu Pro Gln Met Cys Trp Asp 
            100                 105                 110         


Ile Thr Tyr Arg Phe Arg Gly Pro Asp Trp Leu Cys Arg Val Val Lys 
        115                 120                 125             


His Leu Gln Val Phe Gly Met Phe Ala Ser Ala Tyr Met Leu Val Val 
    130                 135                 140                 


Met Thr Ala Asp Arg Tyr Ile Ala Val Cys His Pro Leu Lys Thr Leu 
145                 150                 155                 160 


Gln Gln Pro Ala Arg Arg Ser Arg Leu Met Ile Ala Ala Ala Trp Val 
                165                 170                 175     


Leu Ser Phe Val Leu Ser Thr Pro Gln Tyr Phe Val Phe Ser Met Ile 
            180                 185                 190         


Glu Val Asn Asn Val Thr Lys Ala Arg Asp Cys Trp Ala Thr Phe Ile 
        195                 200                 205             


Gln Pro Trp Gly Ser Arg Ala Tyr Val Thr Trp Met Thr Gly Gly Ile 
    210                 215                 220                 


Phe Val Ala Pro Val Val Ile Leu Gly Thr Cys Tyr Gly Phe Ile Cys 
225                 230                 235                 240 


Tyr Asn Ile Trp Cys Asn Val Arg Gly Lys Thr Ala Ser Arg Gln Ser 
                245                 250                 255     


Lys Gly Ala Glu Gln Ala Gly Val Ala Phe Gln Lys Gly Phe Leu Leu 
            260                 265                 270         


Ala Pro Cys Val Ser Ser Val Lys Ser Ile Ser Arg Ala Lys Ile Arg 
        275                 280                 285             


Thr Val Lys Met Thr Phe Val Ile Val Thr Ala Tyr Ile Val Cys Trp 
    290                 295                 300                 


Ala Pro Phe Phe Ile Ile Gln Met Trp Ser Val Trp Asp Pro Met Ser 
305                 310                 315                 320 


Val Trp Thr Glu Ser Glu Asn Pro Thr Ile Thr Ile Thr Ala Leu Leu 
                325                 330                 335     


Gly Ser Leu Asn Ser Cys Cys Asn Pro Trp Ile Tyr Met Phe Phe Ser 
            340                 345                 350         


Gly His Leu Leu Gln Asp Cys Val Gln Ser Phe Pro Cys Cys Gln Asn 
        355                 360                 365             


Met Lys Glu Lys Phe Asn Lys Glu Asp Thr Asp Ser Met Ser Arg Arg 
    370                 375                 380                 


Gln Thr Phe Tyr Ser Asn Asn Arg Ser Pro Thr Asn Ser Thr Gly Met 
385                 390                 395                 400 


Trp Lys Asp Ser Pro Lys Ser Ser Lys Ser Ile Lys Phe Ile Pro Val 
                405                 410                 415     


Ser Thr 
        


<210>  207
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  207

Met Asp Ser Gly Pro Leu Trp Asp Ala Asn Pro Thr Pro Arg Gly Thr 
1               5                   10                  15      


Leu Ser Ala Pro Asn Ala Thr Thr Pro Trp Leu Gly Arg Asp Glu Glu 
            20                  25                  30          


Leu Ala Lys Val Glu Ile Gly Val Leu Ala Thr Val Leu Val Leu Ala 
        35                  40                  45              


Thr Gly Gly Asn Leu Ala Val Leu Leu Thr Leu Gly Gln Leu Gly Arg 
    50                  55                  60                  


Lys Arg Ser Arg Met His Leu Phe Val Leu His Leu Ala Leu Thr Asp 
65                  70                  75                  80  


Leu Ala Val Ala Leu Phe Gln Val Leu Pro Gln Leu Leu Trp Asp Ile 
                85                  90                  95      


Thr Tyr Arg Phe Gln Gly Pro Asp Leu Leu Cys Arg Ala Val Lys Tyr 
            100                 105                 110         


Leu Gln Val Leu Ser Met Phe Ala Ser Thr Tyr Met Leu Leu Ala Met 
        115                 120                 125             


Thr Leu Asp Arg Tyr Leu Ala Val Cys His Pro Leu Arg Ser Leu Gln 
    130                 135                 140                 


Gln Pro Gly Gln Ser Thr Tyr Leu Leu Ile Ala Ala Pro Trp Leu Leu 
145                 150                 155                 160 


Ala Ala Ile Phe Ser Leu Pro Gln Val Phe Ile Phe Ser Leu Arg Glu 
                165                 170                 175     


Val Ile Gln Gly Ser Gly Val Leu Asp Cys Trp Ala Asp Phe Gly Phe 
            180                 185                 190         


Pro Trp Gly Pro Arg Ala Tyr Leu Thr Trp Thr Thr Leu Ala Ile Phe 
        195                 200                 205             


Val Leu Pro Val Thr Met Leu Thr Ala Cys Tyr Ser Leu Ile Cys His 
    210                 215                 220                 


Glu Ile Cys Lys Asn Leu Lys Val Lys Thr Gln Ala Trp Arg Val Gly 
225                 230                 235                 240 


Gly Gly Gly Trp Arg Thr Trp Asp Arg Pro Ser Pro Ser Thr Leu Ala 
                245                 250                 255     


Ala Thr Thr Arg Gly Leu Pro Ser Arg Val Ser Ser Ile Asn Thr Ile 
            260                 265                 270         


Ser Arg Ala Lys Ile Arg Thr Val Lys Met Thr Phe Val Ile Val Leu 
        275                 280                 285             


Ala Tyr Ile Ala Cys Trp Ala Pro Phe Phe Ser Val Gln Met Trp Ser 
    290                 295                 300                 


Val Trp Asp Lys Asn Ala Pro Asp Glu Asp Ser Thr Asn Val Ala Phe 
305                 310                 315                 320 


Thr Ile Ser Met Leu Leu Gly Asn Leu Asn Ser Cys Cys Asn Pro Trp 
                325                 330                 335     


Ile Tyr Met Gly Phe Asn Ser His Leu Leu Pro Arg Pro Leu Arg His 
            340                 345                 350         


Leu Ala Cys Cys Gly Gly Pro Gln Pro Arg Met Arg Arg Arg Leu Ser 
        355                 360                 365             


Asp Gly Ser Leu Ser Ser Arg His Thr Thr Leu Leu Thr Arg Ser Ser 
    370                 375                 380                 


Cys Pro Ala Thr Leu Ser Leu Ser Leu Ser Leu Thr Leu Ser Gly Arg 
385                 390                 395                 400 


Pro Arg Pro Glu Glu Ser Pro Arg Asp Leu Glu Leu Ala Asp Gly Glu 
                405                 410                 415     


Gly Thr Ala Glu Thr Ile Ile Phe 
            420                 


<210>  208
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  208

Met Ala Ser Ser Trp Pro Pro Leu Glu Leu Gln Ser Ser Asn Gln Ser 
1               5                   10                  15      


Gln Leu Phe Pro Gln Asn Ala Thr Ala Cys Asp Asn Ala Pro Glu Ala 
            20                  25                  30          


Trp Asp Leu Leu His Arg Val Leu Pro Thr Phe Ile Ile Ser Ile Cys 
        35                  40                  45              


Phe Phe Gly Leu Leu Gly Asn Leu Phe Val Leu Leu Val Phe Leu Leu 
    50                  55                  60                  


Pro Arg Arg Gln Leu Asn Val Ala Glu Ile Tyr Leu Ala Asn Leu Ala 
65                  70                  75                  80  


Ala Ser Asp Leu Val Phe Val Leu Gly Leu Pro Phe Trp Ala Glu Asn 
                85                  90                  95      


Ile Trp Asn Gln Phe Asn Trp Pro Phe Gly Ala Leu Leu Cys Arg Val 
            100                 105                 110         


Ile Asn Gly Val Ile Lys Ala Asn Leu Phe Ile Ser Ile Phe Leu Val 
        115                 120                 125             


Val Ala Ile Ser Gln Asp Arg Tyr Arg Val Leu Val His Pro Met Ala 
    130                 135                 140                 


Ser Arg Arg Gln Gln Arg Arg Arg Gln Ala Arg Val Thr Cys Val Leu 
145                 150                 155                 160 


Ile Trp Val Val Gly Gly Leu Leu Ser Ile Pro Thr Phe Leu Leu Arg 
                165                 170                 175     


Ser Ile Gln Ala Val Pro Asp Leu Asn Ile Thr Ala Cys Ile Leu Leu 
            180                 185                 190         


Leu Pro His Glu Ala Trp His Phe Ala Arg Ile Val Glu Leu Asn Ile 
        195                 200                 205             


Leu Gly Phe Leu Leu Pro Leu Ala Ala Ile Val Phe Phe Asn Tyr His 
    210                 215                 220                 


Ile Leu Ala Ser Leu Arg Thr Arg Glu Glu Val Ser Arg Thr Arg Cys 
225                 230                 235                 240 


Gly Gly Arg Lys Asp Ser Lys Thr Thr Ala Leu Ile Leu Thr Leu Val 
                245                 250                 255     


Val Ala Phe Leu Val Cys Trp Ala Pro Tyr His Phe Phe Ala Phe Leu 
            260                 265                 270         


Glu Phe Leu Phe Gln Val Gln Ala Val Arg Gly Cys Phe Trp Glu Asp 
        275                 280                 285             


Phe Ile Asp Leu Gly Leu Gln Leu Ala Asn Phe Phe Ala Phe Thr Asn 
    290                 295                 300                 


Ser Ser Leu Asn Pro Val Ile Tyr Val Phe Val Gly Arg Leu Phe Arg 
305                 310                 315                 320 


Thr Lys Val Trp Glu Leu Tyr Lys Gln Cys Thr Pro Lys Ser Leu Ala 
                325                 330                 335     


Pro Ile Ser Ser Ser His Arg Lys Glu Ile Phe Gln Leu Phe Trp Arg 
            340                 345                 350         


Asn 
    


<210>  209
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  209

Met Ala Pro Pro Trp Val Pro Ala Met Gly Phe Thr Leu Ala Pro Ser 
1               5                   10                  15      


Leu Gly Cys Phe Val Gly Ser Arg Phe Val His Gly Glu Gly Leu Arg 
            20                  25                  30          


Trp Tyr Ala Gly Leu Gln Lys Pro Ser Trp His Pro Pro His Trp Val 
        35                  40                  45              


Leu Gly Pro Val Trp Gly Thr Leu Tyr Ser Ala Met Gly Tyr Gly Ser 
    50                  55                  60                  


Tyr Leu Val Trp Lys Glu Leu Gly Gly Phe Thr Glu Lys Ala Val Val 
65                  70                  75                  80  


Pro Leu Gly Leu Tyr Thr Gly Gln Leu Ala Leu Asn Trp Ala Trp Pro 
                85                  90                  95      


Pro Ile Phe Phe Gly Ala Arg Gln Met Gly Trp Ala Leu Val Asp Leu 
            100                 105                 110         


Leu Leu Val Ser Gly Ala Ala Ala Ala Thr Thr Val Ala Trp Tyr Gln 
        115                 120                 125             


Val Ser Pro Leu Ala Ala Arg Leu Leu Tyr Pro Tyr Leu Ala Trp Leu 
    130                 135                 140                 


Ala Phe Thr Thr Thr Leu Asn Tyr Cys Val Trp Arg Asp Asn His Gly 
145                 150                 155                 160 


Trp Arg Gly Gly Arg Arg Leu Pro Glu 
                165                 


<210>  210
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  210

Met Arg Met Leu Leu Ala Leu Leu Ala Leu Ser Ala Ala Arg Pro Ser 
1               5                   10                  15      


Ala Ser Ala Glu Ser His Trp Cys Tyr Glu Val Gln Ala Glu Ser Ser 
            20                  25                  30          


Asn Tyr Pro Cys Leu Val Pro Val Lys Trp Gly Gly Asn Cys Gln Lys 
        35                  40                  45              


Asp Arg Gln Ser Pro Ile Asn Ile Val Thr Thr Lys Ala Lys Val Asp 
    50                  55                  60                  


Lys Lys Leu Gly Arg Phe Phe Phe Ser Gly Tyr Asp Lys Lys Gln Thr 
65                  70                  75                  80  


Trp Thr Val Gln Asn Asn Gly His Ser Val Met Met Leu Leu Glu Asn 
                85                  90                  95      


Lys Ala Ser Ile Ser Gly Gly Gly Leu Pro Ala Pro Tyr Gln Ala Lys 
            100                 105                 110         


Gln Leu His Leu His Trp Ser Asp Leu Pro Tyr Lys Gly Ser Glu His 
        115                 120                 125             


Ser Leu Asp Gly Glu His Phe Ala Met Glu Met His Ile Val His Glu 
    130                 135                 140                 


Lys Glu Lys Gly Thr Ser Arg Asn Val Lys Glu Ala Gln Asp Pro Glu 
145                 150                 155                 160 


Asp Glu Ile Ala Val Leu Ala Phe Leu Val Glu Ala Gly Thr Gln Val 
                165                 170                 175     


Asn Glu Gly Phe Gln Pro Leu Val Glu Ala Leu Ser Asn Ile Pro Lys 
            180                 185                 190         


Pro Glu Met Ser Thr Thr Met Ala Glu Ser Ser Leu Leu Asp Leu Leu 
        195                 200                 205             


Pro Lys Glu Glu Lys Leu Arg His Tyr Phe Arg Tyr Leu Gly Ser Leu 
    210                 215                 220                 


Thr Thr Pro Thr Cys Asp Glu Lys Val Val Trp Thr Val Phe Arg Glu 
225                 230                 235                 240 


Pro Ile Gln Leu His Arg Glu Gln Ile Leu Ala Phe Ser Gln Lys Leu 
                245                 250                 255     


Tyr Tyr Asp Lys Glu Gln Thr Val Ser Met Lys Asp Asn Val Arg Pro 
            260                 265                 270         


Leu Gln Gln Leu Gly Gln Arg Thr Val Ile Lys Ser Gly Ala Pro Gly 
        275                 280                 285             


Arg Pro Leu Pro Trp Ala Leu Pro Ala Leu Leu Gly Pro Met Leu Ala 
    290                 295                 300                 


Cys Leu Leu Ala Gly Phe Leu Arg 
305                 310         


<210>  211
<211>  2339
<212>  PRT
<213>  Homo sapiens

<400>  211

Met Val Arg Phe Gly Asp Glu Leu Gly Gly Arg Tyr Gly Gly Pro Gly 
1               5                   10                  15      


Gly Gly Glu Arg Ala Arg Gly Gly Gly Ala Gly Gly Ala Gly Gly Pro 
            20                  25                  30          


Gly Pro Gly Gly Leu Gln Pro Gly Gln Arg Val Leu Tyr Lys Gln Ser 
        35                  40                  45              


Ile Ala Gln Arg Ala Arg Thr Met Ala Leu Tyr Asn Pro Ile Pro Val 
    50                  55                  60                  


Lys Gln Asn Cys Phe Thr Val Asn Arg Ser Leu Phe Val Phe Ser Glu 
65                  70                  75                  80  


Asp Asn Val Val Arg Lys Tyr Ala Lys Arg Ile Thr Glu Trp Pro Pro 
                85                  90                  95      


Phe Glu Tyr Met Ile Leu Ala Thr Ile Ile Ala Asn Cys Ile Val Leu 
            100                 105                 110         


Ala Leu Glu Gln His Leu Pro Asp Gly Asp Lys Thr Pro Met Ser Glu 
        115                 120                 125             


Arg Leu Asp Asp Thr Glu Pro Tyr Phe Ile Gly Ile Phe Cys Phe Glu 
    130                 135                 140                 


Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Val Phe His Lys Gly Ser 
145                 150                 155                 160 


Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val Val Val Leu Thr 
                165                 170                 175     


Gly Ile Leu Ala Thr Ala Gly Thr Asp Phe Asp Leu Arg Thr Leu Arg 
            180                 185                 190         


Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly Ile Pro Ser 
        195                 200                 205             


Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met Val Pro Leu Leu 
    210                 215                 220                 


Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Met Phe Ala Ile Ile 
225                 230                 235                 240 


Gly Leu Glu Phe Tyr Met Gly Lys Phe His Lys Ala Cys Phe Pro Asn 
                245                 250                 255     


Ser Thr Asp Ala Glu Pro Val Gly Asp Phe Pro Cys Gly Lys Glu Ala 
            260                 265                 270         


Pro Ala Arg Leu Cys Glu Gly Asp Thr Glu Cys Arg Glu Tyr Trp Pro 
        275                 280                 285             


Gly Pro Asn Phe Gly Ile Thr Asn Phe Asp Asn Ile Leu Phe Ala Ile 
    290                 295                 300                 


Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Ile Leu 
305                 310                 315                 320 


Tyr Asn Thr Asn Asp Ala Ala Gly Asn Thr Trp Asn Trp Leu Tyr Phe 
                325                 330                 335     


Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met Leu Asn Leu Val Leu 
            340                 345                 350         


Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg Glu Arg Val Glu Asn 
        355                 360                 365             


Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln Gln Ile Glu Arg Glu 
    370                 375                 380                 


Leu Asn Gly Tyr Leu Glu Trp Ile Phe Lys Ala Glu Glu Val Met Leu 
385                 390                 395                 400 


Ala Glu Glu Asp Arg Asn Ala Glu Glu Lys Ser Pro Leu Asp Val Leu 
                405                 410                 415     


Lys Arg Ala Ala Thr Lys Lys Ser Arg Asn Asp Leu Ile His Ala Glu 
            420                 425                 430         


Glu Gly Glu Asp Arg Phe Ala Asp Leu Cys Ala Val Gly Ser Pro Phe 
        435                 440                 445             


Ala Arg Ala Ser Leu Lys Ser Gly Lys Thr Glu Ser Ser Ser Tyr Phe 
    450                 455                 460                 


Arg Arg Lys Glu Lys Met Phe Arg Phe Phe Ile Arg Arg Met Val Lys 
465                 470                 475                 480 


Ala Gln Ser Phe Tyr Trp Val Val Leu Cys Val Val Ala Leu Asn Thr 
                485                 490                 495     


Leu Cys Val Ala Met Val His Tyr Asn Gln Pro Arg Arg Leu Thr Thr 
            500                 505                 510         


Thr Leu Tyr Phe Ala Glu Phe Val Phe Leu Gly Leu Phe Leu Thr Glu 
        515                 520                 525             


Met Ser Leu Lys Met Tyr Gly Leu Gly Pro Arg Ser Tyr Phe Arg Ser 
    530                 535                 540                 


Ser Phe Asn Cys Phe Asp Phe Gly Val Ile Val Gly Ser Val Phe Glu 
545                 550                 555                 560 


Val Val Trp Ala Ala Ile Lys Pro Gly Ser Ser Phe Gly Ile Ser Val 
                565                 570                 575     


Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys Val Thr Lys Tyr Trp 
            580                 585                 590         


Ser Ser Leu Arg Asn Leu Val Val Ser Leu Leu Asn Ser Met Lys Ser 
        595                 600                 605             


Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu Phe Ile Val Val Phe Ala 
    610                 615                 620                 


Leu Leu Gly Met Gln Leu Phe Gly Gly Gln Phe Asn Phe Gln Asp Glu 
625                 630                 635                 640 


Thr Pro Thr Thr Asn Phe Asp Thr Phe Pro Ala Ala Ile Leu Thr Val 
                645                 650                 655     


Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Ala Val Met Tyr His Gly 
            660                 665                 670         


Ile Glu Ser Gln Gly Gly Val Ser Lys Gly Met Phe Ser Ser Phe Tyr 
        675                 680                 685             


Phe Ile Val Leu Thr Leu Phe Gly Asn Tyr Thr Leu Leu Asn Val Phe 
    690                 695                 700                 


Leu Ala Ile Ala Val Asp Asn Leu Ala Asn Ala Gln Glu Leu Thr Lys 
705                 710                 715                 720 


Asp Glu Glu Glu Met Glu Glu Ala Ala Asn Gln Lys Leu Ala Leu Gln 
                725                 730                 735     


Lys Ala Lys Glu Val Ala Glu Val Ser Pro Met Ser Ala Ala Asn Ile 
            740                 745                 750         


Ser Ile Ala Ala Arg Gln Gln Asn Ser Ala Lys Ala Arg Ser Val Trp 
        755                 760                 765             


Glu Gln Arg Ala Ser Gln Leu Arg Leu Gln Asn Leu Arg Ala Ser Cys 
    770                 775                 780                 


Glu Ala Leu Tyr Ser Glu Met Asp Pro Glu Glu Arg Leu Arg Phe Ala 
785                 790                 795                 800 


Thr Thr Arg His Leu Arg Pro Asp Met Lys Thr His Leu Asp Arg Pro 
                805                 810                 815     


Leu Val Val Glu Leu Gly Arg Asp Gly Ala Arg Gly Pro Val Gly Gly 
            820                 825                 830         


Lys Ala Arg Pro Glu Ala Ala Glu Ala Pro Glu Gly Val Asp Pro Pro 
        835                 840                 845             


Arg Arg His His Arg His Arg Asp Lys Asp Lys Thr Pro Ala Ala Gly 
    850                 855                 860                 


Asp Gln Asp Arg Ala Glu Ala Pro Lys Ala Glu Ser Gly Glu Pro Gly 
865                 870                 875                 880 


Ala Arg Glu Glu Arg Pro Arg Pro His Arg Ser His Ser Lys Glu Ala 
                885                 890                 895     


Ala Gly Pro Pro Glu Ala Arg Ser Glu Arg Gly Arg Gly Pro Gly Pro 
            900                 905                 910         


Glu Gly Gly Arg Arg His His Arg Arg Gly Ser Pro Glu Glu Ala Ala 
        915                 920                 925             


Glu Arg Glu Pro Arg Arg His Arg Ala His Arg His Gln Asp Pro Ser 
    930                 935                 940                 


Lys Glu Cys Ala Gly Ala Lys Gly Glu Arg Arg Ala Arg His Arg Gly 
945                 950                 955                 960 


Gly Pro Arg Ala Gly Pro Arg Glu Ala Glu Ser Gly Glu Glu Pro Ala 
                965                 970                 975     


Arg Arg His Arg Ala Arg His Lys Ala Gln Pro Ala His Glu Ala Val 
            980                 985                 990         


Glu Lys Glu Thr Thr Glu Lys Glu  Ala Thr Glu Lys Glu  Ala Glu Ile 
        995                 1000                 1005             


Val Glu  Ala Asp Lys Glu Lys  Glu Leu Arg Asn His  Gln Pro Arg 
    1010                 1015                 1020             


Glu Pro  His Cys Asp Leu Glu  Thr Ser Gly Thr Val  Thr Val Gly 
    1025                 1030                 1035             


Pro Met  His Thr Leu Pro Ser  Thr Cys Leu Gln Lys  Val Glu Glu 
    1040                 1045                 1050             


Gln Pro  Glu Asp Ala Asp Asn  Gln Arg Asn Val Thr  Arg Met Gly 
    1055                 1060                 1065             


Ser Gln  Pro Pro Asp Pro Asn  Thr Ile Val His Ile  Pro Val Met 
    1070                 1075                 1080             


Leu Thr  Gly Pro Leu Gly Glu  Ala Thr Val Val Pro  Ser Gly Asn 
    1085                 1090                 1095             


Val Asp  Leu Glu Ser Gln Ala  Glu Gly Lys Lys Glu  Val Glu Ala 
    1100                 1105                 1110             


Asp Asp  Val Met Arg Ser Gly  Pro Arg Pro Ile Val  Pro Tyr Ser 
    1115                 1120                 1125             


Ser Met  Phe Cys Leu Ser Pro  Thr Asn Leu Leu Arg  Arg Phe Cys 
    1130                 1135                 1140             


His Tyr  Ile Val Thr Met Arg  Tyr Phe Glu Val Val  Ile Leu Val 
    1145                 1150                 1155             


Val Ile  Ala Leu Ser Ser Ile  Ala Leu Ala Ala Glu  Asp Pro Val 
    1160                 1165                 1170             


Arg Thr  Asp Ser Pro Arg Asn  Asn Ala Leu Lys Tyr  Leu Asp Tyr 
    1175                 1180                 1185             


Ile Phe  Thr Gly Val Phe Thr  Phe Glu Met Val Ile  Lys Met Ile 
    1190                 1195                 1200             


Asp Leu  Gly Leu Leu Leu His  Pro Gly Ala Tyr Phe  Arg Asp Leu 
    1205                 1210                 1215             


Trp Asn  Ile Leu Asp Phe Ile  Val Val Ser Gly Ala  Leu Val Ala 
    1220                 1225                 1230             


Phe Ala  Phe Ser Gly Ser Lys  Gly Lys Asp Ile Asn  Thr Ile Lys 
    1235                 1240                 1245             


Ser Leu  Arg Val Leu Arg Val  Leu Arg Pro Leu Lys  Thr Ile Lys 
    1250                 1255                 1260             


Arg Leu  Pro Lys Leu Lys Ala  Val Phe Asp Cys Val  Val Asn Ser 
    1265                 1270                 1275             


Leu Lys  Asn Val Leu Asn Ile  Leu Ile Val Tyr Met  Leu Phe Met 
    1280                 1285                 1290             


Phe Ile  Phe Ala Val Ile Ala  Val Gln Leu Phe Lys  Gly Lys Phe 
    1295                 1300                 1305             


Phe Tyr  Cys Thr Asp Glu Ser  Lys Glu Leu Glu Arg  Asp Cys Arg 
    1310                 1315                 1320             


Gly Gln  Tyr Leu Asp Tyr Glu  Lys Glu Glu Val Glu  Ala Gln Pro 
    1325                 1330                 1335             


Arg Gln  Trp Lys Lys Tyr Asp  Phe His Tyr Asp Asn  Val Leu Trp 
    1340                 1345                 1350             


Ala Leu  Leu Thr Leu Phe Thr  Val Ser Thr Gly Glu  Gly Trp Pro 
    1355                 1360                 1365             


Met Val  Leu Lys His Ser Val  Asp Ala Thr Tyr Glu  Glu Gln Gly 
    1370                 1375                 1380             


Pro Ser  Pro Gly Tyr Arg Met  Glu Leu Ser Ile Phe  Tyr Val Val 
    1385                 1390                 1395             


Tyr Phe  Val Val Phe Pro Phe  Phe Phe Val Asn Ile  Phe Val Ala 
    1400                 1405                 1410             


Leu Ile  Ile Ile Thr Phe Gln  Glu Gln Gly Asp Lys  Val Met Ser 
    1415                 1420                 1425             


Glu Cys  Ser Leu Glu Lys Asn  Glu Arg Ala Cys Ile  Asp Phe Ala 
    1430                 1435                 1440             


Ile Ser  Ala Lys Pro Leu Thr  Arg Tyr Met Pro Gln  Asn Arg Gln 
    1445                 1450                 1455             


Ser Phe  Gln Tyr Lys Thr Trp  Thr Phe Val Val Ser  Pro Pro Phe 
    1460                 1465                 1470             


Glu Tyr  Phe Ile Met Ala Met  Ile Ala Leu Asn Thr  Val Val Leu 
    1475                 1480                 1485             


Met Met  Lys Phe Tyr Asp Ala  Pro Tyr Glu Tyr Glu  Leu Met Leu 
    1490                 1495                 1500             


Lys Cys  Leu Asn Ile Val Phe  Thr Ser Met Phe Ser  Met Glu Cys 
    1505                 1510                 1515             


Val Leu  Lys Ile Ile Ala Phe  Gly Val Leu Asn Tyr  Phe Arg Asp 
    1520                 1525                 1530             


Ala Trp  Asn Val Phe Asp Phe  Val Thr Val Leu Gly  Ser Ile Thr 
    1535                 1540                 1545             


Asp Ile  Leu Val Thr Glu Ile  Ala Glu Thr Asn Asn  Phe Ile Asn 
    1550                 1555                 1560             


Leu Ser  Phe Leu Arg Leu Phe  Arg Ala Ala Arg Leu  Ile Lys Leu 
    1565                 1570                 1575             


Leu Arg  Gln Gly Tyr Thr Ile  Arg Ile Leu Leu Trp  Thr Phe Val 
    1580                 1585                 1590             


Gln Ser  Phe Lys Ala Leu Pro  Tyr Val Cys Leu Leu  Ile Ala Met 
    1595                 1600                 1605             


Leu Phe  Phe Ile Tyr Ala Ile  Ile Gly Met Gln Val  Phe Gly Asn 
    1610                 1615                 1620             


Ile Ala  Leu Asp Asp Asp Thr  Ser Ile Asn Arg His  Asn Asn Phe 
    1625                 1630                 1635             


Arg Thr  Phe Leu Gln Ala Leu  Met Leu Leu Phe Arg  Ser Ala Thr 
    1640                 1645                 1650             


Gly Glu  Ala Trp His Glu Ile  Met Leu Ser Cys Leu  Ser Asn Gln 
    1655                 1660                 1665             


Ala Cys  Asp Glu Gln Ala Asn  Ala Thr Glu Cys Gly  Ser Asp Phe 
    1670                 1675                 1680             


Ala Tyr  Phe Tyr Phe Val Ser  Phe Ile Phe Leu Cys  Ser Phe Leu 
    1685                 1690                 1695             


Met Leu  Asn Leu Phe Val Ala  Val Ile Met Asp Asn  Phe Glu Tyr 
    1700                 1705                 1710             


Leu Thr  Arg Asp Ser Ser Ile  Leu Gly Pro His His  Leu Asp Glu 
    1715                 1720                 1725             


Phe Ile  Arg Val Trp Ala Glu  Tyr Asp Pro Ala Ala  Cys Gly Arg 
    1730                 1735                 1740             


Ile Ser  Tyr Asn Asp Met Phe  Glu Met Leu Lys His  Met Ser Pro 
    1745                 1750                 1755             


Pro Leu  Gly Leu Gly Lys Lys  Cys Pro Ala Arg Val  Ala Tyr Lys 
    1760                 1765                 1770             


Arg Leu  Val Arg Met Asn Met  Pro Ile Ser Asn Glu  Asp Met Thr 
    1775                 1780                 1785             


Val His  Phe Thr Ser Thr Leu  Met Ala Leu Ile Arg  Thr Ala Leu 
    1790                 1795                 1800             


Glu Ile  Lys Leu Ala Pro Ala  Gly Thr Lys Gln His  Gln Cys Asp 
    1805                 1810                 1815             


Ala Glu  Leu Arg Lys Glu Ile  Ser Val Val Trp Ala  Asn Leu Pro 
    1820                 1825                 1830             


Gln Lys  Thr Leu Asp Leu Leu  Val Pro Pro His Lys  Pro Asp Glu 
    1835                 1840                 1845             


Met Thr  Val Gly Lys Val Tyr  Ala Ala Leu Met Ile  Phe Asp Phe 
    1850                 1855                 1860             


Tyr Lys  Gln Asn Lys Thr Thr  Arg Asp Gln Met Gln  Gln Ala Pro 
    1865                 1870                 1875             


Gly Gly  Leu Ser Gln Met Gly  Pro Val Ser Leu Phe  His Pro Leu 
    1880                 1885                 1890             


Lys Ala  Thr Leu Glu Gln Thr  Gln Pro Ala Val Leu  Arg Gly Ala 
    1895                 1900                 1905             


Arg Val  Phe Leu Arg Gln Lys  Ser Ser Thr Ser Leu  Ser Asn Gly 
    1910                 1915                 1920             


Gly Ala  Ile Gln Asn Gln Glu  Ser Gly Ile Lys Glu  Ser Val Ser 
    1925                 1930                 1935             


Trp Gly  Thr Gln Arg Thr Gln  Asp Ala Pro His Glu  Ala Arg Pro 
    1940                 1945                 1950             


Pro Leu  Glu Arg Gly His Ser  Thr Glu Ile Pro Val  Gly Arg Ser 
    1955                 1960                 1965             


Gly Ala  Leu Ala Val Asp Val  Gln Met Gln Ser Ile  Thr Arg Arg 
    1970                 1975                 1980             


Gly Pro  Asp Gly Glu Pro Gln  Pro Gly Leu Glu Ser  Gln Gly Arg 
    1985                 1990                 1995             


Ala Ala  Ser Met Pro Arg Leu  Ala Ala Glu Thr Gln  Pro Val Thr 
    2000                 2005                 2010             


Asp Ala  Ser Pro Met Lys Arg  Ser Ile Ser Thr Leu  Ala Gln Arg 
    2015                 2020                 2025             


Pro Arg  Gly Thr His Leu Cys  Ser Thr Thr Pro Asp  Arg Pro Pro 
    2030                 2035                 2040             


Pro Ser  Gln Ala Ser Ser His  His His His His Arg  Cys His Arg 
    2045                 2050                 2055             


Arg Arg  Asp Arg Lys Gln Arg  Ser Leu Glu Lys Gly  Pro Ser Leu 
    2060                 2065                 2070             


Ser Ala  Asp Met Asp Gly Ala  Pro Ser Ser Ala Val  Gly Pro Gly 
    2075                 2080                 2085             


Leu Pro  Pro Gly Glu Gly Pro  Thr Gly Cys Arg Arg  Glu Arg Glu 
    2090                 2095                 2100             


Arg Arg  Gln Glu Arg Gly Arg  Ser Gln Glu Arg Arg  Gln Pro Ser 
    2105                 2110                 2115             


Ser Ser  Ser Ser Glu Lys Gln  Arg Phe Tyr Ser Cys  Asp Arg Phe 
    2120                 2125                 2130             


Gly Gly  Arg Glu Pro Pro Lys  Pro Lys Pro Ser Leu  Ser Ser His 
    2135                 2140                 2145             


Pro Thr  Ser Pro Thr Ala Gly  Gln Glu Pro Gly Pro  His Pro Gln 
    2150                 2155                 2160             


Gly Ser  Gly Ser Val Asn Gly  Ser Pro Leu Leu Ser  Thr Ser Gly 
    2165                 2170                 2175             


Ala Ser  Thr Pro Gly Arg Gly  Gly Arg Arg Gln Leu  Pro Gln Thr 
    2180                 2185                 2190             


Pro Leu  Thr Pro Arg Pro Ser  Ile Thr Tyr Lys Thr  Ala Asn Ser 
    2195                 2200                 2205             


Ser Pro  Ile His Phe Ala Gly  Ala Gln Thr Ser Leu  Pro Ala Phe 
    2210                 2215                 2220             


Ser Pro  Gly Arg Leu Ser Arg  Gly Leu Ser Glu His  Asn Ala Leu 
    2225                 2230                 2235             


Leu Gln  Arg Asp Pro Leu Ser  Gln Pro Leu Ala Pro  Gly Ser Arg 
    2240                 2245                 2250             


Ile Gly  Ser Asp Pro Tyr Leu  Gly Gln Arg Leu Asp  Ser Glu Ala 
    2255                 2260                 2265             


Ser Val  His Ala Leu Pro Glu  Asp Thr Leu Thr Phe  Glu Glu Ala 
    2270                 2275                 2280             


Val Ala  Thr Asn Ser Gly Arg  Ser Ser Arg Thr Ser  Tyr Val Ser 
    2285                 2290                 2295             


Ser Leu  Thr Ser Gln Ser His  Pro Leu Arg Arg Val  Pro Asn Gly 
    2300                 2305                 2310             


Tyr His  Cys Thr Leu Gly Leu  Ser Ser Gly Gly Arg  Ala Arg His 
    2315                 2320                 2325             


Ser Tyr  His His Pro Asp Gln  Asp His Trp Cys 
    2330                 2335                 


<210>  212
<211>  2138
<212>  PRT
<213>  Homo sapiens

<400>  212

Met Val Asn Glu Asn Thr Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser Thr Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Thr Thr 
                85                  90                  95      


Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Thr 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Thr Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Thr Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Thr Glu Val Gln Asp Thr Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Thr Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr Ile Leu Val Glu Thr 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Thr Arg Arg Ser Thr 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Thr Val Phe Gln Ile Leu Thr 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Thr Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Thr Thr Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Thr Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Thr Thr Ile Phe 
    930                 935                 940                 


Thr Ile Glu Ile Ala Leu Lys Met Thr Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Thr Ile Gly  Asn Ile Val Ile Val  Thr Thr Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Thr Cys Ser Asp  Ser Ser Lys Gln Thr  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Thr  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Thr  Val Ser Thr 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Thr Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Thr Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Thr Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Thr 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Thr Gly  Leu Phe Thr 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys His Tyr 
    1265                 1270                 1275             


Phe Cys  Asp Ala Trp Asn Thr  Phe Asp Ala Leu Ile  Val Val Gly 
    1280                 1285                 1290             


Ser Ile  Val Asp Ile Ala Ile  Thr Glu Val Asn Pro  Ala Glu His 
    1295                 1300                 1305             


Thr Gln  Cys Ser Pro Ser Met  Asn Ala Glu Glu Asn  Ser Arg Ile 
    1310                 1315                 1320             


Ser Ile  Thr Phe Phe Arg Leu  Phe Arg Val Met Arg  Leu Val Lys 
    1325                 1330                 1335             


Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Thr Leu Leu  Trp Thr Phe 
    1340                 1345                 1350             


Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Val 
    1355                 1360                 1365             


Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly Met Gln  Val Phe Gly 
    1370                 1375                 1380             


Lys Ile  Ala Leu Asn Asp Thr  Thr Glu Ile Asn Arg  Asn Asn Asn 
    1385                 1390                 1395             


Phe Gln  Thr Phe Pro Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala 
    1400                 1405                 1410             


Thr Gly  Glu Ala Trp Gln Asp  Ile Met Leu Ala Cys  Met Pro Gly 
    1415                 1420                 1425             


Lys Lys  Cys Ala Pro Glu Ser  Glu Pro Ser Asn Ser  Thr Glu Gly 
    1430                 1435                 1440             


Glu Thr  Pro Cys Gly Ser Ser  Phe Ala Val Phe Tyr  Phe Ile Ser 
    1445                 1450                 1455             


Phe Tyr  Met Leu Cys Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala 
    1460                 1465                 1470             


Val Ile  Met Asp Asn Phe Asp  Tyr Leu Thr Arg Asp  Trp Ser Ile 
    1475                 1480                 1485             


Leu Gly  Pro His His Leu Asp  Glu Phe Lys Arg Ile  Trp Ala Glu 
    1490                 1495                 1500             


Tyr Asp  Pro Glu Ala Lys Gly  Arg Ile Lys His Leu  Asp Val Val 
    1505                 1510                 1515             


Thr Leu  Leu Arg Arg Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu 
    1520                 1525                 1530             


Cys Pro  His Arg Val Ala Cys  Lys Arg Leu Val Ser  Met Asn Met 
    1535                 1540                 1545             


Pro Leu  Asn Ser Asp Gly Thr  Val Met Phe Asn Ala  Thr Leu Phe 
    1550                 1555                 1560             


Ala Leu  Val Arg Thr Ala Leu  Arg Ile Lys Thr Glu  Gly Asn Leu 
    1565                 1570                 1575             


Glu Gln  Ala Asn Glu Glu Leu  Arg Ala Ile Ile Lys  Lys Ile Trp 
    1580                 1585                 1590             


Lys Arg  Thr Ser Met Lys Leu  Leu Asp Gln Val Val  Pro Pro Ala 
    1595                 1600                 1605             


Gly Asp  Asp Glu Val Thr Val  Gly Lys Phe Tyr Ala  Thr Phe Leu 
    1610                 1615                 1620             


Ile Gln  Glu Tyr Phe Arg Lys  Phe Lys Lys Arg Lys  Glu Gln Gly 
    1625                 1630                 1635             


Leu Val  Gly Lys Pro Ser Gln  Arg Asn Ala Leu Ser  Leu Gln Ala 
    1640                 1645                 1650             


Gly Leu  Arg Thr Leu His Asp  Ile Gly Pro Glu Ile  Arg Arg Ala 
    1655                 1660                 1665             


Ile Ser  Gly Asp Leu Thr Ala  Glu Glu Glu Leu Asp  Lys Ala Met 
    1670                 1675                 1680             


Lys Glu  Ala Val Ser Ala Ala  Ser Glu Asp Asp Ile  Phe Arg Arg 
    1685                 1690                 1695             


Ala Gly  Gly Leu Phe Gly Asn  His Val Ser Tyr Tyr  Gln Ser Asp 
    1700                 1705                 1710             


Gly Arg  Ser Ala Phe Pro Gln  Thr Phe Thr Thr Gln  Arg Pro Leu 
    1715                 1720                 1725             


His Ile  Asn Lys Ala Gly Ser  Ser Gln Gly Asp Thr  Glu Ser Pro 
    1730                 1735                 1740             


Ser His  Glu Lys Leu Val Asp  Ser Thr Phe Thr Pro  Ser Ser Tyr 
    1745                 1750                 1755             


Ser Ser  Thr Gly Ser Asn Ala  Asn Ile Asn Asn Ala  Asn Asn Thr 
    1760                 1765                 1770             


Ala Leu  Gly Arg Leu Pro Arg  Pro Ala Gly Tyr Pro  Ser Thr Val 
    1775                 1780                 1785             


Ser Thr  Val Glu Gly His Gly  Pro Pro Leu Ser Pro  Ala Ile Arg 
    1790                 1795                 1800             


Val Gln  Glu Val Ala Trp Lys  Leu Ser Ser Asn Arg  Cys His Ser 
    1805                 1810                 1815             


Arg Glu  Ser Gln Ala Ala Met  Ala Gly Gln Glu Glu  Thr Ser Gln 
    1820                 1825                 1830             


Asp Glu  Thr Tyr Glu Val Lys  Met Asn His Asp Thr  Glu Ala Cys 
    1835                 1840                 1845             


Ser Glu  Pro Ser Leu Leu Ser  Thr Glu Met Leu Ser  Tyr Gln Asp 
    1850                 1855                 1860             


Asp Glu  Asn Arg Gln Leu Thr  Leu Pro Glu Glu Asp  Lys Arg Asp 
    1865                 1870                 1875             


Ile Arg  Gln Ser Pro Lys Arg  Gly Phe Leu Arg Ser  Ala Ser Leu 
    1880                 1885                 1890             


Gly Arg  Arg Ala Ser Phe His  Leu Glu Cys Leu Lys  Arg Gln Lys 
    1895                 1900                 1905             


Asp Arg  Gly Gly Asp Ile Ser  Gln Lys Thr Val Leu  Pro Leu His 
    1910                 1915                 1920             


Leu Val  His His Gln Ala Leu  Ala Val Ala Gly Leu  Ser Pro Leu 
    1925                 1930                 1935             


Leu Gln  Arg Ser His Ser Pro  Ala Ser Phe Pro Arg  Pro Phe Ala 
    1940                 1945                 1950             


Thr Pro  Pro Ala Thr Pro Gly  Ser Arg Gly Trp Pro  Pro Gln Pro 
    1955                 1960                 1965             


Val Pro  Thr Leu Arg Leu Glu  Gly Val Glu Ser Ser  Glu Lys Leu 
    1970                 1975                 1980             


Asn Ser  Ser Phe Pro Ser Ile  His Cys Gly Ser Trp  Ala Glu Thr 
    1985                 1990                 1995             


Thr Pro  Gly Gly Gly Gly Ser  Ser Ala Ala Arg Arg  Val Arg Pro 
    2000                 2005                 2010             


Val Ser  Leu Met Val Pro Ser  Gln Ala Gly Ala Pro  Gly Arg Gln 
    2015                 2020                 2025             


Phe His  Gly Ser Ala Ser Ser  Leu Val Glu Ala Val  Leu Ile Ser 
    2030                 2035                 2040             


Glu Gly  Leu Gly Gln Phe Ala  Gln Asp Pro Lys Phe  Ile Glu Val 
    2045                 2050                 2055             


Thr Thr  Gln Glu Leu Ala Asp  Ala Cys Asp Met Thr  Ile Glu Glu 
    2060                 2065                 2070             


Met Glu  Ser Ala Ala Asp Asn  Ile Leu Ser Gly Gly  Ala Pro Gln 
    2075                 2080                 2085             


Ser Pro  Asn Gly Ala Leu Leu  Pro Phe Val Asn Cys  Arg Asp Ala 
    2090                 2095                 2100             


Gly Gln  Asp Arg Ala Gly Gly  Glu Glu Asp Ala Gly  Cys Val Arg 
    2105                 2110                 2115             


Ala Arg  Gly Arg Pro Ser Glu  Glu Glu Leu Gln Asp  Ser Arg Val 
    2120                 2125                 2130             


Tyr Val  Ser Ser Leu 
    2135             


<210>  213
<211>  2181
<212>  PRT
<213>  Homo sapiens

<400>  213

Met Met Met Met Met Met Met Lys Lys Met Gln His Gln Arg Gln Gln 
1               5                   10                  15      


Gln Ala Asp His Ala Asn Glu Ala Asn Tyr Ala Arg Gly Thr Arg Leu 
            20                  25                  30          


Pro Leu Ser Gly Glu Gly Pro Thr Ser Gln Pro Asn Ser Ser Lys Gln 
        35                  40                  45              


Thr Val Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys 
    50                  55                  60                  


Ala Ala Gln Thr Met Ser Thr Ser Ala Pro Pro Pro Val Gly Ser Leu 
65                  70                  75                  80  


Ser Gln Arg Lys Arg Gln Gln Tyr Ala Lys Ser Lys Lys Gln Gly Asn 
                85                  90                  95      


Ser Ser Asn Ser Arg Pro Ala Arg Ala Leu Phe Cys Leu Ser Leu Asn 
            100                 105                 110         


Asn Pro Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe 
        115                 120                 125             


Asp Ile Phe Ile Leu Leu Ala Ile Phe Ala Asn Cys Val Ala Leu Ala 
    130                 135                 140                 


Ile Tyr Ile Pro Phe Pro Glu Asp Asp Ser Asn Ser Thr Asn His Asn 
145                 150                 155                 160 


Leu Glu Lys Val Glu Tyr Ala Phe Leu Ile Ile Phe Thr Val Glu Thr 
                165                 170                 175     


Phe Leu Lys Ile Ile Ala Tyr Gly Leu Leu Leu His Pro Asn Ala Tyr 
            180                 185                 190         


Val Arg Asn Gly Trp Asn Leu Leu Asp Phe Val Ile Val Ile Val Gly 
        195                 200                 205             


Leu Phe Ser Val Ile Leu Glu Gln Leu Thr Lys Glu Thr Glu Gly Gly 
    210                 215                 220                 


Asn His Ser Ser Gly Lys Ser Gly Gly Phe Asp Val Lys Ala Leu Arg 
225                 230                 235                 240 


Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser 
                245                 250                 255     


Leu Gln Val Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu 
            260                 265                 270         


His Ile Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile 
        275                 280                 285             


Gly Leu Glu Leu Phe Ile Gly Lys Met His Lys Thr Cys Phe Phe Ala 
    290                 295                 300                 


Asp Ser Asp Ile Val Ala Glu Glu Asp Pro Ala Pro Cys Ala Phe Ser 
305                 310                 315                 320 


Gly Asn Gly Arg Gln Cys Thr Ala Asn Gly Thr Glu Cys Arg Ser Gly 
                325                 330                 335     


Trp Val Gly Pro Asn Gly Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe 
            340                 345                 350         


Ala Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp 
        355                 360                 365             


Val Leu Tyr Trp Val Asn Asp Ala Ile Gly Trp Glu Trp Pro Trp Val 
    370                 375                 380                 


Tyr Phe Val Ser Leu Ile Ile Leu Gly Ser Phe Phe Val Leu Asn Leu 
385                 390                 395                 400 


Val Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala 
                405                 410                 415     


Lys Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu 
            420                 425                 430         


Glu Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile 
        435                 440                 445             


Asp Pro Glu Asn Glu Glu Glu Gly Gly Glu Glu Gly Lys Arg Asn Thr 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ser 
465                 470                 475                 480 


Gly Glu Gly Glu Asn Arg Gly Cys Cys Gly Ser Leu Trp Cys Trp Trp 
                485                 490                 495     


Arg Arg Arg Gly Ala Ala Lys Ala Gly Pro Ser Gly Cys Arg Arg Trp 
            500                 505                 510         


Gly Gln Ala Ile Ser Lys Ser Lys Leu Ser Arg Arg Trp Arg Arg Trp 
        515                 520                 525             


Asn Arg Phe Asn Arg Arg Arg Cys Arg Ala Ala Val Lys Ser Val Thr 
    530                 535                 540                 


Phe Tyr Trp Leu Val Ile Val Leu Val Phe Leu Asn Thr Leu Thr Ile 
545                 550                 555                 560 


Ser Ser Glu His Tyr Asn Gln Pro Asp Trp Leu Thr Gln Ile Gln Asp 
                565                 570                 575     


Ile Ala Asn Lys Val Leu Leu Ala Leu Phe Thr Cys Glu Met Leu Val 
            580                 585                 590         


Lys Met Tyr Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn 
        595                 600                 605             


Arg Phe Asp Cys Phe Val Val Cys Gly Gly Ile Thr Glu Thr Ile Leu 
    610                 615                 620                 


Val Glu Leu Glu Ile Met Ser Pro Leu Gly Ile Ser Val Phe Arg Cys 
625                 630                 635                 640 


Val Arg Leu Leu Arg Ile Phe Lys Val Thr Arg His Trp Thr Ser Leu 
                645                 650                 655     


Ser Asn Leu Val Ala Ser Leu Leu Asn Ser Met Lys Ser Ile Ala Ser 
            660                 665                 670         


Leu Leu Leu Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly 
        675                 680                 685             


Met Gln Leu Phe Gly Gly Lys Phe Asn Phe Asp Glu Thr Gln Thr Lys 
    690                 695                 700                 


Arg Ser Thr Phe Asp Asn Phe Pro Gln Ala Leu Leu Thr Val Phe Gln 
705                 710                 715                 720 


Ile Leu Thr Gly Glu Asp Trp Asn Ala Val Met Tyr Asp Gly Ile Met 
                725                 730                 735     


Ala Tyr Gly Gly Pro Ser Ser Ser Gly Met Ile Val Cys Ile Tyr Phe 
            740                 745                 750         


Ile Ile Leu Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu 
        755                 760                 765             


Ala Ile Ala Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Asn Thr Ala 
    770                 775                 780                 


Gln Lys Glu Glu Ala Glu Glu Lys Glu Arg Lys Lys Ile Ala Arg Lys 
785                 790                 795                 800 


Glu Ser Leu Glu Asn Lys Lys Asn Asn Lys Pro Glu Val Asn Gln Ile 
                805                 810                 815     


Ala Asn Ser Asp Asn Lys Val Thr Ile Asp Asp Tyr Arg Glu Glu Asp 
            820                 825                 830         


Glu Asp Lys Asp Pro Tyr Pro Pro Cys Asp Val Pro Val Gly Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Glu Asp Glu Pro Glu Val Pro Ala Gly Pro Arg 
    850                 855                 860                 


Pro Arg Arg Ile Ser Glu Leu Asn Met Lys Glu Lys Ile Ala Pro Ile 
865                 870                 875                 880 


Pro Glu Gly Ser Ala Phe Phe Ile Leu Ser Lys Thr Asn Pro Ile Arg 
                885                 890                 895     


Val Gly Cys His Lys Leu Ile Asn His His Ile Phe Thr Asn Leu Ile 
            900                 905                 910         


Leu Val Phe Ile Met Leu Ser Ser Ala Ala Leu Ala Ala Glu Asp Pro 
        915                 920                 925             


Ile Arg Ser His Ser Phe Arg Asn Thr Ile Leu Gly Tyr Phe Asp Tyr 
    930                 935                 940                 


Ala Phe Thr Ala Ile Phe Thr Val Glu Ile Leu Leu Lys Met Thr Thr 
945                 950                 955                 960 


Phe Gly Ala Phe Leu His Lys Gly Ala Phe Cys Arg Asn Tyr Phe Asn 
                965                 970                 975     


Leu Leu Asp Met Leu Val Val Gly Val Ser Leu Val Ser Phe Gly Ile 
            980                 985                 990         


Gln Ser Ser Ala Ile Ser Val Val  Lys Ile Leu Arg Val  Leu Arg Val 
        995                 1000                 1005             


Leu Arg  Pro Leu Arg Ala Ile  Asn Arg Ala Lys Gly  Leu Lys His 
    1010                 1015                 1020             


Val Val  Gln Cys Val Phe Val  Ala Ile Arg Thr Ile  Gly Asn Ile 
    1025                 1030                 1035             


Met Ile  Val Thr Thr Leu Leu  Gln Phe Met Phe Ala  Cys Ile Gly 
    1040                 1045                 1050             


Val Gln  Leu Phe Lys Gly Lys  Phe Tyr Arg Cys Thr  Asp Glu Ala 
    1055                 1060                 1065             


Lys Ser  Asn Pro Glu Glu Cys  Arg Gly Leu Phe Ile  Leu Tyr Lys 
    1070                 1075                 1080             


Asp Gly  Asp Val Asp Ser Pro  Val Val Arg Glu Arg  Ile Trp Gln 
    1085                 1090                 1095             


Asn Ser  Asp Phe Asn Phe Asp  Asn Val Leu Ser Ala  Met Met Ala 
    1100                 1105                 1110             


Leu Phe  Thr Val Ser Thr Phe  Glu Gly Trp Pro Ala  Leu Leu Tyr 
    1115                 1120                 1125             


Lys Ala  Ile Asp Ser Asn Gly  Glu Asn Ile Gly Pro  Ile Tyr Asn 
    1130                 1135                 1140             


His Arg  Val Glu Ile Ser Ile  Phe Phe Ile Ile Tyr  Ile Ile Ile 
    1145                 1150                 1155             


Val Ala  Phe Phe Met Met Asn  Ile Phe Val Gly Phe  Val Ile Val 
    1160                 1165                 1170             


Thr Phe  Gln Glu Gln Gly Glu  Lys Glu Tyr Lys Asn  Cys Glu Leu 
    1175                 1180                 1185             


Asp Lys  Asn Gln Arg Gln Cys  Val Glu Tyr Ala Leu  Lys Ala Arg 
    1190                 1195                 1200             


Pro Leu  Arg Arg Tyr Ile Pro  Lys Asn Pro Tyr Gln  Tyr Lys Phe 
    1205                 1210                 1215             


Trp Tyr  Val Val Asn Ser Ser  Pro Phe Glu Tyr Met  Met Phe Val 
    1220                 1225                 1230             


Leu Ile  Met Leu Asn Thr Leu  Cys Leu Ala Met Gln  His Tyr Glu 
    1235                 1240                 1245             


Gln Ser  Lys Met Phe Asn Asp  Ala Met Asp Ile Leu  Asn Met Val 
    1250                 1255                 1260             


Phe Thr  Gly Val Phe Thr Val  Glu Met Val Leu Lys  Val Ile Ala 
    1265                 1270                 1275             


Phe Lys  Pro Lys Gly Tyr Phe  Ser Asp Ala Trp Asn  Thr Phe Asp 
    1280                 1285                 1290             


Ser Leu  Ile Val Ile Gly Ser  Ile Ile Asp Val Ala  Leu Ser Glu 
    1295                 1300                 1305             


Ala Asp  Pro Thr Glu Ser Glu  Asn Val Pro Val Pro  Thr Ala Thr 
    1310                 1315                 1320             


Pro Gly  Asn Ser Glu Glu Ser  Asn Arg Ile Ser Ile  Thr Phe Phe 
    1325                 1330                 1335             


Arg Leu  Phe Arg Val Met Arg  Leu Val Lys Leu Leu  Ser Arg Gly 
    1340                 1345                 1350             


Glu Gly  Ile Arg Thr Leu Leu  Trp Thr Phe Ile Lys  Ser Phe Gln 
    1355                 1360                 1365             


Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Ala Met Leu  Phe Phe Ile 
    1370                 1375                 1380             


Tyr Ala  Val Ile Gly Met Gln  Met Phe Gly Lys Val  Ala Met Arg 
    1385                 1390                 1395             


Asp Asn  Asn Gln Ile Asn Arg  Asn Asn Asn Phe Gln  Thr Phe Pro 
    1400                 1405                 1410             


Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala Thr Gly  Glu Ala Trp 
    1415                 1420                 1425             


Gln Glu  Ile Met Leu Ala Cys  Leu Pro Gly Lys Leu  Cys Asp Pro 
    1430                 1435                 1440             


Glu Ser  Asp Tyr Asn Pro Gly  Glu Glu Tyr Thr Cys  Gly Ser Asn 
    1445                 1450                 1455             


Phe Ala  Ile Val Tyr Phe Ile  Ser Phe Tyr Met Leu  Cys Ala Phe 
    1460                 1465                 1470             


Leu Ile  Ile Asn Leu Phe Val  Ala Val Ile Met Asp  Asn Phe Asp 
    1475                 1480                 1485             


Tyr Leu  Thr Arg Asp Trp Ser  Ile Leu Gly Pro His  His Leu Asp 
    1490                 1495                 1500             


Glu Phe  Lys Arg Ile Trp Ser  Glu Tyr Asp Pro Glu  Ala Lys Gly 
    1505                 1510                 1515             


Arg Ile  Lys His Leu Asp Val  Val Thr Leu Leu Arg  Arg Ile Gln 
    1520                 1525                 1530             


Pro Pro  Leu Gly Phe Gly Lys  Leu Cys Pro His Arg  Val Ala Cys 
    1535                 1540                 1545             


Lys Arg  Leu Val Ala Met Asn  Met Pro Leu Asn Ser  Asp Gly Thr 
    1550                 1555                 1560             


Val Met  Phe Asn Ala Thr Leu  Phe Ala Leu Val Arg  Thr Ala Leu 
    1565                 1570                 1575             


Lys Ile  Lys Thr Glu Gly Asn  Leu Glu Gln Ala Asn  Glu Glu Leu 
    1580                 1585                 1590             


Arg Ala  Val Ile Lys Lys Ile  Trp Lys Lys Thr Ser  Met Lys Leu 
    1595                 1600                 1605             


Leu Asp  Gln Val Val Pro Pro  Ala Gly Asp Asp Glu  Val Thr Val 
    1610                 1615                 1620             


Gly Lys  Phe Tyr Ala Thr Phe  Leu Ile Gln Asp Tyr  Phe Arg Lys 
    1625                 1630                 1635             


Phe Lys  Lys Arg Lys Glu Gln  Gly Leu Val Gly Lys  Tyr Pro Ala 
    1640                 1645                 1650             


Lys Asn  Thr Thr Ile Ala Leu  Gln Ala Gly Leu Arg  Thr Leu His 
    1655                 1660                 1665             


Asp Ile  Gly Pro Glu Ile Arg  Arg Ala Ile Ser Cys  Asp Leu Gln 
    1670                 1675                 1680             


Asp Asp  Glu Pro Glu Glu Thr  Lys Arg Glu Glu Glu  Asp Asp Val 
    1685                 1690                 1695             


Phe Lys  Arg Asn Gly Ala Leu  Leu Gly Asn His Val  Asn His Val 
    1700                 1705                 1710             


Asn Ser  Asp Arg Arg Asp Ser  Leu Gln Gln Thr Asn  Thr Thr His 
    1715                 1720                 1725             


Arg Pro  Leu His Val Gln Arg  Pro Ser Ile Pro Pro  Ala Ser Asp 
    1730                 1735                 1740             


Thr Glu  Lys Pro Leu Phe Pro  Pro Ala Gly Asn Ser  Val Cys His 
    1745                 1750                 1755             


Asn His  His Asn His Asn Ser  Ile Gly Lys Gln Val  Pro Thr Ser 
    1760                 1765                 1770             


Thr Asn  Ala Asn Leu Asn Asn  Ala Asn Met Ser Lys  Ala Ala His 
    1775                 1780                 1785             


Gly Lys  Arg Pro Ser Ile Gly  Asn Leu Glu His Val  Ser Glu Asn 
    1790                 1795                 1800             


Gly His  His Ser Ser His Lys  His Asp Arg Glu Pro  Gln Arg Arg 
    1805                 1810                 1815             


Ser Ser  Val Lys Arg Thr Arg  Tyr Tyr Glu Thr Tyr  Ile Arg Ser 
    1820                 1825                 1830             


Asp Ser  Gly Asp Glu Gln Leu  Pro Thr Ile Cys Arg  Glu Asp Pro 
    1835                 1840                 1845             


Glu Ile  His Gly Tyr Phe Arg  Asp Pro His Cys Leu  Gly Glu Gln 
    1850                 1855                 1860             


Glu Tyr  Phe Ser Ser Glu Glu  Cys Tyr Glu Asp Asp  Ser Ser Pro 
    1865                 1870                 1875             


Thr Trp  Ser Arg Gln Asn Tyr  Gly Tyr Tyr Ser Arg  Tyr Pro Gly 
    1880                 1885                 1890             


Arg Asn  Ile Asp Ser Glu Arg  Pro Arg Gly Tyr His  His Pro Gln 
    1895                 1900                 1905             


Gly Phe  Leu Glu Asp Asp Asp  Ser Pro Val Cys Tyr  Asp Ser Arg 
    1910                 1915                 1920             


Arg Ser  Pro Arg Arg Arg Leu  Leu Pro Pro Thr Pro  Ala Ser His 
    1925                 1930                 1935             


Arg Arg  Ser Ser Phe Asn Phe  Glu Cys Leu Arg Arg  Gln Ser Ser 
    1940                 1945                 1950             


Gln Glu  Glu Val Pro Ser Ser  Pro Ile Phe Pro His  Arg Thr Ala 
    1955                 1960                 1965             


Leu Pro  Leu His Leu Met Gln  Gln Gln Ile Met Ala  Val Ala Gly 
    1970                 1975                 1980             


Leu Asp  Ser Ser Lys Ala Gln  Lys Tyr Ser Pro Ser  His Ser Thr 
    1985                 1990                 1995             


Arg Ser  Trp Ala Thr Pro Pro  Ala Thr Pro Pro Tyr  Arg Asp Trp 
    2000                 2005                 2010             


Thr Pro  Cys Tyr Thr Pro Leu  Ile Gln Val Glu Gln  Ser Glu Ala 
    2015                 2020                 2025             


Leu Asp  Gln Val Asn Gly Ser  Leu Pro Ser Leu His  Arg Ser Ser 
    2030                 2035                 2040             


Trp Tyr  Thr Asp Glu Pro Asp  Ile Ser Tyr Arg Thr  Phe Thr Pro 
    2045                 2050                 2055             


Ala Ser  Leu Thr Val Pro Ser  Ser Phe Arg Asn Lys  Asn Ser Asp 
    2060                 2065                 2070             


Lys Gln  Arg Ser Ala Asp Ser  Leu Val Glu Ala Val  Leu Ile Ser 
    2075                 2080                 2085             


Glu Gly  Leu Gly Arg Tyr Ala  Arg Asp Pro Lys Phe  Val Ser Ala 
    2090                 2095                 2100             


Thr Lys  His Glu Ile Ala Asp  Ala Cys Asp Leu Thr  Ile Asp Glu 
    2105                 2110                 2115             


Met Glu  Ser Ala Ala Ser Thr  Leu Leu Asn Gly Asn  Val Arg Pro 
    2120                 2125                 2130             


Arg Ala  Asn Gly Asp Val Gly  Pro Leu Ser His Arg  Gln Asp Tyr 
    2135                 2140                 2145             


Glu Leu  Gln Asp Phe Gly Pro  Gly Tyr Ser Asp Glu  Glu Pro Asp 
    2150                 2155                 2160             


Pro Gly  Arg Asp Glu Glu Asp  Leu Ala Asp Glu Met  Ile Cys Ile 
    2165                 2170                 2175             


Thr Thr  Leu 
    2180     


<210>  214
<211>  2270
<212>  PRT
<213>  Homo sapiens

<400>  214

Met Ala Arg Phe Gly Glu Ala Val Val Ala Arg Pro Gly Ser Gly Asp 
1               5                   10                  15      


Gly Asp Ser Asp Gln Ser Arg Asn Arg Gln Gly Thr Pro Val Pro Ala 
            20                  25                  30          


Ser Gly Gln Ala Ala Ala Tyr Lys Gln Thr Lys Ala Gln Arg Ala Arg 
        35                  40                  45              


Thr Met Ala Leu Tyr Asn Pro Ile Pro Val Arg Gln Asn Cys Phe Thr 
    50                  55                  60                  


Val Asn Arg Ser Leu Phe Ile Phe Gly Glu Asp Asn Ile Val Arg Lys 
65                  70                  75                  80  


Tyr Ala Lys Lys Leu Ile Asp Trp Pro Pro Phe Glu Tyr Met Ile Leu 
                85                  90                  95      


Ala Thr Ile Ile Ala Asn Cys Ile Val Leu Ala Leu Glu Gln His Leu 
            100                 105                 110         


Pro Glu Asp Asp Lys Thr Pro Met Ser Arg Arg Leu Glu Lys Thr Glu 
        115                 120                 125             


Pro Tyr Phe Ile Gly Ile Phe Cys Phe Glu Ala Gly Ile Lys Ile Val 
    130                 135                 140                 


Ala Leu Gly Phe Ile Phe His Lys Gly Ser Tyr Leu Arg Asn Gly Trp 
145                 150                 155                 160 


Asn Val Met Asp Phe Ile Val Val Leu Ser Gly Ile Leu Ala Thr Ala 
                165                 170                 175     


Gly Thr His Phe Asn Thr His Val Asp Leu Arg Thr Leu Arg Ala Val 
            180                 185                 190         


Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly Ile Pro Ser Leu Gln 
        195                 200                 205             


Ile Val Leu Lys Ser Ile Met Lys Ala Met Val Pro Leu Leu Gln Ile 
    210                 215                 220                 


Gly Leu Leu Leu Phe Phe Ala Ile Leu Met Phe Ala Ile Ile Gly Leu 
225                 230                 235                 240 


Glu Phe Tyr Ser Gly Lys Leu His Arg Ala Cys Phe Met Asn Asn Ser 
                245                 250                 255     


Gly Ile Leu Glu Gly Phe Asp Pro Pro His Pro Cys Gly Val Gln Gly 
            260                 265                 270         


Cys Pro Ala Gly Tyr Glu Cys Lys Asp Trp Ile Gly Pro Asn Asp Gly 
        275                 280                 285             


Ile Thr Gln Phe Asp Asn Ile Leu Phe Ala Val Leu Thr Val Phe Gln 
    290                 295                 300                 


Cys Ile Thr Met Glu Gly Trp Thr Thr Val Leu Tyr Asn Thr Asn Asp 
305                 310                 315                 320 


Ala Leu Gly Ala Thr Trp Asn Trp Leu Tyr Phe Ile Pro Leu Ile Ile 
                325                 330                 335     


Ile Gly Ser Phe Phe Val Leu Asn Leu Val Leu Gly Val Leu Ser Gly 
            340                 345                 350         


Glu Phe Ala Lys Glu Arg Glu Arg Val Glu Asn Arg Arg Ala Phe Met 
        355                 360                 365             


Lys Leu Arg Arg Gln Gln Gln Ile Glu Arg Glu Leu Asn Gly Tyr Arg 
    370                 375                 380                 


Ala Trp Ile Asp Lys Ala Glu Glu Val Met Leu Ala Glu Glu Asn Lys 
385                 390                 395                 400 


Asn Ala Gly Thr Ser Ala Leu Glu Val Leu Arg Arg Ala Thr Ile Lys 
                405                 410                 415     


Arg Ser Arg Thr Glu Ala Met Thr Arg Asp Ser Ser Asp Glu His Cys 
            420                 425                 430         


Val Asp Ile Ser Ser Val Gly Thr Pro Leu Ala Arg Ala Ser Ile Lys 
        435                 440                 445             


Ser Ala Lys Val Asp Gly Val Ser Tyr Phe Arg His Lys Glu Arg Leu 
    450                 455                 460                 


Leu Arg Ile Ser Ile Arg His Met Val Lys Ser Gln Val Phe Tyr Trp 
465                 470                 475                 480 


Ile Val Leu Ser Leu Val Ala Leu Asn Thr Ala Cys Val Ala Ile Val 
                485                 490                 495     


His His Asn Gln Pro Gln Trp Leu Thr His Leu Leu Tyr Tyr Ala Glu 
            500                 505                 510         


Phe Leu Phe Leu Gly Leu Phe Leu Leu Glu Met Ser Leu Lys Met Tyr 
        515                 520                 525             


Gly Met Gly Pro Arg Leu Tyr Phe His Ser Ser Phe Asn Cys Phe Asp 
    530                 535                 540                 


Phe Gly Val Thr Val Gly Ser Ile Phe Glu Val Val Trp Ala Ile Phe 
545                 550                 555                 560 


Arg Pro Gly Thr Ser Phe Gly Ile Ser Val Leu Arg Ala Leu Arg Leu 
                565                 570                 575     


Leu Arg Ile Phe Lys Ile Thr Lys Tyr Trp Ala Ser Leu Arg Asn Leu 
            580                 585                 590         


Val Val Ser Leu Met Ser Ser Met Lys Ser Ile Ile Ser Leu Leu Phe 
        595                 600                 605             


Leu Leu Phe Leu Phe Ile Val Val Phe Ala Leu Leu Gly Met Gln Leu 
    610                 615                 620                 


Phe Gly Gly Arg Phe Asn Phe Asn Asp Gly Thr Pro Ser Ala Asn Phe 
625                 630                 635                 640 


Asp Thr Phe Pro Ala Ala Ile Met Thr Val Phe Gln Ile Leu Thr Gly 
                645                 650                 655     


Glu Asp Trp Asn Glu Val Met Tyr Asn Gly Ile Arg Ser Gln Gly Gly 
            660                 665                 670         


Val Ser Ser Gly Met Trp Ser Ala Ile Tyr Phe Ile Val Leu Thr Leu 
        675                 680                 685             


Phe Gly Asn Tyr Thr Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp 
    690                 695                 700                 


Asn Leu Ala Asn Ala Gln Glu Leu Thr Lys Asp Glu Gln Glu Glu Glu 
705                 710                 715                 720 


Glu Ala Phe Asn Gln Lys His Ala Leu Gln Lys Ala Lys Glu Val Ser 
                725                 730                 735     


Pro Met Ser Ala Pro Asn Met Pro Ser Ile Glu Arg Asp Arg Arg Arg 
            740                 745                 750         


Arg His His Met Ser Met Trp Glu Pro Arg Ser Ser His Leu Arg Glu 
        755                 760                 765             


Arg Arg Arg Arg His His Met Ser Val Trp Glu Gln Arg Thr Ser Gln 
    770                 775                 780                 


Leu Arg Lys His Met Gln Met Ser Ser Gln Glu Ala Leu Asn Arg Glu 
785                 790                 795                 800 


Glu Ala Pro Thr Met Asn Pro Leu Asn Pro Leu Asn Pro Leu Ser Ser 
                805                 810                 815     


Leu Asn Pro Leu Asn Ala His Pro Ser Leu Tyr Arg Arg Pro Arg Ala 
            820                 825                 830         


Ile Glu Gly Leu Ala Leu Gly Leu Ala Leu Glu Lys Phe Glu Glu Glu 
        835                 840                 845             


Arg Ile Ser Arg Gly Gly Ser Leu Lys Gly Asp Gly Gly Asp Arg Ser 
    850                 855                 860                 


Ser Ala Leu Asp Asn Gln Arg Thr Pro Leu Ser Leu Gly Gln Arg Glu 
865                 870                 875                 880 


Pro Pro Trp Leu Ala Arg Pro Cys His Gly Asn Cys Asp Pro Thr Gln 
                885                 890                 895     


Gln Glu Ala Gly Gly Gly Glu Ala Val Val Thr Phe Glu Asp Arg Ala 
            900                 905                 910         


Arg His Arg Gln Ser Gln Arg Arg Ser Arg His Arg Arg Val Arg Thr 
        915                 920                 925             


Glu Gly Lys Glu Ser Ser Ser Ala Ser Arg Ser Arg Ser Ala Ser Gln 
    930                 935                 940                 


Glu Arg Ser Leu Asp Glu Ala Met Pro Thr Glu Gly Glu Lys Asp His 
945                 950                 955                 960 


Glu Leu Arg Gly Asn His Gly Ala Lys Glu Pro Thr Ile Gln Glu Glu 
                965                 970                 975     


Arg Ala Gln Asp Leu Arg Arg Thr Asn Ser Leu Met Val Ser Arg Gly 
            980                 985                 990         


Ser Gly Leu Ala Gly Gly Leu Asp  Glu Ala Asp Thr Pro  Leu Val Leu 
        995                 1000                 1005             


Pro His  Pro Glu Leu Glu Val  Gly Lys His Val Val  Leu Thr Glu 
    1010                 1015                 1020             


Gln Glu  Pro Glu Gly Ser Ser  Glu Gln Ala Leu Leu  Gly Asn Val 
    1025                 1030                 1035             


Gln Leu  Asp Met Gly Arg Val  Ile Ser Gln Ser Glu  Pro Asp Leu 
    1040                 1045                 1050             


Ser Cys  Ile Thr Ala Asn Thr  Asp Lys Ala Thr Thr  Glu Ser Thr 
    1055                 1060                 1065             


Ser Val  Thr Val Ala Ile Pro  Asp Val Asp Pro Leu  Val Asp Ser 
    1070                 1075                 1080             


Thr Val  Val His Ile Ser Asn  Lys Thr Asp Gly Glu  Ala Ser Pro 
    1085                 1090                 1095             


Leu Lys  Glu Ala Glu Ile Arg  Glu Asp Glu Glu Glu  Val Glu Lys 
    1100                 1105                 1110             


Lys Lys  Gln Lys Lys Glu Lys  Arg Glu Thr Gly Lys  Ala Met Val 
    1115                 1120                 1125             


Pro His  Ser Ser Met Phe Ile  Phe Ser Thr Thr Asn  Pro Ile Arg 
    1130                 1135                 1140             


Arg Ala  Cys His Tyr Ile Val  Asn Leu Arg Tyr Phe  Glu Met Cys 
    1145                 1150                 1155             


Ile Leu  Leu Val Ile Ala Ala  Ser Ser Ile Ala Leu  Ala Ala Glu 
    1160                 1165                 1170             


Asp Pro  Val Leu Thr Asn Ser  Glu Arg Asn Lys Val  Leu Arg Tyr 
    1175                 1180                 1185             


Phe Asp  Tyr Val Phe Thr Gly  Val Phe Thr Phe Glu  Met Val Ile 
    1190                 1195                 1200             


Lys Met  Ile Asp Gln Gly Leu  Ile Leu Gln Asp Gly  Ser Tyr Phe 
    1205                 1210                 1215             


Arg Asp  Leu Trp Asn Ile Leu  Asp Phe Val Val Val  Val Gly Ala 
    1220                 1225                 1230             


Leu Val  Ala Phe Ala Leu Ala  Asn Ala Leu Gly Thr  Asn Lys Gly 
    1235                 1240                 1245             


Arg Asp  Ile Lys Thr Ile Lys  Ser Leu Arg Val Leu  Arg Val Leu 
    1250                 1255                 1260             


Arg Pro  Leu Lys Thr Ile Lys  Arg Leu Pro Lys Leu  Lys Ala Val 
    1265                 1270                 1275             


Phe Asp  Cys Val Val Thr Ser  Leu Lys Asn Val Phe  Asn Ile Leu 
    1280                 1285                 1290             


Ile Val  Tyr Lys Leu Phe Met  Phe Ile Phe Ala Val  Ile Ala Val 
    1295                 1300                 1305             


Gln Leu  Phe Lys Gly Lys Phe  Phe Tyr Cys Thr Asp  Ser Ser Lys 
    1310                 1315                 1320             


Asp Thr  Glu Lys Glu Cys Ile  Gly Asn Tyr Val Asp  His Glu Lys 
    1325                 1330                 1335             


Asn Lys  Met Glu Val Lys Gly  Arg Glu Trp Lys Arg  His Glu Phe 
    1340                 1345                 1350             


His Tyr  Asp Asn Ile Ile Trp  Ala Leu Leu Thr Leu  Phe Thr Val 
    1355                 1360                 1365             


Ser Thr  Gly Glu Gly Trp Pro  Gln Val Leu Gln His  Ser Val Asp 
    1370                 1375                 1380             


Val Thr  Glu Glu Asp Arg Gly  Pro Ser Arg Ser Asn  Arg Met Glu 
    1385                 1390                 1395             


Met Ser  Ile Phe Tyr Val Val  Tyr Phe Val Val Phe  Pro Phe Phe 
    1400                 1405                 1410             


Phe Val  Asn Ile Phe Val Ala  Leu Ile Ile Ile Thr  Phe Gln Glu 
    1415                 1420                 1425             


Gln Gly  Asp Lys Met Met Glu  Glu Cys Ser Leu Glu  Lys Asn Glu 
    1430                 1435                 1440             


Arg Ala  Cys Ile Asp Phe Ala  Ile Ser Ala Lys Pro  Leu Thr Arg 
    1445                 1450                 1455             


Tyr Met  Pro Gln Asn Arg His  Thr Phe Gln Tyr Arg  Val Trp His 
    1460                 1465                 1470             


Phe Val  Val Ser Pro Ser Phe  Glu Tyr Thr Ile Met  Ala Met Ile 
    1475                 1480                 1485             


Ala Leu  Asn Thr Val Val Leu  Met Met Lys Tyr Tyr  Ser Ala Pro 
    1490                 1495                 1500             


Cys Thr  Tyr Glu Leu Ala Leu  Lys Tyr Leu Asn Ile  Ala Phe Thr 
    1505                 1510                 1515             


Met Val  Phe Ser Leu Glu Cys  Val Leu Lys Val Ile  Ala Phe Gly 
    1520                 1525                 1530             


Phe Leu  Asn Tyr Phe Arg Asp  Thr Trp Asn Ile Phe  Asp Phe Ile 
    1535                 1540                 1545             


Thr Val  Ile Gly Ser Ile Thr  Glu Ile Ile Leu Thr  Asp Ser Lys 
    1550                 1555                 1560             


Leu Val  Asn Thr Ser Gly Phe  Asn Met Ser Phe Leu  Lys Leu Phe 
    1565                 1570                 1575             


Arg Ala  Ala Arg Leu Ile Lys  Leu Leu Arg Gln Gly  Tyr Thr Ile 
    1580                 1585                 1590             


Arg Ile  Leu Leu Trp Thr Phe  Val Gln Ser Phe Lys  Ala Leu Pro 
    1595                 1600                 1605             


Tyr Val  Cys Leu Leu Ile Ala  Met Leu Phe Phe Ile  Tyr Ala Ile 
    1610                 1615                 1620             


Ile Gly  Met Gln Val Phe Gly  Asn Ile Lys Leu Asp  Glu Glu Ser 
    1625                 1630                 1635             


His Ile  Asn Arg His Asn Asn  Phe Arg Ser Phe Phe  Gly Ser Leu 
    1640                 1645                 1650             


Met Leu  Leu Phe Arg Ser Ala  Thr Gly Glu Ala Trp  Gln Glu Ile 
    1655                 1660                 1665             


Met Leu  Ser Cys Leu Gly Glu  Lys Gly Cys Glu Pro  Asp Thr Thr 
    1670                 1675                 1680             


Ala Pro  Ser Gly Gln Asn Glu  Asn Glu Arg Cys Gly  Thr Asp Leu 
    1685                 1690                 1695             


Ala Tyr  Val Tyr Phe Val Ser  Phe Ile Phe Phe Cys  Ser Phe Leu 
    1700                 1705                 1710             


Met Leu  Asn Leu Phe Val Ala  Val Ile Met Asp Asn  Phe Glu Tyr 
    1715                 1720                 1725             


Leu Thr  Arg Asp Ser Ser Ile  Leu Gly Pro His His  Leu Asp Glu 
    1730                 1735                 1740             


Phe Val  Arg Val Trp Ala Glu  Tyr Asp Arg Ala Ala  Cys Gly Arg 
    1745                 1750                 1755             


Ile His  Tyr Thr Glu Met Tyr  Glu Met Leu Thr Leu  Met Ser Pro 
    1760                 1765                 1770             


Pro Leu  Gly Leu Gly Lys Arg  Cys Pro Ser Lys Val  Ala Tyr Lys 
    1775                 1780                 1785             


Arg Leu  Val Leu Met Asn Met  Pro Val Ala Glu Asp  Met Thr Val 
    1790                 1795                 1800             


His Phe  Thr Ser Thr Leu Met  Ala Leu Ile Arg Thr  Ala Leu Asp 
    1805                 1810                 1815             


Ile Lys  Ile Ala Lys Gly Gly  Ala Asp Arg Gln Gln  Leu Asp Ser 
    1820                 1825                 1830             


Glu Leu  Gln Lys Glu Thr Leu  Ala Ile Trp Pro His  Leu Ser Gln 
    1835                 1840                 1845             


Lys Met  Leu Asp Leu Leu Val  Pro Met Pro Lys Ala  Ser Asp Leu 
    1850                 1855                 1860             


Thr Val  Gly Lys Ile Tyr Ala  Ala Met Met Ile Met  Asp Tyr Tyr 
    1865                 1870                 1875             


Lys Gln  Ser Lys Val Lys Lys  Gln Arg Gln Gln Leu  Glu Glu Gln 
    1880                 1885                 1890             


Lys Asn  Ala Pro Met Phe Gln  Arg Met Glu Pro Ser  Ser Leu Pro 
    1895                 1900                 1905             


Gln Glu  Ile Ile Ala Asn Ala  Lys Ala Leu Pro Tyr  Leu Gln Gln 
    1910                 1915                 1920             


Asp Pro  Val Ser Gly Leu Ser  Gly Arg Ser Gly Tyr  Pro Ser Met 
    1925                 1930                 1935             


Ser Pro  Leu Ser Pro Gln Asp  Ile Phe Gln Leu Ala  Cys Met Asp 
    1940                 1945                 1950             


Pro Ala  Asp Asp Gly Gln Phe  Gln Glu Arg Gln Ser  Leu Val Val 
    1955                 1960                 1965             


Thr Asp  Pro Ser Ser Met Arg  Arg Ser Phe Ser Thr  Ile Arg Asp 
    1970                 1975                 1980             


Lys Arg  Ser Asn Ser Ser Trp  Leu Glu Glu Phe Ser  Met Glu Arg 
    1985                 1990                 1995             


Ser Ser  Glu Asn Thr Tyr Lys  Ser Arg Arg Arg Ser  Tyr His Ser 
    2000                 2005                 2010             


Ser Leu  Arg Leu Ser Ala His  Arg Leu Asn Ser Asp  Ser Gly His 
    2015                 2020                 2025             


Lys Ser  Asp Thr His Arg Ser  Gly Gly Arg Glu Arg  Gly Arg Ser 
    2030                 2035                 2040             


Lys Glu  Arg Lys His Leu Leu  Ser Pro Asp Val Ser  Arg Cys Asn 
    2045                 2050                 2055             


Ser Glu  Glu Arg Gly Thr Gln  Ala Asp Trp Glu Ser  Pro Glu Arg 
    2060                 2065                 2070             


Arg Gln  Ser Arg Ser Pro Ser  Glu Gly Arg Ser Gln  Thr Pro Asn 
    2075                 2080                 2085             


Arg Gln  Gly Thr Gly Ser Leu  Ser Glu Ser Ser Ile  Pro Ser Val 
    2090                 2095                 2100             


Ser Asp  Thr Ser Thr Pro Arg  Arg Ser Arg Arg Gln  Leu Pro Pro 
    2105                 2110                 2115             


Val Pro  Pro Lys Pro Arg Pro  Leu Leu Ser Tyr Ser  Ser Leu Ile 
    2120                 2125                 2130             


Arg His  Ala Gly Ser Ile Ser  Pro Pro Ala Asp Gly  Ser Glu Glu 
    2135                 2140                 2145             


Gly Ser  Pro Leu Thr Ser Gln  Ala Leu Glu Ser Asn  Asn Ala Cys 
    2150                 2155                 2160             


Leu Thr  Glu Ser Ser Asn Ser  Pro His Pro Gln Gln  Ser Gln His 
    2165                 2170                 2175             


Ala Ser  Pro Gln Arg Tyr Ile  Ser Glu Pro Tyr Leu  Ala Leu His 
    2180                 2185                 2190             


Glu Asp  Ser His Ala Ser Asp  Cys Gly Glu Glu Glu  Thr Leu Thr 
    2195                 2200                 2205             


Phe Glu  Ala Ala Val Ala Thr  Ser Leu Gly Arg Ser  Asn Thr Ile 
    2210                 2215                 2220             


Gly Ser  Ala Pro Pro Leu Arg  His Ser Trp Gln Met  Pro Asn Gly 
    2225                 2230                 2235             


His Tyr  Arg Arg Arg Arg Arg  Gly Gly Pro Gly Pro  Gly Met Met 
    2240                 2245                 2250             


Cys Gly  Ala Val Asn Asn Leu  Leu Ser Asp Thr Glu  Glu Asp Asp 
    2255                 2260                 2265             


Lys Cys  
    2270 


<210>  215
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  215

Met Ser Gln Thr Lys Met Leu Lys Val Arg Val Thr Leu Phe Cys Ile 
1               5                   10                  15      


Leu Ala Gly Ile Val Leu Ala Met Thr Ala Val Val Thr Asp His Trp 
            20                  25                  30          


Ala Val Leu Ser Pro His Met Glu His His Asn Thr Thr Cys Glu Ala 
        35                  40                  45              


Ala His Phe Gly Leu Trp Arg Ile Cys Thr Lys Arg Ile Pro Met Asp 
    50                  55                  60                  


Asp Ser Lys Thr Cys Gly Pro Ile Thr Leu Pro Gly Glu Lys Asn Cys 
65                  70                  75                  80  


Ser Tyr Phe Arg His Phe Asn Pro Gly Glu Ser Ser Glu Ile Phe Glu 
                85                  90                  95      


Phe Thr Thr Gln Lys Glu Tyr Ser Ile Ser Ala Ala Ala Ile Ala Ile 
            100                 105                 110         


Phe Ser Leu Gly Phe Ile Ile Leu Gly Ser Leu Cys Val Leu Leu Ser 
        115                 120                 125             


Leu Gly Lys Lys Arg Asp Tyr Leu Leu Arg Pro Ala Ser Met Phe Tyr 
    130                 135                 140                 


Ala Phe Ala Gly Leu Cys Ile Leu Val Ser Val Glu Val Met Arg Gln 
145                 150                 155                 160 


Ser Val Lys Arg Met Ile Asp Ser Glu Asp Thr Val Trp Ile Glu Tyr 
                165                 170                 175     


Tyr Tyr Ser Trp Ser Phe Ala Cys Ala Cys Ala Ala Phe Ile Leu Leu 
            180                 185                 190         


Phe Leu Gly Gly Leu Ala Leu Leu Leu Phe Ser Leu Pro Arg Met Pro 
        195                 200                 205             


Arg Asn Pro Trp Glu Ser Cys Met Asp Ala Glu Pro Glu His 
    210                 215                 220         


<210>  216
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  216

Met Asp Val Val Asp Ser Leu Leu Val Asn Gly Ser Asn Ile Thr Pro 
1               5                   10                  15      


Pro Cys Glu Leu Gly Leu Glu Asn Glu Thr Leu Phe Cys Leu Asp Gln 
            20                  25                  30          


Pro Arg Pro Ser Lys Glu Trp Gln Pro Ala Val Gln Ile Leu Leu Tyr 
        35                  40                  45              


Ser Leu Ile Phe Leu Leu Ser Val Leu Gly Asn Thr Leu Val Ile Thr 
    50                  55                  60                  


Val Leu Ile Arg Asn Lys Arg Met Arg Thr Val Thr Asn Ile Phe Leu 
65                  70                  75                  80  


Leu Ser Leu Ala Val Ser Asp Leu Met Leu Cys Leu Phe Cys Met Pro 
                85                  90                  95      


Phe Asn Leu Ile Pro Asn Leu Leu Lys Asp Phe Ile Phe Gly Ser Ala 
            100                 105                 110         


Val Cys Lys Thr Thr Thr Tyr Phe Met Gly Thr Ser Val Ser Val Ser 
        115                 120                 125             


Thr Phe Asn Leu Val Ala Ile Ser Leu Glu Arg Tyr Gly Ala Ile Cys 
    130                 135                 140                 


Lys Pro Leu Gln Ser Arg Val Trp Gln Thr Lys Ser His Ala Leu Lys 
145                 150                 155                 160 


Val Ile Ala Ala Thr Trp Cys Leu Ser Phe Thr Ile Met Thr Pro Tyr 
                165                 170                 175     


Pro Ile Tyr Ser Asn Leu Val Pro Phe Thr Lys Asn Asn Asn Gln Thr 
            180                 185                 190         


Ala Asn Met Cys Arg Phe Leu Leu Pro Asn Asp Val Met Gln Gln Ser 
        195                 200                 205             


Trp His Thr Phe Leu Leu Leu Ile Leu Phe Leu Ile Pro Gly Ile Val 
    210                 215                 220                 


Met Met Val Ala Tyr Gly Leu Ile Ser Leu Glu Leu Tyr Gln Gly Ile 
225                 230                 235                 240 


Lys Phe Glu Ala Ser Gln Lys Lys Ser Ala Lys Glu Arg Lys Pro Ser 
                245                 250                 255     


Thr Thr Ser Ser Gly Lys Tyr Glu Asp Ser Asp Gly Cys Tyr Leu Gln 
            260                 265                 270         


Lys Thr Arg Pro Pro Arg Lys Leu Glu Leu Arg Gln Leu Ser Thr Gly 
        275                 280                 285             


Ser Ser Ser Arg Ala Asn Arg Ile Arg Ser Asn Ser Ser Ala Ala Asn 
    290                 295                 300                 


Leu Met Ala Lys Lys Arg Val Ile Arg Met Leu Ile Val Ile Val Val 
305                 310                 315                 320 


Leu Phe Phe Leu Cys Trp Met Pro Ile Phe Ser Ala Asn Ala Trp Arg 
                325                 330                 335     


Ala Tyr Asp Thr Ala Ser Ala Glu Arg Arg Leu Ser Gly Thr Pro Ile 
            340                 345                 350         


Ser Phe Ile Leu Leu Leu Ser Tyr Thr Ser Ser Cys Val Asn Pro Ile 
        355                 360                 365             


Ile Tyr Cys Phe Met Asn Lys Arg Phe Arg Leu Gly Phe Met Ala Thr 
    370                 375                 380                 


Phe Pro Cys Cys Pro Asn Pro Gly Pro Pro Gly Ala Arg Gly Glu Val 
385                 390                 395                 400 


Gly Glu Glu Glu Glu Gly Gly Thr Thr Gly Ala Ser Leu Ser Arg Phe 
                405                 410                 415     


Ser Tyr Ser His Met Ser Ala Ser Val Pro Pro Gln 
            420                 425             


<210>  217
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  217

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 


Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 


Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
                165                 170     


<210>  218
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  218

Met Asp Tyr Tyr Arg Lys Tyr Ala Ala Ile Phe Leu Val Thr Leu Ser 
1               5                   10                  15      


Val Phe Leu His Val Leu His Ser Ala Pro Asp Val Gln Asp Cys Pro 
            20                  25                  30          


Glu Cys Thr Leu Gln Glu Asn Pro Phe Phe Ser Gln Pro Gly Ala Pro 
        35                  40                  45              


Ile Leu Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro 
    50                  55                  60                  


Leu Arg Ser Lys Lys Thr Met Leu Val Gln Lys Asn Val Thr Ser Glu 
65                  70                  75                  80  


Ser Thr Cys Cys Val Ala Lys Ser Tyr Asn Arg Val Thr Val Met Gly 
                85                  90                  95      


Gly Phe Lys Val Glu Asn His Thr Ala Cys His Cys Ser Thr Cys Tyr 
            100                 105                 110         


Tyr His Lys Ser 
        115     


<210>  219
<211>  460
<212>  PRT
<213>  Homo sapiens

<400>  219

Met Asn Thr Ser Ala Pro Pro Ala Val Ser Pro Asn Ile Thr Val Leu 
1               5                   10                  15      


Ala Pro Gly Lys Gly Pro Trp Gln Val Ala Phe Ile Gly Ile Thr Thr 
            20                  25                  30          


Gly Leu Leu Ser Leu Ala Thr Val Thr Gly Asn Leu Leu Val Leu Ile 
        35                  40                  45              


Ser Phe Lys Val Asn Thr Glu Leu Lys Thr Val Asn Asn Tyr Phe Leu 
    50                  55                  60                  


Leu Ser Leu Ala Cys Ala Asp Leu Ile Ile Gly Thr Phe Ser Met Asn 
65                  70                  75                  80  


Leu Tyr Thr Thr Tyr Leu Leu Met Gly His Trp Ala Leu Gly Thr Leu 
                85                  90                  95      


Ala Cys Asp Leu Trp Leu Ala Leu Asp Tyr Val Ala Ser Asn Ala Ser 
            100                 105                 110         


Val Met Asn Leu Leu Leu Ile Ser Phe Asp Arg Tyr Phe Ser Val Thr 
        115                 120                 125             


Arg Pro Leu Ser Tyr Arg Ala Lys Arg Thr Pro Arg Arg Ala Ala Leu 
    130                 135                 140                 


Met Ile Gly Leu Ala Trp Leu Val Ser Phe Val Leu Trp Ala Pro Ala 
145                 150                 155                 160 


Ile Leu Phe Trp Gln Tyr Leu Val Gly Glu Arg Thr Val Leu Ala Gly 
                165                 170                 175     


Gln Cys Tyr Ile Gln Phe Leu Ser Gln Pro Ile Ile Thr Phe Gly Thr 
            180                 185                 190         


Ala Met Ala Ala Phe Tyr Leu Pro Val Thr Val Met Cys Thr Leu Tyr 
        195                 200                 205             


Trp Arg Ile Tyr Arg Glu Thr Glu Asn Arg Ala Arg Glu Leu Ala Ala 
    210                 215                 220                 


Leu Gln Gly Ser Glu Thr Pro Gly Lys Gly Gly Gly Ser Ser Ser Ser 
225                 230                 235                 240 


Ser Glu Arg Ser Gln Pro Gly Ala Glu Gly Ser Pro Glu Thr Pro Pro 
                245                 250                 255     


Gly Arg Cys Cys Arg Cys Cys Arg Ala Pro Arg Leu Leu Gln Ala Tyr 
            260                 265                 270         


Ser Trp Lys Glu Glu Glu Glu Glu Asp Glu Gly Ser Met Glu Ser Leu 
        275                 280                 285             


Thr Ser Ser Glu Gly Glu Glu Pro Gly Ser Glu Val Val Ile Lys Met 
    290                 295                 300                 


Pro Met Val Asp Pro Glu Ala Gln Ala Pro Thr Lys Gln Pro Pro Arg 
305                 310                 315                 320 


Ser Ser Pro Asn Thr Val Lys Arg Pro Thr Lys Lys Gly Arg Asp Arg 
                325                 330                 335     


Ala Gly Lys Gly Gln Lys Pro Arg Gly Lys Glu Gln Leu Ala Lys Arg 
            340                 345                 350         


Lys Thr Phe Ser Leu Val Lys Glu Lys Lys Ala Ala Arg Thr Leu Ser 
        355                 360                 365             


Ala Ile Leu Leu Ala Phe Ile Leu Thr Trp Thr Pro Tyr Asn Ile Met 
    370                 375                 380                 


Val Leu Val Ser Thr Phe Cys Lys Asp Cys Val Pro Glu Thr Leu Trp 
385                 390                 395                 400 


Glu Leu Gly Tyr Trp Leu Cys Tyr Val Asn Ser Thr Ile Asn Pro Met 
                405                 410                 415     


Cys Tyr Ala Leu Cys Asn Lys Ala Phe Arg Asp Thr Phe Arg Leu Leu 
            420                 425                 430         


Leu Leu Cys Arg Trp Asp Lys Arg Arg Trp Arg Lys Ile Pro Lys Arg 
        435                 440                 445             


Pro Gly Ser Val His Arg Thr Pro Ser Arg Gln Cys 
    450                 455                 460 


<210>  220
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  220

Met Asn Asn Ser Thr Asn Ser Ser Asn Asn Ser Leu Ala Leu Thr Ser 
1               5                   10                  15      


Pro Tyr Lys Thr Phe Glu Val Val Phe Ile Val Leu Val Ala Gly Ser 
            20                  25                  30          


Leu Ser Leu Val Thr Ile Ile Gly Asn Ile Leu Val Met Val Ser Ile 
        35                  40                  45              


Lys Val Asn Arg His Leu Gln Thr Val Asn Asn Tyr Phe Leu Phe Ser 
    50                  55                  60                  


Leu Ala Cys Ala Asp Leu Ile Ile Gly Val Phe Ser Met Asn Leu Tyr 
65                  70                  75                  80  


Thr Leu Tyr Thr Val Ile Gly Tyr Trp Pro Leu Gly Pro Val Val Cys 
                85                  90                  95      


Asp Leu Trp Leu Ala Leu Asp Tyr Val Val Ser Asn Ala Ser Val Met 
            100                 105                 110         


Asn Leu Leu Ile Ile Ser Phe Asp Arg Tyr Phe Cys Val Thr Lys Pro 
        115                 120                 125             


Leu Thr Tyr Pro Val Lys Arg Thr Thr Lys Met Ala Gly Met Met Ile 
    130                 135                 140                 


Ala Ala Ala Trp Val Leu Ser Phe Ile Leu Trp Ala Pro Ala Ile Leu 
145                 150                 155                 160 


Phe Trp Gln Phe Ile Val Gly Val Arg Thr Val Glu Asp Gly Glu Cys 
                165                 170                 175     


Tyr Ile Gln Phe Phe Ser Asn Ala Ala Val Thr Phe Gly Thr Ala Ile 
            180                 185                 190         


Ala Ala Phe Tyr Leu Pro Val Ile Ile Met Thr Val Leu Tyr Trp His 
        195                 200                 205             


Ile Ser Arg Ala Ser Lys Ser Arg Ile Lys Lys Asp Lys Lys Glu Pro 
    210                 215                 220                 


Val Ala Asn Gln Asp Pro Val Ser Pro Ser Leu Val Gln Gly Arg Ile 
225                 230                 235                 240 


Val Lys Pro Asn Asn Asn Asn Met Pro Ser Ser Asp Asp Gly Leu Glu 
                245                 250                 255     


His Asn Lys Ile Gln Asn Gly Lys Ala Pro Arg Asp Pro Val Thr Glu 
            260                 265                 270         


Asn Cys Val Gln Gly Glu Glu Lys Glu Ser Ser Asn Asp Ser Thr Ser 
        275                 280                 285             


Val Ser Ala Val Ala Ser Asn Met Arg Asp Asp Glu Ile Thr Gln Asp 
    290                 295                 300                 


Glu Asn Thr Val Ser Thr Ser Leu Gly His Ser Lys Asp Glu Asn Ser 
305                 310                 315                 320 


Lys Gln Thr Cys Ile Arg Ile Gly Thr Lys Thr Pro Lys Ser Asp Ser 
                325                 330                 335     


Cys Thr Pro Thr Asn Thr Thr Val Glu Val Val Gly Ser Ser Gly Gln 
            340                 345                 350         


Asn Gly Asp Glu Lys Gln Asn Ile Val Ala Arg Lys Ile Val Lys Met 
        355                 360                 365             


Thr Lys Gln Pro Ala Lys Lys Lys Pro Pro Pro Ser Arg Glu Lys Lys 
    370                 375                 380                 


Val Thr Arg Thr Ile Leu Ala Ile Leu Leu Ala Phe Ile Ile Thr Trp 
385                 390                 395                 400 


Ala Pro Tyr Asn Val Met Val Leu Ile Asn Thr Phe Cys Ala Pro Cys 
                405                 410                 415     


Ile Pro Asn Thr Val Trp Thr Ile Gly Tyr Trp Leu Cys Tyr Ile Asn 
            420                 425                 430         


Ser Thr Ile Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys 
        435                 440                 445             


Lys Thr Phe Lys His Leu Leu Met Cys His Tyr Lys Asn Ile Gly Ala 
    450                 455                 460                 


Thr Arg 
465     


<210>  221
<211>  590
<212>  PRT
<213>  Homo sapiens

<400>  221

Met Thr Leu His Asn Asn Ser Thr Thr Ser Pro Leu Phe Pro Asn Ile 
1               5                   10                  15      


Ser Ser Ser Trp Ile His Ser Pro Ser Asp Ala Gly Leu Pro Pro Gly 
            20                  25                  30          


Thr Val Thr His Phe Gly Ser Tyr Asn Val Ser Arg Ala Ala Gly Asn 
        35                  40                  45              


Phe Ser Ser Pro Asp Gly Thr Thr Asp Asp Pro Leu Gly Gly His Thr 
    50                  55                  60                  


Val Trp Gln Val Val Phe Ile Ala Phe Leu Thr Gly Ile Leu Ala Leu 
65                  70                  75                  80  


Val Thr Ile Ile Gly Asn Ile Leu Val Ile Val Ser Phe Lys Val Asn 
                85                  90                  95      


Lys Gln Leu Lys Thr Val Asn Asn Tyr Phe Leu Leu Ser Leu Ala Cys 
            100                 105                 110         


Ala Asp Leu Ile Ile Gly Val Ile Ser Met Asn Leu Phe Thr Thr Tyr 
        115                 120                 125             


Ile Ile Met Asn Arg Trp Ala Leu Gly Asn Leu Ala Cys Asp Leu Trp 
    130                 135                 140                 


Leu Ala Ile Asp Tyr Val Ala Ser Asn Ala Ser Val Met Asn Leu Leu 
145                 150                 155                 160 


Val Ile Ser Phe Asp Arg Tyr Phe Ser Ile Thr Arg Pro Leu Thr Tyr 
                165                 170                 175     


Arg Ala Lys Arg Thr Thr Lys Arg Ala Gly Val Met Ile Gly Leu Ala 
            180                 185                 190         


Trp Val Ile Ser Phe Val Leu Trp Ala Pro Ala Ile Leu Phe Trp Gln 
        195                 200                 205             


Tyr Phe Val Gly Lys Arg Thr Val Pro Pro Gly Glu Cys Phe Ile Gln 
    210                 215                 220                 


Phe Leu Ser Glu Pro Thr Ile Thr Phe Gly Thr Ala Ile Ala Ala Phe 
225                 230                 235                 240 


Tyr Met Pro Val Thr Ile Met Thr Ile Leu Tyr Trp Arg Ile Tyr Lys 
                245                 250                 255     


Glu Thr Glu Lys Arg Thr Lys Glu Leu Ala Gly Leu Gln Ala Ser Gly 
            260                 265                 270         


Thr Glu Ala Glu Thr Glu Asn Phe Val His Pro Thr Gly Ser Ser Arg 
        275                 280                 285             


Ser Cys Ser Ser Tyr Glu Leu Gln Gln Gln Ser Met Lys Arg Ser Asn 
    290                 295                 300                 


Arg Arg Lys Tyr Gly Arg Cys His Phe Trp Phe Thr Thr Lys Ser Trp 
305                 310                 315                 320 


Lys Pro Ser Ser Glu Gln Met Asp Gln Asp His Ser Ser Ser Asp Ser 
                325                 330                 335     


Trp Asn Asn Asn Asp Ala Ala Ala Ser Leu Glu Asn Ser Ala Ser Ser 
            340                 345                 350         


Asp Glu Glu Asp Ile Gly Ser Glu Thr Arg Ala Ile Tyr Ser Ile Val 
        355                 360                 365             


Leu Lys Leu Pro Gly His Ser Thr Ile Leu Asn Ser Thr Lys Leu Pro 
    370                 375                 380                 


Ser Ser Asp Asn Leu Gln Val Pro Glu Glu Glu Leu Gly Met Val Asp 
385                 390                 395                 400 


Leu Glu Arg Lys Ala Asp Lys Leu Gln Ala Gln Lys Ser Val Asp Asp 
                405                 410                 415     


Gly Gly Ser Phe Pro Lys Ser Phe Ser Lys Leu Pro Ile Gln Leu Glu 
            420                 425                 430         


Ser Ala Val Asp Thr Ala Lys Thr Ser Asp Val Asn Ser Ser Val Gly 
        435                 440                 445             


Lys Ser Thr Ala Thr Leu Pro Leu Ser Phe Lys Glu Ala Thr Leu Ala 
    450                 455                 460                 


Lys Arg Phe Ala Leu Lys Thr Arg Ser Gln Ile Thr Lys Arg Lys Arg 
465                 470                 475                 480 


Met Ser Leu Val Lys Glu Lys Lys Ala Ala Gln Thr Leu Ser Ala Ile 
                485                 490                 495     


Leu Leu Ala Phe Ile Ile Thr Trp Thr Pro Tyr Asn Ile Met Val Leu 
            500                 505                 510         


Val Asn Thr Phe Cys Asp Ser Cys Ile Pro Lys Thr Phe Trp Asn Leu 
        515                 520                 525             


Gly Tyr Trp Leu Cys Tyr Ile Asn Ser Thr Val Asn Pro Val Cys Tyr 
    530                 535                 540                 


Ala Leu Cys Asn Lys Thr Phe Arg Thr Thr Phe Lys Met Leu Leu Leu 
545                 550                 555                 560 


Cys Gln Cys Asp Lys Lys Lys Arg Arg Lys Gln Gln Tyr Gln Gln Arg 
                565                 570                 575     


Gln Ser Val Ile Phe His Lys Arg Ala Pro Glu Gln Ala Leu 
            580                 585                 590 


<210>  222
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  222

Met Ala Asn Phe Thr Pro Val Asn Gly Ser Ser Gly Asn Gln Ser Val 
1               5                   10                  15      


Arg Leu Val Thr Ser Ser Ser His Asn Arg Tyr Glu Thr Val Glu Met 
            20                  25                  30          


Val Phe Ile Ala Thr Val Thr Gly Ser Leu Ser Leu Val Thr Val Val 
        35                  40                  45              


Gly Asn Ile Leu Val Met Leu Ser Ile Lys Val Asn Arg Gln Leu Gln 
    50                  55                  60                  


Thr Val Asn Asn Tyr Phe Leu Phe Ser Leu Ala Cys Ala Asp Leu Ile 
65                  70                  75                  80  


Ile Gly Ala Phe Ser Met Asn Leu Tyr Thr Val Tyr Ile Ile Lys Gly 
                85                  90                  95      


Tyr Trp Pro Leu Gly Ala Val Val Cys Asp Leu Trp Leu Ala Leu Asp 
            100                 105                 110         


Tyr Val Val Ser Asn Ala Ser Val Met Asn Leu Leu Ile Ile Ser Phe 
        115                 120                 125             


Asp Arg Tyr Phe Cys Val Thr Lys Pro Leu Thr Tyr Pro Ala Arg Arg 
    130                 135                 140                 


Thr Thr Lys Met Ala Gly Leu Met Ile Ala Ala Ala Trp Val Leu Ser 
145                 150                 155                 160 


Phe Val Leu Trp Ala Pro Ala Ile Leu Phe Trp Gln Phe Val Val Gly 
                165                 170                 175     


Lys Arg Thr Val Pro Asp Asn Gln Cys Phe Ile Gln Phe Leu Ser Asn 
            180                 185                 190         


Pro Ala Val Thr Phe Gly Thr Ala Ile Ala Ala Phe Tyr Leu Pro Val 
        195                 200                 205             


Val Ile Met Thr Val Leu Tyr Ile His Ile Ser Leu Ala Ser Arg Ser 
    210                 215                 220                 


Arg Val His Lys His Arg Pro Glu Gly Pro Lys Glu Lys Lys Ala Lys 
225                 230                 235                 240 


Thr Leu Ala Phe Leu Lys Ser Pro Leu Met Lys Gln Ser Val Lys Lys 
                245                 250                 255     


Pro Pro Pro Gly Glu Ala Ala Arg Glu Glu Leu Arg Asn Gly Lys Leu 
            260                 265                 270         


Glu Glu Ala Pro Pro Pro Ala Leu Pro Pro Pro Pro Arg Pro Val Ala 
        275                 280                 285             


Asp Lys Asp Thr Ser Asn Glu Ser Ser Ser Gly Ser Ala Thr Gln Asn 
    290                 295                 300                 


Thr Lys Glu Arg Pro Ala Thr Glu Leu Ser Thr Thr Glu Ala Thr Thr 
305                 310                 315                 320 


Pro Ala Met Pro Ala Pro Pro Leu Gln Pro Arg Ala Leu Asn Pro Ala 
                325                 330                 335     


Ser Arg Trp Ser Lys Ile Gln Ile Val Thr Lys Gln Thr Gly Asn Glu 
            340                 345                 350         


Cys Val Thr Ala Ile Glu Ile Val Pro Ala Thr Pro Ala Gly Met Arg 
        355                 360                 365             


Pro Ala Ala Asn Val Ala Arg Lys Phe Ala Ser Ile Ala Arg Asn Gln 
    370                 375                 380                 


Val Arg Lys Lys Arg Gln Met Ala Ala Arg Glu Arg Lys Val Thr Arg 
385                 390                 395                 400 


Thr Ile Phe Ala Ile Leu Leu Ala Phe Ile Leu Thr Trp Thr Pro Tyr 
                405                 410                 415     


Asn Val Met Val Leu Val Asn Thr Phe Cys Gln Ser Cys Ile Pro Asp 
            420                 425                 430         


Thr Val Trp Ser Ile Gly Tyr Trp Leu Cys Tyr Val Asn Ser Thr Ile 
        435                 440                 445             


Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys Lys Thr Phe 
    450                 455                 460                 


Arg His Leu Leu Leu Cys Gln Tyr Arg Asn Ile Gly Thr Ala Arg 
465                 470                 475                 


<210>  223
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  223

Met Gly Pro Ser Cys Pro Val Phe Leu Ser Phe Thr Lys Leu Ser Leu 
1               5                   10                  15      


Trp Trp Leu Leu Leu Thr Pro Ala Gly Gly Glu Glu Ala Lys Arg Pro 
            20                  25                  30          


Pro Pro Arg Ala Pro Gly Asp Pro Leu Ser Ser Pro Ser Pro Thr Ala 
        35                  40                  45              


Leu Pro Gln Gly Gly Ser His Thr Glu Thr Glu Asp Arg Leu Phe Lys 
    50                  55                  60                  


His Leu Phe Arg Gly Tyr Asn Arg Trp Ala Arg Pro Val Pro Asn Thr 
65                  70                  75                  80  


Ser Asp Val Val Ile Val Arg Phe Gly Leu Ser Ile Ala Gln Leu Ile 
                85                  90                  95      


Asp Val Asp Glu Lys Asn Gln Met Met Thr Thr Asn Val Trp Leu Lys 
            100                 105                 110         


Gln Glu Trp Ser Asp Tyr Lys Leu Arg Trp Asn Pro Thr Asp Phe Gly 
        115                 120                 125             


Asn Ile Thr Ser Leu Arg Val Pro Ser Glu Met Ile Trp Ile Pro Asp 
    130                 135                 140                 


Ile Val Leu Tyr Asn Asn Ala Asp Gly Glu Phe Ala Val Thr His Met 
145                 150                 155                 160 


Thr Lys Ala His Leu Phe Ser Thr Gly Thr Val His Trp Val Pro Pro 
                165                 170                 175     


Ala Ile Tyr Lys Ser Ser Cys Ser Ile Asp Val Thr Phe Phe Pro Phe 
            180                 185                 190         


Asp Gln Gln Asn Cys Lys Met Lys Phe Gly Ser Trp Thr Tyr Asp Lys 
        195                 200                 205             


Ala Lys Ile Asp Leu Glu Gln Met Glu Gln Thr Val Asp Leu Lys Asp 
    210                 215                 220                 


Tyr Trp Glu Ser Gly Glu Trp Ala Ile Val Asn Ala Thr Gly Thr Tyr 
225                 230                 235                 240 


Asn Ser Lys Lys Tyr Asp Cys Cys Ala Glu Ile Tyr Pro Asp Val Thr 
                245                 250                 255     


Tyr Ala Phe Val Ile Arg Arg Leu Pro Leu Phe Tyr Thr Ile Asn Leu 
            260                 265                 270         


Ile Ile Pro Cys Leu Leu Ile Ser Cys Leu Thr Val Leu Val Phe Tyr 
        275                 280                 285             


Leu Pro Ser Asp Cys Gly Glu Lys Ile Thr Leu Cys Ile Ser Val Leu 
    290                 295                 300                 


Leu Ser Leu Thr Val Phe Leu Leu Leu Ile Thr Glu Ile Ile Pro Ser 
305                 310                 315                 320 


Thr Ser Leu Val Ile Pro Leu Ile Gly Glu Tyr Leu Leu Phe Thr Met 
                325                 330                 335     


Ile Phe Val Thr Leu Ser Ile Val Ile Thr Val Phe Val Leu Asn Val 
            340                 345                 350         


His His Arg Ser Pro Ser Thr His Thr Met Pro His Trp Val Arg Gly 
        355                 360                 365             


Ala Leu Leu Gly Cys Val Pro Arg Trp Leu Leu Met Asn Arg Pro Pro 
    370                 375                 380                 


Pro Pro Val Glu Leu Cys His Pro Leu Arg Leu Lys Leu Ser Pro Ser 
385                 390                 395                 400 


Tyr His Trp Leu Glu Ser Asn Val Asp Ala Glu Glu Arg Glu Val Val 
                405                 410                 415     


Val Glu Glu Glu Asp Arg Trp Ala Cys Ala Gly His Val Ala Pro Ser 
            420                 425                 430         


Val Gly Thr Leu Cys Ser His Gly His Leu His Ser Gly Ala Ser Gly 
        435                 440                 445             


Pro Lys Ala Glu Ala Leu Leu Gln Glu Gly Glu Leu Leu Leu Ser Pro 
    450                 455                 460                 


His Met Gln Lys Ala Leu Glu Gly Val His Tyr Ile Ala Asp His Leu 
465                 470                 475                 480 


Arg Ser Glu Asp Ala Asp Ser Ser Val Lys Glu Asp Trp Lys Tyr Val 
                485                 490                 495     


Ala Met Val Ile Asp Arg Ile Phe Leu Trp Leu Phe Ile Ile Val Cys 
            500                 505                 510         


Phe Leu Gly Thr Ile Gly Leu Phe Leu Pro Pro Phe Leu Ala Gly Met 
        515                 520                 525             


Ile 
    


<210>  224
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  224

Met Gly Ser Gly Pro Leu Ser Leu Pro Leu Ala Leu Ser Pro Pro Arg 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Ser Leu Leu Pro Val Ala Arg Ala Ser 
            20                  25                  30          


Glu Ala Glu His Arg Leu Phe Glu Arg Leu Phe Glu Asp Tyr Asn Glu 
        35                  40                  45              


Ile Ile Arg Pro Val Ala Asn Val Ser Asp Pro Val Ile Ile His Phe 
    50                  55                  60                  


Glu Val Ser Met Ser Gln Leu Val Lys Val Asp Glu Val Asn Gln Ile 
65                  70                  75                  80  


Met Glu Thr Asn Leu Trp Leu Lys Gln Ile Trp Asn Asp Tyr Lys Leu 
                85                  90                  95      


Lys Trp Asn Pro Ser Asp Tyr Gly Gly Ala Glu Phe Met Arg Val Pro 
            100                 105                 110         


Ala Gln Lys Ile Trp Lys Pro Asp Ile Val Leu Tyr Asn Asn Ala Val 
        115                 120                 125             


Gly Asp Phe Gln Val Asp Asp Lys Thr Lys Ala Leu Leu Lys Tyr Thr 
    130                 135                 140                 


Gly Glu Val Thr Trp Ile Pro Pro Ala Ile Phe Lys Ser Ser Cys Lys 
145                 150                 155                 160 


Ile Asp Val Thr Tyr Phe Pro Phe Asp Tyr Gln Asn Cys Thr Met Lys 
                165                 170                 175     


Phe Gly Ser Trp Ser Tyr Asp Lys Ala Lys Ile Asp Leu Val Leu Ile 
            180                 185                 190         


Gly Ser Ser Met Asn Leu Lys Asp Tyr Trp Glu Ser Gly Glu Trp Ala 
        195                 200                 205             


Ile Ile Lys Ala Pro Gly Tyr Lys His Asp Ile Lys Tyr Asn Cys Cys 
    210                 215                 220                 


Glu Glu Ile Tyr Pro Asp Ile Thr Tyr Ser Leu Tyr Ile Arg Arg Leu 
225                 230                 235                 240 


Pro Leu Phe Tyr Thr Ile Asn Leu Ile Ile Pro Cys Leu Leu Ile Ser 
                245                 250                 255     


Phe Leu Thr Val Leu Val Phe Tyr Leu Pro Ser Asp Cys Gly Glu Lys 
            260                 265                 270         


Val Thr Leu Cys Ile Ser Val Leu Leu Ser Leu Thr Val Phe Leu Leu 
        275                 280                 285             


Val Ile Thr Glu Thr Ile Pro Ser Thr Ser Leu Val Ile Pro Leu Ile 
    290                 295                 300                 


Gly Glu Tyr Leu Leu Phe Thr Met Ile Phe Val Thr Leu Ser Ile Val 
305                 310                 315                 320 


Ile Thr Val Phe Val Leu Asn Val His Tyr Arg Thr Pro Thr Thr His 
                325                 330                 335     


Thr Met Pro Ser Trp Val Lys Thr Val Phe Leu Asn Leu Leu Pro Arg 
            340                 345                 350         


Val Met Phe Met Thr Arg Pro Thr Ser Asn Glu Gly Asn Ala Gln Lys 
        355                 360                 365             


Pro Arg Pro Leu Tyr Gly Ala Glu Leu Ser Asn Leu Asn Cys Phe Ser 
    370                 375                 380                 


Arg Ala Glu Ser Lys Gly Cys Lys Glu Gly Tyr Pro Cys Gln Asp Gly 
385                 390                 395                 400 


Met Cys Gly Tyr Cys His His Arg Arg Ile Lys Ile Ser Asn Phe Ser 
                405                 410                 415     


Ala Asn Leu Thr Arg Ser Ser Ser Ser Glu Ser Val Asp Ala Val Leu 
            420                 425                 430         


Ser Leu Ser Ala Leu Ser Pro Glu Ile Lys Glu Ala Ile Gln Ser Val 
        435                 440                 445             


Lys Tyr Ile Ala Glu Asn Met Lys Ala Gln Asn Glu Ala Lys Glu Ile 
    450                 455                 460                 


Gln Asp Asp Trp Lys Tyr Val Ala Met Val Ile Asp Arg Ile Phe Leu 
465                 470                 475                 480 


Trp Val Phe Thr Leu Val Cys Ile Leu Gly Thr Ala Gly Leu Phe Leu 
                485                 490                 495     


Gln Pro Leu Met Ala Arg Glu Asp Ala 
            500                 505 


<210>  225
<211>  627
<212>  PRT
<213>  Homo sapiens

<400>  225

Met Glu Leu Gly Gly Pro Gly Ala Pro Arg Leu Leu Pro Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Gly Thr Gly Leu Leu Arg Ala Ser Ser His Val Glu Thr 
            20                  25                  30          


Arg Ala His Ala Glu Glu Arg Leu Leu Lys Lys Leu Phe Ser Gly Tyr 
        35                  40                  45              


Asn Lys Trp Ser Arg Pro Val Ala Asn Ile Ser Asp Val Val Leu Val 
    50                  55                  60                  


Arg Phe Gly Leu Ser Ile Ala Gln Leu Ile Asp Val Asp Glu Lys Asn 
65                  70                  75                  80  


Gln Met Met Thr Thr Asn Val Trp Val Lys Gln Glu Trp His Asp Tyr 
                85                  90                  95      


Lys Leu Arg Trp Asp Pro Ala Asp Tyr Glu Asn Val Thr Ser Ile Arg 
            100                 105                 110         


Ile Pro Ser Glu Leu Ile Trp Arg Pro Asp Ile Val Leu Tyr Asn Asn 
        115                 120                 125             


Ala Asp Gly Asp Phe Ala Val Thr His Leu Thr Lys Ala His Leu Phe 
    130                 135                 140                 


His Asp Gly Arg Val Gln Trp Thr Pro Pro Ala Ile Tyr Lys Ser Ser 
145                 150                 155                 160 


Cys Ser Ile Asp Val Thr Phe Phe Pro Phe Asp Gln Gln Asn Cys Thr 
                165                 170                 175     


Met Lys Phe Gly Ser Trp Thr Tyr Asp Lys Ala Lys Ile Asp Leu Val 
            180                 185                 190         


Asn Met His Ser Arg Val Asp Gln Leu Asp Phe Trp Glu Ser Gly Glu 
        195                 200                 205             


Trp Val Ile Val Asp Ala Val Gly Thr Tyr Asn Thr Arg Lys Tyr Glu 
    210                 215                 220                 


Cys Cys Ala Glu Ile Tyr Pro Asp Ile Thr Tyr Ala Phe Val Ile Arg 
225                 230                 235                 240 


Arg Leu Pro Leu Phe Tyr Thr Ile Asn Leu Ile Ile Pro Cys Leu Leu 
                245                 250                 255     


Ile Ser Cys Leu Thr Val Leu Val Phe Tyr Leu Pro Ser Glu Cys Gly 
            260                 265                 270         


Glu Lys Ile Thr Leu Cys Ile Ser Val Leu Leu Ser Leu Thr Val Phe 
        275                 280                 285             


Leu Leu Leu Ile Thr Glu Ile Ile Pro Ser Thr Ser Leu Val Ile Pro 
    290                 295                 300                 


Leu Ile Gly Glu Tyr Leu Leu Phe Thr Met Ile Phe Val Thr Leu Ser 
305                 310                 315                 320 


Ile Val Ile Thr Val Phe Val Leu Asn Val His His Arg Ser Pro Arg 
                325                 330                 335     


Thr His Thr Met Pro Thr Trp Val Arg Arg Val Phe Leu Asp Ile Val 
            340                 345                 350         


Pro Arg Leu Leu Leu Met Lys Arg Pro Ser Val Val Lys Asp Asn Cys 
        355                 360                 365             


Arg Arg Leu Ile Glu Ser Met His Lys Met Ala Ser Ala Pro Arg Phe 
    370                 375                 380                 


Trp Pro Glu Pro Glu Gly Glu Pro Pro Ala Thr Ser Gly Thr Gln Ser 
385                 390                 395                 400 


Leu His Pro Pro Ser Pro Ser Phe Cys Val Pro Leu Asp Val Pro Ala 
                405                 410                 415     


Glu Pro Gly Pro Ser Cys Lys Ser Pro Ser Asp Gln Leu Pro Pro Gln 
            420                 425                 430         


Gln Pro Leu Glu Ala Glu Lys Ala Ser Pro His Pro Ser Pro Gly Pro 
        435                 440                 445             


Cys Arg Pro Pro His Gly Thr Gln Ala Pro Gly Leu Ala Lys Ala Arg 
    450                 455                 460                 


Ser Leu Ser Val Gln His Met Ser Ser Pro Gly Glu Ala Val Glu Gly 
465                 470                 475                 480 


Gly Val Arg Cys Arg Ser Arg Ser Ile Gln Tyr Cys Val Pro Arg Asp 
                485                 490                 495     


Asp Ala Ala Pro Glu Ala Asp Gly Gln Ala Ala Gly Ala Leu Ala Ser 
            500                 505                 510         


Arg Asn Thr His Ser Ala Glu Leu Pro Pro Pro Asp Gln Pro Ser Pro 
        515                 520                 525             


Cys Lys Cys Thr Cys Lys Lys Glu Pro Ser Ser Val Ser Pro Ser Ala 
    530                 535                 540                 


Thr Val Lys Thr Arg Ser Thr Lys Ala Pro Pro Pro His Leu Pro Leu 
545                 550                 555                 560 


Ser Pro Ala Leu Thr Arg Ala Val Glu Gly Val Gln Tyr Ile Ala Asp 
                565                 570                 575     


His Leu Lys Ala Glu Asp Thr Asp Phe Ser Val Lys Glu Asp Trp Lys 
            580                 585                 590         


Tyr Val Ala Met Val Ile Asp Arg Ile Phe Leu Trp Met Phe Ile Ile 
        595                 600                 605             


Val Cys Leu Leu Gly Thr Val Gly Leu Phe Leu Pro Pro Trp Leu Ala 
    610                 615                 620                 


Gly Met Ile 
625         


<210>  226
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  226

Met Ala Ala Arg Gly Ser Gly Pro Arg Ala Leu Arg Leu Leu Leu Leu 
1               5                   10                  15      


Val Gln Leu Val Ala Gly Arg Cys Gly Leu Ala Gly Ala Ala Gly Gly 
            20                  25                  30          


Ala Gln Arg Gly Leu Ser Glu Pro Ser Ser Ile Ala Lys His Glu Asp 
        35                  40                  45              


Ser Leu Leu Lys Asp Leu Phe Gln Asp Tyr Glu Arg Trp Val Arg Pro 
    50                  55                  60                  


Val Glu His Leu Asn Asp Lys Ile Lys Ile Lys Phe Gly Leu Ala Ile 
65                  70                  75                  80  


Ser Gln Leu Val Asp Val Asp Glu Lys Asn Gln Leu Met Thr Thr Asn 
                85                  90                  95      


Val Trp Leu Lys Gln Glu Trp Ile Asp Val Lys Leu Arg Trp Asn Pro 
            100                 105                 110         


Asp Asp Tyr Gly Gly Ile Lys Val Ile Arg Val Pro Ser Asp Ser Val 
        115                 120                 125             


Trp Thr Pro Asp Ile Val Leu Phe Asp Asn Ala Asp Gly Arg Phe Glu 
    130                 135                 140                 


Gly Thr Ser Thr Lys Thr Val Ile Arg Tyr Asn Gly Thr Val Thr Trp 
145                 150                 155                 160 


Thr Pro Pro Ala Asn Tyr Lys Ser Ser Cys Thr Ile Asp Val Thr Phe 
                165                 170                 175     


Phe Pro Phe Asp Leu Gln Asn Cys Ser Met Lys Phe Gly Ser Trp Thr 
            180                 185                 190         


Tyr Asp Gly Ser Gln Val Asp Ile Ile Leu Glu Asp Gln Asp Val Asp 
        195                 200                 205             


Lys Arg Asp Phe Phe Asp Asn Gly Glu Trp Glu Ile Val Ser Ala Thr 
    210                 215                 220                 


Gly Ser Lys Gly Asn Arg Thr Asp Ser Cys Cys Trp Tyr Pro Tyr Val 
225                 230                 235                 240 


Thr Tyr Ser Phe Val Ile Lys Arg Leu Pro Leu Phe Tyr Thr Leu Phe 
                245                 250                 255     


Leu Ile Ile Pro Cys Ile Gly Leu Ser Phe Leu Thr Val Leu Val Phe 
            260                 265                 270         


Tyr Leu Pro Ser Asn Glu Gly Glu Lys Ile Cys Leu Cys Thr Ser Val 
        275                 280                 285             


Leu Val Ser Leu Thr Val Phe Leu Leu Val Ile Glu Glu Ile Ile Pro 
    290                 295                 300                 


Ser Ser Ser Lys Val Ile Pro Leu Ile Gly Glu Tyr Leu Val Phe Thr 
305                 310                 315                 320 


Met Ile Phe Val Thr Leu Ser Ile Met Val Thr Val Phe Ala Ile Asn 
                325                 330                 335     


Ile His His Arg Ser Ser Ser Thr His Asn Ala Met Ala Pro Leu Val 
            340                 345                 350         


Arg Lys Ile Phe Leu His Thr Leu Pro Lys Leu Leu Cys Met Arg Ser 
        355                 360                 365             


His Val Asp Arg Tyr Phe Thr Gln Lys Glu Glu Thr Glu Ser Gly Ser 
    370                 375                 380                 


Gly Pro Lys Ser Ser Arg Asn Thr Leu Glu Ala Ala Leu Asp Ser Ile 
385                 390                 395                 400 


Arg Tyr Ile Thr Arg His Ile Met Lys Glu Asn Asp Val Arg Glu Val 
                405                 410                 415     


Val Glu Asp Trp Lys Phe Ile Ala Gln Val Leu Asp Arg Met Phe Leu 
            420                 425                 430         


Trp Thr Phe Leu Phe Val Ser Ile Val Gly Ser Leu Gly Leu Phe Val 
        435                 440                 445             


Pro Val Ile Tyr Lys Trp Ala Asn Ile Leu Ile Pro Val His Ile Gly 
    450                 455                 460                 


Asn Ala Asn Lys 
465             


<210>  227
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  227

Met Thr Pro Gly Ala Leu Leu Met Leu Leu Gly Ala Leu Gly Ala Pro 
1               5                   10                  15      


Leu Ala Pro Gly Val Arg Gly Ser Glu Ala Glu Gly Arg Leu Arg Glu 
            20                  25                  30          


Lys Leu Phe Ser Gly Tyr Asp Ser Ser Val Arg Pro Ala Arg Glu Val 
        35                  40                  45              


Gly Asp Arg Val Arg Val Ser Val Gly Leu Ile Leu Ala Gln Leu Ile 
    50                  55                  60                  


Ser Leu Asn Glu Lys Asp Glu Glu Met Ser Thr Lys Val Tyr Leu Asp 
65                  70                  75                  80  


Leu Glu Trp Thr Asp Tyr Arg Leu Ser Trp Asp Pro Ala Glu His Asp 
                85                  90                  95      


Gly Ile Asp Ser Leu Arg Ile Thr Ala Glu Ser Val Trp Leu Pro Asp 
            100                 105                 110         


Val Val Leu Leu Asn Asn Asn Asp Gly Asn Phe Asp Val Ala Leu Asp 
        115                 120                 125             


Ile Ser Val Val Val Ser Ser Asp Gly Ser Val Arg Trp Gln Pro Pro 
    130                 135                 140                 


Gly Ile Tyr Arg Ser Ser Cys Ser Ile Gln Val Thr Tyr Phe Pro Phe 
145                 150                 155                 160 


Asp Trp Gln Asn Cys Thr Met Val Phe Ser Ser Tyr Ser Tyr Asp Ser 
                165                 170                 175     


Ser Glu Val Ser Leu Gln Thr Gly Leu Gly Pro Asp Gly Gln Gly His 
            180                 185                 190         


Gln Glu Ile His Ile His Glu Gly Thr Phe Ile Glu Asn Gly Gln Trp 
        195                 200                 205             


Glu Ile Ile His Lys Pro Ser Arg Leu Ile Gln Pro Pro Gly Asp Pro 
    210                 215                 220                 


Arg Gly Gly Arg Glu Gly Gln Arg Gln Glu Val Ile Phe Tyr Leu Ile 
225                 230                 235                 240 


Ile Arg Arg Lys Pro Leu Phe Tyr Leu Val Asn Val Ile Ala Pro Cys 
                245                 250                 255     


Ile Leu Ile Thr Leu Leu Ala Ile Phe Val Phe Tyr Leu Pro Pro Asp 
            260                 265                 270         


Ala Gly Glu Lys Met Gly Leu Ser Ile Phe Ala Leu Leu Thr Leu Thr 
        275                 280                 285             


Val Phe Leu Leu Leu Leu Ala Asp Lys Val Pro Glu Thr Ser Leu Ser 
    290                 295                 300                 


Val Pro Ile Ile Ile Lys Tyr Leu Met Phe Thr Met Val Leu Val Thr 
305                 310                 315                 320 


Phe Ser Val Ile Leu Ser Val Val Val Leu Asn Leu His His Arg Ser 
                325                 330                 335     


Pro His Thr His Gln Met Pro Leu Trp Val Arg Gln Ile Phe Ile His 
            340                 345                 350         


Lys Leu Pro Leu Tyr Leu Arg Leu Lys Arg Pro Lys Pro Glu Arg Asp 
        355                 360                 365             


Leu Met Pro Glu Pro Pro His Cys Ser Ser Pro Gly Ser Gly Trp Gly 
    370                 375                 380                 


Arg Gly Thr Asp Glu Tyr Phe Ile Arg Lys Pro Pro Ser Asp Phe Leu 
385                 390                 395                 400 


Phe Pro Lys Pro Asn Arg Phe Gln Pro Glu Leu Ser Ala Pro Asp Leu 
                405                 410                 415     


Arg Arg Phe Ile Asp Gly Pro Asn Arg Ala Val Ala Leu Leu Pro Glu 
            420                 425                 430         


Leu Arg Glu Val Val Ser Ser Ile Ser Tyr Ile Ala Arg Gln Leu Gln 
        435                 440                 445             


Glu Gln Glu Asp His Asp Ala Leu Lys Glu Asp Trp Gln Phe Val Ala 
    450                 455                 460                 


Met Val Val Asp Arg Leu Phe Leu Trp Thr Phe Ile Ile Phe Thr Ser 
465                 470                 475                 480 


Val Gly Thr Leu Val Ile Phe Leu Asp Ala Thr Tyr His Leu Pro Pro 
                485                 490                 495     


Pro Asp Pro Phe Pro 
            500     


<210>  228
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  228

Met Ala Arg Arg Cys Gly Pro Val Ala Leu Leu Leu Gly Phe Gly Leu 
1               5                   10                  15      


Leu Arg Leu Cys Ser Gly Val Trp Gly Thr Asp Thr Glu Glu Arg Leu 
            20                  25                  30          


Val Glu His Leu Leu Asp Pro Ser Arg Tyr Asn Lys Leu Ile Arg Pro 
        35                  40                  45              


Ala Thr Asn Gly Ser Glu Leu Val Thr Val Gln Leu Met Val Ser Leu 
    50                  55                  60                  


Ala Gln Leu Ile Ser Val His Glu Arg Glu Gln Ile Met Thr Thr Asn 
65                  70                  75                  80  


Val Trp Leu Thr Gln Glu Trp Glu Asp Tyr Arg Leu Thr Trp Lys Pro 
                85                  90                  95      


Glu Glu Phe Asp Asn Met Lys Lys Val Arg Leu Pro Ser Lys His Ile 
            100                 105                 110         


Trp Leu Pro Asp Val Val Leu Tyr Asn Asn Ala Asp Gly Met Tyr Glu 
        115                 120                 125             


Val Ser Phe Tyr Ser Asn Ala Val Val Ser Tyr Asp Gly Ser Ile Phe 
    130                 135                 140                 


Trp Leu Pro Pro Ala Ile Tyr Lys Ser Ala Cys Lys Ile Glu Val Lys 
145                 150                 155                 160 


His Phe Pro Phe Asp Gln Gln Asn Cys Thr Met Lys Phe Arg Ser Trp 
                165                 170                 175     


Thr Tyr Asp Arg Thr Glu Ile Asp Leu Val Leu Lys Ser Glu Val Ala 
            180                 185                 190         


Ser Leu Asp Asp Phe Thr Pro Ser Gly Glu Trp Asp Ile Val Ala Leu 
        195                 200                 205             


Pro Gly Arg Arg Asn Glu Asn Pro Asp Asp Ser Thr Tyr Val Asp Ile 
    210                 215                 220                 


Thr Tyr Asp Phe Ile Ile Arg Arg Lys Pro Leu Phe Tyr Thr Ile Asn 
225                 230                 235                 240 


Leu Ile Ile Pro Cys Val Leu Ile Thr Ser Leu Ala Ile Leu Val Phe 
                245                 250                 255     


Tyr Leu Pro Ser Asp Cys Gly Glu Lys Met Thr Leu Cys Ile Ser Val 
            260                 265                 270         


Leu Leu Ala Leu Thr Val Phe Leu Leu Leu Ile Ser Lys Ile Val Pro 
        275                 280                 285             


Pro Thr Ser Leu Asp Val Pro Leu Val Gly Lys Tyr Leu Met Phe Thr 
    290                 295                 300                 


Met Val Leu Val Thr Phe Ser Ile Val Thr Ser Val Cys Val Leu Asn 
305                 310                 315                 320 


Val His His Arg Ser Pro Thr Thr His Thr Met Ala Pro Trp Val Lys 
                325                 330                 335     


Val Val Phe Leu Glu Lys Leu Pro Ala Leu Leu Phe Met Gln Gln Pro 
            340                 345                 350         


Arg His His Cys Ala Arg Gln Arg Leu Arg Leu Arg Arg Arg Gln Arg 
        355                 360                 365             


Glu Arg Glu Gly Ala Gly Ala Leu Phe Phe Arg Glu Ala Pro Gly Ala 
    370                 375                 380                 


Asp Ser Cys Thr Cys Phe Val Asn Arg Ala Ser Val Gln Gly Leu Ala 
385                 390                 395                 400 


Gly Ala Phe Gly Ala Glu Pro Ala Pro Val Ala Gly Pro Gly Arg Ser 
                405                 410                 415     


Gly Glu Pro Cys Gly Cys Gly Leu Arg Glu Ala Val Asp Gly Val Arg 
            420                 425                 430         


Phe Ile Ala Asp His Met Arg Ser Glu Asp Asp Asp Gln Ser Val Ser 
        435                 440                 445             


Glu Asp Trp Lys Tyr Val Ala Met Val Ile Asp Arg Leu Phe Leu Trp 
    450                 455                 460                 


Ile Phe Val Phe Val Cys Val Phe Gly Thr Ile Gly Met Phe Leu Gln 
465                 470                 475                 480 


Pro Leu Phe Gln Asn Tyr Thr Thr Thr Thr Phe Leu His Ser Asp His 
                485                 490                 495     


Ser Ala Pro Ser Ser Lys 
            500         


<210>  229
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  229

Met Leu Pro Asp Phe Met Leu Val Leu Ile Val Leu Gly Ile Pro Ser 
1               5                   10                  15      


Ser Ala Thr Thr Gly Phe Asn Ser Ile Ala Glu Asn Glu Asp Ala Leu 
            20                  25                  30          


Leu Arg His Leu Phe Gln Gly Tyr Gln Lys Trp Val Arg Pro Val Leu 
        35                  40                  45              


His Ser Asn Asp Thr Ile Lys Val Tyr Phe Gly Leu Lys Ile Ser Gln 
    50                  55                  60                  


Leu Val Asp Val Asp Glu Lys Asn Gln Leu Met Thr Thr Asn Val Trp 
65                  70                  75                  80  


Leu Lys Gln Glu Trp Thr Asp His Lys Leu Arg Trp Asn Pro Asp Asp 
                85                  90                  95      


Tyr Gly Gly Ile His Ser Ile Lys Val Pro Ser Glu Ser Leu Trp Leu 
            100                 105                 110         


Pro Asp Ile Val Leu Phe Glu Asn Ala Asp Gly Arg Phe Glu Gly Ser 
        115                 120                 125             


Leu Met Thr Lys Val Ile Val Lys Ser Asn Gly Thr Val Val Trp Thr 
    130                 135                 140                 


Pro Pro Ala Ser Tyr Lys Ser Ser Cys Thr Met Asp Val Thr Phe Phe 
145                 150                 155                 160 


Pro Phe Asp Arg Gln Asn Cys Ser Met Lys Phe Gly Ser Trp Thr Tyr 
                165                 170                 175     


Asp Gly Thr Met Val Asp Leu Ile Leu Ile Asn Glu Asn Val Asp Arg 
            180                 185                 190         


Lys Asp Phe Phe Asp Asn Gly Glu Trp Glu Ile Leu Asn Ala Lys Gly 
        195                 200                 205             


Met Lys Gly Asn Arg Arg Asp Gly Val Tyr Ser Tyr Pro Phe Ile Thr 
    210                 215                 220                 


Tyr Ser Phe Val Leu Arg Arg Leu Pro Leu Phe Tyr Thr Leu Phe Leu 
225                 230                 235                 240 


Ile Ile Pro Cys Leu Gly Leu Ser Phe Leu Thr Val Leu Val Phe Tyr 
                245                 250                 255     


Leu Pro Ser Asp Glu Gly Glu Lys Leu Ser Leu Ser Thr Ser Val Leu 
            260                 265                 270         


Val Ser Leu Thr Val Phe Leu Leu Val Ile Glu Glu Ile Ile Pro Ser 
        275                 280                 285             


Ser Ser Lys Val Ile Pro Leu Ile Gly Glu Tyr Leu Leu Phe Ile Met 
    290                 295                 300                 


Ile Phe Val Thr Leu Ser Ile Ile Val Thr Val Phe Val Ile Asn Val 
305                 310                 315                 320 


His His Arg Ser Ser Ser Thr Tyr His Pro Met Ala Pro Trp Val Lys 
                325                 330                 335     


Arg Leu Phe Leu Gln Lys Leu Pro Lys Leu Leu Cys Met Lys Asp His 
            340                 345                 350         


Val Asp Arg Tyr Ser Ser Pro Glu Lys Glu Glu Ser Gln Pro Val Val 
        355                 360                 365             


Lys Gly Lys Val Leu Glu Lys Lys Lys Gln Lys Gln Leu Ser Asp Gly 
    370                 375                 380                 


Glu Lys Val Leu Val Ala Phe Leu Glu Lys Ala Ala Asp Ser Ile Arg 
385                 390                 395                 400 


Tyr Ile Ser Arg His Val Lys Lys Glu His Phe Ile Ser Gln Val Val 
                405                 410                 415     


Gln Asp Trp Lys Phe Val Ala Gln Val Leu Asp Arg Ile Phe Leu Trp 
            420                 425                 430         


Leu Phe Leu Ile Val Ser Val Thr Gly Ser Val Leu Ile Phe Thr Pro 
        435                 440                 445             


Ala Leu Lys Met Trp Leu His Ser Tyr His 
    450                 455             


<210>  230
<211>  498
<212>  PRT
<213>  Homo sapiens

<400>  230

Met Arg Arg Ala Pro Ser Leu Val Leu Phe Phe Leu Val Ala Leu Cys 
1               5                   10                  15      


Gly Arg Gly Asn Cys Arg Val Ala Asn Ala Glu Glu Lys Leu Met Asp 
            20                  25                  30          


Asp Leu Leu Asn Lys Thr Arg Tyr Asn Asn Leu Ile Arg Pro Ala Thr 
        35                  40                  45              


Ser Ser Ser Gln Leu Ile Ser Ile Lys Leu Gln Leu Ser Leu Ala Gln 
    50                  55                  60                  


Leu Ile Ser Val Asn Glu Arg Glu Gln Ile Met Thr Thr Asn Val Trp 
65                  70                  75                  80  


Leu Lys Gln Glu Trp Thr Asp Tyr Arg Leu Thr Trp Asn Ser Ser Arg 
                85                  90                  95      


Tyr Glu Gly Val Asn Ile Leu Arg Ile Pro Ala Lys Arg Ile Trp Leu 
            100                 105                 110         


Pro Asp Ile Val Leu Tyr Asn Asn Ala Asp Gly Thr Tyr Glu Val Ser 
        115                 120                 125             


Val Tyr Thr Asn Leu Ile Val Arg Ser Asn Gly Ser Val Leu Trp Leu 
    130                 135                 140                 


Pro Pro Ala Ile Tyr Lys Ser Ala Cys Lys Ile Glu Val Lys Tyr Phe 
145                 150                 155                 160 


Pro Phe Asp Gln Gln Asn Cys Thr Leu Lys Phe Arg Ser Trp Thr Tyr 
                165                 170                 175     


Asp His Thr Glu Ile Asp Met Val Leu Met Thr Pro Thr Ala Ser Met 
            180                 185                 190         


Asp Asp Phe Thr Pro Ser Gly Glu Trp Asp Ile Val Ala Leu Pro Gly 
        195                 200                 205             


Arg Arg Thr Val Asn Pro Gln Asp Pro Ser Tyr Val Asp Val Thr Tyr 
    210                 215                 220                 


Asp Phe Ile Ile Lys Arg Lys Pro Leu Phe Tyr Thr Ile Asn Leu Ile 
225                 230                 235                 240 


Ile Pro Cys Val Leu Thr Thr Leu Leu Ala Ile Leu Val Phe Tyr Leu 
                245                 250                 255     


Pro Ser Asp Cys Gly Glu Lys Met Thr Leu Cys Ile Ser Val Leu Leu 
            260                 265                 270         


Ala Leu Thr Phe Phe Leu Leu Leu Ile Ser Lys Ile Val Pro Pro Thr 
        275                 280                 285             


Ser Leu Asp Val Pro Leu Ile Gly Lys Tyr Leu Met Phe Thr Met Val 
    290                 295                 300                 


Leu Val Thr Phe Ser Ile Val Thr Ser Val Cys Val Leu Asn Val His 
305                 310                 315                 320 


His Arg Ser Pro Ser Thr His Thr Met Ala Pro Trp Val Lys Arg Cys 
                325                 330                 335     


Phe Leu His Lys Leu Pro Thr Phe Leu Phe Met Lys Arg Pro Gly Pro 
            340                 345                 350         


Asp Ser Ser Pro Ala Arg Ala Phe Pro Pro Ser Lys Ser Cys Val Thr 
        355                 360                 365             


Lys Pro Glu Ala Thr Ala Thr Ser Thr Ser Pro Ser Asn Phe Tyr Gly 
    370                 375                 380                 


Asn Ser Met Tyr Phe Val Asn Pro Ala Ser Ala Ala Ser Lys Ser Pro 
385                 390                 395                 400 


Ala Gly Ser Thr Pro Val Ala Ile Pro Arg Asp Phe Trp Leu Arg Ser 
                405                 410                 415     


Ser Gly Arg Phe Arg Gln Asp Val Gln Glu Ala Leu Glu Gly Val Ser 
            420                 425                 430         


Phe Ile Ala Gln His Met Lys Asn Asp Asp Glu Asp Gln Ser Val Val 
        435                 440                 445             


Glu Asp Trp Lys Tyr Val Ala Met Val Val Asp Arg Leu Phe Leu Trp 
    450                 455                 460                 


Val Phe Met Phe Val Cys Val Leu Gly Thr Val Gly Leu Phe Leu Pro 
465                 470                 475                 480 


Pro Leu Phe Gln Thr His Ala Ala Ser Glu Gly Pro Tyr Ala Ala Gln 
                485                 490                 495     


Arg Asp 
        


<210>  231
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  231

Met Glu Gly Pro Val Leu Thr Leu Gly Leu Leu Ala Ala Leu Ala Val 
1               5                   10                  15      


Cys Gly Ser Trp Gly Leu Asn Glu Glu Glu Arg Leu Ile Arg His Leu 
            20                  25                  30          


Phe Gln Glu Lys Gly Tyr Asn Lys Glu Leu Arg Pro Val Ala His Lys 
        35                  40                  45              


Glu Glu Ser Val Asp Val Ala Leu Ala Leu Thr Leu Ser Asn Leu Ile 
    50                  55                  60                  


Ser Leu Lys Glu Val Glu Glu Thr Leu Thr Thr Asn Val Trp Ile Glu 
65                  70                  75                  80  


His Gly Trp Thr Asp Asn Arg Leu Lys Trp Asn Ala Glu Glu Phe Gly 
                85                  90                  95      


Asn Ile Ser Val Leu Arg Leu Pro Pro Asp Met Val Trp Leu Pro Glu 
            100                 105                 110         


Ile Val Leu Glu Asn Asn Asn Asp Gly Ser Phe Gln Ile Ser Tyr Ser 
        115                 120                 125             


Cys Asn Val Leu Val Tyr His Tyr Gly Phe Val Tyr Trp Leu Pro Pro 
    130                 135                 140                 


Ala Ile Phe Arg Ser Ser Cys Pro Ile Ser Val Thr Tyr Phe Pro Phe 
145                 150                 155                 160 


Asp Trp Gln Asn Cys Ser Leu Lys Phe Ser Ser Leu Lys Tyr Thr Ala 
                165                 170                 175     


Lys Glu Ile Thr Leu Ser Leu Lys Gln Asp Ala Lys Glu Asn Arg Thr 
            180                 185                 190         


Tyr Pro Val Glu Trp Ile Ile Ile Asp Pro Glu Gly Phe Thr Glu Asn 
        195                 200                 205             


Gly Glu Trp Glu Ile Val His Arg Pro Ala Arg Val Asn Val Asp Pro 
    210                 215                 220                 


Arg Ala Pro Leu Asp Ser Pro Ser Arg Gln Asp Ile Thr Phe Tyr Leu 
225                 230                 235                 240 


Ile Ile Arg Arg Lys Pro Leu Phe Tyr Ile Ile Asn Ile Leu Val Pro 
                245                 250                 255     


Cys Val Leu Ile Ser Phe Met Val Asn Leu Val Phe Tyr Leu Pro Ala 
            260                 265                 270         


Asp Ser Gly Glu Lys Thr Ser Val Ala Ile Ser Val Leu Leu Ala Gln 
        275                 280                 285             


Ser Val Phe Leu Leu Leu Ile Ser Lys Arg Leu Pro Ala Thr Ser Met 
    290                 295                 300                 


Ala Ile Pro Leu Ile Gly Lys Phe Leu Leu Phe Gly Met Val Leu Val 
305                 310                 315                 320 


Thr Met Val Val Val Ile Cys Val Ile Val Leu Asn Ile His Phe Arg 
                325                 330                 335     


Thr Pro Ser Thr His Val Leu Ser Glu Gly Val Lys Lys Leu Phe Leu 
            340                 345                 350         


Glu Thr Leu Pro Glu Leu Leu His Met Ser Arg Pro Ala Glu Asp Gly 
        355                 360                 365             


Pro Ser Pro Gly Ala Leu Val Arg Arg Ser Ser Ser Leu Gly Tyr Ile 
    370                 375                 380                 


Ser Lys Ala Glu Glu Tyr Phe Leu Leu Lys Ser Arg Ser Asp Leu Met 
385                 390                 395                 400 


Phe Glu Lys Gln Ser Glu Arg His Gly Leu Ala Arg Arg Leu Thr Thr 
                405                 410                 415     


Ala Arg Arg Pro Pro Ala Ser Ser Glu Gln Ala Gln Gln Glu Leu Phe 
            420                 425                 430         


Asn Glu Leu Lys Pro Ala Val Asp Gly Ala Asn Phe Ile Val Asn His 
        435                 440                 445             


Met Arg Asp Gln Asn Asn Tyr Asn Glu Glu Lys Asp Ser Trp Asn Arg 
    450                 455                 460                 


Val Ala Arg Thr Val Asp Arg Leu Cys Leu Phe Val Val Thr Pro Val 
465                 470                 475                 480 


Met Val Val Gly Thr Ala Trp Ile Phe Leu Gln Gly Val Tyr Asn Gln 
                485                 490                 495     


Pro Pro Pro Gln Pro Phe Pro Gly Asp Pro Tyr Ser Tyr Asn Val Gln 
            500                 505                 510         


Asp Lys Arg Phe Ile 
        515         


<210>  232
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  232

Met Pro Glu Ala Pro Pro Leu Leu Leu Ala Ala Val Leu Leu Gly Leu 
1               5                   10                  15      


Val Leu Leu Val Val Leu Leu Leu Leu Leu Arg His Trp Gly Trp Gly 
            20                  25                  30          


Leu Cys Leu Ile Gly Trp Asn Glu Phe Ile Leu Gln Pro Ile His Asn 
        35                  40                  45              


Leu Leu Met Gly Asp Thr Lys Glu Gln Arg Ile Leu Asn His Val Leu 
    50                  55                  60                  


Gln His Ala Glu Pro Gly Asn Ala Gln Ser Val Leu Glu Ala Ile Asp 
65                  70                  75                  80  


Thr Tyr Cys Glu Gln Lys Glu Trp Ala Met Asn Val Gly Asp Lys Lys 
                85                  90                  95      


Gly Lys Ile Val Asp Ala Val Ile Gln Glu His Gln Pro Ser Val Leu 
            100                 105                 110         


Leu Glu Leu Gly Ala Tyr Cys Gly Tyr Ser Ala Val Arg Met Ala Arg 
        115                 120                 125             


Leu Leu Ser Pro Gly Ala Arg Leu Ile Thr Ile Glu Ile Asn Pro Asp 
    130                 135                 140                 


Cys Ala Ala Ile Thr Gln Arg Met Val Asp Phe Ala Gly Val Lys Asp 
145                 150                 155                 160 


Lys Val Thr Leu Val Val Gly Ala Ser Gln Asp Ile Ile Pro Gln Leu 
                165                 170                 175     


Lys Lys Lys Tyr Asp Val Asp Thr Leu Asp Met Val Phe Leu Asp His 
            180                 185                 190         


Trp Lys Asp Arg Tyr Leu Pro Asp Thr Leu Leu Leu Glu Glu Cys Gly 
        195                 200                 205             


Leu Leu Arg Lys Gly Thr Val Leu Leu Ala Asp Asn Val Ile Cys Pro 
    210                 215                 220                 


Gly Ala Pro Asp Phe Leu Ala His Val Arg Gly Ser Ser Cys Phe Glu 
225                 230                 235                 240 


Cys Thr His Tyr Gln Ser Phe Leu Glu Tyr Arg Glu Val Val Asp Gly 
                245                 250                 255     


Leu Glu Lys Ala Ile Tyr Lys Gly Pro Gly Ser Glu Ala Gly Pro 
            260                 265                 270     


<210>  233
<211>  554
<212>  PRT
<213>  Homo sapiens

<400>  233

Met Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Thr Trp Leu 
1               5                   10                  15      


Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 
            20                  25                  30          


Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
        35                  40                  45              


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
    50                  55                  60                  


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
65                  70                  75                  80  


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
                85                  90                  95      


Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
            100                 105                 110         


Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 
        115                 120                 125             


Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 
    130                 135                 140                 


Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 
145                 150                 155                 160 


Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
                165                 170                 175     


Glu Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp Cys Asn Cys Leu 
            180                 185                 190         


Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser Pro His 
        195                 200                 205             


Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Thr Trp Glu 
    210                 215                 220                 


Asp Ser Glu Gly Thr Glu Gly Ser Ser Leu Leu Pro Gly Glu Gln Pro 
225                 230                 235                 240 


Leu His Thr Val Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg Ser 
                245                 250                 255     


Thr Cys Gln Ser Phe Glu Pro Pro Glu Thr Pro Val Val Lys Asp Ser 
            260                 265                 270         


Thr Ile Gly Gly Ser Pro Gln Pro Arg Pro Ser Val Gly Ala Phe Asn 
        275                 280                 285             


Pro Gly Met Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn Trp Val 
    290                 295                 300                 


Pro Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro Gln Gly 
305                 310                 315                 320 


Thr Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln Thr Glu 
                325                 330                 335     


Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro Leu Pro Ala 
            340                 345                 350         


Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Thr Gly Thr Ala Leu Pro 
        355                 360                 365             


Arg Val Gly Pro Val Arg Pro Thr Gly Gln Asp Trp Asn His Thr Pro 
    370                 375                 380                 


Gln Lys Thr Asp His Pro Ser Ala Leu Leu Arg Asp Pro Pro Glu Pro 
385                 390                 395                 400 


Gly Ser Pro Arg Ile Ser Ser Leu Arg Pro Gln Gly Leu Ser Asn Pro 
                405                 410                 415     


Ser Thr Leu Ser Ala Gln Pro Gln Leu Ser Arg Ser His Ser Ser Gly 
            420                 425                 430         


Ser Val Leu Pro Leu Gly Glu Leu Glu Gly Arg Arg Ser Thr Arg Asp 
        435                 440                 445             


Arg Arg Ser Pro Ala Glu Pro Glu Gly Gly Pro Ala Ser Glu Gly Ala 
    450                 455                 460                 


Ala Arg Pro Leu Pro Arg Phe Asn Ser Val Pro Leu Thr Asp Thr Gly 
465                 470                 475                 480 


His Glu Arg Gln Ser Glu Gly Ser Ser Ser Pro Gln Leu Gln Glu Ser 
                485                 490                 495     


Val Phe His Leu Leu Val Pro Ser Val Ile Leu Val Leu Leu Ala Val 
            500                 505                 510         


Gly Gly Leu Leu Phe Tyr Arg Trp Arg Arg Arg Ser His Gln Glu Pro 
        515                 520                 525             


Gln Arg Ala Asp Ser Pro Leu Glu Gln Pro Glu Gly Ser Pro Leu Thr 
    530                 535                 540                 


Gln Asp Asp Arg Gln Val Glu Leu Pro Val 
545                 550                 


<210>  234
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  234

Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Val Ser Glu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 
65                  70                  75                  80  


Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 
                85                  90                  95      


Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 
            100                 105                 110         


Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 
        115                 120                 125             


Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 
    130                 135                 140                 


Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 
145                 150                 155                 160 


Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 
                165                 170                 175     


Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 
            180                 185                 190         


Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
        195                 200                 205         


<210>  235
<211>  836
<212>  PRT
<213>  Homo sapiens

<400>  235

Met Ala Arg Leu Gly Asn Cys Ser Leu Thr Trp Ala Ala Leu Ile Ile 
1               5                   10                  15      


Leu Leu Leu Pro Gly Ser Leu Glu Glu Cys Gly His Ile Ser Val Ser 
            20                  25                  30          


Ala Pro Ile Val His Leu Gly Asp Pro Ile Thr Ala Ser Cys Ile Ile 
        35                  40                  45              


Lys Gln Asn Cys Ser His Leu Asp Pro Glu Pro Gln Ile Leu Trp Arg 
    50                  55                  60                  


Leu Gly Ala Glu Leu Gln Pro Gly Gly Arg Gln Gln Arg Leu Ser Asp 
65                  70                  75                  80  


Gly Thr Gln Glu Ser Ile Ile Thr Leu Pro His Leu Asn His Thr Gln 
                85                  90                  95      


Ala Phe Leu Ser Cys Cys Leu Asn Trp Gly Asn Ser Leu Gln Ile Leu 
            100                 105                 110         


Asp Gln Val Glu Leu Arg Ala Gly Tyr Pro Pro Ala Ile Pro His Asn 
        115                 120                 125             


Leu Ser Cys Leu Met Asn Leu Thr Thr Ser Ser Leu Ile Cys Gln Trp 
    130                 135                 140                 


Glu Pro Gly Pro Glu Thr His Leu Pro Thr Ser Phe Thr Leu Lys Ser 
145                 150                 155                 160 


Phe Lys Ser Arg Gly Asn Cys Gln Thr Gln Gly Asp Ser Ile Leu Asp 
                165                 170                 175     


Cys Val Pro Lys Asp Gly Gln Ser His Cys Cys Ile Pro Arg Lys His 
            180                 185                 190         


Leu Leu Leu Tyr Gln Asn Met Gly Ile Trp Val Gln Ala Glu Asn Ala 
        195                 200                 205             


Leu Gly Thr Ser Met Ser Pro Gln Leu Cys Leu Asp Pro Met Asp Val 
    210                 215                 220                 


Val Lys Leu Glu Pro Pro Met Leu Arg Thr Met Asp Pro Ser Pro Glu 
225                 230                 235                 240 


Ala Ala Pro Pro Gln Ala Gly Cys Leu Gln Leu Cys Trp Glu Pro Trp 
                245                 250                 255     


Gln Pro Gly Leu His Ile Asn Gln Lys Cys Glu Leu Arg His Lys Pro 
            260                 265                 270         


Gln Arg Gly Glu Ala Ser Trp Ala Leu Val Gly Pro Leu Pro Leu Glu 
        275                 280                 285             


Ala Leu Gln Tyr Glu Leu Cys Gly Leu Leu Pro Ala Thr Ala Tyr Thr 
    290                 295                 300                 


Leu Gln Ile Arg Cys Ile Arg Trp Pro Leu Pro Gly His Trp Ser Asp 
305                 310                 315                 320 


Trp Ser Pro Ser Leu Glu Leu Arg Thr Thr Glu Arg Ala Pro Thr Val 
                325                 330                 335     


Arg Leu Asp Thr Trp Trp Arg Gln Arg Gln Leu Asp Pro Arg Thr Val 
            340                 345                 350         


Gln Leu Phe Trp Lys Pro Val Pro Leu Glu Glu Asp Ser Gly Arg Ile 
        355                 360                 365             


Gln Gly Tyr Val Val Ser Trp Arg Pro Ser Gly Gln Ala Gly Ala Ile 
    370                 375                 380                 


Leu Pro Leu Cys Asn Thr Thr Glu Leu Ser Cys Thr Phe His Leu Pro 
385                 390                 395                 400 


Ser Glu Ala Gln Glu Val Ala Leu Val Ala Tyr Asn Ser Ala Gly Thr 
                405                 410                 415     


Ser Arg Pro Thr Pro Val Val Phe Ser Glu Ser Arg Gly Pro Ala Leu 
            420                 425                 430         


Thr Arg Leu His Ala Met Ala Arg Asp Pro His Ser Leu Trp Val Gly 
        435                 440                 445             


Trp Glu Pro Pro Asn Pro Trp Pro Gln Gly Tyr Val Ile Glu Trp Gly 
    450                 455                 460                 


Leu Gly Pro Pro Ser Ala Ser Asn Ser Asn Lys Thr Trp Arg Met Glu 
465                 470                 475                 480 


Gln Asn Gly Arg Ala Thr Gly Phe Leu Leu Lys Glu Asn Ile Arg Pro 
                485                 490                 495     


Phe Gln Leu Tyr Glu Ile Ile Val Thr Pro Leu Tyr Gln Asp Thr Met 
            500                 505                 510         


Gly Pro Ser Gln His Val Tyr Ala Tyr Ser Gln Glu Met Ala Pro Ser 
        515                 520                 525             


His Ala Pro Glu Leu His Leu Lys His Ile Gly Lys Thr Trp Ala Gln 
    530                 535                 540                 


Leu Glu Trp Val Pro Glu Pro Pro Glu Leu Gly Lys Ser Pro Leu Thr 
545                 550                 555                 560 


His Tyr Thr Ile Phe Trp Thr Asn Ala Gln Asn Gln Ser Phe Ser Ala 
                565                 570                 575     


Ile Leu Asn Ala Ser Ser Arg Gly Phe Val Leu His Gly Leu Glu Pro 
            580                 585                 590         


Ala Ser Leu Tyr His Ile His Leu Met Ala Ala Ser Gln Ala Gly Ala 
        595                 600                 605             


Thr Asn Ser Thr Val Leu Thr Leu Met Thr Leu Thr Pro Glu Gly Ser 
    610                 615                 620                 


Glu Leu His Ile Ile Leu Gly Leu Phe Gly Leu Leu Leu Leu Leu Thr 
625                 630                 635                 640 


Cys Leu Cys Gly Thr Ala Trp Leu Cys Cys Ser Pro Asn Arg Lys Asn 
                645                 650                 655     


Pro Leu Trp Pro Ser Val Pro Asp Pro Ala His Ser Ser Leu Gly Ser 
            660                 665                 670         


Trp Val Pro Thr Ile Met Glu Glu Asp Ala Phe Gln Leu Pro Gly Leu 
        675                 680                 685             


Gly Thr Pro Pro Ile Thr Lys Leu Thr Val Leu Glu Glu Asp Glu Lys 
    690                 695                 700                 


Lys Pro Val Pro Trp Glu Ser His Asn Ser Ser Glu Thr Cys Gly Leu 
705                 710                 715                 720 


Pro Thr Leu Val Gln Thr Tyr Val Leu Gln Gly Asp Pro Arg Ala Val 
                725                 730                 735     


Ser Thr Gln Pro Gln Ser Gln Ser Gly Thr Ser Asp Gln Val Leu Tyr 
            740                 745                 750         


Gly Gln Leu Leu Gly Ser Pro Thr Ser Pro Gly Pro Gly His Tyr Leu 
        755                 760                 765             


Arg Cys Asp Ser Thr Gln Pro Leu Leu Ala Gly Leu Thr Pro Ser Pro 
    770                 775                 780                 


Lys Ser Tyr Glu Asn Leu Trp Phe Gln Ala Ser Pro Leu Gly Thr Leu 
785                 790                 795                 800 


Val Thr Pro Ala Pro Ser Gln Glu Asp Asp Cys Val Phe Gly Pro Leu 
                805                 810                 815     


Leu Asn Phe Pro Leu Leu Gln Gly Ile Arg Val His Gly Met Glu Ala 
            820                 825                 830         


Leu Gly Ser Phe 
        835     


<210>  236
<211>  516
<212>  PRT
<213>  Homo sapiens

<400>  236

Met Ala Leu Ser Gln Ser Val Pro Phe Ser Ala Thr Glu Leu Leu Leu 
1               5                   10                  15      


Ala Ser Ala Ile Phe Cys Leu Val Phe Trp Val Leu Lys Gly Leu Arg 
            20                  25                  30          


Pro Arg Val Pro Lys Gly Leu Lys Ser Pro Pro Glu Pro Trp Gly Trp 
        35                  40                  45              


Pro Leu Leu Gly His Val Leu Thr Leu Gly Lys Asn Pro His Leu Ala 
    50                  55                  60                  


Leu Ser Arg Met Ser Gln Arg Tyr Gly Asp Val Leu Gln Ile Arg Ile 
65                  70                  75                  80  


Gly Ser Thr Pro Val Leu Val Leu Ser Arg Leu Asp Thr Ile Arg Gln 
                85                  90                  95      


Ala Leu Val Arg Gln Gly Asp Asp Phe Lys Gly Arg Pro Asp Leu Tyr 
            100                 105                 110         


Thr Ser Thr Leu Ile Thr Asp Gly Gln Ser Leu Thr Phe Ser Thr Asp 
        115                 120                 125             


Ser Gly Pro Val Trp Ala Ala Arg Arg Arg Leu Ala Gln Asn Ala Leu 
    130                 135                 140                 


Asn Thr Phe Ser Ile Ala Ser Asp Pro Ala Ser Ser Ser Ser Cys Tyr 
145                 150                 155                 160 


Leu Glu Glu His Val Ser Lys Glu Ala Lys Ala Leu Ile Ser Arg Leu 
                165                 170                 175     


Gln Glu Leu Met Ala Gly Pro Gly His Phe Asp Pro Tyr Asn Gln Val 
            180                 185                 190         


Val Val Ser Val Ala Asn Val Ile Gly Ala Met Cys Phe Gly Gln His 
        195                 200                 205             


Phe Pro Glu Ser Ser Asp Glu Met Leu Ser Leu Val Lys Asn Thr His 
    210                 215                 220                 


Glu Phe Val Glu Thr Ala Ser Ser Gly Asn Pro Leu Asp Phe Phe Pro 
225                 230                 235                 240 


Ile Leu Arg Tyr Leu Pro Asn Pro Ala Leu Gln Arg Phe Lys Ala Phe 
                245                 250                 255     


Asn Gln Arg Phe Leu Trp Phe Leu Gln Lys Thr Val Gln Glu His Tyr 
            260                 265                 270         


Gln Asp Phe Asp Lys Asn Ser Val Arg Asp Ile Thr Gly Ala Leu Phe 
        275                 280                 285             


Lys His Ser Lys Lys Gly Pro Arg Ala Ser Gly Asn Leu Ile Pro Gln 
    290                 295                 300                 


Glu Lys Ile Val Asn Leu Val Asn Asp Ile Phe Gly Ala Gly Phe Asp 
305                 310                 315                 320 


Thr Val Thr Thr Ala Ile Ser Trp Ser Leu Met Tyr Leu Val Thr Lys 
                325                 330                 335     


Pro Glu Ile Gln Arg Lys Ile Gln Lys Glu Leu Asp Thr Val Ile Gly 
            340                 345                 350         


Arg Glu Arg Arg Pro Arg Leu Ser Asp Arg Pro Gln Leu Pro Tyr Leu 
        355                 360                 365             


Glu Ala Phe Ile Leu Glu Thr Phe Arg His Ser Ser Phe Leu Pro Phe 
    370                 375                 380                 


Thr Ile Pro His Ser Thr Thr Arg Asp Thr Thr Leu Asn Gly Phe Tyr 
385                 390                 395                 400 


Ile Pro Lys Lys Cys Cys Val Phe Val Asn Gln Trp Gln Val Asn His 
                405                 410                 415     


Asp Pro Glu Leu Trp Glu Asp Pro Ser Glu Phe Arg Pro Glu Arg Phe 
            420                 425                 430         


Leu Thr Ala Asp Gly Thr Ala Ile Asn Lys Pro Leu Ser Glu Lys Met 
        435                 440                 445             


Met Leu Phe Gly Met Gly Lys Arg Arg Cys Ile Gly Glu Val Leu Ala 
    450                 455                 460                 


Lys Trp Glu Ile Phe Leu Phe Leu Ala Ile Leu Leu Gln Gln Leu Glu 
465                 470                 475                 480 


Phe Ser Val Pro Pro Gly Val Lys Val Asp Leu Thr Pro Ile Tyr Gly 
                485                 490                 495     


Leu Thr Met Lys His Ala Arg Cys Glu His Val Gln Ala Arg Leu Arg 
            500                 505                 510         


Phe Ser Ile Asn 
        515     


<210>  237
<211>  494
<212>  PRT
<213>  Homo sapiens

<400>  237

Met Leu Ala Ser Gly Met Leu Leu Val Ala Leu Leu Val Cys Leu Thr 
1               5                   10                  15      


Val Met Val Leu Met Ser Val Trp Gln Gln Arg Lys Ser Lys Gly Lys 
            20                  25                  30          


Leu Pro Pro Gly Pro Thr Pro Leu Pro Phe Ile Gly Asn Tyr Leu Gln 
        35                  40                  45              


Leu Asn Thr Glu Gln Met Tyr Asn Ser Leu Met Lys Ile Ser Glu Arg 
    50                  55                  60                  


Tyr Gly Pro Val Phe Thr Ile His Leu Gly Pro Arg Arg Val Val Val 
65                  70                  75                  80  


Leu Cys Gly His Asp Ala Val Arg Glu Ala Leu Val Asp Gln Ala Glu 
                85                  90                  95      


Glu Phe Ser Gly Arg Gly Glu Gln Ala Thr Phe Asp Trp Val Phe Lys 
            100                 105                 110         


Gly Tyr Gly Val Val Phe Ser Asn Gly Glu Arg Ala Lys Gln Leu Arg 
        115                 120                 125             


Arg Phe Ser Ile Ala Thr Leu Arg Asp Phe Gly Val Gly Lys Arg Gly 
    130                 135                 140                 


Ile Glu Glu Arg Ile Gln Glu Glu Ala Gly Phe Leu Ile Asp Ala Leu 
145                 150                 155                 160 


Arg Gly Thr Gly Gly Ala Asn Ile Asp Pro Thr Phe Phe Leu Ser Arg 
                165                 170                 175     


Thr Val Ser Asn Val Ile Ser Ser Ile Val Phe Gly Asp Arg Phe Asp 
            180                 185                 190         


Tyr Lys Asp Lys Glu Phe Leu Ser Leu Leu Arg Met Met Leu Gly Ile 
        195                 200                 205             


Phe Gln Phe Thr Ser Thr Ser Thr Gly Gln Leu Tyr Glu Met Phe Ser 
    210                 215                 220                 


Ser Val Met Lys His Leu Pro Gly Pro Gln Gln Gln Ala Phe Gln Leu 
225                 230                 235                 240 


Leu Gln Gly Leu Glu Asp Phe Ile Ala Lys Lys Val Glu His Asn Gln 
                245                 250                 255     


Arg Thr Leu Asp Pro Asn Ser Pro Arg Asp Phe Ile Asp Ser Phe Leu 
            260                 265                 270         


Ile Arg Met Gln Glu Glu Glu Lys Asn Pro Asn Thr Glu Phe Tyr Leu 
        275                 280                 285             


Lys Asn Leu Val Met Thr Thr Leu Asn Leu Phe Ile Gly Gly Thr Glu 
    290                 295                 300                 


Thr Val Ser Thr Thr Leu Arg Tyr Gly Phe Leu Leu Leu Met Lys His 
305                 310                 315                 320 


Pro Glu Val Glu Ala Lys Val His Glu Glu Ile Asp Arg Val Ile Gly 
                325                 330                 335     


Lys Asn Arg Gln Pro Lys Phe Glu Asp Arg Ala Lys Met Pro Tyr Met 
            340                 345                 350         


Glu Ala Val Ile His Glu Ile Gln Arg Phe Gly Asp Val Ile Pro Met 
        355                 360                 365             


Ser Leu Ala Arg Arg Val Lys Lys Asp Thr Lys Phe Arg Asp Phe Phe 
    370                 375                 380                 


Leu Pro Lys Gly Thr Glu Val Tyr Pro Met Leu Gly Ser Val Leu Arg 
385                 390                 395                 400 


Asp Pro Ser Phe Phe Ser Asn Pro Gln Asp Phe Asn Pro Gln His Phe 
                405                 410                 415     


Leu Asn Glu Lys Gly Gln Phe Lys Lys Ser Asp Ala Phe Val Pro Phe 
            420                 425                 430         


Ser Ile Gly Lys Arg Asn Cys Phe Gly Glu Gly Leu Ala Arg Met Glu 
        435                 440                 445             


Leu Phe Leu Phe Phe Thr Thr Val Met Gln Asn Phe Arg Leu Lys Ser 
    450                 455                 460                 


Ser Gln Ser Pro Lys Asp Ile Asp Val Ser Pro Lys His Val Gly Phe 
465                 470                 475                 480 


Ala Thr Ile Pro Arg Asn Tyr Thr Met Ser Phe Leu Pro Arg 
                485                 490                 


<210>  238
<211>  494
<212>  PRT
<213>  Homo sapiens

<400>  238

Met Leu Ala Ser Gly Leu Leu Leu Val Ala Leu Leu Ala Cys Leu Thr 
1               5                   10                  15      


Val Met Val Leu Met Ser Val Trp Gln Gln Arg Lys Ser Arg Gly Lys 
            20                  25                  30          


Leu Pro Pro Gly Pro Thr Pro Leu Pro Phe Ile Gly Asn Tyr Leu Gln 
        35                  40                  45              


Leu Asn Thr Glu His Ile Cys Asp Ser Ile Met Lys Phe Ser Glu Cys 
    50                  55                  60                  


Tyr Gly Pro Val Phe Thr Ile His Leu Gly Pro Arg Arg Val Val Val 
65                  70                  75                  80  


Leu Cys Gly His Asp Ala Val Arg Glu Ala Leu Val Asp Gln Ala Glu 
                85                  90                  95      


Glu Phe Ser Gly Arg Gly Glu Gln Ala Thr Phe Asp Trp Val Phe Lys 
            100                 105                 110         


Gly Tyr Gly Val Ala Phe Ser Asn Gly Glu Arg Ala Lys Gln Leu Leu 
        115                 120                 125             


Arg Phe Ala Ile Ala Thr Leu Arg Asp Phe Gly Val Gly Lys Arg Gly 
    130                 135                 140                 


Ile Glu Glu Arg Ile Gln Glu Glu Ser Gly Phe Leu Ile Glu Ala Ile 
145                 150                 155                 160 


Arg Ser Thr His Gly Ala Asn Ile Asp Pro Thr Phe Phe Leu Ser Arg 
                165                 170                 175     


Thr Val Ser Asn Val Ile Ser Ser Ile Val Phe Gly Asp Arg Phe Asp 
            180                 185                 190         


Tyr Glu Asp Lys Glu Phe Leu Ser Leu Leu Ser Met Met Leu Gly Ile 
        195                 200                 205             


Phe Gln Phe Thr Ser Thr Ser Thr Gly Gln Leu Tyr Glu Met Phe Ser 
    210                 215                 220                 


Ser Val Met Lys His Leu Pro Gly Pro Gln Gln Gln Ala Phe Lys Leu 
225                 230                 235                 240 


Leu Gln Gly Leu Glu Asp Phe Ile Ala Lys Lys Val Glu His Asn Gln 
                245                 250                 255     


Arg Thr Leu Asp Pro Asn Ser Pro Gln Asp Phe Ile Asp Ser Phe Leu 
            260                 265                 270         


Ile His Met Gln Glu Glu Glu Lys Asn Pro Asn Thr Glu Phe Tyr Leu 
        275                 280                 285             


Lys Asn Leu Met Met Ser Thr Leu Asn Leu Phe Ile Ala Gly Thr Glu 
    290                 295                 300                 


Thr Val Ser Thr Thr Leu Arg Tyr Gly Phe Leu Leu Leu Met Lys His 
305                 310                 315                 320 


Pro Glu Val Glu Ala Lys Val His Glu Glu Ile Asp Arg Val Ile Gly 
                325                 330                 335     


Lys Asn Arg Gln Pro Lys Phe Glu Asp Arg Thr Lys Met Pro Tyr Met 
            340                 345                 350         


Glu Ala Val Ile His Glu Ile Gln Arg Phe Gly Asp Val Ile Pro Met 
        355                 360                 365             


Ser Leu Ala Arg Arg Val Lys Lys Asp Thr Lys Phe Arg Asp Phe Phe 
    370                 375                 380                 


Leu Pro Lys Gly Thr Glu Val Phe Pro Met Leu Gly Ser Val Leu Arg 
385                 390                 395                 400 


Asp Pro Ser Phe Phe Ser Asn Pro Gln Asp Phe Asn Pro Gln His Phe 
                405                 410                 415     


Leu Asp Asp Lys Gly Gln Phe Lys Lys Ser Asp Ala Phe Val Pro Phe 
            420                 425                 430         


Ser Ile Gly Lys Arg Asn Cys Phe Gly Glu Gly Leu Ala Arg Met Glu 
        435                 440                 445             


Leu Phe Leu Phe Phe Thr Thr Val Met Gln Asn Phe Arg Leu Lys Ser 
    450                 455                 460                 


Ser Gln Ser Pro Lys Asp Ile Asp Val Ser Pro Lys His Val Val Phe 
465                 470                 475                 480 


Ala Thr Ile Pro Arg Asn Tyr Thr Met Ser Phe Leu Pro Arg 
                485                 490                 


<210>  239
<211>  503
<212>  PRT
<213>  Homo sapiens

<400>  239

Met Asp Leu Ile Pro Asn Leu Ala Val Glu Thr Trp Leu Leu Leu Ala 
1               5                   10                  15      


Val Ser Leu Ile Leu Leu Tyr Leu Tyr Gly Thr Arg Thr His Gly Leu 
            20                  25                  30          


Phe Lys Lys Leu Gly Ile Pro Gly Pro Thr Pro Leu Pro Phe Leu Gly 
        35                  40                  45              


Asn Ala Leu Ser Phe Arg Lys Gly Tyr Trp Thr Phe Asp Met Glu Cys 
    50                  55                  60                  


Tyr Lys Lys Tyr Arg Lys Val Trp Gly Ile Tyr Asp Cys Gln Gln Pro 
65                  70                  75                  80  


Met Leu Ala Ile Thr Asp Pro Asp Met Ile Lys Thr Val Leu Val Lys 
                85                  90                  95      


Glu Cys Tyr Ser Val Phe Thr Asn Arg Arg Pro Phe Gly Pro Val Gly 
            100                 105                 110         


Phe Met Lys Asn Ala Ile Ser Ile Ala Glu Asp Glu Glu Trp Lys Arg 
        115                 120                 125             


Ile Arg Ser Leu Leu Ser Pro Thr Phe Thr Ser Gly Lys Leu Lys Glu 
    130                 135                 140                 


Met Val Pro Ile Ile Ala Gln Tyr Gly Asp Val Leu Val Arg Asn Leu 
145                 150                 155                 160 


Arg Arg Glu Ala Glu Thr Gly Lys Pro Val Thr Leu Lys His Val Phe 
                165                 170                 175     


Gly Ala Tyr Ser Met Asp Val Ile Thr Ser Thr Ser Phe Gly Val Ser 
            180                 185                 190         


Ile Asp Ser Leu Asn Asn Pro Gln Asp Pro Phe Val Glu Asn Thr Lys 
        195                 200                 205             


Lys Leu Leu Arg Phe Asn Pro Leu Asp Pro Phe Val Leu Ser Ile Lys 
    210                 215                 220                 


Val Phe Pro Phe Leu Thr Pro Ile Leu Glu Ala Leu Asn Ile Thr Val 
225                 230                 235                 240 


Phe Pro Arg Lys Val Ile Ser Phe Leu Thr Lys Ser Val Lys Gln Ile 
                245                 250                 255     


Lys Glu Gly Arg Leu Lys Glu Thr Gln Lys His Arg Val Asp Phe Leu 
            260                 265                 270         


Gln Leu Met Ile Asp Ser Gln Asn Ser Lys Asp Ser Glu Thr His Lys 
        275                 280                 285             


Ala Leu Ser Asp Leu Glu Leu Met Ala Gln Ser Ile Ile Phe Ile Phe 
    290                 295                 300                 


Ala Gly Tyr Glu Thr Thr Ser Ser Val Leu Ser Phe Ile Ile Tyr Glu 
305                 310                 315                 320 


Leu Ala Thr His Pro Asp Val Gln Gln Lys Val Gln Lys Glu Ile Asp 
                325                 330                 335     


Thr Val Leu Pro Asn Lys Ala Pro Pro Thr Tyr Asp Thr Val Leu Gln 
            340                 345                 350         


Leu Glu Tyr Leu Asp Met Val Val Asn Glu Thr Leu Arg Leu Phe Pro 
        355                 360                 365             


Val Ala Met Arg Leu Glu Arg Val Cys Lys Lys Asp Val Glu Ile Asn 
    370                 375                 380                 


Gly Met Phe Ile Pro Lys Gly Val Val Val Met Ile Pro Ser Tyr Val 
385                 390                 395                 400 


Leu His His Asp Pro Lys Tyr Trp Thr Glu Pro Glu Lys Phe Leu Pro 
                405                 410                 415     


Glu Arg Phe Ser Lys Lys Asn Lys Asp Asn Ile Asp Pro Tyr Ile Tyr 
            420                 425                 430         


Thr Pro Phe Gly Ser Gly Pro Arg Asn Cys Ile Gly Met Arg Phe Ala 
        435                 440                 445             


Leu Val Asn Met Lys Leu Ala Leu Val Arg Val Leu Gln Asn Phe Ser 
    450                 455                 460                 


Phe Lys Pro Cys Lys Glu Thr Gln Ile Pro Leu Lys Leu Arg Phe Gly 
465                 470                 475                 480 


Gly Leu Leu Leu Thr Glu Lys Pro Ile Val Leu Lys Ala Glu Ser Arg 
                485                 490                 495     


Asp Glu Thr Val Ser Gly Ala 
            500             


<210>  240
<211>  494
<212>  PRT
<213>  Homo sapiens

<400>  240

Met Leu Ala Ser Gly Leu Leu Leu Val Thr Leu Leu Ala Cys Leu Thr 
1               5                   10                  15      


Val Met Val Leu Met Ser Val Trp Arg Gln Arg Lys Ser Arg Gly Lys 
            20                  25                  30          


Leu Pro Pro Gly Pro Thr Pro Leu Pro Phe Ile Gly Asn Tyr Leu Gln 
        35                  40                  45              


Leu Asn Thr Glu Gln Met Tyr Asn Ser Leu Met Lys Ile Ser Glu Arg 
    50                  55                  60                  


Tyr Gly Pro Val Phe Thr Ile His Leu Gly Pro Arg Arg Val Val Val 
65                  70                  75                  80  


Leu Cys Gly His Asp Ala Val Lys Glu Ala Leu Val Asp Gln Ala Glu 
                85                  90                  95      


Glu Phe Ser Gly Arg Gly Glu Gln Ala Thr Phe Asp Trp Leu Phe Lys 
            100                 105                 110         


Gly Tyr Gly Val Ala Phe Ser Asn Gly Glu Arg Ala Lys Gln Leu Arg 
        115                 120                 125             


Arg Phe Ser Ile Ala Thr Leu Arg Gly Phe Gly Val Gly Lys Arg Gly 
    130                 135                 140                 


Ile Glu Glu Arg Ile Gln Glu Glu Ala Gly Phe Leu Ile Asp Ala Leu 
145                 150                 155                 160 


Arg Gly Thr His Gly Ala Asn Ile Asp Pro Thr Phe Phe Leu Ser Arg 
                165                 170                 175     


Thr Val Ser Asn Val Ile Ser Ser Ile Val Phe Gly Asp Arg Phe Asp 
            180                 185                 190         


Tyr Glu Asp Lys Glu Phe Leu Ser Leu Leu Arg Met Met Leu Gly Ser 
        195                 200                 205             


Phe Gln Phe Thr Ala Thr Ser Thr Gly Gln Leu Tyr Glu Met Phe Ser 
    210                 215                 220                 


Ser Val Met Lys His Leu Pro Gly Pro Gln Gln Gln Ala Phe Lys Glu 
225                 230                 235                 240 


Leu Gln Gly Leu Glu Asp Phe Ile Ala Lys Lys Val Glu His Asn Gln 
                245                 250                 255     


Arg Thr Leu Asp Pro Asn Ser Pro Arg Asp Phe Ile Asp Ser Phe Leu 
            260                 265                 270         


Ile Arg Met Gln Glu Glu Glu Lys Asn Pro Asn Thr Glu Phe Tyr Leu 
        275                 280                 285             


Lys Asn Leu Val Met Thr Thr Leu Asn Leu Phe Phe Ala Gly Thr Glu 
    290                 295                 300                 


Thr Val Ser Thr Thr Leu Arg Tyr Gly Phe Leu Leu Leu Met Lys His 
305                 310                 315                 320 


Pro Glu Val Glu Ala Lys Val His Glu Glu Ile Asp Arg Val Ile Gly 
                325                 330                 335     


Lys Asn Arg Gln Pro Lys Phe Glu Asp Arg Ala Lys Met Pro Tyr Thr 
            340                 345                 350         


Glu Ala Val Ile His Glu Ile Gln Arg Phe Gly Asp Met Leu Pro Met 
        355                 360                 365             


Gly Leu Ala His Arg Val Asn Lys Asp Thr Lys Phe Arg Asp Phe Phe 
    370                 375                 380                 


Leu Pro Lys Gly Thr Glu Val Phe Pro Met Leu Gly Ser Val Leu Arg 
385                 390                 395                 400 


Asp Pro Arg Phe Phe Ser Asn Pro Arg Asp Phe Asn Pro Gln His Phe 
                405                 410                 415     


Leu Asp Lys Lys Gly Gln Phe Lys Lys Ser Asp Ala Phe Val Pro Phe 
            420                 425                 430         


Ser Ile Gly Lys Arg Tyr Cys Phe Gly Glu Gly Leu Ala Arg Met Glu 
        435                 440                 445             


Leu Phe Leu Phe Phe Thr Thr Ile Met Gln Asn Phe Arg Phe Lys Ser 
    450                 455                 460                 


Pro Gln Ser Pro Lys Asp Ile Asp Val Ser Pro Lys His Val Gly Phe 
465                 470                 475                 480 


Ala Thr Ile Pro Arg Asn Tyr Thr Met Ser Phe Leu Pro Arg 
                485                 490                 


<210>  241
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  241

Met Glu Pro Phe Val Val Leu Val Leu Cys Leu Ser Phe Met Leu Leu 
1               5                   10                  15      


Phe Ser Leu Trp Arg Gln Ser Cys Arg Arg Arg Lys Leu Pro Pro Gly 
            20                  25                  30          


Pro Thr Pro Leu Pro Ile Ile Gly Asn Met Leu Gln Ile Asp Val Lys 
        35                  40                  45              


Asp Ile Cys Lys Ser Phe Thr Asn Phe Ser Lys Val Tyr Gly Pro Val 
    50                  55                  60                  


Phe Thr Val Tyr Phe Gly Met Asn Pro Ile Val Val Phe His Gly Tyr 
65                  70                  75                  80  


Glu Ala Val Lys Glu Ala Leu Ile Asp Asn Gly Glu Glu Phe Ser Gly 
                85                  90                  95      


Arg Gly Asn Ser Pro Ile Ser Gln Arg Ile Thr Lys Gly Leu Gly Ile 
            100                 105                 110         


Ile Ser Ser Asn Gly Lys Arg Trp Lys Glu Ile Arg Arg Phe Ser Leu 
        115                 120                 125             


Thr Thr Leu Arg Asn Phe Gly Met Gly Lys Arg Ser Ile Glu Asp Arg 
    130                 135                 140                 


Val Gln Glu Glu Ala His Cys Leu Val Glu Glu Leu Arg Lys Thr Lys 
145                 150                 155                 160 


Ala Ser Pro Cys Asp Pro Thr Phe Ile Leu Gly Cys Ala Pro Cys Asn 
                165                 170                 175     


Val Ile Cys Ser Val Val Phe Gln Lys Arg Phe Asp Tyr Lys Asp Gln 
            180                 185                 190         


Asn Phe Leu Thr Leu Met Lys Arg Phe Asn Glu Asn Phe Arg Ile Leu 
        195                 200                 205             


Asn Ser Pro Trp Ile Gln Val Cys Asn Asn Phe Pro Leu Leu Ile Asp 
    210                 215                 220                 


Cys Phe Pro Gly Thr His Asn Lys Val Leu Lys Asn Val Ala Leu Thr 
225                 230                 235                 240 


Arg Ser Tyr Ile Arg Glu Lys Val Lys Glu His Gln Ala Ser Leu Asp 
                245                 250                 255     


Val Asn Asn Pro Arg Asp Phe Ile Asp Cys Phe Leu Ile Lys Met Glu 
            260                 265                 270         


Gln Glu Lys Asp Asn Gln Lys Ser Glu Phe Asn Ile Glu Asn Leu Val 
        275                 280                 285             


Gly Thr Val Ala Asp Leu Phe Val Ala Gly Thr Glu Thr Thr Ser Thr 
    290                 295                 300                 


Thr Leu Arg Tyr Gly Leu Leu Leu Leu Leu Lys His Pro Glu Val Thr 
305                 310                 315                 320 


Ala Lys Val Gln Glu Glu Ile Asp His Val Ile Gly Arg His Arg Ser 
                325                 330                 335     


Pro Cys Met Gln Asp Arg Ser His Met Pro Tyr Thr Asp Ala Val Val 
            340                 345                 350         


His Glu Ile Gln Arg Tyr Ser Asp Leu Val Pro Thr Gly Val Pro His 
        355                 360                 365             


Ala Val Thr Thr Asp Thr Lys Phe Arg Asn Tyr Leu Ile Pro Lys Gly 
    370                 375                 380                 


Thr Thr Ile Met Ala Leu Leu Thr Ser Val Leu His Asp Asp Lys Glu 
385                 390                 395                 400 


Phe Pro Asn Pro Asn Ile Phe Asp Pro Gly His Phe Leu Asp Lys Asn 
                405                 410                 415     


Gly Asn Phe Lys Lys Ser Asp Tyr Phe Met Pro Phe Ser Ala Gly Lys 
            420                 425                 430         


Arg Ile Cys Ala Gly Glu Gly Leu Ala Arg Met Glu Leu Phe Leu Phe 
        435                 440                 445             


Leu Thr Thr Ile Leu Gln Asn Phe Asn Leu Lys Ser Val Asp Asp Leu 
    450                 455                 460                 


Lys Asn Leu Asn Thr Thr Ala Val Thr Lys Gly Ile Val Ser Leu Pro 
465                 470                 475                 480 


Pro Ser Tyr Gln Ile Cys Phe Ile Pro Val 
                485                 490 


<210>  242
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  242

Met Ser Ala Leu Gly Val Thr Val Ala Leu Leu Val Trp Ala Ala Phe 
1               5                   10                  15      


Leu Leu Leu Val Ser Met Trp Arg Gln Val His Ser Ser Trp Asn Leu 
            20                  25                  30          


Pro Pro Gly Pro Phe Pro Leu Pro Ile Ile Gly Asn Leu Phe Gln Leu 
        35                  40                  45              


Glu Leu Lys Asn Ile Pro Lys Ser Phe Thr Arg Leu Ala Gln Arg Phe 
    50                  55                  60                  


Gly Pro Val Phe Thr Leu Tyr Val Gly Ser Gln Arg Met Val Val Met 
65                  70                  75                  80  


His Gly Tyr Lys Ala Val Lys Glu Ala Leu Leu Asp Tyr Lys Asp Glu 
                85                  90                  95      


Phe Ser Gly Arg Gly Asp Leu Pro Ala Phe His Ala His Arg Asp Arg 
            100                 105                 110         


Gly Ile Ile Phe Asn Asn Gly Pro Thr Trp Lys Asp Ile Arg Arg Phe 
        115                 120                 125             


Ser Leu Thr Thr Leu Arg Asn Tyr Gly Met Gly Lys Gln Gly Asn Glu 
    130                 135                 140                 


Ser Arg Ile Gln Arg Glu Ala His Phe Leu Leu Glu Ala Leu Arg Lys 
145                 150                 155                 160 


Thr Gln Gly Gln Pro Phe Asp Pro Thr Phe Leu Ile Gly Cys Ala Pro 
                165                 170                 175     


Cys Asn Val Ile Ala Asp Ile Leu Phe Arg Lys His Phe Asp Tyr Asn 
            180                 185                 190         


Asp Glu Lys Phe Leu Arg Leu Met Tyr Leu Phe Asn Glu Asn Phe His 
        195                 200                 205             


Leu Leu Ser Thr Pro Trp Leu Gln Leu Tyr Asn Asn Phe Pro Ser Phe 
    210                 215                 220                 


Leu His Tyr Leu Pro Gly Ser His Arg Lys Val Ile Lys Asn Val Ala 
225                 230                 235                 240 


Glu Val Lys Glu Tyr Val Ser Glu Arg Val Lys Glu His His Gln Ser 
                245                 250                 255     


Leu Asp Pro Asn Cys Pro Arg Asp Leu Thr Asp Cys Leu Leu Val Glu 
            260                 265                 270         


Met Glu Lys Glu Lys His Ser Ala Glu Arg Leu Tyr Thr Met Asp Gly 
        275                 280                 285             


Ile Thr Val Thr Val Ala Asp Leu Phe Phe Ala Gly Thr Glu Thr Thr 
    290                 295                 300                 


Ser Thr Thr Leu Arg Tyr Gly Leu Leu Ile Leu Met Lys Tyr Pro Glu 
305                 310                 315                 320 


Ile Glu Glu Lys Leu His Glu Glu Ile Asp Arg Val Ile Gly Pro Ser 
                325                 330                 335     


Arg Ile Pro Ala Ile Lys Asp Arg Gln Glu Met Pro Tyr Met Asp Ala 
            340                 345                 350         


Val Val His Glu Ile Gln Arg Phe Ile Thr Leu Val Pro Ser Asn Leu 
        355                 360                 365             


Pro His Glu Ala Thr Arg Asp Thr Ile Phe Arg Gly Tyr Leu Ile Pro 
    370                 375                 380                 


Lys Gly Thr Val Val Val Pro Thr Leu Asp Ser Val Leu Tyr Asp Asn 
385                 390                 395                 400 


Gln Glu Phe Pro Asp Pro Glu Lys Phe Lys Pro Glu His Phe Leu Asn 
                405                 410                 415     


Glu Asn Gly Lys Phe Lys Tyr Ser Asp Tyr Phe Lys Pro Phe Ser Thr 
            420                 425                 430         


Gly Lys Arg Val Cys Ala Gly Glu Gly Leu Ala Arg Met Glu Leu Phe 
        435                 440                 445             


Leu Leu Leu Cys Ala Ile Leu Gln His Phe Asn Leu Lys Pro Leu Val 
    450                 455                 460                 


Asp Pro Lys Asp Ile Asp Leu Ser Pro Ile His Ile Gly Phe Gly Cys 
465                 470                 475                 480 


Ile Pro Pro Arg Tyr Lys Leu Cys Val Ile Pro Arg Ser 
                485                 490             


<210>  243
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  243

Met Leu Ala Ala Met Gly Ser Leu Ala Ala Ala Leu Trp Ala Val Val 
1               5                   10                  15      


His Pro Arg Thr Leu Leu Leu Gly Thr Val Ala Phe Leu Leu Ala Ala 
            20                  25                  30          


Asp Phe Leu Lys Arg Arg Arg Pro Lys Asn Tyr Pro Pro Gly Pro Trp 
        35                  40                  45              


Arg Leu Pro Phe Leu Gly Asn Phe Phe Leu Val Asp Phe Glu Gln Ser 
    50                  55                  60                  


His Leu Glu Val Gln Leu Phe Val Lys Lys Tyr Gly Asn Leu Phe Ser 
65                  70                  75                  80  


Leu Glu Leu Gly Asp Ile Ser Ala Val Leu Ile Thr Gly Leu Pro Leu 
                85                  90                  95      


Ile Lys Glu Ala Leu Ile His Met Asp Gln Asn Phe Gly Asn Arg Pro 
            100                 105                 110         


Val Thr Pro Met Arg Glu His Ile Phe Lys Lys Asn Gly Leu Ile Met 
        115                 120                 125             


Ser Ser Gly Gln Ala Trp Lys Glu Gln Arg Arg Phe Thr Leu Thr Ala 
    130                 135                 140                 


Leu Arg Asn Phe Gly Leu Gly Lys Lys Ser Leu Glu Glu Arg Ile Gln 
145                 150                 155                 160 


Glu Glu Ala Gln His Leu Thr Glu Ala Ile Lys Glu Glu Asn Gly Gln 
                165                 170                 175     


Pro Phe Asp Pro His Phe Lys Ile Asn Asn Ala Val Ser Asn Ile Ile 
            180                 185                 190         


Cys Ser Ile Thr Phe Gly Glu Arg Phe Glu Tyr Gln Asp Ser Trp Phe 
        195                 200                 205             


Gln Gln Leu Leu Lys Leu Leu Asp Glu Val Thr Tyr Leu Glu Ala Ser 
    210                 215                 220                 


Lys Thr Cys Gln Leu Tyr Asn Val Phe Pro Trp Ile Met Lys Phe Leu 
225                 230                 235                 240 


Pro Gly Pro His Gln Thr Leu Phe Ser Asn Trp Lys Lys Leu Lys Leu 
                245                 250                 255     


Phe Val Ser His Met Ile Asp Lys His Arg Lys Asp Trp Asn Pro Ala 
            260                 265                 270         


Glu Thr Arg Asp Phe Ile Asp Ala Tyr Leu Lys Glu Met Ser Lys His 
        275                 280                 285             


Thr Gly Asn Pro Thr Ser Ser Phe His Glu Glu Asn Leu Ile Cys Ser 
    290                 295                 300                 


Thr Leu Asp Leu Phe Phe Ala Gly Thr Glu Thr Thr Ser Thr Thr Leu 
305                 310                 315                 320 


Arg Trp Ala Leu Leu Tyr Met Ala Leu Tyr Pro Glu Ile Gln Glu Lys 
                325                 330                 335     


Val Gln Ala Glu Ile Asp Arg Val Ile Gly Gln Gly Gln Gln Pro Ser 
            340                 345                 350         


Thr Ala Ala Arg Glu Ser Met Pro Tyr Thr Asn Ala Val Ile His Glu 
        355                 360                 365             


Val Gln Arg Met Gly Asn Ile Ile Pro Leu Asn Val Pro Arg Glu Val 
    370                 375                 380                 


Thr Val Asp Thr Thr Leu Ala Gly Tyr His Leu Pro Lys Gly Thr Met 
385                 390                 395                 400 


Ile Leu Thr Asn Leu Thr Ala Leu His Arg Asp Pro Thr Glu Trp Ala 
                405                 410                 415     


Thr Pro Asp Thr Phe Asn Pro Asp His Phe Leu Glu Asn Gly Gln Phe 
            420                 425                 430         


Lys Lys Arg Glu Ala Phe Met Pro Phe Ser Ile Gly Lys Arg Ala Cys 
        435                 440                 445             


Leu Gly Glu Gln Leu Ala Arg Thr Glu Leu Phe Ile Phe Phe Thr Ser 
    450                 455                 460                 


Leu Met Gln Lys Phe Thr Phe Arg Pro Pro Asn Asn Glu Lys Leu Ser 
465                 470                 475                 480 


Leu Lys Phe Arg Met Gly Ile Thr Ile Ser Pro Val Ser His Arg Leu 
                485                 490                 495     


Cys Ala Val Pro Gln Val 
            500         


<210>  244
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  244

Met Asp Leu Ile Pro Asn Leu Ala Val Glu Thr Trp Leu Leu Leu Ala 
1               5                   10                  15      


Val Ser Leu Val Leu Leu Tyr Leu Tyr Gly Thr Arg Thr His Gly Leu 
            20                  25                  30          


Phe Lys Arg Leu Gly Ile Pro Gly Pro Thr Pro Leu Pro Leu Leu Gly 
        35                  40                  45              


Asn Val Leu Ser Tyr Arg Gln Gly Leu Trp Lys Phe Asp Thr Glu Cys 
    50                  55                  60                  


Tyr Lys Lys Tyr Gly Lys Met Trp Gly Thr Tyr Glu Gly Gln Leu Pro 
65                  70                  75                  80  


Val Leu Ala Ile Thr Asp Pro Asp Val Ile Arg Thr Val Leu Val Lys 
                85                  90                  95      


Glu Cys Tyr Ser Val Phe Thr Asn Arg Arg Ser Leu Gly Pro Val Gly 
            100                 105                 110         


Phe Met Lys Ser Ala Ile Ser Leu Ala Glu Asp Glu Glu Trp Lys Arg 
        115                 120                 125             


Ile Arg Ser Leu Leu Ser Pro Thr Phe Thr Ser Gly Lys Leu Lys Glu 
    130                 135                 140                 


Met Phe Pro Ile Ile Ala Gln Tyr Gly Asp Val Leu Val Arg Asn Leu 
145                 150                 155                 160 


Arg Arg Glu Ala Glu Lys Gly Lys Pro Val Thr Leu Lys Asp Ile Phe 
                165                 170                 175     


Gly Ala Tyr Ser Met Asp Val Ile Thr Gly Thr Ser Phe Gly Val Asn 
            180                 185                 190         


Ile Asp Ser Leu Asn Asn Pro Gln Asp Pro Phe Val Glu Ser Thr Lys 
        195                 200                 205             


Lys Phe Leu Lys Phe Gly Phe Leu Asp Pro Leu Phe Leu Ser Ile Ile 
    210                 215                 220                 


Leu Phe Pro Phe Leu Thr Pro Val Phe Glu Ala Leu Asn Val Ser Leu 
225                 230                 235                 240 


Phe Pro Lys Asp Thr Ile Asn Phe Leu Ser Lys Ser Val Asn Arg Met 
                245                 250                 255     


Lys Lys Ser Arg Leu Asn Asp Lys Gln Lys His Arg Leu Asp Phe Leu 
            260                 265                 270         


Gln Leu Met Ile Asp Ser Gln Asn Ser Lys Glu Thr Glu Ser His Lys 
        275                 280                 285             


Ala Leu Ser Asp Leu Glu Leu Ala Ala Gln Ser Ile Ile Phe Ile Phe 
    290                 295                 300                 


Ala Gly Tyr Glu Thr Thr Ser Ser Val Leu Ser Phe Thr Leu Tyr Glu 
305                 310                 315                 320 


Leu Ala Thr His Pro Asp Val Gln Gln Lys Leu Gln Lys Glu Ile Asp 
                325                 330                 335     


Ala Val Leu Pro Asn Lys Ala Pro Pro Thr Tyr Asp Ala Val Val Gln 
            340                 345                 350         


Met Glu Tyr Leu Asp Met Val Val Asn Glu Thr Leu Arg Leu Phe Pro 
        355                 360                 365             


Val Ala Ile Arg Leu Glu Arg Thr Cys Lys Lys Asp Val Glu Ile Asn 
    370                 375                 380                 


Gly Val Phe Ile Pro Lys Gly Ser Met Val Val Ile Pro Thr Tyr Ala 
385                 390                 395                 400 


Leu His His Asp Pro Lys Tyr Trp Thr Glu Pro Glu Glu Phe Arg Pro 
                405                 410                 415     


Glu Arg Phe Ser Lys Lys Lys Asp Ser Ile Asp Pro Tyr Ile Tyr Thr 
            420                 425                 430         


Pro Phe Gly Thr Gly Pro Arg Asn Cys Ile Gly Met Arg Phe Ala Leu 
        435                 440                 445             


Met Asn Met Lys Leu Ala Leu Ile Arg Val Leu Gln Asn Phe Ser Phe 
    450                 455                 460                 


Lys Pro Cys Lys Glu Thr Gln Ile Pro Leu Lys Leu Asp Thr Gln Gly 
465                 470                 475                 480 


Leu Leu Gln Pro Glu Lys Pro Ile Val Leu Lys Val Asp Ser Arg Asp 
                485                 490                 495     


Gly Thr Leu Ser Gly Glu 
            500         


<210>  245
<211>  519
<212>  PRT
<213>  Homo sapiens

<400>  245

Met Ser Val Ser Val Leu Ser Pro Ser Arg Leu Leu Gly Asp Val Ser 
1               5                   10                  15      


Gly Ile Leu Gln Ala Ala Ser Leu Leu Ile Leu Leu Leu Leu Leu Ile 
            20                  25                  30          


Lys Ala Val Gln Leu Tyr Leu His Arg Gln Trp Leu Leu Lys Ala Leu 
        35                  40                  45              


Gln Gln Phe Pro Cys Pro Pro Ser His Trp Leu Phe Gly His Ile Gln 
    50                  55                  60                  


Glu Leu Gln Gln Asp Gln Glu Leu Gln Arg Ile Gln Lys Trp Val Glu 
65                  70                  75                  80  


Thr Phe Pro Ser Ala Cys Pro His Trp Leu Trp Gly Gly Lys Val Arg 
                85                  90                  95      


Val Gln Leu Tyr Asp Pro Asp Tyr Met Lys Val Ile Leu Gly Arg Ser 
            100                 105                 110         


Asp Pro Lys Ser His Gly Ser Tyr Arg Phe Leu Ala Pro Trp Ile Gly 
        115                 120                 125             


Tyr Gly Leu Leu Leu Leu Asn Gly Gln Thr Trp Phe Gln His Arg Arg 
    130                 135                 140                 


Met Leu Thr Pro Ala Phe His Tyr Asp Ile Leu Lys Pro Tyr Val Gly 
145                 150                 155                 160 


Leu Met Ala Asp Ser Val Arg Val Met Leu Asp Lys Trp Glu Glu Leu 
                165                 170                 175     


Leu Gly Gln Asp Ser Pro Leu Glu Val Phe Gln His Val Ser Leu Met 
            180                 185                 190         


Thr Leu Asp Thr Ile Met Lys Cys Ala Phe Ser His Gln Gly Ser Ile 
        195                 200                 205             


Gln Val Asp Arg Asn Ser Gln Ser Tyr Ile Gln Ala Ile Ser Asp Leu 
    210                 215                 220                 


Asn Asn Leu Val Phe Ser Arg Val Arg Asn Ala Phe His Gln Asn Asp 
225                 230                 235                 240 


Thr Ile Tyr Ser Leu Thr Ser Ala Gly Arg Trp Thr His Arg Ala Cys 
                245                 250                 255     


Gln Leu Ala His Gln His Thr Asp Gln Val Ile Gln Leu Arg Lys Ala 
            260                 265                 270         


Gln Leu Gln Lys Glu Gly Glu Leu Glu Lys Ile Lys Arg Lys Arg His 
        275                 280                 285             


Leu Asp Phe Leu Asp Ile Leu Leu Leu Ala Lys Met Glu Asn Gly Ser 
    290                 295                 300                 


Ile Leu Ser Asp Lys Asp Leu Arg Ala Glu Val Asp Thr Phe Met Phe 
305                 310                 315                 320 


Glu Gly His Asp Thr Thr Ala Ser Gly Ile Ser Trp Ile Leu Tyr Ala 
                325                 330                 335     


Leu Ala Thr His Pro Lys His Gln Glu Arg Cys Arg Glu Glu Ile His 
            340                 345                 350         


Ser Leu Leu Gly Asp Gly Ala Ser Ile Thr Trp Asn His Leu Asp Gln 
        355                 360                 365             


Met Pro Tyr Thr Thr Met Cys Ile Lys Glu Ala Leu Arg Leu Tyr Pro 
    370                 375                 380                 


Pro Val Pro Gly Ile Gly Arg Glu Leu Ser Thr Pro Val Thr Phe Pro 
385                 390                 395                 400 


Asp Gly Arg Ser Leu Pro Lys Gly Ile Met Val Leu Leu Ser Ile Tyr 
                405                 410                 415     


Gly Leu His His Asn Pro Lys Val Trp Pro Asn Pro Glu Val Phe Asp 
            420                 425                 430         


Pro Phe Arg Phe Ala Pro Gly Ser Ala Gln His Ser His Ala Phe Leu 
        435                 440                 445             


Pro Phe Ser Gly Gly Ser Arg Asn Cys Ile Gly Lys Gln Phe Ala Met 
    450                 455                 460                 


Asn Glu Leu Lys Val Ala Thr Ala Leu Thr Leu Leu Arg Phe Glu Leu 
465                 470                 475                 480 


Leu Pro Asp Pro Thr Arg Ile Pro Ile Pro Ile Ala Arg Leu Val Leu 
                485                 490                 495     


Lys Ser Lys Asn Gly Ile His Leu Arg Leu Arg Arg Leu Pro Asn Pro 
            500                 505                 510         


Cys Glu Asp Lys Asp Gln Leu 
        515                 


<210>  246
<211>  511
<212>  PRT
<213>  Homo sapiens

<400>  246

Met Val Pro Ser Phe Leu Ser Leu Ser Phe Ser Ser Leu Gly Leu Trp 
1               5                   10                  15      


Ala Ser Gly Leu Ile Leu Val Leu Gly Phe Leu Lys Leu Ile His Leu 
            20                  25                  30          


Leu Leu Arg Arg Gln Thr Leu Ala Lys Ala Met Asp Lys Phe Pro Gly 
        35                  40                  45              


Pro Pro Thr His Trp Leu Phe Gly His Ala Leu Glu Ile Gln Glu Thr 
    50                  55                  60                  


Gly Ser Leu Asp Lys Val Val Ser Trp Ala His Gln Phe Pro Tyr Ala 
65                  70                  75                  80  


His Pro Leu Trp Phe Gly Gln Phe Ile Gly Phe Leu Asn Ile Tyr Glu 
                85                  90                  95      


Pro Asp Tyr Ala Lys Ala Val Tyr Ser Arg Gly Asp Pro Lys Ala Pro 
            100                 105                 110         


Asp Val Tyr Asp Phe Phe Leu Gln Trp Ile Gly Arg Gly Leu Leu Val 
        115                 120                 125             


Leu Glu Gly Pro Lys Trp Leu Gln His Arg Lys Leu Leu Thr Pro Gly 
    130                 135                 140                 


Phe His Tyr Asp Val Leu Lys Pro Tyr Val Ala Val Phe Thr Glu Ser 
145                 150                 155                 160 


Thr Arg Ile Met Leu Asp Lys Trp Glu Glu Lys Ala Arg Glu Gly Lys 
                165                 170                 175     


Ser Phe Asp Ile Phe Cys Asp Val Gly His Met Ala Leu Asn Thr Leu 
            180                 185                 190         


Met Lys Cys Thr Phe Gly Arg Gly Asp Thr Gly Leu Gly His Arg Asp 
        195                 200                 205             


Ser Ser Tyr Tyr Leu Ala Val Ser Asp Leu Thr Leu Leu Met Gln Gln 
    210                 215                 220                 


Arg Leu Val Ser Phe Gln Tyr His Asn Asp Phe Ile Tyr Trp Leu Thr 
225                 230                 235                 240 


Pro His Gly Arg Arg Phe Leu Arg Ala Cys Gln Val Ala His Asp His 
                245                 250                 255     


Thr Asp Gln Val Ile Arg Glu Arg Lys Ala Ala Leu Gln Asp Glu Lys 
            260                 265                 270         


Val Arg Lys Lys Ile Gln Asn Arg Arg His Leu Asp Phe Leu Asp Ile 
        275                 280                 285             


Leu Leu Gly Ala Arg Asp Glu Asp Asp Ile Lys Leu Ser Asp Ala Asp 
    290                 295                 300                 


Leu Arg Ala Glu Val Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr 
305                 310                 315                 320 


Thr Ser Gly Ile Ser Trp Phe Leu Tyr Cys Met Ala Leu Tyr Pro Glu 
                325                 330                 335     


His Gln His Arg Cys Arg Glu Glu Val Arg Glu Ile Leu Gly Asp Gln 
            340                 345                 350         


Asp Phe Phe Gln Trp Asp Asp Leu Gly Lys Met Thr Tyr Leu Thr Met 
        355                 360                 365             


Cys Ile Lys Glu Ser Phe Arg Leu Tyr Pro Pro Val Pro Gln Val Tyr 
    370                 375                 380                 


Arg Gln Leu Ser Lys Pro Val Thr Phe Val Asp Gly Arg Ser Leu Pro 
385                 390                 395                 400 


Ala Gly Ser Leu Ile Ser Met His Ile Tyr Ala Leu His Arg Asn Ser 
                405                 410                 415     


Ala Val Trp Pro Asp Pro Glu Val Phe Asp Ser Leu Arg Phe Ser Thr 
            420                 425                 430         


Glu Asn Ala Ser Lys Arg His Pro Phe Ala Phe Met Pro Phe Ser Ala 
        435                 440                 445             


Gly Pro Arg Asn Cys Ile Gly Gln Gln Phe Ala Met Ser Glu Met Lys 
    450                 455                 460                 


Val Val Thr Ala Met Cys Leu Leu Arg Phe Glu Phe Ser Leu Asp Pro 
465                 470                 475                 480 


Ser Arg Leu Pro Ile Lys Met Pro Gln Leu Val Leu Arg Ser Lys Asn 
                485                 490                 495     


Gly Phe His Leu His Leu Lys Pro Leu Gly Pro Gly Ser Gly Lys 
            500                 505                 510     


<210>  247
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  247

Met Ala Ala Ala Ala Gly Met Leu Leu Leu Gly Leu Leu Gln Ala Gly 
1               5                   10                  15      


Gly Ser Val Leu Gly Gln Ala Met Glu Lys Val Thr Gly Gly Asn Leu 
            20                  25                  30          


Leu Ser Met Leu Leu Ile Ala Cys Ala Phe Thr Leu Ser Leu Val Tyr 
        35                  40                  45              


Leu Ile Arg Leu Ala Ala Gly His Leu Val Gln Leu Pro Ala Gly Val 
    50                  55                  60                  


Lys Ser Pro Pro Tyr Ile Phe Ser Pro Ile Pro Phe Leu Gly His Ala 
65                  70                  75                  80  


Ile Ala Phe Gly Lys Ser Pro Ile Glu Phe Leu Glu Asn Ala Tyr Glu 
                85                  90                  95      


Lys Tyr Gly Pro Val Phe Ser Phe Thr Met Val Gly Lys Thr Phe Thr 
            100                 105                 110         


Tyr Leu Leu Gly Ser Asp Ala Ala Ala Leu Leu Phe Asn Ser Lys Asn 
        115                 120                 125             


Glu Asp Leu Asn Ala Glu Asp Val Tyr Ser Arg Leu Thr Thr Pro Val 
    130                 135                 140                 


Phe Gly Lys Gly Val Ala Tyr Asp Val Pro Asn Pro Val Phe Leu Glu 
145                 150                 155                 160 


Gln Lys Lys Met Leu Lys Ser Gly Leu Asn Ile Ala His Phe Lys Gln 
                165                 170                 175     


His Val Ser Ile Ile Glu Lys Glu Thr Lys Glu Tyr Phe Glu Ser Trp 
            180                 185                 190         


Gly Glu Ser Gly Glu Lys Asn Val Phe Glu Ala Leu Ser Glu Leu Ile 
        195                 200                 205             


Ile Leu Thr Ala Ser His Cys Leu His Gly Lys Glu Ile Arg Ser Gln 
    210                 215                 220                 


Leu Asn Glu Lys Val Ala Gln Leu Tyr Ala Asp Leu Asp Gly Gly Phe 
225                 230                 235                 240 


Ser His Ala Ala Trp Leu Leu Pro Gly Trp Leu Pro Leu Pro Ser Phe 
                245                 250                 255     


Arg Arg Arg Asp Arg Ala His Arg Glu Ile Lys Asp Ile Phe Tyr Lys 
            260                 265                 270         


Ala Ile Gln Lys Arg Arg Gln Ser Gln Glu Lys Ile Asp Asp Ile Leu 
        275                 280                 285             


Gln Thr Leu Leu Asp Ala Thr Tyr Lys Asp Gly Arg Pro Leu Thr Asp 
    290                 295                 300                 


Asp Glu Val Ala Gly Met Leu Ile Gly Leu Leu Leu Ala Gly Gln His 
305                 310                 315                 320 


Thr Ser Ser Thr Thr Ser Ala Trp Met Gly Phe Phe Leu Ala Arg Asp 
                325                 330                 335     


Lys Thr Leu Gln Lys Lys Cys Tyr Leu Glu Gln Lys Thr Val Cys Gly 
            340                 345                 350         


Glu Asn Leu Pro Pro Leu Thr Tyr Asp Gln Leu Lys Asp Leu Asn Leu 
        355                 360                 365             


Leu Asp Arg Cys Ile Lys Glu Thr Leu Arg Leu Arg Pro Pro Ile Met 
    370                 375                 380                 


Ile Met Met Arg Met Ala Arg Thr Pro Gln Thr Val Ala Gly Tyr Thr 
385                 390                 395                 400 


Ile Pro Pro Gly His Gln Val Cys Val Ser Pro Thr Val Asn Gln Arg 
                405                 410                 415     


Leu Lys Asp Ser Trp Val Glu Arg Leu Asp Phe Asn Pro Asp Arg Tyr 
            420                 425                 430         


Leu Gln Asp Asn Pro Ala Ser Gly Glu Lys Phe Ala Tyr Val Pro Phe 
        435                 440                 445             


Gly Ala Gly Arg His Arg Cys Ile Gly Glu Asn Phe Ala Tyr Val Gln 
    450                 455                 460                 


Ile Lys Thr Ile Trp Ser Thr Met Leu Arg Leu Tyr Glu Phe Asp Leu 
465                 470                 475                 480 


Ile Asp Gly Tyr Phe Pro Thr Val Asn Tyr Thr Thr Met Ile His Thr 
                485                 490                 495     


Pro Glu Asn Pro Val Ile Arg Tyr Lys Arg Arg Ser Lys 
            500                 505                 


<210>  248
<211>  617
<212>  PRT
<213>  Homo sapiens

<400>  248

Met Pro Ala Leu Ser Arg Trp Ala Ser Leu Pro Gly Pro Ser Met Arg 
1               5                   10                  15      


Glu Ala Ala Phe Met Tyr Ser Thr Ala Val Ala Ile Phe Leu Val Ile 
            20                  25                  30          


Leu Val Ala Ala Leu Gln Gly Ser Ala Pro Arg Glu Ser Pro Leu Pro 
        35                  40                  45              


Tyr His Ile Pro Leu Asp Pro Glu Gly Ser Leu Glu Leu Ser Trp Asn 
    50                  55                  60                  


Val Ser Tyr Thr Gln Glu Ala Ile His Phe Gln Leu Leu Val Arg Arg 
65                  70                  75                  80  


Leu Lys Ala Gly Val Leu Phe Gly Met Ser Asp Arg Gly Glu Leu Glu 
                85                  90                  95      


Asn Ala Asp Leu Val Val Leu Trp Thr Asp Gly Asp Thr Ala Tyr Phe 
            100                 105                 110         


Ala Asp Ala Trp Ser Asp Gln Lys Gly Gln Ile His Leu Asp Pro Gln 
        115                 120                 125             


Gln Asp Tyr Gln Leu Leu Gln Val Gln Arg Thr Pro Glu Gly Leu Thr 
    130                 135                 140                 


Leu Leu Phe Lys Arg Pro Phe Gly Thr Cys Asp Pro Lys Asp Tyr Leu 
145                 150                 155                 160 


Ile Glu Asp Gly Thr Val His Leu Val Tyr Gly Ile Leu Glu Glu Pro 
                165                 170                 175     


Phe Arg Ser Leu Glu Ala Ile Asn Gly Ser Gly Leu Gln Met Gly Leu 
            180                 185                 190         


Gln Arg Val Gln Leu Leu Lys Pro Asn Ile Pro Glu Pro Glu Leu Pro 
        195                 200                 205             


Ser Asp Ala Cys Thr Met Glu Val Gln Ala Pro Asn Ile Gln Ile Pro 
    210                 215                 220                 


Ser Gln Glu Thr Thr Tyr Trp Cys Tyr Ile Lys Glu Leu Pro Lys Gly 
225                 230                 235                 240 


Phe Ser Arg His His Ile Ile Lys Tyr Glu Pro Ile Val Thr Lys Gly 
                245                 250                 255     


Asn Glu Ala Leu Val His His Met Glu Val Phe Gln Cys Ala Pro Glu 
            260                 265                 270         


Met Asp Ser Val Pro His Phe Ser Gly Pro Cys Asp Ser Lys Met Lys 
        275                 280                 285             


Pro Asp Arg Leu Asn Tyr Cys Arg His Val Leu Ala Ala Trp Ala Leu 
    290                 295                 300                 


Gly Ala Lys Ala Phe Tyr Tyr Pro Glu Glu Ala Gly Leu Ala Phe Gly 
305                 310                 315                 320 


Gly Pro Gly Ser Ser Arg Tyr Leu Arg Leu Glu Val His Tyr His Asn 
                325                 330                 335     


Pro Leu Val Ile Glu Gly Arg Asn Asp Ser Ser Gly Ile Arg Leu Tyr 
            340                 345                 350         


Tyr Thr Ala Lys Leu Arg Arg Phe Asn Ala Gly Ile Met Glu Leu Gly 
        355                 360                 365             


Leu Val Tyr Thr Pro Val Met Ala Ile Pro Pro Arg Glu Thr Ala Phe 
    370                 375                 380                 


Ile Leu Thr Gly Tyr Cys Thr Asp Lys Cys Thr Gln Leu Ala Leu Pro 
385                 390                 395                 400 


Pro Ser Gly Ile His Ile Phe Ala Ser Gln Leu His Thr His Leu Thr 
                405                 410                 415     


Gly Arg Lys Val Val Thr Val Leu Val Arg Asp Gly Arg Glu Trp Glu 
            420                 425                 430         


Ile Val Asn Gln Asp Asn His Tyr Ser Pro His Phe Gln Glu Ile Arg 
        435                 440                 445             


Met Leu Lys Lys Val Val Ser Val His Pro Gly Asp Val Leu Ile Thr 
    450                 455                 460                 


Ser Cys Thr Tyr Asn Thr Glu Asp Arg Glu Leu Ala Thr Val Gly Gly 
465                 470                 475                 480 


Phe Gly Ile Leu Glu Glu Met Cys Val Asn Tyr Val His Tyr Tyr Pro 
                485                 490                 495     


Gln Thr Gln Leu Glu Leu Cys Lys Ser Ala Val Asp Ala Gly Phe Leu 
            500                 505                 510         


Gln Lys Tyr Phe His Leu Ile Asn Arg Phe Asn Asn Glu Asp Val Cys 
        515                 520                 525             


Thr Cys Pro Gln Ala Ser Val Ser Gln Gln Phe Thr Ser Val Pro Trp 
    530                 535                 540                 


Asn Ser Phe Asn Arg Asp Val Leu Lys Ala Leu Tyr Ser Phe Ala Pro 
545                 550                 555                 560 


Ile Ser Met His Cys Asn Lys Ser Ser Ala Val Arg Phe Gln Gly Glu 
                565                 570                 575     


Trp Asn Leu Gln Pro Leu Pro Lys Val Ile Ser Thr Leu Glu Glu Pro 
            580                 585                 590         


Thr Pro Gln Cys Pro Thr Ser Gln Gly Arg Ser Pro Ala Gly Pro Thr 
        595                 600                 605             


Val Val Ser Ile Gly Gly Gly Lys Gly 
    610                 615         


<210>  249
<211>  1306
<212>  PRT
<213>  Homo sapiens

<400>  249

Met Gly Ala Ala Ser Gly Arg Arg Gly Pro Gly Leu Leu Leu Pro Leu 
1               5                   10                  15      


Pro Leu Leu Leu Leu Leu Pro Pro Gln Pro Ala Leu Ala Leu Asp Pro 
            20                  25                  30          


Gly Leu Gln Pro Gly Asn Phe Ser Ala Asp Glu Ala Gly Ala Gln Leu 
        35                  40                  45              


Phe Ala Gln Ser Tyr Asn Ser Ser Ala Glu Gln Val Leu Phe Gln Ser 
    50                  55                  60                  


Val Ala Ala Ser Trp Ala His Asp Thr Asn Ile Thr Ala Glu Asn Ala 
65                  70                  75                  80  


Arg Arg Gln Glu Glu Ala Ala Leu Leu Ser Gln Glu Phe Ala Glu Ala 
                85                  90                  95      


Trp Gly Gln Lys Ala Lys Glu Leu Tyr Glu Pro Ile Trp Gln Asn Phe 
            100                 105                 110         


Thr Asp Pro Gln Leu Arg Arg Ile Ile Gly Ala Val Arg Thr Leu Gly 
        115                 120                 125             


Ser Ala Asn Leu Pro Leu Ala Lys Arg Gln Gln Tyr Asn Ala Leu Leu 
    130                 135                 140                 


Ser Asn Met Ser Arg Ile Tyr Ser Thr Ala Lys Val Cys Leu Pro Asn 
145                 150                 155                 160 


Lys Thr Ala Thr Cys Trp Ser Leu Asp Pro Asp Leu Thr Asn Ile Leu 
                165                 170                 175     


Ala Ser Ser Arg Ser Tyr Ala Met Leu Leu Phe Ala Trp Glu Gly Trp 
            180                 185                 190         


His Asn Ala Ala Gly Ile Pro Leu Lys Pro Leu Tyr Glu Asp Phe Thr 
        195                 200                 205             


Ala Leu Ser Asn Glu Ala Tyr Lys Gln Asp Gly Phe Thr Asp Thr Gly 
    210                 215                 220                 


Ala Tyr Trp Arg Ser Trp Tyr Asn Ser Pro Thr Phe Glu Asp Asp Leu 
225                 230                 235                 240 


Glu His Leu Tyr Gln Gln Leu Glu Pro Leu Tyr Leu Asn Leu His Ala 
                245                 250                 255     


Phe Val Arg Arg Ala Leu His Arg Arg Tyr Gly Asp Arg Tyr Ile Asn 
            260                 265                 270         


Leu Arg Gly Pro Ile Pro Ala His Leu Leu Gly Asp Met Trp Ala Gln 
        275                 280                 285             


Ser Trp Glu Asn Ile Tyr Asp Met Val Val Pro Phe Pro Asp Lys Pro 
    290                 295                 300                 


Asn Leu Asp Val Thr Ser Thr Met Leu Gln Gln Gly Trp Asn Ala Thr 
305                 310                 315                 320 


His Met Phe Arg Val Ala Glu Glu Phe Phe Thr Ser Leu Glu Leu Ser 
                325                 330                 335     


Pro Met Pro Pro Glu Phe Trp Glu Gly Ser Met Leu Glu Lys Pro Ala 
            340                 345                 350         


Asp Gly Arg Glu Val Val Cys His Ala Ser Ala Trp Asp Phe Tyr Asn 
        355                 360                 365             


Arg Lys Asp Phe Arg Ile Lys Gln Cys Thr Arg Val Thr Met Asp Gln 
    370                 375                 380                 


Leu Ser Thr Val His His Glu Met Gly His Ile Gln Tyr Tyr Leu Gln 
385                 390                 395                 400 


Tyr Lys Asp Leu Pro Val Ser Leu Arg Arg Gly Ala Asn Pro Gly Phe 
                405                 410                 415     


His Glu Ala Ile Gly Asp Val Leu Ala Leu Ser Val Ser Thr Pro Glu 
            420                 425                 430         


His Leu His Lys Ile Gly Leu Leu Asp Arg Val Thr Asn Asp Thr Glu 
        435                 440                 445             


Ser Asp Ile Asn Tyr Leu Leu Lys Met Ala Leu Glu Lys Ile Ala Phe 
    450                 455                 460                 


Leu Pro Phe Gly Tyr Leu Val Asp Gln Trp Arg Trp Gly Val Phe Ser 
465                 470                 475                 480 


Gly Arg Thr Pro Pro Ser Arg Tyr Asn Phe Asp Trp Trp Tyr Leu Arg 
                485                 490                 495     


Thr Lys Tyr Gln Gly Ile Cys Pro Pro Val Thr Arg Asn Glu Thr His 
            500                 505                 510         


Phe Asp Ala Gly Ala Lys Phe His Val Pro Asn Val Thr Pro Tyr Ile 
        515                 520                 525             


Arg Tyr Phe Val Ser Phe Val Leu Gln Phe Gln Phe His Glu Ala Leu 
    530                 535                 540                 


Cys Lys Glu Ala Gly Tyr Glu Gly Pro Leu His Gln Cys Asp Ile Tyr 
545                 550                 555                 560 


Arg Ser Thr Lys Ala Gly Ala Lys Leu Arg Lys Val Leu Gln Ala Gly 
                565                 570                 575     


Ser Ser Arg Pro Trp Gln Glu Val Leu Lys Asp Met Val Gly Leu Asp 
            580                 585                 590         


Ala Leu Asp Ala Gln Pro Leu Leu Lys Tyr Phe Gln Pro Val Thr Gln 
        595                 600                 605             


Trp Leu Gln Glu Gln Asn Gln Gln Asn Gly Glu Val Leu Gly Trp Pro 
    610                 615                 620                 


Glu Tyr Gln Trp His Pro Pro Leu Pro Asp Asn Tyr Pro Glu Gly Ile 
625                 630                 635                 640 


Asp Leu Val Thr Asp Glu Ala Glu Ala Ser Lys Phe Val Glu Glu Tyr 
                645                 650                 655     


Asp Arg Thr Ser Gln Val Val Trp Asn Glu Tyr Ala Glu Ala Asn Trp 
            660                 665                 670         


Asn Tyr Asn Thr Asn Ile Thr Thr Glu Thr Ser Lys Ile Leu Leu Gln 
        675                 680                 685             


Lys Asn Met Gln Ile Ala Asn His Thr Leu Lys Tyr Gly Thr Gln Ala 
    690                 695                 700                 


Arg Lys Phe Asp Val Asn Gln Leu Gln Asn Thr Thr Ile Lys Arg Ile 
705                 710                 715                 720 


Ile Lys Lys Val Gln Asp Leu Glu Arg Ala Ala Leu Pro Ala Gln Glu 
                725                 730                 735     


Leu Glu Glu Tyr Asn Lys Ile Leu Leu Asp Met Glu Thr Thr Tyr Ser 
            740                 745                 750         


Val Ala Thr Val Cys His Pro Asn Gly Ser Cys Leu Gln Leu Glu Pro 
        755                 760                 765             


Asp Leu Thr Asn Val Met Ala Thr Ser Arg Lys Tyr Glu Asp Leu Leu 
    770                 775                 780                 


Trp Ala Trp Glu Gly Trp Arg Asp Lys Ala Gly Arg Ala Ile Leu Gln 
785                 790                 795                 800 


Phe Tyr Pro Lys Tyr Val Glu Leu Ile Asn Gln Ala Ala Arg Leu Asn 
                805                 810                 815     


Gly Tyr Val Asp Ala Gly Asp Ser Trp Arg Ser Met Tyr Glu Thr Pro 
            820                 825                 830         


Ser Leu Glu Gln Asp Leu Glu Arg Leu Phe Gln Glu Leu Gln Pro Leu 
        835                 840                 845             


Tyr Leu Asn Leu His Ala Tyr Val Arg Arg Ala Leu His Arg His Tyr 
    850                 855                 860                 


Gly Ala Gln His Ile Asn Leu Glu Gly Pro Ile Pro Ala His Leu Leu 
865                 870                 875                 880 


Gly Asn Met Trp Ala Gln Thr Trp Ser Asn Ile Tyr Asp Leu Val Val 
                885                 890                 895     


Pro Phe Pro Ser Ala Pro Ser Met Asp Thr Thr Glu Ala Met Leu Lys 
            900                 905                 910         


Gln Gly Trp Thr Pro Arg Arg Met Phe Lys Glu Ala Asp Asp Phe Phe 
        915                 920                 925             


Thr Ser Leu Gly Leu Leu Pro Val Pro Pro Glu Phe Trp Asn Lys Ser 
    930                 935                 940                 


Met Leu Glu Lys Pro Thr Asp Gly Arg Glu Val Val Cys His Ala Ser 
945                 950                 955                 960 


Ala Trp Asp Phe Tyr Asn Gly Lys Asp Phe Arg Ile Lys Gln Cys Thr 
                965                 970                 975     


Thr Val Asn Leu Glu Asp Leu Val Val Ala His His Glu Met Gly His 
            980                 985                 990         


Ile Gln Tyr Phe Met Gln Tyr Lys  Asp Leu Pro Val Ala  Leu Arg Glu 
        995                 1000                 1005             


Gly Ala  Asn Pro Gly Phe His  Glu Ala Ile Gly Asp  Val Leu Ala 
    1010                 1015                 1020             


Leu Ser  Val Ser Thr Pro Lys  His Leu His Ser Leu  Asn Leu Leu 
    1025                 1030                 1035             


Ser Ser  Glu Gly Gly Ser Asp  Glu His Asp Ile Asn  Phe Leu Met 
    1040                 1045                 1050             


Lys Met  Ala Leu Asp Lys Ile  Ala Phe Ile Pro Phe  Ser Tyr Leu 
    1055                 1060                 1065             


Val Asp  Gln Trp Arg Trp Arg  Val Phe Asp Gly Ser  Ile Thr Lys 
    1070                 1075                 1080             


Glu Asn  Tyr Asn Gln Glu Trp  Trp Ser Leu Arg Leu  Lys Tyr Gln 
    1085                 1090                 1095             


Gly Leu  Cys Pro Pro Val Pro  Arg Thr Gln Gly Asp  Phe Asp Pro 
    1100                 1105                 1110             


Gly Ala  Lys Phe His Ile Pro  Ser Ser Val Pro Tyr  Ile Arg Tyr 
    1115                 1120                 1125             


Phe Val  Ser Phe Ile Ile Gln  Phe Gln Phe His Glu  Ala Leu Cys 
    1130                 1135                 1140             


Gln Ala  Ala Gly His Thr Gly  Pro Leu His Lys Cys  Asp Ile Tyr 
    1145                 1150                 1155             


Gln Ser  Lys Glu Ala Gly Gln  Arg Leu Ala Thr Ala  Met Lys Leu 
    1160                 1165                 1170             


Gly Phe  Ser Arg Pro Trp Pro  Glu Ala Met Gln Leu  Ile Thr Gly 
    1175                 1180                 1185             


Gln Pro  Asn Met Ser Ala Ser  Ala Met Leu Ser Tyr  Phe Lys Pro 
    1190                 1195                 1200             


Leu Leu  Asp Trp Leu Arg Thr  Glu Asn Glu Leu His  Gly Glu Lys 
    1205                 1210                 1215             


Leu Gly  Trp Pro Gln Tyr Asn  Trp Thr Pro Asn Ser  Ala Arg Ser 
    1220                 1225                 1230             


Glu Gly  Pro Leu Pro Asp Ser  Gly Arg Val Ser Phe  Leu Gly Leu 
    1235                 1240                 1245             


Asp Leu  Asp Ala Gln Gln Ala  Arg Val Gly Gln Trp  Leu Leu Leu 
    1250                 1255                 1260             


Phe Leu  Gly Ile Ala Leu Leu  Val Ala Thr Leu Gly  Leu Ser Gln 
    1265                 1270                 1275             


Arg Leu  Phe Ser Ile Arg His  Arg Ser Leu His Arg  His Ser His 
    1280                 1285                 1290             


Gly Pro  Gln Phe Gly Ser Glu  Val Glu Leu Arg His  Ser 
    1295                 1300                 1305     


<210>  250
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  250

Met Asn Ala Ser Glu Phe Arg Arg Arg Gly Lys Glu Met Val Asp Tyr 
1               5                   10                  15      


Val Ala Asn Tyr Met Glu Gly Ile Glu Gly Arg Gln Val Tyr Pro Asp 
            20                  25                  30          


Val Glu Pro Gly Tyr Leu Arg Pro Leu Ile Pro Ala Ala Ala Pro Gln 
        35                  40                  45              


Glu Pro Asp Thr Phe Glu Asp Ile Ile Asn Asp Val Glu Lys Ile Ile 
    50                  55                  60                  


Met Pro Gly Val Thr His Trp His Ser Pro Tyr Phe Phe Ala Tyr Phe 
65                  70                  75                  80  


Pro Thr Ala Ser Ser Tyr Pro Ala Met Leu Ala Asp Met Leu Cys Gly 
                85                  90                  95      


Ala Ile Gly Cys Ile Gly Phe Ser Trp Ala Ala Ser Pro Ala Cys Thr 
            100                 105                 110         


Glu Leu Glu Thr Val Met Met Asp Trp Leu Gly Lys Met Leu Glu Leu 
        115                 120                 125             


Pro Lys Ala Phe Leu Asn Glu Lys Ala Gly Glu Gly Gly Gly Val Ile 
    130                 135                 140                 


Gln Gly Ser Ala Ser Glu Ala Thr Leu Val Ala Leu Leu Ala Ala Arg 
145                 150                 155                 160 


Thr Lys Val Ile His Arg Leu Gln Ala Ala Ser Pro Glu Leu Thr Gln 
                165                 170                 175     


Ala Ala Ile Met Glu Lys Leu Val Ala Tyr Ser Ser Asp Gln Ala His 
            180                 185                 190         


Ser Ser Val Glu Arg Ala Gly Leu Ile Gly Gly Val Lys Leu Lys Ala 
        195                 200                 205             


Ile Pro Ser Asp Gly Asn Phe Ala Met Arg Ala Ser Ala Leu Gln Glu 
    210                 215                 220                 


Ala Leu Glu Arg Asp Lys Ala Ala Gly Leu Ile Pro Phe Phe Met Val 
225                 230                 235                 240 


Ala Thr Leu Gly Thr Thr Thr Cys Cys Ser Phe Asp Asn Leu Leu Glu 
                245                 250                 255     


Val Gly Pro Ile Cys Asn Lys Glu Asp Ile Trp Leu His Val Asp Ala 
            260                 265                 270         


Ala Tyr Ala Gly Ser Ala Phe Ile Cys Pro Glu Phe Arg His Leu Leu 
        275                 280                 285             


Asn Gly Val Glu Phe Ala Asp Ser Phe Asn Phe Asn Pro His Lys Trp 
    290                 295                 300                 


Leu Leu Val Asn Phe Asp Cys Ser Ala Met Trp Val Lys Lys Arg Thr 
305                 310                 315                 320 


Asp Leu Thr Gly Ala Phe Arg Leu Asp Pro Thr Tyr Leu Lys His Ser 
                325                 330                 335     


His Gln Asp Ser Gly Leu Ile Thr Asp Tyr Arg His Trp Gln Ile Pro 
            340                 345                 350         


Leu Gly Arg Arg Phe Arg Ser Leu Lys Met Trp Phe Val Phe Arg Met 
        355                 360                 365             


Tyr Gly Val Lys Gly Leu Gln Ala Tyr Ile Arg Lys His Val Gln Leu 
    370                 375                 380                 


Ser His Glu Phe Glu Ser Leu Val Arg Gln Asp Pro Arg Phe Glu Ile 
385                 390                 395                 400 


Cys Val Glu Val Ile Leu Gly Leu Val Cys Phe Arg Leu Lys Gly Ser 
                405                 410                 415     


Asn Lys Val Asn Glu Ala Leu Leu Gln Arg Ile Asn Ser Ala Lys Lys 
            420                 425                 430         


Ile His Leu Val Pro Cys His Leu Arg Asp Lys Phe Val Leu Arg Phe 
        435                 440                 445             


Ala Ile Cys Ser Arg Thr Val Glu Ser Ala His Val Gln Arg Ala Trp 
    450                 455                 460                 


Glu His Ile Lys Glu Leu Ala Ala Asp Val Leu Arg Ala Glu Arg Glu 
465                 470                 475                 480 


<210>  251
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  251

Met Gly Leu Pro Gln Pro Gly Leu Trp Leu Lys Arg Leu Trp Val Leu 
1               5                   10                  15      


Leu Glu Val Ala Val His Val Val Val Gly Lys Val Leu Leu Ile Leu 
            20                  25                  30          


Phe Pro Asp Arg Val Lys Arg Asn Ile Leu Ala Met Gly Glu Lys Thr 
        35                  40                  45              


Gly Met Thr Arg Asn Pro His Phe Ser His Asp Asn Trp Ile Pro Thr 
    50                  55                  60                  


Phe Phe Ser Thr Gln Tyr Phe Trp Phe Val Leu Lys Val Arg Trp Gln 
65                  70                  75                  80  


Arg Leu Glu Asp Thr Thr Glu Leu Gly Gly Leu Ala Pro Asn Cys Pro 
                85                  90                  95      


Val Val Arg Leu Ser Gly Gln Arg Cys Asn Ile Trp Glu Phe Met Gln 
            100                 105                 110         


Gly Asn Arg Pro Leu Val Leu Asn Phe Gly Ser Cys Thr Pro Ser Phe 
        115                 120                 125             


Met Phe Lys Phe Asp Gln Phe Lys Arg Leu Ile Glu Asp Phe Ser Ser 
    130                 135                 140                 


Ile Ala Asp Phe Leu Val Ile Tyr Ile Glu Glu Ala His Ala Ser Asp 
145                 150                 155                 160 


Gly Trp Ala Phe Lys Asn Asn Met Asp Ile Arg Asn His Gln Asn Leu 
                165                 170                 175     


Gln Asp Arg Leu Gln Ala Ala His Leu Leu Leu Ala Arg Ser Pro Gln 
            180                 185                 190         


Cys Pro Val Val Val Asp Thr Met Gln Asn Gln Ser Ser Gln Leu Tyr 
        195                 200                 205             


Ala Ala Leu Pro Glu Arg Leu Tyr Ile Ile Gln Glu Gly Arg Ile Leu 
    210                 215                 220                 


Tyr Lys Gly Lys Ser Gly Pro Trp Asn Tyr Asn Pro Glu Glu Val Arg 
225                 230                 235                 240 


Ala Val Leu Glu Lys Leu His Ser 
                245             


<210>  252
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  252

Met Gly Ile Leu Ser Val Asp Leu Leu Ile Thr Leu Gln Ile Leu Pro 
1               5                   10                  15      


Val Phe Phe Ser Asn Cys Leu Phe Leu Ala Leu Tyr Asp Ser Val Ile 
            20                  25                  30          


Leu Leu Lys His Val Val Leu Leu Leu Ser Arg Ser Lys Ser Thr Arg 
        35                  40                  45              


Gly Glu Trp Arg Arg Met Leu Thr Ser Glu Gly Leu Arg Cys Val Trp 
    50                  55                  60                  


Lys Ser Phe Leu Leu Asp Ala Tyr Lys Gln Val Lys Leu Gly Glu Asp 
65                  70                  75                  80  


Ala Pro Asn Ser Ser Val Val His Val Ser Ser Thr Glu Gly Gly Asp 
                85                  90                  95      


Asn Ser Gly Asn Gly Thr Gln Glu Lys Ile Ala Glu Gly Ala Thr Cys 
            100                 105                 110         


His Leu Leu Asp Phe Ala Ser Pro Glu Arg Pro Leu Val Val Asn Phe 
        115                 120                 125             


Gly Ser Ala Thr Pro Pro Phe Thr Ser Gln Leu Pro Ala Phe Arg Lys 
    130                 135                 140                 


Leu Val Glu Glu Phe Ser Ser Val Ala Asp Phe Leu Leu Val Tyr Ile 
145                 150                 155                 160 


Asp Glu Ala His Pro Ser Asp Gly Trp Ala Ile Pro Gly Asp Ser Ser 
                165                 170                 175     


Leu Ser Phe Glu Val Lys Lys His Gln Asn Gln Glu Asp Arg Cys Ala 
            180                 185                 190         


Ala Ala Gln Gln Leu Leu Glu Arg Phe Ser Leu Pro Pro Gln Cys Arg 
        195                 200                 205             


Val Val Ala Asp Arg Met Asp Asn Asn Ala Asn Ile Ala Tyr Gly Val 
    210                 215                 220                 


Ala Phe Glu Arg Val Cys Ile Val Gln Arg Gln Lys Ile Ala Tyr Leu 
225                 230                 235                 240 


Gly Gly Lys Gly Pro Phe Ser Tyr Asn Leu Gln Glu Val Arg His Trp 
                245                 250                 255     


Leu Glu Lys Asn Phe Ser Lys Arg Lys Lys Thr Arg Leu Ala Gly 
            260                 265                 270     


<210>  253
<211>  446
<212>  PRT
<213>  Homo sapiens

<400>  253

Met Arg Thr Leu Asn Thr Ser Ala Met Asp Gly Thr Gly Leu Val Val 
1               5                   10                  15      


Glu Arg Asp Phe Ser Val Arg Ile Leu Thr Ala Cys Phe Leu Ser Leu 
            20                  25                  30          


Leu Ile Leu Ser Thr Leu Leu Gly Asn Thr Leu Val Cys Ala Ala Val 
        35                  40                  45              


Ile Arg Phe Arg His Leu Arg Ser Lys Val Thr Asn Phe Phe Val Ile 
    50                  55                  60                  


Ser Leu Ala Val Ser Asp Leu Leu Val Ala Val Leu Val Met Pro Trp 
65                  70                  75                  80  


Lys Ala Val Ala Glu Ile Ala Gly Phe Trp Pro Phe Gly Ser Phe Cys 
                85                  90                  95      


Asn Ile Trp Val Ala Phe Asp Ile Met Cys Ser Thr Ala Ser Ile Leu 
            100                 105                 110         


Asn Leu Cys Val Ile Ser Val Asp Arg Tyr Trp Ala Ile Ser Ser Pro 
        115                 120                 125             


Phe Arg Tyr Glu Arg Lys Met Thr Pro Lys Ala Ala Phe Ile Leu Ile 
    130                 135                 140                 


Ser Val Ala Trp Thr Leu Ser Val Leu Ile Ser Phe Ile Pro Val Gln 
145                 150                 155                 160 


Leu Ser Trp His Lys Ala Lys Pro Thr Ser Pro Ser Asp Gly Asn Ala 
                165                 170                 175     


Thr Ser Leu Ala Glu Thr Ile Asp Asn Cys Asp Ser Ser Leu Ser Arg 
            180                 185                 190         


Thr Tyr Ala Ile Ser Ser Ser Val Ile Ser Phe Tyr Ile Pro Val Ala 
        195                 200                 205             


Ile Met Ile Val Thr Tyr Thr Arg Ile Tyr Arg Ile Ala Gln Lys Gln 
    210                 215                 220                 


Ile Arg Arg Ile Ala Ala Leu Glu Arg Ala Ala Val His Ala Lys Asn 
225                 230                 235                 240 


Cys Gln Thr Thr Thr Gly Asn Gly Lys Pro Val Glu Cys Ser Gln Pro 
                245                 250                 255     


Glu Ser Ser Phe Lys Met Ser Phe Lys Arg Glu Thr Lys Val Leu Lys 
            260                 265                 270         


Thr Leu Ser Val Ile Met Gly Val Phe Val Cys Cys Trp Leu Pro Phe 
        275                 280                 285             


Phe Ile Leu Asn Cys Ile Leu Pro Phe Cys Gly Ser Gly Glu Thr Gln 
    290                 295                 300                 


Pro Phe Cys Ile Asp Ser Asn Thr Phe Asp Val Phe Val Trp Phe Gly 
305                 310                 315                 320 


Trp Ala Asn Ser Ser Leu Asn Pro Ile Ile Tyr Ala Phe Asn Ala Asp 
                325                 330                 335     


Phe Arg Lys Ala Phe Ser Thr Leu Leu Gly Cys Tyr Arg Leu Cys Pro 
            340                 345                 350         


Ala Thr Asn Asn Ala Ile Glu Thr Val Ser Ile Asn Asn Asn Gly Ala 
        355                 360                 365             


Ala Met Phe Ser Ser His His Glu Pro Arg Gly Ser Ile Ser Lys Glu 
    370                 375                 380                 


Cys Asn Leu Val Tyr Leu Ile Pro His Ala Val Gly Ser Ser Glu Asp 
385                 390                 395                 400 


Leu Lys Lys Glu Glu Ala Ala Gly Ile Ala Arg Pro Leu Glu Lys Leu 
                405                 410                 415     


Ser Pro Ala Leu Ser Val Ile Leu Asp Tyr Asp Thr Asp Val Ser Leu 
            420                 425                 430         


Glu Lys Ile Gln Pro Ile Thr Gln Asn Gly Gln His Pro Thr 
        435                 440                 445     


<210>  254
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  254

Met Asp Pro Leu Asn Leu Ser Trp Tyr Asp Asp Asp Leu Glu Arg Gln 
1               5                   10                  15      


Asn Trp Ser Arg Pro Phe Asn Gly Ser Asp Gly Lys Ala Asp Arg Pro 
            20                  25                  30          


His Tyr Asn Tyr Tyr Ala Thr Leu Leu Thr Leu Leu Ile Ala Val Ile 
        35                  40                  45              


Val Phe Gly Asn Val Leu Val Cys Met Ala Val Ser Arg Glu Lys Ala 
    50                  55                  60                  


Leu Gln Thr Thr Thr Asn Tyr Leu Ile Val Ser Leu Ala Val Ala Asp 
65                  70                  75                  80  


Leu Leu Val Ala Thr Leu Val Met Pro Trp Val Val Tyr Leu Glu Val 
                85                  90                  95      


Val Gly Glu Trp Lys Phe Ser Arg Ile His Cys Asp Ile Phe Val Thr 
            100                 105                 110         


Leu Asp Val Met Met Cys Thr Ala Ser Ile Leu Asn Leu Cys Ala Ile 
        115                 120                 125             


Ser Ile Asp Arg Tyr Thr Ala Val Ala Met Pro Met Leu Tyr Asn Thr 
    130                 135                 140                 


Arg Tyr Ser Ser Lys Arg Arg Val Thr Val Met Ile Ser Ile Val Trp 
145                 150                 155                 160 


Val Leu Ser Phe Thr Ile Ser Cys Pro Leu Leu Phe Gly Leu Asn Asn 
                165                 170                 175     


Ala Asp Gln Asn Glu Cys Ile Ile Ala Asn Pro Ala Phe Val Val Tyr 
            180                 185                 190         


Ser Ser Ile Val Ser Phe Tyr Val Pro Phe Ile Val Thr Leu Leu Val 
        195                 200                 205             


Tyr Ile Lys Ile Tyr Ile Val Leu Arg Arg Arg Arg Lys Arg Val Asn 
    210                 215                 220                 


Thr Lys Arg Ser Ser Arg Ala Phe Arg Ala His Leu Arg Ala Pro Leu 
225                 230                 235                 240 


Lys Gly Asn Cys Thr His Pro Glu Asp Met Lys Leu Cys Thr Val Ile 
                245                 250                 255     


Met Lys Ser Asn Gly Ser Phe Pro Val Asn Arg Arg Arg Val Glu Ala 
            260                 265                 270         


Ala Arg Arg Ala Gln Glu Leu Glu Met Glu Met Leu Ser Ser Thr Ser 
        275                 280                 285             


Pro Pro Glu Arg Thr Arg Tyr Ser Pro Ile Pro Pro Ser His His Gln 
    290                 295                 300                 


Leu Thr Leu Pro Asp Pro Ser His His Gly Leu His Ser Thr Pro Asp 
305                 310                 315                 320 


Ser Pro Ala Lys Pro Glu Lys Asn Gly His Ala Lys Asp His Pro Lys 
                325                 330                 335     


Ile Ala Lys Ile Phe Glu Ile Gln Thr Met Pro Asn Gly Lys Thr Arg 
            340                 345                 350         


Thr Ser Leu Lys Thr Met Ser Arg Arg Lys Leu Ser Gln Gln Lys Glu 
        355                 360                 365             


Lys Lys Ala Thr Gln Met Leu Ala Ile Val Leu Gly Val Phe Ile Ile 
    370                 375                 380                 


Cys Trp Leu Pro Phe Phe Ile Thr His Ile Leu Asn Ile His Cys Asp 
385                 390                 395                 400 


Cys Asn Ile Pro Pro Val Leu Tyr Ser Ala Phe Thr Trp Leu Gly Tyr 
                405                 410                 415     


Val Asn Ser Ala Val Asn Pro Ile Ile Tyr Thr Thr Phe Asn Ile Glu 
            420                 425                 430         


Phe Arg Lys Ala Phe Leu Lys Ile Leu His Cys 
        435                 440             


<210>  255
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  255

Met Ala Ser Leu Ser Gln Leu Ser Gly His Leu Asn Tyr Thr Cys Gly 
1               5                   10                  15      


Ala Glu Asn Ser Thr Gly Ala Ser Gln Ala Arg Pro His Ala Tyr Tyr 
            20                  25                  30          


Ala Leu Ser Tyr Cys Ala Leu Ile Leu Ala Ile Val Phe Gly Asn Gly 
        35                  40                  45              


Leu Val Cys Met Ala Val Leu Lys Glu Arg Ala Leu Gln Thr Thr Thr 
    50                  55                  60                  


Asn Tyr Leu Val Val Ser Leu Ala Val Ala Asp Leu Leu Val Ala Thr 
65                  70                  75                  80  


Leu Val Met Pro Trp Val Val Tyr Leu Glu Val Thr Gly Gly Val Trp 
                85                  90                  95      


Asn Phe Ser Arg Ile Cys Cys Asp Val Phe Val Thr Leu Asp Val Met 
            100                 105                 110         


Met Cys Thr Ala Ser Ile Leu Asn Leu Cys Ala Ile Ser Ile Asp Arg 
        115                 120                 125             


Tyr Thr Ala Val Val Met Pro Val His Tyr Gln His Gly Thr Gly Gln 
    130                 135                 140                 


Ser Ser Cys Arg Arg Val Ala Leu Met Ile Thr Ala Val Trp Val Leu 
145                 150                 155                 160 


Ala Phe Ala Val Ser Cys Pro Leu Leu Phe Gly Phe Asn Thr Thr Gly 
                165                 170                 175     


Asp Pro Thr Val Cys Ser Ile Ser Asn Pro Asp Phe Val Ile Tyr Ser 
            180                 185                 190         


Ser Val Val Ser Phe Tyr Leu Pro Phe Gly Val Thr Val Leu Val Tyr 
        195                 200                 205             


Ala Arg Ile Tyr Val Val Leu Lys Gln Arg Arg Arg Lys Arg Ile Leu 
    210                 215                 220                 


Thr Arg Gln Asn Ser Gln Cys Asn Ser Val Arg Pro Gly Phe Pro Gln 
225                 230                 235                 240 


Gln Thr Leu Ser Pro Asp Pro Ala His Leu Glu Leu Lys Arg Tyr Tyr 
                245                 250                 255     


Ser Ile Cys Gln Asp Thr Ala Leu Gly Gly Pro Gly Phe Gln Glu Arg 
            260                 265                 270         


Gly Gly Glu Leu Lys Arg Glu Glu Lys Thr Arg Asn Ser Leu Ser Pro 
        275                 280                 285             


Thr Ile Ala Pro Lys Leu Ser Leu Glu Val Arg Lys Leu Ser Asn Gly 
    290                 295                 300                 


Arg Leu Ser Thr Ser Leu Lys Leu Gly Pro Leu Gln Pro Arg Gly Val 
305                 310                 315                 320 


Pro Leu Arg Glu Lys Lys Ala Thr Gln Met Val Ala Ile Val Leu Gly 
                325                 330                 335     


Ala Phe Ile Val Cys Trp Leu Pro Phe Phe Leu Thr His Val Leu Asn 
            340                 345                 350         


Thr His Cys Gln Thr Cys His Val Ser Pro Glu Leu Tyr Ser Ala Thr 
        355                 360                 365             


Thr Trp Leu Gly Tyr Val Asn Ser Ala Leu Asn Pro Val Ile Tyr Thr 
    370                 375                 380                 


Thr Phe Asn Ile Glu Phe Arg Lys Ala Phe Leu Lys Ile Leu Ser Cys 
385                 390                 395                 400 


<210>  256
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  256

Met Gly Asn Arg Ser Thr Ala Asp Ala Asp Gly Leu Leu Ala Gly Arg 
1               5                   10                  15      


Gly Pro Ala Ala Gly Ala Ser Ala Gly Ala Ser Ala Gly Leu Ala Gly 
            20                  25                  30          


Gln Gly Ala Ala Ala Leu Val Gly Gly Val Leu Leu Ile Gly Ala Val 
        35                  40                  45              


Leu Ala Gly Asn Ser Leu Val Cys Val Ser Val Ala Thr Glu Arg Ala 
    50                  55                  60                  


Leu Gln Thr Pro Thr Asn Ser Phe Ile Val Ser Leu Ala Ala Ala Asp 
65                  70                  75                  80  


Leu Leu Leu Ala Leu Leu Val Leu Pro Leu Phe Val Tyr Ser Glu Val 
                85                  90                  95      


Gln Gly Gly Ala Trp Leu Leu Ser Pro Arg Leu Cys Asp Ala Leu Met 
            100                 105                 110         


Ala Met Asp Val Met Leu Cys Thr Ala Ser Ile Phe Asn Leu Cys Ala 
        115                 120                 125             


Ile Ser Val Asp Arg Phe Val Ala Val Ala Val Pro Leu Arg Tyr Asn 
    130                 135                 140                 


Arg Gln Gly Gly Ser Arg Arg Gln Leu Leu Leu Ile Gly Ala Thr Trp 
145                 150                 155                 160 


Leu Leu Ser Ala Ala Val Ala Ala Pro Val Leu Cys Gly Leu Asn Asp 
                165                 170                 175     


Val Arg Gly Arg Asp Pro Ala Val Cys Arg Leu Glu Asp Arg Asp Tyr 
            180                 185                 190         


Val Val Tyr Ser Ser Val Cys Ser Phe Phe Leu Pro Cys Pro Leu Met 
        195                 200                 205             


Leu Leu Leu Tyr Trp Ala Thr Phe Arg Gly Leu Gln Arg Trp Glu Val 
    210                 215                 220                 


Ala Arg Arg Ala Lys Leu His Gly Arg Ala Pro Arg Arg Pro Ser Gly 
225                 230                 235                 240 


Pro Gly Pro Pro Ser Pro Thr Pro Pro Ala Pro Arg Leu Pro Gln Asp 
                245                 250                 255     


Pro Cys Gly Pro Asp Cys Ala Pro Pro Ala Pro Gly Leu Pro Arg Gly 
            260                 265                 270         


Pro Cys Gly Pro Asp Cys Ala Pro Ala Ala Pro Ser Leu Pro Gln Asp 
        275                 280                 285             


Pro Cys Gly Pro Asp Cys Ala Pro Pro Ala Pro Gly Leu Pro Pro Asp 
    290                 295                 300                 


Pro Cys Gly Ser Asn Cys Ala Pro Pro Asp Ala Val Arg Ala Ala Ala 
305                 310                 315                 320 


Leu Pro Pro Gln Thr Pro Pro Gln Thr Arg Arg Arg Arg Arg Ala Lys 
                325                 330                 335     


Ile Thr Gly Arg Glu Arg Lys Ala Met Arg Val Leu Pro Val Val Val 
            340                 345                 350         


Gly Ala Phe Leu Leu Cys Trp Thr Pro Phe Phe Val Val His Ile Thr 
        355                 360                 365             


Gln Ala Leu Cys Pro Ala Cys Ser Val Pro Pro Arg Leu Val Ser Ala 
    370                 375                 380                 


Val Thr Trp Leu Gly Tyr Val Asn Ser Ala Leu Asn Pro Val Ile Tyr 
385                 390                 395                 400 


Thr Val Phe Asn Ala Glu Phe Arg Asn Val Phe Arg Lys Ala Leu Arg 
                405                 410                 415     


Ala Cys Cys 
            


<210>  257
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  257

Met Leu Pro Pro Gly Ser Asn Gly Thr Ala Tyr Pro Gly Gln Phe Ala 
1               5                   10                  15      


Leu Tyr Gln Gln Leu Ala Gln Gly Asn Ala Val Gly Gly Ser Ala Gly 
            20                  25                  30          


Ala Pro Pro Leu Gly Pro Ser Gln Val Val Thr Ala Cys Leu Leu Thr 
        35                  40                  45              


Leu Leu Ile Ile Trp Thr Leu Leu Gly Asn Val Leu Val Cys Ala Ala 
    50                  55                  60                  


Ile Val Arg Ser Arg His Leu Arg Ala Asn Met Thr Asn Val Phe Ile 
65                  70                  75                  80  


Val Ser Leu Ala Val Ser Asp Leu Phe Val Ala Leu Leu Val Met Pro 
                85                  90                  95      


Trp Lys Ala Val Ala Glu Val Ala Gly Tyr Trp Pro Phe Gly Ala Phe 
            100                 105                 110         


Cys Asp Val Trp Val Ala Phe Asp Ile Met Cys Ser Thr Ala Ser Ile 
        115                 120                 125             


Leu Asn Leu Cys Val Ile Ser Val Asp Arg Tyr Trp Ala Ile Ser Arg 
    130                 135                 140                 


Pro Phe Arg Tyr Lys Arg Lys Met Thr Gln Arg Met Ala Leu Val Met 
145                 150                 155                 160 


Val Gly Leu Ala Trp Thr Leu Ser Ile Leu Ile Ser Phe Ile Pro Val 
                165                 170                 175     


Gln Leu Asn Trp His Arg Asp Gln Ala Ala Ser Trp Gly Gly Leu Asp 
            180                 185                 190         


Leu Pro Asn Asn Leu Ala Asn Trp Thr Pro Trp Glu Glu Asp Phe Trp 
        195                 200                 205             


Glu Pro Asp Val Asn Ala Glu Asn Cys Asp Ser Ser Leu Asn Arg Thr 
    210                 215                 220                 


Tyr Ala Ile Ser Ser Ser Leu Ile Ser Phe Tyr Ile Pro Val Ala Ile 
225                 230                 235                 240 


Met Ile Val Thr Tyr Thr Arg Ile Tyr Arg Ile Ala Gln Val Gln Ile 
                245                 250                 255     


Arg Arg Ile Ser Ser Leu Glu Arg Ala Ala Glu His Ala Gln Ser Cys 
            260                 265                 270         


Arg Ser Ser Ala Ala Cys Ala Pro Asp Thr Ser Leu Arg Ala Ser Ile 
        275                 280                 285             


Lys Lys Glu Thr Lys Val Leu Lys Thr Leu Ser Val Ile Met Gly Val 
    290                 295                 300                 


Phe Val Cys Cys Trp Leu Pro Phe Phe Ile Leu Asn Cys Met Val Pro 
305                 310                 315                 320 


Phe Cys Ser Gly His Pro Glu Gly Pro Pro Ala Gly Phe Pro Cys Val 
                325                 330                 335     


Ser Glu Thr Thr Phe Asp Val Phe Val Trp Phe Gly Trp Ala Asn Ser 
            340                 345                 350         


Ser Leu Asn Pro Val Ile Tyr Ala Phe Asn Ala Asp Phe Gln Lys Val 
        355                 360                 365             


Phe Ala Gln Leu Leu Gly Cys Ser His Phe Cys Ser Arg Thr Pro Val 
    370                 375                 380                 


Glu Thr Val Asn Ile Ser Asn Glu Leu Ile Ser Tyr Asn Gln Asp Ile 
385                 390                 395                 400 


Val Phe His Lys Glu Ile Ala Ala Ala Tyr Ile His Met Met Pro Asn 
                405                 410                 415     


Ala Val Thr Pro Gly Asn Arg Glu Val Asp Asn Asp Glu Glu Glu Gly 
            420                 425                 430         


Pro Phe Asp Arg Met Phe Gln Ile Tyr Gln Thr Ser Pro Asp Gly Asp 
        435                 440                 445             


Pro Val Ala Glu Ser Val Trp Glu Leu Asp Cys Glu Gly Glu Ile Ser 
    450                 455                 460                 


Leu Asp Lys Ile Thr Pro Phe Thr Pro Asn Gly Phe His 
465                 470                 475         


<210>  258
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  258

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu 
            20                  25                  30          


Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu Leu Glu Ala Lys Glu 
        35                  40                  45              


Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His Cys Ser Leu Asn Glu 
    50                  55                  60                  


Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp Lys Arg 
65                  70                  75                  80  


Met Glu Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu 
                85                  90                  95      


Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu Leu Val Asn Ser Ser 
            100                 105                 110         


Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp Lys Ala Val Ser Gly 
        115                 120                 125             


Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu 
    130                 135                 140                 


Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr Ile 
145                 150                 155                 160 


Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn Phe Leu 
                165                 170                 175     


Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr Gly Asp 
            180                 185                 190         


Arg 
    


<210>  259
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  259

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105             


<210>  260
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  260

Met Ala Gln Arg Met Thr Thr Gln Leu Leu Leu Leu Leu Val Trp Val 
1               5                   10                  15      


Ala Val Val Gly Glu Ala Gln Thr Arg Ile Ala Trp Ala Arg Thr Glu 
            20                  25                  30          


Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly 
        35                  40                  45              


Pro Glu Asp Lys Leu His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala 
    50                  55                  60                  


Cys Cys Ser Thr Asn Thr Ser Gln Glu Ala His Lys Asp Val Ser Tyr 
65                  70                  75                  80  


Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Cys 
                85                  90                  95      


Lys Arg His Phe Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn 
            100                 105                 110         


Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg 
        115                 120                 125             


Val Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Gln Trp Trp Glu 
    130                 135                 140                 


Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp 
145                 150                 155                 160 


Asn Trp Thr Ser Gly Phe Asn Lys Cys Ala Val Gly Ala Ala Cys Gln 
                165                 170                 175     


Pro Phe His Phe Tyr Phe Pro Thr Pro Thr Val Leu Cys Asn Glu Ile 
            180                 185                 190         


Trp Thr His Ser Tyr Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg 
        195                 200                 205             


Cys Ile Gln Met Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu Glu 
    210                 215                 220                 


Val Ala Arg Phe Tyr Ala Ala Ala Met Ser Gly Ala Gly Pro Trp Ala 
225                 230                 235                 240 


Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu 
                245                 250                 255     


Ser 
    


<210>  261
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  261

Met Val Trp Lys Trp Met Pro Leu Leu Leu Leu Leu Val Cys Val Ala 
1               5                   10                  15      


Thr Met Cys Ser Ala Gln Asp Arg Thr Asp Leu Leu Asn Val Cys Met 
            20                  25                  30          


Asp Ala Lys His His Lys Thr Lys Pro Gly Pro Glu Asp Lys Leu His 
        35                  40                  45              


Asp Gln Cys Ser Pro Trp Lys Lys Asn Ala Cys Cys Thr Ala Ser Thr 
    50                  55                  60                  


Ser Gln Glu Leu His Lys Asp Thr Ser Arg Leu Tyr Asn Phe Asn Trp 
65                  70                  75                  80  


Asp His Cys Gly Lys Met Glu Pro Ala Cys Lys Arg His Phe Ile Gln 
                85                  90                  95      


Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn Leu Gly Pro Trp Ile Gln 
            100                 105                 110         


Gln Val Asn Gln Ser Trp Arg Lys Glu Arg Phe Leu Asp Val Pro Leu 
        115                 120                 125             


Cys Lys Glu Asp Cys Gln Arg Trp Trp Glu Asp Cys His Thr Ser His 
    130                 135                 140                 


Thr Cys Lys Ser Asn Trp His Arg Gly Trp Asp Trp Thr Ser Gly Val 
145                 150                 155                 160 


Asn Lys Cys Pro Ala Gly Ala Leu Cys Arg Thr Phe Glu Ser Tyr Phe 
                165                 170                 175     


Pro Thr Pro Ala Ala Leu Cys Glu Gly Leu Trp Ser His Ser Tyr Lys 
            180                 185                 190         


Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg Cys Ile Gln Met Trp Phe 
        195                 200                 205             


Asp Ser Ala Gln Gly Asn Pro Asn Glu Glu Val Ala Arg Phe Tyr Ala 
    210                 215                 220                 


Ala Ala Met His Val Asn Ala Gly Glu Met Leu His Gly Thr Gly Gly 
225                 230                 235                 240 


Leu Leu Leu Ser Leu Ala Leu Met Leu Gln Leu Trp Leu Leu Gly 
                245                 250                 255 


<210>  262
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  262

Met Arg Lys Ser Pro Gly Leu Ser Asp Cys Leu Trp Ala Trp Ile Leu 
1               5                   10                  15      


Leu Leu Ser Thr Leu Thr Gly Arg Ser Tyr Gly Gln Pro Ser Leu Gln 
            20                  25                  30          


Asp Glu Leu Lys Asp Asn Thr Thr Val Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Glu Arg 
    50                  55                  60                  


Val Thr Glu Val Lys Thr Asp Ile Phe Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp His Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Ser 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Thr Val Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Thr Glu Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Arg Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ala Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Arg Ala 
            180                 185                 190         


Glu Val Val Tyr Glu Trp Thr Arg Glu Pro Ala Arg Ser Val Val Val 
        195                 200                 205             


Ala Glu Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Thr 
    210                 215                 220                 


Val Asp Ser Gly Ile Val Gln Ser Ser Thr Gly Glu Tyr Val Val Met 
225                 230                 235                 240 


Thr Thr His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285             


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300                 


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320 


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335     


Phe Thr Lys Arg Gly Tyr Ala Trp Asp Gly Lys Ser Val Val Pro Glu 
            340                 345                 350         


Lys Pro Lys Lys Val Lys Asp Pro Leu Ile Lys Lys Asn Asn Thr Tyr 
        355                 360                 365             


Ala Pro Thr Ala Thr Ser Tyr Thr Pro Asn Leu Ala Arg Gly Asp Pro 
    370                 375                 380                 


Gly Leu Ala Thr Ile Ala Lys Ser Ala Thr Ile Glu Pro Lys Glu Val 
385                 390                 395                 400 


Lys Pro Glu Thr Lys Pro Pro Glu Pro Lys Lys Thr Phe Asn Ser Val 
                405                 410                 415     


Ser Lys Ile Asp Arg Leu Ser Arg Ile Ala Phe Pro Leu Leu Phe Gly 
            420                 425                 430         


Ile Phe Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Gln 
        435                 440                 445             


Leu Lys Ala Pro Thr Pro His Gln 
    450                 455     


<210>  263
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  263

Met Lys Thr Lys Leu Asn Ile Tyr Asn Met Gln Phe Leu Leu Phe Val 
1               5                   10                  15      


Phe Leu Val Trp Asp Pro Ala Arg Leu Val Leu Ala Asn Ile Gln Glu 
            20                  25                  30          


Asp Glu Ala Lys Asn Asn Ile Thr Ile Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Asp Ser 
    50                  55                  60                  


Ile Thr Glu Val Phe Thr Asn Ile Tyr Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp Thr Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Lys 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Asn Ile Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Gln Asp Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Gln Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ser Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Thr Ser 
            180                 185                 190         


Glu Val Thr Tyr Ile Trp Thr Tyr Asn Ala Ser Asp Ser Val Gln Val 
        195                 200                 205             


Ala Pro Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Ser 
    210                 215                 220                 


Ile Gly Lys Glu Thr Ile Lys Ser Ser Thr Gly Glu Tyr Thr Val Met 
225                 230                 235                 240 


Thr Ala His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285             


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300                 


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320 


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335     


Phe Thr Lys Arg Gly Trp Ala Trp Asp Gly Lys Ser Val Val Asn Asp 
            340                 345                 350         


Lys Lys Lys Glu Lys Ala Ser Val Met Ile Gln Asn Asn Ala Tyr Ala 
        355                 360                 365             


Val Ala Val Ala Asn Tyr Ala Pro Asn Leu Ser Lys Asp Pro Val Leu 
    370                 375                 380                 


Ser Thr Ile Ser Lys Ser Ala Thr Thr Pro Glu Pro Asn Lys Lys Pro 
385                 390                 395                 400 


Glu Asn Lys Pro Ala Glu Ala Lys Lys Thr Phe Asn Ser Val Ser Lys 
                405                 410                 415     


Ile Asp Arg Met Ser Arg Ile Val Phe Pro Val Leu Phe Gly Thr Phe 
            420                 425                 430         


Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Val Leu Gly 
        435                 440                 445             


Val Ser Pro 
    450     


<210>  264
<211>  492
<212>  PRT
<213>  Homo sapiens

<400>  264

Met Ile Ile Thr Gln Thr Ser His Cys Tyr Met Thr Ser Leu Gly Ile 
1               5                   10                  15      


Leu Phe Leu Ile Asn Ile Leu Pro Gly Thr Thr Gly Gln Gly Glu Ser 
            20                  25                  30          


Arg Arg Gln Glu Pro Gly Asp Phe Val Lys Gln Asp Ile Gly Gly Leu 
        35                  40                  45              


Ser Pro Lys His Ala Pro Asp Ile Pro Asp Asp Ser Thr Asp Asn Ile 
    50                  55                  60                  


Thr Ile Phe Thr Arg Ile Leu Asp Arg Leu Leu Asp Gly Tyr Asp Asn 
65                  70                  75                  80  


Arg Leu Arg Pro Gly Leu Gly Asp Ala Val Thr Glu Val Lys Thr Asp 
                85                  90                  95      


Ile Tyr Val Thr Ser Phe Gly Pro Val Ser Asp Thr Asp Met Glu Tyr 
            100                 105                 110         


Thr Ile Asp Val Phe Phe Arg Gln Thr Trp His Asp Glu Arg Leu Lys 
        115                 120                 125             


Phe Asp Gly Pro Met Lys Ile Leu Pro Leu Asn Asn Leu Leu Ala Ser 
    130                 135                 140                 


Lys Ile Trp Thr Pro Asp Thr Phe Phe His Asn Gly Lys Lys Ser Val 
145                 150                 155                 160 


Ala His Asn Met Thr Thr Pro Asn Lys Leu Leu Arg Leu Val Asp Asn 
                165                 170                 175     


Gly Thr Leu Leu Tyr Thr Met Arg Leu Thr Ile His Ala Glu Cys Pro 
            180                 185                 190         


Met His Leu Glu Asp Phe Pro Met Asp Val His Ala Cys Pro Leu Lys 
        195                 200                 205             


Phe Gly Ser Tyr Ala Tyr Thr Thr Ala Glu Val Val Tyr Ser Trp Thr 
    210                 215                 220                 


Leu Gly Lys Asn Lys Ser Val Glu Val Ala Gln Asp Gly Ser Arg Leu 
225                 230                 235                 240 


Asn Gln Tyr Asp Leu Leu Gly His Val Val Gly Thr Glu Ile Ile Arg 
                245                 250                 255     


Ser Ser Thr Gly Glu Tyr Val Val Met Thr Thr His Phe His Leu Lys 
            260                 265                 270         


Arg Lys Ile Gly Tyr Phe Val Ile Gln Thr Tyr Leu Pro Cys Ile Met 
        275                 280                 285             


Thr Val Ile Leu Ser Gln Val Ser Phe Trp Leu Asn Arg Glu Ser Val 
    290                 295                 300                 


Pro Ala Arg Thr Val Phe Gly Val Thr Thr Val Leu Thr Met Thr Thr 
305                 310                 315                 320 


Leu Ser Ile Ser Ala Arg Asn Ser Leu Pro Lys Val Ala Tyr Ala Thr 
                325                 330                 335     


Ala Met Asp Trp Phe Ile Ala Val Cys Tyr Ala Phe Val Phe Ser Ala 
            340                 345                 350         


Leu Ile Glu Phe Ala Thr Val Asn Tyr Phe Thr Lys Arg Ser Trp Ala 
        355                 360                 365             


Trp Glu Gly Lys Lys Val Pro Glu Ala Leu Glu Met Lys Lys Lys Thr 
    370                 375                 380                 


Pro Ala Ala Pro Ala Lys Lys Thr Ser Thr Thr Phe Asn Ile Val Gly 
385                 390                 395                 400 


Thr Thr Tyr Pro Ile Asn Leu Ala Lys Asp Thr Glu Phe Ser Thr Ile 
                405                 410                 415     


Ser Lys Gly Ala Ala Pro Ser Ala Ser Ser Thr Pro Thr Ile Ile Ala 
            420                 425                 430         


Ser Pro Lys Ala Thr Tyr Val Gln Asp Ser Pro Thr Glu Thr Lys Thr 
        435                 440                 445             


Tyr Asn Ser Val Ser Lys Val Asp Lys Ile Ser Arg Ile Ile Phe Pro 
    450                 455                 460                 


Val Leu Phe Ala Ile Phe Asn Leu Val Tyr Trp Ala Thr Tyr Val Asn 
465                 470                 475                 480 


Arg Glu Ser Ala Ile Lys Gly Met Ile Arg Lys Gln 
                485                 490         


<210>  265
<211>  554
<212>  PRT
<213>  Homo sapiens

<400>  265

Met Val Ser Ala Lys Lys Val Pro Ala Ile Ala Leu Ser Ala Gly Val 
1               5                   10                  15      


Ser Phe Ala Leu Leu Arg Phe Leu Cys Leu Ala Val Cys Leu Asn Glu 
            20                  25                  30          


Ser Pro Gly Gln Asn Gln Lys Glu Glu Lys Leu Cys Thr Glu Asn Phe 
        35                  40                  45              


Thr Arg Ile Leu Asp Ser Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg 
    50                  55                  60                  


Pro Gly Phe Gly Gly Pro Val Thr Glu Val Lys Thr Asp Ile Tyr Val 
65                  70                  75                  80  


Thr Ser Phe Gly Pro Val Ser Asp Val Glu Met Glu Tyr Thr Met Asp 
                85                  90                  95      


Val Phe Phe Arg Gln Thr Trp Ile Asp Lys Arg Leu Lys Tyr Asp Gly 
            100                 105                 110         


Pro Ile Glu Ile Leu Arg Leu Asn Asn Met Met Val Thr Lys Val Trp 
        115                 120                 125             


Thr Pro Asp Thr Phe Phe Arg Asn Gly Lys Lys Ser Val Ser His Asn 
    130                 135                 140                 


Met Thr Ala Pro Asn Lys Leu Phe Arg Ile Met Arg Asn Gly Thr Ile 
145                 150                 155                 160 


Leu Tyr Thr Met Arg Leu Thr Ile Ser Ala Glu Cys Pro Met Arg Leu 
                165                 170                 175     


Val Asp Phe Pro Met Asp Gly His Ala Cys Pro Leu Lys Phe Gly Ser 
            180                 185                 190         


Tyr Ala Tyr Pro Lys Ser Glu Met Ile Tyr Thr Trp Thr Lys Gly Pro 
        195                 200                 205             


Glu Lys Ser Val Glu Val Pro Lys Glu Ser Ser Ser Leu Val Gln Tyr 
    210                 215                 220                 


Asp Leu Ile Gly Gln Thr Val Ser Ser Glu Thr Ile Lys Ser Ile Thr 
225                 230                 235                 240 


Gly Glu Tyr Ile Val Met Thr Val Tyr Phe His Leu Arg Arg Lys Met 
                245                 250                 255     


Gly Tyr Phe Met Ile Gln Thr Tyr Ile Pro Cys Ile Met Thr Val Ile 
            260                 265                 270         


Leu Ser Gln Val Ser Phe Trp Ile Asn Lys Glu Ser Val Pro Ala Arg 
        275                 280                 285             


Thr Val Phe Gly Ile Thr Thr Val Leu Thr Met Thr Thr Leu Ser Ile 
    290                 295                 300                 


Ser Ala Arg His Ser Leu Pro Lys Val Ser Tyr Ala Thr Ala Met Asp 
305                 310                 315                 320 


Trp Phe Ile Ala Val Cys Phe Ala Phe Val Phe Ser Ala Leu Ile Glu 
                325                 330                 335     


Phe Ala Ala Val Asn Tyr Phe Thr Asn Ile Gln Met Glu Lys Ala Lys 
            340                 345                 350         


Arg Lys Thr Ser Lys Pro Pro Gln Glu Val Pro Ala Ala Pro Val Gln 
        355                 360                 365             


Arg Glu Lys His Pro Glu Ala Pro Leu Gln Asn Thr Asn Ala Asn Leu 
    370                 375                 380                 


Asn Met Arg Lys Arg Thr Asn Ala Leu Val His Ser Glu Ser Asp Val 
385                 390                 395                 400 


Gly Asn Arg Thr Glu Val Gly Asn His Ser Ser Lys Ser Ser Thr Val 
                405                 410                 415     


Val Gln Glu Ser Ser Lys Gly Thr Pro Arg Ser Tyr Leu Ala Ser Ser 
            420                 425                 430         


Pro Asn Pro Phe Ser Arg Ala Asn Ala Ala Glu Thr Ile Ser Ala Ala 
        435                 440                 445             


Arg Ala Leu Pro Ser Ala Ser Pro Thr Ser Ile Arg Thr Gly Tyr Met 
    450                 455                 460                 


Pro Arg Lys Ala Ser Val Gly Ser Ala Ser Thr Arg His Val Phe Gly 
465                 470                 475                 480 


Ser Arg Leu Gln Arg Ile Lys Thr Thr Val Asn Thr Ile Gly Ala Thr 
                485                 490                 495     


Gly Lys Leu Ser Ala Thr Pro Pro Pro Ser Ala Pro Pro Pro Ser Gly 
            500                 505                 510         


Ser Gly Thr Ser Lys Ile Asp Lys Tyr Ala Arg Ile Leu Phe Pro Val 
        515                 520                 525             


Thr Phe Gly Ala Phe Asn Met Val Tyr Trp Val Val Tyr Leu Ser Lys 
    530                 535                 540                 


Asp Thr Met Glu Lys Ser Glu Ser Leu Met 
545                 550                 


<210>  266
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  266

Met Asp Asn Gly Met Phe Ser Gly Phe Ile Met Ile Lys Asn Leu Leu 
1               5                   10                  15      


Leu Phe Cys Ile Ser Met Asn Leu Ser Ser His Phe Gly Phe Ser Gln 
            20                  25                  30          


Met Pro Thr Ser Ser Val Lys Asp Glu Thr Asn Asp Asn Ile Thr Ile 
        35                  40                  45              


Phe Thr Arg Ile Leu Asp Gly Leu Leu Asp Gly Tyr Asp Asn Arg Leu 
    50                  55                  60                  


Arg Pro Gly Leu Gly Glu Arg Ile Thr Gln Val Arg Thr Asp Ile Tyr 
65                  70                  75                  80  


Val Thr Ser Phe Gly Pro Val Ser Asp Thr Glu Met Glu Tyr Thr Ile 
                85                  90                  95      


Asp Val Phe Phe Arg Gln Ser Trp Lys Asp Glu Arg Leu Arg Phe Lys 
            100                 105                 110         


Gly Pro Met Gln Arg Leu Pro Leu Asn Asn Leu Leu Ala Ser Lys Ile 
        115                 120                 125             


Trp Thr Pro Asp Thr Phe Phe His Asn Gly Lys Lys Ser Ile Ala His 
    130                 135                 140                 


Asn Met Thr Thr Pro Asn Lys Leu Leu Arg Leu Glu Asp Asp Gly Thr 
145                 150                 155                 160 


Leu Leu Tyr Thr Met Arg Leu Thr Ile Ser Ala Glu Cys Pro Met Gln 
                165                 170                 175     


Leu Glu Asp Phe Pro Met Asp Ala His Ala Cys Pro Leu Lys Phe Gly 
            180                 185                 190         


Ser Tyr Ala Tyr Pro Asn Ser Glu Val Val Tyr Val Trp Thr Asn Gly 
        195                 200                 205             


Ser Thr Lys Ser Val Val Val Ala Glu Asp Gly Ser Arg Leu Asn Gln 
    210                 215                 220                 


Tyr His Leu Met Gly Gln Thr Val Gly Thr Glu Asn Ile Ser Thr Ser 
225                 230                 235                 240 


Thr Gly Glu Tyr Thr Ile Met Thr Ala His Phe His Leu Lys Arg Lys 
                245                 250                 255     


Ile Gly Tyr Phe Val Ile Gln Thr Tyr Leu Pro Cys Ile Met Thr Val 
            260                 265                 270         


Ile Leu Ser Gln Val Ser Phe Trp Leu Asn Arg Glu Ser Val Pro Ala 
        275                 280                 285             


Arg Thr Val Phe Gly Val Thr Thr Val Leu Thr Met Thr Thr Leu Ser 
    290                 295                 300                 


Ile Ser Ala Arg Asn Ser Leu Pro Lys Val Ala Tyr Ala Thr Ala Met 
305                 310                 315                 320 


Asp Trp Phe Ile Ala Val Cys Tyr Ala Phe Val Phe Ser Ala Leu Ile 
                325                 330                 335     


Glu Phe Ala Thr Val Asn Tyr Phe Thr Lys Arg Gly Trp Ala Trp Asp 
            340                 345                 350         


Gly Lys Lys Ala Leu Glu Ala Ala Lys Ile Lys Lys Lys Arg Glu Val 
        355                 360                 365             


Ile Leu Asn Lys Ser Thr Asn Ala Phe Thr Thr Gly Lys Met Ser His 
    370                 375                 380                 


Pro Pro Asn Ile Pro Lys Glu Gln Thr Pro Ala Gly Thr Ser Asn Thr 
385                 390                 395                 400 


Thr Ser Val Ser Val Lys Pro Ser Glu Glu Lys Thr Ser Glu Ser Lys 
                405                 410                 415     


Lys Thr Tyr Asn Ser Ile Ser Lys Ile Asp Lys Met Ser Arg Ile Val 
            420                 425                 430         


Phe Pro Val Leu Phe Gly Thr Phe Asn Leu Val Tyr Trp Ala Thr Tyr 
        435                 440                 445             


Leu Asn Arg Glu Pro Val Ile Lys Gly Ala Ala Ser Pro Lys 
    450                 455                 460         


<210>  267
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  267

Met Ala Ser Ser Leu Pro Trp Leu Cys Ile Ile Leu Trp Leu Glu Asn 
1               5                   10                  15      


Ala Leu Gly Lys Leu Glu Val Glu Gly Asn Phe Tyr Ser Glu Asn Val 
            20                  25                  30          


Ser Arg Ile Leu Asp Asn Leu Leu Glu Gly Tyr Asp Asn Arg Leu Arg 
        35                  40                  45              


Pro Gly Phe Gly Gly Ala Val Thr Glu Val Lys Thr Asp Ile Tyr Val 
    50                  55                  60                  


Thr Ser Phe Gly Pro Val Ser Asp Val Glu Met Glu Tyr Thr Met Asp 
65                  70                  75                  80  


Val Phe Phe Arg Gln Thr Trp Thr Asp Glu Arg Leu Lys Phe Gly Gly 
                85                  90                  95      


Pro Thr Glu Ile Leu Ser Leu Asn Asn Leu Met Val Ser Lys Ile Trp 
            100                 105                 110         


Thr Pro Asp Thr Phe Phe Arg Asn Gly Lys Lys Ser Ile Ala His Asn 
        115                 120                 125             


Met Thr Thr Pro Asn Lys Leu Phe Arg Ile Met Gln Asn Gly Thr Ile 
    130                 135                 140                 


Leu Tyr Thr Met Arg Leu Thr Ile Asn Ala Asp Cys Pro Met Arg Leu 
145                 150                 155                 160 


Val Asn Phe Pro Met Asp Gly His Ala Cys Pro Leu Lys Phe Gly Ser 
                165                 170                 175     


Tyr Ala Tyr Pro Lys Ser Glu Ile Ile Tyr Thr Trp Lys Lys Gly Pro 
            180                 185                 190         


Leu Tyr Ser Val Glu Val Pro Glu Glu Ser Ser Ser Leu Leu Gln Tyr 
        195                 200                 205             


Asp Leu Ile Gly Gln Thr Val Ser Ser Glu Thr Ile Lys Ser Asn Thr 
    210                 215                 220                 


Gly Glu Tyr Val Ile Met Thr Val Tyr Phe His Leu Gln Arg Lys Met 
225                 230                 235                 240 


Gly Tyr Phe Met Ile Gln Ile Tyr Thr Pro Cys Ile Met Thr Val Ile 
                245                 250                 255     


Leu Ser Gln Val Ser Phe Trp Ile Asn Lys Glu Ser Val Pro Ala Arg 
            260                 265                 270         


Thr Val Phe Gly Ile Thr Thr Val Leu Thr Met Thr Thr Leu Ser Ile 
        275                 280                 285             


Ser Ala Arg His Ser Leu Pro Lys Val Ser Tyr Ala Thr Ala Met Asp 
    290                 295                 300                 


Trp Phe Ile Ala Val Cys Phe Ala Phe Val Phe Ser Ala Leu Ile Glu 
305                 310                 315                 320 


Phe Ala Ala Val Asn Tyr Phe Thr Asn Leu Gln Thr Gln Lys Ala Lys 
                325                 330                 335     


Arg Lys Ala Gln Phe Ala Ala Pro Pro Thr Val Thr Ile Ser Lys Ala 
            340                 345                 350         


Thr Glu Pro Leu Glu Ala Glu Ile Val Leu His Pro Asp Ser Lys Tyr 
        355                 360                 365             


His Leu Lys Lys Arg Ile Thr Ser Leu Ser Leu Pro Ile Val Ser Ser 
    370                 375                 380                 


Ser Glu Ala Asn Lys Val Leu Thr Arg Ala Pro Ile Leu Gln Ser Thr 
385                 390                 395                 400 


Pro Val Thr Pro Pro Pro Leu Ser Pro Ala Phe Gly Gly Thr Ser Lys 
                405                 410                 415     


Ile Asp Gln Tyr Ser Arg Ile Leu Phe Pro Val Ala Phe Ala Gly Phe 
            420                 425                 430         


Asn Leu Val Tyr Trp Val Val Tyr Leu Ser Lys Asp Thr Met Glu Val 
        435                 440                 445             


Ser Ser Ser Val Glu 
    450             


<210>  268
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  268

Met Trp Thr Val Gln Asn Arg Glu Ser Leu Gly Leu Leu Ser Phe Pro 
1               5                   10                  15      


Val Met Ile Thr Met Val Cys Cys Ala His Ser Thr Asn Glu Pro Ser 
            20                  25                  30          


Asn Met Ser Tyr Val Lys Glu Thr Val Asp Arg Leu Leu Lys Gly Tyr 
        35                  40                  45              


Asp Ile Arg Leu Arg Pro Asp Phe Gly Gly Pro Pro Val Asp Val Gly 
    50                  55                  60                  


Met Arg Ile Asp Val Ala Ser Ile Asp Met Val Ser Glu Val Asn Met 
65                  70                  75                  80  


Asp Tyr Thr Leu Thr Met Tyr Phe Gln Gln Ser Trp Lys Asp Lys Arg 
                85                  90                  95      


Leu Ser Tyr Ser Gly Ile Pro Leu Asn Leu Thr Leu Asp Asn Arg Val 
            100                 105                 110         


Ala Asp Gln Leu Trp Val Pro Asp Thr Tyr Phe Leu Asn Asp Lys Lys 
        115                 120                 125             


Ser Phe Val His Gly Val Thr Val Lys Asn Arg Met Ile Arg Leu His 
    130                 135                 140                 


Pro Asp Gly Thr Val Leu Tyr Gly Leu Arg Ile Thr Thr Thr Ala Ala 
145                 150                 155                 160 


Cys Met Met Asp Leu Arg Arg Tyr Pro Leu Asp Glu Gln Asn Cys Thr 
                165                 170                 175     


Leu Glu Ile Glu Ser Tyr Gly Tyr Thr Thr Asp Asp Ile Glu Phe Tyr 
            180                 185                 190         


Trp Asn Gly Gly Glu Gly Ala Val Thr Gly Val Asn Lys Ile Glu Leu 
        195                 200                 205             


Pro Gln Phe Ser Ile Val Asp Tyr Lys Met Val Ser Lys Lys Val Glu 
    210                 215                 220                 


Phe Thr Thr Gly Ala Tyr Pro Arg Leu Ser Leu Ser Phe Arg Leu Lys 
225                 230                 235                 240 


Arg Asn Ile Gly Tyr Phe Ile Leu Gln Thr Tyr Met Pro Ser Thr Leu 
                245                 250                 255     


Ile Thr Ile Leu Ser Trp Val Ser Phe Trp Ile Asn Tyr Asp Ala Ser 
            260                 265                 270         


Ala Ala Arg Val Ala Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr 
        275                 280                 285             


Ile Ser Thr His Leu Arg Glu Thr Leu Pro Lys Ile Pro Tyr Val Lys 
    290                 295                 300                 


Ala Ile Asp Ile Tyr Leu Met Gly Cys Phe Val Phe Val Phe Leu Ala 
305                 310                 315                 320 


Leu Leu Glu Tyr Ala Phe Val Asn Tyr Ile Phe Phe Gly Lys Gly Pro 
                325                 330                 335     


Gln Lys Lys Gly Ala Ser Lys Gln Asp Gln Ser Ala Asn Glu Lys Asn 
            340                 345                 350         


Lys Leu Glu Met Asn Lys Val Gln Val Asp Ala His Gly Asn Ile Leu 
        355                 360                 365             


Leu Ser Thr Leu Glu Ile Arg Asn Glu Thr Ser Gly Ser Glu Val Leu 
    370                 375                 380                 


Thr Ser Val Ser Asp Pro Lys Ala Thr Met Tyr Ser Tyr Asp Ser Ala 
385                 390                 395                 400 


Ser Ile Gln Tyr Arg Lys Pro Leu Ser Ser Arg Glu Ala Tyr Gly Arg 
                405                 410                 415     


Ala Leu Asp Arg His Gly Val Pro Ser Lys Gly Arg Ile Arg Arg Arg 
            420                 425                 430         


Ala Ser Gln Leu Lys Val Lys Ile Pro Asp Leu Thr Asp Val Asn Ser 
        435                 440                 445             


Ile Asp Lys Trp Ser Arg Met Phe Phe Pro Ile Thr Phe Ser Leu Phe 
    450                 455                 460                 


Asn Val Val Tyr Trp Leu Tyr Tyr Val His 
465                 470                 


<210>  269
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  269

Met Trp Arg Val Arg Lys Arg Gly Tyr Phe Gly Ile Trp Ser Phe Pro 
1               5                   10                  15      


Leu Ile Ile Ala Ala Val Cys Ala Gln Ser Val Asn Asp Pro Ser Asn 
            20                  25                  30          


Met Ser Leu Val Lys Glu Thr Val Asp Arg Leu Leu Lys Gly Tyr Asp 
        35                  40                  45              


Ile Arg Leu Arg Pro Asp Phe Gly Gly Pro Pro Val Ala Val Gly Met 
    50                  55                  60                  


Asn Ile Asp Ile Ala Ser Ile Asp Met Val Ser Glu Val Asn Met Asp 
65                  70                  75                  80  


Tyr Thr Leu Thr Met Tyr Phe Gln Gln Ala Trp Arg Asp Lys Arg Leu 
                85                  90                  95      


Ser Tyr Asn Val Ile Pro Leu Asn Leu Thr Leu Asp Asn Arg Val Ala 
            100                 105                 110         


Asp Gln Leu Trp Val Pro Asp Thr Tyr Phe Leu Asn Asp Lys Lys Ser 
        115                 120                 125             


Phe Val His Gly Val Thr Val Lys Asn Arg Met Ile Arg Leu His Pro 
    130                 135                 140                 


Asp Gly Thr Val Leu Tyr Gly Leu Arg Ile Thr Thr Thr Ala Ala Cys 
145                 150                 155                 160 


Met Met Asp Leu Arg Arg Tyr Pro Leu Asp Glu Gln Asn Cys Thr Leu 
                165                 170                 175     


Glu Ile Glu Ser Tyr Gly Tyr Thr Thr Asp Asp Ile Glu Phe Tyr Trp 
            180                 185                 190         


Arg Gly Asp Asp Asn Ala Val Thr Gly Val Thr Lys Ile Glu Leu Pro 
        195                 200                 205             


Gln Phe Ser Ile Val Asp Tyr Lys Leu Ile Thr Lys Lys Val Val Phe 
    210                 215                 220                 


Ser Thr Gly Ser Tyr Pro Arg Leu Ser Leu Ser Phe Lys Leu Lys Arg 
225                 230                 235                 240 


Asn Ile Gly Tyr Phe Ile Leu Gln Thr Tyr Met Pro Ser Ile Leu Ile 
                245                 250                 255     


Thr Ile Leu Ser Trp Val Ser Phe Trp Ile Asn Tyr Asp Ala Ser Ala 
            260                 265                 270         


Ala Arg Val Ala Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr Ile 
        275                 280                 285             


Asn Thr His Leu Arg Glu Thr Leu Pro Lys Ile Pro Tyr Val Lys Ala 
    290                 295                 300                 


Ile Asp Met Tyr Leu Met Gly Cys Phe Val Phe Val Phe Met Ala Leu 
305                 310                 315                 320 


Leu Glu Tyr Ala Leu Val Asn Tyr Ile Phe Phe Gly Arg Gly Pro Gln 
                325                 330                 335     


Arg Gln Lys Lys Ala Ala Glu Lys Ala Ala Ser Ala Asn Asn Glu Lys 
            340                 345                 350         


Met Arg Leu Asp Val Asn Lys Met Asp Pro His Glu Asn Ile Leu Leu 
        355                 360                 365             


Ser Thr Leu Glu Ile Lys Asn Glu Met Ala Thr Ser Glu Ala Val Met 
    370                 375                 380                 


Gly Leu Gly Asp Pro Arg Ser Thr Met Leu Ala Tyr Asp Ala Ser Ser 
385                 390                 395                 400 


Ile Gln Tyr Arg Lys Ala Gly Leu Pro Arg His Ser Phe Gly Arg Asn 
                405                 410                 415     


Ala Leu Glu Arg His Val Ala Gln Lys Lys Ser Arg Leu Arg Arg Arg 
            420                 425                 430         


Ala Ser Gln Leu Lys Ile Thr Ile Pro Asp Leu Thr Asp Val Asn Ala 
        435                 440                 445             


Ile Asp Arg Trp Ser Arg Ile Phe Phe Pro Val Val Phe Ser Phe Phe 
    450                 455                 460                 


Asn Ile Val Tyr Trp Leu Tyr Tyr Val Asn 
465                 470                 


<210>  270
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  270

Met Trp Gly Leu Ala Gly Gly Arg Leu Phe Gly Ile Phe Ser Ala Pro 
1               5                   10                  15      


Val Leu Val Ala Val Val Cys Cys Ala Gln Ser Val Asn Asp Pro Gly 
            20                  25                  30          


Asn Met Ser Phe Val Lys Glu Thr Val Asp Lys Leu Leu Lys Gly Tyr 
        35                  40                  45              


Asp Ile Arg Leu Arg Pro Asp Phe Gly Gly Pro Pro Val Cys Val Gly 
    50                  55                  60                  


Met Asn Ile Asp Ile Ala Ser Ile Asp Met Val Ser Glu Val Asn Met 
65                  70                  75                  80  


Asp Tyr Thr Leu Thr Met Tyr Phe Gln Gln Tyr Trp Arg Asp Lys Arg 
                85                  90                  95      


Leu Ala Tyr Ser Gly Ile Pro Leu Asn Leu Thr Leu Asp Asn Arg Val 
            100                 105                 110         


Ala Asp Gln Leu Trp Val Pro Asp Thr Tyr Phe Leu Asn Asp Lys Lys 
        115                 120                 125             


Ser Phe Val His Gly Val Thr Val Lys Asn Arg Met Ile Arg Leu His 
    130                 135                 140                 


Pro Asp Gly Thr Val Leu Tyr Gly Leu Arg Ile Thr Thr Thr Ala Ala 
145                 150                 155                 160 


Cys Met Met Asp Leu Arg Arg Tyr Pro Leu Asp Glu Gln Asn Cys Thr 
                165                 170                 175     


Leu Glu Ile Glu Ser Tyr Gly Tyr Thr Thr Asp Asp Ile Glu Phe Tyr 
            180                 185                 190         


Trp Arg Gly Gly Asp Lys Ala Val Thr Gly Val Glu Arg Ile Glu Leu 
        195                 200                 205             


Pro Gln Phe Ser Ile Val Glu His Arg Leu Val Ser Arg Asn Val Val 
    210                 215                 220                 


Phe Ala Thr Gly Ala Tyr Pro Arg Leu Ser Leu Ser Phe Arg Leu Lys 
225                 230                 235                 240 


Arg Asn Ile Gly Tyr Phe Ile Leu Gln Thr Tyr Met Pro Ser Ile Leu 
                245                 250                 255     


Ile Thr Ile Leu Ser Trp Val Ser Phe Trp Ile Asn Tyr Asp Ala Ser 
            260                 265                 270         


Ala Ala Arg Val Ala Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr 
        275                 280                 285             


Ile Asn Thr His Leu Arg Glu Thr Leu Pro Lys Ile Pro Tyr Val Lys 
    290                 295                 300                 


Ala Ile Asp Met Tyr Leu Met Gly Cys Phe Val Phe Val Phe Leu Ala 
305                 310                 315                 320 


Leu Leu Glu Tyr Ala Phe Val Asn Tyr Ile Phe Phe Gly Arg Gly Pro 
                325                 330                 335     


Gln Arg Gln Lys Lys Leu Ala Glu Lys Thr Ala Lys Ala Lys Asn Asp 
            340                 345                 350         


Arg Ser Lys Ser Glu Ser Asn Arg Val Asp Ala His Gly Asn Ile Leu 
        355                 360                 365             


Leu Thr Ser Leu Glu Val His Asn Glu Met Asn Glu Val Ser Gly Gly 
    370                 375                 380                 


Ile Gly Asp Thr Arg Asn Ser Ala Ile Ser Phe Asp Asn Ser Gly Ile 
385                 390                 395                 400 


Gln Tyr Arg Lys Gln Ser Met Pro Arg Glu Gly His Gly Arg Phe Leu 
                405                 410                 415     


Gly Asp Arg Ser Leu Pro His Lys Lys Thr His Leu Arg Arg Arg Ser 
            420                 425                 430         


Ser Gln Leu Lys Ile Lys Ile Pro Asp Leu Thr Asp Val Asn Ala Ile 
        435                 440                 445             


Asp Arg Trp Ser Arg Ile Val Phe Pro Phe Thr Phe Ser Leu Phe Asn 
    450                 455                 460                 


Leu Val Tyr Trp Leu Tyr Tyr Val Asn 
465                 470             


<210>  271
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  271

Met Asp Ala Pro Ala Arg Leu Leu Ala Pro Leu Leu Leu Leu Cys Ala 
1               5                   10                  15      


Gln Gln Leu Arg Gly Thr Arg Ala Met Asn Asp Ile Gly Asp Tyr Val 
            20                  25                  30          


Gly Ser Asn Leu Glu Ile Ser Trp Leu Pro Asn Leu Asp Gly Leu Ile 
        35                  40                  45              


Ala Gly Tyr Ala Arg Asn Phe Arg Pro Gly Ile Gly Gly Pro Pro Val 
    50                  55                  60                  


Asn Val Ala Leu Ala Leu Glu Val Ala Ser Ile Asp His Ile Ser Glu 
65                  70                  75                  80  


Ala Asn Met Glu Tyr Thr Met Thr Val Phe Leu His Gln Ser Trp Arg 
                85                  90                  95      


Asp Ser Arg Leu Ser Tyr Asn His Thr Asn Glu Thr Leu Gly Leu Asp 
            100                 105                 110         


Ser Arg Phe Val Asp Lys Leu Trp Leu Pro Asp Thr Phe Ile Val Asn 
        115                 120                 125             


Ala Lys Ser Ala Trp Phe His Asp Val Thr Val Glu Asn Lys Leu Ile 
    130                 135                 140                 


Arg Leu Gln Pro Asp Gly Val Ile Leu Tyr Ser Ile Arg Ile Thr Ser 
145                 150                 155                 160 


Thr Val Ala Cys Asp Met Asp Leu Ala Lys Tyr Pro Met Asp Glu Gln 
                165                 170                 175     


Glu Cys Met Leu Asp Leu Glu Ser Tyr Gly Tyr Ser Ser Glu Asp Ile 
            180                 185                 190         


Val Tyr Tyr Trp Ser Glu Ser Gln Glu His Ile His Gly Leu Asp Lys 
        195                 200                 205             


Leu Gln Leu Ala Gln Phe Thr Ile Thr Ser Tyr Arg Phe Thr Thr Glu 
    210                 215                 220                 


Leu Met Asn Phe Lys Ser Ala Gly Gln Phe Pro Arg Leu Ser Leu His 
225                 230                 235                 240 


Phe His Leu Arg Arg Asn Arg Gly Val Tyr Ile Ile Gln Ser Tyr Met 
                245                 250                 255     


Pro Ser Val Leu Leu Val Ala Met Ser Trp Val Ser Phe Trp Ile Ser 
            260                 265                 270         


Gln Ala Ala Val Pro Ala Arg Val Ser Leu Gly Ile Thr Thr Val Leu 
        275                 280                 285             


Thr Met Thr Thr Leu Met Val Ser Ala Arg Ser Ser Leu Pro Arg Ala 
    290                 295                 300                 


Ser Ala Ile Lys Ala Leu Asp Val Tyr Phe Trp Ile Cys Tyr Val Phe 
305                 310                 315                 320 


Val Phe Ala Ala Leu Val Glu Tyr Ala Phe Ala His Phe Asn Ala Asp 
                325                 330                 335     


Tyr Arg Lys Lys Gln Lys Ala Lys Val Lys Val Ser Arg Pro Arg Ala 
            340                 345                 350         


Glu Met Asp Val Arg Asn Ala Ile Val Leu Phe Ser Leu Ser Ala Ala 
        355                 360                 365             


Gly Val Thr Gln Glu Leu Ala Ile Ser Arg Arg Gln Arg Arg Val Pro 
    370                 375                 380                 


Gly Asn Leu Met Gly Ser Tyr Arg Ser Val Gly Val Glu Thr Gly Glu 
385                 390                 395                 400 


Thr Lys Lys Glu Gly Ala Ala Arg Ser Gly Gly Gln Gly Gly Ile Arg 
                405                 410                 415     


Ala Arg Leu Arg Pro Ile Asp Ala Asp Thr Ile Asp Ile Tyr Ala Arg 
            420                 425                 430         


Ala Val Phe Pro Ala Ala Phe Ala Ala Val Asn Val Ile Tyr Trp Ala 
        435                 440                 445             


Ala Tyr Ala Met 
    450         


<210>  272
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  272

Met Ser Ser Pro Asn Ile Trp Ser Thr Gly Ser Ser Val Tyr Ser Thr 
1               5                   10                  15      


Pro Val Phe Ser Gln Lys Met Thr Val Trp Ile Leu Leu Leu Leu Ser 
            20                  25                  30          


Leu Tyr Pro Gly Phe Thr Ser Gln Lys Ser Asp Asp Asp Tyr Glu Asp 
        35                  40                  45              


Tyr Ala Ser Asn Lys Thr Trp Val Leu Thr Pro Lys Val Pro Glu Gly 
    50                  55                  60                  


Asp Val Thr Val Ile Leu Asn Asn Leu Leu Glu Gly Tyr Asp Asn Lys 
65                  70                  75                  80  


Leu Arg Pro Asp Ile Gly Val Lys Pro Thr Leu Ile His Thr Asp Met 
                85                  90                  95      


Tyr Val Asn Ser Ile Gly Pro Val Asn Ala Ile Asn Met Glu Tyr Thr 
            100                 105                 110         


Ile Asp Ile Phe Phe Ala Gln Thr Trp Tyr Asp Arg Arg Leu Lys Phe 
        115                 120                 125             


Asn Ser Thr Ile Lys Val Leu Arg Leu Asn Ser Asn Met Val Gly Lys 
    130                 135                 140                 


Ile Trp Ile Pro Asp Thr Phe Phe Arg Asn Ser Lys Lys Ala Asp Ala 
145                 150                 155                 160 


His Trp Ile Thr Thr Pro Asn Arg Met Leu Arg Ile Trp Asn Asp Gly 
                165                 170                 175     


Arg Val Leu Tyr Thr Leu Arg Leu Thr Ile Asp Ala Glu Cys Gln Leu 
            180                 185                 190         


Gln Leu His Asn Phe Pro Met Asp Glu His Ser Cys Pro Leu Glu Phe 
        195                 200                 205             


Ser Ser Tyr Gly Tyr Pro Arg Glu Glu Ile Val Tyr Gln Trp Lys Arg 
    210                 215                 220                 


Ser Ser Val Glu Val Gly Asp Thr Arg Ser Trp Arg Leu Tyr Gln Phe 
225                 230                 235                 240 


Ser Phe Val Gly Leu Arg Asn Thr Thr Glu Val Val Lys Thr Thr Ser 
                245                 250                 255     


Gly Asp Tyr Val Val Met Ser Val Tyr Phe Asp Leu Ser Arg Arg Met 
            260                 265                 270         


Gly Tyr Phe Thr Ile Gln Thr Tyr Ile Pro Cys Thr Leu Ile Val Val 
        275                 280                 285             


Leu Ser Trp Val Ser Phe Trp Ile Asn Lys Asp Ala Val Pro Ala Arg 
    290                 295                 300                 


Thr Ser Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr Leu Ser Thr 
305                 310                 315                 320 


Ile Ala Arg Lys Ser Leu Pro Lys Val Ser Tyr Val Thr Ala Met Asp 
                325                 330                 335     


Leu Phe Val Ser Val Cys Phe Ile Phe Val Phe Ser Ala Leu Val Glu 
            340                 345                 350         


Tyr Gly Thr Leu His Tyr Phe Val Ser Asn Arg Lys Pro Ser Lys Asp 
        355                 360                 365             


Lys Asp Lys Lys Lys Lys Asn Pro Ala Pro Thr Ile Asp Ile Arg Pro 
    370                 375                 380                 


Arg Ser Ala Thr Ile Gln Met Asn Asn Ala Thr His Leu Gln Glu Arg 
385                 390                 395                 400 


Asp Glu Glu Tyr Gly Tyr Glu Cys Leu Asp Gly Lys Asp Cys Ala Ser 
                405                 410                 415     


Phe Phe Cys Cys Phe Glu Asp Cys Arg Thr Gly Ala Trp Arg His Gly 
            420                 425                 430         


Arg Ile His Ile Arg Ile Ala Lys Met Asp Ser Tyr Ala Arg Ile Phe 
        435                 440                 445             


Phe Pro Thr Ala Phe Cys Leu Phe Asn Leu Val Tyr Trp Val Ser Tyr 
    450                 455                 460                 


Leu Tyr Leu 
465         


<210>  273
<211>  758
<212>  PRT
<213>  Homo sapiens

<400>  273

Met Ala Val Ser Ala Gly Ser Ala Arg Thr Ser Pro Ser Ser Asp Lys 
1               5                   10                  15      


Val Gln Lys Asp Lys Ala Glu Leu Ile Ser Gly Pro Arg Gln Asp Ser 
            20                  25                  30          


Arg Ile Gly Lys Leu Leu Gly Phe Glu Trp Thr Asp Leu Ser Ser Trp 
        35                  40                  45              


Arg Arg Leu Val Thr Leu Leu Asn Arg Pro Thr Asp Pro Ala Ser Leu 
    50                  55                  60                  


Ala Val Phe Arg Phe Leu Phe Gly Phe Leu Met Val Leu Asp Ile Pro 
65                  70                  75                  80  


Gln Glu Arg Gly Leu Ser Ser Leu Asp Arg Lys Tyr Leu Asp Gly Leu 
                85                  90                  95      


Asp Val Cys Arg Phe Pro Leu Leu Asp Ala Leu Arg Pro Leu Pro Leu 
            100                 105                 110         


Asp Trp Met Tyr Leu Val Tyr Thr Ile Met Phe Leu Gly Ala Leu Gly 
        115                 120                 125             


Met Met Leu Gly Leu Cys Tyr Arg Ile Ser Cys Val Leu Phe Leu Leu 
    130                 135                 140                 


Pro Tyr Trp Tyr Val Phe Leu Leu Asp Lys Thr Ser Trp Asn Asn His 
145                 150                 155                 160 


Ser Tyr Leu Tyr Gly Leu Leu Ala Phe Gln Leu Thr Phe Met Asp Ala 
                165                 170                 175     


Asn His Tyr Trp Ser Val Asp Gly Leu Leu Asn Ala His Arg Arg Asn 
            180                 185                 190         


Ala His Val Pro Leu Trp Asn Tyr Ala Val Leu Arg Gly Gln Ile Phe 
        195                 200                 205             


Ile Val Tyr Phe Ile Ala Gly Val Lys Lys Leu Asp Ala Asp Trp Val 
    210                 215                 220                 


Glu Gly Tyr Ser Met Glu Tyr Leu Ser Arg His Trp Leu Phe Ser Pro 
225                 230                 235                 240 


Phe Lys Leu Leu Leu Ser Glu Glu Leu Thr Ser Leu Leu Val Val His 
                245                 250                 255     


Trp Gly Gly Leu Leu Leu Asp Leu Ser Ala Gly Phe Leu Leu Phe Phe 
            260                 265                 270         


Asp Val Ser Arg Ser Ile Gly Leu Phe Phe Val Ser Tyr Phe His Cys 
        275                 280                 285             


Met Asn Ser Gln Leu Phe Ser Ile Gly Met Phe Ser Tyr Val Met Leu 
    290                 295                 300                 


Ala Ser Ser Pro Leu Phe Cys Ser Pro Glu Trp Pro Arg Lys Leu Val 
305                 310                 315                 320 


Ser Tyr Cys Pro Arg Arg Leu Gln Gln Leu Leu Pro Leu Lys Ala Ala 
                325                 330                 335     


Pro Gln Pro Ser Val Ser Cys Val Tyr Lys Arg Ser Arg Gly Lys Ser 
            340                 345                 350         


Gly Gln Lys Pro Gly Leu Arg His Gln Leu Gly Ala Ala Phe Thr Leu 
        355                 360                 365             


Leu Tyr Leu Leu Glu Gln Leu Phe Leu Pro Tyr Ser His Phe Leu Thr 
    370                 375                 380                 


Gln Gly Tyr Asn Asn Trp Thr Asn Gly Leu Tyr Gly Tyr Ser Trp Asp 
385                 390                 395                 400 


Met Met Val His Ser Arg Ser His Gln His Val Lys Ile Thr Tyr Arg 
                405                 410                 415     


Asp Gly Arg Thr Gly Glu Leu Gly Tyr Leu Asn Pro Gly Val Phe Thr 
            420                 425                 430         


Gln Ser Arg Arg Trp Lys Asp His Ala Asp Met Leu Lys Gln Tyr Ala 
        435                 440                 445             


Thr Cys Leu Ser Arg Leu Leu Pro Lys Tyr Asn Val Thr Glu Pro Gln 
    450                 455                 460                 


Ile Tyr Phe Asp Ile Trp Val Ser Ile Asn Asp Arg Phe Gln Gln Arg 
465                 470                 475                 480 


Ile Phe Asp Pro Arg Val Asp Ile Val Gln Ala Ala Trp Ser Pro Phe 
                485                 490                 495     


Gln Arg Thr Ser Trp Val Gln Pro Leu Leu Met Asp Leu Ser Pro Trp 
            500                 505                 510         


Arg Ala Lys Leu Gln Glu Ile Lys Ser Ser Leu Asp Asn His Thr Glu 
        515                 520                 525             


Val Val Phe Ile Ala Asp Phe Pro Gly Leu His Leu Glu Asn Phe Val 
    530                 535                 540                 


Ser Glu Asp Leu Gly Asn Thr Ser Ile Gln Leu Leu Gln Gly Glu Val 
545                 550                 555                 560 


Thr Val Glu Leu Val Ala Glu Gln Lys Asn Gln Thr Leu Arg Glu Gly 
                565                 570                 575     


Glu Lys Met Gln Leu Pro Ala Gly Glu Tyr His Lys Val Tyr Thr Thr 
            580                 585                 590         


Ser Pro Ser Pro Ser Cys Tyr Met Tyr Val Tyr Val Asn Thr Thr Glu 
        595                 600                 605             


Leu Ala Leu Glu Gln Asp Leu Ala Tyr Leu Gln Glu Leu Lys Glu Lys 
    610                 615                 620                 


Val Glu Asn Gly Ser Glu Thr Gly Pro Leu Pro Pro Glu Leu Gln Pro 
625                 630                 635                 640 


Leu Leu Glu Gly Glu Val Lys Gly Gly Pro Glu Pro Thr Pro Leu Val 
                645                 650                 655     


Gln Thr Phe Leu Arg Arg Gln Gln Arg Leu Gln Glu Ile Glu Arg Arg 
            660                 665                 670         


Arg Asn Thr Pro Phe His Glu Arg Phe Phe Arg Phe Leu Leu Arg Lys 
        675                 680                 685             


Leu Tyr Val Phe Arg Arg Ser Phe Leu Met Thr Cys Ile Ser Leu Arg 
    690                 695                 700                 


Asn Leu Ile Leu Gly Arg Pro Ser Leu Glu Gln Leu Ala Gln Glu Val 
705                 710                 715                 720 


Thr Tyr Ala Asn Leu Arg Pro Phe Glu Ala Val Gly Glu Leu Asn Pro 
                725                 730                 735     


Ser Asn Thr Asp Ser Ser His Ser Asn Pro Pro Glu Ser Asn Pro Asp 
            740                 745                 750         


Pro Val His Ser Glu Phe 
        755             


<210>  274
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  274

Met Asp Arg Arg Met Trp Gly Ala His Val Phe Cys Val Leu Ser Pro 
1               5                   10                  15      


Leu Pro Thr Val Leu Gly His Met His Pro Glu Cys Asp Phe Ile Thr 
            20                  25                  30          


Gln Leu Arg Glu Asp Glu Ser Ala Cys Leu Gln Ala Ala Glu Glu Met 
        35                  40                  45              


Pro Asn Thr Thr Leu Gly Cys Pro Ala Thr Trp Asp Gly Leu Leu Cys 
    50                  55                  60                  


Trp Pro Thr Ala Gly Ser Gly Glu Trp Val Thr Leu Pro Cys Pro Asp 
65                  70                  75                  80  


Phe Phe Ser His Phe Ser Ser Glu Ser Gly Ala Val Lys Arg Asp Cys 
                85                  90                  95      


Thr Ile Thr Gly Trp Ser Glu Pro Phe Pro Pro Tyr Pro Val Ala Cys 
            100                 105                 110         


Pro Val Pro Leu Glu Leu Leu Ala Glu Glu Glu Ser Tyr Phe Ser Thr 
        115                 120                 125             


Val Lys Ile Ile Tyr Thr Val Gly His Ser Ile Ser Ile Val Ala Leu 
    130                 135                 140                 


Phe Val Ala Ile Thr Ile Leu Val Ala Leu Arg Arg Leu His Cys Pro 
145                 150                 155                 160 


Arg Asn Tyr Val His Thr Gln Leu Phe Thr Thr Phe Ile Leu Lys Ala 
                165                 170                 175     


Gly Ala Val Phe Leu Lys Asp Ala Ala Leu Phe His Ser Asp Asp Thr 
            180                 185                 190         


Asp His Cys Ser Phe Ser Thr Val Leu Cys Lys Val Ser Val Ala Ala 
        195                 200                 205             


Ser His Phe Ala Thr Met Thr Asn Phe Ser Trp Leu Leu Ala Glu Ala 
    210                 215                 220                 


Val Tyr Leu Asn Cys Leu Leu Ala Ser Thr Ser Pro Ser Ser Arg Arg 
225                 230                 235                 240 


Ala Phe Trp Trp Leu Val Leu Ala Gly Trp Gly Leu Pro Val Leu Phe 
                245                 250                 255     


Thr Gly Thr Trp Val Ser Cys Lys Leu Ala Phe Glu Asp Ile Ala Cys 
            260                 265                 270         


Trp Asp Leu Asp Asp Thr Ser Pro Tyr Trp Trp Ile Ile Lys Gly Pro 
        275                 280                 285             


Ile Val Leu Ser Val Gly Val Asn Phe Gly Leu Phe Leu Asn Ile Ile 
    290                 295                 300                 


Arg Ile Leu Val Arg Lys Leu Glu Pro Ala Gln Gly Ser Leu His Thr 
305                 310                 315                 320 


Gln Ser Gln Tyr Trp Arg Leu Ser Lys Ser Thr Leu Phe Leu Ile Pro 
                325                 330                 335     


Leu Phe Gly Ile His Tyr Ile Ile Phe Asn Phe Leu Pro Asp Asn Ala 
            340                 345                 350         


Gly Leu Gly Ile Arg Leu Pro Leu Glu Leu Gly Leu Gly Ser Phe Gln 
        355                 360                 365             


Gly Phe Ile Val Ala Ile Leu Tyr Cys Phe Leu Asn Gln Glu Val Arg 
    370                 375                 380                 


Thr Glu Ile Ser Arg Lys Trp His Gly His Asp Pro Glu Leu Leu Pro 
385                 390                 395                 400 


Ala Trp Arg Thr Arg Ala Lys Trp Thr Thr Pro Ser Arg Ser Ala Ala 
                405                 410                 415     


Lys Val Leu Thr Ser Met Cys 
            420             


<210>  275
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  275

Met Lys Phe Leu Leu Thr Thr Ala Phe Leu Ile Leu Ile Ser Leu Trp 
1               5                   10                  15      


Val Glu Glu Ala Tyr Ser Lys Glu Lys Ser Ser Lys Lys Gly Lys Gly 
            20                  25                  30          


Lys Lys Lys Gln Tyr Leu Cys Pro Ser Gln Gln Ser Ala Glu Asp Leu 
        35                  40                  45              


Ala Arg Val Pro Ala Asn Ser Thr Ser Asn Ile Leu Asn Arg Leu Leu 
    50                  55                  60                  


Val Ser Tyr Asp Pro Arg Ile Arg Pro Asn Phe Lys Gly Ile Pro Val 
65                  70                  75                  80  


Asp Val Val Val Asn Ile Phe Ile Asn Ser Phe Gly Ser Ile Gln Glu 
                85                  90                  95      


Thr Thr Met Asp Tyr Arg Val Asn Ile Phe Leu Arg Gln Lys Trp Asn 
            100                 105                 110         


Asp Pro Arg Leu Lys Leu Pro Ser Asp Phe Arg Gly Ser Asp Ala Leu 
        115                 120                 125             


Thr Val Asp Pro Thr Met Tyr Lys Cys Leu Trp Lys Pro Asp Leu Phe 
    130                 135                 140                 


Phe Ala Asn Glu Lys Ser Ala Asn Phe His Asp Val Thr Gln Glu Asn 
145                 150                 155                 160 


Ile Leu Leu Phe Ile Phe Arg Asp Gly Asp Val Leu Val Ser Met Arg 
                165                 170                 175     


Leu Ser Ile Thr Leu Ser Cys Pro Leu Asp Leu Thr Leu Phe Pro Met 
            180                 185                 190         


Asp Thr Gln Arg Cys Lys Met Gln Leu Glu Ser Phe Gly Tyr Thr Thr 
        195                 200                 205             


Asp Asp Leu Arg Phe Ile Trp Gln Ser Gly Asp Pro Val Gln Leu Glu 
    210                 215                 220                 


Lys Ile Ala Leu Pro Gln Phe Asp Ile Lys Lys Glu Asp Ile Glu Tyr 
225                 230                 235                 240 


Gly Asn Cys Thr Lys Tyr Tyr Lys Gly Thr Gly Tyr Tyr Thr Cys Val 
                245                 250                 255     


Glu Val Ile Phe Thr Leu Arg Arg Gln Val Gly Phe Tyr Met Met Gly 
            260                 265                 270         


Val Tyr Ala Pro Thr Leu Leu Ile Val Val Leu Ser Trp Leu Ser Phe 
        275                 280                 285             


Trp Ile Asn Pro Asp Ala Ser Ala Ala Arg Val Pro Leu Gly Ile Phe 
    290                 295                 300                 


Ser Val Leu Ser Leu Ala Ser Glu Cys Thr Thr Leu Ala Ala Glu Leu 
305                 310                 315                 320 


Pro Lys Val Ser Tyr Val Lys Ala Leu Asp Val Trp Leu Ile Ala Cys 
                325                 330                 335     


Leu Leu Phe Gly Phe Ala Ser Leu Val Glu Tyr Ala Val Val Gln Val 
            340                 345                 350         


Met Leu Asn Asn Pro Lys Arg Val Glu Ala Glu Lys Ala Arg Ile Ala 
        355                 360                 365             


Lys Ala Glu Gln Ala Asp Gly Lys Gly Gly Asn Val Ala Lys Lys Asn 
    370                 375                 380                 


Thr Val Asn Gly Thr Gly Thr Pro Val His Ile Ser Thr Leu Gln Val 
385                 390                 395                 400 


Gly Glu Thr Arg Cys Lys Lys Val Cys Thr Ser Lys Ser Asp Leu Arg 
                405                 410                 415     


Ser Asn Asp Phe Ser Ile Val Gly Ser Leu Pro Arg Asp Phe Glu Leu 
            420                 425                 430         


Ser Asn Tyr Asp Cys Tyr Gly Lys Pro Ile Glu Val Asn Asn Gly Leu 
        435                 440                 445             


Gly Lys Ser Gln Ala Lys Asn Asn Lys Lys Pro Pro Pro Ala Lys Pro 
    450                 455                 460                 


Val Ile Pro Thr Ala Ala Lys Arg Ile Asp Leu Tyr Ala Arg Ala Leu 
465                 470                 475                 480 


Phe Pro Phe Cys Phe Leu Phe Phe Asn Val Ile Tyr Trp Ser Ile Tyr 
                485                 490                 495     


Leu 
    


<210>  276
<211>  883
<212>  PRT
<213>  Homo sapiens

<400>  276

Met Gln Lys Ile Met His Ile Ser Val Leu Leu Ser Pro Val Leu Trp 
1               5                   10                  15      


Gly Leu Ile Phe Gly Val Ser Ser Asn Ser Ile Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Pro Arg Gly Ala Asp Gln Glu Tyr Ser Ala Phe Arg Val Gly Met 
        35                  40                  45              


Val Gln Phe Ser Thr Ser Glu Phe Arg Leu Thr Pro His Ile Asp Asn 
    50                  55                  60                  


Leu Glu Val Ala Asn Ser Phe Ala Val Thr Asn Ala Phe Cys Ser Gln 
65                  70                  75                  80  


Phe Ser Arg Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Lys Lys Ser 
                85                  90                  95      


Val Asn Thr Ile Thr Ser Phe Cys Gly Thr Leu His Val Ser Phe Ile 
            100                 105                 110         


Thr Pro Ser Phe Pro Thr Asp Gly Thr His Pro Phe Val Ile Gln Met 
        115                 120                 125             


Arg Pro Asp Leu Lys Gly Ala Leu Leu Ser Leu Ile Glu Tyr Tyr Gln 
    130                 135                 140                 


Trp Asp Lys Phe Ala Tyr Leu Tyr Asp Ser Asp Arg Gly Leu Ser Thr 
145                 150                 155                 160 


Leu Gln Ala Val Leu Asp Ser Ala Ala Glu Lys Lys Trp Gln Val Thr 
                165                 170                 175     


Ala Ile Asn Val Gly Asn Ile Asn Asn Asp Lys Lys Asp Glu Met Tyr 
            180                 185                 190         


Arg Ser Leu Phe Gln Asp Leu Glu Leu Lys Lys Glu Arg Arg Val Ile 
        195                 200                 205             


Leu Asp Cys Glu Arg Asp Lys Val Asn Asp Ile Val Asp Gln Val Ile 
    210                 215                 220                 


Thr Ile Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala Asn Leu 
225                 230                 235                 240 


Gly Phe Thr Asp Gly Asp Leu Leu Lys Ile Gln Phe Gly Gly Ala Asn 
                245                 250                 255     


Val Ser Gly Phe Gln Ile Val Asp Tyr Asp Asp Ser Leu Val Ser Lys 
            260                 265                 270         


Phe Ile Glu Arg Trp Ser Thr Leu Glu Glu Lys Glu Tyr Pro Gly Ala 
        275                 280                 285             


His Thr Thr Thr Ile Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Ala Val 
    290                 295                 300                 


Gln Val Met Thr Glu Ala Phe Arg Asn Leu Arg Lys Gln Arg Ile Glu 
305                 310                 315                 320 


Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala Val 
                325                 330                 335     


Pro Trp Gly Gln Gly Val Glu Ile Glu Arg Ala Leu Lys Gln Val Gln 
            340                 345                 350         


Val Glu Gly Leu Ser Gly Asn Ile Lys Phe Asp Gln Asn Gly Lys Arg 
        355                 360                 365             


Ile Asn Tyr Thr Ile Asn Ile Met Glu Leu Lys Thr Asn Gly Pro Arg 
    370                 375                 380                 


Lys Ile Gly Tyr Trp Ser Glu Val Asp Lys Met Val Val Thr Leu Thr 
385                 390                 395                 400 


Glu Leu Pro Ser Gly Asn Asp Thr Ser Gly Leu Glu Asn Lys Thr Val 
                405                 410                 415     


Val Val Thr Thr Ile Leu Glu Ser Pro Tyr Val Met Met Lys Lys Asn 
            420                 425                 430         


His Glu Met Leu Glu Gly Asn Glu Arg Tyr Glu Gly Tyr Cys Val Asp 
        435                 440                 445             


Leu Ala Ala Glu Ile Ala Lys His Cys Gly Phe Lys Tyr Lys Leu Thr 
    450                 455                 460                 


Ile Val Gly Asp Gly Lys Tyr Gly Ala Arg Asp Ala Asp Thr Lys Ile 
465                 470                 475                 480 


Trp Asn Gly Met Val Gly Glu Leu Val Tyr Gly Lys Ala Asp Ile Ala 
                485                 490                 495     


Ile Ala Pro Leu Thr Ile Thr Leu Val Arg Glu Glu Val Ile Asp Phe 
            500                 505                 510         


Ser Lys Pro Phe Met Ser Leu Gly Ile Ser Ile Met Ile Lys Lys Pro 
        515                 520                 525             


Gln Lys Ser Lys Pro Gly Val Phe Ser Phe Leu Asp Pro Leu Ala Tyr 
    530                 535                 540                 


Glu Ile Trp Met Cys Ile Val Phe Ala Tyr Ile Gly Val Ser Val Val 
545                 550                 555                 560 


Leu Phe Leu Val Ser Arg Phe Ser Pro Tyr Glu Trp His Thr Glu Glu 
                565                 570                 575     


Phe Glu Asp Gly Arg Glu Thr Gln Ser Ser Glu Ser Thr Asn Glu Phe 
            580                 585                 590         


Gly Ile Phe Asn Ser Leu Trp Phe Ser Leu Gly Ala Phe Met Arg Gln 
        595                 600                 605             


Gly Cys Asp Ile Ser Pro Arg Ser Leu Ser Gly Arg Ile Val Gly Gly 
    610                 615                 620                 


Val Trp Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn 
625                 630                 635                 640 


Leu Ala Ala Phe Leu Thr Val Glu Arg Met Val Ser Pro Ile Glu Ser 
                645                 650                 655     


Ala Glu Asp Leu Ser Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu Asp 
            660                 665                 670         


Ser Gly Ser Thr Lys Glu Phe Phe Arg Arg Ser Lys Ile Ala Val Phe 
        675                 680                 685             


Asp Lys Met Trp Thr Tyr Met Arg Ser Ala Glu Pro Ser Val Phe Val 
    690                 695                 700                 


Arg Thr Thr Ala Glu Gly Val Ala Arg Val Arg Lys Ser Lys Gly Lys 
705                 710                 715                 720 


Tyr Ala Tyr Leu Leu Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln Arg 
                725                 730                 735     


Lys Pro Cys Asp Thr Met Lys Val Gly Gly Asn Leu Asp Ser Lys Gly 
            740                 745                 750         


Tyr Gly Ile Ala Thr Pro Lys Gly Ser Ser Leu Arg Thr Pro Val Asn 
        755                 760                 765             


Leu Ala Val Leu Lys Leu Ser Glu Gln Gly Val Leu Asp Lys Leu Lys 
    770                 775                 780                 


Asn Lys Trp Trp Tyr Asp Lys Gly Glu Cys Gly Ala Lys Asp Ser Gly 
785                 790                 795                 800 


Ser Lys Glu Lys Thr Ser Ala Leu Ser Leu Ser Asn Val Ala Gly Val 
                805                 810                 815     


Phe Tyr Ile Leu Val Gly Gly Leu Gly Leu Ala Met Leu Val Ala Leu 
            820                 825                 830         


Ile Glu Phe Cys Tyr Lys Ser Arg Ala Glu Ala Lys Arg Met Lys Val 
        835                 840                 845             


Ala Lys Asn Ala Gln Asn Ile Asn Pro Ser Ser Ser Gln Asn Ser Gln 
    850                 855                 860                 


Asn Phe Ala Thr Tyr Lys Glu Gly Tyr Asn Val Tyr Gly Ile Glu Ser 
865                 870                 875                 880 


Val Lys Ile 
            


<210>  277
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  277

Met Gln His Ile Phe Ala Phe Phe Cys Thr Gly Phe Leu Gly Ala Val 
1               5                   10                  15      


Val Gly Ala Asn Phe Pro Asn Asn Ile Gln Ile Gly Gly Leu Phe Pro 
            20                  25                  30          


Asn Gln Gln Ser Gln Glu His Ala Ala Phe Arg Phe Ala Leu Ser Gln 
        35                  40                  45              


Leu Thr Glu Pro Pro Lys Leu Leu Pro Gln Ile Asp Ile Val Asn Ile 
    50                  55                  60                  


Ser Asp Ser Phe Glu Met Thr Tyr Arg Phe Cys Ser Gln Phe Ser Lys 
65                  70                  75                  80  


Gly Val Tyr Ala Ile Phe Gly Phe Tyr Glu Arg Arg Thr Val Asn Met 
                85                  90                  95      


Leu Thr Ser Phe Cys Gly Ala Leu His Val Cys Phe Ile Thr Pro Ser 
            100                 105                 110         


Phe Pro Val Asp Thr Ser Asn Gln Phe Val Leu Gln Leu Arg Pro Glu 
        115                 120                 125             


Leu Gln Asp Ala Leu Ile Ser Ile Ile Asp His Tyr Lys Trp Gln Lys 
    130                 135                 140                 


Phe Val Tyr Ile Tyr Asp Ala Asp Arg Gly Leu Ser Val Leu Gln Lys 
145                 150                 155                 160 


Val Leu Asp Thr Ala Ala Glu Lys Asn Trp Gln Val Thr Ala Val Asn 
                165                 170                 175     


Ile Leu Thr Thr Thr Glu Glu Gly Tyr Arg Met Leu Phe Gln Asp Leu 
            180                 185                 190         


Glu Lys Lys Lys Glu Arg Leu Val Val Val Asp Cys Glu Ser Glu Arg 
        195                 200                 205             


Leu Asn Ala Ile Leu Gly Gln Ile Ile Lys Leu Glu Lys Asn Gly Ile 
    210                 215                 220                 


Gly Tyr His Tyr Ile Leu Ala Asn Leu Gly Phe Met Asp Ile Asp Leu 
225                 230                 235                 240 


Asn Lys Phe Lys Glu Ser Gly Ala Asn Val Thr Gly Phe Gln Leu Val 
                245                 250                 255     


Asn Tyr Thr Asp Thr Ile Pro Ala Lys Ile Met Gln Gln Trp Lys Asn 
            260                 265                 270         


Ser Asp Ala Arg Asp His Thr Arg Val Asp Trp Lys Arg Pro Lys Tyr 
        275                 280                 285             


Thr Ser Ala Leu Thr Tyr Asp Gly Val Lys Val Met Ala Glu Ala Phe 
    290                 295                 300                 


Gln Ser Leu Arg Arg Gln Arg Ile Asp Ile Ser Arg Arg Gly Asn Ala 
305                 310                 315                 320 


Gly Asp Cys Leu Ala Asn Pro Ala Val Pro Trp Gly Gln Gly Ile Asp 
                325                 330                 335     


Ile Gln Arg Ala Leu Gln Gln Val Arg Phe Glu Gly Leu Thr Gly Asn 
            340                 345                 350         


Val Gln Phe Asn Glu Lys Gly Arg Arg Thr Asn Tyr Thr Leu His Val 
        355                 360                 365             


Ile Glu Met Lys His Asp Gly Ile Arg Lys Ile Gly Tyr Trp Asn Glu 
    370                 375                 380                 


Asp Asp Lys Phe Val Pro Ala Ala Thr Asp Ala Gln Ala Gly Gly Asp 
385                 390                 395                 400 


Asn Ser Ser Val Gln Asn Arg Thr Tyr Ile Val Thr Thr Ile Leu Glu 
                405                 410                 415     


Asp Pro Tyr Val Met Leu Lys Lys Asn Ala Asn Gln Phe Glu Gly Asn 
            420                 425                 430         


Asp Arg Tyr Glu Gly Tyr Cys Val Glu Leu Ala Ala Glu Ile Ala Lys 
        435                 440                 445             


His Val Gly Tyr Ser Tyr Arg Leu Glu Ile Val Ser Asp Gly Lys Tyr 
    450                 455                 460                 


Gly Ala Arg Asp Pro Asp Thr Lys Ala Trp Asn Gly Met Val Gly Glu 
465                 470                 475                 480 


Leu Val Tyr Gly Arg Ala Asp Val Ala Val Ala Pro Leu Thr Ile Thr 
                485                 490                 495     


Leu Val Arg Glu Glu Val Ile Asp Phe Ser Lys Pro Phe Met Ser Leu 
            500                 505                 510         


Gly Ile Ser Ile Met Ile Lys Lys Pro Gln Lys Ser Lys Pro Gly Val 
        515                 520                 525             


Phe Ser Phe Leu Asp Pro Leu Ala Tyr Glu Ile Trp Met Cys Ile Val 
    530                 535                 540                 


Phe Ala Tyr Ile Gly Val Ser Val Val Leu Phe Leu Val Ser Arg Phe 
545                 550                 555                 560 


Ser Pro Tyr Glu Trp His Ser Glu Glu Phe Glu Glu Gly Arg Asp Gln 
                565                 570                 575     


Thr Thr Ser Asp Gln Ser Asn Glu Phe Gly Ile Phe Asn Ser Leu Trp 
            580                 585                 590         


Phe Ser Leu Gly Ala Phe Met Gln Gln Gly Cys Asp Ile Ser Pro Arg 
        595                 600                 605             


Ser Leu Ser Gly Arg Ile Val Gly Gly Val Trp Trp Phe Phe Thr Leu 
    610                 615                 620                 


Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu Thr Val 
625                 630                 635                 640 


Glu Arg Met Val Ser Pro Ile Glu Ser Ala Glu Asp Leu Ala Lys Gln 
                645                 650                 655     


Thr Glu Ile Ala Tyr Gly Thr Leu Glu Ala Gly Ser Thr Lys Glu Phe 
            660                 665                 670         


Phe Arg Arg Ser Lys Ile Ala Val Phe Glu Lys Met Trp Thr Tyr Met 
        675                 680                 685             


Lys Ser Ala Glu Pro Ser Val Phe Val Arg Thr Thr Glu Glu Gly Met 
    690                 695                 700                 


Ile Arg Val Arg Lys Ser Lys Gly Lys Tyr Ala Tyr Leu Leu Glu Ser 
705                 710                 715                 720 


Thr Met Asn Glu Tyr Ile Glu Gln Arg Lys Pro Cys Asp Thr Met Lys 
                725                 730                 735     


Val Gly Gly Asn Leu Asp Ser Lys Gly Tyr Gly Ile Ala Thr Pro Lys 
            740                 745                 750         


Gly Ser Ala Leu Arg Asn Pro Val Asn Leu Ala Val Leu Lys Leu Asn 
        755                 760                 765             


Glu Gln Gly Leu Leu Asp Lys Leu Lys Asn Lys Trp Trp Tyr Asp Lys 
    770                 775                 780                 


Gly Glu Cys Gly Ser Gly Gly Gly Asp Ser Lys Asp Lys Thr Ser Ala 
785                 790                 795                 800 


Leu Ser Leu Ser Asn Val Ala Gly Val Phe Tyr Ile Leu Ile Gly Gly 
                805                 810                 815     


Leu Gly Leu Ala Met Leu Val Ala Leu Ile Glu Phe Cys Tyr Lys Ser 
            820                 825                 830         


Arg Ser Glu Ser Lys Arg Met Lys Gly Phe Cys Leu Ile Pro Gln Gln 
        835                 840                 845             


Ser Ile Asn Glu Ala Ile Arg Thr Ser Thr Leu Pro Arg Asn Ser Gly 
    850                 855                 860                 


Ala Gly Ala Ser Ser Gly Gly Ser Gly Glu Asn Gly Arg Val Val Ser 
865                 870                 875                 880 


His Asp Phe Pro Lys Ser Met Gln Ser Ile Pro Cys Met Ser His Ser 
                885                 890                 895     


Ser Gly Met Pro Leu Gly Ala Thr Gly Leu 
            900                 905     


<210>  278
<211>  894
<212>  PRT
<213>  Homo sapiens

<400>  278

Met Ala Arg Gln Lys Lys Met Gly Gln Ser Val Leu Arg Ala Val Phe 
1               5                   10                  15      


Phe Leu Val Leu Gly Leu Leu Gly His Ser His Gly Gly Phe Pro Asn 
            20                  25                  30          


Thr Ile Ser Ile Gly Gly Leu Phe Met Arg Asn Thr Val Gln Glu His 
        35                  40                  45              


Ser Ala Phe Arg Phe Ala Val Gln Leu Tyr Asn Thr Asn Gln Asn Thr 
    50                  55                  60                  


Thr Glu Lys Pro Phe His Leu Asn Tyr His Val Asp His Leu Asp Ser 
65                  70                  75                  80  


Ser Asn Ser Phe Ser Val Thr Asn Ala Phe Cys Ser Gln Phe Ser Arg 
                85                  90                  95      


Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Gln Met Ser Met Asn Thr 
            100                 105                 110         


Leu Thr Ser Phe Cys Gly Ala Leu His Thr Ser Phe Val Thr Pro Ser 
        115                 120                 125             


Phe Pro Thr Asp Ala Asp Val Gln Phe Val Ile Gln Met Arg Pro Ala 
    130                 135                 140                 


Leu Lys Gly Ala Ile Leu Ser Leu Leu Gly His Tyr Lys Trp Glu Lys 
145                 150                 155                 160 


Phe Val Tyr Leu Tyr Asp Thr Glu Arg Gly Phe Ser Ile Leu Gln Ala 
                165                 170                 175     


Ile Met Glu Ala Ala Val Gln Asn Asn Trp Gln Val Thr Ala Arg Ser 
            180                 185                 190         


Val Gly Asn Ile Lys Asp Val Gln Glu Phe Arg Arg Ile Ile Glu Glu 
        195                 200                 205             


Met Asp Arg Arg Gln Glu Lys Arg Tyr Leu Ile Asp Cys Glu Val Glu 
    210                 215                 220                 


Arg Ile Asn Thr Ile Leu Glu Gln Val Val Ile Leu Gly Lys His Ser 
225                 230                 235                 240 


Arg Gly Tyr His Tyr Met Leu Ala Asn Leu Gly Phe Thr Asp Ile Leu 
                245                 250                 255     


Leu Glu Arg Val Met His Gly Gly Ala Asn Ile Thr Gly Phe Gln Ile 
            260                 265                 270         


Val Asn Asn Glu Asn Pro Met Val Gln Gln Phe Ile Gln Arg Trp Val 
        275                 280                 285             


Arg Leu Asp Glu Arg Glu Phe Pro Glu Ala Lys Asn Ala Pro Leu Lys 
    290                 295                 300                 


Tyr Thr Ser Ala Leu Thr His Asp Ala Ile Leu Val Ile Ala Glu Ala 
305                 310                 315                 320 


Phe Arg Tyr Leu Arg Arg Gln Arg Val Asp Val Ser Arg Arg Gly Ser 
                325                 330                 335     


Ala Gly Asp Cys Leu Ala Asn Pro Ala Val Pro Trp Ser Gln Gly Ile 
            340                 345                 350         


Asp Ile Glu Arg Ala Leu Lys Met Val Gln Val Gln Gly Met Thr Gly 
        355                 360                 365             


Asn Ile Gln Phe Asp Thr Tyr Gly Arg Arg Thr Asn Tyr Thr Ile Asp 
    370                 375                 380                 


Val Tyr Glu Met Lys Val Ser Gly Ser Arg Lys Ala Gly Tyr Trp Asn 
385                 390                 395                 400 


Glu Tyr Glu Arg Phe Val Pro Phe Ser Asp Gln Gln Ile Ser Asn Asp 
                405                 410                 415     


Ser Ala Ser Ser Glu Asn Arg Thr Ile Val Val Thr Thr Ile Leu Glu 
            420                 425                 430         


Ser Pro Tyr Val Met Tyr Lys Lys Asn His Glu Gln Leu Glu Gly Asn 
        435                 440                 445             


Glu Arg Tyr Glu Gly Tyr Cys Val Asp Leu Ala Tyr Glu Ile Ala Lys 
    450                 455                 460                 


His Val Arg Ile Lys Tyr Lys Leu Ser Ile Val Gly Asp Gly Lys Tyr 
465                 470                 475                 480 


Gly Ala Arg Asp Pro Glu Thr Lys Ile Trp Asn Gly Met Val Gly Glu 
                485                 490                 495     


Leu Val Tyr Gly Arg Ala Asp Ile Ala Val Ala Pro Leu Thr Ile Thr 
            500                 505                 510         


Leu Val Arg Glu Glu Val Ile Asp Phe Ser Lys Pro Phe Met Ser Leu 
        515                 520                 525             


Gly Ile Ser Ile Met Ile Lys Lys Pro Gln Lys Ser Lys Pro Gly Val 
    530                 535                 540                 


Phe Ser Phe Leu Asp Pro Leu Ala Tyr Glu Ile Trp Met Cys Ile Val 
545                 550                 555                 560 


Phe Ala Tyr Ile Gly Val Ser Val Val Leu Phe Leu Val Ser Arg Phe 
                565                 570                 575     


Ser Pro Tyr Glu Trp His Leu Glu Asp Asn Asn Glu Glu Pro Arg Asp 
            580                 585                 590         


Pro Gln Ser Pro Pro Asp Pro Pro Asn Glu Phe Gly Ile Phe Asn Ser 
        595                 600                 605             


Leu Trp Phe Ser Leu Gly Ala Phe Met Gln Gln Gly Cys Asp Ile Ser 
    610                 615                 620                 


Pro Arg Ser Leu Ser Gly Arg Ile Val Gly Gly Val Trp Trp Phe Phe 
625                 630                 635                 640 


Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu 
                645                 650                 655     


Thr Val Glu Arg Met Val Ser Pro Ile Glu Ser Ala Glu Asp Leu Ala 
            660                 665                 670         


Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu Asp Ser Gly Ser Thr Lys 
        675                 680                 685             


Glu Phe Phe Arg Arg Ser Lys Ile Ala Val Tyr Glu Lys Met Trp Ser 
    690                 695                 700                 


Tyr Met Lys Ser Ala Glu Pro Ser Val Phe Thr Lys Thr Thr Ala Asp 
705                 710                 715                 720 


Gly Val Ala Arg Val Arg Lys Ser Lys Gly Lys Phe Ala Phe Leu Leu 
                725                 730                 735     


Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln Arg Lys Pro Cys Asp Thr 
            740                 745                 750         


Met Lys Val Gly Gly Asn Leu Asp Ser Lys Gly Tyr Gly Val Ala Thr 
        755                 760                 765             


Pro Lys Gly Ser Ala Leu Gly Asn Ala Val Asn Leu Ala Val Leu Lys 
    770                 775                 780                 


Leu Asn Glu Gln Gly Leu Leu Asp Lys Leu Lys Asn Lys Trp Trp Tyr 
785                 790                 795                 800 


Asp Lys Gly Glu Cys Gly Ser Gly Gly Gly Asp Ser Lys Asp Lys Thr 
                805                 810                 815     


Ser Ala Leu Ser Leu Ser Asn Val Ala Gly Val Phe Tyr Ile Leu Val 
            820                 825                 830         


Gly Gly Leu Gly Leu Ala Met Met Val Ala Leu Ile Glu Phe Cys Tyr 
        835                 840                 845             


Lys Ser Arg Ala Glu Ser Lys Arg Met Lys Leu Thr Lys Asn Thr Gln 
    850                 855                 860                 


Asn Phe Lys Pro Ala Pro Ala Thr Asn Thr Gln Asn Tyr Ala Thr Tyr 
865                 870                 875                 880 


Arg Glu Gly Tyr Asn Val Tyr Gly Thr Glu Ser Val Lys Ile 
                885                 890                 


<210>  279
<211>  902
<212>  PRT
<213>  Homo sapiens

<400>  279

Met Arg Ile Ile Ser Arg Gln Ile Val Leu Leu Phe Ser Gly Phe Trp 
1               5                   10                  15      


Gly Leu Ala Met Gly Ala Phe Pro Ser Ser Val Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Ile Arg Asn Thr Asp Gln Glu Tyr Thr Ala Phe Arg Leu Ala Ile 
        35                  40                  45              


Phe Leu His Asn Thr Ser Pro Asn Ala Ser Glu Ala Pro Phe Asn Leu 
    50                  55                  60                  


Val Pro His Val Asp Asn Ile Glu Thr Ala Asn Ser Phe Ala Val Thr 
65                  70                  75                  80  


Asn Ala Phe Cys Ser Gln Tyr Ser Arg Gly Val Phe Ala Ile Phe Gly 
                85                  90                  95      


Leu Tyr Asp Lys Arg Ser Val His Thr Leu Thr Ser Phe Cys Ser Ala 
            100                 105                 110         


Leu His Ile Ser Leu Ile Thr Pro Ser Phe Pro Thr Glu Gly Glu Ser 
        115                 120                 125             


Gln Phe Val Leu Gln Leu Arg Pro Ser Leu Arg Gly Ala Leu Leu Ser 
    130                 135                 140                 


Leu Leu Asp His Tyr Glu Trp Asn Cys Phe Val Phe Leu Tyr Asp Thr 
145                 150                 155                 160 


Asp Arg Gly Tyr Ser Ile Leu Gln Ala Ile Met Glu Lys Ala Gly Gln 
                165                 170                 175     


Asn Gly Trp His Val Ser Ala Ile Cys Val Glu Asn Phe Asn Asp Val 
            180                 185                 190         


Ser Tyr Arg Gln Leu Leu Glu Glu Leu Asp Arg Arg Gln Glu Lys Lys 
        195                 200                 205             


Phe Val Ile Asp Cys Glu Ile Glu Arg Leu Gln Asn Ile Leu Glu Gln 
    210                 215                 220                 


Ile Val Ser Val Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala 
225                 230                 235                 240 


Asn Leu Gly Phe Lys Asp Ile Ser Leu Glu Arg Phe Ile His Gly Gly 
                245                 250                 255     


Ala Asn Val Thr Gly Phe Gln Leu Val Asp Phe Asn Thr Pro Met Val 
            260                 265                 270         


Ile Lys Leu Met Asp Arg Trp Lys Lys Leu Asp Gln Arg Glu Tyr Pro 
        275                 280                 285             


Gly Ser Glu Thr Pro Pro Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Gly 
    290                 295                 300                 


Val Leu Val Met Ala Glu Thr Phe Arg Ser Leu Arg Arg Gln Lys Ile 
305                 310                 315                 320 


Asp Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala 
                325                 330                 335     


Ala Pro Trp Gly Gln Gly Ile Asp Met Glu Arg Thr Leu Lys Gln Val 
            340                 345                 350         


Arg Ile Gln Gly Leu Thr Gly Asn Val Gln Phe Asp His Tyr Gly Arg 
        355                 360                 365             


Arg Val Asn Tyr Thr Met Asp Val Phe Glu Leu Lys Ser Thr Gly Pro 
    370                 375                 380                 


Arg Lys Val Gly Tyr Trp Asn Asp Met Asp Lys Leu Val Leu Ile Gln 
385                 390                 395                 400 


Asp Val Pro Thr Leu Gly Asn Asp Thr Ala Ala Ile Glu Asn Arg Thr 
                405                 410                 415     


Val Val Val Thr Thr Ile Met Glu Ser Pro Tyr Val Met Tyr Lys Lys 
            420                 425                 430         


Asn His Glu Met Phe Glu Gly Asn Asp Lys Tyr Glu Gly Tyr Cys Val 
        435                 440                 445             


Asp Leu Ala Ser Glu Ile Ala Lys His Ile Gly Ile Lys Tyr Lys Ile 
    450                 455                 460                 


Ala Ile Val Pro Asp Gly Lys Tyr Gly Ala Arg Asp Ala Asp Thr Lys 
465                 470                 475                 480 


Ile Trp Asn Gly Met Val Gly Glu Leu Val Tyr Gly Lys Ala Glu Ile 
                485                 490                 495     


Ala Ile Ala Pro Leu Thr Ile Thr Leu Val Arg Glu Glu Val Ile Asp 
            500                 505                 510         


Phe Ser Lys Pro Phe Met Ser Leu Gly Ile Ser Ile Met Ile Lys Lys 
        515                 520                 525             


Pro Gln Lys Ser Lys Pro Gly Val Phe Ser Phe Leu Asp Pro Leu Ala 
    530                 535                 540                 


Tyr Glu Ile Trp Met Cys Ile Val Phe Ala Tyr Ile Gly Val Ser Val 
545                 550                 555                 560 


Val Leu Phe Leu Val Ser Arg Phe Ser Pro Tyr Glu Trp His Thr Glu 
                565                 570                 575     


Glu Pro Glu Asp Gly Lys Glu Gly Pro Ser Asp Gln Pro Pro Asn Glu 
            580                 585                 590         


Phe Gly Ile Phe Asn Ser Leu Trp Phe Ser Leu Gly Ala Phe Met Gln 
        595                 600                 605             


Gln Gly Cys Asp Ile Ser Pro Arg Ser Leu Ser Gly Arg Ile Val Gly 
    610                 615                 620                 


Gly Val Trp Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala 
625                 630                 635                 640 


Asn Leu Ala Ala Phe Leu Thr Val Glu Arg Met Val Ser Pro Ile Glu 
                645                 650                 655     


Ser Ala Glu Asp Leu Ala Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu 
            660                 665                 670         


Asp Ser Gly Ser Thr Lys Glu Phe Phe Arg Arg Ser Lys Ile Ala Val 
        675                 680                 685             


Tyr Glu Lys Met Trp Thr Tyr Met Arg Ser Ala Glu Pro Ser Val Phe 
    690                 695                 700                 


Thr Arg Thr Thr Ala Glu Gly Val Ala Arg Val Arg Lys Ser Lys Gly 
705                 710                 715                 720 


Lys Phe Ala Phe Leu Leu Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln 
                725                 730                 735     


Arg Lys Pro Cys Asp Thr Met Lys Val Gly Gly Asn Leu Asp Ser Lys 
            740                 745                 750         


Gly Tyr Gly Val Ala Thr Pro Lys Gly Ser Ser Leu Gly Thr Pro Val 
        755                 760                 765             


Asn Leu Ala Val Leu Lys Leu Ser Glu Ala Gly Val Leu Asp Lys Leu 
    770                 775                 780                 


Lys Asn Lys Trp Trp Tyr Asp Lys Gly Glu Cys Gly Pro Lys Asp Ser 
785                 790                 795                 800 


Gly Ser Lys Asp Lys Thr Ser Ala Leu Ser Leu Ser Asn Val Ala Gly 
                805                 810                 815     


Val Phe Tyr Ile Leu Val Gly Gly Leu Gly Leu Ala Met Leu Val Ala 
            820                 825                 830         


Leu Ile Glu Phe Cys Tyr Lys Ser Arg Ala Glu Ala Lys Arg Met Lys 
        835                 840                 845             


Leu Thr Phe Ser Glu Ala Ile Arg Asn Lys Ala Arg Leu Ser Ile Thr 
    850                 855                 860                 


Gly Ser Val Gly Glu Asn Gly Arg Val Leu Thr Pro Asp Cys Pro Lys 
865                 870                 875                 880 


Ala Val His Thr Gly Thr Ala Ile Arg Gln Ser Ser Gly Leu Ala Val 
                885                 890                 895     


Ile Ala Ser Asp Leu Pro 
            900         


<210>  280
<211>  918
<212>  PRT
<213>  Homo sapiens

<400>  280

Met Glu His Gly Thr Leu Leu Ala Gln Pro Gly Leu Trp Thr Arg Asp 
1               5                   10                  15      


Thr Ser Trp Ala Leu Leu Tyr Phe Leu Cys Tyr Ile Leu Pro Gln Thr 
            20                  25                  30          


Ala Pro Gln Val Leu Arg Ile Gly Gly Ile Phe Glu Thr Val Glu Asn 
        35                  40                  45              


Glu Pro Val Asn Val Glu Glu Leu Ala Phe Lys Phe Ala Val Thr Ser 
    50                  55                  60                  


Ile Asn Arg Asn Arg Thr Leu Met Pro Asn Thr Thr Leu Thr Tyr Asp 
65                  70                  75                  80  


Ile Gln Arg Ile Asn Leu Phe Asp Ser Phe Glu Ala Ser Arg Arg Ala 
                85                  90                  95      


Cys Asp Gln Leu Ala Leu Gly Val Ala Ala Leu Phe Gly Pro Ser His 
            100                 105                 110         


Ser Ser Ser Val Ser Ala Val Gln Ser Ile Cys Asn Ala Leu Glu Val 
        115                 120                 125             


Pro His Ile Gln Thr Arg Trp Lys His Pro Ser Val Asp Asn Lys Asp 
    130                 135                 140                 


Leu Phe Tyr Ile Asn Leu Tyr Pro Asp Tyr Ala Ala Ile Ser Arg Ala 
145                 150                 155                 160 


Ile Leu Asp Leu Val Leu Tyr Tyr Asn Trp Lys Thr Val Thr Val Val 
                165                 170                 175     


Tyr Glu Asp Ser Thr Gly Leu Ile Arg Leu Gln Glu Leu Ile Lys Ala 
            180                 185                 190         


Pro Ser Arg Tyr Asn Ile Lys Ile Lys Ile Arg Gln Leu Pro Ser Gly 
        195                 200                 205             


Asn Lys Asp Ala Lys Pro Leu Leu Lys Glu Met Lys Lys Gly Lys Glu 
    210                 215                 220                 


Phe Tyr Val Ile Phe Asp Cys Ser His Glu Thr Ala Ala Glu Ile Leu 
225                 230                 235                 240 


Lys Gln Ile Leu Phe Met Gly Met Met Thr Glu Tyr Tyr His Tyr Phe 
                245                 250                 255     


Phe Thr Thr Leu Asp Leu Phe Ala Leu Asp Leu Glu Leu Tyr Arg Tyr 
            260                 265                 270         


Ser Gly Val Asn Met Thr Gly Phe Arg Leu Leu Asn Ile Asp Asn Pro 
        275                 280                 285             


His Val Ser Ser Ile Ile Glu Lys Trp Ser Met Glu Arg Leu Gln Ala 
    290                 295                 300                 


Pro Pro Arg Pro Glu Thr Gly Leu Leu Asp Gly Met Met Thr Thr Glu 
305                 310                 315                 320 


Ala Ala Leu Met Tyr Asp Ala Val Tyr Met Val Ala Ile Ala Ser His 
                325                 330                 335     


Arg Ala Ser Gln Leu Thr Val Ser Ser Leu Gln Cys His Arg His Lys 
            340                 345                 350         


Pro Trp Arg Leu Gly Pro Arg Phe Met Asn Leu Ile Lys Glu Ala Arg 
        355                 360                 365             


Trp Asp Gly Leu Thr Gly His Ile Thr Phe Asn Lys Thr Asn Gly Leu 
    370                 375                 380                 


Arg Lys Asp Phe Asp Leu Asp Ile Ile Ser Leu Lys Glu Glu Gly Thr 
385                 390                 395                 400 


Glu Lys Ala Ala Gly Glu Val Ser Lys His Leu Tyr Lys Val Trp Lys 
                405                 410                 415     


Lys Ile Gly Ile Trp Asn Ser Asn Ser Gly Leu Asn Met Thr Asp Ser 
            420                 425                 430         


Asn Lys Asp Lys Ser Ser Asn Ile Thr Asp Ser Leu Ala Asn Arg Thr 
        435                 440                 445             


Leu Ile Val Thr Thr Ile Leu Glu Glu Pro Tyr Val Met Tyr Arg Lys 
    450                 455                 460                 


Ser Asp Lys Pro Leu Tyr Gly Asn Asp Arg Phe Glu Gly Tyr Cys Leu 
465                 470                 475                 480 


Asp Leu Leu Lys Glu Leu Ser Asn Ile Leu Gly Phe Ile Tyr Asp Val 
                485                 490                 495     


Lys Leu Val Pro Asp Gly Lys Tyr Gly Ala Gln Asn Asp Lys Gly Glu 
            500                 505                 510         


Trp Asn Gly Met Val Lys Glu Leu Ile Asp His Arg Ala Asp Leu Ala 
        515                 520                 525             


Val Ala Pro Leu Thr Ile Thr Tyr Val Arg Glu Lys Val Ile Asp Phe 
    530                 535                 540                 


Ser Lys Pro Phe Met Thr Leu Gly Ile Ser Ile Leu Tyr Arg Lys Pro 
545                 550                 555                 560 


Asn Gly Thr Asn Pro Gly Val Phe Ser Phe Leu Asn Pro Leu Ser Pro 
                565                 570                 575     


Asp Ile Trp Met Tyr Val Leu Leu Ala Cys Leu Gly Val Ser Cys Val 
            580                 585                 590         


Leu Phe Val Ile Ala Arg Phe Thr Pro Tyr Glu Trp Tyr Asn Pro His 
        595                 600                 605             


Pro Cys Asn Pro Asp Ser Asp Val Val Glu Asn Asn Phe Thr Leu Leu 
    610                 615                 620                 


Asn Ser Phe Trp Phe Gly Val Gly Ala Leu Met Gln Gln Gly Ser Glu 
625                 630                 635                 640 


Leu Met Pro Lys Ala Leu Ser Thr Arg Ile Val Gly Gly Ile Trp Trp 
                645                 650                 655     


Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala Ala 
            660                 665                 670         


Phe Leu Thr Val Glu Arg Met Glu Ser Pro Ile Asp Ser Ala Asp Asp 
        675                 680                 685             


Leu Ala Lys Gln Thr Lys Ile Glu Tyr Gly Ala Val Arg Asp Gly Ser 
    690                 695                 700                 


Thr Met Thr Phe Phe Lys Lys Ser Lys Ile Ser Thr Tyr Glu Lys Met 
705                 710                 715                 720 


Trp Ala Phe Met Ser Ser Arg Gln Gln Thr Ala Leu Val Arg Asn Ser 
                725                 730                 735     


Asp Glu Gly Ile Gln Arg Val Leu Thr Thr Asp Tyr Ala Leu Leu Met 
            740                 745                 750         


Glu Ser Thr Ser Ile Glu Tyr Val Thr Gln Arg Asn Cys Asn Leu Thr 
        755                 760                 765             


Gln Ile Gly Gly Leu Ile Asp Ser Lys Gly Tyr Gly Val Gly Thr Pro 
    770                 775                 780                 


Ile Gly Ser Pro Tyr Arg Asp Lys Ile Thr Ile Ala Ile Leu Gln Leu 
785                 790                 795                 800 


Gln Glu Glu Gly Lys Leu His Met Met Lys Glu Lys Trp Trp Arg Gly 
                805                 810                 815     


Asn Gly Cys Pro Glu Glu Asp Asn Lys Glu Ala Ser Ala Leu Gly Val 
            820                 825                 830         


Glu Asn Ile Gly Gly Ile Phe Ile Val Leu Ala Ala Gly Leu Val Leu 
        835                 840                 845             


Ser Val Phe Val Ala Ile Gly Glu Phe Ile Tyr Lys Ser Arg Lys Asn 
    850                 855                 860                 


Asn Asp Ile Glu Gln Ala Phe Cys Phe Phe Tyr Gly Leu Gln Cys Lys 
865                 870                 875                 880 


Gln Thr His Pro Thr Asn Ser Thr Ser Gly Thr Thr Leu Ser Thr Asp 
                885                 890                 895     


Leu Glu Cys Gly Lys Leu Ile Arg Glu Glu Arg Gly Ile Arg Lys Gln 
            900                 905                 910         


Ser Ser Val His Thr Val 
        915             


<210>  281
<211>  919
<212>  PRT
<213>  Homo sapiens

<400>  281

Met Thr Ala Pro Trp Arg Arg Leu Arg Ser Leu Val Trp Glu Tyr Trp 
1               5                   10                  15      


Ala Gly Leu Leu Val Cys Ala Phe Trp Ile Pro Asp Ser Arg Gly Met 
            20                  25                  30          


Pro His Val Ile Arg Ile Gly Gly Ile Phe Glu Tyr Ala Asp Gly Pro 
        35                  40                  45              


Asn Ala Gln Val Met Asn Ala Glu Glu His Ala Phe Arg Phe Ser Ala 
    50                  55                  60                  


Asn Ile Ile Asn Arg Asn Arg Thr Leu Leu Pro Asn Thr Thr Leu Thr 
65                  70                  75                  80  


Tyr Asp Ile Gln Arg Ile His Phe His Asp Ser Phe Glu Ala Thr Lys 
                85                  90                  95      


Lys Ala Cys Asp Gln Leu Ala Leu Gly Val Val Ala Ile Phe Gly Pro 
            100                 105                 110         


Ser Gln Gly Ser Cys Thr Asn Ala Val Gln Ser Ile Cys Asn Ala Leu 
        115                 120                 125             


Glu Val Pro His Ile Gln Leu Arg Trp Lys His His Pro Leu Asp Asn 
    130                 135                 140                 


Lys Asp Thr Phe Tyr Val Asn Leu Tyr Pro Asp Tyr Ala Ser Leu Ser 
145                 150                 155                 160 


His Ala Ile Leu Asp Leu Val Gln Tyr Leu Lys Trp Arg Ser Ala Thr 
                165                 170                 175     


Val Val Tyr Asp Asp Ser Thr Gly Leu Ile Arg Leu Gln Glu Leu Ile 
            180                 185                 190         


Met Ala Pro Ser Arg Tyr Asn Ile Arg Leu Lys Ile Arg Gln Leu Pro 
        195                 200                 205             


Ile Asp Ser Asp Asp Ser Arg Pro Leu Leu Lys Glu Met Lys Arg Gly 
    210                 215                 220                 


Arg Glu Phe Arg Ile Ile Phe Asp Cys Ser His Thr Met Ala Ala Gln 
225                 230                 235                 240 


Ile Leu Lys Gln Ala Met Ala Met Gly Met Met Thr Glu Tyr Tyr His 
                245                 250                 255     


Phe Ile Phe Thr Thr Leu Asp Leu Tyr Ala Leu Asp Leu Glu Pro Tyr 
            260                 265                 270         


Arg Tyr Ser Gly Val Asn Leu Thr Gly Phe Arg Ile Leu Asn Val Asp 
        275                 280                 285             


Asn Pro His Val Ser Ala Ile Val Glu Lys Trp Ser Met Glu Arg Leu 
    290                 295                 300                 


Gln Ala Ala Pro Arg Ser Glu Ser Gly Leu Leu Asp Gly Val Met Met 
305                 310                 315                 320 


Thr Asp Ala Ala Leu Leu Tyr Asp Ala Val His Ile Val Ser Val Cys 
                325                 330                 335     


Tyr Gln Arg Ala Pro Gln Met Thr Val Asn Ser Leu Gln Cys His Arg 
            340                 345                 350         


His Lys Ala Trp Arg Phe Gly Gly Arg Phe Met Asn Phe Ile Lys Glu 
        355                 360                 365             


Ala Gln Trp Glu Gly Leu Thr Gly Arg Ile Val Phe Asn Lys Thr Ser 
    370                 375                 380                 


Gly Leu Arg Thr Asp Phe Asp Leu Asp Ile Ile Ser Leu Lys Glu Asp 
385                 390                 395                 400 


Gly Leu Glu Lys Val Gly Val Trp Ser Pro Ala Asp Gly Leu Asn Ile 
                405                 410                 415     


Thr Glu Val Ala Lys Gly Arg Gly Pro Asn Val Thr Asp Ser Leu Thr 
            420                 425                 430         


Asn Arg Ser Leu Ile Val Thr Thr Val Leu Glu Glu Pro Phe Val Met 
        435                 440                 445             


Phe Arg Lys Ser Asp Arg Thr Leu Tyr Gly Asn Asp Arg Phe Glu Gly 
    450                 455                 460                 


Tyr Cys Ile Asp Leu Leu Lys Glu Leu Ala His Ile Leu Gly Phe Ser 
465                 470                 475                 480 


Tyr Glu Ile Arg Leu Val Glu Asp Gly Lys Tyr Gly Ala Gln Asp Asp 
                485                 490                 495     


Lys Gly Gln Trp Asn Gly Met Val Lys Glu Leu Ile Asp His Lys Ala 
            500                 505                 510         


Asp Leu Ala Val Ala Pro Leu Thr Ile Thr His Val Arg Glu Lys Ala 
        515                 520                 525             


Ile Asp Phe Ser Lys Pro Phe Met Thr Leu Gly Val Ser Ile Leu Tyr 
    530                 535                 540                 


Arg Lys Pro Asn Gly Thr Asn Pro Ser Val Phe Ser Phe Leu Asn Pro 
545                 550                 555                 560 


Leu Ser Pro Asp Ile Trp Met Tyr Val Leu Leu Ala Tyr Leu Gly Val 
                565                 570                 575     


Ser Cys Val Leu Phe Val Ile Ala Arg Phe Ser Pro Tyr Glu Trp Tyr 
            580                 585                 590         


Asp Ala His Pro Cys Asn Pro Gly Ser Glu Val Val Glu Asn Asn Phe 
        595                 600                 605             


Thr Leu Leu Asn Ser Phe Trp Phe Gly Met Gly Ser Leu Met Gln Gln 
    610                 615                 620                 


Gly Ser Glu Leu Met Pro Lys Ala Leu Ser Thr Arg Ile Ile Gly Gly 
625                 630                 635                 640 


Ile Trp Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn 
                645                 650                 655     


Leu Ala Ala Phe Leu Thr Val Glu Arg Met Glu Ser Pro Ile Asp Ser 
            660                 665                 670         


Ala Asp Asp Leu Ala Lys Gln Thr Lys Ile Glu Tyr Gly Ala Val Lys 
        675                 680                 685             


Asp Gly Ala Thr Met Thr Phe Phe Lys Lys Ser Lys Ile Ser Thr Phe 
    690                 695                 700                 


Glu Lys Met Trp Ala Phe Met Ser Ser Lys Pro Ser Ala Leu Val Lys 
705                 710                 715                 720 


Asn Asn Glu Glu Gly Ile Gln Arg Ala Leu Thr Ala Asp Tyr Ala Leu 
                725                 730                 735     


Leu Met Glu Ser Thr Thr Ile Glu Tyr Val Thr Gln Arg Asn Cys Asn 
            740                 745                 750         


Leu Thr Gln Ile Gly Gly Leu Ile Asp Ser Lys Gly Tyr Gly Ile Gly 
        755                 760                 765             


Thr Pro Met Gly Ser Pro Tyr Arg Asp Lys Ile Thr Ile Ala Ile Leu 
    770                 775                 780                 


Gln Leu Gln Glu Glu Asp Lys Leu His Ile Met Lys Glu Lys Trp Trp 
785                 790                 795                 800 


Arg Gly Ser Gly Cys Pro Glu Glu Glu Asn Lys Glu Ala Ser Ala Leu 
                805                 810                 815     


Gly Ile Gln Lys Ile Gly Gly Ile Phe Ile Val Leu Ala Ala Gly Leu 
            820                 825                 830         


Val Leu Ser Val Leu Val Ala Val Gly Glu Phe Val Tyr Lys Leu Arg 
        835                 840                 845             


Lys Thr Ala Glu Arg Glu Gln Arg Ser Phe Cys Ser Thr Val Ala Asp 
    850                 855                 860                 


Glu Ile Arg Phe Ser Leu Thr Cys Gln Arg Arg Val Lys His Lys Pro 
865                 870                 875                 880 


Gln Pro Pro Met Met Val Lys Thr Asp Ala Val Ile Asn Met His Thr 
                885                 890                 895     


Phe Asn Asp Arg Arg Leu Pro Gly Lys Asp Ser Met Ala Cys Ser Thr 
            900                 905                 910         


Ser Leu Ala Pro Val Phe Pro 
        915                 


<210>  282
<211>  885
<212>  PRT
<213>  Homo sapiens

<400>  282

Met Ser Thr Met Arg Leu Leu Thr Leu Ala Leu Leu Phe Ser Cys Ser 
1               5                   10                  15      


Val Ala Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile Gly Ala Val 
            20                  25                  30          


Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala Val Asn Gln 
        35                  40                  45              


Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn Ala Thr Ser 
    50                  55                  60                  


Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser Val Cys Glu 
65                  70                  75                  80  


Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser His Pro Pro 
                85                  90                  95      


Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr Thr Ala Gly 
            100                 105                 110         


Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met Ser Ile Tyr 
        115                 120                 125             


Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val Pro Pro Tyr 
    130                 135                 140                 


Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val Tyr Ser Trp 
145                 150                 155                 160 


Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly Arg Ala Ala 
                165                 170                 175     


Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser Lys Ala Glu 
            180                 185                 190         


Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn Val Thr Ala Leu Leu 
        195                 200                 205             


Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile Ile Leu Ser Ala Ser 
    210                 215                 220                 


Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala Ala Met Leu Asn Met 
225                 230                 235                 240 


Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu Arg Glu Ile Ser Gly 
                245                 250                 255     


Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu Gly Leu Gln Leu Ile 
            260                 265                 270         


Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp Ala Val Gly Val Val 
        275                 280                 285             


Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu Asn Ile Thr Asp Pro 
    290                 295                 300                 


Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp Lys Thr Gly Pro Leu 
305                 310                 315                 320 


Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala Asp Gly Val Thr Gly 
                325                 330                 335     


Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys Phe Ala Asn Tyr Ser 
            340                 345                 350         


Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln Val Gly Ile Tyr Asn 
        355                 360                 365             


Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile Ile Trp Pro Gly Gly 
    370                 375                 380                 


Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met Ser Thr Arg Leu Lys Ile 
385                 390                 395                 400 


Val Thr Ile His Gln Glu Pro Phe Val Tyr Val Lys Pro Thr Leu Ser 
                405                 410                 415     


Asp Gly Thr Cys Lys Glu Glu Phe Thr Val Asn Gly Asp Pro Val Lys 
            420                 425                 430         


Lys Val Ile Cys Thr Gly Pro Asn Asp Thr Ser Pro Gly Ser Pro Arg 
        435                 440                 445             


His Thr Val Pro Gln Cys Cys Tyr Gly Phe Cys Ile Asp Leu Leu Ile 
    450                 455                 460                 


Lys Leu Ala Arg Thr Met Asn Phe Thr Tyr Glu Val His Leu Val Ala 
465                 470                 475                 480 


Asp Gly Lys Phe Gly Thr Gln Glu Arg Val Asn Asn Ser Asn Lys Lys 
                485                 490                 495     


Glu Trp Asn Gly Met Met Gly Glu Leu Leu Ser Gly Gln Ala Asp Met 
            500                 505                 510         


Ile Val Ala Pro Leu Thr Ile Asn Asn Glu Arg Ala Gln Tyr Ile Glu 
        515                 520                 525             


Phe Ser Lys Pro Phe Lys Tyr Gln Gly Leu Thr Ile Leu Val Lys Lys 
    530                 535                 540                 


Glu Ile Pro Arg Ser Thr Leu Asp Ser Phe Met Gln Pro Phe Gln Ser 
545                 550                 555                 560 


Thr Leu Trp Leu Leu Val Gly Leu Ser Val His Val Val Ala Val Met 
                565                 570                 575     


Leu Tyr Leu Leu Asp Arg Phe Ser Pro Phe Gly Arg Phe Lys Val Asn 
            580                 585                 590         


Ser Glu Glu Glu Glu Glu Asp Ala Leu Thr Leu Ser Ser Ala Met Trp 
        595                 600                 605             


Phe Ser Trp Gly Val Leu Leu Asn Ser Gly Ile Gly Glu Gly Ala Pro 
    610                 615                 620                 


Arg Ser Phe Ser Ala Arg Ile Leu Gly Met Val Trp Ala Gly Phe Ala 
625                 630                 635                 640 


Met Ile Ile Val Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu Val 
                645                 650                 655     


Leu Asp Arg Pro Glu Glu Arg Ile Thr Gly Ile Asn Asp Pro Arg Leu 
            660                 665                 670         


Arg Asn Pro Ser Asp Lys Phe Ile Tyr Ala Thr Val Lys Gln Ser Ser 
        675                 680                 685             


Val Asp Ile Tyr Phe Arg Arg Gln Val Glu Leu Ser Thr Met Tyr Arg 
    690                 695                 700                 


His Met Glu Lys His Asn Tyr Glu Ser Ala Ala Glu Ala Ile Gln Ala 
705                 710                 715                 720 


Val Arg Asp Asn Lys Leu His Ala Phe Ile Trp Asp Ser Ala Val Leu 
                725                 730                 735     


Glu Phe Glu Ala Ser Gln Lys Cys Asp Leu Val Thr Thr Gly Glu Leu 
            740                 745                 750         


Phe Phe Arg Ser Gly Phe Gly Ile Gly Met Arg Lys Asp Ser Pro Trp 
        755                 760                 765             


Lys Gln Asn Val Ser Leu Ser Ile Leu Lys Ser His Glu Asn Gly Phe 
    770                 775                 780                 


Met Glu Asp Leu Asp Lys Thr Trp Val Arg Tyr Gln Glu Cys Asp Ser 
785                 790                 795                 800 


Arg Ser Asn Ala Pro Ala Thr Leu Thr Phe Glu Asn Met Ala Gly Val 
                805                 810                 815     


Phe Met Leu Val Ala Gly Gly Ile Val Ala Gly Ile Phe Leu Ile Phe 
            820                 825                 830         


Ile Glu Ile Ala Tyr Lys Arg His Lys Asp Ala Arg Arg Lys Gln Met 
        835                 840                 845             


Gln Leu Ala Phe Ala Ala Val Asn Val Trp Arg Lys Asn Leu Gln Gln 
    850                 855                 860                 


Tyr His Pro Thr Asp Ile Thr Gly Pro Leu Asn Leu Ser Asp Pro Ser 
865                 870                 875                 880 


Val Ser Thr Val Val 
                885 


<210>  283
<211>  1464
<212>  PRT
<213>  Homo sapiens

<400>  283

Met Gly Arg Val Gly Tyr Trp Thr Leu Leu Val Leu Pro Ala Leu Leu 
1               5                   10                  15      


Val Trp Arg Gly Pro Ala Pro Ser Ala Ala Ala Glu Lys Gly Pro Pro 
            20                  25                  30          


Ala Leu Asn Ile Ala Val Met Leu Gly His Ser His Asp Val Thr Glu 
        35                  40                  45              


Arg Glu Leu Arg Thr Leu Trp Gly Pro Glu Gln Ala Ala Gly Leu Pro 
    50                  55                  60                  


Leu Asp Val Asn Val Val Ala Leu Leu Met Asn Arg Thr Asp Pro Lys 
65                  70                  75                  80  


Ser Leu Ile Thr His Val Cys Asp Leu Met Ser Gly Ala Arg Ile His 
                85                  90                  95      


Gly Leu Val Phe Gly Asp Asp Thr Asp Gln Glu Ala Val Ala Gln Met 
            100                 105                 110         


Leu Asp Phe Ile Ser Ser His Thr Phe Val Pro Ile Leu Gly Ile His 
        115                 120                 125             


Gly Gly Ala Ser Met Ile Met Ala Asp Lys Asp Pro Thr Ser Thr Phe 
    130                 135                 140                 


Phe Gln Phe Gly Ala Ser Ile Gln Gln Gln Ala Thr Val Met Leu Lys 
145                 150                 155                 160 


Ile Met Gln Asp Tyr Asp Trp His Val Phe Ser Leu Val Thr Thr Ile 
                165                 170                 175     


Phe Pro Gly Tyr Arg Glu Phe Ile Ser Phe Val Lys Thr Thr Val Asp 
            180                 185                 190         


Asn Ser Phe Val Gly Trp Asp Met Gln Asn Val Ile Thr Leu Asp Thr 
        195                 200                 205             


Ser Phe Glu Asp Ala Lys Thr Gln Val Gln Leu Lys Lys Ile His Ser 
    210                 215                 220                 


Ser Val Ile Leu Leu Tyr Cys Ser Lys Asp Glu Ala Val Leu Ile Leu 
225                 230                 235                 240 


Ser Glu Ala Arg Ser Leu Gly Leu Thr Gly Tyr Asp Phe Phe Trp Ile 
                245                 250                 255     


Val Pro Ser Leu Val Ser Gly Asn Thr Glu Leu Ile Pro Lys Glu Phe 
            260                 265                 270         


Pro Ser Gly Leu Ile Ser Val Ser Tyr Asp Asp Trp Asp Tyr Ser Leu 
        275                 280                 285             


Glu Ala Arg Val Arg Asp Gly Ile Gly Ile Leu Thr Thr Ala Ala Ser 
    290                 295                 300                 


Ser Met Leu Glu Lys Phe Ser Tyr Ile Pro Glu Ala Lys Ala Ser Cys 
305                 310                 315                 320 


Tyr Gly Gln Met Glu Arg Pro Glu Val Pro Met His Thr Leu His Pro 
                325                 330                 335     


Phe Met Val Asn Val Thr Trp Asp Gly Lys Asp Leu Ser Phe Thr Glu 
            340                 345                 350         


Glu Gly Tyr Gln Val His Pro Arg Leu Val Val Ile Val Leu Asn Lys 
        355                 360                 365             


Asp Arg Glu Trp Glu Lys Val Gly Lys Trp Glu Asn His Thr Leu Ser 
    370                 375                 380                 


Leu Arg His Ala Val Trp Pro Arg Tyr Lys Ser Phe Ser Asp Cys Glu 
385                 390                 395                 400 


Pro Asp Asp Asn His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe 
                405                 410                 415     


Val Ile Val Glu Asp Ile Asp Pro Leu Thr Glu Thr Cys Val Arg Asn 
            420                 425                 430         


Thr Val Pro Cys Arg Lys Phe Val Lys Ile Asn Asn Ser Thr Asn Glu 
        435                 440                 445             


Gly Met Asn Val Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu 
    450                 455                 460                 


Lys Lys Leu Ser Arg Thr Val Lys Phe Thr Tyr Asp Leu Tyr Leu Val 
465                 470                 475                 480 


Thr Asn Gly Lys His Gly Lys Lys Val Asn Asn Val Trp Asn Gly Met 
                485                 490                 495     


Ile Gly Glu Val Val Tyr Gln Arg Ala Val Met Ala Val Gly Ser Leu 
            500                 505                 510         


Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro Phe 
        515                 520                 525             


Val Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr Val 
    530                 535                 540                 


Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Ser Val Trp Val Met 
545                 550                 555                 560 


Met Phe Val Met Leu Leu Ile Val Ser Ala Ile Ala Val Phe Val Phe 
                565                 570                 575     


Glu Tyr Phe Ser Pro Val Gly Tyr Asn Arg Asn Leu Ala Lys Gly Lys 
            580                 585                 590         


Ala Pro His Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu Leu 
        595                 600                 605             


Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys Gly 
    610                 615                 620                 


Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val Ile 
625                 630                 635                 640 


Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu 
                645                 650                 655     


Glu Phe Val Asp Gln Val Thr Gly Leu Ser Asp Lys Lys Phe Gln Arg 
            660                 665                 670         


Pro His Asp Tyr Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn Gly 
        675                 680                 685             


Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Pro Tyr Met His Gln Tyr 
    690                 695                 700                 


Met Thr Lys Phe Asn Gln Lys Gly Val Glu Asp Ala Leu Val Ser Leu 
705                 710                 715                 720 


Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn 
                725                 730                 735     


Tyr Lys Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser 
            740                 745                 750         


Gly Tyr Ile Phe Ala Thr Thr Gly Tyr Gly Ile Ala Leu Gln Lys Gly 
        755                 760                 765             


Ser Pro Trp Lys Arg Gln Ile Asp Leu Ala Leu Leu Gln Phe Val Gly 
    770                 775                 780                 


Asp Gly Glu Met Glu Glu Leu Glu Thr Leu Trp Leu Thr Gly Ile Cys 
785                 790                 795                 800 


His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp Asn 
                805                 810                 815     


Met Ala Gly Val Phe Tyr Met Leu Ala Ala Ala Met Ala Leu Ser Leu 
            820                 825                 830         


Ile Thr Phe Ile Trp Glu His Leu Phe Tyr Trp Lys Leu Arg Phe Cys 
        835                 840                 845             


Phe Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Phe Ser Ile Ser 
    850                 855                 860                 


Arg Gly Ile Tyr Ser Cys Ile His Gly Val His Ile Glu Glu Lys Lys 
865                 870                 875                 880 


Lys Ser Pro Asp Phe Asn Leu Thr Gly Ser Gln Ser Asn Met Leu Lys 
                885                 890                 895     


Leu Leu Arg Ser Ala Lys Asn Ile Ser Ser Met Ser Asn Met Asn Ser 
            900                 905                 910         


Ser Arg Met Asp Ser Pro Lys Arg Ala Ala Asp Phe Ile Gln Arg Gly 
        915                 920                 925             


Ser Leu Ile Met Asp Met Val Ser Asp Lys Gly Asn Leu Met Tyr Ser 
    930                 935                 940                 


Asp Asn Arg Ser Phe Gln Gly Lys Glu Ser Ile Phe Gly Asp Asn Met 
945                 950                 955                 960 


Asn Glu Leu Gln Thr Phe Val Ala Asn Arg Gln Lys Asp Asn Leu Asn 
                965                 970                 975     


Asn Tyr Val Phe Gln Gly Gln His Pro Leu Thr Leu Asn Glu Ser Asn 
            980                 985                 990         


Pro Asn Thr Val Glu Val Ala Val  Ser Thr Glu Ser Lys  Ala Asn Ser 
        995                 1000                 1005             


Arg Pro  Arg Gln Leu Trp Lys  Lys Ser Val Asp Ser  Ile Arg Gln 
    1010                 1015                 1020             


Asp Ser  Leu Ser Gln Asn Pro  Val Ser Gln Arg Asp  Glu Ala Thr 
    1025                 1030                 1035             


Ala Glu  Asn Arg Thr His Ser  Leu Lys Ser Pro Arg  Tyr Leu Pro 
    1040                 1045                 1050             


Glu Glu  Met Ala His Ser Asp  Ile Ser Glu Thr Ser  Asn Arg Ala 
    1055                 1060                 1065             


Thr Cys  His Arg Glu Pro Asp  Asn Ser Lys Asn His  Lys Thr Lys 
    1070                 1075                 1080             


Asp Asn  Phe Lys Arg Ser Val  Ala Ser Lys Tyr Pro  Lys Asp Cys 
    1085                 1090                 1095             


Ser Glu  Val Glu Arg Thr Tyr  Leu Lys Thr Lys Ser  Ser Ser Pro 
    1100                 1105                 1110             


Arg Asp  Lys Ile Tyr Thr Ile  Asp Gly Glu Lys Glu  Pro Gly Phe 
    1115                 1120                 1125             


His Leu  Asp Pro Pro Gln Phe  Val Glu Asn Val Thr  Leu Pro Glu 
    1130                 1135                 1140             


Asn Val  Asp Phe Pro Asp Pro  Tyr Gln Asp Pro Ser  Glu Asn Phe 
    1145                 1150                 1155             


Arg Lys  Gly Asp Ser Thr Leu  Pro Met Asn Arg Asn  Pro Leu His 
    1160                 1165                 1170             


Asn Glu  Glu Gly Leu Ser Asn  Asn Asp Gln Tyr Lys  Leu Tyr Ser 
    1175                 1180                 1185             


Lys His  Phe Thr Leu Lys Asp  Lys Gly Ser Pro His  Ser Glu Thr 
    1190                 1195                 1200             


Ser Glu  Arg Tyr Arg Gln Asn  Ser Thr His Cys Arg  Ser Cys Leu 
    1205                 1210                 1215             


Ser Asn  Met Pro Thr Tyr Ser  Gly His Phe Thr Met  Arg Ser Pro 
    1220                 1225                 1230             


Phe Lys  Cys Asp Ala Cys Leu  Arg Met Gly Asn Leu  Tyr Asp Ile 
    1235                 1240                 1245             


Asp Glu  Asp Gln Met Leu Gln  Glu Thr Gly Asn Pro  Ala Thr Gly 
    1250                 1255                 1260             


Glu Gln  Val Tyr Gln Gln Asp  Trp Ala Gln Asn Asn  Ala Leu Gln 
    1265                 1270                 1275             


Leu Gln  Lys Asn Lys Leu Arg  Ile Ser Arg Gln His  Ser Tyr Asp 
    1280                 1285                 1290             


Asn Ile  Val Asp Lys Pro Arg  Glu Leu Asp Leu Ser  Arg Pro Ser 
    1295                 1300                 1305             


Arg Ser  Ile Ser Leu Lys Asp  Arg Glu Arg Leu Leu  Glu Gly Asn 
    1310                 1315                 1320             


Phe Tyr  Gly Ser Leu Phe Ser  Val Pro Ser Ser Lys  Leu Ser Gly 
    1325                 1330                 1335             


Lys Lys  Ser Ser Leu Phe Pro  Gln Gly Leu Glu Asp  Ser Lys Arg 
    1340                 1345                 1350             


Ser Lys  Ser Leu Leu Pro Asp  His Thr Ser Asp Asn  Pro Phe Leu 
    1355                 1360                 1365             


His Ser  His Arg Asp Asp Gln  Arg Leu Val Ile Gly  Arg Cys Pro 
    1370                 1375                 1380             


Ser Asp  Pro Tyr Lys His Ser  Leu Pro Ser Gln Ala  Val Asn Asp 
    1385                 1390                 1395             


Ser Tyr  Leu Arg Ser Ser Leu  Arg Ser Thr Ala Ser  Tyr Cys Ser 
    1400                 1405                 1410             


Arg Asp  Ser Arg Gly His Asn  Asp Val Tyr Ile Ser  Glu His Val 
    1415                 1420                 1425             


Met Pro  Tyr Ala Ala Asn Lys  Asn Asn Met Tyr Ser  Thr Pro Arg 
    1430                 1435                 1440             


Val Leu  Asn Ser Cys Ser Asn  Arg Arg Val Tyr Lys  Lys Met Pro 
    1445                 1450                 1455             


Ser Ile  Glu Ser Asp Val 
    1460                 


<210>  284
<211>  1484
<212>  PRT
<213>  Homo sapiens

<400>  284

Met Lys Pro Arg Ala Glu Cys Cys Ser Pro Lys Phe Trp Leu Val Leu 
1               5                   10                  15      


Ala Val Leu Ala Val Ser Gly Ser Arg Ala Arg Ser Gln Lys Ser Pro 
            20                  25                  30          


Pro Ser Ile Gly Ile Ala Val Ile Leu Val Gly Thr Ser Asp Glu Val 
        35                  40                  45              


Ala Ile Lys Asp Ala His Glu Lys Asp Asp Phe His His Leu Ser Val 
    50                  55                  60                  


Val Pro Arg Val Glu Leu Val Ala Met Asn Glu Thr Asp Pro Lys Ser 
65                  70                  75                  80  


Ile Ile Thr Arg Ile Cys Asp Leu Met Ser Asp Arg Lys Ile Gln Gly 
                85                  90                  95      


Val Val Phe Ala Asp Asp Thr Asp Gln Glu Ala Ile Ala Gln Ile Leu 
            100                 105                 110         


Asp Phe Ile Ser Ala Gln Thr Leu Thr Pro Ile Leu Gly Ile His Gly 
        115                 120                 125             


Gly Ser Ser Met Ile Met Ala Asp Lys Asp Glu Ser Ser Met Phe Phe 
    130                 135                 140                 


Gln Phe Gly Pro Ser Ile Glu Gln Gln Ala Ser Val Met Leu Asn Ile 
145                 150                 155                 160 


Met Glu Glu Tyr Asp Trp Tyr Ile Phe Ser Ile Val Thr Thr Tyr Phe 
                165                 170                 175     


Pro Gly Tyr Gln Asp Phe Val Asn Lys Ile Arg Ser Thr Ile Glu Asn 
            180                 185                 190         


Ser Phe Val Gly Trp Glu Leu Glu Glu Val Leu Leu Leu Asp Met Ser 
        195                 200                 205             


Leu Asp Asp Gly Asp Ser Lys Ile Gln Asn Gln Leu Lys Lys Leu Gln 
    210                 215                 220                 


Ser Pro Ile Ile Leu Leu Tyr Cys Thr Lys Glu Glu Ala Thr Tyr Ile 
225                 230                 235                 240 


Phe Glu Val Ala Asn Ser Val Gly Leu Thr Gly Tyr Gly Tyr Thr Trp 
                245                 250                 255     


Ile Val Pro Ser Leu Val Ala Gly Asp Thr Asp Thr Val Pro Ala Glu 
            260                 265                 270         


Phe Pro Thr Gly Leu Ile Ser Val Ser Tyr Asp Glu Trp Asp Tyr Gly 
        275                 280                 285             


Leu Pro Ala Arg Val Arg Asp Gly Ile Ala Ile Ile Thr Thr Ala Ala 
    290                 295                 300                 


Ser Asp Met Leu Ser Glu His Ser Phe Ile Pro Glu Pro Lys Ser Ser 
305                 310                 315                 320 


Cys Tyr Asn Thr His Glu Lys Arg Ile Tyr Gln Ser Asn Met Leu Asn 
                325                 330                 335     


Arg Tyr Leu Ile Asn Val Thr Phe Glu Gly Arg Asn Leu Ser Phe Ser 
            340                 345                 350         


Glu Asp Gly Tyr Gln Met His Pro Lys Leu Val Ile Ile Leu Leu Asn 
        355                 360                 365             


Lys Glu Arg Lys Trp Glu Arg Val Gly Lys Trp Lys Asp Lys Ser Leu 
    370                 375                 380                 


Gln Met Lys Tyr Tyr Val Trp Pro Arg Met Cys Pro Glu Thr Glu Glu 
385                 390                 395                 400 


Gln Glu Asp Asp His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe 
                405                 410                 415     


Val Ile Val Glu Ser Val Asp Pro Leu Ser Gly Thr Cys Met Arg Asn 
            420                 425                 430         


Thr Val Pro Cys Gln Lys Arg Ile Val Thr Glu Asn Lys Thr Asp Glu 
        435                 440                 445             


Glu Pro Gly Tyr Ile Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile 
    450                 455                 460                 


Leu Lys Lys Ile Ser Lys Ser Val Lys Phe Thr Tyr Asp Leu Tyr Leu 
465                 470                 475                 480 


Val Thr Asn Gly Lys His Gly Lys Lys Ile Asn Gly Thr Trp Asn Gly 
                485                 490                 495     


Met Ile Gly Glu Val Val Met Lys Arg Ala Tyr Met Ala Val Gly Ser 
            500                 505                 510         


Leu Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro 
        515                 520                 525             


Phe Ile Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr 
    530                 535                 540                 


Val Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Asp Val Trp Val 
545                 550                 555                 560 


Met Met Phe Val Met Leu Leu Ile Val Ser Ala Val Ala Val Phe Val 
                565                 570                 575     


Phe Glu Tyr Phe Ser Pro Val Gly Tyr Asn Arg Cys Leu Ala Asp Gly 
            580                 585                 590         


Arg Glu Pro Gly Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu 
        595                 600                 605             


Leu Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys 
    610                 615                 620                 


Gly Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val 
625                 630                 635                 640 


Ile Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln 
                645                 650                 655     


Glu Glu Tyr Val Asp Gln Val Ser Gly Leu Ser Asp Lys Lys Phe Gln 
            660                 665                 670         


Arg Pro Asn Asp Phe Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn 
        675                 680                 685             


Gly Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Ala Glu Met His Ala 
    690                 695                 700                 


Tyr Met Gly Lys Phe Asn Gln Arg Gly Val Asp Asp Ala Leu Leu Ser 
705                 710                 715                 720 


Leu Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu 
                725                 730                 735     


Asn Tyr Met Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly 
            740                 745                 750         


Ser Gly Lys Val Phe Ala Ser Thr Gly Tyr Gly Ile Ala Ile Gln Lys 
        755                 760                 765             


Asp Ser Gly Trp Lys Arg Gln Val Asp Leu Ala Ile Leu Gln Leu Phe 
    770                 775                 780                 


Gly Asp Gly Glu Met Glu Glu Leu Glu Ala Leu Trp Leu Thr Gly Ile 
785                 790                 795                 800 


Cys His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp 
                805                 810                 815     


Asn Met Ala Gly Val Phe Tyr Met Leu Gly Ala Ala Met Ala Leu Ser 
            820                 825                 830         


Leu Ile Thr Phe Ile Cys Glu His Leu Phe Tyr Trp Gln Phe Arg His 
        835                 840                 845             


Cys Phe Met Gly Val Cys Ser Gly Lys Pro Gly Met Val Phe Ser Ile 
    850                 855                 860                 


Ser Arg Gly Ile Tyr Ser Cys Ile His Gly Val Ala Ile Glu Glu Arg 
865                 870                 875                 880 


Gln Ser Val Met Asn Ser Pro Thr Ala Thr Met Asn Asn Thr His Ser 
                885                 890                 895     


Asn Ile Leu Arg Leu Leu Arg Thr Ala Lys Asn Met Ala Asn Leu Ser 
            900                 905                 910         


Gly Val Asn Gly Ser Pro Gln Ser Ala Leu Asp Phe Ile Arg Arg Glu 
        915                 920                 925             


Ser Ser Val Tyr Asp Ile Ser Glu His Arg Arg Ser Phe Thr His Ser 
    930                 935                 940                 


Asp Cys Lys Ser Tyr Asn Asn Pro Pro Cys Glu Glu Asn Leu Phe Ser 
945                 950                 955                 960 


Asp Tyr Ile Ser Glu Val Glu Arg Thr Phe Gly Asn Leu Gln Leu Lys 
                965                 970                 975     


Asp Ser Asn Val Tyr Gln Asp His Tyr His His His His Arg Pro His 
            980                 985                 990         


Ser Ile Gly Ser Ala Ser Ser Ile  Asp Gly Leu Tyr Asp  Cys Asp Asn 
        995                 1000                 1005             


Pro Pro  Phe Thr Thr Gln Ser  Arg Ser Ile Ser Lys  Lys Pro Leu 
    1010                 1015                 1020             


Asp Ile  Gly Leu Pro Ser Ser  Lys His Ser Gln Leu  Ser Asp Leu 
    1025                 1030                 1035             


Tyr Gly  Lys Phe Ser Phe Lys  Ser Asp Arg Tyr Ser  Gly His Asp 
    1040                 1045                 1050             


Asp Leu  Ile Arg Ser Asp Val  Ser Asp Ile Ser Thr  His Thr Val 
    1055                 1060                 1065             


Thr Tyr  Gly Asn Ile Glu Gly  Asn Ala Ala Lys Arg  Arg Lys Gln 
    1070                 1075                 1080             


Gln Tyr  Lys Asp Ser Leu Lys  Lys Arg Pro Ala Ser  Ala Lys Ser 
    1085                 1090                 1095             


Arg Arg  Glu Phe Asp Glu Ile  Glu Leu Ala Tyr Arg  Arg Arg Pro 
    1100                 1105                 1110             


Pro Arg  Ser Pro Asp His Lys  Arg Tyr Phe Arg Asp  Lys Glu Gly 
    1115                 1120                 1125             


Leu Arg  Asp Phe Tyr Leu Asp  Gln Phe Arg Thr Lys  Glu Asn Ser 
    1130                 1135                 1140             


Pro His  Trp Glu His Val Asp  Leu Thr Asp Ile Tyr  Lys Glu Arg 
    1145                 1150                 1155             


Ser Asp  Asp Phe Lys Arg Asp  Ser Val Ser Gly Gly  Gly Pro Cys 
    1160                 1165                 1170             


Thr Asn  Arg Ser His Ile Lys  His Gly Thr Gly Asp  Lys His Gly 
    1175                 1180                 1185             


Val Val  Ser Gly Val Pro Ala  Pro Trp Glu Lys Asn  Leu Thr Asn 
    1190                 1195                 1200             


Val Glu  Trp Glu Asp Arg Ser  Gly Gly Asn Phe Cys  Arg Ser Cys 
    1205                 1210                 1215             


Pro Ser  Lys Leu His Asn Tyr  Ser Thr Thr Val Thr  Gly Gln Asn 
    1220                 1225                 1230             


Ser Gly  Arg Gln Ala Cys Ile  Arg Cys Glu Ala Cys  Lys Lys Ala 
    1235                 1240                 1245             


Gly Asn  Leu Tyr Asp Ile Ser  Glu Asp Asn Ser Leu  Gln Glu Leu 
    1250                 1255                 1260             


Asp Gln  Pro Ala Ala Pro Val  Ala Val Thr Ser Asn  Ala Ser Thr 
    1265                 1270                 1275             


Thr Lys  Tyr Pro Gln Ser Pro  Thr Asn Ser Lys Ala  Gln Lys Lys 
    1280                 1285                 1290             


Asn Arg  Asn Lys Leu Arg Arg  Gln His Ser Tyr Asp  Thr Phe Val 
    1295                 1300                 1305             


Asp Leu  Gln Lys Glu Glu Ala  Ala Leu Ala Pro Arg  Ser Val Ser 
    1310                 1315                 1320             


Leu Lys  Asp Lys Gly Arg Phe  Met Asp Gly Ser Pro  Tyr Ala His 
    1325                 1330                 1335             


Met Phe  Glu Met Ser Ala Gly  Glu Ser Thr Phe Ala  Asn Asn Lys 
    1340                 1345                 1350             


Ser Ser  Val Pro Thr Ala Gly  His His His His Asn  Asn Pro Gly 
    1355                 1360                 1365             


Gly Gly  Tyr Met Leu Ser Lys  Ser Leu Tyr Pro Asp  Arg Val Thr 
    1370                 1375                 1380             


Gln Asn  Pro Phe Ile Pro Thr  Phe Gly Asp Asp Gln  Cys Leu Leu 
    1385                 1390                 1395             


His Gly  Ser Lys Ser Tyr Phe  Phe Arg Gln Pro Thr  Val Ala Gly 
    1400                 1405                 1410             


Ala Ser  Lys Ala Arg Pro Asp  Phe Arg Ala Leu Val  Thr Asn Lys 
    1415                 1420                 1425             


Pro Val  Val Ser Ala Leu His  Gly Ala Val Pro Ala  Arg Phe Gln 
    1430                 1435                 1440             


Lys Asp  Ile Cys Ile Gly Asn  Gln Ser Asn Pro Cys  Val Pro Asn 
    1445                 1450                 1455             


Asn Lys  Asn Pro Arg Ala Phe  Asn Gly Ser Ser Asn  Gly His Val 
    1460                 1465                 1470             


Tyr Glu  Lys Leu Ser Ser Ile  Glu Ser Asp Val 
    1475                 1480                 


<210>  285
<211>  1233
<212>  PRT
<213>  Homo sapiens

<400>  285

Met Gly Gly Ala Leu Gly Pro Ala Leu Leu Leu Thr Ser Leu Phe Gly 
1               5                   10                  15      


Ala Trp Ala Gly Leu Gly Pro Gly Gln Gly Glu Gln Gly Met Thr Val 
            20                  25                  30          


Ala Val Val Phe Ser Ser Ser Gly Pro Pro Gln Ala Gln Phe Arg Ala 
        35                  40                  45              


Arg Leu Thr Pro Gln Ser Phe Leu Asp Leu Pro Leu Glu Ile Gln Pro 
    50                  55                  60                  


Leu Thr Val Gly Val Asn Thr Thr Asn Pro Ser Ser Leu Leu Thr Gln 
65                  70                  75                  80  


Ile Cys Gly Leu Leu Gly Ala Ala His Val His Gly Ile Val Phe Glu 
                85                  90                  95      


Asp Asn Val Asp Thr Glu Ala Val Ala Gln Ile Leu Asp Phe Ile Ser 
            100                 105                 110         


Ser Gln Thr His Val Pro Ile Leu Ser Ile Ser Gly Gly Ser Ala Val 
        115                 120                 125             


Val Leu Thr Pro Lys Glu Pro Gly Ser Ala Phe Leu Gln Leu Gly Val 
    130                 135                 140                 


Ser Leu Glu Gln Gln Leu Gln Val Leu Phe Lys Val Leu Glu Glu Tyr 
145                 150                 155                 160 


Asp Trp Ser Ala Phe Ala Val Ile Thr Ser Leu His Pro Gly His Ala 
                165                 170                 175     


Leu Phe Leu Glu Gly Val Arg Ala Val Ala Asp Ala Ser His Val Ser 
            180                 185                 190         


Trp Arg Leu Leu Asp Val Val Thr Leu Glu Leu Gly Pro Gly Gly Pro 
        195                 200                 205             


Arg Ala Arg Thr Gln Arg Leu Leu Arg Gln Leu Asp Ala Pro Val Phe 
    210                 215                 220                 


Val Ala Tyr Cys Ser Arg Glu Glu Ala Glu Val Leu Phe Ala Glu Ala 
225                 230                 235                 240 


Ala Gln Ala Gly Leu Val Gly Pro Gly His Val Trp Leu Val Pro Asn 
                245                 250                 255     


Leu Ala Leu Gly Ser Thr Asp Ala Pro Pro Ala Thr Phe Pro Val Gly 
            260                 265                 270         


Leu Ile Ser Val Val Thr Glu Ser Trp Arg Leu Ser Leu Arg Gln Lys 
        275                 280                 285             


Val Arg Asp Gly Val Ala Ile Leu Ala Leu Gly Ala His Ser Tyr Trp 
    290                 295                 300                 


Arg Gln His Gly Thr Leu Pro Ala Pro Ala Gly Asp Cys Arg Val His 
305                 310                 315                 320 


Pro Gly Pro Val Ser Pro Ala Arg Glu Ala Phe Tyr Arg His Leu Leu 
                325                 330                 335     


Asn Val Thr Trp Glu Gly Arg Asp Phe Ser Phe Ser Pro Gly Gly Tyr 
            340                 345                 350         


Leu Val Gln Pro Thr Met Val Val Ile Ala Leu Asn Arg His Arg Leu 
        355                 360                 365             


Trp Glu Met Val Gly Arg Trp Glu His Gly Val Leu Tyr Met Lys Tyr 
    370                 375                 380                 


Pro Val Trp Pro Arg Tyr Ser Ala Ser Leu Gln Pro Val Val Asp Ser 
385                 390                 395                 400 


Arg His Leu Thr Val Ala Thr Leu Glu Glu Arg Pro Phe Val Ile Val 
                405                 410                 415     


Glu Ser Pro Asp Pro Gly Thr Gly Gly Cys Val Pro Asn Thr Val Pro 
            420                 425                 430         


Cys Arg Arg Gln Ser Asn His Thr Phe Ser Ser Gly Asp Val Ala Pro 
        435                 440                 445             


Tyr Thr Lys Leu Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu Lys Lys 
    450                 455                 460                 


Leu Ala Arg Val Val Lys Phe Ser Tyr Asp Leu Tyr Leu Val Thr Asn 
465                 470                 475                 480 


Gly Lys His Gly Lys Arg Val Arg Gly Val Trp Asn Gly Met Ile Gly 
                485                 490                 495     


Glu Val Tyr Tyr Lys Arg Ala Asp Met Ala Ile Gly Ser Leu Thr Ile 
            500                 505                 510         


Asn Glu Glu Arg Ser Glu Ile Val Asp Phe Ser Val Pro Phe Val Glu 
        515                 520                 525             


Thr Gly Ile Ser Val Met Val Ala Arg Ser Asn Gly Thr Val Ser Pro 
    530                 535                 540                 


Ser Ala Phe Leu Glu Pro Tyr Ser Pro Ala Val Trp Val Met Met Phe 
545                 550                 555                 560 


Val Met Cys Leu Thr Val Val Ala Ile Thr Val Phe Met Phe Glu Tyr 
                565                 570                 575     


Phe Ser Pro Val Ser Tyr Asn Gln Asn Leu Thr Arg Gly Lys Lys Ser 
            580                 585                 590         


Gly Gly Pro Ala Phe Thr Ile Gly Lys Ser Val Trp Leu Leu Trp Ala 
        595                 600                 605             


Leu Val Phe Asn Asn Ser Val Pro Ile Glu Asn Pro Arg Gly Thr Thr 
    610                 615                 620                 


Ser Lys Ile Met Val Leu Val Trp Ala Phe Phe Ala Val Ile Phe Leu 
625                 630                 635                 640 


Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu Gln Tyr 
                645                 650                 655     


Ile Asp Thr Val Ser Gly Leu Ser Asp Lys Lys Phe Gln Arg Pro Gln 
            660                 665                 670         


Asp Gln Tyr Pro Pro Phe Arg Phe Gly Thr Val Pro Asn Gly Ser Thr 
        675                 680                 685             


Glu Arg Asn Ile Arg Ser Asn Tyr Arg Asp Met His Thr His Met Val 
    690                 695                 700                 


Lys Phe Asn Gln Arg Ser Val Glu Asp Ala Leu Thr Ser Leu Lys Met 
705                 710                 715                 720 


Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn Tyr Met 
                725                 730                 735     


Ala Gly Lys Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser Gly Lys 
            740                 745                 750         


Val Phe Ala Thr Thr Gly Tyr Gly Ile Ala Met Gln Lys Asp Ser His 
        755                 760                 765             


Trp Lys Arg Ala Ile Asp Leu Ala Leu Leu Gln Phe Leu Gly Asp Gly 
    770                 775                 780                 


Glu Thr Gln Lys Leu Glu Thr Val Trp Leu Ser Gly Ile Cys Gln Asn 
785                 790                 795                 800 


Glu Lys Asn Glu Val Met Ser Ser Lys Leu Asp Ile Asp Asn Met Ala 
                805                 810                 815     


Gly Val Phe Tyr Met Leu Leu Val Ala Met Gly Leu Ala Leu Leu Val 
            820                 825                 830         


Phe Ala Trp Glu His Leu Val Tyr Trp Lys Leu Arg His Ser Val Pro 
        835                 840                 845             


Asn Ser Ser Gln Leu Asp Phe Leu Leu Ala Phe Ser Arg Gly Ile Tyr 
    850                 855                 860                 


Ser Cys Phe Ser Gly Val Gln Ser Leu Ala Ser Pro Pro Arg Gln Ala 
865                 870                 875                 880 


Ser Pro Asp Leu Thr Ala Ser Ser Ala Gln Ala Ser Val Leu Lys Met 
                885                 890                 895     


Leu Gln Ala Ala Arg Asp Met Val Thr Thr Ala Gly Val Ser Ser Ser 
            900                 905                 910         


Leu Asp Arg Ala Thr Arg Thr Ile Glu Asn Trp Gly Gly Gly Arg Arg 
        915                 920                 925             


Ala Pro Pro Pro Ser Pro Cys Pro Thr Pro Arg Ser Gly Pro Ser Pro 
    930                 935                 940                 


Cys Leu Pro Thr Pro Asp Pro Pro Pro Glu Pro Ser Pro Thr Gly Trp 
945                 950                 955                 960 


Gly Pro Pro Asp Gly Gly Arg Ala Ala Leu Val Arg Arg Ala Pro Gln 
                965                 970                 975     


Pro Pro Gly Arg Pro Pro Thr Pro Gly Pro Pro Leu Ser Asp Val Ser 
            980                 985                 990         


Arg Val Ser Arg Arg Pro Ala Trp  Glu Ala Arg Trp Pro  Val Arg Thr 
        995                 1000                 1005             


Gly His  Cys Gly Arg His Leu  Ser Ala Ser Glu Arg  Pro Leu Ser 
    1010                 1015                 1020             


Pro Ala  Arg Cys His Tyr Ser  Ser Phe Pro Arg Ala  Asp Arg Ser 
    1025                 1030                 1035             


Gly Arg  Pro Phe Leu Pro Leu  Phe Pro Glu Leu Glu  Asp Leu Pro 
    1040                 1045                 1050             


Leu Leu  Gly Pro Glu Gln Leu  Ala Arg Arg Glu Ala  Leu Leu His 
    1055                 1060                 1065             


Ala Ala  Trp Ala Arg Gly Ser  Arg Pro Arg His Ala  Ser Leu Pro 
    1070                 1075                 1080             


Ser Ser  Val Ala Glu Ala Phe  Ala Arg Pro Ser Ser  Leu Pro Ala 
    1085                 1090                 1095             


Gly Cys  Thr Gly Pro Ala Cys  Ala Arg Pro Asp Gly  His Ser Ala 
    1100                 1105                 1110             


Cys Arg  Arg Leu Ala Gln Ala  Gln Ser Met Cys Leu  Pro Ile Tyr 
    1115                 1120                 1125             


Arg Glu  Ala Cys Gln Glu Gly  Glu Gln Ala Gly Ala  Pro Ala Trp 
    1130                 1135                 1140             


Gln His  Arg Gln His Val Cys  Leu His Ala His Ala  His Leu Pro 
    1145                 1150                 1155             


Phe Cys  Trp Gly Ala Val Cys  Pro His Leu Pro Pro  Cys Ala Ser 
    1160                 1165                 1170             


His Gly  Ser Trp Leu Ser Gly  Ala Trp Gly Pro Leu  Gly His Arg 
    1175                 1180                 1185             


Gly Arg  Thr Leu Gly Leu Gly  Thr Gly Tyr Arg Asp  Ser Gly Gly 
    1190                 1195                 1200             


Leu Asp  Glu Ile Ser Arg Val  Ala Arg Gly Thr Gln  Gly Phe Pro 
    1205                 1210                 1215             


Gly Pro  Cys Thr Trp Arg Arg  Ile Ser Ser Leu Glu  Ser Glu Val 
    1220                 1225                 1230             


<210>  286
<211>  1336
<212>  PRT
<213>  Homo sapiens

<400>  286

Met Arg Gly Ala Gly Gly Pro Arg Gly Pro Arg Gly Pro Ala Lys Met 
1               5                   10                  15      


Leu Leu Leu Leu Ala Leu Ala Cys Ala Ser Pro Phe Pro Glu Glu Ala 
            20                  25                  30          


Pro Gly Pro Gly Gly Ala Gly Gly Pro Gly Gly Gly Leu Gly Gly Ala 
        35                  40                  45              


Arg Pro Leu Asn Val Ala Leu Val Phe Ser Gly Pro Ala Tyr Ala Ala 
    50                  55                  60                  


Glu Ala Ala Arg Leu Gly Pro Ala Val Ala Ala Ala Val Arg Ser Pro 
65                  70                  75                  80  


Gly Leu Asp Val Arg Pro Val Ala Leu Val Leu Asn Gly Ser Asp Pro 
                85                  90                  95      


Arg Ser Leu Val Leu Gln Leu Cys Asp Leu Leu Ser Gly Leu Arg Val 
            100                 105                 110         


His Gly Val Val Phe Glu Asp Asp Ser Arg Ala Pro Ala Val Ala Pro 
        115                 120                 125             


Ile Leu Asp Phe Leu Ser Ala Gln Thr Ser Leu Pro Ile Val Ala Val 
    130                 135                 140                 


His Gly Gly Ala Ala Leu Val Leu Thr Pro Lys Glu Lys Gly Ser Thr 
145                 150                 155                 160 


Phe Leu Gln Leu Gly Ser Ser Thr Glu Gln Gln Leu Gln Val Ile Phe 
                165                 170                 175     


Glu Val Leu Glu Glu Tyr Asp Trp Thr Ser Phe Val Ala Val Thr Thr 
            180                 185                 190         


Arg Ala Pro Gly His Arg Ala Phe Leu Ser Tyr Ile Glu Val Leu Thr 
        195                 200                 205             


Asp Gly Ser Leu Val Gly Trp Glu His Arg Gly Ala Leu Thr Leu Asp 
    210                 215                 220                 


Pro Gly Ala Gly Glu Ala Val Leu Ser Ala Gln Leu Arg Ser Val Ser 
225                 230                 235                 240 


Ala Gln Ile Arg Leu Leu Phe Cys Ala Arg Glu Glu Ala Glu Pro Val 
                245                 250                 255     


Phe Arg Ala Ala Glu Glu Ala Gly Leu Thr Gly Ser Gly Tyr Val Trp 
            260                 265                 270         


Phe Met Val Gly Pro Gln Leu Ala Gly Gly Gly Gly Ser Gly Ala Pro 
        275                 280                 285             


Gly Glu Pro Pro Leu Leu Pro Gly Gly Ala Pro Leu Pro Ala Gly Leu 
    290                 295                 300                 


Phe Ala Val Arg Ser Ala Gly Trp Arg Asp Asp Leu Ala Arg Arg Val 
305                 310                 315                 320 


Ala Ala Gly Val Ala Val Val Ala Arg Gly Ala Gln Ala Leu Leu Arg 
                325                 330                 335     


Asp Tyr Gly Phe Leu Pro Glu Leu Gly His Asp Cys Arg Ala Gln Asn 
            340                 345                 350         


Arg Thr His Arg Gly Glu Ser Leu His Arg Tyr Phe Met Asn Ile Thr 
        355                 360                 365             


Trp Asp Asn Arg Asp Tyr Ser Phe Asn Glu Asp Gly Phe Leu Val Asn 
    370                 375                 380                 


Pro Ser Leu Val Val Ile Ser Leu Thr Arg Asp Arg Thr Trp Glu Val 
385                 390                 395                 400 


Val Gly Ser Trp Glu Gln Gln Thr Leu Arg Leu Lys Tyr Pro Leu Trp 
                405                 410                 415     


Ser Arg Tyr Gly Arg Phe Leu Gln Pro Val Asp Asp Thr Gln His Leu 
            420                 425                 430         


Thr Val Ala Thr Leu Glu Glu Arg Pro Phe Val Ile Val Glu Pro Ala 
        435                 440                 445             


Asp Pro Ile Ser Gly Thr Cys Ile Arg Asp Ser Val Pro Cys Arg Ser 
    450                 455                 460                 


Gln Leu Asn Arg Thr His Ser Pro Pro Pro Asp Ala Pro Arg Pro Glu 
465                 470                 475                 480 


Lys Arg Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu Lys Arg Leu Ala 
                485                 490                 495     


His Thr Ile Gly Phe Ser Tyr Asp Leu Tyr Leu Val Thr Asn Gly Lys 
            500                 505                 510         


His Gly Lys Lys Ile Asp Gly Val Trp Asn Gly Met Ile Gly Glu Val 
        515                 520                 525             


Phe Tyr Gln Arg Ala Asp Met Ala Ile Gly Ser Leu Thr Ile Asn Glu 
    530                 535                 540                 


Glu Arg Ser Glu Ile Val Asp Phe Ser Val Pro Phe Val Glu Thr Gly 
545                 550                 555                 560 


Ile Ser Val Met Val Ala Arg Ser Asn Gly Thr Val Ser Pro Ser Ala 
                565                 570                 575     


Phe Leu Glu Pro Tyr Ser Pro Ala Val Trp Val Met Met Phe Val Met 
            580                 585                 590         


Cys Leu Thr Val Val Ala Val Thr Val Phe Ile Phe Glu Tyr Leu Ser 
        595                 600                 605             


Pro Val Gly Tyr Asn Arg Ser Leu Ala Thr Gly Lys Arg Pro Gly Gly 
    610                 615                 620                 


Ser Thr Phe Thr Ile Gly Lys Ser Ile Trp Leu Leu Trp Ala Leu Val 
625                 630                 635                 640 


Phe Asn Asn Ser Val Pro Val Glu Asn Pro Arg Gly Thr Thr Ser Lys 
                645                 650                 655     


Ile Met Val Leu Val Trp Ala Phe Phe Ala Val Ile Phe Leu Ala Ser 
            660                 665                 670         


Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu Glu Tyr Val Asp 
        675                 680                 685             


Thr Val Ser Gly Leu Ser Asp Arg Lys Phe Gln Arg Pro Gln Glu Gln 
    690                 695                 700                 


Tyr Pro Pro Leu Lys Phe Gly Thr Val Pro Asn Gly Ser Thr Glu Lys 
705                 710                 715                 720 


Asn Ile Arg Ser Asn Tyr Pro Asp Met His Ser Tyr Met Val Arg Tyr 
                725                 730                 735     


Asn Gln Pro Arg Val Glu Glu Ala Leu Thr Gln Leu Lys Ala Gly Lys 
            740                 745                 750         


Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn Tyr Met Ala Arg 
        755                 760                 765             


Lys Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser Gly Lys Val Phe 
    770                 775                 780                 


Ala Thr Thr Gly Tyr Gly Ile Ala Leu His Lys Gly Ser Arg Trp Lys 
785                 790                 795                 800 


Arg Pro Ile Asp Leu Ala Leu Leu Gln Phe Leu Gly Asp Asp Glu Ile 
                805                 810                 815     


Glu Met Leu Glu Arg Leu Trp Leu Ser Gly Ile Cys His Asn Asp Lys 
            820                 825                 830         


Ile Glu Val Met Ser Ser Lys Leu Asp Ile Asp Asn Met Ala Gly Val 
        835                 840                 845             


Phe Tyr Met Leu Leu Val Ala Met Gly Leu Ser Leu Leu Val Phe Ala 
    850                 855                 860                 


Trp Glu His Leu Val Tyr Trp Arg Leu Arg His Cys Leu Gly Pro Thr 
865                 870                 875                 880 


His Arg Met Asp Phe Leu Leu Ala Phe Ser Arg Gly Met Tyr Ser Cys 
                885                 890                 895     


Cys Ser Ala Glu Ala Ala Pro Pro Pro Ala Lys Pro Pro Pro Pro Pro 
            900                 905                 910         


Gln Pro Leu Pro Ser Pro Ala Tyr Pro Ala Pro Arg Pro Ala Pro Gly 
        915                 920                 925             


Pro Ala Pro Phe Val Pro Arg Glu Arg Ala Ser Val Asp Arg Trp Arg 
    930                 935                 940                 


Arg Thr Lys Gly Ala Gly Pro Pro Gly Gly Ala Gly Leu Ala Asp Gly 
945                 950                 955                 960 


Phe His Arg Tyr Tyr Gly Pro Ile Glu Pro Gln Gly Leu Gly Leu Gly 
                965                 970                 975     


Leu Gly Glu Ala Arg Ala Ala Pro Arg Gly Ala Ala Gly Arg Pro Leu 
            980                 985                 990         


Ser Pro Pro Ala Ala Gln Pro Pro  Gln Lys Pro Pro Pro  Ser Tyr Phe 
        995                 1000                 1005             


Ala Ile  Val Arg Asp Lys Glu  Pro Ala Glu Pro Pro  Ala Gly Ala 
    1010                 1015                 1020             


Phe Pro  Gly Phe Pro Ser Pro  Pro Ala Pro Pro Ala  Ala Ala Ala 
    1025                 1030                 1035             


Thr Ala  Val Gly Pro Pro Leu  Cys Arg Leu Ala Phe  Glu Asp Glu 
    1040                 1045                 1050             


Ser Pro  Pro Ala Pro Ala Arg  Trp Pro Arg Ser Asp  Pro Glu Ser 
    1055                 1060                 1065             


Gln Pro  Leu Leu Gly Pro Gly  Ala Gly Gly Ala Gly  Gly Thr Gly 
    1070                 1075                 1080             


Gly Ala  Gly Gly Gly Ala Pro  Ala Ala Pro Pro Pro  Cys Arg Ala 
    1085                 1090                 1095             


Ala Pro  Pro Pro Cys Pro Tyr  Leu Asp Leu Glu Pro  Ser Pro Ser 
    1100                 1105                 1110             


Asp Ser  Glu Asp Ser Glu Ser  Leu Gly Gly Ala Ser  Leu Gly Gly 
    1115                 1120                 1125             


Leu Glu  Pro Trp Trp Phe Ala  Asp Phe Pro Tyr Pro  Tyr Ala Glu 
    1130                 1135                 1140             


Arg Leu  Gly Pro Pro Pro Gly  Arg Tyr Trp Ser Val  Asp Lys Leu 
    1145                 1150                 1155             


Gly Gly  Trp Arg Ala Gly Ser  Trp Asp Tyr Leu Pro  Pro Arg Ser 
    1160                 1165                 1170             


Gly Pro  Ala Ala Trp His Cys  Arg His Cys Ala Ser  Leu Glu Leu 
    1175                 1180                 1185             


Leu Pro  Pro Pro Arg His Leu  Ser Cys Ser His Asp  Gly Leu Asp 
    1190                 1195                 1200             


Gly Gly  Trp Trp Ala Pro Pro  Pro Pro Pro Trp Ala  Ala Gly Pro 
    1205                 1210                 1215             


Leu Pro  Arg Arg Arg Ala Arg  Cys Gly Cys Pro Arg  Ser His Pro 
    1220                 1225                 1230             


His Arg  Pro Arg Ala Ser His  Arg Thr Pro Ala Ala  Ala Ala Pro 
    1235                 1240                 1245             


His His  His Arg His Arg Arg  Ala Ala Gly Gly Trp  Asp Leu Pro 
    1250                 1255                 1260             


Pro Pro  Ala Pro Thr Ser Arg  Ser Leu Glu Asp Leu  Ser Ser Cys 
    1265                 1270                 1275             


Pro Arg  Ala Ala Pro Ala Arg  Arg Leu Thr Gly Pro  Ser Arg His 
    1280                 1285                 1290             


Ala Arg  Arg Cys Pro His Ala  Ala His Trp Gly Pro  Pro Leu Pro 
    1295                 1300                 1305             


Thr Ala  Ser His Arg Arg His  Arg Gly Gly Asp Leu  Gly Thr Arg 
    1310                 1315                 1320             


Arg Gly  Ser Ala His Phe Ser  Ser Leu Glu Ser Glu  Val 
    1325                 1330                 1335     


<210>  287
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  287

Met Ser His Glu Lys Ser Phe Leu Val Ser Gly Asp Asn Tyr Pro Pro 
1               5                   10                  15      


Pro Asn Pro Gly Tyr Pro Gly Gly Pro Gln Pro Pro Met Pro Pro Tyr 
            20                  25                  30          


Ala Gln Pro Pro Tyr Pro Gly Ala Pro Tyr Pro Gln Pro Pro Phe Gln 
        35                  40                  45              


Pro Ser Pro Tyr Gly Gln Pro Gly Tyr Pro His Gly Pro Ser Pro Tyr 
    50                  55                  60                  


Pro Gln Gly Gly Tyr Pro Gln Gly Pro Tyr Pro Gln Gly Gly Tyr Pro 
65                  70                  75                  80  


Gln Gly Pro Tyr Pro Gln Glu Gly Tyr Pro Gln Gly Pro Tyr Pro Gln 
                85                  90                  95      


Gly Gly Tyr Pro Gln Gly Pro Tyr Pro Gln Ser Pro Phe Pro Pro Asn 
            100                 105                 110         


Pro Tyr Gly Gln Pro Gln Val Phe Pro Gly Gln Asp Pro Asp Ser Pro 
        115                 120                 125             


Gln His Gly Asn Tyr Gln Glu Glu Gly Pro Pro Ser Tyr Tyr Asp Asn 
    130                 135                 140                 


Gln Asp Phe Pro Ala Thr Asn Trp Asp Asp Lys Ser Ile Arg Gln Ala 
145                 150                 155                 160 


Phe Ile Arg Lys Val Phe Leu Val Leu Thr Leu Gln Leu Ser Val Thr 
                165                 170                 175     


Leu Ser Thr Val Ser Val Phe Thr Phe Val Ala Glu Val Lys Gly Phe 
            180                 185                 190         


Val Arg Glu Asn Val Trp Thr Tyr Tyr Val Ser Tyr Ala Val Phe Phe 
        195                 200                 205             


Ile Ser Leu Ile Val Leu Ser Cys Cys Gly Asp Phe Arg Arg Lys His 
    210                 215                 220                 


Pro Trp Asn Leu Val Ala Leu Ser Val Leu Thr Ala Ser Leu Ser Tyr 
225                 230                 235                 240 


Met Val Gly Met Ile Ala Ser Phe Tyr Asn Thr Glu Ala Val Ile Met 
                245                 250                 255     


Ala Val Gly Ile Thr Thr Ala Val Cys Phe Thr Val Val Ile Phe Ser 
            260                 265                 270         


Met Gln Thr Arg Tyr Asp Phe Thr Ser Cys Met Gly Val Leu Leu Val 
        275                 280                 285             


Ser Met Val Val Leu Phe Ile Phe Ala Ile Leu Cys Ile Phe Ile Arg 
    290                 295                 300                 


Asn Arg Ile Leu Glu Ile Val Tyr Ala Ser Leu Gly Ala Leu Leu Phe 
305                 310                 315                 320 


Thr Cys Phe Leu Ala Val Asp Thr Gln Leu Leu Leu Gly Asn Lys Gln 
                325                 330                 335     


Leu Ser Leu Ser Pro Glu Glu Tyr Val Phe Ala Ala Leu Asn Leu Tyr 
            340                 345                 350         


Thr Asp Ile Ile Asn Ile Phe Leu Tyr Ile Leu Thr Ile Ile Gly Arg 
        355                 360                 365             


Ala Lys Glu 
    370     


<210>  288
<211>  1194
<212>  PRT
<213>  Homo sapiens

<400>  288

Met Val Gly Leu Leu Leu Phe Phe Phe Pro Ala Ile Phe Leu Glu Val 
1               5                   10                  15      


Ser Leu Leu Pro Arg Ser Pro Gly Arg Lys Val Leu Leu Ala Gly Ala 
            20                  25                  30          


Ser Ser Gln Arg Ser Val Ala Arg Met Asp Gly Asp Val Ile Ile Gly 
        35                  40                  45              


Ala Leu Phe Ser Val His His Gln Pro Pro Ala Glu Lys Val Pro Glu 
    50                  55                  60                  


Arg Lys Cys Gly Glu Ile Arg Glu Gln Tyr Gly Ile Gln Arg Val Glu 
65                  70                  75                  80  


Ala Met Phe His Thr Leu Asp Lys Ile Asn Ala Asp Pro Val Leu Leu 
                85                  90                  95      


Pro Asn Ile Thr Leu Gly Ser Glu Ile Arg Asp Ser Cys Trp His Ser 
            100                 105                 110         


Ser Val Ala Leu Glu Gln Ser Ile Glu Phe Ile Arg Asp Ser Leu Ile 
        115                 120                 125             


Ser Ile Arg Asp Glu Lys Asp Gly Ile Asn Arg Cys Leu Pro Asp Gly 
    130                 135                 140                 


Gln Ser Leu Pro Pro Gly Arg Thr Lys Lys Pro Ile Ala Gly Val Ile 
145                 150                 155                 160 


Gly Pro Gly Ser Ser Ser Val Ala Ile Gln Val Gln Asn Leu Leu Gln 
                165                 170                 175     


Leu Phe Asp Ile Pro Gln Ile Ala Tyr Ser Ala Thr Ser Ile Asp Leu 
            180                 185                 190         


Ser Asp Lys Thr Leu Tyr Lys Tyr Phe Leu Arg Val Val Pro Ser Asp 
        195                 200                 205             


Thr Leu Gln Ala Arg Ala Met Leu Asp Ile Val Lys Arg Tyr Asn Trp 
    210                 215                 220                 


Thr Tyr Val Ser Ala Val His Thr Glu Gly Asn Tyr Gly Glu Ser Gly 
225                 230                 235                 240 


Met Asp Ala Phe Lys Glu Leu Ala Ala Gln Glu Gly Leu Cys Ile Ala 
                245                 250                 255     


His Ser Asp Lys Ile Tyr Ser Asn Ala Gly Glu Lys Ser Phe Asp Arg 
            260                 265                 270         


Leu Leu Arg Lys Leu Arg Glu Arg Leu Pro Lys Ala Arg Val Val Val 
        275                 280                 285             


Cys Phe Cys Glu Gly Met Thr Val Arg Gly Leu Leu Ser Ala Met Arg 
    290                 295                 300                 


Arg Leu Gly Val Val Gly Glu Phe Ser Leu Ile Gly Ser Asp Gly Trp 
305                 310                 315                 320 


Ala Asp Arg Asp Glu Val Ile Glu Gly Tyr Glu Val Glu Ala Asn Gly 
                325                 330                 335     


Gly Ile Thr Ile Lys Leu Gln Ser Pro Glu Val Arg Ser Phe Asp Asp 
            340                 345                 350         


Tyr Phe Leu Lys Leu Arg Leu Asp Thr Asn Thr Arg Asn Pro Trp Phe 
        355                 360                 365             


Pro Glu Phe Trp Gln His Arg Phe Gln Cys Arg Leu Pro Gly His Leu 
    370                 375                 380                 


Leu Glu Asn Pro Asn Phe Lys Arg Ile Cys Thr Gly Asn Glu Ser Leu 
385                 390                 395                 400 


Glu Glu Asn Tyr Val Gln Asp Ser Lys Met Gly Phe Val Ile Asn Ala 
                405                 410                 415     


Ile Tyr Ala Met Ala His Gly Leu Gln Asn Met His His Ala Leu Cys 
            420                 425                 430         


Pro Gly His Val Gly Leu Cys Asp Ala Met Lys Pro Ile Asp Gly Ser 
        435                 440                 445             


Lys Leu Leu Asp Phe Leu Ile Lys Ser Ser Phe Ile Gly Val Ser Gly 
    450                 455                 460                 


Glu Glu Val Trp Phe Asp Glu Lys Gly Asp Ala Pro Gly Arg Tyr Asp 
465                 470                 475                 480 


Ile Met Asn Leu Gln Tyr Thr Glu Ala Asn Arg Tyr Asp Tyr Val His 
                485                 490                 495     


Val Gly Thr Trp His Glu Gly Val Leu Asn Ile Asp Asp Tyr Lys Ile 
            500                 505                 510         


Gln Met Asn Lys Ser Gly Val Val Arg Ser Val Cys Ser Glu Pro Cys 
        515                 520                 525             


Leu Lys Gly Gln Ile Lys Val Ile Arg Lys Gly Glu Val Ser Cys Cys 
    530                 535                 540                 


Trp Ile Cys Thr Ala Cys Lys Glu Asn Glu Tyr Val Gln Asp Glu Phe 
545                 550                 555                 560 


Thr Cys Lys Ala Cys Asp Leu Gly Trp Trp Pro Asn Ala Asp Leu Thr 
                565                 570                 575     


Gly Cys Glu Pro Ile Pro Val Arg Tyr Leu Glu Trp Ser Asn Ile Glu 
            580                 585                 590         


Ser Ile Ile Ala Ile Ala Phe Ser Cys Leu Gly Ile Leu Val Thr Leu 
        595                 600                 605             


Phe Val Thr Leu Ile Phe Val Leu Tyr Arg Asp Thr Pro Val Val Lys 
    610                 615                 620                 


Ser Ser Ser Arg Glu Leu Cys Tyr Ile Ile Leu Ala Gly Ile Phe Leu 
625                 630                 635                 640 


Gly Tyr Val Cys Pro Phe Thr Leu Ile Ala Lys Pro Thr Thr Thr Ser 
                645                 650                 655     


Cys Tyr Leu Gln Arg Leu Leu Val Gly Leu Ser Ser Ala Met Cys Tyr 
            660                 665                 670         


Ser Ala Leu Val Thr Lys Thr Asn Arg Ile Ala Arg Ile Leu Ala Gly 
        675                 680                 685             


Ser Lys Lys Lys Ile Cys Thr Arg Lys Pro Arg Phe Met Ser Ala Trp 
    690                 695                 700                 


Ala Gln Val Ile Ile Ala Ser Ile Leu Ile Ser Val Gln Leu Thr Leu 
705                 710                 715                 720 


Val Val Thr Leu Ile Ile Met Glu Pro Pro Met Pro Ile Leu Ser Tyr 
                725                 730                 735     


Pro Ser Ile Lys Glu Val Tyr Leu Ile Cys Asn Thr Ser Asn Leu Gly 
            740                 745                 750         


Val Val Ala Pro Leu Gly Tyr Asn Gly Leu Leu Ile Met Ser Cys Thr 
        755                 760                 765             


Tyr Tyr Ala Phe Lys Thr Arg Asn Val Pro Ala Asn Phe Asn Glu Ala 
    770                 775                 780                 


Lys Tyr Ile Ala Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala 
785                 790                 795                 800 


Phe Val Pro Ile Tyr Phe Gly Ser Asn Tyr Lys Ile Ile Thr Thr Cys 
                805                 810                 815     


Phe Ala Val Ser Leu Ser Val Thr Val Ala Leu Gly Cys Met Phe Thr 
            820                 825                 830         


Pro Lys Met Tyr Ile Ile Ile Ala Lys Pro Glu Arg Asn Val Arg Ser 
        835                 840                 845             


Ala Phe Thr Thr Ser Asp Val Val Arg Met His Val Gly Asp Gly Lys 
    850                 855                 860                 


Leu Pro Cys Arg Ser Asn Thr Phe Leu Asn Ile Phe Arg Arg Lys Lys 
865                 870                 875                 880 


Ala Gly Ala Gly Asn Ala Asn Ser Asn Gly Lys Ser Val Ser Trp Ser 
                885                 890                 895     


Glu Pro Gly Gly Gly Gln Val Pro Lys Gly Gln His Met Trp His Arg 
            900                 905                 910         


Leu Ser Val His Val Lys Thr Asn Glu Thr Ala Cys Asn Gln Thr Ala 
        915                 920                 925             


Val Ile Lys Pro Leu Thr Lys Ser Tyr Gln Gly Ser Gly Lys Ser Leu 
    930                 935                 940                 


Thr Phe Ser Asp Thr Ser Thr Lys Thr Leu Tyr Asn Val Glu Glu Glu 
945                 950                 955                 960 


Glu Asp Ala Gln Pro Ile Arg Phe Ser Pro Pro Gly Ser Pro Ser Met 
                965                 970                 975     


Val Val His Arg Arg Val Pro Ser Ala Ala Thr Thr Pro Pro Leu Pro 
            980                 985                 990         


Ser His Leu Thr Ala Glu Glu Thr  Pro Leu Phe Leu Ala  Glu Pro Ala 
        995                 1000                 1005             


Leu Pro  Lys Gly Leu Pro Pro  Pro Leu Gln Gln Gln  Gln Gln Pro 
    1010                 1015                 1020             


Pro Pro  Gln Gln Lys Ser Leu  Met Asp Gln Leu Gln  Gly Val Val 
    1025                 1030                 1035             


Ser Asn  Phe Ser Thr Ala Ile  Pro Asp Phe His Ala  Val Leu Ala 
    1040                 1045                 1050             


Gly Pro  Gly Gly Pro Gly Asn  Gly Leu Arg Ser Leu  Tyr Pro Pro 
    1055                 1060                 1065             


Pro Pro  Pro Pro Gln His Leu  Gln Met Leu Pro Leu  Gln Leu Ser 
    1070                 1075                 1080             


Thr Phe  Gly Glu Glu Leu Val  Ser Pro Pro Ala Asp  Asp Asp Asp 
    1085                 1090                 1095             


Asp Ser  Glu Arg Phe Lys Leu  Leu Gln Glu Tyr Val  Tyr Glu His 
    1100                 1105                 1110             


Glu Arg  Glu Gly Asn Thr Glu  Glu Asp Glu Leu Glu  Glu Glu Glu 
    1115                 1120                 1125             


Glu Asp  Leu Gln Ala Ala Ser  Lys Leu Thr Pro Asp  Asp Ser Pro 
    1130                 1135                 1140             


Ala Leu  Thr Pro Pro Ser Pro  Phe Arg Asp Ser Val  Ala Ser Gly 
    1145                 1150                 1155             


Ser Ser  Val Pro Ser Ser Pro  Val Ser Glu Ser Val  Leu Cys Thr 
    1160                 1165                 1170             


Pro Pro  Asn Val Ser Tyr Ala  Ser Val Ile Leu Arg  Asp Tyr Lys 
    1175                 1180                 1185             


Gln Ser  Ser Ser Thr Leu 
    1190                 


<210>  289
<211>  872
<212>  PRT
<213>  Homo sapiens

<400>  289

Met Gly Ser Leu Leu Ala Leu Leu Ala Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Glu Gly Pro Ala Lys Lys Val Leu Thr Leu Glu Gly Asp Leu 
            20                  25                  30          


Val Leu Gly Gly Leu Phe Pro Val His Gln Lys Gly Gly Pro Ala Glu 
        35                  40                  45              


Asp Cys Gly Pro Val Asn Glu His Arg Gly Ile Gln Arg Leu Glu Ala 
    50                  55                  60                  


Met Leu Phe Ala Leu Asp Arg Ile Asn Arg Asp Pro His Leu Leu Pro 
65                  70                  75                  80  


Gly Val Arg Leu Gly Ala His Ile Leu Asp Ser Cys Ser Lys Asp Thr 
                85                  90                  95      


His Ala Leu Glu Gln Ala Leu Asp Phe Val Arg Ala Ser Leu Ser Arg 
            100                 105                 110         


Gly Ala Asp Gly Ser Arg His Ile Cys Pro Asp Gly Ser Tyr Ala Thr 
        115                 120                 125             


His Gly Asp Ala Pro Thr Ala Ile Thr Gly Val Ile Gly Gly Ser Tyr 
    130                 135                 140                 


Ser Asp Val Ser Ile Gln Val Ala Asn Leu Leu Arg Leu Phe Gln Ile 
145                 150                 155                 160 


Pro Gln Ile Ser Tyr Ala Ser Thr Ser Ala Lys Leu Ser Asp Lys Ser 
                165                 170                 175     


Arg Tyr Asp Tyr Phe Ala Arg Thr Val Pro Pro Asp Phe Phe Gln Ala 
            180                 185                 190         


Lys Ala Met Ala Glu Ile Leu Arg Phe Phe Asn Trp Thr Tyr Val Ser 
        195                 200                 205             


Thr Val Ala Ser Glu Gly Asp Tyr Gly Glu Thr Gly Ile Glu Ala Phe 
    210                 215                 220                 


Glu Leu Glu Ala Arg Ala Arg Asn Ile Cys Val Ala Thr Ser Glu Lys 
225                 230                 235                 240 


Val Gly Arg Ala Met Ser Arg Ala Ala Phe Glu Gly Val Val Arg Ala 
                245                 250                 255     


Leu Leu Gln Lys Pro Ser Ala Arg Val Ala Val Leu Phe Thr Arg Ser 
            260                 265                 270         


Glu Asp Ala Arg Glu Leu Leu Ala Ala Ser Gln Arg Leu Asn Ala Ser 
        275                 280                 285             


Phe Thr Trp Val Ala Ser Asp Gly Trp Gly Ala Leu Glu Ser Val Val 
    290                 295                 300                 


Ala Gly Ser Glu Gly Ala Ala Glu Gly Ala Ile Thr Ile Glu Leu Ala 
305                 310                 315                 320 


Ser Tyr Pro Ile Ser Asp Phe Ala Ser Tyr Phe Gln Ser Leu Asp Pro 
                325                 330                 335     


Trp Asn Asn Ser Arg Asn Pro Trp Phe Arg Glu Phe Trp Glu Gln Arg 
            340                 345                 350         


Phe Arg Cys Ser Phe Arg Gln Arg Asp Cys Ala Ala His Ser Leu Arg 
        355                 360                 365             


Ala Val Pro Phe Glu Gln Glu Ser Lys Ile Met Phe Val Val Asn Ala 
    370                 375                 380                 


Val Tyr Ala Met Ala His Ala Leu His Asn Met His Arg Ala Leu Cys 
385                 390                 395                 400 


Pro Asn Thr Thr Arg Leu Cys Asp Ala Met Arg Pro Val Asn Gly Arg 
                405                 410                 415     


Arg Leu Tyr Lys Asp Phe Val Leu Asn Val Lys Phe Asp Ala Pro Phe 
            420                 425                 430         


Arg Pro Ala Asp Thr His Asn Glu Val Arg Phe Asp Arg Phe Gly Asp 
        435                 440                 445             


Gly Ile Gly Arg Tyr Asn Ile Phe Thr Tyr Leu Arg Ala Gly Ser Gly 
    450                 455                 460                 


Arg Tyr Arg Tyr Gln Lys Val Gly Tyr Trp Ala Glu Gly Leu Thr Leu 
465                 470                 475                 480 


Asp Thr Ser Leu Ile Pro Trp Ala Ser Pro Ser Ala Gly Pro Leu Pro 
                485                 490                 495     


Ala Ser Arg Cys Ser Glu Pro Cys Leu Gln Asn Glu Val Lys Ser Val 
            500                 505                 510         


Gln Pro Gly Glu Val Cys Cys Trp Leu Cys Ile Pro Cys Gln Pro Tyr 
        515                 520                 525             


Glu Tyr Arg Leu Asp Glu Phe Thr Cys Ala Asp Cys Gly Leu Gly Tyr 
    530                 535                 540                 


Trp Pro Asn Ala Ser Leu Thr Gly Cys Phe Glu Leu Pro Gln Glu Tyr 
545                 550                 555                 560 


Ile Arg Trp Gly Asp Ala Trp Ala Val Gly Pro Val Thr Ile Ala Cys 
                565                 570                 575     


Leu Gly Ala Leu Ala Thr Leu Phe Val Leu Gly Val Phe Val Arg His 
            580                 585                 590         


Asn Ala Thr Pro Val Val Lys Ala Ser Gly Arg Glu Leu Cys Tyr Ile 
        595                 600                 605             


Leu Leu Gly Gly Val Phe Leu Cys Tyr Cys Met Thr Phe Ile Phe Ile 
    610                 615                 620                 


Ala Lys Pro Ser Thr Ala Val Cys Thr Leu Arg Arg Leu Gly Leu Gly 
625                 630                 635                 640 


Thr Ala Phe Ser Val Cys Tyr Ser Ala Leu Leu Thr Lys Thr Asn Arg 
                645                 650                 655     


Ile Ala Arg Ile Phe Gly Gly Ala Arg Glu Gly Ala Gln Arg Pro Arg 
            660                 665                 670         


Phe Ile Ser Pro Ala Ser Gln Val Ala Ile Cys Leu Ala Leu Ile Ser 
        675                 680                 685             


Gly Gln Leu Leu Ile Val Val Ala Trp Leu Val Val Glu Ala Pro Gly 
    690                 695                 700                 


Thr Gly Lys Glu Thr Ala Pro Glu Arg Arg Glu Val Val Thr Leu Arg 
705                 710                 715                 720 


Cys Asn His Arg Asp Ala Ser Met Leu Gly Ser Leu Ala Tyr Asn Val 
                725                 730                 735     


Leu Leu Ile Ala Leu Cys Thr Leu Tyr Ala Phe Lys Thr Arg Lys Cys 
            740                 745                 750         


Pro Glu Asn Phe Asn Glu Ala Lys Phe Ile Gly Phe Thr Met Tyr Thr 
        755                 760                 765             


Thr Cys Ile Ile Trp Leu Ala Phe Leu Pro Ile Phe Tyr Val Thr Ser 
    770                 775                 780                 


Ser Asp Tyr Arg Val Gln Thr Thr Thr Met Cys Val Ser Val Ser Leu 
785                 790                 795                 800 


Ser Gly Ser Val Val Leu Gly Cys Leu Phe Ala Pro Lys Leu His Ile 
                805                 810                 815     


Ile Leu Phe Gln Pro Gln Lys Asn Val Val Ser His Arg Ala Pro Thr 
            820                 825                 830         


Ser Arg Phe Gly Ser Ala Ala Ala Arg Ala Ser Ser Ser Leu Gly Gln 
        835                 840                 845             


Gly Ser Gly Ser Gln Phe Val Pro Thr Val Cys Asn Gly Arg Glu Val 
    850                 855                 860                 


Val Asp Ser Thr Thr Ser Ser Leu 
865                 870         


<210>  290
<211>  879
<212>  PRT
<213>  Homo sapiens

<400>  290

Met Lys Met Leu Thr Arg Leu Gln Val Leu Thr Leu Ala Leu Phe Ser 
1               5                   10                  15      


Lys Gly Phe Leu Leu Ser Leu Gly Asp His Asn Phe Leu Arg Arg Glu 
            20                  25                  30          


Ile Lys Ile Glu Gly Asp Leu Val Leu Gly Gly Leu Phe Pro Ile Asn 
        35                  40                  45              


Glu Lys Gly Thr Gly Thr Glu Glu Cys Gly Arg Ile Asn Glu Asp Arg 
    50                  55                  60                  


Gly Ile Gln Arg Leu Glu Ala Met Leu Phe Ala Ile Asp Glu Ile Asn 
65                  70                  75                  80  


Lys Asp Asp Tyr Leu Leu Pro Gly Val Lys Leu Gly Val His Ile Leu 
                85                  90                  95      


Asp Thr Cys Ser Arg Asp Thr Tyr Ala Leu Glu Gln Ser Leu Glu Phe 
            100                 105                 110         


Val Arg Ala Ser Leu Thr Lys Val Asp Glu Ala Glu Tyr Met Cys Pro 
        115                 120                 125             


Asp Gly Ser Tyr Ala Ile Gln Glu Asn Ile Pro Leu Leu Ile Ala Gly 
    130                 135                 140                 


Val Ile Gly Gly Ser Tyr Ser Ser Val Ser Ile Gln Val Ala Asn Leu 
145                 150                 155                 160 


Leu Arg Leu Phe Gln Ile Pro Gln Ile Ser Tyr Ala Ser Thr Ser Ala 
                165                 170                 175     


Lys Leu Ser Asp Lys Ser Arg Tyr Asp Tyr Phe Ala Arg Thr Val Pro 
            180                 185                 190         


Pro Asp Phe Tyr Gln Ala Lys Ala Met Ala Glu Ile Leu Arg Phe Phe 
        195                 200                 205             


Asn Trp Thr Tyr Val Ser Thr Val Ala Ser Glu Gly Asp Tyr Gly Glu 
    210                 215                 220                 


Thr Gly Ile Glu Ala Phe Glu Gln Glu Ala Arg Leu Arg Asn Ile Cys 
225                 230                 235                 240 


Ile Ala Thr Ala Glu Lys Val Gly Arg Ser Asn Ile Arg Lys Ser Tyr 
                245                 250                 255     


Asp Ser Val Ile Arg Glu Leu Leu Gln Lys Pro Asn Ala Arg Val Val 
            260                 265                 270         


Val Leu Phe Met Arg Ser Asp Asp Ser Arg Glu Leu Ile Ala Ala Ala 
        275                 280                 285             


Ser Arg Ala Asn Ala Ser Phe Thr Trp Val Ala Ser Asp Gly Trp Gly 
    290                 295                 300                 


Ala Gln Glu Ser Ile Ile Lys Gly Ser Glu His Val Ala Tyr Gly Ala 
305                 310                 315                 320 


Ile Thr Leu Glu Leu Ala Ser Gln Pro Val Arg Gln Phe Asp Arg Tyr 
                325                 330                 335     


Phe Gln Ser Leu Asn Pro Tyr Asn Asn His Arg Asn Pro Trp Phe Arg 
            340                 345                 350         


Asp Phe Trp Glu Gln Lys Phe Gln Cys Ser Leu Gln Asn Lys Arg Asn 
        355                 360                 365             


His Arg Arg Val Cys Asp Lys His Leu Ala Ile Asp Ser Ser Asn Tyr 
    370                 375                 380                 


Glu Gln Glu Ser Lys Ile Met Phe Val Val Asn Ala Val Tyr Ala Met 
385                 390                 395                 400 


Ala His Ala Leu His Lys Met Gln Arg Thr Leu Cys Pro Asn Thr Thr 
                405                 410                 415     


Lys Leu Cys Asp Ala Met Lys Ile Leu Asp Gly Lys Lys Leu Tyr Lys 
            420                 425                 430         


Asp Tyr Leu Leu Lys Ile Asn Phe Thr Ala Pro Phe Asn Pro Asn Lys 
        435                 440                 445             


Asp Ala Asp Ser Ile Val Lys Phe Asp Thr Phe Gly Asp Gly Met Gly 
    450                 455                 460                 


Arg Tyr Asn Val Phe Asn Phe Gln Asn Val Gly Gly Lys Tyr Ser Tyr 
465                 470                 475                 480 


Leu Lys Val Gly His Trp Ala Glu Thr Leu Ser Leu Asp Val Asn Ser 
                485                 490                 495     


Ile His Trp Ser Arg Asn Ser Val Pro Thr Ser Gln Cys Ser Asp Pro 
            500                 505                 510         


Cys Ala Pro Asn Glu Met Lys Asn Met Gln Pro Gly Asp Val Cys Cys 
        515                 520                 525             


Trp Ile Cys Ile Pro Cys Glu Pro Tyr Glu Tyr Leu Ala Asp Glu Phe 
    530                 535                 540                 


Thr Cys Met Asp Cys Gly Ser Gly Gln Trp Pro Thr Ala Asp Leu Thr 
545                 550                 555                 560 


Gly Cys Tyr Asp Leu Pro Glu Asp Tyr Ile Arg Trp Glu Asp Ala Trp 
                565                 570                 575     


Ala Ile Gly Pro Val Thr Ile Ala Cys Leu Gly Phe Met Cys Thr Cys 
            580                 585                 590         


Met Val Val Thr Val Phe Ile Lys His Asn Asn Thr Pro Leu Val Lys 
        595                 600                 605             


Ala Ser Gly Arg Glu Leu Cys Tyr Ile Leu Leu Phe Gly Val Gly Leu 
    610                 615                 620                 


Ser Tyr Cys Met Thr Phe Phe Phe Ile Ala Lys Pro Ser Pro Val Ile 
625                 630                 635                 640 


Cys Ala Leu Arg Arg Leu Gly Leu Gly Ser Ser Phe Ala Ile Cys Tyr 
                645                 650                 655     


Ser Ala Leu Leu Thr Lys Thr Asn Cys Ile Ala Arg Ile Phe Asp Gly 
            660                 665                 670         


Val Lys Asn Gly Ala Gln Arg Pro Lys Phe Ile Ser Pro Ser Ser Gln 
        675                 680                 685             


Val Phe Ile Cys Leu Gly Leu Ile Leu Val Gln Ile Val Met Val Ser 
    690                 695                 700                 


Val Trp Leu Ile Leu Glu Ala Pro Gly Thr Arg Arg Tyr Thr Leu Ala 
705                 710                 715                 720 


Glu Lys Arg Glu Thr Val Ile Leu Lys Cys Asn Val Lys Asp Ser Ser 
                725                 730                 735     


Met Leu Ile Ser Leu Thr Tyr Asp Val Ile Leu Val Ile Leu Cys Thr 
            740                 745                 750         


Val Tyr Ala Phe Lys Thr Arg Lys Cys Pro Glu Asn Phe Asn Glu Ala 
        755                 760                 765             


Lys Phe Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala 
    770                 775                 780                 


Phe Leu Pro Ile Phe Tyr Val Thr Ser Ser Asp Tyr Arg Val Gln Thr 
785                 790                 795                 800 


Thr Thr Met Cys Ile Ser Val Ser Leu Ser Gly Phe Val Val Leu Gly 
                805                 810                 815     


Cys Leu Phe Ala Pro Lys Val His Ile Ile Leu Phe Gln Pro Gln Lys 
            820                 825                 830         


Asn Val Val Thr His Arg Leu His Leu Asn Arg Phe Ser Val Ser Gly 
        835                 840                 845             


Thr Gly Thr Thr Tyr Ser Gln Ser Ser Ala Ser Thr Tyr Val Pro Thr 
    850                 855                 860                 


Val Cys Asn Gly Arg Glu Val Leu Asp Ser Thr Thr Ser Ser Leu 
865                 870                 875                 


<210>  291
<211>  912
<212>  PRT
<213>  Homo sapiens

<400>  291

Met Pro Gly Lys Arg Gly Leu Gly Trp Trp Trp Ala Arg Leu Pro Leu 
1               5                   10                  15      


Cys Leu Leu Leu Ser Leu Tyr Gly Pro Trp Met Pro Ser Ser Leu Gly 
            20                  25                  30          


Lys Pro Lys Gly His Pro His Met Asn Ser Ile Arg Ile Asp Gly Asp 
        35                  40                  45              


Ile Thr Leu Gly Gly Leu Phe Pro Val His Gly Arg Gly Ser Glu Gly 
    50                  55                  60                  


Lys Pro Cys Gly Glu Leu Lys Lys Glu Lys Gly Ile His Arg Leu Glu 
65                  70                  75                  80  


Ala Met Leu Phe Ala Leu Asp Arg Ile Asn Asn Asp Pro Asp Leu Leu 
                85                  90                  95      


Pro Asn Ile Thr Leu Gly Ala Arg Ile Leu Asp Thr Cys Ser Arg Asp 
            100                 105                 110         


Thr His Ala Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Glu 
        115                 120                 125             


Lys Asp Gly Thr Glu Val Arg Cys Gly Ser Gly Gly Pro Pro Ile Ile 
    130                 135                 140                 


Thr Lys Pro Glu Arg Val Val Gly Val Ile Gly Ala Ser Gly Ser Ser 
145                 150                 155                 160 


Val Ser Ile Met Val Ala Asn Ile Leu Arg Leu Phe Lys Ile Pro Gln 
                165                 170                 175     


Ile Ser Tyr Ala Ser Thr Ala Pro Asp Leu Ser Asp Asn Ser Arg Tyr 
            180                 185                 190         


Asp Phe Phe Ser Arg Val Val Pro Ser Asp Thr Tyr Gln Ala Gln Ala 
        195                 200                 205             


Met Val Asp Ile Val Arg Ala Leu Lys Trp Asn Tyr Val Ser Thr Val 
    210                 215                 220                 


Ala Ser Glu Gly Ser Tyr Gly Glu Ser Gly Val Glu Ala Phe Ile Gln 
225                 230                 235                 240 


Lys Ser Arg Glu Asp Gly Gly Val Cys Ile Ala Gln Ser Val Lys Ile 
                245                 250                 255     


Pro Arg Glu Pro Lys Ala Gly Glu Phe Asp Lys Ile Ile Arg Arg Leu 
            260                 265                 270         


Leu Glu Thr Ser Asn Ala Arg Ala Val Ile Ile Phe Ala Asn Glu Asp 
        275                 280                 285             


Asp Ile Arg Arg Val Leu Glu Ala Ala Arg Arg Ala Asn Gln Thr Gly 
    290                 295                 300                 


His Phe Phe Trp Met Gly Ser Asp Ser Trp Gly Ser Lys Ile Ala Pro 
305                 310                 315                 320 


Val Leu His Leu Glu Glu Val Ala Glu Gly Ala Val Thr Ile Leu Pro 
                325                 330                 335     


Lys Arg Met Ser Val Arg Gly Phe Asp Arg Tyr Phe Ser Ser Arg Thr 
            340                 345                 350         


Leu Asp Asn Asn Arg Arg Asn Ile Trp Phe Ala Glu Phe Trp Glu Asp 
        355                 360                 365             


Asn Phe His Cys Lys Leu Ser Arg His Ala Leu Lys Lys Gly Ser His 
    370                 375                 380                 


Val Lys Lys Cys Thr Asn Arg Glu Arg Ile Gly Gln Asp Ser Ala Tyr 
385                 390                 395                 400 


Glu Gln Glu Gly Lys Val Gln Phe Val Ile Asp Ala Val Tyr Ala Met 
                405                 410                 415     


Gly His Ala Leu His Ala Met His Arg Asp Leu Cys Pro Gly Arg Val 
            420                 425                 430         


Gly Leu Cys Pro Arg Met Asp Pro Val Asp Gly Thr Gln Leu Leu Lys 
        435                 440                 445             


Tyr Ile Arg Asn Val Asn Phe Ser Gly Ile Ala Gly Asn Pro Val Thr 
    450                 455                 460                 


Phe Asn Glu Asn Gly Asp Ala Pro Gly Arg Tyr Asp Ile Tyr Gln Tyr 
465                 470                 475                 480 


Gln Leu Arg Asn Asp Ser Ala Glu Tyr Lys Val Ile Gly Ser Trp Thr 
                485                 490                 495     


Asp His Leu His Leu Arg Ile Glu Arg Met His Trp Pro Gly Ser Gly 
            500                 505                 510         


Gln Gln Leu Pro Arg Ser Ile Cys Ser Leu Pro Cys Gln Pro Gly Glu 
        515                 520                 525             


Arg Lys Lys Thr Val Lys Gly Met Pro Cys Cys Trp His Cys Glu Pro 
    530                 535                 540                 


Cys Thr Gly Tyr Gln Tyr Gln Val Asp Arg Tyr Thr Cys Lys Thr Cys 
545                 550                 555                 560 


Pro Tyr Asp Met Arg Pro Thr Glu Asn Arg Thr Gly Cys Arg Pro Ile 
                565                 570                 575     


Pro Ile Ile Lys Leu Glu Trp Gly Ser Pro Trp Ala Val Leu Pro Leu 
            580                 585                 590         


Phe Leu Ala Val Val Gly Ile Ala Ala Thr Leu Phe Val Val Ile Thr 
        595                 600                 605             


Phe Val Arg Tyr Asn Asp Thr Pro Ile Val Lys Ala Ser Gly Arg Glu 
    610                 615                 620                 


Leu Ser Tyr Val Leu Leu Ala Gly Ile Phe Leu Cys Tyr Ala Thr Thr 
625                 630                 635                 640 


Phe Leu Met Ile Ala Glu Pro Asp Leu Gly Thr Cys Ser Leu Arg Arg 
                645                 650                 655     


Ile Phe Leu Gly Leu Gly Met Ser Ile Ser Tyr Ala Ala Leu Leu Thr 
            660                 665                 670         


Lys Thr Asn Arg Ile Tyr Arg Ile Phe Glu Gln Gly Lys Arg Ser Val 
        675                 680                 685             


Ser Ala Pro Arg Phe Ile Ser Pro Ala Ser Gln Leu Ala Ile Thr Phe 
    690                 695                 700                 


Ser Leu Ile Ser Leu Gln Leu Leu Gly Ile Cys Val Trp Phe Val Val 
705                 710                 715                 720 


Asp Pro Ser His Ser Val Val Asp Phe Gln Asp Gln Arg Thr Leu Asp 
                725                 730                 735     


Pro Arg Phe Ala Arg Gly Val Leu Lys Cys Asp Ile Ser Asp Leu Ser 
            740                 745                 750         


Leu Ile Cys Leu Leu Gly Tyr Ser Met Leu Leu Met Val Thr Cys Thr 
        755                 760                 765             


Val Tyr Ala Ile Lys Thr Arg Gly Val Pro Glu Thr Phe Asn Glu Ala 
    770                 775                 780                 


Lys Pro Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Val Trp Leu Ala 
785                 790                 795                 800 


Phe Ile Pro Ile Phe Phe Gly Thr Ser Gln Ser Ala Asp Lys Leu Tyr 
                805                 810                 815     


Ile Gln Thr Thr Thr Leu Thr Val Ser Val Ser Leu Ser Ala Ser Val 
            820                 825                 830         


Ser Leu Gly Met Leu Tyr Met Pro Lys Val Tyr Ile Ile Leu Phe His 
        835                 840                 845             


Pro Glu Gln Asn Val Pro Lys Arg Lys Arg Ser Leu Lys Ala Val Val 
    850                 855                 860                 


Thr Ala Ala Thr Met Ser Asn Lys Phe Thr Gln Lys Gly Asn Phe Arg 
865                 870                 875                 880 


Pro Asn Gly Glu Ala Lys Ser Glu Leu Cys Glu Asn Leu Glu Ala Pro 
                885                 890                 895     


Ala Leu Ala Thr Lys Gln Thr Tyr Val Thr Tyr Thr Asn His Ala Ile 
            900                 905                 910         


<210>  292
<211>  1180
<212>  PRT
<213>  Homo sapiens

<400>  292

Met Val Leu Leu Leu Ile Leu Ser Val Leu Leu Leu Lys Glu Asp Val 
1               5                   10                  15      


Arg Gly Ser Ala Gln Ser Ser Glu Arg Arg Val Val Ala His Met Pro 
            20                  25                  30          


Gly Asp Ile Ile Ile Gly Ala Leu Phe Ser Val His His Gln Pro Thr 
        35                  40                  45              


Val Asp Lys Val His Glu Arg Lys Cys Gly Ala Val Arg Glu Gln Tyr 
    50                  55                  60                  


Gly Ile Gln Arg Val Glu Ala Met Leu His Thr Leu Glu Arg Ile Asn 
65                  70                  75                  80  


Ser Asp Pro Thr Leu Leu Pro Asn Ile Thr Leu Gly Cys Glu Ile Arg 
                85                  90                  95      


Asp Ser Cys Trp His Ser Ala Val Ala Leu Glu Gln Ser Ile Glu Phe 
            100                 105                 110         


Ile Arg Asp Ser Leu Ile Ser Ser Glu Glu Glu Glu Gly Leu Val Arg 
        115                 120                 125             


Cys Val Asp Gly Ser Ser Ser Ser Phe Arg Ser Lys Lys Pro Ile Val 
    130                 135                 140                 


Gly Val Ile Gly Pro Gly Ser Ser Ser Val Ala Ile Gln Val Gln Asn 
145                 150                 155                 160 


Leu Leu Gln Leu Phe Asn Ile Pro Gln Ile Ala Tyr Ser Ala Thr Ser 
                165                 170                 175     


Met Asp Leu Ser Asp Lys Thr Leu Phe Lys Tyr Phe Met Arg Val Val 
            180                 185                 190         


Pro Ser Asp Ala Gln Gln Ala Arg Ala Met Val Asp Ile Val Lys Arg 
        195                 200                 205             


Tyr Asn Trp Thr Tyr Val Ser Ala Val His Thr Glu Gly Asn Tyr Gly 
    210                 215                 220                 


Glu Ser Gly Met Glu Ala Phe Lys Asp Met Ser Ala Lys Glu Gly Ile 
225                 230                 235                 240 


Cys Ile Ala His Ser Tyr Lys Ile Tyr Ser Asn Ala Gly Glu Gln Ser 
                245                 250                 255     


Phe Asp Lys Leu Leu Lys Lys Leu Thr Ser His Leu Pro Lys Ala Arg 
            260                 265                 270         


Val Val Ala Cys Phe Cys Glu Gly Met Thr Val Arg Gly Leu Leu Met 
        275                 280                 285             


Ala Met Arg Arg Leu Gly Leu Ala Gly Glu Phe Leu Leu Leu Gly Ser 
    290                 295                 300                 


Asp Gly Trp Ala Asp Arg Tyr Asp Val Thr Asp Gly Tyr Gln Arg Glu 
305                 310                 315                 320 


Ala Val Gly Gly Ile Thr Ile Lys Leu Gln Ser Pro Asp Val Lys Trp 
                325                 330                 335     


Phe Asp Asp Tyr Tyr Leu Lys Leu Arg Pro Glu Thr Asn His Arg Asn 
            340                 345                 350         


Pro Trp Phe Gln Glu Phe Trp Gln His Arg Phe Gln Cys Arg Leu Glu 
        355                 360                 365             


Gly Phe Pro Gln Glu Asn Ser Lys Tyr Asn Lys Thr Cys Asn Ser Ser 
    370                 375                 380                 


Leu Thr Leu Lys Thr His His Val Gln Asp Ser Lys Met Gly Phe Val 
385                 390                 395                 400 


Ile Asn Ala Ile Tyr Ser Met Ala Tyr Gly Leu His Asn Met Gln Met 
                405                 410                 415     


Ser Leu Cys Pro Gly Tyr Ala Gly Leu Cys Asp Ala Met Lys Pro Ile 
            420                 425                 430         


Asp Gly Arg Lys Leu Leu Glu Ser Leu Met Lys Thr Asn Phe Thr Gly 
        435                 440                 445             


Val Ser Gly Asp Thr Ile Leu Phe Asp Glu Asn Gly Asp Ser Pro Gly 
    450                 455                 460                 


Arg Tyr Glu Ile Met Asn Phe Lys Glu Met Gly Lys Asp Tyr Phe Asp 
465                 470                 475                 480 


Tyr Ile Asn Val Gly Ser Trp Asp Asn Gly Glu Leu Lys Met Asp Asp 
                485                 490                 495     


Asp Glu Val Trp Ser Lys Lys Ser Asn Ile Ile Arg Ser Val Cys Ser 
            500                 505                 510         


Glu Pro Cys Glu Lys Gly Gln Ile Lys Val Ile Arg Lys Gly Glu Val 
        515                 520                 525             


Ser Cys Cys Trp Thr Cys Thr Pro Cys Lys Glu Asn Glu Tyr Val Phe 
    530                 535                 540                 


Asp Glu Tyr Thr Cys Lys Ala Cys Gln Leu Gly Ser Trp Pro Thr Asp 
545                 550                 555                 560 


Asp Leu Thr Gly Cys Asp Leu Ile Pro Val Gln Tyr Leu Arg Trp Gly 
                565                 570                 575     


Asp Pro Glu Pro Ile Ala Ala Val Val Phe Ala Cys Leu Gly Leu Leu 
            580                 585                 590         


Ala Thr Leu Phe Val Thr Val Val Phe Ile Ile Tyr Arg Asp Thr Pro 
        595                 600                 605             


Val Val Lys Ser Ser Ser Arg Glu Leu Cys Tyr Ile Ile Leu Ala Gly 
    610                 615                 620                 


Ile Cys Leu Gly Tyr Leu Cys Thr Phe Cys Leu Ile Ala Lys Pro Lys 
625                 630                 635                 640 


Gln Ile Tyr Cys Tyr Leu Gln Arg Ile Gly Ile Gly Leu Ser Pro Ala 
                645                 650                 655     


Met Ser Tyr Ser Ala Leu Val Thr Lys Thr Asn Arg Ile Ala Arg Ile 
            660                 665                 670         


Leu Ala Gly Ser Lys Lys Lys Ile Cys Thr Lys Lys Pro Arg Phe Met 
        675                 680                 685             


Ser Ala Cys Ala Gln Leu Val Ile Ala Phe Ile Leu Ile Cys Ile Gln 
    690                 695                 700                 


Leu Gly Ile Ile Val Ala Leu Phe Ile Met Glu Pro Pro Asp Ile Met 
705                 710                 715                 720 


His Asp Tyr Pro Ser Ile Arg Glu Val Tyr Leu Ile Cys Asn Thr Thr 
                725                 730                 735     


Asn Leu Gly Val Val Thr Pro Leu Gly Tyr Asn Gly Leu Leu Ile Leu 
            740                 745                 750         


Ser Cys Thr Phe Tyr Ala Phe Lys Thr Arg Asn Val Pro Ala Asn Phe 
        755                 760                 765             


Asn Glu Ala Lys Tyr Ile Ala Phe Thr Met Tyr Thr Thr Cys Ile Ile 
    770                 775                 780                 


Trp Leu Ala Phe Val Pro Ile Tyr Phe Gly Ser Asn Tyr Lys Ile Ile 
785                 790                 795                 800 


Thr Met Cys Phe Ser Val Ser Leu Ser Ala Thr Val Ala Leu Gly Cys 
                805                 810                 815     


Met Phe Val Pro Lys Val Tyr Ile Ile Leu Ala Lys Pro Glu Arg Asn 
            820                 825                 830         


Val Arg Ser Ala Phe Thr Thr Ser Thr Val Val Arg Met His Val Gly 
        835                 840                 845             


Asp Gly Lys Ser Ser Ser Ala Ala Ser Arg Ser Ser Ser Leu Val Asn 
    850                 855                 860                 


Leu Trp Lys Arg Arg Gly Ser Ser Gly Glu Thr Leu Ser Ser Asn Gly 
865                 870                 875                 880 


Lys Ser Val Thr Trp Ala Gln Asn Glu Lys Ser Ser Arg Gly Gln His 
                885                 890                 895     


Leu Trp Gln Arg Leu Ser Ile His Ile Asn Lys Lys Glu Asn Pro Asn 
            900                 905                 910         


Gln Thr Ala Val Ile Lys Pro Phe Pro Lys Ser Thr Glu Ser Arg Gly 
        915                 920                 925             


Leu Gly Ala Gly Ala Gly Ala Gly Gly Ser Ala Gly Gly Val Gly Ala 
    930                 935                 940                 


Thr Gly Gly Ala Gly Cys Ala Gly Ala Gly Pro Gly Gly Pro Glu Ser 
945                 950                 955                 960 


Pro Asp Ala Gly Pro Lys Ala Leu Tyr Asp Val Ala Glu Ala Glu Glu 
                965                 970                 975     


His Phe Pro Ala Pro Ala Arg Pro Arg Ser Pro Ser Pro Ile Ser Thr 
            980                 985                 990         


Leu Ser His Arg Ala Gly Ser Ala  Ser Arg Thr Asp Asp  Asp Val Pro 
        995                 1000                 1005             


Ser Leu  His Ser Glu Pro Val  Ala Arg Ser Ser Ser  Ser Gln Gly 
    1010                 1015                 1020             


Ser Leu  Met Glu Gln Ile Ser  Ser Val Val Thr Arg  Phe Thr Ala 
    1025                 1030                 1035             


Asn Ile  Ser Glu Leu Asn Ser  Met Met Leu Ser Thr  Ala Ala Pro 
    1040                 1045                 1050             


Ser Pro  Gly Val Gly Ala Pro  Leu Cys Ser Ser Tyr  Leu Ile Pro 
    1055                 1060                 1065             


Lys Glu  Ile Gln Leu Pro Thr  Thr Met Thr Thr Phe  Ala Glu Ile 
    1070                 1075                 1080             


Gln Pro  Leu Pro Ala Ile Glu  Val Thr Gly Gly Ala  Gln Pro Ala 
    1085                 1090                 1095             


Ala Gly  Ala Gln Ala Ala Gly  Asp Ala Ala Arg Glu  Ser Pro Ala 
    1100                 1105                 1110             


Ala Gly  Pro Glu Ala Ala Ala  Ala Lys Pro Asp Leu  Glu Glu Leu 
    1115                 1120                 1125             


Val Ala  Leu Thr Pro Pro Ser  Pro Phe Arg Asp Ser  Val Asp Ser 
    1130                 1135                 1140             


Gly Ser  Thr Thr Pro Asn Ser  Pro Val Ser Glu Ser  Ala Leu Cys 
    1145                 1150                 1155             


Ile Pro  Ser Ser Pro Lys Tyr  Asp Thr Leu Ile Ile  Arg Asp Tyr 
    1160                 1165                 1170             


Thr Gln  Ser Ser Ser Ser Leu  
    1175                 1180 


<210>  293
<211>  877
<212>  PRT
<213>  Homo sapiens

<400>  293

Met Ala Arg Pro Arg Arg Ala Arg Glu Pro Leu Leu Val Ala Leu Leu 
1               5                   10                  15      


Pro Leu Ala Trp Leu Ala Gln Ala Gly Leu Ala Arg Ala Ala Gly Ser 
            20                  25                  30          


Val Arg Leu Ala Gly Gly Leu Thr Leu Gly Gly Leu Phe Pro Val His 
        35                  40                  45              


Ala Arg Gly Ala Ala Gly Arg Ala Cys Gly Gln Leu Lys Lys Glu Gln 
    50                  55                  60                  


Gly Val His Arg Leu Glu Ala Met Leu Tyr Ala Leu Asp Arg Val Asn 
65                  70                  75                  80  


Ala Asp Pro Glu Leu Leu Pro Gly Val Arg Leu Gly Ala Arg Leu Leu 
                85                  90                  95      


Asp Thr Cys Ser Arg Asp Thr Tyr Ala Leu Glu Gln Ala Leu Ser Phe 
            100                 105                 110         


Val Gln Ala Leu Ile Arg Gly Arg Gly Asp Gly Asp Glu Val Gly Val 
        115                 120                 125             


Arg Cys Pro Gly Gly Val Pro Pro Leu Arg Pro Ala Pro Pro Glu Arg 
    130                 135                 140                 


Val Val Ala Val Val Gly Ala Ser Ala Ser Ser Val Ser Ile Met Val 
145                 150                 155                 160 


Ala Asn Val Leu Arg Leu Phe Ala Ile Pro Gln Ile Ser Tyr Ala Ser 
                165                 170                 175     


Thr Ala Pro Glu Leu Ser Asp Ser Thr Arg Tyr Asp Phe Phe Ser Arg 
            180                 185                 190         


Val Val Pro Pro Asp Ser Tyr Gln Ala Gln Ala Met Val Asp Ile Val 
        195                 200                 205             


Arg Ala Leu Gly Trp Asn Tyr Val Ser Thr Leu Ala Ser Glu Gly Asn 
    210                 215                 220                 


Tyr Gly Glu Ser Gly Val Glu Ala Phe Val Gln Ile Ser Arg Glu Ala 
225                 230                 235                 240 


Gly Gly Val Cys Ile Ala Gln Ser Ile Lys Ile Pro Arg Glu Pro Lys 
                245                 250                 255     


Pro Gly Glu Phe Ser Lys Val Ile Arg Arg Leu Met Glu Thr Pro Asn 
            260                 265                 270         


Ala Arg Gly Ile Ile Ile Phe Ala Asn Glu Asp Asp Ile Arg Arg Val 
        275                 280                 285             


Leu Glu Ala Ala Arg Gln Ala Asn Leu Thr Gly His Phe Leu Trp Val 
    290                 295                 300                 


Gly Ser Asp Ser Trp Gly Ala Lys Thr Ser Pro Ile Leu Ser Leu Glu 
305                 310                 315                 320 


Asp Val Ala Val Gly Ala Ile Thr Ile Leu Pro Lys Arg Ala Ser Ile 
                325                 330                 335     


Asp Gly Phe Asp Gln Tyr Phe Met Thr Arg Ser Leu Glu Asn Asn Arg 
            340                 345                 350         


Arg Asn Ile Trp Phe Ala Glu Phe Trp Glu Glu Asn Phe Asn Cys Lys 
        355                 360                 365             


Leu Thr Ser Ser Gly Thr Gln Ser Asp Asp Ser Thr Arg Lys Cys Thr 
    370                 375                 380                 


Gly Glu Glu Arg Ile Gly Arg Asp Ser Thr Tyr Glu Gln Glu Gly Lys 
385                 390                 395                 400 


Val Gln Phe Val Ile Asp Ala Val Tyr Ala Ile Ala His Ala Leu His 
                405                 410                 415     


Ser Met His Gln Ala Leu Cys Pro Gly His Thr Gly Leu Cys Pro Ala 
            420                 425                 430         


Met Glu Pro Thr Asp Gly Arg Met Leu Leu Gln Tyr Ile Arg Ala Val 
        435                 440                 445             


Arg Phe Asn Gly Ser Ala Gly Thr Pro Val Met Phe Asn Glu Asn Gly 
    450                 455                 460                 


Asp Ala Pro Gly Arg Tyr Asp Ile Phe Gln Tyr Gln Ala Thr Asn Gly 
465                 470                 475                 480 


Ser Ala Ser Ser Gly Gly Tyr Gln Ala Val Gly Gln Trp Ala Glu Thr 
                485                 490                 495     


Leu Arg Leu Asp Val Glu Ala Leu Gln Trp Ser Gly Asp Pro His Glu 
            500                 505                 510         


Val Pro Ser Ser Leu Cys Ser Leu Pro Cys Gly Pro Gly Glu Arg Lys 
        515                 520                 525             


Lys Met Val Lys Gly Val Pro Cys Cys Trp His Cys Glu Ala Cys Asp 
    530                 535                 540                 


Gly Tyr Arg Phe Gln Val Asp Glu Phe Thr Cys Glu Ala Cys Pro Gly 
545                 550                 555                 560 


Asp Met Arg Pro Thr Pro Asn His Thr Gly Cys Arg Pro Thr Pro Val 
                565                 570                 575     


Val Arg Leu Ser Trp Ser Ser Pro Trp Ala Ala Pro Pro Leu Leu Leu 
            580                 585                 590         


Ala Val Leu Gly Ile Val Ala Thr Thr Thr Val Val Ala Thr Phe Val 
        595                 600                 605             


Arg Tyr Asn Asn Thr Pro Ile Val Arg Ala Ser Gly Arg Glu Leu Ser 
    610                 615                 620                 


Tyr Val Leu Leu Thr Gly Ile Phe Leu Ile Tyr Ala Ile Thr Phe Leu 
625                 630                 635                 640 


Met Val Ala Glu Pro Gly Ala Ala Val Cys Ala Ala Arg Arg Leu Phe 
                645                 650                 655     


Leu Gly Leu Gly Thr Thr Leu Ser Tyr Ser Ala Leu Leu Thr Lys Thr 
            660                 665                 670         


Asn Arg Ile Tyr Arg Ile Phe Glu Gln Gly Lys Arg Ser Val Thr Pro 
        675                 680                 685             


Pro Pro Phe Ile Ser Pro Thr Ser Gln Leu Val Ile Thr Phe Ser Leu 
    690                 695                 700                 


Thr Ser Leu Gln Val Val Gly Met Ile Ala Trp Leu Gly Ala Arg Pro 
705                 710                 715                 720 


Pro His Ser Val Ile Asp Tyr Glu Glu Gln Arg Thr Val Asp Pro Glu 
                725                 730                 735     


Gln Ala Arg Gly Val Leu Lys Cys Asp Met Ser Asp Leu Ser Leu Ile 
            740                 745                 750         


Gly Cys Leu Gly Tyr Ser Leu Leu Leu Met Val Thr Cys Thr Val Tyr 
        755                 760                 765             


Ala Ile Lys Ala Arg Gly Val Pro Glu Thr Phe Asn Glu Ala Lys Pro 
    770                 775                 780                 


Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala Phe Val 
785                 790                 795                 800 


Pro Ile Phe Phe Gly Thr Ala Gln Ser Ala Glu Lys Ile Tyr Ile Gln 
                805                 810                 815     


Thr Thr Thr Leu Thr Val Ser Leu Ser Leu Ser Ala Ser Val Ser Leu 
            820                 825                 830         


Gly Met Leu Tyr Val Pro Lys Thr Tyr Val Ile Leu Phe His Pro Glu 
        835                 840                 845             


Gln Asn Val Gln Lys Arg Lys Arg Ser Leu Lys Ala Thr Ser Thr Val 
    850                 855                 860                 


Ala Ala Pro Pro Lys Gly Glu Asp Ala Glu Ala His Lys 
865                 870                 875         


<210>  294
<211>  915
<212>  PRT
<213>  Homo sapiens

<400>  294

Met Val Gln Leu Arg Lys Leu Leu Arg Val Leu Thr Leu Met Lys Phe 
1               5                   10                  15      


Pro Cys Cys Val Leu Glu Val Leu Leu Cys Ala Leu Ala Ala Ala Ala 
            20                  25                  30          


Arg Gly Gln Glu Met Tyr Ala Pro His Ser Ile Arg Ile Glu Gly Asp 
        35                  40                  45              


Val Thr Leu Gly Gly Leu Phe Pro Val His Ala Lys Gly Pro Ser Gly 
    50                  55                  60                  


Val Pro Cys Gly Asp Ile Lys Arg Glu Asn Gly Ile His Arg Leu Glu 
65                  70                  75                  80  


Ala Met Leu Tyr Ala Leu Asp Gln Ile Asn Ser Asp Pro Asn Leu Leu 
                85                  90                  95      


Pro Asn Val Thr Leu Gly Ala Arg Ile Leu Asp Thr Cys Ser Arg Asp 
            100                 105                 110         


Thr Tyr Ala Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Gln 
        115                 120                 125             


Lys Asp Thr Ser Asp Val Arg Cys Thr Asn Gly Glu Pro Pro Val Phe 
    130                 135                 140                 


Val Lys Pro Glu Lys Val Val Gly Val Ile Gly Ala Ser Gly Ser Ser 
145                 150                 155                 160 


Val Ser Ile Met Val Ala Asn Ile Leu Arg Leu Phe Gln Ile Pro Gln 
                165                 170                 175     


Ile Ser Tyr Ala Ser Thr Ala Pro Glu Leu Ser Asp Asp Arg Arg Tyr 
            180                 185                 190         


Asp Phe Phe Ser Arg Val Val Pro Pro Asp Ser Phe Gln Ala Gln Ala 
        195                 200                 205             


Met Val Asp Ile Val Lys Ala Leu Gly Trp Asn Tyr Val Ser Thr Leu 
    210                 215                 220                 


Ala Ser Glu Gly Ser Tyr Gly Glu Lys Gly Val Glu Ser Phe Thr Gln 
225                 230                 235                 240 


Ile Ser Lys Glu Ala Gly Gly Leu Cys Ile Ala Gln Ser Val Arg Ile 
                245                 250                 255     


Pro Gln Glu Arg Lys Asp Arg Thr Ile Asp Phe Asp Arg Ile Ile Lys 
            260                 265                 270         


Gln Leu Leu Asp Thr Pro Asn Ser Arg Ala Val Val Ile Phe Ala Asn 
        275                 280                 285             


Asp Glu Asp Ile Lys Gln Ile Leu Ala Ala Ala Lys Arg Ala Asp Gln 
    290                 295                 300                 


Val Gly His Phe Leu Trp Val Gly Ser Asp Ser Trp Gly Ser Lys Ile 
305                 310                 315                 320 


Asn Pro Leu His Gln His Glu Asp Ile Ala Glu Gly Ala Ile Thr Ile 
                325                 330                 335     


Gln Pro Lys Arg Ala Thr Val Glu Gly Phe Asp Ala Tyr Phe Thr Ser 
            340                 345                 350         


Arg Thr Leu Glu Asn Asn Arg Arg Asn Val Trp Phe Ala Glu Tyr Trp 
        355                 360                 365             


Glu Glu Asn Phe Asn Cys Lys Leu Thr Ile Ser Gly Ser Lys Lys Glu 
    370                 375                 380                 


Asp Thr Asp Arg Lys Cys Thr Gly Gln Glu Arg Ile Gly Lys Asp Ser 
385                 390                 395                 400 


Asn Tyr Glu Gln Glu Gly Lys Val Gln Phe Val Ile Asp Ala Val Tyr 
                405                 410                 415     


Ala Met Ala His Ala Leu His His Met Asn Lys Asp Leu Cys Ala Asp 
            420                 425                 430         


Tyr Arg Gly Val Cys Pro Glu Met Glu Gln Ala Gly Gly Lys Lys Leu 
        435                 440                 445             


Leu Lys Tyr Ile Arg Asn Val Asn Phe Asn Gly Ser Ala Gly Thr Pro 
    450                 455                 460                 


Val Met Phe Asn Lys Asn Gly Asp Ala Pro Gly Arg Tyr Asp Ile Phe 
465                 470                 475                 480 


Gln Tyr Gln Thr Thr Asn Thr Ser Asn Pro Gly Tyr Arg Leu Ile Gly 
                485                 490                 495     


Gln Trp Thr Asp Glu Leu Gln Leu Asn Ile Glu Asp Met Gln Trp Gly 
            500                 505                 510         


Lys Gly Val Arg Glu Ile Pro Ala Ser Val Cys Thr Leu Pro Cys Lys 
        515                 520                 525             


Pro Gly Gln Arg Lys Lys Thr Gln Lys Gly Thr Pro Cys Cys Trp Thr 
    530                 535                 540                 


Cys Glu Pro Cys Asp Gly Tyr Gln Tyr Gln Phe Asp Glu Met Thr Cys 
545                 550                 555                 560 


Gln His Cys Pro Tyr Asp Gln Arg Pro Asn Glu Asn Arg Thr Gly Cys 
                565                 570                 575     


Gln Asp Ile Pro Ile Ile Lys Leu Glu Trp His Ser Pro Trp Ala Val 
            580                 585                 590         


Ile Pro Val Phe Leu Ala Met Leu Gly Ile Ile Ala Thr Ile Phe Val 
        595                 600                 605             


Met Ala Thr Phe Ile Arg Tyr Asn Asp Thr Pro Ile Val Arg Ala Ser 
    610                 615                 620                 


Gly Arg Glu Leu Ser Tyr Val Leu Leu Thr Gly Ile Phe Leu Cys Tyr 
625                 630                 635                 640 


Ile Ile Thr Phe Leu Met Ile Ala Lys Pro Asp Val Ala Val Cys Ser 
                645                 650                 655     


Phe Arg Arg Val Phe Leu Gly Leu Gly Met Cys Ile Ser Tyr Ala Ala 
            660                 665                 670         


Leu Leu Thr Lys Thr Asn Arg Ile Tyr Arg Ile Phe Glu Gln Gly Lys 
        675                 680                 685             


Lys Ser Val Thr Ala Pro Arg Leu Ile Ser Pro Thr Ser Gln Leu Ala 
    690                 695                 700                 


Ile Thr Ser Ser Leu Ile Ser Val Gln Leu Leu Gly Val Phe Ile Trp 
705                 710                 715                 720 


Phe Gly Val Asp Pro Pro Asn Ile Ile Ile Asp Tyr Asp Glu His Lys 
                725                 730                 735     


Thr Met Asn Pro Glu Gln Ala Arg Gly Val Leu Lys Cys Asp Ile Thr 
            740                 745                 750         


Asp Leu Gln Ile Ile Cys Ser Leu Gly Tyr Ser Ile Leu Leu Met Val 
        755                 760                 765             


Thr Cys Thr Val Tyr Ala Ile Lys Thr Arg Gly Val Pro Glu Asn Phe 
    770                 775                 780                 


Asn Glu Ala Lys Pro Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Val 
785                 790                 795                 800 


Trp Leu Ala Phe Ile Pro Ile Phe Phe Gly Thr Ala Gln Ser Ala Glu 
                805                 810                 815     


Lys Leu Tyr Ile Gln Thr Thr Thr Leu Thr Ile Ser Met Asn Leu Ser 
            820                 825                 830         


Ala Ser Val Ala Leu Gly Met Leu Tyr Met Pro Lys Val Tyr Ile Ile 
        835                 840                 845             


Ile Phe His Pro Glu Leu Asn Val Gln Lys Arg Lys Arg Ser Phe Lys 
    850                 855                 860                 


Ala Val Val Thr Ala Ala Thr Met Ser Ser Arg Leu Ser His Lys Pro 
865                 870                 875                 880 


Ser Asp Arg Pro Asn Gly Glu Ala Lys Thr Glu Leu Cys Glu Asn Val 
                885                 890                 895     


Asp Pro Asn Ser Pro Ala Ala Lys Lys Lys Tyr Val Ser Tyr Asn Asn 
            900                 905                 910         


Leu Val Ile 
        915 


<210>  295
<211>  888
<212>  PRT
<213>  Homo sapiens

<400>  295

Met Leu Ser Arg Leu Phe Arg Met His Gly Leu Phe Val Ala Ser His 
1               5                   10                  15      


Pro Trp Glu Val Ile Val Gly Thr Val Thr Leu Thr Ile Cys Met Met 
            20                  25                  30          


Ser Met Asn Met Phe Thr Gly Asn Asn Lys Ile Cys Gly Trp Asn Tyr 
        35                  40                  45              


Glu Cys Pro Lys Phe Glu Glu Asp Val Leu Ser Ser Asp Ile Ile Ile 
    50                  55                  60                  


Leu Thr Ile Thr Arg Cys Ile Ala Ile Leu Tyr Ile Tyr Phe Gln Phe 
65                  70                  75                  80  


Gln Asn Leu Arg Gln Leu Gly Ser Lys Tyr Ile Leu Gly Ile Ala Gly 
                85                  90                  95      


Leu Phe Thr Ile Phe Ser Ser Phe Val Phe Ser Thr Val Val Ile His 
            100                 105                 110         


Phe Leu Asp Lys Glu Leu Thr Gly Leu Asn Glu Ala Leu Pro Phe Phe 
        115                 120                 125             


Leu Leu Leu Ile Asp Leu Ser Arg Ala Ser Thr Leu Ala Lys Phe Ala 
    130                 135                 140                 


Leu Ser Ser Asn Ser Gln Asp Glu Val Arg Glu Asn Ile Ala Arg Gly 
145                 150                 155                 160 


Met Ala Ile Leu Gly Pro Thr Phe Thr Leu Asp Ala Leu Val Glu Cys 
                165                 170                 175     


Leu Val Ile Gly Val Gly Thr Met Ser Gly Val Arg Gln Leu Glu Ile 
            180                 185                 190         


Met Cys Cys Phe Gly Cys Met Ser Val Leu Ala Asn Tyr Phe Val Phe 
        195                 200                 205             


Met Thr Phe Phe Pro Ala Cys Val Ser Leu Val Leu Glu Leu Ser Arg 
    210                 215                 220                 


Glu Ser Arg Glu Gly Arg Pro Ile Trp Gln Leu Ser His Phe Ala Arg 
225                 230                 235                 240 


Val Leu Glu Glu Glu Glu Asn Lys Pro Asn Pro Val Thr Gln Arg Val 
                245                 250                 255     


Lys Met Ile Met Ser Leu Gly Leu Val Leu Val His Ala His Ser Arg 
            260                 265                 270         


Trp Ile Ala Asp Pro Ser Pro Gln Asn Ser Thr Ala Asp Thr Ser Lys 
        275                 280                 285             


Val Ser Leu Gly Leu Asp Glu Asn Val Ser Lys Arg Ile Glu Pro Ser 
    290                 295                 300                 


Val Ser Leu Trp Gln Phe Tyr Leu Ser Lys Met Ile Ser Met Asp Ile 
305                 310                 315                 320 


Glu Gln Val Ile Thr Leu Ser Leu Ala Leu Leu Leu Ala Val Lys Tyr 
                325                 330                 335     


Ile Phe Phe Glu Gln Thr Glu Thr Glu Ser Thr Leu Ser Leu Lys Asn 
            340                 345                 350         


Pro Ile Thr Ser Pro Val Val Thr Gln Lys Lys Val Pro Asp Asn Cys 
        355                 360                 365             


Cys Arg Arg Glu Pro Met Leu Val Arg Asn Asn Gln Lys Cys Asp Ser 
    370                 375                 380                 


Val Glu Glu Glu Thr Gly Ile Asn Arg Glu Arg Lys Val Glu Val Ile 
385                 390                 395                 400 


Lys Pro Leu Val Ala Glu Thr Asp Thr Pro Asn Arg Ala Thr Phe Val 
                405                 410                 415     


Val Gly Asn Ser Ser Leu Leu Asp Thr Ser Ser Val Leu Val Thr Gln 
            420                 425                 430         


Glu Pro Glu Ile Glu Leu Pro Arg Glu Pro Arg Pro Asn Glu Glu Cys 
        435                 440                 445             


Leu Gln Ile Leu Gly Asn Ala Glu Lys Gly Ala Lys Phe Leu Ser Asp 
    450                 455                 460                 


Ala Glu Ile Ile Gln Leu Val Asn Ala Lys His Ile Pro Ala Tyr Lys 
465                 470                 475                 480 


Leu Glu Thr Leu Met Glu Thr His Glu Arg Gly Val Ser Ile Arg Arg 
                485                 490                 495     


Gln Leu Leu Ser Lys Lys Leu Ser Glu Pro Ser Ser Leu Gln Tyr Leu 
            500                 505                 510         


Pro Tyr Arg Asp Tyr Asn Tyr Ser Leu Val Met Gly Ala Cys Cys Glu 
        515                 520                 525             


Asn Val Ile Gly Tyr Met Pro Ile Pro Val Gly Val Ala Gly Pro Leu 
    530                 535                 540                 


Cys Leu Asp Glu Lys Glu Phe Gln Val Pro Met Ala Thr Thr Glu Gly 
545                 550                 555                 560 


Cys Leu Val Ala Ser Thr Asn Arg Gly Cys Arg Ala Ile Gly Leu Gly 
                565                 570                 575     


Gly Gly Ala Ser Ser Arg Val Leu Ala Asp Gly Met Thr Arg Gly Pro 
            580                 585                 590         


Val Val Arg Leu Pro Arg Ala Cys Asp Ser Ala Glu Val Lys Ala Trp 
        595                 600                 605             


Leu Glu Thr Ser Glu Gly Phe Ala Val Ile Lys Glu Ala Phe Asp Ser 
    610                 615                 620                 


Thr Ser Arg Phe Ala Arg Leu Gln Lys Leu His Thr Ser Ile Ala Gly 
625                 630                 635                 640 


Arg Asn Leu Tyr Ile Arg Phe Gln Ser Arg Ser Gly Asp Ala Met Gly 
                645                 650                 655     


Met Asn Met Ile Ser Lys Gly Thr Glu Lys Ala Leu Ser Lys Leu His 
            660                 665                 670         


Glu Tyr Phe Pro Glu Met Gln Ile Leu Ala Val Ser Gly Asn Tyr Cys 
        675                 680                 685             


Thr Asp Lys Lys Pro Ala Ala Ile Asn Trp Ile Glu Gly Arg Gly Lys 
    690                 695                 700                 


Ser Val Val Cys Glu Ala Val Ile Pro Ala Lys Val Val Arg Glu Val 
705                 710                 715                 720 


Leu Lys Thr Thr Thr Glu Ala Met Ile Glu Val Asn Ile Asn Lys Asn 
                725                 730                 735     


Leu Val Gly Ser Ala Met Ala Gly Ser Ile Gly Gly Tyr Asn Ala His 
            740                 745                 750         


Ala Ala Asn Ile Val Thr Ala Ile Tyr Ile Ala Cys Gly Gln Asp Ala 
        755                 760                 765             


Ala Gln Asn Val Gly Ser Ser Asn Cys Ile Thr Leu Met Glu Ala Ser 
    770                 775                 780                 


Gly Pro Thr Asn Glu Asp Leu Tyr Ile Ser Cys Thr Met Pro Ser Ile 
785                 790                 795                 800 


Glu Ile Gly Thr Val Gly Gly Gly Thr Asn Leu Leu Pro Gln Gln Ala 
                805                 810                 815     


Cys Leu Gln Met Leu Gly Val Gln Gly Ala Cys Lys Asp Asn Pro Gly 
            820                 825                 830         


Glu Asn Ala Arg Gln Leu Ala Arg Ile Val Cys Gly Thr Val Met Ala 
        835                 840                 845             


Gly Glu Leu Ser Leu Met Ala Ala Leu Ala Ala Gly His Leu Val Lys 
    850                 855                 860                 


Ser His Met Ile His Asn Arg Ser Lys Ile Asn Leu Gln Asp Leu Gln 
865                 870                 875                 880 


Gly Ala Cys Thr Lys Lys Thr Ala 
                885             


<210>  296
<211>  487
<212>  PRT
<213>  Homo sapiens

<400>  296

Met Ser Leu Pro Asn Ser Ser Cys Leu Leu Glu Asp Lys Met Cys Glu 
1               5                   10                  15      


Gly Asn Lys Thr Thr Met Ala Ser Pro Gln Leu Met Pro Leu Val Val 
            20                  25                  30          


Val Leu Ser Thr Ile Cys Leu Val Thr Val Gly Leu Asn Leu Leu Val 
        35                  40                  45              


Leu Tyr Ala Val Arg Ser Glu Arg Lys Leu His Thr Val Gly Asn Leu 
    50                  55                  60                  


Tyr Ile Val Ser Leu Ser Val Ala Asp Leu Ile Val Gly Ala Val Val 
65                  70                  75                  80  


Met Pro Met Asn Ile Leu Tyr Leu Leu Met Ser Lys Trp Ser Leu Gly 
                85                  90                  95      


Arg Pro Leu Cys Leu Phe Trp Leu Ser Met Asp Tyr Val Ala Ser Thr 
            100                 105                 110         


Ala Ser Ile Phe Ser Val Phe Ile Leu Cys Ile Asp Arg Tyr Arg Ser 
        115                 120                 125             


Val Gln Gln Pro Leu Arg Tyr Leu Lys Tyr Arg Thr Lys Thr Arg Ala 
    130                 135                 140                 


Ser Ala Thr Ile Leu Gly Ala Trp Phe Leu Ser Phe Leu Trp Val Ile 
145                 150                 155                 160 


Pro Ile Leu Gly Trp Asn His Phe Met Gln Gln Thr Ser Val Arg Arg 
                165                 170                 175     


Glu Asp Lys Cys Glu Thr Asp Phe Tyr Asp Val Thr Trp Phe Lys Val 
            180                 185                 190         


Met Thr Ala Ile Ile Asn Phe Tyr Leu Pro Thr Leu Leu Met Leu Trp 
        195                 200                 205             


Phe Tyr Ala Lys Ile Tyr Lys Ala Val Arg Gln His Cys Gln His Arg 
    210                 215                 220                 


Glu Leu Ile Asn Arg Ser Leu Pro Ser Phe Ser Glu Ile Lys Leu Arg 
225                 230                 235                 240 


Pro Glu Asn Pro Lys Gly Asp Ala Lys Lys Pro Gly Lys Glu Ser Pro 
                245                 250                 255     


Trp Glu Val Leu Lys Arg Lys Pro Lys Asp Ala Gly Gly Gly Ser Val 
            260                 265                 270         


Leu Lys Ser Pro Ser Gln Thr Pro Lys Glu Met Lys Ser Pro Val Val 
        275                 280                 285             


Phe Ser Gln Glu Asp Asp Arg Glu Val Asp Lys Leu Tyr Cys Phe Pro 
    290                 295                 300                 


Leu Asp Ile Val His Met Gln Ala Ala Ala Glu Gly Ser Ser Arg Asp 
305                 310                 315                 320 


Tyr Val Ala Val Asn Arg Ser His Gly Gln Leu Lys Thr Asp Glu Gln 
                325                 330                 335     


Gly Leu Asn Thr His Gly Ala Ser Glu Ile Ser Glu Asp Gln Met Leu 
            340                 345                 350         


Gly Asp Ser Gln Ser Phe Ser Arg Thr Asp Ser Asp Thr Thr Thr Glu 
        355                 360                 365             


Thr Ala Pro Gly Lys Gly Lys Leu Arg Ser Gly Ser Asn Thr Gly Leu 
    370                 375                 380                 


Asp Tyr Ile Lys Phe Thr Trp Lys Arg Leu Arg Ser His Ser Arg Gln 
385                 390                 395                 400 


Tyr Val Ser Gly Leu His Met Asn Arg Glu Arg Lys Ala Ala Lys Gln 
                405                 410                 415     


Leu Gly Phe Ile Met Ala Ala Phe Ile Leu Cys Trp Ile Pro Tyr Phe 
            420                 425                 430         


Ile Phe Phe Met Val Ile Ala Phe Cys Lys Asn Cys Cys Asn Glu His 
        435                 440                 445             


Leu His Met Phe Thr Ile Trp Leu Gly Tyr Ile Asn Ser Thr Leu Asn 
    450                 455                 460                 


Pro Leu Ile Tyr Pro Leu Cys Asn Glu Asn Phe Lys Lys Thr Phe Lys 
465                 470                 475                 480 


Arg Ile Leu His Ile Arg Ser 
                485         


<210>  297
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  297

Met Glu Glu Pro Gly Ala Gln Cys Ala Pro Pro Pro Pro Ala Gly Ser 
1               5                   10                  15      


Glu Thr Trp Val Pro Gln Ala Asn Leu Ser Ser Ala Pro Ser Gln Asn 
            20                  25                  30          


Cys Ser Ala Lys Asp Tyr Ile Tyr Gln Asp Ser Ile Ser Leu Pro Trp 
        35                  40                  45              


Lys Val Leu Leu Val Met Leu Leu Ala Leu Ile Thr Leu Ala Thr Thr 
    50                  55                  60                  


Leu Ser Asn Ala Phe Val Ile Ala Thr Val Tyr Arg Thr Arg Lys Leu 
65                  70                  75                  80  


His Thr Pro Ala Asn Tyr Leu Ile Ala Ser Leu Ala Val Thr Asp Leu 
                85                  90                  95      


Leu Val Ser Ile Leu Val Met Pro Ile Ser Thr Met Tyr Thr Val Thr 
            100                 105                 110         


Gly Arg Trp Thr Leu Gly Gln Val Val Cys Asp Phe Trp Leu Ser Ser 
        115                 120                 125             


Asp Ile Thr Cys Cys Thr Ala Ser Ile Leu His Leu Cys Val Ile Ala 
    130                 135                 140                 


Leu Asp Arg Tyr Trp Ala Ile Thr Asp Ala Val Glu Tyr Ser Ala Lys 
145                 150                 155                 160 


Arg Thr Pro Lys Arg Ala Ala Val Met Ile Ala Leu Val Trp Val Phe 
                165                 170                 175     


Ser Ile Ser Ile Ser Leu Pro Pro Phe Phe Trp Arg Gln Ala Lys Ala 
            180                 185                 190         


Glu Glu Glu Val Ser Glu Cys Val Val Asn Thr Asp His Ile Leu Tyr 
        195                 200                 205             


Thr Val Tyr Ser Thr Val Gly Ala Phe Tyr Phe Pro Thr Leu Leu Leu 
    210                 215                 220                 


Ile Ala Leu Tyr Gly Arg Ile Tyr Val Glu Ala Arg Ser Arg Ile Leu 
225                 230                 235                 240 


Lys Gln Thr Pro Asn Arg Thr Gly Lys Arg Leu Thr Arg Ala Gln Leu 
                245                 250                 255     


Ile Thr Asp Ser Pro Gly Ser Thr Ser Ser Val Thr Ser Ile Asn Ser 
            260                 265                 270         


Arg Val Pro Asp Val Pro Ser Glu Ser Gly Ser Pro Val Tyr Val Asn 
        275                 280                 285             


Gln Val Lys Val Arg Val Ser Asp Ala Leu Leu Glu Lys Lys Lys Leu 
    290                 295                 300                 


Met Ala Ala Arg Glu Arg Lys Ala Thr Lys Thr Leu Gly Ile Ile Leu 
305                 310                 315                 320 


Gly Ala Phe Ile Val Cys Trp Leu Pro Phe Phe Ile Ile Ser Leu Val 
                325                 330                 335     


Met Pro Ile Cys Lys Asp Ala Cys Trp Phe His Leu Ala Ile Phe Asp 
            340                 345                 350         


Phe Phe Thr Trp Leu Gly Tyr Leu Asn Ser Leu Ile Asn Pro Ile Ile 
        355                 360                 365             


Tyr Thr Met Ser Asn Glu Asp Phe Lys Gln Ala Phe His Lys Leu Ile 
    370                 375                 380                 


Arg Phe Lys Cys Thr Ser 
385                 390 


<210>  298
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  298

Met Ser Pro Leu Asn Gln Ser Ala Glu Gly Leu Pro Gln Glu Ala Ser 
1               5                   10                  15      


Asn Arg Ser Leu Asn Ala Thr Glu Thr Ser Glu Ala Trp Asp Pro Arg 
            20                  25                  30          


Thr Leu Gln Ala Leu Lys Ile Ser Leu Ala Val Val Leu Ser Val Ile 
        35                  40                  45              


Thr Leu Ala Thr Val Leu Ser Asn Ala Phe Val Leu Thr Thr Ile Leu 
    50                  55                  60                  


Leu Thr Arg Lys Leu His Thr Pro Ala Asn Tyr Leu Ile Gly Ser Leu 
65                  70                  75                  80  


Ala Thr Thr Asp Leu Leu Val Ser Ile Leu Val Met Pro Ile Ser Ile 
                85                  90                  95      


Ala Tyr Thr Ile Thr His Thr Trp Asn Phe Gly Gln Ile Leu Cys Asp 
            100                 105                 110         


Ile Trp Leu Ser Ser Asp Ile Thr Cys Cys Thr Ala Ser Ile Leu His 
        115                 120                 125             


Leu Cys Val Ile Ala Leu Asp Arg Tyr Trp Ala Ile Thr Asp Ala Leu 
    130                 135                 140                 


Glu Tyr Ser Lys Arg Arg Thr Ala Gly His Ala Ala Thr Met Ile Ala 
145                 150                 155                 160 


Ile Val Trp Ala Ile Ser Ile Cys Ile Ser Ile Pro Pro Leu Phe Trp 
                165                 170                 175     


Arg Gln Ala Lys Ala Gln Glu Glu Met Ser Asp Cys Leu Val Asn Thr 
            180                 185                 190         


Ser Gln Ile Ser Tyr Thr Ile Tyr Ser Thr Cys Gly Ala Phe Tyr Ile 
        195                 200                 205             


Pro Ser Val Leu Leu Ile Ile Leu Tyr Gly Arg Ile Tyr Arg Ala Ala 
    210                 215                 220                 


Arg Asn Arg Ile Leu Asn Pro Pro Ser Leu Tyr Gly Lys Arg Phe Thr 
225                 230                 235                 240 


Thr Ala His Leu Ile Thr Gly Ser Ala Gly Ser Ser Leu Cys Ser Leu 
                245                 250                 255     


Asn Ser Ser Leu His Glu Gly His Ser His Ser Ala Gly Ser Pro Leu 
            260                 265                 270         


Phe Phe Asn His Val Lys Ile Lys Leu Ala Asp Ser Ala Leu Glu Arg 
        275                 280                 285             


Lys Arg Ile Ser Ala Ala Arg Glu Arg Lys Ala Thr Lys Ile Leu Gly 
    290                 295                 300                 


Ile Ile Leu Gly Ala Phe Ile Ile Cys Trp Leu Pro Phe Phe Val Val 
305                 310                 315                 320 


Ser Leu Val Leu Pro Ile Cys Arg Asp Ser Cys Trp Ile His Pro Ala 
                325                 330                 335     


Leu Phe Asp Phe Phe Thr Trp Leu Gly Tyr Leu Asn Ser Leu Ile Asn 
            340                 345                 350         


Pro Ile Ile Tyr Thr Val Phe Asn Glu Glu Phe Arg Gln Ala Phe Gln 
        355                 360                 365             


Lys Ile Val Pro Phe Arg Lys Ala Ser 
    370                 375         


<210>  299
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  299

Met Asp Phe Leu Asn Ser Ser Asp Gln Asn Leu Thr Ser Glu Glu Leu 
1               5                   10                  15      


Leu Asn Arg Met Pro Ser Lys Ile Leu Val Ser Leu Thr Leu Ser Gly 
            20                  25                  30          


Leu Ala Leu Met Thr Thr Thr Ile Asn Ser Leu Val Ile Ala Ala Ile 
        35                  40                  45              


Ile Val Thr Arg Lys Leu His His Pro Ala Asn Tyr Leu Ile Cys Ser 
    50                  55                  60                  


Leu Ala Val Thr Asp Phe Leu Val Ala Val Leu Val Met Pro Phe Ser 
65                  70                  75                  80  


Ile Val Tyr Ile Val Arg Glu Ser Trp Ile Met Gly Gln Val Val Cys 
                85                  90                  95      


Asp Ile Trp Leu Ser Val Asp Ile Thr Cys Cys Thr Cys Ser Ile Leu 
            100                 105                 110         


His Leu Ser Ala Ile Ala Leu Asp Arg Tyr Arg Ala Ile Thr Asp Ala 
        115                 120                 125             


Val Glu Tyr Ala Arg Lys Arg Thr Pro Lys His Ala Gly Ile Met Ile 
    130                 135                 140                 


Thr Ile Val Trp Ile Ile Ser Val Phe Ile Ser Met Pro Pro Leu Phe 
145                 150                 155                 160 


Trp Arg His Gln Gly Thr Ser Arg Asp Asp Glu Cys Ile Ile Lys His 
                165                 170                 175     


Asp His Ile Val Ser Thr Ile Tyr Ser Thr Phe Gly Ala Phe Tyr Ile 
            180                 185                 190         


Pro Leu Ala Leu Ile Leu Ile Leu Tyr Tyr Lys Ile Tyr Arg Ala Ala 
        195                 200                 205             


Lys Thr Leu Tyr His Lys Arg Gln Ala Ser Arg Ile Ala Lys Glu Glu 
    210                 215                 220                 


Val Asn Gly Gln Val Leu Leu Glu Ser Gly Glu Lys Ser Thr Lys Ser 
225                 230                 235                 240 


Val Ser Thr Ser Tyr Val Leu Glu Lys Ser Leu Ser Asp Pro Ser Thr 
                245                 250                 255     


Asp Phe Asp Lys Ile His Ser Thr Val Arg Ser Leu Arg Ser Glu Phe 
            260                 265                 270         


Lys His Glu Lys Ser Trp Arg Arg Gln Lys Ile Ser Gly Thr Arg Glu 
        275                 280                 285             


Arg Lys Ala Ala Thr Thr Leu Gly Leu Ile Leu Gly Ala Phe Val Ile 
    290                 295                 300                 


Cys Trp Leu Pro Phe Phe Val Lys Glu Leu Val Val Asn Val Cys Asp 
305                 310                 315                 320 


Lys Cys Lys Ile Ser Glu Glu Met Ser Asn Phe Leu Ala Trp Leu Gly 
                325                 330                 335     


Tyr Leu Asn Ser Leu Ile Asn Pro Leu Ile Tyr Thr Ile Phe Asn Glu 
            340                 345                 350         


Asp Phe Lys Lys Ala Phe Gln Lys Leu Val Arg Cys Arg Cys 
        355                 360                 365     


<210>  300
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  300

Met Ala Leu Ser Tyr Arg Val Ser Glu Leu Gln Ser Thr Ile Pro Glu 
1               5                   10                  15      


His Ile Leu Gln Ser Thr Phe Val His Val Ile Ser Ser Asn Trp Ser 
            20                  25                  30          


Gly Leu Gln Thr Glu Ser Ile Pro Glu Glu Met Lys Gln Ile Val Glu 
        35                  40                  45              


Glu Gln Gly Asn Lys Leu His Trp Ala Ala Leu Leu Ile Leu Met Val 
    50                  55                  60                  


Ile Ile Pro Thr Ile Gly Gly Asn Thr Leu Val Ile Leu Ala Val Ser 
65                  70                  75                  80  


Leu Glu Lys Lys Leu Gln Tyr Ala Thr Asn Tyr Phe Leu Met Ser Leu 
                85                  90                  95      


Ala Val Ala Asp Leu Leu Val Gly Leu Phe Val Met Pro Ile Ala Leu 
            100                 105                 110         


Leu Thr Ile Met Phe Glu Ala Met Trp Pro Leu Pro Leu Val Leu Cys 
        115                 120                 125             


Pro Ala Trp Leu Phe Leu Asp Val Leu Phe Ser Thr Ala Ser Ile Met 
    130                 135                 140                 


His Leu Cys Ala Ile Ser Val Asp Arg Tyr Ile Ala Ile Lys Lys Pro 
145                 150                 155                 160 


Ile Gln Ala Asn Gln Tyr Asn Ser Arg Ala Thr Ala Phe Ile Lys Ile 
                165                 170                 175     


Thr Val Val Trp Leu Ile Ser Ile Gly Ile Ala Ile Pro Val Pro Ile 
            180                 185                 190         


Lys Gly Ile Glu Thr Asp Val Asp Asn Pro Asn Asn Ile Thr Cys Val 
        195                 200                 205             


Leu Thr Lys Glu Arg Phe Gly Asp Phe Met Leu Phe Gly Ser Leu Ala 
    210                 215                 220                 


Ala Phe Phe Thr Pro Leu Ala Ile Met Ile Val Thr Tyr Phe Leu Thr 
225                 230                 235                 240 


Ile His Ala Leu Gln Lys Lys Ala Tyr Leu Val Lys Asn Lys Pro Pro 
                245                 250                 255     


Gln Arg Leu Thr Trp Leu Thr Val Ser Thr Val Phe Gln Arg Asp Glu 
            260                 265                 270         


Thr Pro Cys Ser Ser Pro Glu Lys Val Ala Met Leu Asp Gly Ser Arg 
        275                 280                 285             


Lys Asp Lys Ala Leu Pro Asn Ser Gly Asp Glu Thr Leu Met Arg Arg 
    290                 295                 300                 


Thr Ser Thr Ile Gly Lys Lys Ser Val Gln Thr Ile Ser Asn Glu Gln 
305                 310                 315                 320 


Arg Ala Ser Lys Val Leu Gly Ile Val Phe Phe Leu Phe Leu Leu Met 
                325                 330                 335     


Trp Cys Pro Phe Phe Ile Thr Asn Ile Thr Leu Val Leu Cys Asp Ser 
            340                 345                 350         


Cys Asn Gln Thr Thr Leu Gln Met Leu Leu Glu Ile Phe Val Trp Ile 
        355                 360                 365             


Gly Tyr Val Ser Ser Gly Val Asn Pro Leu Val Tyr Thr Leu Phe Asn 
    370                 375                 380                 


Lys Thr Phe Arg Asp Ala Phe Gly Arg Tyr Ile Thr Cys Asn Tyr Arg 
385                 390                 395                 400 


Ala Thr Lys Ser Val Lys Thr Leu Arg Lys Arg Ser Ser Lys Ile Tyr 
                405                 410                 415     


Phe Arg Asn Pro Met Ala Glu Asn Ser Lys Phe Phe Lys Lys His Gly 
            420                 425                 430         


Ile Arg Asn Gly Ile Asn Pro Ala Met Tyr Gln Ser Pro Met Arg Leu 
        435                 440                 445             


Arg Ser Ser Thr Ile Gln Ser Ser Ser Ile Ile Leu Leu Asp Thr Leu 
    450                 455                 460                 


Leu Leu Thr Glu Asn Glu Gly Asp Lys Thr Glu Glu Gln Val Ser Tyr 
465                 470                 475                 480 


Val 
    


<210>  301
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  301

Met Val Asn Leu Arg Asn Ala Val His Ser Phe Leu Val His Leu Ile 
1               5                   10                  15      


Gly Leu Leu Val Trp Gln Cys Asp Ile Ser Val Ser Pro Val Ala Ala 
            20                  25                  30          


Ile Val Thr Asp Ile Phe Asn Thr Ser Asp Gly Gly Arg Phe Lys Phe 
        35                  40                  45              


Pro Asp Gly Val Gln Asn Trp Pro Ala Leu Ser Ile Val Ile Ile Ile 
    50                  55                  60                  


Ile Met Thr Ile Gly Gly Asn Ile Leu Val Ile Met Ala Val Ser Met 
65                  70                  75                  80  


Glu Lys Lys Leu His Asn Ala Thr Asn Tyr Phe Leu Met Ser Leu Ala 
                85                  90                  95      


Ile Ala Asp Met Leu Val Gly Leu Leu Val Met Pro Leu Ser Leu Leu 
            100                 105                 110         


Ala Ile Leu Tyr Asp Tyr Val Trp Pro Leu Pro Arg Tyr Leu Cys Pro 
        115                 120                 125             


Val Trp Ile Ser Leu Asp Val Leu Phe Ser Thr Ala Ser Ile Met His 
    130                 135                 140                 


Leu Cys Ala Ile Ser Leu Asp Arg Tyr Val Ala Ile Arg Asn Pro Ile 
145                 150                 155                 160 


Glu His Ser Arg Phe Asn Ser Arg Thr Lys Ala Ile Met Lys Ile Ala 
                165                 170                 175     


Ile Val Trp Ala Ile Ser Ile Gly Val Ser Val Pro Ile Pro Val Ile 
            180                 185                 190         


Gly Leu Arg Asp Glu Glu Lys Val Phe Val Asn Asn Thr Thr Cys Val 
        195                 200                 205             


Leu Asn Asp Pro Asn Phe Val Leu Ile Gly Ser Phe Val Ala Phe Phe 
    210                 215                 220                 


Ile Pro Leu Thr Ile Met Val Ile Thr Tyr Cys Leu Thr Ile Tyr Val 
225                 230                 235                 240 


Leu Arg Arg Gln Ala Leu Met Leu Leu His Gly His Thr Glu Glu Pro 
                245                 250                 255     


Pro Gly Leu Ser Leu Asp Phe Leu Lys Cys Cys Lys Arg Asn Thr Ala 
            260                 265                 270         


Glu Glu Glu Asn Ser Ala Asn Pro Asn Gln Asp Gln Asn Ala Arg Arg 
        275                 280                 285             


Arg Lys Lys Lys Glu Arg Arg Pro Arg Gly Thr Met Gln Ala Ile Asn 
    290                 295                 300                 


Asn Glu Arg Lys Ala Ser Lys Val Leu Gly Ile Val Phe Phe Val Phe 
305                 310                 315                 320 


Leu Ile Met Trp Cys Pro Phe Phe Ile Thr Asn Ile Leu Ser Val Leu 
                325                 330                 335     


Cys Glu Lys Ser Cys Asn Gln Lys Leu Met Glu Lys Leu Leu Asn Val 
            340                 345                 350         


Phe Val Trp Ile Gly Tyr Val Cys Ser Gly Ile Asn Pro Leu Val Tyr 
        355                 360                 365             


Thr Leu Phe Asn Lys Ile Tyr Arg Arg Ala Phe Ser Asn Tyr Leu Arg 
    370                 375                 380                 


Cys Asn Tyr Lys Val Glu Lys Lys Pro Pro Val Arg Gln Ile Pro Arg 
385                 390                 395                 400 


Val Ala Ala Thr Ala Leu Ser Gly Arg Glu Leu Asn Val Asn Ile Tyr 
                405                 410                 415     


Arg His Thr Asn Glu Pro Val Ile Glu Lys Ala Ser Asp Asn Glu Pro 
            420                 425                 430         


Gly Ile Glu Met Gln Val Glu Asn Leu Glu Leu Pro Val Asn Pro Ser 
        435                 440                 445             


Ser Val Val Ser Glu Arg Ile Ser Ser Val 
    450                 455             


<210>  302
<211>  484
<212>  PRT
<213>  Homo sapiens

<400>  302

Met Leu Gly Lys Leu Ala Met Leu Leu Trp Val Gln Gln Ala Leu Leu 
1               5                   10                  15      


Ala Leu Leu Leu Pro Thr Leu Leu Ala Gln Gly Glu Ala Arg Arg Ser 
            20                  25                  30          


Arg Asn Thr Thr Arg Pro Ala Leu Leu Arg Leu Ser Asp Tyr Leu Leu 
        35                  40                  45              


Thr Asn Tyr Arg Lys Gly Val Arg Pro Val Arg Asp Trp Arg Lys Pro 
    50                  55                  60                  


Thr Thr Val Ser Ile Asp Val Ile Val Tyr Ala Ile Leu Asn Val Asp 
65                  70                  75                  80  


Glu Lys Asn Gln Val Leu Thr Thr Tyr Ile Trp Tyr Arg Gln Tyr Trp 
                85                  90                  95      


Thr Asp Glu Phe Leu Gln Trp Asn Pro Glu Asp Phe Asp Asn Ile Thr 
            100                 105                 110         


Lys Leu Ser Ile Pro Thr Asp Ser Ile Trp Val Pro Asp Ile Leu Ile 
        115                 120                 125             


Asn Glu Phe Val Asp Val Gly Lys Ser Pro Asn Ile Pro Tyr Val Tyr 
    130                 135                 140                 


Ile Arg His Gln Gly Glu Val Gln Asn Tyr Lys Pro Leu Gln Val Val 
145                 150                 155                 160 


Thr Ala Cys Ser Leu Asp Ile Tyr Asn Phe Pro Phe Asp Val Gln Asn 
                165                 170                 175     


Cys Ser Leu Thr Phe Thr Ser Trp Leu His Thr Ile Gln Asp Ile Asn 
            180                 185                 190         


Ile Ser Leu Trp Arg Leu Pro Glu Lys Val Lys Ser Asp Arg Ser Val 
        195                 200                 205             


Phe Met Asn Gln Gly Glu Trp Glu Leu Leu Gly Val Leu Pro Tyr Phe 
    210                 215                 220                 


Arg Glu Phe Ser Met Glu Ser Ser Asn Tyr Tyr Ala Glu Met Lys Phe 
225                 230                 235                 240 


Tyr Val Val Ile Arg Arg Arg Pro Leu Phe Tyr Val Val Ser Leu Leu 
                245                 250                 255     


Leu Pro Ser Ile Phe Leu Met Val Met Asp Ile Val Gly Phe Tyr Leu 
            260                 265                 270         


Pro Pro Asn Ser Gly Glu Arg Val Ser Phe Lys Ile Thr Leu Leu Leu 
        275                 280                 285             


Gly Tyr Ser Val Phe Leu Ile Ile Val Ser Asp Thr Leu Pro Ala Thr 
    290                 295                 300                 


Ala Ile Gly Thr Pro Leu Ile Gly Val Tyr Phe Val Val Cys Met Ala 
305                 310                 315                 320 


Leu Leu Val Ile Ser Leu Ala Glu Thr Ile Phe Ile Val Arg Leu Val 
                325                 330                 335     


His Lys Gln Asp Leu Gln Gln Pro Val Pro Ala Trp Leu Arg His Leu 
            340                 345                 350         


Val Leu Glu Arg Ile Ala Trp Leu Leu Cys Leu Arg Glu Gln Ser Thr 
        355                 360                 365             


Ser Gln Arg Pro Pro Ala Thr Ser Gln Ala Thr Lys Thr Asp Asp Cys 
    370                 375                 380                 


Ser Ala Met Gly Asn His Cys Ser His Met Gly Gly Pro Gln Asp Phe 
385                 390                 395                 400 


Glu Lys Ser Pro Arg Asp Arg Cys Ser Pro Pro Pro Pro Pro Arg Glu 
                405                 410                 415     


Ala Ser Leu Ala Val Cys Gly Leu Leu Gln Glu Leu Ser Ser Ile Arg 
            420                 425                 430         


Gln Phe Leu Glu Lys Arg Asp Glu Ile Arg Glu Val Ala Arg Asp Trp 
        435                 440                 445             


Leu Arg Val Gly Ser Val Leu Asp Lys Leu Leu Phe His Ile Tyr Leu 
    450                 455                 460                 


Leu Ala Val Leu Ala Tyr Ser Ile Thr Leu Val Met Leu Trp Ser Ile 
465                 470                 475                 480 


Trp Gln Tyr Ala 
                


<210>  303
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  303

Met Asp Lys Leu Asp Ala Asn Val Ser Ser Glu Glu Gly Phe Gly Ser 
1               5                   10                  15      


Val Glu Lys Val Val Leu Leu Thr Phe Leu Ser Thr Val Ile Leu Met 
            20                  25                  30          


Ala Ile Leu Gly Asn Leu Leu Val Met Val Ala Val Cys Trp Asp Arg 
        35                  40                  45              


Gln Leu Arg Lys Ile Lys Thr Asn Tyr Phe Ile Val Ser Leu Ala Phe 
    50                  55                  60                  


Ala Asp Leu Leu Val Ser Val Leu Val Met Pro Phe Gly Ala Ile Glu 
65                  70                  75                  80  


Leu Val Gln Asp Ile Trp Ile Tyr Gly Glu Val Phe Cys Leu Val Arg 
                85                  90                  95      


Thr Ser Leu Asp Val Leu Leu Thr Thr Ala Ser Ile Phe His Leu Cys 
            100                 105                 110         


Cys Ile Ser Leu Asp Arg Tyr Tyr Ala Ile Cys Cys Gln Pro Leu Val 
        115                 120                 125             


Tyr Arg Asn Lys Met Thr Pro Leu Arg Ile Ala Leu Met Leu Gly Gly 
    130                 135                 140                 


Cys Trp Val Ile Pro Thr Phe Ile Ser Phe Leu Pro Ile Met Gln Gly 
145                 150                 155                 160 


Trp Asn Asn Ile Gly Ile Ile Asp Leu Ile Glu Lys Arg Lys Phe Asn 
                165                 170                 175     


Gln Asn Ser Asn Ser Thr Tyr Cys Val Phe Met Val Asn Lys Pro Tyr 
            180                 185                 190         


Ala Ile Thr Cys Ser Val Val Ala Phe Tyr Ile Pro Phe Leu Leu Met 
        195                 200                 205             


Val Leu Ala Tyr Tyr Arg Ile Tyr Val Thr Ala Lys Glu His Ala His 
    210                 215                 220                 


Gln Ile Gln Met Leu Gln Arg Ala Gly Ala Ser Ser Glu Ser Arg Pro 
225                 230                 235                 240 


Gln Ser Ala Asp Gln His Ser Thr His Arg Met Arg Thr Glu Thr Lys 
                245                 250                 255     


Ala Ala Lys Thr Leu Cys Ile Ile Met Gly Cys Phe Cys Leu Cys Trp 
            260                 265                 270         


Ala Pro Phe Phe Val Thr Asn Ile Val Asp Pro Phe Ile Asp Tyr Thr 
        275                 280                 285             


Val Pro Gly Gln Val Trp Thr Ala Phe Leu Trp Leu Gly Tyr Ile Asn 
    290                 295                 300                 


Ser Gly Leu Asn Pro Phe Leu Tyr Ala Phe Leu Asn Lys Ser Phe Arg 
305                 310                 315                 320 


Arg Ala Phe Leu Ile Ile Leu Cys Cys Asp Asp Glu Arg Tyr Arg Arg 
                325                 330                 335     


Pro Ser Ile Leu Gly Gln Thr Val Pro Cys Ser Thr Thr Thr Ile Asn 
            340                 345                 350         


Gly Ser Thr His Val Leu Arg Asp Ala Val Glu Cys Gly Gly Gln Trp 
        355                 360                 365             


Glu Ser Gln Cys His Pro Pro Ala Thr Ser Pro Leu Val Ala Ala Gln 
    370                 375                 380                 


Pro Ser Asp Thr 
385             


<210>  304
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  304

Met Val Pro Glu Pro Gly Pro Thr Ala Asn Ser Thr Pro Ala Trp Gly 
1               5                   10                  15      


Ala Gly Pro Pro Ser Ala Pro Gly Gly Ser Gly Trp Val Ala Ala Ala 
            20                  25                  30          


Leu Cys Val Val Ile Ala Leu Thr Ala Ala Ala Asn Ser Leu Leu Ile 
        35                  40                  45              


Ala Leu Ile Cys Thr Gln Pro Ala Leu Arg Asn Thr Ser Asn Phe Phe 
    50                  55                  60                  


Leu Val Ser Leu Phe Thr Ser Asp Leu Met Val Gly Leu Val Val Met 
65                  70                  75                  80  


Pro Pro Ala Met Leu Asn Ala Leu Tyr Gly Arg Trp Val Leu Ala Arg 
                85                  90                  95      


Gly Leu Cys Leu Leu Trp Thr Ala Phe Asp Val Met Cys Cys Ser Ala 
            100                 105                 110         


Ser Ile Leu Asn Leu Cys Leu Ile Ser Leu Asp Arg Tyr Leu Leu Ile 
        115                 120                 125             


Leu Ser Pro Leu Arg Tyr Lys Leu Arg Met Thr Pro Leu Arg Ala Leu 
    130                 135                 140                 


Ala Leu Val Leu Gly Ala Trp Ser Leu Ala Ala Leu Ala Ser Phe Leu 
145                 150                 155                 160 


Pro Leu Leu Leu Gly Trp His Glu Leu Gly His Ala Arg Pro Pro Val 
                165                 170                 175     


Pro Gly Gln Cys Arg Leu Leu Ala Ser Leu Pro Phe Val Leu Val Ala 
            180                 185                 190         


Ser Gly Leu Thr Phe Phe Leu Pro Ser Gly Ala Ile Cys Phe Thr Tyr 
        195                 200                 205             


Cys Arg Ile Leu Leu Ala Ala Arg Lys Gln Ala Val Gln Val Ala Ser 
    210                 215                 220                 


Leu Thr Thr Gly Met Ala Ser Gln Ala Ser Glu Thr Leu Gln Val Pro 
225                 230                 235                 240 


Arg Thr Pro Arg Pro Gly Val Glu Ser Ala Asp Ser Arg Arg Leu Ala 
                245                 250                 255     


Thr Lys His Ser Arg Lys Ala Leu Lys Ala Ser Leu Thr Leu Gly Ile 
            260                 265                 270         


Leu Leu Gly Met Phe Phe Val Thr Trp Leu Pro Phe Phe Val Ala Asn 
        275                 280                 285             


Ile Val Gln Ala Val Cys Asp Cys Ile Ser Pro Gly Leu Phe Asp Val 
    290                 295                 300                 


Leu Thr Trp Leu Gly Tyr Cys Asn Ser Thr Met Asn Pro Ile Ile Tyr 
305                 310                 315                 320 


Pro Leu Phe Met Arg Asp Phe Lys Arg Ala Leu Gly Arg Phe Leu Pro 
                325                 330                 335     


Cys Pro Arg Cys Pro Arg Glu Arg Gln Ala Ser Leu Ala Ser Pro Ser 
            340                 345                 350         


Leu Arg Thr Ser His Ser Gly Pro Arg Pro Gly Leu Ser Leu Gln Gln 
        355                 360                 365             


Val Leu Pro Leu Pro Leu Pro Pro Asp Ser Asp Ser Asp Ser Asp Ala 
    370                 375                 380                 


Gly Ser Gly Gly Ser Ser Gly Leu Arg Leu Thr Ala Gln Leu Leu Leu 
385                 390                 395                 400 


Pro Gly Glu Ala Thr Gln Asp Pro Pro Leu Pro Thr Arg Ala Ala Ala 
                405                 410                 415     


Ala Val Asn Phe Phe Asn Ile Asp Pro Ala Glu Pro Glu Leu Arg Pro 
            420                 425                 430         


His Pro Leu Gly Ile Pro Thr Asn 
        435                 440 


<210>  305
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  305

Met Met Asp Val Asn Ser Ser Gly Arg Pro Asp Leu Tyr Gly His Leu 
1               5                   10                  15      


Arg Ser Phe Leu Leu Pro Glu Val Gly Arg Gly Leu Pro Asp Leu Ser 
            20                  25                  30          


Pro Asp Gly Gly Ala Asp Pro Val Ala Gly Ser Trp Ala Pro His Leu 
        35                  40                  45              


Leu Ser Glu Val Thr Ala Ser Pro Ala Pro Thr Trp Asp Ala Pro Pro 
    50                  55                  60                  


Asp Asn Ala Ser Gly Cys Gly Glu Gln Ile Asn Tyr Gly Arg Val Glu 
65                  70                  75                  80  


Lys Val Val Ile Gly Ser Ile Leu Thr Leu Ile Thr Leu Leu Thr Ile 
                85                  90                  95      


Ala Gly Asn Cys Leu Val Val Ile Ser Val Cys Phe Val Lys Lys Leu 
            100                 105                 110         


Arg Gln Pro Ser Asn Tyr Leu Ile Val Ser Leu Ala Leu Ala Asp Leu 
        115                 120                 125             


Ser Val Ala Val Ala Val Met Pro Phe Val Ser Val Thr Asp Leu Ile 
    130                 135                 140                 


Gly Gly Lys Trp Ile Phe Gly His Phe Phe Cys Asn Val Phe Ile Ala 
145                 150                 155                 160 


Met Asp Val Met Cys Cys Thr Ala Ser Ile Met Thr Leu Cys Val Ile 
                165                 170                 175     


Ser Ile Asp Arg Tyr Leu Gly Ile Thr Arg Pro Leu Thr Tyr Pro Val 
            180                 185                 190         


Arg Gln Asn Gly Lys Cys Met Ala Lys Met Ile Leu Ser Val Trp Leu 
        195                 200                 205             


Leu Ser Ala Ser Ile Thr Leu Pro Pro Leu Phe Gly Trp Ala Gln Asn 
    210                 215                 220                 


Val Asn Asp Asp Lys Val Cys Leu Ile Ser Gln Asp Phe Gly Tyr Thr 
225                 230                 235                 240 


Ile Tyr Ser Thr Ala Val Ala Phe Tyr Ile Pro Met Ser Val Met Leu 
                245                 250                 255     


Phe Met Tyr Tyr Gln Ile Tyr Lys Ala Ala Arg Lys Ser Ala Ala Lys 
            260                 265                 270         


His Lys Phe Pro Gly Phe Pro Arg Val Glu Pro Asp Ser Val Ile Ala 
        275                 280                 285             


Leu Asn Gly Ile Val Lys Leu Gln Lys Glu Val Glu Glu Cys Ala Asn 
    290                 295                 300                 


Leu Ser Arg Leu Leu Lys His Glu Arg Lys Asn Ile Ser Ile Phe Lys 
305                 310                 315                 320 


Arg Glu Gln Lys Ala Ala Thr Thr Leu Gly Ile Ile Val Gly Ala Phe 
                325                 330                 335     


Thr Val Cys Trp Leu Pro Phe Phe Leu Leu Ser Thr Ala Arg Pro Phe 
            340                 345                 350         


Ile Cys Gly Thr Ser Cys Ser Cys Ile Pro Leu Trp Val Glu Arg Thr 
        355                 360                 365             


Phe Leu Trp Leu Gly Tyr Ala Asn Ser Leu Ile Asn Pro Phe Ile Tyr 
    370                 375                 380                 


Ala Phe Phe Asn Arg Asp Leu Arg Thr Thr Tyr Arg Ser Leu Leu Gln 
385                 390                 395                 400 


Cys Gln Tyr Arg Asn Ile Asn Arg Lys Leu Ser Ala Ala Gly Met His 
                405                 410                 415     


Glu Ala Leu Lys Leu Ala Glu Arg Pro Glu Arg Pro Glu Phe Val Leu 
            420                 425                 430         


Gln Asn Ala Asp Tyr Cys Arg Lys Lys Gly His Asp Ser 
        435                 440                 445 


<210>  306
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  306

Met Ser Ser Phe Gly Tyr Arg Thr Leu Thr Val Ala Leu Phe Thr Leu 
1               5                   10                  15      


Ile Cys Cys Pro Gly Ser Asp Glu Lys Val Phe Glu Val His Val Arg 
            20                  25                  30          


Pro Lys Lys Leu Ala Val Glu Pro Lys Gly Ser Leu Glu Val Asn Cys 
        35                  40                  45              


Ser Thr Thr Cys Asn Gln Pro Glu Val Gly Gly Leu Glu Thr Ser Leu 
    50                  55                  60                  


Asp Lys Ile Leu Leu Asp Glu Gln Ala Gln Trp Lys His Tyr Leu Val 
65                  70                  75                  80  


Ser Asn Ile Ser His Asp Thr Val Leu Gln Cys His Phe Thr Cys Ser 
                85                  90                  95      


Gly Lys Gln Glu Ser Met Asn Ser Asn Val Ser Val Tyr Gln Pro Pro 
            100                 105                 110         


Arg Gln Val Ile Leu Thr Leu Gln Pro Thr Leu Val Ala Val Gly Lys 
        115                 120                 125             


Ser Phe Thr Ile Glu Cys Arg Val Pro Thr Val Glu Pro Leu Asp Ser 
    130                 135                 140                 


Leu Thr Leu Phe Leu Phe Arg Gly Asn Glu Thr Leu His Tyr Glu Thr 
145                 150                 155                 160 


Phe Gly Lys Ala Ala Pro Ala Pro Gln Glu Ala Thr Ala Thr Phe Asn 
                165                 170                 175     


Ser Thr Ala Asp Arg Glu Asp Gly His Arg Asn Phe Ser Cys Leu Ala 
            180                 185                 190         


Val Leu Asp Leu Met Ser Arg Gly Gly Asn Ile Phe His Lys His Ser 
        195                 200                 205             


Ala Pro Lys Met Leu Glu Ile Tyr Glu Pro Val Ser Asp Ser Gln Met 
    210                 215                 220                 


Val Ile Ile Val Thr Val Val Ser Val Leu Leu Ser Leu Phe Val Thr 
225                 230                 235                 240 


Ser Val Leu Leu Cys Phe Ile Phe Gly Gln His Leu Arg Gln Gln Arg 
                245                 250                 255     


Met Gly Thr Tyr Gly Val Arg Ala Ala Trp Arg Arg Leu Pro Gln Ala 
            260                 265                 270         


Phe Arg Pro 
        275 


<210>  307
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  307

Met Leu Leu Ser Gln Asn Ala Phe Ile Phe Arg Ser Leu Asn Leu Val 
1               5                   10                  15      


Leu Met Val Tyr Ile Ser Leu Val Phe Gly Ile Ser Tyr Asp Ser Pro 
            20                  25                  30          


Asp Tyr Thr Asp Glu Ser Cys Thr Phe Lys Ile Ser Leu Arg Asn Phe 
        35                  40                  45              


Arg Ser Ile Leu Ser Trp Glu Leu Lys Asn His Ser Ile Val Pro Thr 
    50                  55                  60                  


His Tyr Thr Leu Leu Tyr Thr Ile Met Ser Lys Pro Glu Asp Leu Lys 
65                  70                  75                  80  


Val Val Lys Asn Cys Ala Asn Thr Thr Arg Ser Phe Cys Asp Leu Thr 
                85                  90                  95      


Asp Glu Trp Arg Ser Thr His Glu Ala Tyr Val Thr Val Leu Glu Gly 
            100                 105                 110         


Phe Ser Gly Asn Thr Thr Leu Phe Ser Cys Ser His Asn Phe Trp Leu 
        115                 120                 125             


Ala Ile Asp Met Ser Phe Glu Pro Pro Glu Phe Glu Ile Val Gly Phe 
    130                 135                 140                 


Thr Asn His Ile Asn Val Met Val Lys Phe Pro Ser Ile Val Glu Glu 
145                 150                 155                 160 


Glu Leu Gln Phe Asp Leu Ser Leu Val Ile Glu Glu Gln Ser Glu Gly 
                165                 170                 175     


Ile Val Lys Lys His Lys Pro Glu Ile Lys Gly Asn Met Ser Gly Asn 
            180                 185                 190         


Phe Thr Tyr Ile Ile Asp Lys Leu Ile Pro Asn Thr Asn Tyr Cys Val 
        195                 200                 205             


Ser Val Tyr Leu Glu His Ser Asp Glu Gln Ala Val Ile Lys Ser Pro 
    210                 215                 220                 


Leu Lys Cys Thr Leu Leu Pro Pro Gly Gln Glu Ser Glu Ser Ala Glu 
225                 230                 235                 240 


Ser Ala Lys Ile Gly Gly Ile Ile Thr Val Phe Leu Ile Ala Leu Val 
                245                 250                 255     


Leu Thr Ser Thr Ile Val Thr Leu Lys Trp Ile Gly Tyr Ile Cys Leu 
            260                 265                 270         


Arg Asn Ser Leu Pro Lys Val Leu Arg Gln Gly Leu Ala Lys Gly Trp 
        275                 280                 285             


Asn Ala Val Ala Ile His Arg Cys Ser His Asn Ala Leu Gln Ser Glu 
    290                 295                 300                 


Thr Pro Glu Leu Lys Gln Ser Ser Cys Leu Ser Phe Pro Ser Ser Trp 
305                 310                 315                 320 


Asp Tyr Lys Arg Ala Ser Leu Cys Pro Ser Asp 
                325                 330     


<210>  308
<211>  1367
<212>  PRT
<213>  Homo sapiens

<400>  308

Met Lys Ser Gly Ser Gly Gly Gly Ser Pro Thr Ser Leu Trp Gly Leu 
1               5                   10                  15      


Leu Phe Leu Ser Ala Ala Leu Ser Leu Trp Pro Thr Ser Gly Glu Ile 
            20                  25                  30          


Cys Gly Pro Gly Ile Asp Ile Arg Asn Asp Tyr Gln Gln Leu Lys Arg 
        35                  40                  45              


Leu Glu Asn Cys Thr Val Ile Glu Gly Tyr Leu His Ile Leu Leu Ile 
    50                  55                  60                  


Ser Lys Ala Glu Asp Tyr Arg Ser Tyr Arg Phe Pro Lys Leu Thr Val 
65                  70                  75                  80  


Ile Thr Glu Tyr Leu Leu Leu Phe Arg Val Ala Gly Leu Glu Ser Leu 
                85                  90                  95      


Gly Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Trp Lys Leu Phe 
            100                 105                 110         


Tyr Asn Tyr Ala Leu Val Ile Phe Glu Met Thr Asn Leu Lys Asp Ile 
        115                 120                 125             


Gly Leu Tyr Asn Leu Arg Asn Ile Thr Arg Gly Ala Ile Arg Ile Glu 
    130                 135                 140                 


Lys Asn Ala Asp Leu Cys Tyr Leu Ser Thr Val Asp Trp Ser Leu Ile 
145                 150                 155                 160 


Leu Asp Ala Val Ser Asn Asn Tyr Ile Val Gly Asn Lys Pro Pro Lys 
                165                 170                 175     


Glu Cys Gly Asp Leu Cys Pro Gly Thr Met Glu Glu Lys Pro Met Cys 
            180                 185                 190         


Glu Lys Thr Thr Ile Asn Asn Glu Tyr Asn Tyr Arg Cys Trp Thr Thr 
        195                 200                 205             


Asn Arg Cys Gln Lys Met Cys Pro Ser Thr Cys Gly Lys Arg Ala Cys 
    210                 215                 220                 


Thr Glu Asn Asn Glu Cys Cys His Pro Glu Cys Leu Gly Ser Cys Ser 
225                 230                 235                 240 


Ala Pro Asp Asn Asp Thr Ala Cys Val Ala Cys Arg His Tyr Tyr Tyr 
                245                 250                 255     


Ala Gly Val Cys Val Pro Ala Cys Pro Pro Asn Thr Tyr Arg Phe Glu 
            260                 265                 270         


Gly Trp Arg Cys Val Asp Arg Asp Phe Cys Ala Asn Ile Leu Ser Ala 
        275                 280                 285             


Glu Ser Ser Asp Ser Glu Gly Phe Val Ile His Asp Gly Glu Cys Met 
    290                 295                 300                 


Gln Glu Cys Pro Ser Gly Phe Ile Arg Asn Gly Ser Gln Ser Met Tyr 
305                 310                 315                 320 


Cys Ile Pro Cys Glu Gly Pro Cys Pro Lys Val Cys Glu Glu Glu Lys 
                325                 330                 335     


Lys Thr Lys Thr Ile Asp Ser Val Thr Ser Ala Gln Met Leu Gln Gly 
            340                 345                 350         


Cys Thr Ile Phe Lys Gly Asn Leu Leu Ile Asn Ile Arg Arg Gly Asn 
        355                 360                 365             


Asn Ile Ala Ser Glu Leu Glu Asn Phe Met Gly Leu Ile Glu Val Val 
    370                 375                 380                 


Thr Gly Tyr Val Lys Ile Arg His Ser His Ala Leu Val Ser Leu Ser 
385                 390                 395                 400 


Phe Leu Lys Asn Leu Arg Leu Ile Leu Gly Glu Glu Gln Leu Glu Gly 
                405                 410                 415     


Asn Tyr Ser Phe Tyr Val Leu Asp Asn Gln Asn Leu Gln Gln Leu Trp 
            420                 425                 430         


Asp Trp Asp His Arg Asn Leu Thr Ile Lys Ala Gly Lys Met Tyr Phe 
        435                 440                 445             


Ala Phe Asn Pro Lys Leu Cys Val Ser Glu Ile Tyr Arg Met Glu Glu 
    450                 455                 460                 


Val Thr Gly Thr Lys Gly Arg Gln Ser Lys Gly Asp Ile Asn Thr Arg 
465                 470                 475                 480 


Asn Asn Gly Glu Arg Ala Ser Cys Glu Ser Asp Val Leu His Phe Thr 
                485                 490                 495     


Ser Thr Thr Thr Ser Lys Asn Arg Ile Ile Ile Thr Trp His Arg Tyr 
            500                 505                 510         


Arg Pro Pro Asp Tyr Arg Asp Leu Ile Ser Phe Thr Val Tyr Tyr Lys 
        515                 520                 525             


Glu Ala Pro Phe Lys Asn Val Thr Glu Tyr Asp Gly Gln Asp Ala Cys 
    530                 535                 540                 


Gly Ser Asn Ser Trp Asn Met Val Asp Val Asp Leu Pro Pro Asn Lys 
545                 550                 555                 560 


Asp Val Glu Pro Gly Ile Leu Leu His Gly Leu Lys Pro Trp Thr Gln 
                565                 570                 575     


Tyr Ala Val Tyr Val Lys Ala Val Thr Leu Thr Met Val Glu Asn Asp 
            580                 585                 590         


His Ile Arg Gly Ala Lys Ser Glu Ile Leu Tyr Ile Arg Thr Asn Ala 
        595                 600                 605             


Ser Val Pro Ser Ile Pro Leu Asp Val Leu Ser Ala Ser Asn Ser Ser 
    610                 615                 620                 


Ser Gln Leu Ile Val Lys Trp Asn Pro Pro Ser Leu Pro Asn Gly Asn 
625                 630                 635                 640 


Leu Ser Tyr Tyr Ile Val Arg Trp Gln Arg Gln Pro Gln Asp Gly Tyr 
                645                 650                 655     


Leu Tyr Arg His Asn Tyr Cys Ser Lys Asp Lys Ile Pro Ile Arg Lys 
            660                 665                 670         


Tyr Ala Asp Gly Thr Ile Asp Ile Glu Glu Val Thr Glu Asn Pro Lys 
        675                 680                 685             


Thr Glu Val Cys Gly Gly Glu Lys Gly Pro Cys Cys Ala Cys Pro Lys 
    690                 695                 700                 


Thr Glu Ala Glu Lys Gln Ala Glu Lys Glu Glu Ala Glu Tyr Arg Lys 
705                 710                 715                 720 


Val Phe Glu Asn Phe Leu His Asn Ser Ile Phe Val Pro Arg Pro Glu 
                725                 730                 735     


Arg Lys Arg Arg Asp Val Met Gln Val Ala Asn Thr Thr Met Ser Ser 
            740                 745                 750         


Arg Ser Arg Asn Thr Thr Ala Ala Asp Thr Tyr Asn Ile Thr Asp Pro 
        755                 760                 765             


Glu Glu Leu Glu Thr Glu Tyr Pro Phe Phe Glu Ser Arg Val Asp Asn 
    770                 775                 780                 


Lys Glu Arg Thr Val Ile Ser Asn Leu Arg Pro Phe Thr Leu Tyr Arg 
785                 790                 795                 800 


Ile Asp Ile His Ser Cys Asn His Glu Ala Glu Lys Leu Gly Cys Ser 
                805                 810                 815     


Ala Ser Asn Phe Val Phe Ala Arg Thr Met Pro Ala Glu Gly Ala Asp 
            820                 825                 830         


Asp Ile Pro Gly Pro Val Thr Trp Glu Pro Arg Pro Glu Asn Ser Ile 
        835                 840                 845             


Phe Leu Lys Trp Pro Glu Pro Glu Asn Pro Asn Gly Leu Ile Leu Met 
    850                 855                 860                 


Tyr Glu Ile Lys Tyr Gly Ser Gln Val Glu Asp Gln Arg Glu Cys Val 
865                 870                 875                 880 


Ser Arg Gln Glu Tyr Arg Lys Tyr Gly Gly Ala Lys Leu Asn Arg Leu 
                885                 890                 895     


Asn Pro Gly Asn Tyr Thr Ala Arg Ile Gln Ala Thr Ser Leu Ser Gly 
            900                 905                 910         


Asn Gly Ser Trp Thr Asp Pro Val Phe Phe Tyr Val Gln Ala Lys Thr 
        915                 920                 925             


Gly Tyr Glu Asn Phe Ile His Leu Ile Ile Ala Leu Pro Val Ala Val 
    930                 935                 940                 


Leu Leu Ile Val Gly Gly Leu Val Ile Met Leu Tyr Val Phe His Arg 
945                 950                 955                 960 


Lys Arg Asn Asn Ser Arg Leu Gly Asn Gly Val Leu Tyr Ala Ser Val 
                965                 970                 975     


Asn Pro Glu Tyr Phe Ser Ala Ala Asp Val Tyr Val Pro Asp Glu Trp 
            980                 985                 990         


Glu Val Ala Arg Glu Lys Ile Thr  Met Ser Arg Glu Leu  Gly Gln Gly 
        995                 1000                 1005             


Ser Phe  Gly Met Val Tyr Glu  Gly Val Ala Lys Gly  Val Val Lys 
    1010                 1015                 1020             


Asp Glu  Pro Glu Thr Arg Val  Ala Ile Lys Thr Val  Asn Glu Ala 
    1025                 1030                 1035             


Ala Ser  Met Arg Glu Arg Ile  Glu Phe Leu Asn Glu  Ala Ser Val 
    1040                 1045                 1050             


Met Lys  Glu Phe Asn Cys His  His Val Val Arg Leu  Leu Gly Val 
    1055                 1060                 1065             


Val Ser  Gln Gly Gln Pro Thr  Leu Val Ile Met Glu  Leu Met Thr 
    1070                 1075                 1080             


Arg Gly  Asp Leu Lys Ser Tyr  Leu Arg Ser Leu Arg  Pro Glu Met 
    1085                 1090                 1095             


Glu Asn  Asn Pro Val Leu Ala  Pro Pro Ser Leu Ser  Lys Met Ile 
    1100                 1105                 1110             


Gln Met  Ala Gly Glu Ile Ala  Asp Gly Met Ala Tyr  Leu Asn Ala 
    1115                 1120                 1125             


Asn Lys  Phe Val His Arg Asp  Leu Ala Ala Arg Asn  Cys Met Val 
    1130                 1135                 1140             


Ala Glu  Asp Phe Thr Val Lys  Ile Gly Asp Phe Gly  Met Thr Arg 
    1145                 1150                 1155             


Asp Ile  Tyr Glu Thr Asp Tyr  Tyr Arg Lys Gly Gly  Lys Gly Leu 
    1160                 1165                 1170             


Leu Pro  Val Arg Trp Met Ser  Pro Glu Ser Leu Lys  Asp Gly Val 
    1175                 1180                 1185             


Phe Thr  Thr Tyr Ser Asp Val  Trp Ser Phe Gly Val  Val Leu Trp 
    1190                 1195                 1200             


Glu Ile  Ala Thr Leu Ala Glu  Gln Pro Tyr Gln Gly  Leu Ser Asn 
    1205                 1210                 1215             


Glu Gln  Val Leu Arg Phe Val  Met Glu Gly Gly Leu  Leu Asp Lys 
    1220                 1225                 1230             


Pro Asp  Asn Cys Pro Asp Met  Leu Phe Glu Leu Met  Arg Met Cys 
    1235                 1240                 1245             


Trp Gln  Tyr Asn Pro Lys Met  Arg Pro Ser Phe Leu  Glu Ile Ile 
    1250                 1255                 1260             


Ser Ser  Ile Lys Glu Glu Met  Glu Pro Gly Phe Arg  Glu Val Ser 
    1265                 1270                 1275             


Phe Tyr  Tyr Ser Glu Glu Asn  Lys Leu Pro Glu Pro  Glu Glu Leu 
    1280                 1285                 1290             


Asp Leu  Glu Pro Glu Asn Met  Glu Ser Val Pro Leu  Asp Pro Ser 
    1295                 1300                 1305             


Ala Ser  Ser Ser Ser Leu Pro  Leu Pro Asp Arg His  Ser Gly His 
    1310                 1315                 1320             


Lys Ala  Glu Asn Gly Pro Gly  Pro Gly Val Leu Val  Leu Arg Ala 
    1325                 1330                 1335             


Ser Phe  Asp Glu Arg Gln Pro  Tyr Ala His Met Asn  Gly Gly Arg 
    1340                 1345                 1350             


Lys Asn  Glu Arg Ala Leu Pro  Leu Pro Gln Ser Ser  Thr Cys 
    1355                 1360                 1365         


<210>  309
<211>  2491
<212>  PRT
<213>  Homo sapiens

<400>  309

Met Gly Ala Ala Ala Gly Arg Ser Pro His Leu Gly Pro Ala Pro Ala 
1               5                   10                  15      


Arg Arg Pro Gln Arg Ser Leu Leu Leu Leu Gln Leu Leu Leu Leu Val 
            20                  25                  30          


Ala Ala Pro Gly Ser Thr Gln Ala Gln Ala Ala Pro Phe Pro Glu Leu 
        35                  40                  45              


Cys Ser Tyr Thr Trp Glu Ala Val Asp Thr Lys Asn Asn Val Leu Tyr 
    50                  55                  60                  


Lys Ile Asn Ile Cys Gly Ser Val Asp Ile Val Gln Cys Gly Pro Ser 
65                  70                  75                  80  


Ser Ala Val Cys Met His Asp Leu Lys Thr Arg Thr Tyr His Ser Val 
                85                  90                  95      


Gly Asp Ser Val Leu Arg Ser Ala Thr Arg Ser Leu Leu Glu Phe Asn 
            100                 105                 110         


Thr Thr Val Ser Cys Asp Gln Gln Gly Thr Asn His Arg Val Gln Ser 
        115                 120                 125             


Ser Ile Ala Phe Leu Cys Gly Lys Thr Leu Gly Thr Pro Glu Phe Val 
    130                 135                 140                 


Thr Ala Thr Glu Cys Val His Tyr Phe Glu Trp Arg Thr Thr Ala Ala 
145                 150                 155                 160 


Cys Lys Lys Asp Ile Phe Lys Ala Asn Lys Glu Val Pro Cys Tyr Val 
                165                 170                 175     


Phe Asp Glu Glu Leu Arg Lys His Asp Leu Asn Pro Leu Ile Lys Leu 
            180                 185                 190         


Ser Gly Ala Tyr Leu Val Asp Asp Ser Asp Pro Asp Thr Ser Leu Phe 
        195                 200                 205             


Ile Asn Val Cys Arg Asp Ile Asp Thr Leu Arg Asp Pro Gly Ser Gln 
    210                 215                 220                 


Leu Arg Ala Cys Pro Pro Gly Thr Ala Ala Cys Leu Val Arg Gly His 
225                 230                 235                 240 


Gln Ala Phe Asp Val Gly Gln Pro Arg Asp Gly Leu Lys Leu Val Arg 
                245                 250                 255     


Lys Asp Arg Leu Val Leu Ser Tyr Val Arg Glu Glu Ala Gly Lys Leu 
            260                 265                 270         


Asp Phe Cys Asp Gly His Ser Pro Ala Val Thr Ile Thr Phe Val Cys 
        275                 280                 285             


Pro Ser Glu Arg Arg Glu Gly Thr Ile Pro Lys Leu Thr Ala Lys Ser 
    290                 295                 300                 


Asn Cys Arg Tyr Glu Ile Glu Trp Ile Thr Glu Tyr Ala Cys His Arg 
305                 310                 315                 320 


Asp Tyr Leu Glu Ser Lys Thr Cys Ser Leu Ser Gly Glu Gln Gln Asp 
                325                 330                 335     


Val Ser Ile Asp Leu Thr Pro Leu Ala Gln Ser Gly Gly Ser Ser Tyr 
            340                 345                 350         


Ile Ser Asp Gly Lys Glu Tyr Leu Phe Tyr Leu Asn Val Cys Gly Glu 
        355                 360                 365             


Thr Glu Ile Gln Phe Cys Asn Lys Lys Gln Ala Ala Val Cys Gln Val 
    370                 375                 380                 


Lys Lys Ser Asp Thr Ser Gln Val Lys Ala Ala Gly Arg Tyr His Asn 
385                 390                 395                 400 


Gln Thr Leu Arg Tyr Ser Asp Gly Asp Leu Thr Leu Ile Tyr Phe Gly 
                405                 410                 415     


Gly Asp Glu Cys Ser Ser Gly Phe Gln Arg Met Ser Val Ile Asn Phe 
            420                 425                 430         


Glu Cys Asn Lys Thr Ala Gly Asn Asp Gly Lys Gly Thr Pro Val Phe 
        435                 440                 445             


Thr Gly Glu Val Asp Cys Thr Tyr Phe Phe Thr Trp Asp Thr Glu Tyr 
    450                 455                 460                 


Ala Cys Val Lys Glu Lys Glu Asp Leu Leu Cys Gly Ala Thr Asp Gly 
465                 470                 475                 480 


Lys Lys Arg Tyr Asp Leu Ser Ala Leu Val Arg His Ala Glu Pro Glu 
                485                 490                 495     


Gln Asn Trp Glu Ala Val Asp Gly Ser Gln Thr Glu Thr Glu Lys Lys 
            500                 505                 510         


His Phe Phe Ile Asn Ile Cys His Arg Val Leu Gln Glu Gly Lys Ala 
        515                 520                 525             


Arg Gly Cys Pro Glu Asp Ala Ala Val Cys Ala Val Asp Lys Asn Gly 
    530                 535                 540                 


Ser Lys Asn Leu Gly Lys Phe Ile Ser Ser Pro Met Lys Glu Lys Gly 
545                 550                 555                 560 


Asn Ile Gln Leu Ser Tyr Ser Asp Gly Asp Asp Cys Gly His Gly Lys 
                565                 570                 575     


Lys Ile Lys Thr Asn Ile Thr Leu Val Cys Lys Pro Gly Asp Leu Glu 
            580                 585                 590         


Ser Ala Pro Val Leu Arg Thr Ser Gly Glu Gly Gly Cys Phe Tyr Glu 
        595                 600                 605             


Phe Glu Trp His Thr Ala Ala Ala Cys Val Leu Ser Lys Thr Glu Gly 
    610                 615                 620                 


Glu Asn Cys Thr Val Phe Asp Ser Gln Ala Gly Phe Ser Phe Asp Leu 
625                 630                 635                 640 


Ser Pro Leu Thr Lys Lys Asn Gly Ala Tyr Lys Val Glu Thr Lys Lys 
                645                 650                 655     


Tyr Asp Phe Tyr Ile Asn Val Cys Gly Pro Val Ser Val Ser Pro Cys 
            660                 665                 670         


Gln Pro Asp Ser Gly Ala Cys Gln Val Ala Lys Ser Asp Glu Lys Thr 
        675                 680                 685             


Trp Asn Leu Gly Leu Ser Asn Ala Lys Leu Ser Tyr Tyr Asp Gly Met 
    690                 695                 700                 


Ile Gln Leu Asn Tyr Arg Gly Gly Thr Pro Tyr Asn Asn Glu Arg His 
705                 710                 715                 720 


Thr Pro Arg Ala Thr Leu Ile Thr Phe Leu Cys Asp Arg Asp Ala Gly 
                725                 730                 735     


Val Gly Phe Pro Glu Tyr Gln Glu Glu Asp Asn Ser Thr Tyr Asn Phe 
            740                 745                 750         


Arg Trp Tyr Thr Ser Tyr Ala Cys Pro Glu Glu Pro Leu Glu Cys Val 
        755                 760                 765             


Val Thr Asp Pro Ser Thr Leu Glu Gln Tyr Asp Leu Ser Ser Leu Ala 
    770                 775                 780                 


Lys Ser Glu Gly Gly Leu Gly Gly Asn Trp Tyr Ala Met Asp Asn Ser 
785                 790                 795                 800 


Gly Glu His Val Thr Trp Arg Lys Tyr Tyr Ile Asn Val Cys Arg Pro 
                805                 810                 815     


Leu Asn Pro Val Pro Gly Cys Asn Arg Tyr Ala Ser Ala Cys Gln Met 
            820                 825                 830         


Lys Tyr Glu Lys Asp Gln Gly Ser Phe Thr Glu Val Val Ser Ile Ser 
        835                 840                 845             


Asn Leu Gly Met Ala Lys Thr Gly Pro Val Val Glu Asp Ser Gly Ser 
    850                 855                 860                 


Leu Leu Leu Glu Tyr Val Asn Gly Ser Ala Cys Thr Thr Ser Asp Gly 
865                 870                 875                 880 


Arg Gln Thr Thr Tyr Thr Thr Arg Ile His Leu Val Cys Ser Arg Gly 
                885                 890                 895     


Arg Leu Asn Ser His Pro Ile Phe Ser Leu Asn Trp Glu Cys Val Val 
            900                 905                 910         


Ser Phe Leu Trp Asn Thr Glu Ala Ala Cys Pro Ile Gln Thr Thr Thr 
        915                 920                 925             


Asp Thr Asp Gln Ala Cys Ser Ile Arg Asp Pro Asn Ser Gly Phe Val 
    930                 935                 940                 


Phe Asn Leu Asn Pro Leu Asn Ser Ser Gln Gly Tyr Asn Val Ser Gly 
945                 950                 955                 960 


Ile Gly Lys Ile Phe Met Phe Asn Val Cys Gly Thr Met Pro Val Cys 
                965                 970                 975     


Gly Thr Ile Leu Gly Lys Pro Ala Ser Gly Cys Glu Ala Glu Thr Gln 
            980                 985                 990         


Thr Glu Glu Leu Lys Asn Trp Lys  Pro Ala Arg Pro Val  Gly Ile Glu 
        995                 1000                 1005             


Lys Ser  Leu Gln Leu Ser Thr  Glu Gly Phe Ile Thr  Leu Thr Tyr 
    1010                 1015                 1020             


Lys Gly  Pro Leu Ser Ala Lys  Gly Thr Ala Asp Ala  Phe Ile Val 
    1025                 1030                 1035             


Arg Phe  Val Cys Asn Asp Asp  Val Tyr Ser Gly Pro  Leu Lys Phe 
    1040                 1045                 1050             


Leu His  Gln Asp Ile Asp Ser  Gly Gln Gly Ile Arg  Asn Thr Tyr 
    1055                 1060                 1065             


Phe Glu  Phe Glu Thr Ala Leu  Ala Cys Val Pro Ser  Pro Val Asp 
    1070                 1075                 1080             


Cys Gln  Val Thr Asp Leu Ala  Gly Asn Glu Tyr Asp  Leu Thr Gly 
    1085                 1090                 1095             


Leu Ser  Thr Val Arg Lys Pro  Trp Thr Ala Val Asp  Thr Ser Val 
    1100                 1105                 1110             


Asp Gly  Arg Lys Arg Thr Phe  Tyr Leu Ser Val Cys  Asn Pro Leu 
    1115                 1120                 1125             


Pro Tyr  Ile Pro Gly Cys Gln  Gly Ser Ala Val Gly  Ser Cys Leu 
    1130                 1135                 1140             


Val Ser  Glu Gly Asn Ser Trp  Asn Leu Gly Val Val  Gln Met Ser 
    1145                 1150                 1155             


Pro Gln  Ala Ala Ala Asn Gly  Ser Leu Ser Ile Met  Tyr Val Asn 
    1160                 1165                 1170             


Gly Asp  Lys Cys Gly Asn Gln  Arg Phe Ser Thr Arg  Ile Thr Phe 
    1175                 1180                 1185             


Glu Cys  Ala Gln Ile Ser Gly  Ser Pro Ala Phe Gln  Leu Gln Asp 
    1190                 1195                 1200             


Gly Cys  Glu Tyr Val Phe Ile  Trp Arg Thr Val Glu  Ala Cys Pro 
    1205                 1210                 1215             


Val Val  Arg Val Glu Gly Asp  Asn Cys Glu Val Lys  Asp Pro Arg 
    1220                 1225                 1230             


His Gly  Asn Leu Tyr Asp Leu  Lys Pro Leu Gly Leu  Asn Asp Thr 
    1235                 1240                 1245             


Ile Val  Ser Ala Gly Glu Tyr  Thr Tyr Tyr Phe Arg  Val Cys Gly 
    1250                 1255                 1260             


Lys Leu  Ser Ser Asp Val Cys  Pro Thr Ser Asp Lys  Ser Lys Val 
    1265                 1270                 1275             


Val Ser  Ser Cys Gln Glu Lys  Arg Glu Pro Gln Gly  Phe His Lys 
    1280                 1285                 1290             


Val Ala  Gly Leu Leu Thr Gln  Lys Leu Thr Tyr Glu  Asn Gly Leu 
    1295                 1300                 1305             


Leu Lys  Met Asn Phe Thr Gly  Gly Asp Thr Cys His  Lys Val Tyr 
    1310                 1315                 1320             


Gln Arg  Ser Thr Ala Ile Phe  Phe Tyr Cys Asp Arg  Gly Thr Gln 
    1325                 1330                 1335             


Arg Pro  Val Phe Leu Lys Glu  Thr Ser Asp Cys Ser  Tyr Leu Phe 
    1340                 1345                 1350             


Glu Trp  Arg Thr Gln Tyr Ala  Cys Pro Pro Phe Asp  Leu Thr Glu 
    1355                 1360                 1365             


Cys Ser  Phe Lys Asp Gly Ala  Gly Asn Ser Phe Asp  Leu Ser Ser 
    1370                 1375                 1380             


Leu Ser  Arg Tyr Ser Asp Asn  Trp Glu Ala Ile Thr  Gly Thr Gly 
    1385                 1390                 1395             


Asp Pro  Glu His Tyr Leu Ile  Asn Val Cys Lys Ser  Leu Ala Pro 
    1400                 1405                 1410             


Gln Ala  Gly Thr Glu Pro Cys  Pro Pro Glu Ala Ala  Ala Cys Leu 
    1415                 1420                 1425             


Leu Gly  Gly Ser Lys Pro Val  Asn Leu Gly Arg Val  Arg Asp Gly 
    1430                 1435                 1440             


Pro Gln  Trp Arg Asp Gly Ile  Ile Val Leu Lys Tyr  Val Asp Gly 
    1445                 1450                 1455             


Asp Leu  Cys Pro Asp Gly Ile  Arg Lys Lys Ser Thr  Thr Ile Arg 
    1460                 1465                 1470             


Phe Thr  Cys Ser Glu Ser Gln  Val Asn Ser Arg Pro  Met Phe Ile 
    1475                 1480                 1485             


Ser Ala  Val Glu Asp Cys Glu  Tyr Thr Phe Ala Trp  Pro Thr Ala 
    1490                 1495                 1500             


Thr Ala  Cys Pro Met Lys Ser  Asn Glu His Asp Asp  Cys Gln Val 
    1505                 1510                 1515             


Thr Asn  Pro Ser Thr Gly His  Leu Phe Asp Leu Ser  Ser Leu Ser 
    1520                 1525                 1530             


Gly Arg  Ala Gly Phe Thr Ala  Ala Tyr Ser Glu Lys  Gly Leu Val 
    1535                 1540                 1545             


Tyr Met  Ser Ile Cys Gly Glu  Asn Glu Asn Cys Pro  Pro Gly Val 
    1550                 1555                 1560             


Gly Ala  Cys Phe Gly Gln Thr  Arg Ile Ser Val Gly  Lys Ala Asn 
    1565                 1570                 1575             


Lys Arg  Leu Arg Tyr Val Asp  Gln Val Leu Gln Leu  Val Tyr Lys 
    1580                 1585                 1590             


Asp Gly  Ser Pro Cys Pro Ser  Lys Ser Gly Leu Ser  Tyr Lys Ser 
    1595                 1600                 1605             


Val Ile  Ser Phe Val Cys Arg  Pro Glu Ala Gly Pro  Thr Asn Arg 
    1610                 1615                 1620             


Pro Met  Leu Ile Ser Leu Asp  Lys Gln Thr Cys Thr  Leu Phe Phe 
    1625                 1630                 1635             


Ser Trp  His Thr Pro Leu Ala  Cys Glu Gln Ala Thr  Glu Cys Ser 
    1640                 1645                 1650             


Val Arg  Asn Gly Ser Ser Ile  Val Asp Leu Ser Pro  Leu Ile His 
    1655                 1660                 1665             


Arg Thr  Gly Gly Tyr Glu Ala  Tyr Asp Glu Ser Glu  Asp Asp Ala 
    1670                 1675                 1680             


Ser Asp  Thr Asn Pro Asp Phe  Tyr Ile Asn Ile Cys  Gln Pro Leu 
    1685                 1690                 1695             


Asn Pro  Met His Gly Val Pro  Cys Pro Ala Gly Ala  Ala Val Cys 
    1700                 1705                 1710             


Lys Val  Pro Ile Asp Gly Pro  Pro Ile Asp Ile Gly  Arg Val Ala 
    1715                 1720                 1725             


Gly Pro  Pro Ile Leu Asn Pro  Ile Ala Asn Glu Ile  Tyr Leu Asn 
    1730                 1735                 1740             


Phe Glu  Ser Ser Thr Pro Cys  Leu Ala Asp Lys His  Phe Asn Tyr 
    1745                 1750                 1755             


Thr Ser  Leu Ile Ala Phe His  Cys Lys Arg Gly Val  Ser Met Gly 
    1760                 1765                 1770             


Thr Pro  Lys Leu Leu Arg Thr  Ser Glu Cys Asp Phe  Val Phe Glu 
    1775                 1780                 1785             


Trp Glu  Thr Pro Val Val Cys  Pro Asp Glu Val Arg  Met Asp Gly 
    1790                 1795                 1800             


Cys Thr  Leu Thr Asp Glu Gln  Leu Leu Tyr Ser Phe  Asn Leu Ser 
    1805                 1810                 1815             


Ser Leu  Ser Thr Ser Thr Phe  Lys Val Thr Arg Asp  Ser Arg Thr 
    1820                 1825                 1830             


Tyr Ser  Val Gly Val Cys Thr  Phe Ala Val Gly Pro  Glu Gln Gly 
    1835                 1840                 1845             


Gly Cys  Lys Asp Gly Gly Val  Cys Leu Leu Ser Gly  Thr Lys Gly 
    1850                 1855                 1860             


Ala Ser  Phe Gly Arg Leu Gln  Ser Met Lys Leu Asp  Tyr Arg His 
    1865                 1870                 1875             


Gln Asp  Glu Ala Val Val Leu  Ser Tyr Val Asn Gly  Asp Arg Cys 
    1880                 1885                 1890             


Pro Pro  Glu Thr Asp Asp Gly  Val Pro Cys Val Phe  Pro Phe Ile 
    1895                 1900                 1905             


Phe Asn  Gly Lys Ser Tyr Glu  Glu Cys Ile Ile Glu  Ser Arg Ala 
    1910                 1915                 1920             


Lys Leu  Trp Cys Ser Thr Thr  Ala Asp Tyr Asp Arg  Asp His Glu 
    1925                 1930                 1935             


Trp Gly  Phe Cys Arg His Ser  Asn Ser Tyr Arg Thr  Ser Ser Ile 
    1940                 1945                 1950             


Ile Phe  Lys Cys Asp Glu Asp  Glu Asp Ile Gly Arg  Pro Gln Val 
    1955                 1960                 1965             


Phe Ser  Glu Val Arg Gly Cys  Asp Val Thr Phe Glu  Trp Lys Thr 
    1970                 1975                 1980             


Lys Val  Val Cys Pro Pro Lys  Lys Leu Glu Cys Lys  Phe Val Gln 
    1985                 1990                 1995             


Lys His  Lys Thr Tyr Asp Leu  Arg Leu Leu Ser Ser  Leu Thr Gly 
    2000                 2005                 2010             


Ser Trp  Ser Leu Val His Asn  Gly Val Ser Tyr Tyr  Ile Asn Leu 
    2015                 2020                 2025             


Cys Gln  Lys Ile Tyr Lys Gly  Pro Leu Gly Cys Ser  Glu Arg Ala 
    2030                 2035                 2040             


Ser Ile  Cys Arg Arg Thr Thr  Thr Gly Asp Val Gln  Val Leu Gly 
    2045                 2050                 2055             


Leu Val  His Thr Gln Lys Leu  Gly Val Ile Gly Asp  Lys Val Val 
    2060                 2065                 2070             


Val Thr  Tyr Ser Lys Gly Tyr  Pro Cys Gly Gly Asn  Lys Thr Ala 
    2075                 2080                 2085             


Ser Ser  Val Ile Glu Leu Thr  Cys Thr Lys Thr Val  Gly Arg Pro 
    2090                 2095                 2100             


Ala Phe  Lys Arg Phe Asp Ile  Asp Ser Cys Thr Tyr  Tyr Phe Ser 
    2105                 2110                 2115             


Trp Asp  Ser Arg Ala Ala Cys  Ala Val Lys Pro Gln  Glu Val Gln 
    2120                 2125                 2130             


Met Val  Asn Gly Thr Ile Thr  Asn Pro Ile Asn Gly  Lys Ser Phe 
    2135                 2140                 2145             


Ser Leu  Gly Asp Ile Tyr Phe  Lys Leu Phe Arg Ala  Ser Gly Asp 
    2150                 2155                 2160             


Met Arg  Thr Asn Gly Asp Asn  Tyr Leu Tyr Glu Ile  Gln Leu Ser 
    2165                 2170                 2175             


Ser Ile  Thr Ser Ser Arg Asn  Pro Ala Cys Ser Gly  Ala Asn Ile 
    2180                 2185                 2190             


Cys Gln  Val Lys Pro Asn Asp  Gln His Phe Ser Arg  Lys Val Gly 
    2195                 2200                 2205             


Thr Ser  Asp Lys Thr Lys Tyr  Tyr Leu Gln Asp Gly  Asp Leu Asp 
    2210                 2215                 2220             


Val Val  Phe Ala Ser Ser Ser  Lys Cys Gly Lys Asp  Lys Thr Lys 
    2225                 2230                 2235             


Ser Val  Ser Ser Thr Ile Phe  Phe His Cys Asp Pro  Leu Val Glu 
    2240                 2245                 2250             


Asp Gly  Ile Pro Glu Phe Ser  His Glu Thr Ala Asp  Cys Gln Tyr 
    2255                 2260                 2265             


Leu Phe  Ser Trp Tyr Thr Ser  Ala Val Cys Pro Leu  Gly Val Gly 
    2270                 2275                 2280             


Phe Asp  Ser Glu Asn Pro Gly  Asp Asp Gly Gln Met  His Lys Gly 
    2285                 2290                 2295             


Leu Ser  Glu Arg Ser Gln Ala  Val Gly Ala Val Leu  Ser Leu Leu 
    2300                 2305                 2310             


Leu Val  Ala Leu Thr Cys Cys  Leu Leu Ala Leu Leu  Leu Tyr Lys 
    2315                 2320                 2325             


Lys Glu  Arg Arg Glu Thr Val  Ile Ser Lys Leu Thr  Thr Cys Cys 
    2330                 2335                 2340             


Arg Arg  Ser Ser Asn Val Ser  Tyr Lys Tyr Ser Lys  Val Asn Lys 
    2345                 2350                 2355             


Glu Glu  Glu Thr Asp Glu Asn  Glu Thr Glu Trp Leu  Met Glu Glu 
    2360                 2365                 2370             


Ile Gln  Leu Pro Pro Pro Arg  Gln Gly Lys Glu Gly  Gln Glu Asn 
    2375                 2380                 2385             


Gly His  Ile Thr Thr Lys Ser  Val Lys Ala Leu Ser  Ser Leu His 
    2390                 2395                 2400             


Gly Asp  Asp Gln Asp Ser Glu  Asp Glu Val Leu Thr  Ile Pro Glu 
    2405                 2410                 2415             


Val Lys  Val His Ser Gly Arg  Gly Ala Gly Ala Glu  Ser Ser His 
    2420                 2425                 2430             


Pro Val  Arg Asn Ala Gln Ser  Asn Ala Leu Gln Glu  Arg Glu Asp 
    2435                 2440                 2445             


Asp Arg  Val Gly Leu Val Arg  Gly Glu Lys Ala Arg  Lys Gly Lys 
    2450                 2455                 2460             


Ser Ser  Ser Ala Gln Gln Lys  Thr Val Ser Ser Thr  Lys Leu Val 
    2465                 2470                 2475             


Ser Phe  His Asp Asp Ser Asp  Glu Asp Leu Leu His  Ile 
    2480                 2485                 2490     


<210>  310
<211>  569
<212>  PRT
<213>  Homo sapiens

<400>  310

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
            180                 185                 190         


Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
        195                 200                 205             


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
    210                 215                 220                 


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
225                 230                 235                 240 


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
                245                 250                 255     


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
            260                 265                 270         


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
        275                 280                 285             


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
    290                 295                 300                 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
305                 310                 315                 320 


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
                325                 330                 335     


His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
            340                 345                 350         


Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Ala Ser Asp Gly Lys Thr 
    370                 375                 380                 


Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Val Gly Glu Gly Ser Thr 
385                 390                 395                 400 


Ser Asp Cys Asp Ile Phe Val Phe Lys Val Leu Pro Glu Val Leu Glu 
                405                 410                 415     


Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val 
            420                 425                 430         


Gly Glu Asp Ile Val Glu Val Ile Asn Glu Asn Val Lys Lys Ser Arg 
        435                 440                 445             


Arg Leu Ile Ile Ile Leu Val Arg Glu Thr Ser Gly Phe Ser Trp Leu 
    450                 455                 460                 


Gly Gly Ser Ser Glu Glu Gln Ile Ala Met Tyr Asn Ala Leu Val Gln 
465                 470                 475                 480 


Asp Gly Ile Lys Val Val Leu Leu Glu Leu Glu Lys Ile Gln Asp Tyr 
                485                 490                 495     


Glu Lys Met Pro Glu Ser Ile Lys Phe Ile Lys Gln Lys His Gly Ala 
            500                 505                 510         


Ile Arg Trp Ser Gly Asp Phe Thr Gln Gly Pro Gln Ser Ala Lys Thr 
        515                 520                 525             


Arg Phe Trp Lys Asn Val Arg Tyr His Met Pro Val Gln Arg Arg Ser 
    530                 535                 540                 


Pro Ser Ser Lys His Gln Leu Leu Ser Pro Ala Thr Lys Glu Lys Leu 
545                 550                 555                 560 


Gln Arg Glu Ala His Val Pro Leu Gly 
                565                 


<210>  311
<211>  1032
<212>  PRT
<213>  Homo sapiens

<400>  311

Met Ala Trp Glu Ala Arg Arg Glu Pro Gly Pro Arg Arg Ala Ala Val 
1               5                   10                  15      


Arg Glu Thr Val Met Leu Leu Leu Cys Leu Gly Val Pro Thr Gly Arg 
            20                  25                  30          


Pro Tyr Asn Val Asp Thr Glu Ser Ala Leu Leu Tyr Gln Gly Pro His 
        35                  40                  45              


Asn Thr Leu Phe Gly Tyr Ser Val Val Leu His Ser His Gly Ala Asn 
    50                  55                  60                  


Arg Trp Leu Leu Val Gly Ala Pro Thr Ala Asn Trp Leu Ala Asn Ala 
65                  70                  75                  80  


Ser Val Ile Asn Pro Gly Ala Ile Tyr Arg Cys Arg Ile Gly Lys Asn 
                85                  90                  95      


Pro Gly Gln Thr Cys Glu Gln Leu Gln Leu Gly Ser Pro Asn Gly Glu 
            100                 105                 110         


Pro Cys Gly Lys Thr Cys Leu Glu Glu Arg Asp Asn Gln Trp Leu Gly 
        115                 120                 125             


Val Thr Leu Ser Arg Gln Pro Gly Glu Asn Gly Ser Ile Val Thr Cys 
    130                 135                 140                 


Gly His Arg Trp Lys Asn Ile Phe Tyr Ile Lys Asn Glu Asn Lys Leu 
145                 150                 155                 160 


Pro Thr Gly Gly Cys Tyr Gly Val Pro Pro Asp Leu Arg Thr Glu Leu 
                165                 170                 175     


Ser Lys Arg Ile Ala Pro Cys Tyr Gln Asp Tyr Val Lys Lys Phe Gly 
            180                 185                 190         


Glu Asn Phe Ala Ser Cys Gln Ala Gly Ile Ser Ser Phe Tyr Thr Lys 
        195                 200                 205             


Asp Leu Ile Val Met Gly Ala Pro Gly Ser Ser Tyr Trp Thr Gly Ser 
    210                 215                 220                 


Leu Phe Val Tyr Asn Ile Thr Thr Asn Lys Tyr Lys Ala Phe Leu Asp 
225                 230                 235                 240 


Lys Gln Asn Gln Val Lys Phe Gly Ser Tyr Leu Gly Tyr Ser Val Gly 
                245                 250                 255     


Ala Gly His Phe Arg Ser Gln His Thr Thr Glu Val Val Gly Gly Ala 
            260                 265                 270         


Pro Gln His Glu Gln Ile Gly Lys Ala Tyr Ile Phe Ser Ile Asp Glu 
        275                 280                 285             


Lys Glu Leu Asn Ile Leu His Glu Met Lys Gly Lys Lys Leu Gly Ser 
    290                 295                 300                 


Tyr Phe Gly Ala Ser Val Cys Ala Val Asp Leu Asn Ala Asp Gly Phe 
305                 310                 315                 320 


Ser Asp Leu Leu Val Gly Ala Pro Met Gln Ser Thr Ile Arg Glu Glu 
                325                 330                 335     


Gly Arg Val Phe Val Tyr Ile Asn Ser Gly Ser Gly Ala Val Met Asn 
            340                 345                 350         


Ala Met Glu Thr Asn Leu Val Gly Ser Asp Lys Tyr Ala Ala Arg Phe 
        355                 360                 365             


Gly Glu Ser Ile Val Asn Leu Gly Asp Ile Asp Asn Asp Gly Phe Glu 
    370                 375                 380                 


Asp Val Ala Ile Gly Ala Pro Gln Glu Asp Asp Leu Gln Gly Ala Ile 
385                 390                 395                 400 


Tyr Ile Tyr Asn Gly Arg Ala Asp Gly Ile Ser Ser Thr Phe Ser Gln 
                405                 410                 415     


Arg Ile Glu Gly Leu Gln Ile Ser Lys Ser Leu Ser Met Phe Gly Gln 
            420                 425                 430         


Ser Ile Ser Gly Gln Ile Asp Ala Asp Asn Asn Gly Tyr Val Asp Val 
        435                 440                 445             


Ala Val Gly Ala Phe Arg Ser Asp Ser Ala Val Leu Leu Arg Thr Arg 
    450                 455                 460                 


Pro Val Val Ile Val Asp Ala Ser Leu Ser His Pro Glu Ser Val Asn 
465                 470                 475                 480 


Arg Thr Lys Phe Asp Cys Val Glu Asn Gly Trp Pro Ser Val Cys Ile 
                485                 490                 495     


Asp Leu Thr Leu Cys Phe Ser Tyr Lys Gly Lys Glu Val Pro Gly Tyr 
            500                 505                 510         


Ile Val Leu Phe Tyr Asn Met Ser Leu Asp Val Asn Arg Lys Ala Glu 
        515                 520                 525             


Ser Pro Pro Arg Phe Tyr Phe Ser Ser Asn Gly Thr Ser Asp Val Ile 
    530                 535                 540                 


Thr Gly Ser Ile Gln Val Ser Ser Arg Glu Ala Asn Cys Arg Thr His 
545                 550                 555                 560 


Gln Ala Phe Met Arg Lys Asp Val Arg Asp Ile Leu Thr Pro Ile Gln 
                565                 570                 575     


Ile Glu Ala Ala Tyr His Leu Gly Pro His Val Ile Ser Lys Arg Ser 
            580                 585                 590         


Thr Glu Glu Phe Pro Pro Leu Gln Pro Ile Leu Gln Gln Lys Lys Glu 
        595                 600                 605             


Lys Asp Ile Met Lys Lys Thr Ile Asn Phe Ala Arg Phe Cys Ala His 
    610                 615                 620                 


Glu Asn Cys Ser Ala Asp Leu Gln Val Ser Ala Lys Ile Gly Phe Leu 
625                 630                 635                 640 


Lys Pro His Glu Asn Lys Thr Tyr Leu Ala Val Gly Ser Met Lys Thr 
                645                 650                 655     


Leu Met Leu Asn Val Ser Leu Phe Asn Ala Gly Asp Asp Ala Tyr Glu 
            660                 665                 670         


Thr Thr Leu His Val Lys Leu Pro Val Gly Leu Tyr Phe Ile Lys Ile 
        675                 680                 685             


Leu Glu Leu Glu Glu Lys Gln Ile Asn Cys Glu Val Thr Asp Asn Ser 
    690                 695                 700                 


Gly Val Val Gln Leu Asp Cys Ser Ile Gly Tyr Ile Tyr Val Asp His 
705                 710                 715                 720 


Leu Ser Arg Ile Asp Ile Ser Phe Leu Leu Asp Val Ser Ser Leu Ser 
                725                 730                 735     


Arg Ala Glu Glu Asp Leu Ser Ile Thr Val His Ala Thr Cys Glu Asn 
            740                 745                 750         


Glu Glu Glu Met Asp Asn Leu Lys His Ser Arg Val Thr Val Ala Ile 
        755                 760                 765             


Pro Leu Lys Tyr Glu Val Lys Leu Thr Val His Gly Phe Val Asn Pro 
    770                 775                 780                 


Thr Ser Phe Val Tyr Gly Ser Asn Asp Glu Asn Glu Pro Glu Thr Cys 
785                 790                 795                 800 


Met Val Glu Lys Met Asn Leu Thr Phe His Val Ile Asn Thr Gly Asn 
                805                 810                 815     


Ser Met Ala Pro Asn Val Ser Val Glu Ile Met Val Pro Asn Ser Phe 
            820                 825                 830         


Ser Pro Gln Thr Asp Lys Leu Phe Asn Ile Leu Asp Val Gln Thr Thr 
        835                 840                 845             


Thr Gly Glu Cys His Phe Glu Asn Tyr Gln Arg Val Cys Ala Leu Glu 
    850                 855                 860                 


Gln Gln Lys Ser Ala Met Gln Thr Leu Lys Gly Ile Val Arg Phe Leu 
865                 870                 875                 880 


Ser Lys Thr Asp Lys Arg Leu Leu Tyr Cys Ile Lys Ala Asp Pro His 
                885                 890                 895     


Cys Leu Asn Phe Leu Cys Asn Phe Gly Lys Met Glu Ser Gly Lys Glu 
            900                 905                 910         


Ala Ser Val His Ile Gln Leu Glu Gly Arg Pro Ser Ile Leu Glu Met 
        915                 920                 925             


Asp Glu Thr Ser Ala Leu Lys Phe Glu Ile Arg Ala Thr Gly Phe Pro 
    930                 935                 940                 


Glu Pro Asn Pro Arg Val Ile Glu Leu Asn Lys Asp Glu Asn Val Ala 
945                 950                 955                 960 


His Val Leu Leu Glu Gly Leu His His Gln Arg Pro Lys Arg Tyr Phe 
                965                 970                 975     


Thr Ile Val Ile Ile Ser Ser Ser Leu Leu Leu Gly Leu Ile Val Leu 
            980                 985                 990         


Leu Leu Ile Ser Tyr Val Met Trp  Lys Ala Gly Phe Phe  Lys Arg Gln 
        995                 1000                 1005             


Tyr Lys  Ser Ile Leu Gln Glu  Glu Asn Arg Arg Asp  Ser Trp Ser 
    1010                 1015                 1020             


Tyr Ile  Asn Ser Lys Ser Asn  Asp Asp 
    1025                 1030         


<210>  312
<211>  1163
<212>  PRT
<213>  Homo sapiens

<400>  312

Met Thr Arg Thr Arg Ala Ala Leu Leu Leu Phe Thr Ala Leu Ala Thr 
1               5                   10                  15      


Ser Leu Gly Phe Asn Leu Asp Thr Glu Glu Leu Thr Ala Phe Arg Val 
            20                  25                  30          


Asp Ser Ala Gly Phe Gly Asp Ser Val Val Gln Tyr Ala Asn Ser Trp 
        35                  40                  45              


Val Val Val Gly Ala Pro Gln Lys Ile Thr Ala Ala Asn Gln Thr Gly 
    50                  55                  60                  


Gly Leu Tyr Gln Cys Gly Tyr Ser Thr Gly Ala Cys Glu Pro Ile Gly 
65                  70                  75                  80  


Leu Gln Val Pro Pro Glu Ala Val Asn Met Ser Leu Gly Leu Ser Leu 
                85                  90                  95      


Ala Ser Thr Thr Ser Pro Ser Gln Leu Leu Ala Cys Gly Pro Thr Val 
            100                 105                 110         


His His Glu Cys Gly Arg Asn Met Tyr Leu Thr Gly Leu Cys Phe Leu 
        115                 120                 125             


Leu Gly Pro Thr Gln Leu Thr Gln Arg Leu Pro Val Ser Arg Gln Glu 
    130                 135                 140                 


Cys Pro Arg Gln Glu Gln Asp Ile Val Phe Leu Ile Asp Gly Ser Gly 
145                 150                 155                 160 


Ser Ile Ser Ser Arg Asn Phe Ala Thr Met Met Asn Phe Val Arg Ala 
                165                 170                 175     


Val Ile Ser Gln Phe Gln Arg Pro Ser Thr Gln Phe Ser Leu Met Gln 
            180                 185                 190         


Phe Ser Asn Lys Phe Gln Thr His Phe Thr Phe Glu Glu Phe Arg Arg 
        195                 200                 205             


Ser Ser Asn Pro Leu Ser Leu Leu Ala Ser Val His Gln Leu Gln Gly 
    210                 215                 220                 


Phe Thr Tyr Thr Ala Thr Ala Ile Gln Asn Val Val His Arg Leu Phe 
225                 230                 235                 240 


His Ala Ser Tyr Gly Ala Arg Arg Asp Ala Ala Lys Ile Leu Ile Val 
                245                 250                 255     


Ile Thr Asp Gly Lys Lys Glu Gly Asp Ser Leu Asp Tyr Lys Asp Val 
            260                 265                 270         


Ile Pro Met Ala Asp Ala Ala Gly Ile Ile Arg Tyr Ala Ile Gly Val 
        275                 280                 285             


Gly Leu Ala Phe Gln Asn Arg Asn Ser Trp Lys Glu Leu Asn Asp Ile 
    290                 295                 300                 


Ala Ser Lys Pro Ser Gln Glu His Ile Phe Lys Val Glu Asp Phe Asp 
305                 310                 315                 320 


Ala Leu Lys Asp Ile Gln Asn Gln Leu Lys Glu Lys Ile Phe Ala Ile 
                325                 330                 335     


Glu Gly Thr Glu Thr Thr Ser Ser Ser Ser Phe Glu Leu Glu Met Ala 
            340                 345                 350         


Gln Glu Gly Phe Ser Ala Val Phe Thr Pro Asp Gly Pro Val Leu Gly 
        355                 360                 365             


Ala Val Gly Ser Phe Thr Trp Ser Gly Gly Ala Phe Leu Tyr Pro Pro 
    370                 375                 380                 


Asn Met Ser Pro Thr Phe Ile Asn Met Ser Gln Glu Asn Val Asp Met 
385                 390                 395                 400 


Arg Asp Ser Tyr Leu Gly Tyr Ser Thr Glu Leu Ala Leu Trp Lys Gly 
                405                 410                 415     


Val Gln Ser Leu Val Leu Gly Ala Pro Arg Tyr Gln His Thr Gly Lys 
            420                 425                 430         


Ala Val Ile Phe Thr Gln Val Ser Arg Gln Trp Arg Met Lys Ala Glu 
        435                 440                 445             


Val Thr Gly Thr Gln Ile Gly Ser Tyr Phe Gly Ala Ser Leu Cys Ser 
    450                 455                 460                 


Val Asp Val Asp Ser Asp Gly Ser Thr Asp Leu Val Leu Ile Gly Ala 
465                 470                 475                 480 


Pro His Tyr Tyr Glu Gln Thr Arg Gly Gly Gln Val Ser Val Cys Pro 
                485                 490                 495     


Leu Pro Arg Gly Trp Arg Arg Trp Trp Cys Asp Ala Val Leu Tyr Gly 
            500                 505                 510         


Glu Gln Gly His Pro Trp Gly Arg Phe Gly Ala Ala Leu Thr Val Leu 
        515                 520                 525             


Gly Asp Val Asn Gly Asp Lys Leu Thr Asp Val Val Ile Gly Ala Pro 
    530                 535                 540                 


Gly Glu Glu Glu Asn Arg Gly Ala Val Tyr Leu Phe His Gly Val Leu 
545                 550                 555                 560 


Gly Pro Ser Ile Ser Pro Ser His Ser Gln Arg Ile Ala Gly Ser Gln 
                565                 570                 575     


Leu Ser Ser Arg Leu Gln Tyr Phe Gly Gln Ala Leu Ser Gly Gly Gln 
            580                 585                 590         


Asp Leu Thr Gln Asp Gly Leu Val Asp Leu Ala Val Gly Ala Arg Gly 
        595                 600                 605             


Gln Val Leu Leu Leu Arg Thr Arg Pro Val Leu Trp Val Gly Val Ser 
    610                 615                 620                 


Met Gln Phe Ile Pro Ala Glu Ile Pro Arg Ser Ala Phe Glu Cys Arg 
625                 630                 635                 640 


Glu Gln Val Val Ser Glu Gln Thr Leu Val Gln Ser Asn Ile Cys Leu 
                645                 650                 655     


Tyr Ile Asp Lys Arg Ser Lys Asn Leu Leu Gly Ser Arg Asp Leu Gln 
            660                 665                 670         


Ser Ser Val Thr Leu Asp Leu Ala Leu Asp Pro Gly Arg Leu Ser Pro 
        675                 680                 685             


Arg Ala Thr Phe Gln Glu Thr Lys Asn Arg Ser Leu Ser Arg Val Arg 
    690                 695                 700                 


Val Leu Gly Leu Lys Ala His Cys Glu Asn Phe Asn Leu Leu Leu Pro 
705                 710                 715                 720 


Ser Cys Val Glu Asp Ser Val Thr Pro Ile Thr Leu Arg Leu Asn Phe 
                725                 730                 735     


Thr Leu Val Gly Lys Pro Leu Leu Ala Phe Arg Asn Leu Arg Pro Met 
            740                 745                 750         


Leu Ala Ala Asp Ala Gln Arg Tyr Phe Thr Ala Ser Leu Pro Phe Glu 
        755                 760                 765             


Lys Asn Cys Gly Ala Asp His Ile Cys Gln Asp Asn Leu Gly Ile Ser 
    770                 775                 780                 


Phe Ser Phe Pro Gly Leu Lys Ser Leu Leu Val Gly Ser Asn Leu Glu 
785                 790                 795                 800 


Leu Asn Ala Glu Val Met Val Trp Asn Asp Gly Glu Asp Ser Tyr Gly 
                805                 810                 815     


Thr Thr Ile Thr Phe Ser His Pro Ala Gly Leu Ser Tyr Arg Tyr Val 
            820                 825                 830         


Ala Glu Gly Gln Lys Gln Gly Gln Leu Arg Ser Leu His Leu Thr Cys 
        835                 840                 845             


Asp Ser Ala Pro Val Gly Ser Gln Gly Thr Trp Ser Thr Ser Cys Arg 
    850                 855                 860                 


Ile Asn His Leu Ile Phe Arg Gly Gly Ala Gln Ile Thr Phe Leu Ala 
865                 870                 875                 880 


Thr Phe Asp Val Ser Pro Lys Ala Val Leu Gly Asp Arg Leu Leu Leu 
                885                 890                 895     


Thr Ala Asn Val Ser Ser Glu Asn Asn Thr Pro Arg Thr Ser Lys Thr 
            900                 905                 910         


Thr Phe Gln Leu Glu Leu Pro Val Lys Tyr Ala Val Tyr Thr Val Val 
        915                 920                 925             


Ser Ser His Glu Gln Phe Thr Lys Tyr Leu Asn Phe Ser Glu Ser Glu 
    930                 935                 940                 


Glu Lys Glu Ser His Val Ala Met His Arg Tyr Gln Val Asn Asn Leu 
945                 950                 955                 960 


Gly Gln Arg Asp Leu Pro Val Ser Ile Asn Phe Trp Val Pro Val Glu 
                965                 970                 975     


Leu Asn Gln Glu Ala Val Trp Met Asp Val Glu Val Ser His Pro Gln 
            980                 985                 990         


Asn Pro Ser Leu Arg Cys Ser Ser  Glu Lys Ile Ala Pro  Pro Ala Ser 
        995                 1000                 1005             


Asp Phe  Leu Ala His Ile Gln  Lys Asn Pro Val Leu  Asp Cys Ser 
    1010                 1015                 1020             


Ile Ala  Gly Cys Leu Arg Phe  Arg Cys Asp Val Pro  Ser Phe Ser 
    1025                 1030                 1035             


Val Gln  Glu Glu Leu Asp Phe  Thr Leu Lys Gly Asn  Leu Ser Phe 
    1040                 1045                 1050             


Gly Trp  Val Arg Gln Ile Leu  Gln Lys Lys Val Ser  Val Val Ser 
    1055                 1060                 1065             


Val Ala  Glu Ile Thr Phe Asp  Thr Ser Val Tyr Ser  Gln Leu Pro 
    1070                 1075                 1080             


Gly Gln  Glu Ala Phe Met Arg  Ala Gln Thr Thr Thr  Val Leu Glu 
    1085                 1090                 1095             


Lys Tyr  Lys Val His Asn Pro  Thr Pro Leu Ile Val  Gly Ser Ser 
    1100                 1105                 1110             


Ile Gly  Gly Leu Leu Leu Leu  Ala Leu Ile Thr Ala  Val Leu Tyr 
    1115                 1120                 1125             


Lys Val  Gly Phe Phe Lys Arg  Gln Tyr Lys Glu Met  Met Glu Glu 
    1130                 1135                 1140             


Ala Asn  Gly Gln Ile Ala Pro  Glu Asn Gly Thr Gln  Thr Pro Ser 
    1145                 1150                 1155             


Pro Pro  Ser Glu Lys 
    1160             


<210>  313
<211>  788
<212>  PRT
<213>  Homo sapiens

<400>  313

Met Gly Ile Glu Leu Leu Cys Leu Phe Phe Leu Phe Leu Gly Arg Asn 
1               5                   10                  15      


Asp His Val Gln Gly Gly Cys Ala Leu Gly Gly Ala Glu Thr Cys Glu 
            20                  25                  30          


Asp Cys Leu Leu Ile Gly Pro Gln Cys Ala Trp Cys Ala Gln Glu Asn 
        35                  40                  45              


Phe Thr His Pro Ser Gly Val Gly Glu Arg Cys Asp Thr Pro Ala Asn 
    50                  55                  60                  


Leu Leu Ala Lys Gly Cys Gln Leu Asn Phe Ile Glu Asn Pro Val Ser 
65                  70                  75                  80  


Gln Val Glu Ile Leu Lys Asn Lys Pro Leu Ser Val Gly Arg Gln Lys 
                85                  90                  95      


Asn Ser Ser Asp Ile Val Gln Ile Ala Pro Gln Ser Leu Ile Leu Lys 
            100                 105                 110         


Leu Arg Pro Gly Gly Ala Gln Thr Leu Gln Val His Val Arg Gln Thr 
        115                 120                 125             


Glu Asp Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu Ser Ala Ser 
    130                 135                 140                 


Met Asp Asp Asp Leu Asn Thr Ile Lys Glu Leu Gly Ser Arg Leu Ser 
145                 150                 155                 160 


Lys Glu Met Ser Lys Leu Thr Ser Asn Phe Arg Leu Gly Phe Gly Ser 
                165                 170                 175     


Phe Val Glu Lys Pro Val Ser Pro Phe Val Lys Thr Thr Pro Glu Glu 
            180                 185                 190         


Ile Ala Asn Pro Cys Ser Ser Ile Pro Tyr Phe Cys Leu Pro Thr Phe 
        195                 200                 205             


Gly Phe Lys His Ile Leu Pro Leu Thr Asn Asp Ala Glu Arg Phe Asn 
    210                 215                 220                 


Glu Ile Val Lys Asn Gln Lys Ile Ser Ala Asn Ile Asp Thr Pro Glu 
225                 230                 235                 240 


Gly Gly Phe Asp Ala Ile Met Gln Ala Ala Val Cys Lys Glu Lys Ile 
                245                 250                 255     


Gly Trp Arg Asn Asp Ser Leu His Leu Leu Val Phe Val Ser Asp Ala 
            260                 265                 270         


Asp Ser His Phe Gly Met Asp Ser Lys Leu Ala Gly Ile Val Ile Pro 
        275                 280                 285             


Asn Asp Gly Leu Cys His Leu Asp Ser Lys Asn Glu Tyr Ser Met Ser 
    290                 295                 300                 


Thr Val Leu Glu Tyr Pro Thr Ile Gly Gln Leu Ile Asp Lys Leu Val 
305                 310                 315                 320 


Gln Asn Asn Val Leu Leu Ile Phe Ala Val Thr Gln Glu Gln Val His 
                325                 330                 335     


Leu Tyr Glu Asn Tyr Ala Lys Leu Ile Pro Gly Ala Thr Val Gly Leu 
            340                 345                 350         


Leu Gln Lys Asp Ser Gly Asn Ile Leu Gln Leu Ile Ile Ser Ala Tyr 
        355                 360                 365             


Glu Glu Leu Arg Ser Glu Val Glu Leu Glu Val Leu Gly Asp Thr Glu 
    370                 375                 380                 


Gly Leu Asn Leu Ser Phe Thr Ala Ile Cys Asn Asn Gly Thr Leu Phe 
385                 390                 395                 400 


Gln His Gln Lys Lys Cys Ser His Met Lys Val Gly Asp Thr Ala Ser 
                405                 410                 415     


Phe Ser Val Thr Val Asn Ile Pro His Cys Glu Arg Arg Ser Arg His 
            420                 425                 430         


Ile Ile Ile Lys Pro Val Gly Leu Gly Asp Ala Leu Glu Leu Leu Val 
        435                 440                 445             


Ser Pro Glu Cys Asn Cys Asp Cys Gln Lys Glu Val Glu Val Asn Ser 
    450                 455                 460                 


Ser Lys Cys His His Gly Asn Gly Ser Phe Gln Cys Gly Val Cys Ala 
465                 470                 475                 480 


Cys His Pro Gly His Met Gly Pro Arg Cys Glu Cys Gly Glu Asp Met 
                485                 490                 495     


Leu Ser Thr Asp Ser Cys Lys Glu Ala Pro Asp His Pro Ser Cys Ser 
            500                 505                 510         


Gly Arg Gly Asp Cys Tyr Cys Gly Gln Cys Ile Cys His Leu Ser Pro 
        515                 520                 525             


Tyr Gly Asn Ile Tyr Gly Pro Tyr Cys Gln Cys Asp Asn Phe Ser Cys 
    530                 535                 540                 


Val Arg His Lys Gly Leu Leu Cys Gly Gly Asn Gly Asp Cys Asp Cys 
545                 550                 555                 560 


Gly Glu Cys Val Cys Arg Ser Gly Trp Thr Gly Glu Tyr Cys Asn Cys 
                565                 570                 575     


Thr Thr Ser Thr Asp Ser Cys Val Ser Glu Asp Gly Val Leu Cys Ser 
            580                 585                 590         


Gly Arg Gly Asp Cys Val Cys Gly Lys Cys Val Cys Thr Asn Pro Gly 
        595                 600                 605             


Ala Ser Gly Pro Thr Cys Glu Arg Cys Pro Thr Cys Gly Asp Pro Cys 
    610                 615                 620                 


Asn Ser Lys Arg Ser Cys Ile Glu Cys His Leu Ser Ala Ala Gly Gln 
625                 630                 635                 640 


Ala Arg Glu Glu Cys Val Asp Lys Cys Lys Leu Ala Gly Ala Thr Ile 
                645                 650                 655     


Ser Glu Glu Glu Asp Phe Ser Lys Asp Gly Ser Val Ser Cys Ser Leu 
            660                 665                 670         


Gln Gly Glu Asn Glu Cys Leu Ile Thr Phe Leu Ile Thr Thr Asp Asn 
        675                 680                 685             


Glu Gly Lys Thr Ile Ile His Ser Ile Asn Glu Lys Asp Cys Pro Lys 
    690                 695                 700                 


Pro Pro Asn Ile Pro Met Ile Met Leu Gly Val Ser Leu Ala Ile Leu 
705                 710                 715                 720 


Leu Ile Gly Val Val Leu Leu Cys Ile Trp Lys Leu Leu Val Ser Phe 
                725                 730                 735     


His Asp Arg Lys Glu Val Ala Lys Phe Glu Ala Glu Arg Ser Lys Ala 
            740                 745                 750         


Lys Trp Gln Thr Gly Thr Asn Pro Leu Tyr Arg Gly Ser Thr Ser Thr 
        755                 760                 765             


Phe Lys Asn Val Thr Tyr Lys His Arg Glu Lys Gln Lys Val Asp Leu 
    770                 775                 780                 


Ser Thr Asp Cys 
785             


<210>  314
<211>  798
<212>  PRT
<213>  Homo sapiens

<400>  314

Met Val Ala Leu Pro Met Val Leu Val Leu Leu Leu Val Leu Ser Arg 
1               5                   10                  15      


Gly Glu Ser Glu Leu Asp Ala Lys Ile Pro Ser Thr Gly Asp Ala Thr 
            20                  25                  30          


Glu Trp Arg Asn Pro His Leu Ser Met Leu Gly Ser Cys Gln Pro Ala 
        35                  40                  45              


Pro Ser Cys Gln Lys Cys Ile Leu Ser His Pro Ser Cys Ala Trp Cys 
    50                  55                  60                  


Lys Gln Leu Asn Phe Thr Ala Ser Gly Glu Ala Glu Ala Arg Arg Cys 
65                  70                  75                  80  


Ala Arg Arg Glu Glu Leu Leu Ala Arg Gly Cys Pro Leu Glu Glu Leu 
                85                  90                  95      


Glu Glu Pro Arg Gly Gln Gln Glu Val Leu Gln Asp Gln Pro Leu Ser 
            100                 105                 110         


Gln Gly Ala Arg Gly Glu Gly Ala Thr Gln Leu Ala Pro Gln Arg Val 
        115                 120                 125             


Arg Val Thr Leu Arg Pro Gly Glu Pro Gln Gln Leu Gln Val Arg Phe 
    130                 135                 140                 


Leu Arg Ala Glu Gly Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu 
145                 150                 155                 160 


Ser Tyr Ser Met Lys Asp Asp Leu Glu Arg Val Arg Gln Leu Gly His 
                165                 170                 175     


Ala Leu Leu Val Arg Leu Gln Glu Val Thr His Ser Val Arg Ile Gly 
            180                 185                 190         


Phe Gly Ser Phe Val Asp Lys Thr Val Leu Pro Phe Val Ser Thr Val 
        195                 200                 205             


Pro Ser Lys Leu Arg His Pro Cys Pro Thr Arg Leu Glu Arg Cys Gln 
    210                 215                 220                 


Ser Pro Phe Ser Phe His His Val Leu Ser Leu Thr Gly Asp Ala Gln 
225                 230                 235                 240 


Ala Phe Glu Arg Glu Val Gly Arg Gln Ser Val Ser Gly Asn Leu Asp 
                245                 250                 255     


Ser Pro Glu Gly Gly Phe Asp Ala Ile Leu Gln Ala Ala Leu Cys Gln 
            260                 265                 270         


Glu Gln Ile Gly Trp Arg Asn Val Ser Arg Leu Leu Val Phe Thr Ser 
        275                 280                 285             


Asp Asp Thr Phe His Thr Ala Gly Asp Gly Lys Leu Gly Gly Ile Phe 
    290                 295                 300                 


Met Pro Ser Asp Gly His Cys His Leu Asp Ser Asn Gly Leu Tyr Ser 
305                 310                 315                 320 


Arg Ser Thr Glu Phe Asp Tyr Pro Ser Val Gly Gln Val Ala Gln Ala 
                325                 330                 335     


Leu Ser Ala Ala Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Ala Ala 
            340                 345                 350         


Leu Pro Val Tyr Gln Glu Leu Ser Lys Leu Ile Pro Lys Ser Ala Val 
        355                 360                 365             


Gly Glu Leu Ser Glu Asp Ser Ser Asn Val Val Gln Leu Ile Met Asp 
    370                 375                 380                 


Ala Tyr Asn Ser Leu Ser Ser Thr Val Thr Leu Glu His Ser Ser Leu 
385                 390                 395                 400 


Pro Pro Gly Val His Ile Ser Tyr Glu Ser Gln Cys Glu Gly Pro Glu 
                405                 410                 415     


Lys Arg Glu Gly Lys Ala Glu Asp Arg Gly Gln Cys Asn His Val Arg 
            420                 425                 430         


Ile Asn Gln Thr Val Thr Phe Trp Val Ser Leu Gln Ala Thr His Cys 
        435                 440                 445             


Leu Pro Glu Pro His Leu Leu Arg Leu Arg Ala Leu Gly Phe Ser Glu 
    450                 455                 460                 


Glu Leu Ile Val Glu Leu His Thr Leu Cys Asp Cys Asn Cys Ser Asp 
465                 470                 475                 480 


Thr Gln Pro Gln Ala Pro His Cys Ser Asp Gly Gln Gly His Leu Gln 
                485                 490                 495     


Cys Gly Val Cys Ser Cys Ala Pro Gly Arg Leu Gly Arg Leu Cys Glu 
            500                 505                 510         


Cys Ser Val Ala Glu Leu Ser Ser Pro Asp Leu Glu Ser Gly Cys Arg 
        515                 520                 525             


Ala Pro Asn Gly Thr Gly Pro Leu Cys Ser Gly Lys Gly His Cys Gln 
    530                 535                 540                 


Cys Gly Arg Cys Ser Cys Ser Gly Gln Ser Ser Gly His Leu Cys Glu 
545                 550                 555                 560 


Cys Asp Asp Ala Ser Cys Glu Arg His Glu Gly Ile Leu Cys Gly Gly 
                565                 570                 575     


Phe Gly Arg Cys Gln Cys Gly Val Cys His Cys His Ala Asn Arg Thr 
            580                 585                 590         


Gly Arg Ala Cys Glu Cys Ser Gly Asp Met Asp Ser Cys Ile Ser Pro 
        595                 600                 605             


Glu Gly Gly Leu Cys Ser Gly His Gly Arg Cys Lys Cys Asn Arg Cys 
    610                 615                 620                 


Gln Cys Leu Asp Gly Tyr Tyr Gly Ala Leu Cys Asp Gln Cys Pro Gly 
625                 630                 635                 640 


Cys Lys Thr Pro Cys Glu Arg His Arg Asp Cys Ala Glu Cys Gly Ala 
                645                 650                 655     


Phe Arg Thr Gly Pro Leu Ala Thr Asn Cys Ser Thr Ala Cys Ala His 
            660                 665                 670         


Thr Asn Val Thr Leu Ala Leu Ala Pro Ile Leu Asp Asp Gly Trp Cys 
        675                 680                 685             


Lys Glu Arg Thr Leu Asp Asn Gln Leu Phe Phe Phe Leu Val Glu Asp 
    690                 695                 700                 


Asp Ala Arg Gly Thr Val Val Leu Arg Val Arg Pro Gln Glu Lys Gly 
705                 710                 715                 720 


Ala Asp His Thr Gln Ala Ile Val Leu Gly Cys Val Gly Gly Ile Val 
                725                 730                 735     


Ala Val Gly Leu Gly Leu Val Leu Ala Tyr Arg Leu Ser Val Glu Ile 
            740                 745                 750         


Tyr Asp Arg Arg Glu Tyr Ser Arg Phe Glu Lys Glu Gln Gln Gln Leu 
        755                 760                 765             


Asn Trp Lys Gln Asp Ser Asn Pro Leu Tyr Lys Ser Ala Ile Thr Thr 
    770                 775                 780                 


Thr Ile Asn Pro Arg Phe Gln Glu Ala Asp Ser Pro Thr Leu 
785                 790                 795             


<210>  315
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  315

Met Ala Gly Asp Ser Arg Asn Ala Met Asn Gln Asp Met Glu Ile Gly 
1               5                   10                  15      


Val Thr Pro Trp Asp Pro Lys Lys Ile Pro Lys Gln Ala Arg Asp Tyr 
            20                  25                  30          


Val Pro Ile Ala Thr Asp Arg Thr Arg Leu Leu Ala Glu Gly Lys Lys 
        35                  40                  45              


Pro Arg Gln Arg Tyr Met Glu Lys Ser Gly Lys Cys Asn Val His His 
    50                  55                  60                  


Gly Asn Val Gln Glu Thr Tyr Arg Tyr Leu Ser Asp Leu Phe Thr Thr 
65                  70                  75                  80  


Leu Val Asp Leu Lys Trp Arg Phe Asn Leu Leu Val Phe Thr Met Val 
                85                  90                  95      


Tyr Thr Val Thr Trp Leu Phe Phe Gly Phe Ile Trp Trp Leu Ile Ala 
            100                 105                 110         


Tyr Ile Arg Gly Asp Leu Asp His Val Gly Asp Gln Glu Trp Ile Pro 
        115                 120                 125             


Cys Val Glu Asn Leu Ser Gly Phe Val Ser Ala Phe Leu Phe Ser Ile 
    130                 135                 140                 


Glu Thr Glu Thr Thr Ile Gly Tyr Gly Phe Arg Val Ile Thr Glu Lys 
145                 150                 155                 160 


Cys Pro Glu Gly Ile Ile Leu Leu Leu Val Gln Ala Ile Leu Gly Ser 
                165                 170                 175     


Ile Val Asn Ala Phe Met Val Gly Cys Met Phe Val Lys Ile Ser Gln 
            180                 185                 190         


Pro Lys Lys Arg Ala Glu Thr Leu Met Phe Ser Asn Asn Ala Val Ile 
        195                 200                 205             


Ser Met Arg Asp Glu Lys Leu Cys Leu Met Phe Arg Val Gly Asp Leu 
    210                 215                 220                 


Arg Asn Ser His Ile Val Glu Ala Ser Ile Arg Ala Lys Leu Ile Lys 
225                 230                 235                 240 


Ser Arg Gln Thr Lys Glu Gly Glu Phe Ile Pro Leu Asn Gln Thr Asp 
                245                 250                 255     


Ile Asn Val Gly Phe Asp Thr Gly Asp Asp Arg Leu Phe Leu Val Ser 
            260                 265                 270         


Pro Leu Ile Ile Ser His Glu Ile Asn Gln Lys Ser Pro Phe Trp Glu 
        275                 280                 285             


Met Ser Gln Ala Gln Leu His Gln Glu Glu Phe Glu Val Val Val Ile 
    290                 295                 300                 


Leu Glu Gly Met Val Glu Ala Thr Gly Met Thr Cys Gln Ala Arg Ser 
305                 310                 315                 320 


Ser Tyr Met Asp Thr Glu Val Leu Trp Gly His Arg Phe Thr Pro Val 
                325                 330                 335     


Leu Thr Leu Glu Lys Gly Phe Tyr Glu Val Asp Tyr Asn Thr Phe His 
            340                 345                 350         


Asp Thr Tyr Glu Thr Asn Thr Pro Ser Cys Cys Ala Lys Glu Leu Ala 
        355                 360                 365             


Glu Met Lys Arg Glu Gly Arg Leu Leu Gln Tyr Leu Pro Ser Pro Pro 
    370                 375                 380                 


Leu Leu Gly Gly Cys Ala Glu Ala Gly Leu Asp Ala Glu Ala Glu Gln 
385                 390                 395                 400 


Asn Glu Glu Asp Glu Pro Lys Gly Leu Gly Gly Ser Arg Glu Ala Arg 
                405                 410                 415     


Gly Ser Val 
            


<210>  316
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  316

Met Gly Ser Val Arg Thr Asn Arg Tyr Ser Ile Val Ser Ser Glu Glu 
1               5                   10                  15      


Asp Gly Met Lys Leu Ala Thr Met Ala Val Ala Asn Gly Phe Gly Asn 
            20                  25                  30          


Gly Lys Ser Lys Val His Thr Arg Gln Gln Cys Arg Ser Arg Phe Val 
        35                  40                  45              


Lys Lys Asp Gly His Cys Asn Val Gln Phe Ile Asn Val Gly Glu Lys 
    50                  55                  60                  


Gly Gln Arg Tyr Leu Ala Asp Ile Phe Thr Thr Cys Val Asp Ile Arg 
65                  70                  75                  80  


Trp Arg Trp Met Leu Val Ile Phe Cys Leu Ala Phe Val Leu Ser Trp 
                85                  90                  95      


Leu Phe Phe Gly Cys Val Phe Trp Leu Ile Ala Leu Leu His Gly Asp 
            100                 105                 110         


Leu Asp Ala Ser Lys Glu Gly Lys Ala Cys Val Ser Glu Val Asn Ser 
        115                 120                 125             


Phe Thr Ala Ala Phe Leu Phe Ser Ile Glu Thr Gln Thr Thr Ile Gly 
    130                 135                 140                 


Tyr Gly Phe Arg Cys Val Thr Asp Glu Cys Pro Ile Ala Val Phe Met 
145                 150                 155                 160 


Val Val Phe Gln Ser Ile Val Gly Cys Ile Ile Asp Ala Phe Ile Ile 
                165                 170                 175     


Gly Ala Val Met Ala Lys Met Ala Lys Pro Lys Lys Arg Asn Glu Thr 
            180                 185                 190         


Leu Val Phe Ser His Asn Ala Val Ile Ala Met Arg Asp Gly Lys Leu 
        195                 200                 205             


Cys Leu Met Trp Arg Val Gly Asn Leu Arg Lys Ser His Leu Val Glu 
    210                 215                 220                 


Ala His Val Arg Ala Gln Leu Leu Lys Ser Arg Ile Thr Ser Glu Gly 
225                 230                 235                 240 


Glu Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asn Val Gly Phe Asp Ser 
                245                 250                 255     


Gly Ile Asp Arg Ile Phe Leu Val Ser Pro Ile Thr Ile Val His Glu 
            260                 265                 270         


Ile Asp Glu Asp Ser Pro Leu Tyr Asp Leu Ser Lys Gln Asp Ile Asp 
        275                 280                 285             


Asn Ala Asp Phe Glu Ile Val Val Ile Leu Glu Gly Met Val Glu Ala 
    290                 295                 300                 


Thr Ala Met Thr Thr Gln Cys Arg Ser Ser Tyr Leu Ala Asn Glu Ile 
305                 310                 315                 320 


Leu Trp Gly His Arg Tyr Glu Pro Val Leu Phe Glu Glu Lys His Tyr 
                325                 330                 335     


Tyr Lys Val Asp Tyr Ser Arg Phe His Lys Thr Tyr Glu Val Pro Asn 
            340                 345                 350         


Thr Pro Leu Cys Ser Ala Arg Asp Leu Ala Glu Lys Lys Tyr Ile Leu 
        355                 360                 365             


Ser Asn Ala Asn Ser Phe Cys Tyr Glu Asn Glu Val Ala Leu Thr Ser 
    370                 375                 380                 


Lys Glu Glu Asp Asp Ser Glu Asn Gly Val Pro Glu Ser Thr Ser Thr 
385                 390                 395                 400 


Asp Thr Pro Pro Asp Ile Asp Leu His Asn Gln Ala Ser Val Pro Leu 
                405                 410                 415     


Glu Pro Arg Pro Leu Arg Arg Glu Ser Glu Ile 
            420                 425         


<210>  317
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  317

Met Ser Asn Lys Cys Asp Val Val Val Val Gly Gly Gly Ile Ser Gly 
1               5                   10                  15      


Met Ala Ala Ala Lys Leu Leu His Asp Ser Gly Leu Asn Val Val Val 
            20                  25                  30          


Leu Glu Ala Arg Asp Arg Val Gly Gly Arg Thr Tyr Thr Leu Arg Asn 
        35                  40                  45              


Gln Lys Val Lys Tyr Val Asp Leu Gly Gly Ser Tyr Val Gly Pro Thr 
    50                  55                  60                  


Gln Asn Arg Ile Leu Arg Leu Ala Lys Glu Leu Gly Leu Glu Thr Tyr 
65                  70                  75                  80  


Lys Val Asn Glu Val Glu Arg Leu Ile His His Val Lys Gly Lys Ser 
                85                  90                  95      


Tyr Pro Phe Arg Gly Pro Phe Pro Pro Val Trp Asn Pro Ile Thr Tyr 
            100                 105                 110         


Leu Asp His Asn Asn Phe Trp Arg Thr Met Asp Asp Met Gly Arg Glu 
        115                 120                 125             


Ile Pro Ser Asp Ala Pro Trp Lys Ala Pro Leu Ala Glu Glu Trp Asp 
    130                 135                 140                 


Asn Met Thr Met Lys Glu Leu Leu Asp Lys Leu Cys Trp Thr Glu Ser 
145                 150                 155                 160 


Ala Lys Gln Leu Ala Thr Leu Phe Val Asn Leu Cys Val Thr Ala Glu 
                165                 170                 175     


Thr His Glu Val Ser Ala Leu Trp Phe Leu Trp Tyr Val Lys Gln Cys 
            180                 185                 190         


Gly Gly Thr Thr Arg Ile Ile Ser Thr Thr Asn Gly Gly Gln Glu Arg 
        195                 200                 205             


Lys Phe Val Gly Gly Ser Gly Gln Val Ser Glu Arg Ile Met Asp Leu 
    210                 215                 220                 


Leu Gly Asp Arg Val Lys Leu Glu Arg Pro Val Ile Tyr Ile Asp Gln 
225                 230                 235                 240 


Thr Arg Glu Asn Val Leu Val Glu Thr Leu Asn His Glu Met Tyr Glu 
                245                 250                 255     


Ala Lys Tyr Val Ile Ser Ala Ile Pro Pro Thr Leu Gly Met Lys Ile 
            260                 265                 270         


His Phe Asn Pro Pro Leu Pro Met Met Arg Asn Gln Met Ile Thr Arg 
        275                 280                 285             


Val Pro Leu Gly Ser Val Ile Lys Cys Ile Val Tyr Tyr Lys Glu Pro 
    290                 295                 300                 


Phe Trp Arg Lys Lys Asp Tyr Cys Gly Thr Met Ile Ile Asp Gly Glu 
305                 310                 315                 320 


Glu Ala Pro Val Ala Tyr Thr Leu Asp Asp Thr Lys Pro Glu Gly Asn 
                325                 330                 335     


Tyr Ala Ala Ile Met Gly Phe Ile Leu Ala His Lys Ala Arg Lys Leu 
            340                 345                 350         


Ala Arg Leu Thr Lys Glu Glu Arg Leu Lys Lys Leu Cys Glu Leu Tyr 
        355                 360                 365             


Ala Lys Val Leu Gly Ser Leu Glu Ala Leu Glu Pro Val His Tyr Glu 
    370                 375                 380                 


Glu Lys Asn Trp Cys Glu Glu Gln Tyr Ser Gly Gly Cys Tyr Thr Thr 
385                 390                 395                 400 


Tyr Phe Pro Pro Gly Ile Leu Thr Gln Tyr Gly Arg Val Leu Arg Gln 
                405                 410                 415     


Pro Val Asp Arg Ile Tyr Phe Ala Gly Thr Glu Thr Ala Thr His Trp 
            420                 425                 430         


Ser Gly Tyr Met Glu Gly Ala Val Glu Ala Gly Glu Arg Ala Ala Arg 
        435                 440                 445             


Glu Ile Leu His Ala Met Gly Lys Ile Pro Glu Asp Glu Ile Trp Gln 
    450                 455                 460                 


Ser Glu Pro Glu Ser Val Asp Val Pro Ala Gln Pro Ile Thr Thr Thr 
465                 470                 475                 480 


Phe Leu Glu Arg His Leu Pro Ser Val Pro Gly Leu Leu Arg Leu Ile 
                485                 490                 495     


Gly Leu Thr Thr Ile Phe Ser Ala Thr Ala Leu Gly Phe Leu Ala His 
            500                 505                 510         


Lys Arg Gly Leu Leu Val Arg Val 
        515                 520 


<210>  318
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  318

Met Lys Lys Thr Gln Thr Trp Ile Leu Thr Cys Ile Tyr Leu Gln Leu 
1               5                   10                  15      


Leu Leu Phe Asn Pro Leu Val Lys Thr Glu Gly Ile Cys Arg Asn Arg 
            20                  25                  30          


Val Thr Asn Asn Val Lys Asp Val Thr Lys Leu Val Ala Asn Leu Pro 
        35                  40                  45              


Lys Asp Tyr Met Ile Thr Leu Lys Tyr Val Pro Gly Met Asp Val Leu 
    50                  55                  60                  


Pro Ser His Cys Trp Ile Ser Glu Met Val Val Gln Leu Ser Asp Ser 
65                  70                  75                  80  


Leu Thr Asp Leu Leu Asp Lys Phe Ser Asn Ile Ser Glu Gly Leu Ser 
                85                  90                  95      


Asn Tyr Ser Ile Ile Asp Lys Leu Val Asn Ile Val Asp Asp Leu Val 
            100                 105                 110         


Glu Cys Val Lys Glu Asn Ser Ser Lys Asp Leu Lys Lys Ser Phe Lys 
        115                 120                 125             


Ser Pro Glu Pro Arg Leu Phe Thr Pro Glu Glu Phe Phe Arg Ile Phe 
    130                 135                 140                 


Asn Arg Ser Ile Asp Ala Phe Lys Asp Phe Val Val Ala Ser Glu Thr 
145                 150                 155                 160 


Ser Asp Cys Val Val Ser Ser Thr Leu Ser Pro Glu Lys Asp Ser Arg 
                165                 170                 175     


Val Ser Val Thr Lys Pro Phe Met Leu Pro Pro Val Ala Ala Ser Ser 
            180                 185                 190         


Leu Arg Asn Asp Ser Ser Ser Ser Asn Arg Lys Ala Lys Asn Pro Pro 
        195                 200                 205             


Gly Asp Ser Ser Leu His Trp Ala Ala Met Ala Leu Pro Ala Leu Phe 
    210                 215                 220                 


Ser Leu Ile Ile Gly Phe Ala Phe Gly Ala Leu Tyr Trp Lys Lys Arg 
225                 230                 235                 240 


Gln Pro Ser Leu Thr Arg Ala Val Glu Asn Ile Gln Ile Asn Glu Glu 
                245                 250                 255     


Asp Asn Glu Ile Ser Met Leu Gln Glu Lys Glu Arg Glu Phe Gln Glu 
            260                 265                 270         


Val 
    


<210>  319
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  319

Met Lys Ser Leu Ile Leu Leu Ala Ile Leu Ala Ala Leu Ala Val Val 
1               5                   10                  15      


Thr Leu Cys Tyr Glu Ser His Glu Ser Met Glu Ser Tyr Glu Leu Asn 
            20                  25                  30          


Pro Phe Ile Asn Arg Arg Asn Ala Asn Thr Phe Ile Ser Pro Gln Gln 
        35                  40                  45              


Arg Trp Arg Ala Lys Val Gln Glu Arg Ile Arg Glu Arg Ser Lys Pro 
    50                  55                  60                  


Val His Glu Leu Asn Arg Glu Ala Cys Asp Asp Tyr Arg Leu Cys Glu 
65                  70                  75                  80  


Arg Tyr Ala Met Val Tyr Gly Tyr Asn Ala Ala Tyr Asn Arg Tyr Phe 
                85                  90                  95      


Arg Lys Arg Arg Gly Thr Lys 
            100             


<210>  320
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  320

Met Gly Lys Ser Glu Ser Gln Met Asp Ile Thr Asp Ile Asn Thr Pro 
1               5                   10                  15      


Lys Pro Lys Lys Lys Gln Arg Trp Thr Pro Leu Glu Ile Ser Leu Ser 
            20                  25                  30          


Val Leu Val Leu Leu Leu Thr Ile Ile Ala Val Thr Met Ile Ala Leu 
        35                  40                  45              


Tyr Ala Thr Tyr Asp Asp Gly Ile Cys Lys Ser Ser Asp Cys Ile Lys 
    50                  55                  60                  


Ser Ala Ala Arg Leu Ile Gln Asn Met Asp Ala Thr Thr Glu Pro Cys 
65                  70                  75                  80  


Thr Asp Phe Phe Lys Tyr Ala Cys Gly Gly Trp Leu Lys Arg Asn Val 
                85                  90                  95      


Ile Pro Glu Thr Ser Ser Arg Tyr Gly Asn Phe Asp Ile Leu Arg Asp 
            100                 105                 110         


Glu Leu Glu Val Val Leu Lys Asp Val Leu Gln Glu Pro Lys Thr Glu 
        115                 120                 125             


Asp Ile Val Ala Val Gln Lys Ala Lys Ala Leu Tyr Arg Ser Cys Ile 
    130                 135                 140                 


Asn Glu Ser Ala Ile Asp Ser Arg Gly Gly Glu Pro Leu Leu Lys Leu 
145                 150                 155                 160 


Leu Pro Asp Ile Tyr Gly Trp Pro Val Ala Thr Glu Asn Trp Glu Gln 
                165                 170                 175     


Lys Tyr Gly Ala Ser Trp Thr Ala Glu Lys Ala Ile Ala Gln Leu Asn 
            180                 185                 190         


Ser Lys Tyr Gly Lys Lys Val Leu Ile Asn Leu Phe Val Gly Thr Asp 
        195                 200                 205             


Asp Lys Asn Ser Val Asn His Val Ile His Ile Asp Gln Pro Arg Leu 
    210                 215                 220                 


Gly Leu Pro Ser Arg Asp Tyr Tyr Glu Cys Thr Gly Ile Tyr Lys Glu 
225                 230                 235                 240 


Ala Cys Thr Ala Tyr Val Asp Phe Met Ile Ser Val Ala Arg Leu Ile 
                245                 250                 255     


Arg Gln Glu Glu Arg Leu Pro Ile Asp Glu Asn Gln Leu Ala Leu Glu 
            260                 265                 270         


Met Asn Lys Val Met Glu Leu Glu Lys Glu Ile Ala Asn Ala Thr Ala 
        275                 280                 285             


Lys Pro Glu Asp Arg Asn Asp Pro Met Leu Leu Tyr Asn Lys Met Thr 
    290                 295                 300                 


Leu Ala Gln Ile Gln Asn Asn Phe Ser Leu Glu Ile Asn Gly Lys Pro 
305                 310                 315                 320 


Phe Ser Trp Leu Asn Phe Thr Asn Glu Ile Met Ser Thr Val Asn Ile 
                325                 330                 335     


Ser Ile Thr Asn Glu Glu Asp Val Val Val Tyr Ala Pro Glu Tyr Leu 
            340                 345                 350         


Thr Lys Leu Lys Pro Ile Leu Thr Lys Tyr Ser Ala Arg Asp Leu Gln 
        355                 360                 365             


Asn Leu Met Ser Trp Arg Phe Ile Met Asp Leu Val Ser Ser Leu Ser 
    370                 375                 380                 


Arg Thr Tyr Lys Glu Ser Arg Asn Ala Phe Arg Lys Ala Leu Tyr Gly 
385                 390                 395                 400 


Thr Thr Ser Glu Thr Ala Thr Trp Arg Arg Cys Ala Asn Tyr Val Asn 
                405                 410                 415     


Gly Asn Met Glu Asn Ala Val Gly Arg Leu Tyr Val Glu Ala Ala Phe 
            420                 425                 430         


Ala Gly Glu Ser Lys His Val Val Glu Asp Leu Ile Ala Gln Ile Arg 
        435                 440                 445             


Glu Val Phe Ile Gln Thr Leu Asp Asp Leu Thr Trp Met Asp Ala Glu 
    450                 455                 460                 


Thr Lys Lys Arg Ala Glu Glu Lys Ala Leu Ala Ile Lys Glu Arg Ile 
465                 470                 475                 480 


Gly Tyr Pro Asp Asp Ile Val Ser Asn Asp Asn Lys Leu Asn Asn Glu 
                485                 490                 495     


Tyr Leu Glu Leu Asn Tyr Lys Glu Asp Glu Tyr Phe Glu Asn Ile Ile 
            500                 505                 510         


Gln Asn Leu Lys Phe Ser Gln Ser Lys Gln Leu Lys Lys Leu Arg Glu 
        515                 520                 525             


Lys Val Asp Lys Asp Glu Trp Ile Ser Gly Ala Ala Val Val Asn Ala 
    530                 535                 540                 


Phe Tyr Ser Ser Gly Arg Asn Gln Ile Val Phe Pro Ala Gly Ile Leu 
545                 550                 555                 560 


Gln Pro Pro Phe Phe Ser Ala Gln Gln Ser Asn Ser Leu Asn Tyr Gly 
                565                 570                 575     


Gly Ile Gly Met Val Ile Gly His Glu Ile Thr His Gly Phe Asp Asp 
            580                 585                 590         


Asn Gly Arg Asn Phe Asn Lys Asp Gly Asp Leu Val Asp Trp Trp Thr 
        595                 600                 605             


Gln Gln Ser Ala Ser Asn Phe Lys Glu Gln Ser Gln Cys Met Val Tyr 
    610                 615                 620                 


Gln Tyr Gly Asn Phe Ser Trp Asp Leu Ala Gly Gly Gln His Leu Asn 
625                 630                 635                 640 


Gly Ile Asn Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Gly 
                645                 650                 655     


Gln Ala Tyr Arg Ala Tyr Gln Asn Tyr Ile Lys Lys Asn Gly Glu Glu 
            660                 665                 670         


Lys Leu Leu Pro Gly Leu Asp Leu Asn His Lys Gln Leu Phe Phe Leu 
        675                 680                 685             


Asn Phe Ala Gln Val Trp Cys Gly Thr Tyr Arg Pro Glu Tyr Ala Val 
    690                 695                 700                 


Asn Ser Ile Lys Thr Asp Val His Ser Pro Gly Asn Phe Arg Ile Ile 
705                 710                 715                 720 


Gly Thr Leu Gln Asn Ser Ala Glu Phe Ser Glu Ala Phe His Cys Arg 
                725                 730                 735     


Lys Asn Ser Tyr Met Asn Pro Glu Lys Lys Cys Arg Val Trp 
            740                 745                 750 


<210>  321
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  321

Met Leu Gly Asn Lys Arg Leu Gly Leu Ser Gly Leu Thr Leu Ala Leu 
1               5                   10                  15      


Ser Leu Leu Val Cys Leu Gly Ala Leu Ala Glu Ala Tyr Pro Ser Lys 
            20                  25                  30          


Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp Met Ala Arg Tyr 
        35                  40                  45              


Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr Arg Gln Arg Tyr 
    50                  55                  60                  


Gly Lys Arg Ser Ser Pro Glu Thr Leu Ile Ser Asp Leu Leu Met Arg 
65                  70                  75                  80  


Glu Ser Thr Glu Asn Val Pro Arg Thr Arg Leu Glu Asp Pro Ala Met 
                85                  90                  95      


Trp 
    


<210>  322
<211>  540
<212>  PRT
<213>  Homo sapiens

<400>  322

Met Pro Ser Leu Leu Val Leu Thr Phe Ser Pro Cys Val Leu Leu Gly 
1               5                   10                  15      


Trp Ala Leu Leu Ala Gly Gly Thr Gly Gly Gly Gly Val Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Gly Ile Gly Gly Gly Arg Gln Glu Arg Glu Ala Leu 
        35                  40                  45              


Pro Pro Gln Lys Ile Glu Val Leu Val Leu Leu Pro Gln Asp Asp Ser 
    50                  55                  60                  


Tyr Leu Phe Ser Leu Thr Arg Val Arg Pro Ala Ile Glu Tyr Ala Leu 
65                  70                  75                  80  


Arg Ser Val Glu Gly Asn Gly Thr Gly Arg Arg Leu Leu Pro Pro Gly 
                85                  90                  95      


Thr Arg Phe Gln Val Ala Tyr Glu Asp Ser Asp Cys Gly Asn Arg Ala 
            100                 105                 110         


Leu Phe Ser Leu Val Asp Arg Val Ala Ala Ala Arg Gly Ala Lys Pro 
        115                 120                 125             


Asp Leu Ile Leu Gly Pro Val Cys Glu Tyr Ala Ala Ala Pro Val Ala 
    130                 135                 140                 


Arg Leu Ala Ser His Trp Asp Leu Pro Met Leu Ser Ala Gly Ala Leu 
145                 150                 155                 160 


Ala Ala Gly Phe Gln His Lys Asp Ser Glu Tyr Ser His Leu Thr Arg 
                165                 170                 175     


Val Ala Pro Ala Tyr Ala Lys Met Gly Glu Met Met Leu Ala Leu Phe 
            180                 185                 190         


Arg His His His Trp Ser Arg Ala Ala Leu Val Tyr Ser Asp Asp Lys 
        195                 200                 205             


Leu Glu Arg Asn Cys Tyr Phe Thr Leu Glu Gly Val His Glu Val Phe 
    210                 215                 220                 


Gln Glu Glu Gly Leu His Thr Ser Ile Tyr Ser Phe Asp Glu Thr Lys 
225                 230                 235                 240 


Asp Leu Asp Leu Glu Asp Ile Val Arg Asn Ile Gln Ala Ser Glu Arg 
                245                 250                 255     


Val Val Ile Met Cys Ala Ser Ser Asp Thr Ile Arg Ser Ile Met Leu 
            260                 265                 270         


Val Ala His Arg His Gly Met Thr Ser Gly Asp Tyr Ala Phe Phe Asn 
        275                 280                 285             


Ile Glu Leu Phe Asn Ser Ser Ser Tyr Gly Asp Gly Ser Trp Lys Arg 
    290                 295                 300                 


Gly Asp Lys His Asp Phe Glu Ala Lys Gln Ala Tyr Ser Ser Leu Gln 
305                 310                 315                 320 


Thr Val Thr Leu Leu Arg Thr Val Lys Pro Glu Phe Glu Lys Phe Ser 
                325                 330                 335     


Met Glu Val Lys Ser Ser Val Glu Lys Gln Gly Leu Asn Met Glu Asp 
            340                 345                 350         


Tyr Val Asn Met Phe Val Glu Gly Phe His Asp Ala Ile Leu Leu Tyr 
        355                 360                 365             


Val Leu Ala Leu His Glu Val Leu Arg Ala Gly Tyr Ser Lys Lys Asp 
    370                 375                 380                 


Gly Gly Lys Ile Ile Gln Gln Thr Trp Asn Arg Thr Phe Glu Gly Ile 
385                 390                 395                 400 


Ala Gly Gln Val Ser Ile Asp Ala Asn Gly Asp Arg Tyr Gly Asp Phe 
                405                 410                 415     


Ser Val Ile Ala Met Thr Asp Val Glu Ala Gly Thr Gln Glu Val Ile 
            420                 425                 430         


Gly Asp Tyr Phe Gly Lys Glu Gly Arg Phe Glu Met Arg Pro Asn Val 
        435                 440                 445             


Lys Tyr Pro Trp Gly Pro Leu Lys Leu Arg Ile Asp Glu Asn Arg Ile 
    450                 455                 460                 


Val Glu His Thr Asn Ser Ser Pro Cys Lys Ser Cys Gly Leu Glu Glu 
465                 470                 475                 480 


Ser Ala Val Thr Gly Ile Val Val Gly Ala Leu Leu Gly Ala Gly Leu 
                485                 490                 495     


Leu Met Ala Phe Tyr Phe Phe Arg Lys Lys Tyr Arg Ile Thr Ile Glu 
            500                 505                 510         


Arg Arg Thr Gln Gln Glu Glu Ser Asn Leu Gly Lys His Arg Glu Leu 
        515                 520                 525             


Arg Glu Asp Ser Ile Arg Ser His Phe Ser Val Ala 
    530                 535                 540 


<210>  323
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  323

Met Asn Ser Thr Leu Phe Ser Gln Val Glu Asn His Ser Val His Ser 
1               5                   10                  15      


Asn Phe Ser Glu Lys Asn Ala Gln Leu Leu Ala Phe Glu Asn Asp Asp 
            20                  25                  30          


Cys His Leu Pro Leu Ala Met Ile Phe Thr Leu Ala Leu Ala Tyr Gly 
        35                  40                  45              


Ala Val Ile Ile Leu Gly Val Ser Gly Asn Leu Ala Leu Ile Ile Ile 
    50                  55                  60                  


Ile Leu Lys Gln Lys Glu Met Arg Asn Val Thr Asn Ile Leu Ile Val 
65                  70                  75                  80  


Asn Leu Ser Phe Ser Asp Leu Leu Val Ala Ile Met Cys Leu Pro Phe 
                85                  90                  95      


Thr Phe Val Tyr Thr Leu Met Asp His Trp Val Phe Gly Glu Ala Met 
            100                 105                 110         


Cys Lys Leu Asn Pro Phe Val Gln Cys Val Ser Ile Thr Val Ser Ile 
        115                 120                 125             


Phe Ser Leu Val Leu Ile Ala Val Glu Arg His Gln Leu Ile Ile Asn 
    130                 135                 140                 


Pro Arg Gly Trp Arg Pro Asn Asn Arg His Ala Tyr Val Gly Ile Ala 
145                 150                 155                 160 


Val Ile Trp Val Leu Ala Val Ala Ser Ser Leu Pro Phe Leu Ile Tyr 
                165                 170                 175     


Gln Val Met Thr Asp Glu Pro Phe Gln Asn Val Thr Leu Asp Ala Tyr 
            180                 185                 190         


Lys Asp Lys Tyr Val Cys Phe Asp Gln Phe Pro Ser Asp Ser His Arg 
        195                 200                 205             


Leu Ser Tyr Thr Thr Leu Leu Leu Val Leu Gln Tyr Phe Gly Pro Leu 
    210                 215                 220                 


Cys Phe Ile Phe Ile Cys Tyr Phe Lys Ile Tyr Ile Arg Leu Lys Arg 
225                 230                 235                 240 


Arg Asn Asn Met Met Asp Lys Met Arg Asp Asn Lys Tyr Arg Ser Ser 
                245                 250                 255     


Glu Thr Lys Arg Ile Asn Ile Met Leu Leu Ser Ile Val Val Ala Phe 
            260                 265                 270         


Ala Val Cys Trp Leu Pro Leu Thr Ile Phe Asn Thr Val Phe Asp Trp 
        275                 280                 285             


Asn His Gln Ile Ile Ala Thr Cys Asn His Asn Leu Leu Phe Leu Leu 
    290                 295                 300                 


Cys His Leu Thr Ala Met Ile Ser Thr Cys Val Asn Pro Ile Phe Tyr 
305                 310                 315                 320 


Gly Phe Leu Asn Lys Asn Phe Gln Arg Asp Leu Gln Phe Phe Phe Asn 
                325                 330                 335     


Phe Cys Asp Phe Arg Ser Arg Asp Asp Asp Tyr Glu Thr Ile Ala Met 
            340                 345                 350         


Ser Thr Met His Thr Asp Val Ser Lys Thr Ser Leu Lys Gln Ala Ser 
        355                 360                 365             


Pro Val Ala Phe Lys Lys Ile Asn Asn Asn Asp Asp Asn Glu Lys Ile 
    370                 375                 380                 


<210>  324
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  324

Met Glu Pro Ala Pro Ser Ala Gly Ala Glu Leu Gln Pro Pro Leu Phe 
1               5                   10                  15      


Ala Asn Ala Ser Asp Ala Tyr Pro Ser Ala Cys Pro Ser Ala Gly Ala 
            20                  25                  30          


Asn Ala Ser Gly Pro Pro Gly Ala Arg Ser Ala Ser Ser Leu Ala Leu 
        35                  40                  45              


Ala Ile Ala Ile Thr Ala Leu Tyr Ser Ala Val Cys Ala Val Gly Leu 
    50                  55                  60                  


Leu Gly Asn Val Leu Val Met Phe Gly Ile Val Arg Tyr Thr Lys Met 
65                  70                  75                  80  


Lys Thr Ala Thr Asn Ile Tyr Ile Phe Asn Leu Ala Leu Ala Asp Ala 
                85                  90                  95      


Leu Ala Thr Ser Thr Leu Pro Phe Gln Ser Ala Lys Tyr Leu Met Glu 
            100                 105                 110         


Thr Trp Pro Phe Gly Glu Leu Leu Cys Lys Ala Val Leu Ser Ile Asp 
        115                 120                 125             


Tyr Tyr Asn Met Phe Thr Ser Ile Phe Thr Leu Thr Met Met Ser Val 
    130                 135                 140                 


Asp Arg Tyr Ile Ala Val Cys His Pro Val Lys Ala Leu Asp Phe Arg 
145                 150                 155                 160 


Thr Pro Ala Lys Ala Lys Leu Ile Asn Ile Cys Ile Trp Val Leu Ala 
                165                 170                 175     


Ser Gly Val Gly Val Pro Ile Met Val Met Ala Val Thr Arg Pro Arg 
            180                 185                 190         


Asp Gly Ala Val Val Cys Met Leu Gln Phe Pro Ser Pro Ser Trp Tyr 
        195                 200                 205             


Trp Asp Thr Val Thr Lys Ile Cys Val Phe Leu Phe Ala Phe Val Val 
    210                 215                 220                 


Pro Ile Leu Ile Ile Thr Val Cys Tyr Gly Leu Met Leu Leu Arg Leu 
225                 230                 235                 240 


Arg Ser Val Arg Leu Leu Ser Gly Ser Lys Glu Lys Asp Arg Ser Leu 
                245                 250                 255     


Arg Arg Ile Thr Arg Met Val Leu Val Val Val Gly Ala Phe Val Val 
            260                 265                 270         


Cys Trp Ala Pro Ile His Ile Phe Val Ile Val Trp Thr Leu Val Asp 
        275                 280                 285             


Ile Asp Arg Arg Asp Pro Leu Val Val Ala Ala Leu His Leu Cys Ile 
    290                 295                 300                 


Ala Leu Gly Tyr Ala Asn Ser Ser Leu Asn Pro Val Leu Tyr Ala Phe 
305                 310                 315                 320 


Leu Asp Glu Asn Phe Lys Arg Cys Phe Arg Gln Leu Cys Arg Lys Pro 
                325                 330                 335     


Cys Gly Arg Pro Asp Pro Ser Ser Phe Ser Arg Ala Arg Glu Ala Thr 
            340                 345                 350         


Ala Arg Glu Arg Val Thr Ala Cys Thr Pro Ser Asp Gly Pro Gly Gly 
        355                 360                 365             


Gly Ala Ala Ala 
    370         


<210>  325
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  325

Met Asp Ser Pro Ile Gln Ile Phe Arg Gly Glu Pro Gly Pro Thr Cys 
1               5                   10                  15      


Ala Pro Ser Ala Cys Leu Pro Pro Asn Ser Ser Ala Trp Phe Pro Gly 
            20                  25                  30          


Trp Ala Glu Pro Asp Ser Asn Gly Ser Ala Gly Ser Glu Asp Ala Gln 
        35                  40                  45              


Leu Glu Pro Ala His Ile Ser Pro Ala Ile Pro Val Ile Ile Thr Ala 
    50                  55                  60                  


Val Tyr Ser Val Val Phe Val Val Gly Leu Val Gly Asn Ser Leu Val 
65                  70                  75                  80  


Met Phe Val Ile Ile Arg Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile 
                85                  90                  95      


Tyr Ile Phe Asn Leu Ala Leu Ala Asp Ala Leu Val Thr Thr Thr Met 
            100                 105                 110         


Pro Phe Gln Ser Thr Val Tyr Leu Met Asn Ser Trp Pro Phe Gly Asp 
        115                 120                 125             


Val Leu Cys Lys Ile Val Ile Ser Ile Asp Tyr Tyr Asn Met Phe Thr 
    130                 135                 140                 


Ser Ile Phe Thr Leu Thr Met Met Ser Val Asp Arg Tyr Ile Ala Val 
145                 150                 155                 160 


Cys His Pro Val Lys Ala Leu Asp Phe Arg Thr Pro Leu Lys Ala Lys 
                165                 170                 175     


Ile Ile Asn Ile Cys Ile Trp Leu Leu Ser Ser Ser Val Gly Ile Ser 
            180                 185                 190         


Ala Ile Val Leu Gly Gly Thr Lys Val Arg Glu Asp Val Asp Val Ile 
        195                 200                 205             


Glu Cys Ser Leu Gln Phe Pro Asp Asp Asp Tyr Ser Trp Trp Asp Leu 
    210                 215                 220                 


Phe Met Lys Ile Cys Val Phe Ile Phe Ala Phe Val Ile Pro Val Leu 
225                 230                 235                 240 


Ile Ile Ile Val Cys Tyr Thr Leu Met Ile Leu Arg Leu Lys Ser Val 
                245                 250                 255     


Arg Leu Leu Ser Gly Ser Arg Glu Lys Asp Arg Asn Leu Arg Arg Ile 
            260                 265                 270         


Thr Arg Leu Val Leu Val Val Val Ala Val Phe Val Val Cys Trp Thr 
        275                 280                 285             


Pro Ile His Ile Phe Ile Leu Val Glu Ala Leu Gly Ser Thr Ser His 
    290                 295                 300                 


Ser Thr Ala Ala Leu Ser Ser Tyr Tyr Phe Cys Ile Ala Leu Gly Tyr 
305                 310                 315                 320 


Thr Asn Ser Ser Leu Asn Pro Ile Leu Tyr Ala Phe Leu Asp Glu Asn 
                325                 330                 335     


Phe Lys Arg Cys Phe Arg Asp Phe Cys Phe Pro Leu Lys Met Arg Met 
            340                 345                 350         


Glu Arg Gln Ser Thr Ser Arg Val Arg Asn Thr Val Gln Asp Pro Ala 
        355                 360                 365             


Tyr Leu Arg Asp Ile Asp Gly Met Asn Lys Pro Val 
    370                 375                 380 


<210>  326
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  326

Met Glu Pro Leu Phe Pro Ala Pro Phe Trp Glu Val Ile Tyr Gly Ser 
1               5                   10                  15      


His Leu Gln Gly Asn Leu Ser Leu Leu Ser Pro Asn His Ser Leu Leu 
            20                  25                  30          


Pro Pro His Leu Leu Leu Asn Ala Ser His Gly Ala Phe Leu Pro Leu 
        35                  40                  45              


Gly Leu Lys Val Thr Ile Val Gly Leu Tyr Leu Ala Val Cys Val Gly 
    50                  55                  60                  


Gly Leu Leu Gly Asn Cys Leu Val Met Tyr Val Ile Leu Arg His Thr 
65                  70                  75                  80  


Lys Met Lys Thr Ala Thr Asn Ile Tyr Ile Phe Asn Leu Ala Leu Ala 
                85                  90                  95      


Asp Thr Leu Val Leu Leu Thr Leu Pro Phe Gln Gly Thr Asp Ile Leu 
            100                 105                 110         


Leu Gly Phe Trp Pro Phe Gly Asn Ala Leu Cys Lys Thr Val Ile Ala 
        115                 120                 125             


Ile Asp Tyr Tyr Asn Met Phe Thr Ser Thr Phe Thr Leu Thr Ala Met 
    130                 135                 140                 


Ser Val Asp Arg Tyr Val Ala Ile Cys His Pro Ile Arg Ala Leu Asp 
145                 150                 155                 160 


Val Arg Thr Ser Ser Lys Ala Gln Ala Val Asn Val Ala Ile Trp Ala 
                165                 170                 175     


Leu Ala Ser Val Val Gly Val Pro Val Ala Ile Met Gly Ser Ala Gln 
            180                 185                 190         


Val Glu Asp Glu Glu Ile Glu Cys Leu Val Glu Ile Pro Thr Pro Gln 
        195                 200                 205             


Asp Tyr Trp Gly Pro Val Phe Ala Ile Cys Ile Phe Leu Phe Ser Phe 
    210                 215                 220                 


Ile Val Pro Val Leu Val Ile Ser Val Cys Tyr Ser Leu Met Ile Arg 
225                 230                 235                 240 


Arg Leu Arg Gly Val Arg Leu Leu Ser Gly Ser Arg Glu Lys Asp Arg 
                245                 250                 255     


Asn Leu Arg Arg Ile Thr Arg Leu Val Leu Val Val Val Ala Val Phe 
            260                 265                 270         


Val Gly Cys Trp Thr Pro Val Gln Val Phe Val Leu Ala Gln Gly Leu 
        275                 280                 285             


Gly Val Gln Pro Ser Ser Glu Thr Ala Val Ala Ile Leu Arg Phe Cys 
    290                 295                 300                 


Thr Ala Leu Gly Tyr Val Asn Ser Cys Leu Asn Pro Ile Leu Tyr Ala 
305                 310                 315                 320 


Phe Leu Asp Glu Asn Phe Lys Ala Cys Phe Arg Lys Phe Cys Cys Ala 
                325                 330                 335     


Ser Ala Leu Arg Arg Asp Val Gln Val Ser Asp Arg Val Arg Ser Ile 
            340                 345                 350         


Ala Lys Asp Val Ala Leu Ala Cys Lys Thr Ser Glu Thr Val Pro Arg 
        355                 360                 365             


Pro Ala 
    370 


<210>  327
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  327

Met Asp Ser Ser Ala Ala Pro Thr Asn Ala Ser Asn Cys Thr Asp Ala 
1               5                   10                  15      


Leu Ala Tyr Ser Ser Cys Ser Pro Ala Pro Ser Pro Gly Ser Trp Val 
            20                  25                  30          


Asn Leu Ser His Leu Asp Gly Asn Leu Ser Asp Pro Cys Gly Pro Asn 
        35                  40                  45              


Arg Thr Asp Leu Gly Gly Arg Asp Ser Leu Cys Pro Pro Thr Gly Ser 
    50                  55                  60                  


Pro Ser Met Ile Thr Ala Ile Thr Ile Met Ala Leu Tyr Ser Ile Val 
65                  70                  75                  80  


Cys Val Val Gly Leu Phe Gly Asn Phe Leu Val Met Tyr Val Ile Val 
                85                  90                  95      


Arg Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile Tyr Ile Phe Asn Leu 
            100                 105                 110         


Ala Leu Ala Asp Ala Leu Ala Thr Ser Thr Leu Pro Phe Gln Ser Val 
        115                 120                 125             


Asn Tyr Leu Met Gly Thr Trp Pro Phe Gly Thr Ile Leu Cys Lys Ile 
    130                 135                 140                 


Val Ile Ser Ile Asp Tyr Tyr Asn Met Phe Thr Ser Ile Phe Thr Leu 
145                 150                 155                 160 


Cys Thr Met Ser Val Asp Arg Tyr Ile Ala Val Cys His Pro Val Lys 
                165                 170                 175     


Ala Leu Asp Phe Arg Thr Pro Arg Asn Ala Lys Ile Ile Asn Val Cys 
            180                 185                 190         


Asn Trp Ile Leu Ser Ser Ala Ile Gly Leu Pro Val Met Phe Met Ala 
        195                 200                 205             


Thr Thr Lys Tyr Arg Gln Gly Ser Ile Asp Cys Thr Leu Thr Phe Ser 
    210                 215                 220                 


His Pro Thr Trp Tyr Trp Glu Asn Leu Leu Lys Ile Cys Val Phe Ile 
225                 230                 235                 240 


Phe Ala Phe Ile Met Pro Val Leu Ile Ile Thr Val Cys Tyr Gly Leu 
                245                 250                 255     


Met Ile Leu Arg Leu Lys Ser Val Arg Met Leu Ser Gly Ser Lys Glu 
            260                 265                 270         


Lys Asp Arg Asn Leu Arg Arg Ile Thr Arg Met Val Leu Val Val Val 
        275                 280                 285             


Ala Val Phe Ile Val Cys Trp Thr Pro Ile His Ile Tyr Val Ile Ile 
    290                 295                 300                 


Lys Ala Leu Val Thr Ile Pro Glu Thr Thr Phe Gln Thr Val Ser Trp 
305                 310                 315                 320 


His Phe Cys Ile Ala Leu Gly Tyr Thr Asn Ser Cys Leu Asn Pro Val 
                325                 330                 335     


Leu Tyr Ala Phe Leu Asp Glu Asn Phe Lys Arg Cys Phe Arg Glu Phe 
            340                 345                 350         


Cys Ile Pro Thr Ser Ser Asn Ile Glu Gln Gln Asn Ser Thr Arg Ile 
        355                 360                 365             


Arg Gln Asn Thr Arg Asp His Pro Ser Thr Ala Asn Thr Val Asp Arg 
    370                 375                 380                 


Thr Asn His Gln Leu Glu Asn Leu Glu Ala Glu Thr Ala Pro Leu Pro 
385                 390                 395                 400 


<210>  328
<211>  974
<212>  PRT
<213>  Homo sapiens

<400>  328

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
            20                  25                  30          


Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
        35                  40                  45              


Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg Met Pro 
    50                  55                  60                  


Gly Val Thr Pro Lys Gln Ser Asp Thr Tyr Phe Cys Met Ser Met Arg 
65                  70                  75                  80  


Ile Pro Val Asp Glu Glu Ala Phe Val Ile Asp Phe Lys Pro Arg Ala 
                85                  90                  95      


Ser Met Asp Thr Val His His Met Leu Leu Phe Gly Cys Asn Met Pro 
            100                 105                 110         


Ser Ser Thr Gly Ser Tyr Trp Phe Cys Asp Glu Gly Thr Cys Thr Asp 
        115                 120                 125             


Lys Ala Asn Ile Leu Tyr Ala Trp Ala Arg Asn Ala Pro Pro Thr Arg 
    130                 135                 140                 


Leu Pro Lys Gly Val Gly Phe Arg Val Gly Gly Glu Thr Gly Ser Lys 
145                 150                 155                 160 


Tyr Phe Val Leu Gln Val His Tyr Gly Asp Ile Ser Ala Phe Arg Asp 
                165                 170                 175     


Asn Asn Lys Asp Cys Ser Gly Val Ser Leu His Leu Thr Arg Leu Pro 
            180                 185                 190         


Gln Pro Leu Ile Ala Gly Met Tyr Leu Met Met Ser Val Asp Thr Val 
        195                 200                 205             


Ile Pro Ala Gly Glu Lys Val Val Asn Ser Asp Ile Ser Cys His Tyr 
    210                 215                 220                 


Lys Asn Tyr Pro Met His Val Phe Ala Tyr Arg Val His Thr His His 
225                 230                 235                 240 


Leu Gly Lys Val Val Ser Gly Tyr Arg Val Arg Asn Gly Gln Trp Thr 
                245                 250                 255     


Leu Ile Gly Arg Gln Ser Pro Gln Leu Pro Gln Ala Phe Tyr Pro Val 
            260                 265                 270         


Gly His Pro Val Asp Val Ser Phe Gly Asp Leu Leu Ala Ala Arg Cys 
        275                 280                 285             


Val Phe Thr Gly Glu Gly Arg Thr Glu Ala Thr His Ile Gly Gly Thr 
    290                 295                 300                 


Ser Ser Asp Glu Met Cys Asn Leu Tyr Ile Met Tyr Tyr Met Glu Ala 
305                 310                 315                 320 


Lys His Ala Val Ser Phe Met Thr Cys Thr Gln Asn Val Ala Pro Asp 
                325                 330                 335     


Met Phe Arg Thr Ile Pro Pro Glu Ala Asn Ile Pro Ile Pro Val Lys 
            340                 345                 350         


Ser Asp Met Val Met Met His Glu His His Lys Glu Thr Glu Tyr Lys 
        355                 360                 365             


Asp Lys Ile Pro Leu Leu Gln Gln Pro Lys Arg Glu Glu Glu Glu Val 
    370                 375                 380                 


Leu Asp Gln Gly Asp Phe Tyr Ser Leu Leu Ser Lys Leu Leu Gly Glu 
385                 390                 395                 400 


Arg Glu Asp Val Val His Val His Lys Tyr Asn Pro Thr Glu Lys Ala 
                405                 410                 415     


Glu Ser Glu Ser Asp Leu Val Ala Glu Ile Ala Asn Val Val Gln Lys 
            420                 425                 430         


Lys Asp Leu Gly Arg Ser Asp Ala Arg Glu Gly Ala Glu His Glu Arg 
        435                 440                 445             


Gly Asn Ala Ile Leu Val Arg Asp Arg Ile His Lys Phe His Arg Leu 
    450                 455                 460                 


Val Ser Thr Leu Arg Pro Pro Glu Ser Arg Val Phe Ser Leu Gln Gln 
465                 470                 475                 480 


Pro Pro Pro Gly Glu Gly Thr Trp Glu Pro Glu His Thr Gly Asp Phe 
                485                 490                 495     


His Met Glu Glu Ala Leu Asp Trp Pro Gly Val Tyr Leu Leu Pro Gly 
            500                 505                 510         


Gln Val Ser Gly Val Ala Leu Asp Pro Lys Asn Asn Leu Val Ile Phe 
        515                 520                 525             


His Arg Gly Asp His Val Trp Asp Gly Asn Ser Phe Asp Ser Lys Phe 
    530                 535                 540                 


Val Tyr Gln Gln Ile Gly Leu Gly Pro Ile Glu Glu Asp Thr Ile Leu 
545                 550                 555                 560 


Val Ile Asp Pro Asn Asn Ala Ala Val Leu Gln Ser Ser Gly Lys Asn 
                565                 570                 575     


Leu Phe Tyr Leu Pro His Gly Leu Ser Ile Asp Lys Asp Gly Asn Tyr 
            580                 585                 590         


Trp Val Thr Asp Val Ala Leu His Gln Val Phe Lys Leu Asp Pro Asn 
        595                 600                 605             


Asn Lys Glu Gly Pro Val Leu Ile Leu Gly Arg Ser Met Gln Pro Gly 
    610                 615                 620                 


Ser Asp Gln Asn His Phe Cys Gln Pro Thr Asp Val Ala Val Asp Pro 
625                 630                 635                 640 


Gly Thr Gly Ala Ile Tyr Val Ser Asp Gly Tyr Cys Asn Ser Arg Ile 
                645                 650                 655     


Val Gln Phe Ser Pro Ser Gly Lys Phe Ile Thr Gln Trp Gly Glu Glu 
            660                 665                 670         


Ser Ser Gly Ser Ser Pro Leu Pro Gly Gln Phe Thr Val Pro His Ser 
        675                 680                 685             


Leu Ala Leu Val Pro Leu Leu Gly Gln Leu Cys Val Ala Asp Arg Glu 
    690                 695                 700                 


Asn Gly Arg Ile Gln Cys Phe Lys Thr Asp Thr Lys Glu Phe Val Arg 
705                 710                 715                 720 


Glu Ile Lys His Ser Ser Phe Gly Arg Asn Val Phe Ala Ile Ser Tyr 
                725                 730                 735     


Ile Pro Gly Leu Leu Phe Ala Val Asn Gly Lys Pro His Phe Gly Asp 
            740                 745                 750         


Gln Glu Pro Val Gln Gly Phe Val Met Asn Phe Ser Asn Gly Glu Ile 
        755                 760                 765             


Ile Asp Ile Phe Lys Pro Val Arg Lys His Phe Asp Met Pro His Asp 
    770                 775                 780                 


Ile Val Ala Ser Glu Asp Gly Thr Val Tyr Ile Gly Asp Ala His Thr 
785                 790                 795                 800 


Asn Thr Val Trp Lys Phe Thr Leu Thr Glu Lys Leu Glu His Arg Ser 
                805                 810                 815     


Val Lys Lys Ala Gly Ile Glu Val Gln Glu Ile Lys Glu Ala Glu Ala 
            820                 825                 830         


Val Val Glu Thr Lys Met Glu Asn Lys Pro Thr Ser Ser Glu Leu Gln 
        835                 840                 845             


Lys Met Gln Glu Lys Gln Lys Leu Ile Lys Glu Pro Gly Ser Gly Val 
    850                 855                 860                 


Pro Val Val Leu Ile Thr Thr Leu Leu Val Ile Pro Val Val Val Leu 
865                 870                 875                 880 


Leu Ala Ile Ala Ile Phe Ile Arg Trp Lys Lys Ser Arg Ala Phe Gly 
                885                 890                 895     


Ala Asp Ser Glu His Lys Leu Glu Thr Ser Ser Gly Arg Val Leu Gly 
            900                 905                 910         


Arg Phe Arg Gly Lys Gly Ser Gly Gly Leu Asn Leu Gly Asn Phe Phe 
        915                 920                 925             


Ala Ser Arg Lys Gly Tyr Ser Arg Lys Gly Phe Asp Arg Leu Ser Thr 
    930                 935                 940                 


Glu Gly Ser Asp Gln Glu Lys Glu Asp Asp Gly Ser Glu Ser Glu Glu 
945                 950                 955                 960 


Glu Tyr Ser Ala Pro Leu Pro Ala Leu Ala Pro Ser Ser Ser 
                965                 970                 


<210>  329
<211>  1141
<212>  PRT
<213>  Homo sapiens

<400>  329

Met Ala Val Pro Gly Asp Ala Ala Arg Val Arg Asp Lys Pro Val His 
1               5                   10                  15      


Ser Gly Val Ser Gln Ala Pro Thr Ala Gly Arg Asp Cys His His Arg 
            20                  25                  30          


Ala Asp Pro Ala Ser Pro Arg Asp Ser Gly Cys Arg Gly Cys Trp Gly 
        35                  40                  45              


Asp Leu Val Leu Gln Pro Leu Arg Ser Ser Arg Lys Leu Ser Ser Ala 
    50                  55                  60                  


Leu Cys Ala Gly Ser Leu Ser Phe Leu Leu Ala Leu Leu Val Arg Leu 
65                  70                  75                  80  


Val Arg Gly Glu Val Gly Cys Asp Leu Glu Gln Cys Lys Glu Ala Ala 
                85                  90                  95      


Ala Ala Glu Glu Glu Glu Ala Ala Pro Gly Ala Glu Gly Gly Val Phe 
            100                 105                 110         


Pro Gly Pro Arg Gly Gly Ala Pro Gly Gly Gly Ala Arg Leu Ser Pro 
        115                 120                 125             


Trp Leu Gln Pro Ser Ala Leu Leu Phe Ser Leu Leu Cys Ala Phe Phe 
    130                 135                 140                 


Trp Met Gly Leu Tyr Leu Leu Arg Ala Gly Val Arg Leu Pro Leu Ala 
145                 150                 155                 160 


Val Ala Leu Leu Ala Ala Cys Cys Gly Gly Glu Ala Leu Val Gln Ile 
                165                 170                 175     


Gly Leu Gly Val Gly Glu Asp His Leu Leu Ser Leu Pro Ala Ala Gly 
            180                 185                 190         


Val Val Leu Ser Cys Leu Ala Ala Ala Thr Trp Leu Val Leu Arg Leu 
        195                 200                 205             


Arg Leu Gly Val Leu Met Ile Ala Leu Thr Ser Ala Val Arg Thr Val 
    210                 215                 220                 


Ser Leu Ile Ser Leu Glu Arg Phe Lys Val Ala Trp Arg Pro Tyr Leu 
225                 230                 235                 240 


Ala Tyr Leu Ala Gly Val Leu Gly Ile Leu Leu Ala Arg Tyr Val Glu 
                245                 250                 255     


Gln Ile Leu Pro Gln Ser Ala Glu Ala Ala Pro Arg Glu His Leu Gly 
            260                 265                 270         


Ser Gln Leu Ile Ala Gly Thr Lys Glu Asp Ile Pro Val Phe Lys Arg 
        275                 280                 285             


Arg Arg Arg Ser Ser Ser Val Val Ser Ala Glu Met Ser Gly Cys Ser 
    290                 295                 300                 


Ser Lys Ser His Arg Arg Thr Ser Leu Pro Cys Ile Pro Arg Glu Gln 
305                 310                 315                 320 


Leu Met Gly His Ser Glu Trp Asp His Lys Arg Gly Pro Arg Gly Ser 
                325                 330                 335     


Gln Ser Ser Gly Thr Ser Ile Thr Val Asp Ile Ala Val Met Gly Glu 
            340                 345                 350         


Ala His Gly Leu Ile Thr Asp Leu Leu Ala Asp Pro Ser Leu Pro Pro 
        355                 360                 365             


Asn Val Cys Thr Ser Leu Arg Ala Val Ser Asn Leu Leu Ser Thr Gln 
    370                 375                 380                 


Leu Thr Phe Gln Ala Ile His Lys Pro Arg Val Asn Pro Val Thr Ser 
385                 390                 395                 400 


Leu Ser Glu Asn Tyr Thr Cys Ser Asp Ser Glu Glu Ser Ser Glu Lys 
                405                 410                 415     


Asp Lys Leu Ala Ile Pro Lys Arg Leu Arg Arg Ser Leu Pro Pro Gly 
            420                 425                 430         


Leu Leu Arg Arg Val Ser Ser Thr Trp Thr Thr Thr Thr Ser Ala Thr 
        435                 440                 445             


Gly Leu Pro Thr Leu Glu Pro Ala Pro Val Arg Arg Asp Arg Ser Thr 
    450                 455                 460                 


Ser Ile Lys Leu Gln Glu Ala Pro Ser Ser Ser Pro Asp Ser Trp Asn 
465                 470                 475                 480 


Asn Pro Val Met Met Thr Leu Thr Lys Ser Arg Ser Phe Thr Ser Ser 
                485                 490                 495     


Tyr Ala Ile Ser Ala Ala Asn His Val Lys Ala Lys Lys Gln Ser Arg 
            500                 505                 510         


Pro Gly Ala Leu Ala Lys Ile Ser Pro Leu Ser Ser Pro Cys Ser Ser 
        515                 520                 525             


Pro Leu Gln Gly Thr Pro Ala Ser Ser Leu Val Ser Lys Ile Ser Ala 
    530                 535                 540                 


Val Gln Phe Pro Glu Ser Ala Asp Thr Thr Ala Lys Gln Ser Leu Gly 
545                 550                 555                 560 


Ser His Arg Ala Leu Thr Tyr Thr Gln Ser Ala Pro Asp Leu Ser Pro 
                565                 570                 575     


Gln Ile Leu Thr Pro Pro Val Ile Cys Ser Ser Cys Gly Arg Pro Tyr 
            580                 585                 590         


Ser Gln Gly Asn Pro Ala Asp Glu Pro Leu Glu Arg Ser Gly Val Ala 
        595                 600                 605             


Thr Arg Thr Pro Ser Arg Thr Asp Asp Thr Ala Gln Val Thr Ser Asp 
    610                 615                 620                 


Tyr Glu Thr Asn Asn Asn Ser Asp Ser Ser Asp Ile Val Gln Asn Glu 
625                 630                 635                 640 


Asp Glu Thr Glu Cys Leu Arg Glu Pro Leu Arg Lys Ala Ser Ala Cys 
                645                 650                 655     


Ser Thr Tyr Ala Pro Glu Thr Met Met Phe Leu Asp Lys Pro Ile Leu 
            660                 665                 670         


Ala Pro Glu Pro Leu Val Met Asp Asn Leu Asp Ser Ile Met Glu Gln 
        675                 680                 685             


Leu Asn Thr Trp Asn Phe Pro Ile Phe Asp Leu Val Glu Asn Ile Gly 
    690                 695                 700                 


Arg Lys Cys Gly Arg Ile Leu Ser Gln Val Ser Tyr Arg Leu Phe Glu 
705                 710                 715                 720 


Asp Met Gly Leu Phe Glu Ala Phe Lys Ile Pro Ile Arg Glu Phe Met 
                725                 730                 735     


Asn Tyr Phe His Ala Leu Glu Ile Gly Tyr Arg Asp Ile Pro Tyr His 
            740                 745                 750         


Asn Arg Ile His Ala Thr Asp Val Leu His Ala Val Trp Tyr Leu Thr 
        755                 760                 765             


Thr Gln Pro Ile Pro Gly Leu Ser Thr Val Ile Asn Asp His Gly Ser 
    770                 775                 780                 


Thr Ser Asp Ser Asp Ser Asp Ser Gly Phe Thr His Gly His Met Gly 
785                 790                 795                 800 


Tyr Val Phe Ser Lys Thr Tyr Asn Val Thr Asp Asp Lys Tyr Gly Cys 
                805                 810                 815     


Leu Ser Gly Asn Ile Pro Ala Leu Glu Leu Met Ala Leu Tyr Val Ala 
            820                 825                 830         


Ala Ala Met His Asp Tyr Asp His Pro Gly Arg Thr Asn Ala Phe Leu 
        835                 840                 845             


Val Ala Thr Ser Ala Pro Gln Ala Val Leu Tyr Asn Asp Arg Ser Val 
    850                 855                 860                 


Leu Glu Asn His His Ala Ala Ala Ala Trp Asn Leu Phe Met Ser Arg 
865                 870                 875                 880 


Pro Glu Tyr Asn Phe Leu Ile Asn Leu Asp His Val Glu Phe Lys His 
                885                 890                 895     


Phe Arg Phe Leu Val Ile Glu Ala Ile Leu Ala Thr Asp Leu Lys Lys 
            900                 905                 910         


His Phe Asp Phe Val Ala Lys Phe Asn Gly Lys Val Asn Asp Asp Val 
        915                 920                 925             


Gly Ile Asp Trp Thr Asn Glu Asn Asp Arg Leu Leu Val Cys Gln Met 
    930                 935                 940                 


Cys Ile Lys Leu Ala Asp Ile Asn Gly Pro Ala Lys Cys Lys Glu Leu 
945                 950                 955                 960 


His Leu Gln Trp Thr Asp Gly Ile Val Asn Glu Phe Tyr Glu Gln Gly 
                965                 970                 975     


Asp Glu Glu Ala Ser Leu Gly Leu Pro Ile Ser Pro Phe Met Asp Arg 
            980                 985                 990         


Ser Ala Pro Gln Leu Ala Asn Leu  Gln Glu Ser Phe Ile  Ser His Ile 
        995                 1000                 1005             


Val Gly  Pro Leu Cys Asn Ser  Tyr Asp Ser Ala Gly  Leu Met Pro 
    1010                 1015                 1020             


Gly Lys  Trp Val Glu Asp Ser  Asp Glu Ser Gly Asp  Thr Asp Asp 
    1025                 1030                 1035             


Pro Glu  Glu Glu Glu Glu Glu  Ala Pro Ala Pro Asn  Glu Glu Glu 
    1040                 1045                 1050             


Thr Cys  Glu Asn Asn Glu Ser  Pro Lys Lys Lys Thr  Phe Lys Arg 
    1055                 1060                 1065             


Arg Lys  Ile Tyr Cys Gln Ile  Thr Gln His Leu Leu  Gln Asn His 
    1070                 1075                 1080             


Lys Met  Trp Lys Lys Val Ile  Glu Glu Glu Gln Arg  Leu Ala Gly 
    1085                 1090                 1095             


Ile Glu  Asn Gln Ser Leu Asp  Gln Thr Pro Gln Ser  His Ser Ser 
    1100                 1105                 1110             


Glu Gln  Ile Gln Ala Ile Lys  Glu Glu Glu Glu Glu  Lys Gly Lys 
    1115                 1120                 1125             


Pro Arg  Gly Glu Glu Ile Pro  Thr Gln Lys Pro Asp  Gln 
    1130                 1135                 1140     


<210>  330
<211>  1112
<212>  PRT
<213>  Homo sapiens

<400>  330

Met Arg Arg Asp Glu Arg Asp Ala Lys Ala Met Arg Ser Leu Gln Pro 
1               5                   10                  15      


Pro Asp Gly Ala Gly Ser Pro Pro Glu Ser Leu Arg Asn Gly Tyr Val 
            20                  25                  30          


Lys Ser Cys Val Ser Pro Leu Arg Gln Asp Pro Pro Arg Gly Phe Phe 
        35                  40                  45              


Phe His Leu Cys Arg Phe Cys Asn Val Glu Leu Arg Pro Pro Pro Ala 
    50                  55                  60                  


Ser Pro Gln Gln Pro Arg Arg Cys Ser Pro Phe Cys Arg Ala Arg Leu 
65                  70                  75                  80  


Ser Leu Gly Ala Leu Ala Ala Phe Val Leu Ala Leu Leu Leu Gly Ala 
                85                  90                  95      


Glu Pro Glu Ser Trp Ala Ala Gly Ala Ala Trp Leu Arg Thr Leu Leu 
            100                 105                 110         


Ser Val Cys Ser His Ser Leu Ser Pro Leu Phe Ser Ile Ala Cys Ala 
        115                 120                 125             


Phe Phe Phe Leu Thr Cys Phe Leu Thr Arg Thr Lys Arg Gly Pro Gly 
    130                 135                 140                 


Pro Gly Arg Ser Cys Gly Ser Trp Trp Leu Leu Ala Leu Pro Ala Cys 
145                 150                 155                 160 


Cys Tyr Leu Gly Asp Phe Leu Val Trp Gln Trp Trp Ser Trp Pro Trp 
                165                 170                 175     


Gly Asp Gly Asp Ala Gly Ser Ala Ala Pro His Thr Pro Pro Glu Ala 
            180                 185                 190         


Ala Ala Gly Arg Leu Leu Leu Val Leu Ser Cys Val Gly Leu Leu Leu 
        195                 200                 205             


Thr Leu Ala His Pro Leu Arg Leu Arg His Cys Val Leu Val Leu Leu 
    210                 215                 220                 


Leu Ala Ser Phe Val Trp Trp Val Ser Phe Thr Ser Leu Gly Ser Leu 
225                 230                 235                 240 


Pro Ser Ala Leu Arg Pro Leu Leu Ser Gly Leu Val Gly Gly Ala Gly 
                245                 250                 255     


Cys Leu Leu Ala Leu Gly Leu Asp His Phe Phe Gln Ile Arg Glu Ala 
            260                 265                 270         


Pro Leu His Pro Arg Leu Ser Ser Ala Ala Glu Glu Lys Val Pro Val 
        275                 280                 285             


Ile Arg Pro Arg Arg Arg Ser Ser Cys Val Ser Leu Gly Glu Thr Ala 
    290                 295                 300                 


Ala Ser Tyr Tyr Gly Ser Cys Lys Ile Phe Arg Arg Pro Ser Leu Pro 
305                 310                 315                 320 


Cys Ile Ser Arg Glu Gln Met Ile Leu Trp Asp Trp Asp Leu Lys Gln 
                325                 330                 335     


Trp Tyr Lys Pro His Tyr Gln Asn Ser Gly Gly Gly Asn Gly Val Asp 
            340                 345                 350         


Leu Ser Val Leu Asn Glu Ala Arg Asn Met Val Ser Asp Leu Leu Thr 
        355                 360                 365             


Asp Pro Ser Leu Pro Pro Gln Val Ile Ser Ser Leu Arg Ser Ile Ser 
    370                 375                 380                 


Ser Leu Met Gly Ala Phe Ser Gly Ser Cys Arg Pro Lys Ile Asn Pro 
385                 390                 395                 400 


Leu Thr Pro Phe Pro Gly Phe Tyr Pro Cys Ser Glu Ile Glu Asp Pro 
                405                 410                 415     


Ala Glu Lys Gly Asp Arg Lys Leu Asn Lys Gly Leu Asn Arg Asn Ser 
            420                 425                 430         


Leu Pro Thr Pro Gln Leu Arg Arg Ser Ser Gly Thr Ser Gly Leu Leu 
        435                 440                 445             


Pro Val Glu Gln Ser Ser Arg Trp Asp Arg Asn Asn Gly Lys Arg Pro 
    450                 455                 460                 


His Gln Glu Phe Gly Ile Ser Ser Gln Gly Cys Tyr Leu Asn Gly Pro 
465                 470                 475                 480 


Phe Asn Ser Asn Leu Leu Thr Ile Pro Lys Gln Arg Ser Ser Ser Val 
                485                 490                 495     


Ser Leu Thr His His Val Gly Leu Arg Arg Ala Gly Val Leu Ser Ser 
            500                 505                 510         


Leu Ser Pro Val Asn Ser Ser Asn His Gly Pro Val Ser Thr Gly Ser 
        515                 520                 525             


Leu Thr Asn Arg Ser Pro Ile Glu Phe Pro Asp Thr Ala Asp Phe Leu 
    530                 535                 540                 


Asn Lys Pro Ser Val Ile Leu Gln Arg Ser Leu Gly Asn Ala Pro Asn 
545                 550                 555                 560 


Thr Pro Asp Phe Tyr Gln Gln Leu Arg Asn Ser Asp Ser Asn Leu Cys 
                565                 570                 575     


Asn Ser Cys Gly His Gln Met Leu Lys Tyr Val Ser Thr Ser Glu Ser 
            580                 585                 590         


Asp Gly Thr Asp Cys Cys Ser Gly Lys Ser Gly Glu Glu Glu Asn Ile 
        595                 600                 605             


Phe Ser Lys Glu Ser Phe Lys Leu Met Glu Thr Gln Gln Glu Glu Glu 
    610                 615                 620                 


Thr Glu Lys Lys Asp Ser Arg Lys Leu Phe Gln Glu Gly Asp Lys Trp 
625                 630                 635                 640 


Leu Thr Glu Glu Ala Gln Ser Glu Gln Gln Thr Asn Ile Glu Gln Glu 
                645                 650                 655     


Val Ser Leu Asp Leu Ile Leu Val Glu Glu Tyr Asp Ser Leu Ile Glu 
            660                 665                 670         


Lys Met Ser Asn Trp Asn Phe Pro Ile Phe Glu Leu Val Glu Lys Met 
        675                 680                 685             


Gly Glu Lys Ser Gly Arg Ile Leu Ser Gln Val Met Tyr Thr Leu Phe 
    690                 695                 700                 


Gln Asp Thr Gly Leu Leu Glu Ile Phe Lys Ile Pro Thr Gln Gln Phe 
705                 710                 715                 720 


Met Asn Tyr Phe Arg Ala Leu Glu Asn Gly Tyr Arg Asp Ile Pro Tyr 
                725                 730                 735     


His Asn Arg Ile His Ala Thr Asp Val Leu His Ala Val Trp Tyr Leu 
            740                 745                 750         


Thr Thr Arg Pro Val Pro Gly Leu Gln Gln Ile His Asn Gly Cys Gly 
        755                 760                 765             


Thr Gly Asn Glu Thr Asp Ser Asp Gly Arg Ile Asn His Gly Arg Ile 
    770                 775                 780                 


Ala Tyr Ile Ser Ser Lys Ser Cys Ser Asn Pro Asp Glu Ser Tyr Gly 
785                 790                 795                 800 


Cys Leu Ser Ser Asn Ile Pro Ala Leu Glu Leu Met Ala Leu Tyr Val 
                805                 810                 815     


Ala Ala Ala Met His Asp Tyr Asp His Pro Gly Arg Thr Asn Ala Phe 
            820                 825                 830         


Leu Val Ala Thr Asn Ala Pro Gln Ala Val Leu Tyr Asn Asp Arg Ser 
        835                 840                 845             


Val Leu Glu Asn His His Ala Ala Ser Ala Trp Asn Leu Tyr Leu Ser 
    850                 855                 860                 


Arg Pro Glu Tyr Asn Phe Leu Leu His Leu Asp His Val Glu Phe Lys 
865                 870                 875                 880 


Arg Phe Arg Phe Leu Val Ile Glu Ala Ile Leu Ala Thr Asp Leu Lys 
                885                 890                 895     


Lys His Phe Asp Phe Leu Ala Glu Phe Asn Ala Lys Ala Asn Asp Val 
            900                 905                 910         


Asn Ser Asn Gly Ile Glu Trp Ser Asn Glu Asn Asp Arg Leu Leu Val 
        915                 920                 925             


Cys Gln Val Cys Ile Lys Leu Ala Asp Ile Asn Gly Pro Ala Lys Val 
    930                 935                 940                 


Arg Asp Leu His Leu Lys Trp Thr Glu Gly Ile Val Asn Glu Phe Tyr 
945                 950                 955                 960 


Glu Gln Gly Asp Glu Glu Ala Asn Leu Gly Leu Pro Ile Ser Pro Phe 
                965                 970                 975     


Met Asp Arg Ser Ser Pro Gln Leu Ala Lys Leu Gln Glu Ser Phe Ile 
            980                 985                 990         


Thr His Ile Val Gly Pro Leu Cys  Asn Ser Tyr Asp Ala  Ala Gly Leu 
        995                 1000                 1005             


Leu Pro  Gly Gln Trp Leu Glu  Ala Glu Glu Asp Asn  Asp Thr Glu 
    1010                 1015                 1020             


Ser Gly  Asp Asp Glu Asp Gly  Glu Glu Leu Asp Thr  Glu Asp Glu 
    1025                 1030                 1035             


Glu Met  Glu Asn Asn Leu Asn  Pro Lys Pro Pro Arg  Arg Lys Ser 
    1040                 1045                 1050             


Arg Arg  Arg Ile Phe Cys Gln  Leu Met His His Leu  Thr Glu Asn 
    1055                 1060                 1065             


His Lys  Ile Trp Lys Glu Ile  Val Glu Glu Glu Glu  Lys Cys Lys 
    1070                 1075                 1080             


Ala Asp  Gly Asn Lys Leu Gln  Val Glu Asn Ser Ser  Leu Pro Gln 
    1085                 1090                 1095             


Ala Asp  Glu Ile Gln Val Ile  Glu Glu Ala Asp Glu  Glu Glu 
    1100                 1105                 1110         


<210>  331
<211>  1280
<212>  PRT
<213>  Homo sapiens

<400>  331

Met Asp Leu Glu Gly Asp Arg Asn Gly Gly Ala Lys Lys Lys Asn Phe 
1               5                   10                  15      


Phe Lys Leu Asn Asn Lys Ser Glu Lys Asp Lys Lys Glu Lys Lys Pro 
            20                  25                  30          


Thr Val Ser Val Phe Ser Met Phe Arg Tyr Ser Asn Trp Leu Asp Lys 
        35                  40                  45              


Leu Tyr Met Val Val Gly Thr Leu Ala Ala Ile Ile His Gly Ala Gly 
    50                  55                  60                  


Leu Pro Leu Met Met Leu Val Phe Gly Glu Met Thr Asp Ile Phe Ala 
65                  70                  75                  80  


Asn Ala Gly Asn Leu Glu Asp Leu Met Ser Asn Ile Thr Asn Arg Ser 
                85                  90                  95      


Asp Ile Asn Asp Thr Gly Phe Phe Met Asn Leu Glu Glu Asp Met Thr 
            100                 105                 110         


Arg Tyr Ala Tyr Tyr Tyr Ser Gly Ile Gly Ala Gly Val Leu Val Ala 
        115                 120                 125             


Ala Tyr Ile Gln Val Ser Phe Trp Cys Leu Ala Ala Gly Arg Gln Ile 
    130                 135                 140                 


His Lys Ile Arg Lys Gln Phe Phe His Ala Ile Met Arg Gln Glu Ile 
145                 150                 155                 160 


Gly Trp Phe Asp Val His Asp Val Gly Glu Leu Asn Thr Arg Leu Thr 
                165                 170                 175     


Asp Asp Val Ser Lys Ile Asn Glu Gly Ile Gly Asp Lys Ile Gly Met 
            180                 185                 190         


Phe Phe Gln Ser Met Ala Thr Phe Phe Thr Gly Phe Ile Val Gly Phe 
        195                 200                 205             


Thr Arg Gly Trp Lys Leu Thr Leu Val Ile Leu Ala Ile Ser Pro Val 
    210                 215                 220                 


Leu Gly Leu Ser Ala Ala Val Trp Ala Lys Ile Leu Ser Ser Phe Thr 
225                 230                 235                 240 


Asp Lys Glu Leu Leu Ala Tyr Ala Lys Ala Gly Ala Val Ala Glu Glu 
                245                 250                 255     


Val Leu Ala Ala Ile Arg Thr Val Ile Ala Phe Gly Gly Gln Lys Lys 
            260                 265                 270         


Glu Leu Glu Arg Tyr Asn Lys Asn Leu Glu Glu Ala Lys Arg Ile Gly 
        275                 280                 285             


Ile Lys Lys Ala Ile Thr Ala Asn Ile Ser Ile Gly Ala Ala Phe Leu 
    290                 295                 300                 


Leu Ile Tyr Ala Ser Tyr Ala Leu Ala Phe Trp Tyr Gly Thr Thr Leu 
305                 310                 315                 320 


Val Leu Ser Gly Glu Tyr Ser Ile Gly Gln Val Leu Thr Val Phe Phe 
                325                 330                 335     


Ser Val Leu Ile Gly Ala Phe Ser Val Gly Gln Ala Ser Pro Ser Ile 
            340                 345                 350         


Glu Ala Phe Ala Asn Ala Arg Gly Ala Ala Tyr Glu Ile Phe Lys Ile 
        355                 360                 365             


Ile Asp Asn Lys Pro Ser Ile Asp Ser Tyr Ser Lys Ser Gly His Lys 
    370                 375                 380                 


Pro Asp Asn Ile Lys Gly Asn Leu Glu Phe Arg Asn Val His Phe Ser 
385                 390                 395                 400 


Tyr Pro Ser Arg Lys Glu Val Lys Ile Leu Lys Gly Leu Asn Leu Lys 
                405                 410                 415     


Val Gln Ser Gly Gln Thr Val Ala Leu Val Gly Asn Ser Gly Cys Gly 
            420                 425                 430         


Lys Ser Thr Thr Val Gln Leu Met Gln Arg Leu Tyr Asp Pro Thr Glu 
        435                 440                 445             


Gly Met Val Ser Val Asp Gly Gln Asp Ile Arg Thr Ile Asn Val Arg 
    450                 455                 460                 


Phe Leu Arg Glu Ile Ile Gly Val Val Ser Gln Glu Pro Val Leu Phe 
465                 470                 475                 480 


Ala Thr Thr Ile Ala Glu Asn Ile Arg Tyr Gly Arg Glu Asn Val Thr 
                485                 490                 495     


Met Asp Glu Ile Glu Lys Ala Val Lys Glu Ala Asn Ala Tyr Asp Phe 
            500                 505                 510         


Ile Met Lys Leu Pro His Lys Phe Asp Thr Leu Val Gly Glu Arg Gly 
        515                 520                 525             


Ala Gln Leu Ser Gly Gly Gln Lys Gln Arg Ile Ala Ile Ala Arg Ala 
    530                 535                 540                 


Leu Val Arg Asn Pro Lys Ile Leu Leu Leu Asp Glu Ala Thr Ser Ala 
545                 550                 555                 560 


Leu Asp Thr Glu Ser Glu Ala Val Val Gln Val Ala Leu Asp Lys Ala 
                565                 570                 575     


Arg Lys Gly Arg Thr Thr Ile Val Ile Ala His Arg Leu Ser Thr Val 
            580                 585                 590         


Arg Asn Ala Asp Val Ile Ala Gly Phe Asp Asp Gly Val Ile Val Glu 
        595                 600                 605             


Lys Gly Asn His Asp Glu Leu Met Lys Glu Lys Gly Ile Tyr Phe Lys 
    610                 615                 620                 


Leu Val Thr Met Gln Thr Ala Gly Asn Glu Val Glu Leu Glu Asn Ala 
625                 630                 635                 640 


Ala Asp Glu Ser Lys Ser Glu Ile Asp Ala Leu Glu Met Ser Ser Asn 
                645                 650                 655     


Asp Ser Arg Ser Ser Leu Ile Arg Lys Arg Ser Thr Arg Arg Ser Val 
            660                 665                 670         


Arg Gly Ser Gln Ala Gln Asp Arg Lys Leu Ser Thr Lys Glu Ala Leu 
        675                 680                 685             


Asp Glu Ser Ile Pro Pro Val Ser Phe Trp Arg Ile Met Lys Leu Asn 
    690                 695                 700                 


Leu Thr Glu Trp Pro Tyr Phe Val Val Gly Val Phe Cys Ala Ile Ile 
705                 710                 715                 720 


Asn Gly Gly Leu Gln Pro Ala Phe Ala Ile Ile Phe Ser Lys Ile Ile 
                725                 730                 735     


Gly Val Phe Thr Arg Ile Asp Asp Pro Glu Thr Lys Arg Gln Asn Ser 
            740                 745                 750         


Asn Leu Phe Ser Leu Leu Phe Leu Ala Leu Gly Ile Ile Ser Phe Ile 
        755                 760                 765             


Thr Phe Phe Leu Gln Gly Phe Thr Phe Gly Lys Ala Gly Glu Ile Leu 
    770                 775                 780                 


Thr Lys Arg Leu Arg Tyr Met Val Phe Arg Ser Met Leu Arg Gln Asp 
785                 790                 795                 800 


Val Ser Trp Phe Asp Asp Pro Lys Asn Thr Thr Gly Ala Leu Thr Thr 
                805                 810                 815     


Arg Leu Ala Asn Asp Ala Ala Gln Val Lys Gly Ala Ile Gly Ser Arg 
            820                 825                 830         


Leu Ala Val Ile Thr Gln Asn Ile Ala Asn Leu Gly Thr Gly Ile Ile 
        835                 840                 845             


Ile Ser Phe Ile Tyr Gly Trp Gln Leu Thr Leu Leu Leu Leu Ala Ile 
    850                 855                 860                 


Val Pro Ile Ile Ala Ile Ala Gly Val Val Glu Met Lys Met Leu Ser 
865                 870                 875                 880 


Gly Gln Ala Leu Lys Asp Lys Lys Glu Leu Glu Gly Ser Gly Lys Ile 
                885                 890                 895     


Ala Thr Glu Ala Ile Glu Asn Phe Arg Thr Val Val Ser Leu Thr Gln 
            900                 905                 910         


Glu Gln Lys Phe Glu His Met Tyr Ala Gln Ser Leu Gln Val Pro Tyr 
        915                 920                 925             


Arg Asn Ser Leu Arg Lys Ala His Ile Phe Gly Ile Thr Phe Ser Phe 
    930                 935                 940                 


Thr Gln Ala Met Met Tyr Phe Ser Tyr Ala Gly Cys Phe Arg Phe Gly 
945                 950                 955                 960 


Ala Tyr Leu Val Ala His Lys Leu Met Ser Phe Glu Asp Val Leu Leu 
                965                 970                 975     


Val Phe Ser Ala Val Val Phe Gly Ala Met Ala Val Gly Gln Val Ser 
            980                 985                 990         


Ser Phe Ala Pro Asp Tyr Ala Lys  Ala Lys Ile Ser Ala  Ala His Ile 
        995                 1000                 1005             


Ile Met  Ile Ile Glu Lys Thr  Pro Leu Ile Asp Ser  Tyr Ser Thr 
    1010                 1015                 1020             


Glu Gly  Leu Met Pro Asn Thr  Leu Glu Gly Asn Val  Thr Phe Gly 
    1025                 1030                 1035             


Glu Val  Val Phe Asn Tyr Pro  Thr Arg Pro Asp Ile  Pro Val Leu 
    1040                 1045                 1050             


Gln Gly  Leu Ser Leu Glu Val  Lys Lys Gly Gln Thr  Leu Ala Leu 
    1055                 1060                 1065             


Val Gly  Ser Ser Gly Cys Gly  Lys Ser Thr Val Val  Gln Leu Leu 
    1070                 1075                 1080             


Glu Arg  Phe Tyr Asp Pro Leu  Ala Gly Lys Val Leu  Leu Asp Gly 
    1085                 1090                 1095             


Lys Glu  Ile Lys Arg Leu Asn  Val Gln Trp Leu Arg  Ala His Leu 
    1100                 1105                 1110             


Gly Ile  Val Ser Gln Glu Pro  Ile Leu Phe Asp Cys  Ser Ile Ala 
    1115                 1120                 1125             


Glu Asn  Ile Ala Tyr Gly Asp  Asn Ser Arg Val Val  Ser Gln Glu 
    1130                 1135                 1140             


Glu Ile  Val Arg Ala Ala Lys  Glu Ala Asn Ile His  Ala Phe Ile 
    1145                 1150                 1155             


Glu Ser  Leu Pro Asn Lys Tyr  Ser Thr Lys Val Gly  Asp Lys Gly 
    1160                 1165                 1170             


Thr Gln  Leu Ser Gly Gly Gln  Lys Gln Arg Ile Ala  Ile Ala Arg 
    1175                 1180                 1185             


Ala Leu  Val Arg Gln Pro His  Ile Leu Leu Leu Asp  Glu Ala Thr 
    1190                 1195                 1200             


Ser Ala  Leu Asp Thr Glu Ser  Glu Lys Val Val Gln  Glu Ala Leu 
    1205                 1210                 1215             


Asp Lys  Ala Arg Glu Gly Arg  Thr Cys Ile Val Ile  Ala His Arg 
    1220                 1225                 1230             


Leu Ser  Thr Ile Gln Asn Ala  Asp Leu Ile Val Val  Phe Gln Asn 
    1235                 1240                 1245             


Gly Arg  Val Lys Glu His Gly  Thr His Gln Gln Leu  Leu Ala Gln 
    1250                 1255                 1260             


Lys Gly  Ile Tyr Phe Ser Met  Val Ser Val Gln Ala  Gly Thr Lys 
    1265                 1270                 1275             


Arg Gln  
    1280 


<210>  332
<211>  737
<212>  PRT
<213>  Homo sapiens

<400>  332

Met Gly Gly Cys Thr Val Lys Pro Gln Leu Leu Leu Leu Ala Leu Val 
1               5                   10                  15      


Leu His Pro Trp Asn Pro Cys Leu Gly Ala Asp Ser Glu Lys Pro Ser 
            20                  25                  30          


Ser Ile Pro Thr Asp Lys Leu Leu Val Ile Thr Val Ala Thr Lys Glu 
        35                  40                  45              


Ser Asp Gly Phe His Arg Phe Met Gln Ser Ala Lys Tyr Phe Asn Tyr 
    50                  55                  60                  


Thr Val Lys Val Leu Gly Gln Gly Glu Glu Trp Arg Gly Gly Asp Gly 
65                  70                  75                  80  


Ile Asn Ser Ile Gly Gly Gly Gln Lys Val Arg Leu Met Lys Glu Val 
                85                  90                  95      


Met Glu His Tyr Ala Asp Gln Asp Asp Leu Val Val Met Phe Thr Glu 
            100                 105                 110         


Cys Phe Asp Val Ile Phe Ala Gly Gly Pro Glu Glu Val Leu Lys Lys 
        115                 120                 125             


Phe Gln Lys Ala Asn His Lys Val Val Phe Ala Ala Asp Gly Ile Leu 
    130                 135                 140                 


Trp Pro Asp Lys Arg Leu Ala Asp Lys Tyr Pro Val Val His Ile Gly 
145                 150                 155                 160 


Lys Arg Tyr Leu Asn Ser Gly Gly Phe Ile Gly Tyr Ala Pro Tyr Val 
                165                 170                 175     


Asn Arg Ile Val Gln Gln Trp Asn Leu Gln Asp Asn Asp Asp Asp Gln 
            180                 185                 190         


Leu Phe Tyr Thr Lys Val Tyr Ile Asp Pro Leu Lys Arg Glu Ala Ile 
        195                 200                 205             


Asn Ile Thr Leu Asp His Lys Cys Lys Ile Phe Gln Thr Leu Asn Gly 
    210                 215                 220                 


Ala Val Asp Glu Val Val Leu Lys Phe Glu Asn Gly Lys Ala Arg Ala 
225                 230                 235                 240 


Lys Asn Thr Phe Tyr Glu Thr Leu Pro Val Ala Ile Asn Gly Asn Gly 
                245                 250                 255     


Pro Thr Lys Ile Leu Leu Asn Tyr Phe Gly Asn Tyr Val Pro Asn Ser 
            260                 265                 270         


Trp Thr Gln Asp Asn Gly Cys Thr Leu Cys Glu Phe Asp Thr Val Asp 
        275                 280                 285             


Leu Ser Ala Val Asp Val His Pro Asn Val Ser Ile Gly Val Phe Ile 
    290                 295                 300                 


Glu Gln Pro Thr Pro Phe Leu Pro Arg Phe Leu Asp Ile Leu Leu Thr 
305                 310                 315                 320 


Leu Asp Tyr Pro Lys Glu Ala Leu Lys Leu Phe Ile His Asn Lys Glu 
                325                 330                 335     


Val Tyr His Glu Lys Asp Ile Lys Val Phe Phe Asp Lys Ala Lys His 
            340                 345                 350         


Glu Ile Lys Thr Ile Lys Ile Val Gly Pro Glu Glu Asn Leu Ser Gln 
        355                 360                 365             


Ala Glu Ala Arg Asn Met Gly Met Asp Phe Cys Arg Gln Asp Glu Lys 
    370                 375                 380                 


Cys Asp Tyr Tyr Phe Ser Val Asp Ala Asp Val Val Leu Thr Asn Pro 
385                 390                 395                 400 


Arg Thr Leu Lys Ile Leu Ile Glu Gln Asn Arg Lys Ile Ile Ala Pro 
                405                 410                 415     


Leu Val Thr Arg His Gly Lys Leu Trp Ser Asn Phe Trp Gly Ala Leu 
            420                 425                 430         


Ser Pro Asp Gly Tyr Tyr Ala Arg Ser Glu Asp Tyr Val Asp Ile Val 
        435                 440                 445             


Gln Gly Asn Arg Val Gly Val Trp Asn Val Pro Tyr Met Ala Asn Val 
    450                 455                 460                 


Tyr Leu Ile Lys Gly Lys Thr Leu Arg Ser Glu Met Asn Glu Arg Asn 
465                 470                 475                 480 


Tyr Phe Val Arg Asp Lys Leu Asp Pro Asp Met Ala Leu Cys Arg Asn 
                485                 490                 495     


Ala Arg Glu Met Gly Val Phe Met Tyr Ile Ser Asn Arg His Glu Phe 
            500                 505                 510         


Gly Arg Leu Leu Ser Thr Ala Asn Tyr Asn Thr Ser His Tyr Asn Asn 
        515                 520                 525             


Asp Leu Trp Gln Ile Phe Glu Asn Pro Val Asp Trp Lys Glu Lys Tyr 
    530                 535                 540                 


Ile Asn Arg Asp Tyr Ser Lys Ile Phe Thr Glu Asn Ile Val Glu Gln 
545                 550                 555                 560 


Pro Cys Pro Asp Val Phe Trp Phe Pro Ile Phe Ser Glu Lys Ala Cys 
                565                 570                 575     


Asp Glu Leu Val Glu Glu Met Glu His Tyr Gly Lys Trp Ser Gly Gly 
            580                 585                 590         


Lys His His Asp Ser Arg Ile Ser Gly Gly Tyr Glu Asn Val Pro Thr 
        595                 600                 605             


Asp Asp Ile His Met Lys Gln Val Asp Leu Glu Asn Val Trp Leu His 
    610                 615                 620                 


Phe Ile Arg Glu Phe Ile Ala Pro Val Thr Leu Lys Val Phe Ala Gly 
625                 630                 635                 640 


Tyr Tyr Thr Lys Gly Phe Ala Leu Leu Asn Phe Val Val Lys Tyr Ser 
                645                 650                 655     


Pro Glu Arg Gln Arg Ser Leu Arg Pro His His Asp Ala Ser Thr Phe 
            660                 665                 670         


Thr Ile Asn Ile Ala Leu Asn Asn Val Gly Glu Asp Phe Gln Gly Gly 
        675                 680                 685             


Gly Cys Lys Phe Leu Arg Tyr Asn Cys Ser Ile Glu Ser Pro Arg Lys 
    690                 695                 700                 


Gly Trp Ser Phe Met His Pro Gly Arg Leu Thr His Leu His Glu Gly 
705                 710                 715                 720 


Leu Pro Val Lys Asn Gly Thr Arg Tyr Ile Ala Val Ser Phe Ile Asp 
                725                 730                 735     


Pro 
    


<210>  333
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  333

Met Gly Lys Leu Val Ala Leu Val Leu Leu Gly Val Gly Leu Ser Leu 
1               5                   10                  15      


Val Gly Glu Met Phe Leu Ala Phe Arg Glu Arg Val Asn Ala Ser Arg 
            20                  25                  30          


Glu Val Glu Pro Val Glu Pro Glu Asn Cys His Leu Ile Glu Glu Leu 
        35                  40                  45              


Glu Ser Gly Ser Glu Asp Ile Asp Ile Leu Pro Ser Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Met Pro Asn Phe Ala Pro Asp 
65                  70                  75                  80  


Glu Pro Gly Lys Ile Phe Leu Met Asp Leu Asn Glu Gln Asn Pro Arg 
                85                  90                  95      


Ala Gln Ala Leu Glu Ile Ser Gly Gly Phe Asp Lys Glu Leu Phe Asn 
            100                 105                 110         


Pro His Gly Ile Ser Ile Phe Ile Asp Lys Asp Asn Thr Val Tyr Leu 
        115                 120                 125             


Tyr Val Val Asn His Pro His Met Lys Ser Thr Val Glu Ile Phe Lys 
    130                 135                 140                 


Phe Glu Glu Gln Gln Arg Ser Leu Val Tyr Leu Lys Thr Ile Lys His 
145                 150                 155                 160 


Glu Leu Leu Lys Ser Val Asn Asp Ile Val Val Leu Gly Pro Glu Gln 
                165                 170                 175     


Phe Tyr Ala Thr Arg Asp His Tyr Phe Thr Asn Ser Leu Leu Ser Phe 
            180                 185                 190         


Phe Glu Met Ile Leu Asp Leu Arg Trp Thr Tyr Val Leu Phe Tyr Ser 
        195                 200                 205             


Pro Arg Glu Val Lys Val Val Ala Lys Gly Phe Cys Ser Ala Asn Gly 
    210                 215                 220                 


Ile Thr Val Ser Ala Asp Gln Lys Tyr Val Tyr Val Ala Asp Val Ala 
225                 230                 235                 240 


Ala Lys Asn Ile His Ile Met Glu Lys His Asp Asn Trp Asp Leu Thr 
                245                 250                 255     


Gln Leu Lys Val Ile Gln Leu Gly Thr Leu Val Asp Asn Leu Thr Val 
            260                 265                 270         


Asp Pro Ala Thr Gly Asp Ile Leu Ala Gly Cys His Pro Asn Pro Met 
        275                 280                 285             


Lys Leu Leu Asn Tyr Asn Pro Glu Asp Pro Pro Gly Ser Glu Val Leu 
    290                 295                 300                 


Arg Ile Gln Asn Val Leu Ser Glu Lys Pro Arg Val Ser Thr Val Tyr 
305                 310                 315                 320 


Ala Asn Asn Gly Ser Val Leu Gln Gly Thr Ser Val Ala Ser Val Tyr 
                325                 330                 335     


His Gly Lys Ile Leu Ile Gly Thr Val Phe His Lys Thr Leu Tyr Cys 
            340                 345                 350         


Glu Leu 
        


<210>  334
<211>  680
<212>  PRT
<213>  Homo sapiens

<400>  334

Met Ile Asn Met Gly Asp Ser His Val Asp Thr Ser Ser Thr Val Ser 
1               5                   10                  15      


Glu Ala Val Ala Glu Glu Val Ser Leu Phe Ser Met Thr Asp Met Ile 
            20                  25                  30          


Leu Phe Ser Leu Ile Val Gly Leu Leu Thr Tyr Trp Phe Leu Phe Arg 
        35                  40                  45              


Lys Lys Lys Glu Glu Val Pro Glu Phe Thr Lys Ile Gln Thr Leu Thr 
    50                  55                  60                  


Ser Ser Val Arg Glu Ser Ser Phe Val Glu Lys Met Lys Lys Thr Gly 
65                  70                  75                  80  


Arg Asn Ile Ile Val Phe Tyr Gly Ser Gln Thr Gly Thr Ala Glu Glu 
                85                  90                  95      


Phe Ala Asn Arg Leu Ser Lys Asp Ala His Arg Tyr Gly Met Arg Gly 
            100                 105                 110         


Met Ser Ala Asp Pro Glu Glu Tyr Asp Leu Ala Asp Leu Ser Ser Leu 
        115                 120                 125             


Pro Glu Ile Asp Asn Ala Leu Val Val Phe Cys Met Ala Thr Tyr Gly 
    130                 135                 140                 


Glu Gly Asp Pro Thr Asp Asn Ala Gln Asp Phe Tyr Asp Trp Leu Gln 
145                 150                 155                 160 


Glu Thr Asp Val Asp Leu Ser Gly Val Lys Phe Ala Val Phe Gly Leu 
                165                 170                 175     


Gly Asn Lys Thr Tyr Glu His Phe Asn Ala Met Gly Lys Tyr Val Asp 
            180                 185                 190         


Lys Arg Leu Glu Gln Leu Gly Ala Gln Arg Ile Phe Glu Leu Gly Leu 
        195                 200                 205             


Gly Asp Asp Asp Gly Asn Leu Glu Glu Asp Phe Ile Thr Trp Arg Glu 
    210                 215                 220                 


Gln Phe Trp Pro Ala Val Cys Glu His Phe Gly Val Glu Ala Thr Gly 
225                 230                 235                 240 


Glu Glu Ser Ser Ile Arg Gln Tyr Glu Leu Val Val His Thr Asp Ile 
                245                 250                 255     


Asp Ala Ala Lys Val Tyr Met Gly Glu Met Gly Arg Leu Lys Ser Tyr 
            260                 265                 270         


Glu Asn Gln Lys Pro Pro Phe Asp Ala Lys Asn Pro Phe Leu Ala Ala 
        275                 280                 285             


Val Thr Thr Asn Arg Lys Leu Asn Gln Gly Thr Glu Arg His Leu Met 
    290                 295                 300                 


His Leu Glu Leu Asp Ile Ser Asp Ser Lys Ile Arg Tyr Glu Ser Gly 
305                 310                 315                 320 


Asp His Val Ala Val Tyr Pro Ala Asn Asp Ser Ala Leu Val Asn Gln 
                325                 330                 335     


Leu Gly Lys Ile Leu Gly Ala Asp Leu Asp Val Val Met Ser Leu Asn 
            340                 345                 350         


Asn Leu Asp Glu Glu Ser Asn Lys Lys His Pro Phe Pro Cys Pro Thr 
        355                 360                 365             


Ser Tyr Arg Thr Ala Leu Thr Tyr Tyr Leu Asp Ile Thr Asn Pro Pro 
    370                 375                 380                 


Arg Thr Asn Val Leu Tyr Glu Leu Ala Gln Tyr Ala Ser Glu Pro Ser 
385                 390                 395                 400 


Glu Gln Glu Leu Leu Arg Lys Met Ala Ser Ser Ser Gly Glu Gly Lys 
                405                 410                 415     


Glu Leu Tyr Leu Ser Trp Val Val Glu Ala Arg Arg His Ile Leu Ala 
            420                 425                 430         


Ile Leu Gln Asp Cys Pro Ser Leu Arg Pro Pro Ile Asp His Leu Cys 
        435                 440                 445             


Glu Leu Leu Pro Arg Leu Gln Ala Arg Tyr Tyr Ser Ile Ala Ser Ser 
    450                 455                 460                 


Ser Lys Val His Pro Asn Ser Val His Ile Cys Ala Val Val Val Glu 
465                 470                 475                 480 


Tyr Glu Thr Lys Ala Gly Arg Ile Asn Lys Gly Val Ala Thr Asn Trp 
                485                 490                 495     


Leu Arg Ala Lys Glu Pro Ala Gly Glu Asn Gly Gly Arg Ala Leu Val 
            500                 505                 510         


Pro Met Phe Val Arg Lys Ser Gln Phe Arg Leu Pro Phe Lys Ala Thr 
        515                 520                 525             


Thr Pro Val Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Ile 
    530                 535                 540                 


Gly Phe Ile Gln Glu Arg Ala Trp Leu Arg Gln Gln Gly Lys Glu Val 
545                 550                 555                 560 


Gly Glu Thr Leu Leu Tyr Tyr Gly Cys Arg Arg Ser Asp Glu Asp Tyr 
                565                 570                 575     


Leu Tyr Arg Glu Glu Leu Ala Gln Phe His Arg Asp Gly Ala Leu Thr 
            580                 585                 590         


Gln Leu Asn Val Ala Phe Ser Arg Glu Gln Ser His Lys Val Tyr Val 
        595                 600                 605             


Gln His Leu Leu Lys Gln Asp Arg Glu His Leu Trp Lys Leu Ile Glu 
    610                 615                 620                 


Gly Gly Ala His Ile Tyr Val Cys Gly Asp Ala Arg Asn Met Ala Arg 
625                 630                 635                 640 


Asp Val Gln Asn Thr Phe Tyr Asp Ile Val Ala Glu Leu Gly Ala Met 
                645                 650                 655     


Glu His Ala Gln Ala Val Asp Tyr Ile Lys Lys Leu Met Thr Lys Gly 
            660                 665                 670         


Arg Tyr Ser Leu Asp Val Trp Ser 
        675                 680 


<210>  335
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  335

Met Leu Arg Leu Ser Glu Arg Asn Met Lys Val Leu Leu Ala Ala Ala 
1               5                   10                  15      


Leu Ile Ala Gly Ser Val Phe Phe Leu Leu Leu Pro Gly Pro Ser Ala 
            20                  25                  30          


Ala Asp Glu Lys Lys Lys Gly Pro Lys Val Thr Val Lys Val Tyr Phe 
        35                  40                  45              


Asp Leu Arg Ile Gly Asp Glu Asp Val Gly Arg Val Ile Phe Gly Leu 
    50                  55                  60                  


Phe Gly Lys Thr Val Pro Lys Thr Val Asp Asn Phe Val Ala Leu Ala 
65                  70                  75                  80  


Thr Gly Glu Lys Gly Phe Gly Tyr Lys Asn Ser Lys Phe His Arg Val 
                85                  90                  95      


Ile Lys Asp Phe Met Ile Gln Gly Gly Asp Phe Thr Arg Gly Asp Gly 
            100                 105                 110         


Thr Gly Gly Lys Ser Ile Tyr Gly Glu Arg Phe Pro Asp Glu Asn Phe 
        115                 120                 125             


Lys Leu Lys His Tyr Gly Pro Gly Trp Val Ser Met Ala Asn Ala Gly 
    130                 135                 140                 


Lys Asp Thr Asn Gly Ser Gln Phe Phe Ile Thr Thr Val Lys Thr Ala 
145                 150                 155                 160 


Trp Leu Asp Gly Lys His Val Val Phe Gly Lys Val Leu Glu Gly Met 
                165                 170                 175     


Glu Val Val Arg Lys Val Glu Ser Thr Lys Thr Asp Ser Arg Asp Lys 
            180                 185                 190         


Pro Leu Lys Asp Val Ile Ile Ala Asp Cys Gly Lys Ile Glu Val Glu 
        195                 200                 205             


Lys Pro Phe Ala Ile Ala Lys Glu 
    210                 215     


<210>  336
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  336

Met Gly Pro Gly Pro Arg Leu Leu Leu Pro Leu Val Leu Cys Val Gly 
1               5                   10                  15      


Leu Gly Ala Leu Val Phe Ser Ser Gly Ala Glu Gly Phe Arg Lys Arg 
            20                  25                  30          


Gly Pro Ser Val Thr Ala Lys Val Phe Phe Asp Val Arg Ile Gly Asp 
        35                  40                  45              


Lys Asp Val Gly Arg Ile Val Ile Gly Leu Phe Gly Lys Val Val Pro 
    50                  55                  60                  


Lys Thr Val Glu Asn Phe Val Ala Leu Ala Thr Gly Glu Lys Gly Tyr 
65                  70                  75                  80  


Gly Tyr Lys Gly Ser Lys Phe His Arg Val Ile Lys Asp Phe Met Ile 
                85                  90                  95      


Gln Gly Gly Asp Ile Thr Thr Gly Asp Gly Thr Gly Gly Val Ser Ile 
            100                 105                 110         


Tyr Gly Glu Thr Phe Pro Asp Glu Asn Phe Lys Leu Lys His Tyr Gly 
        115                 120                 125             


Ile Gly Trp Val Ser Met Ala Asn Ala Gly Pro Asp Thr Asn Gly Ser 
    130                 135                 140                 


Gln Phe Phe Ile Thr Leu Thr Lys Pro Thr Trp Leu Asp Gly Lys His 
145                 150                 155                 160 


Val Val Phe Gly Lys Val Ile Asp Gly Met Thr Val Val His Ser Ile 
                165                 170                 175     


Glu Leu Gln Ala Thr Asp Gly His Asp Arg Pro Leu Thr Asn Cys Ser 
            180                 185                 190         


Ile Ile Asn Ser Gly Lys Ile Asp Val Lys Thr Pro Phe Val Val Glu 
        195                 200                 205             


Ile Ala Asp Trp 
    210         


<210>  337
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  337

Met Lys Glu Asn Val Ala Ser Ala Thr Val Phe Thr Leu Leu Leu Phe 
1               5                   10                  15      


Leu Asn Thr Cys Leu Leu Asn Gly Gln Leu Pro Pro Gly Lys Pro Glu 
            20                  25                  30          


Ile Phe Lys Cys Arg Ser Pro Asn Lys Glu Thr Phe Thr Cys Trp Trp 
        35                  40                  45              


Arg Pro Gly Thr Asp Gly Gly Leu Pro Thr Asn Tyr Ser Leu Thr Tyr 
    50                  55                  60                  


His Arg Glu Gly Glu Thr Leu Met His Glu Cys Pro Asp Tyr Ile Thr 
65                  70                  75                  80  


Gly Gly Pro Asn Ser Cys His Phe Gly Lys Gln Tyr Thr Ser Met Trp 
                85                  90                  95      


Arg Thr Tyr Ile Met Met Val Asn Ala Thr Asn Gln Met Gly Ser Ser 
            100                 105                 110         


Phe Ser Asp Glu Leu Tyr Val Asp Val Thr Tyr Ile Val Gln Pro Asp 
        115                 120                 125             


Pro Pro Leu Glu Leu Ala Val Glu Val Lys Gln Pro Glu Asp Arg Lys 
    130                 135                 140                 


Pro Tyr Leu Trp Ile Lys Trp Ser Pro Pro Thr Leu Ile Asp Leu Lys 
145                 150                 155                 160 


Thr Gly Trp Phe Thr Leu Leu Tyr Glu Ile Arg Leu Lys Pro Glu Lys 
                165                 170                 175     


Ala Ala Glu Trp Glu Ile His Phe Ala Gly Gln Gln Thr Glu Phe Lys 
            180                 185                 190         


Ile Leu Ser Leu His Pro Gly Gln Lys Tyr Leu Val Gln Val Arg Cys 
        195                 200                 205             


Lys Pro Asp His Gly Tyr Trp Ser Ala Trp Ser Pro Ala Thr Phe Ile 
    210                 215                 220                 


Gln Ile Pro Ser Asp Phe Thr Met Asn Asp Thr Thr Val Trp Ile Ser 
225                 230                 235                 240 


Val Ala Val Leu Ser Ala Val Ile Cys Leu Ile Ile Val Trp Ala Val 
                245                 250                 255     


Ala Leu Lys Gly Tyr Ser Met Val Thr Cys Ile Phe Pro Pro Val Pro 
            260                 265                 270         


Gly Pro Lys Ile Lys Gly Phe Asp Ala His Leu Leu Glu Lys Gly Lys 
        275                 280                 285             


Ser Glu Glu Leu Leu Ser Ala Leu Gly Cys Gln Asp Phe Pro Pro Thr 
    290                 295                 300                 


Ser Asp Tyr Glu Asp Leu Leu Val Glu Tyr Leu Glu Val Asp Asp Ser 
305                 310                 315                 320 


Glu Asp Gln His Leu Met Ser Val His Ser Lys Glu His Pro Ser Gln 
                325                 330                 335     


Gly Met Lys Pro Thr Tyr Leu Asp Pro Asp Thr Asp Ser Gly Arg Gly 
            340                 345                 350         


Ser Cys Asp Ser Pro Ser Leu Leu Ser Glu Lys Cys Glu Glu Pro Gln 
        355                 360                 365             


Ala Asn Pro Ser Thr Phe Tyr Asp Pro Glu Val Ile Glu Lys Pro Glu 
    370                 375                 380                 


Asn Pro Glu Thr Thr His Thr Trp Asp Pro Gln Cys Ile Ser Met Glu 
385                 390                 395                 400 


Gly Lys Ile Pro Tyr Phe His Ala Gly Gly Ser Lys Cys Ser Thr Trp 
                405                 410                 415     


Pro Leu Pro Gln Pro Ser Gln His Asn Pro Arg Ser Ser Tyr His Asn 
            420                 425                 430         


Ile Thr Asp Val Cys Glu Leu Ala Val Gly Pro Ala Gly Ala Pro Ala 
        435                 440                 445             


Thr Leu Leu Asn Glu Ala Gly Lys Asp Ala Leu Lys Ser Ser Gln Thr 
    450                 455                 460                 


Ile Lys Ser Arg Glu Glu Gly Lys Ala Thr Gln Gln Arg Glu Val Glu 
465                 470                 475                 480 


Ser Phe His Ser Glu Thr Asp Gln Asp Thr Pro Trp Leu Leu Pro Gln 
                485                 490                 495     


Glu Lys Thr Pro Phe Gly Ser Ala Lys Pro Leu Asp Tyr Val Glu Ile 
            500                 505                 510         


His Lys Val Asn Lys Asp Gly Ala Leu Ser Leu Leu Pro Lys Gln Arg 
        515                 520                 525             


Glu Asn Ser Gly Lys Pro Lys Lys Pro Gly Thr Pro Glu Asn Asn Lys 
    530                 535                 540                 


Glu Tyr Ala Lys Val Ser Gly Val Met Asp Asn Asn Ile Leu Val Leu 
545                 550                 555                 560 


Val Pro Asp Pro His Ala Lys Asn Val Ala Cys Phe Glu Glu Ser Ala 
                565                 570                 575     


Lys Glu Ala Pro Pro Ser Leu Glu Gln Asn Gln Ala Glu Lys Ala Leu 
            580                 585                 590         


Ala Asn Phe Thr Ala Thr Ser Ser Lys Cys Arg Leu Gln Leu Gly Gly 
        595                 600                 605             


Leu Asp Tyr Leu Asp Pro Ala Cys Phe Thr His Ser Phe His 
    610                 615                 620         


<210>  338
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  338

Met Gly Arg Val Phe Leu Thr Gly Glu Lys Ala Asn Ser Ile Leu Lys 
1               5                   10                  15      


Arg Tyr Pro Arg Ala Asn Gly Phe Phe Glu Glu Ile Arg Gln Gly Asn 
            20                  25                  30          


Ile Glu Arg Glu Cys Lys Glu Glu Phe Cys Thr Phe Glu Glu Ala Arg 
        35                  40                  45              


Glu Ala Phe Glu Asn Asn Glu Lys Thr Lys Glu Phe Trp Ser Thr Tyr 
    50                  55                  60                  


Thr Lys Ala Gln Gln Gly Glu Ser Asn Arg Gly Ser Asp Trp Phe Gln 
65                  70                  75                  80  


Phe Tyr Leu Thr Phe Pro Leu Ile Phe Gly Leu Phe Ile Ile Leu Leu 
                85                  90                  95      


Val Ile Phe Leu Ile Trp Arg Cys Phe Leu Arg Asn Lys Thr Arg Arg 
            100                 105                 110         


Gln Thr Val Thr Glu Gly His Ile Pro Phe Pro Gln His Leu Asn Ile 
        115                 120                 125             


Ile Thr Pro Pro Pro Pro Pro Asp Glu Val Phe Asp Ser Ser Gly Leu 
    130                 135                 140                 


Ser Pro Gly Phe Leu Gly Tyr Val Val Gly Arg Ser Asp Ser Val Ser 
145                 150                 155                 160 


Thr Arg Leu Ser Asn Cys Asp Pro Pro Pro Thr Tyr Glu Glu Ala Thr 
                165                 170                 175     


Gly Gln Val Asn Leu Gln Arg Ser Glu Thr Glu Pro His Leu Asp Pro 
            180                 185                 190         


Pro Pro Glu Tyr Glu Asp Ile Val Asn Ser Asn Ser Ala Ser Ala Ile 
        195                 200                 205             


Pro Met Val Pro Val Val Thr Thr Ile Lys 
    210                 215             


<210>  339
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  339

Met Arg Gly His Pro Ser Leu Leu Leu Leu Tyr Met Ala Leu Thr Thr 
1               5                   10                  15      


Cys Leu Asp Thr Ser Pro Ser Glu Glu Thr Asp Gln Glu Val Phe Leu 
            20                  25                  30          


Gly Pro Pro Glu Ala Gln Ser Phe Leu Ser Ser His Thr Arg Ile Pro 
        35                  40                  45              


Arg Ala Asn His Trp Asp Leu Glu Leu Leu Thr Pro Gly Asn Leu Glu 
    50                  55                  60                  


Arg Glu Cys Leu Glu Glu Arg Cys Ser Trp Glu Glu Ala Arg Glu Tyr 
65                  70                  75                  80  


Phe Glu Asp Asn Thr Leu Thr Glu Arg Phe Trp Glu Ser Tyr Ile Tyr 
                85                  90                  95      


Asn Gly Lys Gly Gly Arg Gly Arg Val Asp Val Ala Ser Leu Ala Val 
            100                 105                 110         


Gly Leu Thr Gly Gly Ile Leu Leu Ile Val Leu Ala Gly Leu Gly Ala 
        115                 120                 125             


Phe Trp Tyr Leu Arg Trp Arg Gln His Arg Gly Gln Gln Pro Cys Pro 
    130                 135                 140                 


Gln Glu Ala Gly Leu Ile Ser Pro Leu Ser Pro Leu Asn Pro Leu Gly 
145                 150                 155                 160 


Pro Pro Thr Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Gly Leu Pro 
                165                 170                 175     


Thr Tyr Glu Gln Ala Leu Ala Ala Ser Gly Val His Asp Ala Pro Pro 
            180                 185                 190         


Pro Pro Tyr Thr Ser Leu Arg Arg Pro His 
        195                 200         


<210>  340
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  340

Met Glu Pro His Asp Ser Ser His Met Asp Ser Glu Phe Arg Tyr Thr 
1               5                   10                  15      


Leu Phe Pro Ile Val Tyr Ser Ile Ile Phe Val Leu Gly Val Ile Ala 
            20                  25                  30          


Asn Gly Tyr Val Leu Trp Val Phe Ala Arg Leu Tyr Pro Cys Lys Lys 
        35                  40                  45              


Phe Asn Glu Ile Lys Ile Phe Met Val Asn Leu Thr Met Ala Asp Met 
    50                  55                  60                  


Leu Phe Leu Ile Thr Leu Pro Leu Trp Ile Val Tyr Tyr Gln Asn Gln 
65                  70                  75                  80  


Gly Asn Trp Ile Leu Pro Lys Phe Leu Cys Asn Val Ala Gly Cys Leu 
                85                  90                  95      


Phe Phe Ile Asn Thr Tyr Cys Ser Val Ala Phe Leu Gly Val Ile Thr 
            100                 105                 110         


Tyr Asn Arg Phe Gln Ala Val Thr Arg Pro Ile Lys Thr Ala Gln Ala 
        115                 120                 125             


Asn Thr Arg Lys Arg Gly Ile Ser Leu Ser Leu Val Ile Trp Val Ala 
    130                 135                 140                 


Ile Val Gly Ala Ala Ser Tyr Phe Leu Ile Leu Asp Ser Thr Asn Thr 
145                 150                 155                 160 


Val Pro Asp Ser Ala Gly Ser Gly Asn Val Thr Arg Cys Phe Glu His 
                165                 170                 175     


Tyr Glu Lys Gly Ser Val Pro Val Leu Ile Ile His Ile Phe Ile Val 
            180                 185                 190         


Phe Ser Phe Phe Leu Val Phe Leu Ile Ile Leu Phe Cys Asn Leu Val 
        195                 200                 205             


Ile Ile Arg Thr Leu Leu Met Gln Pro Val Gln Gln Gln Arg Asn Ala 
    210                 215                 220                 


Glu Val Lys Arg Arg Ala Leu Trp Met Val Cys Thr Val Leu Ala Val 
225                 230                 235                 240 


Phe Ile Ile Cys Phe Val Pro His His Val Val Gln Leu Pro Trp Thr 
                245                 250                 255     


Leu Ala Glu Leu Gly Phe Gln Asp Ser Lys Phe His Gln Ala Ile Asn 
            260                 265                 270         


Asp Ala His Gln Val Thr Leu Cys Leu Leu Ser Thr Asn Cys Val Leu 
        275                 280                 285             


Asp Pro Val Ile Tyr Cys Phe Leu Thr Lys Lys Phe Arg Lys His Leu 
    290                 295                 300                 


Thr Glu Lys Phe Tyr Ser Met Arg Ser Ser Arg Lys Cys Ser Arg Ala 
305                 310                 315                 320 


Thr Thr Asp Thr Val Thr Glu Val Val Val Pro Phe Asn Gln Ile Pro 
                325                 330                 335     


Gly Asn Ser Leu Lys Asn 
            340         


<210>  341
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  341

Met Lys Ser Pro Phe Tyr Arg Cys Gln Asn Thr Thr Ser Val Glu Lys 
1               5                   10                  15      


Gly Asn Ser Ala Val Met Gly Gly Val Leu Phe Ser Thr Gly Leu Leu 
            20                  25                  30          


Gly Asn Leu Leu Ala Leu Gly Leu Leu Ala Arg Ser Gly Leu Gly Trp 
        35                  40                  45              


Cys Ser Arg Arg Pro Leu Arg Pro Leu Pro Ser Val Phe Tyr Met Leu 
    50                  55                  60                  


Val Cys Gly Leu Thr Val Thr Asp Leu Leu Gly Lys Cys Leu Leu Ser 
65                  70                  75                  80  


Pro Val Val Leu Ala Ala Tyr Ala Gln Asn Arg Ser Leu Arg Val Leu 
                85                  90                  95      


Ala Pro Ala Leu Asp Asn Ser Leu Cys Gln Ala Phe Ala Phe Phe Met 
            100                 105                 110         


Ser Phe Phe Gly Leu Ser Ser Thr Leu Gln Leu Leu Ala Met Ala Leu 
        115                 120                 125             


Glu Cys Trp Leu Ser Leu Gly His Pro Phe Phe Tyr Arg Arg His Ile 
    130                 135                 140                 


Thr Leu Arg Leu Gly Ala Leu Val Ala Pro Val Val Ser Ala Phe Ser 
145                 150                 155                 160 


Leu Ala Phe Cys Ala Leu Pro Phe Met Gly Phe Gly Lys Phe Val Gln 
                165                 170                 175     


Tyr Cys Pro Gly Thr Trp Cys Phe Ile Gln Met Val His Glu Glu Gly 
            180                 185                 190         


Ser Leu Ser Val Leu Gly Tyr Ser Val Leu Tyr Ser Ser Leu Met Ala 
        195                 200                 205             


Leu Leu Val Leu Ala Thr Val Leu Cys Asn Leu Gly Ala Met Arg Asn 
    210                 215                 220                 


Leu Tyr Ala Met His Arg Arg Leu Gln Arg His Pro Arg Ser Cys Thr 
225                 230                 235                 240 


Arg Asp Cys Ala Glu Pro Arg Ala Asp Gly Arg Glu Ala Ser Pro Gln 
                245                 250                 255     


Pro Leu Glu Glu Leu Asp His Leu Leu Leu Leu Ala Leu Met Thr Val 
            260                 265                 270         


Leu Phe Thr Met Cys Ser Leu Pro Val Ile Tyr Arg Ala Tyr Tyr Gly 
        275                 280                 285             


Ala Phe Lys Asp Val Lys Glu Lys Asn Arg Thr Ser Glu Glu Ala Glu 
    290                 295                 300                 


Asp Leu Arg Ala Leu Arg Phe Leu Ser Val Ile Ser Ile Val Asp Pro 
305                 310                 315                 320 


Trp Ile Phe Ile Ile Phe Arg Ser Pro Val Phe Arg Ile Phe Phe His 
                325                 330                 335     


Lys Ile Phe Ile Arg Pro Leu Arg Tyr Arg Ser Arg Cys Ser Asn Ser 
            340                 345                 350         


Thr Asn Met Glu Ser Ser Leu 
        355                 


<210>  342
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  342

Met Ser Pro Cys Gly Pro Leu Asn Leu Ser Leu Ala Gly Glu Ala Thr 
1               5                   10                  15      


Thr Cys Ala Ala Pro Trp Val Pro Asn Thr Ser Ala Val Pro Pro Ser 
            20                  25                  30          


Gly Ala Ser Pro Ala Leu Pro Ile Phe Ser Met Thr Leu Gly Ala Val 
        35                  40                  45              


Ser Asn Leu Leu Ala Leu Ala Leu Leu Ala Gln Ala Ala Gly Arg Leu 
    50                  55                  60                  


Arg Arg Arg Arg Ser Ala Ala Thr Phe Leu Leu Phe Val Ala Ser Leu 
65                  70                  75                  80  


Leu Ala Thr Asp Leu Ala Gly His Val Ile Pro Gly Ala Leu Val Leu 
                85                  90                  95      


Arg Leu Tyr Thr Ala Gly Arg Ala Pro Ala Gly Gly Ala Cys His Phe 
            100                 105                 110         


Leu Gly Gly Cys Met Val Phe Phe Gly Leu Cys Pro Leu Leu Leu Gly 
        115                 120                 125             


Cys Gly Met Ala Val Glu Arg Cys Val Gly Val Thr Arg Pro Leu Leu 
    130                 135                 140                 


His Ala Ala Arg Val Ser Val Ala Arg Ala Arg Leu Ala Leu Ala Ala 
145                 150                 155                 160 


Val Ala Ala Val Ala Leu Ala Val Ala Leu Leu Pro Leu Ala Arg Val 
                165                 170                 175     


Gly Arg Tyr Glu Leu Gln Tyr Pro Gly Thr Trp Cys Phe Ile Gly Leu 
            180                 185                 190         


Gly Pro Pro Gly Gly Trp Arg Gln Ala Leu Leu Ala Gly Leu Phe Ala 
        195                 200                 205             


Ser Leu Gly Leu Val Ala Leu Leu Ala Ala Leu Val Cys Asn Thr Leu 
    210                 215                 220                 


Ser Gly Leu Ala Leu Leu Arg Ala Arg Trp Arg Arg Arg Ser Arg Arg 
225                 230                 235                 240 


Pro Pro Pro Ala Ser Gly Pro Asp Ser Arg Arg Arg Trp Gly Ala His 
                245                 250                 255     


Gly Pro Arg Ser Ala Ser Ala Ser Ser Ala Ser Ser Ile Ala Ser Ala 
            260                 265                 270         


Ser Thr Phe Phe Gly Gly Ser Arg Ser Ser Gly Ser Ala Arg Arg Ala 
        275                 280                 285             


Arg Ala His Asp Val Glu Met Val Gly Gln Leu Val Gly Ile Met Val 
    290                 295                 300                 


Val Ser Cys Ile Cys Trp Ser Pro Met Leu Val Leu Val Ala Leu Ala 
305                 310                 315                 320 


Val Gly Gly Trp Ser Ser Thr Ser Leu Gln Arg Pro Leu Phe Leu Ala 
                325                 330                 335     


Val Arg Leu Ala Ser Trp Asn Gln Ile Leu Asp Pro Trp Val Tyr Ile 
            340                 345                 350         


Leu Leu Arg Gln Ala Val Leu Arg Gln Leu Leu Arg Leu Leu Pro Pro 
        355                 360                 365             


Arg Ala Gly Ala Lys Gly Gly Pro Ala Gly Leu Gly Leu Thr Pro Ser 
    370                 375                 380                 


Ala Trp Glu Ala Ser Ser Leu Arg Ser Ser Arg His Ser Gly Leu Ser 
385                 390                 395                 400 


His Phe 
        


<210>  343
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  343

Met Gly Asn Ala Ser Asn Asp Ser Gln Ser Glu Asp Cys Glu Thr Arg 
1               5                   10                  15      


Gln Trp Leu Pro Pro Gly Glu Ser Pro Ala Ile Ser Ser Val Met Phe 
            20                  25                  30          


Ser Ala Gly Val Leu Gly Asn Leu Ile Ala Leu Ala Leu Leu Ala Arg 
        35                  40                  45              


Arg Trp Arg Gly Asp Val Gly Cys Ser Ala Gly Arg Arg Ser Ser Leu 
    50                  55                  60                  


Ser Leu Phe His Val Leu Val Thr Glu Leu Val Phe Thr Asp Leu Leu 
65                  70                  75                  80  


Gly Thr Cys Leu Ile Ser Pro Val Val Leu Ala Ser Tyr Ala Arg Asn 
                85                  90                  95      


Gln Thr Leu Val Ala Leu Ala Pro Glu Ser Arg Ala Cys Thr Tyr Phe 
            100                 105                 110         


Ala Phe Ala Met Thr Phe Phe Ser Leu Ala Thr Met Leu Met Leu Phe 
        115                 120                 125             


Ala Met Ala Leu Glu Arg Tyr Leu Ser Ile Gly His Pro Tyr Phe Tyr 
    130                 135                 140                 


Gln Arg Arg Val Ser Arg Ser Gly Gly Leu Ala Val Leu Pro Val Ile 
145                 150                 155                 160 


Tyr Ala Val Ser Leu Leu Phe Cys Ser Leu Pro Leu Leu Asp Tyr Gly 
                165                 170                 175     


Gln Tyr Val Gln Tyr Cys Pro Gly Thr Trp Cys Phe Ile Arg His Gly 
            180                 185                 190         


Arg Thr Ala Tyr Leu Gln Leu Tyr Ala Thr Leu Leu Leu Leu Leu Ile 
        195                 200                 205             


Val Ser Val Leu Ala Cys Asn Phe Ser Val Ile Leu Asn Leu Ile Arg 
    210                 215                 220                 


Met His Arg Arg Ser Arg Arg Ser Arg Cys Gly Pro Ser Leu Gly Ser 
225                 230                 235                 240 


Gly Arg Gly Gly Pro Gly Ala Arg Arg Arg Gly Glu Arg Val Ser Met 
                245                 250                 255     


Ala Glu Glu Thr Asp His Leu Ile Leu Leu Ala Ile Met Thr Ile Thr 
            260                 265                 270         


Phe Ala Val Cys Ser Leu Pro Phe Thr Ile Phe Ala Tyr Met Asn Glu 
        275                 280                 285             


Thr Ser Ser Arg Lys Glu Lys Trp Asp Leu Gln Ala Leu Arg Phe Leu 
    290                 295                 300                 


Ser Ile Asn Ser Ile Ile Asp Pro Trp Val Phe Ala Ile Leu Arg Pro 
305                 310                 315                 320 


Pro Val Leu Arg Leu Met Arg Ser Val Leu Cys Cys Arg Ile Ser Leu 
                325                 330                 335     


Arg Thr Gln Asp Ala Thr Gln Thr Ser Cys Ser Thr Gln Ser Asp Ala 
            340                 345                 350         


Ser Lys Gln Ala Asp Leu 
        355             


<210>  344
<211>  425
<212>  PRT
<213>  Homo sapiens

<400>  344

Met Lys Glu Thr Arg Gly Tyr Gly Gly Asp Ala Pro Phe Cys Thr Arg 
1               5                   10                  15      


Leu Asn His Ser Tyr Thr Gly Met Trp Ala Pro Glu Arg Ser Ala Glu 
            20                  25                  30          


Ala Arg Gly Asn Leu Thr Arg Pro Pro Gly Ser Gly Glu Asp Cys Gly 
        35                  40                  45              


Ser Val Ser Val Ala Phe Pro Ile Thr Met Leu Leu Thr Gly Phe Val 
    50                  55                  60                  


Gly Asn Ala Leu Ala Met Leu Leu Val Ser Arg Ser Tyr Arg Arg Arg 
65                  70                  75                  80  


Glu Ser Lys Arg Lys Lys Ser Phe Leu Leu Cys Ile Gly Trp Leu Ala 
                85                  90                  95      


Leu Thr Asp Leu Val Gly Gln Leu Leu Thr Thr Pro Val Val Ile Val 
            100                 105                 110         


Val Tyr Leu Ser Lys Gln Arg Trp Glu His Ile Asp Pro Ser Gly Arg 
        115                 120                 125             


Leu Cys Thr Phe Phe Gly Leu Thr Met Thr Val Phe Gly Leu Ser Ser 
    130                 135                 140                 


Leu Phe Ile Ala Ser Ala Met Ala Val Glu Arg Ala Leu Ala Ile Arg 
145                 150                 155                 160 


Ala Pro His Trp Tyr Ala Ser His Met Lys Thr Arg Ala Thr Arg Ala 
                165                 170                 175     


Val Leu Leu Gly Val Trp Leu Ala Val Leu Ala Phe Ala Leu Leu Pro 
            180                 185                 190         


Val Leu Gly Val Gly Gln Tyr Thr Val Gln Trp Pro Gly Thr Trp Cys 
        195                 200                 205             


Phe Ile Ser Thr Gly Arg Gly Gly Asn Gly Thr Ser Ser Ser His Asn 
    210                 215                 220                 


Trp Gly Asn Leu Phe Phe Ala Ser Ala Phe Ala Phe Leu Gly Leu Leu 
225                 230                 235                 240 


Ala Leu Thr Val Thr Phe Ser Cys Asn Leu Ala Thr Ile Lys Ala Leu 
                245                 250                 255     


Val Ser Arg Cys Arg Ala Lys Ala Thr Ala Ser Gln Ser Ser Ala Gln 
            260                 265                 270         


Trp Gly Arg Ile Thr Thr Glu Thr Ala Ile Gln Leu Met Gly Ile Met 
        275                 280                 285             


Cys Val Leu Ser Val Cys Trp Ser Pro Leu Leu Ile Met Met Leu Lys 
    290                 295                 300                 


Met Ile Phe Asn Gln Thr Ser Val Glu His Cys Lys Thr His Thr Glu 
305                 310                 315                 320 


Lys Gln Lys Glu Cys Asn Phe Phe Leu Ile Ala Val Arg Leu Ala Ser 
                325                 330                 335     


Leu Asn Gln Ile Leu Asp Pro Trp Val Tyr Leu Leu Leu Arg Lys Ile 
            340                 345                 350         


Leu Leu Arg Lys Phe Cys Gln Met Arg Lys Arg Arg Leu Arg Glu Gln 
        355                 360                 365             


Ala Pro Leu Leu Pro Thr Ser Thr Val Ile Asp Pro Ser Arg Phe Cys 
    370                 375                 380                 


Ala Gln Pro Phe Arg Trp Phe Leu Asp Leu Ser Phe Pro Ala Met Ser 
385                 390                 395                 400 


Ser Ser His Pro Gln Leu Pro Leu Thr Leu Ala Ser Phe Lys Leu Leu 
                405                 410                 415     


Arg Glu Pro Cys Ser Val Gln Leu Ser 
            420                 425 


<210>  345
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  345

Met Ser Thr Pro Gly Val Asn Ser Ser Ala Ser Leu Ser Pro Asp Arg 
1               5                   10                  15      


Leu Asn Ser Pro Val Thr Ile Pro Ala Val Met Phe Ile Phe Gly Val 
            20                  25                  30          


Val Gly Asn Leu Val Ala Ile Val Val Leu Cys Lys Ser Arg Lys Glu 
        35                  40                  45              


Gln Lys Glu Thr Thr Phe Tyr Thr Leu Val Cys Gly Leu Ala Val Thr 
    50                  55                  60                  


Asp Leu Leu Gly Thr Leu Leu Val Ser Pro Val Thr Ile Ala Thr Tyr 
65                  70                  75                  80  


Met Lys Gly Gln Trp Pro Gly Gly Gln Pro Leu Cys Glu Tyr Ser Thr 
                85                  90                  95      


Phe Ile Leu Leu Phe Phe Ser Leu Ser Gly Leu Ser Ile Ile Cys Ala 
            100                 105                 110         


Met Ser Val Glu Arg Tyr Leu Ala Ile Asn His Ala Tyr Phe Tyr Ser 
        115                 120                 125             


His Tyr Val Asp Lys Arg Leu Ala Gly Leu Thr Leu Phe Ala Val Tyr 
    130                 135                 140                 


Ala Ser Asn Val Leu Phe Cys Ala Leu Pro Asn Met Gly Leu Gly Ser 
145                 150                 155                 160 


Ser Arg Leu Gln Tyr Pro Asp Thr Trp Cys Phe Ile Asp Trp Thr Thr 
                165                 170                 175     


Asn Val Thr Ala His Ala Ala Tyr Ser Tyr Met Tyr Ala Gly Phe Ser 
            180                 185                 190         


Ser Phe Leu Ile Leu Ala Thr Val Leu Cys Asn Val Leu Val Cys Gly 
        195                 200                 205             


Ala Leu Leu Arg Met His Arg Gln Phe Met Arg Arg Thr Ser Leu Gly 
    210                 215                 220                 


Thr Glu Gln His His Ala Ala Ala Ala Ala Ser Val Ala Ser Arg Gly 
225                 230                 235                 240 


His Pro Ala Ala Ser Pro Ala Leu Pro Arg Leu Ser Asp Phe Arg Arg 
                245                 250                 255     


Arg Arg Ser Phe Arg Arg Ile Ala Gly Ala Glu Ile Gln Met Val Ile 
            260                 265                 270         


Leu Leu Ile Ala Thr Ser Leu Val Val Leu Ile Cys Ser Ile Pro Leu 
        275                 280                 285             


Val Val Arg Val Phe Val Asn Gln Leu Tyr Gln Pro Ser Leu Glu Arg 
    290                 295                 300                 


Glu Val Ser Lys Asn Pro Asp Leu Gln Ala Ile Arg Ile Ala Ser Val 
305                 310                 315                 320 


Asn Pro Ile Leu Asp Pro Trp Ile Tyr Ile Leu Leu Arg Lys Thr Val 
                325                 330                 335     


Leu Ser Lys Ala Ile Glu Lys Ile Lys Cys Leu Phe Cys Arg Ile Gly 
            340                 345                 350         


Gly Ser Arg Arg Glu Arg Ser Gly Gln His Cys Ser Asp Ser Gln Arg 
        355                 360                 365             


Thr Ser Ser Ala Met Ser Gly His Ser Arg Ser Phe Ile Ser Arg Glu 
    370                 375                 380                 


Leu Lys Glu Ile Ser Ser Thr Ser Gln Thr Leu Leu Pro Asp Leu Ser 
385                 390                 395                 400 


Leu Pro Asp Leu Ser Glu Asn Gly Leu Gly Gly Arg Asn Leu Leu Pro 
                405                 410                 415     


Gly Val Pro Gly Met Gly Leu Ala Gln Glu Asp Thr Thr Ser Leu Arg 
            420                 425                 430         


Thr Leu Arg Ile Ser Glu Thr Ser Asp Ser Ser Gln Gly Gln Asp Ser 
        435                 440                 445             


Glu Ser Val Leu Leu Val Asp Glu Ala Gly Gly Ser Gly Arg Ala Gly 
    450                 455                 460                 


Pro Ala Pro Lys Gly Ser Ser Leu Gln Val Thr Phe Pro Ser Glu Thr 
465                 470                 475                 480 


Leu Asn Leu Ser Glu Lys Cys Ile 
                485             


<210>  346
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  346

Met Ser Met Asn Asn Ser Lys Gln Leu Val Ser Pro Ala Ala Ala Leu 
1               5                   10                  15      


Leu Ser Asn Thr Thr Cys Gln Thr Glu Asn Arg Leu Ser Val Phe Phe 
            20                  25                  30          


Ser Val Ile Phe Met Thr Val Gly Ile Leu Ser Asn Ser Leu Ala Ile 
        35                  40                  45              


Ala Ile Leu Met Lys Ala Tyr Gln Arg Phe Arg Gln Lys Ser Lys Ala 
    50                  55                  60                  


Ser Phe Leu Leu Leu Ala Ser Gly Leu Val Ile Thr Asp Phe Phe Gly 
65                  70                  75                  80  


His Leu Ile Asn Gly Ala Ile Ala Val Phe Val Tyr Ala Ser Asp Lys 
                85                  90                  95      


Glu Trp Ile Arg Phe Asp Gln Ser Asn Val Leu Cys Ser Ile Phe Gly 
            100                 105                 110         


Ile Cys Met Val Phe Ser Gly Leu Cys Pro Leu Leu Leu Gly Ser Val 
        115                 120                 125             


Met Ala Ile Glu Arg Cys Ile Gly Val Thr Lys Pro Ile Phe His Ser 
    130                 135                 140                 


Thr Lys Ile Thr Ser Lys His Val Lys Met Met Leu Ser Gly Val Cys 
145                 150                 155                 160 


Leu Phe Ala Val Phe Ile Ala Leu Leu Pro Ile Leu Gly His Arg Asp 
                165                 170                 175     


Tyr Lys Ile Gln Ala Ser Arg Thr Trp Cys Phe Tyr Asn Thr Glu Asp 
            180                 185                 190         


Ile Lys Asp Trp Glu Asp Arg Phe Tyr Leu Leu Leu Phe Ser Phe Leu 
        195                 200                 205             


Gly Leu Leu Ala Leu Gly Val Ser Leu Leu Cys Asn Ala Ile Thr Gly 
    210                 215                 220                 


Ile Thr Leu Leu Arg Val Lys Phe Lys Ser Gln Gln His Arg Gln Gly 
225                 230                 235                 240 


Arg Ser His His Leu Glu Met Val Ile Gln Leu Leu Ala Ile Met Cys 
                245                 250                 255     


Val Ser Cys Ile Cys Trp Ser Pro Phe Leu Val Thr Met Ala Asn Ile 
            260                 265                 270         


Gly Ile Asn Gly Asn His Ser Leu Glu Thr Cys Glu Thr Thr Leu Phe 
        275                 280                 285             


Ala Leu Arg Met Ala Thr Trp Asn Gln Ile Leu Asp Pro Trp Val Tyr 
    290                 295                 300                 


Ile Leu Leu Arg Lys Ala Val Leu Lys Asn Leu Tyr Lys Leu Ala Ser 
305                 310                 315                 320 


Gln Cys Cys Gly Val His Val Ile Ser Leu His Ile Trp Glu Leu Ser 
                325                 330                 335     


Ser Ile Lys Asn Ser Leu Lys Val Ala Ala Ile Ser Glu Ser Pro Val 
            340                 345                 350         


Ala Glu Lys Ser Ala Ser Thr 
        355                 


<210>  347
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  347

Met Ala Trp Ala Ala Leu Leu Gly Leu Leu Ala Ala Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Ser Arg Arg Arg Thr Arg Arg Pro Gly Glu Pro Pro Leu 
            20                  25                  30          


Asp Leu Gly Ser Ile Pro Trp Leu Gly Tyr Ala Leu Asp Phe Gly Lys 
        35                  40                  45              


Asp Ala Ala Ser Phe Leu Thr Arg Met Lys Glu Lys His Gly Asp Ile 
    50                  55                  60                  


Phe Thr Ile Leu Val Gly Gly Arg Tyr Val Thr Val Leu Leu Asp Pro 
65                  70                  75                  80  


His Ser Tyr Asp Ala Val Val Trp Glu Pro Arg Thr Arg Leu Asp Phe 
                85                  90                  95      


His Ala Tyr Ala Ile Phe Leu Met Glu Arg Ile Phe Asp Val Gln Leu 
            100                 105                 110         


Pro His Tyr Ser Pro Ser Asp Glu Lys Ala Arg Met Lys Leu Thr Leu 
        115                 120                 125             


Leu His Arg Glu Leu Gln Ala Leu Thr Glu Ala Met Tyr Thr Asn Leu 
    130                 135                 140                 


His Ala Val Leu Leu Gly Asp Ala Thr Glu Ala Gly Ser Gly Trp His 
145                 150                 155                 160 


Glu Met Gly Leu Leu Asp Phe Ser Tyr Ser Phe Leu Leu Arg Ala Gly 
                165                 170                 175     


Tyr Leu Thr Leu Tyr Gly Ile Glu Ala Leu Pro Arg Thr His Glu Ser 
            180                 185                 190         


Gln Ala Gln Asp Arg Val His Ser Ala Asp Val Phe His Thr Phe Arg 
        195                 200                 205             


Gln Leu Asp Arg Leu Leu Pro Lys Leu Ala Arg Gly Ser Leu Ser Val 
    210                 215                 220                 


Gly Asp Lys Asp His Met Cys Ser Val Lys Ser Arg Leu Trp Lys Leu 
225                 230                 235                 240 


Leu Ser Pro Ala Arg Leu Ala Arg Arg Ala His Arg Ser Lys Trp Leu 
                245                 250                 255     


Glu Ser Tyr Leu Leu His Leu Glu Glu Met Gly Val Ser Glu Glu Met 
            260                 265                 270         


Gln Ala Arg Ala Leu Val Leu Gln Leu Trp Ala Thr Gln Gly Asn Met 
        275                 280                 285             


Gly Pro Ala Ala Phe Trp Leu Leu Leu Phe Leu Leu Lys Asn Pro Glu 
    290                 295                 300                 


Ala Leu Ala Ala Val Arg Gly Glu Leu Glu Ser Ile Leu Trp Gln Ala 
305                 310                 315                 320 


Glu Gln Pro Val Ser Gln Thr Thr Thr Leu Pro Gln Lys Val Leu Asp 
                325                 330                 335     


Ser Thr Pro Val Leu Asp Ser Val Leu Ser Glu Ser Leu Arg Leu Thr 
            340                 345                 350         


Ala Ala Pro Phe Ile Thr Arg Glu Val Val Val Asp Leu Ala Met Pro 
        355                 360                 365             


Met Ala Asp Gly Arg Glu Phe Asn Leu Arg Arg Gly Asp Arg Leu Leu 
    370                 375                 380                 


Leu Phe Pro Phe Leu Ser Pro Gln Arg Asp Pro Glu Ile Tyr Thr Asp 
385                 390                 395                 400 


Pro Glu Val Phe Lys Tyr Asn Arg Phe Leu Asn Pro Asp Gly Ser Glu 
                405                 410                 415     


Lys Lys Asp Phe Tyr Lys Asp Gly Lys Arg Leu Lys Asn Tyr Asn Met 
            420                 425                 430         


Pro Trp Gly Ala Gly His Asn His Cys Leu Gly Arg Ser Tyr Ala Val 
        435                 440                 445             


Asn Ser Ile Lys Gln Phe Val Phe Leu Val Leu Val His Leu Asp Leu 
    450                 455                 460                 


Glu Leu Ile Asn Ala Asp Val Glu Ile Pro Glu Phe Asp Leu Ser Arg 
465                 470                 475                 480 


Tyr Gly Phe Gly Leu Met Gln Pro Glu His Asp Val Pro Val Arg Tyr 
                485                 490                 495     


Arg Ile Arg Pro 
            500 


<210>  348
<211>  599
<212>  PRT
<213>  Homo sapiens

<400>  348

Met Ser Arg Ser Leu Leu Leu Trp Phe Leu Leu Phe Leu Leu Leu Leu 
1               5                   10                  15      


Pro Pro Leu Pro Val Leu Leu Ala Asp Pro Gly Ala Pro Thr Pro Val 
            20                  25                  30          


Asn Pro Cys Cys Tyr Tyr Pro Cys Gln His Gln Gly Ile Cys Val Arg 
        35                  40                  45              


Phe Gly Leu Asp Arg Tyr Gln Cys Asp Cys Thr Arg Thr Gly Tyr Ser 
    50                  55                  60                  


Gly Pro Asn Cys Thr Ile Pro Gly Leu Trp Thr Trp Leu Arg Asn Ser 
65                  70                  75                  80  


Leu Arg Pro Ser Pro Ser Phe Thr His Phe Leu Leu Thr His Gly Arg 
                85                  90                  95      


Trp Phe Trp Glu Phe Val Asn Ala Thr Phe Ile Arg Glu Met Leu Met 
            100                 105                 110         


Arg Leu Val Leu Thr Val Arg Ser Asn Leu Ile Pro Ser Pro Pro Thr 
        115                 120                 125             


Tyr Asn Ser Ala His Asp Tyr Ile Ser Trp Glu Ser Phe Ser Asn Val 
    130                 135                 140                 


Ser Tyr Tyr Thr Arg Ile Leu Pro Ser Val Pro Lys Asp Cys Pro Thr 
145                 150                 155                 160 


Pro Met Gly Thr Lys Gly Lys Lys Gln Leu Pro Asp Ala Gln Leu Leu 
                165                 170                 175     


Ala Arg Arg Phe Leu Leu Arg Arg Lys Phe Ile Pro Asp Pro Gln Gly 
            180                 185                 190         


Thr Asn Leu Met Phe Ala Phe Phe Ala Gln His Phe Thr His Gln Phe 
        195                 200                 205             


Phe Lys Thr Ser Gly Lys Met Gly Pro Gly Phe Thr Lys Ala Leu Gly 
    210                 215                 220                 


His Gly Val Asp Leu Gly His Ile Tyr Gly Asp Asn Leu Glu Arg Gln 
225                 230                 235                 240 


Tyr Gln Leu Arg Leu Phe Lys Asp Gly Lys Leu Lys Tyr Gln Val Leu 
                245                 250                 255     


Asp Gly Glu Met Tyr Pro Pro Ser Val Glu Glu Ala Pro Val Leu Met 
            260                 265                 270         


His Tyr Pro Arg Gly Ile Pro Pro Gln Ser Gln Met Ala Val Gly Gln 
        275                 280                 285             


Glu Val Phe Gly Leu Leu Pro Gly Leu Met Leu Tyr Ala Thr Leu Trp 
    290                 295                 300                 


Leu Arg Glu His Asn Arg Val Cys Asp Leu Leu Lys Ala Glu His Pro 
305                 310                 315                 320 


Thr Trp Gly Asp Glu Gln Leu Phe Gln Thr Thr Arg Leu Ile Leu Ile 
                325                 330                 335     


Gly Glu Thr Ile Lys Ile Val Ile Glu Glu Tyr Val Gln Gln Leu Ser 
            340                 345                 350         


Gly Tyr Phe Leu Gln Leu Lys Phe Asp Pro Glu Leu Leu Phe Gly Val 
        355                 360                 365             


Gln Phe Gln Tyr Arg Asn Arg Ile Ala Met Glu Phe Asn His Leu Tyr 
    370                 375                 380                 


His Trp His Pro Leu Met Pro Asp Ser Phe Lys Val Gly Ser Gln Glu 
385                 390                 395                 400 


Tyr Ser Tyr Glu Gln Phe Leu Phe Asn Thr Ser Met Leu Val Asp Tyr 
                405                 410                 415     


Gly Val Glu Ala Leu Val Asp Ala Phe Ser Arg Gln Ile Ala Gly Arg 
            420                 425                 430         


Ile Gly Gly Gly Arg Asn Met Asp His His Ile Leu His Val Ala Val 
        435                 440                 445             


Asp Val Ile Arg Glu Ser Arg Glu Met Arg Leu Gln Pro Phe Asn Glu 
    450                 455                 460                 


Tyr Arg Lys Arg Phe Gly Met Lys Pro Tyr Thr Ser Phe Gln Glu Leu 
465                 470                 475                 480 


Val Gly Glu Lys Glu Met Ala Ala Glu Leu Glu Glu Leu Tyr Gly Asp 
                485                 490                 495     


Ile Asp Ala Leu Glu Phe Tyr Pro Gly Leu Leu Leu Glu Lys Cys His 
            500                 505                 510         


Pro Asn Ser Ile Phe Gly Glu Ser Met Ile Glu Ile Gly Ala Pro Phe 
        515                 520                 525             


Ser Leu Lys Gly Leu Leu Gly Asn Pro Ile Cys Ser Pro Glu Tyr Trp 
    530                 535                 540                 


Lys Pro Ser Thr Phe Gly Gly Glu Val Gly Phe Asn Ile Val Lys Thr 
545                 550                 555                 560 


Ala Thr Leu Lys Lys Leu Val Cys Leu Asn Thr Lys Thr Cys Pro Tyr 
                565                 570                 575     


Val Ser Phe Arg Val Pro Asp Ala Ser Gln Asp Asp Gly Pro Ala Val 
            580                 585                 590         


Glu Arg Pro Ser Thr Glu Leu 
        595                 


<210>  349
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  349

Met Ala Lys Arg Thr Lys Lys Val Gly Ile Val Gly Lys Tyr Gly Thr 
1               5                   10                  15      


Arg Tyr Gly Ala Ser Leu Arg Lys Met Val Lys Lys Ile Glu Ile Ser 
            20                  25                  30          


Gln His Ala Lys Tyr Thr Cys Ser Phe Cys Gly Lys Thr Lys Met Lys 
        35                  40                  45              


Arg Arg Ala Val Gly Ile Trp His Cys Gly Ser Cys Met Lys Thr Val 
    50                  55                  60                  


Ala Gly Gly Ala Trp Thr Tyr Asn Thr Thr Ser Ala Val Thr Val Lys 
65                  70                  75                  80  


Ser Ala Ile Arg Arg Leu Lys Glu Leu Lys Asp Gln 
                85                  90          


<210>  350
<211>  1220
<212>  PRT
<213>  Homo sapiens

<400>  350

Met Ala Gln Phe Pro Thr Pro Phe Gly Gly Ser Leu Asp Ile Trp Ala 
1               5                   10                  15      


Ile Thr Val Glu Glu Arg Ala Lys His Asp Gln Gln Phe His Ser Leu 
            20                  25                  30          


Lys Pro Ile Ser Gly Phe Ile Thr Gly Asp Gln Ala Arg Asn Phe Phe 
        35                  40                  45              


Phe Gln Ser Gly Leu Pro Gln Pro Val Leu Ala Gln Ile Trp Ala Leu 
    50                  55                  60                  


Ala Asp Met Asn Asn Asp Gly Arg Met Asp Gln Val Glu Phe Ser Ile 
65                  70                  75                  80  


Ala Met Lys Leu Ile Lys Leu Lys Leu Gln Gly Tyr Gln Leu Pro Ser 
                85                  90                  95      


Ala Leu Pro Pro Val Met Lys Gln Gln Pro Val Ala Ile Ser Ser Ala 
            100                 105                 110         


Pro Ala Phe Gly Met Gly Gly Ile Ala Ser Met Pro Pro Leu Thr Ala 
        115                 120                 125             


Val Ala Pro Val Pro Met Gly Ser Ile Pro Val Val Gly Met Ser Pro 
    130                 135                 140                 


Thr Leu Val Ser Ser Val Pro Thr Ala Ala Val Pro Pro Leu Ala Asn 
145                 150                 155                 160 


Gly Ala Pro Pro Val Ile Gln Pro Leu Pro Ala Phe Ala His Pro Ala 
                165                 170                 175     


Ala Thr Leu Pro Lys Ser Ser Ser Phe Ser Arg Ser Gly Pro Gly Ser 
            180                 185                 190         


Gln Leu Asn Thr Lys Leu Gln Lys Ala Gln Ser Phe Asp Val Ala Ser 
        195                 200                 205             


Val Pro Pro Val Ala Glu Trp Ala Val Pro Gln Ser Ser Arg Leu Lys 
    210                 215                 220                 


Tyr Arg Gln Leu Phe Asn Ser His Asp Lys Thr Met Ser Gly His Leu 
225                 230                 235                 240 


Thr Gly Pro Gln Ala Arg Thr Ile Leu Met Gln Ser Ser Leu Pro Gln 
                245                 250                 255     


Ala Gln Leu Ala Ser Ile Trp Asn Leu Ser Asp Ile Asp Gln Asp Gly 
            260                 265                 270         


Lys Leu Thr Ala Glu Glu Phe Ile Leu Ala Met His Leu Ile Asp Val 
        275                 280                 285             


Ala Met Ser Gly Gln Pro Leu Pro Pro Val Leu Pro Pro Glu Tyr Ile 
    290                 295                 300                 


Pro Pro Ser Phe Arg Arg Val Arg Ser Gly Ser Gly Ile Ser Val Ile 
305                 310                 315                 320 


Ser Ser Thr Ser Val Asp Gln Arg Leu Pro Glu Glu Pro Val Leu Glu 
                325                 330                 335     


Asp Glu Gln Gln Gln Leu Glu Lys Lys Leu Pro Val Thr Phe Glu Asp 
            340                 345                 350         


Lys Lys Arg Glu Asn Phe Glu Arg Gly Asn Leu Glu Leu Glu Lys Arg 
        355                 360                 365             


Arg Gln Ala Leu Leu Glu Gln Gln Arg Lys Glu Gln Glu Arg Leu Ala 
    370                 375                 380                 


Gln Leu Glu Arg Ala Glu Gln Glu Arg Lys Glu Arg Glu Arg Gln Glu 
385                 390                 395                 400 


Gln Glu Arg Lys Arg Gln Leu Glu Leu Glu Lys Gln Leu Glu Lys Gln 
                405                 410                 415     


Arg Glu Leu Glu Arg Gln Arg Glu Glu Glu Arg Arg Lys Glu Ile Glu 
            420                 425                 430         


Arg Arg Glu Ala Ala Lys Arg Glu Leu Glu Arg Gln Arg Gln Leu Glu 
        435                 440                 445             


Trp Glu Arg Asn Arg Arg Gln Glu Leu Leu Asn Gln Arg Asn Lys Glu 
    450                 455                 460                 


Gln Glu Asp Ile Val Val Leu Lys Ala Lys Lys Lys Thr Leu Glu Phe 
465                 470                 475                 480 


Glu Leu Glu Ala Leu Asn Asp Lys Lys His Gln Leu Glu Gly Lys Leu 
                485                 490                 495     


Gln Asp Ile Arg Cys Arg Leu Thr Thr Gln Arg Gln Glu Ile Glu Ser 
            500                 505                 510         


Thr Asn Lys Ser Arg Glu Leu Arg Ile Ala Glu Ile Thr His Leu Gln 
        515                 520                 525             


Gln Gln Leu Gln Glu Ser Gln Gln Met Leu Gly Arg Leu Ile Pro Glu 
    530                 535                 540                 


Lys Gln Ile Leu Asn Asp Gln Leu Lys Gln Val Gln Gln Asn Ser Leu 
545                 550                 555                 560 


His Arg Asp Ser Leu Val Thr Leu Lys Arg Ala Leu Glu Ala Lys Glu 
                565                 570                 575     


Leu Ala Arg Gln His Leu Arg Asp Gln Leu Asp Glu Val Glu Lys Glu 
            580                 585                 590         


Thr Arg Ser Lys Leu Gln Glu Ile Asp Ile Phe Asn Asn Gln Leu Lys 
        595                 600                 605             


Glu Leu Arg Glu Ile His Asn Lys Gln Gln Leu Gln Lys Gln Lys Ser 
    610                 615                 620                 


Met Glu Ala Glu Arg Leu Lys Gln Lys Glu Gln Glu Arg Lys Ile Ile 
625                 630                 635                 640 


Glu Leu Glu Lys Gln Lys Glu Glu Ala Gln Arg Arg Ala Gln Glu Arg 
                645                 650                 655     


Asp Lys Gln Trp Leu Glu His Val Gln Gln Glu Asp Glu His Gln Arg 
            660                 665                 670         


Pro Arg Lys Leu His Glu Glu Glu Lys Leu Lys Arg Glu Glu Ser Val 
        675                 680                 685             


Lys Lys Lys Asp Gly Glu Glu Lys Gly Lys Gln Glu Ala Gln Asp Lys 
    690                 695                 700                 


Leu Gly Arg Leu Phe His Gln His Gln Glu Pro Ala Lys Pro Ala Val 
705                 710                 715                 720 


Gln Ala Pro Trp Ser Thr Ala Glu Lys Gly Pro Leu Thr Ile Ser Ala 
                725                 730                 735     


Gln Glu Asn Val Lys Val Val Tyr Tyr Arg Ala Leu Tyr Pro Phe Glu 
            740                 745                 750         


Ser Arg Ser His Asp Glu Ile Thr Ile Gln Pro Gly Asp Ile Val Met 
        755                 760                 765             


Val Lys Gly Glu Trp Val Asp Glu Ser Gln Thr Gly Glu Pro Gly Trp 
    770                 775                 780                 


Leu Gly Gly Glu Leu Lys Gly Lys Thr Gly Trp Phe Pro Ala Asn Tyr 
785                 790                 795                 800 


Ala Glu Lys Ile Pro Glu Asn Glu Val Pro Ala Pro Val Lys Pro Val 
                805                 810                 815     


Thr Asp Ser Thr Ser Ala Pro Ala Pro Lys Leu Ala Leu Arg Glu Thr 
            820                 825                 830         


Pro Ala Pro Leu Ala Val Thr Ser Ser Glu Pro Ser Thr Thr Pro Asn 
        835                 840                 845             


Asn Trp Ala Asp Phe Ser Ser Thr Trp Pro Thr Ser Thr Asn Glu Lys 
    850                 855                 860                 


Pro Glu Thr Asp Asn Trp Asp Ala Trp Ala Ala Gln Pro Ser Leu Thr 
865                 870                 875                 880 


Val Pro Ser Ala Gly Gln Leu Arg Gln Arg Ser Ala Phe Thr Pro Ala 
                885                 890                 895     


Thr Ala Thr Gly Ser Ser Pro Ser Pro Val Leu Gly Gln Gly Glu Lys 
            900                 905                 910         


Val Glu Gly Leu Gln Ala Gln Ala Leu Tyr Pro Trp Arg Ala Lys Lys 
        915                 920                 925             


Asp Asn His Leu Asn Phe Asn Lys Asn Asp Val Ile Thr Val Leu Glu 
    930                 935                 940                 


Gln Gln Asp Met Trp Trp Phe Gly Glu Val Gln Gly Gln Lys Gly Trp 
945                 950                 955                 960 


Phe Pro Lys Ser Tyr Val Lys Leu Ile Ser Gly Pro Ile Arg Lys Ser 
                965                 970                 975     


Thr Ser Met Asp Ser Gly Ser Ser Glu Ser Pro Ala Ser Leu Lys Arg 
            980                 985                 990         


Val Ala Ser Pro Ala Ala Lys Pro  Val Val Ser Gly Glu  Glu Phe Ile 
        995                 1000                 1005             


Ala Met  Tyr Thr Tyr Glu Ser  Ser Glu Gln Gly Asp  Leu Thr Phe 
    1010                 1015                 1020             


Gln Gln  Gly Asp Val Ile Leu  Val Thr Lys Lys Asp  Gly Asp Trp 
    1025                 1030                 1035             


Trp Thr  Gly Thr Val Gly Asp  Lys Ala Gly Val Phe  Pro Ser Asn 
    1040                 1045                 1050             


Tyr Val  Arg Leu Lys Asp Ser  Glu Gly Ser Gly Thr  Ala Gly Lys 
    1055                 1060                 1065             


Thr Gly  Ser Leu Gly Lys Lys  Pro Glu Ile Ala Gln  Val Ile Ala 
    1070                 1075                 1080             


Ser Tyr  Thr Ala Thr Gly Pro  Glu Gln Leu Thr Leu  Ala Pro Gly 
    1085                 1090                 1095             


Gln Leu  Ile Leu Ile Arg Lys  Lys Asn Pro Gly Gly  Trp Trp Glu 
    1100                 1105                 1110             


Gly Glu  Leu Gln Ala Arg Gly  Lys Lys Arg Gln Ile  Gly Trp Phe 
    1115                 1120                 1125             


Pro Ala  Asn Tyr Val Lys Leu  Leu Ser Pro Gly Thr  Ser Lys Ile 
    1130                 1135                 1140             


Thr Pro  Thr Glu Pro Pro Lys  Ser Thr Ala Leu Ala  Ala Val Cys 
    1145                 1150                 1155             


Gln Val  Ile Gly Met Tyr Asp  Tyr Thr Ala Gln Asn  Asp Asp Glu 
    1160                 1165                 1170             


Leu Ala  Phe Asn Lys Gly Gln  Ile Ile Asn Val Leu  Asn Lys Glu 
    1175                 1180                 1185             


Asp Pro  Asp Trp Trp Lys Gly  Glu Val Asn Gly Gln  Val Gly Leu 
    1190                 1195                 1200             


Phe Pro  Ser Asn Tyr Val Lys  Leu Thr Thr Asp Met  Asp Pro Ser 
    1205                 1210                 1215             


Gln Gln  
    1220 


<210>  351
<211>  1176
<212>  PRT
<213>  Homo sapiens

<400>  351

Met Gly Asp Met Ala Asn Asn Ser Val Ala Tyr Ser Gly Val Lys Asn 
1               5                   10                  15      


Ser Leu Lys Glu Ala Asn His Asp Gly Asp Phe Gly Ile Thr Leu Ala 
            20                  25                  30          


Glu Leu Arg Ala Leu Met Glu Leu Arg Ser Thr Asp Ala Leu Arg Lys 
        35                  40                  45              


Ile Gln Glu Ser Tyr Gly Asp Val Tyr Gly Ile Cys Thr Lys Leu Lys 
    50                  55                  60                  


Thr Ser Pro Asn Glu Gly Leu Ser Gly Asn Pro Ala Asp Leu Glu Arg 
65                  70                  75                  80  


Arg Glu Ala Val Phe Gly Lys Asn Phe Ile Pro Pro Lys Lys Pro Lys 
                85                  90                  95      


Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile 
            100                 105                 110         


Ile Leu Glu Ile Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Gln 
        115                 120                 125             


Pro Pro Glu Gly Asp Asn Ala Leu Cys Gly Glu Val Ser Val Gly Glu 
    130                 135                 140                 


Glu Glu Gly Glu Gly Glu Thr Gly Trp Ile Glu Gly Ala Ala Ile Leu 
145                 150                 155                 160 


Leu Ser Val Val Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser 
                165                 170                 175     


Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu Gln 
            180                 185                 190         


Lys Phe Thr Val Ile Arg Gly Gly Gln Val Ile Gln Ile Pro Val Ala 
        195                 200                 205             


Asp Ile Thr Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu 
    210                 215                 220                 


Pro Ala Asp Gly Ile Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu 
225                 230                 235                 240 


Ser Ser Leu Thr Gly Glu Ser Asp His Val Lys Lys Ser Leu Asp Lys 
                245                 250                 255     


Asp Pro Leu Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg 
            260                 265                 270         


Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Phe 
        275                 280                 285             


Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Glu Lys 
    290                 295                 300                 


Lys Lys Glu Lys Lys Asn Lys Lys Gln Asp Gly Ala Ile Glu Asn Arg 
305                 310                 315                 320 


Asn Lys Ala Lys Ala Gln Asp Gly Ala Ala Met Glu Met Gln Pro Leu 
                325                 330                 335     


Lys Ser Glu Glu Gly Gly Asp Gly Asp Glu Lys Asp Lys Lys Lys Ala 
            340                 345                 350         


Asn Leu Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys 
        355                 360                 365             


Leu Ala Val Gln Ile Gly Lys Ala Gly Leu Leu Met Ser Ala Ile Thr 
    370                 375                 380                 


Val Ile Ile Leu Val Leu Tyr Phe Val Ile Asp Thr Phe Trp Val Gln 
385                 390                 395                 400 


Lys Arg Pro Trp Leu Ala Glu Cys Thr Pro Ile Tyr Ile Gln Tyr Phe 
                405                 410                 415     


Val Lys Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro 
            420                 425                 430         


Glu Gly Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys 
        435                 440                 445             


Lys Met Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu 
    450                 455                 460                 


Thr Met Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu 
465                 470                 475                 480 


Thr Met Asn Arg Met Thr Val Val Gln Ala Tyr Ile Asn Glu Lys His 
                485                 490                 495     


Tyr Lys Lys Val Pro Glu Pro Glu Ala Ile Pro Pro Asn Ile Leu Ser 
            500                 505                 510         


Tyr Leu Val Thr Gly Ile Ser Val Asn Cys Ala Tyr Thr Ser Lys Ile 
        515                 520                 525             


Leu Pro Pro Glu Lys Glu Gly Gly Leu Pro Arg His Val Gly Asn Lys 
    530                 535                 540                 


Thr Glu Cys Ala Leu Leu Gly Leu Leu Leu Asp Leu Lys Arg Asp Tyr 
545                 550                 555                 560 


Gln Asp Val Arg Asn Glu Ile Pro Glu Glu Ala Leu Tyr Lys Val Tyr 
                565                 570                 575     


Thr Phe Asn Ser Val Arg Lys Ser Met Ser Thr Val Leu Lys Asn Ser 
            580                 585                 590         


Asp Gly Ser Tyr Arg Ile Phe Ser Lys Gly Ala Ser Glu Ile Ile Leu 
        595                 600                 605             


Lys Lys Cys Phe Lys Ile Leu Ser Ala Asn Gly Glu Ala Lys Val Phe 
    610                 615                 620                 


Arg Pro Arg Asp Arg Asp Asp Ile Val Lys Thr Val Ile Glu Pro Met 
625                 630                 635                 640 


Ala Ser Glu Gly Leu Arg Thr Ile Cys Leu Ala Phe Arg Asp Phe Pro 
                645                 650                 655     


Ala Gly Glu Pro Glu Pro Glu Trp Asp Asn Glu Asn Asp Ile Val Thr 
            660                 665                 670         


Gly Leu Thr Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro 
        675                 680                 685             


Glu Val Pro Asp Ala Ile Lys Lys Cys Gln Arg Ala Gly Ile Thr Val 
    690                 695                 700                 


Arg Met Val Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Thr 
705                 710                 715                 720 


Lys Cys Gly Ile Leu His Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly 
                725                 730                 735     


Lys Asp Phe Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln 
            740                 745                 750         


Glu Arg Ile Asp Lys Ile Trp Pro Lys Leu Arg Val Leu Ala Arg Ser 
        755                 760                 765             


Ser Pro Thr Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr 
    770                 775                 780                 


Val Ser Asp Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn 
785                 790                 795                 800 


Asp Gly Pro Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile 
                805                 810                 815     


Ala Gly Thr Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp 
            820                 825                 830         


Asp Asn Phe Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val 
        835                 840                 845             


Tyr Asp Ser Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val 
    850                 855                 860                 


Val Ala Val Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser 
865                 870                 875                 880 


Pro Leu Lys Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr 
                885                 890                 895     


Leu Ala Ser Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu 
            900                 905                 910         


Leu Arg Lys Pro Tyr Gly Arg Asn Lys Pro Leu Ile Ser Arg Thr Met 
        915                 920                 925             


Met Lys Asn Ile Leu Gly His Ala Phe Tyr Gln Leu Val Val Val Phe 
    930                 935                 940                 


Thr Leu Leu Phe Ala Gly Glu Lys Phe Phe Asp Ile Asp Ser Gly Arg 
945                 950                 955                 960 


Asn Ala Pro Leu His Ala Pro Pro Ser Glu His Tyr Thr Ile Val Phe 
                965                 970                 975     


Asn Thr Phe Val Leu Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys 
            980                 985                 990         


Ile His Gly Glu Arg Asn Val Phe  Glu Gly Ile Phe Asn  Asn Ala Ile 
        995                 1000                 1005             


Phe Cys  Thr Ile Val Leu Gly  Thr Phe Val Val Gln  Ile Ile Ile 
    1010                 1015                 1020             


Val Gln  Phe Gly Gly Lys Pro  Phe Ser Cys Ser Glu  Leu Ser Ile 
    1025                 1030                 1035             


Glu Gln  Trp Leu Trp Ser Ile  Phe Leu Gly Met Gly  Thr Leu Leu 
    1040                 1045                 1050             


Trp Gly  Gln Leu Ile Ser Thr  Ile Pro Thr Ser Arg  Leu Lys Phe 
    1055                 1060                 1065             


Leu Lys  Glu Ala Gly His Gly  Thr Gln Lys Glu Glu  Ile Pro Glu 
    1070                 1075                 1080             


Glu Glu  Leu Ala Glu Asp Val  Glu Glu Ile Asp His  Ala Glu Arg 
    1085                 1090                 1095             


Glu Leu  Arg Arg Gly Gln Ile  Leu Trp Phe Arg Gly  Leu Asn Arg 
    1100                 1105                 1110             


Ile Gln  Thr Gln Met Asp Val  Val Asn Ala Phe Gln  Ser Gly Ser 
    1115                 1120                 1125             


Ser Ile  Gln Gly Ala Leu Arg  Arg Gln Pro Ser Ile  Ala Ser Gln 
    1130                 1135                 1140             


His His  Asp Val Thr Asn Ile  Ser Thr Pro Thr His  Val Val Phe 
    1145                 1150                 1155             


Ser Ser  Ser Thr Ala Ser Thr  Thr Val Gly Tyr Ser  Ser Gly Glu 
    1160                 1165                 1170             


Cys Ile  Ser 
    1175     


<210>  352
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  352

Met Val Ser Trp Met Ile Ser Arg Ala Val Val Leu Val Phe Gly Met 
1               5                   10                  15      


Leu Tyr Pro Ala Tyr Tyr Ser Tyr Lys Ala Val Lys Thr Lys Asn Val 
            20                  25                  30          


Lys Glu Tyr Val Arg Trp Met Met Tyr Trp Ile Val Phe Ala Leu Tyr 
        35                  40                  45              


Thr Val Ile Glu Thr Val Ala Asp Gln Thr Val Ala Trp Phe Pro Leu 
    50                  55                  60                  


Tyr Tyr Glu Leu Lys Ile Ala Phe Val Ile Trp Leu Leu Ser Pro Tyr 
65                  70                  75                  80  


Thr Lys Gly Ala Ser Leu Ile Tyr Arg Lys Phe Leu His Pro Leu Leu 
                85                  90                  95      


Ser Ser Lys Glu Arg Glu Ile Asp Asp Tyr Ile Val Gln Ala Lys Glu 
            100                 105                 110         


Arg Gly Tyr Glu Thr Met Val Asn Phe Gly Arg Gln Gly Leu Asn Leu 
        115                 120                 125             


Ala Ala Thr Ala Ala Val Thr Ala Ala Val Lys Ser Gln Gly Ala Ile 
    130                 135                 140                 


Thr Glu Arg Leu Arg Ser Phe Ser Met His Asp Leu Thr Thr Ile Gln 
145                 150                 155                 160 


Gly Asp Glu Pro Val Gly Gln Arg Pro Tyr Gln Pro Leu Pro Glu Ala 
                165                 170                 175     


Lys Lys Lys Ser Lys Pro Ala Pro Ser Glu Ser Ala Gly Tyr Gly Ile 
            180                 185                 190         


Pro Leu Lys Asp Gly Asp Glu Lys Thr Asp Glu Glu Ala Glu Gly Pro 
        195                 200                 205             


Tyr Ser Asp Asn Glu Met Leu Thr His Lys Gly Leu Arg Arg Ser Gln 
    210                 215                 220                 


Ser Met Lys Ser Val Lys Thr Thr Lys Gly Arg Lys Glu Val Arg Tyr 
225                 230                 235                 240 


Gly Ser Leu Lys Tyr Lys Val Lys Lys Arg Pro Gln Val Tyr Phe 
                245                 250                 255 


<210>  353
<211>  1243
<212>  PRT
<213>  Homo sapiens

<400>  353

Met Gly Asp Met Thr Asn Ser Asp Phe Tyr Ser Lys Asn Gln Arg Asn 
1               5                   10                  15      


Glu Ser Ser His Gly Gly Glu Phe Gly Cys Thr Met Glu Glu Leu Arg 
            20                  25                  30          


Ser Leu Met Glu Leu Arg Gly Thr Glu Ala Val Val Lys Ile Lys Glu 
        35                  40                  45              


Thr Tyr Gly Asp Thr Glu Ala Ile Cys Arg Arg Leu Lys Thr Ser Pro 
    50                  55                  60                  


Val Glu Gly Leu Pro Gly Thr Ala Pro Asp Leu Glu Lys Arg Lys Gln 
65                  70                  75                  80  


Ile Phe Gly Gln Asn Phe Ile Pro Pro Lys Lys Pro Lys Thr Phe Leu 
                85                  90                  95      


Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile Ile Leu Glu 
            100                 105                 110         


Ile Ala Ala Ile Ile Ser Leu Gly Leu Ser Phe Tyr His Pro Pro Gly 
        115                 120                 125             


Glu Gly Asn Glu Gly Cys Ala Thr Ala Gln Gly Gly Ala Glu Asp Glu 
    130                 135                 140                 


Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile Leu Leu Ser 
145                 150                 155                 160 


Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser Lys Glu 
                165                 170                 175     


Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu Gln Lys Phe 
            180                 185                 190         


Thr Val Val Arg Ala Gly Gln Val Val Gln Ile Pro Val Ala Glu Ile 
        195                 200                 205             


Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu Pro Ala 
    210                 215                 220                 


Asp Gly Leu Phe Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu Ser Ser 
225                 230                 235                 240 


Leu Thr Gly Glu Ser Asp Gln Val Arg Lys Ser Val Asp Lys Asp Pro 
                245                 250                 255     


Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg Met Leu 
            260                 265                 270         


Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Phe Thr Leu 
        275                 280                 285             


Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys Lys Gly Val 
    290                 295                 300                 


Lys Lys Gly Asp Gly Leu Gln Leu Pro Ala Ala Asp Gly Ala Ala Ala 
305                 310                 315                 320 


Ser Asn Ala Ala Asp Ser Ala Asn Ala Ser Leu Val Asn Gly Lys Met 
                325                 330                 335     


Gln Asp Gly Asn Val Asp Ala Ser Gln Ser Lys Ala Lys Gln Gln Asp 
            340                 345                 350         


Gly Ala Ala Ala Met Glu Met Gln Pro Leu Lys Ser Ala Glu Gly Gly 
        355                 360                 365             


Asp Ala Asp Asp Arg Lys Lys Ala Ser Met His Lys Lys Glu Lys Ser 
    370                 375                 380                 


Val Leu Gln Gly Lys Leu Thr Lys Leu Ala Val Gln Ile Gly Lys Ala 
385                 390                 395                 400 


Gly Leu Val Met Ser Ala Ile Thr Val Ile Ile Leu Val Leu Tyr Phe 
                405                 410                 415     


Thr Val Asp Thr Phe Val Val Asn Lys Lys Pro Trp Leu Pro Glu Cys 
            420                 425                 430         


Thr Pro Val Tyr Val Gln Tyr Phe Val Lys Phe Phe Ile Ile Gly Val 
        435                 440                 445             


Thr Val Leu Val Val Ala Val Pro Glu Gly Leu Pro Leu Ala Val Thr 
    450                 455                 460                 


Ile Ser Leu Ala Tyr Ser Val Lys Lys Met Met Lys Asp Asn Asn Leu 
465                 470                 475                 480 


Val Arg His Leu Asp Ala Cys Glu Thr Met Gly Asn Ala Thr Ala Ile 
                485                 490                 495     


Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr Asn Arg Met Thr Val Val 
            500                 505                 510         


Gln Ala Tyr Val Gly Asp Val His Tyr Lys Glu Ile Pro Asp Pro Ser 
        515                 520                 525             


Ser Ile Asn Thr Lys Thr Met Glu Leu Leu Ile Asn Ala Ile Ala Ile 
    530                 535                 540                 


Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro Pro Glu Lys Glu Gly Ala 
545                 550                 555                 560 


Leu Pro Arg Gln Val Gly Asn Lys Thr Glu Cys Gly Leu Leu Gly Phe 
                565                 570                 575     


Val Leu Asp Leu Lys Gln Asp Tyr Glu Pro Val Arg Ser Gln Met Pro 
            580                 585                 590         


Glu Glu Lys Leu Tyr Lys Val Tyr Thr Phe Asn Ser Val Arg Lys Ser 
        595                 600                 605             


Met Ser Thr Val Ile Lys Leu Pro Asp Glu Ser Phe Arg Met Tyr Ser 
    610                 615                 620                 


Lys Gly Ala Ser Glu Ile Val Leu Lys Lys Cys Cys Lys Ile Leu Asn 
625                 630                 635                 640 


Gly Ala Gly Glu Pro Arg Val Phe Arg Pro Arg Asp Arg Asp Glu Met 
                645                 650                 655     


Val Lys Lys Val Ile Glu Pro Met Ala Cys Asp Gly Leu Arg Thr Ile 
            660                 665                 670         


Cys Val Ala Tyr Arg Asp Phe Pro Ser Ser Pro Glu Pro Asp Trp Asp 
        675                 680                 685             


Asn Glu Asn Asp Ile Leu Asn Glu Leu Thr Cys Ile Cys Val Val Gly 
    690                 695                 700                 


Ile Glu Asp Pro Val Arg Pro Glu Val Pro Glu Ala Ile Arg Lys Cys 
705                 710                 715                 720 


Gln Arg Ala Gly Ile Thr Val Arg Met Val Thr Gly Asp Asn Ile Asn 
                725                 730                 735     


Thr Ala Arg Ala Ile Ala Ile Lys Cys Gly Ile Ile His Pro Gly Glu 
            740                 745                 750         


Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe Asn Arg Arg Ile Arg Asn 
        755                 760                 765             


Glu Lys Gly Glu Ile Glu Gln Glu Arg Ile Asp Lys Ile Trp Pro Lys 
    770                 775                 780                 


Leu Arg Val Leu Ala Arg Ser Ser Pro Thr Asp Lys His Thr Leu Val 
785                 790                 795                 800 


Lys Gly Ile Ile Asp Ser Thr His Thr Glu Gln Arg Gln Val Val Ala 
                805                 810                 815     


Val Thr Gly Asp Gly Thr Asn Asp Gly Pro Ala Leu Lys Lys Ala Asp 
            820                 825                 830         


Val Gly Phe Ala Met Gly Ile Ala Gly Thr Asp Val Ala Lys Glu Ala 
        835                 840                 845             


Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe Ser Ser Ile Val Lys Ala 
    850                 855                 860                 


Val Met Trp Gly Arg Asn Val Tyr Asp Ser Ile Ser Lys Phe Leu Gln 
865                 870                 875                 880 


Phe Gln Leu Thr Val Asn Val Val Ala Val Ile Val Ala Phe Thr Gly 
                885                 890                 895     


Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys Ala Val Gln Met Leu Trp 
            900                 905                 910         


Val Asn Leu Ile Met Asp Thr Phe Ala Ser Leu Ala Leu Ala Thr Glu 
        915                 920                 925             


Pro Pro Thr Glu Thr Leu Leu Leu Arg Lys Pro Tyr Gly Arg Asn Lys 
    930                 935                 940                 


Pro Leu Ile Ser Arg Thr Met Met Lys Asn Ile Leu Gly His Ala Val 
945                 950                 955                 960 


Tyr Gln Leu Ala Leu Ile Phe Thr Leu Leu Phe Val Gly Glu Lys Met 
                965                 970                 975     


Phe Gln Ile Asp Ser Gly Arg Asn Ala Pro Leu His Ser Pro Pro Ser 
            980                 985                 990         


Glu His Tyr Thr Ile Ile Phe Asn  Thr Phe Val Met Met  Gln Leu Phe 
        995                 1000                 1005             


Asn Glu  Ile Asn Ala Arg Lys  Ile His Gly Glu Arg  Asn Val Phe 
    1010                 1015                 1020             


Asp Gly  Ile Phe Arg Asn Pro  Ile Phe Cys Thr Ile  Val Leu Gly 
    1025                 1030                 1035             


Thr Phe  Ala Ile Gln Ile Val  Ile Val Gln Phe Gly  Gly Lys Pro 
    1040                 1045                 1050             


Phe Ser  Cys Ser Pro Leu Gln  Leu Asp Gln Trp Met  Trp Cys Ile 
    1055                 1060                 1065             


Phe Ile  Gly Leu Gly Glu Leu  Val Trp Gly Gln Val  Ile Ala Thr 
    1070                 1075                 1080             


Ile Pro  Thr Ser Arg Leu Lys  Phe Leu Lys Glu Ala  Gly Arg Leu 
    1085                 1090                 1095             


Thr Gln  Lys Glu Glu Ile Pro  Glu Glu Glu Leu Asn  Glu Asp Val 
    1100                 1105                 1110             


Glu Glu  Ile Asp His Ala Glu  Arg Glu Leu Arg Arg  Gly Gln Ile 
    1115                 1120                 1125             


Leu Trp  Phe Arg Gly Leu Asn  Arg Ile Gln Thr Gln  Ile Arg Val 
    1130                 1135                 1140             


Val Lys  Ala Phe Arg Ser Ser  Leu Tyr Glu Gly Leu  Glu Lys Pro 
    1145                 1150                 1155             


Glu Ser  Arg Thr Ser Ile His  Asn Phe Met Ala His  Pro Glu Phe 
    1160                 1165                 1170             


Arg Ile  Glu Asp Ser Gln Pro  His Ile Pro Leu Ile  Asp Asp Thr 
    1175                 1180                 1185             


Asp Leu  Glu Glu Asp Ala Ala  Leu Lys Gln Asn Ser  Ser Pro Pro 
    1190                 1195                 1200             


Ser Ser  Leu Asn Lys Asn Asn  Ser Ala Ile Asp Ser  Gly Ile Asn 
    1205                 1210                 1215             


Leu Thr  Thr Asp Thr Ser Lys  Ser Ala Thr Ser Ser  Ser Pro Gly 
    1220                 1225                 1230             


Ser Pro  Ile His Ser Leu Glu  Thr Ser Leu 
    1235                 1240             


<210>  354
<211>  1220
<212>  PRT
<213>  Homo sapiens

<400>  354

Met Gly Asp Met Ala Asn Ser Ser Ile Glu Phe His Pro Lys Pro Gln 
1               5                   10                  15      


Gln Gln Arg Asp Val Pro Gln Ala Gly Gly Phe Gly Cys Thr Leu Ala 
            20                  25                  30          


Glu Leu Arg Thr Leu Met Glu Leu Arg Gly Ala Glu Ala Leu Gln Lys 
        35                  40                  45              


Ile Glu Glu Ala Tyr Gly Asp Val Ser Gly Leu Cys Arg Arg Leu Lys 
    50                  55                  60                  


Thr Ser Pro Thr Glu Gly Leu Ala Asp Asn Thr Asn Asp Leu Glu Lys 
65                  70                  75                  80  


Arg Arg Gln Ile Tyr Gly Gln Asn Phe Ile Pro Pro Lys Gln Pro Lys 
                85                  90                  95      


Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile 
            100                 105                 110         


Ile Leu Glu Val Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Ala 
        115                 120                 125             


Pro Pro Gly Glu Glu Ser Glu Ala Cys Gly Asn Val Ser Gly Gly Ala 
    130                 135                 140                 


Glu Asp Glu Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile 
145                 150                 155                 160 


Leu Leu Ser Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp 
                165                 170                 175     


Ser Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu 
            180                 185                 190         


Gln Lys Phe Thr Val Ile Arg Asn Gly Gln Leu Leu Gln Val Pro Val 
        195                 200                 205             


Ala Ala Leu Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu 
    210                 215                 220                 


Leu Pro Ala Asp Gly Val Leu Ile Gln Ala Asn Asp Leu Lys Ile Asp 
225                 230                 235                 240 


Glu Ser Ser Leu Thr Gly Glu Ser Asp His Val Arg Lys Ser Ala Asp 
                245                 250                 255     


Lys Asp Pro Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly 
            260                 265                 270         


Arg Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile 
        275                 280                 285             


Phe Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys 
    290                 295                 300                 


Lys Gly Lys Gln Gln Asp Gly Ala Met Glu Ser Ser Gln Thr Lys Ala 
305                 310                 315                 320 


Lys Lys Gln Asp Gly Ala Val Ala Met Glu Met Gln Pro Leu Lys Ser 
                325                 330                 335     


Ala Glu Gly Gly Glu Met Glu Glu Arg Glu Lys Lys Lys Ala Asn Ala 
            340                 345                 350         


Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys Leu Ala 
        355                 360                 365             


Val Gln Ile Gly Lys Ala Gly Leu Val Met Ser Ala Ile Thr Val Ile 
    370                 375                 380                 


Ile Leu Val Leu Tyr Phe Val Ile Glu Thr Phe Val Val Glu Gly Arg 
385                 390                 395                 400 


Thr Trp Leu Ala Glu Cys Thr Pro Val Tyr Val Gln Tyr Phe Val Lys 
                405                 410                 415     


Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro Glu Gly 
            420                 425                 430         


Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys Lys Met 
        435                 440                 445             


Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu Thr Met 
    450                 455                 460                 


Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr 
465                 470                 475                 480 


Asn Arg Met Thr Val Val Gln Ser Tyr Leu Gly Asp Thr His Tyr Lys 
                485                 490                 495     


Glu Ile Pro Ala Pro Ser Ala Leu Thr Pro Lys Ile Leu Asp Leu Leu 
            500                 505                 510         


Val His Ala Ile Ser Ile Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro 
        515                 520                 525             


Pro Glu Lys Glu Gly Ala Leu Pro Arg Gln Val Gly Asn Lys Thr Glu 
    530                 535                 540                 


Cys Ala Leu Leu Gly Phe Val Leu Asp Leu Lys Arg Asp Phe Gln Pro 
545                 550                 555                 560 


Val Arg Glu Gln Ile Pro Glu Asp Lys Leu Tyr Lys Val Tyr Thr Phe 
                565                 570                 575     


Asn Ser Val Arg Lys Ser Met Ser Thr Val Ile Arg Met Pro Asp Gly 
            580                 585                 590         


Gly Phe Arg Leu Phe Ser Lys Gly Ala Ser Glu Ile Leu Leu Lys Lys 
        595                 600                 605             


Cys Thr Asn Ile Leu Asn Ser Asn Gly Glu Leu Arg Gly Phe Arg Pro 
    610                 615                 620                 


Arg Asp Arg Asp Asp Met Val Arg Lys Ile Ile Glu Pro Met Ala Cys 
625                 630                 635                 640 


Asp Gly Leu Arg Thr Ile Cys Ile Ala Tyr Arg Asp Phe Ser Ala Gly 
                645                 650                 655     


Gln Glu Pro Asp Trp Asp Asn Glu Asn Glu Val Val Gly Asp Leu Thr 
            660                 665                 670         


Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro Glu Val Pro 
        675                 680                 685             


Glu Ala Ile Arg Lys Cys Gln Arg Ala Gly Ile Thr Val Arg Met Val 
    690                 695                 700                 


Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Ala Lys Cys Gly 
705                 710                 715                 720 


Ile Ile Gln Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe 
                725                 730                 735     


Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln Glu Arg Leu 
            740                 745                 750         


Asp Lys Val Trp Pro Lys Leu Arg Val Leu Ala Arg Ser Ser Pro Thr 
        755                 760                 765             


Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr Thr Gly Glu 
    770                 775                 780                 


Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn Asp Gly Pro 
785                 790                 795                 800 


Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile Ala Gly Thr 
                805                 810                 815     


Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe 
            820                 825                 830         


Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val Tyr Asp Ser 
        835                 840                 845             


Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val Val Ala Val 
    850                 855                 860                 


Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys 
865                 870                 875                 880 


Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr Phe Ala Ser 
                885                 890                 895     


Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu Leu Arg Lys 
            900                 905                 910         


Pro Tyr Gly Arg Asp Lys Pro Leu Ile Ser Arg Thr Met Met Lys Asn 
        915                 920                 925             


Ile Leu Gly His Ala Val Tyr Gln Leu Ala Ile Ile Phe Thr Leu Leu 
    930                 935                 940                 


Phe Val Gly Glu Leu Phe Phe Asp Ile Asp Ser Gly Arg Asn Ala Pro 
945                 950                 955                 960 


Leu His Ser Pro Pro Ser Glu His Tyr Thr Ile Ile Phe Asn Thr Phe 
                965                 970                 975     


Val Met Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys Ile His Gly 
            980                 985                 990         


Glu Arg Asn Val Phe Asp Gly Ile  Phe Ser Asn Pro Ile  Phe Cys Thr 
        995                 1000                 1005             


Ile Val  Leu Gly Thr Phe Gly  Ile Gln Ile Val Ile  Val Gln Phe 
    1010                 1015                 1020             


Gly Gly  Lys Pro Phe Ser Cys  Ser Pro Leu Ser Thr  Glu Gln Trp 
    1025                 1030                 1035             


Leu Trp  Cys Leu Phe Val Gly  Val Gly Glu Leu Val  Trp Gly Gln 
    1040                 1045                 1050             


Val Ile  Ala Thr Ile Pro Thr  Ser Gln Leu Lys Cys  Leu Lys Glu 
    1055                 1060                 1065             


Ala Gly  His Gly Pro Gly Lys  Asp Glu Met Thr Asp  Glu Glu Leu 
    1070                 1075                 1080             


Ala Glu  Gly Glu Glu Glu Ile  Asp His Ala Glu Arg  Glu Leu Arg 
    1085                 1090                 1095             


Arg Gly  Gln Ile Leu Trp Phe  Arg Gly Leu Asn Arg  Ile Gln Thr 
    1100                 1105                 1110             


Gln Ile  Arg Val Val Lys Ala  Phe Arg Ser Ser Leu  Tyr Glu Gly 
    1115                 1120                 1125             


Leu Glu  Lys Pro Glu Ser Lys  Thr Ser Ile His Asn  Phe Met Ala 
    1130                 1135                 1140             


Thr Pro  Glu Phe Leu Ile Asn  Asp Tyr Thr His Asn  Ile Pro Leu 
    1145                 1150                 1155             


Ile Asp  Asp Thr Asp Val Asp  Glu Asn Glu Glu Arg  Leu Arg Ala 
    1160                 1165                 1170             


Pro Pro  Pro Pro Ser Pro Asn  Gln Asn Asn Asn Ala  Ile Asp Ser 
    1175                 1180                 1185             


Gly Ile  Tyr Leu Thr Thr His  Val Thr Lys Ser Ala  Thr Ser Ser 
    1190                 1195                 1200             


Val Phe  Ser Ser Ser Pro Gly  Ser Pro Leu His Ser  Val Glu Thr 
    1205                 1210                 1215             


Ser Leu  
    1220 


<210>  355
<211>  699
<212>  PRT
<213>  Homo sapiens

<400>  355

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Ser Thr 
    210                 215                 220                 


Ser Ser Asn Thr Ile Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu 
225                 230                 235                 240 


Asp Glu Arg Asp Arg His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp 
                245                 250                 255     


Asp Glu Asp Phe Ile Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe 
            260                 265                 270         


Asp His Thr Lys Gln Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His 
        275                 280                 285             


Ser Asn Pro Glu Val Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val 
    290                 295                 300                 


Asp Arg Asn Gly Thr Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala 
305                 310                 315                 320 


His Pro Pro Leu Ile His His Glu His His Glu Glu Glu Glu Thr Pro 
                325                 330                 335     


His Ser Thr Ser Thr Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu 
            340                 345                 350         


Thr Ala Thr Gln Lys Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly 
        355                 360                 365             


Tyr Arg Gln Thr Pro Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala 
    370                 375                 380                 


Ala Ala Ser Ala His Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro 
385                 390                 395                 400 


Ser Pro Glu Asp Ser Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His 
                405                 410                 415     


Pro Met Gly Arg Gly His Gln Ala Gly Arg Arg Met Asp Met Asp Ser 
            420                 425                 430         


Ser His Ser Ile Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu 
        435                 440                 445             


Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln 
    450                 455                 460                 


Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp 
465                 470                 475                 480 


Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp 
                485                 490                 495     


Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr 
            500                 505                 510         


Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg 
        515                 520                 525             


Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr 
    530                 535                 540                 


Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser 
545                 550                 555                 560 


Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His 
                565                 570                 575     


Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala 
            580                 585                 590         


Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu 
        595                 600                 605             


Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys 
    610                 615                 620                 


Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val 
625                 630                 635                 640 


Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu 
                645                 650                 655     


Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys 
            660                 665                 670         


Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg 
        675                 680                 685             


Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 
    690                 695                 


<210>  356
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  356

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Asn Met 
    210                 215                 220                 


Asp Ser Ser His Ser Ile Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr 
225                 230                 235                 240 


Gly Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr 
                245                 250                 255     


Gln Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu 
            260                 265                 270         


Glu Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg 
        275                 280                 285             


Asn Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser 
    290                 295                 300                 


Thr Thr Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu 
305                 310                 315                 320 


Ser Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly 
                325                 330                 335     


Val Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser 
            340                 345                 350         


Leu Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr 
        355                 360                 365             


Thr His Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly 
    370                 375                 380                 


Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu 
385                 390                 395                 400 


Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala 
                405                 410                 415     


Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys 
            420                 425                 430         


Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser 
        435                 440                 445             


Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val 
    450                 455                 460                 


Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu 
465                 470                 475                 480 


Thr Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 
                485                 490             


<210>  357
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  357

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg Asp 
    210                 215                 220                 


Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser 
225                 230                 235                 240 


Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr 
                245                 250                 255     


Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile 
            260                 265                 270         


Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala 
        275                 280                 285             


Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn 
    290                 295                 300                 


Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly 
305                 310                 315                 320 


Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser 
                325                 330                 335     


Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu 
            340                 345                 350         


Gln Asn Val Asp Met Lys Ile Gly Val 
        355                 360     


<210>  358
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  358

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Ser Leu His 
65                  70                  75                  80  


Cys Ser Gln Gln Ser Lys Lys Val Trp Ala Glu Glu Lys Ala Ser Asp 
                85                  90                  95      


Gln Gln Trp Gln Trp Ser Cys Gly Gly Gln Lys Ala Lys Trp Thr Gln 
            100                 105                 110         


Arg Arg Gly Gln Gln Val Ser Gly Asn Gly Ala Phe Gly Glu Gln Gly 
        115                 120                 125             


Val Val Arg Asn Ser Arg Pro Val Tyr Asp Ser 
    130                 135                 


<210>  359
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  359

Met Met Asp Lys Phe Arg Met Ile Phe Gln Phe Leu Gln Ser Asn Gln 
1               5                   10                  15      


Glu Ser Phe Met Asn Gly Ile Cys Gly Ile Met Ala Leu Ala Ser Ala 
            20                  25                  30          


Gln Met Tyr Ser Ala Phe Asp Phe Asn Cys Pro Cys Leu Pro Gly Tyr 
        35                  40                  45              


Asn Ala Ala Tyr Ser Ala Gly Ile Leu Leu Ala Pro Pro Leu Val Leu 
    50                  55                  60                  


Phe Leu Leu Gly Leu Val Met Asn Asn Asn Val Ser Met Leu Ala Glu 
65                  70                  75                  80  


Glu Trp Lys Arg Pro Leu Gly Arg Arg Ala Lys Asp Pro Ala Val Leu 
                85                  90                  95      


Arg Tyr Met Phe Cys Ser Met Ala Gln Arg Ala Leu Ile Ala Pro Val 
            100                 105                 110         


Val Trp Val Ala Val Thr Leu Leu Asp Gly Lys Cys Phe Leu Cys Ala 
        115                 120                 125             


Phe Cys Thr Ala Val Pro Val Ser Ala Leu Gly Asn Gly Ser Leu Ala 
    130                 135                 140                 


Pro Gly Leu Pro Ala Pro Glu Leu Ala Arg Leu Leu Ala Arg Val Pro 
145                 150                 155                 160 


Cys Pro Glu Ile Tyr Asp Gly Asp Trp Leu Leu Ala Arg Glu Val Ala 
                165                 170                 175     


Val Arg Tyr Leu Arg Cys Ile Ser Gln Ala Leu Gly Trp Ser Phe Val 
            180                 185                 190         


Leu Leu Thr Thr Leu Leu Ala Phe Val Val Arg Ser Val Arg Pro Cys 
        195                 200                 205             


Phe Thr Gln Ala Ala Phe Leu Lys Ser Lys Tyr Trp Ser His Tyr Ile 
    210                 215                 220                 


Asp Ile Glu Arg Lys Leu Phe Asp Glu Thr Cys Thr Glu His Ala Lys 
225                 230                 235                 240 


Ala Phe Ala Lys Val Cys Ile Gln Gln Phe Phe Glu Ala Met Asn His 
                245                 250                 255     


Asp Leu Glu Leu Gly His Thr His Gly Thr Leu Ala Thr Ala Pro Ala 
            260                 265                 270         


Ser Ala Ala Ala Pro Thr Thr Pro Asp Gly Ala Glu Glu Glu Arg Glu 
        275                 280                 285             


Lys Leu Arg Gly Ile Thr Asp Gln Gly Thr Met Asn Arg Leu Leu Thr 
    290                 295                 300                 


Ser Trp His Lys Cys Lys Pro Pro Leu Arg Leu Gly Gln Glu Glu Pro 
305                 310                 315                 320 


Pro Leu Met Gly Asn Gly Trp Ala Gly Gly Gly Pro Arg Pro Pro Arg 
                325                 330                 335     


Lys Glu Val Ala Thr Tyr Phe Ser Lys Val 
            340                 345     


<210>  360
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  360

Met Lys Leu Cys Val Thr Val Leu Ser Leu Leu Val Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Leu Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Thr Ser Ser Leu Cys Ser Gln Pro Ala Val Val 
    50                  55                  60                  


Phe Gln Thr Lys Arg Gly Lys Gln Val Cys Ala Asp Pro Ser Glu Ser 
65                  70                  75                  80  


Trp Val Gln Glu Tyr Val Tyr Asp Leu Glu Leu Asn 
                85                  90          


<210>  361
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  361

Met Cys Arg Cys Pro Pro Glu His His Asp Gly Arg Met Thr Ser Ala 
1               5                   10                  15      


Glu Val Gly Ala Ala Ala Gly Gly Ala Gln Ala Ala Gly Pro Pro Glu 
            20                  25                  30          


Trp Pro Pro Gly Ser Pro Gln Ala Leu Arg Gln Pro Gly Arg Ala Arg 
        35                  40                  45              


Val Ala Met Ala Ala Leu Val Trp Leu Leu Ala Gly Ala Ser Met Ser 
    50                  55                  60                  


Ser Leu Asn Lys Trp Ile Phe Thr Val His Gly Phe Gly Arg Pro Leu 
65                  70                  75                  80  


Leu Leu Ser Ala Leu His Met Leu Val Ala Ala Leu Ala Cys His Arg 
                85                  90                  95      


Gly Ala Arg Arg Pro Met Pro Gly Gly Thr Arg Cys Arg Val Leu Leu 
            100                 105                 110         


Leu Ser Leu Thr Phe Gly Thr Ser Met Ala Cys Gly Asn Val Gly Leu 
        115                 120                 125             


Arg Ala Val Pro Leu Asp Leu Ala Gln Leu Val Thr Thr Thr Thr Pro 
    130                 135                 140                 


Leu Phe Thr Leu Ala Leu Ser Ala Leu Leu Leu Gly Arg Arg His His 
145                 150                 155                 160 


Pro Leu Gln Leu Ala Ala Met Gly Pro Leu Cys Leu Gly Ala Ala Cys 
                165                 170                 175     


Ser Leu Ala Gly Glu Phe Arg Thr Pro Pro Thr Gly Cys Gly Phe Leu 
            180                 185                 190         


Leu Ala Ala Thr Cys Leu Arg Gly Leu Lys Ser Val Gln Gln Ser Ala 
        195                 200                 205             


Leu Leu Gln Glu Glu Arg Leu Asp Ala Val Thr Leu Leu Tyr Ala Thr 
    210                 215                 220                 


Ser Leu Pro Ser Phe Cys Leu Leu Ala Gly Ala Ala Leu Val Leu Glu 
225                 230                 235                 240 


Ala Gly Val Ala Pro Pro Pro Thr Ala Gly Asp Ser Arg Leu Trp Ala 
                245                 250                 255     


Cys Ile Leu Leu Ser Cys Leu Leu Ser Val Leu Tyr Asn Leu Ala Ser 
            260                 265                 270         


Phe Ser Leu Leu Ala Leu Thr Ser Ala Leu Thr Val His Val Leu Gly 
        275                 280                 285             


Asn Leu Thr Val Val Gly Asn Leu Ile Leu Ser Arg Leu Leu Phe Gly 
    290                 295                 300                 


Ser Arg Leu Ser Ala Leu Ser Tyr Val Gly Ile Ala Leu Thr Leu Ser 
305                 310                 315                 320 


Gly Met Phe Leu Tyr His Asn Cys Glu Phe Val Ala Ser Trp Ala Ala 
                325                 330                 335     


Arg Arg Gly Leu Trp Arg Arg Asp Gln Pro Ser Lys Gly Leu 
            340                 345                 350 


<210>  362
<211>  492
<212>  PRT
<213>  Homo sapiens

<400>  362

Met Val Ile Leu Leu Leu Gln His Gly Ala Asp Pro Thr Leu Ile Asp 
1               5                   10                  15      


Gly Glu Gly Phe Ser Ser Ile His Leu Ala Val Leu Phe Gln His Met 
            20                  25                  30          


Pro Ile Ile Ala Tyr Leu Ile Ser Lys Gly Gln Ser Val Asn Met Thr 
        35                  40                  45              


Asp Val Asn Gly Gln Thr Pro Leu Met Leu Ser Ala His Lys Val Ile 
    50                  55                  60                  


Gly Pro Glu Pro Thr Gly Phe Leu Leu Lys Phe Asn Pro Ser Leu Asn 
65                  70                  75                  80  


Val Val Asp Lys Ile His Gln Asn Thr Pro Leu His Trp Ala Val Ala 
                85                  90                  95      


Ala Gly Asn Val Asn Ala Val Asp Lys Leu Leu Glu Ala Gly Ser Ser 
            100                 105                 110         


Leu Asp Ile Gln Asn Val Lys Gly Glu Thr Pro Leu Asp Met Ala Leu 
        115                 120                 125             


Gln Asn Lys Asn Gln Leu Ile Ile His Met Leu Lys Thr Glu Ala Lys 
    130                 135                 140                 


Met Arg Ala Asn Gln Lys Phe Arg Leu Trp Arg Trp Leu Gln Lys Cys 
145                 150                 155                 160 


Glu Leu Phe Leu Leu Leu Met Leu Ser Val Ile Thr Met Trp Ala Ile 
                165                 170                 175     


Gly Tyr Ile Leu Asp Phe Asn Ser Asp Ser Trp Leu Leu Lys Gly Cys 
            180                 185                 190         


Leu Leu Val Thr Leu Phe Phe Leu Thr Ser Leu Phe Pro Arg Phe Leu 
        195                 200                 205             


Val Gly Tyr Lys Asn Leu Val Tyr Leu Pro Thr Ala Phe Leu Leu Ser 
    210                 215                 220                 


Ser Val Phe Trp Ile Phe Met Thr Trp Phe Ile Leu Phe Phe Pro Asp 
225                 230                 235                 240 


Leu Ala Gly Ala Pro Phe Tyr Phe Ser Phe Ile Phe Ser Ile Val Ala 
                245                 250                 255     


Phe Leu Tyr Phe Phe Tyr Lys Thr Trp Ala Thr Asp Pro Gly Phe Thr 
            260                 265                 270         


Lys Ala Ser Glu Glu Glu Lys Lys Val Asn Ile Ile Thr Leu Ala Glu 
        275                 280                 285             


Thr Gly Ser Leu Asp Phe Arg Thr Phe Cys Thr Ser Cys Leu Ile Arg 
    290                 295                 300                 


Lys Pro Leu Arg Ser Leu His Cys His Val Cys Asn Cys Cys Val Ala 
305                 310                 315                 320 


Arg Tyr Asp Gln His Cys Leu Trp Thr Gly Arg Cys Ile Gly Phe Gly 
                325                 330                 335     


Asn His His Tyr Tyr Ile Phe Phe Leu Phe Phe Leu Ser Met Val Cys 
            340                 345                 350         


Gly Trp Ile Ile Tyr Gly Ser Phe Ile Tyr Leu Ser Ser His Cys Ala 
        355                 360                 365             


Thr Thr Phe Lys Glu Asp Gly Leu Trp Thr Tyr Leu Asn Gln Ile Val 
    370                 375                 380                 


Ala Cys Ser Pro Trp Val Leu Tyr Ile Leu Met Leu Ala Thr Phe His 
385                 390                 395                 400 


Phe Ser Trp Ser Thr Phe Leu Leu Leu Asn Gln Leu Phe Gln Ile Ala 
                405                 410                 415     


Phe Leu Gly Leu Thr Ser His Glu Arg Ile Ser Leu Gln Lys Gln Ser 
            420                 425                 430         


Lys His Met Lys Gln Thr Leu Ser Leu Arg Lys Thr Pro Tyr Asn Leu 
        435                 440                 445             


Gly Phe Met Gln Asn Leu Ala Asp Phe Phe Gln Cys Gly Cys Phe Gly 
    450                 455                 460                 


Leu Val Lys Pro Cys Val Val Asp Trp Thr Ser Gln Tyr Thr Met Val 
465                 470                 475                 480 


Phe His Pro Ala Arg Glu Lys Val Leu Arg Ser Val 
                485                 490         


<210>  363
<211>  888
<212>  PRT
<213>  Homo sapiens

<400>  363

Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Thr 
1               5                   10                  15      


Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile 
            100                 105                 110         


Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
        115                 120                 125             


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
    130                 135                 140                 


Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly Asp Thr 
145                 150                 155                 160 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
                165                 170                 175     


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly Glu Thr 
            180                 185                 190         


Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr Asn Gly 
        195                 200                 205             


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu Val Arg 
    210                 215                 220                 


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn Ser Glu 
225                 230                 235                 240 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Thr 
                245                 250                 255     


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
            260                 265                 270         


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
        275                 280                 285             


Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala 
    290                 295                 300                 


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu Ala Leu 
305                 310                 315                 320 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
                325                 330                 335     


Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Thr 
            340                 345                 350         


Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Phe Thr Ser 
        355                 360                 365             


Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln Phe Gly 
    370                 375                 380                 


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
385                 390                 395                 400 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
                405                 410                 415     


Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu Ile Ala 
            420                 425                 430         


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
        435                 440                 445             


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
    450                 455                 460                 


Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
465                 470                 475                 480 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Gln Ser Lys 
                485                 490                 495     


Gly Gln Thr Leu Thr Leu Thr Gln Gln Gln Arg Asp Val Tyr Gln Gln 
            500                 505                 510         


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
        515                 520                 525             


Ser Gly Pro Glu Leu Gly Gln Leu Thr Phe Leu Gly Leu Val Gly Ile 
    530                 535                 540                 


Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr Leu Ile 
545                 550                 555                 560 


Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln Glu Thr 
                565                 570                 575     


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr Ser Gln 
            580                 585                 590         


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
        595                 600                 605             


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
    610                 615                 620                 


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
625                 630                 635                 640 


Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
                645                 650                 655     


Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys Glu Ala 
            660                 665                 670         


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala 
        675                 680                 685             


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
    690                 695                 700                 


Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser Leu Ala 
705                 710                 715                 720 


Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
                725                 730                 735     


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
            740                 745                 750         


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
        755                 760                 765             


Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
    770                 775                 780                 


Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
785                 790                 795                 800 


Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys Phe Val 
                805                 810                 815     


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr Lys Ser 
            820                 825                 830         


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
        835                 840                 845             


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
    850                 855                 860                 


Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Gly Leu Ala Leu 
865                 870                 875                 880 


Gly Glu Glu Trp Thr Ala Ala Gly 
                885             


<210>  364
<211>  949
<212>  PRT
<213>  Homo sapiens

<400>  364

Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Thr 
1               5                   10                  15      


Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile 
            100                 105                 110         


Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
        115                 120                 125             


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
    130                 135                 140                 


Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly Asp Thr 
145                 150                 155                 160 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
                165                 170                 175     


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly Glu Thr 
            180                 185                 190         


Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr Asn Gly 
        195                 200                 205             


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu Val Arg 
    210                 215                 220                 


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn Ser Glu 
225                 230                 235                 240 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Thr 
                245                 250                 255     


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
            260                 265                 270         


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
        275                 280                 285             


Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala 
    290                 295                 300                 


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu Ala Leu 
305                 310                 315                 320 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
                325                 330                 335     


Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Thr 
            340                 345                 350         


Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Phe Thr Ser 
        355                 360                 365             


Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln Phe Gly 
    370                 375                 380                 


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
385                 390                 395                 400 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
                405                 410                 415     


Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu Ile Ala 
            420                 425                 430         


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
        435                 440                 445             


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
    450                 455                 460                 


Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
465                 470                 475                 480 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Gln Ser Lys 
                485                 490                 495     


Gly Gln Thr Leu Thr Leu Thr Gln Gln Gln Arg Asp Val Tyr Gln Gln 
            500                 505                 510         


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
        515                 520                 525             


Ser Gly Pro Glu Leu Gly Gln Leu Thr Phe Leu Gly Leu Val Gly Ile 
    530                 535                 540                 


Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr Leu Ile 
545                 550                 555                 560 


Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln Glu Thr 
                565                 570                 575     


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr Ser Gln 
            580                 585                 590         


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
        595                 600                 605             


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
    610                 615                 620                 


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
625                 630                 635                 640 


Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
                645                 650                 655     


Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys Glu Ala 
            660                 665                 670         


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala 
        675                 680                 685             


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
    690                 695                 700                 


Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser Leu Ala 
705                 710                 715                 720 


Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
                725                 730                 735     


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
            740                 745                 750         


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
        755                 760                 765             


Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
    770                 775                 780                 


Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
785                 790                 795                 800 


Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys Phe Val 
                805                 810                 815     


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr Lys Ser 
            820                 825                 830         


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
        835                 840                 845             


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
    850                 855                 860                 


Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Asp Leu Leu Phe 
865                 870                 875                 880 


Leu Leu Gly Leu Thr Ser Ser Val Cys Ile Val Ala Glu Ile Ile Lys 
                885                 890                 895     


Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Ser Ser Thr 
            900                 905                 910         


Ser Ser Ser Phe Leu Glu Val Trp Leu Trp Glu Arg Ser Gly Gln Gln 
        915                 920                 925             


Leu Val Glu Ile His Pro His Leu Glu Thr Gly Leu Pro Leu Thr Glu 
    930                 935                 940                 


Asp Val Ser Cys Val 
945                 


<210>  365
<211>  939
<212>  PRT
<213>  Homo sapiens

<400>  365

Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Thr 
1               5                   10                  15      


Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile 
            100                 105                 110         


Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
        115                 120                 125             


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
    130                 135                 140                 


Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly Asp Thr 
145                 150                 155                 160 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
                165                 170                 175     


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly Glu Thr 
            180                 185                 190         


Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr Asn Gly 
        195                 200                 205             


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu Val Arg 
    210                 215                 220                 


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn Ser Glu 
225                 230                 235                 240 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Thr 
                245                 250                 255     


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
            260                 265                 270         


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
        275                 280                 285             


Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala 
    290                 295                 300                 


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu Ala Leu 
305                 310                 315                 320 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
                325                 330                 335     


Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Thr 
            340                 345                 350         


Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Phe Thr Ser 
        355                 360                 365             


Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln Phe Gly 
    370                 375                 380                 


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
385                 390                 395                 400 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
                405                 410                 415     


Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu Ile Ala 
            420                 425                 430         


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
        435                 440                 445             


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
    450                 455                 460                 


Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
465                 470                 475                 480 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Gln Ser Lys 
                485                 490                 495     


Gly Gln Thr Leu Thr Leu Thr Gln Gln Gln Arg Asp Val Tyr Gln Gln 
            500                 505                 510         


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
        515                 520                 525             


Ser Gly Pro Glu Leu Gly Gln Leu Thr Phe Leu Gly Leu Val Gly Ile 
    530                 535                 540                 


Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr Leu Ile 
545                 550                 555                 560 


Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln Glu Thr 
                565                 570                 575     


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr Ser Gln 
            580                 585                 590         


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
        595                 600                 605             


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
    610                 615                 620                 


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
625                 630                 635                 640 


Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
                645                 650                 655     


Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys Glu Ala 
            660                 665                 670         


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala 
        675                 680                 685             


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
    690                 695                 700                 


Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser Leu Ala 
705                 710                 715                 720 


Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
                725                 730                 735     


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
            740                 745                 750         


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
        755                 760                 765             


Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
    770                 775                 780                 


Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
785                 790                 795                 800 


Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys Phe Val 
                805                 810                 815     


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr Lys Ser 
            820                 825                 830         


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
        835                 840                 845             


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
    850                 855                 860                 


Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Asp Leu Leu Phe 
865                 870                 875                 880 


Leu Leu Gly Leu Thr Ser Ser Val Cys Ile Val Ala Glu Ile Ile Lys 
                885                 890                 895     


Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Trp Leu Trp 
            900                 905                 910         


Glu Arg Ser Gly Gln Gln Leu Val Glu Ile His Pro His Leu Glu Thr 
        915                 920                 925             


Gly Leu Pro Leu Thr Glu Asp Val Ser Cys Val 
    930                 935                 


<210>  366
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  366

Met Asp Ile Pro Pro Leu Ala Gly Lys Ile Ala Ala Leu Ser Leu Ser 
1               5                   10                  15      


Ala Leu Pro Val Ser Tyr Ala Leu Asn His Val Ser Ala Leu Ser His 
            20                  25                  30          


Pro Leu Trp Val Ala Leu Met Ser Ala Leu Ile Leu Gly Leu Leu Phe 
        35                  40                  45              


Val Ala Val Tyr Ser Leu Ser His Gly Glu Val Ser Tyr Asp Pro Leu 
    50                  55                  60                  


Tyr Ala Val Phe Ala Val Phe Ala Phe Thr Ser Val Val Asp Leu Ile 
65                  70                  75                  80  


Ile Ala Leu Gln Glu Asp Ser Tyr Val Val Gly Phe Met Glu Phe Tyr 
                85                  90                  95      


Thr Lys Glu Gly Glu Pro Tyr Leu Arg Thr Ala His Gly Val Phe Ile 
            100                 105                 110         


Cys Tyr Trp Asp Gly Thr Val His Tyr Leu Leu Tyr Leu Ala Met Ala 
        115                 120                 125             


Gly Ala Ile Cys Arg Arg Lys Arg Tyr Arg Asn Phe Gly Leu Tyr Trp 
    130                 135                 140                 


Leu Gly Ser Phe Ala Met Ser Ile Leu Val Phe Leu Thr Gly Asn Ile 
145                 150                 155                 160 


Leu Gly Lys Tyr Ser Ser Glu Ile Arg Pro Ala Phe Phe Leu Thr Ile 
                165                 170                 175     


Pro Tyr Leu Leu Val Pro Cys Trp Ala Gly Met Lys Val Phe Ser Gln 
            180                 185                 190         


Pro Arg Ala Leu Thr Arg Cys Thr Ala Asn Met Val Gln Glu Glu Gln 
        195                 200                 205             


Arg Lys Gly Leu Leu Gln Arg Pro Ala Asp Leu Ala Leu Val Ile Tyr 
    210                 215                 220                 


Leu Ile Leu Ala Gly Phe Phe Thr Leu Phe Arg Gly Leu Val Val Leu 
225                 230                 235                 240 


Asp Cys Pro Thr Asp Ala Cys Phe Val Tyr Ile Tyr Gln Tyr Glu Pro 
                245                 250                 255     


Tyr Leu Arg Asp Pro Val Ala Tyr Pro Lys Val Gln Met Leu Met Tyr 
            260                 265                 270         


Met Phe Tyr Val Leu Pro Phe Cys Gly Leu Ala Ala Tyr Ala Leu Thr 
        275                 280                 285             


Phe Pro Gly Cys Ser Trp Leu Pro Asp Trp Ala Leu Val Phe Ala Gly 
    290                 295                 300                 


Gly Ile Gly Gln Ala Gln Phe Ser His Met Gly Ala Ser Met His Leu 
305                 310                 315                 320 


Arg Thr Pro Phe Thr Tyr Arg Val Pro Glu Asp Thr Trp Gly Cys Phe 
                325                 330                 335     


Phe Val Cys Asn Leu Leu Tyr Ala Leu Gly Pro His Leu Leu Ala Tyr 
            340                 345                 350         


Arg Cys Leu Gln Trp Pro Ala Phe Phe His Gln Pro Pro Pro Ser Asp 
        355                 360                 365             


Pro Leu Ala Leu His Lys Lys Gln His 
    370                 375         


<210>  367
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  367

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr Asn Asn Thr Ala 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu 
225                 230                 235                 240 


Ser His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro 
                245                 250                 255     


Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser Ser Asp Ile Cys 
            260                 265                 270         


Arg Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn Leu Lys Gly Ile 
        275                 280                 285             


Pro Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe Ala Ser Pro Val 
    290                 295                 300                 


Glu Asn Pro Asp Asn Tyr Cys Phe Cys Thr Glu Lys Ile Ile Ser Lys 
305                 310                 315                 320 


Asn Cys Thr Ser Tyr Gly Val Leu Asp Ile Ser Lys Cys Lys Glu Gly 
                325                 330                 335     


Arg Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr Ala Ser Pro Asp 
            340                 345                 350         


Val Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu Glu Glu His Arg 
        355                 360                 365             


Thr Tyr Leu Asp Ile Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ala 
    370                 375                 380                 


Lys Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser Glu Lys Ile Gln 
385                 390                 395                 400 


Val Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro Ile Leu Trp Leu 
                405                 410                 415     


Asn Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Asn Met Phe Arg Ser 
            420                 425                 430         


Gln Val Thr Gly Lys Ile Asn Leu Leu Gly Leu Ile Glu Met Ile Leu 
        435                 440                 445             


Leu Ser Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys 
    450                 455                 460                 


Ala Cys Arg Ser Lys Thr Ile Lys 
465                 470         


<210>  368
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  368

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr Asn Asn Thr Ala 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu 
225                 230                 235                 240 


Ser His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro 
                245                 250                 255     


Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser Ser Asp Ile Cys 
            260                 265                 270         


Arg Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn Leu Lys Gly Ile 
        275                 280                 285             


Pro Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe Ala Ser Pro Val 
    290                 295                 300                 


Glu Asn Pro Asp Asn Tyr Cys Phe Cys Thr Glu Lys Ile Ile Ser Lys 
305                 310                 315                 320 


Asn Cys Thr Ser Tyr Gly Val Leu Asp Ile Ser Lys Cys Lys Glu Gly 
                325                 330                 335     


Arg Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr Ala Ser Pro Asp 
            340                 345                 350         


Val Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu Glu Glu His Arg 
        355                 360                 365             


Thr Tyr Leu Asp Ile Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ala 
    370                 375                 380                 


Lys Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser Glu Lys Ile Gln 
385                 390                 395                 400 


Val Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro Ile Leu Trp Leu 
                405                 410                 415     


Asn Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Asn Met Phe Arg Ser 
            420                 425                 430         


Gln Val Thr Gly Lys Ile Asn Leu Leu Gly Leu Ile Glu Met Ile Leu 
        435                 440                 445             


Leu Ser Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys 
    450                 455                 460                 


Ala Cys Arg Ser Lys Thr Ile Lys 
465                 470         


<210>  369
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  369

Met Val Asp Val Lys Cys Leu Ser Asp Cys Lys Leu Gln Asn Gln Leu 
1               5                   10                  15      


Glu Lys Leu Gly Phe Ser Pro Gly Pro Ile Leu Pro Ser Thr Arg Lys 
            20                  25                  30          


Leu Tyr Glu Lys Lys Leu Val Gln Leu Leu Val Ser Pro Pro Cys Ala 
        35                  40                  45              


Pro Pro Val Met Asn Gly Pro Arg Glu Leu Asp Gly Ala Gln Asp Ser 
    50                  55                  60                  


Asp Asp Ser Glu Gly Gly Leu Gln Glu His Gln Ala Pro Glu Ser His 
65                  70                  75                  80  


Met Gly Leu Ser Pro Lys Arg Glu Thr Thr Ala Arg Lys Thr Arg Leu 
                85                  90                  95      


Ser Arg Ala Gly Glu Lys Lys Val Ser Gln Trp Ala 
            100                 105             


<210>  370
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  370

Met Ala Ser Ala Leu Ser Leu Gly Asn Lys Cys Asp Pro Phe Leu Arg 
1               5                   10                  15      


Cys Val Leu Cys Arg Gly Gly Gly Ala Leu Gln Gly Pro Arg Gly Arg 
            20                  25                  30          


Gly Pro Asp Asp Phe Glu Ser Gln Leu Ser Pro Pro Gly Ser Ala Arg 
        35                  40                  45              


Arg Leu Val Arg Ser Lys Arg Ala Cys Gly Asn Pro Pro Asp Ala Phe 
    50                  55                  60                  


Gly Leu Ser Arg Ala Ser Val His Pro Pro Leu Pro Arg Val Ser Ile 
65                  70                  75                  80  


Gly Cys Ser Ser Gly Pro Gly Arg Ala Lys Arg Glu Arg Val Gly Gly 
                85                  90                  95      


Ala Ala Trp Arg Gln Arg Lys Met Ala Ala Ser Ala Ala Val Phe Ser 
            100                 105                 110         


Arg Leu Arg Ser Gly Leu Arg Leu Gly Ser Arg Gly Leu Cys Thr Arg 
        115                 120                 125             


Leu Ala Thr Pro Pro Arg Arg Ala Pro Asp Gln Ala Ala Glu Ile Gly 
    130                 135                 140                 


Ser Arg Gly Ser Thr Lys Ala Gln Gly Pro Gln Gln Gln Pro Gly Ser 
145                 150                 155                 160 


Glu Gly Pro Ser Tyr Ala Lys Lys Val Ala Leu Trp Leu Ala Gly Leu 
                165                 170                 175     


Leu Gly Ala Gly Gly Thr Val Ser Val Val Tyr Ile Phe Gly Asn Asn 
            180                 185                 190         


Pro Val Asp Glu Asn Gly Ala Lys Ile Pro Asp Glu Phe Asp Asn Asp 
        195                 200                 205             


Pro Ile Leu Val Gln Gln Leu Arg Arg Thr Tyr Lys Tyr Phe Lys Asp 
    210                 215                 220                 


Tyr Arg Gln Met Ile Ile Glu Pro Thr Ser Pro Cys Leu Leu Pro Asp 
225                 230                 235                 240 


Pro Leu Gln Glu Pro Tyr Tyr Gln Pro Pro Tyr Thr Leu Val Leu Glu 
                245                 250                 255     


Leu Thr Gly Val Leu Leu His Pro Glu Trp Ser Leu Ala Thr Gly Trp 
            260                 265                 270         


Arg Phe Lys Lys Arg Pro Gly Ile Glu Thr Leu Phe Gln Gln Leu Ala 
        275                 280                 285             


Pro Leu Tyr Glu Ile Val Ile Phe Thr Ser Glu Thr Gly Met Thr Ala 
    290                 295                 300                 


Phe Pro Leu Ile Asp Ser Val Asp Pro His Gly Phe Ile Ser Tyr Arg 
305                 310                 315                 320 


Leu Phe Arg Asp Ala Thr Arg Tyr Met Asp Gly His His Val Lys Asp 
                325                 330                 335     


Ile Ser Cys Leu Asn Arg Asp Pro Ala Arg Val Val Val Val Asp Cys 
            340                 345                 350         


Lys Lys Glu Ala Phe Arg Leu Gln Pro Tyr Asn Gly Val Ala Leu Arg 
        355                 360                 365             


Pro Trp Asp Gly Asn Ser Asp Asp Arg Val Leu Leu Asp Leu Ser Ala 
    370                 375                 380                 


Phe Leu Lys Thr Ile Ala Leu Asn Gly Val Glu Asp Val Arg Thr Val 
385                 390                 395                 400 


Leu Glu His Tyr Ala Leu Glu Asp Asp Pro Leu Ala Ala Phe Lys Gln 
                405                 410                 415     


Arg Gln Ser Arg Leu Glu Gln Glu Glu Gln Gln Arg Leu Ala Glu Leu 
            420                 425                 430         


Ser Lys Ser Asn Lys Gln Asn Leu Phe Leu Gly Ser Leu Thr Ser Arg 
        435                 440                 445             


Leu Trp Pro Arg Ser Lys Gln Pro 
    450                 455     


<210>  371
<211>  681
<212>  PRT
<213>  Homo sapiens

<400>  371

Met Gly Lys Gly Val Gly Arg Asp Lys Tyr Glu Pro Ala Ala Val Ser 
1               5                   10                  15      


Glu Gln Gly Asp Lys Lys Gly Lys Lys Gly Lys Lys Asp Arg Asp Met 
            20                  25                  30          


Asp Glu Leu Lys Lys Glu Val Ser Met Asp Asp His Lys Leu Ser Leu 
        35                  40                  45              


Asp Glu Leu His Arg Lys Tyr Gly Thr Asp Leu Ser Arg Gly Leu Thr 
    50                  55                  60                  


Ser Ala Arg Ala Ala Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala Leu 
65                  70                  75                  80  


Thr Pro Pro Pro Thr Thr Pro Glu Trp Ile Lys Phe Cys Arg Gln Leu 
                85                  90                  95      


Phe Gly Gly Phe Ser Met Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe 
            100                 105                 110         


Leu Ala Tyr Ser Ile Gln Ala Ala Thr Glu Glu Glu Pro Gln Asn Asp 
        115                 120                 125             


Asn Leu Tyr Leu Gly Val Val Leu Ser Ala Val Val Ile Ile Thr Gly 
    130                 135                 140                 


Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Glu Ser 
145                 150                 155                 160 


Phe Lys Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Asn Gly Glu 
                165                 170                 175     


Lys Met Ser Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val Glu 
            180                 185                 190         


Val Lys Gly Gly Asp Arg Ile Pro Ala Asp Leu Arg Ile Ile Ser Ala 
        195                 200                 205             


Asn Gly Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro 
    210                 215                 220                 


Gln Thr Arg Ser Pro Asp Phe Thr Asn Glu Asn Pro Leu Glu Thr Arg 
225                 230                 235                 240 


Asn Ile Ala Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly 
                245                 250                 255     


Ile Val Val Tyr Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr 
            260                 265                 270         


Leu Ala Ser Gly Leu Glu Gly Gly Gln Thr Pro Ile Ala Ala Glu Ile 
        275                 280                 285             


Glu His Phe Ile His Ile Ile Thr Gly Val Ala Val Phe Leu Gly Val 
    290                 295                 300                 


Ser Phe Phe Ile Leu Ser Leu Ile Leu Glu Tyr Thr Trp Leu Glu Ala 
305                 310                 315                 320 


Val Ile Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu 
                325                 330                 335     


Leu Ala Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala 
            340                 345                 350         


Arg Lys Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly 
        355                 360                 365             


Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn 
    370                 375                 380                 


Arg Met Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala 
385                 390                 395                 400 


Asp Thr Thr Glu Asn Gln Ser Gly Val Ser Phe Asp Lys Thr Ser Ala 
                405                 410                 415     


Thr Trp Leu Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val 
            420                 425                 430         


Phe Gln Ala Asn Gln Glu Asn Leu Pro Ile Leu Lys Arg Ala Val Ala 
        435                 440                 445             


Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Cys Cys 
    450                 455                 460                 


Gly Ser Val Lys Glu Met Arg Glu Arg Tyr Ala Lys Ile Val Glu Ile 
465                 470                 475                 480 


Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Lys Asn Pro 
                485                 490                 495     


Asn Thr Ser Glu Pro Gln His Leu Leu Val Met Lys Gly Ala Pro Glu 
            500                 505                 510         


Arg Ile Leu Asp Arg Cys Ser Ser Ile Leu Leu His Gly Lys Glu Gln 
        515                 520                 525             


Pro Leu Asp Glu Glu Leu Lys Asp Ala Phe Gln Asn Ala Tyr Leu Glu 
    530                 535                 540                 


Leu Gly Gly Leu Gly Glu Arg Val Leu Gly Phe Cys His Leu Phe Leu 
545                 550                 555                 560 


Pro Asp Glu Gln Phe Pro Glu Gly Phe Gln Phe Asp Thr Asp Asp Val 
                565                 570                 575     


Asn Phe Pro Ile Asp Asn Leu Cys Phe Val Gly Leu Ile Ser Met Ile 
            580                 585                 590         


Asp Pro Pro Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser 
        595                 600                 605             


Ala Gly Ile Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala 
    610                 615                 620                 


Lys Ala Ile Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Gly Pro 
625                 630                 635                 640 


Met Ser Arg Gly Lys Ser Trp Ser Ser Pro Ala Thr Gln Pro Ser Ser 
                645                 650                 655     


Ser Val Ser Trp Trp Cys Ser Gly Pro Thr Trp Ser Ser Val Arg Pro 
            660                 665                 670         


Gly Gly Ile Arg Ser Ser Ser Arg Gly 
        675                 680     


<210>  372
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  372

Met Arg Met Ala Ala Thr Ala Trp Ala Gly Leu Gln Gly Pro Pro Leu 
1               5                   10                  15      


Pro Thr Leu Cys Pro Ala Val Arg Thr Gly Leu Tyr Cys Arg Asp Gln 
            20                  25                  30          


Ala His Ala Glu Arg Trp Ala Met Thr Ser Glu Thr Ser Ser Gly Ser 
        35                  40                  45              


His Cys Ala Arg Ser Arg Met Leu Arg Arg Arg Ala Gln Glu Glu Asp 
    50                  55                  60                  


Ser Thr Val Leu Ile Asp Val Ser Pro Pro Glu Ala Glu Lys Arg Gly 
65                  70                  75                  80  


Ser Tyr Gly Ser Thr Ala His Ala Ser Glu Pro Gly Gly Gln Gln Ala 
                85                  90                  95      


Ala Ala Cys Arg Ala Gly Ser Pro Ala Lys Pro Arg Ile Asp Phe Val 
            100                 105                 110         


Leu Val Trp Glu Glu Asp Leu Lys Leu Asp Arg Gln Gln Asp Ser Ala 
        115                 120                 125             


Ala Arg Asp Arg Thr Asp Met His Arg Thr Trp Arg Glu Thr Phe Leu 
    130                 135                 140                 


Asp Asn Leu Arg Ala Ala Gly Leu Cys Val Asp Gln Val Arg Gly Gly 
145                 150                 155                 160 


Cys His Gly Gln Gly Pro Arg Pro Cys Ile His Ser Val Thr His Asp 
                165                 170                 175     


Leu Ala Ala 
            


<210>  373
<211>  1576
<212>  PRT
<213>  Homo sapiens

<400>  373

Met Glu Asn Ile Leu Cys Phe Leu Asn Ser Tyr Thr Glu Thr Gly Leu 
1               5                   10                  15      


Ser Pro Asp Ser His Trp Leu Asp Ile Asp Pro Asn Phe Ile Cys Leu 
            20                  25                  30          


Ser Gly Leu Gly Leu Phe Ile Leu Tyr Leu Phe Tyr Val Val Leu Thr 
        35                  40                  45              


Leu Tyr Ser Ser Pro Thr Glu Lys Asn Asn Asp Ile Gln Lys His Gln 
    50                  55                  60                  


Gly Arg Ala Lys Arg Arg Arg Lys Gly Gly Thr Phe Lys Gly Phe Pro 
65                  70                  75                  80  


Asp Trp Lys Ser Phe Gln Arg Glu Glu Glu Glu Glu Arg Lys Leu Leu 
                85                  90                  95      


Ser Leu Leu Lys Ser Phe Gly Pro Pro Val Ser Cys Ser Pro Arg Gly 
            100                 105                 110         


Gln His His Asp Thr Asn His Phe Arg Arg Leu Leu Cys Pro Asp Pro 
        115                 120                 125             


Val Cys Arg Val Cys Lys Arg Ala Thr Ala Asp Ile Gln Gln Leu Leu 
    130                 135                 140                 


Ser Trp Glu Ser Leu Lys Asp Ala Ala Pro Ser Val Ser Pro Leu Ala 
145                 150                 155                 160 


Ser Ser Ala Ser Ala Thr Glu Ser Ser Phe Thr Leu Ala Ser Thr Pro 
                165                 170                 175     


Ser Ala Thr Pro Pro Glu Asp Leu Ile Leu Ser Pro Arg Pro Lys Ala 
            180                 185                 190         


Ser Pro Pro Pro Pro Leu Ile Leu Ser Pro Asp Leu Ile Thr Thr Leu 
        195                 200                 205             


Ala Asp Leu Phe Ser Pro Ser Pro Leu Arg Asp Pro Leu Pro Pro Gln 
    210                 215                 220                 


Pro Val Ser Pro Leu Asp Ser Lys Phe Pro Ile Asp His Ser Pro Pro 
225                 230                 235                 240 


Gln Gln Leu Pro Phe Pro Leu Leu Pro Pro His His Ile Glu Arg Val 
                245                 250                 255     


Glu Ser Ser Leu Gln Pro Glu Ala Ser Leu Ser Leu Asn Thr Ile Phe 
            260                 265                 270         


Ser Phe Gly Ser Thr Leu Cys Gln Asp Ile Ser Gln Ala Met Asn Pro 
        275                 280                 285             


Ile Asp Ser Cys Ala Arg His His Gly Pro Pro Ile Pro Ser Ala Leu 
    290                 295                 300                 


Pro Pro Glu Asp Cys Thr Val Thr Gln Ser Lys Ser Ser Leu Thr Ile 
305                 310                 315                 320 


Leu Lys Thr Phe Pro Glu Met Leu Ser Leu Gly Gly Ser Gly Gly Ser 
                325                 330                 335     


Ser Thr Ser Ala Pro Thr Ile Lys Gly Ile Asp His Ser His Leu Ala 
            340                 345                 350         


Ser Ser Glu Phe Thr Trp Trp Gln Pro His Ala Lys Asp Ser Phe Ser 
        355                 360                 365             


Ser Asn Phe Val Pro Ser Asp Phe Met Glu Glu Leu Leu Thr Leu His 
    370                 375                 380                 


Ser Ser Glu Ala Phe Leu Gly Gly His Ser Val Ala Asn Leu Ile Glu 
385                 390                 395                 400 


Pro Val Asn Ile Ser Phe Leu Ser His Asp Ile Leu Ala Leu Leu Glu 
                405                 410                 415     


Arg Gln Val Lys Lys Arg Gly Asp Phe Leu Met Trp Lys Glu Asn Gly 
            420                 425                 430         


Lys Lys Pro Gly Ser Phe Pro Lys Gln Leu Arg Pro Asn Tyr Gln Leu 
        435                 440                 445             


Asn Ser Ser Arg Asn Met Leu Thr Ser Ile Ala Val Lys His Asp Leu 
    450                 455                 460                 


Ala Glu Ser Phe Pro Phe Trp Ala Ser Lys Gly Lys Leu Glu Trp Gln 
465                 470                 475                 480 


His Ile His Gln Gln Pro Pro His Ser Lys Cys Phe Glu Asp His Leu 
                485                 490                 495     


Glu Gln Lys Tyr Val Gln Leu Phe Trp Gly Leu Pro Ser Leu His Ser 
            500                 505                 510         


Glu Ser Leu His Pro Thr Val Leu Val Gln Arg Gly His Ser Ser Met 
        515                 520                 525             


Phe Val Phe Phe Asn Gly Ile Thr Asn Thr Ser Ile Ser His Glu Ser 
    530                 535                 540                 


Pro Val Leu Pro Pro Pro Gln Pro Leu Ser Leu Pro Ser Thr Gln Pro 
545                 550                 555                 560 


Leu Pro Leu Pro Gln Thr Leu Pro Gln Gly Gln Ser Pro His Leu Thr 
                565                 570                 575     


Gln Val Lys Ser Leu Ala Gln Pro Gln Ser Pro Phe Arg Ala Leu Leu 
            580                 585                 590         


Pro Ser Pro Leu Phe Leu Ile Arg Ile Cys Gly Val Cys Phe His Arg 
        595                 600                 605             


Pro Gln Asn Glu Ala Arg Ser Leu Leu Pro Ser Glu Ile Asn His Leu 
    610                 615                 620                 


Glu Trp Asn Val Leu Gln Lys Val Gln Glu Ser Leu Trp Gly Leu Pro 
625                 630                 635                 640 


Ser Val Val Gln Lys Ser Gln Glu Asp Phe Cys Pro Pro Ala Pro Asn 
                645                 650                 655     


Pro Glu Leu Val Arg Lys Ser Phe Lys Val His Val Pro Ile Ser Ile 
            660                 665                 670         


Ile Pro Gly Asp Phe Pro Leu Ser Ser Glu Val Arg Lys Lys Leu Glu 
        675                 680                 685             


Gln His Ile Arg Arg Arg Leu Ile Gln Arg Arg Trp Gly Leu Pro Arg 
    690                 695                 700                 


Arg Ile His Glu Ser Leu Ser Leu Leu Arg Pro Gln Ser Lys Ile Ser 
705                 710                 715                 720 


Glu Leu Ser Val Ser Glu Arg Ile His Gly Pro Leu Asn Ile Ser Leu 
                725                 730                 735     


Val Glu Gly Gln Arg Cys Asn Val Leu Lys Lys Ser Ala Ser Ser Phe 
            740                 745                 750         


Pro Arg Ser Phe His Glu Arg Ser Ser Asn Met Leu Ser Met Glu Asn 
        755                 760                 765             


Val Gly Asn Tyr Gln Gly Tyr Ser Gln Glu Thr Val Pro Lys Asp His 
    770                 775                 780                 


Leu Leu His Gly Pro Glu Thr Ser Ser Asp Lys Asp Leu Arg Ser Asn 
785                 790                 795                 800 


Ser Glu Arg Asp Leu Glu Thr His Met Met His Leu Ser Gly Asn Asp 
                805                 810                 815     


Ser Gly Val Arg Leu Gly Gln Lys Gln Leu Glu Asn Ala Leu Thr Val 
            820                 825                 830         


Arg Leu Ser Lys Lys Phe Glu Glu Ile Asn Glu Gly Arg Met Pro Gly 
        835                 840                 845             


Thr Val His Ser Ser Trp His Ser Val Lys Gln Thr Met Ser Leu Pro 
    850                 855                 860                 


Glu Lys Ser His Ser Gln Ile Lys His Arg Asn Leu Val Thr Leu Val 
865                 870                 875                 880 


Ser Glu Asp His Cys Val Asp Thr Ser Gln Glu Ile Ser Phe Leu Ser 
                885                 890                 895     


Ser Asn Lys Gln Lys Met Leu Glu Ala His Ile Lys Thr Phe Arg Met 
            900                 905                 910         


Arg Met Leu Trp Gly Leu Pro Leu Lys Val Leu Glu Ser Ile Glu Ile 
        915                 920                 925             


Phe Lys Ser Lys Ala Asp Leu Ser Thr Ser Phe Ser His Phe Asp Leu 
    930                 935                 940                 


Pro Ser Ser Ala Thr Phe Ile Ser Gln Gly Asp Ser Lys Asp Gly Val 
945                 950                 955                 960 


Ser Lys Ser Arg Ser Arg Ser Thr Phe Gln Gly Glu Lys Leu Gly Thr 
                965                 970                 975     


Thr Ser Ser Val Pro Ile Leu Asp Arg Pro His Pro Val Ser Ser Pro 
            980                 985                 990         


Val Val Gln Glu Gly Gln Gly Thr  Leu Arg Arg Gln Phe  Ser Asp Thr 
        995                 1000                 1005             


Asp His  Asp Leu Ile Glu Thr  Asp Ser Lys Asp Gly  Ala Ser Thr 
    1010                 1015                 1020             


Ser Leu  Arg Arg Gly Thr Thr  Asp Phe Gln Ser Glu  Lys Leu Asp 
    1025                 1030                 1035             


Ser Thr  Ser Ser Phe Pro Ile  Leu Gly His Ser Tyr  Leu Val Thr 
    1040                 1045                 1050             


Ser Pro  Val Asn Gln Glu Lys  Gln Gly Thr Leu Arg  Arg Glu Phe 
    1055                 1060                 1065             


Ser Asp  Thr Asp Asn Asp Leu  Thr Glu Ser Val Arg  Thr Thr Glu 
    1070                 1075                 1080             


Asp Gly  Arg Gln Thr Phe Leu  Pro Pro Pro His Ser  Ile Val Asp 
    1085                 1090                 1095             


Glu Val  Ser Gln Lys Gln Thr  Val Leu Ala Ser Arg  Cys Ser Ala 
    1100                 1105                 1110             


Glu Leu  Pro Ile Met Gln Ala  Gly Ala Gly Cys Glu  Ser Trp Asp 
    1115                 1120                 1125             


Lys Arg  Lys Ser Ser Phe His  Asn Val Asp Arg Leu  Gln Gly Ser 
    1130                 1135                 1140             


Arg Lys  Thr Phe Pro Val Thr  Asn Ala Leu Gln Ser  Gln Thr Arg 
    1145                 1150                 1155             


Asn Asn  Leu Thr Thr Ser Lys  Ser Gly Ser Cys Ser  Leu Thr Asn 
    1160                 1165                 1170             


Val Lys  Ala Ser Thr Ser Asn  Glu Thr Glu Ile Phe  Pro Pro Arg 
    1175                 1180                 1185             


Ile Ser  Val Pro Gln Asp Pro  Lys Ser Ser Tyr Leu  Lys Asn Gln 
    1190                 1195                 1200             


Met Leu  Ser Gln Leu Lys Leu  Val Gln Arg Lys His  Ser Gln Pro 
    1205                 1210                 1215             


Gln Ser  His Phe Thr Asp Met  Ser Phe Ala Leu Asp  Asn Leu Ser 
    1220                 1225                 1230             


Ser Lys  Asp Leu Leu Thr Asn  Ser Gln Gly Ile Ser  Ser Gly Asp 
    1235                 1240                 1245             


Met Gly  Thr Ser Gln Val Val  His Val His Leu Glu  Asp Ser Gly 
    1250                 1255                 1260             


Ile Arg  Val Ala Gln Lys Gln  Glu Pro Arg Val Pro  Thr Cys Val 
    1265                 1270                 1275             


Leu Gln  Lys Cys Gln Val Thr  Asn Phe Pro Pro Ala  Val Asn Arg 
    1280                 1285                 1290             


Val Ser  Pro Val Arg Pro Lys  Gly Gly Glu Leu Asp  Gly Gly Asp 
    1295                 1300                 1305             


Ala Gly  Leu Gly Thr Ser Gln  Arg Arg Arg Lys Ser  Leu Pro Val 
    1310                 1315                 1320             


His Asn  Lys Thr Ser Gly Glu  Val Leu Gly Ser Lys  Ser Ser Pro 
    1325                 1330                 1335             


Thr Leu  Lys Thr Gln Pro Pro  Pro Glu Asn Leu Phe  Arg Lys Trp 
    1340                 1345                 1350             


Met Lys  Thr Ser Leu Gln Trp  Phe Asn Lys Pro Ser  Ile Ser Tyr 
    1355                 1360                 1365             


Glu Glu  Gln Glu Ser Ser Trp  Glu Lys Gly Ser Ser  Leu Ser Ser 
    1370                 1375                 1380             


Cys Val  Gln Asn Ile Gly Arg  Val Ile Arg Ala Ala  Phe Thr Gly 
    1385                 1390                 1395             


Thr Thr  Glu Ala Gln Lys Ile  Arg Lys Asp Thr Arg  Glu Phe Leu 
    1400                 1405                 1410             


Glu Glu  Lys Leu Gly His Arg  His Gly Ile Asp Ile  Thr Cys Pro 
    1415                 1420                 1425             


Gln Glu  Pro Leu Ser Phe Pro  Val Gly Leu Gly Lys  Ala Gln His 
    1430                 1435                 1440             


Asn Pro  Glu Val His Val Arg  Ala Glu Pro Val Gln  Gly Cys Pro 
    1445                 1450                 1455             


Cys Asn  Tyr Arg Ala Pro Ser  Cys Lys Val Thr Arg  Thr Lys Ser 
    1460                 1465                 1470             


Cys Ser  Gln Gln Ala Ile Phe  Val Gly Gln Asn Tyr  Pro Thr Arg 
    1475                 1480                 1485             


Ile Arg  Gln Ile Ile Asp Lys  Asp Arg Gln Pro Gln  Lys Val Glu 
    1490                 1495                 1500             


Ala Phe  Lys Gly Lys Ile Leu  Cys Gln Ser His Pro  Gln Ser Met 
    1505                 1510                 1515             


Pro His  Arg Lys Pro Val Pro  His Pro Asn Pro Thr  Cys Arg Arg 
    1520                 1525                 1530             


Gln Val  Ser Leu Val Cys Pro  Ala Val Pro Thr Ser  Ala Lys Ser 
    1535                 1540                 1545             


Pro Val  Phe Ser Asp Val Pro  Phe Leu Thr Gly Gln  Lys Met Leu 
    1550                 1555                 1560             


Pro Lys  His Leu Gln Gly Gly  Lys Phe Pro Pro Thr  Lys 
    1565                 1570                 1575     


<210>  374
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  374

Met Glu Val Asp Ala Pro Gly Val Asp Gly Arg Asp Gly Leu Arg Glu 
1               5                   10                  15      


Arg Arg Gly Phe Ser Glu Gly Gly Arg Gln Asn Phe Asp Val Arg Pro 
            20                  25                  30          


Gln Ser Gly Ala Asn Gly Leu Pro Lys His Ser Tyr Trp Leu Asp Leu 
        35                  40                  45              


Trp Leu Phe Ile Leu Phe Asp Val Val Val Phe Leu Phe Val Tyr Phe 
    50                  55                  60                  


Leu Pro 
65      


<210>  375
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  375

Met Arg Gln Gly Leu Leu Val Leu Ala Leu Val Leu Val Leu Val Leu 
1               5                   10                  15      


Val Leu Ala Ala Gly Ser Gln Val Gln Glu Trp Tyr Pro Arg Glu Ser 
            20                  25                  30          


His Ala Leu Asn Trp Asn Lys Phe Ser Gly Phe Trp Tyr Ile Leu Ala 
        35                  40                  45              


Thr Ala Thr Asp Ala Gln Gly Phe Leu Pro Ala Arg Asp Lys Arg Lys 
    50                  55                  60                  


Leu Gly Ala Ser Val Val Lys Val Asn Lys Val Gly Gln Leu Arg Val 
65                  70                  75                  80  


Leu Leu Ala Phe Arg Arg Leu Lys Gly Cys Gln Ser Gln Glu Val Ile 
                85                  90                  95      


Leu Arg Lys Asp Gly Lys Lys Pro Val Phe Gly Asn Ala Cys Ala Tyr 
            100                 105                 110         


Ala Ala Gly Pro Arg Glu Gly Gln Glu Gly Val Lys Gly Val Lys Ala 
        115                 120                 125             


Phe His Val Leu Ser Thr Asp Tyr Ser Tyr Gly Leu Val Tyr Leu Arg 
    130                 135                 140                 


Leu Gly Arg Ala Thr Gln Asn Tyr Lys Asn Leu Leu Leu Phe His Arg 
145                 150                 155                 160 


Gln Asn Val Ser Ser Phe Gln Ser Leu Lys Glu Phe Met Asp Ala Cys 
                165                 170                 175     


Asp Ile Leu Gly Leu Ser Lys Ala Ala Val Ile Leu Pro Lys Asp Ala 
            180                 185                 190         


Ser Arg Thr His Thr Ile Leu Pro 
        195                 200 


<210>  376
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  376

Met Ile Gln Ala Leu Ala Gly Phe Phe Thr Tyr Phe Val Ile Leu Ala 
1               5                   10                  15      


Glu Asn Gly Phe Arg Pro Val Asp Leu Leu Gly Ile Arg Leu His Trp 
            20                  25                  30          


Glu Asp Lys Tyr Leu Asn Asp Leu Glu Asp Ser Tyr Gly Gln Gln Trp 
        35                  40                  45              


Thr Tyr Glu Gln Arg Lys Val Val Glu Phe Thr Cys Gln Thr Ala Phe 
    50                  55                  60                  


Phe Val Thr Ile Val Val Val Gln Trp Ala Asp Leu Ile Ile Ser Lys 
65                  70                  75                  80  


Thr Arg Arg Asn Ser Leu Phe Gln Gln Gly Met Arg Asn Lys Val Leu 
                85                  90                  95      


Ile Phe Gly Ile Leu Glu Glu Thr Leu Leu Ala Ala Phe Leu Ser Tyr 
            100                 105                 110         


Thr Pro Gly Met Asp Val Ala Leu Arg Met Tyr Pro Leu Lys Ile Thr 
        115                 120                 125             


Trp Trp Leu Cys Ala Ile Pro Tyr Ser Ile Leu Ile Phe Val Tyr Asp 
    130                 135                 140                 


Glu Ile Arg Lys Leu Leu Ile Arg Gln His Pro Asp Gly Trp Val Glu 
145                 150                 155                 160 


Arg Glu Thr Tyr Tyr 
                165 


<210>  377
<211>  774
<212>  PRT
<213>  Homo sapiens

<400>  377

Met Arg Gly Pro Ile Val Leu His Ile Cys Leu Ala Phe Cys Ser Leu 
1               5                   10                  15      


Leu Leu Phe Ser Val Ala Thr Gln Cys Leu Ala Phe Pro Lys Ile Glu 
            20                  25                  30          


Arg Arg Arg Glu Ile Ala His Val His Ala Glu Lys Gly Gln Ser Asp 
        35                  40                  45              


Lys Met Asn Thr Asp Asp Leu Glu Asn Ser Ser Val Thr Ser Lys Gln 
    50                  55                  60                  


Thr Pro Gln Leu Val Val Ser Glu Asp Pro Met Met Met Ser Ala Val 
65                  70                  75                  80  


Pro Ser Ala Thr Ser Leu Asn Lys Ala Phe Ser Ile Asn Lys Glu Thr 
                85                  90                  95      


Gln Pro Gly Gln Ala Gly Leu Met Gln Thr Glu Arg Pro Gly Val Ser 
            100                 105                 110         


Thr Pro Thr Glu Ser Gly Val Pro Ser Ala Glu Glu Val Phe Gly Ser 
        115                 120                 125             


Ser Gln Pro Glu Arg Ile Ser Pro Glu Ser Gly Leu Ala Lys Ala Met 
    130                 135                 140                 


Leu Thr Ile Ala Ile Thr Ala Thr Pro Ser Leu Thr Val Asp Glu Lys 
145                 150                 155                 160 


Glu Glu Leu Leu Thr Ser Thr Asn Phe Gln Pro Ile Val Glu Glu Ile 
                165                 170                 175     


Thr Glu Thr Thr Lys Gly Phe Leu Lys Tyr Met Asp Asn Gln Ser Phe 
            180                 185                 190         


Ala Thr Glu Ser Gln Glu Gly Val Gly Leu Gly His Ser Pro Ser Ser 
        195                 200                 205             


Tyr Val Asn Thr Lys Glu Met Leu Thr Thr Asn Pro Lys Thr Glu Lys 
    210                 215                 220                 


Phe Glu Ala Asp Thr Asp His Arg Thr Thr Ser Phe Pro Gly Ala Glu 
225                 230                 235                 240 


Ser Thr Ala Gly Ser Glu Pro Gly Ser Leu Thr Pro Asp Lys Glu Lys 
                245                 250                 255     


Pro Ser Gln Met Thr Ala Asp Asn Thr Gln Ala Ala Ala Thr Lys Gln 
            260                 265                 270         


Pro Leu Glu Thr Ser Glu Tyr Thr Leu Ser Val Glu Pro Glu Thr Asp 
        275                 280                 285             


Ser Leu Leu Gly Ala Pro Glu Val Thr Val Ser Val Ser Thr Ala Val 
    290                 295                 300                 


Pro Ala Ala Ser Ala Leu Ser Asp Glu Trp Asp Asp Thr Lys Leu Glu 
305                 310                 315                 320 


Ser Val Ser Arg Ile Arg Thr Pro Lys Leu Gly Asp Asn Glu Glu Thr 
                325                 330                 335     


Gln Val Arg Thr Glu Met Ser Gln Thr Ala Gln Val Ser His Glu Gly 
            340                 345                 350         


Met Glu Gly Gly Gln Pro Trp Thr Glu Ala Ala Gln Val Ala Leu Gly 
        355                 360                 365             


Leu Pro Glu Gly Glu Thr His Thr Gly Thr Ala Leu Leu Ile Ala His 
    370                 375                 380                 


Gly Asn Glu Arg Ser Pro Ala Phe Thr Asp Gln Ser Ser Phe Thr Pro 
385                 390                 395                 400 


Thr Ser Leu Met Glu Asp Met Lys Val Ser Ile Val Asn Leu Leu Gln 
                405                 410                 415     


Ser Thr Gly Asp Phe Thr Glu Ser Thr Lys Glu Asn Asp Ala Leu Phe 
            420                 425                 430         


Phe Leu Glu Thr Thr Val Ser Val Ser Val Tyr Glu Ser Glu Ala Asp 
        435                 440                 445             


Gln Leu Leu Gly Asn Thr Met Lys Asp Ile Ile Thr Gln Glu Met Thr 
    450                 455                 460                 


Thr Ala Val Gln Glu Pro Asp Ala Thr Leu Ser Met Val Thr Gln Glu 
465                 470                 475                 480 


Gln Val Ala Thr Leu Glu Leu Ile Arg Asp Ser Gly Lys Thr Glu Glu 
                485                 490                 495     


Glu Lys Glu Asp Pro Ser Pro Val Ser Asp Val Pro Gly Val Thr Gln 
            500                 505                 510         


Leu Ser Arg Arg Trp Glu Pro Leu Ala Thr Thr Ile Ser Thr Thr Val 
        515                 520                 525             


Val Pro Leu Ser Phe Glu Val Thr Pro Thr Val Glu Glu Gln Met Asp 
    530                 535                 540                 


Thr Val Thr Gly Pro Asn Glu Glu Phe Thr Pro Val Leu Gly Ser Pro 
545                 550                 555                 560 


Val Thr Pro Pro Gly Ile Met Val Gly Glu Pro Ser Ile Ser Pro Ala 
                565                 570                 575     


Leu Pro Ala Leu Glu Ala Ser Ser Glu Arg Arg Thr Val Val Pro Ser 
            580                 585                 590         


Ile Thr Arg Val Asn Thr Ala Ala Ser Tyr Gly Leu Asp Gln Leu Glu 
        595                 600                 605             


Ser Glu Glu Gly Gln Glu Asp Glu Asp Glu Glu Asp Glu Glu Asp Glu 
    610                 615                 620                 


Asp Glu Glu Glu Glu Asp Glu Glu Glu Asp Glu Glu Asp Lys Asp Ala 
625                 630                 635                 640 


Asp Ser Leu Asp Glu Gly Leu Asp Gly Asp Thr Glu Leu Pro Gly Phe 
                645                 650                 655     


Thr Leu Pro Gly Ile Thr Ser Gln Glu Pro Gly Leu Glu Glu Gly Asn 
            660                 665                 670         


Met Asp Leu Leu Glu Gly Ala Thr Tyr Gln Val Pro Asp Ala Leu Glu 
        675                 680                 685             


Trp Glu Gln Gln Asn Gln Gly Leu Val Arg Ser Trp Met Glu Lys Leu 
    690                 695                 700                 


Lys Asp Lys Ala Gly Tyr Met Ser Gly Met Leu Val Pro Val Gly Val 
705                 710                 715                 720 


Gly Ile Ala Gly Ala Leu Phe Ile Leu Gly Ala Leu Tyr Ser Ile Lys 
                725                 730                 735     


Val Met Asn Arg Arg Arg Arg Asn Gly Phe Lys Arg His Lys Arg Lys 
            740                 745                 750         


Gln Arg Glu Phe Asn Ser Met Gln Asp Arg Val Met Leu Leu Ala Asp 
        755                 760                 765             


Ser Ser Glu Asp Glu Phe 
    770                 


<210>  378
<211>  933
<212>  PRT
<213>  Homo sapiens

<400>  378

Met Arg Met Ala Ala Thr Ala Trp Ala Gly Leu Gln Gly Pro Pro Leu 
1               5                   10                  15      


Pro Thr Leu Cys Pro Ala Val Arg Thr Gly Leu Tyr Cys Arg Asp Gln 
            20                  25                  30          


Ala His Ala Glu Arg Trp Ala Met Thr Ser Glu Thr Ser Ser Gly Ser 
        35                  40                  45              


His Cys Ala Arg Ser Arg Met Leu Arg Arg Arg Ala Gln Glu Glu Asp 
    50                  55                  60                  


Ser Thr Val Leu Ile Asp Val Ser Pro Pro Glu Ala Glu Lys Arg Gly 
65                  70                  75                  80  


Ser Tyr Gly Ser Thr Ala His Ala Ser Glu Pro Gly Gly Gln Gln Ala 
                85                  90                  95      


Ala Ala Cys Arg Ala Gly Ser Pro Ala Lys Pro Arg Ile Ala Asp Phe 
            100                 105                 110         


Val Leu Val Trp Glu Glu Asp Leu Lys Leu Asp Arg Gln Gln Asp Ser 
        115                 120                 125             


Ala Ala Arg Asp Arg Thr Asp Met His Arg Thr Trp Arg Glu Thr Phe 
    130                 135                 140                 


Leu Asp Asn Leu Arg Ala Ala Gly Leu Cys Val Asp Gln Gln Asp Val 
145                 150                 155                 160 


Gln Asp Gly Asn Thr Thr Val His Tyr Ala Leu Leu Ser Ala Ser Trp 
                165                 170                 175     


Ala Val Leu Cys Tyr Tyr Ala Glu Asp Leu Arg Leu Lys Leu Pro Leu 
            180                 185                 190         


Gln Glu Leu Pro Asn Gln Ala Ser Asn Trp Ser Ala Gly Leu Leu Ala 
        195                 200                 205             


Trp Leu Gly Ile Pro Asn Val Leu Leu Glu Val Val Pro Asp Val Pro 
    210                 215                 220                 


Pro Glu Tyr Tyr Ser Cys Arg Phe Arg Val Asn Lys Leu Pro Arg Phe 
225                 230                 235                 240 


Leu Gly Ser Asp Asn Gln Asp Thr Phe Phe Thr Ser Thr Lys Arg His 
                245                 250                 255     


Gln Ile Leu Phe Glu Ile Leu Ala Lys Thr Pro Tyr Gly His Glu Lys 
            260                 265                 270         


Lys Asn Leu Leu Gly Ile His Gln Leu Leu Ala Glu Gly Val Leu Ser 
        275                 280                 285             


Ala Ala Phe Pro Leu His Asp Gly Pro Phe Lys Thr Pro Pro Glu Gly 
    290                 295                 300                 


Pro Gln Ala Pro Arg Leu Asn Gln Arg Gln Val Leu Phe Gln His Trp 
305                 310                 315                 320 


Ala Arg Trp Gly Lys Trp Asn Lys Tyr Gln Pro Leu Asp His Val Arg 
                325                 330                 335     


Arg Tyr Phe Gly Glu Lys Val Ala Leu Tyr Phe Ala Trp Leu Gly Phe 
            340                 345                 350         


Tyr Thr Gly Trp Leu Leu Pro Ala Ala Val Val Gly Thr Leu Val Phe 
        355                 360                 365             


Leu Val Gly Cys Phe Leu Val Phe Ser Asp Ile Pro Thr Gln Glu Leu 
    370                 375                 380                 


Cys Gly Ser Lys Asp Ser Phe Glu Met Cys Pro Leu Cys Leu Asp Cys 
385                 390                 395                 400 


Pro Phe Trp Leu Leu Ser Ser Ala Cys Ala Leu Ala Gln Ala Gly Arg 
                405                 410                 415     


Leu Phe Asp His Gly Gly Thr Val Phe Phe Ser Leu Phe Met Ala Leu 
            420                 425                 430         


Trp Ala Val Leu Leu Leu Glu Tyr Trp Lys Arg Lys Ser Ala Thr Leu 
        435                 440                 445             


Ala Tyr Arg Trp Asp Cys Ser Asp Tyr Glu Asp Thr Glu Glu Arg Pro 
    450                 455                 460                 


Arg Pro Gln Phe Ala Ala Ser Ala Pro Met Thr Ala Pro Asn Pro Ile 
465                 470                 475                 480 


Thr Gly Glu Asp Glu Pro Tyr Phe Pro Glu Arg Ser Arg Ala Arg Arg 
                485                 490                 495     


Met Leu Ala Gly Ser Val Val Ile Val Val Met Val Ala Val Val Val 
            500                 505                 510         


Met Cys Leu Val Ser Ile Ile Leu Tyr Arg Ala Ile Met Ala Ile Val 
        515                 520                 525             


Val Ser Arg Ser Gly Asn Thr Leu Leu Ala Ala Trp Ala Ser Arg Ile 
    530                 535                 540                 


Ala Ser Leu Thr Gly Ser Val Val Asn Leu Val Phe Ile Leu Ile Leu 
545                 550                 555                 560 


Ser Lys Ile Tyr Val Ser Leu Ala His Val Leu Thr Arg Trp Glu Met 
                565                 570                 575     


His Arg Thr Gln Thr Lys Phe Glu Asp Ala Phe Thr Leu Lys Val Phe 
            580                 585                 590         


Ile Phe Gln Phe Val Asn Phe Tyr Ser Ser Pro Val Tyr Ile Ala Phe 
        595                 600                 605             


Phe Lys Gly Arg Phe Val Gly Tyr Pro Gly Asn Tyr His Thr Leu Phe 
    610                 615                 620                 


Gly Val Arg Asn Glu Glu Cys Ala Ala Gly Gly Cys Leu Ile Glu Leu 
625                 630                 635                 640 


Ala Gln Glu Leu Leu Val Ile Met Val Gly Lys Gln Val Ile Asn Asn 
                645                 650                 655     


Met Gln Glu Val Leu Ile Pro Lys Leu Lys Gly Trp Trp Gln Lys Phe 
            660                 665                 670         


Arg Leu Arg Ser Lys Lys Arg Lys Ala Gly Ala Ser Ala Gly Ala Ser 
        675                 680                 685             


Gln Gly Pro Trp Glu Asp Asp Tyr Glu Leu Val Pro Cys Glu Gly Leu 
    690                 695                 700                 


Phe Asp Glu Tyr Leu Glu Met Val Leu Gln Phe Gly Phe Val Thr Ile 
705                 710                 715                 720 


Phe Val Ala Ala Cys Pro Leu Ala Pro Leu Phe Ala Leu Leu Asn Asn 
                725                 730                 735     


Trp Val Glu Ile Arg Leu Asp Ala Arg Lys Phe Val Cys Glu Tyr Arg 
            740                 745                 750         


Arg Pro Val Ala Glu Arg Ala Gln Asp Ile Gly Ile Trp Phe His Ile 
        755                 760                 765             


Leu Ala Gly Leu Thr His Leu Ala Val Ile Ser Asn Ala Phe Leu Leu 
    770                 775                 780                 


Ala Phe Ser Ser Asp Phe Leu Pro Arg Ala Tyr Tyr Arg Trp Thr Arg 
785                 790                 795                 800 


Ala His Asp Leu Arg Gly Phe Leu Asn Phe Thr Leu Ala Arg Ala Pro 
                805                 810                 815     


Ser Ser Phe Ala Ala Ala His Asn Arg Thr Cys Arg Tyr Arg Ala Phe 
            820                 825                 830         


Arg Asp Asp Asp Gly His Tyr Ser Gln Thr Tyr Trp Asn Leu Leu Ala 
        835                 840                 845             


Ile Arg Leu Ala Phe Val Ile Val Phe Glu His Val Val Phe Ser Val 
    850                 855                 860                 


Gly Arg Leu Leu Asp Leu Leu Val Pro Asp Ile Pro Glu Ser Val Glu 
865                 870                 875                 880 


Ile Lys Val Lys Arg Glu Tyr Tyr Leu Ala Lys Gln Ala Leu Ala Glu 
                885                 890                 895     


Asn Glu Val Leu Phe Gly Thr Asn Gly Thr Lys Asp Glu Gln Pro Glu 
            900                 905                 910         


Gly Ser Glu Leu Ser Ser His Trp Thr Pro Phe Thr Val Pro Lys Ala 
        915                 920                 925             


Ser Gln Leu Gln Gln 
    930             


<210>  379
<211>  1270
<212>  PRT
<213>  Homo sapiens

<400>  379

Met Thr Asp Asp Asn Ser Asp Asp Lys Ile Glu Asp Glu Leu Gln Thr 
1               5                   10                  15      


Phe Phe Thr Ser Asp Lys Asp Gly Asn Thr His Ala Tyr Asn Pro Lys 
            20                  25                  30          


Ser Pro Pro Thr Gln Asn Ser Ser Ala Ser Ser Val Asn Trp Asn Ser 
        35                  40                  45              


Ala Asn Pro Asp Asp Met Val Val Asp Tyr Glu Thr Asp Pro Ala Val 
    50                  55                  60                  


Val Thr Gly Glu Asn Ile Ser Leu Ser Leu Gln Gly Val Glu Val Phe 
65                  70                  75                  80  


Gly His Glu Lys Ser Ser Ser Asp Phe Ile Ser Lys Gln Val Leu Asp 
                85                  90                  95      


Met His Lys Asp Ser Ile Cys Gln Cys Pro Ala Leu Val Gly Thr Glu 
            100                 105                 110         


Lys Pro Lys Tyr Leu Gln His Ser Cys His Ser Leu Glu Ala Val Glu 
        115                 120                 125             


Gly Gln Ser Val Glu Pro Ser Leu Pro Phe Val Trp Lys Pro Asn Asp 
    130                 135                 140                 


Asn Leu Asn Cys Ala Gly Tyr Cys Asp Ala Leu Glu Leu Asn Gln Thr 
145                 150                 155                 160 


Phe Asp Met Thr Val Asp Lys Val Asn Cys Thr Phe Ile Ser His His 
                165                 170                 175     


Ala Ile Gly Lys Ser Gln Ser Phe His Thr Ala Gly Ser Leu Pro Pro 
            180                 185                 190         


Thr Gly Arg Arg Ser Gly Ser Thr Ser Ser Leu Ser Tyr Ser Thr Trp 
        195                 200                 205             


Thr Ser Ser His Ser Asp Lys Thr His Ala Arg Glu Thr Thr Tyr Asp 
    210                 215                 220                 


Arg Glu Ser Phe Glu Asn Pro Gln Val Thr Pro Ser Glu Ala Gln Asp 
225                 230                 235                 240 


Met Thr Tyr Thr Ala Phe Ser Asp Val Val Met Gln Ser Glu Val Phe 
                245                 250                 255     


Val Ser Asp Ile Gly Asn Gln Cys Ala Cys Ser Ser Gly Lys Val Thr 
            260                 265                 270         


Ser Glu Tyr Thr Asp Gly Ser Gln Gln Arg Leu Val Gly Glu Lys Glu 
        275                 280                 285             


Thr Gln Ala Leu Thr Pro Val Ser Asp Gly Met Glu Val Pro Asn Asp 
    290                 295                 300                 


Ser Ala Leu Gln Glu Phe Phe Cys Leu Ser His Asp Glu Ser Asn Ser 
305                 310                 315                 320 


Glu Pro His Ser Gln Ser Ser Tyr Arg His Lys Glu Met Gly Gln Asn 
                325                 330                 335     


Leu Arg Glu Thr Val Ser Tyr Cys Leu Ile Asp Asp Glu Cys Pro Leu 
            340                 345                 350         


Met Val Pro Ala Phe Asp Lys Ser Glu Ala Gln Val Leu Asn Pro Glu 
        355                 360                 365             


His Lys Val Thr Glu Thr Glu Asp Thr Gln Met Val Ser Lys Gly Lys 
    370                 375                 380                 


Asp Leu Gly Thr Gln Asn His Thr Ser Glu Leu Ile Leu Ser Ser Pro 
385                 390                 395                 400 


Pro Gly Gln Lys Val Gly Ser Ser Phe Gly Leu Thr Trp Asp Ala Asn 
                405                 410                 415     


Asp Met Val Ile Ser Thr Asp Lys Thr Met Cys Met Ser Thr Pro Val 
            420                 425                 430         


Leu Glu Pro Thr Lys Val Thr Phe Ser Val Ser Pro Ile Glu Ala Thr 
        435                 440                 445             


Glu Lys Cys Lys Lys Val Glu Lys Gly Asn Arg Gly Leu Lys Asn Ile 
    450                 455                 460                 


Pro Asp Ser Lys Glu Ala Pro Val Asn Leu Cys Lys Pro Ser Leu Gly 
465                 470                 475                 480 


Lys Ser Thr Ile Lys Thr Asn Thr Pro Ile Gly Cys Lys Val Arg Lys 
                485                 490                 495     


Thr Glu Ile Ile Ser Tyr Pro Arg Pro Asn Phe Lys Asn Val Lys Ala 
            500                 505                 510         


Lys Val Met Ser Arg Ala Val Leu Gln Pro Lys Asp Ala Ala Leu Ser 
        515                 520                 525             


Lys Val Thr Pro Arg Pro Gln Gln Thr Ser Ala Ser Ser Pro Ser Ser 
    530                 535                 540                 


Val Asn Ser Arg Gln Gln Thr Val Leu Ser Arg Thr Pro Arg Ser Asp 
545                 550                 555                 560 


Leu Asn Ala Asp Lys Lys Ala Glu Ile Leu Ile Asn Lys Thr His Lys 
                565                 570                 575     


Gln Gln Phe Asn Lys Leu Ile Thr Ser Gln Ala Val His Val Thr Thr 
            580                 585                 590         


His Ser Lys Asn Ala Ser His Arg Val Pro Arg Thr Thr Ser Ala Val 
        595                 600                 605             


Lys Ser Asn Gln Glu Asp Val Asp Lys Ala Ser Ser Ser Asn Ser Ala 
    610                 615                 620                 


Cys Glu Thr Gly Ser Val Ser Ala Leu Phe Gln Lys Ile Lys Gly Ile 
625                 630                 635                 640 


Leu Pro Val Lys Met Glu Ser Ala Glu Cys Leu Glu Met Thr Tyr Val 
                645                 650                 655     


Pro Asn Ile Asp Arg Ile Ser Pro Glu Lys Lys Gly Glu Lys Glu Asn 
            660                 665                 670         


Gly Thr Ser Met Glu Lys Gln Glu Leu Lys Gln Glu Ile Met Asn Glu 
        675                 680                 685             


Thr Phe Glu Tyr Gly Ser Leu Phe Leu Gly Ser Ala Ser Lys Thr Thr 
    690                 695                 700                 


Thr Thr Ser Gly Arg Asn Ile Ser Lys Pro Asp Ser Cys Gly Leu Arg 
705                 710                 715                 720 


Gln Ile Ala Ala Pro Lys Ala Lys Val Gly Pro Pro Val Ser Cys Leu 
                725                 730                 735     


Arg Arg Asn Ser Asp Asn Arg Asn Pro Ser Ala Asp Arg Ala Val Ser 
            740                 745                 750         


Pro Gln Arg Ile Arg Arg Val Ser Ser Ser Gly Lys Pro Thr Ser Leu 
        755                 760                 765             


Lys Thr Ala Gln Ser Ser Trp Val Asn Leu Pro Arg Pro Leu Pro Lys 
    770                 775                 780                 


Ser Lys Ala Ser Leu Lys Ser Pro Ala Leu Arg Arg Thr Gly Ser Thr 
785                 790                 795                 800 


Pro Ser Ile Ala Ser Thr His Ser Glu Leu Ser Thr Tyr Ser Asn Asn 
                805                 810                 815     


Ser Gly Asn Ala Ala Val Ile Lys Tyr Glu Glu Lys Pro Pro Lys Pro 
            820                 825                 830         


Ala Phe Gln Asn Gly Ser Ser Gly Ser Phe Tyr Leu Lys Pro Leu Val 
        835                 840                 845             


Ser Arg Ala His Val His Leu Met Lys Thr Pro Pro Lys Gly Pro Ser 
    850                 855                 860                 


Arg Lys Asn Leu Phe Thr Ala Leu Asn Ala Val Glu Lys Ser Arg Gln 
865                 870                 875                 880 


Lys Asn Pro Arg Ser Leu Cys Ile Gln Pro Gln Thr Ala Pro Asp Ala 
                885                 890                 895     


Leu Pro Pro Glu Lys Thr Leu Glu Leu Thr Gln Tyr Lys Thr Lys Cys 
            900                 905                 910         


Glu Asn Gln Ser Gly Phe Ile Leu Gln Leu Lys Gln Leu Leu Ala Cys 
        915                 920                 925             


Gly Asn Thr Lys Phe Glu Ala Leu Thr Val Val Ile Gln His Leu Leu 
    930                 935                 940                 


Ser Glu Arg Glu Glu Ala Leu Lys Gln His Lys Thr Leu Ser Gln Glu 
945                 950                 955                 960 


Leu Val Asn Leu Arg Gly Glu Leu Val Thr Ala Ser Thr Thr Cys Glu 
                965                 970                 975     


Lys Leu Glu Lys Ala Arg Asn Glu Leu Gln Thr Val Tyr Glu Ala Phe 
            980                 985                 990         


Val Gln Gln His Gln Ala Glu Lys  Thr Glu Arg Glu Asn  Arg Leu Lys 
        995                 1000                 1005             


Glu Phe  Tyr Thr Arg Glu Tyr  Glu Lys Leu Arg Asp  Thr Tyr Ile 
    1010                 1015                 1020             


Glu Glu  Ala Glu Lys Tyr Lys  Met Gln Leu Gln Glu  Gln Phe Asp 
    1025                 1030                 1035             


Asn Leu  Asn Ala Ala His Glu  Thr Ser Lys Leu Glu  Ile Glu Ala 
    1040                 1045                 1050             


Ser His  Ser Glu Lys Leu Glu  Leu Leu Lys Lys Ala  Tyr Glu Ala 
    1055                 1060                 1065             


Ser Leu  Ser Glu Ile Lys Lys  Gly His Glu Ile Glu  Lys Lys Ser 
    1070                 1075                 1080             


Leu Glu  Asp Leu Leu Ser Glu  Lys Gln Glu Ser Leu  Glu Lys Gln 
    1085                 1090                 1095             


Ile Asn  Asp Leu Lys Ser Glu  Asn Asp Ala Leu Asn  Glu Lys Leu 
    1100                 1105                 1110             


Lys Ser  Glu Glu Gln Lys Arg  Arg Ala Arg Glu Lys  Ala Asn Leu 
    1115                 1120                 1125             


Lys Asn  Pro Gln Ile Met Tyr  Leu Glu Gln Glu Leu  Glu Ser Leu 
    1130                 1135                 1140             


Lys Ala  Val Leu Glu Ile Lys  Asn Glu Lys Leu His  Gln Gln Asp 
    1145                 1150                 1155             


Ile Lys  Leu Met Lys Met Glu  Lys Leu Val Asp Asn  Asn Thr Ala 
    1160                 1165                 1170             


Leu Val  Asp Lys Leu Lys Arg  Phe Gln Gln Glu Asn  Glu Glu Leu 
    1175                 1180                 1185             


Lys Ala  Arg Met Asp Lys His  Met Ala Ile Ser Arg  Gln Leu Ser 
    1190                 1195                 1200             


Thr Glu  Gln Ala Val Leu Gln  Glu Ser Leu Glu Lys  Glu Ser Lys 
    1205                 1210                 1215             


Val Asn  Lys Arg Leu Ser Met  Glu Asn Glu Glu Leu  Leu Trp Lys 
    1220                 1225                 1230             


Leu His  Asn Gly Asp Leu Cys  Ser Pro Lys Arg Ser  Pro Thr Ser 
    1235                 1240                 1245             


Ser Ala  Ile Pro Leu Gln Ser  Pro Arg Asn Ser Gly  Ser Phe Pro 
    1250                 1255                 1260             


Ser Pro  Ser Ile Ser Pro Arg  
    1265                 1270 


<210>  380
<211>  1216
<212>  PRT
<213>  Homo sapiens

<400>  380

Met Thr Asp Asp Asn Ser Asp Asp Lys Ile Glu Asp Glu Leu Gln Thr 
1               5                   10                  15      


Phe Phe Thr Ser Asp Lys Asp Gly Asn Thr His Ala Tyr Asn Pro Lys 
            20                  25                  30          


Ser Pro Pro Thr Gln Asn Ser Ser Ala Ser Ser Val Asn Trp Asn Ser 
        35                  40                  45              


Ala Asn Pro Asp Asp Met Val Val Asp Tyr Glu Thr Asp Pro Ala Val 
    50                  55                  60                  


Val Thr Gly Glu Asn Ile Ser Leu Ser Leu Gln Gly Val Glu Val Phe 
65                  70                  75                  80  


Gly His Glu Lys Ser Ser Ser Asp Phe Ile Ser Lys Gln Val Leu Asp 
                85                  90                  95      


Met His Lys Asp Ser Ile Cys Gln Cys Pro Ala Leu Val Gly Thr Glu 
            100                 105                 110         


Lys Pro Lys Tyr Leu Gln His Ser Cys His Ser Leu Glu Ala Val Glu 
        115                 120                 125             


Gly Gln Ser Val Glu Pro Ser Leu Pro Phe Val Trp Lys Pro Asn Asp 
    130                 135                 140                 


Asn Leu Asn Cys Ala Gly Tyr Cys Asp Ala Leu Glu Leu Asn Gln Thr 
145                 150                 155                 160 


Phe Asp Met Thr Val Asp Lys Val Asn Cys Thr Phe Ile Ser His His 
                165                 170                 175     


Ala Ile Gly Lys Ser Gln Ser Phe His Thr Ala Gly Ser Leu Pro Pro 
            180                 185                 190         


Thr Gly Arg Arg Ser Gly Ser Thr Ser Ser Leu Ser Tyr Ser Thr Trp 
        195                 200                 205             


Thr Ser Ser His Ser Asp Lys Thr His Ala Arg Glu Thr Thr Tyr Asp 
    210                 215                 220                 


Arg Glu Ser Phe Glu Asn Pro Gln Val Thr Pro Ser Glu Ala Gln Asp 
225                 230                 235                 240 


Met Thr Tyr Thr Ala Phe Ser Asp Val Val Met Gln Ser Glu Val Phe 
                245                 250                 255     


Val Ser Asp Ile Gly Asn Gln Cys Ala Cys Ser Ser Gly Lys Val Thr 
            260                 265                 270         


Ser Glu Tyr Thr Asp Gly Ser Gln Gln Arg Leu Val Gly Glu Lys Glu 
        275                 280                 285             


Thr Gln Ala Leu Thr Pro Val Ser Asp Gly Met Glu Val Pro Asn Asp 
    290                 295                 300                 


Ser Ala Leu Gln Glu Phe Phe Cys Leu Ser His Asp Glu Ser Asn Ser 
305                 310                 315                 320 


Glu Pro His Ser Gln Ser Ser Tyr Arg His Lys Glu Met Gly Gln Asn 
                325                 330                 335     


Leu Arg Glu Thr Val Ser Tyr Cys Leu Ile Asp Asp Glu Cys Pro Leu 
            340                 345                 350         


Met Val Pro Ala Phe Asp Lys Ser Glu Ala Gln Val Leu Asn Pro Glu 
        355                 360                 365             


His Lys Val Thr Glu Thr Glu Asp Thr Gln Met Val Ser Lys Gly Lys 
    370                 375                 380                 


Asp Leu Gly Thr Gln Asn His Thr Ser Glu Leu Ile Leu Ser Ser Pro 
385                 390                 395                 400 


Pro Gly Gln Lys Val Gly Ser Ser Phe Gly Leu Thr Trp Asp Ala Asn 
                405                 410                 415     


Asp Met Val Ile Ser Thr Asp Lys Thr Met Cys Met Ser Thr Pro Val 
            420                 425                 430         


Leu Glu Pro Thr Lys Val Thr Phe Ser Val Ser Pro Ile Glu Ala Thr 
        435                 440                 445             


Glu Lys Cys Lys Lys Val Glu Lys Gly Asn Arg Gly Leu Lys Asn Ile 
    450                 455                 460                 


Pro Asp Ser Lys Glu Ala Pro Val Asn Leu Cys Lys Pro Ser Leu Gly 
465                 470                 475                 480 


Lys Ser Thr Ile Lys Thr Asn Thr Pro Ile Gly Cys Lys Val Arg Lys 
                485                 490                 495     


Thr Glu Ile Ile Ser Tyr Pro Arg Pro Asn Phe Lys Asn Val Lys Ala 
            500                 505                 510         


Lys Val Met Ser Arg Ala Val Leu Gln Pro Lys Asp Ala Ala Leu Ser 
        515                 520                 525             


Lys Val Thr Pro Arg Pro Gln Gln Thr Ser Ala Ser Ser Pro Ser Ser 
    530                 535                 540                 


Val Asn Ser Arg Gln Gln Thr Val Leu Ser Arg Thr Pro Arg Ser Asp 
545                 550                 555                 560 


Leu Asn Ala Asp Lys Lys Ala Glu Ile Leu Ile Asn Lys Thr His Lys 
                565                 570                 575     


Gln Gln Phe Asn Lys Leu Ile Thr Ser Gln Ala Val His Val Thr Thr 
            580                 585                 590         


His Ser Lys Asn Ala Ser His Arg Val Pro Arg Thr Thr Ser Ala Val 
        595                 600                 605             


Lys Ser Asn Gln Glu Asp Val Asp Lys Ala Ser Ser Ser Asn Ser Ala 
    610                 615                 620                 


Cys Glu Thr Gly Ser Val Ser Ala Leu Phe Gln Lys Ile Lys Gly Ile 
625                 630                 635                 640 


Leu Pro Val Lys Met Glu Ser Ala Glu Cys Leu Glu Met Thr Tyr Val 
                645                 650                 655     


Pro Asn Ile Asp Arg Ile Ser Pro Glu Lys Lys Gly Glu Lys Glu Asn 
            660                 665                 670         


Gly Thr Ser Met Glu Lys Gln Glu Leu Lys Gln Glu Ile Met Asn Glu 
        675                 680                 685             


Thr Phe Glu Tyr Gly Ser Leu Phe Leu Gly Ser Ala Ser Lys Thr Thr 
    690                 695                 700                 


Thr Thr Ser Gly Arg Asn Ile Ser Lys Pro Asp Ser Cys Gly Leu Arg 
705                 710                 715                 720 


Gln Ile Ala Ala Pro Lys Ala Lys Val Gly Pro Pro Val Ser Cys Leu 
                725                 730                 735     


Arg Arg Asn Ser Asp Asn Arg Asn Pro Ser Ala Asp Arg Ala Val Ser 
            740                 745                 750         


Pro Gln Arg Ile Arg Arg Val Ser Ser Ser Ala Gly Asn Ala Ala Val 
        755                 760                 765             


Ile Lys Tyr Glu Glu Lys Pro Pro Lys Pro Ala Phe Gln Asn Gly Ser 
    770                 775                 780                 


Ser Gly Ser Phe Tyr Leu Lys Pro Leu Val Ser Arg Ala His Val His 
785                 790                 795                 800 


Leu Met Lys Thr Pro Pro Lys Gly Pro Ser Arg Lys Asn Leu Phe Thr 
                805                 810                 815     


Ala Leu Asn Ala Val Glu Lys Ser Arg Gln Lys Asn Pro Arg Ser Leu 
            820                 825                 830         


Cys Ile Gln Pro Gln Thr Ala Pro Asp Ala Leu Pro Pro Glu Lys Thr 
        835                 840                 845             


Leu Glu Leu Thr Gln Tyr Lys Thr Lys Cys Glu Asn Gln Ser Gly Phe 
    850                 855                 860                 


Ile Leu Gln Leu Lys Gln Leu Leu Ala Cys Gly Asn Thr Lys Phe Glu 
865                 870                 875                 880 


Ala Leu Thr Val Val Ile Gln His Leu Leu Ser Glu Arg Glu Glu Ala 
                885                 890                 895     


Leu Lys Gln His Lys Thr Leu Ser Gln Glu Leu Val Asn Leu Arg Gly 
            900                 905                 910         


Glu Leu Val Thr Ala Ser Thr Thr Cys Glu Lys Leu Glu Lys Ala Arg 
        915                 920                 925             


Asn Glu Leu Gln Thr Val Tyr Glu Ala Phe Val Gln Gln His Gln Ala 
    930                 935                 940                 


Glu Lys Thr Glu Arg Glu Asn Arg Leu Lys Glu Phe Tyr Thr Arg Glu 
945                 950                 955                 960 


Tyr Glu Lys Leu Arg Asp Thr Tyr Ile Glu Glu Ala Glu Lys Tyr Lys 
                965                 970                 975     


Met Gln Leu Gln Glu Gln Phe Asp Asn Leu Asn Ala Ala His Glu Thr 
            980                 985                 990         


Ser Lys Leu Glu Ile Glu Ala Ser  His Ser Glu Lys Leu  Glu Leu Leu 
        995                 1000                 1005             


Lys Lys  Ala Tyr Glu Ala Ser  Leu Ser Glu Ile Lys  Lys Gly His 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ser Leu  Glu Asp Leu Leu Ser  Glu Lys Gln 
    1025                 1030                 1035             


Glu Ser  Leu Glu Lys Gln Ile  Asn Asp Leu Lys Ser  Glu Asn Asp 
    1040                 1045                 1050             


Ala Leu  Asn Glu Lys Leu Lys  Ser Glu Glu Gln Lys  Arg Arg Ala 
    1055                 1060                 1065             


Arg Glu  Lys Ala Asn Leu Lys  Asn Pro Gln Ile Met  Tyr Leu Glu 
    1070                 1075                 1080             


Gln Glu  Leu Glu Ser Leu Lys  Ala Val Leu Glu Ile  Lys Asn Glu 
    1085                 1090                 1095             


Lys Leu  His Gln Gln Asp Ile  Lys Leu Met Lys Met  Glu Lys Leu 
    1100                 1105                 1110             


Val Asp  Asn Asn Thr Ala Leu  Val Asp Lys Leu Lys  Arg Phe Gln 
    1115                 1120                 1125             


Gln Glu  Asn Glu Glu Leu Lys  Ala Arg Met Asp Lys  His Met Ala 
    1130                 1135                 1140             


Ile Ser  Arg Gln Leu Ser Thr  Glu Gln Ala Val Leu  Gln Glu Ser 
    1145                 1150                 1155             


Leu Glu  Lys Glu Ser Lys Val  Asn Lys Arg Leu Ser  Met Glu Asn 
    1160                 1165                 1170             


Glu Glu  Leu Leu Trp Lys Leu  His Asn Gly Asp Leu  Cys Ser Pro 
    1175                 1180                 1185             


Lys Arg  Ser Pro Thr Ser Ser  Ala Ile Pro Leu Gln  Ser Pro Arg 
    1190                 1195                 1200             


Asn Ser  Gly Ser Phe Pro Ser  Pro Ser Ile Ser Pro  Arg 
    1205                 1210                 1215     


<210>  381
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  381

Met Thr Val Pro Gly Gly Phe Arg Ser Cys Thr Glu Thr Asp Ile Ser 
1               5                   10                  15      


Ser Lys Ile Phe Ile Asn Ser Thr Leu Thr Pro Pro Ala Gly Ser Glu 
            20                  25                  30          


Arg His Tyr Asp Ala Thr Leu Leu Thr Leu Leu Val Val Gly Ser Tyr 
        35                  40                  45              


Ser Leu Cys Ile Ile Pro Leu Leu Ala Thr Phe Thr Gly Lys Lys Thr 
    50                  55                  60                  


Gly Asn Ala Ala Val Ile Lys Tyr Glu Glu Lys Pro Pro Lys Pro Ala 
65                  70                  75                  80  


Phe Gln Asn Gly Ser Ser Gly Ser Phe Tyr Leu Lys Pro Leu Val Ser 
                85                  90                  95      


Arg Ala His Val His Leu Met Lys Thr Pro Pro Lys Gly Pro Ser Arg 
            100                 105                 110         


Lys Asn Leu Phe Thr Ala Leu Asn Ala Val Glu Lys Ser Arg Gln Lys 
        115                 120                 125             


Asn Pro Arg Ser Leu Cys Ile Gln Pro Gln Thr Ala Pro Asp Ala Leu 
    130                 135                 140                 


Pro Pro Glu Lys Thr Leu Glu Leu Thr Gln Tyr Lys Thr Lys Cys Glu 
145                 150                 155                 160 


Asn Gln Ser Gly Phe Ile Leu Gln Leu Lys Gln Leu Leu Ala Cys Gly 
                165                 170                 175     


Asn Thr Lys Phe Glu Ala Leu Thr Val Val Ile Gln His Leu Leu Ser 
            180                 185                 190         


Glu Arg Glu Glu Ala Leu Lys Gln His Lys Thr Leu Ser Gln Glu Leu 
        195                 200                 205             


Val Asn Leu Arg Gly Glu Leu Val Thr Ala Ser Thr Thr Cys Glu Lys 
    210                 215                 220                 


Leu Glu Lys Ala Arg Asn Glu Leu Gln Thr Val Tyr Glu Ala Phe Val 
225                 230                 235                 240 


Gln Gln His Gln Ala Glu Lys Thr Glu Arg Glu Asn Arg Leu Lys Glu 
                245                 250                 255     


Phe Tyr Thr Arg Glu Tyr Glu Lys Leu Arg Asp Thr Tyr Ile Glu Glu 
            260                 265                 270         


Ala Glu Lys Tyr Lys Met Gln Leu Gln Glu Gln Phe Asp Asn Leu Asn 
        275                 280                 285             


Ala Ala His Glu Thr Ser Lys Leu Glu Ile Glu Ala Ser His Ser Glu 
    290                 295                 300                 


Lys Leu Glu Leu Leu Lys Lys Ala Tyr Glu Ala Ser Leu Ser Glu Ile 
305                 310                 315                 320 


Lys Lys Gly His Glu Ile Glu Lys Lys Ser Leu Glu Asp Leu Leu Ser 
                325                 330                 335     


Glu Lys Gln Glu Ser Leu Glu Lys Gln Ile Asn Asp Leu Lys Ser Glu 
            340                 345                 350         


Asn Asp Ala Leu Asn Glu Lys Leu Lys Ser Glu Glu Gln Lys Arg Arg 
        355                 360                 365             


Ala Arg Glu Lys Ala Asn Leu Lys Asn Pro Gln Ile Met Tyr Leu Glu 
    370                 375                 380                 


Gln Glu Leu Glu Ser Leu Lys Ala Val Leu Glu Ile Lys Asn Glu Lys 
385                 390                 395                 400 


Leu His Gln Gln Asp Ile Lys Leu Met Lys Met Glu Lys Leu Val Asp 
                405                 410                 415     


Asn Asn Thr Ala Leu Val Asp Lys Leu Lys Arg Phe Gln Gln Glu Asn 
            420                 425                 430         


Glu Glu Leu Lys Ala Arg Met Asp Lys His Met Ala Ile Ser Arg Gln 
        435                 440                 445             


Leu Ser Thr Glu Gln Ala Val Leu Gln Glu Ser Leu Glu Lys Glu Ser 
    450                 455                 460                 


Lys Val Asn Lys Arg Leu Ser Met Glu Asn Glu Glu Leu Leu Trp Lys 
465                 470                 475                 480 


Leu His Asn Gly Asp Leu Cys Ser Pro Lys Arg Ser Pro Thr Ser Ser 
                485                 490                 495     


Ala Ile Pro Leu Gln Ser Pro Arg Asn Ser Gly Ser Phe Pro Ser Pro 
            500                 505                 510         


Ser Ile Ser Pro Arg 
        515         


<210>  382
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  382

Met Gly Cys Phe Glu Cys Cys Ile Lys Cys Leu Gly Gly Val Pro Tyr 
1               5                   10                  15      


Ala Ser Leu Val Ala Thr Ile Leu Cys Phe Ser Gly Val Ala Leu Phe 
            20                  25                  30          


Cys Gly Cys Gly His Val Ala Leu Ala Gly Thr Val Ala Ile Leu Glu 
        35                  40                  45              


Gln His Phe Ser Thr Asn Ala Ser Asp His Ala Leu Leu Ser Glu Val 
    50                  55                  60                  


Ile Gln Leu Met Gln Tyr Val Ile Tyr Gly Ile Ala Ser Phe Phe Phe 
65                  70                  75                  80  


Leu Tyr Gly Ile Ile Leu Leu Ala Glu Gly Phe Tyr Thr Thr Ser Ala 
                85                  90                  95      


Val Lys Glu Leu His Gly Glu Phe Lys Thr Thr Ala Cys Gly Arg Cys 
            100                 105                 110         


Ile Ser Gly Met Phe Val Phe Leu Thr Tyr Val Leu Gly Val Ala Trp 
        115                 120                 125             


Leu Gly Val Phe Gly Phe Ser Ala Val Pro Val Phe Met Phe Tyr Asn 
    130                 135                 140                 


Ile Trp Ser Thr Cys Glu Val Ile Lys Ser Pro Gln Thr Asn Gly Thr 
145                 150                 155                 160 


Thr Gly Val Glu Gln Ile Cys Val Asp Ile Arg Gln Tyr Gly Ile Ile 
                165                 170                 175     


Pro Trp Asn Ala Phe Pro Gly Lys Ile Cys Gly Ser Ala Leu Glu Asn 
            180                 185                 190         


Ile Cys Asn Thr Asn Glu Phe Tyr Met Ser Tyr His Leu Phe Ile Val 
        195                 200                 205             


Ala Cys Ala Gly Ala Gly Ala Thr Val Ile Ala Leu Leu Ile Tyr Met 
    210                 215                 220                 


Met Ala Thr Thr Tyr Asn Tyr Ala Val Leu Lys Phe Lys Ser Arg Glu 
225                 230                 235                 240 


Asp Cys Cys Thr Lys Phe 
                245     


<210>  383
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  383

Met Lys Pro Ala Met Glu Thr Ala Ala Glu Glu Asn Thr Glu Gln Ser 
1               5                   10                  15      


Gln Glu Arg Lys Val Asn Ser Arg Ala Glu Met Glu Ile Gly Arg Tyr 
            20                  25                  30          


His Trp Met Tyr Pro Gly Ser Lys Asn His Gln Tyr His Pro Val Pro 
        35                  40                  45              


Thr Leu Gly Asp Arg Ala Ser Pro Leu Ser Ser Pro Gly Cys Phe Glu 
    50                  55                  60                  


Cys Cys Ile Lys Cys Leu Gly Gly Val Pro Tyr Ala Ser Leu Val Ala 
65                  70                  75                  80  


Thr Ile Leu Cys Phe Ser Gly Val Ala Leu Phe Cys Gly Cys Gly His 
                85                  90                  95      


Val Ala Leu Ala Gly Thr Val Ala Ile Leu Glu Gln His Phe Ser Thr 
            100                 105                 110         


Asn Ala Ser Asp His Ala Leu Leu Ser Glu Val Ile Gln Leu Met Gln 
        115                 120                 125             


Tyr Val Ile Tyr Gly Ile Ala Ser Phe Phe Phe Leu Tyr Gly Ile Ile 
    130                 135                 140                 


Leu Leu Ala Glu Gly Phe Tyr Thr Thr Ser Ala Val Lys Glu Leu His 
145                 150                 155                 160 


Gly Glu Phe Lys Thr Thr Ala Cys Gly Arg Cys Ile Ser Gly Met Phe 
                165                 170                 175     


Val Phe Leu Thr Tyr Val Leu Gly Val Ala Trp Leu Gly Val Phe Gly 
            180                 185                 190         


Phe Ser Ala Val Pro Val Phe Met Phe Tyr Asn Ile Trp Ser Thr Cys 
        195                 200                 205             


Glu Val Ile Lys Ser Pro Gln Thr Asn Gly Thr Thr Gly Val Glu Gln 
    210                 215                 220                 


Ile Cys Val Asp Ile Arg Gln Tyr Gly Ile Ile Pro Trp Asn Ala Phe 
225                 230                 235                 240 


Pro Gly Lys Ile Cys Gly Ser Ala Leu Glu Asn Ile Cys Asn Thr Asn 
                245                 250                 255     


Glu Phe Tyr Met Ser Tyr His Leu Phe Ile Val Ala Cys Ala Gly Ala 
            260                 265                 270         


Gly Ala Thr Val Ile Ala Leu Ile His Phe Leu Met Ile Leu Ser Ser 
        275                 280                 285             


Asn Trp Ala Tyr Leu Lys Asp Ala Ser Lys Met Gln Ala Tyr Gln Asp 
    290                 295                 300                 


Ile Lys Ala Lys Glu Glu Gln Glu Leu Gln Asp Ile Gln Ser Arg Ser 
305                 310                 315                 320 


Lys Glu Gln Leu Asn Ser Tyr Thr 
                325             


<210>  384
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  384

Met Lys Pro Ala Met Glu Thr Ala Ala Glu Glu Asn Thr Glu Gln Ser 
1               5                   10                  15      


Gln Glu Arg Lys Val Asn Ser Arg Ala Glu Met Glu Ile Gly Arg Tyr 
            20                  25                  30          


His Trp Met Tyr Pro Gly Ser Lys Asn His Gln Tyr His Pro Val Pro 
        35                  40                  45              


Thr Leu Gly Asp Arg Ala Ser Pro Leu Ser Ser Pro Gly Cys Phe Glu 
    50                  55                  60                  


Cys Cys Ile Lys Cys Leu Gly Gly Val Pro Tyr Ala Ser Leu Val Ala 
65                  70                  75                  80  


Thr Ile Leu Cys Phe Ser Gly Val Ala Leu Phe Cys Gly Cys Gly His 
                85                  90                  95      


Val Ala Leu Ala Gly Thr Val Ala Ile Leu Glu Gln His Phe Ser Thr 
            100                 105                 110         


Asn Ala Ser Asp His Ala Leu Leu Ser Glu Val Ile Gln Leu Met Gln 
        115                 120                 125             


Tyr Val Ile Tyr Gly Ile Ala Ser Phe Phe Phe Leu Tyr Gly Ile Ile 
    130                 135                 140                 


Leu Leu Ala Glu Gly Phe Tyr Thr Thr Ser Ala Val Lys Glu Leu His 
145                 150                 155                 160 


Gly Glu Phe Lys Thr Thr Ala Cys Gly Arg Cys Ile Ser Gly Met Phe 
                165                 170                 175     


Val Phe Leu Thr Tyr Val Leu Gly Val Ala Trp Leu Gly Val Phe Gly 
            180                 185                 190         


Phe Ser Ala Val Pro Val Phe Met Phe Tyr Asn Ile Trp Ser Thr Cys 
        195                 200                 205             


Glu Val Ile Lys Ser Pro Gln Thr Asn Gly Thr Thr Gly Val Glu Gln 
    210                 215                 220                 


Ile Cys Val Asp Ile Arg Gln Tyr Gly Ile Ile Pro Trp Asn Ala Phe 
225                 230                 235                 240 


Pro Gly Lys Ile Cys Gly Ser Ala Leu Glu Asn Ile Cys Asn Thr Asn 
                245                 250                 255     


Glu Phe Tyr Met Ser Tyr His Leu Phe Ile Val Ala Cys Ala Gly Ala 
            260                 265                 270         


Gly Ala Thr Val Ile Ala Leu Leu Ile Tyr Met Met Ala Thr Thr Tyr 
        275                 280                 285             


Asn Tyr Ala Val Leu Lys Phe Lys Ser Arg Glu Asp Cys Cys Thr Lys 
    290                 295                 300                 


Phe 
305 


<210>  385
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  385

Met Thr Asn Gln Glu Ser Ala Val His Val Lys Met Met Pro Glu Phe 
1               5                   10                  15      


Gln Lys Ser Ser Val Arg Ile Lys Asn Pro Thr Arg Val Glu Glu Ile 
            20                  25                  30          


Ile Cys Gly Leu Ile Lys Gly Gly Ala Ala Lys Leu Gln Ile Ile Thr 
        35                  40                  45              


Asp Phe Asp Met Thr Leu Ser Arg Phe Ser Tyr Lys Gly Lys Arg Cys 
    50                  55                  60                  


Pro Thr Cys His Asn Ile Ile Asp Asn Cys Lys Leu Val Thr Asp Glu 
65                  70                  75                  80  


Cys Arg Lys Lys Leu Leu Gln Leu Lys Glu Lys Tyr Tyr Ala Ile Glu 
                85                  90                  95      


Val Asp Pro Val Leu Thr Val Glu Glu Lys Tyr Pro Tyr Met Val Glu 
            100                 105                 110         


Trp Tyr Thr Lys Ser His Gly Leu Leu Val Gln Gln Ala Leu Pro Lys 
        115                 120                 125             


Ala Lys Leu Lys Glu Ile Val Ala Glu Ser Asp Val Met Leu Lys Glu 
    130                 135                 140                 


Gly Tyr Glu Asn Phe Phe Asp Lys Leu Gln Gln His Ser Ile Pro Val 
145                 150                 155                 160 


Phe Ile Phe Ser Ala Gly Ile Gly Asp Val Leu Glu Glu Val Ile Arg 
                165                 170                 175     


Gln Ala Gly Val Tyr His Pro Asn Val Lys Val Val Ser Asn Phe Met 
            180                 185                 190         


Asp Phe Asp Glu Thr Gly Val Leu Lys Gly Phe Lys Gly Glu Leu Ile 
        195                 200                 205             


His Val Phe Asn Lys His Asp Gly Ala Leu Arg Asn Thr Glu Tyr Phe 
    210                 215                 220                 


Asn Gln Leu Lys Asp Asn Ser Asn Ile Ile Leu Leu Gly Asp Ser Gln 
225                 230                 235                 240 


Gly Asp Leu Arg Met Ala Asp Gly Val Ala Asn Val Glu His Ile Leu 
                245                 250                 255     


Lys Ile Gly Tyr Leu Asn Asp Arg Val Asp Glu Leu Leu Glu Lys Tyr 
            260                 265                 270         


Met Asp Ser Tyr Asp Ile Val Leu Val Gln Asp Glu Ser Leu Glu Val 
        275                 280                 285             


Ala Asn Ser Ile Leu Gln Lys Ile Leu 
    290                 295         


<210>  386
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  386

Met Arg Ala Pro Ser Met Asp Arg Ala Ala Val Ala Arg Val Gly Ala 
1               5                   10                  15      


Val Ala Ser Ala Ser Val Cys Ala Leu Val Ala Gly Val Val Leu Ala 
            20                  25                  30          


Gln Tyr Ile Phe Thr Leu Lys Arg Lys Thr Gly Arg Lys Thr Lys Ile 
        35                  40                  45              


Ile Glu Met Met Pro Glu Phe Gln Lys Ser Ser Val Arg Ile Lys Asn 
    50                  55                  60                  


Pro Thr Arg Val Glu Glu Ile Ile Cys Gly Leu Ile Lys Gly Gly Ala 
65                  70                  75                  80  


Ala Lys Leu Gln Ile Ile Thr Asp Phe Asp Met Thr Leu Ser Arg Phe 
                85                  90                  95      


Ser Tyr Lys Gly Lys Arg Cys Pro Thr Cys His Asn Ile Ile Asp Asn 
            100                 105                 110         


Cys Lys Leu Val Thr Asp Glu Cys Arg Lys Lys Leu Leu Gln Leu Lys 
        115                 120                 125             


Glu Lys Tyr Tyr Ala Ile Glu Val Asp Pro Val Leu Thr Val Glu Glu 
    130                 135                 140                 


Lys Tyr Pro Tyr Met Val Glu Trp Tyr Thr Lys Ser His Gly Leu Leu 
145                 150                 155                 160 


Val Gln Gln Ala Leu Pro Lys Ala Lys Leu Lys Glu Ile Val Ala Glu 
                165                 170                 175     


Ser Asp Val Met Leu Lys Glu Gly Tyr Glu Asn Phe Phe Asp Lys Leu 
            180                 185                 190         


Gln Gln His Ser Ile Pro Val Phe Ile Phe Ser Ala Gly Ile Gly Asp 
        195                 200                 205             


Val Leu Glu Glu Val Ile Arg Gln Ala Gly Val Tyr His Pro Asn Val 
    210                 215                 220                 


Lys Val Val Ser Asn Phe Met Asp Phe Asp Glu Thr Gly Val Leu Lys 
225                 230                 235                 240 


Gly Phe Lys Gly Glu Leu Ile His Val Phe Asn Lys His Asp Gly Ala 
                245                 250                 255     


Leu Arg Asn Thr Glu Tyr Phe Asn Gln Leu Lys Asp Asn Ser Asn Ile 
            260                 265                 270         


Ile Leu Leu Gly Asp Ser Gln Gly Asp Leu Arg Met Ala Asp Gly Val 
        275                 280                 285             


Ala Asn Val Glu His Ile Leu Lys Ile Gly Tyr Leu Asn Asp Arg Val 
    290                 295                 300                 


Asp Glu Leu Leu Glu Lys Tyr Met Asp Ser Tyr Asp Ile Val Leu Val 
305                 310                 315                 320 


Gln Asp Glu Ser Leu Glu Val Ala Asn Ser Ile Leu Gln Lys Ile Leu 
                325                 330                 335     


<210>  387
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  387

Met Ala Val Thr Ala Cys Gln Gly Leu Gly Phe Val Val Ser Leu Ile 
1               5                   10                  15      


Gly Ile Ala Gly Ile Ile Ala Ala Thr Cys Met Asp Gln Trp Ser Thr 
            20                  25                  30          


Gln Asp Leu Tyr Asn Asn Pro Val Thr Ala Val Phe Asn Tyr Gln Gly 
        35                  40                  45              


Leu Trp Arg Ser Cys Val Arg Glu Ser Ser Gly Phe Thr Glu Cys Arg 
    50                  55                  60                  


Gly Tyr Phe Thr Leu Leu Gly Leu Pro Ala Met Leu Gln Ala Val Arg 
65                  70                  75                  80  


Ala Leu Met Ile Val Gly Ile Val Leu Gly Ala Ile Gly Leu Leu Val 
                85                  90                  95      


Ser Ile Phe Ala Leu Lys Cys Ile Arg Ile Gly Ser Met Glu Asp Ser 
            100                 105                 110         


Ala Lys Ala Asn Met Thr Leu Thr Ser Gly Ile Met Phe Ile Val Ser 
        115                 120                 125             


Gly Leu Cys Ala Ile Ala Gly Val Ser Val Phe Ala Asn Met Leu Val 
    130                 135                 140                 


Thr Asn Phe Trp Met Ser Thr Ala Asn Met Tyr Thr Gly Met Gly Gly 
145                 150                 155                 160 


Met Val Gln Thr Val Gln Thr Arg Tyr Thr Phe Gly Ala Ala Leu Phe 
                165                 170                 175     


Val Gly Trp Val Ala Gly Gly Leu Thr Leu Ile Gly Gly Val Met Met 
            180                 185                 190         


Cys Ile Ala Cys Arg Gly Leu Ala Pro Glu Glu Thr Asn Tyr Lys Ala 
        195                 200                 205             


Val Ser Tyr His Ala Ser Gly His Ser Val Ala Tyr Lys Pro Gly Gly 
    210                 215                 220                 


Phe Lys Ala Ser Thr Gly Phe Gly Ser Asn Thr Lys Asn Lys Lys Ile 
225                 230                 235                 240 


Tyr Asp Gly Gly Ala Arg Thr Glu Asp Glu Val Gln Ser Tyr Pro Ser 
                245                 250                 255     


Lys His Asp Tyr Val 
            260     


<210>  388
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  388

Met Ala Lys Ser Leu Leu Lys Thr Ala Ser Leu Ser Gly Arg Thr Lys 
1               5                   10                  15      


Leu Leu His Gln Thr Gly Leu Ser Leu Tyr Ser Thr Ser His Gly Phe 
            20                  25                  30          


Tyr Glu Glu Glu Val Lys Lys Thr Leu Gln Gln Phe Pro Gly Gly Ser 
        35                  40                  45              


Ile Asp Leu Gln Lys Glu Asp Asn Gly Ile Gly Ile Leu Thr Leu Asn 
    50                  55                  60                  


Asn Pro Ser Arg Met Asn Ala Phe Ser Gly Val Met Met Leu Gln Leu 
65                  70                  75                  80  


Leu Glu Lys Val Ile Glu Leu Glu Asn Trp Thr Glu Gly Lys Gly Leu 
                85                  90                  95      


Ile Val Arg Gly Ala Lys Asn Thr Phe Ser Ser Gly Ser Asp Leu Asn 
            100                 105                 110         


Ala Val Lys Ser Leu Gly Thr Pro Glu Asp Gly Met Ala Val Cys Met 
        115                 120                 125             


Phe Met Gln Asn Thr Leu Thr Arg Phe Met Arg Leu Pro Leu Ile Ser 
    130                 135                 140                 


Val Ala Leu Val Gln Gly Trp Ala Leu Gly Gly Gly Ala Glu Phe Thr 
145                 150                 155                 160 


Thr Ala Cys Asp Phe Arg Leu Met Thr Pro Glu Ser Lys Ile Arg Phe 
                165                 170                 175     


Val His Lys Glu Met Gly Ile Ile Pro Ser Trp Gly Gly Thr Thr Arg 
            180                 185                 190         


Leu Val Glu Ile Ile Gly Ser Arg Gln Ala Leu Lys Val Leu Ser Gly 
        195                 200                 205             


Ala Leu Lys Leu Asp Ser Lys Asn Ala Leu Asn Ile Gly Met Val Glu 
    210                 215                 220                 


Glu Val Leu Gln Ser Ser Asp Glu Thr Lys Ser Leu Glu Glu Ala Gln 
225                 230                 235                 240 


Glu Trp Leu Lys Gln Phe Ile Gln Gly Pro Pro Glu Val Ile Arg Ala 
                245                 250                 255     


Leu Lys Lys Ser Val Cys Ser Gly Arg Glu Leu Tyr Leu Glu Glu Ala 
            260                 265                 270         


Leu Gln Asn Glu Arg Asp Leu Leu Gly Thr Val Trp Gly Gly Pro Ala 
        275                 280                 285             


Asn Leu Glu Ala Ile Ala Lys Lys Gly Lys Phe Asn Lys 
    290                 295                 300     


<210>  389
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  389

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
            20                  25                  30          


Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
        35                  40                  45              


Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
    50                  55                  60                  


Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
65                  70                  75                  80  


Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                85                  90                  95      


His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
            100                 105                 110         


Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
        115                 120                 125             


Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
    130                 135                 140                 


Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
145                 150                 155                 160 


Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                165                 170                 175     


Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
            180                 185                 190         


Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
        195                 200                 205             


Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
    210                 215                 220                 


Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val 
225                 230                 235                 240 


Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                245                 250                 255     


Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
            260                 265                 270         


Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
        275                 280                 285             


Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
    290                 295                 300                 


Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
305                 310                 315                 320 


Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                325                 330                 335     


Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
            340                 345                 350         


Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
        355                 360                 365             


Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
    370                 375                 380                 


Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
385                 390                 395                 400 


Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                405                 410                 415     


Gln Lys 
        


<210>  390
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  390

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
            20                  25                  30          


Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
        35                  40                  45              


Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
    50                  55                  60                  


Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
65                  70                  75                  80  


Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                85                  90                  95      


His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
            100                 105                 110         


Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
        115                 120                 125             


Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
    130                 135                 140                 


Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
145                 150                 155                 160 


Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                165                 170                 175     


Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
            180                 185                 190         


Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
        195                 200                 205             


Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
    210                 215                 220                 


Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val 
225                 230                 235                 240 


Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                245                 250                 255     


Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
            260                 265                 270         


Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
        275                 280                 285             


Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
    290                 295                 300                 


Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
305                 310                 315                 320 


Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                325                 330                 335     


Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
            340                 345                 350         


Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
        355                 360                 365             


Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
    370                 375                 380                 


Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
385                 390                 395                 400 


Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                405                 410                 415     


Gln Lys 
        


<210>  391
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  391

Met Val Ser Trp Lys Gly Ile Tyr Phe Ile Leu Thr Leu Phe Trp Gly 
1               5                   10                  15      


Ser Phe Phe Gly Ser Ile Phe Met Leu Ser Pro Phe Leu Pro Leu Met 
            20                  25                  30          


Phe Val Asn Pro Ser Trp Tyr Arg Trp Ile Asn Asn Arg Leu Val Ala 
        35                  40                  45              


Thr Trp Leu Thr Leu Pro Val Ala Leu Leu Glu Thr Met Phe Gly Val 
    50                  55                  60                  


Lys Val Ile Ile Thr Gly Asp Ala Phe Val Pro Gly Glu Arg Ser Val 
65                  70                  75                  80  


Ile Ile Met Asn His Arg Thr Arg Met Asp Trp Met Phe Leu Trp Asn 
                85                  90                  95      


Cys Leu Met Arg Tyr Ser Tyr Leu Arg Leu Glu Lys Ile Cys Leu Lys 
            100                 105                 110         


Ala Ser Leu Lys Gly Val Pro Gly Phe Gly Trp Ala Met Gln Ala Ala 
        115                 120                 125             


Ala Tyr Ile Phe Ile His Arg Lys Trp Lys Asp Asp Lys Ser His Phe 
    130                 135                 140                 


Glu Asp Met Ile Asp Tyr Phe Cys Asp Ile His Glu Pro Leu Gln Leu 
145                 150                 155                 160 


Leu Ile Phe Pro Glu Gly Thr Asp Leu Thr Glu Asn Ser Lys Ser Arg 
                165                 170                 175     


Ser Asn Ala Phe Ala Glu Lys Asn Gly Leu Gln Lys Tyr Glu Tyr Val 
            180                 185                 190         


Leu His Pro Arg Thr Thr Gly Phe Thr Phe Val Val Asp Arg Leu Arg 
        195                 200                 205             


Glu Gly Lys Asn Leu Asp Ala Val His Asp Ile Thr Val Ala Tyr Pro 
    210                 215                 220                 


His Asn Ile Pro Gln Ser Glu Lys His Leu Leu Gln Gly Asp Phe Pro 
225                 230                 235                 240 


Arg Glu Ile His Phe His Val His Arg Tyr Pro Ile Asp Thr Leu Pro 
                245                 250                 255     


Thr Ser Lys Glu Asp Leu Gln Leu Trp Cys His Lys Arg Trp Glu Glu 
            260                 265                 270         


Lys Glu Glu Arg Leu Arg Ser Phe Tyr Gln Gly Glu Lys Asn Phe Tyr 
        275                 280                 285             


Phe Thr Gly Gln Ser Val Ile Pro Pro Cys Lys Ser Glu Leu Arg Val 
    290                 295                 300                 


Leu Val Val Lys Leu Leu Ser Ile Leu Tyr Trp Thr Leu Phe Ser Pro 
305                 310                 315                 320 


Ala Met Cys Leu Leu Ile Tyr Leu Tyr Ser Leu Val Lys Trp Tyr Phe 
                325                 330                 335     


Ile Ile Thr Ile Val Ile Phe Val Leu Gln Glu Arg Ile Phe Gly Gly 
            340                 345                 350         


Leu Glu Ile Ile Glu Leu Ala Cys Tyr Arg Leu Leu His Lys Gln Pro 
        355                 360                 365             


His Leu Asn Ser Lys Lys Asn Glu 
    370                 375     


<210>  392
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  392

Met Phe Ala Cys Ala Lys Leu Ala Cys Thr Pro Ser Leu Ile Arg Ala 
1               5                   10                  15      


Gly Ser Arg Val Ala Tyr Arg Pro Ile Ser Ala Ser Val Leu Ser Arg 
            20                  25                  30          


Pro Glu Ala Ser Arg Thr Gly Glu Gly Ser Thr Val Phe Asn Gly Ala 
        35                  40                  45              


Gln Asn Gly Val Ser Gln Leu Ile Gln Arg Glu Phe Gln Thr Ser Ala 
    50                  55                  60                  


Ile Ser Arg Asp Ile Asp Thr Ala Ala Lys Phe Ile Gly Ala Gly Ala 
65                  70                  75                  80  


Ala Thr Val Gly Val Ala Gly Ser Gly Ala Gly Ile Gly Thr Val Phe 
                85                  90                  95      


Gly Ser Leu Ile Ile Gly Tyr Ala Arg Asn Pro Ser Leu Lys Gln Gln 
            100                 105                 110         


Leu Phe Ser Tyr Ala Ile Leu Gly Phe Ala Leu Ser Glu Ala Met Gly 
        115                 120                 125             


Leu Phe Cys Leu Met Val Ala Phe Leu Ile Leu Phe Ala Met 
    130                 135                 140         


<210>  393
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  393

Met Gln Thr Ser Glu Arg Glu Gly Ser Gly Pro Glu Leu Ser Pro Ser 
1               5                   10                  15      


Val Met Pro Glu Ala Pro Leu Glu Ser Pro Pro Phe Pro Thr Lys Ser 
            20                  25                  30          


Pro Ala Phe Asp Leu Phe Asn Leu Val Leu Ser Tyr Lys Arg Leu Glu 
        35                  40                  45              


Ile Tyr Leu Glu Pro Leu Lys Asp Ala Gly Asp Gly Val Arg Tyr Leu 
    50                  55                  60                  


Leu Arg Trp Gln Met Pro Leu Cys Ser Leu Leu Thr Cys Leu Gly Leu 
65                  70                  75                  80  


Asn Val Leu Phe Leu Thr Leu Asn Glu Gly Ala Trp Tyr Ser Val Gly 
                85                  90                  95      


Ala Leu Met Ile Ser Val Pro Ala Leu Leu Gly Tyr Leu Gln Glu Val 
            100                 105                 110         


Cys Arg Ala Arg Leu Pro Asp Ser Glu Leu Met Arg Arg Lys Tyr His 
        115                 120                 125             


Ser Val Arg Gln Glu Asp Leu Gln Arg Gly Arg Leu Ser Arg Pro Glu 
    130                 135                 140                 


Ala Val Ala Glu Val Lys Ser Phe Leu Ile Gln Leu Glu Ala Phe Leu 
145                 150                 155                 160 


Ser Arg Leu Cys Cys Thr Cys Glu Ala Ala Tyr Arg Val Leu His Trp 
                165                 170                 175     


Glu Asn Pro Val Val Ser Ser Gln Phe Tyr Gly Ala Leu Leu Gly Thr 
            180                 185                 190         


Val Cys Met Leu Tyr Leu Leu Pro Leu Cys Trp Val Leu Thr Leu Leu 
        195                 200                 205             


Asn Ser Thr Leu Phe Leu Gly Asn Val Glu Phe Phe Arg Val Val Ser 
    210                 215                 220                 


Glu Tyr Arg Ala Ser Leu Gln Gln Arg Met Asn Pro Lys Gln Glu Glu 
225                 230                 235                 240 


His Ala Phe Glu Ser Pro Pro Pro Pro Asp Val Gly Gly Lys Asp Gly 
                245                 250                 255     


Leu Met Asp Ser Thr Pro Ala Leu Thr Pro Thr Glu Ser Leu Ser Ser 
            260                 265                 270         


Gln Asp Leu Thr Pro Gly Ser Val Glu Glu Ala Glu Glu Ala Glu Pro 
        275                 280                 285             


Asp Glu Glu Phe Lys Asp Ala Ile Glu Glu Thr His Leu Val Val Leu 
    290                 295                 300                 


Glu Asp Asp Glu Gly Ala Pro Cys Pro Ala Glu Asp Glu Leu Ala Leu 
305                 310                 315                 320 


Gln Asp Asn Gly Phe Leu Ser Lys Asn Glu Val Leu Arg Ser Lys Val 
                325                 330                 335     


Ser Arg Leu Thr Glu Arg Leu Arg Lys Arg Tyr Pro Thr Asn Asn Phe 
            340                 345                 350         


Gly Asn Cys Thr Gly Cys Ser Ala Thr Phe Ser Val Leu Lys Lys Arg 
        355                 360                 365             


Arg Ser Cys Ser Asn Cys Gly Asn Ser Phe Cys Ser Arg Cys Cys Ser 
    370                 375                 380                 


Phe Lys Val Pro Lys Ser Ser Met Gly Ala Thr Ala Pro Glu Ala Gln 
385                 390                 395                 400 


Arg Glu Thr Val Phe Val Cys Ala Ser Cys Asn Gln Thr Leu Ser Lys 
                405                 410                 415     


<210>  394
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  394

Met Gln Thr Ser Glu Arg Glu Gly Ser Gly Pro Glu Leu Ser Pro Ser 
1               5                   10                  15      


Val Met Pro Glu Ala Pro Leu Glu Ser Pro Pro Phe Pro Thr Lys Ser 
            20                  25                  30          


Pro Ala Phe Asp Leu Phe Asn Leu Val Leu Ser Tyr Lys Arg Leu Glu 
        35                  40                  45              


Ile Tyr Leu Glu Pro Leu Lys Asp Ala Gly Asp Gly Val Arg Tyr Leu 
    50                  55                  60                  


Leu Arg Trp Gln Met Pro Leu Cys Ser Leu Leu Thr Cys Leu Gly Leu 
65                  70                  75                  80  


Asn Val Leu Phe Leu Thr Leu Asn Glu Gly Ala Trp Tyr Ser Val Gly 
                85                  90                  95      


Ala Leu Met Ile Ser Val Pro Ala Leu Leu Gly Tyr Leu Gln Glu Val 
            100                 105                 110         


Cys Arg Ala Arg Leu Pro Asp Ser Glu Leu Met Arg Arg Lys Tyr His 
        115                 120                 125             


Ser Val Arg Gln Glu Asp Leu Gln Arg Gly Arg Leu Ser Arg Pro Glu 
    130                 135                 140                 


Ala Val Ala Glu Val Lys Ser Phe Leu Ile Gln Leu Glu Ala Phe Leu 
145                 150                 155                 160 


Ser Arg Leu Cys Cys Thr Cys Glu Ala Ala Tyr Arg Val Leu His Trp 
                165                 170                 175     


Glu Asn Pro Val Val Ser Ser Gln Phe Tyr Gly Ala Leu Leu Gly Thr 
            180                 185                 190         


Val Cys Met Leu Tyr Leu Leu Pro Leu Cys Trp Val Leu Thr Leu Leu 
        195                 200                 205             


Asn Ser Thr Leu Phe Leu Gly Asn Val Glu Phe Phe Arg Val Val Ser 
    210                 215                 220                 


Glu Tyr Arg Ala Ser Leu Gln Gln Arg Met Asn Pro Lys Gln Glu Glu 
225                 230                 235                 240 


His Ala Phe Glu Ser Pro Pro Pro Pro Asp Val Gly Gly Lys Asp Gly 
                245                 250                 255     


Leu Met Asp Ser Thr Pro Ala Leu Thr Pro Thr Glu Asp Leu Thr Pro 
            260                 265                 270         


Gly Ser Val Glu Glu Ala Glu Glu Ala Glu Pro Asp Glu Glu Phe Lys 
        275                 280                 285             


Asp Ala Ile Glu Glu Asp Asp Glu Gly Ala Pro Cys Pro Ala Glu Asp 
    290                 295                 300                 


Glu Leu Ala Leu Gln Asp Asn Gly Phe Leu Ser Lys Asn Glu Val Leu 
305                 310                 315                 320 


Arg Ser Lys Val Ser Arg Leu Thr Glu Arg Leu Arg Lys Arg Tyr Pro 
                325                 330                 335     


Thr Asn Asn Phe Gly Asn Cys Thr Gly Cys Ser Ala Thr Phe Ser Val 
            340                 345                 350         


Leu Lys Lys Arg Arg Ser Cys Ser Asn Cys Gly Asn Ser Phe Cys Ser 
        355                 360                 365             


Arg Cys Cys Ser Phe Lys Val Pro Lys Ser Ser Met Gly Ala Thr Ala 
    370                 375                 380                 


Pro Glu Ala Gln Arg Glu Thr Val Phe Val Cys Ala Ser Cys Asn Gln 
385                 390                 395                 400 


Thr Leu Ser Lys 
                


<210>  395
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  395

Met Asn Thr Arg Asn Arg Val Val Asn Ser Gly Leu Gly Ala Ser Pro 
1               5                   10                  15      


Ala Ser Arg Pro Thr Arg Asp Pro Gln Asp Pro Ser Gly Arg Gln Gly 
            20                  25                  30          


Glu Leu Ser Pro Val Glu Asp Gln Arg Glu Gly Leu Glu Ala Ala Pro 
        35                  40                  45              


Lys Gly Pro Ser Arg Glu Ser Val Val His Ala Gly Gln Arg Arg Thr 
    50                  55                  60                  


Ser Ala Tyr Thr Leu Ile Ala Pro Asn Ile Asn Arg Arg Asn Glu Ile 
65                  70                  75                  80  


Gln Arg Ile Ala Glu Gln Glu Leu Ala Asn Leu Glu Lys Trp Lys Glu 
                85                  90                  95      


Gln Asn Arg Ala Lys Pro Val His Leu Val Pro Arg Arg Leu Gly Gly 
            100                 105                 110         


Ser Gln Ser Glu Thr Glu Val Arg Gln Lys Gln Gln Leu Gln Leu Met 
        115                 120                 125             


Gln Ser Lys Tyr Lys Gln Lys Leu Lys Arg Glu Glu Ser Val Arg Ile 
    130                 135                 140                 


Lys Lys Glu Ala Glu Glu Ala Glu Leu Gln Lys Met Lys Ala Ile Gln 
145                 150                 155                 160 


Arg Glu Lys Ser Asn Lys Leu Glu Glu Lys Lys Arg Leu Gln Glu Asn 
                165                 170                 175     


Leu Arg Arg Glu Ala Phe Arg Glu His Gln Gln Tyr Lys Thr Ala Glu 
            180                 185                 190         


Phe Leu Ser Lys Leu Asn Thr Glu Ser Pro Asp Arg Ser Ala Cys Gln 
        195                 200                 205             


Ser Ala Val Cys Gly Pro Gln Ser Ser Thr Trp Lys Leu Pro Ile Leu 
    210                 215                 220                 


Pro Arg Asp His Ser Trp Ala Arg Ser Trp Ala Tyr Arg Asp Ser Leu 
225                 230                 235                 240 


Lys Ala Glu Glu Asn Arg Lys Leu Gln Lys Met Lys Asp Glu Gln His 
                245                 250                 255     


Gln Lys Ser Glu Leu Leu Glu Leu Lys Arg Gln Gln Gln Glu Gln Glu 
            260                 265                 270         


Arg Ala Lys Ile His Gln Thr Glu His Arg Arg Val Asn Asn Ala Phe 
        275                 280                 285             


Leu Asp Arg Leu Gln Gly Lys Ser Gln Pro Gly Gly Leu Glu Gln Ser 
    290                 295                 300                 


Gly Gly Cys Trp Asn Met Asn Ser Gly Asn Ser Trp Gly Ser Leu Leu 
305                 310                 315                 320 


Val Phe Ser Arg His Leu Arg Val Tyr Glu Lys Ile Leu Thr Pro Ile 
                325                 330                 335     


Trp Pro Ser Ser Thr Asp Leu Glu Lys Pro His Glu Met Leu Phe Leu 
            340                 345                 350         


Asn Val Ile Leu Phe Ser Leu Thr Val Phe Thr Leu Ile Ser Thr Ala 
        355                 360                 365             


His Thr Leu Asp Arg Ala Val Arg Ser Asp Trp Leu Leu Leu Val Leu 
    370                 375                 380                 


Ile Tyr Ala Cys Leu Glu Glu Leu Ile Pro Glu Leu Ile Phe Asn Leu 
385                 390                 395                 400 


Tyr Cys Gln Gly Asn Ala Thr Leu Phe Phe 
                405                 410 


<210>  396
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  396

Met Ser Met Pro Leu His Gln Ile Ser Ala Ile Pro Ser Gln Asp Ala 
1               5                   10                  15      


Ile Ser Ala Arg Val Tyr Arg Ser Lys Thr Lys Glu Lys Glu Arg Glu 
            20                  25                  30          


Glu Gln Asn Glu Lys Thr Leu Gly His Phe Met Ser His Ser Ser Asn 
        35                  40                  45              


Ile Ser Lys Ala Gly Ser Pro Pro Ser Ala Ser Ala Pro Ala Pro Val 
    50                  55                  60                  


Ser Ser Phe Ser Arg Thr Ser Ile Thr Pro Ser Ser Gln Asp Ile Cys 
65                  70                  75                  80  


Arg Ile Cys His Cys Glu Gly Asp Asp Glu Ser Pro Leu Ile Thr Pro 
                85                  90                  95      


Cys His Cys Thr Gly Ser Leu His Phe Val His Gln Ala Cys Leu Gln 
            100                 105                 110         


Gln Trp Ile Lys Ser Ser Asp Thr Arg Cys Cys Glu Leu Cys Lys Tyr 
        115                 120                 125             


Glu Phe Ile Met Glu Thr Lys Leu Lys Pro Leu Arg Lys Trp Glu Lys 
    130                 135                 140                 


Leu Gln Met Thr Ser Ser Glu Arg Arg Lys Ile Met Cys Ser Val Thr 
145                 150                 155                 160 


Phe His Val Ile Ala Ile Thr Cys Val Val Trp Ser Leu Tyr Val Leu 
                165                 170                 175     


Ile Asp Arg Thr Ala Glu Glu Ile Lys Gln Gly Gln Ala Thr Gly Ile 
            180                 185                 190         


Leu Glu Trp Pro Phe Trp Thr Lys Leu Val Val Val Ala Ile Gly Phe 
        195                 200                 205             


Thr Gly Gly Leu Leu Phe Met Tyr Val Gln Cys Lys Val Tyr Val Gln 
    210                 215                 220                 


Leu Trp Lys Arg Leu Lys Ala Tyr Asn Arg Val Ile Tyr Val Gln Asn 
225                 230                 235                 240 


Cys Pro Glu Thr Ser Lys Lys Asn Ile Phe Glu Lys Ser Pro Leu Thr 
                245                 250                 255     


Glu Pro Asn Phe Glu Asn Lys His Gly Tyr Gly Ile Cys His Ser Asp 
            260                 265                 270         


Thr Asn Ser Ser Cys Cys Thr Glu Pro Glu Asp Thr Gly Ala Glu Ile 
        275                 280                 285             


Ile His Val 
    290     


<210>  397
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  397

Met Ser Met Pro Leu His Gln Ile Ser Ala Ile Pro Ser Gln Asp Ala 
1               5                   10                  15      


Ile Ser Ala Arg Val Tyr Arg Ser Lys Thr Lys Glu Lys Glu Arg Glu 
            20                  25                  30          


Glu Gln Asn Glu Lys Thr Leu Gly His Phe Met Ser His Ser Ser Asn 
        35                  40                  45              


Ile Ser Lys Ala Gly Ser Pro Pro Ser Ala Ser Ala Pro Ala Pro Val 
    50                  55                  60                  


Ser Ser Phe Ser Arg Thr Ser Ile Thr Pro Ser Ser Gln Asp Ile Cys 
65                  70                  75                  80  


Arg Ile Cys His Cys Glu Gly Asp Asp Glu Ser Pro Leu Ile Thr Pro 
                85                  90                  95      


Cys His Cys Thr Gly Ser Leu His Phe Val His Gln Ala Cys Leu Gln 
            100                 105                 110         


Gln Trp Ile Lys Ser Ser Asp Thr Arg Cys Cys Glu Leu Cys Lys Tyr 
        115                 120                 125             


Glu Phe Ile Met Glu Thr Lys Leu Lys Pro Leu Arg Lys Trp Glu Lys 
    130                 135                 140                 


Leu Gln Met Thr Ser Ser Glu Arg Arg Lys Ile Met Cys Ser Val Thr 
145                 150                 155                 160 


Phe His Val Ile Ala Ile Thr Cys Val Val Trp Ser Leu Tyr Val Leu 
                165                 170                 175     


Ile Asp Arg Thr Ala Glu Glu Ile Lys Gln Gly Gln Ala Thr Gly Ile 
            180                 185                 190         


Leu Glu Trp Pro Phe Trp Thr Lys Leu Val Val Val Ala Ile Gly Phe 
        195                 200                 205             


Thr Gly Gly Leu Leu Phe Met Tyr Val Gln Cys Lys Val Tyr Val Gln 
    210                 215                 220                 


Leu Trp Lys Arg Leu Lys Ala Tyr Asn Arg Val Ile Tyr Val Gln Asn 
225                 230                 235                 240 


Cys Pro Glu Thr Ser Lys Lys Asn Ile Phe Glu Lys Ser Pro Leu Thr 
                245                 250                 255     


Glu Pro Asn Phe Glu Asn Lys His Gly Tyr Gly Ile Cys His Ser Asp 
            260                 265                 270         


Thr Asn Ser Ser Cys Cys Thr Glu Pro Glu Asp Thr Gly Ala Glu Ile 
        275                 280                 285             


Ile His Val 
    290     


<210>  398
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  398

Met Gly Ile Leu Ser Phe Leu Pro Val Leu Ala Thr Glu Ser Asp Trp 
1               5                   10                  15      


Ala Asp Cys Lys Ser Pro Gln Pro Trp Gly His Met Leu Leu Trp Thr 
            20                  25                  30          


Ala Val Leu Phe Leu Ala Pro Val Ala Gly Thr Pro Ala Pro Pro Lys 
        35                  40                  45              


Ala Val Leu Lys Leu Glu Pro Gln Trp Ile Asn Val Leu Gln Glu Asp 
    50                  55                  60                  


Ser Val Thr Leu Thr Cys Arg Gly Thr His Ser Pro Glu Ser Asp Ser 
65                  70                  75                  80  


Ile Gln Trp Phe His Asn Gly Asn Leu Ile Pro Thr His Thr Gln Pro 
                85                  90                  95      


Ser Tyr Arg Phe Lys Ala Asn Asn Asn Asp Ser Gly Glu Tyr Thr Cys 
            100                 105                 110         


Gln Thr Gly Gln Thr Ser Leu Ser Asp Pro Val His Leu Thr Val Leu 
        115                 120                 125             


Ser Glu Trp Leu Val Leu Gln Thr Pro His Leu Glu Phe Gln Glu Gly 
    130                 135                 140                 


Glu Thr Ile Val Leu Arg Cys His Ser Trp Lys Asp Lys Pro Leu Val 
145                 150                 155                 160 


Lys Val Thr Phe Phe Gln Asn Gly Lys Ser Lys Lys Phe Ser Arg Ser 
                165                 170                 175     


Asp Pro Asn Phe Ser Ile Pro Gln Ala Asn His Ser His Ser Gly Asp 
            180                 185                 190         


Tyr His Cys Thr Gly Asn Ile Gly Tyr Thr Leu Tyr Ser Ser Lys Pro 
        195                 200                 205             


Val Thr Ile Thr Val Gln Ala Pro Ser Ser Ser Pro Met Gly Ile Ile 
    210                 215                 220                 


Val Ala Val Val Thr Gly Ile Ala Val Ala Ala Ile Val Ala Ala Val 
225                 230                 235                 240 


Val Ala Leu Ile Tyr Cys Arg Lys Lys Arg Ile Ser Ala Asn Pro Thr 
                245                 250                 255     


Asn Pro Asp Glu Ala Asp Lys Val Gly Ala Glu Asn Thr Ile Thr Tyr 
            260                 265                 270         


Ser Leu Leu Met His Pro Asp Ala Leu Glu Glu Pro Asp Asp Gln Asn 
        275                 280                 285             


Arg Ile 
    290 


<210>  399
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  399

Met Gly Ile Leu Ser Phe Leu Pro Val Leu Ala Thr Glu Ser Asp Trp 
1               5                   10                  15      


Ala Asp Cys Lys Ser Pro Gln Pro Trp Gly His Met Leu Leu Trp Thr 
            20                  25                  30          


Ala Val Leu Phe Leu Ala Pro Val Ala Gly Thr Pro Ala Ala Pro Pro 
        35                  40                  45              


Lys Ala Val Leu Lys Leu Glu Pro Gln Trp Ile Asn Val Leu Gln Glu 
    50                  55                  60                  


Asp Ser Val Thr Leu Thr Cys Arg Gly Thr His Ser Pro Glu Ser Asp 
65                  70                  75                  80  


Ser Ile Gln Trp Phe His Asn Gly Asn Leu Ile Pro Thr His Thr Gln 
                85                  90                  95      


Pro Ser Tyr Arg Phe Lys Ala Asn Asn Asn Asp Ser Gly Glu Tyr Thr 
            100                 105                 110         


Cys Gln Thr Gly Gln Thr Ser Leu Ser Asp Pro Val His Leu Thr Val 
        115                 120                 125             


Leu Ser Glu Trp Leu Val Leu Gln Thr Pro His Leu Glu Phe Gln Glu 
    130                 135                 140                 


Gly Glu Thr Ile Val Leu Arg Cys His Ser Trp Lys Asp Lys Pro Leu 
145                 150                 155                 160 


Val Lys Val Thr Phe Phe Gln Asn Gly Lys Ser Lys Lys Phe Ser Arg 
                165                 170                 175     


Ser Asp Pro Asn Phe Ser Ile Pro Gln Ala Asn His Ser His Ser Gly 
            180                 185                 190         


Asp Tyr His Cys Thr Gly Asn Ile Gly Tyr Thr Leu Tyr Ser Ser Lys 
        195                 200                 205             


Pro Val Thr Ile Thr Val Gln Ala Pro Ser Ser Ser Pro Met Gly Ile 
    210                 215                 220                 


Ile Val Ala Val Val Thr Gly Ile Ala Val Ala Ala Ile Val Ala Ala 
225                 230                 235                 240 


Val Val Ala Leu Ile Tyr Cys Arg Lys Lys Arg Ile Ser Ala Asn Pro 
                245                 250                 255     


Thr Asn Pro Asp Glu Ala Asp Lys Val Gly Ala Glu Asn Thr Ile Thr 
            260                 265                 270         


Tyr Ser Leu Leu Met His Pro Asp Ala Leu Glu Glu Pro Asp Asp Gln 
        275                 280                 285             


Asn Arg Ile 
    290     


<210>  400
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  400

Met Gly Ile Leu Ser Phe Leu Pro Val Leu Ala Thr Glu Ser Asp Trp 
1               5                   10                  15      


Ala Asp Cys Lys Ser Pro Gln Pro Trp Gly His Met Leu Leu Trp Thr 
            20                  25                  30          


Ala Val Leu Phe Leu Ala Pro Val Ala Gly Thr Pro Ala Pro Pro Lys 
        35                  40                  45              


Ala Val Leu Lys Leu Glu Pro Gln Trp Ile Asn Val Leu Gln Glu Asp 
    50                  55                  60                  


Ser Val Thr Leu Thr Cys Arg Gly Thr His Ser Pro Glu Ser Asp Ser 
65                  70                  75                  80  


Ile Gln Trp Phe His Asn Gly Asn Leu Ile Pro Thr His Thr Gln Pro 
                85                  90                  95      


Ser Tyr Arg Phe Lys Ala Asn Asn Asn Asp Ser Gly Glu Tyr Thr Cys 
            100                 105                 110         


Gln Thr Gly Gln Thr Ser Leu Ser Asp Pro Val His Leu Thr Val Leu 
        115                 120                 125             


Ser Glu Trp Leu Val Leu Gln Thr Pro His Leu Glu Phe Gln Glu Gly 
    130                 135                 140                 


Glu Thr Ile Val Leu Arg Cys His Ser Trp Lys Asp Lys Pro Leu Val 
145                 150                 155                 160 


Lys Val Thr Phe Phe Gln Asn Gly Lys Ser Lys Lys Phe Ser Arg Ser 
                165                 170                 175     


Asp Pro Asn Phe Ser Ile Pro Gln Ala Asn His Ser His Ser Gly Asp 
            180                 185                 190         


Tyr His Cys Thr Gly Asn Ile Gly Tyr Thr Leu Tyr Ser Ser Lys Pro 
        195                 200                 205             


Val Thr Ile Thr Val Gln Ala Pro Ser Ser Ser Pro Met Gly Ile Ile 
    210                 215                 220                 


Val Ala Val Val Thr Gly Ile Ala Val Ala Ala Ile Val Ala Ala Val 
225                 230                 235                 240 


Val Ala Leu Ile Tyr Cys Arg Lys Lys Arg Ile Ser Ala Leu Pro Gly 
                245                 250                 255     


Tyr Pro Glu Cys Arg Glu Met Gly Glu Thr Leu Pro Glu Lys Pro Ala 
            260                 265                 270         


Asn Pro Thr Asn Pro Asp Glu Ala Asp Lys Val Gly Ala Glu Asn Thr 
        275                 280                 285             


Ile Thr Tyr Ser Leu Leu Met His Pro Asp Ala Leu Glu Glu Pro Asp 
    290                 295                 300                 


Asp Gln Asn Arg Ile 
305                 


<210>  401
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  401

Met Ala Gly Ala Ile Ile Glu Asn Met Ser Thr Lys Lys Leu Cys Ile 
1               5                   10                  15      


Val Gly Gly Ile Leu Leu Val Phe Gln Ile Ile Ala Phe Leu Val Gly 
            20                  25                  30          


Gly Leu Ile Gly Pro Thr Thr Ala Val Ser Tyr Met Ser Val Lys Cys 
        35                  40                  45              


Val Asp Ala Arg Lys Asn His His Lys Thr Lys Trp Phe Val Pro Trp 
    50                  55                  60                  


Gly Pro Asn His Cys Asp Lys Ile Arg Asp Ile Glu Glu Ala Ile Pro 
65                  70                  75                  80  


Arg Glu Ile Glu Ala Asn Asp Ile Val Phe Ser Val His Ile Pro Leu 
                85                  90                  95      


Pro His Met Glu Met Ser Pro Trp Phe Gln Phe Met Leu Phe Ile Leu 
            100                 105                 110         


Gln Leu Asp Ile Ala Phe Lys Leu Asn Asn Gln Ile Arg Glu Asn Ala 
        115                 120                 125             


Glu Val Ser Met Asp Val Ser Leu Ala Tyr Arg Asp Asp Ala Phe Ala 
    130                 135                 140                 


Glu Trp Thr Glu Met Ala His Glu Arg Val Pro Arg Lys Leu Lys Cys 
145                 150                 155                 160 


Thr Phe Thr Ser Pro Lys Thr Pro Glu His Glu Gly Arg Tyr Tyr Glu 
                165                 170                 175     


Cys Asp Val Leu Pro Phe Met Glu Ile Gly Ser Val Ala His Lys Phe 
            180                 185                 190         


Tyr Leu Leu Asn Ile Arg Leu Pro Val Asn Glu Lys Lys Lys Ile Asn 
        195                 200                 205             


Val Gly Ile Gly Glu Ile Lys Asp Ile Arg Leu Val Gly Ile His Gln 
    210                 215                 220                 


Asn Gly Gly Phe Thr Lys Val Trp Phe Ala Met Lys Thr Phe Leu Thr 
225                 230                 235                 240 


Pro Ser Ile Phe Ile Ile Met Val Trp Tyr Trp Arg Arg Ile Thr Met 
                245                 250                 255     


Met Ser Arg Pro Pro Val Leu Leu Glu Lys Val Ile Phe Ala Leu Gly 
            260                 265                 270         


Ile Ser Met Thr Phe Ile Asn Ile Pro Val Glu Trp Phe Ser Ile Gly 
        275                 280                 285             


Phe Asp Trp Thr Trp Met Leu Leu Phe Gly Asp Ile Arg Gln Gly Ile 
    290                 295                 300                 


Phe Tyr Ala Met Leu Leu Ser Phe Trp Ile Ile Phe Cys Gly Glu His 
305                 310                 315                 320 


Met Met Asp Gln His Glu Arg Asn His Ile Ala Gly Tyr Trp Lys Gln 
                325                 330                 335     


Val Gly Pro Ile Ala Val Gly Ser Phe Cys Leu Phe Ile Phe Asp Met 
            340                 345                 350         


Cys Glu Arg Gly Val Gln Leu Thr Asn Pro Phe Tyr Ser Ile Trp Thr 
        355                 360                 365             


Thr Asp Ile Gly Thr Glu Leu Ala Met Ala Phe Ile Ile Val Ala Gly 
    370                 375                 380                 


Ile Cys Leu Cys Leu Tyr Phe Leu Phe Leu Cys Phe Met Val Phe Gln 
385                 390                 395                 400 


Val Phe Arg Asn Ile Ser Gly Lys Gln Ser Ser Leu Pro Ala Met Ser 
                405                 410                 415     


Lys Val Arg Arg Leu His Tyr Glu Gly Leu Ile Phe Arg Phe Lys Phe 
            420                 425                 430         


Leu Met Leu Ile Thr Leu Ala Cys Ala Ala Met Thr Val Ile Phe Phe 
        435                 440                 445             


Ile Val Ser Gln Val Thr Glu Gly His Trp Lys Trp Gly Gly Val Thr 
    450                 455                 460                 


Val Gln Val Asn Ser Ala Phe Phe Thr Gly Ile Tyr Gly Met Trp Asn 
465                 470                 475                 480 


Leu Tyr Val Phe Ala Leu Met Phe Leu Tyr Ala Pro Ser His Lys Asn 
                485                 490                 495     


Tyr Gly Glu Asp Gln Ser Asn Gly Met Gln Leu Pro Cys Lys Ser Arg 
            500                 505                 510         


Glu Asp Cys Ala Leu Phe Val Ser Glu Leu Tyr Gln Glu Leu Phe Ser 
        515                 520                 525             


Ala Ser Lys Tyr Ser Phe Ile Asn Asp Asn Ala Ala Ser Gly Ile 
    530                 535                 540             


<210>  402
<211>  532
<212>  PRT
<213>  Homo sapiens

<400>  402

Met Gly Lys Lys Val Ala Ile Ile Gly Ala Gly Val Ser Gly Leu Ala 
1               5                   10                  15      


Ser Ile Arg Ser Cys Leu Glu Glu Gly Leu Glu Pro Thr Cys Phe Glu 
            20                  25                  30          


Lys Ser Asn Asp Ile Gly Gly Leu Trp Lys Phe Ser Asp His Ala Glu 
        35                  40                  45              


Glu Gly Arg Ala Ser Ile Tyr Lys Ser Val Phe Ser Asn Ser Ser Lys 
    50                  55                  60                  


Glu Met Met Cys Phe Pro Asp Phe Pro Phe Pro Asp Asp Phe Pro Asn 
65                  70                  75                  80  


Phe Met His Asn Ser Lys Ile Gln Glu Tyr Ile Ile Ala Phe Ala Lys 
                85                  90                  95      


Glu Lys Asn Leu Leu Lys Tyr Ile Gln Phe Lys Thr Phe Val Ser Ser 
            100                 105                 110         


Val Asn Lys His Pro Asp Phe Ala Thr Thr Gly Gln Trp Asp Val Thr 
        115                 120                 125             


Thr Glu Arg Asp Gly Lys Lys Glu Ser Ala Val Phe Asp Ala Val Met 
    130                 135                 140                 


Val Cys Ser Gly His His Val Tyr Pro Asn Leu Pro Lys Glu Ser Phe 
145                 150                 155                 160 


Pro Gly Leu Asn His Phe Lys Gly Lys Cys Phe His Ser Arg Asp Tyr 
                165                 170                 175     


Lys Glu Pro Gly Val Phe Asn Gly Lys Arg Val Leu Val Val Gly Leu 
            180                 185                 190         


Gly Asn Ser Gly Cys Asp Ile Ala Thr Glu Leu Ser Arg Thr Ala Glu 
        195                 200                 205             


Gln Val Met Ile Ser Ser Arg Ser Gly Ser Trp Val Met Ser Arg Val 
    210                 215                 220                 


Trp Asp Asn Gly Tyr Pro Trp Asp Met Leu Leu Val Thr Arg Phe Gly 
225                 230                 235                 240 


Thr Phe Leu Lys Asn Asn Leu Pro Thr Ala Ile Ser Asp Trp Leu Tyr 
                245                 250                 255     


Val Lys Gln Met Asn Ala Arg Phe Lys His Glu Asn Tyr Gly Leu Met 
            260                 265                 270         


Pro Leu Asn Gly Val Leu Arg Lys Glu Pro Val Phe Asn Asp Glu Leu 
        275                 280                 285             


Pro Ala Ser Ile Leu Cys Gly Ile Val Ser Val Lys Pro Asn Val Lys 
    290                 295                 300                 


Glu Phe Thr Glu Thr Ser Ala Ile Phe Glu Asp Gly Thr Ile Phe Glu 
305                 310                 315                 320 


Gly Ile Asp Cys Val Ile Phe Ala Thr Gly Tyr Ser Phe Ala Tyr Pro 
                325                 330                 335     


Phe Leu Asp Glu Ser Ile Ile Lys Ser Arg Asn Asn Glu Ile Ile Leu 
            340                 345                 350         


Phe Lys Gly Val Phe Pro Pro Leu Leu Glu Lys Ser Thr Ile Ala Val 
        355                 360                 365             


Ile Gly Phe Val Gln Ser Leu Gly Ala Ala Ile Pro Thr Val Asp Leu 
    370                 375                 380                 


Gln Ser Arg Trp Ala Ala Gln Val Ile Lys Gly Thr Cys Thr Leu Pro 
385                 390                 395                 400 


Ser Met Glu Asp Met Met Asn Asp Ile Asn Glu Lys Met Glu Lys Lys 
                405                 410                 415     


Arg Lys Trp Phe Gly Lys Ser Glu Thr Ile Gln Thr Asp Tyr Ile Val 
            420                 425                 430         


Tyr Met Asp Glu Leu Ser Ser Phe Ile Gly Ala Lys Pro Asn Ile Pro 
        435                 440                 445             


Trp Leu Phe Leu Thr Asp Pro Lys Leu Ala Met Glu Val Tyr Phe Gly 
    450                 455                 460                 


Pro Cys Ser Pro Tyr Gln Phe Arg Leu Val Gly Pro Gly Gln Trp Pro 
465                 470                 475                 480 


Gly Ala Arg Asn Ala Ile Leu Thr Gln Trp Asp Arg Ser Leu Lys Pro 
                485                 490                 495     


Met Gln Thr Arg Val Val Gly Arg Leu Gln Lys Pro Cys Phe Phe Phe 
            500                 505                 510         


His Trp Leu Lys Leu Phe Ala Ile Pro Ile Leu Leu Ile Ala Val Phe 
        515                 520                 525             


Leu Val Leu Thr 
    530         


<210>  403
<211>  409
<212>  PRT
<213>  Homo sapiens

<400>  403

Met Ser Ser Leu Arg Ala Arg Leu Pro Ala Thr Arg Arg Arg Val Ala 
1               5                   10                  15      


Gln Pro Phe Ala Arg Pro Ala Ser Pro Ser Leu Val Pro Arg Ser Gly 
            20                  25                  30          


Ser Ala Met Glu Ser Asn Lys Asp Glu Ala Glu Arg Cys Ile Ser Ile 
        35                  40                  45              


Ala Leu Lys Ala Ile Gln Ser Asn Gln Pro Asp Arg Ala Leu Arg Phe 
    50                  55                  60                  


Leu Glu Lys Ala Gln Arg Leu Tyr Pro Thr Pro Arg Val Arg Ala Leu 
65                  70                  75                  80  


Ile Glu Ser Leu Asn Gln Lys Pro Gln Thr Ala Gly Asp Gln Pro Pro 
                85                  90                  95      


Pro Thr Asp Thr Thr His Ala Thr His Arg Lys Ala Gly Gly Thr Asp 
            100                 105                 110         


Ala Pro Ser Ala Asn Gly Glu Ala Gly Gly Glu Ser Thr Lys Gly Tyr 
        115                 120                 125             


Thr Ala Glu Gln Val Ala Ala Val Lys Arg Val Lys Gln Cys Lys Asp 
    130                 135                 140                 


Tyr Tyr Glu Ile Leu Gly Val Ser Arg Gly Ala Ser Asp Glu Asp Leu 
145                 150                 155                 160 


Lys Lys Ala Tyr Arg Arg Leu Ala Leu Lys Phe His Pro Asp Lys Asn 
                165                 170                 175     


His Ala Pro Gly Ala Thr Glu Ala Phe Lys Ala Ile Gly Thr Ala Tyr 
            180                 185                 190         


Ala Val Leu Ser Asn Pro Glu Lys Arg Lys Gln Tyr Asp Gln Phe Gly 
        195                 200                 205             


Asp Asp Lys Ser Gln Ala Ala Arg His Gly His Gly His Gly Asp Phe 
    210                 215                 220                 


His Arg Gly Phe Glu Ala Asp Ile Ser Pro Glu Asp Leu Phe Asn Met 
225                 230                 235                 240 


Phe Phe Gly Gly Gly Phe Pro Ser Ser Asn Val His Val Tyr Ser Asn 
                245                 250                 255     


Gly Arg Met Arg Tyr Thr Tyr Gln Gln Arg Gln Asp Arg Arg Asp Asn 
            260                 265                 270         


Gln Gly Asp Gly Gly Leu Gly Val Phe Val Gln Leu Met Pro Ile Leu 
        275                 280                 285             


Ile Leu Ile Leu Val Ser Ala Leu Ser Gln Leu Met Val Ser Ser Pro 
    290                 295                 300                 


Pro Tyr Ser Leu Ser Pro Arg Pro Ser Val Gly His Ile His Arg Arg 
305                 310                 315                 320 


Val Thr Asp His Leu Gly Val Val Tyr Tyr Val Gly Asp Thr Phe Ser 
                325                 330                 335     


Glu Glu Tyr Thr Gly Ser Ser Leu Lys Thr Val Glu Arg Asn Val Glu 
            340                 345                 350         


Asp Asp Tyr Ile Ala Asn Leu Arg Asn Asn Cys Trp Lys Glu Lys Gln 
        355                 360                 365             


Gln Lys Glu Gly Leu Leu Tyr Arg Ala Arg Tyr Phe Gly Asp Thr Asp 
    370                 375                 380                 


Met Tyr His Arg Ala Gln Lys Met Gly Thr Pro Ser Cys Ser Arg Leu 
385                 390                 395                 400 


Ser Glu Val Gln Ala Ser Leu His Gly 
                405                 


<210>  404
<211>  778
<212>  PRT
<213>  Homo sapiens

<400>  404

Met Leu Asp Ser Cys Lys Leu Lys Ser Ala Cys Asn Leu Pro Phe Ile 
1               5                   10                  15      


Cys Asn Lys Lys Ile Ile Asn Thr Ala Gly Thr Ser Asn Ala Glu Val 
            20                  25                  30          


Pro Leu Ala Asp Pro Gly Met Tyr Gln Leu Asp Ile Thr Leu Arg Arg 
        35                  40                  45              


Gly Gln Ser Leu Ala Ala Arg Asp Arg Gly Gly Thr Ser Asp Pro Tyr 
    50                  55                  60                  


Val Lys Phe Lys Ile Gly Gly Lys Glu Val Phe Arg Ser Lys Ile Ile 
65                  70                  75                  80  


His Lys Asn Leu Asn Pro Val Trp Glu Glu Lys Ala Cys Ile Leu Val 
                85                  90                  95      


Asp His Leu Arg Glu Pro Leu Tyr Ile Lys Val Phe Asp Tyr Asp Phe 
            100                 105                 110         


Gly Leu Gln Asp Asp Phe Met Gly Ser Ala Phe Leu Asp Leu Thr Gln 
        115                 120                 125             


Leu Glu Leu Asn Arg Pro Thr Asp Val Thr Leu Thr Leu Lys Asp Pro 
    130                 135                 140                 


His Tyr Pro Asp His Asp Leu Gly Ile Ile Leu Leu Ser Val Ile Leu 
145                 150                 155                 160 


Thr Pro Lys Glu Gly Glu Ser Arg Asp Val Thr Met Leu Met Arg Lys 
                165                 170                 175     


Ser Trp Lys Arg Ser Ser Lys Glu Leu Ser Glu Asn Glu Val Val Gly 
            180                 185                 190         


Ser Tyr Phe Ser Val Lys Ser Leu Phe Trp Arg Thr Cys Gly Arg Pro 
        195                 200                 205             


Ala Leu Pro Val Leu Gly Phe Cys Arg Ala Glu Leu Gln Asn Pro Tyr 
    210                 215                 220                 


Cys Lys Asn Val Gln Phe Gln Thr Gln Ser Leu Arg Leu Ser Asp Leu 
225                 230                 235                 240 


His Arg Lys Ser His Leu Trp Arg Gly Ile Val Ser Ile Thr Leu Ile 
                245                 250                 255     


Glu Gly Arg Asp Leu Lys Ala Met Asp Ser Asn Gly Leu Ser Asp Pro 
            260                 265                 270         


Tyr Val Lys Phe Arg Leu Gly His Gln Lys Tyr Lys Ser Lys Ile Met 
        275                 280                 285             


Pro Lys Thr Leu Asn Pro Gln Trp Arg Glu Gln Phe Asp Phe His Leu 
    290                 295                 300                 


Tyr Glu Glu Arg Gly Gly Val Ile Asp Ile Thr Ala Trp Asp Lys Asp 
305                 310                 315                 320 


Ala Gly Lys Arg Asp Asp Phe Ile Gly Arg Cys Gln Val Asp Leu Ser 
                325                 330                 335     


Ala Leu Ser Arg Glu Gln Thr His Lys Leu Glu Leu Gln Leu Glu Glu 
            340                 345                 350         


Gly Glu Gly His Leu Val Leu Leu Val Thr Leu Thr Ala Ser Ala Thr 
        355                 360                 365             


Val Ser Ile Ser Asp Leu Ser Val Asn Ser Leu Glu Asp Gln Lys Glu 
    370                 375                 380                 


Arg Glu Glu Ile Leu Lys Arg Tyr Ser Pro Leu Arg Ile Phe His Asn 
385                 390                 395                 400 


Leu Lys Asp Val Gly Phe Leu Gln Val Lys Val Ile Arg Ala Glu Gly 
                405                 410                 415     


Leu Met Ala Ala Asp Val Thr Gly Lys Ser Asp Pro Phe Cys Val Val 
            420                 425                 430         


Glu Leu Asn Asn Asp Arg Leu Leu Thr His Thr Val Tyr Lys Asn Leu 
        435                 440                 445             


Asn Pro Glu Trp Asn Lys Val Phe Thr Phe Asn Ile Lys Asp Ile His 
    450                 455                 460                 


Ser Val Leu Glu Val Thr Val Tyr Asp Glu Asp Arg Asp Arg Ser Ala 
465                 470                 475                 480 


Asp Phe Leu Gly Lys Val Ala Ile Pro Leu Leu Ser Ile Gln Asn Gly 
                485                 490                 495     


Glu Gln Lys Ala Tyr Val Leu Lys Asn Lys Gln Leu Thr Gly Pro Thr 
            500                 505                 510         


Lys Gly Val Ile Tyr Leu Glu Ile Asp Val Ile Phe Asn Ala Val Lys 
        515                 520                 525             


Ala Ser Leu Arg Thr Leu Ile Pro Lys Glu Gln Lys Tyr Ile Glu Glu 
    530                 535                 540                 


Glu Asn Arg Leu Ser Lys Gln Leu Leu Leu Arg Asn Phe Ile Arg Met 
545                 550                 555                 560 


Lys Arg Cys Val Met Val Leu Val Asn Ala Ala Tyr Tyr Val Asn Ser 
                565                 570                 575     


Cys Phe Asp Trp Asp Ser Pro Pro Arg Ser Leu Ala Ala Phe Val Leu 
            580                 585                 590         


Phe Leu Phe Val Val Trp Asn Phe Glu Leu Tyr Met Ile Pro Leu Val 
        595                 600                 605             


Leu Leu Leu Leu Leu Thr Trp Asn Tyr Phe Leu Ile Ile Ser Gly Lys 
    610                 615                 620                 


Asp Asn Arg Gln Arg Asp Thr Val Val Glu Asp Met Leu Glu Asp Glu 
625                 630                 635                 640 


Glu Glu Glu Asp Asp Lys Asp Asp Lys Asp Ser Glu Lys Lys Gly Phe 
                645                 650                 655     


Ile Asn Lys Ile Tyr Ala Ile Gln Glu Val Cys Val Ser Val Gln Asn 
            660                 665                 670         


Ile Leu Asp Glu Val Ala Ser Phe Gly Glu Arg Ile Lys Asn Thr Phe 
        675                 680                 685             


Asn Trp Thr Val Pro Phe Leu Ser Trp Leu Ala Ile Val Ala Leu Cys 
    690                 695                 700                 


Val Phe Thr Ala Ile Leu Tyr Cys Ile Pro Leu Arg Tyr Ile Val Leu 
705                 710                 715                 720 


Val Trp Gly Ile Asn Lys Phe Thr Lys Lys Leu Arg Ser Pro Tyr Ala 
                725                 730                 735     


Ile Asp Asn Asn Glu Leu Leu Asp Phe Leu Ser Arg Val Pro Ser Asp 
            740                 745                 750         


Val Gln Val Val Gln Tyr Gln Glu Leu Lys Pro Asp Pro Ser His Ser 
        755                 760                 765             


Pro Tyr Lys Arg Lys Lys Asn Asn Leu Gly 
    770                 775             


<210>  405
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  405

Met Ser Gly Glu Asn Asn Ser Ser Val Thr Glu Phe Ile Leu Ala Gly 
1               5                   10                  15      


Leu Ser Glu Gln Pro Glu Leu Gln Leu Pro Leu Phe Leu Leu Phe Leu 
            20                  25                  30          


Gly Ile Tyr Val Val Thr Val Val Gly Asn Leu Gly Met Thr Thr Leu 
        35                  40                  45              


Ile Trp Leu Ser Ser His Leu His Thr Pro Met Tyr Tyr Phe Leu Ser 
    50                  55                  60                  


Ser Leu Ser Phe Ile Asp Phe Cys His Ser Thr Val Ile Thr Pro Lys 
65                  70                  75                  80  


Met Leu Val Asn Phe Val Thr Glu Lys Asn Ile Ile Ser Tyr Pro Glu 
                85                  90                  95      


Cys Met Thr Gln Leu Tyr Phe Phe Leu Val Phe Ala Ile Ala Glu Cys 
            100                 105                 110         


His Met Leu Ala Ala Met Ala Tyr Asp Arg Tyr Met Ala Ile Cys Ser 
        115                 120                 125             


Pro Leu Leu Tyr Ser Val Ile Ile Ser Asn Lys Ala Cys Phe Ser Leu 
    130                 135                 140                 


Ile Leu Gly Val Tyr Ile Ile Gly Leu Val Cys Ala Ser Val His Thr 
145                 150                 155                 160 


Gly Cys Met Phe Arg Val Gln Phe Cys Lys Phe Asp Leu Ile Asn His 
                165                 170                 175     


Tyr Phe Cys Asp Leu Leu Pro Leu Leu Lys Leu Ser Cys Ser Ser Ile 
            180                 185                 190         


Tyr Val Asn Lys Leu Leu Ile Leu Cys Val Gly Ala Phe Asn Ile Leu 
        195                 200                 205             


Val Pro Ser Leu Thr Ile Leu Cys Ser Tyr Ile Phe Ile Ile Ala Ser 
    210                 215                 220                 


Ile Leu His Ile Arg Ser Thr Glu Gly Arg Ser Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Ser Ser His Met Leu Ala Val Val Ile Phe Phe Gly Ser Ala Ala 
                245                 250                 255     


Phe Met Tyr Leu Gln Pro Ser Ser Ile Ser Ser Met Asp Gln Gly Lys 
            260                 265                 270         


Val Ser Ser Val Phe Tyr Thr Ile Ile Val Pro Met Leu Asn Pro Leu 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Asp Val His Val Ser Leu Lys Lys Met 
    290                 295                 300                 


Leu Gln Arg Arg Thr Leu Leu 
305                 310     


<210>  406
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  406

Met Thr Met Glu Asn Tyr Ser Met Ala Ala Gln Phe Val Leu Asp Gly 
1               5                   10                  15      


Leu Thr Gln Gln Ala Glu Leu Gln Leu Pro Leu Phe Leu Leu Phe Leu 
            20                  25                  30          


Gly Ile Tyr Val Val Thr Val Val Gly Asn Leu Gly Met Ile Leu Leu 
        35                  40                  45              


Ile Ala Val Ser Pro Leu Leu His Thr Pro Met Tyr Tyr Phe Leu Ser 
    50                  55                  60                  


Ser Leu Ser Phe Val Asp Phe Cys Tyr Ser Ser Val Ile Thr Pro Lys 
65                  70                  75                  80  


Met Leu Val Asn Phe Leu Gly Lys Lys Asn Thr Ile Leu Tyr Ser Glu 
                85                  90                  95      


Cys Met Val Gln Leu Phe Phe Phe Val Val Phe Val Val Ala Glu Gly 
            100                 105                 110         


Tyr Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser 
        115                 120                 125             


Pro Leu Leu Tyr Asn Ala Ile Met Ser Ser Trp Val Cys Ser Leu Leu 
    130                 135                 140                 


Val Leu Ala Ala Phe Phe Leu Gly Phe Leu Ser Ala Leu Thr His Thr 
145                 150                 155                 160 


Ser Ala Met Met Lys Leu Ser Phe Cys Lys Ser His Ile Ile Asn His 
                165                 170                 175     


Tyr Phe Cys Asp Val Leu Pro Leu Leu Asn Leu Ser Cys Ser Asn Thr 
            180                 185                 190         


His Leu Asn Glu Leu Leu Leu Phe Ile Ile Ala Gly Phe Asn Thr Leu 
        195                 200                 205             


Val Pro Thr Leu Ala Val Ala Val Ser Tyr Ala Phe Ile Leu Tyr Ser 
    210                 215                 220                 


Ile Leu His Ile Arg Ser Ser Glu Gly Arg Ser Lys Ala Phe Gly Thr 
225                 230                 235                 240 


Cys Ser Ser His Leu Met Ala Val Val Ile Phe Phe Gly Ser Ile Thr 
                245                 250                 255     


Phe Met Tyr Phe Lys Pro Pro Ser Ser Asn Ser Leu Asp Gln Glu Lys 
            260                 265                 270         


Val Ser Ser Val Phe Tyr Thr Thr Val Ile Pro Met Leu Asn Pro Leu 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Lys Ala Leu Arg Lys Val 
    290                 295                 300                 


Leu Val Gly Lys 
305             


<210>  407
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  407

Met Ala Thr Ser Asn His Ser Ser Gly Ala Glu Phe Ile Leu Ala Gly 
1               5                   10                  15      


Leu Thr Gln Arg Pro Glu Leu Gln Leu Pro Leu Phe Leu Leu Phe Leu 
            20                  25                  30          


Gly Ile Tyr Val Val Thr Val Val Gly Asn Leu Gly Met Ile Phe Leu 
        35                  40                  45              


Ile Ala Leu Ser Ser Gln Leu Tyr Pro Pro Val Tyr Tyr Phe Leu Ser 
    50                  55                  60                  


His Leu Ser Phe Ile Asp Leu Cys Tyr Ser Ser Val Ile Thr Pro Lys 
65                  70                  75                  80  


Met Leu Val Asn Phe Val Pro Glu Glu Asn Ile Ile Ser Phe Leu Glu 
                85                  90                  95      


Cys Ile Thr Gln Leu Tyr Phe Phe Leu Ile Phe Val Ile Ala Glu Gly 
            100                 105                 110         


Tyr Leu Leu Thr Ala Met Glu Tyr Asp Arg Tyr Val Ala Ile Cys Arg 
        115                 120                 125             


Pro Leu Leu Tyr Asn Ile Val Met Ser His Arg Val Cys Ser Ile Met 
    130                 135                 140                 


Met Ala Val Val Tyr Ser Leu Gly Phe Leu Trp Ala Thr Val His Thr 
145                 150                 155                 160 


Thr Arg Met Ser Val Leu Ser Phe Cys Arg Ser His Thr Val Ser His 
                165                 170                 175     


Tyr Phe Cys Asp Ile Leu Pro Leu Leu Thr Leu Ser Cys Ser Ser Thr 
            180                 185                 190         


His Ile Asn Glu Ile Leu Leu Phe Ile Ile Gly Gly Val Asn Thr Leu 
        195                 200                 205             


Ala Thr Thr Leu Ala Val Leu Ile Ser Tyr Ala Phe Ile Phe Ser Ser 
    210                 215                 220                 


Ile Leu Gly Ile His Ser Thr Glu Gly Gln Ser Lys Ala Phe Gly Thr 
225                 230                 235                 240 


Cys Ser Ser His Leu Leu Ala Val Gly Ile Phe Phe Gly Ser Ile Thr 
                245                 250                 255     


Phe Met Tyr Phe Lys Pro Pro Ser Ser Thr Thr Met Glu Lys Glu Lys 
            260                 265                 270         


Val Ser Ser Val Phe Tyr Ile Thr Ile Ile Pro Met Leu Asn Pro Leu 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asn Ala Leu Lys Lys Met 
    290                 295                 300                 


Thr Arg Gly Arg Gln Ser Ser 
305                 310     


<210>  408
<211>  2188
<212>  PRT
<213>  Homo sapiens

<400>  408

Met Ala Glu Ser Ala Ser Pro Pro Ser Ser Ser Ala Ala Ala Pro Ala 
1               5                   10                  15      


Ala Glu Pro Gly Val Thr Thr Glu Gln Pro Gly Pro Arg Ser Pro Pro 
            20                  25                  30          


Ser Ser Pro Pro Gly Leu Glu Glu Pro Leu Asp Gly Ala Asp Pro His 
        35                  40                  45              


Val Pro His Pro Asp Leu Ala Pro Ile Ala Phe Phe Cys Leu Arg Gln 
    50                  55                  60                  


Thr Thr Ser Pro Arg Asn Trp Cys Ile Lys Met Val Cys Asn Pro Trp 
65                  70                  75                  80  


Phe Glu Cys Val Ser Met Leu Val Ile Leu Leu Asn Cys Val Thr Leu 
                85                  90                  95      


Gly Met Tyr Gln Pro Cys Asp Asp Met Asp Cys Leu Ser Asp Arg Cys 
            100                 105                 110         


Lys Ile Leu Gln Val Phe Asp Asp Phe Ile Phe Ile Phe Phe Ala Met 
        115                 120                 125             


Glu Met Val Leu Lys Met Val Ala Leu Gly Ile Phe Gly Lys Lys Cys 
    130                 135                 140                 


Tyr Leu Gly Asp Thr Trp Asn Arg Leu Asp Phe Phe Ile Val Met Ala 
145                 150                 155                 160 


Gly Met Val Glu Tyr Ser Leu Asp Leu Gln Asn Ile Asn Leu Ser Ala 
                165                 170                 175     


Ile Arg Thr Val Arg Val Leu Arg Pro Leu Lys Ala Ile Asn Arg Val 
            180                 185                 190         


Pro Ser Met Arg Ile Leu Val Asn Leu Leu Leu Asp Thr Leu Pro Met 
        195                 200                 205             


Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile Phe Gly 
    210                 215                 220                 


Ile Ile Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg Cys Phe 
225                 230                 235                 240 


Leu Glu Glu Asn Phe Thr Ile Gln Gly Asp Val Ala Leu Pro Pro Tyr 
                245                 250                 255     


Tyr Gln Pro Glu Glu Asp Asp Glu Met Pro Phe Ile Cys Ser Leu Ser 
            260                 265                 270         


Gly Asp Asn Gly Ile Met Gly Cys His Glu Ile Pro Pro Leu Lys Glu 
        275                 280                 285             


Gln Gly Arg Glu Cys Cys Leu Ser Lys Asp Asp Val Tyr Asp Phe Gly 
    290                 295                 300                 


Ala Gly Arg Gln Asp Leu Asn Ala Ser Gly Leu Cys Val Asn Trp Asn 
305                 310                 315                 320 


Arg Tyr Tyr Asn Val Cys Arg Thr Gly Ser Ala Asn Pro His Lys Gly 
                325                 330                 335     


Ala Ile Asn Phe Asp Asn Ile Gly Tyr Ala Trp Ile Val Ile Phe Gln 
            340                 345                 350         


Val Ile Thr Leu Glu Gly Trp Val Glu Ile Met Tyr Tyr Val Met Asp 
        355                 360                 365             


Ala His Ser Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val 
    370                 375                 380                 


Gly Ser Phe Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Thr Gln 
385                 390                 395                 400 


Phe Ser Glu Thr Lys Gln Arg Glu His Arg Leu Met Leu Glu Gln Arg 
                405                 410                 415     


Gln Arg Tyr Leu Ser Ser Ser Thr Val Ala Ser Tyr Ala Glu Pro Gly 
            420                 425                 430         


Asp Cys Tyr Glu Glu Ile Phe Gln Tyr Val Cys His Ile Leu Arg Lys 
        435                 440                 445             


Ala Lys Arg Arg Ala Leu Gly Leu Tyr Gln Ala Leu Gln Ser Arg Arg 
    450                 455                 460                 


Gln Ala Leu Gly Pro Glu Ala Pro Ala Pro Ala Lys Pro Gly Pro His 
465                 470                 475                 480 


Ala Lys Glu Pro Arg His Tyr Gln Leu Cys Pro Gln His Ser Pro Leu 
                485                 490                 495     


Asp Ala Thr Pro His Thr Leu Val Gln Pro Ile Pro Ala Thr Leu Ala 
            500                 505                 510         


Ser Asp Pro Ala Ser Cys Pro Cys Cys Gln His Glu Asp Gly Arg Arg 
        515                 520                 525             


Pro Ser Gly Leu Gly Ser Thr Asp Ser Gly Gln Glu Gly Ser Gly Ser 
    530                 535                 540                 


Gly Ser Ser Ala Gly Gly Glu Asp Glu Ala Asp Gly Asp Gly Ala Arg 
545                 550                 555                 560 


Ser Ser Glu Asp Gly Ala Ser Ser Glu Leu Gly Lys Glu Glu Glu Glu 
                565                 570                 575     


Glu Glu Gln Ala Asp Gly Ala Val Trp Leu Cys Gly Asp Val Trp Arg 
            580                 585                 590         


Glu Thr Arg Ala Lys Leu Arg Gly Ile Val Asp Ser Lys Tyr Phe Asn 
        595                 600                 605             


Arg Gly Ile Met Met Ala Ile Leu Val Asn Thr Val Ser Met Gly Ile 
    610                 615                 620                 


Glu His His Glu Gln Pro Glu Glu Leu Thr Asn Ile Leu Glu Ile Cys 
625                 630                 635                 640 


Asn Val Val Phe Thr Ser Met Phe Ala Leu Glu Met Ile Leu Lys Leu 
                645                 650                 655     


Ala Ala Phe Gly Leu Phe Asp Tyr Leu Arg Asn Pro Tyr Asn Ile Phe 
            660                 665                 670         


Asp Ser Ile Ile Val Ile Ile Ser Ile Trp Glu Ile Val Gly Gln Ala 
        675                 680                 685             


Asp Gly Gly Leu Ser Val Leu Arg Thr Phe Arg Leu Leu Arg Val Leu 
    690                 695                 700                 


Lys Leu Val Arg Phe Met Pro Ala Leu Arg Arg Gln Leu Val Val Leu 
705                 710                 715                 720 


Met Lys Thr Met Asp Asn Val Ala Thr Phe Cys Met Leu Leu Met Leu 
                725                 730                 735     


Phe Ile Phe Ile Phe Ser Ile Leu Gly Met His Ile Phe Gly Cys Lys 
            740                 745                 750         


Phe Ser Leu Arg Thr Asp Thr Gly Asp Thr Val Pro Asp Arg Lys Asn 
        755                 760                 765             


Phe Asp Ser Leu Leu Trp Ala Ile Val Thr Val Phe Gln Ile Leu Thr 
    770                 775                 780                 


Gln Glu Asp Trp Asn Val Val Leu Tyr Asn Gly Met Ala Ser Thr Ser 
785                 790                 795                 800 


Pro Trp Ala Ser Leu Tyr Phe Val Ala Leu Met Thr Phe Gly Asn Tyr 
                805                 810                 815     


Val Leu Phe Asn Leu Leu Val Ala Ile Leu Val Glu Gly Phe Gln Ala 
            820                 825                 830         


Glu Gly Asp Ala Asn Arg Ser Tyr Ser Asp Glu Asp Gln Ser Ser Ser 
        835                 840                 845             


Asn Ile Glu Glu Phe Asp Lys Leu Gln Glu Gly Leu Asp Ser Ser Gly 
    850                 855                 860                 


Asp Pro Lys Leu Cys Pro Ile Pro Met Thr Pro Asn Gly His Leu Asp 
865                 870                 875                 880 


Pro Ser Leu Pro Leu Gly Gly His Leu Gly Pro Ala Gly Ala Ala Gly 
                885                 890                 895     


Pro Ala Pro Arg Leu Ser Leu Gln Pro Asp Pro Met Leu Val Ala Leu 
            900                 905                 910         


Gly Ser Arg Lys Ser Ser Val Met Ser Leu Gly Arg Met Ser Tyr Asp 
        915                 920                 925             


Gln Arg Ser Leu Ser Ser Ser Arg Ser Ser Tyr Tyr Gly Pro Trp Gly 
    930                 935                 940                 


Arg Ser Ala Ala Trp Ala Ser Arg Arg Ser Ser Trp Asn Ser Leu Lys 
945                 950                 955                 960 


His Lys Pro Pro Ser Ala Glu His Glu Ser Leu Leu Ser Ala Glu Arg 
                965                 970                 975     


Gly Gly Gly Ala Arg Val Cys Glu Val Ala Ala Asp Glu Gly Pro Pro 
            980                 985                 990         


Arg Ala Ala Pro Leu His Thr Pro  His Ala His His Ile  His His Gly 
        995                 1000                 1005             


Pro His  Leu Ala His Arg His  Arg His His Arg Arg  Thr Leu Ser 
    1010                 1015                 1020             


Leu Asp  Asn Arg Asp Ser Val  Asp Leu Ala Glu Leu  Val Pro Ala 
    1025                 1030                 1035             


Val Gly  Ala His Pro Arg Ala  Ala Trp Arg Ala Ala  Gly Pro Ala 
    1040                 1045                 1050             


Pro Gly  His Glu Asp Cys Asn  Gly Arg Met Pro Ser  Ile Ala Lys 
    1055                 1060                 1065             


Asp Val  Phe Thr Lys Met Gly  Asp Arg Gly Asp Arg  Gly Glu Asp 
    1070                 1075                 1080             


Glu Glu  Glu Ile Asp Tyr Thr  Leu Cys Phe Arg Val  Arg Lys Met 
    1085                 1090                 1095             


Ile Asp  Val Tyr Lys Pro Asp  Trp Cys Glu Val Arg  Glu Asp Trp 
    1100                 1105                 1110             


Ser Val  Tyr Leu Phe Ser Pro  Glu Asn Arg Phe Arg  Val Leu Cys 
    1115                 1120                 1125             


Gln Thr  Ile Ile Ala His Lys  Leu Phe Asp Tyr Val  Val Leu Ala 
    1130                 1135                 1140             


Phe Ile  Phe Leu Asn Cys Ile  Thr Ile Ala Leu Glu  Arg Pro Gln 
    1145                 1150                 1155             


Ile Glu  Ala Gly Ser Thr Glu  Arg Ile Phe Leu Thr  Val Ser Asn 
    1160                 1165                 1170             


Tyr Ile  Phe Thr Ala Ile Phe  Val Gly Glu Met Thr  Leu Lys Val 
    1175                 1180                 1185             


Val Ser  Leu Gly Leu Tyr Phe  Gly Glu Gln Ala Tyr  Leu Arg Ser 
    1190                 1195                 1200             


Ser Trp  Asn Val Leu Asp Gly  Phe Leu Val Phe Val  Ser Ile Ile 
    1205                 1210                 1215             


Asp Ile  Val Val Ser Leu Ala  Ser Ala Gly Gly Ala  Lys Ile Leu 
    1220                 1225                 1230             


Gly Val  Leu Arg Val Leu Arg  Leu Leu Arg Thr Leu  Arg Pro Leu 
    1235                 1240                 1245             


Arg Val  Ile Ser Arg Ala Pro  Gly Leu Lys Leu Val  Val Glu Thr 
    1250                 1255                 1260             


Leu Ile  Ser Ser Leu Lys Pro  Ile Gly Asn Ile Val  Leu Ile Cys 
    1265                 1270                 1275             


Cys Ala  Phe Phe Ile Ile Phe  Gly Ile Leu Gly Val  Gln Leu Phe 
    1280                 1285                 1290             


Lys Gly  Lys Phe Tyr His Cys  Leu Gly Val Asp Thr  Arg Asn Ile 
    1295                 1300                 1305             


Thr Asn  Arg Ser Asp Cys Met  Ala Ala Asn Tyr Arg  Trp Val His 
    1310                 1315                 1320             


His Lys  Tyr Asn Phe Asp Asn  Leu Gly Gln Ala Leu  Met Ser Leu 
    1325                 1330                 1335             


Phe Val  Leu Ala Ser Lys Asp  Gly Trp Val Asn Ile  Met Tyr Asn 
    1340                 1345                 1350             


Gly Leu  Asp Ala Val Ala Val  Asp Gln Gln Pro Val  Thr Asn His 
    1355                 1360                 1365             


Asn Pro  Trp Met Leu Leu Tyr  Phe Ile Ser Phe Leu  Leu Ile Val 
    1370                 1375                 1380             


Ser Phe  Phe Val Leu Asn Met  Phe Val Gly Val Val  Val Glu Asn 
    1385                 1390                 1395             


Phe His  Lys Cys Arg Gln His  Gln Glu Ala Glu Glu  Ala Arg Arg 
    1400                 1405                 1410             


Arg Glu  Glu Lys Arg Leu Arg  Arg Leu Glu Lys Lys  Arg Arg Lys 
    1415                 1420                 1425             


Ala Gln  Arg Leu Pro Tyr Tyr  Ala Thr Tyr Cys His  Thr Arg Leu 
    1430                 1435                 1440             


Leu Ile  His Ser Met Cys Thr  Ser His Tyr Leu Asp  Ile Phe Ile 
    1445                 1450                 1455             


Thr Phe  Ile Ile Cys Leu Asn  Val Val Thr Met Ser  Leu Glu His 
    1460                 1465                 1470             


Tyr Asn  Gln Pro Thr Ser Leu  Glu Thr Ala Leu Lys  Tyr Cys Asn 
    1475                 1480                 1485             


Tyr Met  Phe Thr Thr Val Phe  Val Leu Glu Ala Val  Leu Lys Leu 
    1490                 1495                 1500             


Val Ala  Phe Gly Leu Arg Arg  Phe Phe Lys Asp Arg  Trp Asn Gln 
    1505                 1510                 1515             


Leu Asp  Leu Ala Ile Val Leu  Leu Ser Val Met Gly  Ile Thr Leu 
    1520                 1525                 1530             


Glu Glu  Ile Glu Ile Asn Ala  Ala Leu Pro Ile Asn  Pro Thr Ile 
    1535                 1540                 1545             


Ile Arg  Ile Met Arg Val Leu  Arg Ile Ala Arg Val  Leu Lys Leu 
    1550                 1555                 1560             


Leu Lys  Met Ala Thr Gly Met  Arg Ala Leu Leu Asp  Thr Val Val 
    1565                 1570                 1575             


Gln Ala  Leu Pro Gln Val Gly  Asn Leu Gly Leu Leu  Phe Met Leu 
    1580                 1585                 1590             


Leu Phe  Phe Ile Tyr Ala Ala  Leu Gly Val Glu Leu  Phe Gly Lys 
    1595                 1600                 1605             


Leu Val  Cys Asn Asp Glu Asn  Pro Cys Glu Gly Met  Ser Arg His 
    1610                 1615                 1620             


Ala Thr  Phe Glu Asn Phe Gly  Met Ala Phe Leu Thr  Leu Phe Gln 
    1625                 1630                 1635             


Val Ser  Thr Gly Asp Asn Trp  Asn Gly Ile Met Lys  Asp Thr Leu 
    1640                 1645                 1650             


Arg Asp  Cys Thr His Asp Glu  Arg Ser Cys Leu Ser  Ser Leu Gln 
    1655                 1660                 1665             


Phe Val  Ser Pro Leu Tyr Phe  Val Ser Phe Val Leu  Thr Ala Gln 
    1670                 1675                 1680             


Phe Val  Leu Ile Asn Val Val  Val Ala Val Leu Met  Lys His Leu 
    1685                 1690                 1695             


Asp Asp  Ser Asn Lys Glu Ala  Gln Glu Asp Ala Glu  Met Asp Ala 
    1700                 1705                 1710             


Glu Leu  Glu Leu Glu Met Ala  His Gly Leu Gly Pro  Gly Pro Arg 
    1715                 1720                 1725             


Leu Pro  Thr Gly Ser Pro Gly  Ala Pro Gly Arg Gly  Pro Gly Gly 
    1730                 1735                 1740             


Ala Gly  Gly Gly Gly Asp Thr  Glu Gly Gly Leu Cys  Arg Arg Cys 
    1745                 1750                 1755             


Tyr Ser  Pro Ala Gln Glu Asn  Leu Trp Leu Asp Ser  Val Ser Leu 
    1760                 1765                 1770             


Ile Ile  Lys Asp Ser Leu Glu  Gly Glu Leu Thr Ile  Ile Asp Asn 
    1775                 1780                 1785             


Leu Ser  Gly Ser Ile Phe His  His Tyr Ser Ser Pro  Ala Gly Cys 
    1790                 1795                 1800             


Lys Lys  Cys His His Asp Lys  Gln Glu Val Gln Leu  Ala Glu Thr 
    1805                 1810                 1815             


Glu Ala  Phe Ser Leu Asn Ser  Asp Arg Ser Ser Ser  Ile Leu Leu 
    1820                 1825                 1830             


Gly Asp  Asp Leu Ser Leu Glu  Asp Pro Thr Ala Cys  Pro Pro Gly 
    1835                 1840                 1845             


Arg Lys  Asp Ser Lys Gly Glu  Leu Asp Pro Pro Glu  Pro Met Arg 
    1850                 1855                 1860             


Val Gly  Asp Leu Gly Glu Cys  Phe Phe Pro Leu Ser  Ser Thr Ala 
    1865                 1870                 1875             


Val Ser  Pro Asp Pro Glu Asn  Phe Leu Cys Glu Met  Glu Glu Ile 
    1880                 1885                 1890             


Pro Phe  Asn Pro Val Arg Ser  Trp Leu Lys His Asp  Ser Ser Gln 
    1895                 1900                 1905             


Ala Pro  Pro Ser Pro Phe Ser  Pro Asp Ala Ser Ser  Pro Leu Leu 
    1910                 1915                 1920             


Pro Met  Pro Ala Glu Phe Phe  His Pro Ala Val Ser  Ala Ser Gln 
    1925                 1930                 1935             


Lys Gly  Pro Glu Lys Gly Thr  Gly Thr Gly Thr Leu  Pro Lys Ile 
    1940                 1945                 1950             


Ala Leu  Gln Gly Ser Trp Ala  Ser Leu Arg Ser Pro  Arg Val Asn 
    1955                 1960                 1965             


Cys Thr  Leu Leu Arg Gln Ala  Thr Gly Ser Asp Thr  Ser Leu Asp 
    1970                 1975                 1980             


Ala Ser  Pro Ser Ser Ser Ala  Gly Ser Leu Gln Thr  Thr Leu Glu 
    1985                 1990                 1995             


Asp Ser  Leu Thr Leu Ser Asp  Ser Pro Arg Arg Ala  Leu Gly Pro 
    2000                 2005                 2010             


Pro Ala  Pro Ala Pro Gly Pro  Arg Ala Gly Leu Ser  Pro Ala Ala 
    2015                 2020                 2025             


Arg Arg  Arg Leu Ser Leu Arg  Gly Arg Gly Leu Phe  Ser Leu Arg 
    2030                 2035                 2040             


Gly Leu  Arg Ala His Gln Arg  Ser His Ser Ser Gly  Gly Ser Thr 
    2045                 2050                 2055             


Ser Pro  Gly Cys Thr His His  Asp Ser Met Asp Pro  Ser Asp Glu 
    2060                 2065                 2070             


Glu Gly  Arg Gly Gly Ala Gly  Gly Gly Gly Ala Gly  Ser Glu His 
    2075                 2080                 2085             


Ser Glu  Thr Leu Ser Ser Leu  Ser Leu Thr Ser Leu  Phe Cys Pro 
    2090                 2095                 2100             


Pro Pro  Pro Pro Pro Ala Pro  Gly Leu Thr Pro Ala  Arg Lys Phe 
    2105                 2110                 2115             


Ser Ser  Thr Ser Ser Leu Ala  Ala Pro Gly Arg Pro  His Ala Ala 
    2120                 2125                 2130             


Ala Leu  Ala His Gly Leu Ala  Arg Ser Pro Ser Trp  Ala Ala Asp 
    2135                 2140                 2145             


Arg Ser  Lys Asp Pro Pro Gly  Arg Ala Pro Leu Pro  Met Gly Leu 
    2150                 2155                 2160             


Gly Pro  Leu Ala Pro Pro Pro  Gln Pro Leu Pro Gly  Glu Leu Glu 
    2165                 2170                 2175             


Pro Gly  Asp Ala Ala Ser Lys  Arg Lys Arg 
    2180                 2185             


<210>  409
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  409

Met Ser Ser Ile Leu Pro Phe Thr Pro Pro Val Val Lys Arg Leu Leu 
1               5                   10                  15      


Gly Trp Lys Lys Ser Ala Gly Gly Ser Gly Gly Ala Gly Gly Gly Glu 
            20                  25                  30          


Gln Asn Gly Gln Glu Glu Lys Trp Cys Glu Lys Ala Val Lys Ser Leu 
        35                  40                  45              


Val Lys Lys Leu Lys Lys Thr Gly Arg Leu Asp Glu Leu Glu Lys Ala 
    50                  55                  60                  


Ile Thr Thr Gln Asn Cys Asn Thr Lys Cys Val Thr Ile Pro Ser Thr 
65                  70                  75                  80  


Cys Ser Glu Ile Trp Gly Leu Ser Thr Pro Asn Thr Ile Asp Gln Trp 
                85                  90                  95      


Asp Thr Thr Gly Leu Tyr Ser Phe Ser Glu Gln Thr Arg Ser Leu Asp 
            100                 105                 110         


Gly Arg Leu Gln Val Ser His Arg Lys Gly Leu Pro His Val Ile Tyr 
        115                 120                 125             


Cys Arg Leu Trp Arg Trp Pro Asp Leu His Ser His His Glu Leu Lys 
    130                 135                 140                 


Ala Ile Glu Asn Cys Glu Tyr Ala Phe Asn Leu Lys Lys Asp Glu Val 
145                 150                 155                 160 


Cys Val Asn Pro Tyr His Tyr Gln Arg Val Glu Thr Pro Val Leu Pro 
                165                 170                 175     


Pro Val Leu Val Pro Arg His Thr Glu Ile Leu Thr Glu Leu Pro Pro 
            180                 185                 190         


Leu Asp Asp Tyr Thr His Ser Ile Pro Glu Asn Thr Asn Phe Pro Ala 
        195                 200                 205             


Gly Ile Glu Pro Gln Ser Asn Tyr Ile Pro Glu Thr Pro Pro Pro Gly 
    210                 215                 220                 


Tyr Ile Ser Glu Asp Gly Glu Thr Ser Asp Gln Gln Leu Asn Gln Ser 
225                 230                 235                 240 


Met Asp Thr Gly Ser Pro Ala Glu Leu Ser Pro Thr Thr Leu Ser Pro 
                245                 250                 255     


Val Asn His Ser Leu Asp Leu Gln Pro Val Thr Tyr Ser Glu Pro Ala 
            260                 265                 270         


Phe Trp Cys Ser Ile Ala Tyr Tyr Glu Leu Asn Gln Arg Val Gly Glu 
        275                 280                 285             


Thr Phe His Ala Ser Gln Pro Ser Leu Thr Val Asp Gly Phe Thr Asp 
    290                 295                 300                 


Pro Ser Asn Ser Glu Arg Phe Cys Leu Gly Leu Leu Ser Asn Val Asn 
305                 310                 315                 320 


Arg Asn Ala Thr Val Glu Met Thr Arg Arg His Ile Gly Arg Gly Val 
                325                 330                 335     


Arg Leu Tyr Tyr Ile Gly Gly Glu Val Phe Ala Glu Cys Leu Ser Asp 
            340                 345                 350         


Ser Ala Ile Phe Val Gln Ser Pro Asn Cys Asn Gln Arg Tyr Gly Trp 
        355                 360                 365             


His Pro Ala Thr Val Cys Lys Ile Pro Pro Gly Cys Asn Leu Lys Ile 
    370                 375                 380                 


Phe Asn Asn Gln Glu Phe Ala Ala Leu Leu Ala Gln Ser Val Asn Gln 
385                 390                 395                 400 


Gly Phe Glu Ala Val Tyr Gln Leu Thr Arg Met Cys Thr Ile Arg Met 
                405                 410                 415     


Ser Phe Val Lys Gly Trp Gly Ala Glu Tyr Arg Arg Gln Thr Val Thr 
            420                 425                 430         


Ser Thr Pro Cys Trp Ile Glu Leu His Leu Asn Gly Pro Leu Gln Trp 
        435                 440                 445             


Leu Asp Lys Val Leu Thr Gln Met Gly Ser Pro Ser Val Arg Cys Ser 
    450                 455                 460                 


Ser Met Ser 
465         


<210>  410
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  410

Met Glu Pro Ser His Lys Asp Ala Glu Thr Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Val Ala Ala Ala Asp Pro Arg Gly Ala Ser Ser Ser Ser Gly Val Val 
            20                  25                  30          


Val Gln Val Arg Glu Lys Lys Gly Pro Leu Arg Ala Ala Ile Pro Tyr 
        35                  40                  45              


Met Pro Phe Pro Val Ala Val Ile Cys Leu Phe Leu Asn Thr Phe Val 
    50                  55                  60                  


Pro Gly Leu Gly Thr Phe Val Ser Ala Phe Thr Val Leu Cys Gly Ala 
65                  70                  75                  80  


Arg Thr Asp Leu Pro Asp Arg His Val Cys Cys Val Phe Trp Leu Asn 
                85                  90                  95      


Ile Ala Ala Ala Leu Ile Gln Ile Leu Thr Ala Ile Val Met Val Gly 
            100                 105                 110         


Trp Ile Met Ser Ile Phe Trp Gly Met Asp Met Val Ile Leu Ala Ile 
        115                 120                 125             


Ser Gln Gly Tyr Lys Glu Gln Gly Ile Pro Gln Gln Leu 
    130                 135                 140     


<210>  411
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  411

Met Ser Ser Asp His Leu Asn Asn Ser Thr Leu Lys Glu Ala Gln Phe 
1               5                   10                  15      


Lys Asp Leu Phe Leu Lys Lys Ala Glu Leu Glu Phe Ala Gln Ile Ile 
            20                  25                  30          


Ile Ile Val Val Val Val Thr Val Met Val Val Val Ile Val Cys Leu 
        35                  40                  45              


Leu Asn His Tyr Lys Val Ser Thr Arg Ser Phe Ile Asn Arg Pro Asn 
    50                  55                  60                  


Gln Ser Arg Arg Arg Glu Asp Gly Leu Pro Gln Glu Gly Cys Leu Trp 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Ala Pro Arg Leu Gly Ala Ser Glu Ile Met His 
                85                  90                  95      


Ala Pro Arg Ser Arg Asp Arg Phe Thr Ala Pro Ser Phe Ile Gln Arg 
            100                 105                 110         


Asp Arg Phe Ser Arg Phe Gln Pro Thr Tyr Pro Tyr Val Gln His Glu 
        115                 120                 125             


Ile Asp Leu Pro Pro Thr Ile Ser Leu Ser Asp Gly Glu Glu Pro Pro 
    130                 135                 140                 


Pro Tyr Gln Gly Pro Cys Thr Leu Gln Leu Arg Asp Pro Glu Gln Gln 
145                 150                 155                 160 


Met Glu Leu Asn Arg Glu Ser Val Arg Ala Pro Pro Asn Arg Thr Ile 
                165                 170                 175     


Phe Asp Ser Asp Leu Ile Asp Ile Ala Met Tyr Ser Gly Gly Pro Cys 
            180                 185                 190         


Pro Pro Ser Ser Asn Ser Gly Ile Ser Ala Ser Thr Cys Ser Ser Asn 
        195                 200                 205             


Gly Arg Met Glu Gly Pro Pro Pro Thr Tyr Ser Glu Val Met Gly His 
    210                 215                 220                 


His Pro Gly Ala Ser Phe Leu His His Gln Arg Ser Asn Ala His Arg 
225                 230                 235                 240 


Gly Ser Arg Leu Gln Phe Gln Gln Asn Asn Ala Glu Ser Thr Ile Val 
                245                 250                 255     


Pro Ile Lys Gly Lys Asp Arg Lys Pro Gly Asn Leu Val 
            260                 265                 


<210>  412
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  412

Met Ser Ser Asp His Leu Asn Asn Ser Thr Leu Lys Glu Ala Gln Phe 
1               5                   10                  15      


Lys Asp Leu Phe Leu Lys Lys Ala Glu Leu Glu Phe Ala Gln Ile Ile 
            20                  25                  30          


Ile Ile Val Val Val Val Thr Val Met Val Val Val Ile Val Cys Leu 
        35                  40                  45              


Leu Asn His Tyr Lys Val Ser Thr Arg Ser Phe Ile Asn Arg Pro Asn 
    50                  55                  60                  


Gln Ser Arg Arg Arg Glu Asp Gly Leu Pro Gln Ile Met His Ala Pro 
65                  70                  75                  80  


Arg Ser Arg Asp Arg Phe Thr Ala Pro Ser Phe Ile Gln Arg Asp Arg 
                85                  90                  95      


Phe Ser Arg Phe Gln Pro Thr Tyr Pro Tyr Val Gln His Glu Ile Asp 
            100                 105                 110         


Leu Pro Pro Thr Ile Ser Leu Ser Asp Gly Glu Glu Pro Pro Pro Tyr 
        115                 120                 125             


Gln Gly Pro Cys Thr Leu Gln Leu Arg Asp Pro Glu Gln Gln Met Glu 
    130                 135                 140                 


Leu Asn Arg Glu Ser Val Arg Ala Pro Pro Asn Arg Thr Ile Phe Asp 
145                 150                 155                 160 


Ser Asp Leu Ile Asp Ile Ala Met Tyr Ser Gly Gly Pro Cys Pro Pro 
                165                 170                 175     


Ser Ser Asn Ser Gly Ile Ser Ala Ser Thr Cys Ser Ser Asn Gly Arg 
            180                 185                 190         


Met Glu Gly Pro Pro Pro Thr Tyr Ser Glu Val Met Gly His His Pro 
        195                 200                 205             


Gly Ala Ser Phe Leu His His Gln Arg Ser Asn Ala His Arg Gly Ser 
    210                 215                 220                 


Arg Leu Gln Phe Gln Gln Asn Asn Ala Glu Ser Thr Ile Val Pro Ile 
225                 230                 235                 240 


Lys Gly Lys Asp Arg Lys Pro Gly Asn Leu Val 
                245                 250     


<210>  413
<211>  896
<212>  PRT
<213>  Homo sapiens

<400>  413

Met Ile Cys Gln Lys Phe Cys Val Val Leu Leu His Trp Glu Phe Ile 
1               5                   10                  15      


Tyr Val Ile Thr Ala Phe Asn Leu Ser Tyr Pro Ile Thr Pro Trp Arg 
            20                  25                  30          


Phe Lys Leu Ser Cys Met Pro Pro Asn Ser Thr Tyr Asp Tyr Phe Leu 
        35                  40                  45              


Leu Pro Ala Gly Leu Ser Lys Asn Thr Ser Asn Ser Asn Gly His Tyr 
    50                  55                  60                  


Glu Thr Ala Val Glu Pro Lys Phe Asn Ser Ser Gly Thr His Phe Ser 
65                  70                  75                  80  


Asn Leu Ser Lys Thr Thr Phe His Cys Cys Phe Arg Ser Glu Gln Asp 
                85                  90                  95      


Arg Asn Cys Ser Leu Cys Ala Asp Asn Ile Glu Gly Lys Thr Phe Val 
            100                 105                 110         


Ser Thr Val Asn Ser Leu Val Phe Gln Gln Ile Asp Ala Asn Trp Asn 
        115                 120                 125             


Ile Gln Cys Trp Leu Lys Gly Asp Leu Lys Leu Phe Ile Cys Tyr Val 
    130                 135                 140                 


Glu Ser Leu Phe Lys Asn Leu Phe Arg Asn Tyr Asn Tyr Lys Val His 
145                 150                 155                 160 


Leu Leu Tyr Val Leu Pro Glu Val Leu Glu Asp Ser Pro Leu Val Pro 
                165                 170                 175     


Gln Lys Gly Ser Phe Gln Met Val His Cys Asn Cys Ser Val His Glu 
            180                 185                 190         


Cys Cys Glu Cys Leu Val Pro Val Pro Thr Ala Lys Leu Asn Asp Thr 
        195                 200                 205             


Leu Leu Met Cys Leu Lys Ile Thr Ser Gly Gly Val Ile Phe Gln Ser 
    210                 215                 220                 


Pro Leu Met Ser Val Gln Pro Ile Asn Met Val Lys Pro Asp Pro Pro 
225                 230                 235                 240 


Leu Gly Leu His Met Glu Ile Thr Asp Asp Gly Asn Leu Lys Ile Ser 
                245                 250                 255     


Trp Ser Ser Pro Pro Leu Val Pro Phe Pro Leu Gln Tyr Gln Val Lys 
            260                 265                 270         


Tyr Ser Glu Asn Ser Thr Thr Val Ile Arg Glu Ala Asp Lys Ile Val 
        275                 280                 285             


Ser Ala Thr Ser Leu Leu Val Asp Ser Ile Leu Pro Gly Ser Ser Tyr 
    290                 295                 300                 


Glu Val Gln Val Arg Gly Lys Arg Leu Asp Gly Pro Gly Ile Trp Ser 
305                 310                 315                 320 


Asp Trp Ser Thr Pro Arg Val Phe Thr Thr Gln Asp Val Ile Tyr Phe 
                325                 330                 335     


Pro Pro Lys Ile Leu Thr Ser Val Gly Ser Asn Val Ser Phe His Cys 
            340                 345                 350         


Ile Tyr Lys Lys Glu Asn Lys Ile Val Pro Ser Lys Glu Ile Val Trp 
        355                 360                 365             


Trp Met Asn Leu Ala Glu Lys Ile Pro Gln Ser Gln Tyr Asp Val Val 
    370                 375                 380                 


Ser Asp His Val Ser Lys Val Thr Phe Phe Asn Leu Asn Glu Thr Lys 
385                 390                 395                 400 


Pro Arg Gly Lys Phe Thr Tyr Asp Ala Val Tyr Cys Cys Asn Glu His 
                405                 410                 415     


Glu Cys His His Arg Tyr Ala Glu Leu Tyr Val Ile Asp Val Asn Ile 
            420                 425                 430         


Asn Ile Ser Cys Glu Thr Asp Gly Tyr Leu Thr Lys Met Thr Cys Arg 
        435                 440                 445             


Trp Ser Thr Ser Thr Ile Gln Ser Leu Ala Glu Ser Thr Leu Gln Leu 
    450                 455                 460                 


Arg Tyr His Arg Ser Ser Leu Tyr Cys Ser Asp Ile Pro Ser Ile His 
465                 470                 475                 480 


Pro Ile Ser Glu Pro Lys Asp Cys Tyr Leu Gln Ser Asp Gly Phe Tyr 
                485                 490                 495     


Glu Cys Ile Phe Gln Pro Ile Phe Leu Leu Ser Gly Tyr Thr Met Trp 
            500                 505                 510         


Ile Arg Ile Asn His Ser Leu Gly Ser Leu Asp Ser Pro Pro Thr Cys 
        515                 520                 525             


Val Leu Pro Asp Ser Val Val Lys Pro Leu Pro Pro Ser Ser Val Lys 
    530                 535                 540                 


Ala Glu Ile Thr Ile Asn Ile Gly Leu Leu Lys Ile Ser Trp Glu Lys 
545                 550                 555                 560 


Pro Val Phe Pro Glu Asn Asn Leu Gln Phe Gln Ile Arg Tyr Gly Leu 
                565                 570                 575     


Ser Gly Lys Glu Val Gln Trp Lys Met Tyr Glu Val Tyr Asp Ala Lys 
            580                 585                 590         


Ser Lys Ser Val Ser Leu Pro Val Pro Asp Leu Cys Ala Val Tyr Ala 
        595                 600                 605             


Val Gln Val Arg Cys Lys Arg Leu Asp Gly Leu Gly Tyr Trp Ser Asn 
    610                 615                 620                 


Trp Ser Asn Pro Ala Tyr Thr Val Val Met Asp Ile Lys Val Pro Met 
625                 630                 635                 640 


Arg Gly Pro Glu Phe Trp Arg Ile Ile Asn Gly Asp Thr Met Lys Lys 
                645                 650                 655     


Glu Lys Asn Val Thr Leu Leu Trp Lys Pro Leu Met Lys Asn Asp Ser 
            660                 665                 670         


Leu Cys Ser Val Gln Arg Tyr Val Ile Asn His His Thr Ser Cys Asn 
        675                 680                 685             


Gly Thr Trp Ser Glu Asp Val Gly Asn His Thr Lys Phe Thr Phe Leu 
    690                 695                 700                 


Trp Thr Glu Gln Ala His Thr Val Thr Val Leu Ala Ile Asn Ser Ile 
705                 710                 715                 720 


Gly Ala Ser Val Ala Asn Phe Asn Leu Thr Phe Ser Trp Pro Met Ser 
                725                 730                 735     


Lys Val Asn Ile Val Gln Ser Leu Ser Ala Tyr Pro Leu Asn Ser Ser 
            740                 745                 750         


Cys Val Ile Val Ser Trp Ile Leu Ser Pro Ser Asp Tyr Lys Leu Met 
        755                 760                 765             


Tyr Phe Ile Ile Glu Trp Lys Asn Leu Asn Glu Asp Gly Glu Ile Lys 
    770                 775                 780                 


Trp Leu Arg Ile Ser Ser Ser Val Lys Lys Tyr Tyr Ile His Asp His 
785                 790                 795                 800 


Phe Ile Pro Ile Glu Lys Tyr Gln Phe Ser Leu Tyr Pro Ile Phe Met 
                805                 810                 815     


Glu Gly Val Gly Lys Pro Lys Ile Ile Asn Ser Phe Thr Gln Asp Asp 
            820                 825                 830         


Ile Glu Lys His Gln Ser Asp Ala Gly Leu Tyr Val Ile Val Pro Val 
        835                 840                 845             


Ile Ile Ser Ser Ser Ile Leu Leu Leu Gly Thr Leu Leu Ile Ser His 
    850                 855                 860                 


Gln Arg Met Lys Lys Leu Phe Trp Glu Asp Val Pro Asn Pro Lys Asn 
865                 870                 875                 880 


Cys Ser Trp Ala Gln Gly Leu Asn Phe Gln Lys Arg Thr Asp Ile Leu 
                885                 890                 895     


<210>  414
<211>  958
<212>  PRT
<213>  Homo sapiens

<400>  414

Met Ile Cys Gln Lys Phe Cys Val Val Leu Leu His Trp Glu Phe Ile 
1               5                   10                  15      


Tyr Val Ile Thr Ala Phe Asn Leu Ser Tyr Pro Ile Thr Pro Trp Arg 
            20                  25                  30          


Phe Lys Leu Ser Cys Met Pro Pro Asn Ser Thr Tyr Asp Tyr Phe Leu 
        35                  40                  45              


Leu Pro Ala Gly Leu Ser Lys Asn Thr Ser Asn Ser Asn Gly His Tyr 
    50                  55                  60                  


Glu Thr Ala Val Glu Pro Lys Phe Asn Ser Ser Gly Thr His Phe Ser 
65                  70                  75                  80  


Asn Leu Ser Lys Thr Thr Phe His Cys Cys Phe Arg Ser Glu Gln Asp 
                85                  90                  95      


Arg Asn Cys Ser Leu Cys Ala Asp Asn Ile Glu Gly Lys Thr Phe Val 
            100                 105                 110         


Ser Thr Val Asn Ser Leu Val Phe Gln Gln Ile Asp Ala Asn Trp Asn 
        115                 120                 125             


Ile Gln Cys Trp Leu Lys Gly Asp Leu Lys Leu Phe Ile Cys Tyr Val 
    130                 135                 140                 


Glu Ser Leu Phe Lys Asn Leu Phe Arg Asn Tyr Asn Tyr Lys Val His 
145                 150                 155                 160 


Leu Leu Tyr Val Leu Pro Glu Val Leu Glu Asp Ser Pro Leu Val Pro 
                165                 170                 175     


Gln Lys Gly Ser Phe Gln Met Val His Cys Asn Cys Ser Val His Glu 
            180                 185                 190         


Cys Cys Glu Cys Leu Val Pro Val Pro Thr Ala Lys Leu Asn Asp Thr 
        195                 200                 205             


Leu Leu Met Cys Leu Lys Ile Thr Ser Gly Gly Val Ile Phe Gln Ser 
    210                 215                 220                 


Pro Leu Met Ser Val Gln Pro Ile Asn Met Val Lys Pro Asp Pro Pro 
225                 230                 235                 240 


Leu Gly Leu His Met Glu Ile Thr Asp Asp Gly Asn Leu Lys Ile Ser 
                245                 250                 255     


Trp Ser Ser Pro Pro Leu Val Pro Phe Pro Leu Gln Tyr Gln Val Lys 
            260                 265                 270         


Tyr Ser Glu Asn Ser Thr Thr Val Ile Arg Glu Ala Asp Lys Ile Val 
        275                 280                 285             


Ser Ala Thr Ser Leu Leu Val Asp Ser Ile Leu Pro Gly Ser Ser Tyr 
    290                 295                 300                 


Glu Val Gln Val Arg Gly Lys Arg Leu Asp Gly Pro Gly Ile Trp Ser 
305                 310                 315                 320 


Asp Trp Ser Thr Pro Arg Val Phe Thr Thr Gln Asp Val Ile Tyr Phe 
                325                 330                 335     


Pro Pro Lys Ile Leu Thr Ser Val Gly Ser Asn Val Ser Phe His Cys 
            340                 345                 350         


Ile Tyr Lys Lys Glu Asn Lys Ile Val Pro Ser Lys Glu Ile Val Trp 
        355                 360                 365             


Trp Met Asn Leu Ala Glu Lys Ile Pro Gln Ser Gln Tyr Asp Val Val 
    370                 375                 380                 


Ser Asp His Val Ser Lys Val Thr Phe Phe Asn Leu Asn Glu Thr Lys 
385                 390                 395                 400 


Pro Arg Gly Lys Phe Thr Tyr Asp Ala Val Tyr Cys Cys Asn Glu His 
                405                 410                 415     


Glu Cys His His Arg Tyr Ala Glu Leu Tyr Val Ile Asp Val Asn Ile 
            420                 425                 430         


Asn Ile Ser Cys Glu Thr Asp Gly Tyr Leu Thr Lys Met Thr Cys Arg 
        435                 440                 445             


Trp Ser Thr Ser Thr Ile Gln Ser Leu Ala Glu Ser Thr Leu Gln Leu 
    450                 455                 460                 


Arg Tyr His Arg Ser Ser Leu Tyr Cys Ser Asp Ile Pro Ser Ile His 
465                 470                 475                 480 


Pro Ile Ser Glu Pro Lys Asp Cys Tyr Leu Gln Ser Asp Gly Phe Tyr 
                485                 490                 495     


Glu Cys Ile Phe Gln Pro Ile Phe Leu Leu Ser Gly Tyr Thr Met Trp 
            500                 505                 510         


Ile Arg Ile Asn His Ser Leu Gly Ser Leu Asp Ser Pro Pro Thr Cys 
        515                 520                 525             


Val Leu Pro Asp Ser Val Val Lys Pro Leu Pro Pro Ser Ser Val Lys 
    530                 535                 540                 


Ala Glu Ile Thr Ile Asn Ile Gly Leu Leu Lys Ile Ser Trp Glu Lys 
545                 550                 555                 560 


Pro Val Phe Pro Glu Asn Asn Leu Gln Phe Gln Ile Arg Tyr Gly Leu 
                565                 570                 575     


Ser Gly Lys Glu Val Gln Trp Lys Met Tyr Glu Val Tyr Asp Ala Lys 
            580                 585                 590         


Ser Lys Ser Val Ser Leu Pro Val Pro Asp Leu Cys Ala Val Tyr Ala 
        595                 600                 605             


Val Gln Val Arg Cys Lys Arg Leu Asp Gly Leu Gly Tyr Trp Ser Asn 
    610                 615                 620                 


Trp Ser Asn Pro Ala Tyr Thr Val Val Met Asp Ile Lys Val Pro Met 
625                 630                 635                 640 


Arg Gly Pro Glu Phe Trp Arg Ile Ile Asn Gly Asp Thr Met Lys Lys 
                645                 650                 655     


Glu Lys Asn Val Thr Leu Leu Trp Lys Pro Leu Met Lys Asn Asp Ser 
            660                 665                 670         


Leu Cys Ser Val Gln Arg Tyr Val Ile Asn His His Thr Ser Cys Asn 
        675                 680                 685             


Gly Thr Trp Ser Glu Asp Val Gly Asn His Thr Lys Phe Thr Phe Leu 
    690                 695                 700                 


Trp Thr Glu Gln Ala His Thr Val Thr Val Leu Ala Ile Asn Ser Ile 
705                 710                 715                 720 


Gly Ala Ser Val Ala Asn Phe Asn Leu Thr Phe Ser Trp Pro Met Ser 
                725                 730                 735     


Lys Val Asn Ile Val Gln Ser Leu Ser Ala Tyr Pro Leu Asn Ser Ser 
            740                 745                 750         


Cys Val Ile Val Ser Trp Ile Leu Ser Pro Ser Asp Tyr Lys Leu Met 
        755                 760                 765             


Tyr Phe Ile Ile Glu Trp Lys Asn Leu Asn Glu Asp Gly Glu Ile Lys 
    770                 775                 780                 


Trp Leu Arg Ile Ser Ser Ser Val Lys Lys Tyr Tyr Ile His Asp His 
785                 790                 795                 800 


Phe Ile Pro Ile Glu Lys Tyr Gln Phe Ser Leu Tyr Pro Ile Phe Met 
                805                 810                 815     


Glu Gly Val Gly Lys Pro Lys Ile Ile Asn Ser Phe Thr Gln Asp Asp 
            820                 825                 830         


Ile Glu Lys His Gln Ser Asp Ala Gly Leu Tyr Val Ile Val Pro Val 
        835                 840                 845             


Ile Ile Ser Ser Ser Ile Leu Leu Leu Gly Thr Leu Leu Ile Ser His 
    850                 855                 860                 


Gln Arg Met Lys Lys Leu Phe Trp Glu Asp Val Pro Asn Pro Lys Asn 
865                 870                 875                 880 


Cys Ser Trp Ala Gln Gly Leu Asn Phe Gln Lys Met Leu Glu Gly Ser 
                885                 890                 895     


Met Phe Val Lys Ser His His His Ser Leu Ile Ser Ser Thr Gln Gly 
            900                 905                 910         


His Lys His Cys Gly Arg Pro Gln Gly Pro Leu His Arg Lys Thr Arg 
        915                 920                 925             


Asp Leu Cys Ser Leu Val Tyr Leu Leu Thr Leu Pro Pro Leu Leu Ser 
    930                 935                 940                 


Tyr Asp Pro Ala Lys Ser Pro Ser Val Arg Asn Thr Gln Glu 
945                 950                 955             


<210>  415
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  415

Met Thr Ala Gly Ser Pro Glu Glu Cys Gly Glu Val Arg Arg Ser Pro 
1               5                   10                  15      


Glu Gly Arg Val Ser Arg Leu Gly Arg Arg Leu Gly Arg Arg Arg Arg 
            20                  25                  30          


Pro Arg Ser Pro Pro Glu Pro Leu Arg Val Arg Ala Arg Leu Arg Leu 
        35                  40                  45              


Arg Ser Pro Ser Gly Ala Phe Ala Ala Leu Gly Ala Leu Val Val Leu 
    50                  55                  60                  


Val Gly Met Gly Ile Ala Val Ala Gly Tyr Trp Pro His Arg Ala Gly 
65                  70                  75                  80  


Ala Pro Gly Ser Arg Ala Ala Asn Ala Ser Ser Pro Gln Met Ser Glu 
                85                  90                  95      


Leu Arg Arg Glu Gly Arg Gly Gly Gly Arg Ala His Gly Pro His Glu 
            100                 105                 110         


Arg Leu Arg Leu Leu Gly Pro Val Ile Met Gly Val Gly Leu Phe Val 
        115                 120                 125             


Phe Ile Cys Ala Asn Thr Leu Leu Tyr Glu Asn Arg Asp Leu Glu Thr 
    130                 135                 140                 


Arg Arg Leu Arg Gln Gly Val Leu Arg Ala Gln Ala Leu Arg Pro Pro 
145                 150                 155                 160 


Asp Gly Pro Gly Trp Asp Cys Ala Leu Leu Pro Ser Pro Gly Pro Arg 
                165                 170                 175     


Ser Pro Arg Ala Val Gly Cys Ala Glu Pro Glu Ile Trp Asp Pro Ser 
            180                 185                 190         


Pro Arg Arg Gly Thr Ser Pro Val Pro Ser Val Arg Ser Leu Arg Ser 
        195                 200                 205             


Glu Pro Ala Asn Pro Arg Leu Gly Leu Pro Ala Leu Leu Asn Ser Tyr 
    210                 215                 220                 


Pro Leu Lys Gly Pro Gly Leu Pro Pro Pro Trp Gly Pro Arg Thr Gln 
225                 230                 235                 240 


Thr Gly His Val Ile Ile Thr Val Gln Pro Ser Gly Ser Cys Ile Glu 
                245                 250                 255     


His Ser Lys Ser Leu Asp Leu Gly Leu Gly Glu Leu Leu Leu Gly Ala 
            260                 265                 270         


Pro Ala Ala Arg Asp Cys Ala His Arg Ser Trp Pro Arg Leu Asp Arg 
        275                 280                 285             


Leu Ser Leu Gly Gly Tyr Ala Lys Leu Gly Gly Gly Gly Asp Leu Gly 
    290                 295                 300                 


Ala Arg Val 
305         


<210>  416
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  416

Met Ala Val Leu Phe Leu Leu Leu Phe Leu Cys Gly Thr Pro Gln Ala 
1               5                   10                  15      


Ala Asp Asn Met Gln Ala Ile Tyr Val Ala Leu Gly Glu Ala Val Glu 
            20                  25                  30          


Leu Pro Cys Pro Ser Pro Pro Thr Leu His Gly Asp Glu His Leu Ser 
        35                  40                  45              


Trp Phe Cys Ser Pro Ala Ala Gly Ser Phe Thr Thr Leu Val Ala Gln 
    50                  55                  60                  


Val Gln Val Gly Arg Pro Ala Pro Asp Pro Gly Lys Pro Gly Arg Glu 
65                  70                  75                  80  


Ser Arg Leu Arg Leu Leu Gly Asn Tyr Ser Leu Trp Leu Glu Gly Ser 
                85                  90                  95      


Lys Glu Glu Asp Ala Gly Arg Tyr Trp Cys Ala Val Leu Gly Gln His 
            100                 105                 110         


His Asn Tyr Gln Asn Trp Arg Val Tyr Asp Val Leu Val Leu Lys Gly 
        115                 120                 125             


Ser Gln Leu Ser Ala Arg Ala Ala Asp Gly Ser Pro Cys Asn Val Leu 
    130                 135                 140                 


Leu Cys Ser Val Val Pro Ser Arg Arg Met Asp Ser Val Thr Trp Gln 
145                 150                 155                 160 


Glu Gly Lys Gly Pro Val Arg Gly Arg Val Gln Ser Phe Trp Gly Ser 
                165                 170                 175     


Glu Ala Ala Leu Leu Leu Val Cys Pro Gly Glu Gly Leu Ser Glu Pro 
            180                 185                 190         


Arg Ser Arg Arg Pro Arg Ile Ile Arg Cys Leu Met Thr His Asn Lys 
        195                 200                 205             


Gly Val Ser Phe Ser Leu Ala Ala Ser Ile Asp Ala Ser Pro Ala Leu 
    210                 215                 220                 


Cys Ala Pro Ser Thr Gly Trp Asp Met Pro Trp Ile Leu Met Leu Leu 
225                 230                 235                 240 


Leu Thr Met Gly Gln Gly Val Val Ile Leu Ala Leu Ser Ile Val Leu 
                245                 250                 255     


Trp Arg Gln Arg Val Arg Gly Ala Pro Gly Arg Asp Ala Ser Ile Pro 
            260                 265                 270         


Gln Phe Lys Pro Glu Ile Gln Val Tyr Glu Asn Ile His Leu Ala Arg 
        275                 280                 285             


Leu Gly Pro Pro Ala His Lys Pro Arg 
    290                 295         


<210>  417
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  417

Met Lys Pro Gln Phe Val Gly Ile Leu Leu Ser Ser Leu Leu Gly Ala 
1               5                   10                  15      


Ala Leu Gly Asn Arg Met Arg Cys Tyr Asn Cys Gly Gly Ser Pro Ser 
            20                  25                  30          


Ser Ser Cys Lys Glu Ala Val Thr Thr Cys Gly Glu Gly Arg Pro Gln 
        35                  40                  45              


Pro Gly Leu Glu Gln Ile Lys Leu Pro Gly Asn Pro Pro Val Thr Leu 
    50                  55                  60                  


Ile His Gln His Pro Ala Cys Val Ala Ala His His Cys Asn Gln Val 
65                  70                  75                  80  


Glu Thr Glu Ser Val Gly Asp Val Thr Tyr Pro Ala His Arg Asp Cys 
                85                  90                  95      


Tyr Leu Gly Asp Leu Cys Asn Ser Ala Val Ala Ser His Val Ala Pro 
            100                 105                 110         


Ala Gly Ile Leu Ala Ala Ala Ala Thr Ala Leu Thr Cys Leu Leu Pro 
        115                 120                 125             


Gly Leu Trp Ser Gly 
    130             


<210>  418
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  418

Met Ser Glu Pro Gln Pro Arg Gly Ala Glu Arg Asp Leu Tyr Arg Asp 
1               5                   10                  15      


Thr Trp Val Arg Tyr Leu Gly Tyr Ala Asn Glu Val Gly Glu Ala Phe 
            20                  25                  30          


Arg Ser Leu Val Pro Ala Ala Val Val Trp Leu Ser Tyr Gly Val Ala 
        35                  40                  45              


Ser Ser Tyr Val Leu Ala Asp Ala Ile Asp Lys Gly Lys Lys Ala Gly 
    50                  55                  60                  


Glu Val Gly Gly Phe Pro Pro Gly Leu Gln Pro Ala Gln Ala Leu Pro 
65                  70                  75                  80  


Asn Ser Gly Glu Ala Gln Leu Leu Leu Ile Ile Leu Trp Tyr Leu Ala 
                85                  90                  95      


Cys Ala Ser Ala Ser Cys Phe Met Ser Thr Ser Tyr Ser Cys Gln Gly 
            100                 105                 110         


Met Trp Thr Pro Gly Ser Leu Val Ser Lys Asp Pro Gly Thr Trp Val 
        115                 120                 125             


Gly Leu Ser Trp Thr Glu Ala 
    130                 135 


<210>  419
<211>  847
<212>  PRT
<213>  Homo sapiens

<400>  419

Met Ser Gln Arg Gln Gly Lys Glu Ala Tyr Pro Thr Pro Thr Lys Asp 
1               5                   10                  15      


Leu His Gln Pro Ser Leu Ser Pro Ala Ser Pro His Ser Gln Gly Phe 
            20                  25                  30          


Glu Arg Gly Lys Glu Asp Ile Ser Gln Asn Lys Asp Glu Ser Ser Leu 
        35                  40                  45              


Ser Met Ser Lys Ser Lys Ser Glu Ser Lys Leu Tyr Asn Gly Ser Glu 
    50                  55                  60                  


Lys Asp Ser Ser Thr Ser Ser Lys Leu Thr Lys Lys Glu Ser Leu Lys 
65                  70                  75                  80  


Val Gln Lys Lys Asn Tyr Arg Glu Glu Lys Lys Arg Ala Thr Lys Glu 
                85                  90                  95      


Leu Leu Ser Thr Ile Thr Asp Pro Ser Val Ile Val Met Ala Asp Trp 
            100                 105                 110         


Leu Lys Ile Arg Gly Thr Leu Lys Ser Trp Thr Lys Leu Trp Cys Val 
        115                 120                 125             


Leu Lys Pro Gly Val Leu Leu Ile Tyr Lys Thr Gln Lys Asn Gly Gln 
    130                 135                 140                 


Trp Val Gly Thr Val Leu Leu Asn Ala Cys Glu Ile Ile Glu Arg Pro 
145                 150                 155                 160 


Ser Lys Lys Asp Gly Phe Cys Phe Lys Leu Phe His Pro Leu Glu Gln 
                165                 170                 175     


Ser Ile Trp Ala Val Lys Gly Pro Lys Gly Glu Ala Val Gly Ser Ile 
            180                 185                 190         


Thr Gln Pro Leu Pro Ser Ser Tyr Leu Ile Ile Arg Ala Thr Ser Glu 
        195                 200                 205             


Ser Asp Gly Arg Cys Trp Met Asp Ala Leu Glu Leu Ala Leu Lys Cys 
    210                 215                 220                 


Ser Ser Leu Leu Lys Arg Thr Met Ile Arg Glu Gly Lys Glu His Asp 
225                 230                 235                 240 


Leu Ser Val Ser Ser Asp Ser Thr His Val Thr Phe Tyr Gly Leu Leu 
                245                 250                 255     


Arg Ala Asn Asn Leu His Ser Gly Asp Asn Phe Gln Leu Asn Asp Ser 
            260                 265                 270         


Glu Ile Glu Arg Gln His Phe Lys Asp Gln Asp Met Tyr Ser Asp Lys 
        275                 280                 285             


Ser Asp Lys Glu Asn Asp Gln Glu His Asp Glu Ser Asp Asn Glu Val 
    290                 295                 300                 


Met Gly Lys Ser Glu Glu Ser Asp Thr Asp Thr Ser Glu Arg Gln Asp 
305                 310                 315                 320 


Asp Ser Tyr Ile Glu Pro Glu Pro Val Glu Pro Leu Lys Glu Thr Thr 
                325                 330                 335     


Tyr Thr Glu Gln Ser His Glu Glu Leu Gly Glu Ala Gly Glu Ala Ser 
            340                 345                 350         


Gln Thr Glu Thr Val Ser Glu Glu Asn Lys Ser Leu Ile Trp Thr Leu 
        355                 360                 365             


Leu Lys Gln Val Arg Pro Gly Met Asp Leu Ser Lys Val Val Leu Pro 
    370                 375                 380                 


Thr Phe Ile Leu Glu Pro Arg Ser Phe Leu Asp Lys Leu Ser Asp Tyr 
385                 390                 395                 400 


Tyr Tyr His Ala Asp Phe Leu Ser Glu Ala Ala Leu Glu Glu Asn Pro 
                405                 410                 415     


Tyr Phe Arg Leu Lys Lys Val Val Lys Trp Tyr Leu Ser Gly Phe Tyr 
            420                 425                 430         


Lys Lys Pro Lys Gly Leu Lys Lys Pro Tyr Asn Pro Ile Leu Gly Glu 
        435                 440                 445             


Thr Phe Arg Cys Leu Trp Ile His Pro Arg Thr Asn Ser Lys Thr Phe 
    450                 455                 460                 


Tyr Ile Ala Glu Gln Val Ser His His Pro Pro Ile Ser Ala Phe Tyr 
465                 470                 475                 480 


Val Ser Asn Arg Lys Asp Gly Phe Cys Leu Ser Gly Ser Ile Leu Ala 
                485                 490                 495     


Lys Ser Lys Phe Tyr Gly Asn Ser Leu Ser Ala Ile Leu Glu Gly Glu 
            500                 505                 510         


Ala Arg Leu Thr Phe Leu Asn Arg Gly Glu Asp Tyr Val Met Thr Met 
        515                 520                 525             


Pro Tyr Ala His Cys Lys Gly Ile Leu Tyr Gly Thr Met Thr Leu Glu 
    530                 535                 540                 


Leu Gly Gly Thr Val Asn Ile Thr Cys Gln Lys Thr Gly Tyr Ser Ala 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Lys Pro Phe Leu Gly Ser Ser Asp Cys Val 
                565                 570                 575     


Asn Gln Ile Ser Gly Lys Leu Lys Leu Gly Lys Glu Val Leu Ala Thr 
            580                 585                 590         


Leu Glu Gly His Trp Asp Ser Glu Val Phe Ile Thr Asp Lys Lys Thr 
        595                 600                 605             


Asp Asn Ser Glu Val Phe Trp Asn Pro Thr Pro Asp Ile Lys Gln Trp 
    610                 615                 620                 


Arg Leu Ile Arg His Thr Val Lys Phe Glu Glu Gln Gly Asp Phe Glu 
625                 630                 635                 640 


Ser Glu Lys Leu Trp Gln Arg Val Thr Arg Ala Ile Asn Ala Lys Asp 
                645                 650                 655     


Gln Thr Glu Ala Thr Gln Glu Lys Tyr Val Leu Glu Glu Ala Gln Arg 
            660                 665                 670         


Gln Ala Ala Arg Asp Arg Lys Thr Lys Asn Glu Glu Trp Ser Cys Lys 
        675                 680                 685             


Leu Phe Glu Leu Asp Pro Leu Thr Gly Glu Trp His Tyr Lys Phe Ala 
    690                 695                 700                 


Asp Thr Arg Pro Trp Asp Pro Leu Asn Asp Met Ile Gln Phe Glu Lys 
705                 710                 715                 720 


Asp Gly Val Ile Gln Thr Lys Val Lys His Arg Thr Pro Met Val Ser 
                725                 730                 735     


Val Pro Lys Met Lys His Lys Pro Thr Arg Gln Gln Lys Lys Val Ala 
            740                 745                 750         


Lys Gly Tyr Ser Ser Pro Glu Pro Asp Ile Gln Asp Ser Ser Gly Ser 
        755                 760                 765             


Glu Ala Gln Ser Val Lys Pro Ser Thr Arg Arg Lys Lys Gly Ile Glu 
    770                 775                 780                 


Leu Gly Asp Ile Gln Ser Ser Ile Glu Ser Ile Lys Gln Thr Gln Glu 
785                 790                 795                 800 


Glu Ile Lys Arg Asn Ile Met Ala Leu Arg Asn His Leu Val Ser Ser 
                805                 810                 815     


Thr Pro Ala Thr Asp Tyr Phe Leu Gln Gln Lys Asp Tyr Phe Ile Ile 
            820                 825                 830         


Phe Leu Leu Ile Leu Leu Gln Val Ile Ile Asn Phe Met Phe Lys 
        835                 840                 845         


<210>  420
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  420

Met Ala Ser Val Val Pro Val Lys Asp Lys Lys Leu Leu Glu Val Lys 
1               5                   10                  15      


Leu Gly Glu Leu Pro Ser Trp Ile Leu Met Arg Asp Phe Ser Pro Ser 
            20                  25                  30          


Gly Ile Phe Gly Ala Phe Gln Arg Gly Tyr Tyr Arg Tyr Tyr Asn Lys 
        35                  40                  45              


Tyr Ile Asn Val Lys Lys Gly Ser Ile Ser Gly Ile Thr Met Val Leu 
    50                  55                  60                  


Ala Cys Tyr Val Leu Phe Ser Tyr Ser Phe Ser Tyr Lys His Leu Lys 
65                  70                  75                  80  


His Glu Arg Leu Arg Lys Tyr His 
                85              


<210>  421
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  421

Met Ala Ser Val Gly Glu Cys Pro Ala Pro Val Pro Val Lys Asp Lys 
1               5                   10                  15      


Lys Leu Leu Glu Val Lys Leu Gly Glu Leu Pro Ser Trp Ile Leu Met 
            20                  25                  30          


Arg Asp Phe Ser Pro Ser Gly Ile Phe Gly Ala Phe Gln Arg Glu His 
        35                  40                  45              


Glu Arg Leu Arg Lys Tyr His 
    50                  55  


<210>  422
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  422

Met Lys Arg Gln Asn Gln Ser Cys Val Val Glu Phe Ile Leu Leu Gly 
1               5                   10                  15      


Phe Ser Asn Phe Pro Glu Leu Gln Val Gln Leu Phe Gly Val Phe Leu 
            20                  25                  30          


Val Ile Tyr Val Val Thr Leu Met Gly Asn Ala Ile Ile Thr Val Ile 
        35                  40                  45              


Ile Ser Leu Asn Gln Ser Leu His Val Pro Met Tyr Leu Phe Leu Leu 
    50                  55                  60                  


Asn Leu Ser Val Val Glu Val Ser Phe Ser Ala Val Ile Thr Pro Glu 
65                  70                  75                  80  


Met Leu Val Val Leu Ser Thr Glu Lys Thr Met Ile Ser Phe Val Gly 
                85                  90                  95      


Cys Phe Ala Gln Met Tyr Phe Ile Leu Leu Phe Gly Gly Thr Glu Cys 
            100                 105                 110         


Phe Leu Leu Gly Ala Met Ala Tyr Asp Arg Phe Ala Ala Ile Cys His 
        115                 120                 125             


Pro Leu Asn Tyr Pro Val Ile Met Asn Arg Gly Val Phe Met Lys Leu 
    130                 135                 140                 


Val Ile Phe Ser Trp Ile Ser Gly Ile Met Val Ala Thr Val Gln Thr 
145                 150                 155                 160 


Thr Trp Val Phe Ser Phe Pro Phe Cys Gly Pro Asn Glu Ile Asn His 
                165                 170                 175     


Leu Phe Cys Glu Thr Pro Pro Val Leu Glu Leu Val Cys Ala Asp Thr 
            180                 185                 190         


Phe Leu Phe Glu Ile Tyr Ala Phe Thr Gly Thr Ile Leu Ile Val Met 
        195                 200                 205             


Val Pro Phe Leu Leu Ile Leu Leu Ser Tyr Ile Arg Val Leu Phe Ala 
    210                 215                 220                 


Ile Leu Lys Met Pro Ser Thr Thr Gly Arg Gln Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Ala Ser His Leu Thr Ser Val Thr Leu Phe Tyr Gly Thr Ala Asn 
                245                 250                 255     


Met Thr Tyr Leu Gln Pro Lys Ser Gly Tyr Ser Pro Glu Thr Lys Lys 
            260                 265                 270         


Leu Ile Ser Leu Ala Tyr Thr Leu Leu Thr Pro Leu Leu Asn Pro Leu 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Ser Glu Met Lys Arg Thr Leu Ile Lys Leu 
    290                 295                 300                 


Trp Arg Arg Lys Val Ile Leu His Thr Phe 
305                 310                 


<210>  423
<211>  634
<212>  PRT
<213>  Homo sapiens

<400>  423

Met Ala Pro Lys Lys Lys Ile Val Lys Lys Asn Lys Gly Asp Ile Asn 
1               5                   10                  15      


Glu Met Thr Ile Ile Val Glu Asp Ser Pro Leu Asn Lys Leu Asn Ala 
            20                  25                  30          


Leu Asn Gly Leu Leu Glu Gly Gly Asn Gly Leu Ser Cys Ile Ser Ser 
        35                  40                  45              


Glu Leu Thr Asp Ala Ser Tyr Gly Pro Asn Leu Leu Glu Gly Leu Ser 
    50                  55                  60                  


Lys Met Arg Gln Glu Asn Phe Leu Cys Asp Leu Val Ile Gly Thr Lys 
65                  70                  75                  80  


Thr Lys Ser Phe Asp Val His Lys Ser Val Met Ala Ser Cys Ser Glu 
                85                  90                  95      


Tyr Phe Tyr Asn Ile Leu Lys Lys Asp Pro Ser Ile Gln Arg Val Asp 
            100                 105                 110         


Leu Asn Asp Ile Ser Pro Leu Gly Leu Ala Thr Val Ile Ala Tyr Ala 
        115                 120                 125             


Tyr Thr Gly Lys Leu Thr Leu Ser Leu Tyr Thr Ile Gly Ser Ile Ile 
    130                 135                 140                 


Ser Ala Ala Val Tyr Leu Gln Ile His Thr Leu Val Lys Met Cys Ser 
145                 150                 155                 160 


Asp Phe Leu Ile Arg Glu Met Ser Val Glu Asn Cys Met Tyr Val Val 
                165                 170                 175     


Asn Ile Ala Glu Thr Tyr Ser Leu Lys Asn Ala Lys Ala Ala Ala Gln 
            180                 185                 190         


Lys Phe Ile Arg Asp Asn Phe Leu Glu Phe Ala Glu Ser Asp Gln Phe 
        195                 200                 205             


Met Lys Leu Thr Phe Glu Gln Ile Asn Glu Leu Leu Ile Asp Asp Asp 
    210                 215                 220                 


Leu Gln Leu Pro Ser Glu Ile Val Ala Phe Gln Ile Ala Met Lys Trp 
225                 230                 235                 240 


Leu Glu Phe Asp Gln Lys Arg Val Lys Tyr Ala Ala Asp Leu Leu Ser 
                245                 250                 255     


Asn Ile Arg Phe Gly Thr Ile Ser Ala Gln Asp Leu Val Asn Tyr Val 
            260                 265                 270         


Gln Ser Val Pro Arg Met Met Gln Asp Ala Asp Cys His Arg Leu Leu 
        275                 280                 285             


Val Asp Ala Met Asn Tyr His Leu Leu Pro Tyr His Gln Asn Thr Leu 
    290                 295                 300                 


Gln Ser Arg Arg Thr Arg Ile Arg Gly Gly Cys Arg Val Leu Val Thr 
305                 310                 315                 320 


Val Gly Gly Arg Pro Gly Leu Thr Glu Lys Ser Leu Ser Arg Asp Ile 
                325                 330                 335     


Leu Tyr Arg Asp Pro Glu Asn Gly Trp Ser Lys Leu Thr Glu Met Pro 
            340                 345                 350         


Ala Lys Ser Phe Asn Gln Cys Val Ala Val Met Asp Gly Phe Leu Tyr 
        355                 360                 365             


Val Ala Gly Gly Glu Asp Gln Asn Asp Ala Arg Asn Gln Ala Lys His 
    370                 375                 380                 


Ala Val Ser Asn Phe Cys Arg Tyr Asp Pro Arg Phe Asn Thr Trp Ile 
385                 390                 395                 400 


His Leu Ala Ser Met Asn Gln Lys Arg Thr His Phe Ser Leu Ser Val 
                405                 410                 415     


Phe Asn Gly Leu Val Tyr Ala Ala Gly Gly Arg Asn Ala Glu Gly Ser 
            420                 425                 430         


Leu Ala Ser Leu Glu Cys Tyr Val Pro Ser Thr Asn Gln Trp Gln Pro 
        435                 440                 445             


Lys Thr Pro Leu Glu Val Ala Arg Cys Cys His Ala Ser Ala Val Ala 
    450                 455                 460                 


Asp Gly Arg Val Leu Val Thr Gly Gly Tyr Ile Ala Asn Ala Tyr Ser 
465                 470                 475                 480 


Arg Ser Val Cys Ala Tyr Asp Pro Ala Ser Asp Ser Trp Gln Glu Leu 
                485                 490                 495     


Pro Asn Leu Ser Thr Pro Arg Gly Trp His Cys Ala Val Thr Leu Ser 
            500                 505                 510         


Asp Arg Val Tyr Val Met Gly Gly Ser Gln Leu Gly Pro Arg Gly Glu 
        515                 520                 525             


Arg Val Asp Val Leu Thr Val Glu Cys Tyr Ser Pro Ala Thr Gly Gln 
    530                 535                 540                 


Trp Ser Tyr Ala Ala Pro Leu Gln Val Gly Val Ser Thr Ala Gly Val 
545                 550                 555                 560 


Ser Ala Leu His Gly Arg Ala Tyr Leu Val Gly Gly Trp Asn Glu Gly 
                565                 570                 575     


Glu Lys Lys Tyr Lys Lys Cys Ile Gln Cys Phe Ser Pro Glu Leu Asn 
            580                 585                 590         


Glu Trp Thr Glu Asp Asp Glu Leu Pro Glu Ala Thr Val Gly Val Ser 
        595                 600                 605             


Cys Cys Thr Leu Ser Met Pro Asn Asn Val Thr Arg Glu Ser Arg Ala 
    610                 615                 620                 


Ser Ser Val Ser Ser Val Pro Val Ser Ile 
625                 630                 


<210>  424
<211>  634
<212>  PRT
<213>  Homo sapiens

<400>  424

Met Val Arg Leu Val Leu Pro Asn Pro Gly Leu Asp Ala Arg Ile Pro 
1               5                   10                  15      


Ser Leu Ala Glu Leu Glu Thr Ile Glu Gln Glu Glu Ala Ser Ser Arg 
            20                  25                  30          


Pro Lys Trp Asp Asn Lys Ala Gln Tyr Met Leu Thr Cys Leu Gly Phe 
        35                  40                  45              


Cys Val Gly Leu Gly Asn Val Trp Arg Phe Pro Tyr Leu Cys Gln Ser 
    50                  55                  60                  


His Gly Gly Gly Ala Phe Met Ile Pro Phe Leu Ile Leu Leu Val Leu 
65                  70                  75                  80  


Glu Gly Ile Pro Leu Leu Tyr Leu Glu Phe Ala Ile Gly Gln Arg Leu 
                85                  90                  95      


Arg Arg Gly Ser Leu Gly Val Trp Ser Ser Ile His Pro Ala Leu Lys 
            100                 105                 110         


Gly Leu Gly Leu Ala Ser Met Leu Thr Ser Phe Met Val Gly Leu Tyr 
        115                 120                 125             


Tyr Asn Thr Ile Ile Ser Trp Ile Met Trp Tyr Leu Phe Asn Ser Phe 
    130                 135                 140                 


Gln Glu Pro Leu Pro Trp Ser Asp Cys Pro Leu Asn Glu Asn Gln Thr 
145                 150                 155                 160 


Gly Tyr Val Asp Glu Cys Ala Arg Ser Ser Pro Val Asp Tyr Phe Trp 
                165                 170                 175     


Tyr Arg Glu Thr Leu Asn Ile Ser Thr Ser Ile Ser Asp Ser Gly Ser 
            180                 185                 190         


Ile Gln Trp Trp Met Leu Leu Cys Leu Ala Cys Ala Trp Ser Val Leu 
        195                 200                 205             


Tyr Met Cys Thr Ile Arg Gly Ile Glu Thr Thr Gly Lys Ala Val Tyr 
    210                 215                 220                 


Ile Thr Ser Thr Leu Pro Tyr Val Val Leu Thr Ile Phe Leu Ile Arg 
225                 230                 235                 240 


Gly Leu Thr Leu Lys Gly Ala Thr Asn Gly Ile Val Phe Leu Phe Thr 
                245                 250                 255     


Pro Asn Val Thr Glu Leu Ala Gln Pro Asp Thr Trp Leu Asp Ala Gly 
            260                 265                 270         


Ala Gln Val Phe Phe Ser Phe Ser Leu Ala Phe Gly Gly Leu Ile Ser 
        275                 280                 285             


Phe Ser Ser Tyr Asn Ser Val His Asn Asn Cys Glu Lys Asp Ser Val 
    290                 295                 300                 


Ile Val Ser Ile Ile Asn Gly Phe Thr Ser Val Tyr Val Ala Ile Val 
305                 310                 315                 320 


Val Tyr Ser Val Ile Gly Phe Arg Ala Thr Gln Arg Tyr Asp Asp Cys 
                325                 330                 335     


Phe Ser Thr Asn Ile Leu Thr Leu Ile Asn Gly Phe Asp Leu Pro Glu 
            340                 345                 350         


Gly Asn Val Thr Gln Glu Asn Phe Val Asp Met Gln Gln Arg Cys Asn 
        355                 360                 365             


Ala Ser Asp Pro Ala Ala Tyr Ala Gln Leu Val Phe Gln Thr Cys Asp 
    370                 375                 380                 


Ile Asn Ala Phe Leu Ser Glu Ala Val Glu Gly Thr Gly Leu Ala Phe 
385                 390                 395                 400 


Ile Val Phe Thr Glu Ala Ile Thr Lys Met Pro Leu Ser Pro Leu Trp 
                405                 410                 415     


Ser Val Leu Phe Phe Ile Met Leu Phe Cys Leu Gly Leu Ser Ser Met 
            420                 425                 430         


Phe Gly Asn Met Glu Gly Val Val Val Pro Leu Gln Asp Leu Arg Val 
        435                 440                 445             


Ile Pro Pro Lys Trp Pro Lys Glu Val Leu Thr Gly Leu Ile Cys Leu 
    450                 455                 460                 


Gly Thr Phe Leu Ile Gly Phe Ile Phe Thr Leu Asn Ser Gly Gln Tyr 
465                 470                 475                 480 


Trp Leu Ser Leu Leu Asp Ser Tyr Ala Gly Ser Ile Pro Leu Leu Ile 
                485                 490                 495     


Ile Ala Phe Cys Glu Met Phe Ser Val Val Tyr Val Tyr Gly Val Asp 
            500                 505                 510         


Arg Phe Asn Lys Asp Ile Glu Phe Met Ile Gly His Lys Pro Asn Ile 
        515                 520                 525             


Phe Trp Gln Val Thr Trp Arg Val Val Ser Pro Leu Leu Met Leu Ile 
    530                 535                 540                 


Ile Phe Leu Phe Phe Phe Val Val Glu Val Ser Gln Glu Leu Thr Tyr 
545                 550                 555                 560 


Ser Ile Trp Asp Pro Gly Tyr Glu Glu Phe Pro Lys Ser Gln Lys Ile 
                565                 570                 575     


Ser Tyr Pro Asn Trp Val Tyr Val Val Val Val Ile Val Ala Gly Val 
            580                 585                 590         


Pro Ser Leu Thr Ile Pro Gly Tyr Ala Ile Tyr Lys Leu Ile Arg Asn 
        595                 600                 605             


His Cys Gln Lys Pro Gly Asp His Gln Gly Leu Val Ser Thr Leu Ser 
    610                 615                 620                 


Thr Ala Ser Met Asn Gly Asp Leu Lys Tyr 
625                 630                 


<210>  425
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  425

Met Ala Ser Asp Leu Asp Phe Ser Pro Pro Glu Val Pro Glu Pro Thr 
1               5                   10                  15      


Phe Leu Glu Asn Leu Leu Arg Tyr Gly Leu Phe Leu Gly Ala Ile Phe 
            20                  25                  30          


Gln Leu Ile Cys Val Leu Ala Ile Ile Val Pro Ile Pro Lys Ser His 
        35                  40                  45              


Glu Ala Glu Ala Glu Pro Ser Glu Pro Arg Ser Ala Glu Val Thr Arg 
    50                  55                  60                  


Lys Pro Lys Ala Ala Val Pro Ser Val Asn Lys Arg Pro Lys Lys Glu 
65                  70                  75                  80  


Thr Lys Lys Lys Arg 
                85  


<210>  426
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  426

Met Leu Leu Arg Ser Trp Phe Gly Asn Lys Asp Phe Gln Ala Leu Pro 
1               5                   10                  15      


Ile Leu Ala Arg Leu Pro Ser Met Pro Thr Asp Met Glu His Thr Gly 
            20                  25                  30          


His Tyr Leu His Leu Ala Phe Leu Met Thr Thr Val Phe Ser Leu Ser 
        35                  40                  45              


Pro Gly Thr Lys Ala Asn Tyr Thr Arg Leu Trp Ala Asn Ser Thr Ser 
    50                  55                  60                  


Ser Trp Asp Ser Val Ile Gln Asn Lys Thr Gly Arg Asn Gln Asn Glu 
65                  70                  75                  80  


Asn Ile Asn Thr Asn Pro Ile Thr Pro Glu Val Asp Tyr Lys Gly Asn 
                85                  90                  95      


Ser Thr Asn Met Pro Glu Thr Ser His Ile Val Ala Leu Thr Ser Lys 
            100                 105                 110         


Ser Glu Gln Glu Leu Tyr Ile Pro Ser Val Val Ser Asn Ser Pro Ser 
        115                 120                 125             


Thr Val Gln Ser Ile Glu Asn Thr Ser Lys Ser His Gly Glu Ile Phe 
    130                 135                 140                 


Lys Lys Asp Val Cys Ala Glu Asn Asn Asn Asn Met Ala Met Leu Ile 
145                 150                 155                 160 


Cys Leu Ile Ile Ile Ala Val Leu Phe Leu Ile Cys Thr Phe Leu Phe 
                165                 170                 175     


Leu Ser Thr Val Val Leu Ala Asn Lys Val Ser Ser Leu Arg Arg Ser 
            180                 185                 190         


Lys Gln Val Gly Lys Arg Gln Pro Arg Ser Asn Gly Asp Phe Leu Ala 
        195                 200                 205             


Ser Gly Leu Trp Pro Ala Glu Ser Asp Thr Trp Lys Arg Thr Lys Gln 
    210                 215                 220                 


Leu Thr Gly Pro Asn Leu Val Met Gln Ser Thr Gly Val Leu Thr Ala 
225                 230                 235                 240 


Thr Arg Glu Arg Lys Asp Glu Glu Gly Thr Glu Lys Leu Thr Asn Lys 
                245                 250                 255     


Gln Ile Gly 
            


<210>  427
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  427

Met Arg Arg Cys Asn Ser Gly Ser Gly Pro Pro Pro Ser Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Trp Leu Leu Ala Val Pro Gly Ala Asn Ala Ala Pro Arg 
            20                  25                  30          


Ser Ala Leu Tyr Ser Pro Ser Asp Pro Leu Thr Leu Leu Gln Ala Asp 
        35                  40                  45              


Thr Val Arg Gly Ala Val Leu Gly Ser Arg Ser Ala Trp Ala Val Glu 
    50                  55                  60                  


Phe Phe Ala Ser Trp Cys Gly His Cys Ile Ala Phe Ala Pro Thr Trp 
65                  70                  75                  80  


Lys Ala Leu Ala Glu Asp Val Lys Ala Trp Arg Pro Ala Leu Tyr Leu 
                85                  90                  95      


Ala Ala Leu Asp Cys Ala Glu Glu Thr Asn Ser Ala Val Cys Arg Asp 
            100                 105                 110         


Phe Asn Ile Pro Gly Phe Pro Thr Val Arg Phe Phe Lys Ala Phe Thr 
        115                 120                 125             


Lys Asn Gly Ser Gly Ala Val Phe Pro Val Ala Gly Ala Asp Val Gln 
    130                 135                 140                 


Thr Leu Arg Glu Arg Leu Ile Asp Ala Leu Glu Ser His His Asp Thr 
145                 150                 155                 160 


Trp Pro Pro Ala Cys Pro Pro Leu Glu Pro Ala Lys Leu Glu Glu Ile 
                165                 170                 175     


Asp Gly Phe Phe Ala Arg Asn Asn Glu Glu Tyr Leu Ala Leu Ile Phe 
            180                 185                 190         


Glu Lys Gly Gly Ser Tyr Leu Gly Arg Glu Val Ala Leu Asp Leu Ser 
        195                 200                 205             


Gln His Lys Gly Val Ala Val Arg Arg Val Leu Asn Thr Glu Ala Asn 
    210                 215                 220                 


Val Val Arg Lys Phe Gly Val Thr Asp Phe Pro Ser Cys Tyr Leu Leu 
225                 230                 235                 240 


Phe Arg Asn Gly Ser Val Ser Arg Val Pro Val Leu Met Glu Ser Arg 
                245                 250                 255     


Ser Phe Tyr Thr Ala Tyr Leu Gln Arg Leu Ser Gly Leu Thr Arg Glu 
            260                 265                 270         


Ala Ala Gln Thr Thr Val Ala Pro Thr Thr Ala Asn Lys Ile Ala Pro 
        275                 280                 285             


Thr Val Trp Lys Leu Ala Asp Arg Ser Lys Ile Tyr Met Ala Asp Leu 
    290                 295                 300                 


Glu Ser Ala Leu His Tyr Ile Leu Arg Ile Glu Val Gly Arg Phe Pro 
305                 310                 315                 320 


Val Leu Glu Gly Gln Arg Leu Val Ala Leu Lys Lys Phe Val Ala Val 
                325                 330                 335     


Leu Ala Lys Tyr Phe Pro Gly Arg Pro Leu Val Gln Asn Phe Leu His 
            340                 345                 350         


Ser Val Asn Glu Trp Leu Lys Arg Gln Lys Arg Asn Lys Ile Pro Tyr 
        355                 360                 365             


Ser Phe Phe Lys Thr Ala Leu Asp Asp Arg Lys Glu Gly Ala Val Leu 
    370                 375                 380                 


Ala Lys Lys Val Asn Trp Ile Gly Cys Gln Gly Ser Glu Pro His Phe 
385                 390                 395                 400 


Arg Gly Phe Pro Cys Ser Leu Trp Val Leu Phe His Phe Leu Thr Val 
                405                 410                 415     


Gln Ala Ala Arg Gln Asn Val Asp His Ser Gln Glu Ala Ala Lys Ala 
            420                 425                 430         


Lys Glu Val Leu Pro Ala Ile Arg Gly Tyr Val His Tyr Phe Phe Gly 
        435                 440                 445             


Cys Arg Asp Cys Ala Ser His Phe Glu Gln Met Ala Ala Ala Ser Met 
    450                 455                 460                 


His Arg Val Gly Ser Pro Asn Ala Ala Val Leu Trp Leu Trp Ser Ser 
465                 470                 475                 480 


His Asn Arg Val Asn Ala Arg Leu Ala Gly Ala Pro Ser Glu Asp Pro 
                485                 490                 495     


Gln Phe Pro Lys Val Gln Trp Pro Pro Arg Glu Leu Cys Ser Ala Cys 
            500                 505                 510         


His Asn Glu Arg Leu Asp Val Pro Val Trp Asp Val Glu Ala Thr Leu 
        515                 520                 525             


Asn Phe Leu Lys Ala His Phe Ser Pro Ser Asn Ile Ile Leu Asp Phe 
    530                 535                 540                 


Pro Ala Ala Gly Ser Ala Ala Arg Arg Asp Val Gln Asn Val Ala Ala 
545                 550                 555                 560 


Ala Pro Glu Leu Ala Met Gly Ala Leu Glu Leu Glu Ser Arg Asn Ser 
                565                 570                 575     


Thr Leu Asp Pro Gly Lys Pro Glu Met Met Lys Ser Pro Thr Asn Thr 
            580                 585                 590         


Thr Pro His Val Pro Ala Glu Gly Pro Glu Leu Ile 
        595                 600                 


<210>  428
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  428

Met Glu Arg Leu Thr Leu Thr Arg Thr Ile Gly Gly Pro Leu Leu Thr 
1               5                   10                  15      


Ala Thr Leu Leu Gly Lys Thr Thr Ile Asn Asp Tyr Gln Val Ile Arg 
            20                  25                  30          


Met Pro Phe Ser His Leu Ser Thr Tyr Ser Leu Val Trp Val Met Ala 
        35                  40                  45              


Ala Val Val Leu Cys Thr Ala Gln Val Gln Val Val Thr Gln Asp Glu 
    50                  55                  60                  


Arg Glu Gln Leu Tyr Thr Pro Ala Ser Leu Lys Cys Ser Leu Gln Asn 
65                  70                  75                  80  


Ala Gln Glu Ala Leu Ile Val Thr Trp Gln Lys Lys Lys Ala Val Ser 
                85                  90                  95      


Pro Glu Asn Met Val Thr Phe Ser Glu Asn His Gly Val Val Ile Gln 
            100                 105                 110         


Pro Ala Tyr Lys Asp Lys Ile Asn Ile Thr Gln Leu Gly Leu Gln Asn 
        115                 120                 125             


Ser Thr Ile Thr Phe Trp Asn Ile Thr Leu Glu Asp Glu Gly Cys Tyr 
    130                 135                 140                 


Met Cys Leu Phe Asn Thr Phe Gly Phe Gly Lys Ile Ser Gly Thr Ala 
145                 150                 155                 160 


Cys Leu Thr Val Tyr Val Gln Pro Ile Val Ser Leu His Tyr Lys Phe 
                165                 170                 175     


Ser Glu Asp His Leu Asn Ile Thr Cys Ser Ala Thr Ala Arg Pro Ala 
            180                 185                 190         


Pro Met Val Phe Trp Lys Val Pro Arg Ser Gly Ile Glu Asn Ser Thr 
        195                 200                 205             


Val Thr Leu Ser His Pro Asn Gly Thr Thr Ser Val Thr Ser Ile Leu 
    210                 215                 220                 


His Ile Lys Asp Pro Lys Asn Gln Val Gly Lys Glu Val Ile Cys Gln 
225                 230                 235                 240 


Val Leu His Leu Gly Thr Val Thr Asp Phe Lys Gln Thr Val Asn Lys 
                245                 250                 255     


Gly Tyr Trp Phe Ser Val Pro Leu Leu Leu Ser Ile Val Ser Leu Val 
            260                 265                 270         


Ile Leu Leu Val Leu Ile Ser Ile Leu Leu Tyr Trp Lys Arg His Arg 
        275                 280                 285             


Asn Gln Asp Arg Glu Pro 
    290                 


<210>  429
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  429

Met Ala Pro Ala Leu Trp Arg Ala Cys Asn Gly Leu Met Ala Ala Phe 
1               5                   10                  15      


Phe Ala Leu Ala Ala Leu Val Gln Val Asn Asp Pro Asp Ala Glu Val 
            20                  25                  30          


Trp Val Val Val Tyr Thr Ile Pro Ala Val Leu Thr Leu Leu Val Gly 
        35                  40                  45              


Leu Asn Pro Glu Val Thr Gly Asn Val Ile Trp Lys Ser Ile Ser Ala 
    50                  55                  60                  


Ile His Ile Leu Phe Cys Thr Val Trp Ala Val Gly Leu Ala Ser Tyr 
65                  70                  75                  80  


Leu Leu His Arg Thr Gln Gln Asn Ile Leu His Glu Glu Glu Gly Arg 
                85                  90                  95      


Glu Leu Ser Gly Leu Val Ile Ile Thr Ala Trp Ile Ile Leu Cys His 
            100                 105                 110         


Ser Ser Ser Lys Asn Pro Val Gly Gly Arg Ile Gln Leu Ala Ile Ala 
        115                 120                 125             


Ile Val Ile Thr Leu Phe Pro Phe Ile Ser Trp Val Tyr Ile Tyr Ile 
    130                 135                 140                 


Asn Lys Glu Met Arg Ser Ser Trp Pro Thr His Cys Lys Thr Val Ile 
145                 150                 155                 160 


<210>  430
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  430

Met Thr Pro Ser Pro Leu Leu Leu Leu Leu Leu Pro Pro Leu Leu Leu 
1               5                   10                  15      


Gly Ala Phe Pro Pro Ala Ala Ala Ala Arg Gly Pro Pro Lys Met Ala 
            20                  25                  30          


Asp Lys Val Val Pro Arg Gln Val Ala Arg Leu Gly Arg Thr Val Arg 
        35                  40                  45              


Leu Gln Cys Pro Val Glu Gly Asp Pro Pro Pro Leu Thr Met Trp Thr 
    50                  55                  60                  


Lys Asp Gly Arg Thr Ile His Ser Gly Trp Ser Arg Phe Arg Val Leu 
65                  70                  75                  80  


Pro Gln Gly Leu Lys Val Lys Gln Val Glu Arg Glu Asp Ala Gly Val 
                85                  90                  95      


Tyr Val Cys Lys Ala Thr Asn Gly Phe Gly Ser Leu Ser Val Asn Tyr 
            100                 105                 110         


Thr Leu Val Val Leu Asp Asp Ile Ser Pro Gly Lys Glu Ser Leu Gly 
        115                 120                 125             


Pro Asp Ser Ser Ser Gly Gly Gln Glu Asp Pro Ala Ser Gln Gln Trp 
    130                 135                 140                 


Ala Arg Pro Arg Phe Thr Gln Pro Ser Lys Met Arg Arg Arg Val Ile 
145                 150                 155                 160 


Ala Arg Pro Val Gly Ser Ser Val Arg Leu Lys Cys Val Ala Ser Gly 
                165                 170                 175     


His Pro Arg Pro Asp Ile Thr Trp Met Lys Asp Asp Gln Ala Leu Thr 
            180                 185                 190         


Arg Pro Glu Ala Ala Glu Pro Arg Lys Lys Lys Trp Thr Leu Ser Leu 
        195                 200                 205             


Lys Asn Leu Arg Pro Glu Asp Ser Gly Lys Tyr Thr Cys Arg Val Ser 
    210                 215                 220                 


Asn Arg Ala Gly Ala Ile Asn Ala Thr Tyr Lys Val Asp Val Ile Gln 
225                 230                 235                 240 


Arg Thr Arg Ser Lys Pro Val Leu Thr Gly Thr His Pro Val Asn Thr 
                245                 250                 255     


Thr Val Asp Phe Gly Gly Thr Thr Ser Phe Gln Cys Lys Val Arg Ser 
            260                 265                 270         


Asp Val Lys Pro Val Ile Gln Trp Leu Lys Arg Val Glu Tyr Gly Ala 
        275                 280                 285             


Glu Gly Arg His Asn Ser Thr Ile Asp Val Gly Gly Gln Lys Phe Val 
    290                 295                 300                 


Val Leu Pro Thr Gly Asp Val Trp Ser Arg Pro Asp Gly Ser Tyr Leu 
305                 310                 315                 320 


Asn Lys Leu Leu Ile Thr Arg Ala Arg Gln Asp Asp Ala Gly Met Tyr 
                325                 330                 335     


Ile Cys Leu Gly Ala Asn Thr Met Gly Tyr Ser Phe Arg Ser Ala Phe 
            340                 345                 350         


Leu Thr Val Leu Pro Asp Pro Lys Pro Pro Gly Pro Pro Val Ala Ser 
        355                 360                 365             


Ser Ser Ser Ala Thr Ser Leu Pro Trp Pro Val Val Ile Gly Ile Pro 
    370                 375                 380                 


Ala Gly Ala Val Phe Ile Leu Gly Thr Leu Leu Leu Trp Leu Cys Gln 
385                 390                 395                 400 


Ala Gln Lys Lys Pro Cys Thr Pro Ala Pro Ala Pro Pro Leu Pro Gly 
                405                 410                 415     


His Arg Pro Pro Gly Thr Ala Arg Asp Arg Ser Gly Asp Lys Asp Leu 
            420                 425                 430         


Pro Ser Leu Ala Ala Leu Ser Ala Gly Pro Gly Val Gly Leu Cys Glu 
        435                 440                 445             


Glu His Gly Ser Pro Ala Ala Pro Gln His Leu Leu Gly Pro Gly Pro 
    450                 455                 460                 


Val Ala Gly Pro Lys Leu Tyr Pro Lys Leu Tyr Thr Asp Ile His Thr 
465                 470                 475                 480 


His Thr His Thr His Ser His Thr His Ser His Val Glu Gly Lys Val 
                485                 490                 495     


His Gln His Ile His Tyr Gln Cys 
            500                 


<210>  431
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  431

Met Thr Pro Ser Pro Leu Leu Leu Leu Leu Leu Pro Pro Leu Leu Leu 
1               5                   10                  15      


Gly Ala Phe Pro Pro Ala Ala Ala Ala Arg Gly Pro Pro Lys Met Ala 
            20                  25                  30          


Asp Lys Val Val Pro Arg Gln Val Ala Arg Leu Gly Arg Thr Val Arg 
        35                  40                  45              


Leu Gln Cys Pro Val Glu Gly Asp Pro Pro Pro Leu Thr Met Trp Thr 
    50                  55                  60                  


Lys Asp Gly Arg Thr Ile His Ser Gly Trp Ser Arg Phe Arg Val Leu 
65                  70                  75                  80  


Pro Gln Gly Leu Lys Val Lys Gln Val Glu Arg Glu Asp Ala Gly Val 
                85                  90                  95      


Tyr Val Cys Lys Ala Thr Asn Gly Phe Gly Ser Leu Ser Val Asn Tyr 
            100                 105                 110         


Thr Leu Val Val Leu Asp Asp Ile Ser Pro Gly Lys Glu Ser Leu Gly 
        115                 120                 125             


Pro Asp Ser Ser Ser Gly Gly Gln Glu Asp Pro Ala Ser Gln Gln Trp 
    130                 135                 140                 


Ala Arg Pro Arg Phe Thr Gln Pro Ser Lys Met Arg Arg Arg Val Ile 
145                 150                 155                 160 


Ala Arg Pro Val Gly Ser Ser Val Arg Leu Lys Cys Val Ala Ser Gly 
                165                 170                 175     


His Pro Arg Pro Asp Ile Thr Trp Met Lys Asp Asp Gln Ala Leu Thr 
            180                 185                 190         


Arg Pro Glu Ala Ala Glu Pro Arg Lys Lys Lys Trp Thr Leu Ser Leu 
        195                 200                 205             


Lys Asn Leu Arg Pro Glu Asp Ser Gly Lys Tyr Thr Cys Arg Val Ser 
    210                 215                 220                 


Asn Arg Ala Gly Ala Ile Asn Ala Thr Tyr Lys Val Asp Val Ile Gln 
225                 230                 235                 240 


Arg Thr Arg Ser Lys Pro Val Leu Thr Gly Thr His Pro Val Asn Thr 
                245                 250                 255     


Thr Val Asp Phe Gly Gly Thr Thr Ser Phe Gln Cys Lys Val Arg Ser 
            260                 265                 270         


Asp Val Lys Pro Val Ile Gln Trp Leu Lys Arg Val Glu Tyr Gly Ala 
        275                 280                 285             


Glu Gly Arg His Asn Ser Thr Ile Asp Val Gly Gly Gln Lys Phe Val 
    290                 295                 300                 


Val Leu Pro Thr Gly Asp Val Trp Ser Arg Pro Asp Gly Ser Tyr Leu 
305                 310                 315                 320 


Asn Lys Leu Leu Ile Thr Arg Ala Arg Gln Asp Asp Ala Gly Met Tyr 
                325                 330                 335     


Ile Cys Leu Gly Ala Asn Thr Met Gly Tyr Ser Phe Arg Ser Ala Phe 
            340                 345                 350         


Leu Thr Val Leu Pro Asp Pro Lys Pro Pro Gly Pro Pro Val Ala Ser 
        355                 360                 365             


Ser Ser Ser Ala Thr Ser Leu Pro Trp Pro Val Val Ile Gly Ile Pro 
    370                 375                 380                 


Ala Gly Ala Val Phe Ile Leu Gly Thr Leu Leu Leu Trp Leu Cys Gln 
385                 390                 395                 400 


Ala Gln Lys Lys Pro Cys Thr Pro Ala Pro Ala Pro Pro Leu Pro Gly 
                405                 410                 415     


His Arg Pro Pro Gly Thr Ala Arg Asp Arg Ser Gly Asp Lys Asp Leu 
            420                 425                 430         


Pro Ser Leu Ala Ala Leu Ser Ala Gly Pro Gly Val Gly Leu Cys Glu 
        435                 440                 445             


Glu His Gly Ser Pro Ala Ala Pro Gln His Leu Leu Gly Pro Gly Pro 
    450                 455                 460                 


Val Ala Gly Pro Lys Leu Tyr Pro Lys Leu Tyr Thr Asp Ile His Thr 
465                 470                 475                 480 


His Thr His Thr His Ser His Thr His Ser His Val Glu Gly Lys Val 
                485                 490                 495     


His Gln His Ile His Tyr Gln Cys 
            500                 


<210>  432
<211>  789
<212>  PRT
<213>  Homo sapiens

<400>  432

Met Arg Lys Val Glu Ser Arg Gly Glu Gly Gly Arg Glu Glu Leu Gly 
1               5                   10                  15      


Ser Asn Ser Pro Pro Gln Arg Asn Trp Lys Gly Ile Ala Ile Ala Leu 
            20                  25                  30          


Leu Val Ile Leu Val Val Cys Ser Leu Ile Thr Met Ser Val Ile Leu 
        35                  40                  45              


Leu Thr Pro Asp Glu Leu Thr Asn Ser Ser Glu Thr Arg Leu Ser Leu 
    50                  55                  60                  


Glu Asp Leu Phe Arg Lys Asp Phe Val Leu His Asp Pro Glu Ala Arg 
65                  70                  75                  80  


Trp Ile Asn Asp Thr Asp Val Val Tyr Lys Ser Glu Asn Gly His Val 
                85                  90                  95      


Ile Lys Leu Asn Ile Glu Thr Asn Ala Thr Thr Leu Leu Leu Glu Asn 
            100                 105                 110         


Thr Thr Phe Val Thr Phe Lys Ala Ser Arg His Ser Val Ser Pro Asp 
        115                 120                 125             


Leu Lys Tyr Val Leu Leu Ala Tyr Asp Val Lys Gln Ile Phe His Tyr 
    130                 135                 140                 


Ser Tyr Thr Ala Ser Tyr Val Ile Tyr Asn Ile His Thr Arg Glu Val 
145                 150                 155                 160 


Trp Glu Leu Asn Pro Pro Glu Val Glu Asp Ser Val Leu Gln Tyr Ala 
                165                 170                 175     


Ala Trp Gly Val Gln Gly Gln Gln Leu Ile Tyr Ile Phe Glu Asn Asn 
            180                 185                 190         


Ile Tyr Tyr Gln Pro Asp Ile Lys Ser Ser Ser Leu Arg Leu Thr Ser 
        195                 200                 205             


Ser Gly Lys Glu Glu Ile Ile Phe Asn Gly Ile Ala Asp Trp Leu Tyr 
    210                 215                 220                 


Glu Glu Glu Leu Leu His Ser His Ile Ala His Trp Trp Ser Pro Asp 
225                 230                 235                 240 


Gly Glu Arg Leu Ala Phe Leu Met Ile Asn Asp Ser Leu Val Pro Thr 
                245                 250                 255     


Met Val Ile Pro Arg Phe Thr Gly Ala Leu Tyr Pro Lys Gly Lys Gln 
            260                 265                 270         


Tyr Pro Tyr Pro Lys Ala Gly Gln Val Asn Pro Thr Ile Lys Leu Tyr 
        275                 280                 285             


Val Val Asn Leu Tyr Gly Pro Thr His Thr Leu Glu Leu Met Pro Pro 
    290                 295                 300                 


Asp Ser Phe Lys Ser Arg Glu Tyr Tyr Ile Thr Met Val Lys Trp Val 
305                 310                 315                 320 


Ser Asn Thr Lys Thr Val Val Arg Trp Leu Asn Arg Ala Gln Asn Ile 
                325                 330                 335     


Ser Ile Leu Thr Val Cys Glu Thr Thr Thr Gly Ala Cys Ser Lys Lys 
            340                 345                 350         


Tyr Glu Met Thr Ser Asp Thr Trp Leu Ser Gln Gln Asn Glu Glu Pro 
        355                 360                 365             


Val Phe Ser Arg Asp Gly Ser Lys Phe Phe Met Thr Val Pro Val Lys 
    370                 375                 380                 


Gln Gly Gly Arg Gly Glu Phe His His Ile Ala Met Phe Leu Ile Gln 
385                 390                 395                 400 


Ser Lys Ser Glu Gln Ile Thr Val Arg His Leu Thr Ser Gly Asn Trp 
                405                 410                 415     


Glu Val Ile Lys Ile Leu Ala Tyr Asp Glu Thr Thr Gln Lys Ile Tyr 
            420                 425                 430         


Phe Leu Ser Thr Glu Ser Ser Pro Arg Gly Arg Gln Leu Tyr Ser Ala 
        435                 440                 445             


Ser Thr Glu Gly Leu Leu Asn Arg Gln Cys Ile Ser Cys Asn Phe Met 
    450                 455                 460                 


Lys Glu Gln Cys Thr Tyr Phe Asp Ala Ser Phe Ser Pro Met Asn Gln 
465                 470                 475                 480 


His Phe Leu Leu Phe Cys Glu Gly Pro Arg Val Pro Val Val Ser Leu 
                485                 490                 495     


His Ser Thr Asp Asn Pro Ala Lys Tyr Phe Ile Leu Glu Ser Asn Ser 
            500                 505                 510         


Met Leu Lys Glu Ala Ile Leu Lys Lys Lys Ile Gly Lys Pro Glu Ile 
        515                 520                 525             


Lys Ile Leu His Ile Asp Asp Tyr Glu Leu Pro Leu Gln Leu Ser Leu 
    530                 535                 540                 


Pro Lys Asp Phe Met Asp Arg Asn Gln Tyr Ala Leu Leu Leu Ile Met 
545                 550                 555                 560 


Asp Glu Glu Pro Gly Gly Gln Leu Val Thr Asp Lys Phe His Ile Asp 
                565                 570                 575     


Trp Asp Ser Val Leu Ile Asp Met Asp Asn Val Ile Val Ala Arg Phe 
            580                 585                 590         


Asp Gly Arg Gly Ser Gly Phe Gln Gly Leu Lys Ile Leu Gln Glu Ile 
        595                 600                 605             


His Arg Arg Leu Gly Ser Val Glu Val Lys Asp Gln Ile Thr Ala Val 
    610                 615                 620                 


Lys Phe Leu Leu Lys Leu Pro Tyr Ile Asp Ser Lys Arg Leu Ser Ile 
625                 630                 635                 640 


Phe Gly Lys Gly Tyr Gly Gly Tyr Ile Ala Ser Met Ile Leu Lys Ser 
                645                 650                 655     


Asp Glu Lys Leu Phe Lys Cys Gly Ser Val Val Ala Pro Ile Thr Asp 
            660                 665                 670         


Leu Lys Leu Tyr Ala Ser Ala Phe Ser Glu Arg Tyr Leu Gly Met Pro 
        675                 680                 685             


Ser Lys Glu Glu Ser Thr Tyr Gln Ala Ala Ser Val Leu His Asn Val 
    690                 695                 700                 


His Gly Leu Lys Glu Glu Asn Ile Leu Ile Ile His Gly Thr Ala Asp 
705                 710                 715                 720 


Thr Lys Val His Phe Gln His Ser Ala Glu Leu Ile Lys His Leu Ile 
                725                 730                 735     


Lys Ala Gly Val Asn Tyr Thr Met Gln Val Tyr Pro Asp Glu Gly His 
            740                 745                 750         


Asn Val Ser Glu Lys Ser Lys Tyr His Leu Tyr Ser Thr Ile Leu Lys 
        755                 760                 765             


Phe Phe Ser Asp Cys Leu Lys Glu Glu Ile Ser Val Leu Pro Gln Glu 
    770                 775                 780                 


Pro Glu Glu Asp Glu 
785                 


<210>  433
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  433

Met His Asp Ser Asn Asn Val Glu Lys Asp Ile Thr Pro Ser Glu Leu 
1               5                   10                  15      


Pro Ala Asn Pro Gly Cys Leu His Ser Lys Glu His Ser Ile Lys Ala 
            20                  25                  30          


Thr Leu Ile Trp Arg Leu Phe Phe Leu Ile Met Phe Leu Thr Ile Ile 
        35                  40                  45              


Val Cys Gly Met Val Ala Ala Leu Ser Ala Ile Arg Ala Asn Cys His 
    50                  55                  60                  


Gln Glu Pro Ser Val Cys Leu Gln Ala Ala Cys Pro Glu Ser Trp Ile 
65                  70                  75                  80  


Gly Phe Gln Arg Lys Cys Phe Tyr Phe Ser Asp Asp Thr Lys Asn Trp 
                85                  90                  95      


Thr Ser Ser Gln Arg Phe Cys Asp Ser Gln Asp Ala Asp Leu Ala Gln 
            100                 105                 110         


Val Glu Ser Phe Gln Glu Leu Asn Phe Leu Leu Arg Tyr Lys Gly Pro 
        115                 120                 125             


Ser Asp His Trp Ile Gly Leu Ser Arg Glu Gln Gly Gln Pro Trp Lys 
    130                 135                 140                 


Trp Ile Asn Gly Thr Glu Trp Thr Arg Gln Leu Val Met Lys Glu Asp 
145                 150                 155                 160 


Gly Ala Asn Leu Tyr Val Ala Lys Val Ser Gln Val Pro Arg Met Asn 
                165                 170                 175     


Pro Arg Pro Val Met Val Ser Tyr Pro Gly Ser Arg Arg Val Cys Leu 
            180                 185                 190         


Phe Glu 
        


<210>  434
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  434

Met Glu Ala Lys Glu Lys Gln His Leu Leu Asp Ala Arg Pro Ala Ile 
1               5                   10                  15      


Arg Ser Tyr Thr Gly Ser Leu Trp Gln Glu Gly Ala Gly Trp Ile Pro 
            20                  25                  30          


Leu Pro Arg Pro Gly Leu Asp Leu Gln Ala Ile Glu Leu Ala Ala Gln 
        35                  40                  45              


Ser Asn His His Cys His Ala Gln Lys Gly Pro Asp Ser His Cys Asp 
    50                  55                  60                  


Pro Lys Lys Gly Lys Ala Gln Arg Gln Leu Tyr Val Ala Ser Ala Ile 
65                  70                  75                  80  


Cys Leu Leu Phe Met Ile Gly Glu Val Val Gly Gly Tyr Leu Ala His 
                85                  90                  95      


Ser Leu Ala Val Met Thr Asp Ala Ala His Leu Leu Thr Asp Phe Ala 
            100                 105                 110         


Ser Met Leu Ile Ser Leu Phe Ser Leu Trp Met Ser Ser Arg Pro Ala 
        115                 120                 125             


Thr Lys Thr Met Asn Phe Gly Trp Gln Arg Ala Glu Ile Leu Gly Ala 
    130                 135                 140                 


Leu Val Ser Val Leu Ser Ile Trp Val Val Thr Gly Val Leu Val Tyr 
145                 150                 155                 160 


Leu Ala Val Glu Arg Leu Ile Ser Gly Asp Tyr Glu Ile Asp Gly Gly 
                165                 170                 175     


Thr Met Leu Ile Thr Ser Gly Cys Ala Val Ala Val Asn Ile Ile Met 
            180                 185                 190         


Gly Leu Thr Leu His Gln Ser Gly His Gly His Ser His Gly Thr Thr 
        195                 200                 205             


Asn Gln Gln Glu Glu Asn Pro Ser Val Arg Ala Ala Phe Ile His Val 
    210                 215                 220                 


Ile Gly Asp Phe Met Gln Ser Met Gly Val Leu Val Ala Ala Tyr Ile 
225                 230                 235                 240 


Leu Tyr Phe Lys Pro Glu Tyr Lys Tyr Val Asp Pro Ile Cys Thr Phe 
                245                 250                 255     


Val Phe Ser Ile Leu Val Leu Gly Thr Thr Leu Thr Ile Leu Arg Asp 
            260                 265                 270         


Val Ile Leu Val Leu Met Glu Gly Thr Pro Lys Gly Val Asp Phe Thr 
        275                 280                 285             


Ala Val Arg Asp Leu Leu Leu Ser Val Glu Gly Val Glu Ala Leu His 
    290                 295                 300                 


Ser Leu His Ile Trp Ala Leu Thr Val Ala Gln Pro Val Leu Ser Val 
305                 310                 315                 320 


His Ile Ala Ile Ala Gln Asn Thr Asp Ala Gln Ala Val Leu Lys Thr 
                325                 330                 335     


Ala Ser Ser Arg Leu Gln Gly Lys Phe His Phe His Thr Val Thr Ile 
            340                 345                 350         


Gln Ile Glu Asp Tyr Ser Glu Asp Met Lys Asp Cys Gln Ala Cys Gln 
        355                 360                 365             


Gly Pro Ser Asp 
    370         


<210>  435
<211>  1188
<212>  PRT
<213>  Homo sapiens

<400>  435

Met Asp Leu Pro Arg Gly Leu Val Val Ala Trp Ala Leu Ser Leu Trp 
1               5                   10                  15      


Pro Gly Phe Thr Asp Thr Phe Asn Met Asp Thr Arg Lys Pro Arg Val 
            20                  25                  30          


Ile Pro Gly Ser Arg Thr Ala Phe Phe Gly Tyr Thr Val Gln Gln His 
        35                  40                  45              


Asp Ile Ser Gly Asn Lys Trp Leu Val Val Gly Ala Pro Leu Glu Thr 
    50                  55                  60                  


Asn Gly Tyr Gln Lys Thr Gly Asp Val Tyr Lys Cys Pro Val Ile His 
65                  70                  75                  80  


Gly Asn Cys Thr Lys Leu Asn Leu Gly Arg Val Thr Leu Ser Asn Val 
                85                  90                  95      


Ser Glu Arg Lys Asp Asn Met Arg Leu Gly Leu Ser Leu Ala Thr Asn 
            100                 105                 110         


Pro Lys Asp Asn Ser Phe Leu Ala Cys Ser Pro Leu Trp Ser His Glu 
        115                 120                 125             


Cys Gly Ser Ser Tyr Tyr Thr Thr Gly Met Cys Ser Arg Val Asn Ser 
    130                 135                 140                 


Asn Phe Arg Phe Ser Lys Thr Val Ala Pro Ala Leu Gln Arg Cys Gln 
145                 150                 155                 160 


Thr Tyr Met Asp Ile Val Ile Val Leu Asp Gly Ser Asn Ser Ile Tyr 
                165                 170                 175     


Pro Trp Val Glu Val Gln His Phe Leu Ile Asn Ile Leu Lys Lys Phe 
            180                 185                 190         


Tyr Ile Gly Pro Gly Gln Ile Gln Val Gly Val Val Gln Tyr Gly Glu 
        195                 200                 205             


Asp Val Val His Glu Phe His Leu Asn Asp Tyr Arg Ser Val Lys Asp 
    210                 215                 220                 


Val Val Glu Ala Ala Ser His Ile Glu Gln Arg Gly Gly Thr Glu Thr 
225                 230                 235                 240 


Arg Thr Ala Phe Gly Ile Glu Phe Ala Arg Ser Glu Ala Phe Gln Lys 
                245                 250                 255     


Gly Gly Arg Lys Gly Ala Lys Lys Val Met Ile Val Ile Thr Asp Gly 
            260                 265                 270         


Glu Ser His Asp Ser Pro Asp Leu Glu Lys Val Ile Gln Gln Ser Glu 
        275                 280                 285             


Arg Asp Asn Val Thr Arg Tyr Ala Val Ala Val Leu Gly Tyr Tyr Asn 
    290                 295                 300                 


Arg Arg Gly Ile Asn Pro Glu Thr Phe Leu Asn Glu Ile Lys Tyr Ile 
305                 310                 315                 320 


Ala Ser Asp Pro Asp Asp Lys His Phe Phe Asn Val Thr Asp Glu Ala 
                325                 330                 335     


Ala Leu Lys Asp Ile Val Asp Ala Leu Gly Asp Arg Ile Phe Ser Leu 
            340                 345                 350         


Glu Gly Thr Asn Lys Asn Glu Thr Ser Phe Gly Leu Glu Met Ser Gln 
        355                 360                 365             


Thr Gly Phe Ser Ser His Val Val Glu Asp Gly Val Leu Leu Gly Ala 
    370                 375                 380                 


Val Gly Ala Tyr Asp Trp Asn Gly Ala Val Leu Lys Glu Thr Ser Ala 
385                 390                 395                 400 


Gly Lys Val Ile Pro Leu Arg Glu Ser Tyr Leu Lys Glu Phe Pro Glu 
                405                 410                 415     


Glu Leu Lys Asn His Gly Ala Tyr Leu Gly Tyr Thr Val Thr Ser Val 
            420                 425                 430         


Val Ser Ser Arg Gln Gly Arg Val Tyr Val Ala Gly Ala Pro Arg Phe 
        435                 440                 445             


Asn His Thr Gly Lys Val Ile Leu Phe Thr Met His Asn Asn Arg Ser 
    450                 455                 460                 


Leu Thr Ile His Gln Ala Met Arg Gly Gln Gln Ile Gly Ser Tyr Phe 
465                 470                 475                 480 


Gly Ser Glu Ile Thr Ser Val Asp Ile Asp Gly Asp Gly Val Thr Asp 
                485                 490                 495     


Val Leu Leu Val Gly Ala Pro Met Tyr Phe Asn Glu Gly Arg Glu Arg 
            500                 505                 510         


Gly Lys Val Tyr Val Tyr Glu Leu Arg Gln Asn Leu Phe Val Tyr Asn 
        515                 520                 525             


Gly Thr Leu Lys Asp Ser His Ser Tyr Gln Asn Ala Arg Phe Gly Ser 
    530                 535                 540                 


Ser Ile Ala Ser Val Arg Asp Leu Asn Gln Asp Ser Tyr Asn Asp Val 
545                 550                 555                 560 


Val Val Gly Ala Pro Leu Glu Asp Asn His Ala Gly Ala Ile Tyr Ile 
                565                 570                 575     


Phe His Gly Phe Arg Gly Ser Ile Leu Lys Thr Pro Lys Gln Arg Ile 
            580                 585                 590         


Thr Ala Ser Glu Leu Ala Thr Gly Leu Gln Tyr Phe Gly Cys Ser Ile 
        595                 600                 605             


His Gly Gln Leu Asp Leu Asn Glu Asp Gly Leu Ile Asp Leu Ala Val 
    610                 615                 620                 


Gly Ala Leu Gly Asn Ala Val Ile Leu Trp Ser Arg Pro Val Val Gln 
625                 630                 635                 640 


Ile Asn Ala Ser Leu His Phe Glu Pro Ser Lys Ile Asn Ile Phe His 
                645                 650                 655     


Arg Asp Cys Lys Arg Ser Gly Arg Asp Ala Thr Cys Leu Ala Ala Phe 
            660                 665                 670         


Leu Cys Phe Thr Pro Ile Phe Leu Ala Pro His Phe Gln Thr Thr Thr 
        675                 680                 685             


Val Gly Ile Arg Tyr Asn Ala Thr Met Asp Glu Arg Arg Tyr Thr Pro 
    690                 695                 700                 


Arg Ala His Leu Asp Glu Gly Gly Asp Arg Phe Thr Asn Arg Ala Val 
705                 710                 715                 720 


Leu Leu Ser Ser Gly Gln Glu Leu Cys Glu Arg Ile Asn Phe His Val 
                725                 730                 735     


Leu Asp Thr Ala Asp Tyr Val Lys Pro Val Thr Phe Ser Val Glu Tyr 
            740                 745                 750         


Ser Leu Glu Asp Pro Asp His Gly Pro Met Leu Asp Asp Gly Trp Pro 
        755                 760                 765             


Thr Thr Leu Arg Val Ser Val Pro Phe Trp Asn Gly Cys Asn Glu Asp 
    770                 775                 780                 


Glu His Cys Val Pro Asp Leu Val Leu Asp Ala Arg Ser Asp Leu Pro 
785                 790                 795                 800 


Thr Ala Met Glu Tyr Cys Gln Arg Val Leu Arg Lys Pro Ala Gln Asp 
                805                 810                 815     


Cys Ser Ala Tyr Thr Leu Ser Phe Asp Thr Thr Val Phe Ile Ile Glu 
            820                 825                 830         


Ser Thr Arg Gln Arg Val Ala Val Glu Ala Thr Leu Glu Asn Arg Gly 
        835                 840                 845             


Glu Asn Ala Tyr Ser Thr Val Leu Asn Ile Ser Gln Ser Ala Asn Leu 
    850                 855                 860                 


Gln Phe Ala Ser Leu Ile Gln Lys Glu Asp Ser Asp Gly Ser Ile Glu 
865                 870                 875                 880 


Cys Val Asn Glu Glu Arg Arg Leu Gln Lys Gln Val Cys Asn Val Ser 
                885                 890                 895     


Tyr Pro Phe Phe Arg Ala Lys Ala Lys Val Ala Phe Arg Leu Asp Phe 
            900                 905                 910         


Glu Phe Ser Lys Ser Ile Phe Leu His His Leu Glu Ile Glu Leu Ala 
        915                 920                 925             


Ala Gly Ser Asp Ser Asn Glu Arg Asp Ser Thr Lys Glu Asp Asn Val 
    930                 935                 940                 


Ala Pro Leu Arg Phe His Leu Lys Tyr Glu Ala Asp Val Leu Phe Thr 
945                 950                 955                 960 


Arg Ser Ser Ser Leu Ser His Tyr Glu Val Lys Pro Asn Ser Ser Leu 
                965                 970                 975     


Glu Arg Tyr Asp Gly Ile Gly Pro Pro Phe Ser Cys Ile Phe Arg Ile 
            980                 985                 990         


Gln Asn Leu Gly Leu Phe Pro Ile  His Gly Met Met Met  Lys Ile Thr 
        995                 1000                 1005             


Ile Pro  Ile Ala Thr Arg Ser  Gly Asn Arg Leu Leu  Lys Leu Arg 
    1010                 1015                 1020             


Asp Phe  Leu Thr Asp Glu Ala  Asn Thr Ser Cys Asn  Ile Trp Gly 
    1025                 1030                 1035             


Asn Ser  Thr Glu Tyr Arg Pro  Thr Pro Val Glu Glu  Asp Leu Arg 
    1040                 1045                 1050             


Arg Ala  Pro Gln Leu Asn His  Ser Asn Ser Asp Val  Val Ser Ile 
    1055                 1060                 1065             


Asn Cys  Asn Ile Arg Leu Val  Pro Asn Gln Glu Ile  Asn Phe His 
    1070                 1075                 1080             


Leu Leu  Gly Asn Leu Trp Leu  Arg Ser Leu Lys Ala  Leu Lys Tyr 
    1085                 1090                 1095             


Lys Ser  Met Lys Ile Met Val  Asn Ala Ala Leu Gln  Arg Gln Phe 
    1100                 1105                 1110             


His Ser  Pro Phe Ile Phe Arg  Glu Glu Asp Pro Ser  Arg Gln Ile 
    1115                 1120                 1125             


Val Phe  Glu Ile Ser Lys Gln  Glu Asp Trp Gln Val  Pro Ile Trp 
    1130                 1135                 1140             


Ile Ile  Val Gly Ser Thr Leu  Gly Gly Leu Leu Leu  Leu Ala Leu 
    1145                 1150                 1155             


Leu Val  Leu Ala Leu Trp Lys  Leu Gly Phe Phe Arg  Ser Ala Arg 
    1160                 1165                 1170             


Arg Arg  Arg Glu Pro Gly Leu  Asp Pro Thr Pro Lys  Val Leu Glu 
    1175                 1180                 1185             


<210>  436
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  436

Met Lys Arg Glu Asn Gln Ser Ser Val Ser Glu Phe Leu Leu Leu Asp 
1               5                   10                  15      


Leu Pro Ile Trp Pro Glu Gln Gln Ala Val Phe Phe Thr Leu Phe Leu 
            20                  25                  30          


Gly Met Tyr Leu Ile Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Leu 
        35                  40                  45              


Ile Arg Leu Asp Ser His Leu His Thr Pro Met Phe Phe Phe Leu Ser 
    50                  55                  60                  


His Leu Ala Leu Thr Asp Ile Ser Leu Ser Ser Val Thr Val Pro Lys 
65                  70                  75                  80  


Met Leu Leu Ser Met Gln Thr Gln Asp Gln Ser Ile Leu Tyr Ala Gly 
                85                  90                  95      


Cys Val Thr Gln Met Tyr Phe Phe Ile Phe Phe Thr Asp Leu Asp Asn 
            100                 105                 110         


Phe Leu Leu Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 
        115                 120                 125             


Pro Leu Arg Tyr Thr Thr Ile Met Lys Glu Gly Leu Cys Asn Leu Leu 
    130                 135                 140                 


Val Thr Val Ser Trp Ile Leu Ser Cys Thr Asn Ala Leu Ser His Thr 
145                 150                 155                 160 


Leu Leu Leu Ala Gln Leu Ser Phe Cys Ala Asp Asn Thr Ile Pro His 
                165                 170                 175     


Phe Phe Cys Asp Leu Val Ala Leu Leu Lys Leu Ser Cys Ser Asp Ile 
            180                 185                 190         


Ser Leu Asn Glu Leu Val Ile Phe Thr Val Gly Gln Ala Val Ile Thr 
        195                 200                 205             


Leu Pro Leu Ile Cys Ile Leu Ile Ser Tyr Gly His Ile Gly Val Thr 
    210                 215                 220                 


Ile Leu Lys Ala Pro Ser Thr Lys Gly Ile Phe Lys Ala Leu Ser Thr 
225                 230                 235                 240 


Cys Gly Ser His Leu Ser Val Val Ser Leu Tyr Tyr Gly Thr Ile Ile 
                245                 250                 255     


Gly Leu Tyr Phe Leu Pro Ser Ser Ser Ala Ser Ser Asp Lys Asp Val 
            260                 265                 270         


Ile Ala Ser Val Met Tyr Thr Val Ile Thr Pro Leu Leu Asn Pro Phe 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Gly Ala Leu Glu Arg Leu 
    290                 295                 300                 


Phe Asn Arg Ala Thr Val Leu Ser Gln 
305                 310             


<210>  437
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  437

Met Glu Ile Asp Asn Gln Thr Trp Val Arg Glu Phe Ile Leu Leu Gly 
1               5                   10                  15      


Leu Ser Ser Asp Trp Cys Thr Gln Ile Ser Leu Phe Ser Leu Phe Leu 
            20                  25                  30          


Val Thr Tyr Leu Met Thr Val Leu Gly Asn Cys Leu Ile Val Leu Leu 
        35                  40                  45              


Ile Arg Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Thr 
    50                  55                  60                  


Asn Leu Ser Leu Val Asp Val Ser Tyr Ala Thr Ser Val Val Pro Gln 
65                  70                  75                  80  


Leu Leu Ala His Phe Leu Ala Glu His Lys Ala Ile Pro Phe Gln Ser 
                85                  90                  95      


Cys Ala Ala Gln Leu Phe Phe Ser Leu Ala Leu Gly Gly Ile Glu Phe 
            100                 105                 110         


Val Leu Leu Ala Val Met Ala Tyr Asp Arg His Val Ala Val Ser Asp 
        115                 120                 125             


Arg Leu Arg Tyr Ser Ala Ile Met His Gly Gly Leu Cys Ala Arg Leu 
    130                 135                 140                 


Ala Ile Thr Ser Trp Val Ser Gly Ser Ile Asn Ser Leu Val Gln Thr 
145                 150                 155                 160 


Ala Ile Thr Phe Gln Leu Pro Met Cys Thr Asn Lys Phe Ile Asp His 
                165                 170                 175     


Ile Ser Cys Glu Leu Leu Ala Val Val Arg Leu Ala Cys Val Asp Thr 
            180                 185                 190         


Ser Ser Asn Glu Ala Ala Ile Met Val Ser Ser Ile Val Leu Leu Met 
        195                 200                 205             


Thr Pro Phe Cys Leu Val Leu Leu Ser Tyr Ile Arg Ile Ile Ser Thr 
    210                 215                 220                 


Ile Leu Lys Ile Gln Ser Arg Glu Gly Arg Lys Lys Ala Phe His Thr 
225                 230                 235                 240 


Cys Ala Ser His Leu Thr Val Val Ala Leu Cys Tyr Gly Thr Thr Ile 
                245                 250                 255     


Phe Thr Tyr Ile Gln Pro His Ser Gly Pro Ser Val Leu Gln Glu Lys 
            260                 265                 270         


Leu Ile Ser Val Phe Tyr Ala Ile Val Met Pro Leu Leu Asn Pro Val 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Gly Ala Trp His Lys Leu 
    290                 295                 300                 


Leu Glu Lys Phe Ser Gly Leu Thr Ser Lys Leu Gly Thr 
305                 310                 315         


<210>  438
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  438

Met Glu Asn Tyr Asn Gln Thr Ser Thr Asp Phe Ile Leu Leu Gly Leu 
1               5                   10                  15      


Phe Pro Gln Ser Arg Ile Gly Leu Phe Val Phe Thr Leu Ile Phe Leu 
            20                  25                  30          


Ile Phe Leu Met Ala Leu Ile Gly Asn Leu Ser Met Ile Leu Leu Ile 
        35                  40                  45              


Phe Leu Asp Ile His Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln 
    50                  55                  60                  


Leu Ser Leu Ile Asp Leu Asn Tyr Ile Ser Thr Ile Val Pro Lys Met 
65                  70                  75                  80  


Val Tyr Asp Phe Leu Tyr Gly Asn Lys Ser Ile Ser Phe Thr Gly Cys 
                85                  90                  95      


Gly Ile Gln Ser Phe Phe Phe Leu Thr Leu Ala Val Ala Glu Gly Leu 
            100                 105                 110         


Leu Leu Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Phe Pro 
        115                 120                 125             


Leu His Tyr Pro Ile Arg Ile Ser Lys Arg Val Cys Val Met Met Ile 
    130                 135                 140                 


Thr Gly Ser Trp Met Ile Ser Ser Ile Asn Ser Cys Ala His Thr Val 
145                 150                 155                 160 


Tyr Ala Leu Cys Ile Pro Tyr Cys Lys Ser Arg Ala Ile Asn His Phe 
                165                 170                 175     


Phe Cys Asp Val Pro Ala Met Leu Thr Leu Ala Cys Thr Asp Thr Trp 
            180                 185                 190         


Val Tyr Glu Ser Thr Val Phe Leu Ser Ser Thr Ile Phe Leu Val Leu 
        195                 200                 205             


Pro Phe Thr Gly Ile Ala Cys Ser Tyr Gly Arg Val Leu Leu Ala Val 
    210                 215                 220                 


Tyr Arg Met His Ser Ala Glu Gly Arg Lys Lys Ala Tyr Ser Thr Cys 
225                 230                 235                 240 


Ser Thr His Leu Thr Val Val Ser Phe Tyr Tyr Ala Pro Phe Ala Tyr 
                245                 250                 255     


Thr Tyr Val Arg Pro Arg Ser Leu Arg Ser Pro Thr Glu Asp Lys Ile 
            260                 265                 270         


Leu Ala Val Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Ile Ile 
        275                 280                 285             


Tyr Ser Leu Arg Asn Lys Glu Val Met Gly Ala Leu Thr Gln Val Ile 
    290                 295                 300                 


Gln Lys Ile Phe Ser Val Lys Met 
305                 310         


<210>  439
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  439

Met Glu Pro Glu Lys Gln Thr Glu Ile Ser Glu Phe Phe Leu Gln Gly 
1               5                   10                  15      


Leu Ser Glu Lys Pro Glu His Gln Thr Leu Leu Phe Thr Met Phe Leu 
            20                  25                  30          


Ser Thr Tyr Leu Val Thr Ile Ile Gly Asn Ala Leu Ile Ile Leu Ala 
        35                  40                  45              


Ile Ile Thr Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Phe 
    50                  55                  60                  


Asn Leu Ser Leu Val Asp Thr Leu Leu Ser Ser Thr Thr Val Pro Lys 
65                  70                  75                  80  


Met Leu Ala Asn Ile Gln Ala Gln Ser Arg Ala Ile Pro Phe Val Gly 
                85                  90                  95      


Cys Leu Thr Gln Met Tyr Ala Phe His Leu Phe Gly Thr Met Asp Ser 
            100                 105                 110         


Phe Leu Leu Ala Val Met Ala Ile Asp Arg Phe Val Ala Ile Val His 
        115                 120                 125             


Pro Gln Arg Tyr Leu Val Leu Met Cys Ser Pro Val Cys Gly Leu Leu 
    130                 135                 140                 


Leu Gly Ala Ser Trp Met Ile Thr Asn Leu Gln Ser Leu Ile His Thr 
145                 150                 155                 160 


Cys Leu Met Ala Gln Leu Thr Phe Cys Ala Gly Ser Glu Ile Ser His 
                165                 170                 175     


Phe Phe Cys Asp Leu Met Pro Leu Leu Lys Leu Ser Gly Ser Asp Thr 
            180                 185                 190         


His Thr Asn Glu Leu Val Ile Phe Ala Phe Gly Ile Val Val Gly Thr 
        195                 200                 205             


Ser Pro Phe Ser Cys Ile Leu Leu Ser Tyr Ile Arg Ile Phe Trp Thr 
    210                 215                 220                 


Val Phe Lys Ile Pro Ser Thr Arg Gly Lys Trp Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Gly Leu His Leu Thr Val Val Ser Leu Ser Tyr Gly Thr Ile Phe 
                245                 250                 255     


Ala Val Tyr Leu Gln Pro Thr Ser Pro Ser Ser Ser Gln Lys Asp Lys 
            260                 265                 270         


Ala Ala Ala Leu Met Cys Gly Val Phe Ile Pro Met Leu Asn Pro Phe 
        275                 280                 285             


Ile Tyr Ser Ile Arg Asn Lys Asp Met Lys Ala Ala Leu Gly Lys Leu 
    290                 295                 300                 


Ile Gly Lys Val Ala Val Pro Cys Pro Arg Pro Glu Gln Leu Leu Asp 
305                 310                 315                 320 


Val Tyr His Val Pro Gly Ser Leu Leu Ala Ala Arg Asp Thr Glu Met 
                325                 330                 335     


His Pro Ile Pro Tyr Pro Gly Gly Val Gln Ser Leu Ala Gly Asn Arg 
            340                 345                 350         


Asp Met Glu 
        355 


<210>  440
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  440

Met Ala Glu Glu Asn His Thr Met Lys Asn Glu Phe Ile Leu Thr Gly 
1               5                   10                  15      


Phe Thr Asp His Pro Glu Leu Lys Thr Leu Leu Phe Val Val Phe Phe 
            20                  25                  30          


Ala Ile Tyr Leu Ile Thr Val Val Gly Asn Ile Ser Leu Val Ala Leu 
        35                  40                  45              


Ile Phe Thr His Arg Arg Leu His Thr Pro Met Tyr Ile Phe Leu Gly 
    50                  55                  60                  


Asn Leu Ala Leu Val Asp Ser Cys Cys Ala Cys Ala Ile Thr Pro Lys 
65                  70                  75                  80  


Met Leu Glu Asn Phe Phe Ser Glu Asn Lys Arg Ile Ser Leu Tyr Glu 
                85                  90                  95      


Cys Ala Val Gln Phe Tyr Phe Leu Cys Thr Val Glu Thr Ala Asp Cys 
            100                 105                 110         


Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 
        115                 120                 125             


Pro Leu Gln Tyr His Ile Met Met Ser Lys Lys Leu Cys Ile Gln Met 
    130                 135                 140                 


Thr Thr Gly Ala Phe Ile Ala Gly Asn Leu His Ser Met Ile His Val 
145                 150                 155                 160 


Gly Leu Val Phe Arg Leu Val Phe Cys Gly Ser Asn His Ile Asn His 
                165                 170                 175     


Phe Tyr Cys Asp Ile Leu Pro Leu Tyr Arg Leu Ser Cys Val Asp Pro 
            180                 185                 190         


Tyr Ile Asn Glu Leu Val Leu Phe Ile Phe Ser Gly Ser Val Gln Val 
        195                 200                 205             


Phe Thr Ile Gly Ser Val Leu Ile Ser Tyr Leu Tyr Ile Leu Leu Thr 
    210                 215                 220                 


Ile Phe Lys Met Lys Ser Lys Glu Gly Arg Ala Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Ala Ser His Phe Leu Ser Val Ser Leu Phe Tyr Gly Ser Leu Phe 
                245                 250                 255     


Phe Met Tyr Val Arg Pro Asn Leu Leu Glu Glu Gly Asp Lys Asp Ile 
            260                 265                 270         


Pro Ala Ala Ile Leu Phe Thr Ile Val Val Pro Leu Leu Asn Pro Phe 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Arg Glu Val Ile Ser Val Leu Arg Lys Ile 
    290                 295                 300                 


Leu Met Lys Lys 
305             


<210>  441
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  441

Met Gly Leu Asn Lys Ser Ala Ser Thr Phe Gln Leu Thr Gly Phe Pro 
1               5                   10                  15      


Gly Met Glu Lys Ala His His Trp Ile Phe Ile Pro Leu Leu Ala Ala 
            20                  25                  30          


Tyr Ile Ser Ile Leu Leu Gly Asn Gly Thr Leu Leu Phe Leu Ile Arg 
        35                  40                  45              


Asn Asp His Asn Leu His Glu Pro Met Tyr Tyr Phe Leu Ala Met Leu 
    50                  55                  60                  


Ala Ala Thr Asp Leu Gly Val Thr Leu Thr Thr Met Pro Thr Val Leu 
65                  70                  75                  80  


Gly Val Leu Trp Leu Asp His Arg Glu Ile Gly His Gly Ala Cys Phe 
                85                  90                  95      


Ser Gln Ala Tyr Phe Ile His Thr Leu Ser Val Met Glu Ser Gly Val 
            100                 105                 110         


Leu Leu Ala Met Ala Tyr Asp Cys Phe Ile Thr Ile Arg Ser Pro Leu 
        115                 120                 125             


Arg Tyr Thr Ser Ile Leu Thr Asn Thr Gln Val Met Lys Ile Gly Val 
    130                 135                 140                 


Arg Val Leu Thr Arg Ala Gly Leu Ser Ile Met Pro Ile Val Val Arg 
145                 150                 155                 160 


Leu His Trp Phe Pro Tyr Cys Arg Ser His Val Leu Ser His Ala Phe 
                165                 170                 175     


Cys Leu His Gln Asp Val Ile Lys Leu Ala Cys Ala Asp Ile Thr Phe 
            180                 185                 190         


Asn Arg Leu Tyr Pro Val Val Val Leu Phe Ala Met Val Leu Leu Asp 
        195                 200                 205             


Phe Leu Ile Ile Phe Phe Ser Tyr Ile Leu Ile Leu Lys Thr Val Met 
    210                 215                 220                 


Gly Ile Gly Ser Gly Gly Glu Arg Ala Lys Ala Leu Asn Thr Cys Val 
225                 230                 235                 240 


Ser His Ile Cys Cys Ile Leu Val Phe Tyr Val Thr Val Val Cys Leu 
                245                 250                 255     


Thr Phe Ile His Arg Phe Gly Lys His Val Pro His Val Val His Ile 
            260                 265                 270         


Thr Met Ser Tyr Ile His Phe Leu Phe Pro Pro Phe Met Asn Pro Phe 
        275                 280                 285             


Ile Tyr Ser Ile Lys Thr Lys Gln Ile Gln Ser Gly Ile Leu Arg Leu 
    290                 295                 300                 


Phe Ser Leu Pro His Ser Arg Ala 
305                 310         


<210>  442
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  442

Met Gly Leu Phe Asn Val Thr His Pro Ala Phe Phe Leu Leu Thr Gly 
1               5                   10                  15      


Ile Pro Gly Leu Glu Ser Ser His Ser Trp Leu Ser Gly Pro Leu Cys 
            20                  25                  30          


Val Met Tyr Ala Val Ala Leu Gly Gly Asn Thr Val Ile Leu Gln Ala 
        35                  40                  45              


Val Arg Val Glu Pro Ser Leu His Glu Pro Met Tyr Tyr Phe Leu Ser 
    50                  55                  60                  


Met Leu Ser Phe Ser Asp Val Ala Ile Ser Met Ala Thr Leu Pro Thr 
65                  70                  75                  80  


Val Leu Arg Thr Phe Cys Leu Asn Ala Arg Asn Ile Thr Phe Asp Ala 
                85                  90                  95      


Cys Leu Ile Gln Met Phe Leu Ile His Phe Phe Ser Met Met Glu Ser 
            100                 105                 110         


Gly Ile Leu Leu Ala Met Ser Phe Asp Arg Tyr Val Ala Ile Cys Asp 
        115                 120                 125             


Pro Leu Arg Tyr Ala Thr Val Leu Thr Thr Glu Val Ile Ala Ala Met 
    130                 135                 140                 


Gly Leu Gly Ala Ala Ala Arg Ser Phe Ile Thr Leu Phe Pro Leu Pro 
145                 150                 155                 160 


Phe Leu Ile Lys Arg Leu Pro Ile Cys Arg Ser Asn Val Leu Ser His 
                165                 170                 175     


Ser Tyr Cys Leu His Pro Asp Met Met Arg Leu Ala Cys Ala Asp Ile 
            180                 185                 190         


Ser Ile Asn Ser Ile Tyr Gly Leu Phe Val Leu Val Ser Thr Phe Gly 
        195                 200                 205             


Met Asp Leu Phe Phe Ile Phe Leu Ser Tyr Val Leu Ile Leu Arg Ser 
    210                 215                 220                 


Val Met Ala Thr Ala Ser Arg Glu Glu Arg Leu Lys Ala Leu Asn Thr 
225                 230                 235                 240 


Cys Val Ser His Ile Leu Ala Val Leu Ala Phe Tyr Val Pro Met Ile 
                245                 250                 255     


Gly Val Ser Thr Val His Arg Phe Gly Lys His Val Pro Cys Tyr Ile 
            260                 265                 270         


His Val Leu Met Ser Asn Val Tyr Leu Phe Val Pro Pro Val Leu Asn 
        275                 280                 285             


Pro Leu Ile Tyr Ser Ala Lys Thr Lys Glu Ile Arg Arg Ala Ile Phe 
    290                 295                 300                 


Arg Met Phe His His Ile Lys Ile 
305                 310         


<210>  443
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  443

Met Ser Val Gln Tyr Ser Leu Ser Pro Gln Phe Met Leu Leu Ser Asn 
1               5                   10                  15      


Ile Thr Gln Phe Ser Pro Ile Phe Tyr Leu Thr Ser Phe Pro Gly Leu 
            20                  25                  30          


Glu Gly Ile Lys His Trp Ile Phe Ile Pro Phe Phe Phe Met Tyr Met 
        35                  40                  45              


Val Ala Ile Ser Gly Asn Cys Phe Ile Leu Ile Ile Ile Lys Thr Asn 
    50                  55                  60                  


Pro Arg Leu His Thr Pro Met Tyr Tyr Leu Leu Ser Leu Leu Ala Leu 
65                  70                  75                  80  


Thr Asp Leu Gly Leu Cys Val Ser Thr Leu Pro Thr Thr Met Gly Ile 
                85                  90                  95      


Phe Trp Phe Asn Ser His Ser Ile Tyr Phe Gly Ala Cys Gln Ile Gln 
            100                 105                 110         


Met Phe Cys Ile His Ser Phe Ser Phe Met Glu Ser Ser Val Leu Leu 
        115                 120                 125             


Met Met Ser Phe Asp Arg Leu Val Ala Ile Cys His Pro Leu Arg Tyr 
    130                 135                 140                 


Ser Val Ile Ile Thr Gly Gln Gln Val Val Arg Ala Gly Leu Ile Val 
145                 150                 155                 160 


Ile Phe Arg Gly Pro Val Ala Thr Ile Pro Ile Val Leu Leu Leu Lys 
                165                 170                 175     


Ala Phe Pro Tyr Cys Gly Ser Val Val Leu Ser His Ser Phe Cys Leu 
            180                 185                 190         


His Gln Glu Val Ile Gln Leu Ala Cys Thr Asp Ile Thr Phe Asn Asn 
        195                 200                 205             


Leu Tyr Gly Leu Met Val Val Val Phe Thr Val Met Leu Asp Leu Val 
    210                 215                 220                 


Leu Ile Ala Leu Ser Tyr Gly Leu Ile Leu His Thr Val Ala Gly Leu 
225                 230                 235                 240 


Ala Ser Gln Glu Glu Gln Arg Arg Ala Phe Gln Thr Cys Thr Ala Pro 
                245                 250                 255     


Leu Cys Ala Val Leu Val Phe Phe Val Pro Met Met Gly Leu Ser Leu 
            260                 265                 270         


Val His Arg Phe Gly Lys His Ala Pro Pro Ala Ile His Leu Leu Met 
        275                 280                 285             


Ala Asn Val Tyr Leu Phe Val Pro Pro Met Leu Asn Pro Ile Ile Tyr 
    290                 295                 300                 


Ser Ile Lys Thr Lys Glu Ile His Arg Ala Ile Ile Lys Phe Leu Gly 
305                 310                 315                 320 


Leu Lys Lys Ala Ser Lys 
                325     


<210>  444
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  444

Met Ser Asp Ser Asn Leu Ser Asp Asn His Leu Pro Asp Thr Phe Phe 
1               5                   10                  15      


Leu Thr Gly Ile Pro Gly Leu Glu Ala Ala His Phe Trp Ile Ala Ile 
            20                  25                  30          


Pro Phe Cys Ala Met Tyr Leu Val Ala Leu Val Gly Asn Ala Ala Leu 
        35                  40                  45              


Ile Leu Val Ile Ala Met Asp Asn Ala Leu His Ala Pro Met Tyr Leu 
    50                  55                  60                  


Phe Leu Cys Leu Leu Ser Leu Thr Asp Leu Ala Leu Ser Ser Thr Thr 
65                  70                  75                  80  


Val Pro Lys Met Leu Ala Ile Leu Trp Leu His Ala Gly Glu Ile Ser 
                85                  90                  95      


Phe Gly Gly Cys Leu Ala Gln Met Phe Cys Val His Ser Ile Tyr Ala 
            100                 105                 110         


Leu Glu Ser Ser Ile Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala 
        115                 120                 125             


Ile Cys Asn Pro Leu Arg Tyr Thr Thr Ile Leu Asn His Ala Val Ile 
    130                 135                 140                 


Gly Arg Ile Gly Phe Val Gly Leu Phe Arg Ser Val Ala Ile Val Ser 
145                 150                 155                 160 


Pro Phe Ile Phe Leu Leu Arg Arg Leu Pro Tyr Cys Gly His Arg Val 
                165                 170                 175     


Met Thr His Thr Tyr Cys Glu His Met Gly Ile Ala Arg Leu Ala Cys 
            180                 185                 190         


Ala Asn Ile Thr Val Asn Ile Val Tyr Gly Leu Thr Val Ala Leu Leu 
        195                 200                 205             


Ala Met Gly Leu Asp Ser Ile Leu Ile Ala Ile Ser Tyr Gly Phe Ile 
    210                 215                 220                 


Leu His Ala Val Phe His Leu Pro Ser His Asp Ala Gln His Lys Ala 
225                 230                 235                 240 


Leu Ser Thr Cys Gly Ser His Ile Gly Ile Ile Leu Val Phe Tyr Ile 
                245                 250                 255     


Pro Ala Phe Phe Ser Phe Leu Thr His Arg Phe Gly His His Glu Val 
            260                 265                 270         


Pro Lys His Val His Ile Phe Leu Ala Asn Leu Tyr Val Leu Val Pro 
        275                 280                 285             


Pro Val Leu Asn Pro Ile Leu Tyr Gly Ala Arg Thr Lys Glu Ile Arg 
    290                 295                 300                 


Ser Arg Leu Leu Lys Leu Leu His Leu Gly Lys Thr Ser Ile 
305                 310                 315             


<210>  445
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  445

Met Lys Ser Trp Asn Asn Thr Ile Ile Leu Glu Phe Leu Leu Leu Gly 
1               5                   10                  15      


Ile Ser Glu Glu Pro Glu Leu Gln Ala Phe Leu Phe Gly Leu Phe Leu 
            20                  25                  30          


Ser Met Tyr Leu Val Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Ala 
        35                  40                  45              


Thr Ile Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 
    50                  55                  60                  


Asn Leu Ser Phe Val Asp Ile Cys Phe Val Ser Thr Thr Val Pro Lys 
65                  70                  75                  80  


Met Leu Val Asn Ile Gln Thr His Asn Lys Val Ile Thr Tyr Ala Gly 
                85                  90                  95      


Cys Ile Thr Gln Met Cys Phe Phe Leu Leu Phe Val Gly Leu Asp Asn 
            100                 105                 110         


Phe Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 
        115                 120                 125             


Pro Leu His Tyr Met Val Ile Met Asn Pro Gln Leu Cys Gly Leu Leu 
    130                 135                 140                 


Val Leu Ala Ser Trp Ile Met Ser Val Leu Asn Ser Met Leu Gln Ser 
145                 150                 155                 160 


Leu Met Val Leu Pro Leu Pro Phe Cys Thr His Met Glu Ile Pro His 
                165                 170                 175     


Phe Phe Cys Glu Ile Asn Gln Val Val His Leu Ala Cys Ser Asp Thr 
            180                 185                 190         


Phe Leu Asn Asp Ile Val Met Tyr Phe Ala Val Ala Leu Leu Gly Gly 
        195                 200                 205             


Gly Pro Leu Thr Gly Ile Leu Tyr Ser Tyr Ser Lys Ile Val Ser Ser 
    210                 215                 220                 


Ile Arg Ala Ile Ser Ser Ala Gln Gly Lys Tyr Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Cys Leu 
                245                 250                 255     


Gly Val Tyr Leu Ser Ser Ala Ala Thr His Asn Ser His Thr Gly Ala 
            260                 265                 270         


Ala Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys His Ile Lys Gly Ala Met Lys Thr Phe 
    290                 295                 300                 


Phe Arg Gly Lys Gln 
305                 


<210>  446
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  446

Met Ile Ile Tyr Lys Gln Gly Ile Thr Phe Leu Gln Lys Glu Asn Asn 
1               5                   10                  15      


Asn Thr Ile His Leu Asn Thr Met Phe Phe Leu Ser Pro Ala Glu Thr 
            20                  25                  30          


His Gln Arg Met Ala Ala Glu Asn His Ser Phe Val Thr Lys Phe Ile 
        35                  40                  45              


Leu Val Gly Leu Thr Glu Lys Ser Glu Leu Gln Leu Pro Leu Phe Leu 
    50                  55                  60                  


Val Phe Leu Gly Ile Tyr Val Val Thr Val Leu Gly Asn Leu Gly Met 
65                  70                  75                  80  


Ile Thr Leu Ile Gly Leu Ser Ser His Leu His Thr Pro Met Tyr Cys 
                85                  90                  95      


Phe Leu Ser Ser Leu Ser Phe Ile Asp Phe Cys His Ser Thr Val Ile 
            100                 105                 110         


Thr Pro Lys Met Leu Val Asn Phe Val Thr Glu Lys Asn Ile Ile Ser 
        115                 120                 125             


Tyr Pro Glu Cys Met Thr Gln Leu Tyr Phe Phe Leu Val Phe Ala Ile 
    130                 135                 140                 


Ala Glu Cys His Met Leu Ala Ala Met Ala Tyr Asp Gly Tyr Val Ala 
145                 150                 155                 160 


Ile Cys Ser Pro Leu Leu Tyr Ser Ile Ile Ile Ser Asn Lys Ala Cys 
                165                 170                 175     


Phe Ser Leu Ile Leu Val Val Tyr Val Ile Gly Leu Ile Cys Ala Ser 
            180                 185                 190         


Ala His Ile Gly Cys Met Phe Arg Val Gln Phe Cys Lys Phe Asp Val 
        195                 200                 205             


Ile Asn His Tyr Phe Cys Asp Leu Ile Ser Ile Leu Lys Leu Ser Cys 
    210                 215                 220                 


Ser Ser Thr Tyr Ile Asn Glu Leu Leu Ile Leu Ile Phe Ser Gly Ile 
225                 230                 235                 240 


Asn Ile Leu Val Pro Ser Leu Thr Ile Leu Ser Ser Tyr Ile Phe Ile 
                245                 250                 255     


Ile Ala Ser Ile Leu Arg Ile Arg Tyr Thr Glu Gly Arg Ser Lys Ala 
            260                 265                 270         


Phe Ser Thr Cys Ser Ser His Ile Ser Ala Val Ser Val Phe Phe Gly 
        275                 280                 285             


Ser Ala Ala Phe Met Tyr Leu Gln Pro Ser Ser Val Ser Ser Met Asp 
    290                 295                 300                 


Gln Gly Lys Val Ser Ser Val Phe Tyr Thr Ile Val Val Pro Met Leu 
305                 310                 315                 320 


Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val His Val Ala Leu 
                325                 330                 335     


Lys Lys Thr Leu Gly Lys Arg Thr Phe Leu 
            340                 345     


<210>  447
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  447

Met Pro Gly Thr Val Ala Thr Leu Arg Phe Gln Leu Leu Pro Pro Glu 
1               5                   10                  15      


Pro Asp Asp Ala Phe Trp Gly Ala Pro Cys Glu Gln Pro Leu Glu Arg 
            20                  25                  30          


Arg Tyr Gln Ala Leu Pro Ala Leu Val Cys Ile Met Cys Cys Leu Phe 
        35                  40                  45              


Gly Val Val Tyr Cys Phe Phe Gly Tyr Arg Cys Phe Lys Ala Val Leu 
    50                  55                  60                  


Phe Leu Thr Gly Leu Leu Phe Gly Ser Val Val Ile Phe Leu Leu Cys 
65                  70                  75                  80  


Tyr Arg Glu Arg Val Leu Glu Thr Gln Leu Ser Ala Gly Ala Ser Ala 
                85                  90                  95      


Gly Ile Ala Leu Gly Ile Gly Leu Leu Cys Gly Leu Val Ala Met Leu 
            100                 105                 110         


Val Arg Ser Val Gly Leu Phe Leu Val Gly Leu Leu Leu Gly Leu Leu 
        115                 120                 125             


Leu Ala Ala Ala Ala Leu Leu Gly Ser Ala Pro Tyr Tyr Gln Pro Gly 
    130                 135                 140                 


Ser Val Trp Gly Pro Leu Gly Leu Leu Leu Gly Gly Gly Leu Leu Cys 
145                 150                 155                 160 


Ala Leu Leu Thr Leu Arg Trp Pro Arg Pro Leu Thr Thr Leu Ala Thr 
                165                 170                 175     


Ala Val Thr Gly Ala Ala Leu Ile Ala Thr Ala Ala Asp Tyr Phe Ala 
            180                 185                 190         


Glu Leu Leu Leu Leu Gly Arg Tyr Val Val Glu Arg Leu Arg Ala Ala 
        195                 200                 205             


Pro Val Pro Pro Leu Cys Trp Arg Ser Trp Ala Leu Leu Ala Leu Trp 
    210                 215                 220                 


Pro Leu Leu Ser Leu Met Gly Val Leu Val Gln Trp Arg Val Thr Ala 
225                 230                 235                 240 


Glu Gly Asp Ser His Thr Glu Val Val Ile Ser Arg Gln Arg Arg Arg 
                245                 250                 255     


Val Gln Leu Met Arg Ile Arg Gln Gln Glu Asp Arg Lys Glu Lys Arg 
            260                 265                 270         


Arg Lys Lys Arg Pro Pro Arg Ala Pro Leu Arg Gly Pro Arg Ala Pro 
        275                 280                 285             


Pro Arg Pro Gly Pro Pro Asp Pro Ala Tyr Arg Arg Arg Pro Val Pro 
    290                 295                 300                 


Ile Lys Arg Phe Asn Gly Asp Val Leu Ser Pro Ser Tyr Ile Gln Ser 
305                 310                 315                 320 


Phe Arg Asp Arg Gln Thr Gly Ser Ser Leu Ser Ser Phe Met Ala Ser 
                325                 330                 335     


Pro Thr Asp Ala Asp Tyr Glu Tyr Gly Ser Arg Gly Pro Leu Thr Ala 
            340                 345                 350         


Cys Ser Gly Pro Pro Val Arg Val 
        355                 360 


<210>  448
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  448

Met Leu Arg Ser Pro Thr Phe Thr Asp Ala Gly Pro Arg Cys Ser Cys 
1               5                   10                  15      


Leu Pro Val Ser Gln Thr Leu Asp Ser Met Asp Thr Val Leu Met Gly 
            20                  25                  30          


Ser Leu Gln His Cys Cys Cys Leu Leu Pro Lys Met Gly Asp Thr Trp 
        35                  40                  45              


Ala Gln Leu Pro Trp Pro Gly Pro Pro His Pro Ala Met Leu Leu Ile 
    50                  55                  60                  


Ser Leu Leu Leu Ala Ala Gly Leu Met His Ser Asp Ala Gly Thr Ser 
65                  70                  75                  80  


Cys Pro Val Leu Cys Thr Cys Arg Asn Gln Val Val Asp Cys Ser Ser 
                85                  90                  95      


Gln Arg Leu Phe Ser Val Pro Pro Asp Leu Pro Met Asp Thr Arg Asn 
            100                 105                 110         


Leu Ser Leu Ala His Asn Arg Ile Thr Ala Val Pro Pro Gly Tyr Leu 
        115                 120                 125             


Thr Cys Tyr Met Glu Leu Gln Val Leu Asp Leu His Asn Asn Ser Leu 
    130                 135                 140                 


Met Glu Leu Pro Arg Gly Leu Phe Leu His Ala Lys Arg Leu Ala His 
145                 150                 155                 160 


Leu Asp Leu Ser Tyr Asn Asn Phe Ser His Val Pro Ala Asp Met Phe 
                165                 170                 175     


Gln Glu Ala His Gly Leu Val His Ile Asp Leu Ser His Asn Pro Trp 
            180                 185                 190         


Leu Arg Arg Val His Pro Gln Ala Phe Gln Gly Leu Met Gln Leu Arg 
        195                 200                 205             


Asp Leu Asp Leu Ser Tyr Gly Gly Leu Ala Phe Leu Ser Leu Glu Ala 
    210                 215                 220                 


Leu Glu Gly Leu Pro Gly Leu Val Thr Leu Gln Ile Gly Gly Asn Pro 
225                 230                 235                 240 


Trp Val Cys Gly Cys Thr Met Glu Pro Leu Leu Lys Trp Leu Arg Asn 
                245                 250                 255     


Arg Ile Gln Arg Cys Thr Ala Asp Ser Gln Leu Ala Glu Cys Arg Gly 
            260                 265                 270         


Pro Pro Glu Val Glu Gly Ala Pro Leu Phe Ser Leu Thr Glu Glu Ser 
        275                 280                 285             


Phe Lys Ala Cys His Leu Thr Leu Thr Leu Asp Asp Tyr Leu Phe Ile 
    290                 295                 300                 


Ala Phe Val Gly Phe Val Val Ser Ile Ala Ser Val Ala Thr Asn Phe 
305                 310                 315                 320 


Leu Leu Gly Ile Thr Ala Asn Cys Cys His Arg Trp Ser Lys Ala Ser 
                325                 330                 335     


Glu Glu Glu Glu Ile 
            340     


<210>  449
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  449

Met Ser Leu Ala Ser Gly Pro Gly Pro Gly Trp Leu Leu Phe Ser Phe 
1               5                   10                  15      


Gly Met Gly Leu Val Ser Gly Ser Lys Cys Pro Asn Asn Cys Leu Cys 
            20                  25                  30          


Gln Ala Gln Glu Val Ile Cys Thr Gly Lys Gln Leu Thr Glu Tyr Pro 
        35                  40                  45              


Leu Asp Ile Pro Leu Asn Thr Arg Arg Leu Phe Leu Asn Glu Asn Arg 
    50                  55                  60                  


Ile Thr Ser Leu Pro Ala Met His Leu Gly Leu Leu Ser Asp Leu Val 
65                  70                  75                  80  


Tyr Leu Asp Cys Gln Asn Asn Arg Ile Arg Glu Val Met Asp Tyr Thr 
                85                  90                  95      


Phe Ile Gly Val Phe Lys Leu Ile Tyr Leu Asp Leu Ser Ser Asn Asn 
            100                 105                 110         


Leu Thr Ser Ile Ser Pro Phe Thr Phe Ser Val Leu Ser Asn Leu Val 
        115                 120                 125             


Gln Leu Asn Ile Ala Asn Asn Pro His Leu Leu Ser Leu His Lys Phe 
    130                 135                 140                 


Thr Phe Ala Asn Thr Thr Ser Leu Arg Tyr Leu Asp Leu Arg Asn Thr 
145                 150                 155                 160 


Gly Leu Gln Thr Leu Asp Ser Ala Ala Leu Tyr His Leu Thr Thr Leu 
                165                 170                 175     


Glu Thr Leu Phe Leu Ser Gly Asn Pro Trp Lys Cys Asn Cys Ser Phe 
            180                 185                 190         


Leu Asp Phe Ala Ile Phe Leu Ile Val Phe His Met Asp Pro Ser Asp 
        195                 200                 205             


Asp Leu Asn Ala Thr Cys Val Glu Pro Thr Glu Leu Thr Gly Trp Pro 
    210                 215                 220                 


Ile Thr Arg Val Gly Asn Pro Leu Arg Tyr Met Cys Ile Thr His Leu 
225                 230                 235                 240 


Asp His Lys Asp Tyr Ile Phe Leu Leu Leu Ile Gly Phe Cys Ile Phe 
                245                 250                 255     


Ala Ala Gly Thr Val Ala Ala Trp Leu Thr Gly Val Cys Ala Val Leu 
            260                 265                 270         


Tyr Gln Asn Thr Arg His Lys Ser Ser Glu Glu Asp Glu Asp Glu Ala 
        275                 280                 285             


Gly Thr Arg Val Glu Val Ser Arg Arg Ile Phe Gln Thr Gln Thr Ser 
    290                 295                 300                 


Ser Val Gln Glu Phe Pro Gln Leu Ile 
305                 310             


<210>  450
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  450

Met Asn Trp Glu Asn Glu Ser Ser Pro Lys Glu Phe Ile Leu Leu Gly 
1               5                   10                  15      


Phe Ser Asp Arg Ala Trp Leu Gln Met Pro Leu Phe Val Val Leu Leu 
            20                  25                  30          


Ile Ser Tyr Thr Ile Thr Ile Phe Gly Asn Val Ser Ile Met Met Val 
        35                  40                  45              


Cys Ile Leu Asp Pro Lys Leu His Thr Pro Met Tyr Phe Phe Leu Thr 
    50                  55                  60                  


Asn Leu Ser Ile Leu Asp Leu Cys Tyr Thr Thr Thr Thr Val Pro His 
65                  70                  75                  80  


Met Leu Val Asn Ile Gly Cys Asn Lys Lys Thr Ile Ser Tyr Ala Gly 
                85                  90                  95      


Cys Val Ala His Leu Ile Ile Phe Leu Ala Leu Gly Ala Thr Glu Cys 
            100                 105                 110         


Leu Leu Leu Ala Val Met Ser Phe Asp Arg Tyr Val Ala Val Cys Arg 
        115                 120                 125             


Pro Leu His Tyr Val Val Ile Met Asn Tyr Trp Phe Cys Leu Arg Met 
    130                 135                 140                 


Ala Ala Phe Ser Trp Leu Ile Gly Phe Gly Asn Ser Val Leu Gln Ser 
145                 150                 155                 160 


Ser Leu Thr Leu Asn Met Pro Arg Cys Gly His Gln Glu Val Asp His 
                165                 170                 175     


Phe Phe Cys Glu Val Pro Ala Leu Leu Lys Leu Ser Cys Ala Asp Thr 
            180                 185                 190         


Lys Pro Ile Glu Ala Glu Leu Phe Phe Phe Ser Val Leu Ile Leu Leu 
        195                 200                 205             


Ile Pro Val Thr Leu Ile Leu Ile Ser Tyr Gly Phe Ile Ala Gln Ala 
    210                 215                 220                 


Val Leu Lys Ile Arg Ser Ala Glu Gly Arg Gln Lys Ala Phe Gly Thr 
225                 230                 235                 240 


Cys Gly Ser His Met Ile Val Val Ser Leu Phe Tyr Gly Thr Ala Ile 
                245                 250                 255     


Tyr Met Tyr Leu Gln Pro Pro Ser Ser Thr Ser Lys Asp Trp Gly Lys 
            260                 265                 270         


Met Val Ser Leu Phe Tyr Gly Ile Ile Thr Ser Met Leu Asn Ser Leu 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Glu Ala Phe Lys Arg Leu 
    290                 295                 300                 


Met Pro Arg Ile Phe Phe Cys Lys Lys 
305                 310             


<210>  451
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  451

Met Lys Ile Ala Asn Asn Thr Val Val Thr Glu Phe Ile Leu Leu Gly 
1               5                   10                  15      


Leu Thr Gln Ser Gln Asp Ile Gln Leu Leu Val Phe Val Leu Ile Leu 
            20                  25                  30          


Ile Phe Tyr Leu Ile Ile Leu Pro Gly Asn Phe Leu Ile Ile Phe Thr 
        35                  40                  45              


Ile Arg Ser Asp Pro Gly Leu Thr Ala Pro Leu Tyr Leu Phe Leu Gly 
    50                  55                  60                  


Asn Leu Ala Phe Leu Asp Ala Ser Tyr Ser Phe Ile Val Ala Pro Arg 
65                  70                  75                  80  


Met Leu Val Asp Phe Leu Ser Glu Lys Lys Val Ile Ser Tyr Arg Gly 
                85                  90                  95      


Cys Ile Thr Gln Leu Phe Phe Leu His Phe Leu Gly Gly Gly Glu Gly 
            100                 105                 110         


Leu Leu Leu Val Val Met Ala Phe Asp Arg Tyr Ile Ala Ile Cys Arg 
        115                 120                 125             


Pro Leu His Cys Ser Thr Val Met Asn Pro Arg Ala Cys Tyr Ala Met 
    130                 135                 140                 


Met Leu Ala Leu Trp Leu Gly Gly Phe Val His Ser Ile Ile Gln Val 
145                 150                 155                 160 


Val Leu Ile Leu Arg Leu Pro Phe Cys Gly Pro Asn Gln Leu Asp Asn 
                165                 170                 175     


Phe Phe Cys Asp Val Arg Gln Val Ile Lys Leu Ala Cys Thr Asp Met 
            180                 185                 190         


Phe Val Val Glu Leu Leu Met Val Phe Asn Ser Gly Leu Met Thr Leu 
        195                 200                 205             


Leu Cys Phe Leu Gly Leu Leu Ala Ser Tyr Ala Val Ile Leu Cys His 
    210                 215                 220                 


Val Arg Arg Ala Ala Ser Glu Gly Lys Asn Lys Ala Met Ser Thr Cys 
225                 230                 235                 240 


Thr Thr Arg Val Ile Ile Ile Leu Leu Met Phe Gly Pro Ala Ile Phe 
                245                 250                 255     


Ile Tyr Met Cys Pro Phe Arg Ala Leu Pro Ala Asp Lys Met Val Ser 
            260                 265                 270         


Leu Phe His Thr Val Ile Phe Pro Leu Met Asn Pro Met Ile Tyr Thr 
        275                 280                 285             


Leu Arg Asn Gln Glu Val Lys Thr Ser Met Lys Arg Leu Leu Ser Arg 
    290                 295                 300                 


His Val Val Cys Gln Val Asp Phe Ile Ile Arg Asn 
305                 310                 315     


<210>  452
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  452

Met Glu Leu Glu Asn Gln Thr Arg Val Thr Lys Phe Ile Leu Val Gly 
1               5                   10                  15      


Phe Pro Gly Ser Leu Ser Met Arg Ala Ala Met Phe Leu Ile Phe Leu 
            20                  25                  30          


Val Ala Tyr Ile Leu Thr Val Ala Glu Asn Val Ile Ile Ile Leu Leu 
        35                  40                  45              


Val Leu Gln Asn Arg Pro Leu His Lys Pro Met Tyr Phe Phe Leu Ala 
    50                  55                  60                  


Asn Leu Ser Phe Leu Glu Thr Trp Tyr Ile Ser Val Thr Val Pro Lys 
65                  70                  75                  80  


Leu Leu Phe Ser Phe Trp Ser Val Asn Asn Ser Ile Ser Phe Thr Leu 
                85                  90                  95      


Cys Met Ile Gln Leu Tyr Phe Phe Ile Ala Leu Met Cys Thr Glu Cys 
            100                 105                 110         


Val Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Arg 
        115                 120                 125             


Pro Leu His Tyr Pro Thr Ile Met Ser His Gly Leu Cys Phe Arg Leu 
    130                 135                 140                 


Ala Leu Gly Ser Trp Ala Ile Gly Phe Gly Ile Ser Leu Ala Lys Ile 
145                 150                 155                 160 


Tyr Phe Ile Ser Cys Leu Ser Phe Cys Gly Pro Asn Val Ile Asn His 
                165                 170                 175     


Phe Phe Cys Asp Ile Ser Pro Val Leu Asn Leu Ser Cys Thr Asp Met 
            180                 185                 190         


Ser Ile Thr Glu Leu Val Asp Phe Ile Leu Ala Leu Val Ile Phe Leu 
        195                 200                 205             


Phe Pro Leu Phe Ile Thr Val Leu Ser Tyr Gly Cys Ile Leu Ala Thr 
    210                 215                 220                 


Ile Leu Cys Met Pro Thr Gly Lys Gln Lys Ala Phe Ser Thr Cys Ala 
225                 230                 235                 240 


Ser His Leu Val Val Val Thr Ile Phe Tyr Ser Ala Ile Ile Phe Met 
                245                 250                 255     


Tyr Ala Arg Pro Arg Val Ile His Ala Phe Asn Met Asn Lys Ile Ile 
            260                 265                 270         


Ser Ile Phe Tyr Ala Ile Val Thr Pro Ser Leu Asn Pro Phe Ile Tyr 
        275                 280                 285             


Cys Leu Arg Asn Arg Glu Val Lys Glu Ala Leu Lys Lys Leu Ala Tyr 
    290                 295                 300                 


Cys Gln Ala Ser Arg Ser Asp 
305                 310     


<210>  453
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  453

Met Leu Gly Leu Asn Gly Thr Pro Phe Gln Pro Ala Thr Leu Gln Leu 
1               5                   10                  15      


Thr Gly Ile Pro Gly Ile Gln Thr Gly Leu Thr Trp Val Ala Leu Ile 
            20                  25                  30          


Phe Cys Ile Leu Tyr Met Ile Ser Ile Val Gly Asn Leu Ser Ile Leu 
        35                  40                  45              


Thr Leu Val Phe Trp Glu Pro Ala Leu His Gln Pro Met Tyr Tyr Phe 
    50                  55                  60                  


Leu Ser Met Leu Ala Leu Asn Asp Leu Gly Val Ser Phe Ser Thr Leu 
65                  70                  75                  80  


Pro Thr Val Ile Ser Thr Phe Cys Phe Asn Tyr Asn His Val Ala Phe 
                85                  90                  95      


Asn Ala Cys Leu Val Gln Met Phe Phe Ile His Thr Phe Ser Phe Met 
            100                 105                 110         


Glu Ser Gly Ile Leu Leu Ala Met Ser Leu Asp Arg Phe Val Ala Ile 
        115                 120                 125             


Cys Tyr Pro Leu Arg Tyr Val Thr Val Leu Thr His Asn Arg Ile Leu 
    130                 135                 140                 


Ala Met Gly Leu Gly Ile Leu Thr Lys Ser Phe Thr Thr Leu Phe Pro 
145                 150                 155                 160 


Phe Pro Phe Val Val Lys Arg Leu Pro Phe Cys Lys Gly Asn Val Leu 
                165                 170                 175     


His His Ser Tyr Cys Leu His Pro Asp Leu Met Lys Val Ala Cys Gly 
            180                 185                 190         


Asp Ile His Val Asn Asn Ile Tyr Gly Leu Leu Val Ile Ile Phe Thr 
        195                 200                 205             


Tyr Gly Met Asp Ser Thr Phe Ile Leu Leu Ser Tyr Ala Leu Ile Leu 
    210                 215                 220                 


Arg Ala Met Leu Val Ile Ile Ser Gln Glu Gln Arg Leu Lys Ala Leu 
225                 230                 235                 240 


Asn Thr Cys Met Ser His Ile Cys Ala Val Leu Ala Phe Tyr Val Pro 
                245                 250                 255     


Ile Ile Ala Val Ser Met Ile His Arg Phe Trp Lys Ser Ala Pro Pro 
            260                 265                 270         


Val Val His Val Met Met Ser Asn Val Tyr Leu Phe Val Pro Pro Met 
        275                 280                 285             


Leu Asn Pro Ile Ile Tyr Ser Val Lys Thr Lys Glu Ile Arg Lys Gly 
    290                 295                 300                 


Ile Leu Lys Phe Phe His Lys Ser Gln Ala 
305                 310                 


<210>  454
<211>  572
<212>  PRT
<213>  Homo sapiens

<400>  454

Met Glu Cys Leu Tyr Tyr Phe Leu Gly Phe Leu Leu Leu Ala Ala Arg 
1               5                   10                  15      


Leu Pro Leu Asp Ala Ala Lys Arg Phe His Asp Val Leu Gly Asn Glu 
            20                  25                  30          


Arg Pro Ser Ala Tyr Met Arg Glu His Asn Gln Leu Asn Gly Trp Ser 
        35                  40                  45              


Ser Asp Glu Asn Asp Trp Asn Glu Lys Leu Tyr Pro Val Trp Lys Arg 
    50                  55                  60                  


Gly Asp Met Arg Trp Lys Asn Ser Trp Lys Gly Gly Arg Val Gln Ala 
65                  70                  75                  80  


Val Leu Thr Ser Asp Ser Pro Ala Leu Val Gly Ser Asn Ile Thr Phe 
                85                  90                  95      


Ala Val Asn Leu Ile Phe Pro Arg Cys Gln Lys Glu Asp Ala Asn Gly 
            100                 105                 110         


Asn Ile Val Tyr Glu Lys Asn Cys Arg Asn Glu Ala Gly Leu Ser Ala 
        115                 120                 125             


Asp Pro Tyr Val Tyr Asn Trp Thr Ala Trp Ser Glu Asp Ser Asp Gly 
    130                 135                 140                 


Glu Asn Gly Thr Gly Gln Ser His His Asn Val Phe Pro Asp Gly Lys 
145                 150                 155                 160 


Pro Phe Pro His His Pro Gly Trp Arg Arg Trp Asn Phe Ile Tyr Val 
                165                 170                 175     


Phe His Thr Leu Gly Gln Tyr Phe Gln Lys Leu Gly Arg Cys Ser Val 
            180                 185                 190         


Arg Val Ser Val Asn Thr Ala Asn Val Thr Leu Gly Pro Gln Leu Met 
        195                 200                 205             


Glu Val Thr Val Tyr Arg Arg His Gly Arg Ala Tyr Val Pro Ile Ala 
    210                 215                 220                 


Gln Val Lys Asp Val Tyr Val Val Thr Asp Gln Ile Pro Val Phe Val 
225                 230                 235                 240 


Thr Met Phe Gln Lys Asn Asp Arg Asn Ser Ser Asp Glu Thr Phe Leu 
                245                 250                 255     


Lys Asp Leu Pro Ile Met Phe Asp Val Leu Ile His Asp Pro Ser His 
            260                 265                 270         


Phe Leu Asn Tyr Ser Thr Ile Asn Tyr Lys Trp Ser Phe Gly Asp Asn 
        275                 280                 285             


Thr Gly Leu Phe Val Ser Thr Asn His Thr Val Asn His Thr Tyr Val 
    290                 295                 300                 


Leu Asn Gly Thr Phe Ser Leu Asn Leu Thr Val Lys Ala Ala Ala Pro 
305                 310                 315                 320 


Gly Pro Cys Pro Pro Pro Pro Pro Pro Pro Arg Pro Ser Lys Pro Thr 
                325                 330                 335     


Pro Ser Leu Ala Thr Thr Leu Lys Ser Tyr Asp Ser Asn Thr Pro Gly 
            340                 345                 350         


Pro Ala Gly Asp Asn Pro Leu Glu Leu Ser Arg Ile Pro Asp Glu Asn 
        355                 360                 365             


Cys Gln Ile Asn Arg Tyr Gly His Phe Gln Ala Thr Ile Thr Ile Val 
    370                 375                 380                 


Glu Gly Ile Leu Glu Val Asn Ile Ile Gln Met Thr Asp Val Leu Met 
385                 390                 395                 400 


Pro Val Pro Trp Pro Glu Ser Ser Leu Ile Asp Phe Val Val Thr Cys 
                405                 410                 415     


Gln Gly Ser Ile Pro Thr Glu Val Cys Thr Ile Ile Ser Asp Pro Thr 
            420                 425                 430         


Cys Glu Ile Thr Gln Asn Thr Val Cys Ser Pro Val Asp Val Asp Glu 
        435                 440                 445             


Met Cys Leu Leu Thr Val Arg Arg Thr Phe Asn Gly Ser Gly Thr Tyr 
    450                 455                 460                 


Cys Val Asn Leu Thr Leu Gly Asp Asp Thr Ser Leu Ala Leu Thr Ser 
465                 470                 475                 480 


Thr Leu Ile Ser Val Pro Asp Arg Asp Pro Ala Ser Pro Leu Arg Met 
                485                 490                 495     


Ala Asn Ser Ala Leu Ile Ser Val Gly Cys Leu Ala Ile Phe Val Thr 
            500                 505                 510         


Val Ile Ser Leu Leu Val Tyr Lys Lys His Lys Glu Tyr Asn Pro Ile 
        515                 520                 525             


Glu Asn Ser Pro Gly Asn Val Val Arg Ser Lys Gly Leu Ser Val Phe 
    530                 535                 540                 


Leu Asn Arg Ala Lys Ala Val Phe Phe Pro Gly Asn Gln Glu Lys Asp 
545                 550                 555                 560 


Pro Leu Leu Lys Asn Gln Glu Phe Lys Gly Val Ser 
                565                 570         


<210>  455
<211>  460
<212>  PRT
<213>  Homo sapiens

<400>  455

Met Gly Ala Pro Pro Gly Tyr Arg Pro Ser Ala Trp Val His Leu Leu 
1               5                   10                  15      


His Gln Leu Pro Arg Ala Asp Phe Gln Leu Arg Pro Val Pro Ser Val 
            20                  25                  30          


Phe Ala Pro Gln Glu Gln Glu Tyr Gln Gln Ala Leu Leu Leu Val Ala 
        35                  40                  45              


Ala Leu Ala Gly Leu Gly Leu Gly Leu Ser Leu Ile Phe Ile Ala Val 
    50                  55                  60                  


Tyr Leu Ile Arg Phe Cys Cys Cys Arg Pro Pro Glu Pro Pro Gly Ser 
65                  70                  75                  80  


Lys Ile Pro Ser Pro Gly Gly Gly Cys Val Thr Trp Ser Cys Ile Val 
                85                  90                  95      


Ala Leu Leu Ala Gly Cys Thr Gly Ile Gly Ile Gly Phe Tyr Gly Asn 
            100                 105                 110         


Ser Glu Thr Ser Asp Gly Val Ser Gln Leu Ser Ser Ala Leu Leu His 
        115                 120                 125             


Ala Asn His Thr Leu Ser Thr Ile Asp His Leu Val Leu Glu Thr Val 
    130                 135                 140                 


Glu Arg Leu Gly Glu Ala Val Arg Thr Glu Leu Thr Thr Leu Glu Glu 
145                 150                 155                 160 


Val Leu Glu Pro Arg Thr Glu Leu Val Ala Ala Ala Arg Gly Ala Arg 
                165                 170                 175     


Arg Gln Ala Glu Ala Ala Ala Gln Gln Leu Gln Gly Leu Ala Phe Trp 
            180                 185                 190         


Gln Gly Val Pro Leu Ser Pro Leu Gln Val Ala Glu Asn Val Ser Phe 
        195                 200                 205             


Val Glu Glu Tyr Arg Trp Leu Ala Tyr Val Leu Leu Leu Leu Leu Glu 
    210                 215                 220                 


Leu Leu Val Cys Leu Phe Thr Leu Leu Gly Leu Ala Lys Gln Ser Lys 
225                 230                 235                 240 


Trp Leu Val Ile Val Met Thr Val Met Ser Leu Leu Val Leu Val Leu 
                245                 250                 255     


Ser Trp Gly Ser Met Gly Leu Glu Ala Ala Thr Ala Val Gly Leu Ser 
            260                 265                 270         


Asp Phe Cys Ser Asn Pro Asp Pro Tyr Val Leu Asn Leu Thr Gln Glu 
        275                 280                 285             


Glu Thr Gly Leu Ser Ser Asp Ile Leu Ser Tyr Tyr Leu Leu Cys Asn 
    290                 295                 300                 


Arg Ala Val Ser Asn Pro Phe Gln Gln Arg Leu Thr Leu Ser Gln Arg 
305                 310                 315                 320 


Ala Leu Ala Asn Ile His Ser Gln Leu Leu Gly Leu Glu Arg Glu Ala 
                325                 330                 335     


Val Pro Gln Phe Pro Ser Ala Gln Lys Pro Leu Leu Ser Leu Glu Glu 
            340                 345                 350         


Thr Leu Asn Val Thr Glu Gly Asn Phe His Gln Leu Val Ala Leu Leu 
        355                 360                 365             


His Cys Arg Ser Leu His Lys Asp Tyr Gly Ala Ala Leu Arg Gly Leu 
    370                 375                 380                 


Cys Glu Asp Ala Leu Glu Gly Leu Leu Phe Leu Leu Leu Phe Ser Leu 
385                 390                 395                 400 


Leu Ser Ala Gly Ala Leu Ala Thr Ala Leu Cys Ser Leu Pro Arg Ala 
                405                 410                 415     


Trp Ala Leu Phe Pro Pro Arg Asn Pro Ser Ala Leu Cys Ser Gly Ser 
            420                 425                 430         


Arg Leu Ser Glu Pro Leu Leu Pro Ala Gly Leu Glu Pro Gly Ser Pro 
        435                 440                 445             


Leu Arg Ser Phe Pro Gly Cys Arg Arg Arg Pro His 
    450                 455                 460 


<210>  456
<211>  1240
<212>  PRT
<213>  Homo sapiens

<400>  456

Met Ala Arg Gln Pro Pro Pro Pro Trp Val His Ala Ala Phe Leu Leu 
1               5                   10                  15      


Cys Leu Leu Ser Leu Gly Gly Ala Ile Glu Ile Pro Met Asp Pro Ser 
            20                  25                  30          


Ile Gln Asn Glu Leu Thr Gln Pro Pro Thr Ile Thr Lys Gln Ser Ala 
        35                  40                  45              


Lys Asp His Ile Val Asp Pro Arg Asp Asn Ile Leu Ile Glu Cys Glu 
    50                  55                  60                  


Ala Lys Gly Asn Pro Ala Pro Ser Phe His Trp Thr Arg Asn Ser Arg 
65                  70                  75                  80  


Phe Phe Asn Ile Ala Lys Asp Pro Arg Val Ser Met Arg Arg Arg Ser 
                85                  90                  95      


Gly Thr Leu Val Ile Asp Phe Arg Ser Gly Gly Arg Pro Glu Glu Tyr 
            100                 105                 110         


Glu Gly Glu Tyr Gln Cys Phe Ala Arg Asn Lys Phe Gly Thr Ala Leu 
        115                 120                 125             


Ser Asn Arg Ile Arg Leu Gln Val Ser Lys Ser Pro Leu Trp Pro Lys 
    130                 135                 140                 


Glu Asn Leu Asp Pro Val Val Val Gln Glu Gly Ala Pro Leu Thr Leu 
145                 150                 155                 160 


Gln Cys Asn Pro Pro Pro Gly Leu Pro Ser Pro Val Ile Phe Trp Met 
                165                 170                 175     


Ser Ser Ser Met Glu Pro Ile Thr Gln Asp Lys Arg Val Ser Gln Gly 
            180                 185                 190         


His Asn Gly Asp Leu Tyr Phe Ser Asn Val Met Leu Gln Asp Met Gln 
        195                 200                 205             


Thr Asp Tyr Ser Cys Asn Ala Arg Phe His Phe Thr His Thr Ile Gln 
    210                 215                 220                 


Gln Lys Asn Pro Phe Thr Leu Lys Val Leu Thr Thr Arg Gly Val Ala 
225                 230                 235                 240 


Glu Arg Thr Pro Ser Phe Met Tyr Pro Gln Gly Thr Ala Ser Ser Gln 
                245                 250                 255     


Met Val Leu Arg Gly Met Asp Leu Leu Leu Glu Cys Ile Ala Ser Gly 
            260                 265                 270         


Val Pro Thr Pro Asp Ile Ala Trp Tyr Lys Lys Gly Gly Asp Leu Pro 
        275                 280                 285             


Ser Asp Lys Ala Lys Phe Glu Asn Phe Asn Lys Ala Leu Arg Ile Thr 
    290                 295                 300                 


Asn Val Ser Glu Glu Asp Ser Gly Glu Tyr Phe Cys Leu Ala Ser Asn 
305                 310                 315                 320 


Lys Met Gly Ser Ile Arg His Thr Ile Ser Val Arg Val Lys Ala Ala 
                325                 330                 335     


Pro Tyr Trp Leu Asp Glu Pro Lys Asn Leu Ile Leu Ala Pro Gly Glu 
            340                 345                 350         


Asp Gly Arg Leu Val Cys Arg Ala Asn Gly Asn Pro Lys Pro Thr Val 
        355                 360                 365             


Gln Trp Met Val Asn Gly Glu Pro Leu Gln Ser Ala Pro Pro Asn Pro 
    370                 375                 380                 


Asn Arg Glu Val Ala Gly Asp Thr Ile Ile Phe Arg Asp Thr Gln Ile 
385                 390                 395                 400 


Ser Ser Arg Ala Val Tyr Gln Cys Asn Thr Ser Asn Glu His Gly Tyr 
                405                 410                 415     


Leu Leu Ala Asn Ala Phe Val Ser Val Leu Asp Val Pro Pro Arg Met 
            420                 425                 430         


Leu Ser Pro Arg Asn Gln Leu Ile Arg Val Ile Leu Tyr Asn Arg Thr 
        435                 440                 445             


Arg Leu Asp Cys Pro Phe Phe Gly Ser Pro Ile Pro Thr Leu Arg Trp 
    450                 455                 460                 


Phe Lys Asn Gly Gln Gly Ser Asn Leu Asp Gly Gly Asn Tyr His Val 
465                 470                 475                 480 


Tyr Glu Asn Gly Ser Leu Glu Ile Lys Met Ile Arg Lys Glu Asp Gln 
                485                 490                 495     


Gly Ile Tyr Thr Cys Val Ala Thr Asn Ile Leu Gly Lys Ala Glu Asn 
            500                 505                 510         


Gln Val Arg Leu Glu Val Lys Asp Pro Thr Arg Ile Tyr Arg Met Pro 
        515                 520                 525             


Glu Asp Gln Val Ala Arg Arg Gly Thr Thr Val Gln Leu Glu Cys Arg 
    530                 535                 540                 


Val Lys His Asp Pro Ser Leu Lys Leu Thr Val Ser Trp Leu Lys Asp 
545                 550                 555                 560 


Asp Glu Pro Leu Tyr Ile Gly Asn Arg Met Lys Lys Glu Asp Asp Ser 
                565                 570                 575     


Leu Thr Ile Phe Gly Val Ala Glu Arg Asp Gln Gly Ser Tyr Thr Cys 
            580                 585                 590         


Val Ala Ser Thr Glu Leu Asp Gln Asp Leu Ala Lys Ala Tyr Leu Thr 
        595                 600                 605             


Val Leu Ala Asp Gln Ala Thr Pro Thr Asn Arg Leu Ala Ala Leu Pro 
    610                 615                 620                 


Lys Gly Arg Pro Asp Arg Pro Arg Asp Leu Glu Leu Thr Asp Leu Ala 
625                 630                 635                 640 


Glu Arg Ser Val Arg Leu Thr Trp Ile Pro Gly Asp Ala Asn Asn Ser 
                645                 650                 655     


Pro Ile Thr Asp Tyr Val Val Gln Phe Glu Glu Asp Gln Phe Gln Pro 
            660                 665                 670         


Gly Val Trp His Asp His Ser Lys Tyr Pro Gly Ser Val Asn Ser Ala 
        675                 680                 685             


Val Leu Arg Leu Ser Pro Tyr Val Asn Tyr Gln Phe Arg Val Ile Ala 
    690                 695                 700                 


Ile Asn Glu Val Gly Ser Ser His Pro Ser Leu Pro Ser Glu Arg Tyr 
705                 710                 715                 720 


Arg Thr Ser Gly Ala Pro Pro Glu Ser Asn Pro Gly Asp Val Lys Gly 
                725                 730                 735     


Glu Gly Thr Arg Lys Asn Asn Met Glu Ile Thr Trp Thr Pro Met Asn 
            740                 745                 750         


Ala Thr Ser Ala Phe Gly Pro Asn Leu Arg Tyr Ile Val Lys Trp Arg 
        755                 760                 765             


Arg Arg Glu Thr Arg Glu Ala Trp Asn Asn Val Thr Val Trp Gly Ser 
    770                 775                 780                 


Arg Tyr Val Val Gly Gln Thr Pro Val Tyr Val Pro Tyr Glu Ile Arg 
785                 790                 795                 800 


Val Gln Ala Glu Asn Asp Phe Gly Lys Gly Pro Glu Pro Glu Ser Val 
                805                 810                 815     


Ile Gly Tyr Ser Gly Glu Asp Leu Pro Ser Ala Pro Arg Arg Phe Arg 
            820                 825                 830         


Val Arg Gln Pro Asn Leu Glu Thr Ile Asn Leu Glu Trp Asp His Pro 
        835                 840                 845             


Glu His Pro Asn Gly Ile Met Ile Gly Tyr Thr Leu Lys Tyr Val Ala 
    850                 855                 860                 


Phe Asn Gly Thr Lys Val Gly Lys Gln Ile Val Glu Asn Phe Ser Pro 
865                 870                 875                 880 


Asn Gln Thr Lys Phe Thr Val Gln Arg Thr Asp Pro Val Ser Arg Tyr 
                885                 890                 895     


Arg Phe Thr Leu Ser Ala Arg Thr Gln Val Gly Ser Gly Glu Ala Val 
            900                 905                 910         


Thr Glu Glu Ser Pro Ala Pro Pro Asn Glu Ala Thr Pro Thr Ala Ala 
        915                 920                 925             


Pro Pro Thr Leu Pro Pro Thr Thr Val Gly Ala Thr Gly Ala Val Ser 
    930                 935                 940                 


Ser Thr Asp Ala Thr Ala Ile Ala Ala Thr Thr Glu Ala Thr Thr Val 
945                 950                 955                 960 


Pro Ile Ile Pro Thr Val Ala Pro Thr Thr Ile Ala Thr Thr Thr Thr 
                965                 970                 975     


Val Ala Thr Thr Thr Thr Thr Thr Ala Ala Ala Thr Thr Thr Thr Glu 
            980                 985                 990         


Ser Pro Pro Thr Thr Thr Ser Gly  Thr Lys Ile His Glu  Ser Ala Pro 
        995                 1000                 1005             


Asp Glu  Gln Ser Ile Trp Asn  Val Thr Val Leu Pro  Asn Ser Lys 
    1010                 1015                 1020             


Trp Ala  Asn Ile Thr Trp Lys  His Asn Phe Gly Pro  Gly Thr Asp 
    1025                 1030                 1035             


Phe Val  Val Glu Tyr Ile Asp  Ser Asn His Thr Lys  Lys Thr Val 
    1040                 1045                 1050             


Pro Val  Lys Ala Gln Ala Gln  Pro Ile Gln Leu Thr  Asp Leu Tyr 
    1055                 1060                 1065             


Pro Gly  Met Thr Tyr Thr Leu  Arg Val Tyr Ser Arg  Asp Asn Glu 
    1070                 1075                 1080             


Gly Ile  Ser Ser Thr Val Ile  Thr Phe Met Thr Ser  Thr Ala Tyr 
    1085                 1090                 1095             


Thr Asn  Asn Gln Ala Asp Ile  Ala Thr Gln Gly Trp  Phe Ile Gly 
    1100                 1105                 1110             


Leu Met  Cys Ala Ile Ala Leu  Leu Val Leu Ile Leu  Leu Ile Val 
    1115                 1120                 1125             


Cys Phe  Ile Lys Arg Ser Arg  Gly Gly Lys Tyr Pro  Val Arg Glu 
    1130                 1135                 1140             


Lys Lys  Asp Val Pro Leu Gly  Pro Glu Asp Pro Lys  Glu Glu Asp 
    1145                 1150                 1155             


Gly Ser  Phe Asp Tyr Ser Asp  Glu Asp Asn Lys Pro  Leu Gln Gly 
    1160                 1165                 1170             


Ser Gln  Thr Ser Leu Asp Gly  Thr Ile Lys Gln Gln  Glu Ser Asp 
    1175                 1180                 1185             


Asp Ser  Leu Val Asp Tyr Gly  Glu Gly Gly Glu Gly  Gln Phe Asn 
    1190                 1195                 1200             


Glu Asp  Gly Ser Phe Ile Gly  Gln Tyr Thr Val Lys  Lys Asp Lys 
    1205                 1210                 1215             


Glu Glu  Thr Glu Gly Asn Glu  Ser Ser Glu Ala Thr  Ser Pro Val 
    1220                 1225                 1230             


Asn Ala  Ile Tyr Ser Leu Ala  
    1235                 1240 


<210>  457
<211>  619
<212>  PRT
<213>  Homo sapiens

<400>  457

Met Ala Arg Gln Pro Pro Pro Pro Trp Val His Ala Ala Phe Leu Leu 
1               5                   10                  15      


Cys Leu Leu Ser Leu Gly Gly Ala Ile Glu Ile Pro Met Asp Pro Ser 
            20                  25                  30          


Ile Gln Asn Glu Leu Thr Gln Pro Pro Thr Ile Thr Lys Gln Ser Ala 
        35                  40                  45              


Lys Asp His Ile Val Asp Pro Arg Asp Asn Ile Leu Ile Glu Cys Glu 
    50                  55                  60                  


Ala Lys Gly Asn Pro Ala Pro Ser Phe His Trp Thr Arg Asn Ser Arg 
65                  70                  75                  80  


Phe Phe Asn Ile Ala Lys Asp Pro Arg Val Ser Met Arg Arg Arg Ser 
                85                  90                  95      


Gly Thr Leu Val Ile Asp Phe Arg Ser Gly Gly Arg Pro Glu Glu Tyr 
            100                 105                 110         


Glu Gly Glu Tyr Gln Cys Phe Ala Arg Asn Lys Phe Gly Thr Ala Leu 
        115                 120                 125             


Ser Asn Arg Ile Arg Leu Gln Val Ser Lys Ser Pro Leu Trp Pro Lys 
    130                 135                 140                 


Glu Asn Leu Asp Pro Val Val Val Gln Glu Gly Ala Pro Leu Thr Leu 
145                 150                 155                 160 


Gln Cys Asn Pro Pro Pro Gly Leu Pro Ser Pro Val Ile Phe Trp Met 
                165                 170                 175     


Ser Ser Ser Met Glu Pro Ile Thr Gln Asp Lys Arg Val Ser Gln Gly 
            180                 185                 190         


His Asn Gly Asp Leu Tyr Phe Ser Asn Val Met Leu Gln Asp Met Gln 
        195                 200                 205             


Thr Asp Tyr Ser Cys Asn Ala Arg Phe His Phe Thr His Thr Ile Gln 
    210                 215                 220                 


Gln Lys Asn Pro Phe Thr Leu Lys Val Leu Thr Thr Arg Gly Val Ala 
225                 230                 235                 240 


Glu Arg Thr Pro Ser Phe Met Tyr Pro Gln Gly Thr Ala Ser Ser Gln 
                245                 250                 255     


Met Val Leu Arg Gly Met Asp Leu Leu Leu Glu Cys Ile Ala Ser Gly 
            260                 265                 270         


Val Pro Thr Pro Asp Ile Ala Trp Tyr Lys Lys Gly Gly Asp Leu Pro 
        275                 280                 285             


Ser Asp Lys Ala Lys Phe Glu Asn Phe Asn Lys Ala Leu Arg Ile Thr 
    290                 295                 300                 


Asn Val Ser Glu Glu Asp Ser Gly Glu Tyr Phe Cys Leu Ala Ser Asn 
305                 310                 315                 320 


Lys Met Gly Ser Ile Arg His Thr Ile Ser Val Arg Val Lys Ala Ala 
                325                 330                 335     


Pro Tyr Trp Leu Asp Glu Pro Lys Asn Leu Ile Leu Ala Pro Gly Glu 
            340                 345                 350         


Asp Gly Arg Leu Val Cys Arg Ala Asn Gly Asn Pro Lys Pro Thr Val 
        355                 360                 365             


Gln Trp Met Val Asn Gly Glu Pro Leu Gln Ser Ala Pro Pro Asn Pro 
    370                 375                 380                 


Asn Arg Glu Val Ala Gly Asp Thr Ile Ile Phe Arg Asp Thr Gln Ile 
385                 390                 395                 400 


Ser Ser Arg Ala Val Tyr Gln Cys Asn Thr Ser Asn Glu His Gly Tyr 
                405                 410                 415     


Leu Leu Ala Asn Ala Phe Val Ser Val Leu Asp Val Pro Pro Arg Met 
            420                 425                 430         


Leu Ser Pro Arg Asn Gln Leu Ile Arg Val Ile Leu Tyr Asn Arg Thr 
        435                 440                 445             


Arg Leu Asp Cys Pro Phe Phe Gly Ser Pro Ile Pro Thr Leu Arg Trp 
    450                 455                 460                 


Phe Lys Asn Gly Gln Gly Ser Asn Leu Asp Gly Gly Asn Tyr His Val 
465                 470                 475                 480 


Tyr Glu Asn Gly Ser Leu Glu Ile Lys Met Ile Arg Lys Glu Asp Gln 
                485                 490                 495     


Gly Ile Tyr Thr Cys Val Ala Thr Asn Ile Leu Gly Lys Ala Glu Asn 
            500                 505                 510         


Gln Val Arg Leu Glu Val Lys Asp Pro Thr Arg Ile Tyr Arg Met Pro 
        515                 520                 525             


Glu Asp Gln Val Ala Arg Arg Gly Thr Thr Val Gln Leu Glu Cys Arg 
    530                 535                 540                 


Val Lys His Asp Pro Ser Leu Lys Leu Thr Val Ser Trp Leu Lys Asp 
545                 550                 555                 560 


Asp Glu Pro Leu Tyr Ile Gly Asn Arg Met Lys Lys Glu Asp Asp Ser 
                565                 570                 575     


Leu Thr Ile Phe Gly Val Ala Glu Arg Asp Gln Gly Ser Tyr Thr Cys 
            580                 585                 590         


Val Ala Ser Thr Glu Leu Asp Gln Asp Leu Ala Lys Ala Tyr Leu Thr 
        595                 600                 605             


Val Leu Gly Asn Cys Pro Cys Ser Pro Trp His 
    610                 615                 


<210>  458
<211>  2347
<212>  PRT
<213>  Homo sapiens

<400>  458

Met Thr Glu Gly Ala Arg Ala Ala Asp Glu Val Arg Val Pro Leu Gly 
1               5                   10                  15      


Ala Pro Pro Pro Gly Pro Ala Ala Leu Val Gly Ala Ser Pro Glu Ser 
            20                  25                  30          


Pro Gly Ala Pro Gly Arg Glu Ala Glu Arg Gly Ser Glu Leu Gly Val 
        35                  40                  45              


Ser Pro Ser Glu Ser Pro Ala Ala Glu Arg Gly Ala Glu Leu Gly Ala 
    50                  55                  60                  


Asp Glu Glu Gln Arg Val Pro Tyr Pro Ala Leu Ala Ala Thr Val Phe 
65                  70                  75                  80  


Phe Cys Leu Gly Gln Thr Thr Arg Pro Arg Ser Trp Cys Leu Arg Leu 
                85                  90                  95      


Val Cys Asn Pro Trp Phe Glu His Val Ser Met Leu Val Ile Met Leu 
            100                 105                 110         


Asn Cys Val Thr Leu Gly Met Phe Arg Pro Cys Glu Asp Val Glu Cys 
        115                 120                 125             


Gly Ser Glu Arg Cys Asn Ile Leu Glu Ala Phe Asp Ala Phe Ile Phe 
    130                 135                 140                 


Ala Phe Phe Ala Val Glu Met Val Ile Lys Met Val Ala Leu Gly Leu 
145                 150                 155                 160 


Phe Gly Gln Lys Cys Tyr Leu Gly Asp Thr Trp Asn Arg Leu Asp Phe 
                165                 170                 175     


Phe Ile Val Val Ala Gly Met Met Glu Tyr Ser Leu Asp Gly His Asn 
            180                 185                 190         


Val Ser Leu Ser Ala Ile Arg Thr Val Arg Val Leu Arg Pro Leu Arg 
        195                 200                 205             


Ala Ile Asn Arg Val Pro Ser Met Arg Ile Leu Val Thr Leu Leu Leu 
    210                 215                 220                 


Asp Thr Leu Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val 
225                 230                 235                 240 


Phe Phe Ile Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu 
                245                 250                 255     


Arg Asn Arg Cys Phe Leu Asp Ser Ala Phe Val Arg Asn Asn Asn Leu 
            260                 265                 270         


Thr Phe Leu Arg Pro Tyr Tyr Gln Thr Glu Glu Gly Glu Glu Asn Pro 
        275                 280                 285             


Phe Ile Cys Ser Ser Arg Arg Asp Asn Gly Met Gln Lys Cys Ser His 
    290                 295                 300                 


Ile Pro Gly Arg Arg Glu Leu Arg Met Pro Cys Thr Leu Gly Trp Glu 
305                 310                 315                 320 


Ala Tyr Thr Gln Pro Gln Ala Glu Gly Val Gly Ala Ala Arg Asn Ala 
                325                 330                 335     


Cys Ile Asn Trp Asn Gln Tyr Tyr Asn Val Cys Arg Ser Gly Asp Ser 
            340                 345                 350         


Asn Pro His Asn Gly Ala Ile Asn Phe Asp Asn Ile Gly Tyr Ala Trp 
        355                 360                 365             


Ile Ala Ile Phe Gln Val Ile Thr Leu Glu Gly Trp Val Asp Ile Met 
    370                 375                 380                 


Tyr Tyr Val Met Asp Ala His Ser Phe Tyr Asn Phe Ile Tyr Phe Ile 
385                 390                 395                 400 


Leu Leu Ile Ile Val Gly Ser Phe Phe Met Ile Asn Leu Cys Leu Val 
                405                 410                 415     


Val Ile Ala Thr Gln Phe Ser Glu Thr Lys Gln Arg Glu Ser Gln Leu 
            420                 425                 430         


Met Arg Glu Gln Arg Ala Arg His Leu Ser Asn Asp Ser Thr Leu Ala 
        435                 440                 445             


Ser Phe Ser Glu Pro Gly Ser Cys Tyr Glu Glu Leu Leu Lys Tyr Val 
    450                 455                 460                 


Gly His Ile Phe Arg Lys Val Lys Arg Arg Ser Leu Arg Leu Tyr Ala 
465                 470                 475                 480 


Arg Trp Gln Ser Arg Trp Arg Lys Lys Val Asp Pro Ser Ala Val Gln 
                485                 490                 495     


Gly Gln Gly Pro Gly His Arg Gln Arg Arg Ala Gly Arg His Thr Ala 
            500                 505                 510         


Ser Val His His Leu Val Tyr His His His His His His His His His 
        515                 520                 525             


Tyr His Phe Ser His Gly Ser Pro Arg Arg Pro Gly Pro Glu Pro Gly 
    530                 535                 540                 


Ala Cys Asp Thr Arg Leu Val Arg Ala Gly Ala Pro Pro Ser Pro Pro 
545                 550                 555                 560 


Ser Pro Gly Arg Gly Pro Pro Asp Ala Glu Ser Val His Ser Ile Tyr 
                565                 570                 575     


His Ala Asp Cys His Ile Glu Gly Pro Gln Glu Arg Ala Arg Val Ala 
            580                 585                 590         


His Ala Ala Ala Thr Ala Ala Ala Ser Leu Arg Leu Ala Thr Gly Leu 
        595                 600                 605             


Gly Thr Met Asn Tyr Pro Thr Ile Leu Pro Ser Gly Val Gly Ser Gly 
    610                 615                 620                 


Lys Gly Ser Thr Ser Pro Gly Pro Lys Gly Lys Trp Ala Gly Gly Pro 
625                 630                 635                 640 


Pro Gly Thr Gly Gly His Gly Pro Leu Ser Leu Asn Ser Pro Asp Pro 
                645                 650                 655     


Tyr Glu Lys Ile Pro His Val Val Gly Glu His Gly Leu Gly Gln Ala 
            660                 665                 670         


Pro Gly His Leu Ser Gly Leu Ser Val Pro Cys Pro Leu Pro Ser Pro 
        675                 680                 685             


Pro Ala Gly Thr Leu Thr Cys Glu Leu Lys Ser Cys Pro Tyr Cys Thr 
    690                 695                 700                 


Arg Ala Leu Glu Asp Pro Glu Gly Glu Leu Ser Gly Ser Glu Ser Gly 
705                 710                 715                 720 


Asp Ser Asp Gly Arg Gly Val Tyr Glu Phe Thr Gln Asp Val Arg His 
                725                 730                 735     


Gly Asp Arg Trp Asp Pro Thr Arg Pro Pro Arg Ala Thr Asp Thr Pro 
            740                 745                 750         


Gly Pro Gly Pro Gly Ser Pro Gln Arg Arg Ala Gln Gln Arg Ala Ala 
        755                 760                 765             


Pro Gly Glu Pro Gly Trp Met Gly Arg Leu Trp Val Thr Phe Ser Gly 
    770                 775                 780                 


Lys Leu Arg Arg Ile Val Asp Ser Lys Tyr Phe Ser Arg Gly Ile Met 
785                 790                 795                 800 


Met Ala Ile Leu Val Asn Thr Leu Ser Met Gly Val Glu Tyr His Glu 
                805                 810                 815     


Gln Pro Glu Glu Leu Thr Asn Ala Leu Glu Ile Ser Asn Ile Val Phe 
            820                 825                 830         


Thr Ser Met Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Ala Cys Gly 
        835                 840                 845             


Pro Leu Gly Tyr Ile Arg Asn Pro Tyr Asn Ile Phe Asp Gly Ile Ile 
    850                 855                 860                 


Val Val Ile Ser Val Trp Glu Ile Val Gly Gln Ala Asp Gly Gly Leu 
865                 870                 875                 880 


Ser Val Leu Arg Thr Phe Arg Leu Leu Arg Val Leu Lys Leu Val Arg 
                885                 890                 895     


Phe Leu Pro Ala Leu Arg Arg Gln Leu Val Val Leu Val Lys Thr Met 
            900                 905                 910         


Asp Asn Val Ala Thr Phe Cys Thr Leu Leu Met Leu Phe Ile Phe Ile 
        915                 920                 925             


Phe Ser Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ser Leu Lys 
    930                 935                 940                 


Thr Asp Thr Gly Asp Thr Val Pro Asp Arg Lys Asn Phe Asp Ser Leu 
945                 950                 955                 960 


Leu Trp Ala Ile Val Thr Val Phe Gln Ile Leu Thr Gln Glu Asp Trp 
                965                 970                 975     


Asn Val Val Leu Tyr Asn Gly Met Ala Ser Thr Ser Ser Trp Ala Ala 
            980                 985                 990         


Leu Tyr Phe Val Ala Leu Met Thr  Phe Gly Asn Tyr Val  Leu Phe Asn 
        995                 1000                 1005             


Leu Leu  Val Ala Ile Leu Val  Glu Gly Phe Gln Ala  Glu Gly Asp 
    1010                 1015                 1020             


Ala Asn  Arg Ser Asp Thr Asp  Glu Asp Lys Thr Ser  Val His Phe 
    1025                 1030                 1035             


Glu Glu  Asp Phe His Lys Leu  Arg Glu Leu Gln Thr  Thr Glu Leu 
    1040                 1045                 1050             


Lys Met  Cys Ser Leu Ala Val  Thr Pro Asn Gly His  Leu Glu Gly 
    1055                 1060                 1065             


Arg Gly  Ser Leu Ser Pro Pro  Leu Ile Met Cys Thr  Ala Ala Thr 
    1070                 1075                 1080             


Pro Met  Pro Thr Pro Lys Ser  Ser Pro Phe Leu Asp  Ala Ala Pro 
    1085                 1090                 1095             


Ser Leu  Pro Asp Ser Arg Arg  Gly Ser Ser Ser Ser  Gly Asp Pro 
    1100                 1105                 1110             


Pro Leu  Gly Asp Gln Lys Pro  Pro Ala Ser Leu Arg  Ser Ser Pro 
    1115                 1120                 1125             


Cys Ala  Pro Trp Gly Pro Ser  Gly Ala Trp Ser Ser  Arg Arg Ser 
    1130                 1135                 1140             


Ser Trp  Ser Ser Leu Gly Arg  Ala Pro Ser Leu Lys  Arg Arg Gly 
    1145                 1150                 1155             


Gln Cys  Gly Glu Arg Glu Ser  Leu Leu Ser Gly Glu  Gly Lys Gly 
    1160                 1165                 1170             


Ser Thr  Asp Asp Glu Ala Glu  Asp Gly Arg Ala Ala  Pro Gly Pro 
    1175                 1180                 1185             


Arg Ala  Thr Pro Leu Arg Arg  Ala Glu Ser Leu Asp  Pro Arg Pro 
    1190                 1195                 1200             


Leu Arg  Pro Ala Ala Leu Pro  Pro Thr Lys Cys Arg  Asp Arg Asp 
    1205                 1210                 1215             


Gly Gln  Val Val Ala Leu Pro  Ser Asp Phe Phe Leu  Arg Ile Asp 
    1220                 1225                 1230             


Ser His  Arg Glu Asp Ala Ala  Glu Leu Asp Asp Asp  Ser Glu Asp 
    1235                 1240                 1245             


Ser Cys  Cys Leu Arg Leu His  Lys Val Leu Glu Pro  Tyr Lys Pro 
    1250                 1255                 1260             


Gln Trp  Cys Arg Ser Arg Glu  Ala Trp Ala Leu Tyr  Leu Phe Ser 
    1265                 1270                 1275             


Pro Gln  Asn Arg Phe Arg Val  Ser Cys Gln Lys Val  Ile Thr His 
    1280                 1285                 1290             


Lys Met  Phe Asp His Val Val  Leu Val Phe Ile Phe  Leu Asn Cys 
    1295                 1300                 1305             


Val Thr  Ile Ala Leu Glu Arg  Pro Asp Ile Asp Pro  Gly Ser Thr 
    1310                 1315                 1320             


Glu Arg  Val Phe Leu Ser Val  Ser Asn Tyr Ile Phe  Thr Ala Ile 
    1325                 1330                 1335             


Phe Val  Ala Glu Met Met Val  Lys Val Val Ala Leu  Gly Leu Leu 
    1340                 1345                 1350             


Ser Gly  Glu His Ala Tyr Leu  Gln Ser Ser Trp Asn  Leu Leu Asp 
    1355                 1360                 1365             


Gly Leu  Leu Val Leu Val Ser  Leu Val Asp Ile Val  Val Ala Met 
    1370                 1375                 1380             


Ala Ser  Ala Gly Gly Ala Lys  Ile Leu Gly Val Leu  Arg Val Leu 
    1385                 1390                 1395             


Arg Leu  Leu Arg Thr Leu Arg  Pro Leu Arg Val Ile  Ser Arg Ala 
    1400                 1405                 1410             


Pro Gly  Leu Lys Leu Val Val  Glu Thr Leu Ile Ser  Ser Leu Arg 
    1415                 1420                 1425             


Pro Ile  Gly Asn Ile Val Leu  Ile Cys Cys Ala Phe  Phe Ile Ile 
    1430                 1435                 1440             


Phe Gly  Ile Leu Gly Val Gln  Leu Phe Lys Gly Lys  Phe Tyr Tyr 
    1445                 1450                 1455             


Cys Glu  Gly Pro Asp Thr Arg  Asn Ile Ser Thr Lys  Ala Gln Cys 
    1460                 1465                 1470             


Arg Ala  Ala His Tyr Arg Trp  Val Arg Arg Lys Tyr  Asn Phe Asp 
    1475                 1480                 1485             


Asn Leu  Gly Gln Ala Leu Met  Ser Leu Phe Val Leu  Ser Ser Lys 
    1490                 1495                 1500             


Asp Gly  Trp Val Asn Ile Met  Tyr Asp Gly Leu Asp  Ala Val Gly 
    1505                 1510                 1515             


Val Asp  Gln Gln Pro Val Gln  Asn His Asn Pro Trp  Met Leu Leu 
    1520                 1525                 1530             


Tyr Phe  Ile Ser Phe Leu Leu  Ile Val Ser Phe Phe  Val Leu Asn 
    1535                 1540                 1545             


Met Phe  Val Gly Val Val Val  Glu Asn Phe His Lys  Cys Arg Gln 
    1550                 1555                 1560             


His Gln  Glu Ala Glu Glu Ala  Arg Arg Arg Glu Glu  Lys Arg Leu 
    1565                 1570                 1575             


Arg Arg  Leu Glu Arg Arg Arg  Arg Lys Ala Gln Arg  Arg Pro Tyr 
    1580                 1585                 1590             


Tyr Ala  Asp Tyr Ser Pro Thr  Arg Arg Ser Ile His  Ser Leu Cys 
    1595                 1600                 1605             


Thr Ser  His Tyr Leu Asp Leu  Phe Ile Thr Phe Ile  Ile Cys Val 
    1610                 1615                 1620             


Asn Val  Ile Thr Met Ser Met  Glu His Tyr Asn Gln  Pro Lys Ser 
    1625                 1630                 1635             


Leu Asp  Glu Ala Leu Lys Tyr  Cys Asn Tyr Val Phe  Thr Ile Val 
    1640                 1645                 1650             


Phe Val  Phe Glu Ala Ala Leu  Lys Leu Val Ala Phe  Gly Phe Arg 
    1655                 1660                 1665             


Arg Phe  Phe Lys Asp Arg Trp  Asn Gln Leu Asp Leu  Ala Ile Val 
    1670                 1675                 1680             


Leu Leu  Ser Leu Met Gly Ile  Thr Leu Glu Glu Ile  Glu Met Ser 
    1685                 1690                 1695             


Ala Ala  Leu Pro Ile Asn Pro  Thr Ile Ile Arg Ile  Met Arg Val 
    1700                 1705                 1710             


Leu Arg  Ile Ala Arg Val Leu  Lys Leu Leu Lys Met  Ala Thr Gly 
    1715                 1720                 1725             


Met Arg  Ala Leu Leu Asp Thr  Val Val Gln Ala Leu  Pro Gln Val 
    1730                 1735                 1740             


Gly Asn  Leu Gly Leu Leu Phe  Met Leu Leu Phe Phe  Ile Tyr Ala 
    1745                 1750                 1755             


Ala Leu  Gly Val Glu Leu Phe  Gly Arg Leu Glu Cys  Ser Glu Asp 
    1760                 1765                 1770             


Asn Pro  Cys Glu Gly Leu Ser  Arg His Ala Thr Phe  Ser Asn Phe 
    1775                 1780                 1785             


Gly Met  Ala Phe Leu Thr Leu  Phe Arg Val Ser Thr  Gly Asp Asn 
    1790                 1795                 1800             


Trp Asn  Gly Ile Met Lys Asp  Thr Leu Arg Glu Cys  Ser Arg Glu 
    1805                 1810                 1815             


Asp Lys  His Cys Leu Ser Tyr  Leu Pro Ala Leu Ser  Pro Val Tyr 
    1820                 1825                 1830             


Phe Val  Thr Phe Val Leu Val  Ala Gln Phe Val Leu  Val Asn Val 
    1835                 1840                 1845             


Val Val  Ala Val Leu Met Lys  His Leu Glu Glu Ser  Asn Lys Glu 
    1850                 1855                 1860             


Ala Arg  Glu Asp Ala Glu Leu  Asp Ala Glu Ile Glu  Leu Glu Met 
    1865                 1870                 1875             


Ala Gln  Gly Pro Gly Ser Ala  Arg Arg Val Asp Ala  Asp Arg Pro 
    1880                 1885                 1890             


Pro Leu  Pro Gln Glu Ser Pro  Gly Ala Arg Asp Ala  Pro Asn Leu 
    1895                 1900                 1905             


Val Ala  Arg Lys Val Ser Val  Ser Arg Met Leu Ser  Leu Pro Asn 
    1910                 1915                 1920             


Asp Ser  Tyr Met Phe Arg Pro  Val Val Pro Ala Ser  Ala Pro His 
    1925                 1930                 1935             


Pro Arg  Pro Leu Gln Glu Val  Glu Met Glu Thr Tyr  Gly Ala Gly 
    1940                 1945                 1950             


Thr Pro  Leu Gly Ser Val Ala  Ser Val His Ser Pro  Pro Ala Glu 
    1955                 1960                 1965             


Ser Cys  Ala Ser Leu Gln Ile  Pro Leu Ala Val Ser  Ser Pro Ala 
    1970                 1975                 1980             


Arg Ser  Gly Glu Pro Leu His  Ala Leu Ser Pro Arg  Gly Thr Ala 
    1985                 1990                 1995             


Arg Ser  Pro Ser Leu Ser Arg  Leu Leu Cys Arg Gln  Glu Ala Val 
    2000                 2005                 2010             


His Thr  Asp Ser Leu Glu Gly  Lys Ile Asp Ser Pro  Arg Asp Thr 
    2015                 2020                 2025             


Leu Asp  Pro Ala Glu Pro Gly  Glu Lys Thr Pro Val  Arg Pro Val 
    2030                 2035                 2040             


Thr Gln  Gly Gly Ser Leu Gln  Ser Pro Pro Arg Ser  Pro Arg Pro 
    2045                 2050                 2055             


Ala Ser  Val Arg Thr Arg Lys  His Thr Phe Gly Gln  Arg Cys Val 
    2060                 2065                 2070             


Ser Ser  Arg Pro Ala Ala Pro  Gly Gly Glu Glu Ala  Glu Ala Ser 
    2075                 2080                 2085             


Asp Pro  Ala Asp Glu Glu Val  Ser His Ile Thr Ser  Ser Ala Cys 
    2090                 2095                 2100             


Pro Trp  Gln Pro Thr Ala Glu  Pro His Gly Pro Glu  Ala Ser Pro 
    2105                 2110                 2115             


Val Ala  Gly Gly Glu Arg Asp  Leu Arg Arg Leu Tyr  Ser Val Asp 
    2120                 2125                 2130             


Ala Gln  Gly Phe Leu Asp Lys  Pro Gly Arg Ala Asp  Glu Gln Trp 
    2135                 2140                 2145             


Arg Pro  Ser Ala Glu Leu Gly  Ser Gly Glu Pro Gly  Glu Ala Lys 
    2150                 2155                 2160             


Ala Trp  Gly Pro Glu Ala Glu  Pro Ala Leu Gly Ala  Arg Arg Lys 
    2165                 2170                 2175             


Lys Lys  Met Ser Pro Pro Cys  Ile Ser Val Glu Pro  Pro Ala Glu 
    2180                 2185                 2190             


Asp Glu  Gly Ser Ala Arg Pro  Ser Ala Ala Glu Gly  Gly Ser Thr 
    2195                 2200                 2205             


Thr Leu  Arg Arg Arg Thr Pro  Ser Cys Glu Ala Thr  Pro His Arg 
    2210                 2215                 2220             


Asp Ser  Leu Glu Pro Thr Glu  Gly Ser Gly Ala Gly  Gly Asp Pro 
    2225                 2230                 2235             


Ala Ala  Lys Gly Glu Arg Trp  Gly Gln Ala Ser Cys  Arg Ala Glu 
    2240                 2245                 2250             


His Leu  Thr Val Pro Ser Phe  Ala Phe Glu Pro Leu  Asp Leu Gly 
    2255                 2260                 2265             


Val Pro  Ser Gly Asp Pro Phe  Leu Asp Gly Ser His  Ser Val Thr 
    2270                 2275                 2280             


Pro Glu  Ser Arg Ala Ser Ser  Ser Gly Ala Ile Val  Pro Leu Glu 
    2285                 2290                 2295             


Pro Pro  Glu Ser Glu Pro Pro  Met Pro Val Gly Asp  Pro Pro Glu 
    2300                 2305                 2310             


Lys Arg  Arg Gly Leu Tyr Leu  Thr Val Pro Gln Cys  Pro Leu Glu 
    2315                 2320                 2325             


Lys Pro  Gly Ser Pro Ser Ala  Thr Pro Ala Pro Gly  Gly Gly Ala 
    2330                 2335                 2340             


Asp Asp  Pro Val 
    2345         


<210>  459
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  459

Met Leu Ala Arg Asn Asn Ser Leu Val Thr Glu Phe Ile Leu Ala Gly 
1               5                   10                  15      


Leu Thr Asp His Pro Glu Phe Arg Gln Pro Leu Phe Phe Leu Phe Leu 
            20                  25                  30          


Val Ile Tyr Ile Val Thr Met Val Gly Asn Leu Gly Leu Ile Thr Leu 
        35                  40                  45              


Phe Gly Leu Asn Ser His Leu His Thr Pro Met Tyr Tyr Phe Leu Phe 
    50                  55                  60                  


Asn Leu Ser Phe Ile Asp Leu Cys Tyr Ser Ser Val Phe Thr Pro Lys 
65                  70                  75                  80  


Met Leu Met Asn Phe Val Ser Lys Lys Asn Ile Ile Ser Asn Val Gly 
                85                  90                  95      


Cys Met Thr Arg Leu Phe Phe Phe Leu Phe Phe Val Ile Ser Glu Cys 
            100                 105                 110         


Tyr Met Leu Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 
        115                 120                 125             


Pro Leu Leu Tyr Lys Val Thr Met Ser His Gln Val Cys Ser Met Leu 
    130                 135                 140                 


Thr Phe Ala Ala Tyr Ile Met Gly Leu Ala Gly Ala Thr Ala His Thr 
145                 150                 155                 160 


Gly Cys Met Leu Arg Leu Thr Phe Cys Ser Ala Asn Ile Ile Asn His 
                165                 170                 175     


Tyr Leu Cys Asp Ile Leu Pro Leu Leu Gln Leu Ser Cys Thr Ser Thr 
            180                 185                 190         


Tyr Val Asn Glu Val Val Val Leu Ile Val Val Gly Thr Asn Ile Thr 
        195                 200                 205             


Val Pro Ser Cys Thr Ile Leu Ile Ser Tyr Val Phe Ile Val Thr Ser 
    210                 215                 220                 


Ile Leu His Ile Lys Ser Thr Gln Gly Arg Ser Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Ser Ser His Val Ile Ala Leu Ser Leu Phe Phe Gly Ser Ala Ala 
                245                 250                 255     


Phe Met Tyr Ile Lys Tyr Ser Ser Gly Ser Met Glu Gln Gly Lys Val 
            260                 265                 270         


Ser Ser Val Phe Tyr Thr Asn Val Val Pro Met Leu Asn Pro Leu Ile 
        275                 280                 285             


Tyr Ser Leu Arg Asn Lys Asp Val Lys Val Ala Leu Arg Lys Ala Leu 
    290                 295                 300                 


Ile Lys Ile Gln Arg Arg Asn Ile Phe 
305                 310             


<210>  460
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  460

Met Ala Asp Asp Asn Phe Thr Val Val Thr Glu Phe Ile Leu Leu Gly 
1               5                   10                  15      


Leu Thr Asp His Ala Glu Leu Lys Ala Val Leu Phe Val Val Phe Leu 
            20                  25                  30          


Val Ile Tyr Ala Ile Thr Leu Leu Arg Asn Leu Gly Met Ile Leu Leu 
        35                  40                  45              


Ile Gln Ile Thr Ser Lys Leu His Thr Pro Met Tyr Phe Leu Leu Ser 
    50                  55                  60                  


Cys Leu Ser Phe Val Asp Ala Cys Tyr Ser Ser Ala Ile Ala Pro Lys 
65                  70                  75                  80  


Met Leu Val Asn Leu Leu Val Val Lys Ala Thr Ile Ser Phe Ser Ala 
                85                  90                  95      


Cys Met Val Gln His Leu Cys Phe Gly Val Phe Ile Thr Thr Glu Gly 
            100                 105                 110         


Phe Leu Leu Ser Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Val Ser 
        115                 120                 125             


Pro Leu Leu Tyr Thr Val Ala Met Ser Asp Arg Lys Cys Val Glu Leu 
    130                 135                 140                 


Val Thr Gly Ser Trp Ile Gly Gly Ile Val Asn Thr Leu Ile His Thr 
145                 150                 155                 160 


Ile Ser Leu Arg Arg Leu Ser Phe Cys Arg Leu Asn Ala Val Ser His 
                165                 170                 175     


Phe Phe Cys Asp Ile Pro Ser Leu Leu Lys Leu Ser Cys Ser Asp Thr 
            180                 185                 190         


Ser Met Asn Glu Leu Leu Leu Leu Thr Phe Ser Gly Val Ile Ala Met 
        195                 200                 205             


Ala Thr Phe Leu Thr Val Ile Ile Ser Tyr Ile Phe Ile Ala Phe Ala 
    210                 215                 220                 


Ser Leu Arg Ile His Ser Ala Ser Gly Arg Gln Gln Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Ala Ser His Leu Thr Ala Val Thr Ile Phe Tyr Gly Thr Leu Ile 
                245                 250                 255     


Phe Ser Tyr Ile Gln Pro Ser Ser Gln Tyr Phe Val Glu Gln Glu Lys 
            260                 265                 270         


Val Val Ser Met Phe Tyr Thr Leu Gly Ile Pro Met Leu Asn Leu Leu 
        275                 280                 285             


Ile His Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Val Lys Arg Ala 
    290                 295                 300                 


Ile Glu Met Lys His Phe Leu Cys 
305                 310         


<210>  461
<211>  827
<212>  PRT
<213>  Homo sapiens

<400>  461

Met Ala Ser Ala Asp Lys Asn Gly Gly Ser Val Ser Ser Val Ser Ser 
1               5                   10                  15      


Ser Arg Leu Gln Ser Arg Lys Pro Pro Asn Leu Ser Ile Thr Ile Pro 
            20                  25                  30          


Pro Pro Glu Lys Glu Thr Gln Ala Pro Gly Glu Gln Asp Ser Met Leu 
        35                  40                  45              


Pro Glu Arg Lys Asn Pro Ala Tyr Leu Lys Ser Val Ser Leu Gln Glu 
    50                  55                  60                  


Pro Arg Ser Arg Trp Gln Glu Ser Ser Glu Lys Arg Pro Gly Phe Arg 
65                  70                  75                  80  


Arg Gln Ala Ser Leu Ser Gln Ser Ile Arg Lys Gly Ala Ala Gln Trp 
                85                  90                  95      


Phe Gly Val Ser Gly Asp Trp Glu Gly Gln Arg Gln Gln Trp Gln Arg 
            100                 105                 110         


Arg Ser Leu His His Cys Ser Met Arg Tyr Gly Arg Leu Lys Ala Ser 
        115                 120                 125             


Cys Gln Arg Asp Leu Glu Leu Pro Ser Gln Glu Ala Pro Ser Phe Gln 
    130                 135                 140                 


Gly Thr Glu Ser Pro Lys Pro Cys Lys Met Pro Lys Ile Val Asp Pro 
145                 150                 155                 160 


Leu Ala Arg Gly Arg Ala Phe Arg His Pro Glu Glu Met Asp Arg Pro 
                165                 170                 175     


His Ala Pro His Pro Pro Leu Thr Pro Gly Val Leu Ser Leu Thr Ser 
            180                 185                 190         


Phe Thr Ser Val Arg Ser Gly Tyr Ser His Leu Pro Arg Arg Lys Arg 
        195                 200                 205             


Met Ser Val Ala His Met Ser Leu Gln Ala Ala Ala Ala Leu Leu Lys 
    210                 215                 220                 


Gly Arg Ser Val Leu Asp Ala Thr Gly Gln Arg Cys Arg Val Val Lys 
225                 230                 235                 240 


Arg Ser Phe Ala Phe Pro Ser Phe Leu Glu Glu Asp Val Val Asp Gly 
                245                 250                 255     


Ala Asp Thr Phe Asp Ser Ser Phe Phe Ser Lys Glu Glu Met Ser Ser 
            260                 265                 270         


Met Pro Asp Asp Val Phe Glu Ser Pro Pro Leu Ser Ala Ser Tyr Phe 
        275                 280                 285             


Arg Gly Ile Pro His Ser Ala Ser Pro Val Ser Pro Asp Gly Val Gln 
    290                 295                 300                 


Ile Pro Leu Lys Glu Tyr Gly Arg Ala Pro Val Pro Gly Pro Arg Arg 
305                 310                 315                 320 


Gly Lys Arg Ile Ala Ser Lys Val Lys His Phe Ala Phe Asp Arg Lys 
                325                 330                 335     


Lys Arg His Tyr Gly Leu Gly Val Val Gly Asn Trp Leu Asn Arg Ser 
            340                 345                 350         


Tyr Arg Arg Ser Ile Ser Ser Thr Val Gln Arg Gln Leu Glu Ser Phe 
        355                 360                 365             


Asp Ser His Arg Pro Tyr Phe Thr Tyr Trp Leu Thr Phe Val His Val 
    370                 375                 380                 


Ile Ile Thr Leu Leu Val Ile Cys Thr Tyr Gly Ile Ala Pro Val Gly 
385                 390                 395                 400 


Phe Ala Gln His Val Thr Thr Gln Leu Val Leu Arg Asn Lys Gly Val 
                405                 410                 415     


Tyr Glu Ser Val Lys Tyr Ile Gln Gln Glu Asn Phe Trp Val Gly Pro 
            420                 425                 430         


Ser Ser Ile Asp Leu Ile His Leu Gly Ala Lys Phe Ser Pro Cys Ile 
        435                 440                 445             


Arg Lys Asp Gly Gln Ile Glu Gln Leu Val Leu Arg Glu Arg Asp Leu 
    450                 455                 460                 


Glu Arg Asp Ser Gly Cys Cys Val Gln Asn Asp His Ser Gly Cys Ile 
465                 470                 475                 480 


Gln Thr Gln Arg Lys Asp Cys Ser Glu Thr Leu Ala Thr Phe Val Lys 
                485                 490                 495     


Trp Gln Asp Asp Thr Gly Pro Pro Met Asp Lys Ser Asp Leu Gly Gln 
            500                 505                 510         


Lys Arg Thr Ser Gly Ala Val Cys His Gln Asp Pro Arg Thr Cys Glu 
        515                 520                 525             


Glu Pro Ala Ser Ser Gly Ala His Ile Trp Pro Asp Asp Ile Thr Lys 
    530                 535                 540                 


Trp Pro Ile Cys Thr Glu Gln Ala Arg Ser Asn His Thr Gly Phe Leu 
545                 550                 555                 560 


His Met Asp Cys Glu Ile Lys Gly Arg Pro Cys Cys Ile Gly Thr Lys 
                565                 570                 575     


Gly Ser Cys Glu Ile Thr Thr Arg Glu Tyr Cys Glu Phe Met His Gly 
            580                 585                 590         


Tyr Phe His Glu Glu Ala Thr Leu Cys Ser Gln Val His Cys Leu Asp 
        595                 600                 605             


Lys Val Cys Gly Leu Leu Pro Phe Leu Asn Pro Glu Val Pro Asp Gln 
    610                 615                 620                 


Phe Tyr Arg Leu Trp Leu Ser Leu Phe Leu His Ala Gly Val Val His 
625                 630                 635                 640 


Cys Leu Val Ser Val Val Phe Gln Met Thr Ile Leu Arg Asp Leu Glu 
                645                 650                 655     


Lys Leu Ala Gly Trp His Arg Ile Ala Ile Ile Phe Ile Leu Ser Gly 
            660                 665                 670         


Ile Thr Gly Asn Leu Ala Ser Ala Ile Phe Leu Pro Tyr Arg Ala Glu 
        675                 680                 685             


Val Gly Pro Ala Gly Ser Gln Phe Gly Leu Leu Ala Cys Leu Phe Val 
    690                 695                 700                 


Glu Leu Phe Gln Ser Trp Pro Leu Leu Glu Arg Pro Trp Lys Ala Phe 
705                 710                 715                 720 


Leu Asn Leu Ser Ala Ile Val Leu Phe Leu Phe Ile Cys Gly Leu Leu 
                725                 730                 735     


Pro Trp Ile Asp Asn Ile Ala His Ile Phe Gly Phe Leu Ser Gly Leu 
            740                 745                 750         


Leu Leu Ala Phe Ala Phe Leu Pro Tyr Ile Thr Phe Gly Thr Ser Asp 
        755                 760                 765             


Lys Tyr Arg Lys Arg Ala Leu Ile Leu Val Ser Leu Leu Ala Phe Ala 
    770                 775                 780                 


Gly Leu Phe Ala Ala Leu Val Leu Trp Leu Tyr Ile Tyr Pro Ile Asn 
785                 790                 795                 800 


Trp Pro Trp Ile Glu His Leu Thr Cys Phe Pro Phe Thr Ser Arg Phe 
                805                 810                 815     


Cys Glu Lys Tyr Glu Leu Asp Gln Val Leu His 
            820                 825         


<210>  462
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  462

Met Arg Ser Pro Arg Met Arg Val Cys Ala Lys Ser Val Leu Leu Ser 
1               5                   10                  15      


His Trp Leu Phe Leu Ala Tyr Val Leu Met Val Cys Cys Lys Leu Met 
            20                  25                  30          


Ser Ala Ser Ser Gln His Leu Arg Gly His Ala Gly His His Gln Ile 
        35                  40                  45              


Lys Gln Gly Thr Cys Glu Val Val Ala Val His Arg Cys Cys Asn Lys 
    50                  55                  60                  


Asn Arg Ile Glu Glu Arg Ser Gln Thr Val Lys Cys Ser Cys Phe Pro 
65                  70                  75                  80  


Gly Gln Val Ala Gly Thr Thr Arg Ala Gln Pro Ser Cys Val Glu Ala 
                85                  90                  95      


Ser Ile Val Ile Gln Lys Trp Trp Cys His Met Asn Pro Cys Leu Glu 
            100                 105                 110         


Gly Glu Asp Cys Lys Val Leu Pro Asp Tyr Ser Gly Trp Ser Cys Ser 
        115                 120                 125             


Ser Gly Asn Lys Val Lys Thr Thr Lys Val Thr Arg 
    130                 135                 140 


<210>  463
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  463

Met Ser Ser Ser Gly Ser Ser His Pro Phe Leu Leu Thr Gly Phe Pro 
1               5                   10                  15      


Gly Leu Glu Glu Ala His His Trp Ile Ser Val Phe Phe Leu Phe Met 
            20                  25                  30          


Tyr Ile Ser Ile Leu Phe Gly Asn Gly Thr Leu Leu Leu Leu Ile Lys 
        35                  40                  45              


Glu Asp His Asn Leu His Glu Pro Met Tyr Phe Phe Leu Ala Met Leu 
    50                  55                  60                  


Ala Ala Thr Asp Leu Gly Leu Ala Leu Thr Thr Met Pro Thr Val Leu 
65                  70                  75                  80  


Gly Val Leu Trp Leu Asp His Arg Glu Ile Gly Ser Ala Ala Cys Phe 
                85                  90                  95      


Ser Gln Ala Tyr Phe Ile His Ser Leu Ser Phe Leu Glu Ser Gly Ile 
            100                 105                 110         


Leu Leu Ala Met Ala Tyr Asp Arg Phe Ile Ala Ile Cys Asn Pro Leu 
        115                 120                 125             


Arg Tyr Thr Ser Val Leu Thr Asn Thr Arg Val Val Lys Ile Gly Leu 
    130                 135                 140                 


Gly Val Leu Met Arg Gly Phe Val Ser Val Val Pro Pro Ile Arg Pro 
145                 150                 155                 160 


Leu Tyr Phe Phe Leu Tyr Cys His Ser His Val Leu Ser His Ala Phe 
                165                 170                 175     


Cys Leu His Gln Asp Val Ile Lys Leu Ala Cys Ala Asp Thr Thr Phe 
            180                 185                 190         


Asn Arg Leu Tyr Pro Ala Val Leu Val Val Phe Ile Phe Val Leu Asp 
        195                 200                 205             


Tyr Leu Ile Ile Phe Ile Ser Tyr Val Leu Ile Leu Lys Thr Val Leu 
    210                 215                 220                 


Ser Ile Ala Ser Arg Glu Glu Arg Ala Lys Ala Leu Ile Thr Cys Val 
225                 230                 235                 240 


Ser His Ile Cys Cys Val Leu Val Phe Tyr Val Thr Val Ile Gly Leu 
                245                 250                 255     


Ser Leu Ile His Arg Phe Gly Lys Gln Val Pro His Ile Val His Leu 
            260                 265                 270         


Ile Met Ser Tyr Ala Tyr Phe Leu Phe Pro Pro Leu Met Asn Pro Ile 
        275                 280                 285             


Thr Tyr Ser Val Lys Thr Lys Gln Ile Gln Asn Ala Ile Leu His Leu 
    290                 295                 300                 


Phe Thr Thr His Arg Ile Gly Thr 
305                 310         


<210>  464
<211>  389
<212>  PRT
<213>  Homo sapiens

<400>  464

Met Gly Tyr Pro Glu Val Glu Arg Arg Glu Leu Leu Pro Ala Ala Ala 
1               5                   10                  15      


Pro Arg Glu Arg Gly Ser Gln Gly Cys Gly Cys Gly Gly Ala Pro Ala 
            20                  25                  30          


Arg Ala Gly Glu Gly Asn Ser Cys Leu Leu Phe Leu Gly Phe Phe Gly 
        35                  40                  45              


Leu Ser Leu Ala Leu His Leu Leu Thr Leu Cys Cys Tyr Leu Glu Leu 
    50                  55                  60                  


Arg Ser Glu Leu Arg Arg Glu Arg Gly Ala Glu Ser Arg Leu Gly Gly 
65                  70                  75                  80  


Ser Gly Thr Pro Gly Thr Ser Gly Thr Leu Ser Ser Leu Gly Gly Leu 
                85                  90                  95      


Asp Pro Asp Ser Pro Ile Thr Ser His Leu Gly Gln Pro Ser Pro Lys 
            100                 105                 110         


Gln Gln Pro Leu Glu Pro Gly Glu Ala Ala Leu His Ser Asp Ser Gln 
        115                 120                 125             


Asp Gly His Gln Met Ala Leu Leu Asn Phe Phe Phe Pro Asp Glu Lys 
    130                 135                 140                 


Pro Tyr Ser Glu Glu Glu Ser Arg Arg Val Arg Arg Asn Lys Arg Ser 
145                 150                 155                 160 


Lys Ser Asn Glu Gly Ala Asp Gly Pro Val Lys Asn Lys Lys Lys Gly 
                165                 170                 175     


Lys Lys Ala Gly Pro Pro Gly Pro Asn Gly Pro Pro Gly Pro Pro Gly 
            180                 185                 190         


Pro Pro Gly Pro Gln Gly Pro Pro Gly Ile Pro Gly Ile Pro Gly Ile 
        195                 200                 205             


Pro Gly Thr Thr Val Met Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
    210                 215                 220                 


Pro Gln Gly Pro Pro Gly Leu Gln Gly Pro Ser Gly Ala Ala Asp Lys 
225                 230                 235                 240 


Ala Gly Thr Arg Glu Asn Gln Pro Ala Val Val His Leu Gln Gly Gln 
                245                 250                 255     


Gly Ser Ala Ile Gln Val Lys Asn Asp Leu Ser Gly Gly Val Leu Asn 
            260                 265                 270         


Asp Trp Ser Arg Ile Thr Met Asn Pro Lys Val Phe Lys Leu His Pro 
        275                 280                 285             


Arg Ser Gly Glu Leu Glu Val Leu Val Asp Gly Thr Tyr Phe Ile Tyr 
    290                 295                 300                 


Ser Gln Val Tyr Tyr Ile Asn Phe Thr Asp Phe Ala Ser Tyr Glu Val 
305                 310                 315                 320 


Val Val Asp Glu Lys Pro Phe Leu Gln Cys Thr Arg Ser Ile Glu Thr 
                325                 330                 335     


Gly Lys Thr Asn Tyr Asn Thr Cys Tyr Thr Ala Gly Val Cys Leu Leu 
            340                 345                 350         


Lys Ala Arg Gln Lys Ile Ala Val Lys Met Val His Ala Asp Ile Ser 
        355                 360                 365             


Ile Asn Met Ser Lys His Thr Thr Phe Phe Gly Ala Ile Arg Leu Gly 
    370                 375                 380                 


Glu Ala Pro Ala Ser 
385                 


<210>  465
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  465

Met Gly Tyr Pro Glu Val Glu Arg Arg Glu Leu Leu Pro Ala Ala Ala 
1               5                   10                  15      


Pro Arg Glu Arg Gly Ser Gln Gly Cys Gly Cys Gly Gly Ala Pro Ala 
            20                  25                  30          


Arg Ala Gly Glu Gly Asn Ser Cys Leu Leu Phe Leu Gly Phe Phe Gly 
        35                  40                  45              


Leu Ser Leu Ala Leu His Leu Leu Thr Leu Cys Cys Tyr Leu Glu Leu 
    50                  55                  60                  


Arg Ser Glu Leu Arg Arg Glu Arg Gly Ala Glu Ser Arg Leu Gly Gly 
65                  70                  75                  80  


Ser Gly Thr Pro Gly Thr Ser Gly Thr Leu Ser Ser Leu Gly Gly Leu 
                85                  90                  95      


Asp Pro Asp Ser Pro Ile Thr Ser His Leu Gly Gln Pro Ser Pro Lys 
            100                 105                 110         


Gln Gln Pro Leu Glu Pro Gly Glu Ala Ala Leu His Ser Asp Ser Gln 
        115                 120                 125             


Asp Gly His Gln Gly His Gln 
    130                 135 


<210>  466
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  466

Met Gly Tyr Pro Glu Val Glu Arg Arg Glu Leu Leu Pro Ala Ala Ala 
1               5                   10                  15      


Pro Arg Glu Arg Gly Ser Gln Gly Cys Gly Cys Gly Gly Ala Pro Ala 
            20                  25                  30          


Arg Ala Gly Glu Gly Asn Ser Cys Leu Leu Phe Leu Gly Phe Phe Gly 
        35                  40                  45              


Leu Ser Leu Ala Leu His Leu Leu Thr Leu Cys Cys Tyr Leu Glu Leu 
    50                  55                  60                  


Arg Ser Glu Leu Arg Arg Glu Arg Gly Ala Glu Ser Arg Leu Gly Gly 
65                  70                  75                  80  


Ser Gly Thr Pro Gly Thr Ser Gly Thr Leu Ser Ser Leu Gly Gly Leu 
                85                  90                  95      


Asp Pro Asp Ser Pro Ile Thr Ser His Leu Gly Gln Pro Ser Pro Lys 
            100                 105                 110         


Gln Gln Pro Leu Glu Pro Gly Glu Ala Ala Leu His Ser Asp Ser Gln 
        115                 120                 125             


Asp Gly His Gln Val Ser His Leu Val Gly Ala Ala Ala Ala Pro Ser 
    130                 135                 140                 


Pro Arg Gly 
145         


<210>  467
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  467

Met Gly Tyr Pro Glu Val Glu Arg Arg Glu Leu Leu Pro Ala Ala Ala 
1               5                   10                  15      


Pro Arg Glu Arg Gly Ser Gln Gly Cys Gly Cys Gly Gly Ala Pro Ala 
            20                  25                  30          


Arg Ala Gly Glu Gly Asn Ser Cys Leu Leu Phe Leu Gly Phe Phe Gly 
        35                  40                  45              


Leu Ser Leu Ala Leu His Leu Leu Thr Leu Cys Cys Tyr Leu Glu Leu 
    50                  55                  60                  


Arg Ser Glu Leu Arg Arg Glu Arg Gly Ala Glu Ser Arg Leu Gly Gly 
65                  70                  75                  80  


Ser Gly Thr Pro Gly Thr Ser Gly Thr Leu Ser Ser Leu Gly Gly Leu 
                85                  90                  95      


Asp Pro Asp Ser Pro Ile Thr Ser His Leu Gly Gln Pro Ser Pro Lys 
            100                 105                 110         


Gln Gln Pro Leu Glu Pro Gly Glu Ala Ala Leu His Ser Asp Ser Gln 
        115                 120                 125             


Asp Gly His Gln Met Ala Leu Leu Asn Phe Phe Phe Pro Asp Glu Lys 
    130                 135                 140                 


Pro Tyr Ser Glu Glu Glu Ser Arg Arg Val Arg Arg Asn Lys Arg Ser 
145                 150                 155                 160 


Lys Ser Asn Glu Gly Ala Asp Gly Pro Val Lys Asn Lys Lys Lys Gly 
                165                 170                 175     


Lys Lys Ala Gly Pro Pro Gly Pro Asn Gly Pro Pro Gly Pro Pro Gly 
            180                 185                 190         


Pro Pro Gly Pro Gln Gly Pro Pro Gly Ile Pro Gly Ile Pro Gly Ile 
        195                 200                 205             


Pro Gly Thr Thr Val Met Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
    210                 215                 220                 


Pro Gln Gly Pro Pro Gly Leu Gln Gly Pro Ser Gly Ala Ala Asp Lys 
225                 230                 235                 240 


Ala Gly Thr Arg Glu Asn Gln Pro Ala Val Val His Leu Gln Gly Gln 
                245                 250                 255     


Gly Ser Ala Ile Gln Val Lys Asn Gly Gly Val Leu Asn Asp Trp Ser 
            260                 265                 270         


Arg Ile Thr Met Asn Pro Lys Val Phe Lys Leu His Pro Arg Ser Gly 
        275                 280                 285             


Glu Leu Glu Val Leu Val Asp Gly Thr Tyr Phe Ile Tyr Ser Gln Val 
    290                 295                 300                 


Tyr Tyr Ile Asn Phe Thr Asp Phe Ala Ser Tyr Glu Val Val Val Asp 
305                 310                 315                 320 


Glu Lys Pro Phe Leu Gln Cys Thr Arg Ser Ile Glu Thr Gly Lys Thr 
                325                 330                 335     


Asn Tyr Asn Thr Cys Tyr Thr Ala Gly Val Cys Leu Leu Lys Ala Arg 
            340                 345                 350         


Gln Lys Ile Ala Val Lys Met Val His Ala Asp Ile Ser Ile Asn Met 
        355                 360                 365             


Ser Lys His Thr Thr Phe Phe Gly Ala Ile Arg Leu Gly Glu Ala Pro 
    370                 375                 380                 


Ala Ser 
385     


<210>  468
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  468

Met Gly Tyr Pro Glu Val Glu Arg Arg Glu Leu Leu Pro Ala Ala Ala 
1               5                   10                  15      


Pro Arg Glu Arg Gly Ser Gln Gly Cys Gly Cys Gly Gly Ala Pro Ala 
            20                  25                  30          


Arg Ala Gly Glu Gly Asn Ser Cys Leu Leu Phe Leu Gly Phe Phe Gly 
        35                  40                  45              


Leu Ser Leu Ala Leu His Leu Leu Thr Leu Cys Cys Tyr Leu Glu Leu 
    50                  55                  60                  


Arg Ser Glu Leu Arg Arg Glu Arg Gly Ala Glu Ser Arg Leu Gly Gly 
65                  70                  75                  80  


Ser Gly Thr Pro Gly Thr Ser Gly Thr Leu Ser Ser Leu Gly Gly Leu 
                85                  90                  95      


Asp Pro Asp Ser Pro Ile Thr Ser His Leu Gly Gln Pro Ser Pro Lys 
            100                 105                 110         


Gln Gln Pro Leu Glu Pro Gly Glu Ala Ala Leu His Ser Asp Ser Gln 
        115                 120                 125             


Asp Gly His Gln Gly His Gln 
    130                 135 


<210>  469
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  469

Met Glu Thr Asn Phe Ser Thr Pro Leu Asn Glu Tyr Glu Glu Val Ser 
1               5                   10                  15      


Tyr Glu Ser Ala Gly Tyr Thr Val Leu Arg Ile Leu Pro Leu Val Val 
            20                  25                  30          


Leu Gly Val Thr Phe Val Leu Gly Val Leu Gly Asn Gly Leu Val Ile 
        35                  40                  45              


Trp Val Ala Gly Phe Arg Met Thr Arg Thr Val Thr Thr Ile Cys Tyr 
    50                  55                  60                  


Leu Asn Leu Ala Leu Ala Asp Phe Ser Phe Thr Ala Thr Leu Pro Phe 
65                  70                  75                  80  


Leu Ile Val Ser Met Ala Met Gly Glu Lys Trp Pro Phe Gly Trp Phe 
                85                  90                  95      


Leu Cys Lys Leu Ile His Ile Val Val Asp Ile Asn Leu Phe Gly Ser 
            100                 105                 110         


Val Phe Leu Ile Gly Phe Ile Ala Leu Asp Arg Cys Ile Cys Val Leu 
        115                 120                 125             


His Pro Val Trp Ala Gln Asn His Arg Thr Val Ser Leu Ala Met Lys 
    130                 135                 140                 


Val Ile Val Gly Pro Trp Ile Leu Ala Leu Val Leu Thr Leu Pro Val 
145                 150                 155                 160 


Phe Leu Phe Leu Thr Thr Val Thr Ile Pro Asn Gly Asp Thr Tyr Cys 
                165                 170                 175     


Thr Phe Asn Phe Ala Ser Trp Gly Gly Thr Pro Glu Glu Arg Leu Lys 
            180                 185                 190         


Val Ala Ile Thr Met Leu Thr Ala Arg Gly Ile Ile Arg Phe Val Ile 
        195                 200                 205             


Gly Phe Ser Leu Pro Met Ser Ile Val Ala Ile Cys Tyr Gly Leu Ile 
    210                 215                 220                 


Ala Ala Lys Ile His Lys Lys Gly Met Ile Lys Ser Ser Arg Pro Leu 
225                 230                 235                 240 


Arg Val Leu Thr Ala Val Val Ala Ser Phe Phe Ile Cys Trp Phe Pro 
                245                 250                 255     


Phe Gln Leu Val Ala Leu Leu Gly Thr Val Trp Leu Lys Glu Met Leu 
            260                 265                 270         


Phe Tyr Gly Lys Tyr Lys Ile Ile Asp Ile Leu Val Asn Pro Thr Ser 
        275                 280                 285             


Ser Leu Ala Phe Phe Asn Ser Cys Leu Asn Pro Met Leu Tyr Val Phe 
    290                 295                 300                 


Val Gly Gln Asp Phe Arg Glu Arg Leu Ile His Ser Leu Pro Thr Ser 
305                 310                 315                 320 


Leu Glu Arg Ala Leu Ser Glu Asp Ser Ala Pro Thr Asn Asp Thr Ala 
                325                 330                 335     


Ala Asn Ser Ala Ser Pro Pro Ala Glu Thr Glu Leu Gln Ala Met 
            340                 345                 350     


<210>  470
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  470

Met Asp Trp Lys Thr Leu Gln Ala Leu Leu Ser Gly Val Asn Lys Tyr 
1               5                   10                  15      


Ser Thr Ala Phe Gly Arg Ile Trp Leu Ser Val Val Phe Val Phe Arg 
            20                  25                  30          


Val Leu Val Tyr Val Val Ala Ala Glu Arg Val Trp Gly Asp Glu Gln 
        35                  40                  45              


Lys Asp Phe Asp Cys Asn Thr Lys Gln Pro Gly Cys Thr Asn Val Cys 
    50                  55                  60                  


Tyr Asp Asn Tyr Phe Pro Ile Ser Asn Ile Arg Leu Trp Ala Leu Gln 
65                  70                  75                  80  


Leu Ile Phe Val Thr Cys Pro Ser Leu Leu Val Ile Leu His Val Ala 
                85                  90                  95      


Tyr Arg Glu Glu Arg Glu Arg Arg His Arg Gln Lys His Gly Asp Gln 
            100                 105                 110         


Cys Ala Lys Leu Tyr Asp Asn Ala Gly Lys Lys His Gly Gly Leu Trp 
        115                 120                 125             


Trp Thr Tyr Leu Phe Ser Leu Ile Phe Lys Leu Ile Ile Glu Phe Leu 
    130                 135                 140                 


Phe Leu Tyr Leu Leu His Thr Leu Trp His Gly Phe Asn Met Pro Arg 
145                 150                 155                 160 


Leu Val Gln Cys Ala Asn Val Ala Pro Cys Pro Asn Ile Val Asp Cys 
                165                 170                 175     


Tyr Ile Ala Arg Pro Thr Glu Lys Lys Ile Phe Thr Tyr Phe Met Val 
            180                 185                 190         


Gly Ala Ser Ala Val Cys Ile Val Leu Thr Ile Cys Glu Leu Cys Tyr 
        195                 200                 205             


Leu Ile Cys His Arg Val Leu Arg Gly Leu His Lys Asp Lys Pro Arg 
    210                 215                 220                 


Gly Gly Cys Ser Pro Ser Ser Ser Ala Ser Arg Ala Ser Thr Cys Arg 
225                 230                 235                 240 


Cys His His Lys Leu Val Glu Ala Gly Glu Val Asp Pro Asp Pro Gly 
                245                 250                 255     


Asn Asn Lys Leu Gln Ala Ser Ala Pro Asn Leu Thr Pro Ile 
            260                 265                 270 


<210>  471
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  471

Met Ile Arg Ser Arg Lys Ala Val Ser Lys Leu Tyr Ala Ser Lys Ala 
1               5                   10                  15      


His Met Asn Ser Val Leu Met Gly Met Lys Asn Gln Leu Ala Val Leu 
            20                  25                  30          


Arg Val Ala Gly Ser Leu Gln Lys Ser Thr Glu Val Met Lys Ala Met 
        35                  40                  45              


Gln Ser Leu Val Lys Ile Pro Glu Ile Gln Ala Thr Met Arg Glu Leu 
    50                  55                  60                  


Ser Lys Glu Met Met Lys Ala Gly Ile Ile Glu Glu Met Leu Glu Asp 
65                  70                  75                  80  


Thr Phe Glu Ser Met Asp Asp Gln Glu Glu Met Glu Glu Glu Ala Glu 
                85                  90                  95      


Met Glu Ile Asp Arg Ile Leu Phe Glu Ile Thr Ala Gly Ala Leu Gly 
            100                 105                 110         


Lys Ala Pro Ser Lys Val Thr Asp Ala Leu Pro Glu Pro Glu Pro Pro 
        115                 120                 125             


Gly Ala Met Ala Ala Ser Glu Asp Glu Glu Glu Glu Glu Glu Ala Leu 
    130                 135                 140                 


Glu Ala Met Gln Ser Arg Leu Ala Thr Leu Arg Ser 
145                 150                 155     


<210>  472
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  472

Met Gly Ser Gly Ala Arg Phe Pro Ser Gly Thr Leu Arg Val Arg Trp 
1               5                   10                  15      


Leu Leu Leu Leu Gly Leu Val Gly Pro Val Leu Gly Ala Ala Arg Pro 
            20                  25                  30          


Gly Phe Gln Gln Thr Ser His Leu Ser Ser Tyr Glu Ile Ile Thr Pro 
        35                  40                  45              


Trp Arg Leu Thr Arg Glu Arg Arg Glu Ala Pro Arg Pro Tyr Ser Lys 
    50                  55                  60                  


Gln Val Ser Tyr Val Ile Gln Ala Glu Gly Lys Glu His Ile Ile His 
65                  70                  75                  80  


Leu Glu Arg Asn Lys Asp Leu Leu Pro Glu Asp Phe Val Val Tyr Thr 
                85                  90                  95      


Tyr Asn Lys Glu Gly Thr Leu Ile Thr Asp His Pro Asn Ile Gln Asn 
            100                 105                 110         


His Cys His Tyr Arg Gly Tyr Val Glu Gly Val His Asn Ser Ser Ile 
        115                 120                 125             


Ala Leu Ser Asp Cys Phe Gly Leu Arg Gly Leu Leu His Leu Glu Asn 
    130                 135                 140                 


Ala Ser Tyr Gly Ile Glu Pro Leu Gln Asn Ser Ser His Phe Glu His 
145                 150                 155                 160 


Ile Ile Tyr Arg Met Asp Asp Val Tyr Lys Glu Pro Leu Lys Cys Gly 
                165                 170                 175     


Val Ser Asn Lys Asp Ile Glu Lys Glu Thr Ala Lys Asp Glu Glu Glu 
            180                 185                 190         


Glu Pro Pro Ser Met Thr Gln Leu Leu Arg Arg Arg Arg Ala Val Leu 
        195                 200                 205             


Pro Gln Thr Arg Tyr Val Glu Leu Phe Ile Val Val Asp Lys Glu Arg 
    210                 215                 220                 


Tyr Asp Met Met Gly Arg Asn Gln Thr Ala Val Arg Glu Glu Met Ile 
225                 230                 235                 240 


Leu Leu Ala Asn Tyr Leu Asp Ser Met Tyr Ile Met Leu Asn Ile Arg 
                245                 250                 255     


Ile Val Leu Val Gly Leu Glu Ile Trp Thr Asn Gly Asn Leu Ile Asn 
            260                 265                 270         


Ile Val Gly Gly Ala Gly Asp Val Leu Gly Asn Phe Val Gln Trp Arg 
        275                 280                 285             


Glu Lys Phe Leu Ile Thr Arg Arg Arg His Asp Ser Ala Gln Leu Val 
    290                 295                 300                 


Leu Lys Lys Gly Phe Gly Gly Thr Ala Gly Met Ala Phe Val Gly Thr 
305                 310                 315                 320 


Val Cys Ser Arg Ser His Ala Gly Gly Ile Asn Val Phe Gly Gln Ile 
                325                 330                 335     


Thr Val Glu Thr Phe Ala Ser Ile Val Ala His Glu Leu Gly His Asn 
            340                 345                 350         


Leu Gly Met Asn His Asp Asp Gly Arg Asp Cys Ser Cys Gly Ala Lys 
        355                 360                 365             


Ser Cys Ile Met Asn Ser Gly Ala Ser Gly Ser Arg Asn Phe Ser Ser 
    370                 375                 380                 


Cys Ser Ala Glu Asp Phe Glu Lys Leu Thr Leu Asn Lys Gly Gly Asn 
385                 390                 395                 400 


Cys Leu Leu Asn Ile Pro Lys Pro Asp Glu Ala Tyr Ser Ala Pro Ser 
                405                 410                 415     


Cys Gly Asn Lys Leu Val Asp Ala Gly Glu Glu Cys Asp Cys Gly Thr 
            420                 425                 430         


Pro Lys Glu Cys Glu Leu Asp Pro Cys Cys Glu Gly Ser Thr Cys Lys 
        435                 440                 445             


Leu Lys Ser Phe Ala Glu Cys Ala Tyr Gly Asp Cys Cys Lys Asp Cys 
    450                 455                 460                 


Arg Phe Leu Pro Gly Gly Thr Leu Cys Arg Gly Lys Thr Ser Glu Cys 
465                 470                 475                 480 


Asp Val Pro Glu Tyr Cys Asn Gly Ser Ser Gln Phe Cys Gln Pro Asp 
                485                 490                 495     


Val Phe Ile Gln Asn Gly Tyr Pro Cys Gln Asn Asn Lys Ala Tyr Cys 
            500                 505                 510         


Tyr Asn Gly Met Cys Gln Tyr Tyr Asp Ala Gln Cys Gln Val Ile Phe 
        515                 520                 525             


Gly Ser Lys Ala Lys Ala Ala Pro Lys Asp Cys Phe Ile Glu Val Asn 
    530                 535                 540                 


Ser Lys Gly Asp Arg Phe Gly Asn Cys Gly Phe Ser Gly Asn Glu Tyr 
545                 550                 555                 560 


Lys Lys Cys Ala Thr Gly Asn Ala Leu Cys Gly Lys Leu Gln Cys Glu 
                565                 570                 575     


Asn Val Gln Glu Ile Pro Val Phe Gly Ile Val Pro Ala Ile Ile Gln 
            580                 585                 590         


Thr Pro Ser Arg Gly Thr Lys Cys Trp Gly Val Asp Phe Gln Leu Gly 
        595                 600                 605             


Ser Asp Val Pro Asp Pro Gly Met Val Asn Glu Gly Thr Lys Cys Gly 
    610                 615                 620                 


Ala Gly Lys Ile Cys Arg Asn Phe Gln Cys Val Asp Ala Ser Val Leu 
625                 630                 635                 640 


Asn Tyr Asp Cys Asp Val Gln Lys Lys Cys His Gly His Gly Lys 
                645                 650                 655 


<210>  473
<211>  610
<212>  PRT
<213>  Homo sapiens

<400>  473

Met Arg Gly Ala Ala Arg Leu Gly Arg Pro Gly Arg Ser Cys Leu Pro 
1               5                   10                  15      


Gly Ala Arg Gly Leu Arg Ala Pro Pro Pro Pro Pro Leu Leu Leu Leu 
            20                  25                  30          


Leu Ala Leu Leu Pro Leu Leu Pro Ala Pro Gly Ala Ala Ala Ala Pro 
        35                  40                  45              


Ala Pro Arg Pro Pro Glu Leu Gln Ser Ala Ser Ala Gly Pro Ser Val 
    50                  55                  60                  


Ser Leu Tyr Leu Ser Glu Asp Glu Val Arg Arg Leu Ile Gly Leu Asp 
65                  70                  75                  80  


Ala Glu Leu Tyr Tyr Val Arg Asn Asp Leu Ile Ser His Tyr Ala Leu 
                85                  90                  95      


Ser Phe Ser Leu Leu Val Pro Ser Glu Thr Asn Phe Leu His Phe Thr 
            100                 105                 110         


Trp His Ala Lys Ser Lys Val Glu Tyr Lys Leu Gly Phe Gln Val Asp 
        115                 120                 125             


Asn Val Leu Ala Met Asp Met Pro Gln Val Asn Ile Ser Val Gln Gly 
    130                 135                 140                 


Glu Val Pro Arg Thr Leu Ser Val Phe Arg Val Glu Leu Ser Cys Thr 
145                 150                 155                 160 


Gly Lys Val Asp Ser Glu Val Met Ile Leu Met Gln Leu Asn Leu Thr 
                165                 170                 175     


Val Asn Ser Ser Lys Asn Phe Thr Val Leu Asn Phe Lys Arg Arg Lys 
            180                 185                 190         


Met Cys Tyr Lys Lys Leu Glu Glu Val Lys Thr Ser Ala Leu Asp Lys 
        195                 200                 205             


Asn Thr Ser Arg Thr Ile Tyr Asp Pro Val His Ala Ala Pro Thr Thr 
    210                 215                 220                 


Ser Thr Arg Val Phe Tyr Ile Ser Val Gly Val Cys Cys Ala Val Ile 
225                 230                 235                 240 


Phe Leu Val Ala Ile Ile Leu Ala Val Leu His Leu His Ser Met Lys 
                245                 250                 255     


Arg Ile Glu Leu Asp Asp Ser Ile Ser Ala Ser Ser Ser Ser Gln Gly 
            260                 265                 270         


Leu Ser Gln Pro Ser Thr Gln Thr Thr Gln Tyr Leu Arg Ala Asp Thr 
        275                 280                 285             


Pro Asn Asn Ala Thr Pro Ile Thr Ser Ser Leu Gly Tyr Pro Thr Leu 
    290                 295                 300                 


Arg Ile Glu Lys Asn Asp Leu Arg Ser Val Thr Leu Leu Glu Ala Lys 
305                 310                 315                 320 


Gly Lys Val Lys Asp Ile Ala Ile Ser Arg Glu Arg Ile Thr Leu Lys 
                325                 330                 335     


Asp Val Leu Gln Glu Gly Thr Phe Gly Arg Ile Phe His Gly Ile Leu 
            340                 345                 350         


Ile Asp Glu Lys Asp Pro Asn Lys Glu Lys Gln Ala Phe Val Lys Thr 
        355                 360                 365             


Val Lys Asp Gln Ala Ser Glu Ile Gln Val Thr Met Met Leu Thr Glu 
    370                 375                 380                 


Ser Cys Lys Leu Arg Gly Leu His His Arg Asn Leu Leu Pro Ile Thr 
385                 390                 395                 400 


His Val Cys Ile Glu Glu Gly Glu Lys Pro Met Val Ile Leu Pro Tyr 
                405                 410                 415     


Met Asn Trp Gly Asn Leu Lys Leu Phe Leu Arg Gln Cys Lys Leu Val 
            420                 425                 430         


Glu Ala Asn Asn Pro Gln Ala Ile Ser Gln Gln Asp Leu Val His Met 
        435                 440                 445             


Ala Ile Gln Ile Ala Cys Gly Met Ser Tyr Leu Ala Arg Arg Glu Val 
    450                 455                 460                 


Ile His Lys Asp Leu Ala Ala Arg Asn Cys Val Ile Asp Asp Thr Leu 
465                 470                 475                 480 


Gln Val Lys Ile Thr Asp Asn Ala Leu Ser Arg Asp Leu Phe Pro Met 
                485                 490                 495     


Asp Tyr His Cys Leu Gly Asp Asn Glu Asn Arg Pro Val Arg Trp Met 
            500                 505                 510         


Ala Leu Glu Ser Leu Val Asn Asn Glu Phe Ser Ser Ala Ser Asp Val 
        515                 520                 525             


Trp Ala Phe Gly Val Thr Leu Trp Glu Leu Met Thr Leu Gly Gln Thr 
    530                 535                 540                 


Pro Tyr Val Asp Ile Asp Pro Phe Glu Met Ala Ala Tyr Leu Lys Asp 
545                 550                 555                 560 


Gly Tyr Arg Ile Ala Gln Pro Ile Asn Cys Pro Asp Glu Leu Phe Ala 
                565                 570                 575     


Val Met Ala Cys Cys Trp Ala Leu Asp Pro Glu Glu Arg Pro Lys Phe 
            580                 585                 590         


Gln Gln Leu Val Gln Cys Leu Thr Glu Phe His Ala Ala Leu Gly Ala 
        595                 600                 605             


Tyr Val 
    610 


<210>  474
<211>  1225
<212>  PRT
<213>  Homo sapiens

<400>  474

Met Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu 
1               5                   10                  15      


Arg His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu 
            20                  25                  30          


Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln 
        35                  40                  45              


Glu Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val 
    50                  55                  60                  


Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp 
65                  70                  75                  80  


Asn Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr 
                85                  90                  95      


Thr Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu 
            100                 105                 110         


Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn 
        115                 120                 125             


Pro Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His 
    130                 135                 140                 


Lys Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg 
145                 150                 155                 160 


Ala Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly 
                165                 170                 175     


Glu Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly 
            180                 185                 190         


Gly Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu 
        195                 200                 205             


Gln Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala 
    210                 215                 220                 


Cys Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala 
225                 230                 235                 240 


Leu Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu 
                245                 250                 255     


Gly Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn 
            260                 265                 270         


Tyr Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His 
        275                 280                 285             


Asn Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys 
    290                 295                 300                 


Ser Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu 
305                 310                 315                 320 


Arg Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly 
                325                 330                 335     


Cys Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp 
            340                 345                 350         


Gly Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln 
        355                 360                 365             


Val Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala 
    370                 375                 380                 


Trp Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val 
385                 390                 395                 400 


Ile Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln 
                405                 410                 415     


Gly Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly 
            420                 425                 430         


Ser Gly Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His 
        435                 440                 445             


Thr Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu 
    450                 455                 460                 


His Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala 
465                 470                 475                 480 


Cys His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr 
                485                 490                 495     


Gln Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu 
            500                 505                 510         


Glu Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg 
        515                 520                 525             


His Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val 
    530                 535                 540                 


Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr 
545                 550                 555                 560 


Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro 
                565                 570                 575     


Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala 
            580                 585                 590         


Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp 
        595                 600                 605             


Asp Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile 
    610                 615                 620                 


Ile Ser Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val 
625                 630                 635                 640 


Phe Gly Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr 
                645                 650                 655     


Met Arg Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro 
            660                 665                 670         


Ser Gly Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr 
        675                 680                 685             


Glu Leu Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val 
    690                 695                 700                 


Tyr Lys Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val 
705                 710                 715                 720 


Ala Ile Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu 
                725                 730                 735     


Ile Leu Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val 
            740                 745                 750         


Ser Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr 
        755                 760                 765             


Gln Leu Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg 
    770                 775                 780                 


Gly Arg Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala 
785                 790                 795                 800 


Lys Gly Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu 
                805                 810                 815     


Ala Ala Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr 
            820                 825                 830         


Asp Phe Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His 
        835                 840                 845             


Ala Asp Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile 
    850                 855                 860                 


Leu Arg Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val 
865                 870                 875                 880 


Thr Val Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile 
                885                 890                 895     


Pro Ala Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro 
            900                 905                 910         


Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys 
        915                 920                 925             


Trp Met Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser 
    930                 935                 940                 


Glu Phe Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln 
945                 950                 955                 960 


Asn Glu Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg 
                965                 970                 975     


Ser Leu Leu Glu Asp Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu 
            980                 985                 990         


Tyr Leu Val Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
        995                 1000                 1005             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1010                 1015                 1020             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1025                 1030                 1035             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1040                 1045                 1050             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1055                 1060                 1065             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1070                 1075                 1080             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1085                 1090                 1095             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1100                 1105                 1110             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1115                 1120                 1125             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1130                 1135                 1140             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1145                 1150                 1155             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1160                 1165                 1170             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1175                 1180                 1185             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1190                 1195                 1200             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1205                 1210                 1215             


Leu Gly  Leu Asp Val Pro Val  
    1220                 1225 


<210>  475
<211>  748
<212>  PRT
<213>  Homo sapiens

<400>  475

Met Gly Arg Ala Gly Ala Ala Ala Val Ile Pro Gly Leu Ala Leu Leu 
1               5                   10                  15      


Trp Ala Val Gly Leu Gly Ser Ala Ala Pro Ser Pro Pro Arg Leu Arg 
            20                  25                  30          


Leu Ser Phe Gln Glu Leu Gln Ala Trp His Gly Leu Gln Thr Phe Ser 
        35                  40                  45              


Leu Glu Arg Thr Cys Cys Tyr Gln Ala Leu Leu Val Asp Glu Glu Arg 
    50                  55                  60                  


Gly Arg Leu Phe Val Gly Ala Glu Asn His Val Ala Ser Leu Asn Leu 
65                  70                  75                  80  


Asp Asn Ile Ser Lys Arg Ala Lys Lys Leu Ala Trp Pro Ala Pro Val 
                85                  90                  95      


Glu Trp Arg Glu Glu Cys Asn Trp Ala Gly Lys Asp Ile Gly Thr Glu 
            100                 105                 110         


Cys Met Asn Phe Val Lys Leu Leu His Ala Tyr Asn Arg Thr His Leu 
        115                 120                 125             


Leu Ala Cys Gly Thr Gly Ala Phe His Pro Thr Cys Ala Phe Val Glu 
    130                 135                 140                 


Val Gly His Arg Ala Glu Glu Pro Val Leu Arg Leu Asp Pro Gly Arg 
145                 150                 155                 160 


Ile Glu Asp Gly Lys Gly Lys Ser Pro Tyr Asp Pro Arg His Arg Ala 
                165                 170                 175     


Ala Ser Val Leu Val Gly Glu Glu Leu Tyr Ser Gly Val Ala Ala Asp 
            180                 185                 190         


Leu Met Gly Arg Asp Phe Thr Ile Phe Arg Ser Leu Gly Gln Arg Pro 
        195                 200                 205             


Ser Leu Arg Thr Glu Pro His Asp Ser Arg Trp Leu Asn Glu Pro Lys 
    210                 215                 220                 


Phe Val Lys Val Phe Trp Ile Pro Glu Ser Glu Asn Pro Asp Asp Asp 
225                 230                 235                 240 


Lys Ile Tyr Phe Phe Phe Arg Glu Thr Ala Val Glu Ala Ala Pro Ala 
                245                 250                 255     


Leu Gly Arg Leu Ser Val Ser Arg Val Gly Gln Ile Cys Arg Asn Asp 
            260                 265                 270         


Val Gly Gly Gln Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys 
        275                 280                 285             


Ala Arg Leu Val Cys Ser Val Pro Gly Val Glu Gly Asp Thr His Phe 
    290                 295                 300                 


Asp Gln Leu Gln Asp Val Phe Leu Leu Ser Ser Arg Asp His Arg Thr 
305                 310                 315                 320 


Pro Leu Leu Tyr Ala Val Phe Ser Thr Ser Ser Ile Phe Gln Gly Ser 
                325                 330                 335     


Ala Val Cys Val Tyr Ser Met Asn Asp Val Arg Arg Ala Phe Leu Gly 
            340                 345                 350         


Pro Phe Ala His Lys Glu Gly Pro Met His Gln Trp Val Ser Tyr Gln 
        355                 360                 365             


Gly Arg Val Pro Tyr Pro Arg Pro Gly Met Cys Pro Ser Lys Thr Phe 
    370                 375                 380                 


Gly Thr Phe Ser Ser Thr Lys Asp Phe Pro Asp Asp Val Ile Gln Phe 
385                 390                 395                 400 


Ala Arg Asn His Pro Leu Met Tyr Asn Ser Val Leu Pro Thr Gly Gly 
                405                 410                 415     


Arg Pro Leu Phe Leu Gln Val Gly Ala Asn Tyr Thr Phe Thr Gln Ile 
            420                 425                 430         


Ala Ala Asp Arg Val Ala Ala Ala Asp Gly His Tyr Asp Val Leu Phe 
        435                 440                 445             


Ile Gly Thr Asp Val Gly Thr Val Leu Lys Val Ile Ser Val Pro Lys 
    450                 455                 460                 


Gly Ser Arg Pro Ser Ala Glu Gly Leu Leu Leu Glu Glu Leu His Val 
465                 470                 475                 480 


Phe Glu Asp Ser Ala Ala Val Thr Ser Met Gln Ile Ser Ser Lys Arg 
                485                 490                 495     


His Gln Leu Tyr Val Ala Ser Arg Ser Ala Val Ala Gln Ile Ala Leu 
            500                 505                 510         


His Arg Cys Ala Ala His Gly Arg Val Cys Thr Glu Cys Cys Leu Ala 
        515                 520                 525             


Arg Asp Pro Tyr Cys Ala Trp Asp Gly Val Ala Cys Thr Arg Phe Gln 
    530                 535                 540                 


Pro Ser Ala Lys Arg Arg Phe Arg Arg Gln Asp Val Arg Asn Gly Asp 
545                 550                 555                 560 


Pro Ser Thr Leu Cys Ser Gly Asp Ser Ser Arg Pro Ala Leu Leu Glu 
                565                 570                 575     


His Lys Val Phe Gly Val Glu Gly Ser Ser Ala Phe Leu Glu Cys Glu 
            580                 585                 590         


Pro Arg Ser Leu Gln Ala Arg Val Glu Trp Thr Phe Gln Arg Ala Gly 
        595                 600                 605             


Val Thr Ala His Thr Gln Val Leu Ala Glu Glu Arg Thr Glu Arg Thr 
    610                 615                 620                 


Ala Arg Gly Leu Leu Leu Arg Arg Leu Arg Arg Arg Asp Ser Gly Val 
625                 630                 635                 640 


Tyr Leu Cys Ala Ala Val Glu Gln Gly Phe Thr Gln Pro Leu Arg Arg 
                645                 650                 655     


Leu Ser Leu His Val Leu Ser Ala Thr Gln Ala Glu Arg Leu Ala Arg 
            660                 665                 670         


Ala Glu Glu Ala Ala Pro Ala Ala Pro Pro Gly Pro Lys Leu Trp Tyr 
        675                 680                 685             


Arg Asp Phe Leu Gln Leu Val Glu Pro Gly Gly Gly Gly Ser Ala Asn 
    690                 695                 700                 


Ser Leu Arg Met Cys Arg Pro Gln Pro Ala Leu Gln Ser Leu Pro Leu 
705                 710                 715                 720 


Glu Ser Arg Arg Lys Gly Arg Asn Arg Arg Thr His Ala Pro Glu Pro 
                725                 730                 735     


Arg Ala Glu Arg Gly Pro Arg Ser Ala Thr His Trp 
            740                 745             


<210>  476
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  476

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Gly Gln Phe Pro 
    130                 135                 140                 


Met Val Pro Ser Gly Leu Thr Pro Gln Pro Ala Gln Asp Trp Tyr Leu 
145                 150                 155                 160 


Leu Asp Asp Asp Pro Arg Leu Leu Thr Leu Ser Ala Ser Ser Lys Val 
                165                 170                 175     


Pro Val Thr Leu Ala Ala Val 
            180             


<210>  477
<211>  1258
<212>  PRT
<213>  Homo sapiens

<400>  477

Met Pro Glu Gln Glu Arg Gln Ile Thr Ala Arg Glu Gly Ala Ser Arg 
1               5                   10                  15      


Lys Ile Leu Ser Lys Leu Ser Leu Pro Thr Arg Ala Trp Glu Pro Ala 
            20                  25                  30          


Met Lys Lys Ser Phe Ala Phe Asp Asn Val Gly Tyr Glu Gly Gly Leu 
        35                  40                  45              


Asp Gly Leu Gly Pro Ser Ser Gln Val Ala Thr Ser Thr Val Arg Ile 
    50                  55                  60                  


Leu Gly Met Thr Cys Gln Ser Cys Val Lys Ser Ile Glu Asp Arg Ile 
65                  70                  75                  80  


Ser Asn Leu Lys Gly Ile Ile Ser Met Lys Val Ser Leu Glu Gln Gly 
                85                  90                  95      


Ser Ala Thr Val Lys Tyr Val Pro Ser Val Val Cys Leu Gln Gln Val 
            100                 105                 110         


Cys His Gln Ile Gly Asp Met Gly Phe Glu Ala Ser Ile Ala Glu Gly 
        115                 120                 125             


Lys Ala Ala Ser Trp Pro Ser Arg Ser Leu Pro Ala Gln Glu Ala Val 
    130                 135                 140                 


Val Lys Leu Arg Val Glu Gly Met Thr Cys Gln Ser Cys Val Ser Ser 
145                 150                 155                 160 


Ile Glu Gly Lys Val Arg Lys Leu Gln Gly Val Val Arg Val Lys Val 
                165                 170                 175     


Ser Leu Ser Asn Gln Glu Ala Val Ile Thr Tyr Gln Pro Tyr Leu Ile 
            180                 185                 190         


Gln Pro Glu Asp Leu Arg Asp His Val Asn Asp Met Gly Phe Glu Ala 
        195                 200                 205             


Ala Ile Lys Ser Lys Val Ala Pro Leu Ser Leu Gly Pro Ile Asp Ile 
    210                 215                 220                 


Glu Arg Leu Gln Ser Thr Asn Pro Lys Arg Pro Leu Ser Ser Ala Asn 
225                 230                 235                 240 


Gln Asn Phe Asn Asn Ser Glu Thr Leu Gly His Gln Gly Ser His Val 
                245                 250                 255     


Val Thr Leu Gln Leu Arg Ile Asp Gly Met His Cys Lys Ser Cys Val 
            260                 265                 270         


Leu Asn Ile Glu Glu Asn Ile Gly Gln Leu Leu Gly Val Gln Ser Ile 
        275                 280                 285             


Gln Val Ser Leu Glu Asn Lys Thr Ala Gln Val Lys Tyr Asp Pro Ser 
    290                 295                 300                 


Cys Thr Ser Pro Val Ala Leu Gln Arg Ala Ile Glu Ala Leu Pro Pro 
305                 310                 315                 320 


Gly Asn Phe Lys Val Ser Leu Pro Asp Gly Ala Glu Gly Ser Gly Thr 
                325                 330                 335     


Asp His Arg Ser Ser Ser Ser His Ser Pro Gly Ser Pro Pro Arg Asn 
            340                 345                 350         


Gln Val Gln Gly Thr Cys Ser Thr Thr Leu Ile Ala Ile Ala Gly Met 
        355                 360                 365             


Thr Cys Ala Ser Cys Val His Ser Ile Glu Gly Met Ile Ser Gln Leu 
    370                 375                 380                 


Glu Gly Val Gln Gln Ile Ser Val Ser Leu Ala Glu Gly Thr Ala Thr 
385                 390                 395                 400 


Val Leu Tyr Asn Pro Ser Val Ile Ser Pro Glu Glu Leu Arg Ala Ala 
                405                 410                 415     


Ile Glu Asp Met Gly Phe Glu Ala Ser Val Val Ser Glu Ser Cys Ser 
            420                 425                 430         


Thr Asn Pro Leu Gly Asn His Ser Ala Gly Asn Ser Met Val Gln Thr 
        435                 440                 445             


Thr Asp Gly Thr Pro Thr Ser Val Gln Glu Val Ala Pro His Thr Gly 
    450                 455                 460                 


Arg Leu Pro Ala Asn His Ala Pro Asp Ile Leu Ala Lys Ser Pro Gln 
465                 470                 475                 480 


Ser Thr Arg Ala Val Ala Pro Gln Lys Cys Phe Leu Gln Ile Lys Gly 
                485                 490                 495     


Met Thr Cys Ala Ser Cys Val Ser Asn Ile Glu Arg Asn Leu Gln Lys 
            500                 505                 510         


Glu Ala Gly Val Leu Ser Val Leu Val Ala Leu Met Ala Gly Lys Ala 
        515                 520                 525             


Glu Ile Lys Tyr Asp Pro Glu Val Ile Gln Pro Leu Glu Ile Ala Gln 
    530                 535                 540                 


Phe Ile Gln Asp Leu Gly Phe Glu Ala Ala Val Met Glu Asp Tyr Ala 
545                 550                 555                 560 


Gly Ser Asp Gly Asn Ile Glu Leu Thr Ile Thr Gly Met Thr Cys Ala 
                565                 570                 575     


Ser Cys Val His Asn Ile Glu Ser Lys Leu Thr Arg Thr Asn Gly Ile 
            580                 585                 590         


Thr Tyr Ala Ser Val Ala Leu Ala Thr Ser Lys Ala Leu Val Lys Phe 
        595                 600                 605             


Asp Pro Glu Ile Ile Gly Pro Arg Asp Ile Ile Lys Ile Ile Glu Ser 
    610                 615                 620                 


Lys Thr Ser Glu Ala Leu Ala Lys Leu Met Ser Leu Gln Ala Thr Glu 
625                 630                 635                 640 


Ala Thr Val Val Thr Leu Gly Glu Asp Asn Leu Ile Ile Arg Glu Glu 
                645                 650                 655     


Gln Val Pro Met Glu Leu Val Gln Arg Gly Asp Ile Val Lys Val Val 
            660                 665                 670         


Pro Gly Gly Lys Phe Pro Val Asp Gly Lys Val Leu Glu Gly Asn Thr 
        675                 680                 685             


Met Ala Asp Glu Ser Leu Ile Thr Gly Glu Ala Met Pro Val Thr Lys 
    690                 695                 700                 


Lys Pro Gly Ser Thr Val Ile Ala Gly Ser Ile Asn Ala His Gly Ser 
705                 710                 715                 720 


Val Leu Ile Lys Ala Thr His Val Gly Asn Asp Thr Thr Leu Ala Gln 
                725                 730                 735     


Ile Val Lys Leu Val Glu Glu Ala Gln Met Ser Lys Asn Pro Asn Lys 
            740                 745                 750         


His Ile Ser Gln Thr Glu Val Ile Ile Arg Phe Ala Phe Gln Thr Ser 
        755                 760                 765             


Ile Thr Val Leu Cys Ile Ala Cys Pro Cys Ser Leu Gly Leu Ala Thr 
    770                 775                 780                 


Pro Thr Ala Val Met Val Gly Thr Gly Val Ala Ala Gln Asn Gly Ile 
785                 790                 795                 800 


Leu Ile Lys Gly Gly Lys Pro Leu Glu Met Ala His Lys Ile Lys Thr 
                805                 810                 815     


Val Met Phe Asp Lys Thr Gly Thr Ile Thr His Gly Val Pro Arg Val 
            820                 825                 830         


Met Arg Val Leu Leu Leu Gly Asp Val Ala Thr Leu Pro Leu Arg Lys 
        835                 840                 845             


Val Leu Ala Val Val Gly Thr Ala Glu Ala Ser Ser Glu His Pro Leu 
    850                 855                 860                 


Gly Val Ala Val Thr Lys Tyr Cys Lys Glu Glu Leu Gly Thr Glu Thr 
865                 870                 875                 880 


Leu Gly Tyr Cys Thr Asp Phe Gln Ala Val Pro Gly Cys Gly Ile Gly 
                885                 890                 895     


Cys Lys Val Ser Asn Val Glu Gly Ile Leu Ala His Ser Glu Arg Pro 
            900                 905                 910         


Leu Ser Ala Pro Ala Ser His Leu Asn Glu Ala Gly Ser Leu Pro Ala 
        915                 920                 925             


Glu Lys Asp Ala Val Pro Gln Thr Phe Ser Val Leu Ile Gly Asn Arg 
    930                 935                 940                 


Glu Trp Leu Arg Arg Asn Gly Leu Thr Ile Ser Ser Asp Val Ser Asp 
945                 950                 955                 960 


Ala Met Thr Asp His Glu Met Lys Gly Gln Thr Ala Ile Leu Val Ala 
                965                 970                 975     


Ile Asp Gly Val Leu Cys Gly Met Ile Ala Ile Ala Asp Ala Val Lys 
            980                 985                 990         


Gln Glu Ala Ala Leu Ala Val His  Thr Leu Gln Ser Met  Gly Val Asp 
        995                 1000                 1005             


Val Val  Leu Ile Thr Gly Asp  Asn Arg Lys Thr Ala  Arg Ala Ile 
    1010                 1015                 1020             


Ala Thr  Gln Val Gly Ile Asn  Lys Val Phe Ala Glu  Val Leu Pro 
    1025                 1030                 1035             


Ser His  Lys Val Ala Lys Val  Gln Glu Leu Gln Asn  Lys Gly Lys 
    1040                 1045                 1050             


Lys Val  Ala Met Val Gly Asp  Gly Val Asn Asp Ser  Pro Ala Leu 
    1055                 1060                 1065             


Ala Gln  Ala Asp Met Gly Val  Ala Ile Gly Thr Gly  Thr Asp Val 
    1070                 1075                 1080             


Ala Ile  Glu Ala Ala Asp Val  Val Leu Ile Arg Asn  Asp Leu Leu 
    1085                 1090                 1095             


Asp Val  Val Ala Ser Ile His  Leu Ser Lys Arg Thr  Val Arg Arg 
    1100                 1105                 1110             


Ile Arg  Ile Asn Leu Val Leu  Ala Leu Ile Tyr Asn  Leu Val Gly 
    1115                 1120                 1125             


Ile Pro  Ile Ala Ala Gly Val  Phe Met Pro Ile Gly  Ile Val Leu 
    1130                 1135                 1140             


Gln Pro  Trp Met Gly Ser Ala  Ala Met Ala Ala Ser  Ser Val Ser 
    1145                 1150                 1155             


Val Val  Leu Ser Ser Leu Gln  Leu Lys Cys Tyr Lys  Lys Pro Asp 
    1160                 1165                 1170             


Leu Glu  Arg Tyr Glu Ala Gln  Ala His Gly His Met  Lys Pro Leu 
    1175                 1180                 1185             


Thr Ala  Ser Gln Val Ser Val  His Ile Gly Met Asp  Asp Arg Trp 
    1190                 1195                 1200             


Arg Asp  Ser Pro Arg Ala Thr  Pro Trp Asp Gln Val  Ser Tyr Val 
    1205                 1210                 1215             


Ser Gln  Val Ser Leu Ser Ser  Leu Thr Ser Asp Lys  Pro Ser Arg 
    1220                 1225                 1230             


His Ser  Ala Ala Ala Asp Asp  Asp Gly Asp Lys Trp  Ser Leu Leu 
    1235                 1240                 1245             


Leu Asn  Gly Arg Asp Glu Glu  Gln Tyr Ile 
    1250                 1255             


<210>  478
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  478

Met Ala Arg Ser Leu Cys Pro Gly Ala Trp Leu Arg Lys Pro Tyr Tyr 
1               5                   10                  15      


Leu Gln Ala Arg Phe Ser Tyr Val Arg Met Lys Tyr Leu Phe Phe Ser 
            20                  25                  30          


Trp Leu Val Val Phe Val Gly Ser Trp Ile Ile Tyr Val Gln Tyr Ser 
        35                  40                  45              


Thr Tyr Thr Glu Leu Cys Arg Gly Lys Asp Cys Lys Lys Ile Ile Cys 
    50                  55                  60                  


Asp Lys Tyr Lys Thr Gly Val Ile Asp Gly Pro Ala Cys Asn Ser Leu 
65                  70                  75                  80  


Cys Val Thr Glu Thr Leu Tyr Phe Gly Lys Cys Leu Ser Thr Lys Pro 
                85                  90                  95      


Asn Asn Gln Met Tyr Leu Gly Ile Trp Asp Asn Leu Pro Gly Val Val 
            100                 105                 110         


Lys Cys Gln Met Glu Gln Ala Leu His Leu Asp Phe Gly Thr Glu Leu 
        115                 120                 125             


Glu Pro Arg Lys Glu Ile Val Leu Phe Asp Lys Pro Thr Arg Gly Thr 
    130                 135                 140                 


Thr Val Gln Lys Phe Lys Glu Met Val Tyr Ser Leu Phe Lys Ala Lys 
145                 150                 155                 160 


Leu Gly Asp Gln Gly Asn Leu Ser Glu Leu Val Asn Leu Ile Leu Thr 
                165                 170                 175     


Val Ala Asp Gly Asp Lys Asp Gly Gln Val Ser Leu Gly Glu Ala Lys 
            180                 185                 190         


Ser Ala Trp Ala Leu Leu Gln Leu Asn Glu Phe Leu Leu Met Val Ile 
        195                 200                 205             


Leu Gln Asp Lys Glu His Thr Pro Lys Leu Met Gly Phe Cys Gly Asp 
    210                 215                 220                 


Leu Tyr Val Met Glu Ser Val Glu Tyr Thr Ser Leu Tyr Gly Ile Ser 
225                 230                 235                 240 


Leu Pro Trp Val Ile Glu Leu Phe Ile Pro Ser Gly Phe Arg Arg Ser 
                245                 250                 255     


Met Asp Gln Leu Phe Thr Pro Ser Trp Pro Arg Lys Ala Lys Ile Ala 
            260                 265                 270         


Ile Gly Leu Leu Glu Phe Val Glu Asp Val Phe His Gly Pro Tyr Gly 
        275                 280                 285             


Asn Phe Leu Met Cys Asp Thr Ser Ala Lys Asn Leu Gly Tyr Asn Asp 
    290                 295                 300                 


Lys Tyr Asp Leu Lys Met Val Asp Met Arg Lys Ile Val Pro Glu Thr 
305                 310                 315                 320 


Asn Leu Lys Glu Leu Ile Lys Asp Arg His Cys Glu Ser Asp Leu Asp 
                325                 330                 335     


Cys Val Tyr Gly Thr Asp Cys Arg Thr Ser Cys Asp Gln Ser Thr Met 
            340                 345                 350         


Lys Cys Thr Ser Glu Val Ile Gln Pro Asn Leu Ala Lys Ala Cys Gln 
        355                 360                 365             


Leu Leu Lys Asp Tyr Leu Leu Arg Gly Ala Pro Ser Glu Ile Arg Glu 
    370                 375                 380                 


Glu Leu Glu Lys Gln Leu Tyr Ser Cys Ile Ala Leu Lys Val Thr Ala 
385                 390                 395                 400 


Asn Gln Met Glu Met Glu His Ser Leu Ile Leu Asn Asn Leu Lys Thr 
                405                 410                 415     


Leu Leu Trp Lys Lys Ile Ser Tyr Thr Asn Asp Ser 
            420                 425             


<210>  479
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  479

Met Ala Thr Glu Ile Gly Ser Pro Pro Arg Phe Phe His Met Pro Arg 
1               5                   10                  15      


Phe Gln His Gln Ala Pro Arg Gln Leu Phe Tyr Lys Arg Pro Asp Phe 
            20                  25                  30          


Ala Gln Gln Gln Ala Met Gln Gln Leu Thr Phe Asp Gly Lys Arg Met 
        35                  40                  45              


Arg Lys Ala Val Asn Arg Lys Thr Ile Asp Tyr Asn Pro Ser Val Ile 
    50                  55                  60                  


Lys Tyr Leu Glu Asn Arg Ile Trp Gln Arg Asp Gln Arg Asp Met Arg 
65                  70                  75                  80  


Ala Ile Gln Pro Asp Ala Gly Tyr Tyr Asn Asp Leu Val Pro Pro Ile 
                85                  90                  95      


Gly Met Leu Asn Asn Pro Met Asn Ala Val Thr Thr Lys Phe Val Arg 
            100                 105                 110         


Thr Ser Thr Asn Lys Val Lys Cys Pro Val Phe Val Val Arg Trp Thr 
        115                 120                 125             


Pro Glu Gly Arg Arg Leu Val Thr Gly Ala Ser Ser Gly Glu Phe Thr 
    130                 135                 140                 


Leu Trp Asn Gly Leu Thr Phe Asn Phe Glu Thr Ile Leu Gln Ala His 
145                 150                 155                 160 


Asp Ser Pro Val Arg Ala Met Thr Trp Ser His Asn Asp Met Trp Met 
                165                 170                 175     


Leu Thr Ala Asp His Gly Gly Tyr Val Lys Tyr Trp Gln Ser Asn Met 
            180                 185                 190         


Asn Asn Val Lys Met Phe Gln Ala His Lys Glu Ala Ile Arg Glu Ala 
        195                 200                 205             


Arg Phe Ile His Asn Ile Pro Phe Ser Val Val Pro Ile Val Met Val 
    210                 215                 220                 


Lys Leu Phe Ser Lys Cys Ile Leu Gly Ala Glu Met His Gly Leu Cys 
225                 230                 235                 240 


Gln Phe Leu Gly Asn Phe Leu His Pro Ile Asn Thr Ile Phe Phe Phe 
                245                 250                 255     


Val Phe Thr His Ser Pro Phe Cys Trp His Leu Ser Glu Val Val Leu 
            260                 265                 270         


Ser Arg Tyr Gln Pro Leu Gln Tyr Val Arg Asp Val Leu Ser Ala Ala 
        275                 280                 285             


Phe Cys Thr Gly Phe Leu Phe Ser Phe Met Ile Asn Asn Val Tyr Thr 
    290                 295                 300                 


Leu Phe Leu Phe Ile Ile Tyr Cys Val Arg Gln Glu Tyr Phe Ile Pro 
305                 310                 315                 320 


Asn Lys Glu Phe Ser Leu 
                325     


<210>  480
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  480

Met Ala Thr Glu Ile Gly Ser Pro Pro Arg Phe Phe His Met Pro Arg 
1               5                   10                  15      


Phe Gln His Gln Ala Pro Arg Gln Leu Phe Tyr Lys Arg Pro Asp Phe 
            20                  25                  30          


Ala Gln Gln Gln Ala Met Gln Gln Leu Thr Phe Asp Gly Lys Arg Met 
        35                  40                  45              


Arg Lys Ala Val Asn Arg Lys Thr Ile Asp Tyr Asn Pro Ser Val Ile 
    50                  55                  60                  


Lys Tyr Leu Glu Asn Arg Ile Trp Gln Arg Asp Gln Arg Asp Met Arg 
65                  70                  75                  80  


Ala Ile Gln Pro Asp Ala Gly Tyr Tyr Asn Asp Leu Val Pro Pro Ile 
                85                  90                  95      


Gly Met Leu Asn Asn Pro Met Asn Ala Val Thr Thr Lys Phe Val Arg 
            100                 105                 110         


Thr Ser Thr Asn Lys Val Lys Cys Pro Val Phe Val Val Arg Trp Thr 
        115                 120                 125             


Pro Glu Gly Arg Arg Leu Val Thr Gly Ala Ser Ser Gly Glu Phe Thr 
    130                 135                 140                 


Leu Trp Asn Gly Leu Thr Phe Asn Phe Glu Thr Ile Leu Gln Ala His 
145                 150                 155                 160 


Asp Ser Pro Val Arg Ala Met Thr Trp Ser His Asn Asp Met Trp Met 
                165                 170                 175     


Leu Thr Ala Asp His Gly Gly Tyr Val Lys Tyr Trp Gln Ser Asn Met 
            180                 185                 190         


Asn Asn Val Lys Met Phe Gln Ala His Lys Glu Ala Ile Arg Glu Ala 
        195                 200                 205             


Ser Phe Ser Pro Thr Asp Asn Lys Phe Ala Thr Cys Ser Asp Asp Gly 
    210                 215                 220                 


Thr Val Arg Ile Trp Asp Phe Leu Arg Cys His Glu Glu Arg Ile Leu 
225                 230                 235                 240 


Arg Asp Thr Cys Phe His His Cys Arg Cys Tyr Phe Leu Ser Val Lys 
                245                 250                 255     


Arg 
    


<210>  481
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  481

Met Pro Gly Ala Glu Asp Asp Val Val Thr Pro Gly Thr Ser Glu Asp 
1               5                   10                  15      


Arg Tyr Lys Ser Gly Leu Thr Thr Leu Val Ala Thr Ser Val Asn Ser 
            20                  25                  30          


Val Thr Gly Ile Arg Ile Glu Asp Leu Pro Thr Ser Glu Ser Thr Val 
        35                  40                  45              


His Ala Gln Glu Gln Ser Pro Ser Ala Thr Ala Ser Asn Val Ala Thr 
    50                  55                  60                  


Ser His Ser Thr Glu Lys Val Asp Gly Asp Thr Gln Thr Thr Val Glu 
65                  70                  75                  80  


Lys Asp Gly Leu Ser Thr Val Thr Leu Val Gly Ile Ile Val Gly Val 
                85                  90                  95      


Leu Leu Ala Ile Gly Phe Ile Gly Ala Ile Ile Val Val Val Met Arg 
            100                 105                 110         


Lys Met Ser Gly Arg Tyr Ser Pro 
        115                 120 


<210>  482
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  482

Met Pro Gly Ala Glu Asp Asp Val Val Thr Pro Gly Thr Ser Glu Asp 
1               5                   10                  15      


Arg Tyr Lys Ser Gly Leu Thr Thr Leu Val Ala Thr Ser Val Asn Ser 
            20                  25                  30          


Val Thr Gly Ile Arg Ile Glu Asp Leu Pro Thr Ser Glu Ser Thr Val 
        35                  40                  45              


His Ala Gln Glu Gln Ser Pro Ser Ala Thr Ala Ser Asn Val Ala Thr 
    50                  55                  60                  


Ser His Ser Thr Glu Lys Val Asp Gly Asp Thr Gln Thr Thr Val Glu 
65                  70                  75                  80  


Lys Asp Gly Leu Ser Thr Val Thr Leu Val Gly Ile Ile Val Gly Val 
                85                  90                  95      


Leu Leu Ala Ile Gly Phe Ile Gly Ala Ile Ile Val Val Val Met Arg 
            100                 105                 110         


Lys Met Ser Gly Arg Pro 
        115             


<210>  483
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  483

Met Asn Asn Ser Thr Asn Ser Ser Asn Asn Ser Leu Ala Leu Thr Ser 
1               5                   10                  15      


Pro Tyr Lys Thr Phe Glu Val Val Phe Ile Val Leu Val Ala Gly Ser 
            20                  25                  30          


Leu Ser Leu Val Thr Ile Ile Gly Asn Ile Leu Val Met Val Ser Ile 
        35                  40                  45              


Lys Val Asn Arg His Leu Gln Thr Val Asn Asn Tyr Phe Leu Phe Ser 
    50                  55                  60                  


Leu Ala Cys Ala Asp Leu Ile Ile Gly Val Phe Ser Met Asn Leu Tyr 
65                  70                  75                  80  


Thr Leu Tyr Thr Val Ile Gly Tyr Trp Pro Leu Gly Pro Val Val Cys 
                85                  90                  95      


Asp Leu Trp Leu Ala Leu Asp Tyr Val Val Ser Asn Ala Ser Val Met 
            100                 105                 110         


Asn Leu Leu Ile Ile Ser Phe Asp Arg Tyr Phe Cys Val Thr Lys Pro 
        115                 120                 125             


Leu Thr Tyr Pro Val Lys Arg Thr Thr Lys Met Ala Gly Met Met Ile 
    130                 135                 140                 


Ala Ala Ala Trp Val Leu Ser Phe Ile Leu Trp Ala Pro Ala Ile Leu 
145                 150                 155                 160 


Phe Trp Gln Phe Ile Val Gly Val Arg Thr Val Glu Asp Gly Glu Cys 
                165                 170                 175     


Tyr Ile Gln Phe Phe Ser Asn Ala Ala Val Thr Phe Gly Thr Ala Ile 
            180                 185                 190         


Ala Ala Phe Tyr Leu Pro Val Ile Ile Met Thr Val Leu Tyr Trp His 
        195                 200                 205             


Ile Ser Arg Ala Ser Lys Ser Arg Ile Lys Lys Asp Lys Lys Glu Pro 
    210                 215                 220                 


Val Ala Asn Gln Asp Pro Val Ser Pro Ser Leu Val Gln Gly Arg Ile 
225                 230                 235                 240 


Val Lys Pro Asn Asn Asn Asn Met Pro Ser Ser Asp Asp Gly Leu Glu 
                245                 250                 255     


His Asn Lys Ile Gln Asn Gly Lys Ala Pro Arg Asp Pro Val Thr Glu 
            260                 265                 270         


Asn Cys Val Gln Gly Glu Glu Lys Glu Ser Ser Asn Asp Ser Thr Ser 
        275                 280                 285             


Val Ser Ala Val Ala Ser Asn Met Arg Asp Asp Glu Ile Thr Gln Asp 
    290                 295                 300                 


Glu Asn Thr Val Ser Thr Ser Leu Gly His Ser Lys Asp Glu Asn Ser 
305                 310                 315                 320 


Lys Gln Thr Cys Ile Arg Ile Gly Thr Lys Thr Pro Lys Ser Asp Ser 
                325                 330                 335     


Cys Thr Pro Thr Asn Thr Thr Val Glu Val Val Gly Ser Ser Gly Gln 
            340                 345                 350         


Asn Gly Asp Glu Lys Gln Asn Ile Val Ala Arg Lys Ile Val Lys Met 
        355                 360                 365             


Thr Lys Gln Pro Ala Lys Lys Lys Pro Pro Pro Ser Arg Glu Lys Lys 
    370                 375                 380                 


Val Thr Arg Thr Ile Leu Ala Ile Leu Leu Ala Phe Ile Ile Thr Trp 
385                 390                 395                 400 


Ala Pro Tyr Asn Val Met Val Leu Ile Asn Thr Phe Cys Ala Pro Cys 
                405                 410                 415     


Ile Pro Asn Thr Val Trp Thr Ile Gly Tyr Trp Leu Cys Tyr Ile Asn 
            420                 425                 430         


Ser Thr Ile Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys 
        435                 440                 445             


Lys Thr Phe Lys His Leu Leu Met Cys His Tyr Lys Asn Ile Gly Ala 
    450                 455                 460                 


Thr Arg 
465     


<210>  484
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  484

Met Asn Asn Ser Thr Asn Ser Ser Asn Asn Ser Leu Ala Leu Thr Ser 
1               5                   10                  15      


Pro Tyr Lys Thr Phe Glu Val Val Phe Ile Val Leu Val Ala Gly Ser 
            20                  25                  30          


Leu Ser Leu Val Thr Ile Ile Gly Asn Ile Leu Val Met Val Ser Ile 
        35                  40                  45              


Lys Val Asn Arg His Leu Gln Thr Val Asn Asn Tyr Phe Leu Phe Ser 
    50                  55                  60                  


Leu Ala Cys Ala Asp Leu Ile Ile Gly Val Phe Ser Met Asn Leu Tyr 
65                  70                  75                  80  


Thr Leu Tyr Thr Val Ile Gly Tyr Trp Pro Leu Gly Pro Val Val Cys 
                85                  90                  95      


Asp Leu Trp Leu Ala Leu Asp Tyr Val Val Ser Asn Ala Ser Val Met 
            100                 105                 110         


Asn Leu Leu Ile Ile Ser Phe Asp Arg Tyr Phe Cys Val Thr Lys Pro 
        115                 120                 125             


Leu Thr Tyr Pro Val Lys Arg Thr Thr Lys Met Ala Gly Met Met Ile 
    130                 135                 140                 


Ala Ala Ala Trp Val Leu Ser Phe Ile Leu Trp Ala Pro Ala Ile Leu 
145                 150                 155                 160 


Phe Trp Gln Phe Ile Val Gly Val Arg Thr Val Glu Asp Gly Glu Cys 
                165                 170                 175     


Tyr Ile Gln Phe Phe Ser Asn Ala Ala Val Thr Phe Gly Thr Ala Ile 
            180                 185                 190         


Ala Ala Phe Tyr Leu Pro Val Ile Ile Met Thr Val Leu Tyr Trp His 
        195                 200                 205             


Ile Ser Arg Ala Ser Lys Ser Arg Ile Lys Lys Asp Lys Lys Glu Pro 
    210                 215                 220                 


Val Ala Asn Gln Asp Pro Val Ser Pro Ser Leu Val Gln Gly Arg Ile 
225                 230                 235                 240 


Val Lys Pro Asn Asn Asn Asn Met Pro Ser Ser Asp Asp Gly Leu Glu 
                245                 250                 255     


His Asn Lys Ile Gln Asn Gly Lys Ala Pro Arg Asp Pro Val Thr Glu 
            260                 265                 270         


Asn Cys Val Gln Gly Glu Glu Lys Glu Ser Ser Asn Asp Ser Thr Ser 
        275                 280                 285             


Val Ser Ala Val Ala Ser Asn Met Arg Asp Asp Glu Ile Thr Gln Asp 
    290                 295                 300                 


Glu Asn Thr Val Ser Thr Ser Leu Gly His Ser Lys Asp Glu Asn Ser 
305                 310                 315                 320 


Lys Gln Thr Cys Ile Arg Ile Gly Thr Lys Thr Pro Lys Ser Asp Ser 
                325                 330                 335     


Cys Thr Pro Thr Asn Thr Thr Val Glu Val Val Gly Ser Ser Gly Gln 
            340                 345                 350         


Asn Gly Asp Glu Lys Gln Asn Ile Val Ala Arg Lys Ile Val Lys Met 
        355                 360                 365             


Thr Lys Gln Pro Ala Lys Lys Lys Pro Pro Pro Ser Arg Glu Lys Lys 
    370                 375                 380                 


Val Thr Arg Thr Ile Leu Ala Ile Leu Leu Ala Phe Ile Ile Thr Trp 
385                 390                 395                 400 


Ala Pro Tyr Asn Val Met Val Leu Ile Asn Thr Phe Cys Ala Pro Cys 
                405                 410                 415     


Ile Pro Asn Thr Val Trp Thr Ile Gly Tyr Trp Leu Cys Tyr Ile Asn 
            420                 425                 430         


Ser Thr Ile Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys 
        435                 440                 445             


Lys Thr Phe Lys His Leu Leu Met Cys His Tyr Lys Asn Ile Gly Ala 
    450                 455                 460                 


Thr Arg 
465     


<210>  485
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  485

Met Asn Asn Ser Thr Asn Ser Ser Asn Asn Ser Leu Ala Leu Thr Ser 
1               5                   10                  15      


Pro Tyr Lys Thr Phe Glu Val Val Phe Ile Val Leu Val Ala Gly Ser 
            20                  25                  30          


Leu Ser Leu Val Thr Ile Ile Gly Asn Ile Leu Val Met Val Ser Ile 
        35                  40                  45              


Lys Val Asn Arg His Leu Gln Thr Val Asn Asn Tyr Phe Leu Phe Ser 
    50                  55                  60                  


Leu Ala Cys Ala Asp Leu Ile Ile Gly Val Phe Ser Met Asn Leu Tyr 
65                  70                  75                  80  


Thr Leu Tyr Thr Val Ile Gly Tyr Trp Pro Leu Gly Pro Val Val Cys 
                85                  90                  95      


Asp Leu Trp Leu Ala Leu Asp Tyr Val Val Ser Asn Ala Ser Val Met 
            100                 105                 110         


Asn Leu Leu Ile Ile Ser Phe Asp Arg Tyr Phe Cys Val Thr Lys Pro 
        115                 120                 125             


Leu Thr Tyr Pro Val Lys Arg Thr Thr Lys Met Ala Gly Met Met Ile 
    130                 135                 140                 


Ala Ala Ala Trp Val Leu Ser Phe Ile Leu Trp Ala Pro Ala Ile Leu 
145                 150                 155                 160 


Phe Trp Gln Phe Ile Val Gly Val Arg Thr Val Glu Asp Gly Glu Cys 
                165                 170                 175     


Tyr Ile Gln Phe Phe Ser Asn Ala Ala Val Thr Phe Gly Thr Ala Ile 
            180                 185                 190         


Ala Ala Phe Tyr Leu Pro Val Ile Ile Met Thr Val Leu Tyr Trp His 
        195                 200                 205             


Ile Ser Arg Ala Ser Lys Ser Arg Ile Lys Lys Asp Lys Lys Glu Pro 
    210                 215                 220                 


Val Ala Asn Gln Asp Pro Val Ser Pro Ser Leu Val Gln Gly Arg Ile 
225                 230                 235                 240 


Val Lys Pro Asn Asn Asn Asn Met Pro Ser Ser Asp Asp Gly Leu Glu 
                245                 250                 255     


His Asn Lys Ile Gln Asn Gly Lys Ala Pro Arg Asp Pro Val Thr Glu 
            260                 265                 270         


Asn Cys Val Gln Gly Glu Glu Lys Glu Ser Ser Asn Asp Ser Thr Ser 
        275                 280                 285             


Val Ser Ala Val Ala Ser Asn Met Arg Asp Asp Glu Ile Thr Gln Asp 
    290                 295                 300                 


Glu Asn Thr Val Ser Thr Ser Leu Gly His Ser Lys Asp Glu Asn Ser 
305                 310                 315                 320 


Lys Gln Thr Cys Ile Arg Ile Gly Thr Lys Thr Pro Lys Ser Asp Ser 
                325                 330                 335     


Cys Thr Pro Thr Asn Thr Thr Val Glu Val Val Gly Ser Ser Gly Gln 
            340                 345                 350         


Asn Gly Asp Glu Lys Gln Asn Ile Val Ala Arg Lys Ile Val Lys Met 
        355                 360                 365             


Thr Lys Gln Pro Ala Lys Lys Lys Pro Pro Pro Ser Arg Glu Lys Lys 
    370                 375                 380                 


Val Thr Arg Thr Ile Leu Ala Ile Leu Leu Ala Phe Ile Ile Thr Trp 
385                 390                 395                 400 


Ala Pro Tyr Asn Val Met Val Leu Ile Asn Thr Phe Cys Ala Pro Cys 
                405                 410                 415     


Ile Pro Asn Thr Val Trp Thr Ile Gly Tyr Trp Leu Cys Tyr Ile Asn 
            420                 425                 430         


Ser Thr Ile Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys 
        435                 440                 445             


Lys Thr Phe Lys His Leu Leu Met Cys His Tyr Lys Asn Ile Gly Ala 
    450                 455                 460                 


Thr Arg 
465     


<210>  486
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  486

Met Asn Asn Ser Thr Asn Ser Ser Asn Asn Ser Leu Ala Leu Thr Ser 
1               5                   10                  15      


Pro Tyr Lys Thr Phe Glu Val Val Phe Ile Val Leu Val Ala Gly Ser 
            20                  25                  30          


Leu Ser Leu Val Thr Ile Ile Gly Asn Ile Leu Val Met Val Ser Ile 
        35                  40                  45              


Lys Val Asn Arg His Leu Gln Thr Val Asn Asn Tyr Phe Leu Phe Ser 
    50                  55                  60                  


Leu Ala Cys Ala Asp Leu Ile Ile Gly Val Phe Ser Met Asn Leu Tyr 
65                  70                  75                  80  


Thr Leu Tyr Thr Val Ile Gly Tyr Trp Pro Leu Gly Pro Val Val Cys 
                85                  90                  95      


Asp Leu Trp Leu Ala Leu Asp Tyr Val Val Ser Asn Ala Ser Val Met 
            100                 105                 110         


Asn Leu Leu Ile Ile Ser Phe Asp Arg Tyr Phe Cys Val Thr Lys Pro 
        115                 120                 125             


Leu Thr Tyr Pro Val Lys Arg Thr Thr Lys Met Ala Gly Met Met Ile 
    130                 135                 140                 


Ala Ala Ala Trp Val Leu Ser Phe Ile Leu Trp Ala Pro Ala Ile Leu 
145                 150                 155                 160 


Phe Trp Gln Phe Ile Val Gly Val Arg Thr Val Glu Asp Gly Glu Cys 
                165                 170                 175     


Tyr Ile Gln Phe Phe Ser Asn Ala Ala Val Thr Phe Gly Thr Ala Ile 
            180                 185                 190         


Ala Ala Phe Tyr Leu Pro Val Ile Ile Met Thr Val Leu Tyr Trp His 
        195                 200                 205             


Ile Ser Arg Ala Ser Lys Ser Arg Ile Lys Lys Asp Lys Lys Glu Pro 
    210                 215                 220                 


Val Ala Asn Gln Asp Pro Val Ser Pro Ser Leu Val Gln Gly Arg Ile 
225                 230                 235                 240 


Val Lys Pro Asn Asn Asn Asn Met Pro Ser Ser Asp Asp Gly Leu Glu 
                245                 250                 255     


His Asn Lys Ile Gln Asn Gly Lys Ala Pro Arg Asp Pro Val Thr Glu 
            260                 265                 270         


Asn Cys Val Gln Gly Glu Glu Lys Glu Ser Ser Asn Asp Ser Thr Ser 
        275                 280                 285             


Val Ser Ala Val Ala Ser Asn Met Arg Asp Asp Glu Ile Thr Gln Asp 
    290                 295                 300                 


Glu Asn Thr Val Ser Thr Ser Leu Gly His Ser Lys Asp Glu Asn Ser 
305                 310                 315                 320 


Lys Gln Thr Cys Ile Arg Ile Gly Thr Lys Thr Pro Lys Ser Asp Ser 
                325                 330                 335     


Cys Thr Pro Thr Asn Thr Thr Val Glu Val Val Gly Ser Ser Gly Gln 
            340                 345                 350         


Asn Gly Asp Glu Lys Gln Asn Ile Val Ala Arg Lys Ile Val Lys Met 
        355                 360                 365             


Thr Lys Gln Pro Ala Lys Lys Lys Pro Pro Pro Ser Arg Glu Lys Lys 
    370                 375                 380                 


Val Thr Arg Thr Ile Leu Ala Ile Leu Leu Ala Phe Ile Ile Thr Trp 
385                 390                 395                 400 


Ala Pro Tyr Asn Val Met Val Leu Ile Asn Thr Phe Cys Ala Pro Cys 
                405                 410                 415     


Ile Pro Asn Thr Val Trp Thr Ile Gly Tyr Trp Leu Cys Tyr Ile Asn 
            420                 425                 430         


Ser Thr Ile Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys 
        435                 440                 445             


Lys Thr Phe Lys His Leu Leu Met Cys His Tyr Lys Asn Ile Gly Ala 
    450                 455                 460                 


Thr Arg 
465     


<210>  487
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  487

Met Asn Asn Ser Thr Asn Ser Ser Asn Asn Ser Leu Ala Leu Thr Ser 
1               5                   10                  15      


Pro Tyr Lys Thr Phe Glu Val Val Phe Ile Val Leu Val Ala Gly Ser 
            20                  25                  30          


Leu Ser Leu Val Thr Ile Ile Gly Asn Ile Leu Val Met Val Ser Ile 
        35                  40                  45              


Lys Val Asn Arg His Leu Gln Thr Val Asn Asn Tyr Phe Leu Phe Ser 
    50                  55                  60                  


Leu Ala Cys Ala Asp Leu Ile Ile Gly Val Phe Ser Met Asn Leu Tyr 
65                  70                  75                  80  


Thr Leu Tyr Thr Val Ile Gly Tyr Trp Pro Leu Gly Pro Val Val Cys 
                85                  90                  95      


Asp Leu Trp Leu Ala Leu Asp Tyr Val Val Ser Asn Ala Ser Val Met 
            100                 105                 110         


Asn Leu Leu Ile Ile Ser Phe Asp Arg Tyr Phe Cys Val Thr Lys Pro 
        115                 120                 125             


Leu Thr Tyr Pro Val Lys Arg Thr Thr Lys Met Ala Gly Met Met Ile 
    130                 135                 140                 


Ala Ala Ala Trp Val Leu Ser Phe Ile Leu Trp Ala Pro Ala Ile Leu 
145                 150                 155                 160 


Phe Trp Gln Phe Ile Val Gly Val Arg Thr Val Glu Asp Gly Glu Cys 
                165                 170                 175     


Tyr Ile Gln Phe Phe Ser Asn Ala Ala Val Thr Phe Gly Thr Ala Ile 
            180                 185                 190         


Ala Ala Phe Tyr Leu Pro Val Ile Ile Met Thr Val Leu Tyr Trp His 
        195                 200                 205             


Ile Ser Arg Ala Ser Lys Ser Arg Ile Lys Lys Asp Lys Lys Glu Pro 
    210                 215                 220                 


Val Ala Asn Gln Asp Pro Val Ser Pro Ser Leu Val Gln Gly Arg Ile 
225                 230                 235                 240 


Val Lys Pro Asn Asn Asn Asn Met Pro Ser Ser Asp Asp Gly Leu Glu 
                245                 250                 255     


His Asn Lys Ile Gln Asn Gly Lys Ala Pro Arg Asp Pro Val Thr Glu 
            260                 265                 270         


Asn Cys Val Gln Gly Glu Glu Lys Glu Ser Ser Asn Asp Ser Thr Ser 
        275                 280                 285             


Val Ser Ala Val Ala Ser Asn Met Arg Asp Asp Glu Ile Thr Gln Asp 
    290                 295                 300                 


Glu Asn Thr Val Ser Thr Ser Leu Gly His Ser Lys Asp Glu Asn Ser 
305                 310                 315                 320 


Lys Gln Thr Cys Ile Arg Ile Gly Thr Lys Thr Pro Lys Ser Asp Ser 
                325                 330                 335     


Cys Thr Pro Thr Asn Thr Thr Val Glu Val Val Gly Ser Ser Gly Gln 
            340                 345                 350         


Asn Gly Asp Glu Lys Gln Asn Ile Val Ala Arg Lys Ile Val Lys Met 
        355                 360                 365             


Thr Lys Gln Pro Ala Lys Lys Lys Pro Pro Pro Ser Arg Glu Lys Lys 
    370                 375                 380                 


Val Thr Arg Thr Ile Leu Ala Ile Leu Leu Ala Phe Ile Ile Thr Trp 
385                 390                 395                 400 


Ala Pro Tyr Asn Val Met Val Leu Ile Asn Thr Phe Cys Ala Pro Cys 
                405                 410                 415     


Ile Pro Asn Thr Val Trp Thr Ile Gly Tyr Trp Leu Cys Tyr Ile Asn 
            420                 425                 430         


Ser Thr Ile Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys 
        435                 440                 445             


Lys Thr Phe Lys His Leu Leu Met Cys His Tyr Lys Asn Ile Gly Ala 
    450                 455                 460                 


Thr Arg 
465     


<210>  488
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  488

Met Asn Asn Ser Thr Asn Ser Ser Asn Asn Ser Leu Ala Leu Thr Ser 
1               5                   10                  15      


Pro Tyr Lys Thr Phe Glu Val Val Phe Ile Val Leu Val Ala Gly Ser 
            20                  25                  30          


Leu Ser Leu Val Thr Ile Ile Gly Asn Ile Leu Val Met Val Ser Ile 
        35                  40                  45              


Lys Val Asn Arg His Leu Gln Thr Val Asn Asn Tyr Phe Leu Phe Ser 
    50                  55                  60                  


Leu Ala Cys Ala Asp Leu Ile Ile Gly Val Phe Ser Met Asn Leu Tyr 
65                  70                  75                  80  


Thr Leu Tyr Thr Val Ile Gly Tyr Trp Pro Leu Gly Pro Val Val Cys 
                85                  90                  95      


Asp Leu Trp Leu Ala Leu Asp Tyr Val Val Ser Asn Ala Ser Val Met 
            100                 105                 110         


Asn Leu Leu Ile Ile Ser Phe Asp Arg Tyr Phe Cys Val Thr Lys Pro 
        115                 120                 125             


Leu Thr Tyr Pro Val Lys Arg Thr Thr Lys Met Ala Gly Met Met Ile 
    130                 135                 140                 


Ala Ala Ala Trp Val Leu Ser Phe Ile Leu Trp Ala Pro Ala Ile Leu 
145                 150                 155                 160 


Phe Trp Gln Phe Ile Val Gly Val Arg Thr Val Glu Asp Gly Glu Cys 
                165                 170                 175     


Tyr Ile Gln Phe Phe Ser Asn Ala Ala Val Thr Phe Gly Thr Ala Ile 
            180                 185                 190         


Ala Ala Phe Tyr Leu Pro Val Ile Ile Met Thr Val Leu Tyr Trp His 
        195                 200                 205             


Ile Ser Arg Ala Ser Lys Ser Arg Ile Lys Lys Asp Lys Lys Glu Pro 
    210                 215                 220                 


Val Ala Asn Gln Asp Pro Val Ser Pro Ser Leu Val Gln Gly Arg Ile 
225                 230                 235                 240 


Val Lys Pro Asn Asn Asn Asn Met Pro Ser Ser Asp Asp Gly Leu Glu 
                245                 250                 255     


His Asn Lys Ile Gln Asn Gly Lys Ala Pro Arg Asp Pro Val Thr Glu 
            260                 265                 270         


Asn Cys Val Gln Gly Glu Glu Lys Glu Ser Ser Asn Asp Ser Thr Ser 
        275                 280                 285             


Val Ser Ala Val Ala Ser Asn Met Arg Asp Asp Glu Ile Thr Gln Asp 
    290                 295                 300                 


Glu Asn Thr Val Ser Thr Ser Leu Gly His Ser Lys Asp Glu Asn Ser 
305                 310                 315                 320 


Lys Gln Thr Cys Ile Arg Ile Gly Thr Lys Thr Pro Lys Ser Asp Ser 
                325                 330                 335     


Cys Thr Pro Thr Asn Thr Thr Val Glu Val Val Gly Ser Ser Gly Gln 
            340                 345                 350         


Asn Gly Asp Glu Lys Gln Asn Ile Val Ala Arg Lys Ile Val Lys Met 
        355                 360                 365             


Thr Lys Gln Pro Ala Lys Lys Lys Pro Pro Pro Ser Arg Glu Lys Lys 
    370                 375                 380                 


Val Thr Arg Thr Ile Leu Ala Ile Leu Leu Ala Phe Ile Ile Thr Trp 
385                 390                 395                 400 


Ala Pro Tyr Asn Val Met Val Leu Ile Asn Thr Phe Cys Ala Pro Cys 
                405                 410                 415     


Ile Pro Asn Thr Val Trp Thr Ile Gly Tyr Trp Leu Cys Tyr Ile Asn 
            420                 425                 430         


Ser Thr Ile Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys 
        435                 440                 445             


Lys Thr Phe Lys His Leu Leu Met Cys His Tyr Lys Asn Ile Gly Ala 
    450                 455                 460                 


Thr Arg 
465     


<210>  489
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  489

Met Asn Asn Ser Thr Asn Ser Ser Asn Asn Ser Leu Ala Leu Thr Ser 
1               5                   10                  15      


Pro Tyr Lys Thr Phe Glu Val Val Phe Ile Val Leu Val Ala Gly Ser 
            20                  25                  30          


Leu Ser Leu Val Thr Ile Ile Gly Asn Ile Leu Val Met Val Ser Ile 
        35                  40                  45              


Lys Val Asn Arg His Leu Gln Thr Val Asn Asn Tyr Phe Leu Phe Ser 
    50                  55                  60                  


Leu Ala Cys Ala Asp Leu Ile Ile Gly Val Phe Ser Met Asn Leu Tyr 
65                  70                  75                  80  


Thr Leu Tyr Thr Val Ile Gly Tyr Trp Pro Leu Gly Pro Val Val Cys 
                85                  90                  95      


Asp Leu Trp Leu Ala Leu Asp Tyr Val Val Ser Asn Ala Ser Val Met 
            100                 105                 110         


Asn Leu Leu Ile Ile Ser Phe Asp Arg Tyr Phe Cys Val Thr Lys Pro 
        115                 120                 125             


Leu Thr Tyr Pro Val Lys Arg Thr Thr Lys Met Ala Gly Met Met Ile 
    130                 135                 140                 


Ala Ala Ala Trp Val Leu Ser Phe Ile Leu Trp Ala Pro Ala Ile Leu 
145                 150                 155                 160 


Phe Trp Gln Phe Ile Val Gly Val Arg Thr Val Glu Asp Gly Glu Cys 
                165                 170                 175     


Tyr Ile Gln Phe Phe Ser Asn Ala Ala Val Thr Phe Gly Thr Ala Ile 
            180                 185                 190         


Ala Ala Phe Tyr Leu Pro Val Ile Ile Met Thr Val Leu Tyr Trp His 
        195                 200                 205             


Ile Ser Arg Ala Ser Lys Ser Arg Ile Lys Lys Asp Lys Lys Glu Pro 
    210                 215                 220                 


Val Ala Asn Gln Asp Pro Val Ser Pro Ser Leu Val Gln Gly Arg Ile 
225                 230                 235                 240 


Val Lys Pro Asn Asn Asn Asn Met Pro Ser Ser Asp Asp Gly Leu Glu 
                245                 250                 255     


His Asn Lys Ile Gln Asn Gly Lys Ala Pro Arg Asp Pro Val Thr Glu 
            260                 265                 270         


Asn Cys Val Gln Gly Glu Glu Lys Glu Ser Ser Asn Asp Ser Thr Ser 
        275                 280                 285             


Val Ser Ala Val Ala Ser Asn Met Arg Asp Asp Glu Ile Thr Gln Asp 
    290                 295                 300                 


Glu Asn Thr Val Ser Thr Ser Leu Gly His Ser Lys Asp Glu Asn Ser 
305                 310                 315                 320 


Lys Gln Thr Cys Ile Arg Ile Gly Thr Lys Thr Pro Lys Ser Asp Ser 
                325                 330                 335     


Cys Thr Pro Thr Asn Thr Thr Val Glu Val Val Gly Ser Ser Gly Gln 
            340                 345                 350         


Asn Gly Asp Glu Lys Gln Asn Ile Val Ala Arg Lys Ile Val Lys Met 
        355                 360                 365             


Thr Lys Gln Pro Ala Lys Lys Lys Pro Pro Pro Ser Arg Glu Lys Lys 
    370                 375                 380                 


Val Thr Arg Thr Ile Leu Ala Ile Leu Leu Ala Phe Ile Ile Thr Trp 
385                 390                 395                 400 


Ala Pro Tyr Asn Val Met Val Leu Ile Asn Thr Phe Cys Ala Pro Cys 
                405                 410                 415     


Ile Pro Asn Thr Val Trp Thr Ile Gly Tyr Trp Leu Cys Tyr Ile Asn 
            420                 425                 430         


Ser Thr Ile Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys 
        435                 440                 445             


Lys Thr Phe Lys His Leu Leu Met Cys His Tyr Lys Asn Ile Gly Ala 
    450                 455                 460                 


Thr Arg 
465     


<210>  490
<211>  503
<212>  PRT
<213>  Homo sapiens

<400>  490

Met Val Ser Ser Val Leu Cys Arg Cys Val Ala Ser Pro Pro Pro Asp 
1               5                   10                  15      


Ala Ala Ala Thr Ala Ala Ser Ser Ser Ala Ser Ser Pro Ala Ser Val 
            20                  25                  30          


Gly Asp Pro Cys Gly Gly Ala Ile Cys Gly Gly Pro Asp His Arg Leu 
        35                  40                  45              


Arg Leu Trp Arg Leu Phe Gln Thr Leu Asp Val Asn Arg Asp Gly Gly 
    50                  55                  60                  


Leu Cys Val Asn Asp Leu Ala Val Gly Leu Arg Arg Leu Gly Leu His 
65                  70                  75                  80  


Arg Thr Glu Gly Glu Leu Gln Lys Ile Val Gln Ala Gly Asp Lys Asp 
                85                  90                  95      


Leu Asp Gly Gln Leu Asp Phe Glu Glu Phe Val His Tyr Leu Gln Asp 
            100                 105                 110         


His Glu Lys Lys Leu Arg Leu Val Phe Lys Ser Leu Asp Lys Lys Asn 
        115                 120                 125             


Asp Gly Arg Ile Asp Ala Gln Glu Ile Met Gln Ser Leu Arg Asp Leu 
    130                 135                 140                 


Gly Val Lys Ile Ser Glu Gln Gln Ala Glu Lys Ile Leu Lys Ser Met 
145                 150                 155                 160 


Asp Lys Asn Gly Thr Met Thr Ile Asp Trp Asn Glu Trp Arg Asp Tyr 
                165                 170                 175     


His Leu Leu His Pro Val Glu Asn Ile Pro Glu Ile Ile Leu Tyr Trp 
            180                 185                 190         


Lys His Ser Thr Ile Phe Asp Val Gly Glu Asn Leu Thr Val Pro Asp 
        195                 200                 205             


Glu Phe Thr Val Glu Glu Arg Gln Thr Gly Met Trp Trp Arg His Leu 
    210                 215                 220                 


Val Ala Gly Gly Gly Ala Gly Ala Val Ser Arg Thr Cys Thr Ala Pro 
225                 230                 235                 240 


Leu Asp Arg Leu Lys Val Leu Met Gln Val His Ala Ser Arg Ser Asn 
                245                 250                 255     


Asn Met Gly Ile Val Gly Gly Phe Thr Gln Met Ile Arg Glu Gly Gly 
            260                 265                 270         


Ala Arg Ser Leu Trp Arg Gly Asn Gly Ile Asn Val Leu Lys Ile Ala 
        275                 280                 285             


Pro Glu Ser Ala Ile Lys Phe Met Ala Tyr Glu Gln Ile Lys Arg Leu 
    290                 295                 300                 


Val Gly Ser Asp Gln Glu Thr Leu Arg Ile His Glu Arg Leu Val Ala 
305                 310                 315                 320 


Gly Ser Leu Ala Gly Ala Ile Ala Gln Ser Ser Ile Tyr Pro Met Glu 
                325                 330                 335     


Val Leu Lys Thr Arg Met Ala Leu Arg Lys Thr Gly Gln Tyr Ser Gly 
            340                 345                 350         


Met Leu Asp Cys Ala Arg Arg Ile Leu Ala Arg Glu Gly Val Ala Ala 
        355                 360                 365             


Phe Tyr Lys Gly Tyr Val Pro Asn Met Leu Gly Ile Ile Pro Tyr Ala 
    370                 375                 380                 


Gly Ile Asp Leu Ala Val Tyr Glu Thr Leu Lys Asn Ala Trp Leu Gln 
385                 390                 395                 400 


His Tyr Ala Val Asn Ser Ala Asp Pro Gly Val Phe Val Leu Leu Ala 
                405                 410                 415     


Cys Gly Thr Met Ser Ser Thr Cys Gly Gln Leu Ala Ser Tyr Pro Leu 
            420                 425                 430         


Ala Leu Val Arg Thr Arg Met Gln Ala Gln Ala Ser Ile Glu Gly Ala 
        435                 440                 445             


Pro Glu Val Thr Met Ser Ser Leu Phe Lys His Ile Leu Arg Thr Glu 
    450                 455                 460                 


Gly Ala Phe Gly Leu Tyr Arg Gly Leu Ala Pro Asn Phe Met Lys Val 
465                 470                 475                 480 


Ile Pro Ala Val Ser Ile Ser Tyr Val Val Tyr Glu Asn Leu Lys Ile 
                485                 490                 495     


Thr Leu Gly Val Gln Ser Arg 
            500             


<210>  491
<211>  489
<212>  PRT
<213>  Homo sapiens

<400>  491

Met Leu Gln Met Leu Trp His Phe Leu Ala Ser Phe Phe Pro Arg Ala 
1               5                   10                  15      


Gly Cys His Gly Ser Arg Glu Gly Asp Asp Arg Glu Val Arg Gly Thr 
            20                  25                  30          


Pro Ala Pro Ala Trp Arg Asp Gln Met Ala Ser Phe Leu Gly Lys Gln 
        35                  40                  45              


Asp Gly Arg Ala Glu Ala Thr Glu Lys Arg Pro Thr Ile Leu Leu Val 
    50                  55                  60                  


Val Gly Pro Ala Glu Gln Phe Pro Lys Lys Ile Val Gln Ala Gly Asp 
65                  70                  75                  80  


Lys Asp Leu Asp Gly Gln Leu Asp Phe Glu Glu Phe Val His Tyr Leu 
                85                  90                  95      


Gln Asp His Glu Lys Lys Leu Arg Leu Val Phe Lys Ser Leu Asp Lys 
            100                 105                 110         


Lys Asn Asp Gly Arg Ile Asp Ala Gln Glu Ile Met Gln Ser Leu Arg 
        115                 120                 125             


Asp Leu Gly Val Lys Ile Ser Glu Gln Gln Ala Glu Lys Ile Leu Lys 
    130                 135                 140                 


Ser Met Asp Lys Asn Gly Thr Met Thr Ile Asp Trp Asn Glu Trp Arg 
145                 150                 155                 160 


Asp Tyr His Leu Leu His Pro Val Glu Asn Ile Pro Glu Ile Ile Leu 
                165                 170                 175     


Tyr Trp Lys His Ser Thr Ile Phe Asp Val Gly Glu Asn Leu Thr Val 
            180                 185                 190         


Pro Asp Glu Phe Thr Val Glu Glu Arg Gln Thr Gly Met Trp Trp Arg 
        195                 200                 205             


His Leu Val Ala Gly Gly Gly Ala Gly Ala Val Ser Arg Thr Cys Thr 
    210                 215                 220                 


Ala Pro Leu Asp Arg Leu Lys Val Leu Met Gln Val His Ala Ser Arg 
225                 230                 235                 240 


Ser Asn Asn Met Gly Ile Val Gly Gly Phe Thr Gln Met Ile Arg Glu 
                245                 250                 255     


Gly Gly Ala Arg Ser Leu Trp Arg Gly Asn Gly Ile Asn Val Leu Lys 
            260                 265                 270         


Ile Ala Pro Glu Ser Ala Ile Lys Phe Met Ala Tyr Glu Gln Ile Lys 
        275                 280                 285             


Arg Leu Val Gly Ser Asp Gln Glu Thr Leu Arg Ile His Glu Arg Leu 
    290                 295                 300                 


Val Ala Gly Ser Leu Ala Gly Ala Ile Ala Gln Ser Ser Ile Tyr Pro 
305                 310                 315                 320 


Met Glu Val Leu Lys Thr Arg Met Ala Leu Arg Lys Thr Gly Gln Tyr 
                325                 330                 335     


Ser Gly Met Leu Asp Cys Ala Arg Arg Ile Leu Ala Arg Glu Gly Val 
            340                 345                 350         


Ala Ala Phe Tyr Lys Gly Tyr Val Pro Asn Met Leu Gly Ile Ile Pro 
        355                 360                 365             


Tyr Ala Gly Ile Asp Leu Ala Val Tyr Glu Thr Leu Lys Asn Ala Trp 
    370                 375                 380                 


Leu Gln His Tyr Ala Val Asn Ser Ala Asp Pro Gly Val Phe Val Leu 
385                 390                 395                 400 


Leu Ala Cys Gly Thr Met Ser Ser Thr Cys Gly Gln Leu Ala Ser Tyr 
                405                 410                 415     


Pro Leu Ala Leu Val Arg Thr Arg Met Gln Ala Gln Ala Ser Ile Glu 
            420                 425                 430         


Gly Ala Pro Glu Val Thr Met Ser Ser Leu Phe Lys His Ile Leu Arg 
        435                 440                 445             


Thr Glu Gly Ala Phe Gly Leu Tyr Arg Gly Leu Ala Pro Asn Phe Met 
    450                 455                 460                 


Lys Val Ile Pro Ala Val Ser Ile Ser Tyr Val Val Tyr Glu Asn Leu 
465                 470                 475                 480 


Lys Ile Thr Leu Gly Val Gln Ser Arg 
                485                 


<210>  492
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  492

Met Gln Ser Leu Arg Asp Leu Gly Val Lys Ile Ser Glu Gln Gln Ala 
1               5                   10                  15      


Glu Lys Ile Leu Lys Ser Met Asp Lys Asn Gly Thr Met Thr Ile Asp 
            20                  25                  30          


Trp Asn Glu Trp Arg Asp Tyr His Leu Leu His Pro Val Glu Asn Ile 
        35                  40                  45              


Pro Glu Ile Ile Leu Tyr Trp Lys His Ser Thr Ile Phe Asp Val Gly 
    50                  55                  60                  


Glu Asn Leu Thr Val Pro Asp Glu Phe Thr Val Glu Glu Arg Gln Thr 
65                  70                  75                  80  


Gly Met Trp Trp Arg His Leu Val Ala Gly Gly Gly Ala Gly Ala Val 
                85                  90                  95      


Ser Arg Thr Cys Thr Ala Pro Leu Asp Arg Leu Lys Val Leu Met Gln 
            100                 105                 110         


Val His Ala Ser Arg Ser Asn Asn Met Gly Ile Val Gly Gly Phe Thr 
        115                 120                 125             


Gln Met Ile Arg Glu Gly Gly Ala Arg Ser Leu Trp Arg Gly Asn Gly 
    130                 135                 140                 


Ile Asn Val Leu Lys Ile Ala Pro Glu Ser Ala Ile Lys Phe Met Ala 
145                 150                 155                 160 


Tyr Glu Gln Ile Lys Arg Leu Val Gly Ser Asp Gln Glu Thr Leu Arg 
                165                 170                 175     


Ile His Glu Arg Leu Val Ala Gly Ser Leu Ala Gly Ala Ile Ala Gln 
            180                 185                 190         


Ser Ser Ile Tyr Pro Met Glu Val Leu Lys Thr Arg Met Ala Leu Arg 
        195                 200                 205             


Lys Thr Gly Gln Tyr Ser Gly Met Leu Asp Cys Ala Arg Arg Ile Leu 
    210                 215                 220                 


Ala Arg Glu Gly Val Ala Ala Phe Tyr Lys Gly Tyr Val Pro Asn Met 
225                 230                 235                 240 


Leu Gly Ile Ile Pro Tyr Ala Gly Ile Asp Leu Ala Val Tyr Glu Thr 
                245                 250                 255     


Leu Lys Asn Ala Trp Leu Gln His Tyr Ala Val Asn Ser Ala Asp Pro 
            260                 265                 270         


Gly Val Phe Val Leu Leu Ala Cys Gly Thr Met Ser Ser Thr Cys Gly 
        275                 280                 285             


Gln Leu Ala Ser Tyr Pro Leu Ala Leu Val Arg Thr Arg Met Gln Ala 
    290                 295                 300                 


Gln Ala Ser Ile Glu Gly Ala Pro Glu Val Thr Met Ser Ser Leu Phe 
305                 310                 315                 320 


Lys His Ile Leu Arg Thr Glu Gly Ala Phe Gly Leu Tyr Arg Gly Leu 
                325                 330                 335     


Ala Pro Asn Phe Met Lys Val Ile Pro Ala Val Ser Ile Ser Tyr Val 
            340                 345                 350         


Val Tyr Glu Asn Leu Lys Ile Thr Leu Gly Val Gln Ser Arg 
        355                 360                 365     


<210>  493
<211>  1092
<212>  PRT
<213>  Homo sapiens

<400>  493

Met Gly Ala Ala Gly Leu Leu Gly Val Phe Leu Ala Leu Val Ala Pro 
1               5                   10                  15      


Gly Val Leu Gly Ile Ser Cys Gly Ser Pro Pro Pro Ile Leu Asn Gly 
            20                  25                  30          


Arg Ile Ser Tyr Tyr Ser Thr Pro Ile Ala Val Gly Thr Val Ile Arg 
        35                  40                  45              


Tyr Ser Cys Ser Gly Thr Phe Arg Leu Ile Gly Glu Lys Ser Leu Leu 
    50                  55                  60                  


Cys Ile Thr Lys Asp Lys Val Asp Gly Thr Trp Asp Lys Pro Ala Pro 
65                  70                  75                  80  


Lys Cys Glu Tyr Phe Asn Lys Tyr Ser Ser Cys Pro Glu Pro Ile Val 
                85                  90                  95      


Pro Gly Gly Tyr Lys Ile Arg Gly Ser Thr Pro Tyr Arg His Gly Asp 
            100                 105                 110         


Ser Val Thr Phe Ala Cys Lys Thr Asn Phe Ser Met Asn Gly Asn Lys 
        115                 120                 125             


Ser Val Trp Cys Gln Ala Asn Asn Met Trp Gly Pro Thr Arg Leu Pro 
    130                 135                 140                 


Thr Cys Val Ser Val Phe Pro Leu Glu Cys Pro Ala Leu Pro Met Ile 
145                 150                 155                 160 


His Asn Gly His His Thr Ser Glu Asn Val Gly Ser Ile Ala Pro Gly 
                165                 170                 175     


Leu Ser Val Thr Tyr Ser Cys Glu Ser Gly Tyr Leu Leu Val Gly Glu 
            180                 185                 190         


Lys Ile Ile Asn Cys Leu Ser Ser Gly Lys Trp Ser Ala Val Pro Pro 
        195                 200                 205             


Thr Cys Glu Glu Ala Arg Cys Lys Ser Leu Gly Arg Phe Pro Asn Gly 
    210                 215                 220                 


Lys Val Lys Glu Pro Pro Ile Leu Arg Val Gly Val Thr Ala Asn Phe 
225                 230                 235                 240 


Phe Cys Asp Glu Gly Tyr Arg Leu Gln Gly Pro Pro Ser Ser Arg Cys 
                245                 250                 255     


Val Ile Ala Gly Gln Gly Val Ala Trp Thr Lys Met Pro Val Cys Glu 
            260                 265                 270         


Glu Ile Phe Cys Pro Ser Pro Pro Pro Ile Leu Asn Gly Arg His Ile 
        275                 280                 285             


Gly Asn Ser Leu Ala Asn Val Ser Tyr Gly Ser Ile Val Thr Tyr Thr 
    290                 295                 300                 


Cys Asp Pro Asp Pro Glu Glu Gly Val Asn Phe Ile Leu Ile Gly Glu 
305                 310                 315                 320 


Ser Thr Leu Arg Cys Thr Val Asp Ser Gln Lys Thr Gly Thr Trp Ser 
                325                 330                 335     


Gly Pro Ala Pro Arg Cys Glu Leu Ser Thr Ser Ala Val Gln Cys Pro 
            340                 345                 350         


His Pro Gln Ile Leu Arg Gly Arg Met Val Ser Gly Gln Lys Asp Arg 
        355                 360                 365             


Tyr Thr Tyr Asn Asp Thr Val Ile Phe Ala Cys Met Phe Gly Phe Thr 
    370                 375                 380                 


Leu Lys Gly Ser Lys Gln Ile Arg Cys Asn Ala Gln Gly Thr Trp Glu 
385                 390                 395                 400 


Pro Ser Ala Pro Val Cys Glu Lys Glu Cys Gln Ala Pro Pro Asn Ile 
                405                 410                 415     


Leu Asn Gly Gln Lys Glu Asp Arg His Met Val Arg Phe Asp Pro Gly 
            420                 425                 430         


Thr Ser Ile Lys Tyr Ser Cys Asn Pro Gly Tyr Val Leu Val Gly Glu 
        435                 440                 445             


Glu Ser Ile Gln Cys Thr Ser Glu Gly Val Trp Thr Pro Pro Val Pro 
    450                 455                 460                 


Gln Cys Lys Val Ala Ala Cys Glu Ala Thr Gly Arg Gln Leu Leu Thr 
465                 470                 475                 480 


Lys Pro Gln His Gln Phe Val Arg Pro Asp Val Asn Ser Ser Cys Gly 
                485                 490                 495     


Glu Gly Tyr Lys Leu Ser Gly Ser Val Tyr Gln Glu Cys Gln Gly Thr 
            500                 505                 510         


Ile Pro Trp Phe Met Glu Ile Arg Leu Cys Lys Glu Ile Thr Cys Pro 
        515                 520                 525             


Pro Pro Pro Val Ile Tyr Asn Gly Ala His Thr Gly Ser Ser Leu Glu 
    530                 535                 540                 


Asp Phe Pro Tyr Gly Thr Thr Val Thr Tyr Thr Cys Asn Pro Gly Pro 
545                 550                 555                 560 


Glu Arg Gly Val Glu Phe Ser Leu Ile Gly Glu Ser Thr Ile Arg Cys 
                565                 570                 575     


Thr Ser Asn Asp Gln Glu Arg Gly Thr Trp Ser Gly Pro Ala Pro Leu 
            580                 585                 590         


Cys Lys Leu Ser Leu Leu Ala Val Gln Cys Ser His Val His Ile Ala 
        595                 600                 605             


Asn Gly Tyr Lys Ile Ser Gly Lys Glu Ala Pro Tyr Phe Tyr Asn Asp 
    610                 615                 620                 


Thr Val Thr Phe Lys Cys Tyr Ser Gly Phe Thr Leu Lys Gly Ser Ser 
625                 630                 635                 640 


Gln Ile Arg Cys Lys Ala Asp Asn Thr Trp Asp Pro Glu Ile Pro Val 
                645                 650                 655     


Cys Glu Lys Gly Cys Gln Ser Pro Pro Gly Leu His His Gly Arg His 
            660                 665                 670         


Thr Gly Gly Asn Thr Val Phe Phe Val Ser Gly Met Thr Val Asp Tyr 
        675                 680                 685             


Thr Cys Asp Pro Gly Tyr Leu Leu Val Gly Asn Lys Ser Ile His Cys 
    690                 695                 700                 


Met Pro Ser Gly Asn Trp Ser Pro Ser Ala Pro Arg Cys Glu Glu Thr 
705                 710                 715                 720 


Cys Gln His Val Arg Gln Ser Leu Gln Glu Leu Pro Ala Gly Ser Arg 
                725                 730                 735     


Val Glu Leu Val Asn Thr Ser Cys Gln Asp Gly Tyr Gln Leu Thr Gly 
            740                 745                 750         


His Ala Tyr Gln Met Cys Gln Asp Ala Glu Asn Gly Ile Trp Phe Lys 
        755                 760                 765             


Lys Ile Pro Leu Cys Lys Val Ile His Cys His Pro Pro Pro Val Ile 
    770                 775                 780                 


Val Asn Gly Lys His Thr Gly Met Met Ala Glu Asn Phe Leu Tyr Gly 
785                 790                 795                 800 


Asn Glu Val Ser Tyr Glu Cys Asp Gln Gly Phe Tyr Leu Leu Gly Glu 
                805                 810                 815     


Lys Lys Leu Gln Cys Arg Ser Asp Ser Lys Gly His Gly Ser Trp Ser 
            820                 825                 830         


Gly Pro Ser Pro Gln Cys Leu Arg Ser Pro Pro Val Thr Arg Cys Pro 
        835                 840                 845             


Asn Pro Glu Val Lys His Gly Tyr Lys Leu Asn Lys Thr His Ser Ala 
    850                 855                 860                 


Tyr Ser His Asn Asp Ile Val Tyr Val Asp Cys Asn Pro Gly Phe Ile 
865                 870                 875                 880 


Met Asn Gly Ser Arg Val Ile Arg Cys His Thr Asp Asn Thr Trp Val 
                885                 890                 895     


Pro Gly Val Pro Thr Cys Ile Lys Lys Ala Phe Ile Gly Cys Pro Pro 
            900                 905                 910         


Pro Pro Lys Thr Pro Asn Gly Asn His Thr Gly Gly Asn Ile Ala Arg 
        915                 920                 925             


Phe Ser Pro Gly Met Ser Ile Leu Tyr Ser Cys Asp Gln Gly Tyr Leu 
    930                 935                 940                 


Leu Val Gly Glu Ala Leu Leu Leu Cys Thr His Glu Gly Thr Trp Ser 
945                 950                 955                 960 


Gln Pro Ala Pro His Cys Lys Glu Val Asn Cys Ser Ser Pro Ala Asp 
                965                 970                 975     


Met Asp Gly Ile Gln Lys Gly Leu Glu Pro Arg Lys Met Tyr Gln Tyr 
            980                 985                 990         


Gly Ala Val Val Thr Leu Glu Cys  Glu Asp Gly Tyr Met  Leu Glu Gly 
        995                 1000                 1005             


Ser Pro  Gln Ser Gln Cys Gln  Ser Asp His Gln Trp  Asn Pro Pro 
    1010                 1015                 1020             


Leu Ala  Val Cys Arg Ser Arg  Ser Leu Ala Pro Val  Leu Cys Gly 
    1025                 1030                 1035             


Ile Ala  Ala Gly Leu Ile Leu  Leu Thr Phe Leu Ile  Val Ile Thr 
    1040                 1045                 1050             


Leu Tyr  Val Ile Ser Lys His  Arg Ala Arg Asn Tyr  Tyr Thr Asp 
    1055                 1060                 1065             


Thr Ser  Gln Lys Glu Ala Phe  His Leu Glu Ala Arg  Glu Val Tyr 
    1070                 1075                 1080             


Ser Val  Asp Pro Tyr Asn Pro  Ala Ser 
    1085                 1090         


<210>  494
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  494

Met Phe Pro Ala Gln Ala Lys Glu Asn Ala Gly Phe Ser Gly Cys Gly 
1               5                   10                  15      


Gly Asp Thr Glu Ile Asp Trp Lys Ala Tyr Met Ala Glu Val Glu Gly 
            20                  25                  30          


Val Ile Asn Gly Thr Tyr Asp Tyr Thr Gln Leu Gln Gly Asp Thr Gly 
        35                  40                  45              


Pro Leu Val Tyr Pro Ala Gly Phe Val Tyr Ile Phe Met Gly Leu Tyr 
    50                  55                  60                  


Tyr Ala Thr Ser Arg Gly Thr Asp Ile Arg Met Ala Gln Asn Ile Phe 
65                  70                  75                  80  


Ala Val Leu Tyr Leu Ala Thr Leu Leu Leu Val Phe Leu Ile Tyr His 
                85                  90                  95      


Gln Thr Cys Lys Val Pro Pro Phe Val Phe Phe Phe Met Cys Cys Ala 
            100                 105                 110         


Ser Tyr Arg Val His Ser Ile Phe Val Leu Arg Leu Phe Asn Asp Pro 
        115                 120                 125             


Val Ala Met Val Leu Leu Phe Leu Ser Ile Asn Leu Leu Leu Ala Gln 
    130                 135                 140                 


Arg Trp Gly Trp Gly Cys Cys Phe Phe Ser Leu Ala Val Ser Val Lys 
145                 150                 155                 160 


Met Asn Val Leu Leu Phe Ala Pro Gly Leu Leu Phe Leu Leu Leu Thr 
                165                 170                 175     


Gln Phe Gly Phe Arg Gly Ala Leu Pro Lys Leu Gly Ile Cys Ala Gly 
            180                 185                 190         


Leu Gln Val Val Leu Gly Leu Pro Phe Leu Leu Glu Asn Pro Ser Gly 
        195                 200                 205             


Tyr Leu Ser Arg Ser Phe Asp Leu Gly Arg Gln Phe Leu Phe His Trp 
    210                 215                 220                 


Thr Val Asn Trp Arg Phe Leu Pro Glu Ala Leu Phe Leu His Arg Ala 
225                 230                 235                 240 


Phe His Leu Ala Leu Leu Thr Ala His Leu Thr Leu Leu Leu Leu Phe 
                245                 250                 255     


Ala Leu Cys Arg Trp His Arg Thr Gly Glu Ser Ile Leu Ser Leu Leu 
            260                 265                 270         


Arg Asp Pro Ser Lys Arg Lys Val Pro Pro Gln Pro Leu Thr Pro Asn 
        275                 280                 285             


Gln Ile Val Ser Thr Leu Phe Thr Ser Asn Phe Ile Gly Ile Cys Phe 
    290                 295                 300                 


Ser Arg Ser Leu His Tyr Gln Phe Tyr Val Trp Tyr Phe His Thr Leu 
305                 310                 315                 320 


Pro Tyr Leu Leu Trp Ala Met Pro Ala Arg Trp Leu Thr His Leu Leu 
                325                 330                 335     


Arg Leu Leu Val Leu Gly Leu Ile Glu Leu Ser Trp Asn Thr Tyr Pro 
            340                 345                 350         


Ser Thr Ser Cys Ser Ser Ala Ala Leu His Ile Cys His Ala Val Ile 
        355                 360                 365             


Leu Leu Gln Leu Trp Leu Gly Pro Gln Pro Phe Pro Lys Ser Thr Gln 
    370                 375                 380                 


His Ser Lys Lys Ala His 
385                 390 


<210>  495
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  495

Met Ala Pro Ala Arg Gly Arg Leu Pro Pro Ala Leu Trp Val Val Thr 
1               5                   10                  15      


Ala Ala Ala Ala Ala Ala Thr Cys Val Ser Ala Ala Arg Gly Glu Val 
            20                  25                  30          


Asn Leu Leu Asp Thr Ser Thr Ile His Gly Asp Trp Gly Trp Leu Thr 
        35                  40                  45              


Tyr Pro Ala His Gly Trp Asp Ser Ile Asn Glu Val Asp Glu Ser Phe 
    50                  55                  60                  


Gln Pro Ile His Thr Tyr Gln Val Cys Asn Val Met Ser Pro Asn Gln 
65                  70                  75                  80  


Asn Asn Trp Leu Arg Thr Ser Trp Val Pro Arg Asp Gly Ala Arg Arg 
                85                  90                  95      


Val Tyr Ala Glu Ile Lys Phe Thr Leu Arg Asp Cys Asn Ser Met Pro 
            100                 105                 110         


Gly Val Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Leu Glu 
        115                 120                 125             


Ser Asp Arg Asp Leu Gly Ala Ser Thr Gln Glu Ser Gln Phe Leu Lys 
    130                 135                 140                 


Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gly Ala Asp Leu Gly 
145                 150                 155                 160 


Val Arg Arg Leu Lys Leu Asn Thr Glu Val Arg Ser Val Gly Pro Leu 
                165                 170                 175     


Ser Lys Arg Gly Phe Tyr Leu Ala Phe Gln Asp Ile Gly Ala Cys Leu 
            180                 185                 190         


Ala Ile Leu Ser Leu Arg Ile Tyr Tyr Lys Lys Cys Pro Ala Met Val 
        195                 200                 205             


Arg Asn Leu Ala Ala Phe Ser Glu Ala Val Thr Gly Ala Asp Ser Ser 
    210                 215                 220                 


Ser Leu Val Glu Val Arg Gly Gln Cys Val Arg His Ser Glu Glu Arg 
225                 230                 235                 240 


Asp Thr Pro Lys Met Tyr Cys Ser Ala Glu Gly Glu Trp Leu Val Pro 
                245                 250                 255     


Ile Gly Lys Cys Val Cys Ser Ala Gly Tyr Glu Glu Arg Arg Asp Ala 
            260                 265                 270         


Cys Val Ala Cys Glu Leu Gly Phe Tyr Lys Ser Ala Pro Gly Asp Gln 
        275                 280                 285             


Leu Cys Ala Arg Cys Pro Pro His Ser His Ser Ala Ala Pro Ala Ala 
    290                 295                 300                 


Gln Ala Cys His Cys Asp Leu Ser Tyr Tyr Arg Ala Ala Leu Asp Pro 
305                 310                 315                 320 


Pro Ser Ser Ala Cys Thr Arg Pro Pro Ser Ala Pro Val Asn Leu Ile 
                325                 330                 335     


Ser Ser Val Asn Gly Thr Ser Val Thr Leu Glu Trp Ala Pro Pro Leu 
            340                 345                 350         


Asp Pro Gly Gly Arg Ser Asp Ile Thr Tyr Asn Ala Val Cys Arg Arg 
        355                 360                 365             


Cys Pro Trp Ala Leu Ser Arg Cys Glu Ala Cys Gly Ser Gly Thr Arg 
    370                 375                 380                 


Phe Val Pro Gln Gln Thr Ser Leu Val Gln Ala Ser Leu Leu Val Ala 
385                 390                 395                 400 


Asn Leu Leu Ala His Met Asn Tyr Ser Phe Trp Ile Glu Ala Val Asn 
                405                 410                 415     


Gly Val Ser Asp Leu Ser Pro Glu Pro Arg Arg Ala Ala Val Val Asn 
            420                 425                 430         


Ile Thr Thr Asn Gln Ala Gly Arg Arg Arg Asn Ser Val Pro Gln Arg 
        435                 440                 445             


Pro Gly Pro Pro Ala Ser Pro Ala Ser Asp Pro Ser Arg Asp Gln Ser 
    450                 455                 460                 


Ser Ala Gly Asp Val Leu Trp Ala Phe Arg Gln Val Pro Leu Trp Pro 
465                 470                 475                 480 


Cys Ala Pro His Gln Asp Pro Glu Leu Glu Ala Leu His Cys Leu 
                485                 490                 495 


<210>  496
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  496

Met Arg Arg Ala Ala Leu Trp Leu Trp Leu Cys Ala Leu Ala Leu Ser 
1               5                   10                  15      


Leu Gln Pro Ala Leu Pro Gln Ile Val Ala Thr Asn Leu Pro Pro Glu 
            20                  25                  30          


Asp Gln Asp Gly Ser Gly Asp Asp Ser Asp Asn Phe Ser Gly Ser Gly 
        35                  40                  45              


Ala Gly Ala Leu Gln Asp Ile Thr Leu Ser Gln Gln Thr Pro Ser Thr 
    50                  55                  60                  


Trp Lys Asp Thr Gln Leu Leu Thr Ala Ile Pro Thr Ser Pro Glu Pro 
65                  70                  75                  80  


Thr Gly Leu Glu Ala Thr Ala Ala Ser Thr Ser Thr Leu Pro Ala Gly 
                85                  90                  95      


Glu Gly Pro Lys Glu Gly Glu Ala Val Val Leu Pro Glu Val Glu Pro 
            100                 105                 110         


Gly Leu Thr Ala Arg Glu Gln Glu Ala Thr Pro Arg Pro Arg Glu Thr 
        115                 120                 125             


Thr Gln Leu Pro Thr Thr His Gln Ala Ser Thr Thr Thr Ala Thr Thr 
    130                 135                 140                 


Ala Gln Glu Pro Ala Thr Ser His Pro His Arg Asp Met Gln Pro Gly 
145                 150                 155                 160 


His His Glu Thr Ser Thr Pro Ala Gly Pro Ser Gln Ala Asp Leu His 
                165                 170                 175     


Thr Pro His Thr Glu Asp Gly Gly Pro Ser Ala Thr Glu Arg Ala Ala 
            180                 185                 190         


Glu Asp Gly Ala Ser Ser Gln Leu Pro Ala Ala Glu Gly Ser Gly Glu 
        195                 200                 205             


Gln Asp Phe Thr Phe Glu Thr Ser Gly Glu Asn Thr Ala Val Val Ala 
    210                 215                 220                 


Val Glu Pro Asp Arg Arg Asn Gln Ser Pro Val Asp Gln Gly Ala Thr 
225                 230                 235                 240 


Gly Ala Ser Gln Gly Leu Leu Asp Arg Lys Glu Val Leu Gly Gly Val 
                245                 250                 255     


Ile Ala Gly Gly Leu Val Gly Leu Ile Phe Ala Val Cys Leu Val Gly 
            260                 265                 270         


Phe Met Leu Tyr Arg Met Lys Lys Lys Asp Glu Gly Ser Tyr Ser Leu 
        275                 280                 285             


Glu Glu Pro Lys Gln Ala Asn Gly Gly Ala Tyr Gln Lys Pro Thr Lys 
    290                 295                 300                 


Gln Glu Glu Phe Tyr Ala 
305                 310 


<210>  497
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  497

Met Gly Ile Leu Ser Val Asp Leu Leu Ile Thr Leu Gln Ile Leu Pro 
1               5                   10                  15      


Val Phe Phe Ser Asn Cys Leu Phe Leu Ala Leu Tyr Asp Ser Val Ile 
            20                  25                  30          


Leu Leu Lys His Val Val Leu Leu Leu Ser Arg Ser Lys Ser Thr Arg 
        35                  40                  45              


Gly Glu Trp Arg Arg Met Leu Thr Ser Glu Gly Leu Arg Cys Val Trp 
    50                  55                  60                  


Lys Ser Phe Leu Leu Asp Ala Tyr Lys Gln Leu Asn Cys Pro Pro Ser 
65                  70                  75                  80  


Gly Phe Ser Lys Asp Gly His Ile Leu Leu Val Tyr Glu Ala Tyr Lys 
                85                  90                  95      


Ser Arg Leu Leu Val Tyr Ser His Leu Asp Leu Trp Met Val Lys Leu 
            100                 105                 110         


Gly Glu Asp Ala Pro Asn Ser Ser Val Val His Val Ser Ser Thr Glu 
        115                 120                 125             


Gly Gly Asp Asn Ser Gly Asn Gly Thr Gln Glu Lys Ile Ala Glu Gly 
    130                 135                 140                 


Ala Thr Cys His Leu Leu Asp Phe Ala Ser Pro Glu Arg Pro Leu Val 
145                 150                 155                 160 


Val Asn Phe Gly Ser Ala Thr Pro Pro Phe Thr Ser Gln Leu Pro Ala 
                165                 170                 175     


Phe Arg Lys Leu Val Glu Glu Phe Ser Ser Val Ala Asp Phe Leu Leu 
            180                 185                 190         


Val Tyr Ile Asp Glu Ala His Pro Ser Asp Gly Trp Ala Ile Pro Gly 
        195                 200                 205             


Asp Ser Ser Leu Ser Phe Glu Val Lys Lys His Gln Asn Gln Glu Asp 
    210                 215                 220                 


Arg Cys Ala Ala Ala Gln Gln Leu Leu Glu Arg Phe Ser Leu Pro Pro 
225                 230                 235                 240 


Gln Cys Arg Val Val Ala Asp Arg Met Asp Asn Asn Ala Asn Ile Ala 
                245                 250                 255     


Tyr Gly Val Ala Phe Glu Arg Val Cys Ile Val Gln Arg Gln Lys Ile 
            260                 265                 270         


Ala Tyr Leu Gly Gly Lys Gly Pro Phe Ser Tyr Asn Leu Gln Glu Val 
        275                 280                 285             


Arg His Trp Leu Glu Lys Asn Phe Ser Lys Arg Lys Lys Thr Arg Leu 
    290                 295                 300                 


Ala Gly 
305     


<210>  498
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  498

Met Phe Glu Thr Met Ala Ile Glu Ile Glu Gln Leu Leu Ala Arg Leu 
1               5                   10                  15      


Thr Gly Val Asn Asp Lys Met Ala Glu Tyr Thr Asn Ser Ala Gly Val 
            20                  25                  30          


Pro Ser Leu Asn Ala Ala Leu Met His Thr Leu Gln Arg His Arg Asp 
        35                  40                  45              


Ile Leu Gln Asp Tyr Thr His Glu Phe His Lys Thr Lys Ala Asn Phe 
    50                  55                  60                  


Met Ala Ile Arg Glu Arg Glu Asn Leu Met Gly Ser Val Arg Lys Asp 
65                  70                  75                  80  


Ile Glu Ser Tyr Lys Ser Gly Ser Gly Val Asn Asn Arg Arg Thr Glu 
                85                  90                  95      


Leu Phe Leu Lys Glu His Asp His Leu Arg Asn Ser Asp Arg Leu Ile 
            100                 105                 110         


Glu Glu Thr Ile Ser Ile Ala Met Ala Thr Lys Glu Asn Met Thr Ser 
        115                 120                 125             


Gln Arg Gly Met Leu Lys Ser Ile His Ser Lys Met Asn Thr Leu Ala 
    130                 135                 140                 


Asn Arg Phe Pro Ala Val Asn Ser Leu Ile Gln Arg Ile Asn Leu Arg 
145                 150                 155                 160 


Lys Arg Arg Asp Ser Leu Ile Leu Gly Gly Val Ile Gly Ile Cys Thr 
                165                 170                 175     


Ile Leu Leu Leu Leu Tyr Ala Phe His 
            180                 185 


<210>  499
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  499

Met Ala Ala Gly Thr Ser Ser Tyr Trp Glu Asp Leu Arg Lys Gln Ala 
1               5                   10                  15      


Arg Gln Leu Glu Asn Glu Leu Asp Leu Lys Leu Val Ser Phe Ser Lys 
            20                  25                  30          


Leu Cys Thr Ser Tyr Ser His Ser Ser Thr Arg Asp Gly Arg Arg Asp 
        35                  40                  45              


Ser Ser Asp Thr Thr Pro Leu Leu Asn Gly Ser Ser Gln Asp Arg Met 
    50                  55                  60                  


Phe Glu Thr Met Ala Ile Glu Ile Glu Gln Leu Leu Ala Arg Leu Thr 
65                  70                  75                  80  


Gly Val Asn Asp Lys Met Ala Glu Tyr Thr Asn Ser Ala Gly Val Pro 
                85                  90                  95      


Ser Leu Asn Ala Ala Leu Met His Thr Leu Gln Arg His Arg Asp Ile 
            100                 105                 110         


Leu Gln Asp Tyr Thr His Glu Phe His Lys Thr Lys Ala Asn Phe Met 
        115                 120                 125             


Ala Ile Arg Glu Arg Glu Asn Leu Met Gly Ser Val Arg Lys Asp Ile 
    130                 135                 140                 


Glu Ser Tyr Lys Ser Gly Ser Gly Val Asn Asn Arg Arg Thr Glu Leu 
145                 150                 155                 160 


Phe Leu Lys Glu His Asp His Leu Arg Asn Ser Asp Arg Leu Ile Glu 
                165                 170                 175     


Glu Thr Ile Ser Ile Ala Met Ala Thr Lys Glu Asn Met Thr Ser Gln 
            180                 185                 190         


Arg Gly Met Leu Lys Ser Ile His Ser Lys Met Asn Thr Leu Ala Asn 
        195                 200                 205             


Arg Phe Pro Ala Val Asn Ser Leu Ile Gln Arg Ile Asn Leu Arg Lys 
    210                 215                 220                 


Arg Arg Asp Ser Leu Ile Leu Gly Gly Val Ile Gly Ile Cys Thr Ile 
225                 230                 235                 240 


Leu Leu Leu Leu Tyr Ala Phe His 
                245             


<210>  500
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  500

Met Ala Ala Leu Thr Ile Ala Thr Gly Thr Gly Asn Trp Phe Ser Ala 
1               5                   10                  15      


Leu Ala Leu Gly Val Thr Leu Leu Lys Cys Leu Leu Ile Pro Thr Tyr 
            20                  25                  30          


His Ser Thr Asp Phe Glu Val His Arg Asn Trp Leu Ala Ile Thr His 
        35                  40                  45              


Ser Leu Pro Ile Ser Gln Trp Tyr Tyr Glu Ala Thr Ser Glu Trp Thr 
    50                  55                  60                  


Leu Asp Tyr Pro Pro Phe Phe Ala Trp Phe Glu Tyr Ile Leu Ser His 
65                  70                  75                  80  


Val Ala Lys Tyr Phe Asp Gln Glu Met Leu Asn Val His Asn Leu Asn 
                85                  90                  95      


Tyr Ser Ser Ser Arg Thr Leu Leu Phe Gln Arg Phe Ser Val Ile Phe 
            100                 105                 110         


Met Asp Val Leu Phe Val Tyr Ala Val Arg Glu Cys Cys Lys Cys Ile 
        115                 120                 125             


Asp Gly Lys Lys Val Gly Lys Glu Leu Thr Glu Lys Pro Lys Phe Ile 
    130                 135                 140                 


Leu Ser Val Leu Leu Leu Trp Asn Phe Gly Leu Leu Ile Val Asp His 
145                 150                 155                 160 


Ile His Phe Gln Tyr Asn Gly Phe Leu Phe Gly Leu Met Leu Leu Ser 
                165                 170                 175     


Ile Ala Arg Leu Phe Gln Lys Arg His Met Glu Gly Ala Phe Leu Phe 
            180                 185                 190         


Ala Val Leu Leu His Phe Lys His Ile Tyr Leu Tyr Val Ala Pro Ala 
        195                 200                 205             


Tyr Gly Val Tyr Leu Leu Arg Ser Tyr Cys Phe Thr Ala Asn Lys Pro 
    210                 215                 220                 


Asp Gly Ser Ile Arg Trp Lys Ser Phe Ser Phe Val Arg Val Ile Ser 
225                 230                 235                 240 


Leu Gly Leu Val Val Phe Leu Val Ser Ala Leu Ser Leu Gly Pro Phe 
                245                 250                 255     


Leu Ala Leu Asn Gln Leu Pro Gln Val Phe Ser Arg Leu Phe Pro Phe 
            260                 265                 270         


Lys Arg Gly Leu Cys His Ala Tyr Trp Ala Pro Asn Phe Trp Ala Leu 
        275                 280                 285             


Tyr Asn Ala Leu Asp Lys Val Leu Ser Val Ile Gly Leu Lys Leu Lys 
    290                 295                 300                 


Phe Leu Asp Pro Asn Asn Ile Pro Lys Ala Ser Met Thr Ser Gly Leu 
305                 310                 315                 320 


Val Gln Gln Phe Gln His Thr Val Leu Pro Ser Val Thr Pro Leu Ala 
                325                 330                 335     


Thr Leu Ile Cys Thr Leu Ile Ala Ile Leu Pro Ser Ile Phe Cys Leu 
            340                 345                 350         


Trp Phe Lys Pro Gln Gly Pro Arg Gly Phe Leu Arg Cys Leu Thr Leu 
        355                 360                 365             


Cys Ala Leu Ser Ser Phe Met Phe Gly Trp His Val His Glu Lys Ala 
    370                 375                 380                 


Ile Leu Leu Ala Ile Leu Pro Met Ser Leu Leu Ser Val Gly Lys Ala 
385                 390                 395                 400 


Gly Asp Ala Ser Ile Phe Leu Ile Leu Thr Thr Thr Gly His Tyr Ser 
                405                 410                 415     


Leu Phe Pro Leu Leu Phe Thr Ala Pro Glu Leu Pro Ile Lys Ile Leu 
            420                 425                 430         


Leu Met Leu Leu Phe Thr Ile Tyr Ser Ile Ser Ser Leu Lys Thr Leu 
        435                 440                 445             


Phe Arg Arg Ser Phe Thr Leu Val Ala Gln Ala Gly Val Gln Trp His 
    450                 455                 460                 


Asp Leu Ser 
465         


<210>  501
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  501

Met Ser Leu Tyr Pro Ser Leu Glu Asp Leu Lys Val Asp Lys Val Ile 
1               5                   10                  15      


Gln Ala Gln Thr Ala Phe Ser Ala Asn Pro Ala Asn Pro Ala Ile Leu 
            20                  25                  30          


Ser Glu Ala Ser Ala Pro Ile Pro His Asp Gly Asn Leu Tyr Pro Arg 
        35                  40                  45              


Leu Tyr Pro Glu Leu Ser Gln Tyr Met Gly Leu Ser Leu Asn Glu Glu 
    50                  55                  60                  


Glu Ile Arg Ala Asn Val Ala Val Val Ser Gly Ala Pro Leu Gln Gly 
65                  70                  75                  80  


Gln Leu Val Ala Arg Pro Ser Ser Ile Asn Tyr Met Val Ala Pro Val 
                85                  90                  95      


Thr Gly Asn Asp Val Gly Ile Arg Arg Ala Glu Ile Lys Gln Gly Ile 
            100                 105                 110         


Arg Glu Val Ile Leu Cys Lys Asp Gln Asp Gly Lys Ile Gly Leu Arg 
        115                 120                 125             


Leu Lys Ser Ile Asp Asn Gly Ile Phe Val Gln Leu Val Gln Ala Asn 
    130                 135                 140                 


Ser Pro Ala Ser Leu Val Gly Leu Arg Phe Gly Asp Gln Val Leu Gln 
145                 150                 155                 160 


Ile Asn Gly Glu Asn Cys Ala Gly Trp Ser Ser Asp Lys Ala His Lys 
                165                 170                 175     


Val Leu Lys Gln Ala Phe Gly Glu Lys Ile Thr Met Thr Ile Arg Asp 
            180                 185                 190         


Arg Pro Phe Glu Arg Thr Ile Thr Met His Lys Asp Ser Thr Gly His 
        195                 200                 205             


Val Gly Phe Ile Phe Lys Asn Gly Lys Ile Thr Ser Ile Val Lys Asp 
    210                 215                 220                 


Ser Ser Ala Ala Arg Asn Gly Leu Leu Thr Glu His Asn Ile Cys Glu 
225                 230                 235                 240 


Ile Asn Gly Gln Asn Val Ile Gly Leu Lys Asp Ser Gln Ile Ala Asp 
                245                 250                 255     


Ile Leu Ser Thr Ser Gly Thr Val Val Thr Ile Thr Ile Met Pro Ala 
            260                 265                 270         


Phe Ile Phe Glu His Ile Ile Lys Arg Met Ala Pro Ser Ile Met Lys 
        275                 280                 285             


Ser Leu Met Asp His Thr Ile Pro Glu Val 
    290                 295             


<210>  502
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  502

Met Ser Leu Tyr Pro Ser Leu Glu Asp Leu Lys Ala Gln Thr Ala Phe 
1               5                   10                  15      


Ser Ala Asn Pro Ala Asn Pro Ala Ile Leu Ser Glu Ala Ser Ala Pro 
            20                  25                  30          


Ile Pro His Asp Gly Asn Leu Tyr Pro Arg Leu Tyr Pro Glu Leu Ser 
        35                  40                  45              


Gln Tyr Met Gly Leu Ser Leu Asn Glu Glu Glu Ile Arg Ala Asn Val 
    50                  55                  60                  


Ala Val Val Ser Gly Ala Pro Leu Gln Gly Gln Leu Val Ala Arg Pro 
65                  70                  75                  80  


Ser Ser Ile Asn Tyr Met Val Ala Pro Val Thr Gly Asn Asp Val Gly 
                85                  90                  95      


Ile Arg Arg Ala Glu Ile Lys Gln Gly Ile Arg Glu Val Ile Leu Cys 
            100                 105                 110         


Lys Asp Gln Asp Gly Lys Ile Gly Leu Arg Leu Lys Ser Ile Asp Asn 
        115                 120                 125             


Gly Ile Phe Val Gln Leu Val Gln Ala Asn Ser Pro Ala Ser Leu Val 
    130                 135                 140                 


Gly Leu Arg Phe Gly Asp Gln Val Leu Gln Ile Asn Gly Glu Asn Cys 
145                 150                 155                 160 


Ala Gly Trp Ser Ser Asp Lys Ala His Lys Val Leu Lys Gln Ala Phe 
                165                 170                 175     


Gly Glu Lys Ile Thr Met Thr Ile Arg Asp Arg Pro Phe Glu Arg Thr 
            180                 185                 190         


Ile Thr Met His Lys Asp Ser Thr Gly His Val Gly Phe Ile Phe Lys 
        195                 200                 205             


Asn Gly Lys Ile Thr Ser Ile Val Lys Asp Ser Ser Ala Ala Arg Asn 
    210                 215                 220                 


Gly Leu Leu Thr Glu His Asn Ile Cys Glu Ile Asn Gly Gln Asn Val 
225                 230                 235                 240 


Ile Gly Leu Lys Asp Ser Gln Ile Ala Asp Ile Leu Ser Thr Ser Gly 
                245                 250                 255     


Thr Val Val Thr Ile Thr Ile Met Pro Ala Phe Ile Phe Glu His Ile 
            260                 265                 270         


Ile Lys Arg Met Ala Pro Ser Ile Met Lys Ser Leu Met Asp His Thr 
        275                 280                 285             


Ile Pro Glu Val 
    290         


<210>  503
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  503

Met Ser Leu Tyr Pro Ser Leu Glu Asp Leu Lys Val Asp Lys Val Ile 
1               5                   10                  15      


Gln Ala Gln Thr Ala Phe Ser Ala Asn Pro Ala Asn Pro Ala Ile Leu 
            20                  25                  30          


Ser Glu Ala Ser Ala Pro Ile Pro His Asp Gly Asn Leu Tyr Pro Arg 
        35                  40                  45              


Leu Tyr Pro Glu Leu Ser Gln Tyr Met Gly Leu Ser Leu Asn Glu Glu 
    50                  55                  60                  


Glu Ile Arg Ala Asn Val Ala Val Val Ser Gly Ala Pro Leu Gln Gly 
65                  70                  75                  80  


Leu Val Ala Arg Pro Ser Ser Ile Asn Tyr Met Val Ala Pro Val Thr 
                85                  90                  95      


Gly Asn Asp Val Gly Ile Arg Arg Ala Glu Ile Lys Gln Gly Ile Arg 
            100                 105                 110         


Glu Val Ile Leu Cys Lys Asp Gln Asp Gly Lys Ile Gly Leu Arg Leu 
        115                 120                 125             


Lys Ser Ile Asp Asn Gly Ile Phe Val Gln Leu Val Gln Ala Asn Ser 
    130                 135                 140                 


Pro Ala Ser Leu Val Gly Leu Arg Phe Gly Asp Gln Val Leu Gln Ile 
145                 150                 155                 160 


Asn Gly Glu Asn Cys Ala Gly Trp Ser Ser Asp Lys Ala His Lys Val 
                165                 170                 175     


Leu Lys Gln Ala Phe Gly Glu Lys Ile Thr Met Thr Ile Arg Asp Arg 
            180                 185                 190         


Pro Phe Glu Arg Thr Ile Thr Met His Lys Asp Ser Thr Gly His Val 
        195                 200                 205             


Gly Phe Ile Phe Lys Asn Gly Lys Ile Thr Ser Ile Val Lys Asp Ser 
    210                 215                 220                 


Ser Ala Ala Arg Asn Gly Leu Leu Thr Glu His Asn Ile Cys Glu Ile 
225                 230                 235                 240 


Asn Gly Gln Asn Val Ile Gly Leu Lys Asp Ser Gln Ile Ala Asp Ile 
                245                 250                 255     


Leu Ser Thr Ser Gly Thr Val Val Thr Ile Thr Ile Met Pro Ala Phe 
            260                 265                 270         


Ile Phe Glu His Ile Ile Lys Arg Met Ala Pro Ser Ile Met Lys Ser 
        275                 280                 285             


Leu Met Asp His Thr Ile Pro Glu Val 
    290                 295         


<210>  504
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  504

Met Ser Leu Tyr Pro Ser Leu Glu Asp Leu Lys Val Asp Lys Val Ile 
1               5                   10                  15      


Gln Ala Gln Thr Ala Phe Ser Ala Asn Pro Ala Asn Pro Ala Ile Leu 
            20                  25                  30          


Ser Glu Ala Ser Ala Pro Ile Pro His Asp Gly Asn Leu Tyr Pro Arg 
        35                  40                  45              


Leu Tyr Pro Glu Leu Ser Gln Tyr Met Gly Leu Ser Leu Asn Glu Glu 
    50                  55                  60                  


Glu Ile Arg Ala Asn Val Ala Val Val Ser Gly Ala Pro Leu Gln Gly 
65                  70                  75                  80  


Leu Val Ala Arg Pro Ser Ser Ile Asn Tyr Met Val Ala Pro Val Thr 
                85                  90                  95      


Gly Asn Asp Val Gly Ile Arg Arg Ala Glu Ile Lys Gln Gly Ile Arg 
            100                 105                 110         


Glu Val Ile Leu Cys Lys Asp Gln Asp Gly Lys Ile Gly Leu Arg Leu 
        115                 120                 125             


Lys Ser Ile Asp Asn Gly Ile Phe Val Gln Leu Val Gln Ala Asn Ser 
    130                 135                 140                 


Pro Ala Ser Leu Val Gly Leu Arg Phe Gly Asp Gln Val Leu Gln Ile 
145                 150                 155                 160 


Asn Gly Glu Asn Cys Ala Gly Trp Ser Ser Asp Lys Ala His Lys Val 
                165                 170                 175     


Leu Lys Gln Ala Phe Gly Glu Lys Ile Thr Met Thr Ile Arg Asp Arg 
            180                 185                 190         


Pro Phe Glu Arg Thr Ile Thr Met His Lys Asp Ser Thr Gly His Val 
        195                 200                 205             


Gly Phe Ile Phe Lys Asn Gly Lys Ile Thr Ser Ile Val Lys Asp Ser 
    210                 215                 220                 


Ser Ala Ala Arg Asn Gly Leu Leu Thr Glu His Asn Ile Cys Glu Ile 
225                 230                 235                 240 


Asn Gly Gln Asn Val Ile Gly Leu Lys Asp Ser Gln Ile Ala Asp Ile 
                245                 250                 255     


Leu Ser Thr Ser Gly Thr Val Val Thr Ile Thr Ile Met Pro Ala Phe 
            260                 265                 270         


Ile Phe Glu His Ile Ile Lys Arg Met Ala Pro Ser Ile Met Lys Ser 
        275                 280                 285             


Leu Met Asp His Thr Ile Pro Glu Val 
    290                 295         


<210>  505
<211>  709
<212>  PRT
<213>  Homo sapiens

<400>  505

Met Ser Gly Ser Arg Lys Glu Phe Asp Val Lys Gln Ile Leu Lys Ile 
1               5                   10                  15      


Arg Trp Arg Trp Phe Gly His Gln Ala Ser Ser Pro Asn Ser Thr Val 
            20                  25                  30          


Asp Ser Gln Gln Gly Glu Phe Trp Asn Arg Gly Gln Thr Gly Ala Asn 
        35                  40                  45              


Gly Gly Arg Lys Phe Leu Asp Pro Cys Ser Leu Gln Leu Pro Leu Ala 
    50                  55                  60                  


Ser Ile Gly Tyr Arg Arg Ser Ser Gln Leu Asp Phe Gln Asn Ser Pro 
65                  70                  75                  80  


Ser Trp Pro Met Ala Ser Thr Ser Glu Val Pro Ala Phe Glu Phe Thr 
                85                  90                  95      


Ala Glu Asp Cys Gly Gly Ala His Trp Leu Asp Arg Pro Glu Val Asp 
            100                 105                 110         


Asp Gly Thr Ser Glu Glu Glu Asn Glu Ser Asp Ser Ser Ser Cys Arg 
        115                 120                 125             


Thr Ser Asn Ser Ser Gln Thr Leu Ser Ser Cys His Thr Met Glu Pro 
    130                 135                 140                 


Cys Thr Ser Asp Glu Phe Phe Gln Ala Leu Asn His Ala Glu Gln Thr 
145                 150                 155                 160 


Phe Lys Lys Met Glu Asn Tyr Leu Arg His Lys Gln Leu Cys Asp Val 
                165                 170                 175     


Ile Leu Val Ala Gly Asp Arg Arg Ile Pro Ala His Arg Leu Val Leu 
            180                 185                 190         


Ser Ser Val Ser Asp Tyr Phe Ala Ala Met Phe Thr Asn Asp Val Arg 
        195                 200                 205             


Glu Ala Arg Gln Glu Glu Ile Lys Met Glu Gly Val Glu Pro Asn Ser 
    210                 215                 220                 


Leu Trp Ser Leu Ile Gln Tyr Ala Tyr Thr Gly Arg Leu Glu Leu Lys 
225                 230                 235                 240 


Glu Asp Asn Ile Glu Cys Leu Leu Ser Thr Ala Cys Leu Leu Gln Leu 
                245                 250                 255     


Ser Gln Val Val Glu Ala Cys Cys Lys Phe Leu Met Lys Gln Leu His 
            260                 265                 270         


Pro Ser Asn Cys Leu Gly Ile Arg Ser Phe Ala Asp Ala Gln Gly Cys 
        275                 280                 285             


Thr Asp Leu His Lys Val Ala His Asn Tyr Thr Met Glu His Phe Met 
    290                 295                 300                 


Glu Val Ile Arg Asn Gln Glu Phe Val Leu Leu Pro Ala Ser Glu Ile 
305                 310                 315                 320 


Ala Lys Leu Leu Ala Ser Asp Asp Met Asn Ile Pro Asn Glu Glu Thr 
                325                 330                 335     


Ile Leu Asn Ala Leu Leu Thr Trp Val Arg His Asp Leu Glu Gln Arg 
            340                 345                 350         


Arg Lys Asp Leu Ser Lys Leu Leu Ala Tyr Ile Arg Leu Pro Leu Leu 
        355                 360                 365             


Ala Pro Gln Phe Leu Ala Asp Met Glu Asn Asn Val Leu Phe Arg Asp 
    370                 375                 380                 


Asp Ile Glu Cys Gln Lys Leu Ile Met Glu Ala Met Lys Tyr His Leu 
385                 390                 395                 400 


Leu Pro Glu Arg Arg Pro Met Leu Gln Ser Pro Arg Thr Lys Pro Arg 
                405                 410                 415     


Lys Ser Thr Val Gly Thr Leu Phe Ala Val Gly Gly Met Asp Ser Thr 
            420                 425                 430         


Lys Gly Ala Thr Ser Ile Glu Lys Tyr Asp Leu Arg Thr Asn Met Trp 
        435                 440                 445             


Thr Pro Val Ala Asn Met Asn Gly Arg Arg Leu Gln Phe Gly Val Ala 
    450                 455                 460                 


Val Leu Asp Asp Lys Leu Tyr Val Val Gly Gly Arg Asp Gly Leu Lys 
465                 470                 475                 480 


Thr Leu Asn Thr Val Glu Cys Tyr Asn Pro Lys Thr Lys Thr Trp Ser 
                485                 490                 495     


Val Met Pro Pro Met Ser Thr His Arg His Gly Leu Gly Val Ala Val 
            500                 505                 510         


Leu Glu Gly Pro Met Tyr Ala Val Gly Gly His Asp Gly Trp Ser Tyr 
        515                 520                 525             


Leu Asn Thr Val Glu Arg Trp Asp Pro Gln Ala Arg Gln Trp Asn Phe 
    530                 535                 540                 


Val Ala Thr Met Ser Thr Pro Arg Ser Thr Val Gly Val Ala Val Leu 
545                 550                 555                 560 


Ser Gly Lys Leu Tyr Ala Val Gly Gly Arg Asp Gly Ser Ser Cys Leu 
                565                 570                 575     


Lys Ser Val Glu Cys Phe Asp Pro His Thr Asn Lys Trp Thr Leu Cys 
            580                 585                 590         


Ala Gln Met Ser Lys Arg Arg Gly Gly Val Gly Val Thr Thr Trp Asn 
        595                 600                 605             


Gly Leu Leu Tyr Ala Ile Gly Gly His Asp Ala Pro Ala Ser Asn Leu 
    610                 615                 620                 


Thr Ser Arg Leu Ser Asp Cys Val Glu Arg Tyr Asp Pro Lys Thr Asp 
625                 630                 635                 640 


Met Trp Thr Ala Val Ala Ser Met Ser Ile Ser Arg Asp Ala Val Gly 
                645                 650                 655     


Val Cys Leu Leu Gly Asp Lys Leu Tyr Ala Val Gly Gly Tyr Asp Gly 
            660                 665                 670         


Gln Ala Tyr Leu Asn Thr Val Glu Ala Tyr Asp Pro Gln Thr Asn Glu 
        675                 680                 685             


Trp Thr Gln Val Ala Pro Leu Cys Leu Gly Arg Ala Gly Ala Cys Val 
    690                 695                 700                 


Val Thr Val Lys Leu 
705                 


<210>  506
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  506

Met Ser Ser Trp Ile Arg Trp His Gly Pro Ala Met Ala Arg Leu Trp 
1               5                   10                  15      


Gly Phe Cys Trp Leu Val Val Gly Phe Trp Arg Ala Ala Phe Ala Cys 
            20                  25                  30          


Pro Thr Ser Cys Lys Cys Ser Ala Ser Arg Ile Trp Cys Ser Asp Pro 
        35                  40                  45              


Ser Pro Gly Ile Val Ala Phe Pro Arg Leu Glu Pro Asn Ser Val Asp 
    50                  55                  60                  


Pro Glu Asn Ile Thr Glu Ile Phe Ile Ala Asn Gln Lys Arg Leu Glu 
65                  70                  75                  80  


Ile Ile Asn Glu Asp Asp Val Glu Ala Tyr Val Gly Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Asp Ser Gly Leu Lys Phe Val Ala His Lys Ala Phe Leu 
            100                 105                 110         


Lys Asn Ser Asn Leu Gln His Ile Asn Phe Thr Arg Asn Lys Leu Thr 
        115                 120                 125             


Ser Leu Ser Arg Lys His Phe Arg His Leu Asp Leu Ser Glu Leu Ile 
    130                 135                 140                 


Leu Val Gly Asn Pro Phe Thr Cys Ser Cys Asp Ile Met Trp Ile Lys 
145                 150                 155                 160 


Thr Leu Gln Glu Ala Lys Ser Ser Pro Asp Thr Gln Asp Leu Tyr Cys 
                165                 170                 175     


Leu Asn Glu Ser Ser Lys Asn Ile Pro Leu Ala Asn Leu Gln Ile Pro 
            180                 185                 190         


Asn Cys Gly Leu Pro Ser Ala Asn Leu Ala Ala Pro Asn Leu Thr Val 
        195                 200                 205             


Glu Glu Gly Lys Ser Ile Thr Leu Ser Cys Ser Val Ala Gly Asp Pro 
    210                 215                 220                 


Val Pro Asn Met Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His Met 
225                 230                 235                 240 


Asn Glu Thr Ser His Thr Gln Gly Ser Leu Arg Ile Thr Asn Ile Ser 
                245                 250                 255     


Ser Asp Asp Ser Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu Val 
            260                 265                 270         


Gly Glu Asp Gln Asp Ser Val Asn Leu Thr Val His Phe Ala Pro Thr 
        275                 280                 285             


Ile Thr Phe Leu Glu Ser Pro Thr Ser Asp His His Trp Cys Ile Pro 
    290                 295                 300                 


Phe Thr Val Lys Gly Asn Pro Lys Pro Ala Leu Gln Trp Phe Tyr Asn 
305                 310                 315                 320 


Gly Ala Ile Leu Asn Glu Ser Lys Tyr Ile Cys Thr Lys Ile His Val 
                325                 330                 335     


Thr Asn His Thr Glu Tyr His Gly Cys Leu Gln Leu Asp Asn Pro Thr 
            340                 345                 350         


His Met Asn Asn Gly Asp Tyr Thr Leu Ile Ala Lys Asn Glu Tyr Gly 
        355                 360                 365             


Lys Asp Glu Lys Gln Ile Ser Ala His Phe Met Gly Trp Pro Gly Ile 
    370                 375                 380                 


Asp Asp Gly Ala Asn Pro Asn Tyr Pro Asp Val Ile Tyr Glu Asp Tyr 
385                 390                 395                 400 


Gly Thr Ala Ala Asn Asp Ile Gly Asp Thr Thr Asn Arg Ser Asn Glu 
                405                 410                 415     


Ile Pro Ser Thr Asp Val Thr Asp Lys Thr Gly Arg Glu His Leu Ser 
            420                 425                 430         


Val Tyr Ala Val Val Val Ile Ala Ser Val Val Gly Phe Cys Leu Leu 
        435                 440                 445             


Val Met Leu Phe Leu Leu Lys Leu Ala Arg His Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Gly Phe Val Leu Phe His Lys Ile Pro Leu Asp Gly 
465                 470                 475         


<210>  507
<211>  612
<212>  PRT
<213>  Homo sapiens

<400>  507

Met Asp Val Ser Leu Cys Pro Ala Lys Cys Ser Phe Trp Arg Ile Phe 
1               5                   10                  15      


Leu Leu Gly Ser Val Trp Leu Asp Tyr Val Gly Ser Val Leu Ala Cys 
            20                  25                  30          


Pro Ala Asn Cys Val Cys Ser Lys Thr Glu Ile Asn Cys Arg Arg Pro 
        35                  40                  45              


Asp Asp Gly Asn Leu Phe Pro Leu Leu Glu Gly Gln Asp Ser Gly Asn 
    50                  55                  60                  


Ser Asn Gly Asn Ala Ser Ile Asn Ile Thr Asp Ile Ser Arg Asn Ile 
65                  70                  75                  80  


Thr Ser Ile His Ile Glu Asn Trp Arg Ser Leu His Thr Leu Asn Ala 
                85                  90                  95      


Val Asp Met Glu Leu Tyr Thr Gly Leu Gln Lys Leu Thr Ile Lys Asn 
            100                 105                 110         


Ser Gly Leu Arg Ser Ile Gln Pro Arg Ala Phe Ala Lys Asn Pro His 
        115                 120                 125             


Leu Arg Tyr Ile Asn Leu Ser Ser Asn Arg Leu Thr Thr Leu Ser Trp 
    130                 135                 140                 


Gln Leu Phe Gln Thr Leu Ser Leu Arg Glu Leu Gln Leu Glu Gln Asn 
145                 150                 155                 160 


Phe Phe Asn Cys Ser Cys Asp Ile Arg Trp Met Gln Leu Trp Gln Glu 
                165                 170                 175     


Gln Gly Glu Ala Lys Leu Asn Ser Gln Asn Leu Tyr Cys Ile Asn Ala 
            180                 185                 190         


Asp Gly Ser Gln Leu Pro Leu Phe Arg Met Asn Ile Ser Gln Cys Asp 
        195                 200                 205             


Leu Pro Glu Ile Ser Val Ser His Val Asn Leu Thr Val Arg Glu Gly 
    210                 215                 220                 


Asp Asn Ala Val Ile Thr Cys Asn Gly Ser Gly Ser Pro Leu Pro Asp 
225                 230                 235                 240 


Val Asp Trp Ile Val Thr Gly Leu Gln Ser Ile Asn Thr His Gln Thr 
                245                 250                 255     


Asn Leu Asn Trp Thr Asn Val His Ala Ile Asn Leu Thr Leu Val Asn 
            260                 265                 270         


Val Thr Ser Glu Asp Asn Gly Phe Thr Leu Thr Cys Ile Ala Glu Asn 
        275                 280                 285             


Val Val Gly Met Ser Asn Ala Ser Val Ala Leu Thr Val Tyr Tyr Pro 
    290                 295                 300                 


Pro Arg Val Val Ser Leu Glu Glu Pro Glu Leu Arg Leu Glu His Cys 
305                 310                 315                 320 


Ile Glu Phe Val Val Arg Gly Asn Pro Pro Pro Thr Leu His Trp Leu 
                325                 330                 335     


His Asn Gly Gln Pro Leu Arg Glu Ser Lys Ile Ile His Val Glu Tyr 
            340                 345                 350         


Tyr Gln Glu Gly Glu Ile Ser Glu Gly Cys Leu Leu Phe Asn Lys Pro 
        355                 360                 365             


Thr His Tyr Asn Asn Gly Asn Tyr Thr Leu Ile Ala Lys Asn Pro Leu 
    370                 375                 380                 


Gly Thr Ala Asn Gln Thr Ile Asn Gly His Phe Leu Lys Glu Pro Phe 
385                 390                 395                 400 


Pro Glu Ser Thr Asp Asn Phe Ile Leu Phe Asp Glu Val Ser Pro Thr 
                405                 410                 415     


Pro Pro Ile Thr Val Thr His Lys Pro Glu Glu Asp Thr Phe Gly Val 
            420                 425                 430         


Ser Ile Ala Val Gly Leu Ala Ala Phe Ala Cys Val Leu Leu Val Val 
        435                 440                 445             


Leu Phe Val Met Ile Asn Lys Tyr Gly Arg Arg Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Gly Pro Val Ala Val Ile Ser Gly Glu Glu Asp Ser Ala Ser Pro 
465                 470                 475                 480 


Leu His His Ile Asn His Gly Ile Thr Thr Pro Ser Ser Leu Asp Ala 
                485                 490                 495     


Gly Pro Asp Thr Val Val Ile Gly Met Thr Arg Ile Pro Val Ile Glu 
            500                 505                 510         


Asn Pro Gln Tyr Phe Arg Gln Gly His Asn Cys His Lys Pro Asp Thr 
        515                 520                 525             


Trp Val Phe Ser Asn Ile Asp Asn His Gly Ile Leu Asn Leu Lys Asp 
    530                 535                 540                 


Asn Arg Asp His Leu Val Pro Ser Thr His Tyr Ile Tyr Glu Glu Pro 
545                 550                 555                 560 


Glu Val Gln Ser Gly Glu Val Ser Tyr Pro Arg Ser His Gly Phe Arg 
                565                 570                 575     


Glu Ile Met Leu Asn Pro Ile Ser Leu Pro Gly His Ser Lys Pro Leu 
            580                 585                 590         


Asn His Gly Ile Tyr Val Glu Asp Val Asn Val Tyr Phe Ser Lys Gly 
        595                 600                 605             


Arg His Gly Phe 
    610         


<210>  508
<211>  1194
<212>  PRT
<213>  Homo sapiens

<400>  508

Met Lys Cys Phe Phe Pro Val Leu Ser Cys Leu Ala Val Leu Gly Val 
1               5                   10                  15      


Val Ser Ala Gln Arg Gln Val Thr Val Gln Glu Gly Pro Leu Tyr Arg 
            20                  25                  30          


Thr Glu Gly Ser His Ile Thr Ile Trp Cys Asn Val Ser Gly Tyr Gln 
        35                  40                  45              


Gly Pro Ser Glu Gln Asn Phe Gln Trp Ser Ile Tyr Leu Pro Ser Ser 
    50                  55                  60                  


Pro Glu Arg Glu Val Gln Ile Val Ser Thr Met Asp Ser Ser Phe Pro 
65                  70                  75                  80  


Tyr Ala Ile Tyr Thr Gln Arg Val Arg Gly Gly Lys Ile Phe Ile Glu 
                85                  90                  95      


Arg Val Gln Gly Asn Ser Thr Leu Leu His Ile Thr Asp Leu Gln Ala 
            100                 105                 110         


Arg Asp Ala Gly Glu Tyr Glu Cys His Thr Pro Ser Thr Asp Lys Gln 
        115                 120                 125             


Tyr Phe Gly Ser Tyr Ser Ala Lys Met Asn Leu Val Val Ile Pro Asp 
    130                 135                 140                 


Ser Leu Gln Thr Thr Ala Met Pro Gln Thr Leu His Arg Val Glu Gln 
145                 150                 155                 160 


Asp Pro Leu Glu Leu Thr Cys Glu Val Ala Ser Glu Thr Ile Gln His 
                165                 170                 175     


Ser His Leu Ser Val Ala Trp Leu Arg Gln Lys Val Gly Glu Lys Pro 
            180                 185                 190         


Val Glu Val Ile Ser Leu Ser Arg Asp Phe Met Leu His Ser Ser Ser 
        195                 200                 205             


Glu Tyr Ala Gln Arg Gln Ser Leu Gly Glu Val Arg Leu Asp Lys Leu 
    210                 215                 220                 


Gly Arg Thr Thr Phe Arg Leu Thr Ile Phe His Leu Gln Pro Ser Asp 
225                 230                 235                 240 


Gln Gly Glu Phe Tyr Cys Glu Ala Ala Glu Trp Ile Gln Asp Pro Asp 
                245                 250                 255     


Gly Ser Trp Tyr Ala Met Thr Arg Lys Arg Ser Glu Gly Ala Val Val 
            260                 265                 270         


Asn Val Gln Pro Thr Asp Lys Glu Phe Thr Val Arg Leu Glu Thr Glu 
        275                 280                 285             


Lys Arg Leu His Thr Val Gly Glu Pro Val Glu Phe Arg Cys Ile Leu 
    290                 295                 300                 


Glu Ala Gln Asn Val Pro Asp Arg Tyr Phe Ala Val Ser Trp Ala Phe 
305                 310                 315                 320 


Asn Ser Ser Leu Ile Ala Thr Met Gly Pro Asn Ala Val Pro Val Leu 
                325                 330                 335     


Asn Ser Glu Phe Ala His Arg Glu Ala Arg Gly Gln Leu Lys Val Ala 
            340                 345                 350         


Lys Glu Ser Asp Ser Val Phe Val Leu Lys Ile Tyr His Leu Arg Gln 
        355                 360                 365             


Glu Asp Ser Gly Lys Tyr Asn Cys Arg Val Thr Glu Arg Glu Lys Thr 
    370                 375                 380                 


Val Thr Gly Glu Phe Ile Asp Lys Glu Ser Lys Arg Pro Lys Asn Ile 
385                 390                 395                 400 


Pro Ile Ile Val Leu Pro Leu Lys Ser Ser Ile Ser Val Glu Val Ala 
                405                 410                 415     


Ser Asn Ala Ser Val Ile Leu Glu Gly Glu Asp Leu Arg Phe Ser Cys 
            420                 425                 430         


Ser Val Arg Thr Ala Gly Arg Pro Gln Gly Arg Phe Ser Val Ile Trp 
        435                 440                 445             


Gln Leu Val Asp Arg Gln Asn Arg Arg Ser Asn Ile Met Trp Leu Asp 
    450                 455                 460                 


Arg Asp Gly Thr Val Gln Pro Gly Ser Ser Tyr Trp Glu Arg Ser Ser 
465                 470                 475                 480 


Phe Gly Gly Val Gln Met Glu Gln Val Gln Pro Asn Ser Phe Ser Leu 
                485                 490                 495     


Gly Ile Phe Asn Ser Arg Lys Glu Asp Glu Gly Gln Tyr Glu Cys His 
            500                 505                 510         


Val Thr Glu Trp Val Arg Ala Val Asp Gly Glu Trp Gln Ile Val Gly 
        515                 520                 525             


Glu Arg Arg Ala Ser Thr Pro Ile Ser Ile Thr Ala Leu Glu Met Gly 
    530                 535                 540                 


Phe Ala Val Thr Ala Ile Ser Arg Thr Pro Gly Val Thr Tyr Ser Asp 
545                 550                 555                 560 


Ser Phe Asp Leu Gln Cys Ile Ile Lys Pro His Tyr Pro Ala Trp Val 
                565                 570                 575     


Pro Val Ser Val Thr Trp Arg Phe Gln Pro Val Gly Thr Val Glu Phe 
            580                 585                 590         


His Asp Leu Val Thr Phe Thr Arg Asp Gly Gly Val Gln Trp Gly Asp 
        595                 600                 605             


Arg Ser Ser Ser Phe Arg Thr Arg Thr Ala Ile Glu Lys Ala Glu Ser 
    610                 615                 620                 


Ser Asn Asn Val Arg Leu Ser Ile Ser Arg Ala Ser Asp Thr Glu Ala 
625                 630                 635                 640 


Gly Lys Tyr Gln Cys Val Ala Glu Leu Trp Arg Lys Asn Tyr Asn Asn 
                645                 650                 655     


Thr Trp Thr Arg Leu Ala Glu Arg Thr Ser Asn Leu Leu Glu Ile Arg 
            660                 665                 670         


Val Leu Gln Pro Val Thr Lys Leu Gln Val Ser Lys Ser Lys Arg Thr 
        675                 680                 685             


Leu Thr Leu Val Glu Asn Lys Pro Ile Gln Leu Asn Cys Ser Val Lys 
    690                 695                 700                 


Ser Gln Thr Ser Gln Asn Ser His Phe Ala Val Leu Trp Tyr Val His 
705                 710                 715                 720 


Lys Pro Ser Asp Ala Asp Gly Lys Leu Ile Leu Lys Thr Thr His Asn 
                725                 730                 735     


Ser Ala Phe Glu Tyr Gly Thr Tyr Ala Glu Glu Glu Gly Leu Arg Ala 
            740                 745                 750         


Arg Leu Gln Phe Glu Arg His Val Ser Gly Gly Leu Phe Ser Leu Thr 
        755                 760                 765             


Val Gln Arg Ala Glu Val Ser Asp Ser Gly Ser Tyr Tyr Cys His Val 
    770                 775                 780                 


Glu Glu Trp Leu Leu Ser Pro Asn Tyr Ala Trp Tyr Lys Leu Ala Glu 
785                 790                 795                 800 


Glu Val Ser Gly Arg Thr Glu Val Thr Val Lys Gln Pro Asp Ser Arg 
                805                 810                 815     


Leu Arg Leu Ser Gln Ala Gln Gly Asn Leu Ser Val Leu Glu Thr Arg 
            820                 825                 830         


Gln Val Gln Leu Glu Cys Val Val Leu Asn Arg Thr Ser Ile Thr Ser 
        835                 840                 845             


Gln Leu Met Val Glu Trp Phe Val Trp Lys Pro Asn His Pro Glu Arg 
    850                 855                 860                 


Glu Thr Val Ala Arg Leu Ser Arg Asp Ala Thr Phe His Tyr Gly Glu 
865                 870                 875                 880 


Gln Ala Ala Lys Asn Asn Leu Lys Gly Arg Leu His Leu Glu Ser Pro 
                885                 890                 895     


Ser Pro Gly Val Tyr Arg Leu Phe Ile Gln Asn Val Ala Val Gln Asp 
            900                 905                 910         


Ser Gly Thr Tyr Ser Cys His Val Glu Glu Trp Leu Pro Ser Pro Ser 
        915                 920                 925             


Gly Met Trp Tyr Lys Arg Ala Glu Asp Thr Ala Gly Gln Thr Ala Leu 
    930                 935                 940                 


Thr Val Met Arg Pro Asp Ala Ser Leu Gln Val Asp Thr Val Val Pro 
945                 950                 955                 960 


Asn Ala Thr Val Ser Glu Lys Ala Ala Phe Gln Leu Asp Cys Ser Ile 
                965                 970                 975     


Val Ser Arg Ser Ser Gln Asp Ser Arg Phe Ala Val Ala Trp Tyr Ser 
            980                 985                 990         


Leu Arg Thr Lys Ala Gly Gly Lys  Arg Ser Ser Pro Gly  Leu Glu Glu 
        995                 1000                 1005             


Gln Glu  Glu Glu Arg Glu Glu  Glu Glu Glu Glu Asp  Asp Asp Asp 
    1010                 1015                 1020             


Asp Asp  Asp Pro Thr Glu Arg  Thr Ala Leu Leu Ser  Val Gly Pro 
    1025                 1030                 1035             


Asp Ala  Val Phe Gly Pro Glu  Gly Ser Pro Trp Glu  Gly Arg Leu 
    1040                 1045                 1050             


Arg Phe  Gln Arg Leu Ser Pro  Val Leu Tyr Arg Leu  Thr Val Leu 
    1055                 1060                 1065             


Gln Ala  Ser Pro Gln Asp Thr  Gly Asn Tyr Ser Cys  His Val Glu 
    1070                 1075                 1080             


Glu Trp  Leu Pro Ser Pro Gln  Lys Glu Trp Tyr Arg  Leu Thr Glu 
    1085                 1090                 1095             


Glu Glu  Ser Ala Pro Ile Gly  Ile Arg Val Leu Asp  Thr Ser Pro 
    1100                 1105                 1110             


Thr Leu  Gln Ser Ile Ile Cys  Ser Asn Asp Ala Leu  Phe Tyr Phe 
    1115                 1120                 1125             


Val Phe  Phe Tyr Pro Phe Pro  Ile Phe Gly Ile Leu  Ile Ile Thr 
    1130                 1135                 1140             


Ile Leu  Leu Val Arg Phe Lys  Ser Arg Asn Ser Ser  Lys Asn Ser 
    1145                 1150                 1155             


Asp Gly  Lys Asn Gly Val Pro  Leu Leu Trp Ile Lys  Glu Pro His 
    1160                 1165                 1170             


Leu Asn  Tyr Ser Pro Thr Cys  Leu Glu Pro Pro Val  Leu Ser Ile 
    1175                 1180                 1185             


His Pro  Gly Ala Ile Asp 
    1190                 


<210>  509
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  509

Met Pro His Leu Met Glu Arg Met Val Gly Ser Gly Leu Leu Trp Leu 
1               5                   10                  15      


Ala Leu Val Ser Cys Ile Leu Thr Gln Ala Ser Ala Val Gln Arg Gly 
            20                  25                  30          


Tyr Gly Asn Pro Ile Glu Ala Ser Ser Tyr Gly Leu Asp Leu Asp Cys 
        35                  40                  45              


Gly Ala Pro Gly Thr Pro Glu Ala His Val Cys Phe Asp Pro Cys Gln 
    50                  55                  60                  


Asn Tyr Thr Leu Leu Asp Glu Pro Phe Arg Ser Thr Glu Asn Ser Ala 
65                  70                  75                  80  


Gly Ser Gln Gly Cys Asp Lys Asn Met Ser Gly Trp Tyr Arg Phe Val 
                85                  90                  95      


Gly Glu Gly Gly Val Arg Met Ser Glu Thr Cys Val Gln Val His Arg 
            100                 105                 110         


Cys Gln Thr Asp Ala Pro Met Trp Leu Asn Gly Thr His Pro Ala Leu 
        115                 120                 125             


Gly Asp Gly Ile Thr Asn His Thr Ala Cys Ala His Trp Ser Gly Asn 
    130                 135                 140                 


Cys Cys Phe Trp Lys Thr Glu Val Leu Val Lys Ala Cys Pro Gly Gly 
145                 150                 155                 160 


Tyr His Val Tyr Arg Leu Glu Gly Thr Pro Trp Cys Asn Leu Arg Tyr 
                165                 170                 175     


Cys Thr Val Pro Arg Asp Pro Ser Thr Val Glu Asp Lys Cys Glu Lys 
            180                 185                 190         


Ala Cys Arg Pro Glu Glu Glu Cys Leu Ala Leu Asn Ser Thr Trp Gly 
        195                 200                 205             


Cys Phe Cys Arg Gln Asp Leu Asn Ser Ser Asp Val His Ser Leu Gln 
    210                 215                 220                 


Pro Gln Leu Asp Cys Gly Pro Arg Glu Ile Lys Val Lys Val Asp Lys 
225                 230                 235                 240 


Cys Leu Leu Gly Gly Leu Gly Leu Gly Glu Glu Val Ile Ala Tyr Leu 
                245                 250                 255     


Arg Asp Pro Asn Cys Ser Ser Ile Leu Gln Thr Glu Glu Arg Asn Trp 
            260                 265                 270         


Val Ser Val Thr Ser Pro Val Gln Ala Ser Ala Cys Arg Asn Ile Leu 
        275                 280                 285             


Glu Arg Asn Gln Thr His Ala Ile Tyr Lys Asn Thr Leu Ser Leu Val 
    290                 295                 300                 


Asn Asp Phe Ile Ile Arg Asp Thr Ile Leu Asn Ile Asn Phe Gln Cys 
305                 310                 315                 320 


Ala Tyr Pro Leu Asp Met Lys Val Ser Leu Gln Ala Ala Leu Gln Pro 
                325                 330                 335     


Ile Val Ser Ser Leu Asn Val Ser Val Asp Gly Asn Gly Glu Phe Ile 
            340                 345                 350         


Val Arg Met Ala Leu Phe Gln Asp Gln Asn Tyr Thr Asn Pro Tyr Glu 
        355                 360                 365             


Gly Asp Ala Val Glu Leu Ser Val Glu Ser Val Leu Tyr Val Gly Ala 
    370                 375                 380                 


Ile Leu Glu Gln Gly Asp Thr Ser Arg Phe Asn Leu Val Leu Arg Asn 
385                 390                 395                 400 


Cys Tyr Ala Thr Pro Thr Glu Asp Lys Ala Asp Leu Val Lys Tyr Phe 
                405                 410                 415     


Ile Ile Arg Asn Ser Cys Ser Asn Gln Arg Asp Ser Thr Ile His Val 
            420                 425                 430         


Glu Glu Asn Gly Gln Ser Ser Glu Ser Arg Phe Ser Val Gln Met Phe 
        435                 440                 445             


Met Phe Ala Gly His Tyr Asp Leu Val Phe Leu His Cys Glu Ile His 
    450                 455                 460                 


Leu Cys Asp Ser Leu Asn Glu Gln Cys Gln Pro Ser Cys Ser Arg Ser 
465                 470                 475                 480 


Gln Val Arg Ser Glu Val Pro Ala Ile Asp Leu Ala Arg Val Leu Asp 
                485                 490                 495     


Leu Gly Pro Ile Thr Arg Arg Gly Ala Gln Ser Pro Gly Val Met Asn 
            500                 505                 510         


Gly Thr Pro Ser Thr Ala Gly Phe Leu Val Ala Trp Pro Met Val Leu 
        515                 520                 525             


Leu Thr Val Leu Leu Ala Trp Leu Phe 
    530                 535         


<210>  510
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  510

Met Pro His Leu Met Glu Arg Met Val Gly Ser Gly Leu Leu Trp Leu 
1               5                   10                  15      


Ala Leu Val Ser Cys Ile Leu Thr Gln Ala Ser Ala Val Gln Arg Val 
            20                  25                  30          


Pro Arg Asp Pro Ser Thr Val Glu Asp Lys Cys Glu Lys Ala Cys Arg 
        35                  40                  45              


Pro Glu Glu Glu Cys Leu Ala Leu Asn Ser Thr Trp Gly Cys Phe Cys 
    50                  55                  60                  


Arg Gln Asp Leu Asn Ser Ser Asp Val His Ser Leu Gln Pro Gln Leu 
65                  70                  75                  80  


Asp Cys Gly Pro Arg Glu Ile Lys Val Lys Val Asp Lys Cys Leu Leu 
                85                  90                  95      


Gly Gly Leu Gly Leu Gly Glu Glu Val Ile Ala Tyr Leu Arg Asp Pro 
            100                 105                 110         


Asn Cys Ser Ser Ile Leu Gln Thr Glu Glu Arg Asn Trp Val Ser Val 
        115                 120                 125             


Thr Ser Pro Val Gln Ala Ser Ala Cys Arg Asn Ile Leu Glu Arg Asn 
    130                 135                 140                 


Gln Thr His Ala Ile Tyr Lys Asn Thr Leu Ser Leu Val Asn Asp Phe 
145                 150                 155                 160 


Ile Ile Arg Asp Thr Ile Leu Asn Ile Asn Phe Gln Cys Ala Tyr Pro 
                165                 170                 175     


Leu Asp Met Lys Val Ser Leu Gln Ala Ala Leu Gln Pro Ile Val Ser 
            180                 185                 190         


Ser Leu Asn Val Ser Val Asp Gly Asn Gly Glu Phe Ile Val Arg Met 
        195                 200                 205             


Ala Leu Phe Gln Asp Gln Asn Tyr Thr Asn Pro Tyr Glu Gly Asp Ala 
    210                 215                 220                 


Val Glu Leu Ser Val Glu Ser Val Leu Tyr Val Gly Ala Ile Leu Glu 
225                 230                 235                 240 


Gln Gly Asp Thr Ser Arg Phe Asn Leu Val Leu Arg Asn Cys Tyr Ala 
                245                 250                 255     


Thr Pro Thr Glu Asp Lys Ala Asp Leu Val Lys Tyr Phe Ile Ile Arg 
            260                 265                 270         


Asn Ser Cys Ser Asn Gln Arg Asp Ser Thr Ile His Val Glu Glu Asn 
        275                 280                 285             


Gly Gln Ser Ser Glu Ser Arg Phe Ser Val Gln Met Phe Met Phe Ala 
    290                 295                 300                 


Gly His Tyr Asp Leu Val Phe Leu His Cys Glu Ile His Leu Cys Asp 
305                 310                 315                 320 


Ser Leu Asn Glu Gln Cys Gln Pro Ser Cys Ser Arg Ser Gln Val Arg 
                325                 330                 335     


Ser Glu Val Pro Ala Ile Asp Leu Ala Arg Val Leu Asp Leu Gly Pro 
            340                 345                 350         


Ile Thr Arg Arg Gly Ala Gln Ser Pro Gly Val Met Asn Gly Thr Pro 
        355                 360                 365             


Ser Thr Ala Gly Phe Leu Val Ala Trp Pro Met Val Leu Leu Thr Val 
    370                 375                 380                 


Leu Leu Ala Trp Leu Phe 
385                 390 


<210>  511
<211>  387
<212>  PRT
<213>  Homo sapiens

<400>  511

Met Pro His Leu Met Glu Arg Met Val Gly Ser Gly Leu Leu Trp Leu 
1               5                   10                  15      


Ala Leu Val Ser Cys Ile Leu Thr Gln Ala Ser Ala Val Gln Arg Asp 
            20                  25                  30          


Pro Ser Thr Val Glu Asp Lys Cys Glu Lys Ala Cys Arg Pro Glu Glu 
        35                  40                  45              


Glu Cys Leu Ala Leu Asn Ser Thr Trp Gly Cys Phe Cys Arg Gln Asp 
    50                  55                  60                  


Leu Asn Ser Ser Asp Val His Ser Leu Gln Pro Gln Leu Asp Cys Gly 
65                  70                  75                  80  


Pro Arg Glu Ile Lys Val Lys Val Asp Lys Cys Leu Leu Gly Gly Leu 
                85                  90                  95      


Gly Leu Gly Glu Glu Val Ile Ala Tyr Leu Arg Asp Pro Asn Cys Ser 
            100                 105                 110         


Ser Ile Leu Gln Thr Glu Glu Arg Asn Trp Val Ser Val Thr Ser Pro 
        115                 120                 125             


Val Gln Ala Ser Ala Cys Arg Asn Ile Leu Glu Arg Asn Gln Thr His 
    130                 135                 140                 


Ala Ile Tyr Lys Asn Thr Leu Ser Leu Val Asn Asp Phe Ile Ile Arg 
145                 150                 155                 160 


Asp Thr Ile Leu Asn Ile Asn Phe Gln Cys Ala Tyr Pro Leu Asp Met 
                165                 170                 175     


Lys Val Ser Leu Gln Ala Ala Leu Gln Pro Ile Val Ser Ser Leu Asn 
            180                 185                 190         


Val Ser Val Asp Gly Asn Gly Glu Phe Ile Val Arg Met Ala Leu Phe 
        195                 200                 205             


Gln Asp Gln Asn Tyr Thr Asn Pro Tyr Glu Gly Asp Ala Val Glu Leu 
    210                 215                 220                 


Ser Val Glu Ser Val Leu Tyr Val Gly Ala Ile Leu Glu Gln Gly Asp 
225                 230                 235                 240 


Thr Ser Arg Phe Asn Leu Val Leu Arg Asn Cys Tyr Ala Thr Pro Thr 
                245                 250                 255     


Glu Asp Lys Ala Asp Leu Val Lys Tyr Phe Ile Ile Arg Asn Ser Cys 
            260                 265                 270         


Ser Asn Gln Arg Asp Ser Thr Ile His Val Glu Glu Asn Gly Gln Ser 
        275                 280                 285             


Ser Glu Ser Arg Phe Ser Val Gln Met Phe Met Phe Ala Gly His Tyr 
    290                 295                 300                 


Asp Leu Val Phe Leu His Cys Glu Ile His Leu Cys Asp Ser Leu Asn 
305                 310                 315                 320 


Glu Gln Cys Gln Pro Ser Cys Ser Arg Ser Gln Val Arg Ser Glu Val 
                325                 330                 335     


Pro Ala Ile Asp Leu Ala Arg Val Leu Asp Leu Gly Pro Ile Thr Arg 
            340                 345                 350         


Arg Gly Ala Gln Ser Pro Gly Val Met Asn Gly Thr Pro Ser Thr Ala 
        355                 360                 365             


Gly Phe Leu Val Ala Trp Pro Met Val Leu Leu Thr Val Leu Leu Ala 
    370                 375                 380                 


Trp Leu Phe 
385         


<210>  512
<211>  1324
<212>  PRT
<213>  Homo sapiens

<400>  512

Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro 
1               5                   10                  15      


Arg Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro Glu Arg Leu 
            20                  25                  30          


Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu 
        35                  40                  45              


Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys 
    50                  55                  60                  


Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly 
65                  70                  75                  80  


Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala 
                85                  90                  95      


Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser 
            100                 105                 110         


Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr 
        115                 120                 125             


Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr 
    130                 135                 140                 


Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu 
145                 150                 155                 160 


Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His Gly Met 
                165                 170                 175     


Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys 
            180                 185                 190         


Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser 
        195                 200                 205             


Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser 
    210                 215                 220                 


Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His 
225                 230                 235                 240 


Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala 
                245                 250                 255     


His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp 
            260                 265                 270         


Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys Thr Val 
        275                 280                 285             


Glu Val Trp Met Gly Leu Asn Gln Leu Asp Glu His Ala Gly Trp Gln 
    290                 295                 300                 


Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val 
305                 310                 315                 320 


Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe 
                325                 330                 335     


Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr 
            340                 345                 350         


Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val Glu Lys 
        355                 360                 365             


Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro 
    370                 375                 380                 


Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp His 
385                 390                 395                 400 


Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile Asp Ile 
                405                 410                 415     


Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu 
            420                 425                 430         


Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val 
        435                 440                 445             


Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn Trp His 
    450                 455                 460                 


Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser 
465                 470                 475                 480 


Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu Glu Arg 
                485                 490                 495     


Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser Asp Ala Glu 
            500                 505                 510         


Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys 
        515                 520                 525             


Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly Tyr Tyr 
    530                 535                 540                 


Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln Ala Phe 
545                 550                 555                 560 


Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp Ser Tyr Phe 
                565                 570                 575     


Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys 
            580                 585                 590         


Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp Asn Thr 
        595                 600                 605             


His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly Arg His 
    610                 615                 620                 


Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys Ala Met 
625                 630                 635                 640 


Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala Glu Tyr Glu 
                645                 650                 655     


Glu Arg Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser Glu Pro 
            660                 665                 670         


Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met 
        675                 680                 685             


Lys Arg Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala 
    690                 695                 700                 


His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu 
705                 710                 715                 720 


Leu Leu His Ser Lys Phe Asn Trp Thr Glu Glu Arg Gln Phe Trp Ile 
                725                 730                 735     


Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu Trp Ser 
            740                 745                 750         


Asp Arg Thr Pro Val Val Ser Ser Phe Leu Asp Asn Thr Tyr Phe Gly 
        755                 760                 765             


Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu 
    770                 775                 780                 


Pro Leu His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile Pro Arg 
785                 790                 795                 800 


Asp Val Lys Pro Lys Ile Pro Phe Trp Tyr Gln Tyr Asp Val Pro Trp 
                805                 810                 815     


Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Thr Phe Ala Ser Glu 
            820                 825                 830         


Trp Leu Asn Phe Glu Phe Val Cys Ser Trp Leu His Ser Asp Leu Leu 
        835                 840                 845             


Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser Lys Ile Lys 
    850                 855                 860                 


Ala Leu Ser Lys Tyr Gly Ala Ser Trp Trp Ile Gly Leu Gln Glu Glu 
865                 870                 875                 880 


Arg Ala Asn Asp Glu Phe Arg Trp Arg Asp Gly Thr Pro Val Ile Tyr 
                885                 890                 895     


Gln Asn Trp Asp Thr Gly Arg Glu Arg Thr Val Asn Asn Gln Ser Gln 
            900                 905                 910         


Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly Ser Glu Glu 
        915                 920                 925             


Cys Ser Val Ser Met Pro Ser Ile Cys Lys Arg Lys Lys Val Trp Leu 
    930                 935                 940                 


Ile Glu Lys Lys Lys Asp Thr Pro Lys Gln His Gly Thr Cys Pro Lys 
945                 950                 955                 960 


Gly Trp Leu Tyr Phe Asn Tyr Lys Cys Leu Leu Leu Asn Ile Pro Lys 
                965                 970                 975     


Asp Pro Ser Ser Trp Lys Asn Trp Thr His Ala Gln His Phe Cys Ala 
            980                 985                 990         


Glu Glu Gly Gly Thr Leu Val Ala  Ile Glu Ser Glu Val  Glu Gln Ala 
        995                 1000                 1005             


Phe Ile  Thr Met Asn Leu Phe  Gly Gln Thr Thr Ser  Val Trp Ile 
    1010                 1015                 1020             


Gly Leu  Gln Asn Asp Asp Tyr  Glu Thr Trp Leu Asn  Gly Lys Pro 
    1025                 1030                 1035             


Val Val  Tyr Ser Asn Trp Ser  Pro Phe Asp Ile Ile  Asn Ile Pro 
    1040                 1045                 1050             


Ser His  Asn Thr Thr Glu Val  Gln Lys His Ile Pro  Leu Cys Ala 
    1055                 1060                 1065             


Leu Leu  Ser Ser Asn Pro Asn  Phe His Phe Thr Gly  Lys Trp Tyr 
    1070                 1075                 1080             


Phe Glu  Asp Cys Gly Lys Glu  Gly Tyr Gly Phe Val  Cys Glu Lys 
    1085                 1090                 1095             


Met Gln  Asp Thr Ser Gly His  Gly Val Asn Thr Ser  Asp Met Tyr 
    1100                 1105                 1110             


Pro Met  Pro Asn Thr Leu Glu  Tyr Gly Asn Arg Thr  Tyr Lys Ile 
    1115                 1120                 1125             


Ile Asn  Ala Asn Met Thr Trp  Tyr Ala Ala Ile Lys  Thr Cys Leu 
    1130                 1135                 1140             


Met His  Lys Ala Gln Leu Val  Ser Ile Thr Asp Gln  Tyr His Gln 
    1145                 1150                 1155             


Ser Phe  Leu Thr Val Val Leu  Asn Arg Leu Gly Tyr  Ala His Trp 
    1160                 1165                 1170             


Ile Gly  Leu Phe Thr Thr Asp  Asn Gly Leu Asn Phe  Asp Trp Ser 
    1175                 1180                 1185             


Asp Gly  Thr Lys Ser Ser Phe  Thr Phe Trp Lys Asp  Glu Glu Ser 
    1190                 1195                 1200             


Ser Leu  Leu Gly Asp Cys Val  Phe Ala Asp Ser Asn  Gly Arg Trp 
    1205                 1210                 1215             


His Ser  Thr Ala Cys Glu Ser  Phe Leu Gln Gly Ala  Ile Cys His 
    1220                 1225                 1230             


Val Pro  Pro Glu Thr Arg Gln  Ser Glu His Pro Glu  Leu Cys Ser 
    1235                 1240                 1245             


Glu Thr  Ser Ile Pro Trp Ile  Lys Phe Lys Ser Asn  Cys Tyr Ser 
    1250                 1255                 1260             


Phe Ser  Thr Val Leu Asp Ser  Met Ser Phe Glu Ala  Ala His Glu 
    1265                 1270                 1275             


Phe Cys  Lys Lys Glu Gly Ser  Asn Leu Leu Thr Ile  Lys Asp Glu 
    1280                 1285                 1290             


Ala Glu  Asn Ala Phe Leu Leu  Glu Glu Leu Phe Ala  Phe Gly Ser 
    1295                 1300                 1305             


Ser Val  Gln Met Val Trp Leu  Asn Ala Gln Phe Asp  Gly Asn Ser 
    1310                 1315                 1320             


Lys 
    


<210>  513
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  513

Met Ala Glu Thr Ser Leu Pro Glu Leu Gly Gly Glu Asp Lys Ala Thr 
1               5                   10                  15      


Pro Cys Pro Ser Ile Leu Glu Leu Glu Glu Leu Leu Arg Ala Gly Lys 
            20                  25                  30          


Ser Ser Cys Ser Arg Val Asp Glu Val Trp Pro Asn Leu Phe Ile Gly 
        35                  40                  45              


Asp Ala Ala Thr Ala Asn Asn Arg Phe Glu Leu Trp Lys Leu Gly Ile 
    50                  55                  60                  


Thr His Val Leu Asn Ala Ala His Lys Gly Leu Tyr Cys Gln Gly Gly 
65                  70                  75                  80  


Pro Asp Phe Tyr Gly Ser Ser Val Ser Tyr Leu Gly Val Pro Ala His 
                85                  90                  95      


Asp Leu Pro Asp Phe Asp Ile Ser Ala Tyr Phe Ser Ser Ala Ala Asp 
            100                 105                 110         


Phe Ile His Arg Ala Leu Asn Thr Pro Gly Ala Lys Val Leu Val His 
        115                 120                 125             


Cys Val Val Gly Val Ser Arg Ser Ala Thr Leu Val Leu Ala Tyr Leu 
    130                 135                 140                 


Met Leu His Gln Arg Leu Ser Leu Arg Gln Ala Val Ile Thr Val Arg 
145                 150                 155                 160 


Gln His Arg Trp Val Phe Pro Asn Arg Gly Phe Leu His Gln Leu Cys 
                165                 170                 175     


Arg Leu Asp Gln Gln Leu Arg Gly Ala Gly Gln Ser 
            180                 185             


<210>  514
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  514

Met Ala Glu Thr Ser Leu Pro Glu Leu Gly Gly Glu Asp Lys Ala Thr 
1               5                   10                  15      


Pro Cys Pro Ser Ile Leu Glu Leu Glu Glu Leu Leu Arg Ala Gly Lys 
            20                  25                  30          


Ser Ser Cys Ser Arg Val Asp Glu Val Trp Pro Asn Leu Phe Ile Gly 
        35                  40                  45              


Asp Ala Met Asp Ser Leu Gln Lys Gln Asp Leu Arg Arg Pro Lys Ile 
    50                  55                  60                  


His Gly Ala Val Gln Ala Ser Pro Tyr Gln Pro Pro Thr Leu Ala Ser 
65                  70                  75                  80  


Leu Gln Arg Leu Leu Trp Val Arg Gln Ala Ala Thr Leu Asn His Ile 
                85                  90                  95      


Asp Glu Val Trp Pro Ser Leu Phe Leu Gly Asp Ala Tyr Ala Ala Arg 
            100                 105                 110         


Asp Lys Ser Lys Leu Ile Gln Leu Gly Ile Thr His Val Val Asn Ala 
        115                 120                 125             


Ala Ala Gly Lys Phe Gln Val Asp Thr Gly Ala Lys Phe Tyr Arg Gly 
    130                 135                 140                 


Met Ser Leu Glu Tyr Tyr Gly Ile Glu Ala Asp Asp Asn Pro Phe Phe 
145                 150                 155                 160 


Asp Leu Ser Val Tyr Phe Leu Pro Val Ala Arg Tyr Ile Arg Ala Ala 
                165                 170                 175     


Leu Ser Val Pro Gln Gly Arg Val Leu Val His Cys Ala Met Gly Val 
            180                 185                 190         


Ser Arg Ser Ala Thr Leu Val Leu Ala Phe Leu Met Ile Cys Glu Asn 
        195                 200                 205             


Met Thr Leu Val Glu Ala Ile Gln Thr Val Gln Ala His Arg Asn Ile 
    210                 215                 220                 


Cys Pro Asn Ser Gly Phe Leu Arg Gln Leu Gln Val Leu Asp Asn Arg 
225                 230                 235                 240 


Leu Gly Arg Glu Thr Gly Arg Phe 
                245             


<210>  515
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  515

Met Gly Leu Cys His Phe Ala Thr Leu Ala Leu Ile Leu Leu Val Leu 
1               5                   10                  15      


Leu Glu Ala Leu Ala Gln Ala Asp Thr Gln Lys Met Val Glu Ala Gln 
            20                  25                  30          


Arg Gly Val Gly Pro Arg Ala Cys Tyr Ser Ile Trp Leu Leu Leu Ala 
        35                  40                  45              


Pro Thr Pro Pro Leu Ser His Cys Leu Gln Ser Pro Gln Lys Gln His 
    50                  55                  60                  


Gln Val Cys Gly Asp Arg Arg Leu Lys Ala Ser Ser Thr Asn Cys Pro 
65                  70                  75                  80  


Ser Glu Lys Cys Thr Ala Trp Ala Arg Tyr Ser His Arg Met Asp Ser 
                85                  90                  95      


Leu Gln Lys Gln Asp Leu Arg Arg Pro Lys Ile His Gly Ala Val Gln 
            100                 105                 110         


Ala Ser Pro Tyr Gln Pro Pro Thr Leu Ala Ser Leu Gln Arg Leu Leu 
        115                 120                 125             


Trp Val Arg Gln Ala Ala Thr Leu Asn His Ile Asp Glu Val Trp Pro 
    130                 135                 140                 


Ser Leu Phe Leu Gly Asp Ala Tyr Ala Ala Arg Asp Lys Ser Lys Leu 
145                 150                 155                 160 


Ile Gln Leu Gly Ile Thr His Val Val Asn Ala Ala Ala Gly Lys Phe 
                165                 170                 175     


Gln Val Asp Thr Gly Ala Lys Phe Tyr Arg Gly Met Ser Leu Glu Tyr 
            180                 185                 190         


Tyr Gly Ile Glu Ala Asp Asp Asn Pro Phe Phe Asp Leu Ser Val Tyr 
        195                 200                 205             


Phe Leu Pro Val Ala Arg Tyr Ile Arg Ala Ala Leu Ser Val Pro Gln 
    210                 215                 220                 


Gly Arg Val Leu Val His Cys Ala Met Gly Val Ser Arg Ser Ala Thr 
225                 230                 235                 240 


Leu Val Leu Ala Phe Leu Met Ile Cys Glu Asn Met Thr Leu Val Glu 
                245                 250                 255     


Ala Ile Gln Thr Val Gln Ala His Arg Asn Ile Cys Pro Asn Ser Gly 
            260                 265                 270         


Phe Leu Arg Gln Leu Gln Val Leu Asp Asn Arg Leu Gly Arg Glu Thr 
        275                 280                 285             


Gly Arg Phe 
    290     


<210>  516
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  516

Met Ala Asp Ser Val Lys Thr Phe Leu Gln Asp Leu Ala Arg Gly Ile 
1               5                   10                  15      


Lys Asp Ser Ile Trp Gly Ile Cys Thr Ile Ser Lys Leu Asp Ala Arg 
            20                  25                  30          


Ile Gln Gln Lys Arg Glu Glu Gln Arg Arg Arg Arg Ala Ser Ser Val 
        35                  40                  45              


Leu Ala Gln Arg Arg Ala Gln Ser Ile Glu Arg Lys Gln Glu Ser Glu 
    50                  55                  60                  


Pro Arg Ile Val Ser Arg Ile Phe Gln Cys Cys Ala Trp Asn Gly Gly 
65                  70                  75                  80  


Val Phe Trp Phe Ser Leu Leu Leu Phe Tyr Arg Val Phe Ile Pro Val 
                85                  90                  95      


Leu Gln Ser Val Thr Ala Arg Ile Ile Gly Asp Pro Ser Leu His Gly 
            100                 105                 110         


Asp Val Trp Ser Trp Leu Glu Phe Phe Leu Thr Ser Ile Phe Ser Ala 
        115                 120                 125             


Leu Trp Val Leu Pro Leu Phe Val Leu Ser Lys Val Val Asn Ala Ile 
    130                 135                 140                 


Trp Phe Gln Asp Ile Ala Asp Leu Ala Phe Glu Val Ser Gly Arg Lys 
145                 150                 155                 160 


Pro His Pro Phe Pro Ser Val Ser Lys Ile Ile Ala Asp Met Leu Phe 
                165                 170                 175     


Asn Leu Leu Leu Gln Ala Leu Phe Leu Ile Gln Gly Met Phe Val Ser 
            180                 185                 190         


Leu Phe Pro Ile His Leu Val Gly Gln Leu Val Ser Leu Leu His Met 
        195                 200                 205             


Ser Leu Leu Tyr Ser Leu Tyr Cys Phe Glu Tyr Arg Trp Phe Asn Lys 
    210                 215                 220                 


Val Ala Ala Phe Ser Leu Ser Ser Phe Leu Tyr Ser Leu Ser Ala Pro 
225                 230                 235                 240 


Met Lys Gln Arg Pro Leu Ala Lys His Ile Ser Ser Ser Cys Ala Ser 
                245                 250                 255     


Ser Pro Trp Trp Ser Ser 
            260         


<210>  517
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  517

Met Asp Val Met Glu Leu Leu Glu Glu Asp Leu Thr Cys Pro Ile Cys 
1               5                   10                  15      


Cys Ser Leu Phe Asp Asp Pro Arg Val Leu Pro Cys Ser His Asn Phe 
            20                  25                  30          


Cys Lys Lys Cys Leu Glu Gly Ile Leu Glu Gly Ser Val Arg Asn Ser 
        35                  40                  45              


Leu Trp Arg Pro Ala Pro Phe Lys Cys Pro Thr Cys Arg Lys Glu Thr 
    50                  55                  60                  


Ser Ala Thr Gly Ile Asn Ser Leu Gln Val Asn Tyr Ser Leu Lys Gly 
65                  70                  75                  80  


Ile Val Glu Lys Tyr Asn Lys Ile Lys Ile Ser Pro Lys Met Pro Val 
                85                  90                  95      


Cys Lys Gly His Leu Gly Gln Pro Leu Asn Ile Phe Cys Leu Thr Asp 
            100                 105                 110         


Met Gln Leu Ile Cys Gly Ile Cys Ala Thr Arg Gly Glu His Thr Lys 
        115                 120                 125             


His Val Phe Cys Ser Ile Glu Asp Ala Tyr Ala Gln Glu Arg Asp Ala 
    130                 135                 140                 


Phe Glu Ser Leu Phe Gln Ser Phe Glu Thr Trp Arg Arg Gly Asp Ala 
145                 150                 155                 160 


Leu Ser Arg Leu Asp Thr Leu Glu Thr Ser Lys Arg Lys Ser Leu Gln 
                165                 170                 175     


Leu Leu Thr Lys Asp Ser Asp Lys Val Lys Glu Phe Phe Glu Lys Leu 
            180                 185                 190         


Gln His Thr Leu Asp Gln Lys Lys Asn Glu Ile Leu Ser Asp Phe Glu 
        195                 200                 205             


Thr Met Lys Leu Ala Val Met Gln Ala Tyr Asp Pro Glu Ile Asn Lys 
    210                 215                 220                 


Leu Asn Thr Ile Leu Gln Glu Gln Arg Met Ala Phe Asn Ile Ala Glu 
225                 230                 235                 240 


Ala Phe Lys Asp Val Ser Glu Pro Ile Val Phe Leu Gln Gln Met Gln 
                245                 250                 255     


Glu Phe Arg Glu Lys Ile Lys Val Ile Lys Glu Thr Pro Leu Pro Pro 
            260                 265                 270         


Ser Asn Leu Pro Ala Ser Pro Leu Met Lys Asn Phe Asp Thr Ser Gln 
        275                 280                 285             


Trp Glu Asp Ile Lys Leu Val Asp Val Asp Lys Leu Ser Leu Pro Gln 
    290                 295                 300                 


Asp Thr Gly Thr Phe Ile Ser Lys Ile Pro Trp Ser Phe Tyr Lys Leu 
305                 310                 315                 320 


Phe Leu Leu Ile Leu Leu Leu Gly Leu Val Ile Val Phe Gly Pro Thr 
                325                 330                 335     


Met Phe Leu Glu Trp Ser Leu Phe Asp Asp Leu Ala Thr Trp Lys Gly 
            340                 345                 350         


Cys Leu Ser Asn Phe Ser Ser Tyr Leu Thr Lys Thr Ala Asp Phe Ile 
        355                 360                 365             


Glu Gln Ser Val Phe Tyr Trp Glu Gln Val Thr Asp Gly Phe Phe Ile 
    370                 375                 380                 


Phe Asn Glu Arg Phe Lys Asn Phe Thr Leu Val Val Leu Asn Asn Val 
385                 390                 395                 400 


Ala Glu Phe Val Cys Lys Tyr Lys Leu Leu 
                405                 410 


<210>  518
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  518

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr 
            20                  25                  30          


Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
        35                  40                  45              


Leu Leu Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu Ile 
    50                  55                  60                  


Val Gly Ala Val Phe Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln 
65                  70                  75                  80  


Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly 
                85                  90          


<210>  519
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  519

Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His 
1               5                   10                  15      


Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser 
            20                  25                  30          


Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln 
        35                  40                  45              


Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp 
    50                  55                  60                  


Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp 
65                  70                  75                  80  


Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile 
                85                  90                  95      


Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly 
            100                 105                 110         


Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys 
        115                 120                 125             


Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn 
    130                 135                 140                 


Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu 
145                 150                 155                 160 


Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Cys Leu Pro Phe 
                165                 170                 175     


Phe Ser Leu Asp Ser Arg Leu Phe Tyr Ser Phe Trp Gly Ser Cys Gln 
            180                 185                 190         


Leu Asp Ser Val Gly Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile 
        195                 200                 205             


Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg 
    210                 215                 220                 


Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala 
225                 230                 235                 240 


Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly 
                245                 250                 255 


<210>  520
<211>  1707
<212>  PRT
<213>  Homo sapiens

<400>  520

Met Pro Glu Pro Trp Gly Thr Val Tyr Phe Leu Gly Ile Ala Gln Val 
1               5                   10                  15      


Phe Ser Phe Leu Phe Ser Trp Trp Asn Leu Glu Gly Val Met Asn Gln 
            20                  25                  30          


Ala Asp Ala Pro Arg Pro Leu Asn Trp Thr Ile Arg Lys Leu Cys His 
        35                  40                  45              


Ala Ala Phe Leu Pro Ser Val Arg Leu Leu Lys Ala Gln Lys Ser Trp 
    50                  55                  60                  


Ile Glu Arg Ala Phe Tyr Lys Arg Glu Cys Val His Ile Ile Pro Ser 
65                  70                  75                  80  


Thr Lys Asp Pro His Arg Cys Cys Cys Gly Arg Leu Ile Gly Gln His 
                85                  90                  95      


Val Gly Leu Thr Pro Ser Ile Ser Val Leu Gln Asn Glu Lys Asn Glu 
            100                 105                 110         


Ser Arg Leu Ser Arg Asn Asp Ile Gln Ser Glu Lys Trp Ser Ile Ser 
        115                 120                 125             


Lys His Thr Gln Leu Ser Pro Thr Asp Ala Phe Gly Thr Ile Glu Phe 
    130                 135                 140                 


Gln Gly Gly Gly His Ser Asn Lys Ala Met Tyr Val Arg Val Ser Phe 
145                 150                 155                 160 


Asp Thr Lys Pro Asp Leu Leu Leu His Leu Met Thr Lys Glu Trp Gln 
                165                 170                 175     


Leu Glu Leu Pro Lys Leu Leu Ile Ser Val His Gly Gly Leu Gln Asn 
            180                 185                 190         


Phe Glu Leu Gln Pro Lys Leu Lys Gln Val Phe Gly Lys Gly Leu Ile 
        195                 200                 205             


Lys Ala Ala Met Thr Thr Gly Ala Trp Ile Phe Thr Gly Gly Val Asn 
    210                 215                 220                 


Thr Gly Val Ile Arg His Val Gly Asp Ala Leu Lys Asp His Ala Ser 
225                 230                 235                 240 


Lys Ser Arg Gly Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly Ile 
                245                 250                 255     


Val Glu Asn Gln Glu Asp Leu Ile Gly Arg Asp Val Val Arg Pro Tyr 
            260                 265                 270         


Gln Thr Met Ser Asn Pro Met Ser Lys Leu Thr Val Leu Asn Ser Met 
        275                 280                 285             


His Ser His Phe Ile Leu Ala Asp Asn Gly Thr Thr Gly Lys Tyr Gly 
    290                 295                 300                 


Ala Glu Val Lys Leu Arg Arg Gln Leu Glu Lys His Ile Ser Leu Gln 
305                 310                 315                 320 


Lys Ile Asn Thr Arg Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile 
                325                 330                 335     


Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg 
            340                 345                 350         


Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala 
        355                 360                 365             


Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu 
    370                 375                 380                 


Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr 
385                 390                 395                 400 


Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met 
                405                 410                 415     


Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser 
            420                 425                 430         


Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys 
        435                 440                 445             


Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp 
    450                 455                 460                 


Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln 
465                 470                 475                 480 


Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu 
                485                 490                 495     


Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met 
            500                 505                 510         


His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg 
        515                 520                 525             


His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys 
    530                 535                 540                 


Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu 
545                 550                 555                 560 


Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg 
                565                 570                 575     


Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Pro 
            580                 585                 590         


Lys Ala Leu Lys Leu Leu Gly Met Glu Asp Asp Ile Pro Leu Arg Arg 
        595                 600                 605             


Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu 
    610                 615                 620                 


Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met 
625                 630                 635                 640 


Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp 
                645                 650                 655     


Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu 
            660                 665                 670         


Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp 
        675                 680                 685             


Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala 
    690                 695                 700                 


Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met 
705                 710                 715                 720 


Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu 
                725                 730                 735     


Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys 
            740                 745                 750         


Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg 
        755                 760                 765             


Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser 
    770                 775                 780                 


Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser 
785                 790                 795                 800 


Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu 
                805                 810                 815     


Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met 
            820                 825                 830         


Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu 
        835                 840                 845             


Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu 
    850                 855                 860                 


Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr 
865                 870                 875                 880 


Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu 
                885                 890                 895     


Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr 
            900                 905                 910         


Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys 
        915                 920                 925             


Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr 
    930                 935                 940                 


Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu 
945                 950                 955                 960 


Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn 
                965                 970                 975     


Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys 
            980                 985                 990         


Tyr Leu Gly Pro Tyr Val Met Met  Ile Gly Lys Met Met  Ile Asp Met 
        995                 1000                 1005             


Met Tyr  Phe Val Ile Ile Met  Leu Val Val Leu Met  Ser Phe Gly 
    1010                 1015                 1020             


Val Ala  Arg Gln Ala Ile Leu  Phe Pro Asn Glu Glu  Pro Ser Trp 
    1025                 1030                 1035             


Lys Leu  Ala Lys Asn Ile Phe  Tyr Met Pro Tyr Trp  Met Ile Tyr 
    1040                 1045                 1050             


Gly Glu  Val Phe Ala Asp Gln  Ile Asp Pro Pro Cys  Gly Gln Asn 
    1055                 1060                 1065             


Glu Thr  Arg Glu Asp Gly Lys  Ile Ile Gln Leu Pro  Pro Cys Lys 
    1070                 1075                 1080             


Thr Gly  Ala Trp Ile Val Pro  Ala Ile Met Ala Cys  Tyr Leu Leu 
    1085                 1090                 1095             


Val Ala  Asn Ile Leu Leu Val  Asn Leu Leu Ile Ala  Val Phe Asn 
    1100                 1105                 1110             


Asn Thr  Phe Phe Glu Val Lys  Ser Ile Ser Asn Gln  Val Trp Lys 
    1115                 1120                 1125             


Phe Gln  Arg Tyr Gln Leu Ile  Met Thr Phe His Glu  Arg Pro Val 
    1130                 1135                 1140             


Leu Pro  Pro Pro Leu Ile Ile  Phe Ser His Met Thr  Met Ile Phe 
    1145                 1150                 1155             


Gln His  Leu Cys Cys Arg Trp  Arg Lys His Glu Ser  Asp Pro Asp 
    1160                 1165                 1170             


Glu Arg  Asp Tyr Gly Leu Lys  Leu Phe Ile Thr Asp  Asp Glu Leu 
    1175                 1180                 1185             


Lys Lys  Val His Asp Phe Glu  Glu Gln Cys Ile Glu  Glu Tyr Phe 
    1190                 1195                 1200             


Arg Glu  Lys Asp Asp Arg Phe  Asn Ser Ser Asn Asp  Glu Arg Ile 
    1205                 1210                 1215             


Arg Val  Thr Ser Glu Arg Val  Glu Asn Met Ser Met  Arg Leu Glu 
    1220                 1225                 1230             


Glu Val  Asn Glu Arg Glu His  Ser Met Lys Ala Ser  Leu Gln Thr 
    1235                 1240                 1245             


Val Asp  Ile Arg Leu Ala Gln  Leu Glu Asp Leu Ile  Gly Arg Met 
    1250                 1255                 1260             


Ala Thr  Ala Leu Glu Arg Leu  Thr Gly Leu Glu Arg  Ala Glu Ser 
    1265                 1270                 1275             


Asn Lys  Ile Arg Ser Arg Thr  Ser Ser Asp Cys Thr  Asp Ala Ala 
    1280                 1285                 1290             


Tyr Ile  Val Arg Gln Ser Ser  Phe Asn Ser Gln Glu  Gly Asn Thr 
    1295                 1300                 1305             


Phe Lys  Leu Gln Glu Ser Ile  Asp Pro Ala Gly Glu  Glu Thr Met 
    1310                 1315                 1320             


Ser Pro  Thr Ser Pro Thr Leu  Met Pro Arg Met Arg  Ser His Ser 
    1325                 1330                 1335             


Phe Tyr  Ser Val Asn Met Lys  Asp Lys Gly Gly Ile  Glu Lys Leu 
    1340                 1345                 1350             


Glu Ser  Ile Phe Lys Glu Arg  Ser Leu Ser Leu His  Arg Ala Thr 
    1355                 1360                 1365             


Ser Ser  His Ser Val Ala Lys  Glu Pro Lys Ala Pro  Ala Ala Pro 
    1370                 1375                 1380             


Ala Asn  Thr Leu Ala Ile Val  Pro Asp Ser Arg Arg  Pro Ser Ser 
    1385                 1390                 1395             


Cys Ile  Asp Ile Tyr Val Ser  Ala Met Asp Glu Leu  His Cys Asp 
    1400                 1405                 1410             


Ile Asp  Pro Leu Asp Asn Ser  Val Asn Ile Leu Gly  Leu Gly Glu 
    1415                 1420                 1425             


Pro Ser  Phe Ser Thr Pro Val  Pro Ser Thr Ala Pro  Ser Ser Ser 
    1430                 1435                 1440             


Ala Tyr  Ala Thr Leu Ala Pro  Thr Asp Arg Pro Pro  Ser Arg Ser 
    1445                 1450                 1455             


Ile Asp  Phe Glu Asp Ile Thr  Ser Met Asp Thr Arg  Ser Phe Ser 
    1460                 1465                 1470             


Ser Asp  Tyr Thr His Leu Pro  Glu Cys Gln Asn Pro  Trp Asp Ser 
    1475                 1480                 1485             


Glu Pro  Pro Met Tyr His Thr  Ile Glu Arg Ser Lys  Ser Ser Arg 
    1490                 1495                 1500             


Tyr Leu  Ala Thr Thr Pro Phe  Leu Leu Glu Glu Ala  Pro Ile Val 
    1505                 1510                 1515             


Lys Ser  His Ser Phe Met Phe  Ser Pro Ser Arg Ser  Tyr Tyr Ala 
    1520                 1525                 1530             


Asn Phe  Gly Val Pro Val Lys  Thr Ala Glu Tyr Thr  Ser Ile Thr 
    1535                 1540                 1545             


Asp Cys  Ile Asp Thr Arg Cys  Val Asn Ala Pro Gln  Ala Ile Ala 
    1550                 1555                 1560             


Asp Arg  Ala Ala Phe Pro Gly  Gly Leu Gly Asp Lys  Val Glu Asp 
    1565                 1570                 1575             


Leu Thr  Cys Cys His Pro Glu  Arg Glu Ala Glu Leu  Ser His Pro 
    1580                 1585                 1590             


Ser Ser  Asp Ser Glu Glu Asn  Glu Ala Lys Gly Arg  Arg Ala Thr 
    1595                 1600                 1605             


Ile Ala  Ile Ser Ser Gln Glu  Gly Asp Asn Ser Glu  Arg Thr Leu 
    1610                 1615                 1620             


Ser Asn  Asn Ile Thr Val Pro  Lys Ile Glu Arg Ala  Asn Ser Tyr 
    1625                 1630                 1635             


Ser Ala  Glu Glu Pro Ser Ala  Pro Tyr Ala His Thr  Arg Lys Ser 
    1640                 1645                 1650             


Phe Ser  Ile Ser Asp Lys Leu  Asp Arg Gln Arg Asn  Thr Ala Ser 
    1655                 1660                 1665             


Leu Arg  Asn Pro Phe Gln Arg  Ser Lys Ser Ser Lys  Pro Glu Gly 
    1670                 1675                 1680             


Arg Gly  Asp Ser Leu Ser Met  Arg Arg Leu Ser Arg  Thr Ser Ala 
    1685                 1690                 1695             


Phe Gln  Ser Phe Glu Ser Lys  His Asn 
    1700                 1705         


<210>  521
<211>  695
<212>  PRT
<213>  Homo sapiens

<400>  521

Met Ser Gly Ala Ala Leu Gly Leu Glu Ile Val Phe Val Phe Phe Leu 
1               5                   10                  15      


Ala Leu Phe Leu Leu His Arg Tyr Gly Asp Phe Lys Lys Gln His Arg 
            20                  25                  30          


Leu Val Ile Ile Gly Thr Leu Leu Ala Trp Tyr Leu Cys Phe Leu Ile 
        35                  40                  45              


Val Phe Ile Leu Pro Leu Asp Val Ser Thr Thr Ile Tyr Asn Arg Cys 
    50                  55                  60                  


Lys His Ala Ala Ala Asn Ser Ser Pro Pro Glu Asn Ser Asn Ile Thr 
65                  70                  75                  80  


Gly Leu Tyr Ala Thr Ala Asn Pro Val Pro Ser Gln His Pro Cys Phe 
                85                  90                  95      


Lys Pro Trp Ser Tyr Ile Pro Asp Gly Ile Met Pro Ile Phe Trp Arg 
            100                 105                 110         


Val Val Tyr Trp Thr Ser Gln Phe Leu Thr Trp Ile Leu Leu Pro Phe 
        115                 120                 125             


Met Gln Ser Tyr Ala Arg Ser Gly Gly Phe Ser Ile Thr Gly Lys Ile 
    130                 135                 140                 


Lys Thr Ala Leu Ile Glu Asn Ala Ile Tyr Tyr Gly Thr Tyr Leu Leu 
145                 150                 155                 160 


Ile Phe Gly Ala Phe Leu Ile Tyr Val Ala Val Asn Pro His Leu His 
                165                 170                 175     


Leu Glu Trp Asn Gln Leu Gln Thr Ile Gly Ile Ala Ala Ala Asn Thr 
            180                 185                 190         


Trp Gly Leu Phe Leu Leu Val Leu Leu Leu Gly Tyr Gly Leu Val Glu 
        195                 200                 205             


Ile Pro Arg Ser Tyr Trp Asn Gly Ala Lys Arg Gly Tyr Leu Leu Met 
    210                 215                 220                 


Lys Thr Tyr Phe Lys Ala Ala Lys Leu Met Thr Glu Lys Ala Asp Ala 
225                 230                 235                 240 


Glu Glu Asn Leu Glu Asp Ala Met Glu Glu Val Arg Lys Val Asn Glu 
                245                 250                 255     


Ser Ile Lys Tyr Asn His Pro Leu Arg Lys Cys Val Asp Thr Ile Leu 
            260                 265                 270         


Lys Lys Cys Pro Thr Glu Tyr Gln Glu Lys Met Gly Arg Asn Met Asp 
        275                 280                 285             


Asp Tyr Glu Asp Phe Asp Glu Lys His Ser Ile Tyr Pro Ser Glu Lys 
    290                 295                 300                 


Ser Leu Val Lys Leu His Lys Gln Val Ile Tyr Ser Val Gln Arg His 
305                 310                 315                 320 


Arg Arg Thr Gln Val Gln Trp Gln Ile Leu Leu Glu Gln Ala Phe Tyr 
                325                 330                 335     


Leu Glu Asp Val Ala Lys Asn Glu Thr Ser Ala Thr His Gln Phe Val 
            340                 345                 350         


His Thr Phe Gln Ser Pro Glu Pro Glu Asn Arg Phe Ile Gln Tyr Phe 
        355                 360                 365             


Tyr Asn Pro Thr Phe Glu Trp Tyr Trp Glu Cys Leu Leu Arg Pro Trp 
    370                 375                 380                 


Phe Tyr Lys Ile Leu Ala Val Val Leu Ser Ile Phe Ser Val Ile Val 
385                 390                 395                 400 


Val Trp Ser Glu Cys Thr Phe Phe Ser Thr Thr Pro Val Leu Ser Leu 
                405                 410                 415     


Phe Ala Val Phe Ile Gln Leu Ala Glu Lys Thr Tyr Asn Tyr Ile Tyr 
            420                 425                 430         


Ile Glu Ile Ala Cys Phe Leu Ser Ile Phe Phe Leu Ser Ile Cys Val 
        435                 440                 445             


Tyr Ser Thr Val Phe Arg Ile Arg Val Phe Asn Tyr Tyr Tyr Leu Ala 
    450                 455                 460                 


Ser His His Gln Thr Asp Ala Tyr Ser Leu Leu Phe Ser Gly Met Leu 
465                 470                 475                 480 


Phe Cys Arg Leu Thr Pro Pro Leu Cys Leu Asn Phe Leu Gly Leu Thr 
                485                 490                 495     


His Met Asp Ser Ser Ile Ser His Lys Asn Thr Gln Pro Thr Ala Tyr 
            500                 505                 510         


Thr Ser Ile Met Gly Ser Met Lys Val Leu Ser Phe Ile Ala Asp Gly 
        515                 520                 525             


Phe Tyr Ile Tyr Tyr Pro Met Leu Val Val Ile Leu Cys Ile Ala Thr 
    530                 535                 540                 


Tyr Phe Ser Leu Gly Thr Arg Cys Leu Asn Leu Leu Gly Phe Gln Gln 
545                 550                 555                 560 


Phe Met Gly Asp Asp Asp Met Thr Ser Asp Leu Val Asn Glu Gly Lys 
                565                 570                 575     


Glu Leu Ile Arg Lys Glu Lys Arg Lys Arg Gln Arg Gln Glu Glu Gly 
            580                 585                 590         


Glu Asn Arg Arg Arg Glu Trp Lys Glu Arg Tyr Gly His Asn Arg Glu 
        595                 600                 605             


Asp Ser Thr Arg Asn Arg Asn Ile His Thr Asp Pro Lys Glu Ser Asn 
    610                 615                 620                 


Phe Ser Asp Val Asn Thr Asn Arg Ser Ala Phe Lys Tyr Thr Arg Ala 
625                 630                 635                 640 


Asn Asn Arg Thr Glu Arg Asp Arg Ile Glu Leu Leu Gln Asp Ala Glu 
                645                 650                 655     


Pro Leu Asp Phe Asn Ala Glu Thr Phe Thr Asp Asp Pro Leu Glu Ser 
            660                 665                 670         


Glu Ser Gly Arg Tyr Gln Pro Gly Gly Arg Tyr Leu Ser Met Ser Arg 
        675                 680                 685             


Ser Asp Ile Phe Asn Asp Val 
    690                 695 


<210>  522
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  522

Met Trp Gly Ala Arg Arg Ser Ser Val Ser Ser Ser Trp Asn Ala Ala 
1               5                   10                  15      


Ser Leu Leu Gln Leu Leu Leu Ala Ala Leu Leu Ala Ala Gly Ala Arg 
            20                  25                  30          


Ala Ser Gly Glu Tyr Cys His Gly Trp Leu Asp Ala Gln Gly Val Trp 
        35                  40                  45              


Arg Ile Gly Phe Gln Cys Pro Glu Arg Phe Asp Gly Gly Asp Ala Thr 
    50                  55                  60                  


Ile Cys Cys Gly Ser Cys Ala Leu Arg Tyr Cys Cys Ser Ser Ala Glu 
65                  70                  75                  80  


Ala Arg Leu Asp Gln Gly Gly Cys Asp Asn Asp Arg Gln Gln Gly Ala 
                85                  90                  95      


Gly Glu Pro Gly Arg Ala Asp Lys Asp Gly Pro Asp Gly Ser Ala Val 
            100                 105                 110         


Pro Ile Tyr Val Pro Phe Leu Ile Val Gly Ser Val Phe Val Ala Phe 
        115                 120                 125             


Ile Ile Leu Gly Ser Leu Val Ala Ala Cys Cys Cys Arg Cys Leu Arg 
    130                 135                 140                 


Pro Lys Gln Asp Pro Gln Gln Ser Arg Ala Pro Gly Gly Asn Arg Leu 
145                 150                 155                 160 


Met Glu Thr Ile Pro Met Ile Pro Ser Ala Ser Thr Ser Arg Gly Ser 
                165                 170                 175     


Ser Ser Arg Gln Ser Ser Thr Ala Ala Ser Ser Ser Ser Ser Ala Asn 
            180                 185                 190         


Ser Gly Ala Arg Ala Pro Pro Thr Arg Ser Gln Thr Asn Cys Cys Leu 
        195                 200                 205             


Pro Glu Gly Thr Met Asn Asn Val Tyr Val Asn Met Pro Thr Asn Phe 
    210                 215                 220                 


Ser Val Leu Asn Cys Gln Gln Ala Thr Gln Ile Val Pro His Gln Gly 
225                 230                 235                 240 


Gln Tyr Leu His Pro Pro Tyr Val Gly Tyr Thr Val Gln His Asp Ser 
                245                 250                 255     


Val Pro Met Thr Ala Val Pro Pro Phe Met Asp Gly Leu Gln Pro Gly 
            260                 265                 270         


Tyr Arg Gln Ile Gln Ser Pro Phe Pro His Thr Asn Ser Glu Gln Lys 
        275                 280                 285             


Met Tyr Pro Ala Val Thr Val 
    290                 295 


<210>  523
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  523

Met Leu Thr Glu Val Met Glu Val Trp His Gly Leu Val Ile Ala Val 
1               5                   10                  15      


Val Ser Leu Phe Leu Gln Ala Cys Phe Leu Thr Ala Ile Asn Tyr Leu 
            20                  25                  30          


Leu Ser Arg His Met Ala His Lys Ser Glu Gln Ile Leu Lys Ala Ala 
        35                  40                  45              


Ser Leu Gln Val Pro Arg Pro Ser Pro Gly His His His Pro Pro Ala 
    50                  55                  60                  


Val Lys Glu Met Lys Glu Thr Gln Thr Glu Arg Asp Ile Pro Met Ser 
65                  70                  75                  80  


Asp Ser Leu Tyr Arg His Asp Ser Asp Thr Pro Ser Asp Ser Leu Asp 
                85                  90                  95      


Ser Ser Cys Ser Ser Pro Pro Ala Cys Gln Ala Thr Glu Asp Val Asp 
            100                 105                 110         


Tyr Thr Gln Val Val Phe Ser Asp Pro Gly Glu Leu Lys Asn Asp Ser 
        115                 120                 125             


Pro Leu Asp Tyr Glu Asn Ile Lys Glu Ile Thr Asp Tyr Val Asn Val 
    130                 135                 140                 


Asn Pro Glu Arg His Lys Pro Ser Phe Trp Tyr Phe Val Asn Pro Ala 
145                 150                 155                 160 


Leu Ser Glu Pro Ala Glu Tyr Asp Gln Val Ala Met 
                165                 170         


<210>  524
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  524

Met Pro Arg Tyr Gly Ala Ser Leu Arg Gln Ser Cys Pro Arg Ser Gly 
1               5                   10                  15      


Arg Glu Gln Gly Gln Asp Gly Thr Ala Gly Ala Pro Gly Leu Leu Trp 
            20                  25                  30          


Met Gly Leu Val Leu Ala Leu Ala Leu Ala Leu Ala Leu Ala Leu Ala 
        35                  40                  45              


Leu Ser Asp Ser Arg Val Leu Trp Ala Pro Ala Glu Ala His Pro Leu 
    50                  55                  60                  


Ser Pro Gln Gly His Pro Ala Arg Leu His Arg Ile Val Pro Arg Leu 
65                  70                  75                  80  


Arg Asp Val Phe Gly Trp Gly Asn Leu Thr Cys Pro Ile Cys Lys Gly 
                85                  90                  95      


Leu Phe Thr Ala Ile Asn Leu Gly Leu Lys Glu Pro Asn Val Ala Arg 
            100                 105                 110         


Val Gly Ser Val Ala Ile Lys Leu Cys Asn Leu Leu Lys Ile Ala Pro 
        115                 120                 125             


Pro Ala Val Cys Gln Ser Ile Val His Leu Phe Glu Asp Asp Met Val 
    130                 135                 140                 


Glu Val Trp Arg Arg Ser Val Leu Ser Pro Ser Glu Ala Cys Gly Leu 
145                 150                 155                 160 


Leu Leu Gly Ser Thr Cys Gly His Trp Asp Ile Phe Ser Ser Trp Asn 
                165                 170                 175     


Ile Ser Leu Pro Thr Val Pro Lys Pro Pro Pro Lys Pro Pro Ser Pro 
            180                 185                 190         


Pro Ala Pro Gly Ala Pro Val Ser Arg Ile Leu Phe Leu Thr Asp Leu 
        195                 200                 205             


His Trp Asp His Asp Tyr Leu Glu Gly Thr Asp Pro Asp Cys Ala Asp 
    210                 215                 220                 


Pro Leu Cys Cys Arg Arg Gly Ser Gly Leu Pro Pro Ala Ser Arg Pro 
225                 230                 235                 240 


Gly Ala Gly Tyr Trp Gly Glu Tyr Ser Lys Cys Asp Leu Pro Leu Arg 
                245                 250                 255     


Thr Leu Glu Ser Leu Leu Ser Gly Leu Gly Pro Ala Gly Pro Phe Asp 
            260                 265                 270         


Met Val Tyr Trp Thr Gly Asp Ile Pro Ala His Asp Val Trp His Gln 
        275                 280                 285             


Thr Arg Gln Asp Gln Leu Arg Ala Leu Thr Thr Val Thr Ala Leu Val 
    290                 295                 300                 


Arg Lys Phe Leu Gly Pro Val Pro Val Tyr Pro Ala Val Gly Asn His 
305                 310                 315                 320 


Glu Ser Thr Pro Val Asn Ser Phe Pro Pro Pro Phe Ile Glu Gly Asn 
                325                 330                 335     


His Ser Ser Arg Trp Leu Tyr Glu Ala Met Ala Lys Ala Trp Glu Pro 
            340                 345                 350         


Trp Leu Pro Ala Glu Ala Leu Arg Thr Leu Arg Ile Gly Gly Phe Tyr 
        355                 360                 365             


Ala Leu Ser Pro Tyr Pro Gly Leu Arg Leu Ile Ser Leu Asn Met Asn 
    370                 375                 380                 


Phe Cys Ser Arg Glu Asn Phe Trp Leu Leu Ile Asn Ser Thr Asp Pro 
385                 390                 395                 400 


Ala Gly Gln Leu Gln Trp Leu Val Gly Glu Leu Gln Ala Ala Glu Asp 
                405                 410                 415     


Arg Gly Asp Lys Val His Ile Ile Gly His Ile Pro Pro Gly His Cys 
            420                 425                 430         


Leu Lys Ser Trp Ser Trp Asn Tyr Tyr Arg Ile Val Ala Arg Tyr Glu 
        435                 440                 445             


Asn Thr Leu Ala Ala Gln Phe Phe Gly His Thr His Val Asp Glu Phe 
    450                 455                 460                 


Glu Val Phe Tyr Asp Glu Glu Thr Leu Ser Arg Pro Leu Ala Val Ala 
465                 470                 475                 480 


Phe Leu Ala Pro Ser Ala Thr Thr Tyr Ile Gly Leu Asn Pro Gly Tyr 
                485                 490                 495     


Arg Val Tyr Gln Ile Asp Gly Asn Tyr Ser Gly Ser Ser His Val Val 
            500                 505                 510         


Leu Asp His Glu Thr Tyr Ile Leu Asn Leu Thr Gln Ala Asn Ile Pro 
        515                 520                 525             


Gly Ala Ile Pro His Trp Gln Leu Leu Tyr Arg Ala Arg Glu Thr Tyr 
    530                 535                 540                 


Gly Leu Pro Asn Thr Leu Pro Thr Ala Trp His Asn Leu Val Tyr Arg 
545                 550                 555                 560 


Met Arg Gly Asp Met Gln Leu Phe Gln Thr Phe Trp Phe Leu Tyr His 
                565                 570                 575     


Lys Gly His Pro Pro Ser Glu Pro Cys Gly Thr Pro Cys Arg Leu Ala 
            580                 585                 590         


Thr Leu Cys Ala Gln Leu Ser Ala Arg Ala Asp Ser Pro Ala Leu Cys 
        595                 600                 605             


Arg His Leu Met Pro Asp Gly Ser Leu Pro Glu Ala Gln Ser Leu Trp 
    610                 615                 620                 


Pro Arg Pro Leu Phe Cys 
625                 630 


<210>  525
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  525

Met Lys Glu Ala Ala Leu Ile Cys Leu Ala Pro Ser Val Pro Pro Ile 
1               5                   10                  15      


Leu Thr Val Lys Ser Trp Asp Thr Met Gln Leu Arg Ala Ala Arg Ser 
            20                  25                  30          


Arg Cys Thr Asn Leu Leu Ala Ala Ser Tyr Ile Glu Asn Gln Gln His 
        35                  40                  45              


Leu Gln His Leu Glu Leu Arg Asp Leu Arg Gly Leu Gly Glu Leu Arg 
    50                  55                  60                  


Asn Leu Thr Ile Val Lys Ser Gly Leu Arg Phe Val Ala Pro Asp Ala 
65                  70                  75                  80  


Phe His Phe Thr Pro Arg Leu Ser Arg Leu Asn Leu Ser Phe Asn Ala 
                85                  90                  95      


Leu Glu Ser Leu Ser Trp Lys Thr Val Gln Gly Leu Ser Leu Gln Glu 
            100                 105                 110         


Leu Val Leu Ser Gly Asn Pro Leu His Cys Ser Cys Ala Leu Arg Trp 
        115                 120                 125             


Leu Gln Arg Trp Glu Glu Glu Gly Leu Gly Gly Val Pro Glu Gln Lys 
    130                 135                 140                 


Leu Gln Cys His Gly Gln Gly Pro Leu Ala His Met Pro Asn Ala Ser 
145                 150                 155                 160 


Cys Gly Val Pro Thr Leu Lys Val Gln Val Pro Asn Ala Ser Val Asp 
                165                 170                 175     


Val Gly Asp Asp Val Leu Leu Arg Cys Gln Val Glu Gly Arg Gly Leu 
            180                 185                 190         


Glu Gln Ala Gly Trp Ile Leu Thr Glu Leu Glu Gln Ser Ala Thr Val 
        195                 200                 205             


Met Lys Ser Gly Gly Leu Pro Ser Leu Gly Leu Thr Leu Ala Asn Val 
    210                 215                 220                 


Thr Ser Asp Leu Asn Arg Lys Asn Val Thr Cys Trp Ala Glu Asn Asp 
225                 230                 235                 240 


Val Gly Arg Ala Glu Val Ser Val Gln Val Asn Val Ser Phe Pro Ala 
                245                 250                 255     


Ser Val Gln Leu His Thr Ala Val Glu Met His His Trp Cys Ile Pro 
            260                 265                 270         


Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn 
        275                 280                 285             


Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu 
    290                 295                 300                 


Pro Ala Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln 
305                 310                 315                 320 


Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro 
                325                 330                 335     


Phe Gly Gln Ala Ser Ala Ser Ile Met Ala Ala Phe Met Asp Asn Pro 
            340                 345                 350         


Phe Glu Phe Asn Pro Glu Asp Pro Ile Pro Asp Thr Asn Ser Thr Ser 
        355                 360                 365             


Gly Asp Pro Val Glu Lys Lys Asp Glu Thr Pro Phe Gly Val Ser Val 
    370                 375                 380                 


Ala Val Gly Leu Ala Val Phe Ala Cys Leu Phe Leu Ser Thr Leu Leu 
385                 390                 395                 400 


Leu Val Leu Asn Lys Cys Gly Arg Arg Asn Lys Phe Gly Ile Asn Arg 
                405                 410                 415     


Pro Ala Val Leu Ala Pro Glu Asp Gly Leu Ala Met Ser Leu His Phe 
            420                 425                 430         


Met Thr Leu Gly Gly Ser Ser Leu Ser Pro Thr Glu Gly Lys Gly Ser 
        435                 440                 445             


Gly Leu Gln Gly His Ile Ile Glu Asn Pro Gln Tyr Phe Ser Asp Ala 
    450                 455                 460                 


Cys Val His His Ile Lys Arg Arg Asp Ile Val Leu Lys Trp Glu Leu 
465                 470                 475                 480 


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys His Asn Leu 
                485                 490                 495     


Leu Pro Glu Gln Asp Lys Met Leu Val Ala Val Lys Ala Leu Lys Glu 
            500                 505                 510         


Ala Ser Glu Ser Ala Arg Gln Asp Phe Gln Arg Glu Ala Glu Leu Leu 
        515                 520                 525             


Thr Met Leu Gln His Gln His Ile Val Arg Phe Phe Gly Val Cys Thr 
    530                 535                 540                 


Glu Gly Arg Pro Leu Leu Met Val Phe Glu Tyr Met Arg His Gly Asp 
545                 550                 555                 560 


Leu Asn Arg Phe Leu Arg Ser His Gly Pro Asp Ala Lys Leu Leu Ala 
                565                 570                 575     


Gly Gly Glu Asp Val Ala Pro Gly Pro Leu Gly Leu Gly Gln Leu Leu 
            580                 585                 590         


Ala Val Ala Ser Gln Val Ala Ala Gly Met Val Tyr Leu Ala Gly Leu 
        595                 600                 605             


His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Gln 
    610                 615                 620                 


Gly Leu Val Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Ile Tyr 
625                 630                 635                 640 


Ser Thr Asp Tyr Tyr Arg Val Gly Gly Arg Thr Met Leu Pro Ile Arg 
                645                 650                 655     


Trp Met Pro Pro Glu Ser Ile Leu Tyr Arg Lys Phe Thr Thr Glu Ser 
            660                 665                 670         


Asp Val Trp Ser Phe Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly 
        675                 680                 685             


Lys Gln Pro Trp Tyr Gln Leu Ser Asn Thr Glu Ala Ile Asp Cys Ile 
    690                 695                 700                 


Thr Gln Gly Arg Glu Leu Glu Arg Pro Arg Ala Cys Pro Pro Glu Val 
705                 710                 715                 720 


Tyr Ala Ile Met Arg Gly Cys Trp Gln Arg Glu Pro Gln Gln Arg His 
                725                 730                 735     


Ser Ile Lys Asp Val His Ala Arg Leu Gln Ala Leu Ala Gln Ala Pro 
            740                 745                 750         


Pro Val Tyr Leu Asp Val Leu Gly 
        755                 760 


<210>  526
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  526

Met Ser Gly His Arg Ser Thr Arg Lys Arg Cys Gly Asp Ser His Pro 
1               5                   10                  15      


Glu Ser Pro Val Gly Phe Gly His Met Ser Thr Thr Gly Cys Val Leu 
            20                  25                  30          


Asn Lys Leu Phe Gln Leu Pro Thr Pro Pro Leu Ser Arg His Gln Leu 
        35                  40                  45              


Lys Arg Leu Glu Glu His Arg Tyr Gln Ser Ala Gly Arg Ser Leu Leu 
    50                  55                  60                  


Glu Pro Leu Met Gln Gly Tyr Trp Glu Trp Leu Val Arg Arg Val Pro 
65                  70                  75                  80  


Ser Trp Ile Ala Pro Asn Leu Ile Thr Ile Ile Gly Leu Ser Ile Asn 
                85                  90                  95      


Ile Cys Thr Thr Ile Leu Leu Val Phe Tyr Cys Pro Thr Ala Thr Glu 
            100                 105                 110         


Gln Ala Pro Leu Trp Ala Tyr Ile Ala Cys Ala Cys Gly Leu Phe Ile 
        115                 120                 125             


Tyr Gln Ser Leu Asp Ala Ile Asp Gly Lys Gln Ala Arg Arg Thr Asn 
    130                 135                 140                 


Ser Ser Ser Pro Leu Gly Glu Leu Phe Asp His Gly Cys Asp Ser Leu 
145                 150                 155                 160 


Ser Thr Val Phe Val Val Leu Gly Thr Cys Ile Ala Val Gln Leu Gly 
                165                 170                 175     


Thr Asn Pro Asp Trp Met Phe Phe Cys Cys Phe Ala Gly Thr Phe Met 
            180                 185                 190         


Phe Tyr Cys Ala His Trp Gln Thr Tyr Val Ser Gly Thr Leu Arg Phe 
        195                 200                 205             


Gly Ile Ile Asp Val Thr Glu Val Gln Ile Phe Ile Ile Ile Met His 
    210                 215                 220                 


Leu Leu Ala Val Ile Gly Gly Pro Pro Phe Trp Gln Ser Met Ile Pro 
225                 230                 235                 240 


Val Leu Asn Ile Gln Met Lys Ile Phe Pro Ala Leu Cys Thr Val Ala 
                245                 250                 255     


Gly Thr Ile Phe Ser Cys Thr Asn Tyr Phe Arg Val Ile Phe Thr Gly 
            260                 265                 270         


Gly Val Gly Lys Asn Gly Ser Thr Ile Ala Gly Thr Ser Val Leu Ser 
        275                 280                 285             


Pro Phe Leu His Ile Gly Ser Val Ile Thr Leu Ala Ala Met Ile Tyr 
    290                 295                 300                 


Lys Lys Ser Ala Val Gln Leu Phe Glu Lys His Pro Cys Leu Tyr Ile 
305                 310                 315                 320 


Leu Thr Phe Gly Phe Val Ser Ala Lys Ile Thr Asn Lys Leu Val Val 
                325                 330                 335     


Ala His Met Thr Lys Ser Glu Met His Leu His Asp Thr Ala Phe Ile 
            340                 345                 350         


Gly Pro Ala Leu Leu Phe Leu Asp Gln Tyr Phe Asn Ser Phe Ile Asp 
        355                 360                 365             


Glu Tyr Ile Val Leu Trp Ile Ala Leu Val Phe Ser Phe Phe Asp Leu 
    370                 375                 380                 


Ile Arg Tyr Cys Val Ser Val Cys Asn Gln Ile Ala Ser His Leu His 
385                 390                 395                 400 


Ile His Val Phe Arg Ile Lys Val Ser Thr Ala His Ser Asn His His 
                405                 410                 415     


<210>  527
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  527

Met Ser Val Met Val Val Arg Lys Lys Val Thr Arg Lys Trp Glu Lys 
1               5                   10                  15      


Leu Pro Gly Arg Asn Thr Phe Cys Cys Asp Gly Arg Val Met Met Ala 
            20                  25                  30          


Arg Gln Lys Gly Ile Phe Tyr Leu Thr Leu Phe Leu Ile Leu Gly Thr 
        35                  40                  45              


Cys Thr Leu Phe Phe Ala Phe Glu Cys Arg Tyr Leu Ala Val Gln Leu 
    50                  55                  60                  


Ser Pro Ala Ile Pro Val Phe Ala Ala Met Leu Phe Leu Phe Ser Met 
65                  70                  75                  80  


Ala Thr Leu Leu Arg Thr Ser Phe Ser Asp Pro Gly Val Ile Pro Arg 
                85                  90                  95      


Ala Leu Pro Asp Glu Ala Ala Phe Ile Glu Met Glu Ile Glu Ala Thr 
            100                 105                 110         


Asn Gly Ala Val Pro Gln Gly Gln Arg Pro Pro Pro Arg Ile Lys Asn 
        115                 120                 125             


Phe Gln Ile Asn Asn Gln Ile Val Lys Leu Lys Tyr Cys Tyr Thr Cys 
    130                 135                 140                 


Lys Ile Phe Arg Pro Pro Arg Ala Ser His Cys Ser Ile Cys Asp Asn 
145                 150                 155                 160 


Cys Val Glu Arg Phe Asp His His Cys Pro Trp Val Gly Asn Cys Val 
                165                 170                 175     


Gly Lys Arg Asn Tyr Arg Tyr Phe Tyr Leu Phe Ile Leu Ser Leu Ser 
            180                 185                 190         


Leu Leu Thr Ile Tyr Val Phe Ala Phe Asn Ile Val Tyr Val Ala Leu 
        195                 200                 205             


Lys Ser Leu Lys Ile Gly Phe Leu Glu Thr Leu Lys Glu Thr Pro Gly 
    210                 215                 220                 


Thr Val Leu Glu Val Leu Ile Cys Phe Phe Thr Leu Trp Ser Val Val 
225                 230                 235                 240 


Gly Leu Thr Gly Phe His Thr Phe Leu Val Ala Leu Asn Gln Thr Thr 
                245                 250                 255     


Asn Glu Asp Ile Lys Gly Ser Trp Thr Gly Lys Asn Arg Val Gln Asn 
            260                 265                 270         


Pro Tyr Ser His Gly Asn Ile Val Lys Asn Cys Cys Glu Val Leu Cys 
        275                 280                 285             


Gly Pro Leu Pro Pro Ser Val Leu Asp Arg Arg Gly Ile Leu Pro Leu 
    290                 295                 300                 


Glu Glu Ser Gly Ser Arg Pro Pro Ser Thr Gln Glu Thr Ser Ser Ser 
305                 310                 315                 320 


Leu Leu Pro Gln Ser Pro Ala Pro Thr Glu His Leu Asn Ser Asn Glu 
                325                 330                 335     


Met Pro Glu Asp Ser Ser Thr Pro Glu Glu Met Pro Pro Pro Glu Pro 
            340                 345                 350         


Pro Glu Pro Pro Gln Glu Ala Ala Glu Ala Glu Lys 
        355                 360                 


<210>  528
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  528

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Glu Ser Phe Gly Val Leu Gly Pro Gln Val Lys 
        195                 200                 205             


Glu Pro Lys Lys Thr Gly Gln Phe Leu Glu Glu Leu Arg Asn Pro Phe 
    210                 215                 220                 


<210>  529
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  529

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Val Phe His Leu Glu Ala Leu Ser Gly 
        195                 200                 205     


<210>  530
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  530

Met Val Leu Glu Ser Val Ala Arg Ile Val Lys Val Gln Leu Pro Ala 
1               5                   10                  15      


Tyr Leu Lys Arg Leu Pro Val Pro Glu Ser Ile Thr Gly Phe Ala Arg 
            20                  25                  30          


Leu Thr Val Ser Glu Trp Leu Arg Leu Leu Pro Phe Leu Gly Val Leu 
        35                  40                  45              


Ala Leu Leu Gly Tyr Leu Ala Val Arg Pro Phe Leu Pro Lys Lys Lys 
    50                  55                  60                  


Gln Gln Lys Asp Ser Leu Ile Asn Leu Lys Ile Gln Lys Glu Asn Pro 
65                  70                  75                  80  


Lys Val Val Asn Glu Ile Asn Ile Glu Asp Leu Cys Leu Thr Lys Ala 
                85                  90                  95      


Ala Tyr Cys Arg Cys Trp Arg Ser Lys Thr Phe Pro Ala Cys Asp Gly 
            100                 105                 110         


Ser His Asn Lys His Asn Glu Leu Thr Gly Asp Asn Val Gly Pro Leu 
        115                 120                 125             


Ile Leu Lys Lys Lys Glu Val 
    130                 135 


<210>  531
<211>  640
<212>  PRT
<213>  Homo sapiens

<400>  531

Met Gly Gln Pro Ser Leu Thr Trp Met Leu Met Val Val Val Ala Ser 
1               5                   10                  15      


Trp Phe Ile Thr Thr Ala Ala Thr Asp Thr Ser Glu Ala Arg Trp Cys 
            20                  25                  30          


Ser Glu Cys His Ser Asn Ala Thr Cys Thr Glu Asp Glu Ala Val Thr 
        35                  40                  45              


Thr Cys Thr Cys Gln Glu Gly Phe Thr Gly Asp Gly Leu Thr Cys Val 
    50                  55                  60                  


Asp Leu Asp Glu Cys Ala Ile Pro Gly Ala His Asn Cys Ser Ala Asn 
65                  70                  75                  80  


Ser Ser Cys Val Asn Thr Pro Gly Ser Phe Ser Cys Val Cys Pro Glu 
                85                  90                  95      


Gly Phe Arg Leu Ser Pro Gly Leu Gly Cys Thr Asp Val Asp Glu Cys 
            100                 105                 110         


Ala Glu Pro Gly Leu Ser His Cys His Ala Leu Ala Thr Cys Val Asn 
        115                 120                 125             


Val Val Gly Ser Tyr Leu Cys Val Cys Pro Ala Gly Tyr Arg Gly Asp 
    130                 135                 140                 


Gly Trp His Cys Glu Cys Ser Pro Gly Ser Cys Gly Pro Gly Leu Asp 
145                 150                 155                 160 


Cys Val Pro Glu Gly Asp Ala Leu Val Cys Ala Asp Pro Cys Gln Ala 
                165                 170                 175     


His Arg Thr Leu Asp Glu Tyr Trp Arg Ser Thr Glu Tyr Gly Glu Gly 
            180                 185                 190         


Tyr Ala Cys Asp Thr Asp Leu Arg Gly Trp Tyr Arg Phe Val Gly Gln 
        195                 200                 205             


Gly Gly Ala Arg Met Ala Glu Thr Cys Val Pro Val Leu Arg Cys Asn 
    210                 215                 220                 


Thr Ala Ala Pro Met Trp Leu Asn Gly Thr His Pro Ser Ser Asp Glu 
225                 230                 235                 240 


Gly Ile Val Ser Arg Lys Ala Cys Ala His Trp Ser Gly His Cys Cys 
                245                 250                 255     


Leu Trp Asp Ala Ser Val Gln Val Lys Ala Cys Ala Gly Gly Tyr Tyr 
            260                 265                 270         


Val Tyr Asn Leu Thr Ala Pro Pro Glu Cys His Leu Ala Tyr Cys Thr 
        275                 280                 285             


Asp Pro Ser Ser Val Glu Gly Thr Cys Glu Glu Cys Ser Ile Asp Glu 
    290                 295                 300                 


Asp Cys Lys Ser Asn Asn Gly Arg Trp His Cys Gln Cys Lys Gln Asp 
305                 310                 315                 320 


Phe Asn Ile Thr Asp Ile Ser Leu Leu Glu His Arg Leu Glu Cys Gly 
                325                 330                 335     


Ala Asn Asp Met Lys Val Ser Leu Gly Lys Cys Gln Leu Lys Ser Leu 
            340                 345                 350         


Gly Phe Asp Lys Val Phe Met Tyr Leu Ser Asp Ser Arg Cys Ser Gly 
        355                 360                 365             


Phe Asn Asp Arg Asp Asn Arg Asp Trp Val Ser Val Val Thr Pro Ala 
    370                 375                 380                 


Arg Asp Gly Pro Cys Gly Thr Val Leu Thr Arg Asn Glu Thr His Ala 
385                 390                 395                 400 


Thr Tyr Ser Asn Thr Leu Tyr Leu Ala Asp Glu Ile Ile Ile Arg Asp 
                405                 410                 415     


Leu Asn Ile Lys Ile Asn Phe Ala Cys Ser Tyr Pro Leu Asp Met Lys 
            420                 425                 430         


Val Ser Leu Lys Thr Ala Leu Gln Pro Met Val Ser Ala Leu Asn Ile 
        435                 440                 445             


Arg Val Gly Gly Thr Gly Met Phe Thr Val Arg Met Ala Leu Phe Gln 
    450                 455                 460                 


Thr Pro Ser Tyr Thr Gln Pro Tyr Gln Gly Ser Ser Val Thr Leu Ser 
465                 470                 475                 480 


Thr Glu Ala Phe Leu Tyr Val Gly Thr Met Leu Asp Gly Gly Asp Leu 
                485                 490                 495     


Ser Arg Phe Ala Leu Leu Met Thr Asn Cys Tyr Ala Thr Pro Ser Ser 
            500                 505                 510         


Asn Ala Thr Asp Pro Leu Lys Tyr Phe Ile Ile Gln Asp Arg Cys Pro 
        515                 520                 525             


His Thr Arg Asp Ser Thr Ile Gln Val Val Glu Asn Gly Glu Ser Ser 
    530                 535                 540                 


Gln Gly Arg Phe Ser Val Gln Met Phe Arg Phe Ala Gly Asn Tyr Asp 
545                 550                 555                 560 


Leu Val Tyr Leu His Cys Glu Val Tyr Leu Cys Asp Thr Met Asn Glu 
                565                 570                 575     


Lys Cys Lys Pro Thr Cys Ser Gly Thr Arg Phe Arg Ser Gly Ser Val 
            580                 585                 590         


Ile Asp Gln Ser Arg Val Leu Asn Leu Gly Pro Ile Thr Arg Lys Gly 
        595                 600                 605             


Val Gln Ala Thr Val Ser Arg Ala Phe Ser Ser Leu Gly Leu Leu Lys 
    610                 615                 620                 


Val Trp Leu Pro Leu Leu Leu Ser Ala Thr Leu Thr Leu Thr Phe Gln 
625                 630                 635                 640 


<210>  532
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  532

Met Glu Pro Leu Ala Ala Tyr Pro Leu Lys Cys Ser Gly Pro Arg Ala 
1               5                   10                  15      


Lys Val Phe Ala Val Leu Leu Ser Ile Val Leu Cys Thr Val Thr Leu 
            20                  25                  30          


Phe Leu Leu Gln Leu Lys Phe Leu Lys Pro Lys Ile Asn Ser Phe Tyr 
        35                  40                  45              


Ala Phe Glu Val Lys Asp Ala Lys Gly Arg Thr Val Ser Leu Glu Lys 
    50                  55                  60                  


Tyr Lys Gly Lys Val Ser Leu Val Val Asn Val Ala Ser Asp Cys Gln 
65                  70                  75                  80  


Leu Thr Asp Arg Asn Tyr Leu Gly Leu Lys Glu Leu His Lys Glu Phe 
                85                  90                  95      


Gly Pro Ser His Phe Ser Val Leu Ala Phe Pro Cys Asn Gln Phe Gly 
            100                 105                 110         


Glu Ser Glu Pro Arg Pro Ser Lys Glu Val Glu Ser Phe Ala Arg Lys 
        115                 120                 125             


Asn Tyr Gly Val Thr Phe Pro Ile Phe His Lys Ile Lys Ile Leu Gly 
    130                 135                 140                 


Ser Glu Gly Glu Pro Ala Phe Arg Phe Leu Val Asp Ser Ser Lys Lys 
145                 150                 155                 160 


Glu Pro Arg Trp Asn Phe Trp Lys Tyr Leu Val Asn Pro Glu Gly Gln 
                165                 170                 175     


Val Val Lys Phe Trp Lys Pro Glu Glu Pro Ile Glu Val Ile Arg Pro 
            180                 185                 190         


Asp Ile Ala Ala Leu Val Arg Gln Val Ile Ile Lys Lys Lys Glu Asp 
        195                 200                 205             


Leu 
    


<210>  533
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  533

Met Arg Thr Ala Ala Gly Ala Val Ser Pro Asp Ser Arg Pro Glu Thr 
1               5                   10                  15      


Arg Arg Gln Thr Arg Lys Asn Glu Glu Ala Ala Trp Gly Pro Arg Val 
            20                  25                  30          


Cys Arg Ala Glu Arg Glu Asp Asn Arg Lys Cys Pro Pro Ser Ile Leu 
        35                  40                  45              


Lys Arg Ser Arg Pro Glu His His Arg Pro Glu Ala Lys Pro Gln Arg 
    50                  55                  60                  


Thr Ser Arg Arg Val Trp Phe Arg Glu Pro Pro Ala Val Thr Val His 
65                  70                  75                  80  


Tyr Ile Ala Asp Lys Asn Ala Thr Ala Thr Val Arg Val Pro Gly Arg 
                85                  90                  95      


Pro Arg Pro His Gly Gly Ser Leu Leu Leu Gln Leu Cys Val Cys Val 
            100                 105                 110         


Leu Leu Val Leu Ala Leu Gly Leu Tyr Cys Gly Arg Ala Lys Pro Val 
        115                 120                 125             


Ala Thr Ala Leu Glu Asp Leu Arg Ala Arg Leu Leu Gly Leu Val Leu 
    130                 135                 140                 


His Leu Arg His Val Ala Leu Thr Cys Trp Arg Gly Leu Leu Arg Leu 
145                 150                 155                 160 


<210>  534
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  534

Met Thr Leu Gln Trp Ala Ala Val Ala Thr Phe Leu Tyr Ala Glu Ile 
1               5                   10                  15      


Gly Leu Ile Leu Ile Phe Cys Leu Pro Phe Ile Pro Pro Gln Arg Trp 
            20                  25                  30          


Gln Lys Ile Phe Ser Phe Asn Val Trp Gly Lys Ile Ala Thr Phe Trp 
        35                  40                  45              


Asn Lys Ala Phe Leu Thr Ile Ile Ile Leu Leu Ile Val Leu Phe Leu 
    50                  55                  60                  


Asp Ala Val Arg Glu Val Arg Lys Tyr Ser Ser Val His Thr Ile Glu 
65                  70                  75                  80  


Lys Ser Ser Thr Ser Arg Pro Asp Ala Tyr Glu His Thr Gln Met Lys 
                85                  90                  95      


Leu Phe Arg Ser Gln Arg Asn Leu Tyr Ile Ser Gly Phe Ser Leu Phe 
            100                 105                 110         


Phe Trp Leu Val Leu Arg Arg Leu Val Thr Leu Ile Thr Gln Leu Ala 
        115                 120                 125             


Lys Glu Leu Ser Asn Lys Gly Val Leu Lys Thr Gln Ala Glu Asn Thr 
    130                 135                 140                 


Asn Lys Ala Ala Lys Lys Phe Met Glu Glu Asn Glu Lys Leu Lys Arg 
145                 150                 155                 160 


Ile Leu Lys Ser His Gly Lys Asp Glu Glu Cys Val Leu Glu Ala Glu 
                165                 170                 175     


Asn Lys Lys Leu Val Glu Asp Gln Glu Lys Leu Lys Thr Glu Leu Arg 
            180                 185                 190         


Lys Thr Ser Asp Ala Leu Ser Lys Ala Gln Asn Asp Val Met Glu Met 
        195                 200                 205             


Lys Met Gln Ser Glu Arg Leu Ser Lys Glu Tyr Asp Gln Leu Leu Lys 
    210                 215                 220                 


Glu His Ser Glu Leu Gln His Ser Ser Phe Gly Glu Phe Leu Ser Lys 
225                 230                 235                 240 


Arg Ser His Lys Asn Gly Ser Ile Gly Lys Gln Thr Gly Ser Arg Lys 
                245                 250                 255     


Gly Ser Phe Arg Lys Arg Gln Gln Glu Lys Thr Val Asn Phe Ile Lys 
            260                 265                 270         


Asp Thr Cys Asn Ile Leu Cys Gln Asn Asp Asn Phe Val Met Leu Ala 
        275                 280                 285             


Ser Arg Lys Phe Lys Phe Arg Lys Met His Tyr Asp Arg Phe Val Ile 
    290                 295                 300                 


Phe Leu Met Pro His Ile Gly Cys Ile Val Met Ala Leu Ser Lys Tyr 
305                 310                 315                 320 


Leu Met Met Phe Gln Ile Tyr Cys Lys Val Cys Ile Pro Ala Leu Lys 
                325                 330                 335     


Lys Asn Ile Ser Met Leu Asn Thr Ile Phe Thr Tyr 
            340                 345             


<210>  535
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  535

Met Thr Leu Gln Trp Ala Ala Val Ala Thr Phe Leu Tyr Ala Glu Ile 
1               5                   10                  15      


Gly Leu Ile Leu Ile Phe Cys Leu Pro Phe Ile Pro Pro Gln Arg Trp 
            20                  25                  30          


Gln Lys Ile Phe Ser Phe Asn Val Trp Gly Lys Ile Ala Thr Phe Trp 
        35                  40                  45              


Asn Lys Ala Phe Leu Thr Ile Ile Ile Leu Leu Ile Val Leu Phe Leu 
    50                  55                  60                  


Asp Ala Val Arg Glu Val Arg Lys Tyr Ser Ser Val His Thr Ile Glu 
65                  70                  75                  80  


Lys Ser Ser Thr Ser Arg Pro Asp Ala Tyr Glu His Thr Gln Met Lys 
                85                  90                  95      


Leu Phe Arg Ser Gln Arg Asn Leu Tyr Ile Ser Gly Phe Ser Leu Phe 
            100                 105                 110         


Phe Trp Leu Val Leu Arg Arg Leu Val Thr Leu Ile Thr Gln Leu Ala 
        115                 120                 125             


Lys Glu Leu Ser Asn Lys Gly Val Leu Lys Thr Gln Ala Glu Asn Thr 
    130                 135                 140                 


Asn Lys Ala Ala Lys Lys Phe Met Glu Glu Asn Glu Lys Leu Lys Arg 
145                 150                 155                 160 


Ile Leu Lys Ser His Gly Lys Asp Glu Glu Cys Val Leu Glu Ala Glu 
                165                 170                 175     


Asn Lys Lys Leu Val Glu Asp Gln Glu Lys Leu Lys Thr Glu Leu Arg 
            180                 185                 190         


Lys Thr Ser Asp Ala Leu Ser Lys Ala Gln Asn Asp Val Met Glu Met 
        195                 200                 205             


Lys Met Gln Ser Glu Arg Leu Ser Lys Glu Tyr Asp Gln Leu Leu Lys 
    210                 215                 220                 


Glu His Ser Glu Leu Gln Lys Gln Arg Glu Ile Leu Pro His Arg Arg 
225                 230                 235                 240 


Gly Glu Ser Thr Val Thr Thr Glu Ala Glu Ile Gly Val Met Glu Pro 
                245                 250                 255     


Gln Gln Arg Asn Ala Asp Ser His Gln Lys Leu Glu Glu Ala Lys Asn 
            260                 265                 270         


Arg Phe Phe Pro Arg Ala Ser Ser Ser Arg Ser Met Ala Leu Gln Ile 
        275                 280                 285             


Pro Ile Lys Leu Ile Leu Asp Phe Leu Ala Ser Arg Thr Met Gly Ile 
    290                 295                 300                 


Asn Leu Leu Phe Gln Ala Ile Lys Phe Val Ile Ile Cys Tyr Cys Cys 
305                 310                 315                 320 


His Ser Lys Leu Ile Gln Glu His Ala Gly Gln Ile Cys Asn Gly Leu 
                325                 330                 335     


Asn 
    


<210>  536
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  536

Met Thr Leu Gln Trp Ala Ala Val Ala Thr Phe Leu Tyr Ala Glu Ile 
1               5                   10                  15      


Gly Leu Ile Leu Ile Phe Cys Leu Pro Phe Ile Pro Pro Gln Arg Trp 
            20                  25                  30          


Gln Lys Ile Phe Ser Phe Asn Val Trp Gly Lys Ile Ala Thr Phe Trp 
        35                  40                  45              


Asn Lys Ala Phe Leu Thr Ile Ile Ile Leu Leu Ile Val Leu Phe Leu 
    50                  55                  60                  


Asp Ala Val Arg Glu Val Arg Lys Tyr Ser Ser Val His Thr Ile Glu 
65                  70                  75                  80  


Lys Ser Ser Thr Ser Arg Pro Asp Ala Tyr Glu His Thr Gln Met Lys 
                85                  90                  95      


Leu Phe Arg Ser Gln Arg Asn Leu Tyr Ile Ser Gly Phe Ser Leu Phe 
            100                 105                 110         


Phe Trp Leu Val Leu Arg Arg Leu Val Thr Leu Ile Thr Gln Leu Ala 
        115                 120                 125             


Lys Glu Leu Ser Asn Lys Gly Val Leu Lys Thr Gln Ala Glu Asn Thr 
    130                 135                 140                 


Asn Lys Ala Ala Lys Lys Phe Met Glu Glu Asn Glu Lys Leu Lys Arg 
145                 150                 155                 160 


Ile Leu Lys Ser His Gly Lys Asp Glu Glu Cys Val Leu Glu Ala Glu 
                165                 170                 175     


Asn Lys Lys Leu Val Glu Asp Gln Glu Lys Leu Lys Thr Glu Leu Arg 
            180                 185                 190         


Lys Thr Ser Asp Ala Leu Ser Lys Ala Gln Asn Asp Val Met Glu Met 
        195                 200                 205             


Lys Met Gln Ser Glu Arg Leu Ser Lys Glu Tyr Asp Gln Leu Leu Lys 
    210                 215                 220                 


Glu His Ser Glu Leu Gln Val Phe Ala Lys Leu Leu Asn Tyr Leu Leu 
225                 230                 235                 240 


Met Arg Lys Trp 
                


<210>  537
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  537

Met Asp Gly Thr Glu Thr Arg Gln Arg Arg Leu Asp Ser Cys Gly Lys 
1               5                   10                  15      


Pro Gly Glu Leu Gly Leu Pro His Pro Leu Ser Thr Gly Gly Leu Pro 
            20                  25                  30          


Val Ala Ser Glu Asp Gly Ala Leu Arg Ala Pro Glu Ser Gln Ser Val 
        35                  40                  45              


Thr Pro Lys Pro Leu Glu Thr Glu Pro Ser Arg Glu Thr Ala Trp Ser 
    50                  55                  60                  


Ile Gly Leu Gln Val Thr Val Pro Phe Met Phe Ala Gly Leu Gly Leu 
65                  70                  75                  80  


Ser Trp Ala Gly Met Leu Leu Asp Tyr Phe Gln His Trp Pro Val Phe 
                85                  90                  95      


Val Glu Val Lys Asp Leu Leu Thr Leu Val Pro Pro Leu Val Gly Leu 
            100                 105                 110         


Lys Gly Asn Leu Glu Met Thr Leu Ala Ser Arg Leu Ser Thr Ala Ala 
        115                 120                 125             


Asn Thr Gly Gln Ile Asp Asp Pro Gln Glu Gln His Arg Val Ile Ser 
    130                 135                 140                 


Ser Asn Leu Ala Leu Ile Gln Val Gln Ala Thr Val Val Gly Leu Leu 
145                 150                 155                 160 


Ala Ala Val Ala Ala Leu Leu Leu Gly Val Val Ser Arg Glu Glu Val 
                165                 170                 175     


Asp Val Ala Lys Val Glu Leu Leu Cys Ala Ser Ser Val Leu Thr Ala 
            180                 185                 190         


Phe Leu Ala Ala Phe Ala Leu Gly Val Leu Met Val Cys Ile Val Ile 
        195                 200                 205             


Gly Ala Arg Lys Leu Gly Val Asn Pro Asp Asn Ile Ala Thr Pro Ile 
    210                 215                 220                 


Ala Ala Ser Leu Gly Asp Leu Ile Thr Leu Ser Ile Leu Ala Leu Val 
225                 230                 235                 240 


Ser Ser Phe Phe Tyr Arg His Lys Asp Ser Arg Tyr Leu Thr Pro Leu 
                245                 250                 255     


Val Cys Leu Ser Phe Ala Ala Leu Thr Pro Val Trp Val Leu Ile Ala 
            260                 265                 270         


Lys Gln Ser Pro Pro Ile Val Lys Ile Leu Lys Phe Gly Trp Phe Pro 
        275                 280                 285             


Ile Ile Leu Ala Met Val Ile Ser Ser Phe Gly Gly Leu Ile Leu Ser 
    290                 295                 300                 


Lys Thr Val Ser Lys Gln Gln Tyr Lys Gly Met Ala Ile Phe Thr Pro 
305                 310                 315                 320 


Val Ile Cys Gly Val Gly Gly Asn Leu Val Ala Ile Gln Thr Ser Arg 
                325                 330                 335     


Ile Ser Thr Tyr Leu His Met Trp Ser Ala Pro Gly Val Leu Pro Leu 
            340                 345                 350         


Gln Met Lys Lys Phe Trp Pro Asn Pro Cys Ser Thr Phe Cys Thr Ser 
        355                 360                 365             


Glu Ile Asn Ser Met Ser Ala Arg Val Leu Leu Leu Leu Val Val Pro 
    370                 375                 380                 


Gly His Leu Ile Phe Phe Tyr Ile Ile Tyr Leu Val Glu Gly Gln Ser 
385                 390                 395                 400 


Val Ile Asn Ser Gln Thr Phe Val Val Leu Tyr Leu Leu Ala Gly Leu 
                405                 410                 415     


Ile Gln Val Thr Ile Leu Leu Tyr Leu Ala Glu Val Met Val Arg Leu 
            420                 425                 430         


Thr Trp His Gln Ala Leu Asp Pro Asp Asn His Cys Ile Pro Tyr Leu 
        435                 440                 445             


Thr Gly Leu Gly Asp Leu Leu Gly Ser Ser Ser Val Gly His Thr Ala 
    450                 455                 460                 


Ala Val Pro Arg Arg Cys Thr Ala Ser Pro Gly Trp Gly Leu Ile Gln 
465                 470                 475                 480 


Pro Phe Ile Cys Thr Gln His Leu Ile Val Ser Leu Leu Ser Phe Tyr 
                485                 490                 495     


Phe Pro Phe Cys Leu Leu Ala Lys Thr Ser Ile 
            500                 505         


<210>  538
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  538

Met Asp Gly Thr Glu Thr Arg Gln Arg Arg Leu Asp Ser Cys Gly Lys 
1               5                   10                  15      


Pro Gly Glu Leu Gly Leu Pro His Pro Leu Ser Thr Gly Gly Leu Pro 
            20                  25                  30          


Val Ala Ser Glu Asp Gly Ala Leu Arg Ala Pro Glu Ser Gln Ser Val 
        35                  40                  45              


Thr Pro Lys Pro Leu Glu Thr Glu Pro Ser Arg Glu Thr Ala Trp Ser 
    50                  55                  60                  


Ile Gly Leu Gln Val Thr Val Pro Phe Met Phe Ala Gly Leu Gly Leu 
65                  70                  75                  80  


Ser Trp Ala Gly Met Leu Leu Asp Tyr Phe Gln Ala Asn Thr Gly Gln 
                85                  90                  95      


Ile Asp Asp Pro Gln Glu Gln His Arg Val Ile Ser Ser Asn Leu Ala 
            100                 105                 110         


Leu Ile Gln Val Gln Ala Thr Val Val Gly Leu Leu Ala Ala Val Ala 
        115                 120                 125             


Ala Leu Leu Leu Gly Val Val Ser Arg Glu Glu Val Asp Val Ala Lys 
    130                 135                 140                 


Val Glu Leu Leu Cys Ala Ser Ser Val Leu Thr Ala Phe Leu Ala Ala 
145                 150                 155                 160 


Phe Ala Leu Gly Val Leu Met Val Cys Ile Val Ile Gly Ala Arg Lys 
                165                 170                 175     


Leu Gly Val Asn Pro Asp Asn Ile Ala Thr Pro Ile Ala Ala Ser Leu 
            180                 185                 190         


Gly Asp Leu Ile Thr Leu Ser Ile Leu Ala Leu Val Ser Ser Phe Phe 
        195                 200                 205             


Tyr Arg His Lys Asp Ser Arg Tyr Leu Thr Pro Leu Val Cys Leu Ser 
    210                 215                 220                 


Phe Ala Ala Leu Thr Pro Val Trp Val Leu Ile Ala Lys Gln Ser Pro 
225                 230                 235                 240 


Pro Ile Val Lys Ile Leu Lys Phe Gly Trp Phe Pro Ile Ile Leu Ala 
                245                 250                 255     


Met Val Ile Ser Ser Phe Gly Gly Leu Ile Leu Ser Lys Thr Val Ser 
            260                 265                 270         


Lys Gln Gln Tyr Lys Gly Met Ala Ile Phe Thr Pro Val Ile Cys Gly 
        275                 280                 285             


Val Gly Gly Asn Leu Val Ala Ile Gln Thr Ser Arg Ile Ser Thr Tyr 
    290                 295                 300                 


Leu His Met Trp Ser Ala Pro Gly Val Leu Pro Leu Gln Met Lys Lys 
305                 310                 315                 320 


Phe Trp Pro Asn Pro Cys Ser Thr Phe Cys Thr Ser Glu Ile Asn Ser 
                325                 330                 335     


Met Ser Ala Arg Val Leu Leu Leu Leu Val Val Pro Gly His Leu Ile 
            340                 345                 350         


Phe Phe Tyr Ile Ile Tyr Leu Val Glu Gly Gln Ser Val Ile Asn Ser 
        355                 360                 365             


Gln Thr Phe Val Val Leu Tyr Leu Leu Ala Gly Leu Ile Gln Val Thr 
    370                 375                 380                 


Ile Leu Leu Tyr Leu Ala Glu Val Met Val Arg Leu Thr Trp His Gln 
385                 390                 395                 400 


Ala Leu Asp Pro Asp Asn His Cys Ile Pro Tyr Leu Thr Gly Leu Gly 
                405                 410                 415     


Asp Leu Leu Gly Ser Ser Ser Val Gly His Thr Ala Ala Val Pro Arg 
            420                 425                 430         


Arg Cys Thr Ala Ser Pro Gly Trp Gly Leu Ile Gln Pro Phe Ile Cys 
        435                 440                 445             


Thr Gln His Leu Ile Val Ser Leu Leu Ser Phe Tyr Phe Pro Phe Cys 
    450                 455                 460                 


Leu Leu Ala Lys Thr Ser Ile 
465                 470     


<210>  539
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  539

Met Val Val Thr Gln Leu Asn Leu Glu Phe Cys Phe Gln Gly Lys Lys 
1               5                   10                  15      


Leu Arg Gly Phe Ser Cys Glu Leu Thr Arg Ser Pro His Gly Val Leu 
            20                  25                  30          


Pro Glu Ser Phe Phe Thr Ile Met Cys Gln Val Val Val Pro Ile Leu 
        35                  40                  45              


Leu Ser Gly Leu Cys Met Met Thr Ala Gly Leu Val Met Asn Thr Ile 
    50                  55                  60                  


Gln His Trp Pro Val Phe Val Glu Val Lys Asp Leu Leu Thr Leu Val 
65                  70                  75                  80  


Pro Pro Leu Val Gly Leu Lys Gly Asn Leu Glu Met Thr Leu Ala Ser 
                85                  90                  95      


Arg Leu Ser Thr Ala Ala Asn Thr Gly Gln Ile Asp Asp Pro Gln Glu 
            100                 105                 110         


Gln His Arg Val Ile Ser Ser Asn Leu Ala Leu Ile Gln Val Gln Ala 
        115                 120                 125             


Thr Val Val Gly Leu Leu Ala Ala Val Ala Ala Leu Leu Leu Gly Val 
    130                 135                 140                 


Val Ser Arg Glu Glu Val Asp Val Ala Lys Val Glu Leu Leu Cys Ala 
145                 150                 155                 160 


Ser Ser Val Leu Thr Ala Phe Leu Ala Ala Phe Ala Leu Gly Val Leu 
                165                 170                 175     


Met Val Cys Ile Val Ile Gly Ala Arg Lys Leu Gly Val Asn Pro Asp 
            180                 185                 190         


Asn Ile Ala Thr Pro Ile Ala Ala Ser Leu Gly Asp Leu Ile Thr Leu 
        195                 200                 205             


Ser Ile Leu Ala Leu Val Ser Ser Phe Phe Tyr Arg His Lys Asp Ser 
    210                 215                 220                 


Arg Tyr Leu Thr Pro Leu Val Cys Leu Ser Phe Ala Ala Leu Thr Pro 
225                 230                 235                 240 


Val Trp Val Leu Ile Ala Lys Gln Ser Pro Pro Ile Val Lys Ile Leu 
                245                 250                 255     


Lys Phe Gly Trp Phe Pro Ile Ile Leu Ala Met Val Ile Ser Ser Phe 
            260                 265                 270         


Gly Gly Leu Ile Leu Ser Lys Thr Val Ser Lys Gln Gln Tyr Lys Gly 
        275                 280                 285             


Met Ala Ile Phe Thr Pro Val Ile Cys Gly Val Gly Gly Asn Leu Val 
    290                 295                 300                 


Ala Ile Gln Thr Ser Arg Ile Ser Thr Tyr Leu His Met Trp Ser Ala 
305                 310                 315                 320 


Pro Gly Val Leu Pro Leu Gln Met Lys Lys Phe Trp Pro Asn Pro Cys 
                325                 330                 335     


Ser Thr Phe Cys Thr Ser Glu Ile Asn Ser Met Ser Ala Arg Val Leu 
            340                 345                 350         


Leu Leu Leu Val Val Pro Gly His Leu Ile Phe Phe Tyr Ile Ile Tyr 
        355                 360                 365             


Leu Val Glu Gly Gln Ser Val Ile Asn Ser Gln Thr Phe Val Val Leu 
    370                 375                 380                 


Tyr Leu Leu Ala Gly Leu Ile Gln Val Thr Ile Leu Leu Tyr Leu Ala 
385                 390                 395                 400 


Glu Val Met Val Arg Leu Thr Trp His Gln Ala Leu Asp Pro Asp Asn 
                405                 410                 415     


His Cys Ile Pro Tyr Leu Thr Gly Leu Gly Asp Leu Leu Gly Thr Gly 
            420                 425                 430         


Leu Leu Ala Leu Cys Phe Phe Thr Asp Trp Leu Leu Lys Ser Lys Ala 
        435                 440                 445             


Glu Leu Gly Gly Ile Ser Glu Leu Ala Ser Gly Pro Pro 
    450                 455                 460     


<210>  540
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  540

Met Arg Ser Pro Gly Gly Ile Leu Leu Gln Ala Leu Pro Arg Leu Leu 
1               5                   10                  15      


Gln His Ala Ala Leu Pro Gly Leu Ala Glu Leu Pro Ala Arg Trp Ala 
            20                  25                  30          


Leu Pro Arg Gly Ala Gly Gly Asp Gly Pro Ala Asp Arg Leu Pro Arg 
        35                  40                  45              


Gly Gly Gly Ala Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Ala 
    50                  55                  60                  


Leu Leu Gly Ala Tyr Leu Glu Arg His Gly Pro Pro Glu Ala Ser Glu 
65                  70                  75                  80  


Leu Pro Glu Pro Gly Gly Ala Leu Ala Gly Gly Pro Gly Ser Gly Gly 
                85                  90                  95      


Gly Gly Val Val Val Gly Val Ala Glu Val Arg Asn Trp Arg Cys Cys 
            100                 105                 110         


Cys Leu Gly Ser Thr Cys Trp Cys Arg Ser Leu Val Leu Val Cys Val 
        115                 120                 125             


Leu Ala Ala Leu Cys Phe Ala Ser Leu Ala Leu Val Arg Arg Tyr Leu 
    130                 135                 140                 


His His Leu Leu Leu Trp Val Glu Ser Leu Asp Ser Leu Leu Gly Val 
145                 150                 155                 160 


Leu Leu Phe Val Val Gly Phe Ile Val Val Ser Phe Pro Cys Gly Trp 
                165                 170                 175     


Gly Tyr Ile Val Leu Asn Val Ala Ala Gly Tyr Leu Tyr Gly Phe Val 
            180                 185                 190         


Leu Gly Met Gly Leu Met Met Val Gly Val Leu Ile Gly Thr Phe Ile 
        195                 200                 205             


Ala His Val Val Cys Lys Arg Leu Leu Thr Ala Trp Val Ala Ala Arg 
    210                 215                 220                 


Ile Gln Ser Ser Glu Lys Leu Ser Ala Val Ile Arg Val Val Glu Gly 
225                 230                 235                 240 


Gly Ser Gly Leu Lys Val Val Ala Leu Ala Arg Leu Thr Pro Ile Pro 
                245                 250                 255     


Phe Gly Leu Gln Asn Ala Val Phe Ser Ile Thr Asp Leu Ser Leu Pro 
            260                 265                 270         


Asn Tyr Leu Met Ala Ser Ser Val Gly Leu Leu Pro Thr Gln Leu Leu 
        275                 280                 285             


Asn Ser Tyr Leu Gly Thr Thr Leu Arg Thr Met Glu Asp Val Ile Ala 
    290                 295                 300                 


Glu Gln Ser Val Ser Gly Tyr Phe Val Phe Cys Leu Gln Ile Ile Ile 
305                 310                 315                 320 


Ser Ile Gly Leu Met Phe Tyr Val Val His Arg Ala Gln Val Glu Leu 
                325                 330                 335     


Asn Ala Ala Ile Val Ala Cys Glu Met Glu Leu Lys Ser Ser Leu Val 
            340                 345                 350         


Lys Gly Asn Gln Pro Asn Thr Ser Gly Ser Ser Phe Tyr Asn Lys Arg 
        355                 360                 365             


Thr Leu Thr Phe Ser Gly Gly Gly Ile Asn Val Val 
    370                 375                 380 


<210>  541
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  541

Met Asp Ser Ser Ala Ala Pro Thr Asn Ala Ser Asn Cys Thr Asp Ala 
1               5                   10                  15      


Leu Ala Tyr Ser Ser Cys Ser Pro Ala Pro Ser Pro Gly Ser Trp Val 
            20                  25                  30          


Asn Leu Ser His Leu Asp Gly Asn Leu Ser Asp Pro Cys Gly Pro Asn 
        35                  40                  45              


Arg Thr Asp Leu Gly Gly Arg Asp Ser Leu Cys Pro Pro Thr Gly Ser 
    50                  55                  60                  


Pro Ser Met Ile Thr Ala Ile Thr Ile Met Ala Leu Tyr Ser Ile Val 
65                  70                  75                  80  


Cys Val Val Gly Leu Phe Gly Asn Phe Leu Val Met Tyr Val Ile Val 
                85                  90                  95      


Arg Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile Tyr Ile Phe Asn Leu 
            100                 105                 110         


Ala Leu Ala Asp Ala Leu Ala Thr Ser Thr Leu Pro Phe Gln Ser Val 
        115                 120                 125             


Asn Tyr Leu Met Gly Thr Trp Pro Phe Gly Thr Ile Leu Cys Lys Ile 
    130                 135                 140                 


Val Ile Ser Ile Asp Tyr Tyr Asn Met Phe Thr Ser Ile Phe Thr Leu 
145                 150                 155                 160 


Cys Thr Met Ser Val Asp Arg Tyr Ile Ala Val Cys His Pro Val Lys 
                165                 170                 175     


Ala Leu Asp Phe Arg Thr Pro Arg Asn Ala Lys Ile Ile Asn Val Cys 
            180                 185                 190         


Asn Trp Ile Leu Ser Ser Ala Ile Gly Leu Pro Val Met Phe Met Ala 
        195                 200                 205             


Thr Thr Lys Tyr Arg Gln Gly Ser Ile Asp Cys Thr Leu Thr Phe Ser 
    210                 215                 220                 


His Pro Thr Trp Tyr Trp Glu Asn Leu Leu Lys Ile Cys Val Phe Ile 
225                 230                 235                 240 


Phe Ala Phe Ile Met Pro Val Leu Ile Ile Thr Val Cys Tyr Gly Leu 
                245                 250                 255     


Met Ile Leu Arg Leu Lys Ser Val Arg Met Leu Ser Gly Ser Lys Glu 
            260                 265                 270         


Lys Asp Arg Asn Leu Arg Arg Ile Thr Arg Met Val Leu Val Val Val 
        275                 280                 285             


Ala Val Phe Ile Val Cys Trp Thr Pro Ile His Ile Tyr Val Ile Ile 
    290                 295                 300                 


Lys Ala Leu Val Thr Ile Pro Glu Thr Thr Phe Gln Thr Val Ser Trp 
305                 310                 315                 320 


His Phe Cys Ile Ala Leu Gly Tyr Thr Asn Ser Cys Leu Asn Pro Val 
                325                 330                 335     


Leu Tyr Ala Phe Leu Asp Glu Asn Phe Lys Arg Cys Phe Arg Glu Phe 
            340                 345                 350         


Cys Ile Pro Thr Ser Ser Asn Ile Glu Gln Gln Asn Ser Thr Arg Ile 
        355                 360                 365             


Arg Gln Asn Thr Arg Asp His Pro Ser Thr Ala Asn Thr Val Asp Arg 
    370                 375                 380                 


Thr Asn His Gln Pro Pro Leu Ala Val Ser Met Ala Gln Ile Phe Thr 
385                 390                 395                 400 


Arg Tyr Pro Pro Pro Thr His Arg Glu Lys Thr Cys Asn Asp Tyr Met 
                405                 410                 415     


Lys Arg 
        


<210>  542
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  542

Met Asp Ser Ser Ala Ala Pro Thr Asn Ala Ser Asn Cys Thr Asp Ala 
1               5                   10                  15      


Leu Ala Tyr Ser Ser Cys Ser Pro Ala Pro Ser Pro Gly Ser Trp Val 
            20                  25                  30          


Asn Leu Ser His Leu Asp Gly Asn Leu Ser Asp Pro Cys Gly Pro Asn 
        35                  40                  45              


Arg Thr Asp Leu Gly Gly Arg Asp Ser Leu Cys Pro Pro Thr Gly Ser 
    50                  55                  60                  


Pro Ser Met Ile Thr Ala Ile Thr Ile Met Ala Leu Tyr Ser Ile Val 
65                  70                  75                  80  


Cys Val Val Gly Leu Phe Gly Asn Phe Leu Val Met Tyr Val Ile Val 
                85                  90                  95      


Arg Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile Tyr Ile Phe Asn Leu 
            100                 105                 110         


Ala Leu Ala Asp Ala Leu Ala Thr Ser Thr Leu Pro Phe Gln Ser Val 
        115                 120                 125             


Asn Tyr Leu Met Gly Thr Trp Pro Phe Gly Thr Ile Leu Cys Lys Ile 
    130                 135                 140                 


Val Ile Ser Ile Asp Tyr Tyr Asn Met Phe Thr Ser Ile Phe Thr Leu 
145                 150                 155                 160 


Cys Thr Met Ser Val Asp Arg Tyr Ile Ala Val Cys His Pro Val Lys 
                165                 170                 175     


Ala Leu Asp Phe Arg Thr Pro Arg Asn Ala Lys Ile Ile Asn Val Cys 
            180                 185                 190         


Asn Trp Ile Leu Ser Ser Ala Ile Gly Leu Pro Val Met Phe Met Ala 
        195                 200                 205             


Thr Thr Lys Tyr Arg Gln Gly Ser Ile Asp Cys Thr Leu Thr Phe Ser 
    210                 215                 220                 


His Pro Thr Trp Tyr Trp Glu Asn Leu Leu Lys Ile Cys Val Phe Ile 
225                 230                 235                 240 


Phe Ala Phe Ile Met Pro Val Leu Ile Ile Thr Val Cys Tyr Gly Leu 
                245                 250                 255     


Met Ile Leu Arg Leu Lys Ser Val Arg Met Leu Ser Gly Ser Lys Glu 
            260                 265                 270         


Lys Asp Arg Asn Leu Arg Arg Ile Thr Arg Met Val Leu Val Val Val 
        275                 280                 285             


Ala Val Phe Ile Val Cys Trp Thr Pro Ile His Ile Tyr Val Ile Ile 
    290                 295                 300                 


Lys Ala Leu Val Thr Ile Pro Glu Thr Thr Phe Gln Thr Val Ser Trp 
305                 310                 315                 320 


His Phe Cys Ile Ala Leu Gly Tyr Thr Asn Ser Cys Leu Asn Pro Val 
                325                 330                 335     


Leu Tyr Ala Phe Leu Asp Glu Asn Phe Lys Arg Cys Phe Arg Glu Phe 
            340                 345                 350         


Cys Ile Pro Thr Ser Ser Asn Ile Glu Gln Gln Asn Ser Thr Arg Ile 
        355                 360                 365             


Arg Gln Asn Thr Arg Asp His Pro Ser Thr Ala Asn Thr Val Asp Arg 
    370                 375                 380                 


Thr Asn His Gln Val Arg Ser Leu 
385                 390         


<210>  543
<211>  446
<212>  PRT
<213>  Homo sapiens

<400>  543

Met Asp Ser Ser Ala Ala Pro Thr Asn Ala Ser Asn Cys Thr Asp Ala 
1               5                   10                  15      


Leu Ala Tyr Ser Ser Cys Ser Pro Ala Pro Ser Pro Gly Ser Trp Val 
            20                  25                  30          


Asn Leu Ser His Leu Asp Gly Asn Leu Ser Asp Pro Cys Gly Pro Asn 
        35                  40                  45              


Arg Thr Asp Leu Gly Gly Arg Asp Ser Leu Cys Pro Pro Thr Gly Ser 
    50                  55                  60                  


Pro Ser Met Ile Thr Ala Ile Thr Ile Met Ala Leu Tyr Ser Ile Val 
65                  70                  75                  80  


Cys Val Val Gly Leu Phe Gly Asn Phe Leu Val Met Tyr Val Ile Val 
                85                  90                  95      


Arg Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile Tyr Ile Phe Asn Leu 
            100                 105                 110         


Ala Leu Ala Asp Ala Leu Ala Thr Ser Thr Leu Pro Phe Gln Ser Val 
        115                 120                 125             


Asn Tyr Leu Met Gly Thr Trp Pro Phe Gly Thr Ile Leu Cys Lys Ile 
    130                 135                 140                 


Val Ile Ser Ile Asp Tyr Tyr Asn Met Phe Thr Ser Ile Phe Thr Leu 
145                 150                 155                 160 


Cys Thr Met Ser Val Asp Arg Tyr Ile Ala Val Cys His Pro Val Lys 
                165                 170                 175     


Ala Leu Asp Phe Arg Thr Pro Arg Asn Ala Lys Ile Ile Asn Val Cys 
            180                 185                 190         


Asn Trp Ile Leu Ser Ser Ala Ile Gly Leu Pro Val Met Phe Met Ala 
        195                 200                 205             


Thr Thr Lys Tyr Arg Gln Gly Ser Ile Asp Cys Thr Leu Thr Phe Ser 
    210                 215                 220                 


His Pro Thr Trp Tyr Trp Glu Asn Leu Leu Lys Ile Cys Val Phe Ile 
225                 230                 235                 240 


Phe Ala Phe Ile Met Pro Val Leu Ile Ile Thr Val Cys Tyr Gly Leu 
                245                 250                 255     


Met Ile Leu Arg Leu Lys Ser Val Arg Met Leu Ser Gly Ser Lys Glu 
            260                 265                 270         


Lys Asp Arg Asn Leu Arg Arg Ile Thr Arg Met Val Leu Val Val Val 
        275                 280                 285             


Ala Val Phe Ile Val Cys Trp Thr Pro Ile His Ile Tyr Val Ile Ile 
    290                 295                 300                 


Lys Ala Leu Val Thr Ile Pro Glu Thr Thr Phe Gln Thr Val Ser Trp 
305                 310                 315                 320 


His Phe Cys Ile Ala Leu Gly Tyr Thr Asn Ser Cys Leu Asn Pro Val 
                325                 330                 335     


Leu Tyr Ala Phe Leu Asp Glu Asn Phe Lys Arg Cys Phe Arg Glu Phe 
            340                 345                 350         


Cys Ile Pro Thr Ser Ser Asn Ile Glu Gln Gln Asn Ser Thr Arg Ile 
        355                 360                 365             


Arg Gln Asn Thr Arg Asp His Pro Ser Thr Ala Asn Thr Val Asp Arg 
    370                 375                 380                 


Thr Asn His Gln Cys Leu Pro Ile Pro Ser Leu Ser Cys Trp Ala Leu 
385                 390                 395                 400 


Glu Gln Gly Cys Leu Val Val Tyr Pro Gly Pro Leu Gln Gly Pro Leu 
                405                 410                 415     


Val Arg Tyr Asp Leu Pro Ala Ile Leu His Ser Ser Cys Leu Arg Gly 
            420                 425                 430         


Asn Thr Ala Pro Ser Pro Ser Gly Gly Ala Phe Leu Leu Ser 
        435                 440                 445     


<210>  544
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  544

Met Glu Ala Pro Ala Glu Leu Leu Ala Ala Leu Pro Ala Leu Ala Thr 
1               5                   10                  15      


Ala Leu Ala Leu Leu Leu Ala Trp Leu Leu Val Arg Arg Gly Ala Ala 
            20                  25                  30          


Ala Ser Pro Glu Pro Ala Arg Ala Pro Pro Glu Pro Ala Pro Pro Ala 
        35                  40                  45              


Glu Ala Thr Gly Ala Pro Ala Pro Ser Arg Pro Cys Ala Pro Glu Pro 
    50                  55                  60                  


Ala Ala Ser Pro Ala Gly Pro Glu Glu Pro Gly Glu Pro Ala Gly Leu 
65                  70                  75                  80  


Gly Glu Leu Gly Glu Pro Ala Gly Pro Gly Glu Pro Glu Gly Pro Gly 
                85                  90                  95      


Asp Pro Ala Ala Ala Pro Ala Glu Ala Glu Glu Gln Ala Val Glu Ala 
            100                 105                 110         


Arg Gln Glu Glu Glu Gln Asp Leu Asp Gly Glu Lys Gly Pro Ser Ser 
        115                 120                 125             


Glu Gly Pro Glu Glu Glu Asp Gly Glu Gly Phe Ser Phe Lys Tyr Ser 
    130                 135                 140                 


Pro Gly Lys Leu Arg Gly Asn Gln Tyr Lys Lys Met Met Thr Lys Glu 
145                 150                 155                 160 


Glu Leu Glu Glu Glu Gln Arg Val Gln Lys Glu Gln Leu Ala Ala Ile 
                165                 170                 175     


Phe Lys Leu Met Lys Asp Asn Lys Glu Thr Phe Gly Glu Met Ser Asp 
            180                 185                 190         


Gly Asp Val Gln Glu Gln Leu Arg Leu Tyr Asp Met 
        195                 200                 


<210>  545
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  545

Met Glu Ala Pro Ala Glu Leu Leu Ala Ala Leu Pro Ala Leu Ala Thr 
1               5                   10                  15      


Ala Leu Ala Leu Leu Leu Ala Trp Leu Leu Val Arg Arg Gly Ala Ala 
            20                  25                  30          


Ala Ser Pro Glu Pro Ala Arg Ala Pro Pro Glu Pro Ala Pro Pro Ala 
        35                  40                  45              


Glu Ala Thr Gly Ala Pro Ala Pro Ser Arg Pro Cys Ala Pro Glu Pro 
    50                  55                  60                  


Ala Ala Ser Pro Ala Gly Pro Glu Glu Pro Gly Glu Pro Ala Gly Leu 
65                  70                  75                  80  


Gly Glu Leu Gly Glu Pro Ala Gly Pro Gly Glu Pro Glu Gly Pro Gly 
                85                  90                  95      


Asp Pro Ala Ala Ala Pro Ala Glu Ala Glu Glu Gln Ala Val Glu Ala 
            100                 105                 110         


Arg Gln Glu Glu Glu Gln Asp Leu Asp Gly Glu Lys Gly Pro Ser Ser 
        115                 120                 125             


Glu Gly Pro Glu Glu Glu Asp Gly Glu Gly Phe Ser Phe Lys Tyr Ser 
    130                 135                 140                 


Pro Gly Lys Leu Arg Gly Asn Gln Tyr Lys Lys Met Met Thr Lys Glu 
145                 150                 155                 160 


Glu Leu Glu Glu Glu Gln Arg Ile Glu Leu Thr Ser Asp Leu Thr Ser 
                165                 170                 175     


Leu 
    


<210>  546
<211>  658
<212>  PRT
<213>  Homo sapiens

<400>  546

Met Ile Pro Cys Arg Ala Ala Leu Thr Phe Ala Arg Cys Leu Ile Arg 
1               5                   10                  15      


Arg Lys Ile Val Thr Leu Asp Ser Leu Glu Asp Thr Lys Leu Cys Arg 
            20                  25                  30          


Cys Leu Ser Thr Met Asp Leu Ile Ala Leu Gly Val Gly Ser Thr Leu 
        35                  40                  45              


Gly Ala Gly Val Tyr Val Leu Ala Gly Glu Val Ala Lys Ala Asp Ser 
    50                  55                  60                  


Gly Pro Ser Ile Val Val Ser Phe Leu Ile Ala Ala Leu Ala Ser Val 
65                  70                  75                  80  


Met Ala Gly Leu Cys Tyr Ala Glu Phe Gly Ala Arg Val Pro Lys Thr 
                85                  90                  95      


Gly Ser Ala Tyr Leu Tyr Thr Tyr Val Thr Val Gly Glu Leu Trp Ala 
            100                 105                 110         


Phe Ile Thr Gly Trp Asn Leu Ile Leu Ser Tyr Val Ile Gly Thr Ser 
        115                 120                 125             


Ser Val Ala Arg Ala Trp Ser Gly Thr Phe Asp Glu Leu Leu Ser Lys 
    130                 135                 140                 


Gln Ile Gly Gln Phe Leu Arg Thr Tyr Phe Arg Met Asn Tyr Thr Gly 
145                 150                 155                 160 


Leu Ala Glu Tyr Pro Asp Phe Phe Ala Val Cys Leu Ile Leu Leu Leu 
                165                 170                 175     


Ala Gly Leu Leu Ser Phe Gly Val Lys Glu Ser Ala Trp Val Asn Lys 
            180                 185                 190         


Val Phe Thr Ala Val Asn Ile Leu Val Leu Leu Phe Val Met Val Ala 
        195                 200                 205             


Gly Phe Val Lys Gly Asn Val Ala Asn Trp Lys Ile Ser Glu Glu Phe 
    210                 215                 220                 


Leu Lys Asn Ile Ser Ala Ser Ala Arg Glu Pro Pro Ser Glu Asn Gly 
225                 230                 235                 240 


Thr Ser Ile Tyr Gly Ala Gly Gly Phe Met Pro Tyr Gly Phe Thr Gly 
                245                 250                 255     


Thr Leu Ala Gly Ala Ala Thr Cys Phe Tyr Ala Phe Val Gly Phe Asp 
            260                 265                 270         


Cys Ile Ala Thr Thr Gly Glu Glu Val Arg Asn Pro Gln Lys Ala Ile 
        275                 280                 285             


Pro Ile Gly Ile Val Thr Ser Leu Leu Val Cys Phe Met Ala Tyr Phe 
    290                 295                 300                 


Gly Val Ser Ala Ala Leu Thr Leu Met Met Pro Tyr Tyr Leu Leu Asp 
305                 310                 315                 320 


Glu Lys Ser Pro Leu Pro Val Ala Phe Glu Tyr Val Gly Trp Gly Pro 
                325                 330                 335     


Ala Lys Tyr Val Val Ala Ala Gly Ser Leu Cys Ala Leu Ser Thr Ser 
            340                 345                 350         


Leu Leu Gly Ser Ile Phe Pro Met Pro Arg Val Ile Tyr Ala Met Ala 
        355                 360                 365             


Glu Asp Gly Leu Leu Phe Lys Cys Leu Ala Gln Ile Asn Ser Lys Thr 
    370                 375                 380                 


Lys Thr Pro Ile Ile Ala Thr Leu Ser Ser Gly Ala Val Ala Ala Leu 
385                 390                 395                 400 


Met Ala Phe Leu Phe Asp Leu Lys Ala Leu Val Asp Met Met Ser Ile 
                405                 410                 415     


Gly Thr Leu Met Ala Tyr Ser Leu Val Ala Ala Cys Val Leu Ile Leu 
            420                 425                 430         


Arg Tyr Gln Pro Gly Leu Ser Tyr Asp Gln Pro Lys Cys Ser Pro Glu 
        435                 440                 445             


Lys Asp Gly Leu Gly Ser Ser Pro Arg Val Thr Ser Lys Ser Glu Ser 
    450                 455                 460                 


Gln Val Thr Met Leu Gln Arg Gln Gly Phe Ser Met Arg Thr Leu Phe 
465                 470                 475                 480 


Cys Pro Ser Leu Leu Pro Thr Gln Gln Ser Ala Ser Leu Val Ser Phe 
                485                 490                 495     


Leu Val Gly Phe Leu Ala Phe Leu Val Leu Gly Leu Ser Val Leu Thr 
            500                 505                 510         


Thr Tyr Gly Val His Ala Ile Thr Arg Leu Glu Ala Trp Ser Leu Ala 
        515                 520                 525             


Leu Leu Ala Leu Phe Leu Val Leu Phe Val Ala Ile Val Leu Thr Ile 
    530                 535                 540                 


Trp Arg Gln Pro Gln Asn Gln Gln Lys Val Ala Phe Met Val Pro Phe 
545                 550                 555                 560 


Leu Pro Phe Leu Pro Ala Phe Ser Ile Leu Val Asn Ile Tyr Leu Met 
                565                 570                 575     


Val Gln Leu Ser Ala Asp Thr Trp Val Arg Phe Ser Ile Trp Met Ala 
            580                 585                 590         


Ile Gly Phe Leu Ile Tyr Phe Ser Tyr Gly Ile Arg His Ser Leu Glu 
        595                 600                 605             


Gly His Leu Arg Asp Glu Asn Asn Glu Glu Asp Ala Tyr Pro Asp Asn 
    610                 615                 620                 


Val His Ala Ala Ala Glu Glu Lys Ser Ala Ile Gln Ala Asn Asp His 
625                 630                 635                 640 


His Pro Arg Asn Leu Ser Ser Pro Phe Ile Phe His Glu Lys Thr Ser 
                645                 650                 655     


Glu Phe 
        


<210>  547
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  547

Met Ser Ile Pro Leu Pro Leu Leu Gln Ile Tyr Thr Ser Asp Asn Tyr 
1               5                   10                  15      


Thr Glu Glu Met Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys 
            20                  25                  30          


Phe Arg Glu Glu Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile 
        35                  40                  45              


Tyr Ser Ile Ile Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile 
    50                  55                  60                  


Leu Val Met Gly Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr 
65                  70                  75                  80  


Arg Leu His Leu Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro 
                85                  90                  95      


Phe Trp Ala Val Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu 
            100                 105                 110         


Cys Lys Ala Val His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val 
        115                 120                 125             


Leu Ile Leu Ala Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His 
    130                 135                 140                 


Ala Thr Asn Ser Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val 
145                 150                 155                 160 


Tyr Val Gly Val Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe 
                165                 170                 175     


Ile Phe Ala Asn Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg 
            180                 185                 190         


Phe Tyr Pro Asn Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile 
        195                 200                 205             


Met Val Gly Leu Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys 
    210                 215                 220                 


Ile Ile Ile Ser Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys 
225                 230                 235                 240 


Ala Leu Lys Thr Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp 
                245                 250                 255     


Leu Pro Tyr Tyr Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu 
            260                 265                 270         


Ile Ile Lys Gln Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile 
        275                 280                 285             


Ser Ile Thr Glu Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile 
    290                 295                 300                 


Leu Tyr Ala Phe Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala 
305                 310                 315                 320 


Leu Thr Ser Val Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly 
                325                 330                 335     


Lys Arg Gly Gly His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser 
            340                 345                 350         


Phe His Ser Ser 
        355     


<210>  548
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  548

Met Arg Leu Ser Val Arg Arg Val Leu Leu Ala Ala Gly Cys Ala Leu 
1               5                   10                  15      


Val Leu Val Leu Ala Val Gln Leu Gly Gln Gln Val Leu Glu Cys Arg 
            20                  25                  30          


Ala Val Leu Ala Gly Leu Arg Ser Pro Arg Gly Ala Met Arg Pro Glu 
        35                  40                  45              


Gln Glu Glu Leu Val Met Val Gly Thr Asn His Val Glu Tyr Arg Tyr 
    50                  55                  60                  


Gly Lys Ala Met Pro Leu Ile Phe Val Gly Gly Val Pro Arg Ser Gly 
65                  70                  75                  80  


Thr Thr Leu Met Arg Ala Met Leu Asp Ala His Pro Glu Val Arg Cys 
                85                  90                  95      


Gly Glu Glu Thr Arg Ile Ile Pro Arg Val Leu Ala Met Arg Gln Ala 
            100                 105                 110         


Trp Ser Lys Ser Gly Arg Glu Lys Leu Arg Leu Asp Glu Ala Gly Val 
        115                 120                 125             


Thr Asp Glu Val Leu Asp Ala Ala Met Gln Ala Phe Ile Leu Glu Val 
    130                 135                 140                 


Ile Ala Lys His Gly Glu Pro Ala Arg Val Leu Cys Asn Lys Asp Pro 
145                 150                 155                 160 


Phe Thr Leu Lys Ser Ser Val Tyr Leu Ser Arg Leu Phe Pro Asn Ser 
                165                 170                 175     


Lys Phe Leu Leu Met Val Arg Asp Gly Arg Ala Ser Val His Ser Met 
            180                 185                 190         


Ile Thr Arg Lys Val Thr Ile Ala Gly Phe Asp Leu Ser Ser Tyr Arg 
        195                 200                 205             


Asp Cys Leu Thr Lys Trp Asn Lys Ala Ile Glu Val Met Tyr Ala Gln 
    210                 215                 220                 


Cys Met Glu Val Gly Lys Glu Lys Cys Leu Pro Val Tyr Tyr Glu Gln 
225                 230                 235                 240 


Leu Val Leu His Pro Arg Arg Ser Leu Lys Leu Ile Leu Asp Phe Leu 
                245                 250                 255     


Gly Ile Ala Trp Ser Asp Ala Val Leu His His Glu Asp Leu Ile Gly 
            260                 265                 270         


Lys Pro Gly Gly Val Ser Leu Ser Lys Ile Glu Arg Ser Thr Asp Gln 
        275                 280                 285             


Val Ile Lys Pro Val Asn Leu Glu Ala Leu Ser Lys Trp Thr Gly His 
    290                 295                 300                 


Ile Pro Gly Asp Val Val Arg Asp Met Ala Gln Ile Ala Pro Met Leu 
305                 310                 315                 320 


Ala Gln Leu Gly Tyr Asp Pro Tyr Ala Asn Pro Pro Asn Tyr Gly Asn 
                325                 330                 335     


Pro Asp Pro Phe Val Ile Asn Asn Thr Gln Arg Val Leu Lys Gly Asp 
            340                 345                 350         


Tyr Lys Thr Pro Ala Asn Leu Lys Gly Tyr Phe Gln Val Asn Gln Asn 
        355                 360                 365             


Ser Thr Ser Ser His Leu Gly Ser Ser 
    370                 375         


<210>  549
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  549

Met Ser Ser Pro Gln Arg Arg Lys Ala Met Pro Trp Ala Leu Ser Leu 
1               5                   10                  15      


Leu Leu Met Gly Phe Gln Leu Leu Val Thr Tyr Ala Trp Cys Ser Glu 
            20                  25                  30          


Glu Glu Met Gly Gly Asn Asn Lys Ile Val Gln Asp Pro Met Phe Leu 
        35                  40                  45              


Ala Thr Val Glu Phe Ala Leu Asn Thr Phe Asn Val Gln Ser Lys Glu 
    50                  55                  60                  


Glu His Ala Tyr Arg Leu Leu Arg Val Leu Ser Ser Trp Arg Glu Asp 
65                  70                  75                  80  


Ser Met Asp Arg Lys Trp Arg Gly Lys Met Val Phe Ser Met Asn Leu 
                85                  90                  95      


Gln Leu Arg Gln Thr Val Cys Arg Lys Phe Glu Asp Asp Ile Asp Asn 
            100                 105                 110         


Cys Pro Phe Gln Glu Ser Leu Glu Leu Asn Asn Val Arg Gln Gly Ile 
        115                 120                 125             


Ser Phe Pro Gln Val His Ser Cys Gly Cys Cys Met Gly Cys Gly Val 
    130                 135                 140                 


Gly Thr Gly Ala Ala Asp Lys Ala Ile Pro Arg Asp Lys Gly Lys 
145                 150                 155                 


<210>  550
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  550

Met Gly Trp Leu Cys Ser Gly Leu Leu Phe Pro Val Ser Cys Leu Val 
1               5                   10                  15      


Leu Leu Gln Val Ala Ser Ser Gly Asn Met Lys Val Leu Gln Glu Pro 
            20                  25                  30          


Thr Cys Val Ser Asp Tyr Met Ser Ile Ser Thr Cys Glu Trp Lys Met 
        35                  40                  45              


Asn Gly Pro Thr Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr Gln Leu 
    50                  55                  60                  


Val Phe Leu Leu Ser Glu Ala His Thr Cys Ile Pro Glu Asn Asn Gly 
65                  70                  75                  80  


Gly Ala Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser Ala 
                85                  90                  95      


Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Lys 
            100                 105                 110         


Gly Ser Phe Lys Pro Ser Glu His Val Lys Pro Arg Ala Pro Gly Asn 
        115                 120                 125             


Leu Thr Val His Thr Asn Val Ser Asp Thr Leu Leu Leu Thr Trp Ser 
    130                 135                 140                 


Asn Pro Tyr Pro Pro Asp Asn Tyr Leu Tyr Asn His Leu Thr Tyr Ala 
145                 150                 155                 160 


Val Asn Ile Trp Ser Glu Asn Asp Pro Ala Asp Phe Arg Ile Tyr Asn 
                165                 170                 175     


Val Thr Tyr Leu Glu Pro Ser Leu Arg Ile Ala Ala Ser Thr Leu Lys 
            180                 185                 190         


Ser Gly Ile Ser Tyr Arg Ala Arg Val Arg Ala Trp Ala Gln Cys Tyr 
        195                 200                 205             


Asn Thr Thr Trp Ser Glu Trp Ser Pro Ser Thr Lys Trp His Asn Ser 
    210                 215                 220                 


Asn Ile Cys 
225         


<210>  551
<211>  1474
<212>  PRT
<213>  Homo sapiens

<400>  551

Met Ala Arg Leu Ala Ala Val Leu Trp Asn Leu Cys Val Thr Ala Val 
1               5                   10                  15      


Leu Val Thr Ser Ala Thr Gln Gly Leu Ser Arg Ala Gly Leu Pro Phe 
            20                  25                  30          


Gly Leu Met Arg Arg Glu Leu Ala Cys Glu Gly Tyr Pro Ile Glu Leu 
        35                  40                  45              


Arg Cys Pro Gly Ser Asp Val Ile Met Val Glu Asn Ala Asn Tyr Gly 
    50                  55                  60                  


Arg Thr Asp Asp Lys Ile Cys Asp Ala Asp Pro Phe Gln Met Glu Asn 
65                  70                  75                  80  


Val Gln Cys Tyr Leu Pro Asp Ala Phe Lys Ile Met Ser Gln Arg Cys 
                85                  90                  95      


Asn Asn Arg Thr Gln Cys Val Val Val Ala Gly Ser Asp Ala Phe Pro 
            100                 105                 110         


Asp Pro Cys Pro Gly Thr Tyr Lys Tyr Leu Glu Val Gln Tyr Asp Cys 
        115                 120                 125             


Val Pro Tyr Lys Val Glu Gln Lys Val Phe Val Cys Pro Gly Thr Leu 
    130                 135                 140                 


Gln Lys Val Leu Glu Pro Thr Ser Thr His Glu Ser Glu His Gln Ser 
145                 150                 155                 160 


Gly Ala Trp Cys Lys Asp Pro Leu Gln Ala Gly Asp Arg Ile Tyr Val 
                165                 170                 175     


Met Pro Trp Ile Pro Tyr Arg Thr Asp Thr Leu Thr Glu Tyr Ala Ser 
            180                 185                 190         


Trp Glu Asp Tyr Val Ala Ala Arg His Thr Thr Thr Tyr Arg Leu Pro 
        195                 200                 205             


Asn Arg Val Asp Gly Thr Gly Phe Val Val Tyr Asp Gly Ala Val Phe 
    210                 215                 220                 


Tyr Asn Lys Glu Arg Thr Arg Asn Ile Val Lys Tyr Asp Leu Arg Thr 
225                 230                 235                 240 


Arg Ile Lys Ser Gly Glu Thr Val Ile Asn Thr Ala Asn Tyr His Asp 
                245                 250                 255     


Thr Ser Pro Tyr Arg Trp Gly Gly Lys Thr Asp Ile Asp Leu Ala Val 
            260                 265                 270         


Asp Glu Asn Gly Leu Trp Val Ile Tyr Ala Thr Glu Gly Asn Asn Gly 
        275                 280                 285             


Arg Leu Val Val Ser Gln Leu Asn Pro Tyr Thr Leu Arg Phe Glu Gly 
    290                 295                 300                 


Thr Trp Glu Thr Gly Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met 
305                 310                 315                 320 


Val Cys Gly Val Leu Tyr Val Leu Arg Ser Val Tyr Val Asp Asp Asp 
                325                 330                 335     


Ser Glu Ala Ala Gly Asn Arg Val Asp Tyr Ala Phe Asn Thr Asn Ala 
            340                 345                 350         


Asn Arg Glu Glu Pro Val Ser Leu Thr Phe Pro Asn Pro Tyr Gln Phe 
        355                 360                 365             


Ile Ser Ser Val Asp Tyr Asn Pro Arg Asp Asn Gln Leu Tyr Val Trp 
    370                 375                 380                 


Asn Asn Tyr Phe Val Val Arg Tyr Ser Leu Glu Phe Gly Pro Pro Asp 
385                 390                 395                 400 


Pro Ser Ala Gly Pro Ala Thr Ser Pro Pro Leu Ser Thr Thr Thr Thr 
                405                 410                 415     


Ala Arg Pro Thr Pro Leu Thr Ser Thr Ala Ser Pro Ala Ala Thr Thr 
            420                 425                 430         


Pro Leu Arg Arg Ala Pro Leu Thr Thr His Pro Val Gly Ala Ile Asn 
        435                 440                 445             


Gln Leu Gly Pro Asp Leu Pro Pro Ala Thr Ala Pro Val Pro Ser Thr 
    450                 455                 460                 


Arg Arg Pro Pro Ala Pro Asn Leu His Val Ser Pro Glu Leu Phe Cys 
465                 470                 475                 480 


Glu Pro Arg Glu Val Arg Arg Val Gln Trp Pro Ala Thr Gln Gln Gly 
                485                 490                 495     


Met Leu Val Glu Arg Pro Cys Pro Lys Gly Thr Arg Gly Ile Ala Ser 
            500                 505                 510         


Phe Gln Cys Leu Pro Ala Leu Gly Leu Trp Asn Pro Arg Gly Pro Asp 
        515                 520                 525             


Leu Ser Asn Cys Thr Ser Pro Trp Val Asn Gln Val Ala Gln Lys Ile 
    530                 535                 540                 


Lys Ser Gly Glu Asn Ala Ala Asn Ile Ala Ser Glu Leu Ala Arg His 
545                 550                 555                 560 


Thr Arg Gly Ser Ile Tyr Ala Gly Asp Val Ser Ser Ser Val Lys Leu 
                565                 570                 575     


Met Glu Gln Leu Leu Asp Ile Leu Asp Ala Gln Leu Gln Ala Leu Arg 
            580                 585                 590         


Pro Ile Glu Arg Glu Ser Ala Gly Lys Asn Tyr Asn Lys Met His Lys 
        595                 600                 605             


Arg Glu Arg Thr Cys Lys Asp Tyr Ile Lys Ala Val Val Glu Thr Val 
    610                 615                 620                 


Asp Asn Leu Leu Arg Pro Glu Ala Leu Glu Ser Trp Lys Asp Met Asn 
625                 630                 635                 640 


Ala Thr Glu Gln Val His Thr Ala Thr Met Leu Leu Asp Val Leu Glu 
                645                 650                 655     


Glu Gly Ala Phe Leu Leu Ala Asp Asn Val Arg Glu Pro Ala Arg Phe 
            660                 665                 670         


Leu Ala Ala Lys Glu Asn Val Val Leu Glu Val Thr Val Leu Asn Thr 
        675                 680                 685             


Glu Gly Gln Val Gln Glu Leu Val Phe Pro Gln Glu Glu Tyr Pro Arg 
    690                 695                 700                 


Lys Asn Ser Ile Gln Leu Ser Ala Lys Thr Ile Lys Gln Asn Ser Arg 
705                 710                 715                 720 


Asn Gly Val Val Lys Val Val Phe Ile Leu Tyr Asn Asn Leu Gly Leu 
                725                 730                 735     


Phe Leu Ser Thr Glu Asn Ala Thr Val Lys Leu Ala Gly Glu Ala Gly 
            740                 745                 750         


Pro Gly Gly Pro Gly Gly Ala Ser Leu Val Val Asn Ser Gln Val Ile 
        755                 760                 765             


Ala Ala Ser Ile Asn Lys Glu Ser Ser Arg Val Phe Leu Met Asp Pro 
    770                 775                 780                 


Val Ile Phe Thr Val Ala His Leu Glu Asp Lys Asn His Phe Asn Ala 
785                 790                 795                 800 


Asn Cys Ser Phe Trp Asn Tyr Ser Glu Arg Ser Met Leu Gly Tyr Trp 
                805                 810                 815     


Ser Thr Gln Gly Cys Arg Leu Val Glu Ser Asn Lys Thr His Thr Thr 
            820                 825                 830         


Cys Ala Cys Ser His Leu Thr Asn Phe Ala Val Leu Met Ala His Arg 
        835                 840                 845             


Glu Ile Tyr Gln Gly Arg Ile Asn Glu Leu Leu Leu Ser Val Ile Thr 
    850                 855                 860                 


Trp Val Gly Ile Val Ile Ser Leu Val Cys Leu Ala Ile Cys Ile Ser 
865                 870                 875                 880 


Thr Phe Cys Phe Leu Arg Gly Leu Gln Thr Asp Arg Asn Thr Ile His 
                885                 890                 895     


Lys Asn Leu Cys Ile Asn Leu Phe Leu Ala Glu Leu Leu Phe Leu Val 
            900                 905                 910         


Gly Ile Asp Lys Thr Gln Tyr Glu Ile Ala Cys Pro Ile Phe Ala Gly 
        915                 920                 925             


Leu Leu His Tyr Phe Phe Leu Ala Ala Phe Ser Trp Leu Cys Leu Glu 
    930                 935                 940                 


Gly Val His Leu Tyr Leu Leu Leu Val Glu Val Phe Glu Ser Glu Tyr 
945                 950                 955                 960 


Ser Arg Thr Lys Tyr Tyr Tyr Leu Gly Gly Tyr Cys Phe Pro Ala Leu 
                965                 970                 975     


Val Val Gly Ile Ala Ala Ala Ile Asp Tyr Arg Ser Tyr Gly Thr Glu 
            980                 985                 990         


Lys Ala Cys Trp Leu Arg Val Asp  Asn Tyr Phe Ile Trp  Ser Phe Ile 
        995                 1000                 1005             


Gly Pro  Val Ser Phe Val Ile  Val Val Asn Leu Val  Phe Leu Met 
    1010                 1015                 1020             


Val Thr  Leu His Lys Met Ile  Arg Ser Ser Ser Val  Leu Lys Pro 
    1025                 1030                 1035             


Asp Ser  Ser Arg Leu Asp Asn  Ile Lys Ser Trp Ala  Leu Gly Ala 
    1040                 1045                 1050             


Ile Ala  Leu Leu Phe Leu Leu  Gly Leu Thr Trp Ala  Phe Gly Leu 
    1055                 1060                 1065             


Leu Phe  Ile Asn Lys Glu Ser  Val Val Met Ala Tyr  Leu Phe Thr 
    1070                 1075                 1080             


Thr Phe  Asn Ala Phe Gln Gly  Val Phe Ile Phe Val  Phe His Cys 
    1085                 1090                 1095             


Ala Leu  Gln Lys Lys Val His  Lys Glu Tyr Ser Lys  Cys Leu Arg 
    1100                 1105                 1110             


His Ser  Tyr Cys Cys Ile Arg  Ser Pro Pro Gly Gly  Thr His Gly 
    1115                 1120                 1125             


Ser Leu  Lys Thr Ser Ala Met  Arg Ser Asn Thr Arg  Tyr Tyr Thr 
    1130                 1135                 1140             


Gly Thr  Gln Ser Arg Ile Arg  Arg Met Trp Asn Asp  Thr Val Arg 
    1145                 1150                 1155             


Lys Gln  Thr Glu Ser Ser Phe  Met Ala Gly Asp Ile  Asn Ser Thr 
    1160                 1165                 1170             


Pro Thr  Leu Asn Arg Gly Thr  Met Gly Asn His Leu  Leu Thr Asn 
    1175                 1180                 1185             


Pro Val  Leu Gln Pro Arg Gly  Gly Thr Ser Pro Tyr  Asn Thr Leu 
    1190                 1195                 1200             


Ile Ala  Glu Ser Val Gly Phe  Asn Pro Ser Ser Pro  Pro Val Phe 
    1205                 1210                 1215             


Asn Ser  Pro Gly Ser Tyr Arg  Glu Pro Lys His Pro  Leu Gly Gly 
    1220                 1225                 1230             


Arg Glu  Ala Cys Gly Met Asp  Thr Leu Pro Leu Asn  Gly Asn Phe 
    1235                 1240                 1245             


Asn Asn  Ser Tyr Ser Leu Arg  Ser Gly Asp Phe Pro  Pro Gly Asp 
    1250                 1255                 1260             


Gly Gly  Pro Glu Pro Pro Arg  Gly Arg Asn Leu Ala  Asp Ala Ala 
    1265                 1270                 1275             


Ala Phe  Glu Lys Met Ile Ile  Ser Glu Leu Val His  Asn Asn Leu 
    1280                 1285                 1290             


Arg Gly  Ser Ser Ser Ala Ala  Lys Gly Pro Pro Pro  Pro Glu Pro 
    1295                 1300                 1305             


Pro Val  Pro Pro Val Pro Gly  Gly Gly Gly Glu Glu  Glu Ala Gly 
    1310                 1315                 1320             


Gly Pro  Gly Gly Ala Asp Arg  Ala Glu Ile Glu Leu  Leu Tyr Lys 
    1325                 1330                 1335             


Ala Leu  Glu Glu Pro Leu Leu  Leu Pro Arg Ala Gln  Ser Val Leu 
    1340                 1345                 1350             


Tyr Gln  Ser Asp Leu Asp Glu  Ser Glu Ser Cys Thr  Ala Glu Asp 
    1355                 1360                 1365             


Gly Ala  Thr Ser Arg Pro Leu  Ser Ser Pro Pro Gly  Arg Asp Ser 
    1370                 1375                 1380             


Leu Tyr  Ala Ser Gly Ala Asn  Leu Arg Asp Ser Pro  Ser Tyr Pro 
    1385                 1390                 1395             


Asp Ser  Ser Pro Glu Gly Pro  Ser Glu Ala Leu Pro  Pro Pro Pro 
    1400                 1405                 1410             


Pro Ala  Pro Pro Gly Pro Pro  Glu Ile Tyr Tyr Thr  Ser Arg Pro 
    1415                 1420                 1425             


Pro Ala  Leu Val Ala Arg Asn  Pro Leu Gln Gly Tyr  Tyr Gln Val 
    1430                 1435                 1440             


Arg Arg  Pro Ser His Glu Gly  Tyr Leu Ala Ala Pro  Gly Leu Glu 
    1445                 1450                 1455             


Gly Pro  Gly Pro Asp Gly Asp  Gly Gln Met Gln Leu  Val Thr Ser 
    1460                 1465                 1470             


Leu 
    


<210>  552
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  552

Met Ser Thr Ser Ser Ser Ser Ser Trp Asp Asn Leu Leu Glu Ser Leu 
1               5                   10                  15      


Ser Leu Ser Thr Val Trp Asn Trp Ile Gln Ala Ser Phe Leu Gly Glu 
            20                  25                  30          


Thr Ser Ala Pro Gln Gln Thr Ser Leu Gly Leu Leu Asp Asn Leu Ala 
        35                  40                  45              


Pro Ala Val Gln Ile Ile Leu Arg Ile Ser Phe Leu Ile Leu Leu Gly 
    50                  55                  60                  


Ile Gly Ile Tyr Ala Leu Trp Lys Arg Ser Ile Gln Ser Ile Gln Lys 
65                  70                  75                  80  


Thr Leu Leu Phe Val Ile Thr Leu Tyr Lys Leu Tyr Lys Lys Gly Ser 
                85                  90                  95      


His Ile Phe Glu Ala Leu Leu Ala Asn Pro Glu Gly Ser Gly Leu Arg 
            100                 105                 110         


Ile Gln Asp Asn Asn Asn Leu Phe Leu Ser Leu Gly Leu Gln Glu Lys 
        115                 120                 125             


Ile Leu Lys Lys Leu Lys Thr Val Glu Asn Lys Met Lys Asn Leu Glu 
    130                 135                 140                 


Gly Ile Ile Val Ala Gln Lys Pro Ala Thr Lys Arg Asp Cys Ser Ser 
145                 150                 155                 160 


Glu Pro Tyr Cys Ser Cys Ser Asp Cys Gln Ser Pro Leu Ser Thr Ser 
                165                 170                 175     


Gly Phe Thr Ser Pro Ile 
            180         


<210>  553
<211>  4557
<212>  PRT
<213>  Homo sapiens

<400>  553

Met Asp Ile Ile Met Gly His Cys Val Gly Thr Arg Pro Pro Ala Cys 
1               5                   10                  15      


Cys Leu Ile Leu Leu Leu Phe Lys Leu Leu Ala Thr Val Ser Gln Gly 
            20                  25                  30          


Leu Pro Gly Thr Gly Pro Leu Gly Phe His Phe Thr His Ser Ile Tyr 
        35                  40                  45              


Asn Ala Thr Val Tyr Glu Asn Ser Ala Ala Arg Thr Tyr Val Asn Ser 
    50                  55                  60                  


Gln Ser Arg Met Gly Ile Thr Leu Ile Asp Leu Ser Trp Asp Ile Lys 
65                  70                  75                  80  


Tyr Arg Ile Val Ser Gly Asp Glu Glu Gly Phe Phe Lys Ala Glu Glu 
                85                  90                  95      


Val Ile Ile Ala Asp Phe Cys Phe Leu Arg Ile Arg Thr Lys Gly Gly 
            100                 105                 110         


Asn Ser Ala Ile Leu Asn Arg Glu Ile Gln Asp Asn Tyr Leu Leu Ile 
        115                 120                 125             


Val Lys Gly Ser Val Arg Gly Glu Asp Leu Glu Ala Trp Thr Lys Val 
    130                 135                 140                 


Asn Ile Gln Val Leu Asp Met Asn Asp Leu Arg Pro Leu Phe Ser Pro 
145                 150                 155                 160 


Thr Thr Tyr Ser Val Thr Ile Ala Glu Ser Thr Pro Leu Arg Thr Ser 
                165                 170                 175     


Val Ala Gln Val Thr Ala Thr Asp Ala Asp Ile Gly Ser Asn Gly Glu 
            180                 185                 190         


Phe Tyr Tyr Tyr Phe Lys Asn Lys Val Asp Leu Phe Ser Val His Pro 
        195                 200                 205             


Thr Ser Gly Val Ile Ser Leu Ser Gly Arg Leu Asn Tyr Asp Glu Lys 
    210                 215                 220                 


Asn Arg Tyr Asp Leu Glu Ile Leu Ala Val Asp Arg Gly Met Lys Leu 
225                 230                 235                 240 


Tyr Gly Asn Asn Gly Val Ser Ser Thr Ala Lys Leu Tyr Val His Ile 
                245                 250                 255     


Glu Arg Ile Asn Glu His Ala Pro Thr Ile His Val Val Thr His Val 
            260                 265                 270         


Pro Phe Ser Leu Glu Lys Glu Pro Thr Tyr Ala Val Val Thr Val Asp 
        275                 280                 285             


Asp Leu Asp Asp Gly Ala Asn Gly Glu Ile Glu Ser Val Ser Ile Val 
    290                 295                 300                 


Ala Gly Asp Pro Leu Asp Gln Phe Phe Leu Ala Lys Glu Gly Lys Trp 
305                 310                 315                 320 


Leu Asn Glu Tyr Lys Ile Lys Glu Arg Lys Gln Ile Asp Trp Glu Ser 
                325                 330                 335     


Phe Pro Tyr Gly Tyr Asn Leu Thr Leu Gln Ala Lys Asp Lys Gly Ser 
            340                 345                 350         


Pro Gln Lys Cys Ser Ala Leu Lys Ala Val Tyr Ile Gly Asn Pro Thr 
        355                 360                 365             


Arg Asp Thr Val Pro Ile Arg Phe Glu Lys Glu Val Tyr Asp Val Ser 
    370                 375                 380                 


Ile Ser Glu Phe Ser Pro Pro Gly Val Val Val Ala Ile Val Lys Leu 
385                 390                 395                 400 


Ser Pro Glu Pro Ile Asp Val Glu Tyr Lys Leu Ser Pro Gly Glu Asp 
                405                 410                 415     


Ala Val Tyr Phe Lys Ile Asn Pro Arg Ser Gly Leu Ile Val Thr Ala 
            420                 425                 430         


Arg Pro Leu Asn Thr Val Lys Lys Glu Val Tyr Lys Leu Glu Val Thr 
        435                 440                 445             


Asn Lys Glu Gly Asp Leu Lys Ala Gln Val Thr Ile Ser Ile Glu Asp 
    450                 455                 460                 


Ala Asn Asp His Thr Pro Glu Phe Gln Gln Pro Leu Tyr Asp Ala Tyr 
465                 470                 475                 480 


Val Asn Glu Ser Val Pro Val Gly Thr Ser Val Leu Thr Val Ser Ala 
                485                 490                 495     


Ser Asp Lys Asp Lys Gly Glu Asn Gly Tyr Ile Thr Tyr Ser Ile Ala 
            500                 505                 510         


Ser Leu Asn Leu Leu Pro Phe Val Ile Asn Gln Phe Thr Gly Val Ile 
        515                 520                 525             


Ser Thr Thr Glu Glu Leu Asp Phe Glu Ser Ser Pro Glu Ile Tyr Arg 
    530                 535                 540                 


Phe Ile Val Arg Ala Ser Asp Trp Gly Ser Pro Tyr Arg His Glu Ser 
545                 550                 555                 560 


Glu Val Asn Val Thr Ile Arg Ile Gly Asn Val Asn Asp Asn Ser Pro 
                565                 570                 575     


Leu Phe Glu Lys Val Ala Cys Gln Gly Val Ile Ser Tyr Asp Phe Pro 
            580                 585                 590         


Val Gly Gly His Ile Thr Ala Val Ser Ala Ile Asp Ile Asp Glu Leu 
        595                 600                 605             


Glu Leu Val Lys Tyr Lys Ile Ile Ser Gly Asn Glu Leu Gly Phe Phe 
    610                 615                 620                 


Tyr Leu Asn Pro Asp Ser Gly Val Leu Gln Leu Lys Lys Ser Leu Thr 
625                 630                 635                 640 


Asn Ser Gly Ile Lys Asn Gly Asn Phe Ala Leu Arg Ile Thr Ala Thr 
                645                 650                 655     


Asp Gly Glu Asn Leu Ala Asp Pro Met Ser Ile Asn Ile Ser Val Leu 
            660                 665                 670         


His Gly Lys Val Ser Ser Lys Ser Phe Ser Cys Arg Glu Thr Arg Val 
        675                 680                 685             


Ala Gln Lys Leu Ala Glu Lys Leu Leu Ile Lys Ala Lys Ala Asn Gly 
    690                 695                 700                 


Lys Leu Asn Leu Glu Asp Gly Phe Leu Asp Phe Tyr Ser Ile Asn Arg 
705                 710                 715                 720 


Gln Gly Pro Tyr Phe Asp Lys Ser Phe Pro Ser Asp Val Ala Val Lys 
                725                 730                 735     


Glu Asp Leu Pro Val Gly Ala Asn Ile Leu Lys Ile Lys Ala Tyr Asp 
            740                 745                 750         


Ala Asp Ser Gly Phe Asn Gly Lys Val Leu Phe Thr Ile Ser Asp Gly 
        755                 760                 765             


Asn Thr Asp Ser Cys Phe Asn Ile Asp Met Glu Thr Gly Gln Leu Lys 
    770                 775                 780                 


Val Leu Met Pro Met Asp Arg Glu His Thr Asp Leu Tyr Leu Leu Asn 
785                 790                 795                 800 


Ile Thr Ile Tyr Asp Leu Gly Asn Pro Gln Lys Ser Ser Trp Arg Leu 
                805                 810                 815     


Leu Thr Ile Asn Val Glu Asp Ala Asn Asp Asn Ser Pro Val Phe Ile 
            820                 825                 830         


Gln Asp Ser Tyr Ser Val Asn Ile Leu Glu Ser Ser Gly Ile Gly Thr 
        835                 840                 845             


Glu Ile Ile Gln Val Glu Ala Arg Asp Lys Asp Leu Gly Ser Asn Gly 
    850                 855                 860                 


Glu Val Thr Tyr Ser Val Leu Thr Asp Thr Gln Gln Phe Ala Ile Asn 
865                 870                 875                 880 


Ser Ser Thr Gly Ile Val Tyr Val Ala Asp Gln Leu Asp Arg Glu Ser 
                885                 890                 895     


Lys Ala Asn Tyr Ser Leu Lys Ile Glu Ala Arg Asp Lys Ala Glu Ser 
            900                 905                 910         


Gly Gln Gln Leu Phe Ser Val Val Thr Leu Lys Val Phe Leu Asp Asp 
        915                 920                 925             


Val Asn Asp Cys Ser Pro Ala Phe Ile Pro Ser Ser Tyr Ser Val Lys 
    930                 935                 940                 


Val Leu Glu Asp Leu Pro Val Gly Thr Val Ile Ala Trp Leu Glu Thr 
945                 950                 955                 960 


His Asp Pro Asp Leu Gly Leu Gly Gly Gln Val Arg Tyr Ser Leu Val 
                965                 970                 975     


Asn Asp Tyr Asn Gly Arg Phe Glu Ile Asp Lys Ala Ser Gly Ala Ile 
            980                 985                 990         


Arg Leu Ser Lys Glu Leu Asp Tyr  Glu Lys Gln Gln Phe  Tyr Asn Leu 
        995                 1000                 1005             


Thr Val  Arg Ala Lys Asp Lys  Gly Arg Pro Val Ser  Leu Ser Ser 
    1010                 1015                 1020             


Val Ser  Phe Val Glu Val Glu  Val Val Asp Val Asn  Glu Asn Leu 
    1025                 1030                 1035             


His Thr  Pro Tyr Phe Pro Asp  Phe Ala Val Val Gly  Ser Val Lys 
    1040                 1045                 1050             


Glu Asn  Ser Arg Ile Gly Thr  Ser Val Leu Gln Val  Thr Ala Arg 
    1055                 1060                 1065             


Asp Glu  Asp Ser Gly Arg Asp  Gly Glu Ile Gln Tyr  Ser Ile Arg 
    1070                 1075                 1080             


Asp Gly  Ser Gly Leu Gly Arg  Phe Ser Ile Asp Asp  Glu Ser Gly 
    1085                 1090                 1095             


Val Ile  Thr Ala Ala Asp Ile  Leu Asp Arg Glu Thr  Met Gly Ser 
    1100                 1105                 1110             


Tyr Trp  Leu Thr Val Tyr Ala  Thr Asp Arg Gly Val  Val Pro Leu 
    1115                 1120                 1125             


Tyr Ser  Thr Ile Glu Val Tyr  Ile Glu Val Glu Asp  Val Asn Asp 
    1130                 1135                 1140             


Asn Ala  Pro Leu Thr Ser Glu  Pro Ile Tyr Tyr Pro  Val Val Met 
    1145                 1150                 1155             


Glu Asn  Ser Pro Lys Asp Val  Ser Val Ile Gln Ile  Gln Ala Glu 
    1160                 1165                 1170             


Asp Pro  Asp Ser Ser Ser Asn  Glu Lys Leu Thr Tyr  Arg Ile Thr 
    1175                 1180                 1185             


Ser Gly  Asn Pro Gln Asn Phe  Phe Ala Ile Asn Ile  Lys Thr Gly 
    1190                 1195                 1200             


Leu Ile  Thr Thr Thr Ser Arg  Lys Leu Asp Arg Glu  Gln Gln Ala 
    1205                 1210                 1215             


Glu His  Phe Leu Glu Val Thr  Val Thr Asp Gly Gly  Pro Ser Pro 
    1220                 1225                 1230             


Lys Gln  Ser Thr Ile Trp Val  Val Val Gln Val Leu  Asp Glu Asn 
    1235                 1240                 1245             


Asp Asn  Lys Pro Gln Phe Pro  Glu Lys Val Tyr Gln  Ile Lys Leu 
    1250                 1255                 1260             


Pro Glu  Arg Asp Arg Lys Lys  Arg Gly Glu Pro Ile  Tyr Arg Ala 
    1265                 1270                 1275             


Phe Ala  Phe Asp Arg Asp Glu  Gly Pro Asn Ala Glu  Ile Ser Tyr 
    1280                 1285                 1290             


Ser Ile  Val Asp Gly Asn Asp  Asp Gly Lys Phe Phe  Ile Asp Pro 
    1295                 1300                 1305             


Lys Thr  Gly Met Val Ser Ser  Arg Lys Gln Phe Thr  Ala Gly Ser 
    1310                 1315                 1320             


Tyr Asp  Ile Leu Thr Ile Lys  Ala Val Asp Asn Gly  Arg Pro Gln 
    1325                 1330                 1335             


Lys Ser  Ser Thr Ala Arg Leu  His Ile Glu Trp Ile  Lys Lys Pro 
    1340                 1345                 1350             


Pro Pro  Ser Pro Ile Pro Leu  Thr Phe Asp Glu Pro  Phe Tyr Asn 
    1355                 1360                 1365             


Phe Thr  Val Met Glu Ser Asp  Arg Val Thr Glu Ile  Val Gly Val 
    1370                 1375                 1380             


Val Ser  Val Gln Pro Ala Asn  Thr Pro Leu Trp Phe  Asp Ile Val 
    1385                 1390                 1395             


Gly Gly  Asn Phe Asp Ser Ala  Phe Asp Ala Glu Lys  Gly Val Gly 
    1400                 1405                 1410             


Thr Ile  Val Ile Ala Lys Pro  Leu Asp Ala Glu Gln  Arg Ser Ile 
    1415                 1420                 1425             


Tyr Asn  Met Ser Val Glu Val  Thr Asp Gly Thr Asn  Val Ala Val 
    1430                 1435                 1440             


Thr Gln  Val Phe Ile Lys Val  Leu Asp Asn Asn Asp  Asn Gly Pro 
    1445                 1450                 1455             


Glu Phe  Ser Gln Pro Asn Tyr  Asp Val Thr Ile Ser  Glu Asp Val 
    1460                 1465                 1470             


Leu Pro  Asp Thr Glu Ile Leu  Gln Ile Glu Ala Thr  Asp Arg Asp 
    1475                 1480                 1485             


Glu Lys  His Lys Leu Ser Tyr  Thr Val His Ser Ser  Ile Asp Ser 
    1490                 1495                 1500             


Ile Ser  Met Arg Lys Phe Arg  Ile Asp Pro Ser Thr  Gly Val Leu 
    1505                 1510                 1515             


Tyr Thr  Ala Glu Arg Leu Asp  His Glu Ala Gln Asp  Lys His Ile 
    1520                 1525                 1530             


Leu Asn  Ile Met Val Arg Asp  Gln Glu Phe Pro Tyr  Arg Arg Asn 
    1535                 1540                 1545             


Leu Ala  Arg Val Ile Val Asn  Val Glu Asp Ala Asn  Asp His Ser 
    1550                 1555                 1560             


Pro Tyr  Phe Thr Asn Pro Leu  Tyr Glu Ala Ser Val  Phe Glu Ser 
    1565                 1570                 1575             


Ala Ala  Leu Gly Ser Ala Val  Leu Gln Val Thr Ala  Leu Asp Lys 
    1580                 1585                 1590             


Asp Lys  Gly Glu Asn Ala Glu  Leu Ile Tyr Thr Ile  Glu Ala Gly 
    1595                 1600                 1605             


Asn Thr  Gly Asn Met Phe Lys  Ile Glu Pro Val Leu  Gly Ile Ile 
    1610                 1615                 1620             


Thr Ile  Cys Lys Glu Pro Asp  Met Thr Thr Met Gly  Gln Phe Val 
    1625                 1630                 1635             


Leu Ser  Ile Lys Val Thr Asp  Gln Gly Ser Pro Pro  Met Ser Ala 
    1640                 1645                 1650             


Thr Ala  Ile Val Arg Ile Ser  Val Thr Met Ser Asp  Asn Ser His 
    1655                 1660                 1665             


Pro Lys  Phe Ile His Lys Asp  Tyr Gln Ala Glu Val  Asn Glu Asn 
    1670                 1675                 1680             


Val Asp  Ile Gly Thr Ser Val  Ile Leu Ile Ser Ala  Ile Ser Gln 
    1685                 1690                 1695             


Ser Thr  Leu Ile Tyr Glu Val  Lys Asp Gly Asp Ile  Asn Gly Ile 
    1700                 1705                 1710             


Phe Thr  Ile Asn Pro Tyr Ser  Gly Val Ile Thr Thr  Gln Lys Ala 
    1715                 1720                 1725             


Leu Asp  Tyr Glu Arg Thr Ser  Ser Tyr Gln Leu Ile  Ile Gln Ala 
    1730                 1735                 1740             


Thr Asn  Met Ala Gly Met Ala  Ser Asn Ala Thr Val  Asn Ile Gln 
    1745                 1750                 1755             


Ile Val  Asp Glu Asn Asp Asn  Ala Pro Val Phe Leu  Phe Ser Gln 
    1760                 1765                 1770             


Tyr Ser  Gly Ser Leu Ser Glu  Ala Ala Pro Ile Asn  Ser Ile Val 
    1775                 1780                 1785             


Arg Ser  Leu Asp Asn Ser Pro  Leu Val Ile Arg Ala  Thr Asp Ala 
    1790                 1795                 1800             


Asp Ser  Asn Arg Asn Ala Leu  Leu Val Tyr Gln Ile  Val Glu Ser 
    1805                 1810                 1815             


Thr Ala  Lys Lys Phe Phe Thr  Val Asp Ser Ser Thr  Gly Ala Ile 
    1820                 1825                 1830             


Arg Thr  Ile Ala Asn Leu Asp  His Glu Thr Ile Ala  His Phe His 
    1835                 1840                 1845             


Phe His  Val His Val Arg Asp  Ser Gly Ser Pro Gln  Leu Thr Ala 
    1850                 1855                 1860             


Glu Ser  Pro Val Glu Val Asn  Ile Glu Val Thr Asp  Val Asn Asp 
    1865                 1870                 1875             


Asn Pro  Pro Val Phe Thr Gln  Ala Val Phe Glu Thr  Ile Leu Leu 
    1880                 1885                 1890             


Leu Pro  Thr Tyr Val Gly Val  Glu Val Leu Lys Val  Ser Ala Thr 
    1895                 1900                 1905             


Asp Pro  Asp Ser Glu Val Pro  Pro Glu Leu Thr Tyr  Ser Leu Met 
    1910                 1915                 1920             


Glu Gly  Ser Leu Asp His Phe  Leu Ile Asp Ser Asn  Ser Gly Val 
    1925                 1930                 1935             


Leu Thr  Ile Lys Asn Asn Asn  Leu Ser Lys Asp His  Tyr Met Leu 
    1940                 1945                 1950             


Ile Val  Lys Val Ser Asp Gly  Lys Phe Tyr Ser Thr  Ser Met Val 
    1955                 1960                 1965             


Thr Ile  Met Val Lys Glu Ala  Met Asp Ser Gly Leu  His Phe Thr 
    1970                 1975                 1980             


Gln Ser  Phe Tyr Ser Thr Ser  Ile Ser Glu Asn Asn  Thr Asn Ile 
    1985                 1990                 1995             


Thr Lys  Val Ala Ile Val Asn  Ala Val Gly Asn Arg  Leu Asn Glu 
    2000                 2005                 2010             


Pro Leu  Lys Tyr Ser Ile Leu  Asn Pro Gly Asn Lys  Phe Lys Ile 
    2015                 2020                 2025             


Lys Ser  Thr Ser Gly Val Ile  Gln Thr Thr Gly Val  Pro Phe Asp 
    2030                 2035                 2040             


Arg Glu  Glu Gln Glu Leu Tyr  Glu Leu Val Val Glu  Ala Ser Arg 
    2045                 2050                 2055             


Glu Leu  Asp His Leu Arg Val  Ala Arg Val Val Val  Arg Val Asn 
    2060                 2065                 2070             


Ile Glu  Asp Ile Asn Asp Asn  Ser Pro Val Phe Val  Gly Leu Pro 
    2075                 2080                 2085             


Tyr Tyr  Ala Ala Val Gln Val  Asp Ala Glu Pro Gly  Thr Leu Ile 
    2090                 2095                 2100             


Tyr Gln  Val Thr Ala Ile Asp  Lys Asp Lys Gly Pro  Asn Gly Glu 
    2105                 2110                 2115             


Val Thr  Tyr Val Leu Gln Asp  Asp Tyr Gly His Phe  Glu Ile Asn 
    2120                 2125                 2130             


Pro Asn  Ser Gly Asn Val Ile  Leu Lys Glu Ala Phe  Asn Ser Asp 
    2135                 2140                 2145             


Leu Ser  Asn Ile Glu Tyr Gly  Val Thr Ile Leu Ala  Lys Asp Gly 
    2150                 2155                 2160             


Gly Lys  Pro Ser Leu Ser Thr  Ser Val Glu Leu Pro  Ile Thr Ile 
    2165                 2170                 2175             


Val Asn  Lys Ala Met Pro Val  Phe Asp Lys Pro Phe  Tyr Thr Ala 
    2180                 2185                 2190             


Ser Val  Asn Glu Asp Ile Arg  Met Asn Thr Pro Ile  Leu Ser Ile 
    2195                 2200                 2205             


Asn Ala  Thr Ser Pro Glu Gly  Gln Gly Ile Ile Tyr  Ile Ile Ile 
    2210                 2215                 2220             


Asp Gly  Asp Pro Phe Lys Gln  Phe Asn Ile Asp Phe  Asp Thr Gly 
    2225                 2230                 2235             


Val Leu  Lys Val Val Ser Pro  Leu Asp Tyr Glu Val  Thr Ser Ala 
    2240                 2245                 2250             


Tyr Lys  Leu Thr Ile Arg Ala  Ser Asp Ala Leu Thr  Gly Ala Arg 
    2255                 2260                 2265             


Ala Glu  Val Thr Val Asp Leu  Leu Val Asn Asp Val  Asn Asp Asn 
    2270                 2275                 2280             


Pro Pro  Ile Phe Asp Gln Pro  Thr Tyr Asn Thr Thr  Leu Ser Glu 
    2285                 2290                 2295             


Ala Ser  Leu Ile Gly Thr Pro  Val Leu Gln Val Val  Ser Ile Asp 
    2300                 2305                 2310             


Ala Asp  Ser Glu Asn Asn Lys  Met Val His Tyr Gln  Ile Val Gln 
    2315                 2320                 2325             


Asp Thr  Tyr Asn Ser Thr Asp  Tyr Phe His Ile Asp  Ser Ser Ser 
    2330                 2335                 2340             


Gly Leu  Ile Leu Thr Ala Arg  Met Leu Asp His Glu  Leu Val Gln 
    2345                 2350                 2355             


His Cys  Thr Leu Lys Val Arg  Ser Ile Asp Ser Gly  Phe Pro Ser 
    2360                 2365                 2370             


Leu Ser  Ser Glu Val Leu Val  His Ile Tyr Ile Ser  Asp Val Asn 
    2375                 2380                 2385             


Asp Asn  Pro Pro Val Phe Asn  Gln Leu Ile Tyr Glu  Ser Tyr Val 
    2390                 2395                 2400             


Ser Glu  Leu Ala Pro Arg Gly  His Phe Val Thr Cys  Val Gln Ala 
    2405                 2410                 2415             


Ser Asp  Ala Asp Ser Ser Asp  Phe Asp Arg Leu Glu  Tyr Ser Ile 
    2420                 2425                 2430             


Leu Ser  Gly Asn Asp Arg Thr  Ser Phe Leu Met Asp  Ser Lys Ser 
    2435                 2440                 2445             


Gly Val  Ile Thr Leu Ser Asn  His Arg Lys Gln Arg  Met Glu Pro 
    2450                 2455                 2460             


Leu Tyr  Ser Leu Asn Val Ser  Val Ser Asp Gly Leu  Phe Thr Ser 
    2465                 2470                 2475             


Thr Ala  Gln Val His Ile Arg  Val Leu Gly Ala Asn  Leu Tyr Ser 
    2480                 2485                 2490             


Pro Ala  Phe Ser Gln Ser Thr  Tyr Val Ala Glu Val  Arg Glu Asn 
    2495                 2500                 2505             


Val Ala  Ala Gly Thr Lys Val  Ile His Val Arg Ala  Thr Asp Gly 
    2510                 2515                 2520             


Asp Pro  Gly Thr Tyr Gly Gln  Ile Ser Tyr Ala Ile  Ile Asn Asp 
    2525                 2530                 2535             


Phe Ala  Lys Asp Arg Phe Leu  Ile Asp Ser Asn Gly  Gln Val Ile 
    2540                 2545                 2550             


Thr Thr  Glu Arg Leu Asp Arg  Glu Asn Pro Leu Glu  Gly Asp Val 
    2555                 2560                 2565             


Ser Ile  Phe Val Arg Ala Leu  Asp Gly Gly Gly Arg  Thr Thr Phe 
    2570                 2575                 2580             


Cys Thr  Val Arg Val Ile Val  Val Asp Glu Asn Asp  Asn Ala Pro 
    2585                 2590                 2595             


Gln Phe  Met Thr Val Glu Tyr  Arg Ala Ser Val Arg  Ala Asp Val 
    2600                 2605                 2610             


Gly Arg  Gly His Leu Val Thr  Gln Val Gln Ala Ile  Asp Pro Asp 
    2615                 2620                 2625             


Asp Gly  Ala Asn Ser Arg Ile  Thr Tyr Ser Leu Tyr  Ser Glu Ala 
    2630                 2635                 2640             


Ser Val  Ser Val Ala Asp Leu  Leu Glu Ile Asp Pro  Asp Asn Gly 
    2645                 2650                 2655             


Trp Met  Val Thr Lys Gly Asn  Phe Asn Gln Leu Lys  Asn Thr Val 
    2660                 2665                 2670             


Leu Ser  Phe Phe Val Lys Ala  Val Asp Gly Gly Ile  Pro Val Lys 
    2675                 2680                 2685             


His Ser  Leu Ile Pro Val Tyr  Ile His Val Leu Pro  Pro Glu Thr 
    2690                 2695                 2700             


Phe Leu  Pro Ser Phe Thr Gln  Ser Gln Tyr Ser Phe  Thr Ile Ala 
    2705                 2710                 2715             


Glu Asp  Thr Ala Ile Gly Ser  Thr Val Asp Thr Leu  Arg Ile Leu 
    2720                 2725                 2730             


Pro Ser  Gln Asn Val Trp Phe  Ser Thr Val Asn Gly  Glu Arg Pro 
    2735                 2740                 2745             


Glu Asn  Asn Lys Gly Gly Ile  Phe Val Ile Glu Gln  Glu Thr Gly 
    2750                 2755                 2760             


Thr Ile  Lys Leu Asp Lys Arg  Leu Asp Arg Glu Thr  Ser Pro Ala 
    2765                 2770                 2775             


Phe His  Phe Lys Val Ala Ala  Thr Ile Pro Leu Asp  Lys Val Asp 
    2780                 2785                 2790             


Ile Val  Phe Thr Val Asp Val  Asp Ile Lys Val Leu  Asp Leu Asn 
    2795                 2800                 2805             


Asp Asn  Lys Pro Val Phe Glu  Thr Ser Ser Tyr Asp  Thr Ile Ile 
    2810                 2815                 2820             


Met Glu  Gly Met Pro Val Gly  Thr Lys Leu Thr Gln  Val Arg Ala 
    2825                 2830                 2835             


Ile Asp  Met Asp Trp Gly Ala  Asn Gly Gln Val Thr  Tyr Ser Leu 
    2840                 2845                 2850             


His Ser  Asp Ser Gln Pro Glu  Lys Val Met Glu Ala  Phe Asn Ile 
    2855                 2860                 2865             


Asp Ser  Asn Thr Gly Trp Ile  Ser Thr Leu Lys Asp  Leu Asp His 
    2870                 2875                 2880             


Glu Thr  Asp Pro Thr Phe Thr  Phe Ser Val Val Ala  Ser Asp Leu 
    2885                 2890                 2895             


Gly Glu  Ala Phe Ser Leu Ser  Ser Thr Ala Leu Val  Ser Val Arg 
    2900                 2905                 2910             


Val Thr  Asp Ile Asn Asp Asn  Ala Pro Val Phe Ala  Gln Glu Val 
    2915                 2920                 2925             


Tyr Arg  Gly Asn Val Lys Glu  Ser Asp Pro Pro Gly  Glu Val Val 
    2930                 2935                 2940             


Ala Val  Leu Ser Thr Trp Asp  Arg Asp Thr Ser Asp  Val Asn Arg 
    2945                 2950                 2955             


Gln Val  Ser Tyr His Ile Thr  Gly Gly Asn Pro Arg  Gly Arg Phe 
    2960                 2965                 2970             


Ala Leu  Gly Leu Val Gln Ser  Glu Trp Lys Val Tyr  Val Lys Arg 
    2975                 2980                 2985             


Pro Leu  Asp Arg Glu Glu Gln  Asp Ile Tyr Phe Leu  Asn Ile Thr 
    2990                 2995                 3000             


Ala Thr  Asp Gly Leu Phe Val  Thr Gln Ala Met Val  Glu Val Ser 
    3005                 3010                 3015             


Val Ser  Asp Val Asn Asp Asn  Ser Pro Val Cys Asp  Gln Val Ala 
    3020                 3025                 3030             


Tyr Thr  Ala Leu Leu Pro Glu  Asp Ile Pro Ser Asn  Lys Ile Ile 
    3035                 3040                 3045             


Leu Lys  Val Ser Ala Lys Asp  Ala Asp Ile Gly Ser  Asn Gly Tyr 
    3050                 3055                 3060             


Ile Arg  Tyr Ser Leu Tyr Gly  Ser Gly Asn Ser Glu  Phe Phe Leu 
    3065                 3070                 3075             


Asp Pro  Glu Ser Gly Glu Leu  Lys Thr Leu Ala Leu  Leu Asp Arg 
    3080                 3085                 3090             


Glu Arg  Ile Pro Val Tyr Ser  Leu Met Ala Lys Ala  Thr Asp Gly 
    3095                 3100                 3105             


Gly Gly  Arg Phe Cys Gln Ser  Asn Ile His Leu Ile  Leu Glu Asp 
    3110                 3115                 3120             


Val Asn  Asp Asn Pro Pro Val  Phe Ser Ser Asp His  Tyr Asn Thr 
    3125                 3130                 3135             


Cys Val  Tyr Glu Asn Thr Ala  Thr Lys Ala Leu Leu  Thr Arg Val 
    3140                 3145                 3150             


Gln Ala  Val Asp Pro Asp Ile  Gly Ile Asn Arg Lys  Val Val Tyr 
    3155                 3160                 3165             


Ser Leu  Ala Asp Ser Ala Gly  Gly Val Phe Ser Ile  Asp Ser Ser 
    3170                 3175                 3180             


Ser Gly  Ile Ile Ile Leu Glu  Gln Pro Leu Asp Arg  Glu Gln Gln 
    3185                 3190                 3195             


Ser Ser  Tyr Asn Ile Ser Val  Arg Ala Thr Asp Gln  Ser Pro Gly 
    3200                 3205                 3210             


Gln Ser  Leu Ser Ser Leu Thr  Thr Val Thr Ile Thr  Val Leu Asp 
    3215                 3220                 3225             


Ile Asn  Asp Asn Pro Pro Val  Phe Glu Arg Arg Asp  Tyr Leu Val 
    3230                 3235                 3240             


Thr Val  Pro Glu Asp Thr Ser  Pro Gly Thr Gln Val  Leu Ala Val 
    3245                 3250                 3255             


Phe Ala  Thr Ser Lys Asp Ile  Gly Thr Asn Ala Glu  Ile Thr Tyr 
    3260                 3265                 3270             


Leu Ile  Arg Ser Gly Asn Glu  Gln Gly Lys Phe Lys  Ile Asn Pro 
    3275                 3280                 3285             


Lys Thr  Gly Gly Ile Ser Val  Ser Glu Val Leu Asp  Tyr Glu Leu 
    3290                 3295                 3300             


Cys Lys  Arg Phe Tyr Leu Val  Val Glu Ala Lys Asp  Gly Gly Thr 
    3305                 3310                 3315             


Pro Ala  Leu Ser Ala Val Ala  Thr Val Asn Ile Asn  Leu Thr Asp 
    3320                 3325                 3330             


Val Asn  Asp Asn Pro Pro Lys  Phe Ser Gln Asp Val  Tyr Ser Ala 
    3335                 3340                 3345             


Val Ile  Ser Glu Asp Ala Leu  Val Gly Asp Ser Val  Ile Leu Leu 
    3350                 3355                 3360             


Ile Ala  Glu Asp Val Asp Ser  Gln Pro Asn Gly Gln  Ile His Phe 
    3365                 3370                 3375             


Ser Ile  Val Asn Gly Asp Arg  Asp Asn Glu Phe Thr  Val Asp Pro 
    3380                 3385                 3390             


Val Leu  Gly Leu Val Lys Val  Lys Lys Lys Leu Asp  Arg Glu Arg 
    3395                 3400                 3405             


Val Ser  Gly Tyr Ser Leu Leu  Val Gln Ala Val Asp  Ser Gly Ile 
    3410                 3415                 3420             


Pro Ala  Met Ser Ser Thr Ala  Thr Val Asn Ile Asp  Ile Ser Asp 
    3425                 3430                 3435             


Val Asn  Asp Asn Ser Pro Val  Phe Thr Pro Ala Asn  Tyr Thr Ala 
    3440                 3445                 3450             


Val Ile  Gln Glu Asn Lys Pro  Val Gly Thr Ser Ile  Leu Gln Leu 
    3455                 3460                 3465             


Val Val  Thr Asp Arg Asp Ser  Phe His Asn Gly Pro  Pro Phe Ser 
    3470                 3475                 3480             


Phe Ser  Ile Leu Ser Gly Asn  Glu Glu Glu Glu Phe  Val Leu Asp 
    3485                 3490                 3495             


Pro His  Gly Ile Leu Arg Ser  Ala Val Val Phe Gln  His Thr Glu 
    3500                 3505                 3510             


Ser Leu  Glu Tyr Val Leu Cys  Val Gln Ala Lys Asp  Ser Gly Lys 
    3515                 3520                 3525             


Pro Gln  Gln Val Ser His Thr  Tyr Ile Arg Val Arg  Val Ile Glu 
    3530                 3535                 3540             


Glu Ser  Thr His Lys Pro Thr  Ala Ile Pro Leu Glu  Ile Phe Ile 
    3545                 3550                 3555             


Val Thr  Met Glu Asp Asp Phe  Pro Gly Gly Val Ile  Gly Lys Ile 
    3560                 3565                 3570             


His Ala  Thr Asp Gln Asp Met  Tyr Asp Val Leu Thr  Phe Ala Leu 
    3575                 3580                 3585             


Lys Ser  Glu Gln Lys Ser Leu  Phe Lys Val Asn Ser  His Asp Gly 
    3590                 3595                 3600             


Lys Ile  Ile Ala Leu Gly Gly  Leu Asp Ser Gly Lys  Tyr Val Leu 
    3605                 3610                 3615             


Asn Val  Ser Val Ser Asp Gly  Arg Phe Gln Val Pro  Ile Asp Val 
    3620                 3625                 3630             


Val Val  His Val Glu Gln Leu  Val His Glu Met Leu  Gln Asn Thr 
    3635                 3640                 3645             


Val Thr  Ile Arg Phe Glu Asn  Val Ser Pro Glu Asp  Phe Val Gly 
    3650                 3655                 3660             


Leu His  Met His Gly Phe Arg  Arg Thr Leu Arg Asn  Ala Val Leu 
    3665                 3670                 3675             


Thr Gln  Lys Gln Asp Ser Leu  Arg Ile Ile Ser Ile  Gln Pro Val 
    3680                 3685                 3690             


Ala Gly  Thr Asn Gln Leu Asp  Met Leu Phe Ala Val  Glu Met His 
    3695                 3700                 3705             


Ser Ser  Glu Phe Tyr Lys Pro  Ala Tyr Leu Ile Gln  Lys Leu Ser 
    3710                 3715                 3720             


Asn Ala  Arg Arg His Leu Glu  Asn Ile Met Arg Ile  Ser Ala Ile 
    3725                 3730                 3735             


Leu Glu  Lys Asn Cys Ser Gly  Leu Asp Cys Gln Glu  Gln His Cys 
    3740                 3745                 3750             


Glu Gln  Gly Leu Ser Leu Asp  Ser His Ala Leu Met  Thr Tyr Ser 
    3755                 3760                 3765             


Thr Ala  Arg Ile Ser Phe Val  Cys Pro Arg Phe Tyr  Arg Asn Val 
    3770                 3775                 3780             


Arg Cys  Thr Cys Asn Gly Gly  Leu Cys Pro Gly Ser  Asn Asp Pro 
    3785                 3790                 3795             


Cys Val  Glu Lys Pro Cys Pro  Gly Asp Met Gln Cys  Val Ser Tyr 
    3800                 3805                 3810             


Glu Ala  Ser Arg Arg Pro Phe  Leu Cys Gln Cys Pro  Pro Gly Lys 
    3815                 3820                 3825             


Leu Gly  Glu Cys Ser Gly His  Thr Ser Leu Ser Phe  Ala Gly Asn 
    3830                 3835                 3840             


Ser Tyr  Ile Lys Tyr Arg Leu  Ser Glu Asn Ser Lys  Glu Glu Asp 
    3845                 3850                 3855             


Phe Lys  Leu Ala Leu Arg Leu  Arg Thr Leu Gln Ser  Asn Gly Ile 
    3860                 3865                 3870             


Ile Met  Tyr Thr Arg Ala Asn  Pro Cys Ile Ile Leu  Lys Ile Val 
    3875                 3880                 3885             


Asp Gly  Lys Leu Trp Phe Gln  Leu Asp Cys Gly Ser  Gly Pro Gly 
    3890                 3895                 3900             


Ile Leu  Gly Ile Ser Gly Arg  Ala Val Asn Asp Gly  Ser Trp His 
    3905                 3910                 3915             


Ser Val  Phe Leu Glu Leu Asn  Arg Asn Phe Thr Ser  Leu Ser Leu 
    3920                 3925                 3930             


Asp Asp  Ser Tyr Val Glu Arg  Arg Arg Ala Pro Leu  Tyr Phe Gln 
    3935                 3940                 3945             


Thr Leu  Ser Thr Glu Ser Ser  Ile Tyr Phe Gly Ala  Leu Val Gln 
    3950                 3955                 3960             


Ala Asp  Asn Ile Arg Ser Leu  Thr Asp Thr Arg Val  Thr Gln Val 
    3965                 3970                 3975             


Leu Ser  Gly Phe Gln Gly Cys  Leu Asp Ser Val Ile  Leu Asn Asn 
    3980                 3985                 3990             


Asn Glu  Leu Pro Leu Gln Asn  Lys Arg Ser Ser Phe  Ala Glu Val 
    3995                 4000                 4005             


Val Gly  Leu Thr Glu Leu Lys  Leu Gly Cys Val Leu  Tyr Pro Asp 
    4010                 4015                 4020             


Ala Cys  Lys Arg Ser Pro Cys  Gln His Gly Gly Ser  Cys Thr Gly 
    4025                 4030                 4035             


Leu Pro  Ser Gly Gly Tyr Gln  Cys Thr Cys Leu Ser  Gln Phe Thr 
    4040                 4045                 4050             


Gly Arg  Asn Cys Glu Ser Glu  Ile Thr Ala Cys Phe  Pro Asn Pro 
    4055                 4060                 4065             


Cys Arg  Asn Gly Gly Ser Cys  Asp Pro Ile Gly Asn  Thr Phe Ile 
    4070                 4075                 4080             


Cys Asn  Cys Lys Ala Gly Leu  Thr Gly Val Thr Cys  Glu Glu Asp 
    4085                 4090                 4095             


Ile Asn  Glu Cys Glu Arg Glu  Glu Cys Glu Asn Gly  Gly Ser Cys 
    4100                 4105                 4110             


Val Asn  Val Phe Gly Ser Phe  Leu Cys Asn Cys Thr  Pro Gly Tyr 
    4115                 4120                 4125             


Val Gly  Gln Tyr Cys Gly Leu  Arg Pro Val Val Val  Pro Asn Ile 
    4130                 4135                 4140             


Gln Ala  Gly His Ser Tyr Val  Gly Lys Glu Glu Leu  Ile Gly Ile 
    4145                 4150                 4155             


Ala Val  Val Leu Phe Val Ile  Phe Ile Leu Val Val  Leu Phe Ile 
    4160                 4165                 4170             


Val Phe  Arg Lys Lys Val Phe  Arg Lys Asn Tyr Ser  Arg Asn Asn 
    4175                 4180                 4185             


Ile Thr  Leu Val Gln Asp Pro  Ala Thr Ala Ala Leu  Leu Asn Lys 
    4190                 4195                 4200             


Ser Asn  Gly Ile Pro Phe Arg  Asn Leu Arg Gly Ser  Gly Asp Gly 
    4205                 4210                 4215             


Arg Asn  Val Tyr Gln Glu Val  Gly Pro Pro Gln Val  Pro Val Arg 
    4220                 4225                 4230             


Pro Met  Ala Tyr Thr Pro Cys  Phe Gln Ser Asp Ser  Arg Ser Asn 
    4235                 4240                 4245             


Leu Asp  Lys Ile Val Asp Gly  Leu Gly Gly Glu His  Gln Glu Met 
    4250                 4255                 4260             


Thr Thr  Phe His Pro Glu Ser  Pro Arg Ile Leu Thr  Ala Arg Arg 
    4265                 4270                 4275             


Gly Val  Val Val Cys Ser Val  Ala Pro Asn Leu Pro  Ala Val Ser 
    4280                 4285                 4290             


Pro Cys  Arg Ser Asp Cys Asp  Ser Ile Arg Lys Asn  Gly Trp Asp 
    4295                 4300                 4305             


Ala Gly  Thr Glu Asn Lys Gly  Val Asp Asp Pro Gly  Glu Val Thr 
    4310                 4315                 4320             


Cys Phe  Ala Gly Ser Asn Lys  Gly Ser Asn Ser Glu  Val Gln Ser 
    4325                 4330                 4335             


Leu Ser  Ser Phe Gln Ser Asp  Ser Gly Asp Asp Asn  Ala Tyr His 
    4340                 4345                 4350             


Trp Asp  Thr Ser Asp Trp Met  Pro Gly Ala Arg Leu  Ser Asp Ile 
    4355                 4360                 4365             


Glu Glu  Val Pro Asn Tyr Glu  Asn Gln Asp Gly Gly  Ser Ala His 
    4370                 4375                 4380             


Gln Gly  Ser Thr Arg Glu Leu  Glu Ser Asp Tyr Tyr  Leu Gly Gly 
    4385                 4390                 4395             


Tyr Asp  Ile Asp Ser Glu Tyr  Pro Pro Pro His Glu  Glu Glu Phe 
    4400                 4405                 4410             


Leu Ser  Gln Asp Gln Leu Pro  Pro Pro Leu Pro Glu  Asp Phe Pro 
    4415                 4420                 4425             


Asp Gln  Tyr Glu Ala Leu Pro  Pro Ser Gln Pro Val  Ser Leu Ala 
    4430                 4435                 4440             


Ser Thr  Leu Ser Pro Asp Cys  Arg Arg Arg Pro Gln  Phe His Pro 
    4445                 4450                 4455             


Ser Gln  Tyr Leu Pro Pro His  Pro Phe Pro Asn Glu  Thr Asp Leu 
    4460                 4465                 4470             


Val Gly  Pro Pro Ala Ser Cys  Glu Phe Ser Thr Phe  Ala Val Ser 
    4475                 4480                 4485             


Met Asn  Gln Gly Thr Glu Pro  Thr Gly Pro Ala Asp  Ser Val Ser 
    4490                 4495                 4500             


Leu Ser  Leu His Asn Ser Arg  Gly Thr Ser Ser Ser  Asp Val Ser 
    4505                 4510                 4515             


Ala Asn  Cys Gly Phe Asp Asp  Ser Glu Val Ala Met  Ser Asp Tyr 
    4520                 4525                 4530             


Glu Ser  Val Gly Glu Leu Ser  Leu Ala Ser Leu His  Ile Pro Phe 
    4535                 4540                 4545             


Val Glu  Thr Gln His Gln Thr  Gln Val 
    4550                 4555         


<210>  554
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  554

Met Arg Gln Leu Cys Arg Gly Arg Val Leu Gly Ile Ser Val Ala Ile 
1               5                   10                  15      


Ala His Gly Val Phe Ser Gly Ser Leu Asn Ile Leu Leu Lys Phe Leu 
            20                  25                  30          


Ile Ser Arg Tyr Gln Phe Ser Phe Leu Thr Leu Val Gln Cys Leu Thr 
        35                  40                  45              


Ser Ser Thr Ala Ala Leu Ser Leu Glu Leu Leu Arg Arg Leu Gly Leu 
    50                  55                  60                  


Ile Ala Val Pro Pro Phe Gly Leu Ser Leu Ala Arg Ser Phe Ala Gly 
65                  70                  75                  80  


Val Ala Val Leu Ser Thr Leu Gln Ser Ser Leu Thr Leu Trp Ser Leu 
                85                  90                  95      


Arg Gly Leu Ser Leu Pro Met Tyr Val Val Phe Lys Arg Cys Leu Pro 
            100                 105                 110         


Leu Val Thr Met Leu Ile Gly Val Leu Val Leu Lys Asn Gly Ala Pro 
        115                 120                 125             


Ser Pro Gly Val Leu Ala Ala Val Leu Ile Thr Thr Cys Gly Ala Ala 
    130                 135                 140                 


Leu Ala Gly Ala Gly Asp Leu Thr Gly Asp Pro Ile Gly Tyr Val Thr 
145                 150                 155                 160 


Gly Val Leu Ala Val Leu Val His Ala Ala Tyr Leu Val Leu Ile Gln 
                165                 170                 175     


Lys Ala Ser Ala Asp Thr Glu His Gly Pro Leu Thr Ala Gln Tyr Val 
            180                 185                 190         


Ile Ala Val Ser Ala Thr Pro Leu Leu Val Ile Cys Ser Phe Ala Ser 
        195                 200                 205             


Thr Asp Ser Ile His Ala Trp Thr Phe Pro Gly Trp Lys Asp Pro Ala 
    210                 215                 220                 


Met Val Cys Ile Phe Val Ala Cys Ile Leu Ile Gly Cys Ala Met Asn 
225                 230                 235                 240 


Phe Thr Thr Leu His Cys Thr Tyr Ile Asn Ser Ala Val Thr Thr Ser 
                245                 250                 255     


Phe Val Gly Val Val Lys Ser Ile Ala Thr Ile Thr Val Gly Met Val 
            260                 265                 270         


Ala Phe Ser Asp Val Glu Pro Thr Ser Leu Phe Ile Ala Gly Val Val 
        275                 280                 285             


Val Asn Thr Leu Gly Ser Ile Ile Tyr Cys Val Ala Lys Phe Met Glu 
    290                 295                 300                 


Thr Arg Lys Gln Ser Asn Tyr Glu Asp Leu Glu Ala Gln Pro Arg Gly 
305                 310                 315                 320 


Glu Glu Ala Gln Leu Ser Gly Asp Gln Leu Pro Phe Val Met Glu Glu 
                325                 330                 335     


Leu Pro Gly Glu Gly Gly Asn Gly Arg Ser Glu Gly Gly Glu Ala Ala 
            340                 345                 350         


Gly Gly Pro Ala Gln Glu Ser Arg Gln Glu Val Arg Gly Ser Pro Arg 
        355                 360                 365             


Gly Val Pro Leu Val Ala Gly Ser Ser Glu Glu Gly Ser Arg Arg Ser 
    370                 375                 380                 


Leu Lys Asp Ala Tyr Leu Glu Val Trp Arg Leu Val Arg Gly Thr Arg 
385                 390                 395                 400 


Tyr Met Lys Lys Asp Tyr Leu Ile Glu Asn Glu Glu Leu Pro Ser Pro 
                405                 410                 415     


<210>  555
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  555

Met Ser Gln Gly Arg Gly Lys Tyr Asp Phe Tyr Ile Gly Leu Gly Leu 
1               5                   10                  15      


Ala Met Ser Ser Ser Ile Phe Ile Gly Gly Ser Phe Ile Leu Lys Lys 
            20                  25                  30          


Lys Gly Leu Leu Arg Leu Ala Arg Lys Gly Ser Met Arg Ala Gly Gln 
        35                  40                  45              


Gly Gly His Ala Tyr Leu Lys Glu Trp Leu Trp Trp Ala Gly Leu Leu 
    50                  55                  60                  


Ser Met Gly Ala Gly Glu Val Ala Asn Phe Ala Ala Tyr Ala Phe Ala 
65                  70                  75                  80  


Pro Ala Thr Leu Val Thr Pro Leu Gly Ala Leu Ser Val Leu Val Ser 
                85                  90                  95      


Ala Ile Leu Ser Ser Tyr Phe Leu Asn Glu Arg Leu Asn Leu His Gly 
            100                 105                 110         


Lys Ile Gly Cys Leu Leu Ser Ile Leu Gly Ser Thr Val Met Val Ile 
        115                 120                 125             


His Ala Pro Lys Glu Glu Glu Ile Glu Thr Leu Asn Glu Met Ser His 
    130                 135                 140                 


Lys Leu Gly Asp Pro Gly Phe Val Val Phe Ala Thr Leu Val Val Ile 
145                 150                 155                 160 


Val Ala Leu Ile Leu Ile Phe Val Val Gly Pro Arg His Gly Gln Thr 
                165                 170                 175     


Asn Ile Leu Val Tyr Ile Thr Ile Cys Ser Val Ile Gly Ala Phe Ser 
            180                 185                 190         


Val Ser Cys Val Lys Gly Leu Gly Ile Ala Ile Lys Glu Leu Phe Ala 
        195                 200                 205             


Gly Lys Pro Val Leu Arg His Pro Leu Ala Trp Ile Leu Leu Leu Ser 
    210                 215                 220                 


Leu Ile Val Cys Val Ser Thr Gln Ile Asn Tyr Leu Asn Arg Ala Leu 
225                 230                 235                 240 


Asp Ile Phe Asn Thr Ser Ile Val Thr Pro Ile Tyr Tyr Val Phe Phe 
                245                 250                 255     


Thr Thr Ser Val Leu Thr Cys Ser Ala Ile Leu Phe Lys Glu Trp Gln 
            260                 265                 270         


Asp Met Pro Val Asp Asp Val Ile Gly Thr Leu Ser Gly Phe Phe Thr 
        275                 280                 285             


Ile Ile Val Gly Ile Phe Leu Leu His Ala Phe Lys Asp Val Ser Phe 
    290                 295                 300                 


Ser Leu Ala Ser Leu Pro Val Ser Phe Arg Lys Asp Glu Lys Ala Met 
305                 310                 315                 320 


Asn Gly Asn Leu Ser Asn Met Tyr Glu Val Leu Asn Asn Asn Glu Glu 
                325                 330                 335     


Ser Leu Thr Cys Gly Ile Glu Gln His Thr Gly Glu Asn Val Ser Arg 
            340                 345                 350         


Arg Asn Gly Asn Leu Thr Ala Phe 
        355                 360 


<210>  556
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  556

Met Ser Gln Gly Arg Gly Lys Tyr Asp Phe Tyr Ile Gly Leu Gly Leu 
1               5                   10                  15      


Ala Met Ser Ser Ser Ile Phe Ile Gly Gly Ser Phe Ile Leu Lys Lys 
            20                  25                  30          


Lys Gly Leu Leu Arg Leu Ala Arg Lys Gly Ser Met Arg Ala Gly Gln 
        35                  40                  45              


Gly Gly His Ala Tyr Leu Lys Glu Trp Leu Trp Trp Ala Gly Leu Leu 
    50                  55                  60                  


Ser Met Gly Ala Gly Glu Val Ala Asn Phe Ala Ala Tyr Ala Phe Ala 
65                  70                  75                  80  


Pro Ala Thr Leu Val Thr Pro Leu Gly Ala Leu Ser Val Leu Val Ser 
                85                  90                  95      


Ala Ile Leu Ser Ser Tyr Phe Leu Asn Glu Arg Leu Asn Leu His Gly 
            100                 105                 110         


Lys Ile Gly Cys Leu Leu Ser Ile Leu Gly Ser Thr Val Met Val Ile 
        115                 120                 125             


His Ala Pro Lys Glu Glu Glu Ile Glu Thr Leu Asn Glu Met Ser His 
    130                 135                 140                 


Lys Leu Gly Asp Pro Gly Phe Val Val Phe Ala Thr Leu Val Val Ile 
145                 150                 155                 160 


Val Ala Leu Ile Leu Ile Phe Val Val Gly Pro Arg His Gly Gln Thr 
                165                 170                 175     


Asn Ile Leu Val Tyr Ile Thr Ile Cys Ser Val Ile Gly Ala Phe Ser 
            180                 185                 190         


Val Ser Cys Val Lys Gly Leu Gly Ile Ala Ile Lys Glu Leu Phe Ala 
        195                 200                 205             


Gly Lys Pro Val Leu Arg His Pro Leu Ala Trp Ile Leu Leu Leu Ser 
    210                 215                 220                 


Leu Ile Val Cys Val Ser Thr Gln Ile Asn Tyr Leu Asn Arg Ala Leu 
225                 230                 235                 240 


Asp Ile Phe Asn Thr Ser Ile Val Thr Pro Ile Tyr Tyr Val Phe Phe 
                245                 250                 255     


Thr Thr Ser Val Leu Thr Cys Ser Ala Ile Leu Phe Lys Glu Trp Gln 
            260                 265                 270         


Asp Met Pro Val Asp Asp Val Ile Gly Thr Leu Ser Gly Phe Phe Thr 
        275                 280                 285             


Ile Ile Val Gly Ile Phe Leu Leu His Ala Phe Lys Asp Val Ser Phe 
    290                 295                 300                 


Ser Leu Ala Ser Leu Pro Val Ser Phe Arg Lys Asp Glu Lys Ala Met 
305                 310                 315                 320 


Asn Gly Asn Leu Ser Asn Met Tyr Glu Val Leu Asn Asn Asn Glu Glu 
                325                 330                 335     


Ser Leu Thr Cys Gly Ile Glu Gln His Thr Gly Glu Asn Val Ser Arg 
            340                 345                 350         


Arg Asn Gly Asn Leu Thr Ala Phe 
        355                 360 


<210>  557
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  557

Met Ser Gln Gly Arg Gly Lys Tyr Asp Phe Tyr Ile Gly Leu Gly Leu 
1               5                   10                  15      


Ala Met Ser Ser Ser Ile Phe Ile Gly Gly Ser Phe Ile Leu Lys Lys 
            20                  25                  30          


Lys Gly Leu Leu Arg Leu Ala Arg Lys Gly Ser Met Arg Ala Val Gly 
        35                  40                  45              


Ala Gly Glu Val Ala Asn Phe Ala Ala Tyr Ala Phe Ala Pro Ala Thr 
    50                  55                  60                  


Leu Val Thr Pro Leu Gly Ala Leu Ser Val Leu Val Ser Ala Ile Leu 
65                  70                  75                  80  


Ser Ser Tyr Phe Leu Asn Glu Arg Leu Asn Leu His Gly Lys Ile Gly 
                85                  90                  95      


Cys Leu Leu Ser Ile Leu Gly Ser Thr Val Met Val Ile His Ala Pro 
            100                 105                 110         


Lys Glu Glu Glu Ile Glu Thr Leu Asn Glu Met Ser His Lys Leu Gly 
        115                 120                 125             


Asp Pro Gly Phe Val Val Phe Ala Thr Leu Val Val Ile Val Ala Leu 
    130                 135                 140                 


Ile Leu Ile Phe Val Val Gly Pro Arg His Gly Gln Thr Asn Ile Leu 
145                 150                 155                 160 


Val Tyr Ile Thr Ile Cys Ser Val Ile Gly Ala Phe Ser Val Ser Cys 
                165                 170                 175     


Val Lys Gly Leu Gly Ile Ala Ile Lys Glu Leu Phe Ala Gly Lys Pro 
            180                 185                 190         


Val Leu Arg His Pro Leu Ala Trp Ile Leu Leu Leu Ser Leu Ile Val 
        195                 200                 205             


Cys Val Ser Thr Gln Ile Asn Tyr Leu Asn Arg Ala Leu Asp Ile Phe 
    210                 215                 220                 


Asn Thr Ser Ile Val Thr Pro Ile Tyr Tyr Val Phe Phe Thr Thr Ser 
225                 230                 235                 240 


Val Leu Thr Cys Ser Ala Ile Leu Phe Lys Glu Trp Gln Asp Met Pro 
                245                 250                 255     


Val Asp Asp Val Ile Gly Thr Leu Ser Gly Phe Phe Thr Ile Ile Val 
            260                 265                 270         


Gly Ile Phe Leu Leu His Ala Phe Lys Asp Val Ser Phe Ser Leu Ala 
        275                 280                 285             


Ser Leu Pro Val Ser Phe Arg Lys Asp Glu Lys Ala Met Asn Gly Asn 
    290                 295                 300                 


Leu Ser Asn Met Tyr Glu Val Leu Asn Asn Asn Glu Glu Ser Leu Thr 
305                 310                 315                 320 


Cys Gly Ile Glu Gln His Thr Gly Glu Asn Val Ser Arg Arg Asn Gly 
                325                 330                 335     


Asn Leu Thr Ala Phe 
            340     


<210>  558
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  558

Met Asn Val Asp Ala Glu Ala Ser Met Ala Val Ile Ser Leu Leu Phe 
1               5                   10                  15      


Leu Ala Val Met Tyr Val Val His His Pro Leu Met Val Ser Asp Arg 
            20                  25                  30          


Met Asp Leu Asp Thr Leu Ala Arg Ser Arg Gln Leu Glu Lys Arg Met 
        35                  40                  45              


Ser Glu Glu Met Arg Leu Leu Glu Met Glu Phe Glu Glu Arg Lys Arg 
    50                  55                  60                  


Ala Ala Glu Gln Arg Gln Lys Ala Glu Asn Phe Trp Thr Gly Asp Thr 
65                  70                  75                  80  


Ser Ser Asp Gln Leu Val Leu Gly Lys Lys Asp Met Gly Trp Pro Phe 
                85                  90                  95      


Gln Ala Asp Gly Gln Glu Gly Pro Leu Gly Trp Met Leu Gly Asn Leu 
            100                 105                 110         


Trp Asn Thr Gly Leu Phe Cys Leu Phe Leu Val Phe Glu Leu Leu Arg 
        115                 120                 125             


Gln Asn Met Gln His Glu Pro Ala Phe Asp Ser Ser Ser Glu Glu Glu 
    130                 135                 140                 


Glu Glu Glu Val Arg Val Val Pro Val Thr Ser Tyr Asn Trp Leu Thr 
145                 150                 155                 160 


Asp Phe Pro Ser Gln Glu Ala Leu Asp Ser Phe Tyr Lys His Tyr Val 
                165                 170                 175     


Gln Asn Ala Ile Arg Asp Leu Pro Cys Thr Cys Glu Phe Val Glu Ser 
            180                 185                 190         


Phe Val Asp Asp Leu Ile Glu Ala Cys Arg Val Leu Ser Arg Gln Glu 
        195                 200                 205             


Ala His Pro Gln Leu Glu Asp Cys Leu Gly Ile Gly Ala Ala Phe Glu 
    210                 215                 220                 


Lys Trp Gly Thr Leu His Glu Thr Gln Lys Phe Asp Ile Leu Val Pro 
225                 230                 235                 240 


Ile Val Pro Pro Gln Gly Thr Met Phe Val Leu Glu Met Arg Asp Pro 
                245                 250                 255     


Ala Leu Gly Arg Arg Cys Gly Cys Val Leu Val Glu Ser Glu Cys Val 
            260                 265                 270         


Cys Lys Arg Glu Lys Leu Leu Gly Asp Val Leu Cys Leu Val His His 
        275                 280                 285             


His Arg Asp Pro Ser Ala Val Leu Gly Lys Cys Ser Ser Ser Ile Lys 
    290                 295                 300                 


Ala Ala Leu Cys Thr Gly Phe His Leu Asp Val Cys Lys Thr Val Gln 
305                 310                 315                 320 


Trp Phe Arg Asn Met Met Gly Asn Ala Trp Ala Leu Val Ala His Lys 
                325                 330                 335     


Tyr Asp Phe Lys Leu Ser Leu Pro Pro Ser Thr Thr Ser Cys Lys Leu 
            340                 345                 350         


Arg Leu Asp Tyr Arg Ser Gly Arg Phe Leu Ser Ile His Leu Val Leu 
        355                 360                 365             


Gly Val Gln Arg Glu Asp Thr Leu Val Tyr Leu Val Ser Gln Ala Pro 
    370                 375                 380                 


Asp Gln Glu Gln Leu Thr Ser Val Asp Trp Pro Glu Ser Phe Val Ala 
385                 390                 395                 400 


Cys Glu His Leu Phe Leu Lys Leu Val Gly Arg Phe Ala Pro Glu Asn 
                405                 410                 415     


Thr Cys His Leu Lys Cys Leu Gln Ile Ile Leu Ser Leu Arg Gln His 
            420                 425                 430         


Gln Ser Leu Pro His Gly Ala Ser Arg Pro Ile Leu Thr Ser Tyr His 
        435                 440                 445             


Phe Lys Thr Ala Leu Met His Leu Leu Leu Arg Leu Pro Leu Thr Asp 
    450                 455                 460                 


Trp Ala His Asn Met Leu Ser Gln Arg Leu Gln Asp Ile Leu Trp Phe 
465                 470                 475                 480 


Leu Gly Arg Gly Leu Gln Gln Arg Ser Leu His His Phe Leu Ile Gly 
                485                 490                 495     


Asn Asn Phe Leu Pro Leu Thr Ile Pro Ile Pro Lys Thr Phe Arg Asn 
            500                 505                 510         


Ala Glu Pro Val Asn Leu Phe Gln His Leu Val Leu Asn Pro Lys Ala 
        515                 520                 525             


His Ser Gln Ala Val Glu Glu Phe Gln Asn Leu Leu Thr Gln Val Lys 
    530                 535                 540                 


Thr Leu Pro His Ala Pro Leu Ala Ala Ala Pro 
545                 550                 555 


<210>  559
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  559

Met Ser His Glu Lys Ser Phe Leu Val Ser Gly Asp Asn Tyr Pro Pro 
1               5                   10                  15      


Pro Asn Pro Gly Tyr Pro Gly Gly Pro Gln Pro Pro Met Pro Pro Tyr 
            20                  25                  30          


Ala Gln Pro Pro Tyr Pro Gly Ala Pro Tyr Pro Gln Pro Pro Phe Gln 
        35                  40                  45              


Pro Ser Pro Tyr Gly Gln Pro Gly Tyr Pro His Gly Pro Ser Pro Tyr 
    50                  55                  60                  


Pro Gln Gly Gly Tyr Pro Gln Gly Pro Tyr Pro Gln Gly Gly Tyr Pro 
65                  70                  75                  80  


Gln Gly Pro Tyr Pro Gln Glu Gly Tyr Pro Gln Gly Pro Tyr Pro Gln 
                85                  90                  95      


Gly Gly Tyr Pro Gln Gly Pro Tyr Pro Gln Ser Pro Phe Pro Pro Asn 
            100                 105                 110         


Pro Tyr Gly Gln Pro Gln Val Phe Pro Gly Gln Asp Pro Asp Ser Pro 
        115                 120                 125             


Gln His Gly Asn Tyr Gln Glu Glu Gly Pro Pro Ser Tyr Tyr Asp Asn 
    130                 135                 140                 


Gln Asp Phe Pro Ala Thr Asn Trp Asp Asp Lys Ser Ile Arg Gln Ala 
145                 150                 155                 160 


Phe Ile Arg Lys Val Phe Leu Val Leu Thr Leu Gln Leu Ser Val Thr 
                165                 170                 175     


Leu Ser Thr Val Ser Val Phe Thr Phe Val Ala Glu Val Lys Gly Phe 
            180                 185                 190         


Val Arg Glu Asn Val Trp Thr Tyr Tyr Val Ser Tyr Ala Val Phe Phe 
        195                 200                 205             


Ile Ser Leu Ile Val Leu Ser Cys Cys Gly Asp Phe Arg Arg Lys His 
    210                 215                 220                 


Pro Trp Asn Leu Val Ala Leu Ser Val Leu Thr Ala Ser Leu Ser Tyr 
225                 230                 235                 240 


Met Val Gly Met Ile Ala Ser Phe Tyr Asn Thr Glu Ala Val Ile Met 
                245                 250                 255     


Ala Val Gly Ile Thr Thr Ala Val Cys Phe Thr Val Val Ile Phe Ser 
            260                 265                 270         


Met Gln Thr Arg Tyr Asp Phe Thr Ser Cys Met Gly Val Leu Leu Val 
        275                 280                 285             


Ser Met Val Val Leu Phe Ile Phe Ala Ile Leu Cys Ile Phe Ile Arg 
    290                 295                 300                 


Asn Arg Ile Leu Glu Ile Val Tyr Ala Ser Leu Gly Ala Leu Leu Phe 
305                 310                 315                 320 


Thr Cys Phe Leu Ala Val Asp Thr Gln Leu Leu Leu Gly Asn Lys Gln 
                325                 330                 335     


Leu Ser Leu Ser Pro Glu Glu Tyr Val Phe Ala Ala Leu Asn Leu Tyr 
            340                 345                 350         


Thr Asp Ile Ile Asn Ile Phe Leu Tyr Ile Leu Thr Ile Ile Gly Arg 
        355                 360                 365             


Ala Lys Glu 
    370     


<210>  560
<211>  722
<212>  PRT
<213>  Homo sapiens

<400>  560

Met Leu Thr Phe Phe Leu Val Ser Gly Gly Ser Leu Trp Leu Phe Val 
1               5                   10                  15      


Glu Phe Val Leu Ser Leu Leu Glu Lys Met Gln Thr Gln Glu Ile Leu 
            20                  25                  30          


Arg Ile Leu Arg Leu Pro Glu Leu Gly Asp Leu Gly Gln Phe Phe Arg 
        35                  40                  45              


Ser Leu Ser Ala Thr Thr Leu Val Ser Met Gly Ala Leu Ala Ala Ile 
    50                  55                  60                  


Leu Ala Tyr Trp Phe Thr His Arg Pro Lys Ala Leu Gln Pro Pro Cys 
65                  70                  75                  80  


Asn Leu Leu Met Gln Ser Glu Glu Val Glu Asp Ser Gly Gly Ala Arg 
                85                  90                  95      


Arg Ser Val Ile Gly Ser Gly Pro Gln Leu Leu Thr His Tyr Tyr Asp 
            100                 105                 110         


Asp Ala Arg Thr Met Tyr Gln Val Phe Arg Arg Gly Leu Ser Ile Ser 
        115                 120                 125             


Gly Asn Gly Pro Cys Leu Gly Phe Arg Lys Pro Lys Gln Pro Tyr Gln 
    130                 135                 140                 


Trp Leu Ser Tyr Gln Glu Val Ala Asp Arg Ala Glu Phe Leu Gly Ser 
145                 150                 155                 160 


Gly Leu Leu Gln His Asn Cys Lys Ala Cys Thr Asp Gln Phe Ile Gly 
                165                 170                 175     


Val Phe Ala Gln Asn Arg Pro Glu Trp Ile Ile Val Glu Leu Ala Cys 
            180                 185                 190         


Tyr Thr Tyr Ser Met Val Val Val Pro Leu Tyr Asp Thr Leu Gly Pro 
        195                 200                 205             


Gly Ala Ile Arg Tyr Ile Ile Asn Thr Ala Asp Ile Ser Thr Val Ile 
    210                 215                 220                 


Val Asp Lys Pro Gln Lys Ala Val Leu Leu Leu Glu His Val Glu Arg 
225                 230                 235                 240 


Lys Glu Thr Pro Gly Leu Lys Leu Ile Ile Leu Met Asp Pro Phe Glu 
                245                 250                 255     


Glu Ala Leu Lys Glu Arg Gly Gln Lys Cys Gly Val Val Ile Lys Ser 
            260                 265                 270         


Met Gln Ala Val Glu Asp Cys Gly Gln Glu Asn His Gln Ala Pro Val 
        275                 280                 285             


Pro Pro Gln Pro Asp Asp Leu Ser Ile Val Cys Phe Thr Ser Gly Thr 
    290                 295                 300                 


Thr Gly Asn Pro Lys Gly Ala Met Leu Thr His Gly Asn Val Val Ala 
305                 310                 315                 320 


Asp Phe Ser Gly Phe Leu Lys Val Thr Glu Lys Val Ile Phe Pro Arg 
                325                 330                 335     


Gln Asp Asp Val Leu Ile Ser Phe Leu Pro Leu Ala His Met Phe Glu 
            340                 345                 350         


Arg Val Ile Gln Ser Val Val Tyr Cys His Gly Gly Arg Val Gly Phe 
        355                 360                 365             


Phe Gln Gly Asp Ile Arg Leu Leu Ser Asp Asp Met Lys Ala Leu Cys 
    370                 375                 380                 


Pro Thr Ile Phe Pro Val Val Pro Arg Leu Leu Asn Arg Met Tyr Asp 
385                 390                 395                 400 


Lys Ile Phe Ser Gln Ala Asn Thr Pro Leu Lys Arg Trp Leu Leu Glu 
                405                 410                 415     


Phe Ala Ala Lys Arg Lys Gln Ala Glu Val Arg Ser Gly Ile Ile Arg 
            420                 425                 430         


Asn Asp Ser Ile Trp Asp Glu Leu Phe Phe Asn Lys Ile Gln Ala Ser 
        435                 440                 445             


Leu Gly Gly Cys Val Arg Met Ile Val Thr Gly Ala Ala Pro Ala Ser 
    450                 455                 460                 


Pro Thr Val Leu Gly Phe Leu Arg Ala Ala Leu Gly Cys Gln Val Tyr 
465                 470                 475                 480 


Glu Gly Tyr Gly Gln Thr Glu Cys Thr Ala Gly Cys Thr Phe Thr Thr 
                485                 490                 495     


Pro Gly Asp Trp Thr Ser Gly His Val Gly Ala Pro Leu Pro Cys Asn 
            500                 505                 510         


His Ile Lys Leu Val Asp Val Glu Glu Leu Asn Tyr Trp Ala Cys Lys 
        515                 520                 525             


Gly Glu Gly Glu Ile Cys Val Arg Gly Pro Asn Val Phe Lys Gly Tyr 
    530                 535                 540                 


Leu Lys Asp Pro Asp Arg Thr Lys Glu Ala Leu Asp Ser Asp Gly Trp 
545                 550                 555                 560 


Leu His Thr Gly Asp Ile Gly Lys Trp Leu Pro Ala Gly Thr Leu Lys 
                565                 570                 575     


Ile Ile Asp Arg Lys Lys His Ile Phe Lys Leu Ala Gln Gly Glu Tyr 
            580                 585                 590         


Val Ala Pro Glu Lys Ile Glu Asn Ile Tyr Ile Arg Ser Gln Pro Val 
        595                 600                 605             


Ala Gln Ile Tyr Val His Gly Asp Ser Leu Lys Ala Phe Leu Val Gly 
    610                 615                 620                 


Ile Val Val Pro Asp Pro Glu Val Met Pro Ser Trp Ala Gln Lys Arg 
625                 630                 635                 640 


Gly Ile Glu Gly Thr Tyr Ala Asp Leu Cys Thr Asn Lys Asp Leu Lys 
                645                 650                 655     


Lys Ala Ile Leu Glu Asp Met Val Arg Leu Gly Lys Glu Ser Gly Leu 
            660                 665                 670         


His Ser Phe Glu Gln Val Lys Ala Ile His Ile His Ser Asp Met Phe 
        675                 680                 685             


Ser Val Gln Asn Gly Leu Leu Thr Pro Thr Leu Lys Ala Lys Arg Pro 
    690                 695                 700                 


Glu Leu Arg Glu Tyr Phe Lys Lys Gln Ile Glu Glu Leu Tyr Ser Ile 
705                 710                 715                 720 


Ser Met 
        


<210>  561
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  561

Met His Asp Ser Gly Leu Leu Asn Ile Thr Lys Val Ser Phe Ser Asp 
1               5                   10                  15      


Arg Gly Lys Tyr Thr Cys Val Ala Ser Asn Ile Tyr Gly Thr Val Asn 
            20                  25                  30          


Asn Thr Val Thr Leu Arg Val Ile Phe Thr Ser Gly Asp Met Gly Val 
        35                  40                  45              


Tyr Tyr Met Val Val Cys Leu Val Ala Phe Thr Ile Val Met Val Leu 
    50                  55                  60                  


Asn Ile Thr Arg Leu Cys Met Met Ser Ser His Leu Lys Lys Thr Glu 
65                  70                  75                  80  


Lys Ala Ile Asn Glu Phe Phe Arg Thr Glu Gly Ala Glu Lys Leu Gln 
                85                  90                  95      


Lys Ala Phe Glu Ile Ala Lys Arg Ile Pro Ile Ile Thr Ser Ala Lys 
            100                 105                 110         


Thr Leu Glu Leu Ala Lys Val Thr Gln Phe Lys Thr Met Glu Phe Ala 
        115                 120                 125             


Arg Tyr Ile Glu Glu Leu Ala Arg Ser Val Pro Leu Pro Pro Leu Ile 
    130                 135                 140                 


Met Asn Cys Arg Thr Ile Met Glu Glu Ile Met Glu Val Val Gly Leu 
145                 150                 155                 160 


Glu Glu Gln Gly Gln Asn Phe Val Arg His Thr Pro Glu Gly Gln Glu 
                165                 170                 175     


Ala Ala Asp Arg Asp Glu Val Tyr Thr Ile Pro Asn Ser Leu Lys Arg 
            180                 185                 190         


Ser Asp Ser Pro Ala Ala Asp Ser Asp Ala Ser Ser Leu His Glu Gln 
        195                 200                 205             


Pro Gln Gln Ile Ala Ile Lys Val Ser Val His Pro Gln Ser Lys Lys 
    210                 215                 220                 


Glu His Ala Asp Asp Gln Glu Gly Gly Gln Phe Glu Val Lys Asp Val 
225                 230                 235                 240 


Glu Glu Thr Glu Leu Ser Ala Glu His Ser Pro Glu Thr Ala Glu Pro 
                245                 250                 255     


Ser Thr Asp Val Thr Ser Thr Glu Leu Thr Ser Glu Glu Pro Thr Pro 
            260                 265                 270         


Val Glu Val Pro Asp Lys Val Leu Pro Pro Ala Tyr Leu Glu Ala Thr 
        275                 280                 285             


Glu Pro Ala Val Thr His Asp Lys Asn Thr Cys Ile Ile Tyr Glu Ser 
    290                 295                 300                 


His Val 
305     


<210>  562
<211>  981
<212>  PRT
<213>  Homo sapiens

<400>  562

Met Leu Arg Arg Pro Ala Pro Ala Leu Ala Pro Ala Ala Arg Leu Leu 
1               5                   10                  15      


Leu Ala Gly Leu Leu Cys Gly Gly Gly Val Trp Ala Ala Arg Val Asn 
            20                  25                  30          


Lys His Lys Pro Trp Leu Glu Pro Thr Tyr His Gly Ile Val Thr Glu 
        35                  40                  45              


Asn Asp Asn Thr Val Leu Leu Asp Pro Pro Leu Ile Ala Leu Asp Lys 
    50                  55                  60                  


Asp Ala Pro Leu Arg Phe Ala Glu Ser Phe Glu Val Thr Val Thr Lys 
65                  70                  75                  80  


Glu Gly Glu Ile Cys Gly Phe Lys Ile His Gly Gln Asn Val Pro Phe 
                85                  90                  95      


Asp Ala Val Val Val Asp Lys Ser Thr Gly Glu Gly Val Ile Arg Ser 
            100                 105                 110         


Lys Glu Lys Leu Asp Cys Glu Leu Gln Lys Asp Tyr Ser Phe Thr Ile 
        115                 120                 125             


Gln Ala Tyr Asp Cys Gly Lys Gly Pro Asp Gly Thr Asn Val Lys Lys 
    130                 135                 140                 


Ser His Lys Ala Thr Val His Ile Gln Val Asn Asp Val Asn Glu Tyr 
145                 150                 155                 160 


Ala Pro Val Phe Lys Glu Lys Ser Tyr Lys Ala Thr Val Ile Glu Gly 
                165                 170                 175     


Lys Gln Tyr Asp Ser Ile Leu Arg Val Glu Ala Val Asp Ala Asp Cys 
            180                 185                 190         


Ser Pro Gln Phe Ser Gln Ile Cys Ser Tyr Glu Ile Ile Thr Pro Asp 
        195                 200                 205             


Val Pro Phe Thr Val Asp Lys Asp Gly Tyr Ile Lys Asn Thr Glu Lys 
    210                 215                 220                 


Leu Asn Tyr Gly Lys Glu His Gln Tyr Lys Leu Thr Val Thr Ala Tyr 
225                 230                 235                 240 


Asp Cys Gly Lys Lys Arg Ala Thr Glu Asp Val Leu Val Lys Ile Ser 
                245                 250                 255     


Ile Lys Pro Thr Cys Thr Pro Gly Trp Gln Gly Trp Asn Asn Arg Ile 
            260                 265                 270         


Glu Tyr Glu Pro Gly Thr Gly Ala Leu Ala Val Phe Pro Asn Ile His 
        275                 280                 285             


Leu Glu Thr Cys Asp Glu Pro Val Ala Ser Val Gln Ala Thr Val Glu 
    290                 295                 300                 


Leu Glu Thr Ser His Ile Gly Lys Gly Cys Asp Arg Asp Thr Tyr Ser 
305                 310                 315                 320 


Glu Lys Ser Leu His Arg Leu Cys Gly Ala Ala Ala Gly Thr Ala Glu 
                325                 330                 335     


Leu Leu Pro Ser Pro Ser Gly Ser Leu Asn Trp Thr Met Gly Leu Pro 
            340                 345                 350         


Thr Asp Asn Gly His Asp Ser Asp Gln Val Phe Glu Phe Asn Gly Thr 
        355                 360                 365             


Gln Ala Val Arg Ile Pro Asp Gly Val Val Ser Val Ser Pro Lys Glu 
    370                 375                 380                 


Pro Phe Thr Ile Ser Val Trp Met Arg His Gly Pro Phe Gly Arg Lys 
385                 390                 395                 400 


Lys Glu Thr Ile Leu Cys Ser Ser Asp Lys Thr Asp Met Asn Arg His 
                405                 410                 415     


His Tyr Ser Leu Tyr Val His Gly Cys Arg Leu Ile Phe Leu Phe Arg 
            420                 425                 430         


Gln Asp Pro Ser Glu Glu Lys Lys Tyr Arg Pro Ala Glu Phe His Trp 
        435                 440                 445             


Lys Leu Asn Gln Val Cys Asp Glu Glu Trp His His Tyr Val Leu Asn 
    450                 455                 460                 


Val Glu Phe Pro Ser Val Thr Leu Tyr Val Asp Gly Thr Ser His Glu 
465                 470                 475                 480 


Pro Phe Ser Val Thr Glu Asp Tyr Pro Leu His Pro Ser Lys Ile Glu 
                485                 490                 495     


Thr Gln Leu Val Val Gly Ala Cys Trp Gln Glu Phe Ser Gly Val Glu 
            500                 505                 510         


Asn Asp Asn Glu Thr Glu Pro Val Thr Val Ala Ser Ala Gly Gly Asp 
        515                 520                 525             


Leu His Met Thr Gln Phe Phe Arg Gly Asn Leu Ala Gly Leu Thr Leu 
    530                 535                 540                 


Arg Ser Gly Lys Leu Ala Asp Lys Lys Val Ile Asp Cys Leu Tyr Thr 
545                 550                 555                 560 


Cys Lys Glu Gly Leu Asp Leu Gln Val Leu Glu Asp Ser Gly Arg Gly 
                565                 570                 575     


Val Gln Ile Gln Ala His Pro Ser Gln Leu Val Leu Thr Leu Glu Gly 
            580                 585                 590         


Glu Asp Leu Gly Glu Leu Asp Lys Ala Met Gln His Ile Ser Tyr Leu 
        595                 600                 605             


Asn Ser Arg Gln Phe Pro Thr Pro Gly Ile Arg Arg Leu Lys Ile Thr 
    610                 615                 620                 


Ser Thr Ile Lys Cys Phe Asn Glu Ala Thr Cys Ile Ser Val Pro Pro 
625                 630                 635                 640 


Val Asp Gly Tyr Val Met Val Leu Gln Pro Glu Glu Pro Lys Ile Ser 
                645                 650                 655     


Leu Ser Gly Val His His Phe Ala Arg Ala Ala Ser Glu Phe Glu Ser 
            660                 665                 670         


Ser Glu Gly Val Phe Leu Phe Pro Glu Leu Arg Ile Ile Ser Thr Ile 
        675                 680                 685             


Thr Arg Glu Val Glu Pro Glu Gly Asp Gly Ala Glu Asp Pro Thr Val 
    690                 695                 700                 


Gln Glu Ser Leu Val Ser Glu Glu Ile Val His Asp Leu Asp Thr Cys 
705                 710                 715                 720 


Glu Val Thr Val Glu Gly Glu Glu Leu Asn His Glu Gln Glu Ser Leu 
                725                 730                 735     


Glu Val Asp Met Ala Arg Leu Gln Gln Lys Gly Ile Glu Val Ser Ser 
            740                 745                 750         


Ser Glu Leu Gly Met Thr Phe Thr Gly Val Asp Thr Met Ala Ser Tyr 
        755                 760                 765             


Glu Glu Val Leu His Leu Leu Arg Tyr Arg Asn Trp His Ala Arg Ser 
    770                 775                 780                 


Leu Leu Asp Arg Lys Phe Lys Leu Ile Cys Ser Glu Leu Asn Gly Arg 
785                 790                 795                 800 


Tyr Ile Ser Asn Glu Phe Lys Val Glu Val Asn Val Ile His Thr Ala 
                805                 810                 815     


Asn Pro Met Glu His Ala Asn His Met Ala Ala Gln Pro Gln Phe Val 
            820                 825                 830         


His Pro Glu His Arg Ser Phe Val Asp Leu Ser Gly His Asn Leu Ala 
        835                 840                 845             


Asn Pro His Pro Phe Ala Val Val Pro Ser Thr Ala Thr Val Val Ile 
    850                 855                 860                 


Val Val Cys Val Ser Phe Leu Val Phe Met Ile Ile Leu Gly Val Phe 
865                 870                 875                 880 


Arg Ile Arg Ala Ala His Arg Arg Thr Met Arg Asp Gln Asp Thr Gly 
                885                 890                 895     


Lys Glu Asn Glu Met Asp Trp Asp Asp Ser Ala Leu Thr Ile Thr Val 
            900                 905                 910         


Asn Pro Met Glu Thr Tyr Glu Asp Gln His Ser Ser Glu Glu Glu Glu 
        915                 920                 925             


Glu Glu Glu Glu Glu Glu Glu Ser Glu Asp Gly Glu Glu Glu Asp Asp 
    930                 935                 940                 


Ile Thr Ser Ala Glu Ser Glu Ser Ser Glu Glu Glu Glu Gly Glu Gln 
945                 950                 955                 960 


Gly Asp Pro Gln Asn Ala Thr Arg Gln Gln Gln Leu Glu Trp Asp Asp 
                965                 970                 975     


Ser Thr Leu Ser Tyr 
            980     


<210>  563
<211>  1068
<212>  PRT
<213>  Homo sapiens

<400>  563

Met Val Ser Ser Asp Arg Pro Val Ser Leu Glu Asp Glu Val Ser His 
1               5                   10                  15      


Ser Met Lys Glu Met Ile Gly Gly Cys Cys Val Cys Ser Asp Glu Arg 
            20                  25                  30          


Gly Trp Ala Glu Asn Pro Leu Val Tyr Cys Asp Gly His Gly Cys Ser 
        35                  40                  45              


Val Ala Val His Gln Ala Cys Tyr Gly Ile Val Gln Val Pro Thr Gly 
    50                  55                  60                  


Pro Trp Phe Cys Arg Lys Cys Glu Ser Gln Glu Arg Ala Ala Arg Val 
65                  70                  75                  80  


Arg Cys Glu Leu Cys Pro His Lys Asp Gly Ala Leu Lys Arg Thr Asp 
                85                  90                  95      


Asn Gly Gly Trp Ala His Val Val Cys Ala Leu Tyr Ile Pro Glu Val 
            100                 105                 110         


Gln Phe Ala Asn Val Ser Thr Met Glu Pro Ile Val Leu Gln Ser Val 
        115                 120                 125             


Pro His Asp Arg Tyr Asn Lys Thr Cys Tyr Ile Cys Asp Glu Gln Gly 
    130                 135                 140                 


Arg Glu Ser Lys Ala Ala Thr Gly Ala Cys Met Thr Cys Asn Lys His 
145                 150                 155                 160 


Gly Cys Arg Gln Ala Phe His Val Thr Cys Ala Gln Phe Ala Gly Leu 
                165                 170                 175     


Leu Cys Glu Glu Glu Gly Asn Gly Ala Asp Asn Val Gln Tyr Cys Gly 
            180                 185                 190         


Tyr Cys Lys Tyr His Phe Ser Lys Leu Lys Lys Ser Lys Arg Gly Ser 
        195                 200                 205             


Asn Arg Ser Tyr Asp Gln Ser Leu Ser Asp Ser Ser Ser His Ser Gln 
    210                 215                 220                 


Asp Lys His His Glu Lys Glu Lys Lys Lys Tyr Lys Glu Lys Asp Lys 
225                 230                 235                 240 


His Lys Gln Lys His Lys Lys Gln Pro Glu Pro Ser Pro Ala Leu Val 
                245                 250                 255     


Pro Ser Leu Thr Val Thr Thr Glu Lys Thr Tyr Thr Ser Thr Ser Asn 
            260                 265                 270         


Asn Ser Ile Ser Gly Ser Leu Lys Arg Leu Glu Asp Thr Thr Ala Arg 
        275                 280                 285             


Phe Thr Asn Ala Asn Phe Gln Glu Val Ser Ala His Thr Ser Ser Gly 
    290                 295                 300                 


Lys Asp Val Ser Glu Thr Arg Gly Ser Glu Gly Lys Gly Lys Lys Ser 
305                 310                 315                 320 


Ser Ala His Ser Ser Gly Gln Arg Gly Arg Lys Pro Gly Gly Gly Arg 
                325                 330                 335     


Asn Pro Gly Thr Thr Val Ser Ala Ala Ser Pro Phe Pro Gln Gly Ser 
            340                 345                 350         


Phe Ser Gly Thr Pro Gly Ser Val Lys Ser Ser Ser Gly Ser Ser Val 
        355                 360                 365             


Gln Ser Pro Gln Asp Phe Leu Ser Phe Thr Asp Ser Asp Leu Arg Asn 
    370                 375                 380                 


Asp Ser Tyr Ser His Ser Gln Gln Ser Ser Ala Thr Lys Asp Val His 
385                 390                 395                 400 


Lys Gly Glu Ser Gly Ser Gln Glu Gly Gly Val Asn Ser Phe Ser Thr 
                405                 410                 415     


Leu Ile Gly Leu Pro Ser Thr Ser Ala Val Thr Ser Gln Pro Lys Ser 
            420                 425                 430         


Phe Glu Asn Ser Pro Gly Asp Leu Gly Asn Ser Ser Leu Pro Thr Ala 
        435                 440                 445             


Gly Tyr Lys Arg Ala Gln Thr Ser Gly Ile Glu Glu Glu Thr Val Lys 
    450                 455                 460                 


Glu Lys Lys Arg Lys Gly Asn Lys Gln Ser Lys His Gly Pro Gly Arg 
465                 470                 475                 480 


Pro Lys Gly Asn Lys Asn Gln Glu Asn Val Ser His Leu Ser Val Ser 
                485                 490                 495     


Ser Ala Ser Pro Thr Ser Ser Val Ala Ser Ala Ala Gly Ser Ile Thr 
            500                 505                 510         


Ser Ser Ser Leu Gln Lys Ser Pro Thr Leu Leu Arg Asn Gly Ser Leu 
        515                 520                 525             


Gln Ser Leu Ser Val Gly Ser Ser Pro Val Gly Ser Glu Ile Ser Met 
    530                 535                 540                 


Gln Tyr Arg His Asp Gly Ala Cys Pro Thr Thr Thr Phe Ser Glu Leu 
545                 550                 555                 560 


Leu Asn Ala Ile His Asn Gly Ile Tyr Asn Ser Asn Asp Val Ala Val 
                565                 570                 575     


Ser Phe Pro Asn Val Val Ser Gly Ser Gly Ser Ser Thr Pro Val Ser 
            580                 585                 590         


Ser Ser His Leu Pro Gln Gln Ser Ser Gly His Leu Gln Gln Val Gly 
        595                 600                 605             


Ala Leu Ser Pro Ser Ala Val Ser Ser Ala Ala Pro Ala Val Ala Thr 
    610                 615                 620                 


Thr Gln Ala Asn Thr Leu Ser Gly Ser Ser Leu Ser Gln Ala Pro Ser 
625                 630                 635                 640 


His Met Tyr Gly Asn Arg Ser Asn Ser Ser Met Ala Ala Leu Ile Ala 
                645                 650                 655     


Gln Ser Glu Asn Asn Gln Thr Asp Gln Asp Leu Gly Asp Asn Ser Arg 
            660                 665                 670         


Asn Leu Val Gly Arg Gly Ser Ser Pro Arg Gly Ser Leu Ser Pro Arg 
        675                 680                 685             


Ser Pro Val Ser Ser Leu Gln Ile Arg Tyr Asp Gln Pro Gly Asn Ser 
    690                 695                 700                 


Ser Leu Glu Asn Leu Pro Pro Val Ala Ala Ser Ile Glu Gln Leu Leu 
705                 710                 715                 720 


Glu Arg Gln Trp Ser Glu Gly Gln Gln Phe Leu Leu Glu Gln Gly Thr 
                725                 730                 735     


Pro Ser Asp Ile Leu Gly Met Leu Lys Ser Leu His Gln Leu Gln Val 
            740                 745                 750         


Glu Asn Arg Arg Leu Glu Glu Gln Ile Lys Asn Leu Thr Ala Lys Lys 
        755                 760                 765             


Glu Arg Leu Gln Leu Leu Asn Ala Gln Leu Ser Val Pro Phe Pro Thr 
    770                 775                 780                 


Ile Thr Ala Asn Pro Ser Pro Ser His Gln Ile His Thr Phe Ser Ala 
785                 790                 795                 800 


Gln Thr Ala Pro Thr Thr Asp Ser Leu Asn Ser Ser Lys Ser Pro His 
                805                 810                 815     


Ile Gly Asn Ser Phe Leu Pro Asp Asn Ser Leu Pro Val Leu Asn Gln 
            820                 825                 830         


Asp Leu Thr Ser Ser Gly Gln Ser Thr Ser Ser Ser Ser Ala Leu Ser 
        835                 840                 845             


Thr Pro Pro Pro Ala Gly Gln Ser Pro Ala Gln Gln Gly Ser Gly Val 
    850                 855                 860                 


Ser Gly Val Gln Gln Val Asn Gly Val Thr Val Gly Ala Leu Ala Ser 
865                 870                 875                 880 


Gly Met Gln Pro Val Thr Ser Thr Ile Pro Ala Val Ser Ala Val Gly 
                885                 890                 895     


Gly Ile Ile Gly Ala Leu Pro Gly Asn Gln Leu Ala Ile Asn Gly Ile 
            900                 905                 910         


Val Gly Ala Leu Asn Gly Val Met Gln Thr Pro Val Thr Met Ser Gln 
        915                 920                 925             


Asn Pro Thr Pro Leu Thr His Thr Thr Val Pro Pro Asn Ala Thr His 
    930                 935                 940                 


Pro Met Pro Ala Thr Leu Thr Asn Ser Ala Ser Gly Leu Gly Leu Leu 
945                 950                 955                 960 


Ser Asp Gln Gln Arg Gln Ile Leu Ile His Gln Gln Gln Phe Gln Gln 
                965                 970                 975     


Leu Leu Asn Ser Gln Gln Leu Thr Pro Glu Gln His Gln Ala Phe Leu 
            980                 985                 990         


Tyr Gln Leu Met Gln His His His  Gln Gln His His Gln  Pro Glu Leu 
        995                 1000                 1005             


Gln Gln  Leu Gln Ile Pro Gly  Pro Thr Gln Ile Pro  Ile Asn Asn 
    1010                 1015                 1020             


Leu Leu  Ala Gly Thr Gln Ala  Pro Pro Leu His Thr  Ala Thr Thr 
    1025                 1030                 1035             


Asn Pro  Phe Leu Thr Ile His  Gly Asp Asn Ala Ser  Gln Lys Val 
    1040                 1045                 1050             


Ala Arg  Leu Ser Asp Lys Thr  Gly Pro Val Ala Gln  Glu Lys Ser 
    1055                 1060                 1065             


<210>  564
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  564

Met Asp Arg Arg Met Trp Gly Ala His Val Phe Cys Val Leu Ser Pro 
1               5                   10                  15      


Leu Pro Thr Val Leu Gly His Met His Pro Glu Cys Asp Phe Ile Thr 
            20                  25                  30          


Gln Leu Arg Glu Asp Glu Ser Ala Cys Leu Gln Ala Ala Glu Glu Met 
        35                  40                  45              


Pro Asn Thr Thr Leu Gly Cys Pro Ala Thr Trp Asp Gly Leu Leu Cys 
    50                  55                  60                  


Trp Pro Thr Ala Gly Ser Gly Glu Trp Val Thr Leu Pro Cys Pro Asp 
65                  70                  75                  80  


Phe Phe Ser His Phe Ser Ser Glu Ser Gly Ala Val Lys Arg Asp Cys 
                85                  90                  95      


Thr Ile Thr Gly Trp Ser Glu Pro Phe Pro Pro Tyr Pro Val Ala Cys 
            100                 105                 110         


Pro Val Pro Leu Glu Leu Leu Ala Glu Glu Glu Ser Tyr Phe Ser Thr 
        115                 120                 125             


Val Lys Ile Ile Tyr Thr Val Gly His Ser Ile Ser Ile Val Ala Leu 
    130                 135                 140                 


Phe Val Ala Ile Thr Ile Leu Val Ala Leu Arg Arg Leu His Cys Pro 
145                 150                 155                 160 


Arg Asn Tyr Val His Thr Gln Leu Phe Thr Thr Phe Ile Leu Lys Ala 
                165                 170                 175     


Gly Ala Val Phe Leu Lys Asp Ala Ala Leu Phe His Ser Asp Asp Thr 
            180                 185                 190         


Asp His Cys Ser Phe Ser Thr Val Leu Cys Lys Val Ser Val Ala Ala 
        195                 200                 205             


Ser His Phe Ala Thr Met Thr Asn Phe Ser Trp Leu Leu Ala Glu Ala 
    210                 215                 220                 


Val Tyr Leu Asn Cys Leu Leu Ala Ser Thr Ser Pro Ser Ser Arg Arg 
225                 230                 235                 240 


Ala Phe Trp Trp Leu Val Leu Ala Gly Trp Gly Leu Pro Val Leu Phe 
                245                 250                 255     


Thr Gly Thr Trp Val Ser Cys Lys Leu Ala Phe Glu Asp Ile Ala Cys 
            260                 265                 270         


Trp Asp Leu Asp Asp Thr Ser Pro Tyr Trp Trp Ile Ile Lys Gly Pro 
        275                 280                 285             


Ile Val Leu Ser Val Gly Val Asn Phe Gly Leu Phe Leu Asn Ile Ile 
    290                 295                 300                 


Arg Ile Leu Val Arg Lys Leu Glu Pro Ala Gln Gly Ser Leu His Thr 
305                 310                 315                 320 


Gln Ser Gln Tyr Trp Arg Leu Ser Lys Ser Thr Leu Phe Leu Ile Pro 
                325                 330                 335     


Leu Phe Gly Ile His Tyr Ile Ile Phe Asn Phe Leu Pro Asp Asn Ala 
            340                 345                 350         


Gly Leu Gly Ile Arg Leu Pro Leu Glu Leu Gly Leu Gly Ser Phe Gln 
        355                 360                 365             


Gly Phe Ile Val Ala Ile Leu Tyr Cys Phe Leu Asn Gln Glu Val Arg 
    370                 375                 380                 


Thr Glu Ile Ser Arg Lys Trp His Gly His Asp Pro Glu Leu Leu Pro 
385                 390                 395                 400 


Ala Trp Arg Thr Arg Ala Lys Trp Thr Thr Pro Ser Arg Ser Ala Ala 
                405                 410                 415     


Lys Val Leu Thr Ser Met Cys 
            420             


<210>  565
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  565

Met Gln Pro Trp Ala Leu Pro Thr Val Gly Glu Leu Trp Val Cys Gly 
1               5                   10                  15      


Arg Pro Gly Ala Ala Leu Arg Trp Ser Leu Val Leu Ser Pro Arg Leu 
            20                  25                  30          


Glu Pro Ser Gly Val Ile Ser Ala His Cys Asn Leu His Leu Leu Ala 
        35                  40                  45              


Ser Ser Asp Ser Ser Ala Ser Ala Ser Arg Leu Cys Gln Arg Val Met 
    50                  55                  60                  


Met Pro Ser Arg Thr Asn Leu Ala Thr Gly Ile Pro Ser Ser Lys Val 
65                  70                  75                  80  


Lys Tyr Ser Arg Leu Ser Ser Thr Asp Asp Gly Tyr Ile Asp Leu Gln 
                85                  90                  95      


Phe Lys Lys Thr Pro Pro Lys Ile Pro Tyr Lys Ala Ile Ala Leu Ala 
            100                 105                 110         


Thr Val Leu Phe Leu Ile Gly Ala Phe Leu Ile Ile Ile Gly Ser Leu 
        115                 120                 125             


Leu Leu Ser Gly Tyr Ile Ser Lys Gly Gly Ala Asp Arg Ala Val Pro 
    130                 135                 140                 


Val Leu Ile Ile Gly Ile Leu Val Phe Leu Pro Gly Phe Tyr His Leu 
145                 150                 155                 160 


Arg Ile Ala Tyr Tyr Ala Ser Lys Gly Tyr Arg Gly Tyr Ser Tyr Asp 
                165                 170                 175     


Asp Ile Pro Asp Phe Asp Asp 
            180             


<210>  566
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  566

Met Met Pro Ser Arg Thr Asn Leu Ala Thr Gly Ile Pro Ser Ser Lys 
1               5                   10                  15      


Val Lys Tyr Ser Arg Leu Ser Ser Thr Asp Asp Gly Tyr Ile Asp Leu 
            20                  25                  30          


Gln Phe Lys Lys Thr Pro Pro Lys Ile Pro Tyr Lys Ala Ile Ala Leu 
        35                  40                  45              


Ala Thr Val Leu Phe Leu Ile Gly Ala Phe Leu Ile Ile Ile Gly Ser 
    50                  55                  60                  


Leu Leu Leu Ser Gly Tyr Ile Ser Lys Gly Gly Ala Asp Arg Ala Val 
65                  70                  75                  80  


Pro Val Leu Ile Ile Gly Ile Leu Val Phe Leu Pro Gly Phe Tyr His 
                85                  90                  95      


Leu Arg Ile Ala Tyr Tyr Ala Ser Lys Gly Tyr Arg Gly Tyr Ser Tyr 
            100                 105                 110         


Asp Asp Ile Pro Asp Phe Asp Asp 
        115                 120 


<210>  567
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  567

Met Met Pro Ser Arg Thr Asn Leu Ala Thr Gly Ile Pro Ser Ser Lys 
1               5                   10                  15      


Val Lys Tyr Ser Arg Leu Ser Ser Thr Asp Asp Gly Tyr Ile Asp Leu 
            20                  25                  30          


Gln Phe Lys Lys Thr Pro Pro Lys Ile Pro Tyr Lys Ala Ile Ala Leu 
        35                  40                  45              


Ala Thr Val Leu Phe Leu Ile Gly Ala Phe Leu Ile Ile Ile Gly Ser 
    50                  55                  60                  


Leu Leu Leu Ser Gly Tyr Ile Ser Lys Gly Gly Ala Asp Arg Ala Val 
65                  70                  75                  80  


Pro Val Leu Ile Ile Gly Ile Leu Val Phe Leu Pro Gly Phe Tyr His 
                85                  90                  95      


Leu Arg Ile Ala Tyr Tyr Ala Ser Lys Gly Tyr Arg Gly Tyr Ser Tyr 
            100                 105                 110         


Asp Asp Ile Pro Asp Phe Asp Asp 
        115                 120 


<210>  568
<211>  363
<212>  PRT
<213>  Homo sapiens

<400>  568

Met Tyr Ala Lys Gly Gly Lys Gly Ser Ala Val Pro Ser Asp Ser Gln 
1               5                   10                  15      


Ala Arg Glu Lys Leu Ala Leu Tyr Val Tyr Glu Tyr Leu Leu His Ile 
            20                  25                  30          


Gly Ala Gln Lys Ser Ala Gln Thr Phe Leu Ser Glu Ile Arg Trp Glu 
        35                  40                  45              


Lys Asn Ile Thr Leu Gly Glu Pro Pro Gly Phe Leu His Ser Trp Trp 
    50                  55                  60                  


Cys Val Phe Trp Asp Leu Tyr Cys Ala Ala Pro Asp Arg Arg Glu Ala 
65                  70                  75                  80  


Cys Glu His Ser Gly Glu Ala Lys Ala Phe Gln Asp Tyr Ser Ala Ala 
                85                  90                  95      


Ala Ala Pro Ser Pro Val Met Gly Ser Met Ala Pro Gly Asp Thr Met 
            100                 105                 110         


Ala Ala Gly Ser Met Ala Ala Gly Phe Phe Gln Pro Phe Met Ser Pro 
        115                 120                 125             


Arg Phe Pro Gly Gly Pro Arg Pro Thr Leu Arg Met Pro Ser Gln Pro 
    130                 135                 140                 


Pro Ala Gly Leu Pro Gly Ser Gln Pro Leu Leu Pro Gly Ala Met Glu 
145                 150                 155                 160 


Pro Ser Pro Arg Ala Gln Gly His Pro Ser Met Gly Gly Pro Met Gln 
                165                 170                 175     


Arg Val Thr Pro Pro Arg Gly Met Ala Ser Val Gly Pro Gln Ser Tyr 
            180                 185                 190         


Gly Gly Gly Met Arg Pro Pro Pro Asn Ser Leu Ala Gly Pro Gly Leu 
        195                 200                 205             


Pro Ala Met Asn Met Gly Pro Gly Val Arg Gly Pro Trp Ala Ser Pro 
    210                 215                 220                 


Ser Gly Asn Ser Ile Pro Tyr Ser Ser Ser Ser Pro Gly Ser Tyr Thr 
225                 230                 235                 240 


Gly Pro Pro Gly Gly Gly Gly Pro Pro Gly Thr Pro Ile Met Pro Ser 
                245                 250                 255     


Pro Gly Asp Ser Thr Asn Ser Ser Glu Asn Met Tyr Thr Ile Met Asn 
            260                 265                 270         


Pro Ile Gly Gln Gly Ala Gly Arg Ala Asn Phe Pro Leu Gly Pro Gly 
        275                 280                 285             


Pro Glu Gly Pro Met Ala Ala Met Ser Ala Met Glu Pro His His Val 
    290                 295                 300                 


Asn Gly Ser Leu Gly Ser Gly Asp Met Asp Gly Leu Pro Lys Ser Ser 
305                 310                 315                 320 


Pro Gly Ala Val Ala Gly Leu Ser Asn Ala Pro Gly Thr Pro Arg Asp 
                325                 330                 335     


Asp Gly Glu Met Ala Ala Ala Gly Thr Phe Leu His Pro Phe Pro Ser 
            340                 345                 350         


Glu Ser Tyr Ser Pro Gly Met Thr Met Ser Val 
        355                 360             


<210>  569
<211>  696
<212>  PRT
<213>  Homo sapiens

<400>  569

Met Ser Glu Gly Ala Ala Ala Ala Ser Pro Pro Gly Ala Ala Ser Ala 
1               5                   10                  15      


Ala Ala Ala Ser Ala Glu Glu Gly Thr Ala Ala Ala Ala Ala Ala Ala 
            20                  25                  30          


Ala Ala Gly Gly Gly Pro Asp Gly Gly Gly Glu Gly Ala Ala Glu Pro 
        35                  40                  45              


Pro Arg Glu Leu Arg Cys Ser Asp Cys Ile Val Trp Asn Arg Gln Gln 
    50                  55                  60                  


Thr Trp Leu Cys Val Val Pro Leu Phe Ile Gly Phe Ile Gly Leu Gly 
65                  70                  75                  80  


Leu Ser Leu Met Leu Leu Lys Trp Ile Val Val Gly Ser Val Lys Glu 
                85                  90                  95      


Tyr Val Pro Thr Asp Leu Val Asp Ser Lys Gly Met Gly Gln Asp Pro 
            100                 105                 110         


Phe Phe Leu Ser Lys Pro Ser Ser Phe Pro Lys Ala Met Glu Thr Thr 
        115                 120                 125             


Thr Thr Thr Thr Ser Thr Thr Ser Pro Ala Thr Pro Ser Ala Gly Gly 
    130                 135                 140                 


Ala Ala Ser Ser Arg Thr Pro Asn Arg Ile Ser Thr Arg Leu Thr Thr 
145                 150                 155                 160 


Ile Thr Arg Ala Pro Thr Arg Phe Pro Gly His Arg Val Pro Ile Arg 
                165                 170                 175     


Ala Ser Pro Arg Ser Thr Thr Ala Arg Asn Thr Ala Ala Pro Ala Thr 
            180                 185                 190         


Val Pro Ser Thr Thr Ala Pro Phe Phe Ser Ser Ser Thr Leu Gly Ser 
        195                 200                 205             


Arg Pro Pro Val Pro Gly Thr Pro Ser Thr Gln Ala Met Pro Ser Trp 
    210                 215                 220                 


Pro Thr Ala Ala Tyr Ala Thr Ser Ser Tyr Leu His Asp Ser Thr Pro 
225                 230                 235                 240 


Ser Trp Thr Leu Ser Pro Phe Gln Asp Ala Ala Ser Ser Ser Ser Ser 
                245                 250                 255     


Ser Ser Ser Ser Ala Thr Thr Thr Thr Pro Glu Thr Ser Thr Ser Pro 
            260                 265                 270         


Lys Phe His Thr Thr Thr Tyr Ser Thr Glu Arg Ser Glu His Phe Lys 
        275                 280                 285             


Pro Cys Arg Asp Lys Asp Leu Ala Tyr Cys Leu Asn Asp Gly Glu Cys 
    290                 295                 300                 


Phe Val Ile Glu Thr Leu Thr Gly Ser His Lys His Cys Arg Cys Lys 
305                 310                 315                 320 


Glu Gly Tyr Gln Gly Val Arg Cys Asp Gln Phe Leu Pro Lys Thr Asp 
                325                 330                 335     


Ser Ile Leu Ser Asp Pro Thr Asp His Leu Gly Ile Glu Phe Met Glu 
            340                 345                 350         


Ser Glu Glu Val Tyr Gln Arg Gln Val Leu Ser Ile Ser Cys Ile Ile 
        355                 360                 365             


Phe Gly Ile Val Ile Val Gly Met Phe Cys Ala Ala Phe Tyr Phe Lys 
    370                 375                 380                 


Ser Lys Lys Gln Ala Lys Gln Ile Gln Glu Gln Leu Lys Val Pro Gln 
385                 390                 395                 400 


Asn Gly Lys Ser Tyr Ser Leu Lys Ala Ser Ser Thr Met Ala Lys Ser 
                405                 410                 415     


Glu Asn Leu Val Lys Ser His Val Gln Leu Gln Asn Tyr Ser Lys Val 
            420                 425                 430         


Glu Arg His Pro Val Thr Ala Leu Glu Lys Met Met Glu Ser Ser Phe 
        435                 440                 445             


Val Gly Pro Gln Ser Phe Pro Glu Val Pro Ser Pro Asp Arg Gly Ser 
    450                 455                 460                 


Gln Ser Val Lys His His Arg Ser Leu Ser Ser Cys Cys Ser Pro Gly 
465                 470                 475                 480 


Gln Arg Ser Gly Met Leu His Arg Asn Ala Phe Arg Arg Thr Pro Pro 
                485                 490                 495     


Ser Pro Arg Ser Arg Leu Gly Gly Ile Val Gly Pro Ala Tyr Gln Gln 
            500                 505                 510         


Leu Glu Glu Ser Arg Ile Pro Asp Gln Asp Thr Ile Pro Cys Gln Gly 
        515                 520                 525             


Tyr Ser Ser Ser Gly Leu Lys Thr Gln Arg Asn Thr Ser Ile Asn Met 
    530                 535                 540                 


Gln Leu Pro Ser Arg Glu Thr Asn Pro Tyr Phe Asn Ser Leu Glu Gln 
545                 550                 555                 560 


Lys Asp Leu Val Gly Tyr Ser Ser Thr Arg Ala Ser Ser Val Pro Ile 
                565                 570                 575     


Ile Pro Ser Val Gly Leu Glu Glu Thr Cys Leu Gln Met Pro Gly Ile 
            580                 585                 590         


Ser Glu Val Lys Ser Ile Lys Trp Cys Lys Asn Ser Tyr Ser Ala Asp 
        595                 600                 605             


Val Val Asn Val Ser Ile Pro Val Ser Asp Cys Leu Ile Ala Glu Gln 
    610                 615                 620                 


Gln Glu Val Lys Ile Leu Leu Glu Thr Val Gln Glu Gln Ile Arg Ile 
625                 630                 635                 640 


Leu Thr Asp Ala Arg Arg Ser Glu Asp Tyr Glu Leu Ala Ser Val Glu 
                645                 650                 655     


Thr Glu Asp Ser Ala Ser Glu Asn Thr Ala Phe Leu Pro Leu Ser Pro 
            660                 665                 670         


Thr Ala Lys Ser Glu Arg Glu Ala Gln Phe Val Leu Arg Asn Glu Ile 
        675                 680                 685             


Gln Arg Asp Ser Ala Leu Thr Lys 
    690                 695     


<210>  570
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  570

Met Pro Leu Leu Pro Ala Ala Leu Thr Ser Ser Met Leu Tyr Phe Gln 
1               5                   10                  15      


Met Val Ile Met Ala Gly Thr Val Met Leu Ala Tyr Tyr Phe Glu Tyr 
            20                  25                  30          


Thr Asp Thr Phe Thr Val Asn Val Gln Gly Phe Phe Cys His Asp Ser 
        35                  40                  45              


Ala Tyr Arg Lys Pro Tyr Pro Gly Pro Glu Asp Ser Ser Ala Val Pro 
    50                  55                  60                  


Pro Val Leu Leu Tyr Ser Leu Ala Ala Gly Val Pro Val Leu Val Ile 
65                  70                  75                  80  


Ile Val Gly Glu Thr Ala Val Phe Cys Leu Gln Leu Ala Thr Arg Asp 
                85                  90                  95      


Phe Glu Asn Gln Glu Lys Thr Ile Leu Thr Gly Asp Cys Cys Tyr Ile 
            100                 105                 110         


Asn Pro Leu Val Arg Arg Thr Val Arg Phe Leu Gly Ile Tyr Thr Phe 
        115                 120                 125             


Gly Leu Phe Ala Thr Asp Ile Phe Val Asn Ala Gly Gln Val Val Thr 
    130                 135                 140                 


Gly Asn Leu Ala Pro His Phe Leu Ala Leu Cys Lys Pro Asn Tyr Thr 
145                 150                 155                 160 


Ala Leu Gly Cys Gln Gln Tyr Thr Gln Phe Ile Ser Gly Glu Glu Ala 
                165                 170                 175     


Cys Thr Gly Asn Pro Asp Leu Ile Met Arg Ala Arg Lys Thr Phe Pro 
            180                 185                 190         


Ser Lys Glu Ala Ala Leu Ser Val Tyr Ala Ala Met Tyr Leu Thr Met 
        195                 200                 205             


Tyr Ile Thr Asn Thr Ile Lys Ala Lys Gly Thr Arg Leu Ala Lys Pro 
    210                 215                 220                 


Val Leu Cys Leu Gly Leu Met Cys Leu Ala Phe Leu Thr Gly Leu Asn 
225                 230                 235                 240 


Arg Val Ala Glu Tyr Arg Asn His Trp Ser Asp Val Ile Ala Gly Phe 
                245                 250                 255     


Leu Val Gly Ile Ser Ile Ala Val Phe Leu Val Val Cys Val Val Asn 
            260                 265                 270         


Asn Phe Lys Gly Arg Gln Ala Glu Asn Glu His Ile His Met Asp Asn 
        275                 280                 285             


Leu Ala Gln Met Pro Met Ile Ser Ile Pro Arg Val Glu Ser Pro Leu 
    290                 295                 300                 


Glu Lys Asn His Ile Thr Ala Phe Ala Glu Val Thr 
305                 310                 315     


<210>  571
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  571

Met Glu Gly Val Ser Ala Leu Leu Ala Arg Cys Pro Thr Ala Gly Leu 
1               5                   10                  15      


Ala Gly Gly Leu Gly Val Thr Ala Cys Ala Ala Ala Gly Val Leu Leu 
            20                  25                  30          


Tyr Arg Ile Ala Arg Arg Met Lys Pro Thr His Thr Met Val Asn Cys 
        35                  40                  45              


Trp Phe Cys Asn Gln Asp Thr Leu Val Pro Tyr Gly Asn Arg Asn Cys 
    50                  55                  60                  


Trp Asp Cys Pro His Cys Glu Gln Tyr Asn Gly Phe Gln Glu Asn Gly 
65                  70                  75                  80  


Asp Tyr Asn Lys Pro Ile Pro Ala Gln Tyr Leu Glu His Leu Asn His 
                85                  90                  95      


Val Val Ser Ser Ala Pro Ser Leu Arg Asp Pro Ser Gln Pro Gln Gln 
            100                 105                 110         


Trp Val Ser Ser Gln Val Leu Leu Cys Lys Arg Cys Asn His His Gln 
        115                 120                 125             


Thr Thr Lys Ile Lys Gln Leu Ala Ala Phe Ala Pro Arg Glu Glu Gly 
    130                 135                 140                 


Arg Tyr Asp Glu Glu Val Glu Val Tyr Arg His His Leu Glu Gln Met 
145                 150                 155                 160 


Tyr Lys Leu Cys Arg Pro Cys Gln Ala Ala Val Glu Tyr Tyr Ile Lys 
                165                 170                 175     


His Gln Asn Arg Gln Leu Arg Ala Leu Leu Leu Ser His Gln Phe Lys 
            180                 185                 190         


Arg Arg Glu Ala Asp Gln Thr His Ala Gln Asn Phe Ser Ser Ala Val 
        195                 200                 205             


Lys Ser Pro Val Gln Val Ile Leu Leu Arg Ala Leu Ala Phe Leu Ala 
    210                 215                 220                 


Cys Ala Phe Leu Leu Thr Thr Ala Leu Tyr Gly Ala Ser Gly His Phe 
225                 230                 235                 240 


Ala Pro Gly Thr Thr Val Pro Leu Ala Leu Pro Pro Gly Gly Asn Gly 
                245                 250                 255     


Ser Ala Thr Pro Asp Asn Gly Thr Thr Pro Gly Ala Glu Gly Trp Arg 
            260                 265                 270         


Gln Leu Leu Gly Leu Leu Pro Glu His Met Ala Glu Lys Leu Cys Glu 
        275                 280                 285             


Ala Trp Ala Phe Gly Gln Ser His Gln Thr Gly Val Val Ala Leu Gly 
    290                 295                 300                 


Leu Leu Thr Cys Leu Leu Ala Met Leu Leu Ala Gly Arg Ile Arg Leu 
305                 310                 315                 320 


Arg Arg Ile Asp Ala Phe Cys Thr Cys Leu Trp Ala Leu Leu Leu Gly 
                325                 330                 335     


Leu His Leu Ala Glu Gln His Leu Gln Ala Ala Ser Pro Ser Trp Leu 
            340                 345                 350         


Asp Thr Leu Lys Phe Ser Thr Thr Ser Leu Cys Cys Leu Val Gly Phe 
        355                 360                 365             


Thr Ala Ala Val Ala Thr Arg Lys Ala Thr Gly Pro Arg Arg Phe Arg 
    370                 375                 380                 


Pro Arg Arg Ser Glu Lys Gln Pro 
385                 390         


<210>  572
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  572

Met Arg Leu Gln Gly Ala Ile Phe Val Leu Leu Pro His Leu Gly Pro 
1               5                   10                  15      


Ile Leu Val Trp Leu Phe Thr Arg Asp His Met Ser Gly Trp Cys Glu 
            20                  25                  30          


Gly Pro Arg Met Leu Ser Trp Cys Pro Phe Tyr Lys Val Leu Leu Leu 
        35                  40                  45              


Val Gln Thr Ala Ile Tyr Ser Val Val Gly Tyr Ala Ser Tyr Leu Val 
    50                  55                  60                  


Trp Lys Asp Leu Gly Gly Gly Leu Gly Trp Pro Leu Ala Leu Pro Leu 
65                  70                  75                  80  


Gly Leu Tyr Ala Val Gln Leu Thr Ile Ser Trp Thr Val Leu Val Leu 
                85                  90                  95      


Phe Phe Thr Val His Asn Pro Gly Leu Ala Leu Leu His Leu Leu Leu 
            100                 105                 110         


Leu Tyr Gly Leu Val Val Ser Thr Ala Leu Ile Trp His Pro Ile Asn 
        115                 120                 125             


Lys Leu Ala Ala Leu Leu Leu Leu Pro Tyr Leu Ala Trp Leu Thr Val 
    130                 135                 140                 


Thr Ser Ala Leu Thr Tyr His Leu Trp Arg Asp Ser Leu Cys Pro Val 
145                 150                 155                 160 


His Gln Pro Gln Pro Thr Glu Lys Ser Asp 
                165                 170 


<210>  573
<211>  363
<212>  PRT
<213>  Homo sapiens

<400>  573

Met Phe Lys Arg His Lys Ser Leu Ala Ser Glu Arg Lys Arg Ala Leu 
1               5                   10                  15      


Leu Ser Gln Arg Ala Thr Arg Phe Ile Leu Lys Asp Asp Met Arg Asn 
            20                  25                  30          


Phe His Phe Leu Ser Lys Leu Val Leu Ser Ala Gly Pro Leu Arg Pro 
        35                  40                  45              


Thr Pro Ala Val Lys His Ser Lys Thr Thr His Phe Glu Ile Glu Ile 
    50                  55                  60                  


Phe Asp Ala Gln Thr Arg Lys Gln Ile Cys Ile Leu Asp Lys Val Thr 
65                  70                  75                  80  


Gln Ser Ser Thr Ile His Asp Val Lys Gln Lys Phe His Lys Ala Cys 
                85                  90                  95      


Pro Lys Trp Tyr Pro Ser Arg Val Gly Leu Gln Leu Glu Cys Gly Gly 
            100                 105                 110         


Pro Phe Leu Lys Asp Tyr Ile Thr Ile Gln Ser Ile Ala Ala Ser Ser 
        115                 120                 125             


Ile Val Thr Leu Tyr Ala Thr Asp Leu Gly Gln Gln Val Ser Trp Thr 
    130                 135                 140                 


Thr Val Phe Leu Ala Glu Tyr Thr Gly Pro Leu Leu Ile Tyr Leu Leu 
145                 150                 155                 160 


Phe Tyr Leu Arg Ile Pro Cys Ile Tyr Asp Gly Lys Glu Ser Ala Arg 
                165                 170                 175     


Arg Leu Arg His Pro Val Val His Leu Ala Cys Phe Cys His Cys Ile 
            180                 185                 190         


His Tyr Ile Arg Tyr Leu Leu Glu Thr Leu Phe Val His Lys Val Ser 
        195                 200                 205             


Ala Gly His Thr Pro Leu Lys Asn Leu Ile Met Ser Cys Ala Phe Tyr 
    210                 215                 220                 


Trp Gly Phe Thr Ser Trp Ile Ala Tyr Tyr Ile Asn His Pro Leu Tyr 
225                 230                 235                 240 


Thr Pro Pro Ser Phe Gly Asn Arg Gln Ile Thr Val Ser Ala Ile Asn 
                245                 250                 255     


Phe Leu Ile Cys Glu Ala Gly Asn His Phe Ile Asn Val Met Leu Ser 
            260                 265                 270         


His Pro Asn His Thr Gly Asn Asn Ala Cys Phe Pro Ser Pro Asn Tyr 
        275                 280                 285             


Asn Pro Phe Thr Trp Met Phe Phe Leu Val Ser Cys Pro Asn Tyr Thr 
    290                 295                 300                 


Tyr Glu Ile Gly Ser Trp Ile Ser Phe Thr Val Met Thr Gln Thr Leu 
305                 310                 315                 320 


Pro Val Gly Ile Phe Thr Leu Leu Met Ser Ile Gln Met Ser Leu Trp 
                325                 330                 335     


Ala Gln Lys Lys His Lys Ile Tyr Leu Arg Lys Phe Asn Ser Tyr Ile 
            340                 345                 350         


His Arg Lys Ser Ala Met Ile Pro Phe Ile Leu 
        355                 360             


<210>  574
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  574

Met Asn Arg Val Leu Cys Ala Pro Ala Ala Gly Ala Val Arg Ala Leu 
1               5                   10                  15      


Arg Leu Ile Gly Trp Ala Ser Arg Ser Leu His Pro Leu Pro Gly Ser 
            20                  25                  30          


Arg Asp Arg Ala His Pro Ala Ala Glu Glu Glu Asp Asp Pro Asp Arg 
        35                  40                  45              


Pro Ile Glu Phe Ser Ser Ser Lys Ala Asn Pro His Arg Trp Ser Val 
    50                  55                  60                  


Gly His Thr Met Gly Lys Gly His Gln Arg Pro Trp Trp Lys Val Leu 
65                  70                  75                  80  


Pro Leu Ser Cys Phe Leu Val Ala Leu Ile Ile Trp Cys Tyr Leu Arg 
                85                  90                  95      


Glu Glu Ser Glu Ala Asp Gln Trp Leu Arg Gln Val Trp Gly Glu Val 
            100                 105                 110         


Pro Glu Pro Ser Asp Arg Ser Glu Glu Pro Glu Thr Pro Ala Ala Tyr 
        115                 120                 125             


Arg Ala Arg Thr 
    130         


<210>  575
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  575

Met Val Ala Lys Gln Arg Ile Arg Met Ala Asn Glu Lys His Ser Lys 
1               5                   10                  15      


Asn Ile Thr Gln Arg Gly Asn Val Ala Lys Thr Leu Arg Pro Gln Glu 
            20                  25                  30          


Glu Lys Tyr Pro Val Gly Pro Trp Leu Leu Ala Leu Phe Val Phe Val 
        35                  40                  45              


Val Cys Gly Ser Ala Ile Phe Gln Ile Ile Gln Ser Ile Arg Met Gly 
    50                  55                  60                  


Met 
65  


<210>  576
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  576

Met Gly Pro Leu Ala Leu Pro Ala Trp Leu Gln Pro Arg Tyr Arg Lys 
1               5                   10                  15      


Asn Ala Tyr Leu Phe Ile Tyr Tyr Leu Ile Gln Phe Cys Gly His Ser 
            20                  25                  30          


Trp Ile Phe Thr Asn Met Thr Val Arg Phe Phe Ser Phe Gly Lys Asp 
        35                  40                  45              


Ser Met Val Asp Thr Phe Tyr Ala Ile Gly Leu Val Met Arg Leu Cys 
    50                  55                  60                  


Gln Ser Val Ser Leu Leu Glu Leu Leu His Ile Tyr Val Gly Ile Glu 
65                  70                  75                  80  


Ser Asn His Leu Leu Pro Arg Phe Leu Gln Leu Thr Glu Arg Ile Ile 
                85                  90                  95      


Ile Leu Phe Val Val Ile Thr Ser Gln Glu Glu Val Gln Glu Lys Tyr 
            100                 105                 110         


Val Val Cys Val Leu Phe Val Phe Trp Asn Leu Leu Asp Met Val Arg 
        115                 120                 125             


Tyr Thr Tyr Ser Met Leu Ser Val Ile Gly Ile Ser Tyr Ala Val Leu 
    130                 135                 140                 


Thr Trp Leu Ser Gln Thr Leu Trp Met Pro Ile Tyr Pro Leu Cys Val 
145                 150                 155                 160 


Leu Ala Glu Ala Phe Ala Ile Tyr Gln Ser Leu Pro Tyr Phe Glu Ser 
                165                 170                 175     


Phe Gly Thr Tyr Ser Thr Lys Leu Pro Phe Asp Leu Ser Ile Tyr Phe 
            180                 185                 190         


Pro Tyr Val Leu Lys Ile Tyr Leu Met Met Leu Phe Ile Gly Met Tyr 
        195                 200                 205             


Phe Thr Tyr Ser His Leu Tyr Ser Glu Arg Arg Asp Ile Leu Gly Ile 
    210                 215                 220                 


Phe Pro Ile Lys Lys Lys Lys Met 
225                 230         


<210>  577
<211>  315
<212>  PRT
<213>  Homo sapiens

<400>  577

Met Glu Lys Phe Arg Ala Val Leu Asp Leu His Val Lys His His Ser 
1               5                   10                  15      


Ala Leu Gly Tyr Gly Leu Val Thr Leu Leu Thr Ala Gly Gly Glu Arg 
            20                  25                  30          


Ile Phe Ser Ala Val Ala Phe Gln Cys Pro Cys Ser Ala Ala Trp Asn 
        35                  40                  45              


Leu Pro Tyr Gly Leu Val Phe Leu Leu Val Pro Ala Leu Ala Leu Phe 
    50                  55                  60                  


Leu Leu Gly Tyr Val Leu Ser Ala Arg Thr Trp Arg Leu Leu Thr Gly 
65                  70                  75                  80  


Cys Cys Ser Ser Ala Arg Ala Ser Cys Gly Ser Ala Leu Arg Gly Ser 
                85                  90                  95      


Leu Val Cys Thr Gln Ile Ser Ala Ala Ala Ala Leu Ala Pro Leu Thr 
            100                 105                 110         


Trp Val Ala Val Ala Leu Leu Gly Gly Ala Phe Tyr Glu Cys Ala Ala 
        115                 120                 125             


Thr Gly Ser Ala Ala Phe Ala Gln Arg Leu Cys Leu Gly Arg Asn Arg 
    130                 135                 140                 


Ser Cys Ala Ala Glu Leu Pro Leu Val Pro Cys Asn Gln Ala Lys Ala 
145                 150                 155                 160 


Ser Asp Val Gln Asp Leu Leu Lys Asp Leu Lys Ala Gln Ser Gln Val 
                165                 170                 175     


Leu Gly Trp Ile Leu Ile Ala Val Val Ile Ile Ile Leu Leu Ile Phe 
            180                 185                 190         


Thr Ser Val Thr Arg Cys Leu Ser Pro Val Ser Phe Leu Gln Leu Lys 
        195                 200                 205             


Phe Trp Lys Ile Tyr Leu Glu Gln Glu Gln Gln Ile Leu Lys Ser Lys 
    210                 215                 220                 


Ala Thr Glu His Ala Thr Glu Leu Ala Lys Glu Asn Ile Lys Cys Phe 
225                 230                 235                 240 


Phe Glu Gly Ser His Pro Lys Glu Tyr Asn Thr Pro Ser Met Lys Glu 
                245                 250                 255     


Trp Gln Gln Ile Ser Ser Leu Tyr Thr Phe Asn Pro Lys Gly Gln Tyr 
            260                 265                 270         


Tyr Ser Met Leu His Lys Tyr Val Asn Arg Lys Glu Lys Thr His Ser 
        275                 280                 285             


Ile Arg Ser Thr Glu Gly Asp Thr Val Ile Pro Val Leu Gly Phe Val 
    290                 295                 300                 


Asp Ser Ser Gly Ile Asn Ser Thr Pro Glu Leu 
305                 310                 315 


<210>  578
<211>  890
<212>  PRT
<213>  Homo sapiens

<400>  578

Met Ser Arg Ser Ala Thr Leu Leu Leu Cys Leu Leu Gly Cys His Val 
1               5                   10                  15      


Trp Lys Ala Val Thr Lys Thr Leu Arg Glu Pro Gly Ala Gly Ala Gln 
            20                  25                  30          


Glu Val Thr Leu Lys Val His Ile Ser Asp Ala Ser Thr His Gln Pro 
        35                  40                  45              


Val Ala Asp Ala Leu Ile Glu Ile Phe Thr Asn Gln Ala Ser Ile Ala 
    50                  55                  60                  


Ser Gly Thr Ser Gly Thr Asp Gly Val Ala Phe Ile Lys Phe Gln Tyr 
65                  70                  75                  80  


Lys Leu Gly Ser Gln Leu Ile Val Thr Ala Ser Lys His Ala Tyr Val 
                85                  90                  95      


Pro Asn Ser Ala Pro Trp Lys Pro Ile Arg Leu Pro Val Phe Ser Ser 
            100                 105                 110         


Leu Ser Leu Gly Leu Leu Pro Glu Arg Ser Ala Thr Leu Met Val Tyr 
        115                 120                 125             


Glu Asp Val Val Gln Ile Val Ser Gly Phe Gln Gly Ala Arg Pro Gln 
    130                 135                 140                 


Pro Arg Val His Phe Gln Arg Arg Ala Leu Arg Leu Pro Glu Asn Thr 
145                 150                 155                 160 


Ser Tyr Ser Asp Leu Thr Ala Phe Leu Thr Ala Ala Ser Ser Pro Ser 
                165                 170                 175     


Glu Val Asp Ser Phe Pro Tyr Leu Arg Gly Leu Asp Gly Asn Gly Thr 
            180                 185                 190         


Gly Asn Ser Thr Arg His Asp Leu Thr Pro Val Thr Ala Val Ser Val 
        195                 200                 205             


His Leu Leu Ser Ser Asn Gly Thr Pro Val Leu Val Asp Gly Pro Ile 
    210                 215                 220                 


Tyr Val Thr Val Pro Leu Ala Thr Gln Ser Ser Leu Arg His Asn Ala 
225                 230                 235                 240 


Tyr Val Ala Ala Trp Arg Phe Asp Gln Lys Leu Gly Thr Trp Leu Lys 
                245                 250                 255     


Ser Gly Leu Gly Leu Val His Gln Glu Gly Ser Gln Leu Thr Trp Thr 
            260                 265                 270         


Tyr Ile Ala Pro Gln Leu Gly Tyr Trp Val Ala Ala Met Ser Pro Pro 
        275                 280                 285             


Ile Pro Gly Pro Val Val Thr Gln Asp Ile Thr Thr Tyr His Thr Val 
    290                 295                 300                 


Phe Leu Leu Ala Ile Leu Gly Gly Met Ala Phe Ile Leu Leu Val Leu 
305                 310                 315                 320 


Leu Cys Leu Leu Leu Tyr Tyr Cys Arg Arg Lys Cys Leu Lys Pro Arg 
                325                 330                 335     


Gln His His Arg Lys Leu Gln Leu Pro Ala Gly Leu Glu Ser Ser Lys 
            340                 345                 350         


Arg Asp Gln Ser Thr Ser Met Ser His Ile Asn Leu Leu Phe Ser Arg 
        355                 360                 365             


Arg Ala Ser Glu Phe Pro Gly Pro Leu Ser Val Thr Ser His Gly Arg 
    370                 375                 380                 


Pro Glu Ala Pro Gly Thr Lys Glu Leu Met Ser Gly Val His Leu Glu 
385                 390                 395                 400 


Met Met Ser Pro Gly Gly Glu Gly Asp Leu His Thr Pro Met Leu Lys 
                405                 410                 415     


Leu Ser Tyr Ser Thr Ser Gln Glu Phe Ser Ser Arg Glu Glu Leu Leu 
            420                 425                 430         


Ser Cys Lys Glu Glu Asp Lys Ser Gln Ile Ser Phe Asp Asn Leu Thr 
        435                 440                 445             


Pro Ser Gly Thr Leu Gly Lys Asp Tyr His Lys Ser Val Glu Val Phe 
    450                 455                 460                 


Pro Leu Lys Ala Arg Lys Ser Met Glu Arg Glu Gly Tyr Glu Ser Ser 
465                 470                 475                 480 


Gly Asn Asp Asp Tyr Arg Gly Ser Tyr Asn Thr Val Leu Ser Gln Pro 
                485                 490                 495     


Leu Phe Glu Lys Gln Asp Arg Glu Gly Pro Ala Ser Thr Gly Ser Lys 
            500                 505                 510         


Leu Thr Ile Gln Glu His Leu Tyr Pro Ala Pro Ser Ser Pro Glu Lys 
        515                 520                 525             


Glu Gln Leu Leu Asp Arg Arg Pro Thr Glu Cys Met Met Ser Arg Ser 
    530                 535                 540                 


Val Asp His Leu Glu Arg Pro Thr Ser Phe Pro Arg Pro Gly Gln Leu 
545                 550                 555                 560 


Ile Cys Cys Ser Ser Val Asp Gln Val Asn Asp Ser Val Tyr Arg Lys 
                565                 570                 575     


Val Leu Pro Ala Leu Val Ile Pro Ala His Tyr Met Lys Leu Pro Gly 
            580                 585                 590         


Asp His Ser Tyr Val Ser Gln Pro Leu Val Val Pro Ala Asp Gln Gln 
        595                 600                 605             


Leu Glu Ile Glu Arg Leu Gln Ala Glu Leu Ser Asn Pro His Ala Gly 
    610                 615                 620                 


Ile Phe Pro His Pro Ser Ser Gln Ile Gln Pro Gln Pro Leu Ser Ser 
625                 630                 635                 640 


Gln Ala Ile Ser Gln Gln His Leu Gln Asp Ala Gly Thr Arg Glu Trp 
                645                 650                 655     


Ser Pro Gln Asn Ala Ser Met Ser Glu Ser Leu Ser Ile Pro Ala Ser 
            660                 665                 670         


Leu Asn Asp Ala Ala Leu Ala Gln Met Asn Ser Glu Val Gln Leu Leu 
        675                 680                 685             


Thr Glu Lys Ala Leu Met Glu Leu Gly Gly Gly Lys Pro Leu Pro His 
    690                 695                 700                 


Pro Arg Ala Trp Phe Val Ser Leu Asp Gly Arg Ser Asn Ala His Val 
705                 710                 715                 720 


Arg His Ser Tyr Ile Asp Leu Gln Arg Ala Gly Arg Asn Gly Ser Asn 
                725                 730                 735     


Asp Ala Ser Leu Asp Ser Gly Val Asp Met Asn Glu Pro Lys Ser Ala 
            740                 745                 750         


Arg Lys Gly Arg Gly Asp Ala Leu Ser Leu Gln Gln Asn Tyr Pro Pro 
        755                 760                 765             


Val Gln Glu His Gln Gln Lys Glu Pro Arg Ala Pro Asp Ser Thr Ala 
    770                 775                 780                 


Tyr Thr Gln Leu Val Tyr Leu Asp Asp Val Glu Gln Ser Gly Ser Glu 
785                 790                 795                 800 


Cys Gly Thr Thr Val Cys Thr Pro Glu Asp Ser Ala Leu Arg Cys Leu 
                805                 810                 815     


Leu Glu Gly Ser Ser Arg Arg Ser Gly Gly Gln Leu Pro Ser Leu Gln 
            820                 825                 830         


Glu Glu Thr Thr Arg Arg Thr Ala Asp Ala Pro Ser Glu Pro Ala Ala 
        835                 840                 845             


Ser Pro His Gln Arg Arg Ser Ala His Glu Glu Glu Glu Asp Asp Asp 
    850                 855                 860                 


Asp Asp Asp Gln Gly Glu Asp Lys Lys Ser Pro Trp Gln Lys Arg Glu 
865                 870                 875                 880 


Glu Arg Pro Leu Met Ala Phe Asn Ile Lys 
                885                 890 


<210>  579
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  579

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr 
                165                 170                 175     


Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser 
            180                 185                 190         


Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu 
        195                 200                 205             


Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp 
    210                 215                 220                 


His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro 
225                 230                 235                 240 


His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp 
                245                 250                 255     


Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr 
            260                 265                 270         


Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys 
        275                 280                 285             


Glu Thr 
    290 


<210>  580
<211>  723
<212>  PRT
<213>  Homo sapiens

<400>  580

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr Cys Arg Asn Pro Arg 
                165                 170                 175     


Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser Asn Pro Glu Val Arg 
            180                 185                 190         


Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu Val Glu Cys Met Thr 
        195                 200                 205             


Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp His Thr Glu Ser Gly 
    210                 215                 220                 


Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro His Arg His Lys Phe 
225                 230                 235                 240 


Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp Asp Asn Tyr Cys Arg 
                245                 250                 255     


Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr Thr Leu Asp Pro His 
            260                 265                 270         


Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys Ala Asp Asn Thr Met 
        275                 280                 285             


Asn Asp Thr Asp Val Pro Leu Glu Thr Thr Glu Cys Ile Gln Gly Gln 
    290                 295                 300                 


Gly Glu Gly Tyr Arg Gly Thr Val Asn Thr Ile Trp Asn Gly Ile Pro 
305                 310                 315                 320 


Cys Gln Arg Trp Asp Ser Gln Tyr Pro His Glu His Asp Met Thr Pro 
                325                 330                 335     


Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu Asn Tyr Cys Arg Asn Pro 
            340                 345                 350         


Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr Thr Asp Pro Asn Ile Arg 
        355                 360                 365             


Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys Asp Met Ser His Gly Gln 
    370                 375                 380                 


Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr Met Gly Asn Leu Ser Gln 
385                 390                 395                 400 


Thr Arg Ser Gly Leu Thr Cys Ser Met Trp Asp Lys Asn Met Glu Asp 
                405                 410                 415     


Leu His Arg His Ile Phe Trp Glu Pro Asp Ala Ser Lys Leu Asn Glu 
            420                 425                 430         


Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala His Gly Pro Trp Cys Tyr 
        435                 440                 445             


Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr Cys Pro Ile Ser Arg Cys 
    450                 455                 460                 


Glu Gly Asp Thr Thr Pro Thr Ile Val Asn Leu Asp His Pro Val Ile 
465                 470                 475                 480 


Ser Cys Ala Lys Thr Lys Gln Leu Arg Val Val Asn Gly Ile Pro Thr 
                485                 490                 495     


Arg Thr Asn Ile Gly Trp Met Val Ser Leu Arg Tyr Arg Asn Lys His 
            500                 505                 510         


Ile Cys Gly Gly Ser Leu Ile Lys Glu Ser Trp Val Leu Thr Ala Arg 
        515                 520                 525             


Gln Cys Phe Pro Ser Arg Asp Leu Lys Asp Tyr Glu Ala Trp Leu Gly 
    530                 535                 540                 


Ile His Asp Val His Gly Arg Gly Asp Glu Lys Cys Lys Gln Val Leu 
545                 550                 555                 560 


Asn Val Ser Gln Leu Val Tyr Gly Pro Glu Gly Ser Asp Leu Val Leu 
                565                 570                 575     


Met Lys Leu Ala Arg Pro Ala Val Leu Asp Asp Phe Val Ser Thr Ile 
            580                 585                 590         


Asp Leu Pro Asn Tyr Gly Cys Thr Ile Pro Glu Lys Thr Ser Cys Ser 
        595                 600                 605             


Val Tyr Gly Trp Gly Tyr Thr Gly Leu Ile Asn Tyr Asp Gly Leu Leu 
    610                 615                 620                 


Arg Val Ala His Leu Tyr Ile Met Gly Asn Glu Lys Cys Ser Gln His 
625                 630                 635                 640 


His Arg Gly Lys Val Thr Leu Asn Glu Ser Glu Ile Cys Ala Gly Ala 
                645                 650                 655     


Glu Lys Ile Gly Ser Gly Pro Cys Glu Gly Asp Tyr Gly Gly Pro Leu 
            660                 665                 670         


Val Cys Glu Gln His Lys Met Arg Met Val Leu Gly Val Ile Val Pro 
        675                 680                 685             


Gly Arg Gly Cys Ala Ile Pro Asn Arg Pro Gly Ile Phe Val Arg Val 
    690                 695                 700                 


Ala Tyr Tyr Ala Lys Trp Ile His Lys Ile Ile Leu Thr Tyr Lys Val 
705                 710                 715                 720 


Pro Gln Ser 
            


<210>  581
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  581

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr Cys Arg Asn Pro Arg 
                165                 170                 175     


Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser Asn Pro Glu Val Arg 
            180                 185                 190         


Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu Val Glu Cys Met Thr 
        195                 200                 205             


Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp His Thr Glu Ser Gly 
    210                 215                 220                 


Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro His Arg His Lys Phe 
225                 230                 235                 240 


Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp Asp Asn Tyr Cys Arg 
                245                 250                 255     


Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr Thr Leu Asp Pro His 
            260                 265                 270         


Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys Glu Thr 
        275                 280                 285 


<210>  582
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  582

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr 
                165                 170                 175     


Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser 
            180                 185                 190         


Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu 
        195                 200                 205             


Gly Lys 
    210 


<210>  583
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  583

Met Ser Phe Arg Lys Val Asn Ile Ile Ile Leu Val Leu Ala Val Ala 
1               5                   10                  15      


Leu Phe Leu Leu Val Leu His His Asn Phe Leu Ser Leu Ser Ser Leu 
            20                  25                  30          


Leu Arg Asn Glu Val Thr Asp Ser Gly Ile Val Gly Pro Gln Pro Ile 
        35                  40                  45              


Asp Phe Val Pro Asn Ala Leu Arg His Ala Val Asp Gly Arg Gln Glu 
    50                  55                  60                  


Glu Ile Pro Val Val Ile Ala Ala Ser Glu Asp Arg Leu Gly Gly Ala 
65                  70                  75                  80  


Ile Ala Ala Ile Asn Ser Ile Gln His Asn Thr Arg Ser Asn Val Ile 
                85                  90                  95      


Phe Tyr Ile Val Thr Leu Asn Asn Thr Ala Asp His Leu Arg Ser Trp 
            100                 105                 110         


Leu Asn Ser Asp Ser Leu Lys Ser Ile Arg Tyr Lys Ile Val Asn Phe 
        115                 120                 125             


Asp Pro Lys Leu Leu Glu Gly Lys Val Lys Glu Asp Pro Asp Gln Gly 
    130                 135                 140                 


Glu Ser Met Lys Pro Leu Thr Phe Ala Arg Phe Tyr Leu Pro Ile Leu 
145                 150                 155                 160 


Val Pro Ser Ala Lys Lys Ala Ile Tyr Met Asp Asp Asp Val Ile Val 
                165                 170                 175     


Gln Gly Asp Ile Leu Ala Leu Tyr Asn Thr Ala Leu Lys Pro Gly His 
            180                 185                 190         


Ala Ala Ala Phe Ser Glu Asp Cys Asp Ser Ala Ser Thr Lys Val Val 
        195                 200                 205             


Ile Arg Gly Ala Gly Asn Gln Tyr Asn Tyr Ile Gly Tyr Leu Asp Tyr 
    210                 215                 220                 


Lys Lys Glu Arg Ile Arg Lys Leu Ser Met Lys Ala Ser Thr Cys Ser 
225                 230                 235                 240 


Phe Asn Pro Gly Val Phe Val Ala Asn Leu Thr Glu Trp Lys Arg Gln 
                245                 250                 255     


Asn Ile Thr Asn Gln Leu Glu Lys Trp Met Lys Leu Asn Val Glu Glu 
            260                 265                 270         


Gly Leu Tyr Ser Arg Thr Leu Ala Gly Ser Ile Thr Thr Pro Pro Leu 
        275                 280                 285             


Leu Ile Val Phe Tyr Gln Gln His Ser Thr Ile Asp Pro Met Trp Asn 
    290                 295                 300                 


Val Arg His Leu Gly Ser Ser Ala Gly Lys Arg Tyr Ser Pro Gln Phe 
305                 310                 315                 320 


Val Lys Ala Ala Lys Leu Leu His Trp Asn Gly His Leu Lys Pro Trp 
                325                 330                 335     


Gly Arg Thr Ala Ser Tyr Thr Asp Val Trp Glu Lys Trp Tyr Ile Pro 
            340                 345                 350         


Asp Pro Thr Gly Lys Phe Asn Leu Ile Arg Arg Tyr Thr Glu Ile Ser 
        355                 360                 365             


Asn Ile Lys 
    370     


<210>  584
<211>  1119
<212>  PRT
<213>  Homo sapiens

<400>  584

Met Gln Met Val Pro Ser Leu Pro Pro Ala Ser Glu Cys Ala Gly Glu 
1               5                   10                  15      


Glu Lys Arg Val Gly Thr Arg Thr Val Phe Val Gly Asn His Pro Val 
            20                  25                  30          


Ser Glu Thr Glu Ala Tyr Ile Ala Gln Arg Phe Cys Asp Asn Arg Ile 
        35                  40                  45              


Val Ser Ser Lys Tyr Thr Leu Trp Asn Phe Leu Pro Lys Asn Leu Phe 
    50                  55                  60                  


Glu Gln Phe Arg Arg Ile Ala Asn Phe Tyr Phe Leu Ile Ile Phe Leu 
65                  70                  75                  80  


Val Gln Val Thr Val Asp Thr Pro Thr Ser Pro Val Thr Ser Gly Leu 
                85                  90                  95      


Pro Leu Phe Phe Val Ile Thr Val Thr Ala Ile Lys Gln Gly Tyr Glu 
            100                 105                 110         


Asp Trp Leu Arg His Arg Ala Asp Asn Glu Val Asn Lys Ser Thr Val 
        115                 120                 125             


Tyr Ile Ile Glu Asn Ala Lys Arg Val Arg Lys Glu Ser Glu Lys Ile 
    130                 135                 140                 


Lys Val Gly Asp Val Val Glu Val Gln Ala Asp Glu Thr Phe Pro Cys 
145                 150                 155                 160 


Asp Leu Ile Leu Leu Ser Ser Cys Thr Thr Asp Gly Thr Cys Tyr Val 
                165                 170                 175     


Thr Thr Ala Ser Leu Asp Gly Glu Ser Asn Cys Lys Thr His Tyr Ala 
            180                 185                 190         


Val Arg Asp Thr Ile Ala Leu Cys Thr Ala Glu Ser Ile Asp Thr Leu 
        195                 200                 205             


Arg Ala Ala Ile Glu Cys Glu Gln Pro Gln Pro Asp Leu Tyr Lys Phe 
    210                 215                 220                 


Val Gly Arg Ile Asn Ile Tyr Ser Asn Ser Leu Glu Ala Val Ala Arg 
225                 230                 235                 240 


Ser Leu Gly Pro Glu Asn Leu Leu Leu Lys Gly Ala Thr Leu Lys Asn 
                245                 250                 255     


Thr Glu Lys Ile Tyr Gly Val Ala Val Tyr Thr Gly Met Glu Thr Lys 
            260                 265                 270         


Met Ala Leu Asn Tyr Gln Gly Lys Ser Gln Lys Arg Ser Ala Val Glu 
        275                 280                 285             


Lys Ser Ile Asn Ala Phe Leu Ile Val Tyr Leu Phe Ile Leu Leu Thr 
    290                 295                 300                 


Lys Ala Ala Val Cys Thr Thr Leu Lys Tyr Val Trp Gln Ser Thr Pro 
305                 310                 315                 320 


Tyr Asn Asp Glu Pro Trp Tyr Asn Gln Lys Thr Gln Lys Glu Arg Glu 
                325                 330                 335     


Thr Leu Lys Val Leu Lys Met Phe Thr Asp Phe Leu Ser Phe Met Val 
            340                 345                 350         


Leu Phe Asn Phe Ile Ile Pro Val Ser Met Tyr Val Thr Val Glu Met 
        355                 360                 365             


Gln Lys Phe Leu Gly Ser Phe Phe Ile Ser Trp Asp Lys Asp Phe Tyr 
    370                 375                 380                 


Asp Glu Glu Ile Asn Glu Gly Ala Leu Val Asn Thr Ser Asp Leu Asn 
385                 390                 395                 400 


Glu Glu Leu Gly Gln Val Asp Tyr Val Phe Thr Asp Lys Thr Gly Thr 
                405                 410                 415     


Leu Thr Glu Asn Ser Met Glu Phe Ile Glu Cys Cys Ile Asp Gly His 
            420                 425                 430         


Lys Tyr Lys Gly Val Thr Gln Glu Val Asp Gly Leu Ser Gln Thr Asp 
        435                 440                 445             


Gly Thr Leu Thr Tyr Phe Asp Lys Val Asp Lys Asn Arg Glu Glu Leu 
    450                 455                 460                 


Phe Leu Arg Ala Leu Cys Leu Cys His Thr Val Glu Ile Lys Thr Asn 
465                 470                 475                 480 


Asp Ala Val Asp Gly Ala Thr Glu Ser Ala Glu Leu Thr Tyr Ile Ser 
                485                 490                 495     


Ser Ser Pro Asp Glu Ile Ala Leu Val Lys Gly Ala Lys Arg Tyr Gly 
            500                 505                 510         


Phe Thr Phe Leu Gly Asn Arg Asn Gly Tyr Met Arg Val Glu Asn Gln 
        515                 520                 525             


Arg Lys Glu Ile Glu Glu Tyr Glu Leu Leu His Thr Leu Asn Phe Asp 
    530                 535                 540                 


Ala Val Arg Arg Arg Met Ser Val Ile Val Lys Thr Gln Glu Gly Asp 
545                 550                 555                 560 


Ile Leu Leu Phe Cys Lys Gly Ala Asp Ser Ala Val Phe Pro Arg Val 
                565                 570                 575     


Gln Asn His Glu Ile Glu Leu Thr Lys Val His Val Glu Arg Asn Ala 
            580                 585                 590         


Met Asp Gly Tyr Arg Thr Leu Cys Val Ala Phe Lys Glu Ile Ala Pro 
        595                 600                 605             


Asp Asp Tyr Glu Arg Ile Asn Arg Gln Leu Ile Glu Ala Lys Met Ala 
    610                 615                 620                 


Leu Gln Asp Arg Glu Glu Lys Met Glu Lys Val Phe Asp Asp Ile Glu 
625                 630                 635                 640 


Thr Asn Met Asn Leu Ile Gly Ala Thr Ala Val Glu Asp Lys Leu Gln 
                645                 650                 655     


Asp Gln Ala Ala Glu Thr Ile Glu Ala Leu His Ala Ala Gly Leu Lys 
            660                 665                 670         


Val Trp Val Leu Thr Gly Asp Lys Met Glu Thr Ala Lys Ser Thr Cys 
        675                 680                 685             


Tyr Ala Cys Arg Leu Phe Gln Thr Asn Thr Glu Leu Leu Glu Leu Thr 
    690                 695                 700                 


Thr Lys Thr Ile Glu Glu Ser Glu Arg Lys Glu Asp Arg Leu His Glu 
705                 710                 715                 720 


Leu Leu Ile Glu Tyr Arg Lys Lys Leu Leu His Glu Phe Pro Lys Ser 
                725                 730                 735     


Thr Arg Ser Phe Lys Lys Ala Trp Thr Glu His Gln Glu Tyr Gly Leu 
            740                 745                 750         


Ile Ile Asp Gly Ser Thr Leu Ser Leu Ile Leu Asn Ser Ser Gln Asp 
        755                 760                 765             


Ser Ser Ser Asn Asn Tyr Lys Ser Ile Phe Leu Gln Ile Cys Met Lys 
    770                 775                 780                 


Cys Thr Ala Val Leu Cys Cys Arg Met Ala Pro Leu Gln Lys Ala Gln 
785                 790                 795                 800 


Ile Val Arg Met Val Lys Asn Leu Lys Gly Ser Pro Ile Thr Leu Ser 
                805                 810                 815     


Ile Gly Asp Gly Ala Asn Asp Val Ser Met Ile Leu Glu Ser His Val 
            820                 825                 830         


Gly Ile Gly Ile Lys Gly Lys Glu Gly Arg Gln Ala Ala Arg Asn Ser 
        835                 840                 845             


Asp Tyr Ser Val Pro Lys Phe Lys His Leu Lys Lys Leu Leu Leu Ala 
    850                 855                 860                 


His Gly His Leu Tyr Tyr Val Arg Ile Ala His Leu Val Gln Tyr Phe 
865                 870                 875                 880 


Phe Tyr Lys Asn Leu Cys Phe Ile Leu Pro Gln Phe Leu Tyr Gln Phe 
                885                 890                 895     


Phe Cys Gly Phe Ser Gln Gln Pro Leu Tyr Asp Ala Ala Tyr Leu Thr 
            900                 905                 910         


Met Tyr Asn Ile Cys Phe Thr Ser Leu Pro Ile Leu Ala Tyr Ser Leu 
        915                 920                 925             


Leu Glu Gln His Ile Asn Ile Asp Thr Leu Thr Ser Asp Pro Arg Leu 
    930                 935                 940                 


Tyr Met Lys Ile Ser Gly Asn Ala Met Leu Gln Leu Gly Pro Phe Leu 
945                 950                 955                 960 


Tyr Trp Thr Phe Leu Ala Ala Phe Glu Gly Thr Val Phe Phe Phe Gly 
                965                 970                 975     


Thr Tyr Phe Leu Phe Gln Thr Ala Ser Leu Glu Glu Asn Gly Lys Val 
            980                 985                 990         


Tyr Gly Asn Trp Thr Phe Gly Thr  Ile Val Phe Thr Val  Leu Val Phe 
        995                 1000                 1005             


Thr Val  Thr Leu Lys Leu Ala  Leu Asp Thr Arg Phe  Trp Thr Trp 
    1010                 1015                 1020             


Ile Asn  His Phe Val Ile Trp  Gly Ser Leu Ala Phe  Tyr Val Phe 
    1025                 1030                 1035             


Phe Ser  Phe Phe Trp Gly Gly  Ile Ile Trp Pro Phe  Leu Lys Gln 
    1040                 1045                 1050             


Gln Arg  Met Tyr Phe Val Phe  Ala Gln Met Leu Ser  Ser Val Ser 
    1055                 1060                 1065             


Thr Trp  Leu Ala Ile Ile Leu  Leu Ile Phe Ile Ser  Leu Phe Pro 
    1070                 1075                 1080             


Glu Ile  Leu Leu Ile Val Leu  Lys Asn Val Arg Arg  Arg Ser Ala 
    1085                 1090                 1095             


Arg Asn  Pro Asn Leu Glu Leu  Pro Met Leu Leu Ser  Tyr Lys His 
    1100                 1105                 1110             


Thr Asp  Ser Gly Tyr Ser 
    1115                 


<210>  585
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  585

Met Glu Ser Glu Thr Glu Pro Glu Pro Val Thr Leu Leu Val Lys Ser 
1               5                   10                  15      


Pro Asn Gln Arg His Arg Asp Leu Glu Leu Ser Gly Asp Arg Gly Trp 
            20                  25                  30          


Ser Val Gly His Leu Lys Ala His Leu Ser Arg Val Tyr Pro Glu Arg 
        35                  40                  45              


Pro Arg Pro Glu Asp Gln Arg Leu Ile Tyr Ser Gly Lys Leu Leu Leu 
    50                  55                  60                  


Asp His Gln Cys Leu Arg Asp Leu Leu Pro Lys Glu Lys Arg His Val 
65                  70                  75                  80  


Leu His Leu Val Cys Asn Val Lys Ser Pro Ser Lys Met Pro Glu Ile 
                85                  90                  95      


Asn Ala Lys Val Ala Glu Ser Thr Glu Glu Pro Ala Gly Ser Asn Arg 
            100                 105                 110         


Gly Gln Tyr Pro Glu Asp Ser Ser Ser Asp Gly Leu Arg Gln Arg Glu 
        115                 120                 125             


Val Leu Arg Asn Leu Ser Ser Pro Gly Trp Glu Asn Ile Ser Arg Pro 
    130                 135                 140                 


Glu Ala Ala Gln Gln Ala Phe Gln Gly Leu Gly Pro Gly Phe Ser Gly 
145                 150                 155                 160 


Tyr Thr Pro Tyr Gly Trp Leu Gln Leu Ser Trp Phe Gln Gln Ile Tyr 
                165                 170                 175     


Ala Arg Gln Tyr Tyr Met Gln Tyr Leu Ala Ala Thr Ala Ala Ser Gly 
            180                 185                 190         


Ala Phe Val Pro Pro Pro Ser Ala Gln Glu Ile Pro Val Val Ser Ala 
        195                 200                 205             


Pro Ala Pro Ala Pro Ile His Asn Gln Phe Pro Ala Glu Asn Gln Pro 
    210                 215                 220                 


Ala Asn Gln Asn Ala Ala Pro Gln Val Val Val Asn Pro Gly Ala Asn 
225                 230                 235                 240 


Gln Asn Leu Arg Met Asn Ala Gln Gly Gly Pro Ile Val Glu Glu Asp 
                245                 250                 255     


Asp Glu Ile Asn Arg Asp Trp Leu Asp Trp Thr Tyr Ser Ala Ala Thr 
            260                 265                 270         


Phe Ser Val Phe Leu Ser Ile Leu Tyr Phe Tyr Ser Ser Leu Ser Arg 
        275                 280                 285             


Phe Leu Met Val Met Gly Ala Thr Val Val Met Tyr Leu His His Val 
    290                 295                 300                 


Gly Trp Phe Pro Phe Arg Pro Arg Pro Val Gln Asn Phe Pro Asn Asp 
305                 310                 315                 320 


Gly Pro Pro Pro Asp Val Val Asn Gln Asp Pro Asn Asn Asn Leu Gln 
                325                 330                 335     


Glu Gly Thr Asp Pro Glu Thr Glu Asp Pro Asn His Leu Pro Pro Asp 
            340                 345                 350         


Arg Asp Val Leu Asp Gly Glu Gln Thr Ser Pro Ser Phe Met Ser Thr 
        355                 360                 365             


Ala Trp Leu Val Phe Lys Thr Phe Phe Ala Ser Leu Leu Pro Glu Gly 
    370                 375                 380                 


Pro Pro Ala Ile Ala Asn 
385                 390 


<210>  586
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  586

Met Glu Ser Glu Thr Glu Pro Glu Pro Val Thr Leu Leu Val Lys Ser 
1               5                   10                  15      


Pro Asn Gln Arg His Arg Asp Leu Glu Leu Ser Gly Asp Arg Gly Trp 
            20                  25                  30          


Ser Val Gly His Leu Lys Ala His Leu Ser Arg Val Tyr Pro Glu Arg 
        35                  40                  45              


Pro Arg Pro Glu Asp Gln Arg Leu Ile Tyr Ser Gly Lys Leu Leu Leu 
    50                  55                  60                  


Asp His Gln Cys Leu Arg Asp Leu Leu Pro Lys Glu Lys Arg His Val 
65                  70                  75                  80  


Leu His Leu Val Cys Asn Val Lys Ser Pro Ser Lys Met Pro Glu Ile 
                85                  90                  95      


Asn Ala Lys Val Ala Glu Ser Thr Glu Glu Pro Ala Gly Ser Asn Arg 
            100                 105                 110         


Gly Gln Tyr Pro Glu Asp Ser Ser Ser Asp Gly Leu Arg Gln Arg Glu 
        115                 120                 125             


Val Leu Arg Asn Leu Ser Ser Pro Gly Trp Glu Asn Ile Ser Arg Pro 
    130                 135                 140                 


Glu Ala Ala Gln Gln Ala Phe Gln Gly Leu Gly Pro Gly Phe Ser Gly 
145                 150                 155                 160 


Tyr Thr Pro Tyr Gly Trp Leu Gln Leu Ser Trp Phe Gln Gln Ile Tyr 
                165                 170                 175     


Ala Arg Gln Tyr Tyr Met Gln Tyr Leu Ala Ala Thr Ala Ala Ser Gly 
            180                 185                 190         


Ala Phe Val Pro Pro Pro Ser Ala Gln Glu Ile Pro Val Val Ser Ala 
        195                 200                 205             


Pro Ala Pro Ala Pro Ile His Asn Gln Phe Pro Ala Glu Asn Gln Pro 
    210                 215                 220                 


Ala Asn Gln Asn Ala Ala Pro Gln Val Val Val Asn Pro Gly Ala Asn 
225                 230                 235                 240 


Gln Asn Leu Arg Met Asn Ala Gln Gly Gly Pro Ile Val Glu Glu Asp 
                245                 250                 255     


Asp Glu Ile Asn Arg Asp Trp Leu Asp Trp Thr Tyr Ser Ala Ala Thr 
            260                 265                 270         


Phe Ser Val Phe Leu Ser Ile Leu Tyr Phe Tyr Ser Ser Leu Ser Arg 
        275                 280                 285             


Phe Leu Met Val Met Gly Ala Thr Val Val Met Tyr Leu His His Val 
    290                 295                 300                 


Gly Trp Phe Pro Phe Arg Pro Arg Pro Val Gln Asn Phe Pro Asn Asp 
305                 310                 315                 320 


Gly Pro Pro Pro Asp Val Val Asn Gln Asp Pro Asn Asn Asn Leu Gln 
                325                 330                 335     


Glu Gly Thr Asp Pro Glu Thr Glu Asp Pro Asn His Leu Pro Pro Asp 
            340                 345                 350         


Arg Asp Val Leu Asp Gly Glu Gln Thr Ser Pro Ser Phe Met Ser Thr 
        355                 360                 365             


Ala Trp Leu Val Phe Lys Thr Phe Phe Ala Ser Leu Leu Pro Glu Gly 
    370                 375                 380                 


Pro Pro Ala Ile Ala Asn 
385                 390 


<210>  587
<211>  681
<212>  PRT
<213>  Homo sapiens

<400>  587

Met Ser Lys Glu Leu Ala Ala Met Gly Pro Gly Ala Ser Gly Asp Gly 
1               5                   10                  15      


Val Arg Thr Glu Thr Ala Pro His Ile Ala Leu Asp Ser Arg Val Gly 
            20                  25                  30          


Leu His Ala Tyr Asp Ile Ser Val Val Val Ile Tyr Phe Val Phe Val 
        35                  40                  45              


Ile Ala Val Gly Ile Trp Ser Ser Ile Arg Ala Ser Arg Gly Thr Ile 
    50                  55                  60                  


Gly Gly Tyr Phe Leu Ala Gly Arg Ser Met Ser Trp Trp Pro Ile Gly 
65                  70                  75                  80  


Ala Ser Leu Met Ser Ser Asn Val Gly Ser Gly Leu Phe Ile Gly Leu 
                85                  90                  95      


Ala Gly Thr Gly Ala Ala Gly Gly Leu Ala Val Gly Gly Phe Glu Trp 
            100                 105                 110         


Asn Ala Thr Trp Leu Leu Leu Ala Leu Gly Trp Val Phe Val Pro Val 
        115                 120                 125             


Tyr Ile Ala Ala Gly Val Val Thr Met Pro Gln Tyr Leu Lys Lys Arg 
    130                 135                 140                 


Phe Gly Gly Gln Arg Ile Gln Val Tyr Met Ser Val Leu Ser Leu Ile 
145                 150                 155                 160 


Leu Tyr Ile Phe Thr Lys Ile Ser Thr Asp Ile Phe Ser Gly Ala Leu 
                165                 170                 175     


Phe Ile Gln Met Ala Leu Gly Trp Asn Leu Tyr Leu Ser Thr Gly Ile 
            180                 185                 190         


Leu Leu Val Val Thr Ala Val Tyr Thr Ile Ala Gly Gly Leu Met Ala 
        195                 200                 205             


Val Ile Tyr Thr Asp Ala Leu Gln Thr Val Ile Met Val Gly Gly Ala 
    210                 215                 220                 


Leu Val Leu Met Phe Leu Gly Phe Gln Asp Val Gly Trp Tyr Pro Gly 
225                 230                 235                 240 


Leu Glu Gln Arg Tyr Arg Gln Ala Ile Pro Asn Val Thr Val Pro Asn 
                245                 250                 255     


Thr Thr Cys His Leu Pro Arg Pro Asp Ala Phe His Ile Leu Arg Asp 
            260                 265                 270         


Pro Val Ser Gly Asp Ile Pro Trp Pro Gly Leu Ile Phe Gly Leu Thr 
        275                 280                 285             


Val Leu Ala Thr Trp Cys Trp Cys Thr Asp Gln Val Ile Val Gln Arg 
    290                 295                 300                 


Ser Leu Ser Ala Lys Ser Leu Ser His Ala Lys Gly Gly Ser Val Leu 
305                 310                 315                 320 


Gly Gly Tyr Leu Lys Ile Leu Pro Met Phe Phe Ile Val Met Pro Gly 
                325                 330                 335     


Met Ile Ser Arg Ala Leu Phe Pro Asp Glu Val Gly Cys Val Asp Pro 
            340                 345                 350         


Asp Val Cys Gln Arg Ile Cys Gly Ala Arg Val Gly Cys Ser Asn Ile 
        355                 360                 365             


Ala Tyr Pro Lys Leu Val Met Ala Leu Met Pro Val Gly Leu Arg Gly 
    370                 375                 380                 


Leu Met Ile Ala Val Ile Met Ala Ala Leu Met Ser Ser Leu Thr Ser 
385                 390                 395                 400 


Ile Phe Asn Ser Ser Ser Thr Leu Phe Thr Ile Asp Val Trp Gln Arg 
                405                 410                 415     


Phe Arg Arg Lys Ser Thr Glu Gln Glu Leu Met Val Val Gly Arg Val 
            420                 425                 430         


Phe Val Val Phe Leu Val Val Ile Ser Ile Leu Trp Ile Pro Ile Ile 
        435                 440                 445             


Gln Ser Ser Asn Ser Gly Gln Leu Phe Asp Tyr Ile Gln Ala Val Thr 
    450                 455                 460                 


Ser Tyr Leu Ala Pro Pro Ile Thr Ala Leu Phe Leu Leu Ala Ile Phe 
465                 470                 475                 480 


Cys Lys Arg Val Thr Glu Pro Gly Ala Phe Trp Gly Leu Val Phe Gly 
                485                 490                 495     


Leu Gly Val Gly Leu Leu Arg Met Ile Leu Glu Phe Ser Tyr Pro Ala 
            500                 505                 510         


Pro Ala Cys Gly Glu Val Asp Arg Arg Pro Ala Val Leu Lys Asp Phe 
        515                 520                 525             


His Tyr Leu Tyr Phe Ala Ile Leu Leu Cys Gly Leu Thr Ala Ile Val 
    530                 535                 540                 


Ile Val Ile Val Ser Leu Cys Thr Thr Pro Ile Pro Glu Glu Gln Leu 
545                 550                 555                 560 


Thr Arg Leu Thr Trp Trp Thr Arg Asn Cys Pro Leu Ser Glu Leu Glu 
                565                 570                 575     


Lys Glu Ala His Glu Ser Thr Pro Glu Ile Ser Glu Arg Pro Ala Gly 
            580                 585                 590         


Glu Cys Pro Ala Gly Gly Gly Ala Ala Glu Asn Ser Ser Leu Gly Gln 
        595                 600                 605             


Glu Gln Pro Glu Ala Pro Ser Arg Ser Trp Gly Lys Leu Leu Trp Ser 
    610                 615                 620                 


Trp Phe Cys Gly Leu Ser Gly Thr Pro Glu Gln Ala Leu Ser Pro Ala 
625                 630                 635                 640 


Glu Lys Ala Ala Leu Glu Gln Lys Leu Thr Ser Ile Glu Glu Glu Pro 
                645                 650                 655     


Leu Trp Arg His Val Cys Asn Ile Asn Ala Val Leu Leu Leu Ala Ile 
            660                 665                 670         


Asn Ile Phe Leu Trp Gly Tyr Phe Ala 
        675                 680     


<210>  588
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  588

Met Leu Ser Glu Ser Ser Ser Phe Leu Lys Gly Val Met Leu Gly Ser 
1               5                   10                  15      


Ile Phe Cys Ala Leu Ile Thr Met Leu Gly His Ile Arg Ile Gly His 
            20                  25                  30          


Gly Asn Arg Met His His His Glu His His His Leu Gln Ala Pro Asn 
        35                  40                  45              


Lys Glu Asp Ile Leu Lys Ile Ser Glu Asp Glu Arg Met Glu Leu Ser 
    50                  55                  60                  


Lys Ser Phe Arg Val Tyr Cys Ile Ile Leu Val Lys Pro Lys Asp Val 
65                  70                  75                  80  


Ser Leu Trp Ala Ala Val Lys Glu Thr Trp Thr Lys His Cys Asp Lys 
                85                  90                  95      


Ala Glu Phe Phe Ser Ser Glu Asn Val Lys Val Phe Glu Ser Ile Asn 
            100                 105                 110         


Met Asp Thr Asn Asp Met Trp Leu Met Met Arg Lys Ala Tyr Lys Tyr 
        115                 120                 125             


Ala Phe Asp Lys Tyr Arg Asp Gln Tyr Asn Trp Phe Phe Leu Ala Arg 
    130                 135                 140                 


Pro Thr Thr Phe Ala Ile Ile Glu Asn Leu Lys Tyr Phe Leu Leu Lys 
145                 150                 155                 160 


Lys Asp Pro Ser Gln Pro Phe Tyr Leu Gly His Thr Ile Lys Ser Gly 
                165                 170                 175     


Asp Leu Glu Tyr Val Gly Met Glu Gly Gly Ile Val Leu Ser Val Glu 
            180                 185                 190         


Ser Met Lys Arg Leu Asn Ser Leu Leu Asn Ile Pro Glu Lys Cys Pro 
        195                 200                 205             


Glu Gln Gly Gly Met Ile Trp Lys Ile Ser Glu Asp Lys Gln Leu Ala 
    210                 215                 220                 


Val Cys Leu Lys Tyr Ala Gly Val Phe Ala Glu Asn Ala Glu Asp Ala 
225                 230                 235                 240 


Asp Gly Lys Asp Val Phe Asn Thr Lys Ser Val Gly Leu Ser Ile Lys 
                245                 250                 255     


Glu Ala Met Thr Tyr His Pro Asn Gln Val Val Glu Gly Cys Cys Ser 
            260                 265                 270         


Asp Met Ala Val Thr Phe Asn Gly Leu Thr Pro Asn Gln Met His Val 
        275                 280                 285             


Met Met Tyr Gly Val Tyr Arg Leu Arg Ala Phe Gly His Ile Phe Asn 
    290                 295                 300                 


Asp Ala Leu Val Phe Leu Pro Pro Asn Gly Ser Asp Asn Asp 
305                 310                 315             


<210>  589
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  589

Met Ala Val Tyr Trp Cys Thr Glu Ala Leu Pro Leu Ser Val Thr Ala 
1               5                   10                  15      


Leu Leu Pro Ile Val Leu Phe Pro Phe Met Gly Ile Leu Pro Ser Asn 
            20                  25                  30          


Lys Val Cys Pro Gln Tyr Phe Leu Asp Thr Asn Phe Leu Phe Leu Ser 
        35                  40                  45              


Gly Leu Ile Met Ala Ser Ala Ile Glu Glu Trp Asn Leu His Arg Arg 
    50                  55                  60                  


Ile Ala Leu Lys Ile Leu Met Leu Val Gly Val Gln Pro Ala Arg Leu 
65                  70                  75                  80  


Ile Leu Gly Met Met Val Thr Thr Ser Phe Leu Ser Met Trp Leu Ser 
                85                  90                  95      


Asn Thr Ala Ser Thr Ala Met Met Leu Pro Ile Ala Asn Ala Ile Leu 
            100                 105                 110         


Lys Ser Leu Phe Gly Gln Lys Glu Val Arg Lys Asp Pro Ser Gln Glu 
        115                 120                 125             


Ser Glu Glu Asn Thr Ala Ala Val Arg Arg Asn Gly Leu His Thr Val 
    130                 135                 140                 


Pro Thr Glu Met Gln Phe Leu Ala Ser Thr Glu Ala Lys Asp His Pro 
145                 150                 155                 160 


Gly Glu Thr Glu Val Pro Leu Asp Leu Pro Ala Asp Ser Arg Lys Glu 
                165                 170                 175     


Asp Glu Tyr Arg Arg Asn Ile Trp Lys Gly Phe Leu Ile Ser Ile Pro 
            180                 185                 190         


Tyr Ser Ala Ser Ile Gly Gly Thr Ala Thr Leu Thr Gly Thr Ala Pro 
        195                 200                 205             


Asn Leu Ile Leu Leu Gly Gln Leu Lys Ser Phe Phe Pro Gln Cys Asp 
    210                 215                 220                 


Val Val Asn Phe Gly Ser Trp Phe Ile Phe Ala Phe Pro Leu Met Leu 
225                 230                 235                 240 


Leu Phe Leu Leu Ala Gly Trp Leu Trp Ile Ser Phe Leu Tyr Gly Gly 
                245                 250                 255     


Leu Ser Phe Arg Gly Trp Arg Lys Asn Lys Ser Glu Ile Arg Thr Asn 
            260                 265                 270         


Ala Glu Asp Arg Ala Arg Ala Val Ile Arg Glu Glu Tyr Gln Asn Leu 
        275                 280                 285             


Gly Pro Ile Lys Phe Ala Glu Gln Ala Val Phe Ile Leu Phe Cys Met 
    290                 295                 300                 


Phe Ala Ile Leu Leu Phe Thr Arg Asp Pro Lys Phe Ile Pro Gly Trp 
305                 310                 315                 320 


Ala Ser Leu Phe Asn Pro Gly Phe Leu Ser Asp Ala Val Thr Gly Val 
                325                 330                 335     


Ala Ile Val Thr Ile Leu Phe Phe Phe Pro Ser Gln Arg Pro Ser Leu 
            340                 345                 350         


Lys Trp Trp Phe Asp Phe Lys Ala Pro Asn Thr Glu Thr Glu Pro Leu 
        355                 360                 365             


Leu Thr Trp Lys Lys Ala Gln Glu Thr Val Pro Trp Asn Ile Ile Leu 
    370                 375                 380                 


Leu Leu Gly Gly Gly Phe Ala Met Ala Lys Gly Cys Glu Glu Ser Gly 
385                 390                 395                 400 


Leu Ser Val Trp Ile Gly Gly Gln Leu His Pro Leu Glu Asn Val Pro 
                405                 410                 415     


Pro Ala Leu Ala Val Leu Leu Ile Thr Val Val Ile Ala Phe Phe Thr 
            420                 425                 430         


Glu Phe Ala Ser Asn Thr Ala Thr Ile Ile Ile Phe Leu Pro Val Leu 
        435                 440                 445             


Ala Glu Leu Ala Ile Arg Leu Arg Val His Pro Leu Tyr Leu Met Ile 
    450                 455                 460                 


Pro Gly Thr Val Gly Cys Ser Phe Ala Phe Met Leu Pro Val Ser Thr 
465                 470                 475                 480 


Pro Pro Asn Ser Ile Ala Phe Ala Ser Gly His Leu Leu Val Lys Asp 
                485                 490                 495     


Met Val Arg Thr Gly Leu Leu Met Asn Leu Met Gly Val Leu Leu Leu 
            500                 505                 510         


Ser Leu Ala Met Asn Thr Trp Ala Gln Thr Ile Phe Gln Leu Gly Thr 
        515                 520                 525             


Phe Pro Asp Trp Ala Asp Met Tyr Ser Val Asn Val Thr Ala Leu Pro 
    530                 535                 540                 


Pro Thr Leu Ala Asn Asp Thr Phe Arg Thr Leu 
545                 550                 555 


<210>  590
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  590

Met Thr Glu Asn Ser Asp Lys Val Pro Ile Ala Leu Val Gly Pro Asp 
1               5                   10                  15      


Asp Val Glu Phe Cys Ser Pro Pro Ala Tyr Ala Thr Leu Thr Val Lys 
            20                  25                  30          


Pro Ser Ser Pro Ala Arg Leu Leu Lys Val Gly Ala Val Val Leu Ile 
        35                  40                  45              


Ser Gly Ala Val Leu Leu Leu Phe Gly Ala Ile Gly Ala Phe Tyr Phe 
    50                  55                  60                  


Trp Lys Gly Ser Asp Ser His Ile Tyr Asn Val His Tyr Thr Met Ser 
65                  70                  75                  80  


Ile Asn Gly Lys Leu Gln Asp Gly Ser Met Glu Ile Asp Ala Gly Asn 
                85                  90                  95      


Asn Leu Glu Thr Phe Lys Met Gly Ser Gly Ala Glu Glu Ala Ile Ala 
            100                 105                 110         


Val Asn Asp Phe Gln Asn Gly Ile Thr Gly Ile Arg Phe Ala Gly Gly 
        115                 120                 125             


Glu Lys Cys Tyr Ile Lys Ala Gln Val Lys Ala Arg Ile Pro Glu Val 
    130                 135                 140                 


Gly Ala Val Thr Lys Gln Ser Ile Ser Ser Lys Leu Glu Gly Lys Ile 
145                 150                 155                 160 


Met Pro Val Lys Tyr Glu Glu Asn Ser Leu Ile Trp Val Ala Val Asp 
                165                 170                 175     


Gln Pro Val Lys Asp Asn Ser Phe Leu Ser Ser Lys Val Leu Glu Leu 
            180                 185                 190         


Cys Gly Asp Leu Pro Ile Phe Trp Leu Lys Pro Thr Tyr Pro Lys Glu 
        195                 200                 205             


Ile Gln Arg Glu Arg Arg Glu Val Val Arg Lys Ile Val Pro Thr Thr 
    210                 215                 220                 


Thr Lys Arg Pro His Ser Gly Pro Arg Ser Asn Pro Gly Ala Gly Arg 
225                 230                 235                 240 


Leu Asn Asn Glu Thr Arg Pro Ser Val Gln Glu Asp Ser Gln Ala Phe 
                245                 250                 255     


Asn Pro Asp Asn Pro Tyr His Gln Glu Gly Glu Ser Met Thr Phe Asp 
            260                 265                 270         


Pro Arg Leu Asp His Glu Gly Ile Cys Cys Ile Glu Cys Arg Arg Ser 
        275                 280                 285             


Tyr Thr His Cys Gln Lys Ile Cys Glu Pro Leu Gly Gly Tyr Tyr Pro 
    290                 295                 300                 


Trp Pro Tyr Asn Tyr Gln Gly Cys Arg Ser Ala Cys Arg Val Ile Met 
305                 310                 315                 320 


Pro Cys Ser Trp Trp Val Ala Arg Ile Leu Gly Met Val 
                325                 330             


<210>  591
<211>  782
<212>  PRT
<213>  Homo sapiens

<400>  591

Met Gln Gly Glu Glu Ser Leu Arg Ile Leu Val Glu Pro Glu Gly Asp 
1               5                   10                  15      


Ser Phe Pro Leu Met Glu Ile Ser Thr Cys Glu Thr Glu Ala Ser Glu 
            20                  25                  30          


Gln Trp Asp Tyr Val Leu Val Ala Gln Arg His Thr Gln Arg Asp Pro 
        35                  40                  45              


Arg Gln Ala Arg Gln Gln Gln Phe Leu Glu Glu Leu Arg Arg Lys Gly 
    50                  55                  60                  


Phe His Ile Lys Val Ile Arg Asp Gln Lys Gln Val Phe Phe Gly Ile 
65                  70                  75                  80  


Arg Ala Asp Asn Ser Val Phe Gly Leu Tyr Arg Thr Leu Leu Leu Glu 
                85                  90                  95      


Pro Glu Gly Pro Ala Pro His Ala Glu Leu Ala Ala Pro Thr Thr Ile 
            100                 105                 110         


Pro Val Thr Thr Ser Leu Arg Ile Arg Ile Val Asn Phe Val Val Met 
        115                 120                 125             


Asn Asn Lys Thr Ser Ala Gly Glu Thr Phe Glu Asp Leu Met Lys Asp 
    130                 135                 140                 


Gly Val Phe Glu Ala Arg Phe Pro Leu His Lys Gly Glu Gly Arg Leu 
145                 150                 155                 160 


Lys Lys Thr Trp Ala Arg Trp Arg His Met Phe Arg Glu Gln Pro Val 
                165                 170                 175     


Asp Glu Ile Arg Asn Tyr Phe Gly Glu Lys Val Ala Leu Tyr Phe Val 
            180                 185                 190         


Trp Leu Gly Trp Tyr Thr Tyr Met Leu Val Pro Ala Ala Leu Thr Gly 
        195                 200                 205             


Leu Leu Val Phe Leu Ser Gly Phe Ser Leu Phe Glu Ala Ser Gln Ile 
    210                 215                 220                 


Ser Lys Glu Ile Cys Glu Ala His Asp Ile Leu Met Cys Pro Leu Gly 
225                 230                 235                 240 


Asp His Ser Arg Arg Tyr Gln Arg Leu Ser Glu Thr Cys Thr Phe Ala 
                245                 250                 255     


Lys Leu Thr His Leu Phe Asp Asn Asp Gly Thr Val Val Phe Ala Ile 
            260                 265                 270         


Phe Met Ala Leu Trp Ala Thr Val Phe Leu Glu Ile Trp Lys Arg Gln 
        275                 280                 285             


Arg Ala Arg Val Val Leu His Trp Asp Leu Tyr Val Trp Asp Glu Glu 
    290                 295                 300                 


Gln Glu Glu Met Ala Leu Gln Leu Ile Asn Cys Pro Asp Tyr Lys Leu 
305                 310                 315                 320 


Arg Pro Tyr Gln His Ser Tyr Leu Arg Ser Thr Val Ile Leu Val Leu 
                325                 330                 335     


Thr Leu Leu Met Ile Cys Leu Met Ile Gly Met Ala His Val Leu Val 
            340                 345                 350         


Val Tyr Arg Val Leu Ala Ser Ala Leu Phe Ser Ser Ser Ala Val Pro 
        355                 360                 365             


Phe Leu Glu Glu Gln Val Thr Thr Ala Val Val Val Thr Gly Ala Leu 
    370                 375                 380                 


Val His Tyr Val Thr Ile Ile Ile Met Thr Lys Ile Asn Arg Cys Val 
385                 390                 395                 400 


Ala Leu Lys Leu Cys Asp Phe Glu Met Pro Arg Thr Phe Ser Glu Arg 
                405                 410                 415     


Glu Ser Arg Phe Thr Ile Arg Phe Phe Thr Leu Gln Phe Phe Thr His 
            420                 425                 430         


Phe Ser Ser Leu Ile Tyr Ile Ala Phe Ile Leu Gly Arg Ile Asn Gly 
        435                 440                 445             


His Pro Gly Lys Ser Thr Arg Leu Ala Gly Leu Trp Lys Leu Glu Glu 
    450                 455                 460                 


Cys His Ala Ser Gly Cys Met Met Asp Leu Phe Val Gln Met Ala Ile 
465                 470                 475                 480 


Ile Met Gly Leu Lys Gln Thr Leu Ser Asn Cys Val Glu Tyr Leu Val 
                485                 490                 495     


Pro Trp Val Thr His Lys Cys Arg Ser Leu Arg Ala Ser Glu Ser Gly 
            500                 505                 510         


His Leu Pro Arg Asp Pro Glu Leu Arg Asp Trp Arg Arg Asn Tyr Leu 
        515                 520                 525             


Leu Asn Pro Val Asn Thr Phe Ser Leu Phe Asp Glu Phe Met Glu Met 
    530                 535                 540                 


Met Ile Gln Tyr Gly Phe Thr Thr Ile Phe Val Ala Ala Phe Pro Leu 
545                 550                 555                 560 


Ala Pro Leu Leu Ala Leu Phe Ser Asn Leu Val Glu Ile Arg Leu Asp 
                565                 570                 575     


Ala Ile Lys Met Val Trp Leu Gln Arg Arg Leu Val Pro Arg Lys Ala 
            580                 585                 590         


Lys Asp Ile Gly Thr Trp Leu Gln Val Leu Glu Thr Ile Gly Val Leu 
        595                 600                 605             


Ala Val Ile Ala Asn Gly Met Val Ile Ala Phe Thr Ser Glu Phe Ile 
    610                 615                 620                 


Pro Arg Val Val Tyr Lys Tyr Arg Tyr Ser Pro Cys Leu Lys Glu Gly 
625                 630                 635                 640 


Asn Ser Thr Val Asp Cys Leu Lys Gly Tyr Val Asn His Ser Leu Ser 
                645                 650                 655     


Val Phe His Thr Lys Asp Phe Gln Asp Pro Asp Gly Ile Glu Gly Ser 
            660                 665                 670         


Glu Asn Val Thr Leu Cys Arg Tyr Arg Asp Tyr Arg Asn Pro Pro Asp 
        675                 680                 685             


Tyr Asn Phe Ser Glu Gln Phe Trp Phe Leu Leu Ala Ile Arg Leu Ala 
    690                 695                 700                 


Phe Val Ile Leu Phe Glu His Val Ala Leu Cys Ile Lys Leu Ile Ala 
705                 710                 715                 720 


Ala Trp Phe Val Pro Asp Ile Pro Gln Ser Val Lys Asn Lys Val Leu 
                725                 730                 735     


Glu Val Lys Tyr Gln Arg Leu Arg Glu Lys Met Trp His Gly Arg Gln 
            740                 745                 750         


Arg Leu Gly Gly Val Gly Ala Gly Ser Arg Pro Pro Met Pro Ala His 
        755                 760                 765             


Pro Thr Pro Ala Ser Ile Phe Ser Ala Arg Ser Thr Asp Val 
    770                 775                 780         


<210>  592
<211>  790
<212>  PRT
<213>  Homo sapiens

<400>  592

Met Leu Arg Gly Gly Arg Arg Gly Gln Leu Gly Trp His Ser Trp Ala 
1               5                   10                  15      


Ala Gly Pro Gly Ser Leu Leu Ala Trp Leu Ile Leu Ala Ser Ala Gly 
            20                  25                  30          


Ala Ala Pro Cys Pro Asp Ala Cys Cys Pro His Gly Ser Ser Gly Leu 
        35                  40                  45              


Arg Cys Thr Arg Asp Gly Ala Leu Asp Ser Leu His His Leu Pro Gly 
    50                  55                  60                  


Ala Glu Asn Leu Thr Glu Leu Tyr Ile Glu Asn Gln Gln His Leu Gln 
65                  70                  75                  80  


His Leu Glu Leu Arg Asp Leu Arg Gly Leu Gly Glu Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Lys Ser Gly Leu Arg Phe Val Ala Pro Asp Ala Phe His 
            100                 105                 110         


Phe Thr Pro Arg Leu Ser Arg Leu Asn Leu Ser Phe Asn Ala Leu Glu 
        115                 120                 125             


Ser Leu Ser Trp Lys Thr Val Gln Gly Leu Ser Leu Gln Glu Leu Val 
    130                 135                 140                 


Leu Ser Gly Asn Pro Leu His Cys Ser Cys Ala Leu Arg Trp Leu Gln 
145                 150                 155                 160 


Arg Trp Glu Glu Glu Gly Leu Gly Gly Val Pro Glu Gln Lys Leu Gln 
                165                 170                 175     


Cys His Gly Gln Gly Pro Leu Ala His Met Pro Asn Ala Ser Cys Gly 
            180                 185                 190         


Val Pro Thr Leu Lys Val Gln Val Pro Asn Ala Ser Val Asp Val Gly 
        195                 200                 205             


Asp Asp Val Leu Leu Arg Cys Gln Val Glu Gly Arg Gly Leu Glu Gln 
    210                 215                 220                 


Ala Gly Trp Ile Leu Thr Glu Leu Glu Gln Ser Ala Thr Val Met Lys 
225                 230                 235                 240 


Ser Gly Gly Leu Pro Ser Leu Gly Leu Thr Leu Ala Asn Val Thr Ser 
                245                 250                 255     


Asp Leu Asn Arg Lys Asn Val Thr Cys Trp Ala Glu Asn Asp Val Gly 
            260                 265                 270         


Arg Ala Glu Val Ser Val Gln Val Asn Val Ser Phe Pro Ala Ser Val 
        275                 280                 285             


Gln Leu His Thr Ala Val Glu Met His His Trp Cys Ile Pro Phe Ser 
    290                 295                 300                 


Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser 
305                 310                 315                 320 


Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Ala 
                325                 330                 335     


Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr 
            340                 345                 350         


His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Phe Gly 
        355                 360                 365             


Gln Ala Ser Ala Ser Ile Met Ala Ala Phe Met Asp Asn Pro Phe Glu 
    370                 375                 380                 


Phe Asn Pro Glu Asp Pro Ile Pro Asp Thr Asn Ser Thr Ser Gly Asp 
385                 390                 395                 400 


Pro Val Glu Lys Lys Asp Glu Thr Pro Phe Gly Val Ser Val Ala Val 
                405                 410                 415     


Gly Leu Ala Val Phe Ala Cys Leu Phe Leu Ser Thr Leu Leu Leu Val 
            420                 425                 430         


Leu Asn Lys Cys Gly Arg Arg Asn Lys Phe Gly Ile Asn Arg Pro Ala 
        435                 440                 445             


Val Leu Ala Pro Glu Asp Gly Leu Ala Met Ser Leu His Phe Met Thr 
    450                 455                 460                 


Leu Gly Gly Ser Ser Leu Ser Pro Thr Glu Gly Lys Gly Ser Gly Leu 
465                 470                 475                 480 


Gln Gly His Ile Ile Glu Asn Pro Gln Tyr Phe Ser Asp Ala Cys Val 
                485                 490                 495     


His His Ile Lys Arg Arg Asp Ile Val Leu Lys Trp Glu Leu Gly Glu 
            500                 505                 510         


Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys His Asn Leu Leu Pro 
        515                 520                 525             


Glu Gln Asp Lys Met Leu Val Ala Val Lys Ala Leu Lys Glu Ala Ser 
    530                 535                 540                 


Glu Ser Ala Arg Gln Asp Phe Gln Arg Glu Ala Glu Leu Leu Thr Met 
545                 550                 555                 560 


Leu Gln His Gln His Ile Val Arg Phe Phe Gly Val Cys Thr Glu Gly 
                565                 570                 575     


Arg Pro Leu Leu Met Val Phe Glu Tyr Met Arg His Gly Asp Leu Asn 
            580                 585                 590         


Arg Phe Leu Arg Ser His Gly Pro Asp Ala Lys Leu Leu Ala Gly Gly 
        595                 600                 605             


Glu Asp Val Ala Pro Gly Pro Leu Gly Leu Gly Gln Leu Leu Ala Val 
    610                 615                 620                 


Ala Ser Gln Val Ala Ala Gly Met Val Tyr Leu Ala Gly Leu His Phe 
625                 630                 635                 640 


Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Gln Gly Leu 
                645                 650                 655     


Val Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Ile Tyr Ser Thr 
            660                 665                 670         


Asp Tyr Tyr Arg Val Gly Gly Arg Thr Met Leu Pro Ile Arg Trp Met 
        675                 680                 685             


Pro Pro Glu Ser Ile Leu Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val 
    690                 695                 700                 


Trp Ser Phe Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln 
705                 710                 715                 720 


Pro Trp Tyr Gln Leu Ser Asn Thr Glu Ala Ile Asp Cys Ile Thr Gln 
                725                 730                 735     


Gly Arg Glu Leu Glu Arg Pro Arg Ala Cys Pro Pro Glu Val Tyr Ala 
            740                 745                 750         


Ile Met Arg Gly Cys Trp Gln Arg Glu Pro Gln Gln Arg His Ser Ile 
        755                 760                 765             


Lys Asp Val His Ala Arg Leu Gln Ala Leu Ala Gln Ala Pro Pro Val 
    770                 775                 780                 


Tyr Leu Asp Val Leu Gly 
785                 790 


<210>  593
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  593

Met Asp Val Ser Leu Cys Pro Ala Lys Cys Ser Phe Trp Arg Ile Phe 
1               5                   10                  15      


Leu Leu Gly Ser Val Trp Leu Asp Tyr Val Gly Ser Val Leu Ala Cys 
            20                  25                  30          


Pro Ala Asn Cys Val Cys Ser Lys Thr Glu Ile Asn Cys Arg Arg Pro 
        35                  40                  45              


Asp Asp Gly Asn Leu Phe Pro Leu Leu Glu Gly Gln Asp Ser Gly Asn 
    50                  55                  60                  


Ser Asn Gly Asn Ala Ser Ile Asn Ile Thr Asp Ile Ser Arg Asn Ile 
65                  70                  75                  80  


Thr Ser Ile His Ile Glu Asn Trp Arg Ser Leu His Thr Leu Asn Ala 
                85                  90                  95      


Val Asp Met Glu Leu Tyr Thr Gly Leu Gln Lys Leu Thr Ile Lys Asn 
            100                 105                 110         


Ser Gly Leu Arg Ser Ile Gln Pro Arg Ala Phe Ala Lys Asn Pro His 
        115                 120                 125             


Leu Arg Tyr Ile Asn Leu Ser Ser Asn Arg Leu Thr Thr Leu Ser Trp 
    130                 135                 140                 


Gln Leu Phe Gln Thr Leu Ser Leu Arg Glu Leu Gln Leu Glu Gln Asn 
145                 150                 155                 160 


Phe Phe Asn Cys Ser Cys Asp Ile Arg Trp Met Gln Leu Trp Gln Glu 
                165                 170                 175     


Gln Gly Glu Ala Lys Leu Asn Ser Gln Asn Leu Tyr Cys Ile Asn Ala 
            180                 185                 190         


Asp Gly Ser Gln Leu Pro Leu Phe Arg Met Asn Ile Ser Gln Cys Asp 
        195                 200                 205             


Leu Pro Glu Ile Ser Val Ser His Val Asn Leu Thr Val Arg Glu Gly 
    210                 215                 220                 


Asp Asn Ala Val Ile Thr Cys Asn Gly Ser Gly Ser Pro Leu Pro Asp 
225                 230                 235                 240 


Val Asp Trp Ile Val Thr Gly Leu Gln Ser Ile Asn Thr His Gln Thr 
                245                 250                 255     


Asn Leu Asn Trp Thr Asn Val His Ala Ile Asn Leu Thr Leu Val Asn 
            260                 265                 270         


Val Thr Ser Glu Asp Asn Gly Phe Thr Leu Thr Cys Ile Ala Glu Asn 
        275                 280                 285             


Val Val Gly Met Ser Asn Ala Ser Val Ala Leu Thr Val Tyr Tyr Pro 
    290                 295                 300                 


Pro Arg Val Val Ser Leu Glu Glu Pro Glu Leu Arg Leu Glu His Cys 
305                 310                 315                 320 


Ile Glu Phe Val Val Arg Gly Asn Pro Pro Pro Thr Leu His Trp Leu 
                325                 330                 335     


His Asn Gly Gln Pro Leu Arg Glu Ser Lys Ile Ile His Val Glu Tyr 
            340                 345                 350         


Tyr Gln Glu Gly Glu Ile Ser Glu Gly Cys Leu Leu Phe Asn Lys Pro 
        355                 360                 365             


Thr His Tyr Asn Asn Gly Asn Tyr Thr Leu Ile Ala Lys Asn Pro Leu 
    370                 375                 380                 


Gly Thr Ala Asn Gln Thr Ile Asn Gly His Phe Leu Lys Glu Pro Phe 
385                 390                 395                 400 


Pro Glu Ser Thr Asp Asn Phe Ile Leu Phe Asp Glu Val Ser Pro Thr 
                405                 410                 415     


Pro Pro Ile Thr Val Thr His Lys Pro Glu Glu Asp Thr Phe Gly Val 
            420                 425                 430         


Ser Ile Ala Val Gly Leu Ala Ala Phe Ala Cys Val Leu Leu Val Val 
        435                 440                 445             


Leu Phe Val Met Ile Asn Lys Tyr Gly Arg Arg Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Gly Pro Val Ala Val Ile Ser Gly Glu Glu Asp Ser Ala Ser Pro 
465                 470                 475                 480 


Leu His His Ile Asn His Gly Ile Thr Thr Pro Ser Ser Leu Asp Ala 
                485                 490                 495     


Gly Pro Asp Thr Val Val Ile Gly Met Thr Arg Ile Pro Val Ile Glu 
            500                 505                 510         


Asn Pro Gln Tyr Phe Arg Gln Gly His Asn Cys His Lys Pro Asp Thr 
        515                 520                 525             


Tyr Val Gln His Ile Lys Arg Arg Asp Ile Val Leu Lys Arg Glu Leu 
    530                 535                 540                 


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu 
545                 550                 555                 560 


Ser Pro Thr Lys Asp Lys Met Leu Val Ala Val Lys Ala Leu Lys Asp 
                565                 570                 575     


Pro Thr Leu Ala Ala Arg Lys Asp Phe Gln Arg Glu Ala Glu Leu Leu 
            580                 585                 590         


Thr Asn Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Gly 
        595                 600                 605             


Asp Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp 
    610                 615                 620                 


Leu Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala Met Ile Leu Val 
625                 630                 635                 640 


Asp Gly Gln Pro Arg Gln Ala Lys Gly Glu Leu Gly Leu Ser Gln Met 
                645                 650                 655     


Leu His Ile Ala Ser Gln Ile Ala Ser Gly Met Val Tyr Leu Ala Ser 
            660                 665                 670         


Gln His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly 
        675                 680                 685             


Ala Asn Leu Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val 
    690                 695                 700                 


Tyr Ser Thr Asp Tyr Tyr Arg Leu Phe Asn Pro Ser Gly Asn Asp Phe 
705                 710                 715                 720 


Cys Ile Trp Cys Glu Val Gly Gly His Thr Met Leu Pro Ile Arg Trp 
                725                 730                 735     


Met Pro Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu Ser Asp 
            740                 745                 750         


Val Trp Ser Phe Gly Val Ile Leu Trp Glu Ile Phe Thr Tyr Gly Lys 
        755                 760                 765             


Gln Pro Trp Phe Gln Leu Ser Asn Thr Glu Val Ile Glu Cys Ile Thr 
    770                 775                 780                 


Gln Gly Arg Val Leu Glu Arg Pro Arg Val Cys Pro Lys Glu Val Tyr 
785                 790                 795                 800 


Asp Val Met Leu Gly Cys Trp Gln Arg Glu Pro Gln Gln Arg Leu Asn 
                805                 810                 815     


Ile Lys Glu Ile Tyr Lys Ile Leu His Ala Leu Gly Lys Ala Thr Pro 
            820                 825                 830         


Ile Tyr Leu Asp Ile Leu Gly 
        835                 


<210>  594
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  594

Met Tyr His Pro Ala Tyr Trp Val Val Phe Ser Ala Thr Thr Ala Leu 
1               5                   10                  15      


Leu Phe Ile Pro Gly Val Pro Val Arg Ser Gly Asp Ala Thr Phe Pro 
            20                  25                  30          


Lys Ala Met Asp Asn Val Thr Val Arg Gln Gly Glu Ser Ala Thr Leu 
        35                  40                  45              


Arg Cys Thr Ile Asp Asp Arg Val Thr Arg Val Ala Trp Leu Asn Arg 
    50                  55                  60                  


Ser Thr Ile Leu Tyr Ala Gly Asn Asp Lys Trp Ser Ile Asp Pro Arg 
65                  70                  75                  80  


Val Ile Ile Leu Val Asn Thr Pro Thr Gln Tyr Ser Ile Met Ile Gln 
                85                  90                  95      


Asn Val Asp Val Tyr Asp Glu Gly Pro Tyr Thr Cys Ser Val Gln Thr 
            100                 105                 110         


Asp Asn His Pro Lys Thr Ser Arg Val His Leu Ile Val Gln Val Pro 
        115                 120                 125             


Pro Gln Ile Met Asn Ile Ser Ser Asp Ile Thr Val Asn Glu Gly Ser 
    130                 135                 140                 


Ser Val Thr Leu Leu Cys Leu Ala Ile Gly Arg Pro Glu Pro Thr Val 
145                 150                 155                 160 


Thr Trp Arg His Leu Ser Val Lys Glu Gly Gln Gly Phe Val Ser Glu 
                165                 170                 175     


Asp Glu Tyr Leu Glu Ile Ser Asp Ile Lys Arg Asp Gln Ser Gly Glu 
            180                 185                 190         


Tyr Glu Cys Ser Ala Leu Asn Asp Val Ala Ala Pro Asp Val Arg Lys 
        195                 200                 205             


Val Lys Ile Thr Val Asn Tyr Pro Pro Tyr Ile Ser Lys Ala Lys Asn 
    210                 215                 220                 


Thr Gly Val Ser Val Gly Gln Lys Gly Ile Leu Ser Cys Glu Ala Ser 
225                 230                 235                 240 


Ala Val Pro Met Ala Glu Phe Gln Trp Phe Lys Glu Glu Thr Arg Leu 
                245                 250                 255     


Ala Thr Gly Leu Asp Gly Met Arg Ile Glu Asn Lys Gly Arg Met Ser 
            260                 265                 270         


Thr Leu Thr Phe Phe Asn Val Ser Glu Lys Asp Tyr Gly Asn Tyr Thr 
        275                 280                 285             


Cys Val Ala Thr Asn Lys Leu Gly Asn Thr Asn Ala Ser Ile Thr Leu 
    290                 295                 300                 


Tyr Gly Pro Gly Ala Val Ile Asp Gly Val Asn Ser Ala Ser Arg Ala 
305                 310                 315                 320 


Leu Ala Cys Leu Trp Leu Ser Gly Thr Leu Leu Ala His Phe Phe Ile 
                325                 330                 335     


Lys Phe 
        


<210>  595
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  595

Met Leu Gln Leu Thr Gly Glu Asn Glu Lys Asn Cys Glu Val Ser Glu 
1               5                   10                  15      


Arg Ile Arg Arg Ser Gly Pro Trp Lys Glu Ile Ser Phe Gly Asp Tyr 
            20                  25                  30          


Ile Cys His Thr Phe Gln Gly Asp Cys Trp Ala Asp Arg Ser Pro Leu 
        35                  40                  45              


His Glu Ala Ala Ala Gln Gly Arg Leu Leu Ala Leu Lys Thr Leu Ile 
    50                  55                  60                  


Ala Gln Gly Val Asn Val Asn Leu Val Thr Ile Asn Arg Val Ser Ser 
65                  70                  75                  80  


Leu His Glu Ala Cys Leu Gly Gly His Val Ala Cys Ala Lys Ala Leu 
                85                  90                  95      


Leu Glu Asn Gly Ala His Val Asn Gly Val Thr Val His Gly Ala Thr 
            100                 105                 110         


Pro Leu Phe Asn Ala Cys Cys Ser Gly Ser Ala Ala Cys Val Asn Val 
        115                 120                 125             


Leu Leu Glu Phe Gly Ala Lys Ala Gln Leu Glu Val His Leu Ala Ser 
    130                 135                 140                 


Pro Ile His Glu Ala Val Lys Arg Gly His Arg Glu Cys Met Glu Ile 
145                 150                 155                 160 


Leu Leu Ala Asn Asn Val Asn Ile Asp His Glu Val Pro Gln Leu Gly 
                165                 170                 175     


Thr Pro Leu Tyr Val Ala Cys Thr Tyr Gln Arg Val Asp Cys Val Lys 
            180                 185                 190         


Lys Leu Leu Glu Leu Gly Ala Ser Val Asp His Gly Gln Trp Leu Asp 
        195                 200                 205             


Thr Pro Leu His Ala Ala Ala Arg Gln Ser Asn Val Glu Val Ile His 
    210                 215                 220                 


Leu Leu Thr Asp Tyr Gly Ala Asn Leu Lys Arg Arg Asn Ala Gln Gly 
225                 230                 235                 240 


Lys Ser Ala Leu Asp Leu Ala Ala Pro Lys Ser Ser Val Glu Gln Ala 
                245                 250                 255     


Leu Leu Leu Arg Glu Gly Pro Pro Ala Leu Ser Gln Leu Cys Arg Leu 
            260                 265                 270         


Cys Val Arg Lys Cys Leu Gly Arg Ala Cys His Gln Ala Ile His Lys 
        275                 280                 285             


Leu His Leu Pro Glu Pro Leu Glu Arg Phe Leu Leu Tyr Gln 
    290                 295                 300         


<210>  596
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  596

Met Asp Gln Val Met Gln Phe Val Glu Pro Ser Arg Gln Phe Val Lys 
1               5                   10                  15      


Asp Ser Ile Arg Leu Val Lys Arg Cys Thr Lys Pro Asp Arg Lys Glu 
            20                  25                  30          


Phe Gln Lys Ile Ala Met Ala Thr Ala Ile Gly Phe Ala Ile Met Gly 
        35                  40                  45              


Phe Ile Gly Phe Phe Val Lys Leu Ile His Ile Pro Ile Asn Asn Ile 
    50                  55                  60                  


Ile Val Gly Gly 
65              


<210>  597
<211>  460
<212>  PRT
<213>  Homo sapiens

<400>  597

Met Gly Ser Asn Ser Gly Gln Ala Gly Arg His Ile Tyr Lys Ser Leu 
1               5                   10                  15      


Ala Asp Asp Gly Pro Phe Asp Ser Val Glu Pro Pro Lys Arg Pro Thr 
            20                  25                  30          


Ser Arg Leu Ile Met His Ser Met Ala Met Phe Gly Arg Glu Phe Cys 
        35                  40                  45              


Tyr Ala Val Glu Ala Ala Tyr Val Thr Pro Val Leu Leu Ser Val Gly 
    50                  55                  60                  


Leu Pro Ser Ser Leu Tyr Ser Ile Val Trp Phe Leu Ser Pro Ile Leu 
65                  70                  75                  80  


Gly Phe Leu Leu Gln Pro Val Val Gly Ser Ala Ser Asp His Cys Arg 
                85                  90                  95      


Ser Arg Trp Gly Arg Arg Arg Pro Tyr Ile Leu Thr Leu Gly Val Met 
            100                 105                 110         


Met Leu Val Gly Met Ala Leu Tyr Leu Asn Gly Ala Thr Val Val Ala 
        115                 120                 125             


Ala Leu Ile Ala Asn Pro Arg Arg Lys Leu Val Trp Ala Ile Ser Val 
    130                 135                 140                 


Thr Met Ile Gly Val Val Leu Phe Asp Phe Ala Ala Asp Phe Ile Asp 
145                 150                 155                 160 


Gly Pro Ile Lys Ala Tyr Leu Phe Asp Val Cys Ser His Gln Asp Lys 
                165                 170                 175     


Glu Lys Gly Leu His Tyr His Ala Leu Phe Thr Gly Phe Gly Gly Ala 
            180                 185                 190         


Leu Gly Tyr Leu Leu Gly Ala Ile Asp Trp Ala His Leu Glu Leu Gly 
        195                 200                 205             


Arg Leu Leu Gly Thr Glu Phe Gln Val Met Phe Phe Phe Ser Ala Leu 
    210                 215                 220                 


Val Leu Thr Leu Cys Phe Thr Val His Leu Cys Ser Ile Ser Glu Ala 
225                 230                 235                 240 


Pro Leu Thr Glu Val Ala Lys Gly Ile Pro Pro Gln Gln Thr Pro Gln 
                245                 250                 255     


Asp Pro Pro Leu Ser Ser Asp Gly Met Tyr Glu Tyr Gly Ser Ile Glu 
            260                 265                 270         


Lys Val Lys Asn Gly Tyr Val Asn Pro Glu Leu Ala Met Gln Gly Ala 
        275                 280                 285             


Lys Asn Lys Asn His Ala Glu Gln Thr Arg Arg Ala Met Thr Leu Lys 
    290                 295                 300                 


Ser Leu Leu Arg Ala Leu Val Asn Met Pro Pro His Tyr Arg Tyr Leu 
305                 310                 315                 320 


Cys Ile Ser His Leu Ile Gly Trp Thr Ala Phe Leu Ser Asn Met Leu 
                325                 330                 335     


Phe Phe Thr Asp Phe Met Gly Gln Ile Val Tyr Arg Gly Asp Pro Tyr 
            340                 345                 350         


Ser Ala His Asn Ser Thr Glu Phe Leu Ile Tyr Glu Arg Gly Val Glu 
        355                 360                 365             


Val Gly Cys Trp Gly Phe Cys Ile Asn Ser Val Phe Ser Ser Leu Tyr 
    370                 375                 380                 


Ser Tyr Phe Gln Lys Val Leu Val Ser Tyr Ile Gly Leu Lys Gly Leu 
385                 390                 395                 400 


Tyr Phe Thr Gly Tyr Leu Leu Phe Gly Leu Gly Thr Gly Phe Ile Gly 
                405                 410                 415     


Leu Phe Pro Asn Val Tyr Ser Thr Leu Val Leu Cys Ser Leu Phe Gly 
            420                 425                 430         


Val Met Ser Ser Thr Leu Tyr Thr Val Pro Phe Asn Leu Ile Thr Glu 
        435                 440                 445             


Tyr His Arg Glu Glu Glu Lys Glu Val Cys Cys His 
    450                 455                 460 


<210>  598
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  598

Met Asp Pro Leu Phe Gln Gln Thr His Lys Gln Val His Glu Ile Gln 
1               5                   10                  15      


Ser Cys Met Gly Arg Leu Glu Thr Ala Asp Lys Gln Ser Val His Ile 
            20                  25                  30          


Val Glu Asn Glu Ile Gln Ala Ser Ile Asp Gln Ile Phe Ser Arg Leu 
        35                  40                  45              


Glu Arg Leu Glu Ile Leu Ser Ser Lys Glu Pro Pro Asn Lys Arg Gln 
    50                  55                  60                  


Asn Ala Arg Leu Arg Val Asp Gln Leu Lys Tyr Asp Val Gln His Leu 
65                  70                  75                  80  


Gln Thr Ala Leu Arg Asn Phe Gln His Arg Arg His Ala Arg Glu Gln 
                85                  90                  95      


Gln Glu Arg Gln Arg Glu Glu Leu Leu Ser Arg Thr Phe Thr Thr Asn 
            100                 105                 110         


Asp Ser Asp Thr Thr Ile Pro Met Asp Glu Ser Leu Gln Phe Asn Ser 
        115                 120                 125             


Ser Leu Gln Lys Val His Asn Gly Met Asp Asp Leu Ile Leu Asp Gly 
    130                 135                 140                 


His Asn Ile Leu Asp Gly Leu Arg Thr Gln Arg Leu Thr Leu Lys Val 
145                 150                 155                 160 


Gly Ser Leu Leu Gly Asp Arg Glu Lys Ala Ser Cys Phe Ser Leu Ile 
                165                 170                 175     


Gln Gln Phe Ser Asn Cys Val Tyr Ile Leu Ile Thr Cys Pro Gln Ile 
            180                 185                 190         


Val Ile Phe 
        195 


<210>  599
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  599

Met Thr Ala Leu Ser Arg Ser Glu Ala Thr Glu Glu Gly Gly Asn Gln 
1               5                   10                  15      


Gln Met His Arg Lys Thr Ala Ser Leu Asn Ser Pro Val Ser Cys Lys 
            20                  25                  30          


Glu Lys Pro Asp Arg Val Glu Glu Pro Pro Asp Tyr Ser Leu His Trp 
        35                  40                  45              


Pro Glu Gly Leu Lys Gly Glu Glu Ile Lys Lys Cys Gly Arg Glu Gly 
    50                  55                  60                  


Ile Thr Leu Asn Lys Tyr Asn Gln Gln Tyr His Lys Leu Phe Lys Asp 
65                  70                  75                  80  


Val Pro Leu Glu Glu Val Val Leu Lys Val Cys Ser Cys Ala Leu Gln 
                85                  90                  95      


Arg Asp Phe Leu Leu Gln Gly Arg Leu Tyr Ile Ser Pro Asn Trp Leu 
            100                 105                 110         


Cys Phe His Ala Ser Leu Phe Gly Lys Asp Ile Lys Val Val Ile Pro 
        115                 120                 125             


Val Val Ser Val Gln Met Ile Lys Lys His Lys Met Ala Arg Leu Leu 
    130                 135                 140                 


Pro Asn Gly Leu Ala Ile Thr Thr Asn Thr Ser Gln Lys Tyr Ile Phe 
145                 150                 155                 160 


Val Ser Leu Leu Ser Arg Asp Ser Val Tyr Asp Leu Leu Arg Arg Val 
                165                 170                 175     


Cys Thr His Leu Gln Pro Ser Ser Lys Lys Ser Leu Ser Val Arg Glu 
            180                 185                 190         


Phe Ser Gly Glu Pro Glu Ser Leu Glu Val Leu Ile Pro Glu Met Lys 
        195                 200                 205             


Trp Arg Lys Val Cys Pro Ser Ser Arg Ser Leu Ser Leu Pro Asp Asn 
    210                 215                 220                 


Ile Pro Cys Ile Pro Pro Ser Ser Val Asp Ser Thr Asp Ser Phe Phe 
225                 230                 235                 240 


Pro Ser Arg Lys Pro Pro Met Ser Glu Lys Ser Arg Ala Gln Val Ala 
                245                 250                 255     


Ser Glu Asn Gly Gly Arg Trp Ala Trp Pro Met Pro Gly Trp Gly Pro 
            260                 265                 270         


Ala Cys Pro Lys Lys Met Pro Asn Cys Ser Pro Thr Ala Lys Asn Ala 
        275                 280                 285             


Val Tyr Glu Glu Asp Glu Leu Glu Glu Glu Pro Arg Ser Thr Gly Glu 
    290                 295                 300                 


Leu Arg Leu Trp Asp Tyr Arg Leu Leu Lys Val Phe Phe Val Leu Ile 
305                 310                 315                 320 


Cys Phe Leu Val Met Ser Ser Ser Tyr Leu Ala Phe Arg Ile Ser Arg 
                325                 330                 335     


Leu Glu Gln Gln Leu Cys Ser Leu Ser Trp Asp Asp Pro Val Pro Gly 
            340                 345                 350         


His Arg 
        


<210>  600
<211>  631
<212>  PRT
<213>  Homo sapiens

<400>  600

Met Glu Leu Gln Pro Pro Glu Ala Ser Ile Ala Val Val Ser Ile Pro 
1               5                   10                  15      


Arg Gln Leu Pro Gly Ser His Ser Glu Ala Gly Val Gln Gly Leu Ser 
            20                  25                  30          


Ala Gly Asp Asp Ser Glu Thr Gly Ser Asp Cys Val Thr Gln Ala Gly 
        35                  40                  45              


Leu Gln Leu Leu Ala Ser Ser Asp Pro Pro Ala Leu Ala Ser Lys Asn 
    50                  55                  60                  


Ala Glu Val Thr Val Glu Thr Gly Phe His His Val Ser Gln Ala Asp 
65                  70                  75                  80  


Ile Glu Phe Leu Thr Ser Ile Asp Pro Thr Ala Ser Ala Ser Gly Ser 
                85                  90                  95      


Ala Gly Ile Thr Gly Thr Met Ser Gln Asp Thr Glu Val Asp Met Lys 
            100                 105                 110         


Glu Val Glu Leu Asn Glu Leu Glu Pro Glu Lys Gln Pro Met Asn Ala 
        115                 120                 125             


Ala Ser Gly Ala Ala Met Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu 
    130                 135                 140                 


Val Lys Ile Lys Val Ala Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala 
145                 150                 155                 160 


Lys Phe Thr Gly Leu Ser Lys Glu Glu Leu Leu Lys Val Ala Gly Ser 
                165                 170                 175     


Pro Gly Trp Val Arg Thr Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu 
            180                 185                 190         


Gly Trp Leu Gly Met Leu Ala Gly Ala Val Val Ile Ile Val Arg Ala 
        195                 200                 205             


Pro Arg Cys Arg Glu Leu Pro Ala Gln Lys Trp Trp His Thr Gly Ala 
    210                 215                 220                 


Leu Tyr Arg Ile Gly Asp Leu Gln Ala Phe Gln Gly His Gly Ala Gly 
225                 230                 235                 240 


Asn Leu Ala Gly Leu Lys Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys 
                245                 250                 255     


Val Lys Gly Leu Val Leu Gly Pro Ile His Lys Asn Gln Lys Asp Asp 
            260                 265                 270         


Val Ala Gln Thr Asp Leu Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys 
        275                 280                 285             


Glu Asp Phe Asp Ser Leu Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg 
    290                 295                 300                 


Val Ile Leu Asp Leu Thr Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe 
305                 310                 315                 320 


Ser Thr Gln Val Asp Thr Val Ala Thr Lys Val Lys Asp Ala Leu Glu 
                325                 330                 335     


Phe Trp Leu Gln Ala Gly Val Asp Gly Phe Gln Val Arg Asp Ile Glu 
            340                 345                 350         


Asn Leu Lys Asp Ala Ser Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr 
        355                 360                 365             


Lys Gly Phe Ser Glu Asp Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser 
    370                 375                 380                 


Asp Leu Gln Gln Ile Leu Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu 
385                 390                 395                 400 


Leu Thr Ser Ser Tyr Leu Ser Asp Ser Gly Ser Thr Gly Glu His Thr 
                405                 410                 415     


Lys Ser Leu Val Thr Gln Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys 
            420                 425                 430         


Ser Trp Ser Leu Ser Gln Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala 
        435                 440                 445             


Gln Leu Leu Arg Leu Tyr Gln Leu Met Leu Phe Thr Leu Pro Gly Thr 
    450                 455                 460                 


Pro Val Phe Ser Tyr Gly Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu 
465                 470                 475                 480 


Pro Gly Gln Pro Met Glu Ala Pro Val Met Leu Trp Asp Glu Ser Ser 
                485                 490                 495     


Phe Pro Asp Ile Pro Gly Ala Val Ser Ala Asn Met Thr Val Lys Gly 
            500                 505                 510         


Gln Ser Glu Asp Pro Gly Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser 
        515                 520                 525             


Asp Gln Arg Ser Lys Glu Arg Ser Leu Leu His Gly Asp Phe His Ala 
    530                 535                 540                 


Phe Ser Ala Gly Pro Gly Leu Phe Ser Tyr Ile Arg His Trp Asp Gln 
545                 550                 555                 560 


Asn Glu Arg Phe Leu Val Val Leu Asn Phe Gly Asp Val Gly Leu Ser 
                565                 570                 575     


Ala Gly Leu Gln Ala Ser Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala 
            580                 585                 590         


Lys Ala Asp Leu Leu Leu Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser 
        595                 600                 605             


Pro Leu Glu Leu Glu Arg Leu Lys Leu Glu Pro His Glu Gly Leu Leu 
    610                 615                 620                 


Leu Arg Phe Pro Tyr Ala Ala 
625                 630     


<210>  601
<211>  631
<212>  PRT
<213>  Homo sapiens

<400>  601

Met Glu Leu Gln Pro Pro Glu Ala Ser Ile Ala Val Val Ser Ile Pro 
1               5                   10                  15      


Arg Gln Leu Pro Gly Ser His Ser Glu Ala Gly Val Gln Gly Leu Ser 
            20                  25                  30          


Ala Gly Asp Asp Ser Glu Thr Gly Ser Asp Cys Val Thr Gln Ala Gly 
        35                  40                  45              


Leu Gln Leu Leu Ala Ser Ser Asp Pro Pro Ala Leu Ala Ser Lys Asn 
    50                  55                  60                  


Ala Glu Val Thr Val Glu Thr Gly Phe His His Val Ser Gln Ala Asp 
65                  70                  75                  80  


Ile Glu Phe Leu Thr Ser Ile Asp Pro Thr Ala Ser Ala Ser Gly Ser 
                85                  90                  95      


Ala Gly Ile Thr Gly Thr Met Ser Gln Asp Thr Glu Val Asp Met Lys 
            100                 105                 110         


Glu Val Glu Leu Asn Glu Leu Glu Pro Glu Lys Gln Pro Met Asn Ala 
        115                 120                 125             


Ala Ser Gly Ala Ala Met Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu 
    130                 135                 140                 


Val Lys Ile Lys Val Ala Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala 
145                 150                 155                 160 


Lys Phe Thr Gly Leu Ser Lys Glu Glu Leu Leu Lys Val Ala Gly Ser 
                165                 170                 175     


Pro Gly Trp Val Arg Thr Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu 
            180                 185                 190         


Gly Trp Leu Gly Met Leu Ala Gly Ala Val Val Ile Ile Val Arg Ala 
        195                 200                 205             


Pro Arg Cys Arg Glu Leu Pro Ala Gln Lys Trp Trp His Thr Gly Ala 
    210                 215                 220                 


Leu Tyr Arg Ile Gly Asp Leu Gln Ala Phe Gln Gly His Gly Ala Gly 
225                 230                 235                 240 


Asn Leu Ala Gly Leu Lys Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys 
                245                 250                 255     


Val Lys Gly Leu Val Leu Gly Pro Ile His Lys Asn Gln Lys Asp Asp 
            260                 265                 270         


Val Ala Gln Thr Asp Leu Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys 
        275                 280                 285             


Glu Asp Phe Asp Ser Leu Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg 
    290                 295                 300                 


Val Ile Leu Asp Leu Thr Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe 
305                 310                 315                 320 


Ser Thr Gln Val Asp Thr Val Ala Thr Lys Val Lys Asp Ala Leu Glu 
                325                 330                 335     


Phe Trp Leu Gln Ala Gly Val Asp Gly Phe Gln Val Arg Asp Ile Glu 
            340                 345                 350         


Asn Leu Lys Asp Ala Ser Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr 
        355                 360                 365             


Lys Gly Phe Ser Glu Asp Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser 
    370                 375                 380                 


Asp Leu Gln Gln Ile Leu Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu 
385                 390                 395                 400 


Leu Thr Ser Ser Tyr Leu Ser Asp Ser Gly Ser Thr Gly Glu His Thr 
                405                 410                 415     


Lys Ser Leu Val Thr Gln Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys 
            420                 425                 430         


Ser Trp Ser Leu Ser Gln Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala 
        435                 440                 445             


Gln Leu Leu Arg Leu Tyr Gln Leu Met Leu Phe Thr Leu Pro Gly Thr 
    450                 455                 460                 


Pro Val Phe Ser Tyr Gly Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu 
465                 470                 475                 480 


Pro Gly Gln Pro Met Glu Ala Pro Val Met Leu Trp Asp Glu Ser Ser 
                485                 490                 495     


Phe Pro Asp Ile Pro Gly Ala Val Ser Ala Asn Met Thr Val Lys Gly 
            500                 505                 510         


Gln Ser Glu Asp Pro Gly Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser 
        515                 520                 525             


Asp Gln Arg Ser Lys Glu Arg Ser Leu Leu His Gly Asp Phe His Ala 
    530                 535                 540                 


Phe Ser Ala Gly Pro Gly Leu Phe Ser Tyr Ile Arg His Trp Asp Gln 
545                 550                 555                 560 


Asn Glu Arg Phe Leu Val Val Leu Asn Phe Gly Asp Val Gly Leu Ser 
                565                 570                 575     


Ala Gly Leu Gln Ala Ser Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala 
            580                 585                 590         


Lys Ala Asp Leu Leu Leu Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser 
        595                 600                 605             


Pro Leu Glu Leu Glu Arg Leu Lys Leu Glu Pro His Glu Gly Leu Leu 
    610                 615                 620                 


Leu Arg Phe Pro Tyr Ala Ala 
625                 630     


<210>  602
<211>  631
<212>  PRT
<213>  Homo sapiens

<400>  602

Met Glu Leu Gln Pro Pro Glu Ala Ser Ile Ala Val Val Ser Ile Pro 
1               5                   10                  15      


Arg Gln Leu Pro Gly Ser His Ser Glu Ala Gly Val Gln Gly Leu Ser 
            20                  25                  30          


Ala Gly Asp Asp Ser Glu Thr Gly Ser Asp Cys Val Thr Gln Ala Gly 
        35                  40                  45              


Leu Gln Leu Leu Ala Ser Ser Asp Pro Pro Ala Leu Ala Ser Lys Asn 
    50                  55                  60                  


Ala Glu Val Thr Val Glu Thr Gly Phe His His Val Ser Gln Ala Asp 
65                  70                  75                  80  


Ile Glu Phe Leu Thr Ser Ile Asp Pro Thr Ala Ser Ala Ser Gly Ser 
                85                  90                  95      


Ala Gly Ile Thr Gly Thr Met Ser Gln Asp Thr Glu Val Asp Met Lys 
            100                 105                 110         


Glu Val Glu Leu Asn Glu Leu Glu Pro Glu Lys Gln Pro Met Asn Ala 
        115                 120                 125             


Ala Ser Gly Ala Ala Met Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu 
    130                 135                 140                 


Val Lys Ile Lys Val Ala Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala 
145                 150                 155                 160 


Lys Phe Thr Gly Leu Ser Lys Glu Glu Leu Leu Lys Val Ala Gly Ser 
                165                 170                 175     


Pro Gly Trp Val Arg Thr Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu 
            180                 185                 190         


Gly Trp Leu Gly Met Leu Ala Gly Ala Val Val Ile Ile Val Arg Ala 
        195                 200                 205             


Pro Arg Cys Arg Glu Leu Pro Ala Gln Lys Trp Trp His Thr Gly Ala 
    210                 215                 220                 


Leu Tyr Arg Ile Gly Asp Leu Gln Ala Phe Gln Gly His Gly Ala Gly 
225                 230                 235                 240 


Asn Leu Ala Gly Leu Lys Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys 
                245                 250                 255     


Val Lys Gly Leu Val Leu Gly Pro Ile His Lys Asn Gln Lys Asp Asp 
            260                 265                 270         


Val Ala Gln Thr Asp Leu Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys 
        275                 280                 285             


Glu Asp Phe Asp Ser Leu Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg 
    290                 295                 300                 


Val Ile Leu Asp Leu Thr Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe 
305                 310                 315                 320 


Ser Thr Gln Val Asp Thr Val Ala Thr Lys Val Lys Asp Ala Leu Glu 
                325                 330                 335     


Phe Trp Leu Gln Ala Gly Val Asp Gly Phe Gln Val Arg Asp Ile Glu 
            340                 345                 350         


Asn Leu Lys Asp Ala Ser Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr 
        355                 360                 365             


Lys Gly Phe Ser Glu Asp Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser 
    370                 375                 380                 


Asp Leu Gln Gln Ile Leu Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu 
385                 390                 395                 400 


Leu Thr Ser Ser Tyr Leu Ser Asp Ser Gly Ser Thr Gly Glu His Thr 
                405                 410                 415     


Lys Ser Leu Val Thr Gln Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys 
            420                 425                 430         


Ser Trp Ser Leu Ser Gln Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala 
        435                 440                 445             


Gln Leu Leu Arg Leu Tyr Gln Leu Met Leu Phe Thr Leu Pro Gly Thr 
    450                 455                 460                 


Pro Val Phe Ser Tyr Gly Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu 
465                 470                 475                 480 


Pro Gly Gln Pro Met Glu Ala Pro Val Met Leu Trp Asp Glu Ser Ser 
                485                 490                 495     


Phe Pro Asp Ile Pro Gly Ala Val Ser Ala Asn Met Thr Val Lys Gly 
            500                 505                 510         


Gln Ser Glu Asp Pro Gly Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser 
        515                 520                 525             


Asp Gln Arg Ser Lys Glu Arg Ser Leu Leu His Gly Asp Phe His Ala 
    530                 535                 540                 


Phe Ser Ala Gly Pro Gly Leu Phe Ser Tyr Ile Arg His Trp Asp Gln 
545                 550                 555                 560 


Asn Glu Arg Phe Leu Val Val Leu Asn Phe Gly Asp Val Gly Leu Ser 
                565                 570                 575     


Ala Gly Leu Gln Ala Ser Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala 
            580                 585                 590         


Lys Ala Asp Leu Leu Leu Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser 
        595                 600                 605             


Pro Leu Glu Leu Glu Arg Leu Lys Leu Glu Pro His Glu Gly Leu Leu 
    610                 615                 620                 


Leu Arg Phe Pro Tyr Ala Ala 
625                 630     


<210>  603
<211>  568
<212>  PRT
<213>  Homo sapiens

<400>  603

Met Glu Leu Gln Pro Pro Glu Ala Ser Ile Ala Val Val Ser Ile Pro 
1               5                   10                  15      


Arg Gln Leu Pro Gly Ser His Ser Glu Ala Gly Val Gln Gly Leu Ser 
            20                  25                  30          


Ala Gly Asp Asp Ser Gly Thr Met Ser Gln Asp Thr Glu Val Asp Met 
        35                  40                  45              


Lys Glu Val Glu Leu Asn Glu Leu Glu Pro Glu Lys Gln Pro Met Asn 
    50                  55                  60                  


Ala Ala Ser Gly Ala Ala Met Ser Leu Ala Gly Ala Glu Lys Asn Gly 
65                  70                  75                  80  


Leu Val Lys Ile Lys Val Ala Glu Asp Glu Ala Glu Ala Ala Ala Ala 
                85                  90                  95      


Ala Lys Phe Thr Gly Leu Ser Lys Glu Glu Leu Leu Lys Val Ala Gly 
            100                 105                 110         


Ser Pro Gly Trp Val Arg Thr Arg Trp Ala Leu Leu Leu Leu Phe Trp 
        115                 120                 125             


Leu Gly Trp Leu Gly Met Leu Ala Gly Ala Val Val Ile Ile Val Arg 
    130                 135                 140                 


Ala Pro Arg Cys Arg Glu Leu Pro Ala Gln Lys Trp Trp His Thr Gly 
145                 150                 155                 160 


Ala Leu Tyr Arg Ile Gly Asp Leu Gln Ala Phe Gln Gly His Gly Ala 
                165                 170                 175     


Gly Asn Leu Ala Gly Leu Lys Gly Arg Leu Asp Tyr Leu Ser Ser Leu 
            180                 185                 190         


Lys Val Lys Gly Leu Val Leu Gly Pro Ile His Lys Asn Gln Lys Asp 
        195                 200                 205             


Asp Val Ala Gln Thr Asp Leu Leu Gln Ile Asp Pro Asn Phe Gly Ser 
    210                 215                 220                 


Lys Glu Asp Phe Asp Ser Leu Leu Gln Ser Ala Lys Lys Lys Ser Ile 
225                 230                 235                 240 


Arg Val Ile Leu Asp Leu Thr Pro Asn Tyr Arg Gly Glu Asn Ser Trp 
                245                 250                 255     


Phe Ser Thr Gln Val Asp Thr Val Ala Thr Lys Val Lys Asp Ala Leu 
            260                 265                 270         


Glu Phe Trp Leu Gln Ala Gly Val Asp Gly Phe Gln Val Arg Asp Ile 
        275                 280                 285             


Glu Asn Leu Lys Asp Ala Ser Ser Phe Leu Ala Glu Trp Gln Asn Ile 
    290                 295                 300                 


Thr Lys Gly Phe Ser Glu Asp Arg Leu Leu Ile Ala Gly Thr Asn Ser 
305                 310                 315                 320 


Ser Asp Leu Gln Gln Ile Leu Ser Leu Leu Glu Ser Asn Lys Asp Leu 
                325                 330                 335     


Leu Leu Thr Ser Ser Tyr Leu Ser Asp Ser Gly Ser Thr Gly Glu His 
            340                 345                 350         


Thr Lys Ser Leu Val Thr Gln Tyr Leu Asn Ala Thr Gly Asn Arg Trp 
        355                 360                 365             


Cys Ser Trp Ser Leu Ser Gln Ala Arg Leu Leu Thr Ser Phe Leu Pro 
    370                 375                 380                 


Ala Gln Leu Leu Arg Leu Tyr Gln Leu Met Leu Phe Thr Leu Pro Gly 
385                 390                 395                 400 


Thr Pro Val Phe Ser Tyr Gly Asp Glu Ile Gly Leu Asp Ala Ala Ala 
                405                 410                 415     


Leu Pro Gly Gln Pro Met Glu Ala Pro Val Met Leu Trp Asp Glu Ser 
            420                 425                 430         


Ser Phe Pro Asp Ile Pro Gly Ala Val Ser Ala Asn Met Thr Val Lys 
        435                 440                 445             


Gly Gln Ser Glu Asp Pro Gly Ser Leu Leu Ser Leu Phe Arg Arg Leu 
    450                 455                 460                 


Ser Asp Gln Arg Ser Lys Glu Arg Ser Leu Leu His Gly Asp Phe His 
465                 470                 475                 480 


Ala Phe Ser Ala Gly Pro Gly Leu Phe Ser Tyr Ile Arg His Trp Asp 
                485                 490                 495     


Gln Asn Glu Arg Phe Leu Val Val Leu Asn Phe Gly Asp Val Gly Leu 
            500                 505                 510         


Ser Ala Gly Leu Gln Ala Ser Asp Leu Pro Ala Ser Ala Ser Leu Pro 
        515                 520                 525             


Ala Lys Ala Asp Leu Leu Leu Ser Thr Gln Pro Gly Arg Glu Glu Gly 
    530                 535                 540                 


Ser Pro Leu Glu Leu Glu Arg Leu Lys Leu Glu Pro His Glu Gly Leu 
545                 550                 555                 560 


Leu Leu Arg Phe Pro Tyr Ala Ala 
                565             


<210>  604
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  604

Met Ala Glu Thr Ser Ala Leu Pro Thr Gly Phe Gly Glu Leu Glu Val 
1               5                   10                  15      


Leu Ala Val Gly Met Val Leu Leu Val Glu Ala Leu Ser Gly Leu Ser 
            20                  25                  30          


Leu Asn Thr Leu Thr Ile Phe Ser Phe Cys Lys Thr Pro Glu Leu Arg 
        35                  40                  45              


Thr Pro Cys His Leu Leu Val Leu Ser Leu Ala Leu Ala Asp Ser Gly 
    50                  55                  60                  


Ile Ser Leu Asn Ala Leu Val Ala Ala Thr Ser Ser Leu Leu Arg Arg 
65                  70                  75                  80  


Trp Pro Tyr Gly Ser Asp Gly Cys Gln Ala His Gly Phe Gln Gly Phe 
                85                  90                  95      


Val Thr Ala Leu Ala Ser Ile Cys Ser Ser Ala Ala Ile Ala Trp Gly 
            100                 105                 110         


Arg Tyr His His Tyr Cys Thr Arg Ser Gln Leu Ala Trp Asn Ser Ala 
        115                 120                 125             


Val Ser Leu Val Leu Phe Val Trp Leu Ser Ser Ala Phe Trp Ala Ala 
    130                 135                 140                 


Leu Pro Leu Leu Gly Trp Gly His Tyr Asp Tyr Glu Pro Leu Gly Thr 
145                 150                 155                 160 


Cys Cys Thr Leu Asp Tyr Ser Lys Gly Asp Arg Asn Phe Thr Ser Phe 
                165                 170                 175     


Leu Phe Thr Met Ser Phe Phe Asn Phe Ala Met Pro Leu Phe Ile Thr 
            180                 185                 190         


Ile Thr Ser Tyr Ser Leu Met Glu Gln Lys Leu Gly Lys Ser Gly His 
        195                 200                 205             


Leu Gln Val Asn Thr Thr Leu Pro Ala Arg Thr Leu Leu Leu Gly Trp 
    210                 215                 220                 


Gly Pro Tyr Ala Ile Leu Tyr Leu Tyr Ala Val Ile Ala Asp Val Thr 
225                 230                 235                 240 


Ser Ile Ser Pro Lys Leu Gln Met Val Pro Ala Leu Ile Ala Lys Met 
                245                 250                 255     


Val Pro Thr Ile Asn Ala Ile Asn Tyr Ala Leu Gly Asn Glu Met Val 
            260                 265                 270         


Cys Arg Gly Ile Trp Gln Cys Leu Ser Pro Gln Lys Arg Glu Lys Asp 
        275                 280                 285             


Arg Thr Lys 
    290     


<210>  605
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  605

Met Ala Glu Thr Ser Ala Leu Pro Thr Gly Phe Gly Glu Leu Glu Val 
1               5                   10                  15      


Leu Ala Val Gly Met Val Leu Leu Val Glu Ala Leu Ser Gly Leu Ser 
            20                  25                  30          


Leu Asn Thr Leu Thr Ile Phe Ser Phe Cys Lys Thr Pro Glu Leu Arg 
        35                  40                  45              


Thr Pro Cys His Leu Leu Val Leu Ser Leu Ala Leu Ala Asp Ser Gly 
    50                  55                  60                  


Ile Ser Leu Asn Ala Leu Val Ala Ala Thr Ser Ser Leu Leu Arg Arg 
65                  70                  75                  80  


Trp Pro Tyr Gly Ser Asp Gly Cys Gln Ala His Gly Phe Gln Gly Phe 
                85                  90                  95      


Val Thr Ala Leu Ala Ser Ile Cys Ser Ser Ala Ala Ile Ala Trp Gly 
            100                 105                 110         


Arg Tyr His His Tyr Cys Thr Arg Ser Gln Leu Ala Trp Asn Ser Ala 
        115                 120                 125             


Val Ser Leu Val Leu Phe Val Trp Leu Ser Ser Ala Phe Trp Ala Ala 
    130                 135                 140                 


Leu Pro Leu Leu Gly Trp Gly His Tyr Asp Tyr Glu Pro Leu Gly Thr 
145                 150                 155                 160 


Cys Cys Thr Leu Asp Tyr Ser Lys Gly Asp Arg Asn Phe Thr Ser Phe 
                165                 170                 175     


Leu Phe Thr Met Ser Phe Phe Asn Phe Ala Met Pro Leu Phe Ile Thr 
            180                 185                 190         


Ile Thr Ser Tyr Ser Leu Met Glu Gln Lys Leu Gly Lys Ser Gly His 
        195                 200                 205             


Leu Gln Val Pro Ala Leu Ile Ala Lys Met Val Pro Thr Ile Asn Ala 
    210                 215                 220                 


Ile Asn Tyr Ala Leu Gly Asn Glu Met Val Cys Arg Gly Ile Trp Gln 
225                 230                 235                 240 


Cys Leu Ser Pro Gln Lys Arg Glu Lys Asp Arg Thr Lys 
                245                 250             


<210>  606
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  606

Met Glu Leu Trp Pro Cys Leu Ala Ala Ala Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Gln Leu Ser Arg Ala Ala Glu Phe Tyr Ala Lys Val Ala Leu 
            20                  25                  30          


Tyr Cys Ala Leu Cys Phe Thr Val Ser Ala Val Ala Ser Leu Val Cys 
        35                  40                  45              


Leu Leu Arg His Gly Gly Arg Thr Val Glu Asn Met Ser Ile Ile Gly 
    50                  55                  60                  


Trp Phe Val Arg Ser Phe Lys Tyr Phe Tyr Gly Leu Arg Phe Glu Val 
65                  70                  75                  80  


Arg Asp Pro Arg Arg Leu Gln Glu Ala Arg Pro Cys Val Ile Val Ser 
                85                  90                  95      


Asn His Gln Ser Ile Leu Asp Met Met Gly Leu Met Glu Val Leu Pro 
            100                 105                 110         


Glu Arg Cys Val Gln Ile Ala Lys Arg Glu Leu Leu Phe Leu Gly Pro 
        115                 120                 125             


Val Gly Leu Ile Met Tyr Leu Gly Gly Val Phe Phe Ile Asn Arg Gln 
    130                 135                 140                 


Arg Ser Ser Thr Ala Met Thr Val Met Ala Asp Leu Gly Glu Arg Met 
145                 150                 155                 160 


Val Arg Glu Asn Val Pro Ile Val Pro Val Val Tyr Ser Ser Phe Ser 
                165                 170                 175     


Ser Phe Tyr Asn Thr Lys Lys Lys Phe Phe Thr Ser Gly Thr Val Thr 
            180                 185                 190         


Val Gln Val Leu Glu Ala Ile Pro Thr Ser Gly Leu Thr Ala Ala Asp 
        195                 200                 205             


Val Pro Ala Leu Val Asp Thr Cys His Arg Ala Met Arg Thr Thr Phe 
    210                 215                 220                 


Leu His Ile Ser Lys Thr Pro Gln Glu Asn Gly Ala Thr Ala Gly Ser 
225                 230                 235                 240 


Gly Val Gln Pro Ala Gln 
                245     


<210>  607
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  607

Met Ala Asn Ser Ala Ser Pro Glu Gln Asn Gln Asn His Cys Ser Ala 
1               5                   10                  15      


Ile Asn Asn Ser Ile Pro Leu Met Gln Gly Asn Leu Pro Thr Leu Thr 
            20                  25                  30          


Leu Ser Gly Lys Ile Arg Val Thr Val Thr Phe Phe Leu Phe Leu Leu 
        35                  40                  45              


Ser Ala Thr Phe Asn Ala Ser Phe Leu Leu Lys Leu Gln Lys Trp Thr 
    50                  55                  60                  


Gln Lys Lys Glu Lys Gly Lys Lys Leu Ser Arg Met Lys Leu Leu Leu 
65                  70                  75                  80  


Lys His Leu Thr Leu Ala Asn Leu Leu Glu Thr Leu Ile Val Met Pro 
                85                  90                  95      


Leu Asp Gly Met Trp Asn Ile Thr Val Gln Trp Tyr Ala Gly Glu Leu 
            100                 105                 110         


Leu Cys Lys Val Leu Ser Tyr Leu Lys Leu Phe Ser Met Tyr Ala Pro 
        115                 120                 125             


Ala Phe Met Met Val Val Ile Ser Leu Asp Arg Ser Leu Ala Ile Thr 
    130                 135                 140                 


Arg Pro Leu Ala Leu Lys Ser Asn Ser Lys Val Gly Gln Ser Met Val 
145                 150                 155                 160 


Gly Leu Ala Trp Ile Leu Ser Ser Val Phe Ala Gly Pro Gln Leu Pro 
                165                 170                 175     


Leu His His Pro Ser Phe His His Ala Asp Leu Gln Cys Lys Asn His 
            180                 185                 190         


Leu His Pro Asp Thr Gly Pro Ser Ser Gly Pro Pro Arg Thr Thr Thr 
        195                 200                 205             


Glu Ser Val Gln Glu Gln Tyr Thr Lys Ser Thr Ala Glu Asp Ser Lys 
    210                 215                 220                 


Asn Asp Gly Cys Ile Cys His Phe Ile Tyr Cys Leu Leu Asp Ser Leu 
225                 230                 235                 240 


Leu Cys Pro Arg Asn Leu Val Leu Val 
                245                 


<210>  608
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  608

Met Trp Thr Leu Lys Ser Ser Leu Val Leu Leu Leu Cys Leu Thr Cys 
1               5                   10                  15      


Ser Tyr Ala Phe Met Phe Ser Ser Leu Arg Gln Lys Thr Ser Glu Pro 
            20                  25                  30          


Gln Gly Lys Val Gln Tyr Gly Glu His Phe Arg Ile Arg Gln Asn Leu 
        35                  40                  45              


Pro Glu His Thr Gln Gly Trp Leu Gly Ser Lys Trp Leu Trp Leu Leu 
    50                  55                  60                  


Phe Val Val Val Pro Phe Val Ile Leu Gln Cys Gln Arg Asp Ser Glu 
65                  70                  75                  80  


Lys Asn Lys Glu Gln Ser Pro Pro Gly Leu Arg Gly Gly Gln Leu His 
                85                  90                  95      


Ser Pro Leu Lys Lys Lys Arg Asn Ala Ser Pro Asn Lys Asp Cys Ala 
            100                 105                 110         


Phe Asn Thr Leu Met Glu Leu Glu Val Glu Leu Met Lys Phe Val Ser 
        115                 120                 125             


Lys Val Arg Asn Leu Lys Arg Ala Met Ala Thr Gly Ser Gly Ser Asn 
    130                 135                 140                 


Leu Arg Leu Arg Lys Ser Glu Met Pro Ala Asp Pro Tyr His Val Thr 
145                 150                 155                 160 


Ile Cys Glu Ile Trp Gly Glu Glu Ser Ser Ser 
                165                 170     


<210>  609
<211>  1198
<212>  PRT
<213>  Homo sapiens

<400>  609

Met Gly Lys Val Gly Ala Gly Gly Gly Ser Gln Ala Arg Leu Ser Ala 
1               5                   10                  15      


Leu Leu Ala Gly Ala Gly Leu Leu Ile Leu Cys Ala Pro Gly Val Cys 
            20                  25                  30          


Gly Gly Gly Ser Cys Cys Pro Ser Pro His Pro Ser Ser Ala Pro Arg 
        35                  40                  45              


Ser Ala Ser Thr Pro Arg Gly Phe Ser His Gln Gly Arg Pro Gly Arg 
    50                  55                  60                  


Ala Pro Ala Thr Pro Leu Pro Leu Val Val Arg Pro Leu Phe Ser Val 
65                  70                  75                  80  


Ala Pro Gly Asp Arg Ala Leu Ser Leu Glu Arg Ala Arg Gly Thr Gly 
                85                  90                  95      


Ala Ser Met Ala Val Ala Ala Arg Ser Gly Arg Arg Arg Arg Ser Gly 
            100                 105                 110         


Ala Asp Gln Glu Lys Ala Glu Arg Gly Glu Gly Ala Ser Arg Ser Pro 
        115                 120                 125             


Arg Gly Val Leu Arg Asp Gly Gly Gln Gln Glu Pro Gly Thr Arg Glu 
    130                 135                 140                 


Arg Asp Pro Asp Lys Ala Thr Arg Phe Arg Met Glu Glu Leu Arg Leu 
145                 150                 155                 160 


Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala 
                165                 170                 175     


Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile Leu Thr 
            180                 185                 190         


Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp 
        195                 200                 205             


Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Val 
    210                 215                 220                 


Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys 
225                 230                 235                 240 


Arg Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser Leu Leu 
                245                 250                 255     


Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe 
            260                 265                 270         


Tyr Ile Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu 
        275                 280                 285             


Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe Gly Arg 
    290                 295                 300                 


Arg Trp Gln Leu Ile Gln Glu Gly Val Val Pro Asn Arg Phe Tyr Trp 
305                 310                 315                 320 


Ser Val Met Gly Ser Asn Lys Glu Pro Asp Leu Val His Leu Glu Ala 
                325                 330                 335     


Arg Thr Val Asp Gly His Ser His Tyr Leu Thr Cys Arg Met Gln Asn 
            340                 345                 350         


Cys Thr Glu Ala Asn Arg Asn Gln Pro Phe Pro Gly Tyr Ile Asp Pro 
        355                 360                 365             


Asp Ser Leu Ile Val Gln Asp His Tyr Val Phe Val Gln Leu Thr Ser 
    370                 375                 380                 


Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Asn Ala Phe Ala 
385                 390                 395                 400 


Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His Val Ile 
                405                 410                 415     


Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln 
            420                 425                 430         


Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe 
        435                 440                 445             


Thr Leu Ala Leu Glu Asn Val Gln Ser Ser Arg Gly Pro Glu Gly Asn 
    450                 455                 460                 


Ile Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu 
465                 470                 475                 480 


Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn 
                485                 490                 495     


Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Thr Asp Leu Arg 
            500                 505                 510         


Gly Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His Leu His 
        515                 520                 525             


Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala Ser Lys 
    530                 535                 540                 


Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Ser Glu 
545                 550                 555                 560 


Leu Ser Asp Thr Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn 
                565                 570                 575     


Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Val Leu Tyr Leu Asp 
            580                 585                 590         


Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro Ile Arg 
        595                 600                 605             


His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys Tyr Ser 
    610                 615                 620                 


Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu Pro Gly 
625                 630                 635                 640 


Glu Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His Arg Ser 
                645                 650                 655     


Glu Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp Arg Arg 
            660                 665                 670         


Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln Gly Glu 
        675                 680                 685             


Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu 
    690                 695                 700                 


Arg Lys Cys Met Gln Gly Lys Tyr Ala Gly Ala Met Glu Ser Glu Pro 
705                 710                 715                 720 


Cys Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg 
                725                 730                 735     


His Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser 
            740                 745                 750         


Leu Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Thr Gly 
        755                 760                 765             


Tyr Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln 
    770                 775                 780                 


Tyr Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu 
785                 790                 795                 800 


Arg Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn 
                805                 810                 815     


Val Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr Leu 
            820                 825                 830         


Ile Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn Leu 
        835                 840                 845             


Ser Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly Ile 
    850                 855                 860                 


Phe Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser Ala 
865                 870                 875                 880 


Val Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser 
                885                 890                 895     


Leu Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val 
            900                 905                 910         


Leu Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr Gly 
        915                 920                 925             


Asn Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe Arg 
    930                 935                 940                 


Phe Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly 
945                 950                 955                 960 


Asn Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu Phe 
                965                 970                 975     


Arg Ser Leu Arg Leu Ser Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro 
            980                 985                 990         


Asp Ile Pro Glu Trp Arg Arg Asp  Ile Gly Arg Val Ile  Lys Lys Ser 
        995                 1000                 1005             


Leu Val  Glu Ala Thr Gly Val  Pro Gly Gln His Ile  Leu Val Ala 
    1010                 1015                 1020             


Val Leu  Pro Gly Leu Pro Thr  Thr Ala Glu Leu Phe  Val Leu Pro 
    1025                 1030                 1035             


Tyr Gln  Asp Pro Ala Gly Glu  Asn Lys Arg Ser Thr  Asp Asp Leu 
    1040                 1045                 1050             


Glu Gln  Ile Ser Glu Leu Leu  Ile His Thr Leu Asn  Gln Asn Ser 
    1055                 1060                 1065             


Val His  Phe Glu Leu Lys Pro  Gly Val Arg Val Leu  Val His Ala 
    1070                 1075                 1080             


Ala His  Leu Thr Ala Ala Pro  Leu Val Asp Leu Thr  Pro Thr His 
    1085                 1090                 1095             


Ser Gly  Ser Ala Met Leu Met  Leu Leu Ser Val Val  Phe Val Gly 
    1100                 1105                 1110             


Leu Ala  Val Phe Val Ile Tyr  Lys Phe Lys Arg Lys  Ile Pro Gly 
    1115                 1120                 1125             


Ile Asn  Val Tyr Ala Gln Met  Gln Asn Glu Lys Glu  Gln Glu Met 
    1130                 1135                 1140             


Ile Ser  Pro Val Ser His Ser  Glu Ser Arg Pro Asn  Val Pro Gln 
    1145                 1150                 1155             


Thr Glu  Leu Arg Arg Pro Gly  Gln Leu Ile Asp Glu  Lys Val Glu 
    1160                 1165                 1170             


Ser Gln  Leu Ile Gly Ser Ile  Ser Ile Val Ala Glu  Asn Gln Ser 
    1175                 1180                 1185             


Thr Lys  Glu Ile Pro Thr Tyr  Val Asn Val 
    1190                 1195             


<210>  610
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  610

Met Ser Gln Asp Thr Glu Val Asp Met Lys Glu Val Glu Leu Asn Glu 
1               5                   10                  15      


Leu Glu Pro Glu Lys Gln Pro Met Asn Ala Ala Ser Gly Ala Ala Met 
            20                  25                  30          


Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu Val Lys Ile Lys Val Ala 
        35                  40                  45              


Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala Lys Phe Thr Gly Leu Ser 
    50                  55                  60                  


Lys Glu Glu Leu Leu Lys Val Ala Gly Ser Pro Gly Trp Val Arg Thr 
65                  70                  75                  80  


Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly Trp Leu Gly Met Leu 
                85                  90                  95      


Ala Gly Ala Val Val Ile Ile Val Arg Ala Pro Arg Cys Arg Glu Leu 
            100                 105                 110         


Pro Ala Gln Lys Trp Trp His Thr Gly Ala Leu Tyr Arg Ile Gly Asp 
        115                 120                 125             


Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn Leu Ala Gly Leu Lys 
    130                 135                 140                 


Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val Lys Gly Leu Val Leu 
145                 150                 155                 160 


Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val Ala Gln Thr Asp Leu 
                165                 170                 175     


Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu Asp Phe Asp Ser Leu 
            180                 185                 190         


Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg Val Ile Leu Asp Leu Thr 
        195                 200                 205             


Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe Ser Thr Gln Val Asp Thr 
    210                 215                 220                 


Val Ala Thr Lys Val Lys Asp Ala Leu Glu Phe Trp Leu Gln Ala Gly 
225                 230                 235                 240 


Val Asp Gly Phe Gln Val Arg Asp Ile Glu Asn Leu Lys Asp Ala Ser 
                245                 250                 255     


Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys Gly Phe Ser Glu Asp 
            260                 265                 270         


Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp Leu Gln Gln Ile Leu 
        275                 280                 285             


Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu Thr Ser Ser Tyr Leu 
    290                 295                 300                 


Ser Asp Ser Gly Ser Thr Gly Glu His Thr Lys Ser Leu Val Thr Gln 
305                 310                 315                 320 


Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser Trp Ser Leu Ser Gln 
                325                 330                 335     


Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln Leu Leu Arg Leu Tyr 
            340                 345                 350         


Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro Val Phe Ser Tyr Gly 
        355                 360                 365             


Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu Pro Gly Gln Pro Met Glu 
    370                 375                 380                 


Ala Pro Val Met Leu Trp Asp Glu Ser Ser Phe Pro Asp Ile Pro Gly 
385                 390                 395                 400 


Ala Val Ser Ala Asn Met Thr Val Lys Gly Gln Ser Glu Asp Pro Gly 
                405                 410                 415     


Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser Asp Gln Arg Ser Lys Glu 
            420                 425                 430         


Arg Ser Leu Leu His Gly Asp Phe His Ala Phe Ser Ala Gly Pro Gly 
        435                 440                 445             


Leu Phe Ser Tyr Ile Arg His Trp Asp Gln Asn Glu Arg Phe Leu Val 
    450                 455                 460                 


Val Leu Asn Phe Gly Asp Val Gly Leu Ser Ala Gly Leu Gln Ala Ser 
465                 470                 475                 480 


Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala Lys Ala Asp Leu Leu Leu 
                485                 490                 495     


Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser Pro Leu Glu Leu Glu Arg 
            500                 505                 510         


Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu Arg Phe Pro Tyr Ala 
        515                 520                 525             


Ala 
    


<210>  611
<211>  588
<212>  PRT
<213>  Homo sapiens

<400>  611

Met Glu Pro Pro Asp Ala Pro Ala Gln Ala Arg Gly Ala Pro Arg Leu 
1               5                   10                  15      


Leu Leu Leu Ala Val Leu Leu Ala Ala His Pro Asp Ala Gln Ala Glu 
            20                  25                  30          


Val Arg Leu Ser Val Pro Pro Leu Val Glu Val Met Arg Gly Lys Ser 
        35                  40                  45              


Val Ile Leu Asp Cys Thr Pro Thr Gly Thr His Asp His Tyr Met Leu 
    50                  55                  60                  


Glu Trp Phe Leu Thr Asp Arg Ser Gly Ala Arg Pro Arg Leu Ala Ser 
65                  70                  75                  80  


Ala Glu Met Gln Gly Ser Glu Leu Gln Val Thr Met His Asp Thr Arg 
                85                  90                  95      


Gly Arg Ser Pro Pro Tyr Gln Leu Asp Ser Gln Gly Arg Leu Val Leu 
            100                 105                 110         


Ala Glu Ala Gln Val Gly Asp Glu Arg Asp Tyr Val Cys Val Val Arg 
        115                 120                 125             


Ala Gly Ala Ala Gly Thr Ala Glu Ala Thr Ala Arg Leu Asn Val Phe 
    130                 135                 140                 


Ala Lys Pro Glu Ala Thr Glu Val Ser Pro Asn Lys Gly Thr Leu Ser 
145                 150                 155                 160 


Val Met Glu Asp Ser Ala Gln Glu Ile Ala Thr Cys Asn Ser Arg Asn 
                165                 170                 175     


Gly Asn Pro Ala Pro Lys Ile Thr Trp Tyr Arg Asn Gly Gln Arg Leu 
            180                 185                 190         


Glu Val Pro Val Glu Met Asn Pro Glu Gly Tyr Met Thr Ser Arg Thr 
        195                 200                 205             


Val Arg Glu Ala Ser Gly Leu Leu Ser Leu Thr Ser Thr Leu Tyr Leu 
    210                 215                 220                 


Arg Leu Arg Lys Asp Asp Arg Asp Ala Ser Phe His Cys Ala Ala His 
225                 230                 235                 240 


Tyr Ser Leu Pro Glu Gly Arg His Gly Arg Leu Asp Ser Pro Thr Phe 
                245                 250                 255     


His Leu Thr Leu His Tyr Pro Thr Glu His Val Gln Phe Trp Val Gly 
            260                 265                 270         


Ser Pro Ser Thr Pro Ala Gly Trp Val Arg Glu Gly Asp Thr Val Gln 
        275                 280                 285             


Leu Leu Cys Arg Gly Asp Gly Ser Pro Ser Pro Glu Tyr Thr Leu Phe 
    290                 295                 300                 


Arg Leu Gln Asp Glu Gln Glu Glu Val Leu Asn Val Asn Leu Glu Gly 
305                 310                 315                 320 


Asn Leu Thr Leu Glu Gly Val Thr Arg Gly Gln Ser Gly Thr Tyr Gly 
                325                 330                 335     


Cys Arg Val Glu Asp Tyr Asp Ala Ala Asp Asp Val Gln Leu Ser Lys 
            340                 345                 350         


Thr Leu Glu Leu Arg Val Ala Tyr Leu Asp Pro Leu Glu Leu Ser Glu 
        355                 360                 365             


Gly Lys Val Leu Ser Leu Pro Leu Asn Ser Ser Ala Val Val Asn Cys 
    370                 375                 380                 


Ser Val His Gly Leu Pro Thr Pro Ala Leu Arg Trp Thr Lys Asp Ser 
385                 390                 395                 400 


Thr Pro Leu Gly Asp Gly Pro Met Leu Ser Leu Ser Ser Ile Thr Phe 
                405                 410                 415     


Asp Ser Asn Gly Thr Tyr Val Cys Glu Ala Ser Leu Pro Thr Val Pro 
            420                 425                 430         


Val Leu Ser Arg Thr Gln Asn Phe Thr Leu Leu Val Gln Gly Ser Pro 
        435                 440                 445             


Glu Leu Lys Thr Ala Glu Ile Glu Pro Lys Ala Asp Gly Ser Trp Arg 
    450                 455                 460                 


Glu Gly Asp Glu Val Thr Leu Ile Cys Ser Ala Arg Gly His Pro Asp 
465                 470                 475                 480 


Pro Lys Leu Ser Trp Ser Gln Leu Gly Gly Ser Pro Ala Glu Pro Ile 
                485                 490                 495     


Pro Gly Arg Gln Gly Trp Val Ser Ser Ser Leu Thr Leu Lys Val Thr 
            500                 505                 510         


Ser Ala Leu Ser Arg Asp Gly Ile Ser Cys Glu Ala Ser Asn Pro His 
        515                 520                 525             


Gly Asn Lys Arg His Val Phe His Phe Gly Thr Val Ser Pro Gln Thr 
    530                 535                 540                 


Ser Gln Ala Gly Val Ala Val Met Ala Val Ala Val Ser Val Gly Leu 
545                 550                 555                 560 


Leu Leu Leu Val Val Ala Val Phe Tyr Cys Val Arg Arg Lys Gly Gly 
                565                 570                 575     


Pro Cys Cys Arg Gln Arg Arg Glu Lys Gly Ala Pro 
            580                 585             


<210>  612
<211>  589
<212>  PRT
<213>  Homo sapiens

<400>  612

Met Ser Lys Pro Gly Lys Pro Thr Leu Asn His Gly Leu Val Pro Val 
1               5                   10                  15      


Asp Leu Lys Ser Ala Lys Glu Pro Leu Pro His Gln Thr Val Met Lys 
            20                  25                  30          


Ile Phe Ser Ile Ser Ile Ile Ala Gln Gly Leu Pro Phe Cys Arg Arg 
        35                  40                  45              


Arg Met Lys Arg Lys Leu Asp His Gly Ser Glu Val Arg Ser Phe Ser 
    50                  55                  60                  


Leu Gly Lys Lys Pro Cys Lys Val Ser Glu Tyr Thr Ser Thr Thr Gly 
65                  70                  75                  80  


Leu Val Pro Cys Ser Ala Thr Pro Thr Thr Phe Gly Asp Leu Arg Ala 
                85                  90                  95      


Ala Asn Gly Gln Gly Gln Gln Arg Arg Arg Ile Thr Ser Val Gln Pro 
            100                 105                 110         


Pro Thr Gly Leu Gln Glu Trp Leu Lys Met Phe Gln Ser Trp Ser Gly 
        115                 120                 125             


Pro Glu Lys Leu Leu Ala Leu Asp Glu Leu Ile Asp Ser Cys Glu Pro 
    130                 135                 140                 


Thr Gln Val Lys His Met Met Gln Val Ile Glu Pro Gln Phe Gln Arg 
145                 150                 155                 160 


Asp Phe Ile Ser Leu Leu Pro Lys Glu Leu Ala Leu Tyr Val Leu Ser 
                165                 170                 175     


Phe Leu Glu Pro Lys Asp Leu Leu Gln Ala Ala Gln Thr Cys Arg Tyr 
            180                 185                 190         


Trp Arg Ile Leu Ala Glu Asp Asn Leu Leu Trp Arg Glu Lys Cys Lys 
        195                 200                 205             


Glu Glu Gly Ile Asp Glu Pro Leu His Ile Lys Arg Arg Lys Val Ile 
    210                 215                 220                 


Lys Pro Gly Phe Ile His Ser Pro Trp Lys Ser Ala Tyr Ile Arg Gln 
225                 230                 235                 240 


His Arg Ile Asp Thr Asn Trp Arg Arg Gly Glu Leu Lys Ser Pro Lys 
                245                 250                 255     


Val Leu Lys Gly His Asp Asp His Val Ile Thr Cys Leu Gln Phe Cys 
            260                 265                 270         


Gly Asn Arg Ile Val Ser Gly Ser Asp Asp Asn Thr Leu Lys Val Trp 
        275                 280                 285             


Ser Ala Val Thr Gly Lys Cys Leu Arg Thr Leu Val Gly His Thr Gly 
    290                 295                 300                 


Gly Val Trp Ser Ser Gln Met Arg Asp Asn Ile Ile Ile Ser Gly Ser 
305                 310                 315                 320 


Thr Asp Arg Thr Leu Lys Val Trp Asn Ala Glu Thr Gly Glu Cys Ile 
                325                 330                 335     


His Thr Leu Tyr Gly His Thr Ser Thr Val Arg Cys Met His Leu His 
            340                 345                 350         


Glu Lys Arg Val Val Ser Gly Ser Arg Asp Ala Thr Leu Arg Val Trp 
        355                 360                 365             


Asp Ile Glu Thr Gly Gln Cys Leu His Val Leu Met Gly His Val Ala 
    370                 375                 380                 


Ala Val Arg Cys Val Gln Tyr Asp Gly Arg Arg Val Val Ser Gly Ala 
385                 390                 395                 400 


Tyr Asp Phe Met Val Lys Val Trp Asp Pro Glu Thr Glu Thr Cys Leu 
                405                 410                 415     


His Thr Leu Gln Gly His Thr Asn Arg Val Tyr Ser Leu Gln Phe Asp 
            420                 425                 430         


Gly Ile His Val Val Ser Gly Ser Leu Asp Thr Ser Ile Arg Val Trp 
        435                 440                 445             


Asp Val Glu Thr Gly Asn Cys Ile His Thr Leu Thr Gly His Gln Ser 
    450                 455                 460                 


Leu Thr Ser Gly Met Glu Leu Lys Asp Asn Ile Leu Val Ser Gly Asn 
465                 470                 475                 480 


Ala Asp Ser Thr Val Lys Ile Trp Asp Ile Lys Thr Gly Gln Cys Leu 
                485                 490                 495     


Gln Thr Leu Gln Gly Pro Asn Lys His Gln Ser Ala Val Thr Cys Leu 
            500                 505                 510         


Gln Phe Asn Lys Asn Phe Val Ile Thr Ser Ser Asp Asp Gly Thr Val 
        515                 520                 525             


Lys Leu Trp Asp Leu Lys Thr Gly Glu Phe Ile Arg Asn Leu Val Thr 
    530                 535                 540                 


Leu Glu Ser Gly Gly Ser Gly Gly Val Val Trp Arg Ile Arg Ala Ser 
545                 550                 555                 560 


Asn Thr Lys Leu Val Cys Ala Val Gly Ser Arg Asn Gly Thr Glu Glu 
                565                 570                 575     


Thr Lys Leu Leu Val Leu Asp Phe Asp Val Asp Met Lys 
            580                 585                 


<210>  613
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  613

Met Ala Glu Leu Thr Val Glu Val Arg Gly Ser Asn Gly Ala Phe Tyr 
1               5                   10                  15      


Lys Gly Phe Ile Lys Asp Val His Glu Asp Ser Leu Thr Val Val Phe 
            20                  25                  30          


Glu Asn Asn Trp Gln Pro Glu Arg Gln Val Pro Phe Asn Glu Val Arg 
        35                  40                  45              


Leu Pro Pro Pro Pro Asp Ile Lys Lys Glu Ile Ser Glu Gly Asp Glu 
    50                  55                  60                  


Val Glu Val Tyr Ser Arg Ala Asn Asp Gln Glu Pro Cys Gly Trp Trp 
65                  70                  75                  80  


Leu Ala Lys Val Arg Met Met Lys Gly Glu Phe Tyr Val Ile Glu Tyr 
                85                  90                  95      


Ala Ala Cys Asp Ala Thr Tyr Asn Glu Ile Val Thr Phe Glu Arg Leu 
            100                 105                 110         


Arg Pro Val Asn Gln Asn Lys Thr Val Lys Lys Asn Thr Phe Phe Lys 
        115                 120                 125             


Cys Thr Val Asp Val Pro Glu Asp Leu Arg Glu Ala Cys Ala Asn Glu 
    130                 135                 140                 


Asn Ala His Lys Asp Phe Lys Lys Ala Val Gly Ala Cys Arg Ile Phe 
145                 150                 155                 160 


Tyr His Pro Glu Thr Thr Gln Leu Met Ile Leu Ser Ala Ser Glu Ala 
                165                 170                 175     


Thr Val Lys Arg Val Asn Ile Leu Ser Asp Met His Leu Arg Ser Ile 
            180                 185                 190         


Arg Thr Lys Leu Met Leu Met Ser Arg Asn Glu Glu Ala Thr Lys His 
        195                 200                 205             


Leu Glu Cys Thr Lys Gln Leu Ala Ala Ala Phe His Glu Glu Phe Val 
    210                 215                 220                 


Val Arg Glu Asp Leu Met Gly Leu Ala Ile Gly Thr His Gly Ser Asn 
225                 230                 235                 240 


Ile Gln Gln Ala Arg Lys Val Pro Gly Val Thr Ala Ile Glu Leu Asp 
                245                 250                 255     


Glu Asp Thr Gly Thr Phe Arg Ile Tyr Gly Glu Ser Ala Asp Ala Val 
            260                 265                 270         


Lys Lys Ala Arg Gly Phe Leu Glu Phe Val Glu Asp Phe Ile Gln Val 
        275                 280                 285             


Pro Arg Asn Leu Val Gly Lys Val Ile Gly Lys Asn Gly Lys Val Ile 
    290                 295                 300                 


Gln Glu Ile Val Asp Lys Ser Gly Val Val Arg Val Arg Ile Glu Gly 
305                 310                 315                 320 


Asp Asn Glu Asn Lys Leu Pro Arg Glu Asp Gly Met Val Pro Phe Val 
                325                 330                 335     


Phe Val Gly Thr Lys Glu Ser Ile Gly Asn Val Gln Val Leu Leu Glu 
            340                 345                 350         


Tyr His Ile Ala Tyr Leu Lys Glu Val Glu Gln Leu Arg Met Glu Arg 
        355                 360                 365             


Leu Gln Ile Asp Glu Gln Leu Arg Gln Ile Gly Ser Arg Ser Tyr Ser 
    370                 375                 380                 


Gly Arg Gly Arg Gly Arg Arg Gly Pro Asn Tyr Thr Ser Gly Tyr Gly 
385                 390                 395                 400 


Thr Asn Ser Glu Leu Ser Asn Pro Ser Glu Thr Glu Ser Glu Arg Lys 
                405                 410                 415     


Asp Glu Leu Ser Asp Trp Ser Leu Ala Gly Glu Asp Asp Arg Asp Ser 
            420                 425                 430         


Arg His Gln Arg Asp Ser Arg Arg Arg Pro Gly Gly Arg Gly Arg Ser 
        435                 440                 445             


Val Ser Gly Gly Arg Gly Arg Gly Gly Pro Arg Gly Gly Lys Ser Ser 
    450                 455                 460                 


Ile Ser Ser Val Leu Lys Asp Pro Asp Ser Asn Pro Tyr Ser Leu Leu 
465                 470                 475                 480 


Asp Asn Thr Glu Ser Asp Gln Thr Ala Asp Thr Asp Ala Ser Glu Ser 
                485                 490                 495     


His His Ser Thr Asn Arg Arg Arg Arg Ser Arg Arg Arg Arg Thr Asp 
            500                 505                 510         


Glu Asp Ala Val Leu Met Asp Gly Met Thr Glu Ser Asp Thr Ala Ser 
        515                 520                 525             


Val Asn Glu Asn Gly Leu Gly Lys Arg Cys Asp 
    530                 535                 


<210>  614
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  614

Met Met Lys Gly Glu Phe Tyr Val Ile Glu Tyr Ala Ala Cys Asp Ala 
1               5                   10                  15      


Thr Tyr Asn Glu Ile Val Thr Phe Glu Arg Leu Arg Pro Val Asn Gln 
            20                  25                  30          


Asn Lys Thr Val Lys Lys Asn Thr Phe Phe Lys Cys Thr Val Asp Val 
        35                  40                  45              


Pro Glu Asp Leu Arg Glu Ala Cys Ala Asn Glu Asn Ala His Lys Asp 
    50                  55                  60                  


Phe Lys Lys Ala Val Gly Ala Cys Arg Ile Phe Tyr His Pro Glu Thr 
65                  70                  75                  80  


Thr Gln Leu Met Ile Leu Ser Ala Ser Glu Ala Thr Val Lys Arg Val 
                85                  90                  95      


Asn Ile Leu Ser Asp Met His Leu Arg Ser Ile Arg Thr Lys Leu Met 
            100                 105                 110         


Leu Met Ser Arg Asn Glu Glu Ala Thr Lys His Leu Glu Cys Thr Lys 
        115                 120                 125             


Gln Leu Ala Ala Ala Phe His Glu Glu Phe Val Val Arg Glu Asp Leu 
    130                 135                 140                 


Met Gly Leu Ala Ile Gly Thr His Gly Ser Asn Ile Gln Gln Ala Arg 
145                 150                 155                 160 


Lys Val Pro Gly Val Thr Ala Ile Glu Leu Asp Glu Asp Thr Gly Thr 
                165                 170                 175     


Phe Arg Ile Tyr Gly Glu Ser Ala Asp Ala Val Lys Lys Ala Arg Gly 
            180                 185                 190         


Phe Leu Glu Phe Val Glu Asp Phe Ile Gln Val Pro Arg Asn Leu Val 
        195                 200                 205             


Gly Lys Val Ile Gly Lys Asn Gly Lys Val Ile Gln Glu Ile Val Asp 
    210                 215                 220                 


Lys Ser Gly Val Val Arg Val Arg Ile Glu Gly Asp Asn Glu Asn Lys 
225                 230                 235                 240 


Leu Pro Arg Glu Asp Gly Met Val Pro Phe Val Phe Val Gly Thr Lys 
                245                 250                 255     


Glu Ser Ile Gly Asn Val Gln Val Leu Leu Glu Tyr His Ile Ala Tyr 
            260                 265                 270         


Leu Lys Glu Val Glu Gln Leu Arg Met Glu Arg Leu Gln Ile Asp Glu 
        275                 280                 285             


Gln Leu Arg Gln Ile Gly Ser Arg Ser Tyr Ser Gly Arg Gly Arg Gly 
    290                 295                 300                 


Arg Arg Gly Pro Asn Tyr Thr Ser Gly Tyr Gly Thr Asn Ser Glu Leu 
305                 310                 315                 320 


Ser Asn Pro Ser Glu Thr Glu Ser Glu Arg Lys Asp Glu Leu Ser Asp 
                325                 330                 335     


Trp Ser Leu Ala Gly Glu Asp Asp Arg Asp Ser Arg His Gln Arg Asp 
            340                 345                 350         


Ser Arg Arg Arg Pro Gly Gly Arg Gly Arg Ser Val Ser Gly Gly Arg 
        355                 360                 365             


Gly Arg Gly Gly Pro Arg Gly Gly Lys Ser Ser Ile Ser Ser Val Leu 
    370                 375                 380                 


Lys Asp Pro Asp Ser Asn Pro Tyr Ser Leu Leu Asp Asn Thr Glu Ser 
385                 390                 395                 400 


Asp Gln Thr Ala Asp Thr Asp Ala Ser Glu Ser His His Ser Thr Asn 
                405                 410                 415     


Arg Arg Arg Arg Ser Arg Arg Arg Arg Thr Asp Glu Asp Ala Val Leu 
            420                 425                 430         


Met Asp Gly Met Thr Glu Ser Asp Thr Ala Ser Val Asn Glu Asn Gly 
        435                 440                 445             


Leu Val Thr Val Ala Asp Tyr Ile Ser Arg Ala Glu Ser Gln Ser Arg 
    450                 455                 460                 


Gln Arg Asn Leu Pro Arg Glu Thr Leu Ala Lys Asn Lys Lys Glu Met 
465                 470                 475                 480 


Ala Lys Asp Val Ile Glu Glu His Gly Pro Ser Glu Lys Ala Ile Asn 
                485                 490                 495     


Gly Pro Thr Ser Ala Ser Gly Asp Asp Ile Ser Lys Leu Gln Arg Thr 
            500                 505                 510         


Pro Gly Glu Glu Lys Ile Asn Thr Leu Lys Glu Glu Asn Thr Gln Glu 
        515                 520                 525             


Ala Ala Val Leu Asn Gly Val Ser 
    530                 535     


<210>  615
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  615

Met Ala His Ser Lys Gln Pro Ser His Phe Gln Ser Leu Met Leu Leu 
1               5                   10                  15      


Gln Trp Pro Leu Ser Tyr Leu Ala Ile Phe Trp Ile Leu Gln Pro Leu 
            20                  25                  30          


Phe Val Tyr Leu Leu Phe Thr Ser Leu Trp Pro Leu Pro Val Leu Tyr 
        35                  40                  45              


Phe Ala Trp Leu Phe Leu Asp Trp Lys Thr Pro Glu Arg Gly Gly Arg 
    50                  55                  60                  


Arg Ser Ala Trp Val Arg Asn Trp Cys Val Trp Thr His Ile Arg Asp 
65                  70                  75                  80  


Tyr Phe Pro Ile Thr Ile Leu Lys Thr Lys Asp Leu Ser Pro Glu His 
                85                  90                  95      


Asn Tyr Leu Met Gly Val His Pro His Gly Leu Leu Thr Phe Gly Ala 
            100                 105                 110         


Phe Cys Asn Phe Cys Thr Glu Ala Thr Gly Phe Ser Lys Thr Phe Pro 
        115                 120                 125             


Gly Ile Thr Pro His Leu Ala Thr Leu Ser Trp Phe Phe Lys Ile Pro 
    130                 135                 140                 


Phe Val Arg Glu Tyr Leu Met Ala Lys Gly Val Cys Ser Val Ser Gln 
145                 150                 155                 160 


Pro Ala Ile Asn Tyr Leu Leu Ser His Gly Thr Gly Asn Leu Val Gly 
                165                 170                 175     


Ile Val Val Gly Gly Val Gly Glu Ala Leu Gln Ser Val Pro Asn Thr 
            180                 185                 190         


Thr Thr Leu Ile Leu Gln Lys Arg Lys Gly Phe Val Arg Thr Ala Leu 
        195                 200                 205             


Gln His Gly Ala His Leu Val Pro Thr Phe Thr Phe Gly Glu Thr Glu 
    210                 215                 220                 


Val Tyr Asp Gln Val Leu Phe His Lys Asp Ser Arg Met Tyr Lys Phe 
225                 230                 235                 240 


Gln Ser Cys Phe Arg Arg Ile Phe Gly Phe Tyr Cys Cys Val Phe Tyr 
                245                 250                 255     


Gly Gln Ser Phe Cys Gln Gly Ser Thr Gly Leu Leu Pro Tyr Ser Arg 
            260                 265                 270         


Pro Ile Val Thr Val Val Gly Glu Pro Leu Pro Leu Pro Gln Ile Glu 
        275                 280                 285             


Lys Pro Ser Gln Glu Met Val Asp Lys Tyr His Ala Leu Tyr Met Asp 
    290                 295                 300                 


Ala Leu His Lys Leu Phe Asp Gln His Lys Thr His Tyr Gly Cys Ser 
305                 310                 315                 320 


Glu Thr Gln Lys Leu Phe Phe Leu 
                325             


<210>  616
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  616

Met Ala Gln Leu Glu Gly Tyr Cys Phe Ser Ala Ala Leu Ser Cys Thr 
1               5                   10                  15      


Phe Leu Val Ser Cys Leu Leu Phe Ser Ala Phe Ser Arg Ala Leu Arg 
            20                  25                  30          


Glu Pro Tyr Met Asp Glu Ile Phe His Leu Pro Gln Ala Gln Arg Tyr 
        35                  40                  45              


Cys Glu Gly His Phe Ser Leu Ser Gln Trp Asp Pro Met Ile Thr Thr 
    50                  55                  60                  


Leu Pro Gly Leu Tyr Leu Val Ser Val Gly Val Val Lys Pro Ala Ile 
65                  70                  75                  80  


Trp Ile Phe Gly Trp Ser Glu His Val Val Cys Ser Ile Gly Met Leu 
                85                  90                  95      


Arg Phe Val Asn Leu Leu Phe Ser Val Gly Asn Phe Tyr Leu Leu Tyr 
            100                 105                 110         


Leu Leu Phe His Lys Val Gln Pro Arg Asn Lys Ala Ala Ser Ser Ile 
        115                 120                 125             


Gln Arg Val Leu Ser Thr Leu Thr Leu Ala Val Phe Pro Thr Leu Tyr 
    130                 135                 140                 


Phe Phe Asn Phe Leu Tyr Tyr Thr Glu Ala Gly Ser Met Phe Phe Thr 
145                 150                 155                 160 


Leu Phe Ala Tyr Leu Met Cys Leu Tyr Gly Asn His Lys Thr Ser Ala 
                165                 170                 175     


Phe Leu Gly Phe Cys Gly Phe Met Phe Arg Gln Thr Asn Ile Ile Trp 
            180                 185                 190         


Ala Val Phe Cys Ala Gly Asn Val Ile Ala Gln Lys Leu Thr Glu Ala 
        195                 200                 205             


Trp Lys Thr Glu Leu Gln Lys Lys Glu Asp Arg Leu Pro Pro Ile Lys 
    210                 215                 220                 


Gly Pro Phe Ala Glu Phe Arg Lys Ile Leu Gln Phe Leu Leu Ala Tyr 
225                 230                 235                 240 


Ser Met Ser Phe Lys Asn Leu Ser Met Leu Phe Cys Leu Thr Trp Pro 
                245                 250                 255     


Tyr Ile Leu Leu Gly Phe Leu Phe Cys Ala Phe Val Val Val Asn Gly 
            260                 265                 270         


Gly Ile Val Ile Gly Asp Arg Ser Ser His Glu Ala Cys Leu His Phe 
        275                 280                 285             


Pro Gln Leu Phe Tyr Phe Phe Ser Phe Thr Leu Phe Phe Ser Phe Pro 
    290                 295                 300                 


His Leu Leu Ser Pro Ser Lys Ile Lys Thr Phe Leu Ser Leu Val Trp 
305                 310                 315                 320 


Lys His Gly Ile Leu Phe Leu Val Val Thr Leu Val Ser Val Phe Leu 
                325                 330                 335     


Val Trp Lys Phe Thr Tyr Ala His Lys Tyr Leu Leu Ala Asp Asn Arg 
            340                 345                 350         


His Tyr Thr Phe Tyr Val Trp Lys Arg Val Phe Gln Arg Tyr Ala Ile 
        355                 360                 365             


Leu Lys Tyr Leu Leu Val Pro Ala Tyr Ile Phe Ala Gly Trp Ser Ile 
    370                 375                 380                 


Ala Asp Ser Leu Lys Ser Lys Pro Ile Phe Trp Asn Leu Met Phe Phe 
385                 390                 395                 400 


Ile Cys Leu Phe Ile Val Ile Val Pro Gln Lys Leu Leu Glu Phe Arg 
                405                 410                 415     


Tyr Phe Ile Leu Pro Tyr Val Ile Tyr Arg Leu Asn Ile Thr Leu Pro 
            420                 425                 430         


Pro Thr Ser Arg Leu Val Cys Glu Leu Ser Cys Tyr Ala Ile Val Asn 
        435                 440                 445             


Phe Ile Thr Phe Tyr Ile Phe Leu Asn Lys Thr Phe Gln Trp Pro Asn 
    450                 455                 460                 


Ser Gln Asp Ile Gln Arg Phe Met Trp 
465                 470             


<210>  617
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  617

Met Trp Thr Leu Lys Ser Ser Leu Val Leu Leu Leu Cys Leu Thr Cys 
1               5                   10                  15      


Ser Tyr Ala Phe Met Phe Ser Ser Leu Arg Gln Lys Thr Ser Glu Pro 
            20                  25                  30          


Gln Gly Lys Val Pro Cys Gly Glu His Phe Arg Ile Arg Gln Asn Leu 
        35                  40                  45              


Pro Glu His Thr Gln Gly Trp Leu Gly Ser Lys Trp Leu Trp Leu Leu 
    50                  55                  60                  


Phe Ala Val Val Pro Phe Val Ile Leu Gln Cys Gln Arg Asp Ser Glu 
65                  70                  75                  80  


Lys Asn Lys Glu Gln Ser Pro Pro Gly Leu Arg Gly Phe Pro Phe Arg 
                85                  90                  95      


Thr Pro Leu Lys Lys Asn Gln Asn Ala Ser Leu Tyr Lys Asp Cys Val 
            100                 105                 110         


Phe Asn Thr Leu Asn Glu Leu Glu Val Glu Leu Leu Lys Phe Val Ser 
        115                 120                 125             


Glu Val Gln Asn Leu Lys Gly Ala Met Ala Thr Gly Ser Gly Ser Asn 
    130                 135                 140                 


Leu Lys Leu Arg Arg Ser Glu Met Pro Ala Asp Pro Tyr His Val Thr 
145                 150                 155                 160 


Ile Cys Lys Ile Trp Gly Glu Glu Ser Ser Ser 
                165                 170     


<210>  618
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  618

Met Ala Gln Ser Asp Phe Leu Tyr Pro Glu Asn Pro Lys Arg Arg Glu 
1               5                   10                  15      


Glu Val Asn Arg Leu His Gln Gln Leu Leu Asp Cys Leu Ser Asp Ser 
            20                  25                  30          


Phe Asp Val Thr Asn Lys Leu Thr Glu Val Leu Asn Met His Leu Gly 
        35                  40                  45              


Cys Arg Leu Ala Ser Ile Glu Met Lys Arg Asp Gly Thr Ile Lys Glu 
    50                  55                  60                  


Asn Cys Asp Leu Ile Ile Gln Ala Ile Met Lys Ile Gln Lys Glu Leu 
65                  70                  75                  80  


Gln Lys Val Asp Glu Ala Leu Lys Asp Lys Leu Glu Pro Thr Leu Tyr 
                85                  90                  95      


Arg Lys Leu Gln Asp Ile Lys Glu Lys Glu Thr Asp Lys Ile Ala Ile 
            100                 105                 110         


Val Gln Lys Val Ile Ser Val Ile Leu Gly Glu Ala Thr Ser Ala Ala 
        115                 120                 125             


Ser Ala Val Ala Val Lys Leu Val Gly Ser Asn Val Thr Thr Gly Ile 
    130                 135                 140                 


Ile Asn Lys Leu Val Thr Val Leu Ala Gln Ile Gly Ala Ser Leu Leu 
145                 150                 155                 160 


Gly Ser Ile Gly Val Ala Val Leu Gly Leu Gly Ile Asp Met Ile Val 
                165                 170                 175     


Arg Ala Ile Leu Gly Ala Val Glu Lys Thr Gln Leu Gln Ala Ala Ile 
            180                 185                 190         


Lys Ser Tyr Glu Lys His Leu Val Glu Phe Lys Ser Ala Ser Glu Lys 
        195                 200                 205             


Tyr Asn His Ala Ile Thr Glu Val Ile Asn Thr Val Lys His Gln Met 
    210                 215                 220                 


Lys 
225 


<210>  619
<211>  846
<212>  PRT
<213>  Homo sapiens

<400>  619

Met Cys Phe Leu Arg Arg Pro Gly Ala Pro Ala Ser Trp Ile Trp Trp 
1               5                   10                  15      


Arg Met Leu Arg Gln Val Leu Arg Arg Gly Leu Gln Ser Phe Cys His 
            20                  25                  30          


Arg Leu Gly Leu Cys Val Ser Arg His Pro Val Phe Phe Leu Thr Val 
        35                  40                  45              


Pro Ala Val Leu Thr Ile Thr Phe Gly Leu Ser Ala Leu Asn Arg Phe 
    50                  55                  60                  


Gln Pro Glu Gly Asp Leu Glu Arg Leu Val Ala Pro Ser His Ser Leu 
65                  70                  75                  80  


Ala Lys Ile Glu Arg Ser Leu Ala Ser Ser Leu Phe Pro Leu Asp Gln 
                85                  90                  95      


Ser Lys Ser Gln Leu Tyr Ser Asp Leu His Thr Pro Gly Arg Tyr Gly 
            100                 105                 110         


Arg Val Ile Leu Leu Ser Pro Thr Gly Asp Asn Ile Leu Leu Gln Ala 
        115                 120                 125             


Glu Gly Ile Leu Gln Thr His Arg Ala Val Leu Glu Met Lys Asp Gly 
    130                 135                 140                 


Arg Asn Ser Phe Ile Gly His Gln Leu Gly Gly Val Val Glu Val Pro 
145                 150                 155                 160 


Asn Ser Lys Asp Gln Arg Val Lys Ser Ala Arg Ala Ile Gln Ile Thr 
                165                 170                 175     


Tyr Tyr Leu Gln Thr Tyr Gly Ser Ala Thr Gln Asp Leu Ile Gly Glu 
            180                 185                 190         


Lys Trp Glu Asn Glu Phe Cys Lys Leu Ile Arg Lys Leu Gln Glu Glu 
        195                 200                 205             


His Gln Glu Leu Gln Leu Tyr Ser Leu Ala Ser Phe Ser Leu Trp Arg 
    210                 215                 220                 


Asp Phe His Lys Thr Ser Ile Leu Ala Arg Ser Lys Val Leu Val Ser 
225                 230                 235                 240 


Leu Val Leu Ile Leu Thr Thr Ala Thr Leu Ser Ser Ser Met Lys Asp 
                245                 250                 255     


Cys Leu Arg Ser Lys Pro Phe Leu Gly Leu Leu Gly Val Leu Thr Val 
            260                 265                 270         


Cys Ile Ser Ile Ile Thr Ala Ala Gly Ile Phe Phe Ile Thr Asp Gly 
        275                 280                 285             


Lys Tyr Asn Ser Thr Leu Leu Gly Ile Pro Phe Phe Ala Met Gly His 
    290                 295                 300                 


Gly Thr Lys Gly Val Phe Glu Leu Leu Ser Gly Trp Arg Arg Thr Lys 
305                 310                 315                 320 


Glu Asn Leu Pro Phe Lys Asp Arg Ile Ala Asp Ala Tyr Ser Asp Val 
                325                 330                 335     


Met Val Thr Tyr Thr Met Thr Ser Ser Leu Tyr Phe Ile Thr Phe Gly 
            340                 345                 350         


Met Gly Ala Ser Pro Phe Thr Asn Ile Glu Ala Val Lys Val Phe Cys 
        355                 360                 365             


Gln Asn Met Cys Val Ser Ile Leu Leu Asn Tyr Phe Tyr Ile Phe Ser 
    370                 375                 380                 


Phe Phe Gly Ser Cys Leu Val Phe Ala Gly Gln Leu Glu Gln Asn Arg 
385                 390                 395                 400 


Tyr His Ser Ile Phe Cys Cys Lys Ile Pro Ser Ala Glu Tyr Leu Asp 
                405                 410                 415     


Arg Lys Pro Val Trp Phe Gln Thr Val Met Ser Asp Gly His Gln Gln 
            420                 425                 430         


Thr Ser His His Glu Thr Asn Pro Tyr Gln His His Phe Ile Gln His 
        435                 440                 445             


Phe Leu Arg Glu His Tyr Asn Glu Trp Ile Thr Asn Ile Tyr Val Lys 
    450                 455                 460                 


Pro Phe Val Val Ile Leu Tyr Leu Ile Tyr Ala Ser Phe Ser Phe Met 
465                 470                 475                 480 


Gly Cys Leu Gln Ile Ser Asp Gly Ala Asn Ile Ile Asn Leu Leu Ala 
                485                 490                 495     


Ser Asp Ser Pro Ser Val Ser Tyr Ala Met Val Gln Gln Lys Tyr Phe 
            500                 505                 510         


Ser Asn Tyr Ser Pro Val Ile Gly Phe Tyr Val Tyr Glu Pro Leu Glu 
        515                 520                 525             


Tyr Trp Asn Ser Ser Val Gln Asp Asp Leu Arg Arg Leu Cys Ser Gly 
    530                 535                 540                 


Phe Thr Ala Val Ser Trp Val Glu Gln Tyr Tyr Gln Phe Leu Lys Val 
545                 550                 555                 560 


Ser Asn Val Ser Ala Asn Asn Lys Ser Asp Phe Ile Ser Val Leu Gln 
                565                 570                 575     


Ser Ser Phe Leu Lys Lys Pro Glu Phe Gln His Phe Arg Asn Asp Ile 
            580                 585                 590         


Ile Phe Ser Lys Ala Gly Asp Glu Ser Asn Ile Ile Ala Ser Arg Leu 
        595                 600                 605             


Tyr Leu Val Ala Arg Thr Ser Arg Asp Lys Gln Lys Glu Ile Thr Glu 
    610                 615                 620                 


Val Leu Glu Lys Leu Arg Pro Leu Ser Leu Ser Lys Ser Ile Arg Phe 
625                 630                 635                 640 


Ile Val Phe Asn Pro Ser Phe Val Phe Met Asp His Tyr Ser Leu Ser 
                645                 650                 655     


Val Thr Val Pro Val Leu Ile Ala Gly Phe Gly Val Leu Leu Val Leu 
            660                 665                 670         


Ile Leu Thr Phe Phe Leu Val Ile His Pro Leu Gly Asn Phe Trp Leu 
        675                 680                 685             


Ile Leu Ser Val Thr Ser Ile Glu Leu Gly Val Leu Gly Leu Met Thr 
    690                 695                 700                 


Leu Trp Asn Val Asp Met Asp Cys Ile Ser Ile Leu Cys Leu Ile Tyr 
705                 710                 715                 720 


Thr Leu Asn Phe Ala Ile Asp His Cys Ala Pro Leu Leu Phe Thr Phe 
                725                 730                 735     


Val Leu Ala Thr Glu His Thr Arg Thr Gln Cys Ile Lys Ser Ser Leu 
            740                 745                 750         


Gln Asp His Gly Thr Ala Ile Leu Gln Asn Val Thr Ser Phe Leu Ile 
        755                 760                 765             


Gly Leu Val Pro Leu Leu Phe Val Pro Ser Asn Leu Thr Phe Thr Leu 
    770                 775                 780                 


Phe Lys Cys Leu Leu Leu Thr Gly Gly Cys Thr Leu Leu His Cys Phe 
785                 790                 795                 800 


Val Ile Leu Pro Val Phe Leu Thr Phe Phe Pro Pro Ser Lys Lys His 
                805                 810                 815     


His Lys Lys Lys Lys Arg Ala Lys Arg Lys Glu Arg Glu Glu Ile Glu 
            820                 825                 830         


Cys Ile Glu Ile Gln Glu Asn Pro Asp His Val Thr Thr Val 
        835                 840                 845     


<210>  620
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  620

Met Val His Val Ser Asn Arg Ser Ile Gln Gly Met Asn Ile Leu Phe 
1               5                   10                  15      


Ser Ser Trp Ala Val Val Leu Met Val Met Gly Ile Thr Leu Asp Lys 
            20                  25                  30          


Trp Val Glu Leu Ile Ser Glu Asp Glu Arg Ala Lys Met Asn His Ser 
        35                  40                  45              


Pro Trp Met Met Cys Cys Pro Ala Leu Trp Pro Glu Asp Asp Leu Lys 
    50                  55                  60                  


Val Val Arg Ile Met Met Thr Ser Ser Leu Gly Leu Ser Phe Leu Leu 
65                  70                  75                  80  


Asn Leu Ile Leu Gly Met Lys Phe Thr Tyr Leu Ile Pro Gln Asn Lys 
                85                  90                  95      


Tyr Ile Gln Leu Phe Thr Thr Ile Leu Ser Phe Phe Ser Gly Ile Ser 
            100                 105                 110         


Leu Leu Trp Ala Leu Ile Leu Tyr His Asn Lys Leu Lys Gln Gly Gln 
        115                 120                 125             


Ser Met His Phe Ser Ser Tyr Arg Ile Thr Trp Ile Met Tyr Thr Ala 
    130                 135                 140                 


Tyr Leu Asn Val Phe Phe Leu Ser Val Cys Gly Val Leu Ser Leu Leu 
145                 150                 155                 160 


Glu Cys Lys Leu Ser Thr Ser Ser Cys Thr Cys Leu Asn Ile His Lys 
                165                 170                 175     


Ser Asp Asn Glu Cys Lys Glu Ser Glu Asn Ser Ile Glu Asp Ile Ser 
            180                 185                 190         


Leu Pro Glu Cys Thr Ala Met Pro Arg Ser Ile Val Arg Ala His Thr 
        195                 200                 205             


Val Asn Ser Leu Asn Lys Lys Val Gln Thr Arg His Val Thr Trp Ala 
    210                 215                 220                 


Leu 
225 


<210>  621
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  621

Met Ile Gly Ser Gly Leu Ala Gly Ser Gly Gly Ala Gly Gly Pro Ser 
1               5                   10                  15      


Ser Thr Val Thr Trp Cys Ala Leu Phe Ser Asn His Val Ala Ala Thr 
            20                  25                  30          


Gln Ala Ser Leu Leu Leu Ser Phe Val Trp Met Pro Ala Leu Leu Pro 
        35                  40                  45              


Val Ala Ser Arg Leu Leu Leu Leu Pro Arg Val Leu Leu Thr Met Ala 
    50                  55                  60                  


Ser Gly Ser Pro Pro Thr Gln Pro Ser Pro Ala Ser Asp Ser Gly Ser 
65                  70                  75                  80  


Gly Tyr Val Pro Gly Ser Val Ser Ala Ala Phe Val Thr Cys Pro Asn 
                85                  90                  95      


Glu Lys Val Ala Lys Glu Ile Ala Arg Ala Val Val Glu Lys Arg Leu 
            100                 105                 110         


Ala Ala Cys Val Asn Leu Ile Pro Gln Ile Thr Ser Ile Tyr Glu Trp 
        115                 120                 125             


Lys Gly Lys Ile Glu Glu Asp Ser Glu Val Leu Met Met Ile Lys Thr 
    130                 135                 140                 


Gln Ser Ser Leu Val Pro Ala Leu Thr Asp Phe Val Arg Ser Val His 
145                 150                 155                 160 


Pro Tyr Glu Val Ala Glu Val Ile Ala Leu Pro Val Glu Gln Gly Asn 
                165                 170                 175     


Phe Pro Tyr Leu Gln Trp Val Arg Gln Val Thr Glu Ser Val Ser Asp 
            180                 185                 190         


Ser Ile Thr Val Leu Pro 
        195             


<210>  622
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  622

Met Ala Ala Val Val Ala Lys Arg Glu Gly Pro Pro Phe Ile Ser Glu 
1               5                   10                  15      


Ala Ala Val Arg Gly Asn Ala Ala Val Leu Asp Tyr Cys Arg Thr Ser 
            20                  25                  30          


Val Ser Ala Leu Ser Gly Ala Thr Ala Gly Ile Leu Gly Leu Thr Gly 
        35                  40                  45              


Leu Tyr Gly Phe Ile Phe Tyr Leu Leu Ala Ser Val Leu Leu Ser Leu 
    50                  55                  60                  


Leu Leu Ile Leu Lys Ala Gly Arg Arg Trp Asn Lys Tyr Phe Lys Ser 
65                  70                  75                  80  


Arg Arg Pro Leu Phe Thr Gly Gly Leu Ile Gly Gly Leu Phe Thr Tyr 
                85                  90                  95      


Val Leu Phe Trp Thr Phe Leu Tyr Gly Met Val His Val Tyr 
            100                 105                 110 


<210>  623
<211>  855
<212>  PRT
<213>  Homo sapiens

<400>  623

Met Ile Leu Ile Pro Arg Met Leu Leu Val Leu Phe Leu Leu Leu Pro 
1               5                   10                  15      


Ile Leu Ser Ser Ala Lys Ala Gln Val Asn Pro Ala Ile Cys Arg Tyr 
            20                  25                  30          


Pro Leu Gly Met Ser Gly Gly Gln Ile Pro Asp Glu Asp Ile Thr Ala 
        35                  40                  45              


Ser Ser Gln Trp Ser Glu Ser Thr Ala Ala Lys Tyr Gly Arg Leu Asp 
    50                  55                  60                  


Ser Glu Glu Gly Asp Gly Ala Trp Cys Pro Glu Ile Pro Val Glu Pro 
65                  70                  75                  80  


Asp Asp Leu Lys Glu Phe Leu Gln Ile Asp Leu His Thr Leu His Phe 
                85                  90                  95      


Ile Thr Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly His Gly Ile 
            100                 105                 110         


Glu Phe Ala Pro Met Tyr Lys Ile Asn Tyr Ser Arg Asp Gly Thr Arg 
        115                 120                 125             


Trp Ile Ser Trp Arg Asn Arg His Gly Lys Gln Val Leu Asp Gly Asn 
    130                 135                 140                 


Ser Asn Pro Tyr Asp Ile Phe Leu Lys Asp Leu Glu Pro Pro Ile Val 
145                 150                 155                 160 


Ala Arg Phe Val Arg Phe Ile Pro Val Thr Asp His Ser Met Asn Val 
                165                 170                 175     


Cys Met Arg Val Glu Leu Tyr Gly Cys Val Trp Leu Asp Gly Leu Val 
            180                 185                 190         


Ser Tyr Asn Ala Pro Ala Gly Gln Gln Phe Val Leu Pro Gly Gly Ser 
        195                 200                 205             


Ile Ile Tyr Leu Asn Asp Ser Val Tyr Asp Gly Ala Val Gly Tyr Ser 
    210                 215                 220                 


Met Thr Glu Gly Leu Gly Gln Leu Thr Asp Gly Val Ser Gly Leu Asp 
225                 230                 235                 240 


Asp Phe Thr Gln Thr His Glu Tyr His Val Trp Pro Gly Tyr Asp Tyr 
                245                 250                 255     


Val Gly Trp Arg Asn Glu Ser Ala Thr Asn Gly Tyr Ile Glu Ile Met 
            260                 265                 270         


Phe Glu Phe Asp Arg Ile Arg Asn Phe Thr Thr Met Lys Val His Cys 
        275                 280                 285             


Asn Asn Met Phe Ala Lys Gly Val Lys Ile Phe Lys Glu Val Gln Cys 
    290                 295                 300                 


Tyr Phe Arg Ser Glu Ala Ser Glu Trp Glu Pro Asn Ala Ile Ser Phe 
305                 310                 315                 320 


Pro Leu Val Leu Asp Asp Val Asn Pro Ser Ala Arg Phe Val Thr Val 
                325                 330                 335     


Pro Leu His His Arg Met Ala Ser Ala Ile Lys Cys Gln Tyr His Phe 
            340                 345                 350         


Ala Asp Thr Trp Met Met Phe Ser Glu Ile Thr Phe Gln Ser Asp Ala 
        355                 360                 365             


Ala Met Tyr Asn Asn Ser Glu Ala Leu Pro Thr Ser Pro Met Ala Pro 
    370                 375                 380                 


Thr Thr Tyr Asp Pro Met Leu Lys Val Asp Asp Ser Asn Thr Arg Ile 
385                 390                 395                 400 


Leu Ile Gly Cys Leu Val Ala Ile Ile Phe Ile Leu Leu Ala Ile Ile 
                405                 410                 415     


Val Ile Ile Leu Trp Arg Gln Phe Trp Gln Lys Met Leu Glu Lys Ala 
            420                 425                 430         


Ser Arg Arg Met Leu Asp Asp Glu Met Thr Val Ser Leu Ser Leu Pro 
        435                 440                 445             


Ser Asp Ser Ser Met Phe Asn Asn Asn Arg Ser Ser Ser Pro Ser Glu 
    450                 455                 460                 


Gln Gly Ser Asn Ser Thr Tyr Asp Arg Ile Phe Pro Leu Arg Pro Asp 
465                 470                 475                 480 


Tyr Gln Glu Pro Ser Arg Leu Ile Arg Lys Leu Pro Glu Phe Ala Pro 
                485                 490                 495     


Gly Glu Glu Glu Ser Gly Cys Ser Gly Val Val Lys Pro Val Gln Pro 
            500                 505                 510         


Ser Gly Pro Glu Gly Val Pro His Tyr Ala Glu Ala Asp Ile Val Asn 
        515                 520                 525             


Leu Gln Gly Val Thr Gly Gly Asn Thr Tyr Ser Val Pro Ala Val Thr 
    530                 535                 540                 


Met Asp Leu Leu Ser Gly Lys Asp Val Ala Val Glu Glu Phe Pro Arg 
545                 550                 555                 560 


Lys Leu Leu Thr Phe Lys Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu 
                565                 570                 575     


Val His Leu Cys Glu Val Glu Gly Met Glu Lys Phe Lys Asp Lys Asp 
            580                 585                 590         


Phe Ala Leu Asp Val Ser Ala Asn Gln Pro Val Leu Val Ala Val Lys 
        595                 600                 605             


Met Leu Arg Ala Asp Ala Asn Lys Asn Ala Arg Asn Asp Phe Leu Lys 
    610                 615                 620                 


Glu Ile Lys Ile Met Ser Arg Leu Lys Asp Pro Asn Ile Ile His Leu 
625                 630                 635                 640 


Leu Ala Val Cys Ile Thr Asp Asp Pro Leu Cys Met Ile Thr Glu Tyr 
                645                 650                 655     


Met Glu Asn Gly Asp Leu Asn Gln Phe Leu Ser Arg His Glu Pro Pro 
            660                 665                 670         


Asn Ser Ser Ser Ser Asp Val Arg Thr Val Ser Tyr Thr Asn Leu Lys 
        675                 680                 685             


Phe Met Ala Thr Gln Ile Ala Ser Gly Met Lys Tyr Leu Ser Ser Leu 
    690                 695                 700                 


Asn Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Lys 
705                 710                 715                 720 


Asn Tyr Thr Ile Lys Ile Ala Asp Phe Gly Met Ser Arg Asn Leu Tyr 
                725                 730                 735     


Ser Gly Asp Tyr Tyr Arg Ile Gln Gly Arg Ala Val Leu Pro Ile Arg 
            740                 745                 750         


Trp Met Ser Trp Glu Ser Ile Leu Leu Gly Lys Phe Thr Thr Ala Ser 
        755                 760                 765             


Asp Val Trp Ala Phe Gly Val Thr Leu Trp Glu Thr Phe Thr Phe Cys 
    770                 775                 780                 


Gln Glu Gln Pro Tyr Ser Gln Leu Ser Asp Glu Gln Val Ile Glu Asn 
785                 790                 795                 800 


Thr Gly Glu Phe Phe Arg Asp Gln Gly Arg Gln Thr Tyr Leu Pro Gln 
                805                 810                 815     


Pro Ala Ile Cys Pro Asp Ser Val Tyr Lys Leu Met Leu Ser Cys Trp 
            820                 825                 830         


Arg Arg Asp Thr Lys Asn Arg Pro Ser Phe Gln Glu Ile His Leu Leu 
        835                 840                 845             


Leu Leu Gln Gln Gly Asp Glu 
    850                 855 


<210>  624
<211>  1182
<212>  PRT
<213>  Homo sapiens

<400>  624

Met Ala Asn Gly Gly Gly Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Ser Ser Leu Arg Met Ser Ser Asn Ile His Ala Asn 
            20                  25                  30          


His Leu Ser Leu Asp Ala Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
        35                  40                  45              


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Val His Glu Pro 
    50                  55                  60                  


Lys Met Asp Ala Leu Ile Ile Pro Val Thr Met Glu Val Pro Cys Asp 
65                  70                  75                  80  


Ser Arg Gly Gln Arg Met Trp Trp Ala Phe Leu Ala Ser Ser Met Val 
                85                  90                  95      


Thr Phe Phe Gly Gly Leu Phe Ile Ile Leu Leu Trp Arg Thr Leu Lys 
            100                 105                 110         


Tyr Leu Trp Thr Val Cys Cys His Cys Gly Gly Lys Thr Lys Glu Ala 
        115                 120                 125             


Gln Lys Ile Asn Asn Gly Ser Ser Gln Ala Asp Gly Thr Leu Lys Pro 
    130                 135                 140                 


Val Asp Glu Lys Glu Glu Ala Val Ala Ala Glu Val Gly Trp Met Thr 
145                 150                 155                 160 


Ser Val Lys Asp Trp Ala Gly Val Met Ile Ser Ala Gln Thr Leu Thr 
                165                 170                 175     


Gly Arg Val Leu Val Val Leu Val Phe Ala Leu Ser Ile Gly Ala Leu 
            180                 185                 190         


Val Ile Tyr Phe Ile Asp Ser Ser Asn Pro Ile Glu Ser Cys Gln Asn 
        195                 200                 205             


Phe Tyr Lys Asp Phe Thr Leu Gln Ile Asp Met Ala Phe Asn Val Phe 
    210                 215                 220                 


Phe Leu Leu Tyr Phe Gly Leu Arg Phe Ile Ala Ala Asn Asp Lys Leu 
225                 230                 235                 240 


Trp Phe Trp Leu Glu Val Asn Ser Val Val Asp Phe Phe Thr Val Pro 
                245                 250                 255     


Pro Val Phe Val Ser Val Tyr Leu Asn Arg Ser Trp Leu Gly Leu Arg 
            260                 265                 270         


Phe Leu Arg Ala Leu Arg Leu Ile Gln Phe Ser Glu Ile Leu Gln Phe 
        275                 280                 285             


Leu Asn Ile Leu Lys Thr Ser Asn Ser Ile Lys Leu Val Asn Leu Leu 
    290                 295                 300                 


Ser Ile Phe Ile Ser Thr Trp Leu Thr Ala Ala Gly Phe Ile His Leu 
305                 310                 315                 320 


Val Glu Asn Ser Gly Asp Pro Trp Glu Asn Phe Gln Asn Asn Gln Ala 
                325                 330                 335     


Leu Thr Tyr Trp Glu Cys Val Tyr Leu Leu Met Val Thr Met Ser Thr 
            340                 345                 350         


Val Gly Tyr Gly Asp Val Tyr Ala Lys Thr Thr Leu Gly Arg Leu Phe 
        355                 360                 365             


Met Val Phe Phe Ile Leu Gly Gly Leu Ala Met Phe Ala Ser Tyr Val 
    370                 375                 380                 


Pro Glu Ile Ile Glu Leu Ile Gly Asn Arg Lys Lys Tyr Gly Gly Ser 
385                 390                 395                 400 


Tyr Ser Ala Val Ser Gly Arg Lys His Ile Val Val Cys Gly His Ile 
                405                 410                 415     


Thr Leu Glu Ser Val Ser Asn Phe Leu Lys Asp Phe Leu His Lys Asp 
            420                 425                 430         


Arg Asp Asp Val Asn Val Glu Ile Val Phe Leu His Asn Ile Ser Pro 
        435                 440                 445             


Asn Leu Glu Leu Glu Ala Leu Phe Lys Arg His Phe Thr Gln Val Glu 
    450                 455                 460                 


Phe Tyr Gln Gly Ser Val Leu Asn Pro His Asp Leu Ala Arg Val Lys 
465                 470                 475                 480 


Ile Glu Ser Ala Asp Ala Cys Leu Ile Leu Ala Asn Lys Tyr Cys Ala 
                485                 490                 495     


Asp Pro Asp Ala Glu Asp Ala Ser Asn Ile Met Arg Val Ile Ser Ile 
            500                 505                 510         


Lys Asn Tyr His Pro Lys Ile Arg Ile Ile Thr Gln Met Leu Gln Tyr 
        515                 520                 525             


His Asn Lys Ala His Leu Leu Asn Ile Pro Ser Trp Asn Trp Lys Glu 
    530                 535                 540                 


Gly Asp Asp Ala Ile Cys Leu Ala Glu Leu Lys Leu Gly Phe Ile Ala 
545                 550                 555                 560 


Gln Ser Cys Leu Ala Gln Gly Leu Ser Thr Met Leu Ala Asn Leu Phe 
                565                 570                 575     


Ser Met Arg Ser Phe Ile Lys Ile Glu Glu Asp Thr Trp Gln Lys Tyr 
            580                 585                 590         


Tyr Leu Glu Gly Val Ser Asn Glu Met Tyr Thr Glu Tyr Leu Ser Ser 
        595                 600                 605             


Ala Phe Val Gly Leu Ser Phe Pro Thr Val Cys Glu Leu Cys Phe Val 
    610                 615                 620                 


Lys Leu Lys Leu Leu Met Ile Ala Ile Glu Tyr Lys Ser Ala Asn Arg 
625                 630                 635                 640 


Glu Ser Arg Ser Arg Lys Arg Ile Leu Ile Asn Pro Gly Asn His Leu 
                645                 650                 655     


Lys Ile Gln Glu Gly Thr Leu Gly Phe Phe Ile Ala Ser Asp Ala Lys 
            660                 665                 670         


Glu Val Lys Arg Ala Phe Phe Tyr Cys Lys Ala Cys His Asp Asp Ile 
        675                 680                 685             


Thr Asp Pro Lys Arg Ile Lys Lys Cys Gly Cys Lys Arg Leu Glu Asp 
    690                 695                 700                 


Glu Gln Pro Ser Thr Leu Ser Pro Lys Lys Lys Gln Arg Asn Gly Gly 
705                 710                 715                 720 


Met Arg Asn Ser Pro Asn Thr Ser Pro Lys Leu Met Arg His Asp Pro 
                725                 730                 735     


Leu Leu Ile Pro Gly Asn Asp Gln Ile Asp Asn Met Asp Ser Asn Val 
            740                 745                 750         


Lys Lys Tyr Asp Ser Thr Gly Met Phe His Trp Cys Ala Pro Lys Glu 
        755                 760                 765             


Ile Glu Lys Val Ile Leu Thr Arg Ser Glu Ala Ala Met Thr Val Leu 
    770                 775                 780                 


Ser Gly His Val Val Val Cys Ile Phe Gly Asp Val Ser Ser Ala Leu 
785                 790                 795                 800 


Ile Gly Leu Arg Asn Leu Val Met Pro Leu Arg Ala Ser Asn Phe His 
                805                 810                 815     


Tyr His Glu Leu Lys His Ile Val Phe Val Gly Ser Ile Glu Tyr Leu 
            820                 825                 830         


Lys Arg Glu Trp Glu Thr Leu His Asn Phe Pro Lys Val Ser Ile Leu 
        835                 840                 845             


Pro Gly Thr Pro Leu Ser Arg Ala Asp Leu Arg Ala Val Asn Ile Asn 
    850                 855                 860                 


Leu Cys Asp Met Cys Val Ile Leu Ser Ala Asn Gln Asn Asn Ile Asp 
865                 870                 875                 880 


Asp Thr Ser Leu Gln Asp Lys Glu Cys Ile Leu Ala Ser Leu Asn Ile 
                885                 890                 895     


Lys Ser Met Gln Phe Asp Asp Ser Ile Gly Val Leu Gln Ala Asn Ser 
            900                 905                 910         


Gln Gly Phe Thr Pro Pro Gly Met Asp Arg Ser Ser Pro Asp Asn Ser 
        915                 920                 925             


Pro Val His Gly Met Leu Arg Gln Pro Ser Ile Thr Thr Gly Val Asn 
    930                 935                 940                 


Ile Pro Ile Ile Thr Glu Leu Val Asn Asp Thr Asn Val Gln Phe Leu 
945                 950                 955                 960 


Asp Gln Asp Asp Asp Asp Asp Pro Asp Thr Glu Leu Tyr Leu Thr Gln 
                965                 970                 975     


Pro Phe Ala Cys Gly Thr Ala Phe Ala Val Ser Val Leu Asp Ser Leu 
            980                 985                 990         


Met Ser Ala Thr Tyr Phe Asn Asp  Asn Ile Leu Thr Leu  Ile Arg Thr 
        995                 1000                 1005             


Leu Val  Thr Gly Gly Ala Thr  Pro Glu Leu Glu Ala  Leu Ile Ala 
    1010                 1015                 1020             


Glu Glu  Asn Ala Leu Arg Gly  Gly Tyr Ser Thr Pro  Gln Thr Leu 
    1025                 1030                 1035             


Ala Asn  Arg Asp Arg Cys Arg  Val Ala Gln Leu Ala  Leu Leu Asp 
    1040                 1045                 1050             


Gly Pro  Phe Ala Asp Leu Gly  Asp Gly Gly Cys Tyr  Gly Asp Leu 
    1055                 1060                 1065             


Phe Cys  Lys Ala Leu Lys Thr  Tyr Asn Met Leu Cys  Phe Gly Ile 
    1070                 1075                 1080             


Tyr Arg  Leu Arg Asp Ala His  Leu Ser Thr Pro Ser  Gln Cys Thr 
    1085                 1090                 1095             


Lys Arg  Tyr Val Ile Thr Asn  Pro Pro Tyr Glu Phe  Glu Leu Val 
    1100                 1105                 1110             


Pro Thr  Asp Leu Ile Phe Cys  Leu Met Gln Phe Asp  His Asn Ala 
    1115                 1120                 1125             


Gly Gln  Ser Arg Ala Ser Leu  Ser His Ser Ser His  Ser Ser Gln 
    1130                 1135                 1140             


Ser Ser  Ser Lys Lys Ser Ser  Ser Val His Ser Ile  Pro Ser Thr 
    1145                 1150                 1155             


Ala Asn  Arg Gln Asn Arg Pro  Lys Ser Arg Glu Ser  Arg Asp Lys 
    1160                 1165                 1170             


Gln Asn  Arg Lys Glu Met Val  Tyr Arg 
    1175                 1180         


<210>  625
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  625

Met Pro Ala Leu Leu Pro Val Ala Ser Arg Leu Leu Leu Leu Pro Arg 
1               5                   10                  15      


Val Leu Leu Thr Met Ala Ser Gly Ser Pro Pro Thr Gln Pro Ser Pro 
            20                  25                  30          


Ala Ser Asp Ser Gly Ser Gly Tyr Val Pro Gly Ser Val Ser Ala Ala 
        35                  40                  45              


Phe Val Thr Cys Pro Asn Glu Lys Val Ala Lys Glu Ile Ala Arg Ala 
    50                  55                  60                  


Val Val Glu Lys Arg Leu Ala Ala Cys Val Asn Leu Ile Pro Gln Ile 
65                  70                  75                  80  


Thr Ser Ile Tyr Glu Trp Lys Gly Lys Ile Glu Glu Asp Ser Glu Val 
                85                  90                  95      


Leu Met Met Ile Lys Thr Gln Ser Ser Leu Val Pro Ala Leu Thr Asp 
            100                 105                 110         


Phe Val Arg Ser Val His Pro Tyr Glu Val Ala Glu Val Ile Ala Leu 
        115                 120                 125             


Pro Val Glu Gln Gly Asn Phe Pro Tyr Leu Gln Trp Val Arg Gln Val 
    130                 135                 140                 


Thr Glu Ser Val Ser Asp Ser Ile Thr Val Leu Pro 
145                 150                 155     


<210>  626
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  626

Met Pro Ala Leu Leu Pro Val Ala Ser Arg Leu Leu Leu Leu Pro Arg 
1               5                   10                  15      


Val Leu Leu Thr Met Ala Ser Gly Ser Pro Pro Thr Gln Pro Ser Pro 
            20                  25                  30          


Ala Ser Asp Ser Gly Ser Gly Tyr Val Pro Gly Ser Val Ser Ala Ala 
        35                  40                  45              


Phe Val Thr Cys Pro Asn Glu Lys Val Ala Lys Glu Ile Ala Arg Ala 
    50                  55                  60                  


Val Val Glu Lys Arg Leu Ala Ala Cys Val Asn Leu Ile Pro Gln Ile 
65                  70                  75                  80  


Thr Ser Ile Tyr Glu Trp Lys Gly Lys Ile Glu Glu Asp Ser Glu Val 
                85                  90                  95      


Leu Met Met Ile Lys Thr Gln Ser Ser Leu Val Pro Ala Leu Thr Asp 
            100                 105                 110         


Phe Val Arg Ser Val His Pro Tyr Glu Val Ala Glu Val Ile Ala Leu 
        115                 120                 125             


Pro Val Glu Gln Gly Asn Phe Pro Tyr Leu Gln Trp Val Arg Gln Val 
    130                 135                 140                 


Thr Glu Ser Val Ser Asp Ser Ile Thr Val Leu Pro 
145                 150                 155     


<210>  627
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  627

Met Ser Gly Gly Arg Ala Pro Ala Val Leu Leu Gly Gly Val Ala Ser 
1               5                   10                  15      


Leu Leu Leu Ser Phe Val Trp Met Pro Ala Leu Leu Pro Val Ala Ser 
            20                  25                  30          


Arg Leu Leu Leu Leu Pro Arg Val Leu Leu Thr Met Ala Ser Gly Ser 
        35                  40                  45              


Pro Pro Thr Gln Pro Ser Pro Ala Ser Asp Ser Gly Ser Gly Tyr Val 
    50                  55                  60                  


Pro Gly Ser Val Ser Ala Ala Phe Val Thr Cys Pro Asn Glu Lys Val 
65                  70                  75                  80  


Ala Lys Glu Ile Ala Arg Ala Val Val Glu Lys Arg Leu Ala Ala Cys 
                85                  90                  95      


Val Asn Leu Ile Pro Gln Ile Thr Ser Ile Tyr Glu Trp Lys Gly Lys 
            100                 105                 110         


Ile Glu Glu Asp Ser Glu Val Leu Met Met Ile Lys Thr Gln Ser Ser 
        115                 120                 125             


Leu Val Pro Ala Leu Thr Asp Phe Val Arg Ser Val His Pro Tyr Glu 
    130                 135                 140                 


Val Ala Glu Val Ile Ala Leu Pro Val Glu Gln Gly Asn Phe Pro Tyr 
145                 150                 155                 160 


Leu Gln Trp Val Arg Gln Val Thr Glu Ser Val Ser Asp Ser Ile Thr 
                165                 170                 175     


Val Leu Pro 
            


<210>  628
<211>  489
<212>  PRT
<213>  Homo sapiens

<400>  628

Met Thr Val Val Gly Asn Pro Arg Ser Trp Ser Cys Gln Trp Leu Pro 
1               5                   10                  15      


Ile Leu Ile Leu Leu Leu Gly Thr Gly His Gly Pro Gly Val Glu Gly 
            20                  25                  30          


Val Thr His Tyr Lys Ala Gly Asp Pro Val Ile Leu Tyr Val Asn Lys 
        35                  40                  45              


Val Gly Pro Tyr His Asn Pro Gln Glu Thr Tyr His Tyr Tyr Gln Leu 
    50                  55                  60                  


Pro Val Cys Cys Pro Glu Lys Ile Arg His Lys Ser Leu Ser Leu Gly 
65                  70                  75                  80  


Glu Val Leu Asp Gly Asp Arg Met Ala Glu Ser Leu Tyr Glu Ile Arg 
                85                  90                  95      


Phe Arg Glu Asn Val Glu Lys Arg Ile Leu Cys His Met Gln Leu Ser 
            100                 105                 110         


Ser Ala Gln Val Glu Gln Leu Arg Gln Ala Ile Glu Glu Leu Tyr Tyr 
        115                 120                 125             


Phe Glu Phe Val Val Asp Asp Leu Pro Ile Arg Gly Phe Val Gly Tyr 
    130                 135                 140                 


Met Glu Glu Ser Gly Phe Leu Pro His Ser His Lys Ile Gly Leu Trp 
145                 150                 155                 160 


Thr His Leu Asp Phe His Leu Glu Phe His Gly Asp Arg Ile Ile Phe 
                165                 170                 175     


Ala Asn Val Ser Val Arg Asp Val Lys Pro His Ser Leu Asp Gly Leu 
            180                 185                 190         


Arg Pro Asp Glu Phe Leu Gly Leu Thr His Thr Tyr Ser Val Arg Trp 
        195                 200                 205             


Ser Glu Thr Ser Val Glu Arg Arg Ser Asp Arg Arg Arg Gly Asp Asp 
    210                 215                 220                 


Gly Gly Phe Phe Pro Arg Thr Leu Glu Ile His Trp Leu Ser Ile Ile 
225                 230                 235                 240 


Asn Ser Met Val Leu Val Phe Leu Leu Val Gly Phe Val Ala Val Ile 
                245                 250                 255     


Leu Met Arg Val Leu Arg Asn Asp Leu Ala Arg Tyr Asn Leu Asp Glu 
            260                 265                 270         


Glu Thr Thr Ser Ala Gly Ser Gly Asp Asp Phe Asp Gln Gly Asp Asn 
        275                 280                 285             


Gly Trp Lys Ile Ile His Thr Asp Val Phe Arg Phe Pro Pro Tyr Arg 
    290                 295                 300                 


Gly Leu Leu Cys Ala Val Leu Gly Val Gly Ala Gln Phe Leu Ala Leu 
305                 310                 315                 320 


Gly Thr Gly Ile Ile Val Met Ala Leu Leu Gly Met Phe Asn Val His 
                325                 330                 335     


Arg His Gly Ala Ile Asn Ser Ala Ala Ile Leu Leu Tyr Ala Leu Thr 
            340                 345                 350         


Cys Cys Ile Ser Gly Tyr Val Ser Ser His Phe Tyr Arg Gln Ile Gly 
        355                 360                 365             


Gly Glu Arg Trp Val Trp Asn Ile Ile Leu Thr Thr Ser Leu Phe Ser 
    370                 375                 380                 


Val Pro Phe Phe Leu Thr Trp Ser Val Val Asn Ser Val His Trp Ala 
385                 390                 395                 400 


Asn Gly Ser Thr Gln Ala Leu Pro Ala Thr Thr Ile Leu Leu Leu Leu 
                405                 410                 415     


Thr Val Trp Leu Leu Val Gly Phe Pro Leu Thr Val Ile Gly Gly Ile 
            420                 425                 430         


Phe Gly Lys Asn Asn Ala Ser Pro Phe Asp Ala Pro Cys Arg Thr Lys 
        435                 440                 445             


Asn Ile Ala Arg Glu Ile Pro Pro Gln Pro Trp Tyr Lys Ser Thr Val 
    450                 455                 460                 


Ile His Met Thr Val Gly Gly Phe Leu Pro Phe Arg Tyr Pro Pro Phe 
465                 470                 475                 480 


Ile Pro Trp Leu Leu Leu Ser Gly Ser 
                485                 


<210>  629
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  629

Met Arg Arg Trp Ala Trp Ala Ala Val Val Val Leu Leu Gly Pro Gln 
1               5                   10                  15      


Leu Val Leu Leu Gly Gly Val Gly Ala Arg Arg Glu Ala Gln Arg Thr 
            20                  25                  30          


Gln Gln Pro Gly Gln Arg Ala Asp Pro Pro Asn Ala Thr Ala Ser Ala 
        35                  40                  45              


Ser Ser Arg Glu Gly Leu Pro Glu Ala Pro Lys Pro Ser Gln Ala Ser 
    50                  55                  60                  


Gly Pro Glu Phe Ser Asp Ala His Met Thr Trp Leu Asn Phe Val Arg 
65                  70                  75                  80  


Arg Pro Asp Asp Gly Ala Leu Arg Lys Arg Cys Gly Ser Arg Asp Lys 
                85                  90                  95      


Lys Pro Arg Asp Leu Phe Gly Pro Pro Gly Pro Pro Gly Ala Glu Val 
            100                 105                 110         


Thr Ala Glu Thr Leu Leu His Glu Phe Gln Glu Leu Leu Lys Glu Ala 
        115                 120                 125             


Thr Glu Arg Arg Phe Ser Gly Leu Leu Asp Pro Leu Leu Pro Gln Gly 
    130                 135                 140                 


Ala Gly Leu Arg Leu Val Gly Glu Ala Phe His Cys Arg Leu Gln Gly 
145                 150                 155                 160 


Pro Arg Arg Val Asp Lys Arg Thr Leu Val Glu Leu His Gly Phe Gln 
                165                 170                 175     


Ala Pro Ala Ala Gln Gly Ala Phe Leu Arg Gly Ser Gly Leu Ser Leu 
            180                 185                 190         


Ala Ser Gly Arg Phe Thr Ala Pro Val Ser Gly Ile Phe Gln Phe Ser 
        195                 200                 205             


Ala Ser Leu His Val Asp His Ser Glu Leu Gln Gly Lys Ala Arg Leu 
    210                 215                 220                 


Arg Ala Arg Asp Val Val Cys Val Leu Ile Cys Ile Glu Ser Leu Cys 
225                 230                 235                 240 


Gln Arg His Thr Cys Leu Glu Ala Val Ser Gly Leu Glu Ser Asn Ser 
                245                 250                 255     


Arg Val Phe Thr Leu Gln Val Gln Gly Leu Leu Gln Leu Gln Ala Gly 
            260                 265                 270         


Gln Tyr Ala Ser Val Phe Val Asp Asn Gly Ser Gly Ala Val Leu Thr 
        275                 280                 285             


Ile Gln Ala Gly Ser Ser Phe Ser Gly Leu Leu Leu Gly Thr 
    290                 295                 300         


<210>  630
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  630

Met Gly Val Ala Ala Arg Pro Pro Ala Leu Arg His Trp Phe Ser His 
1               5                   10                  15      


Ser Ile Pro Leu Ala Ile Phe Ala Leu Leu Leu Leu Tyr Leu Ser Val 
            20                  25                  30          


Arg Ser Leu Gly Ala Arg Ser Gly Cys Gly Pro Arg Ala Gln Pro Cys 
        35                  40                  45              


Val Pro Gly Glu Thr Ala Pro Phe Gln Val Arg Gln Glu Ser Gly Thr 
    50                  55                  60                  


Leu Glu Ala Pro Glu Arg Lys Gln Pro Pro Cys Leu Gly Pro Arg Gly 
65                  70                  75                  80  


Met Leu Gly Arg Met Met Arg Arg Phe His Ala Ser Leu Lys Pro Glu 
                85                  90                  95      


Gly Asp Val Gly Leu Ser Pro Tyr Leu Ala Gly Trp Arg Ala Leu Val 
            100                 105                 110         


Glu Phe Leu Thr Pro Leu Gly Ser Val Phe Ala Phe Ala Thr Arg Glu 
        115                 120                 125             


Ala Phe Thr Lys Val Thr Asp Leu Glu Ala Arg Val His Gly Pro Asp 
    130                 135                 140                 


Ala Glu His Tyr Trp Ser Leu Val Ala Met Ala Ala Trp Glu Arg Arg 
145                 150                 155                 160 


Ala Gly Leu Leu Glu Gln Pro Gly Ala Ala Pro Arg Asp Pro Thr Arg 
                165                 170                 175     


Ser Ser Gly Ser Arg Thr Leu Leu Leu Leu His Arg Ala Leu Arg Trp 
            180                 185                 190         


Ser Gln Leu Cys Leu His Arg Val Ala Thr Gly Ala Leu Gly Gly Pro 
        195                 200                 205             


Glu Ala Gly Val Gln Cys Ser Asp Ala Tyr Arg Ala Ala Leu Gly Pro 
    210                 215                 220                 


His His Pro Trp Leu Val Arg Gln Thr Ala Arg Leu Ala Phe Leu Ala 
225                 230                 235                 240 


Phe Pro Gly Arg Arg Arg Leu Leu Glu Leu Ala Cys Pro Gly Ala Thr 
                245                 250                 255     


Glu Ala Glu Ala Arg Ala Ala Leu Leu Arg Ala Ala Gly Thr Leu Glu 
            260                 265                 270         


Asp Val Tyr Asn Arg Thr Gln Ser Leu Leu Ala Glu Arg Gly Leu Leu 
        275                 280                 285             


Gln Leu Ala 
    290     


<210>  631
<211>  719
<212>  PRT
<213>  Homo sapiens

<400>  631

Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg 
1               5                   10                  15      


Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe 
            20                  25                  30          


Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Asn Glu 
        35                  40                  45              


Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu 
    50                  55                  60                  


Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile 
65                  70                  75                  80  


Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile 
                85                  90                  95      


Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His 
            100                 105                 110         


Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile 
        115                 120                 125             


Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe 
    130                 135                 140                 


Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro 
145                 150                 155                 160 


Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr 
                165                 170                 175     


Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met 
            180                 185                 190         


Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val 
        195                 200                 205             


Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly 
    210                 215                 220                 


Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys 
225                 230                 235                 240 


Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly 
                245                 250                 255     


Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr 
            260                 265                 270         


Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly 
        275                 280                 285             


Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys 
    290                 295                 300                 


Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg 
305                 310                 315                 320 


Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn 
                325                 330                 335     


Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val 
            340                 345                 350         


Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro 
        355                 360                 365             


Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly 
    370                 375                 380                 


Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg 
385                 390                 395                 400 


Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile 
                405                 410                 415     


Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr 
            420                 425                 430         


Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala 
        435                 440                 445             


Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val 
    450                 455                 460                 


Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu 
465                 470                 475                 480 


Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser 
                485                 490                 495     


Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile 
            500                 505                 510         


Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu 
        515                 520                 525             


Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn 
    530                 535                 540                 


Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu 
545                 550                 555                 560 


Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val 
                565                 570                 575     


Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val 
            580                 585                 590         


Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala 
        595                 600                 605             


Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr 
    610                 615                 620                 


Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr 
625                 630                 635                 640 


Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser 
                645                 650                 655     


Lys His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu 
            660                 665                 670         


Ser Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val 
        675                 680                 685             


Asp Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala 
    690                 695                 700                 


Ala Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
705                 710                 715                 


<210>  632
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  632

Met Pro Ala Arg Ser Gly Ala Gln Phe Cys Arg Arg Met Gly Gln Lys 
1               5                   10                  15      


Lys Gln Arg Pro Ala Arg Ala Gly Gln Pro His Ser Ser Ser Asp Ala 
            20                  25                  30          


Ala Gln Ala Pro Ala Glu Gln Pro His Ser Ser Ser Asp Ala Ala Gln 
        35                  40                  45              


Ala Pro Cys Pro Arg Glu Arg Cys Leu Gly Pro Pro Thr Thr Pro Gly 
    50                  55                  60                  


Pro Tyr Arg Ser Ile Tyr Phe Ser Ser Pro Lys Gly His Leu Thr Arg 
65                  70                  75                  80  


Leu Gly Leu Glu Phe Phe Asp Gln Pro Ala Val Pro Leu Ala Arg Ala 
                85                  90                  95      


Phe Leu Gly Gln Val Leu Val Arg Arg Leu Pro Asn Gly Thr Glu Leu 
            100                 105                 110         


Arg Gly Arg Ile Val Glu Thr Glu Ala Tyr Leu Gly Pro Glu Asp Glu 
        115                 120                 125             


Ala Ala His Ser Arg Gly Gly Arg Gln Thr Pro Arg Asn Arg Gly Met 
    130                 135                 140                 


Phe Met Lys Pro Gly Thr Leu Tyr Val Tyr Ile Ile Tyr Gly Met Tyr 
145                 150                 155                 160 


Phe Cys Met Asn Ile Ser Ser Gln Gly Asp Gly Ala Cys Val Leu Leu 
                165                 170                 175     


Arg Ala Leu Glu Pro Leu Glu Gly Leu Glu Thr Met Arg Gln Leu Arg 
            180                 185                 190         


Ser Thr Leu Arg Lys Gly Thr Ala Ser Arg Val Leu Lys Asp Arg Glu 
        195                 200                 205             


Leu Cys Ser Gly Pro Ser Lys Leu Cys Gln Ala Leu Ala Ile Asn Lys 
    210                 215                 220                 


Ser Phe Asp Gln Arg Asp Leu Ala Gln Asp Glu Ala Val Trp Leu Glu 
225                 230                 235                 240 


Arg Gly Pro Leu Glu Pro Ser Glu Pro Ala Val Val Ala Ala Ala Arg 
                245                 250                 255     


Val Gly Val Gly His Ala Gly Glu Trp Ala Arg Lys Pro Leu Arg Phe 
            260                 265                 270         


Tyr Val Arg Gly Ser Pro Trp Val Ser Val Val Asp Arg Val Ala Glu 
        275                 280                 285             


Gln Asp Thr Gln Ala 
    290             


<210>  633
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  633

Met Gly Gln Lys Lys Gln Arg Pro Ala Arg Ala Gly Gln Pro His Ser 
1               5                   10                  15      


Ser Ser Asp Ala Ala Gln Ala Pro Ala Glu Gln Pro His Ser Ser Ser 
            20                  25                  30          


Asp Ala Ala Gln Ala Pro Cys Pro Arg Glu Arg Cys Leu Gly Pro Pro 
        35                  40                  45              


Thr Thr Pro Gly Pro Tyr Arg Ser Ile Tyr Phe Ser Ser Pro Lys Gly 
    50                  55                  60                  


His Leu Thr Arg Leu Gly Leu Glu Phe Phe Asp Gln Pro Ala Val Pro 
65                  70                  75                  80  


Leu Ala Arg Ala Phe Leu Gly Gln Val Leu Val Arg Arg Leu Pro Asn 
                85                  90                  95      


Gly Thr Glu Leu Arg Gly Arg Ile Val Glu Thr Glu Ala Tyr Leu Gly 
            100                 105                 110         


Pro Glu Asp Glu Ala Ala His Ser Arg Gly Gly Arg Gln Thr Pro Arg 
        115                 120                 125             


Asn Arg Gly Met Phe Met Lys Pro Gly Thr Leu Tyr Val Tyr Ile Ile 
    130                 135                 140                 


Tyr Gly Met Tyr Phe Cys Met Asn Ile Ser Ser Gln Gly Asp Gly Ala 
145                 150                 155                 160 


Cys Val Leu Leu Arg Ala Leu Glu Pro Leu Glu Gly Leu Glu Thr Met 
                165                 170                 175     


Arg Gln Leu Arg Ser Thr Leu Arg Lys Gly Thr Ala Ser Arg Val Leu 
            180                 185                 190         


Lys Asp Arg Glu Leu Cys Ser Gly Pro Ser Lys Leu Cys Gln Ala Leu 
        195                 200                 205             


Ala Ile Asn Lys Ser Phe Asp Gln Arg Asp Leu Ala Gln Asp Glu Ala 
    210                 215                 220                 


Val Trp Leu Glu Arg Gly Pro Leu Glu Pro Ser Glu Pro Ala Val Val 
225                 230                 235                 240 


Ala Ala Ala Arg Val Gly Val Gly His Ala Gly Glu Trp Ala Arg Lys 
                245                 250                 255     


Pro Leu Arg Phe Tyr Val Arg Gly Ser Pro Trp Val Ser Val Val Asp 
            260                 265                 270         


Arg Val Ala Glu Gln Asp Thr Gln Ala 
        275                 280     


<210>  634
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  634

Met Ser Leu Leu Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro His Glu Gly Val His Arg Lys Pro Ser Leu Leu 
            20                  25                  30          


Ala His Pro Gly Arg Leu Val Lys Ser Glu Glu Thr Val Ile Leu Gln 
        35                  40                  45              


Cys Trp Ser Asp Val Met Phe Glu His Phe Leu Leu His Arg Glu Gly 
    50                  55                  60                  


Met Phe Asn Asp Thr Leu Arg Leu Ile Gly Glu His His Asp Gly Val 
65                  70                  75                  80  


Ser Lys Ala Asn Phe Ser Ile Ser Arg Met Thr Gln Asp Leu Ala Gly 
                85                  90                  95      


Thr Tyr Arg Cys Tyr Gly Ser Val Thr His Ser Pro Tyr Gln Val Ser 
            100                 105                 110         


Ala Pro Ser Asp Pro Leu Asp Ile Val Ile Ile Gly Leu Tyr Glu Lys 
        115                 120                 125             


Pro Ser Leu Ser Ala Gln Leu Gly Pro Thr Val Leu Ala Gly Glu Asn 
    130                 135                 140                 


Val Thr Leu Ser Cys Ser Ser Arg Ser Ser Tyr Asp Met Tyr His Leu 
145                 150                 155                 160 


Ser Arg Glu Gly Glu Ala His Glu Arg Arg Leu Pro Ala Gly Pro Lys 
                165                 170                 175     


Val Asn Gly Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His 
            180                 185                 190         


Gly Gly Thr Tyr Arg Cys Phe Gly Ser Phe His Asp Ser Pro Tyr Glu 
        195                 200                 205             


Trp Ser Lys Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro 
    210                 215                 220                 


Ser Asn Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Thr Gly Asn 
225                 230                 235                 240 


Pro Arg His Leu His Ile Leu Ile Gly Thr Ser Val Val Ile Ile Leu 
                245                 250                 255     


Phe Ile Leu Leu Phe Phe Leu Leu His Arg Trp Cys Ser Asn Lys Lys 
            260                 265                 270         


Asn Ala Ala Val Met Asp Gln Glu Ser Ala Gly Asn Arg Thr Ala Asn 
        275                 280                 285             


Ser Glu Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Thr Gln 
    290                 295                 300                 


Leu Asn His Cys Val Phe Thr Gln Arg Lys Ile Thr Arg Pro Ser Gln 
305                 310                 315                 320 


Arg Pro Lys Thr Pro Pro Thr Asp Ile Ile Val Tyr Thr Glu Leu Pro 
                325                 330                 335     


Asn Ala Glu Ser Arg Ser Lys Val Val Ser Cys Pro 
            340                 345             


<210>  635
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  635

Met Asp Leu Val Lys Asn His Leu Met Tyr Ala Val Arg Glu Glu Val 
1               5                   10                  15      


Glu Ile Leu Lys Glu Gln Ile Arg Glu Leu Val Glu Lys Asn Ser Gln 
            20                  25                  30          


Leu Glu Arg Glu Asn Thr Leu Leu Lys Thr Leu Ala Ser Pro Glu Gln 
        35                  40                  45              


Leu Glu Lys Phe Gln Ser Cys Leu Ser Pro Glu Glu Pro Ala Pro Glu 
    50                  55                  60                  


Ser Pro Gln Val Pro Glu Ala Pro Gly Gly Ser Ala Val 
65                  70                  75          


<210>  636
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  636

Met Gly Ala Pro Leu Leu Ser Pro Gly Trp Gly Ala Gly Ala Ala Gly 
1               5                   10                  15      


Arg Arg Trp Trp Met Leu Leu Ala Pro Leu Leu Pro Ala Leu Leu Leu 
            20                  25                  30          


Val Arg Pro Ala Gly Ala Leu Val Glu Gly Leu Tyr Cys Gly Thr Arg 
        35                  40                  45              


Asp Cys Tyr Glu Val Leu Gly Val Ser Arg Ser Ala Gly Lys Ala Glu 
    50                  55                  60                  


Ile Ala Arg Ala Tyr Arg Gln Leu Ala Arg Arg Tyr His Pro Asp Arg 
65                  70                  75                  80  


Tyr Arg Pro Gln Pro Gly Asp Glu Gly Pro Gly Arg Thr Pro Gln Ser 
                85                  90                  95      


Ala Glu Glu Ala Phe Leu Leu Val Ala Thr Ala Tyr Glu Thr Leu Lys 
            100                 105                 110         


Asp Glu Glu Thr Arg Lys Asp Tyr Asp Tyr Met Leu Asp His Pro Glu 
        115                 120                 125             


Glu Tyr Tyr Ser His Tyr Tyr His Tyr Tyr Ser Arg Arg Leu Ala Pro 
    130                 135                 140                 


Lys Val Asp Val Arg Val Val Ile Leu Val Ser Val Cys Ala Ile Ser 
145                 150                 155                 160 


Val Phe Gln Phe Phe Ser Trp Trp Asn Ser Tyr Asn Lys Ala Ile Ser 
                165                 170                 175     


Tyr Leu Ala Thr Val Pro Lys Tyr Arg Ile Gln Ala Thr Glu Ile Ala 
            180                 185                 190         


Lys Gln Gln Gly Leu Leu Lys Lys Ala Lys Glu Lys Gly Lys Asn Lys 
        195                 200                 205             


Lys Ser Lys Glu Glu Ile Arg Asp Glu Glu Glu Asn Ile Ile Lys Asn 
    210                 215                 220                 


Ile Ile Lys Ser Lys Ile Asp Ile Lys Gly Gly Tyr Gln Lys Pro Gln 
225                 230                 235                 240 


Ile Cys Asp Leu Leu Leu Phe Gln Ile Ile Leu Ala Pro Phe His Leu 
                245                 250                 255     


Cys Ser Tyr Ile Val Trp Tyr Cys Arg Trp Ile Tyr Asn Phe Asn Ile 
            260                 265                 270         


Lys Gly Lys Glu Tyr Gly Glu Glu Glu Arg Leu Tyr Ile Ile Arg Lys 
        275                 280                 285             


Ser Met Lys Met Ser Lys Ser Gln Phe Asp Ser Leu Glu Asp His Gln 
    290                 295                 300                 


Lys Glu Thr Phe Leu Lys Arg Glu Leu Trp Ile Lys Glu Asn Tyr Glu 
305                 310                 315                 320 


Val Tyr Lys Gln Glu Gln Glu Glu Glu Leu Lys Lys Lys Leu Ala Asn 
                325                 330                 335     


Asp Pro Arg Trp Lys Arg Tyr Arg Arg Trp Met Lys Asn Glu Gly Pro 
            340                 345                 350         


Gly Arg Leu Thr Phe Val Asp Asp 
        355                 360 


<210>  637
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  637

Met Thr Ser Gln Arg Ser Pro Leu Ala Pro Leu Leu Leu Leu Ser Leu 
1               5                   10                  15      


His Gly Val Ala Ala Ser Leu Glu Val Ser Glu Ser Pro Gly Ser Ile 
            20                  25                  30          


Gln Val Ala Arg Gly Gln Pro Ala Val Leu Pro Cys Thr Phe Thr Thr 
        35                  40                  45              


Ser Ala Ala Leu Ile Asn Leu Asn Val Ile Trp Met Val Thr Pro Leu 
    50                  55                  60                  


Ser Asn Ala Asn Gln Pro Glu Gln Val Ile Leu Tyr Gln Gly Gly Gln 
65                  70                  75                  80  


Met Phe Asp Gly Ala Pro Arg Phe His Gly Arg Val Gly Phe Thr Gly 
                85                  90                  95      


Thr Met Pro Ala Thr Asn Val Ser Ile Phe Ile Asn Asn Thr Gln Leu 
            100                 105                 110         


Ser Asp Thr Gly Thr Tyr Gln Cys Leu Val Asn Asn Leu Pro Asp Ile 
        115                 120                 125             


Gly Gly Arg Asn Ile Gly Val Thr Gly Leu Thr Val Leu Val Pro Pro 
    130                 135                 140                 


Ser Ala Pro His Cys Gln Ile Gln Gly Ser Gln Asp Ile Gly Ser Asp 
145                 150                 155                 160 


Val Ile Leu Leu Cys Ser Ser Glu Glu Gly Ile Pro Arg Pro Thr Tyr 
                165                 170                 175     


Leu Trp Glu Lys Leu Asp Asn Thr Leu Lys Leu Pro Pro Thr Ala Thr 
            180                 185                 190         


Gln Asp Gln Val Gln Gly Thr Val Thr Ile Arg Asn Ile Ser Ala Leu 
        195                 200                 205             


Ser Ser Gly Leu Tyr Gln Cys Val Ala Ser Asn Ala Ile Gly Thr Ser 
    210                 215                 220                 


Thr Cys Leu Leu Asp Leu Gln Val Ile Ser Pro Gln Pro Arg Asn Ile 
225                 230                 235                 240 


Gly Leu Ile Ala Gly Ala Ile Gly Thr Gly Ala Val Ile Ile Ile Phe 
                245                 250                 255     


Cys Ile Ala Leu Ile Leu Gly Ala Phe Phe Tyr Trp Arg Ser Lys Asn 
            260                 265                 270         


Lys Glu Glu Glu Glu Glu Glu Ile Pro Asn Glu Ile Arg Glu Asp Asp 
        275                 280                 285             


Leu Pro Pro Lys Cys Ser Ser Ala Lys Ala Phe His Thr Glu Ile Ser 
    290                 295                 300                 


Ser Ser Asp Asn Asn Thr Leu Thr Ser Ser Asn Ala Tyr Asn Ser Arg 
305                 310                 315                 320 


Tyr Trp Ser Asn Asn Pro Lys Val His Arg Asn Thr Glu Ser Val Ser 
                325                 330                 335     


His Phe Ser Asp Leu Gly Gln Ser Phe Ser Phe His Ser Gly Asn Ala 
            340                 345                 350         


Asn Ile Pro Ser Ile Tyr Ala Asn Gly Thr His Leu Val Pro Gly Gln 
        355                 360                 365             


His Lys Thr Leu Val Val Thr Ala Asn Arg Gly Ser Ser Pro Gln Val 
    370                 375                 380                 


Met Ser Arg Ser Asn Gly Ser Val Ser Arg Lys Pro Arg Pro Pro His 
385                 390                 395                 400 


Thr His Ser Tyr Thr Ile Ser His Ala Thr Leu Glu Arg Ile Gly Ala 
                405                 410                 415     


Val Pro Val Met Val Pro Ala Gln Ser Arg Ala Gly Ser Leu Val 
            420                 425                 430     


<210>  638
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  638

Met Gly Lys Cys Arg Gly Leu Arg Thr Ala Arg Lys Leu Arg Ser His 
1               5                   10                  15      


Arg Arg Asp Gln Lys Trp His Asp Lys Gln Tyr Lys Lys Ala His Leu 
            20                  25                  30          


Gly Thr Ala Leu Lys Ala Asn Pro Phe Gly Gly Ala Ser His Ala Lys 
        35                  40                  45              


Gly Ile Val Leu Glu Lys Val Gly Val Glu Ala Lys Gln Pro Asn Ser 
    50                  55                  60                  


Ala Ile Arg Lys Cys Val Arg Val Gln Leu Ile Lys Asn Gly Lys Lys 
65                  70                  75                  80  


Ile Thr Ala Phe Val Pro Asn Asp Gly Cys Leu Asn Phe Ile Glu Glu 
                85                  90                  95      


Asn Asp Glu Val Leu Val Ala Gly Phe Gly Arg Lys Gly His Ala Val 
            100                 105                 110         


Gly Asp Ile Pro Gly Val Arg Phe Lys Val Val Lys Val Ala Asn Val 
        115                 120                 125             


Ser Leu Leu Ala Leu Tyr Lys Gly Lys Lys Glu Arg Pro Arg Ser 
    130                 135                 140             


<210>  639
<211>  811
<212>  PRT
<213>  Homo sapiens

<400>  639

Met Arg Leu Ile Arg Asn Ile Tyr Ile Phe Cys Ser Ile Val Met Thr 
1               5                   10                  15      


Ala Glu Gly Asp Ala Pro Glu Leu Pro Glu Glu Arg Glu Leu Met Thr 
            20                  25                  30          


Asn Cys Ser Asn Met Ser Leu Arg Lys Val Pro Ala Asp Leu Thr Pro 
        35                  40                  45              


Ala Thr Thr Thr Leu Asp Leu Ser Tyr Asn Leu Leu Phe Gln Leu Gln 
    50                  55                  60                  


Ser Ser Asp Phe His Ser Val Ser Lys Leu Arg Val Leu Ile Leu Cys 
65                  70                  75                  80  


His Asn Arg Ile Gln Gln Leu Asp Leu Lys Thr Phe Glu Phe Asn Lys 
                85                  90                  95      


Glu Leu Arg Tyr Leu Asp Leu Ser Asn Asn Arg Leu Lys Ser Val Thr 
            100                 105                 110         


Trp Tyr Leu Leu Ala Gly Leu Arg Tyr Leu Asp Leu Ser Phe Asn Asp 
        115                 120                 125             


Phe Asp Thr Met Pro Ile Cys Glu Glu Ala Gly Asn Met Ser His Leu 
    130                 135                 140                 


Glu Ile Leu Gly Leu Ser Gly Ala Lys Ile Gln Lys Ser Asp Phe Gln 
145                 150                 155                 160 


Lys Ile Ala His Leu His Leu Asn Thr Val Phe Leu Gly Phe Arg Thr 
                165                 170                 175     


Leu Pro His Tyr Glu Glu Gly Ser Leu Pro Ile Leu Asn Thr Thr Lys 
            180                 185                 190         


Leu His Ile Val Leu Pro Met Asp Thr Asn Phe Trp Val Leu Leu Arg 
        195                 200                 205             


Asp Gly Ile Lys Thr Ser Lys Ile Leu Glu Met Thr Asn Ile Asp Gly 
    210                 215                 220                 


Lys Ser Gln Phe Val Ser Tyr Glu Met Gln Arg Asn Leu Ser Leu Glu 
225                 230                 235                 240 


Asn Ala Lys Thr Ser Val Leu Leu Leu Asn Lys Val Asp Leu Leu Trp 
                245                 250                 255     


Asp Asp Leu Phe Leu Ile Leu Gln Phe Val Trp His Thr Ser Val Glu 
            260                 265                 270         


His Phe Gln Ile Arg Asn Val Thr Phe Gly Gly Lys Ala Tyr Leu Asp 
        275                 280                 285             


His Asn Ser Phe Asp Tyr Ser Asn Thr Val Met Arg Thr Ile Lys Leu 
    290                 295                 300                 


Glu His Val His Phe Arg Val Phe Tyr Ile Gln Gln Asp Lys Ile Tyr 
305                 310                 315                 320 


Leu Leu Leu Thr Lys Met Asp Ile Glu Asn Leu Thr Ile Ser Asn Ala 
                325                 330                 335     


Gln Met Pro His Met Leu Phe Pro Asn Tyr Pro Thr Lys Phe Gln Tyr 
            340                 345                 350         


Leu Asn Phe Ala Asn Asn Ile Leu Thr Asp Glu Leu Phe Lys Arg Thr 
        355                 360                 365             


Ile Gln Leu Pro His Leu Lys Thr Leu Ile Leu Asn Gly Asn Lys Leu 
    370                 375                 380                 


Glu Thr Leu Ser Leu Val Ser Cys Phe Ala Asn Asn Thr Pro Leu Glu 
385                 390                 395                 400 


His Leu Asp Leu Ser Gln Asn Leu Leu Gln His Lys Asn Asp Glu Asn 
                405                 410                 415     


Cys Ser Trp Pro Glu Thr Val Val Asn Met Asn Leu Ser Tyr Asn Lys 
            420                 425                 430         


Leu Ser Asp Ser Val Phe Arg Cys Leu Pro Lys Ser Ile Gln Ile Leu 
        435                 440                 445             


Asp Leu Asn Asn Asn Gln Ile Gln Thr Val Pro Lys Glu Thr Ile His 
    450                 455                 460                 


Leu Met Ala Leu Arg Glu Leu Asn Ile Ala Phe Asn Phe Leu Thr Asp 
465                 470                 475                 480 


Leu Pro Gly Cys Ser His Phe Ser Arg Leu Ser Val Leu Asn Ile Glu 
                485                 490                 495     


Met Asn Phe Ile Leu Ser Pro Ser Leu Asp Phe Val Gln Ser Cys Gln 
            500                 505                 510         


Glu Val Lys Thr Leu Asn Ala Gly Arg Asn Pro Phe Arg Cys Thr Cys 
        515                 520                 525             


Glu Leu Lys Asn Phe Ile Gln Leu Glu Thr Tyr Ser Glu Val Met Met 
    530                 535                 540                 


Val Gly Trp Ser Asp Ser Tyr Thr Cys Glu Tyr Pro Leu Asn Leu Arg 
545                 550                 555                 560 


Gly Thr Arg Leu Lys Asp Val His Leu His Glu Leu Ser Cys Asn Thr 
                565                 570                 575     


Ala Leu Leu Ile Val Thr Ile Val Val Ile Met Leu Val Leu Gly Leu 
            580                 585                 590         


Ala Val Ala Phe Cys Cys Leu His Phe Asp Leu Pro Trp Tyr Leu Arg 
        595                 600                 605             


Met Leu Gly Gln Cys Thr Gln Thr Trp His Arg Val Arg Lys Thr Thr 
    610                 615                 620                 


Gln Glu Gln Leu Lys Arg Asn Val Arg Phe His Ala Phe Ile Ser Tyr 
625                 630                 635                 640 


Ser Glu His Asp Ser Leu Trp Val Lys Asn Glu Leu Ile Pro Asn Leu 
                645                 650                 655     


Glu Lys Glu Asp Gly Ser Ile Leu Ile Cys Leu Tyr Glu Ser Tyr Phe 
            660                 665                 670         


Asp Pro Gly Lys Ser Ile Ser Glu Asn Ile Val Ser Phe Ile Glu Lys 
        675                 680                 685             


Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Asn Glu 
    690                 695                 700                 


Trp Cys His Tyr Glu Phe Tyr Phe Ala His His Asn Leu Phe His Glu 
705                 710                 715                 720 


Asn Ser Asp His Ile Ile Leu Ile Leu Leu Glu Pro Ile Pro Phe Tyr 
                725                 730                 735     


Cys Ile Pro Thr Arg Tyr His Lys Leu Lys Ala Leu Leu Glu Lys Lys 
            740                 745                 750         


Ala Tyr Leu Glu Trp Pro Lys Asp Arg Arg Lys Cys Gly Leu Phe Trp 
        755                 760                 765             


Ala Asn Leu Arg Ala Ala Ile Asn Val Asn Val Leu Ala Thr Arg Glu 
    770                 775                 780                 


Met Tyr Glu Leu Gln Thr Phe Thr Glu Leu Asn Glu Glu Ser Arg Gly 
785                 790                 795                 800 


Ser Thr Ile Ser Leu Met Arg Thr Asp Cys Leu 
                805                 810     


<210>  640
<211>  653
<212>  PRT
<213>  Homo sapiens

<400>  640

Met Glu Pro Ser Gly Ser Glu Gln Leu Phe Glu Asp Pro Asp Pro Gly 
1               5                   10                  15      


Gly Lys Ser Gln Asp Ala Glu Ala Arg Lys Gln Thr Glu Ser Glu Gln 
            20                  25                  30          


Lys Leu Ser Lys Met Thr His Asn Ala Leu Glu Asn Ile Asn Val Ile 
        35                  40                  45              


Gly Gln Gly Leu Lys His Leu Phe Gln His Gln Arg Arg Arg Ser Ser 
    50                  55                  60                  


Val Ser Pro His Asp Val Gln Gln Ile Gln Ala Asp Pro Glu Pro Glu 
65                  70                  75                  80  


Met Asp Leu Glu Ser Gln Asn Ala Cys Ala Glu Ile Asp Gly Val Pro 
                85                  90                  95      


Thr His Pro Thr Ala Leu Asn Arg Val Leu Gln Gln Ile Arg Val Pro 
            100                 105                 110         


Pro Lys Met Lys Arg Gly Thr Ser Leu His Ser Arg Arg Gly Lys Pro 
        115                 120                 125             


Glu Ala Pro Lys Gly Ser Pro Gln Ile Asn Arg Lys Ser Gly Gln Glu 
    130                 135                 140                 


Met Thr Ala Val Met Gln Ser Gly Arg Pro Arg Ser Ser Ser Thr Thr 
145                 150                 155                 160 


Asp Ala Pro Thr Ser Ser Ala Met Met Glu Ile Ala Cys Ala Ala Ala 
                165                 170                 175     


Ala Ala Ala Ala Ala Cys Leu Pro Gly Glu Glu Gly Thr Ala Glu Arg 
            180                 185                 190         


Ile Glu Arg Leu Glu Val Ser Ser Leu Ala Gln Thr Ser Ser Ala Val 
        195                 200                 205             


Ala Ser Ser Thr Asp Gly Ser Ile His Thr Asp Ser Val Asp Gly Thr 
    210                 215                 220                 


Pro Asp Pro Gln Arg Thr Lys Ala Ala Ile Ala His Leu Gln Gln Lys 
225                 230                 235                 240 


Ile Leu Lys Leu Thr Glu Gln Ile Lys Ile Ala Gln Thr Ala Arg Asp 
                245                 250                 255     


Asp Asn Val Ala Glu Tyr Leu Lys Leu Ala Asn Ser Ala Asp Lys Gln 
            260                 265                 270         


Gln Ala Ala Arg Ile Lys Gln Val Phe Glu Lys Lys Asn Gln Lys Ser 
        275                 280                 285             


Ala Gln Thr Ile Leu Gln Leu Gln Lys Lys Leu Glu His Tyr His Arg 
    290                 295                 300                 


Lys Leu Arg Glu Val Glu Gln Asn Gly Ile Pro Arg Gln Pro Lys Asp 
305                 310                 315                 320 


Val Phe Arg Asp Met His Gln Gly Leu Lys Asp Val Gly Ala Lys Val 
                325                 330                 335     


Thr Gly Phe Ser Glu Gly Val Val Asp Ser Val Lys Gly Gly Phe Ser 
            340                 345                 350         


Ser Phe Ser Gln Ala Thr His Ser Ala Ala Gly Ala Val Val Ser Lys 
        355                 360                 365             


Pro Arg Glu Ile Ala Ser Leu Ile Arg Asn Lys Phe Gly Ser Ala Asp 
    370                 375                 380                 


Asn Ile Pro Asn Leu Lys Asp Ser Leu Glu Glu Gly Gln Val Asp Asp 
385                 390                 395                 400 


Ala Gly Lys Ala Leu Gly Val Ile Ser Asn Phe Gln Ser Ser Pro Lys 
                405                 410                 415     


Tyr Gly Ser Glu Glu Asp Cys Ser Ser Ala Thr Ser Gly Ser Val Gly 
            420                 425                 430         


Ala Asn Ser Thr Thr Gly Gly Ile Ala Val Gly Ala Ser Ser Ser Lys 
        435                 440                 445             


Thr Asn Thr Leu Asp Met Gln Ser Ser Gly Phe Asp Ala Leu Leu His 
    450                 455                 460                 


Glu Ile Gln Glu Ile Arg Glu Thr Gln Ala Arg Leu Glu Glu Ser Phe 
465                 470                 475                 480 


Glu Thr Leu Lys Glu His Tyr Gln Arg Asp Tyr Ser Leu Ile Met Gln 
                485                 490                 495     


Thr Leu Gln Glu Glu Arg Tyr Arg Cys Glu Arg Leu Glu Glu Gln Leu 
            500                 505                 510         


Asn Asp Leu Thr Glu Leu His Gln Asn Glu Ile Leu Asn Leu Lys Gln 
        515                 520                 525             


Glu Leu Ala Ser Met Glu Glu Lys Ile Ala Tyr Gln Ser Tyr Glu Arg 
    530                 535                 540                 


Ala Arg Asp Ile Gln Glu Ala Leu Glu Ala Cys Gln Thr Arg Ile Ser 
545                 550                 555                 560 


Lys Met Glu Leu Gln Gln Gln Gln Gln Gln Val Val Gln Leu Glu Gly 
                565                 570                 575     


Leu Glu Asn Ala Thr Ala Arg Asn Leu Leu Gly Lys Leu Ile Asn Ile 
            580                 585                 590         


Leu Leu Ala Val Met Ala Val Leu Leu Val Phe Val Ser Thr Val Ala 
        595                 600                 605             


Asn Cys Val Val Pro Leu Met Lys Thr Arg Asn Arg Thr Phe Ser Thr 
    610                 615                 620                 


Leu Phe Leu Val Val Phe Ile Ala Phe Leu Trp Lys His Trp Asp Ala 
625                 630                 635                 640 


Leu Phe Ser Tyr Val Glu Arg Phe Phe Ser Ser Pro Arg 
                645                 650             


<210>  641
<211>  967
<212>  PRT
<213>  Homo sapiens

<400>  641

Met Pro Ser Pro Pro Gly Leu Arg Ala Leu Trp Leu Cys Ala Ala Leu 
1               5                   10                  15      


Cys Ala Ser Arg Arg Ala Gly Gly Ala Pro Gln Pro Gly Pro Gly Pro 
            20                  25                  30          


Thr Ala Cys Pro Ala Pro Cys His Cys Gln Glu Asp Gly Ile Met Leu 
        35                  40                  45              


Ser Ala Asp Cys Ser Glu Leu Gly Leu Ser Ala Val Pro Gly Asp Leu 
    50                  55                  60                  


Asp Pro Leu Thr Ala Tyr Leu Asp Leu Ser Met Asn Asn Leu Thr Glu 
65                  70                  75                  80  


Leu Gln Pro Gly Leu Phe His His Leu Arg Phe Leu Glu Glu Leu Arg 
                85                  90                  95      


Leu Ser Gly Asn His Leu Ser His Ile Pro Gly Gln Ala Phe Ser Gly 
            100                 105                 110         


Leu Tyr Ser Leu Lys Ile Leu Met Leu Gln Asn Asn Gln Leu Gly Gly 
        115                 120                 125             


Ile Pro Ala Glu Ala Leu Trp Glu Leu Pro Ser Leu Gln Ser Leu Arg 
    130                 135                 140                 


Leu Asp Ala Asn Leu Ile Ser Leu Val Pro Glu Arg Ser Phe Glu Gly 
145                 150                 155                 160 


Leu Ser Ser Leu Arg His Leu Trp Leu Asp Asp Asn Ala Leu Thr Glu 
                165                 170                 175     


Ile Pro Val Arg Ala Leu Asn Asn Leu Pro Ala Leu Gln Ala Met Thr 
            180                 185                 190         


Leu Ala Leu Asn Arg Ile Ser His Ile Pro Asp Tyr Ala Phe Gln Asn 
        195                 200                 205             


Leu Thr Ser Leu Val Val Leu His Leu His Asn Asn Arg Ile Gln His 
    210                 215                 220                 


Leu Gly Thr His Ser Phe Glu Gly Leu His Asn Leu Glu Thr Leu Asp 
225                 230                 235                 240 


Leu Asn Tyr Asn Lys Leu Gln Glu Phe Pro Val Ala Ile Arg Thr Leu 
                245                 250                 255     


Gly Arg Leu Gln Glu Leu Gly Phe His Asn Asn Asn Ile Lys Ala Ile 
            260                 265                 270         


Pro Glu Lys Ala Phe Met Gly Asn Pro Leu Leu Gln Thr Ile His Phe 
        275                 280                 285             


Tyr Asp Asn Pro Ile Gln Phe Val Gly Arg Ser Ala Phe Gln Tyr Leu 
    290                 295                 300                 


Pro Lys Leu His Thr Leu Ser Leu Asn Gly Ala Met Asp Ile Gln Glu 
305                 310                 315                 320 


Phe Pro Asp Leu Lys Gly Thr Thr Ser Leu Glu Ile Leu Thr Leu Thr 
                325                 330                 335     


Arg Ala Gly Ile Arg Leu Leu Pro Ser Gly Met Cys Gln Gln Leu Pro 
            340                 345                 350         


Arg Leu Arg Val Leu Glu Leu Ser His Asn Gln Ile Glu Glu Leu Pro 
        355                 360                 365             


Ser Leu His Arg Cys Gln Lys Leu Glu Glu Ile Gly Leu Gln His Asn 
    370                 375                 380                 


Arg Ile Trp Glu Ile Gly Ala Asp Thr Phe Ser Gln Leu Ser Ser Leu 
385                 390                 395                 400 


Gln Ala Leu Asp Leu Ser Trp Asn Ala Ile Arg Ser Ile His Pro Glu 
                405                 410                 415     


Ala Phe Ser Thr Leu His Ser Leu Val Lys Leu Asp Leu Thr Asp Asn 
            420                 425                 430         


Gln Leu Thr Thr Leu Pro Leu Ala Gly Leu Gly Gly Leu Met His Leu 
        435                 440                 445             


Lys Leu Lys Gly Asn Leu Ala Leu Ser Gln Ala Phe Ser Lys Asp Ser 
    450                 455                 460                 


Phe Pro Lys Leu Arg Ile Leu Glu Val Pro Tyr Ala Tyr Gln Cys Cys 
465                 470                 475                 480 


Pro Tyr Gly Met Cys Ala Ser Phe Phe Lys Ala Ser Gly Gln Trp Glu 
                485                 490                 495     


Ala Glu Asp Leu His Leu Asp Asp Glu Glu Ser Ser Lys Arg Pro Leu 
            500                 505                 510         


Gly Leu Leu Ala Arg Gln Ala Glu Asn His Tyr Asp Gln Asp Leu Asp 
        515                 520                 525             


Glu Leu Gln Leu Glu Met Glu Asp Ser Lys Pro His Pro Ser Val Gln 
    530                 535                 540                 


Cys Ser Pro Thr Pro Gly Pro Phe Lys Pro Cys Glu Tyr Leu Phe Glu 
545                 550                 555                 560 


Ser Trp Gly Ile Arg Leu Ala Val Trp Ala Ile Val Leu Leu Ser Val 
                565                 570                 575     


Leu Cys Asn Gly Leu Val Leu Leu Thr Val Phe Ala Gly Gly Pro Val 
            580                 585                 590         


Pro Leu Pro Pro Val Lys Phe Val Val Gly Ala Ile Ala Gly Ala Asn 
        595                 600                 605             


Thr Leu Thr Gly Ile Ser Cys Gly Leu Leu Ala Ser Val Asp Ala Leu 
    610                 615                 620                 


Thr Phe Gly Gln Phe Ser Glu Tyr Gly Ala Arg Trp Glu Thr Gly Leu 
625                 630                 635                 640 


Gly Cys Arg Ala Thr Gly Phe Leu Ala Val Leu Gly Ser Glu Ala Ser 
                645                 650                 655     


Val Leu Leu Leu Thr Leu Ala Ala Val Gln Cys Ser Val Ser Val Ser 
            660                 665                 670         


Cys Val Arg Ala Tyr Gly Lys Ser Pro Ser Leu Gly Ser Val Arg Ala 
        675                 680                 685             


Gly Val Leu Gly Cys Leu Ala Leu Ala Gly Leu Ala Ala Ala Leu Pro 
    690                 695                 700                 


Leu Ala Ser Val Gly Glu Tyr Gly Ala Ser Pro Leu Cys Leu Pro Tyr 
705                 710                 715                 720 


Ala Pro Pro Glu Gly Gln Pro Ala Ala Leu Gly Phe Thr Val Ala Leu 
                725                 730                 735     


Val Met Met Asn Ser Phe Cys Phe Leu Val Val Ala Gly Ala Tyr Ile 
            740                 745                 750         


Lys Leu Tyr Cys Asp Leu Pro Arg Gly Asp Phe Glu Ala Val Trp Asp 
        755                 760                 765             


Cys Ala Met Val Arg His Val Ala Trp Leu Ile Phe Ala Asp Gly Leu 
    770                 775                 780                 


Leu Tyr Cys Pro Val Ala Phe Leu Ser Phe Ala Ser Met Leu Gly Leu 
785                 790                 795                 800 


Phe Pro Val Thr Pro Glu Ala Val Lys Ser Val Leu Leu Val Val Leu 
                805                 810                 815     


Pro Leu Pro Ala Cys Leu Asn Pro Leu Leu Tyr Leu Leu Phe Asn Pro 
            820                 825                 830         


His Phe Arg Asp Asp Leu Arg Arg Leu Arg Pro Arg Ala Gly Asp Ser 
        835                 840                 845             


Gly Pro Leu Ala Tyr Ala Ala Ala Gly Glu Leu Glu Lys Ser Ser Cys 
    850                 855                 860                 


Asp Ser Thr Gln Ala Leu Val Ala Phe Ser Asp Val Asp Leu Ile Leu 
865                 870                 875                 880 


Glu Ala Ser Glu Ala Gly Arg Pro Pro Gly Leu Glu Thr Tyr Gly Phe 
                885                 890                 895     


Pro Ser Val Thr Leu Ile Ser Cys Gln Gln Pro Gly Ala Pro Arg Leu 
            900                 905                 910         


Glu Gly Ser His Cys Val Glu Pro Glu Gly Asn His Phe Gly Asn Pro 
        915                 920                 925             


Gln Pro Ser Met Asp Gly Glu Leu Leu Leu Arg Ala Glu Gly Ser Thr 
    930                 935                 940                 


Pro Ala Gly Gly Gly Leu Ser Gly Gly Gly Gly Phe Gln Pro Ser Gly 
945                 950                 955                 960 


Leu Ala Phe Ala Ser His Val 
                965         


<210>  642
<211>  828
<212>  PRT
<213>  Homo sapiens

<400>  642

Met Arg Leu Glu Gly Glu Gly Arg Ser Ala Arg Ala Gly Gln Asn Leu 
1               5                   10                  15      


Ser Arg Ala Gly Ser Ala Arg Arg Gly Ala Pro Arg Asp Leu Ser Met 
            20                  25                  30          


Asn Asn Leu Thr Glu Leu Gln Pro Gly Leu Phe His His Leu Arg Phe 
        35                  40                  45              


Leu Glu Glu Leu Arg Leu Ser Gly Asn His Leu Ser His Ile Pro Gly 
    50                  55                  60                  


Gln Ala Phe Ser Gly Leu Tyr Ser Leu Lys Ile Leu Met Leu Gln Asn 
65                  70                  75                  80  


Asn Gln Leu Gly Gly Ile Pro Ala Glu Ala Leu Trp Glu Leu Pro Ser 
                85                  90                  95      


Leu Gln Ser Leu Asp Leu Asn Tyr Asn Lys Leu Gln Glu Phe Pro Val 
            100                 105                 110         


Ala Ile Arg Thr Leu Gly Arg Leu Gln Glu Leu Gly Phe His Asn Asn 
        115                 120                 125             


Asn Ile Lys Ala Ile Pro Glu Lys Ala Phe Met Gly Asn Pro Leu Leu 
    130                 135                 140                 


Gln Thr Ile His Phe Tyr Asp Asn Pro Ile Gln Phe Val Gly Arg Ser 
145                 150                 155                 160 


Ala Phe Gln Tyr Leu Pro Lys Leu His Thr Leu Ser Leu Asn Gly Ala 
                165                 170                 175     


Met Asp Ile Gln Glu Phe Pro Asp Leu Lys Gly Thr Thr Ser Leu Glu 
            180                 185                 190         


Ile Leu Thr Leu Thr Arg Ala Gly Ile Arg Leu Leu Pro Ser Gly Met 
        195                 200                 205             


Cys Gln Gln Leu Pro Arg Leu Arg Val Leu Glu Leu Ser His Asn Gln 
    210                 215                 220                 


Ile Glu Glu Leu Pro Ser Leu His Arg Cys Gln Lys Leu Glu Glu Ile 
225                 230                 235                 240 


Gly Leu Gln His Asn Arg Ile Trp Glu Ile Gly Ala Asp Thr Phe Ser 
                245                 250                 255     


Gln Leu Ser Ser Leu Gln Ala Leu Asp Leu Ser Trp Asn Ala Ile Arg 
            260                 265                 270         


Ser Ile His Pro Glu Ala Phe Ser Thr Leu His Ser Leu Val Lys Leu 
        275                 280                 285             


Asp Leu Thr Asp Asn Gln Leu Thr Thr Leu Pro Leu Ala Gly Leu Gly 
    290                 295                 300                 


Gly Leu Met His Leu Lys Leu Lys Gly Asn Leu Ala Leu Ser Gln Ala 
305                 310                 315                 320 


Phe Ser Lys Asp Ser Phe Pro Lys Leu Arg Ile Leu Glu Val Pro Tyr 
                325                 330                 335     


Ala Tyr Gln Cys Cys Pro Tyr Gly Met Cys Ala Ser Phe Phe Lys Ala 
            340                 345                 350         


Ser Gly Gln Trp Glu Ala Glu Asp Leu His Leu Asp Asp Glu Glu Ser 
        355                 360                 365             


Ser Lys Arg Pro Leu Gly Leu Leu Ala Arg Gln Ala Glu Asn His Tyr 
    370                 375                 380                 


Asp Gln Asp Leu Asp Glu Leu Gln Leu Glu Met Glu Asp Ser Lys Pro 
385                 390                 395                 400 


His Pro Ser Val Gln Cys Ser Pro Thr Pro Gly Pro Phe Lys Pro Cys 
                405                 410                 415     


Glu Tyr Leu Phe Glu Ser Trp Gly Ile Arg Leu Ala Val Trp Ala Ile 
            420                 425                 430         


Val Leu Leu Ser Val Leu Cys Asn Gly Leu Val Leu Leu Thr Val Phe 
        435                 440                 445             


Ala Gly Gly Pro Val Pro Leu Pro Pro Val Lys Phe Val Val Gly Ala 
    450                 455                 460                 


Ile Ala Gly Ala Asn Thr Leu Thr Gly Ile Ser Cys Gly Leu Leu Ala 
465                 470                 475                 480 


Ser Val Asp Ala Leu Thr Phe Gly Gln Phe Ser Glu Tyr Gly Ala Arg 
                485                 490                 495     


Trp Glu Thr Gly Leu Gly Cys Arg Ala Thr Gly Phe Leu Ala Val Leu 
            500                 505                 510         


Gly Ser Glu Ala Ser Val Leu Leu Leu Thr Leu Ala Ala Val Gln Cys 
        515                 520                 525             


Ser Val Ser Val Ser Cys Val Arg Ala Tyr Gly Lys Ser Pro Ser Leu 
    530                 535                 540                 


Gly Ser Val Arg Ala Gly Val Leu Gly Cys Leu Ala Leu Ala Gly Leu 
545                 550                 555                 560 


Ala Ala Ala Leu Pro Leu Ala Ser Val Gly Glu Tyr Gly Ala Ser Pro 
                565                 570                 575     


Leu Cys Leu Pro Tyr Ala Pro Pro Glu Gly Gln Pro Ala Ala Leu Gly 
            580                 585                 590         


Phe Thr Val Ala Leu Val Met Met Asn Ser Phe Cys Phe Leu Val Val 
        595                 600                 605             


Ala Gly Ala Tyr Ile Lys Leu Tyr Cys Asp Leu Pro Arg Gly Asp Phe 
    610                 615                 620                 


Glu Ala Val Trp Asp Cys Ala Met Val Arg His Val Ala Trp Leu Ile 
625                 630                 635                 640 


Phe Ala Asp Gly Leu Leu Tyr Cys Pro Val Ala Phe Leu Ser Phe Ala 
                645                 650                 655     


Ser Met Leu Gly Leu Phe Pro Val Thr Pro Glu Ala Val Lys Ser Val 
            660                 665                 670         


Leu Leu Val Val Leu Pro Leu Pro Ala Cys Leu Asn Pro Leu Leu Tyr 
        675                 680                 685             


Leu Leu Phe Asn Pro His Phe Arg Asp Asp Leu Arg Arg Leu Arg Pro 
    690                 695                 700                 


Arg Ala Gly Asp Ser Gly Pro Leu Ala Tyr Ala Ala Ala Gly Glu Leu 
705                 710                 715                 720 


Glu Lys Ser Ser Cys Asp Ser Thr Gln Ala Leu Val Ala Phe Ser Asp 
                725                 730                 735     


Val Asp Leu Ile Leu Glu Ala Ser Glu Ala Gly Arg Pro Pro Gly Leu 
            740                 745                 750         


Glu Thr Tyr Gly Phe Pro Ser Val Thr Leu Ile Ser Cys Gln Gln Pro 
        755                 760                 765             


Gly Ala Pro Arg Leu Glu Gly Ser His Cys Val Glu Pro Glu Gly Asn 
    770                 775                 780                 


His Phe Gly Asn Pro Gln Pro Ser Met Asp Gly Glu Leu Leu Leu Arg 
785                 790                 795                 800 


Ala Glu Gly Ser Thr Pro Ala Gly Gly Gly Leu Ser Gly Gly Gly Gly 
                805                 810                 815     


Phe Gln Pro Ser Gly Leu Ala Phe Ala Ser His Val 
            820                 825             


<210>  643
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  643

Met Met Asn Pro Arg Ala Lys Arg Asp Phe Tyr Leu Ala Ala Pro Asp 
1               5                   10                  15      


Leu Leu Asp Pro Lys Ser Ala Ala Gln Asn Ser Lys Pro Arg Leu Ser 
            20                  25                  30          


Phe Ser Thr Lys Pro Thr Val Leu Ala Ser Arg Val Glu Ser Asp Thr 
        35                  40                  45              


Thr Ile Asn Val Met Lys Trp Lys Thr Val Ser Thr Ile Phe Leu Val 
    50                  55                  60                  


Val Val Leu Tyr Leu Ile Ile Gly Ala Thr Val Phe Lys Ala Leu Glu 
65                  70                  75                  80  


Gln Pro His Glu Ile Ser Gln Arg Thr Thr Ile Val Ile Gln Lys Gln 
                85                  90                  95      


Thr Phe Ile Ser Gln His Ser Cys Val Asn Ser Thr Glu Leu Asp Glu 
            100                 105                 110         


Leu Ile Gln Gln Ile Val Ala Ala Ile Asn Ala Gly Ile Ile Pro Leu 
        115                 120                 125             


Gly Asn Thr Ser Asn Gln Ile Ser His Trp Asp Leu Gly Ser Ser Phe 
    130                 135                 140                 


Phe Phe Ala Gly Thr Val Ile Thr Thr Ile Gly Phe Gly Asn Ile Ser 
145                 150                 155                 160 


Pro Arg Thr Glu Gly Gly Lys Ile Phe Cys Ile Ile Tyr Ala Leu Leu 
                165                 170                 175     


Gly Ile Pro Leu Phe Gly Phe Leu Leu Ala Gly Val Gly Asp Gln Leu 
            180                 185                 190         


Gly Thr Ile Phe Gly Lys Gly Ile Ala Lys Val Glu Asp Thr Phe Ile 
        195                 200                 205             


Lys Trp Asn Val Ser Gln Thr Lys Ile Arg Ile Ile Ser Thr Ile Ile 
    210                 215                 220                 


Phe Ile Leu Phe Gly Cys Val Leu Phe Val Ala Leu Pro Ala Ile Ile 
225                 230                 235                 240 


Phe Lys His Ile Glu Gly Trp Ser Ala Leu Asp Ala Ile Tyr Phe Val 
                245                 250                 255     


Val Ile Thr Leu Thr Thr Ile Gly Phe Gly Asp Tyr Val Ala Gly Gly 
            260                 265                 270         


Ser Asp Ile Glu Tyr Leu Asp Phe Tyr Lys Pro Val Val Trp Phe Trp 
        275                 280                 285             


Ile Leu Val Gly Leu Ala Tyr Phe Ala Ala Val Leu Ser Met Ile Gly 
    290                 295                 300                 


Asp Trp Leu Arg Val Ile Ser Lys Lys Thr Lys Glu Glu Val Gly Glu 
305                 310                 315                 320 


Phe Arg Ala His Ala Ala Glu Trp Thr Ala Asn Val Thr Ala Glu Phe 
                325                 330                 335     


Lys Glu Thr Arg Arg Arg Leu Ser Val Glu Ile Tyr Asp Lys Phe Gln 
            340                 345                 350         


Arg Ala Thr Ser Ile Lys Arg Lys Leu Ser Ala Glu Leu Ala Gly Asn 
        355                 360                 365             


His Asn Gln Glu Leu Thr Pro Cys Arg Arg Thr Leu Ser Val Asn His 
    370                 375                 380                 


Leu Thr Ser Glu Arg Asp Val Leu Pro Pro Leu Leu Lys Thr Glu Ser 
385                 390                 395                 400 


Ile Tyr Leu Asn Gly Leu Thr Pro His Cys Ala Gly Glu Glu Ile Ala 
                405                 410                 415     


Val Ile Glu Asn Ile Lys 
            420         


<210>  644
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  644

Met Leu Pro Ser Ala Ser Arg Glu Arg Pro Gly Tyr Arg Ala Gly Val 
1               5                   10                  15      


Ala Ala Pro Asp Leu Leu Asp Pro Lys Ser Ala Ala Gln Asn Ser Lys 
            20                  25                  30          


Pro Arg Leu Ser Phe Ser Thr Lys Pro Thr Val Leu Ala Ser Arg Val 
        35                  40                  45              


Glu Ser Asp Thr Thr Ile Asn Val Met Lys Trp Lys Thr Val Ser Thr 
    50                  55                  60                  


Ile Phe Leu Val Val Val Leu Tyr Leu Ile Ile Gly Ala Thr Val Phe 
65                  70                  75                  80  


Lys Ala Leu Glu Gln Pro His Glu Ile Ser Gln Arg Thr Thr Ile Val 
                85                  90                  95      


Ile Gln Lys Gln Thr Phe Ile Ser Gln His Ser Cys Val Asn Ser Thr 
            100                 105                 110         


Glu Leu Asp Glu Leu Ile Gln Gln Ile Val Ala Ala Ile Asn Ala Gly 
        115                 120                 125             


Ile Ile Pro Leu Gly Asn Thr Ser Asn Gln Ile Ser His Trp Asp Leu 
    130                 135                 140                 


Gly Ser Ser Phe Phe Phe Ala Gly Thr Val Ile Thr Thr Ile Gly Phe 
145                 150                 155                 160 


Gly Asn Ile Ser Pro Arg Thr Glu Gly Gly Lys Ile Phe Cys Ile Ile 
                165                 170                 175     


Tyr Ala Leu Leu Gly Ile Pro Leu Phe Gly Phe Leu Leu Ala Gly Val 
            180                 185                 190         


Gly Asp Gln Leu Gly Thr Ile Phe Gly Lys Gly Ile Ala Lys Val Glu 
        195                 200                 205             


Asp Thr Phe Ile Lys Trp Asn Val Ser Gln Thr Lys Ile Arg Ile Ile 
    210                 215                 220                 


Ser Thr Ile Ile Phe Ile Leu Phe Gly Cys Val Leu Phe Val Ala Leu 
225                 230                 235                 240 


Pro Ala Ile Ile Phe Lys His Ile Glu Gly Trp Ser Ala Leu Asp Ala 
                245                 250                 255     


Ile Tyr Phe Val Val Ile Thr Leu Thr Thr Ile Gly Phe Gly Asp Tyr 
            260                 265                 270         


Val Ala Gly Gly Ser Asp Ile Glu Tyr Leu Asp Phe Tyr Lys Pro Val 
        275                 280                 285             


Val Trp Phe Trp Ile Leu Val Gly Leu Ala Tyr Phe Ala Ala Val Leu 
    290                 295                 300                 


Ser Met Ile Gly Asp Trp Leu Arg Val Ile Ser Lys Lys Thr Lys Glu 
305                 310                 315                 320 


Glu Val Gly Glu Phe Arg Ala His Ala Ala Glu Trp Thr Ala Asn Val 
                325                 330                 335     


Thr Ala Glu Phe Lys Glu Thr Arg Arg Arg Leu Ser Val Glu Ile Tyr 
            340                 345                 350         


Asp Lys Phe Gln Arg Ala Thr Ser Ile Lys Arg Lys Leu Ser Ala Glu 
        355                 360                 365             


Leu Ala Gly Asn His Asn Gln Glu Leu Thr Pro Cys Arg Arg Thr Leu 
    370                 375                 380                 


Ser Val Asn His Leu Thr Ser Glu Arg Asp Val Leu Pro Pro Leu Leu 
385                 390                 395                 400 


Lys Thr Glu Ser Ile Tyr Leu Asn Gly Leu Thr Pro His Cys Ala Gly 
                405                 410                 415     


Glu Glu Ile Ala Val Ile Glu Asn Ile Lys 
            420                 425     


<210>  645
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  645

Met Pro Phe His His Val Thr Ala Gly Leu Leu Tyr Lys Gly Asn Tyr 
1               5                   10                  15      


Leu Asn Arg Ser Leu Ser Ala Gly Ser Asp Ser Glu Gln Leu Ala Asn 
            20                  25                  30          


Ile Ser Val Glu Glu Leu Asp Glu Ile Arg Glu Ala Phe Arg Val Leu 
        35                  40                  45              


Asp Arg Asp Gly Asn Gly Phe Ile Ser Lys Gln Glu Leu Gly Met Ala 
    50                  55                  60                  


Met Arg Ser Leu Gly Tyr Met Pro Ser Glu Val Glu Leu Ala Ile Ile 
65                  70                  75                  80  


Met Gln Arg Leu Asp Met Asp Gly Asp Gly Gln Val Asp Phe Asp Glu 
                85                  90                  95      


Phe Met Thr Ile Leu Gly Pro Lys Leu Val Ser Ser Glu Gly Arg Asp 
            100                 105                 110         


Gly Phe Leu Gly Asn Thr Ile Asp Ser Ile Phe Trp Gln Phe Asp Met 
        115                 120                 125             


Gln Arg Ile Thr Leu Glu Glu Leu Lys His Ile Leu Tyr His Ala Phe 
    130                 135                 140                 


Arg Asp His Leu Thr Met Lys Asp Ile Glu Asn Ile Ile Ile Asn Glu 
145                 150                 155                 160 


Glu Glu Ser Leu Asn Glu Thr Ser Gly Asn Cys Gln Thr Glu Phe Glu 
                165                 170                 175     


Gly Val His Ser Gln Lys Gln Asn Arg Gln Thr Cys Val Arg Lys Ser 
            180                 185                 190         


Leu Ile Cys Ala Phe Ala Met Ala Phe Ile Ile Ser Val Met Leu Ile 
        195                 200                 205             


Ala Ala Asn Gln Ile Leu Arg Ser Gly Met Glu 
    210                 215                 


<210>  646
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  646

Met Glu Gly Gly Ala Ala Ala Ala Thr Pro Thr Ala Leu Pro Tyr Tyr 
1               5                   10                  15      


Val Ala Phe Ser Gln Leu Leu Gly Leu Thr Leu Val Ala Met Thr Gly 
            20                  25                  30          


Ala Trp Leu Gly Leu Tyr Arg Gly Gly Ile Ala Trp Glu Ser Asp Leu 
        35                  40                  45              


Gln Phe Asn Ala His Pro Leu Cys Met Val Ile Gly Leu Ile Phe Leu 
    50                  55                  60                  


Gln Gly Asn Ala Leu Leu Val Tyr Arg Val Phe Arg Asn Glu Ala Lys 
65                  70                  75                  80  


Arg Thr Thr Lys Val Leu His Gly Leu Leu His Ile Phe Ala Leu Val 
                85                  90                  95      


Ile Ala Leu Val Gly Leu Val Ala Val Phe Asp Tyr His Arg Lys Lys 
            100                 105                 110         


Gly Tyr Ala Asp Leu Tyr Ser Leu His Ser Trp Cys Gly Ile Leu Val 
        115                 120                 125             


Phe Val Leu Tyr Phe Val Gln Trp Leu Val Gly Phe Ser Phe Phe Leu 
    130                 135                 140                 


Phe Pro Gly Ala Ser Phe Ser Leu Arg Ser Arg Tyr Arg Pro Gln His 
145                 150                 155                 160 


Ile Phe Phe Gly Ala Thr Ile Phe Leu Leu Ser Val Gly Thr Ala Leu 
                165                 170                 175     


Leu Gly Leu Lys Glu Ala Leu Leu Phe Asn Leu Gly Gly Lys Tyr Ser 
            180                 185                 190         


Ala Phe Glu Pro Glu Gly Val Leu Ala Asn Val Leu Gly Leu Leu Leu 
        195                 200                 205             


Ala Cys Phe Gly Gly Ala Val Leu Tyr Ile Leu Thr Arg Ala Asp Trp 
    210                 215                 220                 


Lys Arg Pro Ser Gln Ala Glu Glu Gln Ala Leu Ser Met Asp Phe Lys 
225                 230                 235                 240 


Thr Leu Thr Glu Gly Asp Ser Pro Gly Ser Gln 
                245                 250     


<210>  647
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  647

Met Glu Gly Gly Ala Ala Ala Ala Thr Pro Thr Ala Leu Pro Tyr Tyr 
1               5                   10                  15      


Val Ala Phe Ser Gln Leu Leu Gly Leu Thr Leu Val Ala Met Thr Gly 
            20                  25                  30          


Ala Trp Leu Gly Leu Tyr Arg Gly Gly Ile Ala Trp Glu Ser Asp Leu 
        35                  40                  45              


Gln Phe Asn Ala His Pro Leu Cys Met Val Ile Gly Leu Ile Phe Leu 
    50                  55                  60                  


Gln Gly Asn Ala Leu Leu Val Tyr Arg Val Phe Arg Asn Glu Ala Lys 
65                  70                  75                  80  


Arg Thr Thr Lys Val Leu His Gly Leu Leu His Ile Phe Ala Leu Val 
                85                  90                  95      


Ile Ala Leu Val Gly Leu Val Ala Val Phe Asp Tyr His Arg Lys Lys 
            100                 105                 110         


Gly Tyr Ala Asp Leu Tyr Ser Leu His Ser Trp Cys Gly Ile Leu Val 
        115                 120                 125             


Phe Val Leu Tyr Phe Val Gln Trp Leu Val Gly Phe Ser Phe Phe Leu 
    130                 135                 140                 


Phe Pro Gly Ala Ser Phe Ser Leu Arg Ser Arg Tyr Arg Pro Gln His 
145                 150                 155                 160 


Ile Phe Phe Gly Ala Thr Ile Phe Leu Leu Ser Val Gly Thr Ala Leu 
                165                 170                 175     


Leu Gly Leu Lys Glu Ala Leu Leu Phe Asn Leu Gly Gly Lys Tyr Ser 
            180                 185                 190         


Ala Phe Glu Pro Glu Gly Val Leu Ala Asn Val Leu Gly Leu Leu Leu 
        195                 200                 205             


Ala Cys Phe Gly Gly Ala Val Leu Tyr Ile Leu Thr Arg Ala Asp Trp 
    210                 215                 220                 


Lys Arg Pro Ser Gln Ala Glu Glu Gln Ala Leu Ser Met Asp Phe Lys 
225                 230                 235                 240 


Thr Leu Thr Glu Gly Asp Ser Pro Gly Ser Gln 
                245                 250     


<210>  648
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  648

Met Ala Asn Glu Val Gln Asp Leu Leu Ser Pro Arg Lys Gly Gly His 
1               5                   10                  15      


Pro Pro Ala Val Lys Ala Gly Gly Met Arg Ile Ser Lys Lys Gln Glu 
            20                  25                  30          


Ile Gly Thr Leu Glu Arg His Thr Lys Lys Thr Gly Phe Glu Lys Thr 
        35                  40                  45              


Ser Ala Ile Ala Asn Val Ala Lys Ile Gln Thr Leu Asp Ala Leu Asn 
    50                  55                  60                  


Asp Ala Leu Glu Lys Leu Asn Tyr Lys Phe Pro Ala Thr Val His Met 
65                  70                  75                  80  


Ala His Gln Lys Pro Thr Pro Ala Leu Glu Lys Val Val Pro Leu Lys 
                85                  90                  95      


Arg Ile Tyr Ile Ile Gln Gln Pro Arg Lys Cys 
            100                 105         


<210>  649
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  649

Met Glu Met Ala Ser Ser Ala Gly Ser Trp Leu Ser Gly Cys Leu Ile 
1               5                   10                  15      


Pro Leu Val Phe Leu Arg Leu Ser Val His Val Ser Gly His Ala Gly 
            20                  25                  30          


Asp Ala Gly Lys Phe His Val Ala Leu Leu Gly Gly Thr Ala Glu Leu 
        35                  40                  45              


Leu Cys Pro Leu Ser Leu Trp Pro Gly Thr Val Pro Lys Glu Val Arg 
    50                  55                  60                  


Trp Leu Arg Ser Pro Phe Pro Gln Arg Ser Gln Ala Val His Ile Phe 
65                  70                  75                  80  


Arg Asp Gly Lys Asp Gln Asp Glu Asp Leu Met Pro Glu Tyr Lys Gly 
                85                  90                  95      


Arg Thr Val Leu Val Arg Asp Ala Gln Glu Gly Ser Val Thr Leu Gln 
            100                 105                 110         


Ile Leu Asp Val Arg Leu Glu Asp Gln Gly Ser Tyr Arg Cys Leu Ile 
        115                 120                 125             


Gln Val Gly Asn Leu Ser Lys Glu Asp Thr Val Ile Leu Gln Val Ala 
    130                 135                 140                 


Ala Pro Ser Val Gly Ser Leu Ser Pro Ser Ala Val Ala Leu Ala Val 
145                 150                 155                 160 


Ile Leu Pro Val Leu Val Leu Leu Ile Met Val Cys Leu Cys Leu Ile 
                165                 170                 175     


Trp Lys Gln Arg Arg Ala Lys Glu Lys Leu Leu Tyr Glu His Val Thr 
            180                 185                 190         


Glu Val Asp Asn Leu Leu Ser Asp His Ala Lys Glu Lys Gly Lys Leu 
        195                 200                 205             


His Lys Ala Val Lys Lys Leu Arg Ser Glu Leu Lys Leu Lys Arg Ala 
    210                 215                 220                 


Ala Ala Asn Ser Gly Trp Arg Arg Ala Arg Leu His Phe Val Ala Val 
225                 230                 235                 240 


Thr Leu Asp Pro Asp Thr Ala His Pro Lys Leu Ile Leu Ser Glu Asp 
                245                 250                 255     


Gln Arg Cys Val Arg Leu Gly Asp Arg Arg Gln Pro Val Pro Asp Asn 
            260                 265                 270         


Pro Gln Arg Phe Asp Phe Val Val Ser Ile Leu Gly Ser Glu Tyr Phe 
        275                 280                 285             


Thr Thr Gly Cys His Tyr Trp Glu Val Tyr Val Gly Asp Lys Thr Lys 
    290                 295                 300                 


Trp Ile Leu Gly Val Cys Ser Glu Ser Val Ser Arg Lys Gly Lys Val 
305                 310                 315                 320 


Thr Ala Ser Pro Ala Asn Gly His Trp Leu Leu Arg Gln Ser Arg Gly 
                325                 330                 335     


Asn Glu Tyr Glu Ala Leu Thr Ser Pro Gln Thr Ser Phe Arg Leu Lys 
            340                 345                 350         


Glu Pro Pro Arg Cys Val Gly Ile Phe Leu Asp Tyr Glu Ala Gly Val 
        355                 360                 365             


Ile Ser Phe Tyr Asn Val Thr Asn Lys Ser His Ile Phe Thr Phe Thr 
    370                 375                 380                 


His Asn Phe Ser Gly Pro Leu Arg Pro Phe Phe Glu Pro Cys Leu His 
385                 390                 395                 400 


Asp Gly Gly Lys Asn Thr Ala Pro Leu Val Ile Cys Ser Glu Leu His 
                405                 410                 415     


Lys Ser Glu Glu Ser Ile Val Pro Arg Pro Glu Gly Lys Gly His Ala 
            420                 425                 430         


Asn Gly Asp Val Ser Leu Lys Val Asn Ser Ser Leu Leu Pro Pro Lys 
        435                 440                 445             


Ala Pro Glu Leu Lys Asp Ile Ile Leu Ser Leu Pro Pro Asp Leu Gly 
    450                 455                 460                 


Pro Ala Leu Gln Glu Leu Lys Ala Pro Ser Phe 
465                 470                 475 


<210>  650
<211>  612
<212>  PRT
<213>  Homo sapiens

<400>  650

Met Ala Ala Glu Thr Leu Leu Ser Ser Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Pro Ala Ser Leu Thr Gly Gly Val Gly Ser Leu Asn 
            20                  25                  30          


Leu Glu Glu Leu Ser Glu Met Arg Tyr Gly Ile Glu Ile Leu Pro Leu 
        35                  40                  45              


Pro Val Met Gly Gly Gln Ser Gln Ser Ser Asp Val Val Ile Val Ser 
    50                  55                  60                  


Ser Lys Tyr Lys Gln Arg Tyr Glu Cys Arg Leu Pro Ala Gly Ala Ile 
65                  70                  75                  80  


His Phe Gln Arg Glu Arg Glu Glu Glu Thr Pro Ala Tyr Gln Gly Pro 
                85                  90                  95      


Gly Ile Pro Glu Leu Leu Ser Pro Met Arg Asp Ala Pro Cys Leu Leu 
            100                 105                 110         


Lys Thr Lys Asp Trp Trp Thr Tyr Glu Phe Cys Tyr Gly Arg His Ile 
        115                 120                 125             


Gln Gln Tyr His Met Glu Asp Ser Glu Ile Lys Gly Glu Val Leu Tyr 
    130                 135                 140                 


Leu Gly Tyr Tyr Gln Ser Ala Phe Asp Trp Asp Asp Glu Thr Ala Lys 
145                 150                 155                 160 


Ala Ser Lys Gln His Arg Leu Lys Arg Tyr His Ser Gln Thr Tyr Gly 
                165                 170                 175     


Asn Gly Ser Lys Cys Asp Leu Asn Gly Arg Pro Arg Glu Ala Glu Val 
            180                 185                 190         


Arg Phe Leu Cys Asp Glu Gly Ala Gly Ile Ser Gly Asp Tyr Ile Asp 
        195                 200                 205             


Arg Val Asp Glu Pro Leu Ser Cys Ser Tyr Val Leu Thr Ile Arg Thr 
    210                 215                 220                 


Pro Arg Leu Cys Pro His Pro Leu Leu Arg Pro Pro Pro Ser Ala Ala 
225                 230                 235                 240 


Pro Gln Ala Ile Leu Cys His Pro Ser Leu Gln Pro Glu Glu Tyr Met 
                245                 250                 255     


Ala Tyr Val Gln Arg Gln Ala Asp Ser Lys Gln Tyr Gly Asp Lys Ile 
            260                 265                 270         


Ile Glu Glu Leu Gln Asp Leu Gly Pro Gln Val Trp Ser Glu Thr Lys 
        275                 280                 285             


Ser Gly Val Ala Pro Gln Lys Met Ala Gly Ala Ser Pro Thr Lys Asp 
    290                 295                 300                 


Asp Ser Lys Asp Ser Asp Phe Trp Lys Met Leu Asn Glu Pro Glu Asp 
305                 310                 315                 320 


Gln Ala Pro Gly Gly Glu Glu Val Pro Ala Glu Glu Gln Asp Pro Ser 
                325                 330                 335     


Pro Glu Ala Ala Asp Ser Ala Ser Gly Ala Pro Asn Asp Phe Gln Asn 
            340                 345                 350         


Asn Val Gln Val Lys Val Ile Arg Ser Pro Ala Asp Leu Ile Arg Phe 
        355                 360                 365             


Ile Glu Glu Leu Lys Gly Gly Thr Lys Lys Gly Lys Pro Asn Ile Gly 
    370                 375                 380                 


Gln Glu Gln Pro Val Asp Asp Ala Ala Glu Val Pro Gln Arg Glu Pro 
385                 390                 395                 400 


Glu Lys Glu Arg Gly Asp Pro Glu Arg Gln Arg Glu Met Glu Glu Glu 
                405                 410                 415     


Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Arg Gln Leu 
            420                 425                 430         


Leu Gly Glu Phe Glu Lys Glu Leu Glu Gly Ile Leu Leu Pro Ser Asp 
        435                 440                 445             


Arg Asp Arg Leu Arg Ser Glu Val Lys Ala Gly Met Glu Arg Glu Leu 
    450                 455                 460                 


Glu Asn Ile Ile Gln Glu Thr Glu Lys Glu Leu Asp Pro Asp Gly Leu 
465                 470                 475                 480 


Lys Lys Glu Ser Glu Arg Asp Arg Ala Met Leu Ala Leu Thr Ser Thr 
                485                 490                 495     


Leu Asn Lys Leu Ile Lys Arg Leu Glu Glu Lys Gln Ser Pro Glu Leu 
            500                 505                 510         


Val Lys Lys His Lys Lys Lys Arg Val Val Pro Lys Lys Pro Pro Pro 
        515                 520                 525             


Ser Pro Gln Pro Thr Gly Lys Ile Glu Ile Lys Ile Val Arg Pro Trp 
    530                 535                 540                 


Ala Glu Gly Thr Glu Glu Gly Ala Arg Trp Leu Thr Asp Glu Asp Thr 
545                 550                 555                 560 


Arg Asn Leu Lys Glu Ile Phe Phe Asn Ile Leu Val Pro Gly Ala Glu 
                565                 570                 575     


Glu Ala Gln Lys Glu Arg Gln Arg Gln Lys Glu Leu Glu Ser Asn Tyr 
            580                 585                 590         


Arg Arg Val Trp Gly Ser Pro Gly Gly Glu Gly Thr Gly Asp Leu Asp 
        595                 600                 605             


Glu Phe Asp Phe 
    610         


<210>  651
<211>  597
<212>  PRT
<213>  Homo sapiens

<400>  651

Met Ala Ala Glu Thr Leu Leu Ser Ser Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Pro Ala Ser Leu Thr Gly Gly Val Gly Ser Leu Asn 
            20                  25                  30          


Leu Glu Glu Leu Ser Glu Met Arg Tyr Gly Ile Glu Ile Leu Pro Leu 
        35                  40                  45              


Pro Val Met Gly Gly Gln Ser Gln Ser Ser Asp Val Val Ile Val Ser 
    50                  55                  60                  


Ser Lys Tyr Lys Gln Arg Tyr Glu Cys Arg Leu Pro Ala Gly Ala Ile 
65                  70                  75                  80  


His Phe Gln Arg Glu Arg Glu Glu Glu Thr Pro Ala Tyr Gln Gly Pro 
                85                  90                  95      


Gly Ile Pro Glu Leu Leu Ser Pro Met Arg Asp Ala Pro Cys Leu Leu 
            100                 105                 110         


Lys Thr Lys Asp Trp Trp Thr Tyr Glu Phe Cys Tyr Gly Arg His Ile 
        115                 120                 125             


Gln Gln Tyr His Met Glu Asp Ser Glu Ile Lys Gly Glu Val Leu Tyr 
    130                 135                 140                 


Leu Gly Tyr Tyr Gln Ser Ala Phe Asp Trp Asp Asp Glu Thr Ala Lys 
145                 150                 155                 160 


Ala Ser Lys Gln His Arg Leu Lys Arg Tyr His Ser Gln Thr Tyr Gly 
                165                 170                 175     


Asn Gly Ser Lys Cys Asp Leu Asn Gly Arg Pro Arg Glu Ala Glu Val 
            180                 185                 190         


Arg Phe Leu Cys Asp Glu Gly Ala Gly Ile Ser Gly Asp Tyr Ile Asp 
        195                 200                 205             


Arg Val Asp Glu Pro Leu Ser Cys Ser Tyr Val Leu Thr Ile Arg Thr 
    210                 215                 220                 


Pro Arg Leu Cys Pro His Pro Leu Leu Arg Pro Pro Pro Ser Ala Ala 
225                 230                 235                 240 


Pro Gln Ala Ile Leu Cys His Pro Ser Leu Gln Pro Glu Glu Tyr Met 
                245                 250                 255     


Ala Tyr Val Gln Arg Gln Ala Asp Ser Lys Gln Tyr Gly Asp Lys Ile 
            260                 265                 270         


Ile Glu Glu Leu Gln Asp Leu Gly Pro Gln Val Trp Ser Glu Thr Lys 
        275                 280                 285             


Ser Gly Val Ala Pro Gln Lys Met Ala Gly Ala Ser Pro Thr Lys Asp 
    290                 295                 300                 


Asp Ser Lys Asp Ser Asp Phe Trp Lys Met Leu Asn Glu Pro Glu Asp 
305                 310                 315                 320 


Gln Ala Pro Gly Gly Glu Glu Val Pro Ala Glu Glu Gln Asp Pro Ser 
                325                 330                 335     


Pro Glu Ala Ala Asp Ser Ala Ser Gly Ala Pro Asn Asp Phe Gln Asn 
            340                 345                 350         


Asn Val Gln Val Lys Val Ile Arg Ser Pro Ala Asp Leu Ile Arg Phe 
        355                 360                 365             


Ile Glu Glu Leu Lys Gly Gly Thr Lys Lys Gly Lys Pro Asn Ile Gly 
    370                 375                 380                 


Gln Glu Gln Pro Val Asp Asp Ala Ala Glu Val Pro Gln Arg Glu Pro 
385                 390                 395                 400 


Glu Lys Glu Arg Gly Asp Pro Glu Arg Gln Arg Glu Met Glu Glu Glu 
                405                 410                 415     


Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Arg Gln Leu 
            420                 425                 430         


Leu Gly Glu Phe Glu Lys Glu Leu Glu Gly Ile Leu Leu Pro Ser Asp 
        435                 440                 445             


Arg Asp Arg Leu Arg Ser Glu Thr Glu Lys Glu Leu Asp Pro Asp Gly 
    450                 455                 460                 


Leu Lys Lys Glu Ser Glu Arg Asp Arg Ala Met Leu Ala Leu Thr Ser 
465                 470                 475                 480 


Thr Leu Asn Lys Leu Ile Lys Arg Leu Glu Glu Lys Gln Ser Pro Glu 
                485                 490                 495     


Leu Val Lys Lys His Lys Lys Lys Arg Val Val Pro Lys Lys Pro Pro 
            500                 505                 510         


Pro Ser Pro Gln Pro Thr Gly Lys Ile Glu Ile Lys Ile Val Arg Pro 
        515                 520                 525             


Trp Ala Glu Gly Thr Glu Glu Gly Ala Arg Trp Leu Thr Asp Glu Asp 
    530                 535                 540                 


Thr Arg Asn Leu Lys Glu Ile Phe Phe Asn Ile Leu Val Pro Gly Ala 
545                 550                 555                 560 


Glu Glu Ala Gln Lys Glu Arg Gln Arg Gln Lys Glu Leu Glu Ser Asn 
                565                 570                 575     


Tyr Arg Arg Val Trp Gly Ser Pro Gly Gly Glu Gly Thr Gly Asp Leu 
            580                 585                 590         


Asp Glu Phe Asp Phe 
        595         


<210>  652
<211>  652
<212>  PRT
<213>  Homo sapiens

<400>  652

Met Ala Ala Glu Thr Leu Leu Ser Ser Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Pro Ala Ser Leu Thr Gly Gly Val Gly Ser Leu Asn 
            20                  25                  30          


Leu Glu Glu Leu Ser Glu Met Arg Tyr Gly Ile Glu Ile Leu Pro Leu 
        35                  40                  45              


Pro Val Met Gly Gly Gln Ser Gln Ser Ser Asp Val Val Ile Val Ser 
    50                  55                  60                  


Ser Lys Tyr Lys Gln Arg Tyr Glu Cys Arg Leu Pro Ala Gly Ala Ile 
65                  70                  75                  80  


His Phe Gln Arg Glu Arg Glu Glu Glu Thr Pro Ala Tyr Gln Gly Pro 
                85                  90                  95      


Gly Ile Pro Glu Leu Leu Ser Pro Met Arg Asp Ala Pro Cys Leu Leu 
            100                 105                 110         


Lys Thr Lys Asp Trp Trp Thr Tyr Glu Phe Cys Tyr Gly Arg His Ile 
        115                 120                 125             


Gln Gln Tyr His Met Glu Asp Ser Glu Ile Lys Gly Glu Val Leu Tyr 
    130                 135                 140                 


Leu Gly Tyr Tyr Gln Ser Ala Phe Asp Trp Asp Asp Glu Thr Ala Lys 
145                 150                 155                 160 


Ala Ser Lys Gln His Arg Leu Lys Arg Tyr His Ser Gln Thr Tyr Gly 
                165                 170                 175     


Asn Gly Ser Lys Cys Asp Leu Asn Gly Arg Pro Arg Glu Ala Glu Val 
            180                 185                 190         


Arg Phe Leu Cys Asp Glu Gly Ala Gly Ile Ser Gly Asp Tyr Ile Asp 
        195                 200                 205             


Arg Val Asp Glu Pro Leu Ser Cys Ser Tyr Val Leu Thr Ile Arg Thr 
    210                 215                 220                 


Pro Arg Leu Cys Pro His Pro Leu Leu Arg Pro Pro Pro Ser Ala Ala 
225                 230                 235                 240 


Pro Gln Ala Ile Leu Cys His Pro Ser Leu Gln Pro Glu Glu Tyr Met 
                245                 250                 255     


Ala Tyr Val Gln Arg Gln Ala Asp Ser Lys Gln Tyr Gly Asp Lys Ile 
            260                 265                 270         


Ile Glu Glu Leu Gln Asp Leu Gly Pro Gln Val Trp Ser Glu Thr Lys 
        275                 280                 285             


Ser Gly Val Ala Pro Gln Lys Met Ala Gly Ala Ser Pro Thr Lys Asp 
    290                 295                 300                 


Asp Ser Lys Asp Ser Asp Phe Trp Lys Met Leu Asn Glu Pro Glu Asp 
305                 310                 315                 320 


Gln Ala Pro Gly Gly Glu Glu Val Pro Ala Glu Glu Gln Asp Pro Ser 
                325                 330                 335     


Pro Glu Ala Ala Asp Ser Ala Ser Gly Ala Pro Asn Asp Phe Gln Asn 
            340                 345                 350         


Asn Val Gln Val Lys Val Ile Arg Ser Pro Ala Asp Leu Ile Arg Phe 
        355                 360                 365             


Ile Glu Glu Leu Lys Gly Gly Thr Lys Lys Gly Lys Pro Asn Ile Gly 
    370                 375                 380                 


Gln Glu Gln Pro Val Asp Asp Ala Ala Glu Val Pro Gln Arg Glu Pro 
385                 390                 395                 400 


Glu Lys Glu Arg Gly Asp Pro Glu Arg Gln Arg Glu Met Glu Glu Glu 
                405                 410                 415     


Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Arg Gln Leu 
            420                 425                 430         


Leu Gly Glu Phe Glu Lys Glu Leu Glu Gly Ile Leu Leu Pro Ser Asp 
        435                 440                 445             


Arg Asp Arg Leu Arg Ser Glu Thr Glu Lys Glu Leu Asp Pro Asp Gly 
    450                 455                 460                 


Leu Lys Lys Glu Ser Glu Arg Asp Arg Ala Met Leu Ala Leu Thr Ser 
465                 470                 475                 480 


Thr Leu Asn Lys Leu Ile Lys Arg Leu Glu Glu Lys Gln Ser Pro Glu 
                485                 490                 495     


Leu Val Lys Lys His Lys Lys Lys Arg Val Val Pro Lys Lys Pro Pro 
            500                 505                 510         


Pro Ser Pro Gln Pro Thr Glu Glu Asp Pro Glu His Arg Val Arg Val 
        515                 520                 525             


Arg Val Thr Lys Leu Arg Leu Gly Gly Pro Asn Gln Asp Leu Thr Val 
    530                 535                 540                 


Leu Glu Met Lys Arg Glu Asn Pro Gln Leu Lys Gln Ile Glu Gly Leu 
545                 550                 555                 560 


Val Lys Glu Leu Leu Glu Arg Glu Gly Leu Thr Ala Ala Gly Lys Ile 
                565                 570                 575     


Glu Ile Lys Ile Val Arg Pro Trp Ala Glu Gly Thr Glu Glu Gly Ala 
            580                 585                 590         


Arg Trp Leu Thr Asp Glu Asp Thr Arg Asn Leu Lys Glu Ile Phe Phe 
        595                 600                 605             


Asn Ile Leu Val Pro Gly Ala Glu Glu Ala Gln Lys Glu Arg Gln Arg 
    610                 615                 620                 


Gln Lys Glu Leu Glu Ser Asn Tyr Arg Arg Val Trp Gly Ser Pro Gly 
625                 630                 635                 640 


Gly Glu Gly Thr Gly Asp Leu Asp Glu Phe Asp Phe 
                645                 650         


<210>  653
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  653

Met Glu Asp Pro Ser Gly Ala Arg Glu Pro Arg Ala Arg Pro Arg Glu 
1               5                   10                  15      


Arg Asp Pro Gly Arg Arg Pro His Pro Asp Gln Gly Arg Thr His Asp 
            20                  25                  30          


Arg Pro Arg Asp Arg Pro Gly Asp Pro Arg Arg Lys Arg Ser Ser Asp 
        35                  40                  45              


Gly Asn Arg Arg Arg Asp Gly Asp Arg Asp Pro Glu Arg Asp Gln Glu 
    50                  55                  60                  


Arg Asp Gly Asn Arg Asp Arg Asn Arg Asp Arg Glu Arg Glu Arg Glu 
65                  70                  75                  80  


Arg Glu Arg Asp Pro Asp Arg Gly Pro Arg Arg Asp Thr His Arg Asp 
                85                  90                  95      


Ala Gly Pro Arg Ala Gly Glu His Gly Val Trp Glu Lys Pro Arg Gln 
            100                 105                 110         


Ser Arg Thr Arg Asp Gly Ala Arg Gly Leu Thr Trp Asp Ala Ala Ala 
        115                 120                 125             


Pro Pro Gly Pro Ala Pro Trp Glu Ala Pro Glu Pro Pro Gln Pro Gln 
    130                 135                 140                 


Arg Lys Gly Asp Pro Gly Arg Arg Arg Pro Glu Ser Glu Pro Pro Ser 
145                 150                 155                 160 


Glu Arg Tyr Leu Pro Ser Thr Pro Arg Pro Gly Arg Glu Glu Val Glu 
                165                 170                 175     


Tyr Tyr Gln Ser Glu Ala Glu Gly Leu Leu Glu Cys His Lys Cys Lys 
            180                 185                 190         


Tyr Leu Cys Thr Gly Arg Gly Val Val Gln Ile Val Glu Val Val Leu 
        195                 200                 205             


Asn Gly Met Val Leu Ile Cys Ile Val Ala Ser Tyr Phe Val Leu Ala 
    210                 215                 220                 


Gly Phe Ser Ala Ser Phe Ser Ser Gly Gly Gly Phe Gly Asn Asn Tyr 
225                 230                 235                 240 


Tyr Ser Pro Phe Glu Gly Thr Glu Leu Glu Gln Val Arg Gln Leu Asp 
                245                 250                 255     


Gln Gln Tyr Thr Ile Leu Arg Ser Pro Leu Ile Tyr Gly Gly Val Ala 
            260                 265                 270         


Val Ser Leu Gly Leu Gly Val Leu Thr Met Gly Val Leu Leu Gln Gly 
        275                 280                 285             


Ala Lys Ser Arg Thr Met Leu Ser Gly Lys Trp Leu Leu Thr Glu Ala 
    290                 295                 300                 


Ala Phe Ser Leu Leu Ala Ala Val Gly Tyr Cys Thr Gly Ile Gly Val 
305                 310                 315                 320 


Tyr Leu His Val Ala Leu Gln Ile Asn Ser Thr Asp Thr Cys Lys Thr 
                325                 330                 335     


Arg Glu Arg Leu Tyr Ala Arg Lys Gly Leu Thr Trp Met Asp Cys Gln 
            340                 345                 350         


Leu Ala Gly Thr Asp Gly Ala Ala Ala Thr Phe Ala Cys Leu Leu Val 
        355                 360                 365             


Ile Met Tyr Gly Ala Ser Val Val Leu Ala Leu Arg Ser Tyr Arg Glu 
    370                 375                 380                 


Gln Lys Arg Tyr Lys Gly Ser Arg Glu Gln Pro Gly Ser Tyr Ser Asp 
385                 390                 395                 400 


Ala Pro Glu Tyr Leu Trp Ser Gly Thr Leu 
                405                 410 


<210>  654
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  654

Met Thr Trp Ser Ala Thr Ala Arg Gly Ala His Gln Pro Asp Asn Thr 
1               5                   10                  15      


Ala Phe Thr Gln Gln Arg Leu Pro Ala Trp Gln Pro Leu Leu Ser Ala 
            20                  25                  30          


Ser Ile Ala Leu Pro Leu Phe Phe Cys Ala Gly Leu Ala Phe Ile Gly 
        35                  40                  45              


Leu Gly Leu Gly Leu Tyr Tyr Ser Ser Asn Gly Ile Lys Glu Leu Glu 
    50                  55                  60                  


Tyr Asp Tyr Thr Gly Asp Pro Gly Thr Gly Asn Cys Ser Val Cys Ala 
65                  70                  75                  80  


Ala Ala Gly Gln Gly Arg Ala Leu Pro Pro Pro Cys Ser Cys Ala Trp 
                85                  90                  95      


Tyr Phe Ser Leu Pro Glu Leu Phe Gln Gly Pro Val Tyr Leu Tyr Tyr 
            100                 105                 110         


Glu Leu Thr Asn Phe Tyr Gln Asn Asn Arg Arg Tyr Gly Val Ser Arg 
        115                 120                 125             


Asp Asp Ala Gln Leu Ser Gly Leu Pro Ser Ala Leu Arg His Pro Val 
    130                 135                 140                 


Asn Glu Cys Ala Pro Tyr Gln Arg Ser Ala Ala Gly Leu Pro Ile Ala 
145                 150                 155                 160 


Pro Cys Gly Ala Ile Ala Asn Ser Leu Phe Asn Asp Ser Phe Ser Leu 
                165                 170                 175     


Trp His Gln Arg Gln Pro Gly Gly Pro Tyr Val Glu Val Pro Leu Asp 
            180                 185                 190         


Arg Ser Gly Ile Ala Trp Trp Thr Asp Tyr His Val Lys Phe Arg Asn 
        195                 200                 205             


Pro Pro Leu Val Asn Gly Ser Leu Ala Leu Ala Phe Gln Gly Thr Ala 
    210                 215                 220                 


Pro Pro Pro Asn Trp Arg Arg Pro Val Tyr Glu Leu Ser Pro Asp Pro 
225                 230                 235                 240 


Asn Asn Thr Gly Phe Ile Asn Gln Asp Phe Val Val Trp Met Arg Thr 
                245                 250                 255     


Ala Ala Leu Pro Thr Phe Arg Lys Leu Tyr Ala Arg Ile Arg Gln Gly 
            260                 265                 270         


Asn Tyr Ser Ala Gly Leu Pro Arg Gly Ala Tyr Arg Val Asn Ile Thr 
        275                 280                 285             


Tyr Asn Tyr Pro Val Arg Ala Phe Gly Gly His Lys Leu Leu Ile Phe 
    290                 295                 300                 


Ser Ser Ile Ser Trp Met Gly Gly Lys Asn Pro Phe Leu Gly Ile Ala 
305                 310                 315                 320 


Tyr Leu Val Val Gly Ser Leu Cys Ile Leu Thr Gly Phe Val Met Leu 
                325                 330                 335     


Val Val Tyr Ile Arg Tyr Gln Asp Gln Asp Asp Asp Asp Glu Glu 
            340                 345                 350     


<210>  655
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  655

Met Arg Leu Trp Lys Ala Arg Val Leu Lys Leu Val Leu Lys Thr Ala 
1               5                   10                  15      


Lys Asp Ser Arg Leu Gly Leu Asn Ser Lys Trp Leu Ser Leu Lys Leu 
            20                  25                  30          


Gly Asp Ala Gly Asn Pro Arg Ser Leu Ala Ile Arg Phe Ile Leu Thr 
        35                  40                  45              


Asn Tyr Asn Lys Leu Ser Ile Gln Ser Trp Phe Ser Leu Arg Arg Val 
    50                  55                  60                  


Glu Ile Ile Ser Asn Asn Ser Ile Gln Ala Val Phe Asn Pro Thr Gly 
65                  70                  75                  80  


Val Tyr Ala Pro Ser Gly Tyr Ser Tyr Arg Cys Gln Arg Val Gly Ser 
                85                  90                  95      


Leu Gln Gln Asp Gln Ala Leu Leu Leu Pro Ser Asp Thr Asp Asp Gly 
            100                 105                 110         


Ser Ser Leu Trp Glu Val Thr Phe Ile Asp Phe Gln Ile Gln Gly Phe 
        115                 120                 125             


Ala Ile Lys Gly Gly Arg Phe Thr Lys Ala Gln Asp Cys Ala Ser Ser 
    130                 135                 140                 


Phe Ser Pro Ala Phe Leu Ile Gly Leu Ala Met Ser Leu Ile Leu Leu 
145                 150                 155                 160 


Leu Val Leu Ala Tyr Ala Leu His Met Leu Ile Tyr Leu Arg Tyr Leu 
                165                 170                 175     


Asp Gln Gln Tyr Asp Leu Ile Ala Ser Pro Ala His Phe Ser Gln Leu 
            180                 185                 190         


Lys Ala Arg Asp Thr Ala Glu Glu Lys Glu Leu Leu Arg Ser Gln Gly 
        195                 200                 205             


Ala Glu Cys Tyr Lys Leu Arg Ser Gln Gln Ile Ser Lys Ile Tyr Val 
    210                 215                 220                 


<210>  656
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  656

Met Lys Leu Trp Val Ser Ala Leu Leu Met Ala Trp Phe Gly Val Leu 
1               5                   10                  15      


Ser Cys Val Gln Ala Glu Phe Phe Thr Ser Ile Gly His Met Thr Asp 
            20                  25                  30          


Leu Ile Tyr Ala Glu Lys Glu Leu Val Gln Ser Leu Lys Glu Tyr Ile 
        35                  40                  45              


Leu Val Glu Glu Ala Lys Leu Ser Lys Ile Lys Ser Trp Ala Asn Lys 
    50                  55                  60                  


Met Glu Ala Leu Thr Ser Lys Ser Ala Ala Asp Ala Glu Gly Tyr Leu 
65                  70                  75                  80  


Ala His Pro Val Asn Ala Tyr Lys Leu Val Lys Arg Leu Asn Thr Asp 
                85                  90                  95      


Trp Pro Ala Leu Glu Asp Leu Val Leu Gln Asp Ser Ala Ala Gly Phe 
            100                 105                 110         


Ile Ala Asn Leu Ser Val Gln Arg Gln Phe Phe Pro Thr Asp Glu Asp 
        115                 120                 125             


Glu Ile Gly Ala Ala Lys Ala Leu Met Arg Leu Gln Asp Thr Tyr Arg 
    130                 135                 140                 


Leu Asp Pro Gly Thr Ile Ser Arg Gly Glu Leu Pro Gly Thr Lys Tyr 
145                 150                 155                 160 


Gln Ala Met Leu Ser Val Asp Asp Cys Phe Gly Met Gly Arg Ser Ala 
                165                 170                 175     


Tyr Asn Glu Gly Asp Tyr Tyr His Thr Val Leu Trp Met Glu Gln Val 
            180                 185                 190         


Leu Lys Gln Leu Asp Ala Gly Glu Glu Ala Thr Thr Thr Lys Ser Gln 
        195                 200                 205             


Val Leu Asp Tyr Leu Ser Tyr Ala Val Phe Gln Leu Gly Asp Leu His 
    210                 215                 220                 


Arg Ala Leu Glu Leu Thr Arg Arg Leu Leu Ser Leu Asp Pro Ser His 
225                 230                 235                 240 


Glu Arg Ala Gly Gly Asn Leu Arg Tyr Phe Glu Gln Leu Leu Glu Glu 
                245                 250                 255     


Glu Arg Glu Lys Thr Leu Thr Asn Gln Thr Glu Ala Glu Leu Ala Thr 
            260                 265                 270         


Pro Glu Gly Ile Tyr Glu Arg Pro Val Asp Tyr Leu Pro Glu Arg Asp 
        275                 280                 285             


Val Tyr Glu Ser Leu Cys Arg Gly Glu Gly Val Lys Leu Thr Pro Arg 
    290                 295                 300                 


Arg Gln Lys Arg Leu Phe Cys Arg Tyr His His Gly Asn Arg Ala Pro 
305                 310                 315                 320 


Gln Leu Leu Ile Ala Pro Phe Lys Glu Glu Asp Glu Trp Asp Ser Pro 
                325                 330                 335     


His Ile Val Arg Tyr Tyr Asp Val Met Ser Asp Glu Glu Ile Glu Arg 
            340                 345                 350         


Ile Lys Glu Ile Ala Lys Pro Lys Leu Ala Arg Ala Thr Val Arg Asp 
        355                 360                 365             


Pro Lys Thr Gly Val Leu Thr Val Ala Ser Tyr Arg Val Ser Lys Ser 
    370                 375                 380                 


Ser Trp Leu Glu Glu Asp Asp Asp Pro Val Val Ala Arg Val Asn Arg 
385                 390                 395                 400 


Arg Met Gln His Ile Thr Gly Leu Thr Val Lys Thr Ala Glu Leu Leu 
                405                 410                 415     


Gln Val Ala Asn Tyr Gly Val Gly Gly Gln Tyr Glu Pro His Phe Asp 
            420                 425                 430         


Phe Ser Arg Arg Pro Phe Asp Ser Gly Leu Lys Thr Glu Gly Asn Arg 
        435                 440                 445             


Leu Ala Thr Phe Leu Asn Tyr Met Ser Asp Val Glu Ala Gly Gly Ala 
    450                 455                 460                 


Thr Val Phe Pro Asp Leu Gly Ala Ala Ile Trp Pro Lys Lys Gly Thr 
465                 470                 475                 480 


Ala Val Phe Trp Tyr Asn Leu Leu Arg Ser Gly Glu Gly Asp Tyr Arg 
                485                 490                 495     


Thr Arg His Ala Ala Cys Pro Val Leu Val Gly Cys Lys Trp Val Ser 
            500                 505                 510         


Asn Lys Trp Phe His Glu Arg Gly Gln Glu Phe Leu Arg Pro Cys Gly 
        515                 520                 525             


Ser Thr Glu Val Asp 
    530             


<210>  657
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  657

Met Lys Leu Trp Val Ser Ala Leu Leu Met Ala Trp Phe Gly Val Leu 
1               5                   10                  15      


Ser Cys Val Gln Ala Glu Phe Phe Thr Ser Ile Gly His Met Thr Asp 
            20                  25                  30          


Leu Ile Tyr Ala Glu Lys Glu Leu Val Gln Ser Leu Lys Glu Tyr Ile 
        35                  40                  45              


Leu Val Glu Glu Ala Lys Leu Ser Lys Ile Lys Ser Trp Ala Asn Lys 
    50                  55                  60                  


Met Glu Ala Leu Thr Ser Lys Ser Ala Ala Asp Ala Glu Gly Tyr Leu 
65                  70                  75                  80  


Ala His Pro Val Asn Ala Tyr Lys Leu Val Lys Arg Leu Asn Thr Asp 
                85                  90                  95      


Trp Pro Ala Leu Glu Asp Leu Val Leu Gln Asp Ser Ala Ala Gly Phe 
            100                 105                 110         


Ile Ala Asn Leu Ser Val Gln Arg Gln Phe Phe Pro Thr Asp Glu Asp 
        115                 120                 125             


Glu Ile Gly Ala Ala Lys Ala Leu Met Arg Leu Gln Asp Thr Tyr Arg 
    130                 135                 140                 


Leu Asp Pro Gly Thr Ile Ser Arg Gly Glu Leu Pro Gly Thr Lys Tyr 
145                 150                 155                 160 


Gln Ala Met Leu Ser Val Asp Asp Cys Phe Gly Met Gly Arg Ser Ala 
                165                 170                 175     


Tyr Asn Glu Gly Asp Tyr Tyr His Thr Val Leu Trp Met Glu Gln Val 
            180                 185                 190         


Leu Lys Gln Leu Asp Ala Gly Glu Glu Ala Thr Thr Thr Lys Ser Gln 
        195                 200                 205             


Val Leu Asp Tyr Leu Ser Tyr Ala Val Phe Gln Leu Gly Asp Leu His 
    210                 215                 220                 


Arg Ala Leu Glu Leu Thr Arg Arg Leu Leu Ser Leu Asp Pro Ser His 
225                 230                 235                 240 


Glu Arg Ala Gly Gly Asn Leu Arg Tyr Phe Glu Gln Leu Leu Glu Glu 
                245                 250                 255     


Glu Arg Glu Lys Thr Leu Thr Asn Gln Thr Glu Ala Glu Leu Ala Thr 
            260                 265                 270         


Pro Glu Gly Ile Tyr Glu Arg Pro Val Asp Tyr Leu Pro Glu Arg Asp 
        275                 280                 285             


Val Tyr Glu Ser Leu Cys Arg Gly Glu Gly Val Lys Leu Thr Pro Arg 
    290                 295                 300                 


Arg Gln Lys Arg Leu Phe Cys Arg Tyr His His Gly Asn Arg Ala Pro 
305                 310                 315                 320 


Gln Leu Leu Ile Ala Pro Phe Lys Glu Glu Asp Glu Trp Asp Ser Pro 
                325                 330                 335     


His Ile Val Arg Tyr Tyr Asp Val Met Ser Asp Glu Glu Ile Glu Arg 
            340                 345                 350         


Ile Lys Glu Ile Ala Lys Pro Lys Leu Ala Arg Ala Thr Val Arg Asp 
        355                 360                 365             


Pro Lys Thr Gly Val Leu Thr Val Ala Ser Tyr Arg Val Ser Lys Ser 
    370                 375                 380                 


Ser Trp Leu Glu Glu Asp Asp Asp Pro Val Val Ala Arg Val Asn Arg 
385                 390                 395                 400 


Arg Met Gln His Ile Thr Gly Leu Thr Val Lys Thr Ala Glu Leu Leu 
                405                 410                 415     


Gln Val Ala Asn Tyr Gly Val Gly Gly Gln Tyr Glu Pro His Phe Asp 
            420                 425                 430         


Phe Ser Arg Arg Pro Phe Asp Ser Gly Leu Lys Thr Glu Gly Asn Arg 
        435                 440                 445             


Leu Ala Thr Phe Leu Asn Tyr Met Ser Asp Val Glu Ala Gly Gly Ala 
    450                 455                 460                 


Thr Val Phe Pro Asp Leu Gly Ala Ala Ile Trp Pro Lys Lys Gly Thr 
465                 470                 475                 480 


Ala Val Phe Trp Tyr Asn Leu Leu Arg Ser Gly Glu Gly Asp Tyr Arg 
                485                 490                 495     


Thr Arg His Ala Ala Cys Pro Val Leu Val Gly Cys Lys Trp Val Ser 
            500                 505                 510         


Asn Lys Trp Phe His Glu Arg Gly Gln Glu Phe Leu Arg Pro Cys Gly 
        515                 520                 525             


Ser Thr Glu Val Asp 
    530             


<210>  658
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  658

Met Asn Phe Tyr Leu Leu Leu Ala Ser Ser Ile Leu Cys Ala Leu Ile 
1               5                   10                  15      


Val Phe Trp Lys Tyr Arg Arg Phe Gln Arg Asn Thr Gly Glu Met Ser 
            20                  25                  30          


Ser Asn Ser Thr Ala Leu Ala Leu Val Arg Pro Ser Ser Ser Gly Leu 
        35                  40                  45              


Ile Asn Ser Asn Thr Asp Asn Asn Leu Ala Val Tyr Asp Leu Ser Arg 
    50                  55                  60                  


Asp Ile Leu Asn Asn Phe Pro His Ser Ile Ala Arg Gln Lys Arg Ile 
65                  70                  75                  80  


Leu Val Asn Leu Ser Met Val Glu Asn Lys Leu Val Glu Leu Glu His 
                85                  90                  95      


Thr Leu Leu Ser Lys Gly Phe Arg Gly Ala Ser Pro His Arg Lys Ser 
            100                 105                 110         


Thr 
    


<210>  659
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  659

Met Glu Arg Pro Asp Lys Ala Ala Leu Asn Ala Leu Gln Pro Pro Glu 
1               5                   10                  15      


Phe Arg Asn Glu Ser Ser Leu Ala Ser Thr Leu Lys Thr Leu Leu Phe 
            20                  25                  30          


Phe Thr Ala Leu Met Ile Thr Val Pro Ile Gly Leu Tyr Phe Thr Thr 
        35                  40                  45              


Lys Ser Tyr Ile Phe Glu Gly Ala Leu Gly Met Ser Asn Arg Asp Ser 
    50                  55                  60                  


Tyr Phe Tyr Ala Ala Ile Val Ala Val Val Ala Val His Val Val Leu 
65                  70                  75                  80  


Ala Leu Phe Val Tyr Val Ala Trp Asn Glu Gly Ser Arg Gln Trp Arg 
                85                  90                  95      


Glu Gly Lys Gln Asp 
            100     


<210>  660
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  660

Met Ser Ser Gly Ala Ser Ala Ser Ala Leu Gln Arg Leu Val Glu Gln 
1               5                   10                  15      


Leu Lys Leu Glu Ala Gly Val Glu Arg Ile Lys Val Ser Gln Ala Ala 
            20                  25                  30          


Ala Glu Leu Gln Gln Tyr Cys Met Gln Asn Ala Cys Lys Asp Ala Leu 
        35                  40                  45              


Leu Val Gly Val Pro Ala Gly Ser Asn Pro Phe Arg Glu Pro Arg Ser 
    50                  55                  60                  


Cys Ala Leu Leu 
65              


<210>  661
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  661

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 
    50                  55                  60                  


Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 
65                  70                  75                  80  


Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu 
                85                  90                  95      


Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu 
            100                 105                 110         


Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr 
        115                 120                 125             


Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr 
    130                 135                 140                 


Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln 
145                 150                 155                 160 


Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val 
                165                 170                 175     


Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val 
            180                 185                 190         


Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala 
        195                 200                 205             


Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His 
    210                 215                 220                 


Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys 
225                 230                 235                 240 


Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala 
                245                 250                 255     


Val Ala Ala Thr Ser Ala Asn Leu 
            260                 


<210>  662
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  662

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp 
    50                  55                  60                  


Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu Gln Ile 
65                  70                  75                  80  


Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro 
                85                  90                  95      


Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile 
            100                 105                 110         


Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala 
        115                 120                 125             


Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val 
    130                 135                 140                 


Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly 
145                 150                 155                 160 


Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val 
                165                 170                 175     


Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly 
            180                 185                 190         


Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu 
        195                 200                 205             


Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr 
    210                 215                 220                 


Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser 
225                 230                 235                 240 


Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
                245                 250                 255 


<210>  663
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  663

Met Arg Pro Ala Asp Leu Leu Gln Leu Val Leu Leu Leu Asp Leu Pro 
1               5                   10                  15      


Arg Asp Leu Gly Gly Met Gly Cys Ser Ser Pro Pro Cys Glu Cys His 
            20                  25                  30          


Gln Glu Glu Asp Phe Arg Val Thr Cys Lys Asp Ile Gln Arg Ile Pro 
        35                  40                  45              


Ser Leu Pro Pro Ser Thr Gln Thr Leu Lys Leu Ile Glu Thr His Leu 
    50                  55                  60                  


Arg Thr Ile Pro Ser His Ala Phe Ser Asn Leu Pro Asn Ile Ser Arg 
65                  70                  75                  80  


Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu Ser His Ser 
                85                  90                  95      


Phe Tyr Asn Leu Ser Lys Val Thr His Ile Glu Ile Arg Asn Thr Arg 
            100                 105                 110         


Asn Leu Thr Tyr Ile Asp Pro Asp Ala Leu Lys Glu Leu Pro Leu Leu 
        115                 120                 125             


Lys Phe Leu Gly Ile Phe Asn Thr Gly Leu Lys Met Phe Pro Asp Leu 
    130                 135                 140                 


Thr Lys Val Tyr Ser Thr Asp Ile Phe Phe Ile Leu Glu Ile Thr Asp 
145                 150                 155                 160 


Asn Pro Tyr Met Thr Ser Ile Pro Val Asn Ala Phe Gln Gly Leu Cys 
                165                 170                 175     


Asn Glu Thr Leu Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Val 
            180                 185                 190         


Gln Gly Tyr Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu Asn 
        195                 200                 205             


Lys Asn Lys Tyr Leu Thr Val Ile Asp Lys Asp Ala Phe Gly Gly Val 
    210                 215                 220                 


Tyr Ser Gly Pro Ser Leu Leu Leu Pro Leu Gly Arg Lys Ser Leu Ser 
225                 230                 235                 240 


Phe Glu Thr Gln Lys Ala Pro Arg Ser Ser Met Pro Ser 
                245                 250             


<210>  664
<211>  904
<212>  PRT
<213>  Homo sapiens

<400>  664

Met Gly Leu Pro Glu Pro Gly Pro Leu Arg Leu Leu Ala Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Gln Leu Gln His Leu Ala Ala Ala 
            20                  25                  30          


Ala Ala Asp Pro Leu Leu Gly Gly Gln Gly Pro Ala Lys Asp Cys Glu 
        35                  40                  45              


Lys Asp Gln Phe Gln Cys Arg Asn Glu Arg Cys Ile Pro Ser Val Trp 
    50                  55                  60                  


Arg Cys Asp Glu Asp Asp Asp Cys Leu Asp His Ser Asp Glu Asp Asp 
65                  70                  75                  80  


Cys Pro Lys Lys Thr Cys Ala Asp Ser Asp Phe Thr Cys Asp Asn Gly 
                85                  90                  95      


His Cys Ile His Glu Arg Trp Lys Cys Asp Gly Glu Glu Glu Cys Pro 
            100                 105                 110         


Asp Gly Ser Asp Glu Ser Glu Ala Thr Cys Thr Lys Gln Val Cys Pro 
        115                 120                 125             


Ala Glu Lys Leu Ser Cys Gly Pro Thr Ser His Lys Cys Val Pro Ala 
    130                 135                 140                 


Ser Trp Arg Cys Asp Gly Glu Lys Asp Cys Glu Gly Gly Ala Asp Glu 
145                 150                 155                 160 


Ala Gly Cys Ala Thr Leu Cys Ala Pro His Glu Phe Gln Cys Gly Asn 
                165                 170                 175     


Arg Ser Cys Leu Ala Ala Val Phe Val Cys Asp Gly Asp Asp Asp Cys 
            180                 185                 190         


Gly Asp Gly Ser Asp Glu Arg Gly Cys Ala Asp Pro Ala Cys Gly Pro 
        195                 200                 205             


Arg Glu Phe Arg Cys Gly Gly Asp Gly Gly Gly Ala Cys Ile Pro Glu 
    210                 215                 220                 


Arg Trp Val Cys Asp Arg Gln Phe Asp Cys Glu Asp Arg Ser Asp Glu 
225                 230                 235                 240 


Ala Ala Glu Leu Cys Gly Arg Pro Gly Pro Gly Ala Thr Ser Ala Pro 
                245                 250                 255     


Ala Ala Cys Ala Thr Ala Ser Gln Phe Ala Cys Arg Ser Gly Glu Cys 
            260                 265                 270         


Val His Leu Gly Trp Arg Cys Asp Gly Asp Arg Asp Cys Lys Asp Lys 
        275                 280                 285             


Ser Asp Glu Ala Asp Cys Pro Leu Gly Thr Cys Arg Gly Asp Glu Phe 
    290                 295                 300                 


Gln Cys Gly Asp Gly Thr Cys Val Leu Ala Ile Lys His Cys Asn Gln 
305                 310                 315                 320 


Glu Gln Asp Cys Pro Asp Gly Ser Asp Glu Ala Gly Cys Leu Gln Gly 
                325                 330                 335     


Leu Asn Glu Cys Leu His Asn Asn Gly Gly Cys Ser His Ile Cys Thr 
            340                 345                 350         


Asp Leu Lys Ile Gly Phe Glu Cys Thr Cys Pro Ala Gly Phe Gln Leu 
        355                 360                 365             


Leu Asp Gln Lys Thr Cys Gly Asp Ile Asp Glu Cys Lys Asp Pro Asp 
    370                 375                 380                 


Ala Cys Ser Gln Ile Cys Val Asn Tyr Lys Gly Tyr Phe Lys Cys Glu 
385                 390                 395                 400 


Cys Tyr Pro Gly Tyr Glu Met Asp Leu Leu Thr Lys Asn Cys Lys Ala 
                405                 410                 415     


Ala Ala Gly Lys Ser Pro Ser Leu Ile Phe Thr Asn Arg His Glu Val 
            420                 425                 430         


Arg Arg Ile Asp Leu Val Lys Arg Asn Tyr Ser Arg Leu Ile Pro Met 
        435                 440                 445             


Leu Lys Asn Val Val Ala Leu Asp Val Glu Val Ala Thr Asn Arg Ile 
    450                 455                 460                 


Tyr Trp Cys Asp Leu Ser Tyr Arg Lys Ile Tyr Ser Ala Tyr Met Asp 
465                 470                 475                 480 


Lys Ala Ser Asp Pro Lys Glu Gln Glu Val Leu Ile Asp Glu Gln Leu 
                485                 490                 495     


His Ser Pro Glu Gly Leu Ala Val Asp Trp Val His Lys His Ile Tyr 
            500                 505                 510         


Trp Thr Asp Ser Gly Asn Lys Thr Ile Ser Val Ala Thr Val Asp Gly 
        515                 520                 525             


Gly Arg Arg Arg Thr Leu Phe Ser Arg Asn Leu Ser Glu Pro Arg Ala 
    530                 535                 540                 


Ile Ala Val Asp Pro Leu Arg Gly Phe Met Tyr Trp Ser Asp Trp Gly 
545                 550                 555                 560 


Asp Gln Ala Lys Ile Glu Lys Ser Gly Leu Asn Gly Val Asp Arg Gln 
                565                 570                 575     


Thr Leu Val Ser Asp Asn Ile Glu Trp Pro Asn Gly Ile Thr Leu Asp 
            580                 585                 590         


Leu Leu Ser Gln Arg Leu Tyr Trp Val Asp Ser Lys Leu His Gln Leu 
        595                 600                 605             


Ser Ser Ile Asp Phe Ser Gly Gly Asn Arg Lys Thr Leu Ile Ser Ser 
    610                 615                 620                 


Thr Asp Phe Leu Ser His Pro Phe Gly Ile Ala Val Phe Glu Asp Lys 
625                 630                 635                 640 


Val Phe Trp Thr Asp Leu Glu Asn Glu Ala Ile Phe Ser Ala Asn Arg 
                645                 650                 655     


Leu Asn Gly Leu Glu Ile Ser Ile Leu Ala Glu Asn Leu Asn Asn Pro 
            660                 665                 670         


His Asp Ile Val Ile Phe His Glu Leu Lys Gln Pro Arg Ala Pro Asp 
        675                 680                 685             


Ala Cys Glu Leu Ser Val Gln Pro Asn Gly Gly Cys Glu Tyr Leu Cys 
    690                 695                 700                 


Leu Pro Ala Pro Gln Ile Ser Ser His Ser Pro Lys Tyr Thr Cys Ala 
705                 710                 715                 720 


Cys Pro Asp Thr Met Trp Leu Gly Pro Asp Met Lys Arg Cys Tyr Arg 
                725                 730                 735     


Ala Pro Gln Ser Thr Ser Thr Thr Thr Leu Ala Ser Thr Met Thr Arg 
            740                 745                 750         


Thr Val Pro Ala Thr Thr Arg Ala Pro Gly Thr Thr Val His Arg Ser 
        755                 760                 765             


Thr Tyr Gln Asn His Ser Thr Glu Thr Pro Ser Leu Thr Ala Ala Val 
    770                 775                 780                 


Pro Ser Ser Val Ser Val Pro Arg Ala Pro Ser Ile Ser Pro Ser Thr 
785                 790                 795                 800 


Leu Ser Pro Ala Thr Ser Asn His Ser Gln His Tyr Ala Asn Glu Asp 
                805                 810                 815     


Ser Lys Met Gly Ser Thr Val Thr Ala Ala Val Ile Gly Ile Ile Val 
            820                 825                 830         


Pro Ile Val Val Ile Ala Leu Leu Cys Met Ser Gly Tyr Leu Ile Trp 
        835                 840                 845             


Arg Asn Trp Lys Arg Lys Asn Thr Lys Ser Met Asn Phe Asp Asn Pro 
    850                 855                 860                 


Val Tyr Arg Lys Thr Thr Glu Glu Glu Asp Glu Asp Glu Leu His Ile 
865                 870                 875                 880 


Gly Arg Thr Ala Gln Ile Gly His Val Tyr Pro Ala Arg Val Ala Leu 
                885                 890                 895     


Ser Leu Glu Asp Asp Gly Leu Pro 
            900                 


<210>  665
<211>  822
<212>  PRT
<213>  Homo sapiens

<400>  665

Met Ser Ser Trp Ile Arg Trp His Gly Pro Ala Met Ala Arg Leu Trp 
1               5                   10                  15      


Gly Phe Cys Trp Leu Val Val Gly Phe Trp Arg Ala Ala Phe Ala Cys 
            20                  25                  30          


Pro Thr Ser Cys Lys Cys Ser Ala Ser Arg Ile Trp Cys Ser Asp Pro 
        35                  40                  45              


Ser Pro Gly Ile Val Ala Phe Pro Arg Leu Glu Pro Asn Ser Val Asp 
    50                  55                  60                  


Pro Glu Asn Ile Thr Glu Ile Phe Ile Ala Asn Gln Lys Arg Leu Glu 
65                  70                  75                  80  


Ile Ile Asn Glu Asp Asp Val Glu Ala Tyr Val Gly Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Asp Ser Gly Leu Lys Phe Val Ala His Lys Ala Phe Leu 
            100                 105                 110         


Lys Asn Ser Asn Leu Gln His Ile Asn Phe Thr Arg Asn Lys Leu Thr 
        115                 120                 125             


Ser Leu Ser Arg Lys His Phe Arg His Leu Asp Leu Ser Glu Leu Ile 
    130                 135                 140                 


Leu Val Gly Asn Pro Phe Thr Cys Ser Cys Asp Ile Met Trp Ile Lys 
145                 150                 155                 160 


Thr Leu Gln Glu Ala Lys Ser Ser Pro Asp Thr Gln Asp Leu Tyr Cys 
                165                 170                 175     


Leu Asn Glu Ser Ser Lys Asn Ile Pro Leu Ala Asn Leu Gln Ile Pro 
            180                 185                 190         


Asn Cys Gly Leu Pro Ser Ala Asn Leu Ala Ala Pro Asn Leu Thr Val 
        195                 200                 205             


Glu Glu Gly Lys Ser Ile Thr Leu Ser Cys Ser Val Ala Gly Asp Pro 
    210                 215                 220                 


Val Pro Asn Met Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His Met 
225                 230                 235                 240 


Asn Glu Thr Ser His Thr Gln Gly Ser Leu Arg Ile Thr Asn Ile Ser 
                245                 250                 255     


Ser Asp Asp Ser Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu Val 
            260                 265                 270         


Gly Glu Asp Gln Asp Ser Val Asn Leu Thr Val His Phe Ala Pro Thr 
        275                 280                 285             


Ile Thr Phe Leu Glu Ser Pro Thr Ser Asp His His Trp Cys Ile Pro 
    290                 295                 300                 


Phe Thr Val Lys Gly Asn Pro Lys Pro Ala Leu Gln Trp Phe Tyr Asn 
305                 310                 315                 320 


Gly Ala Ile Leu Asn Glu Ser Lys Tyr Ile Cys Thr Lys Ile His Val 
                325                 330                 335     


Thr Asn His Thr Glu Tyr His Gly Cys Leu Gln Leu Asp Asn Pro Thr 
            340                 345                 350         


His Met Asn Asn Gly Asp Tyr Thr Leu Ile Ala Lys Asn Glu Tyr Gly 
        355                 360                 365             


Lys Asp Glu Lys Gln Ile Ser Ala His Phe Met Gly Trp Pro Gly Ile 
    370                 375                 380                 


Asp Asp Gly Ala Asn Pro Asn Tyr Pro Asp Val Ile Tyr Glu Asp Tyr 
385                 390                 395                 400 


Gly Thr Ala Ala Asn Asp Ile Gly Asp Thr Thr Asn Arg Ser Asn Glu 
                405                 410                 415     


Ile Pro Ser Thr Asp Val Thr Asp Lys Thr Gly Arg Glu His Leu Ser 
            420                 425                 430         


Val Tyr Ala Val Val Val Ile Ala Ser Val Val Gly Phe Cys Leu Leu 
        435                 440                 445             


Val Met Leu Phe Leu Leu Lys Leu Ala Arg His Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Gly Pro Ala Ser Val Ile Ser Asn Asp Asp Asp Ser Ala Ser Pro 
465                 470                 475                 480 


Leu His His Ile Ser Asn Gly Ser Asn Thr Pro Ser Ser Ser Glu Gly 
                485                 490                 495     


Gly Pro Asp Ala Val Ile Ile Gly Met Thr Lys Ile Pro Val Ile Glu 
            500                 505                 510         


Asn Pro Gln Tyr Phe Gly Ile Thr Asn Ser Gln Leu Lys Pro Asp Thr 
        515                 520                 525             


Phe Val Gln His Ile Lys Arg His Asn Ile Val Leu Lys Arg Glu Leu 
    530                 535                 540                 


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu 
545                 550                 555                 560 


Cys Pro Glu Gln Asp Lys Ile Leu Val Ala Val Lys Thr Leu Lys Asp 
                565                 570                 575     


Ala Ser Asp Asn Ala Arg Lys Asp Phe His Arg Glu Ala Glu Leu Leu 
            580                 585                 590         


Thr Asn Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Val 
        595                 600                 605             


Glu Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp 
    610                 615                 620                 


Leu Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala Val Leu Met Ala 
625                 630                 635                 640 


Glu Gly Asn Pro Pro Thr Glu Leu Thr Gln Ser Gln Met Leu His Ile 
                645                 650                 655     


Ala Gln Gln Ile Ala Ala Gly Met Val Tyr Leu Ala Ser Gln His Phe 
            660                 665                 670         


Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Glu Asn Leu 
        675                 680                 685             


Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val Tyr Ser Thr 
    690                 695                 700                 


Asp Tyr Tyr Arg Val Gly Gly His Thr Met Leu Pro Ile Arg Trp Met 
705                 710                 715                 720 


Pro Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val 
                725                 730                 735     


Trp Ser Leu Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln 
            740                 745                 750         


Pro Trp Tyr Gln Leu Ser Asn Asn Glu Val Ile Glu Cys Ile Thr Gln 
        755                 760                 765             


Gly Arg Val Leu Gln Arg Pro Arg Thr Cys Pro Gln Glu Val Tyr Glu 
    770                 775                 780                 


Leu Met Leu Gly Cys Trp Gln Arg Glu Pro His Met Arg Lys Asn Ile 
785                 790                 795                 800 


Lys Gly Ile His Thr Leu Leu Gln Asn Leu Ala Lys Ala Ser Pro Val 
                805                 810                 815     


Tyr Leu Asp Ile Leu Gly 
            820         


<210>  666
<211>  553
<212>  PRT
<213>  Homo sapiens

<400>  666

Met Ser Ser Trp Ile Arg Trp His Gly Pro Ala Met Ala Arg Leu Trp 
1               5                   10                  15      


Gly Phe Cys Trp Leu Val Val Gly Phe Trp Arg Ala Ala Phe Ala Cys 
            20                  25                  30          


Pro Thr Ser Cys Lys Cys Ser Ala Ser Arg Ile Trp Cys Ser Asp Pro 
        35                  40                  45              


Ser Pro Gly Ile Val Ala Phe Pro Arg Leu Glu Pro Asn Ser Val Asp 
    50                  55                  60                  


Pro Glu Asn Ile Thr Glu Ile Phe Ile Ala Asn Gln Lys Arg Leu Glu 
65                  70                  75                  80  


Ile Ile Asn Glu Asp Asp Val Glu Ala Tyr Val Gly Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Asp Ser Gly Leu Lys Phe Val Ala His Lys Ala Phe Leu 
            100                 105                 110         


Lys Asn Ser Asn Leu Gln His Ile Asn Phe Thr Arg Asn Lys Leu Thr 
        115                 120                 125             


Ser Leu Ser Arg Lys His Phe Arg His Leu Asp Leu Ser Glu Leu Ile 
    130                 135                 140                 


Leu Val Gly Asn Pro Phe Thr Cys Ser Cys Asp Ile Met Trp Ile Lys 
145                 150                 155                 160 


Thr Leu Gln Glu Ala Lys Ser Ser Pro Asp Thr Gln Asp Leu Tyr Cys 
                165                 170                 175     


Leu Asn Glu Ser Ser Lys Asn Ile Pro Leu Ala Asn Leu Gln Ile Pro 
            180                 185                 190         


Asn Cys Gly Leu Pro Ser Ala Asn Leu Ala Ala Pro Asn Leu Thr Val 
        195                 200                 205             


Glu Glu Gly Lys Ser Ile Thr Leu Ser Cys Ser Val Ala Gly Asp Pro 
    210                 215                 220                 


Val Pro Asn Met Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His Met 
225                 230                 235                 240 


Asn Glu Thr Ser His Thr Gln Gly Ser Leu Arg Ile Thr Asn Ile Ser 
                245                 250                 255     


Ser Asp Asp Ser Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu Val 
            260                 265                 270         


Gly Glu Asp Gln Asp Ser Val Asn Leu Thr Val His Phe Ala Pro Thr 
        275                 280                 285             


Ile Thr Phe Leu Glu Ser Pro Thr Ser Asp His His Trp Cys Ile Pro 
    290                 295                 300                 


Phe Thr Val Lys Gly Asn Pro Lys Pro Ala Leu Gln Trp Phe Tyr Asn 
305                 310                 315                 320 


Gly Ala Ile Leu Asn Glu Ser Lys Tyr Ile Cys Thr Lys Ile His Val 
                325                 330                 335     


Thr Asn His Thr Glu Tyr His Gly Cys Leu Gln Leu Asp Asn Pro Thr 
            340                 345                 350         


His Met Asn Asn Gly Asp Tyr Thr Leu Ile Ala Lys Asn Glu Tyr Gly 
        355                 360                 365             


Lys Asp Glu Lys Gln Ile Ser Ala His Phe Met Gly Trp Pro Gly Ile 
    370                 375                 380                 


Asp Asp Gly Ala Asn Pro Asn Tyr Pro Asp Val Ile Tyr Glu Asp Tyr 
385                 390                 395                 400 


Gly Thr Ala Ala Asn Asp Ile Gly Asp Thr Thr Asn Arg Ser Asn Glu 
                405                 410                 415     


Ile Pro Ser Thr Asp Val Thr Asp Lys Thr Gly Arg Glu His Leu Ser 
            420                 425                 430         


Val Tyr Ala Val Val Val Ile Ala Ser Val Val Gly Phe Cys Leu Leu 
        435                 440                 445             


Val Met Leu Phe Leu Leu Lys Leu Ala Arg His Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Asp Phe Ser Trp Phe Gly Phe Gly Lys Val Lys Ser Arg Gln Gly 
465                 470                 475                 480 


Val Gly Pro Ala Ser Val Ile Ser Asn Asp Asp Asp Ser Ala Ser Pro 
                485                 490                 495     


Leu His His Ile Ser Asn Gly Ser Asn Thr Pro Ser Ser Ser Glu Gly 
            500                 505                 510         


Gly Pro Asp Ala Val Ile Ile Gly Met Thr Lys Ile Pro Val Ile Glu 
        515                 520                 525             


Asn Pro Gln Tyr Phe Gly Ile Thr Asn Ser Gln Leu Lys Pro Asp Thr 
    530                 535                 540                 


Trp Pro Arg Gly Ser Pro Lys Thr Ala 
545                 550             


<210>  667
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  667

Met Ser Ser Trp Ile Arg Trp His Gly Pro Ala Met Ala Arg Leu Trp 
1               5                   10                  15      


Gly Phe Cys Trp Leu Val Val Gly Phe Trp Arg Ala Ala Phe Ala Cys 
            20                  25                  30          


Pro Thr Ser Cys Lys Cys Ser Ala Ser Arg Ile Trp Cys Ser Asp Pro 
        35                  40                  45              


Ser Pro Gly Ile Val Ala Phe Pro Arg Leu Glu Pro Asn Ser Val Asp 
    50                  55                  60                  


Pro Glu Asn Ile Thr Glu Ile Phe Ile Ala Asn Gln Lys Arg Leu Glu 
65                  70                  75                  80  


Ile Ile Asn Glu Asp Asp Val Glu Ala Tyr Val Gly Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Asp Ser Gly Leu Lys Phe Val Ala His Lys Ala Phe Leu 
            100                 105                 110         


Lys Asn Ser Asn Leu Gln His Ile Asn Phe Thr Arg Asn Lys Leu Thr 
        115                 120                 125             


Ser Leu Ser Arg Lys His Phe Arg His Leu Asp Leu Ser Glu Leu Ile 
    130                 135                 140                 


Leu Val Gly Asn Pro Phe Thr Cys Ser Cys Asp Ile Met Trp Ile Lys 
145                 150                 155                 160 


Thr Leu Gln Glu Ala Lys Ser Ser Pro Asp Thr Gln Asp Leu Tyr Cys 
                165                 170                 175     


Leu Asn Glu Ser Ser Lys Asn Ile Pro Leu Ala Asn Leu Gln Ile Pro 
            180                 185                 190         


Asn Cys Gly Leu Pro Ser Ala Asn Leu Ala Ala Pro Asn Leu Thr Val 
        195                 200                 205             


Glu Glu Gly Lys Ser Ile Thr Leu Ser Cys Ser Val Ala Gly Asp Pro 
    210                 215                 220                 


Val Pro Asn Met Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His Met 
225                 230                 235                 240 


Asn Glu Thr Ser His Thr Gln Gly Ser Leu Arg Ile Thr Asn Ile Ser 
                245                 250                 255     


Ser Asp Asp Ser Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu Val 
            260                 265                 270         


Gly Glu Asp Gln Asp Ser Val Asn Leu Thr Val His Phe Ala Pro Thr 
        275                 280                 285             


Ile Thr Phe Leu Glu Ser Pro Thr Ser Asp His His Trp Cys Ile Pro 
    290                 295                 300                 


Phe Thr Val Lys Gly Asn Pro Lys Pro Ala Leu Gln Trp Phe Tyr Asn 
305                 310                 315                 320 


Gly Ala Ile Leu Asn Glu Ser Lys Tyr Ile Cys Thr Lys Ile His Val 
                325                 330                 335     


Thr Asn His Thr Glu Tyr His Gly Cys Leu Gln Leu Asp Asn Pro Thr 
            340                 345                 350         


His Met Asn Asn Gly Asp Tyr Thr Leu Ile Ala Lys Asn Glu Tyr Gly 
        355                 360                 365             


Lys Asp Glu Lys Gln Ile Ser Ala His Phe Met Gly Trp Pro Gly Ile 
    370                 375                 380                 


Asp Asp Gly Ala Asn Pro Asn Tyr Pro Asp Val Ile Tyr Glu Asp Tyr 
385                 390                 395                 400 


Gly Thr Ala Ala Asn Asp Ile Gly Asp Thr Thr Asn Arg Ser Asn Glu 
                405                 410                 415     


Ile Pro Ser Thr Asp Val Thr Asp Lys Thr Gly Arg Glu His Leu Ser 
            420                 425                 430         


Val Tyr Ala Val Val Val Ile Ala Ser Val Val Gly Phe Cys Leu Leu 
        435                 440                 445             


Val Met Leu Phe Leu Leu Lys Leu Ala Arg His Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Gly Pro Ala Ser Val Ile Ser Asn Asp Asp Asp Ser Ala Ser Pro 
465                 470                 475                 480 


Leu His His Ile Ser Asn Gly Ser Asn Thr Pro Ser Ser Ser Glu Gly 
                485                 490                 495     


Gly Pro Asp Ala Val Ile Ile Gly Met Thr Lys Ile Pro Val Ile Glu 
            500                 505                 510         


Asn Pro Gln Tyr Phe Gly Ile Thr Asn Ser Gln Leu Lys Pro Asp Thr 
        515                 520                 525             


Trp Pro Arg Gly Ser Pro Lys Thr Ala 
    530                 535         


<210>  668
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  668

Met Lys Tyr Pro Leu Met Pro Leu Val Asn Asp Leu Thr Phe Ser Phe 
1               5                   10                  15      


Leu Val Phe Trp Phe Cys Leu Pro Val Gly Leu Leu Leu Leu Leu Ile 
            20                  25                  30          


Ile Trp Leu Arg Phe Leu Leu Ser Gln Asp Ser Glu Glu Asn Asp Ser 
        35                  40                  45              


Ser Val Cys Leu Asp Trp Glu Pro Trp Ser Lys Gly Pro Ala Glu Phe 
    50                  55                  60                  


Cys Trp Lys Gly Thr Leu His Gly Gln Glu Lys Glu Arg Pro Cys Trp 
65                  70                  75                  80  


<210>  669
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  669

Met Arg Cys Ala Leu Ala Leu Ser Ala Leu Leu Leu Leu Leu Ser Thr 
1               5                   10                  15      


Pro Pro Leu Leu Pro Ser Ser Pro Ser Pro Ser Pro Ser Pro Ser Gln 
            20                  25                  30          


Asn Ala Thr Gln Thr Thr Thr Asp Ser Ser Asn Lys Thr Ala Pro Thr 
        35                  40                  45              


Pro Ala Ser Ser Val Thr Ile Met Ala Thr Asp Thr Ala Gln Gln Ser 
    50                  55                  60                  


Thr Val Pro Thr Ser Lys Ala Asn Glu Ile Leu Ala Ser Val Lys Ala 
65                  70                  75                  80  


Thr Thr Leu Gly Val Ser Ser Asp Ser Pro Gly Thr Thr Thr Leu Ala 
                85                  90                  95      


Gln Gln Val Ser Gly Pro Val Asn Thr Thr Val Ala Arg Gly Gly Gly 
            100                 105                 110         


Ser Gly Asn Pro Thr Thr Thr Ile Glu Ser Pro Lys Ser Thr Lys Ser 
        115                 120                 125             


Ala Asp Thr Thr Thr Val Ala Thr Ser Thr Ala Thr Ala Lys Pro Asn 
    130                 135                 140                 


Thr Thr Ser Ser Gln Asn Gly Ala Glu Asp Thr Thr Asn Ser Gly Gly 
145                 150                 155                 160 


Lys Ser Ser His Ser Val Thr Thr Asp Leu Thr Ser Thr Lys Ala Glu 
                165                 170                 175     


His Leu Thr Thr Pro His Pro Thr Ser Pro Leu Ser Pro Arg Gln Pro 
            180                 185                 190         


Thr Ser Thr His Pro Val Ala Thr Pro Thr Ser Ser Gly His Asp His 
        195                 200                 205             


Leu Met Lys Ile Ser Ser Ser Ser Ser Thr Val Ala Ile Pro Gly Tyr 
    210                 215                 220                 


Thr Phe Thr Ser Pro Gly Met Thr Thr Thr Leu Leu Glu Thr Val Phe 
225                 230                 235                 240 


His His Val Ser Gln Ala Gly Leu Glu Leu Leu Thr Ser Gly Asp Leu 
                245                 250                 255     


Pro Thr Leu Ala Ser Gln Ser Ala Gly Ile Thr Ala Ser Ser Val Ile 
            260                 265                 270         


Ser Gln Arg Thr Gln Gln Thr Ser Ser Gln Met Pro Ala Ser Ser Thr 
        275                 280                 285             


Ala Pro Ser Ser Gln Glu Thr Val Gln Pro Thr Ser Pro Ala Thr Ala 
    290                 295                 300                 


Leu Arg Thr Pro Thr Leu Pro Glu Thr Met Ser Ser Ser Pro Thr Ala 
305                 310                 315                 320 


Ala Ser Thr Thr His Arg Tyr Pro Lys Thr Pro Ser Pro Thr Val Ala 
                325                 330                 335     


His Glu Ser Asn Trp Ala Lys Cys Glu Asp Leu Glu Thr Gln Thr Gln 
            340                 345                 350         


Ser Glu Lys Gln Leu Val Leu Asn Leu Thr Gly Asn Thr Leu Cys Ala 
        355                 360                 365             


Gly Gly Ala Ser Asp Glu Lys Leu Ile Ser Leu Ile Cys Arg Ala Val 
    370                 375                 380                 


Lys Ala Thr Phe Asn Pro Ala Gln Asp Lys Cys Gly Ile Arg Leu Ala 
385                 390                 395                 400 


Ser Val Pro Gly Ser Gln Thr Val Val Val Lys Glu Ile Thr Ile His 
                405                 410                 415     


Thr Lys Leu Pro Ala Lys Asp Val Tyr Glu Arg Leu Lys Asp Lys Trp 
            420                 425                 430         


Asp Glu Leu Lys Glu Ala Gly Val Ser Asp Met Lys Leu Gly Asp Gln 
        435                 440                 445             


Gly Pro Pro Glu Glu Ala Glu Asp Arg Phe Ser Met Pro Leu Ile Ile 
    450                 455                 460                 


Thr Ile Val Cys Met Ala Ser Phe Leu Leu Leu Val Ala Ala Leu Tyr 
465                 470                 475                 480 


Gly Cys Cys His Gln Arg Leu Ser Gln Arg Lys Asp Gln Gln Arg Leu 
                485                 490                 495     


Thr Glu Glu Leu Gln Thr Val Glu Asn Gly Tyr His Asp Asn Pro Thr 
            500                 505                 510         


Leu Glu Val Met Glu Thr Ser Ser Glu Met Gln Glu Lys Lys Val Val 
        515                 520                 525             


Ser Leu Asn Gly Glu Leu Gly Asp Ser Trp Ile Val Pro Leu Asp Asn 
    530                 535                 540                 


Leu Thr Lys Asp Asp Leu Asp Glu Glu Glu Asp Thr His Leu 
545                 550                 555             


<210>  670
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  670

Met Gly Arg Leu Val Ala Val Gly Leu Leu Gly Ile Ala Leu Ala Leu 
1               5                   10                  15      


Leu Gly Glu Arg Leu Leu Ala Leu Arg Asn Arg Leu Lys Ala Ser Arg 
            20                  25                  30          


Glu Val Glu Ser Val Asp Leu Pro His Cys His Leu Ile Lys Gly Ile 
        35                  40                  45              


Glu Ala Gly Ser Glu Asp Ile Asp Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Phe Ser Val Gly Leu Lys Phe Pro Gly Leu His Ser Phe Ala Pro Asp 
65                  70                  75                  80  


Lys Pro Gly Gly Ile Leu Met Met Asp Leu Lys Glu Glu Lys Pro Arg 
                85                  90                  95      


Ala Arg Glu Leu Arg Ile Ser Arg Gly Phe Asp Leu Ala Ser Phe Asn 
            100                 105                 110         


Pro His Gly Ile Ser Thr Phe Ile Asp Asn Glu Phe Lys Asn Thr Val 
        115                 120                 125             


Glu Ile Phe Lys Phe Glu Glu Ala Glu Asn Ser Leu Leu His Leu Lys 
    130                 135                 140                 


Thr Val Lys His Glu Leu Leu Pro Ser Val Asn Asp Ile Thr Ala Val 
145                 150                 155                 160 


Gly Pro Ala His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ser Asp Pro 
                165                 170                 175     


Phe Leu Lys Tyr Leu Glu Thr Tyr Leu Asn Leu His Trp Ala Asn Val 
            180                 185                 190         


Val Tyr Tyr Ser Pro Asn Glu Val Lys Val Val Ala Glu Gly Phe Asp 
        195                 200                 205             


Ser Ala Asn Gly Ile Asn Ile Ser Pro Asp Asp Lys Tyr Ile Tyr Val 
    210                 215                 220                 


Ala Asp Ile Leu Ala His Glu Ile His Val Leu Glu Lys His Thr Asn 
225                 230                 235                 240 


Met Asn Leu Thr Gln Leu Lys Val Leu Glu Leu Asp Thr Leu Val Asp 
                245                 250                 255     


Asn Leu Ser Ile Asp Pro Ser Ser Gly Asp Ile Trp Val Gly Cys His 
            260                 265                 270         


Pro Asn Gly Gln Lys Leu Phe Val Tyr Asp Pro Asn Asn Pro Pro Ser 
        275                 280                 285             


Ser Glu Val Leu Arg Ile Gln Asn Ile Leu Ser Glu Lys Pro Thr Val 
    290                 295                 300                 


Thr Thr Val Tyr Ala Asn Asn Gly Ser Val Leu Gln Gly Ser Ser Val 
305                 310                 315                 320 


Ala Ser Val Tyr Asp Gly Lys Leu Leu Ile Gly Thr Leu Tyr His Arg 
                325                 330                 335     


Ala Leu Tyr Cys Glu Leu 
            340         


<210>  671
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  671

Met Pro Val Thr Val Thr Arg Thr Thr Ile Thr Thr Thr Thr Thr Ser 
1               5                   10                  15      


Ser Ser Gly Leu Gly Ser Pro Met Ile Val Gly Ser Pro Arg Ala Leu 
            20                  25                  30          


Thr Gln Pro Leu Gly Leu Leu Arg Leu Leu Gln Leu Val Ser Thr Cys 
        35                  40                  45              


Val Ala Phe Ser Leu Val Ala Ser Val Gly Ala Trp Thr Gly Ser Met 
    50                  55                  60                  


Gly Asn Trp Ser Met Phe Thr Trp Cys Phe Cys Phe Ser Val Thr Leu 
65                  70                  75                  80  


Ile Ile Leu Ile Val Glu Leu Cys Gly Leu Gln Ala Arg Phe Pro Leu 
                85                  90                  95      


Ser Trp Arg Asn Phe Pro Ile Thr Phe Ala Cys Tyr Ala Ala Leu Phe 
            100                 105                 110         


Cys Leu Ser Ala Ser Ile Ile Tyr Pro Thr Thr Tyr Val Gln Phe Leu 
        115                 120                 125             


Ser His Gly Arg Ser Arg Asp His Ala Ile Ala Ala Thr Phe Phe Ser 
    130                 135                 140                 


Cys Ile Ala Cys Val Ala Tyr Ala Thr Glu Val Ala Trp Thr Arg Ala 
145                 150                 155                 160 


Arg Pro Gly Glu Ile Thr Gly Tyr Met Ala Thr Val Pro Gly Leu Leu 
                165                 170                 175     


Lys Val Leu Glu Thr Phe Val Ala Cys Ile Ile Phe Ala Phe Ile Ser 
            180                 185                 190         


Asp Pro Asn Leu Tyr Gln His Gln Pro Ala Leu Glu Trp Cys Val Ala 
        195                 200                 205             


Val Tyr Ala Ile Cys Phe Ile Leu Ala Ala Ile Ala Ile Leu Leu Asn 
    210                 215                 220                 


Leu Gly Glu Cys Thr Asn Val Leu Pro Ile Pro Phe Pro Ser Phe Leu 
225                 230                 235                 240 


Ser Gly Leu Ala Leu Leu Ser Val Leu Leu Tyr Ala Thr Ala Leu Val 
                245                 250                 255     


Leu Trp Pro Leu Tyr Gln Phe Asp Glu Lys Tyr Gly Gly Gln Pro Arg 
            260                 265                 270         


Arg Ser Arg Asp Val Ser Cys Ser Arg Ser His Ala Tyr Tyr Val Cys 
        275                 280                 285             


Ala Trp Asp Arg Arg Leu Ala Val Ala Ile Leu Thr Ala Ile Asn Leu 
    290                 295                 300                 


Leu Ala Tyr Val Ala Asp Leu Val His Ser Ala His Leu Val Phe Val 
305                 310                 315                 320 


Lys Val 
        


<210>  672
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  672

Met Pro Val Thr Val Thr Arg Thr Thr Ile Thr Thr Thr Thr Thr Ser 
1               5                   10                  15      


Ser Ser Gly Leu Gly Ser Pro Met Ile Val Gly Ser Pro Arg Ala Leu 
            20                  25                  30          


Thr Gln Pro Leu Gly Leu Leu Arg Leu Leu Gln Leu Val Ser Thr Cys 
        35                  40                  45              


Val Ala Phe Ser Leu Val Ala Ser Val Gly Ala Trp Thr Gly Ser Met 
    50                  55                  60                  


Gly Asn Trp Ser Met Phe Thr Trp Cys Phe Cys Phe Ser Val Thr Leu 
65                  70                  75                  80  


Ile Ile Leu Ile Val Glu Leu Cys Gly Leu Gln Ala Arg Phe Pro Leu 
                85                  90                  95      


Ser Trp Arg Asn Phe Pro Ile Thr Phe Ala Cys Tyr Ala Ala Leu Phe 
            100                 105                 110         


Cys Leu Ser Ala Ser Ile Ile Tyr Pro Thr Thr Tyr Val Gln Phe Leu 
        115                 120                 125             


Ser His Gly Arg Ser Arg Asp His Ala Ile Ala Ala Thr Phe Phe Ser 
    130                 135                 140                 


Cys Ile Ala Cys Val Ala Tyr Ala Thr Glu Val Ala Trp Thr Arg Ala 
145                 150                 155                 160 


Arg Pro Gly Glu Ile Thr Gly Tyr Met Ala Thr Val Pro Gly Leu Leu 
                165                 170                 175     


Lys Val Leu Glu Thr Phe Val Ala Cys Ile Ile Phe Ala Phe Ile Ser 
            180                 185                 190         


Asp Pro Asn Leu Tyr Gln His Gln Pro Ala Leu Glu Trp Cys Val Ala 
        195                 200                 205             


Val Tyr Ala Ile Cys Phe Ile Leu Ala Ala Ile Ala Ile Leu Leu Asn 
    210                 215                 220                 


Leu Gly Glu Cys Thr Asn Val Leu Pro Ile Pro Phe Pro Ser Phe Leu 
225                 230                 235                 240 


Ser Gly Leu Ala Leu Leu Ser Val Leu Leu Tyr Ala Thr Ala Leu Val 
                245                 250                 255     


Leu Trp Pro Leu Tyr Gln Phe Asp Glu Lys Tyr Gly Gly Gln Pro Arg 
            260                 265                 270         


Arg Ser Arg Asp Val Ser Cys Ser Arg Ser His Ala Tyr Tyr Val Cys 
        275                 280                 285             


Ala Trp Asp Arg Arg Leu Ala Val Ala Ile Leu Thr Ala Ile Asn Leu 
    290                 295                 300                 


Leu Ala Tyr Val Ala Asp Leu Val His Ser Ala His Leu Val Phe Val 
305                 310                 315                 320 


Lys Val 
        


<210>  673
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  673

Met Pro Val Thr Val Thr Arg Thr Thr Ile Thr Thr Thr Thr Thr Ser 
1               5                   10                  15      


Ser Ser Gly Leu Gly Ser Pro Met Ile Val Gly Ser Pro Arg Ala Leu 
            20                  25                  30          


Thr Gln Pro Leu Gly Leu Leu Arg Leu Leu Gln Leu Val Ser Thr Cys 
        35                  40                  45              


Val Ala Phe Ser Leu Val Ala Ser Val Gly Ala Trp Thr Gly Ser Met 
    50                  55                  60                  


Gly Asn Trp Ser Met Phe Thr Trp Cys Phe Cys Phe Ser Val Thr Leu 
65                  70                  75                  80  


Ile Ile Leu Ile Val Glu Leu Cys Gly Leu Gln Ala Arg Phe Pro Leu 
                85                  90                  95      


Ser Trp Arg Asn Phe Pro Ile Thr Phe Ala Cys Tyr Ala Ala Leu Phe 
            100                 105                 110         


Cys Leu Ser Ala Ser Ile Ile Tyr Pro Thr Thr Tyr Val Gln Phe Leu 
        115                 120                 125             


Ser His Gly Arg Ser Arg Asp His Ala Ile Ala Ala Thr Phe Phe Ser 
    130                 135                 140                 


Cys Ile Ala Cys Val Ala Tyr Ala Thr Glu Val Ala Trp Thr Arg Ala 
145                 150                 155                 160 


Arg Pro Gly Glu Ile Thr Gly Tyr Met Ala Thr Val Pro Gly Leu Leu 
                165                 170                 175     


Lys Val Leu Glu Thr Phe Val Ala Cys Ile Ile Phe Ala Phe Ile Ser 
            180                 185                 190         


Asp Pro Asn Leu Tyr Gln His Gln Pro Ala Leu Glu Trp Cys Val Ala 
        195                 200                 205             


Val Tyr Ala Ile Cys Phe Ile Leu Ala Ala Ile Ala Ile Leu Leu Asn 
    210                 215                 220                 


Leu Gly Glu Cys Thr Asn Val Leu Pro Ile Pro Phe Pro Ser Phe Leu 
225                 230                 235                 240 


Ser Gly Leu Ala Leu Leu Ser Val Leu Leu Tyr Ala Thr Ala Leu Val 
                245                 250                 255     


Leu Trp Pro Leu Tyr Gln Phe Asp Glu Lys Tyr Gly Gly Gln Pro Arg 
            260                 265                 270         


Arg Ser Arg Asp Val Ser Cys Ser Arg Ser His Ala Tyr Tyr Val Cys 
        275                 280                 285             


Ala Trp Asp Arg Arg Leu Ala Val Ala Ile Leu Thr Ala Ile Asn Leu 
    290                 295                 300                 


Leu Ala Tyr Val Ala Asp Leu Val His Ser Ala His Leu Val Phe Val 
305                 310                 315                 320 


Lys Val 
        


<210>  674
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  674

Met Pro Val Thr Val Thr Arg Thr Thr Ile Thr Thr Thr Thr Thr Ser 
1               5                   10                  15      


Ser Ser Gly Leu Gly Ser Pro Met Ile Val Gly Ser Pro Arg Ala Leu 
            20                  25                  30          


Thr Gln Pro Leu Gly Leu Leu Arg Leu Leu Gln Leu Val Ser Thr Cys 
        35                  40                  45              


Val Ala Phe Ser Leu Val Ala Ser Val Gly Ala Trp Thr Gly Ser Met 
    50                  55                  60                  


Gly Asn Trp Ser Met Phe Thr Trp Cys Phe Cys Phe Ser Val Thr Leu 
65                  70                  75                  80  


Ile Ile Leu Ile Val Glu Leu Cys Gly Leu Gln Ala Arg Phe Pro Leu 
                85                  90                  95      


Ser Trp Arg Asn Phe Pro Ile Thr Phe Ala Cys Tyr Ala Ala Leu Phe 
            100                 105                 110         


Cys Leu Ser Ala Ser Ile Ile Tyr Pro Thr Thr Tyr Val Gln Phe Leu 
        115                 120                 125             


Ser His Gly Arg Ser Arg Asp His Ala Ile Ala Ala Thr Phe Phe Ser 
    130                 135                 140                 


Cys Ile Ala Cys Val Ala Tyr Ala Thr Glu Val Ala Trp Thr Arg Ala 
145                 150                 155                 160 


Arg Pro Gly Glu Ile Thr Gly Tyr Met Ala Thr Val Pro Gly Leu Leu 
                165                 170                 175     


Lys Val Leu Glu Thr Phe Val Ala Cys Ile Ile Phe Ala Phe Ile Ser 
            180                 185                 190         


Asp Pro Asn Leu Tyr Gln His Gln Pro Ala Leu Glu Trp Cys Val Ala 
        195                 200                 205             


Val Tyr Ala Ile Cys Phe Ile Leu Ala Ala Ile Ala Ile Leu Leu Asn 
    210                 215                 220                 


Leu Gly Glu Cys Thr Asn Val Leu Pro Ile Pro Phe Pro Ser Phe Leu 
225                 230                 235                 240 


Ser Gly Leu Ala Leu Leu Ser Val Leu Leu Tyr Ala Thr Ala Leu Val 
                245                 250                 255     


Leu Trp Pro Leu Tyr Gln Phe Asp Glu Lys Tyr Gly Gly Gln Pro Arg 
            260                 265                 270         


Arg Ser Arg Asp Val Ser Cys Ser Arg Ser His Ala Tyr Tyr Val Cys 
        275                 280                 285             


Ala Trp Asp Arg Arg Leu Ala Val Ala Ile Leu Thr Ala Ile Asn Leu 
    290                 295                 300                 


Leu Ala Tyr Val Ala Asp Leu Val His Ser Ala His Leu Val Phe Val 
305                 310                 315                 320 


Lys Val 
        


<210>  675
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  675

Met Lys Asp Ile Asp Ile Gly Lys Glu Tyr Ile Ile Pro Ser Pro Gly 
1               5                   10                  15      


Tyr Arg Ser Val Arg Glu Arg Thr Ser Thr Ser Gly Thr His Arg Asp 
            20                  25                  30          


Arg Glu Asp Ser Lys Phe Arg Arg Thr Arg Pro Leu Glu Cys Gln Asp 
        35                  40                  45              


Ala Leu Glu Thr Ala Ala Arg Ala Glu Gly Leu Ser Leu Asp Ala Ser 
    50                  55                  60                  


Met His Ser Gln Leu Arg Ile Leu Asp Glu Glu His Pro Lys Gly Lys 
65                  70                  75                  80  


Tyr His His Gly Leu Ser Ala Leu Lys Pro Ile Arg Thr Thr Ser Lys 
                85                  90                  95      


His Gln His Pro Val Asp Asn Ala Gly Leu Phe Ser Cys Met Thr Phe 
            100                 105                 110         


Ser Trp Leu Ser Ser Leu Ala Arg Val Ala His Lys Lys Gly Glu Leu 
        115                 120                 125             


Ser Met Glu Asp Val Trp Ser Leu Ser Lys His Glu Ser Ser Asp Val 
    130                 135                 140                 


Asn Cys Arg Arg Leu Glu Arg Leu Trp Gln Glu Glu Leu Asn Glu Val 
145                 150                 155                 160 


Gly Pro Asp Ala Ala Ser Leu Arg Arg Val Val Trp Ile Phe Cys Arg 
                165                 170                 175     


Thr Arg Leu Ile Leu Ser Ile Val Cys Leu Met Ile Thr Gln Leu Ala 
            180                 185                 190         


Gly Phe Ser Gly Pro Asn Phe Gln Asp Gly Cys Ile Leu Arg Ser Glu 
        195                 200                 205             


<210>  676
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  676

Met Lys Lys Cys Leu Leu Pro Val Leu Ile Thr Cys Met Gln Thr Ala 
1               5                   10                  15      


Ile Cys Lys Asp Arg Met Met Met Ile Met Ile Leu Leu Val Asn Tyr 
            20                  25                  30          


Arg Pro Asp Glu Phe Ile Glu Cys Glu Asp Pro Val Asp His Val Gly 
        35                  40                  45              


Asn Ala Thr Ala Ser Gln Glu Leu Gly Tyr Gly Cys Leu Lys Phe Gly 
    50                  55                  60                  


Gly Gln Ala Tyr Ser Asp Val Glu His Thr Ser Val Gln Cys His Ala 
65                  70                  75                  80  


Leu Asp Gly Ile Glu Cys Ala Ser Pro Arg Thr Phe Leu Arg Glu Asn 
                85                  90                  95      


Lys Pro Cys Ile Lys Tyr Thr Gly His Tyr Phe Ile Thr Thr Leu Leu 
            100                 105                 110         


Tyr Ser Phe Phe Leu Gly Cys Phe Gly Val Asp Arg Phe Cys Leu Gly 
        115                 120                 125             


His Thr Gly Thr Ala Val Gly Lys Leu Leu Thr Leu Gly Gly Leu Gly 
    130                 135                 140                 


Ile Trp Trp Phe Val Asp Leu Ile Leu Leu Ile Thr Gly Gly Leu Met 
145                 150                 155                 160 


Pro Ser Asp Gly Ser Asn Trp Cys Thr Val Tyr 
                165                 170     


<210>  677
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  677

Met Lys Lys Cys Leu Leu Pro Val Leu Ile Thr Cys Met Gln Thr Ala 
1               5                   10                  15      


Ile Cys Lys Asp Arg Met Met Met Ile Met Ile Leu Leu Val Asn Tyr 
            20                  25                  30          


Arg Pro Asp Glu Phe Ile Glu Cys Glu Asp Pro Val Asp His Val Gly 
        35                  40                  45              


Asn Ala Thr Ala Ser Gln Glu Leu Gly Tyr Gly Cys Leu Lys Phe Gly 
    50                  55                  60                  


Gly Gln Ala Tyr Ser Asp Val Glu His Thr Ser Val Gln Cys His Ala 
65                  70                  75                  80  


Leu Asp Gly Ile Glu Cys Ala Ser Pro Arg Thr Phe Leu Arg Glu Asn 
                85                  90                  95      


Lys Pro Cys Ile Lys Tyr Thr Gly His Tyr Phe Ile Thr Thr Leu Leu 
            100                 105                 110         


Tyr Ser Phe Phe Leu Gly Cys Phe Gly Val Asp Arg Phe Cys Leu Gly 
        115                 120                 125             


His Thr Gly Thr Ala Val Gly Lys Leu Leu Thr Leu Gly Gly Leu Gly 
    130                 135                 140                 


Ile Trp Trp Phe Val Asp Leu Ile Leu Leu Ile Thr Gly Gly Leu Met 
145                 150                 155                 160 


Pro Ser Asp Gly Ser Asn Trp Cys Thr Val Tyr 
                165                 170     


<210>  678
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  678

Met Gly Val Asn Leu Leu Ala Ala Asn Thr His Asn Thr Ser Met His 
1               5                   10                  15      


Met Thr Gly Ser Gly Ile Tyr Ala Pro Glu Ala Val Lys Val Tyr His 
            20                  25                  30          


Tyr Asp Met Glu Thr Glu Ser Gly Gln Leu Leu Leu Ser Glu Leu Lys 
        35                  40                  45              


Ser Arg Pro Arg Arg Glu Pro Thr Tyr Pro Ala Ala Val Asp Trp His 
    50                  55                  60                  


Ala Tyr Ala Ser Ser Val Lys Pro Phe Ser Ser Glu Gln Ser Asp Phe 
65                  70                  75                  80  


Leu Gly Met Ile Tyr Phe Asp Glu Phe Thr Phe Thr Lys Leu Lys Arg 
                85                  90                  95      


Asn Thr Gly Asn Tyr Thr Ala Cys Gln Lys Asp Leu Cys Cys His Leu 
            100                 105                 110         


Thr Tyr Lys Met Ser Glu Lys Arg Thr Asp Glu Ile Tyr Ala Leu Gly 
        115                 120                 125             


Ala Phe Asp Gly Leu His Thr Val Glu Gly Gln Tyr Tyr Leu Gln Ile 
    130                 135                 140                 


Cys Ala Leu Leu Lys Cys Gln Thr Thr Asp Leu Glu Thr Cys Gly Glu 
145                 150                 155                 160 


Pro Val Gly Ser Ala Phe Thr Lys Phe Glu Asp Phe Ser Leu Ser Gly 
                165                 170                 175     


Thr Phe Gly Thr Arg Tyr Val Phe Pro Gln Ile Ile Leu Ser Gly Ser 
            180                 185                 190         


Gln Leu Ala Pro Glu Arg His Tyr Glu Ile Ser Arg Asp Gly Arg Leu 
        195                 200                 205             


Arg Ser Arg Ser Gly Ala Pro Leu Pro Val Leu Val Met Ala Leu Tyr 
    210                 215                 220                 


Gly Arg Val Phe Glu Lys Asp Pro Pro Arg Leu Gly Gln Gly Ser Gly 
225                 230                 235                 240 


Lys Phe Gln 
            


<210>  679
<211>  880
<212>  PRT
<213>  Homo sapiens

<400>  679

Met Lys Asn Leu Tyr Phe Arg Val Ile Thr Ile Val Ile Gly Leu Tyr 
1               5                   10                  15      


Phe Thr Gly Ile Met Thr Asn Ala Ser Arg Lys Ser Asn Ile Leu Phe 
            20                  25                  30          


Asn Ser Glu Cys Gln Trp Asn Glu Tyr Ile Leu Thr Asn Cys Ser Phe 
        35                  40                  45              


Thr Gly Lys Cys Asp Ile Pro Val Asp Ile Ser Gln Thr Ala Ala Thr 
    50                  55                  60                  


Val Asp Val Ser Phe Asn Phe Phe Arg Val Leu Leu Gln Ser His Thr 
65                  70                  75                  80  


Lys Lys Glu Glu Trp Lys Ile Lys His Leu Asp Leu Ser Asn Asn Leu 
                85                  90                  95      


Ile Ser Lys Ile Thr Leu Ser Pro Phe Ala Tyr Leu His Ala Leu Glu 
            100                 105                 110         


Val Leu Asn Leu Ser Asn Asn Ala Ile His Ser Leu Ser Leu Asp Leu 
        115                 120                 125             


Leu Ser Pro Lys Ser Ser Trp Val Lys Arg His Arg Ser Ser Phe Arg 
    130                 135                 140                 


Asn Arg Phe Pro Leu Leu Lys Val Leu Ile Leu Gln Arg Asn Lys Leu 
145                 150                 155                 160 


Ser Asp Thr Pro Lys Gly Leu Trp Lys Leu Lys Ser Leu Gln Ser Leu 
                165                 170                 175     


Asp Leu Ser Phe Asn Gly Ile Leu Gln Ile Gly Trp Ser Asp Phe His 
            180                 185                 190         


Asn Cys Leu Gln Leu Glu Asn Leu Cys Leu Lys Ser Asn Lys Ile Phe 
        195                 200                 205             


Lys Ile Pro Pro Gln Ala Phe Lys Asp Leu Lys Lys Leu Gln Val Ile 
    210                 215                 220                 


Asp Leu Ser Asn Asn Ala Leu Ile Thr Ile Leu Pro Met Met Ile Ile 
225                 230                 235                 240 


Ala Leu Glu Phe Pro His Leu Val Val Asp Leu Ala Asp Asn Asn Trp 
                245                 250                 255     


Gln Cys Asp Asp Ser Val Ala Val Phe Gln Asn Phe Ile Ser Glu Ser 
            260                 265                 270         


Trp Arg Lys Lys Trp Asn Val Ile Cys Asn Arg Ser Ile Gly Ser Glu 
        275                 280                 285             


Glu Ala Asn Gly Gly Thr Pro Gln Ser Arg Ile Ser Arg Glu Thr Arg 
    290                 295                 300                 


Leu Pro Pro Ile His Leu His Arg Met Lys Ser Leu Ile Arg Ser Lys 
305                 310                 315                 320 


Ala Glu Arg Pro Gln Gly Gly Arg His Thr Gly Ile Ser Thr Leu Gly 
                325                 330                 335     


Lys Lys Ala Lys Ala Gly Ser Gly Leu Arg Lys Lys Gln Arg Arg Leu 
            340                 345                 350         


Pro Arg Ser Val Arg Ser Thr Arg Asp Val Gln Ala Ala Gly Lys Lys 
        355                 360                 365             


Glu Asp Ala Pro Gln Asp Leu Ala Leu Ala Val Cys Leu Ser Val Phe 
    370                 375                 380                 


Ile Thr Phe Leu Val Ala Phe Ser Leu Gly Ala Phe Thr Arg Pro Tyr 
385                 390                 395                 400 


Val Asp Arg Leu Trp Gln Lys Lys Cys Gln Ser Lys Ser Pro Gly Leu 
                405                 410                 415     


Asp Asn Ala Tyr Ser Asn Glu Gly Phe Tyr Asp Asp Met Glu Ala Ala 
            420                 425                 430         


Gly His Thr Pro His Pro Glu Thr His Leu Arg Gln Val Phe Pro His 
        435                 440                 445             


Leu Ser Leu Tyr Glu Asn Gln Thr Pro Phe Trp Val Thr Gln Pro His 
    450                 455                 460                 


Pro His Ala Thr Val Ile Pro Asp Arg Thr Leu Gly Arg Ser Arg Lys 
465                 470                 475                 480 


Asp Pro Gly Ser Ser Gln Ser Pro Gly Gln Cys Gly Asp Asn Thr Gly 
                485                 490                 495     


Ala Gly Ser Gly Asn Asp Gly Ala Val Tyr Ser Ile Leu Gln Arg His 
            500                 505                 510         


Pro His Ala Gly Asn Arg Glu Leu Met Ser Ala Ala Gln Asp His Ile 
        515                 520                 525             


His Arg Asn Asp Ile Leu Gly Glu Trp Thr Tyr Glu Thr Val Ala Gln 
    530                 535                 540                 


Glu Glu Pro Leu Ser Ala His Ser Val Gly Val Ser Ser Val Ala Gly 
545                 550                 555                 560 


Thr Ser His Ala Val Ser Gly Ser Ser Arg Tyr Asp Ser Asn Glu Leu 
                565                 570                 575     


Asp Pro Ser Leu Ser Gly Glu Ile Thr Ala Ser Leu Cys Lys Met Leu 
            580                 585                 590         


Thr His Ala Glu Ala Gln Arg Thr Gly Asp Ser Lys Glu Arg Gly Gly 
        595                 600                 605             


Thr Glu Gln Ser Leu Trp Asp Ser Gln Met Glu Phe Ser Lys Glu Arg 
    610                 615                 620                 


Gln Val Ser Ser Ser Ile Asp Leu Leu Ser Ile Gln Gln Pro Arg Leu 
625                 630                 635                 640 


Ser Gly Ala Arg Ala Glu Glu Ala Leu Ser Ala His Tyr Ser Glu Val 
                645                 650                 655     


Pro Tyr Gly Asp Pro Arg Asp Thr Gly Pro Ser Val Phe Pro Pro Arg 
            660                 665                 670         


Trp Asp Ser Gly Leu Asp Val Thr Pro Ala Asn Lys Glu Pro Val Gln 
        675                 680                 685             


Lys Ser Thr Pro Ser Asp Thr Cys Cys Glu Leu Glu Ser Asp Cys Asp 
    690                 695                 700                 


Ser Asp Glu Gly Ser Leu Phe Thr Leu Ser Ser Ile Ser Ser Glu Ser 
705                 710                 715                 720 


Ala Arg Ser Lys Thr Glu Glu Ala Val Pro Asp Glu Glu Ser Leu Gln 
                725                 730                 735     


Asp Glu Ser Ser Gly Ala Ser Lys Asp Asn Val Thr Ala Val Asp Ser 
            740                 745                 750         


Leu Glu Glu Asn Val Thr Phe Gln Thr Ile Pro Gly Lys Cys Lys Asn 
        755                 760                 765             


Gln Glu Asp Pro Phe Glu Lys Pro Leu Ile Ser Ala Pro Asp Ser Gly 
    770                 775                 780                 


Met Tyr Lys Thr His Leu Glu Asn Ala Ser Asp Thr Asp Arg Ser Glu 
785                 790                 795                 800 


Gly Leu Ser Pro Trp Pro Arg Ser Pro Gly Asn Ser Pro Leu Gly Asp 
                805                 810                 815     


Glu Phe Pro Gly Met Phe Thr Tyr Asp Tyr Asp Thr Ala Leu Gln Ser 
            820                 825                 830         


Lys Ala Ala Glu Trp His Cys Ser Leu Arg Asp Leu Glu Phe Ser Asn 
        835                 840                 845             


Val Asp Val Leu Gln Gln Thr Pro Pro Cys Ser Ala Glu Val Pro Ser 
    850                 855                 860                 


Asp Pro Asp Lys Ala Ala Phe His Glu Arg Asp Ser Asp Ile Leu Lys 
865                 870                 875                 880 


<210>  680
<211>  644
<212>  PRT
<213>  Homo sapiens

<400>  680

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Gly Ile Lys 
                


<210>  681
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  681

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Gly Gly Thr Thr Val Leu 
            580                 585                 590         


Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln Ser Gly Ile 
        595                 600                 605             


Lys 
    


<210>  682
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  682

Met Glu Ser Ser Gly Asn Pro Glu Ser Thr Thr Phe Phe Tyr Tyr Asp 
1               5                   10                  15      


Leu Gln Ser Gln Pro Cys Glu Asn Gln Ala Trp Val Phe Ala Thr Leu 
            20                  25                  30          


Ala Thr Thr Val Leu Tyr Cys Leu Val Phe Leu Leu Ser Leu Val Gly 
        35                  40                  45              


Asn Ser Leu Val Leu Trp Val Leu Val Lys Tyr Glu Ser Leu Glu Ser 
    50                  55                  60                  


Leu Thr Asn Ile Phe Ile Leu Asn Leu Cys Leu Ser Asp Leu Val Phe 
65                  70                  75                  80  


Ala Cys Leu Leu Pro Val Trp Ile Ser Pro Tyr His Trp Gly Trp Val 
                85                  90                  95      


Leu Gly Asp Phe Leu Cys Lys Leu Leu Asn Met Ile Phe Ser Ile Ser 
            100                 105                 110         


Leu Tyr Ser Ser Ile Phe Phe Leu Thr Ile Met Thr Ile His Arg Tyr 
        115                 120                 125             


Leu Ser Val Val Ser Pro Leu Ser Thr Leu Arg Val Pro Thr Leu Arg 
    130                 135                 140                 


Cys Arg Val Leu Val Thr Met Ala Val Trp Val Ala Ser Ile Leu Ser 
145                 150                 155                 160 


Ser Ile Leu Asp Thr Ile Phe His Lys Val Leu Ser Ser Gly Cys Asp 
                165                 170                 175     


Tyr Ser Glu Leu Thr Trp Tyr Leu Thr Ser Val Tyr Gln His Asn Leu 
            180                 185                 190         


Phe Phe Leu Leu Ser Leu Gly Ile Ile Leu Phe Cys Tyr Val Glu Ile 
        195                 200                 205             


Leu Arg Thr Leu Phe Arg Ser Arg Ser Lys Arg Arg His Arg Thr Val 
    210                 215                 220                 


Lys Leu Ile Phe Ala Ile Val Val Ala Tyr Phe Leu Ser Trp Gly Pro 
225                 230                 235                 240 


Tyr Asn Phe Thr Leu Phe Leu Gln Thr Leu Phe Arg Thr Gln Ile Ile 
                245                 250                 255     


Arg Ser Cys Glu Ala Lys Gln Gln Leu Glu Tyr Ala Leu Leu Ile Cys 
            260                 265                 270         


Arg Asn Leu Ala Phe Ser His Cys Cys Phe Asn Pro Val Leu Tyr Val 
        275                 280                 285             


Phe Val Gly Val Lys Phe Arg Thr His Leu Lys His Val Leu Arg Gln 
    290                 295                 300                 


Phe Trp Phe Cys Arg Leu Gln Ala Pro Ser Pro Ala Ser Ile Pro His 
305                 310                 315                 320 


Ser Pro Gly Ala Phe Ala Tyr Glu Gly Ala Ser Phe Tyr 
                325                 330             


<210>  683
<211>  592
<212>  PRT
<213>  Homo sapiens

<400>  683

Met Glu Gly Lys Trp Leu Leu Cys Met Leu Leu Val Leu Gly Thr Ala 
1               5                   10                  15      


Ile Val Glu Ala His Asp Gly His Asp Asp Asp Val Ile Asp Ile Glu 
            20                  25                  30          


Asp Asp Leu Asp Asp Val Ile Glu Glu Val Glu Asp Ser Lys Pro Asp 
        35                  40                  45              


Thr Thr Ala Pro Pro Ser Ser Pro Lys Val Thr Tyr Lys Ala Pro Val 
    50                  55                  60                  


Pro Thr Gly Glu Val Tyr Phe Ala Asp Ser Phe Asp Arg Gly Thr Leu 
65                  70                  75                  80  


Ser Gly Trp Ile Leu Ser Lys Ala Lys Lys Asp Asp Thr Asp Asp Glu 
                85                  90                  95      


Ile Ala Lys Tyr Asp Gly Lys Trp Glu Val Glu Glu Met Lys Glu Ser 
            100                 105                 110         


Lys Leu Pro Gly Asp Lys Gly Leu Val Leu Met Ser Arg Ala Lys His 
        115                 120                 125             


His Ala Ile Ser Ala Lys Leu Asn Lys Pro Phe Leu Phe Asp Thr Lys 
    130                 135                 140                 


Pro Leu Ile Val Gln Tyr Glu Val Asn Phe Gln Asn Gly Ile Glu Cys 
145                 150                 155                 160 


Gly Gly Ala Tyr Val Lys Leu Leu Ser Lys Thr Pro Glu Leu Asn Leu 
                165                 170                 175     


Asp Gln Phe His Asp Lys Thr Pro Tyr Thr Ile Met Phe Gly Pro Asp 
            180                 185                 190         


Lys Cys Gly Glu Asp Tyr Lys Leu His Phe Ile Phe Arg His Lys Asn 
        195                 200                 205             


Pro Lys Thr Gly Ile Tyr Glu Glu Lys His Ala Lys Arg Pro Asp Ala 
    210                 215                 220                 


Asp Leu Lys Thr Tyr Phe Thr Asp Lys Lys Thr His Leu Tyr Thr Leu 
225                 230                 235                 240 


Ile Leu Asn Pro Asp Asn Ser Phe Glu Ile Leu Val Asp Gln Ser Val 
                245                 250                 255     


Val Asn Ser Gly Asn Leu Leu Asn Asp Met Thr Pro Pro Val Asn Pro 
            260                 265                 270         


Ser Arg Glu Ile Glu Asp Pro Glu Asp Arg Lys Pro Glu Asp Trp Asp 
        275                 280                 285             


Glu Arg Pro Lys Ile Pro Asp Pro Glu Ala Val Lys Pro Asp Asp Trp 
    290                 295                 300                 


Asp Glu Asp Ala Pro Ala Lys Ile Pro Asp Glu Glu Ala Thr Lys Pro 
305                 310                 315                 320 


Glu Gly Trp Leu Asp Asp Glu Pro Glu Tyr Val Pro Asp Pro Asp Ala 
                325                 330                 335     


Glu Lys Pro Glu Asp Trp Asp Glu Asp Met Asp Gly Glu Trp Glu Ala 
            340                 345                 350         


Pro Gln Ile Ala Asn Pro Arg Cys Glu Ser Ala Pro Gly Cys Gly Val 
        355                 360                 365             


Trp Gln Arg Pro Val Ile Asp Asn Pro Asn Tyr Lys Gly Lys Trp Lys 
    370                 375                 380                 


Pro Pro Met Ile Asp Asn Pro Ser Tyr Gln Gly Ile Trp Lys Pro Arg 
385                 390                 395                 400 


Lys Ile Pro Asn Pro Asp Phe Phe Glu Asp Leu Glu Pro Phe Arg Met 
                405                 410                 415     


Thr Pro Phe Ser Ala Ile Gly Leu Glu Leu Trp Ser Met Thr Ser Asp 
            420                 425                 430         


Ile Phe Phe Asp Asn Phe Ile Ile Cys Ala Asp Arg Arg Ile Val Asp 
        435                 440                 445             


Asp Trp Ala Asn Asp Gly Trp Gly Leu Lys Lys Ala Ala Asp Gly Ala 
    450                 455                 460                 


Ala Glu Pro Gly Val Val Gly Gln Met Ile Glu Ala Ala Glu Glu Arg 
465                 470                 475                 480 


Pro Trp Leu Trp Val Val Tyr Ile Leu Thr Val Ala Leu Pro Val Phe 
                485                 490                 495     


Leu Val Ile Leu Phe Cys Cys Ser Gly Lys Lys Gln Thr Ser Gly Met 
            500                 505                 510         


Glu Tyr Lys Lys Thr Asp Ala Pro Gln Pro Asp Val Lys Glu Glu Glu 
        515                 520                 525             


Glu Glu Lys Glu Glu Glu Lys Asp Lys Gly Asp Glu Glu Glu Glu Gly 
    530                 535                 540                 


Glu Glu Lys Leu Glu Glu Lys Gln Lys Ser Asp Ala Glu Glu Asp Gly 
545                 550                 555                 560 


Gly Thr Val Ser Gln Glu Glu Glu Asp Arg Lys Pro Lys Ala Glu Glu 
                565                 570                 575     


Asp Glu Ile Leu Asn Arg Ser Pro Arg Asn Arg Lys Pro Arg Arg Glu 
            580                 585                 590         


<210>  684
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  684

Met Ala Leu Ser Arg Val Cys Trp Ala Arg Ser Ala Val Trp Gly Ser 
1               5                   10                  15      


Ala Val Thr Pro Gly His Phe Val Thr Arg Arg Leu Gln Leu Gly Arg 
            20                  25                  30          


Ser Gly Leu Ala Trp Gly Ala Pro Arg Ser Ser Lys Leu His Leu Ser 
        35                  40                  45              


Pro Lys Ala Asp Val Lys Asn Leu Met Ser Tyr Val Val Thr Lys Thr 
    50                  55                  60                  


Lys Ala Ile Asn Gly Lys Tyr His Arg Phe Leu Gly Arg His Phe Pro 
65                  70                  75                  80  


Arg Phe Tyr Val Leu Tyr Thr Ile Phe Met Lys Gly Leu Gln Met Leu 
                85                  90                  95      


Trp Ala Asp Ala Lys Lys Ala Arg Arg Ile Lys Thr Asn Met Trp Lys 
            100                 105                 110         


His Asn Ile Lys Phe His Gln Leu Pro Tyr Arg Glu Met Glu His Leu 
        115                 120                 125             


Arg Gln Val Trp Ala Arg Gly Arg Tyr Pro Glu Val His Gly Glu Phe 
    130                 135                 140                 


Arg Gln Asp Val Thr Lys Cys Leu Phe Leu Gly Ile Ile Ser Ile Pro 
145                 150                 155                 160 


Pro Phe Ala Asn Tyr Leu Val Phe Leu Leu Met Tyr Leu Phe Pro Arg 
                165                 170                 175     


Gln Leu Leu Ile Arg His Phe Trp Thr Pro Lys Gln Gln Thr Asp Phe 
            180                 185                 190         


Leu Asp Ile Tyr His Ala Phe Arg Lys Gln Ser His Pro Glu Ile Ile 
        195                 200                 205             


Ser Tyr Leu Glu Lys Val Ile Pro Leu Ile Ser Asp Ala Gly Leu Arg 
    210                 215                 220                 


Trp Arg Leu Thr Asp Leu Cys Thr Lys Ile Gln Arg Gly Thr His Pro 
225                 230                 235                 240 


Ala Ile His Asp Ile Leu Ala Leu Arg Glu Cys Phe Ser Asn His Pro 
                245                 250                 255     


Leu Gly Met Asn Gln Leu Gln Ala Leu His Val Lys Ala Leu Ser Arg 
            260                 265                 270         


Ala Met Leu Leu Thr Ser Tyr Leu Pro Pro Pro Leu Leu Arg His Arg 
        275                 280                 285             


Leu Lys Thr His Thr Thr Val Ile His Gln Leu Asp Lys Ala Leu Ala 
    290                 295                 300                 


Lys Leu Gly Ile Gly Gln Leu Thr Ala Gln Glu Val Lys Ser Ala Cys 
305                 310                 315                 320 


Tyr Leu Arg Gly Leu Asn Ser Thr His Ile Gly Glu Asp Arg Cys Arg 
                325                 330                 335     


Thr Trp Leu Gly Glu Trp Leu Gln Ile Ser Cys Ser Leu Lys Glu Ala 
            340                 345                 350         


Glu Leu Ser Leu Leu Leu His Asn Val Val Leu Leu Ser Thr Asn Tyr 
        355                 360                 365             


Leu Gly Thr Arg Arg 
    370             


<210>  685
<211>  534
<212>  PRT
<213>  Homo sapiens

<400>  685

Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 
1               5                   10                  15      


Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln 
            20                  25                  30          


Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu 
        35                  40                  45              


Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 
    50                  55                  60                  


Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala 
65                  70                  75                  80  


Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe 
                85                  90                  95      


Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 
            100                 105                 110         


Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp 
        115                 120                 125             


Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys 
    130                 135                 140                 


Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr 
145                 150                 155                 160 


Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val 
                165                 170                 175     


Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr 
            180                 185                 190         


Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Ile Leu 
        195                 200                 205             


Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn 
    210                 215                 220                 


Pro Val Leu Gln Gln Asp Ala His Ser Ser Val Thr Ile Thr Pro Gln 
225                 230                 235                 240 


Arg Ser Pro Thr Gly Ala Val Glu Val Gln Val Pro Glu Asp Pro Val 
                245                 250                 255     


Val Ala Leu Val Gly Thr Asp Ala Thr Leu Arg Cys Ser Phe Ser Pro 
            260                 265                 270         


Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr 
        275                 280                 285             


Asp Thr Lys Gln Leu Val His Ser Phe Thr Glu Gly Arg Asp Gln Gly 
    290                 295                 300                 


Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln 
305                 310                 315                 320 


Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val Ala Asp Glu Gly 
                325                 330                 335     


Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly Ser Ala Ala Val 
            340                 345                 350         


Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu 
        355                 360                 365             


Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr Ile Thr Cys Ser 
    370                 375                 380                 


Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp Gln Asp Gly Gln 
385                 390                 395                 400 


Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln Met Ala Asn Glu 
                405                 410                 415     


Gln Gly Leu Phe Asp Val His Ser Val Leu Arg Val Val Leu Gly Ala 
            420                 425                 430         


Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val Leu Gln Gln Asp 
        435                 440                 445             


Ala His Gly Ser Val Thr Ile Thr Gly Gln Pro Met Thr Phe Pro Pro 
    450                 455                 460                 


Glu Ala Leu Trp Val Thr Val Gly Leu Ser Val Cys Leu Ile Ala Leu 
465                 470                 475                 480 


Leu Val Ala Leu Ala Phe Val Cys Trp Arg Lys Ile Lys Gln Ser Cys 
                485                 490                 495     


Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln Asp Gly Glu Gly Glu Gly 
            500                 505                 510         


Ser Lys Thr Ala Leu Gln Pro Leu Lys His Ser Asp Ser Lys Glu Asp 
        515                 520                 525             


Asp Gly Gln Glu Ile Ala 
    530                 


<210>  686
<211>  651
<212>  PRT
<213>  Homo sapiens

<400>  686

Met Gly Pro Ala Ser Pro Ala Ala Arg Gly Leu Ser Arg Arg Pro Gly 
1               5                   10                  15      


Gln Pro Pro Leu Pro Leu Leu Leu Pro Leu Leu Leu Leu Leu Leu Arg 
            20                  25                  30          


Ala Gln Pro Ala Ile Gly Ser Leu Ala Gly Gly Ser Pro Gly Ala Ala 
        35                  40                  45              


Glu Ala Pro Gly Ser Ala Gln Val Ala Gly Leu Cys Gly Arg Leu Thr 
    50                  55                  60                  


Leu His Arg Asp Leu Arg Thr Gly Arg Trp Glu Pro Asp Pro Gln Arg 
65                  70                  75                  80  


Ser Arg Arg Cys Leu Arg Asp Pro Gln Arg Val Leu Glu Tyr Cys Arg 
                85                  90                  95      


Gln Met Tyr Pro Glu Leu Gln Ile Ala Arg Val Glu Gln Ala Thr Gln 
            100                 105                 110         


Ala Ile Pro Met Glu Arg Trp Cys Gly Gly Ser Arg Ser Gly Ser Cys 
        115                 120                 125             


Ala His Pro His His Gln Val Val Pro Phe Arg Cys Leu Pro Gly Glu 
    130                 135                 140                 


Phe Val Ser Glu Ala Leu Leu Val Pro Glu Gly Cys Arg Phe Leu His 
145                 150                 155                 160 


Gln Glu Arg Met Asp Gln Cys Glu Ser Ser Thr Arg Arg His Gln Glu 
                165                 170                 175     


Ala Gln Glu Ala Cys Ser Ser Gln Gly Leu Ile Leu His Gly Ser Gly 
            180                 185                 190         


Met Leu Leu Pro Cys Gly Ser Asp Arg Phe Arg Gly Val Glu Tyr Val 
        195                 200                 205             


Cys Cys Pro Pro Pro Gly Thr Pro Asp Pro Ser Gly Thr Ala Val Gly 
    210                 215                 220                 


Asp Pro Ser Thr Arg Ser Trp Pro Pro Gly Ser Arg Val Glu Gly Ala 
225                 230                 235                 240 


Glu Asp Glu Glu Glu Glu Glu Ser Phe Pro Gln Pro Val Asp Asp Tyr 
                245                 250                 255     


Phe Val Glu Pro Pro Gln Ala Glu Glu Glu Glu Glu Thr Val Pro Pro 
            260                 265                 270         


Pro Ser Ser His Thr Leu Ala Val Val Gly Lys Val Thr Pro Thr Pro 
        275                 280                 285             


Arg Pro Thr Asp Gly Val Asp Ile Tyr Phe Gly Met Pro Gly Glu Ile 
    290                 295                 300                 


Ser Glu His Glu Gly Phe Leu Arg Ala Lys Met Asp Leu Glu Glu Arg 
305                 310                 315                 320 


Arg Met Arg Gln Ile Asn Glu Val Met Arg Glu Trp Ala Met Ala Asp 
                325                 330                 335     


Asn Gln Ser Lys Asn Leu Pro Lys Ala Asp Arg Gln Ala Leu Asn Glu 
            340                 345                 350         


His Phe Gln Ser Ile Leu Gln Thr Leu Glu Glu Gln Val Ser Gly Glu 
        355                 360                 365             


Arg Gln Arg Leu Val Glu Thr His Ala Thr Arg Val Ile Ala Leu Ile 
    370                 375                 380                 


Asn Asp Gln Arg Arg Ala Ala Leu Glu Gly Phe Leu Ala Ala Leu Gln 
385                 390                 395                 400 


Ala Asp Pro Pro Gln Ala Glu Arg Val Leu Leu Ala Leu Arg Arg Tyr 
                405                 410                 415     


Leu Arg Ala Glu Gln Lys Glu Gln Arg His Thr Leu Arg His Tyr Gln 
            420                 425                 430         


His Val Ala Ala Val Asp Pro Glu Lys Ala Gln Gln Met Arg Phe Gln 
        435                 440                 445             


Val His Thr His Leu Gln Val Ile Glu Glu Arg Val Asn Gln Ser Leu 
    450                 455                 460                 


Gly Leu Leu Asp Gln Asn Pro His Leu Ala Gln Glu Leu Arg Pro Gln 
465                 470                 475                 480 


Ile Gln Glu Leu Leu His Ser Glu His Leu Gly Pro Ser Glu Leu Glu 
                485                 490                 495     


Ala Pro Ala Pro Gly Gly Ser Ser Glu Asp Lys Gly Gly Leu Gln Pro 
            500                 505                 510         


Pro Asp Ser Lys Asp Ala Asp Thr Pro Met Thr Leu Pro Lys Gly Ser 
        515                 520                 525             


Thr Glu Gln Asp Ala Ala Ser Pro Glu Lys Glu Lys Met Asn Pro Leu 
    530                 535                 540                 


Glu Gln Tyr Glu Arg Lys Val Asn Ala Ser Val Pro Arg Gly Phe Pro 
545                 550                 555                 560 


Phe His Ser Ser Glu Ile Gln Arg Asp Glu Leu Ala Pro Ala Gly Thr 
                565                 570                 575     


Gly Val Ser Arg Glu Ala Val Ser Gly Leu Leu Ile Met Gly Ala Gly 
            580                 585                 590         


Gly Gly Ser Leu Ile Val Leu Ser Met Leu Leu Leu Arg Arg Lys Lys 
        595                 600                 605             


Pro Tyr Gly Ala Ile Ser His Gly Val Val Glu Val Asp Pro Met Leu 
    610                 615                 620                 


Thr Leu Glu Glu Gln Gln Leu Arg Glu Leu Gln Arg His Gly Tyr Glu 
625                 630                 635                 640 


Asn Pro Thr Tyr Arg Phe Leu Glu Glu Arg Pro 
                645                 650     


<210>  687
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  687

Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe 
1               5                   10                  15      


Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val 
            20                  25                  30          


Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser 
        35                  40                  45              


Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala 
    50                  55                  60                  


Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu 
65                  70                  75                  80  


Val Arg Cys Leu Leu Gly Leu Leu Lys Gln Glu Met Gly Gly Ile Val 
                85                  90                  95      


Thr Glu Leu Ile Arg Asp Tyr Asn Ser Ser Arg Glu Asp Ser Leu Gln 
            100                 105                 110         


Asp Ala Trp Asp Tyr Val Gln Ala Gln Val Lys Cys Cys Gly Trp Val 
        115                 120                 125             


Ser Phe Tyr Asn Trp Thr Asp Asn Ala Glu Leu Met Asn Arg Pro Glu 
    130                 135                 140                 


Val Thr Tyr Pro Cys Ser Cys Glu Val Lys Gly Glu Glu Asp Asn Ser 
145                 150                 155                 160 


Leu Ser Val Arg Lys Gly Phe Cys Glu Ala Pro Gly Asn Arg Thr Gln 
                165                 170                 175     


Ser Gly Asn His Pro Glu Asp Trp Pro Val Tyr Gln Glu Gly Cys Met 
            180                 185                 190         


Glu Lys Val Gln Ala Trp Leu Gln Glu Asn Leu Gly Ile Ile Leu Gly 
        195                 200                 205             


Val Gly Val Gly Val Ala Ile Ile Glu Leu Leu Gly Met Val Leu Ser 
    210                 215                 220                 


Ile Cys Leu Cys Arg His Val His Ser Glu Asp Tyr Ser Lys Val Pro 
225                 230                 235                 240 


Lys Tyr 
        


<210>  688
<211>  633
<212>  PRT
<213>  Homo sapiens

<400>  688

Met Val Gly Lys Gly Ala Lys Gly Met Leu Asn Gly Ala Val Pro Ser 
1               5                   10                  15      


Glu Ala Thr Lys Arg Asp Gln Asn Leu Lys Arg Gly Asn Trp Gly Asn 
            20                  25                  30          


Gln Ile Glu Phe Val Leu Thr Ser Val Gly Tyr Ala Val Gly Leu Gly 
        35                  40                  45              


Asn Val Trp Arg Phe Pro Tyr Leu Cys Tyr Arg Asn Gly Gly Gly Ala 
    50                  55                  60                  


Phe Met Phe Pro Tyr Phe Ile Met Leu Ile Phe Cys Gly Ile Pro Leu 
65                  70                  75                  80  


Phe Phe Met Glu Leu Ser Phe Gly Gln Phe Ala Ser Gln Gly Cys Leu 
                85                  90                  95      


Gly Val Trp Arg Ile Ser Pro Met Phe Lys Gly Val Gly Tyr Gly Met 
            100                 105                 110         


Met Val Val Ser Thr Tyr Ile Gly Ile Tyr Tyr Asn Val Val Ile Cys 
        115                 120                 125             


Ile Ala Phe Tyr Tyr Phe Phe Ser Ser Met Thr His Val Leu Pro Trp 
    130                 135                 140                 


Ala Tyr Cys Asn Asn Pro Trp Asn Thr His Asp Cys Ala Gly Val Leu 
145                 150                 155                 160 


Asp Ala Ser Asn Leu Thr Asn Gly Ser Arg Pro Ala Ala Leu Pro Ser 
                165                 170                 175     


Asn Leu Ser His Leu Leu Asn His Ser Leu Gln Arg Thr Ser Pro Ser 
            180                 185                 190         


Glu Glu Tyr Trp Arg Leu Tyr Val Leu Lys Leu Ser Asp Asp Ile Gly 
        195                 200                 205             


Asn Phe Gly Glu Val Arg Leu Pro Leu Leu Gly Cys Leu Gly Val Ser 
    210                 215                 220                 


Trp Leu Val Val Phe Leu Cys Leu Ile Arg Gly Val Lys Ser Ser Gly 
225                 230                 235                 240 


Lys Val Val Tyr Phe Thr Ala Thr Phe Pro Tyr Val Val Leu Thr Ile 
                245                 250                 255     


Leu Phe Val Arg Gly Val Thr Leu Glu Gly Ala Phe Asp Gly Ile Met 
            260                 265                 270         


Tyr Tyr Leu Thr Pro Gln Trp Asp Lys Ile Leu Glu Ala Lys Val Trp 
        275                 280                 285             


Gly Asp Ala Ala Ser Gln Ile Phe Tyr Ser Leu Gly Cys Ala Trp Gly 
    290                 295                 300                 


Gly Leu Ile Thr Met Ala Ser Tyr Asn Lys Phe His Asn Asn Cys Tyr 
305                 310                 315                 320 


Arg Asp Ser Val Ile Ile Ser Ile Thr Asn Cys Ala Thr Ser Val Tyr 
                325                 330                 335     


Ala Gly Phe Val Ile Phe Ser Ile Leu Gly Phe Met Ala Asn His Leu 
            340                 345                 350         


Gly Val Asp Val Ser Arg Val Ala Asp His Gly Pro Gly Leu Ala Phe 
        355                 360                 365             


Val Ala Tyr Pro Glu Ala Leu Thr Leu Leu Pro Ile Ser Pro Leu Trp 
    370                 375                 380                 


Ser Leu Leu Phe Phe Phe Met Leu Ile Leu Leu Gly Leu Gly Thr Gln 
385                 390                 395                 400 


Phe Cys Leu Leu Glu Thr Leu Val Thr Ala Ile Val Asp Glu Val Gly 
                405                 410                 415     


Asn Glu Trp Ile Leu Gln Lys Lys Thr Tyr Val Thr Leu Gly Val Ala 
            420                 425                 430         


Val Ala Gly Phe Leu Leu Gly Ile Pro Leu Thr Ser Gln Ala Gly Ile 
        435                 440                 445             


Tyr Trp Leu Leu Leu Met Asp Asn Tyr Ala Ala Ser Phe Ser Leu Val 
    450                 455                 460                 


Val Ile Ser Cys Ile Met Cys Val Ala Ile Met Tyr Ile Tyr Gly His 
465                 470                 475                 480 


Arg Asn Tyr Phe Gln Asp Ile Gln Met Met Leu Gly Phe Pro Pro Pro 
                485                 490                 495     


Leu Phe Phe Gln Ile Cys Trp Arg Phe Val Ser Pro Ala Ile Ile Phe 
            500                 505                 510         


Phe Ile Leu Val Phe Thr Val Ile Gln Tyr Gln Pro Ile Thr Tyr Asn 
        515                 520                 525             


His Tyr Gln Tyr Pro Gly Trp Ala Val Ala Ile Gly Phe Leu Met Ala 
    530                 535                 540                 


Leu Ser Ser Val Leu Cys Ile Pro Leu Tyr Ala Met Phe Arg Leu Cys 
545                 550                 555                 560 


Arg Thr Asp Gly Asp Thr Leu Leu Gln Arg Leu Lys Asn Ala Thr Lys 
                565                 570                 575     


Pro Ser Arg Asp Trp Gly Pro Ala Leu Leu Glu His Arg Thr Gly Arg 
            580                 585                 590         


Tyr Ala Pro Thr Ile Ala Pro Ser Pro Glu Asp Gly Phe Glu Val Gln 
        595                 600                 605             


Pro Leu His Pro Asp Lys Ala Gln Ile Pro Ile Val Gly Ser Asn Gly 
    610                 615                 620                 


Ser Ser Arg Leu Gln Asp Ser Arg Ile 
625                 630             


<210>  689
<211>  592
<212>  PRT
<213>  Homo sapiens

<400>  689

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Asp 
            20                  25                  30          


Val Glu Met Glu Ala Gln Lys Asp Glu Ile Ile Cys Pro Ser Cys Asn 
        35                  40                  45              


Arg Thr Ala His Pro Leu Arg His Ile Asn Asn Asp Met Ile Val Thr 
    50                  55                  60                  


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
65                  70                  75                  80  


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
                85                  90                  95      


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
            100                 105                 110         


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
        115                 120                 125             


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
    130                 135                 140                 


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
145                 150                 155                 160 


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
                165                 170                 175     


Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln Val 
            180                 185                 190         


Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val Ile 
        195                 200                 205             


Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu Ser Ser 
    210                 215                 220                 


Thr Trp Glu Thr Gly Lys Thr Arg Lys Leu Met Glu Phe Ser Glu His 
225                 230                 235                 240 


Cys Ala Ile Ile Leu Glu Asp Asp Arg Ser Asp Ile Ser Ser Thr Cys 
                245                 250                 255     


Ala Asn Asn Ile Asn His Asn Thr Glu Leu Leu Pro Ile Glu Leu Asp 
            260                 265                 270         


Thr Leu Val Gly Lys Gly Arg Phe Ala Glu Val Tyr Lys Ala Lys Leu 
        275                 280                 285             


Lys Gln Asn Thr Ser Glu Gln Phe Glu Thr Val Ala Val Lys Ile Phe 
    290                 295                 300                 


Pro Tyr Glu Glu Tyr Ala Ser Trp Lys Thr Glu Lys Asp Ile Phe Ser 
305                 310                 315                 320 


Asp Ile Asn Leu Lys His Glu Asn Ile Leu Gln Phe Leu Thr Ala Glu 
                325                 330                 335     


Glu Arg Lys Thr Glu Leu Gly Lys Gln Tyr Trp Leu Ile Thr Ala Phe 
            340                 345                 350         


His Ala Lys Gly Asn Leu Gln Glu Tyr Leu Thr Arg His Val Ile Ser 
        355                 360                 365             


Trp Glu Asp Leu Arg Lys Leu Gly Ser Ser Leu Ala Arg Gly Ile Ala 
    370                 375                 380                 


His Leu His Ser Asp His Thr Pro Cys Gly Arg Pro Lys Met Pro Ile 
385                 390                 395                 400 


Val His Arg Asp Leu Lys Ser Ser Asn Ile Leu Val Lys Asn Asp Leu 
                405                 410                 415     


Thr Cys Cys Leu Cys Asp Phe Gly Leu Ser Leu Arg Leu Asp Pro Thr 
            420                 425                 430         


Leu Ser Val Asp Asp Leu Ala Asn Ser Gly Gln Val Gly Thr Ala Arg 
        435                 440                 445             


Tyr Met Ala Pro Glu Val Leu Glu Ser Arg Met Asn Leu Glu Asn Val 
    450                 455                 460                 


Glu Ser Phe Lys Gln Thr Asp Val Tyr Ser Met Ala Leu Val Leu Trp 
465                 470                 475                 480 


Glu Met Thr Ser Arg Cys Asn Ala Val Gly Glu Val Lys Asp Tyr Glu 
                485                 490                 495     


Pro Pro Phe Gly Ser Lys Val Arg Glu His Pro Cys Val Glu Ser Met 
            500                 505                 510         


Lys Asp Asn Val Leu Arg Asp Arg Gly Arg Pro Glu Ile Pro Ser Phe 
        515                 520                 525             


Trp Leu Asn His Gln Gly Ile Gln Met Val Cys Glu Thr Leu Thr Glu 
    530                 535                 540                 


Cys Trp Asp His Asp Pro Glu Ala Arg Leu Thr Ala Gln Cys Val Ala 
545                 550                 555                 560 


Glu Arg Phe Ser Glu Leu Glu His Leu Asp Arg Leu Ser Gly Arg Ser 
                565                 570                 575     


Cys Ser Glu Glu Lys Ile Pro Glu Asp Gly Ser Leu Asn Thr Thr Lys 
            580                 585                 590         


<210>  690
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  690

Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu 
305                 310                 315                 320 


Leu Ser Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr 
                325                 330                 335     


Val Thr Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp 
            340                 345                 350         


Thr Gly Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser 
        355                 360                 365             


Ser Glu Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn 
    370                 375                 380                 


Pro Val Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn 
385                 390                 395                 400 


Pro Ile Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr 
                405                 410                 415     


Asn Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly 
            420                 425                 430         


Ile Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu 
        435                 440                 445             


Ala Cys Phe Leu His Phe Gly Lys Thr Gly Ser Ser Gly Pro Leu Gln 
    450                 455                 460                 


<210>  691
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  691

Met Ser Gly Phe Glu Asn Leu Asn Thr Asp Phe Tyr Gln Thr Ser Tyr 
1               5                   10                  15      


Ser Ile Asp Asp Gln Ser Gln Gln Ser Tyr Asp Tyr Gly Gly Ser Gly 
            20                  25                  30          


Gly Pro Tyr Ser Lys Gln Tyr Ala Gly Tyr Asp Tyr Ser Gln Gln Gly 
        35                  40                  45              


Arg Phe Val Pro Pro Asp Met Met Gln Pro Gln Gln Pro Tyr Thr Gly 
    50                  55                  60                  


Gln Ile Tyr Gln Pro Thr Gln Ala Tyr Thr Pro Ala Ser Pro Gln Pro 
65                  70                  75                  80  


Phe Tyr Gly Asn Asn Phe Glu Asp Glu Pro Pro Leu Leu Glu Glu Leu 
                85                  90                  95      


Gly Ile Asn Phe Asp His Ile Trp Gln Lys Thr Leu Thr Val Leu His 
            100                 105                 110         


Pro Leu Lys Val Ala Asp Gly Ser Ile Met Asn Glu Thr Asp Leu Ala 
        115                 120                 125             


Gly Pro Met Val Phe Cys Leu Ala Phe Gly Ala Thr Leu Leu Leu Ala 
    130                 135                 140                 


Gly Lys Ile Gln Phe Gly Tyr Val Tyr Gly Ile Ser Ala Ile Gly Cys 
145                 150                 155                 160 


Leu Gly Met Phe Cys Leu Leu Asn Leu Met Ser Met Thr Gly Val Ser 
                165                 170                 175     


Phe Gly Cys Val Ala Ser Val Leu Gly Tyr Cys Leu Leu Pro Met Ile 
            180                 185                 190         


Leu Leu Ser Ser Phe Ala Val Ile Phe Ser Leu Gln Gly Met Val Gly 
        195                 200                 205             


Ile Ile Leu Thr Ala Gly Ile Ile Gly Trp Cys Ser Phe Ser Ala Ser 
    210                 215                 220                 


Lys Ile Phe Ile Ser Ala Leu Ala Met Glu Gly Gln Gln Leu Leu Val 
225                 230                 235                 240 


Ala Tyr Pro Cys Ala Leu Leu Tyr Gly Val Phe Ala Leu Ile Ser Val 
                245                 250                 255     


Phe 
    


<210>  692
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  692

Met Asp Leu Val Leu Arg Val Ala Asp Tyr Tyr Phe Phe Thr Pro Tyr 
1               5                   10                  15      


Val Tyr Pro Ala Thr Trp Pro Glu Asp Asp Ile Phe Arg Gln Ala Ile 
            20                  25                  30          


Ser Leu Leu Ile Val Thr Asn Val Gly Ala Tyr Ile Leu Tyr Phe Phe 
        35                  40                  45              


Cys Ala Thr Leu Ser Tyr Tyr Phe Val Phe Asp His Ala Leu Met Lys 
    50                  55                  60                  


His Pro Gln Phe Leu Lys Asn Gln Val Arg Arg Glu Ile Lys Phe Thr 
65                  70                  75                  80  


Val Gln Ala Leu Pro Trp Ile Ser Ile Leu Thr Val Ala Leu Phe Leu 
                85                  90                  95      


Leu Glu Ile Arg Gly Tyr Ser Lys Leu His Asp Asp Leu Gly Glu Phe 
            100                 105                 110         


Pro Tyr Gly Leu Phe Glu Leu Val Val Ser Ile Ile Ser Phe Leu Phe 
        115                 120                 125             


Phe Thr Asp Met Phe Ile Tyr Trp Ile His Arg Gly Leu His His Arg 
    130                 135                 140                 


Leu Val Tyr Lys Arg Leu His Lys Pro His His Ile Trp Lys Ile Pro 
145                 150                 155                 160 


Thr Pro Phe Ala Ser His Ala Phe His Pro Ile Asp Gly Phe Leu Gln 
                165                 170                 175     


Ser Leu Pro Tyr His Ile Tyr Pro Phe Ile Phe Pro Leu His Lys Val 
            180                 185                 190         


Val Tyr Leu Ser Leu Tyr Ile Leu Val Asn Ile Trp Thr Ile Ser Ile 
        195                 200                 205             


His Asp Gly Asp Phe Arg Val Pro Gln Ile Leu Gln Pro Phe Ile Asn 
    210                 215                 220                 


Gly Ser Ala His His Thr Asp His His Met Phe Phe Asp Tyr Asn Tyr 
225                 230                 235                 240 


Gly Gln Tyr Phe Thr Leu Trp Asp Arg Ile Gly Gly Ser Phe Lys Asn 
                245                 250                 255     


Pro Ser Ser Phe Glu Gly Lys Gly Pro Leu Ser Tyr Val Lys Glu Met 
            260                 265                 270         


Thr Glu Gly Lys Arg Ser Ser His Ser Gly Asn Gly Cys Lys Asn Glu 
        275                 280                 285             


Lys Leu Phe Asn Gly Glu Phe Thr Lys Thr Glu 
    290                 295                 


<210>  693
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  693

Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 
    290                 295                 300                 


Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met 
305                 310                 315                 320 


Asn Asp Glu 
            


<210>  694
<211>  485
<212>  PRT
<213>  Homo sapiens

<400>  694

Met Tyr Ile Lys Met Ala Thr Leu Ala Asn Gly Gln Ala Asp Asn Ala 
1               5                   10                  15      


Ser Leu Ser Thr Asn Gly Leu Gly Ser Ser Pro Gly Ser Ala Gly His 
            20                  25                  30          


Met Asn Gly Leu Ser His Ser Pro Gly Asn Pro Ser Thr Ile Pro Met 
        35                  40                  45              


Lys Asp His Asp Ala Ile Lys Leu Phe Ile Gly Gln Ile Pro Arg Asn 
    50                  55                  60                  


Leu Asp Glu Lys Asp Leu Lys Pro Leu Phe Glu Glu Phe Gly Lys Ile 
65                  70                  75                  80  


Tyr Glu Leu Thr Val Leu Lys Asp Arg Phe Thr Gly Met His Lys Gly 
                85                  90                  95      


Cys Ala Phe Leu Thr Tyr Cys Glu Arg Glu Ser Ala Leu Lys Ala Gln 
            100                 105                 110         


Ser Ala Leu His Glu Gln Lys Thr Leu Pro Gly Met Asn Arg Pro Ile 
        115                 120                 125             


Gln Val Lys Pro Ala Asp Ser Glu Ser Arg Gly Gly Ser Ser Cys Leu 
    130                 135                 140                 


Arg Gln Pro Pro Ser Gln Asp Arg Lys Leu Phe Val Gly Met Leu Asn 
145                 150                 155                 160 


Lys Gln Gln Ser Glu Asp Asp Val Arg Arg Leu Phe Glu Ala Phe Gly 
                165                 170                 175     


Asn Ile Glu Glu Cys Thr Ile Leu Arg Gly Pro Asp Gly Asn Ser Lys 
            180                 185                 190         


Gly Cys Ala Phe Val Lys Tyr Ser Ser His Ala Glu Ala Gln Ala Ala 
        195                 200                 205             


Ile Asn Ala Leu His Gly Ser Gln Thr Met Pro Gly Ala Ser Ser Ser 
    210                 215                 220                 


Leu Val Val Lys Phe Ala Asp Thr Asp Lys Glu Arg Thr Met Arg Arg 
225                 230                 235                 240 


Met Gln Gln Met Ala Gly Gln Met Gly Met Phe Asn Pro Met Ala Ile 
                245                 250                 255     


Pro Phe Gly Ala Tyr Gly Ala Tyr Ala Gln Ala Met Gln Gln Gln Ala 
            260                 265                 270         


Ala Leu Met Ala Ser Val Ala Gln Gly Gly Tyr Leu Asn Pro Met Ala 
        275                 280                 285             


Ala Phe Ala Ala Ala Gln Met Gln Gln Met Ala Ala Leu Asn Met Asn 
    290                 295                 300                 


Gly Leu Ala Ala Ala Pro Met Thr Pro Thr Ser Gly Gly Ser Thr Pro 
305                 310                 315                 320 


Pro Gly Ile Thr Ala Pro Ala Val Pro Ser Ile Pro Ser Pro Ile Gly 
                325                 330                 335     


Val Asn Gly Phe Thr Gly Leu Pro Pro Gln Ala Asn Gly Gln Pro Ala 
            340                 345                 350         


Ala Glu Ala Val Phe Ala Asn Gly Ile His Pro Tyr Pro Ala Gln Ser 
        355                 360                 365             


Pro Thr Ala Ala Asp Pro Leu Gln Gln Ala Tyr Ala Gly Val Gln Gln 
    370                 375                 380                 


Tyr Ala Gly Pro Ala Ala Tyr Pro Ala Ala Tyr Gly Gln Ile Ser Gln 
385                 390                 395                 400 


Ala Phe Pro Gln Pro Pro Pro Met Ile Pro Gln Gln Gln Arg Glu Gly 
                405                 410                 415     


Pro Glu Gly Cys Asn Leu Phe Ile Tyr His Leu Pro Gln Glu Phe Gly 
            420                 425                 430         


Asp Ala Glu Leu Met Gln Met Phe Leu Pro Phe Gly Phe Val Ser Phe 
        435                 440                 445             


Asp Asn Pro Ala Ser Ala Gln Thr Ala Ile Gln Ala Met Asn Gly Phe 
    450                 455                 460                 


Gln Ile Gly Met Lys Arg Leu Lys Val Gln Leu Lys Arg Pro Lys Asp 
465                 470                 475                 480 


Ala Asn Arg Pro Tyr 
                485 


<210>  695
<211>  484
<212>  PRT
<213>  Homo sapiens

<400>  695

Met Tyr Ile Lys Met Ala Thr Leu Ala Asn Gly Gln Ala Asp Asn Ala 
1               5                   10                  15      


Ser Leu Ser Thr Asn Gly Leu Gly Ser Ser Pro Gly Ser Ala Gly His 
            20                  25                  30          


Met Asn Gly Leu Ser His Ser Pro Gly Asn Pro Ser Thr Ile Pro Met 
        35                  40                  45              


Lys Asp His Asp Ala Ile Lys Leu Phe Ile Gly Gln Ile Pro Arg Asn 
    50                  55                  60                  


Leu Asp Glu Lys Asp Leu Lys Pro Leu Phe Glu Glu Phe Gly Lys Ile 
65                  70                  75                  80  


Tyr Glu Leu Thr Val Leu Lys Asp Arg Phe Thr Gly Met His Lys Gly 
                85                  90                  95      


Cys Ala Phe Leu Thr Tyr Cys Glu Arg Glu Ser Ala Leu Lys Ala Gln 
            100                 105                 110         


Ser Ala Leu His Glu Gln Lys Thr Leu Pro Gly Met Asn Arg Pro Ile 
        115                 120                 125             


Gln Val Lys Pro Ala Asp Ser Glu Ser Arg Gly Gly Ser Ser Cys Leu 
    130                 135                 140                 


Arg Gln Pro Pro Ser His Arg Lys Leu Phe Val Gly Met Leu Asn Lys 
145                 150                 155                 160 


Gln Gln Ser Glu Asp Asp Val Arg Arg Leu Phe Glu Ala Phe Gly Asn 
                165                 170                 175     


Ile Glu Glu Cys Thr Ile Leu Arg Gly Pro Asp Gly Asn Ser Lys Gly 
            180                 185                 190         


Cys Ala Phe Val Lys Tyr Ser Ser His Ala Glu Ala Gln Ala Ala Ile 
        195                 200                 205             


Asn Ala Leu His Gly Ser Gln Thr Met Pro Gly Ala Ser Ser Ser Leu 
    210                 215                 220                 


Val Val Lys Phe Ala Asp Thr Asp Lys Glu Arg Thr Met Arg Arg Met 
225                 230                 235                 240 


Gln Gln Met Ala Gly Gln Met Gly Met Phe Asn Pro Met Ala Ile Pro 
                245                 250                 255     


Phe Gly Ala Tyr Gly Ala Tyr Ala Gln Ala Met Gln Gln Gln Ala Ala 
            260                 265                 270         


Leu Met Ala Ser Val Ala Gln Gly Gly Tyr Leu Asn Pro Met Ala Ala 
        275                 280                 285             


Phe Ala Ala Ala Gln Met Gln Gln Met Ala Ala Leu Asn Met Asn Gly 
    290                 295                 300                 


Leu Ala Ala Ala Pro Met Thr Pro Thr Ser Gly Gly Ser Thr Pro Pro 
305                 310                 315                 320 


Gly Ile Thr Ala Pro Ala Val Pro Ser Ile Pro Ser Pro Ile Gly Val 
                325                 330                 335     


Asn Gly Phe Thr Gly Leu Pro Pro Gln Ala Asn Gly Gln Pro Ala Ala 
            340                 345                 350         


Glu Ala Val Phe Ala Asn Gly Ile His Pro Tyr Pro Ala Gln Ser Pro 
        355                 360                 365             


Thr Ala Ala Asp Pro Leu Gln Gln Ala Tyr Ala Gly Val Gln Gln Tyr 
    370                 375                 380                 


Ala Gly Pro Ala Ala Tyr Pro Ala Ala Tyr Gly Gln Ile Ser Gln Ala 
385                 390                 395                 400 


Phe Pro Gln Pro Pro Pro Met Ile Pro Gln Gln Gln Arg Glu Gly Pro 
                405                 410                 415     


Glu Gly Cys Asn Leu Phe Ile Tyr His Leu Pro Gln Glu Phe Gly Asp 
            420                 425                 430         


Ala Glu Leu Met Gln Met Phe Leu Pro Phe Gly Phe Val Ser Phe Asp 
        435                 440                 445             


Asn Pro Ala Ser Ala Gln Thr Ala Ile Gln Ala Met Asn Gly Phe Gln 
    450                 455                 460                 


Ile Gly Met Lys Arg Leu Lys Val Gln Leu Lys Arg Pro Lys Asp Ala 
465                 470                 475                 480 


Asn Arg Pro Tyr 
                


<210>  696
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  696

Met Tyr Ile Lys Met Ala Thr Leu Ala Asn Gly Gln Ala Asp Asn Ala 
1               5                   10                  15      


Ser Leu Ser Thr Asn Gly Leu Gly Ser Ser Pro Gly Ser Ala Gly His 
            20                  25                  30          


Met Asn Gly Leu Ser His Ser Pro Gly Asn Pro Ser Thr Ile Pro Met 
        35                  40                  45              


Lys Asp His Asp Ala Ile Lys Leu Phe Ile Gly Gln Ile Pro Arg Asn 
    50                  55                  60                  


Leu Asp Glu Lys Asp Leu Lys Pro Leu Phe Glu Glu Phe Gly Lys Ile 
65                  70                  75                  80  


Tyr Glu Leu Thr Val Leu Lys Asp Arg Phe Thr Gly Met His Lys Gly 
                85                  90                  95      


Cys Ala Phe Leu Thr Tyr Cys Glu Arg Glu Ser Ala Leu Lys Ala Gln 
            100                 105                 110         


Ser Ala Leu His Glu Gln Lys Thr Leu Pro Gly Met Asn Arg Pro Ile 
        115                 120                 125             


Gln Val Lys Pro Ala Asp Ser Glu Ser Arg Gly Glu Asp Arg Lys Leu 
    130                 135                 140                 


Phe Val Gly Met Leu Asn Lys Gln Gln Ser Glu Asp Asp Val Arg Arg 
145                 150                 155                 160 


Leu Phe Glu Ala Phe Gly Asn Ile Glu Glu Cys Thr Ile Leu Arg Gly 
                165                 170                 175     


Pro Asp Gly Asn Ser Lys Gly Cys Ala Phe Val Lys Tyr Ser Ser His 
            180                 185                 190         


Ala Glu Ala Gln Ala Ala Ile Asn Ala Leu His Gly Ser Gln Thr Met 
        195                 200                 205             


Pro Gly Ala Ser Ser Ser Leu Val Val Lys Phe Ala Asp Thr Asp Lys 
    210                 215                 220                 


Glu Arg Thr Met Arg Arg Met Gln Gln Met Ala Gly Gln Met Gly Met 
225                 230                 235                 240 


Phe Asn Pro Met Ala Ile Pro Phe Gly Ala Tyr Gly Ala Tyr Ala Gln 
                245                 250                 255     


Ala Leu Met Gln Gln Gln Ala Ala Leu Met Ala Ser Val Ala Gln Gly 
            260                 265                 270         


Gly Tyr Leu Asn Pro Met Ala Ala Phe Ala Ala Ala Gln Met Gln Gln 
        275                 280                 285             


Met Ala Ala Leu Asn Met Asn Gly Leu Ala Ala Ala Pro Met Thr Pro 
    290                 295                 300                 


Thr Ser Gly Gly Ser Thr Pro Pro Gly Ile Thr Ala Pro Ala Val Pro 
305                 310                 315                 320 


Ser Ile Pro Ser Pro Ile Gly Val Asn Gly Phe Thr Gly Leu Pro Pro 
                325                 330                 335     


Gln Ala Asn Gly Gln Pro Ala Ala Glu Ala Val Phe Ala Asn Gly Ile 
            340                 345                 350         


His Pro Tyr Pro Ala Gln Ser Pro Thr Ala Ala Asp Pro Leu Gln Gln 
        355                 360                 365             


Ala Tyr Ala Gly Val Gln Gln Tyr Ala Gly Pro Ala Ala Tyr Pro Ala 
    370                 375                 380                 


Ala Tyr Gly Gln Ile Ser Gln Ala Phe Pro Gln Pro Pro Pro Met Ile 
385                 390                 395                 400 


Pro Gln Gln Gln Arg Glu Gly Phe Val Ser Phe Asp Asn Pro Ala Ser 
                405                 410                 415     


Ala Gln Thr Ala Ile Gln Ala Met Asn Gly Phe Gln Ile Gly Met Lys 
            420                 425                 430         


Arg Leu Lys Val Gln Leu Lys Arg Pro Lys Asp Ala Asn Arg Pro Tyr 
        435                 440                 445             


<210>  697
<211>  385
<212>  PRT
<213>  Homo sapiens

<400>  697

Met Leu Val Arg Arg Gly Ala Arg Ala Gly Pro Arg Met Pro Arg Gly 
1               5                   10                  15      


Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser Gly Phe Met Ser 
            20                  25                  30          


Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro Thr Gln Gly Thr 
        35                  40                  45              


Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu Thr Thr Thr Pro 
    50                  55                  60                  


Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser Gln His Gly Asn 
65                  70                  75                  80  


Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys Phe Thr Ser Thr 
                85                  90                  95      


Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser Ser Val Gln Ser 
            100                 105                 110         


Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro Ala Asn Val Ser 
        115                 120                 125             


Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro Gly Asn Val Ser 
    130                 135                 140                 


Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser Pro Thr Lys Pro 
145                 150                 155                 160 


Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys Ala Glu Ile Lys 
                165                 170                 175     


Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly Ile Cys Leu Glu 
            180                 185                 190         


Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys Asp Arg Gly Glu 
        195                 200                 205             


Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala Asp Ala Asp Ala 
    210                 215                 220                 


Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser Glu Val Arg Pro 
225                 230                 235                 240 


Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu Ile Ser Ser Lys 
                245                 250                 255     


Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys Lys Leu Gly Ile 
            260                 265                 270         


Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln Ser Tyr Ser Gln 
        275                 280                 285             


Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu Leu Ala Val Leu 
    290                 295                 300                 


Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser Trp Ser Pro Thr 
305                 310                 315                 320 


Gly Glu Arg Leu Gly Glu Asp Pro Tyr Tyr Thr Glu Asn Gly Gly Gly 
                325                 330                 335     


Gln Gly Tyr Ser Ser Gly Pro Gly Thr Ser Pro Glu Ala Gln Gly Lys 
            340                 345                 350         


Ala Ser Val Asn Arg Gly Ala Gln Glu Asn Gly Thr Gly Gln Ala Thr 
        355                 360                 365             


Ser Arg Asn Gly His Ser Ala Arg Gln His Val Val Ala Asp Thr Glu 
    370                 375                 380                 


Leu 
385 


<210>  698
<211>  786
<212>  PRT
<213>  Homo sapiens

<400>  698

Met Gly Gly Arg Val Phe Leu Ala Phe Cys Val Trp Leu Thr Leu Pro 
1               5                   10                  15      


Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp Cys Pro Gln 
            20                  25                  30          


Asn Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn Pro Gly Phe 
        35                  40                  45              


Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Thr Glu Thr Cys Asp Asp 
    50                  55                  60                  


Ile Asn Glu Cys Ala Thr Pro Ser Lys Val Ser Cys Gly Lys Phe Ser 
65                  70                  75                  80  


Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly 
                85                  90                  95      


Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu Ser Glu Asn 
            100                 105                 110         


Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg Leu Cys Lys 
        115                 120                 125             


Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr Cys Gln Cys 
    130                 135                 140                 


Leu Pro Gly Phe Lys Phe Ile Pro Glu Asp Pro Lys Val Cys Thr Asp 
145                 150                 155                 160 


Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp Ser Ser Thr Val 
                165                 170                 175     


Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys Arg Pro Gly Trp 
            180                 185                 190         


Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp Thr Val Cys Glu 
        195                 200                 205             


Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly Val His Ser Gln 
    210                 215                 220                 


Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu Gly Arg Asp Ser 
225                 230                 235                 240 


Lys Thr Ser Ser Ala Glu Val Thr Ile Gln Asn Val Ile Lys Leu Val 
                245                 250                 255     


Asp Glu Leu Met Glu Ala Pro Gly Asp Val Glu Ala Leu Ala Pro Pro 
            260                 265                 270         


Val Arg His Leu Ile Ala Thr Gln Leu Leu Ser Asn Leu Glu Asp Ile 
        275                 280                 285             


Met Arg Ile Leu Ala Lys Ser Leu Pro Lys Gly Pro Phe Thr Tyr Ile 
    290                 295                 300                 


Ser Pro Ser Asn Thr Glu Leu Thr Leu Met Ile Gln Glu Arg Gly Asp 
305                 310                 315                 320 


Lys Asn Val Thr Met Gly Gln Ser Ser Ala Arg Met Lys Leu Asn Trp 
                325                 330                 335     


Ala Val Ala Ala Gly Ala Glu Asp Pro Gly Pro Ala Val Ala Gly Ile 
            340                 345                 350         


Leu Ser Ile Gln Asn Met Thr Thr Leu Leu Ala Asn Ala Ser Leu Asn 
        355                 360                 365             


Leu His Ser Lys Lys Gln Ala Glu Leu Glu Glu Ile Tyr Glu Ser Ser 
    370                 375                 380                 


Ile Arg Gly Val Gln Leu Arg Arg Leu Ser Ala Val Asn Ser Ile Phe 
385                 390                 395                 400 


Leu Ser His Asn Asn Thr Lys Glu Leu Asn Ser Pro Ile Leu Phe Ala 
                405                 410                 415     


Phe Ser His Leu Glu Ser Ser Asp Gly Glu Ala Gly Arg Asp Pro Pro 
            420                 425                 430         


Ala Lys Asp Val Met Pro Gly Pro Arg Gln Glu Leu Leu Cys Ala Phe 
        435                 440                 445             


Trp Lys Ser Asp Ser Asp Arg Gly Gly His Trp Ala Thr Glu Gly Cys 
    450                 455                 460                 


Gln Val Leu Gly Ser Lys Asn Gly Ser Thr Thr Cys Gln Cys Ser His 
465                 470                 475                 480 


Leu Ser Ser Phe Ala Ile Leu Met Ala His Tyr Asp Val Glu Asp Trp 
                485                 490                 495     


Lys Leu Thr Leu Ile Thr Arg Val Gly Leu Ala Leu Ser Leu Phe Cys 
            500                 505                 510         


Leu Leu Leu Cys Ile Leu Thr Phe Leu Leu Val Arg Pro Ile Gln Gly 
        515                 520                 525             


Ser Arg Thr Thr Ile His Leu His Leu Cys Ile Cys Leu Phe Val Gly 
    530                 535                 540                 


Ser Thr Ile Phe Leu Ala Gly Ile Glu Asn Glu Gly Gly Gln Val Gly 
545                 550                 555                 560 


Leu Arg Cys Arg Leu Val Ala Gly Leu Leu His Tyr Cys Phe Leu Ala 
                565                 570                 575     


Ala Phe Cys Trp Met Ser Leu Glu Gly Leu Glu Leu Tyr Phe Leu Val 
            580                 585                 590         


Val Arg Val Phe Gln Gly Gln Gly Leu Ser Thr Arg Trp Leu Cys Leu 
        595                 600                 605             


Ile Gly Tyr Gly Val Pro Leu Leu Ile Val Gly Val Ser Ala Ala Ile 
    610                 615                 620                 


Tyr Ser Lys Gly Tyr Gly Arg Pro Arg Tyr Cys Trp Leu Asp Phe Glu 
625                 630                 635                 640 


Gln Gly Phe Leu Trp Ser Phe Leu Gly Pro Val Thr Phe Ile Ile Leu 
                645                 650                 655     


Cys Asn Ala Val Ile Phe Val Thr Thr Val Trp Lys Leu Thr Gln Lys 
            660                 665                 670         


Phe Ser Glu Ile Asn Pro Asp Met Lys Lys Leu Lys Lys Ala Arg Ala 
        675                 680                 685             


Leu Thr Ile Thr Ala Ile Ala Gln Leu Phe Leu Leu Gly Cys Thr Trp 
    690                 695                 700                 


Val Phe Gly Leu Phe Ile Phe Asp Asp Arg Ser Leu Val Leu Thr Tyr 
705                 710                 715                 720 


Val Phe Thr Ile Leu Asn Cys Leu Gln Gly Ala Phe Leu Tyr Leu Leu 
                725                 730                 735     


His Cys Leu Leu Asn Lys Lys Val Arg Glu Glu Tyr Arg Lys Trp Ala 
            740                 745                 750         


Cys Leu Val Ala Gly Gly Ser Lys Tyr Ser Glu Phe Thr Ser Thr Thr 
        755                 760                 765             


Ser Gly Thr Gly His Asn Gln Thr Arg Ala Leu Arg Ala Ser Glu Ser 
    770                 775                 780                 


Gly Ile 
785     


<210>  699
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  699

Met Gly Ala Thr Thr Met Asp Gln Lys Ser Leu Trp Ala Gly Ser Ala 
1               5                   10                  15      


Tyr Lys Leu Val Cys Tyr Phe Thr Asn Trp Ser Gln Asp Arg Gln Glu 
            20                  25                  30          


Pro Gly Lys Phe Thr Pro Glu Asn Ile Asp Pro Phe Leu Cys Ser His 
        35                  40                  45              


Leu Ile Tyr Ser Phe Ala Ser Ile Glu Asn Asn Lys Val Ile Ile Lys 
    50                  55                  60                  


Asp Lys Ser Glu Val Met Leu Tyr Gln Thr Ile Asn Ser Leu Lys Thr 
65                  70                  75                  80  


Lys Asn Pro Lys Leu Lys Ile Leu Leu Ser Ile Gly Gly Tyr Leu Phe 
                85                  90                  95      


Gly Ser Lys Gly Phe His Pro Met Val Asp Ser Ser Thr Ser Arg Leu 
            100                 105                 110         


Glu Phe Ile Asn Ser Ile Ile Leu Phe Leu Arg Asn His Asn Phe Asp 
        115                 120                 125             


Gly Leu Asp Val Ser Trp Ile Tyr Pro Asp Gln Lys Glu Asn Thr His 
    130                 135                 140                 


Phe Thr Val Leu Ile His Glu Leu Ala Glu Ala Phe Gln Lys Asp Phe 
145                 150                 155                 160 


Thr Lys Ser Thr Lys Glu Arg Leu Leu Leu Thr Ala Gly Val Ser Ala 
                165                 170                 175     


Gly Arg Gln Met Ile Asp Asn Ser Tyr Gln Val Glu Lys Leu Ala Lys 
            180                 185                 190         


Asp Leu Asp Phe Ile Asn Leu Leu Ser Phe Asp Phe His Gly Ser Trp 
        195                 200                 205             


Glu Lys Pro Leu Ile Thr Gly His Asn Ser Pro Leu Ser Lys Gly Trp 
    210                 215                 220                 


Gln Asp Arg Gly Pro Ser Ser Tyr Tyr Asn Val Glu Tyr Ala Val Gly 
225                 230                 235                 240 


Tyr Trp Ile His Lys Gly Met Pro Ser Glu Lys Val Val Met Gly Ile 
                245                 250                 255     


Pro Thr Tyr Gly His Ser Phe Thr Leu Ala Ser Ala Glu Thr Thr Val 
            260                 265                 270         


Gly Ala Pro Ala Ser Gly Pro Gly Ala Ala Gly Pro Ile Thr Glu Ser 
        275                 280                 285             


Ser Gly Phe Leu Ala Tyr Tyr Glu Ile Cys Gln Phe Leu Lys Gly Ala 
    290                 295                 300                 


Lys Ile Thr Arg Leu Gln Asp Gln Gln Val Pro Tyr Ala Val Lys Gly 
305                 310                 315                 320 


Asn Gln Trp Val Gly Tyr Asp Asp Val Lys Ser Met Glu Thr Lys Val 
                325                 330                 335     


Gln Phe Leu Lys Asn Leu Asn Leu Gly Gly Ala Met Ile Trp Ser Ile 
            340                 345                 350         


Asp Met Asp Asp Phe Thr Gly Lys Ser Cys Asn Gln Gly Pro Tyr Pro 
        355                 360                 365             


Leu Val Gln Ala Val Lys Arg Ser Leu Gly Ser Leu 
    370                 375                 380 


<210>  700
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  700

Met Leu Tyr Gln Thr Ile Asn Ser Leu Lys Thr Lys Asn Pro Lys Leu 
1               5                   10                  15      


Lys Ile Leu Leu Ser Ile Gly Gly Tyr Leu Phe Gly Ser Lys Gly Phe 
            20                  25                  30          


His Pro Met Val Asp Ser Ser Thr Ser Arg Leu Glu Phe Ile Asn Ser 
        35                  40                  45              


Ile Ile Leu Phe Leu Arg Asn His Asn Phe Asp Gly Leu Asp Val Ser 
    50                  55                  60                  


Trp Ile Tyr Pro Asp Gln Lys Glu Asn Thr His Phe Thr Val Leu Ile 
65                  70                  75                  80  


His Glu Leu Ala Glu Ala Phe Gln Lys Asp Phe Thr Lys Ser Thr Lys 
                85                  90                  95      


Glu Arg Leu Leu Leu Thr Ala Gly Val Ser Ala Gly Arg Gln Met Ile 
            100                 105                 110         


Asp Asn Ser Tyr Gln Val Glu Lys Leu Ala Lys Asp Leu Asp Phe Ile 
        115                 120                 125             


Asn Leu Leu Ser Phe Asp Phe His Gly Ser Trp Glu Lys Pro Leu Ile 
    130                 135                 140                 


Thr Gly His Asn Ser Pro Leu Ser Lys Gly Trp Gln Asp Arg Gly Pro 
145                 150                 155                 160 


Ser Ser Tyr Tyr Asn Val Glu Tyr Ala Val Gly Tyr Trp Ile His Lys 
                165                 170                 175     


Gly Met Pro Ser Glu Lys Val Val Met Gly Ile Pro Thr Tyr Gly His 
            180                 185                 190         


Ser Phe Thr Leu Ala Ser Ala Glu Thr Thr Val Gly Ala Pro Ala Ser 
        195                 200                 205             


Gly Pro Gly Ala Ala Gly Pro Ile Thr Glu Ser Ser Gly Phe Leu Ala 
    210                 215                 220                 


Tyr Tyr Glu Ile Cys Gln Phe Leu Lys Gly Ala Lys Ile Thr Arg Leu 
225                 230                 235                 240 


Gln Asp Gln Gln Val Pro Tyr Ala Val Lys Gly Asn Gln Trp Val Gly 
                245                 250                 255     


Tyr Asp Asp Val Lys Ser Met Glu Thr Lys Val Gln Phe Leu Lys Asn 
            260                 265                 270         


Leu Asn Leu Gly Gly Ala Met Ile Trp Ser Ile Asp Met Asp Asp Phe 
        275                 280                 285             


Thr Gly Lys Ser Cys Asn Gln Gly Pro Tyr Pro Leu Val Gln Ala Val 
    290                 295                 300                 


Lys Arg Ser Leu Gly Ser Leu 
305                 310     


<210>  701
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  701

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly Cys Gly Val Pro Ala Ile His Pro Val Leu Ser Gly Leu Ser 
            20                  25                  30          


Arg Ile Val Asn Gly Glu Asp Ala Val Pro Gly Ser Trp Pro Trp Gln 
        35                  40                  45              


Val Ser Leu Gln Asp Lys Thr Gly Phe His Phe Cys Gly Gly Ser Leu 
    50                  55                  60                  


Ile Ser Glu Asp Trp Val Val Thr Ala Ala His Cys Gly Val Arg Thr 
65                  70                  75                  80  


Ser Asp Val Val Val Ala Gly Glu Phe Asp Gln Gly Ser Asp Glu Glu 
                85                  90                  95      


Asn Ile Gln Val Leu Lys Ile Ala Lys Val Phe Lys Asn Pro Lys Phe 
            100                 105                 110         


Ser Ile Leu Thr Val Asn Asn Asp Ile Thr Leu Leu Lys Leu Ala Thr 
        115                 120                 125             


Pro Ala Arg Phe Ser Gln Thr Val Ser Ala Val Cys Leu Pro Ser Ala 
    130                 135                 140                 


Asp Asp Asp Phe Pro Ala Gly Thr Leu Cys Ala Thr Thr Gly Trp Gly 
145                 150                 155                 160 


Lys Thr Lys Tyr Asn Ala Asn Lys Thr Pro Asp Lys Leu Gln Gln Ala 
                165                 170                 175     


Ala Leu Pro Leu Leu Ser Asn Ala Glu Cys Lys Lys Ser Trp Gly Arg 
            180                 185                 190         


Arg Ile Thr Asp Val Met Ile Cys Ala Gly Ala Ser Gly Val Ser Ser 
        195                 200                 205             


Cys Met Gly Asp Ser Gly Gly Pro Leu Val Cys Gln Lys Asp Gly Ala 
    210                 215                 220                 


Trp Thr Leu Val Gly Ile Val Ser Trp Gly Ser Arg Thr Cys Ser Thr 
225                 230                 235                 240 


Thr Thr Pro Ala Val Tyr Ala Arg Val Ala Lys Leu Ile Pro Trp Val 
                245                 250                 255     


Gln Lys Ile Leu Ala Ala Asn 
            260             


<210>  702
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  702

Met Ala Arg Ala Cys Leu Gln Ala Val Lys Tyr Leu Met Phe Ala Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Leu Gly Gly Cys Gly Val Leu Gly Val Gly Ile 
            20                  25                  30          


Trp Leu Ala Ala Thr Gln Gly Ser Phe Ala Thr Leu Ser Ser Ser Phe 
        35                  40                  45              


Pro Ser Leu Ser Ala Ala Asn Leu Leu Ile Ile Thr Gly Ala Phe Val 
    50                  55                  60                  


Met Ala Ile Gly Phe Val Gly Cys Leu Gly Ala Ile Lys Glu Asn Lys 
65                  70                  75                  80  


Cys Leu Leu Leu Thr Phe Phe Leu Leu Leu Leu Leu Val Phe Leu Leu 
                85                  90                  95      


Glu Ala Thr Ile Ala Ile Leu Phe Phe Ala Tyr Thr Asp Lys Ile Asp 
            100                 105                 110         


Arg Tyr Ala Gln Gln Asp Leu Lys Lys Gly Leu His Leu Tyr Gly Thr 
        115                 120                 125             


Gln Gly Asn Val Gly Leu Thr Asn Ala Trp Ser Ile Ile Gln Thr Asp 
    130                 135                 140                 


Phe Arg Cys Cys Gly Val Ser Asn Tyr Thr Asp Trp Phe Glu Val Tyr 
145                 150                 155                 160 


Asn Ala Thr Arg Val Pro Asp Ser Cys Cys Leu Glu Phe Ser Glu Ser 
                165                 170                 175     


Cys Gly Leu His Ala Pro Gly Thr Trp Trp Lys Ala Pro Cys Tyr Glu 
            180                 185                 190         


Thr Val Lys Val Trp Leu Gln Glu Asn Leu Leu Ala Val Gly Ile Phe 
        195                 200                 205             


Gly Leu Cys Thr Ala Leu Val Gln Ile Leu Gly Leu Thr Phe Ala Met 
    210                 215                 220                 


Thr Met Tyr Cys Gln Val Val Lys Ala Asp Thr Tyr Cys Ala 
225                 230                 235             


<210>  703
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  703

Met Ala Arg Ala Cys Leu Gln Ala Val Lys Tyr Leu Met Phe Ala Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Leu Gly Gly Cys Gly Val Leu Gly Val Gly Ile 
            20                  25                  30          


Trp Leu Ala Ala Thr Gln Gly Ser Phe Ala Thr Leu Ser Ser Ser Phe 
        35                  40                  45              


Pro Ser Leu Ser Ala Ala Asn Leu Leu Ile Ile Thr Gly Ala Phe Val 
    50                  55                  60                  


Met Ala Ile Gly Phe Val Gly Cys Leu Gly Ala Ile Lys Glu Asn Lys 
65                  70                  75                  80  


Cys Leu Leu Leu Thr Phe Phe Leu Leu Leu Leu Leu Val Phe Leu Leu 
                85                  90                  95      


Glu Ala Thr Ile Ala Ile Leu Phe Phe Ala Tyr Thr Asp Lys Ile Asp 
            100                 105                 110         


Arg Tyr Ala Gln Gln Asp Leu Lys Lys Gly Leu His Leu Tyr Gly Thr 
        115                 120                 125             


Gln Gly Asn Val Gly Leu Thr Asn Ala Trp Ser Ile Ile Gln Thr Asp 
    130                 135                 140                 


Phe Arg Cys Cys Gly Val Ser Asn Tyr Thr Asp Trp Phe Glu Val Tyr 
145                 150                 155                 160 


Asn Ala Thr Arg Val Pro Asp Ser Cys Cys Leu Glu Phe Ser Glu Ser 
                165                 170                 175     


Cys Gly Leu His Ala Pro Gly Thr Trp Trp Lys Ala Pro Cys Tyr Glu 
            180                 185                 190         


Thr Val Lys Val Trp Leu Gln Glu Asn Leu Leu Ala Val Gly Ile Phe 
        195                 200                 205             


Gly Leu Cys Thr Ala Leu Val Gln Ile Leu Gly Leu Thr Phe Ala Met 
    210                 215                 220                 


Thr Met Tyr Cys Gln Val Val Lys Ala Asp Thr Tyr Cys Ala 
225                 230                 235             


<210>  704
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  704

Met Ala Arg Ala Cys Leu Gln Ala Val Lys Tyr Leu Met Phe Ala Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Leu Gly Gly Cys Gly Val Leu Gly Val Gly Ile 
            20                  25                  30          


Trp Leu Ala Ala Thr Gln Gly Ser Phe Ala Thr Leu Ser Ser Ser Phe 
        35                  40                  45              


Pro Ser Leu Ser Ala Ala Asn Leu Leu Ile Ile Thr Gly Ala Phe Val 
    50                  55                  60                  


Met Ala Ile Gly Phe Val Gly Cys Leu Gly Ala Ile Lys Glu Asn Lys 
65                  70                  75                  80  


Cys Leu Leu Leu Thr Phe Phe Leu Leu Leu Leu Leu Val Phe Leu Leu 
                85                  90                  95      


Glu Ala Thr Ile Ala Ile Leu Phe Phe Ala Tyr Thr Asp Lys Ile Asp 
            100                 105                 110         


Arg Tyr Ala Gln Gln Asp Leu Lys Lys Gly Leu His Leu Tyr Gly Thr 
        115                 120                 125             


Gln Gly Asn Val Gly Leu Thr Asn Ala Trp Ser Ile Ile Gln Thr Asp 
    130                 135                 140                 


Phe Arg Cys Cys Gly Val Ser Asn Tyr Thr Asp Trp Phe Glu Val Tyr 
145                 150                 155                 160 


Asn Ala Thr Arg Val Pro Asp Ser Cys Cys Leu Glu Phe Ser Glu Ser 
                165                 170                 175     


Cys Gly Leu His Ala Pro Gly Thr Trp Trp Lys Ala Pro Cys Tyr Glu 
            180                 185                 190         


Thr Val Lys Val Trp Leu Gln Glu Asn Leu Leu Ala Val Gly Ile Phe 
        195                 200                 205             


Gly Leu Cys Thr Ala Leu Val Gln Ile Leu Gly Leu Thr Phe Ala Met 
    210                 215                 220                 


Thr Met Tyr Cys Gln Val Val Lys Ala Asp Thr Tyr Cys Ala 
225                 230                 235             


<210>  705
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  705

Met Ala Arg Ala Cys Leu Gln Ala Val Lys Tyr Leu Met Phe Ala Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Leu Gly Gly Cys Gly Val Leu Gly Val Gly Ile 
            20                  25                  30          


Trp Leu Ala Ala Thr Gln Gly Ser Phe Ala Thr Leu Ser Ser Ser Phe 
        35                  40                  45              


Pro Ser Leu Ser Ala Ala Asn Leu Leu Ile Ile Thr Gly Ala Phe Val 
    50                  55                  60                  


Met Ala Ile Gly Phe Val Gly Cys Leu Gly Ala Ile Lys Glu Asn Lys 
65                  70                  75                  80  


Cys Leu Leu Leu Thr Phe Phe Leu Leu Leu Leu Leu Val Phe Leu Leu 
                85                  90                  95      


Glu Ala Thr Ile Ala Ile Leu Phe Phe Ala Tyr Thr Asp Lys Ile Asp 
            100                 105                 110         


Arg Tyr Ala Gln Gln Asp Leu Lys Lys Gly Leu His Leu Tyr Gly Thr 
        115                 120                 125             


Gln Gly Asn Val Gly Leu Thr Asn Ala Trp Ser Ile Ile Gln Thr Asp 
    130                 135                 140                 


Phe Arg Cys Cys Gly Val Ser Asn Tyr Thr Asp Trp Phe Glu Val Tyr 
145                 150                 155                 160 


Asn Ala Thr Arg Val Pro Asp Ser Cys Cys Leu Glu Phe Ser Glu Ser 
                165                 170                 175     


Cys Gly Leu His Ala Pro Gly Thr Trp Trp Lys Ala Pro Cys Tyr Glu 
            180                 185                 190         


Thr Val Lys Val Trp Leu Gln Glu Asn Leu Leu Ala Val Gly Ile Phe 
        195                 200                 205             


Gly Leu Cys Thr Ala Leu Val Gln Ile Leu Gly Leu Thr Phe Ala Met 
    210                 215                 220                 


Thr Met Tyr Cys Gln Val Val Lys Ala Asp Thr Tyr Cys Ala 
225                 230                 235             


<210>  706
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  706

Met Ala Arg Ala Cys Leu Gln Ala Val Lys Tyr Leu Met Phe Ala Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Leu Gly Gly Cys Gly Val Leu Gly Val Gly Ile 
            20                  25                  30          


Trp Leu Ala Ala Thr Gln Gly Ser Phe Ala Thr Leu Ser Ser Ser Phe 
        35                  40                  45              


Pro Ser Leu Ser Ala Ala Asn Leu Leu Ile Ile Thr Gly Ala Phe Val 
    50                  55                  60                  


Met Ala Ile Gly Phe Val Gly Cys Leu Gly Ala Ile Lys Glu Asn Lys 
65                  70                  75                  80  


Cys Leu Leu Leu Thr Phe Phe Leu Leu Leu Leu Leu Val Phe Leu Leu 
                85                  90                  95      


Glu Ala Thr Ile Ala Ile Leu Phe Phe Ala Tyr Thr Asp Lys Ile Asp 
            100                 105                 110         


Arg Tyr Ala Gln Gln Asp Leu Lys Lys Gly Leu His Leu Tyr Gly Thr 
        115                 120                 125             


Gln Gly Asn Val Gly Leu Thr Asn Ala Trp Ser Ile Ile Gln Thr Asp 
    130                 135                 140                 


Phe Arg Cys Cys Gly Val Ser Asn Tyr Thr Asp Trp Phe Glu Val Tyr 
145                 150                 155                 160 


Asn Ala Thr Arg Val Pro Asp Ser Cys Cys Leu Glu Phe Ser Glu Ser 
                165                 170                 175     


Cys Gly Leu His Ala Pro Gly Thr Trp Trp Lys Ala Pro Cys Tyr Glu 
            180                 185                 190         


Thr Val Lys Val Trp Leu Gln Glu Asn Leu Leu Ala Val Gly Ile Phe 
        195                 200                 205             


Gly Leu Cys Thr Ala Leu Val Gln Ile Leu Gly Leu Thr Phe Ala Met 
    210                 215                 220                 


Thr Met Tyr Cys Gln Val Val Lys Ala Asp Thr Tyr Cys Ala 
225                 230                 235             


<210>  707
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  707

Met Ala Ile Gly Phe Val Gly Cys Leu Gly Ala Ile Lys Glu Asn Lys 
1               5                   10                  15      


Cys Leu Leu Leu Thr Phe Phe Leu Leu Leu Leu Leu Val Phe Leu Leu 
            20                  25                  30          


Glu Ala Thr Ile Ala Ile Leu Phe Phe Ala Tyr Thr Asp Lys Ile Asp 
        35                  40                  45              


Arg Tyr Ala Gln Gln Asp Leu Lys Lys Gly Leu His Leu Tyr Gly Thr 
    50                  55                  60                  


Gln Gly Asn Val Gly Leu Thr Asn Ala Trp Ser Ile Ile Gln Thr Asp 
65                  70                  75                  80  


Phe Arg Cys Cys Gly Val Ser Asn Tyr Thr Asp Trp Phe Glu Val Tyr 
                85                  90                  95      


Asn Ala Thr Arg Val Pro Asp Ser Cys Cys Leu Glu Phe Ser Glu Ser 
            100                 105                 110         


Cys Gly Leu His Ala Pro Gly Thr Trp Trp Lys Ala Pro Cys Tyr Glu 
        115                 120                 125             


Thr Val Lys Val Trp Leu Gln Glu Asn Leu Leu Ala Val Gly Ile Phe 
    130                 135                 140                 


Gly Leu Cys Thr Ala Leu Val Gln Ile Leu Gly Leu Thr Phe Ala Met 
145                 150                 155                 160 


Thr Met Tyr Cys Gln Val Val Lys Ala Asp Thr Tyr Cys Ala 
                165                 170                 


<210>  708
<211>  910
<212>  PRT
<213>  Homo sapiens

<400>  708

Met Lys Lys Met Ser Arg Asn Val Leu Leu Gln Met Glu Glu Glu Glu 
1               5                   10                  15      


Asp Asp Asp Asp Gly Asp Ile Val Leu Glu Asn Leu Gly Gln Thr Ile 
            20                  25                  30          


Val Pro Asp Leu Gly Ser Leu Glu Ser Gln His Asp Phe Arg Thr Pro 
        35                  40                  45              


Glu Phe Glu Glu Phe Asn Gly Lys Pro Asp Ser Leu Phe Phe Asn Asp 
    50                  55                  60                  


Gly Gln Arg Arg Ile Asp Phe Val Leu Val Tyr Glu Asp Glu Ser Arg 
65                  70                  75                  80  


Lys Glu Thr Asn Lys Lys Gly Thr Asn Glu Lys Gln Arg Arg Lys Arg 
                85                  90                  95      


Gln Ala Tyr Glu Ser Asn Leu Ile Cys His Gly Leu Gln Leu Glu Ala 
            100                 105                 110         


Thr Arg Ser Val Leu Asp Asp Lys Leu Val Phe Val Lys Val His Ala 
        115                 120                 125             


Pro Trp Glu Val Leu Cys Thr Tyr Ala Glu Ile Met His Ile Lys Leu 
    130                 135                 140                 


Pro Leu Lys Pro Asn Asp Leu Lys Asn Arg Ser Ser Ala Phe Gly Thr 
145                 150                 155                 160 


Leu Asn Trp Phe Thr Lys Val Leu Ser Val Asp Glu Ser Ile Ile Lys 
                165                 170                 175     


Pro Glu Gln Glu Phe Phe Thr Ala Pro Phe Glu Lys Asn Arg Met Asn 
            180                 185                 190         


Asp Phe Tyr Ile Val Asp Arg Asp Ala Phe Phe Asn Pro Ala Thr Arg 
        195                 200                 205             


Ser Arg Ile Val Tyr Phe Ile Leu Ser Arg Val Lys Tyr Gln Val Ile 
    210                 215                 220                 


Asn Asn Val Ser Lys Phe Gly Ile Asn Arg Leu Val Asn Ser Gly Ile 
225                 230                 235                 240 


Tyr Lys Ala Ala Phe Pro Leu His Asp Cys Lys Phe Arg Arg Gln Ser 
                245                 250                 255     


Glu Asp Pro Ser Cys Pro Asn Glu Arg Tyr Leu Leu Tyr Arg Glu Trp 
            260                 265                 270         


Ala His Pro Arg Ser Ile Tyr Lys Lys Gln Pro Leu Asp Leu Ile Arg 
        275                 280                 285             


Lys Tyr Tyr Gly Glu Lys Ile Gly Ile Tyr Phe Ala Trp Leu Gly Tyr 
    290                 295                 300                 


Tyr Thr Gln Met Leu Leu Leu Ala Ala Val Val Gly Val Ala Cys Phe 
305                 310                 315                 320 


Leu Tyr Gly Tyr Leu Asn Gln Asp Asn Cys Thr Trp Ser Lys Glu Val 
                325                 330                 335     


Cys His Pro Asp Ile Gly Gly Lys Ile Ile Met Cys Pro Gln Cys Asp 
            340                 345                 350         


Arg Leu Cys Pro Phe Trp Lys Leu Asn Ile Thr Cys Glu Ser Ser Lys 
        355                 360                 365             


Lys Leu Cys Ile Phe Asp Ser Phe Gly Thr Leu Val Phe Ala Val Phe 
    370                 375                 380                 


Met Gly Val Trp Val Thr Leu Phe Leu Glu Phe Trp Lys Arg Arg Gln 
385                 390                 395                 400 


Ala Glu Leu Glu Tyr Glu Trp Asp Thr Val Glu Leu Gln Gln Glu Glu 
                405                 410                 415     


Gln Ala Arg Pro Glu Tyr Glu Ala Arg Cys Thr His Val Val Ile Asn 
            420                 425                 430         


Glu Ile Thr Gln Glu Glu Glu Arg Ile Pro Phe Thr Ala Trp Gly Lys 
        435                 440                 445             


Cys Ile Arg Ile Thr Leu Cys Ala Ser Ala Val Phe Phe Trp Ile Leu 
    450                 455                 460                 


Leu Ile Ile Ala Ser Val Ile Gly Ile Ile Val Tyr Arg Leu Ser Val 
465                 470                 475                 480 


Phe Ile Val Phe Ser Ala Lys Leu Pro Lys Asn Ile Asn Gly Thr Asp 
                485                 490                 495     


Pro Ile Gln Lys Tyr Leu Thr Pro Gln Thr Ala Thr Ser Ile Thr Ala 
            500                 505                 510         


Ser Ile Ile Ser Phe Ile Ile Ile Met Ile Leu Asn Thr Ile Tyr Glu 
        515                 520                 525             


Lys Val Ala Ile Met Ile Thr Asn Phe Glu Leu Pro Arg Thr Gln Thr 
    530                 535                 540                 


Asp Tyr Glu Asn Ser Leu Thr Met Lys Met Phe Leu Phe Gln Phe Val 
545                 550                 555                 560 


Asn Tyr Tyr Ser Ser Cys Phe Tyr Ile Ala Phe Phe Lys Gly Lys Phe 
                565                 570                 575     


Val Gly Tyr Pro Gly Asp Pro Val Tyr Trp Leu Gly Lys Tyr Arg Asn 
            580                 585                 590         


Glu Glu Cys Asp Pro Gly Gly Cys Leu Leu Glu Leu Thr Thr Gln Leu 
        595                 600                 605             


Thr Ile Ile Met Gly Gly Lys Ala Ile Trp Asn Asn Ile Gln Glu Val 
    610                 615                 620                 


Leu Leu Pro Trp Ile Met Asn Leu Ile Gly Arg Phe His Arg Val Ser 
625                 630                 635                 640 


Gly Ser Glu Lys Ile Thr Pro Arg Trp Glu Gln Asp Tyr His Leu Gln 
                645                 650                 655     


Pro Met Gly Lys Leu Gly Leu Phe Tyr Glu Tyr Leu Glu Met Ile Ile 
            660                 665                 670         


Gln Phe Gly Phe Val Thr Leu Phe Val Ala Ser Phe Pro Leu Ala Pro 
        675                 680                 685             


Leu Leu Ala Leu Val Asn Asn Ile Leu Glu Ile Arg Val Asp Ala Trp 
    690                 695                 700                 


Lys Leu Thr Thr Gln Phe Arg Arg Leu Val Pro Glu Lys Ala Gln Asp 
705                 710                 715                 720 


Ile Gly Ala Trp Gln Pro Ile Met Gln Gly Ile Ala Ile Leu Ala Val 
                725                 730                 735     


Val Thr Asn Ala Met Ile Ile Ala Phe Thr Ser Asp Met Ile Pro Arg 
            740                 745                 750         


Leu Val Tyr Tyr Trp Ser Phe Ser Val Pro Pro Tyr Gly Asp His Thr 
        755                 760                 765             


Ser Tyr Thr Met Glu Gly Tyr Ile Asn Asn Thr Leu Ser Ile Phe Lys 
    770                 775                 780                 


Val Ala Asp Phe Lys Asn Lys Ser Lys Gly Asn Pro Tyr Ser Asp Leu 
785                 790                 795                 800 


Gly Asn His Thr Thr Cys Arg Tyr Arg Asp Phe Arg Tyr Pro Pro Gly 
                805                 810                 815     


His Pro Gln Glu Tyr Lys His Asn Ile Tyr Tyr Trp His Val Ile Ala 
            820                 825                 830         


Ala Lys Leu Ala Phe Ile Ile Val Met Glu His Val Ile Tyr Ser Val 
        835                 840                 845             


Lys Phe Phe Ile Ser Tyr Ala Ile Pro Asp Val Ser Lys Arg Thr Lys 
    850                 855                 860                 


Ser Lys Ile Gln Arg Glu Lys Tyr Leu Thr Gln Lys Leu Leu His Glu 
865                 870                 875                 880 


Asn His Leu Lys Asp Met Thr Lys Asn Met Gly Val Ile Ala Glu Arg 
                885                 890                 895     


Met Ile Glu Ala Val Asp Asn Asn Leu Arg Pro Lys Ser Glu 
            900                 905                 910 


<210>  709
<211>  1555
<212>  PRT
<213>  Homo sapiens

<400>  709

Met Gly Cys Lys Gly Asp Ala Ser Gly Ala Cys Ala Ala Gly Ala Leu 
1               5                   10                  15      


Pro Val Thr Gly Val Cys Tyr Lys Met Gly Val Leu Val Val Leu Thr 
            20                  25                  30          


Val Leu Trp Leu Phe Ser Ser Val Lys Ala Asp Ser Lys Ala Ile Thr 
        35                  40                  45              


Thr Ser Leu Thr Thr Lys Trp Phe Ser Thr Pro Leu Leu Leu Glu Ala 
    50                  55                  60                  


Ser Glu Phe Leu Ala Glu Asp Ser Gln Glu Lys Phe Trp Asn Phe Val 
65                  70                  75                  80  


Glu Ala Ser Gln Asn Ile Gly Ser Ser Asp His Asp Gly Thr Asp Tyr 
                85                  90                  95      


Ser Tyr Tyr His Ala Ile Leu Glu Ala Ala Phe Gln Phe Leu Ser Pro 
            100                 105                 110         


Leu Gln Gln Asn Leu Phe Lys Phe Cys Leu Ser Leu Arg Ser Tyr Ser 
        115                 120                 125             


Ala Thr Ile Gln Ala Phe Gln Gln Ile Ala Ala Asp Glu Pro Pro Pro 
    130                 135                 140                 


Glu Gly Cys Asn Ser Phe Phe Ser Val His Gly Lys Lys Thr Cys Glu 
145                 150                 155                 160 


Ser Asp Thr Leu Glu Ala Leu Leu Leu Thr Ala Ser Glu Arg Pro Lys 
                165                 170                 175     


Pro Leu Leu Phe Lys Gly Asp His Arg Tyr Pro Ser Ser Asn Pro Glu 
            180                 185                 190         


Ser Pro Val Val Ile Phe Tyr Ser Glu Ile Gly Ser Glu Glu Phe Ser 
        195                 200                 205             


Asn Phe His Arg Gln Leu Ile Ser Lys Ser Asn Ala Gly Lys Ile Asn 
    210                 215                 220                 


Tyr Val Phe Arg His Tyr Ile Phe Asn Pro Arg Lys Glu Pro Val Tyr 
225                 230                 235                 240 


Leu Ser Gly Tyr Gly Val Glu Leu Ala Ile Lys Ser Thr Glu Tyr Lys 
                245                 250                 255     


Ala Lys Asp Asp Thr Gln Val Lys Gly Thr Glu Val Asn Thr Thr Val 
            260                 265                 270         


Ile Gly Glu Asn Asp Pro Ile Asp Glu Val Gln Gly Phe Leu Phe Gly 
        275                 280                 285             


Lys Leu Arg Asp Leu His Pro Asp Leu Glu Gly Gln Leu Lys Glu Leu 
    290                 295                 300                 


Arg Lys His Leu Val Glu Ser Thr Asn Glu Met Ala Pro Leu Lys Val 
305                 310                 315                 320 


Trp Gln Leu Gln Asp Leu Ser Phe Gln Thr Ala Ala Arg Ile Leu Ala 
                325                 330                 335     


Ser Pro Val Glu Leu Ala Leu Val Val Met Lys Asp Leu Ser Gln Asn 
            340                 345                 350         


Phe Pro Thr Lys Ala Arg Ala Ile Thr Lys Thr Ala Val Ser Ser Glu 
        355                 360                 365             


Leu Arg Thr Glu Val Glu Glu Asn Gln Lys Tyr Phe Lys Gly Thr Leu 
    370                 375                 380                 


Gly Leu Gln Pro Gly Asp Ser Ala Leu Phe Ile Asn Gly Leu His Met 
385                 390                 395                 400 


Asp Leu Asp Thr Gln Asp Ile Phe Ser Leu Phe Asp Val Leu Arg Asn 
                405                 410                 415     


Glu Ala Arg Val Met Glu Gly Leu His Arg Leu Gly Ile Glu Gly Leu 
            420                 425                 430         


Ser Leu His Asn Val Leu Lys Leu Asn Ile Gln Pro Ser Glu Ala Asp 
        435                 440                 445             


Tyr Ala Val Asp Ile Arg Ser Pro Ala Ile Ser Trp Val Asn Asn Leu 
    450                 455                 460                 


Glu Val Asp Ser Arg Tyr Asn Ser Trp Pro Ser Ser Leu Gln Glu Leu 
465                 470                 475                 480 


Leu Arg Pro Thr Phe Pro Gly Val Ile Arg Gln Ile Arg Lys Asn Leu 
                485                 490                 495     


His Asn Met Val Phe Ile Val Asp Pro Ala His Glu Thr Thr Ala Glu 
            500                 505                 510         


Leu Met Asn Thr Ala Glu Met Phe Leu Ser Asn His Ile Pro Leu Arg 
        515                 520                 525             


Ile Gly Phe Ile Phe Val Val Asn Asp Ser Glu Asp Val Asp Gly Met 
    530                 535                 540                 


Gln Asp Ala Gly Val Ala Val Leu Arg Ala Tyr Asn Tyr Val Ala Gln 
545                 550                 555                 560 


Glu Val Asp Asp Tyr His Ala Phe Gln Thr Leu Thr His Ile Tyr Asn 
                565                 570                 575     


Lys Val Arg Thr Gly Glu Lys Val Lys Val Glu His Val Val Ser Val 
            580                 585                 590         


Leu Glu Lys Lys Tyr Pro Tyr Val Glu Val Asn Ser Ile Leu Gly Ile 
        595                 600                 605             


Asp Ser Ala Tyr Asp Arg Asn Arg Lys Glu Ala Arg Gly Tyr Tyr Glu 
    610                 615                 620                 


Gln Thr Gly Val Gly Pro Leu Pro Val Val Leu Phe Asn Gly Met Pro 
625                 630                 635                 640 


Phe Glu Arg Glu Gln Leu Asp Pro Asp Glu Leu Glu Thr Ile Thr Met 
                645                 650                 655     


His Lys Ile Leu Glu Thr Thr Thr Phe Phe Gln Arg Ala Val Tyr Leu 
            660                 665                 670         


Gly Glu Leu Pro His Asp Gln Asp Val Val Glu Tyr Ile Met Asn Gln 
        675                 680                 685             


Pro Asn Val Val Pro Arg Ile Asn Ser Arg Ile Leu Thr Ala Glu Arg 
    690                 695                 700                 


Asp Tyr Leu Asp Leu Thr Ala Ser Asn Asn Phe Phe Val Asp Asp Tyr 
705                 710                 715                 720 


Ala Arg Phe Thr Ile Leu Asp Ser Gln Gly Lys Thr Ala Ala Val Ala 
                725                 730                 735     


Asn Ser Met Asn Tyr Leu Thr Lys Lys Gly Met Ser Ser Lys Glu Ile 
            740                 745                 750         


Tyr Asp Asp Ser Phe Ile Arg Pro Val Thr Phe Trp Ile Val Gly Asp 
        755                 760                 765             


Phe Asp Ser Pro Ser Gly Arg Gln Leu Leu Tyr Asp Ala Ile Lys His 
    770                 775                 780                 


Gln Lys Ser Ser Asn Asn Val Arg Ile Ser Met Ile Asn Asn Pro Ala 
785                 790                 795                 800 


Lys Glu Ile Ser Tyr Glu Asn Thr Gln Ile Ser Arg Ala Ile Trp Ala 
                805                 810                 815     


Ala Leu Gln Thr Gln Thr Ser Asn Ala Ala Lys Asn Phe Ile Thr Lys 
            820                 825                 830         


Met Ala Lys Glu Gly Ala Ala Glu Ala Leu Ala Ala Gly Ala Asp Ile 
        835                 840                 845             


Ala Glu Phe Ser Val Gly Gly Met Asp Phe Ser Leu Phe Lys Glu Val 
    850                 855                 860                 


Phe Glu Ser Ser Lys Met Asp Phe Ile Leu Ser His Ala Val Tyr Cys 
865                 870                 875                 880 


Arg Asp Val Leu Lys Leu Lys Lys Gly Gln Arg Ala Val Ile Ser Asn 
                885                 890                 895     


Gly Arg Ile Ile Gly Pro Leu Glu Asp Ser Glu Leu Phe Asn Gln Asp 
            900                 905                 910         


Asp Phe His Leu Leu Glu Asn Ile Ile Leu Lys Thr Ser Gly Gln Lys 
        915                 920                 925             


Ile Lys Ser His Ile Gln Gln Leu Arg Val Glu Glu Asp Val Ala Ser 
    930                 935                 940                 


Asp Leu Val Met Lys Val Asp Ala Leu Leu Ser Ala Gln Pro Lys Gly 
945                 950                 955                 960 


Asp Pro Arg Ile Glu Tyr Gln Phe Phe Glu Asp Arg His Ser Ala Ile 
                965                 970                 975     


Lys Leu Arg Pro Lys Glu Gly Glu Thr Tyr Phe Asp Val Val Ala Val 
            980                 985                 990         


Val Asp Pro Val Thr Arg Glu Ala  Gln Arg Leu Ala Pro  Leu Leu Leu 
        995                 1000                 1005             


Val Leu  Ala Gln Leu Ile Asn  Met Asn Leu Arg Val  Phe Met Asn 
    1010                 1015                 1020             


Cys Gln  Ser Lys Leu Ser Asp  Met Pro Leu Lys Ser  Phe Tyr Arg 
    1025                 1030                 1035             


Tyr Val  Leu Glu Pro Glu Ile  Ser Phe Thr Ser Asp  Asn Ser Phe 
    1040                 1045                 1050             


Ala Lys  Gly Pro Ile Ala Lys  Phe Leu Asp Met Pro  Gln Ser Pro 
    1055                 1060                 1065             


Leu Phe  Thr Leu Asn Leu Asn  Thr Pro Glu Ser Trp  Met Val Glu 
    1070                 1075                 1080             


Ser Val  Arg Thr Pro Tyr Asp  Leu Asp Asn Ile Tyr  Leu Glu Glu 
    1085                 1090                 1095             


Val Asp  Ser Val Val Ala Ala  Glu Tyr Glu Leu Glu  Tyr Leu Leu 
    1100                 1105                 1110             


Leu Glu  Gly His Cys Tyr Asp  Ile Thr Thr Gly Gln  Pro Pro Arg 
    1115                 1120                 1125             


Gly Leu  Gln Phe Thr Leu Gly  Thr Ser Ala Asn Pro  Val Ile Val 
    1130                 1135                 1140             


Asp Thr  Ile Val Met Ala Asn  Leu Gly Tyr Phe Gln  Leu Lys Ala 
    1145                 1150                 1155             


Asn Pro  Gly Ala Trp Ile Leu  Arg Leu Arg Lys Gly  Arg Ser Glu 
    1160                 1165                 1170             


Asp Ile  Tyr Arg Ile Tyr Ser  His Asp Gly Thr Asp  Ser Pro Pro 
    1175                 1180                 1185             


Asp Ala  Asp Glu Val Val Ile  Val Leu Asn Asn Phe  Lys Ser Lys 
    1190                 1195                 1200             


Ile Ile  Lys Val Lys Val Gln  Lys Lys Ala Asp Met  Val Asn Glu 
    1205                 1210                 1215             


Asp Leu  Leu Ser Asp Gly Thr  Ser Glu Asn Glu Ser  Gly Phe Trp 
    1220                 1225                 1230             


Asp Ser  Phe Lys Trp Gly Phe  Thr Gly Gln Lys Thr  Glu Glu Val 
    1235                 1240                 1245             


Lys Gln  Asp Lys Asp Asp Ile  Ile Asn Ile Phe Ser  Val Ala Ser 
    1250                 1255                 1260             


Gly His  Leu Tyr Glu Arg Phe  Leu Arg Ile Met Met  Leu Ser Val 
    1265                 1270                 1275             


Leu Lys  Asn Thr Lys Thr Pro  Val Lys Phe Trp Phe  Leu Lys Asn 
    1280                 1285                 1290             


Tyr Leu  Ser Pro Thr Phe Lys  Glu Phe Ile Pro Tyr  Met Ala Asn 
    1295                 1300                 1305             


Glu Tyr  Asn Phe Gln Tyr Glu  Leu Val Gln Tyr Lys  Trp Pro Arg 
    1310                 1315                 1320             


Trp Leu  His Gln Gln Thr Glu  Lys Gln Arg Ile Ile  Trp Gly Tyr 
    1325                 1330                 1335             


Lys Ile  Leu Phe Leu Asp Val  Leu Phe Pro Leu Val  Val Asp Lys 
    1340                 1345                 1350             


Phe Leu  Phe Val Asp Ala Asp  Gln Ile Val Arg Thr  Asp Leu Lys 
    1355                 1360                 1365             


Glu Leu  Arg Asp Phe Asn Leu  Asp Gly Ala Pro Tyr  Gly Tyr Thr 
    1370                 1375                 1380             


Pro Phe  Cys Asp Ser Arg Arg  Glu Met Asp Gly Tyr  Arg Phe Trp 
    1385                 1390                 1395             


Lys Ser  Gly Tyr Trp Ala Ser  His Leu Ala Gly Arg  Lys Tyr His 
    1400                 1405                 1410             


Ile Ser  Ala Leu Tyr Val Val  Asp Leu Lys Lys Phe  Arg Lys Ile 
    1415                 1420                 1425             


Ala Ala  Gly Asp Arg Leu Arg  Gly Gln Tyr Gln Gly  Leu Ser Gln 
    1430                 1435                 1440             


Asp Pro  Asn Ser Leu Ser Asn  Leu Asp Gln Asp Leu  Pro Asn Asn 
    1445                 1450                 1455             


Met Ile  His Gln Val Pro Ile  Lys Ser Leu Pro Gln  Glu Trp Leu 
    1460                 1465                 1470             


Trp Cys  Glu Thr Trp Cys Asp  Asp Ala Ser Lys Lys  Arg Ala Lys 
    1475                 1480                 1485             


Thr Ile  Asp Leu Cys Asn Asn  Pro Met Thr Lys Glu  Pro Lys Leu 
    1490                 1495                 1500             


Glu Ala  Ala Val Arg Ile Val  Pro Glu Trp Gln Asp  Tyr Asp Gln 
    1505                 1510                 1515             


Glu Ile  Lys Gln Leu Gln Ile  Arg Phe Gln Lys Glu  Lys Glu Thr 
    1520                 1525                 1530             


Gly Ala  Leu Tyr Lys Glu Lys  Thr Lys Glu Pro Ser  Arg Glu Gly 
    1535                 1540                 1545             


Pro Gln  Lys Arg Glu Glu Leu  
    1550                 1555 


<210>  710
<211>  408
<212>  PRT
<213>  Homo sapiens

<400>  710

Met Ile Pro Pro Glu Gln Pro Gln Gln Gln Leu Gln Pro Pro Ser Pro 
1               5                   10                  15      


Ala Pro Pro Asn His Val Val Thr Thr Ile Glu Asn Leu Pro Ala Glu 
            20                  25                  30          


Gly Ser Gly Gly Gly Gly Ser Leu Ser Ala Ser Ser Arg Ala Gly Val 
        35                  40                  45              


Arg Gln Arg Ile Arg Lys Val Leu Asn Arg Glu Met Leu Ile Ser Val 
    50                  55                  60                  


Ala Leu Gly Gln Val Leu Ser Leu Leu Ile Cys Gly Ile Gly Leu Thr 
65                  70                  75                  80  


Ser Lys Tyr Leu Ser Glu Asp Phe His Ala Asn Thr Pro Val Phe Gln 
                85                  90                  95      


Ser Phe Leu Asn Tyr Ile Leu Leu Phe Leu Val Tyr Thr Thr Thr Leu 
            100                 105                 110         


Ala Val Arg Gln Gly Glu Glu Asn Leu Leu Ala Ile Leu Arg Arg Arg 
        115                 120                 125             


Trp Trp Lys Tyr Met Ile Leu Gly Leu Ile Asp Leu Glu Ala Asn Tyr 
    130                 135                 140                 


Leu Val Val Lys Ala Tyr Gln Tyr Thr Thr Leu Thr Ser Ile Gln Leu 
145                 150                 155                 160 


Leu Asp Cys Phe Val Ile Pro Val Val Ile Leu Leu Ser Trp Phe Phe 
                165                 170                 175     


Leu Leu Ile Arg Tyr Lys Ala Val His Phe Ile Gly Ile Val Val Cys 
            180                 185                 190         


Ile Leu Gly Met Gly Cys Met Val Gly Ala Asp Val Leu Val Gly Arg 
        195                 200                 205             


His Gln Gly Ala Gly Glu Asn Lys Leu Val Gly Asp Leu Leu Val Leu 
    210                 215                 220                 


Gly Gly Ala Thr Leu Tyr Gly Ile Ser Asn Val Trp Glu Glu Tyr Ile 
225                 230                 235                 240 


Ile Arg Thr Leu Ser Arg Val Glu Phe Leu Gly Met Ile Gly Leu Phe 
                245                 250                 255     


Gly Ala Phe Phe Ser Gly Ile Gln Leu Ala Ile Met Glu His Lys Glu 
            260                 265                 270         


Leu Leu Lys Val Pro Trp Asp Trp Gln Ile Gly Leu Leu Tyr Val Gly 
        275                 280                 285             


Phe Ser Ala Cys Met Phe Gly Leu Tyr Ser Phe Met Pro Val Val Ile 
    290                 295                 300                 


Lys Lys Thr Ser Ala Thr Ser Val Asn Leu Ser Leu Leu Thr Ala Asp 
305                 310                 315                 320 


Leu Tyr Ser Leu Phe Cys Gly Leu Phe Leu Phe His Tyr Lys Phe Ser 
                325                 330                 335     


Gly Leu Tyr Leu Leu Ser Phe Phe Thr Ile Leu Ile Gly Leu Val Leu 
            340                 345                 350         


Tyr Ser Ser Thr Ser Thr Tyr Ile Ala Gln Asp Pro Arg Val Tyr Lys 
        355                 360                 365             


Gln Phe Arg Asn Pro Ser Gly Pro Val Val Asp Leu Pro Thr Thr Ala 
    370                 375                 380                 


Gln Val Glu Pro Ser Val Thr Tyr Thr Ser Leu Gly Gln Glu Thr Glu 
385                 390                 395                 400 


Glu Glu Pro His Val Arg Val Ala 
                405             


<210>  711
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  711

Met Ala Lys Met Phe Asp Leu Arg Thr Lys Ile Met Ile Gly Ile Gly 
1               5                   10                  15      


Ser Ser Leu Leu Val Ala Ala Met Val Leu Leu Ser Val Val Phe Cys 
            20                  25                  30          


Leu Tyr Phe Lys Val Ala Lys Ala Leu Lys Ala Ala Lys Asp Pro Asp 
        35                  40                  45              


Ala Val Ala Val Lys Asn His Asn Pro Asp Lys Val Cys Trp Ala Thr 
    50                  55                  60                  


Asn Ser Gln Ala Lys Ala Thr Thr Met Glu Ser Cys Pro Ser Leu Gln 
65                  70                  75                  80  


Cys Cys Glu Gly Cys Arg Met His Ala Ser Ser Asp Ser Leu Pro Pro 
                85                  90                  95      


Cys Cys Cys Asp Ile Asn Glu Gly Leu 
            100                 105 


<210>  712
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  712

Met Arg Leu Leu Glu Arg Met Arg Lys Asp Trp Phe Met Val Gly Ile 
1               5                   10                  15      


Val Leu Ala Ile Ala Gly Ala Lys Leu Glu Pro Ser Ile Gly Val Asn 
            20                  25                  30          


Gly Gly Pro Leu Lys Pro Glu Ile Thr Val Ser Tyr Ile Ala Val Ala 
        35                  40                  45              


Thr Ile Phe Phe Asn Ser Gly Leu Ser Leu Lys Thr Glu Glu Leu Thr 
    50                  55                  60                  


Ser Ala Leu Val His Leu Lys Leu His Leu Phe Ile Gln Ile Phe Thr 
65                  70                  75                  80  


Leu Ala Phe Phe Pro Ala Thr Ile Trp Leu Phe Leu Gln Leu Leu Ser 
                85                  90                  95      


Ile Thr Pro Ile Asn Glu Trp Leu Leu Lys Gly Leu Gln Thr Val Gly 
            100                 105                 110         


Cys Met Pro Pro Pro Val Ser Ser Ala Val Ile Leu Thr Lys Ala Val 
        115                 120                 125             


Gly Gly Asn Glu Ala Ala Ala Ile Phe Asn Ser Ala Phe Gly Ser Phe 
    130                 135                 140                 


Leu Gly Ile Val Ile Thr Pro Leu Leu Leu Leu Leu Phe Leu Gly Ser 
145                 150                 155                 160 


Ser Ser Ser Val Pro Phe Thr Ser Ile Phe Ser Gln Leu Phe Met Thr 
                165                 170                 175     


Val Val Val Pro Leu Ile Ile Gly Gln Ile Val Arg Arg Tyr Ile Lys 
            180                 185                 190         


Asp Trp Leu Glu Arg Lys Lys Pro Pro Phe Gly Ala Ile Ser Ser Ser 
        195                 200                 205             


Val Leu Leu Met Ile Ile Tyr Thr Thr Phe Cys Asp Thr Phe Ser Asn 
    210                 215                 220                 


Pro Asn Ile Asp Leu Asp Lys Phe Ser Leu Val Leu Ile Leu Phe Ile 
225                 230                 235                 240 


Ile Phe Ser Ile Gln Leu Ser Phe Met Leu Leu Thr Phe Ile Phe Ser 
                245                 250                 255     


Thr Arg Asn Asn Ser Gly Phe Thr Pro Ala Asp Thr Val Ala Ile Ile 
            260                 265                 270         


Phe Cys Ser Thr His Lys Ser Leu Thr Leu Gly Ile Pro Met Leu Lys 
        275                 280                 285             


Ile Val Phe Ala Gly His Glu His Leu Ser Leu Ile Ser Val Pro Leu 
    290                 295                 300                 


Leu Ile Tyr His Pro Ala Gln Ile Leu Leu Gly Ser Val Leu Val Pro 
305                 310                 315                 320 


Thr Ile Lys Ser Trp Met Val Ser Arg Gln Lys Gly Val Lys Leu Thr 
                325                 330                 335     


Arg Pro Thr Val 
            340 


<210>  713
<211>  489
<212>  PRT
<213>  Homo sapiens

<400>  713

Met Asn Pro Pro Ser Gly Pro Arg Val Pro Pro Ser Pro Thr Gln Glu 
1               5                   10                  15      


Pro Ser Cys Met Ala Thr Pro Ala Pro Pro Ser Trp Trp Asp Ser Ser 
            20                  25                  30          


Gln Ser Ser Ile Ser Ser Leu Gly Arg Leu Pro Ser Ile Ser Pro Thr 
        35                  40                  45              


Ala Pro Gly Thr Trp Ala Ala Ala Trp Val Pro Leu Pro Thr Val Asp 
    50                  55                  60                  


Val Pro Asp His Ala His Tyr Thr Leu Gly Thr Val Ile Leu Leu Val 
65                  70                  75                  80  


Gly Leu Thr Gly Met Leu Gly Asn Leu Thr Val Ile Tyr Thr Phe Cys 
                85                  90                  95      


Arg Ala Val Leu Arg Gly Val Thr Val Met Met Gln Ser Arg Ser Leu 
            100                 105                 110         


Arg Thr Pro Ala Asn Met Phe Ile Ile Asn Leu Ala Val Ser Asp Phe 
        115                 120                 125             


Leu Met Ser Phe Thr Gln Ala Pro Val Phe Phe Thr Ser Ser Leu Tyr 
    130                 135                 140                 


Lys Gln Trp Leu Phe Gly Glu Thr Gly Cys Glu Phe Tyr Ala Phe Cys 
145                 150                 155                 160 


Gly Ala Leu Phe Gly Ile Ser Ser Met Ile Thr Leu Thr Ala Ile Ala 
                165                 170                 175     


Leu Asp Arg Tyr Leu Val Ile Thr Arg Pro Leu Ala Thr Phe Gly Val 
            180                 185                 190         


Ala Ser Lys Arg Arg Ala Ala Phe Val Leu Leu Gly Val Trp Leu Tyr 
        195                 200                 205             


Ala Leu Ala Trp Ser Leu Pro Pro Phe Phe Gly Trp Ser Ala Tyr Val 
    210                 215                 220                 


Pro Glu Gly Leu Leu Thr Ser Cys Ser Trp Asp Tyr Met Ser Phe Thr 
225                 230                 235                 240 


Pro Ala Val Arg Ala Tyr Thr Met Leu Leu Cys Cys Phe Val Phe Phe 
                245                 250                 255     


Leu Pro Leu Leu Ile Ile Ile Tyr Cys Tyr Ile Phe Ile Phe Arg Ala 
            260                 265                 270         


Ile Arg Glu Thr Gly Arg Ala Leu Gln Thr Phe Gly Ala Cys Lys Gly 
        275                 280                 285             


Asn Gly Glu Ser Leu Trp Gln Arg Gln Arg Leu Gln Ser Glu Cys Lys 
    290                 295                 300                 


Met Ala Lys Ile Met Leu Leu Val Ile Leu Leu Phe Val Leu Ser Trp 
305                 310                 315                 320 


Ala Pro Tyr Ser Ala Val Ala Leu Val Ala Phe Ala Gly Tyr Ala His 
                325                 330                 335     


Val Leu Thr Pro Tyr Met Ser Ser Val Pro Ala Val Ile Ala Lys Ala 
            340                 345                 350         


Ser Ala Ile His Asn Pro Ile Ile Tyr Ala Ile Thr His Pro Lys Tyr 
        355                 360                 365             


Arg Val Ala Ile Ala Gln His Leu Pro Cys Leu Gly Val Leu Leu Gly 
    370                 375                 380                 


Val Ser Arg Arg His Ser Arg Pro Tyr Pro Ser Tyr Arg Ser Thr His 
385                 390                 395                 400 


Arg Ser Thr Leu Thr Ser His Thr Ser Asn Leu Ser Trp Ile Ser Ile 
                405                 410                 415     


Arg Arg Arg Gln Glu Ser Leu Gly Ser Glu Ser Glu Val Gly Trp Thr 
            420                 425                 430         


His Met Glu Ala Ala Ala Val Trp Gly Ala Ala Gln Gln Ala Asn Gly 
        435                 440                 445             


Arg Ser Leu Tyr Gly Gln Gly Leu Glu Asp Leu Glu Ala Lys Ala Pro 
    450                 455                 460                 


Pro Arg Pro Gln Gly His Glu Ala Glu Thr Pro Gly Lys Thr Lys Gly 
465                 470                 475                 480 


Leu Ile Pro Ser Gln Asp Pro Arg Met 
                485                 


<210>  714
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  714

Met Ala Leu Asn His Thr Ala Leu Pro Gln Asp Glu Arg Leu Pro His 
1               5                   10                  15      


Tyr Leu Arg Asp Gly Asp Pro Phe Ala Ser Lys Leu Ser Trp Glu Ala 
            20                  25                  30          


Asp Leu Val Ala Gly Phe Tyr Leu Thr Ile Ile Gly Ile Leu Ser Thr 
        35                  40                  45              


Phe Gly Asn Gly Tyr Val Leu Tyr Met Ser Ser Arg Arg Lys Lys Lys 
    50                  55                  60                  


Leu Arg Pro Ala Glu Ile Met Thr Ile Asn Leu Ala Val Cys Asp Leu 
65                  70                  75                  80  


Gly Ile Ser Val Val Gly Lys Pro Phe Thr Ile Ile Ser Cys Phe Cys 
                85                  90                  95      


His Arg Trp Val Phe Gly Trp Ile Gly Cys Arg Trp Tyr Gly Trp Ala 
            100                 105                 110         


Gly Phe Phe Phe Gly Cys Gly Ser Leu Ile Thr Met Thr Ala Val Ser 
        115                 120                 125             


Leu Asp Arg Tyr Leu Lys Ile Cys Tyr Leu Ser Tyr Gly Val Trp Leu 
    130                 135                 140                 


Lys Arg Lys His Ala Tyr Ile Cys Leu Ala Ala Ile Trp Ala Tyr Ala 
145                 150                 155                 160 


Ser Phe Trp Thr Thr Met Pro Leu Val Gly Leu Gly Asp Tyr Val Pro 
                165                 170                 175     


Glu Pro Phe Gly Thr Ser Cys Thr Leu Asp Trp Trp Leu Ala Gln Ala 
            180                 185                 190         


Ser Val Gly Gly Gln Val Phe Ile Leu Asn Ile Leu Phe Phe Cys Leu 
        195                 200                 205             


Leu Leu Pro Thr Ala Val Ile Val Phe Ser Tyr Val Lys Ile Ile Ala 
    210                 215                 220                 


Lys Val Lys Ser Ser Ser Lys Glu Val Ala His Phe Asp Ser Arg Ile 
225                 230                 235                 240 


His Ser Ser His Val Leu Glu Met Lys Leu Thr Lys Val Ala Met Leu 
                245                 250                 255     


Ile Cys Ala Gly Phe Leu Ile Ala Trp Ile Pro Tyr Ala Val Val Ser 
            260                 265                 270         


Val Trp Ser Ala Phe Gly Arg Pro Asp Ser Ile Pro Ile Gln Leu Ser 
        275                 280                 285             


Val Val Pro Thr Leu Leu Ala Lys Ser Ala Ala Met Tyr Asn Pro Ile 
    290                 295                 300                 


Ile Tyr Gln Val Ile Asp Tyr Lys Phe Ala Cys Cys Gln Thr Gly Gly 
305                 310                 315                 320 


Leu Lys Ala Thr Lys Lys Lys Ser Leu Glu Gly Phe Arg Leu His Thr 
                325                 330                 335     


Val Thr Thr Val Arg Lys Ser Ser Ala Val Leu Glu Ile His Glu Glu 
            340                 345                 350         


Trp Glu 
        


<210>  715
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  715

Met Arg Glu Leu Ala Ile Glu Ile Gly Val Arg Ala Leu Leu Phe Gly 
1               5                   10                  15      


Val Phe Val Phe Thr Glu Phe Leu Asp Pro Phe Gln Arg Val Ile Gln 
            20                  25                  30          


Pro Glu Glu Ile Trp Leu Tyr Lys Asn Pro Leu Val Gln Ser Asp Asn 
        35                  40                  45              


Ile Pro Thr Arg Leu Met Phe Ala Ile Ser Phe Leu Thr Pro Leu Ala 
    50                  55                  60                  


Val Ile Cys Val Val Lys Ile Ile Arg Arg Thr Asp Lys Thr Glu Ile 
65                  70                  75                  80  


Lys Glu Ala Phe Leu Ala Val Ser Leu Ala Leu Ala Leu Asn Gly Val 
                85                  90                  95      


Cys Thr Asn Thr Ile Lys Leu Ile Val Gly Arg Pro Arg Pro Asp Phe 
            100                 105                 110         


Phe Tyr Arg Cys Phe Pro Asp Gly Val Met Asn Ser Glu Met His Cys 
        115                 120                 125             


Thr Gly Asp Pro Asp Leu Val Ser Glu Gly Arg Lys Ser Phe Pro Ser 
    130                 135                 140                 


Ile His Ser Ser Phe Ala Phe Ser Gly Leu Gly Phe Thr Thr Phe Tyr 
145                 150                 155                 160 


Leu Ala Gly Lys Leu His Cys Phe Thr Glu Ser Gly Arg Gly Lys Ser 
                165                 170                 175     


Trp Arg Leu Cys Ala Ala Ile Leu Pro Leu Tyr Cys Ala Met Met Ile 
            180                 185                 190         


Ala Leu Ser Arg Met Cys Asp Tyr Lys His His Trp Gln Asp Ser Phe 
        195                 200                 205             


Val Gly Gly Val Ile Gly Leu Ile Phe Ala Tyr Ile Cys Tyr Arg Gln 
    210                 215                 220                 


His Tyr Pro Pro Leu Ala Asn Thr Ala Cys His Lys Pro Tyr Val Ser 
225                 230                 235                 240 


Leu Arg Val Pro Ala Ser Leu Lys Lys Glu Glu Arg Pro Thr Ala Asp 
                245                 250                 255     


Ser Ala Pro Ser Leu Pro Leu Glu Gly Ile Thr Glu Gly Pro Val 
            260                 265                 270     


<210>  716
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  716

Met Cys Thr Asn Ile Val Tyr Glu Trp Leu Lys Ala Leu Gln Leu Pro 
1               5                   10                  15      


Gln Tyr Ala Glu Ser Phe Val Asp Asn Gly Tyr Asp Asp Leu Glu Val 
            20                  25                  30          


Cys Lys Gln Ile Gly Asp Pro Asp Leu Asp Ala Ile Gly Val Leu Ala 
        35                  40                  45              


Pro Ala His Arg Arg Arg Ile Leu Glu Ala Val Arg Arg Leu Arg Glu 
    50                  55                  60                  


Gln Asp Ala Asn Ala Ala Gly Leu Tyr Phe Thr Leu Glu Pro Gln Pro 
65                  70                  75                  80  


Ala Pro Pro Gly Pro Pro Ala Asp Ala Val Pro Thr Gly Arg Arg Gly 
                85                  90                  95      


Glu Pro Cys Gly Gly Pro Ala Gln Gly Thr Arg Gly Asp Ser Arg Gly 
            100                 105                 110         


His Thr Thr Ala Pro Arg Ser Arg Glu Leu Val Ser Tyr Pro Lys Leu 
        115                 120                 125             


Lys Leu Lys Ile Met Ile Arg Asp Lys Leu Val Arg Asp Gly Ile His 
    130                 135                 140                 


Leu Ser Lys Pro Pro Tyr Ser Arg Lys Val Pro Met Ala Gly Ile Leu 
145                 150                 155                 160 


Glu Tyr Leu Met Asn Trp Pro Lys Ser Ser Gln Ser Arg 
                165                 170             


<210>  717
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  717

Met Ala Thr Leu Leu Leu Leu Leu Gly Val Leu Val Val Ser Pro Asp 
1               5                   10                  15      


Ala Leu Gly Ser Thr Thr Ala Val Gln Thr Pro Thr Ser Gly Glu Pro 
            20                  25                  30          


Leu Val Ser Thr Ser Glu Pro Leu Ser Ser Lys Met Tyr Thr Thr Ser 
        35                  40                  45              


Ile Thr Ser Asp Pro Lys Ala Asp Ser Thr Gly Asp Gln Thr Ser Ala 
    50                  55                  60                  


Leu Pro Pro Ser Thr Ser Ile Asn Glu Gly Ser Pro Leu Trp Thr Ser 
65                  70                  75                  80  


Ile Gly Ala Ser Thr Gly Ser Pro Leu Pro Glu Pro Thr Thr Tyr Gln 
                85                  90                  95      


Glu Val Ser Ile Lys Met Ser Ser Val Pro Gln Glu Thr Pro His Ala 
            100                 105                 110         


Thr Ser His Pro Ala Val Pro Ile Thr Ala Asn Ser Leu Gly Ser His 
        115                 120                 125             


Thr Val Thr Gly Gly Thr Ile Thr Thr Asn Ser Pro Glu Thr Ser Ser 
    130                 135                 140                 


Arg Thr Ser Gly Ala Pro Val Thr Thr Ala Ala Ser Ser Leu Glu Thr 
145                 150                 155                 160 


Ser Arg Gly Thr Ser Gly Pro Pro Leu Thr Met Ala Thr Val Ser Leu 
                165                 170                 175     


Glu Thr Ser Lys Gly Thr Ser Gly Pro Pro Val Thr Met Ala Thr Asp 
            180                 185                 190         


Ser Leu Glu Thr Ser Thr Gly Thr Thr Gly Pro Pro Val Thr Met Thr 
        195                 200                 205             


Thr Gly Ser Leu Glu Pro Ser Ser Gly Ala Ser Gly Pro Gln Val Ser 
    210                 215                 220                 


Ser Val Lys Leu Ser Thr Met Met Ser Pro Thr Thr Ser Thr Asn Ala 
225                 230                 235                 240 


Ser Thr Val Pro Phe Arg Asn Pro Asp Glu Asn Ser Arg Gly Met Leu 
                245                 250                 255     


Pro Val Ala Val Leu Val Ala Leu Leu Ala Val Ile Val Leu Val Ala 
            260                 265                 270         


Leu Leu Leu Leu Trp Arg Arg Arg Gln Lys Arg Arg Thr Gly Ala Leu 
        275                 280                 285             


Val Leu Ser Arg Gly Gly Lys Arg Asn Gly Val Val Asp Ala Trp Ala 
    290                 295                 300                 


Gly Pro Ala Gln Val Pro Glu Glu Gly Ala Val Thr Val Thr Val Gly 
305                 310                 315                 320 


Gly Ser Gly Gly Asp Lys Gly Ser Gly Phe Pro Asp Gly Glu Gly Ser 
                325                 330                 335     


Ser Arg Arg Pro Thr Leu Thr Thr Phe Phe Gly Arg Arg Lys Ser Arg 
            340                 345                 350         


Gln Gly Ser Leu Ala Met Glu Glu Leu Lys Ser Gly Ser Gly Pro Ser 
        355                 360                 365             


Leu Lys Gly Glu Glu Glu Pro Leu Val Ala Ser Glu Asp Gly Ala Val 
    370                 375                 380                 


Asp Ala Pro Ala Pro Asp Glu Pro Glu Gly Gly Asp Gly Ala Ala Pro 
385                 390                 395                 400 


<210>  718
<211>  4967
<212>  PRT
<213>  Homo sapiens

<400>  718

Met Ala Asp Gly Gly Glu Gly Glu Asp Glu Ile Gln Phe Leu Arg Thr 
1               5                   10                  15      


Asp Asp Glu Val Val Leu Gln Cys Thr Ala Thr Ile His Lys Glu Gln 
            20                  25                  30          


Gln Lys Leu Cys Leu Ala Ala Glu Gly Phe Gly Asn Arg Leu Cys Phe 
        35                  40                  45              


Leu Glu Ser Thr Ser Asn Ser Lys Asn Val Pro Pro Asp Leu Ser Ile 
    50                  55                  60                  


Cys Thr Phe Val Leu Glu Gln Ser Leu Ser Val Arg Ala Leu Gln Glu 
65                  70                  75                  80  


Met Leu Ala Asn Thr Val Glu Lys Ser Glu Gly Gln Val Asp Val Glu 
                85                  90                  95      


Lys Trp Lys Phe Met Met Lys Thr Ala Gln Gly Gly Gly His Arg Thr 
            100                 105                 110         


Leu Leu Tyr Gly His Ala Ile Leu Leu Arg His Ser Tyr Ser Gly Met 
        115                 120                 125             


Tyr Leu Cys Cys Leu Ser Thr Ser Arg Ser Ser Thr Asp Lys Leu Ala 
    130                 135                 140                 


Phe Asp Val Gly Leu Gln Glu Asp Thr Thr Gly Glu Ala Cys Trp Trp 
145                 150                 155                 160 


Thr Ile His Pro Ala Ser Lys Gln Arg Ser Glu Gly Glu Lys Val Arg 
                165                 170                 175     


Val Gly Asp Asp Leu Ile Leu Val Ser Val Ser Ser Glu Arg Tyr Leu 
            180                 185                 190         


His Leu Ser Tyr Gly Asn Gly Ser Leu His Val Asp Ala Ala Phe Gln 
        195                 200                 205             


Gln Thr Leu Trp Ser Val Ala Pro Ile Ser Ser Gly Ser Glu Ala Ala 
    210                 215                 220                 


Gln Gly Tyr Leu Ile Gly Gly Asp Val Leu Arg Leu Leu His Gly His 
225                 230                 235                 240 


Met Asp Glu Cys Leu Thr Val Pro Ser Gly Glu His Gly Glu Glu Gln 
                245                 250                 255     


Arg Arg Thr Val His Tyr Glu Gly Gly Ala Val Ser Val His Ala Arg 
            260                 265                 270         


Ser Leu Trp Arg Leu Glu Thr Leu Arg Val Ala Trp Ser Gly Ser His 
        275                 280                 285             


Ile Arg Trp Gly Gln Pro Phe Arg Leu Arg His Val Thr Thr Gly Lys 
    290                 295                 300                 


Tyr Leu Ser Leu Met Glu Asp Lys Asn Leu Leu Leu Met Asp Lys Glu 
305                 310                 315                 320 


Lys Ala Asp Val Lys Ser Thr Ala Phe Thr Phe Arg Ser Ser Lys Glu 
                325                 330                 335     


Lys Leu Asp Val Gly Val Arg Lys Glu Val Asp Gly Met Gly Thr Ser 
            340                 345                 350         


Glu Ile Lys Tyr Gly Asp Ser Val Cys Tyr Ile Gln His Val Asp Thr 
        355                 360                 365             


Gly Leu Trp Leu Thr Tyr Gln Ser Val Asp Val Lys Ser Val Arg Met 
    370                 375                 380                 


Gly Ser Ile Gln Arg Lys Ala Ile Met His His Glu Gly His Met Asp 
385                 390                 395                 400 


Asp Gly Ile Ser Leu Ser Arg Ser Gln His Glu Glu Ser Arg Thr Ala 
                405                 410                 415     


Arg Val Ile Arg Ser Thr Val Phe Leu Phe Asn Arg Phe Ile Arg Gly 
            420                 425                 430         


Leu Asp Ala Leu Ser Lys Lys Ala Lys Ala Ser Thr Val Asp Leu Pro 
        435                 440                 445             


Ile Glu Ser Val Ser Leu Ser Leu Gln Asp Leu Ile Gly Tyr Phe His 
    450                 455                 460                 


Pro Pro Asp Glu His Leu Glu His Glu Asp Lys Gln Asn Arg Leu Arg 
465                 470                 475                 480 


Ala Leu Lys Asn Arg Gln Asn Leu Phe Gln Glu Glu Gly Met Ile Asn 
                485                 490                 495     


Leu Val Leu Glu Cys Ile Asp Arg Leu His Val Tyr Ser Ser Ala Ala 
            500                 505                 510         


His Phe Ala Asp Val Ala Gly Arg Glu Ala Gly Glu Ser Trp Lys Ser 
        515                 520                 525             


Ile Leu Asn Ser Leu Tyr Glu Leu Leu Ala Ala Leu Ile Arg Gly Asn 
    530                 535                 540                 


Arg Lys Asn Cys Ala Gln Phe Ser Gly Ser Leu Asp Trp Leu Ile Ser 
545                 550                 555                 560 


Arg Leu Glu Arg Leu Glu Ala Ser Ser Gly Ile Leu Glu Val Leu His 
                565                 570                 575     


Cys Val Leu Val Glu Ser Pro Glu Ala Leu Asn Ile Ile Lys Glu Gly 
            580                 585                 590         


His Ile Lys Ser Ile Ile Ser Leu Leu Asp Lys His Gly Arg Asn His 
        595                 600                 605             


Lys Val Leu Asp Val Leu Cys Ser Leu Cys Val Cys His Gly Val Ala 
    610                 615                 620                 


Val Arg Ser Asn Gln His Leu Ile Cys Asp Asn Leu Leu Pro Gly Arg 
625                 630                 635                 640 


Asp Leu Leu Leu Gln Thr Arg Leu Val Asn His Val Ser Ser Met Arg 
                645                 650                 655     


Pro Asn Ile Phe Leu Gly Val Ser Glu Gly Ser Ala Gln Tyr Lys Lys 
            660                 665                 670         


Trp Tyr Tyr Glu Leu Met Val Asp His Thr Glu Pro Phe Val Thr Ala 
        675                 680                 685             


Glu Ala Thr His Leu Arg Val Gly Trp Ala Ser Thr Glu Gly Tyr Ser 
    690                 695                 700                 


Pro Tyr Pro Gly Gly Gly Glu Glu Trp Gly Gly Asn Gly Val Gly Asp 
705                 710                 715                 720 


Asp Leu Phe Ser Tyr Gly Phe Asp Gly Leu His Leu Trp Ser Gly Cys 
                725                 730                 735     


Ile Ala Arg Thr Val Ser Ser Pro Asn Gln His Leu Leu Arg Thr Asp 
            740                 745                 750         


Asp Val Ile Ser Cys Cys Leu Asp Leu Ser Ala Pro Ser Ile Ser Phe 
        755                 760                 765             


Arg Ile Asn Gly Gln Pro Val Gln Gly Met Phe Glu Asn Phe Asn Ile 
    770                 775                 780                 


Asp Gly Leu Phe Phe Pro Val Val Ser Phe Ser Ala Gly Ile Lys Val 
785                 790                 795                 800 


Arg Phe Leu Leu Gly Gly Arg His Gly Glu Phe Lys Phe Leu Pro Pro 
                805                 810                 815     


Pro Gly Tyr Ala Pro Cys Tyr Glu Ala Val Leu Pro Lys Glu Lys Leu 
            820                 825                 830         


Lys Val Glu His Ser Arg Glu Tyr Lys Gln Glu Arg Thr Tyr Thr Arg 
        835                 840                 845             


Asp Leu Leu Gly Pro Thr Val Ser Leu Thr Gln Ala Ala Phe Thr Pro 
    850                 855                 860                 


Ile Pro Val Asp Thr Ser Gln Ile Val Leu Pro Pro His Leu Glu Arg 
865                 870                 875                 880 


Ile Arg Glu Lys Leu Ala Glu Asn Ile His Glu Leu Trp Val Met Asn 
                885                 890                 895     


Lys Ile Glu Leu Gly Trp Gln Tyr Gly Pro Val Arg Asp Asp Asn Lys 
            900                 905                 910         


Arg Gln His Pro Cys Leu Val Glu Phe Ser Lys Leu Pro Glu Gln Glu 
        915                 920                 925             


Arg Asn Tyr Asn Leu Gln Met Ser Leu Glu Thr Leu Lys Thr Leu Leu 
    930                 935                 940                 


Ala Leu Gly Cys His Val Gly Ile Ser Asp Glu His Ala Glu Asp Lys 
945                 950                 955                 960 


Val Lys Lys Met Lys Leu Pro Lys Asn Tyr Gln Leu Thr Ser Gly Tyr 
                965                 970                 975     


Lys Pro Ala Pro Met Asp Leu Ser Phe Ile Lys Leu Thr Pro Ser Gln 
            980                 985                 990         


Glu Ala Met Val Asp Lys Leu Ala  Glu Asn Ala His Asn  Val Trp Ala 
        995                 1000                 1005             


Arg Asp  Arg Ile Arg Gln Gly  Trp Thr Tyr Gly Ile  Gln Gln Asp 
    1010                 1015                 1020             


Val Lys  Asn Arg Arg Asn Pro  Arg Leu Val Pro Tyr  Thr Leu Leu 
    1025                 1030                 1035             


Asp Asp  Arg Thr Lys Lys Ser  Asn Lys Asp Ser Leu  Arg Glu Ala 
    1040                 1045                 1050             


Val Arg  Thr Leu Leu Gly Tyr  Gly Tyr Asn Leu Glu  Ala Pro Asp 
    1055                 1060                 1065             


Gln Asp  His Ala Ala Arg Ala  Glu Val Cys Ser Gly  Thr Gly Glu 
    1070                 1075                 1080             


Arg Phe  Arg Ile Phe Arg Ala  Glu Lys Thr Tyr Ala  Val Lys Ala 
    1085                 1090                 1095             


Gly Arg  Trp Tyr Phe Glu Phe  Glu Thr Val Thr Ala  Gly Asp Met 
    1100                 1105                 1110             


Arg Val  Gly Trp Ser Arg Pro  Gly Cys Gln Pro Asp  Gln Glu Leu 
    1115                 1120                 1125             


Gly Ser  Asp Glu Arg Ala Phe  Ala Phe Asp Gly Phe  Lys Ala Gln 
    1130                 1135                 1140             


Arg Trp  His Gln Gly Asn Glu  His Tyr Gly Arg Ser  Trp Gln Ala 
    1145                 1150                 1155             


Gly Asp  Val Val Gly Cys Met  Val Asp Met Asn Glu  His Thr Met 
    1160                 1165                 1170             


Met Phe  Thr Leu Asn Gly Glu  Ile Leu Leu Asp Asp  Ser Gly Ser 
    1175                 1180                 1185             


Glu Leu  Ala Phe Lys Asp Phe  Asp Val Gly Asp Gly  Phe Ile Pro 
    1190                 1195                 1200             


Val Cys  Ser Leu Gly Val Ala  Gln Val Gly Arg Met  Asn Phe Gly 
    1205                 1210                 1215             


Lys Asp  Val Ser Thr Leu Lys  Tyr Phe Thr Ile Cys  Gly Leu Gln 
    1220                 1225                 1230             


Glu Gly  Tyr Glu Pro Phe Ala  Val Asn Thr Asn Arg  Asp Ile Thr 
    1235                 1240                 1245             


Met Trp  Leu Ser Lys Arg Leu  Pro Gln Phe Leu Gln  Val Pro Ser 
    1250                 1255                 1260             


Asn His  Glu His Ile Glu Val  Thr Arg Ile Asp Gly  Thr Ile Asp 
    1265                 1270                 1275             


Ser Ser  Pro Cys Leu Lys Val  Thr Gln Lys Ser Phe  Gly Ser Gln 
    1280                 1285                 1290             


Asn Ser  Asn Thr Asp Ile Met  Phe Tyr Arg Leu Ser  Met Pro Ile 
    1295                 1300                 1305             


Glu Cys  Ala Glu Val Phe Ser  Lys Thr Val Ala Gly  Gly Leu Pro 
    1310                 1315                 1320             


Gly Ala  Gly Leu Phe Gly Pro  Lys Asn Asp Leu Glu  Asp Tyr Asp 
    1325                 1330                 1335             


Ala Asp  Ser Asp Phe Glu Val  Leu Met Lys Thr Ala  His Gly His 
    1340                 1345                 1350             


Leu Val  Pro Asp Arg Val Asp  Lys Asp Lys Glu Ala  Thr Lys Pro 
    1355                 1360                 1365             


Glu Phe  Asn Asn His Lys Asp  Tyr Ala Gln Glu Lys  Pro Ser Arg 
    1370                 1375                 1380             


Leu Lys  Gln Arg Phe Leu Leu  Arg Arg Thr Lys Pro  Asp Tyr Ser 
    1385                 1390                 1395             


Thr Ser  His Ser Ala Arg Leu  Thr Glu Asp Val Leu  Ala Asp Asp 
    1400                 1405                 1410             


Arg Asp  Asp Tyr Asp Phe Leu  Met Gln Thr Ser Thr  Tyr Tyr Tyr 
    1415                 1420                 1425             


Ser Val  Arg Ile Phe Pro Gly  Gln Glu Pro Ala Asn  Val Trp Val 
    1430                 1435                 1440             


Gly Trp  Ile Thr Ser Asp Phe  His Gln Tyr Asp Thr  Gly Phe Asp 
    1445                 1450                 1455             


Leu Asp  Arg Val Arg Thr Val  Thr Val Thr Leu Gly  Asp Glu Lys 
    1460                 1465                 1470             


Gly Lys  Val His Glu Ser Ile  Lys Arg Ser Asn Cys  Tyr Met Val 
    1475                 1480                 1485             


Cys Ala  Gly Glu Ser Met Ser  Pro Gly Gln Gly Arg  Asn Asn Asn 
    1490                 1495                 1500             


Gly Leu  Glu Ile Gly Cys Val  Val Asp Ala Ala Ser  Gly Leu Leu 
    1505                 1510                 1515             


Thr Phe  Ile Ala Asn Gly Lys  Glu Leu Ser Thr Tyr  Tyr Gln Val 
    1520                 1525                 1530             


Glu Pro  Ser Thr Lys Leu Phe  Pro Ala Val Phe Ala  Gln Ala Thr 
    1535                 1540                 1545             


Ser Pro  Asn Val Phe Gln Phe  Glu Leu Gly Arg Ile  Lys Asn Val 
    1550                 1555                 1560             


Met Pro  Leu Ser Ala Gly Leu  Phe Lys Ser Glu His  Lys Asn Pro 
    1565                 1570                 1575             


Val Pro  Gln Cys Pro Pro Arg  Leu His Val Gln Phe  Leu Ser His 
    1580                 1585                 1590             


Val Leu  Trp Ser Arg Met Pro  Asn Gln Phe Leu Lys  Val Asp Val 
    1595                 1600                 1605             


Ser Arg  Ile Ser Glu Arg Gln  Gly Trp Leu Val Gln  Cys Leu Asp 
    1610                 1615                 1620             


Pro Leu  Gln Phe Met Ser Leu  His Ile Pro Glu Glu  Asn Arg Ser 
    1625                 1630                 1635             


Val Asp  Ile Leu Glu Leu Thr  Glu Gln Glu Glu Leu  Leu Lys Phe 
    1640                 1645                 1650             


His Tyr  His Thr Leu Arg Leu  Tyr Ser Ala Val Cys  Ala Leu Gly 
    1655                 1660                 1665             


Asn His  Arg Val Ala His Ala  Leu Cys Ser His Val  Asp Glu Pro 
    1670                 1675                 1680             


Gln Leu  Leu Tyr Ala Ile Glu  Asn Lys Tyr Met Pro  Gly Leu Leu 
    1685                 1690                 1695             


Arg Ala  Gly Tyr Tyr Asp Leu  Leu Ile Asp Ile His  Leu Ser Ser 
    1700                 1705                 1710             


Tyr Ala  Thr Ala Arg Leu Met  Met Asn Asn Glu Tyr  Ile Val Pro 
    1715                 1720                 1725             


Met Thr  Glu Glu Thr Lys Ser  Ile Thr Leu Phe Pro  Asp Glu Asn 
    1730                 1735                 1740             


Lys Lys  His Gly Leu Pro Gly  Ile Gly Leu Ser Thr  Ser Leu Arg 
    1745                 1750                 1755             


Pro Arg  Met Gln Phe Ser Ser  Pro Ser Phe Val Ser  Ile Ser Asn 
    1760                 1765                 1770             


Glu Cys  Tyr Gln Tyr Ser Pro  Glu Phe Pro Leu Asp  Ile Leu Lys 
    1775                 1780                 1785             


Ser Lys  Thr Ile Gln Met Leu  Thr Glu Ala Val Lys  Glu Gly Ser 
    1790                 1795                 1800             


Leu His  Ala Arg Asp Pro Val  Gly Gly Thr Thr Glu  Phe Leu Phe 
    1805                 1810                 1815             


Val Pro  Leu Ile Lys Leu Phe  Tyr Thr Leu Leu Ile  Met Gly Ile 
    1820                 1825                 1830             


Phe His  Asn Glu Asp Leu Lys  His Ile Leu Gln Leu  Ile Glu Pro 
    1835                 1840                 1845             


Ser Val  Phe Lys Glu Ala Ala  Thr Pro Glu Glu Glu  Ser Asp Thr 
    1850                 1855                 1860             


Leu Glu  Lys Glu Leu Ser Val  Asp Asp Ala Lys Leu  Gln Gly Ala 
    1865                 1870                 1875             


Gly Glu  Glu Glu Ala Lys Gly  Gly Lys Arg Pro Lys  Glu Gly Leu 
    1880                 1885                 1890             


Leu Gln  Met Lys Leu Pro Glu  Pro Val Lys Leu Gln  Met Cys Leu 
    1895                 1900                 1905             


Leu Leu  Gln Tyr Leu Cys Asp  Cys Gln Val Arg His  Arg Ile Glu 
    1910                 1915                 1920             


Ala Ile  Val Ala Phe Ser Asp  Asp Phe Val Ala Lys  Leu Gln Asp 
    1925                 1930                 1935             


Asn Gln  Arg Phe Arg Tyr Asn  Glu Val Met Gln Ala  Leu Asn Met 
    1940                 1945                 1950             


Ser Ala  Ala Leu Thr Ala Arg  Lys Thr Lys Glu Phe  Arg Ser Pro 
    1955                 1960                 1965             


Pro Gln  Glu Gln Ile Asn Met  Leu Leu Asn Phe Lys  Asp Asp Lys 
    1970                 1975                 1980             


Ser Glu  Cys Pro Cys Pro Glu  Glu Ile Arg Asp Gln  Leu Leu Asp 
    1985                 1990                 1995             


Phe His  Glu Asp Leu Met Thr  His Cys Gly Ile Glu  Leu Asp Glu 
    2000                 2005                 2010             


Asp Gly  Ser Leu Asp Gly Asn  Ser Asp Leu Thr Ile  Arg Gly Arg 
    2015                 2020                 2025             


Leu Leu  Ser Leu Val Glu Lys  Val Thr Tyr Leu Lys  Lys Lys Gln 
    2030                 2035                 2040             


Ala Glu  Lys Pro Val Glu Ser  Asp Ser Lys Lys Ser  Ser Thr Leu 
    2045                 2050                 2055             


Gln Gln  Leu Ile Ser Glu Thr  Met Val Arg Trp Ala  Gln Glu Ser 
    2060                 2065                 2070             


Val Ile  Glu Asp Pro Glu Leu  Val Arg Ala Met Phe  Val Leu Leu 
    2075                 2080                 2085             


His Arg  Gln Tyr Asp Gly Ile  Gly Gly Leu Val Arg  Ala Leu Pro 
    2090                 2095                 2100             


Lys Thr  Tyr Thr Ile Asn Gly  Val Ser Val Glu Asp  Thr Ile Asn 
    2105                 2110                 2115             


Leu Leu  Ala Ser Leu Gly Gln  Ile Arg Ser Leu Leu  Ser Val Arg 
    2120                 2125                 2130             


Met Gly  Lys Glu Glu Glu Lys  Leu Met Ile Arg Gly  Leu Gly Asp 
    2135                 2140                 2145             


Ile Met  Asn Asn Lys Val Phe  Tyr Gln His Pro Asn  Leu Met Arg 
    2150                 2155                 2160             


Ala Leu  Gly Met His Glu Thr  Val Met Glu Val Met  Val Asn Val 
    2165                 2170                 2175             


Leu Gly  Gly Gly Glu Ser Lys  Glu Ile Thr Phe Pro  Lys Met Val 
    2180                 2185                 2190             


Ala Asn  Cys Cys Arg Phe Leu  Cys Tyr Phe Cys Arg  Ile Ser Arg 
    2195                 2200                 2205             


Gln Asn  Gln Lys Ala Met Phe  Asp His Leu Ser Tyr  Leu Leu Glu 
    2210                 2215                 2220             


Asn Ser  Ser Val Gly Leu Ala  Ser Pro Ala Met Arg  Gly Ser Thr 
    2225                 2230                 2235             


Pro Leu  Asp Val Ala Ala Ala  Ser Val Met Asp Asn  Asn Glu Leu 
    2240                 2245                 2250             


Ala Leu  Ala Leu Arg Glu Pro  Asp Leu Glu Lys Val  Val Arg Tyr 
    2255                 2260                 2265             


Leu Ala  Gly Cys Gly Leu Gln  Ser Cys Gln Met Leu  Val Ser Lys 
    2270                 2275                 2280             


Gly Tyr  Pro Asp Ile Gly Trp  Asn Pro Val Glu Gly  Glu Arg Tyr 
    2285                 2290                 2295             


Leu Asp  Phe Leu Arg Phe Ala  Val Phe Cys Asn Gly  Glu Ser Val 
    2300                 2305                 2310             


Glu Glu  Asn Ala Asn Val Val  Val Arg Leu Leu Ile  Arg Arg Pro 
    2315                 2320                 2325             


Glu Cys  Phe Gly Pro Ala Leu  Arg Gly Glu Gly Gly  Asn Gly Leu 
    2330                 2335                 2340             


Leu Ala  Ala Met Glu Glu Ala  Ile Lys Ile Ala Glu  Asp Pro Ser 
    2345                 2350                 2355             


Arg Asp  Gly Pro Ser Pro Asn  Ser Gly Ser Ser Lys  Thr Leu Asp 
    2360                 2365                 2370             


Thr Glu  Glu Glu Glu Asp Asp  Thr Ile His Met Gly  Asn Ala Ile 
    2375                 2380                 2385             


Met Thr  Phe Tyr Ser Ala Leu  Ile Asp Leu Leu Gly  Arg Cys Ala 
    2390                 2395                 2400             


Pro Glu  Met His Leu Ile His  Ala Gly Lys Gly Glu  Ala Ile Arg 
    2405                 2410                 2415             


Ile Arg  Ser Ile Leu Arg Ser  Leu Ile Pro Leu Gly  Asp Leu Val 
    2420                 2425                 2430             


Gly Val  Ile Ser Ile Ala Phe  Gln Met Pro Thr Ile  Ala Lys Asp 
    2435                 2440                 2445             


Gly Asn  Val Val Glu Pro Asp  Met Ser Ala Gly Phe  Cys Pro Asp 
    2450                 2455                 2460             


His Lys  Ala Ala Met Val Leu  Phe Leu Asp Arg Val  Tyr Gly Ile 
    2465                 2470                 2475             


Glu Val  Gln Asp Phe Leu Leu  His Leu Leu Glu Val  Gly Phe Leu 
    2480                 2485                 2490             


Pro Asp  Leu Arg Ala Ala Ala  Ser Leu Asp Thr Ala  Ala Leu Ser 
    2495                 2500                 2505             


Ala Thr  Asp Met Ala Leu Ala  Leu Asn Arg Tyr Leu  Cys Thr Ala 
    2510                 2515                 2520             


Val Leu  Pro Leu Leu Thr Arg  Cys Ala Pro Leu Phe  Ala Gly Thr 
    2525                 2530                 2535             


Glu His  His Ala Ser Leu Ile  Asp Ser Leu Leu His  Thr Val Tyr 
    2540                 2545                 2550             


Arg Leu  Ser Lys Gly Cys Ser  Leu Thr Lys Ala Gln  Arg Asp Ser 
    2555                 2560                 2565             


Ile Glu  Val Cys Leu Leu Ser  Ile Cys Gly Gln Leu  Arg Pro Ser 
    2570                 2575                 2580             


Met Met  Gln His Leu Leu Arg  Arg Leu Val Phe Asp  Val Pro Leu 
    2585                 2590                 2595             


Leu Asn  Glu His Ala Lys Met  Pro Leu Lys Leu Leu  Thr Asn His 
    2600                 2605                 2610             


Tyr Glu  Arg Cys Trp Lys Tyr  Tyr Cys Leu Pro Gly  Gly Trp Gly 
    2615                 2620                 2625             


Asn Phe  Gly Ala Ala Ser Glu  Glu Glu Leu His Leu  Ser Arg Lys 
    2630                 2635                 2640             


Leu Phe  Trp Gly Ile Phe Asp  Ala Leu Ser Gln Lys  Lys Tyr Glu 
    2645                 2650                 2655             


Gln Glu  Leu Phe Lys Leu Ala  Leu Pro Cys Leu Ser  Ala Val Ala 
    2660                 2665                 2670             


Gly Ala  Leu Pro Pro Asp Tyr  Met Glu Ser Asn Tyr  Val Ser Met 
    2675                 2680                 2685             


Met Glu  Lys Gln Ser Ser Met  Asp Ser Glu Gly Asn  Phe Asn Pro 
    2690                 2695                 2700             


Gln Pro  Val Asp Thr Ser Asn  Ile Thr Ile Pro Glu  Lys Leu Glu 
    2705                 2710                 2715             


Tyr Phe  Ile Asn Lys Tyr Ala  Glu His Ser His Asp  Lys Trp Ser 
    2720                 2725                 2730             


Met Asp  Lys Leu Ala Asn Gly  Trp Ile Tyr Gly Glu  Ile Tyr Ser 
    2735                 2740                 2745             


Asp Ser  Ser Lys Val Gln Pro  Leu Met Lys Pro Tyr  Lys Leu Leu 
    2750                 2755                 2760             


Ser Glu  Lys Glu Lys Glu Ile  Tyr Arg Trp Pro Ile  Lys Glu Ser 
    2765                 2770                 2775             


Leu Lys  Thr Met Leu Ala Trp  Gly Trp Arg Ile Glu  Arg Thr Arg 
    2780                 2785                 2790             


Glu Gly  Asp Ser Met Ala Leu  Tyr Asn Arg Thr Arg  Arg Ile Ser 
    2795                 2800                 2805             


Gln Thr  Ser Gln Val Ser Val  Asp Ala Ala His Gly  Tyr Ser Pro 
    2810                 2815                 2820             


Arg Ala  Ile Asp Met Ser Asn  Val Thr Leu Ser Arg  Asp Leu His 
    2825                 2830                 2835             


Ala Met  Ala Glu Met Met Ala  Glu Asn Tyr His Asn  Ile Trp Ala 
    2840                 2845                 2850             


Lys Lys  Lys Lys Met Glu Leu  Glu Ser Lys Gly Gly  Gly Asn His 
    2855                 2860                 2865             


Pro Leu  Leu Val Pro Tyr Asp  Thr Leu Thr Ala Lys  Glu Lys Ala 
    2870                 2875                 2880             


Lys Asp  Arg Glu Lys Ala Gln  Asp Ile Leu Lys Phe  Leu Gln Ile 
    2885                 2890                 2895             


Asn Gly  Tyr Ala Val Ser Arg  Gly Phe Lys Asp Leu  Glu Leu Asp 
    2900                 2905                 2910             


Thr Pro  Ser Ile Glu Lys Arg  Phe Ala Tyr Ser Phe  Leu Gln Gln 
    2915                 2920                 2925             


Leu Ile  Arg Tyr Val Asp Glu  Ala His Gln Tyr Ile  Leu Glu Phe 
    2930                 2935                 2940             


Asp Gly  Gly Ser Arg Gly Lys  Gly Glu His Phe Pro  Tyr Glu Gln 
    2945                 2950                 2955             


Glu Ile  Lys Phe Phe Ala Lys  Val Val Leu Pro Leu  Ile Asp Gln 
    2960                 2965                 2970             


Tyr Phe  Lys Asn His Arg Leu  Tyr Phe Leu Ser Ala  Ala Ser Arg 
    2975                 2980                 2985             


Pro Leu  Cys Ser Gly Gly His  Ala Ser Asn Lys Glu  Lys Glu Met 
    2990                 2995                 3000             


Val Thr  Ser Leu Phe Cys Lys  Leu Gly Val Leu Val  Arg His Arg 
    3005                 3010                 3015             


Ile Ser  Leu Phe Gly Asn Asp  Ala Thr Ser Ile Val  Asn Cys Leu 
    3020                 3025                 3030             


His Ile  Leu Gly Gln Thr Leu  Asp Ala Arg Thr Val  Met Lys Thr 
    3035                 3040                 3045             


Gly Leu  Glu Ser Val Lys Ser  Ala Leu Arg Ala Phe  Leu Asp Asn 
    3050                 3055                 3060             


Ala Ala  Glu Asp Leu Glu Lys  Thr Met Glu Asn Leu  Lys Gln Gly 
    3065                 3070                 3075             


Gln Phe  Thr His Thr Arg Asn  Gln Pro Lys Gly Val  Thr Gln Ile 
    3080                 3085                 3090             


Ile Asn  Tyr Thr Thr Val Ala  Leu Leu Pro Met Leu  Ser Ser Leu 
    3095                 3100                 3105             


Phe Glu  His Ile Gly Gln His  Gln Phe Gly Glu Asp  Leu Ile Leu 
    3110                 3115                 3120             


Glu Asp  Val Gln Val Ser Cys  Tyr Arg Ile Leu Thr  Ser Leu Tyr 
    3125                 3130                 3135             


Ala Leu  Gly Thr Ser Lys Ser  Ile Tyr Val Glu Arg  Gln Arg Ser 
    3140                 3145                 3150             


Ala Leu  Gly Glu Cys Leu Ala  Ala Phe Ala Gly Ala  Phe Pro Val 
    3155                 3160                 3165             


Ala Phe  Leu Glu Thr His Leu  Asp Lys His Asn Ile  Tyr Ser Ile 
    3170                 3175                 3180             


Tyr Asn  Thr Lys Ser Ser Arg  Glu Arg Ala Ala Leu  Ser Leu Pro 
    3185                 3190                 3195             


Thr Asn  Val Glu Asp Val Cys  Pro Asn Ile Pro Ser  Leu Glu Lys 
    3200                 3205                 3210             


Leu Met  Glu Glu Ile Val Glu  Leu Ala Glu Ser Gly  Ile Arg Tyr 
    3215                 3220                 3225             


Thr Gln  Met Pro His Val Met  Glu Val Ile Leu Pro  Met Leu Cys 
    3230                 3235                 3240             


Ser Tyr  Met Ser Arg Trp Trp  Glu His Gly Pro Glu  Asn Asn Pro 
    3245                 3250                 3255             


Glu Arg  Ala Glu Met Cys Cys  Thr Ala Leu Asn Ser  Glu His Met 
    3260                 3265                 3270             


Asn Thr  Leu Leu Gly Asn Ile  Leu Lys Ile Ile Tyr  Asn Asn Leu 
    3275                 3280                 3285             


Gly Ile  Asp Glu Gly Ala Trp  Met Lys Arg Leu Ala  Val Phe Ser 
    3290                 3295                 3300             


Gln Pro  Ile Ile Asn Lys Val  Lys Pro Gln Leu Leu  Lys Thr His 
    3305                 3310                 3315             


Phe Leu  Pro Leu Met Glu Lys  Leu Lys Lys Lys Ala  Ala Thr Val 
    3320                 3325                 3330             


Val Ser  Glu Glu Asp His Leu  Lys Ala Glu Ala Arg  Gly Asp Met 
    3335                 3340                 3345             


Ser Glu  Ala Glu Leu Leu Ile  Leu Asp Glu Phe Thr  Thr Leu Ala 
    3350                 3355                 3360             


Arg Asp  Leu Tyr Ala Phe Tyr  Pro Leu Leu Ile Arg  Phe Val Asp 
    3365                 3370                 3375             


Tyr Asn  Arg Ala Lys Trp Leu  Lys Glu Pro Asn Pro  Glu Ala Glu 
    3380                 3385                 3390             


Glu Leu  Phe Arg Met Val Ala  Glu Val Phe Ile Tyr  Trp Ser Lys 
    3395                 3400                 3405             


Ser His  Asn Phe Lys Arg Glu  Glu Gln Asn Phe Val  Val Gln Asn 
    3410                 3415                 3420             


Glu Ile  Asn Asn Met Ser Phe  Leu Ile Thr Asp Thr  Lys Ser Lys 
    3425                 3430                 3435             


Met Ser  Lys Ala Ala Val Ser  Asp Gln Glu Arg Lys  Lys Met Lys 
    3440                 3445                 3450             


Arg Lys  Gly Asp Arg Tyr Ser  Met Gln Thr Ser Leu  Ile Val Ala 
    3455                 3460                 3465             


Ala Leu  Lys Arg Leu Leu Pro  Ile Gly Leu Asn Ile  Cys Ala Pro 
    3470                 3475                 3480             


Gly Asp  Gln Glu Leu Ile Ala  Leu Ala Lys Asn Arg  Phe Ser Leu 
    3485                 3490                 3495             


Lys Asp  Thr Glu Asp Glu Val  Arg Asp Ile Ile Arg  Ser Asn Ile 
    3500                 3505                 3510             


His Leu  Gln Gly Lys Leu Glu  Asp Pro Ala Ile Arg  Trp Gln Met 
    3515                 3520                 3525             


Ala Leu  Tyr Lys Asp Leu Pro  Asn Arg Thr Asp Asp  Thr Ser Asp 
    3530                 3535                 3540             


Pro Glu  Lys Thr Val Glu Arg  Val Leu Asp Ile Ala  Asn Val Leu 
    3545                 3550                 3555             


Phe His  Leu Glu Gln Lys Ser  Lys Arg Val Gly Arg  Arg His Tyr 
    3560                 3565                 3570             


Cys Leu  Val Glu His Pro Gln  Arg Ser Lys Lys Ala  Val Trp His 
    3575                 3580                 3585             


Lys Leu  Leu Ser Lys Gln Arg  Lys Arg Ala Val Val  Ala Cys Phe 
    3590                 3595                 3600             


Arg Met  Ala Pro Leu Tyr Asn  Leu Pro Arg His Arg  Ala Val Asn 
    3605                 3610                 3615             


Leu Phe  Leu Gln Gly Tyr Glu  Lys Ser Trp Ile Glu  Thr Glu Glu 
    3620                 3625                 3630             


His Tyr  Phe Glu Asp Lys Leu  Ile Glu Asp Leu Ala  Lys Pro Gly 
    3635                 3640                 3645             


Ala Glu  Pro Pro Glu Glu Asp  Glu Gly Thr Lys Arg  Val Asp Pro 
    3650                 3655                 3660             


Leu His  Gln Leu Ile Leu Leu  Phe Ser Arg Thr Ala  Leu Thr Glu 
    3665                 3670                 3675             


Lys Cys  Lys Leu Glu Glu Asp  Phe Leu Tyr Met Ala  Tyr Ala Asp 
    3680                 3685                 3690             


Ile Met  Ala Lys Ser Cys His  Asp Glu Glu Asp Asp  Asp Gly Glu 
    3695                 3700                 3705             


Glu Glu  Val Lys Ser Phe Glu  Glu Lys Glu Met Glu  Lys Gln Lys 
    3710                 3715                 3720             


Leu Leu  Tyr Gln Gln Ala Arg  Leu His Asp Arg Gly  Ala Ala Glu 
    3725                 3730                 3735             


Met Val  Leu Gln Thr Ile Ser  Ala Ser Lys Gly Glu  Thr Gly Pro 
    3740                 3745                 3750             


Met Val  Ala Ala Thr Leu Lys  Leu Gly Ile Ala Ile  Leu Asn Gly 
    3755                 3760                 3765             


Gly Asn  Ser Thr Val Gln Gln  Lys Met Leu Asp Tyr  Leu Lys Glu 
    3770                 3775                 3780             


Lys Lys  Asp Val Gly Phe Phe  Gln Ser Leu Ala Gly  Leu Met Gln 
    3785                 3790                 3795             


Ser Cys  Ser Val Leu Asp Leu  Asn Ala Phe Glu Arg  Gln Asn Lys 
    3800                 3805                 3810             


Ala Glu  Gly Leu Gly Met Val  Thr Glu Glu Gly Ser  Gly Glu Lys 
    3815                 3820                 3825             


Val Leu  Gln Asp Asp Glu Phe  Thr Cys Asp Leu Phe  Arg Phe Leu 
    3830                 3835                 3840             


Gln Leu  Leu Cys Glu Gly His  Asn Ser Asp Phe Gln  Asn Tyr Leu 
    3845                 3850                 3855             


Arg Thr  Gln Thr Gly Asn Asn  Thr Thr Val Asn Ile  Ile Ile Ser 
    3860                 3865                 3870             


Thr Val  Asp Tyr Leu Leu Arg  Val Gln Glu Ser Ile  Ser Asp Phe 
    3875                 3880                 3885             


Tyr Trp  Tyr Tyr Ser Gly Lys  Asp Val Ile Asp Glu  Gln Gly Gln 
    3890                 3895                 3900             


Arg Asn  Phe Ser Lys Ala Ile  Gln Val Ala Lys Gln  Val Phe Asn 
    3905                 3910                 3915             


Thr Leu  Thr Glu Tyr Ile Gln  Gly Pro Cys Thr Gly  Asn Gln Gln 
    3920                 3925                 3930             


Ser Leu  Ala His Ser Arg Leu  Trp Asp Ala Val Val  Gly Phe Leu 
    3935                 3940                 3945             


His Val  Phe Ala His Met Gln  Met Lys Leu Ser Gln  Asp Ser Ser 
    3950                 3955                 3960             


Gln Ile  Glu Leu Leu Lys Glu  Leu Met Asp Leu Gln  Lys Asp Met 
    3965                 3970                 3975             


Val Val  Met Leu Leu Ser Met  Leu Glu Gly Asn Val  Val Asn Gly 
    3980                 3985                 3990             


Thr Ile  Gly Lys Gln Met Val  Asp Met Leu Val Glu  Ser Ser Asn 
    3995                 4000                 4005             


Asn Val  Glu Met Ile Leu Lys  Phe Phe Asp Met Phe  Leu Lys Leu 
    4010                 4015                 4020             


Lys Asp  Leu Thr Ser Ser Asp  Thr Phe Lys Glu Tyr  Asp Pro Asp 
    4025                 4030                 4035             


Gly Lys  Gly Val Ile Ser Lys  Arg Asp Phe His Lys  Ala Met Glu 
    4040                 4045                 4050             


Ser His  Lys His Tyr Thr Gln  Ser Glu Thr Glu Phe  Leu Leu Ser 
    4055                 4060                 4065             


Cys Ala  Glu Thr Asp Glu Asn  Glu Thr Leu Asp Tyr  Glu Glu Phe 
    4070                 4075                 4080             


Val Lys  Arg Phe His Glu Pro  Ala Lys Asp Ile Gly  Phe Asn Val 
    4085                 4090                 4095             


Ala Val  Leu Leu Thr Asn Leu  Ser Glu His Met Pro  Asn Asp Thr 
    4100                 4105                 4110             


Arg Leu  Gln Thr Phe Leu Glu  Leu Ala Glu Ser Val  Leu Asn Tyr 
    4115                 4120                 4125             


Phe Gln  Pro Phe Leu Gly Arg  Ile Glu Ile Met Gly  Ser Ala Lys 
    4130                 4135                 4140             


Arg Ile  Glu Arg Val Tyr Phe  Glu Ile Ser Glu Ser  Ser Arg Thr 
    4145                 4150                 4155             


Gln Trp  Glu Lys Pro Gln Val  Lys Glu Ser Lys Arg  Gln Phe Ile 
    4160                 4165                 4170             


Phe Asp  Val Val Asn Glu Gly  Gly Glu Lys Glu Lys  Met Glu Leu 
    4175                 4180                 4185             


Phe Val  Asn Phe Cys Glu Asp  Thr Ile Phe Glu Met  Gln Leu Ala 
    4190                 4195                 4200             


Ala Gln  Ile Ser Glu Ser Asp  Leu Asn Glu Arg Ser  Ala Asn Lys 
    4205                 4210                 4215             


Glu Glu  Ser Glu Lys Glu Arg  Pro Glu Glu Gln Gly  Pro Arg Met 
    4220                 4225                 4230             


Ala Phe  Phe Ser Ile Leu Thr  Val Arg Ser Ala Leu  Phe Ala Leu 
    4235                 4240                 4245             


Arg Tyr  Asn Ile Leu Thr Leu  Met Arg Met Leu Ser  Leu Lys Ser 
    4250                 4255                 4260             


Leu Lys  Lys Gln Met Lys Lys  Val Lys Lys Met Thr  Val Lys Asp 
    4265                 4270                 4275             


Met Val  Thr Ala Phe Phe Ser  Ser Tyr Trp Ser Ile  Phe Met Thr 
    4280                 4285                 4290             


Leu Leu  His Phe Val Ala Ser  Val Phe Arg Gly Phe  Phe Arg Ile 
    4295                 4300                 4305             


Ile Cys  Ser Leu Leu Leu Gly  Gly Ser Leu Val Glu  Gly Ala Lys 
    4310                 4315                 4320             


Lys Ile  Lys Val Ala Glu Leu  Leu Ala Asn Met Pro  Asp Pro Thr 
    4325                 4330                 4335             


Gln Asp  Glu Val Arg Gly Asp  Gly Glu Glu Gly Glu  Arg Lys Pro 
    4340                 4345                 4350             


Leu Glu  Ala Ala Leu Pro Ser  Glu Asp Leu Thr Asp  Leu Lys Glu 
    4355                 4360                 4365             


Leu Thr  Glu Glu Ser Asp Leu  Leu Ser Asp Ile Phe  Gly Leu Asp 
    4370                 4375                 4380             


Leu Lys  Arg Glu Gly Gly Gln  Tyr Lys Leu Ile Pro  His Asn Pro 
    4385                 4390                 4395             


Asn Ala  Gly Leu Ser Asp Leu  Met Ser Asn Pro Val  Pro Met Pro 
    4400                 4405                 4410             


Glu Val  Gln Glu Lys Phe Gln  Glu Gln Lys Ala Lys  Glu Glu Glu 
    4415                 4420                 4425             


Lys Glu  Glu Lys Glu Glu Thr  Lys Ser Glu Pro Glu  Lys Ala Glu 
    4430                 4435                 4440             


Gly Glu  Asp Gly Glu Lys Glu  Glu Lys Ala Lys Glu  Asp Lys Gly 
    4445                 4450                 4455             


Lys Gln  Lys Leu Arg Gln Leu  His Thr His Arg Tyr  Gly Glu Pro 
    4460                 4465                 4470             


Glu Val  Pro Glu Ser Ala Phe  Trp Lys Lys Ile Ile  Ala Tyr Gln 
    4475                 4480                 4485             


Gln Lys  Leu Leu Asn Tyr Phe  Ala Arg Asn Phe Tyr  Asn Met Arg 
    4490                 4495                 4500             


Met Leu  Ala Leu Phe Val Ala  Phe Ala Ile Asn Phe  Ile Leu Leu 
    4505                 4510                 4515             


Phe Tyr  Lys Val Ser Thr Ser  Ser Val Val Glu Gly  Lys Glu Leu 
    4520                 4525                 4530             


Pro Thr  Arg Ser Ser Ser Glu  Asn Ala Lys Val Thr  Ser Leu Asp 
    4535                 4540                 4545             


Ser Ser  Ser His Arg Ile Ile  Ala Val His Tyr Val  Leu Glu Glu 
    4550                 4555                 4560             


Ser Ser  Gly Tyr Met Glu Pro  Thr Leu Arg Ile Leu  Ala Ile Leu 
    4565                 4570                 4575             


His Thr  Val Ile Ser Phe Phe  Cys Ile Ile Gly Tyr  Tyr Cys Leu 
    4580                 4585                 4590             


Lys Val  Pro Leu Val Ile Phe  Lys Arg Glu Lys Glu  Val Ala Arg 
    4595                 4600                 4605             


Lys Leu  Glu Phe Asp Gly Leu  Tyr Ile Thr Glu Gln  Pro Ser Glu 
    4610                 4615                 4620             


Asp Asp  Ile Lys Gly Gln Trp  Asp Arg Leu Val Ile  Asn Thr Gln 
    4625                 4630                 4635             


Ser Phe  Pro Asn Asn Tyr Trp  Asp Lys Phe Val Lys  Arg Lys Val 
    4640                 4645                 4650             


Met Asp  Lys Tyr Gly Glu Phe  Tyr Gly Arg Asp Arg  Ile Ser Glu 
    4655                 4660                 4665             


Leu Leu  Gly Met Asp Lys Ala  Ala Leu Asp Phe Ser  Asp Ala Arg 
    4670                 4675                 4680             


Glu Lys  Lys Lys Pro Lys Lys  Asp Ser Ser Leu Ser  Ala Val Leu 
    4685                 4690                 4695             


Asn Ser  Ile Asp Val Lys Tyr  Gln Met Trp Lys Leu  Gly Val Val 
    4700                 4705                 4710             


Phe Thr  Asp Asn Ser Phe Leu  Tyr Leu Ala Trp Tyr  Met Thr Met 
    4715                 4720                 4725             


Ser Val  Leu Gly His Tyr Asn  Asn Phe Phe Phe Ala  Ala His Leu 
    4730                 4735                 4740             


Leu Asp  Ile Ala Met Gly Phe  Lys Thr Leu Arg Thr  Ile Leu Ser 
    4745                 4750                 4755             


Ser Val  Thr His Asn Gly Lys  Gln Leu Val Leu Thr  Val Gly Leu 
    4760                 4765                 4770             


Leu Ala  Val Val Val Tyr Leu  Tyr Thr Val Val Ala  Phe Asn Phe 
    4775                 4780                 4785             


Phe Arg  Lys Phe Tyr Asn Lys  Ser Glu Asp Gly Asp  Thr Pro Asp 
    4790                 4795                 4800             


Met Lys  Cys Asp Asp Met Leu  Thr Cys Tyr Met Phe  His Met Tyr 
    4805                 4810                 4815             


Val Gly  Val Arg Ala Gly Gly  Gly Ile Gly Asp Glu  Ile Glu Asp 
    4820                 4825                 4830             


Pro Ala  Gly Asp Glu Tyr Glu  Ile Tyr Arg Ile Ile  Phe Asp Ile 
    4835                 4840                 4845             


Thr Phe  Phe Phe Phe Val Ile  Val Ile Leu Leu Ala  Ile Ile Gln 
    4850                 4855                 4860             


Gly Leu  Ile Ile Asp Ala Phe  Gly Glu Leu Arg Asp  Gln Gln Glu 
    4865                 4870                 4875             


Gln Val  Lys Glu Asp Met Glu  Thr Lys Cys Phe Ile  Cys Gly Ile 
    4880                 4885                 4890             


Gly Asn  Asp Tyr Phe Asp Thr  Val Pro His Gly Phe  Glu Thr His 
    4895                 4900                 4905             


Thr Leu  Gln Glu His Asn Leu  Ala Asn Tyr Leu Phe  Phe Leu Met 
    4910                 4915                 4920             


Tyr Leu  Ile Asn Lys Asp Glu  Thr Glu His Thr Gly  Gln Glu Ser 
    4925                 4930                 4935             


Tyr Val  Trp Lys Met Tyr Gln  Glu Arg Cys Trp Glu  Phe Phe Pro 
    4940                 4945                 4950             


Ala Gly  Asp Cys Phe Arg Lys  Gln Tyr Glu Asp Gln  Leu Asn 
    4955                 4960                 4965         


<210>  719
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  719

Met Thr Ser Leu Leu Thr Thr Pro Ser Pro Arg Glu Glu Leu Met Thr 
1               5                   10                  15      


Thr Pro Ile Leu Gln Pro Thr Glu Ala Leu Ser Pro Glu Asp Gly Ala 
            20                  25                  30          


Ser Thr Ala Leu Ile Ala Val Val Ile Thr Val Val Phe Leu Thr Leu 
        35                  40                  45              


Leu Ser Val Val Ile Leu Ile Phe Phe Tyr Leu Tyr Lys Asn Lys Gly 
    50                  55                  60                  


Ser Tyr Val Thr Tyr Glu Pro Thr Glu Gly Glu Pro Ser Ala Ile Val 
65                  70                  75                  80  


Gln Met Glu Ser Asp Leu Ala Lys Gly Ser Glu Lys Glu Glu Tyr Phe 
                85                  90                  95      


Ile 
    


<210>  720
<211>  651
<212>  PRT
<213>  Homo sapiens

<400>  720

Met Leu Arg Glu Glu Ala Thr Lys Lys Ser Lys Glu Lys Glu Pro Gly 
1               5                   10                  15      


Met Ala Leu Pro Gln Gly Arg Leu Thr Phe Arg Asp Val Ala Ile Glu 
            20                  25                  30          


Phe Ser Leu Glu Glu Trp Lys Cys Leu Asn Pro Ala Gln Arg Ala Leu 
        35                  40                  45              


Tyr Arg Ala Val Met Leu Glu Asn Tyr Arg Asn Leu Glu Phe Val Asp 
    50                  55                  60                  


Ser Ser Leu Lys Ser Met Met Glu Phe Ser Ser Thr Arg His Ser Ile 
65                  70                  75                  80  


Thr Gly Glu Val Ile His Thr Gly Thr Leu Gln Arg His Lys Ser His 
                85                  90                  95      


His Ile Gly Asp Phe Cys Phe Pro Glu Met Lys Lys Asp Ile His His 
            100                 105                 110         


Phe Glu Phe Gln Trp Gln Glu Val Glu Arg Asn Gly His Glu Ala Pro 
        115                 120                 125             


Met Thr Lys Ile Lys Lys Leu Thr Gly Ser Thr Asp Arg Ser Asp His 
    130                 135                 140                 


Arg His Ala Gly Asn Lys Pro Ile Lys Asp Gln Leu Gly Leu Ser Phe 
145                 150                 155                 160 


His Ser His Leu Pro Glu Leu His Met Phe Gln Thr Lys Gly Lys Ile 
                165                 170                 175     


Ser Asn Gln Leu Asp Lys Ser Ile Gly Ala Ser Ser Ala Ser Glu Ser 
            180                 185                 190         


Gln Arg Ile Ser Cys Arg Leu Lys Thr His Ile Ser Asn Lys Tyr Gly 
        195                 200                 205             


Lys Asn Phe Leu His Ser Ser Phe Thr Gln Ile Gln Glu Ile Cys Met 
    210                 215                 220                 


Arg Glu Lys Pro Cys Gln Ser Asn Glu Cys Gly Lys Ala Phe Asn Tyr 
225                 230                 235                 240 


Ser Ser Leu Leu Arg Arg His His Ile Thr His Ser Arg Glu Arg Glu 
                245                 250                 255     


Tyr Lys Cys Asp Val Cys Gly Lys Ile Phe Asn Gln Lys Gln Tyr Ile 
            260                 265                 270         


Val Tyr His His Arg Cys His Thr Gly Glu Lys Thr Tyr Lys Cys Asn 
        275                 280                 285             


Glu Cys Gly Lys Thr Phe Thr Gln Met Ser Ser Leu Val Cys His Arg 
    290                 295                 300                 


Arg Leu His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys 
305                 310                 315                 320 


Thr Phe Ser Glu Lys Ser Ser Leu Arg Cys His Arg Arg Leu His Thr 
                325                 330                 335     


Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Thr Phe Gly Arg 
            340                 345                 350         


Asn Ser Ala Leu Val Ile His Lys Ala Ile His Thr Gly Glu Lys Pro 
        355                 360                 365             


Tyr Lys Cys Asn Glu Cys Gly Lys Thr Phe Ser Gln Lys Ser Ser Leu 
    370                 375                 380                 


Gln Cys His His Ile Leu His Thr Gly Glu Lys Pro Tyr Lys Cys Glu 
385                 390                 395                 400 


Glu Cys Asp Asn Val Tyr Ile Arg Arg Ser His Leu Glu Arg His Arg 
                405                 410                 415     


Lys Ile His Thr Gly Glu Gly Ser Tyr Lys Cys Lys Val Cys Asp Lys 
            420                 425                 430         


Val Phe Arg Ser Asp Ser Tyr Leu Ala Glu His Gln Arg Val His Thr 
        435                 440                 445             


Gly Glu Lys Pro Tyr Lys Cys Asn Lys Cys Gly Arg Ser Phe Ser Arg 
    450                 455                 460                 


Lys Ser Ser Leu Gln Tyr His His Thr Leu His Thr Gly Glu Lys Pro 
465                 470                 475                 480 


Tyr Thr Cys Asn Glu Cys Gly Lys Val Phe Ser Arg Arg Glu Asn Leu 
                485                 490                 495     


Ala Arg His His Arg Leu His Ala Gly Glu Lys Pro Tyr Lys Cys Glu 
            500                 505                 510         


Glu Cys Asp Lys Val Phe Ser Arg Arg Ser His Leu Glu Arg His Arg 
        515                 520                 525             


Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Val Cys Asp Lys 
    530                 535                 540                 


Ala Phe Arg Ser Asp Ser Cys Leu Ala Asn His Thr Arg Val His Thr 
545                 550                 555                 560 


Gly Glu Lys Pro Tyr Lys Cys Asn Lys Cys Ala Lys Val Phe Asn Gln 
                565                 570                 575     


Lys Gly Ile Leu Ala Gln His Gln Arg Val His Thr Gly Glu Lys Pro 
            580                 585                 590         


Tyr Lys Cys Asn Glu Cys Gly Lys Val Phe Asn Gln Lys Ala Ser Leu 
        595                 600                 605             


Ala Lys His Gln Arg Val His Thr Ala Glu Lys Pro Tyr Lys Cys Asn 
    610                 615                 620                 


Glu Cys Gly Lys Ala Phe Thr Gly Gln Ser Thr Leu Ile His His Gln 
625                 630                 635                 640 


Ala Ile His Gly Cys Arg Glu Thr Leu Gln Met 
                645                 650     


<210>  721
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  721

Met Asn Ile Ala Ser Ala Thr Ile Ala Leu Val Gly Thr Ala Phe Leu 
1               5                   10                  15      


Ser Leu Asn Ile Ala Val Asn Ile Gln Ser Leu Arg Ser Cys His Ser 
            20                  25                  30          


Ser Ser Glu Ser Pro Asp Leu Cys Asn Tyr Met Gly Ser Ile Ser Asn 
        35                  40                  45              


Gly Met Val Ser Leu Leu Leu Ile Leu Thr Leu Leu Glu Leu Cys Val 
    50                  55                  60                  


Thr Ile Ser Thr Ile Ala Met Trp Cys Asn Ala Asn Cys Cys Asn Ser 
65                  70                  75                  80  


Arg Glu Glu Ile Ser Ser Pro Pro Asn Ser Val 
                85                  90      


<210>  722
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  722

Met Ile Arg Asn Trp Leu Thr Ile Phe Ile Leu Phe Pro Leu Lys Leu 
1               5                   10                  15      


Val Glu Lys Cys Glu Ser Ser Val Ser Leu Thr Val Pro Pro Val Val 
            20                  25                  30          


Lys Leu Glu Asn Gly Ser Ser Thr Asn Val Ser Leu Thr Leu Arg Pro 
        35                  40                  45              


Pro Leu Asn Ala Thr Leu Val Ile Thr Phe Glu Ile Thr Phe Arg Ser 
    50                  55                  60                  


Lys Asn Ile Thr Ile Leu Glu Leu Pro Asp Glu Val Val Val Pro Pro 
65                  70                  75                  80  


Gly Val Thr Asn Ser Ser Phe Gln Val Thr Ser Gln Asn Val Gly Gln 
                85                  90                  95      


Leu Thr Val Tyr Leu His Gly Asn His Ser Asn Gln Thr Gly Pro Arg 
            100                 105                 110         


Ile Arg Phe Leu Val Ile Arg Ser Ser Ala Ile Ser Ile Ile Asn Gln 
        115                 120                 125             


Val Ile Gly Trp Ile Tyr Phe Val Ala Trp Ser Ile Ser Phe Tyr Pro 
    130                 135                 140                 


Gln Val Ile Met Asn Trp Arg Arg Lys Ser Val Ile Gly Leu Ser Phe 
145                 150                 155                 160 


Asp Phe Val Ala Leu Asn Leu Thr Gly Phe Val Ala Tyr Ser Val Phe 
                165                 170                 175     


Asn Ile Gly Leu Leu Trp Val Pro Tyr Ile Lys Glu Gln Phe Leu Leu 
            180                 185                 190         


Lys Tyr Pro Asn Gly Val Asn Pro Val Asn Ser Asn Asp Val Phe Phe 
        195                 200                 205             


Ser Leu His Ala Val Val Leu Thr Leu Ile Ile Ile Val Gln Cys Cys 
    210                 215                 220                 


Leu Tyr Glu Arg Gly Gly Gln Arg Val Ser Trp Pro Ala Ile Gly Phe 
225                 230                 235                 240 


Leu Val Leu Ala Trp Leu Phe Ala Phe Val Thr Met Ile Val Ala Ala 
                245                 250                 255     


Val Gly Val Thr Thr Trp Leu Gln Phe Leu Phe Cys Phe Ser Tyr Ile 
            260                 265                 270         


Lys Leu Ala Val Thr Leu Val Lys Tyr Phe Pro Gln Ala Tyr Met Asn 
        275                 280                 285             


Phe Tyr Tyr Lys Ser Thr Glu Gly Trp Ser Ile Gly Asn Val Leu Leu 
    290                 295                 300                 


Asp Phe Thr Gly Gly Ser Phe Ser Leu Leu Gln Met Phe Leu Gln Ser 
305                 310                 315                 320 


Tyr Asn Asn Asp Gln Trp Thr Leu Ile Phe Gly Asp Pro Thr Lys Phe 
                325                 330                 335     


Gly Leu Gly Val Phe Ser Ile Val Phe Asp Val Val Phe Phe Ile Gln 
            340                 345                 350         


His Phe Cys Leu Tyr Arg Lys Arg Pro Gly Leu Gln Ala Ala Arg Thr 
        355                 360                 365             


Gly Ser Gly Ser Arg Leu Arg Gln Asp Trp Ala Pro Ser Leu Gln Pro 
    370                 375                 380                 


Lys Ala Leu Pro Gln Thr Thr Ser Val Ser Ala Ser Ser Leu Lys Gly 
385                 390                 395                 400 


<210>  723
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  723

Met Lys Pro Lys Leu Met Tyr Gln Glu Leu Lys Val Pro Ala Glu Glu 
1               5                   10                  15      


Pro Ala Asn Glu Leu Pro Met Asn Glu Ile Glu Ala Trp Lys Ala Ala 
            20                  25                  30          


Glu Lys Lys Ala Arg Trp Val Leu Leu Val Leu Ile Leu Ala Val Val 
        35                  40                  45              


Gly Phe Gly Ala Leu Met Thr Gln Leu Phe Leu Trp Glu Tyr Gly Asp 
    50                  55                  60                  


Leu His Leu Phe Gly Pro Asn Gln Arg Pro Ala Pro Cys Tyr Asp Pro 
65                  70                  75                  80  


Cys Glu Ala Val Leu Val Glu Ser Ile Pro Glu Gly Leu Asp Phe Pro 
                85                  90                  95      


Asn Ala Ser Thr Gly Asn Pro Ser Thr Ser Gln Ala Trp Leu Gly Leu 
            100                 105                 110         


Leu Ala Gly Ala His Ser Ser Leu Asp Ile Ala Ser Phe Tyr Trp Thr 
        115                 120                 125             


Leu Thr Asn Asn Asp Thr His Thr Gln Glu Pro Ser Ala Gln Gln Gly 
    130                 135                 140                 


Glu Glu Val Leu Arg Gln Leu Gln Thr Leu Ala Pro Lys Gly Val Asn 
145                 150                 155                 160 


Val Arg Ile Ala Val Ser Lys Pro Ser Gly Pro Gln Pro Gln Ala Asp 
                165                 170                 175     


Leu Gln Ala Leu Leu Gln Ser Gly Ala Gln Val Arg Met Val Asp Met 
            180                 185                 190         


Gln Lys Leu Thr His Gly Val Leu His Thr Lys Phe Trp Val Val Asp 
        195                 200                 205             


Gln Thr His Phe Tyr Leu Gly Ser Ala Asn Met Asp Trp Arg Ser Leu 
    210                 215                 220                 


Thr Gln Val Lys Glu Leu Gly Val Val Met Tyr Asn Cys Ser Cys Leu 
225                 230                 235                 240 


Ala Arg Asp Leu Thr Lys Ile Phe Glu Ala Tyr Trp Phe Leu Gly Gln 
                245                 250                 255     


Ala Gly Ser Ser Ile Pro Ser Thr Trp Pro Arg Phe Tyr Asp Thr Arg 
            260                 265                 270         


Tyr Asn Gln Glu Thr Pro Met Glu Ile Cys Leu Asn Gly Thr Pro Ala 
        275                 280                 285             


Leu Ala Tyr Leu Ala Ser Ala Pro Pro Pro Leu Cys Pro Ser Gly Arg 
    290                 295                 300                 


Thr Pro Asp Leu Lys Ala Leu Leu Asn Val Val Asp Asn Ala Arg Ser 
305                 310                 315                 320 


Phe Ile Tyr Val Ala Val Met Asn Tyr Leu Pro Thr Leu Glu Phe Ser 
                325                 330                 335     


His Pro His Arg Phe Trp Pro Ala Ile Asp Asp Gly Leu Arg Arg Ala 
            340                 345                 350         


Thr Tyr Glu Arg Gly Val Lys Val Arg Leu Leu Ile Ser Cys Trp Gly 
        355                 360                 365             


His Ser Glu Pro Ser Met Arg Ala Phe Leu Leu Ser Leu Ala Ala Leu 
    370                 375                 380                 


Arg Asp Asn His Thr His Ser Asp Ile Gln Val Lys Leu Phe Val Val 
385                 390                 395                 400 


Pro Ala Asp Glu Ala Gln Ala Arg Ile Pro Tyr Ala Arg Val Asn His 
                405                 410                 415     


Asn Lys Tyr Met Val Thr Glu Arg Ala Thr Tyr Ile Gly Thr Ser Asn 
            420                 425                 430         


Trp Ser Gly Asn Tyr Phe Thr Glu Thr Ala Gly Thr Ser Leu Leu Val 
        435                 440                 445             


Thr Gln Asn Gly Arg Gly Gly Leu Arg Ser Gln Leu Glu Ala Ile Phe 
    450                 455                 460                 


Leu Arg Asp Trp Asp Ser Pro Tyr Ser His Asp Leu Asp Thr Ser Ala 
465                 470                 475                 480 


Asp Ser Val Gly Asn Ala Cys Arg Leu Leu 
                485                 490 


<210>  724
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  724

Met Thr Cys Pro Asp Lys Pro Gly Gln Leu Ile Asn Trp Phe Ile Cys 
1               5                   10                  15      


Ser Leu Cys Val Pro Arg Val Arg Lys Leu Trp Ser Ser Arg Arg Pro 
            20                  25                  30          


Arg Thr Arg Arg Asn Leu Leu Leu Gly Thr Ala Cys Ala Ile Tyr Leu 
        35                  40                  45              


Gly Phe Leu Val Ser Gln Val Gly Arg Ala Ser Leu Gln His Gly Gln 
    50                  55                  60                  


Ala Ala Glu Lys Gly Pro His Arg Ser Arg Asp Thr Ala Glu Pro Ser 
65                  70                  75                  80  


Phe Pro Glu Ile Pro Leu Asp Gly Thr Leu Ala Pro Pro Glu Ser Gln 
                85                  90                  95      


Gly Asn Gly Ser Thr Leu Gln Pro Asn Val Val Tyr Ile Thr Leu Arg 
            100                 105                 110         


Ser Lys Arg Ser Lys Pro Ala Asn Ile Arg Gly Thr Val Lys Pro Lys 
        115                 120                 125             


Arg Arg Lys Lys His Ala Val Ala Ser Ala Ala Pro Gly Gln Glu Ala 
    130                 135                 140                 


Leu Val Gly Pro Ser Leu Gln Pro Gln Glu Ala Ala Arg Glu Ala Asp 
145                 150                 155                 160 


Ala Val Ala Pro Gly Tyr Ala Gln Gly Ala Asn Leu Val Lys Ile Gly 
                165                 170                 175     


Glu Arg Pro Trp Arg Leu Val Arg Gly Pro Gly Val Arg Ala Gly Gly 
            180                 185                 190         


Pro Asp Phe Leu Gln Pro Ser Ser Arg Glu Ser Asn Ile Arg Ile Tyr 
        195                 200                 205             


Ser Glu Ser Ala Pro Ser Trp Leu Ser Lys Asp Asp Ile Arg Arg Met 
    210                 215                 220                 


Arg Leu Leu Ala Asp Ser Ala Val Ala Gly Leu Arg Pro Val Ser Ser 
225                 230                 235                 240 


Arg Ser Gly Ala Arg Leu Leu Val Leu Glu Gly Gly Ala Pro Gly Ala 
                245                 250                 255     


Val Leu Arg Cys Gly Pro Ser Pro Cys Gly Leu Leu Lys Gln Pro Leu 
            260                 265                 270         


Asp Met Ser Glu Val Phe Ala Phe His Leu Asp Arg Ile Leu Gly Leu 
        275                 280                 285             


Asn Arg Thr Leu Pro Ser Val Ser Arg Lys Ala Glu Phe Ile Gln Ala 
    290                 295                 300                 


Ala Ala Ala Ala Cys Leu Ser Met Arg Leu Ala Phe Phe Ile Phe Pro 
305                 310                 315                 320 


Ala Trp Glu Asp Met Arg Val Pro Gly Lys Cys Cys Ile Gly His Ala 
                325                 330                 335     


Arg Leu Thr Trp Gly Thr Tyr Gln Gln Leu Leu Lys Gln Lys Cys Trp 
            340                 345                 350         


Gln Asn Gly Arg Val Pro Lys Pro Glu Ser Gly Cys Thr Glu Ile His 
        355                 360                 365             


His His Glu Trp Ser Lys Met Ala Leu Phe Asp Phe Leu Leu Gln Ile 
    370                 375                 380                 


Tyr Asn Arg Leu Asp Thr Asn Cys Cys Gly Phe Arg Pro Arg Lys Glu 
385                 390                 395                 400 


Asp Ala Cys Val Gln Asn Gly Leu Arg Pro Lys Cys Asp Asp Gln Gly 
                405                 410                 415     


Ser Ala Ala Leu Ala His Ile Ile Gln Arg Lys His Asp Pro Arg His 
            420                 425                 430         


Leu Val Phe Ile Asp Asn Lys Gly Phe Phe Asp Arg Ser Glu Asp Asn 
        435                 440                 445             


Leu Asn Phe Lys Leu Leu Glu Gly Ile Lys Glu Phe Pro Ala Ser Ala 
    450                 455                 460                 


Val Ser Val Leu Lys Ser Gln His Leu Arg Gln Lys Leu Leu Gln Ser 
465                 470                 475                 480 


Leu Phe Leu Asp Lys Val Tyr Trp Glu Ser Gln Gly Gly Arg Gln Gly 
                485                 490                 495     


Ile Glu Lys Leu Ile Asp Val Ile Glu His Arg Ala Lys Ile Leu Ile 
            500                 505                 510         


Thr Tyr Ile Asn Ala His Gly Val Lys Val Leu Pro Met Asn Glu 
        515                 520                 525         


<210>  725
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  725

Met Pro Phe Asp Phe Arg Arg Phe Asp Ile Tyr Arg Lys Val Pro Lys 
1               5                   10                  15      


Asp Leu Thr Gln Pro Thr Tyr Thr Gly Ala Ile Ile Ser Ile Cys Cys 
            20                  25                  30          


Cys Leu Phe Ile Leu Phe Leu Phe Leu Ser Glu Leu Thr Gly Phe Ile 
        35                  40                  45              


Thr Thr Glu Val Val Asn Glu Leu Tyr Val Asp Asp Pro Asp Lys Asp 
    50                  55                  60                  


Ser Gly Gly Lys Ile Asp Val Ser Leu Asn Ile Ser Leu Pro Asn Leu 
65                  70                  75                  80  


His Cys Glu Leu Val Gly Leu Asp Ile Gln Asp Glu Met Gly Arg His 
                85                  90                  95      


Glu Val Gly His Ile Asp Asn Ser Met Lys Ile Pro Leu Asn Asn Gly 
            100                 105                 110         


Ala Gly Cys Arg Phe Glu Gly Gln Phe Ser Ile Asn Lys Val Pro Gly 
        115                 120                 125             


Asn Phe His Val Ser Thr His Ser Ala Thr Ala Gln Pro Gln Asn Pro 
    130                 135                 140                 


Asp Met Thr His Val Ile His Lys Leu Ser Phe Gly Asp Thr Leu Gln 
145                 150                 155                 160 


Val Gln Asn Ile His Gly Ala Phe Asn Ala Leu Gly Gly Ala Asp Arg 
                165                 170                 175     


Leu Thr Ser Asn Pro Leu Ala Ser His Asp Tyr Ile Leu Lys Ile Val 
            180                 185                 190         


Pro Thr Val Tyr Glu Asp Lys Ser Gly Lys Gln Arg Tyr Ser Tyr Gln 
        195                 200                 205             


Tyr Thr Val Ala Asn Lys Glu Tyr Val Ala Tyr Ser His Thr Gly Arg 
    210                 215                 220                 


Ile Ile Pro Ala Ile Trp Phe Arg Tyr Asp Leu Ser Pro Ile Thr Val 
225                 230                 235                 240 


Lys Tyr Thr Glu Arg Arg Gln Pro Leu Tyr Arg Phe Ile Thr Thr Ile 
                245                 250                 255     


Cys Ala Ile Ile Gly Gly Thr Phe Thr Val Ala Gly Ile Leu Asp Ser 
            260                 265                 270         


Cys Ile Phe Thr Ala Ser Glu Ala Trp Lys Lys Ile Gln Leu Gly Lys 
        275                 280                 285             


Met His 
    290 


<210>  726
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  726

Met Asp Cys Gly Ser Val Gly Gly Gln Arg Thr Gln Arg Leu Pro Gly 
1               5                   10                  15      


Arg Gln Arg Leu Leu Phe Leu Pro Val Gly Leu Ser Gly Arg Pro Gly 
            20                  25                  30          


Gly Ser Glu Thr Ser Ala Arg Arg Cys Leu Ser Ala Leu Ser Asp Gly 
        35                  40                  45              


Leu Gly Ala Leu Arg Pro Arg Ala Pro Ala Ala Arg Gly Gly Val Ser 
    50                  55                  60                  


Arg Ala Ser Pro Leu Leu Leu Leu Leu Leu Val Pro Ser Pro Arg Leu 
65                  70                  75                  80  


Ala Ala Ala Ala Pro Arg Arg Gln Leu Gly Asp Trp Glu Arg Ser Arg 
                85                  90                  95      


Leu Gly Tyr Ala Ala Pro Pro Ala Gly Arg Ser Ser Ala Trp Arg Cys 
            100                 105                 110         


Ser Pro Gly Val Ala Ala Ala Ala Gly Ala Leu Pro Gln Tyr His Gly 
        115                 120                 125             


Pro Ala Pro Ala Leu Val Ser Cys Arg Arg Glu Leu Ser Leu Ser Ala 
    130                 135                 140                 


Gly Ser Leu Gln Leu Glu Arg Lys Arg Arg Asp Phe Thr Ser Ser Gly 
145                 150                 155                 160 


Ser Arg Lys Leu Tyr Phe Asp Thr His Ala Leu Val Cys Leu Leu Glu 
                165                 170                 175     


Asp Asn Gly Phe Ala Thr Gln Gln Ala Glu Ile Ile Val Ser Ala Leu 
            180                 185                 190         


Val Lys Ile Leu Glu Ala Asn Met Asp Ile Val Tyr Lys Asp Met Val 
        195                 200                 205             


Thr Lys Met Gln Gln Glu Ile Thr Phe Gln Gln Val Met Ser Gln Ile 
    210                 215                 220                 


Ala Asn Val Lys Lys Asp Met Ile Ile Leu Glu Lys Ser Glu Phe Ser 
225                 230                 235                 240 


Ala Leu Arg Ala Glu Asn Glu Lys Ile Lys Leu Glu Leu His Gln Leu 
                245                 250                 255     


Lys Gln Gln Val Met Asp Glu Val Ile Lys Val Arg Thr Asp Thr Lys 
            260                 265                 270         


Leu Asp Phe Asn Leu Glu Lys Ser Arg Val Lys Glu Leu Tyr Ser Leu 
        275                 280                 285             


Asn Glu Lys Lys Leu Leu Glu Leu Arg Thr Glu Ile Val Ala Leu His 
    290                 295                 300                 


Ala Gln Gln Asp Arg Ala Leu Thr Gln Thr Asp Arg Lys Ile Glu Thr 
305                 310                 315                 320 


Glu Val Ala Gly Leu Lys Thr Met Leu Glu Ser His Lys Leu Asp Asn 
                325                 330                 335     


Ile Lys Tyr Leu Ala Gly Ser Ile Phe Thr Cys Leu Thr Val Ala Leu 
            340                 345                 350         


Gly Phe Tyr Arg Leu Trp Ile 
        355                 


<210>  727
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  727

Met Ala Pro Trp Pro Pro Lys Gly Leu Val Pro Ala Val Leu Trp Gly 
1               5                   10                  15      


Leu Ser Leu Phe Leu Asn Leu Pro Gly Pro Ile Trp Leu Gln Pro Ser 
            20                  25                  30          


Pro Pro Pro Gln Ser Ser Pro Pro Pro Gln Pro His Pro Cys His Thr 
        35                  40                  45              


Cys Arg Gly Leu Val Asp Ser Phe Asn Lys Gly Leu Glu Arg Thr Ile 
    50                  55                  60                  


Arg Asp Asn Phe Gly Gly Gly Asn Thr Ala Trp Glu Glu Glu Asn Leu 
65                  70                  75                  80  


Ser Lys Tyr Lys Asp Ser Glu Thr Arg Leu Val Glu Val Leu Glu Gly 
                85                  90                  95      


Val Cys Ser Lys Ser Asp Phe Glu Cys His Arg Leu Leu Glu Leu Ser 
            100                 105                 110         


Glu Glu Leu Val Glu Ser Trp Trp Phe His Lys Gln Gln Glu Ala Pro 
        115                 120                 125             


Asp Leu Phe Gln Trp Leu Cys Ser Asp Ser Leu Lys Leu Cys Cys Pro 
    130                 135                 140                 


Ala Gly Thr Phe Gly Pro Ser Cys Leu Pro Cys Pro Gly Gly Thr Glu 
145                 150                 155                 160 


Arg Pro Cys Gly Gly Tyr Gly Gln Cys Glu Gly Glu Gly Thr Arg Gly 
                165                 170                 175     


Gly Ser Gly His Cys Asp Cys Gln Ala Gly Tyr Gly Gly Glu Ala Cys 
            180                 185                 190         


Gly Gln Cys Gly Leu Gly Tyr Phe Glu Ala Glu Arg Asn Ala Ser His 
        195                 200                 205             


Leu Val Cys Ser Ala Cys Phe Gly Pro Cys Ala Arg Cys Ser Gly Pro 
    210                 215                 220                 


Glu Glu Ser Asn Cys Leu Gln Cys Lys Lys Gly Trp Ala Leu His His 
225                 230                 235                 240 


Leu Lys Cys Val Asp Ile Asp Glu Cys Gly Thr Glu Gly Ala Asn Cys 
                245                 250                 255     


Gly Ala Asp Gln Phe Cys Val Asn Thr Glu Gly Ser Tyr Glu Cys Arg 
            260                 265                 270         


Asp Cys Ala Lys Ala Cys Leu Gly Cys Met Gly Ala Gly Pro Gly Arg 
        275                 280                 285             


Cys Lys Lys Cys Ser Pro Gly Tyr Gln Gln Val Gly Ser Lys Cys Leu 
    290                 295                 300                 


Asp Val Asp Glu Cys Glu Thr Glu Val Cys Pro Gly Glu Asn Lys Gln 
305                 310                 315                 320 


Cys Glu Asn Thr Glu Gly Gly Tyr Arg Cys Ile Cys Ala Glu Gly Tyr 
                325                 330                 335     


Lys Gln Met Glu Gly Ile Cys Val Lys Glu Gln Ile Pro Gly Ala Phe 
            340                 345                 350         


Pro Ile Leu Thr Asp Leu Thr Pro Glu Thr Thr Arg Arg Trp Lys Leu 
        355                 360                 365             


Gly Ser His Pro His Ser Thr Tyr Val Lys Met Lys Met Gln Arg Asp 
    370                 375                 380                 


Glu Ala Thr Phe Pro Gly Leu Tyr Gly Lys Gln Val Ala Lys Leu Gly 
385                 390                 395                 400 


Ser Gln Ser Arg Gln Ser Asp Arg Gly Thr Arg Leu Ile His Ser Gln 
                405                 410                 415     


Gln Ala Ser Ser Gln Arg 
            420         


<210>  728
<211>  619
<212>  PRT
<213>  Homo sapiens

<400>  728

Met Phe Val Pro Arg Ser Leu Lys Ile Lys Arg Asn Ala Asn Asp Asp 
1               5                   10                  15      


Gly Lys Ser Cys Val Ala Lys Ile Ile Lys Pro Asp Pro Glu Asp Leu 
            20                  25                  30          


Gln Leu Asp Lys Ser Arg Asp Val Pro Val Asp Ala Val Ala Thr Glu 
        35                  40                  45              


Ala Ala Thr Ile Asp Arg His Ile Ser Glu Ser Cys Pro Phe Pro Ser 
    50                  55                  60                  


Pro Gly Gly Gln Leu Ala Glu Val His Ser Val Ser Pro Glu Gln Gly 
65                  70                  75                  80  


Ala Lys Asp Ser His Pro Ser Glu Glu Pro Val Lys Ser Phe Ser Lys 
                85                  90                  95      


Thr Gln Arg Trp Ala Glu Pro Gly Glu Pro Ile Cys Val Val Cys Gly 
            100                 105                 110         


Arg Tyr Gly Glu Tyr Ile Cys Asp Lys Thr Asp Glu Asp Val Cys Ser 
        115                 120                 125             


Leu Glu Cys Lys Ala Lys His Leu Leu Gln Val Lys Glu Lys Glu Glu 
    130                 135                 140                 


Lys Ser Lys Leu Ser Asn Pro Gln Lys Ala Asp Ser Glu Pro Glu Ser 
145                 150                 155                 160 


Pro Leu Asn Ala Ser Tyr Val Tyr Lys Glu His Pro Phe Ile Leu Asn 
                165                 170                 175     


Leu Gln Glu Asp Gln Ile Glu Asn Leu Lys Gln Gln Leu Gly Ile Leu 
            180                 185                 190         


Val Gln Gly Gln Glu Val Thr Arg Pro Ile Ile Asp Phe Glu His Cys 
        195                 200                 205             


Ser Leu Pro Glu Val Leu Asn His Asn Leu Lys Lys Ser Gly Tyr Glu 
    210                 215                 220                 


Val Pro Thr Pro Ile Gln Met Gln Met Ile Pro Val Gly Leu Leu Gly 
225                 230                 235                 240 


Arg Asp Ile Leu Ala Ser Ala Asp Thr Gly Ser Gly Lys Thr Ala Ala 
                245                 250                 255     


Phe Leu Leu Pro Val Ile Met Arg Ala Leu Phe Glu Ser Lys Thr Pro 
            260                 265                 270         


Ser Ala Leu Ile Leu Thr Pro Thr Arg Glu Leu Ala Ile Gln Ile Glu 
        275                 280                 285             


Arg Gln Ala Lys Glu Leu Met Ser Gly Leu Pro Arg Met Lys Thr Val 
    290                 295                 300                 


Leu Leu Val Gly Gly Leu Pro Leu Pro Pro Gln Leu Tyr Arg Leu Gln 
305                 310                 315                 320 


Gln His Val Lys Val Ile Ile Ala Thr Pro Gly Arg Leu Leu Asp Ile 
                325                 330                 335     


Ile Lys Gln Ser Ser Val Glu Leu Cys Gly Val Lys Ile Val Val Val 
            340                 345                 350         


Asp Glu Ala Asp Thr Met Leu Lys Met Gly Phe Gln Gln Gln Val Leu 
        355                 360                 365             


Asp Ile Leu Glu Asn Ile Pro Asn Asp Cys Gln Thr Ile Leu Val Ser 
    370                 375                 380                 


Ala Thr Ile Pro Thr Ser Ile Glu Gln Leu Ala Ser Gln Leu Leu His 
385                 390                 395                 400 


Asn Pro Val Arg Ile Ile Thr Gly Glu Lys Asn Leu Pro Cys Ala Asn 
                405                 410                 415     


Val Arg Gln Ile Ile Leu Trp Val Glu Asp Pro Ala Lys Lys Lys Lys 
            420                 425                 430         


Leu Phe Glu Ile Leu Asn Asp Lys Lys Leu Phe Lys Pro Pro Val Leu 
        435                 440                 445             


Val Phe Val Asp Cys Lys Leu Gly Ala Asp Leu Leu Ser Glu Ala Val 
    450                 455                 460                 


Gln Lys Ile Thr Gly Leu Lys Ser Ile Ser Ile His Ser Glu Lys Ser 
465                 470                 475                 480 


Gln Ile Glu Arg Lys Asn Ile Leu Lys Gly Leu Leu Glu Gly Asp Tyr 
                485                 490                 495     


Glu Val Val Val Ser Thr Gly Val Leu Gly Arg Gly Leu Asp Leu Ile 
            500                 505                 510         


Ser Val Arg Leu Val Val Asn Phe Asp Met Pro Ser Ser Met Asp Glu 
        515                 520                 525             


Tyr Val His Gln Ile Gly Arg Val Gly Arg Leu Gly Gln Asn Gly Thr 
    530                 535                 540                 


Ala Ile Thr Phe Ile Asn Asn Asn Ser Lys Arg Leu Phe Trp Asp Ile 
545                 550                 555                 560 


Ala Lys Arg Val Lys Pro Thr Gly Ser Ile Leu Pro Pro Gln Leu Leu 
                565                 570                 575     


Asn Ser Pro Tyr Leu His Asp Gln Lys Arg Lys Glu Gln Gln Lys Asp 
            580                 585                 590         


Lys Gln Thr Gln Asn Asp Leu Val Thr Gly Ala Asn Leu Met Asp Ile 
        595                 600                 605             


Ile Arg Lys His Asp Lys Ser Asn Ser Gln Lys 
    610                 615                 


<210>  729
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  729

Met Glu Arg Leu Lys Ser His Lys Pro Ala Thr Met Thr Ile Met Val 
1               5                   10                  15      


Glu Asp Ile Met Lys Leu Leu Cys Ser Leu Ser Gly Glu Arg Lys Met 
            20                  25                  30          


Lys Ala Ala Val Lys His Ser Gly Lys Gly Ala Leu Val Thr Gly Ala 
        35                  40                  45              


Met Ala Phe Val Gly Gly Leu Val Gly Gly Pro Pro Gly Leu Ala Val 
    50                  55                  60                  


Gly Gly Ala Val Gly Gly Leu Leu Gly Ala Trp Met Thr Ser Gly Gln 
65                  70                  75                  80  


Phe Lys Pro Val Pro Gln Ile Leu Met Glu Leu Pro Pro Ala Glu Gln 
                85                  90                  95      


Gln Arg Leu Phe Asn Glu Ala Ala Ala Ile Ile Arg His Leu Glu Trp 
            100                 105                 110         


Thr Asp Ala Val Gln Leu Thr Ala Leu Val Met Gly Ser Glu Ala Leu 
        115                 120                 125             


Gln Gln Gln Leu Leu Ala Met Leu Val Asn Tyr Val Thr Lys Glu Leu 
    130                 135                 140                 


Arg Ala Glu Ile Gln Tyr Asp Asp 
145                 150         


<210>  730
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  730

Met Glu Gly Asp Cys Leu Ser Cys Met Lys Tyr Leu Met Phe Val Phe 
1               5                   10                  15      


Asn Phe Phe Ile Phe Leu Gly Gly Ala Cys Leu Leu Ala Ile Gly Ile 
            20                  25                  30          


Trp Val Met Val Asp Pro Thr Gly Phe Arg Glu Ile Val Ala Ala Asn 
        35                  40                  45              


Pro Leu Leu Leu Thr Gly Ala Tyr Ile Leu Leu Ala Met Gly Gly Leu 
    50                  55                  60                  


Leu Phe Leu Leu Gly Phe Leu Gly Cys Cys Gly Ala Val Arg Glu Asn 
65                  70                  75                  80  


Lys Cys Leu Leu Leu Phe Phe Phe Leu Phe Ile Leu Ile Ile Phe Leu 
                85                  90                  95      


Ala Glu Leu Ser Ala Ala Ile Leu Ala Phe Ile Phe Arg Glu Asn Leu 
            100                 105                 110         


Thr Arg Glu Phe Phe Thr Lys Glu Leu Thr Lys His Tyr Gln Gly Asn 
        115                 120                 125             


Asn Asp Thr Asp Val Phe Ser Ala Thr Trp Asn Ser Val Met Ile Thr 
    130                 135                 140                 


Phe Gly Cys Cys Gly Val Asn Gly Pro Glu Asp Phe Lys Phe Ala Ser 
145                 150                 155                 160 


Val Phe Arg Leu Leu Thr Leu Asp Ser Glu Glu Val Pro Glu Ala Cys 
                165                 170                 175     


Cys Arg Arg Glu Pro Gln Ser Arg Asp Gly Val Leu Leu Ser Arg Glu 
            180                 185                 190         


Glu Cys Leu Leu Gly Arg Ser Leu Phe Leu Asn Lys Gln Gly Cys Tyr 
        195                 200                 205             


Thr Val Ile Leu Asn Thr Phe Glu Thr Tyr Val Tyr Leu Ala Gly Ala 
    210                 215                 220                 


Leu Ala Ile Gly Val Leu Ala Ile Glu Leu Phe Ala Met Ile Phe Ala 
225                 230                 235                 240 


Met Cys Leu Phe Arg Gly Ile Gln 
                245             


<210>  731
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  731

Met Thr Ala Trp Ile Leu Leu Pro Val Ser Leu Ser Ala Phe Ser Ile 
1               5                   10                  15      


Thr Gly Ile Trp Thr Val Tyr Ala Met Ala Val Met Asn His His Val 
            20                  25                  30          


Cys Pro Val Glu Asn Trp Ser Tyr Asn Glu Ser Cys Pro Pro Asp Pro 
        35                  40                  45              


Ala Glu Gln Gly Gly Pro Lys Thr Cys Cys Thr Leu Asp Asp Val Pro 
    50                  55                  60                  


Leu Ile Ser Lys Cys Gly Ser Tyr Pro Pro Glu Ser Cys Leu Phe Ser 
65                  70                  75                  80  


Leu Ile Gly Asn Met Gly Ala Phe Met Val Ala Leu Ile Cys Leu Leu 
                85                  90                  95      


Arg Tyr Gly Gln Leu Leu Glu Gln Ser Arg His Ser Trp Val Asn Thr 
            100                 105                 110         


Thr Ala Leu Ile Thr Gly Cys Thr Asn Ala Ala Gly Leu Leu Val Val 
        115                 120                 125             


Gly Asn Phe Gln Val Asp His Ala Arg Ser Leu His Tyr Val Gly Ala 
    130                 135                 140                 


Gly Val Ala Phe Pro Ala Gly Leu Leu Phe Val Cys Leu His Cys Ala 
145                 150                 155                 160 


Leu Ser Tyr Gln Gly Ala Thr Ala Pro Leu Asp Leu Ala Val Ala Tyr 
                165                 170                 175     


Leu Arg Ser Val Leu Ala Val Ile Ala Phe Ile Thr Leu Val Leu Ser 
            180                 185                 190         


Gly Val Phe Phe Val His Glu Ser Ser Gln Leu Gln His Gly Ala Ala 
        195                 200                 205             


Leu Cys Glu Trp Val Cys Val Ile Asp Ile Leu Ile Phe Tyr Gly Thr 
    210                 215                 220                 


Phe Ser Tyr Glu Phe Gly Ala Val Ser Ser Asp Thr Leu Val Ala Ala 
225                 230                 235                 240 


Leu Gln Pro Thr Pro Gly Arg Ala Cys Lys Ser Ser Gly Ser Ser Ser 
                245                 250                 255     


Thr Ser Thr His Leu Asn Cys Ala Pro Glu Ser Ile Ala Met Ile 
            260                 265                 270     


<210>  732
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  732

Met Ala Arg Arg Arg Arg Arg Ala Cys Ile Ala Leu Phe Leu Val Leu 
1               5                   10                  15      


Leu Phe Ala Phe Gly Thr Leu Met Gly Leu Arg Thr Leu Lys Ala Pro 
            20                  25                  30          


Asp Gly Leu Pro Ala Leu Gly Pro Gly Leu Glu Leu Ala Pro Phe Glu 
        35                  40                  45              


Arg Arg Pro Glu Gly Ala Pro Ala Pro Ala Ala Arg Ala Pro Ala Ala 
    50                  55                  60                  


Pro Ala Ala Pro Pro Pro Pro Pro Pro Pro Pro Arg Thr Ala Asp Pro 
65                  70                  75                  80  


Gly Gly Ser Pro Gly Pro Ala Pro Ala Glu Ala Glu Pro Ala Pro Val 
                85                  90                  95      


Gln Ser Leu Arg Val Tyr Ser Asp Leu His Ala Phe Tyr Tyr Ser Trp 
            100                 105                 110         


Tyr Gly Ser Pro Arg Arg Glu Gly His Tyr Ile His Trp Asp His Val 
        115                 120                 125             


Met Val Pro His Trp Asp Pro Lys Ile Ser Ala Ser Tyr Pro Arg Gly 
    130                 135                 140                 


Arg His Ser Pro Pro Asp Asp Leu Gly Ser Ser Phe Tyr Pro Glu Leu 
145                 150                 155                 160 


Gly Pro Tyr Ser Ser Arg Asp Pro Glu Val Leu Arg Glu His Met Thr 
                165                 170                 175     


Gln Leu Lys Glu Ala Ala Ile Gly Val Leu Val Leu Ser Trp Tyr Pro 
            180                 185                 190         


Pro Gly Met Ala Asp Asp Asn Gly Glu Pro Ser Asp Asp Leu Val Pro 
        195                 200                 205             


Ala Ile Leu Asp Thr Ala His Gln Tyr Ser Ile Gln Val Ala Phe His 
    210                 215                 220                 


Ile Gln Pro Tyr Lys Gly Arg Asp Asp Ile Thr Val His Asp Asn Ile 
225                 230                 235                 240 


Lys Tyr Ile Ile Asp Thr Thr Gly Lys Leu 
                245                 250 


<210>  733
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  733

Met Arg Leu Leu Ala Leu Ala Ala Ala Ala Leu Leu Ala Arg Ala Pro 
1               5                   10                  15      


Ala Pro Glu Val Cys Ala Ala Leu Asn Val Thr Val Ser Pro Gly Pro 
            20                  25                  30          


Val Val Asp Tyr Leu Glu Gly Glu Asn Ala Thr Leu Leu Cys His Val 
        35                  40                  45              


Ser Gln Lys Arg Arg Lys Asp Ser Leu Leu Ala Val Arg Trp Phe Phe 
    50                  55                  60                  


Ala His Ser Phe Asp Ser Gln Glu Ala Leu Met Val Lys Met Thr Lys 
65                  70                  75                  80  


Leu Arg Val Val Gln Tyr Tyr Gly Asn Phe Ser Arg Ser Ala Lys Arg 
                85                  90                  95      


Arg Arg Leu Arg Leu Leu Glu Glu Gln Arg Gly Ala Leu Tyr Arg Leu 
            100                 105                 110         


Ser Val Leu Thr Leu Gln Pro Ser Asp Gln Gly His Tyr Val Cys Arg 
        115                 120                 125             


Val Gln Glu Ile Ser Arg His Arg Asn Lys Trp Thr Ala Trp Ser Asn 
    130                 135                 140                 


Gly Ser Ser Ala Thr Glu Met Arg Val Ile Ser Leu Lys Ala Ser Glu 
145                 150                 155                 160 


Glu Ser Ser Phe Glu Lys Thr Lys Glu Thr Trp Ala Phe Phe Glu Asp 
                165                 170                 175     


Leu Tyr Val Tyr Ala Val Leu Val Cys Cys Val Gly Ile Leu Ser Ile 
            180                 185                 190         


Leu Leu Phe Met Leu Val Ile Val Trp Gln Ser Val Phe Asn Lys Arg 
        195                 200                 205             


Lys Ser Arg Val Arg His Tyr Leu Val Lys Cys Pro Gln Asn Ser Ser 
    210                 215                 220                 


Gly Glu Thr Val Thr Ser Val Thr Ser Leu Ala Pro Leu Gln Pro Lys 
225                 230                 235                 240 


Lys Gly Lys Arg Gln Lys Glu Lys Pro Asp Ile Pro Pro Ala Val Pro 
                245                 250                 255     


Ala Lys Ala Pro Ile Ala Pro Thr Phe His Lys Pro Lys Leu Leu Lys 
            260                 265                 270         


Pro Gln Arg Lys Val Thr Leu Pro Lys Ile Ala Glu Glu Asn Leu Thr 
        275                 280                 285             


Tyr Ala Glu Leu Glu Leu Ile Lys Pro His Arg Ala Ala Lys Gly Ala 
    290                 295                 300                 


Pro Thr Ser Thr Val Tyr Ala Gln Ile Leu Phe Glu Glu Asn Lys Leu 
305                 310                 315                 320 


<210>  734
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  734

Met Glu Leu Glu Val Arg Arg Val Arg Gln Ala Phe Leu Ser Gly Arg 
1               5                   10                  15      


Ser Arg Pro Leu Arg Phe Arg Leu Gln Gln Leu Glu Ala Leu Arg Arg 
            20                  25                  30          


Met Val Gln Glu Arg Glu Lys Asp Ile Leu Thr Ala Ile Ala Ala Asp 
        35                  40                  45              


Leu Cys Lys Ser Glu Phe Asn Val Tyr Ser Gln Glu Val Ile Thr Val 
    50                  55                  60                  


Leu Gly Glu Ile Asp Phe Met Leu Glu Asn Leu Pro Glu Trp Val Thr 
65                  70                  75                  80  


Ala Lys Pro Val Lys Lys Asn Val Leu Thr Met Leu Asp Glu Ala Tyr 
                85                  90                  95      


Ile Gln Pro Gln Pro Leu Gly Val Val Leu Ile Ile Gly Ala Trp Asn 
            100                 105                 110         


Tyr Pro Phe Val Leu Thr Ile Gln Pro Leu Ile Gly Ala Ile Ala Ala 
        115                 120                 125             


Gly Asn Ala Val Ile Ile Lys Pro Ser Glu Leu Ser Glu Asn Thr Ala 
    130                 135                 140                 


Lys Ile Leu Ala Lys Leu Leu Pro Gln Tyr Leu Asp Gln Asp Leu Tyr 
145                 150                 155                 160 


Ile Val Ile Asn Gly Gly Val Glu Glu Thr Thr Glu Leu Leu Lys Gln 
                165                 170                 175     


Arg Phe Asp His Ile Phe Tyr Thr Gly Asn Thr Ala Val Gly Lys Ile 
            180                 185                 190         


Val Met Glu Ala Ala Ala Lys His Leu Thr Pro Val Thr Leu Glu Leu 
        195                 200                 205             


Gly Gly Lys Ser Pro Cys Tyr Ile Asp Lys Asp Cys Asp Leu Asp Ile 
    210                 215                 220                 


Val Cys Arg Arg Ile Thr Trp Gly Lys Tyr Met Asn Cys Gly Gln Thr 
225                 230                 235                 240 


Cys Ile Ala Pro Asp Tyr Ile Leu Cys Glu Ala Ser Leu Gln Asn Gln 
                245                 250                 255     


Ile Val Trp Lys Ile Lys Glu Thr Val Lys Glu Phe Tyr Gly Glu Asn 
            260                 265                 270         


Ile Lys Glu Ser Pro Asp Tyr Glu Arg Ile Ile Asn Leu Arg His Phe 
        275                 280                 285             


Lys Arg Ile Leu Ser Leu Leu Glu Gly Gln Lys Ile Ala Phe Gly Gly 
    290                 295                 300                 


Glu Thr Asp Glu Ala Thr Arg Tyr Ile Ala Pro Thr Val Leu Thr Asp 
305                 310                 315                 320 


Val Asp Pro Lys Thr Lys Val Met Gln Glu Glu Ile Phe Gly Pro Ile 
                325                 330                 335     


Leu Pro Ile Val Pro Val Lys Asn Val Asp Glu Ala Ile Asn Phe Ile 
            340                 345                 350         


Asn Glu Arg Glu Lys Pro Leu Ala Leu Tyr Val Phe Ser His Asn His 
        355                 360                 365             


Lys Leu Ile Lys Arg Met Ile Asp Glu Thr Ser Ser Gly Gly Val Thr 
    370                 375                 380                 


Gly Asn Asp Val Ile Met His Phe Thr Leu Asn Ser Phe Pro Phe Gly 
385                 390                 395                 400 


Gly Val Gly Ser Ser Gly Met Gly Ala Tyr His Gly Lys His Ser Phe 
                405                 410                 415     


Asp Thr Phe Ser His Gln Arg Pro Cys Leu Leu Lys Ser Leu Lys Arg 
            420                 425                 430         


Glu Gly Ala Asn Lys Leu Arg Tyr Pro Pro Asn Ser Gln Ser Lys Val 
        435                 440                 445             


Asp Trp Gly Lys Phe Phe Leu Leu Lys Arg Phe Asn Lys Glu Lys Leu 
    450                 455                 460                 


Gly Leu Leu Leu Leu Thr Phe Leu Gly Ile Val Ala Ala Val Leu Val 
465                 470                 475                 480 


Lys Lys Tyr Gln Ala Val Leu Arg Arg Lys Ala Leu Leu Ile Phe Leu 
                485                 490                 495     


Val Val His Arg Leu Arg Trp Ser Ser Lys Gln Arg 
            500                 505             


<210>  735
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  735

Met Ala Ser His Glu Val Asp Asn Ala Glu Leu Gly Ser Ala Ser Ala 
1               5                   10                  15      


His Gly Thr Pro Gly Ser Glu Ala Gly Pro Glu Glu Leu Asn Thr Ser 
            20                  25                  30          


Val Tyr Gln Pro Ile Asp Gly Ser Pro Asp Tyr Gln Lys Ala Lys Leu 
        35                  40                  45              


Gln Val Leu Gly Phe Cys Ser Ser Gly Thr Leu Ser Val Val Ala Gly 
    50                  55                  60                  


Ile Lys Pro Thr Arg Thr Trp Ile Gln Asn Ser Phe Gly Met Asn Ile 
65                  70                  75                  80  


Ala Ser Ala Thr Ile Ala Leu Val Gly Thr Ala Phe Leu Ser Leu Asn 
                85                  90                  95      


Ile Ala Val Asn Ile Gln Ser Leu Arg Ser Cys His Ser Ser Ser Glu 
            100                 105                 110         


Ser Pro Asp Leu Cys Asn Tyr Met Gly Ser Ile Ser Asn Gly Met Val 
        115                 120                 125             


Ser Leu Leu Leu Ile Leu Thr Leu Leu Glu Leu Cys Val Thr Ile Ser 
    130                 135                 140                 


Thr Ile Ala Met Trp Cys Asn Ala Asn Cys Cys Asn Ser Arg Glu Glu 
145                 150                 155                 160 


Ile Ser Ser Pro Pro Asn Ser Val 
                165             


<210>  736
<211>  4870
<212>  PRT
<213>  Homo sapiens

<400>  736

Met Ala Glu Gly Gly Glu Gly Gly Glu Asp Glu Ile Gln Phe Leu Arg 
1               5                   10                  15      


Thr Glu Asp Glu Val Val Leu Gln Cys Ile Ala Thr Ile His Lys Glu 
            20                  25                  30          


Gln Arg Lys Phe Cys Leu Ala Ala Glu Gly Leu Gly Asn Arg Leu Cys 
        35                  40                  45              


Phe Leu Glu Pro Thr Ser Glu Ala Lys Tyr Ile Pro Pro Asp Leu Cys 
    50                  55                  60                  


Val Cys Asn Phe Val Leu Glu Gln Ser Leu Ser Val Arg Ala Leu Gln 
65                  70                  75                  80  


Glu Met Leu Ala Asn Thr Gly Glu Asn Gly Gly Glu Gly Ala Ala Gln 
                85                  90                  95      


Gly Gly Gly His Arg Thr Leu Leu Tyr Gly His Ala Val Leu Leu Arg 
            100                 105                 110         


His Ser Phe Ser Gly Met Tyr Leu Thr Cys Leu Thr Thr Ser Arg Ser 
        115                 120                 125             


Gln Thr Asp Lys Leu Ala Phe Asp Val Gly Leu Arg Glu His Ala Thr 
    130                 135                 140                 


Gly Glu Ala Cys Trp Trp Thr Ile His Pro Ala Ser Lys Gln Arg Ser 
145                 150                 155                 160 


Glu Gly Glu Lys Val Arg Ile Gly Asp Asp Leu Ile Leu Val Ser Val 
                165                 170                 175     


Ser Ser Glu Arg Tyr Leu His Leu Ser Val Ser Asn Gly Asn Ile Gln 
            180                 185                 190         


Val Asp Ala Ser Phe Met Gln Thr Leu Trp Asn Val His Pro Thr Cys 
        195                 200                 205             


Ser Gly Ser Ser Ile Glu Glu Gly Tyr Leu Leu Gly Gly His Val Val 
    210                 215                 220                 


Arg Leu Phe His Gly His Asp Glu Cys Leu Thr Ile Pro Ser Thr Asp 
225                 230                 235                 240 


Gln Asn Asp Ser Gln His Arg Arg Ile Phe Tyr Glu Ala Gly Gly Ala 
                245                 250                 255     


Gly Thr Arg Ala Arg Ser Leu Trp Arg Val Glu Pro Leu Arg Ile Ser 
            260                 265                 270         


Trp Ser Gly Ser Asn Ile Arg Trp Gly Gln Ala Phe Arg Leu Arg His 
        275                 280                 285             


Leu Thr Thr Gly His Tyr Leu Ala Leu Thr Glu Asp Gln Gly Leu Ile 
    290                 295                 300                 


Leu Gln Asp Arg Ala Lys Ser Asp Thr Lys Ser Thr Ala Phe Ser Phe 
305                 310                 315                 320 


Arg Ala Ser Lys Glu Leu Lys Glu Lys Leu Asp Ser Ser His Lys Arg 
                325                 330                 335     


Asp Ile Glu Gly Met Gly Val Pro Glu Ile Lys Tyr Gly Asp Ser Val 
            340                 345                 350         


Cys Phe Val Gln His Ile Ala Ser Gly Leu Trp Val Thr Tyr Lys Ala 
        355                 360                 365             


Gln Asp Ala Lys Thr Ser Arg Leu Gly Pro Leu Lys Arg Lys Val Ile 
    370                 375                 380                 


Leu His Gln Glu Gly His Met Asp Asp Gly Leu Thr Leu Gln Arg Cys 
385                 390                 395                 400 


Gln Arg Glu Glu Ser Gln Ala Ala Arg Ile Ile Arg Asn Thr Thr Ala 
                405                 410                 415     


Leu Phe Ser Gln Phe Val Ser Gly Asn Asn Arg Thr Ala Ala Pro Ile 
            420                 425                 430         


Thr Leu Pro Ile Glu Glu Val Leu Gln Thr Leu Gln Asp Leu Ile Ala 
        435                 440                 445             


Tyr Phe Gln Pro Pro Glu Glu Glu Met Arg His Glu Asp Lys Gln Asn 
    450                 455                 460                 


Lys Leu Arg Ser Leu Lys Asn Arg Gln Asn Leu Phe Lys Glu Glu Gly 
465                 470                 475                 480 


Met Leu Ala Leu Val Leu Asn Cys Ile Asp Arg Leu Asn Val Tyr Asn 
                485                 490                 495     


Ser Val Ala His Phe Ala Gly Ile Ala Arg Glu Glu Ser Gly Met Ala 
            500                 505                 510         


Trp Lys Glu Ile Leu Asn Leu Leu Tyr Lys Leu Leu Ala Ala Leu Ile 
        515                 520                 525             


Arg Gly Asn Arg Asn Asn Cys Ala Gln Phe Ser Asn Asn Leu Asp Trp 
    530                 535                 540                 


Leu Ile Ser Lys Leu Asp Arg Leu Glu Ser Ser Ser Gly Ile Leu Glu 
545                 550                 555                 560 


Val Leu His Cys Ile Leu Thr Glu Ser Pro Glu Ala Leu Asn Leu Ile 
                565                 570                 575     


Ala Glu Gly His Ile Lys Ser Ile Ile Ser Leu Leu Asp Lys His Gly 
            580                 585                 590         


Arg Asn His Lys Val Leu Asp Ile Leu Cys Ser Leu Cys Leu Cys Asn 
        595                 600                 605             


Gly Val Ala Val Arg Ala Asn Gln Asn Leu Ile Cys Asp Asn Leu Leu 
    610                 615                 620                 


Pro Arg Arg Asn Leu Leu Leu Gln Thr Arg Leu Ile Asn Asp Val Thr 
625                 630                 635                 640 


Ser Ile Arg Pro Asn Ile Phe Leu Gly Val Ala Glu Gly Ser Ala Gln 
                645                 650                 655     


Tyr Lys Lys Trp Tyr Phe Glu Leu Ile Ile Asp Gln Val Asp Pro Phe 
            660                 665                 670         


Leu Thr Ala Glu Pro Thr His Leu Arg Val Gly Trp Ala Ser Ser Ser 
        675                 680                 685             


Gly Tyr Ala Pro Tyr Pro Gly Gly Gly Glu Gly Trp Gly Gly Asn Gly 
    690                 695                 700                 


Val Gly Asp Asp Leu Tyr Ser Tyr Gly Phe Asp Gly Leu His Leu Trp 
705                 710                 715                 720 


Ser Gly Arg Ile Pro Arg Ala Val Ala Ser Ile Asn Gln His Leu Leu 
                725                 730                 735     


Arg Ser Asp Asp Val Val Ser Cys Cys Leu Asp Leu Gly Val Pro Ser 
            740                 745                 750         


Ile Ser Phe Arg Ile Asn Gly Gln Pro Val Gln Gly Met Phe Glu Asn 
        755                 760                 765             


Phe Asn Thr Asp Gly Leu Phe Phe Pro Val Met Ser Phe Ser Ala Gly 
    770                 775                 780                 


Val Lys Val Arg Phe Leu Met Gly Gly Arg His Gly Glu Phe Lys Phe 
785                 790                 795                 800 


Leu Pro Pro Ser Gly Tyr Ala Pro Cys Tyr Glu Ala Leu Leu Pro Lys 
                805                 810                 815     


Glu Lys Met Arg Leu Glu Pro Val Lys Glu Tyr Lys Arg Asp Ala Asp 
            820                 825                 830         


Gly Ile Arg Asp Leu Leu Gly Thr Thr Gln Phe Leu Ser Gln Ala Ser 
        835                 840                 845             


Phe Ile Pro Cys Pro Val Asp Thr Ser Gln Val Ile Leu Pro Pro His 
    850                 855                 860                 


Leu Glu Lys Ile Arg Asp Arg Leu Ala Glu Asn Ile His Glu Leu Trp 
865                 870                 875                 880 


Gly Met Asn Lys Ile Glu Leu Gly Trp Thr Phe Gly Lys Ile Arg Asp 
                885                 890                 895     


Asp Asn Lys Arg Gln His Pro Cys Leu Val Glu Phe Ser Lys Leu Pro 
            900                 905                 910         


Glu Thr Glu Lys Asn Tyr Asn Leu Gln Met Ser Thr Glu Thr Leu Lys 
        915                 920                 925             


Thr Leu Leu Ala Leu Gly Cys His Ile Ala His Val Asn Pro Ala Ala 
    930                 935                 940                 


Glu Glu Asp Leu Lys Lys Val Lys Leu Pro Lys Asn Tyr Met Met Ser 
945                 950                 955                 960 


Asn Gly Tyr Lys Pro Ala Pro Leu Asp Leu Ser Asp Val Lys Leu Leu 
                965                 970                 975     


Pro Pro Gln Glu Ile Leu Val Asp Lys Leu Ala Glu Asn Ala His Asn 
            980                 985                 990         


Val Trp Ala Lys Asp Arg Ile Lys  Gln Gly Trp Thr Tyr  Gly Ile Gln 
        995                 1000                 1005             


Gln Asp  Leu Lys Asn Lys Arg  Asn Pro Arg Leu Val  Pro Tyr Ala 
    1010                 1015                 1020             


Leu Leu  Asp Glu Arg Thr Lys  Lys Ser Asn Arg Asp  Ser Leu Arg 
    1025                 1030                 1035             


Glu Ala  Val Arg Thr Phe Val  Gly Tyr Gly Tyr Asn  Ile Glu Pro 
    1040                 1045                 1050             


Ser Asp  Gln Glu Leu Ala Asp  Ser Ala Val Glu Lys  Val Ser Ile 
    1055                 1060                 1065             


Asp Lys  Ile Arg Phe Phe Arg  Val Glu Arg Ser Tyr  Ala Val Arg 
    1070                 1075                 1080             


Ser Gly  Lys Trp Tyr Phe Glu  Phe Glu Val Val Thr  Gly Gly Asp 
    1085                 1090                 1095             


Met Arg  Val Gly Trp Ala Arg  Pro Gly Cys Arg Pro  Asp Val Glu 
    1100                 1105                 1110             


Leu Gly  Ala Asp Asp Gln Ala  Phe Val Phe Glu Gly  Asn Arg Gly 
    1115                 1120                 1125             


Gln Arg  Trp His Gln Gly Ser  Gly Tyr Phe Gly Arg  Thr Trp Gln 
    1130                 1135                 1140             


Pro Gly  Asp Val Val Gly Cys  Met Ile Asn Leu Asp  Asp Ala Ser 
    1145                 1150                 1155             


Met Ile  Phe Thr Leu Asn Gly  Glu Leu Leu Ile Thr  Asn Lys Gly 
    1160                 1165                 1170             


Ser Glu  Leu Ala Phe Ala Asp  Tyr Glu Ile Glu Asn  Gly Phe Val 
    1175                 1180                 1185             


Pro Ile  Cys Cys Leu Gly Leu  Ser Gln Ile Gly Arg  Met Asn Leu 
    1190                 1195                 1200             


Gly Thr  Asp Ala Ser Thr Phe  Lys Phe Tyr Thr Met  Cys Gly Leu 
    1205                 1210                 1215             


Gln Glu  Gly Phe Glu Pro Phe  Ala Val Asn Met Asn  Arg Asp Val 
    1220                 1225                 1230             


Ala Met  Trp Phe Ser Lys Arg  Leu Pro Thr Phe Val  Asn Val Pro 
    1235                 1240                 1245             


Lys Asp  His Pro His Ile Glu  Val Met Arg Ile Asp  Gly Thr Met 
    1250                 1255                 1260             


Asp Ser  Pro Pro Cys Leu Lys  Val Thr His Lys Thr  Phe Gly Thr 
    1265                 1270                 1275             


Gln Asn  Ser Asn Ala Asp Met  Ile Tyr Cys Arg Leu  Ser Met Pro 
    1280                 1285                 1290             


Val Glu  Cys His Ser Ser Phe  Ser His Ser Pro Cys  Leu Asp Ser 
    1295                 1300                 1305             


Glu Ala  Phe Gln Lys Arg Lys  Gln Met Gln Glu Ile  Leu Ser His 
    1310                 1315                 1320             


Thr Thr  Thr Gln Cys Tyr Tyr  Ala Ile Arg Ile Phe  Ala Gly Gln 
    1325                 1330                 1335             


Asp Pro  Ser Cys Val Trp Val  Gly Trp Val Thr Pro  Asp Tyr His 
    1340                 1345                 1350             


Leu Tyr  Ser Glu Lys Phe Asp  Leu Asn Lys Asn Cys  Thr Val Thr 
    1355                 1360                 1365             


Val Thr  Leu Gly Asp Glu Arg  Gly Arg Val His Glu  Ser Val Lys 
    1370                 1375                 1380             


Arg Ser  Asn Cys Tyr Met Val  Trp Gly Gly Asp Ile  Val Ala Ser 
    1385                 1390                 1395             


Ser Gln  Arg Ser Asn Arg Ser  Asn Val Asp Leu Glu  Ile Gly Cys 
    1400                 1405                 1410             


Leu Val  Asp Leu Ala Met Gly  Met Leu Ser Phe Ser  Ala Asn Gly 
    1415                 1420                 1425             


Lys Glu  Leu Gly Thr Cys Tyr  Gln Val Glu Pro Asn  Thr Lys Val 
    1430                 1435                 1440             


Phe Pro  Ala Val Phe Leu Gln  Pro Thr Ser Thr Ser  Leu Phe Gln 
    1445                 1450                 1455             


Phe Glu  Leu Gly Lys Leu Lys  Asn Ala Met Pro Leu  Ser Ala Ala 
    1460                 1465                 1470             


Ile Phe  Arg Ser Glu Glu Lys  Asn Pro Val Pro Gln  Cys Pro Pro 
    1475                 1480                 1485             


Arg Leu  Asp Val Gln Thr Ile  Gln Pro Val Leu Trp  Ser Arg Met 
    1490                 1495                 1500             


Pro Asn  Ser Phe Leu Lys Val  Glu Thr Glu Arg Val  Ser Glu Arg 
    1505                 1510                 1515             


His Gly  Trp Val Val Gln Cys  Leu Glu Pro Leu Gln  Met Met Ala 
    1520                 1525                 1530             


Leu His  Ile Pro Glu Glu Asn  Arg Cys Val Asp Ile  Leu Glu Leu 
    1535                 1540                 1545             


Cys Glu  Gln Glu Asp Leu Met  Arg Phe His Tyr His  Thr Leu Arg 
    1550                 1555                 1560             


Leu Tyr  Ser Ala Val Cys Ala  Leu Gly Asn Ser Arg  Val Ala Tyr 
    1565                 1570                 1575             


Ala Leu  Cys Ser His Val Asp  Leu Ser Gln Leu Phe  Tyr Ala Ile 
    1580                 1585                 1590             


Asp Asn  Lys Tyr Leu Pro Gly  Leu Leu Arg Ser Gly  Phe Tyr Asp 
    1595                 1600                 1605             


Leu Leu  Ile Ser Ile His Leu  Ala Ser Ala Lys Glu  Arg Lys Leu 
    1610                 1615                 1620             


Met Met  Lys Asn Glu Tyr Ile  Ile Pro Ile Thr Ser  Thr Thr Arg 
    1625                 1630                 1635             


Asn Ile  Arg Leu Phe Pro Asp  Glu Ser Lys Arg His  Gly Leu Pro 
    1640                 1645                 1650             


Gly Val  Gly Leu Arg Thr Cys  Leu Lys Pro Gly Phe  Arg Phe Ser 
    1655                 1660                 1665             


Thr Pro  Cys Phe Val Val Thr  Gly Glu Asp His Gln  Lys Gln Ser 
    1670                 1675                 1680             


Pro Glu  Ile Pro Leu Glu Ser  Leu Arg Thr Lys Ala  Leu Ser Met 
    1685                 1690                 1695             


Leu Thr  Glu Ala Val Gln Cys  Ser Gly Ala His Ile  Arg Asp Pro 
    1700                 1705                 1710             


Val Gly  Gly Ser Val Glu Phe  Gln Phe Val Pro Val  Leu Lys Leu 
    1715                 1720                 1725             


Ile Gly  Thr Leu Leu Val Met  Gly Val Phe Asp Asp  Asp Asp Val 
    1730                 1735                 1740             


Arg Gln  Ile Leu Leu Leu Ile  Asp Pro Ser Val Phe  Gly Glu His 
    1745                 1750                 1755             


Ser Ala  Gly Thr Glu Glu Gly  Ala Glu Lys Glu Glu  Val Thr Gln 
    1760                 1765                 1770             


Val Glu  Glu Lys Ala Val Glu  Ala Gly Glu Lys Ala  Gly Lys Glu 
    1775                 1780                 1785             


Ala Pro  Val Lys Gly Leu Leu  Gln Thr Arg Leu Pro  Glu Ser Val 
    1790                 1795                 1800             


Lys Leu  Gln Met Cys Glu Leu  Leu Ser Tyr Leu Cys  Asp Cys Glu 
    1805                 1810                 1815             


Leu Gln  His Arg Val Glu Ala  Ile Val Ala Phe Gly  Asp Ile Tyr 
    1820                 1825                 1830             


Val Ser  Lys Leu Gln Ala Asn  Gln Lys Phe Arg Tyr  Asn Glu Leu 
    1835                 1840                 1845             


Met Gln  Ala Leu Asn Met Ser  Ala Ala Leu Thr Ala  Arg Lys Thr 
    1850                 1855                 1860             


Lys Glu  Phe Arg Ser Pro Pro  Gln Glu Gln Ile Asn  Met Leu Leu 
    1865                 1870                 1875             


Asn Phe  Gln Leu Gly Glu Asn  Cys Pro Cys Pro Glu  Glu Ile Arg 
    1880                 1885                 1890             


Glu Glu  Leu Tyr Asp Phe His  Glu Asp Leu Leu Leu  His Cys Gly 
    1895                 1900                 1905             


Val Pro  Leu Glu Glu Glu Glu  Glu Glu Glu Glu Asp  Thr Ser Trp 
    1910                 1915                 1920             


Thr Gly  Lys Leu Cys Ala Leu  Val Tyr Lys Ile Lys  Gly Pro Pro 
    1925                 1930                 1935             


Lys Pro  Glu Lys Glu Gln Pro  Thr Glu Glu Glu Glu  Arg Cys Pro 
    1940                 1945                 1950             


Thr Thr  Leu Lys Glu Leu Ile  Ser Gln Thr Met Ile  Cys Trp Ala 
    1955                 1960                 1965             


Gln Glu  Asp Gln Ile Gln Asp  Ser Glu Leu Val Arg  Met Met Phe 
    1970                 1975                 1980             


Asn Leu  Leu Arg Arg Gln Tyr  Asp Ser Ile Gly Glu  Leu Leu Gln 
    1985                 1990                 1995             


Ala Leu  Arg Lys Thr Tyr Thr  Ile Ser His Thr Ser  Val Ser Asp 
    2000                 2005                 2010             


Thr Ile  Asn Leu Leu Ala Ala  Leu Gly Gln Ile Arg  Ser Leu Leu 
    2015                 2020                 2025             


Ser Val  Arg Met Gly Lys Glu  Glu Glu Leu Leu Met  Ile Asn Gly 
    2030                 2035                 2040             


Leu Gly  Asp Ile Met Asn Asn  Lys Val Phe Tyr Gln  His Pro Asn 
    2045                 2050                 2055             


Leu Met  Arg Val Leu Gly Met  His Glu Thr Val Met  Glu Val Met 
    2060                 2065                 2070             


Val Asn  Val Leu Gly Thr Glu  Lys Ser Gln Ile Ala  Phe Pro Lys 
    2075                 2080                 2085             


Met Val  Ala Ser Cys Cys Arg  Phe Leu Cys Tyr Phe  Cys Arg Ile 
    2090                 2095                 2100             


Ser Arg  Gln Asn Gln Lys Ala  Met Phe Glu His Leu  Ser Tyr Leu 
    2105                 2110                 2115             


Leu Glu  Asn Ser Ser Val Gly  Leu Ala Ser Pro Ser  Met Arg Gly 
    2120                 2125                 2130             


Ser Thr  Pro Leu Asp Val Ala  Ala Ser Ser Val Met  Asp Asn Asn 
    2135                 2140                 2145             


Glu Leu  Ala Leu Ser Leu Glu  Glu Pro Asp Leu Glu  Lys Val Val 
    2150                 2155                 2160             


Thr Tyr  Leu Ala Gly Cys Gly  Leu Gln Ser Cys Pro  Met Leu Leu 
    2165                 2170                 2175             


Ala Lys  Gly Tyr Pro Asp Val  Gly Trp Asn Pro Ile  Glu Gly Glu 
    2180                 2185                 2190             


Arg Tyr  Leu Ser Phe Leu Arg  Phe Ala Val Phe Val  Asn Ser Glu 
    2195                 2200                 2205             


Ser Val  Glu Glu Asn Ala Ser  Val Val Val Lys Leu  Leu Ile Arg 
    2210                 2215                 2220             


Arg Pro  Glu Cys Phe Gly Pro  Ala Leu Arg Gly Glu  Gly Gly Asn 
    2225                 2230                 2235             


Gly Leu  Leu Ala Ala Met Gln  Gly Ala Ile Lys Ile  Ser Glu Asn 
    2240                 2245                 2250             


Pro Ala  Leu Asp Leu Pro Ser  Gln Gly Tyr Lys Arg  Glu Val Ser 
    2255                 2260                 2265             


Thr Gly  Asp Asp Glu Glu Glu  Glu Glu Ile Val His  Met Gly Asn 
    2270                 2275                 2280             


Ala Ile  Met Ser Phe Tyr Ser  Ala Leu Ile Asp Leu  Leu Gly Arg 
    2285                 2290                 2295             


Cys Ala  Pro Glu Met His Leu  Ile Gln Thr Gly Lys  Gly Glu Ala 
    2300                 2305                 2310             


Ile Arg  Ile Arg Ser Ile Leu  Arg Ser Leu Val Pro  Thr Glu Asp 
    2315                 2320                 2325             


Leu Val  Gly Ile Ile Ser Ile  Pro Leu Lys Leu Pro  Ser Leu Asn 
    2330                 2335                 2340             


Lys Asp  Gly Ser Val Ser Glu  Pro Asp Met Ala Ala  Asn Phe Cys 
    2345                 2350                 2355             


Pro Asp  His Lys Ala Pro Met  Val Leu Phe Leu Asp  Arg Val Tyr 
    2360                 2365                 2370             


Gly Ile  Lys Asp Gln Thr Phe  Leu Leu His Leu Leu  Glu Val Gly 
    2375                 2380                 2385             


Phe Leu  Pro Asp Leu Arg Ala  Ser Ala Ser Leu Asp  Thr Val Ser 
    2390                 2395                 2400             


Leu Ser  Thr Thr Glu Ala Ala  Leu Ala Leu Asn Arg  Tyr Ile Cys 
    2405                 2410                 2415             


Ser Ala  Val Leu Pro Leu Leu  Thr Arg Cys Ala Pro  Leu Phe Ala 
    2420                 2425                 2430             


Gly Thr  Glu His Cys Thr Ser  Leu Ile Asp Ser Thr  Leu Gln Thr 
    2435                 2440                 2445             


Ile Tyr  Arg Leu Ser Lys Gly  Arg Ser Leu Thr Lys  Ala Gln Arg 
    2450                 2455                 2460             


Asp Thr  Ile Glu Glu Cys Leu  Leu Ala Ile Cys Asn  His Leu Arg 
    2465                 2470                 2475             


Pro Ser  Met Leu Gln Gln Leu  Leu Arg Arg Leu Val  Phe Asp Val 
    2480                 2485                 2490             


Pro Gln  Leu Asn Glu Tyr Cys  Lys Met Pro Leu Lys  Leu Leu Thr 
    2495                 2500                 2505             


Asn His  Tyr Glu Gln Cys Trp  Lys Tyr Tyr Cys Leu  Pro Ser Gly 
    2510                 2515                 2520             


Trp Gly  Ser Tyr Gly Leu Ala  Val Glu Glu Glu Leu  His Leu Thr 
    2525                 2530                 2535             


Glu Lys  Leu Phe Trp Gly Ile  Phe Asp Ser Leu Ser  His Lys Lys 
    2540                 2545                 2550             


Tyr Asp  Pro Asp Leu Phe Arg  Met Ala Leu Pro Cys  Leu Ser Ala 
    2555                 2560                 2565             


Ile Ala  Gly Ala Leu Pro Pro  Asp Tyr Leu Asp Thr  Arg Ile Thr 
    2570                 2575                 2580             


Ala Thr  Leu Glu Lys Gln Ile  Ser Val Asp Ala Asp  Gly Asn Phe 
    2585                 2590                 2595             


Asp Pro  Lys Pro Ile Asn Thr  Met Asn Phe Ser Leu  Pro Glu Lys 
    2600                 2605                 2610             


Leu Glu  Tyr Ile Val Thr Lys  Tyr Ala Glu His Ser  His Asp Lys 
    2615                 2620                 2625             


Trp Ala  Cys Asp Lys Ser Gln  Ser Gly Trp Lys Tyr  Gly Ile Ser 
    2630                 2635                 2640             


Leu Asp  Glu Asn Val Lys Thr  His Pro Leu Ile Arg  Pro Phe Lys 
    2645                 2650                 2655             


Thr Leu  Thr Glu Lys Glu Lys  Glu Ile Tyr Arg Trp  Pro Ala Arg 
    2660                 2665                 2670             


Glu Ser  Leu Lys Thr Met Leu  Ala Val Gly Trp Thr  Val Glu Arg 
    2675                 2680                 2685             


Thr Lys  Glu Gly Glu Ala Leu  Val Gln Gln Arg Glu  Asn Glu Lys 
    2690                 2695                 2700             


Leu Arg  Ser Val Ser Gln Ala  Asn Gln Gly Asn Ser  Tyr Ser Pro 
    2705                 2710                 2715             


Ala Pro  Leu Asp Leu Ser Asn  Val Val Leu Ser Arg  Glu Leu Gln 
    2720                 2725                 2730             


Gly Met  Val Glu Val Val Ala  Glu Asn Tyr His Asn  Ile Trp Ala 
    2735                 2740                 2745             


Lys Lys  Lys Lys Leu Glu Leu  Glu Ser Lys Gly Gly  Gly Ser His 
    2750                 2755                 2760             


Pro Leu  Leu Val Pro Tyr Asp  Thr Leu Thr Ala Lys  Glu Lys Phe 
    2765                 2770                 2775             


Lys Asp  Arg Glu Lys Ala Gln  Asp Leu Phe Lys Phe  Leu Gln Val 
    2780                 2785                 2790             


Asn Gly  Ile Ile Val Ser Arg  Gly Met Lys Asp Met  Glu Leu Asp 
    2795                 2800                 2805             


Ala Ser  Ser Met Glu Lys Arg  Phe Ala Tyr Lys Phe  Leu Lys Lys 
    2810                 2815                 2820             


Ile Leu  Lys Tyr Val Asp Ser  Ala Gln Glu Phe Ile  Ala His Leu 
    2825                 2830                 2835             


Glu Ala  Ile Val Ser Ser Gly  Lys Thr Glu Lys Ser  Pro Arg Asp 
    2840                 2845                 2850             


Gln Glu  Ile Lys Phe Phe Ala  Lys Val Leu Leu Pro  Leu Val Asp 
    2855                 2860                 2865             


Gln Tyr  Phe Thr Ser His Cys  Leu Tyr Phe Leu Ser  Ser Pro Leu 
    2870                 2875                 2880             


Lys Pro  Leu Ser Ser Ser Gly  Tyr Ala Ser His Lys  Glu Lys Glu 
    2885                 2890                 2895             


Met Val  Ala Gly Leu Phe Cys  Lys Leu Ala Ala Leu  Val Arg His 
    2900                 2905                 2910             


Arg Ile  Ser Leu Phe Gly Ser  Asp Ser Thr Thr Met  Val Ser Cys 
    2915                 2920                 2925             


Leu His  Ile Leu Ala Gln Thr  Leu Asp Thr Arg Thr  Val Met Lys 
    2930                 2935                 2940             


Ser Gly  Ser Glu Leu Val Lys  Ala Gly Leu Arg Ala  Phe Phe Glu 
    2945                 2950                 2955             


Asn Ala  Ala Glu Asp Leu Glu  Lys Thr Ser Glu Asn  Leu Lys Leu 
    2960                 2965                 2970             


Gly Lys  Phe Thr His Ser Arg  Thr Gln Ile Lys Gly  Val Ser Gln 
    2975                 2980                 2985             


Asn Ile  Asn Tyr Thr Thr Val  Ala Leu Leu Pro Ile  Leu Thr Ser 
    2990                 2995                 3000             


Ile Phe  Glu His Val Thr Gln  His Gln Phe Gly Met  Asp Leu Leu 
    3005                 3010                 3015             


Leu Gly  Asp Val Gln Ile Ser  Cys Tyr His Ile Leu  Cys Ser Leu 
    3020                 3025                 3030             


Tyr Ser  Leu Gly Thr Gly Lys  Asn Ile Tyr Val Glu  Arg Gln Arg 
    3035                 3040                 3045             


Pro Ala  Leu Gly Glu Cys Leu  Ala Ser Leu Ala Ala  Ala Ile Pro 
    3050                 3055                 3060             


Val Ala  Phe Leu Glu Pro Thr  Leu Asn Arg Tyr Asn  Pro Leu Ser 
    3065                 3070                 3075             


Val Phe  Asn Thr Lys Thr Pro  Arg Glu Arg Ser Ile  Leu Gly Met 
    3080                 3085                 3090             


Pro Asp  Thr Val Glu Asp Met  Cys Pro Asp Ile Pro  Gln Leu Glu 
    3095                 3100                 3105             


Gly Leu  Met Lys Glu Ile Asn  Asp Leu Ala Glu Ser  Gly Ala Arg 
    3110                 3115                 3120             


Tyr Thr  Glu Met Pro His Val  Ile Glu Val Ile Leu  Pro Met Leu 
    3125                 3130                 3135             


Cys Asn  Tyr Leu Ser Tyr Trp  Trp Glu Arg Gly Pro  Glu Asn Leu 
    3140                 3145                 3150             


Pro Pro  Ser Thr Gly Pro Cys  Cys Thr Lys Val Thr  Ser Glu His 
    3155                 3160                 3165             


Leu Ser  Leu Ile Leu Gly Asn  Ile Leu Lys Ile Ile  Asn Asn Asn 
    3170                 3175                 3180             


Leu Gly  Ile Asp Glu Ala Ser  Trp Met Lys Arg Ile  Ala Val Tyr 
    3185                 3190                 3195             


Ala Gln  Pro Ile Ile Ser Lys  Ala Arg Pro Asp Leu  Leu Arg Ser 
    3200                 3205                 3210             


His Phe  Ile Pro Thr Leu Glu  Lys Leu Lys Lys Lys  Ala Val Lys 
    3215                 3220                 3225             


Thr Val  Gln Glu Glu Glu Gln  Leu Lys Ala Asp Gly  Lys Gly Asp 
    3230                 3235                 3240             


Thr Gln  Glu Ala Glu Leu Leu  Ile Leu Asp Glu Phe  Ala Val Leu 
    3245                 3250                 3255             


Cys Arg  Asp Leu Tyr Ala Phe  Tyr Pro Met Leu Ile  Arg Tyr Val 
    3260                 3265                 3270             


Asp Asn  Asn Arg Ser Asn Trp  Leu Lys Ser Pro Asp  Ala Asp Ser 
    3275                 3280                 3285             


Asp Gln  Leu Phe Arg Met Val  Ala Glu Val Phe Ile  Leu Trp Cys 
    3290                 3295                 3300             


Lys Ser  His Asn Phe Lys Arg  Glu Glu Gln Asn Phe  Val Ile Gln 
    3305                 3310                 3315             


Asn Glu  Ile Asn Asn Leu Ala  Phe Leu Thr Gly Asp  Ser Lys Ser 
    3320                 3325                 3330             


Lys Met  Ser Lys Ala Met Gln  Val Lys Ser Gly Gly  Gln Asp Gln 
    3335                 3340                 3345             


Glu Arg  Lys Lys Thr Lys Arg  Arg Gly Asp Leu Tyr  Ser Ile Gln 
    3350                 3355                 3360             


Thr Ser  Leu Ile Val Ala Ala  Leu Lys Lys Met Leu  Pro Ile Gly 
    3365                 3370                 3375             


Leu Asn  Met Cys Thr Pro Gly  Asp Gln Glu Leu Ile  Ser Leu Ala 
    3380                 3385                 3390             


Lys Ser  Arg Tyr Ser His Arg  Asp Thr Asp Glu Glu  Val Arg Glu 
    3395                 3400                 3405             


His Leu  Arg Asn Asn Leu His  Leu Gln Glu Lys Ser  Asp Asp Pro 
    3410                 3415                 3420             


Ala Val  Lys Trp Gln Leu Asn  Leu Tyr Lys Asp Val  Leu Lys Ser 
    3425                 3430                 3435             


Glu Glu  Pro Phe Asn Pro Glu  Lys Thr Val Glu Arg  Val Gln Arg 
    3440                 3445                 3450             


Ile Ser  Ala Ala Val Phe His  Leu Glu Gln Val Glu  Gln Pro Leu 
    3455                 3460                 3465             


Arg Ser  Lys Lys Ala Val Trp  His Lys Leu Leu Ser  Lys Gln Arg 
    3470                 3475                 3480             


Lys Arg  Ala Val Val Ala Cys  Phe Arg Met Ala Pro  Leu Tyr Asn 
    3485                 3490                 3495             


Leu Pro  Arg His Arg Ser Ile  Asn Leu Phe Leu His  Gly Tyr Gln 
    3500                 3505                 3510             


Arg Phe  Trp Ile Glu Thr Glu  Glu Tyr Ser Phe Glu  Glu Lys Leu 
    3515                 3520                 3525             


Val Gln  Asp Leu Ala Lys Ser  Pro Lys Val Glu Glu  Glu Glu Glu 
    3530                 3535                 3540             


Glu Glu  Thr Glu Lys Gln Pro  Asp Pro Leu His Gln  Ile Ile Leu 
    3545                 3550                 3555             


Tyr Phe  Ser Arg Asn Ala Leu  Thr Glu Arg Ser Lys  Leu Glu Asp 
    3560                 3565                 3570             


Asp Pro  Leu Tyr Thr Ser Tyr  Ser Ser Met Met Ala  Lys Ser Cys 
    3575                 3580                 3585             


Gln Ser  Gly Glu Asp Glu Glu  Glu Asp Glu Asp Lys  Glu Lys Thr 
    3590                 3595                 3600             


Phe Glu  Glu Lys Glu Met Glu  Lys Gln Lys Thr Leu  Tyr Gln Gln 
    3605                 3610                 3615             


Ala Arg  Leu His Glu Arg Gly  Ala Ala Glu Met Val  Leu Gln Met 
    3620                 3625                 3630             


Ile Ser  Ala Ser Lys Gly Glu  Met Ser Pro Met Val  Val Glu Thr 
    3635                 3640                 3645             


Leu Lys  Leu Gly Ile Ala Ile  Leu Asn Gly Gly Asn  Ala Gly Val 
    3650                 3655                 3660             


Gln Gln  Lys Met Leu Asp Tyr  Leu Lys Glu Lys Lys  Asp Ala Gly 
    3665                 3670                 3675             


Phe Phe  Gln Ser Leu Ser Gly  Leu Met Gln Ser Cys  Ser Val Leu 
    3680                 3685                 3690             


Asp Leu  Asn Ala Phe Glu Arg  Gln Asn Lys Ala Glu  Gly Leu Gly 
    3695                 3700                 3705             


Met Val  Thr Glu Glu Gly Thr  Leu Ile Val Arg Glu  Arg Gly Glu 
    3710                 3715                 3720             


Lys Val  Leu Gln Asn Asp Glu  Phe Thr Arg Asp Leu  Phe Arg Phe 
    3725                 3730                 3735             


Leu Gln  Leu Leu Cys Glu Gly  His Asn Ser Asp Phe  Gln Asn Phe 
    3740                 3745                 3750             


Leu Arg  Thr Gln Met Gly Asn  Thr Thr Thr Val Asn  Val Ile Ile 
    3755                 3760                 3765             


Ser Thr  Val Asp Tyr Leu Leu  Arg Leu Gln Glu Ser  Ile Ser Asp 
    3770                 3775                 3780             


Phe Tyr  Trp Tyr Tyr Ser Gly  Lys Asp Ile Ile Asp  Glu Ser Gly 
    3785                 3790                 3795             


Gln His  Asn Phe Ser Lys Ala  Leu Ala Val Thr Lys  Gln Ile Phe 
    3800                 3805                 3810             


Asn Ser  Leu Thr Glu Tyr Ile  Gln Gly Pro Cys Ile  Gly Asn Gln 
    3815                 3820                 3825             


Gln Ser  Leu Ala His Ser Arg  Leu Trp Asp Ala Val  Val Gly Phe 
    3830                 3835                 3840             


Leu His  Val Phe Ala Asn Met  Gln Met Lys Leu Ser  Gln Asp Ser 
    3845                 3850                 3855             


Ser Gln  Ile Glu Leu Leu Lys  Glu Leu Leu Asp Leu  Leu Gln Asp 
    3860                 3865                 3870             


Met Val  Val Met Leu Leu Ser  Leu Leu Glu Gly Asn  Val Val Asn 
    3875                 3880                 3885             


Gly Thr  Ile Gly Lys Gln Met  Val Asp Thr Leu Val  Glu Ser Ser 
    3890                 3895                 3900             


Thr Asn  Val Glu Met Ile Leu  Lys Phe Phe Asp Met  Phe Leu Lys 
    3905                 3910                 3915             


Leu Lys  Asp Leu Thr Ser Ser  Asp Thr Phe Lys Glu  Tyr Asp Pro 
    3920                 3925                 3930             


Asp Gly  Lys Gly Ile Ile Ser  Lys Lys Glu Phe Gln  Lys Ala Met 
    3935                 3940                 3945             


Glu Gly  Gln Lys Gln Tyr Thr  Gln Ser Glu Ile Asp  Phe Leu Leu 
    3950                 3955                 3960             


Ser Cys  Ala Glu Ala Asp Glu  Asn Asp Met Phe Asn  Tyr Val Asp 
    3965                 3970                 3975             


Phe Val  Asp Arg Phe His Glu  Pro Ala Lys Asp Ile  Gly Phe Asn 
    3980                 3985                 3990             


Val Ala  Val Leu Leu Thr Asn  Leu Ser Glu His Met  Pro Asn Asp 
    3995                 4000                 4005             


Ser Arg  Leu Lys Cys Leu Leu  Asp Pro Ala Glu Ser  Val Leu Asn 
    4010                 4015                 4020             


Tyr Phe  Glu Pro Tyr Leu Gly  Arg Ile Glu Ile Met  Gly Gly Ala 
    4025                 4030                 4035             


Lys Lys  Ile Glu Arg Val Tyr  Phe Glu Ile Ser Glu  Ser Ser Arg 
    4040                 4045                 4050             


Thr Gln  Trp Glu Lys Pro Gln  Val Lys Glu Ser Lys  Arg Gln Phe 
    4055                 4060                 4065             


Ile Phe  Asp Val Val Asn Glu  Gly Gly Glu Gln Glu  Lys Met Glu 
    4070                 4075                 4080             


Leu Phe  Val Asn Phe Cys Glu  Asp Thr Ile Phe Glu  Met Gln Leu 
    4085                 4090                 4095             


Ala Ser  Gln Ile Ser Glu Ser  Asp Ser Ala Asp Arg  Pro Glu Glu 
    4100                 4105                 4110             


Glu Glu  Glu Asp Glu Asp Ser  Ser Tyr Val Leu Glu  Ile Ala Gly 
    4115                 4120                 4125             


Glu Glu  Glu Glu Asp Gly Ser  Leu Glu Pro Ala Ser  Ala Phe Ala 
    4130                 4135                 4140             


Met Ala  Cys Ala Ser Val Lys  Arg Asn Val Thr Asp  Phe Leu Lys 
    4145                 4150                 4155             


Arg Ala  Thr Leu Lys Asn Leu  Arg Lys Gln Tyr Arg  Asn Val Lys 
    4160                 4165                 4170             


Lys Met  Thr Ala Lys Glu Leu  Val Lys Val Leu Phe  Ser Phe Phe 
    4175                 4180                 4185             


Trp Met  Leu Phe Val Gly Leu  Phe Gln Leu Leu Phe  Thr Ile Leu 
    4190                 4195                 4200             


Gly Gly  Ile Phe Gln Ile Leu  Trp Ser Thr Val Phe  Gly Gly Gly 
    4205                 4210                 4215             


Leu Val  Glu Gly Ala Lys Asn  Ile Arg Val Thr Lys  Ile Leu Gly 
    4220                 4225                 4230             


Asp Met  Pro Asp Pro Thr Gln  Phe Gly Ile His Asp  Asp Thr Met 
    4235                 4240                 4245             


Glu Ala  Glu Arg Ala Glu Val  Met Glu Pro Gly Ile  Thr Thr Glu 
    4250                 4255                 4260             


Leu Val  His Phe Ile Lys Gly  Glu Lys Gly Asp Thr  Asp Ile Met 
    4265                 4270                 4275             


Ser Asp  Leu Phe Gly Leu His  Pro Lys Lys Glu Gly  Ser Leu Lys 
    4280                 4285                 4290             


His Gly  Pro Glu Val Gly Leu  Gly Asp Leu Ser Glu  Ile Ile Gly 
    4295                 4300                 4305             


Lys Asp  Glu Pro Pro Thr Leu  Glu Ser Thr Val Gln  Lys Lys Arg 
    4310                 4315                 4320             


Lys Ala  Gln Ala Ala Glu Met  Lys Ala Ala Asn Glu  Ala Glu Gly 
    4325                 4330                 4335             


Lys Val  Glu Ser Glu Lys Ala  Asp Met Glu Asp Gly  Glu Lys Glu 
    4340                 4345                 4350             


Asp Lys  Asp Lys Glu Glu Glu  Gln Ala Glu Tyr Leu  Trp Thr Glu 
    4355                 4360                 4365             


Val Thr  Lys Lys Lys Lys Arg  Arg Cys Gly Gln Lys  Val Glu Lys 
    4370                 4375                 4380             


Pro Glu  Ala Phe Thr Ala Asn  Phe Phe Lys Gly Leu  Glu Ile Tyr 
    4385                 4390                 4395             


Gln Thr  Lys Leu Leu His Tyr  Leu Ala Arg Asn Phe  Tyr Asn Leu 
    4400                 4405                 4410             


Arg Phe  Leu Ala Leu Phe Val  Ala Phe Ala Ile Asn  Phe Ile Leu 
    4415                 4420                 4425             


Leu Phe  Tyr Lys Val Thr Glu  Glu Pro Leu Glu Glu  Glu Thr Glu 
    4430                 4435                 4440             


Asp Val  Ala Asn Leu Trp Asn  Ser Phe Asn Asp Glu  Glu Glu Glu 
    4445                 4450                 4455             


Glu Ala  Met Val Phe Phe Val  Leu Gln Glu Ser Thr  Gly Tyr Met 
    4460                 4465                 4470             


Ala Pro  Thr Leu Arg Ala Leu  Ala Ile Ile His Thr  Ile Ile Ser 
    4475                 4480                 4485             


Leu Val  Cys Val Val Gly Tyr  Tyr Cys Leu Lys Val  Pro Leu Val 
    4490                 4495                 4500             


Val Phe  Lys Arg Glu Lys Glu  Ile Ala Arg Lys Leu  Glu Phe Asp 
    4505                 4510                 4515             


Gly Leu  Tyr Ile Thr Glu Gln  Pro Ser Glu Asp Asp  Ile Lys Gly 
    4520                 4525                 4530             


Gln Trp  Asp Arg Leu Val Ile  Asn Thr Pro Ser Phe  Pro Asn Asn 
    4535                 4540                 4545             


Tyr Trp  Asp Lys Phe Val Lys  Arg Lys Val Ile Asn  Lys Tyr Gly 
    4550                 4555                 4560             


Asp Leu  Tyr Gly Ala Glu Arg  Ile Ala Glu Leu Leu  Gly Leu Asp 
    4565                 4570                 4575             


Lys Asn  Ala Leu Asp Phe Ser  Pro Val Glu Glu Thr  Lys Ala Glu 
    4580                 4585                 4590             


Ala Ala  Ser Leu Val Ser Trp  Leu Ser Ser Ile Asp  Met Lys Tyr 
    4595                 4600                 4605             


His Ile  Trp Lys Leu Gly Val  Val Phe Thr Asp Asn  Ser Phe Leu 
    4610                 4615                 4620             


Tyr Leu  Ala Trp Tyr Thr Thr  Met Ser Val Leu Gly  His Tyr Asn 
    4625                 4630                 4635             


Asn Phe  Phe Phe Ala Ala His  Leu Leu Asp Ile Ala  Met Gly Phe 
    4640                 4645                 4650             


Lys Thr  Leu Arg Thr Ile Leu  Ser Ser Val Thr His  Asn Gly Lys 
    4655                 4660                 4665             


Gln Leu  Val Leu Thr Val Gly  Leu Leu Ala Val Val  Val Tyr Leu 
    4670                 4675                 4680             


Tyr Thr  Val Val Ala Phe Asn  Phe Phe Arg Lys Phe  Tyr Asn Lys 
    4685                 4690                 4695             


Ser Glu  Asp Asp Asp Glu Pro  Asp Met Lys Cys Asp  Asp Met Met 
    4700                 4705                 4710             


Thr Cys  Tyr Leu Phe His Met  Tyr Val Gly Val Arg  Ala Gly Gly 
    4715                 4720                 4725             


Gly Ile  Gly Asp Glu Ile Glu  Asp Pro Ala Gly Asp  Pro Tyr Glu 
    4730                 4735                 4740             


Met Tyr  Arg Ile Val Phe Asp  Ile Thr Phe Phe Phe  Phe Val Ile 
    4745                 4750                 4755             


Val Ile  Leu Leu Ala Ile Ile  Gln Gly Leu Ile Ile  Asp Ala Phe 
    4760                 4765                 4770             


Gly Glu  Leu Arg Asp Gln Gln  Glu Gln Val Arg Glu  Asp Met Glu 
    4775                 4780                 4785             


Thr Lys  Cys Phe Ile Cys Gly  Ile Gly Asn Asp Tyr  Phe Asp Thr 
    4790                 4795                 4800             


Thr Pro  His Gly Phe Glu Thr  His Thr Leu Gln Glu  His Asn Leu 
    4805                 4810                 4815             


Ala Asn  Tyr Leu Phe Phe Leu  Met Tyr Leu Ile Asn  Lys Asp Glu 
    4820                 4825                 4830             


Thr Glu  His Thr Gly Gln Glu  Ser Tyr Val Trp Lys  Met Tyr Gln 
    4835                 4840                 4845             


Glu Arg  Cys Trp Asp Phe Phe  Pro Ala Gly Asp Cys  Phe Arg Lys 
    4850                 4855                 4860             


Gln Tyr  Glu Asp Gln Leu Gly  
    4865                 4870 


<210>  737
<211>  1149
<212>  PRT
<213>  Homo sapiens

<400>  737

Met Phe Gln Thr Lys Leu Arg Asn Glu Thr Trp Glu Asp Leu Pro Lys 
1               5                   10                  15      


Met Ser Cys Thr Thr Glu Ile Gln Ala Ala Phe Ile Leu Ser Ser Phe 
            20                  25                  30          


Val Thr Phe Phe Ser Gly Leu Ile Ile Leu Leu Ile Phe Arg Leu Ile 
        35                  40                  45              


Trp Arg Ser Val Lys Lys Trp Gln Ile Ile Lys Gly Thr Gly Ile Ile 
    50                  55                  60                  


Leu Glu Leu Phe Thr Ser Gly Thr Ile Ala Arg Ser His Val Arg Ser 
65                  70                  75                  80  


Leu His Phe Gln Gly Gln Phe Arg Asp His Ile Glu Met Leu Leu Ser 
                85                  90                  95      


Ala Gln Thr Phe Val Gly Gln Val Leu Val Ile Leu Val Phe Val Leu 
            100                 105                 110         


Ser Ile Gly Ser Leu Ile Ile Tyr Phe Ile Asn Ser Ala Asp Pro Val 
        115                 120                 125             


Gly Ser Cys Ser Ser Tyr Glu Asp Lys Thr Ile Pro Ile Asp Leu Val 
    130                 135                 140                 


Phe Asn Ala Phe Phe Ser Phe Tyr Phe Gly Leu Arg Phe Met Ala Ala 
145                 150                 155                 160 


Asp Asp Lys Ile Lys Phe Trp Leu Glu Met Asn Ser Ile Val Asp Ile 
                165                 170                 175     


Phe Thr Ile Pro Pro Thr Phe Ile Ser Tyr Tyr Leu Lys Ser Asn Trp 
            180                 185                 190         


Leu Gly Leu Arg Phe Leu Arg Ala Leu Arg Leu Leu Glu Leu Pro Gln 
        195                 200                 205             


Ile Leu Gln Ile Leu Arg Ala Ile Lys Thr Ser Asn Ser Val Lys Phe 
    210                 215                 220                 


Ser Lys Leu Leu Ser Ile Ile Leu Ser Thr Trp Phe Thr Ala Ala Gly 
225                 230                 235                 240 


Phe Ile His Leu Val Glu Asn Ser Gly Asp Pro Trp Leu Lys Gly Arg 
                245                 250                 255     


Asn Ser Gln Asn Ile Ser Tyr Phe Glu Ser Ile Tyr Leu Val Met Ala 
            260                 265                 270         


Thr Thr Ser Thr Val Gly Phe Gly Asp Val Val Ala Lys Thr Ser Leu 
        275                 280                 285             


Gly Arg Thr Phe Ile Met Phe Phe Thr Leu Gly Ser Leu Ile Leu Phe 
    290                 295                 300                 


Ala Asn Tyr Ile Pro Glu Met Val Glu Leu Phe Ala Asn Lys Arg Lys 
305                 310                 315                 320 


Tyr Thr Ser Ser Tyr Glu Ala Leu Lys Gly Lys Lys Phe Ile Val Val 
                325                 330                 335     


Cys Gly Asn Ile Thr Val Asp Ser Val Thr Ala Phe Leu Arg Asn Phe 
            340                 345                 350         


Leu Arg Asp Lys Ser Gly Glu Ile Asn Thr Glu Ile Val Phe Leu Gly 
        355                 360                 365             


Glu Thr Pro Pro Ser Leu Glu Leu Glu Thr Ile Phe Lys Cys Tyr Leu 
    370                 375                 380                 


Ala Tyr Thr Thr Phe Ile Ser Gly Ser Ala Met Lys Trp Glu Asp Leu 
385                 390                 395                 400 


Arg Arg Val Ala Val Glu Ser Ala Glu Ala Cys Leu Ile Ile Ala Asn 
                405                 410                 415     


Pro Leu Cys Ser Asp Ser His Ala Glu Asp Ile Ser Asn Ile Met Arg 
            420                 425                 430         


Val Leu Ser Ile Lys Asn Tyr Asp Ser Thr Thr Arg Ile Ile Ile Gln 
        435                 440                 445             


Ile Leu Gln Ser His Asn Lys Val Tyr Leu Pro Lys Ile Pro Ser Trp 
    450                 455                 460                 


Asn Trp Asp Thr Gly Asp Asn Ile Ile Cys Phe Ala Glu Leu Lys Leu 
465                 470                 475                 480 


Gly Phe Ile Ala Gln Gly Cys Leu Val Pro Gly Leu Cys Thr Phe Leu 
                485                 490                 495     


Thr Ser Leu Phe Val Glu Gln Asn Lys Lys Val Met Pro Lys Gln Thr 
            500                 505                 510         


Trp Lys Lys His Phe Leu Asn Ser Met Lys Asn Lys Ile Leu Thr Gln 
        515                 520                 525             


Arg Leu Ser Asp Asp Phe Ala Gly Met Ser Phe Pro Glu Val Ala Arg 
    530                 535                 540                 


Leu Cys Phe Leu Lys Met His Leu Leu Leu Ile Ala Ile Glu Tyr Lys 
545                 550                 555                 560 


Ser Leu Phe Thr Asp Gly Phe Cys Gly Leu Ile Leu Asn Pro Pro Pro 
                565                 570                 575     


Gln Val Arg Ile Arg Lys Asn Thr Leu Gly Phe Phe Ile Ala Glu Thr 
            580                 585                 590         


Pro Lys Asp Val Arg Arg Ala Leu Phe Tyr Cys Ser Val Cys His Asp 
        595                 600                 605             


Asp Val Phe Ile Pro Glu Leu Ile Thr Asn Cys Gly Cys Lys Ser Arg 
    610                 615                 620                 


Ser Arg Gln His Ile Thr Val Pro Ser Val Lys Arg Met Lys Lys Cys 
625                 630                 635                 640 


Leu Lys Gly Ile Ser Ser Arg Ile Ser Gly Gln Asp Ser Pro Pro Arg 
                645                 650                 655     


Val Ser Ala Ser Thr Ser Ser Ile Ser Asn Phe Thr Thr Arg Thr Leu 
            660                 665                 670         


Gln His Asp Val Glu Gln Asp Ser Asp Gln Leu Asp Ser Ser Gly Met 
        675                 680                 685             


Phe His Trp Cys Lys Pro Thr Ser Leu Asp Lys Val Thr Leu Lys Arg 
    690                 695                 700                 


Thr Gly Lys Ser Lys Tyr Lys Phe Arg Asn His Ile Val Ala Cys Val 
705                 710                 715                 720 


Phe Gly Asp Ala His Ser Ala Pro Met Gly Leu Arg Asn Phe Val Met 
                725                 730                 735     


Pro Leu Arg Ala Ser Asn Tyr Thr Arg Lys Glu Leu Lys Asp Ile Val 
            740                 745                 750         


Phe Ile Gly Ser Leu Asp Tyr Leu Gln Arg Glu Trp Arg Phe Leu Trp 
        755                 760                 765             


Asn Phe Pro Gln Ile Tyr Ile Leu Pro Gly Cys Ala Leu Tyr Ser Gly 
    770                 775                 780                 


Asp Leu His Ala Ala Asn Ile Glu Gln Cys Ser Met Cys Ala Val Leu 
785                 790                 795                 800 


Ser Pro Pro Pro Gln Pro Ser Ser Asn Gln Thr Leu Val Asp Thr Glu 
                805                 810                 815     


Ala Ile Met Ala Thr Leu Thr Ile Gly Ser Leu Gln Ile Asp Ser Ser 
            820                 825                 830         


Ser Asp Pro Ser Pro Ser Val Ser Glu Glu Thr Pro Gly Tyr Thr Asn 
        835                 840                 845             


Gly His Asn Glu Lys Ser Asn Cys Arg Lys Val Pro Ile Leu Thr Glu 
    850                 855                 860                 


Leu Lys Asn Pro Ser Asn Ile His Phe Ile Glu Gln Leu Gly Gly Leu 
865                 870                 875                 880 


Glu Gly Ser Leu Gln Glu Thr Asn Leu His Leu Ser Thr Ala Phe Ser 
                885                 890                 895     


Thr Gly Thr Val Phe Ser Gly Ser Phe Leu Asp Ser Leu Leu Ala Thr 
            900                 905                 910         


Ala Phe Tyr Asn Tyr His Val Leu Glu Leu Leu Gln Met Leu Val Thr 
        915                 920                 925             


Gly Gly Val Ser Ser Gln Leu Glu Gln His Leu Asp Lys Asp Lys Val 
    930                 935                 940                 


Tyr Gly Val Ala Asp Ser Cys Thr Ser Leu Leu Ser Gly Arg Asn Arg 
945                 950                 955                 960 


Cys Lys Leu Gly Leu Leu Ser Leu His Glu Thr Ile Leu Ser Asp Val 
                965                 970                 975     


Asn Pro Arg Asn Thr Phe Gly Gln Leu Phe Cys Gly Ser Leu Asp Leu 
            980                 985                 990         


Phe Gly Ile Leu Cys Val Gly Leu  Tyr Arg Ile Ile Asp  Glu Glu Glu 
        995                 1000                 1005             


Leu Asn  Pro Glu Asn Lys Arg  Phe Val Ile Thr Arg  Pro Ala Asn 
    1010                 1015                 1020             


Glu Phe  Lys Leu Leu Pro Ser  Asp Leu Val Phe Cys  Ala Ile Pro 
    1025                 1030                 1035             


Phe Ser  Thr Ala Cys Tyr Lys  Arg Asn Glu Glu Phe  Ser Leu Gln 
    1040                 1045                 1050             


Lys Ser  Tyr Glu Ile Val Asn  Lys Ala Ser Gln Thr  Thr Glu Thr 
    1055                 1060                 1065             


His Ser  Asp Thr Asn Cys Pro  Pro Thr Ile Asp Ser  Val Thr Glu 
    1070                 1075                 1080             


Thr Leu  Tyr Ser Pro Val Tyr  Ser Tyr Gln Pro Arg  Thr Asn Ser 
    1085                 1090                 1095             


Leu Ser  Phe Pro Lys Gln Ile  Ala Trp Asn Gln Ser  Arg Thr Asn 
    1100                 1105                 1110             


Ser Ile  Ile Ser Ser Gln Ile  Pro Leu Gly Asp Asn  Ala Lys Glu 
    1115                 1120                 1125             


Asn Glu  Arg Lys Thr Ser Asp  Glu Val Tyr Asp Glu  Asp Pro Phe 
    1130                 1135                 1140             


Ala Tyr  Ser Glu Pro Leu 
    1145                 


<210>  738
<211>  756
<212>  PRT
<213>  Homo sapiens

<400>  738

Met Ala Glu Ala His Gln Ala Val Ala Phe Gln Phe Thr Val Thr Pro 
1               5                   10                  15      


Asp Gly Ile Asp Leu Arg Leu Ser His Glu Ala Leu Arg Gln Ile Tyr 
            20                  25                  30          


Leu Ser Gly Leu His Ser Trp Lys Lys Lys Phe Ile Arg Phe Lys Asn 
        35                  40                  45              


Gly Ile Ile Thr Gly Val Tyr Pro Ala Ser Pro Ser Ser Trp Leu Ile 
    50                  55                  60                  


Val Val Val Gly Val Met Thr Thr Met Tyr Ala Lys Ile Asp Pro Ser 
65                  70                  75                  80  


Leu Gly Ile Ile Ala Lys Ile Asn Arg Thr Leu Glu Thr Ala Asn Cys 
                85                  90                  95      


Met Ser Ser Gln Thr Lys Asn Val Val Ser Gly Val Leu Phe Gly Thr 
            100                 105                 110         


Gly Leu Trp Val Ala Leu Ile Val Thr Met Arg Tyr Ser Leu Lys Val 
        115                 120                 125             


Leu Leu Ser Tyr His Gly Trp Met Phe Thr Glu His Gly Lys Met Ser 
    130                 135                 140                 


Arg Ala Thr Lys Ile Trp Met Gly Met Val Lys Ile Phe Ser Gly Arg 
145                 150                 155                 160 


Lys Pro Met Leu Tyr Ser Phe Gln Thr Ser Leu Pro Arg Leu Pro Val 
                165                 170                 175     


Pro Ala Val Lys Asp Thr Val Asn Arg Tyr Leu Gln Ser Val Arg Pro 
            180                 185                 190         


Leu Met Lys Glu Glu Asp Phe Lys Arg Met Thr Ala Leu Ala Gln Asp 
        195                 200                 205             


Phe Ala Val Gly Leu Gly Pro Arg Leu Gln Trp Tyr Leu Lys Leu Lys 
    210                 215                 220                 


Ser Trp Trp Ala Thr Asn Tyr Val Ser Asp Trp Trp Glu Glu Tyr Ile 
225                 230                 235                 240 


Tyr Leu Arg Gly Arg Gly Pro Leu Met Val Asn Ser Asn Tyr Tyr Ala 
                245                 250                 255     


Met Asp Leu Leu Tyr Ile Leu Pro Thr His Ile Gln Ala Ala Arg Ala 
            260                 265                 270         


Gly Asn Ala Ile His Ala Ile Leu Leu Tyr Arg Arg Lys Leu Asp Arg 
        275                 280                 285             


Glu Glu Ile Lys Pro Ile Arg Leu Leu Gly Ser Thr Ile Pro Leu Cys 
    290                 295                 300                 


Ser Ala Gln Trp Glu Arg Met Phe Asn Thr Ser Arg Ile Pro Gly Glu 
305                 310                 315                 320 


Glu Thr Asp Thr Ile Gln His Met Arg Asp Ser Lys His Ile Val Val 
                325                 330                 335     


Tyr His Arg Gly Arg Tyr Phe Lys Val Trp Leu Tyr His Asp Gly Arg 
            340                 345                 350         


Leu Leu Lys Pro Arg Glu Met Glu Gln Gln Met Gln Arg Ile Leu Asp 
        355                 360                 365             


Asn Thr Ser Glu Pro Gln Pro Gly Glu Ala Arg Leu Ala Ala Leu Thr 
    370                 375                 380                 


Ala Gly Asp Arg Val Pro Trp Ala Arg Cys Arg Gln Ala Tyr Phe Gly 
385                 390                 395                 400 


Arg Gly Lys Asn Lys Gln Ser Leu Asp Ala Val Glu Lys Ala Ala Phe 
                405                 410                 415     


Phe Val Thr Leu Asp Glu Thr Glu Glu Gly Tyr Arg Ser Glu Asp Pro 
            420                 425                 430         


Asp Thr Ser Met Asp Ser Tyr Ala Lys Ser Leu Leu His Gly Arg Cys 
        435                 440                 445             


Tyr Asp Arg Trp Phe Asp Lys Ser Phe Thr Phe Val Val Phe Lys Asn 
    450                 455                 460                 


Gly Lys Met Gly Leu Asn Ala Glu His Ser Trp Ala Asp Ala Pro Ile 
465                 470                 475                 480 


Val Ala His Leu Trp Glu Tyr Val Met Ser Ile Asp Ser Leu Gln Leu 
                485                 490                 495     


Gly Tyr Ala Glu Asp Gly His Cys Lys Gly Asp Ile Asn Pro Asn Ile 
            500                 505                 510         


Pro Tyr Pro Thr Arg Leu Gln Trp Asp Ile Pro Gly Glu Cys Gln Glu 
        515                 520                 525             


Val Ile Glu Thr Ser Leu Asn Thr Ala Asn Leu Leu Ala Asn Asp Val 
    530                 535                 540                 


Asp Phe His Ser Phe Pro Phe Val Ala Phe Gly Lys Gly Ile Ile Lys 
545                 550                 555                 560 


Lys Cys Arg Thr Ser Pro Asp Ala Phe Val Gln Leu Ala Leu Gln Leu 
                565                 570                 575     


Ala His Tyr Lys Asp Met Gly Lys Phe Cys Leu Thr Tyr Glu Ala Ser 
            580                 585                 590         


Met Thr Arg Leu Phe Arg Glu Gly Arg Thr Glu Thr Val Arg Ser Cys 
        595                 600                 605             


Thr Thr Glu Ser Cys Asp Phe Val Arg Ala Met Val Asp Pro Ala Gln 
    610                 615                 620                 


Thr Val Glu Gln Arg Leu Lys Leu Phe Lys Leu Ala Ser Glu Lys His 
625                 630                 635                 640 


Gln His Met Tyr Arg Leu Ala Met Thr Gly Ser Gly Ile Asp Arg His 
                645                 650                 655     


Leu Phe Cys Leu Tyr Val Val Ser Lys Tyr Leu Ala Val Glu Ser Pro 
            660                 665                 670         


Phe Leu Lys Glu Val Leu Ser Glu Pro Trp Arg Leu Ser Thr Ser Gln 
        675                 680                 685             


Thr Pro Gln Gln Gln Val Glu Leu Phe Asp Leu Glu Asn Asn Pro Glu 
    690                 695                 700                 


Tyr Val Ser Ser Gly Gly Gly Phe Gly Pro Val Ala Asp Asp Gly Tyr 
705                 710                 715                 720 


Gly Val Ser Tyr Ile Leu Val Gly Glu Asn Leu Ile Asn Phe His Ile 
                725                 730                 735     


Ser Ser Lys Phe Ser Cys Pro Glu Thr Gly Ile Ile Ser Gln Gly Pro 
            740                 745                 750         


Ser Ser Asp Thr 
        755     


<210>  739
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  739

Met Pro Glu Phe Leu Glu Asp Pro Ser Val Leu Thr Lys Asp Lys Leu 
1               5                   10                  15      


Lys Ser Glu Leu Val Ala Asn Asn Val Thr Leu Pro Ala Gly Glu Gln 
            20                  25                  30          


Arg Lys Asp Val Tyr Val Gln Leu Tyr Leu Gln His Leu Thr Ala Arg 
        35                  40                  45              


Asn Arg Pro Pro Leu Pro Ala Gly Thr Asn Ser Lys Gly Pro Pro Asp 
    50                  55                  60                  


Phe Ser Ser Asp Glu Glu Arg Glu Pro Thr Pro Val Leu Gly Ser Gly 
65                  70                  75                  80  


Ala Ala Ala Ala Gly Arg Ser Arg Ala Ala Val Gly Arg Lys Ala Thr 
                85                  90                  95      


Lys Lys Thr Asp Lys Pro Arg Gln Glu Asp Lys Asp Asp Leu Asp Val 
            100                 105                 110         


Thr Glu Leu Thr Asn Glu Asp Leu Leu Asp Gln Leu Val Lys Tyr Gly 
        115                 120                 125             


Val Asn Pro Gly Pro Ile Val Gly Thr Thr Arg Lys Leu Tyr Glu Lys 
    130                 135                 140                 


Lys Leu Leu Lys Leu Arg Glu Gln Gly Thr Glu Ser Arg Ser Ser Thr 
145                 150                 155                 160 


Pro Leu Pro Thr Ile Ser Ser Ser Ala Glu Asn Thr Arg Gln Asn Gly 
                165                 170                 175     


Ser Asn Asp Ser Asp Arg Tyr Ser Asp Asn Glu Glu Asp Ser Lys Ile 
            180                 185                 190         


Glu Leu Lys Leu Glu Lys Arg Glu Pro Leu Lys Gly Arg Ala Lys Thr 
        195                 200                 205             


Pro Val Thr Leu Lys Gln Arg Arg Val Glu His Asn Gln Ser Tyr Ser 
    210                 215                 220                 


Gln Ala Gly Ile Thr Glu Thr Glu Trp Thr Ser Gly Ser Ser Lys Gly 
225                 230                 235                 240 


Gly Pro Leu Gln Ala Leu Thr Arg Glu Ser Thr Arg Gly Ser Arg Arg 
                245                 250                 255     


Thr Pro Arg Lys Arg Val Glu Thr Ser Glu His Phe Arg Ile Asp Gly 
            260                 265                 270         


Pro Val Ile Ser Glu Ser Thr Pro Ile Ala Glu Thr Ile Met Ala Ser 
        275                 280                 285             


Ser Asn Glu Ser Leu Val Val Asn Arg Val Thr Gly Asn Phe Lys His 
    290                 295                 300                 


Ala Ser Pro Ile Leu Pro Ile Thr Glu Phe Ser Asp Ile Pro Arg Arg 
305                 310                 315                 320 


Ala Pro Lys Lys Pro Leu Thr Arg Ala Glu Val Gly Glu Lys Thr Glu 
                325                 330                 335     


Glu Arg Arg Val Glu Arg Asp Ile Leu Lys Glu Met Phe Pro Tyr Glu 
            340                 345                 350         


Ala Ser Thr Pro Thr Gly Ile Ser Ala Ser Cys Arg Arg Pro Ile Lys 
        355                 360                 365             


Gly Ala Ala Gly Arg Pro Leu Glu Leu Ser Asp Phe Arg Met Glu Glu 
    370                 375                 380                 


Ser Phe Ser Ser Lys Tyr Val Pro Lys Tyr Val Pro Leu Ala Asp Val 
385                 390                 395                 400 


Lys Ser Glu Lys Thr Lys Lys Gly Arg Ser Ile Pro Val Trp Ile Lys 
                405                 410                 415     


Ile Leu Leu Phe Val Val Val Ala Val Phe Leu Phe Leu Val Tyr Gln 
            420                 425                 430         


Ala Met Glu Thr Asn Gln Val Asn Pro Phe Ser Asn Phe Leu His Val 
        435                 440                 445             


Asp Pro Arg Lys Ser Asn 
    450                 


<210>  740
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  740

Met Pro Glu Phe Leu Glu Asp Pro Ser Val Leu Thr Lys Asp Lys Leu 
1               5                   10                  15      


Lys Ser Glu Leu Val Ala Asn Asn Val Thr Leu Pro Ala Gly Glu Gln 
            20                  25                  30          


Arg Lys Asp Val Tyr Val Gln Leu Tyr Leu Gln His Leu Thr Ala Arg 
        35                  40                  45              


Asn Arg Pro Pro Leu Pro Ala Gly Thr Asn Ser Lys Gly Pro Pro Asp 
    50                  55                  60                  


Phe Ser Ser Asp Glu Glu Arg Glu Pro Thr Pro Val Leu Gly Ser Gly 
65                  70                  75                  80  


Ala Ala Ala Ala Gly Arg Ser Arg Ala Ala Val Gly Arg Lys Ala Thr 
                85                  90                  95      


Lys Lys Thr Asp Lys Pro Arg Gln Glu Asp Lys Asp Asp Leu Asp Val 
            100                 105                 110         


Thr Glu Leu Thr Asn Glu Asp Leu Leu Asp Gln Leu Val Lys Tyr Gly 
        115                 120                 125             


Val Asn Pro Gly Pro Ile Val Gly Thr Thr Arg Lys Leu Tyr Glu Lys 
    130                 135                 140                 


Lys Leu Leu Lys Leu Arg Glu Gln Gly Thr Glu Ser Arg Ser Ser Thr 
145                 150                 155                 160 


Pro Leu Pro Thr Ile Ser Ser Ser Ala Glu Asn Thr Arg Gln Asn Gly 
                165                 170                 175     


Ser Asn Asp Ser Asp Arg Tyr Ser Asp Asn Glu Glu Asp Ser Lys Ile 
            180                 185                 190         


Glu Leu Lys Leu Glu Lys Arg Glu Pro Leu Lys Gly Arg Ala Lys Thr 
        195                 200                 205             


Pro Val Thr Leu Lys Gln Arg Arg Val Glu His Asn Gln Val Gly Glu 
    210                 215                 220                 


Lys Thr Glu Glu Arg Arg Val Glu Arg Asp Ile Leu Lys Glu Met Phe 
225                 230                 235                 240 


Pro Tyr Glu Ala Ser Thr Pro Thr Gly Ile Ser Ala Ser Cys Arg Arg 
                245                 250                 255     


Pro Ile Lys Gly Ala Ala Gly Arg Pro Leu Glu Leu Ser Asp Phe Arg 
            260                 265                 270         


Met Glu Glu Ser Phe Ser Ser Lys Tyr Val Pro Lys Tyr Val Pro Leu 
        275                 280                 285             


Ala Asp Val Lys Ser Glu Lys Thr Lys Lys Gly Arg Ser Ile Pro Val 
    290                 295                 300                 


Trp Ile Lys Ile Leu Leu Phe Val Val Val Ala Val Phe Leu Phe Leu 
305                 310                 315                 320 


Val Tyr Gln Ala Met Glu Thr Asn Gln Val Asn Pro Phe Ser Asn Phe 
                325                 330                 335     


Leu His Val Asp Pro Arg Lys Ser Asn 
            340                 345 


<210>  741
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  741

Met Ala Ala Thr Thr Gly Ser Gly Val Lys Val Pro Arg Asn Phe Arg 
1               5                   10                  15      


Leu Leu Glu Glu Leu Glu Glu Gly Gln Lys Gly Val Gly Asp Gly Thr 
            20                  25                  30          


Val Ser Trp Gly Leu Glu Asp Asp Glu Asp Met Thr Leu Thr Arg Trp 
        35                  40                  45              


Thr Gly Met Ile Ile Gly Pro Pro Arg Thr Ile Tyr Glu Asn Arg Ile 
    50                  55                  60                  


Tyr Ser Leu Lys Ile Glu Cys Gly Pro Lys Tyr Pro Glu Ala Pro Pro 
65                  70                  75                  80  


Phe Val Arg Phe Val Thr Lys Ile Asn Met Asn Gly Val Asn Ser Ser 
                85                  90                  95      


Asn Gly Val Val Asp Pro Arg Ala Ile Ser Val Leu Ala Lys Trp Gln 
            100                 105                 110         


Asn Ser Tyr Ser Ile Lys Val Val Leu Gln Glu Leu Arg Arg Leu Met 
        115                 120                 125             


Met Ser Lys Glu Asn Met Lys Leu Pro Gln Pro Pro Glu Gly Gln Cys 
    130                 135                 140                 


Tyr Ser Asn 
145         


<210>  742
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  742

Met Ala Ala Val Gly Ala Gly Gly Ser Thr Ala Ala Pro Gly Pro Gly 
1               5                   10                  15      


Ala Val Ser Ala Gly Ala Leu Glu Pro Gly Thr Ala Ser Ala Ala His 
            20                  25                  30          


Arg Arg Leu Lys Tyr Ile Ser Leu Ala Val Leu Val Val Gln Asn Ala 
        35                  40                  45              


Ser Leu Ile Leu Ser Ile Arg Tyr Ala Arg Thr Leu Pro Gly Asp Arg 
    50                  55                  60                  


Phe Phe Ala Thr Thr Ala Val Val Met Ala Glu Val Leu Lys Gly Leu 
65                  70                  75                  80  


Thr Cys Leu Leu Leu Leu Phe Ala Gln Lys Arg Gly Asn Val Lys His 
                85                  90                  95      


Leu Val Leu Phe Leu His Glu Ala Val Leu Val Gln Tyr Val Asp Thr 
            100                 105                 110         


Leu Lys Leu Ala Val Pro Ser Leu Ile Tyr Thr Leu Gln Asn Asn Leu 
        115                 120                 125             


Gln Tyr Val Ala Ile Ser Asn Leu Pro Ala Ala Thr Phe Gln Pro Ser 
    130                 135                 140                 


Pro Arg Cys Ser Gln Ser His Ser Leu Cys Leu Cys Leu Arg Leu Arg 
145                 150                 155                 160 


Ala Leu Arg Ser Pro Ala Ala Ser Arg Ala Ala Thr Thr Thr Ala Ala 
                165                 170                 175     


Val Phe Pro Pro Trp Arg Pro His His Gly Ala Leu Ser Ala Lys Val 
            180                 185                 190         


Ser Ala Gly Glu Val Arg Ala Gly Ser Asn Gly Gly Thr Gln Gly Arg 
        195                 200                 205             


Gly Thr Gly Val Glu Gly Val Gly His Leu Gln Asp Pro Ser Arg His 
    210                 215                 220                 


Pro Pro Gly Pro Gly Ser Ser Gly Phe Gly Arg Trp Ser Phe Leu Pro 
225                 230                 235                 240 


Gly His 
        


<210>  743
<211>  78
<212>  PRT
<213>  Homo sapiens

<400>  743

Met Ser Glu Ser Glu Leu Gly Arg Lys Trp Asp Arg Cys Leu Ala Asp 
1               5                   10                  15      


Ala Val Val Lys Ile Gly Thr Gly Phe Gly Leu Gly Ile Val Phe Ser 
            20                  25                  30          


Leu Thr Phe Phe Lys Arg Arg Met Trp Pro Leu Ala Phe Gly Ser Gly 
        35                  40                  45              


Met Gly Leu Gly Met Ala Tyr Ser Asn Cys Gln His Asp Phe Gln Ala 
    50                  55                  60                  


Pro Tyr Leu Leu His Gly Lys Tyr Val Lys Glu Gln Glu Gln 
65                  70                  75              


<210>  744
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  744

Met Ala Pro Ala Arg Thr Met Ala Arg Ala Arg Leu Ala Pro Ala Gly 
1               5                   10                  15      


Ile Pro Ala Val Ala Leu Trp Leu Leu Cys Thr Leu Gly Leu Gln Gly 
            20                  25                  30          


Thr Gln Ala Gly Pro Pro Pro Ala Pro Pro Gly Leu Pro Ala Gly Ala 
        35                  40                  45              


Asp Cys Leu Asn Ser Phe Thr Ala Gly Val Pro Gly Phe Val Leu Asp 
    50                  55                  60                  


Thr Asn Ala Ser Val Ser Asn Gly Ala Thr Phe Leu Glu Ser Pro Thr 
65                  70                  75                  80  


Val Arg Arg Gly Trp Asp Cys Val Arg Ala Cys Cys Thr Thr Gln Asn 
                85                  90                  95      


Cys Asn Leu Ala Leu Val Glu Leu Gln Pro Asp Arg Gly Glu Asp Ala 
            100                 105                 110         


Ile Ala Ala Cys Phe Leu Ile Asn Cys Leu Tyr Glu Gln Asn Phe Val 
        115                 120                 125             


Cys Lys Phe Ala Pro Arg Glu Gly Phe Ile Asn Tyr Leu Thr Arg Glu 
    130                 135                 140                 


Val Tyr Arg Ser Tyr Arg Gln Leu Arg Thr Gln Gly Phe Gly Gly Ser 
145                 150                 155                 160 


Gly Ile Pro Lys Ala Trp Ala Gly Ile Asp Leu Lys Val Gln Pro Gln 
                165                 170                 175     


Glu Pro Leu Val Leu Lys Asp Val Glu Asn Thr Asp Trp Arg Leu Leu 
            180                 185                 190         


Arg Gly Asp Thr Asp Val Arg Val Glu Arg Lys Asp Pro Asn Gln Val 
        195                 200                 205             


Glu Leu Trp Gly Leu Lys Glu Gly Thr Tyr Leu Phe Gln Leu Thr Val 
    210                 215                 220                 


Thr Ser Ser Asp His Pro Glu Asp Thr Ala Asn Val Thr Val Thr Val 
225                 230                 235                 240 


Leu Ser Thr Lys Gln Thr Glu Asp Tyr Cys Leu Ala Ser Asn Lys Val 
                245                 250                 255     


Gly Arg Cys Arg Gly Ser Phe Pro Arg Trp Tyr Tyr Asp Pro Thr Glu 
            260                 265                 270         


Gln Ile Cys Lys Ser Phe Val Tyr Gly Gly Cys Leu Gly Asn Lys Asn 
        275                 280                 285             


Asn Tyr Leu Arg Glu Glu Glu Cys Ile Leu Ala Cys Arg Gly Val Gln 
    290                 295                 300                 


Gly Pro Ser Met Glu Arg Arg His Pro Val Cys Ser Gly Thr Cys Gln 
305                 310                 315                 320 


Pro Thr Gln Phe Arg Cys Ser Asn Gly Cys Cys Ile Asp Ser Phe Leu 
                325                 330                 335     


Glu Cys Asp Asp Thr Pro Asn Cys Pro Asp Ala Ser Asp Glu Ala Ala 
            340                 345                 350         


Cys Glu Lys Tyr Thr Ser Gly Phe Asp Glu Leu Gln Arg Ile His Phe 
        355                 360                 365             


Pro Ser Asp Lys Gly His Cys Val Asp Leu Pro Asp Thr Gly Leu Cys 
    370                 375                 380                 


Lys Glu Ser Ile Pro Arg Trp Tyr Tyr Asn Pro Phe Ser Glu His Cys 
385                 390                 395                 400 


Ala Arg Phe Thr Tyr Gly Gly Cys Tyr Gly Asn Lys Asn Asn Phe Glu 
                405                 410                 415     


Glu Glu Gln Gln Cys Leu Glu Ser Cys Arg Gly Ile Ser Lys Lys Asp 
            420                 425                 430         


Val Phe Gly Leu Arg Arg Glu Ile Pro Ile Pro Ser Thr Gly Ser Val 
        435                 440                 445             


Glu Met Ala Val Ala Val Phe Leu Val Ile Cys Ile Val Val Val Val 
    450                 455                 460                 


Ala Ile Leu Gly Tyr Cys Phe Phe Lys Asn Gln Arg Lys Asp Phe His 
465                 470                 475                 480 


Gly His His His His Pro Pro Pro Thr Pro Ala Ser Ser Thr Val Ser 
                485                 490                 495     


Thr Thr Glu Asp Thr Glu His Leu Val Tyr Asn His Thr Thr Arg Pro 
            500                 505                 510         


Leu 
    


<210>  745
<211>  1193
<212>  PRT
<213>  Homo sapiens

<400>  745

Met Met Phe Arg Ser Asp Arg Met Trp Ser Cys His Trp Lys Trp Lys 
1               5                   10                  15      


Pro Ser Pro Leu Leu Phe Leu Phe Ala Leu Tyr Ile Met Cys Val Pro 
            20                  25                  30          


His Ser Val Trp Gly Cys Ala Asn Cys Arg Val Val Leu Ser Asn Pro 
        35                  40                  45              


Ser Gly Thr Phe Thr Ser Pro Cys Tyr Pro Asn Asp Tyr Pro Asn Ser 
    50                  55                  60                  


Gln Ala Cys Met Trp Thr Leu Arg Ala Pro Thr Gly Tyr Ile Ile Gln 
65                  70                  75                  80  


Ile Thr Phe Asn Asp Phe Asp Ile Glu Glu Ala Pro Asn Cys Ile Tyr 
                85                  90                  95      


Asp Ser Leu Ser Leu Asp Asn Gly Glu Ser Gln Thr Lys Phe Cys Gly 
            100                 105                 110         


Ala Thr Ala Lys Gly Leu Ser Phe Asn Ser Ser Ala Asn Glu Met His 
        115                 120                 125             


Val Ser Phe Ser Ser Asp Phe Ser Ile Gln Lys Lys Gly Phe Asn Ala 
    130                 135                 140                 


Ser Tyr Ile Arg Val Ala Val Ser Leu Arg Asn Gln Lys Val Ile Leu 
145                 150                 155                 160 


Pro Gln Thr Ser Asp Ala Tyr Gln Val Ser Val Ala Lys Ser Ile Ser 
                165                 170                 175     


Ile Pro Glu Leu Ser Ala Phe Thr Leu Cys Phe Glu Ala Thr Lys Val 
            180                 185                 190         


Gly His Glu Asp Ser Asp Trp Thr Ala Phe Ser Tyr Ser Asn Ala Ser 
        195                 200                 205             


Phe Thr Gln Leu Leu Ser Phe Gly Lys Ala Lys Ser Gly Tyr Phe Leu 
    210                 215                 220                 


Ser Ile Ser Asp Ser Lys Cys Leu Leu Asn Asn Ala Leu Pro Val Lys 
225                 230                 235                 240 


Glu Lys Glu Asp Ile Phe Ala Glu Ser Phe Glu Gln Leu Cys Leu Val 
                245                 250                 255     


Trp Asn Asn Ser Leu Gly Ser Ile Gly Val Asn Phe Lys Arg Asn Tyr 
            260                 265                 270         


Glu Thr Val Pro Cys Asp Ser Thr Ile Ser Lys Val Ile Pro Gly Asn 
        275                 280                 285             


Gly Lys Leu Leu Leu Gly Ser Asn Gln Asn Glu Ile Val Ser Leu Lys 
    290                 295                 300                 


Gly Asp Ile Tyr Asn Phe Arg Leu Trp Asn Phe Thr Met Asn Ala Lys 
305                 310                 315                 320 


Ile Leu Ser Asn Leu Ser Cys Asn Val Lys Gly Asn Val Val Asp Trp 
                325                 330                 335     


Gln Asn Asp Phe Trp Asn Ile Pro Asn Leu Ala Leu Lys Ala Glu Ser 
            340                 345                 350         


Asn Leu Ser Cys Gly Ser Tyr Leu Ile Pro Leu Pro Ala Ala Glu Leu 
        355                 360                 365             


Ala Ser Cys Ala Asp Leu Gly Thr Leu Cys Gln Asp Gly Ile Ile Tyr 
    370                 375                 380                 


Arg Ile Ser Val Val Ile Gln Asn Ile Leu Arg His Pro Glu Val Lys 
385                 390                 395                 400 


Val Gln Ser Lys Val Ala Glu Trp Leu Asn Ser Thr Phe Gln Asn Trp 
                405                 410                 415     


Asn Tyr Thr Val Tyr Val Val Asn Ile Ser Phe His Leu Ser Ala Gly 
            420                 425                 430         


Glu Asp Lys Ile Lys Val Lys Arg Ser Leu Glu Asp Glu Pro Arg Leu 
        435                 440                 445             


Val Leu Trp Ala Leu Leu Val Tyr Asn Ala Thr Asn Asn Thr Asn Leu 
    450                 455                 460                 


Glu Gly Lys Ile Ile Gln Gln Lys Leu Leu Lys Asn Asn Glu Ser Leu 
465                 470                 475                 480 


Asp Glu Gly Leu Arg Leu His Thr Val Asn Val Arg Gln Leu Gly His 
                485                 490                 495     


Cys Leu Ala Met Glu Glu Pro Lys Gly Tyr Tyr Trp Pro Ser Ile Gln 
            500                 505                 510         


Pro Ser Glu Tyr Val Leu Pro Cys Pro Asp Lys Pro Gly Phe Ser Ala 
        515                 520                 525             


Ser Arg Ile Cys Phe Tyr Asn Ala Thr Asn Pro Leu Val Thr Tyr Trp 
    530                 535                 540                 


Gly Pro Val Asp Ile Ser Asn Cys Leu Lys Glu Ala Asn Glu Val Ala 
545                 550                 555                 560 


Asn Gln Ile Leu Asn Leu Thr Ala Asp Gly Gln Asn Leu Thr Ser Ala 
                565                 570                 575     


Asn Ile Thr Asn Ile Val Glu Gln Val Lys Arg Ile Val Asn Lys Glu 
            580                 585                 590         


Glu Asn Ile Asp Ile Thr Leu Gly Ser Thr Leu Met Asn Ile Phe Ser 
        595                 600                 605             


Asn Ile Leu Ser Ser Ser Asp Ser Asp Leu Leu Glu Ser Ser Ser Glu 
    610                 615                 620                 


Ala Leu Lys Thr Ile Asp Glu Leu Ala Phe Lys Ile Asp Leu Asn Ser 
625                 630                 635                 640 


Thr Ser His Val Asn Ile Thr Thr Arg Asn Leu Ala Leu Ser Val Ser 
                645                 650                 655     


Ser Leu Leu Pro Gly Thr Asn Ala Ile Ser Asn Phe Ser Ile Gly Leu 
            660                 665                 670         


Pro Ser Asn Asn Glu Ser Tyr Phe Gln Met Asp Phe Glu Ser Gly Gln 
        675                 680                 685             


Val Asp Pro Leu Ala Ser Val Ile Leu Pro Pro Asn Leu Leu Glu Asn 
    690                 695                 700                 


Leu Ser Pro Glu Asp Ser Val Leu Val Arg Arg Ala Gln Phe Thr Phe 
705                 710                 715                 720 


Phe Asn Lys Thr Gly Leu Phe Gln Asp Val Gly Pro Gln Arg Lys Thr 
                725                 730                 735     


Leu Val Ser Tyr Val Met Ala Cys Ser Ile Gly Asn Ile Thr Ile Gln 
            740                 745                 750         


Asn Leu Lys Asp Pro Val Gln Ile Lys Ile Lys His Thr Arg Thr Gln 
        755                 760                 765             


Glu Val His His Pro Ile Cys Ala Phe Trp Asp Leu Asn Lys Asn Lys 
    770                 775                 780                 


Ser Phe Gly Gly Trp Asn Thr Ser Gly Cys Val Ala His Arg Asp Ser 
785                 790                 795                 800 


Asp Ala Ser Glu Thr Val Cys Leu Cys Asn His Phe Thr His Phe Gly 
                805                 810                 815     


Val Leu Met Asp Leu Pro Arg Ser Ala Ser Gln Leu Asp Ala Arg Asn 
            820                 825                 830         


Thr Lys Val Leu Thr Phe Ile Ser Tyr Ile Gly Cys Gly Ile Ser Ala 
        835                 840                 845             


Ile Phe Ser Ala Ala Thr Leu Leu Thr Tyr Val Ala Phe Glu Lys Leu 
    850                 855                 860                 


Arg Arg Asp Tyr Pro Ser Lys Ile Leu Met Asn Leu Ser Thr Ala Leu 
865                 870                 875                 880 


Leu Phe Leu Asn Leu Leu Phe Leu Leu Asp Gly Trp Ile Thr Ser Phe 
                885                 890                 895     


Asn Val Asp Gly Leu Cys Ile Ala Val Ala Val Leu Leu His Phe Phe 
            900                 905                 910         


Leu Leu Ala Thr Phe Thr Trp Met Gly Leu Glu Ala Ile His Met Tyr 
        915                 920                 925             


Ile Ala Leu Val Lys Val Phe Asn Thr Tyr Ile Arg Arg Tyr Ile Leu 
    930                 935                 940                 


Lys Phe Cys Ile Ile Gly Trp Gly Leu Pro Ala Leu Val Val Ser Val 
945                 950                 955                 960 


Val Leu Ala Ser Arg Asn Asn Asn Glu Val Tyr Gly Lys Glu Ser Tyr 
                965                 970                 975     


Gly Lys Glu Lys Gly Asp Glu Phe Cys Trp Ile Gln Asp Pro Val Ile 
            980                 985                 990         


Phe Tyr Val Thr Cys Ala Gly Tyr  Phe Gly Val Met Phe  Phe Leu Asn 
        995                 1000                 1005             


Ile Ala  Met Phe Ile Val Val  Met Val Gln Ile Cys  Gly Arg Asn 
    1010                 1015                 1020             


Gly Lys  Arg Ser Asn Arg Thr  Leu Arg Glu Glu Val  Leu Arg Asn 
    1025                 1030                 1035             


Leu Arg  Ser Val Val Ser Leu  Thr Phe Leu Leu Gly  Met Thr Trp 
    1040                 1045                 1050             


Gly Phe  Ala Phe Phe Ala Trp  Gly Pro Leu Asn Ile  Pro Phe Met 
    1055                 1060                 1065             


Tyr Leu  Phe Ser Ile Phe Asn  Ser Leu Gln Gly Leu  Phe Ile Phe 
    1070                 1075                 1080             


Ile Phe  His Cys Ala Met Lys  Glu Asn Val Gln Lys  Gln Trp Arg 
    1085                 1090                 1095             


Arg His  Leu Cys Cys Gly Arg  Phe Arg Leu Ala Asp  Asn Ser Asp 
    1100                 1105                 1110             


Trp Ser  Lys Thr Ala Thr Asn  Ile Ile Lys Lys Ser  Ser Asp Asn 
    1115                 1120                 1125             


Leu Gly  Lys Ser Leu Ser Ser  Ser Ser Ile Gly Ser  Asn Ser Thr 
    1130                 1135                 1140             


Tyr Leu  Thr Ser Lys Ser Lys  Ser Ser Ser Thr Thr  Tyr Phe Lys 
    1145                 1150                 1155             


Arg Asn  Ser His Thr Asp Asn  Val Ser Tyr Glu His  Ser Phe Asn 
    1160                 1165                 1170             


Lys Ser  Gly Ser Leu Arg Gln  Cys Phe His Gly Gln  Val Leu Val 
    1175                 1180                 1185             


Lys Thr  Gly Pro Cys 
    1190             


<210>  746
<211>  1222
<212>  PRT
<213>  Homo sapiens

<400>  746

Met Met Phe Arg Ser Asp Arg Met Trp Ser Cys His Trp Lys Trp Lys 
1               5                   10                  15      


Pro Ser Pro Leu Leu Phe Leu Phe Ala Leu Tyr Ile Met Cys Val Pro 
            20                  25                  30          


His Ser Val Trp Gly Cys Ala Asn Cys Arg Val Val Leu Ser Asn Pro 
        35                  40                  45              


Ser Gly Thr Phe Thr Ser Pro Cys Tyr Pro Asn Asp Tyr Pro Asn Ser 
    50                  55                  60                  


Gln Ala Cys Met Trp Thr Leu Arg Ala Pro Thr Gly Tyr Ile Ile Gln 
65                  70                  75                  80  


Ile Thr Phe Asn Asp Phe Asp Ile Glu Glu Ala Pro Asn Cys Ile Tyr 
                85                  90                  95      


Asp Ser Leu Ser Leu Asp Asn Gly Glu Ser Gln Thr Lys Phe Cys Gly 
            100                 105                 110         


Ala Thr Ala Lys Gly Leu Ser Phe Asn Ser Ser Ala Asn Glu Met His 
        115                 120                 125             


Val Ser Phe Ser Ser Asp Phe Ser Ile Gln Lys Lys Gly Phe Asn Ala 
    130                 135                 140                 


Ser Tyr Ile Arg Val Ala Val Ser Leu Arg Asn Gln Lys Val Ile Leu 
145                 150                 155                 160 


Pro Gln Thr Ser Asp Ala Tyr Gln Val Ser Val Ala Lys Ser Ile Ser 
                165                 170                 175     


Ile Pro Glu Leu Ser Ala Phe Thr Leu Cys Phe Glu Ala Thr Lys Val 
            180                 185                 190         


Gly His Glu Asp Ser Asp Trp Thr Ala Phe Ser Tyr Ser Asn Ala Ser 
        195                 200                 205             


Phe Thr Gln Leu Leu Ser Phe Gly Lys Ala Lys Ser Gly Tyr Phe Leu 
    210                 215                 220                 


Ser Ile Ser Asp Ser Lys Cys Leu Leu Asn Asn Ala Leu Pro Val Lys 
225                 230                 235                 240 


Glu Lys Glu Asp Ile Phe Ala Glu Ser Phe Glu Gln Leu Cys Leu Val 
                245                 250                 255     


Trp Asn Asn Ser Leu Gly Ser Ile Gly Val Asn Phe Lys Arg Asn Tyr 
            260                 265                 270         


Glu Thr Val Pro Cys Asp Ser Thr Ile Ser Lys Val Ile Pro Gly Asn 
        275                 280                 285             


Gly Lys Leu Leu Leu Gly Ser Asn Gln Asn Glu Ile Val Ser Leu Lys 
    290                 295                 300                 


Gly Asp Ile Tyr Asn Phe Arg Leu Trp Asn Phe Thr Met Asn Ala Lys 
305                 310                 315                 320 


Ile Leu Ser Asn Leu Ser Cys Asn Val Lys Gly Asn Val Val Asp Trp 
                325                 330                 335     


Gln Asn Asp Phe Trp Asn Ile Pro Asn Leu Ala Leu Lys Ala Glu Ser 
            340                 345                 350         


Asn Leu Ser Cys Gly Ser Tyr Leu Ile Pro Leu Pro Ala Ala Glu Leu 
        355                 360                 365             


Ala Ser Cys Ala Asp Leu Gly Thr Leu Cys Gln Asp Gly Ile Ile Tyr 
    370                 375                 380                 


Arg Ile Ser Val Val Ile Gln Asn Ile Leu Arg His Pro Glu Val Lys 
385                 390                 395                 400 


Val Gln Ser Lys Val Ala Glu Trp Leu Asn Ser Thr Phe Gln Asn Trp 
                405                 410                 415     


Asn Tyr Thr Val Tyr Val Val Asn Ile Ser Phe His Leu Ser Ala Gly 
            420                 425                 430         


Glu Asp Lys Ile Lys Val Lys Arg Ser Leu Glu Asp Glu Pro Arg Leu 
        435                 440                 445             


Val Leu Trp Ala Leu Leu Val Tyr Asn Ala Thr Asn Asn Thr Asn Leu 
    450                 455                 460                 


Glu Gly Lys Ile Ile Gln Gln Lys Leu Leu Lys Asn Asn Glu Ser Leu 
465                 470                 475                 480 


Asp Glu Gly Leu Arg Leu His Thr Val Asn Val Arg Gln Leu Gly His 
                485                 490                 495     


Cys Leu Ala Met Glu Glu Pro Lys Gly Tyr Tyr Trp Pro Ser Ile Gln 
            500                 505                 510         


Pro Ser Glu Tyr Val Leu Pro Cys Pro Asp Lys Pro Gly Phe Ser Ala 
        515                 520                 525             


Ser Arg Ile Cys Phe Tyr Asn Ala Thr Asn Pro Leu Val Thr Tyr Trp 
    530                 535                 540                 


Gly Pro Val Asp Ile Ser Asn Cys Leu Lys Glu Ala Asn Glu Val Ala 
545                 550                 555                 560 


Asn Gln Ile Leu Asn Leu Thr Ala Asp Gly Gln Asn Leu Thr Ser Ala 
                565                 570                 575     


Asn Ile Thr Asn Ile Val Glu Gln Val Lys Arg Ile Val Asn Lys Glu 
            580                 585                 590         


Glu Asn Ile Asp Ile Thr Leu Gly Ser Thr Leu Met Asn Ile Phe Ser 
        595                 600                 605             


Asn Ile Leu Ser Ser Ser Asp Ser Asp Leu Leu Glu Ser Ser Ser Glu 
    610                 615                 620                 


Ala Leu Lys Thr Ile Asp Glu Leu Ala Phe Lys Ile Asp Leu Asn Ser 
625                 630                 635                 640 


Thr Ser His Val Asn Ile Thr Thr Arg Asn Leu Ala Leu Ser Val Ser 
                645                 650                 655     


Ser Leu Leu Pro Gly Thr Asn Ala Ile Ser Asn Phe Ser Ile Gly Leu 
            660                 665                 670         


Pro Ser Asn Asn Glu Ser Tyr Phe Gln Met Asp Phe Glu Ser Gly Gln 
        675                 680                 685             


Val Asp Pro Leu Ala Ser Val Ile Leu Pro Pro Asn Leu Leu Glu Asn 
    690                 695                 700                 


Leu Ser Pro Glu Asp Ser Val Leu Val Arg Arg Ala Gln Phe Thr Phe 
705                 710                 715                 720 


Phe Asn Lys Thr Gly Leu Phe Gln Asp Val Gly Pro Gln Arg Lys Thr 
                725                 730                 735     


Leu Val Ser Tyr Val Met Ala Cys Ser Ile Gly Asn Ile Thr Ile Gln 
            740                 745                 750         


Asn Leu Lys Asp Pro Val Gln Ile Lys Ile Lys His Thr Arg Thr Gln 
        755                 760                 765             


Glu Val His His Pro Ile Cys Ala Phe Trp Asp Leu Asn Lys Asn Lys 
    770                 775                 780                 


Ser Phe Gly Gly Trp Asn Thr Ser Gly Cys Val Ala His Arg Asp Ser 
785                 790                 795                 800 


Asp Ala Ser Glu Thr Val Cys Leu Cys Asn His Phe Thr His Phe Gly 
                805                 810                 815     


Val Leu Met Asp Leu Pro Arg Ser Ala Ser Gln Leu Asp Ala Arg Asn 
            820                 825                 830         


Thr Lys Val Leu Thr Phe Ile Ser Tyr Ile Gly Cys Gly Ile Ser Ala 
        835                 840                 845             


Ile Phe Ser Ala Ala Thr Leu Leu Thr Tyr Val Ala Phe Glu Lys Leu 
    850                 855                 860                 


Arg Arg Asp Tyr Pro Ser Lys Ile Leu Met Asn Leu Ser Thr Ala Leu 
865                 870                 875                 880 


Leu Phe Leu Asn Leu Leu Phe Leu Leu Asp Gly Trp Ile Thr Ser Phe 
                885                 890                 895     


Asn Val Asp Gly Leu Cys Ile Ala Val Ala Val Leu Leu His Phe Phe 
            900                 905                 910         


Leu Leu Ala Thr Phe Thr Trp Met Gly Leu Glu Ala Ile His Met Tyr 
        915                 920                 925             


Ile Ala Leu Val Lys Val Phe Asn Thr Tyr Ile Arg Arg Tyr Ile Leu 
    930                 935                 940                 


Lys Phe Cys Ile Ile Gly Trp Gly Leu Pro Ala Leu Val Val Ser Val 
945                 950                 955                 960 


Val Leu Ala Ser Arg Asn Asn Asn Glu Val Tyr Gly Lys Glu Ser Tyr 
                965                 970                 975     


Gly Lys Glu Lys Gly Asp Glu Phe Cys Trp Ile Gln Asp Pro Val Ile 
            980                 985                 990         


Phe Tyr Val Thr Cys Ala Gly Tyr  Phe Gly Val Met Phe  Phe Leu Asn 
        995                 1000                 1005             


Ile Ala  Met Phe Ile Val Val  Met Val Gln Ile Cys  Gly Arg Asn 
    1010                 1015                 1020             


Gly Lys  Arg Ser Asn Arg Thr  Leu Arg Glu Glu Val  Leu Arg Asn 
    1025                 1030                 1035             


Leu Arg  Ser Val Val Ser Leu  Thr Phe Leu Leu Gly  Met Thr Trp 
    1040                 1045                 1050             


Gly Phe  Ala Phe Phe Ala Trp  Gly Pro Leu Asn Ile  Pro Phe Met 
    1055                 1060                 1065             


Tyr Leu  Phe Ser Ile Phe Asn  Ser Leu Gln Gly Leu  Phe Ile Phe 
    1070                 1075                 1080             


Ile Phe  His Cys Ala Met Lys  Glu Asn Val Gln Lys  Gln Trp Arg 
    1085                 1090                 1095             


Arg His  Leu Cys Cys Gly Arg  Phe Arg Leu Ala Asp  Asn Ser Asp 
    1100                 1105                 1110             


Trp Ser  Lys Thr Ala Thr Asn  Ile Ile Lys Lys Ser  Ser Asp Asn 
    1115                 1120                 1125             


Leu Gly  Lys Ser Leu Ser Ser  Ser Ser Ile Gly Ser  Asn Ser Thr 
    1130                 1135                 1140             


Tyr Leu  Thr Ser Lys Ser Lys  Ser Ser Ser Thr Thr  Tyr Phe Lys 
    1145                 1150                 1155             


Arg Asn  Ser His Thr Asp Ser  Ala Ser Met Asp Lys  Ser Leu Ser 
    1160                 1165                 1170             


Lys Leu  Ala His Ala Asp Gly  Asp Gln Thr Ser Ile  Ile Pro Val 
    1175                 1180                 1185             


His Gln  Val Ile Asp Lys Val  Lys Gly Tyr Cys Asn  Ala His Ser 
    1190                 1195                 1200             


Asp Asn  Phe Tyr Lys Asn Ile  Ile Met Ser Asp Thr  Phe Ser His 
    1205                 1210                 1215             


Ser Thr  Lys Phe 
    1220         


<210>  747
<211>  485
<212>  PRT
<213>  Homo sapiens

<400>  747

Met Ala Pro Arg Leu Gln Leu Glu Lys Ala Ala Trp Arg Trp Ala Glu 
1               5                   10                  15      


Thr Val Arg Pro Glu Glu Val Ser Gln Glu His Ile Glu Thr Ala Tyr 
            20                  25                  30          


Arg Ile Trp Leu Glu Pro Cys Ile Arg Gly Val Cys Arg Arg Asn Cys 
        35                  40                  45              


Lys Gly Asn Pro Asn Cys Leu Val Gly Ile Gly Glu His Ile Trp Leu 
    50                  55                  60                  


Gly Glu Ile Asp Glu Asn Ser Phe His Asn Ile Asp Asp Pro Asn Cys 
65                  70                  75                  80  


Glu Arg Arg Lys Lys Asn Ser Phe Val Gly Leu Thr Asn Leu Gly Ala 
                85                  90                  95      


Thr Cys Tyr Val Asn Thr Phe Leu Gln Val Trp Phe Leu Asn Leu Glu 
            100                 105                 110         


Leu Arg Gln Ala Leu Tyr Leu Cys Pro Ser Thr Cys Ser Asp Tyr Met 
        115                 120                 125             


Leu Gly Asp Gly Ile Gln Glu Glu Lys Asp Tyr Glu Pro Gln Thr Ile 
    130                 135                 140                 


Cys Glu His Leu Gln Tyr Leu Phe Ala Leu Leu Gln Asn Ser Asn Arg 
145                 150                 155                 160 


Arg Tyr Ile Asp Pro Ser Gly Phe Val Lys Ala Leu Gly Leu Asp Thr 
                165                 170                 175     


Gly Gln Gln Gln Asp Ala Gln Glu Phe Ser Lys Leu Phe Met Ser Leu 
            180                 185                 190         


Leu Glu Asp Thr Leu Ser Lys Gln Lys Asn Pro Asp Val Arg Asn Ile 
        195                 200                 205             


Val Gln Gln Gln Phe Cys Gly Glu Tyr Ala Tyr Val Thr Val Cys Asn 
    210                 215                 220                 


Gln Cys Gly Arg Glu Ser Lys Leu Leu Ser Lys Phe Tyr Glu Leu Glu 
225                 230                 235                 240 


Leu Asn Ile Gln Gly His Lys Gln Leu Thr Asp Cys Ile Ser Glu Phe 
                245                 250                 255     


Leu Lys Glu Glu Lys Leu Glu Gly Asp Asn Arg Tyr Phe Cys Glu Asn 
            260                 265                 270         


Cys Gln Ser Lys Gln Asn Ala Thr Arg Lys Ile Arg Leu Leu Ser Leu 
        275                 280                 285             


Pro Cys Thr Leu Asn Leu Gln Leu Met Arg Phe Val Phe Asp Arg Gln 
    290                 295                 300                 


Thr Gly His Lys Lys Lys Leu Asn Thr Tyr Ile Gly Phe Ser Glu Ile 
305                 310                 315                 320 


Leu Asp Met Glu Pro Tyr Val Glu His Lys Gly Gly Ser Tyr Val Tyr 
                325                 330                 335     


Glu Leu Ser Ala Val Leu Ile His Arg Gly Val Ser Ala Tyr Ser Gly 
            340                 345                 350         


His Tyr Ile Ala His Val Lys Asp Pro Gln Ser Gly Glu Trp Tyr Lys 
        355                 360                 365             


Phe Asn Asp Glu Asp Ile Glu Lys Met Glu Gly Lys Lys Leu Gln Leu 
    370                 375                 380                 


Gly Ile Glu Glu Asp Leu Ala Glu Pro Ser Lys Ser Gln Thr Arg Lys 
385                 390                 395                 400 


Pro Lys Cys Gly Lys Gly Thr His Cys Ser Arg Asn Ala Tyr Met Leu 
                405                 410                 415     


Val Tyr Arg Leu Gln Thr Gln Glu Lys Pro Asn Thr Thr Val Gln Val 
            420                 425                 430         


Pro Ala Phe Leu Gln Glu Leu Val Asp Arg Asp Asn Ser Lys Phe Glu 
        435                 440                 445             


Glu Trp Cys Ile Glu Met Ala Glu Met Arg Lys Gln Ser Val Asp Lys 
    450                 455                 460                 


Gly Lys Ala Lys His Glu Glu Val Lys Glu Leu Tyr Gln Arg Leu Pro 
465                 470                 475                 480 


Ala Gly Ala Gly Leu 
                485 


<210>  748
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  748

Met Gly Arg Leu Leu Ala Leu Val Val Gly Ala Ala Leu Val Ser Ser 
1               5                   10                  15      


Ala Cys Gly Gly Cys Val Glu Val Asp Ser Glu Thr Glu Ala Val Tyr 
            20                  25                  30          


Gly Met Thr Phe Lys Ile Leu Cys Ile Ser Cys Lys Arg Arg Ser Glu 
        35                  40                  45              


Thr Asn Ala Glu Thr Phe Thr Glu Trp Thr Phe Arg Gln Lys Gly Thr 
    50                  55                  60                  


Glu Glu Phe Val Lys Ile Leu Arg Tyr Glu Asn Glu Val Leu Gln Leu 
65                  70                  75                  80  


Glu Glu Asp Glu Arg Phe Glu Gly Arg Val Val Trp Asn Gly Ser Arg 
                85                  90                  95      


Gly Thr Lys Asp Leu Gln Asp Leu Ser Ile Phe Ile Thr Asn Val Thr 
            100                 105                 110         


Tyr Asn His Ser Gly Asp Tyr Glu Cys His Val Tyr Arg Leu Leu Phe 
        115                 120                 125             


Phe Glu Asn Tyr Glu His Asn Thr Ser Val Val Lys Lys Ile His Ile 
    130                 135                 140                 


Glu Val Val Asp Lys Ala Asn Arg Asp Met Ala Ser Ile Val Ser Glu 
145                 150                 155                 160 


Ile Met Met Tyr Val Leu Ile Val Val Leu Thr Ile Trp Leu Val Ala 
                165                 170                 175     


Glu Met Ile Tyr Cys Tyr Lys Lys Ile Ala Ala Ala Thr Glu Thr Ala 
            180                 185                 190         


Ala Gln Glu Asn Ala Ser Glu Tyr Leu Ala Ile Thr Ser Glu Ser Lys 
        195                 200                 205             


Glu Asn Cys Thr Gly Val Gln Val Ala Glu 
    210                 215             


<210>  749
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  749

Met Arg Cys Cys His Ile Cys Lys Leu Pro Gly Arg Val Met Gly Ile 
1               5                   10                  15      


Arg Val Leu Arg Leu Ser Leu Val Val Ile Leu Val Leu Leu Leu Val 
            20                  25                  30          


Ala Gly Ala Leu Thr Ala Leu Leu Pro Ser Val Lys Glu Asp Lys Met 
        35                  40                  45              


Leu Met Leu Arg Arg Glu Ile Lys Ser Gln Gly Lys Ser Thr Met Asp 
    50                  55                  60                  


Ser Phe Thr Leu Ile Met Gln Thr Tyr Asn Arg Thr Asp Leu Leu Leu 
65                  70                  75                  80  


Lys Leu Leu Asn His Tyr Gln Ala Val Pro Asn Leu His Lys Val Ile 
                85                  90                  95      


Val Val Trp Asn Asn Ile Gly Glu Lys Ala Pro Asp Glu Leu Trp Asn 
            100                 105                 110         


Ser Leu Gly Pro His Pro Ile Pro Val Ile Phe Lys Gln Gln Thr Ala 
        115                 120                 125             


Asn Arg Met Arg Asn Arg Leu Gln Val Phe Pro Glu Leu Glu Thr Asn 
    130                 135                 140                 


Ala Val Leu Met Val Asp Asp Asp Thr Leu Ile Ser Thr Pro Asp Leu 
145                 150                 155                 160 


Val Phe Ala Phe Ser Val Trp Gln Gln Phe Pro Asp Gln Ile Val Gly 
                165                 170                 175     


Phe Val Pro Arg Lys His Val Ser Thr Ser Ser Gly Ile Tyr Ser Tyr 
            180                 185                 190         


Gly Ser Phe Glu Met Gln Ala Pro Gly Ser Gly Asn Gly Asp Gln Tyr 
        195                 200                 205             


Ser Met Val Leu Ile Gly Ala Ser Phe Phe Asn Ser Lys Tyr Leu Glu 
    210                 215                 220                 


Leu Phe Gln Arg Gln Pro Ala Ala Val His Ala Leu Ile Asp Asp Thr 
225                 230                 235                 240 


Gln Asn Cys Asp Asp Ile Ala Met Asn Phe Ile Ile Ala Lys His Ile 
                245                 250                 255     


Gly Lys Thr Ser Gly Ile Phe Val Lys Pro Val Asn Met Asp Asn Leu 
            260                 265                 270         


Glu Lys Glu Thr Asn Ser Gly Tyr Ser Gly Met Trp His Arg Ala Glu 
        275                 280                 285             


His Ala Leu Gln Arg Ser Tyr Cys Ile Asn Lys Leu Val Asn Ile Tyr 
    290                 295                 300                 


Asp Ser Met Pro Leu Arg Tyr Ser Asn Ile Met Ile Ser Gln Phe Gly 
305                 310                 315                 320 


Phe Pro Tyr Ala Asn Tyr Lys Arg Lys Ile 
                325                 330 


<210>  750
<211>  620
<212>  PRT
<213>  Homo sapiens

<400>  750

Met Ser Glu His Val Glu Pro Ala Ala Pro Gly Pro Gly Pro Asn Gly 
1               5                   10                  15      


Gly Gly Gly Gly Pro Ala Pro Ala Arg Gly Pro Arg Thr Pro Asn Leu 
            20                  25                  30          


Asn Pro Asn Pro Leu Ile Asn Val Arg Asp Arg Leu Phe His Ala Leu 
        35                  40                  45              


Phe Phe Lys Met Ala Val Thr Tyr Ser Arg Leu Phe Pro Pro Ala Phe 
    50                  55                  60                  


Arg Arg Leu Phe Glu Phe Phe Val Leu Leu Lys Ala Leu Phe Val Leu 
65                  70                  75                  80  


Phe Val Leu Ala Tyr Ile His Ile Val Phe Ser Arg Ser Pro Ile Asn 
                85                  90                  95      


Cys Leu Glu His Val Arg Asp Lys Trp Pro Arg Glu Gly Ile Leu Arg 
            100                 105                 110         


Val Glu Val Arg His Asn Ser Ser Arg Ala Pro Val Phe Leu Gln Phe 
        115                 120                 125             


Cys Asp Ser Gly Gly Arg Gly Ser Phe Pro Gly Leu Ala Val Glu Pro 
    130                 135                 140                 


Gly Ser Asn Leu Asp Met Glu Asp Glu Glu Glu Glu Glu Leu Thr Met 
145                 150                 155                 160 


Glu Met Phe Gly Asn Ser Ser Ile Lys Phe Glu Leu Asp Ile Glu Pro 
                165                 170                 175     


Lys Val Phe Lys Pro Pro Ser Ser Thr Glu Ala Leu Asn Asp Ser Gln 
            180                 185                 190         


Glu Phe Pro Phe Pro Glu Thr Pro Thr Lys Val Trp Pro Gln Asp Glu 
        195                 200                 205             


Tyr Ile Val Glu Tyr Ser Leu Glu Tyr Gly Phe Leu Arg Leu Ser Gln 
    210                 215                 220                 


Ala Thr Arg Gln Arg Leu Ser Ile Pro Val Met Val Val Thr Leu Asp 
225                 230                 235                 240 


Pro Thr Arg Asp Gln Cys Phe Gly Asp Arg Phe Ser Arg Leu Leu Leu 
                245                 250                 255     


Asp Glu Phe Leu Gly Tyr Asp Asp Ile Leu Met Ser Ser Val Lys Gly 
            260                 265                 270         


Leu Ala Glu Asn Glu Glu Asn Lys Gly Phe Leu Arg Asn Val Val Ser 
        275                 280                 285             


Gly Glu His Tyr Arg Phe Val Ser Met Trp Met Ala Arg Thr Ser Tyr 
    290                 295                 300                 


Leu Ala Ala Phe Ala Ile Met Val Ile Phe Thr Leu Ser Val Ser Met 
305                 310                 315                 320 


Leu Leu Arg Tyr Ser His His Gln Ile Phe Val Phe Ile Val Asp Leu 
                325                 330                 335     


Leu Gln Met Leu Glu Met Asn Met Ala Ile Ala Phe Pro Ala Ala Pro 
            340                 345                 350         


Leu Leu Thr Val Ile Leu Ala Leu Val Gly Met Glu Ala Ile Met Ser 
        355                 360                 365             


Glu Phe Phe Asn Asp Thr Thr Thr Ala Phe Tyr Ile Ile Leu Ile Val 
    370                 375                 380                 


Trp Leu Ala Asp Gln Tyr Asp Ala Ile Cys Cys His Thr Ser Thr Ser 
385                 390                 395                 400 


Lys Arg His Trp Leu Arg Phe Phe Tyr Leu Tyr His Phe Ala Phe Tyr 
                405                 410                 415     


Ala Tyr His Tyr Arg Phe Asn Gly Gln Tyr Ser Ser Leu Ala Leu Val 
            420                 425                 430         


Thr Ser Trp Leu Phe Ile Gln His Ser Met Ile Tyr Phe Phe His His 
        435                 440                 445             


Tyr Glu Leu Pro Ala Ile Leu Gln Gln Val Arg Ile Gln Glu Met Leu 
    450                 455                 460                 


Leu Gln Ala Pro Pro Leu Gly Pro Gly Thr Pro Thr Ala Leu Pro Asp 
465                 470                 475                 480 


Asp Met Asn Asn Asn Ser Gly Ala Pro Ala Thr Ala Pro Asp Ser Ala 
                485                 490                 495     


Gly Gln Pro Pro Ala Leu Gly Pro Val Ser Pro Gly Ala Ser Gly Ser 
            500                 505                 510         


Pro Gly Pro Val Ala Ala Ala Pro Ser Ser Leu Val Ala Ala Ala Ala 
        515                 520                 525             


Ser Val Ala Ala Ala Ala Gly Gly Asp Leu Gly Trp Met Ala Glu Thr 
    530                 535                 540                 


Ala Ala Ile Ile Thr Asp Ala Ser Phe Leu Ser Gly Leu Ser Ala Ser 
545                 550                 555                 560 


Leu Leu Glu Arg Arg Pro Ala Ser Pro Leu Gly Pro Ala Gly Gly Leu 
                565                 570                 575     


Pro His Ala Pro Gln Asp Ser Val Pro Pro Ser Asp Ser Ala Ala Ser 
            580                 585                 590         


Asp Thr Thr Pro Leu Gly Ala Ala Val Gly Gly Pro Ser Pro Ala Ser 
        595                 600                 605             


Met Ala Pro Thr Glu Ala Pro Ser Glu Val Gly Ser 
    610                 615                 620 


<210>  751
<211>  870
<212>  PRT
<213>  Homo sapiens

<400>  751

Met Asn Ser Asn Leu Pro Ala Glu Asn Leu Thr Ile Ala Val Asn Met 
1               5                   10                  15      


Thr Lys Thr Leu Pro Thr Ala Val Thr His Gly Phe Asn Ser Thr Asn 
            20                  25                  30          


Asp Pro Pro Ser Met Ser Ile Thr Arg Leu Phe Pro Ala Leu Leu Glu 
        35                  40                  45              


Cys Phe Gly Ile Val Leu Cys Gly Tyr Ile Ala Gly Arg Ala Asn Val 
    50                  55                  60                  


Ile Thr Ser Thr Gln Ala Lys Gly Leu Gly Asn Phe Val Ser Arg Phe 
65                  70                  75                  80  


Ala Leu Pro Ala Leu Leu Phe Lys Asn Met Val Val Leu Asn Phe Ser 
                85                  90                  95      


Asn Val Asp Trp Ser Phe Leu Tyr Ser Ile Leu Ile Ala Lys Ala Ser 
            100                 105                 110         


Val Phe Phe Ile Val Cys Val Leu Thr Leu Leu Val Ala Ser Pro Asp 
        115                 120                 125             


Ser Arg Phe Ser Lys Ala Gly Leu Phe Pro Ile Phe Ala Thr Gln Ser 
    130                 135                 140                 


Asn Asp Phe Ala Leu Gly Tyr Pro Ile Val Glu Ala Leu Tyr Gln Thr 
145                 150                 155                 160 


Thr Tyr Pro Glu Tyr Leu Gln Tyr Ile Tyr Leu Val Ala Pro Ile Ser 
                165                 170                 175     


Leu Met Met Leu Asn Pro Ile Gly Phe Ile Phe Cys Glu Ile Gln Lys 
            180                 185                 190         


Trp Lys Asp Thr Gln Asn Ala Ser Gln Asn Lys Ile Lys Ile Val Gly 
        195                 200                 205             


Leu Gly Leu Leu Arg Val Leu Gln Asn Pro Ile Val Phe Met Val Phe 
    210                 215                 220                 


Ile Gly Ile Ala Phe Asn Phe Ile Leu Asp Arg Lys Val Pro Val Tyr 
225                 230                 235                 240 


Val Glu Asn Phe Leu Asp Gly Leu Gly Asn Ser Phe Ser Gly Ser Ala 
                245                 250                 255     


Leu Phe Tyr Leu Gly Leu Thr Met Val Gly Lys Ile Lys Arg Leu Lys 
            260                 265                 270         


Lys Ser Ala Phe Val Val Leu Ile Leu Leu Ile Thr Ala Lys Leu Leu 
        275                 280                 285             


Val Leu Pro Leu Leu Cys Arg Glu Met Val Glu Leu Leu Asp Lys Gly 
    290                 295                 300                 


Asp Ser Val Val Asn His Thr Ser Leu Ser Asn Tyr Ala Phe Leu Tyr 
305                 310                 315                 320 


Gly Val Phe Pro Val Ala Pro Gly Val Ala Ile Phe Ala Thr Gln Phe 
                325                 330                 335     


Asn Met Glu Val Glu Ile Ile Thr Ser Gly Met Val Ile Ser Thr Phe 
            340                 345                 350         


Val Ser Ala Pro Ile Met Tyr Val Ser Ala Trp Leu Leu Thr Phe Pro 
        355                 360                 365             


Thr Met Asp Pro Lys Pro Leu Ala Tyr Ala Ile Gln Asn Val Ser Phe 
    370                 375                 380                 


Asp Ile Ser Ile Val Ser Leu Ile Ser Leu Ile Trp Ser Leu Ala Ile 
385                 390                 395                 400 


Leu Leu Leu Ser Lys Lys Tyr Lys Gln Leu Pro His Met Leu Thr Thr 
                405                 410                 415     


Asn Leu Leu Ile Ala Gln Ser Ile Val Cys Ala Gly Met Met Ile Trp 
            420                 425                 430         


Asn Phe Val Lys Glu Lys Asn Phe Val Gly Gln Ile Leu Val Phe Val 
        435                 440                 445             


Leu Leu Tyr Ser Ser Leu Tyr Ser Thr Tyr Leu Trp Thr Gly Leu Leu 
    450                 455                 460                 


Ala Ile Ser Leu Phe Leu Leu Lys Lys Arg Glu Arg Val Gln Ile Pro 
465                 470                 475                 480 


Val Gly Ile Ile Ile Ile Ser Gly Trp Gly Ile Pro Ala Leu Leu Val 
                485                 490                 495     


Gly Val Leu Leu Ile Thr Gly Lys His Asn Gly Asp Ser Ile Asp Ser 
            500                 505                 510         


Ala Phe Phe Tyr Gly Lys Glu Gln Met Ile Thr Thr Ala Val Thr Leu 
        515                 520                 525             


Phe Cys Ser Ile Leu Ile Ala Gly Ile Ser Leu Met Cys Met Asn Gln 
    530                 535                 540                 


Thr Ala Gln Ala Gly Ser Tyr Glu Gly Phe Asp Gln Ser Gln Ser His 
545                 550                 555                 560 


Lys Val Val Glu Pro Gly Asn Thr Ala Phe Glu Glu Ser Pro Ala Pro 
                565                 570                 575     


Val Asn Glu Pro Glu Leu Phe Thr Ser Ser Ile Pro Glu Thr Ser Cys 
            580                 585                 590         


Cys Ser Cys Ser Met Gly Asn Gly Glu Leu His Cys Pro Ser Ile Glu 
        595                 600                 605             


Pro Ile Ala Asn Thr Ser Thr Ser Glu Pro Val Ile Pro Ser Phe Glu 
    610                 615                 620                 


Lys Asn Asn His Cys Val Ser Arg Cys Asn Ser Gln Ser Cys Ile Leu 
625                 630                 635                 640 


Ala Gln Glu Glu Glu Gln Tyr Leu Gln Ser Gly Asp Gln Gln Leu Thr 
                645                 650                 655     


Arg His Val Leu Leu Cys Leu Leu Leu Ile Ile Gly Leu Phe Ala Asn 
            660                 665                 670         


Leu Ser Ser Cys Leu Trp Trp Leu Phe Asn Gln Glu Pro Gly Arg Leu 
        675                 680                 685             


Tyr Val Glu Leu Gln Phe Phe Cys Ala Val Phe Asn Phe Gly Gln Gly 
    690                 695                 700                 


Phe Ile Ser Phe Gly Ile Phe Gly Leu Asp Lys His Leu Ile Ile Leu 
705                 710                 715                 720 


Pro Phe Lys Arg Arg Leu Glu Phe Leu Trp Asn Asn Lys Asp Thr Ala 
                725                 730                 735     


Glu Asn Arg Asp Ser Pro Val Ser Glu Glu Ile Lys Met Thr Cys Gln 
            740                 745                 750         


Gln Phe Ile His Tyr His Arg Asp Leu Cys Ile Arg Asn Ile Val Lys 
        755                 760                 765             


Glu Arg Arg Cys Gly Ala Lys Thr Ser Ala Gly Thr Phe Cys Gly Cys 
    770                 775                 780                 


Asp Leu Val Ser Trp Leu Ile Glu Val Gly Leu Ala Ser Asp Arg Gly 
785                 790                 795                 800 


Glu Ala Val Ile Tyr Gly Asp Arg Leu Val Gln Gly Gly Val Ile Gln 
                805                 810                 815     


His Ile Thr Asn Glu Tyr Glu Phe Arg Asp Glu Tyr Leu Phe Tyr Arg 
            820                 825                 830         


Phe Leu Gln Lys Ser Pro Glu Gln Ser Pro Pro Ala Ile Asn Ala Asn 
        835                 840                 845             


Thr Leu Gln Gln Glu Arg Tyr Lys Glu Ile Glu His Ser Ser Pro Pro 
    850                 855                 860                 


Ser His Ser Pro Lys Thr 
865                 870 


<210>  752
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  752

Met Tyr Leu Gln Val Glu Thr Arg Thr Ser Ser Arg Leu His Leu Lys 
1               5                   10                  15      


Arg Ala Pro Gly Ile Arg Ser Trp Ser Leu Leu Val Gly Ile Leu Ser 
            20                  25                  30          


Ile Gly Leu Ala Ala Ala Tyr Tyr Ser Gly Asp Ser Leu Gly Trp Lys 
        35                  40                  45              


Leu Phe Tyr Val Thr Gly Cys Leu Phe Val Ala Val Gln Asn Leu Glu 
    50                  55                  60                  


Asp Trp Glu Glu Ala Ile Phe Asp Lys Ser Thr Gly Lys Val Val Leu 
65                  70                  75                  80  


Lys Thr Phe Ser Leu Tyr Lys Lys Leu Leu Thr Leu Phe Arg Ala Gly 
                85                  90                  95      


His Asp Gln Val Val Val Leu Leu His Asp Val Arg Asp Val Ser Val 
            100                 105                 110         


Glu Glu Glu Lys Val Arg Tyr Phe Gly Lys Gly Tyr Met Val Val Leu 
        115                 120                 125             


Arg Leu Ala Thr Gly Phe Ser His Pro Leu Thr Gln Ser Ala Val Met 
    130                 135                 140                 


Gly His Arg Ser Asp Val Glu Ala Ile Ala Lys Leu Ile Thr Ser Phe 
145                 150                 155                 160 


Leu Glu Leu His Cys Leu Glu Ser Pro Thr Glu Leu Ser Gln Ser Ser 
                165                 170                 175     


Asp Ser Glu Ala Gly Asp Pro Ala Ser Gln Ser 
            180                 185         


<210>  753
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  753

Met Ala Val Ser Ser Glu Gln His Glu Leu Ser His Phe Lys Arg Thr 
1               5                   10                  15      


Gln Thr Lys Lys Glu Lys Phe Asn Cys Ser Glu Tyr Gly Asn Arg Ser 
            20                  25                  30          


Cys Pro Glu Asn Glu Arg Ser Leu Gly Val Arg Val Ala Met Tyr Ser 
        35                  40                  45              


Phe Met Ala Gly Ser Ile Phe Ile Thr Ile Phe Gly Asn Leu Ala Met 
    50                  55                  60                  


Ile Ile Ser Ile Ser Tyr Phe Lys Gln Leu His Thr Pro Thr Asn Phe 
65                  70                  75                  80  


Leu Ile Leu Ser Met Ala Ile Thr Asp Phe Leu Leu Gly Phe Thr Ile 
                85                  90                  95      


Met Pro Tyr Ser Met Ile Arg Ser Val Glu Asn Cys Trp Tyr Phe Gly 
            100                 105                 110         


Leu Thr Phe Cys Lys Ile Tyr Tyr Ser Phe Asp Leu Met Leu Ser Ile 
        115                 120                 125             


Thr Ser Ile Phe His Leu Cys Ser Val Ala Ile Asp Arg Phe Tyr Ala 
    130                 135                 140                 


Ile Cys Tyr Pro Leu Leu Tyr Ser Thr Lys Ile Thr Ile Pro Val Ile 
145                 150                 155                 160 


Lys Arg Leu Leu Leu Leu Cys Trp Ser Val Pro Gly Ala Phe Ala Phe 
                165                 170                 175     


Gly Val Val Phe Ser Glu Ala Tyr Ala Asp Gly Ile Glu Gly Tyr Asp 
            180                 185                 190         


Ile Leu Val Ala Cys Ser Ser Ser Cys Pro Val Met Phe Asn Lys Leu 
        195                 200                 205             


Trp Gly Thr Thr Leu Phe Met Ala Gly Phe Phe Thr Pro Gly Ser Met 
    210                 215                 220                 


Met Val Gly Ile Tyr Gly Lys Ile Phe Ala Val Ser Arg Lys His Ala 
225                 230                 235                 240 


His Ala Ile Asn Asn Leu Arg Glu Asn Gln Asn Asn Gln Val Lys Lys 
                245                 250                 255     


Asp Lys Lys Ala Ala Lys Thr Leu Gly Ile Val Ile Gly Val Phe Leu 
            260                 265                 270         


Leu Cys Trp Phe Pro Cys Phe Phe Thr Ile Leu Leu Asp Pro Phe Leu 
        275                 280                 285             


Asn Phe Ser Thr Pro Val Val Leu Phe Asp Ala Leu Thr Trp Phe Gly 
    290                 295                 300                 


Tyr Phe Asn Ser Thr Cys Asn Pro Leu Ile Tyr Gly Phe Phe Tyr Pro 
305                 310                 315                 320 


Trp Phe Arg Arg Ala Leu Lys Tyr Ile Leu Leu Gly Lys Ile Phe Ser 
                325                 330                 335     


Ser Cys Phe His Asn Thr Ile Leu Cys Met Gln Lys Glu Ser Glu 
            340                 345                 350     


<210>  754
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  754

Met Glu Thr Val Val Ile Val Ala Ile Gly Val Leu Ala Thr Ile Phe 
1               5                   10                  15      


Leu Ala Ser Phe Ala Ala Leu Val Leu Val Cys Arg Gln Arg Tyr Cys 
            20                  25                  30          


Arg Pro Arg Asp Leu Leu Gln Arg Tyr Asp Ser Lys Pro Ile Val Asp 
        35                  40                  45              


Leu Ile Gly Ala Met Glu Thr Gln Ser Glu Pro Ser Glu Leu Glu Leu 
    50                  55                  60                  


Asp Asp Val Val Ile Thr Asn Pro His Ile Glu Ala Ile Leu Glu Asn 
65                  70                  75                  80  


Glu Asp Trp Ile Glu Asp Ala Ser Gly Leu Met Ser His Cys Ile Ala 
                85                  90                  95      


Ile Leu Lys Ile Cys His Thr Leu Thr Glu Lys Leu Val Ala Met Thr 
            100                 105                 110         


Met Gly Ser Gly Ala Lys Met Lys Thr Ser Ala Ser Val Ser Asp Ile 
        115                 120                 125             


Ile Val Val Ala Lys Arg Ile Ser Pro Arg Val Asp Asp Val Val Lys 
    130                 135                 140                 


Ser Met Tyr Pro Pro Leu Asp Pro Lys Leu Leu Asp Ala Arg Thr Thr 
145                 150                 155                 160 


Ala Leu Leu Leu Ser Val Ser His Leu Val Leu Val Thr Arg Asn Ala 
                165                 170                 175     


Cys His Leu Thr Gly Gly Leu Asp Trp Ile Asp Gln Ser Leu Ser Ala 
            180                 185                 190         


Ala Glu Glu His Leu Glu Val Leu Arg Glu Ala Ala Leu Ala Ser Glu 
        195                 200                 205             


Pro Asp Lys Gly Leu Pro Gly Pro Glu Gly Phe Leu Gln Glu Gln Ser 
    210                 215                 220                 


Ala Ile 
225     


<210>  755
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  755

Met Val Ala Pro Lys Ser His Thr Asp Asp Trp Ala Pro Gly Pro Phe 
1               5                   10                  15      


Ser Ser Lys Pro Gln Arg Ser Gln Leu Gln Ile Phe Ser Ser Val Leu 
            20                  25                  30          


Gln Thr Ser Leu Leu Phe Leu Leu Met Gly Leu Arg Ala Ser Gly Lys 
        35                  40                  45              


Asp Ser Ala Pro Thr Val Val Ser Gly Ile Leu Gly Gly Ser Val Thr 
    50                  55                  60                  


Leu Pro Leu Asn Ile Ser Val Asp Thr Glu Ile Glu Asn Val Ile Trp 
65                  70                  75                  80  


Ile Gly Pro Lys Asn Ala Leu Ala Phe Ala Arg Pro Lys Glu Asn Val 
                85                  90                  95      


Thr Ile Met Val Lys Ser Tyr Leu Gly Arg Leu Asp Ile Thr Lys Trp 
            100                 105                 110         


Ser Tyr Ser Leu Cys Ile Ser Asn Leu Thr Leu Asn Asp Ala Gly Ser 
        115                 120                 125             


Tyr Lys Ala Gln Ile Asn Gln Arg Asn Phe Glu Val Thr Thr Glu Glu 
    130                 135                 140                 


Glu Phe Thr Leu Phe Val Tyr Ala Pro Phe Ile Glu Lys Leu Ser Val 
145                 150                 155                 160 


His Val Ile Glu Gly Asp His Arg Thr Leu Leu Glu Gly Ser Gly Leu 
                165                 170                 175     


Glu Ser Ile Ile Ser Thr Leu Ala Glu Pro Arg Val Ser Val Arg Glu 
            180                 185                 190         


Gly 
    


<210>  756
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  756

Met Glu Gly Asn Lys Leu Glu Glu Gln Asp Ser Ser Pro Pro Gln Ser 
1               5                   10                  15      


Thr Pro Gly Leu Met Lys Gly Asn Lys Arg Glu Glu Gln Gly Leu Gly 
            20                  25                  30          


Pro Glu Pro Ala Ala Pro Gln Gln Pro Thr Ala Glu Glu Glu Ala Leu 
        35                  40                  45              


Ile Glu Phe His Arg Ser Tyr Arg Glu Leu Phe Glu Phe Phe Cys Asn 
    50                  55                  60                  


Asn Thr Thr Ile His Gly Ala Ile Arg Leu Val Cys Ser Gln His Asn 
65                  70                  75                  80  


Arg Met Lys Thr Ala Phe Trp Ala Val Leu Trp Leu Cys Thr Phe Gly 
                85                  90                  95      


Met Met Tyr Trp Gln Phe Gly Leu Leu Phe Gly Glu Tyr Phe Ser Tyr 
            100                 105                 110         


Pro Val Ser Leu Asn Ile Asn Leu Asn Ser Asp Lys Leu Val Phe Pro 
        115                 120                 125             


Ala Val Thr Ile Cys Thr Leu Asn Pro Tyr Arg Tyr Pro Glu Ile Lys 
    130                 135                 140                 


Glu Glu Leu Glu Glu Leu Asp Arg Ile Thr Glu Gln Thr Leu Phe Asp 
145                 150                 155                 160 


Leu Tyr Lys Tyr Ser Ser Phe Thr Thr Leu Val Ala Gly Ser Arg Ser 
                165                 170                 175     


Arg Arg Asp Leu Arg Gly Thr Leu Pro His Pro Leu Gln Arg Leu Arg 
            180                 185                 190         


Val Pro Pro Pro Pro His Gly Ala Arg Arg Ala Arg Ser Val Ala Ser 
        195                 200                 205             


Ser Leu Arg Asp Asn Asn Pro Gln Val Asp Trp Lys Asp Trp Lys Ile 
    210                 215                 220                 


Gly Phe Gln Leu Cys Asn Gln Asn Lys Ser Asp Cys Phe Tyr Gln Thr 
225                 230                 235                 240 


Tyr Ser Ser Gly Val Asp Ala Val Arg Glu Trp Tyr Arg Phe His Tyr 
                245                 250                 255     


Ile Asn Ile Leu Ser Arg Leu Pro Glu Thr Leu Pro Ser Leu Glu Glu 
            260                 265                 270         


Asp Thr Leu Gly Asn Phe Ile Phe Ala Cys Arg Phe Asn Gln Val Ser 
        275                 280                 285             


Cys Asn Gln Ala Asn Tyr Ser His Phe His His Pro Met Tyr Gly Asn 
    290                 295                 300                 


Cys Tyr Thr Phe Asn Asp Lys Asn Asn Ser Asn Leu Trp Met Ser Ser 
305                 310                 315                 320 


Met Pro Gly Ile Asn Asn Gly Leu Ser Leu Met Leu Arg Ala Glu Gln 
                325                 330                 335     


Asn Asp Phe Ile Pro Leu Leu Ser Thr Val Thr Gly Ala Arg Val Met 
            340                 345                 350         


Val His Gly Gln Asp Glu Pro Ala Phe Met Asp Asp Gly Gly Phe Asn 
        355                 360                 365             


Leu Arg Pro Gly Val Glu Thr Ser Ile Ser Met Arg Lys Glu Thr Leu 
    370                 375                 380                 


Asp Arg Leu Gly Gly Asp Tyr Gly Asp Cys Thr Lys Asn Gly Ser Asp 
385                 390                 395                 400 


Val Pro Val Glu Asn Leu Tyr Pro Ser Lys Tyr Thr Gln Gln Val Cys 
                405                 410                 415     


Ile His Ser Cys Phe Gln Glu Ser Met Ile Lys Glu Cys Gly Cys Ala 
            420                 425                 430         


Tyr Ile Phe Tyr Pro Arg Pro Gln Asn Val Glu Tyr Cys Asp Tyr Arg 
        435                 440                 445             


Lys His Ser Ser Trp Gly Tyr Cys Tyr Tyr Lys Leu Gln Val Asp Phe 
    450                 455                 460                 


Ser Ser Asp His Leu Gly Cys Phe Thr Lys Cys Arg Lys Pro Cys Ser 
465                 470                 475                 480 


Val Thr Ser Tyr Gln Leu Ser Ala Gly Tyr Ser Arg Trp Pro Ser Val 
                485                 490                 495     


Thr Ser Gln Glu Trp Val Phe Gln Met Leu Ser Arg Gln Asn Asn Tyr 
            500                 505                 510         


Thr Val Asn Asn Lys Arg Asn Gly Val Ala Lys Val Asn Ile Phe Phe 
        515                 520                 525             


Lys Glu Leu Asn Tyr Lys Thr Asn Ser Glu Ser Pro Ser Val Thr Met 
    530                 535                 540                 


Val Thr Leu Leu Ser Asn Leu Gly Ser Gln Trp Ser Leu Trp Phe Gly 
545                 550                 555                 560 


Ser Ser Val Leu Ser Val Val Glu Met Ala Glu Leu Val Phe Asp Leu 
                565                 570                 575     


Leu Val Ile Met Phe Leu Met Leu Leu Arg Arg Phe Arg Ser Arg Tyr 
            580                 585                 590         


Trp Ser Pro Gly Arg Gly Gly Arg Gly Ala Gln Glu Val Ala Ser Thr 
        595                 600                 605             


Leu Ala Ser Ser Pro Pro Ser His Phe Cys Pro His Pro Met Ser Leu 
    610                 615                 620                 


Ser Leu Ser Gln Pro Gly Pro Ala Pro Ser Pro Ala Leu Thr Ala Pro 
625                 630                 635                 640 


Pro Pro Ala Tyr Ala Thr Leu Gly Pro Arg Pro Ser Pro Gly Gly Ser 
                645                 650                 655     


Ala Gly Ala Ser Ser Ser Thr Cys Pro Leu Gly Gly Pro 
            660                 665                 


<210>  757
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  757

Met Thr Ser Leu Leu Thr Thr Pro Ser Pro Arg Glu Glu Leu Met Thr 
1               5                   10                  15      


Thr Pro Ile Leu Gln Pro Thr Glu Ala Leu Ser Pro Glu Asp Gly Ala 
            20                  25                  30          


Ser Thr Ala Leu Ile Ala Val Val Ile Thr Val Val Phe Leu Thr Leu 
        35                  40                  45              


Leu Ser Val Val Ile Leu Ile Phe Phe Tyr Leu Tyr Lys Asn Lys Gly 
    50                  55                  60                  


Ser Tyr Val Thr Tyr Glu Pro Thr Glu Gly Glu Pro Ser Ala Ile Val 
65                  70                  75                  80  


Gln Met Glu Ser Asp Leu Ala Lys Gly Ser Glu Lys Glu Glu Tyr Phe 
                85                  90                  95      


Ile 
    


<210>  758
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  758

Met Ala Ala Ala Val Pro Arg Ala Ala Phe Leu Ser Pro Leu Leu Pro 
1               5                   10                  15      


Leu Leu Leu Gly Phe Leu Leu Leu Ser Ala Pro His Gly Gly Ser Gly 
            20                  25                  30          


Leu His Thr Lys Gly Ala Leu Pro Leu Asp Thr Val Thr Phe Tyr Lys 
        35                  40                  45              


Ile Met Val Thr Ser 
    50              


<210>  759
<211>  649
<212>  PRT
<213>  Homo sapiens

<400>  759

Met Ala Pro Gly Glu Lys Ile Lys Ala Lys Ile Lys Lys Asn Leu Pro 
1               5                   10                  15      


Val Thr Gly Pro Gln Ala Pro Thr Ile Lys Glu Leu Met Arg Trp Tyr 
            20                  25                  30          


Cys Leu Asn Thr Asn Thr His Gly Cys Arg Arg Ile Val Val Ser Arg 
        35                  40                  45              


Gly Arg Leu Arg Arg Leu Leu Trp Ile Gly Phe Thr Leu Thr Ala Val 
    50                  55                  60                  


Ala Leu Ile Leu Trp Gln Cys Ala Leu Leu Val Phe Ser Phe Tyr Thr 
65                  70                  75                  80  


Val Ser Val Ser Ile Lys Val His Phe Arg Lys Leu Asp Phe Pro Ala 
                85                  90                  95      


Val Thr Ile Cys Asn Ile Asn Pro Tyr Lys Tyr Ser Thr Val Arg His 
            100                 105                 110         


Leu Leu Ala Asp Leu Glu Gln Glu Thr Arg Glu Ala Leu Lys Ser Leu 
        115                 120                 125             


Tyr Gly Phe Pro Glu Ser Arg Lys Arg Arg Glu Ala Glu Ser Trp Asn 
    130                 135                 140                 


Ser Val Ser Glu Gly Lys Gln Pro Arg Phe Ser His Arg Ile Pro Leu 
145                 150                 155                 160 


Leu Ile Phe Asp Gln Asp Glu Lys Gly Lys Ala Arg Asp Phe Phe Thr 
                165                 170                 175     


Gly Arg Lys Arg Lys Val Gly Gly Ser Ile Ile His Lys Ala Ser Asn 
            180                 185                 190         


Val Met His Ile Glu Ser Lys Gln Val Val Gly Phe Gln Leu Cys Ser 
        195                 200                 205             


Asn Asp Thr Ser Asp Cys Ala Thr Tyr Thr Phe Ser Ser Gly Ile Asn 
    210                 215                 220                 


Ala Ile Gln Glu Trp Tyr Lys Leu His Tyr Met Asn Ile Met Ala Gln 
225                 230                 235                 240 


Val Pro Leu Glu Lys Lys Ile Asn Met Ser Tyr Ser Ala Glu Glu Leu 
                245                 250                 255     


Leu Val Thr Cys Phe Phe Asp Gly Val Ser Cys Asp Ala Arg Asn Phe 
            260                 265                 270         


Thr Leu Phe His His Pro Met His Gly Asn Cys Tyr Thr Phe Asn Asn 
        275                 280                 285             


Arg Glu Asn Glu Thr Ile Leu Ser Thr Ser Met Gly Gly Ser Glu Tyr 
    290                 295                 300                 


Gly Leu Gln Val Ile Leu Tyr Ile Asn Glu Glu Glu Tyr Asn Pro Phe 
305                 310                 315                 320 


Leu Val Ser Ser Thr Gly Ala Lys Val Ile Ile His Arg Gln Asp Glu 
                325                 330                 335     


Tyr Pro Phe Val Glu Asp Val Gly Thr Glu Ile Glu Thr Ala Met Val 
            340                 345                 350         


Thr Ser Ile Gly Met His Leu Thr Glu Ser Phe Lys Leu Ser Glu Pro 
        355                 360                 365             


Tyr Ser Gln Cys Thr Glu Asp Gly Ser Asp Val Pro Ile Arg Asn Ile 
    370                 375                 380                 


Tyr Asn Ala Ala Tyr Ser Leu Gln Ile Cys Leu His Ser Cys Phe Gln 
385                 390                 395                 400 


Thr Lys Met Val Glu Lys Cys Gly Cys Ala Gln Tyr Ser Gln Pro Leu 
                405                 410                 415     


Pro Pro Ala Ala Asn Tyr Cys Asn Tyr Gln Gln His Pro Asn Trp Met 
            420                 425                 430         


Tyr Cys Tyr Tyr Gln Leu His Arg Ala Phe Val Gln Glu Glu Leu Gly 
        435                 440                 445             


Cys Gln Ser Val Cys Lys Glu Ala Cys Ser Phe Lys Glu Trp Thr Leu 
    450                 455                 460                 


Thr Thr Ser Leu Ala Gln Trp Pro Ser Val Val Ser Glu Lys Trp Leu 
465                 470                 475                 480 


Leu Pro Val Leu Thr Trp Asp Gln Gly Arg Gln Val Asn Lys Lys Leu 
                485                 490                 495     


Asn Lys Thr Asp Leu Ala Lys Leu Leu Ile Phe Tyr Lys Asp Leu Asn 
            500                 505                 510         


Gln Arg Ser Ile Met Glu Ser Pro Ala Asn Ser Ile Glu Met Leu Leu 
        515                 520                 525             


Ser Asn Phe Gly Gly Gln Leu Gly Leu Trp Met Ser Cys Ser Val Val 
    530                 535                 540                 


Cys Val Ile Glu Ile Ile Glu Val Phe Phe Ile Asp Phe Phe Ser Ile 
545                 550                 555                 560 


Ile Ala Arg Arg Gln Trp Gln Lys Ala Lys Glu Trp Trp Ala Trp Lys 
                565                 570                 575     


Gln Ala Pro Pro Cys Pro Glu Ala Pro Arg Ser Pro Gln Gly Gln Asp 
            580                 585                 590         


Asn Pro Ala Leu Asp Ile Asp Asp Asp Leu Pro Thr Phe Asn Ser Ala 
        595                 600                 605             


Leu His Leu Pro Pro Ala Leu Gly Thr Gln Val Pro Gly Thr Pro Pro 
    610                 615                 620                 


Pro Lys Tyr Asn Thr Leu Arg Leu Glu Arg Ala Phe Ser Asn Gln Leu 
625                 630                 635                 640 


Thr Asp Thr Gln Met Leu Asp Glu Leu 
                645                 


<210>  760
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  760

Met Ala Glu Leu Val Pro Phe Ala Val Pro Ile Glu Ser Asp Lys Thr 
1               5                   10                  15      


Leu Leu Val Trp Glu Leu Ser Ser Gly Pro Thr Ala Glu Ala Leu His 
            20                  25                  30          


His Ser Leu Phe Thr Ala Phe Ser Gln Phe Gly Leu Leu Tyr Ser Val 
        35                  40                  45              


Arg Val Phe Pro Asn Ala Ala Val Ala His Pro Gly Phe Tyr Ala Val 
    50                  55                  60                  


Ile Lys Phe Tyr Ser Ala Arg Ala Ala His Arg Ala Gln Lys Ala Cys 
65                  70                  75                  80  


Asp Arg Lys Gln Leu Phe Gln Lys Ser Pro Val Lys Val Arg Leu Gly 
                85                  90                  95      


Thr Arg His Lys Ala Val Gln His Gln Ala Leu Ala Leu Asn Ser Ser 
            100                 105                 110         


Lys Cys Gln Glu Leu Ala Asn Tyr Tyr Phe Gly Phe Asn Gly Cys Ser 
        115                 120                 125             


Lys Arg Ile Ile Lys Leu Gln Glu Leu Ser Asp Leu Glu Glu Arg Glu 
    130                 135                 140                 


Asn Glu Asp Ser Met Val Pro Leu Pro Lys Gln Ser Leu Lys Phe Phe 
145                 150                 155                 160 


Cys Ala Leu Glu Val Val Leu Pro Ser Cys Asp Cys Arg Ser Pro Gly 
                165                 170                 175     


Ile Gly Leu Val Glu Glu Pro Met Asp Lys Val Glu Glu Gly Pro Leu 
            180                 185                 190         


Ser Phe Leu Met Lys Arg Lys Thr Ala Gln Lys Leu Ala Ile Gln Lys 
        195                 200                 205             


Ala Leu Ser Asp Ala Phe Gln Lys Leu Leu Ile Val Val Leu Gly Lys 
    210                 215                 220                 


Thr Val Leu Ile Ile Leu Glu Val Leu Gln Phe Gln 
225                 230                 235     


<210>  761
<211>  535
<212>  PRT
<213>  Homo sapiens

<400>  761

Met Ser Val His Tyr Thr Leu Asn Leu Arg Val Phe Trp Pro Leu Val 
1               5                   10                  15      


Thr Gly Leu Cys Thr Ala Leu Val Cys Leu Tyr His Val Leu Arg Gly 
            20                  25                  30          


Ser Gly Gly Ala Arg Ala Glu Pro Ala Asp Gly Val Asp Gly Gly Phe 
        35                  40                  45              


Pro Leu Leu Lys Val Ala Val Leu Leu Leu Leu Ser Tyr Val Leu Leu 
    50                  55                  60                  


Arg Cys Arg His Ala Val Arg Gln Arg Phe Leu Pro Gly Ser Pro Arg 
65                  70                  75                  80  


Leu Glu Gly His Ala Ala Phe Ser Ser Arg His Phe Arg Glu Pro Gly 
                85                  90                  95      


Leu Ser Ile Leu Leu Glu Ser Tyr Tyr Glu His Glu Val Arg Leu Ser 
            100                 105                 110         


Pro His Val Leu Gly His Ser Lys Ala His Val Ser Arg Ile Val Gly 
        115                 120                 125             


Glu Leu Val Arg Ala Gly Arg Ala Arg Gly Ser Pro Gly Leu Ile Pro 
    130                 135                 140                 


Gly Gly Ala Leu Ala Leu Ala Phe Arg Gly Asp Phe Ile Gln Val Gly 
145                 150                 155                 160 


Ser Ala Tyr Glu Gln His Lys Ile Arg Arg Pro Asp Ser Phe Asp Val 
                165                 170                 175     


Leu Val Pro Leu Arg Leu Pro Pro Leu Val Ala Leu Glu Pro Arg Ser 
            180                 185                 190         


Leu Gly Glu Glu Pro Ala Leu Ala Pro Ala Phe Arg Gly Cys Phe Leu 
        195                 200                 205             


Cys Ala Leu Lys Ala Pro Pro Ser Pro Ser Gly Ala Ser Gly Gly His 
    210                 215                 220                 


Trp Leu Arg Asp Cys Lys Pro Phe Ala Asp Ala Phe Cys Val Asp Val 
225                 230                 235                 240 


Arg Gly Arg Arg His Leu Ser Ala Thr Leu Val Leu Arg Trp Phe Gln 
                245                 250                 255     


Ser His Leu Gln Arg Ser Leu Ala Thr Val Arg Tyr Ser Leu Glu Gly 
            260                 265                 270         


Arg Cys Arg Val Thr Leu Thr Pro Gly Gly Leu Glu Gln Pro Pro Thr 
        275                 280                 285             


Leu His Ile Leu Pro Cys Arg Thr Asp Tyr Gly Cys Cys Arg Leu Ser 
    290                 295                 300                 


Met Ala Val Arg Leu Ile Pro Ala Val His Leu Gly Asp Gly Val Phe 
305                 310                 315                 320 


Leu Val Ala Pro Pro Pro Pro Pro Leu Pro Ser Ala Pro Leu Leu Glu 
                325                 330                 335     


Leu Pro Glu Gly Leu Arg Ala Glu Ala Leu Trp Gly Val Asn Thr Ala 
            340                 345                 350         


Arg Gln Glu Gln Lys Leu Leu Ser Trp Leu Gln Glu Arg Ala Ala Pro 
        355                 360                 365             


Gly Ala Cys Tyr Leu Lys Cys Leu Gln Leu Leu Lys Ala Leu Arg Asp 
    370                 375                 380                 


Leu Gly Ala Arg Gly Leu Asp Ser Ala Ala Ala Thr Gln Trp Gly Arg 
385                 390                 395                 400 


Ile Leu Ser Ser Tyr Val Leu Lys Thr Val Leu Leu Ala Val Leu Leu 
                405                 410                 415     


Arg Lys Gly Ala Pro Gly Gln Gly Trp Asp Glu Glu His Leu Gly Arg 
            420                 425                 430         


Cys Leu Glu Glu Leu Val Gln Phe Leu Arg Asp Cys Leu Leu Arg Arg 
        435                 440                 445             


His Thr Leu Phe His Cys Val Leu Gly Pro Gly Gly Ala Ala Ala Glu 
    450                 455                 460                 


Val Gly Pro Leu Pro Lys Ala Leu Arg Glu Ala Ala Pro Val Asp Leu 
465                 470                 475                 480 


Leu Ala Ala Phe Asp Gly His Ala Arg Glu Leu Ala Ala Ala Arg Leu 
                485                 490                 495     


Leu Ser Thr Trp Gln Arg Leu Pro Gln Leu Leu Arg Ala Tyr Gly Gly 
            500                 505                 510         


Pro Arg Tyr Leu Ala Arg Cys Pro Pro Pro Arg Ser Gln Arg Thr Gln 
        515                 520                 525             


Gly Phe Leu Glu Gly Glu Pro 
    530                 535 


<210>  762
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  762

Met Ala Ser Pro Ala Pro Pro Glu His Ala Glu Glu Gly Cys Pro Ala 
1               5                   10                  15      


Pro Ala Ala Glu Glu Gln Ala Pro Pro Ser Pro Pro Pro Pro Gln Ala 
            20                  25                  30          


Ser Pro Ala Glu Arg Gln Gln Gln Glu Glu Glu Ala Gln Glu Ala Gly 
        35                  40                  45              


Ala Ala Glu Gly Ala Gly Leu Gln Val Glu Glu Ala Ala Gly Arg Ala 
    50                  55                  60                  


Ala Ala Ala Val Thr Trp Leu Leu Gly Glu Pro Val Leu Trp Leu Gly 
65                  70                  75                  80  


Cys Arg Ala Asp Glu Leu Leu Ser Trp Lys Arg Pro Leu Arg Ser Leu 
                85                  90                  95      


Leu Gly Phe Val Ala Ala Asn Leu Leu Phe Trp Phe Leu Ala Leu Thr 
            100                 105                 110         


Pro Trp Arg Val Tyr His Leu Ile Ser Val Met Ile Leu Gly Arg Val 
        115                 120                 125             


Ile Met Gln Ile Ile Lys Asp Met Val Leu Ser Arg Thr Arg Gly Ala 
    130                 135                 140                 


Gln Leu Trp Arg Ser Leu Ser Glu Ser Trp Glu Val Ile Asn Ser Lys 
145                 150                 155                 160 


Pro Asp Glu Arg Pro Arg Leu Ser His Cys Ile Ala Glu Ser Trp Met 
                165                 170                 175     


Asn Phe Ser Ile Phe Leu Gln Glu Met Ser Leu Phe Lys Gln Gln Ser 
            180                 185                 190         


Pro Gly Lys Phe Cys Leu Leu Val Cys Ser Val Cys Thr Phe Phe Thr 
        195                 200                 205             


Ile Leu Gly Ser Tyr Ile Pro Gly Val Ile Leu Ser Tyr Leu Leu Leu 
    210                 215                 220                 


Leu Cys Ala Phe Leu Cys Pro Leu Phe Lys Cys Asn Asp Ile Gly Gln 
225                 230                 235                 240 


Lys Ile Tyr Ser Lys Ile Lys Ser Val Leu Leu Lys Leu Asp Phe Gly 
                245                 250                 255     


Ile Gly Glu Tyr Ile Asn Gln Lys Lys Arg Glu Arg Ser Glu Ala Asp 
            260                 265                 270         


Lys Glu Lys Ser His Lys Asp Asp Ser Glu Leu Asp Phe Ser Ala Leu 
        275                 280                 285             


Cys Pro Lys Ile Ser Leu Thr Val Ala Ala Lys Glu Leu Ser Val Ser 
    290                 295                 300                 


Asp Thr Asp Val Ser Glu Val Ser Trp Thr Asp Asn Gly Thr Phe Asn 
305                 310                 315                 320 


Leu Ser Glu Gly Tyr Thr Pro Gln Thr Asp Thr Ser Asp Asp Leu Asp 
                325                 330                 335     


Arg Pro Ser Glu Glu Val Phe Ser Arg Asp Leu Ser Asp Phe Pro Ser 
            340                 345                 350         


Leu Glu Asn Gly Met Gly Thr Asn Asp Glu Asp Glu Leu Ser Leu Gly 
        355                 360                 365             


Leu Pro Thr Glu Leu Lys Arg Lys Lys Glu Gln Leu Asp Ser Gly His 
    370                 375                 380                 


Arg Pro Ser Lys Glu Thr Gln Ser Ala Ala Gly Leu Thr Leu Pro Leu 
385                 390                 395                 400 


Asn Ser Asp Gln Thr Phe His Leu Met Ser Asn Leu Ala Gly Asp Val 
                405                 410                 415     


Ile Thr Ala Ala Val Thr Ala Ala Ile Lys Asp Gln Leu Glu Gly Val 
            420                 425                 430         


Gln Gln Ala Leu Ser Gln Ala Ala Pro Ile Pro Glu Glu Asp Thr Asp 
        435                 440                 445             


Thr Glu Glu Gly Asp Asp Phe Glu Leu Leu Asp Gln Ser Glu Leu Asp 
    450                 455                 460                 


Gln Ile Glu Ser Glu Leu Gly Leu Thr Gln Asp Gln Glu Ala Glu Ala 
465                 470                 475                 480 


Gln Gln Asn Lys Lys Ser Ser Gly Phe Leu Ser Asn Leu Leu Gly Gly 
                485                 490                 495     


His 
    


<210>  763
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  763

Met Gly Ile Gln Gly Met Glu Leu Cys Ala Met Ala Val Val Val Leu 
1               5                   10                  15      


Leu Phe Ile Ala Val Leu Lys Gln Phe Gly Ile Leu Glu Pro Ile Ser 
            20                  25                  30          


Met Glu Asp Ser Ser Asp Ser Glu Leu Glu Leu Ser Thr Val Arg His 
        35                  40                  45              


Gln Pro Glu Gly Leu Asp Gln Leu Gln Ala Gln Thr Lys Phe Thr Lys 
    50                  55                  60                  


Lys Glu Leu Gln Ser Leu Tyr Arg Gly Phe Lys Asn Glu Cys Pro Thr 
65                  70                  75                  80  


Gly Leu Val Asp Glu Asp Thr Phe Lys Leu Ile Tyr Ala Gln Phe Phe 
                85                  90                  95      


Pro Gln Gly Asp Ala Thr Thr Tyr Ala His Phe Leu Phe Asn Ala Phe 
            100                 105                 110         


Asp Ala Asp Gly Asn Gly Ala Ile His Phe Glu Asp Phe Val Val Gly 
        115                 120                 125             


Leu Ser Ile Leu Leu Arg Gly Thr Val His Glu Lys Leu Lys Trp Ala 
    130                 135                 140                 


Phe Asn Leu Tyr Asp Ile Asn Lys Asp Gly Tyr Ile Thr Lys Glu Glu 
145                 150                 155                 160 


Met Leu Ala Ile Met Lys Ser Ile Tyr Asp Met Met Gly Arg His Thr 
                165                 170                 175     


Tyr Pro Ile Leu Arg Glu Asp Ala Pro Ala Glu His Val Glu Arg Phe 
            180                 185                 190         


Phe Glu Lys Met Asp Arg Asn Gln Asp Gly Val Val Thr Ile Glu Glu 
        195                 200                 205             


Phe Leu Glu Ala Cys Gln Lys Asp Glu Asn Ile Met Ser Ser Met Gln 
    210                 215                 220                 


Leu Phe Glu Asn Val Ile 
225                 230 


<210>  764
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  764

Met Ala Ala Leu Leu Leu Arg His Val Gly Arg His Cys Leu Arg Ala 
1               5                   10                  15      


His Phe Ser Pro Gln Leu Cys Ile Arg Asn Ala Val Pro Leu Gly Thr 
            20                  25                  30          


Thr Ala Lys Glu Glu Met Glu Arg Phe Trp Asn Lys Asn Ile Gly Ser 
        35                  40                  45              


Asn Arg Pro Leu Ser Pro His Ile Thr Ile Tyr Ser Trp Ser Leu Pro 
    50                  55                  60                  


Met Ala Met Ser Ile Cys His Arg Gly Thr Gly Ile Ala Leu Ser Ala 
65                  70                  75                  80  


Asp Val Gly Pro Arg Lys Arg Pro Glu Asp Ser Pro Ala Ile Pro Val 
                85                  90                  95      


Trp Ser Gly Cys Pro Gly Ser Tyr Cys Val Val Leu Tyr Gly Ala Gly 
            100                 105                 110         


Ser His Val Lys Lys Gly Gly Ser Gln His His Leu Pro Thr His Tyr 
        115                 120                 125             


Tyr Ile His Pro Ser Phe Cys Leu Ser Phe Leu Ser Pro Ala Trp Glu 
    130                 135                 140                 


Lys Phe Ser Leu Phe Val 
145                 150 


<210>  765
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  765

Met Ala Ala Leu Leu Leu Arg His Val Gly Arg His Cys Leu Arg Ala 
1               5                   10                  15      


His Phe Ser Pro Gln Leu Cys Ile Arg Asn Trp Ser Leu Pro Met Ala 
            20                  25                  30          


Met Ser Ile Cys His Arg Gly Thr Gly Ile Ala Leu Ser Ala Gly Val 
        35                  40                  45              


Ser Leu Phe Gly Met Ser Ala Leu Leu Leu Pro Gly Asn Phe Glu Ser 
    50                  55                  60                  


Tyr Leu Glu Leu Val Lys Ser Leu Cys Leu Gly Pro Ala Leu Ile His 
65                  70                  75                  80  


Thr Ala Lys Phe Ala Leu Val Phe Pro Leu Met Tyr His Thr Trp Asn 
                85                  90                  95      


Gly Ile Arg His Leu Met Trp Asp Leu Gly Lys Gly Leu Lys Ile Pro 
            100                 105                 110         


Gln Leu Tyr Gln Ser Gly Val Val Val Leu Val Leu Thr Val Leu Ser 
        115                 120                 125             


Ser Met Gly Leu Ala Ala Met 
    130                 135 


<210>  766
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  766

Met Ala Ala Leu Leu Leu Ser Trp Ser Leu Pro Met Ala Met Ser Ile 
1               5                   10                  15      


Cys His Arg Gly Thr Gly Ile Ala Leu Ser Ala Gly Val Ser Leu Phe 
            20                  25                  30          


Gly Met Ser Ala Leu Leu Leu Pro Gly Asn Phe Glu Ser Tyr Leu Glu 
        35                  40                  45              


Leu Val Lys Ser Leu Cys Leu Gly Pro Ala Leu Ile His Thr Ala Lys 
    50                  55                  60                  


Phe Ala Leu Val Phe Pro Leu Met Tyr His Thr Trp Asn Gly Ile Arg 
65                  70                  75                  80  


His Leu Met Trp Asp Leu Gly Lys Gly Leu Lys Ile Pro Gln Leu Tyr 
                85                  90                  95      


Gln Ser Gly Val Val Val Leu Val Leu Thr Val Leu Ser Ser Met Gly 
            100                 105                 110         


Leu Ala Ala Met 
        115     


<210>  767
<211>  1827
<212>  PRT
<213>  Homo sapiens

<400>  767

Met Ala Arg Lys Lys Phe Ser Gly Leu Glu Ile Ser Leu Ile Val Leu 
1               5                   10                  15      


Phe Val Ile Val Thr Ile Ile Ala Ile Ala Leu Ile Val Val Leu Ala 
            20                  25                  30          


Thr Lys Thr Pro Ala Val Asp Glu Ile Ser Asp Ser Thr Ser Thr Pro 
        35                  40                  45              


Ala Thr Thr Arg Val Thr Thr Asn Pro Ser Asp Ser Gly Lys Cys Pro 
    50                  55                  60                  


Asn Val Leu Asn Asp Pro Val Asn Val Arg Ile Asn Cys Ile Pro Glu 
65                  70                  75                  80  


Gln Phe Pro Thr Glu Gly Ile Cys Ala Gln Arg Gly Cys Cys Trp Arg 
                85                  90                  95      


Pro Trp Asn Asp Ser Leu Ile Pro Trp Cys Phe Phe Val Asp Asn His 
            100                 105                 110         


Gly Tyr Asn Val Gln Asp Met Thr Thr Thr Ser Ile Gly Val Glu Ala 
        115                 120                 125             


Lys Leu Asn Arg Ile Pro Ser Pro Thr Leu Phe Gly Asn Asp Ile Asn 
    130                 135                 140                 


Ser Val Leu Phe Thr Thr Gln Asn Gln Thr Pro Asn Arg Phe Arg Phe 
145                 150                 155                 160 


Lys Ile Thr Asp Pro Asn Asn Arg Arg Tyr Glu Val Pro His Gln Tyr 
                165                 170                 175     


Val Lys Glu Phe Thr Gly Pro Thr Val Ser Asp Thr Leu Tyr Asp Val 
            180                 185                 190         


Lys Val Ala Gln Asn Pro Phe Ser Ile Gln Val Ile Arg Lys Ser Asn 
        195                 200                 205             


Gly Lys Thr Leu Phe Asp Thr Ser Ile Gly Pro Leu Val Tyr Ser Asp 
    210                 215                 220                 


Gln Tyr Leu Gln Ile Ser Thr Arg Leu Pro Ser Asp Tyr Ile Tyr Gly 
225                 230                 235                 240 


Ile Gly Glu Gln Val His Lys Arg Phe Arg His Asp Leu Ser Trp Lys 
                245                 250                 255     


Thr Trp Pro Ile Phe Thr Arg Asp Gln Leu Pro Gly Asp Asn Asn Asn 
            260                 265                 270         


Asn Leu Tyr Gly His Gln Thr Phe Phe Met Cys Ile Glu Asp Thr Ser 
        275                 280                 285             


Gly Lys Ser Phe Gly Val Phe Leu Met Asn Ser Asn Ala Met Glu Ile 
    290                 295                 300                 


Phe Ile Gln Pro Thr Pro Ile Val Thr Tyr Arg Val Thr Gly Gly Ile 
305                 310                 315                 320 


Leu Asp Phe Tyr Ile Leu Leu Gly Asp Thr Pro Glu Gln Val Val Gln 
                325                 330                 335     


Gln Tyr Gln Gln Leu Val Gly Leu Pro Ala Met Pro Ala Tyr Trp Asn 
            340                 345                 350         


Leu Gly Phe Gln Leu Ser Arg Trp Asn Tyr Lys Ser Leu Asp Val Val 
        355                 360                 365             


Lys Glu Val Val Arg Arg Asn Arg Glu Ala Gly Ile Pro Phe Asp Thr 
    370                 375                 380                 


Gln Val Thr Asp Ile Asp Tyr Met Glu Asp Lys Lys Asp Phe Thr Tyr 
385                 390                 395                 400 


Asp Gln Val Ala Phe Asn Gly Leu Pro Gln Phe Val Gln Asp Leu His 
                405                 410                 415     


Asp His Gly Gln Lys Tyr Val Ile Ile Leu Asp Pro Ala Ile Ser Ile 
            420                 425                 430         


Gly Arg Arg Ala Asn Gly Thr Thr Tyr Ala Thr Tyr Glu Arg Gly Asn 
        435                 440                 445             


Thr Gln His Val Trp Ile Asn Glu Ser Asp Gly Ser Thr Pro Ile Ile 
    450                 455                 460                 


Gly Glu Val Trp Pro Gly Leu Thr Val Tyr Pro Asp Phe Thr Asn Pro 
465                 470                 475                 480 


Asn Cys Ile Asp Trp Trp Ala Asn Glu Cys Ser Ile Phe His Gln Glu 
                485                 490                 495     


Val Gln Tyr Asp Gly Leu Trp Ile Asp Met Asn Glu Val Ser Ser Phe 
            500                 505                 510         


Ile Gln Gly Ser Thr Lys Gly Cys Asn Val Asn Lys Leu Asn Tyr Pro 
        515                 520                 525             


Pro Phe Thr Pro Asp Ile Leu Asp Lys Leu Met Tyr Ser Lys Thr Ile 
    530                 535                 540                 


Cys Met Asp Ala Val Gln Asn Trp Gly Lys Gln Tyr Asp Val His Ser 
545                 550                 555                 560 


Leu Tyr Gly Tyr Ser Met Ala Ile Ala Thr Glu Gln Ala Val Gln Lys 
                565                 570                 575     


Val Phe Pro Asn Lys Arg Ser Phe Ile Leu Thr Arg Ser Thr Phe Ala 
            580                 585                 590         


Gly Ser Gly Arg His Ala Ala His Trp Leu Gly Asp Asn Thr Ala Ser 
        595                 600                 605             


Trp Glu Gln Met Glu Trp Ser Ile Thr Gly Met Leu Glu Phe Ser Leu 
    610                 615                 620                 


Phe Gly Ile Pro Leu Val Gly Ala Asp Ile Cys Gly Phe Val Ala Glu 
625                 630                 635                 640 


Thr Thr Glu Glu Leu Cys Arg Arg Trp Met Gln Leu Gly Ala Phe Tyr 
                645                 650                 655     


Pro Phe Ser Arg Asn His Asn Ser Asp Gly Tyr Glu His Gln Asp Pro 
            660                 665                 670         


Ala Phe Phe Gly Gln Asn Ser Leu Leu Val Lys Ser Ser Arg Gln Tyr 
        675                 680                 685             


Leu Thr Ile Arg Tyr Thr Leu Leu Pro Phe Leu Tyr Thr Leu Phe Tyr 
    690                 695                 700                 


Lys Ala His Val Phe Gly Glu Thr Val Ala Arg Pro Val Leu His Glu 
705                 710                 715                 720 


Phe Tyr Glu Asp Thr Asn Ser Trp Ile Glu Asp Thr Glu Phe Leu Trp 
                725                 730                 735     


Gly Pro Ala Leu Leu Ile Thr Pro Val Leu Lys Gln Gly Ala Asp Thr 
            740                 745                 750         


Val Ser Ala Tyr Ile Pro Asp Ala Ile Trp Tyr Asp Tyr Glu Ser Gly 
        755                 760                 765             


Ala Lys Arg Pro Trp Arg Lys Gln Arg Val Asp Met Tyr Leu Pro Ala 
    770                 775                 780                 


Asp Lys Ile Gly Leu His Leu Arg Gly Gly Tyr Ile Ile Pro Ile Gln 
785                 790                 795                 800 


Glu Pro Asp Val Thr Thr Thr Ala Ser Arg Lys Asn Pro Leu Gly Leu 
                805                 810                 815     


Ile Val Ala Leu Gly Glu Asn Asn Thr Ala Lys Gly Asp Phe Phe Trp 
            820                 825                 830         


Asp Asp Gly Glu Thr Lys Asp Thr Ile Gln Asn Gly Asn Tyr Ile Leu 
        835                 840                 845             


Tyr Thr Phe Ser Val Ser Asn Asn Thr Leu Asp Ile Val Cys Thr His 
    850                 855                 860                 


Ser Ser Tyr Gln Glu Gly Thr Thr Leu Ala Phe Gln Thr Val Lys Ile 
865                 870                 875                 880 


Leu Gly Leu Thr Asp Ser Val Thr Glu Val Arg Val Ala Glu Asn Asn 
                885                 890                 895     


Gln Pro Met Asn Ala His Ser Asn Phe Thr Tyr Asp Ala Ser Asn Gln 
            900                 905                 910         


Val Leu Leu Ile Ala Asp Leu Lys Leu Asn Leu Gly Arg Asn Phe Ser 
        915                 920                 925             


Val Gln Trp Asn Gln Ile Phe Ser Glu Asn Glu Arg Phe Asn Cys Tyr 
    930                 935                 940                 


Pro Asp Ala Asp Leu Ala Thr Glu Gln Lys Cys Thr Gln Arg Gly Cys 
945                 950                 955                 960 


Val Trp Arg Thr Gly Ser Ser Leu Ser Lys Ala Pro Glu Cys Tyr Phe 
                965                 970                 975     


Pro Arg Gln Asp Asn Ser Tyr Ser Val Asn Ser Ala Arg Tyr Ser Ser 
            980                 985                 990         


Met Gly Ile Thr Ala Asp Leu Gln  Leu Asn Thr Ala Asn  Ala Arg Ile 
        995                 1000                 1005             


Lys Leu  Pro Ser Asp Pro Ile  Ser Thr Leu Arg Val  Glu Val Lys 
    1010                 1015                 1020             


Tyr His  Lys Asn Asp Met Leu  Gln Phe Lys Ile Tyr  Asp Pro Gln 
    1025                 1030                 1035             


Lys Lys  Arg Tyr Glu Val Pro  Val Pro Leu Asn Ile  Pro Thr Thr 
    1040                 1045                 1050             


Pro Ile  Ser Thr Tyr Glu Asp  Arg Leu Tyr Asp Val  Glu Ile Lys 
    1055                 1060                 1065             


Glu Asn  Pro Phe Gly Ile Gln  Ile Arg Arg Arg Ser  Ser Gly Arg 
    1070                 1075                 1080             


Val Ile  Trp Asp Ser Trp Leu  Pro Gly Phe Ala Phe  Asn Asp Gln 
    1085                 1090                 1095             


Phe Ile  Gln Ile Ser Thr Arg  Leu Pro Ser Glu Tyr  Ile Tyr Gly 
    1100                 1105                 1110             


Phe Gly  Glu Val Glu His Thr  Ala Phe Lys Arg Asp  Leu Asn Trp 
    1115                 1120                 1125             


Asn Thr  Trp Gly Met Phe Thr  Arg Asp Gln Pro Pro  Gly Tyr Lys 
    1130                 1135                 1140             


Leu Asn  Ser Tyr Gly Phe His  Pro Tyr Tyr Met Ala  Leu Glu Glu 
    1145                 1150                 1155             


Glu Gly  Asn Ala His Gly Val  Phe Leu Leu Asn Ser  Asn Ala Met 
    1160                 1165                 1170             


Asp Val  Thr Phe Gln Pro Thr  Pro Ala Leu Thr Tyr  Arg Thr Val 
    1175                 1180                 1185             


Gly Gly  Ile Leu Asp Phe Tyr  Met Phe Leu Gly Pro  Thr Pro Glu 
    1190                 1195                 1200             


Val Ala  Thr Lys Gln Tyr His  Glu Val Ile Gly His  Pro Val Met 
    1205                 1210                 1215             


Pro Ala  Tyr Trp Ala Leu Gly  Phe Gln Leu Cys Arg  Tyr Gly Tyr 
    1220                 1225                 1230             


Ala Asn  Thr Ser Glu Val Arg  Glu Leu Tyr Asp Ala  Met Val Ala 
    1235                 1240                 1245             


Ala Asn  Ile Pro Tyr Asp Val  Gln Tyr Thr Asp Ile  Asp Tyr Met 
    1250                 1255                 1260             


Glu Arg  Gln Leu Asp Phe Thr  Ile Gly Glu Ala Phe  Gln Asp Leu 
    1265                 1270                 1275             


Pro Gln  Phe Val Asp Lys Ile  Arg Gly Glu Gly Met  Arg Tyr Ile 
    1280                 1285                 1290             


Ile Ile  Leu Asp Pro Ala Ile  Ser Gly Asn Glu Thr  Lys Thr Tyr 
    1295                 1300                 1305             


Pro Ala  Phe Glu Arg Gly Gln  Gln Asn Asp Val Phe  Val Lys Trp 
    1310                 1315                 1320             


Pro Asn  Thr Asn Asp Ile Cys  Trp Ala Lys Val Trp  Pro Asp Leu 
    1325                 1330                 1335             


Pro Asn  Ile Thr Ile Asp Lys  Thr Leu Thr Glu Asp  Glu Ala Val 
    1340                 1345                 1350             


Asn Ala  Ser Arg Ala His Val  Ala Phe Pro Asp Phe  Phe Arg Thr 
    1355                 1360                 1365             


Ser Thr  Ala Glu Trp Trp Ala  Arg Glu Ile Val Asp  Phe Tyr Asn 
    1370                 1375                 1380             


Glu Lys  Met Lys Phe Asp Gly  Leu Trp Ile Asp Met  Asn Glu Pro 
    1385                 1390                 1395             


Ser Ser  Phe Val Asn Gly Thr  Thr Thr Asn Gln Cys  Arg Asn Asp 
    1400                 1405                 1410             


Glu Leu  Asn Tyr Pro Pro Tyr  Phe Pro Glu Leu Thr  Lys Arg Thr 
    1415                 1420                 1425             


Asp Gly  Leu His Phe Arg Thr  Ile Cys Met Glu Ala  Glu Gln Ile 
    1430                 1435                 1440             


Leu Ser  Asp Gly Thr Ser Val  Leu His Tyr Asp Val  His Asn Leu 
    1445                 1450                 1455             


Tyr Gly  Trp Ser Gln Met Lys  Pro Thr His Asp Ala  Leu Gln Lys 
    1460                 1465                 1470             


Thr Thr  Gly Lys Arg Gly Ile  Val Ile Ser Arg Ser  Thr Tyr Pro 
    1475                 1480                 1485             


Thr Ser  Gly Arg Trp Gly Gly  His Trp Leu Gly Asp  Asn Tyr Ala 
    1490                 1495                 1500             


Arg Trp  Asp Asn Met Asp Lys  Ser Ile Ile Gly Met  Met Glu Phe 
    1505                 1510                 1515             


Ser Leu  Phe Gly Met Ser Tyr  Thr Gly Ala Asp Ile  Cys Gly Phe 
    1520                 1525                 1530             


Phe Asn  Asn Ser Glu Tyr His  Leu Cys Thr Arg Trp  Met Gln Leu 
    1535                 1540                 1545             


Gly Ala  Phe Tyr Pro Tyr Ser  Arg Asn His Asn Ile  Ala Asn Thr 
    1550                 1555                 1560             


Arg Arg  Gln Asp Pro Ala Ser  Trp Asn Glu Thr Phe  Ala Glu Met 
    1565                 1570                 1575             


Ser Arg  Asn Ile Leu Asn Ile  Arg Tyr Thr Leu Leu  Pro Tyr Phe 
    1580                 1585                 1590             


Tyr Thr  Gln Met His Glu Ile  His Ala Asn Gly Gly  Thr Val Ile 
    1595                 1600                 1605             


Arg Pro  Leu Leu His Glu Phe  Phe Asp Glu Lys Pro  Thr Trp Asp 
    1610                 1615                 1620             


Ile Phe  Lys Gln Phe Leu Trp  Gly Pro Ala Phe Met  Val Thr Pro 
    1625                 1630                 1635             


Val Leu  Glu Pro Tyr Val Gln  Thr Val Asn Ala Tyr  Val Pro Asn 
    1640                 1645                 1650             


Ala Arg  Trp Phe Asp Tyr His  Thr Gly Lys Asp Ile  Gly Val Arg 
    1655                 1660                 1665             


Gly Gln  Phe Gln Thr Phe Asn  Ala Ser Tyr Asp Thr  Ile Asn Leu 
    1670                 1675                 1680             


His Val  Arg Gly Gly His Ile  Leu Pro Cys Gln Glu  Pro Ala Gln 
    1685                 1690                 1695             


Asn Thr  Phe Tyr Ser Arg Gln  Lys His Met Lys Leu  Ile Val Ala 
    1700                 1705                 1710             


Ala Asp  Asp Asn Gln Met Ala  Gln Gly Ser Leu Phe  Trp Asp Asp 
    1715                 1720                 1725             


Gly Glu  Ser Ile Asp Thr Tyr  Glu Arg Asp Leu Tyr  Leu Ser Val 
    1730                 1735                 1740             


Gln Phe  Asn Leu Asn Gln Thr  Thr Leu Thr Ser Thr  Ile Leu Lys 
    1745                 1750                 1755             


Arg Gly  Tyr Ile Asn Lys Ser  Glu Thr Arg Leu Gly  Ser Leu His 
    1760                 1765                 1770             


Val Trp  Gly Lys Gly Thr Thr  Pro Val Asn Ala Val  Thr Leu Thr 
    1775                 1780                 1785             


Tyr Asn  Gly Asn Lys Asn Ser  Leu Pro Phe Asn Glu  Asp Thr Thr 
    1790                 1795                 1800             


Asn Met  Ile Leu Arg Ile Asp  Leu Thr Thr His Asn  Val Thr Leu 
    1805                 1810                 1815             


Glu Glu  Pro Ile Glu Ile Asn  Trp Ser 
    1820                 1825         


<210>  768
<211>  1304
<212>  PRT
<213>  Homo sapiens

<400>  768

Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg 
1               5                   10                  15      


Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val 
            20                  25                  30          


Pro Leu Asp Pro Lys Leu Leu Glu Asp Leu Val Gln Pro Pro Thr Ile 
        35                  40                  45              


Thr Gln Gln Ser Pro Lys Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile 
    50                  55                  60                  


Val Ile Gln Cys Glu Ala Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp 
65                  70                  75                  80  


Thr Arg Asn Gly Thr His Phe Asp Ile Asp Lys Asp Pro Leu Val Thr 
                85                  90                  95      


Met Lys Pro Gly Thr Gly Thr Leu Ile Ile Asn Ile Met Ser Glu Gly 
            100                 105                 110         


Lys Ala Glu Thr Tyr Glu Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu 
        115                 120                 125             


Arg Gly Ala Ala Val Ser Asn Asn Ile Val Val Arg Pro Ser Arg Ser 
    130                 135                 140                 


Pro Leu Trp Thr Lys Glu Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly 
145                 150                 155                 160 


Gln Ser Leu Val Leu Pro Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro 
                165                 170                 175     


Ile Ile Phe Trp Met Asp Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu 
            180                 185                 190         


Arg Val Ser Gln Gly Leu Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu 
        195                 200                 205             


Pro Glu Asp Thr Arg Glu Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His 
    210                 215                 220                 


Thr Gln Thr Ile Gln Gln Lys Gln Pro Ile Ser Val Lys Val Ile Ser 
225                 230                 235                 240 


Val Asp Glu Leu Asn Asp Thr Ile Ala Ala Asn Leu Ser Asp Thr Glu 
                245                 250                 255     


Phe Tyr Gly Ala Lys Ser Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr 
            260                 265                 270         


Pro Glu Gly Asn Ala Ser Asn Lys Glu Glu Leu Arg Gly Asn Val Leu 
        275                 280                 285             


Ser Leu Glu Cys Ile Ala Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp 
    290                 295                 300                 


Ala Lys Glu Asp Gly Met Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn 
305                 310                 315                 320 


Phe Glu Lys Thr Leu Gln Ile Ile His Val Ser Glu Ala Asp Ser Gly 
                325                 330                 335     


Asn Tyr Gln Cys Ile Ala Lys Asn Ala Leu Gly Ala Ile His His Thr 
            340                 345                 350         


Ile Ser Val Arg Val Lys Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln 
        355                 360                 365             


Asn Leu Val Leu Ser Pro Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala 
    370                 375                 380                 


Asn Gly Asn Pro Lys Pro Arg Ile Ser Trp Leu Thr Asn Gly Val Pro 
385                 390                 395                 400 


Ile Glu Ile Ala Pro Asp Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr 
                405                 410                 415     


Ile Ile Phe Ser Asn Val Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys 
            420                 425                 430         


Asn Ala Ser Asn Glu Tyr Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn 
        435                 440                 445             


Val Leu Ala Glu Pro Pro Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr 
    450                 455                 460                 


Gln Val Ile Ala Asn Arg Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly 
465                 470                 475                 480 


Ser Pro Leu Pro Thr Ile Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala 
                485                 490                 495     


Leu His Glu Asp Ile Tyr Val Leu His Glu Asn Gly Thr Leu Glu Ile 
            500                 505                 510         


Pro Val Ala Gln Lys Asp Ser Thr Gly Thr Tyr Thr Cys Val Ala Arg 
        515                 520                 525             


Asn Lys Leu Gly Met Ala Lys Asn Glu Val His Leu Glu Ile Lys Asp 
    530                 535                 540                 


Pro Thr Trp Ile Val Lys Gln Pro Glu Tyr Ala Val Val Gln Arg Gly 
545                 550                 555                 560 


Ser Met Val Ser Phe Glu Cys Lys Val Lys His Asp His Thr Leu Ser 
                565                 570                 575     


Leu Thr Val Leu Trp Leu Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu 
            580                 585                 590         


Arg Phe Thr Val Asp Lys Asp His Leu Val Val Ala Asp Val Ser Asp 
        595                 600                 605             


Asp Asp Ser Gly Thr Tyr Thr Cys Val Ala Asn Thr Thr Leu Asp Ser 
    610                 615                 620                 


Val Ser Ala Ser Ala Val Leu Ser Val Val Ala Pro Thr Pro Thr Pro 
625                 630                 635                 640 


Ala Pro Val Tyr Asp Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr 
                645                 650                 655     


Asp Gln Leu Asp Lys Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp 
            660                 665                 670         


Asn Asn Ser Pro Ile Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met 
        675                 680                 685             


His Lys Pro Gly Leu Trp His His Gln Thr Glu Val Ser Gly Thr Gln 
    690                 695                 700                 


Thr Thr Ala Gln Leu Lys Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg 
705                 710                 715                 720 


Val Met Ala Val Asn Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser 
                725                 730                 735     


Glu Gln Tyr Leu Thr Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala 
            740                 745                 750         


Val Glu Gly Leu Gly Ser Glu Pro Asp Asn Leu Val Ile Thr Trp Lys 
        755                 760                 765             


Pro Leu Asn Gly Phe Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val 
    770                 775                 780                 


Ser Trp Arg Gln Lys Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val 
785                 790                 795                 800 


Ala Asn Val Ser Lys Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro 
                805                 810                 815     


Tyr Leu Ile Lys Val Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu 
            820                 825                 830         


Pro Ala Val Val Met Gly His Ser Gly Glu Asp Leu Pro Met Val Ala 
        835                 840                 845             


Pro Gly Asn Val Arg Val Asn Val Val Asn Ser Thr Leu Ala Glu Val 
    850                 855                 860                 


His Trp Asp Pro Val Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly 
865                 870                 875                 880 


Tyr Arg Ile Tyr Tyr Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg 
                885                 890                 895     


Arg His Ile Glu Lys Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His 
            900                 905                 910         


Gly Met Leu Pro Gly Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val 
        915                 920                 925             


Arg Val Val Asn Gly Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val 
    930                 935                 940                 


Phe Asn Thr Pro Glu Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile 
945                 950                 955                 960 


Val Asn Pro Thr Leu Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser 
                965                 970                 975     


His Pro Asn Gly Ile Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile 
            980                 985                 990         


Asn Ser Thr His Glu Leu Gly Pro  Leu Val Asp Leu Lys  Ile Pro Ala 
        995                 1000                 1005             


Asn Lys  Thr Arg Trp Thr Leu  Lys Asn Leu Asn Phe  Ser Thr Arg 
    1010                 1015                 1020             


Tyr Lys  Phe Tyr Phe Tyr Ala  Gln Thr Ser Ala Gly  Ser Gly Ser 
    1025                 1030                 1035             


Gln Ile  Thr Glu Glu Ala Val  Thr Thr Val Asp Glu  Ala Gly Ile 
    1040                 1045                 1050             


Leu Pro  Pro Asp Val Gly Ala  Gly Lys Val Gln Ala  Val Asn Pro 
    1055                 1060                 1065             


Arg Ile  Ser Asn Leu Thr Ala  Ala Ala Ala Glu Thr  Tyr Ala Asn 
    1070                 1075                 1080             


Ile Ser  Trp Glu Tyr Glu Gly  Pro Glu His Val Asn  Phe Tyr Val 
    1085                 1090                 1095             


Glu Tyr  Gly Val Ala Gly Ser  Lys Glu Glu Trp Arg  Lys Glu Ile 
    1100                 1105                 1110             


Val Asn  Gly Ser Arg Ser Phe  Phe Gly Leu Lys Gly  Leu Met Pro 
    1115                 1120                 1125             


Gly Thr  Ala Tyr Lys Val Arg  Val Gly Ala Val Gly  Asp Ser Gly 
    1130                 1135                 1140             


Phe Val  Ser Ser Glu Asp Val  Phe Glu Thr Gly Pro  Ala Met Ala 
    1145                 1150                 1155             


Ser Arg  Gln Val Asp Ile Ala  Thr Gln Gly Trp Phe  Ile Gly Leu 
    1160                 1165                 1170             


Met Cys  Ala Val Ala Leu Leu  Ile Leu Ile Leu Leu  Ile Val Cys 
    1175                 1180                 1185             


Phe Ile  Arg Arg Asn Lys Gly  Gly Lys Tyr Pro Val  Lys Glu Lys 
    1190                 1195                 1200             


Glu Asp  Ala His Ala Asp Pro  Glu Ile Gln Pro Met  Lys Glu Asp 
    1205                 1210                 1215             


Asp Gly  Thr Phe Gly Glu Tyr  Ser Asp Ala Glu Asp  His Lys Pro 
    1220                 1225                 1230             


Leu Lys  Lys Gly Ser Arg Thr  Pro Ser Asp Arg Thr  Val Lys Lys 
    1235                 1240                 1245             


Glu Asp  Ser Asp Asp Ser Leu  Val Asp Tyr Gly Glu  Gly Val Asn 
    1250                 1255                 1260             


Gly Gln  Phe Asn Glu Asp Gly  Ser Phe Ile Gly Gln  Tyr Ser Gly 
    1265                 1270                 1275             


Lys Lys  Glu Lys Glu Pro Ala  Glu Gly Asn Glu Ser  Ser Glu Ala 
    1280                 1285                 1290             


Pro Ser  Pro Val Asn Ala Met  Asn Ser Phe Val 
    1295                 1300                 


<210>  769
<211>  1304
<212>  PRT
<213>  Homo sapiens

<400>  769

Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg 
1               5                   10                  15      


Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val 
            20                  25                  30          


Pro Leu Asp Pro Lys Leu Leu Glu Asp Leu Val Gln Pro Pro Thr Ile 
        35                  40                  45              


Thr Gln Gln Ser Pro Lys Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile 
    50                  55                  60                  


Val Ile Gln Cys Glu Ala Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp 
65                  70                  75                  80  


Thr Arg Asn Gly Thr His Phe Asp Ile Asp Lys Asp Pro Leu Val Thr 
                85                  90                  95      


Met Lys Pro Gly Thr Gly Thr Leu Ile Ile Asn Ile Met Ser Glu Gly 
            100                 105                 110         


Lys Ala Glu Thr Tyr Glu Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu 
        115                 120                 125             


Arg Gly Ala Ala Val Ser Asn Asn Ile Val Val Arg Pro Ser Arg Ser 
    130                 135                 140                 


Pro Leu Trp Thr Lys Glu Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly 
145                 150                 155                 160 


Gln Ser Leu Val Leu Pro Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro 
                165                 170                 175     


Ile Ile Phe Trp Met Asp Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu 
            180                 185                 190         


Arg Val Ser Gln Gly Leu Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu 
        195                 200                 205             


Pro Glu Asp Thr Arg Glu Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His 
    210                 215                 220                 


Thr Gln Thr Ile Gln Gln Lys Gln Pro Ile Ser Val Lys Val Ile Ser 
225                 230                 235                 240 


Val Asp Glu Leu Asn Asp Thr Ile Ala Ala Asn Leu Ser Asp Thr Glu 
                245                 250                 255     


Phe Tyr Gly Ala Lys Ser Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr 
            260                 265                 270         


Pro Glu Gly Asn Ala Ser Asn Lys Glu Glu Leu Arg Gly Asn Val Leu 
        275                 280                 285             


Ser Leu Glu Cys Ile Ala Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp 
    290                 295                 300                 


Ala Lys Glu Asp Gly Met Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn 
305                 310                 315                 320 


Phe Glu Lys Thr Leu Gln Ile Ile His Val Ser Glu Ala Asp Ser Gly 
                325                 330                 335     


Asn Tyr Gln Cys Ile Ala Lys Asn Ala Leu Gly Ala Ile His His Thr 
            340                 345                 350         


Ile Ser Val Arg Val Lys Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln 
        355                 360                 365             


Asn Leu Val Leu Ser Pro Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala 
    370                 375                 380                 


Asn Gly Asn Pro Lys Pro Arg Ile Ser Trp Leu Thr Asn Gly Val Pro 
385                 390                 395                 400 


Ile Glu Ile Ala Pro Asp Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr 
                405                 410                 415     


Ile Ile Phe Ser Asn Val Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys 
            420                 425                 430         


Asn Ala Ser Asn Glu Tyr Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn 
        435                 440                 445             


Val Leu Ala Glu Pro Pro Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr 
    450                 455                 460                 


Gln Val Ile Ala Asn Arg Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly 
465                 470                 475                 480 


Ser Pro Leu Pro Thr Ile Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala 
                485                 490                 495     


Leu His Glu Asp Ile Tyr Val Leu His Glu Asn Gly Thr Leu Glu Ile 
            500                 505                 510         


Pro Val Ala Gln Lys Asp Ser Thr Gly Thr Tyr Thr Cys Val Ala Arg 
        515                 520                 525             


Asn Lys Leu Gly Met Ala Lys Asn Glu Val His Leu Glu Ile Lys Asp 
    530                 535                 540                 


Pro Thr Trp Ile Val Lys Gln Pro Glu Tyr Ala Val Val Gln Arg Gly 
545                 550                 555                 560 


Ser Met Val Ser Phe Glu Cys Lys Val Lys His Asp His Thr Leu Ser 
                565                 570                 575     


Leu Thr Val Leu Trp Leu Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu 
            580                 585                 590         


Arg Phe Thr Val Asp Lys Asp His Leu Val Val Ala Asp Val Ser Asp 
        595                 600                 605             


Asp Asp Ser Gly Thr Tyr Thr Cys Val Ala Asn Thr Thr Leu Asp Ser 
    610                 615                 620                 


Val Ser Ala Ser Ala Val Leu Ser Val Val Ala Pro Thr Pro Thr Pro 
625                 630                 635                 640 


Ala Pro Val Tyr Asp Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr 
                645                 650                 655     


Asp Gln Leu Asp Lys Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp 
            660                 665                 670         


Asn Asn Ser Pro Ile Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met 
        675                 680                 685             


His Lys Pro Gly Leu Trp His His Gln Thr Glu Val Ser Gly Thr Gln 
    690                 695                 700                 


Thr Thr Ala Gln Leu Lys Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg 
705                 710                 715                 720 


Val Met Ala Val Asn Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser 
                725                 730                 735     


Glu Gln Tyr Leu Thr Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala 
            740                 745                 750         


Val Glu Gly Leu Gly Ser Glu Pro Asp Asn Leu Val Ile Thr Trp Lys 
        755                 760                 765             


Pro Leu Asn Gly Phe Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val 
    770                 775                 780                 


Ser Trp Arg Gln Lys Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val 
785                 790                 795                 800 


Ala Asn Val Ser Lys Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro 
                805                 810                 815     


Tyr Leu Ile Lys Val Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu 
            820                 825                 830         


Pro Ala Val Val Met Gly His Ser Gly Glu Asp Leu Pro Met Val Ala 
        835                 840                 845             


Pro Gly Asn Val Arg Val Asn Val Val Asn Ser Thr Leu Ala Glu Val 
    850                 855                 860                 


His Trp Asp Pro Val Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly 
865                 870                 875                 880 


Tyr Arg Ile Tyr Tyr Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg 
                885                 890                 895     


Arg His Ile Glu Lys Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His 
            900                 905                 910         


Gly Met Leu Pro Gly Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val 
        915                 920                 925             


Arg Val Val Asn Gly Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val 
    930                 935                 940                 


Phe Asn Thr Pro Glu Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile 
945                 950                 955                 960 


Val Asn Pro Thr Leu Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser 
                965                 970                 975     


His Pro Asn Gly Ile Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile 
            980                 985                 990         


Asn Ser Thr His Glu Leu Gly Pro  Leu Val Asp Leu Lys  Ile Pro Ala 
        995                 1000                 1005             


Asn Lys  Thr Arg Trp Thr Leu  Lys Asn Leu Asn Phe  Ser Thr Arg 
    1010                 1015                 1020             


Tyr Lys  Phe Tyr Phe Tyr Ala  Gln Thr Ser Ala Gly  Ser Gly Ser 
    1025                 1030                 1035             


Gln Ile  Thr Glu Glu Ala Val  Thr Thr Val Asp Glu  Ala Gly Ile 
    1040                 1045                 1050             


Leu Pro  Pro Asp Val Gly Ala  Gly Lys Val Gln Ala  Val Asn Pro 
    1055                 1060                 1065             


Arg Ile  Ser Asn Leu Thr Ala  Ala Ala Ala Glu Thr  Tyr Ala Asn 
    1070                 1075                 1080             


Ile Ser  Trp Glu Tyr Glu Gly  Pro Glu His Val Asn  Phe Tyr Val 
    1085                 1090                 1095             


Glu Tyr  Gly Val Ala Gly Ser  Lys Glu Glu Trp Arg  Lys Glu Ile 
    1100                 1105                 1110             


Val Asn  Gly Ser Arg Ser Phe  Phe Gly Leu Lys Gly  Leu Met Pro 
    1115                 1120                 1125             


Gly Thr  Ala Tyr Lys Val Arg  Val Gly Ala Val Gly  Asp Ser Gly 
    1130                 1135                 1140             


Phe Val  Ser Ser Glu Asp Val  Phe Glu Thr Gly Pro  Ala Met Ala 
    1145                 1150                 1155             


Ser Arg  Gln Val Asp Ile Ala  Thr Gln Gly Trp Phe  Ile Gly Leu 
    1160                 1165                 1170             


Met Cys  Ala Val Ala Leu Leu  Ile Leu Ile Leu Leu  Ile Val Cys 
    1175                 1180                 1185             


Phe Ile  Arg Arg Asn Lys Gly  Gly Lys Tyr Pro Val  Lys Glu Lys 
    1190                 1195                 1200             


Glu Asp  Ala His Ala Asp Pro  Glu Ile Gln Pro Met  Lys Glu Asp 
    1205                 1210                 1215             


Asp Gly  Thr Phe Gly Glu Tyr  Ser Asp Ala Glu Asp  His Lys Pro 
    1220                 1225                 1230             


Leu Lys  Lys Gly Ser Arg Thr  Pro Ser Asp Arg Thr  Val Lys Lys 
    1235                 1240                 1245             


Glu Asp  Ser Asp Asp Ser Leu  Val Asp Tyr Gly Glu  Gly Val Asn 
    1250                 1255                 1260             


Gly Gln  Phe Asn Glu Asp Gly  Ser Phe Ile Gly Gln  Tyr Ser Gly 
    1265                 1270                 1275             


Lys Lys  Glu Lys Glu Pro Ala  Glu Gly Asn Glu Ser  Ser Glu Ala 
    1280                 1285                 1290             


Pro Ser  Pro Val Asn Ala Met  Asn Ser Phe Val 
    1295                 1300                 


<210>  770
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  770

Met Leu Phe Arg Asn Arg Phe Leu Leu Leu Leu Ala Leu Ala Ala Leu 
1               5                   10                  15      


Leu Ala Phe Val Ser Leu Ser Leu Gln Phe Phe His Leu Ile Pro Val 
            20                  25                  30          


Ser Thr Pro Lys Asn Gly Met Ser Ser Lys Ser Arg Lys Arg Ile Met 
        35                  40                  45              


Pro Asp Pro Val Thr Glu Pro Pro Val Thr Asp Pro Val Tyr Glu Ala 
    50                  55                  60                  


Leu Leu Tyr Cys Asn Ile Pro Ser Val Ala Glu Arg Ser Met Glu Gly 
65                  70                  75                  80  


His Ala Pro His His Phe Lys Leu Val Ser Val His Val Phe Ile Arg 
                85                  90                  95      


His Gly Asp Arg Tyr Pro Leu Tyr Val Ile Pro Lys Thr Lys Arg Pro 
            100                 105                 110         


Glu Ile Asp Cys Thr Leu Val Ala Asn Arg Lys Pro Tyr His Pro Lys 
        115                 120                 125             


Leu Glu Ala Phe Ile Ser His Met Ser Lys Gly Ser Gly Ala Ser Phe 
    130                 135                 140                 


Glu Ser Pro Leu Asn Ser Leu Pro Leu Tyr Pro Asn His Pro Leu Cys 
145                 150                 155                 160 


Glu Met Gly Glu Leu Thr Gln Thr Gly Val Val Gln His Leu Gln Asn 
                165                 170                 175     


Gly Gln Leu Leu Arg Asp Ile Tyr Leu Lys Lys His Lys Leu Leu Pro 
            180                 185                 190         


Asn Asp Trp Ser Ala Asp Gln Leu Tyr Leu Glu Thr Thr Gly Lys Ser 
        195                 200                 205             


Arg Thr Leu Gln Ser Gly Leu Ala Leu Leu Tyr Gly Phe Leu Pro Asp 
    210                 215                 220                 


Phe Asp Trp Lys Lys Ile Tyr Phe Arg His Gln Pro Ser Ala Leu Phe 
225                 230                 235                 240 


Cys Ser Gly Ser Cys Tyr Cys Pro Val Arg Asn Gln Tyr Leu Glu Lys 
                245                 250                 255     


Glu Gln Arg Arg Gln Tyr Leu Leu Arg Leu Lys Asn Ser Gln Leu Glu 
            260                 265                 270         


Lys Thr Tyr Gly Glu Met Ala Lys Ile Val Asp Val Pro Thr Lys Gln 
        275                 280                 285             


Leu Arg Ala Ala Asn Pro Ile Asp Ser Met Leu Cys His Phe Cys His 
    290                 295                 300                 


Asn Val Ser Phe Pro Cys Thr Arg Asn Gly Cys Val Asp Met Glu His 
305                 310                 315                 320 


Phe Lys Val Ile Lys Thr His Gln Ile Glu Asp Glu Arg Glu Arg Arg 
                325                 330                 335     


Glu Lys Lys Leu Tyr Phe Gly Tyr Ser Leu Leu Gly Ala His Pro Ile 
            340                 345                 350         


Leu Asn Gln Thr Ile Gly Arg Met Gln Arg Ala Thr Glu Gly Arg Lys 
        355                 360                 365             


Glu Glu Leu Phe Ala Leu Tyr Ser Ala His Asp Val Thr Leu Ser Pro 
    370                 375                 380                 


Val Leu Ser Ala Leu Gly Leu Ser Glu Ala Arg Phe Pro Arg Phe Ala 
385                 390                 395                 400 


Ala Arg Leu Ile Phe Glu Leu Trp Gln Asp Arg Glu Lys Pro Ser Glu 
                405                 410                 415     


His Ser Val Arg Ile Leu Tyr Asn Gly Val Asp Val Thr Phe His Thr 
            420                 425                 430         


Ser Phe Cys Gln Asp His His Lys Arg Ser Pro Lys Pro Met Cys Pro 
        435                 440                 445             


Leu Glu Asn Leu Val Arg Phe Val Lys Arg Asp Met Phe Val Ala Leu 
    450                 455                 460                 


Gly Gly Ser Gly Thr Asn Tyr Tyr Asp Ala Cys His Arg Glu Gly Phe 
465                 470                 475                 480 


<210>  771
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  771

Met Tyr His Gly Met Asn Pro Ser Asn Gly Asp Gly Phe Leu Glu Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Pro Gln Ser Pro Gln Arg Leu Leu Ala Val 
            20                  25                  30          


Ile Leu Trp Phe Gln Leu Ala Leu Cys Phe Gly Pro Ala Gln Leu Thr 
        35                  40                  45              


Gly Gly Phe Asp Asp Leu Gln Val Cys Ala Asp Pro Gly Ile Pro Glu 
    50                  55                  60                  


Asn Gly Phe Arg Thr Pro Ser Gly Gly Val Phe Phe Glu Gly Ser Val 
65                  70                  75                  80  


Ala Arg Phe His Cys Gln Asp Gly Phe Lys Leu Lys Gly Ala Thr Lys 
                85                  90                  95      


Arg Leu Cys Leu Lys His Phe Asn Gly Thr Leu Gly Trp Ile Pro Ser 
            100                 105                 110         


Asp Asn Ser Ile Cys Val Gln Glu Asp Cys Arg Ile Pro Gln Ile Glu 
        115                 120                 125             


Asp Ala Glu Ile His Asn Lys Thr Tyr Arg His Gly Glu Lys Leu Ile 
    130                 135                 140                 


Ile Thr Cys His Glu Gly Phe Lys Ile Arg Tyr Pro Asp Leu His Asn 
145                 150                 155                 160 


Met Val Ser Leu Cys Arg Asp Asp Gly Thr Trp Asn Asn Leu Pro Ile 
                165                 170                 175     


Cys Gln Gly Cys Leu Arg Pro Leu Ala Ser Ser Asn Gly Tyr Val Asn 
            180                 185                 190         


Ile Ser Glu Leu Gln Thr Ser Phe Pro Val Gly Thr Val Ile Ser Tyr 
        195                 200                 205             


Arg Cys Phe Pro Gly Phe Lys Leu Asp Gly Ser Ala Tyr Leu Glu Cys 
    210                 215                 220                 


Leu Gln Asn Leu Ile Trp Ser Ser Ser Pro Pro Arg Cys Leu Ala Leu 
225                 230                 235                 240 


Glu Gly Gly Arg Pro Glu His Leu Phe Pro Val Leu Tyr Phe Pro His 
                245                 250                 255     


Ile Arg Leu Ala Ala Ala Val Leu Tyr Phe Cys Pro Val Leu Lys Ser 
            260                 265                 270         


Ser Pro Thr Pro Ala Pro Thr Cys Ser Ser Thr Ser Thr Thr Thr Ser 
        275                 280                 285             


Leu Phe 
    290 


<210>  772
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  772

Met Leu Ser Ala Arg Asp Arg Arg Asp Arg His Pro Glu Glu Gly Val 
1               5                   10                  15      


Val Ala Glu Leu Gln Gly Phe Ala Val Asp Lys Ala Phe Leu Thr Ser 
            20                  25                  30          


His Lys Gly Ile Leu Leu Glu Thr Glu Leu Ala Leu Thr Leu Ile Ile 
        35                  40                  45              


Phe Ile Cys Phe Thr Ala Ser Ile Ser Ala Tyr Met Ala Ala Ala Leu 
    50                  55                  60                  


Leu Glu Phe Phe Ile Thr Leu Ala Phe Leu Phe Leu Tyr Ala Thr Gln 
65                  70                  75                  80  


Tyr Tyr Gln Arg Phe Asp Arg Ile Asn Trp Pro Cys Leu Val Phe Gly 
                85                  90                  95      


Ile Ile Leu Val Ser Ile Phe Ala Tyr Asp Ala Phe Lys Ile Tyr Arg 
            100                 105                 110         


Thr Glu Met Ala Pro Gly Ala Ser Gln Gly Asp Gln Gln 
        115                 120                 125 


<210>  773
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  773

Met Pro Leu Leu Pro Ala Ala Leu Thr Ser Ser Met Leu Tyr Phe Gln 
1               5                   10                  15      


Met Val Ile Met Ala Gly Thr Val Met Leu Ala Tyr Tyr Phe Glu Tyr 
            20                  25                  30          


Thr Asp Thr Phe Thr Val Asn Val Gln Gly Phe Phe Cys His Asp Ser 
        35                  40                  45              


Ala Tyr Arg Lys Pro Tyr Pro Gly Pro Glu Asp Ser Ser Ala Val Pro 
    50                  55                  60                  


Pro Val Leu Leu Tyr Ser Leu Ala Ala Gly Val Pro Val Leu Val Ile 
65                  70                  75                  80  


Ile Val Gly Glu Thr Ala Val Phe Cys Leu Gln Leu Ala Thr Arg Asp 
                85                  90                  95      


Phe Glu Asn Gln Glu Lys Thr Ile Leu Thr Gly Asp Cys Cys Tyr Ile 
            100                 105                 110         


Asn Pro Leu Val Arg Arg Thr Val Arg Phe Leu Gly Ile Tyr Thr Phe 
        115                 120                 125             


Gly Leu Phe Ala Thr Asp Ile Phe Val Asn Ala Gly Gln Val Val Thr 
    130                 135                 140                 


Gly Asn Leu Ala Pro His Phe Leu Ala Leu Cys Lys Pro Asn Tyr Thr 
145                 150                 155                 160 


Ala Leu Gly Cys Gln Gln Tyr Thr Gln Phe Ile Ser Gly Glu Glu Ala 
                165                 170                 175     


Cys Thr Gly Asn Pro Asp Leu Ile Met Arg Ala Arg Lys Thr Phe Pro 
            180                 185                 190         


Ser Lys Glu Ala Ala Leu Ser Val Tyr Ala Ala Met Tyr Leu Thr Met 
        195                 200                 205             


Tyr Ile Thr Asn Thr Ile Lys Ala Lys Gly Thr Arg Leu Ala Lys Pro 
    210                 215                 220                 


Val Leu Cys Leu Gly Leu Met Cys Leu Ala Phe Leu Thr Gly Leu Asn 
225                 230                 235                 240 


Arg Val Ala Glu Tyr Arg Asn His Trp Ser Asp Val Ile Ala Gly Phe 
                245                 250                 255     


Leu Val Gly Ile Ser Ile Ala Val Phe Leu Val Val Cys Val Val Asn 
            260                 265                 270         


Asn Phe Lys Gly Arg Gln Ala Glu Asn Glu His Ile His Met Asp Asn 
        275                 280                 285             


Leu Ala Gln Met Pro Met Ile Ser Ile Pro Arg Val Glu Ser Pro Leu 
    290                 295                 300                 


Glu Lys Val Thr Ser Val Gln Asn His Ile Thr Ala Phe Ala Glu Val 
305                 310                 315                 320 


Thr 
    


<210>  774
<211>  736
<212>  PRT
<213>  Homo sapiens

<400>  774

Met Asn Val Ala Leu Gln Glu Leu Gly Ala Gly Ser Asn Val Gly Phe 
1               5                   10                  15      


Gln Lys Gly Thr Arg Gln Leu Leu Gly Ser Arg Thr Gln Leu Glu Leu 
            20                  25                  30          


Val Leu Ala Gly Ala Ser Leu Leu Leu Ala Ala Leu Leu Leu Gly Cys 
        35                  40                  45              


Leu Val Ala Leu Gly Val Gln Tyr His Arg Asp Pro Ser His Ser Thr 
    50                  55                  60                  


Cys Leu Thr Glu Ala Cys Ile Arg Val Ala Gly Lys Ile Leu Glu Ser 
65                  70                  75                  80  


Leu Asp Arg Gly Val Ser Pro Cys Glu Asp Phe Tyr Gln Phe Ser Cys 
                85                  90                  95      


Gly Gly Trp Ile Arg Arg Asn Pro Leu Pro Asp Gly Arg Ser Arg Trp 
            100                 105                 110         


Asn Thr Phe Asn Ser Leu Trp Asp Gln Asn Gln Ala Ile Leu Lys His 
        115                 120                 125             


Leu Leu Glu Asn Thr Thr Phe Asn Ser Ser Ser Glu Ala Glu Gln Lys 
    130                 135                 140                 


Thr Gln Arg Phe Tyr Leu Ser Cys Leu Gln Val Glu Arg Ile Glu Glu 
145                 150                 155                 160 


Leu Gly Ala Gln Pro Leu Arg Asp Leu Ile Glu Lys Ile Gly Gly Trp 
                165                 170                 175     


Asn Ile Thr Gly Pro Trp Asp Gln Asp Asn Phe Met Glu Val Leu Lys 
            180                 185                 190         


Ala Val Ala Gly Thr Tyr Arg Ala Thr Pro Phe Phe Thr Val Tyr Ile 
        195                 200                 205             


Ser Ala Asp Ser Lys Ser Ser Asn Ser Asn Val Ile Gln Val Asp Gln 
    210                 215                 220                 


Ser Gly Leu Phe Leu Pro Ser Arg Asp Tyr Tyr Leu Asn Arg Thr Ala 
225                 230                 235                 240 


Asn Glu Lys Val Leu Thr Ala Tyr Leu Asp Tyr Met Glu Glu Leu Gly 
                245                 250                 255     


Met Leu Leu Gly Gly Arg Pro Thr Ser Thr Arg Glu Gln Met Gln Gln 
            260                 265                 270         


Val Leu Glu Leu Glu Ile Gln Leu Ala Asn Ile Thr Val Pro Gln Asp 
        275                 280                 285             


Gln Arg Arg Asp Glu Glu Lys Ile Tyr His Lys Met Ser Ile Ser Glu 
    290                 295                 300                 


Leu Gln Ala Leu Ala Pro Ser Met Asp Trp Leu Glu Phe Leu Ser Phe 
305                 310                 315                 320 


Leu Leu Ser Pro Leu Glu Leu Ser Asp Ser Glu Pro Val Val Val Tyr 
                325                 330                 335     


Gly Met Asp Tyr Leu Gln Gln Val Ser Glu Leu Ile Asn Arg Thr Glu 
            340                 345                 350         


Pro Ser Ile Leu Asn Asn Tyr Leu Ile Trp Asn Leu Val Gln Lys Thr 
        355                 360                 365             


Thr Ser Ser Leu Asp Arg Arg Phe Glu Ser Ala Gln Glu Lys Leu Leu 
    370                 375                 380                 


Glu Thr Leu Tyr Gly Thr Lys Lys Ser Cys Val Pro Arg Trp Gln Thr 
385                 390                 395                 400 


Cys Ile Ser Asn Thr Asp Asp Ala Leu Gly Phe Ala Leu Gly Ser Leu 
                405                 410                 415     


Phe Val Lys Ala Thr Phe Asp Arg Gln Ser Lys Glu Ile Ala Glu Gly 
            420                 425                 430         


Met Ile Ser Glu Ile Arg Thr Ala Phe Glu Glu Ala Leu Gly Gln Leu 
        435                 440                 445             


Val Trp Met Asp Glu Lys Thr Arg Gln Ala Ala Lys Glu Lys Ala Asp 
    450                 455                 460                 


Ala Ile Tyr Asp Met Ile Gly Phe Pro Asp Phe Ile Leu Glu Pro Lys 
465                 470                 475                 480 


Glu Leu Asp Asp Val Tyr Asp Gly Tyr Glu Ile Ser Glu Asp Ser Phe 
                485                 490                 495     


Phe Gln Asn Met Leu Asn Leu Tyr Asn Phe Ser Ala Lys Val Met Ala 
            500                 505                 510         


Asp Gln Leu Arg Lys Pro Pro Ser Arg Asp Gln Trp Ser Met Thr Pro 
        515                 520                 525             


Gln Thr Val Asn Ala Tyr Tyr Leu Pro Thr Lys Asn Glu Ile Val Phe 
    530                 535                 540                 


Pro Ala Gly Ile Leu Gln Ala Pro Phe Tyr Ala Arg Asn His Pro Lys 
545                 550                 555                 560 


Ala Leu Asn Phe Gly Gly Ile Gly Val Val Met Gly His Glu Leu Thr 
                565                 570                 575     


His Ala Phe Asp Asp Gln Gly Arg Glu Tyr Asp Lys Glu Gly Asn Leu 
            580                 585                 590         


Arg Pro Trp Trp Gln Asn Glu Ser Leu Ala Ala Phe Arg Asn His Thr 
        595                 600                 605             


Ala Cys Met Glu Glu Gln Tyr Asn Gln Tyr Gln Val Asn Gly Glu Arg 
    610                 615                 620                 


Leu Asn Gly Arg Gln Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly 
625                 630                 635                 640 


Leu Lys Ala Ala Tyr Asn Ala Tyr Lys Ala Trp Leu Arg Lys His Gly 
                645                 650                 655     


Glu Glu Gln Gln Leu Pro Ala Val Gly Leu Thr Asn His Gln Leu Phe 
            660                 665                 670         


Phe Val Gly Phe Ala Gln Val Trp Cys Ser Val Arg Thr Pro Glu Ser 
        675                 680                 685             


Ser His Glu Gly Leu Val Thr Asp Pro His Ser Pro Ala Arg Phe Arg 
    690                 695                 700                 


Val Leu Gly Thr Leu Ser Asn Ser Arg Asp Phe Leu Arg His Phe Gly 
705                 710                 715                 720 


Cys Pro Val Gly Ser Pro Met Asn Pro Gly Gln Leu Cys Glu Val Trp 
                725                 730                 735     


<210>  775
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  775

Met Ser Gln Asp Thr Lys Val Lys Thr Thr Glu Ser Ser Pro Pro Ala 
1               5                   10                  15      


Pro Ser Lys Ala Arg Lys Leu Leu Pro Val Leu Asp Pro Ser Gly Asp 
            20                  25                  30          


Tyr Tyr Tyr Trp Trp Leu Asn Thr Met Val Phe Pro Val Met Tyr Asn 
        35                  40                  45              


Leu Ile Ile Leu Val Cys Arg Ala Cys Phe Pro Asp Leu Gln His Gly 
    50                  55                  60                  


Tyr Leu Val Ala Trp Leu Val Leu Asp Tyr Thr Ser Asp Leu Leu Tyr 
65                  70                  75                  80  


Leu Leu Asp Met Val Val Arg Phe His Thr Gly Phe Leu Glu Gln Gly 
                85                  90                  95      


Ile Leu Val Val Asp Lys Gly Arg Ile Ser Ser Arg Tyr Val Arg Thr 
            100                 105                 110         


Trp Ser Phe Phe Leu Asp Leu Ala Ser Leu Met Pro Thr Asp Val Val 
        115                 120                 125             


Tyr Val Arg Leu Gly Pro His Thr Pro Thr Leu Arg Leu Asn Arg Phe 
    130                 135                 140                 


Leu Arg Ala Pro Arg Leu Phe Glu Ala Phe Asp Arg Thr Glu Thr Arg 
145                 150                 155                 160 


Thr Ala Tyr Pro Asn Ala Phe Arg Ile Ala Lys Leu Met Leu Tyr Ile 
                165                 170                 175     


Phe Val Val Ile His Trp Asn Ser Cys Leu Tyr Phe Ala Leu Ser Arg 
            180                 185                 190         


Tyr Leu Gly Phe Gly Arg Asp Ala Trp Val Tyr Pro Asp Pro Ala Gln 
        195                 200                 205             


Pro Gly Phe Glu Arg Leu Arg Arg Gln Tyr Leu Tyr Ser Phe Tyr Phe 
    210                 215                 220                 


Ser Thr Leu Ile Leu Thr Thr Val Gly Asp Thr Pro Pro Pro Ala Arg 
225                 230                 235                 240 


Glu Glu Glu Tyr Leu Phe Met Val Gly Asp Phe Leu Leu Ala Val Met 
                245                 250                 255     


Gly Phe Ala Thr Ile Met Gly Ser Met Ser Ser Val Ile Tyr Asn Met 
            260                 265                 270         


Asn Thr Ala Asp Ala Ala Phe Tyr Pro Asp His Ala Leu Val Lys Lys 
        275                 280                 285             


Tyr Met Lys Leu Gln His Val Asn Arg Lys Leu Glu Arg Arg Val Ile 
    290                 295                 300                 


Asp Trp Tyr Gln His Leu Gln Ile Asn Lys Lys Met Thr Asn Glu Val 
305                 310                 315                 320 


Ala Ile Leu Gln His Leu Pro Glu Arg Leu Arg Ala Glu Val Ala Val 
                325                 330                 335     


Ser Val His Leu Ser Thr Leu Ser Arg Val Gln Ile Phe Gln Asn Cys 
            340                 345                 350         


Glu Ala Ser Leu Leu Glu Glu Leu Val Leu Lys Leu Gln Pro Gln Thr 
        355                 360                 365             


Tyr Ser Pro Gly Glu Tyr Val Cys Arg Lys Gly Asp Ile Gly Gln Glu 
    370                 375                 380                 


Met Tyr Ile Ile Arg Glu Gly Gln Leu Ala Val Val Ala Asp Asp Gly 
385                 390                 395                 400 


Ile Thr Gln Tyr Ala Val Leu Gly Ala Gly Leu Tyr Phe Gly Glu Ile 
                405                 410                 415     


Ser Ile Ile Asn Ile Lys Gly Asn Met Ser Gly Asn Arg Arg Thr Ala 
            420                 425                 430         


Asn Ile Lys Ser Leu Gly Tyr Ser Asp Leu Phe Cys Leu Ser Lys Glu 
        435                 440                 445             


Asp Leu Arg Glu Val Leu Ser Glu Tyr Pro Gln Ala Gln Thr Ile Met 
    450                 455                 460                 


Glu Glu Lys Gly Arg Glu Ile Leu Leu Lys Met Asn Lys Leu Asp Val 
465                 470                 475                 480 


Asn Ala Glu Ala Ala Glu Ile Ala Leu Gln Glu Ala Thr Glu Ser Arg 
                485                 490                 495     


Leu Arg Gly Leu Asp Gln Gln Leu Asp Asp Leu Gln Thr Lys Phe Ala 
            500                 505                 510         


Arg Leu Leu Ala Glu Leu Glu Ser Ser Ala Leu Lys Ile Ala Tyr Arg 
        515                 520                 525             


Ile Glu Arg Leu Glu Trp Gln Thr Arg Glu Trp Pro Met Pro Glu Asp 
    530                 535                 540                 


Leu Ala Glu Ala Asp Asp Glu Gly Glu Pro Glu Glu Gly Thr Ser Lys 
545                 550                 555                 560 


Asp Glu Glu Gly Arg Ala Ser Gln Glu Gly Pro Pro Gly Pro Glu 
                565                 570                 575 


<210>  776
<211>  685
<212>  PRT
<213>  Homo sapiens

<400>  776

Met Ala Glu Trp Leu Leu Ser Ala Ser Trp Gln Arg Arg Ala Lys Ala 
1               5                   10                  15      


Met Thr Ala Ala Ala Gly Ser Ala Gly Arg Ala Ala Val Pro Leu Leu 
            20                  25                  30          


Leu Cys Ala Leu Leu Ala Pro Gly Gly Ala Tyr Val Leu Asp Asp Ser 
        35                  40                  45              


Asp Gly Leu Gly Arg Glu Phe Asp Gly Ile Gly Ala Val Ser Gly Gly 
    50                  55                  60                  


Gly Ala Thr Ser Arg Leu Leu Val Asn Tyr Pro Glu Pro Tyr Arg Ser 
65                  70                  75                  80  


Gln Ile Leu Asp Tyr Leu Phe Lys Pro Asn Phe Gly Ala Ser Leu His 
                85                  90                  95      


Ile Leu Lys Val Glu Ile Gly Gly Asp Gly Gln Thr Thr Asp Gly Thr 
            100                 105                 110         


Glu Pro Ser His Met His Tyr Ala Leu Asp Glu Asn Tyr Phe Arg Gly 
        115                 120                 125             


Tyr Glu Trp Trp Leu Met Lys Glu Ala Lys Lys Arg Asn Pro Asn Ile 
    130                 135                 140                 


Thr Leu Ile Gly Leu Pro Trp Ser Phe Pro Gly Trp Leu Gly Lys Gly 
145                 150                 155                 160 


Phe Asp Trp Pro Tyr Val Asn Leu Gln Leu Thr Ala Tyr Tyr Val Val 
                165                 170                 175     


Thr Trp Ile Val Gly Ala Lys Arg Tyr His Asp Leu Asp Ile Asp Tyr 
            180                 185                 190         


Ile Gly Ile Trp Asn Glu Arg Ser Tyr Asn Ala Asn Tyr Ile Lys Ile 
        195                 200                 205             


Leu Arg Lys Met Leu Asn Tyr Gln Gly Leu Gln Arg Val Lys Ile Ile 
    210                 215                 220                 


Ala Ser Asp Asn Leu Trp Glu Ser Ile Ser Ala Ser Met Leu Leu Asp 
225                 230                 235                 240 


Ala Glu Leu Phe Lys Val Val Asp Val Ile Gly Ala His Tyr Pro Gly 
                245                 250                 255     


Thr His Ser Ala Lys Asp Ala Lys Leu Thr Gly Lys Lys Leu Trp Ser 
            260                 265                 270         


Ser Glu Asp Phe Ser Thr Leu Asn Ser Asp Met Gly Ala Gly Cys Trp 
        275                 280                 285             


Gly Arg Ile Leu Asn Gln Asn Tyr Ile Asn Gly Tyr Met Thr Ser Thr 
    290                 295                 300                 


Ile Ala Trp Asn Leu Val Ala Ser Tyr Tyr Glu Gln Leu Pro Tyr Gly 
305                 310                 315                 320 


Arg Cys Gly Leu Met Thr Ala Gln Glu Pro Trp Ser Gly His Tyr Val 
                325                 330                 335     


Val Glu Ser Pro Val Trp Val Ser Ala His Thr Thr Gln Phe Thr Gln 
            340                 345                 350         


Pro Gly Trp Tyr Tyr Leu Lys Thr Val Gly His Leu Glu Lys Gly Gly 
        355                 360                 365             


Ser Tyr Val Ala Leu Thr Asp Gly Leu Gly Asn Leu Thr Ile Ile Ile 
    370                 375                 380                 


Glu Thr Met Ser His Lys His Ser Lys Cys Ile Arg Pro Phe Leu Pro 
385                 390                 395                 400 


Tyr Phe Asn Val Ser Gln Gln Phe Ala Thr Phe Val Leu Lys Gly Ser 
                405                 410                 415     


Phe Ser Glu Ile Pro Glu Leu Gln Val Trp Tyr Thr Lys Leu Gly Lys 
            420                 425                 430         


Thr Ser Glu Arg Phe Leu Phe Lys Gln Leu Asp Ser Leu Trp Leu Leu 
        435                 440                 445             


Asp Ser Asp Gly Ser Phe Thr Leu Ser Leu His Glu Asp Glu Leu Phe 
    450                 455                 460                 


Thr Leu Thr Thr Leu Thr Thr Gly Arg Lys Gly Ser Tyr Pro Leu Pro 
465                 470                 475                 480 


Pro Lys Ser Gln Pro Phe Pro Ser Thr Tyr Lys Asp Asp Phe Asn Val 
                485                 490                 495     


Asp Tyr Pro Phe Phe Ser Glu Ala Pro Asn Phe Ala Asp Gln Thr Gly 
            500                 505                 510         


Val Phe Glu Tyr Phe Thr Asn Ile Glu Asp Pro Gly Glu His His Phe 
        515                 520                 525             


Thr Leu Arg Gln Val Leu Asn Gln Arg Pro Ile Thr Trp Ala Ala Asp 
    530                 535                 540                 


Ala Ser Asn Thr Ile Ser Ile Ile Gly Asp Tyr Asn Trp Thr Asn Leu 
545                 550                 555                 560 


Thr Ile Lys Cys Asp Val Tyr Ile Glu Thr Pro Asp Thr Gly Gly Val 
                565                 570                 575     


Phe Ile Ala Gly Arg Val Asn Lys Gly Gly Ile Leu Ile Arg Ser Ala 
            580                 585                 590         


Arg Gly Ile Phe Phe Trp Ile Phe Ala Asn Gly Ser Tyr Arg Val Thr 
        595                 600                 605             


Gly Asp Leu Ala Gly Trp Ile Ile Tyr Ala Leu Gly Arg Val Glu Val 
    610                 615                 620                 


Thr Ala Lys Lys Trp Tyr Thr Leu Thr Leu Thr Ile Lys Gly His Phe 
625                 630                 635                 640 


Thr Ser Gly Met Leu Asn Asp Lys Ser Leu Trp Thr Asp Ile Pro Val 
                645                 650                 655     


Asn Phe Pro Lys Asn Gly Trp Ala Ala Ile Gly Thr His Ser Phe Glu 
            660                 665                 670         


Phe Ala Gln Phe Asp Asn Phe Leu Val Glu Ala Thr Arg 
        675                 680                 685 


<210>  777
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  777

Met Gly Leu Leu Ala Phe Leu Lys Thr Gln Phe Val Leu His Leu Leu 
1               5                   10                  15      


Val Gly Phe Val Phe Val Val Ser Gly Leu Val Ile Asn Phe Val Gln 
            20                  25                  30          


Leu Cys Thr Leu Ala Leu Trp Pro Val Ser Lys Gln Leu Tyr Arg Arg 
        35                  40                  45              


Leu Asn Cys Arg Leu Ala Tyr Ser Leu Trp Ser Gln Leu Val Met Leu 
    50                  55                  60                  


Leu Glu Trp Trp Ser Cys Thr Glu Cys Thr Leu Phe Thr Asp Gln Ala 
65                  70                  75                  80  


Thr Val Glu Arg Phe Gly Lys Glu His Ala Val Ile Ile Leu Asn His 
                85                  90                  95      


Asn Phe Glu Ile Asp Phe Leu Cys Gly Trp Thr Met Cys Glu Arg Phe 
            100                 105                 110         


Gly Val Leu Gly Ser Ser Lys Val Leu Ala Lys Lys Glu Leu Leu Tyr 
        115                 120                 125             


Val Pro Leu Ile Gly Trp Thr Trp Tyr Phe Leu Glu Ile Val Phe Cys 
    130                 135                 140                 


Lys Arg Lys Trp Glu Glu Asp Arg Asp Thr Val Val Glu Gly Leu Arg 
145                 150                 155                 160 


Arg Leu Ser Asp Tyr Pro Glu Tyr Met Trp Phe Leu Leu Tyr Cys Glu 
                165                 170                 175     


Gly Thr Arg Phe Thr Glu Thr Lys His Arg Val Ser Met Glu Val Ala 
            180                 185                 190         


Ala Ala Lys Gly Leu Pro Val Leu Lys Tyr His Leu Leu Pro Arg Thr 
        195                 200                 205             


Lys Gly Phe Thr Thr Ala Val Lys Cys Leu Arg Gly Thr Val Ala Ala 
    210                 215                 220                 


Val Tyr Asp Val Thr Leu Asn Phe Arg Gly Asn Lys Asn Pro Ser Leu 
225                 230                 235                 240 


Leu Gly Ile Leu Tyr Gly Lys Lys Tyr Glu Ala Asp Met Cys Val Arg 
                245                 250                 255     


Arg Phe Pro Leu Glu Asp Ile Pro Leu Asp Glu Lys Glu Ala Ala Gln 
            260                 265                 270         


Trp Leu His Lys Leu Tyr Gln Glu Lys Asp Ala Leu Gln Glu Ile Tyr 
        275                 280                 285             


Asn Gln Lys Gly Met Phe Pro Gly Glu Gln Phe Lys Pro Ala Arg Arg 
    290                 295                 300                 


Pro Trp Thr Leu Leu Asn Phe Leu Ser Trp Ala Thr Ile Leu Leu Ser 
305                 310                 315                 320 


Pro Leu Phe Ser Phe Val Leu Gly Val Phe Ala Ser Gly Ser Pro Leu 
                325                 330                 335     


Leu Ile Leu Thr Phe Leu Gly Phe Val Gly Ala Ala Ser Phe Gly Val 
            340                 345                 350         


Arg Arg Leu Ile Gly Val Thr Glu Ile Glu Lys Gly Ser Ser Tyr Gly 
        355                 360                 365             


Asn Gln Glu Phe Lys Lys Lys Glu 
    370                 375     


<210>  778
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  778

Met Gly Asn Trp Gly Leu Gly Ile Ala Pro Trp Val Asp Gly Glu Ser 
1               5                   10                  15      


Glu Leu Glu Phe Arg Arg Leu Gly Met Gln Gly Pro Leu Glu Ala Leu 
            20                  25                  30          


Arg Arg Arg Glu Trp Asn Thr Gln Arg Ala Ser Phe Ser Phe Ser Phe 
        35                  40                  45              


Leu Ile Ala Leu Ser Pro His Thr Val Asp Tyr Cys His Ser Tyr Glu 
    50                  55                  60                  


Leu Phe Asn Arg Arg Trp His Gly His Val Leu Ala Thr Gln Arg Pro 
65                  70                  75                  80  


Ser Leu Phe Ile Leu Met Leu Val 
                85              


<210>  779
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  779

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Ala Lys Glu Lys Lys Pro Ser Tyr 
145                 150                 155                 160 


Asn Arg Gly Leu Cys Glu Asn Ala Pro Asn Arg Ala Arg Met 
                165                 170                 


<210>  780
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  780

Met Ala Trp Arg Gly Trp Ala Gln Arg Gly Trp Gly Cys Gly Gln Ala 
1               5                   10                  15      


Trp Gly Ala Ser Val Gly Gly Arg Ser Cys Glu Glu Leu Thr Ala Val 
            20                  25                  30          


Leu Thr Pro Pro Gln Leu Leu Gly Arg Arg Phe Asn Phe Phe Ile Gln 
        35                  40                  45              


Gln Lys Cys Gly Phe Arg Lys Ala Pro Arg Lys Val Glu Pro Arg Arg 
    50                  55                  60                  


Ser Asp Pro Gly Thr Ser Gly Glu Ala Tyr Lys Arg Ser Ala Leu Ile 
65                  70                  75                  80  


Pro Pro Val Glu Glu Thr Val Phe Tyr Pro Ser Pro Tyr Pro Ile Arg 
                85                  90                  95      


Ser Leu Ile Lys Pro Leu Phe Phe Thr Val Gly Phe Thr Gly Cys Ala 
            100                 105                 110         


Phe Gly Ser Ala Ala Ile Trp Gln Tyr Glu Ser Leu Lys Ser Arg Val 
        115                 120                 125             


Gln Ser Tyr Phe Asp Gly Ile Lys Ala Asp Trp Leu Asp Ser Ile Arg 
    130                 135                 140                 


Pro Gln Lys Glu Gly Asp Phe Arg Lys Glu Ile Asn Lys Trp Trp Asn 
145                 150                 155                 160 


Asn Leu Ser Asp Gly Gln Arg Thr Val Thr Gly Ile Ile Ala Ala Asn 
                165                 170                 175     


Val Leu Val Phe Cys Leu Trp Arg Val Pro Ser Leu Gln Arg Thr Met 
            180                 185                 190         


Ile Arg Tyr Phe Thr Ser Asn Pro Ala Ser Ser Val Ile Ser Asn Phe 
        195                 200                 205             


Val Ser Tyr Val Gly Lys Val Ala Thr Gly Arg Tyr Gly Pro Ser Leu 
    210                 215                 220                 


Gly Ala Ser Gly Ala Ile Met Thr Val Leu Ala Ala Val Cys Thr Lys 
225                 230                 235                 240 


Ile Pro Glu Gly Arg Leu Ala Ile Ile Phe Leu Pro Met Phe Thr Phe 
                245                 250                 255     


Thr Ala Gly Asn Ala Leu Lys Ala Ile Ile Ala Met Asp Thr Ala Gly 
            260                 265                 270         


Met Ile Leu Gly Trp Lys Phe Phe Asp His Ala Ala His Leu Gly Gly 
        275                 280                 285             


Ala Leu Phe Gly Ile Trp Tyr Val Thr Tyr Gly His Glu Leu Ile Trp 
    290                 295                 300                 


Lys Asn Arg Glu Pro Leu Val Lys Ile Trp His Glu Ile Arg Thr Asn 
305                 310                 315                 320 


Gly Pro Lys Lys Gly Gly Gly Ser Lys 
                325                 


<210>  781
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  781

Met Pro Ser Gly Phe Gln Gln Ile Gly Ser Glu Asp Gly Glu Pro Pro 
1               5                   10                  15      


Gln Gln Arg Val Thr Gly Thr Leu Val Leu Ala Val Phe Ser Ala Val 
            20                  25                  30          


Leu Gly Ser Leu Gln Phe Gly Tyr Asn Ile Gly Val Ile Asn Ala Pro 
        35                  40                  45              


Gln Lys Val Ile Glu Gln Ser Tyr Asn Glu Thr Trp Leu Gly Arg Gln 
    50                  55                  60                  


Gly Pro Glu Gly Pro Ser Ser Ile Pro Pro Gly Thr Leu Thr Thr Leu 
65                  70                  75                  80  


Trp Ala Leu Ser Val Ala Ile Phe Ser Val Gly Gly Met Ile Ser Ser 
                85                  90                  95      


Phe Leu Ile Gly Ile Ile Ser Gln Trp Leu Gly Arg Lys Arg Ala Met 
            100                 105                 110         


Leu Val Asn Asn Val Leu Ala Val Leu Gly Gly Ser Leu Met Gly Leu 
        115                 120                 125             


Ala Asn Ala Ala Ala Ser Tyr Glu Met Leu Ile Leu Gly Arg Phe Leu 
    130                 135                 140                 


Ile Gly Ala Tyr Ser Gly Leu Thr Ser Gly Leu Val Pro Met Tyr Val 
145                 150                 155                 160 


Gly Glu Ile Ala Pro Thr His Leu Arg Gly Ala Leu Gly Thr Leu Asn 
                165                 170                 175     


Gln Leu Ala Ile Val Ile Gly Ile Leu Ile Ala Gln Val Leu Gly Leu 
            180                 185                 190         


Glu Ser Leu Leu Gly Thr Ala Ser Leu Trp Pro Leu Leu Leu Gly Leu 
        195                 200                 205             


Thr Val Leu Pro Ala Leu Leu Gln Leu Val Leu Leu Pro Phe Cys Pro 
    210                 215                 220                 


Glu Ser Pro Arg Tyr Leu Tyr Ile Ile Gln Asn Leu Glu Gly Pro Ala 
225                 230                 235                 240 


Arg Lys Ser Leu Lys Arg Leu Thr Gly Trp Ala Asp Val Ser Gly Val 
                245                 250                 255     


Leu Ala Glu Leu Lys Asp Glu Lys Arg Lys Leu Glu Arg Glu Arg Pro 
            260                 265                 270         


Leu Ser Leu Leu Gln Leu Leu Gly Ser Arg Thr His Arg Gln Pro Leu 
        275                 280                 285             


Ile Ile Ala Val Val Leu Gln Leu Ser Gln Gln Leu Ser Gly Ile Asn 
    290                 295                 300                 


Ala Val Phe Tyr Tyr Ser Thr Ser Ile Phe Glu Thr Ala Gly Val Gly 
305                 310                 315                 320 


Gln Pro Ala Tyr Ala Thr Ile Gly Ala Gly Val Val Asn Thr Val Phe 
                325                 330                 335     


Thr Leu Val Ser Val Leu Leu Val Glu Arg Ala Gly Arg Arg Thr Leu 
            340                 345                 350         


His Leu Leu Gly Leu Ala Gly Met Cys Gly Cys Ala Ile Leu Met Thr 
        355                 360                 365             


Val Ala Leu Leu Leu Leu Glu Arg Val Pro Ala Met Ser Tyr Val Ser 
    370                 375                 380                 


Ile Val Ala Ile Phe Gly Phe Val Ala Phe Phe Glu Ile Gly Pro Gly 
385                 390                 395                 400 


Pro Ile Pro Trp Phe Ile Val Ala Glu Leu Phe Ser Gln Gly Pro Arg 
                405                 410                 415     


Pro Ala Ala Met Ala Val Ala Gly Phe Ser Asn Trp Thr Ser Asn Phe 
            420                 425                 430         


Ile Ile Gly Met Gly Phe Gln Tyr Val Ala Glu Ala Met Gly Pro Tyr 
        435                 440                 445             


Val Phe Leu Leu Phe Ala Val Leu Leu Leu Gly Phe Phe Ile Phe Thr 
    450                 455                 460                 


Phe Leu Arg Val Pro Glu Thr Arg Gly Arg Thr Phe Asp Gln Ile Ser 
465                 470                 475                 480 


Ala Ala Phe His Arg Thr Pro Ser Leu Leu Glu Gln Glu Val Lys Pro 
                485                 490                 495     


Ser Thr Glu Leu Glu Tyr Leu Gly Pro Asp Glu Asn Asp 
            500                 505                 


<210>  782
<211>  1119
<212>  PRT
<213>  Homo sapiens

<400>  782

Met Thr Ala Ala Ala Ala Ser Asn Trp Gly Leu Ile Thr Asn Ile Val 
1               5                   10                  15      


Asn Ser Ile Val Gly Val Ser Val Leu Thr Met Pro Phe Cys Phe Lys 
            20                  25                  30          


Gln Cys Gly Ile Val Leu Gly Ala Leu Leu Leu Val Phe Cys Ser Trp 
        35                  40                  45              


Met Thr His Gln Ser Cys Met Phe Leu Val Lys Ser Ala Ser Leu Ser 
    50                  55                  60                  


Lys Arg Arg Thr Tyr Ala Gly Leu Ala Phe His Ala Tyr Gly Lys Ala 
65                  70                  75                  80  


Gly Lys Met Leu Val Glu Thr Ser Met Ile Gly Leu Met Leu Gly Thr 
                85                  90                  95      


Cys Ile Ala Phe Tyr Val Val Ile Gly Asp Leu Gly Ser Asn Phe Phe 
            100                 105                 110         


Ala Arg Leu Phe Gly Phe Gln Val Gly Gly Thr Phe Arg Met Phe Leu 
        115                 120                 125             


Leu Phe Ala Val Ser Leu Cys Ile Val Leu Pro Leu Ser Leu Gln Arg 
    130                 135                 140                 


Asn Met Met Ala Ser Ile Gln Ser Phe Ser Ala Met Ala Leu Leu Phe 
145                 150                 155                 160 


Tyr Thr Val Phe Met Phe Val Ile Val Leu Ser Ser Leu Lys His Gly 
                165                 170                 175     


Leu Phe Ser Gly Gln Trp Leu Arg Arg Val Ser Tyr Val Arg Trp Glu 
            180                 185                 190         


Gly Val Phe Arg Cys Ile Pro Ile Phe Gly Met Ser Phe Ala Cys Gln 
        195                 200                 205             


Ser Gln Val Leu Pro Thr Tyr Asp Ser Leu Asp Glu Pro Ser Val Lys 
    210                 215                 220                 


Thr Met Ser Ser Ile Phe Ala Ser Ser Leu Asn Val Val Thr Thr Phe 
225                 230                 235                 240 


Tyr Val Met Val Gly Phe Phe Gly Tyr Val Ser Phe Thr Glu Ala Thr 
                245                 250                 255     


Ala Gly Asn Val Leu Met His Phe Pro Ser Asn Leu Val Thr Glu Met 
            260                 265                 270         


Leu Arg Val Gly Phe Met Met Ser Val Ala Val Gly Phe Pro Met Met 
        275                 280                 285             


Ile Leu Pro Cys Arg Gln Ala Leu Ser Thr Leu Leu Cys Glu Gln Gln 
    290                 295                 300                 


Gln Lys Asp Gly Thr Phe Ala Ala Gly Gly Tyr Met Pro Pro Leu Arg 
305                 310                 315                 320 


Phe Lys Ala Leu Thr Leu Ser Val Val Phe Gly Thr Met Val Gly Gly 
                325                 330                 335     


Ile Leu Ile Pro Asn Val Glu Thr Ile Leu Gly Leu Thr Gly Ala Thr 
            340                 345                 350         


Met Gly Ser Leu Ile Cys Phe Ile Cys Pro Ala Leu Ile Tyr Lys Lys 
        355                 360                 365             


Ile His Lys Asn Ala Leu Ser Ser Gln Val Val Leu Trp Val Gly Leu 
    370                 375                 380                 


Gly Val Leu Val Val Ser Thr Val Thr Thr Leu Ser Val Ser Glu Glu 
385                 390                 395                 400 


Val Pro Glu Asp Leu Ala Glu Glu Ala Pro Gly Gly Arg Leu Gly Glu 
                405                 410                 415     


Ala Glu Gly Leu Met Lys Val Glu Ala Ala Arg Leu Ser Ala Gln Asp 
            420                 425                 430         


Pro Val Val Ala Val Ala Glu Asp Gly Arg Glu Lys Pro Lys Leu Pro 
        435                 440                 445             


Lys Glu Arg Glu Glu Leu Glu Gln Ala Gln Ile Lys Gly Pro Val Asp 
    450                 455                 460                 


Val Pro Gly Arg Glu Asp Gly Lys Glu Ala Pro Glu Glu Ala Gln Leu 
465                 470                 475                 480 


Asp Arg Pro Gly Gln Gly Ile Ala Val Pro Val Gly Glu Ala His Arg 
                485                 490                 495     


His Glu Pro Pro Val Pro His Asp Lys Val Val Val Asp Glu Gly Gln 
            500                 505                 510         


Asp Arg Glu Val Pro Glu Glu Asn Lys Pro Pro Ser Arg His Ala Gly 
        515                 520                 525             


Gly Lys Ala Pro Gly Val Gln Gly Gln Met Ala Pro Pro Leu Pro Asp 
    530                 535                 540                 


Ser Glu Arg Glu Lys Gln Glu Pro Glu Gln Gly Glu Val Gly Lys Arg 
545                 550                 555                 560 


Pro Gly Gln Ala Gln Ala Leu Glu Glu Ala Gly Asp Leu Pro Glu Asp 
                565                 570                 575     


Pro Gln Lys Val Pro Glu Ala Asp Gly Gln Pro Ala Val Gln Pro Ala 
            580                 585                 590         


Lys Glu Asp Leu Gly Pro Gly Asp Arg Gly Leu His Pro Arg Pro Gln 
        595                 600                 605             


Ala Val Leu Ser Glu Gln Gln Asn Gly Leu Ala Val Gly Gly Gly Glu 
    610                 615                 620                 


Lys Ala Lys Gly Gly Pro Pro Pro Gly Asn Ala Ala Gly Asp Thr Gly 
625                 630                 635                 640 


Gln Pro Ala Glu Asp Ser Asp His Gly Gly Lys Pro Pro Leu Pro Ala 
                645                 650                 655     


Glu Lys Pro Ala Pro Gly Pro Gly Leu Pro Pro Glu Pro Arg Glu Gln 
            660                 665                 670         


Arg Asp Val Glu Arg Ala Gly Gly Asn Gln Ala Ala Ser Gln Leu Glu 
        675                 680                 685             


Glu Ala Gly Arg Ala Glu Met Leu Asp His Ala Val Leu Leu Gln Val 
    690                 695                 700                 


Ile Lys Glu Gln Gln Val Gln Gln Lys Arg Leu Leu Asp Gln Gln Glu 
705                 710                 715                 720 


Lys Leu Leu Ala Val Ile Glu Glu Gln His Lys Glu Ile His Gln Gln 
                725                 730                 735     


Arg Gln Glu Asp Glu Glu Asp Lys Pro Arg Gln Val Glu Val His Gln 
            740                 745                 750         


Glu Pro Gly Ala Ala Val Pro Arg Gly Gln Glu Ala Pro Glu Gly Lys 
        755                 760                 765             


Ala Arg Glu Thr Val Glu Asn Leu Pro Pro Leu Pro Leu Asp Pro Val 
    770                 775                 780                 


Leu Arg Ala Pro Gly Gly Arg Pro Ala Pro Ser Gln Asp Leu Asn Gln 
785                 790                 795                 800 


Arg Ser Leu Glu His Ser Glu Gly Pro Val Gly Arg Asp Pro Ala Gly 
                805                 810                 815     


Pro Pro Asp Gly Gly Pro Asp Thr Glu Pro Arg Ala Ala Gln Ala Lys 
            820                 825                 830         


Leu Arg Asp Gly Gln Lys Asp Ala Ala Pro Arg Ala Ala Gly Thr Val 
        835                 840                 845             


Lys Glu Leu Pro Lys Gly Pro Glu Gln Val Pro Val Pro Asp Pro Ala 
    850                 855                 860                 


Arg Glu Ala Gly Gly Pro Glu Glu Arg Leu Ala Glu Glu Phe Pro Gly 
865                 870                 875                 880 


Gln Ser Gln Asp Val Thr Gly Gly Ser Gln Asp Arg Lys Lys Pro Gly 
                885                 890                 895     


Lys Glu Val Ala Ala Thr Gly Thr Ser Ile Leu Lys Glu Ala Asn Trp 
            900                 905                 910         


Leu Val Ala Gly Pro Gly Ala Glu Thr Gly Asp Pro Arg Met Lys Pro 
        915                 920                 925             


Lys Gln Val Ser Arg Asp Leu Gly Leu Ala Ala Asp Leu Pro Gly Gly 
    930                 935                 940                 


Ala Glu Gly Ala Ala Ala Gln Pro Gln Ala Val Leu Arg Gln Pro Glu 
945                 950                 955                 960 


Leu Arg Val Ile Ser Asp Gly Glu Gln Gly Gly Gln Gln Gly His Arg 
                965                 970                 975     


Leu Asp His Gly Gly His Leu Glu Met Arg Lys Ala Arg Gly Gly Asp 
            980                 985                 990         


His Val Pro Val Ser His Glu Gln  Pro Arg Gly Gly Glu  Asp Ala Ala 
        995                 1000                 1005             


Val Gln  Glu Pro Arg Gln Arg  Pro Glu Pro Glu Leu  Gly Leu Lys 
    1010                 1015                 1020             


Arg Ala  Val Pro Gly Gly Gln  Arg Pro Asp Asn Ala  Lys Pro Asn 
    1025                 1030                 1035             


Arg Asp  Leu Lys Leu Gln Ala  Gly Ser Asp Leu Arg  Arg Arg Arg 
    1040                 1045                 1050             


Arg Asp  Leu Gly Pro His Ala  Glu Gly Gln Leu Ala  Pro Arg Asp 
    1055                 1060                 1065             


Gly Val  Ile Ile Gly Leu Asn  Pro Leu Pro Asp Val  Gln Val Asn 
    1070                 1075                 1080             


Asp Leu  Arg Gly Ala Leu Asp  Ala Gln Leu Arg Gln  Ala Ala Gly 
    1085                 1090                 1095             


Gly Ala  Leu Gln Val Val His  Ser Arg Gln Leu Arg  Gln Ala Pro 
    1100                 1105                 1110             


Gly Pro  Pro Glu Glu Ser 
    1115                 


<210>  783
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  783

Met Ser Asn Asp Gly Arg Ser Arg Asn Arg Asp Arg Arg Tyr Asp Glu 
1               5                   10                  15      


Val Pro Ser Asp Leu Pro Tyr Gln Asp Thr Thr Ile Arg Thr His Pro 
            20                  25                  30          


Thr Leu His Asp Ser Glu Arg Ala Val Ser Ala Asp Pro Leu Pro Pro 
        35                  40                  45              


Pro Pro Leu Pro Leu Gln Pro Pro Phe Gly Pro Asp Phe Tyr Ser Ser 
    50                  55                  60                  


Asp Thr Glu Glu Pro Ala Ile Ala Pro Asp Leu Lys Pro Val Arg Arg 
65                  70                  75                  80  


Phe Val Pro Asp Ser Trp Lys Asn Phe Phe Arg Gly Lys Lys Lys Asp 
                85                  90                  95      


Pro Glu Trp Asp Lys Pro Val Ser Asp Ile Arg Tyr Ile Ser Asp Gly 
            100                 105                 110         


Val Glu Cys Ser Pro Pro Ala Ser Pro Ala Arg Pro Asn His Arg Ser 
        115                 120                 125             


Pro Leu Asn Ser Cys Lys Asp Pro Tyr Gly Gly Ser Glu Gly Thr Phe 
    130                 135                 140                 


Ser Ser Arg Lys Glu Ala Asp Ala Val Phe Pro Arg Asp Pro Tyr Gly 
145                 150                 155                 160 


Ser Leu Asp Arg His Thr Gln Thr Val Arg Thr Tyr Ser Glu Lys Val 
                165                 170                 175     


Glu Glu Tyr Asn Leu Arg Tyr Ser Tyr Met Lys Ser Trp Ala Gly Leu 
            180                 185                 190         


Leu Arg Ile Leu Gly Val Val Glu Leu Leu Leu Gly Ala Gly Val Phe 
        195                 200                 205             


Ala Cys Val Thr Ala Tyr Ile His Lys Asp Ser Glu Trp Tyr Asn Leu 
    210                 215                 220                 


Phe Gly Tyr Ser Gln Pro Tyr Gly Met Gly Gly Val Gly Gly Leu Gly 
225                 230                 235                 240 


Ser Met Tyr Gly Gly Tyr Tyr Tyr Thr Gly Pro Lys Thr Pro Phe Val 
                245                 250                 255     


Leu Val Val Ala Gly Leu Ala Trp Ile Thr Thr Ile Ile Ile Leu Val 
            260                 265                 270         


Leu Gly Met Ser Met Tyr Tyr Arg Thr Ile Leu Leu Asp Ser Asn Trp 
        275                 280                 285             


Trp Pro Leu Thr Glu Phe Gly Ile Asn Val Ala Leu Phe Ile Leu Tyr 
    290                 295                 300                 


Met Ala Ala Ala Ile Val Tyr Val Asn Asp Thr Asn Arg Gly Gly Leu 
305                 310                 315                 320 


Cys Tyr Tyr Pro Leu Phe Asn Thr Pro Val Asn Ala Val Phe Cys Arg 
                325                 330                 335     


Val Glu Gly Gly Gln Ile Ala Ala Met Ile Phe Leu Phe Val Thr Met 
            340                 345                 350         


Ile Val Tyr Leu Ile Ser Ala Leu Val Cys Leu Lys Leu Trp Arg His 
        355                 360                 365             


Glu Ala Ala Arg Arg His Arg Glu Tyr Met Glu Gln Gln Glu Ile Asn 
    370                 375                 380                 


Glu Pro Ser Leu Ser Ser Lys Arg Lys Met Cys Glu Met Ala Thr Ser 
385                 390                 395                 400 


Gly Asp Arg Gln Arg Asp Ser Glu Val Asn Phe Lys Glu Leu Arg Thr 
                405                 410                 415     


Ala Lys Met Lys Pro Glu Leu Leu Ser Gly His Ile Pro Pro Gly His 
            420                 425                 430         


Ile Pro Lys Pro Ile Val Met Pro Asp Tyr Val Ala Lys Tyr Pro Val 
        435                 440                 445             


Ile Gln Thr Asp Asp Glu Arg Glu Arg Tyr Lys Ala Val Phe Gln Asp 
    450                 455                 460                 


Gln Phe Ser Glu Tyr Lys Glu Leu Ser Ala Glu Val Gln Ala Val Leu 
465                 470                 475                 480 


Arg Lys Phe Asp Glu Leu Asp Ala Val Met Ser Arg Leu Pro His His 
                485                 490                 495     


Ser Glu Ser Arg Gln Glu His Glu Arg Ile Ser Arg Ile His Glu Glu 
            500                 505                 510         


Phe Lys Lys Lys Lys Asn Asp Pro Thr Phe Leu Glu Lys Lys Glu Arg 
        515                 520                 525             


Cys Asp Tyr Leu Lys Asn Lys Leu Ser His Ile Lys Gln Arg Ile Gln 
    530                 535                 540                 


Glu Tyr Asp Lys Val Met Asn Trp Asp Val Gln Gly Tyr Ser 
545                 550                 555             


<210>  784
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  784

Met Ala Ser Ala Leu Trp Thr Val Leu Pro Ser Arg Met Ser Leu Arg 
1               5                   10                  15      


Ser Leu Lys Trp Ser Leu Leu Leu Leu Ser Leu Leu Ser Phe Phe Val 
            20                  25                  30          


Met Trp Tyr Leu Ser Leu Pro His Tyr Asn Val Ile Glu Arg Val Asn 
        35                  40                  45              


Trp Met Tyr Phe Tyr Glu Tyr Glu Pro Ile Tyr Arg Gln Asp Phe His 
    50                  55                  60                  


Phe Thr Leu Arg Glu His Ser Asn Cys Ser His Gln Asn Pro Phe Leu 
65                  70                  75                  80  


Val Ile Leu Val Thr Ser His Pro Ser Asp Val Lys Ala Arg Gln Ala 
                85                  90                  95      


Ile Arg Val Thr Trp Gly Glu Lys Lys Ser Trp Trp Gly Tyr Glu Val 
            100                 105                 110         


Leu Thr Phe Phe Leu Leu Gly Gln Glu Ala Glu Lys Glu Asp Lys Met 
        115                 120                 125             


Leu Ala Leu Ser Leu Glu Asp Glu His Leu Leu Tyr Gly Asp Ile Ile 
    130                 135                 140                 


Arg Gln Asp Phe Leu Asp Thr Tyr Asn Asn Leu Thr Leu Lys Thr Ile 
145                 150                 155                 160 


Met Ala Phe Arg Trp Val Thr Glu Phe Cys Pro Asn Ala Lys Tyr Val 
                165                 170                 175     


Met Lys Thr Asp Thr Asp Val Phe Ile Asn Thr Gly Asn Leu Val Lys 
            180                 185                 190         


Tyr Leu Leu Asn Leu Asn His Ser Glu Lys Phe Phe Thr Gly Tyr Pro 
        195                 200                 205             


Leu Ile Asp Asn Tyr Ser Tyr Arg Gly Phe Tyr Gln Lys Thr His Ile 
    210                 215                 220                 


Ser Tyr Gln Glu Tyr Pro Phe Lys Val Phe Pro Pro Tyr Cys Ser Gly 
225                 230                 235                 240 


Leu Gly Tyr Ile Met Ser Arg Asp Leu Val Pro Arg Ile Tyr Glu Met 
                245                 250                 255     


Met Gly His Val Lys Pro Ile Lys Phe Glu Asp Val Tyr Val Gly Ile 
            260                 265                 270         


Cys Leu Asn Leu Leu Lys Val Asn Ile His Ile Pro Glu Asp Thr Asn 
        275                 280                 285             


Leu Phe Phe Leu Tyr Arg Ile His Leu Asp Val Cys Gln Leu Arg Arg 
    290                 295                 300                 


Val Ile Ala Ala His Gly Phe Ser Ser Lys Glu Ile Ile Thr Phe Trp 
305                 310                 315                 320 


Gln Val Met Leu Arg Asn Thr Thr Cys His Tyr 
                325                 330     


<210>  785
<211>  617
<212>  PRT
<213>  Homo sapiens

<400>  785

Met Leu Leu Ala Arg Met Asn Pro Gln Val Gln Pro Glu Asn Asn Gly 
1               5                   10                  15      


Ala Asp Thr Gly Pro Glu Gln Pro Leu Arg Ala Arg Lys Thr Ala Glu 
            20                  25                  30          


Leu Leu Val Val Lys Glu Arg Asn Gly Val Gln Cys Leu Leu Ala Pro 
        35                  40                  45              


Arg Asp Gly Asp Ala Gln Pro Arg Glu Thr Trp Gly Lys Lys Ile Asp 
    50                  55                  60                  


Phe Leu Leu Ser Val Val Gly Phe Ala Val Asp Leu Ala Asn Val Trp 
65                  70                  75                  80  


Arg Phe Pro Tyr Leu Cys Tyr Lys Asn Gly Gly Gly Ala Phe Leu Ile 
                85                  90                  95      


Pro Tyr Thr Leu Phe Leu Ile Ile Ala Gly Met Pro Leu Phe Tyr Met 
            100                 105                 110         


Glu Leu Ala Leu Gly Gln Tyr Asn Arg Glu Gly Ala Ala Thr Val Trp 
        115                 120                 125             


Lys Ile Cys Pro Phe Phe Lys Gly Val Gly Tyr Ala Val Ile Leu Ile 
    130                 135                 140                 


Ala Leu Tyr Val Gly Phe Tyr Tyr Asn Val Ile Ile Ala Trp Ser Leu 
145                 150                 155                 160 


Tyr Tyr Leu Phe Ser Ser Phe Thr Leu Asn Leu Pro Trp Thr Asp Cys 
                165                 170                 175     


Gly His Thr Trp Asn Ser Pro Asn Cys Thr Asp Pro Lys Leu Leu Asn 
            180                 185                 190         


Gly Ser Val Leu Gly Asn His Thr Lys Tyr Ser Lys Tyr Lys Phe Thr 
        195                 200                 205             


Pro Ala Ala Glu Phe Tyr Glu Arg Gly Val Leu His Leu His Glu Ser 
    210                 215                 220                 


Ser Gly Ile His Asp Ile Gly Leu Pro Gln Trp Gln Leu Leu Leu Cys 
225                 230                 235                 240 


Leu Met Val Val Val Ile Val Leu Tyr Phe Ser Leu Trp Lys Gly Val 
                245                 250                 255     


Lys Thr Ser Gly Lys Val Val Trp Ile Thr Ala Thr Leu Pro Tyr Phe 
            260                 265                 270         


Val Leu Phe Val Leu Leu Val His Gly Val Thr Leu Pro Gly Ala Ser 
        275                 280                 285             


Asn Gly Ile Asn Ala Tyr Leu His Ile Asp Phe Tyr Arg Leu Lys Glu 
    290                 295                 300                 


Ala Thr Val Trp Ile Asp Ala Ala Thr Gln Ile Phe Phe Ser Leu Gly 
305                 310                 315                 320 


Ala Gly Phe Gly Val Leu Ile Ala Phe Ala Ser Tyr Asn Lys Phe Asp 
                325                 330                 335     


Asn Asn Cys Tyr Arg Asp Ala Leu Leu Thr Ser Ser Ile Asn Cys Ile 
            340                 345                 350         


Thr Ser Phe Val Ser Gly Phe Ala Ile Phe Ser Ile Leu Gly Tyr Met 
        355                 360                 365             


Ala His Glu His Lys Val Asn Ile Glu Asp Val Ala Thr Glu Gly Ala 
    370                 375                 380                 


Gly Leu Val Phe Ile Leu Tyr Pro Glu Ala Ile Ser Thr Leu Ser Gly 
385                 390                 395                 400 


Ser Thr Phe Trp Ala Val Val Phe Phe Val Met Leu Leu Ala Leu Gly 
                405                 410                 415     


Leu Asp Ser Ser Met Gly Gly Met Glu Ala Val Ile Thr Gly Leu Ala 
            420                 425                 430         


Asp Asp Phe Gln Val Leu Lys Arg His Arg Lys Leu Phe Thr Phe Gly 
        435                 440                 445             


Val Thr Phe Ser Thr Phe Leu Leu Ala Leu Phe Cys Ile Thr Lys Gly 
    450                 455                 460                 


Gly Ile Tyr Val Leu Thr Leu Leu Asp Thr Phe Ala Ala Gly Thr Ser 
465                 470                 475                 480 


Ile Leu Phe Ala Val Leu Met Glu Ala Ile Gly Val Ser Trp Phe Tyr 
                485                 490                 495     


Gly Val Asp Arg Phe Ser Asn Asp Ile Gln Gln Met Met Gly Phe Arg 
            500                 505                 510         


Pro Gly Leu Tyr Trp Arg Leu Cys Trp Lys Phe Val Ser Pro Ala Phe 
        515                 520                 525             


Leu Leu Phe Val Val Val Val Ser Ile Ile Asn Phe Lys Pro Leu Thr 
    530                 535                 540                 


Tyr Asp Asp Tyr Ile Phe Pro Pro Trp Ala Asn Trp Val Gly Trp Gly 
545                 550                 555                 560 


Ile Ala Leu Ser Ser Met Val Leu Val Pro Ile Tyr Val Ile Tyr Lys 
                565                 570                 575     


Phe Leu Ser Thr Gln Gly Ser Leu Trp Glu Arg Leu Ala Tyr Gly Ile 
            580                 585                 590         


Thr Pro Glu Asn Glu His His Leu Val Ala Gln Arg Asp Ile Arg Gln 
        595                 600                 605             


Phe Gln Leu Gln His Trp Leu Ala Ile 
    610                 615         


<210>  786
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  786

Met Leu Ala Pro Gly Ser Ser Pro Gly Gln Arg Gly Arg Leu Ala Leu 
1               5                   10                  15      


Gln Trp Arg Gln Val Ser Trp Ile Thr Cys Trp Ile Ala Leu Tyr Ala 
            20                  25                  30          


Val Glu Ala Leu Pro Thr Cys Pro Phe Ser Cys Lys Cys Asp Ser Arg 
        35                  40                  45              


Ser Leu Glu Val Asp Cys Ser Gly Leu Gly Leu Thr Thr Val Pro Pro 
    50                  55                  60                  


Asp Val Pro Ala Ala Thr Arg Thr Leu Leu Leu Leu Asn Asn Lys Leu 
65                  70                  75                  80  


Ser Ala Leu Pro Ser Trp Ala Phe Ala Asn Leu Ser Ser Leu Gln Arg 
                85                  90                  95      


Leu Asp Leu Ser Asn Asn Phe Leu Asp Arg Leu Pro Arg Ser Ile Phe 
            100                 105                 110         


Gly Asp Leu Thr Asn Leu Thr Glu Leu Gln Leu Arg Asn Asn Ser Ile 
        115                 120                 125             


Arg Thr Leu Asp Arg Asp Leu Leu Arg His Ser Pro Leu Leu Arg His 
    130                 135                 140                 


Leu Asp Leu Ser Ile Asn Gly Leu Ala Gln Leu Pro Pro Gly Leu Phe 
145                 150                 155                 160 


Asp Gly Leu Leu Ala Leu Arg Ser Leu Ser Leu Arg Ser Asn Arg Leu 
                165                 170                 175     


Gln Asn Leu Asp Arg Leu Thr Phe Glu Pro Leu Ala Asn Leu Gln Leu 
            180                 185                 190         


Leu Gln Val Gly Asp Asn Pro Trp Glu Cys Asp Cys Asn Leu Arg Glu 
        195                 200                 205             


Phe Lys His Trp Met Glu Trp Phe Ser Tyr Arg Gly Gly Arg Leu Asp 
    210                 215                 220                 


Gln Leu Ala Cys Thr Leu Pro Lys Glu Leu Arg Gly Lys Asp Met Arg 
225                 230                 235                 240 


Met Val Pro Met Glu Met Phe Asn Tyr Cys Ser Gln Leu Glu Asp Glu 
                245                 250                 255     


Asn Ser Ser Ala Gly Leu Asp Ile Pro Gly Pro Pro Cys Thr Lys Ala 
            260                 265                 270         


Ser Pro Glu Pro Ala Lys Pro Lys Pro Gly Ala Glu Pro Glu Pro Glu 
        275                 280                 285             


Pro Ser Thr Ala Cys Pro Gln Lys Gln Arg His Arg Pro Ala Ser Val 
    290                 295                 300                 


Arg Arg Ala Met Gly Thr Val Ile Ile Ala Gly Val Val Cys Gly Val 
305                 310                 315                 320 


Val Cys Ile Met Met Val Val Ala Ala Ala Tyr Gly Cys Ile Tyr Ala 
                325                 330                 335     


Ser Leu Met Ala Lys Tyr His Arg Glu Leu Lys Lys Arg Gln Pro Leu 
            340                 345                 350         


Met Gly Asp Pro Glu Gly Glu His Glu Asp Gln Lys Gln Ile Ser Ser 
        355                 360                 365             


Val Ala 
    370 


<210>  787
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  787

Met Gly Ser Leu Phe Pro Leu Ser Leu Leu Phe Phe Leu Ala Ala Ala 
1               5                   10                  15      


Tyr Pro Gly Val Gly Ser Ala Leu Gly Arg Arg Thr Lys Arg Ala Gln 
            20                  25                  30          


Ser Pro Lys Gly Ser Pro Leu Ala Pro Ser Gly Thr Ser Val Pro Phe 
        35                  40                  45              


Trp Val Arg Met Ser Pro Glu Phe Val Ala Val Gln Pro Gly Lys Ser 
    50                  55                  60                  


Val Gln Leu Asn Cys Ser Asn Ser Cys Pro Gln Pro Gln Asn Ser Ser 
65                  70                  75                  80  


Leu Arg Thr Pro Leu Arg Gln Gly Lys Thr Leu Arg Gly Pro Gly Trp 
                85                  90                  95      


Val Ser Tyr Gln Leu Leu Asp Val Arg Ala Trp Ser Ser Leu Ala His 
            100                 105                 110         


Cys Leu Val Thr Cys Ala Gly Lys Thr Arg Trp Ala Thr Ser Arg Ile 
        115                 120                 125             


Thr Ala Tyr Ser Val Pro Gly Gly Leu Leu Gly Gly Asp Pro Glu Ala 
    130                 135                 140                 


Trp Lys Pro Gly His Leu Phe Arg Lys Pro Gly Ala Leu His Arg Pro 
145                 150                 155                 160 


Gly Ser Gly Gln Arg Asp Leu Asp Leu Arg Val Cys Cys Trp Thr Pro 
                165                 170                 175     


Arg Leu Leu Ala Ala Arg Asp Leu Pro Arg Ala Pro Gln Ser Arg Arg 
            180                 185                 190         


Pro Gly Gly Pro Gln Gln Leu Gly Thr His Tyr Thr Asp Ala Arg Leu 
        195                 200                 205             


Glu Pro Arg Ala His Ser Phe Gly Leu Arg Phe His Arg Cys Pro Cys 
    210                 215                 220                 


Arg Asp Pro Pro His Cys Gly Arg Cys Val Pro Met Gln Val Pro Ser 
225                 230                 235                 240 


Tyr Glu Val Pro Gly Val Lys Gly Asp Val Leu Cys Arg Leu Ser Glu 
                245                 250                 255     


Lys Lys Arg Asn Met Lys Gln Ser Gly Glu Met Ala Ile His Gly Gly 
            260                 265                 270         


<210>  788
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  788

Met Ala Ser Val Val Pro Val Lys Asp Lys Lys Leu Leu Glu Val Lys 
1               5                   10                  15      


Leu Gly Glu Leu Pro Ser Trp Ile Leu Met Arg Asp Phe Ser Pro Ser 
            20                  25                  30          


Gly Ile Phe Gly Ala Phe Gln Arg Glu His Glu Arg Leu Arg Lys Tyr 
        35                  40                  45              


His 
    


<210>  789
<211>  801
<212>  PRT
<213>  Homo sapiens

<400>  789

Met Lys Glu Lys Ala Met Ile Lys Thr Ala Lys Met Gln Gly Asn Val 
1               5                   10                  15      


Met Glu Leu Val Gly Ser Asn Pro Pro Gln Arg Asn Trp Lys Gly Ile 
            20                  25                  30          


Ala Ile Ala Leu Leu Val Ile Leu Val Ile Cys Ser Leu Ile Val Thr 
        35                  40                  45              


Ser Val Ile Leu Leu Thr Pro Ala Glu Asp Asn Ser Leu Ser Gln Lys 
    50                  55                  60                  


Lys Lys Val Thr Val Glu Asp Leu Phe Ser Glu Asp Phe Lys Ile His 
65                  70                  75                  80  


Asp Pro Glu Ala Lys Trp Ile Ser Asp Thr Glu Phe Ile Tyr Arg Glu 
                85                  90                  95      


Gln Lys Gly Thr Val Arg Leu Trp Asn Val Glu Thr Asn Thr Ser Thr 
            100                 105                 110         


Val Leu Ile Glu Gly Lys Lys Ile Glu Ser Leu Arg Ala Ile Arg Tyr 
        115                 120                 125             


Glu Ile Ser Pro Asp Arg Glu Tyr Ala Leu Phe Ser Tyr Asn Val Glu 
    130                 135                 140                 


Pro Ile Tyr Gln His Ser Tyr Thr Gly Tyr Tyr Val Leu Ser Lys Ile 
145                 150                 155                 160 


Pro His Gly Asp Pro Gln Ser Leu Asp Pro Pro Glu Val Ser Asn Ala 
                165                 170                 175     


Lys Leu Gln Tyr Ala Gly Trp Gly Pro Lys Gly Gln Gln Leu Ile Phe 
            180                 185                 190         


Ile Phe Glu Asn Asn Ile Tyr Tyr Cys Ala His Val Gly Lys Gln Ala 
        195                 200                 205             


Ile Arg Val Val Ser Thr Gly Lys Glu Gly Val Ile Tyr Asn Gly Leu 
    210                 215                 220                 


Ser Asp Trp Leu Tyr Glu Glu Glu Ile Leu Lys Thr His Ile Ala His 
225                 230                 235                 240 


Trp Trp Ser Pro Asp Gly Thr Arg Leu Ala Tyr Ala Ala Ile Asn Asp 
                245                 250                 255     


Ser Arg Val Pro Ile Met Glu Leu Pro Thr Tyr Thr Gly Ser Ile Tyr 
            260                 265                 270         


Pro Thr Val Lys Pro Tyr His Tyr Pro Lys Ala Gly Ser Glu Asn Pro 
        275                 280                 285             


Ser Ile Ser Leu His Val Ile Gly Leu Asn Gly Pro Thr His Asp Leu 
    290                 295                 300                 


Glu Met Met Pro Pro Asp Asp Pro Arg Met Arg Glu Tyr Tyr Ile Thr 
305                 310                 315                 320 


Met Val Lys Trp Ala Thr Ser Thr Lys Val Ala Val Thr Trp Leu Asn 
                325                 330                 335     


Arg Ala Gln Asn Val Ser Ile Leu Thr Leu Cys Asp Ala Thr Thr Gly 
            340                 345                 350         


Val Cys Thr Lys Lys His Glu Asp Glu Ser Glu Ala Trp Leu His Arg 
        355                 360                 365             


Gln Asn Glu Glu Pro Val Phe Ser Lys Asp Gly Arg Lys Phe Phe Phe 
    370                 375                 380                 


Ile Arg Ala Ile Pro Gln Gly Gly Arg Gly Lys Phe Tyr His Ile Thr 
385                 390                 395                 400 


Val Ser Ser Ser Gln Pro Asn Ser Ser Asn Asp Asn Ile Gln Ser Ile 
                405                 410                 415     


Thr Ser Gly Asp Trp Asp Val Thr Lys Ile Leu Ala Tyr Asp Glu Lys 
            420                 425                 430         


Gly Asn Lys Ile Tyr Phe Leu Ser Thr Glu Asp Leu Pro Arg Arg Arg 
        435                 440                 445             


Gln Leu Tyr Ser Ala Asn Thr Val Gly Asn Phe Asn Arg Gln Cys Leu 
    450                 455                 460                 


Ser Cys Asp Leu Val Glu Asn Cys Thr Tyr Phe Ser Ala Ser Phe Ser 
465                 470                 475                 480 


His Ser Met Asp Phe Phe Leu Leu Lys Cys Glu Gly Pro Gly Val Pro 
                485                 490                 495     


Met Val Thr Val His Asn Thr Thr Asp Lys Lys Lys Met Phe Asp Leu 
            500                 505                 510         


Glu Thr Asn Glu His Val Lys Lys Ala Ile Asn Asp Arg Gln Met Pro 
        515                 520                 525             


Lys Val Glu Tyr Arg Asp Ile Glu Ile Asp Asp Tyr Asn Leu Pro Met 
    530                 535                 540                 


Gln Ile Leu Lys Pro Ala Thr Phe Thr Asp Thr Thr His Tyr Pro Leu 
545                 550                 555                 560 


Leu Leu Val Val Asp Gly Thr Pro Gly Ser Gln Ser Val Ala Glu Lys 
                565                 570                 575     


Phe Glu Val Ser Trp Glu Thr Val Met Val Ser Ser His Gly Ala Val 
            580                 585                 590         


Val Val Lys Cys Asp Gly Arg Gly Ser Gly Phe Gln Gly Thr Lys Leu 
        595                 600                 605             


Leu His Glu Val Arg Arg Arg Leu Gly Leu Leu Glu Glu Lys Asp Gln 
    610                 615                 620                 


Met Glu Ala Val Arg Thr Met Leu Lys Glu Gln Tyr Ile Asp Arg Thr 
625                 630                 635                 640 


Arg Val Ala Val Phe Gly Lys Asp Tyr Gly Gly Tyr Leu Ser Thr Tyr 
                645                 650                 655     


Ile Leu Pro Ala Lys Gly Glu Asn Gln Gly Gln Thr Phe Thr Cys Gly 
            660                 665                 670         


Ser Ala Leu Ser Pro Ile Thr Asp Phe Lys Leu Tyr Ala Ser Ala Phe 
        675                 680                 685             


Ser Glu Arg Tyr Leu Gly Leu His Gly Leu Asp Asn Arg Ala Tyr Glu 
    690                 695                 700                 


Met Thr Lys Val Ala His Arg Val Ser Ala Leu Glu Glu Gln Gln Phe 
705                 710                 715                 720 


Leu Ile Ile His Pro Thr Ala Asp Glu Lys Ile His Phe Gln His Thr 
                725                 730                 735     


Ala Glu Leu Ile Thr Gln Leu Ile Arg Gly Lys Ala Asn Tyr Ser Leu 
            740                 745                 750         


Gln Ile Tyr Pro Asp Glu Ser His Tyr Phe Thr Ser Ser Ser Leu Lys 
        755                 760                 765             


Gln His Leu Tyr Arg Ser Ile Ile Asn Phe Phe Val Glu Cys Phe Arg 
    770                 775                 780                 


Ile Gln Asp Lys Leu Leu Thr Val Thr Ala Lys Glu Asp Glu Glu Glu 
785                 790                 795                 800 


Asp 
    


<210>  790
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  790

Met Gly Gln Asp Ala Phe Met Glu Pro Phe Gly Asp Thr Leu Gly Val 
1               5                   10                  15      


Phe Gln Cys Lys Ile Tyr Leu Leu Leu Phe Gly Ala Cys Ser Gly Leu 
            20                  25                  30          


Lys Val Thr Val Pro Ser His Thr Val His Gly Val Arg Gly Gln Ala 
        35                  40                  45              


Leu Tyr Leu Pro Val His Tyr Gly Phe His Thr Pro Ala Ser Asp Ile 
    50                  55                  60                  


Gln Ile Ile Trp Leu Phe Glu Arg Pro His Thr Met Pro Lys Tyr Leu 
65                  70                  75                  80  


Leu Gly Ser Val Asn Lys Ser Val Val Pro Asp Leu Glu Tyr Gln His 
                85                  90                  95      


Lys Phe Thr Met Met Pro Pro Asn Ala Ser Leu Leu Ile Asn Pro Leu 
            100                 105                 110         


Gln Phe Pro Asp Glu Gly Asn Tyr Ile Val Lys Val Asn Ile Gln Gly 
        115                 120                 125             


Asn Gly Thr Leu Ser Ala Ser Gln Lys Ile Gln Val Thr Val Asp Asp 
    130                 135                 140                 


Pro Val Thr Lys Pro Val Val Gln Ile His Pro Pro Ser Gly Ala Val 
145                 150                 155                 160 


Glu Tyr Val Gly Asn Met Thr Leu Thr Cys His Val Glu Gly Gly Thr 
                165                 170                 175     


Arg Leu Ala Tyr Gln Trp Leu Lys Asn Gly Arg Pro Val His Thr Ser 
            180                 185                 190         


Ser Thr Tyr Ser Phe Ser Pro Gln Asn Asn Thr Leu His Ile Ala Pro 
        195                 200                 205             


Val Thr Lys Glu Asp Ile Gly Asn Tyr Ser Cys Leu Val Arg Asn Pro 
    210                 215                 220                 


Val Ser Glu Met Glu Ser Asp Ile Ile Met Pro Ile Ile Tyr Tyr Gly 
225                 230                 235                 240 


Pro Tyr Gly Leu Gln Val Asn Ser Asp Lys Gly Leu Lys Val Gly Glu 
                245                 250                 255     


Val Phe Thr Val Asp Leu Gly Glu Ala Ile Leu Phe Asp Cys Ser Ala 
            260                 265                 270         


Asp Ser His Pro Pro Asn Thr Tyr Ser Trp Ile Arg Arg Thr Asp Asn 
        275                 280                 285             


Thr Thr Tyr Ile Ile Lys His Gly Pro Arg Leu Glu Val Ala Ser Glu 
    290                 295                 300                 


Lys Val Ala Gln Lys Thr Met Asp Tyr Val Cys Cys Ala Tyr Asn Asn 
305                 310                 315                 320 


Ile Thr Gly Arg Gln Asp Glu Thr His Phe Thr Val Ile Ile Thr Ser 
                325                 330                 335     


Val Gly Leu Glu Lys Leu Ala Gln Lys Gly Lys Ser Leu Ser Pro Leu 
            340                 345                 350         


Ala Ser Ile Thr Gly Ile Ser Leu Phe Leu Ile Ile Ser Met Cys Leu 
        355                 360                 365             


Leu Phe Leu Trp Lys Lys Tyr Gln Pro Tyr Lys Val Ile Lys Gln Lys 
    370                 375                 380                 


Leu Glu Gly Arg Pro Glu Thr Glu Tyr Arg Lys Ala Gln Thr Phe Ser 
385                 390                 395                 400 


Gly His Glu Asp Ala Leu Asp Asp Phe Gly Ile Tyr Glu Phe Val Ala 
                405                 410                 415     


Phe Pro Asp Val Ser Gly Val Ser Arg Ile Pro Ser Arg Ser Val Pro 
            420                 425                 430         


Ala Ser Asp Cys Val Ser Gly Gln Asp Leu His Ser Thr Val Tyr Glu 
        435                 440                 445             


Val Ile Gln His Ile Pro Ala Gln Gln Gln Asp His Pro Glu 
    450                 455                 460         


<210>  791
<211>  534
<212>  PRT
<213>  Homo sapiens

<400>  791

Met Arg Arg His Ser Glu Thr Asp Val Glu Glu Gln Thr Gln Glu Leu 
1               5                   10                  15      


Lys Thr Ile Thr Gln Leu Gln Glu Gln Cys Arg Ala Leu Gln Ile Gln 
            20                  25                  30          


Gly Val Lys Glu Asn Met Asp Gln Asn Lys Ala Thr Leu Ala Leu Leu 
        35                  40                  45              


Arg Ser Asn Ile Arg Arg Gly Ala Gln Asp Trp Ala Leu Ala Lys Lys 
    50                  55                  60                  


Tyr Asp Gln Trp Thr Ile Ser Lys Ala Cys Gly Lys Asn Leu Pro Leu 
65                  70                  75                  80  


Arg Leu Ala His Cys Arg Ser Thr Met Glu Val Val Arg Glu Lys Leu 
                85                  90                  95      


Arg Lys Tyr Val Phe Asp Arg Val Asn Met His Asn Leu Leu Ile His 
            100                 105                 110         


Leu Val Arg Arg Arg Gly Gln Lys Leu Glu Ser Met Gln Leu Glu Leu 
        115                 120                 125             


Asp Ser Leu Arg Ser Gln Pro Asp Ala Ser Lys Glu Glu Leu Arg Leu 
    130                 135                 140                 


Leu Gln Ile Ile Arg Gln Leu Glu Asn Asn Ile Glu Lys Thr Met Ile 
145                 150                 155                 160 


Lys Ile Ile Thr Ser Gln Asn Ile His Leu Leu Tyr Leu Asp Leu Leu 
                165                 170                 175     


Asp Tyr Leu Lys Thr Val Leu Ala Gly Tyr Pro Ile Glu Leu Asp Lys 
            180                 185                 190         


Leu Gln Asn Leu Val Val Asn Tyr Cys Ser Glu Leu Ser Asp Met Lys 
        195                 200                 205             


Ile Met Ser Gln Asp Ala Met Met Ile Thr Asp Glu Val Lys Arg Asn 
    210                 215                 220                 


Met Arg Gln Arg Glu Ala Ser Phe Ile Glu Glu Arg Arg Ala Arg Glu 
225                 230                 235                 240 


Asn Arg Leu Asn Gln Gln Lys Lys Leu Ile Asp Lys Ile His Thr Lys 
                245                 250                 255     


Glu Thr Ser Glu Lys Tyr Arg Arg Gly Gln Met Asp Leu Asp Phe Pro 
            260                 265                 270         


Ser Asn Leu Met Ser Thr Glu Thr Leu Lys Leu Arg Arg Lys Glu Thr 
        275                 280                 285             


Ser Thr Ala Glu Met Glu Tyr Gln Ser Gly Val Thr Ala Val Val Glu 
    290                 295                 300                 


Lys Val Lys Ser Ala Val Arg Cys Ser His Val Trp Asp Ile Thr Ser 
305                 310                 315                 320 


Arg Phe Leu Ala Gln Arg Asn Thr Glu Glu Asn Leu Glu Leu Gln Met 
                325                 330                 335     


Glu Asp Cys Glu Glu Trp Arg Val Gln Leu Lys Ala Leu Val Lys Gln 
            340                 345                 350         


Leu Glu Leu Glu Glu Ala Val Leu Lys Phe Arg Gln Lys Pro Ser Ser 
        355                 360                 365             


Ile Ser Phe Lys Ser Val Glu Lys Lys Met Thr Asp Met Leu Lys Glu 
    370                 375                 380                 


Glu Glu Glu Arg Leu Gln Leu Ala His Ser Asn Met Thr Lys Gly Gln 
385                 390                 395                 400 


Glu Leu Leu Leu Thr Ile Gln Met Gly Ile Asp Asn Leu Tyr Val Arg 
                405                 410                 415     


Leu Met Gly Ile Asn Leu Pro Ala Thr Gln Arg Glu Val Val Leu Ser 
            420                 425                 430         


Asn Thr Leu Asp Leu Asn Ser Lys Leu Ala Tyr Cys Glu Gly Lys Leu 
        435                 440                 445             


Thr Tyr Leu Ala Asp Arg Val Gln Met Val Ser Arg Thr Glu Glu Gly 
    450                 455                 460                 


Asp Thr Lys Val Arg Asp Thr Leu Glu Ser Ser Thr Leu Met Glu Lys 
465                 470                 475                 480 


Tyr Asn Thr Arg Ile Ser Phe Glu Asn Arg Glu Glu Asp Met Ile Asp 
                485                 490                 495     


Thr Phe Gln Phe Pro Asp Met Asp His Ser Tyr Val Pro Ser Arg Ala 
            500                 505                 510         


Glu Ile Lys Arg Gln Ala Gln Arg Leu Ile Glu Gly Lys Leu Lys Ala 
        515                 520                 525             


Ala Lys Lys Lys Lys Lys 
    530                 


<210>  792
<211>  716
<212>  PRT
<213>  Homo sapiens

<400>  792

Met Asn Asn Phe Arg Ala Thr Ile Leu Phe Trp Ala Ala Ala Ala Trp 
1               5                   10                  15      


Ala Lys Ser Gly Lys Pro Ser Gly Glu Met Asp Glu Val Gly Val Gln 
            20                  25                  30          


Lys Cys Lys Asn Ala Leu Lys Leu Pro Val Leu Glu Val Leu Pro Gly 
        35                  40                  45              


Gly Gly Trp Asp Asn Leu Arg Asn Val Asp Met Gly Arg Val Met Glu 
    50                  55                  60                  


Leu Thr Tyr Ser Asn Cys Arg Thr Thr Glu Asp Gly Gln Tyr Ile Ile 
65                  70                  75                  80  


Pro Asp Glu Ile Phe Thr Ile Pro Gln Lys Gln Ser Asn Leu Glu Met 
                85                  90                  95      


Asn Ser Glu Ile Leu Glu Ser Trp Ala Asn Tyr Gln Ser Ser Thr Ser 
            100                 105                 110         


Tyr Ser Ile Asn Thr Glu Leu Ser Leu Phe Ser Lys Val Asn Gly Lys 
        115                 120                 125             


Phe Ser Thr Glu Phe Gln Arg Met Lys Thr Leu Gln Val Lys Asp Gln 
    130                 135                 140                 


Ala Ile Thr Thr Arg Val Gln Val Arg Asn Leu Val Tyr Thr Val Lys 
145                 150                 155                 160 


Ile Asn Pro Thr Leu Glu Leu Ser Ser Gly Phe Arg Lys Glu Leu Leu 
                165                 170                 175     


Asp Ile Ser Asp Arg Leu Glu Asn Asn Gln Thr Arg Met Ala Thr Tyr 
            180                 185                 190         


Leu Ala Glu Leu Leu Val Leu Asn Tyr Gly Thr His Val Thr Thr Ser 
        195                 200                 205             


Val Asp Ala Gly Ala Ala Leu Ile Gln Glu Asp His Leu Arg Ala Ser 
    210                 215                 220                 


Phe Leu Gln Asp Ser Gln Ser Ser Arg Ser Ala Val Thr Ala Ser Ala 
225                 230                 235                 240 


Gly Leu Ala Phe Gln Asn Thr Val Asn Phe Lys Phe Glu Glu Asn Tyr 
                245                 250                 255     


Thr Ser Gln Asn Val Leu Thr Lys Ser Tyr Leu Ser Asn Arg Thr Asn 
            260                 265                 270         


Ser Arg Val Gln Ser Ile Gly Gly Val Pro Phe Tyr Pro Gly Ile Thr 
        275                 280                 285             


Leu Gln Ala Trp Gln Gln Gly Ile Thr Asn His Leu Val Ala Ile Asp 
    290                 295                 300                 


Arg Ser Gly Leu Pro Leu His Phe Phe Ile Asn Pro Asn Met Leu Pro 
305                 310                 315                 320 


Asp Leu Pro Gly Pro Leu Val Lys Lys Val Ser Lys Thr Val Glu Thr 
                325                 330                 335     


Ala Val Lys Arg Tyr Tyr Thr Phe Asn Thr Tyr Pro Gly Cys Thr Asp 
            340                 345                 350         


Leu Asn Ser Pro Asn Phe Asn Phe Gln Ala Asn Thr Asp Asp Gly Ser 
        355                 360                 365             


Cys Glu Gly Lys Met Thr Asn Phe Ser Phe Gly Gly Val Tyr Gln Glu 
    370                 375                 380                 


Cys Thr Gln Leu Ser Gly Asn Arg Asp Val Leu Leu Cys Gln Lys Leu 
385                 390                 395                 400 


Glu Gln Lys Asn Pro Leu Thr Gly Asp Phe Ser Cys Pro Ser Gly Tyr 
                405                 410                 415     


Ser Pro Val His Leu Leu Ser Gln Ile His Glu Glu Gly Tyr Asn His 
            420                 425                 430         


Leu Glu Cys His Arg Lys Cys Thr Leu Leu Val Phe Cys Lys Thr Val 
        435                 440                 445             


Cys Glu Asp Val Phe Gln Val Ala Lys Ala Glu Phe Arg Ala Phe Trp 
    450                 455                 460                 


Cys Val Ala Ser Ser Gln Val Pro Glu Asn Ser Gly Leu Leu Phe Gly 
465                 470                 475                 480 


Gly Leu Phe Ser Ser Lys Ser Ile Asn Pro Met Thr Asn Ala Gln Ser 
                485                 490                 495     


Cys Pro Ala Gly Tyr Phe Pro Leu Arg Leu Phe Glu Asn Leu Lys Val 
            500                 505                 510         


Cys Val Ser Gln Asp Tyr Glu Leu Gly Ser Arg Phe Ala Val Pro Phe 
        515                 520                 525             


Gly Gly Phe Phe Ser Cys Thr Val Gly Asn Pro Leu Val Asp Pro Ala 
    530                 535                 540                 


Ile Ser Arg Asp Leu Gly Ala Pro Ser Leu Lys Lys Cys Pro Gly Gly 
545                 550                 555                 560 


Phe Ser Gln His Pro Ala Leu Ile Ser Asp Gly Cys Gln Val Ser Tyr 
                565                 570                 575     


Cys Val Lys Ser Gly Leu Phe Thr Gly Gly Ser Leu Pro Pro Ala Arg 
            580                 585                 590         


Leu Pro Pro Phe Thr Arg Pro Pro Leu Met Ser Gln Ala Ala Thr Asn 
        595                 600                 605             


Thr Val Ile Val Thr Asn Ser Glu Asn Ala Arg Ser Trp Ile Lys Asp 
    610                 615                 620                 


Ser Gln Thr His Gln Trp Arg Leu Gly Glu Pro Ile Glu Leu Arg Arg 
625                 630                 635                 640 


Ala Met Asn Val Ile His Gly Asp Gly Gly Gly Leu Ser Gly Gly Ala 
                645                 650                 655     


Ala Ala Gly Val Thr Val Gly Val Thr Thr Ile Leu Ala Val Val Ile 
            660                 665                 670         


Thr Leu Ala Ile Tyr Gly Thr Arg Lys Phe Lys Lys Lys Ala Tyr Gln 
        675                 680                 685             


Ala Ile Glu Glu Arg Gln Ser Leu Val Pro Gly Thr Ala Ala Thr Gly 
    690                 695                 700                 


Asp Thr Thr Tyr Gln Glu Gln Gly Gln Ser Pro Ala 
705                 710                 715     


<210>  793
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  793

Met Trp Ser Asn Leu Gly Ile Gly Leu Ala Ile Ser Leu Ser Val Val 
1               5                   10                  15      


Gly Ala Ala Trp Gly Ile Tyr Ile Thr Gly Ser Ser Ile Ile Gly Gly 
            20                  25                  30          


Gly Val Lys Ala Pro Arg Ile Lys Thr Lys Asn Leu Val Ser Ile Ile 
        35                  40                  45              


Phe Cys Glu Ala Val Ala Ile Tyr Gly Ile Ile Met Ala Ile Val Ile 
    50                  55                  60                  


Ser Asn Met Ala Glu Pro Phe Ser Ala Thr Asp Pro Lys Ala Ile Gly 
65                  70                  75                  80  


His Arg Asn Tyr His Ala Gly Tyr Ser Met Phe Gly Ala Gly Leu Thr 
                85                  90                  95      


Val Gly Leu Ser Asn Leu Phe Cys Gly Val Cys Val Gly Ile Val Gly 
            100                 105                 110         


Ser Gly Ala Ala Leu Ala Asp Ala Gln Asn Pro Ser Leu Phe Val Lys 
        115                 120                 125             


Ile Leu Ile Val Glu Ile Phe Gly Ser Ala Ile Gly Leu Phe Gly Val 
    130                 135                 140                 


Ile Val Ala Ile Leu Gln Thr Ser Arg Val Lys Met Gly Asp 
145                 150                 155             


<210>  794
<211>  823
<212>  PRT
<213>  Homo sapiens

<400>  794

Met Phe Tyr Val Ile Gly Gly Ile Thr Val Ser Val Val Ala Phe Phe 
1               5                   10                  15      


Phe Thr Ile Lys Phe Leu Phe Glu Leu Ala Ala Arg Val Val Ser Phe 
            20                  25                  30          


Leu Gln Asn Glu Asp Arg Glu Arg Arg Gly Asp Arg Thr Ile Tyr Asp 
        35                  40                  45              


Tyr Val Arg Gly Asn Tyr Leu Asp Pro Arg Ser Cys Lys Val Ser Trp 
    50                  55                  60                  


Asp Trp Lys Asp Pro Tyr Glu Val Gly His Ser Met Ala Phe Arg Val 
65                  70                  75                  80  


His Leu Phe Tyr Lys Asn Gly Gln Pro Phe Pro Ala His Arg Pro Val 
                85                  90                  95      


Gly Leu Arg Val His Ile Ser His Val Glu Leu Ala Val Glu Ile Pro 
            100                 105                 110         


Val Thr Gln Glu Val Leu Gln Glu Pro Asn Ser Asn Val Val Lys Val 
        115                 120                 125             


Ala Phe Thr Val Arg Lys Ala Gly Arg Tyr Glu Ile Thr Val Lys Leu 
    130                 135                 140                 


Gly Gly Leu Asn Val Ala Tyr Ser Pro Tyr Tyr Lys Ile Phe Gln Pro 
145                 150                 155                 160 


Gly Met Val Val Pro Ser Lys Thr Lys Ile Val Cys His Phe Ser Thr 
                165                 170                 175     


Leu Val Leu Thr Cys Gly Gln Pro His Thr Leu Gln Ile Val Pro Arg 
            180                 185                 190         


Asp Glu Tyr Asp Asn Pro Thr Asn Asn Ser Met Ser Leu Arg Asp Glu 
        195                 200                 205             


His Asn Tyr Thr Leu Ser Ile His Glu Leu Gly Pro Gln Glu Glu Glu 
    210                 215                 220                 


Ser Thr Gly Val Ser Phe Glu Lys Ser Val Thr Ser Asn Arg Gln Thr 
225                 230                 235                 240 


Phe Gln Val Phe Leu Arg Leu Thr Leu His Ser Arg Gly Cys Phe His 
                245                 250                 255     


Ala Cys Ile Ser Tyr Gln Asn Gln Pro Ile Asn Asn Gly Glu Phe Asp 
            260                 265                 270         


Ile Ile Val Leu Ser Glu Asp Glu Lys Asn Ile Val Glu Arg Asn Val 
        275                 280                 285             


Ser Thr Ser Gly Val Ser Ile Tyr Phe Glu Ala Tyr Leu Tyr Asn Ala 
    290                 295                 300                 


Thr Asn Cys Ser Ser Thr Pro Trp His Leu Pro Pro Met His Met Thr 
305                 310                 315                 320 


Ser Ser Gln Arg Arg Pro Ser Thr Ala Val Asp Glu Glu Asp Glu Asp 
                325                 330                 335     


Ser Pro Ser Glu Cys His Thr Pro Glu Lys Val Lys Lys Pro Lys Lys 
            340                 345                 350         


Val Tyr Cys Tyr Val Ser Pro Lys Gln Phe Ser Val Lys Glu Phe Tyr 
        355                 360                 365             


Leu Lys Ile Ile Pro Trp Arg Leu Tyr Thr Phe Arg Val Cys Pro Gly 
    370                 375                 380                 


Thr Lys Phe Ser Tyr Leu Gly Pro Asp Pro Val His Lys Leu Leu Thr 
385                 390                 395                 400 


Leu Val Val Asp Asp Gly Ile Gln Pro Pro Val Glu Leu Ser Cys Lys 
                405                 410                 415     


Glu Arg Asn Ile Leu Ala Ala Thr Phe Ile Arg Ser Leu His Lys Asn 
            420                 425                 430         


Ile Gly Gly Ser Glu Thr Phe Gln Asp Lys Val Asn Phe Phe Gln Arg 
        435                 440                 445             


Glu Leu Arg Gln Val His Met Lys Arg Pro His Ser Lys Val Thr Leu 
    450                 455                 460                 


Lys Val Ser Arg His Ala Leu Leu Glu Ser Ser Leu Lys Ala Thr Arg 
465                 470                 475                 480 


Asn Phe Ser Ile Ser Asp Trp Ser Lys Asn Phe Glu Val Val Phe Gln 
                485                 490                 495     


Asp Glu Glu Ala Leu Asp Trp Gly Gly Pro Arg Arg Glu Trp Phe Glu 
            500                 505                 510         


Leu Ile Cys Lys Ala Leu Phe Asp Thr Thr Asn Gln Leu Phe Thr Arg 
        515                 520                 525             


Phe Ser Asp Asn Asn Gln Ala Leu Val His Pro Asn Pro Asn Arg Pro 
    530                 535                 540                 


Ala His Leu Arg Leu Lys Met Tyr Glu Phe Ala Gly Arg Leu Val Gly 
545                 550                 555                 560 


Lys Cys Leu Tyr Glu Ser Ser Leu Gly Gly Ala Tyr Lys Gln Leu Val 
                565                 570                 575     


Arg Ala Arg Phe Thr Arg Ser Phe Leu Ala Gln Ile Ile Gly Leu Arg 
            580                 585                 590         


Met His Tyr Lys Tyr Phe Glu Thr Asp Asp Pro Glu Phe Tyr Lys Ser 
        595                 600                 605             


Lys Val Cys Phe Ile Leu Asn Asn Asp Met Ser Glu Met Glu Leu Val 
    610                 615                 620                 


Phe Ala Glu Glu Lys Tyr Asn Lys Ser Gly Gln Leu Asp Lys Val Val 
625                 630                 635                 640 


Glu Leu Met Thr Gly Gly Ala Gln Thr Pro Val Thr Asn Ala Asn Lys 
                645                 650                 655     


Ile Phe Tyr Leu Asn Leu Leu Ala Gln Tyr Arg Leu Ala Ser Gln Val 
            660                 665                 670         


Lys Glu Glu Val Glu His Phe Leu Lys Gly Leu Asn Glu Leu Val Pro 
        675                 680                 685             


Glu Asn Leu Leu Ala Ile Phe Asp Glu Asn Glu Leu Glu Leu Leu Met 
    690                 695                 700                 


Cys Gly Thr Gly Asp Ile Ser Val Ser Asp Phe Lys Ala His Ala Val 
705                 710                 715                 720 


Val Val Gly Gly Ser Trp His Phe Arg Glu Lys Val Met Arg Trp Phe 
                725                 730                 735     


Trp Thr Val Val Ser Ser Leu Thr Gln Glu Glu Leu Ala Arg Leu Leu 
            740                 745                 750         


Gln Phe Thr Thr Gly Ser Ser Gln Leu Pro Pro Gly Gly Phe Ala Ala 
        755                 760                 765             


Leu Cys Pro Ser Phe Gln Ile Ile Ala Ala Pro Thr His Ser Thr Leu 
    770                 775                 780                 


Pro Thr Ala His Thr Cys Phe Asn Gln Leu Cys Leu Pro Thr Tyr Asp 
785                 790                 795                 800 


Ser Tyr Glu Glu Val His Arg Met Leu Gln Leu Ala Ile Ser Glu Gly 
                805                 810                 815     


Cys Glu Gly Phe Gly Met Leu 
            820             


<210>  795
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  795

Met Leu Cys Gly Arg Pro Arg Ser Ser Ser Asp Asn Arg Asn Phe Leu 
1               5                   10                  15      


Arg Glu Arg Ala Gly Leu Ser Ser Ala Ala Val Gln Thr Arg Ile Gly 
            20                  25                  30          


Asn Ser Ala Ala Ser Arg Arg Ser Pro Ala Ala Arg Pro Pro Val Pro 
        35                  40                  45              


Ala Pro Pro Ala Leu Pro Arg Gly Arg Pro Gly Thr Glu Gly Ser Thr 
    50                  55                  60                  


Ser Leu Ser Ala Pro Ala Val Leu Val Val Ala Val Ala Val Val Val 
65                  70                  75                  80  


Val Val Val Ser Ala Val Ala Trp Ala Met Ala Asn Tyr Ile His Val 
                85                  90                  95      


Pro Pro Gly Ser Pro Glu Val Pro Lys Leu Asn Val Thr Val Gln Asp 
            100                 105                 110         


Gln Glu Glu His Arg Cys Arg Glu Gly Ala Leu Ser Leu Leu Gln His 
        115                 120                 125             


Leu Arg Pro His Trp Asp Pro Gln Glu Val Thr Leu Gln Leu Phe Thr 
    130                 135                 140                 


Asp Gly Ile Thr Asn Lys Leu Ile Gly Cys Tyr Val Gly Asn Thr Met 
145                 150                 155                 160 


Glu Asp Val Val Leu Val Arg Ile Tyr Gly Asn Lys Thr Glu Leu Leu 
                165                 170                 175     


Val Asp Arg Asp Glu Glu Val Lys Ser Phe Arg Val Leu Gln Ala His 
            180                 185                 190         


Gly Cys Ala Pro Gln Leu Tyr Cys Thr Phe Asn Asn Gly Leu Cys Tyr 
        195                 200                 205             


Glu Phe Ile Gln Gly Glu Ala Leu Asp Pro Lys His Val Cys Asn Pro 
    210                 215                 220                 


Ala Ile Phe Ser Leu Ser Ser Leu Thr Leu Cys Lys Gly Lys Thr Thr 
225                 230                 235                 240 


Arg Cys Phe Gly Leu Thr Gly Cys Arg Gly Ser Arg Leu Leu Leu Ser 
                245                 250                 255     


Phe Phe 
        


<210>  796
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  796

Met Gly Glu Phe Asn Glu Lys Lys Thr Thr Cys Gly Thr Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Thr Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Thr Tyr Leu Ala Thr Ala Tyr Ile Leu 
    50                  55                  60                  


Val Val Ala Gly Thr Val Val Met Val Thr Gly Val Leu Gly Cys Cys 
65                  70                  75                  80  


Ala Thr Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu 
                85                  90                  95      


Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr 
            100                 105                 110         


Ala Tyr Tyr Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu Lys Asp 
        115                 120                 125             


Thr Met Thr Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Thr Ser 
    130                 135                 140                 


Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn 
145                 150                 155                 160 


Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly 
                165                 170                 175     


Gly Arg Val Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala Leu Cys 
            180                 185                 190         


Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly Gly Cys 
        195                 200                 205             


Ile Thr Lys Leu Glu Thr Phe Ile Gln Glu His Leu Arg Val Ile Gly 
    210                 215                 220                 


Ala Val Gly Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met Ile Phe 
225                 230                 235                 240 


Thr Cys Cys Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr 
                245                 250             


<210>  797
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  797

Met Pro Val Pro Ala Ser Trp Pro His Pro Pro Gly Pro Phe Leu Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Gly Leu Thr Glu Val Ala Gly Glu Glu Glu Leu 
            20                  25                  30          


Gln Met Ile Gln Pro Glu Lys Leu Leu Leu Val Thr Val Gly Lys Thr 
        35                  40                  45              


Ala Thr Leu His Cys Thr Val Thr Ser Leu Leu Pro Val Gly Pro Val 
    50                  55                  60                  


Leu Trp Phe Arg Gly Val Gly Pro Gly Arg Glu Leu Ile Tyr Asn Gln 
65                  70                  75                  80  


Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu Thr Lys 
                85                  90                  95      


Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Ser Ser Ile Thr Pro Ala 
            100                 105                 110         


Asp Val Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser Pro Glu 
        115                 120                 125             


Asn Val Glu Phe Lys Ser Gly Pro Gly Thr Glu Met Ala Leu Gly Ala 
    130                 135                 140                 


Lys Pro Ser Ala Pro Val Val Leu Gly Pro Ala Ala Arg Thr Thr Pro 
145                 150                 155                 160 


Glu His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro Arg 
                165                 170                 175     


Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp Phe 
            180                 185                 190         


Gln Thr Asn Val Asp Pro Thr Gly Gln Ser Val Ala Tyr Ser Ile Arg 
        195                 200                 205             


Ser Thr Ala Arg Val Val Leu Asp Pro Trp Asp Val Arg Ser Gln Val 
    210                 215                 220                 


Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg Gly 
225                 230                 235                 240 


Thr Ala Asn Leu Ser Glu Ala Ile Arg Gly Pro Ala Ser Ser Leu Thr 
                245                 250                 255     


Ala Leu Leu Leu Ile Ala Val Leu Leu Gly Pro Ile Tyr Val Pro Trp 
            260                 265                 270         


Lys Gln Lys Thr 
        275     


<210>  798
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  798

Met Glu Pro Trp Pro Leu Leu Leu Leu Phe Ser Leu Cys Ser Ala Gly 
1               5                   10                  15      


Leu Val Leu Gly Ser Glu His Glu Thr Arg Leu Val Ala Lys Leu Phe 
            20                  25                  30          


Lys Asp Tyr Ser Ser Val Val Arg Pro Val Glu Asp His Arg Gln Val 
        35                  40                  45              


Val Glu Val Thr Val Gly Leu Gln Leu Ile Gln Leu Ile Asn Val Asp 
    50                  55                  60                  


Glu Val Asn Gln Ile Val Thr Thr Asn Val Arg Leu Lys Gln Gly Asp 
65                  70                  75                  80  


Met Val Asp Leu Pro Arg Pro Ser Cys Val Thr Leu Gly Val Pro Leu 
                85                  90                  95      


Phe Ser His Leu Gln Asn Glu Gln Trp Val Asp Tyr Asn Leu Lys Trp 
            100                 105                 110         


Asn Pro Asp Asp Tyr Gly Gly Val Lys Lys Ile His Ile Pro Ser Glu 
        115                 120                 125             


Lys Ile Trp Arg Pro Asp Leu Val Leu Tyr Asn Asn Ala Asp Gly Asp 
    130                 135                 140                 


Phe Ala Ile Val Lys Phe Thr Lys Val Leu Leu Gln Tyr Thr Gly His 
145                 150                 155                 160 


Ile Thr Trp Thr Pro Pro Ala Ile Phe Lys Ser Tyr Cys Glu Ile Ile 
                165                 170                 175     


Val Thr His Phe Pro Phe Asp Glu Gln Asn Cys Ser Met Lys Leu Gly 
            180                 185                 190         


Thr Trp Thr Tyr Asp Gly Ser Val Val Ala Ile Asn Pro Glu Ser Asp 
        195                 200                 205             


Gln Pro Asp Leu Ser Asn Phe Met Glu Ser Gly Glu Trp Val Ile Lys 
    210                 215                 220                 


Glu Ser Arg Gly Trp Lys His Ser Val Thr Tyr Ser Cys Cys Pro Asp 
225                 230                 235                 240 


Thr Pro Tyr Leu Asp Ile Thr Tyr His Phe Val Met Gln Arg Leu Pro 
                245                 250                 255     


Leu Tyr Phe Ile Val Asn Val Ile Ile Pro Cys Leu Leu Phe Ser Phe 
            260                 265                 270         


Leu Thr Gly Leu Val Phe Tyr Leu Pro Thr Asp Ser Gly Glu Lys Met 
        275                 280                 285             


Thr Leu Ser Ile Ser Val Leu Leu Ser Leu Thr Val Phe Leu Leu Val 
    290                 295                 300                 


Ile Val Glu Leu Ile Pro Ser Thr Ser Ser Ala Val Pro Leu Ile Gly 
305                 310                 315                 320 


Lys Tyr Met Leu Phe Thr Met Val Phe Val Ile Ala Ser Ile Ile Ile 
                325                 330                 335     


Thr Val Ile Val Ile Asn Thr His His Arg Ser Pro Ser Thr His Val 
            340                 345                 350         


Met Pro Asn Trp Val Arg Lys Val Phe Ile Asp Thr Ile Pro Asn Ile 
        355                 360                 365             


Met Phe Phe Ser Thr Met Lys Arg Pro Ser Arg Glu Lys Gln Asp Lys 
    370                 375                 380                 


Lys Ile Phe Thr Glu Asp Ile Asp Ile Ser Asp Ile Ser Gly Lys Pro 
385                 390                 395                 400 


Gly Pro Pro Pro Met Gly Phe His Ser Pro Leu Ile Lys His Pro Glu 
                405                 410                 415     


Val Lys Ser Ala Ile Glu Gly Ile Lys Tyr Ile Ala Glu Thr Met Lys 
            420                 425                 430         


Ser Asp Gln Glu Ser Asn Asn Ala Ala Ala Glu Trp Lys Tyr Val Ala 
        435                 440                 445             


Met Val Met Asp His Ile Leu Leu Gly Val Phe Met Leu Val Cys Ile 
    450                 455                 460                 


Ile Gly Thr Leu Ala Val Phe Ala Gly Arg Leu Ile Glu Leu Asn Gln 
465                 470                 475                 480 


Gln Gly 
        


<210>  799
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  799

Met Ala Pro Pro Ala Ala Arg Leu Ala Leu Leu Ser Ala Ala Ala Leu 
1               5                   10                  15      


Thr Leu Ala Ala Arg Pro Ala Pro Ser Pro Gly Leu Gly Pro Gly Pro 
            20                  25                  30          


Glu Cys Phe Thr Ala Asn Gly Ala Asp Tyr Arg Gly Thr Gln Asn Trp 
        35                  40                  45              


Thr Ala Leu Gln Gly Gly Lys Pro Cys Leu Phe Trp Asn Glu Thr Phe 
    50                  55                  60                  


Gln His Pro Tyr Asn Thr Leu Lys Tyr Pro Asn Gly Glu Gly Gly Leu 
65                  70                  75                  80  


Gly Glu His Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Ser Pro Trp 
                85                  90                  95      


Cys Tyr Val Ala Glu His Glu Asp Gly Val Tyr Trp Lys Tyr Cys Glu 
            100                 105                 110         


Ile Pro Ala Cys Gln Met Pro Gly Asn Leu Gly Cys Tyr Lys Asp His 
        115                 120                 125             


Gly Asn Pro Pro Pro Leu Thr Gly Thr Ser Lys Thr Ser Asn Lys Leu 
    130                 135                 140                 


Thr Ile Gln Thr Cys Ile Ser Phe Cys Arg Ser Gln Arg Phe Lys Phe 
145                 150                 155                 160 


Ala Gly Met Glu Ser Gly Tyr Ala Cys Phe Cys Gly Asn Asn Pro Asp 
                165                 170                 175     


Tyr Trp Lys Tyr Gly Glu Ala Ala Ser Thr Glu Cys Asn Ser Val Cys 
            180                 185                 190         


Phe Gly Asp His Thr Gln Pro Cys Gly Gly Asp Gly Arg Ile Ile Leu 
        195                 200                 205             


Phe Asp Thr Leu Val Gly Ala Cys Gly Gly Asn Tyr Ser Ala Met Ser 
    210                 215                 220                 


Ser Val Val Tyr Ser Pro Asp Phe Pro Asp Thr Tyr Ala Thr Gly Arg 
225                 230                 235                 240 


Val Cys Tyr Trp Thr Ile Arg Val Pro Gly Ala Ser His Ile His Phe 
                245                 250                 255     


Ser Phe Pro Leu Phe Asp Ile Arg Asp Ser Ala Asp Met Val Glu Leu 
            260                 265                 270         


Leu Asp Gly Tyr Thr His Arg Val Leu Ala Arg Phe His Gly Arg Ser 
        275                 280                 285             


Arg Pro Pro Leu Ser Phe Asn Val Ser Leu Asp Phe Val Ile Leu Tyr 
    290                 295                 300                 


Phe Phe Ser Asp Arg Ile Asn Gln Ala Gln Gly Phe Ala Val Leu Tyr 
305                 310                 315                 320 


Gln Ala Val Lys Glu Glu Leu Pro Gln Glu Arg Pro Ala Val Asn Gln 
                325                 330                 335     


Thr Val Ala Glu Val Ile Thr Glu Gln Ala Asn Leu Ser Val Ser Ala 
            340                 345                 350         


Ala Arg Ser Ser Lys Val Leu Tyr Val Ile Thr Thr Ser Pro Ser His 
        355                 360                 365             


Pro Pro Gln Thr Val Pro Gly Trp Thr Val Tyr Gly Leu Ala Thr Leu 
    370                 375                 380                 


Leu Ile Leu Thr Val Thr Ala Ile Val Ala Lys Ile Leu Leu His Val 
385                 390                 395                 400 


Thr Phe Lys Ser His Arg Val Pro Ala Ser Gly Asp Leu Arg Asp Cys 
                405                 410                 415     


His Gln Pro Gly Thr Ser Gly Glu Ile Trp Ser Ile Phe Tyr Lys Pro 
            420                 425                 430         


Ser Thr Ser Ile Ser Ile Phe Lys Lys Lys Leu Lys Gly Gln Ser Gln 
        435                 440                 445             


Gln Asp Asp Arg Asn Pro Leu Val Ser Asp 
    450                 455             


<210>  800
<211>  626
<212>  PRT
<213>  Homo sapiens

<400>  800

Met Ile Ser Ser Val Cys Val Ser Ser Tyr Arg Gly Arg Lys Ser Gly 
1               5                   10                  15      


Asn Lys Pro Pro Ser Lys Thr Cys Leu Lys Glu Glu Met Ala Lys Gly 
            20                  25                  30          


Glu Ala Ser Glu Lys Ile Ile Ile Asn Val Gly Gly Thr Arg His Glu 
        35                  40                  45              


Thr Tyr Arg Ser Thr Leu Arg Thr Leu Pro Gly Thr Arg Leu Ala Trp 
    50                  55                  60                  


Leu Ala Asp Pro Asp Gly Gly Gly Arg Pro Glu Thr Asp Gly Gly Gly 
65                  70                  75                  80  


Val Gly Ser Ser Gly Ser Ser Gly Gly Gly Gly Cys Glu Phe Phe Phe 
                85                  90                  95      


Asp Arg His Pro Gly Val Phe Ala Tyr Val Leu Asn Tyr Tyr Arg Thr 
            100                 105                 110         


Gly Lys Leu His Cys Pro Ala Asp Val Cys Gly Pro Leu Phe Glu Glu 
        115                 120                 125             


Glu Leu Thr Phe Trp Gly Ile Asp Glu Thr Asp Val Glu Pro Cys Cys 
    130                 135                 140                 


Trp Met Thr Tyr Arg Gln His Arg Asp Ala Glu Glu Ala Leu Asp Ile 
145                 150                 155                 160 


Phe Glu Ser Pro Asp Gly Gly Gly Ser Gly Ala Gly Pro Ser Asp Glu 
                165                 170                 175     


Ala Gly Asp Asp Glu Arg Glu Leu Ala Leu Gln Arg Leu Gly Pro His 
            180                 185                 190         


Glu Gly Gly Ala Gly His Gly Ala Gly Ser Gly Gly Cys Arg Gly Trp 
        195                 200                 205             


Gln Pro Arg Met Trp Ala Leu Phe Glu Asp Pro Tyr Ser Ser Arg Ala 
    210                 215                 220                 


Ala Arg Val Val Ala Phe Ala Ser Leu Phe Phe Ile Leu Val Ser Ile 
225                 230                 235                 240 


Thr Thr Phe Cys Leu Glu Thr His Glu Ala Phe Asn Ile Asp Arg Asn 
                245                 250                 255     


Val Thr Glu Ile Leu Arg Val Gly Asn Ile Thr Ser Val His Phe Arg 
            260                 265                 270         


Arg Glu Val Glu Thr Glu Pro Ile Leu Thr Tyr Ile Glu Gly Val Cys 
        275                 280                 285             


Val Leu Trp Phe Thr Leu Glu Phe Leu Val Arg Ile Val Cys Cys Pro 
    290                 295                 300                 


Asp Thr Leu Asp Phe Val Lys Asn Leu Leu Asn Ile Ile Asp Phe Val 
305                 310                 315                 320 


Ala Ile Leu Pro Phe Tyr Leu Glu Val Gly Leu Ser Gly Leu Ser Ser 
                325                 330                 335     


Lys Ala Ala Arg Asp Val Leu Gly Phe Leu Arg Val Val Arg Phe Val 
            340                 345                 350         


Arg Ile Leu Arg Ile Phe Lys Leu Thr Arg His Phe Val Gly Leu Arg 
        355                 360                 365             


Val Leu Gly His Thr Leu Arg Ala Ser Thr Asn Glu Phe Leu Leu Leu 
    370                 375                 380                 


Ile Ile Phe Leu Ala Leu Gly Val Leu Ile Phe Ala Thr Met Ile Tyr 
385                 390                 395                 400 


Tyr Ala Glu Arg Ile Gly Ala Arg Pro Ser Asp Pro Arg Gly Asn Asp 
                405                 410                 415     


His Thr Asp Phe Lys Asn Ile Pro Ile Gly Phe Trp Trp Ala Val Val 
            420                 425                 430         


Thr Met Thr Thr Leu Gly Tyr Gly Asp Met Tyr Pro Lys Thr Trp Ser 
        435                 440                 445             


Gly Met Leu Val Gly Ala Leu Cys Ala Leu Ala Gly Val Leu Thr Ile 
    450                 455                 460                 


Ala Met Pro Val Pro Val Ile Val Asn Asn Phe Gly Met Tyr Tyr Ser 
465                 470                 475                 480 


Leu Ala Met Ala Lys Gln Lys Leu Pro Lys Lys Arg Lys Lys His Val 
                485                 490                 495     


Pro Arg Pro Ala Gln Leu Glu Ser Pro Met Tyr Cys Lys Ser Glu Glu 
            500                 505                 510         


Thr Ser Pro Arg Asp Ser Thr Cys Ser Asp Thr Ser Pro Pro Ala Arg 
        515                 520                 525             


Glu Glu Gly Met Ile Glu Arg Lys Arg Ala Asp Ser Lys Gln Asn Gly 
    530                 535                 540                 


Asp Ala Asn Ala Val Leu Ser Asp Glu Glu Gly Ala Gly Leu Thr Gln 
545                 550                 555                 560 


Pro Leu Ala Ser Ser Pro Thr Pro Glu Glu Arg Arg Ala Leu Arg Arg 
                565                 570                 575     


Ser Thr Thr Arg Asp Arg Asn Lys Lys Ala Ala Ala Cys Phe Leu Leu 
            580                 585                 590         


Ser Thr Gly Asp Tyr Ala Cys Ala Asp Gly Ser Val Arg Lys Glu Thr 
        595                 600                 605             


Cys Gln Asp Ala Leu Ser Ser Asn Tyr Ala Gln Ala Glu Val Leu Thr 
    610                 615                 620                 


Leu Ser 
625     


<210>  801
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  801

Met Ala Ala Ala Ala Ala Ala Ala Gly Ala Ala Gly Ser Ala Ala Pro 
1               5                   10                  15      


Ala Ala Ala Ala Gly Ala Pro Gly Ser Gly Gly Ala Pro Ser Gly Ser 
            20                  25                  30          


Gln Gly Val Leu Ile Gly Asp Arg Leu Tyr Ser Gly Val Leu Ile Thr 
        35                  40                  45              


Leu Glu Asn Cys Leu Leu Pro Asp Asp Lys Leu Arg Phe Thr Pro Ser 
    50                  55                  60                  


Met Ser Ser Gly Leu Asp Thr Asp Thr Glu Thr Asp Leu Arg Val Val 
65                  70                  75                  80  


Gly Cys Glu Leu Ile Gln Ala Ala Gly Ile Leu Leu Arg Leu Pro Gln 
                85                  90                  95      


Val Ala Met Ala Thr Gly Gln Val Leu Phe Gln Arg Phe Phe Tyr Thr 
            100                 105                 110         


Lys Ser Phe Val Lys His Ser Met Glu His Val Ser Met Ala Cys Val 
        115                 120                 125             


His Leu Ala Ser Lys Ile Glu Glu Ala Pro Arg Arg Ile Arg Asp Val 
    130                 135                 140                 


Ile Asn Val Phe His Arg Leu Arg Gln Leu Arg Asp Lys Lys Lys Pro 
145                 150                 155                 160 


Val Pro Leu Leu Leu Asp Gln Asp Tyr Val Asn Leu Lys Asn Gln Ile 
                165                 170                 175     


Ile Lys Ala Glu Arg Arg Val Leu Lys Glu Leu Gly Phe Cys Val His 
            180                 185                 190         


Val Lys His Pro His Lys Ile Ile Val Met Tyr Leu Gln Val Leu Glu 
        195                 200                 205             


Cys Glu Arg Asn Gln His Leu Val Gln Thr Ser Trp Val Ala Ser Glu 
    210                 215                 220                 


Gly Lys 
225     


<210>  802
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  802

Met Phe Ala Asp Leu Asp Tyr Asp Ile Glu Glu Asp Lys Leu Gly Ile 
1               5                   10                  15      


Pro Thr Val Pro Gly Lys Val Thr Leu Gln Lys Asp Ala Gln Asn Leu 
            20                  25                  30          


Ile Gly Ile Ser Ile Gly Gly Gly Ala Gln Tyr Cys Pro Cys Leu Tyr 
        35                  40                  45              


Ile Val Gln Val Phe Asp Asn Thr Pro Ala Ala Leu Asp Gly Thr Val 
    50                  55                  60                  


Ala Ala Gly Asp Glu Ile Thr Gly Val Asn Gly Arg Ser Ile Lys Gly 
65                  70                  75                  80  


Lys Thr Lys Val Glu Val Ala Lys Met Ile Gln Glu Val Lys Gly Glu 
                85                  90                  95      


Val Thr Ile His Tyr Asn Lys Leu Gln Ala Asp Pro Lys Gln Gly Met 
            100                 105                 110         


Ser Leu Asp Ile Val Leu Lys Lys Val Lys His Arg Leu Val Glu Asn 
        115                 120                 125             


Met Ser Ser Gly Thr Ala Asp Ala Leu Gly Leu Ser Arg Ala Ile Leu 
    130                 135                 140                 


Cys Asn Asp Gly Leu Val Lys Arg Leu Glu Glu Leu Glu Arg Thr Ala 
145                 150                 155                 160 


Glu Leu Tyr Lys Gly Met Thr Glu His Thr Lys Asn Leu Leu Arg Ala 
                165                 170                 175     


Phe Tyr Glu Leu Ser Gln Thr His Arg Ala Phe Gly Asp Val Phe Ser 
            180                 185                 190         


Val Ile Gly Val Arg Glu Pro Gln Pro Ala Ala Ser Glu Ala Phe Val 
        195                 200                 205             


Lys Phe Ala Asp Ala His Arg Ser Ile Glu Lys Phe Gly Ile Arg Leu 
    210                 215                 220                 


Leu Lys Thr Ile Lys Pro Met Leu Thr Asp Leu Asn Thr Tyr Leu Asn 
225                 230                 235                 240 


Lys Ala Ile Pro Asp Thr Arg Leu Thr Ile Lys Lys Tyr Leu Asp Val 
                245                 250                 255     


Lys Phe Glu Tyr Leu Ser Tyr Cys Leu Lys Val Lys Glu Met Asp Asp 
            260                 265                 270         


Glu Glu Tyr Ser Cys Ile Ala Leu Gly Glu Pro Leu Tyr Arg Val Ser 
        275                 280                 285             


Thr Gly Asn Tyr Glu Tyr Arg Leu Ile Leu Arg Cys Arg Gln Glu Ala 
    290                 295                 300                 


Arg Ala Arg Phe Ser Gln Met Arg Lys Asp Val Leu Glu Lys Met Glu 
305                 310                 315                 320 


Leu Leu Asp Gln Lys His Val Gln Asp Ile Val Phe Gln Leu Gln Arg 
                325                 330                 335     


Leu Val Ser Thr Met Ser Lys Tyr Tyr Asn Asp Cys Tyr Ala Val Leu 
            340                 345                 350         


Arg Asp Ala Asp Val Phe Pro Ile Glu Val Asp Leu Ala His Thr Thr 
        355                 360                 365             


Leu Ala Tyr Gly Leu Asn Gln Glu Glu Phe Thr Asp Gly Glu Glu Glu 
    370                 375                 380                 


Glu Glu Glu Glu Asp Thr Ala Ala Gly Glu Pro Ser Arg Asp Thr Arg 
385                 390                 395                 400 


Gly Ala Ala Gly Pro Leu Asp Lys Gly Gly Ser Trp Cys Asp Ser 
                405                 410                 415 


<210>  803
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  803

Met Phe Ala Asp Leu Asp Tyr Asp Ile Glu Glu Asp Lys Leu Gly Ile 
1               5                   10                  15      


Pro Thr Val Pro Gly Lys Val Thr Leu Gln Lys Asp Ala Gln Asn Leu 
            20                  25                  30          


Ile Gly Ile Ser Ile Gly Gly Gly Ala Gln Tyr Cys Pro Cys Leu Tyr 
        35                  40                  45              


Ile Val Gln Val Phe Asp Asn Thr Pro Ala Ala Leu Asp Gly Thr Val 
    50                  55                  60                  


Ala Ala Gly Asp Glu Ile Thr Gly Val Asn Gly Arg Ser Ile Lys Gly 
65                  70                  75                  80  


Lys Thr Lys Val Glu Val Ala Lys Met Ile Gln Glu Val Lys Gly Glu 
                85                  90                  95      


Val Thr Ile His Tyr Asn Lys Leu Gln Ala Asp Pro Lys Gln Gly Met 
            100                 105                 110         


Ser Leu Asp Ile Val Leu Lys Lys Val Lys His Arg Leu Val Glu Asn 
        115                 120                 125             


Met Ser Ser Gly Thr Ala Asp Ala Leu Gly Leu Ser Arg Ala Ile Leu 
    130                 135                 140                 


Cys Asn Asp Gly Leu Val Lys Arg Leu Glu Glu Leu Glu Arg Thr Ala 
145                 150                 155                 160 


Glu Leu Tyr Lys Gly Met Thr Glu His Thr Lys Asn Leu Leu Arg Ala 
                165                 170                 175     


Phe Tyr Glu Leu Ser Gln Thr His Arg Ala Phe Gly Asp Val Phe Ser 
            180                 185                 190         


Val Ile Gly Val Arg Glu Pro Gln Pro Ala Ala Ser Glu Ala Phe Val 
        195                 200                 205             


Lys Phe Ala Asp Ala His Arg Ser Ile Glu Lys Phe Gly Ile Arg Leu 
    210                 215                 220                 


Leu Lys Thr Ile Lys Pro Met Leu Thr Asp Leu Asn Thr Tyr Leu Asn 
225                 230                 235                 240 


Lys Ala Ile Pro Asp Thr Arg Leu Thr Ile Lys Lys Tyr Leu Asp Val 
                245                 250                 255     


Lys Phe Glu Tyr Leu Ser Tyr Cys Leu Lys Val Lys Glu Met Asp Asp 
            260                 265                 270         


Glu Glu Tyr Ser Cys Ile Ala Leu Gly Glu Pro Leu Tyr Arg Val Ser 
        275                 280                 285             


Thr Gly Asn Tyr Glu Tyr Arg Leu Ile Leu Arg Cys Arg Gln Glu Ala 
    290                 295                 300                 


Arg Ala Arg Phe Ser Gln Met Arg Lys Asp Val Leu Glu Lys Met Glu 
305                 310                 315                 320 


Leu Leu Asp Gln Lys His Val Gln Asp Ile Val Phe Gln Leu Gln Arg 
                325                 330                 335     


Leu Val Ser Thr Met Ser Lys Tyr Tyr Asn Asp Cys Tyr Ala Val Leu 
            340                 345                 350         


Arg Asp Ala Asp Val Phe Pro Ile Glu Val Asp Leu Ala His Thr Thr 
        355                 360                 365             


Leu Ala Tyr Gly Leu Asn Gln Glu Glu Phe Thr Asp Gly Glu Glu Glu 
    370                 375                 380                 


Glu Glu Glu Glu Asp Thr Ala Ala Gly Glu Pro Ser Arg Asp Thr Arg 
385                 390                 395                 400 


Gly Ala Ala Gly Pro Leu Asp Lys Gly Gly Ser Trp Cys Asp Ser 
                405                 410                 415 


<210>  804
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  804

Met Ser Met Asn Asn Ser Lys Gln Leu Val Ser Pro Ala Ala Ala Leu 
1               5                   10                  15      


Leu Ser Asn Thr Thr Cys Gln Thr Glu Asn Arg Leu Ser Val Phe Phe 
            20                  25                  30          


Ser Val Ile Phe Met Thr Val Gly Ile Leu Ser Asn Ser Leu Ala Ile 
        35                  40                  45              


Ala Ile Leu Met Lys Ala Tyr Gln Arg Phe Arg Gln Lys Ser Lys Ala 
    50                  55                  60                  


Ser Phe Leu Leu Leu Ala Ser Gly Leu Val Ile Thr Asp Phe Phe Gly 
65                  70                  75                  80  


His Leu Ile Asn Gly Ala Ile Ala Val Phe Val Tyr Ala Ser Asp Lys 
                85                  90                  95      


Glu Trp Ile Arg Phe Asp Gln Ser Asn Val Leu Cys Ser Ile Phe Gly 
            100                 105                 110         


Ile Cys Met Val Phe Ser Gly Leu Cys Pro Leu Leu Leu Gly Ser Val 
        115                 120                 125             


Met Ala Ile Glu Arg Cys Ile Gly Val Thr Lys Pro Ile Phe His Ser 
    130                 135                 140                 


Thr Lys Ile Thr Ser Lys His Val Lys Met Met Leu Ser Gly Val Cys 
145                 150                 155                 160 


Leu Phe Ala Val Phe Ile Ala Leu Leu Pro Ile Leu Gly His Arg Asp 
                165                 170                 175     


Tyr Lys Ile Gln Ala Ser Arg Thr Trp Cys Phe Tyr Asn Thr Glu Asp 
            180                 185                 190         


Ile Lys Asp Trp Glu Asp Arg Phe Tyr Leu Leu Leu Phe Ser Phe Leu 
        195                 200                 205             


Gly Leu Leu Ala Leu Gly Val Ser Leu Leu Cys Asn Ala Ile Thr Gly 
    210                 215                 220                 


Ile Thr Leu Leu Arg Val Lys Phe Lys Ser Gln Gln His Arg Gln Gly 
225                 230                 235                 240 


Arg Ser His His Leu Glu Met Val Ile Gln Leu Leu Ala Ile Met Cys 
                245                 250                 255     


Val Ser Cys Ile Cys Trp Ser Pro Phe Leu Gly Tyr Arg Ile Ile Leu 
            260                 265                 270         


Asn Gly Lys Glu Lys Tyr Lys Val Tyr Glu Glu Gln Ser Asp Phe Leu 
        275                 280                 285             


His Arg Leu Gln Trp Pro Thr Leu Glu 
    290                 295         


<210>  805
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  805

Met Thr Leu Leu Thr Asp Ala Thr Pro Leu Val Lys Glu Pro His Pro 
1               5                   10                  15      


Leu Pro Leu Val Pro Arg Pro Trp Phe Leu Pro Ser Leu Phe Ala Ala 
            20                  25                  30          


Phe Asn Val Val Leu Leu Val Phe Phe Ser Gly Leu Phe Phe Ala Phe 
        35                  40                  45              


Pro Cys Arg Trp Leu Ala Gln Asn Gly Glu Trp Ala Phe Pro Val Ile 
    50                  55                  60                  


Thr Gly Ser Leu Phe Val Leu Thr Phe Phe Ser Leu Val Ser Leu Asn 
65                  70                  75                  80  


Phe Ser Asp Pro Gly Ile Leu His Gln Gly Ser Ala Glu Gln Gly Pro 
                85                  90                  95      


Leu Thr Val His Val Val Trp Val Asn His Gly Ala Phe Arg Leu Gln 
            100                 105                 110         


Trp Cys Pro Lys Cys Cys Phe His Arg Pro Pro Arg Thr Tyr His Cys 
        115                 120                 125             


Pro Trp Cys Asn Ile Cys Val Glu Asp Phe Asp His His Cys Lys Trp 
    130                 135                 140                 


Val Asn Asn Cys Ile Gly His Arg Asn Phe Arg Phe Phe Met Leu Leu 
145                 150                 155                 160 


Val Leu Ser Leu Cys Leu Tyr Ser Gly Ala Met Leu Val Thr Cys Leu 
                165                 170                 175     


Ile Phe Leu Val Arg Thr Thr His Leu Pro Phe Ser Thr Asp Lys Ala 
            180                 185                 190         


Ile Ala Ile Val Val Ala Val Ser Ala Ala Gly Leu Leu Val Pro Leu 
        195                 200                 205             


Ser Leu Leu Leu Leu Ile Gln Ala Leu Ser Val Ser Ser Ala Asp Arg 
    210                 215                 220                 


Thr Tyr Lys Gly Lys Cys Arg His Leu Gln Gly Tyr Asn Pro Phe Asp 
225                 230                 235                 240 


Gln Gly Cys Ala Ser Asn Trp Tyr Leu Thr Ile Cys Ala Pro Leu Gly 
                245                 250                 255     


Pro Lys Tyr Met Ala Glu Ala Val Gln Leu Gln Arg Val Val Gly Pro 
            260                 265                 270         


Asp Trp Thr Ser Met Pro Asn Leu His Pro Pro Met Ser Pro Ser Ala 
        275                 280                 285             


Leu Asn Pro Pro Ala Pro Thr Ser Gly Ser Leu Gln Ser Arg Glu Gly 
    290                 295                 300                 


Thr Pro Gly Ala Trp 
305                 


<210>  806
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  806

Met Glu Gln Arg Pro Arg Gly Cys Ala Ala Val Ala Ala Ala Leu Leu 
1               5                   10                  15      


Leu Val Leu Leu Gly Ala Arg Ala Gln Gly Gly Thr Arg Ser Pro Arg 
            20                  25                  30          


Cys Asp Cys Ala Gly Asp Phe His Lys Lys Ile Gly Leu Phe Cys Cys 
        35                  40                  45              


Arg Gly Cys Pro Ala Gly His Tyr Leu Lys Ala Pro Cys Thr Glu Pro 
    50                  55                  60                  


Cys Gly Asn Ser Thr Cys Leu Val Cys Pro Gln Asp Thr Phe Leu Ala 
65                  70                  75                  80  


Trp Glu Asn His His Asn Ser Glu Cys Ala Arg Cys Gln Ala Cys Asp 
                85                  90                  95      


Glu Gln Ala Ser Gln Val Ala Leu Glu Asn Cys Ser Ala Val Ala Asp 
            100                 105                 110         


Thr Arg Cys Gly Cys Lys Pro Gly Trp Phe Val Glu Cys Gln Val Ser 
        115                 120                 125             


Gln Cys Val Ser Ser Ser Pro Phe Tyr Cys Gln Pro Cys Leu Asp Cys 
    130                 135                 140                 


Gly Ala Leu His Arg His Thr Arg Leu Leu Cys Ser Arg Arg Asp Thr 
145                 150                 155                 160 


Asp Cys Gly Thr Cys Leu Pro Gly Phe Tyr Glu His Gly Asp Gly Cys 
                165                 170                 175     


Val Ser Cys Pro Thr 
            180     


<210>  807
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  807

Met Pro Gly Ser Ala Ser Lys Arg Arg Ile Pro Val Ser Gln Pro Gly 
1               5                   10                  15      


Met Ala Asp Pro His Gln Leu Phe Asp Asp Thr Ser Ser Ala Gln Ser 
            20                  25                  30          


Arg Gly Tyr Gly Ala Gln Arg Ala Pro Gly Gly Leu Ser Tyr Pro Ala 
        35                  40                  45              


Ala Ser Pro Thr Pro His Ala Ala Phe Leu Ala Asp Pro Val Ser Asn 
    50                  55                  60                  


Met Ala Met Ala Tyr Gly Ser Ser Leu Ala Ala Gln Gly Lys Glu Leu 
65                  70                  75                  80  


Val Asp Lys Asn Ile Asp Arg Phe Ile Pro Ile Thr Lys Leu Lys Tyr 
                85                  90                  95      


Tyr Phe Ala Val Asp Thr Met Tyr Val Gly Arg Lys Leu Gly Leu Leu 
            100                 105                 110         


Phe Phe Pro Tyr Leu His Gln Asp Trp Glu Val Gln Tyr Gln Gln Asp 
        115                 120                 125             


Thr Pro Val Ala Pro Arg Phe Asp Val Asn Ala Pro Asp Leu Tyr Ile 
    130                 135                 140                 


Pro Ala Met Ala Phe Ile Thr Tyr Val Leu Val Ala Gly Leu Ala Leu 
145                 150                 155                 160 


Gly Thr Gln Asp Arg Phe Ser Pro Asp Leu Leu Gly Leu Gln Ala Ser 
                165                 170                 175     


Ser Ala Leu Ala Trp Leu Thr Leu Glu Val Leu Ala Ile Leu Leu Ser 
            180                 185                 190         


Leu Tyr Leu Val Thr Val Asn Thr Asp Leu Thr Thr Ile Asp Leu Val 
        195                 200                 205             


Ala Phe Leu Gly Tyr Lys Tyr Val Gly Met Ile Gly Gly Val Leu Met 
    210                 215                 220                 


Gly Leu Leu Phe Gly Lys Ile Gly Tyr Tyr Leu Val Leu Gly Trp Cys 
225                 230                 235                 240 


Cys Val Ala Ile Phe Val Phe Met Ile Arg Thr Leu Arg Leu Lys Ile 
                245                 250                 255     


Leu Ala Asp Ala Ala Ala Glu Gly Val Pro Val Arg Gly Ala Arg Asn 
            260                 265                 270         


Gln Leu Arg Met Tyr Leu Thr Met Ala Val Ala Ala Ala Gln Pro Met 
        275                 280                 285             


Leu Met Tyr Trp Leu Thr Phe His Leu Val Arg 
    290                 295                 


<210>  808
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  808

Met His Pro Ala Gly Leu Ala Ala Ala Ala Ala Gly Thr Pro Arg Leu 
1               5                   10                  15      


Arg Lys Trp Pro Ser Lys Arg Arg Ile Pro Val Ser Gln Pro Gly Met 
            20                  25                  30          


Ala Asp Pro His Gln Leu Phe Asp Asp Thr Ser Ser Ala Gln Ser Arg 
        35                  40                  45              


Gly Tyr Gly Ala Gln Arg Ala Pro Gly Gly Leu Ser Tyr Pro Ala Ala 
    50                  55                  60                  


Ser Pro Thr Pro His Ala Ala Phe Leu Ala Asp Pro Val Ser Asn Met 
65                  70                  75                  80  


Ala Met Ala Tyr Gly Ser Ser Leu Ala Ala Gln Gly Lys Glu Leu Val 
                85                  90                  95      


Asp Lys Asn Ile Asp Arg Phe Ile Pro Ile Thr Lys Leu Lys Tyr Tyr 
            100                 105                 110         


Phe Ala Val Asp Thr Met Tyr Val Gly Arg Lys Leu Gly Leu Leu Phe 
        115                 120                 125             


Phe Pro Tyr Leu His Gln Asp Trp Glu Val Gln Tyr Gln Gln Asp Thr 
    130                 135                 140                 


Pro Val Ala Pro Arg Phe Asp Val Asn Ala Pro Asp Leu Tyr Ile Pro 
145                 150                 155                 160 


Ala Met Ala Phe Ile Thr Tyr Val Leu Val Ala Gly Leu Ala Leu Gly 
                165                 170                 175     


Thr Gln Asp Arg Phe Ser Pro Asp Leu Leu Gly Leu Gln Ala Ser Ser 
            180                 185                 190         


Ala Leu Ala Trp Leu Thr Leu Glu Val Leu Ala Ile Leu Leu Ser Leu 
        195                 200                 205             


Tyr Leu Val Thr Val Asn Thr Asp Leu Thr Thr Ile Asp Leu Val Ala 
    210                 215                 220                 


Phe Leu Gly Tyr Lys Tyr Val Gly Met Ile Gly Gly Val Leu Met Gly 
225                 230                 235                 240 


Leu Leu Phe Gly Lys Ile Gly Tyr Tyr Leu Val Leu Gly Trp Cys Cys 
                245                 250                 255     


Val Ala Ile Phe Val Phe Met Ile Arg Thr Leu Arg Leu Lys Ile Leu 
            260                 265                 270         


Ala Asp Ala Ala Ala Glu Gly Val Pro Val Arg Gly Ala Arg Asn Gln 
        275                 280                 285             


Leu Arg Met Tyr Leu Thr Met Ala Val Ala Ala Ala Gln Pro Met Leu 
    290                 295                 300                 


Met Tyr Trp Leu Thr Phe His Leu Val Arg 
305                 310                 


<210>  809
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  809

Met His Pro Ala Gly Leu Ala Ala Ala Ala Ala Gly Thr Pro Arg Leu 
1               5                   10                  15      


Pro Ser Lys Arg Arg Ile Pro Val Ser Gln Pro Gly Met Ala Asp Pro 
            20                  25                  30          


His Gln Leu Phe Asp Asp Thr Ser Ser Ala Gln Ser Arg Gly Tyr Gly 
        35                  40                  45              


Ala Gln Arg Ala Pro Gly Gly Leu Ser Tyr Pro Ala Ala Ser Pro Thr 
    50                  55                  60                  


Pro His Ala Ala Phe Leu Ala Asp Pro Val Ser Asn Met Ala Met Ala 
65                  70                  75                  80  


Tyr Gly Ser Ser Leu Ala Ala Gln Gly Lys Glu Leu Val Asp Lys Asn 
                85                  90                  95      


Ile Asp Arg Phe Ile Pro Ile Thr Lys Leu Lys Tyr Tyr Phe Ala Val 
            100                 105                 110         


Asp Thr Met Tyr Val Gly Arg Lys Leu Gly Leu Leu Phe Phe Pro Tyr 
        115                 120                 125             


Leu His Gln Asp Trp Glu Val Gln Tyr Gln Gln Asp Thr Pro Val Ala 
    130                 135                 140                 


Pro Arg Phe Asp Val Asn Ala Pro Asp Leu Tyr Ile Pro Ala Met Ala 
145                 150                 155                 160 


Phe Ile Thr Tyr Val Leu Val Ala Gly Leu Ala Leu Gly Thr Gln Asp 
                165                 170                 175     


Arg Phe Ser Pro Asp Leu Leu Gly Leu Gln Ala Ser Ser Ala Leu Ala 
            180                 185                 190         


Trp Leu Thr Leu Glu Val Leu Ala Ile Leu Leu Ser Leu Tyr Leu Val 
        195                 200                 205             


Thr Val Asn Thr Asp Leu Thr Thr Ile Asp Leu Val Ala Phe Leu Gly 
    210                 215                 220                 


Tyr Lys Tyr Val Gly Met Ile Gly Gly Val Leu Met Gly Leu Leu Phe 
225                 230                 235                 240 


Gly Lys Ile Gly Tyr Tyr Leu Val Leu Gly Trp Cys Cys Val Ala Ile 
                245                 250                 255     


Phe Val Phe Met Ile Arg Thr Leu Arg Leu Lys Ile Leu Ala Asp Ala 
            260                 265                 270         


Ala Ala Glu Gly Val Pro Val Arg Gly Ala Arg Asn Gln Leu Arg Met 
        275                 280                 285             


Tyr Leu Thr Met Ala Val Ala Ala Ala Gln Pro Met Leu Met Tyr Trp 
    290                 295                 300                 


Leu Thr Phe His Leu Val Arg 
305                 310     


<210>  810
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  810

Met Gly Leu Pro Gln Pro Gly Leu Trp Leu Lys Arg Leu Trp Val Leu 
1               5                   10                  15      


Leu Glu Val Ala Val His Val Val Val Gly Lys Val Leu Leu Ile Leu 
            20                  25                  30          


Phe Pro Asp Arg Val Lys Arg Asn Ile Leu Ala Met Gly Glu Lys Thr 
        35                  40                  45              


Gly Met Thr Arg Asn Pro His Phe Ser His Asp Asn Trp Ile Pro Thr 
    50                  55                  60                  


Phe Phe Ser Thr Gln Tyr Phe Trp Phe Val Leu Lys Val Arg Trp Gln 
65                  70                  75                  80  


Arg Leu Glu Asp Thr Thr Glu Leu Gly Gly Leu Ala Pro Asn Cys Pro 
                85                  90                  95      


Val Val Arg Leu Ser Gly Gln Arg Cys Asn Ile Trp Glu Phe Met Gln 
            100                 105                 110         


Asp Gly Trp Ala Phe Lys Asn Asn Met Asp Ile Arg Asn His Gln Asn 
        115                 120                 125             


Leu Gln Asp Arg Leu Gln Ala Ala His Leu Leu Leu Ala Arg Ser Pro 
    130                 135                 140                 


Gln Cys Pro Val Val Val Asp Thr Met Gln Asn Gln Ser Ser Gln Leu 
145                 150                 155                 160 


Tyr Ala Ala Leu Pro Glu Arg Leu Tyr Ile Ile Gln Glu Gly Arg Ile 
                165                 170                 175     


Leu Tyr Lys Gly Lys Ser Gly Pro Trp Asn Tyr Asn Pro Glu Glu Val 
            180                 185                 190         


Arg Ala Val Leu Glu Lys Leu His Ser 
        195                 200     


<210>  811
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  811

Met Gly Leu Pro Gln Pro Gly Leu Trp Leu Lys Arg Leu Trp Val Leu 
1               5                   10                  15      


Leu Glu Val Ala Val His Val Val Val Gly Lys Val Leu Leu Ile Leu 
            20                  25                  30          


Phe Pro Asp Arg Val Lys Arg Asn Ile Leu Ala Met Gly Glu Lys Thr 
        35                  40                  45              


Gly Met Thr Arg Asn Pro His Phe Ser His Asp Asn Trp Ile Pro Thr 
    50                  55                  60                  


Phe Phe Ser Thr Gln Tyr Phe Trp Phe Val Leu Lys Val Arg Trp Gln 
65                  70                  75                  80  


Arg Leu Glu Asp Thr Thr Glu Leu Gly Gly Leu Ala Pro Asn Cys Pro 
                85                  90                  95      


Val Val Arg Leu Ser Gly Gln Arg Cys Asn Ile Trp Glu Phe Met Gln 
            100                 105                 110         


Gly Asn Arg Pro Leu Val Leu Asn Phe Gly Ser Cys Thr Pro Ser Phe 
        115                 120                 125             


Met Phe Lys Phe Asp Gln Phe Lys Arg Leu Ile Glu Asp Phe Ser Ser 
    130                 135                 140                 


Ile Ala Asp Phe Leu Val Ile Tyr Ile Glu Glu Ala His Ala Ser Gly 
145                 150                 155                 160 


<210>  812
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  812

Met Leu Gly Leu Leu Gly Ser Thr Ala Leu Val Gly Trp Ile Thr Gly 
1               5                   10                  15      


Ala Ala Val Ala Val Leu Leu Leu Leu Leu Leu Leu Ala Thr Cys Leu 
            20                  25                  30          


Phe His Gly Arg Gln Asp Cys Asp Val Glu Arg Asn Arg Thr Ala Ala 
        35                  40                  45              


Gly Gly Asn Arg Val Arg Arg Ala Gln Pro Trp Pro Phe Arg Arg Arg 
    50                  55                  60                  


Gly His Leu Gly Ile Phe His His His Arg His Pro Gly His Val Ser 
65                  70                  75                  80  


His Val Pro Asn Val Gly Leu His His His His His Pro Arg His Thr 
                85                  90                  95      


Pro His His Leu His His His His His Pro His Arg His His Pro Arg 
            100                 105                 110         


His Ala Arg 
        115 


<210>  813
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  813

Met Ser Ile Leu Leu Pro Asn Met Ala Glu Phe Asp Thr Ile Ser Glu 
1               5                   10                  15      


Leu Glu Glu Glu Glu Glu Glu Glu Ala Ala Thr Ser Ser Ser Ser Pro 
            20                  25                  30          


Ser Ser Ser Ser Ser Val Ser Gly Pro Asp Asp Asp Glu Glu Asp Glu 
        35                  40                  45              


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
    50                  55                  60                  


Glu Glu Glu Glu Ala Pro Pro Pro Pro Arg Val Val Ser Glu Glu His 
65                  70                  75                  80  


Leu Arg Arg Tyr Ala Pro Asp Pro Val Leu Val Arg Gly Ala Gly His 
                85                  90                  95      


Ile Thr Val Phe Gly Leu Ser Asn Lys Phe Asp Thr Glu Phe Pro Ser 
            100                 105                 110         


Val Leu Thr Gly Lys Val Ala Pro Glu Glu Phe Lys Thr Ser Ile Gly 
        115                 120                 125             


Arg Val Asn Ala Cys Leu Lys Lys Ala Leu Pro Val Asn Val Lys Trp 
    130                 135                 140                 


Leu Leu Cys Gly Cys Leu Cys Cys Cys Cys Thr Leu Gly Cys Ser Leu 
145                 150                 155                 160 


Trp Pro Val Ile Cys Leu Asn Lys Arg Thr Arg Arg Ser Ile Gln Lys 
                165                 170                 175     


Leu Ile Glu Trp Glu Asn Asn Arg Leu Tyr His Lys Leu Ala Leu His 
            180                 185                 190         


Trp Lys Leu Thr Lys Arg Lys Cys Glu Thr Ser Asn Met Met Glu Tyr 
        195                 200                 205             


Val Ile Leu Ile Glu Phe Leu Pro Lys Tyr Pro Ile Phe Arg Pro Asp 
    210                 215                 220                 


<210>  814
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  814

Met Ala Leu Ser Leu Pro Leu Gly Pro Arg Leu Gly Ser Glu Pro Leu 
1               5                   10                  15      


Asn His Pro Pro Gly Ala Pro Arg Glu Ala Asp Ile Val Gly Cys Thr 
            20                  25                  30          


Val Cys Pro Ala Ser Gly Glu Glu Ser Thr Ser Pro Glu Gln Ala Gln 
        35                  40                  45              


Thr Leu Gly Gln Asp Ser Leu Gly Pro Pro Glu His Phe Gln Gly Gly 
    50                  55                  60                  


Pro Arg Gly Asn Glu Pro Ala Ala His Pro Pro Arg Trp Ser Thr Pro 
65                  70                  75                  80  


Ser Ser Tyr Glu Asp Pro Ala Gly Gly Lys His Cys Glu His Pro Ile 
                85                  90                  95      


Ser Gly Leu Glu Val Leu Glu Ala Glu Gln Asn Ser Leu His Leu Cys 
            100                 105                 110         


Leu Leu Gly Leu Gly Arg Arg Leu Gln Asp Leu Glu Gln Gly Leu Gly 
        115                 120                 125             


His Trp Ala Leu Ala Gln Ser Gly Met Val Gln Leu Gln Ala Leu Gln 
    130                 135                 140                 


Val Asp Leu Arg Gly Ala Ala Glu Arg Val Glu Ala Leu Leu Ala Phe 
145                 150                 155                 160 


Gly Glu Gly Leu Ala Gln Arg Ser Glu Pro Arg Ala Trp Ala Ala Leu 
                165                 170                 175     


Glu Gln Ile Leu Arg Ala Leu Gly Ala Tyr Arg Asp Ser Ile Phe Arg 
            180                 185                 190         


Arg Leu Trp Gln Leu Gln Ala Gln Leu Val Ser Tyr Ser Leu Val Phe 
        195                 200                 205             


Glu Glu Ala Asn Thr Leu Asp Gln Asp Leu Glu Val Glu Gly Asp Ser 
    210                 215                 220                 


Asp Trp Pro Gly Pro Gly Gly Val Trp Gly Pro Trp Ala Pro Ser Ser 
225                 230                 235                 240 


Leu Pro Thr Ser Thr Glu Leu Glu Trp Asp Pro Ala Gly Asp Ile Gly 
                245                 250                 255     


Gly Leu Gly Pro Leu Gly Gln Lys Thr Ala Arg Thr Leu Gly Val Pro 
            260                 265                 270         


Cys Glu Leu Cys Gly Gln Arg Gly Pro Gln Gly Arg Gly Gln Gly Leu 
        275                 280                 285             


Glu Glu Ala Asp Thr Ser His Ser Arg Gln Asp Met Leu Glu Ser Gly 
    290                 295                 300                 


Leu Gly His Gln Lys Arg Leu Ala Arg His Gln Arg His Ser Leu Leu 
305                 310                 315                 320 


Arg Lys Pro Gln Asp Lys Lys Arg Gln Ala Ser Pro His Leu Gln Asp 
                325                 330                 335     


Val Arg Leu Glu Gly Asn Pro Gly Ala Pro Asp Pro Ala Ser Arg Gln 
            340                 345                 350         


Pro Leu Thr Phe Leu Leu Ile Leu Phe Leu Leu Phe Leu Leu Leu Val 
        355                 360                 365             


Gly Ala Met Phe Leu Leu Pro Ala Ser Gly Gly Pro Cys Cys Ser His 
    370                 375                 380                 


Ala Arg Ile Pro Arg Thr Pro Tyr Leu Val Leu Ser Tyr Val Asn Gly 
385                 390                 395                 400 


Leu Pro Pro Val 
                


<210>  815
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  815

Met Arg Leu Thr Arg Cys Gln Ala Ala Leu Ala Ala Ala Ile Thr Leu 
1               5                   10                  15      


Asn Leu Leu Val Leu Phe Tyr Val Ser Trp Leu Gln His Gln Pro Arg 
            20                  25                  30          


Asn Ser Arg Ala Arg Gly Pro Arg Arg Ala Ser Ala Ala Gly Pro Arg 
        35                  40                  45              


Val Thr Val Leu Val Arg Glu Phe Glu Ala Phe Asp Asn Ala Val Pro 
    50                  55                  60                  


Glu Leu Val Asp Ser Phe Leu Gln Gln Asp Pro Ala Gln Pro Val Val 
65                  70                  75                  80  


Val Ala Ala Asp Thr Leu Pro Tyr Pro Pro Leu Ala Leu Pro Arg Ile 
                85                  90                  95      


Pro Asn Val Arg Leu Ala Leu Leu Gln Pro Ala Leu Asp Arg Pro Ala 
            100                 105                 110         


Ala Ala Ser Arg Pro Glu Thr Tyr Val Ala Thr Glu Phe Val Ala Leu 
        115                 120                 125             


Val Pro Asp Gly Ala Arg Ala Glu Ala Pro Gly Leu Leu Glu Arg Met 
    130                 135                 140                 


Val Glu Ala Leu Arg Ala Gly Ser Ala Arg Leu Val Ala Ala Pro Val 
145                 150                 155                 160 


Ala Thr Ala Asn Pro Ala Arg Cys Leu Ala Leu Asn Val Ser Leu Arg 
                165                 170                 175     


Glu Trp Thr Ala Arg Tyr Gly Ala Ala Pro Ala Ala Pro Arg Cys Asp 
            180                 185                 190         


Ala Leu Asp Gly Asp Ala Val Val Leu Leu Arg Ala Arg Asp Leu Phe 
        195                 200                 205             


Asn Leu Ser Ala Pro Leu Ala Arg Pro Val Gly Thr Ser Leu Phe Leu 
    210                 215                 220                 


Gln Thr Ala Leu Arg Gly Trp Ala Val Gln Leu Leu Asp Leu Thr Phe 
225                 230                 235                 240 


Ala Ala Ala Arg Gln Pro Pro Leu Ala Thr Ala His Ala Arg Trp Lys 
                245                 250                 255     


Ala Glu Arg Glu Gly Arg Ala Arg Arg Ala Ala Leu Leu Arg Ala Leu 
            260                 265                 270         


Gly Ile Arg Leu Val Ser Trp Glu Gly Gly Arg Leu Glu Trp Phe Gly 
        275                 280                 285             


Cys Asn Lys Glu Thr Thr Arg Cys Phe Gly Thr Val Val Gly Asp Thr 
    290                 295                 300                 


Pro Ala Tyr Leu Tyr Glu Glu Arg Trp Thr Pro Pro Cys Cys Leu Arg 
305                 310                 315                 320 


Ala Leu Arg Glu Thr Ala Arg Tyr Val Val Gly Val Leu Glu Ala Ala 
                325                 330                 335     


Gly Val Arg Tyr Trp Leu Glu Gly Gly Ser Leu Leu Gly Ala Ala Arg 
            340                 345                 350         


His Gly Asp Ile Ile Pro Trp Asp Tyr Asp Val Asp Leu Gly Ile Tyr 
        355                 360                 365             


Leu Glu Asp Val Gly Asn Cys Glu Gln Leu Arg Gly Ala Glu Ala Gly 
    370                 375                 380                 


Ser Val Val Asp Glu Arg Gly Phe Val Trp Glu Lys Ala Val Glu Gly 
385                 390                 395                 400 


Asp Phe Phe Arg Val Gln Tyr Ser Glu Ser Asn His Leu His Val Asp 
                405                 410                 415     


Leu Trp Pro Phe Tyr Pro Arg Asn Gly Val Met Thr Lys Asp Thr Trp 
            420                 425                 430         


Leu Asp His Arg Gln Asp Val Glu Phe Pro Glu His Phe Leu Gln Pro 
        435                 440                 445             


Leu Val Pro Leu Pro Phe Ala Gly Phe Val Ala Gln Ala Pro Asn Asn 
    450                 455                 460                 


Tyr Arg Arg Phe Leu Glu Leu Lys Phe Gly Pro Gly Val Ile Glu Asn 
465                 470                 475                 480 


Pro Gln Tyr Pro Asn Pro Ala Leu Leu Ser Leu Thr Gly Ser Gly 
                485                 490                 495 


<210>  816
<211>  620
<212>  PRT
<213>  Homo sapiens

<400>  816

Met Ser Lys Ser Lys Cys Ser Val Gly Leu Met Ser Ser Val Val Ala 
1               5                   10                  15      


Pro Ala Lys Glu Pro Asn Ala Val Gly Pro Lys Glu Val Glu Leu Ile 
            20                  25                  30          


Leu Val Lys Glu Gln Asn Gly Val Gln Leu Thr Ser Ser Thr Leu Thr 
        35                  40                  45              


Asn Pro Arg Gln Ser Pro Val Glu Ala Gln Asp Arg Glu Thr Trp Gly 
    50                  55                  60                  


Lys Lys Ile Asp Phe Leu Leu Ser Val Ile Gly Phe Ala Val Asp Leu 
65                  70                  75                  80  


Ala Asn Val Trp Arg Phe Pro Tyr Leu Cys Tyr Lys Asn Gly Gly Gly 
                85                  90                  95      


Ala Phe Leu Val Pro Tyr Leu Leu Phe Met Val Ile Ala Gly Met Pro 
            100                 105                 110         


Leu Phe Tyr Met Glu Leu Ala Leu Gly Gln Phe Asn Arg Glu Gly Ala 
        115                 120                 125             


Ala Gly Val Trp Lys Ile Cys Pro Ile Leu Lys Gly Val Gly Phe Thr 
    130                 135                 140                 


Val Ile Leu Ile Ser Leu Tyr Val Gly Phe Phe Tyr Asn Val Ile Ile 
145                 150                 155                 160 


Ala Trp Ala Leu His Tyr Leu Phe Ser Ser Phe Thr Thr Glu Leu Pro 
                165                 170                 175     


Trp Ile His Cys Asn Asn Ser Trp Asn Ser Pro Asn Cys Ser Asp Ala 
            180                 185                 190         


His Pro Gly Asp Ser Ser Gly Asp Ser Ser Gly Leu Asn Asp Thr Phe 
        195                 200                 205             


Gly Thr Thr Pro Ala Ala Glu Tyr Phe Glu Arg Gly Val Leu His Leu 
    210                 215                 220                 


His Gln Ser His Gly Ile Asp Asp Leu Gly Pro Pro Arg Trp Gln Leu 
225                 230                 235                 240 


Thr Ala Cys Leu Val Leu Val Ile Val Leu Leu Tyr Phe Ser Leu Trp 
                245                 250                 255     


Lys Gly Val Lys Thr Ser Gly Lys Val Val Trp Ile Thr Ala Thr Met 
            260                 265                 270         


Pro Tyr Val Val Leu Thr Ala Leu Leu Leu Arg Gly Val Thr Leu Pro 
        275                 280                 285             


Gly Ala Ile Asp Gly Ile Arg Ala Tyr Leu Ser Val Asp Phe Tyr Arg 
    290                 295                 300                 


Leu Cys Glu Ala Ser Val Trp Ile Asp Ala Ala Thr Gln Val Cys Phe 
305                 310                 315                 320 


Ser Leu Gly Val Gly Phe Gly Val Leu Ile Ala Phe Ser Ser Tyr Asn 
                325                 330                 335     


Lys Phe Thr Asn Asn Cys Tyr Arg Asp Ala Ile Val Thr Thr Ser Ile 
            340                 345                 350         


Asn Ser Leu Thr Ser Phe Ser Ser Gly Phe Val Val Phe Ser Phe Leu 
        355                 360                 365             


Gly Tyr Met Ala Gln Lys His Ser Val Pro Ile Gly Asp Val Ala Lys 
    370                 375                 380                 


Asp Gly Pro Gly Leu Ile Phe Ile Ile Tyr Pro Glu Ala Ile Ala Thr 
385                 390                 395                 400 


Leu Pro Leu Ser Ser Ala Trp Ala Val Val Phe Phe Ile Met Leu Leu 
                405                 410                 415     


Thr Leu Gly Ile Asp Ser Ala Met Gly Gly Met Glu Ser Val Ile Thr 
            420                 425                 430         


Gly Leu Ile Asp Glu Phe Gln Leu Leu His Arg His Arg Glu Leu Phe 
        435                 440                 445             


Thr Leu Phe Ile Val Leu Ala Thr Phe Leu Leu Ser Leu Phe Cys Val 
    450                 455                 460                 


Thr Asn Gly Gly Ile Tyr Val Phe Thr Leu Leu Asp His Phe Ala Ala 
465                 470                 475                 480 


Gly Thr Ser Ile Leu Phe Gly Val Leu Ile Glu Ala Ile Gly Val Ala 
                485                 490                 495     


Trp Phe Tyr Gly Val Gly Gln Phe Ser Asp Asp Ile Gln Gln Met Thr 
            500                 505                 510         


Gly Gln Arg Pro Ser Leu Tyr Trp Arg Leu Cys Trp Lys Leu Val Ser 
        515                 520                 525             


Pro Cys Phe Leu Leu Phe Val Val Val Val Ser Ile Val Thr Phe Arg 
    530                 535                 540                 


Pro Pro His Tyr Gly Ala Tyr Ile Phe Pro Asp Trp Ala Asn Ala Leu 
545                 550                 555                 560 


Gly Trp Val Ile Ala Thr Ser Ser Met Ala Met Val Pro Ile Tyr Ala 
                565                 570                 575     


Ala Tyr Lys Phe Cys Ser Leu Pro Gly Ser Phe Arg Glu Lys Leu Ala 
            580                 585                 590         


Tyr Ala Ile Ala Pro Glu Lys Asp Arg Glu Leu Val Asp Arg Gly Glu 
        595                 600                 605             


Val Arg Gln Phe Thr Leu Arg His Trp Leu Lys Val 
    610                 615                 620 


<210>  817
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  817

Met Ala Arg Leu Ala Leu Ser Pro Val Pro Ser His Trp Met Val Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ser Ala Ala Glu Pro Val Pro Ala Ala Arg Ser 
            20                  25                  30          


Glu Asp Arg Tyr Arg Asn Pro Lys Gly Ser Ala Cys Ser Arg Ile Trp 
        35                  40                  45              


Gln Ser Pro Arg Phe Ile Ala Arg Lys Arg Gly Phe Thr Val Lys Met 
    50                  55                  60                  


His Cys Tyr Met Asn Ser Ala Ser Gly Asn Val Ser Trp Leu Trp Lys 
65                  70                  75                  80  


Gln Glu Met Asp Glu Asn Pro Gln Gln Leu Lys Leu Glu Lys Gly Arg 
                85                  90                  95      


Met Glu Glu Ser Gln Asn Glu Ser Leu Ala Thr Leu Thr Ile Gln Gly 
            100                 105                 110         


Ile Arg Phe Glu Asp Asn Gly Ile Tyr Phe Cys Gln Gln Lys Cys Asn 
        115                 120                 125             


Asn Thr Ser Glu Val Tyr Gln Gly Cys Gly Thr Glu Leu Arg Val Met 
    130                 135                 140                 


Gly Phe Ser Thr Leu Ala Gln Leu Lys Gln Arg Asn Thr Leu Lys Asp 
145                 150                 155                 160 


Gly Ile Ile Met Ile Gln Thr Leu Leu Ile Ile Leu Phe Ile Ile Val 
                165                 170                 175     


Pro Ile Phe Leu Leu Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu 
            180                 185                 190         


Glu Asp His Thr Tyr Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr 
        195                 200                 205             


Glu Asp Ile Val Thr Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly 
    210                 215                 220                 


Glu His Pro Gly Gln Glu 
225                 230 


<210>  818
<211>  1093
<212>  PRT
<213>  Homo sapiens

<400>  818

Met Pro Ala Ala Gly Ser Asn Glu Pro Asp Gly Val Leu Ser Tyr Gln 
1               5                   10                  15      


Arg Pro Asp Glu Glu Ala Val Val Asp Gln Gly Gly Thr Ser Thr Ile 
            20                  25                  30          


Leu Asn Ile His Tyr Glu Lys Glu Glu Leu Glu Gly His Arg Thr Leu 
        35                  40                  45              


Tyr Val Gly Val Arg Met Pro Leu Gly Arg Gln Ser His Arg His His 
    50                  55                  60                  


Arg Thr His Gly Gln Lys His Arg Arg Arg Gly Arg Gly Lys Gly Ala 
65                  70                  75                  80  


Ser Gln Gly Glu Glu Gly Leu Glu Ala Leu Ala His Asp Thr Pro Ser 
                85                  90                  95      


Gln Arg Val Gln Phe Ile Leu Gly Thr Glu Glu Asp Glu Glu His Val 
            100                 105                 110         


Pro His Glu Leu Phe Thr Glu Leu Asp Glu Ile Cys Met Lys Glu Gly 
        115                 120                 125             


Glu Asp Ala Glu Trp Lys Glu Thr Ala Arg Trp Leu Lys Phe Glu Glu 
    130                 135                 140                 


Asp Val Glu Asp Gly Gly Glu Arg Trp Ser Lys Pro Tyr Val Ala Thr 
145                 150                 155                 160 


Leu Ser Leu His Ser Leu Phe Glu Leu Arg Ser Cys Leu Ile Asn Gly 
                165                 170                 175     


Thr Val Leu Leu Asp Met His Ala Asn Ser Ile Glu Glu Ile Ser Asp 
            180                 185                 190         


Leu Ile Leu Asp Gln Gln Glu Leu Ser Ser Asp Leu Asn Asp Ser Met 
        195                 200                 205             


Arg Val Lys Val Arg Glu Ala Leu Leu Lys Lys His His His Gln Asn 
    210                 215                 220                 


Glu Lys Lys Arg Asn Asn Leu Ile Pro Ile Val Arg Ser Phe Ala Glu 
225                 230                 235                 240 


Val Gly Lys Lys Gln Ser Asp Pro His Leu Met Asp Lys His Gly Gln 
                245                 250                 255     


Thr Val Ser Pro Gln Ser Val Pro Thr Thr Asn Leu Glu Val Lys Asn 
            260                 265                 270         


Gly Val Asn Cys Glu His Ser Pro Val Asp Leu Ser Lys Val Asp Leu 
        275                 280                 285             


His Phe Met Lys Lys Ile Pro Thr Gly Ala Glu Ala Ser Asn Val Leu 
    290                 295                 300                 


Val Gly Glu Val Asp Ile Leu Asp Arg Pro Ile Val Ala Phe Val Arg 
305                 310                 315                 320 


Leu Ser Pro Ala Val Leu Leu Ser Gly Leu Thr Glu Val Pro Ile Pro 
                325                 330                 335     


Thr Arg Phe Leu Phe Ile Leu Leu Gly Pro Val Gly Lys Gly Gln Gln 
            340                 345                 350         


Tyr His Glu Ile Gly Arg Ser Met Ala Thr Ile Met Thr Asp Glu Ile 
        355                 360                 365             


Phe His Asp Val Ala Tyr Lys Ala Lys Glu Arg Asp Asp Leu Leu Ala 
    370                 375                 380                 


Gly Ile Asp Glu Phe Leu Asp Gln Val Thr Val Leu Pro Pro Gly Glu 
385                 390                 395                 400 


Trp Asp Pro Ser Ile Arg Ile Glu Pro Pro Lys Asn Val Pro Ser Gln 
                405                 410                 415     


Glu Lys Arg Lys Met Pro Gly Val Pro Asn Gly Asn Val Cys His Ile 
            420                 425                 430         


Glu Gln Glu Pro His Gly Gly His Ser Gly Pro Glu Leu Gln Arg Thr 
        435                 440                 445             


Gly Arg Leu Phe Gly Gly Leu Val Leu Asp Ile Lys Arg Lys Ala Pro 
    450                 455                 460                 


Trp Tyr Trp Ser Asp Tyr Arg Asp Ala Leu Ser Leu Gln Cys Leu Ala 
465                 470                 475                 480 


Ser Phe Leu Phe Leu Tyr Cys Ala Cys Met Ser Pro Val Ile Thr Phe 
                485                 490                 495     


Gly Gly Leu Leu Gly Glu Ala Thr Glu Gly Arg Ile Ser Ala Ile Glu 
            500                 505                 510         


Ser Leu Phe Gly Ala Ser Met Thr Gly Ile Ala Tyr Ser Leu Phe Ala 
        515                 520                 525             


Gly Gln Ala Leu Thr Ile Leu Gly Ser Thr Gly Pro Val Leu Val Phe 
    530                 535                 540                 


Glu Lys Ile Leu Phe Lys Phe Cys Lys Asp Tyr Ala Leu Ser Tyr Leu 
545                 550                 555                 560 


Ser Leu Arg Ala Cys Ile Gly Leu Trp Thr Ala Phe Leu Cys Ile Val 
                565                 570                 575     


Leu Val Ala Thr Asp Ala Ser Ser Leu Val Cys Tyr Ile Thr Arg Phe 
            580                 585                 590         


Thr Glu Glu Ala Phe Ala Ser Leu Ile Cys Ile Ile Phe Ile Tyr Glu 
        595                 600                 605             


Ala Ile Glu Lys Leu Ile His Leu Ala Glu Thr Tyr Pro Ile His Met 
    610                 615                 620                 


His Ser Gln Leu Asp His Leu Ser Leu Tyr Tyr Cys Arg Cys Thr Leu 
625                 630                 635                 640 


Pro Glu Asn Pro Asn Asn His Thr Leu Gln Tyr Trp Lys Asp His Asn 
                645                 650                 655     


Ile Val Thr Ala Glu Val His Trp Ala Asn Leu Thr Val Ser Glu Cys 
            660                 665                 670         


Gln Glu Met His Gly Glu Phe Met Gly Ser Ala Cys Gly His His Gly 
        675                 680                 685             


Pro Tyr Thr Pro Asp Val Leu Phe Trp Ser Cys Ile Leu Phe Phe Thr 
    690                 695                 700                 


Thr Phe Ile Leu Ser Ser Thr Leu Lys Thr Phe Lys Thr Ser Arg Tyr 
705                 710                 715                 720 


Phe Pro Thr Arg Val Arg Ser Met Val Ser Asp Phe Ala Val Phe Leu 
                725                 730                 735     


Thr Ile Phe Thr Met Val Ile Ile Asp Phe Leu Ile Gly Val Pro Ser 
            740                 745                 750         


Pro Lys Leu Gln Val Pro Ser Val Phe Lys Pro Thr Arg Asp Asp Arg 
        755                 760                 765             


Gly Trp Ile Ile Asn Pro Ile Gly Pro Asn Pro Trp Trp Thr Val Ile 
    770                 775                 780                 


Ala Ala Ile Ile Pro Ala Leu Leu Cys Thr Ile Leu Ile Phe Met Asp 
785                 790                 795                 800 


Gln Gln Ile Thr Ala Val Ile Ile Asn Arg Lys Glu His Lys Leu Lys 
                805                 810                 815     


Lys Gly Cys Gly Tyr His Leu Asp Leu Leu Met Val Ala Ile Met Leu 
            820                 825                 830         


Gly Val Cys Ser Ile Met Gly Leu Pro Trp Phe Val Ala Ala Thr Val 
        835                 840                 845             


Leu Ser Ile Thr His Val Asn Ser Leu Lys Leu Glu Ser Glu Cys Ser 
    850                 855                 860                 


Ala Pro Gly Glu Gln Pro Lys Phe Leu Gly Ile Arg Glu Gln Arg Val 
865                 870                 875                 880 


Thr Gly Leu Met Ile Phe Val Leu Met Gly Cys Ser Val Phe Met Thr 
                885                 890                 895     


Ala Ile Leu Lys Phe Ile Pro Met Pro Val Leu Tyr Gly Val Phe Leu 
            900                 905                 910         


Tyr Met Gly Val Ser Ser Leu Gln Gly Ile Gln Phe Phe Asp Arg Leu 
        915                 920                 925             


Lys Leu Phe Gly Met Pro Ala Lys His Gln Pro Asp Phe Ile Tyr Leu 
    930                 935                 940                 


Arg His Val Pro Leu Arg Lys Val His Leu Phe Thr Leu Ile Gln Leu 
945                 950                 955                 960 


Thr Cys Leu Val Leu Leu Trp Val Ile Lys Ala Ser Pro Ala Ala Ile 
                965                 970                 975     


Val Phe Pro Met Met Val Leu Ala Leu Val Phe Val Arg Lys Val Met 
            980                 985                 990         


Asp Leu Cys Phe Ser Lys Arg Glu  Leu Ser Trp Leu Asp  Asp Leu Met 
        995                 1000                 1005             


Pro Glu  Ser Lys Lys Lys Lys  Leu Asp Asp Ala Lys  Lys Lys Ala 
    1010                 1015                 1020             


Lys Glu  Glu Glu Glu Ala Glu  Lys Met Leu Glu Ile  Gly Gly Asp 
    1025                 1030                 1035             


Lys Phe  Pro Leu Glu Ser Arg  Lys Leu Leu Ser Ser  Pro Gly Lys 
    1040                 1045                 1050             


Asn Ile  Ser Cys Arg Cys Asp  Pro Ser Glu Ile Asn  Ile Ser Asp 
    1055                 1060                 1065             


Glu Met  Pro Lys Thr Thr Val  Trp Lys Ala Leu Ser  Met Asn Ser 
    1070                 1075                 1080             


Gly Asn  Ala Lys Glu Lys Ser  Leu Phe Asn 
    1085                 1090             


<210>  819
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  819

Met Asp Val Thr Ser Gln Ala Arg Gly Val Gly Leu Glu Met Tyr Pro 
1               5                   10                  15      


Gly Thr Ala Gln Pro Ala Ala Pro Asn Thr Thr Ser Pro Glu Leu Asn 
            20                  25                  30          


Leu Ser His Pro Leu Leu Gly Thr Ala Leu Ala Asn Gly Thr Gly Glu 
        35                  40                  45              


Leu Ser Glu His Gln Gln Tyr Val Ile Gly Leu Phe Leu Ser Cys Leu 
    50                  55                  60                  


Tyr Thr Ile Phe Leu Phe Pro Ile Gly Phe Val Gly Asn Ile Leu Ile 
65                  70                  75                  80  


Leu Val Val Asn Ile Ser Phe Arg Glu Lys Met Thr Ile Pro Asp Leu 
                85                  90                  95      


Tyr Phe Ile Asn Leu Ala Val Ala Asp Leu Ile Leu Val Ala Asp Ser 
            100                 105                 110         


Leu Ile Glu Val Phe Asn Leu His Glu Arg Tyr Tyr Asp Ile Ala Val 
        115                 120                 125             


Leu Cys Thr Phe Met Ser Leu Phe Leu Gln Val Asn Met Tyr Ser Ser 
    130                 135                 140                 


Val Phe Phe Leu Thr Trp Met Ser Phe Asp Arg Tyr Ile Ala Leu Ala 
145                 150                 155                 160 


Arg Ala Met Arg Cys Ser Leu Phe Arg Thr Lys His His Ala Arg Leu 
                165                 170                 175     


Ser Cys Gly Leu Ile Trp Met Ala Ser Val Ser Ala Thr Leu Val Pro 
            180                 185                 190         


Phe Thr Ala Val His Leu Gln His Thr Asp Glu Ala Cys Phe Cys Phe 
        195                 200                 205             


Ala Asp Val Arg Glu Val Gln Trp Leu Glu Val Thr Leu Gly Phe Ile 
    210                 215                 220                 


Val Pro Phe Ala Ile Ile Gly Leu Cys Tyr Ser Leu Ile Val Arg Val 
225                 230                 235                 240 


Leu Val Arg Ala His Arg His Arg Gly Leu Arg Pro Arg Arg Gln Lys 
                245                 250                 255     


Ala Leu Arg Met Ile Leu Ala Val Val Leu Val Phe Phe Val Cys Trp 
            260                 265                 270         


Leu Pro Glu Asn Val Phe Ile Ser Val His Leu Leu Gln Arg Thr Gln 
        275                 280                 285             


Pro Gly Ala Ala Pro Cys Lys Gln Ser Phe Arg His Ala His Pro Leu 
    290                 295                 300                 


Thr Gly His Ile Val Asn Leu Ala Ala Phe Ser Asn Ser Cys Leu Asn 
305                 310                 315                 320 


Pro Leu Ile Tyr Ser Phe Leu Gly Glu Thr Phe Arg Asp Lys Leu Arg 
                325                 330                 335     


Leu Tyr Ile Glu Gln Lys Thr Asn Leu Pro Ala Leu Asn Arg Phe Cys 
            340                 345                 350         


His Ala Ala Leu Lys Ala Val Ile Pro Asp Ser Thr Glu Gln Ser Asp 
        355                 360                 365             


Val Arg Phe Ser Ser Ala Val 
    370                 375 


<210>  820
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  820

Met Asn Tyr Glu Gly Ala Arg Ser Glu Arg Glu Asn His Ala Ala Asp 
1               5                   10                  15      


Asp Ser Glu Gly Gly Ala Leu Asp Met Cys Cys Ser Glu Arg Leu Pro 
            20                  25                  30          


Gly Leu Pro Gln Pro Ile Val Met Glu Ala Leu Asp Glu Ala Glu Gly 
        35                  40                  45              


Leu Gln Asp Ser Gln Arg Glu Met Pro Pro Pro Pro Pro Pro Ser Pro 
    50                  55                  60                  


Pro Ser Asp Pro Ala Gln Lys Pro Pro Pro Arg Gly Ala Gly Ser His 
65                  70                  75                  80  


Ser Leu Thr Val Arg Ser Ser Leu Cys Leu Phe Ala Ala Ser Gln Phe 
                85                  90                  95      


Leu Leu Glu Pro Thr Ala Trp Leu Asp Ser Gly Thr Trp Gly Val Pro 
            100                 105                 110         


Ser Leu Leu Leu Val Phe Leu Ser Val Gly Leu Val Leu Val Thr Thr 
        115                 120                 125             


Leu Val Trp His Leu Leu Arg Thr Pro Pro Glu Pro Pro Thr Pro Leu 
    130                 135                 140                 


Pro Pro Glu Asp Arg Arg Gln Ser Val Ser Arg Gln Pro Ser Phe Thr 
145                 150                 155                 160 


Tyr Ser Glu Trp Met Glu Glu Lys Ile Glu Asp Asp Phe Leu Asp Leu 
                165                 170                 175     


Asp Pro Val Pro Glu Thr Pro Val Phe Asp Cys Val Met Asp Ile Lys 
            180                 185                 190         


Pro Glu Ala Asp Pro Thr Ser Leu Thr Val Lys Ser Met Gly Leu Gln 
        195                 200                 205             


Glu Arg Arg Gly Ser Asn Val Ser Leu Thr Leu Asp Met Cys Thr Pro 
    210                 215                 220                 


Gly Cys Asn Glu Glu Gly Phe Gly Tyr Leu Met Ser Pro Arg Glu Glu 
225                 230                 235                 240 


Ser Ala Arg Glu Tyr Leu Leu Ser Ala Ser Arg Val Leu Gln Ala Glu 
                245                 250                 255     


Glu Leu His Glu Lys Ala Leu Asp Pro Phe Leu Leu Gln Ala Glu Phe 
            260                 265                 270         


Phe Glu Ile Pro Met Asn Phe Val Asp Pro Lys Glu Tyr Asp Ile Pro 
        275                 280                 285             


Gly Leu Val Arg Lys Asn Arg Tyr Lys Thr Ile Leu Pro Asn Pro His 
    290                 295                 300                 


Ser Arg Val Cys Leu Thr Ser Pro Asp Pro Asp Asp Pro Leu Ser Ser 
305                 310                 315                 320 


Tyr Ile Asn Ala Asn Tyr Ile Arg Gly Tyr Gly Gly Glu Glu Lys Val 
                325                 330                 335     


Tyr Ile Ala Thr Gln Gly Pro Ile Val Ser Thr Val Ala Asp Phe Trp 
            340                 345                 350         


Arg Met Val Trp Gln Glu His Thr Pro Ile Ile Val Met Ile Thr Asn 
        355                 360                 365             


Ile Glu Glu Met Asn Glu Lys Cys Thr Glu Tyr Trp Pro Glu Glu Gln 
    370                 375                 380                 


Val Ala Tyr Asp Gly Val Glu Ile Thr Val Gln Lys Val Ile His Thr 
385                 390                 395                 400 


Glu Asp Tyr Arg Leu Arg Leu Ile Ser Leu Lys Ser Gly Thr Glu Glu 
                405                 410                 415     


Arg Gly Leu Lys His Tyr Trp Phe Thr Ser Trp Pro Asp Gln Lys Thr 
            420                 425                 430         


Pro Asp Arg Ala Pro Pro Leu Leu His Leu Val Arg Glu Val Glu Glu 
        435                 440                 445             


Ala Ala Gln Gln Glu Gly Pro His Cys Ala Pro Ile Ile Val His Cys 
    450                 455                 460                 


Ser Ala Gly Ile Gly Arg Thr Gly Cys Phe Ile Ala Thr Ser Ile Cys 
465                 470                 475                 480 


Cys Gln Gln Leu Arg Gln Glu Gly Val Val Asp Ile Leu Lys Thr Thr 
                485                 490                 495     


Cys Gln Leu Arg Gln Asp Arg Gly Gly Met Ile Gln Thr Cys Glu Gln 
            500                 505                 510         


Tyr Gln Phe Val His His Val Met Ser Leu Tyr Glu Lys Gln Leu Ser 
        515                 520                 525             


His Gln Ser Pro Glu 
    530             


<210>  821
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  821

Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu 
            20                  25                  30          


Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala Ala Gly 
        35                  40                  45              


Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro Val Gly 
    50                  55                  60                  


Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu Ile Tyr 
65                  70                  75                  80  


Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu 
                85                  90                  95      


Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn Ile Thr 
            100                 105                 110         


Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 
        115                 120                 125             


Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val 
    130                 135                 140                 


Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala 
145                 150                 155                 160 


Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser 
                165                 170                 175     


Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser 
            180                 185                 190         


Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser 
        195                 200                 205             


Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser 
    210                 215                 220                 


Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu 
225                 230                 235                 240 


Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu 
                245                 250                 255     


Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr 
            260                 265                 270         


Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu 
        275                 280                 285             


Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu 
    290                 295                 300                 


Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val 
305                 310                 315                 320 


Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp 
                325                 330                 335     


Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His 
            340                 345                 350         


Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn 
        355                 360                 365             


Glu Arg Asn Ile Tyr Ile Val Val Gly Val Val Cys Thr Leu Leu Val 
    370                 375                 380                 


Ala Leu Leu Met Ala Ala Leu Tyr Leu Val Arg Ile Arg Gln Lys Lys 
385                 390                 395                 400 


Ala Gln Gly Ser Thr Ser Ser Thr Arg Leu His Glu Pro Glu Lys Asn 
                405                 410                 415     


Ala Arg Glu Ile Thr Gln Asp Thr Asn Asp Ile Thr Tyr Ala Asp Leu 
            420                 425                 430         


Asn Leu Pro Lys Gly Lys Lys Pro Ala Pro Gln Ala Ala Glu Pro Asn 
        435                 440                 445             


Asn His Thr Glu Tyr Ala Ser Ile Gln Thr Ser Pro Gln Pro Ala Ser 
    450                 455                 460                 


Glu Asp Thr Leu Thr Tyr Ala Asp Leu Asp Met Val His Leu Asn Arg 
465                 470                 475                 480 


Thr Pro Lys Gln Pro Ala Pro Lys Pro Glu Pro Ser Phe Ser Glu Tyr 
                485                 490                 495     


Ala Ser Val Gln Val Pro Arg Lys 
            500                 


<210>  822
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  822

Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu 
            20                  25                  30          


Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala Ala Gly 
        35                  40                  45              


Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro Val Gly 
    50                  55                  60                  


Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu Ile Tyr 
65                  70                  75                  80  


Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu 
                85                  90                  95      


Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn Ile Thr 
            100                 105                 110         


Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 
        115                 120                 125             


Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val 
    130                 135                 140                 


Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala 
145                 150                 155                 160 


Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser 
                165                 170                 175     


Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser 
            180                 185                 190         


Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser 
        195                 200                 205             


Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser 
    210                 215                 220                 


Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu 
225                 230                 235                 240 


Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu 
                245                 250                 255     


Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr 
            260                 265                 270         


Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu 
        275                 280                 285             


Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu 
    290                 295                 300                 


Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val 
305                 310                 315                 320 


Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp 
                325                 330                 335     


Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His 
            340                 345                 350         


Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn 
        355                 360                 365             


Glu Arg Asn Ile Tyr Ile Val Val Gly Val Val Cys Thr Leu Leu Val 
    370                 375                 380                 


Ala Leu Leu Met Ala Ala Leu Tyr Leu Val Arg Ile Arg Gln Lys Lys 
385                 390                 395                 400 


Ala Gln Gly Ser Thr Ser Ser Thr Arg Leu His Glu Pro Glu Lys Asn 
                405                 410                 415     


Ala Arg Glu Ile Thr Gln Asp Thr Asn Asp Ile Thr Tyr Ala Asp Leu 
            420                 425                 430         


Asn Leu Pro Lys Gly Lys Lys Pro Ala Pro Gln Ala Ala Glu Pro Asn 
        435                 440                 445             


Asn His Thr Glu Tyr Ala Ser Ile Gln Thr Ser Pro Gln Pro Ala Ser 
    450                 455                 460                 


Glu Asp Thr Leu Thr Tyr Ala Asp Leu Asp Met Val His Leu Asn Arg 
465                 470                 475                 480 


Thr Pro Lys Gln Pro Ala Pro Lys Pro Glu Pro Ser Phe Ser Glu Tyr 
                485                 490                 495     


Ala Ser Val Gln Val Pro Arg Lys 
            500                 


<210>  823
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  823

Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu Lys Glu Leu Arg 
1               5                   10                  15      


Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu Leu Phe Ala Thr 
            20                  25                  30          


Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln Arg Ala Gln Leu Glu 
        35                  40                  45              


Arg Ser Leu Arg Asp Val Val Glu Lys Thr Ile Gln Lys Tyr Gly Thr 
    50                  55                  60                  


Asn Pro Glu Glu Thr Ala Ala Glu Glu Ser Trp Asp Tyr Val Gln Phe 
65                  70                  75                  80  


Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln Asp Trp Phe Gln Val 
                85                  90                  95      


Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His Arg Val Pro Cys Ser 
            100                 105                 110         


Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser Thr Ile Leu Asp Lys Val 
        115                 120                 125             


Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu Ala Arg Ser Arg His 
    130                 135                 140                 


Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser His Ile Tyr Arg Glu 
145                 150                 155                 160 


Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His Asn Asn Leu Ile Ser 
                165                 170                 175     


Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu Leu Gly Phe Met 
            180                 185                 190         


Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His Val Tyr Asn Arg 
        195                 200                 205             


Leu Ala Arg Tyr Arg 
    210             


<210>  824
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  824

Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
            20                  25                  30          


Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro 
        35                  40                  45              


Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met 
    50                  55                  60                  


Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
65                  70                  75                  80  


Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu 
                85                  90                  95      


Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu 
            100                 105                 110         


Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp 
        115                 120                 125             


Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys 
    130                 135                 140                 


Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser 
145                 150                 155                 160 


Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu 
                165                 170                 175     


Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val 
            180                 185                 190         


Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys 
        195                 200                 205             


Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu 
    210                 215                 


<210>  825
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  825

Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly 
            20                  25                  30          


Val Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr 
        35                  40                  45              


Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu 
    50                  55                  60                  


Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr 
65                  70                  75                  80  


Cys Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val 
                85                  90                  95      


Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met 
            100                 105                 110         


Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys 
        115                 120                 125             


Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys 
    130                 135                 140                 


Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met 
145                 150                 155                 160 


Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly 
                165                 170                 175     


Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val 
            180                 185                 190         


Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala 
        195                 200                 205             


Ala Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala 
    210                 215                 220                 


Cys Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met 
225                 230                 235             


<210>  826
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  826

Met Arg Leu Ala Val Leu Phe Ser Gly Ala Leu Leu Gly Leu Leu Ala 
1               5                   10                  15      


Glu Ser Thr Gly Thr Thr Ser His Arg Thr Thr Lys Ser His Lys Thr 
            20                  25                  30          


Thr Thr His Arg Thr Thr Thr Thr Gly Thr Thr Ser His Gly Pro Thr 
        35                  40                  45              


Thr Ala Thr His Asn Pro Thr Thr Thr Ser His Gly Asn Val Thr Val 
    50                  55                  60                  


His Pro Thr Ser Asn Ser Thr Ala Thr Ser Gln Gly Pro Ser Thr Ala 
65                  70                  75                  80  


Thr His Ser Pro Ala Thr Thr Ser His Gly Asn Ala Thr Val His Pro 
                85                  90                  95      


Thr Ser Asn Ser Thr Ala Thr Ser Pro Gly Phe Thr Ser Ser Ala His 
            100                 105                 110         


Pro Glu Pro Pro Pro Pro Ser Pro Ser Pro Ser Pro Thr Ser Lys Glu 
        115                 120                 125             


Thr Ile Gly Asp Tyr Thr Trp Thr Asn Gly Ser Gln Pro Cys Val His 
    130                 135                 140                 


Leu Gln Ala Gln Ile Gln Ile Arg Val Met Tyr Thr Thr Gln Gly Gly 
145                 150                 155                 160 


Gly Glu Ala Trp Gly Ile Ser Val Leu Asn Pro Asn Lys Thr Lys Val 
                165                 170                 175     


Gln Gly Ser Cys Glu Gly Ala His Pro His Leu Leu Leu Ser Phe Pro 
            180                 185                 190         


Tyr Gly His Leu Ser Phe Gly Phe Met Gln Asp Leu Gln Gln Lys Val 
        195                 200                 205             


Val Tyr Leu Ser Tyr Met Ala Val Glu Tyr Asn Val Ser Phe Pro His 
    210                 215                 220                 


Ala Ala Gln Trp Thr Phe Ser Ala Gln Asn Ala Ser Leu Arg Asp Leu 
225                 230                 235                 240 


Gln Ala Pro Leu Gly Gln Ser Phe Ser Cys Ser Asn Ser Ser Ile Ile 
                245                 250                 255     


Leu Ser Pro Ala Val His Leu Asp Leu Leu Ser Leu Arg Leu Gln Ala 
            260                 265                 270         


Ala Gln Leu Pro His Thr Gly Val Phe Gly Gln Ser Phe Ser Cys Pro 
        275                 280                 285             


Ser Asp Arg Ser Ile Leu Leu Pro Leu Ile Ile Gly Leu Ile Leu Leu 
    290                 295                 300                 


Gly Leu Leu Ala Leu Val Leu Ile Ala Phe Cys Ile Ile Arg Arg Arg 
305                 310                 315                 320 


Pro Ser Ala Tyr Gln Ala Leu 
                325         


<210>  827
<211>  863
<212>  PRT
<213>  Homo sapiens

<400>  827

Met Ala Arg Arg Ser Ser Phe Gln Ser Cys Gln Ile Ile Ser Leu Phe 
1               5                   10                  15      


Thr Phe Ala Val Gly Val Asn Ile Cys Leu Gly Phe Thr Ala His Arg 
            20                  25                  30          


Ile Lys Arg Ala Glu Gly Trp Glu Glu Gly Pro Pro Thr Val Leu Ser 
        35                  40                  45              


Asp Ser Pro Trp Thr Asn Ile Ser Gly Ser Cys Lys Gly Arg Cys Phe 
    50                  55                  60                  


Glu Leu Gln Glu Ala Gly Pro Pro Asp Cys Arg Cys Asp Asn Leu Cys 
65                  70                  75                  80  


Lys Ser Tyr Thr Ser Cys Cys His Asp Phe Asp Glu Leu Cys Leu Lys 
                85                  90                  95      


Thr Ala Arg Gly Trp Glu Cys Thr Lys Asp Arg Cys Gly Glu Val Arg 
            100                 105                 110         


Asn Glu Glu Asn Ala Cys His Cys Ser Glu Asp Cys Leu Ala Arg Gly 
        115                 120                 125             


Asp Cys Cys Thr Asn Tyr Gln Val Val Cys Lys Gly Glu Ser His Trp 
    130                 135                 140                 


Val Asp Asp Asp Cys Glu Glu Ile Lys Ala Ala Glu Cys Pro Ala Gly 
145                 150                 155                 160 


Phe Val Arg Pro Pro Leu Ile Ile Phe Ser Val Asp Gly Phe Arg Ala 
                165                 170                 175     


Ser Tyr Met Lys Lys Gly Ser Lys Val Met Pro Asn Ile Glu Lys Leu 
            180                 185                 190         


Arg Ser Cys Gly Thr His Ser Pro Tyr Met Arg Pro Val Tyr Pro Thr 
        195                 200                 205             


Lys Thr Phe Pro Asn Leu Tyr Thr Leu Ala Thr Gly Leu Tyr Pro Glu 
    210                 215                 220                 


Ser His Gly Ile Val Gly Asn Ser Met Tyr Asp Pro Val Phe Asp Ala 
225                 230                 235                 240 


Thr Phe His Leu Arg Gly Arg Glu Lys Phe Asn His Arg Trp Trp Gly 
                245                 250                 255     


Gly Gln Pro Leu Trp Ile Thr Ala Thr Lys Gln Gly Val Lys Ala Gly 
            260                 265                 270         


Thr Phe Phe Trp Ser Val Val Ile Pro His Glu Arg Arg Ile Leu Thr 
        275                 280                 285             


Ile Leu Gln Trp Leu Thr Leu Pro Asp His Glu Arg Pro Ser Val Tyr 
    290                 295                 300                 


Ala Phe Tyr Ser Glu Gln Pro Asp Phe Ser Gly His Lys Tyr Gly Pro 
305                 310                 315                 320 


Phe Gly Pro Glu Met Thr Asn Pro Leu Arg Glu Ile Asp Lys Ile Val 
                325                 330                 335     


Gly Gln Leu Met Asp Gly Leu Lys Gln Leu Lys Leu His Arg Cys Val 
            340                 345                 350         


Asn Val Ile Phe Val Gly Asp His Gly Met Glu Asp Val Thr Cys Asp 
        355                 360                 365             


Arg Thr Glu Phe Leu Ser Asn Tyr Leu Thr Asn Val Asp Asp Ile Thr 
    370                 375                 380                 


Leu Val Pro Gly Thr Leu Gly Arg Ile Arg Ser Lys Phe Ser Asn Asn 
385                 390                 395                 400 


Ala Lys Tyr Asp Pro Lys Ala Ile Ile Ala Asn Leu Thr Cys Lys Lys 
                405                 410                 415     


Pro Asp Gln His Phe Lys Pro Tyr Leu Lys Gln His Leu Pro Lys Arg 
            420                 425                 430         


Leu His Tyr Ala Asn Asn Arg Arg Ile Glu Asp Ile His Leu Leu Val 
        435                 440                 445             


Glu Arg Arg Trp His Val Ala Arg Lys Pro Leu Asp Val Tyr Lys Lys 
    450                 455                 460                 


Pro Ser Gly Lys Cys Phe Phe Gln Gly Asp His Gly Phe Asp Asn Lys 
465                 470                 475                 480 


Val Asn Ser Met Gln Thr Val Phe Val Gly Tyr Gly Ser Thr Phe Lys 
                485                 490                 495     


Tyr Lys Thr Lys Val Pro Pro Phe Glu Asn Ile Glu Leu Tyr Asn Val 
            500                 505                 510         


Met Cys Asp Leu Leu Gly Leu Lys Pro Ala Pro Asn Asn Gly Thr His 
        515                 520                 525             


Gly Ser Leu Asn His Leu Leu Arg Thr Asn Thr Phe Arg Pro Thr Met 
    530                 535                 540                 


Pro Glu Glu Val Thr Arg Pro Asn Tyr Pro Gly Ile Met Tyr Leu Gln 
545                 550                 555                 560 


Ser Asp Phe Asp Leu Gly Cys Thr Cys Asp Asp Lys Val Glu Pro Lys 
                565                 570                 575     


Asn Lys Leu Asp Glu Leu Asn Lys Arg Leu His Thr Lys Gly Ser Thr 
            580                 585                 590         


Glu Glu Arg His Leu Leu Tyr Gly Arg Pro Ala Val Leu Tyr Arg Thr 
        595                 600                 605             


Arg Tyr Asp Ile Leu Tyr His Thr Asp Phe Glu Ser Gly Tyr Ser Glu 
    610                 615                 620                 


Ile Phe Leu Met Pro Leu Trp Thr Ser Tyr Thr Val Ser Lys Gln Ala 
625                 630                 635                 640 


Glu Val Ser Ser Val Pro Asp His Leu Thr Ser Cys Val Arg Pro Asp 
                645                 650                 655     


Val Arg Val Ser Pro Ser Phe Ser Gln Asn Cys Leu Ala Tyr Lys Asn 
            660                 665                 670         


Asp Lys Gln Met Ser Tyr Gly Phe Leu Phe Pro Pro Tyr Leu Ser Ser 
        675                 680                 685             


Ser Pro Glu Ala Lys Tyr Asp Ala Phe Leu Val Thr Asn Met Val Pro 
    690                 695                 700                 


Met Tyr Pro Ala Phe Lys Arg Val Trp Asn Tyr Phe Gln Arg Val Leu 
705                 710                 715                 720 


Val Lys Lys Tyr Ala Ser Glu Arg Asn Gly Val Asn Val Ile Ser Gly 
                725                 730                 735     


Pro Ile Phe Asp Tyr Asp Tyr Asp Gly Leu His Asp Thr Glu Asp Lys 
            740                 745                 750         


Ile Lys Gln Tyr Val Glu Gly Ser Ser Ile Pro Val Pro Thr His Tyr 
        755                 760                 765             


Tyr Ser Ile Ile Thr Ser Cys Leu Asp Phe Thr Gln Pro Ala Asp Lys 
    770                 775                 780                 


Cys Asp Gly Pro Leu Ser Val Ser Ser Phe Ile Leu Pro His Arg Pro 
785                 790                 795                 800 


Asp Asn Glu Glu Ser Cys Asn Ser Ser Glu Asp Glu Ser Lys Trp Val 
                805                 810                 815     


Glu Glu Leu Met Lys Met His Thr Ala Arg Val Arg Asp Ile Glu His 
            820                 825                 830         


Leu Thr Ser Leu Asp Phe Phe Arg Lys Thr Ser Arg Ser Tyr Pro Glu 
        835                 840                 845             


Ile Leu Thr Leu Lys Thr Tyr Leu His Thr Tyr Glu Ser Glu Ile 
    850                 855                 860             


<210>  828
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  828

Met Arg Arg Gly Ala Pro Gln Asp Gln Glu Leu Val Gly Pro Gly Pro 
1               5                   10                  15      


Pro Gly Arg Gly Ser Arg Gly Ala Pro Pro Pro Leu Gly Pro Val Val 
            20                  25                  30          


Pro Val Leu Val Phe Pro Pro Asp Leu Val Phe Arg Ala Asp Gln Arg 
        35                  40                  45              


Ser Gly Pro Arg Gln Leu Leu Thr Leu Tyr Asn Pro Thr Gly Thr Ala 
    50                  55                  60                  


Leu Arg Phe Arg Val Leu Cys Thr Ala Pro Ala Lys Tyr Thr Val Phe 
65                  70                  75                  80  


Asp Ala Glu Gly Tyr Val Lys Pro Gln Ser Cys Ile Asp Ile Val Ile 
                85                  90                  95      


Arg His Val Ala Pro Ile Pro Ser His Tyr Asp Val Gln Asp Arg Phe 
            100                 105                 110         


Arg Ile Glu Leu Ser Glu Glu Gly Ala Glu Gly Arg Val Val Gly Arg 
        115                 120                 125             


Lys Asp Ile Thr Ser Ile Leu Arg Ala Pro Ala Tyr Pro Leu Glu Leu 
    130                 135                 140                 


Gln Gly Gln Pro Asp Pro Ala Pro Arg Pro Gly Pro Pro Ala Gly Thr 
145                 150                 155                 160 


Pro Pro Pro Thr Ala Arg His Phe Gln Glu His Pro Arg Gln Gln Leu 
                165                 170                 175     


Ala Thr Ser Ser Phe Leu Leu Phe Leu Leu Thr Gly Ile Val Ser Val 
            180                 185                 190         


Ala Phe Leu Leu Leu Pro Leu Pro Asp Glu Leu Gly Ser Gln Leu Pro 
        195                 200                 205             


Gln Val Leu His Val Ser Leu Gly Gln Lys Leu Val Ala Ala Tyr Val 
    210                 215                 220                 


Leu Gly Leu Leu Thr Met Val Phe Leu Arg Thr 
225                 230                 235 


<210>  829
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  829

Met Arg Arg Gly Ala Pro Gln Asp Gln Glu Leu Val Gly Pro Gly Pro 
1               5                   10                  15      


Pro Gly Arg Gly Ser Arg Gly Ala Pro Pro Pro Leu Gly Pro Val Val 
            20                  25                  30          


Pro Val Leu Val Phe Pro Pro Asp Leu Val Phe Arg Ala Asp Gln Arg 
        35                  40                  45              


Ser Gly Pro Arg Gln Leu Leu Thr Leu Tyr Asn Pro Thr Gly Thr Ala 
    50                  55                  60                  


Leu Arg Phe Arg Val Leu Cys Thr Ala Pro Ala Lys Tyr Thr Val Phe 
65                  70                  75                  80  


Asp Ala Glu Gly Tyr Val Lys Pro Gln Ser Cys Ile Asp Ile Val Ile 
                85                  90                  95      


Arg His Val Ala Pro Ile Pro Ser His Tyr Asp Val Gln Asp Arg Phe 
            100                 105                 110         


Arg Ile Glu Leu Ser Glu Glu Gly Ala Glu Gly Arg Val Val Gly Arg 
        115                 120                 125             


Lys Asp Ile Thr Ser Ile Leu Arg Ala Pro Ala Tyr Pro Leu Glu Leu 
    130                 135                 140                 


Gln Gly Gln Pro Asp Pro Ala Pro Arg Pro Gly Pro Pro Ala Gly Thr 
145                 150                 155                 160 


Pro Pro Pro Thr Ala Arg His Phe Gln Glu His Pro Arg Gln Gln Leu 
                165                 170                 175     


Ala Thr Ser Ser Phe Leu Leu Phe Leu Leu Thr Gly Ile Val Ser Val 
            180                 185                 190         


Ala Phe Leu Leu Leu Pro Leu Pro Asp Glu Leu Gly Ser Gln Leu Pro 
        195                 200                 205             


Gln Val Leu His Val Ser Leu Gly Gln Lys Leu Val Ala Ala Tyr Val 
    210                 215                 220                 


Leu Gly Leu Leu Thr Met Val Phe Leu Arg Thr 
225                 230                 235 


<210>  830
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  830

Met Arg Arg Gly Ala Pro Gln Asp Gln Glu Leu Val Gly Pro Gly Pro 
1               5                   10                  15      


Pro Gly Arg Gly Ser Arg Gly Ala Pro Pro Pro Leu Gly Pro Val Val 
            20                  25                  30          


Pro Val Leu Val Phe Pro Pro Asp Leu Val Phe Arg Ala Asp Gln Arg 
        35                  40                  45              


Ser Gly Pro Arg Gln Leu Leu Thr Leu Tyr Asn Pro Thr Gly Thr Ala 
    50                  55                  60                  


Leu Arg Phe Arg Val Leu Cys Thr Ala Pro Ala Lys Tyr Thr Val Phe 
65                  70                  75                  80  


Asp Ala Glu Gly Tyr Val Lys Pro Gln Ser Cys Ile Asp Ile His Tyr 
                85                  90                  95      


Asp Val Gln Asp Arg Phe Arg Ile Glu Leu Ser Glu Glu Gly Ala Glu 
            100                 105                 110         


Gly Arg Val Val Gly Arg Lys Asp Ile Thr Ser Ile Leu Arg Ala Pro 
        115                 120                 125             


Ala Tyr Pro Leu Glu Leu Gln Gly Gln Pro Asp Pro Ala Pro Arg Pro 
    130                 135                 140                 


Gly Pro Pro Ala Gly Thr Pro Pro Pro Thr Ala Arg His Phe Gln Glu 
145                 150                 155                 160 


His Pro Arg Gln Gln Leu Ala Thr Ser Ser Phe Leu Leu Phe Leu Leu 
                165                 170                 175     


Thr Gly Ile Val Ser Val Ala Phe Leu Leu Leu Pro Leu Pro Asp Glu 
            180                 185                 190         


Leu Gly Ser Gln Leu Pro Gln Val Leu His Val Ser Leu Gly Gln Lys 
        195                 200                 205             


Leu Val Ala Ala Tyr Val Leu Gly Leu Leu Thr Met Val Phe Leu Arg 
    210                 215                 220                 


Thr 
225 


<210>  831
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  831

Met Asp Leu Arg Arg Val Lys Glu Tyr Phe Ser Trp Leu Tyr Tyr Gln 
1               5                   10                  15      


Tyr Gln Ile Ile Ser Cys Cys Ala Val Leu Glu Pro Trp Glu Arg Ser 
            20                  25                  30          


Met Phe Asn Thr Ile Leu Leu Thr Ile Ile Ala Met Val Val Tyr Thr 
        35                  40                  45              


Ala Tyr Val Phe Ile Pro Ile His Ile Arg Leu Ala Trp Glu Phe Phe 
    50                  55                  60                  


Ser Lys Ile Cys Gly Tyr His Ser Thr Ile Ser Asn 
65                  70                  75      


<210>  832
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  832

Met Val Lys Leu Gly Asn Asn Phe Ala Glu Lys Gly Thr Lys Gln Pro 
1               5                   10                  15      


Leu Leu Glu Asp Gly Phe Asp Thr Ile Pro Leu Met Thr Pro Leu Asp 
            20                  25                  30          


Val Asn Gln Leu Gln Phe Pro Pro Pro Asp Lys Val Val Val Lys Thr 
        35                  40                  45              


Lys Thr Glu Tyr Glu Pro Asp Arg Lys Lys Gly Lys Ala Arg Pro Pro 
    50                  55                  60                  


Gln Ile Ala Glu Phe Thr Val Ser Ile Thr Glu Gly Val Thr Glu Arg 
65                  70                  75                  80  


Phe Lys Val Ser Val Leu Val Leu Phe Ala Leu Ala Phe Leu Thr Cys 
                85                  90                  95      


Val Val Phe Leu Val Val Tyr Lys Val Tyr Lys Tyr Asp Arg Ala Cys 
            100                 105                 110         


Pro Asp Gly Phe Val Leu Lys Asn Thr Gln Cys Ile Pro Glu Gly Leu 
        115                 120                 125             


Glu Ser Tyr Tyr Ala Glu Gln Asp Ser Ser Ala Arg Glu Lys Phe Tyr 
    130                 135                 140                 


Thr Val Ile Asn His Tyr Asn Leu Ala Lys Gln Ser Ile Thr Arg Ser 
145                 150                 155                 160 


Val Ser Pro Trp Met Ser Val Leu Ser Glu Glu Lys Leu Ser Glu Gln 
                165                 170                 175     


Glu Thr Glu Ala Ala Glu Lys Ser Ala 
            180                 185 


<210>  833
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  833

Met Asp Cys Gly Pro Ser Leu Gly Leu Ala Ala Gly Ile Pro Leu Leu 
1               5                   10                  15      


Val Ala Thr Ala Leu Leu Val Ala Leu Leu Phe Thr Leu Ile His Arg 
            20                  25                  30          


Arg Arg Ser Ser Ile Glu Ala Met Glu Glu Ser Asp Arg Pro Cys Glu 
        35                  40                  45              


Ile Ser Glu Ile Asp Asp Asn Pro Lys Ile Ser Glu Asn Pro Arg Arg 
    50                  55                  60                  


Ser Pro Thr His Glu Lys Asn Thr Met Gly Ala Gln Glu Ala His Ile 
65                  70                  75                  80  


Tyr Val Lys Thr Val Ala Gly Ser Glu Glu Pro Val His Asp Arg Tyr 
                85                  90                  95      


Arg Pro Thr Ile Glu Met Glu Arg Arg Arg Gly Leu Trp Trp Leu Val 
            100                 105                 110         


Pro Arg Leu Ser Leu Glu 
        115             


<210>  834
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  834

Met Arg Met Thr Ser Ser Pro Val Thr Gly Gly Lys Glu Thr Asp Cys 
1               5                   10                  15      


Gly Pro Ser Leu Gly Leu Ala Ala Gly Ile Pro Leu Leu Val Ala Thr 
            20                  25                  30          


Ala Leu Leu Val Ala Leu Leu Phe Thr Leu Ile His Arg Arg Arg Ser 
        35                  40                  45              


Ser Ile Glu Ala Met Glu Glu Ser Asp Arg Pro Cys Glu Ile Ser Glu 
    50                  55                  60                  


Ile Asp Asp Asn Pro Lys Ile Ser Glu Asn Pro Arg Arg Ser Pro Thr 
65                  70                  75                  80  


His Glu Lys Asn Thr Met Gly Ala Gln Glu Ala His Ile Tyr Val Lys 
                85                  90                  95      


Thr Val Ala Gly Ser Glu Glu Pro Val His Asp Arg Tyr Arg Pro Thr 
            100                 105                 110         


Ile Glu Met Glu Arg Arg Arg Gly Leu Trp Trp Leu Val Pro Arg Leu 
        115                 120                 125             


Ser Leu Glu 
    130     


<210>  835
<211>  4493
<212>  PRT
<213>  Homo sapiens

<400>  835

Met Pro Arg Pro Gly Thr Met Ala Leu Cys Leu Leu Thr Leu Val Leu 
1               5                   10                  15      


Ser Leu Leu Pro Pro Gln Ala Ala Ala Glu Gln Asp Leu Ser Val Asn 
            20                  25                  30          


Arg Ala Val Trp Asp Gly Gly Gly Cys Ile Ser Gln Gly Asp Val Leu 
        35                  40                  45              


Asn Arg Gln Cys Gln Gln Leu Ser Gln His Val Arg Thr Gly Ser Ala 
    50                  55                  60                  


Ala Asn Thr Ala Thr Gly Thr Thr Ser Thr Asn Val Val Glu Pro Arg 
65                  70                  75                  80  


Met Tyr Leu Ser Cys Ser Thr Asn Pro Glu Met Thr Ser Ile Glu Ser 
                85                  90                  95      


Ser Val Thr Ser Asp Thr Pro Gly Val Ser Ser Thr Arg Met Thr Pro 
            100                 105                 110         


Thr Glu Ser Arg Thr Thr Ser Glu Ser Thr Ser Asp Ser Thr Thr Leu 
        115                 120                 125             


Phe Pro Ser Ser Thr Glu Asp Thr Ser Ser Pro Thr Thr Pro Glu Gly 
    130                 135                 140                 


Thr Asp Val Pro Met Ser Thr Pro Ser Glu Glu Ser Ile Ser Ser Thr 
145                 150                 155                 160 


Met Ala Phe Val Ser Thr Ala Pro Leu Pro Ser Phe Glu Ala Tyr Thr 
                165                 170                 175     


Ser Leu Thr Tyr Lys Val Asp Met Ser Thr Pro Leu Thr Thr Ser Thr 
            180                 185                 190         


Gln Ala Ser Ser Ser Pro Thr Thr Pro Glu Ser Thr Thr Ile Pro Lys 
        195                 200                 205             


Ser Thr Asn Ser Glu Gly Ser Thr Pro Leu Thr Ser Met Pro Ala Ser 
    210                 215                 220                 


Thr Met Lys Val Ala Ser Ser Glu Ala Ile Thr Leu Leu Thr Thr Pro 
225                 230                 235                 240 


Val Glu Ile Ser Thr Pro Val Thr Ile Ser Ala Gln Ala Ser Ser Ser 
                245                 250                 255     


Pro Thr Thr Ala Glu Gly Pro Ser Leu Ser Asn Ser Ala Pro Ser Gly 
            260                 265                 270         


Gly Ser Thr Pro Leu Thr Arg Met Pro Leu Ser Val Met Leu Val Val 
        275                 280                 285             


Ser Ser Glu Ala Ser Thr Leu Ser Thr Thr Pro Ala Ala Thr Asn Ile 
    290                 295                 300                 


Pro Val Ile Thr Ser Thr Glu Ala Ser Ser Ser Pro Thr Thr Ala Glu 
305                 310                 315                 320 


Gly Thr Ser Ile Pro Thr Ser Thr Tyr Thr Glu Gly Ser Thr Pro Leu 
                325                 330                 335     


Thr Ser Thr Pro Ala Ser Thr Met Pro Val Ala Thr Ser Glu Met Ser 
            340                 345                 350         


Thr Leu Ser Ile Thr Pro Val Asp Thr Ser Thr Leu Val Thr Thr Ser 
        355                 360                 365             


Thr Glu Pro Ser Ser Leu Pro Thr Thr Ala Glu Ala Thr Ser Met Leu 
    370                 375                 380                 


Thr Ser Thr Leu Ser Glu Gly Ser Thr Pro Leu Thr Asn Met Pro Val 
385                 390                 395                 400 


Ser Thr Ile Leu Val Ala Ser Ser Glu Ala Ser Thr Thr Ser Thr Ile 
                405                 410                 415     


Pro Val Asp Ser Lys Thr Phe Val Thr Thr Ala Ser Glu Ala Ser Ser 
            420                 425                 430         


Ser Pro Thr Thr Ala Glu Asp Thr Ser Ile Ala Thr Ser Thr Pro Ser 
        435                 440                 445             


Glu Gly Ser Thr Pro Leu Thr Ser Met Pro Val Ser Thr Thr Pro Val 
    450                 455                 460                 


Ala Ser Ser Glu Ala Ser Asn Leu Ser Thr Thr Pro Val Asp Ser Lys 
465                 470                 475                 480 


Thr Gln Val Thr Thr Ser Thr Glu Ala Ser Ser Ser Pro Pro Thr Ala 
                485                 490                 495     


Glu Val Asn Ser Met Pro Thr Ser Thr Pro Ser Glu Gly Ser Thr Pro 
            500                 505                 510         


Leu Thr Ser Met Ser Val Ser Thr Met Pro Val Ala Ser Ser Glu Ala 
        515                 520                 525             


Ser Thr Leu Ser Thr Thr Pro Val Asp Thr Ser Thr Pro Val Thr Thr 
    530                 535                 540                 


Ser Ser Glu Ala Ser Ser Ser Ser Thr Thr Pro Glu Gly Thr Ser Ile 
545                 550                 555                 560 


Pro Thr Ser Thr Pro Ser Glu Gly Ser Thr Pro Leu Thr Asn Met Pro 
                565                 570                 575     


Val Ser Thr Arg Leu Val Val Ser Ser Glu Ala Ser Thr Thr Ser Thr 
            580                 585                 590         


Thr Pro Ala Asp Ser Asn Thr Phe Val Thr Thr Ser Ser Glu Ala Ser 
        595                 600                 605             


Ser Ser Ser Thr Thr Ala Glu Gly Thr Ser Met Pro Thr Ser Thr Tyr 
    610                 615                 620                 


Ser Glu Arg Gly Thr Thr Ile Thr Ser Met Ser Val Ser Thr Thr Leu 
625                 630                 635                 640 


Val Ala Ser Ser Glu Ala Ser Thr Leu Ser Thr Thr Pro Val Asp Ser 
                645                 650                 655     


Asn Thr Pro Val Thr Thr Ser Thr Glu Ala Thr Ser Ser Ser Thr Thr 
            660                 665                 670         


Ala Glu Gly Thr Ser Met Pro Thr Ser Thr Tyr Thr Glu Gly Ser Thr 
        675                 680                 685             


Pro Leu Thr Ser Met Pro Val Asn Thr Thr Leu Val Ala Ser Ser Glu 
    690                 695                 700                 


Ala Ser Thr Leu Ser Thr Thr Pro Val Asp Thr Ser Thr Pro Val Thr 
705                 710                 715                 720 


Thr Ser Thr Glu Ala Ser Ser Ser Pro Thr Thr Ala Asp Gly Ala Ser 
                725                 730                 735     


Met Pro Thr Ser Thr Pro Ser Glu Gly Ser Thr Pro Leu Thr Ser Met 
            740                 745                 750         


Pro Val Ser Lys Thr Leu Leu Thr Ser Ser Glu Ala Ser Thr Leu Ser 
        755                 760                 765             


Thr Thr Pro Leu Asp Thr Ser Thr His Ile Thr Thr Ser Thr Glu Ala 
    770                 775                 780                 


Ser Cys Ser Pro Thr Thr Thr Glu Gly Thr Ser Met Pro Ile Ser Thr 
785                 790                 795                 800 


Pro Ser Glu Gly Ser Pro Leu Leu Thr Ser Ile Pro Val Ser Ile Thr 
                805                 810                 815     


Pro Val Thr Ser Pro Glu Ala Ser Thr Leu Ser Thr Thr Pro Val Asp 
            820                 825                 830         


Ser Asn Ser Pro Val Thr Thr Ser Thr Glu Val Ser Ser Ser Pro Thr 
        835                 840                 845             


Pro Ala Glu Gly Thr Ser Met Pro Thr Ser Thr Tyr Ser Glu Gly Arg 
    850                 855                 860                 


Thr Pro Leu Thr Ser Met Pro Val Ser Thr Thr Leu Val Ala Thr Ser 
865                 870                 875                 880 


Ala Ile Ser Thr Leu Ser Thr Thr Pro Val Asp Thr Ser Thr Pro Val 
                885                 890                 895     


Thr Asn Ser Thr Glu Ala Arg Ser Ser Pro Thr Thr Ser Glu Gly Thr 
            900                 905                 910         


Ser Met Pro Thr Ser Thr Pro Gly Glu Gly Ser Thr Pro Leu Thr Ser 
        915                 920                 925             


Met Pro Asp Ser Thr Thr Pro Val Val Ser Ser Glu Ala Arg Thr Leu 
    930                 935                 940                 


Ser Ala Thr Pro Val Asp Thr Ser Thr Pro Val Thr Thr Ser Thr Glu 
945                 950                 955                 960 


Ala Thr Ser Ser Pro Thr Thr Ala Glu Gly Thr Ser Ile Pro Thr Ser 
                965                 970                 975     


Thr Pro Ser Glu Gly Thr Thr Pro Leu Thr Ser Thr Pro Val Ser His 
            980                 985                 990         


Thr Leu Val Ala Asn Ser Glu Ala  Ser Thr Leu Ser Thr  Thr Pro Val 
        995                 1000                 1005             


Asp Ser  Asn Thr Pro Leu Thr  Thr Ser Thr Glu Ala  Ser Ser Pro 
    1010                 1015                 1020             


Pro Pro  Thr Ala Glu Gly Thr  Ser Met Pro Thr Ser  Thr Pro Ser 
    1025                 1030                 1035             


Glu Gly  Ser Thr Pro Leu Thr  Arg Met Pro Val Ser  Thr Thr Met 
    1040                 1045                 1050             


Val Ala  Ser Ser Glu Thr Ser  Thr Leu Ser Thr Thr  Pro Ala Asp 
    1055                 1060                 1065             


Thr Ser  Thr Pro Val Thr Thr  Tyr Ser Gln Ala Ser  Ser Ser Ser 
    1070                 1075                 1080             


Thr Thr  Ala Asp Gly Thr Ser  Met Pro Thr Ser Thr  Tyr Ser Glu 
    1085                 1090                 1095             


Gly Ser  Thr Pro Leu Thr Ser  Val Pro Val Ser Thr  Arg Leu Val 
    1100                 1105                 1110             


Val Ser  Ser Glu Ala Ser Thr  Leu Ser Thr Thr Pro  Val Asp Thr 
    1115                 1120                 1125             


Ser Ile  Pro Val Thr Thr Ser  Thr Glu Ala Ser Ser  Ser Pro Thr 
    1130                 1135                 1140             


Thr Ala  Glu Gly Thr Ser Ile  Pro Thr Ser Pro Pro  Ser Glu Gly 
    1145                 1150                 1155             


Thr Thr  Pro Leu Ala Ser Met  Pro Val Ser Thr Thr  Leu Val Val 
    1160                 1165                 1170             


Ser Ser  Glu Ala Asn Thr Leu  Ser Thr Thr Pro Val  Asp Ser Lys 
    1175                 1180                 1185             


Thr Gln  Val Ala Thr Ser Thr  Glu Ala Ser Ser Pro  Pro Pro Thr 
    1190                 1195                 1200             


Ala Glu  Val Thr Ser Met Pro  Thr Ser Thr Pro Gly  Glu Arg Ser 
    1205                 1210                 1215             


Thr Pro  Leu Thr Ser Met Pro  Val Arg His Thr Pro  Val Ala Ser 
    1220                 1225                 1230             


Ser Glu  Ala Ser Thr Leu Ser  Thr Ser Pro Val Asp  Thr Ser Thr 
    1235                 1240                 1245             


Pro Val  Thr Thr Ser Ala Glu  Thr Ser Ser Ser Pro  Thr Thr Ala 
    1250                 1255                 1260             


Glu Gly  Thr Ser Leu Pro Thr  Ser Thr Thr Ser Glu  Gly Ser Thr 
    1265                 1270                 1275             


Leu Leu  Thr Ser Ile Pro Val  Ser Thr Thr Leu Val  Thr Ser Pro 
    1280                 1285                 1290             


Glu Ala  Ser Thr Leu Leu Thr  Thr Pro Val Asp Thr  Lys Gly Pro 
    1295                 1300                 1305             


Val Val  Thr Ser Asn Glu Val  Ser Ser Ser Pro Thr  Pro Ala Glu 
    1310                 1315                 1320             


Gly Thr  Ser Met Pro Thr Ser  Thr Tyr Ser Glu Gly  Arg Thr Pro 
    1325                 1330                 1335             


Leu Thr  Ser Ile Pro Val Asn  Thr Thr Leu Val Ala  Ser Ser Ala 
    1340                 1345                 1350             


Ile Ser  Ile Leu Ser Thr Thr  Pro Val Asp Asn Ser  Thr Pro Val 
    1355                 1360                 1365             


Thr Thr  Ser Thr Glu Ala Cys  Ser Ser Pro Thr Thr  Ser Glu Gly 
    1370                 1375                 1380             


Thr Ser  Met Pro Asn Ser Asn  Pro Ser Glu Gly Thr  Thr Pro Leu 
    1385                 1390                 1395             


Thr Ser  Ile Pro Val Ser Thr  Thr Pro Val Val Ser  Ser Glu Ala 
    1400                 1405                 1410             


Ser Thr  Leu Ser Ala Thr Pro  Val Asp Thr Ser Thr  Pro Gly Thr 
    1415                 1420                 1425             


Thr Ser  Ala Glu Ala Thr Ser  Ser Pro Thr Thr Ala  Glu Gly Ile 
    1430                 1435                 1440             


Ser Ile  Pro Thr Ser Thr Pro  Ser Glu Gly Lys Thr  Pro Leu Lys 
    1445                 1450                 1455             


Ser Ile  Pro Val Ser Asn Thr  Pro Val Ala Asn Ser  Glu Ala Ser 
    1460                 1465                 1470             


Thr Leu  Ser Thr Thr Pro Val  Asp Ser Asn Ser Pro  Val Val Thr 
    1475                 1480                 1485             


Ser Thr  Ala Val Ser Ser Ser  Pro Thr Pro Ala Glu  Gly Thr Ser 
    1490                 1495                 1500             


Ile Ala  Ile Ser Thr Pro Ser  Glu Gly Ser Thr Ala  Leu Thr Ser 
    1505                 1510                 1515             


Ile Pro  Val Ser Thr Thr Thr  Val Ala Ser Ser Glu  Ile Asn Ser 
    1520                 1525                 1530             


Leu Ser  Thr Thr Pro Ala Val  Thr Ser Thr Pro Val  Thr Thr Tyr 
    1535                 1540                 1545             


Ser Gln  Ala Ser Ser Ser Pro  Thr Thr Ala Asp Gly  Thr Ser Met 
    1550                 1555                 1560             


Gln Thr  Ser Thr Tyr Ser Glu  Gly Ser Thr Pro Leu  Thr Ser Leu 
    1565                 1570                 1575             


Pro Val  Ser Thr Met Leu Val  Val Ser Ser Glu Ala  Asn Thr Leu 
    1580                 1585                 1590             


Ser Thr  Thr Pro Ile Asp Ser  Lys Thr Gln Val Thr  Ala Ser Thr 
    1595                 1600                 1605             


Glu Ala  Ser Ser Ser Thr Thr  Ala Glu Gly Ser Ser  Met Thr Ile 
    1610                 1615                 1620             


Ser Thr  Pro Ser Glu Gly Ser  Pro Leu Leu Thr Ser  Ile Pro Val 
    1625                 1630                 1635             


Ser Thr  Thr Pro Val Ala Ser  Pro Glu Ala Ser Thr  Leu Ser Thr 
    1640                 1645                 1650             


Thr Pro  Val Asp Ser Asn Ser  Pro Val Ile Thr Ser  Thr Glu Val 
    1655                 1660                 1665             


Ser Ser  Ser Pro Thr Pro Ala  Glu Gly Thr Ser Met  Pro Thr Ser 
    1670                 1675                 1680             


Thr Tyr  Thr Glu Gly Arg Thr  Pro Leu Thr Ser Ile  Thr Val Arg 
    1685                 1690                 1695             


Thr Thr  Pro Val Ala Ser Ser  Ala Ile Ser Thr Leu  Ser Thr Thr 
    1700                 1705                 1710             


Pro Val  Asp Asn Ser Thr Pro  Val Thr Thr Ser Thr  Glu Ala Arg 
    1715                 1720                 1725             


Ser Ser  Pro Thr Thr Ser Glu  Gly Thr Ser Met Pro  Asn Ser Thr 
    1730                 1735                 1740             


Pro Ser  Glu Gly Thr Thr Pro  Leu Thr Ser Ile Pro  Val Ser Thr 
    1745                 1750                 1755             


Thr Pro  Val Leu Ser Ser Glu  Ala Ser Thr Leu Ser  Ala Thr Pro 
    1760                 1765                 1770             


Ile Asp  Thr Ser Thr Pro Val  Thr Thr Ser Thr Glu  Ala Thr Ser 
    1775                 1780                 1785             


Ser Pro  Thr Thr Ala Glu Gly  Thr Ser Ile Pro Thr  Ser Thr Leu 
    1790                 1795                 1800             


Ser Glu  Gly Met Thr Pro Leu  Thr Ser Thr Pro Val  Ser His Thr 
    1805                 1810                 1815             


Leu Val  Ala Asn Ser Glu Ala  Ser Thr Leu Ser Thr  Thr Pro Val 
    1820                 1825                 1830             


Asp Ser  Asn Ser Pro Val Val  Thr Ser Thr Ala Val  Ser Ser Ser 
    1835                 1840                 1845             


Pro Thr  Pro Ala Glu Gly Thr  Ser Ile Ala Thr Ser  Thr Pro Ser 
    1850                 1855                 1860             


Glu Gly  Ser Thr Ala Leu Thr  Ser Ile Pro Val Ser  Thr Thr Thr 
    1865                 1870                 1875             


Val Ala  Ser Ser Glu Thr Asn  Thr Leu Ser Thr Thr  Pro Ala Val 
    1880                 1885                 1890             


Thr Ser  Thr Pro Val Thr Thr  Tyr Ala Gln Val Ser  Ser Ser Pro 
    1895                 1900                 1905             


Thr Thr  Ala Asp Gly Ser Ser  Met Pro Thr Ser Thr  Pro Arg Glu 
    1910                 1915                 1920             


Gly Arg  Pro Pro Leu Thr Ser  Ile Pro Val Ser Thr  Thr Thr Val 
    1925                 1930                 1935             


Ala Ser  Ser Glu Ile Asn Thr  Leu Ser Thr Thr Leu  Ala Asp Thr 
    1940                 1945                 1950             


Arg Thr  Pro Val Thr Thr Tyr  Ser Gln Ala Ser Ser  Ser Pro Thr 
    1955                 1960                 1965             


Thr Ala  Asp Gly Thr Ser Met  Pro Thr Pro Ala Tyr  Ser Glu Gly 
    1970                 1975                 1980             


Ser Thr  Pro Leu Thr Ser Met  Pro Leu Ser Thr Thr  Leu Val Val 
    1985                 1990                 1995             


Ser Ser  Glu Ala Ser Thr Leu  Ser Thr Thr Pro Val  Asp Thr Ser 
    2000                 2005                 2010             


Thr Pro  Ala Thr Thr Ser Thr  Glu Gly Ser Ser Ser  Pro Thr Thr 
    2015                 2020                 2025             


Ala Gly  Gly Thr Ser Ile Gln  Thr Ser Thr Pro Ser  Glu Arg Thr 
    2030                 2035                 2040             


Thr Pro  Leu Ala Gly Met Pro  Val Ser Thr Thr Leu  Val Val Ser 
    2045                 2050                 2055             


Ser Glu  Gly Asn Thr Leu Ser  Thr Thr Pro Val Asp  Ser Lys Thr 
    2060                 2065                 2070             


Gln Val  Thr Asn Ser Thr Glu  Ala Ser Ser Ser Ala  Thr Ala Glu 
    2075                 2080                 2085             


Gly Ser  Ser Met Thr Ile Ser  Ala Pro Ser Glu Gly  Ser Pro Leu 
    2090                 2095                 2100             


Leu Thr  Ser Ile Pro Leu Ser  Thr Thr Pro Val Ala  Ser Pro Glu 
    2105                 2110                 2115             


Ala Ser  Thr Leu Ser Thr Thr  Pro Val Asp Ser Asn  Ser Pro Val 
    2120                 2125                 2130             


Ile Thr  Ser Thr Glu Val Ser  Ser Ser Pro Ile Pro  Thr Glu Gly 
    2135                 2140                 2145             


Thr Ser  Met Gln Thr Ser Thr  Tyr Ser Asp Arg Arg  Thr Pro Leu 
    2150                 2155                 2160             


Thr Ser  Met Pro Val Ser Thr  Thr Val Val Ala Ser  Ser Ala Ile 
    2165                 2170                 2175             


Ser Thr  Leu Ser Thr Thr Pro  Val Asp Thr Ser Thr  Pro Val Thr 
    2180                 2185                 2190             


Asn Ser  Thr Glu Ala Arg Ser  Ser Pro Thr Thr Ser  Glu Gly Thr 
    2195                 2200                 2205             


Ser Met  Pro Thr Ser Thr Pro  Ser Glu Gly Ser Thr  Pro Phe Thr 
    2210                 2215                 2220             


Ser Met  Pro Val Ser Thr Met  Pro Val Val Thr Ser  Glu Ala Ser 
    2225                 2230                 2235             


Thr Leu  Ser Ala Thr Pro Val  Asp Thr Ser Thr Pro  Val Thr Thr 
    2240                 2245                 2250             


Ser Thr  Glu Ala Thr Ser Ser  Pro Thr Thr Ala Glu  Gly Thr Ser 
    2255                 2260                 2265             


Ile Pro  Thr Ser Thr Leu Ser  Glu Gly Thr Thr Pro  Leu Thr Ser 
    2270                 2275                 2280             


Ile Pro  Val Ser His Thr Leu  Val Ala Asn Ser Glu  Val Ser Thr 
    2285                 2290                 2295             


Leu Ser  Thr Thr Pro Val Asp  Ser Asn Thr Pro Phe  Thr Thr Ser 
    2300                 2305                 2310             


Thr Glu  Ala Ser Ser Pro Pro  Pro Thr Ala Glu Gly  Thr Ser Met 
    2315                 2320                 2325             


Pro Thr  Ser Thr Ser Ser Glu  Gly Asn Thr Pro Leu  Thr Arg Met 
    2330                 2335                 2340             


Pro Val  Ser Thr Thr Met Val  Ala Ser Phe Glu Thr  Ser Thr Leu 
    2345                 2350                 2355             


Ser Thr  Thr Pro Ala Asp Thr  Ser Thr Pro Val Thr  Thr Tyr Ser 
    2360                 2365                 2370             


Gln Ala  Gly Ser Ser Pro Thr  Thr Ala Asp Asp Thr  Ser Met Pro 
    2375                 2380                 2385             


Thr Ser  Thr Tyr Ser Glu Gly  Ser Thr Pro Leu Thr  Ser Val Pro 
    2390                 2395                 2400             


Val Ser  Thr Met Pro Val Val  Ser Ser Glu Ala Ser  Thr His Ser 
    2405                 2410                 2415             


Thr Thr  Pro Val Asp Thr Ser  Thr Pro Val Thr Thr  Ser Thr Glu 
    2420                 2425                 2430             


Ala Ser  Ser Ser Pro Thr Thr  Ala Glu Gly Thr Ser  Ile Pro Thr 
    2435                 2440                 2445             


Ser Pro  Pro Ser Glu Gly Thr  Thr Pro Leu Ala Ser  Met Pro Val 
    2450                 2455                 2460             


Ser Thr  Thr Pro Val Val Ser  Ser Glu Ala Gly Thr  Leu Ser Thr 
    2465                 2470                 2475             


Thr Pro  Val Asp Thr Ser Thr  Pro Met Thr Thr Ser  Thr Glu Ala 
    2480                 2485                 2490             


Ser Ser  Ser Pro Thr Thr Ala  Glu Asp Ile Val Val  Pro Ile Ser 
    2495                 2500                 2505             


Thr Ala  Ser Glu Gly Ser Thr  Leu Leu Thr Ser Ile  Pro Val Ser 
    2510                 2515                 2520             


Thr Thr  Pro Val Ala Ser Pro  Glu Ala Ser Thr Leu  Ser Thr Thr 
    2525                 2530                 2535             


Pro Val  Asp Ser Asn Ser Pro  Val Val Thr Ser Thr  Glu Ile Ser 
    2540                 2545                 2550             


Ser Ser  Ala Thr Ser Ala Glu  Gly Thr Ser Met Pro  Thr Ser Thr 
    2555                 2560                 2565             


Tyr Ser  Glu Gly Ser Thr Pro  Leu Arg Ser Met Pro  Val Ser Thr 
    2570                 2575                 2580             


Lys Pro  Leu Ala Ser Ser Glu  Ala Ser Thr Leu Ser  Thr Thr Pro 
    2585                 2590                 2595             


Val Asp  Thr Ser Ile Pro Val  Thr Thr Ser Thr Glu  Thr Ser Ser 
    2600                 2605                 2610             


Ser Pro  Thr Thr Ala Lys Asp  Thr Ser Met Pro Ile  Ser Thr Pro 
    2615                 2620                 2625             


Ser Glu  Val Ser Thr Ser Leu  Thr Ser Ile Leu Val  Ser Thr Met 
    2630                 2635                 2640             


Pro Val  Ala Ser Ser Glu Ala  Ser Thr Leu Ser Thr  Thr Pro Val 
    2645                 2650                 2655             


Asp Thr  Arg Thr Leu Val Thr  Thr Ser Thr Gly Thr  Ser Ser Ser 
    2660                 2665                 2670             


Pro Thr  Thr Ala Glu Gly Ser  Ser Met Pro Thr Ser  Thr Pro Gly 
    2675                 2680                 2685             


Glu Arg  Ser Thr Pro Leu Thr  Asn Ile Leu Val Ser  Thr Thr Leu 
    2690                 2695                 2700             


Leu Ala  Asn Ser Glu Ala Ser  Thr Leu Ser Thr Thr  Pro Val Asp 
    2705                 2710                 2715             


Thr Ser  Thr Pro Val Thr Thr  Ser Ala Glu Ala Ser  Ser Ser Pro 
    2720                 2725                 2730             


Thr Thr  Ala Glu Gly Thr Ser  Met Arg Ile Ser Thr  Pro Ser Asp 
    2735                 2740                 2745             


Gly Ser  Thr Pro Leu Thr Ser  Ile Leu Val Ser Thr  Leu Pro Val 
    2750                 2755                 2760             


Ala Ser  Ser Glu Ala Ser Thr  Val Ser Thr Thr Ala  Val Asp Thr 
    2765                 2770                 2775             


Ser Ile  Pro Val Thr Thr Ser  Thr Glu Ala Ser Ser  Ser Pro Thr 
    2780                 2785                 2790             


Thr Ala  Glu Val Thr Ser Met  Pro Thr Ser Thr Pro  Ser Glu Thr 
    2795                 2800                 2805             


Ser Thr  Pro Leu Thr Ser Met  Pro Val Asn His Thr  Pro Val Ala 
    2810                 2815                 2820             


Ser Ser  Glu Ala Gly Thr Leu  Ser Thr Thr Pro Val  Asp Thr Ser 
    2825                 2830                 2835             


Thr Pro  Val Thr Thr Ser Thr  Lys Ala Ser Ser Ser  Pro Thr Thr 
    2840                 2845                 2850             


Ala Glu  Gly Ile Val Val Pro  Ile Ser Thr Ala Ser  Glu Gly Ser 
    2855                 2860                 2865             


Thr Leu  Leu Thr Ser Ile Pro  Val Ser Thr Thr Pro  Val Ala Ser 
    2870                 2875                 2880             


Ser Glu  Ala Ser Thr Leu Ser  Thr Thr Pro Val Asp  Thr Ser Ile 
    2885                 2890                 2895             


Pro Val  Thr Thr Ser Thr Glu  Gly Ser Ser Ser Pro  Thr Thr Ala 
    2900                 2905                 2910             


Glu Gly  Thr Ser Met Pro Ile  Ser Thr Pro Ser Glu  Val Ser Thr 
    2915                 2920                 2925             


Pro Leu  Thr Ser Ile Leu Val  Ser Thr Val Pro Val  Ala Gly Ser 
    2930                 2935                 2940             


Glu Ala  Ser Thr Leu Ser Thr  Thr Pro Val Asp Thr  Arg Thr Pro 
    2945                 2950                 2955             


Val Thr  Thr Ser Ala Glu Ala  Ser Ser Ser Pro Thr  Thr Ala Glu 
    2960                 2965                 2970             


Gly Thr  Ser Met Pro Ile Ser  Thr Pro Gly Glu Arg  Arg Thr Pro 
    2975                 2980                 2985             


Leu Thr  Ser Met Ser Val Ser  Thr Met Pro Val Ala  Ser Ser Glu 
    2990                 2995                 3000             


Ala Ser  Thr Leu Ser Arg Thr  Pro Ala Asp Thr Ser  Thr Pro Val 
    3005                 3010                 3015             


Thr Thr  Ser Thr Glu Ala Ser  Ser Ser Pro Thr Thr  Ala Glu Gly 
    3020                 3025                 3030             


Thr Gly  Ile Pro Ile Ser Thr  Pro Ser Glu Gly Ser  Thr Pro Leu 
    3035                 3040                 3045             


Thr Ser  Ile Pro Val Ser Thr  Thr Pro Val Ala Ile  Pro Glu Ala 
    3050                 3055                 3060             


Ser Thr  Leu Ser Thr Thr Pro  Val Asp Ser Asn Ser  Pro Val Val 
    3065                 3070                 3075             


Thr Ser  Thr Glu Val Ser Ser  Ser Pro Thr Pro Ala  Glu Gly Thr 
    3080                 3085                 3090             


Ser Met  Pro Ile Ser Thr Tyr  Ser Glu Gly Ser Thr  Pro Leu Thr 
    3095                 3100                 3105             


Gly Val  Pro Val Ser Thr Thr  Pro Val Thr Ser Ser  Ala Ile Ser 
    3110                 3115                 3120             


Thr Leu  Ser Thr Thr Pro Val  Asp Thr Ser Thr Pro  Val Thr Thr 
    3125                 3130                 3135             


Ser Thr  Glu Ala His Ser Ser  Pro Thr Thr Ser Glu  Gly Thr Ser 
    3140                 3145                 3150             


Met Pro  Thr Ser Thr Pro Ser  Glu Gly Ser Thr Pro  Leu Thr Tyr 
    3155                 3160                 3165             


Met Pro  Val Ser Thr Met Leu  Val Val Ser Ser Glu  Asp Ser Thr 
    3170                 3175                 3180             


Leu Ser  Ala Thr Pro Val Asp  Thr Ser Thr Pro Val  Thr Thr Ser 
    3185                 3190                 3195             


Thr Glu  Ala Thr Ser Ser Thr  Thr Ala Glu Gly Thr  Ser Ile Pro 
    3200                 3205                 3210             


Thr Ser  Thr Pro Ser Glu Gly  Met Thr Pro Leu Thr  Ser Val Pro 
    3215                 3220                 3225             


Val Ser  Asn Thr Pro Val Ala  Ser Ser Glu Ala Ser  Ile Leu Ser 
    3230                 3235                 3240             


Thr Thr  Pro Val Asp Ser Asn  Thr Pro Leu Thr Thr  Ser Thr Glu 
    3245                 3250                 3255             


Ala Ser  Ser Ser Pro Pro Thr  Ala Glu Gly Thr Ser  Met Pro Thr 
    3260                 3265                 3270             


Ser Thr  Pro Ser Glu Gly Ser  Thr Pro Leu Thr Ser  Met Pro Val 
    3275                 3280                 3285             


Ser Thr  Thr Thr Val Ala Ser  Ser Glu Thr Ser Thr  Leu Ser Thr 
    3290                 3295                 3300             


Thr Pro  Ala Asp Thr Ser Thr  Pro Val Thr Thr Tyr  Ser Gln Ala 
    3305                 3310                 3315             


Ser Ser  Ser Pro Pro Ile Ala  Asp Gly Thr Ser Met  Pro Thr Ser 
    3320                 3325                 3330             


Thr Tyr  Ser Glu Gly Ser Thr  Pro Leu Thr Asn Met  Ser Phe Ser 
    3335                 3340                 3345             


Thr Thr  Pro Val Val Ser Ser  Glu Ala Ser Thr Leu  Ser Thr Thr 
    3350                 3355                 3360             


Pro Val  Asp Thr Ser Thr Pro  Val Thr Thr Ser Thr  Glu Ala Ser 
    3365                 3370                 3375             


Leu Ser  Pro Thr Thr Ala Glu  Gly Thr Ser Ile Pro  Thr Ser Ser 
    3380                 3385                 3390             


Pro Ser  Glu Gly Thr Thr Pro  Leu Ala Ser Met Pro  Val Ser Thr 
    3395                 3400                 3405             


Thr Pro  Val Val Ser Ser Glu  Val Asn Thr Leu Ser  Thr Thr Pro 
    3410                 3415                 3420             


Val Asp  Ser Asn Thr Leu Val  Thr Thr Ser Thr Glu  Ala Ser Ser 
    3425                 3430                 3435             


Ser Pro  Thr Ile Ala Glu Gly  Thr Ser Leu Pro Thr  Ser Thr Thr 
    3440                 3445                 3450             


Ser Glu  Gly Ser Thr Pro Leu  Ser Ile Met Pro Leu  Ser Thr Thr 
    3455                 3460                 3465             


Pro Val  Ala Ser Ser Glu Ala  Ser Thr Leu Ser Thr  Thr Pro Val 
    3470                 3475                 3480             


Asp Thr  Ser Thr Pro Val Thr  Thr Ser Ser Pro Thr  Asn Ser Ser 
    3485                 3490                 3495             


Pro Thr  Thr Ala Glu Val Thr  Ser Met Pro Thr Ser  Thr Ala Gly 
    3500                 3505                 3510             


Glu Gly  Ser Thr Pro Leu Thr  Asn Met Pro Val Ser  Thr Thr Pro 
    3515                 3520                 3525             


Val Ala  Ser Ser Glu Ala Ser  Thr Leu Ser Thr Thr  Pro Val Asp 
    3530                 3535                 3540             


Ser Asn  Thr Phe Val Thr Ser  Ser Ser Gln Ala Ser  Ser Ser Pro 
    3545                 3550                 3555             


Ala Thr  Leu Gln Val Thr Thr  Met Arg Met Ser Thr  Pro Ser Glu 
    3560                 3565                 3570             


Gly Ser  Ser Ser Leu Thr Thr  Met Leu Leu Ser Ser  Thr Tyr Val 
    3575                 3580                 3585             


Thr Ser  Ser Glu Ala Ser Thr  Pro Ser Thr Pro Ser  Val Asp Arg 
    3590                 3595                 3600             


Ser Thr  Pro Val Thr Thr Ser  Thr Gln Ser Asn Ser  Thr Pro Thr 
    3605                 3610                 3615             


Pro Pro  Glu Val Ile Thr Leu  Pro Met Ser Thr Pro  Ser Glu Val 
    3620                 3625                 3630             


Ser Thr  Pro Leu Thr Ile Met  Pro Val Ser Thr Thr  Ser Val Thr 
    3635                 3640                 3645             


Ile Ser  Glu Ala Gly Thr Ala  Ser Thr Leu Pro Val  Asp Thr Ser 
    3650                 3655                 3660             


Thr Pro  Val Ile Thr Ser Thr  Gln Val Ser Ser Ser  Pro Val Thr 
    3665                 3670                 3675             


Pro Glu  Gly Thr Thr Met Pro  Ile Trp Thr Pro Ser  Glu Gly Ser 
    3680                 3685                 3690             


Thr Pro  Leu Thr Thr Met Pro  Val Ser Thr Thr Arg  Val Thr Ser 
    3695                 3700                 3705             


Ser Glu  Gly Ser Thr Leu Ser  Thr Pro Ser Val Val  Thr Ser Thr 
    3710                 3715                 3720             


Pro Val  Thr Thr Ser Thr Glu  Ala Ile Ser Ser Ser  Ala Thr Leu 
    3725                 3730                 3735             


Asp Ser  Thr Thr Met Ser Val  Ser Met Pro Met Glu  Ile Ser Thr 
    3740                 3745                 3750             


Leu Gly  Thr Thr Ile Leu Val  Ser Thr Thr Pro Val  Thr Arg Phe 
    3755                 3760                 3765             


Pro Glu  Ser Ser Thr Pro Ser  Ile Pro Ser Val Tyr  Thr Ser Met 
    3770                 3775                 3780             


Ser Met  Thr Thr Ala Ser Glu  Gly Ser Ser Ser Pro  Thr Thr Leu 
    3785                 3790                 3795             


Glu Gly  Thr Thr Thr Met Pro  Met Ser Thr Thr Ser  Glu Arg Ser 
    3800                 3805                 3810             


Thr Leu  Leu Thr Thr Val Leu  Ile Ser Pro Ile Ser  Val Met Ser 
    3815                 3820                 3825             


Pro Ser  Glu Ala Ser Thr Leu  Ser Thr Pro Pro Gly  Asp Thr Ser 
    3830                 3835                 3840             


Thr Pro  Leu Leu Thr Ser Thr  Lys Ala Gly Ser Phe  Ser Ile Pro 
    3845                 3850                 3855             


Ala Glu  Val Thr Thr Ile Arg  Ile Ser Ile Thr Ser  Glu Arg Ser 
    3860                 3865                 3870             


Thr Pro  Leu Thr Thr Leu Leu  Val Ser Thr Thr Leu  Pro Thr Ser 
    3875                 3880                 3885             


Phe Pro  Gly Ala Ser Ile Ala  Ser Thr Pro Pro Leu  Asp Thr Ser 
    3890                 3895                 3900             


Thr Thr  Phe Thr Pro Ser Thr  Asp Thr Ala Ser Thr  Pro Thr Ile 
    3905                 3910                 3915             


Pro Val  Ala Thr Thr Ile Ser  Val Ser Val Ile Thr  Glu Gly Ser 
    3920                 3925                 3930             


Thr Pro  Gly Thr Thr Ile Phe  Ile Pro Ser Thr Pro  Val Thr Ser 
    3935                 3940                 3945             


Ser Thr  Ala Asp Val Phe Pro  Ala Thr Thr Gly Ala  Val Ser Thr 
    3950                 3955                 3960             


Pro Val  Ile Thr Ser Thr Glu  Leu Asn Thr Pro Ser  Thr Ser Ser 
    3965                 3970                 3975             


Ser Ser  Thr Thr Thr Ser Phe  Ser Thr Thr Lys Glu  Phe Thr Thr 
    3980                 3985                 3990             


Pro Ala  Met Thr Thr Ala Ala  Pro Leu Thr Tyr Val  Thr Met Ser 
    3995                 4000                 4005             


Thr Ala  Pro Ser Thr Pro Arg  Thr Thr Ser Arg Gly  Cys Thr Thr 
    4010                 4015                 4020             


Ser Ala  Ser Thr Leu Ser Ala  Thr Ser Thr Pro His  Thr Ser Thr 
    4025                 4030                 4035             


Ser Val  Thr Thr Arg Pro Val  Thr Pro Ser Ser Glu  Ser Ser Arg 
    4040                 4045                 4050             


Pro Ser  Thr Ile Thr Ser His  Thr Ile Pro Pro Thr  Phe Pro Pro 
    4055                 4060                 4065             


Ala His  Ser Ser Thr Pro Pro  Thr Thr Ser Ala Ser  Ser Thr Thr 
    4070                 4075                 4080             


Val Asn  Pro Glu Ala Val Thr  Thr Met Thr Thr Arg  Thr Lys Pro 
    4085                 4090                 4095             


Ser Thr  Arg Thr Thr Ser Phe  Pro Thr Val Thr Thr  Thr Ala Val 
    4100                 4105                 4110             


Pro Thr  Asn Thr Thr Ile Lys  Ser Asn Pro Thr Ser  Thr Pro Thr 
    4115                 4120                 4125             


Val Pro  Arg Thr Thr Thr Cys  Phe Gly Asp Gly Cys  Gln Asn Thr 
    4130                 4135                 4140             


Ala Ser  Arg Cys Lys Asn Gly  Gly Thr Trp Asp Gly  Leu Lys Cys 
    4145                 4150                 4155             


Gln Cys  Pro Asn Leu Tyr Tyr  Gly Glu Leu Cys Glu  Glu Val Val 
    4160                 4165                 4170             


Ser Ser  Ile Asp Ile Gly Pro  Pro Glu Thr Ile Ser  Ala Gln Met 
    4175                 4180                 4185             


Glu Leu  Thr Val Thr Val Thr  Ser Val Lys Phe Thr  Glu Glu Leu 
    4190                 4195                 4200             


Lys Asn  His Ser Ser Gln Glu  Phe Gln Glu Phe Lys  Gln Thr Phe 
    4205                 4210                 4215             


Thr Glu  Gln Met Asn Ile Val  Tyr Ser Gly Ile Pro  Glu Tyr Val 
    4220                 4225                 4230             


Gly Val  Asn Ile Thr Lys Leu  Arg Leu Gly Ser Val  Val Val Glu 
    4235                 4240                 4245             


His Asp  Val Leu Leu Arg Thr  Lys Tyr Thr Pro Glu  Tyr Lys Thr 
    4250                 4255                 4260             


Val Leu  Asp Asn Ala Thr Glu  Val Val Lys Glu Lys  Ile Thr Lys 
    4265                 4270                 4275             


Val Thr  Thr Gln Gln Ile Met  Ile Asn Asp Ile Cys  Ser Asp Met 
    4280                 4285                 4290             


Met Cys  Phe Asn Thr Thr Gly  Thr Gln Val Gln Asn  Ile Thr Val 
    4295                 4300                 4305             


Thr Gln  Tyr Asp Pro Glu Glu  Asp Cys Arg Lys Met  Ala Lys Glu 
    4310                 4315                 4320             


Tyr Gly  Asp Tyr Phe Val Val  Glu Tyr Arg Asp Gln  Lys Pro Tyr 
    4325                 4330                 4335             


Cys Ile  Ser Pro Cys Glu Pro  Gly Phe Ser Val Ser  Lys Asn Cys 
    4340                 4345                 4350             


Asn Leu  Gly Lys Cys Gln Met  Ser Leu Ser Gly Pro  Gln Cys Leu 
    4355                 4360                 4365             


Cys Val  Thr Thr Glu Thr His  Trp Tyr Ser Gly Glu  Thr Cys Asn 
    4370                 4375                 4380             


Gln Gly  Thr Gln Lys Ser Leu  Val Tyr Gly Leu Val  Gly Ala Gly 
    4385                 4390                 4395             


Val Val  Leu Met Leu Ile Ile  Leu Val Ala Leu Leu  Met Leu Val 
    4400                 4405                 4410             


Phe Arg  Ser Lys Arg Glu Val  Lys Arg Gln Lys Tyr  Arg Leu Ser 
    4415                 4420                 4425             


Gln Leu  Tyr Lys Trp Gln Glu  Glu Asp Ser Gly Pro  Ala Pro Gly 
    4430                 4435                 4440             


Thr Phe  Gln Asn Ile Gly Phe  Asp Ile Cys Gln Asp  Asp Asp Ser 
    4445                 4450                 4455             


Ile His  Leu Glu Ser Ile Tyr  Ser Asn Phe Gln Pro  Ser Leu Arg 
    4460                 4465                 4470             


His Ile  Asp Pro Glu Thr Lys  Ile Arg Ile Gln Arg  Pro Gln Val 
    4475                 4480                 4485             


Met Thr  Thr Ser Phe 
    4490             


<210>  836
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  836

Met Ala Thr Trp Asp Glu Lys Ala Val Thr Arg Arg Ala Lys Val Ala 
1               5                   10                  15      


Pro Ala Glu Arg Met Ser Lys Phe Leu Arg His Phe Thr Val Val Gly 
            20                  25                  30          


Asp Asp Tyr His Ala Trp Asn Ile Asn Tyr Lys Lys Trp Glu Asn Glu 
        35                  40                  45              


Glu Glu Glu Glu Glu Glu Glu Gln Pro Pro Pro Thr Pro Val Ser Gly 
    50                  55                  60                  


Glu Glu Gly Arg Ala Ala Ala Pro Asp Val Ala Pro Ala Pro Gly Pro 
65                  70                  75                  80  


Ala Pro Arg Ala Pro Leu Asp Phe Arg Gly Met Leu Arg Lys Leu Phe 
                85                  90                  95      


Ser Ser His Arg Phe Gln Val Ile Ile Ile Cys Leu Val Val Leu Asp 
            100                 105                 110         


Ala Leu Leu Val Leu Ala Glu Leu Ile Leu Asp Leu Lys Ile Ile Gln 
        115                 120                 125             


Pro Asp Lys Asn Asn Tyr Ala Ala Met Val Phe His Tyr Met Ser Ile 
    130                 135                 140                 


Thr Ile Leu Val Phe Phe Met Met Glu Ile Ile Phe Lys Leu Phe Val 
145                 150                 155                 160 


Phe Arg Leu Glu Phe Phe His His Lys Phe Glu Ile Leu Asp Ala Val 
                165                 170                 175     


Val Val Val Val Ser Phe Ile Leu Asp Ile Val Leu Leu Phe Gln Glu 
            180                 185                 190         


His Gln Phe Glu Ala Leu Gly Leu Leu Ile Leu Leu Arg Leu Trp Arg 
        195                 200                 205             


Val Ala Arg Ile Ile Asn Gly Ile Ile Ile Ser Val Lys Thr Arg Ser 
    210                 215                 220                 


Glu Arg Gln Leu Leu Arg Leu Lys Gln Met Asn Val Gln Leu Ala Ala 
225                 230                 235                 240 


Lys Ile Gln His Leu Glu Phe Ser Cys Ser Glu Lys Glu Gln Glu Ile 
                245                 250                 255     


Glu Arg Leu Asn Lys Leu Leu Arg Gln His Gly Leu Leu Gly Glu Val 
            260                 265                 270         


Asn 
    


<210>  837
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  837

Met Val Ser Arg Lys Ala Val Ala Ala Leu Leu Val Val His Val Ala 
1               5                   10                  15      


Ala Met Leu Ala Ser Gln Thr Glu Ala Phe Val Pro Ile Phe Thr Tyr 
            20                  25                  30          


Gly Glu Leu Gln Arg Met Gln Glu Lys Glu Arg Asn Lys Gly Gln Lys 
        35                  40                  45              


Lys Ser Leu Ser Val Trp Gln Arg Ser Gly Glu Glu Gly Pro Val Asp 
    50                  55                  60                  


Pro Ala Glu Pro Ile Arg Glu Glu Glu Asn Glu Met Ile Lys Leu Thr 
65                  70                  75                  80  


Ala Pro Leu Glu Ile Gly Met Arg Met Asn Ser Arg Gln Leu Glu Lys 
                85                  90                  95      


Tyr Pro Ala Thr Leu Glu Gly Leu Leu Ser Glu Met Leu Pro Gln His 
            100                 105                 110         


Ala Lys 
        


<210>  838
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  838

Met Val Trp Lys Lys Leu Gly Ser Arg Asn Phe Ser Ser Cys Pro Ser 
1               5                   10                  15      


Gly Ser Ile Gln Trp Ile Trp Asp Val Leu Gly Glu Cys Ala Gln Asp 
            20                  25                  30          


Gly Trp Asp Glu Ala Ser Val Gly Leu Gly Leu Ile Ser Ile Leu Cys 
        35                  40                  45              


Phe Ala Ala Ser Thr Phe Pro Gln Phe Ile Lys Ala Tyr Lys Thr Gly 
    50                  55                  60                  


Asn Met Asp Gln Ala Leu Ser Leu Trp Phe Leu Leu Gly Trp Ile Gly 
65                  70                  75                  80  


Gly Asp Ser Cys Asn Leu Ile Gly Ser Phe Leu Ala Asp Gln Leu Pro 
                85                  90                  95      


Leu Gln Thr Tyr Thr Ala Val Tyr Tyr Val Leu Ala Asp Leu Val Met 
            100                 105                 110         


Leu Thr Leu Tyr Phe Tyr Tyr Lys Phe Arg Thr Arg Pro Ser Leu Leu 
        115                 120                 125             


Ser Ala Pro Ile Asn Ser Val Leu Leu Phe Leu Met Gly Met Ala Cys 
    130                 135                 140                 


Ala Thr Pro Leu Leu Ser Ala Ala Gly Pro Val Ala Ala Pro Arg Glu 
145                 150                 155                 160 


Ala Phe Arg Gly Arg Ala Leu Leu Ser Val Glu Ser Gly Ser Lys Pro 
                165                 170                 175     


Phe Thr Arg Gln Glu Val Ile Gly Phe Val Ile Gly Ser Ile Ser Ser 
            180                 185                 190         


Val Leu Tyr Leu Leu Ser Arg Leu Pro Gln Ile Arg Thr Asn Phe Leu 
        195                 200                 205             


Arg Lys Ser Thr Gln Gly Ile Ser Tyr Ser Leu Phe Ala Leu Val Met 
    210                 215                 220                 


Leu Gly Asn Thr Leu Tyr Gly Leu Ser Val Leu Leu Lys Asn Pro Glu 
225                 230                 235                 240 


Glu Gly Gln Ser Glu Gly Ser Tyr Leu Leu His His Leu Pro Trp Leu 
                245                 250                 255     


Val Gly Ser Leu Gly Val Leu Leu Leu Asp Thr Ile Ile Ser Ile Gln 
            260                 265                 270         


Phe Leu Val Tyr Arg Arg Ser Thr Ala Ala Ser Glu Leu Glu Pro Leu 
        275                 280                 285             


Leu Pro Ser 
    290     


<210>  839
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  839

Met Asp Gln Ala Leu Ser Leu Trp Phe Leu Leu Gly Trp Ile Gly Gly 
1               5                   10                  15      


Asp Ser Cys Asn Leu Ile Gly Ser Phe Leu Ala Asp Gln Leu Pro Leu 
            20                  25                  30          


Gln Thr Tyr Thr Ala Val Tyr Tyr Val Leu Ala Asp Leu Val Met Leu 
        35                  40                  45              


Thr Leu Tyr Phe Tyr Tyr Lys Phe Arg Thr Arg Pro Ser Leu Leu Ser 
    50                  55                  60                  


Ala Pro Ile Asn Ser Val Leu Leu Phe Leu Met Gly Met Ala Cys Ala 
65                  70                  75                  80  


Thr Pro Leu Leu Ser Ala Ala Gly Pro Val Ala Ala Pro Arg Glu Ala 
                85                  90                  95      


Phe Arg Gly Arg Ala Leu Leu Ser Val Glu Ser Gly Ser Lys Pro Phe 
            100                 105                 110         


Thr Arg Gln Glu Val Ile Gly Phe Val Ile Gly Ser Ile Ser Ser Val 
        115                 120                 125             


Leu Tyr Leu Leu Ser Arg Leu Pro Gln Ile Arg Thr Asn Phe Leu Arg 
    130                 135                 140                 


Lys Ser Thr Gln Gly Ile Ser Tyr Ser Leu Phe Ala Leu Val Met Leu 
145                 150                 155                 160 


Gly Asn Thr Leu Tyr Gly Leu Ser Val Leu Leu Lys Asn Pro Glu Glu 
                165                 170                 175     


Gly Gln Ser Glu Gly Ser Tyr Leu Leu His His Leu Pro Trp Leu Val 
            180                 185                 190         


Gly Ser Leu Gly Val Leu Leu Leu Asp Thr Ile Ile Ser Ile Gln Phe 
        195                 200                 205             


Leu Val Tyr Arg Arg Ser Thr Ala Ala Ser Glu Leu Glu Pro Leu Leu 
    210                 215                 220                 


Pro Ser 
225     


<210>  840
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  840

Met Ala Ala Phe Pro His Lys Ile Ile Phe Phe Leu Val Cys Ser Thr 
1               5                   10                  15      


Leu Thr His Val Ala Phe Ser Gly Ile Phe Asn Lys Arg Asp Phe Thr 
            20                  25                  30          


Arg Trp Pro Lys Pro Arg Cys Lys Met Tyr Ile Pro Leu Asp Pro Asp 
        35                  40                  45              


Tyr Asn Ala Asp Cys Pro Asn Val Thr Ala Pro Val Cys Ala Ser Asn 
    50                  55                  60                  


Gly His Thr Phe Gln Asn Glu Cys Phe Phe Cys Val Glu Gln Arg Glu 
65                  70                  75                  80  


Phe His Tyr Arg Ile Lys Phe Glu Lys Tyr Gly Lys Cys Asp 
                85                  90                  


<210>  841
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  841

Met Asp Asn Val Gln Pro Lys Ile Lys His Arg Pro Phe Cys Phe Ser 
1               5                   10                  15      


Val Lys Gly His Val Lys Met Leu Arg Leu Ala Leu Thr Val Thr Ser 
            20                  25                  30          


Met Thr Phe Phe Ile Ile Ala Gln Ala Pro Glu Pro Tyr Ile Val Ile 
        35                  40                  45              


Thr Gly Phe Glu Val Thr Val Ile Leu Phe Phe Ile Leu Leu Tyr Val 
    50                  55                  60                  


Leu Arg Leu Asp Arg Leu Met Lys Trp Leu Phe Trp Pro Leu Leu Asp 
65                  70                  75                  80  


Ile Ile Asn Ser Leu Val Thr Thr Val Phe Met Leu Ile Val Ser Val 
                85                  90                  95      


Leu Ala Leu Ile Pro Glu Thr Thr Thr Leu Thr Val Gly Gly Gly Leu 
            100                 105                 110         


Phe 
    


<210>  842
<211>  2005
<212>  PRT
<213>  Homo sapiens

<400>  842

Met Ala Gln Ser Val Leu Val Pro Pro Gly Pro Asp Ser Phe Arg Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Arg Pro Lys Gln Glu Arg Lys Asp Glu Asp Asp Glu Asn 
        35                  40                  45              


Gly Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Ser Leu Pro Phe 
    50                  55                  60                  


Ile Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Val Pro Leu Glu Asp 
65                  70                  75                  80  


Leu Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys 
                85                  90                  95      


Gly Lys Ala Ile Ser Arg Phe Ser Ala Thr Pro Ala Leu Tyr Ile Leu 
            100                 105                 110         


Thr Pro Phe Asn Pro Ile Arg Lys Leu Ala Ile Lys Ile Leu Val His 
        115                 120                 125             


Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val 
    130                 135                 140                 


Phe Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr 
145                 150                 155                 160 


Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala 
                165                 170                 175     


Arg Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn 
            180                 185                 190         


Trp Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val 
        195                 200                 205             


Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala 
    210                 215                 220                 


Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala 
225                 230                 235                 240 


Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val 
                245                 250                 255     


Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly 
            260                 265                 270         


Asn Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Asp Asn Ser Ser Phe 
        275                 280                 285             


Glu Ile Asn Ile Thr Ser Phe Phe Asn Asn Ser Leu Asp Gly Asn Gly 
    290                 295                 300                 


Thr Thr Phe Asn Arg Thr Val Ser Ile Phe Asn Trp Asp Glu Tyr Ile 
305                 310                 315                 320 


Glu Asp Lys Ser His Phe Tyr Phe Leu Glu Gly Gln Asn Asp Ala Leu 
                325                 330                 335     


Leu Cys Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile 
            340                 345                 350         


Cys Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp 
        355                 360                 365             


Thr Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp 
    370                 375                 380                 


Phe Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr 
385                 390                 395                 400 


Tyr Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu 
                405                 410                 415     


Ile Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn 
            420                 425                 430         


Gln Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln 
        435                 440                 445             


Met Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Ala Ala 
    450                 455                 460                 


Ala Ala Ala Ser Ala Glu Ser Arg Asp Phe Ser Gly Ala Gly Gly Ile 
465                 470                 475                 480 


Gly Val Phe Ser Glu Ser Ser Ser Val Ala Ser Lys Leu Ser Ser Lys 
                485                 490                 495     


Ser Glu Lys Glu Leu Lys Asn Arg Arg Lys Lys Lys Lys Gln Lys Glu 
            500                 505                 510         


Gln Ser Gly Glu Glu Glu Lys Asn Asp Arg Val Arg Lys Ser Glu Ser 
        515                 520                 525             


Glu Asp Ser Ile Arg Arg Lys Gly Phe Arg Phe Ser Leu Glu Gly Ser 
    530                 535                 540                 


Arg Leu Thr Tyr Glu Lys Arg Phe Ser Ser Pro His Gln Ser Leu Leu 
545                 550                 555                 560 


Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Ala Ser 
                565                 570                 575     


Leu Phe Ser Phe Arg Gly Arg Ala Lys Asp Ile Gly Ser Glu Asn Asp 
            580                 585                 590         


Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Asn Asp Ser Arg Arg 
        595                 600                 605             


Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg His Ser Asn 
    610                 615                 620                 


Val Ser Gln Ala Ser Arg Ala Ser Arg Val Leu Pro Ile Leu Pro Met 
625                 630                 635                 640 


Asn Gly Lys Met His Ser Ala Val Asp Cys Asn Gly Val Val Ser Leu 
                645                 650                 655     


Val Gly Gly Pro Ser Thr Leu Thr Ser Ala Gly Gln Leu Leu Pro Glu 
            660                 665                 670         


Gly Thr Thr Thr Glu Thr Glu Ile Arg Lys Arg Arg Ser Ser Ser Tyr 
        675                 680                 685             


His Val Ser Met Asp Leu Leu Glu Asp Pro Thr Ser Arg Gln Arg Ala 
    690                 695                 700                 


Met Ser Ile Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu Glu 
705                 710                 715                 720 


Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Lys Phe Ala Asn Met Cys 
                725                 730                 735     


Leu Ile Trp Asp Cys Cys Lys Pro Trp Leu Lys Val Lys His Leu Val 
            740                 745                 750         


Asn Leu Val Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
        755                 760                 765             


Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met Thr 
    770                 775                 780                 


Glu Gln Phe Ser Ser Val Leu Ser Val Gly Asn Leu Val Phe Thr Gly 
785                 790                 795                 800 


Ile Phe Thr Ala Glu Met Phe Leu Lys Ile Ile Ala Met Asp Pro Tyr 
                805                 810                 815     


Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Phe Ile Val Ser 
            820                 825                 830         


Leu Ser Leu Met Glu Leu Gly Leu Ala Asn Val Glu Gly Leu Ser Val 
        835                 840                 845             


Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
    850                 855                 860                 


Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
865                 870                 875                 880 


Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 
                885                 890                 895     


Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys 
            900                 905                 910         


Lys Ile Ser Asn Asp Cys Glu Leu Pro Arg Trp His Met His Asp Phe 
        915                 920                 925             


Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile 
    930                 935                 940                 


Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys Leu 
945                 950                 955                 960 


Thr Val Phe Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn 
                965                 970                 975     


Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Ala 
            980                 985                 990         


Ala Thr Asp Asp Asp Asn Glu Met  Asn Asn Leu Gln Ile  Ala Val Gly 
        995                 1000                 1005             


Arg Met  Gln Lys Gly Ile Asp  Phe Val Lys Arg Lys  Ile Arg Glu 
    1010                 1015                 1020             


Phe Ile  Gln Lys Ala Phe Val  Arg Lys Gln Lys Ala  Leu Asp Glu 
    1025                 1030                 1035             


Ile Lys  Pro Leu Glu Asp Leu  Asn Asn Lys Lys Asp  Ser Cys Ile 
    1040                 1045                 1050             


Ser Asn  His Thr Thr Ile Glu  Ile Gly Lys Asp Leu  Asn Tyr Leu 
    1055                 1060                 1065             


Lys Asp  Gly Asn Gly Thr Thr  Ser Gly Ile Gly Ser  Ser Val Glu 
    1070                 1075                 1080             


Lys Tyr  Val Val Asp Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn 
    1085                 1090                 1095             


Pro Ser  Leu Thr Val Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp 
    1100                 1105                 1110             


Phe Glu  Asn Leu Asn Thr Glu  Glu Phe Ser Ser Glu  Ser Asp Met 
    1115                 1120                 1125             


Glu Glu  Ser Lys Glu Lys Leu  Asn Ala Thr Ser Ser  Ser Glu Gly 
    1130                 1135                 1140             


Ser Thr  Val Asp Ile Gly Ala  Pro Ala Glu Gly Glu  Gln Pro Glu 
    1145                 1150                 1155             


Val Glu  Pro Glu Glu Ser Leu  Glu Pro Glu Ala Cys  Phe Thr Glu 
    1160                 1165                 1170             


Asp Cys  Val Arg Lys Phe Lys  Cys Cys Gln Ile Ser  Ile Glu Glu 
    1175                 1180                 1185             


Gly Lys  Gly Lys Leu Trp Trp  Asn Leu Arg Lys Thr  Cys Tyr Lys 
    1190                 1195                 1200             


Ile Val  Glu His Asn Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile 
    1205                 1210                 1215             


Leu Leu  Ser Ser Gly Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Glu 
    1220                 1225                 1230             


Gln Arg  Lys Thr Ile Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val 
    1235                 1240                 1245             


Phe Thr  Tyr Ile Phe Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala 
    1250                 1255                 1260             


Tyr Gly  Phe Gln Val Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp 
    1265                 1270                 1275             


Phe Leu  Ile Val Asp Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala 
    1280                 1285                 1290             


Leu Gly  Tyr Ser Glu Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu 
    1295                 1300                 1305             


Arg Ala  Leu Arg Pro Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met 
    1310                 1315                 1320             


Arg Val  Val Val Asn Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met 
    1325                 1330                 1335             


Asn Val  Leu Leu Val Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile 
    1340                 1345                 1350             


Met Gly  Val Asn Leu Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn 
    1355                 1360                 1365             


Tyr Thr  Thr Gly Glu Met Phe  Asp Val Ser Val Val  Asn Asn Tyr 
    1370                 1375                 1380             


Ser Glu  Cys Lys Ala Leu Ile  Glu Ser Asn Gln Thr  Ala Arg Trp 
    1385                 1390                 1395             


Lys Asn  Val Lys Val Asn Phe  Asp Asn Val Gly Leu  Gly Tyr Leu 
    1400                 1405                 1410             


Ser Leu  Leu Gln Val Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met 
    1415                 1420                 1425             


Tyr Ala  Ala Val Asp Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr 
    1430                 1435                 1440             


Glu Asp  Asn Leu Tyr Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile 
    1445                 1450                 1455             


Phe Gly  Ser Phe Phe Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile 
    1460                 1465                 1470             


Asp Asn  Phe Asn Gln Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile 
    1475                 1480                 1485             


Phe Met  Thr Glu Glu Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys 
    1490                 1495                 1500             


Leu Gly  Ser Lys Lys Pro Gln  Lys Pro Ile Pro Arg  Pro Ala Asn 
    1505                 1510                 1515             


Lys Phe  Gln Gly Met Val Phe  Asp Phe Val Thr Lys  Gln Val Phe 
    1520                 1525                 1530             


Asp Ile  Ser Ile Met Ile Leu  Ile Cys Leu Asn Met  Val Thr Met 
    1535                 1540                 1545             


Met Val  Glu Thr Asp Asp Gln  Ser Gln Glu Met Thr  Asn Ile Leu 
    1550                 1555                 1560             


Tyr Trp  Ile Asn Leu Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys 
    1565                 1570                 1575             


Val Leu  Lys Leu Ile Ser Leu  Arg Tyr Tyr Tyr Phe  Thr Ile Gly 
    1580                 1585                 1590             


Trp Asn  Ile Phe Asp Phe Val  Val Val Ile Leu Ser  Ile Val Gly 
    1595                 1600                 1605             


Met Phe  Leu Ala Glu Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr 
    1610                 1615                 1620             


Leu Phe  Arg Val Ile Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg 
    1625                 1630                 1635             


Leu Ile  Lys Gly Ala Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu 
    1640                 1645                 1650             


Met Met  Ser Leu Pro Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe 
    1655                 1660                 1665             


Leu Val  Met Phe Ile Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala 
    1670                 1675                 1680             


Tyr Val  Lys Arg Glu Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu 
    1685                 1690                 1695             


Thr Phe  Gly Asn Ser Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser 
    1700                 1705                 1710             


Ala Gly  Trp Asp Gly Leu Leu  Ala Pro Ile Leu Asn  Ser Gly Pro 
    1715                 1720                 1725             


Pro Asp  Cys Asp Pro Asp Lys  Asp His Pro Gly Ser  Ser Val Lys 
    1730                 1735                 1740             


Gly Asp  Cys Gly Asn Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser 
    1745                 1750                 1755             


Tyr Ile  Ile Ile Ser Phe Leu  Val Val Val Asn Met  Tyr Ile Ala 
    1760                 1765                 1770             


Val Ile  Leu Glu Asn Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu 
    1775                 1780                 1785             


Pro Leu  Ser Glu Asp Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu 
    1790                 1795                 1800             


Lys Phe  Asp Pro Asp Ala Thr  Gln Phe Ile Glu Phe  Ala Lys Leu 
    1805                 1810                 1815             


Ser Asp  Phe Ala Asp Ala Leu  Asp Pro Pro Leu Leu  Ile Ala Lys 
    1820                 1825                 1830             


Pro Asn  Lys Val Gln Leu Ile  Ala Met Asp Leu Pro  Met Val Ser 
    1835                 1840                 1845             


Gly Asp  Arg Ile His Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys 
    1850                 1855                 1860             


Arg Val  Leu Gly Glu Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln 
    1865                 1870                 1875             


Met Glu  Glu Arg Phe Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr 
    1880                 1885                 1890             


Glu Pro  Ile Thr Thr Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser 
    1895                 1900                 1905             


Ala Ile  Ile Ile Gln Arg Ala  Tyr Arg Arg Tyr Leu  Leu Lys Gln 
    1910                 1915                 1920             


Lys Val  Lys Lys Val Ser Ser  Ile Tyr Lys Lys Asp  Lys Gly Lys 
    1925                 1930                 1935             


Glu Cys  Asp Gly Thr Pro Ile  Lys Glu Asp Thr Leu  Ile Asp Lys 
    1940                 1945                 1950             


Leu Asn  Glu Asn Ser Thr Pro  Glu Lys Thr Asp Met  Thr Pro Ser 
    1955                 1960                 1965             


Thr Thr  Ser Pro Pro Ser Tyr  Asp Ser Val Thr Lys  Pro Glu Lys 
    1970                 1975                 1980             


Glu Lys  Phe Glu Lys Asp Lys  Ser Glu Lys Glu Asp  Lys Gly Lys 
    1985                 1990                 1995             


Asp Ile  Arg Glu Ser Lys Lys  
    2000                 2005 


<210>  843
<211>  2005
<212>  PRT
<213>  Homo sapiens

<400>  843

Met Ala Gln Ser Val Leu Val Pro Pro Gly Pro Asp Ser Phe Arg Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Arg Pro Lys Gln Glu Arg Lys Asp Glu Asp Asp Glu Asn 
        35                  40                  45              


Gly Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Ser Leu Pro Phe 
    50                  55                  60                  


Ile Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Val Pro Leu Glu Asp 
65                  70                  75                  80  


Leu Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys 
                85                  90                  95      


Gly Lys Ala Ile Ser Arg Phe Ser Ala Thr Pro Ala Leu Tyr Ile Leu 
            100                 105                 110         


Thr Pro Phe Asn Pro Ile Arg Lys Leu Ala Ile Lys Ile Leu Val His 
        115                 120                 125             


Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val 
    130                 135                 140                 


Phe Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr 
145                 150                 155                 160 


Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala 
                165                 170                 175     


Arg Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn 
            180                 185                 190         


Trp Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val 
        195                 200                 205             


Asn Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala 
    210                 215                 220                 


Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala 
225                 230                 235                 240 


Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val 
                245                 250                 255     


Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly 
            260                 265                 270         


Asn Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Asp Asn Ser Ser Phe 
        275                 280                 285             


Glu Ile Asn Ile Thr Ser Phe Phe Asn Asn Ser Leu Asp Gly Asn Gly 
    290                 295                 300                 


Thr Thr Phe Asn Arg Thr Val Ser Ile Phe Asn Trp Asp Glu Tyr Ile 
305                 310                 315                 320 


Glu Asp Lys Ser His Phe Tyr Phe Leu Glu Gly Gln Asn Asp Ala Leu 
                325                 330                 335     


Leu Cys Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile 
            340                 345                 350         


Cys Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp 
        355                 360                 365             


Thr Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp 
    370                 375                 380                 


Phe Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr 
385                 390                 395                 400 


Tyr Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu 
                405                 410                 415     


Ile Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn 
            420                 425                 430         


Gln Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln 
        435                 440                 445             


Met Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Ala Ala 
    450                 455                 460                 


Ala Ala Ala Ser Ala Glu Ser Arg Asp Phe Ser Gly Ala Gly Gly Ile 
465                 470                 475                 480 


Gly Val Phe Ser Glu Ser Ser Ser Val Ala Ser Lys Leu Ser Ser Lys 
                485                 490                 495     


Ser Glu Lys Glu Leu Lys Asn Arg Arg Lys Lys Lys Lys Gln Lys Glu 
            500                 505                 510         


Gln Ser Gly Glu Glu Glu Lys Asn Asp Arg Val Arg Lys Ser Glu Ser 
        515                 520                 525             


Glu Asp Ser Ile Arg Arg Lys Gly Phe Arg Phe Ser Leu Glu Gly Ser 
    530                 535                 540                 


Arg Leu Thr Tyr Glu Lys Arg Phe Ser Ser Pro His Gln Ser Leu Leu 
545                 550                 555                 560 


Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Ala Ser 
                565                 570                 575     


Leu Phe Ser Phe Arg Gly Arg Ala Lys Asp Ile Gly Ser Glu Asn Asp 
            580                 585                 590         


Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Asn Asp Ser Arg Arg 
        595                 600                 605             


Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg His Ser Asn 
    610                 615                 620                 


Val Ser Gln Ala Ser Arg Ala Ser Arg Val Leu Pro Ile Leu Pro Met 
625                 630                 635                 640 


Asn Gly Lys Met His Ser Ala Val Asp Cys Asn Gly Val Val Ser Leu 
                645                 650                 655     


Val Gly Gly Pro Ser Thr Leu Thr Ser Ala Gly Gln Leu Leu Pro Glu 
            660                 665                 670         


Gly Thr Thr Thr Glu Thr Glu Ile Arg Lys Arg Arg Ser Ser Ser Tyr 
        675                 680                 685             


His Val Ser Met Asp Leu Leu Glu Asp Pro Thr Ser Arg Gln Arg Ala 
    690                 695                 700                 


Met Ser Ile Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu Glu 
705                 710                 715                 720 


Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Lys Phe Ala Asn Met Cys 
                725                 730                 735     


Leu Ile Trp Asp Cys Cys Lys Pro Trp Leu Lys Val Lys His Leu Val 
            740                 745                 750         


Asn Leu Val Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
        755                 760                 765             


Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met Thr 
    770                 775                 780                 


Glu Gln Phe Ser Ser Val Leu Ser Val Gly Asn Leu Val Phe Thr Gly 
785                 790                 795                 800 


Ile Phe Thr Ala Glu Met Phe Leu Lys Ile Ile Ala Met Asp Pro Tyr 
                805                 810                 815     


Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Phe Ile Val Ser 
            820                 825                 830         


Leu Ser Leu Met Glu Leu Gly Leu Ala Asn Val Glu Gly Leu Ser Val 
        835                 840                 845             


Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
    850                 855                 860                 


Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
865                 870                 875                 880 


Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 
                885                 890                 895     


Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys 
            900                 905                 910         


Lys Ile Ser Asn Asp Cys Glu Leu Pro Arg Trp His Met His Asp Phe 
        915                 920                 925             


Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile 
    930                 935                 940                 


Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys Leu 
945                 950                 955                 960 


Thr Val Phe Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn 
                965                 970                 975     


Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Ala 
            980                 985                 990         


Ala Thr Asp Asp Asp Asn Glu Met  Asn Asn Leu Gln Ile  Ala Val Gly 
        995                 1000                 1005             


Arg Met  Gln Lys Gly Ile Asp  Phe Val Lys Arg Lys  Ile Arg Glu 
    1010                 1015                 1020             


Phe Ile  Gln Lys Ala Phe Val  Arg Lys Gln Lys Ala  Leu Asp Glu 
    1025                 1030                 1035             


Ile Lys  Pro Leu Glu Asp Leu  Asn Asn Lys Lys Asp  Ser Cys Ile 
    1040                 1045                 1050             


Ser Asn  His Thr Thr Ile Glu  Ile Gly Lys Asp Leu  Asn Tyr Leu 
    1055                 1060                 1065             


Lys Asp  Gly Asn Gly Thr Thr  Ser Gly Ile Gly Ser  Ser Val Glu 
    1070                 1075                 1080             


Lys Tyr  Val Val Asp Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn 
    1085                 1090                 1095             


Pro Ser  Leu Thr Val Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp 
    1100                 1105                 1110             


Phe Glu  Asn Leu Asn Thr Glu  Glu Phe Ser Ser Glu  Ser Asp Met 
    1115                 1120                 1125             


Glu Glu  Ser Lys Glu Lys Leu  Asn Ala Thr Ser Ser  Ser Glu Gly 
    1130                 1135                 1140             


Ser Thr  Val Asp Ile Gly Ala  Pro Ala Glu Gly Glu  Gln Pro Glu 
    1145                 1150                 1155             


Val Glu  Pro Glu Glu Ser Leu  Glu Pro Glu Ala Cys  Phe Thr Glu 
    1160                 1165                 1170             


Asp Cys  Val Arg Lys Phe Lys  Cys Cys Gln Ile Ser  Ile Glu Glu 
    1175                 1180                 1185             


Gly Lys  Gly Lys Leu Trp Trp  Asn Leu Arg Lys Thr  Cys Tyr Lys 
    1190                 1195                 1200             


Ile Val  Glu His Asn Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile 
    1205                 1210                 1215             


Leu Leu  Ser Ser Gly Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Glu 
    1220                 1225                 1230             


Gln Arg  Lys Thr Ile Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val 
    1235                 1240                 1245             


Phe Thr  Tyr Ile Phe Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala 
    1250                 1255                 1260             


Tyr Gly  Phe Gln Val Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp 
    1265                 1270                 1275             


Phe Leu  Ile Val Asp Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala 
    1280                 1285                 1290             


Leu Gly  Tyr Ser Glu Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu 
    1295                 1300                 1305             


Arg Ala  Leu Arg Pro Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met 
    1310                 1315                 1320             


Arg Val  Val Val Asn Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met 
    1325                 1330                 1335             


Asn Val  Leu Leu Val Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile 
    1340                 1345                 1350             


Met Gly  Val Asn Leu Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn 
    1355                 1360                 1365             


Tyr Thr  Thr Gly Glu Met Phe  Asp Val Ser Val Val  Asn Asn Tyr 
    1370                 1375                 1380             


Ser Glu  Cys Lys Ala Leu Ile  Glu Ser Asn Gln Thr  Ala Arg Trp 
    1385                 1390                 1395             


Lys Asn  Val Lys Val Asn Phe  Asp Asn Val Gly Leu  Gly Tyr Leu 
    1400                 1405                 1410             


Ser Leu  Leu Gln Val Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met 
    1415                 1420                 1425             


Tyr Ala  Ala Val Asp Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr 
    1430                 1435                 1440             


Glu Asp  Asn Leu Tyr Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile 
    1445                 1450                 1455             


Phe Gly  Ser Phe Phe Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile 
    1460                 1465                 1470             


Asp Asn  Phe Asn Gln Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile 
    1475                 1480                 1485             


Phe Met  Thr Glu Glu Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys 
    1490                 1495                 1500             


Leu Gly  Ser Lys Lys Pro Gln  Lys Pro Ile Pro Arg  Pro Ala Asn 
    1505                 1510                 1515             


Lys Phe  Gln Gly Met Val Phe  Asp Phe Val Thr Lys  Gln Val Phe 
    1520                 1525                 1530             


Asp Ile  Ser Ile Met Ile Leu  Ile Cys Leu Asn Met  Val Thr Met 
    1535                 1540                 1545             


Met Val  Glu Thr Asp Asp Gln  Ser Gln Glu Met Thr  Asn Ile Leu 
    1550                 1555                 1560             


Tyr Trp  Ile Asn Leu Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys 
    1565                 1570                 1575             


Val Leu  Lys Leu Ile Ser Leu  Arg Tyr Tyr Tyr Phe  Thr Ile Gly 
    1580                 1585                 1590             


Trp Asn  Ile Phe Asp Phe Val  Val Val Ile Leu Ser  Ile Val Gly 
    1595                 1600                 1605             


Met Phe  Leu Ala Glu Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr 
    1610                 1615                 1620             


Leu Phe  Arg Val Ile Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg 
    1625                 1630                 1635             


Leu Ile  Lys Gly Ala Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu 
    1640                 1645                 1650             


Met Met  Ser Leu Pro Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe 
    1655                 1660                 1665             


Leu Val  Met Phe Ile Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala 
    1670                 1675                 1680             


Tyr Val  Lys Arg Glu Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu 
    1685                 1690                 1695             


Thr Phe  Gly Asn Ser Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser 
    1700                 1705                 1710             


Ala Gly  Trp Asp Gly Leu Leu  Ala Pro Ile Leu Asn  Ser Gly Pro 
    1715                 1720                 1725             


Pro Asp  Cys Asp Pro Asp Lys  Asp His Pro Gly Ser  Ser Val Lys 
    1730                 1735                 1740             


Gly Asp  Cys Gly Asn Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser 
    1745                 1750                 1755             


Tyr Ile  Ile Ile Ser Phe Leu  Val Val Val Asn Met  Tyr Ile Ala 
    1760                 1765                 1770             


Val Ile  Leu Glu Asn Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu 
    1775                 1780                 1785             


Pro Leu  Ser Glu Asp Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu 
    1790                 1795                 1800             


Lys Phe  Asp Pro Asp Ala Thr  Gln Phe Ile Glu Phe  Ala Lys Leu 
    1805                 1810                 1815             


Ser Asp  Phe Ala Asp Ala Leu  Asp Pro Pro Leu Leu  Ile Ala Lys 
    1820                 1825                 1830             


Pro Asn  Lys Val Gln Leu Ile  Ala Met Asp Leu Pro  Met Val Ser 
    1835                 1840                 1845             


Gly Asp  Arg Ile His Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys 
    1850                 1855                 1860             


Arg Val  Leu Gly Glu Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln 
    1865                 1870                 1875             


Met Glu  Glu Arg Phe Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr 
    1880                 1885                 1890             


Glu Pro  Ile Thr Thr Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser 
    1895                 1900                 1905             


Ala Ile  Ile Ile Gln Arg Ala  Tyr Arg Arg Tyr Leu  Leu Lys Gln 
    1910                 1915                 1920             


Lys Val  Lys Lys Val Ser Ser  Ile Tyr Lys Lys Asp  Lys Gly Lys 
    1925                 1930                 1935             


Glu Cys  Asp Gly Thr Pro Ile  Lys Glu Asp Thr Leu  Ile Asp Lys 
    1940                 1945                 1950             


Leu Asn  Glu Asn Ser Thr Pro  Glu Lys Thr Asp Met  Thr Pro Ser 
    1955                 1960                 1965             


Thr Thr  Ser Pro Pro Ser Tyr  Asp Ser Val Thr Lys  Pro Glu Lys 
    1970                 1975                 1980             


Glu Lys  Phe Glu Lys Asp Lys  Ser Glu Lys Glu Asp  Lys Gly Lys 
    1985                 1990                 1995             


Asp Ile  Arg Glu Ser Lys Lys  
    2000                 2005 


<210>  844
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  844

Met Pro Ala Phe Asn Arg Leu Phe Pro Leu Ala Ser Leu Val Leu Ile 
1               5                   10                  15      


Tyr Trp Val Ser Val Cys Phe Pro Val Cys Val Glu Val Pro Ser Glu 
            20                  25                  30          


Thr Glu Ala Val Gln Gly Asn Pro Met Lys Leu Arg Cys Ile Ser Cys 
        35                  40                  45              


Met Lys Arg Glu Glu Val Glu Ala Thr Thr Val Val Glu Trp Phe Tyr 
    50                  55                  60                  


Arg Pro Glu Gly Gly Lys Asp Phe Leu Ile Tyr Glu Tyr Arg Asn Gly 
65                  70                  75                  80  


His Gln Glu Val Glu Ser Pro Phe Gln Gly Arg Leu Gln Trp Asn Gly 
                85                  90                  95      


Ser Lys Asp Leu Gln Asp Val Ser Ile Thr Val Leu Asn Val Thr Leu 
            100                 105                 110         


Asn Asp Ser Gly Leu Tyr Thr Cys Asn Val Ser Arg Glu Phe Glu Phe 
        115                 120                 125             


Glu Ala His Arg Pro Phe Val Lys Thr Thr Arg Leu Ile Pro Leu Arg 
    130                 135                 140                 


Val Thr Glu Glu Ala Gly Glu Asp Phe Thr Ser Val Val Ser Glu Ile 
145                 150                 155                 160 


Met Met Tyr Ile Leu Leu Val Phe Leu Thr Leu Trp Leu Leu Ile Glu 
                165                 170                 175     


Met Ile Tyr Cys Tyr Arg Lys Val Ser Lys Ala Glu Glu Ala Ala Gln 
            180                 185                 190         


Glu Asn Ala Ser Asp Tyr Leu Ala Ile Pro Ser Glu Asn Lys Glu Asn 
        195                 200                 205             


Ser Ala Val Pro Val Glu Glu 
    210                 215 


<210>  845
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  845

Met Leu Lys Val Ser Ala Val Leu Cys Val Cys Ala Ala Ala Trp Cys 
1               5                   10                  15      


Ser Gln Ser Leu Ala Ala Ala Ala Ala Val Ala Ala Ala Gly Gly Arg 
            20                  25                  30          


Ser Asp Gly Gly Asn Phe Leu Asp Asp Lys Gln Trp Leu Thr Thr Ile 
        35                  40                  45              


Ser Gln Tyr Asp Lys Glu Val Gly Gln Trp Asn Lys Phe Arg Asp Asp 
    50                  55                  60                  


Asp Tyr Phe Arg Thr Trp Ser Pro Gly Lys Pro Phe Asp Gln Ala Leu 
65                  70                  75                  80  


Asp Pro Ala Lys Asp Pro Cys Leu Lys Met Lys Cys Ser Arg His Lys 
                85                  90                  95      


Val Cys Ile Ala Gln Asp Ser Gln Thr Ala Val Cys Ile Ser His Arg 
            100                 105                 110         


Arg Leu Thr His Arg Met Lys Glu Ala Gly Val Asp His Arg Gln Trp 
        115                 120                 125             


Arg Gly Pro Ile Leu Ser Thr Cys Lys Gln Cys Pro Val Val Tyr Pro 
    130                 135                 140                 


Ser Pro Val Cys Gly Ser Asp Gly His Thr Tyr Ser Phe Gln Cys Lys 
145                 150                 155                 160 


Leu Glu Tyr Gln Ala Cys Val Leu Gly Lys Gln Ile Ser Val Lys Cys 
                165                 170                 175     


Glu Gly His Cys Pro Cys Pro Ser Asp Lys Pro Thr Ser Thr Ser Arg 
            180                 185                 190         


Asn Val Lys Arg Ala Cys Ser Asp Leu Glu Phe Arg Glu Val Ala Asn 
        195                 200                 205             


Arg Leu Arg Asp Trp Phe Lys Ala Leu His Glu Ser Gly Ser Gln Asn 
    210                 215                 220                 


Lys Lys Thr Lys Thr Leu Leu Arg Pro Glu Arg Ser Arg Phe Asp Thr 
225                 230                 235                 240 


Ser Ile Leu Pro Ile Cys Lys Asp Ser Leu Gly Trp Met Phe Asn Arg 
                245                 250                 255     


Leu Asp Thr Asn Tyr Asp Leu Leu Leu Asp Gln Ser Glu Leu Arg Ser 
            260                 265                 270         


Ile Tyr Leu Asp Lys Asn Glu Gln Cys Thr Lys Ala Phe Phe Asn Ser 
        275                 280                 285             


Cys Asp Thr Tyr Lys Asp Ser Leu Ile Ser Asn Asn Glu Trp Cys Tyr 
    290                 295                 300                 


Cys Phe Gln Arg Gln Gln Asp Pro Pro Cys Gln Thr Glu Leu Ser Asn 
305                 310                 315                 320 


Ile Gln Lys Arg Gln Gly Val Lys Lys Leu Leu Gly Gln Tyr Ile Pro 
                325                 330                 335     


Leu Cys Asp Glu Asp Gly Tyr Tyr Lys Pro Thr Gln Cys His Gly Ser 
            340                 345                 350         


Val Gly Gln Cys Trp Cys Val Asp Arg Tyr Gly Asn Glu Val Met Gly 
        355                 360                 365             


Ser Arg Ile Asn Gly Val Ala Asp Cys Ala Ile Asp Phe Glu Ile Ser 
    370                 375                 380                 


Gly Asp Phe Ala Ser Gly Asp Phe His Glu Trp Thr Asp Asp Glu Asp 
385                 390                 395                 400 


Asp Glu Asp Asp Ile Met Asn Asp Glu Asp Glu Ile Glu Asp Asp Asp 
                405                 410                 415     


Glu Asp Glu Gly Asp Asp Asp Asp Gly Gly Asp Asp His Asp Val Tyr 
            420                 425                 430         


Ile 
    


<210>  846
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  846

Met Leu Lys Arg Cys Gly Arg Arg Leu Leu Leu Ala Leu Ala Gly Ala 
1               5                   10                  15      


Leu Leu Ala Cys Leu Leu Val Leu Thr Ala Asp Pro Pro Pro Pro Pro 
            20                  25                  30          


Leu Pro Ala Glu Arg Gly Arg Arg Ala Leu Arg Ser Leu Ala Gly Pro 
        35                  40                  45              


Ala Gly Ala Ala Pro Ala Pro Gly Leu Gly Ala Ala Ala Ala Ala Pro 
    50                  55                  60                  


Gly Ala Leu Val Arg Asp Val His Ser Leu Ser Glu Tyr Phe Ser Leu 
65                  70                  75                  80  


Leu Thr Arg Ala Arg Arg Asp Ala Gly Pro Pro Pro Gly Ala Ala Pro 
                85                  90                  95      


Arg Pro Ala Asp Gly His Pro Arg Pro Leu Ala Glu Pro Leu Ala Pro 
            100                 105                 110         


Arg Asp Val Phe Ile Ala Val Lys Thr Thr Lys Lys Phe His Arg Ala 
        115                 120                 125             


Arg Leu Asp Leu Leu Leu Glu Thr Trp Ile Ser Arg His Lys Glu Met 
    130                 135                 140                 


Thr Phe Ile Phe Thr Asp Gly Glu Asp Glu Ala Leu Ala Arg His Thr 
145                 150                 155                 160 


Gly Asn Val Val Ile Thr Asn Cys Ser Ala Ala His Ser Arg Gln Ala 
                165                 170                 175     


Leu Ser Cys Lys Met Ala Val Glu Tyr Asp Arg Phe Ile Glu Ser Gly 
            180                 185                 190         


Arg Lys Trp Phe Cys His Val Asp Asp Asp Asn Tyr Val Asn Leu Arg 
        195                 200                 205             


Ala Leu Leu Arg Leu Leu Ala Ser Tyr Pro His Thr Arg Asp Val Tyr 
    210                 215                 220                 


Val Gly Lys Pro Ser Leu Asp Arg Pro Ile Gln Ala Met Glu Arg Val 
225                 230                 235                 240 


Ser Glu Asn Lys Val Arg Pro Val His Phe Trp Phe Ala Thr Gly Gly 
                245                 250                 255     


Ala Gly Phe Cys Ile Ser Arg Gly Leu Ala Leu Lys Met Ser Pro Trp 
            260                 265                 270         


Ala Ser Gly Gly His Phe Met Asn Thr Ala Glu Arg Ile Arg Leu Pro 
        275                 280                 285             


Asp Asp Cys Thr Ile Gly Tyr Ile Val Glu Ala Leu Leu Gly Val Pro 
    290                 295                 300                 


Leu Ile Arg Ser Gly Leu Phe His Ser His Leu Glu Asn Leu Gln Gln 
305                 310                 315                 320 


Val Pro Thr Ser Glu Leu His Glu Gln Val Thr Leu Ser Tyr Gly Met 
                325                 330                 335     


Phe Glu Asn Lys Arg Asn Ala Val His Val Lys Gly Pro Phe Ser Val 
            340                 345                 350         


Glu Ala Asp Pro Ser Arg Phe Arg Ser Ile His Cys His Leu Tyr Pro 
        355                 360                 365             


Asp Thr Pro Trp Cys Pro Arg Thr Ala Ile Phe 
    370                 375                 


<210>  847
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  847

Met Leu Lys Arg Cys Gly Arg Arg Leu Leu Leu Ala Leu Ala Gly Ala 
1               5                   10                  15      


Leu Leu Ala Cys Leu Leu Val Leu Thr Ala Asp Pro Pro Pro Pro Pro 
            20                  25                  30          


Leu Pro Ala Glu Arg Gly Arg Arg Ala Leu Arg Ser Leu Ala Gly Pro 
        35                  40                  45              


Ala Gly Ala Ala Pro Ala Pro Gly Leu Gly Ala Ala Ala Ala Ala Pro 
    50                  55                  60                  


Gly Ala Leu Val Arg Asp Val His Ser Leu Ser Glu Tyr Phe Ser Leu 
65                  70                  75                  80  


Leu Thr Arg Ala Arg Arg Asp Ala Gly Pro Pro Pro Gly Ala Ala Pro 
                85                  90                  95      


Arg Pro Ala Asp Gly His Pro Arg Pro Leu Ala Glu Pro Leu Ala Pro 
            100                 105                 110         


Arg Asp Val Phe Ile Ala Val Lys Thr Thr Lys Lys Phe His Arg Ala 
        115                 120                 125             


Arg Leu Asp Leu Leu Leu Glu Thr Trp Ile Ser Arg His Lys Glu Met 
    130                 135                 140                 


Thr Phe Ile Phe Thr Asp Gly Glu Asp Glu Ala Leu Ala Arg His Thr 
145                 150                 155                 160 


Gly Asn Val Val Ile Thr Asn Cys Ser Ala Ala His Ser Arg Gln Ala 
                165                 170                 175     


Leu Ser Cys Lys Met Ala Val Glu Tyr Asp Arg Phe Ile Glu Ser Gly 
            180                 185                 190         


Arg Lys Trp Phe Cys His Val Asp Asp Asp Asn Tyr Val Asn Leu Arg 
        195                 200                 205             


Ala Leu Leu Arg Leu Leu Ala Ser Tyr Pro His Thr Arg Asp Val Tyr 
    210                 215                 220                 


Val Gly Lys Pro Ser Leu Asp Arg Pro Ile Gln Ala Met Glu Arg Val 
225                 230                 235                 240 


Ser Glu Asn Lys Val Arg Pro Val His Phe Trp Phe Ala Thr Gly Gly 
                245                 250                 255     


Ala Gly Phe Cys Ile Ser Arg Gly Leu Ala Leu Lys Met Ser Pro Trp 
            260                 265                 270         


Ala Ser Gly Gly His Phe Met Asn Thr Ala Glu Arg Ile Arg Leu Pro 
        275                 280                 285             


Asp Asp Cys Thr Ile Gly Tyr Ile Val Glu Ala Leu Leu Gly Val Pro 
    290                 295                 300                 


Leu Ile Arg Ser Gly Leu Phe His Ser His Leu Glu Asn Leu Gln Gln 
305                 310                 315                 320 


Val Pro Thr Ser Glu Leu His Glu Gln Val Thr Leu Ser Tyr Gly Met 
                325                 330                 335     


Phe Glu Asn Lys Arg Asn Ala Val His Val Lys Gly Pro Phe Ser Val 
            340                 345                 350         


Glu Ala Asp Pro Ser Arg Trp Gly Asn 
        355                 360     


<210>  848
<211>  387
<212>  PRT
<213>  Homo sapiens

<400>  848

Met Asp Lys Leu Asp Ala Asn Val Ser Ser Glu Glu Gly Phe Gly Ser 
1               5                   10                  15      


Val Glu Lys Val Val Leu Leu Thr Phe Leu Ser Thr Val Ile Leu Met 
            20                  25                  30          


Ala Ile Leu Gly Asn Leu Leu Val Met Val Ala Val Cys Trp Asp Arg 
        35                  40                  45              


Gln Leu Arg Lys Ile Lys Thr Asn Tyr Phe Ile Val Ser Leu Ala Phe 
    50                  55                  60                  


Ala Asp Leu Leu Val Ser Val Leu Val Met Pro Phe Gly Ala Ile Glu 
65                  70                  75                  80  


Leu Val Gln Asp Ile Trp Ile Tyr Gly Glu Val Phe Cys Leu Val Arg 
                85                  90                  95      


Thr Ser Leu Asp Val Leu Leu Thr Thr Ala Ser Ile Phe His Leu Cys 
            100                 105                 110         


Cys Ile Ser Leu Asp Arg Tyr Tyr Ala Ile Cys Cys Gln Pro Leu Val 
        115                 120                 125             


Tyr Arg Asn Lys Met Thr Pro Leu Arg Ile Ala Leu Met Leu Gly Gly 
    130                 135                 140                 


Cys Trp Val Ile Pro Thr Phe Ile Ser Phe Leu Pro Ile Met Gln Gly 
145                 150                 155                 160 


Trp Asn Asn Ile Gly Ile Ile Asp Leu Ile Glu Lys Arg Lys Phe Asn 
                165                 170                 175     


Gln Asn Ser Asn Ser Thr Tyr Cys Val Phe Met Val Asn Lys Pro Tyr 
            180                 185                 190         


Ala Ile Thr Cys Ser Val Val Ala Phe Tyr Ile Pro Phe Leu Leu Met 
        195                 200                 205             


Val Leu Ala Tyr Tyr Arg Ile Tyr Val Thr Ala Lys Glu His Ala His 
    210                 215                 220                 


Gln Ile Gln Met Leu Gln Arg Ala Gly Ala Ser Ser Glu Ser Arg Pro 
225                 230                 235                 240 


Gln Ser Ala Asp Gln His Ser Thr His Arg Met Arg Thr Glu Thr Lys 
                245                 250                 255     


Ala Ala Lys Thr Leu Cys Ile Ile Met Gly Cys Phe Cys Leu Cys Trp 
            260                 265                 270         


Ala Pro Phe Phe Val Thr Asn Ile Val Asp Pro Phe Ile Asp Tyr Thr 
        275                 280                 285             


Val Pro Gly Gln Val Trp Thr Ala Phe Leu Trp Leu Gly Tyr Ile Asn 
    290                 295                 300                 


Ser Gly Leu Asn Pro Phe Leu Tyr Ala Phe Leu Asn Lys Ser Phe Arg 
305                 310                 315                 320 


Arg Ala Phe Leu Ile Ile Leu Cys Cys Asp Asp Glu Arg Tyr Arg Arg 
                325                 330                 335     


Pro Ser Ile Leu Gly Gln Thr Val Pro Cys Ser Thr Thr Thr Ile Asn 
            340                 345                 350         


Gly Ser Thr His Val Leu Arg Tyr Thr Val Leu His Arg Gly His His 
        355                 360                 365             


Gln Glu Leu Glu Lys Leu Pro Ile His Asn Asp Pro Glu Ser Leu Glu 
    370                 375                 380                 


Ser Cys Phe 
385         


<210>  849
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  849

Met Asp Lys Leu Asp Ala Asn Val Ser Ser Glu Glu Gly Phe Gly Ser 
1               5                   10                  15      


Val Glu Lys Val Val Leu Leu Thr Phe Leu Ser Thr Val Ile Leu Met 
            20                  25                  30          


Ala Ile Leu Gly Asn Leu Leu Val Met Val Ala Val Cys Trp Asp Arg 
        35                  40                  45              


Gln Leu Arg Lys Ile Lys Thr Asn Tyr Phe Ile Val Ser Leu Ala Phe 
    50                  55                  60                  


Ala Asp Leu Leu Val Ser Val Leu Val Met Pro Phe Gly Ala Ile Glu 
65                  70                  75                  80  


Leu Val Gln Asp Ile Trp Ile Tyr Gly Glu Val Phe Cys Leu Val Arg 
                85                  90                  95      


Thr Ser Leu Asp Val Leu Leu Thr Thr Ala Ser Ile Phe His Leu Cys 
            100                 105                 110         


Cys Ile Ser Leu Asp Arg Tyr Tyr Ala Ile Cys Cys Gln Pro Leu Val 
        115                 120                 125             


Tyr Arg Asn Lys Met Thr Pro Leu Arg Ile Ala Leu Met Leu Gly Gly 
    130                 135                 140                 


Cys Trp Val Ile Pro Thr Phe Ile Ser Phe Leu Pro Ile Met Gln Gly 
145                 150                 155                 160 


Trp Asn Asn Ile Gly Ile Ile Asp Leu Ile Glu Lys Arg Lys Phe Asn 
                165                 170                 175     


Gln Asn Ser Asn Ser Thr Tyr Cys Val Phe Met Val Asn Lys Pro Tyr 
            180                 185                 190         


Ala Ile Thr Cys Ser Val Val Ala Phe Tyr Ile Pro Phe Leu Leu Met 
        195                 200                 205             


Val Leu Ala Tyr Tyr Arg Ile Tyr Val Thr Ala Lys Glu His Ala His 
    210                 215                 220                 


Gln Ile Gln Met Leu Gln Arg Ala Gly Ala Ser Ser Glu Ser Arg Pro 
225                 230                 235                 240 


Gln Ser Ala Asp Gln His Ser Thr His Arg Met Arg Thr Glu Thr Lys 
                245                 250                 255     


Ala Ala Lys Thr Leu Cys Ile Ile Met Gly Cys Phe Cys Leu Cys Trp 
            260                 265                 270         


Ala Pro Phe Phe Val Thr Asn Ile Val Asp Pro Phe Ile Asp Tyr Thr 
        275                 280                 285             


Val Pro Gly Gln Val Trp Thr Ala Phe Leu Trp Leu Gly Tyr Ile Asn 
    290                 295                 300                 


Ser Gly Leu Asn Pro Phe Leu Tyr Ala Phe Leu Asn Lys Ser Phe Arg 
305                 310                 315                 320 


Arg Ala Phe Leu Ile Ile Leu Cys Cys Asp Asp Glu Arg Tyr Arg Arg 
                325                 330                 335     


Pro Ser Ile Leu Gly Gln Thr Val Pro Cys Ser Thr Thr Thr Ile Asn 
            340                 345                 350         


Gly Ser Thr His Val Leu Arg Asp Ala Val Glu Cys Gly Gly Gln Trp 
        355                 360                 365             


Glu Ser Gln Cys His Pro Pro Ala Thr Ser Pro Leu Val Ala Ala Gln 
    370                 375                 380                 


Pro Ser Asp Thr 
385             


<210>  850
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  850

Met Asp Lys Leu Asp Ala Asn Val Ser Ser Glu Glu Gly Phe Gly Ser 
1               5                   10                  15      


Val Glu Lys Val Val Leu Leu Thr Phe Leu Ser Thr Val Ile Leu Met 
            20                  25                  30          


Ala Ile Leu Gly Asn Leu Leu Val Met Val Ala Val Cys Trp Asp Arg 
        35                  40                  45              


Gln Leu Arg Lys Ile Lys Thr Asn Tyr Phe Ile Val Ser Leu Ala Phe 
    50                  55                  60                  


Ala Asp Leu Leu Val Ser Val Leu Val Met Pro Phe Gly Ala Ile Glu 
65                  70                  75                  80  


Leu Val Gln Asp Ile Trp Ile Tyr Gly Glu Val Phe Cys Leu Val Arg 
                85                  90                  95      


Thr Ser Leu Asp Val Leu Leu Thr Thr Ala Ser Ile Phe His Leu Cys 
            100                 105                 110         


Cys Ile Ser Leu Asp Arg Tyr Tyr Ala Ile Cys Cys Gln Pro Leu Val 
        115                 120                 125             


Tyr Arg Asn Lys Met Thr Pro Leu Arg Ile Ala Leu Met Leu Gly Gly 
    130                 135                 140                 


Cys Trp Val Ile Pro Thr Phe Ile Ser Phe Leu Pro Ile Met Gln Gly 
145                 150                 155                 160 


Trp Asn Asn Ile Gly Ile Ile Asp Leu Ile Glu Lys Arg Lys Phe Asn 
                165                 170                 175     


Gln Asn Ser Asn Ser Thr Tyr Cys Val Phe Met Val Asn Lys Pro Tyr 
            180                 185                 190         


Ala Ile Thr Cys Ser Val Val Ala Phe Tyr Ile Pro Phe Leu Leu Met 
        195                 200                 205             


Val Leu Ala Tyr Tyr Arg Ile Tyr Val Thr Ala Lys Glu His Ala His 
    210                 215                 220                 


Gln Ile Gln Met Leu Gln Arg Ala Gly Ala Ser Ser Glu Ser Arg Pro 
225                 230                 235                 240 


Gln Ser Ala Asp Gln His Ser Thr His Arg Met Arg Thr Glu Thr Lys 
                245                 250                 255     


Ala Ala Lys Thr Leu Cys Ile Ile Met Gly Cys Phe Cys Leu Cys Trp 
            260                 265                 270         


Ala Pro Phe Phe Val Thr Asn Ile Val Asp Pro Phe Ile Asp Tyr Thr 
        275                 280                 285             


Val Pro Gly Gln Val Trp Thr Ala Phe Leu Trp Leu Gly Tyr Ile Asn 
    290                 295                 300                 


Ser Gly Leu Asn Pro Phe Leu Tyr Ala Phe Leu Asn Lys Ser Phe Arg 
305                 310                 315                 320 


Arg Ala Phe Leu Ile Ile Leu Cys Cys Asp Asp Glu Arg Tyr Arg Arg 
                325                 330                 335     


Pro Ser Ile Leu Gly Gln Thr Val Pro Cys Ser Thr Thr Thr Ile Asn 
            340                 345                 350         


Gly Ser Thr His Val Leu Arg Phe 
        355                 360 


<210>  851
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  851

Met Asp Lys Leu Asp Ala Asn Val Ser Ser Glu Glu Gly Phe Gly Ser 
1               5                   10                  15      


Val Glu Lys Val Val Leu Leu Thr Phe Leu Ser Thr Val Ile Leu Met 
            20                  25                  30          


Ala Ile Leu Gly Asn Leu Leu Val Met Val Ala Val Cys Trp Asp Arg 
        35                  40                  45              


Gln Leu Arg Lys Ile Lys Thr Asn Tyr Phe Ile Val Ser Leu Ala Phe 
    50                  55                  60                  


Ala Asp Leu Leu Val Ser Val Leu Val Met Pro Phe Gly Ala Ile Glu 
65                  70                  75                  80  


Leu Val Gln Asp Ile Trp Ile Tyr Gly Glu Val Phe Cys Leu Val Arg 
                85                  90                  95      


Thr Ser Leu Asp Val Leu Leu Thr Thr Ala Ser Ile Phe His Leu Cys 
            100                 105                 110         


Cys Ile Ser Leu Asp Arg Tyr Tyr Ala Ile Cys Cys Gln Pro Leu Val 
        115                 120                 125             


Tyr Arg Asn Lys Met Thr Pro Leu Arg Ile Ala Leu Met Leu Gly Gly 
    130                 135                 140                 


Cys Trp Val Ile Pro Thr Phe Ile Ser Phe Leu Pro Ile Met Gln Gly 
145                 150                 155                 160 


Trp Asn Asn Ile Gly Ile Ile Asp Leu Ile Glu Lys Arg Lys Phe Asn 
                165                 170                 175     


Gln Asn Ser Asn Ser Thr Tyr Cys Val Phe Met Val Asn Lys Pro Tyr 
            180                 185                 190         


Ala Ile Thr Cys Ser Val Val Ala Phe Tyr Ile Pro Phe Leu Leu Met 
        195                 200                 205             


Val Leu Ala Tyr Tyr Arg Ile Tyr Val Thr Ala Lys Glu His Ala His 
    210                 215                 220                 


Gln Ile Gln Met Leu Gln Arg Ala Gly Ala Ser Ser Glu Ser Arg Pro 
225                 230                 235                 240 


Gln Ser Ala Asp Gln His Ser Thr His Arg Met Arg Thr Glu Thr Lys 
                245                 250                 255     


Ala Ala Lys Thr Leu Cys Ile Ile Met Gly Cys Phe Cys Leu Cys Trp 
            260                 265                 270         


Ala Pro Phe Phe Val Thr Asn Ile Val Asp Pro Phe Ile Asp Tyr Thr 
        275                 280                 285             


Val Pro Gly Gln Val Trp Thr Ala Phe Leu Trp Leu Gly Tyr Ile Asn 
    290                 295                 300                 


Ser Gly Leu Asn Pro Phe Leu Tyr Ala Phe Leu Asn Lys Ser Phe Arg 
305                 310                 315                 320 


Arg Ala Phe Leu Ile Ile Leu Cys Cys Asp Asp Glu Arg Tyr Arg Arg 
                325                 330                 335     


Pro Ser Ile Leu Gly Gln Thr Val Pro Cys Ser Thr Thr Thr Ile Asn 
            340                 345                 350         


Gly Ser Thr His Val Leu Arg Thr Asp Phe Leu Phe Asp Arg Asp Ile 
        355                 360                 365             


Leu Ala Arg Tyr Trp Thr Lys Pro Ala Arg Ala Gly Pro Phe Ser Gly 
    370                 375                 380                 


Thr Leu Ser Ile Arg Cys Leu Thr Ala Arg Lys Pro Val Leu Gly Asp 
385                 390                 395                 400 


Ala Val Glu Cys Gly Gly Gln Trp Glu Ser Gln Cys His Pro Pro Ala 
                405                 410                 415     


Thr Ser Pro Leu Val Ala Ala Gln Pro Ser Asp Thr 
            420                 425             


<210>  852
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  852

Met Asp Lys Leu Asp Ala Asn Val Ser Ser Glu Glu Gly Phe Gly Ser 
1               5                   10                  15      


Val Glu Lys Val Val Leu Leu Thr Phe Leu Ser Thr Val Ile Leu Met 
            20                  25                  30          


Ala Ile Leu Gly Asn Leu Leu Val Met Val Ala Val Cys Trp Asp Arg 
        35                  40                  45              


Gln Leu Arg Lys Ile Lys Thr Asn Tyr Phe Ile Val Ser Leu Ala Phe 
    50                  55                  60                  


Ala Asp Leu Leu Val Ser Val Leu Val Met Pro Phe Gly Ala Ile Glu 
65                  70                  75                  80  


Leu Val Gln Asp Ile Trp Ile Tyr Gly Glu Val Phe Cys Leu Val Arg 
                85                  90                  95      


Thr Ser Leu Asp Val Leu Leu Thr Thr Ala Ser Ile Phe His Leu Cys 
            100                 105                 110         


Cys Ile Ser Leu Asp Arg Tyr Tyr Ala Ile Cys Cys Gln Pro Leu Val 
        115                 120                 125             


Tyr Arg Asn Lys Met Thr Pro Leu Arg Ile Ala Leu Met Leu Gly Gly 
    130                 135                 140                 


Cys Trp Val Ile Pro Thr Phe Ile Ser Phe Leu Pro Ile Met Gln Gly 
145                 150                 155                 160 


Trp Asn Asn Ile Gly Ile Ile Asp Leu Ile Glu Lys Arg Lys Phe Asn 
                165                 170                 175     


Gln Asn Ser Asn Ser Thr Tyr Cys Val Phe Met Val Asn Lys Pro Tyr 
            180                 185                 190         


Ala Ile Thr Cys Ser Val Val Ala Phe Tyr Ile Pro Phe Leu Leu Met 
        195                 200                 205             


Val Leu Ala Tyr Tyr Arg Ile Tyr Val Thr Ala Lys Glu His Ala His 
    210                 215                 220                 


Gln Ile Gln Met Leu Gln Arg Ala Gly Ala Ser Ser Glu Ser Arg Pro 
225                 230                 235                 240 


Gln Ser Ala Asp Gln His Ser Thr His Arg Met Arg Thr Glu Thr Lys 
                245                 250                 255     


Ala Ala Lys Thr Leu Cys Ile Ile Met Gly Cys Phe Cys Leu Cys Trp 
            260                 265                 270         


Ala Pro Phe Phe Val Thr Asn Ile Val Asp Pro Phe Ile Asp Tyr Thr 
        275                 280                 285             


Val Pro Gly Gln Val Trp Thr Ala Phe Leu Trp Leu Gly Tyr Ile Asn 
    290                 295                 300                 


Ser Gly Leu Asn Pro Phe Leu Tyr Ala Phe Leu Asn Lys Ser Phe Arg 
305                 310                 315                 320 


Arg Ala Phe Leu Ile Ile Leu Cys Cys Asp Asp Glu Arg Tyr Arg Arg 
                325                 330                 335     


Pro Ser Ile Leu Gly Gln Thr Val Pro Cys Ser Thr Thr Thr Ile Asn 
            340                 345                 350         


Gly Ser Thr His Val Leu Arg Asp Ala Val Glu Cys Gly Gly Gln Trp 
        355                 360                 365             


Glu Ser Gln Cys His Pro Pro Ala Thr Ser Pro Leu Val Ala Ala Gln 
    370                 375                 380                 


Pro Ser Asp Thr 
385             


<210>  853
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  853

Met Asn Pro Phe His Ala Ser Cys Trp Asn Thr Ser Ala Glu Leu Leu 
1               5                   10                  15      


Asn Lys Ser Trp Asn Lys Glu Phe Ala Tyr Gln Thr Ala Ser Val Val 
            20                  25                  30          


Asp Thr Val Ile Leu Pro Ser Met Ile Gly Ile Ile Cys Ser Thr Gly 
        35                  40                  45              


Leu Val Gly Asn Ile Leu Ile Val Phe Thr Ile Ile Arg Ser Arg Lys 
    50                  55                  60                  


Lys Thr Val Pro Asp Ile Tyr Ile Cys Asn Leu Ala Val Ala Asp Leu 
65                  70                  75                  80  


Val His Ile Val Gly Met Pro Phe Leu Ile His Gln Trp Ala Arg Gly 
                85                  90                  95      


Gly Glu Trp Val Phe Gly Gly Pro Leu Cys Thr Ile Ile Thr Ser Leu 
            100                 105                 110         


Asp Thr Cys Asn Gln Phe Ala Cys Ser Ala Ile Met Thr Val Met Ser 
        115                 120                 125             


Val Asp Arg Tyr Phe Ala Leu Val Gln Pro Phe Arg Leu Thr Arg Trp 
    130                 135                 140                 


Arg Thr Arg Tyr Lys Thr Ile Arg Ile Asn Leu Gly Leu Trp Ala Ala 
145                 150                 155                 160 


Ser Phe Ile Leu Ala Leu Pro Val Trp Val Tyr Ser Lys Val Ile Lys 
                165                 170                 175     


Phe Lys Asp Gly Val Glu Ser Cys Ala Phe Asp Leu Thr Ser Pro Asp 
            180                 185                 190         


Asp Val Leu Trp Tyr Thr Leu Tyr Leu Thr Ile Thr Thr Phe Phe Phe 
        195                 200                 205             


Pro Leu Pro Leu Ile Leu Val Cys Tyr Ile Leu Ile Leu Cys Tyr Thr 
    210                 215                 220                 


Trp Glu Met Tyr Gln Gln Asn Lys Asp Ala Arg Cys Cys Asn Pro Ser 
225                 230                 235                 240 


Val Pro Lys Gln Arg Val Met Lys Leu Thr Lys Met Val Leu Val Leu 
                245                 250                 255     


Val Val Val Phe Ile Leu Ser Ala Ala Pro Tyr His Val Ile Gln Leu 
            260                 265                 270         


Val Asn Leu Gln Met Glu Gln Pro Thr Leu Ala Phe Tyr Val Gly Tyr 
        275                 280                 285             


Tyr Leu Ser Ile Cys Leu Ser Tyr Ala Ser Ser Ser Ile Asn Pro Phe 
    290                 295                 300                 


Leu Tyr Ile Leu Leu Ser Gly Asn Phe Gln Lys Arg Leu Pro Gln Ile 
305                 310                 315                 320 


Gln Arg Arg Ala Thr Glu Lys Glu Ile Asn Asn Met Gly Asn Thr Leu 
                325                 330                 335     


Lys Ser His Phe 
            340 


<210>  854
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  854

Met Asp Asn Arg Phe Ala Thr Ala Phe Val Ile Ala Cys Val Leu Ser 
1               5                   10                  15      


Leu Ile Ser Thr Ile Tyr Met Ala Ala Ser Ile Gly Thr Asp Phe Trp 
            20                  25                  30          


Tyr Glu Tyr Arg Ser Pro Val Gln Glu Asn Ser Ser Asp Leu Asn Lys 
        35                  40                  45              


Ser Ile Trp Asp Glu Phe Ile Ser Asp Glu Ala Asp Glu Lys Thr Tyr 
    50                  55                  60                  


Asn Asp Ala Leu Phe Arg Tyr Asn Gly Thr Val Gly Leu Trp Arg Arg 
65                  70                  75                  80  


Cys Ile Thr Ile Pro Lys Asn Met His Trp Tyr Ser Pro Pro Glu Arg 
                85                  90                  95      


Thr Glu Ser Phe Asp Val Val Thr Lys Cys Val Ser Phe Thr Leu Thr 
            100                 105                 110         


Glu Gln Phe Met Glu Lys Phe Val Asp Pro Gly Asn His Asn Ser Gly 
        115                 120                 125             


Ile Asp Leu Leu Arg Thr Tyr Leu Trp Arg Cys Gln Phe Leu Leu Pro 
    130                 135                 140                 


Phe Val Ser Leu Gly Leu Met Cys Phe Gly Ala Leu Ile Gly Leu Cys 
145                 150                 155                 160 


Ala Cys Ile Cys Arg Ser Leu Tyr Pro Thr Ile Ala Thr Gly Ile Leu 
                165                 170                 175     


His Leu Leu Ala Gly Leu Cys Thr Leu Gly Ser Val Ser Cys Tyr Val 
            180                 185                 190         


Ala Gly Ile Glu Leu Leu His Gln Lys Leu Glu Leu Pro Asp Asn Val 
        195                 200                 205             


Ser Gly Glu Phe Gly Trp Ser Phe Cys Leu Ala Cys Val Ser Ala Pro 
    210                 215                 220                 


Leu Gln Phe Met Ala Ser Ala Leu Phe Ile Trp Ala Ala His Thr Asn 
225                 230                 235                 240 


Arg Lys Glu Tyr Thr Leu Met Lys Ala Tyr Arg Val Ala 
                245                 250             


<210>  855
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  855

Met Gly Gly Asp Arg Leu Glu Asn Lys Thr Ser Val Ser Val Ala Ser 
1               5                   10                  15      


Trp Ser Ser Leu Asn Ala Arg Met Asp Asn Arg Phe Ala Thr Ala Phe 
            20                  25                  30          


Val Ile Ala Cys Val Leu Ser Leu Ile Ser Thr Ile Tyr Met Ala Ala 
        35                  40                  45              


Ser Ile Gly Thr Asp Phe Trp Tyr Glu Tyr Arg Ser Pro Val Gln Glu 
    50                  55                  60                  


Asn Ser Ser Asp Leu Asn Lys Ser Ile Trp Asp Glu Phe Ile Ser Asp 
65                  70                  75                  80  


Glu Ala Asp Glu Lys Thr Tyr Asn Asp Ala Leu Phe Arg Tyr Asn Gly 
                85                  90                  95      


Thr Val Gly Leu Trp Arg Arg Cys Ile Thr Ile Pro Lys Asn Met His 
            100                 105                 110         


Trp Tyr Ser Pro Pro Glu Arg Thr Glu Ser Phe Asp Val Val Thr Lys 
        115                 120                 125             


Cys Val Ser Phe Thr Leu Thr Glu Gln Phe Met Glu Lys Phe Val Asp 
    130                 135                 140                 


Pro Gly Asn His Asn Ser Gly Ile Asp Leu Leu Arg Thr Tyr Leu Trp 
145                 150                 155                 160 


Arg Cys Gln Phe Leu Leu Pro Phe Val Ser Leu Gly Leu Met Cys Phe 
                165                 170                 175     


Gly Ala Leu Ile Gly Leu Cys Ala Cys Ile Cys Arg Ser Leu Tyr Pro 
            180                 185                 190         


Thr Ile Ala Thr Gly Ile Leu His Leu Leu Ala Gly Leu Cys Thr Leu 
        195                 200                 205             


Gly Ser Val Ser Cys Tyr Val Ala Gly Ile Glu Leu Leu His Gln Lys 
    210                 215                 220                 


Leu Glu Leu Pro Asp Asn Val Ser Gly Glu Phe Gly Trp Ser Phe Cys 
225                 230                 235                 240 


Leu Ala Cys Val Ser Ala Pro Leu Gln Phe Met Ala Ser Ala Leu Phe 
                245                 250                 255     


Ile Trp Ala Ala His Thr Asn Arg Lys Glu Tyr Thr Leu Met Lys Ala 
            260                 265                 270         


Tyr Arg Val Ala 
        275     


<210>  856
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  856

Met Asp Asn Arg Phe Ala Thr Ala Phe Val Ile Ala Cys Val Leu Ser 
1               5                   10                  15      


Leu Ile Ser Thr Ile Tyr Met Ala Ala Ser Ile Gly Thr Asp Phe Trp 
            20                  25                  30          


Tyr Glu Tyr Arg Ser Pro Val Gln Glu Asn Ser Ser Asp Leu Asn Lys 
        35                  40                  45              


Ser Ile Trp Asp Glu Phe Ile Ser Asp Glu Ala Asp Glu Lys Thr Tyr 
    50                  55                  60                  


Asn Asp Ala Leu Phe Arg Tyr Asn Gly Thr Val Gly Leu Trp Arg Arg 
65                  70                  75                  80  


Cys Ile Thr Ile Pro Lys Asn Met His Trp Tyr Ser Pro Pro Glu Arg 
                85                  90                  95      


Thr Glu Ser Phe Asp Val Val Thr Lys Cys Val Ser Phe Thr Leu Thr 
            100                 105                 110         


Glu Gln Phe Met Glu Lys Phe Val Asp Pro Gly Asn His Asn Ser Gly 
        115                 120                 125             


Ile Asp Leu Leu Arg Thr Tyr Leu Trp Arg Cys Gln Phe Leu Leu Pro 
    130                 135                 140                 


Phe Val Ser Leu Gly Leu Met Cys Phe Gly Ala Leu Ile Gly Leu Cys 
145                 150                 155                 160 


Ala Cys Ile Cys Arg Ser Leu Tyr Pro Thr Ile Ala Thr Gly Ile Leu 
                165                 170                 175     


His Leu Leu Ala Gly Leu Cys Thr Leu Gly Ser Val Ser Cys Tyr Val 
            180                 185                 190         


Ala Gly Ile Glu Leu Leu His Gln Lys Leu Glu Leu Pro Asp Asn Val 
        195                 200                 205             


Ser Gly Glu Phe Gly Trp Ser Phe Cys Leu Ala Cys Val Ser Ala Pro 
    210                 215                 220                 


Leu Gln Phe Met Ala Ser Ala Leu Phe Ile Trp Ala Ala His Thr Asn 
225                 230                 235                 240 


Arg Lys Glu Tyr Thr Leu Met Lys Ala Tyr Arg Val Ala 
                245                 250             


<210>  857
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  857

Met Glu Leu Pro Ala Val Asn Leu Lys Val Ile Leu Leu Gly His Trp 
1               5                   10                  15      


Leu Leu Thr Thr Trp Gly Cys Ile Val Phe Ser Gly Ser Tyr Ala Trp 
            20                  25                  30          


Ala Asn Phe Thr Ile Leu Ala Leu Gly Val Trp Ala Val Ala Gln Arg 
        35                  40                  45              


Asp Ser Ile Asp Ala Ile Ser Met Phe Leu Gly Gly Leu Leu Ala Thr 
    50                  55                  60                  


Ile Phe Leu Asp Ile Val His Ile Ser Ile Phe Tyr Pro Arg Val Ser 
65                  70                  75                  80  


Leu Thr Asp Thr Gly Arg Phe Gly Val Gly Met Ala Ile Leu Ser Leu 
                85                  90                  95      


Leu Leu Lys Pro Leu Ser Cys Cys Phe Val Tyr His Met Tyr Arg Glu 
            100                 105                 110         


Arg Gly Gly Phe Leu Gly Ser Ser Gln Asp Arg Ser Ala Tyr Gln Thr 
        115                 120                 125             


Ile Asp Ser Ala Glu Ala Pro Ala Asp Pro Phe Ala Val Pro Glu Gly 
    130                 135                 140                 


Arg Ser Gln Asp Ala Arg Gly Tyr 
145                 150         


<210>  858
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  858

Met Glu Leu Pro Ala Val Asn Leu Lys Gly Leu His Cys Ile Leu Arg 
1               5                   10                  15      


Leu Leu Cys Leu Gly Gln Leu His His Pro Gly Leu Gly Arg Val Gly 
            20                  25                  30          


Cys Gly Ser Ala Gly Leu His Arg Arg His Lys His Val Ser Gly Trp 
        35                  40                  45              


Leu Ala Gly His His Leu Pro Gly His Arg Ala His Gln His Leu Leu 
    50                  55                  60                  


Pro Ala Gly Gln Pro His Gly His Gly Pro Leu Trp Arg Gly His Gly 
65                  70                  75                  80  


His Pro Gln Leu Ala Ala Gln Ala Ala Leu Leu Leu Leu Arg Leu Pro 
                85                  90                  95      


His Val Pro Gly Ala Arg Gly Phe Pro Trp Val Phe Ser Gly Pro 
            100                 105                 110     


<210>  859
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  859

Met Glu Leu Pro Ala Val Asn Leu Lys Val Ile Leu Leu Gly His Trp 
1               5                   10                  15      


Leu Leu Thr Thr Cys Phe Trp Arg His Phe Ser Ala Lys Pro Arg Leu 
            20                  25                  30          


Glu Thr Ile Glu Leu Thr Cys Ala Leu Cys Lys Leu Arg Ser Ala Ala 
        35                  40                  45              


His Arg Ala Thr Ala Gly Leu His Cys Ile Leu Arg Leu Leu Cys Leu 
    50                  55                  60                  


Gly Gln Leu His His Pro Gly Leu Gly Arg Val Gly Cys Gly Ser Ala 
65                  70                  75                  80  


Gly Leu His Arg Arg His Lys His Val Ser Gly Trp Leu Ala Gly His 
                85                  90                  95      


His Leu Pro Gly His Arg Ala His Gln His Leu Leu Pro Ala Gly Gln 
            100                 105                 110         


Pro His Gly His Gly Pro Leu Trp Arg Gly His Gly His Pro Gln Leu 
        115                 120                 125             


Ala Ala Gln Ala Ala Leu Leu Leu Leu Arg Leu Pro His Val Pro Gly 
    130                 135                 140                 


Ala Arg Gly Phe Pro Trp Val Phe Ser Gly Pro 
145                 150                 155 


<210>  860
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  860

Met Glu Leu Pro Ala Val Asn Leu Lys Val Ile Leu Leu Gly His Trp 
1               5                   10                  15      


Leu Leu Thr Thr Cys Phe Trp Arg His Phe Ser Ala Lys Pro Arg Leu 
            20                  25                  30          


Glu Thr Ile Glu Leu Thr Cys Ala Leu Cys Lys Leu Arg Ser Ala Ala 
        35                  40                  45              


His Arg Ala Thr Ala Gly Leu His Cys Ile Leu Arg Leu Leu Cys Leu 
    50                  55                  60                  


Gly Gln Leu His His Pro Gly Leu Gly Arg Val Gly Cys Gly Ser Ala 
65                  70                  75                  80  


Gly Leu His Arg Arg His Lys His Val Ser Gly Trp Leu Ala Gly His 
                85                  90                  95      


His Leu Pro Gly His Arg Ala His Gln His Leu Leu Pro Ala Gly Gln 
            100                 105                 110         


Pro His Gly His Gly Pro Leu Trp Arg Gly His Gly His Pro Gln Leu 
        115                 120                 125             


Ala Ala Gln Ala Ala Leu Leu Leu Leu Arg Leu Pro His Val Pro Gly 
    130                 135                 140                 


Ala Arg Gly 
145         


<210>  861
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  861

Met Asp Asn Arg Phe Ala Thr Ala Phe Val Ile Ala Cys Val Leu Ser 
1               5                   10                  15      


Leu Ile Ser Thr Ile Tyr Met Ala Ala Ser Ile Gly Thr Asp Phe Trp 
            20                  25                  30          


Tyr Glu Tyr Arg Ser Pro Val Gln Glu Asn Ser Ser Asp Leu Asn Lys 
        35                  40                  45              


Ser Ile Trp Asp Glu Phe Ile Ser Asp Glu Ala Asp Glu Lys Thr Tyr 
    50                  55                  60                  


Asn Asp Ala Leu Phe Arg Tyr Asn Gly Thr Val Gly Leu Trp Arg Arg 
65                  70                  75                  80  


Cys Ile Thr Ile Pro Lys Asn Met His Trp Tyr Ser Pro Pro Glu Arg 
                85                  90                  95      


Thr Glu Ser Phe Asp Val Val Thr Lys Cys Val Ser Phe Thr Leu Thr 
            100                 105                 110         


Glu Gln Phe Met Glu Lys Phe Val Asp Pro Gly Asn His Asn Ser Gly 
        115                 120                 125             


Ile Asp Leu Leu Arg Thr Tyr Leu Trp Arg Cys Gln Phe Leu Leu Pro 
    130                 135                 140                 


Phe Val Ser Leu Gly Leu Met Cys Phe Gly Ala Leu Ile Gly Leu Cys 
145                 150                 155                 160 


Ala Cys Ile Cys Arg Ser Leu Tyr Pro Thr Ile Ala Thr Gly Ile Leu 
                165                 170                 175     


His Leu Leu Ala Gly Leu Cys Thr Leu Gly Ser Val Ser Cys Tyr Val 
            180                 185                 190         


Ala Gly Ile Glu Leu Leu His Gln Lys Leu Glu Leu Pro Asp Asn Val 
        195                 200                 205             


Ser Gly Glu Phe Gly Trp Ser Phe Cys Leu Ala Cys Val Ser Ala Pro 
    210                 215                 220                 


Leu Gln Phe Met Ala Ser Ala Leu Phe Ile Trp Ala Ala His Thr Asn 
225                 230                 235                 240 


Arg Lys Glu Tyr Thr Leu Met Lys Ala Tyr Arg Val Ala 
                245                 250             


<210>  862
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  862

Met Gly Glu Ser Phe Asp Val Val Thr Lys Cys Val Ser Phe Thr Leu 
1               5                   10                  15      


Thr Glu Gln Phe Met Glu Lys Phe Val Asp Pro Gly Asn His Asn Ser 
            20                  25                  30          


Gly Ile Asp Leu Leu Arg Thr Tyr Leu Trp Arg Cys Gln Phe Leu Leu 
        35                  40                  45              


Pro Phe Val Ser Leu Gly Leu Met Cys Phe Gly Ala Leu Ile Gly Leu 
    50                  55                  60                  


Cys Ala Cys Ile Cys Arg Ser Leu Tyr Pro Thr Ile Ala Thr Gly Ile 
65                  70                  75                  80  


Leu His Leu Leu Ala Gly Leu Cys Thr Leu Gly Ser Val Ser Cys Tyr 
                85                  90                  95      


Val Ala Gly Ile Glu Leu Leu His Gln Lys Leu Glu Leu Pro Asp Asn 
            100                 105                 110         


Val Ser Gly Glu Phe Gly Trp Ser Phe Cys Leu Ala Cys Val Ser Ala 
        115                 120                 125             


Pro Leu Gln Phe Met Ala Ser Ala Leu Phe Ile Trp Ala Ala His Thr 
    130                 135                 140                 


Asn Arg Lys Glu Tyr Thr Leu Met Lys Ala Tyr Arg Val Ala 
145                 150                 155             


<210>  863
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  863

Met His Gln Lys Leu Leu Lys Ser Ala His Tyr Ile Glu Leu Gly Ser 
1               5                   10                  15      


Tyr Gln Tyr Trp Pro Val Leu Val Pro Arg Gly Ile Arg Leu Tyr Thr 
            20                  25                  30          


Tyr Glu Gln Ile Pro Gly Ser Leu Lys Asp Asn Pro Tyr Ile Thr Asp 
        35                  40                  45              


Gly Tyr Arg Ala Tyr Leu Pro Ser Arg Leu Cys Ile Lys Ser Leu Phe 
    50                  55                  60                  


Ile Leu Ser Asn Glu Thr Val Asn Ile Trp Ser His Leu Leu Gly Phe 
65                  70                  75                  80  


Phe Leu Phe Phe Thr Leu Gly Ile Tyr Asp Met Thr Ser Val Leu Pro 
                85                  90                  95      


Ser Ala Ser Ala Ser Arg Glu Asp Phe Val Ile Cys Ser Ile Cys Leu 
            100                 105                 110         


Phe Cys Phe Gln Val Cys Met Leu Cys Ser Val Gly Tyr His Leu Phe 
        115                 120                 125             


Ser Cys His Arg Ser Glu Lys Thr Cys Arg Arg Trp Met Ala Leu Asp 
    130                 135                 140                 


Tyr Ala Gly Ile Ser Ile Gly Ile Leu Gly Cys Tyr Val Ser Gly Val 
145                 150                 155                 160 


Phe Tyr Ala Phe Tyr Cys Asn Asn Tyr Trp Arg Gln Val Tyr Leu Ile 
                165                 170                 175     


Thr Val Leu Ala Met Ile Leu Ala Val Phe Phe Ala Gln Ile His Pro 
            180                 185                 190         


Asn Tyr Leu Thr Gln Gln Trp Gln Arg Leu Arg Ser Ile Ile Phe Cys 
        195                 200                 205             


Ser Val Ser Gly Tyr Gly Val Ile Pro Thr Leu His Trp Val Trp Leu 
    210                 215                 220                 


Asn Gly Gly Ile Gly Ala Pro Ile Val Gln Asp Phe Ala Pro Arg Val 
225                 230                 235                 240 


Ile Val Met Tyr Met Ile Ala Leu Leu Ala Phe Leu Phe Tyr Ile Ser 
                245                 250                 255     


Lys Val Pro Glu Arg Tyr Phe Pro Gly Gln Leu Asn Tyr Leu Gly Ser 
            260                 265                 270         


Ser His Gln Ile Trp His Ile Leu Ala Val Val Met Leu Tyr Trp Trp 
        275                 280                 285             


His Gln Ser Thr Val Tyr Val Met Gln Tyr Arg His Ser Lys Pro Cys 
    290                 295                 300                 


Pro Asp Tyr Val Ser His Leu 
305                 310     


<210>  864
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  864

Met Gly Tyr Cys Ser Gly Arg Cys Thr Leu Ile Phe Ile Cys Gly Met 
1               5                   10                  15      


Gln Leu Val Cys Val Leu Glu Arg Gln Ile Phe Asp Phe Leu Gly Tyr 
            20                  25                  30          


Gln Trp Ala Pro Ile Leu Ala Asn Phe Val His Ile Ile Ile Val Ile 
        35                  40                  45              


Leu Gly Leu Phe Gly Thr Ile Gln Tyr Arg Pro Arg Tyr Ile Thr Gly 
    50                  55                  60                  


Tyr Ala Val Trp Leu Val Leu Trp Val Thr Trp Asn Val Phe Val Ile 
65                  70                  75                  80  


Cys Phe Tyr Leu Glu Ala Gly Asp Leu Ser Lys Glu Thr Asp Leu Ile 
                85                  90                  95      


Leu Thr Phe Asn Ile Ser Met His Arg Ser Trp Trp Met Glu Asn Gly 
            100                 105                 110         


Pro Gly Cys Thr Val Thr Ser Val Thr Pro Ala Pro Asp Trp Ala Pro 
        115                 120                 125             


Glu Asp His Arg Tyr Ile Thr Val Ser Gly Cys Leu Leu Glu Tyr Gln 
    130                 135                 140                 


Tyr Ile Glu Val Ala His Ser Ser Leu Gln Ile Val Leu Ala Leu Ala 
145                 150                 155                 160 


Gly Phe Ile Tyr Ala Cys Tyr Val Val Lys Cys Ile Thr Glu Glu Glu 
                165                 170                 175     


Asp Ser Phe Asp Phe Ile Gly Gly Phe Asp Ser Tyr Gly Tyr Gln Gly 
            180                 185                 190         


Pro Gln Lys Thr Ser His Leu Gln Leu Gln Pro Met Tyr Met Ser Lys 
        195                 200                 205             


<210>  865
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  865

Met Ser Arg Gly Leu Gln Leu Leu Leu Leu Ser Cys Ala Tyr Ser Leu 
1               5                   10                  15      


Ala Pro Ala Thr Pro Glu Val Lys Val Ala Cys Ser Glu Asp Val Asp 
            20                  25                  30          


Leu Pro Cys Thr Ala Pro Trp Asp Pro Gln Val Pro Tyr Thr Val Ser 
        35                  40                  45              


Trp Val Lys Leu Leu Glu Gly Gly Glu Glu Arg Met Glu Thr Pro Gln 
    50                  55                  60                  


Glu Asp His Leu Arg Gly Gln His Tyr His Gln Lys Gly Gln Asn Gly 
65                  70                  75                  80  


Ser Phe Asp Ala Pro Asn Glu Arg Pro Tyr Ser Leu Lys Ile Arg Asn 
                85                  90                  95      


Thr Thr Ser Cys Asn Ser Gly Thr Tyr Arg Cys Thr Leu Gln Asp Pro 
            100                 105                 110         


Asp Gly Gln Arg Asn Leu Ser Gly Lys Val Ile Leu Arg Val Thr Gly 
        115                 120                 125             


Cys Pro Ala Gln Arg Lys Glu Glu Thr Phe Lys Lys Tyr Arg Ala Glu 
    130                 135                 140                 


Ile Val Leu Leu Leu Ala Leu Val Ile Phe Tyr Leu Thr Leu Ile Ile 
145                 150                 155                 160 


Phe Thr Cys Phe Ala Arg Leu Gln Ser Ile Phe Pro Asp Phe Ser Lys 
                165                 170                 175     


Ala Gly Met Glu Arg Ala Phe Leu Pro Val Thr Ser Pro Asn Lys His 
            180                 185                 190         


Leu Gly Leu Val Thr Pro His Lys Thr Glu Leu Val 
        195                 200                 


<210>  866
<211>  1159
<212>  PRT
<213>  Homo sapiens

<400>  866

Met Tyr Leu Ser Ile Cys Cys Cys Phe Leu Leu Trp Ala Pro Ala Leu 
1               5                   10                  15      


Thr Leu Lys Asn Leu Asn Tyr Ser Val Pro Glu Glu Gln Gly Ala Gly 
            20                  25                  30          


Thr Val Ile Gly Asn Ile Gly Arg Asp Ala Arg Leu Gln Pro Gly Leu 
        35                  40                  45              


Pro Pro Ala Glu Arg Gly Gly Gly Gly Arg Ser Lys Ser Gly Ser Tyr 
    50                  55                  60                  


Arg Val Leu Glu Asn Ser Ala Pro His Leu Leu Asp Val Asp Ala Asp 
65                  70                  75                  80  


Ser Gly Leu Leu Tyr Thr Lys Gln Arg Ile Asp Arg Glu Ser Leu Cys 
                85                  90                  95      


Arg His Asn Ala Lys Cys Gln Leu Ser Leu Glu Val Phe Ala Asn Asp 
            100                 105                 110         


Lys Glu Ile Cys Met Ile Lys Val Glu Ile Gln Asp Ile Asn Asp Asn 
        115                 120                 125             


Ala Pro Ser Phe Ser Ser Asp Gln Ile Glu Met Asp Ile Ser Glu Asn 
    130                 135                 140                 


Ala Ala Pro Gly Thr Arg Phe Pro Leu Thr Ser Ala His Asp Pro Asp 
145                 150                 155                 160 


Ala Gly Glu Asn Gly Leu Arg Thr Tyr Leu Leu Thr Arg Asp Asp His 
                165                 170                 175     


Gly Leu Phe Gly Leu Asp Val Lys Ser Arg Gly Asp Gly Thr Lys Phe 
            180                 185                 190         


Pro Glu Leu Val Ile Gln Lys Ala Leu Asp Arg Glu Gln Gln Asn His 
        195                 200                 205             


His Thr Leu Val Leu Thr Ala Leu Asp Gly Gly Glu Pro Pro Arg Ser 
    210                 215                 220                 


Ala Thr Val Gln Ile Asn Val Lys Val Ile Asp Ser Asn Asp Asn Ser 
225                 230                 235                 240 


Pro Val Phe Glu Ala Pro Ser Tyr Leu Val Glu Leu Pro Glu Asn Ala 
                245                 250                 255     


Pro Leu Gly Thr Val Val Ile Asp Leu Asn Ala Thr Asp Ala Asp Glu 
            260                 265                 270         


Gly Pro Asn Gly Glu Val Leu Tyr Ser Phe Ser Ser Tyr Val Pro Asp 
        275                 280                 285             


Arg Val Arg Glu Leu Phe Ser Ile Asp Pro Lys Thr Gly Leu Ile Arg 
    290                 295                 300                 


Val Lys Gly Asn Leu Asp Tyr Glu Glu Asn Gly Met Leu Glu Ile Asp 
305                 310                 315                 320 


Val Gln Ala Arg Asp Leu Gly Pro Asn Pro Ile Pro Ala His Cys Lys 
                325                 330                 335     


Val Thr Val Lys Leu Ile Asp Arg Asn Asp Asn Ala Pro Ser Ile Gly 
            340                 345                 350         


Phe Val Ser Val Arg Gln Gly Ala Leu Ser Glu Ala Ala Pro Pro Gly 
        355                 360                 365             


Thr Val Ile Ala Leu Val Arg Val Thr Asp Arg Asp Ser Gly Lys Asn 
    370                 375                 380                 


Gly Gln Leu Gln Cys Arg Val Leu Gly Gly Gly Gly Thr Gly Gly Gly 
385                 390                 395                 400 


Gly Gly Leu Gly Gly Pro Gly Gly Ser Val Pro Phe Lys Leu Glu Glu 
                405                 410                 415     


Asn Tyr Asp Asn Phe Tyr Thr Val Val Thr Asp Arg Pro Leu Asp Arg 
            420                 425                 430         


Glu Thr Gln Asp Glu Tyr Asn Val Thr Ile Val Ala Arg Asp Gly Gly 
        435                 440                 445             


Ser Pro Pro Leu Asn Ser Thr Lys Ser Phe Ala Ile Lys Ile Leu Asp 
    450                 455                 460                 


Glu Asn Asp Asn Pro Pro Arg Phe Thr Lys Gly Leu Tyr Val Leu Gln 
465                 470                 475                 480 


Val His Glu Asn Asn Ile Pro Gly Glu Tyr Leu Gly Ser Val Leu Ala 
                485                 490                 495     


Gln Asp Pro Asp Leu Gly Gln Asn Gly Thr Val Ser Tyr Ser Ile Leu 
            500                 505                 510         


Pro Ser His Ile Gly Asp Val Ser Ile Tyr Thr Tyr Val Ser Val Asn 
        515                 520                 525             


Pro Thr Asn Gly Ala Ile Tyr Ala Leu Arg Ser Phe Asn Phe Glu Gln 
    530                 535                 540                 


Thr Lys Ala Phe Glu Phe Lys Val Leu Ala Lys Asp Ser Gly Ala Pro 
545                 550                 555                 560 


Ala His Leu Glu Ser Asn Ala Thr Val Arg Val Thr Val Leu Asp Val 
                565                 570                 575     


Asn Asp Asn Ala Pro Val Ile Val Leu Pro Thr Leu Gln Asn Asp Thr 
            580                 585                 590         


Ala Glu Leu Gln Val Pro Arg Asn Ala Gly Leu Gly Tyr Leu Val Ser 
        595                 600                 605             


Thr Val Arg Ala Leu Asp Ser Asp Phe Gly Glu Ser Gly Arg Leu Thr 
    610                 615                 620                 


Tyr Glu Ile Val Asp Gly Asn Asp Asp His Leu Phe Glu Ile Asp Pro 
625                 630                 635                 640 


Ser Ser Gly Glu Ile Arg Thr Leu His Pro Phe Trp Glu Asp Val Thr 
                645                 650                 655     


Pro Val Val Glu Leu Val Val Lys Val Thr Asp His Gly Lys Pro Thr 
            660                 665                 670         


Leu Ser Ala Val Ala Lys Leu Ile Ile Arg Ser Val Ser Gly Ser Leu 
        675                 680                 685             


Pro Glu Gly Val Pro Arg Val Asn Gly Glu Gln His His Trp Asp Met 
    690                 695                 700                 


Ser Leu Pro Leu Ile Val Thr Leu Ser Thr Ile Ser Ile Ile Leu Leu 
705                 710                 715                 720 


Ala Ala Met Ile Thr Ile Ala Val Lys Cys Lys Arg Glu Asn Lys Glu 
                725                 730                 735     


Ile Arg Thr Tyr Asn Cys Arg Ile Ala Glu Tyr Ser His Pro Gln Leu 
            740                 745                 750         


Gly Gly Gly Lys Gly Lys Lys Lys Lys Ile Asn Lys Asn Asp Ile Met 
        755                 760                 765             


Leu Val Gln Ser Glu Val Glu Glu Arg Asn Ala Met Asn Val Met Asn 
    770                 775                 780                 


Val Val Ser Ser Pro Ser Leu Ala Thr Ser Pro Met Tyr Phe Asp Tyr 
785                 790                 795                 800 


Gln Thr Arg Leu Pro Leu Ser Ser Pro Arg Ser Glu Val Met Tyr Leu 
                805                 810                 815     


Lys Pro Ala Ser Asn Asn Leu Thr Val Pro Gln Gly His Ala Gly Cys 
            820                 825                 830         


His Thr Ser Phe Thr Gly Gln Gly Thr Asn Ala Ser Glu Thr Pro Ala 
        835                 840                 845             


Thr Arg Met Ser Ile Ile Gln Thr Asp Asn Phe Pro Ala Glu Pro Asn 
    850                 855                 860                 


Tyr Met Gly Ser Arg Gln Gln Phe Val Gln Ser Ser Ser Thr Phe Lys 
865                 870                 875                 880 


Asp Pro Glu Arg Ala Ser Leu Arg Asp Ser Gly His Gly Asp Ser Asp 
                885                 890                 895     


Gln Ala Asp Ser Asp Gln Asp Thr Asn Lys Gly Ser Cys Cys Asp Met 
            900                 905                 910         


Ser Val Arg Glu Ala Leu Lys Met Lys Thr Thr Ser Thr Lys Ser Gln 
        915                 920                 925             


Pro Leu Glu Gln Glu Pro Glu Glu Cys Val Asn Cys Thr Asp Glu Cys 
    930                 935                 940                 


Arg Val Leu Gly His Ser Asp Arg Cys Trp Met Pro Gln Phe Pro Ala 
945                 950                 955                 960 


Ala Asn Gln Ala Glu Asn Ala Asp Tyr Arg Thr Asn Leu Phe Val Pro 
                965                 970                 975     


Thr Val Glu Ala Asn Val Glu Thr Glu Thr Tyr Glu Thr Val Asn Pro 
            980                 985                 990         


Thr Gly Lys Lys Thr Phe Cys Thr  Phe Gly Lys Asp Lys  Arg Glu His 
        995                 1000                 1005             


Thr Ile  Leu Ile Ala Asn Val  Lys Pro Tyr Leu Lys  Ala Lys Arg 
    1010                 1015                 1020             


Ala Leu  Ser Pro Leu Leu Gln  Glu Val Pro Ser Ala  Ser Ser Ser 
    1025                 1030                 1035             


Pro Thr  Lys Ala Cys Ile Glu  Pro Cys Thr Ser Thr  Lys Gly Ser 
    1040                 1045                 1050             


Leu Asp  Gly Cys Glu Ala Lys  Pro Gly Ala Leu Ala  Glu Ala Ser 
    1055                 1060                 1065             


Ser Gln  Tyr Leu Pro Thr Asp  Ser Gln Tyr Leu Ser  Pro Ser Lys 
    1070                 1075                 1080             


Gln Pro  Arg Asp Pro Pro Phe  Met Ala Ser Asp Gln  Met Ala Arg 
    1085                 1090                 1095             


Val Phe  Ala Asp Val His Ser  Arg Ala Ser Arg Asp  Ser Ser Glu 
    1100                 1105                 1110             


Met Gly  Ala Val Leu Glu Gln  Leu Asp His Pro Asn  Arg Asp Leu 
    1115                 1120                 1125             


Gly Arg  Glu Ser Val Asp Ala  Glu Glu Val Val Arg  Glu Ile Asp 
    1130                 1135                 1140             


Lys Leu  Leu Gln Asp Cys Arg  Gly Asn Asp Pro Val  Ala Val Arg 
    1145                 1150                 1155             


Lys 
    


<210>  867
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  867

Met Ala Ser Ser Gly Ala Gly Asp Pro Leu Asp Ser Lys Arg Gly Glu 
1               5                   10                  15      


Ala Pro Phe Ala Gln Arg Ile Asp Pro Thr Arg Glu Lys Leu Thr Pro 
            20                  25                  30          


Glu Gln Leu His Ser Met Arg Gln Ala Glu Leu Ala Gln Trp Gln Lys 
        35                  40                  45              


Val Leu Pro Arg Arg Arg Thr Arg Asn Ile Val Thr Gly Leu Gly Ile 
    50                  55                  60                  


Gly Ala Leu Val Leu Ala Ile Tyr Gly Tyr Thr Phe Tyr Ser Ile Ser 
65                  70                  75                  80  


Gln Glu Arg Phe Leu Asp Glu Leu Glu Asp Glu Ala Lys Ala Ala Arg 
                85                  90                  95      


Ala Arg Ala Leu Ala Arg Ala Ser Gly Ser 
            100                 105     


<210>  868
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  868

Met Ala Ala Leu Thr Thr Val Val Val Ala Ala Ala Ala Thr Ala Val 
1               5                   10                  15      


Ala Gly Ala Val Ala Gly Ala Gly Ala Ala Thr Gly Thr Gly Val Gly 
            20                  25                  30          


Ala Thr Pro Ala Pro Gln Gln Ser Asp Gly Cys Phe Ser Thr Ser Gly 
        35                  40                  45              


Gly Ile Arg Pro Phe His Leu Gln Asn Trp Lys Gln Lys Val Asn Gln 
    50                  55                  60                  


Thr Lys Lys Ala Glu Phe Val Arg Thr Ala Glu Lys Phe Lys Asn Gln 
65                  70                  75                  80  


Val Ile Asn Met Glu Lys Asp Lys His Ser His Phe Tyr Asn Gln Lys 
                85                  90                  95      


Ser Asp Phe Arg Ile Glu His Ser Met Leu Glu Glu Leu Glu Asn Lys 
            100                 105                 110         


Leu Ile His Ser Arg Lys Thr Glu Arg Ala Lys Ile Gln Gln Gln Leu 
        115                 120                 125             


Ala Lys Ile His Asn Asn Val Lys Lys Leu Gln His Gln Leu Lys Asp 
    130                 135                 140                 


Val Lys Pro Thr Pro Asp Phe Val Glu Lys Leu Arg Glu Met Met Glu 
145                 150                 155                 160 


Glu Ile Glu Asn Ala Ile Asn Thr Phe Lys Glu Glu Gln Arg Leu Ile 
                165                 170                 175     


Tyr Glu Glu Leu Ile Lys Glu Glu Lys Thr Thr Asn Asn Glu Leu Ser 
            180                 185                 190         


Ala Ile Ser Arg Lys Ile Asp Thr Trp Ala Leu Gly Asn Ser Glu Thr 
        195                 200                 205             


Glu Lys Ala Phe Arg Ala Ile Ser Ser Lys Val Pro Val Asp Lys Val 
    210                 215                 220                 


Thr Pro Ser Thr Leu Pro Glu Glu Val Leu Asp Phe Glu Lys Phe Leu 
225                 230                 235                 240 


Gln Gln Thr Gly Gly Arg Gln Gly Ala Trp Asp Asp Tyr Asp His Gln 
                245                 250                 255     


Asn Phe Val Lys Val Arg Asn Lys His Lys Gly Lys Pro Thr Phe Met 
            260                 265                 270         


Glu Glu Val Leu Glu His Leu Pro Gly Lys Thr Gln Asp Glu Val Gln 
        275                 280                 285             


Gln His Glu Lys Trp Tyr Gln Lys Phe Leu Ala Leu Glu Glu Arg Lys 
    290                 295                 300                 


Lys Glu Ser Ile Gln Ile Trp Lys Thr Lys Lys Gln Gln Lys Arg Glu 
305                 310                 315                 320 


Glu Ile Phe Lys Leu Lys Glu Lys Ala Asp Asn Thr Pro Val Leu Phe 
                325                 330                 335     


His Asn Lys Gln Glu Asp Asn Gln Lys Gln Lys Glu Glu Gln Arg Lys 
            340                 345                 350         


Lys Gln Lys Leu Ala Val Glu Ala Trp Lys Lys Gln Lys Ser Ile Glu 
        355                 360                 365             


Met Ser Met Lys Cys Ala Ser Gln Leu Lys Glu Glu Glu Glu Lys Glu 
    370                 375                 380                 


Lys Lys His Gln Lys Glu Arg Gln Arg Gln Phe Lys Leu Lys Leu Leu 
385                 390                 395                 400 


Leu Glu Ser Tyr Thr Gln Gln Lys Lys Glu Gln Glu Glu Phe Leu Arg 
                405                 410                 415     


Leu Glu Lys Glu Ile Arg Glu Lys Ala Glu Lys Ala Glu Lys Arg Lys 
            420                 425                 430         


Asn Ala Ala Asp Glu Ile Ser Arg Phe Gln Glu Arg Asp Leu His Lys 
        435                 440                 445             


Leu Glu Leu Lys Ile Leu Asp Arg Gln Ala Lys Glu Asp Glu Lys Ser 
    450                 455                 460                 


Gln Lys Gln Arg Arg Leu Ala Lys Leu Lys Glu Lys Val Glu Asn Asn 
465                 470                 475                 480 


Val Ser Arg Asp Pro Ser Arg Leu Tyr Lys Pro Thr Lys Gly Trp Glu 
                485                 490                 495     


Glu Arg Thr Lys Lys Ile Gly Pro Thr Gly Ser Gly Pro Leu Leu His 
            500                 505                 510         


Ile Pro His Arg Ala Ile Pro Thr Trp Arg Gln Gly Ile Gln Arg Arg 
        515                 520                 525             


Val 
    


<210>  869
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  869

Met Asp Leu Arg Arg Arg Asp Tyr His Met Glu Arg Pro Leu Leu Asn 
1               5                   10                  15      


Gln Glu His Leu Glu Glu Leu Gly Arg Trp Gly Ser Ala Pro Arg Thr 
            20                  25                  30          


His Gln Trp Arg Thr Trp Leu Gln Cys Ser Arg Ala Arg Ala Tyr Ala 
        35                  40                  45              


Leu Leu Leu Gln His Leu Pro Val Leu Val Trp Leu Pro Arg Tyr Pro 
    50                  55                  60                  


Val Arg Asp Trp Leu Leu Gly Asp Leu Leu Ser Gly Leu Ser Val Ala 
65                  70                  75                  80  


Ile Met Gln Leu Pro Gln Gly Leu Ala Tyr Ala Leu Leu Ala Gly Leu 
                85                  90                  95      


Pro Pro Val Phe Gly Leu Tyr Ser Ser Phe Tyr Pro Val Phe Ile Tyr 
            100                 105                 110         


Phe Leu Phe Gly Thr Ser Arg His Ile Ser Val Gly Thr Phe Ala Val 
        115                 120                 125             


Met Ser Val Met Val Gly Ser Val Thr Glu Ser Leu Ala Pro Gln Ala 
    130                 135                 140                 


Leu Asn Asp Ser Met Ile Asn Glu Thr Ala Arg Asp Ala Ala Arg Val 
145                 150                 155                 160 


Gln Val Ala Ser Thr Leu Ser Val Leu Val Gly Leu Phe Gln Val Gly 
                165                 170                 175     


Leu Gly Leu Ile His Phe Gly Phe Val Val Thr Tyr Leu Ser Glu Pro 
            180                 185                 190         


Leu Val Arg Gly Tyr Thr Thr Ala Ala Ala Val Gln Val Phe Val Ser 
        195                 200                 205             


Gln Leu Lys Tyr Val Phe Gly Leu His Leu Ser Ser His Ser Gly Pro 
    210                 215                 220                 


Leu Ser Leu Ile Tyr Thr Val Leu Glu Val Cys Trp Lys Leu Pro Gln 
225                 230                 235                 240 


Ser Lys Val Gly Thr Val Val Thr Ala Ala Val Ala Gly Val Val Leu 
                245                 250                 255     


Val Val Val Lys Leu Leu Asn Asp Lys Leu Gln Gln Gln Leu Pro Met 
            260                 265                 270         


Pro Ile Pro Gly Glu Leu Leu Thr Leu Ile Gly Ala Thr Gly Ile Ser 
        275                 280                 285             


Tyr Gly Met Gly Leu Lys His Arg Phe Glu Val Asp Val Val Gly Asn 
    290                 295                 300                 


Ile Pro Ala Gly Leu Val Pro Pro Val Ala Pro Asn Thr Gln Leu Phe 
305                 310                 315                 320 


Ser Lys Leu Val Gly Ser Ala Phe Thr Ile Ala Val Val Gly Phe Ala 
                325                 330                 335     


Ile Ala Ile Ser Leu Gly Lys Ile Phe Ala Leu Arg His Gly Tyr Arg 
            340                 345                 350         


Val Asp Ser Asn Gln Glu Leu Val Ala Leu Gly Leu Ser Asn Leu Ile 
        355                 360                 365             


Gly Gly Ile Phe Gln Cys Phe Pro Val Ser Cys Ser Met Ser Arg Ser 
    370                 375                 380                 


Leu Val Gln Glu Ser Thr Gly Gly Asn Ser Gln Val Ala Gly Ala Ile 
385                 390                 395                 400 


Ser Ser Leu Phe Ile Leu Leu Ile Ile Val Lys Leu Gly Glu Leu Phe 
                405                 410                 415     


His Asp Leu Pro Lys Ala Val Leu Ala Ala Ile Ile Ile Val Asn Leu 
            420                 425                 430         


Lys Gly Met Leu Arg Gln Leu Ser Asp Met Arg Ser Leu Trp Lys Ala 
        435                 440                 445             


Asn Arg Ala Asp Leu Leu Ile Trp Leu Val Thr Phe Thr Ala Thr Ile 
    450                 455                 460                 


Leu Leu Asn Leu Asp Leu Gly Leu Val Val Ala Val Ile Phe Ser Leu 
465                 470                 475                 480 


Leu Leu Val Val Val Arg Thr Gln Met Pro His Tyr Ser Val Leu Gly 
                485                 490                 495     


Gln Val Pro Asp Thr Asp Ile Tyr Arg Asp Val Ala Glu Tyr Ser Glu 
            500                 505                 510         


Ala Lys Glu Val Arg Gly Val Lys Val Phe Arg Ser Ser Ala Thr Val 
        515                 520                 525             


Tyr Phe Ala Asn Ala Glu Phe Tyr Ser Asp Ala Leu Lys Gln Arg Cys 
    530                 535                 540                 


Gly Val Asp Val Asp Phe Leu Ile Ser Gln Lys Lys Lys Leu Leu Lys 
545                 550                 555                 560 


Lys Gln Glu Gln Leu Lys Leu Lys Gln Leu Gln Lys Glu Glu Lys Leu 
                565                 570                 575     


Arg Lys Gln Ala Ala Ser Pro Lys Gly Ala Ser Val Ser Ile Asn Val 
            580                 585                 590         


Asn Thr Ser Leu Glu Asp Met Arg Ser Asn Asn Val Glu Asp Cys Lys 
        595                 600                 605             


Met Met Gln Val Ser Ser Gly Asp Lys Met Glu Asp Ala Thr Ala Asn 
    610                 615                 620                 


Gly Gln Glu Asp Ser Lys Ala Pro Asp Gly Ser Thr Leu Lys Ala Leu 
625                 630                 635                 640 


Gly Leu Pro Gln Pro Asp Phe His Ser Leu Ile Leu Asp Leu Gly Ala 
                645                 650                 655     


Leu Ser Phe Val Asp Thr Val Cys Leu Lys Ser Leu Lys Asn Ile Phe 
            660                 665                 670         


His Asp Phe Arg Glu Ile Glu Val Glu Val Tyr Met Ala Ala Cys His 
        675                 680                 685             


Ser Pro Val Val Ser Gln Leu Glu Ala Gly His Phe Phe Asp Ala Ser 
    690                 695                 700                 


Ile Thr Lys Lys His Leu Phe Ala Ser Val His Asp Ala Val Thr Phe 
705                 710                 715                 720 


Ala Leu Gln His Pro Arg Pro Val Pro Asp Ser Pro Val Ser Val Thr 
                725                 730                 735     


Arg Leu 
        


<210>  870
<211>  3312
<212>  PRT
<213>  Homo sapiens

<400>  870

Met Met Ala Arg Arg Pro Pro Trp Arg Gly Leu Gly Gly Arg Ser Thr 
1               5                   10                  15      


Pro Ile Leu Leu Leu Leu Leu Leu Ser Leu Phe Pro Leu Ser Gln Glu 
            20                  25                  30          


Glu Leu Gly Gly Gly Gly His Gln Gly Trp Asp Pro Gly Leu Ala Ala 
        35                  40                  45              


Thr Thr Gly Pro Arg Ala His Ile Gly Gly Gly Ala Leu Ala Leu Cys 
    50                  55                  60                  


Pro Glu Ser Ser Gly Val Arg Glu Asp Gly Gly Pro Gly Leu Gly Val 
65                  70                  75                  80  


Arg Glu Pro Ile Phe Val Gly Leu Arg Gly Arg Arg Gln Ser Ala Arg 
                85                  90                  95      


Asn Ser Arg Gly Pro Pro Glu Gln Pro Asn Glu Glu Leu Gly Ile Glu 
            100                 105                 110         


His Gly Val Gln Pro Leu Gly Ser Arg Glu Arg Glu Thr Gly Gln Gly 
        115                 120                 125             


Pro Gly Ser Val Leu Tyr Trp Arg Pro Glu Val Ser Ser Cys Gly Arg 
    130                 135                 140                 


Thr Gly Pro Leu Gln Arg Gly Ser Leu Ser Pro Gly Ala Leu Ser Ser 
145                 150                 155                 160 


Gly Val Pro Gly Ser Gly Asn Ser Ser Pro Leu Pro Ser Asp Phe Leu 
                165                 170                 175     


Ile Arg His His Gly Pro Lys Pro Val Ser Ser Gln Arg Asn Ala Gly 
            180                 185                 190         


Thr Gly Ser Arg Lys Arg Val Gly Thr Ala Arg Cys Cys Gly Glu Leu 
        195                 200                 205             


Trp Ala Thr Gly Ser Lys Gly Gln Gly Glu Arg Ala Thr Thr Ser Gly 
    210                 215                 220                 


Ala Glu Arg Thr Ala Pro Arg Arg Asn Cys Leu Pro Gly Ala Ser Gly 
225                 230                 235                 240 


Ser Gly Pro Glu Leu Asp Ser Ala Pro Arg Thr Ala Arg Thr Ala Pro 
                245                 250                 255     


Ala Ser Gly Ser Ala Pro Arg Glu Ser Arg Thr Ala Pro Glu Pro Ala 
            260                 265                 270         


Pro Lys Arg Met Arg Ser Arg Gly Leu Phe Arg Cys Arg Phe Leu Pro 
        275                 280                 285             


Gln Arg Pro Gly Pro Arg Pro Pro Gly Leu Pro Ala Arg Pro Glu Ala 
    290                 295                 300                 


Arg Lys Val Thr Ser Ala Asn Arg Ala Arg Phe Arg Arg Ala Ala Asn 
305                 310                 315                 320 


Arg His Pro Gln Phe Pro Gln Tyr Asn Tyr Gln Thr Leu Val Pro Glu 
                325                 330                 335     


Asn Glu Ala Ala Gly Thr Ala Val Leu Arg Val Val Ala Gln Asp Pro 
            340                 345                 350         


Asp Ala Gly Glu Ala Gly Arg Leu Val Tyr Ser Leu Ala Ala Leu Met 
        355                 360                 365             


Asn Ser Arg Ser Leu Glu Leu Phe Ser Ile Asp Pro Gln Ser Gly Leu 
    370                 375                 380                 


Ile Arg Thr Ala Ala Ala Leu Asp Arg Glu Ser Met Glu Arg His Tyr 
385                 390                 395                 400 


Leu Arg Val Thr Ala Gln Asp His Gly Ser Pro Arg Leu Ser Ala Thr 
                405                 410                 415     


Thr Met Val Ala Val Thr Val Ala Asp Arg Asn Asp His Ser Pro Val 
            420                 425                 430         


Phe Glu Gln Ala Gln Tyr Arg Glu Thr Leu Arg Glu Asn Val Glu Glu 
        435                 440                 445             


Gly Tyr Pro Ile Leu Gln Leu Arg Ala Thr Asp Gly Asp Ala Pro Pro 
    450                 455                 460                 


Asn Ala Asn Leu Arg Tyr Arg Phe Val Gly Pro Pro Ala Ala Arg Ala 
465                 470                 475                 480 


Ala Ala Ala Ala Ala Phe Glu Ile Asp Pro Arg Ser Gly Leu Ile Ser 
                485                 490                 495     


Thr Ser Gly Arg Val Asp Arg Glu His Met Glu Ser Tyr Glu Leu Val 
            500                 505                 510         


Val Glu Ala Ser Asp Gln Gly Gln Glu Pro Gly Pro Arg Ser Ala Thr 
        515                 520                 525             


Val Arg Val His Ile Thr Val Leu Asp Glu Asn Asp Asn Ala Pro Gln 
    530                 535                 540                 


Phe Ser Glu Lys Arg Tyr Val Ala Gln Val Arg Glu Asp Val Arg Pro 
545                 550                 555                 560 


His Thr Val Val Leu Arg Val Thr Ala Thr Asp Arg Asp Lys Asp Ala 
                565                 570                 575     


Asn Gly Leu Val His Tyr Asn Ile Ile Ser Gly Asn Ser Arg Gly His 
            580                 585                 590         


Phe Ala Ile Asp Ser Leu Thr Gly Glu Ile Gln Val Val Ala Pro Leu 
        595                 600                 605             


Asp Phe Glu Ala Glu Arg Glu Tyr Ala Leu Arg Ile Arg Ala Gln Asp 
    610                 615                 620                 


Ala Gly Arg Pro Pro Leu Ser Asn Asn Thr Gly Leu Ala Ser Ile Gln 
625                 630                 635                 640 


Val Val Asp Ile Asn Asp His Ile Pro Ile Phe Val Ser Thr Pro Phe 
                645                 650                 655     


Gln Val Ser Val Leu Glu Asn Ala Pro Leu Gly His Ser Val Ile His 
            660                 665                 670         


Ile Gln Ala Val Asp Ala Asp His Gly Glu Asn Ala Arg Leu Glu Tyr 
        675                 680                 685             


Ser Leu Thr Gly Val Ala Pro Asp Thr Pro Phe Val Ile Asn Ser Ala 
    690                 695                 700                 


Thr Gly Trp Val Ser Val Ser Gly Pro Leu Asp Arg Glu Ser Val Glu 
705                 710                 715                 720 


His Tyr Phe Phe Gly Val Glu Ala Arg Asp His Gly Ser Pro Pro Leu 
                725                 730                 735     


Ser Ala Ser Ala Ser Val Thr Val Thr Val Leu Asp Val Asn Asp Asn 
            740                 745                 750         


Arg Pro Glu Phe Thr Met Lys Glu Tyr His Leu Arg Leu Asn Glu Asp 
        755                 760                 765             


Ala Ala Val Gly Thr Ser Val Val Ser Val Thr Ala Val Asp Arg Asp 
    770                 775                 780                 


Ala Asn Ser Ala Ile Ser Tyr Gln Ile Thr Gly Gly Asn Thr Arg Asn 
785                 790                 795                 800 


Arg Phe Ala Ile Ser Thr Gln Gly Gly Val Gly Leu Val Thr Leu Ala 
                805                 810                 815     


Leu Pro Leu Asp Tyr Lys Gln Glu Arg Tyr Phe Lys Leu Val Leu Thr 
            820                 825                 830         


Ala Ser Asp Arg Ala Leu His Asp His Cys Tyr Val His Ile Asn Ile 
        835                 840                 845             


Thr Asp Ala Asn Thr His Arg Pro Val Phe Gln Ser Ala His Tyr Ser 
    850                 855                 860                 


Val Ser Val Asn Glu Asp Arg Pro Met Gly Ser Thr Ile Val Val Ile 
865                 870                 875                 880 


Ser Ala Ser Asp Asp Asp Val Gly Glu Asn Ala Arg Ile Thr Tyr Leu 
                885                 890                 895     


Leu Glu Asp Asn Leu Pro Gln Phe Arg Ile Asp Ala Asp Ser Gly Ala 
            900                 905                 910         


Ile Thr Leu Gln Ala Pro Leu Asp Tyr Glu Asp Gln Val Thr Tyr Thr 
        915                 920                 925             


Leu Ala Ile Thr Ala Arg Asp Asn Gly Ile Pro Gln Lys Ala Asp Thr 
    930                 935                 940                 


Thr Tyr Val Glu Val Met Val Asn Asp Val Asn Asp Asn Ala Pro Gln 
945                 950                 955                 960 


Phe Val Ala Ser His Tyr Thr Gly Leu Val Ser Glu Asp Ala Pro Pro 
                965                 970                 975     


Phe Thr Ser Val Leu Gln Ile Ser Ala Thr Asp Arg Asp Ala His Ala 
            980                 985                 990         


Asn Gly Arg Val Gln Tyr Thr Phe  Gln Asn Gly Glu Asp  Gly Asp Gly 
        995                 1000                 1005             


Asp Phe  Thr Ile Glu Pro Thr  Ser Gly Ile Val Arg  Thr Val Arg 
    1010                 1015                 1020             


Arg Leu  Asp Arg Glu Ala Val  Ser Val Tyr Glu Leu  Thr Ala Tyr 
    1025                 1030                 1035             


Ala Val  Asp Arg Gly Val Pro  Pro Leu Arg Thr Pro  Val Ser Ile 
    1040                 1045                 1050             


Gln Val  Met Val Gln Asp Val  Asn Asp Asn Ala Pro  Val Phe Pro 
    1055                 1060                 1065             


Ala Glu  Glu Phe Glu Val Arg  Val Lys Glu Asn Ser  Ile Val Gly 
    1070                 1075                 1080             


Ser Val  Val Ala Gln Ile Thr  Ala Val Asp Pro Asp  Glu Gly Pro 
    1085                 1090                 1095             


Asn Ala  His Ile Met Tyr Gln  Ile Val Glu Gly Asn  Ile Pro Glu 
    1100                 1105                 1110             


Leu Phe  Gln Met Asp Ile Phe  Ser Gly Glu Leu Thr  Ala Leu Ile 
    1115                 1120                 1125             


Asp Leu  Asp Tyr Glu Ala Arg  Gln Glu Tyr Val Ile  Val Val Gln 
    1130                 1135                 1140             


Ala Thr  Ser Ala Pro Leu Val  Ser Arg Ala Thr Val  His Val Arg 
    1145                 1150                 1155             


Leu Val  Asp Gln Asn Asp Asn  Ser Pro Val Leu Asn  Asn Phe Gln 
    1160                 1165                 1170             


Ile Leu  Phe Asn Asn Tyr Val  Ser Asn Arg Ser Asp  Thr Phe Pro 
    1175                 1180                 1185             


Ser Gly  Ile Ile Gly Arg Ile  Pro Ala Tyr Asp Pro  Asp Val Ser 
    1190                 1195                 1200             


Asp His  Leu Phe Tyr Ser Phe  Glu Arg Gly Asn Glu  Leu Gln Leu 
    1205                 1210                 1215             


Leu Val  Val Asn Gln Thr Ser  Gly Glu Leu Arg Leu  Ser Arg Lys 
    1220                 1225                 1230             


Leu Asp  Asn Asn Arg Pro Leu  Val Ala Ser Met Leu  Val Thr Val 
    1235                 1240                 1245             


Thr Asp  Gly Leu His Ser Val  Thr Ala Gln Cys Val  Leu Arg Val 
    1250                 1255                 1260             


Val Ile  Ile Thr Glu Glu Leu  Leu Ala Asn Ser Leu  Thr Val Arg 
    1265                 1270                 1275             


Leu Glu  Asn Met Trp Gln Glu  Arg Phe Leu Ser Pro  Leu Leu Gly 
    1280                 1285                 1290             


Arg Phe  Leu Glu Gly Val Ala  Ala Val Leu Ala Thr  Pro Ala Glu 
    1295                 1300                 1305             


Asp Val  Phe Ile Phe Asn Ile  Gln Asn Asp Thr Asp  Val Gly Gly 
    1310                 1315                 1320             


Thr Val  Leu Asn Val Ser Phe  Ser Ala Leu Ala Pro  Arg Gly Ala 
    1325                 1330                 1335             


Gly Ala  Gly Ala Ala Gly Pro  Trp Phe Ser Ser Glu  Glu Leu Gln 
    1340                 1345                 1350             


Glu Gln  Leu Tyr Val Arg Arg  Ala Ala Leu Ala Ala  Arg Ser Leu 
    1355                 1360                 1365             


Leu Asp  Val Leu Pro Phe Asp  Asp Asn Val Cys Leu  Arg Glu Pro 
    1370                 1375                 1380             


Cys Glu  Asn Tyr Met Lys Cys  Val Ser Val Leu Arg  Phe Asp Ser 
    1385                 1390                 1395             


Ser Ala  Pro Phe Leu Ala Ser  Ala Ser Thr Leu Phe  Arg Pro Ile 
    1400                 1405                 1410             


Gln Pro  Ile Ala Gly Leu Arg  Cys Arg Cys Pro Pro  Gly Phe Thr 
    1415                 1420                 1425             


Gly Asp  Phe Cys Glu Thr Glu  Leu Asp Leu Cys Tyr  Ser Asn Pro 
    1430                 1435                 1440             


Cys Arg  Asn Gly Gly Ala Cys  Ala Arg Arg Glu Gly  Gly Tyr Thr 
    1445                 1450                 1455             


Cys Val  Cys Arg Pro Arg Phe  Thr Gly Glu Asp Cys  Glu Leu Asp 
    1460                 1465                 1470             


Thr Glu  Ala Gly Arg Cys Val  Pro Gly Val Cys Arg  Asn Gly Gly 
    1475                 1480                 1485             


Thr Cys  Thr Asp Ala Pro Asn  Gly Gly Phe Arg Cys  Gln Cys Pro 
    1490                 1495                 1500             


Ala Gly  Gly Ala Phe Glu Gly  Pro Arg Cys Glu Val  Ala Ala Arg 
    1505                 1510                 1515             


Ser Phe  Pro Pro Ser Ser Phe  Val Met Phe Arg Gly  Leu Arg Gln 
    1520                 1525                 1530             


Arg Phe  His Leu Thr Leu Ser  Leu Ser Phe Ala Thr  Val Gln Gln 
    1535                 1540                 1545             


Ser Gly  Leu Leu Phe Tyr Asn  Gly Arg Leu Asn Glu  Lys His Asp 
    1550                 1555                 1560             


Phe Leu  Ala Leu Glu Leu Val  Ala Gly Gln Val Arg  Leu Thr Tyr 
    1565                 1570                 1575             


Ser Thr  Gly Glu Ser Asn Thr  Val Val Ser Pro Thr  Val Pro Gly 
    1580                 1585                 1590             


Gly Leu  Ser Asp Gly Gln Trp  His Thr Val His Leu  Arg Tyr Tyr 
    1595                 1600                 1605             


Asn Lys  Pro Arg Thr Asp Ala  Leu Gly Gly Ala Gln  Gly Pro Ser 
    1610                 1615                 1620             


Lys Asp  Lys Val Ala Val Leu  Ser Val Asp Asp Cys  Asp Val Ala 
    1625                 1630                 1635             


Val Ala  Leu Gln Phe Gly Ala  Glu Ile Gly Asn Tyr  Ser Cys Ala 
    1640                 1645                 1650             


Ala Ala  Gly Val Gln Thr Ser  Ser Lys Lys Ser Leu  Asp Leu Thr 
    1655                 1660                 1665             


Gly Pro  Leu Leu Leu Gly Gly  Val Pro Asn Leu Pro  Glu Asn Phe 
    1670                 1675                 1680             


Pro Val  Ser His Lys Asp Phe  Ile Gly Cys Met Arg  Asp Leu His 
    1685                 1690                 1695             


Ile Asp  Gly Arg Arg Val Asp  Met Ala Ala Phe Val  Ala Asn Asn 
    1700                 1705                 1710             


Gly Thr  Met Ala Gly Cys Gln  Ala Lys Leu His Phe  Cys Asp Ser 
    1715                 1720                 1725             


Gly Pro  Cys Lys Asn Ser Gly  Phe Cys Ser Glu Arg  Trp Gly Ser 
    1730                 1735                 1740             


Phe Ser  Cys Asp Cys Pro Val  Gly Phe Gly Gly Lys  Asp Cys Gln 
    1745                 1750                 1755             


Leu Thr  Met Ala His Pro His  His Phe Arg Gly Asn  Gly Thr Leu 
    1760                 1765                 1770             


Ser Trp  Asn Phe Gly Ser Asp  Met Ala Val Ser Val  Pro Trp Tyr 
    1775                 1780                 1785             


Leu Gly  Leu Ala Phe Arg Thr  Arg Ala Thr Gln Gly  Val Leu Met 
    1790                 1795                 1800             


Gln Val  Gln Ala Gly Pro His  Ser Thr Leu Leu Cys  Gln Leu Asp 
    1805                 1810                 1815             


Arg Gly  Leu Leu Ser Val Thr  Val Thr Arg Gly Ser  Gly Arg Ala 
    1820                 1825                 1830             


Ser His  Leu Leu Leu Asp Gln  Val Thr Val Ser Asp  Gly Arg Trp 
    1835                 1840                 1845             


His Asp  Leu Arg Leu Glu Leu  Gln Glu Glu Pro Gly  Gly Arg Arg 
    1850                 1855                 1860             


Gly His  His Val Leu Met Val  Ser Leu Asp Phe Ser  Leu Phe Gln 
    1865                 1870                 1875             


Asp Thr  Met Ala Val Gly Ser  Glu Leu Gln Gly Leu  Lys Val Lys 
    1880                 1885                 1890             


Gln Leu  His Val Gly Gly Leu  Pro Pro Gly Ser Ala  Glu Glu Ala 
    1895                 1900                 1905             


Pro Gln  Gly Leu Val Gly Cys  Ile Gln Gly Val Trp  Leu Gly Ser 
    1910                 1915                 1920             


Thr Pro  Ser Gly Ser Pro Ala  Leu Leu Pro Pro Ser  His Arg Val 
    1925                 1930                 1935             


Asn Ala  Glu Pro Gly Cys Val  Val Thr Asn Ala Cys  Ala Ser Gly 
    1940                 1945                 1950             


Pro Cys  Pro Pro His Ala Asp  Cys Arg Asp Leu Trp  Gln Thr Phe 
    1955                 1960                 1965             


Ser Cys  Thr Cys Gln Pro Gly  Tyr Tyr Gly Pro Gly  Cys Val Asp 
    1970                 1975                 1980             


Ala Cys  Leu Leu Asn Pro Cys  Gln Asn Gln Gly Ser  Cys Arg His 
    1985                 1990                 1995             


Leu Pro  Gly Ala Pro His Gly  Tyr Thr Cys Asp Cys  Val Gly Gly 
    2000                 2005                 2010             


Tyr Phe  Gly His His Cys Glu  His Arg Met Asp Gln  Gln Cys Pro 
    2015                 2020                 2025             


Arg Gly  Trp Trp Gly Ser Pro  Thr Cys Gly Pro Cys  Asn Cys Asp 
    2030                 2035                 2040             


Val His  Lys Gly Phe Asp Pro  Asn Cys Asn Lys Thr  Asn Gly Gln 
    2045                 2050                 2055             


Cys His  Cys Lys Glu Phe His  Tyr Arg Pro Arg Gly  Ser Asp Ser 
    2060                 2065                 2070             


Cys Leu  Pro Cys Asp Cys Tyr  Pro Val Gly Ser Thr  Ser Arg Ser 
    2075                 2080                 2085             


Cys Ala  Pro His Ser Gly Gln  Cys Pro Cys Arg Pro  Gly Ala Leu 
    2090                 2095                 2100             


Gly Arg  Gln Cys Asn Ser Cys  Asp Ser Pro Phe Ala  Glu Val Thr 
    2105                 2110                 2115             


Ala Ser  Gly Cys Arg Val Leu  Tyr Asp Ala Cys Pro  Lys Ser Leu 
    2120                 2125                 2130             


Arg Ser  Gly Val Trp Trp Pro  Gln Thr Lys Phe Gly  Val Leu Ala 
    2135                 2140                 2145             


Thr Val  Pro Cys Pro Arg Gly  Ala Leu Gly Ala Ala  Val Arg Leu 
    2150                 2155                 2160             


Cys Asp  Glu Ala Gln Gly Trp  Leu Glu Pro Asp Leu  Phe Asn Cys 
    2165                 2170                 2175             


Thr Ser  Pro Ala Phe Arg Glu  Leu Ser Leu Leu Leu  Asp Gly Leu 
    2180                 2185                 2190             


Glu Leu  Asn Lys Thr Ala Leu  Asp Thr Met Glu Ala  Lys Lys Leu 
    2195                 2200                 2205             


Ala Gln  Arg Leu Arg Glu Val  Thr Gly His Thr Asp  His Tyr Phe 
    2210                 2215                 2220             


Ser Gln  Asp Val Arg Val Thr  Ala Arg Leu Leu Ala  His Leu Leu 
    2225                 2230                 2235             


Ala Phe  Glu Ser His Gln Gln  Gly Phe Gly Leu Thr  Ala Thr Gln 
    2240                 2245                 2250             


Asp Ala  His Phe Asn Glu Asn  Leu Leu Trp Ala Gly  Ser Ala Leu 
    2255                 2260                 2265             


Leu Ala  Pro Glu Thr Gly Asp  Leu Trp Ala Ala Leu  Gly Gln Arg 
    2270                 2275                 2280             


Ala Pro  Gly Gly Ser Pro Gly  Ser Ala Gly Leu Val  Arg His Leu 
    2285                 2290                 2295             


Glu Glu  Tyr Ala Ala Thr Leu  Ala Arg Asn Met Glu  Leu Thr Tyr 
    2300                 2305                 2310             


Leu Asn  Pro Met Gly Leu Val  Thr Pro Asn Ile Met  Leu Ser Ile 
    2315                 2320                 2325             


Asp Arg  Met Glu His Pro Ser  Ser Pro Arg Gly Ala  Arg Arg Tyr 
    2330                 2335                 2340             


Pro Arg  Tyr His Ser Asn Leu  Phe Arg Gly Gln Asp  Ala Trp Asp 
    2345                 2350                 2355             


Pro His  Thr His Val Leu Leu  Pro Ser Gln Ser Pro  Arg Pro Ser 
    2360                 2365                 2370             


Pro Ser  Glu Val Leu Pro Thr  Ser Ser Ser Ile Glu  Asn Ser Thr 
    2375                 2380                 2385             


Thr Ser  Ser Val Val Pro Pro  Pro Ala Pro Pro Glu  Pro Glu Pro 
    2390                 2395                 2400             


Gly Ile  Ser Ile Ile Ile Leu  Leu Val Tyr Arg Thr  Leu Gly Gly 
    2405                 2410                 2415             


Leu Leu  Pro Ala Gln Phe Gln  Ala Glu Arg Arg Gly  Ala Arg Leu 
    2420                 2425                 2430             


Pro Gln  Asn Pro Val Met Asn  Ser Pro Val Val Ser  Val Ala Val 
    2435                 2440                 2445             


Phe His  Gly Arg Asn Phe Leu  Arg Gly Ile Leu Glu  Ser Pro Ile 
    2450                 2455                 2460             


Ser Leu  Glu Phe Arg Leu Leu  Gln Thr Ala Asn Arg  Ser Lys Ala 
    2465                 2470                 2475             


Ile Cys  Val Gln Trp Asp Pro  Pro Gly Leu Ala Glu  Gln His Gly 
    2480                 2485                 2490             


Val Trp  Thr Ala Arg Asp Cys  Glu Leu Val His Arg  Asn Gly Ser 
    2495                 2500                 2505             


His Ala  Arg Cys Arg Cys Ser  Arg Thr Gly Thr Phe  Gly Val Leu 
    2510                 2515                 2520             


Met Asp  Ala Ser Pro Arg Glu  Arg Leu Glu Gly Asp  Leu Glu Leu 
    2525                 2530                 2535             


Leu Ala  Val Phe Thr His Val  Val Val Ala Val Ser  Val Ala Ala 
    2540                 2545                 2550             


Leu Val  Leu Thr Ala Ala Ile  Leu Leu Ser Leu Arg  Ser Leu Lys 
    2555                 2560                 2565             


Ser Asn  Val Arg Gly Ile His  Ala Asn Val Ala Ala  Ala Leu Gly 
    2570                 2575                 2580             


Val Ala  Glu Leu Leu Phe Leu  Leu Gly Ile His Arg  Thr His Asn 
    2585                 2590                 2595             


Gln Leu  Val Cys Thr Ala Val  Ala Ile Leu Leu His  Tyr Phe Phe 
    2600                 2605                 2610             


Leu Ser  Thr Phe Ala Trp Leu  Phe Val Gln Gly Leu  His Leu Tyr 
    2615                 2620                 2625             


Arg Met  Gln Val Glu Pro Arg  Asn Val Asp Arg Gly  Ala Met Arg 
    2630                 2635                 2640             


Phe Tyr  His Ala Leu Gly Trp  Gly Val Pro Ala Val  Leu Leu Gly 
    2645                 2650                 2655             


Leu Ala  Val Gly Leu Asp Pro  Glu Gly Tyr Gly Asn  Pro Asp Phe 
    2660                 2665                 2670             


Cys Trp  Ile Ser Val His Glu  Pro Leu Ile Trp Ser  Phe Ala Gly 
    2675                 2680                 2685             


Pro Val  Val Leu Val Ile Val  Met Asn Gly Thr Met  Phe Leu Leu 
    2690                 2695                 2700             


Ala Ala  Arg Thr Ser Cys Ser  Thr Gly Gln Arg Glu  Ala Lys Lys 
    2705                 2710                 2715             


Thr Ser  Ala Leu Thr Leu Arg  Ser Ser Phe Leu Leu  Leu Leu Leu 
    2720                 2725                 2730             


Val Ser  Ala Ser Trp Leu Phe  Gly Leu Leu Ala Val  Asn His Ser 
    2735                 2740                 2745             


Ile Leu  Ala Phe His Tyr Leu  His Ala Gly Leu Cys  Gly Leu Gln 
    2750                 2755                 2760             


Gly Leu  Ala Val Leu Leu Leu  Phe Cys Val Leu Asn  Ala Asp Ala 
    2765                 2770                 2775             


Arg Ala  Ala Trp Met Pro Ala  Cys Leu Gly Arg Lys  Ala Ala Pro 
    2780                 2785                 2790             


Glu Glu  Ala Arg Pro Ala Pro  Gly Leu Gly Pro Gly  Ala Tyr Asn 
    2795                 2800                 2805             


Asn Thr  Ala Leu Phe Glu Glu  Ser Gly Leu Ile Arg  Ile Thr Leu 
    2810                 2815                 2820             


Gly Ala  Ser Thr Val Ser Ser  Val Ser Ser Ala Arg  Ser Gly Arg 
    2825                 2830                 2835             


Thr Gln  Asp Gln Asp Ser Gln  Arg Gly Arg Ser Tyr  Leu Arg Asp 
    2840                 2845                 2850             


Asn Val  Leu Val Arg His Gly  Ser Ala Ala Asp His  Thr Asp His 
    2855                 2860                 2865             


Ser Leu  Gln Ala His Ala Gly  Pro Thr Asp Leu Asp  Val Ala Met 
    2870                 2875                 2880             


Phe His  Arg Asp Ala Gly Ala  Asp Ser Asp Ser Asp  Ser Asp Leu 
    2885                 2890                 2895             


Ser Leu  Glu Glu Glu Arg Ser  Leu Ser Ile Pro Ser  Ser Glu Ser 
    2900                 2905                 2910             


Glu Asp  Asn Gly Arg Thr Arg  Gly Arg Phe Gln Arg  Pro Leu Cys 
    2915                 2920                 2925             


Arg Ala  Ala Gln Ser Glu Arg  Leu Leu Thr His Pro  Lys Asp Val 
    2930                 2935                 2940             


Asp Gly  Asn Asp Leu Leu Ser  Tyr Trp Pro Ala Leu  Gly Glu Cys 
    2945                 2950                 2955             


Glu Ala  Ala Pro Cys Ala Leu  Gln Thr Trp Gly Ser  Glu Arg Arg 
    2960                 2965                 2970             


Leu Gly  Leu Asp Thr Ser Lys  Asp Ala Ala Asn Asn  Asn Gln Pro 
    2975                 2980                 2985             


Asp Pro  Ala Leu Thr Ser Gly  Asp Glu Thr Ser Leu  Gly Arg Ala 
    2990                 2995                 3000             


Gln Arg  Gln Arg Lys Gly Ile  Leu Lys Asn Arg Leu  Gln Tyr Pro 
    3005                 3010                 3015             


Leu Val  Pro Gln Thr Arg Gly  Ala Pro Glu Leu Ser  Trp Cys Arg 
    3020                 3025                 3030             


Ala Ala  Thr Leu Gly His Arg  Ala Val Pro Ala Ala  Ser Tyr Gly 
    3035                 3040                 3045             


Arg Ile  Tyr Ala Gly Gly Gly  Thr Gly Ser Leu Ser  Gln Pro Ala 
    3050                 3055                 3060             


Ser Arg  Tyr Ser Ser Arg Glu  Gln Leu Asp Leu Leu  Leu Arg Arg 
    3065                 3070                 3075             


Gln Leu  Ser Arg Glu Arg Leu  Glu Glu Ala Pro Ala  Pro Val Leu 
    3080                 3085                 3090             


Arg Pro  Leu Ser Arg Pro Gly  Ser Gln Glu Cys Met  Asp Ala Ala 
    3095                 3100                 3105             


Pro Gly  Arg Leu Glu Pro Lys  Asp Arg Gly Ser Thr  Leu Pro Arg 
    3110                 3115                 3120             


Arg Gln  Pro Pro Arg Asp Tyr  Pro Gly Ala Met Ala  Gly Arg Phe 
    3125                 3130                 3135             


Gly Ser  Arg Asp Ala Leu Asp  Leu Gly Ala Pro Arg  Glu Trp Leu 
    3140                 3145                 3150             


Ser Thr  Leu Pro Pro Pro Arg  Arg Thr Arg Asp Leu  Asp Pro Gln 
    3155                 3160                 3165             


Pro Pro  Pro Leu Pro Leu Ser  Pro Gln Arg Gln Leu  Ser Arg Asp 
    3170                 3175                 3180             


Pro Leu  Leu Pro Ser Arg Pro  Leu Asp Ser Leu Ser  Arg Ser Ser 
    3185                 3190                 3195             


Asn Ser  Arg Glu Gln Leu Asp  Gln Val Pro Ser Arg  His Pro Ser 
    3200                 3205                 3210             


Arg Glu  Ala Leu Gly Pro Leu  Pro Gln Leu Leu Arg  Ala Arg Glu 
    3215                 3220                 3225             


Asp Ser  Val Ser Gly Pro Ser  His Gly Pro Ser Thr  Glu Gln Leu 
    3230                 3235                 3240             


Asp Ile  Leu Ser Ser Ile Leu  Ala Ser Phe Asn Ser  Ser Ala Leu 
    3245                 3250                 3255             


Ser Ser  Val Gln Ser Ser Ser  Thr Pro Leu Gly Pro  His Thr Thr 
    3260                 3265                 3270             


Ala Thr  Pro Ser Ala Thr Ala  Ser Val Leu Gly Pro  Ser Thr Pro 
    3275                 3280                 3285             


Arg Ser  Ala Thr Ser His Ser  Ile Ser Glu Leu Ser  Pro Asp Ser 
    3290                 3295                 3300             


Glu Val  Pro Arg Ser Glu Gly  His Ser 
    3305                 3310         


<210>  871
<211>  832
<212>  PRT
<213>  Homo sapiens

<400>  871

Met Phe Ala Leu Gly Leu Pro Phe Leu Val Leu Leu Val Ala Ser Val 
1               5                   10                  15      


Glu Ser His Leu Gly Val Leu Gly Pro Lys Asn Val Ser Gln Lys Asp 
            20                  25                  30          


Ala Glu Phe Glu Arg Thr Tyr Val Asp Glu Val Asn Ser Glu Leu Val 
        35                  40                  45              


Asn Ile Tyr Thr Phe Asn His Thr Val Thr Arg Asn Arg Thr Glu Gly 
    50                  55                  60                  


Val Arg Val Ser Val Asn Val Leu Asn Lys Gln Lys Gly Ala Pro Leu 
65                  70                  75                  80  


Leu Phe Val Val Arg Gln Lys Glu Ala Val Val Ser Phe Gln Val Pro 
                85                  90                  95      


Leu Ile Leu Arg Gly Met Phe Gln Arg Lys Tyr Leu Tyr Gln Lys Val 
            100                 105                 110         


Glu Arg Thr Leu Cys Gln Pro Pro Thr Lys Asn Glu Ser Glu Ile Gln 
        115                 120                 125             


Phe Phe Tyr Val Asp Val Ser Thr Leu Ser Pro Val Asn Thr Thr Tyr 
    130                 135                 140                 


Gln Leu Arg Val Ser Arg Met Asp Asp Phe Val Leu Arg Thr Gly Glu 
145                 150                 155                 160 


Gln Phe Ser Phe Asn Thr Thr Ala Ala Gln Pro Gln Tyr Phe Lys Tyr 
                165                 170                 175     


Glu Phe Pro Glu Gly Val Asp Ser Val Ile Val Lys Val Thr Ser Asn 
            180                 185                 190         


Lys Ala Phe Pro Cys Ser Val Ile Ser Ile Gln Asp Val Leu Cys Pro 
        195                 200                 205             


Val Tyr Asp Leu Asp Asn Asn Val Ala Phe Ile Gly Met Tyr Gln Thr 
    210                 215                 220                 


Met Thr Lys Lys Ala Ala Ile Thr Val Gln Arg Lys Asp Phe Pro Ser 
225                 230                 235                 240 


Asn Ser Phe Tyr Val Val Val Val Val Lys Thr Glu Asp Gln Ala Cys 
                245                 250                 255     


Gly Gly Ser Leu Pro Phe Tyr Pro Phe Ala Glu Asp Glu Pro Val Asp 
            260                 265                 270         


Gln Gly His Arg Gln Lys Thr Leu Ser Val Leu Val Ser Gln Ala Val 
        275                 280                 285             


Thr Ser Glu Ala Tyr Val Ser Gly Met Leu Phe Cys Leu Gly Ile Phe 
    290                 295                 300                 


Leu Ser Phe Tyr Leu Leu Thr Val Leu Leu Ala Cys Trp Glu Asn Trp 
305                 310                 315                 320 


Arg Gln Lys Lys Lys Thr Leu Leu Val Ala Ile Asp Arg Ala Cys Pro 
                325                 330                 335     


Glu Ser Gly His Pro Arg Val Leu Ala Asp Ser Phe Pro Gly Ser Ser 
            340                 345                 350         


Pro Tyr Glu Gly Tyr Asn Tyr Gly Ser Phe Glu Asn Val Ser Gly Ser 
        355                 360                 365             


Thr Asp Gly Leu Val Asp Ser Ala Gly Thr Gly Asp Leu Ser Tyr Gly 
    370                 375                 380                 


Tyr Gln Gly Arg Ser Phe Glu Pro Val Gly Thr Arg Pro Arg Val Asp 
385                 390                 395                 400 


Ser Met Ser Ser Val Glu Glu Asp Asp Tyr Asp Thr Leu Thr Asp Ile 
                405                 410                 415     


Asp Ser Asp Lys Asn Val Ile Arg Thr Lys Gln Tyr Leu Tyr Val Ala 
            420                 425                 430         


Asp Leu Ala Arg Lys Asp Lys Arg Val Leu Arg Lys Lys Tyr Gln Ile 
        435                 440                 445             


Tyr Phe Trp Asn Ile Ala Thr Ile Ala Val Phe Tyr Ala Leu Pro Val 
    450                 455                 460                 


Val Gln Leu Val Ile Thr Tyr Gln Thr Val Val Asn Val Thr Gly Asn 
465                 470                 475                 480 


Gln Asp Ile Cys Tyr Tyr Asn Phe Leu Cys Ala His Pro Leu Gly Asn 
                485                 490                 495     


Leu Ser Ala Phe Asn Asn Ile Leu Ser Asn Leu Gly Tyr Ile Leu Leu 
            500                 505                 510         


Gly Leu Leu Phe Leu Leu Ile Ile Leu Gln Arg Glu Ile Asn His Asn 
        515                 520                 525             


Arg Ala Leu Leu Arg Asn Asp Leu Cys Ala Leu Glu Cys Gly Ile Pro 
    530                 535                 540                 


Lys His Phe Gly Leu Phe Tyr Ala Met Gly Thr Ala Leu Met Met Glu 
545                 550                 555                 560 


Gly Leu Leu Ser Ala Cys Tyr His Val Cys Pro Asn Tyr Thr Asn Phe 
                565                 570                 575     


Gln Phe Asp Thr Ser Phe Met Tyr Met Ile Ala Gly Leu Cys Met Leu 
            580                 585                 590         


Lys Leu Tyr Gln Lys Arg His Pro Asp Ile Asn Ala Ser Ala Tyr Ser 
        595                 600                 605             


Ala Tyr Ala Cys Leu Ala Ile Val Ile Phe Phe Ser Val Leu Gly Val 
    610                 615                 620                 


Val Phe Gly Lys Gly Asn Thr Ala Phe Trp Ile Val Phe Ser Ile Ile 
625                 630                 635                 640 


His Ile Ile Ala Thr Leu Leu Leu Ser Thr Gln Leu Tyr Tyr Met Gly 
                645                 650                 655     


Arg Trp Lys Leu Asp Ser Gly Ile Phe Arg Arg Ile Leu His Val Leu 
            660                 665                 670         


Tyr Thr Asp Cys Ile Arg Gln Cys Ser Gly Pro Leu Tyr Val Asp Arg 
        675                 680                 685             


Met Val Leu Leu Val Met Gly Asn Val Ile Asn Trp Ser Leu Ala Ala 
    690                 695                 700                 


Tyr Gly Leu Ile Met Arg Pro Asn Asp Phe Ala Ser Tyr Leu Leu Ala 
705                 710                 715                 720 


Ile Gly Ile Cys Asn Leu Leu Leu Tyr Phe Ala Phe Tyr Ile Ile Met 
                725                 730                 735     


Lys Leu Arg Ser Gly Glu Arg Ile Lys Leu Ile Pro Leu Leu Cys Ile 
            740                 745                 750         


Val Cys Thr Ser Val Val Trp Gly Phe Ala Leu Phe Phe Phe Phe Gln 
        755                 760                 765             


Gly Leu Ser Thr Trp Gln Lys Thr Pro Ala Glu Ser Arg Glu His Asn 
    770                 775                 780                 


Arg Asp Cys Ile Leu Leu Asp Phe Phe Asp Asp His Asp Ile Trp His 
785                 790                 795                 800 


Phe Leu Ser Ser Ile Ala Met Phe Gly Ser Phe Leu Val Leu Leu Thr 
                805                 810                 815     


Leu Asp Asp Asp Leu Asp Thr Val Gln Arg Asp Lys Ile Tyr Val Phe 
            820                 825                 830         


<210>  872
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  872

Met Ala Ala Ser Gly Pro Gly Cys Arg Ser Trp Cys Leu Cys Pro Glu 
1               5                   10                  15      


Val Pro Ser Ala Thr Phe Phe Thr Ala Leu Leu Ser Leu Leu Val Ser 
            20                  25                  30          


Gly Pro Arg Leu Phe Leu Leu Gln Gln Pro Leu Ala Pro Ser Gly Leu 
        35                  40                  45              


Thr Leu Lys Ser Glu Ala Leu Arg Asn Trp Gln Val Tyr Arg Leu Val 
    50                  55                  60                  


Thr Tyr Ile Phe Val Tyr Glu Asn Pro Ile Ser Leu Leu Cys Gly Ala 
65                  70                  75                  80  


Ile Ile Ile Trp Arg Phe Ala Gly Asn Phe Glu Arg Thr Val Gly Thr 
                85                  90                  95      


Val Arg His Cys Phe Phe Thr Val Ile Phe Ala Ile Phe Ser Ala Ile 
            100                 105                 110         


Ile Phe Leu Ser Phe Glu Ala Val Ser Ser Leu Ser Lys Leu Gly Glu 
        115                 120                 125             


Val Glu Asp Ala Arg Gly Phe Thr Pro Val Ala Phe Ala Met Leu Gly 
    130                 135                 140                 


Val Thr Thr Val Arg Ser Arg Met Arg Arg Ala Leu Val Phe Gly Met 
145                 150                 155                 160 


Val Val Pro Ser Val Leu Val Pro Trp Leu Leu Leu Gly Ala Ser Trp 
                165                 170                 175     


Leu Ile Pro Gln Thr Ser Phe Leu Ser Asn Val Cys Gly Leu Ser Ile 
            180                 185                 190         


Gly Leu Ala Tyr Gly Leu Thr Tyr Cys Tyr Ser Ile Asp Leu Ser Glu 
        195                 200                 205             


Arg Val Ala Leu Lys Leu Asp Gln Thr Phe Pro Phe Ser Leu Met Arg 
    210                 215                 220                 


Arg Ile Ser Val Phe Lys Tyr Val Ser Gly Ser Ser Ala Glu Arg Arg 
225                 230                 235                 240 


Ala Ala Gln Ser Arg Lys Leu Asn Pro Val Pro Gly Ser Tyr Pro Thr 
                245                 250                 255     


Gln Ser Cys His Pro His Leu Ser Pro Ser His Pro Val Ser Gln Thr 
            260                 265                 270         


Gln His Ala Ser Gly Gln Lys Leu Ala Ser Trp Pro Ser Cys Thr Pro 
        275                 280                 285             


Gly His Met Pro Thr Leu Pro Pro Tyr Gln Pro Ala Ser Gly Leu Cys 
    290                 295                 300                 


Tyr Val Gln Asn His Phe Gly Pro Asn Pro Thr Ser Ser Ser Val Tyr 
305                 310                 315                 320 


Pro Ala Ser Ala Gly Thr Ser Leu Gly Ile Gln Pro Pro Thr Pro Val 
                325                 330                 335     


Asn Ser Pro Gly Thr Val Tyr Ser Gly Ala Leu Gly Thr Pro Gly Ala 
            340                 345                 350         


Ala Gly Ser Lys Glu Ser Ser Arg Val Pro Met Pro 
        355                 360                 


<210>  873
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  873

Met Leu Gly Val Thr Thr Val Arg Ser Arg Met Arg Arg Ala Leu Val 
1               5                   10                  15      


Phe Gly Met Val Val Pro Ser Val Leu Val Pro Trp Leu Leu Leu Gly 
            20                  25                  30          


Ala Ser Trp Leu Ile Pro Gln Thr Ser Phe Leu Ser Asn Val Cys Gly 
        35                  40                  45              


Leu Ser Ile Gly Leu Ala Tyr Gly Leu Thr Tyr Cys Tyr Ser Ile Asp 
    50                  55                  60                  


Leu Ser Glu Arg Val Ala Leu Lys Leu Asp Gln Thr Phe Pro Phe Ser 
65                  70                  75                  80  


Leu Met Arg Arg Ile Ser Val Phe Lys Tyr Val Ser Gly Ser Ser Ala 
                85                  90                  95      


Glu Arg Arg Ala Ala Gln Ser Arg Lys Leu Asn Pro Val Pro Gly Ser 
            100                 105                 110         


Tyr Pro Thr Gln Ser Cys His Pro His Leu Ser Pro Ser His Pro Val 
        115                 120                 125             


Ser Gln Thr Gln His Ala Ser Gly Gln Lys Leu Ala Ser Trp Pro Ser 
    130                 135                 140                 


Cys Thr Pro Gly His Met Pro Thr Leu Pro Pro Tyr Gln Pro Ala Ser 
145                 150                 155                 160 


Gly Leu Cys Tyr Val Gln Asn His Phe Gly Pro Asn Pro Thr Ser Ser 
                165                 170                 175     


Ser Val Tyr Pro Ala Ser Ala Gly Thr Ser Leu Gly Ile Gln Pro Pro 
            180                 185                 190         


Thr Pro Val Asn Ser Pro Gly Thr Val Tyr Ser Gly Ala Leu Gly Thr 
        195                 200                 205             


Pro Gly Ala Ala Gly Ser Lys Glu Ser Ser Arg Val Pro Met Pro 
    210                 215                 220             


<210>  874
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  874

Met Ala Leu Met Leu Ser Leu Val Leu Ser Leu Leu Lys Leu Gly Ser 
1               5                   10                  15      


Gly Gln Trp Gln Val Phe Gly Pro Asp Lys Pro Val Gln Ala Leu Val 
            20                  25                  30          


Gly Glu Asp Ala Ala Phe Ser Cys Phe Leu Ser Pro Lys Thr Asn Ala 
        35                  40                  45              


Glu Ala Met Glu Val Arg Phe Phe Arg Gly Gln Phe Ser Ser Val Val 
    50                  55                  60                  


His Leu Tyr Arg Asp Gly Lys Asp Gln Pro Phe Met Gln Met Pro Gln 
65                  70                  75                  80  


Tyr Gln Gly Arg Thr Lys Leu Val Lys Asp Ser Ile Ala Glu Gly Arg 
                85                  90                  95      


Ile Ser Leu Arg Leu Glu Asn Ile Thr Val Leu Asp Ala Gly Leu Tyr 
            100                 105                 110         


Gly Cys Arg Ile Ser Ser Gln Ser Tyr Tyr Gln Lys Ala Ile Trp Glu 
        115                 120                 125             


Leu Gln Val Ser Ala Leu Gly Ser Val Pro Leu Ile Ser Ile Thr Gly 
    130                 135                 140                 


Tyr Val Asp Arg Asp Ile Gln Leu Leu Cys Gln Ser Ser Gly Trp Phe 
145                 150                 155                 160 


Pro Arg Pro Thr Ala Lys Trp Lys Gly Pro Gln Gly Gln Asp Leu Ser 
                165                 170                 175     


Thr Asp Ser Arg Thr Asn Arg Asp Met His Gly Leu Phe Asp Val Glu 
            180                 185                 190         


Ile Ser Leu Thr Val Gln Glu Asn Ala Gly Ser Ile Ser Cys Ser Met 
        195                 200                 205             


Arg His Ala His Leu Ser Arg Glu Val Glu Ser Arg Val Gln Ile Gly 
    210                 215                 220                 


Asp Thr Phe Phe Glu Pro Ile Ser Trp His Leu Ala Thr Lys Val Leu 
225                 230                 235                 240 


Gly Ile Leu Cys Cys Gly Leu Phe Phe Gly Ile Val Gly Leu Lys Ile 
                245                 250                 255     


Phe Phe Ser Lys Phe Gln Trp Lys Ile Gln Ala Glu Leu Asp Trp Arg 
            260                 265                 270         


Arg Lys His Gly Gln Ala Glu Leu Arg Asp Ala Arg Lys His Ala Val 
        275                 280                 285             


Glu Val Thr Leu Asp Pro Glu Thr Ala His Pro Lys Leu Cys Val Ser 
    290                 295                 300                 


Asp Leu Lys Thr Val Thr His Arg Lys Ala Pro Gln Glu Val Pro His 
305                 310                 315                 320 


Ser Glu Lys Arg Phe Thr Arg Lys Ser Val Val Ala Ser Gln Ser Phe 
                325                 330                 335     


Gln Ala Gly Lys His Tyr Trp Glu Val Asp Gly Gly His Asn Lys Arg 
            340                 345                 350         


Trp Arg Val Gly Val Cys Arg Asp Asp Val Asp Arg Arg Lys Glu Tyr 
        355                 360                 365             


Val Thr Leu Ser Pro Asp His Gly Tyr Trp Val Leu Arg Leu Asn Gly 
    370                 375                 380                 


Glu His Leu Tyr Phe Thr Leu Asn Pro Arg Phe Ile Ser Val Phe Pro 
385                 390                 395                 400 


Arg Thr Pro Pro Thr Lys Ile Gly Val Phe Leu Asp Tyr Glu Cys Gly 
                405                 410                 415     


Thr Ile Ser Phe Phe Asn Ile Asn Asp Gln Ser Leu Ile Tyr Thr Leu 
            420                 425                 430         


Thr Cys Arg Phe Glu Gly Leu Leu Arg Pro Tyr Ile Glu Tyr Pro Ser 
        435                 440                 445             


Tyr Asn Glu Gln Asn Gly Thr Pro Ile Val Ile Cys Pro Val Thr Gln 
    450                 455                 460                 


Glu Ser Glu Lys Glu Ala Ser Trp Gln Arg Ala Ser Ala Ile Pro Glu 
465                 470                 475                 480 


Thr Ser Asn Ser Glu Ser Ser Ser Gln Ala Thr Thr Pro Phe Leu Pro 
                485                 490                 495     


Arg Gly Glu Met 
            500 


<210>  875
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  875

Met Leu Phe Leu Ala Leu Gly Ser Pro Trp Ala Val Glu Leu Pro Leu 
1               5                   10                  15      


Cys Gly Arg Arg Thr Ala Leu Cys Ala Ala Ala Ala Leu Arg Gly Pro 
            20                  25                  30          


Arg Ala Ser Val Ser Arg Ala Ser Ser Ser Ser Gly Pro Ser Gly Pro 
        35                  40                  45              


Val Ala Gly Trp Ser Thr Gly Pro Ser Gly Ala Ala Arg Leu Leu Arg 
    50                  55                  60                  


Arg Pro Gly Arg Ala Gln Ile Pro Val Tyr Trp Glu Gly Tyr Val Arg 
65                  70                  75                  80  


Phe Leu Asn Thr Pro Ser Asp Lys Ser Glu Asp Gly Arg Leu Ile Tyr 
                85                  90                  95      


Thr Gly Asn Met Ala Arg Ala Val Phe Gly Lys 
            100                 105         


<210>  876
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  876

Met Ala Glu Gln Ala Thr Lys Ser Val Leu Phe Val Cys Leu Gly Asn 
1               5                   10                  15      


Ile Cys Arg Ser Pro Ile Ala Glu Ala Val Phe Arg Lys Leu Val Thr 
            20                  25                  30          


Asp Gln Asn Ile Ser Glu Asn Trp Arg Val Asp Ser Ala Ala Thr Ser 
        35                  40                  45              


Gly Tyr Glu Ile Gly Asn Pro Pro Asp Tyr Arg Gly Gln Ser Cys Met 
    50                  55                  60                  


Lys Arg His Gly Ile Pro Met Ser His Val Ala Arg Gln Val Pro Ser 
65                  70                  75                  80  


Leu Asp Leu Lys Leu Cys Val Leu Cys Phe Ser Gly Ser Leu Thr Ala 
                85                  90                  95      


Val Leu Phe Leu Thr Gly Thr Trp Ala Gly Pro Gln Thr Gln Glu Leu 
            100                 105                 110         


<210>  877
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  877

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Thr Ala Asp Thr Gln 
                85                  90                  95      


Ala Leu Leu Arg Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp 
            100                 105                 110         


Asp Ala Gln Tyr Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
        115                 120                 125         


<210>  878
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  878

Met Gly Ser Val Gly Ser Gln Arg Leu Glu Glu Pro Ser Val Ala Gly 
1               5                   10                  15      


Thr Pro Asp Pro Gly Val Val Met Ser Phe Thr Phe Asp Ser His Gln 
            20                  25                  30          


Leu Glu Glu Ala Ala Glu Ala Ala Gln Gly Gln Gly Leu Arg Ala Arg 
        35                  40                  45              


Gly Val Pro Ala Phe Thr Asp Thr Thr Leu Asp Glu Pro Val Pro Asp 
    50                  55                  60                  


Asp Arg Tyr His Ala Ile Tyr Phe Ala Met Leu Leu Ala Gly Val Gly 
65                  70                  75                  80  


Phe Leu Leu Pro Tyr Asn Ser Phe Ile Thr Asp Val Asp Tyr Leu His 
                85                  90                  95      


His Lys Tyr Pro Gly Thr Ser Ile Val Phe Asp Met Ser Leu Thr Tyr 
            100                 105                 110         


Ile Leu Val Ala Leu Ala Ala Val Leu Leu Asn Asn Val Leu Val Glu 
        115                 120                 125             


Arg Leu Thr Leu His Thr Arg Ile Thr Ala Gly Tyr Leu Leu Ala Leu 
    130                 135                 140                 


Gly Pro Leu Leu Phe Ile Ser Ile Cys Asp Val Trp Leu Gln Leu Phe 
145                 150                 155                 160 


Ser Arg Asp Gln Ala Tyr Ala Ile Asn Leu Ala Ala Val Gly Thr Val 
                165                 170                 175     


Ala Phe Gly Cys Thr Val Gln Gln Ser Ser Phe Tyr Gly Tyr Thr Gly 
            180                 185                 190         


Met Leu Pro Lys Arg Tyr Thr Gln Gly Val Met Thr Gly Glu Ser Thr 
        195                 200                 205             


Ala Gly Val Met Ile Ser Leu Ser Arg Ile Leu Thr Lys Leu Leu Leu 
    210                 215                 220                 


Pro Asp Glu Arg Ala Ser Thr Leu Ile Phe Phe Leu Val Ser Val Ala 
225                 230                 235                 240 


Leu Glu Leu Leu Cys Phe Leu Leu His Leu Leu Val Arg Arg Ser Arg 
                245                 250                 255     


Phe Val Leu Phe Tyr Thr Thr Arg Pro Arg Asp Ser His Arg Gly Arg 
            260                 265                 270         


Pro Gly Leu Gly Arg Gly Tyr Gly Tyr Arg Val His His Asp Val Val 
        275                 280                 285             


Ala Gly Asp Val His Phe Glu His Pro Ala Pro Ala Leu Ala Pro Asn 
    290                 295                 300                 


Glu Ser Pro Lys Asp Ser Pro Ala His Glu Val Thr Gly Ser Gly Gly 
305                 310                 315                 320 


Ala Tyr Met Arg Phe Asp Val Pro Arg Pro Arg Val Gln Arg Ser Trp 
                325                 330                 335     


Pro Thr Phe Arg Ala Leu Leu Leu His Arg Tyr Val Val Ala Arg Val 
            340                 345                 350         


Ile Trp Ala Asp Met Leu Ser Ile Ala Val Thr Tyr Phe Ile Thr Leu 
        355                 360                 365             


Cys Leu Phe Pro Gly Leu Glu Ser Glu Ile Arg His Cys Ile Leu Gly 
    370                 375                 380                 


Glu Trp Leu Pro Ile Leu Ile Met Ala Val Phe Asn Leu Ser Asp Phe 
385                 390                 395                 400 


Val Gly Lys Ile Leu Ala Ala Leu Pro Val Asp Trp Arg Gly Thr His 
                405                 410                 415     


Leu Leu Ala Cys Ser Cys Leu Arg Val Val Phe Ile Pro Leu Phe Ile 
            420                 425                 430         


Leu Cys Val Tyr Pro Ser Gly Met Pro Ala Leu Arg His Pro Ala Trp 
        435                 440                 445             


Pro Cys Ile Phe Ser Leu Leu Met Gly Ile Ser Asn Gly Tyr Phe Gly 
    450                 455                 460                 


Ser Val Pro Met Ile Leu Ala Ala Gly Lys Val Ser Pro Lys Gln Arg 
465                 470                 475                 480 


Glu Leu Ala Gly Asn Thr Met Thr Val Ser Tyr Met Ser Gly Leu Thr 
                485                 490                 495     


Leu Gly Ser Ala Val Ala Tyr Cys Thr Tyr Ser Leu Thr Arg Asp Ala 
            500                 505                 510         


His Gly Ser Cys Leu His Ala Ser Thr Ala Asn Gly Ser Ile Leu Ala 
        515                 520                 525             


Gly Leu 
    530 


<210>  879
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  879

Met Glu Ser Ile Ser Met Met Gly Ser Pro Lys Ser Leu Ser Glu Thr 
1               5                   10                  15      


Phe Leu Pro Asn Gly Ile Asn Gly Ile Lys Asp Ala Arg Lys Val Thr 
            20                  25                  30          


Val Gly Val Ile Gly Ser Gly Asp Phe Ala Lys Ser Leu Thr Ile Arg 
        35                  40                  45              


Leu Ile Arg Cys Gly Tyr His Val Val Ile Gly Ser Arg Asn Pro Lys 
    50                  55                  60                  


Phe Ala Ser Glu Phe Phe Pro His Val Val Asp Val Thr His His Glu 
65                  70                  75                  80  


Asp Ala Leu Thr Lys Thr Asn Ile Ile Phe Val Ala Ile His Arg Glu 
                85                  90                  95      


His Tyr Thr Ser Leu Trp Asp Leu Arg His Leu Leu Val Gly Lys Ile 
            100                 105                 110         


Leu Ile Asp Val Ser Asn Asn Met Arg Ile Asn Gln Tyr Pro Glu Ser 
        115                 120                 125             


Asn Ala Glu Tyr Leu Ala Ser Leu Phe Pro Asp Ser Leu Ile Val Lys 
    130                 135                 140                 


Gly Phe Asn Val Val Ser Ala Trp Ala Leu Gln Leu Gly Pro Lys Asp 
145                 150                 155                 160 


Ala Ser Arg Gln Val Tyr Ile Cys Ser Asn Asn Ile Gln Ala Arg Gln 
                165                 170                 175     


Gln Val Ile Glu Leu Ala Arg Gln Leu Asn Phe Ile Pro Ile Asp Leu 
            180                 185                 190         


Gly Ser Leu Ser Ser Ala Arg Glu Ile Glu Asn Leu Pro Leu Arg Leu 
        195                 200                 205             


Phe Thr Leu Trp Arg Gly Pro Val Val Val Ala Ile Ser Leu Ala Thr 
    210                 215                 220                 


Phe Phe Phe Leu Tyr Ser Phe Val Arg Asp Val Ile His Pro Tyr Ala 
225                 230                 235                 240 


Arg Asn Gln Gln Ser Asp Phe Tyr Lys Ile Pro Ile Glu Ile Val Asn 
                245                 250                 255     


Lys Thr Leu Pro Ile Val Ala Ile Thr Leu Leu Ser Leu Val Tyr Leu 
            260                 265                 270         


Ala Gly Leu Leu Ala Ala Ala Tyr Gln Leu Tyr Tyr Gly Thr Lys Tyr 
        275                 280                 285             


Arg Arg Phe Pro Pro Trp Leu Glu Thr Trp Leu Gln Cys Arg Lys Gln 
    290                 295                 300                 


Leu Gly Leu Leu Ser Phe Phe Phe Ala Met Val His Val Ala Tyr Ser 
305                 310                 315                 320 


Leu Cys Leu Pro Met Arg Arg Ser Glu Arg Tyr Leu Phe Leu Asn Met 
                325                 330                 335     


Ala Tyr Gln Gln Val His Ala Asn Ile Glu Asn Ser Trp Asn Glu Glu 
            340                 345                 350         


Glu Val Trp Arg Ile Glu Met Tyr Ile Ser Phe Gly Ile Met Ser Leu 
        355                 360                 365             


Gly Leu Leu Ser Leu Leu Ala Val Thr Ser Ile Pro Ser Val Ser Asn 
    370                 375                 380                 


Ala Leu Asn Trp Arg Glu Phe Ser Phe Ile Gln Ser Thr Leu Gly Tyr 
385                 390                 395                 400 


Val Ala Leu Leu Ile Ser Thr Phe His Val Leu Ile Tyr Gly Trp Lys 
                405                 410                 415     


Arg Ala Phe Glu Glu Glu Tyr Tyr Arg Phe Tyr Thr Pro Pro Asn Phe 
            420                 425                 430         


Val Leu Ala Leu Val Leu Pro Ser Ile Val Ile Leu Gly Lys Ile Ile 
        435                 440                 445             


Leu Phe Leu Pro Cys Ile Ser Arg Lys Leu Lys Arg Ile Lys Lys Gly 
    450                 455                 460                 


Trp Glu Lys Ser Gln Phe Leu Glu Glu Gly Met Gly Gly Thr Ile Pro 
465                 470                 475                 480 


His Val Ser Pro Glu Arg Val Thr Val Met 
                485                 490 


<210>  880
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  880

Met Glu Ser Ile Ser Met Met Gly Ser Pro Lys Ser Leu Ser Glu Thr 
1               5                   10                  15      


Phe Leu Pro Asn Gly Ile Asn Gly Ile Lys Asp Ala Arg Lys Val Thr 
            20                  25                  30          


Val Gly Val Ile Gly Ser Gly Asp Phe Ala Lys Ser Leu Thr Ile Arg 
        35                  40                  45              


Leu Ile Arg Cys Gly Tyr His Val Val Ile Gly Ser Arg Asn Pro Lys 
    50                  55                  60                  


Phe Ala Ser Glu Phe Phe Pro His Val Val Asp Val Thr His His Glu 
65                  70                  75                  80  


Asp Ala Leu Thr Lys Thr Asn Ile Ile Phe Val Ala Ile His Arg Glu 
                85                  90                  95      


His Tyr Thr Ser Leu Trp Asp Leu Arg His Leu Leu Val Gly Lys Ile 
            100                 105                 110         


Leu Ile Asp Val Ser Asn Asn Met Arg Ile Asn Gln Tyr Pro Glu Ser 
        115                 120                 125             


Asn Ala Glu Tyr Leu Ala Ser Leu Phe Pro Asp Ser Leu Ile Val Lys 
    130                 135                 140                 


Gly Phe Asn Val Val Ser Ala Trp Ala Leu Gln Leu Gly Pro Lys Asp 
145                 150                 155                 160 


Ala Ser Arg Gln Val Tyr Ile Cys Ser Asn Asn Ile Gln Ala Arg Gln 
                165                 170                 175     


Gln Val Ile Glu Leu Ala Arg Gln Leu Asn Phe Ile Pro Ile Asp Leu 
            180                 185                 190         


Gly Ser Leu Ser Ser Ala Arg Glu Ile Glu Asn Leu Pro Leu Arg Leu 
        195                 200                 205             


Phe Thr Leu Trp Arg Gly Pro Val Val Val Ala Ile Ser Leu Ala Thr 
    210                 215                 220                 


Phe Phe Phe Leu Tyr Ser Phe Val Arg Asp Val Ile His Pro Tyr Ala 
225                 230                 235                 240 


Arg Asn Gln Gln Ser Asp Phe Tyr Lys Ile Pro Ile Glu Ile Val Asn 
                245                 250                 255     


Lys Thr Leu Pro Ile Val Ala Ile Thr Leu Leu Ser Leu Val Tyr Leu 
            260                 265                 270         


Ala Gly Leu Leu Ala Ala Ala Tyr Gln Leu Tyr Tyr Gly Thr Lys Tyr 
        275                 280                 285             


Arg Arg Phe Pro Pro Trp Leu Glu Thr Trp Leu Gln Cys Arg Lys Gln 
    290                 295                 300                 


Leu Gly Leu Leu Ser Phe Phe Phe Ala Met Val His Val Ala Tyr Ser 
305                 310                 315                 320 


Leu Cys Leu Pro Met Arg Arg Ser Glu Arg Tyr Leu Phe Leu Asn Met 
                325                 330                 335     


Ala Tyr Gln Gln Val His Ala Asn Ile Glu Asn Ser Trp Asn Glu Glu 
            340                 345                 350         


Glu Val Trp Arg Ile Glu Met Tyr Ile Ser Phe Gly Ile Met Ser Leu 
        355                 360                 365             


Gly Leu Leu Ser Leu Leu Ala Val Thr Ser Ile Pro Ser Val Ser Asn 
    370                 375                 380                 


Ala Leu Asn Trp Arg Glu Phe Ser Phe Ile Gln Ser Thr Leu Gly Tyr 
385                 390                 395                 400 


Val Ala Leu Leu Ile Ser Thr Phe His Val Leu Ile Tyr Gly Trp Lys 
                405                 410                 415     


Arg Ala Phe Glu Glu Glu Tyr Tyr Arg Phe Tyr Thr Pro Pro Asn Phe 
            420                 425                 430         


Val Leu Ala Leu Val Leu Pro Ser Ile Val Ile Leu Asp Leu Leu Gln 
        435                 440                 445             


Leu Cys Arg Tyr Pro Asp 
    450                 


<210>  881
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  881

Met Asp Pro Leu Gly Pro Ala Lys Pro Gln Trp Ser Trp Arg Cys Cys 
1               5                   10                  15      


Leu Thr Thr Leu Leu Phe Gln Leu Leu Met Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Gln Asp Asp Pro Thr Val Tyr Pro Asn Gly Ser 
        35                  40                  45              


Arg Phe Pro Asp Ser Thr Gly Thr Pro Ala His Ser Ile Pro Leu Ile 
    50                  55                  60                  


Leu Leu Trp Thr Trp Pro Phe Asn Lys Pro Ile Ala Leu Pro Arg Cys 
65                  70                  75                  80  


Ser Glu Met Val Pro Gly Thr Ala Asp Cys Asn Ile Thr Ala Asp Arg 
                85                  90                  95      


Lys Val Tyr Pro Gln Ala Asp Ala Val Ile Val His His Arg Glu Val 
            100                 105                 110         


Met Tyr Asn Pro Ser Ala Gln Leu Pro Arg Ser Pro Arg Arg Gln Gly 
        115                 120                 125             


Gln Arg Trp Ile Trp Phe Ser Met Glu Ser Pro Ser His Cys Trp Gln 
    130                 135                 140                 


Leu Lys Ala Met Asp Gly Tyr Phe Asn Leu Thr Met Ser Tyr Arg Ser 
145                 150                 155                 160 


Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser Gly 
                165                 170                 175     


Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu Val 
            180                 185                 190         


Ala Trp Ala Val Ser Asn Trp Gly Pro Asn Ser Ala Arg Val Arg Tyr 
        195                 200                 205             


Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg Ser 
    210                 215                 220                 


His Lys Pro Leu Pro Gln Gly Thr Met Met Glu Thr Leu Ser Arg Tyr 
225                 230                 235                 240 


Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile Thr 
                245                 250                 255     


Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val Val 
            260                 265                 270         


Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp Ala 
        275                 280                 285             


Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg Tyr 
    290                 295                 300                 


Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe Arg 
305                 310                 315                 320 


Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Ala Phe 
                325                 330                 335     


Cys Lys Ala Cys Trp Lys Leu Gln Glu Glu Ser Arg Tyr Gln Thr Arg 
            340                 345                 350         


Gly Ile Ala Ala Trp Phe Thr 
        355                 


<210>  882
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  882

Met Ser Ser Thr Glu Ser Ala Gly Arg Thr Ala Asp Lys Ser Pro Arg 
1               5                   10                  15      


Gln Gln Val Asp Arg Leu Leu Val Gly Leu Arg Trp Arg Arg Leu Glu 
            20                  25                  30          


Glu Pro Leu Gly Phe Ile Lys Val Leu Gln Trp Leu Phe Ala Ile Phe 
        35                  40                  45              


Ala Phe Gly Ser Cys Gly Ser Tyr Ser Gly Glu Thr Gly Ala Met Val 
    50                  55                  60                  


Arg Cys Asn Asn Glu Ala Lys Asp Val Ser Ser Ile Ile Val Ala Phe 
65                  70                  75                  80  


Gly Tyr Pro Phe Arg Leu His Arg Ile Gln Tyr Glu Met Pro Leu Cys 
                85                  90                  95      


Asp Glu Glu Ser Ser Ser Lys Thr Met His Leu Met Gly Asp Phe Ser 
            100                 105                 110         


Ala Pro Ala Glu Phe Phe Val Thr Leu Gly Ile Phe Ser Phe Phe Tyr 
        115                 120                 125             


Thr Met Ala Ala Leu Val Ile Tyr Leu Arg Phe His Asn Leu Tyr Thr 
    130                 135                 140                 


Glu Asn Lys Arg Phe Pro Leu Val Asp Phe Cys Val Thr Val Ser Phe 
145                 150                 155                 160 


Thr Phe Phe Trp Leu Val Ala Ala Ala Ala Trp Gly Lys Gly Leu Thr 
                165                 170                 175     


Asp Val Lys Gly Ala Thr Arg Pro Ser Ser Leu Thr Ala Ala Met Ser 
            180                 185                 190         


Val Cys His Gly Glu Glu Ala Val Cys Ser Ala Gly Ala Thr Pro Ser 
        195                 200                 205             


Met Gly Leu Ala Asn Ile Ser Val Leu Phe Gly Phe Ile Asn Phe Phe 
    210                 215                 220                 


Leu Trp Ala Gly Asn Cys Trp Phe Val Phe Lys Glu Thr Pro Trp His 
225                 230                 235                 240 


Gly Gln Gly Gln Gly Gln Asp Gln Asp Gln Asp Gln Asp Gln Gly Gln 
                245                 250                 255     


Gly Pro Ser Gln Glu Ser Ala Ala Glu Gln Gly Ala Val Glu Lys Gln 
            260                 265                 270         


<210>  883
<211>  1502
<212>  PRT
<213>  Homo sapiens

<400>  883

Met Val His Val Ala Arg Leu Leu Leu Leu Leu Leu Thr Phe Phe Leu 
1               5                   10                  15      


Arg Thr Asp Ala Glu Thr Pro Pro Arg Phe Thr Arg Thr Pro Val Asp 
            20                  25                  30          


Gln Thr Gly Val Ser Gly Gly Val Ala Ser Phe Ile Cys Gln Ala Thr 
        35                  40                  45              


Gly Asp Pro Arg Pro Lys Ile Val Trp Asn Lys Lys Gly Lys Lys Val 
    50                  55                  60                  


Ser Asn Gln Arg Phe Glu Val Ile Glu Phe Asp Asp Gly Ser Gly Ser 
65                  70                  75                  80  


Val Leu Arg Ile Gln Pro Leu Arg Thr Pro Arg Asp Glu Ala Ile Tyr 
                85                  90                  95      


Glu Cys Val Ala Ser Asn Asn Val Gly Glu Ile Ser Val Ser Thr Arg 
            100                 105                 110         


Leu Thr Val Leu Arg Glu Asp Gln Ile Pro Arg Gly Phe Pro Thr Ile 
        115                 120                 125             


Asp Met Gly Pro Gln Leu Lys Val Val Glu Arg Thr Arg Thr Ala Thr 
    130                 135                 140                 


Met Leu Cys Ala Ala Ser Gly Asn Pro Asp Pro Glu Ile Thr Trp Phe 
145                 150                 155                 160 


Lys Asp Phe Leu Pro Val Asp Thr Ser Asn Asn Asn Gly Arg Ile Lys 
                165                 170                 175     


Gln Leu Arg Ser Gly Gly Thr Pro Ile Arg Gly Ala Leu Gln Ile Glu 
            180                 185                 190         


Gln Ser Glu Glu Ser Asp Gln Gly Lys Tyr Glu Cys Val Ala Thr Asn 
        195                 200                 205             


Ser Ala Gly Thr Arg Tyr Ser Ala Pro Ala Asn Leu Tyr Val Arg Glu 
    210                 215                 220                 


Leu Arg Glu Val Arg Arg Val Pro Pro Arg Phe Ser Ile Pro Pro Thr 
225                 230                 235                 240 


Asn His Glu Ile Met Pro Gly Gly Ser Val Asn Ile Thr Cys Val Ala 
                245                 250                 255     


Val Gly Ser Pro Met Pro Tyr Val Lys Trp Met Leu Gly Ala Glu Asp 
            260                 265                 270         


Leu Thr Pro Glu Asp Asp Met Pro Ile Gly Arg Asn Val Leu Glu Leu 
        275                 280                 285             


Asn Asp Val Arg Gln Ser Ala Asn Tyr Thr Cys Val Ala Met Ser Thr 
    290                 295                 300                 


Leu Gly Val Ile Glu Ala Ile Ala Gln Ile Thr Val Lys Ala Leu Pro 
305                 310                 315                 320 


Lys Pro Pro Gly Thr Pro Val Val Thr Glu Ser Thr Ala Thr Ser Ile 
                325                 330                 335     


Thr Leu Thr Trp Asp Ser Gly Asn Pro Glu Pro Val Ser Tyr Tyr Ile 
            340                 345                 350         


Ile Gln His Lys Pro Lys Asn Ser Glu Glu Leu Tyr Lys Glu Ile Asp 
        355                 360                 365             


Gly Val Ala Thr Thr Arg Tyr Ser Val Ala Gly Leu Ser Pro Tyr Ser 
    370                 375                 380                 


Asp Tyr Glu Phe Arg Val Val Ala Val Asn Asn Ile Gly Arg Gly Pro 
385                 390                 395                 400 


Pro Ser Glu Pro Val Leu Thr Gln Thr Ser Glu Gln Ala Pro Ser Ser 
                405                 410                 415     


Ala Pro Arg Asp Val Gln Ala Arg Met Leu Ser Ser Thr Thr Ile Leu 
            420                 425                 430         


Val Gln Trp Lys Glu Pro Glu Glu Pro Asn Gly Gln Ile Gln Gly Tyr 
        435                 440                 445             


Arg Val Tyr Tyr Thr Met Asp Pro Thr Gln His Val Asn Asn Trp Met 
    450                 455                 460                 


Lys His Asn Val Ala Asp Ser Gln Ile Thr Thr Ile Gly Asn Leu Val 
465                 470                 475                 480 


Pro Gln Lys Thr Tyr Ser Val Lys Val Leu Ala Phe Thr Ser Ile Gly 
                485                 490                 495     


Asp Gly Pro Leu Ser Ser Asp Ile Gln Val Ile Thr Gln Thr Gly Val 
            500                 505                 510         


Pro Gly Gln Pro Leu Asn Phe Lys Ala Glu Pro Glu Ser Glu Thr Ser 
        515                 520                 525             


Ile Leu Leu Ser Trp Thr Pro Pro Arg Ser Asp Thr Ile Ala Asn Tyr 
    530                 535                 540                 


Glu Leu Val Tyr Lys Asp Gly Glu His Gly Glu Glu Gln Arg Ile Thr 
545                 550                 555                 560 


Ile Glu Pro Gly Thr Ser Tyr Arg Leu Gln Gly Leu Lys Pro Asn Ser 
                565                 570                 575     


Leu Tyr Tyr Phe Arg Leu Ala Ala Arg Ser Pro Gln Gly Leu Gly Ala 
            580                 585                 590         


Ser Thr Ala Glu Ile Ser Ala Arg Thr Met Gln Ser Met Phe Ala Lys 
        595                 600                 605             


Asn Phe His Val Lys Ala Val Met Lys Thr Ser Val Leu Leu Ser Trp 
    610                 615                 620                 


Glu Ile Pro Glu Asn Tyr Asn Ser Ala Met Pro Phe Lys Ile Leu Tyr 
625                 630                 635                 640 


Asp Asp Gly Lys Met Val Glu Glu Val Asp Gly Arg Ala Thr Gln Lys 
                645                 650                 655     


Leu Ile Val Asn Leu Lys Pro Glu Lys Ser Tyr Ser Phe Val Leu Thr 
            660                 665                 670         


Asn Arg Gly Asn Ser Ala Gly Gly Leu Gln His Arg Val Thr Ala Lys 
        675                 680                 685             


Thr Ala Pro Asp Val Leu Arg Thr Lys Pro Ala Phe Ile Gly Lys Thr 
    690                 695                 700                 


Asn Leu Asp Gly Met Ile Thr Val Gln Leu Pro Glu Val Pro Ala Asn 
705                 710                 715                 720 


Glu Asn Ile Lys Gly Tyr Tyr Ile Ile Ile Val Pro Leu Lys Lys Ser 
                725                 730                 735     


Arg Gly Lys Phe Ile Lys Pro Trp Glu Ser Pro Asp Glu Met Glu Leu 
            740                 745                 750         


Asp Glu Leu Leu Lys Glu Ile Ser Arg Lys Arg Arg Ser Ile Arg Tyr 
        755                 760                 765             


Gly Arg Glu Val Glu Leu Lys Pro Tyr Ile Ala Ala His Phe Asp Val 
    770                 775                 780                 


Leu Pro Thr Glu Phe Thr Leu Gly Asp Asp Lys His Tyr Gly Gly Phe 
785                 790                 795                 800 


Thr Asn Lys Gln Leu Gln Ser Gly Gln Glu Tyr Val Phe Phe Val Leu 
                805                 810                 815     


Ala Val Met Glu His Ala Glu Ser Lys Met Tyr Ala Thr Ser Pro Tyr 
            820                 825                 830         


Ser Asp Pro Val Val Ser Met Asp Leu Asp Pro Gln Pro Ile Thr Asp 
        835                 840                 845             


Glu Glu Glu Gly Leu Ile Trp Val Val Gly Pro Val Leu Ala Val Val 
    850                 855                 860                 


Phe Ile Ile Cys Ile Val Ile Ala Ile Leu Leu Tyr Lys Ser Lys Pro 
865                 870                 875                 880 


Asp Arg Lys Arg Ala Glu Ser Asp Ser Arg Lys Ser Ser Ile Pro Asn 
                885                 890                 895     


Asn Lys Glu Ile Pro Ser His His Pro Thr Asp Pro Val Glu Leu Arg 
            900                 905                 910         


Arg Leu Asn Phe Gln Thr Pro Gly Met Ala Ser His Pro Pro Ile Pro 
        915                 920                 925             


Ile Leu Glu Leu Ala Asp His Ile Glu Arg Leu Lys Ala Asn Asp Asn 
    930                 935                 940                 


Leu Lys Phe Ser Gln Glu Tyr Glu Ser Ile Asp Pro Gly Gln Gln Phe 
945                 950                 955                 960 


Thr Trp Glu His Ser Asn Leu Glu Val Asn Lys Pro Lys Asn Arg Tyr 
                965                 970                 975     


Ala Asn Val Ile Ala Tyr Asp His Ser Arg Val Leu Leu Ser Ala Ile 
            980                 985                 990         


Glu Gly Ile Pro Gly Ser Asp Tyr  Val Asn Ala Asn Tyr  Ile Asp Gly 
        995                 1000                 1005             


Tyr Arg  Lys Gln Asn Ala Tyr  Ile Ala Thr Gln Gly  Ser Leu Pro 
    1010                 1015                 1020             


Glu Thr  Phe Gly Asp Phe Trp  Arg Met Ile Trp Glu  Gln Arg Ser 
    1025                 1030                 1035             


Ala Thr  Val Val Met Met Thr  Lys Leu Glu Glu Arg  Ser Arg Val 
    1040                 1045                 1050             


Lys Cys  Asp Gln Tyr Trp Pro  Ser Arg Gly Thr Glu  Thr His Gly 
    1055                 1060                 1065             


Leu Val  Gln Val Thr Leu Leu  Asp Thr Val Glu Leu  Ala Thr Tyr 
    1070                 1075                 1080             


Cys Val  Arg Thr Phe Ala Leu  Tyr Lys Asn Gly Ser  Ser Glu Lys 
    1085                 1090                 1095             


Arg Glu  Val Arg Gln Phe Gln  Phe Thr Ala Trp Pro  Asp His Gly 
    1100                 1105                 1110             


Val Pro  Glu His Pro Thr Pro  Phe Leu Ala Phe Leu  Arg Arg Val 
    1115                 1120                 1125             


Lys Thr  Cys Asn Pro Pro Asp  Ala Gly Pro Met Val  Val His Cys 
    1130                 1135                 1140             


Ser Ala  Gly Val Gly Arg Thr  Gly Cys Phe Ile Val  Ile Asp Ala 
    1145                 1150                 1155             


Met Leu  Glu Arg Ile Lys His  Glu Lys Thr Val Asp  Ile Tyr Gly 
    1160                 1165                 1170             


His Val  Thr Leu Met Arg Ala  Gln Arg Asn Tyr Met  Val Gln Thr 
    1175                 1180                 1185             


Glu Asp  Gln Tyr Ile Phe Ile  His Asp Ala Leu Leu  Glu Ala Val 
    1190                 1195                 1200             


Thr Cys  Gly Asn Thr Glu Val  Pro Ala Arg Asn Leu  Tyr Ala Tyr 
    1205                 1210                 1215             


Ile Gln  Lys Leu Thr Gln Ile  Glu Thr Gly Glu Asn  Val Thr Gly 
    1220                 1225                 1230             


Met Glu  Leu Glu Phe Lys Arg  Leu Ala Ser Ser Lys  Ala His Thr 
    1235                 1240                 1245             


Ser Arg  Phe Ile Ser Ala Asn  Leu Pro Cys Asn Lys  Phe Lys Asn 
    1250                 1255                 1260             


Arg Leu  Val Asn Ile Met Pro  Tyr Glu Ser Thr Arg  Val Cys Leu 
    1265                 1270                 1275             


Gln Pro  Ile Arg Gly Val Glu  Gly Ser Asp Tyr Ile  Asn Ala Ser 
    1280                 1285                 1290             


Phe Ile  Asp Gly Tyr Arg Gln  Gln Lys Ala Tyr Ile  Ala Thr Gln 
    1295                 1300                 1305             


Gly Pro  Leu Ala Glu Thr Thr  Glu Asp Phe Trp Arg  Met Leu Trp 
    1310                 1315                 1320             


Glu His  Asn Ser Thr Ile Val  Val Met Leu Thr Lys  Leu Arg Glu 
    1325                 1330                 1335             


Met Gly  Arg Glu Lys Cys His  Gln Tyr Trp Pro Ala  Glu Arg Ser 
    1340                 1345                 1350             


Ala Arg  Tyr Gln Tyr Phe Val  Val Asp Pro Met Ala  Glu Tyr Asn 
    1355                 1360                 1365             


Met Pro  Gln Tyr Ile Leu Arg  Glu Phe Lys Val Thr  Asp Ala Arg 
    1370                 1375                 1380             


Asp Gly  Gln Ser Arg Thr Val  Arg Gln Phe Gln Phe  Thr Asp Trp 
    1385                 1390                 1395             


Pro Glu  Gln Gly Val Pro Lys  Ser Gly Glu Gly Phe  Ile Asp Phe 
    1400                 1405                 1410             


Ile Gly  Gln Val His Lys Thr  Lys Glu Gln Phe Gly  Gln Asp Gly 
    1415                 1420                 1425             


Pro Ile  Ser Val His Cys Ser  Ala Gly Val Gly Arg  Thr Gly Val 
    1430                 1435                 1440             


Phe Ile  Thr Leu Ser Ile Val  Leu Glu Arg Met Arg  Tyr Glu Gly 
    1445                 1450                 1455             


Val Val  Asp Ile Phe Gln Thr  Val Lys Met Leu Arg  Thr Gln Arg 
    1460                 1465                 1470             


Pro Ala  Met Val Gln Thr Glu  Asp Gln Tyr Gln Phe  Ser Tyr Arg 
    1475                 1480                 1485             


Ala Ala  Leu Glu Tyr Leu Gly  Ser Phe Asp His Tyr  Ala Thr 
    1490                 1495                 1500         


<210>  884
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  884

Met Arg Leu Asn Ser Thr Gly Glu Val Pro Val Leu Ile His Gly Glu 
1               5                   10                  15      


Asn Ile Ile Cys Glu Ala Thr Gln Ile Ile Asp Tyr Leu Glu Gln Thr 
            20                  25                  30          


Phe Leu Asp Glu Arg Thr Pro Arg Leu Met Pro Asp Lys Glu Ser Met 
        35                  40                  45              


Tyr Tyr Pro Arg Val Gln His Tyr Arg Glu Leu Leu Asp Ser Leu Pro 
    50                  55                  60                  


Met Asp Ala Tyr Thr His Gly Cys Ile Leu His Pro Glu Leu Thr Val 
65                  70                  75                  80  


Asp Ser Met Ile Pro Ala Tyr Ala Thr Thr Arg Ile Arg Ser Gln Ile 
                85                  90                  95      


Gly Asn Thr Glu Ser Glu Leu Lys Lys Leu Ala Glu Glu Asn Pro Asp 
            100                 105                 110         


Leu Gln Glu Ala Tyr Ile Ala Lys Gln Lys Arg Leu Lys Ser Lys Leu 
        115                 120                 125             


Leu Asp His Asp Asn Val Lys Tyr Leu Lys Lys Ile Leu Asp Glu Leu 
    130                 135                 140                 


Glu Lys Val Leu Asp Gln Val Glu Thr Glu Leu Gln Arg Arg Asn Glu 
145                 150                 155                 160 


Glu Thr Pro Glu Glu Gly Gln Gln Pro Trp Leu Cys Gly Glu Ser Phe 
                165                 170                 175     


Thr Leu Ala Asp Val Ser Leu Ala Val Thr Leu His Arg Leu Lys Phe 
            180                 185                 190         


Leu Gly Phe Ala Arg Arg Asn Trp Gly Asn Gly Lys Arg Pro Asn Leu 
        195                 200                 205             


Glu Thr Tyr Tyr Glu Arg Val Leu Lys Arg Lys Thr Phe Asn Lys Val 
    210                 215                 220                 


Leu Gly His Val Asn Asn Ile Leu Ile Ser Ala Val Leu Pro Thr Ala 
225                 230                 235                 240 


Phe Arg Val Ala Lys Lys Arg Ala Pro Lys Val Leu Gly Thr Thr Leu 
                245                 250                 255     


Val Val Gly Leu Leu Ala Gly Val Gly Tyr Phe Ala Phe Met Leu Phe 
            260                 265                 270         


Arg Lys Arg Leu Gly Ser Met Ile Leu Ala Phe Arg Pro Arg Pro Asn 
        275                 280                 285             


Tyr Phe 
    290 


<210>  885
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  885

Met Arg Thr Ala Asp Arg Glu Ala Arg Pro Gly Leu Pro Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ala Gly Ala Gly Leu Ser Ala Ala Ser Pro Pro Ala 
            20                  25                  30          


Ala Pro Arg Phe Asn Val Ser Leu Asp Ser Val Pro Glu Leu Arg Trp 
        35                  40                  45              


Leu Pro Val Leu Arg His Tyr Asp Leu Asp Leu Val Arg Ala Ala Met 
    50                  55                  60                  


Ala Gln Val Ile Gly Asp Arg Val Pro Lys Trp Val His Val Leu Ile 
65                  70                  75                  80  


Gly Lys Val Val Leu Glu Leu Glu Arg Phe Leu Pro Gln Pro Phe Thr 
                85                  90                  95      


Gly Glu Ile Arg Gly Met Cys Asp Phe Met Asn Leu Ser Leu Ala Asp 
            100                 105                 110         


Cys Leu Leu Val Asn Leu Ala Tyr Glu Ser Ser Val Phe Cys Thr Ser 
        115                 120                 125             


Ile Val Ala Gln Asp Ser Arg Gly His Ile Tyr His Gly Arg Asn Leu 
    130                 135                 140                 


Asp Tyr Pro Phe Gly Asn Val Leu Arg Lys Leu Thr Val Asp Val Gln 
145                 150                 155                 160 


Phe Leu Lys Asn Gly Gln Ile Ala Phe Thr Gly Thr Thr Phe Ile Gly 
                165                 170                 175     


Tyr Val Gly Leu Trp Thr Gly Gln Ser Pro His Lys Phe Thr Val Ser 
            180                 185                 190         


Gly Asp Glu Arg Asp Lys Gly Trp Trp Trp Glu Asn Ala Ile Ala Ala 
        195                 200                 205             


Leu Phe Arg Arg His Ile Pro Val Ser Trp Leu Ile Arg Ala Thr Leu 
    210                 215                 220                 


Ser Glu Ser Glu Asn Phe Glu Ala Ala Val Gly Lys Leu Ala Lys Thr 
225                 230                 235                 240 


Pro Leu Ile Ala Asp Val Tyr Tyr Ile Val Gly Gly Thr Ser Pro Arg 
                245                 250                 255     


Glu Gly Val Val Ile Thr Arg Asn Arg Asp Gly Pro Ala Asp Ile Trp 
            260                 265                 270         


Pro Leu Asp Pro Leu Asn Gly Ala Trp Phe Arg Val Glu Thr Asn Tyr 
        275                 280                 285             


Asp His Trp Lys Pro Ala Pro Lys Glu Asp Asp Arg Arg Thr Ser Ala 
    290                 295                 300                 


Ile Lys Ala Leu Asn Ala Thr Gly Gln Ala Asn Leu Ser Leu Glu Ala 
305                 310                 315                 320 


Leu Phe Gln 
            


<210>  886
<211>  438
<212>  PRT
<213>  Homo sapiens

<400>  886

Met Gly Gly Cys Ala Gly Ser Arg Arg Arg Phe Ser Asp Ser Glu Gly 
1               5                   10                  15      


Glu Glu Thr Val Pro Glu Pro Arg Leu Pro Leu Leu Asp His Gln Gly 
            20                  25                  30          


Ala His Trp Lys Asn Ala Val Gly Phe Trp Leu Leu Gly Leu Cys Asn 
        35                  40                  45              


Asn Phe Ser Tyr Val Val Met Leu Ser Ala Ala His Asp Ile Leu Ser 
    50                  55                  60                  


His Lys Arg Thr Ser Gly Asn Gln Ser His Val Asp Pro Gly Pro Thr 
65                  70                  75                  80  


Pro Ile Pro His Asn Ser Ser Ser Arg Phe Asp Cys Asn Ser Val Ser 
                85                  90                  95      


Thr Ala Ala Val Leu Leu Ala Asp Ile Leu Pro Thr Leu Val Ile Lys 
            100                 105                 110         


Leu Leu Ala Pro Leu Gly Leu His Leu Leu Pro Tyr Ser Pro Arg Val 
        115                 120                 125             


Leu Val Ser Gly Ile Cys Ala Ala Gly Ser Phe Val Leu Val Ala Phe 
    130                 135                 140                 


Ser His Ser Val Gly Thr Ser Leu Cys Gly Val Val Phe Ala Ser Ile 
145                 150                 155                 160 


Ser Ser Gly Leu Gly Glu Val Thr Phe Leu Ser Leu Thr Ala Phe Tyr 
                165                 170                 175     


Pro Arg Ala Val Ile Ser Trp Trp Ser Ser Gly Thr Gly Gly Ala Gly 
            180                 185                 190         


Leu Leu Gly Ala Leu Ser Tyr Leu Gly Leu Thr Gln Ala Gly Leu Ser 
        195                 200                 205             


Pro Gln Gln Thr Leu Leu Ser Met Leu Gly Ile Pro Ala Leu Leu Leu 
    210                 215                 220                 


Ala Ser Tyr Phe Leu Leu Leu Thr Ser Pro Glu Ala Gln Asp Pro Gly 
225                 230                 235                 240 


Gly Glu Glu Glu Ala Glu Ser Ala Ala Arg Gln Pro Leu Ile Arg Thr 
                245                 250                 255     


Glu Ala Pro Glu Ser Lys Pro Gly Ser Ser Ser Ser Leu Ser Leu Arg 
            260                 265                 270         


Glu Arg Trp Thr Val Phe Lys Gly Leu Leu Trp Tyr Ile Val Pro Leu 
        275                 280                 285             


Val Val Val Tyr Phe Ala Glu Tyr Phe Ile Asn Gln Gly Leu Phe Glu 
    290                 295                 300                 


Leu Leu Phe Phe Trp Asn Thr Ser Leu Ser His Ala Gln Gln Tyr Arg 
305                 310                 315                 320 


Trp Tyr Gln Met Leu Tyr Gln Ala Gly Val Phe Ala Ser Arg Ser Ser 
                325                 330                 335     


Leu Arg Cys Cys Arg Ile Arg Phe Thr Trp Ala Leu Ala Leu Leu Gln 
            340                 345                 350         


Cys Leu Asn Leu Val Phe Leu Leu Ala Asp Val Trp Phe Gly Phe Leu 
        355                 360                 365             


Pro Ser Ile Tyr Leu Val Phe Leu Ile Ile Leu Tyr Glu Gly Leu Leu 
    370                 375                 380                 


Gly Gly Ala Ala Tyr Val Asn Thr Phe His Asn Ile Ala Leu Glu Thr 
385                 390                 395                 400 


Ser Asp Glu His Arg Glu Phe Ala Met Ala Ala Thr Cys Ile Ser Asp 
                405                 410                 415     


Thr Leu Gly Ile Ser Leu Ser Gly Leu Leu Ala Leu Pro Leu His Asp 
            420                 425                 430         


Phe Leu Cys Gln Leu Ser 
        435             


<210>  887
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  887

Met Ala Ser Val Pro Met Pro Ser Glu Tyr Thr Tyr Val Lys Leu Arg 
1               5                   10                  15      


Ser Asp Cys Ser Arg Pro Ser Leu Gln Trp Tyr Thr Arg Ala Gln Ser 
            20                  25                  30          


Lys Met Arg Arg Pro Ser Leu Leu Leu Lys Asp Ile Leu Lys Cys Thr 
        35                  40                  45              


Leu Leu Val Phe Gly Val Trp Ile Leu Tyr Ile Leu Lys Leu Asn Tyr 
    50                  55                  60                  


Thr Thr Glu Glu Cys Asp Met Lys Lys Met His Tyr Val Asp Pro Asp 
65                  70                  75                  80  


His Val Lys Arg Ala Gln Lys Tyr Ala Gln Gln Val Leu Gln Lys Glu 
                85                  90                  95      


Cys Arg Pro Lys Phe Ala Lys Thr Ser Met Ala Leu Leu Phe Glu His 
            100                 105                 110         


Arg Tyr Ser Val Asp Leu Leu Pro Phe Val Gln Lys Ala Pro Lys Asp 
        115                 120                 125             


Ser Glu Ala Glu Ser Lys Tyr Asp Pro Pro Phe Gly Phe Arg Lys Phe 
    130                 135                 140                 


Ser Ser Lys Val Gln Thr Leu Leu Glu Leu Leu Pro Glu His Asp Leu 
145                 150                 155                 160 


Pro Glu His Leu Lys Ala Lys Thr Cys Arg Arg Cys Val Val Ile Gly 
                165                 170                 175     


Ser Gly Gly Ile Leu His Gly Leu Glu Leu Gly His Thr Leu Asn Gln 
            180                 185                 190         


Phe Asp Val Val Ile Arg Leu Asn Ser Ala Pro Val Glu Gly Tyr Ser 
        195                 200                 205             


Glu His Val Gly Asn Lys Thr Thr Ile Arg Met Thr Tyr Pro Glu Gly 
    210                 215                 220                 


Ala Pro Leu Ser Asp Leu Glu Tyr Tyr Ser Asn Asp Leu Phe Val Ala 
225                 230                 235                 240 


Val Leu Phe Lys Ser Val Asp Phe Asn Trp Leu Gln Ala Met Val Lys 
                245                 250                 255     


Lys Glu Thr Leu Pro Phe Trp Val Arg Leu Phe Phe Trp Lys Gln Val 
            260                 265                 270         


Ala Glu Lys Ile Pro Leu Gln Pro Lys His Phe Arg Ile Leu Asn Pro 
        275                 280                 285             


Val Ile Ile Lys Glu Thr Ala Phe Asp Ile Leu Gln Tyr Ser Glu Pro 
    290                 295                 300                 


Gln Ser Arg Phe Trp Gly Arg Asp Lys Asn Val Pro Thr Ile Gly Val 
305                 310                 315                 320 


Ile Ala Val Val Leu Ala Thr His Leu Cys Asp Glu Val Ser Leu Ala 
                325                 330                 335     


Gly Phe Gly Tyr Asp Leu Asn Gln Pro Arg Thr Pro Leu His Tyr Phe 
            340                 345                 350         


Asp Ser Gln Cys Met Ala Ala Met Asn Phe Gln Thr Met His Asn Val 
        355                 360                 365             


Thr Thr Glu Thr Lys Phe Leu Leu Lys Leu Val Lys Glu Gly Val Val 
    370                 375                 380                 


Lys Asp Leu Ser Gly Gly Ile Asp Arg Glu Phe 
385                 390                 395 


<210>  888
<211>  596
<212>  PRT
<213>  Homo sapiens

<400>  888

Met Ala Ala Asn Ser Thr Ser Asp Leu His Thr Pro Gly Thr Gln Leu 
1               5                   10                  15      


Ser Val Ala Asp Ile Ile Val Ile Thr Val Tyr Phe Ala Leu Asn Val 
            20                  25                  30          


Ala Val Gly Ile Trp Ser Ser Cys Arg Ala Ser Arg Asn Thr Val Asn 
        35                  40                  45              


Gly Tyr Phe Leu Ala Gly Arg Asp Met Thr Trp Trp Pro Ile Gly Ala 
    50                  55                  60                  


Ser Leu Phe Ala Ser Ser Glu Gly Ser Gly Leu Phe Ile Gly Leu Ala 
65                  70                  75                  80  


Gly Ser Gly Ala Ala Gly Gly Leu Ala Val Ala Gly Phe Glu Trp Asn 
                85                  90                  95      


Ala Thr Tyr Val Leu Leu Ala Leu Ala Trp Val Phe Val Pro Ile Tyr 
            100                 105                 110         


Ile Ser Ser Glu Ile Val Thr Leu Pro Glu Tyr Ile Gln Lys Arg Tyr 
        115                 120                 125             


Gly Gly Gln Arg Ile Arg Met Tyr Leu Ser Val Leu Ser Leu Leu Leu 
    130                 135                 140                 


Ser Val Phe Thr Lys Ile Ser Leu Asp Leu Tyr Ala Gly Ala Leu Phe 
145                 150                 155                 160 


Val His Ile Cys Leu Gly Trp Asn Phe Tyr Leu Ser Thr Ile Leu Thr 
                165                 170                 175     


Leu Gly Ile Thr Ala Leu Tyr Thr Ile Ala Gly Gly Leu Ala Ala Val 
            180                 185                 190         


Ile Tyr Thr Asp Ala Leu Gln Thr Leu Ile Met Val Val Gly Ala Val 
        195                 200                 205             


Ile Leu Thr Ile Lys Ala Phe Asp Gln Ile Gly Gly Tyr Gly Gln Leu 
    210                 215                 220                 


Glu Ala Ala Tyr Ala Gln Ala Ile Pro Ser Arg Thr Ile Ala Asn Thr 
225                 230                 235                 240 


Thr Cys His Leu Pro Arg Thr Asp Ala Met His Met Phe Arg Asp Pro 
                245                 250                 255     


His Thr Gly Asp Leu Pro Trp Thr Gly Met Thr Phe Gly Leu Thr Ile 
            260                 265                 270         


Met Ala Thr Trp Tyr Trp Cys Thr Asp Gln Val Ile Val Gln Arg Ser 
        275                 280                 285             


Leu Ser Ala Arg Asp Leu Asn His Ala Lys Ala Gly Ser Ile Leu Ala 
    290                 295                 300                 


Ser Tyr Leu Lys Met Leu Pro Met Gly Leu Ile Ile Met Pro Gly Met 
305                 310                 315                 320 


Ile Ser Arg Ala Leu Phe Pro Asp Asp Val Gly Cys Val Val Pro Ser 
                325                 330                 335     


Glu Cys Leu Arg Ala Cys Gly Ala Glu Val Gly Cys Ser Asn Ile Ala 
            340                 345                 350         


Tyr Pro Lys Leu Val Met Glu Leu Met Pro Ile Gly Leu Arg Gly Leu 
        355                 360                 365             


Met Ile Ala Val Met Leu Ala Ala Leu Met Ser Ser Leu Thr Ser Ile 
    370                 375                 380                 


Phe Asn Ser Ser Ser Thr Leu Phe Thr Met Asp Ile Trp Arg Arg Leu 
385                 390                 395                 400 


Arg Pro Arg Ser Gly Glu Arg Glu Leu Leu Leu Val Gly Arg Leu Val 
                405                 410                 415     


Ile Val Ala Leu Ile Gly Val Ser Val Ala Trp Ile Pro Val Leu Gln 
            420                 425                 430         


Asp Ser Asn Ser Gly Gln Leu Phe Ile Tyr Met Gln Ser Val Thr Ser 
        435                 440                 445             


Ser Leu Ala Pro Pro Val Thr Ala Val Phe Val Leu Gly Val Phe Trp 
    450                 455                 460                 


Arg Arg Ala Asn Glu Gln Gly Ala Phe Trp Gly Leu Ile Ala Gly Leu 
465                 470                 475                 480 


Val Val Gly Ala Thr Arg Leu Val Leu Glu Phe Leu Asn Pro Ala Pro 
                485                 490                 495     


Pro Cys Gly Glu Pro Asp Thr Arg Pro Ala Val Leu Gly Ser Ile His 
            500                 505                 510         


Tyr Leu His Phe Ala Val Ala Leu Phe Ala Leu Ser Gly Ala Val Val 
        515                 520                 525             


Val Ala Gly Ser Leu Leu Thr Pro Pro Pro Gln Ser Val Gln Ile Glu 
    530                 535                 540                 


Asn Leu Thr Trp Trp Thr Leu Ala Gln Asp Val Pro Leu Gly Thr Lys 
545                 550                 555                 560 


Ala Gly Asp Gly Gln Thr Pro Gln Lys His Ala Phe Trp Ala Arg Val 
                565                 570                 575     


Cys Gly Phe Asn Ala Ile Leu Leu Met Cys Val Asn Ile Phe Phe Tyr 
            580                 585                 590         


Ala Tyr Phe Ala 
        595     


<210>  889
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  889

Met Leu Pro Asn Val Gly Ser Pro Pro Leu Pro Phe Arg Lys Cys Pro 
1               5                   10                  15      


Ser Gly Ala Gly Arg Thr Asn Arg Ala Ser Ala Val Ala Arg Thr Ser 
            20                  25                  30          


Ala Pro Glu Thr Arg Arg Gly Arg Ala Pro Ser Ser Gly Asp Ala Lys 
        35                  40                  45              


Met Ala Glu Gly Ala Arg Ala Arg Gly Pro Arg Gly Cys Arg Asp Arg 
    50                  55                  60                  


Asp Gly Pro Ala Gly Gly Ala Gly Lys Met Ala Ala Pro Arg Arg Gly 
65                  70                  75                  80  


Arg Gly Ser Ser Thr Val Leu Ser Ser Val Pro Leu Gln Met Leu Phe 
                85                  90                  95      


Tyr Leu Ser Gly Thr Tyr Tyr Ala Leu Tyr Phe Leu Ala Thr Leu Leu 
            100                 105                 110         


Met Ile Thr Tyr Lys Ser Gln Val Phe Ser Tyr Pro His Arg Tyr Leu 
        115                 120                 125             


Val Leu Asp Leu Ala Leu Leu Phe Leu Met Gly Ile Leu Glu Ala Val 
    130                 135                 140                 


Arg Leu Tyr Leu Gly Thr Arg Gly Asn Leu Thr Glu Ala Glu Arg Pro 
145                 150                 155                 160 


Leu Ala Ala Ser Leu Ala Leu Thr Ala Gly Thr Ala Leu Leu Ser Ala 
                165                 170                 175     


His Phe Leu Leu Trp Gln Ala Leu Val Leu Trp Ala Asp Trp Ala Leu 
            180                 185                 190         


Ser Ala Thr Leu Leu Ala Leu His Gly Leu Glu Ala Val Leu Gln Val 
        195                 200                 205             


Val Ala Ile Ala Ala Phe Thr Arg 
    210                 215     


<210>  890
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  890

Met Arg Ala His Ala Gln Arg Gly Arg Gly Cys Thr Arg Arg Ser Ala 
1               5                   10                  15      


Ala Val Leu Met Ala Arg His Gly Leu Pro Leu Leu Pro Leu Leu Ser 
            20                  25                  30          


Leu Leu Val Gly Ala Trp Leu Lys Leu Gly Asn Gly Gln Ala Thr Ser 
        35                  40                  45              


Met Val Gln Leu Gln Gly Gly Arg Phe Leu Met Gly Thr Asn Ser Pro 
    50                  55                  60                  


Asp Ser Arg Asp Gly Glu Gly Pro Val Arg Glu Ala Thr Val Lys Pro 
65                  70                  75                  80  


Phe Ala Ile Asp Ile Phe Pro Val Thr Asn Lys Asp Phe Arg Asp Phe 
                85                  90                  95      


Val Arg Glu Lys Lys Tyr Arg Thr Glu Ala Glu Met Phe Gly Trp Ser 
            100                 105                 110         


Phe Val Phe Glu Asp Phe Val Ser Asp Glu Leu Arg Asn Lys Ala Thr 
        115                 120                 125             


Gln Pro Met Lys Pro Ala Gly Pro Gly Ser Gly Ile Arg Glu Arg Leu 
    130                 135                 140                 


Glu His Pro Val Leu His Val Ser Trp Asn Asp Ala Arg Ala Tyr Cys 
145                 150                 155                 160 


Ala Trp Arg Gly Lys Arg Leu Pro Thr Glu Glu Glu Trp Glu Phe Ala 
                165                 170                 175     


Ala Arg Gly Gly Leu Lys Gly Gln Val Tyr Pro Trp Gly Asn Trp Phe 
            180                 185                 190         


Gln Pro Asn Arg Thr Asn Leu Trp Gln Gly Lys Phe Pro Lys Gly Asp 
        195                 200                 205             


Lys Ala Glu Asp Gly Phe His Gly Val Ser Pro Val Asn Ala Phe Pro 
    210                 215                 220                 


Ala Gln Asn Asn Tyr Gly Leu Tyr Asp Leu Leu Gly Asn Val Trp Glu 
225                 230                 235                 240 


Trp Thr Ala Ser Pro Tyr Gln Ala Ala Glu Gln Asp Met Arg Val Leu 
                245                 250                 255     


Arg Gly Ala Ser Trp Ile Asp Thr Ala Asp Gly Ser Ala Asn His Arg 
            260                 265                 270         


Ala Arg Val Thr Thr Arg Met Gly Asn Thr Pro Asp Ser Ala Ser Asp 
        275                 280                 285             


Asn Leu Gly Phe Arg Cys Ala Ala Asp Ala Gly Arg Pro Pro Gly Glu 
    290                 295                 300                 


Leu 
305 


<210>  891
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  891

Met Arg Ala His Ala Gln Arg Gly Arg Gly Cys Thr Arg Arg Ser Ala 
1               5                   10                  15      


Ala Val Leu Met Ala Arg His Gly Leu Pro Leu Leu Pro Leu Leu Ser 
            20                  25                  30          


Leu Leu Val Gly Ala Trp Leu Lys Leu Gly Asn Gly Gln Ala Thr Ser 
        35                  40                  45              


Met Val Gln Leu Gln Gly Gly Arg Phe Leu Met Gly Thr Asn Ser Pro 
    50                  55                  60                  


Asp Ser Arg Asp Gly Glu Gly Pro Val Arg Glu Ala Thr Val Lys Pro 
65                  70                  75                  80  


Phe Ala Ile Asp Ile Phe Pro Val Thr Asn Lys Asp Phe Arg Asp Phe 
                85                  90                  95      


Val Arg Glu Lys Lys Tyr Arg Thr Glu Ala Glu Met Phe Gly Trp Ser 
            100                 105                 110         


Phe Val Phe Glu Asp Phe Val Ser Asp Glu Leu Arg Asn Lys Ala Thr 
        115                 120                 125             


Gln Pro Met Lys Gly Lys Phe Pro Lys Gly Asp Lys Ala Glu Asp Gly 
    130                 135                 140                 


Phe His Gly Val Ser Pro Val Asn Ala Phe Pro Ala Gln Asn Asn Tyr 
145                 150                 155                 160 


Gly Leu Tyr Asp Leu Leu Gly Asn Val Trp Glu Trp Thr Ala Ser Pro 
                165                 170                 175     


Tyr Gln Ala Ala Glu Gln Asp Met Arg Val Leu Arg Gly Ala Ser Trp 
            180                 185                 190         


Ile Asp Thr Ala Asp Gly Ser Ala Asn His Arg Ala Arg Val Thr Thr 
        195                 200                 205             


Arg Met Gly Asn Thr Pro Asp Ser Ala Ser Asp Asn Leu Gly Phe Arg 
    210                 215                 220                 


Cys Ala Ala Asp Ala Gly Arg Pro Pro Gly Glu Leu 
225                 230                 235     


<210>  892
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  892

Met Arg Lys Arg Thr Glu Pro Val Ala Leu Glu His Glu Arg Cys Ala 
1               5                   10                  15      


Ala Ala Gly Ser Ser Ser Ser Gly Ser Ala Ala Ala Ala Leu Asp Ala 
            20                  25                  30          


Asp Cys Arg Leu Lys Gln Asn Leu Arg Leu Thr Gly Pro Ala Ala Ala 
        35                  40                  45              


Glu Pro Arg Cys Ala Ala Asp Ala Gly Met Lys Arg Ala Leu Gly Arg 
    50                  55                  60                  


Arg Lys Gly Val Trp Leu Arg Leu Arg Lys Ile Leu Phe Cys Val Leu 
65                  70                  75                  80  


Gly Leu Tyr Ile Ala Ile Pro Phe Leu Ile Lys Leu Cys Pro Gly Ile 
                85                  90                  95      


Gln Ala Lys Leu Ile Phe Leu Asn Phe Val Arg Val Pro Tyr Phe Ile 
            100                 105                 110         


Asp Leu Lys Lys Pro Gln Asp Gln Gly Leu Asn His Thr Cys Asn Tyr 
        115                 120                 125             


Tyr Leu Gln Pro Glu Glu Asp Val Thr Ile Gly Val Trp His Thr Val 
    130                 135                 140                 


Pro Ala Val Trp Trp Lys Asn Ala Gln Gly Lys Asp Gln Met Trp Tyr 
145                 150                 155                 160 


Glu Asp Ala Leu Ala Ser Ser His Pro Ile Ile Leu Tyr Leu His Gly 
                165                 170                 175     


Asn Ala Gly Thr Arg Gly Gly Asp His Arg Val Glu Leu Tyr Lys Val 
            180                 185                 190         


Leu Ser Ser Leu Gly Tyr His Val Val Thr Phe Asp Tyr Arg Gly Trp 
        195                 200                 205             


Gly Asp Ser Val Gly Thr Pro Ser Glu Arg Gly Met Thr Tyr Asp Ala 
    210                 215                 220                 


Leu His Val Phe Asp Trp Ile Lys Ala Arg Ser Gly Asp Asn Pro Val 
225                 230                 235                 240 


Tyr Ile Trp Gly His Ser Leu Gly Thr Gly Val Ala Thr Asn Leu Val 
                245                 250                 255     


Arg Arg Leu Cys Glu Arg Glu Thr Pro Pro Asp Ala Leu Ile Leu Glu 
            260                 265                 270         


Ser Pro Phe Thr Asn Ile Arg Glu Glu Ala Lys Ser His Pro Phe Ser 
        275                 280                 285             


Val Ile Tyr Arg Tyr Phe Pro Gly Phe Asp Trp Phe Phe Leu Asp Pro 
    290                 295                 300                 


Ile Thr Ser Ser Gly Ile Lys Phe Ala Asn Asp Glu Asn Val Lys His 
305                 310                 315                 320 


Ile Ser Cys Pro Leu Leu Ile Leu His Ala Glu Asp Asp Pro Val Val 
                325                 330                 335     


Pro Phe Gln Leu Gly Arg Lys Leu Tyr Ser Ile Ala Ala Pro Ala Arg 
            340                 345                 350         


Ser Phe Arg Asp Phe Lys Val Gln Phe Val Pro Phe His Ser Asp Leu 
        355                 360                 365             


Gly Tyr Arg His Lys Tyr Ile Tyr Lys Ser Pro Glu Leu Pro Arg Ile 
    370                 375                 380                 


Leu Arg Glu Phe Leu Gly Lys Ser Glu Pro Glu His Gln His 
385                 390                 395             


<210>  893
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  893

Met Ala Asp Thr Arg Ser Val His Glu Thr Arg Phe Glu Ala Ala Val 
1               5                   10                  15      


Lys Val Ile Gln Ser Leu Pro Lys Asn Gly Ser Phe Gln Pro Thr Asn 
            20                  25                  30          


Glu Met Met Leu Lys Phe Tyr Ser Phe Tyr Lys Gln Ala Thr Glu Gly 
        35                  40                  45              


Pro Cys Lys Leu Ser Arg Pro Gly Phe Trp Asp Pro Ile Gly Arg Tyr 
    50                  55                  60                  


Lys Trp Asp Ala Trp Ser Ser Leu Gly Asp Met Thr Lys Glu Glu Ala 
65                  70                  75                  80  


Met Ile Ala Tyr Val Glu Glu Met Lys Lys Ile Ile Glu Thr Met Pro 
                85                  90                  95      


Met Thr Glu Lys Val Glu Glu Leu Leu Arg Val Ile Gly Pro Phe Tyr 
            100                 105                 110         


Glu Ile Val Glu Asp Lys Lys Ser Gly Arg Ser Ser Asp Ile Thr Ser 
        115                 120                 125             


Asp Leu Gly Asn Val Leu Thr Ser Thr Pro Asn Ala Lys Thr Val Asn 
    130                 135                 140                 


Gly Lys Ala Glu Ser Ser Asp Ser Gly Ala Glu Ser Glu Glu Glu Glu 
145                 150                 155                 160 


Ala Gln Glu Glu Val Lys Gly Ala Glu Gln Ser Asp Asn Asp Lys Lys 
                165                 170                 175     


Met Met Lys Lys Ser Ala Asp His Lys Asn Leu Glu Val Ile Val Thr 
            180                 185                 190         


Asn Gly Tyr Asp Lys Asp Gly Phe Val Gln Asp Ile Gln Asn Asp Ile 
        195                 200                 205             


His Ala Ser Ser Ser Leu Asn Gly Arg Ser Thr Glu Glu Val Lys Pro 
    210                 215                 220                 


Ile Asp Glu Asn Leu Gly Gln Thr Gly Lys Ser Ala Val Cys Ile His 
225                 230                 235                 240 


Gln Asp Ile Asn Asp Asp His Val Glu Asp Val Thr Gly Ile Gln His 
                245                 250                 255     


Leu Thr Ser Asp Ser Asp Ser Glu Val Tyr Cys Asp Ser Met Glu Gln 
            260                 265                 270         


Phe Gly Gln Glu Glu Ser Leu Asp Ser Phe Thr Ser Asn Asn Gly Pro 
        275                 280                 285             


Phe Gln Tyr Tyr Leu Gly Gly His Ser Ser Gln Pro Met Glu Asn Ser 
    290                 295                 300                 


Gly Phe Arg Glu Asp Ile Gln Val Pro Pro Gly Asn Gly Asn Ile Gly 
305                 310                 315                 320 


Asn Met Gln Val Val Ala Val Glu Gly Lys Gly Glu Val Lys His Gly 
                325                 330                 335     


Gly Glu Asp Gly Arg Asn Asn Ser Gly Ala Pro His Arg Glu Lys Arg 
            340                 345                 350         


Gly Gly Glu Thr Asp Glu Phe Ser Asn Val Arg Arg Gly Arg Gly His 
        355                 360                 365             


Arg Met Gln His Leu Ser Glu Gly Thr Lys Gly Arg Gln Val Gly Ser 
    370                 375                 380                 


Gly Gly Asp Gly Glu Arg Trp Gly Ser Asp Arg Gly Ser Arg Gly Ser 
385                 390                 395                 400 


Leu Asn Glu Gln Ile Ala Leu Val Leu Met Arg Leu Gln Glu Asp Met 
                405                 410                 415     


Gln Asn Val Leu Gln Arg Leu Gln Lys Leu Glu Thr Leu Thr Ala Leu 
            420                 425                 430         


Gln Ala Lys Ser Ser Thr Ser Thr Leu Gln Thr Ala Pro Gln Pro Thr 
        435                 440                 445             


Ser Gln Arg Pro Ser Trp Trp Pro Phe Glu Met Ser Pro Gly Val Leu 
    450                 455                 460                 


Thr Phe Ala Ile Ile Trp Pro Phe Ile Ala Gln Trp Leu Val Tyr Leu 
465                 470                 475                 480 


Tyr Tyr Gln Arg Arg Arg Arg Lys Leu Asn 
                485                 490 


<210>  894
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  894

Met Trp Ile Gln Gln Leu Leu Gly Leu Ser Ser Met Ser Ile Arg Trp 
1               5                   10                  15      


Pro Gly Arg Pro Leu Gly Ser His Ala Trp Ile Leu Ile Ala Met Phe 
            20                  25                  30          


Gln Leu Ala Val Asp Leu Pro Ala Cys Glu Ala Leu Gly Pro Gly Pro 
        35                  40                  45              


Glu Phe Trp Leu Leu Pro Arg Ser Pro Pro Arg Pro Pro Arg Leu Trp 
    50                  55                  60                  


Ser Phe Arg Ser Gly Gln Pro Ala Arg Val Pro Ala Pro Val Trp Ser 
65                  70                  75                  80  


Pro Arg Pro Pro Arg Val Glu Arg Ile His Gly Gln Met Gln Met Pro 
                85                  90                  95      


Arg Ala Arg Arg Ala His Arg Pro Arg Asp Gln Ala Ala Ala Leu Val 
            100                 105                 110         


Pro Lys Ala Gly Leu Ala Lys Pro Pro Ala Ala Ala Lys Ser Ser Pro 
        115                 120                 125             


Ser Leu Ala Ser Ser Ser Ser Ser Ser Ser Ser Ala Val Ala Gly Gly 
    130                 135                 140                 


Ala Pro Glu Gln Gln Ala Leu Leu Arg Arg Gly Lys Arg His Leu Gln 
145                 150                 155                 160 


Gly Asp Gly Leu Ser Ser Phe Asp Ser Arg Gly Ser Arg Pro Thr Thr 
                165                 170                 175     


Glu Thr Glu Phe Ile Ala Trp Gly Pro Thr Gly Asp Glu Glu Ala Leu 
            180                 185                 190         


Glu Ser Asn Thr Phe Pro Gly Val Tyr Gly Pro Thr Thr Val Ser Ile 
        195                 200                 205             


Leu Gln Thr Arg Lys Thr Thr Val Ala Ala Thr Thr Thr Thr Thr Thr 
    210                 215                 220                 


Thr Ala Thr Pro Met Thr Leu Gln Thr Lys Gly Phe Thr Glu Ser Leu 
225                 230                 235                 240 


Asp Pro Arg Arg Arg Ile Pro Gly Gly Val Ser Thr Thr Glu Pro Ser 
                245                 250                 255     


Thr Ser Pro Ser Asn Asn Gly Glu Val Thr Gln Pro Pro Arg Ile Leu 
            260                 265                 270         


Gly Glu Ala Ser Gly Leu Ala Val His Gln Ile Ile Thr Ile Thr Val 
        275                 280                 285             


Ser Leu Ile Met Val Ile Ala Ala Leu Ile Thr Thr Leu Val Leu Lys 
    290                 295                 300                 


Asn Cys Cys Ala Gln Ser Gly Asn Thr Arg Arg Asn Ser His Gln Arg 
305                 310                 315                 320 


Lys Thr Asn Gln Gln Glu Glu Ser Cys Gln Asn Leu Thr Asp Phe Pro 
                325                 330                 335     


Ser Ala Arg Val Pro Ser Ser Leu Asp Ile Phe Thr Ala Tyr Asn Glu 
            340                 345                 350         


Thr Leu Gln Cys Ser His Glu Cys Val Arg Ala Ser Val Pro Val Tyr 
        355                 360                 365             


Thr Asp Glu Thr Leu His Ser Thr Thr Gly Glu Tyr Lys Ser Thr Phe 
    370                 375                 380                 


Asn Gly Asn Arg Pro Ser Ser Ser Asp Arg His Leu Ile Pro Val Ala 
385                 390                 395                 400 


Phe Val Ser Glu Lys Trp Phe Glu Ile Ser Cys 
                405                 410     


<210>  895
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  895

Met Ser Ser Ala Pro Glu Pro Pro Thr Phe Lys Lys Glu Pro Pro Lys 
1               5                   10                  15      


Glu Lys Glu Phe Gln Ser Pro Gly Leu Arg Gly Val Arg Thr Thr Thr 
            20                  25                  30          


Leu Phe Arg Ala Val Asn Pro Glu Leu Phe Ile Lys Pro Asn Lys Pro 
        35                  40                  45              


Val Met Ala Phe Gly Leu Val Thr Leu Ser Leu Cys Val Ala Tyr Ile 
    50                  55                  60                  


Gly Tyr Leu His Ala Ile Gln Glu Asn Lys Lys Asp Leu Tyr Glu Ala 
65                  70                  75                  80  


Ile Asp Ser Glu Gly His Ser Tyr Met Arg Arg Lys Thr Ser Lys Trp 
                85                  90                  95      


Asp 
    


<210>  896
<211>  1091
<212>  PRT
<213>  Homo sapiens

<400>  896

Met Ser Glu Met Ser Gly Ala Thr Thr Ser Leu Ala Thr Val Ala Leu 
1               5                   10                  15      


Asp Pro Pro Ser Asp Arg Thr Ser His Pro Gln Asp Val Ile Glu Asp 
            20                  25                  30          


Leu Ser Gln Asn Ser Ile Thr Gly Glu His Ser Gln Leu Leu Asp Asp 
        35                  40                  45              


Gly His Lys Lys Ala Arg Asn Ala Tyr Leu Asn Asn Ser Asn Tyr Glu 
    50                  55                  60                  


Glu Gly Asp Glu Tyr Phe Asp Lys Asn Leu Ala Leu Phe Glu Glu Glu 
65                  70                  75                  80  


Met Asp Thr Arg Pro Lys Val Ser Ser Leu Leu Asn Arg Met Ala Asn 
                85                  90                  95      


Tyr Thr Asn Leu Thr Gln Gly Ala Lys Glu His Glu Glu Ala Glu Asn 
            100                 105                 110         


Ile Thr Glu Gly Lys Lys Lys Pro Thr Lys Thr Pro Gln Met Gly Thr 
        115                 120                 125             


Phe Met Gly Val Tyr Leu Pro Cys Leu Gln Asn Ile Phe Gly Val Ile 
    130                 135                 140                 


Leu Phe Leu Arg Leu Thr Trp Val Val Gly Thr Ala Gly Val Leu Gln 
145                 150                 155                 160 


Ala Phe Ala Ile Val Leu Ile Cys Cys Cys Cys Thr Met Leu Thr Ala 
                165                 170                 175     


Ile Ser Met Ser Ala Ile Ala Thr Asn Gly Val Val Pro Ala Gly Gly 
            180                 185                 190         


Ser Tyr Phe Met Ile Ser Arg Ala Leu Gly Pro Glu Phe Gly Gly Ala 
        195                 200                 205             


Val Gly Leu Cys Phe Tyr Leu Gly Thr Thr Phe Ala Ala Ala Met Tyr 
    210                 215                 220                 


Ile Leu Gly Ala Ile Glu Ile Phe Leu Val Tyr Ile Val Pro Arg Ala 
225                 230                 235                 240 


Ala Ile Phe His Ser Asp Asp Ala Leu Lys Glu Ser Ala Ala Met Leu 
                245                 250                 255     


Asn Asn Met Arg Val Tyr Gly Thr Ala Phe Leu Val Leu Met Val Leu 
            260                 265                 270         


Val Val Phe Ile Gly Val Arg Tyr Val Asn Lys Phe Ala Ser Leu Phe 
        275                 280                 285             


Leu Ala Cys Val Ile Val Ser Ile Leu Ala Ile Tyr Ala Gly Ala Ile 
    290                 295                 300                 


Lys Ser Ser Phe Ala Pro Pro His Phe Pro Val Cys Met Leu Gly Asn 
305                 310                 315                 320 


Arg Thr Leu Ser Ser Arg His Ile Asp Val Cys Ser Lys Thr Lys Glu 
                325                 330                 335     


Ile Asn Asn Met Thr Val Pro Ser Lys Leu Trp Gly Phe Phe Cys Asn 
            340                 345                 350         


Ser Ser Gln Phe Phe Asn Ala Thr Cys Asp Glu Tyr Phe Val His Asn 
        355                 360                 365             


Asn Val Thr Ser Ile Gln Gly Ile Pro Gly Leu Ala Ser Gly Ile Ile 
    370                 375                 380                 


Thr Glu Asn Leu Trp Ser Asn Tyr Leu Pro Lys Gly Glu Ile Ile Glu 
385                 390                 395                 400 


Lys Pro Ser Ala Lys Ser Ser Asp Val Leu Gly Ser Leu Asn His Glu 
                405                 410                 415     


Tyr Val Leu Val Asp Ile Thr Thr Ser Phe Thr Leu Leu Val Gly Ile 
            420                 425                 430         


Phe Phe Pro Ser Val Thr Gly Ile Met Ala Gly Ser Asn Arg Ser Gly 
        435                 440                 445             


Asp Leu Lys Asp Ala Gln Lys Ser Ile Pro Ile Gly Thr Ile Leu Ala 
    450                 455                 460                 


Ile Leu Thr Thr Ser Phe Val Tyr Leu Ser Asn Val Val Leu Phe Gly 
465                 470                 475                 480 


Ala Cys Ile Glu Gly Val Val Leu Arg Asp Lys Phe Gly Asp Ala Val 
                485                 490                 495     


Lys Gly Asn Leu Val Val Gly Thr Leu Ser Trp Pro Ser Pro Trp Val 
            500                 505                 510         


Ile Val Ile Gly Ser Phe Phe Ser Thr Cys Gly Ala Gly Leu Gln Ser 
        515                 520                 525             


Leu Thr Gly Ala Pro Arg Leu Leu Gln Ala Ile Ala Lys Asp Asn Ile 
    530                 535                 540                 


Ile Pro Phe Leu Arg Val Phe Gly His Ser Lys Ala Asn Gly Glu Pro 
545                 550                 555                 560 


Thr Trp Ala Leu Leu Leu Thr Ala Ala Ile Ala Glu Leu Gly Ile Leu 
                565                 570                 575     


Ile Ala Ser Leu Asp Leu Val Ala Pro Ile Leu Ser Met Phe Phe Leu 
            580                 585                 590         


Met Cys Tyr Leu Phe Val Asn Leu Ala Cys Ala Leu Gln Thr Leu Leu 
        595                 600                 605             


Arg Thr Pro Asn Trp Arg Pro Arg Phe Arg Tyr Tyr His Trp Ala Leu 
    610                 615                 620                 


Ser Phe Met Gly Met Ser Ile Cys Leu Ala Leu Met Phe Ile Ser Ser 
625                 630                 635                 640 


Trp Tyr Tyr Ala Ile Val Ala Met Val Ile Ala Gly Met Ile Tyr Lys 
                645                 650                 655     


Tyr Ile Glu Tyr Gln Gly Ala Glu Lys Glu Trp Gly Asp Gly Ile Arg 
            660                 665                 670         


Gly Leu Ser Leu Ser Ala Ala Arg Phe Ala Leu Leu Arg Leu Glu Glu 
        675                 680                 685             


Gly Pro Pro His Thr Lys Asn Trp Arg Pro Gln Leu Leu Val Leu Leu 
    690                 695                 700                 


Lys Leu Asp Glu Asp Leu His Val Lys His Pro Arg Leu Leu Thr Phe 
705                 710                 715                 720 


Ala Ser Gln Leu Lys Ala Gly Lys Gly Leu Thr Ile Val Gly Ser Val 
                725                 730                 735     


Ile Val Gly Asn Phe Leu Glu Asn Tyr Gly Glu Ala Leu Ala Ala Glu 
            740                 745                 750         


Gln Thr Ile Lys His Leu Met Glu Ala Glu Lys Val Lys Gly Phe Cys 
        755                 760                 765             


Gln Leu Val Val Ala Ala Lys Leu Arg Glu Gly Ile Ser His Leu Ile 
    770                 775                 780                 


Gln Ser Cys Gly Leu Gly Gly Met Lys His Asn Thr Val Val Met Gly 
785                 790                 795                 800 


Trp Pro Asn Gly Trp Arg Gln Ser Glu Asp Ala Arg Ala Trp Lys Thr 
                805                 810                 815     


Phe Ile Gly Thr Val Arg Val Thr Thr Ala Ala His Leu Ala Leu Leu 
            820                 825                 830         


Val Ala Lys Asn Ile Ser Phe Phe Pro Ser Asn Val Glu Gln Phe Ser 
        835                 840                 845             


Glu Gly Asn Ile Asp Val Trp Trp Ile Val His Asp Gly Gly Met Leu 
    850                 855                 860                 


Met Leu Leu Pro Phe Leu Leu Lys Gln His Lys Val Trp Arg Lys Cys 
865                 870                 875                 880 


Ser Ile Arg Ile Phe Thr Val Ala Gln Leu Glu Asp Asn Ser Ile Gln 
                885                 890                 895     


Met Lys Lys Asp Leu Ala Thr Phe Leu Tyr His Leu Arg Ile Glu Ala 
            900                 905                 910         


Glu Val Glu Val Val Glu Met His Asp Ser Asp Ile Ser Ala Tyr Thr 
        915                 920                 925             


Tyr Glu Arg Thr Leu Met Met Glu Gln Arg Ser Gln Met Leu Arg His 
    930                 935                 940                 


Met Arg Leu Ser Lys Thr Glu Arg Asp Arg Glu Ala Gln Leu Val Lys 
945                 950                 955                 960 


Asp Arg Asn Ser Met Leu Arg Leu Thr Ser Ile Gly Ser Asp Glu Asp 
                965                 970                 975     


Glu Glu Thr Glu Thr Tyr Gln Glu Lys Val His Met Thr Trp Thr Lys 
            980                 985                 990         


Asp Lys Tyr Met Ala Ser Arg Gly  Gln Lys Ala Lys Ser  Met Glu Gly 
        995                 1000                 1005             


Phe Gln  Asp Leu Leu Asn Met  Arg Pro Asp Gln Ser  Asn Val Arg 
    1010                 1015                 1020             


Arg Met  His Thr Ala Val Lys  Leu Asn Glu Val Ile  Val Asn Lys 
    1025                 1030                 1035             


Ser His  Glu Ala Lys Leu Val  Leu Leu Asn Met Pro  Gly Pro Pro 
    1040                 1045                 1050             


Arg Asn  Pro Glu Gly Asp Glu  Asn Tyr Met Glu Phe  Leu Glu Val 
    1055                 1060                 1065             


Leu Thr  Glu Gly Leu Glu Arg  Val Leu Leu Val Arg  Gly Gly Gly 
    1070                 1075                 1080             


Ser Glu  Val Ile Thr Ile Tyr  Ser 
    1085                 1090     


<210>  897
<211>  1091
<212>  PRT
<213>  Homo sapiens

<400>  897

Met Ser Glu Met Ser Gly Ala Thr Thr Ser Leu Ala Thr Val Ala Leu 
1               5                   10                  15      


Asp Pro Pro Ser Asp Arg Thr Ser His Pro Gln Asp Val Ile Glu Asp 
            20                  25                  30          


Leu Ser Gln Asn Ser Ile Thr Gly Glu His Ser Gln Leu Leu Asp Asp 
        35                  40                  45              


Gly His Lys Lys Ala Arg Asn Ala Tyr Leu Asn Asn Ser Asn Tyr Glu 
    50                  55                  60                  


Glu Gly Asp Glu Tyr Phe Asp Lys Asn Leu Ala Leu Phe Glu Glu Glu 
65                  70                  75                  80  


Met Asp Thr Arg Pro Lys Val Ser Ser Leu Leu Asn Arg Met Ala Asn 
                85                  90                  95      


Tyr Thr Asn Leu Thr Gln Gly Ala Lys Glu His Glu Glu Ala Glu Asn 
            100                 105                 110         


Ile Thr Glu Gly Lys Lys Lys Pro Thr Lys Thr Pro Gln Met Gly Thr 
        115                 120                 125             


Phe Met Gly Val Tyr Leu Pro Cys Leu Gln Asn Ile Phe Gly Val Ile 
    130                 135                 140                 


Leu Phe Leu Arg Leu Thr Trp Val Val Gly Thr Ala Gly Val Leu Gln 
145                 150                 155                 160 


Ala Phe Ala Ile Val Leu Ile Cys Cys Cys Cys Thr Met Leu Thr Ala 
                165                 170                 175     


Ile Ser Met Ser Ala Ile Ala Thr Asn Gly Val Val Pro Ala Gly Gly 
            180                 185                 190         


Ser Tyr Phe Met Ile Ser Arg Ala Leu Gly Pro Glu Phe Gly Gly Ala 
        195                 200                 205             


Val Gly Leu Cys Phe Tyr Leu Gly Thr Thr Phe Ala Ala Ala Met Tyr 
    210                 215                 220                 


Ile Leu Gly Ala Ile Glu Ile Phe Leu Val Tyr Ile Val Pro Arg Ala 
225                 230                 235                 240 


Ala Ile Phe His Ser Asp Asp Ala Leu Lys Glu Ser Ala Ala Met Leu 
                245                 250                 255     


Asn Asn Met Arg Val Tyr Gly Thr Ala Phe Leu Val Leu Met Val Leu 
            260                 265                 270         


Val Val Phe Ile Gly Val Arg Tyr Val Asn Lys Phe Ala Ser Leu Phe 
        275                 280                 285             


Leu Ala Cys Val Ile Val Ser Ile Leu Ala Ile Tyr Ala Gly Ala Ile 
    290                 295                 300                 


Lys Ser Ser Phe Ala Pro Pro His Phe Pro Val Cys Met Leu Gly Asn 
305                 310                 315                 320 


Arg Thr Leu Ser Ser Arg His Ile Asp Val Cys Ser Lys Thr Lys Glu 
                325                 330                 335     


Ile Asn Asn Met Thr Val Pro Ser Lys Leu Trp Gly Phe Phe Cys Asn 
            340                 345                 350         


Ser Ser Gln Phe Phe Asn Ala Thr Cys Asp Glu Tyr Phe Val His Asn 
        355                 360                 365             


Asn Val Thr Ser Ile Gln Gly Ile Pro Gly Leu Ala Ser Gly Ile Ile 
    370                 375                 380                 


Thr Glu Asn Leu Trp Ser Asn Tyr Leu Pro Lys Gly Glu Ile Ile Glu 
385                 390                 395                 400 


Lys Pro Ser Ala Lys Ser Ser Asp Val Leu Gly Ser Leu Asn His Glu 
                405                 410                 415     


Tyr Val Leu Val Asp Ile Thr Thr Ser Phe Thr Leu Leu Val Gly Ile 
            420                 425                 430         


Phe Phe Pro Ser Val Thr Gly Ile Met Ala Gly Ser Asn Arg Ser Gly 
        435                 440                 445             


Asp Leu Lys Asp Ala Gln Lys Ser Ile Pro Ile Gly Thr Ile Leu Ala 
    450                 455                 460                 


Ile Leu Thr Thr Ser Phe Val Tyr Leu Ser Asn Val Val Leu Phe Gly 
465                 470                 475                 480 


Ala Cys Ile Glu Gly Val Val Leu Arg Asp Lys Phe Gly Asp Ala Val 
                485                 490                 495     


Lys Gly Asn Leu Val Val Gly Thr Leu Ser Trp Pro Ser Pro Trp Val 
            500                 505                 510         


Ile Val Ile Gly Ser Phe Phe Ser Thr Cys Gly Ala Gly Leu Gln Ser 
        515                 520                 525             


Leu Thr Gly Ala Pro Arg Leu Leu Gln Ala Ile Ala Lys Asp Asn Ile 
    530                 535                 540                 


Ile Pro Phe Leu Arg Val Phe Gly His Ser Lys Ala Asn Gly Glu Pro 
545                 550                 555                 560 


Thr Trp Ala Leu Leu Leu Thr Ala Ala Ile Ala Glu Leu Gly Ile Leu 
                565                 570                 575     


Ile Ala Ser Leu Asp Leu Val Ala Pro Ile Leu Ser Met Phe Phe Leu 
            580                 585                 590         


Met Cys Tyr Leu Phe Val Asn Leu Ala Cys Ala Leu Gln Thr Leu Leu 
        595                 600                 605             


Arg Thr Pro Asn Trp Arg Pro Arg Phe Arg Tyr Tyr His Trp Ala Leu 
    610                 615                 620                 


Ser Phe Met Gly Met Ser Ile Cys Leu Ala Leu Met Phe Ile Ser Ser 
625                 630                 635                 640 


Trp Tyr Tyr Ala Ile Val Ala Met Val Ile Ala Gly Met Ile Tyr Lys 
                645                 650                 655     


Tyr Ile Glu Tyr Gln Gly Ala Glu Lys Glu Trp Gly Asp Gly Ile Arg 
            660                 665                 670         


Gly Leu Ser Leu Ser Ala Ala Arg Phe Ala Leu Leu Arg Leu Glu Glu 
        675                 680                 685             


Gly Pro Pro His Thr Lys Asn Trp Arg Pro Gln Leu Leu Val Leu Leu 
    690                 695                 700                 


Lys Leu Asp Glu Asp Leu His Val Lys His Pro Arg Leu Leu Thr Phe 
705                 710                 715                 720 


Ala Ser Gln Leu Lys Ala Gly Lys Gly Leu Thr Ile Val Gly Ser Val 
                725                 730                 735     


Ile Val Gly Asn Phe Leu Glu Asn Tyr Gly Glu Ala Leu Ala Ala Glu 
            740                 745                 750         


Gln Thr Ile Lys His Leu Met Glu Ala Glu Lys Val Lys Gly Phe Cys 
        755                 760                 765             


Gln Leu Val Val Ala Ala Lys Leu Arg Glu Gly Ile Ser His Leu Ile 
    770                 775                 780                 


Gln Ser Cys Gly Leu Gly Gly Met Lys His Asn Thr Val Val Met Gly 
785                 790                 795                 800 


Trp Pro Asn Gly Trp Arg Gln Ser Glu Asp Ala Arg Ala Trp Lys Thr 
                805                 810                 815     


Phe Ile Gly Thr Val Arg Val Thr Thr Ala Ala His Leu Ala Leu Leu 
            820                 825                 830         


Val Ala Lys Asn Ile Ser Phe Phe Pro Ser Asn Val Glu Gln Phe Ser 
        835                 840                 845             


Glu Gly Asn Ile Asp Val Trp Trp Ile Val His Asp Gly Gly Met Leu 
    850                 855                 860                 


Met Leu Leu Pro Phe Leu Leu Lys Gln His Lys Val Trp Arg Lys Cys 
865                 870                 875                 880 


Ser Ile Arg Ile Phe Thr Val Ala Gln Leu Glu Asp Asn Ser Ile Gln 
                885                 890                 895     


Met Lys Lys Asp Leu Ala Thr Phe Leu Tyr His Leu Arg Ile Glu Ala 
            900                 905                 910         


Glu Val Glu Val Val Glu Met His Asp Ser Asp Ile Ser Ala Tyr Thr 
        915                 920                 925             


Tyr Glu Arg Thr Leu Met Met Glu Gln Arg Ser Gln Met Leu Arg His 
    930                 935                 940                 


Met Arg Leu Ser Lys Thr Glu Arg Asp Arg Glu Ala Gln Leu Val Lys 
945                 950                 955                 960 


Asp Arg Asn Ser Met Leu Arg Leu Thr Ser Ile Gly Ser Asp Glu Asp 
                965                 970                 975     


Glu Glu Thr Glu Thr Tyr Gln Glu Lys Val His Met Thr Trp Thr Lys 
            980                 985                 990         


Asp Lys Tyr Met Ala Ser Arg Gly  Gln Lys Ala Lys Ser  Met Glu Gly 
        995                 1000                 1005             


Phe Gln  Asp Leu Leu Asn Met  Arg Pro Asp Gln Ser  Asn Val Arg 
    1010                 1015                 1020             


Arg Met  His Thr Ala Val Lys  Leu Asn Glu Val Ile  Val Asn Lys 
    1025                 1030                 1035             


Ser His  Glu Ala Lys Leu Val  Leu Leu Asn Met Pro  Gly Pro Pro 
    1040                 1045                 1050             


Arg Asn  Pro Glu Gly Asp Glu  Asn Tyr Met Glu Phe  Leu Glu Val 
    1055                 1060                 1065             


Leu Thr  Glu Gly Leu Glu Arg  Val Leu Leu Val Arg  Gly Gly Gly 
    1070                 1075                 1080             


Ser Glu  Val Ile Thr Ile Tyr  Ser 
    1085                 1090     


<210>  898
<211>  1141
<212>  PRT
<213>  Homo sapiens

<400>  898

Met Ala Ser Val Arg Phe Met Val Thr Pro Thr Lys Ile Asp Asp Ile 
1               5                   10                  15      


Pro Gly Leu Ser Asp Thr Ser Pro Asp Leu Ser Ser Arg Ser Ser Ser 
            20                  25                  30          


Arg Val Arg Phe Ser Ser Arg Glu Ser Val Pro Glu Thr Ser Arg Ser 
        35                  40                  45              


Glu Pro Met Ser Glu Met Ser Gly Ala Thr Thr Ser Leu Ala Thr Val 
    50                  55                  60                  


Ala Leu Asp Pro Pro Ser Asp Arg Thr Ser His Pro Gln Asp Val Ile 
65                  70                  75                  80  


Glu Asp Leu Ser Gln Asn Ser Ile Thr Gly Glu His Ser Gln Leu Leu 
                85                  90                  95      


Asp Asp Gly His Lys Lys Ala Arg Asn Ala Tyr Leu Asn Asn Ser Asn 
            100                 105                 110         


Tyr Glu Glu Gly Asp Glu Tyr Phe Asp Lys Asn Leu Ala Leu Phe Glu 
        115                 120                 125             


Glu Glu Met Asp Thr Arg Pro Lys Val Ser Ser Leu Leu Asn Arg Met 
    130                 135                 140                 


Ala Asn Tyr Thr Asn Leu Thr Gln Gly Ala Lys Glu His Glu Glu Ala 
145                 150                 155                 160 


Glu Asn Ile Thr Glu Gly Lys Lys Lys Pro Thr Lys Thr Pro Gln Met 
                165                 170                 175     


Gly Thr Phe Met Gly Val Tyr Leu Pro Cys Leu Gln Asn Ile Phe Gly 
            180                 185                 190         


Val Ile Leu Phe Leu Arg Leu Thr Trp Val Val Gly Thr Ala Gly Val 
        195                 200                 205             


Leu Gln Ala Phe Ala Ile Val Leu Ile Cys Cys Cys Cys Thr Met Leu 
    210                 215                 220                 


Thr Ala Ile Ser Met Ser Ala Ile Ala Thr Asn Gly Val Val Pro Ala 
225                 230                 235                 240 


Gly Gly Ser Tyr Phe Met Ile Ser Arg Ala Leu Gly Pro Glu Phe Gly 
                245                 250                 255     


Gly Ala Val Gly Leu Cys Phe Tyr Leu Gly Thr Thr Phe Ala Ala Ala 
            260                 265                 270         


Met Tyr Ile Leu Gly Ala Ile Glu Ile Phe Leu Val Tyr Ile Val Pro 
        275                 280                 285             


Arg Ala Ala Ile Phe His Ser Asp Asp Ala Leu Lys Glu Ser Ala Ala 
    290                 295                 300                 


Met Leu Asn Asn Met Arg Val Tyr Gly Thr Ala Phe Leu Val Leu Met 
305                 310                 315                 320 


Val Leu Val Val Phe Ile Gly Val Arg Tyr Val Asn Lys Phe Ala Ser 
                325                 330                 335     


Leu Phe Leu Ala Cys Val Ile Val Ser Ile Leu Ala Ile Tyr Ala Gly 
            340                 345                 350         


Ala Ile Lys Ser Ser Phe Ala Pro Pro His Phe Pro Val Cys Met Leu 
        355                 360                 365             


Gly Asn Arg Thr Leu Ser Ser Arg His Ile Asp Val Cys Ser Lys Thr 
    370                 375                 380                 


Lys Glu Ile Asn Asn Met Thr Val Pro Ser Lys Leu Trp Gly Phe Phe 
385                 390                 395                 400 


Cys Asn Ser Ser Gln Phe Phe Asn Ala Thr Cys Asp Glu Tyr Phe Val 
                405                 410                 415     


His Asn Asn Val Thr Ser Ile Gln Gly Ile Pro Gly Leu Ala Ser Gly 
            420                 425                 430         


Ile Ile Thr Glu Asn Leu Trp Ser Asn Tyr Leu Pro Lys Gly Glu Ile 
        435                 440                 445             


Ile Glu Lys Pro Ser Ala Lys Ser Ser Asp Val Leu Gly Ser Leu Asn 
    450                 455                 460                 


His Glu Tyr Val Leu Val Asp Ile Thr Thr Ser Phe Thr Leu Leu Val 
465                 470                 475                 480 


Gly Ile Phe Phe Pro Ser Val Thr Gly Ile Met Ala Gly Ser Asn Arg 
                485                 490                 495     


Ser Gly Asp Leu Lys Asp Ala Gln Lys Ser Ile Pro Ile Gly Thr Ile 
            500                 505                 510         


Leu Ala Ile Leu Thr Thr Ser Phe Val Tyr Leu Ser Asn Val Val Leu 
        515                 520                 525             


Phe Gly Ala Cys Ile Glu Gly Val Val Leu Arg Asp Lys Phe Gly Asp 
    530                 535                 540                 


Ala Val Lys Gly Asn Leu Val Val Gly Thr Leu Ser Trp Pro Ser Pro 
545                 550                 555                 560 


Trp Val Ile Val Ile Gly Ser Phe Phe Ser Thr Cys Gly Ala Gly Leu 
                565                 570                 575     


Gln Ser Leu Thr Gly Ala Pro Arg Leu Leu Gln Ala Ile Ala Lys Asp 
            580                 585                 590         


Asn Ile Ile Pro Phe Leu Arg Val Phe Gly His Ser Lys Ala Asn Gly 
        595                 600                 605             


Glu Pro Thr Trp Ala Leu Leu Leu Thr Ala Ala Ile Ala Glu Leu Gly 
    610                 615                 620                 


Ile Leu Ile Ala Ser Leu Asp Leu Val Ala Pro Ile Leu Ser Met Phe 
625                 630                 635                 640 


Phe Leu Met Cys Tyr Leu Phe Val Asn Leu Ala Cys Ala Leu Gln Thr 
                645                 650                 655     


Leu Leu Arg Thr Pro Asn Trp Arg Pro Arg Phe Arg Tyr Tyr His Trp 
            660                 665                 670         


Ala Leu Ser Phe Met Gly Met Ser Ile Cys Leu Ala Leu Met Phe Ile 
        675                 680                 685             


Ser Ser Trp Tyr Tyr Ala Ile Val Ala Met Val Ile Ala Gly Met Ile 
    690                 695                 700                 


Tyr Lys Tyr Ile Glu Tyr Gln Gly Ala Glu Lys Glu Trp Gly Asp Gly 
705                 710                 715                 720 


Ile Arg Gly Leu Ser Leu Ser Ala Ala Arg Phe Ala Leu Leu Arg Leu 
                725                 730                 735     


Glu Glu Gly Pro Pro His Thr Lys Asn Trp Arg Pro Gln Leu Leu Val 
            740                 745                 750         


Leu Leu Lys Leu Asp Glu Asp Leu His Val Lys His Pro Arg Leu Leu 
        755                 760                 765             


Thr Phe Ala Ser Gln Leu Lys Ala Gly Lys Gly Leu Thr Ile Val Gly 
    770                 775                 780                 


Ser Val Ile Val Gly Asn Phe Leu Glu Asn Tyr Gly Glu Ala Leu Ala 
785                 790                 795                 800 


Ala Glu Gln Thr Ile Lys His Leu Met Glu Ala Glu Lys Val Lys Gly 
                805                 810                 815     


Phe Cys Gln Leu Val Val Ala Ala Lys Leu Arg Glu Gly Ile Ser His 
            820                 825                 830         


Leu Ile Gln Ser Cys Gly Leu Gly Gly Met Lys His Asn Thr Val Val 
        835                 840                 845             


Met Gly Trp Pro Asn Gly Trp Arg Gln Ser Glu Asp Ala Arg Ala Trp 
    850                 855                 860                 


Lys Thr Phe Ile Gly Thr Val Arg Val Thr Thr Ala Ala His Leu Ala 
865                 870                 875                 880 


Leu Leu Val Ala Lys Asn Ile Ser Phe Phe Pro Ser Asn Val Glu Gln 
                885                 890                 895     


Phe Ser Glu Gly Asn Ile Asp Val Trp Trp Ile Val His Asp Gly Gly 
            900                 905                 910         


Met Leu Met Leu Leu Pro Phe Leu Leu Lys Gln His Lys Val Trp Arg 
        915                 920                 925             


Lys Cys Ser Ile Arg Ile Phe Thr Val Ala Gln Leu Glu Asp Asn Ser 
    930                 935                 940                 


Ile Gln Met Lys Lys Asp Leu Ala Thr Phe Leu Tyr His Leu Arg Ile 
945                 950                 955                 960 


Glu Ala Glu Val Glu Val Val Glu Met His Asp Ser Asp Ile Ser Ala 
                965                 970                 975     


Tyr Thr Tyr Glu Arg Thr Leu Met Met Glu Gln Arg Ser Gln Met Leu 
            980                 985                 990         


Arg His Met Arg Leu Ser Lys Thr  Glu Arg Asp Arg Glu  Ala Gln Leu 
        995                 1000                 1005             


Val Lys  Asp Arg Asn Ser Met  Leu Arg Leu Thr Ser  Ile Gly Ser 
    1010                 1015                 1020             


Asp Glu  Asp Glu Glu Thr Glu  Thr Tyr Gln Glu Lys  Val His Met 
    1025                 1030                 1035             


Thr Trp  Thr Lys Asp Lys Tyr  Met Ala Ser Arg Gly  Gln Lys Ala 
    1040                 1045                 1050             


Lys Ser  Met Glu Gly Phe Gln  Asp Leu Leu Asn Met  Arg Pro Asp 
    1055                 1060                 1065             


Gln Ser  Asn Val Arg Arg Met  His Thr Ala Val Lys  Leu Asn Glu 
    1070                 1075                 1080             


Val Ile  Val Asn Lys Ser His  Glu Ala Lys Leu Val  Leu Leu Asn 
    1085                 1090                 1095             


Met Pro  Gly Pro Pro Arg Asn  Pro Glu Gly Asp Glu  Asn Tyr Met 
    1100                 1105                 1110             


Glu Phe  Leu Glu Val Leu Thr  Glu Gly Leu Glu Arg  Val Leu Leu 
    1115                 1120                 1125             


Val Arg  Gly Gly Gly Ser Glu  Val Ile Thr Ile Tyr  Ser 
    1130                 1135                 1140     


<210>  899
<211>  1135
<212>  PRT
<213>  Homo sapiens

<400>  899

Met His Pro Pro Glu Thr Thr Thr Lys Met Ala Ser Val Arg Phe Met 
1               5                   10                  15      


Val Thr Pro Thr Lys Ile Asp Asp Ile Pro Gly Leu Ser Asp Thr Ser 
            20                  25                  30          


Pro Asp Leu Ser Ser Arg Ser Ser Ser Arg Val Arg Phe Ser Ser Arg 
        35                  40                  45              


Glu Ser Val Pro Glu Thr Ser Arg Ser Glu Pro Met Ser Glu Met Ser 
    50                  55                  60                  


Gly Ala Thr Thr Ser Leu Ala Thr Val Ala Leu Asp Pro Pro Ser Asp 
65                  70                  75                  80  


Arg Thr Ser His Pro Gln Asp Val Ile Glu Asp Asp Gly His Lys Lys 
                85                  90                  95      


Ala Arg Asn Ala Tyr Leu Asn Asn Ser Asn Tyr Glu Glu Gly Asp Glu 
            100                 105                 110         


Tyr Phe Asp Lys Asn Leu Ala Leu Phe Glu Glu Glu Met Asp Thr Arg 
        115                 120                 125             


Pro Lys Val Ser Ser Leu Leu Asn Arg Met Ala Asn Tyr Thr Asn Leu 
    130                 135                 140                 


Thr Gln Gly Ala Lys Glu His Glu Glu Ala Glu Asn Ile Thr Glu Gly 
145                 150                 155                 160 


Lys Lys Lys Pro Thr Lys Thr Pro Gln Met Gly Thr Phe Met Gly Val 
                165                 170                 175     


Tyr Leu Pro Cys Leu Gln Asn Ile Phe Gly Val Ile Leu Phe Leu Arg 
            180                 185                 190         


Leu Thr Trp Val Val Gly Thr Ala Gly Val Leu Gln Ala Phe Ala Ile 
        195                 200                 205             


Val Leu Ile Cys Cys Cys Cys Thr Met Leu Thr Ala Ile Ser Met Ser 
    210                 215                 220                 


Ala Ile Ala Thr Asn Gly Val Val Pro Ala Gly Gly Ser Tyr Phe Met 
225                 230                 235                 240 


Ile Ser Arg Ala Leu Gly Pro Glu Phe Gly Gly Ala Val Gly Leu Cys 
                245                 250                 255     


Phe Tyr Leu Gly Thr Thr Phe Ala Ala Ala Met Tyr Ile Leu Gly Ala 
            260                 265                 270         


Ile Glu Ile Phe Leu Val Tyr Ile Val Pro Arg Ala Ala Ile Phe His 
        275                 280                 285             


Ser Asp Asp Ala Leu Lys Glu Ser Ala Ala Met Leu Asn Asn Met Arg 
    290                 295                 300                 


Val Tyr Gly Thr Ala Phe Leu Val Leu Met Val Leu Val Val Phe Ile 
305                 310                 315                 320 


Gly Val Arg Tyr Val Asn Lys Phe Ala Ser Leu Phe Leu Ala Cys Val 
                325                 330                 335     


Ile Val Ser Ile Leu Ala Ile Tyr Ala Gly Ala Ile Lys Ser Ser Phe 
            340                 345                 350         


Ala Pro Pro His Phe Pro Val Cys Met Leu Gly Asn Arg Thr Leu Ser 
        355                 360                 365             


Ser Arg His Ile Asp Val Cys Ser Lys Thr Lys Glu Ile Asn Asn Met 
    370                 375                 380                 


Thr Val Pro Ser Lys Leu Trp Gly Phe Phe Cys Asn Ser Ser Gln Phe 
385                 390                 395                 400 


Phe Asn Ala Thr Cys Asp Glu Tyr Phe Val His Asn Asn Val Thr Ser 
                405                 410                 415     


Ile Gln Gly Ile Pro Gly Leu Ala Ser Gly Ile Ile Thr Glu Asn Leu 
            420                 425                 430         


Trp Ser Asn Tyr Leu Pro Lys Gly Glu Ile Ile Glu Lys Pro Ser Ala 
        435                 440                 445             


Lys Ser Ser Asp Val Leu Gly Ser Leu Asn His Glu Tyr Val Leu Val 
    450                 455                 460                 


Asp Ile Thr Thr Ser Phe Thr Leu Leu Val Gly Ile Phe Phe Pro Ser 
465                 470                 475                 480 


Val Thr Gly Ile Met Ala Gly Ser Asn Arg Ser Gly Asp Leu Lys Asp 
                485                 490                 495     


Ala Gln Lys Ser Ile Pro Ile Gly Thr Ile Leu Ala Ile Leu Thr Thr 
            500                 505                 510         


Ser Phe Val Tyr Leu Ser Asn Val Val Leu Phe Gly Ala Cys Ile Glu 
        515                 520                 525             


Gly Val Val Leu Arg Asp Lys Phe Gly Asp Ala Val Lys Gly Asn Leu 
    530                 535                 540                 


Val Val Gly Thr Leu Ser Trp Pro Ser Pro Trp Val Ile Val Ile Gly 
545                 550                 555                 560 


Ser Phe Phe Ser Thr Cys Gly Ala Gly Leu Gln Ser Leu Thr Gly Ala 
                565                 570                 575     


Pro Arg Leu Leu Gln Ala Ile Ala Lys Asp Asn Ile Ile Pro Phe Leu 
            580                 585                 590         


Arg Val Phe Gly His Ser Lys Ala Asn Gly Glu Pro Thr Trp Ala Leu 
        595                 600                 605             


Leu Leu Thr Ala Ala Ile Ala Glu Leu Gly Ile Leu Ile Ala Ser Leu 
    610                 615                 620                 


Asp Leu Val Ala Pro Ile Leu Ser Met Phe Phe Leu Met Cys Tyr Leu 
625                 630                 635                 640 


Phe Val Asn Leu Ala Cys Ala Leu Gln Thr Leu Leu Arg Thr Pro Asn 
                645                 650                 655     


Trp Arg Pro Arg Phe Arg Tyr Tyr His Trp Ala Leu Ser Phe Met Gly 
            660                 665                 670         


Met Ser Ile Cys Leu Ala Leu Met Phe Ile Ser Ser Trp Tyr Tyr Ala 
        675                 680                 685             


Ile Val Ala Met Val Ile Ala Gly Met Ile Tyr Lys Tyr Ile Glu Tyr 
    690                 695                 700                 


Gln Gly Ala Glu Lys Glu Trp Gly Asp Gly Ile Arg Gly Leu Ser Leu 
705                 710                 715                 720 


Ser Ala Ala Arg Phe Ala Leu Leu Arg Leu Glu Glu Gly Pro Pro His 
                725                 730                 735     


Thr Lys Asn Trp Arg Pro Gln Leu Leu Val Leu Leu Lys Leu Asp Glu 
            740                 745                 750         


Asp Leu His Val Lys His Pro Arg Leu Leu Thr Phe Ala Ser Gln Leu 
        755                 760                 765             


Lys Ala Gly Lys Gly Leu Thr Ile Val Gly Ser Val Ile Val Gly Asn 
    770                 775                 780                 


Phe Leu Glu Asn Tyr Gly Glu Ala Leu Ala Ala Glu Gln Thr Ile Lys 
785                 790                 795                 800 


His Leu Met Glu Ala Glu Lys Val Lys Gly Phe Cys Gln Leu Val Val 
                805                 810                 815     


Ala Ala Lys Leu Arg Glu Gly Ile Ser His Leu Ile Gln Ser Cys Gly 
            820                 825                 830         


Leu Gly Gly Met Lys His Asn Thr Val Val Met Gly Trp Pro Asn Gly 
        835                 840                 845             


Trp Arg Gln Ser Glu Asp Ala Arg Ala Trp Lys Thr Phe Ile Gly Thr 
    850                 855                 860                 


Val Arg Val Thr Thr Ala Ala His Leu Ala Leu Leu Val Ala Lys Asn 
865                 870                 875                 880 


Ile Ser Phe Phe Pro Ser Asn Val Glu Gln Phe Ser Glu Gly Asn Ile 
                885                 890                 895     


Asp Val Trp Trp Ile Val His Asp Gly Gly Met Leu Met Leu Leu Pro 
            900                 905                 910         


Phe Leu Leu Lys Gln His Lys Val Trp Arg Lys Cys Ser Ile Arg Ile 
        915                 920                 925             


Phe Thr Val Ala Gln Leu Glu Asp Asn Ser Ile Gln Met Lys Lys Asp 
    930                 935                 940                 


Leu Ala Thr Phe Leu Tyr His Leu Arg Ile Glu Ala Glu Val Glu Val 
945                 950                 955                 960 


Val Glu Met His Asp Ser Asp Ile Ser Ala Tyr Thr Tyr Glu Arg Thr 
                965                 970                 975     


Leu Met Met Glu Gln Arg Ser Gln Met Leu Arg His Met Arg Leu Ser 
            980                 985                 990         


Lys Thr Glu Arg Asp Arg Glu Ala  Gln Leu Val Lys Asp  Arg Asn Ser 
        995                 1000                 1005             


Met Leu  Arg Leu Thr Ser Ile  Gly Ser Asp Glu Asp  Glu Glu Thr 
    1010                 1015                 1020             


Glu Thr  Tyr Gln Glu Lys Val  His Met Thr Trp Thr  Lys Asp Lys 
    1025                 1030                 1035             


Tyr Met  Ala Ser Arg Gly Gln  Lys Ala Lys Ser Met  Glu Gly Phe 
    1040                 1045                 1050             


Gln Asp  Leu Leu Asn Met Arg  Pro Asp Gln Ser Asn  Val Arg Arg 
    1055                 1060                 1065             


Met His  Thr Ala Val Lys Leu  Asn Glu Val Ile Val  Asn Lys Ser 
    1070                 1075                 1080             


His Glu  Ala Lys Leu Val Leu  Leu Asn Met Pro Gly  Pro Pro Arg 
    1085                 1090                 1095             


Asn Pro  Glu Gly Asp Glu Asn  Tyr Met Glu Phe Leu  Glu Val Leu 
    1100                 1105                 1110             


Thr Glu  Gly Leu Glu Arg Val  Leu Leu Val Arg Gly  Gly Gly Ser 
    1115                 1120                 1125             


Glu Val  Ile Thr Ile Tyr Ser  
    1130                 1135 


<210>  900
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  900

Met Ala Ala Val Gly Ala Gly Gly Ser Thr Ala Ala Pro Gly Pro Gly 
1               5                   10                  15      


Ala Val Ser Ala Gly Ala Leu Glu Pro Gly Thr Ala Ser Ala Ala His 
            20                  25                  30          


Arg Arg Leu Lys Tyr Ile Ser Leu Ala Val Leu Val Val Gln Asn Ala 
        35                  40                  45              


Ser Leu Ile Leu Ser Ile Arg Tyr Ala Arg Thr Leu Pro Gly Asp Arg 
    50                  55                  60                  


Phe Phe Ala Thr Thr Ala Val Val Met Ala Glu Val Leu Lys Gly Leu 
65                  70                  75                  80  


Thr Cys Leu Leu Leu Leu Phe Ala Gln Lys Arg Gly Asn Val Lys His 
                85                  90                  95      


Leu Val Leu Phe Leu His Glu Ala Val Leu Val Gln Tyr Val Asp Thr 
            100                 105                 110         


Leu Lys Leu Ala Val Pro Ser Leu Ile Tyr Thr Leu Gln Asn Asn Leu 
        115                 120                 125             


Gln Tyr Val Ala Ile Ser Asn Leu Pro Ala Ala Thr Phe Gln Val Thr 
    130                 135                 140                 


Tyr Gln Leu Lys Ile Leu Thr Thr Ala Leu Phe Ser Val Leu Met Leu 
145                 150                 155                 160 


Asn Arg Ser Leu Ser Arg Leu Gln Trp Ala Ser Leu Leu Leu Leu Phe 
                165                 170                 175     


Thr Gly Val Ala Ile Val Gln Ala Gln Gln Ala Gly Gly Gly Gly Pro 
            180                 185                 190         


Arg Pro Leu Asp Gln Asn Pro Gly Ala Gly Leu Ala Ala Val Val Ala 
        195                 200                 205             


Ser Cys Leu Ser Ser Gly Phe Ala Gly Val Tyr Phe Glu Lys Ile Leu 
    210                 215                 220                 


Lys Gly Ser Ser Gly Ser Val Trp Leu Arg Asn Leu Gln Leu Gly Leu 
225                 230                 235                 240 


Phe Gly Thr Ala Leu Gly Leu Val Gly Leu Trp Trp Ala Glu Gly Thr 
                245                 250                 255     


Ala Val Ala Thr Arg Gly Phe Phe Phe Gly Tyr Thr Pro Ala Val Trp 
            260                 265                 270         


Gly Val Val Leu Asn Gln Ala Phe Gly Gly Leu Leu Val Ala Val Val 
        275                 280                 285             


Val Lys Tyr Ala Asp Asn Ile Leu Lys Gly Phe Ala Thr Ser Leu Ser 
    290                 295                 300                 


Ile Val Leu Ser Thr Val Ala Ser Ile Arg Leu Phe Gly Phe His Val 
305                 310                 315                 320 


Asp Pro Leu Phe Ala Leu Gly Ala Gly Leu Val Ile Gly Ala Val Tyr 
                325                 330                 335     


Leu Tyr Ser Leu Pro Arg Gly Ala Ala Lys Ala Ile Ala Ser Ala Ser 
            340                 345                 350         


Ala Ser Ala Ser Gly Pro Cys Val His Gln Gln Pro Pro Gly Gln Pro 
        355                 360                 365             


Pro Pro Pro Gln Leu Ser Ser His Arg Gly Asp Leu Ile Thr Glu Pro 
    370                 375                 380                 


Phe Leu Pro Lys Ser Val Leu Val Lys 
385                 390             


<210>  901
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  901

Met Gln Gly Gln Gly Arg Arg Arg Gly Thr Cys Lys Asp Ile Phe Cys 
1               5                   10                  15      


Ser Lys Met Ala Ser Tyr Leu Tyr Gly Val Leu Phe Ala Val Gly Leu 
            20                  25                  30          


Cys Ala Pro Ile Tyr Cys Val Ser Pro Ala Asn Ala Pro Ser Ala Tyr 
        35                  40                  45              


Pro Arg Pro Ser Ser Thr Lys Ser Thr Pro Ala Ser Gln Val Tyr Ser 
    50                  55                  60                  


Leu Asn Thr Asp Phe Ala Phe Arg Leu Tyr Arg Arg Leu Val Leu Glu 
65                  70                  75                  80  


Thr Pro Ser Gln Asn Ile Phe Phe Ser Pro Ala Arg Ile Asn Ser His 
                85                  90                  95      


Val Lys Lys Lys Thr Gln Gly Lys Val Val Asp Ile Ile Gln Gly Leu 
            100                 105                 110         


Asp Leu Leu Thr Ala Met Val Leu Val Asn His Ile Phe Phe Lys Ala 
        115                 120                 125             


Lys Trp Glu Lys Pro Phe His Pro Glu Tyr Thr Arg Lys Asn Phe Pro 
    130                 135                 140                 


Phe Leu Val Gly Glu Gln Val Thr Val His Val Pro Met Met His Gln 
145                 150                 155                 160 


Lys Glu Gln Phe Ala Phe Gly Val Asp Thr Glu Leu Asn Cys Phe Val 
                165                 170                 175     


Leu Gln Met Asp Tyr Lys Gly Asp Ala Val Ala Phe Phe Val Leu Pro 
            180                 185                 190         


Ser Lys Gly Lys Met Arg Gln Leu Glu Gln Ala Leu Ser Ala Arg Thr 
        195                 200                 205             


Leu Arg Lys Trp Ser His Ser Leu Gln Lys Arg Trp Ile Glu Val Phe 
    210                 215                 220                 


Ile Pro Arg Phe Ser Ile Ser Ala Ser Tyr Asn Leu Glu Thr Ile Leu 
225                 230                 235                 240 


Pro Lys Met Gly Ile Gln Asn Val Phe Asp Lys Asn Ala Asp Phe Ser 
                245                 250                 255     


Gly Ile Ala Lys Arg Asp Ser Leu Gln Val Ser Lys Ala Thr His Lys 
            260                 265                 270         


Ala Val Leu Asp Val Ser Glu Glu Gly Thr Glu Ala Thr Ala Ala Thr 
        275                 280                 285             


Thr Thr Lys Phe Ile Val Arg Ser Lys Asp Gly Pro Ser Tyr Phe Thr 
    290                 295                 300                 


Val Ser Phe Asn Arg Thr Phe Leu Met Met Ile Thr Asn Lys Ala Thr 
305                 310                 315                 320 


Asp Gly Ile Leu Phe Leu Gly Lys Val Glu Asn Pro Thr Lys Ser 
                325                 330                 335 


<210>  902
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  902

Met Glu Thr Thr Pro Leu Asn Ser Gln Lys Gln Leu Ser Ala Cys Glu 
1               5                   10                  15      


Asp Gly Glu Asp Cys Gln Glu Asn Gly Val Leu Gln Lys Val Val Pro 
            20                  25                  30          


Thr Pro Gly Asp Lys Val Glu Ser Gly Gln Ile Ser Asn Gly Tyr Ser 
        35                  40                  45              


Ala Val Pro Ser Pro Gly Ala Gly Asp Asp Thr Arg His Ser Ile Pro 
    50                  55                  60                  


Ala Thr Thr Thr Thr Leu Val Ala Glu Leu His Gln Gly Glu Arg Glu 
65                  70                  75                  80  


Thr Trp Gly Lys Lys Val Asp Phe Leu Leu Ser Val Ile Gly Tyr Ala 
                85                  90                  95      


Val Asp Leu Gly Asn Val Trp Arg Phe Pro Tyr Ile Cys Tyr Gln Asn 
            100                 105                 110         


Gly Gly Gly Ala Phe Leu Leu Pro Tyr Thr Ile Met Ala Ile Phe Gly 
        115                 120                 125             


Gly Ile Pro Leu Phe Tyr Met Glu Leu Ala Leu Gly Gln Tyr His Arg 
    130                 135                 140                 


Asn Gly Cys Ile Ser Ile Trp Arg Lys Ile Cys Pro Ile Phe Lys Gly 
145                 150                 155                 160 


Ile Gly Tyr Ala Ile Cys Ile Ile Ala Phe Tyr Ile Ala Ser Tyr Tyr 
                165                 170                 175     


Asn Thr Ile Met Ala Trp Ala Leu Tyr Tyr Leu Ile Ser Ser Phe Thr 
            180                 185                 190         


Asp Gln Leu Pro Trp Thr Ser Cys Lys Asn Ser Trp Asn Thr Gly Asn 
        195                 200                 205             


Cys Thr Asn Tyr Phe Ser Glu Asp Asn Ile Thr Trp Thr Leu His Ser 
    210                 215                 220                 


Thr Ser Pro Ala Glu Glu Phe Tyr Thr Arg His Val Leu Gln Ile His 
225                 230                 235                 240 


Arg Ser Lys Gly Leu Gln Asp Leu Gly Gly Ile Ser Trp Gln Leu Ala 
                245                 250                 255     


Leu Cys Ile Met Leu Ile Phe Thr Val Ile Tyr Phe Ser Ile Trp Lys 
            260                 265                 270         


Gly Val Lys Thr Ser Gly Lys Val Val Trp Val Thr Ala Thr Phe Pro 
        275                 280                 285             


Tyr Ile Ile Leu Ser Val Leu Leu Val Arg Gly Ala Thr Leu Pro Gly 
    290                 295                 300                 


Ala Trp Arg Gly Val Leu Phe Tyr Leu Lys Pro Asn Trp Gln Lys Leu 
305                 310                 315                 320 


Leu Glu Thr Gly Val Trp Ile Asp Ala Ala Ala Gln Ile Phe Phe Ser 
                325                 330                 335     


Leu Gly Pro Gly Phe Gly Val Leu Leu Ala Phe Ala Ser Tyr Asn Lys 
            340                 345                 350         


Phe Asn Asn Asn Cys Tyr Gln Asp Ala Leu Val Thr Ser Val Val Asn 
        355                 360                 365             


Cys Met Thr Ser Phe Val Ser Gly Phe Val Ile Phe Thr Val Leu Gly 
    370                 375                 380                 


Tyr Met Ala Glu Met Arg Asn Glu Asp Val Ser Glu Val Ala Lys Asp 
385                 390                 395                 400 


Ala Gly Pro Ser Leu Leu Phe Ile Thr Tyr Ala Glu Ala Ile Ala Asn 
                405                 410                 415     


Met Pro Ala Ser Thr Phe Phe Ala Ile Ile Phe Phe Leu Met Leu Ile 
            420                 425                 430         


Thr Leu Gly Leu Asp Ser Thr Phe Ala Gly Leu Glu Gly Val Ile Thr 
        435                 440                 445             


Ala Val Leu Asp Glu Phe Pro His Val Trp Ala Lys Arg Arg Glu Arg 
    450                 455                 460                 


Phe Val Leu Ala Val Val Ile Thr Cys Phe Phe Gly Ser Leu Val Thr 
465                 470                 475                 480 


Leu Thr Phe Gly Gly Ala Tyr Val Val Lys Leu Leu Glu Glu Tyr Ala 
                485                 490                 495     


Thr Gly Pro Ala Val Leu Thr Val Ala Leu Ile Glu Ala Val Ala Val 
            500                 505                 510         


Ser Trp Phe Tyr Gly Ile Thr Gln Phe Cys Arg Asp Val Lys Glu Met 
        515                 520                 525             


Leu Gly Phe Ser Pro Gly Trp Phe Trp Arg Ile Cys Trp Val Ala Ile 
    530                 535                 540                 


Ser Pro Leu Phe Leu Leu Phe Ile Ile Cys Ser Phe Leu Met Ser Pro 
545                 550                 555                 560 


Pro Gln Leu Arg Leu Phe Gln Tyr Asn Tyr Pro Tyr Trp Ser Ile Ile 
                565                 570                 575     


Leu Gly Tyr Cys Ile Gly Thr Ser Ser Phe Ile Cys Ile Pro Thr Tyr 
            580                 585                 590         


Ile Ala Tyr Arg Leu Ile Ile Thr Pro Gly Thr Phe Lys Glu Arg Ile 
        595                 600                 605             


Ile Lys Ser Ile Thr Pro Glu Thr Pro Thr Glu Ile Pro Cys Gly Asp 
    610                 615                 620                 


Ile Arg Leu Asn Ala Val 
625                 630 


<210>  903
<211>  701
<212>  PRT
<213>  Homo sapiens

<400>  903

Met Ala Arg Arg Gly Trp Arg Arg Ala Pro Leu Arg Arg Gly Val Gly 
1               5                   10                  15      


Ser Ser Pro Arg Ala Arg Arg Leu Met Arg Pro Leu Trp Leu Leu Leu 
            20                  25                  30          


Ala Val Gly Val Phe Asp Trp Ala Gly Ala Ser Asp Gly Gly Gly Gly 
        35                  40                  45              


Glu Ala Arg Ala Met Asp Glu Glu Ile Val Ser Glu Lys Gln Ala Glu 
    50                  55                  60                  


Glu Ser His Arg Gln Asp Ser Ala Asn Leu Leu Ile Phe Ile Leu Leu 
65                  70                  75                  80  


Leu Thr Leu Thr Ile Leu Thr Ile Trp Leu Phe Lys His Arg Arg Ala 
                85                  90                  95      


Arg Phe Leu His Glu Thr Gly Leu Ala Met Ile Tyr Gly Leu Leu Val 
            100                 105                 110         


Gly Leu Val Leu Arg Tyr Gly Ile His Val Pro Ser Asp Val Asn Asn 
        115                 120                 125             


Val Thr Leu Ser Cys Glu Val Gln Ser Ser Pro Thr Thr Leu Leu Val 
    130                 135                 140                 


Asn Val Ser Gly Lys Phe Tyr Glu Tyr Met Leu Lys Gly Glu Ile Ser 
145                 150                 155                 160 


Ser His Glu Leu Asn Asn Val Gln Asp Asn Glu Met Leu Arg Lys Val 
                165                 170                 175     


Thr Phe Asp Pro Glu Val Phe Phe Asn Ile Leu Leu Pro Pro Ile Ile 
            180                 185                 190         


Phe Tyr Ala Gly Tyr Ser Leu Lys Arg Arg His Phe Phe Arg Asn Leu 
        195                 200                 205             


Gly Ser Ile Leu Ala Tyr Ala Phe Leu Gly Thr Ala Ile Ser Cys Phe 
    210                 215                 220                 


Val Ile Gly Ser Ile Met Tyr Gly Cys Val Thr Leu Met Lys Val Thr 
225                 230                 235                 240 


Gly Gln Leu Ala Gly Asp Phe Tyr Phe Thr Asp Cys Leu Leu Phe Gly 
                245                 250                 255     


Ala Ile Val Ser Ala Thr Asp Pro Val Thr Val Leu Ala Ile Phe His 
            260                 265                 270         


Glu Leu Gln Val Asp Val Glu Leu Tyr Ala Leu Leu Phe Gly Glu Ser 
        275                 280                 285             


Val Leu Asn Asp Ala Val Ala Ile Val Leu Ser Ser Ser Ile Val Ala 
    290                 295                 300                 


Tyr Gln Pro Ala Gly Asp Asn Ser His Thr Phe Asp Val Thr Ala Met 
305                 310                 315                 320 


Phe Lys Ser Ile Gly Ile Phe Leu Gly Ile Phe Ser Gly Ser Phe Ala 
                325                 330                 335     


Met Gly Ala Ala Thr Gly Val Val Thr Ala Leu Val Thr Lys Phe Thr 
            340                 345                 350         


Lys Leu Arg Glu Phe Gln Leu Leu Glu Thr Gly Leu Phe Phe Leu Met 
        355                 360                 365             


Ser Trp Ser Thr Phe Leu Leu Ala Glu Ala Trp Gly Phe Thr Gly Val 
    370                 375                 380                 


Val Ala Val Leu Phe Cys Gly Ile Thr Gln Ala His Tyr Thr Tyr Asn 
385                 390                 395                 400 


Asn Leu Ser Thr Glu Ser Gln His Arg Thr Lys Gln Leu Phe Glu Leu 
                405                 410                 415     


Leu Asn Phe Leu Ala Glu Asn Phe Ile Phe Ser Tyr Met Gly Leu Thr 
            420                 425                 430         


Leu Phe Thr Phe Gln Asn His Val Phe Asn Pro Thr Phe Val Val Gly 
        435                 440                 445             


Ala Phe Val Ala Ile Phe Leu Gly Arg Ala Ala Asn Ile Tyr Pro Leu 
    450                 455                 460                 


Ser Leu Leu Leu Asn Leu Gly Arg Arg Ser Lys Ile Gly Ser Asn Phe 
465                 470                 475                 480 


Gln His Met Met Met Phe Ala Gly Leu Arg Gly Ala Met Ala Phe Ala 
                485                 490                 495     


Leu Ala Ile Arg Asp Thr Ala Thr Tyr Ala Arg Gln Met Met Phe Ser 
            500                 505                 510         


Thr Thr Leu Leu Ile Val Phe Phe Thr Val Trp Val Phe Gly Gly Gly 
        515                 520                 525             


Thr Thr Ala Met Leu Ser Cys Leu His Ile Arg Val Gly Val Asp Ser 
    530                 535                 540                 


Asp Gln Glu His Leu Gly Val Pro Glu Asn Glu Arg Arg Thr Thr Lys 
545                 550                 555                 560 


Ala Glu Ser Ala Trp Leu Phe Arg Met Trp Tyr Asn Phe Asp His Asn 
                565                 570                 575     


Tyr Leu Lys Pro Leu Leu Thr His Ser Gly Pro Pro Leu Thr Thr Thr 
            580                 585                 590         


Leu Pro Ala Cys Cys Gly Pro Ile Ala Arg Cys Leu Thr Ser Pro Gln 
        595                 600                 605             


Ala Tyr Glu Asn Gln Glu Gln Leu Lys Asp Asp Asp Ser Asp Leu Ile 
    610                 615                 620                 


Leu Asn Asp Gly Asp Ile Ser Leu Thr Tyr Gly Asp Ser Thr Val Asn 
625                 630                 635                 640 


Thr Glu Pro Ala Thr Ser Ser Ala Pro Arg Arg Phe Met Gly Asn Ser 
                645                 650                 655     


Ser Glu Asp Ala Leu Asp Arg Glu Leu Ala Phe Gly Asp His Glu Leu 
            660                 665                 670         


Val Ile Arg Gly Thr Arg Leu Val Leu Pro Met Asp Asp Ser Glu Pro 
        675                 680                 685             


Pro Leu Asn Leu Leu Asp Asn Thr Arg His Gly Pro Ala 
    690                 695                 700     


<210>  904
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  904

Met Ala His Val Arg His Phe Arg Thr Leu Val Ser Gly Phe Tyr Phe 
1               5                   10                  15      


Trp Glu Ala Ala Leu Leu Leu Ser Leu Val Ala Thr Lys Glu Thr Asp 
            20                  25                  30          


Ser Ala Arg Ser Arg Ser Ala Pro Met Ser Pro Ser Asp Phe Leu Asp 
        35                  40                  45              


Lys Leu Met Gly Arg Thr Ser Gly Tyr Asp Ala Arg Ile Arg Pro Asn 
    50                  55                  60                  


Phe Lys Gly Pro Pro Val Asn Val Thr Cys Asn Ile Phe Ile Asn Ser 
65                  70                  75                  80  


Phe Gly Ser Ile Ala Glu Thr Thr Met Asp Tyr Arg Val Asn Ile Phe 
                85                  90                  95      


Leu Arg Gln Lys Trp Asn Asp Pro Arg Leu Ala Tyr Ser Glu Tyr Pro 
            100                 105                 110         


Asp Asp Ser Leu Asp Leu Asp Pro Ser Met Leu Asp Ser Ile Trp Lys 
        115                 120                 125             


Pro Asp Leu Phe Phe Ala Asn Glu Lys Gly Ala Asn Phe His Glu Val 
    130                 135                 140                 


Thr Thr Asp Asn Lys Leu Leu Arg Ile Phe Lys Asn Gly Asn Val Leu 
145                 150                 155                 160 


Tyr Ser Ile Arg Leu Thr Leu Thr Leu Ser Cys Pro Met Asp Leu Lys 
                165                 170                 175     


Asn Phe Pro Met Asp Val Gln Thr Cys Ile Met Gln Leu Glu Ser Phe 
            180                 185                 190         


Gly Tyr Thr Met Asn Asp Leu Ile Phe Glu Trp Gln Asp Glu Ala Pro 
        195                 200                 205             


Val Gln Val Ala Glu Gly Leu Thr Leu Pro Gln Phe Leu Leu Lys Glu 
    210                 215                 220                 


Glu Lys Asp Leu Arg Tyr Cys Thr Lys His Tyr Asn Thr Gly Lys Phe 
225                 230                 235                 240 


Thr Cys Ile Glu Val Arg Phe His Leu Glu Arg Gln Met Gly Tyr Tyr 
                245                 250                 255     


Leu Ile Gln Met Tyr Ile Pro Ser Leu Leu Ile Val Ile Leu Ser Trp 
            260                 265                 270         


Val Ser Phe Trp Ile Asn Met Asp Ala Ala Pro Ala Arg Val Ala Leu 
        275                 280                 285             


Gly Ile Thr Thr Val Leu Thr Met Thr Thr Gln Ser Ser Gly Ser Arg 
    290                 295                 300                 


Ala Ser Leu Pro Lys Val Ser Tyr Val Lys Ala Ile Asp Ile Trp Met 
305                 310                 315                 320 


Ala Val Cys Leu Leu Phe Val Phe Ser Ala Leu Leu Glu Tyr Ala Ala 
                325                 330                 335     


Val Asn Phe Val Ser Arg Gln His Lys Glu Leu Leu Arg Phe Arg Arg 
            340                 345                 350         


Lys Arg Lys Asn Lys Asp Asp Glu Val Arg Glu Ser Arg Phe Ser Phe 
        355                 360                 365             


Thr Ala Tyr Gly Met Gly Pro Cys Leu Gln Ala Lys Asp Gly Met Thr 
    370                 375                 380                 


Pro Lys Gly Pro Asn His Pro Val Gln Val Met Pro Lys Ser Pro Asp 
385                 390                 395                 400 


Glu Met Arg Lys Val Phe Ile Asp Arg Ala Lys Lys Ile Asp Thr Ile 
                405                 410                 415     


Ser Arg Ala Cys Phe Pro Leu Ala Phe Leu Ile Phe Asn Ile Phe Tyr 
            420                 425                 430         


Trp Val Ile Tyr Lys Ile Leu Arg His Glu Asp Ile His Gln Gln Gln 
        435                 440                 445             


Asp 
    


<210>  905
<211>  977
<212>  PRT
<213>  Homo sapiens

<400>  905

Met Asp Ile Tyr Asp Thr Gln Thr Leu Gly Val Val Val Phe Gly Gly 
1               5                   10                  15      


Phe Met Val Val Ser Ala Ile Gly Ile Phe Leu Val Ser Thr Phe Ser 
            20                  25                  30          


Met Lys Glu Thr Ser Tyr Glu Glu Ala Leu Ala Asn Gln Arg Lys Glu 
        35                  40                  45              


Met Ala Lys Thr His His Gln Lys Val Glu Lys Lys Lys Lys Glu Lys 
    50                  55                  60                  


Thr Val Glu Lys Lys Gly Lys Thr Lys Lys Lys Glu Glu Lys Pro Asn 
65                  70                  75                  80  


Gly Lys Ile Pro Asp His Asp Pro Ala Pro Asn Val Thr Val Leu Leu 
                85                  90                  95      


Arg Glu Pro Val Arg Ala Pro Ala Val Ala Val Ala Pro Thr Pro Val 
            100                 105                 110         


Gln Pro Pro Ile Ile Val Ala Pro Val Ala Thr Val Pro Ala Met Pro 
        115                 120                 125             


Gln Glu Lys Leu Ala Ser Ser Pro Lys Asp Lys Lys Lys Lys Glu Lys 
    130                 135                 140                 


Lys Val Ala Lys Val Glu Pro Ala Val Ser Ser Val Val Asn Ser Ile 
145                 150                 155                 160 


Gln Val Leu Thr Ser Lys Ala Ala Ile Leu Glu Thr Ala Pro Lys Glu 
                165                 170                 175     


Gly Arg Asn Thr Asp Val Ala Gln Ser Pro Glu Ala Pro Lys Gln Glu 
            180                 185                 190         


Ala Pro Ala Lys Lys Lys Ser Gly Ser Lys Lys Lys Gly Pro Pro Asp 
        195                 200                 205             


Ala Asp Gly Pro Leu Tyr Leu Pro Tyr Lys Thr Leu Val Ser Thr Val 
    210                 215                 220                 


Gly Ser Met Val Phe Asn Glu Gly Glu Ala Gln Arg Leu Ile Glu Ile 
225                 230                 235                 240 


Leu Ser Glu Lys Ala Gly Ile Ile Gln Asp Thr Trp His Lys Ala Thr 
                245                 250                 255     


Gln Lys Gly Asp Pro Val Ala Ile Leu Lys Arg Gln Leu Glu Glu Lys 
            260                 265                 270         


Glu Lys Leu Leu Ala Thr Glu Gln Glu Asp Ala Ala Val Ala Lys Ser 
        275                 280                 285             


Lys Leu Arg Glu Leu Asn Lys Glu Met Ala Ala Glu Lys Ala Lys Ala 
    290                 295                 300                 


Ala Ala Gly Glu Ala Lys Val Lys Lys Gln Leu Val Ala Arg Glu Gln 
305                 310                 315                 320 


Glu Ile Thr Ala Val Gln Ala Arg Met Gln Ala Ser Tyr Arg Glu His 
                325                 330                 335     


Val Lys Glu Val Gln Gln Leu Gln Gly Lys Ile Arg Thr Leu Gln Glu 
            340                 345                 350         


Gln Leu Glu Asn Gly Pro Asn Thr Gln Leu Ala Arg Leu Gln Gln Glu 
        355                 360                 365             


Asn Ser Ile Leu Arg Asp Ala Leu Asn Gln Ala Thr Ser Gln Val Glu 
    370                 375                 380                 


Ser Lys Gln Asn Ala Glu Leu Ala Lys Leu Arg Gln Glu Leu Ser Lys 
385                 390                 395                 400 


Val Ser Lys Glu Leu Val Glu Lys Ser Glu Ala Val Arg Gln Asp Glu 
                405                 410                 415     


Gln Gln Arg Lys Ala Leu Glu Ala Lys Ala Ala Ala Phe Glu Lys Gln 
            420                 425                 430         


Val Leu Gln Leu Gln Ala Ser His Arg Glu Ser Glu Glu Ala Leu Gln 
        435                 440                 445             


Lys Arg Leu Asp Glu Val Ser Arg Glu Leu Cys His Thr Gln Ser Ser 
    450                 455                 460                 


His Ala Ser Leu Arg Ala Asp Ala Glu Lys Ala Gln Glu Gln Gln Gln 
465                 470                 475                 480 


Gln Met Ala Glu Leu His Ser Lys Leu Gln Ser Ser Glu Ala Glu Val 
                485                 490                 495     


Arg Ser Lys Cys Glu Glu Leu Ser Gly Leu His Gly Gln Leu Gln Glu 
            500                 505                 510         


Ala Arg Ala Glu Asn Ser Gln Leu Thr Glu Arg Ile Arg Ser Ile Glu 
        515                 520                 525             


Ala Leu Leu Glu Ala Gly Gln Ala Arg Asp Ala Gln Asp Val Gln Ala 
    530                 535                 540                 


Ser Gln Ala Glu Ala Asp Gln Gln Gln Thr Arg Leu Lys Glu Leu Glu 
545                 550                 555                 560 


Ser Gln Val Ser Gly Leu Glu Lys Glu Ala Ile Glu Leu Arg Glu Ala 
                565                 570                 575     


Val Glu Gln Gln Lys Val Lys Asn Asn Asp Leu Arg Glu Lys Asn Trp 
            580                 585                 590         


Lys Ala Met Glu Ala Leu Ala Thr Ala Glu Gln Ala Cys Lys Glu Lys 
        595                 600                 605             


Leu His Ser Leu Thr Gln Ala Lys Glu Glu Ser Glu Lys Gln Leu Cys 
    610                 615                 620                 


Leu Ile Glu Ala Gln Thr Met Glu Ala Leu Leu Ala Leu Leu Pro Glu 
625                 630                 635                 640 


Leu Ser Val Leu Ala Gln Gln Asn Tyr Thr Glu Trp Leu Gln Asp Leu 
                645                 650                 655     


Lys Glu Lys Gly Pro Thr Leu Leu Lys His Pro Pro Ala Pro Ala Glu 
            660                 665                 670         


Pro Ser Ser Asp Leu Ala Ser Lys Leu Arg Glu Ala Glu Glu Thr Gln 
        675                 680                 685             


Ser Thr Leu Gln Ala Glu Cys Asp Gln Tyr Arg Ser Ile Leu Ala Glu 
    690                 695                 700                 


Thr Glu Gly Met Leu Arg Asp Leu Gln Lys Ser Val Glu Glu Glu Glu 
705                 710                 715                 720 


Gln Val Trp Arg Ala Lys Val Gly Ala Ala Glu Glu Glu Leu Gln Lys 
                725                 730                 735     


Ser Arg Val Thr Val Lys His Leu Glu Glu Ile Val Glu Lys Leu Lys 
            740                 745                 750         


Gly Glu Leu Glu Ser Ser Asp Gln Val Arg Glu His Thr Ser His Leu 
        755                 760                 765             


Glu Ala Glu Leu Glu Lys His Met Ala Ala Ala Ser Ala Glu Cys Gln 
    770                 775                 780                 


Asn Tyr Ala Lys Glu Val Ala Gly Leu Arg Gln Leu Leu Leu Glu Ser 
785                 790                 795                 800 


Gln Ser Gln Leu Asp Ala Ala Lys Ser Glu Ala Gln Lys Gln Ser Asp 
                805                 810                 815     


Glu Leu Ala Leu Val Arg Gln Gln Leu Ser Glu Met Lys Ser His Val 
            820                 825                 830         


Glu Asp Gly Asp Ile Ala Gly Ala Pro Ala Ser Ser Pro Glu Ala Pro 
        835                 840                 845             


Pro Ala Glu Gln Asp Pro Val Gln Leu Lys Thr Gln Leu Glu Trp Thr 
    850                 855                 860                 


Glu Ala Ile Leu Glu Asp Glu Gln Thr Gln Arg Gln Lys Leu Thr Ala 
865                 870                 875                 880 


Glu Phe Glu Glu Ala Gln Thr Ser Ala Cys Arg Leu Gln Glu Glu Leu 
                885                 890                 895     


Glu Lys Leu Arg Thr Ala Gly Pro Leu Glu Ser Ser Glu Thr Glu Glu 
            900                 905                 910         


Ala Ser Gln Leu Lys Glu Arg Leu Glu Lys Glu Lys Lys Leu Thr Ser 
        915                 920                 925             


Asp Leu Gly Arg Ala Ala Thr Arg Leu Gln Glu Leu Leu Lys Thr Thr 
    930                 935                 940                 


Gln Glu Gln Leu Ala Arg Glu Lys Asp Thr Val Lys Lys Leu Gln Glu 
945                 950                 955                 960 


Gln Leu Glu Lys Ala Glu Asp Gly Ser Ser Ser Lys Glu Gly Thr Ser 
                965                 970                 975     


Val 
    


<210>  906
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  906

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Ala Pro Gln Ala Leu Gln Ser Tyr His Leu Ala Ala Glu 
            20                  25                  30          


Glu Gln Leu Ser Phe Arg Met Leu Gln Thr Ser Ser Phe Ala Asn His 
        35                  40                  45              


Ser Trp Ala His Ser Glu Gly Ser Gly Trp Leu Gly Asp Leu Gln Thr 
    50                  55                  60                  


His Gly Trp Asp Thr Val Leu Gly Thr Ile Arg Phe Leu Lys Pro Trp 
65                  70                  75                  80  


Ser His Gly Asn Phe Ser Lys Gln Glu Leu Lys Asn Leu Gln Ser Leu 
                85                  90                  95      


Phe Gln Leu Tyr Phe His Ser Phe Ile Gln Ile Val Gln Ala Ser Ala 
            100                 105                 110         


Gly Gln Phe Gln Leu Glu Tyr Pro Phe Glu Ile Gln Ile Leu Ala Gly 
        115                 120                 125             


Cys Arg Met Asn Ala Pro Gln Ile Phe Leu Asn Met Ala Tyr Gln Gly 
    130                 135                 140                 


Ser Asp Phe Leu Ser Phe Gln Gly Ile Ser Trp Glu Pro Ser Pro Gly 
145                 150                 155                 160 


Ala Gly Ile Arg Ala Gln Asn Ile Cys Lys Val Leu Asn Arg Tyr Leu 
                165                 170                 175     


Asp Ile Lys Glu Ile Leu Gln Ser Leu Leu Gly His Thr Cys Pro Arg 
            180                 185                 190         


Phe Leu Ala Gly Leu Met Glu Ala Gly Glu Ser Glu Leu Lys Arg Lys 
        195                 200                 205             


Val Lys Pro Glu Ala Trp Leu Ser Cys Gly Pro Ser Pro Gly Pro Gly 
    210                 215                 220                 


Arg Leu Gln Leu Val Cys His Val Ser Gly Phe Tyr Pro Lys Pro Val 
225                 230                 235                 240 


Trp Val Met Trp Met Arg Gly Glu Gln Glu Gln Arg Gly Thr Gln Arg 
                245                 250                 255     


Gly Asp Val Leu Pro Asn Ala Asp Glu Thr Trp Tyr Leu Arg Ala Thr 
            260                 265                 270         


Leu Asp Val Ala Ala Gly Glu Ala Ala Gly Leu Ser Cys Arg Val Lys 
        275                 280                 285             


His Ser Ser Leu Gly Gly His Asp Leu Ile Ile His Trp Gly Gly Tyr 
    290                 295                 300                 


Ser Ile Phe Leu Ile Leu Ile Cys Leu Thr Val Ile Val Thr Leu Val 
305                 310                 315                 320 


Ile Leu Val Val Val Asp Ser Arg Leu Lys Lys Gln Ser Pro Val Phe 
                325                 330                 335     


Leu Met Gly Ala Asn Thr Gln Asp Thr Lys Asn Ser Arg His Gln Phe 
            340                 345                 350         


Cys Leu Ala Gln Val Ser Trp Ile Lys Asn Arg Val Leu Lys Lys Trp 
        355                 360                 365             


Lys Thr Arg Leu Asn Gln Leu Trp 
    370                 375     


<210>  907
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  907

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Ala Pro Gln Ala Leu Gln Ser Tyr His Leu Ala Ala Glu 
            20                  25                  30          


Glu Gln Leu Ser Phe Arg Met Leu Gln Thr Ser Ser Phe Ala Asn His 
        35                  40                  45              


Ser Trp Ala His Ser Glu Gly Ser Gly Trp Leu Gly Asp Leu Gln Thr 
    50                  55                  60                  


His Gly Trp Asp Thr Val Leu Gly Thr Ile Arg Phe Leu Lys Pro Trp 
65                  70                  75                  80  


Ser His Gly Asn Phe Ser Lys Gln Glu Leu Lys Asn Leu Gln Ser Leu 
                85                  90                  95      


Phe Gln Leu Tyr Phe His Ser Phe Ile Gln Ile Val Gln Ala Ser Ala 
            100                 105                 110         


Gly Gln Phe Gln Leu Glu Tyr Pro Phe Glu Ile Gln Ile Leu Ala Gly 
        115                 120                 125             


Cys Arg Met Asn Ala Pro Gln Ile Phe Leu Asn Met Ala Tyr Gln Gly 
    130                 135                 140                 


Ser Asp Phe Leu Ser Phe Gln Gly Ile Ser Trp Glu Pro Ser Pro Gly 
145                 150                 155                 160 


Ala Gly Ile Arg Ala Gln Asn Ile Cys Lys Val Leu Asn Arg Tyr Leu 
                165                 170                 175     


Asp Ile Lys Glu Ile Leu Gln Ser Leu Leu Gly His Thr Cys Pro Arg 
            180                 185                 190         


Phe Leu Ala Gly Leu Met Glu Ala Gly Glu Ser Glu Leu Lys Arg Lys 
        195                 200                 205             


Val Lys Pro Glu Ala Trp Leu Ser Cys Gly Pro Ser Pro Gly Pro Gly 
    210                 215                 220                 


Arg Leu Gln Leu Val Cys His Val Ser Gly Phe Tyr Pro Lys Pro Val 
225                 230                 235                 240 


Trp Val Met Trp Met Arg Gly Glu Gln Glu Gln Arg Gly Thr Gln Arg 
                245                 250                 255     


Gly Asp Val Leu Pro Asn Ala Asp Glu Thr Trp Trp Ile Phe His Leu 
            260                 265                 270         


Ser His Pro Asp Leu Phe Asp Cys Asp Ser Tyr Pro Gly His Ile Gly 
        275                 280                 285             


Cys Ser 
    290 


<210>  908
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  908

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Ala Pro Gln Ala Leu Gln Ser Tyr His Leu Ala Ala Glu 
            20                  25                  30          


Glu Gln Leu Ser Phe Arg Met Leu Gln Thr Ser Ser Phe Ala Asn His 
        35                  40                  45              


Ser Trp Ala His Ser Glu Gly Ser Gly Trp Leu Gly Asp Leu Gln Thr 
    50                  55                  60                  


His Gly Trp Asp Thr Val Leu Gly Thr Ile Arg Phe Leu Lys Pro Trp 
65                  70                  75                  80  


Ser His Gly Asn Phe Ser Lys Gln Glu Leu Lys Asn Leu Gln Ser Leu 
                85                  90                  95      


Phe Gln Leu Tyr Phe His Ser Phe Ile Gln Ile Val Gln Ala Ser Ala 
            100                 105                 110         


Gly Gln Phe Gln Leu Glu Tyr Pro Phe Glu Ile Gln Ile Leu Ala Gly 
        115                 120                 125             


Cys Arg Met Asn Ala Pro Gln Ile Phe Leu Asn Met Ala Tyr Gln Gly 
    130                 135                 140                 


Ser Asp Phe Leu Ser Phe Gln Gly Ile Ser Trp Glu Pro Ser Pro Gly 
145                 150                 155                 160 


Ala Gly Ile Arg Ala Gln Asn Ile Cys Lys Val Leu Asn Arg Tyr Leu 
                165                 170                 175     


Asp Ile Lys Glu Ile Leu Gln Ser Leu Leu Gly His Thr Cys Pro Arg 
            180                 185                 190         


Phe Leu Ala Gly Leu Met Glu Ala Gly Glu Ser Glu Leu Lys Arg Lys 
        195                 200                 205             


Val Lys Pro Glu Ala Trp Leu Ser Cys Gly Pro Ser Pro Gly Pro Gly 
    210                 215                 220                 


Arg Leu Gln Leu Val Cys His Val Ser Gly Phe Tyr Pro Lys Pro Val 
225                 230                 235                 240 


Trp Val Met Trp Met Arg Gly Gly Tyr Ser Ile Phe Leu Ile Leu Ile 
                245                 250                 255     


Cys Leu Thr Val Ile Val Thr Leu Val Ile Leu Val Val Val Asp Ser 
            260                 265                 270         


Arg Leu Lys Lys Gln Ser Pro Val Phe Leu Met Gly Ala Asn Thr Gln 
        275                 280                 285             


Asp Thr Lys Asn Ser Arg His Gln Phe Cys Leu Ala Gln Val Ser Trp 
    290                 295                 300                 


Ile Lys Asn Arg Val Leu Lys Lys Trp Lys Thr Arg Leu Asn Gln Leu 
305                 310                 315                 320 


Trp 
    


<210>  909
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  909

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Val Lys Pro Glu Ala Trp Leu Ser Cys Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Gly Arg Leu Gln Leu Val Cys His Val Ser Gly Phe Tyr Pro 
        35                  40                  45              


Lys Pro Val Trp Val Met Trp Met Arg Gly Glu Gln Glu Gln Arg Gly 
    50                  55                  60                  


Thr Gln Arg Gly Asp Val Leu Pro Asn Ala Asp Glu Thr Trp Tyr Leu 
65                  70                  75                  80  


Arg Ala Thr Leu Asp Val Ala Ala Gly Glu Ala Ala Gly Leu Ser Cys 
                85                  90                  95      


Arg Val Lys His Ser Ser Leu Gly Gly His Asp Leu Ile Ile His Trp 
            100                 105                 110         


Gly Gly Tyr Ser Ile Phe Leu Ile Leu Ile Cys Leu Thr Val Ile Val 
        115                 120                 125             


Thr Leu Val Ile Leu Val Val Val Asp Ser Arg Leu Lys Lys Gln Ser 
    130                 135                 140                 


Pro Val Phe Leu Met Gly Ala Asn Thr Gln Asp Thr Lys Asn Ser Arg 
145                 150                 155                 160 


His Gln Phe Cys Leu Ala Gln Val Ser Trp Ile Lys Asn Arg Val Leu 
                165                 170                 175     


Lys Lys Trp Lys Thr Arg Leu Asn Gln Leu Trp 
            180                 185         


<210>  910
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  910

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Val Lys Pro Glu Ala Trp Leu Ser Cys Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Gly Arg Leu Gln Leu Val Cys His Val Ser Gly Phe Tyr Pro 
        35                  40                  45              


Lys Pro Val Trp Val Met Trp Met Arg Gly Glu Gln Glu Gln Arg Gly 
    50                  55                  60                  


Thr Gln Arg Gly Asp Val Leu Pro Asn Ala Asp Glu Thr Trp Trp Ile 
65                  70                  75                  80  


Phe His Leu Ser His Pro Asp Leu Phe Asp Cys Asp Ser Tyr Pro Gly 
                85                  90                  95      


His Ile Gly Cys Ser 
            100     


<210>  911
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  911

Met Asn Met Pro Gln Ser Leu Gly Asn Gln Pro Leu Pro Pro Glu Pro 
1               5                   10                  15      


Pro Ser Leu Gly Thr Pro Ala Glu Gly Pro Gly Thr Thr Ser Pro Pro 
            20                  25                  30          


Glu His Cys Trp Pro Val Arg Pro Thr Leu Arg Asn Glu Leu Asp Thr 
        35                  40                  45              


Phe Ser Val His Phe Tyr Ile Phe Phe Gly Pro Ser Val Ala Leu Pro 
    50                  55                  60                  


Pro Glu Arg Pro Ala Val Phe Ala Met Arg Leu Leu Pro Val Leu Asp 
65                  70                  75                  80  


Ser Gly Gly Val Leu Ser Leu Glu Leu Gln Leu Asn Ala Ser Ser Val 
                85                  90                  95      


Arg Gln Glu Asn Val Thr Val Phe Gly Cys Leu Thr His Glu Val Pro 
            100                 105                 110         


Leu Ser Leu Gly Asp Ala Ala Val Thr Cys Ser Lys Glu Ser Leu Ala 
        115                 120                 125             


Gly Phe Leu Leu Ser Val Ser Ala Thr Thr Arg Val Ala Arg Leu Arg 
    130                 135                 140                 


Ile Pro Phe Pro Gln Thr Gly Thr Trp Phe Leu Ala Leu Arg Ser Leu 
145                 150                 155                 160 


Cys Gly Val Gly Pro Arg Phe Val Arg Cys Arg Asn Ala Thr Ala Glu 
                165                 170                 175     


Val Arg Met Arg Thr Phe Leu Ser Pro Cys Val Asp Asp Cys Gly Pro 
            180                 185                 190         


Tyr Gly Gln Cys Lys Leu Leu Arg Thr His Asn Tyr Leu Tyr Ala Ala 
        195                 200                 205             


Cys Glu Cys Lys Ala Gly Trp Arg Gly Trp Gly Cys Thr Asp Ser Ala 
    210                 215                 220                 


Asp Ala Leu Thr Tyr Gly Phe Gln Leu Leu Ser Thr Leu Leu Leu Cys 
225                 230                 235                 240 


Leu Ser Asn Leu Met Phe Leu Pro Pro Val Val Leu Ala Ile Arg Ser 
                245                 250                 255     


Arg Tyr Val Leu Glu Ala Ala Val Tyr Thr Phe Thr Met Phe Phe Ser 
            260                 265                 270         


Thr Phe Tyr His Ala Cys Asp Gln Pro Gly Ile Val Val Phe Cys Ile 
        275                 280                 285             


Met Asp Tyr Asp Val Leu Gln Phe Cys Asp Phe Leu Gly Ser Leu Met 
    290                 295                 300                 


Ser Val Trp Val Thr Val Ile Ala Met Ala Arg Leu Gln Pro Val Val 
305                 310                 315                 320 


Lys Gln Val Leu Tyr Leu Leu Gly Ala Met Leu Leu Ser Met Ala Leu 
                325                 330                 335     


Gln Leu Asp Arg His Gly Leu Trp Asn Leu Leu Gly Pro Ser Leu Phe 
            340                 345                 350         


Ala Leu Gly Ile Leu Ala Thr Ala Trp Thr Val Arg Ser Val Arg Arg 
        355                 360                 365             


Arg His Cys Tyr Pro Pro Thr Trp Arg Arg Trp Leu Phe Tyr Leu Cys 
    370                 375                 380                 


Pro Gly Ser Leu Ile Ala Gly Ser Ala Val Leu Leu Tyr Ala Phe Val 
385                 390                 395                 400 


Glu Thr Arg Asp Asn Tyr Phe Tyr Ile His Ser Ile Trp His Met Leu 
                405                 410                 415     


Ile Ala Gly Ser Val Gly Phe Leu Leu Pro Pro Arg Ala Lys Thr Asp 
            420                 425                 430         


His Gly Val Pro Ser Gly Ala Arg Ala Arg Gly Cys Gly Tyr Gln Leu 
        435                 440                 445             


Cys Ile Asn Glu Gln Glu Glu Leu Gly Leu Val Gly Pro Gly Gly Ala 
    450                 455                 460                 


Thr Val Ser Ser Ile Cys Ala Ser 
465                 470         


<210>  912
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  912

Met Asn Met Pro Gln Ser Leu Gly Asn Gln Pro Leu Pro Pro Glu Pro 
1               5                   10                  15      


Pro Ser Leu Gly Thr Pro Ala Glu Gly Pro Gly Thr Thr Ser Pro Pro 
            20                  25                  30          


Glu His Cys Trp Pro Val Arg Pro Thr Leu Arg Asn Glu Leu Asp Thr 
        35                  40                  45              


Phe Ser Val His Phe Tyr Ile Phe Phe Gly Pro Ser Val Ala Leu Pro 
    50                  55                  60                  


Pro Glu Arg Pro Ala Val Phe Ala Met Arg Leu Leu Pro Val Leu Asp 
65                  70                  75                  80  


Ser Gly Gly Val Leu Ser Leu Glu Leu Gln Leu Asn Ala Ser Ser Val 
                85                  90                  95      


Arg Gln Glu Asn Val Thr Val Phe Gly Cys Leu Thr His Glu Val Pro 
            100                 105                 110         


Leu Ser Leu Gly Asp Ala Ala Val Thr Cys Ser Lys Glu Ser Leu Ala 
        115                 120                 125             


Gly Phe Leu Leu Ser Val Ser Ala Thr Thr Arg Val Ala Arg Leu Arg 
    130                 135                 140                 


Ile Pro Phe Pro Gln Thr Gly Thr Trp Phe Leu Ala Leu Arg Ser Leu 
145                 150                 155                 160 


Cys Gly Val Gly Pro Arg Phe Val Arg Cys Arg Asn Ala Thr Ala Glu 
                165                 170                 175     


Val Arg Met Arg Thr Phe Leu Ser Pro Cys Val Asp Asp Cys Gly Pro 
            180                 185                 190         


Tyr Gly Gln Cys Lys Leu Leu Arg Thr His Asn Tyr Leu Tyr Ala Ala 
        195                 200                 205             


Cys Glu Cys Lys Ala Gly Trp Arg Gly Trp Gly Cys Thr Asp Ser Ala 
    210                 215                 220                 


Asp Ala Leu Thr Tyr Gly Phe Gln Leu Leu Ser Thr Leu Leu Leu Cys 
225                 230                 235                 240 


Leu Ser Asn Leu Met Phe Leu Pro Pro Val Val Leu Ala Ile Arg Ser 
                245                 250                 255     


Arg Tyr Val Leu Glu Ala Ala Val Tyr Thr Phe Thr Met Phe Phe Ser 
            260                 265                 270         


Thr Phe Tyr His Ala Cys Asp Gln Pro Gly Ile Val Val Phe Cys Ile 
        275                 280                 285             


Met Asp Tyr Asp Val Leu Gln Phe Cys Asp Phe Leu Gly Ser Leu Met 
    290                 295                 300                 


Ser Val Trp Val Thr Val Ile Ala Met Ala Arg Leu Gln Pro Val Val 
305                 310                 315                 320 


Lys Gln Val Leu Tyr Leu Leu Gly Ala Met Leu Leu Ser Met Ala Leu 
                325                 330                 335     


Gln Leu Asp Arg His Gly Leu Trp Asn Leu Leu Gly Pro Ser Leu Phe 
            340                 345                 350         


Ala Leu Gly Ile Leu Ala Thr Ala Trp Thr Val Arg Ser Val Arg Arg 
        355                 360                 365             


Arg His Cys Tyr Pro Pro Thr Trp Arg Arg Trp Leu Phe Tyr Leu Cys 
    370                 375                 380                 


Pro Gly Ser Leu Ile Ala Gly Ser Ala Val Leu Leu Tyr Ala Phe Val 
385                 390                 395                 400 


Glu Thr Arg Asp Asn Tyr Phe Tyr Ile His Ser Ile Trp His Met Leu 
                405                 410                 415     


Ile Ala Gly Ser Val Gly Phe Leu Leu Pro Pro Arg Ala Lys Thr Asp 
            420                 425                 430         


His Gly Val Pro Ser Gly Ala Arg Ala Arg Gly Cys Gly Tyr Gln Leu 
        435                 440                 445             


Cys Ile Asn Glu Gln Glu Glu Leu Gly Leu Val Gly Pro Gly Gly Ala 
    450                 455                 460                 


Thr Val Ser Ser Ile Cys Ala Ser 
465                 470         


<210>  913
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  913

Met Asp Ser Pro Ser Leu Arg Glu Leu Gln Gln Pro Leu Leu Glu Gly 
1               5                   10                  15      


Thr Glu Cys Glu Thr Pro Ala Gln Lys Pro Gly Arg His Glu Leu Gly 
            20                  25                  30          


Ser Pro Leu Arg Glu Ile Ala Phe Ala Glu Ser Leu Arg Gly Leu Gln 
        35                  40                  45              


Phe Leu Ser Pro Pro Leu Pro Ser Val Ser Ala Gly Leu Gly Glu Pro 
    50                  55                  60                  


Arg Pro Pro Asp Val Glu Asp Met Ser Ser Ser Asp Ser Asp Ser Asp 
65                  70                  75                  80  


Trp Asp Gly Gly Ser Arg Leu Ser Pro Phe Leu Pro His Asp His Leu 
                85                  90                  95      


Gly Leu Ala Val Phe Ser Met Leu Cys Cys Phe Trp Pro Val Gly Ile 
            100                 105                 110         


Ala Ala Phe Cys Leu Ala Gln Lys His Pro Gln Cys Leu Thr Tyr Ser 
        115                 120                 125             


Arg Cys Tyr Val Ser Ala Phe Gly Ile His Ala 
    130                 135                 


<210>  914
<211>  1292
<212>  PRT
<213>  Homo sapiens

<400>  914

Met Lys Pro Ala Thr Gly Leu Trp Val Trp Val Ser Leu Leu Val Ala 
1               5                   10                  15      


Ala Gly Thr Val Gln Pro Ser Asp Ser Gln Ser Val Cys Ala Gly Thr 
            20                  25                  30          


Glu Asn Lys Leu Ser Ser Leu Ser Asp Leu Glu Gln Gln Tyr Arg Ala 
        35                  40                  45              


Leu Arg Lys Tyr Tyr Glu Asn Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Thr Ser Ile Glu His Asn Arg Asp Leu Ser Phe Leu Arg Ser Val 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Leu Asn Gln Phe Arg Tyr 
                85                  90                  95      


Leu Pro Leu Glu Asn Leu Arg Ile Ile Arg Gly Thr Lys Leu Tyr Glu 
            100                 105                 110         


Asp Arg Tyr Ala Leu Ala Ile Phe Leu Asn Tyr Arg Lys Asp Gly Asn 
        115                 120                 125             


Phe Gly Leu Gln Glu Leu Gly Leu Lys Asn Leu Thr Glu Ile Leu Asn 
    130                 135                 140                 


Gly Gly Val Tyr Val Asp Gln Asn Lys Phe Leu Cys Tyr Ala Asp Thr 
145                 150                 155                 160 


Ile His Trp Gln Asp Ile Val Arg Asn Pro Trp Pro Ser Asn Leu Thr 
                165                 170                 175     


Leu Val Ser Thr Asn Gly Ser Ser Gly Cys Gly Arg Cys His Lys Ser 
            180                 185                 190         


Cys Thr Gly Arg Cys Trp Gly Pro Thr Glu Asn His Cys Gln Thr Leu 
        195                 200                 205             


Thr Arg Thr Val Cys Ala Glu Gln Cys Asp Gly Arg Cys Tyr Gly Pro 
    210                 215                 220                 


Tyr Val Ser Asp Cys Cys His Arg Glu Cys Ala Gly Gly Cys Ser Gly 
225                 230                 235                 240 


Pro Lys Asp Thr Asp Cys Phe Ala Cys Met Asn Phe Asn Asp Ser Gly 
                245                 250                 255     


Ala Cys Val Thr Gln Cys Pro Gln Thr Phe Val Tyr Asn Pro Thr Thr 
            260                 265                 270         


Phe Gln Leu Glu His Asn Phe Asn Ala Lys Tyr Thr Tyr Gly Ala Phe 
        275                 280                 285             


Cys Val Lys Lys Cys Pro His Asn Phe Val Val Asp Ser Ser Ser Cys 
    290                 295                 300                 


Val Arg Ala Cys Pro Ser Ser Lys Met Glu Val Glu Glu Asn Gly Ile 
305                 310                 315                 320 


Lys Met Cys Lys Pro Cys Thr Asp Ile Cys Pro Lys Ala Cys Asp Gly 
                325                 330                 335     


Ile Gly Thr Gly Ser Leu Met Ser Ala Gln Thr Val Asp Ser Ser Asn 
            340                 345                 350         


Ile Asp Lys Phe Ile Asn Cys Thr Lys Ile Asn Gly Asn Leu Ile Phe 
        355                 360                 365             


Leu Val Thr Gly Ile His Gly Asp Pro Tyr Asn Ala Ile Glu Ala Ile 
    370                 375                 380                 


Asp Pro Glu Lys Leu Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly 
385                 390                 395                 400 


Phe Leu Asn Ile Gln Ser Trp Pro Pro Asn Met Thr Asp Phe Ser Val 
                405                 410                 415     


Phe Ser Asn Leu Val Thr Ile Gly Gly Arg Val Leu Tyr Ser Gly Leu 
            420                 425                 430         


Ser Leu Leu Ile Leu Lys Gln Gln Gly Ile Thr Ser Leu Gln Phe Gln 
        435                 440                 445             


Ser Leu Lys Glu Ile Ser Ala Gly Asn Ile Tyr Ile Thr Asp Asn Ser 
    450                 455                 460                 


Asn Leu Cys Tyr Tyr His Thr Ile Asn Trp Thr Thr Leu Phe Ser Thr 
465                 470                 475                 480 


Ile Asn Gln Arg Ile Val Ile Arg Asp Asn Arg Lys Ala Glu Asn Cys 
                485                 490                 495     


Thr Ala Glu Gly Met Val Cys Asn His Leu Cys Ser Ser Asp Gly Cys 
            500                 505                 510         


Trp Gly Pro Gly Pro Asp Gln Cys Leu Ser Cys Arg Arg Phe Ser Arg 
        515                 520                 525             


Gly Arg Ile Cys Ile Glu Ser Cys Asn Leu Tyr Asp Gly Glu Phe Arg 
    530                 535                 540                 


Glu Phe Glu Asn Gly Ser Ile Cys Val Glu Cys Asp Pro Gln Cys Glu 
545                 550                 555                 560 


Lys Met Glu Asp Gly Leu Leu Thr Cys His Gly Pro Gly Pro Asp Asn 
                565                 570                 575     


Cys Thr Lys Cys Ser His Phe Lys Asp Gly Pro Asn Cys Val Glu Lys 
            580                 585                 590         


Cys Pro Asp Gly Leu Gln Gly Ala Asn Ser Phe Ile Phe Lys Tyr Ala 
        595                 600                 605             


Asp Pro Asp Arg Glu Cys His Pro Cys His Pro Asn Cys Thr Gln Gly 
    610                 615                 620                 


Cys Asn Gly Pro Thr Ser His Asp Cys Ile Tyr Tyr Pro Trp Thr Gly 
625                 630                 635                 640 


His Ser Thr Leu Pro Gln His Ala Arg Thr Pro Leu Ile Ala Ala Gly 
                645                 650                 655     


Val Ile Gly Gly Leu Phe Ile Leu Val Ile Val Gly Leu Thr Phe Ala 
            660                 665                 670         


Val Tyr Val Arg Arg Lys Ser Ile Lys Lys Lys Arg Ala Leu Arg Arg 
        675                 680                 685             


Phe Leu Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Thr Ala 
    690                 695                 700                 


Pro Asn Gln Ala Gln Leu Arg Ile Leu Lys Glu Thr Glu Leu Lys Arg 
705                 710                 715                 720 


Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile 
                725                 730                 735     


Trp Val Pro Glu Gly Glu Thr Val Lys Ile Pro Val Ala Ile Lys Ile 
            740                 745                 750         


Leu Asn Glu Thr Thr Gly Pro Lys Ala Asn Val Glu Phe Met Asp Glu 
        755                 760                 765             


Ala Leu Ile Met Ala Ser Met Asp His Pro His Leu Val Arg Leu Leu 
    770                 775                 780                 


Gly Val Cys Leu Ser Pro Thr Ile Gln Leu Val Thr Gln Leu Met Pro 
785                 790                 795                 800 


His Gly Cys Leu Leu Glu Tyr Val His Glu His Lys Asp Asn Ile Gly 
                805                 810                 815     


Ser Gln Leu Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Met 
            820                 825                 830         


Tyr Leu Glu Glu Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn 
        835                 840                 845             


Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu 
    850                 855                 860                 


Ala Arg Leu Leu Glu Gly Asp Glu Lys Glu Tyr Asn Ala Asp Gly Gly 
865                 870                 875                 880 


Lys Met Pro Ile Lys Trp Met Ala Leu Glu Cys Ile His Tyr Arg Lys 
                885                 890                 895     


Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Ile Trp Glu 
            900                 905                 910         


Leu Met Thr Phe Gly Gly Lys Pro Tyr Asp Gly Ile Pro Thr Arg Glu 
        915                 920                 925             


Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile 
    930                 935                 940                 


Cys Thr Ile Asp Val Tyr Met Val Met Val Lys Cys Trp Met Ile Asp 
945                 950                 955                 960 


Ala Asp Ser Arg Pro Lys Phe Lys Glu Leu Ala Ala Glu Phe Ser Arg 
                965                 970                 975     


Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Asp Arg 
            980                 985                 990         


Met Lys Leu Pro Ser Pro Asn Asp  Ser Lys Phe Phe Gln  Asn Leu Leu 
        995                 1000                 1005             


Asp Glu  Glu Asp Leu Glu Asp  Met Met Asp Ala Glu  Glu Tyr Leu 
    1010                 1015                 1020             


Val Pro  Gln Ala Phe Asn Ile  Pro Pro Pro Ile Tyr  Thr Ser Arg 
    1025                 1030                 1035             


Ala Arg  Ile Asp Ser Asn Arg  Asn Gln Phe Val Tyr  Arg Asp Gly 
    1040                 1045                 1050             


Gly Phe  Ala Ala Glu Gln Gly  Val Ser Val Pro Tyr  Arg Ala Pro 
    1055                 1060                 1065             


Thr Ser  Thr Ile Pro Glu Ala  Pro Val Ala Gln Gly  Ala Thr Ala 
    1070                 1075                 1080             


Glu Ile  Phe Asp Asp Ser Cys  Cys Asn Gly Thr Leu  Arg Lys Pro 
    1085                 1090                 1095             


Val Ala  Pro His Val Gln Glu  Asp Ser Ser Thr Gln  Arg Tyr Ser 
    1100                 1105                 1110             


Ala Asp  Pro Thr Val Phe Ala  Pro Glu Arg Ser Pro  Arg Gly Glu 
    1115                 1120                 1125             


Leu Asp  Glu Glu Gly Tyr Met  Thr Pro Met Arg Asp  Lys Pro Lys 
    1130                 1135                 1140             


Gln Glu  Tyr Leu Asn Pro Val  Glu Glu Asn Pro Phe  Val Ser Arg 
    1145                 1150                 1155             


Arg Lys  Asn Gly Asp Leu Gln  Ala Leu Asp Asn Pro  Glu Tyr His 
    1160                 1165                 1170             


Asn Ala  Ser Asn Gly Pro Pro  Lys Ala Glu Asp Glu  Tyr Val Asn 
    1175                 1180                 1185             


Glu Pro  Leu Tyr Leu Asn Thr  Phe Ala Asn Thr Leu  Gly Lys Ala 
    1190                 1195                 1200             


Glu Tyr  Leu Lys Asn Asn Ile  Leu Ser Met Pro Glu  Lys Ala Lys 
    1205                 1210                 1215             


Lys Ala  Phe Asp Asn Pro Asp  Tyr Trp Asn His Ser  Leu Pro Pro 
    1220                 1225                 1230             


Arg Ser  Thr Leu Gln His Pro  Asp Tyr Leu Gln Glu  Tyr Ser Thr 
    1235                 1240                 1245             


Lys Tyr  Phe Tyr Lys Gln Asn  Gly Arg Ile Arg Pro  Ile Val Ala 
    1250                 1255                 1260             


Glu Asn  Pro Glu Tyr Leu Ser  Glu Phe Ser Leu Lys  Pro Gly Thr 
    1265                 1270                 1275             


Val Leu  Pro Pro Pro Pro Tyr  Arg His Arg Asn Thr  Val Val 
    1280                 1285                 1290         


<210>  915
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  915

Met Gly Pro Gly Pro Pro Ala Ala Gly Ala Ala Pro Ser Pro Arg Pro 
1               5                   10                  15      


Leu Ser Leu Val Ala Arg Leu Ser Tyr Ala Val Gly His Phe Leu Asn 
            20                  25                  30          


Asp Leu Cys Ala Ser Met Trp Phe Thr Tyr Leu Leu Leu Tyr Leu His 
        35                  40                  45              


Ser Val Arg Ala Tyr Ser Ser Arg Gly Ala Gly Leu Leu Leu Leu Leu 
    50                  55                  60                  


Gly Gln Val Ala Asp Gly Leu Cys Thr Pro Leu Val Gly Tyr Glu Ala 
65                  70                  75                  80  


Asp Arg Ala Ala Ser Cys Cys Ala Arg Tyr Gly Thr Val Cys Val Leu 
                85                  90                  95      


Leu Ser Phe Pro Phe Ile Phe Ser Pro Cys Leu Gly Cys Gly Ala Ala 
            100                 105                 110         


Thr Pro Glu Trp Ala Ala Leu Leu Tyr Tyr Gly Pro Phe Ile Val Ile 
        115                 120                 125             


Phe Gln Phe Gly Trp Ala Ser Thr Gln Ile Ser His Leu Ser Leu Ile 
    130                 135                 140                 


Pro Glu Leu Val Thr Asn Asp His Glu Lys Val Glu Leu Thr Ala Leu 
145                 150                 155                 160 


Arg Tyr Ala Phe Thr Val Val Ala Asn Ile Thr Val Tyr Gly Ala Ala 
                165                 170                 175     


Trp Leu Leu Leu His Leu Gln Gly Ser Ser Arg Val Glu Pro Thr Gln 
            180                 185                 190         


Asp Ile Ser Ile Ser Asp Gln Leu Gly Gly Gln Asp Val Pro Val Phe 
        195                 200                 205             


Arg Asn Leu Ser Leu Leu Val Val Gly Val Gly Ala Val Phe Ser Leu 
    210                 215                 220                 


Leu Phe His Leu Gly Thr Arg Glu Arg Arg Arg Pro His Ala Glu Glu 
225                 230                 235                 240 


Pro Gly Glu His Thr Pro Leu Leu Ala Pro Ala Thr Ala Gln Pro Leu 
                245                 250                 255     


Leu Leu Trp Lys His Trp Leu Arg Glu Pro Ala Phe Tyr Gln Val Gly 
            260                 265                 270         


Ile Leu Tyr Met Thr Thr Arg Leu Ile Val Asn Leu Ser Gln Thr Tyr 
        275                 280                 285             


Met Ala Met Tyr Leu Thr Tyr Ser Leu His Leu Pro Lys Lys Phe Ile 
    290                 295                 300                 


Ala Thr Ile Pro Leu Val Met Tyr Leu Ser Gly Phe Leu Ser Ser Phe 
305                 310                 315                 320 


Leu Met Lys Pro Ile Asn Lys Cys Ile Gly Arg Asn Met Thr Tyr Phe 
                325                 330                 335     


Ser Gly Leu Leu Val Ile Leu Ala Phe Ala Ala Trp Val Ala Leu Ala 
            340                 345                 350         


Glu Gly Leu Gly Val Ala Val Tyr Ala Ala Ala Val Leu Leu Gly Ala 
        355                 360                 365             


Gly Cys Ala Thr Ile Leu Val Thr Ser Leu Ala Met Thr Ala Asp Leu 
    370                 375                 380                 


Ile Gly Pro His Thr Asn Ser Gly Ala Phe Val Tyr Gly Ser Met Ser 
385                 390                 395                 400 


Phe Leu Asp Lys Val Ala Asn Gly Leu Ala Val Met Ala Ile Gln Ser 
                405                 410                 415     


Leu His Pro Cys Pro Ser Glu Leu Cys Cys Arg Ala Cys Val Ser Phe 
            420                 425                 430         


Tyr His Trp Ala Met Val Ala Val Thr Gly Gly Val Gly Val Ala Ala 
        435                 440                 445             


Ala Leu Cys Leu Cys Ser Leu Leu Leu Trp Pro Thr Arg Leu Arg Arg 
    450                 455                 460                 


Trp Asp Arg Asp Ala Arg Pro 
465                 470     


<210>  916
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  916

Met Ser Gly Ala Cys Thr Ser Tyr Val Ser Ala Glu Gln Glu Val Val 
1               5                   10                  15      


Arg Gly Phe Ser Cys Pro Arg Pro Gly Gly Glu Ala Ala Ala Val Phe 
            20                  25                  30          


Cys Cys Gly Phe Arg Asp His Lys Tyr Cys Cys Asp Asp Pro His Ser 
        35                  40                  45              


Phe Phe Pro Tyr Glu His Ser Tyr Met Trp Trp Leu Ser Ile Gly Ala 
    50                  55                  60                  


Leu Ile Gly Leu Ser Val Ala Ala Val Val Leu Leu Ala Phe Ile Val 
65                  70                  75                  80  


Thr Ala Cys Val Leu Cys Tyr Leu Phe Ile Ser Ser Lys Pro His Thr 
                85                  90                  95      


Lys Leu Asp Leu Gly Leu Ser Leu Gln Thr Ala Gly Pro Glu Glu Val 
            100                 105                 110         


Ser Pro Asp Cys Gln Gly Val Asn Thr Gly Met Ala Ala Glu Val Pro 
        115                 120                 125             


Lys Val Ser Pro Leu Gln Gln Ser Tyr Ser Cys Leu Asn Pro Gln Leu 
    130                 135                 140                 


Glu Ser Asn Glu Gly Gln Ala Val Asn Ser Lys Arg Leu Leu His His 
145                 150                 155                 160 


Cys Phe Met Ala Thr Val Thr Thr Ser Asp Ile Pro Gly Ser Pro Glu 
                165                 170                 175     


Glu Ala Ser Val Pro Asn Pro Asp Leu Cys Gly Pro Val Pro 
            180                 185                 190 


<210>  917
<211>  5033
<212>  PRT
<213>  Homo sapiens

<400>  917

Met Gly Asp Ala Glu Gly Glu Asp Glu Val Gln Phe Leu Arg Thr Asp 
1               5                   10                  15      


Asp Glu Val Val Leu Gln Cys Ser Ala Thr Val Leu Lys Glu Gln Leu 
            20                  25                  30          


Lys Leu Cys Leu Ala Ala Glu Gly Phe Gly Asn Arg Leu Cys Phe Leu 
        35                  40                  45              


Glu Pro Thr Ser Asn Ala Gln Asn Val Pro Pro Asp Leu Ala Ile Cys 
    50                  55                  60                  


Cys Phe Val Leu Glu Gln Ser Leu Ser Val Arg Ala Leu Gln Glu Met 
65                  70                  75                  80  


Leu Ala Asn Thr Val Glu Ala Gly Val Glu Ser Ser Gln Gly Gly Gly 
                85                  90                  95      


His Arg Thr Leu Leu Tyr Gly His Ala Ile Leu Leu Arg His Ala His 
            100                 105                 110         


Ser Arg Met Tyr Leu Ser Cys Leu Thr Thr Ser Arg Ser Met Thr Asp 
        115                 120                 125             


Lys Leu Ala Phe Asp Val Gly Leu Gln Glu Asp Ala Thr Gly Glu Ala 
    130                 135                 140                 


Cys Trp Trp Thr Met His Pro Ala Ser Lys Gln Arg Ser Glu Gly Glu 
145                 150                 155                 160 


Lys Val Arg Val Gly Asp Asp Ile Ile Leu Val Ser Val Ser Ser Glu 
                165                 170                 175     


Arg Tyr Leu His Leu Ser Thr Ala Ser Gly Glu Leu Gln Val Asp Ala 
            180                 185                 190         


Ser Phe Met Gln Thr Leu Trp Asn Met Asn Pro Ile Cys Ser Arg Cys 
        195                 200                 205             


Glu Glu Gly Phe Val Thr Gly Gly His Val Leu Arg Leu Phe His Gly 
    210                 215                 220                 


His Met Asp Glu Cys Leu Thr Ile Ser Pro Ala Asp Ser Asp Asp Gln 
225                 230                 235                 240 


Arg Arg Leu Val Tyr Tyr Glu Gly Gly Ala Val Cys Thr His Ala Arg 
                245                 250                 255     


Ser Leu Trp Arg Leu Glu Pro Leu Arg Ile Ser Trp Ser Gly Ser His 
            260                 265                 270         


Leu Arg Trp Gly Gln Pro Leu Arg Val Arg His Val Thr Thr Gly Gln 
        275                 280                 285             


Tyr Leu Ala Leu Thr Glu Asp Gln Gly Leu Val Val Val Asp Ala Ser 
    290                 295                 300                 


Lys Ala His Thr Lys Ala Thr Ser Phe Cys Phe Arg Ile Ser Lys Glu 
305                 310                 315                 320 


Lys Leu Asp Val Ala Pro Lys Arg Asp Val Glu Gly Met Gly Pro Pro 
                325                 330                 335     


Glu Ile Lys Tyr Gly Glu Ser Leu Cys Phe Val Gln His Val Ala Ser 
            340                 345                 350         


Gly Leu Trp Leu Thr Tyr Ala Ala Pro Asp Pro Lys Ala Leu Arg Leu 
        355                 360                 365             


Gly Val Leu Lys Lys Lys Ala Met Leu His Gln Glu Gly His Met Asp 
    370                 375                 380                 


Asp Ala Leu Ser Leu Thr Arg Cys Gln Gln Glu Glu Ser Gln Ala Ala 
385                 390                 395                 400 


Arg Met Ile His Ser Thr Asn Gly Leu Tyr Asn Gln Phe Ile Lys Ser 
                405                 410                 415     


Leu Asp Ser Phe Ser Gly Lys Pro Arg Gly Ser Gly Pro Pro Ala Gly 
            420                 425                 430         


Thr Ala Leu Pro Ile Glu Gly Val Ile Leu Ser Leu Gln Asp Leu Ile 
        435                 440                 445             


Ile Tyr Phe Glu Pro Pro Ser Glu Asp Leu Gln His Glu Glu Lys Gln 
    450                 455                 460                 


Ser Lys Leu Arg Ser Leu Arg Asn Arg Gln Ser Leu Phe Gln Glu Glu 
465                 470                 475                 480 


Gly Met Leu Ser Met Val Leu Asn Cys Ile Asp Arg Leu Asn Val Tyr 
                485                 490                 495     


Thr Thr Ala Ala His Phe Ala Glu Phe Ala Gly Glu Glu Ala Ala Glu 
            500                 505                 510         


Ser Trp Lys Glu Ile Val Asn Leu Leu Tyr Glu Leu Leu Ala Ser Leu 
        515                 520                 525             


Ile Arg Gly Asn Arg Ser Asn Cys Ala Leu Phe Ser Thr Asn Leu Asp 
    530                 535                 540                 


Trp Leu Val Ser Lys Leu Asp Arg Leu Glu Ala Ser Ser Gly Ile Leu 
545                 550                 555                 560 


Glu Val Leu Tyr Cys Val Leu Ile Glu Ser Pro Glu Val Leu Asn Ile 
                565                 570                 575     


Ile Gln Glu Asn His Ile Lys Ser Ile Ile Ser Leu Leu Asp Lys His 
            580                 585                 590         


Gly Arg Asn His Lys Val Leu Asp Val Leu Cys Ser Leu Cys Val Cys 
        595                 600                 605             


Asn Gly Val Ala Val Arg Ser Asn Gln Asp Leu Ile Thr Glu Asn Leu 
    610                 615                 620                 


Leu Pro Gly Arg Glu Leu Leu Leu Gln Thr Asn Leu Ile Asn Tyr Val 
625                 630                 635                 640 


Thr Ser Ile Arg Pro Asn Ile Phe Val Gly Arg Ala Glu Gly Thr Thr 
                645                 650                 655     


Gln Tyr Ser Lys Trp Tyr Phe Glu Val Met Val Asp Glu Val Thr Pro 
            660                 665                 670         


Phe Leu Thr Ala Gln Ala Thr His Leu Arg Val Gly Trp Ala Leu Thr 
        675                 680                 685             


Glu Gly Tyr Thr Pro Tyr Pro Gly Ala Gly Glu Gly Trp Gly Gly Asn 
    690                 695                 700                 


Gly Val Gly Asp Asp Leu Tyr Ser Tyr Gly Phe Asp Gly Leu His Leu 
705                 710                 715                 720 


Trp Thr Gly His Val Ala Arg Pro Val Thr Ser Pro Gly Gln His Leu 
                725                 730                 735     


Leu Ala Pro Glu Asp Val Ile Ser Cys Cys Leu Asp Leu Ser Val Pro 
            740                 745                 750         


Ser Ile Ser Phe Arg Ile Asn Gly Cys Pro Val Gln Gly Val Phe Glu 
        755                 760                 765             


Ser Phe Asn Leu Asp Gly Leu Phe Phe Pro Val Val Ser Phe Ser Ala 
    770                 775                 780                 


Gly Val Lys Val Arg Phe Leu Leu Gly Gly Arg His Gly Glu Phe Lys 
785                 790                 795                 800 


Phe Leu Pro Pro Pro Gly Tyr Ala Pro Cys His Glu Ala Val Leu Pro 
                805                 810                 815     


Arg Glu Arg Leu His Leu Glu Pro Ile Lys Glu Tyr Arg Arg Glu Gly 
            820                 825                 830         


Pro Arg Gly Pro His Leu Val Gly Pro Ser Arg Cys Leu Ser His Thr 
        835                 840                 845             


Asp Phe Val Pro Cys Pro Val Asp Thr Val Gln Ile Val Leu Pro Pro 
    850                 855                 860                 


His Leu Glu Arg Ile Arg Glu Lys Leu Ala Glu Asn Ile His Glu Leu 
865                 870                 875                 880 


Trp Ala Leu Thr Arg Ile Glu Gln Gly Trp Thr Tyr Gly Pro Val Arg 
                885                 890                 895     


Asp Asp Asn Lys Arg Leu His Pro Cys Leu Val Asp Phe His Ser Leu 
            900                 905                 910         


Pro Glu Pro Glu Arg Asn Tyr Asn Leu Gln Met Ser Gly Glu Thr Leu 
        915                 920                 925             


Lys Thr Leu Leu Ala Leu Gly Cys His Val Gly Met Ala Asp Glu Lys 
    930                 935                 940                 


Ala Glu Asp Asn Leu Lys Lys Thr Lys Leu Pro Lys Thr Tyr Met Met 
945                 950                 955                 960 


Ser Asn Gly Tyr Lys Pro Ala Pro Leu Asp Leu Ser His Val Arg Leu 
                965                 970                 975     


Thr Pro Ala Gln Thr Thr Leu Val Asp Arg Leu Ala Glu Asn Gly His 
            980                 985                 990         


Asn Val Trp Ala Arg Asp Arg Val  Gly Gln Gly Trp Ser  Tyr Ser Ala 
        995                 1000                 1005             


Val Gln  Asp Ile Pro Ala Arg  Arg Asn Pro Arg Leu  Val Pro Tyr 
    1010                 1015                 1020             


Arg Leu  Leu Asp Glu Ala Thr  Lys Arg Ser Asn Arg  Asp Ser Leu 
    1025                 1030                 1035             


Cys Gln  Ala Val Arg Thr Leu  Leu Gly Tyr Gly Tyr  Asn Ile Glu 
    1040                 1045                 1050             


Pro Pro  Asp Gln Glu Pro Ser  Gln Val Glu Asn Gln  Ser Arg Cys 
    1055                 1060                 1065             


Asp Arg  Val Arg Ile Phe Arg  Ala Glu Lys Ser Tyr  Thr Val Gln 
    1070                 1075                 1080             


Ser Gly  Arg Trp Tyr Phe Glu  Phe Glu Ala Val Thr  Thr Gly Glu 
    1085                 1090                 1095             


Met Arg  Val Gly Trp Ala Arg  Pro Glu Leu Arg Pro  Asp Val Glu 
    1100                 1105                 1110             


Leu Gly  Ala Asp Glu Leu Ala  Tyr Val Phe Asn Gly  His Arg Gly 
    1115                 1120                 1125             


Gln Arg  Trp His Leu Gly Ser  Glu Pro Phe Gly Arg  Pro Trp Gln 
    1130                 1135                 1140             


Pro Gly  Asp Val Val Gly Cys  Met Ile Asp Leu Thr  Glu Asn Thr 
    1145                 1150                 1155             


Ile Ile  Phe Thr Leu Asn Gly  Glu Val Leu Met Ser  Asp Ser Gly 
    1160                 1165                 1170             


Ser Glu  Thr Ala Phe Arg Glu  Ile Glu Ile Gly Asp  Gly Phe Leu 
    1175                 1180                 1185             


Pro Val  Cys Ser Leu Gly Pro  Gly Gln Val Gly His  Leu Asn Leu 
    1190                 1195                 1200             


Gly Gln  Asp Val Ser Ser Leu  Arg Phe Phe Ala Ile  Cys Gly Leu 
    1205                 1210                 1215             


Gln Glu  Gly Phe Glu Pro Phe  Ala Ile Asn Met Gln  Arg Pro Val 
    1220                 1225                 1230             


Thr Thr  Trp Phe Ser Lys Gly  Leu Pro Gln Phe Glu  Pro Val Pro 
    1235                 1240                 1245             


Leu Glu  His Pro His Tyr Glu  Val Ser Arg Val Asp  Gly Thr Val 
    1250                 1255                 1260             


Asp Thr  Pro Pro Cys Leu Arg  Leu Thr His Arg Thr  Trp Gly Ser 
    1265                 1270                 1275             


Gln Asn  Ser Leu Val Glu Met  Leu Phe Leu Arg Leu  Ser Leu Pro 
    1280                 1285                 1290             


Val Gln  Phe His Gln His Phe  Arg Cys Thr Ala Gly  Ala Thr Pro 
    1295                 1300                 1305             


Leu Ala  Pro Pro Gly Leu Gln  Pro Pro Ala Glu Asp  Glu Ala Arg 
    1310                 1315                 1320             


Ala Ala  Glu Pro Asp Pro Asp  Tyr Glu Asn Leu Arg  Arg Ser Ala 
    1325                 1330                 1335             


Gly Gly  Trp Ser Glu Ala Glu  Asn Gly Lys Glu Gly  Thr Ala Lys 
    1340                 1345                 1350             


Glu Gly  Ala Pro Gly Gly Thr  Pro Gln Ala Gly Gly  Glu Ala Gln 
    1355                 1360                 1365             


Pro Ala  Arg Ala Glu Asn Glu  Lys Asp Ala Thr Thr  Glu Lys Asn 
    1370                 1375                 1380             


Lys Lys  Arg Gly Phe Leu Phe  Lys Ala Lys Lys Val  Ala Met Met 
    1385                 1390                 1395             


Thr Gln  Pro Pro Ala Thr Pro  Thr Leu Pro Arg Leu  Pro His Asp 
    1400                 1405                 1410             


Val Val  Pro Ala Asp Asn Arg  Asp Asp Pro Glu Ile  Ile Leu Asn 
    1415                 1420                 1425             


Thr Thr  Thr Tyr Tyr Tyr Ser  Val Arg Val Phe Ala  Gly Gln Glu 
    1430                 1435                 1440             


Pro Ser  Cys Val Trp Ala Gly  Trp Val Thr Pro Asp  Tyr His Gln 
    1445                 1450                 1455             


His Asp  Met Ser Phe Asp Leu  Ser Lys Val Arg Val  Val Thr Val 
    1460                 1465                 1470             


Thr Met  Gly Asp Glu Gln Gly  Asn Val His Ser Ser  Leu Lys Cys 
    1475                 1480                 1485             


Ser Asn  Cys Tyr Met Val Trp  Gly Gly Asp Phe Val  Ser Pro Gly 
    1490                 1495                 1500             


Gln Gln  Gly Arg Ile Ser His  Thr Asp Leu Val Ile  Gly Cys Leu 
    1505                 1510                 1515             


Val Asp  Leu Ala Thr Gly Leu  Met Thr Phe Thr Ala  Asn Gly Lys 
    1520                 1525                 1530             


Glu Ser  Asn Thr Phe Phe Gln  Val Glu Pro Asn Thr  Lys Leu Phe 
    1535                 1540                 1545             


Pro Ala  Val Phe Val Leu Pro  Thr His Gln Asn Val  Ile Gln Phe 
    1550                 1555                 1560             


Glu Leu  Gly Lys Gln Lys Asn  Ile Met Pro Leu Ser  Ala Ala Met 
    1565                 1570                 1575             


Phe Gln  Ser Glu Arg Lys Asn  Pro Ala Pro Gln Cys  Pro Pro Arg 
    1580                 1585                 1590             


Leu Glu  Met Gln Met Leu Met  Pro Val Ser Trp Ser  Arg Met Pro 
    1595                 1600                 1605             


Asn His  Phe Leu Gln Val Glu  Thr Arg Arg Ala Gly  Glu Arg Leu 
    1610                 1615                 1620             


Gly Trp  Ala Val Gln Cys Gln  Glu Pro Leu Thr Met  Met Ala Leu 
    1625                 1630                 1635             


His Ile  Pro Glu Glu Asn Arg  Cys Met Asp Ile Leu  Glu Leu Ser 
    1640                 1645                 1650             


Glu Arg  Leu Asp Leu Gln Arg  Phe His Ser His Thr  Leu Arg Leu 
    1655                 1660                 1665             


Tyr Arg  Ala Val Cys Ala Leu  Gly Asn Asn Arg Val  Ala His Ala 
    1670                 1675                 1680             


Leu Cys  Ser His Val Asp Gln  Ala Gln Leu Leu His  Ala Leu Glu 
    1685                 1690                 1695             


Asp Ala  His Leu Pro Gly Pro  Leu Arg Ala Gly Tyr  Tyr Asp Leu 
    1700                 1705                 1710             


Leu Ile  Ser Ile His Leu Glu  Ser Ala Cys Arg Ser  Arg Arg Ser 
    1715                 1720                 1725             


Met Leu  Ser Glu Tyr Ile Val  Pro Leu Thr Pro Glu  Thr Arg Ala 
    1730                 1735                 1740             


Ile Thr  Leu Phe Pro Pro Gly  Arg Ser Thr Glu Asn  Gly His Pro 
    1745                 1750                 1755             


Arg His  Gly Leu Pro Gly Val  Gly Val Thr Thr Ser  Leu Arg Pro 
    1760                 1765                 1770             


Pro His  His Phe Ser Pro Pro  Cys Phe Val Ala Ala  Leu Pro Ala 
    1775                 1780                 1785             


Ala Gly  Ala Ala Glu Ala Pro  Ala Arg Leu Ser Pro  Ala Ile Pro 
    1790                 1795                 1800             


Leu Glu  Ala Leu Arg Asp Lys  Ala Leu Arg Met Leu  Gly Glu Ala 
    1805                 1810                 1815             


Val Arg  Asp Gly Gly Gln His  Ala Arg Asp Pro Val  Gly Gly Ser 
    1820                 1825                 1830             


Val Glu  Phe Gln Phe Val Pro  Val Leu Lys Leu Val  Ser Thr Leu 
    1835                 1840                 1845             


Leu Val  Met Gly Ile Phe Gly  Asp Glu Asp Val Lys  Gln Ile Leu 
    1850                 1855                 1860             


Lys Met  Ile Glu Pro Glu Val  Phe Thr Glu Glu Glu  Glu Glu Glu 
    1865                 1870                 1875             


Asp Glu  Glu Glu Glu Gly Glu  Glu Glu Asp Glu Glu  Glu Lys Glu 
    1880                 1885                 1890             


Glu Asp  Glu Glu Glu Thr Ala  Gln Glu Lys Glu Asp  Glu Glu Lys 
    1895                 1900                 1905             


Glu Glu  Glu Glu Ala Ala Glu  Gly Glu Lys Glu Glu  Gly Leu Glu 
    1910                 1915                 1920             


Glu Gly  Leu Leu Gln Met Lys  Leu Pro Glu Ser Val  Lys Leu Gln 
    1925                 1930                 1935             


Met Cys  His Leu Leu Glu Tyr  Phe Cys Asp Gln Glu  Leu Gln His 
    1940                 1945                 1950             


Arg Val  Glu Ser Leu Ala Ala  Phe Ala Glu Arg Tyr  Val Asp Lys 
    1955                 1960                 1965             


Leu Gln  Ala Asn Gln Arg Ser  Arg Tyr Gly Leu Leu  Ile Lys Ala 
    1970                 1975                 1980             


Phe Ser  Met Thr Ala Ala Glu  Thr Ala Arg Arg Thr  Arg Glu Phe 
    1985                 1990                 1995             


Arg Ser  Pro Pro Gln Glu Gln  Ile Asn Met Leu Leu  Gln Phe Lys 
    2000                 2005                 2010             


Asp Gly  Thr Asp Glu Glu Asp  Cys Pro Leu Pro Glu  Glu Ile Arg 
    2015                 2020                 2025             


Gln Asp  Leu Leu Asp Phe His  Gln Asp Leu Leu Ala  His Cys Gly 
    2030                 2035                 2040             


Ile Gln  Leu Asp Gly Glu Glu  Glu Glu Pro Glu Glu  Glu Thr Thr 
    2045                 2050                 2055             


Leu Gly  Ser Arg Leu Met Ser  Leu Leu Glu Lys Val  Arg Leu Val 
    2060                 2065                 2070             


Lys Lys  Lys Glu Glu Lys Pro  Glu Glu Glu Arg Ser  Ala Glu Glu 
    2075                 2080                 2085             


Ser Lys  Pro Arg Ser Leu Gln  Glu Leu Val Ser His  Met Val Val 
    2090                 2095                 2100             


Arg Trp  Ala Gln Glu Asp Phe  Val Gln Ser Pro Glu  Leu Val Arg 
    2105                 2110                 2115             


Ala Met  Phe Ser Leu Leu His  Arg Gln Tyr Asp Gly  Leu Gly Glu 
    2120                 2125                 2130             


Leu Leu  Arg Ala Leu Pro Arg  Ala Tyr Thr Ile Ser  Pro Ser Ser 
    2135                 2140                 2145             


Val Glu  Asp Thr Met Ser Leu  Leu Glu Cys Leu Gly  Gln Ile Arg 
    2150                 2155                 2160             


Ser Leu  Leu Ile Val Gln Met  Gly Pro Gln Glu Glu  Asn Leu Met 
    2165                 2170                 2175             


Ile Gln  Ser Ile Gly Asn Ile  Met Asn Asn Lys Val  Phe Tyr Gln 
    2180                 2185                 2190             


His Pro  Asn Leu Met Arg Ala  Leu Gly Met His Glu  Thr Val Met 
    2195                 2200                 2205             


Glu Val  Met Val Asn Val Leu  Gly Gly Gly Glu Ser  Lys Glu Ile 
    2210                 2215                 2220             


Arg Phe  Pro Lys Met Val Thr  Ser Cys Cys Arg Phe  Leu Cys Tyr 
    2225                 2230                 2235             


Phe Cys  Arg Ile Ser Arg Gln  Asn Gln Arg Ser Met  Phe Asp His 
    2240                 2245                 2250             


Leu Ser  Tyr Leu Leu Glu Asn  Ser Gly Ile Gly Leu  Gly Met Gln 
    2255                 2260                 2265             


Gly Ser  Thr Pro Leu Asp Val  Ala Ala Ala Ser Val  Ile Asp Asn 
    2270                 2275                 2280             


Asn Glu  Leu Ala Leu Ala Leu  Gln Glu Gln Asp Leu  Glu Lys Val 
    2285                 2290                 2295             


Val Ser  Tyr Leu Ala Gly Cys  Gly Leu Gln Ser Cys  Pro Met Leu 
    2300                 2305                 2310             


Val Ala  Lys Gly Tyr Pro Asp  Ile Gly Trp Asn Pro  Cys Gly Gly 
    2315                 2320                 2325             


Glu Arg  Tyr Leu Asp Phe Leu  Arg Phe Ala Val Phe  Val Asn Gly 
    2330                 2335                 2340             


Glu Ser  Val Glu Glu Asn Ala  Asn Val Val Val Arg  Leu Leu Ile 
    2345                 2350                 2355             


Arg Lys  Pro Glu Cys Phe Gly  Pro Ala Leu Arg Gly  Glu Gly Gly 
    2360                 2365                 2370             


Ser Gly  Leu Leu Ala Ala Ile  Glu Glu Ala Ile Arg  Ile Ser Glu 
    2375                 2380                 2385             


Asp Pro  Ala Arg Asp Gly Pro  Gly Ile Arg Arg Asp  Arg Arg Arg 
    2390                 2395                 2400             


Glu His  Phe Gly Glu Glu Pro  Pro Glu Glu Asn Arg  Val His Leu 
    2405                 2410                 2415             


Gly His  Ala Ile Met Ser Phe  Tyr Ala Ala Leu Ile  Asp Leu Leu 
    2420                 2425                 2430             


Gly Arg  Cys Ala Pro Glu Met  His Leu Ile Gln Ala  Gly Lys Gly 
    2435                 2440                 2445             


Glu Ala  Leu Arg Ile Arg Ala  Ile Leu Arg Ser Leu  Val Pro Leu 
    2450                 2455                 2460             


Glu Asp  Leu Val Gly Ile Ile  Ser Leu Pro Leu Gln  Ile Pro Thr 
    2465                 2470                 2475             


Leu Gly  Lys Asp Gly Ala Leu  Val Gln Pro Lys Met  Ser Ala Ser 
    2480                 2485                 2490             


Phe Val  Pro Asp His Lys Ala  Ser Met Val Leu Phe  Leu Asp Arg 
    2495                 2500                 2505             


Val Tyr  Gly Ile Glu Asn Gln  Asp Phe Leu Leu His  Val Leu Asp 
    2510                 2515                 2520             


Val Gly  Phe Leu Pro Asp Met  Arg Ala Ala Ala Ser  Leu Asp Thr 
    2525                 2530                 2535             


Ala Thr  Phe Ser Thr Thr Glu  Met Ala Leu Ala Leu  Asn Arg Tyr 
    2540                 2545                 2550             


Leu Cys  Leu Ala Val Leu Pro  Leu Ile Thr Lys Cys  Ala Pro Leu 
    2555                 2560                 2565             


Phe Ala  Gly Thr Glu His Arg  Ala Ile Met Val Asp  Ser Met Leu 
    2570                 2575                 2580             


His Thr  Val Tyr Arg Leu Ser  Arg Gly Arg Ser Leu  Thr Lys Ala 
    2585                 2590                 2595             


Gln Arg  Asp Val Ile Glu Asp  Cys Leu Met Ser Leu  Cys Arg Tyr 
    2600                 2605                 2610             


Ile Arg  Pro Ser Met Leu Gln  His Leu Leu Arg Arg  Leu Val Phe 
    2615                 2620                 2625             


Asp Val  Pro Ile Leu Asn Glu  Phe Ala Lys Met Pro  Leu Lys Leu 
    2630                 2635                 2640             


Leu Thr  Asn His Tyr Glu Arg  Cys Trp Lys Tyr Tyr  Cys Leu Pro 
    2645                 2650                 2655             


Thr Gly  Trp Ala Asn Phe Gly  Val Thr Ser Glu Glu  Glu Leu His 
    2660                 2665                 2670             


Leu Thr  Arg Lys Leu Phe Trp  Gly Ile Phe Asp Ser  Leu Ala His 
    2675                 2680                 2685             


Lys Lys  Tyr Asp Pro Glu Leu  Tyr Arg Met Ala Met  Pro Cys Leu 
    2690                 2695                 2700             


Cys Ala  Ile Ala Gly Ala Leu  Pro Pro Asp Tyr Val  Asp Ala Ser 
    2705                 2710                 2715             


Tyr Ser  Ser Lys Ala Glu Lys  Lys Ala Thr Val Asp  Ala Glu Gly 
    2720                 2725                 2730             


Asn Phe  Asp Pro Arg Pro Val  Glu Thr Leu Asn Val  Ile Ile Pro 
    2735                 2740                 2745             


Glu Lys  Leu Asp Ser Phe Ile  Asn Lys Phe Ala Glu  Tyr Thr His 
    2750                 2755                 2760             


Glu Lys  Trp Ala Phe Asp Lys  Ile Gln Asn Asn Trp  Ser Tyr Gly 
    2765                 2770                 2775             


Glu Asn  Ile Asp Glu Glu Leu  Lys Thr His Pro Met  Leu Arg Pro 
    2780                 2785                 2790             


Tyr Lys  Thr Phe Ser Glu Lys  Asp Lys Glu Ile Tyr  Arg Trp Pro 
    2795                 2800                 2805             


Ile Lys  Glu Ser Leu Lys Ala  Met Ile Ala Trp Glu  Trp Thr Ile 
    2810                 2815                 2820             


Glu Lys  Ala Arg Glu Gly Glu  Glu Glu Lys Thr Glu  Lys Lys Lys 
    2825                 2830                 2835             


Thr Arg  Lys Ile Ser Gln Ser  Ala Gln Thr Tyr Asp  Pro Arg Glu 
    2840                 2845                 2850             


Gly Tyr  Asn Pro Gln Pro Pro  Asp Leu Ser Ala Val  Thr Leu Ser 
    2855                 2860                 2865             


Arg Glu  Leu Gln Ala Met Ala  Glu Gln Leu Ala Glu  Asn Tyr His 
    2870                 2875                 2880             


Asn Thr  Trp Gly Arg Lys Lys  Lys Gln Glu Leu Glu  Ala Lys Gly 
    2885                 2890                 2895             


Gly Gly  Thr His Pro Leu Leu  Val Pro Tyr Asp Thr  Leu Thr Ala 
    2900                 2905                 2910             


Lys Glu  Lys Ala Arg Asp Arg  Glu Lys Ala Gln Glu  Leu Leu Lys 
    2915                 2920                 2925             


Phe Leu  Gln Met Asn Gly Tyr  Ala Val Thr Arg Gly  Leu Lys Asp 
    2930                 2935                 2940             


Met Glu  Leu Asp Ser Ser Ser  Ile Glu Lys Arg Phe  Ala Phe Gly 
    2945                 2950                 2955             


Phe Leu  Gln Gln Leu Leu Arg  Trp Met Asp Ile Ser  Gln Glu Phe 
    2960                 2965                 2970             


Ile Ala  His Leu Glu Ala Val  Val Ser Ser Gly Arg  Val Glu Lys 
    2975                 2980                 2985             


Ser Pro  His Glu Gln Glu Ile  Lys Phe Phe Ala Lys  Ile Leu Leu 
    2990                 2995                 3000             


Pro Leu  Ile Asn Gln Tyr Phe  Thr Asn His Cys Leu  Tyr Phe Leu 
    3005                 3010                 3015             


Ser Thr  Pro Ala Lys Val Leu  Gly Ser Gly Gly His  Ala Ser Asn 
    3020                 3025                 3030             


Lys Glu  Lys Glu Met Ile Thr  Ser Leu Phe Cys Lys  Leu Ala Ala 
    3035                 3040                 3045             


Leu Val  Arg His Arg Val Ser  Leu Phe Gly Thr Asp  Ala Pro Ala 
    3050                 3055                 3060             


Val Val  Asn Cys Leu His Ile  Leu Ala Arg Ser Leu  Asp Ala Arg 
    3065                 3070                 3075             


Thr Val  Met Lys Ser Gly Pro  Glu Ile Val Lys Ala  Gly Leu Arg 
    3080                 3085                 3090             


Ser Phe  Phe Glu Ser Ala Ser  Glu Asp Ile Glu Lys  Met Val Glu 
    3095                 3100                 3105             


Asn Leu  Arg Leu Gly Lys Val  Ser Gln Ala Arg Thr  Gln Val Lys 
    3110                 3115                 3120             


Gly Val  Gly Gln Asn Leu Thr  Tyr Thr Thr Val Ala  Leu Leu Pro 
    3125                 3130                 3135             


Val Leu  Thr Thr Leu Phe Gln  His Ile Ala Gln His  Gln Phe Gly 
    3140                 3145                 3150             


Asp Asp  Val Ile Leu Asp Asp  Val Gln Val Ser Cys  Tyr Arg Thr 
    3155                 3160                 3165             


Leu Cys  Ser Ile Tyr Ser Leu  Gly Thr Thr Lys Asn  Thr Tyr Val 
    3170                 3175                 3180             


Glu Lys  Leu Arg Pro Ala Leu  Gly Glu Cys Leu Ala  Arg Leu Ala 
    3185                 3190                 3195             


Ala Ala  Met Pro Val Ala Phe  Leu Glu Pro Gln Leu  Asn Glu Tyr 
    3200                 3205                 3210             


Asn Ala  Cys Ser Val Tyr Thr  Thr Lys Ser Pro Arg  Glu Arg Ala 
    3215                 3220                 3225             


Ile Leu  Gly Leu Pro Asn Ser  Val Glu Glu Met Cys  Pro Asp Ile 
    3230                 3235                 3240             


Pro Val  Leu Glu Arg Leu Met  Ala Asp Ile Gly Gly  Leu Ala Glu 
    3245                 3250                 3255             


Ser Gly  Ala Arg Tyr Thr Glu  Met Pro His Val Ile  Glu Ile Thr 
    3260                 3265                 3270             


Leu Pro  Met Leu Cys Ser Tyr  Leu Pro Arg Trp Trp  Glu Arg Gly 
    3275                 3280                 3285             


Pro Glu  Ala Pro Pro Ser Ala  Leu Pro Ala Gly Ala  Pro Pro Pro 
    3290                 3295                 3300             


Cys Thr  Ala Val Thr Ser Asp  His Leu Asn Ser Leu  Leu Gly Asn 
    3305                 3310                 3315             


Ile Leu  Arg Ile Ile Val Asn  Asn Leu Gly Ile Asp  Glu Ala Ser 
    3320                 3325                 3330             


Trp Met  Lys Arg Leu Ala Val  Phe Ala Gln Pro Ile  Val Ser Arg 
    3335                 3340                 3345             


Ala Arg  Pro Glu Leu Leu Gln  Ser His Phe Ile Pro  Thr Ile Gly 
    3350                 3355                 3360             


Arg Leu  Arg Lys Arg Ala Gly  Lys Val Val Ser Glu  Glu Glu Gln 
    3365                 3370                 3375             


Leu Arg  Leu Glu Ala Lys Ala  Glu Ala Gln Glu Gly  Glu Leu Leu 
    3380                 3385                 3390             


Val Arg  Asp Glu Phe Ser Val  Leu Cys Arg Asp Leu  Tyr Ala Leu 
    3395                 3400                 3405             


Tyr Pro  Leu Leu Ile Arg Tyr  Val Asp Asn Asn Arg  Ala Gln Trp 
    3410                 3415                 3420             


Leu Thr  Glu Pro Asn Pro Ser  Ala Glu Glu Leu Phe  Arg Met Val 
    3425                 3430                 3435             


Gly Glu  Ile Phe Ile Tyr Trp  Ser Lys Ser His Asn  Phe Lys Arg 
    3440                 3445                 3450             


Glu Glu  Gln Asn Phe Val Val  Gln Asn Glu Ile Asn  Asn Met Ser 
    3455                 3460                 3465             


Phe Leu  Thr Ala Asp Asn Lys  Ser Lys Met Ala Lys  Ser Gly Gly 
    3470                 3475                 3480             


Ser Asp  Gln Glu Arg Thr Lys  Lys Lys Arg Arg Gly  Asp Arg Tyr 
    3485                 3490                 3495             


Ser Val  Gln Thr Ser Leu Ile  Val Ala Thr Leu Lys  Lys Met Leu 
    3500                 3505                 3510             


Pro Ile  Gly Leu Asn Met Cys  Ala Pro Thr Asp Gln  Asp Leu Ile 
    3515                 3520                 3525             


Thr Leu  Ala Lys Thr Arg Tyr  Ala Leu Lys Asp Thr  Asp Glu Glu 
    3530                 3535                 3540             


Val Arg  Glu Phe Leu His Asn  Asn Leu His Leu Gln  Gly Lys Val 
    3545                 3550                 3555             


Glu Gly  Ser Pro Ser Leu Arg  Trp Gln Met Ala Leu  Tyr Arg Gly 
    3560                 3565                 3570             


Val Pro  Gly Arg Glu Glu Asp  Ala Asp Asp Pro Glu  Lys Ile Val 
    3575                 3580                 3585             


Arg Arg  Val Gln Glu Val Ser  Ala Val Leu Tyr Tyr  Leu Asp Gln 
    3590                 3595                 3600             


Thr Glu  His Pro Tyr Lys Ser  Lys Lys Ala Val Trp  His Lys Leu 
    3605                 3610                 3615             


Leu Ser  Lys Gln Arg Arg Arg  Ala Val Val Ala Cys  Phe Arg Met 
    3620                 3625                 3630             


Thr Pro  Leu Tyr Asn Leu Pro  Thr His Arg Ala Cys  Asn Met Phe 
    3635                 3640                 3645             


Leu Glu  Ser Tyr Lys Ala Ala  Trp Ile Leu Thr Glu  Asp His Ser 
    3650                 3655                 3660             


Phe Glu  Asp Arg Met Ile Asp  Asp Leu Ser Lys Ala  Gly Glu Gln 
    3665                 3670                 3675             


Glu Glu  Glu Glu Glu Glu Val  Glu Glu Lys Lys Pro  Asp Pro Leu 
    3680                 3685                 3690             


His Gln  Leu Val Leu His Phe  Ser Arg Thr Ala Leu  Thr Glu Lys 
    3695                 3700                 3705             


Ser Lys  Leu Asp Glu Asp Tyr  Leu Tyr Met Ala Tyr  Ala Asp Ile 
    3710                 3715                 3720             


Met Ala  Lys Ser Cys His Leu  Glu Glu Gly Gly Glu  Asn Gly Glu 
    3725                 3730                 3735             


Ala Glu  Glu Glu Val Glu Val  Ser Phe Glu Glu Lys  Gln Met Glu 
    3740                 3745                 3750             


Lys Gln  Arg Leu Leu Tyr Gln  Gln Ala Arg Leu His  Thr Arg Gly 
    3755                 3760                 3765             


Ala Ala  Glu Met Val Leu Gln  Met Ile Ser Ala Cys  Lys Gly Glu 
    3770                 3775                 3780             


Thr Gly  Ala Met Val Ser Ser  Thr Leu Lys Leu Gly  Ile Ser Ile 
    3785                 3790                 3795             


Leu Asn  Gly Gly Asn Ala Glu  Val Gln Gln Lys Met  Leu Asp Tyr 
    3800                 3805                 3810             


Leu Lys  Asp Lys Lys Glu Val  Gly Phe Phe Gln Ser  Ile Gln Ala 
    3815                 3820                 3825             


Leu Met  Gln Thr Cys Ser Val  Leu Asp Leu Asn Ala  Phe Glu Arg 
    3830                 3835                 3840             


Gln Asn  Lys Ala Glu Gly Leu  Gly Met Val Asn Glu  Asp Gly Thr 
    3845                 3850                 3855             


Val Ile  Asn Arg Gln Asn Gly  Glu Lys Val Met Ala  Asp Asp Glu 
    3860                 3865                 3870             


Phe Thr  Gln Asp Leu Phe Arg  Phe Leu Gln Leu Leu  Cys Glu Gly 
    3875                 3880                 3885             


His Asn  Asn Asp Phe Gln Asn  Tyr Leu Arg Thr Gln  Thr Gly Asn 
    3890                 3895                 3900             


Thr Thr  Thr Ile Asn Ile Ile  Ile Cys Thr Val Asp  Tyr Leu Leu 
    3905                 3910                 3915             


Arg Leu  Gln Glu Ser Ile Ser  Asp Phe Tyr Trp Tyr  Tyr Ser Gly 
    3920                 3925                 3930             


Lys Asp  Val Ile Glu Glu Gln  Gly Lys Arg Asn Phe  Ser Lys Ala 
    3935                 3940                 3945             


Met Ser  Val Ala Lys Gln Val  Phe Asn Ser Leu Thr  Glu Tyr Ile 
    3950                 3955                 3960             


Gln Gly  Pro Cys Thr Gly Asn  Gln Gln Ser Leu Ala  His Ser Arg 
    3965                 3970                 3975             


Leu Trp  Asp Ala Val Val Gly  Phe Leu His Val Phe  Ala His Met 
    3980                 3985                 3990             


Met Met  Lys Leu Ala Gln Asp  Ser Ser Gln Ile Glu  Leu Leu Lys 
    3995                 4000                 4005             


Glu Leu  Leu Asp Leu Gln Lys  Asp Met Val Val Met  Leu Leu Ser 
    4010                 4015                 4020             


Leu Leu  Glu Gly Asn Val Val  Asn Gly Met Ile Ala  Arg Gln Met 
    4025                 4030                 4035             


Val Asp  Met Leu Val Glu Ser  Ser Ser Asn Val Glu  Met Ile Leu 
    4040                 4045                 4050             


Lys Phe  Phe Asp Met Phe Leu  Lys Leu Lys Asp Ile  Val Gly Ser 
    4055                 4060                 4065             


Glu Ala  Phe Gln Asp Tyr Val  Thr Asp Pro Arg Gly  Leu Ile Ser 
    4070                 4075                 4080             


Lys Lys  Asp Phe Gln Lys Ala  Met Asp Ser Gln Lys  Gln Phe Ser 
    4085                 4090                 4095             


Gly Pro  Glu Ile Gln Phe Leu  Leu Ser Cys Ser Glu  Ala Asp Glu 
    4100                 4105                 4110             


Asn Glu  Met Ile Asn Cys Glu  Glu Phe Ala Asn Arg  Phe Gln Glu 
    4115                 4120                 4125             


Pro Ala  Arg Asp Ile Gly Phe  Asn Val Ala Val Leu  Leu Thr Asn 
    4130                 4135                 4140             


Leu Ser  Glu His Val Pro His  Asp Pro Arg Leu His  Asn Phe Leu 
    4145                 4150                 4155             


Glu Leu  Ala Glu Ser Ile Leu  Glu Tyr Phe Arg Pro  Tyr Leu Gly 
    4160                 4165                 4170             


Arg Ile  Glu Ile Met Gly Ala  Ser Arg Arg Ile Glu  Arg Ile Tyr 
    4175                 4180                 4185             


Phe Glu  Ile Ser Glu Thr Asn  Arg Ala Gln Trp Glu  Met Pro Gln 
    4190                 4195                 4200             


Val Lys  Glu Ser Lys Arg Gln  Phe Ile Phe Asp Val  Val Asn Glu 
    4205                 4210                 4215             


Gly Gly  Glu Ala Glu Lys Met  Glu Leu Phe Val Ser  Phe Cys Glu 
    4220                 4225                 4230             


Asp Thr  Ile Phe Glu Met Gln  Ile Ala Ala Gln Ile  Ser Glu Pro 
    4235                 4240                 4245             


Glu Gly  Glu Pro Glu Thr Asp  Glu Asp Glu Gly Ala  Gly Ala Ala 
    4250                 4255                 4260             


Glu Ala  Gly Ala Glu Gly Ala  Glu Glu Gly Ala Ala  Gly Leu Glu 
    4265                 4270                 4275             


Gly Thr  Ala Ala Thr Ala Ala  Ala Gly Ala Thr Ala  Arg Val Val 
    4280                 4285                 4290             


Ala Ala  Ala Gly Arg Ala Leu  Arg Gly Leu Ser Tyr  Arg Ser Leu 
    4295                 4300                 4305             


Arg Arg  Arg Val Arg Arg Leu  Arg Arg Leu Thr Ala  Arg Glu Ala 
    4310                 4315                 4320             


Ala Thr  Ala Val Ala Ala Leu  Leu Trp Ala Ala Val  Thr Arg Ala 
    4325                 4330                 4335             


Gly Ala  Ala Gly Ala Gly Ala  Ala Ala Gly Ala Leu  Gly Leu Leu 
    4340                 4345                 4350             


Trp Gly  Ser Leu Phe Gly Gly  Gly Leu Val Glu Gly  Ala Lys Lys 
    4355                 4360                 4365             


Val Thr  Val Thr Glu Leu Leu  Ala Gly Met Pro Asp  Pro Thr Ser 
    4370                 4375                 4380             


Asp Glu  Val His Gly Glu Gln  Pro Ala Gly Pro Gly  Gly Asp Ala 
    4385                 4390                 4395             


Asp Gly  Glu Gly Ala Ser Glu  Gly Ala Gly Asp Ala  Ala Glu Gly 
    4400                 4405                 4410             


Ala Gly  Asp Glu Glu Glu Ala  Val His Glu Ala Gly  Pro Gly Gly 
    4415                 4420                 4425             


Ala Asp  Gly Ala Val Ala Val  Thr Asp Gly Gly Pro  Phe Arg Pro 
    4430                 4435                 4440             


Glu Gly  Ala Gly Gly Leu Gly  Asp Met Gly Asp Thr  Thr Pro Ala 
    4445                 4450                 4455             


Glu Pro  Pro Thr Pro Glu Gly  Ser Pro Ile Leu Lys  Arg Lys Leu 
    4460                 4465                 4470             


Gly Val  Asp Gly Val Glu Glu  Glu Leu Pro Pro Glu  Pro Glu Pro 
    4475                 4480                 4485             


Glu Pro  Glu Pro Glu Leu Glu  Pro Glu Lys Ala Asp  Ala Glu Asn 
    4490                 4495                 4500             


Gly Glu  Lys Glu Glu Val Pro  Glu Pro Thr Pro Glu  Pro Pro Lys 
    4505                 4510                 4515             


Lys Gln  Ala Pro Pro Ser Pro  Pro Pro Lys Lys Glu  Glu Ala Gly 
    4520                 4525                 4530             


Gly Glu  Phe Trp Gly Glu Leu  Glu Val Gln Arg Val  Lys Phe Leu 
    4535                 4540                 4545             


Asn Tyr  Leu Ser Arg Asn Phe  Tyr Thr Leu Arg Phe  Leu Ala Leu 
    4550                 4555                 4560             


Phe Leu  Ala Phe Ala Ile Asn  Phe Ile Leu Leu Phe  Tyr Lys Val 
    4565                 4570                 4575             


Ser Asp  Ser Pro Pro Gly Glu  Asp Asp Met Glu Gly  Ser Ala Ala 
    4580                 4585                 4590             


Gly Asp  Val Ser Gly Ala Gly  Ser Gly Gly Ser Ser  Gly Trp Gly 
    4595                 4600                 4605             


Leu Gly  Ala Gly Glu Glu Ala  Glu Gly Asp Glu Asp  Glu Asn Met 
    4610                 4615                 4620             


Val Tyr  Tyr Phe Leu Glu Glu  Ser Thr Gly Tyr Met  Glu Pro Ala 
    4625                 4630                 4635             


Leu Arg  Cys Leu Ser Leu Leu  His Thr Leu Val Ala  Phe Leu Cys 
    4640                 4645                 4650             


Ile Ile  Gly Tyr Asn Cys Leu  Lys Val Pro Leu Val  Ile Phe Lys 
    4655                 4660                 4665             


Arg Glu  Lys Glu Leu Ala Arg  Lys Leu Glu Phe Asp  Gly Leu Tyr 
    4670                 4675                 4680             


Ile Thr  Glu Gln Pro Glu Asp  Asp Asp Val Lys Gly  Gln Trp Asp 
    4685                 4690                 4695             


Arg Leu  Val Leu Asn Thr Pro  Ser Phe Pro Ser Asn  Tyr Trp Asp 
    4700                 4705                 4710             


Lys Phe  Val Lys Arg Lys Val  Leu Asp Lys His Gly  Asp Ile Tyr 
    4715                 4720                 4725             


Gly Arg  Glu Arg Ile Ala Glu  Leu Leu Gly Met Asp  Leu Ala Thr 
    4730                 4735                 4740             


Leu Glu  Ile Thr Ala His Asn  Glu Arg Lys Pro Asn  Pro Pro Pro 
    4745                 4750                 4755             


Gly Leu  Leu Thr Trp Leu Met  Ser Ile Asp Val Lys  Tyr Gln Ile 
    4760                 4765                 4770             


Trp Lys  Phe Gly Val Ile Phe  Thr Asp Asn Ser Phe  Leu Tyr Leu 
    4775                 4780                 4785             


Gly Trp  Tyr Met Val Met Ser  Leu Leu Gly His Tyr  Asn Asn Phe 
    4790                 4795                 4800             


Phe Phe  Ala Ala His Leu Leu  Asp Ile Ala Met Gly  Val Lys Thr 
    4805                 4810                 4815             


Leu Arg  Thr Ile Leu Ser Ser  Val Thr His Asn Gly  Lys Gln Leu 
    4820                 4825                 4830             


Val Met  Thr Val Gly Leu Leu  Ala Val Val Val Tyr  Leu Tyr Thr 
    4835                 4840                 4845             


Val Val  Ala Phe Asn Phe Phe  Arg Lys Phe Tyr Asn  Lys Ser Glu 
    4850                 4855                 4860             


Asp Glu  Asp Glu Pro Asp Met  Lys Cys Asp Asp Met  Met Thr Cys 
    4865                 4870                 4875             


Tyr Leu  Phe His Met Tyr Val  Gly Val Arg Ala Gly  Gly Gly Ile 
    4880                 4885                 4890             


Gly Asp  Glu Ile Glu Asp Pro  Ala Gly Asp Glu Tyr  Glu Leu Tyr 
    4895                 4900                 4905             


Arg Val  Val Phe Asp Ile Thr  Phe Phe Phe Phe Val  Ile Val Ile 
    4910                 4915                 4920             


Leu Leu  Ala Ile Ile Gln Gly  Leu Ile Ile Asp Ala  Phe Gly Glu 
    4925                 4930                 4935             


Leu Arg  Asp Gln Gln Glu Gln  Val Lys Glu Asp Met  Glu Thr Lys 
    4940                 4945                 4950             


Cys Phe  Ile Cys Gly Ile Gly  Ser Asp Tyr Phe Asp  Thr Thr Pro 
    4955                 4960                 4965             


His Gly  Phe Glu Thr His Thr  Leu Glu Glu His Asn  Leu Ala Asn 
    4970                 4975                 4980             


Tyr Met  Phe Phe Leu Met Tyr  Leu Ile Asn Lys Asp  Glu Thr Glu 
    4985                 4990                 4995             


His Thr  Gly Gln Glu Ser Tyr  Val Trp Lys Met Tyr  Gln Glu Arg 
    5000                 5005                 5010             


Cys Trp  Asp Phe Phe Pro Ala  Gly Asp Cys Phe Arg  Lys Gln Tyr 
    5015                 5020                 5025             


Glu Asp  Gln Leu Ser 
    5030             


<210>  918
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  918

Met Ala Arg Ala Ala Ala Leu Leu Pro Ser Arg Ser Pro Pro Thr Pro 
1               5                   10                  15      


Leu Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Glu Thr Gly Ala Gln 
            20                  25                  30          


Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly Gly 
        35                  40                  45              


Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu Tyr 
    50                  55                  60                  


Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His Gln 
65                  70                  75                  80  


Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser Pro 
                85                  90                  95      


Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser Thr 
            100                 105                 110         


Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu His 
        115                 120                 125             


Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala Thr 
    130                 135                 140                 


Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile Ala 
145                 150                 155                 160 


Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln Asp 
                165                 170                 175     


Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro Ala 
            180                 185                 190         


Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr Gln 
        195                 200                 205             


Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe Thr 
    210                 215                 220                 


Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys Val 
225                 230                 235                 240 


Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu Ser 
                245                 250                 255     


Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn Trp 
            260                 265                 270         


Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser Asn 
        275                 280                 285             


Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe Pro 
    290                 295                 300                 


Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val Asp 
305                 310                 315                 320 


Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val Gly 
                325                 330                 335     


Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn Thr 
            340                 345                 350         


Ala Gly Ala Gly Ala Thr Gly Gly Ile Ile Gly Gly Ile Ile Ala Ala 
        355                 360                 365             


Ile Ile Ala Thr Ala Val Ala Ala Thr Gly Ile Leu Ile Cys Arg Gln 
    370                 375                 380                 


Gln Arg Lys Glu Gln Thr Leu Gln Gly Ala Glu Glu Asp Glu Asp Leu 
385                 390                 395                 400 


Glu Gly Pro Pro Ser Tyr Lys Pro Pro Thr Pro Lys Ala Lys Leu Glu 
                405                 410                 415     


Ala Gln Glu Met Pro Ser Gln Leu Phe Thr Leu Gly Ala Ser Glu His 
            420                 425                 430         


Ser Pro Leu Lys Thr Pro Tyr Phe Asp Ala Gly Ala Ser Cys Thr Glu 
        435                 440                 445             


Gln Glu Met Pro Arg Tyr His Glu Leu Pro Thr Leu Glu Glu Arg Ser 
    450                 455                 460                 


Gly Pro Leu His Pro Gly Ala Thr Ser Leu Gly Ser Pro Ile Pro Val 
465                 470                 475                 480 


Pro Pro Gly Pro Pro Ala Val Glu Asp Val Ser Leu Asp Leu Glu Asp 
                485                 490                 495     


Glu Glu Gly Glu Glu Glu Glu Glu Tyr Leu Asp Lys Ile Asn Pro Ile 
            500                 505                 510         


Tyr Asp Ala Leu Ser Tyr Ser Ser Pro Ser Asp Ser Tyr Gln Gly Lys 
        515                 520                 525             


Gly Phe Val Met Ser Arg Ala Met Tyr Val 
    530                 535             


<210>  919
<211>  1212
<212>  PRT
<213>  Homo sapiens

<400>  919

Met Glu Pro Arg Pro Thr Ala Pro Ser Ser Gly Ala Pro Gly Leu Ala 
1               5                   10                  15      


Gly Val Gly Glu Thr Pro Ser Ala Ala Ala Leu Ala Ala Ala Arg Val 
            20                  25                  30          


Glu Leu Pro Gly Thr Ala Val Pro Ser Val Pro Glu Asp Ala Ala Pro 
        35                  40                  45              


Ala Ser Arg Asp Gly Gly Gly Val Arg Asp Glu Gly Pro Ala Ala Ala 
    50                  55                  60                  


Gly Asp Gly Leu Gly Arg Pro Leu Gly Pro Thr Pro Ser Gln Ser Arg 
65                  70                  75                  80  


Phe Gln Val Asp Leu Val Ser Glu Asn Ala Gly Arg Ala Ala Ala Ala 
                85                  90                  95      


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Ala Gly Ala Gly 
            100                 105                 110         


Ala Lys Gln Thr Pro Ala Asp Gly Glu Ala Ser Gly Glu Ser Glu Pro 
        115                 120                 125             


Ala Lys Gly Ser Glu Glu Ala Lys Gly Arg Phe Arg Val Asn Phe Val 
    130                 135                 140                 


Asp Pro Ala Ala Ser Ser Ser Ala Glu Asp Ser Leu Ser Asp Ala Ala 
145                 150                 155                 160 


Gly Val Gly Val Asp Gly Pro Asn Val Ser Phe Gln Asn Gly Gly Asp 
                165                 170                 175     


Thr Val Leu Ser Glu Gly Ser Ser Leu His Ser Gly Gly Gly Gly Gly 
            180                 185                 190         


Ser Gly His His Gln His Tyr Tyr Tyr Asp Thr His Thr Asn Thr Tyr 
        195                 200                 205             


Tyr Leu Arg Thr Phe Gly His Asn Thr Met Asp Ala Val Pro Arg Ile 
    210                 215                 220                 


Asp His Tyr Arg His Thr Ala Ala Gln Leu Gly Glu Lys Leu Leu Arg 
225                 230                 235                 240 


Pro Ser Leu Ala Glu Leu His Asp Glu Leu Glu Lys Glu Pro Phe Glu 
                245                 250                 255     


Asp Gly Phe Ala Asn Gly Glu Glu Ser Thr Pro Thr Arg Asp Ala Val 
            260                 265                 270         


Val Thr Tyr Thr Ala Glu Ser Lys Gly Val Val Lys Phe Gly Trp Ile 
        275                 280                 285             


Lys Gly Val Leu Val Arg Cys Met Leu Asn Ile Trp Gly Val Met Leu 
    290                 295                 300                 


Phe Ile Arg Leu Ser Trp Ile Val Gly Gln Ala Gly Ile Gly Leu Ser 
305                 310                 315                 320 


Val Leu Val Ile Met Met Ala Thr Val Val Thr Thr Ile Thr Gly Leu 
                325                 330                 335     


Ser Thr Ser Ala Ile Ala Thr Asn Gly Phe Val Arg Gly Gly Gly Ala 
            340                 345                 350         


Tyr Tyr Leu Ile Ser Arg Ser Leu Gly Pro Glu Phe Gly Gly Ala Ile 
        355                 360                 365             


Gly Leu Ile Phe Ala Phe Ala Asn Ala Val Ala Val Ala Met Tyr Val 
    370                 375                 380                 


Val Gly Phe Ala Glu Thr Val Val Glu Leu Leu Lys Glu His Ser Ile 
385                 390                 395                 400 


Leu Met Ile Asp Glu Ile Asn Asp Ile Arg Ile Ile Gly Ala Ile Thr 
                405                 410                 415     


Val Val Ile Leu Leu Gly Ile Ser Val Ala Gly Met Glu Trp Glu Ala 
            420                 425                 430         


Lys Ala Gln Ile Val Leu Leu Val Ile Leu Leu Leu Ala Ile Gly Asp 
        435                 440                 445             


Phe Val Ile Gly Thr Phe Ile Pro Leu Glu Ser Lys Lys Pro Lys Gly 
    450                 455                 460                 


Phe Phe Gly Tyr Lys Ser Glu Ile Phe Asn Glu Asn Phe Gly Pro Asp 
465                 470                 475                 480 


Phe Arg Glu Glu Glu Thr Phe Phe Ser Val Phe Ala Ile Phe Phe Pro 
                485                 490                 495     


Ala Ala Thr Gly Ile Leu Ala Gly Ala Asn Ile Ser Gly Asp Leu Ala 
            500                 505                 510         


Asp Pro Gln Ser Ala Ile Pro Lys Gly Thr Leu Leu Ala Ile Leu Ile 
        515                 520                 525             


Thr Thr Leu Val Tyr Val Gly Ile Ala Val Ser Val Gly Ser Cys Val 
    530                 535                 540                 


Val Arg Asp Ala Thr Gly Asn Val Asn Asp Thr Ile Val Thr Glu Leu 
545                 550                 555                 560 


Thr Asn Cys Thr Ser Ala Ala Cys Lys Leu Asn Phe Asp Phe Ser Ser 
                565                 570                 575     


Cys Glu Ser Ser Pro Cys Ser Tyr Gly Leu Met Asn Asn Phe Gln Val 
            580                 585                 590         


Met Ser Met Val Ser Gly Phe Thr Pro Leu Ile Ser Ala Gly Ile Phe 
        595                 600                 605             


Ser Ala Thr Leu Ser Ser Ala Leu Ala Ser Leu Val Ser Ala Pro Lys 
    610                 615                 620                 


Ile Phe Gln Ala Leu Cys Lys Asp Asn Ile Tyr Pro Ala Phe Gln Met 
625                 630                 635                 640 


Phe Ala Lys Gly Tyr Gly Lys Asn Asn Glu Pro Leu Arg Gly Tyr Ile 
                645                 650                 655     


Leu Thr Phe Leu Ile Ala Leu Gly Phe Ile Leu Ile Ala Glu Leu Asn 
            660                 665                 670         


Val Ile Ala Pro Ile Ile Ser Asn Phe Phe Leu Ala Ser Tyr Ala Leu 
        675                 680                 685             


Ile Asn Phe Ser Val Phe His Ala Ser Leu Ala Lys Ser Pro Gly Trp 
    690                 695                 700                 


Arg Pro Ala Phe Lys Tyr Tyr Asn Met Trp Ile Ser Leu Leu Gly Ala 
705                 710                 715                 720 


Ile Leu Cys Cys Ile Val Met Phe Val Ile Asn Trp Trp Ala Ala Leu 
                725                 730                 735     


Leu Thr Tyr Val Ile Val Leu Gly Leu Tyr Ile Tyr Val Thr Tyr Lys 
            740                 745                 750         


Lys Pro Asp Val Asn Trp Gly Ser Ser Thr Gln Ala Leu Thr Tyr Leu 
        755                 760                 765             


Asn Ala Leu Gln His Ser Ile Arg Leu Ser Gly Val Glu Asp His Val 
    770                 775                 780                 


Lys Asn Phe Arg Pro Gln Cys Leu Val Met Thr Gly Ala Pro Asn Ser 
785                 790                 795                 800 


Arg Pro Ala Leu Leu His Leu Val His Asp Phe Thr Lys Asn Val Gly 
                805                 810                 815     


Leu Met Ile Cys Gly His Val His Met Gly Pro Arg Arg Gln Ala Met 
            820                 825                 830         


Lys Glu Met Ser Ile Asp Gln Ala Lys Tyr Gln Arg Trp Leu Ile Lys 
        835                 840                 845             


Asn Lys Met Lys Ala Phe Tyr Ala Pro Val His Ala Asp Asp Leu Arg 
    850                 855                 860                 


Glu Gly Ala Gln Tyr Leu Met Gln Ala Ala Gly Leu Gly Arg Met Lys 
865                 870                 875                 880 


Pro Asn Thr Leu Val Leu Gly Phe Lys Lys Asp Trp Leu Gln Ala Asp 
                885                 890                 895     


Met Arg Asp Val Asp Met Tyr Ile Asn Leu Phe His Asp Ala Phe Asp 
            900                 905                 910         


Ile Gln Tyr Gly Val Val Val Ile Arg Leu Lys Glu Gly Leu Asp Ile 
        915                 920                 925             


Ser His Leu Gln Gly Gln Glu Glu Leu Leu Ser Ser Gln Glu Lys Ser 
    930                 935                 940                 


Pro Gly Thr Lys Asp Val Val Val Ser Val Glu Tyr Ser Lys Lys Ser 
945                 950                 955                 960 


Asp Leu Asp Thr Ser Lys Pro Leu Ser Glu Lys Pro Ile Thr His Lys 
                965                 970                 975     


Val Glu Glu Glu Asp Gly Lys Thr Ala Thr Gln Pro Leu Leu Lys Lys 
            980                 985                 990         


Glu Ser Lys Gly Pro Ile Val Pro  Leu Asn Val Ala Asp  Gln Lys Leu 
        995                 1000                 1005             


Leu Glu  Ala Ser Thr Gln Phe  Gln Lys Lys Gln Gly  Lys Asn Thr 
    1010                 1015                 1020             


Ile Asp  Val Trp Trp Leu Phe  Asp Asp Gly Gly Leu  Thr Leu Leu 
    1025                 1030                 1035             


Ile Pro  Tyr Leu Leu Thr Thr  Lys Lys Lys Trp Lys  Asp Cys Lys 
    1040                 1045                 1050             


Ile Arg  Val Phe Ile Gly Gly  Lys Ile Asn Arg Ile  Asp His Asp 
    1055                 1060                 1065             


Arg Arg  Ala Met Ala Thr Leu  Leu Ser Lys Phe Arg  Ile Asp Phe 
    1070                 1075                 1080             


Ser Asp  Ile Met Val Leu Gly  Asp Ile Asn Thr Lys  Pro Lys Lys 
    1085                 1090                 1095             


Glu Asn  Ile Ile Ala Phe Glu  Glu Ile Ile Glu Pro  Tyr Arg Leu 
    1100                 1105                 1110             


His Glu  Asp Asp Lys Glu Gln  Asp Ile Ala Asp Lys  Met Lys Glu 
    1115                 1120                 1125             


Asp Glu  Pro Trp Arg Ile Thr  Asp Asn Glu Leu Glu  Leu Tyr Lys 
    1130                 1135                 1140             


Thr Lys  Thr Tyr Arg Gln Ile  Arg Leu Asn Glu Leu  Leu Lys Glu 
    1145                 1150                 1155             


His Ser  Ser Thr Ala Asn Ile  Ile Val Met Ser Leu  Pro Val Ala 
    1160                 1165                 1170             


Arg Lys  Gly Ala Val Ser Ser  Ala Leu Tyr Met Ala  Trp Leu Glu 
    1175                 1180                 1185             


Ala Leu  Ser Lys Asp Leu Pro  Pro Ile Leu Leu Val  Arg Gly Asn 
    1190                 1195                 1200             


His Gln  Ser Val Leu Thr Phe  Tyr Ser 
    1205                 1210         


<210>  920
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  920

Met Ala Arg Ala Ala Gly Ala Arg Gly Pro Ala Gly Trp Cys Arg Arg 
1               5                   10                  15      


Arg Gly Arg Cys Gly Arg Gly Thr Leu Leu Ala Phe Ala Ala Trp Thr 
            20                  25                  30          


Ala Gly Trp Val Leu Ala Ala Ala Leu Leu Leu Arg Ala His Pro Gly 
        35                  40                  45              


Val Leu Ser Glu Arg Cys Thr Asp Glu Lys Ser Arg Arg Ile Leu Ala 
    50                  55                  60                  


Ala Leu Cys Gln Asp Tyr Gln Gly Gly Thr Leu Ala Gly Asp Leu Cys 
65                  70                  75                  80  


Glu Asp Leu Cys Val Ala Gly Glu Leu Leu Phe Gln Arg Cys Leu His 
                85                  90                  95      


Tyr Asn Arg Gly Lys Lys Val Leu Gln Ala Asp Trp Arg Gly Arg Pro 
            100                 105                 110         


Val Val Leu Lys Ser Lys Glu Glu Ala Phe Ser Ser Phe Pro Pro Leu 
        115                 120                 125             


Ser Leu Leu Glu Glu Glu Ala Gly Glu Gly Gly Gln Asp Met Pro Glu 
    130                 135                 140                 


Ala Glu Leu Leu Leu Met Val Ala Gly Glu Val Lys Ser Ala Leu Gly 
145                 150                 155                 160 


Leu Glu Leu Ser Asn Ser Ser Leu Gly Pro Trp Trp Pro Gly Arg Arg 
                165                 170                 175     


Gly Pro Arg Trp Arg Gly Gln Leu Ala Ser Leu Trp Ala Leu Leu Gln 
            180                 185                 190         


Gln Glu Glu Tyr Val Tyr Phe Ser Leu Leu Gln Asp Leu Ser Pro His 
        195                 200                 205             


Val Leu Pro Val Leu Gly Ser Cys Gly His Phe Tyr Ala Val Glu Phe 
    210                 215                 220                 


Leu Ala Ala Gly Ser Pro His His Arg Ala Leu Phe Pro Leu Asp Arg 
225                 230                 235                 240 


Ala Pro Gly Ala Pro Gly Gly Gly Gln Ala Lys Ala Ile Ser Asp Ile 
                245                 250                 255     


Ala Leu Ser Phe Leu Asp Met Val Asn His Phe Asp Ser Asp Phe Ser 
            260                 265                 270         


His Arg Leu His Leu Cys Asp Ile Lys Pro Glu Asn Phe Ala Ile Arg 
        275                 280                 285             


Ser Asp Phe Thr Val Val Ala Ile Asp Val Asp Met Ala Phe Phe Glu 
    290                 295                 300                 


Pro Lys Met Arg Glu Ile Leu Glu Gln Asn Cys Thr Gly Asp Glu Asp 
305                 310                 315                 320 


Cys Asn Phe Phe Asp Cys Phe Ser Arg Cys Asp Leu Arg Val Asn Lys 
                325                 330                 335     


Cys Gly Ala Gln Arg Val Asn Asn Asn Leu Gln Val Ile Cys Asp Lys 
            340                 345                 350         


Ile Phe Arg His Trp Phe Ser Ala Pro Leu Lys Ser Ser Ala Val Ser 
        355                 360                 365             


Phe Gln Leu Gln Leu Gln Leu Gln Glu Ala Val Gln Glu Cys Ala Asp 
    370                 375                 380                 


Pro Gly Val Pro Ser Gly Asn Thr Arg Arg Ala Ala Ser Ser Val Phe 
385                 390                 395                 400 


Trp Lys Leu Arg Gln Leu Leu Gln Ala Thr Leu Arg Glu Leu Gln Glu 
                405                 410                 415     


Ala Glu Lys 
            


<210>  921
<211>  408
<212>  PRT
<213>  Homo sapiens

<400>  921

Met Arg Thr Asp Ser Gly Ala Arg Leu Glu Glu Gly His Leu Arg Pro 
1               5                   10                  15      


Pro Arg Ala Leu Pro Pro Val Pro Ser Gln Asp Asp Ile Pro Leu Ser 
            20                  25                  30          


Arg Pro Lys Lys Lys Lys Pro Arg Thr Lys Asn Thr Pro Ala Ser Ala 
        35                  40                  45              


Ser Leu Glu Gly Leu Ala Gln Thr Ala Gly Arg Arg Pro Ser Glu Gly 
    50                  55                  60                  


Asn Glu Pro Ser Thr Lys Glu Leu Lys Glu His Pro Glu Ala Pro Val 
65                  70                  75                  80  


Gln Arg Arg Gln Lys Lys Thr Arg Leu Pro Leu Glu Leu Glu Thr Ser 
                85                  90                  95      


Ser Thr Gln Lys Lys Ser Ser Ser Ser Ser Leu Leu Arg Asn Glu Asn 
            100                 105                 110         


Gly Ile Asp Ala Glu Pro Ala Glu Glu Ala Val Ile Gln Lys Pro Arg 
        115                 120                 125             


Arg Lys Thr Lys Lys Thr Gln Pro Ala Glu Leu Gln Tyr Ala Asn Glu 
    130                 135                 140                 


Leu Gly Val Glu Asp Glu Asp Ile Ile Thr Asp Glu Gln Thr Thr Val 
145                 150                 155                 160 


Glu Gln Gln Ser Val Phe Thr Ala Pro Thr Gly Ile Ser Gln Pro Val 
                165                 170                 175     


Gly Lys Val Phe Val Glu Lys Ser Arg Arg Phe Gln Ala Ala Asp Arg 
            180                 185                 190         


Ser Glu Leu Ile Lys Thr Thr Glu Asn Ile Asp Val Ser Met Asp Val 
        195                 200                 205             


Lys Pro Ser Trp Thr Thr Arg Asp Val Ala Leu Thr Val His Arg Ala 
    210                 215                 220                 


Phe Arg Met Ile Gly Leu Phe Ser His Gly Phe Leu Ala Gly Cys Ala 
225                 230                 235                 240 


Val Trp Asn Ile Val Val Ile Tyr Val Leu Ala Gly Asp Gln Leu Ser 
                245                 250                 255     


Asn Leu Ser Asn Leu Leu Gln Gln Tyr Lys Thr Leu Ala Tyr Pro Phe 
            260                 265                 270         


Gln Ser Leu Leu Tyr Leu Leu Leu Ala Leu Ser Thr Ile Ser Ala Phe 
        275                 280                 285             


Asp Arg Ile Asp Phe Ala Lys Ile Ser Val Ala Ile Arg Asn Phe Leu 
    290                 295                 300                 


Ala Leu Asp Pro Thr Ala Leu Ala Ser Phe Leu Tyr Phe Thr Ala Leu 
305                 310                 315                 320 


Ile Leu Ser Leu Ser Gln Gln Met Thr Ser Asp Arg Ile His Leu Tyr 
                325                 330                 335     


Thr Pro Ser Ser Val Asn Gly Ser Leu Trp Glu Ala Gly Ile Glu Glu 
            340                 345                 350         


Gln Ile Leu Gln Pro Trp Ile Val Val Asn Leu Val Val Ala Leu Leu 
        355                 360                 365             


Val Gly Leu Ser Trp Leu Phe Leu Ser Tyr Arg Pro Gly Met Asp Leu 
    370                 375                 380                 


Ser Glu Glu Leu Met Phe Ser Ser Glu Val Glu Glu Tyr Pro Asp Lys 
385                 390                 395                 400 


Glu Lys Glu Ile Lys Ala Ser Ser 
                405             


<210>  922
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  922

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Ile Pro Ala Pro Thr Thr Thr Lys Ser Cys Arg 
    50                  55                  60                  


Glu Thr Phe Leu Lys Cys Phe Cys Arg Phe Ile Asn Lys Gly Val Phe 
65                  70                  75                  80  


Trp Ala Ser Pro Ile Leu Ser Ser Val Ser Asp Val Pro Phe Pro Phe 
                85                  90                  95      


Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu 
            100                 105                 110         


Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala 
        115                 120                 125             


Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile 
    130                 135                 140                 


Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr 
145                 150                 155                 160 


His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro 
                165                 170                 175     


Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr 
            180                 185                 190         


Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
        195                 200             


<210>  923
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  923

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp 
    50                  55                  60                  


Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Ala Val Cys Gln 
65                  70                  75                  80  


Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp 
                85                  90                  95      


Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg 
            100                 105                 110         


Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser 
        115                 120                 125             


Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala 
    130                 135                 140                 


Ala Thr Ser Ala Asn Leu 
145                 150 


<210>  924
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  924

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 
    50                  55                  60                  


Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 
65                  70                  75                  80  


Asp Ile Ser Glu Met Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly 
                85                  90                  95      


Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu 
            100                 105                 110         


Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr 
        115                 120                 125             


Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser 
    130                 135                 140                 


Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
145                 150                 155                 


<210>  925
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  925

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Ile Pro Ala Pro Thr Thr Thr Lys Ser Cys Arg 
    50                  55                  60                  


Glu Thr Phe Leu Lys Cys Phe Cys Arg Phe Ile Asn Lys Gly Val Phe 
65                  70                  75                  80  


Trp Ala Ser Pro Ile Leu Ser Ser Val Trp Gly Trp Gly Ala Arg Leu 
                85                  90                  95      


Gly His Arg Ala Ala Gly Ala Gly Leu Cys Ser Gly Cys Ala Gly His 
            100                 105                 110         


Cys Leu Ser His Cys Leu Gly Cys Leu Ser Val Pro Pro Lys Glu Leu 
        115                 120                 125             


Arg Ala Ala Gly His Leu Ser Ser Pro Gly Tyr Leu Pro Ser Tyr Glu 
    130                 135                 140                 


Arg Val Pro His Leu Pro His Pro Trp Ala Leu Cys Ala Pro 
145                 150                 155             


<210>  926
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  926

Met Ala Thr Ala Thr Gly Val Ala Glu Glu Arg Leu Leu Ala Ala Leu 
1               5                   10                  15      


Ala Tyr Leu Gln Cys Ala Val Gly Cys Ala Val Phe Ala Arg Asn Arg 
            20                  25                  30          


Gln Thr Asn Ser Val Tyr Gly Arg His Ala Leu Pro Ser His Arg Leu 
        35                  40                  45              


Arg Val Pro Ala Arg Ala Ala Trp Val Val Gln Glu Leu Pro Ser Leu 
    50                  55                  60                  


Ala Leu Pro Leu Tyr Gln Tyr Ala Ser Glu Ser Ala Pro Arg Leu Arg 
65                  70                  75                  80  


Ser Ala Pro Asn Cys Ile Leu Leu Ala Met Phe Leu Val His Tyr Gly 
                85                  90                  95      


His Arg Cys Leu Ile Tyr Pro Phe Leu Met Arg Gly Gly Lys Pro Met 
            100                 105                 110         


Pro Leu Leu Ala Cys Thr Met Ala Ile Met Phe Cys Thr Cys Asn Gly 
        115                 120                 125             


Tyr Leu Gln Ser Arg Tyr Leu Ser His Cys Ala Val Tyr Ala Asp Asp 
    130                 135                 140                 


Trp Val Thr Asp Pro Arg Phe Leu Ile Gly Phe Gly Leu Trp Leu Thr 
145                 150                 155                 160 


Gly Met Leu Ile Asn Ile His Ser Asp His Ile Leu Arg Asn Leu Arg 
                165                 170                 175     


Lys Pro Gly Asp Thr Gly Tyr Lys Ile Pro Arg Gly Gly Leu Phe Glu 
            180                 185                 190         


Tyr Val Thr Ala Ala Asn Tyr Phe Gly Glu Ile Met Glu Trp Cys Gly 
        195                 200                 205             


Tyr Ala Leu Ala Ser Trp Ser Val Gln Gly Ala Ala Phe Ala Phe Phe 
    210                 215                 220                 


Thr Phe Cys Phe Leu Ser Gly Arg Ala Lys Glu His His Glu Trp Tyr 
225                 230                 235                 240 


Leu Arg Lys Phe Glu Glu Tyr Pro Lys Phe Arg Lys Ile Ile Ile Pro 
                245                 250                 255     


Phe Leu Phe 
            


<210>  927
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  927

Met Phe Pro Asn Gly Thr Ala Ser Ser Pro Ser Ser Ser Pro Ser Pro 
1               5                   10                  15      


Ser Pro Gly Ser Cys Gly Glu Gly Gly Gly Ser Arg Gly Pro Gly Ala 
            20                  25                  30          


Gly Ala Ala Asp Gly Met Glu Glu Pro Gly Arg Asn Ala Ser Gln Asn 
        35                  40                  45              


Gly Thr Leu Ser Glu Gly Gln Gly Ser Ala Ile Leu Ile Ser Phe Ile 
    50                  55                  60                  


Tyr Ser Val Val Cys Leu Val Gly Leu Cys Gly Asn Ser Met Val Ile 
65                  70                  75                  80  


Tyr Val Ile Leu Arg Tyr Ala Lys Met Lys Thr Ala Thr Asn Ile Tyr 
                85                  90                  95      


Ile Leu Asn Leu Ala Ile Ala Asp Glu Leu Leu Met Leu Ser Val Pro 
            100                 105                 110         


Phe Leu Val Thr Ser Thr Leu Leu Arg His Trp Pro Phe Gly Ala Leu 
        115                 120                 125             


Leu Cys Arg Leu Val Leu Ser Val Asp Ala Val Asn Met Phe Thr Ser 
    130                 135                 140                 


Ile Tyr Cys Leu Thr Val Leu Ser Val Asp Arg Tyr Val Ala Val Val 
145                 150                 155                 160 


His Pro Ile Lys Ala Ala Arg Tyr Arg Arg Pro Thr Val Ala Lys Val 
                165                 170                 175     


Val Asn Leu Gly Val Trp Val Leu Ser Leu Leu Val Ile Leu Pro Ile 
            180                 185                 190         


Val Val Phe Ser Arg Thr Ala Ala Asn Ser Asp Gly Thr Val Ala Cys 
        195                 200                 205             


Asn Met Leu Met Pro Glu Pro Ala Gln Arg Trp Leu Val Gly Phe Val 
    210                 215                 220                 


Leu Tyr Thr Phe Leu Met Gly Phe Leu Leu Pro Val Gly Ala Ile Cys 
225                 230                 235                 240 


Leu Cys Tyr Val Leu Ile Ile Ala Lys Met Arg Met Val Ala Leu Lys 
                245                 250                 255     


Ala Gly Trp Gln Gln Arg Lys Arg Ser Glu Arg Lys Ile Thr Leu Met 
            260                 265                 270         


Val Met Met Val Val Met Val Phe Val Ile Cys Trp Met Pro Phe Tyr 
        275                 280                 285             


Val Val Gln Leu Val Asn Val Phe Ala Glu Gln Asp Asp Ala Thr Val 
    290                 295                 300                 


Ser Gln Leu Ser Val Ile Leu Gly Tyr Ala Asn Ser Cys Ala Asn Pro 
305                 310                 315                 320 


Ile Leu Tyr Gly Phe Leu Ser Asp Asn Phe Lys Arg Ser Phe Gln Arg 
                325                 330                 335     


Ile Leu Cys Leu Ser Trp Met Asp Asn Ala Ala Glu Glu Pro Val Asp 
            340                 345                 350         


Tyr Tyr Ala Thr Ala Leu Lys Ser Arg Ala Tyr Ser Val Glu Asp Phe 
        355                 360                 365             


Gln Pro Glu Asn Leu Glu Ser Gly Gly Val Phe Arg Asn Gly Thr Cys 
    370                 375                 380                 


Thr Ser Arg Ile Thr Thr Leu 
385                 390     


<210>  928
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  928

Met Asp Met Ala Asp Glu Pro Leu Asn Gly Ser His Thr Trp Leu Ser 
1               5                   10                  15      


Ile Pro Phe Asp Leu Asn Gly Ser Val Val Ser Thr Asn Thr Ser Asn 
            20                  25                  30          


Gln Thr Glu Pro Tyr Tyr Asp Leu Thr Ser Asn Ala Val Leu Thr Phe 
        35                  40                  45              


Ile Tyr Phe Val Val Cys Ile Ile Gly Leu Cys Gly Asn Thr Leu Val 
    50                  55                  60                  


Ile Tyr Val Ile Leu Arg Tyr Ala Lys Met Lys Thr Ile Thr Asn Ile 
65                  70                  75                  80  


Tyr Ile Leu Asn Leu Ala Ile Ala Asp Glu Leu Phe Met Leu Gly Leu 
                85                  90                  95      


Pro Phe Leu Ala Met Gln Val Ala Leu Val His Trp Pro Phe Gly Lys 
            100                 105                 110         


Ala Ile Cys Arg Val Val Met Thr Val Asp Gly Ile Asn Gln Phe Thr 
        115                 120                 125             


Ser Ile Phe Cys Leu Thr Val Met Ser Ile Asp Arg Tyr Leu Ala Val 
    130                 135                 140                 


Val His Pro Ile Lys Ser Ala Lys Trp Arg Arg Pro Arg Thr Ala Lys 
145                 150                 155                 160 


Met Ile Thr Met Ala Val Trp Gly Val Ser Leu Leu Val Ile Leu Pro 
                165                 170                 175     


Ile Met Ile Tyr Ala Gly Leu Arg Ser Asn Gln Trp Gly Arg Ser Ser 
            180                 185                 190         


Cys Thr Ile Asn Trp Pro Gly Glu Ser Gly Ala Trp Tyr Thr Gly Phe 
        195                 200                 205             


Ile Ile Tyr Thr Phe Ile Leu Gly Phe Leu Val Pro Leu Thr Ile Ile 
    210                 215                 220                 


Cys Leu Cys Tyr Leu Phe Ile Ile Ile Lys Val Lys Ser Ser Gly Ile 
225                 230                 235                 240 


Arg Val Gly Ser Ser Lys Arg Lys Lys Ser Glu Lys Lys Val Thr Arg 
                245                 250                 255     


Met Val Ser Ile Val Val Ala Val Phe Ile Phe Cys Trp Leu Pro Phe 
            260                 265                 270         


Tyr Ile Phe Asn Val Ser Ser Val Ser Met Ala Ile Ser Pro Thr Pro 
        275                 280                 285             


Ala Leu Lys Gly Met Phe Asp Phe Val Val Val Leu Thr Tyr Ala Asn 
    290                 295                 300                 


Ser Cys Ala Asn Pro Ile Leu Tyr Ala Phe Leu Ser Asp Asn Phe Lys 
305                 310                 315                 320 


Lys Ser Phe Gln Asn Val Leu Cys Leu Val Lys Val Ser Gly Thr Asp 
                325                 330                 335     


Asp Gly Glu Arg Ser Asp Ser Lys Gln Asp Lys Ser Arg Leu Asn Glu 
            340                 345                 350         


Thr Thr Glu Thr Gln Arg Thr Leu Leu Asn Gly Asp Leu Gln Thr Ser 
        355                 360                 365             


Ile 
    


<210>  929
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  929

Met Lys Thr Ile Gln Pro Lys Met His Asn Ser Ile Ser Trp Ala Ile 
1               5                   10                  15      


Phe Thr Gly Leu Ala Ala Leu Cys Leu Phe Gln Gly Val Pro Val Arg 
            20                  25                  30          


Ser Gly Asp Ala Thr Phe Pro Lys Ala Met Asp Asn Val Thr Val Arg 
        35                  40                  45              


Gln Gly Glu Ser Ala Thr Leu Arg Cys Thr Ile Asp Asn Arg Val Thr 
    50                  55                  60                  


Arg Val Ala Trp Leu Asn Arg Ser Thr Ile Leu Tyr Ala Gly Asn Asp 
65                  70                  75                  80  


Lys Trp Cys Leu Asp Pro Arg Val Val Leu Leu Ser Asn Thr Gln Thr 
                85                  90                  95      


Gln Tyr Ser Ile Glu Ile Gln Asn Val Asp Val Tyr Asp Glu Gly Pro 
            100                 105                 110         


Tyr Thr Cys Ser Val Gln Thr Asp Asn His Pro Lys Thr Ser Arg Val 
        115                 120                 125             


His Leu Ile Val Gln Val Ser Pro Lys Ile Val Glu Ile Ser Ser Asp 
    130                 135                 140                 


Ile Ser Ile Asn Glu Gly Asn Asn Ile Ser Leu Thr Cys Ile Ala Thr 
145                 150                 155                 160 


Gly Arg Pro Glu Pro Thr Val Thr Trp Arg His Ile Ser Pro Lys Ala 
                165                 170                 175     


Val Gly Phe Val Ser Glu Asp Glu Tyr Leu Glu Ile Gln Gly Ile Thr 
            180                 185                 190         


Arg Glu Gln Ser Gly Asp Tyr Glu Cys Ser Ala Ser Asn Asp Val Ala 
        195                 200                 205             


Ala Pro Val Val Arg Arg Val Lys Val Thr Val Asn Tyr Pro Pro Tyr 
    210                 215                 220                 


Ile Ser Glu Ala Lys Gly Thr Gly Val Pro Val Gly Gln Lys Gly Thr 
225                 230                 235                 240 


Leu Gln Cys Glu Ala Ser Ala Val Pro Ser Ala Glu Phe Gln Trp Tyr 
                245                 250                 255     


Lys Asp Asp Lys Arg Leu Ile Glu Gly Lys Lys Gly Val Lys Val Glu 
            260                 265                 270         


Asn Arg Pro Phe Leu Ser Lys Leu Ile Phe Phe Asn Val Ser Glu His 
        275                 280                 285             


Asp Tyr Gly Asn Tyr Thr Cys Val Ala Ser Asn Lys Leu Gly His Thr 
    290                 295                 300                 


Asn Ala Ser Ile Met Leu Phe Gly Pro Gly Ala Val Ser Glu Val Ser 
305                 310                 315                 320 


Asn Gly Thr Ser Arg Arg Ala Gly Cys Val Trp Leu Leu Pro Leu Leu 
                325                 330                 335     


Val Leu His Leu Leu Leu Lys Phe 
            340                 


<210>  930
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  930

Met Leu Cys Ser Leu Leu Leu Cys Glu Cys Leu Leu Leu Val Ala Gly 
1               5                   10                  15      


Tyr Ala His Asp Asp Asp Trp Ile Asp Pro Thr Asp Met Leu Asn Tyr 
            20                  25                  30          


Asp Ala Ala Ser Gly Thr Met Arg Lys Ser Gln Ala Lys Tyr Gly Ile 
        35                  40                  45              


Ser Gly Glu Lys Asp Val Ser Pro Asp Leu Ser Cys Ala Asp Glu Ile 
    50                  55                  60                  


Ser Glu Cys Tyr His Lys Leu Asp Ser Leu Thr Tyr Lys Ile Asp Glu 
65                  70                  75                  80  


Cys Glu Lys Lys Lys Arg Glu Asp Tyr Glu Ser Gln Ser Asn Pro Val 
                85                  90                  95      


Phe Arg Arg Tyr Leu Asn Lys Ile Leu Ile Glu Ala Gly Lys Leu Gly 
            100                 105                 110         


Leu Pro Asp Glu Asn Lys Gly Asp Met His Tyr Asp Ala Glu Ile Ile 
        115                 120                 125             


Leu Lys Arg Glu Thr Leu Leu Glu Ile Gln Lys Phe Leu Asn Gly Glu 
    130                 135                 140                 


Asp Trp Lys Pro Gly Ala Leu Asp Asp Ala Leu Ser Asp Ile Leu Ile 
145                 150                 155                 160 


Asn Phe Lys Phe His Asp Phe Glu Thr Trp Lys Trp Arg Phe Glu Asp 
                165                 170                 175     


Ser Phe Gly Val Asp Pro Tyr Asn Val Leu Met Val Leu Leu Cys Leu 
            180                 185                 190         


Leu Cys Ile Val Val Leu Val Ala Thr Glu Leu Trp Thr Tyr Val Arg 
        195                 200                 205             


Trp Tyr Thr Gln Leu Arg Arg Val Leu Ile Ile Ser Phe Leu Phe Ser 
    210                 215                 220                 


Leu Gly Trp Asn Trp Met Tyr Leu Tyr Lys Leu Ala Phe Ala Gln His 
225                 230                 235                 240 


Gln Ala Glu Val Ala Lys Met Glu Pro Leu Asn Asn Val Cys Ala Lys 
                245                 250                 255     


Lys Met Asp Trp Thr Gly Ser Ile Trp Glu Trp Phe Arg Ser Ser Trp 
            260                 265                 270         


Thr Tyr Lys Asp Asp Pro Cys Gln Lys Tyr Tyr Glu Leu Leu Leu Val 
        275                 280                 285             


Asn Pro Ile Trp Leu Val Pro Pro Thr Lys Ala Leu Ala Val Thr Phe 
    290                 295                 300                 


Thr Thr Phe Val Thr Glu Pro Leu Lys His Ile Gly Lys Gly Thr Gly 
305                 310                 315                 320 


Glu Phe Ile Lys Ala Leu Met Lys Glu Ile Pro Ala Leu Leu His Leu 
                325                 330                 335     


Pro Val Leu Ile Ile Met Ala Leu Ala Ile Leu Ser Phe Cys Tyr Gly 
            340                 345                 350         


Ala Gly Lys Ser Val His Val Leu Arg His Ile Gly Gly Pro Glu Ser 
        355                 360                 365             


Glu Pro Pro Gln Ala Leu Arg Pro Arg Asp Arg Arg Arg Gln Glu Glu 
    370                 375                 380                 


Ile Asp Tyr Arg Pro Asp Gly Gly Ala Gly Asp Ala Asp Phe His Tyr 
385                 390                 395                 400 


Arg Gly Gln Met Gly Pro Thr Glu Gln Gly Pro Tyr Ala Lys Thr Tyr 
                405                 410                 415     


Glu Gly Arg Arg Glu Ile Leu Arg Glu Arg Asp Val Asp Leu Arg Phe 
            420                 425                 430         


Gln Thr Gly Asn Lys Ser Pro Glu Val Leu Arg Ala Phe Asp Val Pro 
        435                 440                 445             


Asp Ala Glu Ala Arg Glu His Pro Thr Val Val Pro Ser His Lys Ser 
    450                 455                 460                 


Pro Val Leu Asp Thr Lys Pro Lys Glu Thr Gly Gly Ile Leu Gly Glu 
465                 470                 475                 480 


Gly Thr Pro Lys Glu Ser Ser Thr Glu Ser Ser Gln Ser Ala Lys Pro 
                485                 490                 495     


Val Ser Gly Gln Asp Thr Ser Gly Asn Thr Glu Gly Ser Pro Ala Ala 
            500                 505                 510         


Glu Lys Ala Gln Leu Lys Ser Glu Ala Ala Gly Ser Pro Asp Gln Gly 
        515                 520                 525             


Ser Thr Tyr Ser Pro Ala Arg Gly Val Ala Gly Pro Arg Gly Gln Asp 
    530                 535                 540                 


Pro Val Ser Ser Pro Cys Gly 
545                 550     


<210>  931
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  931

Met Pro Pro Ser Ile Ser Ala Phe Gln Ala Ala Tyr Ile Gly Ile Glu 
1               5                   10                  15      


Val Leu Ile Ala Leu Val Ser Val Pro Gly Asn Val Leu Val Ile Trp 
            20                  25                  30          


Ala Val Lys Val Asn Gln Ala Leu Arg Asp Ala Thr Phe Cys Phe Ile 
        35                  40                  45              


Val Ser Leu Ala Val Ala Asp Val Ala Val Gly Ala Leu Val Ile Pro 
    50                  55                  60                  


Leu Ala Ile Leu Ile Asn Ile Gly Pro Gln Thr Tyr Phe His Thr Cys 
65                  70                  75                  80  


Leu Met Val Ala Cys Pro Val Leu Ile Leu Thr Gln Ser Ser Ile Leu 
                85                  90                  95      


Ala Leu Leu Ala Ile Ala Val Asp Arg Tyr Leu Arg Val Lys Ile Pro 
            100                 105                 110         


Leu Arg Tyr Lys Met Val Val Thr Pro Arg Arg Ala Ala Val Ala Ile 
        115                 120                 125             


Ala Gly Cys Trp Ile Leu Ser Phe Val Val Gly Leu Thr Pro Met Phe 
    130                 135                 140                 


Gly Trp Asn Asn Leu Ser Ala Val Glu Arg Ala Trp Ala Ala Asn Gly 
145                 150                 155                 160 


Ser Met Gly Glu Pro Val Ile Lys Cys Glu Phe Glu Lys Val Ile Ser 
                165                 170                 175     


Met Glu Tyr Met Val Tyr Phe Asn Phe Phe Val Trp Val Leu Pro Pro 
            180                 185                 190         


Leu Leu Leu Met Val Leu Ile Tyr Leu Glu Val Phe Tyr Leu Ile Arg 
        195                 200                 205             


Lys Gln Leu Asn Lys Lys Val Ser Ala Ser Ser Gly Asp Pro Gln Lys 
    210                 215                 220                 


Tyr Tyr Gly Lys Glu Leu Lys Ile Ala Lys Ser Leu Ala Leu Ile Leu 
225                 230                 235                 240 


Phe Leu Phe Ala Leu Ser Trp Leu Pro Leu His Ile Leu Asn Cys Ile 
                245                 250                 255     


Thr Leu Phe Cys Pro Ser Cys His Lys Pro Ser Ile Leu Thr Tyr Ile 
            260                 265                 270         


Ala Ile Phe Leu Thr His Gly Asn Ser Ala Met Asn Pro Ile Val Tyr 
        275                 280                 285             


Ala Phe Arg Ile Gln Lys Phe Arg Val Thr Phe Leu Lys Ile Trp Asn 
    290                 295                 300                 


Asp His Phe Arg Cys Gln Pro Ala Pro Pro Ile Asp Glu Asp Leu Pro 
305                 310                 315                 320 


Glu Glu Arg Pro Asp Asp 
                325     


<210>  932
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  932

Met Phe Asp Ile Lys Ala Trp Ala Glu Tyr Val Val Glu Trp Ala Ala 
1               5                   10                  15      


Lys Asp Pro Tyr Gly Phe Leu Thr Thr Val Ile Leu Ala Leu Thr Pro 
            20                  25                  30          


Leu Phe Leu Ala Ser Ala Val Leu Ser Trp Lys Leu Ala Lys Met Ile 
        35                  40                  45              


Glu Ala Arg Glu Lys Glu Gln Lys Lys Lys Gln Lys Arg Gln Glu Asn 
    50                  55                  60                  


Ile Ala Lys Ala Lys Arg Leu Lys Lys Asp 
65                  70                  


<210>  933
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  933

Met Trp Pro Pro Asp Pro Asp Pro Asp Pro Asp Pro Glu Pro Ala Gly 
1               5                   10                  15      


Gly Ser Arg Pro Gly Pro Ala Val Pro Gly Leu Arg Ala Leu Leu Pro 
            20                  25                  30          


Ala Arg Ala Phe Leu Cys Ser Leu Lys Gly Arg Leu Leu Leu Ala Glu 
        35                  40                  45              


Ser Gly Leu Ser Phe Ile Thr Phe Ile Cys Tyr Val Ala Ser Ser Ala 
    50                  55                  60                  


Ser Ala Phe Leu Thr Ala Pro Leu Leu Glu Phe Leu Leu Ala Leu Tyr 
65                  70                  75                  80  


Phe Leu Phe Ala Asp Ala Met Gln Leu Asn Asp Lys Trp Gln Gly Leu 
                85                  90                  95      


Cys Trp Pro Met Met Asp Phe Leu Arg Cys Val Thr Ala Ala Leu Ile 
            100                 105                 110         


Tyr Phe Ala Ile Ser Ile Thr Ala Ile Ala Lys Tyr Ser Asp Gly Ala 
        115                 120                 125             


Ser Lys Ala Ala Gly Val Phe Gly Phe Phe Ala Thr Ile Val Phe Ala 
    130                 135                 140                 


Thr Asp Phe Tyr Leu Ile Phe Asn Asp Val Ala Lys Phe Leu Lys Gln 
145                 150                 155                 160 


Gly Asp Ser Ala Asp Glu Thr Thr Ala His Lys Thr Glu Glu Glu Asn 
                165                 170                 175     


Ser Asp Ser Asp Ser Asp 
            180         


<210>  934
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  934

Met Asp Gly Gly Gln Pro Ile Pro Ser Ser Leu Val Pro Leu Gly Asn 
1               5                   10                  15      


Glu Ser Ala Asp Ser Ser Met Ser Leu Glu Gln Lys Met Thr Phe Val 
            20                  25                  30          


Phe Val Ile Leu Leu Phe Ile Phe Leu Gly Ile Leu Ile Val Arg Cys 
        35                  40                  45              


Phe Arg Ile Leu Leu Asp Pro Tyr Arg Ser Met Pro Thr Ser Thr Trp 
    50                  55                  60                  


Ala Asp Gly Leu Glu Gly Leu Glu Lys Gly Gln Phe Asp His Ala Leu 
65                  70                  75                  80  


Ala 
    


<210>  935
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  935

Met Asp Met Leu His Pro Ser Ser Val Ser Thr Thr Ser Glu Pro Glu 
1               5                   10                  15      


Asn Ala Ser Ser Ala Trp Pro Pro Asp Ala Thr Leu Gly Asn Val Ser 
            20                  25                  30          


Ala Gly Pro Ser Pro Ala Gly Leu Ala Val Ser Gly Val Leu Ile Pro 
        35                  40                  45              


Leu Val Tyr Leu Val Val Cys Val Val Gly Leu Leu Gly Asn Ser Leu 
    50                  55                  60                  


Val Ile Tyr Val Val Leu Arg His Thr Ala Ser Pro Ser Val Thr Asn 
65                  70                  75                  80  


Val Tyr Ile Leu Asn Leu Ala Leu Ala Asp Glu Leu Phe Met Leu Gly 
                85                  90                  95      


Leu Pro Phe Leu Ala Ala Gln Asn Ala Leu Ser Tyr Trp Pro Phe Gly 
            100                 105                 110         


Ser Leu Met Cys Arg Leu Val Met Ala Val Asp Gly Ile Asn Gln Phe 
        115                 120                 125             


Thr Ser Ile Phe Cys Leu Thr Val Met Ser Val Asp Arg Tyr Leu Ala 
    130                 135                 140                 


Val Val His Pro Thr Arg Ser Ala Arg Trp Arg Thr Ala Pro Val Ala 
145                 150                 155                 160 


Arg Thr Val Ser Ala Ala Val Trp Val Ala Ser Ala Val Val Val Leu 
                165                 170                 175     


Pro Val Val Val Phe Ser Gly Val Pro Arg Gly Met Ser Thr Cys His 
            180                 185                 190         


Met Gln Trp Pro Glu Pro Ala Ala Ala Trp Arg Ala Gly Phe Ile Ile 
        195                 200                 205             


Tyr Thr Ala Ala Leu Gly Phe Phe Gly Pro Leu Leu Val Ile Cys Leu 
    210                 215                 220                 


Cys Tyr Leu Leu Ile Val Val Lys Val Arg Ser Ala Gly Arg Arg Val 
225                 230                 235                 240 


Trp Ala Pro Ser Cys Gln Arg Arg Arg Arg Ser Glu Arg Arg Val Thr 
                245                 250                 255     


Arg Met Val Val Ala Val Val Ala Leu Phe Val Leu Cys Trp Met Pro 
            260                 265                 270         


Phe Tyr Val Leu Asn Ile Val Asn Val Val Cys Pro Leu Pro Glu Glu 
        275                 280                 285             


Pro Ala Phe Phe Gly Leu Tyr Phe Leu Val Val Ala Leu Pro Tyr Ala 
    290                 295                 300                 


Asn Ser Cys Ala Asn Pro Ile Leu Tyr Gly Phe Leu Ser Tyr Arg Phe 
305                 310                 315                 320 


Lys Gln Gly Phe Arg Arg Val Leu Leu Arg Pro Ser Arg Arg Val Arg 
                325                 330                 335     


Ser Gln Glu Pro Thr Val Gly Pro Pro Glu Lys Thr Glu Glu Glu Asp 
            340                 345                 350         


Glu Glu Glu Glu Asp Gly Glu Glu Ser Arg Glu Gly Gly Lys Gly Lys 
        355                 360                 365             


Glu Met Asn Gly Arg Val Ser Gln Ile Thr Gln Pro Gly Thr Ser Gly 
    370                 375                 380                 


Gln Glu Arg Pro Pro Ser Arg Val Ala Ser Lys Glu Gln Gln Leu Leu 
385                 390                 395                 400 


Pro Gln Glu Ala Ser Thr Gly Glu Lys Ser Ser Thr Met Arg Ile Ser 
                405                 410                 415     


Tyr Leu 
        


<210>  936
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  936

Met Ser Ala Pro Ser Thr Leu Pro Pro Gly Gly Glu Glu Gly Leu Gly 
1               5                   10                  15      


Thr Ala Trp Pro Ser Ala Ala Asn Ala Ser Ser Ala Pro Ala Glu Ala 
            20                  25                  30          


Glu Glu Ala Val Ala Gly Pro Gly Asp Ala Arg Ala Ala Gly Met Val 
        35                  40                  45              


Ala Ile Gln Cys Ile Tyr Ala Leu Val Cys Leu Val Gly Leu Val Gly 
    50                  55                  60                  


Asn Ala Leu Val Ile Phe Val Ile Leu Arg Tyr Ala Lys Met Lys Thr 
65                  70                  75                  80  


Ala Thr Asn Ile Tyr Leu Leu Asn Leu Ala Val Ala Asp Glu Leu Phe 
                85                  90                  95      


Met Leu Ser Val Pro Phe Val Ala Ser Ser Ala Ala Leu Arg His Trp 
            100                 105                 110         


Pro Phe Gly Ser Val Leu Cys Arg Ala Val Leu Ser Val Asp Gly Leu 
        115                 120                 125             


Asn Met Phe Thr Ser Val Phe Cys Leu Thr Val Leu Ser Val Asp Arg 
    130                 135                 140                 


Tyr Val Ala Val Val His Pro Leu Arg Ala Ala Thr Tyr Arg Arg Pro 
145                 150                 155                 160 


Ser Val Ala Lys Leu Ile Asn Leu Gly Val Trp Leu Ala Ser Leu Leu 
                165                 170                 175     


Val Thr Leu Pro Ile Ala Ile Phe Ala Asp Thr Arg Pro Ala Arg Gly 
            180                 185                 190         


Gly Gln Ala Val Ala Cys Asn Leu Gln Trp Pro His Pro Ala Trp Ser 
        195                 200                 205             


Ala Val Phe Val Val Tyr Thr Phe Leu Leu Gly Phe Leu Leu Pro Val 
    210                 215                 220                 


Leu Ala Ile Gly Leu Cys Tyr Leu Leu Ile Val Gly Lys Met Arg Ala 
225                 230                 235                 240 


Val Ala Leu Arg Ala Gly Trp Gln Gln Arg Arg Arg Ser Glu Lys Lys 
                245                 250                 255     


Ile Thr Arg Leu Val Leu Met Val Val Val Val Phe Val Leu Cys Trp 
            260                 265                 270         


Met Pro Phe Tyr Val Val Gln Leu Leu Asn Leu Phe Val Thr Ser Leu 
        275                 280                 285             


Asp Ala Thr Val Asn His Val Ser Leu Ile Leu Ser Tyr Ala Asn Ser 
    290                 295                 300                 


Cys Ala Asn Pro Ile Leu Tyr Gly Phe Leu Ser Asp Asn Phe Arg Arg 
305                 310                 315                 320 


Phe Phe Gln Arg Val Leu Cys Leu Arg Cys Cys Leu Leu Glu Gly Ala 
                325                 330                 335     


Gly Gly Ala Glu Glu Glu Pro Leu Asp Tyr Tyr Ala Thr Ala Leu Lys 
            340                 345                 350         


Ser Lys Gly Gly Ala Gly Cys Met Cys Pro Pro Leu Pro Cys Gln Gln 
        355                 360                 365             


Glu Ala Leu Gln Pro Glu Pro Gly Arg Lys Arg Ile Pro Leu Thr Arg 
    370                 375                 380                 


Thr Thr Thr Phe 
385             


<210>  937
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  937

Met Glu Pro Leu Phe Pro Ala Ser Thr Pro Ser Trp Asn Ala Ser Ser 
1               5                   10                  15      


Pro Gly Ala Ala Ser Gly Gly Gly Asp Asn Arg Thr Leu Val Gly Pro 
            20                  25                  30          


Ala Pro Ser Ala Gly Ala Arg Ala Val Leu Val Pro Val Leu Tyr Leu 
        35                  40                  45              


Leu Val Cys Ala Ala Gly Leu Gly Gly Asn Thr Leu Val Ile Tyr Val 
    50                  55                  60                  


Val Leu Arg Phe Ala Lys Met Lys Thr Val Thr Asn Ile Tyr Ile Leu 
65                  70                  75                  80  


Asn Leu Ala Val Ala Asp Val Leu Tyr Met Leu Gly Leu Pro Phe Leu 
                85                  90                  95      


Ala Thr Gln Asn Ala Ala Ser Phe Trp Pro Phe Gly Pro Val Leu Cys 
            100                 105                 110         


Arg Leu Val Met Thr Leu Asp Gly Val Asn Gln Phe Thr Ser Val Phe 
        115                 120                 125             


Cys Leu Thr Val Met Ser Val Asp Arg Tyr Leu Ala Val Val His Pro 
    130                 135                 140                 


Leu Ser Ser Ala Arg Trp Arg Arg Pro Arg Val Ala Lys Leu Ala Ser 
145                 150                 155                 160 


Ala Ala Ala Trp Val Leu Ser Leu Cys Met Ser Leu Pro Leu Leu Val 
                165                 170                 175     


Phe Ala Asp Val Gln Glu Gly Gly Thr Cys Asn Ala Ser Trp Pro Glu 
            180                 185                 190         


Pro Val Gly Leu Trp Gly Ala Val Phe Ile Ile Tyr Thr Ala Val Leu 
        195                 200                 205             


Gly Phe Phe Ala Pro Leu Leu Val Ile Cys Leu Cys Tyr Leu Leu Ile 
    210                 215                 220                 


Val Val Lys Val Arg Ala Ala Gly Val Arg Val Gly Cys Val Arg Arg 
225                 230                 235                 240 


Arg Ser Glu Arg Lys Val Thr Arg Met Val Leu Val Val Val Leu Val 
                245                 250                 255     


Phe Ala Gly Cys Trp Leu Pro Phe Phe Thr Val Asn Ile Val Asn Leu 
            260                 265                 270         


Ala Val Ala Leu Pro Gln Glu Pro Ala Ser Ala Gly Leu Tyr Phe Phe 
        275                 280                 285             


Val Val Ile Leu Ser Tyr Ala Asn Ser Cys Ala Asn Pro Val Leu Tyr 
    290                 295                 300                 


Gly Phe Leu Ser Asp Asn Phe Arg Gln Ser Phe Gln Lys Val Leu Cys 
305                 310                 315                 320 


Leu Arg Lys Gly Ser Gly Ala Lys Asp Ala Asp Ala Thr Glu Pro Arg 
                325                 330                 335     


Pro Asp Arg Ile Arg Gln Gln Gln Glu Ala Thr Pro Pro Ala His Arg 
            340                 345                 350         


Ala Ala Ala Asn Gly Leu Met Gln Thr Ser Lys Leu 
        355                 360                 


<210>  938
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  938

Met Gly Thr Cys Asp Ile Val Thr Glu Ala Asn Ile Ser Ser Gly Pro 
1               5                   10                  15      


Glu Ser Asn Thr Thr Gly Ile Thr Ala Phe Ser Met Pro Ser Trp Gln 
            20                  25                  30          


Leu Ala Leu Trp Ala Thr Ala Tyr Leu Ala Leu Val Leu Val Ala Val 
        35                  40                  45              


Thr Gly Asn Ala Ile Val Ile Trp Ile Ile Leu Ala His Arg Arg Met 
    50                  55                  60                  


Arg Thr Val Thr Asn Tyr Phe Ile Val Asn Leu Ala Leu Ala Asp Leu 
65                  70                  75                  80  


Cys Met Ala Ala Phe Asn Ala Ala Phe Asn Phe Val Tyr Ala Ser His 
                85                  90                  95      


Asn Ile Trp Tyr Phe Gly Arg Ala Phe Cys Tyr Phe Gln Asn Leu Phe 
            100                 105                 110         


Pro Ile Thr Ala Met Phe Val Ser Ile Tyr Ser Met Thr Ala Ile Ala 
        115                 120                 125             


Ala Asp Arg Tyr Met Ala Ile Val His Pro Phe Gln Pro Arg Leu Ser 
    130                 135                 140                 


Ala Pro Ser Thr Lys Ala Val Ile Ala Gly Ile Trp Leu Val Ala Leu 
145                 150                 155                 160 


Ala Leu Ala Ser Pro Gln Cys Phe Tyr Ser Thr Val Thr Met Asp Gln 
                165                 170                 175     


Gly Ala Thr Lys Cys Val Val Ala Trp Pro Glu Asp Ser Gly Gly Lys 
            180                 185                 190         


Thr Leu Leu Leu Tyr His Leu Val Val Ile Ala Leu Ile Tyr Phe Leu 
        195                 200                 205             


Pro Leu Ala Val Met Phe Val Ala Tyr Ser Val Ile Gly Leu Thr Leu 
    210                 215                 220                 


Trp Arg Arg Ala Val Pro Gly His Gln Ala His Gly Ala Asn Leu Arg 
225                 230                 235                 240 


His Leu Gln Ala Met Lys Lys Phe Val Lys Thr Met Val Leu Val Val 
                245                 250                 255     


Leu Thr Phe Ala Ile Cys Trp Leu Pro Tyr His Leu Tyr Phe Ile Leu 
            260                 265                 270         


Gly Ser Phe Gln Glu Asp Ile Tyr Cys His Lys Phe Ile Gln Gln Val 
        275                 280                 285             


Tyr Leu Ala Leu Phe Trp Leu Ala Met Ser Ser Thr Met Tyr Asn Pro 
    290                 295                 300                 


Ile Ile Tyr Cys Cys Leu Asn His Arg Phe Arg Ser Gly Phe Arg Leu 
305                 310                 315                 320 


Ala Phe Arg Cys Cys Pro Trp Val Thr Pro Thr Lys Glu Asp Lys Leu 
                325                 330                 335     


Glu Leu Thr Pro Thr Thr Ser Leu Ser Thr Arg Val Asn Arg Cys His 
            340                 345                 350         


Thr Lys Glu Thr Leu Phe Met Ala Gly Asp Thr Ala Pro Ser Glu Ala 
        355                 360                 365             


Thr Ser Gly Glu Ala Gly Arg Pro Gln Asp Gly Ser Gly Leu Trp Phe 
    370                 375                 380                 


Gly Tyr Gly Leu Leu Ala Pro Thr Lys Thr His Val Glu Ile 
385                 390                 395             


<210>  939
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  939

Met Asp Asn Val Leu Pro Val Asp Ser Asp Leu Ser Pro Asn Ile Ser 
1               5                   10                  15      


Thr Asn Thr Ser Glu Pro Asn Gln Phe Val Gln Pro Ala Trp Gln Ile 
            20                  25                  30          


Val Leu Trp Ala Ala Ala Tyr Thr Val Ile Val Val Thr Ser Val Val 
        35                  40                  45              


Gly Asn Val Val Val Met Trp Ile Ile Leu Ala His Lys Arg Met Arg 
    50                  55                  60                  


Thr Val Thr Asn Tyr Phe Leu Val Asn Leu Ala Phe Ala Glu Ala Ser 
65                  70                  75                  80  


Met Ala Ala Phe Asn Thr Val Val Asn Phe Thr Tyr Ala Val His Asn 
                85                  90                  95      


Glu Trp Tyr Tyr Gly Leu Phe Tyr Cys Lys Phe His Asn Phe Phe Pro 
            100                 105                 110         


Ile Ala Ala Val Phe Ala Ser Ile Tyr Ser Met Thr Ala Val Ala Phe 
        115                 120                 125             


Asp Arg Tyr Met Ala Ile Ile His Pro Leu Gln Pro Arg Leu Ser Ala 
    130                 135                 140                 


Thr Ala Thr Lys Val Val Ile Cys Val Ile Trp Val Leu Ala Leu Leu 
145                 150                 155                 160 


Leu Ala Phe Pro Gln Gly Tyr Tyr Ser Thr Thr Glu Thr Met Pro Ser 
                165                 170                 175     


Arg Val Val Cys Met Ile Glu Trp Pro Glu His Pro Asn Lys Ile Tyr 
            180                 185                 190         


Glu Lys Val Tyr His Ile Cys Val Thr Val Leu Ile Tyr Phe Leu Pro 
        195                 200                 205             


Leu Leu Val Ile Gly Tyr Ala Tyr Thr Val Val Gly Ile Thr Leu Trp 
    210                 215                 220                 


Ala Ser Glu Ile Pro Gly Asp Ser Ser Asp Arg Tyr His Glu Gln Val 
225                 230                 235                 240 


Ser Ala Lys Arg Lys Val Val Lys Met Met Ile Val Val Val Cys Thr 
                245                 250                 255     


Phe Ala Ile Cys Trp Leu Pro Phe His Ile Phe Phe Leu Leu Pro Tyr 
            260                 265                 270         


Ile Asn Pro Asp Leu Tyr Leu Lys Lys Phe Ile Gln Gln Val Tyr Leu 
        275                 280                 285             


Ala Ile Met Trp Leu Ala Met Ser Ser Thr Met Tyr Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Cys Cys Leu Asn Asp Arg Phe Arg Leu Gly Phe Lys His Ala Phe 
305                 310                 315                 320 


Arg Cys Cys Pro Phe Ile Ser Ala Gly Asp Tyr Glu Gly Leu Glu Met 
                325                 330                 335     


Lys Ser Thr Arg Tyr Leu Gln Thr Gln Gly Ser Val Tyr Lys Val Ser 
            340                 345                 350         


Arg Leu Glu Thr Thr Ile Ser Thr Val Val Gly Ala His Glu Glu Glu 
        355                 360                 365             


Pro Glu Asp Gly Pro Lys Ala Thr Pro Ser Ser Leu Asp Leu Thr Ser 
    370                 375                 380                 


Asn Cys Ser Ser Arg Ser Asp Ser Lys Thr Met Thr Glu Ser Phe Ser 
385                 390                 395                 400 


Phe Ser Ser Asn Val Leu Ser 
                405         


<210>  940
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  940

Met Ala Thr Leu Pro Ala Ala Glu Thr Trp Ile Asp Gly Gly Gly Gly 
1               5                   10                  15      


Val Gly Ala Asp Ala Val Asn Leu Thr Ala Ser Leu Ala Ala Gly Ala 
            20                  25                  30          


Ala Thr Gly Ala Val Glu Thr Gly Trp Leu Gln Leu Leu Asp Gln Ala 
        35                  40                  45              


Gly Asn Leu Ser Ser Ser Pro Ser Ala Leu Gly Leu Pro Val Ala Ser 
    50                  55                  60                  


Pro Ala Pro Ser Gln Pro Trp Ala Asn Leu Thr Asn Gln Phe Val Gln 
65                  70                  75                  80  


Pro Ser Trp Arg Ile Ala Leu Trp Ser Leu Ala Tyr Gly Val Val Val 
                85                  90                  95      


Ala Val Ala Val Leu Gly Asn Leu Ile Val Ile Trp Ile Ile Leu Ala 
            100                 105                 110         


His Lys Arg Met Arg Thr Val Thr Asn Tyr Phe Leu Val Asn Leu Ala 
        115                 120                 125             


Phe Ser Asp Ala Ser Met Ala Ala Phe Asn Thr Leu Val Asn Phe Ile 
    130                 135                 140                 


Tyr Ala Leu His Ser Glu Trp Tyr Phe Gly Ala Asn Tyr Cys Arg Phe 
145                 150                 155                 160 


Gln Asn Phe Phe Pro Ile Thr Ala Val Phe Ala Ser Ile Tyr Ser Met 
                165                 170                 175     


Thr Ala Ile Ala Val Asp Arg Tyr Met Ala Ile Ile Asp Pro Leu Lys 
            180                 185                 190         


Pro Arg Leu Ser Ala Thr Ala Thr Lys Ile Val Ile Gly Ser Ile Trp 
        195                 200                 205             


Ile Leu Ala Phe Leu Leu Ala Phe Pro Gln Cys Leu Tyr Ser Lys Thr 
    210                 215                 220                 


Lys Val Met Pro Gly Arg Thr Leu Cys Phe Val Gln Trp Pro Glu Gly 
225                 230                 235                 240 


Pro Lys Gln His Phe Thr Tyr His Ile Ile Val Ile Ile Leu Val Tyr 
                245                 250                 255     


Cys Phe Pro Leu Leu Ile Met Gly Ile Thr Tyr Thr Ile Val Gly Ile 
            260                 265                 270         


Thr Leu Trp Gly Gly Glu Ile Pro Gly Asp Thr Cys Asp Lys Tyr His 
        275                 280                 285             


Glu Gln Leu Lys Ala Lys Arg Lys Val Val Lys Met Met Ile Ile Val 
    290                 295                 300                 


Val Met Thr Phe Ala Ile Cys Trp Leu Pro Tyr His Ile Tyr Phe Ile 
305                 310                 315                 320 


Leu Thr Ala Ile Tyr Gln Gln Leu Asn Arg Trp Lys Tyr Ile Gln Gln 
                325                 330                 335     


Val Tyr Leu Ala Ser Phe Trp Leu Ala Met Ser Ser Thr Met Tyr Asn 
            340                 345                 350         


Pro Ile Ile Tyr Cys Cys Leu Asn Lys Arg Phe Arg Ala Gly Phe Lys 
        355                 360                 365             


Arg Ala Phe Arg Trp Cys Pro Phe Ile Lys Val Ser Ser Tyr Asp Glu 
    370                 375                 380                 


Leu Glu Leu Lys Thr Thr Arg Phe His Pro Asn Arg Gln Ser Ser Met 
385                 390                 395                 400 


Tyr Thr Val Thr Arg Met Glu Ser Met Thr Val Val Phe Asp Pro Asn 
                405                 410                 415     


Asp Ala Asp Thr Thr Arg Ser Ser Arg Lys Lys Arg Ala Thr Pro Arg 
            420                 425                 430         


Asp Pro Ser Phe Asn Gly Cys Ser Arg Arg Asn Ser Lys Ser Ala Ser 
        435                 440                 445             


Ala Thr Ser Ser Phe Ile Ser Ser Pro Tyr Thr Ser Val Asp Glu Tyr 
    450                 455                 460                 


Ser 
465 


<210>  941
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  941

Met Gly Leu Ser Thr Val Pro Asp Leu Leu Leu Pro Leu Val Leu Leu 
1               5                   10                  15      


Glu Leu Leu Val Gly Ile Tyr Pro Ser Gly Val Ile Gly Leu Val Pro 
            20                  25                  30          


His Leu Gly Asp Arg Glu Lys Arg Asp Ser Val Cys Pro Gln Gly Lys 
        35                  40                  45              


Tyr Ile His Pro Gln Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys 
    50                  55                  60                  


Gly Thr Tyr Leu Tyr Asn Asp Cys Pro Gly Pro Gly Gln Asp Thr Asp 
65                  70                  75                  80  


Cys Arg Glu Cys Glu Ser Gly Ser Phe Thr Ala Ser Glu Asn His Leu 
                85                  90                  95      


Arg His Cys Leu Ser Cys Ser Lys Cys Arg Lys Glu Met Gly Gln Val 
            100                 105                 110         


Glu Ile Ser Ser Cys Thr Val Asp Arg Asp Thr Val Cys Gly Cys Arg 
        115                 120                 125             


Lys Asn Gln Tyr Arg His Tyr Trp Ser Glu Asn Leu Phe Gln Cys Phe 
    130                 135                 140                 


Asn Cys Ser Leu Cys Leu Asn Gly Thr Val His Leu Ser Cys Gln Glu 
145                 150                 155                 160 


Lys Gln Asn Thr Val Cys Thr Cys His Ala Gly Phe Phe Leu Arg Glu 
                165                 170                 175     


Asn Glu Cys Val Ser Cys Ser Asn Cys Lys Lys Ser Leu Glu Cys Thr 
            180                 185                 190         


Lys Leu Cys Leu Pro Gln Ile Glu Asn Val Lys Gly Thr Glu Asp Ser 
        195                 200                 205             


Gly Thr Thr Val Leu Leu Pro Leu Val Ile Phe Phe Gly Leu Cys Leu 
    210                 215                 220                 


Leu Ser Leu Leu Phe Ile Gly Leu Met Tyr Arg Tyr Gln Arg Trp Lys 
225                 230                 235                 240 


Ser Lys Leu Tyr Ser Ile Val Cys Gly Lys Ser Thr Pro Glu Lys Glu 
                245                 250                 255     


Gly Glu Leu Glu Gly Thr Thr Thr Lys Pro Leu Ala Pro Asn Pro Ser 
            260                 265                 270         


Phe Ser Pro Thr Pro Gly Phe Thr Pro Thr Leu Gly Phe Ser Pro Val 
        275                 280                 285             


Pro Ser Ser Thr Phe Thr Ser Ser Ser Thr Tyr Thr Pro Gly Asp Cys 
    290                 295                 300                 


Pro Asn Phe Ala Ala Pro Arg Arg Glu Val Ala Pro Pro Tyr Gln Gly 
305                 310                 315                 320 


Ala Asp Pro Ile Leu Ala Thr Ala Leu Ala Ser Asp Pro Ile Pro Asn 
                325                 330                 335     


Pro Leu Gln Lys Trp Glu Asp Ser Ala His Lys Pro Gln Ser Leu Asp 
            340                 345                 350         


Thr Asp Asp Pro Ala Thr Leu Tyr Ala Val Val Glu Asn Val Pro Pro 
        355                 360                 365             


Leu Arg Trp Lys Glu Phe Val Arg Arg Leu Gly Leu Ser Asp His Glu 
    370                 375                 380                 


Ile Asp Arg Leu Glu Leu Gln Asn Gly Arg Cys Leu Arg Glu Ala Gln 
385                 390                 395                 400 


Tyr Ser Met Leu Ala Thr Trp Arg Arg Arg Thr Pro Arg Arg Glu Ala 
                405                 410                 415     


Thr Leu Glu Leu Leu Gly Arg Val Leu Arg Asp Met Asp Leu Leu Gly 
            420                 425                 430         


Cys Leu Glu Asp Ile Glu Glu Ala Leu Cys Gly Pro Ala Ala Leu Pro 
        435                 440                 445             


Pro Ala Pro Ser Leu Leu Arg 
    450                 455 


<210>  942
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  942

Met Ala Pro Val Ala Val Trp Ala Ala Leu Ala Val Gly Leu Glu Leu 
1               5                   10                  15      


Trp Ala Ala Ala His Ala Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr 
            20                  25                  30          


Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln 
        35                  40                  45              


Thr Ala Gln Met Cys Cys Ser Lys Cys Ser Pro Gly Gln His Ala Lys 
    50                  55                  60                  


Val Phe Cys Thr Lys Thr Ser Asp Thr Val Cys Asp Ser Cys Glu Asp 
65                  70                  75                  80  


Ser Thr Tyr Thr Gln Leu Trp Asn Trp Val Pro Glu Cys Leu Ser Cys 
                85                  90                  95      


Gly Ser Arg Cys Ser Ser Asp Gln Val Glu Thr Gln Ala Cys Thr Arg 
            100                 105                 110         


Glu Gln Asn Arg Ile Cys Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu 
        115                 120                 125             


Ser Lys Gln Glu Gly Cys Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg 
    130                 135                 140                 


Pro Gly Phe Gly Val Ala Arg Pro Gly Thr Glu Thr Ser Asp Val Val 
145                 150                 155                 160 


Cys Lys Pro Cys Ala Pro Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr 
                165                 170                 175     


Asp Ile Cys Arg Pro His Gln Ile Cys Asn Val Val Ala Ile Pro Gly 
            180                 185                 190         


Asn Ala Ser Met Asp Ala Val Cys Thr Ser Thr Ser Pro Thr Arg Ser 
        195                 200                 205             


Met Ala Pro Gly Ala Val His Leu Pro Gln Pro Val Ser Thr Arg Ser 
    210                 215                 220                 


Gln His Thr Gln Pro Thr Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser 
225                 230                 235                 240 


Phe Leu Leu Pro Met Gly Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly 
                245                 250                 255     


Asp Phe Ala Leu Pro Val Gly Leu Ile Val Gly Val Thr Ala Leu Gly 
            260                 265                 270         


Leu Leu Ile Ile Gly Val Val Asn Cys Val Ile Met Thr Gln Val Lys 
        275                 280                 285             


Lys Lys Pro Leu Cys Leu Gln Arg Glu Ala Lys Val Pro His Leu Pro 
    290                 295                 300                 


Ala Asp Lys Ala Arg Gly Thr Gln Gly Pro Glu Gln Gln His Leu Leu 
305                 310                 315                 320 


Ile Thr Ala Pro Ser Ser Ser Ser Ser Ser Leu Glu Ser Ser Ala Ser 
                325                 330                 335     


Ala Leu Asp Arg Arg Ala Pro Thr Arg Asn Gln Pro Gln Ala Pro Gly 
            340                 345                 350         


Val Glu Ala Ser Gly Ala Gly Glu Ala Arg Ala Ser Thr Gly Ser Ser 
        355                 360                 365             


Asp Ser Ser Pro Gly Gly His Gly Thr Gln Val Asn Val Thr Cys Ile 
    370                 375                 380                 


Val Asn Val Cys Ser Ser Ser Asp His Ser Ser Gln Cys Ser Ser Gln 
385                 390                 395                 400 


Ala Ser Ser Thr Met Gly Asp Thr Asp Ser Ser Pro Ser Glu Ser Pro 
                405                 410                 415     


Lys Asp Glu Gln Val Pro Phe Ser Lys Glu Glu Cys Ala Phe Arg Ser 
            420                 425                 430         


Gln Leu Glu Thr Pro Glu Thr Leu Leu Gly Ser Thr Glu Glu Lys Pro 
        435                 440                 445             


Leu Pro Leu Gly Val Pro Asp Ala Gly Met Lys Pro Ser 
    450                 455                 460     


<210>  943
<211>  532
<212>  PRT
<213>  Homo sapiens

<400>  943

Met Ala Cys Leu Leu Arg Ser Phe Gln Arg Ile Ser Ala Gly Val Phe 
1               5                   10                  15      


Phe Leu Ala Leu Trp Gly Met Val Val Gly Asp Lys Leu Leu Val Val 
            20                  25                  30          


Pro Gln Asp Gly Ser His Trp Leu Ser Met Lys Asp Ile Val Glu Val 
        35                  40                  45              


Leu Ser Asp Arg Gly His Glu Ile Val Val Val Val Pro Glu Val Asn 
    50                  55                  60                  


Leu Leu Leu Lys Glu Ser Lys Tyr Tyr Thr Arg Lys Ile Tyr Pro Val 
65                  70                  75                  80  


Pro Tyr Asp Gln Glu Glu Leu Lys Asn Arg Tyr Gln Ser Phe Gly Asn 
                85                  90                  95      


Asn His Phe Ala Glu Arg Ser Phe Leu Thr Ala Pro Gln Thr Glu Tyr 
            100                 105                 110         


Arg Asn Asn Met Ile Val Ile Gly Leu Tyr Phe Ile Asn Cys Gln Ser 
        115                 120                 125             


Leu Leu Gln Asp Arg Asp Thr Leu Asn Phe Phe Lys Glu Ser Lys Phe 
    130                 135                 140                 


Asp Ala Leu Phe Thr Asp Pro Ala Leu Pro Cys Gly Val Ile Leu Ala 
145                 150                 155                 160 


Glu Tyr Leu Gly Leu Pro Ser Val Tyr Leu Phe Arg Gly Phe Pro Cys 
                165                 170                 175     


Ser Leu Glu His Thr Phe Ser Arg Ser Pro Asp Pro Val Ser Tyr Ile 
            180                 185                 190         


Pro Arg Cys Tyr Thr Lys Phe Ser Asp His Met Thr Phe Ser Gln Arg 
        195                 200                 205             


Val Ala Asn Phe Leu Val Asn Leu Leu Glu Pro Tyr Leu Phe Tyr Cys 
    210                 215                 220                 


Leu Phe Ser Lys Tyr Glu Glu Leu Ala Ser Ala Val Leu Lys Arg Asp 
225                 230                 235                 240 


Val Asp Ile Ile Thr Leu Tyr Gln Lys Val Ser Val Trp Leu Leu Arg 
                245                 250                 255     


Tyr Asp Phe Val Leu Glu Tyr Pro Arg Pro Val Met Pro Asn Met Val 
            260                 265                 270         


Phe Ile Gly Gly Ile Asn Cys Lys Lys Arg Lys Asp Leu Ser Gln Glu 
        275                 280                 285             


Phe Glu Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val Val Phe 
    290                 295                 300                 


Ser Leu Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala Met Ala 
305                 310                 315                 320 


Ile Ala Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp Arg Tyr 
                325                 330                 335     


Thr Gly Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu Val Lys 
            340                 345                 350         


Trp Leu Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg Ala Phe 
        355                 360                 365             


Ile Thr His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys Asn Gly 
    370                 375                 380                 


Val Pro Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp Asn Ala 
385                 390                 395                 400 


Lys Arg Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val Leu Glu 
                405                 410                 415     


Met Thr Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile Asn Asp 
            420                 425                 430         


Lys Ser Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His Lys Asp 
        435                 440                 445             


Arg Pro Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu Phe Val 
    450                 455                 460                 


Met Arg His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His Asp Leu 
465                 470                 475                 480 


Thr Trp Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu Leu Ala 
                485                 490                 495     


Val Val Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala Tyr Gly 
            500                 505                 510         


Tyr Arg Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala His Lys 
        515                 520                 525             


Ser Lys Thr His 
    530         


<210>  944
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  944

Met Ser Leu Lys Trp Thr Ser Val Phe Leu Leu Ile Gln Leu Ser Cys 
1               5                   10                  15      


Tyr Phe Ser Ser Gly Ser Cys Gly Lys Val Leu Val Trp Pro Thr Glu 
            20                  25                  30          


Tyr Ser His Trp Ile Asn Met Lys Thr Ile Leu Glu Glu Leu Val Gln 
        35                  40                  45              


Arg Gly His Glu Val Thr Val Leu Thr Ser Ser Ala Ser Thr Leu Val 
    50                  55                  60                  


Asn Ala Ser Lys Ser Ser Ala Ile Lys Leu Glu Val Tyr Pro Thr Ser 
65                  70                  75                  80  


Leu Thr Lys Asn Tyr Leu Glu Asp Ser Leu Leu Lys Ile Leu Asp Arg 
                85                  90                  95      


Trp Ile Tyr Gly Val Ser Lys Asn Thr Phe Trp Ser Tyr Phe Ser Gln 
            100                 105                 110         


Leu Gln Glu Leu Cys Trp Glu Tyr Tyr Asp Tyr Ser Asn Lys Leu Cys 
        115                 120                 125             


Lys Asp Ala Val Leu Asn Lys Lys Leu Met Met Lys Leu Gln Glu Ser 
    130                 135                 140                 


Lys Phe Asp Val Ile Leu Ala Asp Ala Leu Asn Pro Cys Gly Glu Leu 
145                 150                 155                 160 


Leu Ala Glu Leu Phe Asn Ile Pro Phe Leu Tyr Ser Leu Arg Phe Ser 
                165                 170                 175     


Val Gly Tyr Thr Phe Glu Lys Asn Gly Gly Gly Phe Leu Phe Pro Pro 
            180                 185                 190         


Ser Tyr Val Pro Val Val Met Ser Glu Leu Ser Asp Gln Met Ile Phe 
        195                 200                 205             


Met Glu Arg Ile Lys Asn Met Ile His Met Leu Tyr Phe Asp Phe Trp 
    210                 215                 220                 


Phe Gln Ile Tyr Asp Leu Lys Lys Trp Asp Gln Phe Tyr Ser Glu Val 
225                 230                 235                 240 


Leu Gly Arg Pro Thr Thr Leu Phe Glu Thr Met Gly Lys Ala Glu Met 
                245                 250                 255     


Trp Leu Ile Arg Thr Tyr Trp Asp Phe Glu Phe Pro Arg Pro Phe Leu 
            260                 265                 270         


Pro Asn Val Asp Phe Val Gly Gly Leu His Cys Lys Pro Ala Lys Pro 
        275                 280                 285             


Leu Pro Lys Glu Met Glu Glu Phe Val Gln Ser Ser Gly Glu Asn Gly 
    290                 295                 300                 


Ile Val Val Phe Ser Leu Gly Ser Met Ile Ser Asn Met Ser Glu Glu 
305                 310                 315                 320 


Ser Ala Asn Met Ile Ala Ser Ala Leu Ala Gln Ile Pro Gln Lys Val 
                325                 330                 335     


Leu Trp Arg Phe Asp Gly Lys Lys Pro Asn Thr Leu Gly Ser Asn Thr 
            340                 345                 350         


Arg Leu Tyr Lys Trp Leu Pro Gln Asn Asp Leu Leu Gly His Pro Lys 
        355                 360                 365             


Thr Lys Ala Phe Ile Thr His Gly Gly Thr Asn Gly Ile Tyr Glu Ala 
    370                 375                 380                 


Ile Tyr His Gly Ile Pro Met Val Gly Ile Pro Leu Phe Ala Asp Gln 
385                 390                 395                 400 


His Asp Asn Ile Ala His Met Lys Ala Lys Gly Ala Ala Leu Ser Val 
                405                 410                 415     


Asp Ile Arg Thr Met Ser Ser Arg Asp Leu Leu Asn Ala Leu Lys Ser 
            420                 425                 430         


Val Ile Asn Asp Pro Val Tyr Lys Glu Asn Val Met Lys Leu Ser Arg 
        435                 440                 445             


Ile His His Asp Gln Pro Met Lys Pro Leu Asp Arg Ala Val Phe Trp 
    450                 455                 460                 


Ile Glu Phe Val Met Arg His Lys Gly Ala Lys His Leu Arg Val Ala 
465                 470                 475                 480 


Ala His Asn Leu Thr Trp Ile Gln Tyr His Ser Leu Asp Val Ile Ala 
                485                 490                 495     


Phe Leu Leu Ala Cys Val Ala Thr Val Ile Phe Ile Ile Thr Lys Phe 
            500                 505                 510         


Cys Leu Phe Cys Phe Arg Lys Leu Ala Lys Lys Gly Lys Lys Lys Lys 
        515                 520                 525             


Arg Asp 
    530 


<210>  945
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  945

Met Ser Leu Lys Trp Met Ser Val Phe Leu Leu Met Gln Leu Ser Cys 
1               5                   10                  15      


Tyr Phe Ser Ser Gly Ser Cys Gly Lys Val Leu Val Trp Pro Thr Glu 
            20                  25                  30          


Tyr Ser His Trp Ile Asn Met Lys Thr Ile Leu Glu Glu Leu Val Gln 
        35                  40                  45              


Arg Gly His Glu Val Ile Val Leu Thr Ser Ser Ala Ser Ile Leu Val 
    50                  55                  60                  


Asn Ala Ser Lys Ser Ser Ala Ile Lys Leu Glu Val Tyr Pro Thr Ser 
65                  70                  75                  80  


Leu Thr Lys Asn Asp Leu Glu Asp Phe Phe Met Lys Met Phe Asp Arg 
                85                  90                  95      


Trp Thr Tyr Ser Ile Ser Lys Asn Thr Phe Trp Ser Tyr Phe Ser Gln 
            100                 105                 110         


Leu Gln Glu Leu Cys Trp Glu Tyr Ser Asp Tyr Asn Ile Lys Leu Cys 
        115                 120                 125             


Glu Asp Ala Val Leu Asn Lys Lys Leu Met Arg Lys Leu Gln Glu Ser 
    130                 135                 140                 


Lys Phe Asp Val Leu Leu Ala Asp Ala Val Asn Pro Cys Gly Glu Leu 
145                 150                 155                 160 


Leu Ala Glu Leu Leu Asn Ile Pro Phe Leu Tyr Ser Leu Arg Phe Ser 
                165                 170                 175     


Val Gly Tyr Thr Val Glu Lys Asn Gly Gly Gly Phe Leu Phe Pro Pro 
            180                 185                 190         


Ser Tyr Val Pro Val Val Met Ser Glu Leu Ser Asp Gln Met Ile Phe 
        195                 200                 205             


Met Glu Arg Ile Lys Asn Met Ile Tyr Met Leu Tyr Phe Asp Phe Trp 
    210                 215                 220                 


Phe Gln Ala Tyr Asp Leu Lys Lys Trp Asp Gln Phe Tyr Ser Glu Val 
225                 230                 235                 240 


Leu Gly Arg Pro Thr Thr Leu Phe Glu Thr Met Gly Lys Ala Glu Met 
                245                 250                 255     


Trp Leu Ile Arg Thr Tyr Trp Asp Phe Glu Phe Pro Arg Pro Phe Leu 
            260                 265                 270         


Pro Asn Val Asp Phe Val Gly Gly Leu His Cys Lys Pro Ala Lys Pro 
        275                 280                 285             


Leu Pro Lys Glu Met Glu Glu Phe Val Gln Ser Ser Gly Glu Asn Gly 
    290                 295                 300                 


Ile Val Val Phe Ser Leu Gly Ser Met Ile Ser Asn Met Ser Glu Glu 
305                 310                 315                 320 


Ser Ala Asn Met Ile Ala Ser Ala Leu Ala Gln Ile Pro Gln Lys Val 
                325                 330                 335     


Leu Trp Arg Phe Asp Gly Lys Lys Pro Asn Thr Leu Gly Ser Asn Thr 
            340                 345                 350         


Arg Leu Tyr Lys Trp Leu Pro Gln Asn Asp Leu Leu Gly His Pro Lys 
        355                 360                 365             


Thr Lys Ala Phe Ile Thr His Gly Gly Thr Asn Gly Ile Tyr Glu Ala 
    370                 375                 380                 


Ile Tyr His Gly Ile Pro Met Val Gly Ile Pro Leu Phe Ala Asp Gln 
385                 390                 395                 400 


His Asp Asn Ile Ala His Met Lys Ala Lys Gly Ala Ala Leu Ser Val 
                405                 410                 415     


Asp Ile Arg Thr Met Ser Ser Arg Asp Leu Leu Asn Ala Leu Lys Ser 
            420                 425                 430         


Val Ile Asn Asp Pro Ile Tyr Lys Glu Asn Ile Met Lys Leu Ser Arg 
        435                 440                 445             


Ile His His Asp Gln Pro Val Lys Pro Leu Asp Arg Ala Val Phe Trp 
    450                 455                 460                 


Ile Glu Phe Val Met Arg His Lys Gly Ala Lys His Leu Arg Val Ala 
465                 470                 475                 480 


Ala His Asn Leu Thr Trp Ile Gln Tyr His Ser Leu Asp Val Ile Ala 
                485                 490                 495     


Phe Leu Leu Ala Cys Val Ala Thr Met Ile Phe Met Ile Thr Lys Cys 
            500                 505                 510         


Cys Leu Phe Cys Phe Arg Lys Leu Ala Lys Thr Gly Lys Lys Lys Lys 
        515                 520                 525             


Arg Asp 
    530 


<210>  946
<211>  739
<212>  PRT
<213>  Homo sapiens

<400>  946

Met Pro Gly Lys Met Val Val Ile Leu Gly Ala Ser Asn Ile Leu Trp 
1               5                   10                  15      


Ile Met Phe Ala Ala Ser Gln Ala Phe Lys Ile Glu Thr Thr Pro Glu 
            20                  25                  30          


Ser Arg Tyr Leu Ala Gln Ile Gly Asp Ser Val Ser Leu Thr Cys Ser 
        35                  40                  45              


Thr Thr Gly Cys Glu Ser Pro Phe Phe Ser Trp Arg Thr Gln Ile Asp 
    50                  55                  60                  


Ser Pro Leu Asn Gly Lys Val Thr Asn Glu Gly Thr Thr Ser Thr Leu 
65                  70                  75                  80  


Thr Met Asn Pro Val Ser Phe Gly Asn Glu His Ser Tyr Leu Cys Thr 
                85                  90                  95      


Ala Thr Cys Glu Ser Arg Lys Leu Glu Lys Gly Ile Gln Val Glu Ile 
            100                 105                 110         


Tyr Ser Phe Pro Lys Asp Pro Glu Ile His Leu Ser Gly Pro Leu Glu 
        115                 120                 125             


Ala Gly Lys Pro Ile Thr Val Lys Cys Ser Val Ala Asp Val Tyr Pro 
    130                 135                 140                 


Phe Asp Arg Leu Glu Ile Asp Leu Leu Lys Gly Asp His Leu Met Lys 
145                 150                 155                 160 


Ser Gln Glu Phe Leu Glu Asp Ala Asp Arg Lys Ser Leu Glu Thr Lys 
                165                 170                 175     


Ser Leu Glu Val Thr Phe Thr Pro Val Ile Glu Asp Ile Gly Lys Val 
            180                 185                 190         


Leu Val Cys Arg Ala Lys Leu His Ile Asp Glu Met Asp Ser Val Pro 
        195                 200                 205             


Thr Val Arg Gln Ala Val Lys Glu Leu Gln Val Tyr Ile Ser Pro Lys 
    210                 215                 220                 


Asn Thr Val Ile Ser Val Asn Pro Ser Thr Lys Leu Gln Glu Gly Gly 
225                 230                 235                 240 


Ser Val Thr Met Thr Cys Ser Ser Glu Gly Leu Pro Ala Pro Glu Ile 
                245                 250                 255     


Phe Trp Ser Lys Lys Leu Asp Asn Gly Asn Leu Gln His Leu Ser Gly 
            260                 265                 270         


Asn Ala Thr Leu Thr Leu Ile Ala Met Arg Met Glu Asp Ser Gly Ile 
        275                 280                 285             


Tyr Val Cys Glu Gly Val Asn Leu Ile Gly Lys Asn Arg Lys Glu Val 
    290                 295                 300                 


Glu Leu Ile Val Gln Glu Lys Pro Phe Thr Val Glu Ile Ser Pro Gly 
305                 310                 315                 320 


Pro Arg Ile Ala Ala Gln Ile Gly Asp Ser Val Met Leu Thr Cys Ser 
                325                 330                 335     


Val Met Gly Cys Glu Ser Pro Ser Phe Ser Trp Arg Thr Gln Ile Asp 
            340                 345                 350         


Ser Pro Leu Ser Gly Lys Val Arg Ser Glu Gly Thr Asn Ser Thr Leu 
        355                 360                 365             


Thr Leu Ser Pro Val Ser Phe Glu Asn Glu His Ser Tyr Leu Cys Thr 
    370                 375                 380                 


Val Thr Cys Gly His Lys Lys Leu Glu Lys Gly Ile Gln Val Glu Leu 
385                 390                 395                 400 


Tyr Ser Phe Pro Arg Asp Pro Glu Ile Glu Met Ser Gly Gly Leu Val 
                405                 410                 415     


Asn Gly Ser Ser Val Thr Val Ser Cys Lys Val Pro Ser Val Tyr Pro 
            420                 425                 430         


Leu Asp Arg Leu Glu Ile Glu Leu Leu Lys Gly Glu Thr Ile Leu Glu 
        435                 440                 445             


Asn Ile Glu Phe Leu Glu Asp Thr Asp Met Lys Ser Leu Glu Asn Lys 
    450                 455                 460                 


Ser Leu Glu Met Thr Phe Ile Pro Thr Ile Glu Asp Thr Gly Lys Ala 
465                 470                 475                 480 


Leu Val Cys Gln Ala Lys Leu His Ile Asp Asp Met Glu Phe Glu Pro 
                485                 490                 495     


Lys Gln Arg Gln Ser Thr Gln Thr Leu Tyr Val Asn Val Ala Pro Arg 
            500                 505                 510         


Asp Thr Thr Val Leu Val Ser Pro Ser Ser Ile Leu Glu Glu Gly Ser 
        515                 520                 525             


Ser Val Asn Met Thr Cys Leu Ser Gln Gly Phe Pro Ala Pro Lys Ile 
    530                 535                 540                 


Leu Trp Ser Arg Gln Leu Pro Asn Gly Glu Leu Gln Pro Leu Ser Glu 
545                 550                 555                 560 


Asn Ala Thr Leu Thr Leu Ile Ser Thr Lys Met Glu Asp Ser Gly Val 
                565                 570                 575     


Tyr Leu Cys Glu Gly Ile Asn Gln Ala Gly Arg Ser Arg Lys Glu Val 
            580                 585                 590         


Glu Leu Ile Ile Gln Val Thr Pro Lys Asp Ile Lys Leu Thr Ala Phe 
        595                 600                 605             


Pro Ser Glu Ser Val Lys Glu Gly Asp Thr Val Ile Ile Ser Cys Thr 
    610                 615                 620                 


Cys Gly Asn Val Pro Glu Thr Trp Ile Ile Leu Lys Lys Lys Ala Glu 
625                 630                 635                 640 


Thr Gly Asp Thr Val Leu Lys Ser Ile Asp Gly Ala Tyr Thr Ile Arg 
                645                 650                 655     


Lys Ala Gln Leu Lys Asp Ala Gly Val Tyr Glu Cys Glu Ser Lys Asn 
            660                 665                 670         


Lys Val Gly Ser Gln Leu Arg Ser Leu Thr Leu Asp Val Gln Gly Arg 
        675                 680                 685             


Glu Asn Asn Lys Asp Tyr Phe Ser Pro Glu Leu Leu Val Leu Tyr Phe 
    690                 695                 700                 


Ala Ser Ser Leu Ile Ile Pro Ala Ile Gly Met Ile Ile Tyr Phe Ala 
705                 710                 715                 720 


Arg Lys Ala Asn Met Lys Gly Ser Tyr Ser Leu Val Glu Ala Gln Lys 
                725                 730                 735     


Ser Lys Val 
            


<210>  947
<211>  714
<212>  PRT
<213>  Homo sapiens

<400>  947

Met Gly Leu Pro Glu Glu Arg Val Arg Ser Gly Ser Gly Ser Arg Gly 
1               5                   10                  15      


Gln Glu Glu Ala Gly Ala Gly Gly Arg Ala Arg Ser Trp Ser Pro Pro 
            20                  25                  30          


Pro Glu Val Ser Arg Ser Ala His Val Pro Ser Leu Gln Arg Tyr Arg 
        35                  40                  45              


Glu Leu His Arg Arg Ser Val Glu Glu Pro Arg Glu Phe Trp Gly Asp 
    50                  55                  60                  


Ile Ala Lys Glu Phe Tyr Trp Lys Thr Pro Cys Pro Gly Pro Phe Leu 
65                  70                  75                  80  


Arg Tyr Asn Phe Asp Val Thr Lys Gly Lys Ile Phe Ile Glu Trp Met 
                85                  90                  95      


Lys Gly Ala Thr Thr Asn Ile Cys Tyr Asn Val Leu Asp Arg Asn Val 
            100                 105                 110         


His Glu Lys Lys Leu Gly Asp Lys Val Ala Phe Tyr Trp Glu Gly Asn 
        115                 120                 125             


Glu Pro Gly Glu Thr Thr Gln Ile Thr Tyr His Gln Leu Leu Val Gln 
    130                 135                 140                 


Val Cys Gln Phe Ser Asn Val Leu Arg Lys Gln Gly Ile Gln Lys Gly 
145                 150                 155                 160 


Asp Arg Val Ala Ile Tyr Met Pro Met Ile Pro Glu Leu Val Val Ala 
                165                 170                 175     


Met Leu Ala Cys Ala Arg Ile Gly Ala Leu His Ser Ile Val Phe Ala 
            180                 185                 190         


Gly Phe Ser Ser Glu Ser Leu Cys Glu Arg Ile Leu Asp Ser Ser Cys 
        195                 200                 205             


Ser Leu Leu Ile Thr Thr Asp Ala Phe Tyr Arg Gly Glu Lys Leu Val 
    210                 215                 220                 


Asn Leu Lys Glu Leu Ala Asp Glu Ala Leu Gln Lys Cys Gln Glu Lys 
225                 230                 235                 240 


Gly Phe Pro Val Arg Cys Cys Ile Val Val Lys His Leu Gly Arg Ala 
                245                 250                 255     


Glu Leu Gly Met Gly Asp Ser Thr Ser Gln Ser Pro Pro Ile Lys Arg 
            260                 265                 270         


Ser Cys Pro Asp Val Gln Gly Lys Leu Lys Glu Lys Ser Lys Arg Val 
        275                 280                 285             


Gln Pro Gln Ile Ser Trp Asn Gln Gly Ile Asp Leu Trp Trp His Glu 
    290                 295                 300                 


Leu Met Gln Glu Ala Gly Asp Glu Cys Glu Pro Glu Trp Cys Asp Ala 
305                 310                 315                 320 


Glu Asp Pro Leu Phe Ile Leu Tyr Thr Ser Gly Ser Thr Gly Lys Pro 
                325                 330                 335     


Lys Gly Val Val His Thr Val Gly Gly Tyr Met Leu Tyr Val Ala Thr 
            340                 345                 350         


Thr Phe Lys Tyr Val Phe Asp Phe His Ala Glu Asp Val Phe Trp Cys 
        355                 360                 365             


Thr Ala Asp Ile Gly Trp Ile Thr Gly His Ser Tyr Val Thr Tyr Gly 
    370                 375                 380                 


Pro Leu Ala Asn Gly Ala Thr Ser Val Leu Phe Glu Gly Ile Pro Thr 
385                 390                 395                 400 


Tyr Pro Asp Val Asn Arg Leu Trp Ser Ile Val Asp Lys Tyr Lys Val 
                405                 410                 415     


Thr Lys Phe Tyr Thr Ala Pro Thr Ala Ile Arg Leu Leu Met Lys Phe 
            420                 425                 430         


Gly Asp Glu Pro Val Thr Lys His Ser Arg Ala Ser Leu Gln Val Leu 
        435                 440                 445             


Gly Thr Val Gly Glu Pro Ile Asn Pro Glu Ala Trp Leu Trp Tyr His 
    450                 455                 460                 


Arg Val Val Gly Ala Gln Arg Cys Pro Ile Val Asp Thr Phe Trp Gln 
465                 470                 475                 480 


Thr Glu Thr Gly Gly His Met Leu Thr Pro Leu Pro Gly Ala Thr Pro 
                485                 490                 495     


Met Lys Pro Gly Ser Ala Thr Phe Pro Phe Phe Gly Val Ala Pro Ala 
            500                 505                 510         


Ile Leu Asn Glu Ser Gly Glu Glu Leu Glu Gly Glu Ala Glu Gly Tyr 
        515                 520                 525             


Leu Val Phe Lys Gln Pro Trp Pro Gly Ile Met Arg Thr Val Tyr Gly 
    530                 535                 540                 


Asn His Glu Arg Phe Glu Thr Thr Tyr Phe Lys Lys Phe Pro Gly Tyr 
545                 550                 555                 560 


Tyr Val Thr Gly Asp Gly Cys Gln Arg Asp Gln Asp Gly Tyr Tyr Trp 
                565                 570                 575     


Ile Thr Gly Arg Ile Asp Asp Met Leu Asn Val Ser Gly His Leu Leu 
            580                 585                 590         


Ser Thr Ala Glu Val Glu Ser Ala Leu Val Glu His Glu Ala Val Ala 
        595                 600                 605             


Glu Ala Ala Val Val Gly His Pro His Pro Val Lys Gly Glu Cys Leu 
    610                 615                 620                 


Tyr Cys Phe Val Thr Leu Cys Asp Gly His Thr Phe Ser Pro Lys Leu 
625                 630                 635                 640 


Thr Glu Glu Leu Lys Lys Gln Ile Arg Glu Lys Ile Gly Pro Ile Ala 
                645                 650                 655     


Thr Pro Asp Tyr Ile Gln Asn Ala Pro Gly Leu Pro Lys Thr Arg Ser 
            660                 665                 670         


Gly Lys Ile Met Arg Arg Val Leu Arg Lys Ile Ala Gln Asn Asp His 
        675                 680                 685             


Asp Leu Gly Asp Met Ser Thr Val Ala Asp Pro Ser Val Ile Ser His 
    690                 695                 700                 


Leu Phe Ser His Arg Cys Leu Thr Ile Gln 
705                 710                 


<210>  948
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  948

Met Ile Ser Arg His Leu Gln Asn Asn Leu Met Ser Val Asp Pro Ala 
1               5                   10                  15      


Ser Ser Gln Ala Met Glu Leu Ser Asp Val Thr Leu Ile Glu Gly Val 
            20                  25                  30          


Gly Asn Glu Val Met Val Val Ala Gly Val Val Val Leu Ile Leu Ala 
        35                  40                  45              


Leu Val Leu Ala Trp Leu Ser Thr Tyr Val Ala Asp Ser Gly Ser Asn 
    50                  55                  60                  


Gln Leu Leu Gly Ala Ile Val Ser Ala Gly Asp Thr Ser Val Leu His 
65                  70                  75                  80  


Leu Gly His Val Asp His Leu Val Ala Gly Gln Gly Asn Pro Glu Pro 
                85                  90                  95      


Thr Glu Leu Pro His Pro Ser Glu Gly Asn Asp Glu Lys Ala Glu Glu 
            100                 105                 110         


Ala Gly Glu Gly Arg Gly Asp Ser Thr Gly Glu Ala Gly Ala Gly Gly 
        115                 120                 125             


Gly Val Glu Pro Ser Leu Glu His Leu Leu Asp Ile Gln Gly Leu Pro 
    130                 135                 140                 


Lys Arg Gln Ala Gly Ala Gly Ser Ser Ser Pro Glu Ala Pro Leu Arg 
145                 150                 155                 160 


Ser Glu Asp Ser Thr Cys Leu Pro Pro Ser Pro Gly Leu Ile Thr Val 
                165                 170                 175     


Arg Leu Lys Phe Leu Asn Asp Thr Glu Glu Leu Ala Val Ala Arg Pro 
            180                 185                 190         


Glu Asp Thr Val Gly Ala Leu Lys Ser Lys Tyr Phe Pro Gly Gln Glu 
        195                 200                 205             


Ser Gln Met Lys Leu Ile Tyr Gln Gly Arg Leu Leu Gln Asp Pro Ala 
    210                 215                 220                 


Arg Thr Leu Arg Ser Leu Asn Ile Thr Asp Asn Cys Val Ile His Cys 
225                 230                 235                 240 


His Arg Ser Pro Pro Gly Ser Ala Val Pro Gly Pro Ser Ala Ser Leu 
                245                 250                 255     


Ala Pro Ser Ala Thr Glu Pro Pro Ser Leu Gly Val Asn Val Gly Ser 
            260                 265                 270         


Leu Met Val Pro Val Phe Val Val Leu Leu Gly Val Val Trp Tyr Phe 
        275                 280                 285             


Arg Ile Asn Tyr Arg Gln Phe Phe Thr Ala Pro Ala Thr Val Ser Leu 
    290                 295                 300                 


Val Gly Val Thr Val Phe Phe Ser Phe Leu Val Phe Gly Met Tyr Gly 
305                 310                 315                 320 


Arg 
    


<210>  949
<211>  761
<212>  PRT
<213>  Homo sapiens

<400>  949

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Thr Leu Asp Gly His Met Val Val Arg Ser His Ala Arg Val Ser 
        355                 360                 365             


Ser Leu Thr Leu Lys Ser Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile 
    370                 375                 380                 


Cys Thr Ala Ser Asn Thr Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu 
385                 390                 395                 400 


Glu Val Gln Tyr Ala Pro Lys Leu Gln Gly Pro Val Ala Val Tyr Thr 
                405                 410                 415     


Trp Glu Gly Asn Gln Val Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro 
            420                 425                 430         


Ser Ala Thr Ile Ser Trp Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser 
        435                 440                 445             


Asn Tyr Ser Asn Ile Lys Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu 
    450                 455                 460                 


Glu Val Thr Pro Asp Ser Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr 
465                 470                 475                 480 


Ala Val Asn Arg Ile Gly Gln Glu Ser Leu Glu Phe Ile Leu Val Gln 
                485                 490                 495     


Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser 
            500                 505                 510         


Ser Thr Ala Gln Val Gln Phe Asp Glu Pro Glu Ala Thr Gly Gly Val 
        515                 520                 525             


Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg Ala Val Gly Glu Glu Val 
    530                 535                 540                 


Trp His Ser Lys Trp Tyr Asp Ala Lys Glu Ala Ser Met Glu Gly Ile 
545                 550                 555                 560 


Val Thr Ile Val Gly Leu Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu 
                565                 570                 575     


Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu 
            580                 585                 590         


Phe Lys Thr Gln Pro Val His Ser Pro Pro Pro Pro Ala Ser Ala Ser 
        595                 600                 605             


Ser Ser Thr Pro Val Pro Leu Ser Pro Pro Asp Thr Thr Trp Pro Leu 
    610                 615                 620                 


Pro Ala Leu Ala Thr Thr Glu Pro Ala Lys Gly Glu Pro Ser Ala Pro 
625                 630                 635                 640 


Lys Leu Glu Gly Gln Met Gly Glu Asp Gly Asn Ser Ile Lys Val Asn 
                645                 650                 655     


Leu Ile Lys Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu Val 
            660                 665                 670         


Arg Tyr Arg Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu Pro 
        675                 680                 685             


Ser Gly Ser Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala Glu 
    690                 695                 700                 


Tyr Glu Val Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys Ala 
705                 710                 715                 720 


Ala His Phe Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro Ala 
                725                 730                 735     


Thr Leu Gly Gly Asn Ser Ala Ser Tyr Thr Phe Val Ser Leu Leu Phe 
            740                 745                 750         


Ser Ala Val Thr Leu Leu Leu Leu Cys 
        755                 760     


<210>  950
<211>  991
<212>  PRT
<213>  Homo sapiens

<400>  950

Met Ser Ala Val Gly Leu Val Leu Leu Val Leu Ala Leu Arg Leu Arg 
1               5                   10                  15      


Ala Thr Thr Val Lys Pro Glu Glu Gly Ser Phe Cys Ser Asn Ser Gln 
            20                  25                  30          


Val Ala Phe Arg Asp Ala Cys Tyr Glu Phe Val Pro Leu Gly Arg Thr 
        35                  40                  45              


Phe Arg Asp Ala Gln Ser Trp Cys Glu Gly Gln Gly Gly His Leu Val 
    50                  55                  60                  


Phe Ile Gln Asp Glu Gly Thr Gln Trp Phe Leu Gln Lys His Ile Ser 
65                  70                  75                  80  


Gln Asp Arg Glu Trp Trp Ile Gly Leu Thr Trp Asn Leu Ala Arg Asn 
                85                  90                  95      


Gly Thr Thr Glu Gly Pro Gly Thr Trp Leu Asp Thr Ser Asn Val Thr 
            100                 105                 110         


Tyr Ser Asn Trp His Gly Gly Gln Ala Ala Ala Ala Pro Asp Thr Cys 
        115                 120                 125             


Gly His Ile Gly Arg Gly Pro Ser Ser Glu Trp Val Thr Ser Asp Cys 
    130                 135                 140                 


Ala Gln Thr Phe Ala Phe Met Cys Glu Phe Arg Val Gly Gln Ser Leu 
145                 150                 155                 160 


Ala Cys Glu Gly Leu Asn Ala Thr Val His Cys Gly Leu Gly Gln Val 
                165                 170                 175     


Ile Gln Val Gln Asp Ala Val Tyr Gly Arg Gln Asn Pro His Phe Cys 
            180                 185                 190         


Thr Gln Asp Ala Gly Arg Pro Ser Asp Leu Glu Gln Gly Cys Ser Trp 
        195                 200                 205             


Ala Asn Val Lys Glu Glu Val Ala Gly Gln Cys Gln Glu Leu Gln Ser 
    210                 215                 220                 


Cys Gln Val Ala Ala Asp Glu Thr Tyr Phe Gly Asn Leu Cys Pro Thr 
225                 230                 235                 240 


Gln Gly Ser Tyr Leu Trp Val Gln Tyr Gln Cys Arg Glu Ala Leu Gln 
                245                 250                 255     


Leu Met Val Ser Ser Glu Ser Phe Ile Phe Asp Asn Val Thr Ile Ser 
            260                 265                 270         


Leu Thr Trp Leu Leu Ser Pro Tyr Ile Gly Asn Leu Ser Cys Ile Ile 
        275                 280                 285             


Ser Thr Gly Asp Ser His Thr Phe Asp Pro Tyr Asn Pro Pro Ser Val 
    290                 295                 300                 


Ser Ser Asn Val Thr His Gln Phe Thr Ser Pro Gly Glu Phe Thr Val 
305                 310                 315                 320 


Phe Ala Glu Cys Thr Thr Ser Glu Trp His Val Thr Ala Gln Arg Gln 
                325                 330                 335     


Val Thr Val Arg Asp Lys Met Glu Thr Leu Ser Val Thr Ala Cys Ser 
            340                 345                 350         


Gly Leu Ser Gln Ser Gly Ala Gly Pro Leu Cys Gln Ala Val Phe Gly 
        355                 360                 365             


Asp Pro Leu Trp Ile Gln Val Glu Leu Asp Gly Gly Thr Gly Val Thr 
    370                 375                 380                 


Tyr Thr Val Leu Leu Gly Asp Ile Thr Leu Ala Glu Ser Thr Thr Gln 
385                 390                 395                 400 


Lys Gly Ser Leu Pro Tyr Asn Leu Ile Leu Asp Arg Glu Thr Gln Lys 
                405                 410                 415     


Leu Met Gly Pro Gly Arg His Arg Leu Glu Ile Gln Ala Thr Gly Asn 
            420                 425                 430         


Thr Thr Thr Ser Thr Ile Ser Arg Asn Ile Thr Val His Leu Val Glu 
        435                 440                 445             


Leu Leu Ser Gly Leu Gln Ala Ser Trp Ala Ser Asp His Leu Glu Leu 
    450                 455                 460                 


Gly Gln Asp Leu Leu Ile Thr Ile Ser Leu Ala Gln Gly Thr Pro Glu 
465                 470                 475                 480 


Glu Leu Thr Phe Glu Val Ala Gly Leu Asn Ala Thr Phe Ser His Glu 
                485                 490                 495     


Gln Val Ser Phe Gly Glu Pro Phe Gly Ile Cys Arg Leu Ala Val Pro 
            500                 505                 510         


Val Glu Gly Thr Phe Leu Val Thr Met Leu Val Arg Asn Ala Phe Ser 
        515                 520                 525             


Asn Leu Ser Leu Glu Ile Gly Asn Ile Thr Ile Thr Ala Pro Ser Gly 
    530                 535                 540                 


Leu Gln Glu Pro Ser Gly Met Asn Ala Glu Gly Lys Ser Lys Asp Lys 
545                 550                 555                 560 


Gly Asp Met Glu Val Tyr Ile Gln Pro Gly Pro Tyr Val Asp Pro Phe 
                565                 570                 575     


Thr Thr Val Thr Leu Gly Trp Pro Asp Asn Asp Lys Glu Leu Arg Phe 
            580                 585                 590         


Gln Trp Ser Cys Gly Ser Cys Trp Ala Leu Trp Ser Ser Cys Val Glu 
        595                 600                 605             


Arg Gln Leu Leu Arg Thr Asp Gln Arg Glu Leu Val Val Pro Ala Ser 
    610                 615                 620                 


Cys Leu Pro Pro Pro Asp Ser Ala Val Thr Leu Arg Leu Ala Val Leu 
625                 630                 635                 640 


Arg Gly Gln Glu Leu Glu Asn Arg Ala Glu Gln Cys Leu Tyr Val Ser 
                645                 650                 655     


Ala Pro Trp Glu Leu Arg Pro Arg Val Ser Cys Glu Arg Asn Cys Arg 
            660                 665                 670         


Pro Val Asn Ala Ser Lys Asp Ile Leu Leu Arg Val Thr Met Gly Glu 
        675                 680                 685             


Asp Ser Pro Val Ala Met Phe Ser Trp Tyr Leu Asp Asn Thr Pro Thr 
    690                 695                 700                 


Glu Gln Ala Glu Pro Leu Leu Asp Ala Cys Arg Leu Arg Gly Phe Trp 
705                 710                 715                 720 


Pro Arg Ser Leu Thr Leu Leu Gln Ser Asn Thr Ser Thr Leu Leu Leu 
                725                 730                 735     


Asn Ser Ser Phe Leu Gln Ser Arg Gly Glu Val Ile Arg Ile Arg Ala 
            740                 745                 750         


Thr Ala Leu Thr Arg His Ala Tyr Gly Glu Asp Thr Tyr Val Ile Ser 
        755                 760                 765             


Thr Val Pro Pro Arg Glu Val Pro Ala Cys Thr Ile Ala Pro Glu Glu 
    770                 775                 780                 


Gly Thr Val Leu Thr Ser Phe Ala Ile Phe Cys Asn Ala Ser Thr Ala 
785                 790                 795                 800 


Leu Gly Pro Leu Glu Phe Cys Phe Cys Leu Glu Ser Gly Ser Cys Leu 
                805                 810                 815     


His Cys Gly Pro Glu Pro Ala Leu Pro Ser Val Tyr Leu Pro Leu Gly 
            820                 825                 830         


Glu Glu Asn Asn Asp Phe Val Leu Thr Val Val Ile Ser Ala Thr Asn 
        835                 840                 845             


Arg Ala Gly Asp Thr Gln Gln Thr Gln Ala Met Ala Lys Val Ala Leu 
    850                 855                 860                 


Gly Asp Thr Cys Val Glu Asp Val Ala Phe Gln Ala Ala Val Ser Glu 
865                 870                 875                 880 


Lys Ile Pro Thr Ala Leu Gln Gly Glu Gly Gly Pro Glu Gln Leu Leu 
                885                 890                 895     


Gln Leu Ala Lys Ala Val Ser Ser Met Leu Asn Gln Glu His Glu Ser 
            900                 905                 910         


Gln Gly Ser Gly Gln Ser Leu Ser Ile Asp Val Arg Gln Lys Val Arg 
        915                 920                 925             


Glu His Val Leu Gly Ser Leu Ser Ala Val Thr Thr Gly Leu Glu Asp 
    930                 935                 940                 


Val Gln Arg Val Gln Glu Leu Ala Glu Val Leu Arg Glu Val Thr Cys 
945                 950                 955                 960 


Arg Ser Lys Glu Leu Thr Pro Ser Ala Gln Gly Ser Cys Met Gly Asp 
                965                 970                 975     


Ser Trp Glu Gly Ala Pro Pro Ala Ala His Val Ser His Ala Arg 
            980                 985                 990     


<210>  951
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  951

Met Glu Ala Arg Glu Pro Gly Arg Pro Thr Pro Thr Tyr His Leu Val 
1               5                   10                  15      


Pro Asn Thr Ser Gln Ser Gln Val Glu Glu Asp Val Ser Ser Pro Pro 
            20                  25                  30          


Gln Arg Ser Ser Glu Thr Met Gln Leu Lys Lys Glu Ile Ser Leu Leu 
        35                  40                  45              


Asn Gly Val Ser Leu Val Val Gly Asn Met Ile Gly Ser Gly Ile Phe 
    50                  55                  60                  


Val Ser Pro Lys Gly Val Leu Val His Thr Ala Ser Tyr Gly Met Ser 
65                  70                  75                  80  


Leu Ile Val Trp Ala Ile Gly Gly Leu Phe Ser Val Val Gly Ala Leu 
                85                  90                  95      


Cys Tyr Ala Glu Leu Gly Thr Thr Ile Thr Lys Ser Gly Ala Ser Tyr 
            100                 105                 110         


Ala Tyr Ile Leu Glu Ala Phe Gly Gly Phe Ile Ala Phe Ile Arg Leu 
        115                 120                 125             


Trp Val Ser Leu Leu Val Val Glu Pro Thr Gly Gln Ala Ile Ile Ala 
    130                 135                 140                 


Ile Thr Phe Ala Asn Tyr Ile Ile Gln Pro Ser Phe Pro Ser Cys Asp 
145                 150                 155                 160 


Pro Pro Tyr Leu Ala Cys Arg Leu Leu Ala Ala Ala Cys Ile Cys Leu 
                165                 170                 175     


Leu Thr Phe Val Asn Cys Ala Tyr Val Lys Trp Gly Thr Arg Val Gln 
            180                 185                 190         


Asp Thr Phe Thr Tyr Ala Lys Val Val Ala Leu Ile Ala Ile Ile Val 
        195                 200                 205             


Met Gly Leu Val Lys Leu Cys Gln Gly His Ser Glu His Phe Gln Asp 
    210                 215                 220                 


Ala Phe Glu Gly Ser Ser Trp Asp Met Gly Asn Leu Ser Leu Ala Leu 
225                 230                 235                 240 


Tyr Ser Ala Leu Phe Ser Tyr Ser Gly Trp Asp Thr Leu Asn Phe Val 
                245                 250                 255     


Thr Glu Glu Ile Lys Asn Pro Glu Arg Asn Leu Pro Leu Ala Ile Gly 
            260                 265                 270         


Ile Ser Met Pro Ile Val Thr Leu Ile Tyr Ile Leu Thr Asn Val Ala 
        275                 280                 285             


Tyr Tyr Thr Val Leu Asn Ile Ser Asp Val Leu Ser Ser Asp Ala Val 
    290                 295                 300                 


Ala Val Thr Phe Ala Asp Gln Thr Phe Gly Met Phe Ser Trp Thr Ile 
305                 310                 315                 320 


Pro Ile Ala Val Ala Leu Ser Cys Phe Gly Gly Leu Asn Ala Ser Ile 
                325                 330                 335     


Phe Ala Ser Ser Arg Leu Phe Phe Val Gly Ser Arg Glu Gly His Leu 
            340                 345                 350         


Pro Asp Leu Leu Ser Met Ile His Ile Glu Arg Phe Thr Pro Ile Pro 
        355                 360                 365             


Ala Leu Leu Phe Asn Cys Thr Met Ala Leu Ile Tyr Leu Ile Val Glu 
    370                 375                 380                 


Asp Val Phe Gln Leu Ile Asn Tyr Phe Ser Phe Ser Tyr Trp Phe Phe 
385                 390                 395                 400 


Val Gly Leu Ser Val Val Gly Gln Leu Tyr Leu Arg Trp Lys Glu Pro 
                405                 410                 415     


Lys Arg Pro Arg Pro Leu Lys Leu Ser Val Phe Phe Pro Ile Val Phe 
            420                 425                 430         


Cys Ile Cys Ser Val Phe Leu Val Ile Val Pro Leu Phe Thr Asp Thr 
        435                 440                 445             


Ile Asn Ser Leu Ile Gly Ile Gly Ile Ala Leu Ser Gly Val Pro Phe 
    450                 455                 460                 


Tyr Phe Met Gly Val Tyr Leu Pro Glu Ser Arg Arg Pro Leu Phe Ile 
465                 470                 475                 480 


Arg Asn Val Leu Ala Ala Ile Thr Arg Gly Thr Gln Gln Leu Cys Phe 
                485                 490                 495     


Cys Val Leu Thr Glu Leu Asp Val Ala Glu Glu Lys Lys Asp Glu Arg 
            500                 505                 510         


Lys Thr Asp 
        515 


<210>  952
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  952

Met Ser Arg Glu Gly Ala Gly Ala Ala Leu Val Ala Glu Val Ile Lys 
1               5                   10                  15      


Asp Arg Leu Cys Phe Ala Ile Leu Tyr Ser Arg Pro Lys Ser Ala Ser 
            20                  25                  30          


Asn Val His Tyr Phe Ser Ile Asp Asn Glu Leu Glu Tyr Glu Asn Phe 
        35                  40                  45              


Tyr Ala Asp Phe Gly Pro Leu Asn Leu Ala Met Val Tyr Arg Tyr Cys 
    50                  55                  60                  


Cys Lys Ile Asn Lys Lys Leu Lys Ser Ile Thr Met Leu Arg Lys Lys 
65                  70                  75                  80  


Ile Val His Phe Thr Gly Ser Asp Gln Arg Lys Gln Ala Asn Ala Ala 
                85                  90                  95      


Phe Leu Val Gly Cys Tyr Met Val Ile Tyr Leu Gly Arg Thr Pro Glu 
            100                 105                 110         


Glu Ala Tyr Arg Ile Leu Ile Phe Gly Glu Thr Ser Tyr Ile Pro Phe 
        115                 120                 125             


Arg Asp Ala Ala Tyr Gly Ser Cys Asn Phe Tyr Ile Thr Leu Leu Asp 
    130                 135                 140                 


Cys Phe His Ala Val Lys Lys Ala Met Gln Tyr Gly Phe Leu Asn Phe 
145                 150                 155                 160 


Asn Ser Phe Asn Leu Asp Glu Tyr Glu His Tyr Glu Lys Ala Glu Asn 
                165                 170                 175     


Gly Asp Leu Asn Trp Ile Ile Pro Asp Arg Phe Ile Ala Phe Cys Gly 
            180                 185                 190         


Pro His Ser Arg Ala Arg Leu Glu Ser Gly Tyr His Gln His Ser Pro 
        195                 200                 205             


Glu Thr Tyr Ile Gln Tyr Phe Lys Asn His Asn Val Thr Thr Ile Ile 
    210                 215                 220                 


Arg Leu Asn Lys Arg Met Tyr Asp Ala Lys Arg Phe Thr Asp Ala Gly 
225                 230                 235                 240 


Phe Asp His His Asp Leu Phe Phe Ala Asp Gly Ser Thr Pro Thr Asp 
                245                 250                 255     


Ala Ile Val Lys Glu Phe Leu Asp Ile Cys Glu Asn Ala Glu Gly Ala 
            260                 265                 270         


Ile Ala Val His Cys Lys Ala Gly Leu Gly Arg Thr Gly Thr Leu Ile 
        275                 280                 285             


Ala Cys Tyr Ile Met Lys His Tyr Arg Met Thr Ala Ala Glu Thr Ile 
    290                 295                 300                 


Ala Trp Val Arg Ile Cys Arg Pro Gly Ser Val Ile Gly Pro Gln Gln 
305                 310                 315                 320 


Gln Phe Leu Val Met Lys Gln Thr Asn Leu Trp Leu Glu Gly Asp Tyr 
                325                 330                 335     


Phe Arg Gln Lys Leu Lys Gly Gln Glu Asn Gly Gln His Arg Ala Ala 
            340                 345                 350         


Phe Ser Lys Leu Leu Ser Gly Val Asp Asp Ile Ser Ile Asn Gly Val 
        355                 360                 365             


Glu Asn Gln Asp Gln Gln Glu Pro Glu Pro Tyr Ser Asp Asp Asp Glu 
    370                 375                 380                 


Ile Asn Gly Val Thr Gln Gly Asp Arg Leu Arg Ala Leu Lys Ser Arg 
385                 390                 395                 400 


Arg Gln Ser Lys Thr Asn Ala Ile Pro Leu Thr Val Ile Leu Gln Ser 
                405                 410                 415     


Ser Val Gln Ser Cys Lys Thr Ser Glu Pro Asn Ile Ser Gly Ser Ala 
            420                 425                 430         


Gly Ile Thr Lys Arg Thr Thr Arg Ser Ala Ser Arg Lys Ser Ser Val 
        435                 440                 445             


Lys Ser Leu Ser Ile Ser Arg Thr Lys Thr Val Leu Arg 
    450                 455                 460     


<210>  953
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  953

Met Thr Pro Asn Ser Thr Gly Glu Val Pro Ser Pro Ile Pro Lys Gly 
1               5                   10                  15      


Ala Leu Gly Leu Ser Leu Ala Leu Ala Ser Leu Ile Ile Thr Ala Asn 
            20                  25                  30          


Leu Leu Leu Ala Leu Gly Ile Ala Trp Asp Arg Arg Leu Arg Ser Pro 
        35                  40                  45              


Pro Ala Gly Cys Phe Phe Leu Ser Leu Leu Leu Ala Gly Leu Leu Thr 
    50                  55                  60                  


Gly Leu Ala Leu Pro Thr Leu Pro Gly Leu Trp Asn Gln Ser Arg Arg 
65                  70                  75                  80  


Gly Tyr Trp Ser Cys Leu Leu Val Tyr Leu Ala Pro Asn Phe Ser Phe 
                85                  90                  95      


Leu Ser Leu Leu Ala Asn Leu Leu Leu Val His Gly Glu Arg Tyr Met 
            100                 105                 110         


Ala Val Leu Arg Pro Leu Gln Pro Pro Gly Ser Ile Arg Leu Ala Leu 
        115                 120                 125             


Leu Leu Thr Trp Ala Gly Pro Leu Leu Phe Ala Ser Leu Pro Ala Leu 
    130                 135                 140                 


Gly Trp Asn His Trp Thr Pro Gly Ala Asn Cys Ser Ser Gln Ala Ile 
145                 150                 155                 160 


Phe Pro Ala Pro Tyr Leu Tyr Leu Glu Val Tyr Gly Leu Leu Leu Pro 
                165                 170                 175     


Ala Val Gly Ala Ala Ala Phe Leu Ser Val Arg Val Leu Ala Thr Ala 
            180                 185                 190         


His Arg Gln Leu Gln Asp Ile Cys Arg Leu Glu Arg Ala Val Cys Arg 
        195                 200                 205             


Asp Glu Pro Ser Ala Leu Ala Arg Ala Leu Thr Trp Arg Gln Ala Arg 
    210                 215                 220                 


Ala Gln Ala Gly Ala Met Leu Leu Phe Gly Leu Cys Trp Gly Pro Tyr 
225                 230                 235                 240 


Val Ala Thr Leu Leu Leu Ser Val Leu Ala Tyr Glu Gln Arg Pro Pro 
                245                 250                 255     


Leu Gly Pro Gly Thr Leu Leu Ser Leu Leu Ser Leu Gly Ser Ala Ser 
            260                 265                 270         


Ala Ala Ala Val Pro Val Ala Met Gly Leu Gly Asp Gln Arg Tyr Thr 
        275                 280                 285             


Ala Pro Trp Arg Ala Ala Ala Gln Arg Cys Leu Gln Gly Leu Trp Gly 
    290                 295                 300                 


Arg Ala Ser Arg Asp Ser Pro Gly Pro Ser Ile Ala Tyr His Pro Ser 
305                 310                 315                 320 


Ser Gln Ser Ser Val Asp Leu Asp Leu Asn 
                325                 330 


<210>  954
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  954

Met Thr Pro Asn Ser Thr Gly Glu Val Pro Ser Pro Ile Pro Lys Gly 
1               5                   10                  15      


Ala Leu Gly Leu Ser Leu Ala Leu Ala Ser Leu Ile Ile Thr Ala Asn 
            20                  25                  30          


Leu Leu Leu Ala Leu Gly Ile Ala Trp Asp Arg Arg Leu Arg Ser Pro 
        35                  40                  45              


Pro Ala Gly Cys Phe Phe Leu Ser Leu Leu Leu Ala Gly Leu Leu Thr 
    50                  55                  60                  


Gly Leu Ala Leu Pro Thr Leu Pro Gly Leu Trp Asn Gln Ser Arg Arg 
65                  70                  75                  80  


Gly Tyr Trp Ser Cys Leu Leu Val Tyr Leu Ala Pro Asn Phe Ser Phe 
                85                  90                  95      


Leu Ser Leu Leu Ala Asn Leu Leu Leu Val His Gly Glu Arg Tyr Met 
            100                 105                 110         


Ala Val Leu Arg Pro Leu Gln Pro Pro Gly Ser Ile Arg Leu Ala Leu 
        115                 120                 125             


Leu Leu Thr Trp Ala Gly Pro Leu Leu Phe Ala Ser Leu Pro Ala Leu 
    130                 135                 140                 


Gly Trp Asn His Trp Thr Pro Gly Ala Asn Cys Ser Ser Gln Ala Ile 
145                 150                 155                 160 


Phe Pro Ala Pro Tyr Leu Tyr Leu Glu Val Tyr Gly Leu Leu Leu Pro 
                165                 170                 175     


Ala Val Gly Ala Ala Ala Phe Leu Ser Val Arg Val Leu Ala Thr Ala 
            180                 185                 190         


His Arg Gln Leu Gln Asp Ile Cys Arg Leu Glu Arg Ala Val Cys Arg 
        195                 200                 205             


Asp Glu Pro Ser Ala Leu Ala Arg Ala Leu Thr Trp Arg Gln Ala Arg 
    210                 215                 220                 


Ala Gln Ala Gly Ala Met Leu Leu Phe Gly Leu Cys Trp Gly Pro Tyr 
225                 230                 235                 240 


Val Ala Thr Leu Leu Leu Ser Val Leu Ala Tyr Glu Gln Arg Pro Pro 
                245                 250                 255     


Leu Gly Pro Gly Thr Leu Leu Ser Leu Leu Ser Leu Gly Ser Ala Ser 
            260                 265                 270         


Ala Ala Ala Val Pro Val Ala Met Gly Leu Gly Asp Gln Arg Tyr Thr 
        275                 280                 285             


Ala Pro Trp Arg Ala Ala Ala Gln Arg Cys Leu Gln Gly Leu Trp Gly 
    290                 295                 300                 


Arg Ala Ser Arg Asp Ser Pro Gly Pro Ser Ile Ala Tyr His Pro Ser 
305                 310                 315                 320 


Ser Gln Ser Ser Val Asp Leu Asp Leu Asn 
                325                 330 


<210>  955
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  955

Met Ala Gln Phe Asp Thr Glu Tyr Gln Arg Leu Glu Ala Ser Tyr Ser 
1               5                   10                  15      


Asp Ser Pro Pro Gly Glu Glu Asp Leu Leu Val His Val Ala Glu Gly 
            20                  25                  30          


Ser Lys Ser Pro Trp His His Ile Glu Asn Leu Asp Leu Phe Phe Ser 
        35                  40                  45              


Arg Val Tyr Asn Leu His Gln Lys Asn Gly Phe Thr Cys Met Leu Ile 
    50                  55                  60                  


Gly Glu Ile Phe Glu Leu Met Gln Phe Leu Phe Val Val Ala Phe Thr 
65                  70                  75                  80  


Thr Phe Leu Val Ser Cys Val Asp Tyr Asp Ile Leu Phe Ala Asn Lys 
                85                  90                  95      


Met Val Asn His Ser Leu His Pro Thr Glu Pro Val Lys Val Thr Leu 
            100                 105                 110         


Pro Asp Ala Phe Leu Pro Ala Gln Val Cys Ser Ala Arg Ile Gln Glu 
        115                 120                 125             


Asn Gly Ser Leu Ile Thr Ile Leu Val Ile Ala Gly Val Phe Trp Ile 
    130                 135                 140                 


His Arg Leu Ile Lys Phe Ile Tyr Asn Ile Cys Cys Tyr Trp Glu Ile 
145                 150                 155                 160 


His Ser Phe Tyr Leu His Ala Leu Arg Ile Pro Met Ser Ala Leu Pro 
                165                 170                 175     


Tyr Cys Thr Trp Gln Glu Val Gln Ala Arg Ile Val Gln Thr Gln Lys 
            180                 185                 190         


Glu His Gln Ile Cys Ile His Lys Arg Glu Leu Thr Glu Leu Asp Ile 
        195                 200                 205             


Tyr His Arg Ile Leu Arg Phe Gln Asn Tyr Met Val Ala Leu Val Asn 
    210                 215                 220                 


Lys Ser Leu Leu Pro Leu Arg Phe Arg Leu Pro Gly Leu Gly Glu Ala 
225                 230                 235                 240 


Val Phe Phe Thr Arg Gly Leu Lys Tyr Asn Phe Glu Leu Ile Leu Phe 
                245                 250                 255     


Trp Gly Pro Gly Ser Leu Phe Leu Asn Glu Trp Ser Leu Lys Ala Glu 
            260                 265                 270         


Tyr Lys Arg Gly Gly Gln Arg Leu Glu Leu Ala Gln Arg Leu Ser Asn 
        275                 280                 285             


Arg Ile Leu Trp Ile Gly Ile Ala Asn Phe Leu Leu Cys Pro Leu Ile 
    290                 295                 300                 


Leu Ile Trp Gln Ile Leu Tyr Ala Phe Phe Ser Tyr Ala Glu Val Leu 
305                 310                 315                 320 


Lys Arg Glu Pro Gly Ala Leu Gly Ala Arg Cys Trp Ser Leu Tyr Gly 
                325                 330                 335     


Arg Cys Tyr Leu Arg His Phe Asn Glu Leu Glu His Glu Leu Gln Ser 
            340                 345                 350         


Arg Leu Asn Arg Gly Tyr Lys Pro Ala Ser Lys Tyr Met Asn Cys Phe 
        355                 360                 365             


Leu Ser Pro Leu Leu Thr Leu Leu Ala Lys Asn Gly Ala Phe Phe Ala 
    370                 375                 380                 


Gly Ser Ile Leu Ala Val Leu Ile Ala Leu Thr Ile Tyr Asp Glu Asp 
385                 390                 395                 400 


Val Leu Ala Val Glu His Val Leu Thr Thr Val Thr Leu Leu Gly Val 
                405                 410                 415     


Thr Val Thr Val Cys Arg Ser Phe Ile Pro Asp Gln His Met Val Phe 
            420                 425                 430         


Cys Pro Glu Gln Leu Leu Arg Val Ile Leu Ala His Ile His Tyr Met 
        435                 440                 445             


Pro Asp His Trp Gln Gly Asn Ala His Arg Ser Gln Thr Arg Asp Glu 
    450                 455                 460                 


Phe Ala Gln Leu Phe Gln Tyr Lys Ala Val Phe Ile Leu Glu Glu Leu 
465                 470                 475                 480 


Leu Ser Pro Ile Val Thr Pro Leu Ile Leu Ile Phe Cys Leu Arg Pro 
                485                 490                 495     


Arg Ala Leu Glu Ile Ile Asp Phe Phe Arg Asn Phe Thr Val Glu Val 
            500                 505                 510         


Val Gly Val Gly Asp Thr Cys Ser Phe Ala Gln Met Asp Val Arg Gln 
        515                 520                 525             


His Gly His Pro Gln Trp Leu Ser Ala Gly Gln Thr Glu Ala Ser Val 
    530                 535                 540                 


Tyr Gln Gln Ala Glu Asp Gly Lys Thr Glu Leu Ser Leu Met His Phe 
545                 550                 555                 560 


Ala Ile Thr Asn Pro Gly Trp Gln Pro Pro Arg Glu Ser Thr Ala Phe 
                565                 570                 575     


Leu Gly Phe Leu Lys Glu Gln Val Gln Arg Asp Gly Ala Ala Ala Ser 
            580                 585                 590         


Leu Ala Gln Gly Gly Leu Leu Pro Glu Asn Ala Leu Phe Thr Ser Ile 
        595                 600                 605             


Gln Ser Leu Gln Ser Glu Ser Glu Pro Leu Ser Leu Ile Ala Asn Val 
    610                 615                 620                 


Val Ala Gly Ser Ser Cys Arg Gly Pro Pro Leu Pro Arg Asp Leu Gln 
625                 630                 635                 640 


Gly Ser Arg His Arg Ala Glu Val Ala Ser Ala Leu Arg Ser Phe Ser 
                645                 650                 655     


Pro Leu Gln Pro Gly Gln Ala Pro Thr Gly Arg Ala His Ser Thr Met 
            660                 665                 670         


Thr Gly Ser Gly Val Asp Ala Arg Thr Ala Ser Ser Gly Ser Ser Val 
        675                 680                 685             


Trp Glu Gly Gln Leu Gln Ser Leu Val Leu Ser Glu Tyr Ala Ser Thr 
    690                 695                 700                 


Glu Met Ser Leu His Ala Leu Tyr Met His Gln Leu His Lys Gln Gln 
705                 710                 715                 720 


Ala Gln Ala Glu Pro Glu Arg His Val Trp His Arg Arg Glu Ser Asp 
                725                 730                 735     


Glu Ser Gly Glu Ser Ala Pro Asp Glu Gly Gly Glu Gly Ala Arg Ala 
            740                 745                 750         


Pro Gln Ser Ile Pro Arg Ser Ala Ser Tyr Pro Cys Ala Ala Pro Arg 
        755                 760                 765             


Pro Gly Ala Pro Glu Thr Thr Ala Leu His Gly Gly Phe Gln Arg Arg 
    770                 775                 780                 


Tyr Gly Gly Ile Thr Asp Pro Gly Thr Val Pro Arg Val Pro Ser His 
785                 790                 795                 800 


Phe Ser Arg Leu Pro Leu Gly Gly Trp Ala Glu Asp Gly Gln Ser Ala 
                805                 810                 815     


Ser Arg His Pro Glu Pro Val Pro Glu Glu Gly Ser Glu Asp Glu Leu 
            820                 825                 830         


Pro Pro Gln Val His Lys Val 
        835                 


<210>  956
<211>  511
<212>  PRT
<213>  Homo sapiens

<400>  956

Met Ala Ala Ala Val Ala Ala Ala Leu Ala Arg Leu Leu Ala Ala Phe 
1               5                   10                  15      


Leu Leu Leu Ala Ala Gln Val Ala Cys Glu Tyr Gly Met Val His Val 
            20                  25                  30          


Val Ser Gln Ala Gly Gly Pro Glu Gly Lys Asp Tyr Cys Ile Leu Tyr 
        35                  40                  45              


Asn Pro Gln Trp Ala His Leu Pro His Asp Leu Ser Lys Ala Ser Phe 
    50                  55                  60                  


Leu Gln Leu Arg Asn Trp Thr Ala Ser Leu Leu Cys Ser Ala Ala Asp 
65                  70                  75                  80  


Leu Pro Ala Arg Gly Phe Ser Asn Gln Ile Pro Leu Val Ala Arg Gly 
                85                  90                  95      


Asn Cys Thr Phe Tyr Glu Lys Val Arg Leu Ala Gln Gly Ser Gly Ala 
            100                 105                 110         


Arg Gly Leu Leu Ile Val Ser Arg Glu Arg Leu Val Pro Pro Gly Gly 
        115                 120                 125             


Asn Lys Thr Gln Tyr Asp Glu Ile Gly Ile Pro Val Ala Leu Leu Ser 
    130                 135                 140                 


Tyr Lys Asp Met Leu Asp Ile Phe Thr Arg Phe Gly Arg Thr Val Arg 
145                 150                 155                 160 


Ala Ala Leu Tyr Ala Pro Lys Glu Pro Val Leu Asp Tyr Asn Met Val 
                165                 170                 175     


Ile Ile Phe Ile Met Ala Val Gly Thr Val Ala Ile Gly Gly Tyr Trp 
            180                 185                 190         


Ala Gly Ser Arg Asp Val Lys Lys Arg Tyr Met Lys His Lys Arg Asp 
        195                 200                 205             


Asp Gly Pro Glu Lys Gln Glu Asp Glu Ala Val Asp Val Thr Pro Val 
    210                 215                 220                 


Met Thr Cys Val Phe Val Val Met Cys Cys Ser Met Leu Val Leu Leu 
225                 230                 235                 240 


Tyr Tyr Phe Tyr Asp Leu Leu Val Tyr Val Val Ile Gly Ile Phe Cys 
                245                 250                 255     


Leu Ala Ser Ala Thr Gly Leu Tyr Ser Cys Leu Ala Pro Cys Val Arg 
            260                 265                 270         


Arg Leu Pro Phe Gly Lys Cys Arg Ile Pro Asn Asn Ser Leu Pro Tyr 
        275                 280                 285             


Phe His Lys Arg Pro Gln Ala Arg Met Leu Leu Leu Ala Leu Phe Cys 
    290                 295                 300                 


Val Ala Val Ser Val Val Trp Gly Val Phe Arg Asn Glu Asp Gln Trp 
305                 310                 315                 320 


Ala Trp Val Leu Gln Asp Ala Leu Gly Ile Ala Phe Cys Leu Tyr Met 
                325                 330                 335     


Leu Lys Thr Ile Arg Leu Pro Thr Phe Lys Ala Cys Thr Leu Leu Leu 
            340                 345                 350         


Leu Val Leu Phe Leu Tyr Asp Ile Phe Phe Val Phe Ile Thr Pro Phe 
        355                 360                 365             


Leu Thr Lys Ser Gly Ser Ser Ile Met Val Glu Val Ala Thr Gly Pro 
    370                 375                 380                 


Ser Asp Ser Ala Thr Arg Glu Lys Leu Pro Met Val Leu Lys Val Pro 
385                 390                 395                 400 


Arg Leu Asn Ser Ser Pro Leu Ala Leu Cys Asp Arg Pro Phe Ser Leu 
                405                 410                 415     


Leu Gly Phe Gly Asp Ile Leu Val Pro Gly Leu Leu Val Ala Tyr Cys 
            420                 425                 430         


His Arg Phe Asp Ile Gln Val Gln Ser Ser Arg Val Tyr Phe Val Ala 
        435                 440                 445             


Cys Thr Ile Ala Tyr Gly Val Gly Leu Leu Val Thr Phe Val Ala Leu 
    450                 455                 460                 


Ala Leu Met Gln Arg Gly Gln Pro Ala Leu Leu Tyr Leu Val Pro Cys 
465                 470                 475                 480 


Thr Leu Val Thr Ser Cys Ala Val Ala Leu Trp Arg Arg Glu Leu Gly 
                485                 490                 495     


Val Phe Trp Thr Gly Ser Gly Phe Ala Val Asn Thr Ser Leu Leu 
            500                 505                 510     


<210>  957
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  957

Met Val Lys Ile Tyr Arg His Glu Ser Leu Leu Gly Phe Phe Lys Gly 
1               5                   10                  15      


Met Ser Phe Pro Ile Ala Ser Ile Ala Val Val Asn Ser Val Leu Phe 
            20                  25                  30          


Gly Val Tyr Ser Asn Thr Leu Leu Val Leu Thr Ala Thr Ser His Gln 
        35                  40                  45              


Glu Arg Arg Ala Gln Pro Pro Ser Tyr Met His Ile Phe Leu Ala Gly 
    50                  55                  60                  


Cys Thr Gly Gly Phe Leu Gln Ala Tyr Cys Leu Ala Pro Phe Asp Leu 
65                  70                  75                  80  


Ile Lys Val Arg Leu Gln Asn Gln Thr Glu Pro Arg Ala Gln Pro Gly 
                85                  90                  95      


Ser Pro Pro Pro Arg Tyr Gln Gly Pro Val His Cys Ala Ala Ser Ile 
            100                 105                 110         


Phe Arg Glu Glu Gly Pro Arg Gly Leu Phe Arg Gly Ala Trp Ala Leu 
        115                 120                 125             


Thr Leu Arg Asp Thr Pro Thr Val Gly Ile Tyr Phe Ile Thr Tyr Glu 
    130                 135                 140                 


Gly Leu Cys Arg Gln Tyr Thr Pro Glu Gly Gln Asn Pro Ser Ser Ala 
145                 150                 155                 160 


Thr Val Leu Val Ala Gly Gly Phe Ala Gly Ile Ala Ser Trp Val Ala 
                165                 170                 175     


Ala Thr Pro Leu Asp Val Ile Lys Ser Arg Met Gln Met Asp Gly Leu 
            180                 185                 190         


Arg Arg Arg Val Tyr Gln Gly Met Leu Asp Cys Met Val Ser Ser Ile 
        195                 200                 205             


Arg Gln Glu Gly Leu Gly Val Phe Phe Arg Gly Val Thr Ile Asn Ser 
    210                 215                 220                 


Ala Arg Ala Phe Pro Val Asn Ala Val Thr Phe Leu Ser Tyr Glu Tyr 
225                 230                 235                 240 


Leu Leu Arg Trp Trp Gly 
                245     


<210>  958
<211>  884
<212>  PRT
<213>  Homo sapiens

<400>  958

Met Arg Ile Ile Ser Arg Gln Ile Val Leu Leu Phe Ser Gly Phe Trp 
1               5                   10                  15      


Gly Leu Ala Met Gly Ala Phe Pro Ser Ser Val Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Ile Arg Asn Thr Asp Gln Glu Tyr Thr Ala Phe Arg Leu Ala Ile 
        35                  40                  45              


Phe Leu His Asn Thr Ser Pro Asn Ala Ser Glu Ala Pro Phe Asn Leu 
    50                  55                  60                  


Val Pro His Val Asp Asn Ile Glu Thr Ala Asn Ser Phe Ala Val Thr 
65                  70                  75                  80  


Asn Ala Phe Cys Ser Gln Tyr Ser Arg Gly Val Phe Ala Ile Phe Gly 
                85                  90                  95      


Leu Tyr Asp Lys Arg Ser Val His Thr Leu Thr Ser Phe Cys Ser Ala 
            100                 105                 110         


Leu His Ile Ser Leu Ile Thr Pro Ser Phe Pro Thr Glu Gly Glu Ser 
        115                 120                 125             


Gln Phe Val Leu Gln Leu Arg Pro Ser Leu Arg Gly Ala Leu Leu Ser 
    130                 135                 140                 


Leu Leu Asp His Tyr Glu Trp Asn Cys Phe Val Phe Leu Tyr Asp Thr 
145                 150                 155                 160 


Asp Arg Gly Tyr Ser Ile Leu Gln Ala Ile Met Glu Lys Ala Gly Gln 
                165                 170                 175     


Asn Gly Trp His Val Ser Ala Ile Cys Val Glu Asn Phe Asn Asp Val 
            180                 185                 190         


Ser Tyr Arg Gln Leu Leu Glu Glu Leu Asp Arg Arg Gln Glu Lys Lys 
        195                 200                 205             


Phe Val Ile Asp Cys Glu Ile Glu Arg Leu Gln Asn Ile Leu Glu Gln 
    210                 215                 220                 


Ile Val Ser Val Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala 
225                 230                 235                 240 


Asn Leu Gly Phe Lys Asp Ile Ser Leu Glu Arg Phe Ile His Gly Gly 
                245                 250                 255     


Ala Asn Val Thr Gly Phe Gln Leu Val Asp Phe Asn Thr Pro Met Val 
            260                 265                 270         


Ile Lys Leu Met Asp Arg Trp Lys Lys Leu Asp Gln Arg Glu Tyr Pro 
        275                 280                 285             


Gly Ser Glu Thr Pro Pro Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Gly 
    290                 295                 300                 


Val Leu Val Met Ala Glu Thr Phe Arg Ser Leu Arg Arg Gln Lys Ile 
305                 310                 315                 320 


Asp Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala 
                325                 330                 335     


Ala Pro Trp Gly Gln Gly Ile Asp Met Glu Arg Thr Leu Lys Gln Val 
            340                 345                 350         


Arg Ile Gln Gly Leu Thr Gly Asn Val Gln Phe Asp His Tyr Gly Arg 
        355                 360                 365             


Arg Val Asn Tyr Thr Met Asp Val Phe Glu Leu Lys Ser Thr Gly Pro 
    370                 375                 380                 


Arg Lys Val Gly Tyr Trp Asn Asp Met Asp Lys Leu Val Leu Ile Gln 
385                 390                 395                 400 


Asp Val Pro Thr Leu Gly Asn Asp Thr Ala Ala Ile Glu Asn Arg Thr 
                405                 410                 415     


Val Val Val Thr Thr Ile Met Glu Ser Pro Tyr Val Met Tyr Lys Lys 
            420                 425                 430         


Asn His Glu Met Phe Glu Gly Asn Asp Lys Tyr Glu Gly Tyr Cys Val 
        435                 440                 445             


Asp Leu Ala Ser Glu Ile Ala Lys His Ile Gly Ile Lys Tyr Lys Ile 
    450                 455                 460                 


Ala Ile Val Pro Asp Gly Lys Tyr Gly Ala Arg Asp Ala Asp Thr Lys 
465                 470                 475                 480 


Ile Trp Asn Gly Met Val Gly Glu Leu Val Tyr Gly Lys Ala Glu Ile 
                485                 490                 495     


Ala Ile Ala Pro Leu Thr Ile Thr Leu Val Arg Glu Glu Val Ile Asp 
            500                 505                 510         


Phe Ser Lys Pro Phe Met Ser Leu Gly Ile Ser Ile Met Ile Lys Lys 
        515                 520                 525             


Pro Gln Lys Ser Lys Pro Gly Val Phe Ser Phe Leu Asp Pro Leu Ala 
    530                 535                 540                 


Tyr Glu Ile Trp Met Cys Ile Val Phe Ala Tyr Ile Gly Val Ser Val 
545                 550                 555                 560 


Val Leu Phe Leu Val Ser Arg Phe Ser Pro Tyr Glu Trp His Thr Glu 
                565                 570                 575     


Glu Pro Glu Asp Gly Lys Glu Gly Pro Ser Asp Gln Pro Pro Asn Glu 
            580                 585                 590         


Phe Gly Ile Phe Asn Ser Leu Trp Phe Ser Leu Gly Ala Phe Met Gln 
        595                 600                 605             


Gln Gly Cys Asp Ile Ser Pro Arg Ser Leu Ser Gly Arg Ile Val Gly 
    610                 615                 620                 


Gly Val Trp Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala 
625                 630                 635                 640 


Asn Leu Ala Ala Phe Leu Thr Val Glu Arg Met Val Ser Pro Ile Glu 
                645                 650                 655     


Ser Ala Glu Asp Leu Ala Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu 
            660                 665                 670         


Asp Ser Gly Ser Thr Lys Glu Phe Phe Arg Arg Ser Lys Ile Ala Val 
        675                 680                 685             


Tyr Glu Lys Met Trp Thr Tyr Met Arg Ser Ala Glu Pro Ser Val Phe 
    690                 695                 700                 


Thr Arg Thr Thr Ala Glu Gly Val Ala Arg Val Arg Lys Ser Lys Gly 
705                 710                 715                 720 


Lys Phe Ala Phe Leu Leu Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln 
                725                 730                 735     


Arg Lys Pro Cys Asp Thr Met Lys Val Gly Gly Asn Leu Asp Ser Lys 
            740                 745                 750         


Gly Tyr Gly Val Ala Thr Pro Lys Gly Ser Ser Leu Gly Asn Ala Val 
        755                 760                 765             


Asn Leu Ala Val Leu Lys Leu Asn Glu Gln Gly Leu Leu Asp Lys Leu 
    770                 775                 780                 


Lys Asn Lys Trp Trp Tyr Asp Lys Gly Glu Cys Gly Ser Gly Gly Gly 
785                 790                 795                 800 


Asp Ser Lys Asp Lys Thr Ser Ala Leu Ser Leu Ser Asn Val Ala Gly 
                805                 810                 815     


Val Phe Tyr Ile Leu Val Gly Gly Leu Gly Leu Ala Met Leu Val Ala 
            820                 825                 830         


Leu Ile Glu Phe Cys Tyr Lys Ser Arg Ala Glu Ala Lys Arg Met Lys 
        835                 840                 845             


Val Ala Lys Ser Ala Gln Thr Phe Asn Pro Thr Ser Ser Gln Asn Thr 
    850                 855                 860                 


Gln Asn Leu Ala Thr Tyr Arg Glu Gly Tyr Asn Val Tyr Gly Thr Glu 
865                 870                 875                 880 


Ser Ile Lys Ile 
                


<210>  959
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  959

Met Arg Ile Ile Ser Arg Gln Ile Val Leu Leu Phe Ser Gly Phe Trp 
1               5                   10                  15      


Gly Leu Ala Met Gly Ala Phe Pro Ser Ser Val Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Ile Arg Asn Thr Asp Gln Glu Tyr Thr Ala Phe Arg Leu Ala Ile 
        35                  40                  45              


Phe Leu His Asn Thr Ser Pro Asn Ala Ser Glu Ala Pro Phe Asn Leu 
    50                  55                  60                  


Val Pro His Val Asp Asn Ile Glu Thr Ala Asn Ser Phe Ala Val Thr 
65                  70                  75                  80  


Asn Ala Phe Cys Ser Gln Tyr Ser Arg Gly Val Phe Ala Ile Phe Gly 
                85                  90                  95      


Leu Tyr Asp Lys Arg Ser Val His Thr Leu Thr Ser Phe Cys Ser Ala 
            100                 105                 110         


Leu His Ile Ser Leu Ile Thr Pro Ser Phe Pro Thr Glu Gly Glu Ser 
        115                 120                 125             


Gln Phe Val Leu Gln Leu Arg Pro Ser Leu Arg Gly Ala Leu Leu Ser 
    130                 135                 140                 


Leu Leu Asp His Tyr Glu Trp Asn Cys Phe Val Phe Leu Tyr Asp Thr 
145                 150                 155                 160 


Asp Arg Gly Tyr Ser Ile Leu Gln Ala Ile Met Glu Lys Ala Gly Gln 
                165                 170                 175     


Asn Gly Trp His Val Ser Ala Ile Cys Val Glu Asn Phe Asn Asp Val 
            180                 185                 190         


Ser Tyr Arg Gln Leu Leu Glu Glu Leu Asp Arg Arg Gln Glu Lys Lys 
        195                 200                 205             


Phe Val Ile Asp Cys Glu Ile Glu Arg Leu Gln Asn Ile Leu Glu Gln 
    210                 215                 220                 


Ile Val Ser Val Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala 
225                 230                 235                 240 


Asn Leu Gly Phe Lys Asp Ile Ser Leu Glu Arg Phe Ile His Gly Gly 
                245                 250                 255     


Ala Asn Val Thr Gly Phe Gln Leu Val Asp Phe Asn Thr Pro Met Val 
            260                 265                 270         


Ile Lys Leu Met Asp Arg Trp Lys Lys Leu Asp Gln Arg Glu Tyr Pro 
        275                 280                 285             


Gly Ser Glu Thr Pro Pro Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Gly 
    290                 295                 300                 


Val Leu Val Met Ala Glu Thr Phe Arg Ser Leu Arg Arg Gln Lys Ile 
305                 310                 315                 320 


Asp Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala 
                325                 330                 335     


Ala Pro Trp Gly Gln Gly Ile Asp Met Glu Arg Thr Leu Lys Gln Val 
            340                 345                 350         


Arg Ile Gln Gly Leu Thr Gly Asn Val Gln Phe Asp His Tyr Gly Arg 
        355                 360                 365             


Arg Val Asn Tyr Thr Met Asp Val Phe Glu Leu Lys Ser Thr Gly Pro 
    370                 375                 380                 


Arg Lys Val Gly Tyr Trp Asn Asp Met Asp Lys Leu Val Leu Ile Gln 
385                 390                 395                 400 


Asp Val Pro Thr Leu Gly Asn Asp Thr Ala Ala Ile Glu Asn Arg Thr 
                405                 410                 415     


Val Val Val Thr Thr Ile Met Pro Leu Met Lys Asn Pro Ile Leu Arg 
            420                 425                 430         


Asn 
    


<210>  960
<211>  567
<212>  PRT
<213>  Homo sapiens

<400>  960

Met Glu Arg Asp Ser His Gly Asn Ala Ser Pro Ala Arg Thr Pro Ser 
1               5                   10                  15      


Ala Gly Ala Ser Pro Ala Gln Ala Ser Pro Ala Gly Thr Pro Pro Gly 
            20                  25                  30          


Arg Ala Ser Pro Ala Gln Ala Ser Pro Ala Gln Ala Ser Pro Ala Gly 
        35                  40                  45              


Thr Pro Pro Gly Arg Ala Ser Pro Ala Gln Ala Ser Pro Ala Gly Thr 
    50                  55                  60                  


Pro Pro Gly Arg Ala Ser Pro Gly Arg Ala Ser Pro Ala Gln Ala Ser 
65                  70                  75                  80  


Pro Ala Gln Ala Ser Pro Ala Arg Ala Ser Pro Ala Leu Ala Ser Leu 
                85                  90                  95      


Ser Arg Ser Ser Ser Gly Arg Ser Ser Ser Ala Arg Ser Ala Ser Val 
            100                 105                 110         


Thr Thr Ser Pro Thr Arg Val Tyr Leu Val Arg Ala Thr Pro Val Gly 
        115                 120                 125             


Ala Val Pro Ile Arg Ser Ser Pro Ala Arg Ser Ala Pro Ala Thr Arg 
    130                 135                 140                 


Ala Thr Arg Glu Ser Pro Gly Thr Ser Leu Pro Lys Phe Thr Trp Arg 
145                 150                 155                 160 


Glu Gly Gln Lys Gln Leu Pro Leu Ile Gly Cys Val Leu Leu Leu Ile 
                165                 170                 175     


Ala Leu Val Val Ser Leu Ile Ile Leu Phe Gln Phe Trp Gln Gly His 
            180                 185                 190         


Thr Gly Ile Arg Tyr Lys Glu Gln Arg Glu Ser Cys Pro Lys His Ala 
        195                 200                 205             


Val Arg Cys Asp Gly Val Val Asp Cys Lys Leu Lys Ser Asp Glu Leu 
    210                 215                 220                 


Gly Cys Val Arg Phe Asp Trp Asp Lys Ser Leu Leu Lys Ile Tyr Ser 
225                 230                 235                 240 


Gly Ser Ser His Gln Trp Leu Pro Ile Cys Ser Ser Asn Trp Asn Asp 
                245                 250                 255     


Ser Tyr Ser Glu Lys Thr Cys Gln Gln Leu Gly Phe Glu Ser Ala His 
            260                 265                 270         


Arg Thr Thr Glu Val Ala His Arg Asp Phe Ala Asn Ser Phe Ser Ile 
        275                 280                 285             


Leu Arg Tyr Asn Ser Thr Ile Gln Glu Ser Leu His Arg Ser Glu Cys 
    290                 295                 300                 


Pro Ser Gln Arg Tyr Ile Ser Leu Gln Cys Ser His Cys Gly Leu Arg 
305                 310                 315                 320 


Ala Met Thr Gly Arg Ile Val Gly Gly Ala Leu Ala Ser Asp Ser Lys 
                325                 330                 335     


Trp Pro Trp Gln Val Ser Leu His Phe Gly Thr Thr His Ile Cys Gly 
            340                 345                 350         


Gly Thr Leu Ile Asp Ala Gln Trp Val Leu Thr Ala Ala His Cys Phe 
        355                 360                 365             


Phe Val Thr Arg Glu Lys Val Leu Glu Gly Trp Lys Val Tyr Ala Gly 
    370                 375                 380                 


Thr Ser Asn Leu His Gln Leu Pro Glu Ala Ala Ser Ile Ala Glu Ile 
385                 390                 395                 400 


Ile Ile Asn Ser Asn Tyr Thr Asp Glu Glu Asp Asp Tyr Asp Ile Ala 
                405                 410                 415     


Leu Met Arg Leu Ser Lys Pro Leu Thr Leu Ser Ala His Ile His Pro 
            420                 425                 430         


Ala Cys Leu Pro Met His Gly Gln Thr Phe Ser Leu Asn Glu Thr Cys 
        435                 440                 445             


Trp Ile Thr Gly Phe Gly Lys Thr Arg Glu Thr Asp Asp Lys Thr Ser 
    450                 455                 460                 


Pro Phe Leu Arg Glu Val Gln Val Asn Leu Ile Asp Phe Lys Lys Cys 
465                 470                 475                 480 


Asn Asp Tyr Leu Val Tyr Asp Ser Tyr Leu Thr Pro Arg Met Met Cys 
                485                 490                 495     


Ala Gly Asp Leu Arg Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly 
            500                 505                 510         


Gly Pro Leu Val Cys Glu Gln Asn Asn Arg Trp Tyr Leu Ala Gly Val 
        515                 520                 525             


Thr Ser Trp Gly Thr Gly Cys Gly Gln Arg Asn Lys Pro Gly Val Tyr 
    530                 535                 540                 


Thr Lys Val Thr Glu Val Leu Pro Trp Ile Tyr Ser Lys Met Glu Ser 
545                 550                 555                 560 


Glu Val Arg Phe Arg Lys Ser 
                565         


<210>  961
<211>  725
<212>  PRT
<213>  Homo sapiens

<400>  961

Met Trp Gly Phe Leu Lys Arg Pro Val Val Val Thr Ala Asp Ile Asn 
1               5                   10                  15      


Leu Ser Leu Val Ala Leu Thr Gly Met Gly Leu Leu Ser Arg Leu Trp 
            20                  25                  30          


Arg Leu Thr Tyr Pro Arg Ala Val Val Phe Asp Glu Val Tyr Tyr Gly 
        35                  40                  45              


Gln Tyr Ile Ser Phe Tyr Met Lys Gln Ile Phe Phe Leu Asp Asp Ser 
    50                  55                  60                  


Gly Pro Pro Phe Gly His Met Val Leu Ala Leu Gly Gly Tyr Leu Gly 
65                  70                  75                  80  


Gly Phe Asp Gly Asn Phe Leu Trp Asn Arg Ile Gly Ala Glu Tyr Ser 
                85                  90                  95      


Ser Asn Val Pro Val Trp Ser Leu Arg Leu Leu Pro Ala Leu Ala Gly 
            100                 105                 110         


Ala Leu Ser Val Pro Met Ala Tyr Gln Ile Val Leu Glu Leu His Phe 
        115                 120                 125             


Ser His Cys Ala Ala Met Gly Ala Ala Leu Leu Met Leu Ile Glu Asn 
    130                 135                 140                 


Ala Leu Ile Thr Gln Ser Arg Leu Met Leu Leu Glu Ser Val Leu Ile 
145                 150                 155                 160 


Phe Phe Asn Leu Leu Ala Val Leu Ser Tyr Leu Lys Phe Phe Asn Cys 
                165                 170                 175     


Gln Lys His Ser Pro Phe Ser Leu Ser Trp Trp Phe Trp Leu Thr Leu 
            180                 185                 190         


Thr Gly Val Ala Cys Ser Cys Ala Val Gly Ile Lys Tyr Met Gly Val 
        195                 200                 205             


Phe Thr Tyr Val Leu Val Leu Gly Val Ala Ala Val His Ala Trp His 
    210                 215                 220                 


Leu Leu Gly Asp Gln Thr Leu Ser Asn Val Cys Val Phe Cys His Leu 
225                 230                 235                 240 


Leu Ala Arg Ala Val Ala Leu Leu Val Ile Pro Val Val Leu Tyr Leu 
                245                 250                 255     


Leu Phe Phe Tyr Val His Leu Ile Leu Val Phe Arg Ser Gly Pro His 
            260                 265                 270         


Asp Gln Ile Met Ser Ser Ala Phe Gln Ala Ser Leu Glu Gly Gly Leu 
        275                 280                 285             


Ala Arg Ile Thr Gln Gly Gln Pro Leu Glu Val Ala Phe Gly Ser Gln 
    290                 295                 300                 


Val Thr Leu Arg Asn Val Phe Gly Lys Pro Val Pro Cys Trp Leu His 
305                 310                 315                 320 


Ser His Gln Asp Thr Tyr Pro Met Ile Tyr Glu Asn Gly Arg Gly Ser 
                325                 330                 335     


Ser His Gln Gln Gln Val Thr Cys Tyr Pro Phe Lys Asp Val Asn Asn 
            340                 345                 350         


Trp Trp Ile Val Lys Asp Pro Arg Arg His Gln Leu Val Val Ser Ser 
        355                 360                 365             


Pro Pro Arg Pro Val Arg His Gly Asp Met Val Gln Leu Val His Gly 
    370                 375                 380                 


Met Thr Thr Arg Ser Leu Asn Thr His Asp Val Ala Ala Pro Leu Ser 
385                 390                 395                 400 


Pro His Ser Gln Glu Val Ser Cys Tyr Ile Asp Tyr Asn Ile Ser Met 
                405                 410                 415     


Pro Ala Gln Asn Leu Trp Arg Leu Glu Ile Val Asn Arg Gly Ser Asp 
            420                 425                 430         


Thr Asp Val Trp Lys Thr Ile Leu Ser Glu Val Arg Phe Val His Val 
        435                 440                 445             


Asn Thr Ser Ala Val Leu Lys Leu Ser Gly Ala His Leu Pro Asp Trp 
    450                 455                 460                 


Gly Tyr Arg Gln Leu Glu Ile Val Gly Glu Lys Leu Ser Arg Gly Tyr 
465                 470                 475                 480 


His Gly Ser Thr Val Trp Asn Val Glu Glu His Arg Tyr Gly Ala Ser 
                485                 490                 495     


Gln Glu Gln Arg Glu Arg Glu Arg Glu Leu His Ser Pro Ala Gln Val 
            500                 505                 510         


Asp Val Ser Arg Asn Leu Ser Phe Met Ala Arg Phe Ser Glu Leu Gln 
        515                 520                 525             


Trp Arg Met Leu Ala Leu Arg Ser Asp Asp Ser Glu His Lys Tyr Ser 
    530                 535                 540                 


Ser Ser Pro Leu Glu Trp Val Thr Leu Asp Thr Asn Ile Ala Tyr Trp 
545                 550                 555                 560 


Leu His Pro Arg Thr Ser Ala Gln Ile His Leu Leu Gly Asn Ile Val 
                565                 570                 575     


Ile Trp Val Ser Gly Ser Leu Ala Leu Ala Ile Tyr Ala Leu Leu Ser 
            580                 585                 590         


Leu Trp Tyr Leu Leu Arg Arg Arg Arg Asn Val His Asp Leu Pro Gln 
        595                 600                 605             


Asp Ala Trp Leu Arg Trp Val Leu Ala Gly Ala Leu Cys Ala Gly Gly 
    610                 615                 620                 


Trp Ala Val Asn Tyr Leu Pro Phe Phe Leu Met Glu Lys Thr Leu Phe 
625                 630                 635                 640 


Leu Tyr His Tyr Leu Pro Ala Leu Thr Phe Gln Ile Leu Leu Leu Pro 
                645                 650                 655     


Val Val Leu Gln His Ile Ser Asp His Leu Cys Arg Ser Gln Leu Gln 
            660                 665                 670         


Arg Ser Ile Phe Ser Ala Leu Val Val Ala Trp Tyr Ser Ser Ala Cys 
        675                 680                 685             


His Val Ser Asn Thr Leu Arg Pro Leu Thr Tyr Gly Asp Lys Ser Leu 
    690                 695                 700                 


Ser Pro His Glu Leu Lys Ala Leu Arg Trp Lys Asp Ser Trp Asp Ile 
705                 710                 715                 720 


Leu Ile Arg Lys His 
                725 


<210>  962
<211>  671
<212>  PRT
<213>  Homo sapiens

<400>  962

Met Lys Gln Ile Phe Phe Leu Asp Asp Ser Gly Pro Pro Phe Gly His 
1               5                   10                  15      


Met Val Leu Ala Leu Gly Gly Tyr Leu Gly Gly Phe Asp Gly Asn Phe 
            20                  25                  30          


Leu Trp Asn Arg Ile Gly Ala Glu Tyr Ser Ser Asn Val Pro Val Trp 
        35                  40                  45              


Ser Leu Arg Leu Leu Pro Ala Leu Ala Gly Ala Leu Ser Val Pro Met 
    50                  55                  60                  


Ala Tyr Gln Ile Val Leu Glu Leu His Phe Ser His Cys Ala Ala Met 
65                  70                  75                  80  


Gly Ala Ala Leu Leu Met Leu Ile Glu Asn Ala Leu Ile Thr Gln Ser 
                85                  90                  95      


Arg Leu Met Leu Leu Glu Ser Val Leu Ile Phe Phe Asn Leu Leu Ala 
            100                 105                 110         


Val Leu Ser Tyr Leu Lys Phe Phe Asn Cys Gln Lys His Ser Pro Phe 
        115                 120                 125             


Ser Leu Ser Trp Trp Phe Trp Leu Thr Leu Thr Gly Val Ala Cys Ser 
    130                 135                 140                 


Cys Ala Val Gly Ile Lys Tyr Met Gly Val Phe Thr Tyr Val Leu Val 
145                 150                 155                 160 


Leu Gly Val Ala Ala Val His Ala Trp His Leu Leu Gly Asp Gln Thr 
                165                 170                 175     


Leu Ser Asn Val Cys Val Phe Cys His Leu Leu Ala Arg Ala Val Ala 
            180                 185                 190         


Leu Leu Val Ile Pro Val Val Leu Tyr Leu Leu Phe Phe Tyr Val His 
        195                 200                 205             


Leu Ile Leu Val Phe Arg Ser Gly Pro His Asp Gln Ile Met Ser Ser 
    210                 215                 220                 


Ala Phe Gln Ala Ser Leu Glu Gly Gly Leu Ala Arg Ile Thr Gln Gly 
225                 230                 235                 240 


Gln Pro Leu Glu Val Ala Phe Gly Ser Gln Val Thr Leu Arg Asn Val 
                245                 250                 255     


Phe Gly Lys Pro Val Pro Cys Trp Leu His Ser His Gln Asp Thr Tyr 
            260                 265                 270         


Pro Met Ile Tyr Glu Asn Gly Arg Gly Ser Ser His Gln Gln Gln Val 
        275                 280                 285             


Thr Cys Tyr Pro Phe Lys Asp Val Asn Asn Trp Trp Ile Val Lys Asp 
    290                 295                 300                 


Pro Arg Arg His Gln Leu Val Val Ser Ser Pro Pro Arg Pro Val Arg 
305                 310                 315                 320 


His Gly Asp Met Val Gln Leu Val His Gly Met Thr Thr Arg Ser Leu 
                325                 330                 335     


Asn Thr His Asp Val Ala Ala Pro Leu Ser Pro His Ser Gln Glu Val 
            340                 345                 350         


Ser Cys Tyr Ile Asp Tyr Asn Ile Ser Met Pro Ala Gln Asn Leu Trp 
        355                 360                 365             


Arg Leu Glu Ile Val Asn Arg Gly Ser Asp Thr Asp Val Trp Lys Thr 
    370                 375                 380                 


Ile Leu Ser Glu Val Arg Phe Val His Val Asn Thr Ser Ala Val Leu 
385                 390                 395                 400 


Lys Leu Ser Gly Ala His Leu Pro Asp Trp Gly Tyr Arg Gln Leu Glu 
                405                 410                 415     


Ile Val Gly Glu Lys Leu Ser Arg Gly Tyr His Gly Ser Thr Val Trp 
            420                 425                 430         


Asn Val Glu Glu His Arg Tyr Gly Ala Ser Gln Glu Gln Arg Glu Arg 
        435                 440                 445             


Glu Arg Glu Leu His Ser Pro Ala Gln Val Asp Val Ser Arg Asn Leu 
    450                 455                 460                 


Ser Phe Met Ala Arg Phe Ser Glu Leu Gln Trp Arg Met Leu Ala Leu 
465                 470                 475                 480 


Arg Ser Asp Asp Ser Glu His Lys Tyr Ser Ser Ser Pro Leu Glu Trp 
                485                 490                 495     


Val Thr Leu Asp Thr Asn Ile Ala Tyr Trp Leu His Pro Arg Thr Ser 
            500                 505                 510         


Ala Gln Ile His Leu Leu Gly Asn Ile Val Ile Trp Val Ser Gly Ser 
        515                 520                 525             


Leu Ala Leu Ala Ile Tyr Ala Leu Leu Ser Leu Trp Tyr Leu Leu Arg 
    530                 535                 540                 


Arg Arg Arg Asn Val His Asp Leu Pro Gln Asp Ala Trp Leu Arg Trp 
545                 550                 555                 560 


Val Leu Ala Gly Ala Leu Cys Ala Gly Gly Trp Ala Val Asn Tyr Leu 
                565                 570                 575     


Pro Phe Phe Leu Met Glu Lys Thr Leu Phe Leu Tyr His Tyr Leu Pro 
            580                 585                 590         


Ala Leu Thr Phe Gln Ile Leu Leu Leu Pro Val Val Leu Gln His Ile 
        595                 600                 605             


Ser Asp His Leu Cys Arg Ser Gln Leu Gln Arg Ser Ile Phe Ser Ala 
    610                 615                 620                 


Leu Val Val Ala Trp Tyr Ser Ser Ala Cys His Val Ser Asn Thr Leu 
625                 630                 635                 640 


Arg Pro Leu Thr Tyr Gly Asp Lys Ser Leu Ser Pro His Glu Leu Lys 
                645                 650                 655     


Ala Leu Arg Trp Lys Asp Ser Trp Asp Ile Leu Ile Arg Lys His 
            660                 665                 670     


<210>  963
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  963

Met Ala Ala Val Val Ala Ala Thr Ala Leu Lys Gly Arg Gly Ala Arg 
1               5                   10                  15      


Asn Ala Arg Val Leu Arg Gly Ile Leu Ala Gly Ala Thr Ala Asn Lys 
            20                  25                  30          


Ala Ser His Asn Arg Thr Arg Ala Leu Gln Ser His Ser Ser Pro Glu 
        35                  40                  45              


Gly Lys Glu Glu Pro Glu Pro Leu Ser Pro Glu Leu Glu Tyr Ile Pro 
    50                  55                  60                  


Arg Lys Arg Gly Lys Asn Pro Met Lys Ala Val Gly Leu Ala Trp Ala 
65                  70                  75                  80  


Ile Gly Phe Pro Cys Gly Ile Leu Leu Phe Ile Leu Thr Lys Arg Glu 
                85                  90                  95      


Val Asp Lys Asp Arg Val Lys Gln Met Lys Ala Arg Gln Asn Met Arg 
            100                 105                 110         


Leu Ser Asn Thr Gly Glu Tyr Glu Ser Gln Arg Phe Arg Ala Ser Ser 
        115                 120                 125             


Gln Ser Ala Pro Ser Pro Asp Val Gly Ser Gly Val Gln Thr 
    130                 135                 140         


<210>  964
<211>  2057
<212>  PRT
<213>  Homo sapiens

<400>  964

Met Leu Arg Leu Val Val Gln Ser Ala Lys Ile Asp Pro Pro Leu Ala 
1               5                   10                  15      


Pro Leu Pro Arg Pro Cys Met Ser Ile Asp Phe Arg Asp Ile Lys Lys 
            20                  25                  30          


Arg Thr Arg Val Val Glu Gly Asn Asp Pro Val Trp Asn Glu Thr Leu 
        35                  40                  45              


Ile Trp His Leu Trp Asn Arg Pro Leu Glu Asn Asp Ser Phe Leu Gln 
    50                  55                  60                  


Val Thr Leu Gln Asp Met Gly Ser Gln Lys Lys Glu Arg Phe Ile Gly 
65                  70                  75                  80  


Leu Ala Thr Val Leu Leu Lys Pro Leu Leu Lys Gln Pro Ser Glu Val 
                85                  90                  95      


Leu Phe Val Lys Asp Leu Thr Leu Leu Asn His Ser Met Lys Pro Thr 
            100                 105                 110         


Asp Cys Thr Val Thr Leu Gln Val Ala His Met Ser Asn Gln Asp Ile 
        115                 120                 125             


Glu Lys Thr Gly Ala Glu Asp His Leu Gly Ile Thr Ala Arg Glu Ala 
    130                 135                 140                 


Ala Ser Gln Lys Leu Met Val Pro Gly Ser Thr Ala His Arg Ala Leu 
145                 150                 155                 160 


Ser Ser Lys Pro Gln His Phe Gln Val Arg Val Lys Val Phe Glu Ala 
                165                 170                 175     


Arg Gln Leu Met Gly Asn Asn Ile Lys Pro Val Val Lys Val Ser Ile 
            180                 185                 190         


Ala Gly Gln Gln His Gln Thr Arg Ile Lys Met Gly Asn Asn Pro Phe 
        195                 200                 205             


Phe Asn Glu Ile Phe Phe Gln Asn Phe His Glu Val Pro Ala Lys Phe 
    210                 215                 220                 


Phe Asp Glu Thr Ile Leu Ile Gln Val Val Asn Ser Ser Ala Met Arg 
225                 230                 235                 240 


Tyr Lys Ala Glu Ile Gly Arg Phe Gln Thr Asp Ile Gly Phe Ile Tyr 
                245                 250                 255     


His Ser Pro Gly His Thr Leu Leu Arg Lys Trp Leu Gly Leu Cys Gln 
            260                 265                 270         


Pro Asn Asn Pro Gly Ser Gly Val Thr Gly Tyr Leu Lys Val Thr Ile 
        275                 280                 285             


Tyr Ala Leu Gly Val Gly Asp Gln Ala Leu Ile Asp Gln Lys Leu Leu 
    290                 295                 300                 


Tyr Gly Thr Asp Asp Thr Asp Ile Gln Ile Phe Lys Ser Ala Val Val 
305                 310                 315                 320 


Pro Ile Asn Met Ala Tyr Leu Gln Leu Phe Ile Tyr Cys Ala Glu Asp 
                325                 330                 335     


Leu His Leu Lys Lys His Gln Ser Val Asn Pro Gln Leu Glu Val Glu 
            340                 345                 350         


Leu Ile Gly Glu Lys Leu Arg Thr His Met Gln Thr Gln Thr Asp Asn 
        355                 360                 365             


Pro Ile Trp Asn Gln Ile Leu Thr Phe Arg Ile Gln Leu Pro Cys Leu 
    370                 375                 380                 


Ser Ser Tyr Ile Lys Phe Arg Val Leu Asp Cys Arg Lys Lys Asp Cys 
385                 390                 395                 400 


Pro Asp Glu Ile Gly Thr Ala Ser Leu Ser Leu Asn Gln Ile Ser Ser 
                405                 410                 415     


Thr Gly Glu Glu Ile Glu Gly Val Tyr Ser Gly Phe Leu Pro Cys Phe 
            420                 425                 430         


Gly Pro Ser Phe Leu Thr Leu His Gly Gly Lys Lys Ala Pro Phe Arg 
        435                 440                 445             


Ile Gln Glu Glu Gly Ala Cys Ile Pro Asp Ser Val Arg Asp Gly Leu 
    450                 455                 460                 


Ala Tyr Arg Gly Arg Val Phe Leu Glu Leu Ile Thr Gln Ile Lys Ser 
465                 470                 475                 480 


Tyr Gln Asp Ser Thr Ile Lys Asp Leu Ser His Glu Val Thr Arg Ile 
                485                 490                 495     


Glu Lys His Gln Asn Arg Gln Lys Tyr Gly Leu Cys Val Ile Phe Leu 
            500                 505                 510         


Ser Cys Thr Met Met Pro Asn Phe Lys Glu Leu Ile His Phe Glu Val 
        515                 520                 525             


Ser Ile Gly His Tyr Gly Asn Lys Met Asp Leu Asn Tyr Lys Pro Leu 
    530                 535                 540                 


Val Ser Ser Thr Pro Tyr Ser Pro Val Ile Tyr Asp Gly Asn Ile Tyr 
545                 550                 555                 560 


His Tyr Val Pro Trp Tyr Asn Thr Lys Pro Val Val Ala Val Thr Ser 
                565                 570                 575     


Asn Trp Glu Asp Val Ser Phe Arg Met Asn Cys Leu Asn Leu Leu His 
            580                 585                 590         


Phe Thr Arg Asp Arg Leu Lys Ala Asn Leu Asp Thr Leu Lys Ser Thr 
        595                 600                 605             


Arg Asn Pro Lys Asp Pro Ala Leu Leu Tyr Gln Trp Glu Lys Leu Leu 
    610                 615                 620                 


Arg Glu Leu Ala Glu Asp Cys Lys Arg Pro Leu Pro Cys Met Thr Tyr 
625                 630                 635                 640 


Gln Pro Lys Ala Thr Ser Leu Asp Arg Lys Arg Trp Gln Leu Arg Ser 
                645                 650                 655     


Leu Leu Leu Gln Glu Leu Ala Gln Lys Ala Lys Gln Ala Lys Pro Lys 
            660                 665                 670         


Asp Met Val Ala Thr Ala Glu Asp Trp Leu Tyr Arg Leu Asn Thr Val 
        675                 680                 685             


Leu Pro Glu Pro Gln Met Gly Leu Pro Asp Val Met Ile Trp Leu Val 
    690                 695                 700                 


Ala Lys Glu Gln Arg Val Ala Tyr Ala Gln Val Pro Ala His Ser Val 
705                 710                 715                 720 


Leu Phe Ser Pro Ala Gly Ala Leu His Ser Gly Arg Leu Cys Gly Lys 
                725                 730                 735     


Ile Gln Thr Leu Phe Leu Gln Tyr Pro Glu Gly Glu Gly Gln Lys Asp 
            740                 745                 750         


Val Leu Pro Ala His Leu Arg Val Cys Met Trp Leu Gly Asn Val Thr 
        755                 760                 765             


Asp Ser Lys Asp Leu Gln Leu Leu Arg Gln Gly Asp Thr Ala Val Tyr 
    770                 775                 780                 


Ala Glu Met Tyr Glu Asn Gln Ala Lys Tyr Lys Asp Gln Trp Gly Gln 
785                 790                 795                 800 


Gln Gly Leu Tyr His Cys Pro Asn Phe Ser Asp Val Met Gly Asn Lys 
                805                 810                 815     


Thr Leu Pro Met Thr Asp Phe Gln Pro Pro Leu Gly Trp His Trp Gln 
            820                 825                 830         


Asp Ser Trp Thr Val Glu Pro Gln Arg Arg Leu Leu Leu Asp Ile Asp 
        835                 840                 845             


Ile Asn Lys Ser Gln Val Leu Glu Glu Val Tyr Glu Asn Gln Gly Arg 
    850                 855                 860                 


Asp Thr Arg Gly Ala Trp Gly Pro Ala Ala Ile Pro Asn Thr Asp Val 
865                 870                 875                 880 


Asn Gly Gln Pro Met Glu Ala Arg Glu Asn Val Lys Cys Pro Gln Gly 
                885                 890                 895     


Trp His Phe Lys Lys Asp Trp Val Val Glu Leu Asn His Ala Val Asp 
            900                 905                 910         


Ser Lys Gly Trp Glu Tyr Gly Val Gly Ile Pro Pro Ser Gly Leu Pro 
        915                 920                 925             


Gln Val Trp Ser Pro Val Glu Lys Thr Tyr His Ser Cys Arg Arg Arg 
    930                 935                 940                 


Arg Trp Ala Arg Val Arg Phe Arg Asn His Gly Glu Leu Ser His Glu 
945                 950                 955                 960 


Gln Glu Thr Leu Ser Phe Leu Gln Leu Gly Leu Ala Lys Gly Glu Glu 
                965                 970                 975     


Glu Gly Trp Glu Tyr Asp Thr Phe Gly Ser Lys Phe His Leu Asn Pro 
            980                 985                 990         


Gln Pro Gln Ser Arg Phe Arg Arg  Arg Cys Trp Arg Arg  Arg Leu Ala 
        995                 1000                 1005             


Pro Asn  Lys Asp Lys Gly Ile  Ala Pro Ile Phe Leu  Leu Glu Gly 
    1010                 1015                 1020             


Ser Leu  Ala Met Asp Leu Lys  Tyr His Ala Gly Lys  Glu Glu Asp 
    1025                 1030                 1035             


Ser Lys  Thr Trp Pro Trp Gly  Leu Asp Arg Gln Phe  Arg Asp Pro 
    1040                 1045                 1050             


Gln Arg  Gln Asp Thr Arg Pro  Pro Asn Leu Pro Phe  Ile Tyr Cys 
    1055                 1060                 1065             


Thr Phe  Asn Lys Pro His Tyr  Tyr Gln Leu Phe Cys  Tyr Ile Tyr 
    1070                 1075                 1080             


Gln Ala  Arg Asn Leu Val Ser  Asn Gln Ile Leu Thr  Phe Gln Gly 
    1085                 1090                 1095             


Pro Phe  Ile Arg Val Val Phe  Leu Asn His Ser Gln  Cys Thr Gln 
    1100                 1105                 1110             


Thr Leu  Arg Ser Ser Ala Gly  Pro Thr Trp Ala Gln  Thr Leu Ile 
    1115                 1120                 1125             


Phe Gln  His Leu Leu Leu Tyr  Glu Asn Pro Gln Asp  Thr Lys Glu 
    1130                 1135                 1140             


Ser Pro  Pro Leu Val Val Leu  Glu Leu Trp Gln Arg  Asp Phe Trp 
    1145                 1150                 1155             


Gly Lys  Glu Ser Leu Trp Gly  Arg Ser Val Trp Pro  Pro Met Val 
    1160                 1165                 1170             


Trp Leu  Asp Leu Gln Asp Arg  Ile Leu Pro Pro Met  Arg Trp His 
    1175                 1180                 1185             


Pro Leu  Val Lys Glu Leu Gly  Lys Glu Glu Gly Glu  Ile Leu Ala 
    1190                 1195                 1200             


Ser Cys  Glu Leu Ile Leu Gln  Thr Glu Lys Leu Gly  Glu Lys Gln 
    1205                 1210                 1215             


Leu Pro  Ile Leu Ser Val Pro  Trp Lys Asn Gly Ala  Tyr Thr Leu 
    1220                 1225                 1230             


Pro Lys  Ser Ile Gln Pro Thr  Ile Lys Arg Met Ala  Ile Glu Ile 
    1235                 1240                 1245             


Leu Ala  Trp Gly Leu Arg Asn  Met Lys Lys Ala Ser  Ser Pro Gln 
    1250                 1255                 1260             


Leu Leu  Val Glu Phe Gly Glu  Glu Ser Leu Arg Thr  Glu Pro Ile 
    1265                 1270                 1275             


Arg Asp  Phe Gln Thr Asn Pro  Asn Phe Pro Glu Ser  Glu Ser Val 
    1280                 1285                 1290             


Leu Val  Leu Thr Val Leu Met  Pro Thr Glu Glu Ala  Tyr Ala Leu 
    1295                 1300                 1305             


Pro Leu  Val Val Lys Val Val  Asp Asn Trp Ala Phe  Gly Gln Gln 
    1310                 1315                 1320             


Thr Val  Thr Gly Gln Ala Asn  Ile Asp Phe Leu Gln  Pro Tyr Phe 
    1325                 1330                 1335             


Cys Asp  Pro Trp Ala Gln Asp  Tyr Met His Pro Lys  Leu Pro Thr 
    1340                 1345                 1350             


Leu Ser  Glu Lys Lys His Gln  Asp Phe Leu Gly Tyr  Leu Tyr Arg 
    1355                 1360                 1365             


Lys Phe  Trp Phe Lys Ser Ser  Lys Ala Glu Asp Glu  Tyr Glu His 
    1370                 1375                 1380             


Glu Val  Asp Trp Trp Ser Lys  Leu Phe Trp Ala Thr  Asp Glu His 
    1385                 1390                 1395             


Lys Ser  Leu Lys Tyr Lys Tyr  Lys Asp Tyr His Thr  Leu Lys Val 
    1400                 1405                 1410             


Tyr Glu  Cys Glu Leu Glu Ala  Val Pro Ala Phe Gln  Gly Leu Gln 
    1415                 1420                 1425             


Asp Phe  Cys Gln Thr Phe Lys  Leu Tyr Gln Glu Gln  Pro Lys Leu 
    1430                 1435                 1440             


Asp Ser  Pro Val Val Gly Glu  Phe Lys Gly Leu Phe  Arg Ile Tyr 
    1445                 1450                 1455             


Pro Phe  Pro Glu Asn Pro Glu  Ala Pro Lys Pro Pro  Leu Gln Phe 
    1460                 1465                 1470             


Leu Val  Trp Pro Glu Arg Glu  Asp Phe Pro Gln Pro  Cys Leu Val 
    1475                 1480                 1485             


Arg Val  Tyr Met Val Arg Ala  Ile Asn Leu Gln Pro  Gln Asp Tyr 
    1490                 1495                 1500             


Asn Gly  Leu Cys Asp Pro Tyr  Val Ile Leu Lys Leu  Gly Lys Thr 
    1505                 1510                 1515             


Glu Leu  Gly Asn Arg Asp Met  Tyr Gln Pro Asn Thr  Leu Asp Pro 
    1520                 1525                 1530             


Ile Phe  Gly Met Met Phe Glu  Leu Thr Cys Asn Ile  Pro Leu Glu 
    1535                 1540                 1545             


Lys Asp  Leu Glu Ile Gln Leu  Tyr Asp Phe Asp Leu  Phe Ser Pro 
    1550                 1555                 1560             


Asp Asp  Lys Ile Gly Thr Thr  Val Ile Asp Leu Glu  Asn Arg Leu 
    1565                 1570                 1575             


Leu Ser  Gly Phe Gly Ala His  Cys Gly Leu Ser Lys  Ser Tyr Cys 
    1580                 1585                 1590             


Gln Ser  Gly Pro Phe Arg Trp  Arg Asp Gln Met Pro  Pro Ser Tyr 
    1595                 1600                 1605             


Leu Leu  Glu Arg Tyr Ala Lys  Arg Lys Gly Leu Pro  Pro Pro Leu 
    1610                 1615                 1620             


Phe Ser  Pro Glu Glu Asp Ala  Val Phe Tyr Asn Gly  Lys Lys Phe 
    1625                 1630                 1635             


Lys Leu  Gln Ser Phe Glu Pro  Lys Thr Pro Thr Val  His Gly Leu 
    1640                 1645                 1650             


Gly Pro  Lys Lys Glu Arg Leu  Ala Leu Tyr Leu Leu  His Thr Gln 
    1655                 1660                 1665             


Gly Leu  Val Pro Glu His Val  Glu Thr Arg Thr Leu  Tyr Ser His 
    1670                 1675                 1680             


Ser Gln  Pro Gly Ile Asp Gln  Gly Lys Val Gln Met  Trp Val Asp 
    1685                 1690                 1695             


Ile Phe  Pro Lys Lys Leu Gly  Pro Pro Gly Pro Gln  Val Asn Ile 
    1700                 1705                 1710             


Asn Pro  Arg Lys Pro Lys Arg  Tyr Glu Leu Arg Cys  Ile Ile Trp 
    1715                 1720                 1725             


Lys Thr  Ala Asn Val Asp Leu  Val Asp Asp Asn Leu  Ser Arg Glu 
    1730                 1735                 1740             


Lys Thr  Ser Asp Ile Tyr Ile  Lys Gly Trp Leu Tyr  Gly Leu Glu 
    1745                 1750                 1755             


Lys Asp  Met Gln Lys Thr Asp  Ile His Tyr His Ser  Leu Thr Gly 
    1760                 1765                 1770             


Glu Ala  Asp Phe Asn Trp Arg  Phe Ile Phe Thr Met  Asp Tyr Leu 
    1775                 1780                 1785             


Ala Ala  Glu Arg Thr Cys Val  Gln Ser Gln Lys Asp  Tyr Ile Trp 
    1790                 1795                 1800             


Ser Leu  Asp Ala Thr Ser Met  Lys Phe Pro Ala Arg  Leu Ile Ile 
    1805                 1810                 1815             


Gln Val  Trp Asp Asn Asp Ile  Phe Ser Pro Asp Asp  Phe Leu Gly 
    1820                 1825                 1830             


Val Leu  Glu Leu Asp Leu Ser  Asp Met Pro Leu Pro  Ala Arg His 
    1835                 1840                 1845             


Ala Lys  Gln Cys Ser Ile Arg  Met Met Asp Ala Asp  Pro Lys Trp 
    1850                 1855                 1860             


Pro Tyr  Phe Ile Gln Tyr Lys  His Phe Ser Leu Phe  Lys Lys Lys 
    1865                 1870                 1875             


Thr Val  Thr Gly Trp Trp Pro  Cys Gln Val Leu Asp  Gly Gly Lys 
    1880                 1885                 1890             


Trp Arg  Leu Ser Gly Lys Val  Lys Met Ser Leu Glu  Ile Leu Ser 
    1895                 1900                 1905             


Glu Lys  Glu Ala Leu Ile Lys  Pro Ala Gly Arg Gly  Gln Ser Glu 
    1910                 1915                 1920             


Pro Asn  Gln Tyr Pro Thr Leu  His Pro Pro Leu Arg  Thr Asn Thr 
    1925                 1930                 1935             


Ser Phe  Thr Trp Leu Arg Ser  Pro Val Gln Asn Phe  Cys Tyr Ile 
    1940                 1945                 1950             


Phe Trp  Lys Arg Tyr Arg Phe  Lys Leu Ile Ala Phe  Met Val Ile 
    1955                 1960                 1965             


Ser Ile  Ile Ala Leu Met Leu  Phe Asn Phe Ile Tyr  Ser Ala Pro 
    1970                 1975                 1980             


His Tyr  Leu Ala Met Ser Trp  Ile Lys Pro Gln Leu  Gln Leu Tyr 
    1985                 1990                 1995             


Pro Pro  Ile Lys Ile Phe Asn  Ile Ile Asn Ser Leu  Asn Thr Ser 
    2000                 2005                 2010             


Asn Ala  Ser Ser Ser Ile Leu  Pro Thr Gln Asp Pro  Asn Leu Lys 
    2015                 2020                 2025             


Pro Thr  Ile Asp His Glu Trp  Lys Leu His Pro Gly  Pro Thr Asn 
    2030                 2035                 2040             


His Leu  Ser Asp Ile Phe Pro  Glu Leu Pro Ala Pro  Gly Asp 
    2045                 2050                 2055         


<210>  965
<211>  503
<212>  PRT
<213>  Homo sapiens

<400>  965

Met Thr Leu Gly Ser Pro Arg Lys Gly Leu Leu Met Leu Leu Met Ala 
1               5                   10                  15      


Leu Val Thr Gln Gly Asp Pro Val Lys Pro Ser Arg Gly Pro Leu Val 
            20                  25                  30          


Thr Cys Thr Cys Glu Ser Pro His Cys Lys Gly Pro Thr Cys Arg Gly 
        35                  40                  45              


Ala Trp Cys Thr Val Val Leu Val Arg Glu Glu Gly Arg His Pro Gln 
    50                  55                  60                  


Glu His Arg Gly Cys Gly Asn Leu His Arg Glu Leu Cys Arg Gly Arg 
65                  70                  75                  80  


Pro Thr Glu Phe Val Asn His Tyr Cys Cys Asp Ser His Leu Cys Asn 
                85                  90                  95      


His Asn Val Ser Leu Val Leu Glu Ala Thr Gln Pro Pro Ser Glu Gln 
            100                 105                 110         


Pro Gly Thr Asp Gly Gln Leu Ala Leu Ile Leu Gly Pro Val Leu Ala 
        115                 120                 125             


Leu Leu Ala Leu Val Ala Leu Gly Val Leu Gly Leu Trp His Val Arg 
    130                 135                 140                 


Arg Arg Gln Glu Lys Gln Arg Gly Leu His Ser Glu Leu Gly Glu Ser 
145                 150                 155                 160 


Ser Leu Ile Leu Lys Ala Ser Glu Gln Gly Asp Ser Met Leu Gly Asp 
                165                 170                 175     


Leu Leu Asp Ser Asp Cys Thr Thr Gly Ser Gly Ser Gly Leu Pro Phe 
            180                 185                 190         


Leu Val Gln Arg Thr Val Ala Arg Gln Val Ala Leu Val Glu Cys Val 
        195                 200                 205             


Gly Lys Gly Arg Tyr Gly Glu Val Trp Arg Gly Leu Trp His Gly Glu 
    210                 215                 220                 


Ser Val Ala Val Lys Ile Phe Ser Ser Arg Asp Glu Gln Ser Trp Phe 
225                 230                 235                 240 


Arg Glu Thr Glu Ile Tyr Asn Thr Val Leu Leu Arg His Asp Asn Ile 
                245                 250                 255     


Leu Gly Phe Ile Ala Ser Asp Met Thr Ser Arg Asn Ser Ser Thr Gln 
            260                 265                 270         


Leu Trp Leu Ile Thr His Tyr His Glu His Gly Ser Leu Tyr Asp Phe 
        275                 280                 285             


Leu Gln Arg Gln Thr Leu Glu Pro His Leu Ala Leu Arg Leu Ala Val 
    290                 295                 300                 


Ser Ala Ala Cys Gly Leu Ala His Leu His Val Glu Ile Phe Gly Thr 
305                 310                 315                 320 


Gln Gly Lys Pro Ala Ile Ala His Arg Asp Phe Lys Ser Arg Asn Val 
                325                 330                 335     


Leu Val Lys Ser Asn Leu Gln Cys Cys Ile Ala Asp Leu Gly Leu Ala 
            340                 345                 350         


Val Met His Ser Gln Gly Ser Asp Tyr Leu Asp Ile Gly Asn Asn Pro 
        355                 360                 365             


Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Gln 
    370                 375                 380                 


Ile Arg Thr Asp Cys Phe Glu Ser Tyr Lys Trp Thr Asp Ile Trp Ala 
385                 390                 395                 400 


Phe Gly Leu Val Leu Trp Glu Ile Ala Arg Arg Thr Ile Val Asn Gly 
                405                 410                 415     


Ile Val Glu Asp Tyr Arg Pro Pro Phe Tyr Asp Val Val Pro Asn Asp 
            420                 425                 430         


Pro Ser Phe Glu Asp Met Lys Lys Val Val Cys Val Asp Gln Gln Thr 
        435                 440                 445             


Pro Thr Ile Pro Asn Arg Leu Ala Ala Asp Pro Val Leu Ser Gly Leu 
    450                 455                 460                 


Ala Gln Met Met Arg Glu Cys Trp Tyr Pro Asn Pro Ser Ala Arg Leu 
465                 470                 475                 480 


Thr Ala Leu Arg Ile Lys Lys Thr Leu Gln Lys Ile Ser Asn Ser Pro 
                485                 490                 495     


Glu Lys Pro Lys Val Ile Gln 
            500             


<210>  966
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  966

Met Ala Pro Trp Pro Pro Lys Gly Leu Val Pro Ala Val Leu Trp Gly 
1               5                   10                  15      


Leu Ser Leu Phe Leu Asn Leu Pro Gly Pro Ile Trp Leu Gln Pro Ser 
            20                  25                  30          


Pro Pro Pro Gln Ser Ser Pro Pro Pro Gln Pro His Pro Cys His Thr 
        35                  40                  45              


Cys Arg Gly Leu Val Asp Ser Phe Asn Lys Gly Leu Glu Arg Thr Ile 
    50                  55                  60                  


Arg Asp Asn Phe Gly Gly Gly Asn Thr Ala Trp Glu Glu Glu Asn Leu 
65                  70                  75                  80  


Ser Lys Tyr Lys Asp Ser Glu Thr Arg Leu Val Glu Val Leu Glu Gly 
                85                  90                  95      


Val Cys Ser Lys Ser Asp Phe Glu Cys His Arg Leu Leu Glu Leu Ser 
            100                 105                 110         


Glu Glu Leu Val Glu Ser Trp Trp Phe His Lys Gln Gln Glu Ala Pro 
        115                 120                 125             


Asp Leu Phe Gln Trp Leu Cys Ser Asp Ser Leu Lys Leu Cys Cys Pro 
    130                 135                 140                 


Ala Gly Thr Phe Gly Pro Ser Cys Leu Pro Cys Pro Gly Gly Thr Glu 
145                 150                 155                 160 


Arg Pro Cys Gly Gly Tyr Gly Gln Cys Glu Gly Glu Gly Thr Arg Gly 
                165                 170                 175     


Gly Ser Gly His Cys Asp Cys Gln Ala Gly Tyr Gly Gly Glu Ala Cys 
            180                 185                 190         


Gly Gln Cys Gly Leu Gly Tyr Phe Glu Ala Glu Arg Asn Ala Ser His 
        195                 200                 205             


Leu Val Cys Ser Ala Cys Phe Gly Pro Cys Ala Arg Cys Ser Gly Pro 
    210                 215                 220                 


Glu Glu Ser Asn Cys Leu Gln Cys Lys Lys Gly Trp Ala Leu His His 
225                 230                 235                 240 


Leu Lys Cys Val Asp Ile Asp Glu Cys Gly Thr Glu Gly Ala Asn Cys 
                245                 250                 255     


Gly Ala Asp Gln Phe Cys Val Asn Thr Glu Gly Ser Tyr Glu Cys Arg 
            260                 265                 270         


Asp Cys Ala Lys Ala Cys Leu Gly Cys Met Gly Ala Gly Pro Gly Arg 
        275                 280                 285             


Cys Lys Lys Cys Ser Pro Gly Tyr Gln Gln Val Gly Ser Lys Cys Leu 
    290                 295                 300                 


Asp Val Asp Glu Cys Glu Thr Glu Val Cys Pro Gly Glu Asn Lys Gln 
305                 310                 315                 320 


Cys Glu Asn Thr Glu Gly Gly Tyr Arg Cys Ile Cys Ala Glu Gly Tyr 
                325                 330                 335     


Lys Gln Met Glu Gly Ile Cys Val Lys Glu Gln Ile Pro Glu Ser Ala 
            340                 345                 350         


Gly Phe Phe Ser Glu Met Thr Glu Asp Glu Leu Val Val Leu Gln Gln 
        355                 360                 365             


Met Phe Phe Gly Ile Ile Ile Cys Ala Leu Ala Thr Leu Ala Ala Lys 
    370                 375                 380                 


Gly Asp Leu Val Phe Thr Ala Ile Phe Ile Gly Ala Val Ala Ala Met 
385                 390                 395                 400 


Thr Gly Tyr Trp Leu Ser Glu Arg Ser Asp Arg Val Leu Glu Gly Phe 
                405                 410                 415     


Ile Lys Gly Arg 
            420 


<210>  967
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  967

Met Ala Thr Arg Arg Ser Gln Thr Trp Ser Pro Gly Ser Arg Ser Ala 
1               5                   10                  15      


Cys Glu Arg Cys Ser Trp Arg Ser Met Ser Ser Ser Leu Thr Arg Ser 
            20                  25                  30          


Ser Ala Val Thr Ala Arg Gly Ser Ala Pro Lys Pro Arg Cys Ser Cys 
        35                  40                  45              


Cys Trp Pro Leu Arg Ser Arg Thr Ser Arg Arg Cys Trp Trp Pro Ser 
    50                  55                  60                  


Gly Ala Thr Val Ser Leu Pro Arg Pro Leu Cys His Glu Ala Pro Arg 
65                  70                  75                  80  


Ala Arg Ser Ala Arg Ala Gly Leu Pro Asn Arg Leu Pro Thr Ala Leu 
                85                  90                  95      


Phe Asn Ser Gly Phe Trp Leu Lys Arg Ser Ser Tyr Glu Glu Gln Pro 
            100                 105                 110         


Thr Val Arg Phe Gln His Gln Val Leu Leu Val Ala Leu Leu Gly Pro 
        115                 120                 125             


Glu Ser Asp Gly Phe Leu Ala Trp Ser Thr Phe Pro Ala Phe Asn Arg 
    130                 135                 140                 


Leu Gln Gly Asp Arg Leu Arg Val Pro Leu Val Ser Thr Arg Glu Glu 
145                 150                 155                 160 


Asp Arg Asn Gln Asp Gly Lys Thr Asp Met Leu His Phe Lys Leu Glu 
                165                 170                 175     


Leu Pro Leu Gln Ser Thr Glu His Val Leu Gly Val Gln Leu Ile Leu 
            180                 185                 190         


Thr Phe Ser Tyr Arg Leu His Arg Met Ala Thr Leu Val Met Gln Ser 
        195                 200                 205             


Met Ala Phe Leu Gln Ser Ser Phe Pro Val Pro Gly Ser Gln Leu Tyr 
    210                 215                 220                 


Val Asn Gly Asp Leu Arg Leu Gln Gln Lys Gln Pro Leu Ser Cys Gly 
225                 230                 235                 240 


Gly Leu Asp Ala Arg Tyr Asn Ile Ser Val Ile Asn Gly Thr Ser Pro 
                245                 250                 255     


Phe Ala Tyr Asp Tyr Asp Leu Thr His Ile Val Ala Ala Tyr Gln Glu 
            260                 265                 270         


Arg Asn Val Thr Thr Val Leu Asn Asp Pro Asn Pro Ile Trp Leu Val 
        275                 280                 285             


Gly Arg Ala Ala Asp Ala Pro Phe Val Ile Asn Ala Ile Ile Arg Tyr 
    290                 295                 300                 


Pro Val Glu Val Ile Ser Tyr Gln Pro Gly Phe Trp Glu Met Val Lys 
305                 310                 315                 320 


Phe Ala Trp Val Gln Tyr Val Ser Ile Leu Leu Ile Phe Leu Trp Val 
                325                 330                 335     


Phe Glu Arg Ile Lys Ile Phe Val Phe Gln Asn Gln Val Val Thr Thr 
            340                 345                 350         


Ile Pro Val Thr Val Thr Pro Arg Gly Asp Leu Cys Lys Glu His Leu 
        355                 360                 365             


Ser 
    


<210>  968
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  968

Met Ala Leu Tyr Glu Leu Phe Ser His Pro Val Glu Arg Ser Tyr Arg 
1               5                   10                  15      


Ala Gly Leu Cys Ser Lys Ala Ala Leu Phe Leu Leu Leu Ala Ala Ala 
            20                  25                  30          


Leu Thr Tyr Ile Pro Pro Leu Leu Val Ala Phe Arg Ser His Gly Phe 
        35                  40                  45              


Trp Leu Lys Arg Ser Ser Tyr Glu Glu Gln Pro Thr Val Arg Phe Gln 
    50                  55                  60                  


His Gln Val Leu Leu Val Ala Leu Leu Gly Pro Glu Ser Asp Gly Phe 
65                  70                  75                  80  


Leu Ala Trp Ser Thr Phe Pro Ala Phe Asn Arg Leu Gln Gly Asp Arg 
                85                  90                  95      


Leu Arg Val Pro Leu Val Ser Thr Arg Glu Glu Asp Arg Asn Gln Asp 
            100                 105                 110         


Gly Lys Thr Asp Met Leu His Phe Lys Leu Glu Leu Pro Leu Gln Ser 
        115                 120                 125             


Thr Glu His Val Leu Gly Val Gln Leu Ile Leu Thr Phe Ser Tyr Arg 
    130                 135                 140                 


Leu His Arg Met Ala Thr Leu Val Met Gln Ser Met Ala Phe Leu Gln 
145                 150                 155                 160 


Ser Ser Phe Pro Val Pro Gly Ser Gln Leu Tyr Val Asn Gly Asp Leu 
                165                 170                 175     


Arg Leu Gln Gln Lys Gln Pro Leu Ser Cys Gly Gly Leu Asp Ala Arg 
            180                 185                 190         


Tyr Asn Ile Ser Val Ile Asn Gly Thr Ser Pro Phe Ala Tyr Asp Tyr 
        195                 200                 205             


Asp Leu Thr His Ile Val Ala Ala Tyr Gln Glu Arg Asn Val Thr Thr 
    210                 215                 220                 


Val Leu Asn Asp Pro Asn Pro Ile Trp Leu Val Gly Arg Ala Ala Asp 
225                 230                 235                 240 


Ala Pro Phe Val Ile Asn Ala Ile Ile Arg Tyr Pro Val Glu Val Ile 
                245                 250                 255     


Ser Tyr Gln Pro Gly Phe Trp Glu Met Val Lys Phe Ala Trp Val Gln 
            260                 265                 270         


Tyr Val Ser Ile Leu Leu Ile Phe Leu Trp Val Phe Glu Arg Ile Lys 
        275                 280                 285             


Ile Phe Val Phe Gln Asn Gln Val Val Thr Thr Ile Pro Val Thr Val 
    290                 295                 300                 


Thr Pro Arg Gly Asp Leu Cys Lys Glu His Leu Ser 
305                 310                 315     


<210>  969
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  969

Met Ala Thr Arg Arg Ser Gln Thr Trp Ser Pro Gly Ser Arg Ser Ala 
1               5                   10                  15      


Cys Glu Arg Cys Ser Trp Arg Ser Met Ser Ser Ser Leu Thr Arg Ser 
            20                  25                  30          


Ser Ala Val Thr Ala Arg Gly Ser Ala Pro Lys Pro Arg Cys Ser Cys 
        35                  40                  45              


Cys Trp Pro Leu Arg Ser Arg Thr Ser Arg Arg Cys Trp Trp Pro Ser 
    50                  55                  60                  


Gly Ala Thr Val Ser Leu Pro Arg Pro Leu Cys His Glu Ala Pro Arg 
65                  70                  75                  80  


Ala Arg Ser Ala Arg Ala Gly Leu Pro Asn Arg Leu Pro Thr Ala Leu 
                85                  90                  95      


Phe Asn Ser Gly Phe Trp Leu Lys Arg Ser Ser Tyr Glu Glu Gln Pro 
            100                 105                 110         


Thr Val Arg Phe Gln His Gln Val Leu Leu Val Ala Leu Leu Gly Pro 
        115                 120                 125             


Glu Ser Asp Gly Phe Leu Ala Trp Ser Thr Phe Pro Ala Phe Asn Arg 
    130                 135                 140                 


Leu Gln Gly Asp Arg Leu Arg Val Pro Leu Val Ser Thr Arg Glu Glu 
145                 150                 155                 160 


Asp Arg Asn Gln Asp Gly Lys Thr Asp Met Leu His Phe Lys Leu Glu 
                165                 170                 175     


Leu Pro Leu Gln Ser Thr Glu His Val Leu Gly Val Gln Leu Ile Leu 
            180                 185                 190         


Thr Phe Ser Tyr Arg Leu His Arg Met Ala Thr Leu Val Met Gln Ser 
        195                 200                 205             


Met Ala Phe Leu Gln Ser Ser Phe Pro Val Pro Gly Ser Gln Leu Tyr 
    210                 215                 220                 


Val Asn Gly Asp Leu Arg Leu Gln Gln Lys Gln Pro Leu Ser Cys Gly 
225                 230                 235                 240 


Gly Leu Asp Ala Arg Tyr Asn Ile Ser Val Ile Asn Gly Thr Ser Pro 
                245                 250                 255     


Phe Ala Tyr Asp Tyr Asp Leu Thr His Ile Val Ala Ala Tyr Gln Glu 
            260                 265                 270         


Arg Asn Val Thr Thr Val Leu Asn Asp Pro Asn Pro Ile Trp Leu Val 
        275                 280                 285             


Gly Arg Ala Ala Asp Ala Pro Phe Val Ile Asn Ala Ile Ile Arg Tyr 
    290                 295                 300                 


Pro Val Glu Val Ile Ser Tyr Gln Pro Gly Phe Trp Glu Met Val Lys 
305                 310                 315                 320 


Phe Ala Trp Val Gln Tyr Val Ser Ile Leu Leu Ile Phe Leu Trp Val 
                325                 330                 335     


Phe Glu Arg Ile Lys Ile Phe Val Phe Gln Asn Gln Val Val Thr Thr 
            340                 345                 350         


Ile Pro Val Thr Val Thr Pro Arg Gly Asp Leu Cys Lys Glu His Leu 
        355                 360                 365             


Ser 
    


<210>  970
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  970

Met Cys Gln Lys Glu Val Met Glu Gln Ser Ala Gly Ile Met Tyr Arg 
1               5                   10                  15      


Lys Ser Cys Ala Ser Ser Ala Ala Cys Leu Ile Ala Ser Ala Gly Tyr 
            20                  25                  30          


Gln Ser Phe Cys Ser Pro Gly Lys Leu Asn Ser Val Cys Ile Ser Cys 
        35                  40                  45              


Cys Asn Thr Pro Leu Cys Asn Gly Pro Arg Pro Lys Lys Arg Gly Ser 
    50                  55                  60                  


Ser Ala Ser Ala Leu Arg Pro Gly Leu Arg Thr Thr Ile Leu Phe Leu 
65                  70                  75                  80  


Lys Leu Ala Leu Phe Ser Ala His Cys 
                85                  


<210>  971
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  971

Met Ala Thr Ala Arg Pro Pro Trp Met Trp Val Leu Cys Ala Leu Ile 
1               5                   10                  15      


Thr Ala Leu Leu Leu Gly Val Thr Glu His Val Leu Ala Asn Asn Asp 
            20                  25                  30          


Val Ser Cys Asp His Pro Ser Asn Thr Val Pro Ser Gly Ser Asn Gln 
        35                  40                  45              


Asp Leu Gly Ala Gly Ala Gly Glu Asp Ala Arg Ser Asp Asp Ser Ser 
    50                  55                  60                  


Ser Arg Ile Ile Asn Gly Ser Asp Cys Asp Met His Thr Gln Pro Trp 
65                  70                  75                  80  


Gln Ala Ala Leu Leu Leu Arg Pro Asn Gln Leu Tyr Cys Gly Ala Val 
                85                  90                  95      


Leu Val His Pro Gln Trp Leu Leu Thr Ala Ala His Cys Arg Lys Lys 
            100                 105                 110         


Val Phe Arg Val Arg Leu Gly His Tyr Ser Leu Ser Pro Val Tyr Glu 
        115                 120                 125             


Ser Gly Gln Gln Met Phe Gln Gly Val Lys Ser Ile Pro His Pro Gly 
    130                 135                 140                 


Tyr Ser His Pro Gly His Ser Asn Asp Leu Met Leu Ile Lys Leu Asn 
145                 150                 155                 160 


Arg Arg Ile Arg Pro Thr Lys Asp Val Arg Pro Ile Asn Val Ser Ser 
                165                 170                 175     


His Cys Pro Ser Ala Gly Thr Lys Cys Leu Val Ser Gly Trp Gly Thr 
            180                 185                 190         


Thr Lys Ser Pro Gln Val His Phe Pro Lys Val Leu Gln Cys Leu Asn 
        195                 200                 205             


Ile Ser Val Leu Ser Gln Lys Arg Cys Glu Asp Ala Tyr Pro Arg Gln 
    210                 215                 220                 


Ile Asp Asp Thr Met Phe Cys Ala Gly Asp Lys Ala Gly Arg Asp Ser 
225                 230                 235                 240 


Cys Gln Gly Asp Ser Gly Gly Pro Val Val Cys Asn Gly Ser Leu Gln 
                245                 250                 255     


Gly Leu Val Ser Trp Gly Asp Tyr Pro Cys Ala Arg Pro Asn Arg Pro 
            260                 265                 270         


Gly Val Tyr Thr Asn Leu Cys Lys Phe Thr Lys Trp Ile Gln Glu Thr 
        275                 280                 285             


Ile Gln Ala Asn Ser 
    290             


<210>  972
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  972

Met Ala Thr Ala Arg Pro Pro Trp Met Trp Val Leu Cys Ala Leu Ile 
1               5                   10                  15      


Thr Ala Leu Leu Leu Gly Val Thr Glu His Val Leu Ala Asn Asn Asp 
            20                  25                  30          


Val Ser Cys Asp His Pro Ser Asn Thr Val Pro Ser Gly Ser Asn Gln 
        35                  40                  45              


Asp Leu Gly Ala Gly Ala Gly Glu Asp Ala Arg Ser Asp Asp Ser Ser 
    50                  55                  60                  


Ser Arg Ile Ile Asn Gly Ser Asp Cys Asp Met His Thr Gln Pro Trp 
65                  70                  75                  80  


Gln Ala Ala Leu Leu Leu Arg Pro Asn Gln Leu Tyr Cys Gly Ala Val 
                85                  90                  95      


Leu Val His Pro Gln Trp Leu Leu Thr Ala Ala His Cys Arg Lys Lys 
            100                 105                 110         


Val Phe Arg Val Arg Leu Gly His Tyr Ser Leu Ser Pro Val Tyr Glu 
        115                 120                 125             


Ser Gly Gln Gln Met Phe Gln Gly Val Lys Ser Ile Pro His Pro Gly 
    130                 135                 140                 


Tyr Ser His Pro Gly His Ser Asn Asp Leu Met Leu Ile Lys Leu Asn 
145                 150                 155                 160 


Arg Arg Ile Arg Pro Thr Lys Asp Val Arg Pro Ile Asn Val Ser Ser 
                165                 170                 175     


His Cys Pro Ser Ala Gly Thr Lys Cys Leu Val Ser Gly Trp Gly Thr 
            180                 185                 190         


Thr Lys Ser Pro Gln Val His Phe Pro Lys Val Leu Gln Cys Leu Asn 
        195                 200                 205             


Ile Ser Val Leu Ser Gln Lys Arg Cys Glu Asp Ala Tyr Pro Arg Gln 
    210                 215                 220                 


Ile Asp Asp Thr Met Phe Cys Ala Gly Asp Lys Ala Gly Arg Asp Ser 
225                 230                 235                 240 


Cys Gln Gly Asp Ser Gly Gly Pro Val Val Cys Asn Gly Ser Leu Gln 
                245                 250                 255     


Gly Leu Val Ser Trp Gly Asp Tyr Pro Cys Ala Arg Pro Asn Arg Pro 
            260                 265                 270         


Gly Val Tyr Thr Asn Leu Cys Lys Phe Thr Lys Trp Ile Gln Glu Thr 
        275                 280                 285             


Ile Gln Ala Asn Ser 
    290             


<210>  973
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  973

Met Ala Arg Gly Leu Gly Ala Pro His Trp Val Ala Val Gly Leu Leu 
1               5                   10                  15      


Thr Trp Ala Thr Leu Gly Leu Leu Val Ala Gly Leu Gly Gly His Asp 
            20                  25                  30          


Asp Leu His Asp Asp Leu Gln Glu Asp Phe His Gly His Ser His Arg 
        35                  40                  45              


His Ser His Glu Asp Phe His His Gly His Ser His Ala His Gly His 
    50                  55                  60                  


Gly His Thr His Glu Ser Ile Trp His Gly His Thr His Asp His Asp 
65                  70                  75                  80  


His Gly His Ser His Glu Asp Leu His His Gly His Ser His Gly Tyr 
                85                  90                  95      


Ser His Glu Ser Leu Tyr His Arg Gly His Gly His Asp His Glu His 
            100                 105                 110         


Ser His Gly Gly Tyr Gly Glu Ser Gly Ala Pro Gly Ile Lys Gln Asp 
        115                 120                 125             


Leu Asp Ala Val Thr Leu Trp Ala Tyr Ala Leu Gly Ala Thr Val Leu 
    130                 135                 140                 


Ile Ser Ala Ala Pro Phe Phe Val Leu Phe Leu Ile Pro Val Glu Ser 
145                 150                 155                 160 


Asn Ser Pro Arg His Arg Ser Leu Leu Gln Ile Leu Leu Ser Phe Ala 
                165                 170                 175     


Ser Gly Gly Leu Leu Gly Asp Ala Phe Leu His Leu Ile Pro His Ala 
            180                 185                 190         


Leu Glu Pro His Ser His His Thr Leu Glu Gln Pro Gly His Gly His 
        195                 200                 205             


Ser His Ser Gly Gln Gly Pro Ile Leu Ser Val Gly Leu Trp Val Leu 
    210                 215                 220                 


Ser Gly Ile Val Ala Phe Leu Val Val Glu Lys Phe Val Arg His Val 
225                 230                 235                 240 


Lys Gly Gly His Gly His Ser His Gly His Gly His Ala His Ser His 
                245                 250                 255     


Thr Arg Gly Ser His Gly His Gly Arg Gln Glu Arg Ser Thr Lys Glu 
            260                 265                 270         


Lys Gln Ser Ser Glu Glu Glu Glu Lys Glu Thr Arg Gly Val Gln Lys 
        275                 280                 285             


Arg Arg Gly Gly Ser Thr Val Pro Lys Asp Gly Pro Val Arg Pro Gln 
    290                 295                 300                 


Asn Ala Glu Glu Glu Lys Arg Gly Leu Asp Leu Arg Val Ser Gly Tyr 
305                 310                 315                 320 


Leu Asn Leu Ala Ala Asp Leu Ala His Asn Phe Thr Asp Gly Leu Ala 
                325                 330                 335     


Ile Gly Ala Ser Phe Arg Gly Gly Arg Gly Leu Gly Ile Leu Thr Thr 
            340                 345                 350         


Met Thr Val Leu Leu His Glu Val Pro His Glu Val Gly Asp Phe Ala 
        355                 360                 365             


Ile Leu Val Gln Ser Gly Cys Ser Lys Lys Gln Ala Met Arg Leu Gln 
    370                 375                 380                 


Leu Leu Thr Ala Val Gly Ala Leu Ala Gly Thr Ala Cys Ala Leu Leu 
385                 390                 395                 400 


Thr Glu Gly Gly Ala Val Gly Ser Glu Ile Ala Gly Gly Ala Gly Pro 
                405                 410                 415     


Gly Trp Val Leu Pro Phe Thr Ala Gly Gly Phe Ile Tyr Val Ala Thr 
            420                 425                 430         


Val Ser Val Leu Pro Glu Leu Leu Arg Glu Ala Ser Pro Leu Gln Ser 
        435                 440                 445             


Leu Leu Glu Val Leu Gly Leu Leu Gly Gly Val Ile Met Met Val Leu 
    450                 455                 460                 


Ile Ala His Leu Glu 
465                 


<210>  974
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  974

Met Gly Ala Ala Val Phe Phe Gly Cys Thr Phe Val Ala Phe Gly Pro 
1               5                   10                  15      


Ala Phe Ala Leu Phe Leu Ile Thr Val Ala Gly Asp Pro Leu Arg Val 
            20                  25                  30          


Ile Ile Leu Val Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Leu 
        35                  40                  45              


Ala Ser Val Val Trp Phe Ile Leu Val His Val Thr Asp Arg Ser Asp 
    50                  55                  60                  


Ala Arg Leu Gln Tyr Gly Leu Leu Ile Phe Gly Ala Ala Val Ser Val 
65                  70                  75                  80  


Leu Leu Gln Glu Val Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Asp Glu Gly Leu Ala Ser Leu Ser Glu Asp Gly Arg Ser Pro Ile 
            100                 105                 110         


Ser Ile Arg Gln Met Ala Tyr Val Ser Gly Leu Ser Phe Gly Ile Ile 
        115                 120                 125             


Ser Gly Val Phe Ser Val Ile Asn Ile Leu Ala Asp Ala Leu Gly Pro 
    130                 135                 140                 


Gly Val Val Gly Ile His Gly Asp Ser Pro Tyr Tyr Phe Leu Thr Ser 
145                 150                 155                 160 


Ala Phe Leu Thr Ala Ala Ile Ile Leu Leu His Thr Phe Trp Gly Val 
                165                 170                 175     


Val Phe Phe Asp Ala Cys Glu Arg Arg Arg Tyr Trp Ala Leu Gly Leu 
            180                 185                 190         


Val Val Gly Ser His Leu Leu Thr Ser Gly Leu Thr Phe Leu Asn Pro 
        195                 200                 205             


Trp Tyr Glu Ala Ser Leu Leu Pro Ile Tyr Ala Val Thr Val Ser Met 
    210                 215                 220                 


Gly Leu Trp Ala Phe Ile Thr Ala Gly Gly Ser Leu Arg Ser Ile Gln 
225                 230                 235                 240 


Arg Ser Leu Leu Cys Arg Arg Gln Glu Asp Ser Arg Val Met Val Tyr 
                245                 250                 255     


Ser Ala Leu Arg Ile Pro Pro Glu Asp 
            260                 265 


<210>  975
<211>  544
<212>  PRT
<213>  Homo sapiens

<400>  975

Met Lys Ile Ser Met Ile Asn Tyr Lys Ser Leu Leu Ala Leu Leu Phe 
1               5                   10                  15      


Ile Leu Ala Ser Trp Ile Ile Phe Thr Val Phe Gln Asn Ser Thr Lys 
            20                  25                  30          


Val Trp Ser Ala Leu Asn Leu Ser Ile Ser Leu His Tyr Trp Asn Asn 
        35                  40                  45              


Ser Thr Lys Ser Leu Phe Pro Lys Thr Pro Leu Ile Ser Leu Lys Pro 
    50                  55                  60                  


Leu Thr Glu Thr Glu Leu Arg Ile Lys Glu Ile Ile Glu Lys Leu Asp 
65                  70                  75                  80  


Gln Gln Ile Pro Pro Arg Pro Phe Thr His Val Asn Thr Thr Thr Ser 
                85                  90                  95      


Ala Thr His Ser Thr Ala Thr Ile Leu Asn Pro Arg Asp Thr Tyr Cys 
            100                 105                 110         


Arg Gly Asp Gln Leu His Ile Leu Leu Glu Val Arg Asp His Leu Gly 
        115                 120                 125             


Arg Arg Lys Gln Tyr Gly Gly Asp Phe Leu Arg Ala Arg Met Ser Ser 
    130                 135                 140                 


Pro Ala Leu Met Ala Gly Ala Ser Gly Lys Val Thr Asp Phe Asn Asn 
145                 150                 155                 160 


Gly Thr Tyr Leu Val Ser Phe Thr Leu Phe Trp Glu Gly Gln Val Ser 
                165                 170                 175     


Leu Ser Leu Leu Leu Ile His Pro Ser Glu Gly Val Ser Ala Leu Trp 
            180                 185                 190         


Ser Ala Arg Asn Gln Gly Tyr Asp Arg Val Ile Phe Thr Gly Gln Phe 
        195                 200                 205             


Val Asn Gly Thr Ser Gln Val His Ser Glu Cys Gly Leu Ile Leu Asn 
    210                 215                 220                 


Thr Asn Ala Glu Leu Cys Gln Tyr Leu Asp Asn Arg Asp Gln Glu Gly 
225                 230                 235                 240 


Phe Tyr Cys Val Arg Pro Gln His Met Pro Cys Ala Ala Leu Thr His 
                245                 250                 255     


Met Tyr Ser Lys Asn Lys Lys Val Ser Tyr Leu Ser Lys Gln Glu Lys 
            260                 265                 270         


Ser Leu Phe Glu Arg Ser Asn Val Gly Val Glu Ile Met Glu Lys Phe 
        275                 280                 285             


Asn Thr Ile Ser Val Ser Lys Cys Asn Lys Glu Thr Val Ala Met Lys 
    290                 295                 300                 


Glu Lys Cys Lys Phe Gly Met Thr Ser Thr Ile Pro Ser Gly His Val 
305                 310                 315                 320 


Trp Arg Asn Thr Trp Asn Pro Val Ser Cys Ser Leu Ala Thr Val Lys 
                325                 330                 335     


Met Lys Glu Cys Leu Arg Gly Lys Leu Ile Tyr Leu Met Gly Asp Ser 
            340                 345                 350         


Thr Ile Arg Gln Trp Met Glu Tyr Phe Lys Ala Ser Ile Asn Thr Leu 
        355                 360                 365             


Lys Ser Val Asp Leu His Glu Ser Gly Lys Leu Gln His Gln Leu Ala 
    370                 375                 380                 


Val Asp Leu Asp Arg Asn Ile Asn Ile Gln Trp Gln Lys Tyr Cys Tyr 
385                 390                 395                 400 


Pro Leu Ile Gly Ser Met Thr Tyr Ser Val Lys Glu Met Glu Tyr Leu 
                405                 410                 415     


Thr Arg Ala Ile Asp Arg Thr Gly Gly Glu Lys Asn Thr Val Ile Val 
            420                 425                 430         


Ile Ser Leu Gly Gln His Phe Arg Pro Phe Pro Ile Asp Val Phe Ile 
        435                 440                 445             


Arg Arg Ala Leu Asn Val His Lys Ala Ile Gln His Leu Leu Leu Arg 
    450                 455                 460                 


Ser Pro Asp Thr Met Val Ile Ile Lys Thr Glu Asn Ile Arg Glu Met 
465                 470                 475                 480 


Tyr Asn Asp Ala Glu Arg Phe Ser Asp Phe His Gly Tyr Ile Gln Tyr 
                485                 490                 495     


Leu Ile Ile Lys Asp Ile Phe Gln Asp Leu Ser Val Ser Ile Ile Asp 
            500                 505                 510         


Ala Trp Asp Ile Thr Ile Ala Tyr Gly Thr Asn Asn Val His Pro Pro 
        515                 520                 525             


Gln His Val Val Gly Asn Gln Ile Asn Ile Leu Leu Asn Tyr Ile Cys 
    530                 535                 540                 


<210>  976
<211>  611
<212>  PRT
<213>  Homo sapiens

<400>  976

Met Ala Ser Arg Gly Ala Arg Gln Arg Leu Lys Gly Ser Gly Ala Ser 
1               5                   10                  15      


Ser Gly Asp Thr Ala Pro Ala Ala Asp Lys Leu Arg Glu Leu Leu Gly 
            20                  25                  30          


Ser Arg Glu Ala Gly Gly Ala Glu His Arg Thr Glu Leu Ser Gly Asn 
        35                  40                  45              


Lys Ala Gly Gln Val Trp Ala Pro Glu Gly Ser Thr Ala Phe Lys Cys 
    50                  55                  60                  


Leu Leu Ser Ala Arg Leu Cys Ala Ala Leu Leu Ser Asn Ile Ser Asp 
65                  70                  75                  80  


Cys Asp Glu Thr Phe Asn Tyr Trp Glu Pro Thr His Tyr Leu Ile Tyr 
                85                  90                  95      


Gly Glu Gly Phe Gln Thr Trp Glu Tyr Ser Pro Ala Tyr Ala Ile Arg 
            100                 105                 110         


Ser Tyr Ala Tyr Leu Leu Leu His Ala Trp Pro Ala Ala Phe His Ala 
        115                 120                 125             


Arg Ile Leu Gln Thr Asn Lys Ile Leu Val Phe Tyr Phe Leu Arg Cys 
    130                 135                 140                 


Leu Leu Ala Phe Val Ser Cys Ile Cys Glu Leu Tyr Phe Tyr Lys Ala 
145                 150                 155                 160 


Val Cys Lys Lys Phe Gly Leu His Val Ser Arg Met Met Leu Ala Phe 
                165                 170                 175     


Leu Val Leu Ser Thr Gly Met Phe Cys Ser Ser Ser Ala Phe Leu Pro 
            180                 185                 190         


Ser Ser Phe Cys Met Tyr Thr Thr Leu Ile Ala Met Thr Gly Trp Tyr 
        195                 200                 205             


Met Asp Lys Thr Ser Ile Ala Val Leu Gly Val Ala Ala Gly Ala Ile 
    210                 215                 220                 


Leu Gly Trp Pro Phe Ser Ala Ala Leu Gly Leu Pro Ile Ala Phe Asp 
225                 230                 235                 240 


Leu Leu Val Met Lys His Arg Trp Lys Ser Phe Phe His Trp Ser Leu 
                245                 250                 255     


Met Ala Leu Ile Leu Phe Leu Val Pro Val Val Val Ile Asp Ser Tyr 
            260                 265                 270         


Tyr Tyr Gly Lys Leu Val Ile Ala Pro Leu Asn Ile Val Leu Tyr Asn 
        275                 280                 285             


Val Phe Thr Pro His Gly Pro Asp Leu Tyr Gly Thr Glu Pro Trp Tyr 
    290                 295                 300                 


Phe Tyr Leu Ile Asn Gly Phe Leu Asn Phe Asn Val Ala Phe Ala Leu 
305                 310                 315                 320 


Ala Leu Leu Val Leu Pro Leu Thr Ser Leu Met Glu Tyr Leu Leu Gln 
                325                 330                 335     


Arg Phe His Val Gln Asn Leu Gly His Pro Tyr Trp Leu Thr Leu Ala 
            340                 345                 350         


Pro Met Tyr Ile Trp Phe Ile Ile Phe Phe Ile Gln Pro His Lys Glu 
        355                 360                 365             


Glu Arg Phe Leu Phe Pro Val Tyr Pro Leu Ile Cys Leu Cys Gly Ala 
    370                 375                 380                 


Val Ala Leu Ser Ala Leu Gln Lys Cys Tyr His Phe Val Phe Gln Arg 
385                 390                 395                 400 


Tyr Arg Leu Glu His Tyr Thr Val Thr Ser Asn Trp Leu Ala Leu Gly 
                405                 410                 415     


Thr Val Phe Leu Phe Gly Leu Leu Ser Phe Ser Arg Ser Val Ala Leu 
            420                 425                 430         


Phe Arg Gly Tyr His Gly Pro Leu Asp Leu Tyr Pro Glu Phe Tyr Arg 
        435                 440                 445             


Ile Ala Thr Asp Pro Thr Ile His Thr Val Pro Glu Gly Arg Pro Val 
    450                 455                 460                 


Asn Val Cys Val Gly Lys Glu Trp Tyr Arg Phe Pro Ser Ser Phe Leu 
465                 470                 475                 480 


Leu Pro Asp Asn Trp Gln Leu Gln Phe Ile Pro Ser Glu Phe Arg Gly 
                485                 490                 495     


Gln Leu Pro Lys Pro Phe Ala Glu Gly Pro Leu Ala Thr Arg Ile Val 
            500                 505                 510         


Pro Thr Asp Met Asn Asp Gln Asn Leu Glu Glu Pro Ser Arg Tyr Ile 
        515                 520                 525             


Asp Ile Ser Lys Cys His Tyr Leu Val Asp Leu Asp Thr Met Arg Glu 
    530                 535                 540                 


Thr Pro Arg Glu Pro Lys Tyr Ser Ser Asn Lys Glu Glu Trp Ile Ser 
545                 550                 555                 560 


Leu Ala Tyr Arg Pro Phe Leu Asp Ala Ser Arg Ser Ser Lys Leu Leu 
                565                 570                 575     


Arg Ala Phe Tyr Val Pro Phe Leu Ser Asp Gln Tyr Thr Val Tyr Val 
            580                 585                 590         


Asn Tyr Thr Ile Leu Lys Pro Arg Lys Ala Lys Gln Ile Arg Lys Lys 
        595                 600                 605             


Ser Gly Gly 
    610     


<210>  977
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  977

Met Met Leu Ala Phe Leu Val Leu Ser Thr Gly Met Phe Cys Ser Ser 
1               5                   10                  15      


Ser Ala Phe Leu Pro Ser Ser Phe Cys Met Tyr Thr Thr Leu Ile Ala 
            20                  25                  30          


Met Thr Gly Trp Tyr Met Asp Lys Thr Ser Ile Ala Val Leu Gly Val 
        35                  40                  45              


Ala Ala Gly Ala Ile Leu Gly Trp Pro Phe Ser Ala Ala Leu Gly Leu 
    50                  55                  60                  


Pro Ile Ala Phe Asp Leu Leu Val Met Lys His Arg Trp Lys Ser Phe 
65                  70                  75                  80  


Phe His Trp Ser Leu Met Ala Leu Ile Leu Phe Leu Val Pro Val Val 
                85                  90                  95      


Val Ile Asp Ser Tyr Tyr Tyr Gly Lys Leu Val Ile Ala Pro Leu Asn 
            100                 105                 110         


Ile Val Leu Tyr Asn Val Phe Thr Pro His Gly Pro Asp Leu Tyr Gly 
        115                 120                 125             


Thr Glu Pro Trp Tyr Phe Tyr Leu Ile Asn Gly Phe Leu Asn Phe Asn 
    130                 135                 140                 


Val Ala Phe Ala Leu Ala Leu Leu Val Leu Pro Leu Thr Ser Leu Met 
145                 150                 155                 160 


Glu Tyr Leu Leu Gln Arg Phe His Val Gln Asn Leu Gly His Pro Tyr 
                165                 170                 175     


Trp Leu Thr Leu Ala Pro Met Tyr Ile Trp Phe Ile Ile Phe Phe Ile 
            180                 185                 190         


Gln Pro His Lys Glu Glu Arg Phe Leu Phe Pro Val Tyr Pro Leu Ile 
        195                 200                 205             


Cys Leu Cys Gly Ala Val Ala Leu Ser Ala Leu Gln His Ser Phe Leu 
    210                 215                 220                 


Tyr Phe Gln Lys Cys Tyr His Phe Val Phe Gln Arg Tyr Arg Leu Glu 
225                 230                 235                 240 


His Tyr Thr Val Thr Ser Asn Trp Leu Ala Leu Gly Thr Val Phe Leu 
                245                 250                 255     


Phe Gly Leu Leu Ser Phe Ser Arg Ser Val Ala Leu Phe Arg Gly Tyr 
            260                 265                 270         


His Gly Pro Leu Asp Leu Tyr Pro Glu Phe Tyr Arg Ile Ala Thr Asp 
        275                 280                 285             


Pro Thr Ile His Thr Val Pro Glu Gly Arg Pro Val Asn Val Cys Val 
    290                 295                 300                 


Gly Lys Glu Trp Tyr Arg Phe Pro Ser Ser Phe Leu Leu Pro Asp Asn 
305                 310                 315                 320 


Trp Gln Leu Gln Phe Ile Pro Ser Glu Phe Arg Gly Gln Leu Pro Lys 
                325                 330                 335     


Pro Phe Ala Glu Gly Pro Leu Ala Thr Arg Ile Val Pro Thr Asp Met 
            340                 345                 350         


Asn Asp Gln Asn Leu Glu Glu Pro Ser Arg Tyr Ile Asp Ile Ser Lys 
        355                 360                 365             


Cys His Tyr Leu Val Asp Leu Asp Thr Met Arg Glu Thr Pro Arg Glu 
    370                 375                 380                 


Pro Lys Tyr Ser Ser Asn Lys Glu Glu Trp Ile Ser Leu Ala Tyr Arg 
385                 390                 395                 400 


Pro Phe Leu Asp Ala Ser Arg Ser Ser Lys Leu Leu Arg Ala Phe Tyr 
                405                 410                 415     


Val Pro Phe Leu Ser Asp Gln Tyr Thr Val Tyr Val Asn Tyr Thr Ile 
            420                 425                 430         


Leu Lys Pro Arg Lys Ala Lys Gln Ile Arg Lys Lys Ser Gly Gly 
        435                 440                 445         


<210>  978
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  978

Met Met Leu Ala Phe Leu Val Leu Ser Thr Gly Met Phe Cys Ser Ser 
1               5                   10                  15      


Ser Ala Phe Leu Pro Ser Ser Phe Cys Met Tyr Thr Thr Leu Ile Ala 
            20                  25                  30          


Met Thr Gly Trp Tyr Met Asp Lys Thr Ser Ile Ala Val Leu Gly Val 
        35                  40                  45              


Ala Ala Gly Ala Ile Leu Gly Trp Pro Phe Ser Ala Ala Leu Gly Leu 
    50                  55                  60                  


Pro Ile Ala Phe Asp Leu Leu Val Met Lys His Arg Trp Lys Ser Phe 
65                  70                  75                  80  


Phe His Trp Ser Leu Met Ala Leu Ile Leu Phe Leu Val Pro Val Val 
                85                  90                  95      


Val Ile Asp Ser Tyr Tyr Tyr Gly Lys Leu Val Ile Ala Pro Leu Asn 
            100                 105                 110         


Ile Val Leu Tyr Asn Val Phe Thr Pro His Gly Pro Asp Leu Tyr Gly 
        115                 120                 125             


Thr Glu Pro Trp Tyr Phe Tyr Leu Ile Asn Gly Phe Leu Asn Phe Asn 
    130                 135                 140                 


Val Ala Phe Ala Leu Ala Leu Leu Val Leu Pro Leu Thr Ser Leu Met 
145                 150                 155                 160 


Glu Tyr Leu Leu Gln Arg Phe His Val Gln Asn Leu Gly His Pro Tyr 
                165                 170                 175     


Trp Leu Thr Leu Ala Pro Met Tyr Ile Trp Phe Ile Ile Phe Phe Ile 
            180                 185                 190         


Gln Pro His Lys Glu Glu Arg Phe Leu Phe Pro Val Tyr Pro Leu Ile 
        195                 200                 205             


Cys Leu Cys Gly Ala Val Ala Leu Ser Ala Leu Gln Lys Cys Tyr His 
    210                 215                 220                 


Phe Val Phe Gln Arg Tyr Arg Leu Glu His Tyr Thr Val Thr Ser Asn 
225                 230                 235                 240 


Trp Leu Ala Leu Gly Thr Val Phe Leu Phe Gly Leu Leu Ser Phe Ser 
                245                 250                 255     


Arg Ser Val Ala Leu Phe Arg Gly Tyr His Gly Pro Leu Asp Leu Tyr 
            260                 265                 270         


Pro Glu Phe Tyr Arg Ile Ala Thr Asp Pro Thr Ile His Thr Val Pro 
        275                 280                 285             


Glu Gly Arg Pro Val Asn Val Cys Val Gly Lys Glu Trp Tyr Arg Phe 
    290                 295                 300                 


Pro Ser Ser Phe Leu Leu Pro Asp Asn Trp Gln Leu Gln Phe Ile Pro 
305                 310                 315                 320 


Ser Glu Phe Arg Gly Gln Leu Pro Lys Pro Phe Ala Glu Gly Pro Leu 
                325                 330                 335     


Ala Thr Arg Ile Val Pro Thr Asp Met Asn Asp Gln Asn Leu Glu Glu 
            340                 345                 350         


Pro Ser Arg Tyr Ile Asp Ile Ser Lys Cys His Tyr Leu Val Asp Leu 
        355                 360                 365             


Asp Thr Met Arg Glu Thr Pro Arg Glu Pro Lys Tyr Ser Ser Asn Lys 
    370                 375                 380                 


Glu Glu Trp Ile Ser Leu Ala Tyr Arg Pro Phe Leu Asp Ala Ser Arg 
385                 390                 395                 400 


Ser Ser Lys Leu Leu Arg Ala Phe Tyr Val Pro Phe Leu Ser Asp Gln 
                405                 410                 415     


Tyr Thr Val Tyr Val Asn Tyr Thr Ile Leu Lys Pro Arg Lys Ala Lys 
            420                 425                 430         


Gln Ile Arg Lys Lys Ser Gly Gly 
        435                 440 


<210>  979
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  979

Met Gly Thr Ala Gly Ala Met Gln Leu Cys Trp Val Ile Leu Gly Phe 
1               5                   10                  15      


Leu Leu Phe Arg Gly His Asn Ser Gln Pro Thr Met Thr Gln Thr Ser 
            20                  25                  30          


Ser Ser Gln Gly Gly Leu Gly Gly Leu Ser Leu Thr Thr Glu Pro Val 
        35                  40                  45              


Ser Ser Asn Pro Gly Tyr Ile Pro Ser Ser Glu Ala Asn Arg Pro Ser 
    50                  55                  60                  


His Leu Ser Ser Thr Gly Thr Pro Gly Ala Gly Val Pro Ser Ser Gly 
65                  70                  75                  80  


Arg Asp Gly Gly Thr Ser Arg Asp Thr Phe Gln Thr Val Pro Pro Asn 
                85                  90                  95      


Ser Thr Thr Met Ser Leu Ser Met Arg Glu Asp Ala Thr Ile Leu Pro 
            100                 105                 110         


Ser Pro Thr Ser Glu Thr Val Leu Thr Val Ala Ala Phe Gly Val Ile 
        115                 120                 125             


Ser Phe Ile Val Ile Leu Val Val Val Val Ile Ile Leu Val Gly Val 
    130                 135                 140                 


Val Ser Leu Arg Phe Lys Cys Arg Lys Ser Lys Glu Ser Glu Asp Pro 
145                 150                 155                 160 


Gln Lys Pro Gly Ser Ser Gly Leu Ser Glu Ser Cys Ser Thr Ala Asn 
                165                 170                 175     


Gly Glu Lys Asp Ser Ile Thr Leu Ile Ser Met Lys Asn Ile Asn Met 
            180                 185                 190         


Asn Asn Gly Lys Gln Ser Leu Ser Ala Glu Lys Val Leu 
        195                 200                 205 


<210>  980
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  980

Met Thr Thr Ser His Gln Pro Gln Asp Arg Tyr Lys Ala Val Trp Leu 
1               5                   10                  15      


Ile Phe Phe Met Leu Gly Leu Gly Thr Leu Leu Pro Trp Asn Phe Phe 
            20                  25                  30          


Met Thr Ala Thr Gln Tyr Phe Thr Asn Arg Leu Asp Met Ser Gln Asn 
        35                  40                  45              


Val Ser Leu Val Thr Ala Glu Leu Ser Lys Asp Ala Gln Ala Ser Ala 
    50                  55                  60                  


Ala Pro Ala Ala Pro Leu Pro Glu Arg Asn Ser Leu Ser Ala Ile Phe 
65                  70                  75                  80  


Asn Asn Val Met Thr Leu Cys Ala Met Leu Pro Leu Leu Leu Phe Thr 
                85                  90                  95      


Tyr Leu Asn Ser Phe Leu His Gln Arg Ile Pro Gln Ser Val Arg Ile 
            100                 105                 110         


Leu Gly Ser Leu Val Ala Ile Leu Leu Val Phe Leu Ile Thr Ala Ile 
        115                 120                 125             


Leu Val Lys Val Gln Leu Asp Ala Leu Pro Phe Phe Val Ile Thr Met 
    130                 135                 140                 


Ile Lys Ile Val Leu Ile Asn Ser Phe Gly Ala Ile Leu Gln Gly Ser 
145                 150                 155                 160 


Leu Phe Gly Leu Ala Gly Leu Leu Pro Ala Ser Tyr Thr Ala Pro Ile 
                165                 170                 175     


Met Ser Gly Gln Gly Leu Ala Gly Phe Phe Ala Ser Val Ala Met Ile 
            180                 185                 190         


Cys Ala Ile Ala Ser Gly Ser Glu Leu Ser Glu Ser Ala Phe Gly Tyr 
        195                 200                 205             


Phe Ile Thr Ala Cys Ala Val Ile Ile Leu Thr Ile Ile Cys Tyr Leu 
    210                 215                 220                 


Gly Leu Pro Arg Leu Glu Phe Tyr Arg Tyr Tyr Gln Gln Leu Lys Leu 
225                 230                 235                 240 


Glu Gly Pro Gly Glu Gln Glu Thr Lys Leu Asp Leu Ile Ser Lys Gly 
                245                 250                 255     


Glu Glu Pro Arg Ala Gly Lys Glu Glu Ser Gly Val Ser Val Ser Asn 
            260                 265                 270         


Ser Gln Pro Thr Asn Glu Ser His Ser Ile Lys Ala Ile Leu Lys Asn 
        275                 280                 285             


Ile Ser Val Leu Ala Phe Ser Val Cys Phe Ile Phe Thr Ile Thr Ile 
    290                 295                 300                 


Gly Met Phe Pro Ala Val Thr Val Glu Val Lys Ser Ser Ile Ala Gly 
305                 310                 315                 320 


Ser Ser Thr Trp Glu Arg Tyr Phe Ile Pro Val Ser Cys Phe Leu Thr 
                325                 330                 335     


Phe Asn Ile Phe Asp Trp Leu Gly Arg Ser Leu Thr Ala Val Phe Met 
            340                 345                 350         


Trp Pro Gly Lys Asp Ser Arg Trp Leu Pro Ser Leu Val Leu Ala Arg 
        355                 360                 365             


Leu Val Phe Val Pro Leu Leu Leu Leu Cys Asn Ile Lys Pro Arg Arg 
    370                 375                 380                 


Tyr Leu Thr Val Val Phe Glu His Asp Ala Trp Phe Ile Phe Phe Met 
385                 390                 395                 400 


Ala Ala Phe Ala Phe Ser Asn Gly Tyr Leu Ala Ser Leu Cys Met Cys 
                405                 410                 415     


Phe Gly Pro Lys Lys Val Lys Pro Ala Glu Ala Glu Thr Ala Gly Ala 
            420                 425                 430         


Ile Met Ala Phe Phe Leu Cys Leu Gly Leu Ala Leu Gly Ala Val Phe 
        435                 440                 445             


Ser Phe Leu Phe Arg Ala Ile Val 
    450                 455     


<210>  981
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  981

Met Thr Thr Ser His Gln Pro Gln Asp Arg Tyr Lys Ala Val Trp Leu 
1               5                   10                  15      


Ile Phe Phe Met Leu Gly Leu Gly Thr Leu Leu Pro Trp Asn Phe Phe 
            20                  25                  30          


Met Thr Ala Thr Gln Tyr Phe Thr Asn Arg Leu Asp Met Ser Gln Asn 
        35                  40                  45              


Val Ser Leu Val Thr Ala Glu Leu Ser Lys Asp Ala Gln Ala Ser Ala 
    50                  55                  60                  


Ala Pro Ala Ala Pro Leu Pro Glu Arg Asn Ser Leu Ser Ala Ile Phe 
65                  70                  75                  80  


Asn Asn Val Met Thr Leu Cys Ala Met Leu Pro Leu Leu Leu Phe Thr 
                85                  90                  95      


Tyr Leu Asn Ser Phe Leu His Gln Arg Ile Pro Gln Ser Val Arg Ile 
            100                 105                 110         


Leu Gly Ser Leu Val Ala Ile Leu Leu Val Phe Leu Ile Thr Ala Ile 
        115                 120                 125             


Leu Val Lys Val Gln Leu Asp Ala Leu Pro Phe Phe Val Ile Thr Met 
    130                 135                 140                 


Ile Lys Ile Val Leu Ile Asn Ser Phe Gly Ala Ile Leu Gln Gly Ser 
145                 150                 155                 160 


Leu Phe Gly Leu Ala Gly Leu Leu Pro Ala Ser Tyr Thr Ala Pro Ile 
                165                 170                 175     


Met Ser Gly Gln Gly Leu Ala Gly Phe Phe Ala Ser Val Ala Met Ile 
            180                 185                 190         


Cys Ala Ile Ala Ser Gly Ser Glu Leu Ser Glu Ser Ala Phe Gly Tyr 
        195                 200                 205             


Phe Ile Thr Ala Cys Ala Val Ile Ile Leu Thr Ile Ile Cys Tyr Leu 
    210                 215                 220                 


Gly Leu Pro Arg Leu Glu Phe Tyr Arg Tyr Tyr Gln Gln Leu Lys Leu 
225                 230                 235                 240 


Glu Gly Pro Gly Glu Gln Glu Thr Lys Leu Asp Leu Ile Ser Lys Gly 
                245                 250                 255     


Glu Glu Pro Arg Ala Gly Lys Glu Glu Ser Gly Val Ser Val Ser Asn 
            260                 265                 270         


Ser Gln Pro Thr Asn Glu Ser His Ser Ile Lys Ala Ile Leu Lys Asn 
        275                 280                 285             


Ile Ser Val Leu Ala Phe Ser Val Cys Phe Ile Phe Thr Ile Thr Ile 
    290                 295                 300                 


Gly Met Phe Pro Ala Val Thr Val Glu Val Lys Ser Ser Ile Ala Gly 
305                 310                 315                 320 


Ser Ser Thr Trp Glu Arg Tyr Phe Ile Pro Val Ser Cys Phe Leu Thr 
                325                 330                 335     


Phe Asn Ile Phe Asp Trp Leu Gly Arg Ser Leu Thr Ala Val Phe Met 
            340                 345                 350         


Trp Pro Gly Lys Asp Ser Arg Trp Leu Pro Ser Leu Val Leu Ala Arg 
        355                 360                 365             


Leu Val Phe Val Pro Leu Leu Leu Leu Cys Asn Ile Lys Pro Arg Arg 
    370                 375                 380                 


Tyr Leu Thr Val Val Phe Glu His Asp Ala Trp Phe Ile Phe Phe Met 
385                 390                 395                 400 


Ala Ala Phe Ala Phe Ser Asn Gly Tyr Leu Ala Ser Leu Cys Met Cys 
                405                 410                 415     


Phe Gly Pro Lys Lys Val Lys Pro Ala Glu Ala Glu Thr Ala Gly Ala 
            420                 425                 430         


Ile Met Ala Phe Phe Leu Cys Leu Gly Leu Ala Leu Gly Ala Val Phe 
        435                 440                 445             


Ser Phe Leu Phe Arg Ala Ile Val 
    450                 455     


<210>  982
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  982

Met Thr Thr Ser His Gln Pro Gln Asp Arg Tyr Lys Ala Val Trp Leu 
1               5                   10                  15      


Ile Phe Phe Met Leu Gly Leu Gly Thr Leu Leu Pro Trp Asn Phe Phe 
            20                  25                  30          


Met Thr Ala Thr Gln Tyr Phe Thr Asn Arg Leu Asp Met Ser Gln Asn 
        35                  40                  45              


Val Ser Leu Val Thr Ala Glu Leu Ser Lys Asp Ala Gln Ala Ser Ala 
    50                  55                  60                  


Ala Pro Ala Ala Pro Leu Pro Glu Arg Asn Ser Leu Ser Ala Ile Phe 
65                  70                  75                  80  


Asn Asn Val Met Thr Leu Cys Ala Met Leu Pro Leu Leu Leu Phe Thr 
                85                  90                  95      


Tyr Leu Asn Ser Phe Leu His Gln Arg Ile Pro Gln Ser Val Arg Ile 
            100                 105                 110         


Leu Gly Ser Leu Val Ala Ile Leu Leu Val Phe Leu Ile Thr Ala Ile 
        115                 120                 125             


Leu Val Lys Val Gln Leu Asp Ala Leu Pro Phe Phe Val Ile Thr Met 
    130                 135                 140                 


Ile Lys Ile Val Leu Ile Asn Ser Phe Gly Ala Ile Leu Gln Gly Ser 
145                 150                 155                 160 


Leu Phe Gly Leu Ala Gly Leu Leu Pro Ala Ser Tyr Thr Ala Pro Ile 
                165                 170                 175     


Met Ser Gly Gln Gly Leu Ala Gly Phe Phe Ala Ser Val Ala Met Ile 
            180                 185                 190         


Cys Ala Ile Ala Ser Gly Ser Glu Leu Ser Glu Ser Ala Phe Gly Tyr 
        195                 200                 205             


Phe Ile Thr Ala Cys Ala Val Ile Ile Leu Thr Ile Ile Cys Tyr Leu 
    210                 215                 220                 


Gly Leu Pro Arg Leu Glu Phe Tyr Arg Tyr Tyr Gln Gln Leu Lys Leu 
225                 230                 235                 240 


Glu Gly Pro Gly Glu Gln Glu Thr Lys Leu Asp Leu Ile Ser Lys Gly 
                245                 250                 255     


Glu Glu Pro Arg Ala Gly Lys Glu Glu Ser Gly Val Ser Val Ser Asn 
            260                 265                 270         


Ser Gln Pro Thr Asn Glu Ser His Ser Ile Lys Ala Ile Leu Lys Asn 
        275                 280                 285             


Ile Ser Val Leu Ala Phe Ser Val Cys Phe Ile Phe Thr Ile Thr Ile 
    290                 295                 300                 


Gly Met Phe Pro Ala Val Thr Val Glu Val Lys Ser Ser Ile Ala Gly 
305                 310                 315                 320 


Ser Ser Thr Trp Glu Arg Tyr Phe Ile Pro Val Ser Cys Phe Leu Thr 
                325                 330                 335     


Phe Asn Ile Phe Asp Trp Leu Gly Arg Ser Leu Thr Ala Val Phe Met 
            340                 345                 350         


Trp Pro Gly Lys Asp Ser Arg Trp Leu Pro Ser Leu Val Leu Ala Arg 
        355                 360                 365             


Leu Val Phe Val Pro Leu Leu Leu Leu Cys Asn Ile Lys Pro Arg Arg 
    370                 375                 380                 


Tyr Leu Thr Val Val Phe Glu His Asp Ala Trp Phe Ile Phe Phe Met 
385                 390                 395                 400 


Ala Ala Phe Ala Phe Ser Asn Gly Tyr Leu Ala Ser Leu Cys Met Cys 
                405                 410                 415     


Phe Gly Pro Lys Lys Val Lys Pro Ala Glu Ala Glu Thr Ala Gly Ala 
            420                 425                 430         


Ile Met Ala Phe Phe Leu Cys Leu Gly Leu Ala Leu Gly Ala Val Phe 
        435                 440                 445             


Ser Phe Leu Phe Arg Ala Ile Val 
    450                 455     


<210>  983
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  983

Met Thr Thr Ser His Gln Pro Gln Asp Arg Tyr Lys Ala Val Trp Leu 
1               5                   10                  15      


Ile Phe Phe Met Leu Gly Leu Gly Thr Leu Leu Pro Trp Asn Phe Phe 
            20                  25                  30          


Met Thr Ala Thr Gln Tyr Phe Thr Asn Arg Leu Asp Met Ser Gln Asn 
        35                  40                  45              


Val Ser Leu Val Thr Ala Glu Leu Ser Lys Asp Ala Gln Ala Ser Ala 
    50                  55                  60                  


Ala Pro Ala Ala Pro Leu Pro Glu Arg Asn Ser Leu Ser Ala Ile Phe 
65                  70                  75                  80  


Asn Asn Val Met Thr Leu Cys Ala Met Leu Pro Leu Leu Leu Phe Thr 
                85                  90                  95      


Tyr Leu Asn Ser Phe Leu His Gln Arg Ile Pro Gln Ser Val Arg Ile 
            100                 105                 110         


Leu Gly Ser Leu Val Ala Ile Leu Leu Val Phe Leu Ile Thr Ala Ile 
        115                 120                 125             


Leu Val Lys Val Gln Leu Asp Ala Leu Pro Phe Phe Val Ile Thr Met 
    130                 135                 140                 


Ile Lys Ile Val Leu Ile Asn Ser Phe Gly Ala Ile Leu Gln Gly Ser 
145                 150                 155                 160 


Leu Phe Gly Leu Ala Gly Leu Leu Pro Ala Ser Tyr Thr Ala Pro Ile 
                165                 170                 175     


Met Ser Gly Gln Gly Leu Ala Gly Phe Phe Ala Ser Val Ala Met Ile 
            180                 185                 190         


Cys Ala Ile Ala Ser Gly Ser Glu Leu Ser Glu Ser Ala Phe Gly Tyr 
        195                 200                 205             


Phe Ile Thr Ala Cys Ala Val Ile Ile Leu Thr Ile Ile Cys Tyr Leu 
    210                 215                 220                 


Gly Leu Pro Arg Leu Glu Phe Tyr Arg Tyr Tyr Gln Gln Leu Lys Leu 
225                 230                 235                 240 


Glu Gly Pro Gly Glu Gln Glu Thr Lys Leu Asp Leu Ile Ser Lys Gly 
                245                 250                 255     


Glu Glu Pro Arg Ala Gly Lys Glu Glu Ser Gly Val Ser Val Ser Asn 
            260                 265                 270         


Ser Gln Pro Thr Asn Glu Ser His Ser Ile Lys Ala Ile Leu Lys Asn 
        275                 280                 285             


Ile Ser Val Leu Ala Phe Ser Val Cys Phe Ile Phe Thr Ile Thr Ile 
    290                 295                 300                 


Gly Met Phe Pro Ala Val Thr Val Glu Val Lys Ser Ser Ile Ala Gly 
305                 310                 315                 320 


Ser Ser Thr Trp Glu Arg Tyr Phe Ile Pro Val Ser Cys Phe Leu Thr 
                325                 330                 335     


Phe Asn Ile Phe Asp Trp Leu Gly Arg Ser Leu Thr Ala Val Phe Met 
            340                 345                 350         


Trp Pro Gly Lys Asp Ser Arg Trp Leu Pro Ser Leu Val Leu Ala Arg 
        355                 360                 365             


Leu Val Phe Val Pro Leu Leu Leu Leu Cys Asn Ile Lys Pro Arg Arg 
    370                 375                 380                 


Tyr Leu Thr Val Val Phe Glu His Asp Ala Trp Phe Ile Phe Phe Met 
385                 390                 395                 400 


Ala Ala Phe Ala Phe Ser Asn Gly Tyr Leu Ala Ser Leu Cys Met Cys 
                405                 410                 415     


Phe Gly Pro Lys Lys Val Lys Pro Ala Glu Ala Glu Thr Ala Gly Ala 
            420                 425                 430         


Ile Met Ala Phe Phe Leu Cys Leu Gly Leu Ala Leu Gly Ala Val Phe 
        435                 440                 445             


Ser Phe Leu Phe Arg Ala Ile Val 
    450                 455     


<210>  984
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  984

Met Ser Ala Ala Arg Pro Gln Phe Ser Ile Asp Asp Ala Phe Glu Leu 
1               5                   10                  15      


Ser Leu Glu Asp Gly Gly Pro Gly Pro Glu Ser Ser Gly Val Ala Arg 
            20                  25                  30          


Phe Gly Pro Leu His Phe Glu Arg Arg Ala Arg Phe Glu Val Ala Asp 
        35                  40                  45              


Glu Asp Lys Gln Ser Arg Leu Arg Tyr Gln Asn Leu Glu Asn Asp Glu 
    50                  55                  60                  


Asp Gly Ala Gln Ala Ser Pro Glu Pro Asp Gly Gly Val Gly Thr Arg 
65                  70                  75                  80  


Asp Ser Ser Arg Thr Ser Ile Arg Ser Ser Gln Trp Ser Phe Ser Thr 
                85                  90                  95      


Ile Ser Ser Ser Thr Gln Arg Ser Tyr Asn Thr Cys Cys Ser Trp Thr 
            100                 105                 110         


Gln His Pro Leu Ile Gln Lys Asn Arg Arg Val Val Leu Ala Ser Phe 
        115                 120                 125             


Leu Leu Leu Leu Leu Gly Leu Gly Val Ser Ser Ala Ile Phe Phe Val 
    130                 135                 140                 


Pro Gly Phe Leu Leu Leu Val Pro Gly Val Tyr His Val Ile Phe Ile 
145                 150                 155                 160 


Tyr Cys Ala Val Lys Gly His Arg Gly Phe Gln Phe Phe Tyr Leu Pro 
                165                 170                 175     


Tyr Phe Glu Lys 
            180 


<210>  985
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  985

Met Ser Ala Ala Arg Pro Gln Phe Ser Ile Asp Asp Ala Phe Glu Leu 
1               5                   10                  15      


Ser Leu Glu Asp Gly Gly Pro Gly Pro Glu Ser Ser Gly Val Ala Arg 
            20                  25                  30          


Phe Gly Pro Leu His Phe Glu Arg Arg Ala Arg Phe Glu Val Ala Asp 
        35                  40                  45              


Glu Asp Lys Gln Ser Arg Leu Arg Tyr Gln Asn Leu Glu Asn Asp Glu 
    50                  55                  60                  


Asp Gly Ala Gln Ala Ser Pro Glu Pro Asp Gly Gly Val Gly Thr Ser 
65                  70                  75                  80  


Ser Gln Trp Ser Phe Ser Thr Ile Ser Ser Ser Thr Gln Arg Ser Tyr 
                85                  90                  95      


Asn Thr Cys Cys Ser Trp Thr Gln His Pro Leu Ile Gln Lys Asn Arg 
            100                 105                 110         


Arg Val Val Leu Ala Ser Phe Leu Leu Leu Leu Leu Gly Leu Val Leu 
        115                 120                 125             


Ile Leu Val Gly Val Gly Leu Glu Ala Thr Pro Ser Pro Gly Val Ser 
    130                 135                 140                 


Ser Ala Ile Phe Phe Val Pro Gly Phe Leu Leu Leu Val Pro Gly Val 
145                 150                 155                 160 


Tyr His Val Ile Phe Ile Tyr Cys Ala Val Lys Gly His Arg Gly Phe 
                165                 170                 175     


Gln Phe Phe Tyr Leu Pro Tyr Phe Glu Lys 
            180                 185     


<210>  986
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  986

Met Lys Gln Ala Leu Val Asp Asp Thr Glu Asp Val Ser Leu Asp Phe 
1               5                   10                  15      


Gly Asn Glu Glu Glu Leu Ala Phe Arg Lys Ala Lys Ile Arg His Pro 
            20                  25                  30          


Leu Ala Thr Phe Phe His Leu Phe Phe Arg Val Ser Ala Ile Val Thr 
        35                  40                  45              


Tyr Val Ser Cys Asp Trp Phe Ser Lys Ser Phe Val Gly Cys Phe Val 
    50                  55                  60                  


Met Val Leu Leu Leu Leu Ser Leu Asp Phe Trp Ser Val Lys Asn Val 
65                  70                  75                  80  


Thr Gly Arg Leu Leu Val Gly Leu Arg Trp Trp Asn Gln Ile Asp Glu 
                85                  90                  95      


Asp Gly Lys Ser His Trp Ile Phe Glu Ala Arg Lys Val Ser Pro Asn 
            100                 105                 110         


Ser Ile Ala Ala Thr Glu Ala Glu Ala Arg Ile Phe Trp Leu Gly Leu 
        115                 120                 125             


Ile Ile Cys Pro Met Ile Trp Ile Val Phe Phe Phe Ser Thr Leu Phe 
    130                 135                 140                 


Ser Leu Lys Leu Lys Trp Leu Ala Leu Val Val Ala Gly Ile Ser Leu 
145                 150                 155                 160 


Gln Ala Ala Asn Leu Tyr Gly Tyr Ile Leu Cys Lys Met Gly Gly Asn 
                165                 170                 175     


Ser Asp Ile Gly Lys Val Thr Ala Ser Phe Leu Ser Gln Thr Val Phe 
            180                 185                 190         


Gln Thr Ala Cys Pro Gly Asp Phe Gln Lys Pro Gly Leu Glu Gly Leu 
        195                 200                 205             


Glu Ile His Gln His 
    210             


<210>  987
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  987

Met Ala Ala Pro Ala Glu Pro Cys Ala Gly Gln Gly Val Trp Asn Gln 
1               5                   10                  15      


Thr Glu Pro Glu Pro Ala Ala Thr Ser Leu Leu Ser Leu Cys Phe Leu 
            20                  25                  30          


Arg Thr Ala Gly Val Trp Val Pro Pro Met Tyr Leu Trp Val Leu Gly 
        35                  40                  45              


Pro Ile Tyr Leu Leu Phe Ile His His His Gly Arg Gly Tyr Leu Arg 
    50                  55                  60                  


Met Ser Pro Leu Phe Lys Ala Lys Met Val Ala Ala Ile Pro Gly Ser 
65                  70                  75                  80  


Leu Glu Pro Gly Asn Val Arg Gly Arg Gln Gly Thr Gly Trp Asn Leu 
                85                  90                  95      


Val Lys Ser 
            


<210>  988
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  988

Met Ser Gln Leu Ser Leu Ser Trp Leu Gly Leu Trp Pro Val Ala Ala 
1               5                   10                  15      


Ser Pro Trp Leu Leu Leu Leu Leu Val Gly Ala Ser Trp Leu Leu Ala 
            20                  25                  30          


His Val Leu Ala Trp Thr Tyr Ala Phe Tyr Asp Asn Cys Arg Arg Leu 
        35                  40                  45              


Arg Cys Phe Pro Gln Pro Pro Arg Arg Asn Trp Phe Trp Gly His Gln 
    50                  55                  60                  


Gly Met Val Asn Pro Thr Glu Glu Gly Met Arg Val Leu Thr Gln Leu 
65                  70                  75                  80  


Val Ala Thr Tyr Pro Gln Gly Phe Lys Val Trp Met Gly Pro Ile Ser 
                85                  90                  95      


Pro Leu Leu Ser Leu Cys His Pro Asp Ile Ile Arg Ser Val Ile Asn 
            100                 105                 110         


Ala Ser Ala Ala Ile Ala Pro Lys Asp Lys Phe Phe Tyr Ser Phe Leu 
        115                 120                 125             


Glu Pro Trp Leu Gly Asp Gly Leu Leu Leu Ser Ala Gly Asp Lys Trp 
    130                 135                 140                 


Ser Arg His Arg Arg Met Leu Thr Pro Ala Phe His Phe Asn Ile Leu 
145                 150                 155                 160 


Lys Pro Tyr Met Lys Ile Phe Asn Glu Ser Val Asn Ile Met His Ala 
                165                 170                 175     


Lys Trp Gln Leu Leu Ala Ser Glu Gly Ser Ala Cys Leu Asp Met Phe 
            180                 185                 190         


Glu His Ile Ser Leu Met Thr Leu Asp Ser Leu Gln Lys Cys Val Phe 
        195                 200                 205             


Ser Phe Asp Ser His Cys Gln Glu Lys Pro Ser Glu Tyr Ile Ala Ala 
    210                 215                 220                 


Ile Leu Glu Leu Ser Ala Leu Val Ser Lys Arg His His Glu Ile Leu 
225                 230                 235                 240 


Leu His Ile Asp Phe Leu Tyr Tyr Leu Thr Pro Asp Gly Gln Arg Phe 
                245                 250                 255     


Arg Arg Ala Cys Arg Leu Val His Asp Phe Thr Asp Ala Val Ile Gln 
            260                 265                 270         


Glu Arg Arg Arg Thr Leu Pro Ser Gln Gly Val Asp Asp Phe Leu Gln 
        275                 280                 285             


Ala Lys Ala Lys Ser Lys Thr Leu Asp Phe Ile Asp Val Leu Leu Leu 
    290                 295                 300                 


Ser Lys Asp Glu Asp Gly Lys Lys Leu Ser Asp Glu Asp Ile Arg Ala 
305                 310                 315                 320 


Glu Ala Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ser Gly 
                325                 330                 335     


Leu Ser Trp Val Leu Tyr His Leu Ala Lys His Pro Glu Tyr Gln Glu 
            340                 345                 350         


Arg Cys Arg Gln Glu Val Gln Glu Leu Leu Lys Asp Arg Glu Pro Lys 
        355                 360                 365             


Glu Ile Glu Trp Asp Asp Leu Ala His Leu Pro Phe Leu Thr Met Cys 
    370                 375                 380                 


Met Lys Glu Ser Leu Arg Leu His Pro Pro Val Pro Val Ile Ser Arg 
385                 390                 395                 400 


His Val Thr Gln Asp Ile Val Leu Pro Asp Gly Arg Val Ile Pro Lys 
                405                 410                 415     


Gly Ile Ile Cys Leu Ile Ser Val Phe Gly Thr His His Asn Pro Ala 
            420                 425                 430         


Val Trp Pro Asp Pro Glu Val Tyr Asp Pro Phe Arg Phe Asp Pro Glu 
        435                 440                 445             


Asn Ile Lys Glu Arg Ser Pro Leu Ala Phe Ile Pro Phe Ser Ala Gly 
    450                 455                 460                 


Pro Arg Asn Cys Ile Gly Gln Thr Phe Ala Met Ala Glu Met Lys Val 
465                 470                 475                 480 


Val Leu Ala Leu Thr Leu Leu Arg Phe Arg Val Leu Pro Asp His Thr 
                485                 490                 495     


Glu Pro Arg Arg Lys Pro Glu Leu Val Leu Arg Ala Glu Gly Gly Leu 
            500                 505                 510         


Trp Leu Arg Val Glu Pro Leu Ser 
        515                 520 


<210>  989
<211>  679
<212>  PRT
<213>  Homo sapiens

<400>  989

Met Gln Val Arg Glu Leu Pro Arg Gly Glu Trp Gln Thr Tyr Ser Ser 
1               5                   10                  15      


Ser Ile Ser His Glu Ala Thr Ala Cys Val Val Asp Arg Leu Arg Pro 
            20                  25                  30          


Phe Thr Ser Tyr Lys Leu Arg Leu Lys Ala Thr Asn Asp Ile Gly Asp 
        35                  40                  45              


Ser Asp Phe Ser Ser Glu Thr Glu Ala Val Thr Thr Leu Gln Asp Val 
    50                  55                  60                  


Pro Gly Glu Pro Pro Gly Ser Val Ser Ala Thr Pro His Thr Thr Ser 
65                  70                  75                  80  


Ser Val Leu Ile Gln Trp Gln Pro Pro Arg Asp Glu Ser Leu Asn Gly 
                85                  90                  95      


Leu Leu Gln Gly Tyr Arg Ile Tyr Tyr Arg Glu Leu Glu Tyr Glu Ala 
            100                 105                 110         


Gly Ser Gly Thr Glu Ala Lys Thr Leu Lys Asn Pro Ile Ala Leu His 
        115                 120                 125             


Ala Glu Leu Thr Ala Gln Ser Ser Phe Lys Thr Val Asn Ser Ser Ser 
    130                 135                 140                 


Thr Ser Thr Met Cys Glu Leu Thr His Leu Lys Lys Tyr Arg Arg Tyr 
145                 150                 155                 160 


Glu Val Ile Met Thr Ala Tyr Asn Ile Ile Gly Glu Ser Pro Ala Ser 
                165                 170                 175     


Ala Pro Val Glu Val Phe Val Gly Glu Ala Ala Pro Ala Met Ala Pro 
            180                 185                 190         


Gln Asn Val Gln Val Thr Pro Leu Thr Ala Ser Gln Leu Glu Val Thr 
        195                 200                 205             


Trp Asp Pro Pro Pro Pro Glu Ser Gln Asn Gly Asn Ile Gln Gly Tyr 
    210                 215                 220                 


Lys Ile Tyr Tyr Trp Glu Ala Asp Ser Gln Asn Glu Thr Glu Lys Met 
225                 230                 235                 240 


Lys Val Leu Phe Leu Pro Glu Pro Val Val Arg Leu Lys Asn Leu Thr 
                245                 250                 255     


Ser His Thr Lys Tyr Leu Val Ser Ile Ser Ala Phe Asn Ala Ala Gly 
            260                 265                 270         


Asp Gly Pro Lys Ser Asp Pro Gln Gln Gly Arg Thr His Gln Ala Ala 
        275                 280                 285             


Pro Gly Ala Pro Ser Phe Leu Ala Phe Ser Glu Ile Thr Ser Thr Thr 
    290                 295                 300                 


Leu Asn Val Ser Trp Gly Glu Pro Ala Ala Ala Asn Gly Ile Leu Gln 
305                 310                 315                 320 


Gly Tyr Arg Val Val Tyr Glu Pro Leu Ala Pro Val Gln Gly Val Ser 
                325                 330                 335     


Lys Val Val Thr Val Glu Val Arg Gly Asn Trp Gln Arg Trp Leu Lys 
            340                 345                 350         


Val Arg Asp Leu Thr Lys Gly Val Thr Tyr Phe Phe Arg Val Gln Ala 
        355                 360                 365             


Arg Thr Ile Thr Tyr Gly Pro Glu Leu Gln Ala Asn Ile Thr Ala Gly 
    370                 375                 380                 


Pro Ala Glu Gly Ser Pro Gly Ser Pro Arg Asp Val Leu Val Thr Lys 
385                 390                 395                 400 


Ser Ala Ser Glu Leu Thr Leu Gln Trp Thr Glu Gly His Ser Gly Asp 
                405                 410                 415     


Thr Pro Thr Thr Gly Tyr Val Ile Glu Ala Arg Pro Ser Asp Glu Gly 
            420                 425                 430         


Leu Trp Asp Met Phe Val Lys Asp Ile Pro Arg Ser Ala Thr Ser Tyr 
        435                 440                 445             


Thr Leu Ser Leu Asp Lys Leu Arg Gln Gly Val Thr Tyr Glu Phe Arg 
    450                 455                 460                 


Val Val Ala Val Asn Glu Ala Gly Tyr Gly Glu Pro Ser Asn Pro Ser 
465                 470                 475                 480 


Thr Ala Val Ser Ala Gln Val Glu Ala Pro Phe Tyr Glu Glu Trp Trp 
                485                 490                 495     


Phe Leu Leu Val Met Ala Leu Ser Ser Leu Ile Val Ile Leu Leu Val 
            500                 505                 510         


Val Phe Ala Leu Val Leu His Gly Gln Asn Lys Lys Tyr Lys Asn Cys 
        515                 520                 525             


Ser Thr Gly Lys Gly Ile Ser Thr Met Glu Glu Ser Val Thr Leu Asp 
    530                 535                 540                 


Asn Gly Gly Phe Ala Ala Leu Glu Leu Ser Ser Arg His Leu Asn Val 
545                 550                 555                 560 


Lys Ser Thr Phe Ser Lys Lys Asn Gly Thr Arg Ser Pro Pro Arg Pro 
                565                 570                 575     


Ser Pro Gly Gly Leu His Tyr Ser Asp Glu Asp Ile Cys Asn Lys Tyr 
            580                 585                 590         


Asn Gly Ala Val Leu Thr Glu Ser Val Ser Leu Lys Glu Lys Ser Ala 
        595                 600                 605             


Asp Ala Ser Glu Ser Glu Ala Thr Asp Ser Asp Tyr Glu Asp Ala Leu 
    610                 615                 620                 


Pro Lys His Ser Phe Val Asn His Tyr Met Ser Asp Pro Thr Tyr Tyr 
625                 630                 635                 640 


Asn Ser Trp Lys Arg Arg Ala Gln Gly Arg Ala Pro Ala Pro His Ser 
                645                 650                 655     


Val Ala Ile Leu Leu Thr Ser Asn Pro Ser Ala Tyr Leu Ser Val Ala 
            660                 665                 670         


Pro Arg Gly Ser Ala Ser Trp 
        675                 


<210>  990
<211>  741
<212>  PRT
<213>  Homo sapiens

<400>  990

Met Ala Val Leu Asp Thr Asp Leu Asp His Ile Leu Pro Ser Ser Val 
1               5                   10                  15      


Leu Pro Pro Phe Trp Ala Lys Leu Val Val Gly Ser Val Ala Ile Val 
            20                  25                  30          


Cys Phe Ala Arg Ser Tyr Asp Gly Asp Phe Val Phe Asp Asp Ser Glu 
        35                  40                  45              


Ala Ile Val Asn Asn Lys Asp Leu Gln Ala Glu Thr Pro Leu Gly Asp 
    50                  55                  60                  


Leu Trp His His Asp Phe Trp Gly Ser Arg Leu Ser Ser Asn Thr Ser 
65                  70                  75                  80  


His Lys Ser Tyr Arg Pro Leu Thr Val Leu Thr Phe Arg Ile Asn Tyr 
                85                  90                  95      


Tyr Leu Ser Gly Gly Phe His Pro Val Gly Phe His Val Val Asn Ile 
            100                 105                 110         


Leu Leu His Ser Gly Ile Ser Val Leu Met Val Asp Val Phe Ser Val 
        115                 120                 125             


Leu Phe Gly Gly Leu Gln Tyr Thr Ser Lys Gly Arg Arg Leu His Leu 
    130                 135                 140                 


Ala Pro Arg Ala Ser Leu Leu Ala Ala Leu Leu Phe Ala Val His Pro 
145                 150                 155                 160 


Val His Thr Glu Cys Val Ala Gly Val Val Gly Arg Ala Asp Leu Leu 
                165                 170                 175     


Cys Ala Leu Phe Phe Leu Leu Ser Phe Leu Gly Tyr Cys Lys Ala Phe 
            180                 185                 190         


Arg Glu Ser Asn Lys Glu Gly Ala His Ser Ser Thr Phe Trp Val Leu 
        195                 200                 205             


Leu Ser Ile Phe Leu Gly Ala Val Ala Met Leu Cys Lys Glu Gln Gly 
    210                 215                 220                 


Ile Thr Val Leu Gly Leu Asn Ala Val Phe Asp Ile Leu Val Ile Gly 
225                 230                 235                 240 


Lys Phe Asn Val Leu Glu Ile Val Gln Lys Val Leu His Lys Asp Lys 
                245                 250                 255     


Ser Leu Glu Asn Leu Gly Met Leu Arg Asn Gly Gly Leu Leu Phe Arg 
            260                 265                 270         


Met Thr Leu Leu Thr Ser Gly Gly Ala Gly Met Leu Tyr Val Arg Trp 
        275                 280                 285             


Arg Ile Met Gly Thr Gly Pro Pro Ala Phe Thr Glu Val Asp Asn Pro 
    290                 295                 300                 


Ala Ser Phe Ala Asp Ser Met Leu Val Arg Ala Val Asn Tyr Asn Tyr 
305                 310                 315                 320 


Tyr Tyr Ser Leu Asn Ala Trp Leu Leu Leu Cys Pro Trp Trp Leu Cys 
                325                 330                 335     


Phe Asp Trp Ser Met Gly Cys Ile Pro Leu Ile Lys Ser Ile Ser Asp 
            340                 345                 350         


Trp Arg Val Ile Ala Leu Ala Ala Leu Trp Phe Cys Leu Ile Gly Leu 
        355                 360                 365             


Ile Cys Gln Ala Leu Cys Ser Glu Asp Gly His Lys Arg Arg Ile Leu 
    370                 375                 380                 


Thr Leu Gly Leu Gly Phe Leu Val Ile Pro Phe Leu Pro Ala Ser Asn 
385                 390                 395                 400 


Leu Phe Phe Arg Val Gly Phe Val Val Ala Glu Arg Val Leu Tyr Leu 
                405                 410                 415     


Pro Ser Val Gly Tyr Cys Val Leu Leu Thr Phe Gly Phe Gly Ala Leu 
            420                 425                 430         


Ser Lys His Thr Lys Lys Lys Lys Leu Ile Ala Ala Val Val Leu Gly 
        435                 440                 445             


Ile Leu Phe Ile Asn Thr Leu Arg Cys Val Leu Arg Ser Gly Glu Trp 
    450                 455                 460                 


Arg Ser Glu Glu Gln Leu Phe Arg Ser Ala Leu Ser Val Cys Pro Leu 
465                 470                 475                 480 


Asn Ala Lys Val His Tyr Asn Ile Gly Lys Asn Leu Ala Asp Lys Gly 
                485                 490                 495     


Asn Gln Thr Ala Ala Ile Arg Tyr Tyr Arg Glu Ala Val Arg Leu Asn 
            500                 505                 510         


Pro Lys Tyr Val His Ala Met Asn Asn Leu Gly Asn Ile Leu Lys Glu 
        515                 520                 525             


Arg Asn Glu Leu Gln Glu Ala Glu Glu Leu Leu Ser Leu Ala Val Gln 
    530                 535                 540                 


Ile Gln Pro Asp Phe Ala Ala Ala Trp Met Asn Leu Gly Ile Val Gln 
545                 550                 555                 560 


Asn Ser Leu Lys Arg Phe Glu Ala Ala Glu Gln Ser Tyr Arg Thr Ala 
                565                 570                 575     


Ile Lys His Arg Arg Lys Tyr Pro Asp Cys Tyr Tyr Asn Leu Gly Arg 
            580                 585                 590         


Leu Tyr Ala Asp Leu Asn Arg His Val Asp Ala Leu Asn Ala Trp Arg 
        595                 600                 605             


Asn Ala Thr Val Leu Lys Pro Glu His Ser Leu Ala Trp Asn Asn Met 
    610                 615                 620                 


Ile Ile Leu Leu Asp Asn Thr Gly Asn Leu Ala Gln Ala Glu Ala Val 
625                 630                 635                 640 


Gly Arg Glu Ala Leu Glu Leu Ile Pro Asn Asp His Ser Leu Met Phe 
                645                 650                 655     


Ser Leu Ala Asn Val Leu Gly Lys Ser Gln Lys Tyr Lys Glu Ser Glu 
            660                 665                 670         


Ala Leu Phe Leu Lys Ala Ile Lys Ala Asn Pro Asn Ala Ala Ser Tyr 
        675                 680                 685             


His Gly Asn Leu Ala Val Leu Tyr His Arg Trp Gly His Leu Asp Leu 
    690                 695                 700                 


Ala Lys Lys His Tyr Glu Ile Ser Leu Gln Leu Asp Pro Thr Ala Ser 
705                 710                 715                 720 


Gly Thr Lys Glu Asn Tyr Gly Leu Leu Arg Arg Lys Leu Glu Leu Met 
                725                 730                 735     


Gln Lys Lys Ala Val 
            740     


<210>  991
<211>  1198
<212>  PRT
<213>  Homo sapiens

<400>  991

Met Ala Glu His Pro Pro Leu Leu Asp Thr Thr Gln Ile Leu Ser Ser 
1               5                   10                  15      


Asp Ile Ser Leu Leu Ser Ala Pro Ile Val Ser Ala Asp Gly Thr Gln 
            20                  25                  30          


Gln Val Ile Leu Val Gln Val Asn Pro Gly Glu Ala Phe Thr Ile Arg 
        35                  40                  45              


Arg Glu Asp Gly Gln Phe Gln Cys Ile Thr Gly Pro Ala Gln Val Pro 
    50                  55                  60                  


Met Met Ser Pro Asn Gly Ser Val Pro Pro Ile Tyr Val Pro Pro Gly 
65                  70                  75                  80  


Tyr Ala Pro Gln Val Ile Glu Asp Asn Gly Val Arg Arg Val Val Val 
                85                  90                  95      


Val Pro Gln Ala Pro Glu Phe His Pro Gly Ser His Thr Val Leu His 
            100                 105                 110         


Arg Ser Pro His Pro Pro Leu Pro Gly Phe Ile Pro Val Pro Thr Met 
        115                 120                 125             


Met Pro Pro Pro Pro Arg His Met Tyr Ser Pro Val Thr Gly Ala Gly 
    130                 135                 140                 


Asp Met Thr Thr Gln Tyr Met Pro Gln Tyr Gln Ser Ser Gln Val Tyr 
145                 150                 155                 160 


Gly Asp Val Asp Ala His Ser Thr His Gly Arg Ser Asn Phe Arg Asp 
                165                 170                 175     


Glu Arg Ser Ser Lys Thr Tyr Glu Arg Leu Gln Lys Lys Leu Lys Asp 
            180                 185                 190         


Arg Gln Gly Thr Gln Lys Asp Lys Met Ser Ser Pro Pro Ser Ser Pro 
        195                 200                 205             


Gln Lys Cys Pro Ser Pro Ile Asn Glu His Asn Gly Leu Ile Lys Gly 
    210                 215                 220                 


Gln Ile Ala Gly Gly Ile Asn Thr Gly Ser Ala Lys Ile Lys Ser Gly 
225                 230                 235                 240 


Lys Gly Lys Gly Gly Thr Gln Val Asp Thr Glu Ile Glu Glu Lys Asp 
                245                 250                 255     


Glu Glu Thr Lys Ala Phe Glu Ala Leu Leu Ser Asn Ile Val Lys Pro 
            260                 265                 270         


Val Ala Ser Asp Ile Gln Ala Arg Thr Val Val Leu Thr Trp Ser Pro 
        275                 280                 285             


Pro Ser Ser Leu Ile Asn Gly Glu Thr Asp Glu Ser Ser Val Pro Glu 
    290                 295                 300                 


Leu Tyr Gly Tyr Glu Val Leu Ile Ser Ser Thr Gly Lys Asp Gly Lys 
305                 310                 315                 320 


Tyr Lys Ser Val Tyr Val Gly Glu Glu Thr Asn Ile Thr Leu Asn Asp 
                325                 330                 335     


Leu Lys Pro Ala Met Asp Tyr His Ala Lys Val Gln Ala Glu Tyr Asn 
            340                 345                 350         


Ser Ile Lys Gly Thr Pro Ser Glu Ala Glu Ile Phe Thr Thr Leu Ser 
        355                 360                 365             


Cys Glu Pro Asp Ile Pro Asn Pro Pro Arg Ile Ala Asn Arg Thr Lys 
    370                 375                 380                 


Asn Ser Leu Thr Leu Gln Trp Lys Ala Pro Ser Asp Asn Gly Ser Lys 
385                 390                 395                 400 


Ile Gln Asn Phe Val Leu Glu Trp Asp Glu Gly Lys Gly Asn Gly Glu 
                405                 410                 415     


Phe Cys Gln Cys Tyr Met Gly Ser Gln Lys Gln Phe Lys Ile Thr Lys 
            420                 425                 430         


Leu Ser Pro Ala Met Gly Cys Lys Phe Arg Leu Ser Ala Arg Asn Asp 
        435                 440                 445             


Tyr Gly Thr Ser Gly Phe Ser Glu Glu Val Leu Tyr Tyr Thr Ser Gly 
    450                 455                 460                 


Cys Ala Pro Ser Met Pro Ala Ser Pro Val Leu Thr Lys Ala Gly Ile 
465                 470                 475                 480 


Thr Trp Leu Ser Leu Gln Trp Ser Lys Pro Ser Gly Thr Pro Ser Asp 
                485                 490                 495     


Glu Gly Ile Ser Tyr Ile Leu Glu Met Glu Glu Glu Thr Ser Gly Tyr 
            500                 505                 510         


Gly Phe Lys Pro Lys Tyr Asp Gly Glu Asp Leu Ala Tyr Thr Val Lys 
        515                 520                 525             


Asn Leu Arg Arg Ser Thr Lys Tyr Lys Phe Lys Val Ile Ala Tyr Asn 
    530                 535                 540                 


Ser Glu Gly Lys Ser Asn Pro Ser Glu Val Val Glu Phe Thr Thr Cys 
545                 550                 555                 560 


Pro Asp Lys Pro Gly Ile Pro Val Lys Pro Ser Val Lys Gly Lys Ile 
                565                 570                 575     


His Ser His Ser Phe Lys Ile Thr Trp Asp Pro Pro Lys Asp Asn Gly 
            580                 585                 590         


Gly Ala Thr Ile Asn Lys Tyr Val Val Glu Met Ala Glu Gly Ser Asn 
        595                 600                 605             


Gly Asn Lys Trp Glu Met Ile Tyr Ser Gly Ala Thr Arg Glu His Leu 
    610                 615                 620                 


Cys Asp Arg Leu Asn Pro Gly Cys Phe Tyr Arg Leu Arg Val Tyr Cys 
625                 630                 635                 640 


Ile Ser Asp Gly Gly Gln Ser Ala Val Ser Glu Ser Leu Leu Val Gln 
                645                 650                 655     


Thr Pro Ala Val Pro Pro Gly Pro Cys Leu Pro Pro Arg Leu Gln Gly 
            660                 665                 670         


Arg Pro Lys Ala Lys Glu Ile Gln Leu Arg Trp Gly Pro Pro Leu Val 
        675                 680                 685             


Asp Gly Gly Ser Pro Ile Ser Cys Tyr Ser Val Glu Met Ser Pro Ile 
    690                 695                 700                 


Glu Lys Asp Glu Pro Arg Glu Val Tyr Gln Gly Ser Glu Val Glu Cys 
705                 710                 715                 720 


Thr Val Ser Ser Leu Leu Pro Gly Lys Thr Tyr Ser Phe Arg Leu Arg 
                725                 730                 735     


Ala Ala Asn Lys Met Gly Phe Gly Pro Phe Ser Glu Lys Cys Asp Ile 
            740                 745                 750         


Thr Thr Ala Pro Gly Pro Pro Asp Gln Cys Lys Pro Pro Gln Val Thr 
        755                 760                 765             


Cys Arg Ser Ala Thr Cys Ala Gln Val Asn Trp Glu Val Pro Leu Ser 
    770                 775                 780                 


Asn Gly Thr Asp Val Thr Glu Tyr Arg Leu Glu Trp Gly Gly Val Glu 
785                 790                 795                 800 


Gly Ser Met Gln Ile Cys Tyr Cys Gly Pro Gly Leu Ser Tyr Glu Ile 
                805                 810                 815     


Lys Gly Leu Ser Pro Ala Thr Thr Tyr Tyr Cys Arg Val Gln Ala Leu 
            820                 825                 830         


Ser Val Val Gly Ala Gly Pro Phe Ser Glu Val Val Ala Cys Val Thr 
        835                 840                 845             


Pro Pro Ser Val Pro Gly Ile Val Thr Cys Leu Gln Glu Ile Ser Asp 
    850                 855                 860                 


Asp Glu Ile Glu Asn Pro His Tyr Ser Pro Ser Thr Cys Leu Ala Ile 
865                 870                 875                 880 


Ser Trp Glu Lys Pro Cys Asp His Gly Ser Glu Ile Leu Ala Tyr Ser 
                885                 890                 895     


Ile Asp Phe Gly Asp Lys Gln Ser Leu Thr Val Gly Lys Val Thr Ser 
            900                 905                 910         


Tyr Ile Ile Asn Asn Leu Gln Pro Asp Thr Thr Tyr Arg Ile Arg Ile 
        915                 920                 925             


Gln Ala Leu Asn Ser Leu Gly Ala Gly Pro Phe Ser His Met Ile Lys 
    930                 935                 940                 


Leu Lys Thr Lys Pro Leu Pro Pro Asp Pro Pro Arg Leu Glu Cys Val 
945                 950                 955                 960 


Ala Phe Ser His Gln Asn Leu Lys Leu Lys Trp Gly Glu Gly Thr Pro 
                965                 970                 975     


Lys Thr Leu Ser Thr Asp Ser Ile Gln Tyr His Leu Gln Met Glu Asp 
            980                 985                 990         


Lys Asn Gly Arg Phe Val Ser Leu  Tyr Arg Gly Pro Cys  His Thr Tyr 
        995                 1000                 1005             


Lys Val  Gln Arg Leu Asn Glu  Ser Thr Ser Tyr Lys  Phe Cys Ile 
    1010                 1015                 1020             


Gln Ala  Cys Asn Glu Ala Gly  Glu Gly Pro Leu Ser  Gln Glu Tyr 
    1025                 1030                 1035             


Ile Phe  Thr Thr Pro Lys Ser  Val Pro Ala Ala Leu  Lys Ala Pro 
    1040                 1045                 1050             


Lys Ile  Glu Lys Val Asn Asp  His Ile Cys Glu Ile  Thr Trp Glu 
    1055                 1060                 1065             


Cys Leu  Gln Pro Met Lys Gly  Asp Pro Val Ile Tyr  Ser Leu Gln 
    1070                 1075                 1080             


Val Met  Leu Gly Lys Asp Ser  Glu Phe Lys Gln Ile  Tyr Lys Gly 
    1085                 1090                 1095             


Pro Asp  Ser Ser Phe Arg Tyr  Ser Ser Leu Gln Leu  Asn Cys Glu 
    1100                 1105                 1110             


Tyr Arg  Phe Arg Val Cys Ala  Ile Arg Gln Cys Gln  Asp Ser Leu 
    1115                 1120                 1125             


Gly His  Gln Asp Leu Val Gly  Pro Tyr Ser Thr Thr  Val Leu Phe 
    1130                 1135                 1140             


Ile Ser  Gln Arg Thr Glu Pro  Pro Ala Ser Thr Asn  Arg Asp Thr 
    1145                 1150                 1155             


Val Glu  Ser Thr Arg Thr Arg  Arg Ala Leu Ser Asp  Glu Gln Cys 
    1160                 1165                 1170             


Ala Ala  Val Ile Leu Val Leu  Phe Ala Phe Phe Ser  Ile Leu Ile 
    1175                 1180                 1185             


Ala Phe  Ile Ile Gln Tyr Phe  Val Ile Lys 
    1190                 1195             


<210>  992
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  992

Met Glu Ser Thr Ser Gln Asp Arg Arg Ala Thr His Val Ile Thr Ile 
1               5                   10                  15      


Lys Pro Asn Glu Thr Val Leu Thr Ala Phe Pro Tyr Arg Pro His Ser 
            20                  25                  30          


Ser Leu Leu Asp Phe Leu Lys Gly Glu Pro Arg Val Leu Gly Ala Thr 
        35                  40                  45              


Gln Ile Leu Leu Ala Leu Ile Ile Val Gly Phe Gly Thr Ile Phe Ala 
    50                  55                  60                  


Leu Asn Tyr Ile Gly Phe Ser Gln Arg Leu Pro Leu Val Val Leu Thr 
65                  70                  75                  80  


Gly Tyr Pro Phe Trp Gly Ala Leu Ile Gly Gln Gly Val Thr Gly Met 
                85                  90                  95      


Asn Val Ile Ser Ser Leu Val Ala Ile Thr Gly Ile Thr Phe Thr Ile 
            100                 105                 110         


Leu Ser Tyr Arg His Gln Asp Lys Tyr Cys Gln Met Pro Ser Phe Glu 
        115                 120                 125             


Glu Ile Cys Val Phe Ser Arg Thr Leu Phe Ile Val Leu Phe Phe Leu 
    130                 135                 140                 


Pro Ser Asp Val Thr Gln Asn Ser Glu Gln Pro Ala Pro Glu Glu Asn 
145                 150                 155                 160 


Asp Gln Leu Gln Phe Val Leu Gln Glu Glu Phe Ser Ser Asp Asp Ser 
                165                 170                 175     


Thr Thr Asn Ala Gln Ser Val Ile Phe Gly Gly Tyr Ala Phe Phe Lys 
            180                 185                 190         


Leu Thr Leu Ser Arg Ser Pro Leu Val Ser Gln Pro Gly Asn Lys Gly 
        195                 200                 205             


Arg Glu Phe Val Pro Asp Glu Gln Lys Gln Ser Ile Leu Pro Ser Pro 
    210                 215                 220                 


Lys Phe Ser Glu Glu Glu Ile Glu Pro Leu Pro Pro Thr Leu Glu Lys 
225                 230                 235                 240 


Lys Pro Ser Glu Asn Met Ser Ile Gln Leu Asp Ser Thr Phe Lys Gln 
                245                 250                 255     


Met Lys Asp Glu Asp Leu Gln Ser Ala Ile Val Gln Pro Ser Gln Met 
            260                 265                 270         


Gln Thr Lys Leu Leu Gln Asp Gln Ala Ala Ser Leu Gln Val Phe Pro 
        275                 280                 285             


Ser His Ser Ala Leu Lys Leu Glu Asp Ile Ser Pro Glu Asp Leu Pro 
    290                 295                 300                 


Ser Gln Ala Leu Pro Val Glu Gly Leu Ser Glu Gln Thr Met Pro Ser 
305                 310                 315                 320 


Lys Ser Thr Ser Ser His Val Lys Gln Ser Ser Asn Leu Thr Ala Asn 
                325                 330                 335     


Asp Leu Pro Pro Gln Gly Ile Leu Ser Gln Asp Thr Ser Ser Gln Asp 
            340                 345                 350         


Met Leu Phe His Asp Met Thr Ser Gln Asp Met Gln Ser Leu Asp Met 
        355                 360                 365             


Leu Ser Gln Asp Thr Pro Ser His Ala Met Pro Pro Gln Asp Ile Pro 
    370                 375                 380                 


Ser Gln Asp Met Leu Ser Gln Ala Leu Ser Ala His Ala Ile Leu Pro 
385                 390                 395                 400 


Glu Ala Ser Thr Ser His Ile Val Gln Phe Pro Glu Ile Gln His Leu 
                405                 410                 415     


Leu Gln Gln Pro Pro Asp Leu Gln Pro Glu Asn Thr Glu Pro Gln Asn 
            420                 425                 430         


Gln Gln Ile Leu Gln Met Ser Tyr Gln Asp Ile Arg Ser Glu Val Met 
        435                 440                 445             


Glu Glu Thr Lys Glu Trp Lys Ser Glu Glu Glu Leu His Arg Arg Lys 
    450                 455                 460                 


Ser Ser Arg Arg His Ser Leu Asn Gln Gln Thr Lys Ala Leu Gln Tyr 
465                 470                 475                 480 


Leu Arg Arg His Ser Leu Asp Val Gln Ala Lys Gly Gln Lys Ser Ser 
                485                 490                 495     


Lys Arg His Ser Leu Asp Gln Gln Ser Lys Gly Trp Gln Ser Pro Lys 
            500                 505                 510         


Gln Lys Ser Leu Asp Gln Gln Ile Lys Asp Trp Leu Ser Pro Lys Arg 
        515                 520                 525             


His Ser Val Asp Lys Gln Ala Gln Leu Asn Gln Thr Lys Glu Gln Leu 
    530                 535                 540                 


Pro Asp Gln Gln Ala Glu Asp Gln Gln Ala Lys Gly Glu Gln Tyr Pro 
545                 550                 555                 560 


Glu Gly Gln Ser Lys Asp Gly Gln Val Lys Asp Gln Gln Thr Asp Lys 
                565                 570                 575     


Glu Gln Asn Ser Lys Lys Gln Thr Gln Asp Gln Gln Thr Glu Asp Gln 
            580                 585                 590         


Pro Ala Gln Glu Lys Lys Ser Pro Lys Gly Gln Phe Gln Asn Val Gln 
        595                 600                 605             


Ala Glu Gly Gln Gln Ala Gln Val Glu Lys Val Pro Lys Leu Leu Cys 
    610                 615                 620                 


Gln Asp Ser Glu Ser Gln Ile Gln Gln Tyr Gln Phe Trp Gln Phe His 
625                 630                 635                 640 


Lys Gly Asn Leu Gln Ala Gly Gln Pro Arg Thr Val Asn Leu Leu Ala 
                645                 650                 655     


Lys Asn Pro Leu Thr Gly 
            660         


<210>  993
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  993

Met Ser Arg Ile Asn Lys Asn Val Val Leu Ala Leu Leu Thr Leu Thr 
1               5                   10                  15      


Ser Ser Ala Phe Leu Leu Phe Gln Leu Tyr Tyr Tyr Lys His Tyr Leu 
            20                  25                  30          


Ser Thr Lys Asn Gly Ala Gly Leu Ser Lys Ser Lys Gly Ser Arg Ile 
        35                  40                  45              


Gly Phe Asp Ser Thr Gln Trp Arg Ala Val Lys Lys Phe Ile Met Leu 
    50                  55                  60                  


Thr Ser Asn Gln Asn Val Pro Val Phe Leu Ile Asp Pro Leu Ile Leu 
65                  70                  75                  80  


Glu Leu Ile Asn Lys Asn Phe Glu Gln Val Lys Asn Thr Ser His Gly 
                85                  90                  95      


Ser Thr Ser Gln Cys Lys Phe Phe Cys Val Pro Arg Asp Phe Thr Ala 
            100                 105                 110         


Phe Ala Leu Gln Tyr His Leu Trp Lys Asn Glu Glu Gly Trp Phe Arg 
        115                 120                 125             


Ile Ala Glu Asn Met Gly Phe Gln Cys Leu Lys Ile Glu Ser Lys Asp 
    130                 135                 140                 


Pro Arg Leu Asp Gly Ile Asp Ser Leu Ser Gly Thr Glu Ile Pro Leu 
145                 150                 155                 160 


His Tyr Ile Cys Lys Leu Ala Thr His Ala Ile His Leu Val Val Phe 
                165                 170                 175     


His Glu Arg Ser Gly Asn Tyr Leu Trp His Gly His Leu Arg Leu Lys 
            180                 185                 190         


Glu His Ile Asp Arg Lys Phe Val Pro Phe Arg Lys Leu Gln Phe Gly 
        195                 200                 205             


Arg Tyr Pro Gly Ala Phe Asp Arg Pro Glu Leu Gln Gln Val Thr Val 
    210                 215                 220                 


Asp Gly Leu Glu Val Leu Ile Pro Lys Asp Pro Met His Phe Val Glu 
225                 230                 235                 240 


Glu Val Pro His Ser Arg Phe Ile Glu Cys Arg Tyr Lys Glu Ala Arg 
                245                 250                 255     


Ala Phe Phe Gln Gln Tyr Leu Asp Asp Asn Thr Val Glu Ala Val Ala 
            260                 265                 270         


Phe Arg Lys Ser Ala Lys Glu Leu Leu Gln Leu Ala Ala Lys Thr Leu 
        275                 280                 285             


Asn Lys Leu Gly Val Pro Phe Trp Leu Ser Ser Gly Thr Cys Leu Gly 
    290                 295                 300                 


Trp Tyr Arg Gln Cys Asn Ile Ile Pro Tyr Ser Lys Asp Val Asp Leu 
305                 310                 315                 320 


Gly Ile Phe Ile Gln Asp Tyr Lys Ser Asp Ile Ile Leu Ala Phe Gln 
                325                 330                 335     


Asp Ala Gly Leu Pro Leu Lys His Lys Phe Gly Lys Val Glu Asp Ser 
            340                 345                 350         


Leu Glu Leu Ser Phe Gln Gly Lys Asp Asp Val Lys Leu Asp Val Phe 
        355                 360                 365             


Phe Phe Tyr Glu Glu Thr Asp His Met Trp Asn Gly Gly Thr Gln Ala 
    370                 375                 380                 


Lys Thr Gly Lys Lys Phe Lys Tyr Leu Phe Pro Lys Phe Thr Leu Cys 
385                 390                 395                 400 


Trp Thr Glu Phe Val Asp Met Lys Val His Val Pro Cys Glu Thr Leu 
                405                 410                 415     


Glu Tyr Ile Glu Ala Asn Tyr Gly Lys Thr Trp Lys Ile Pro Val Lys 
            420                 425                 430         


Thr Trp Asp Trp Lys Arg Ser Pro Pro Asn Val Gln Pro Asn Gly Ile 
        435                 440                 445             


Trp Pro Ile Ser Glu Trp Asp Glu Val Ile Gln Leu Tyr 
    450                 455                 460     


<210>  994
<211>  952
<212>  PRT
<213>  Homo sapiens

<400>  994

Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      


Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile Leu Leu 
            20                  25                  30          


His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val 
        35                  40                  45              


Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly 
    50                  55                  60                  


Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
65                  70                  75                  80  


Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
                85                  90                  95      


Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
            100                 105                 110         


Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
        115                 120                 125             


Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
    130                 135                 140                 


Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
145                 150                 155                 160 


Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
                165                 170                 175     


Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
            180                 185                 190         


Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu 
        195                 200                 205             


Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg 
    210                 215                 220                 


Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
225                 230                 235                 240 


Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
                245                 250                 255     


Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
            260                 265                 270         


Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
        275                 280                 285             


Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
    290                 295                 300                 


Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
305                 310                 315                 320 


Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
                325                 330                 335     


Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
            340                 345                 350         


Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
        355                 360                 365             


Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
    370                 375                 380                 


Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
385                 390                 395                 400 


Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
                405                 410                 415     


Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
            420                 425                 430         


Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
        435                 440                 445             


Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg 
    450                 455                 460                 


Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
465                 470                 475                 480 


Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
                485                 490                 495     


Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
            500                 505                 510         


Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
        515                 520                 525             


Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
    530                 535                 540                 


Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
545                 550                 555                 560 


Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
                565                 570                 575     


Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
            580                 585                 590         


Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
        595                 600                 605             


Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
    610                 615                 620                 


Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
625                 630                 635                 640 


Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
                645                 650                 655     


Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
            660                 665                 670         


Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
        675                 680                 685             


Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
    690                 695                 700                 


Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
705                 710                 715                 720 


Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
                725                 730                 735     


Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
            740                 745                 750         


Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
        755                 760                 765             


Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly 
    770                 775                 780                 


Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
785                 790                 795                 800 


Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
                805                 810                 815     


His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr 
            820                 825                 830         


Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr 
        835                 840                 845             


Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser 
    850                 855                 860                 


Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala 
865                 870                 875                 880 


Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly 
                885                 890                 895     


Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala 
            900                 905                 910         


Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr 
        915                 920                 925             


Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly 
    930                 935                 940                 


Glu Gln Phe Leu Val Ser Trp Cys 
945                 950         


<210>  995
<211>  952
<212>  PRT
<213>  Homo sapiens

<400>  995

Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      


Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile Leu Leu 
            20                  25                  30          


His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val 
        35                  40                  45              


Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly 
    50                  55                  60                  


Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
65                  70                  75                  80  


Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
                85                  90                  95      


Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
            100                 105                 110         


Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
        115                 120                 125             


Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
    130                 135                 140                 


Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
145                 150                 155                 160 


Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
                165                 170                 175     


Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
            180                 185                 190         


Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu 
        195                 200                 205             


Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg 
    210                 215                 220                 


Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
225                 230                 235                 240 


Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
                245                 250                 255     


Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
            260                 265                 270         


Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
        275                 280                 285             


Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
    290                 295                 300                 


Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
305                 310                 315                 320 


Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
                325                 330                 335     


Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
            340                 345                 350         


Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
        355                 360                 365             


Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
    370                 375                 380                 


Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
385                 390                 395                 400 


Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
                405                 410                 415     


Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
            420                 425                 430         


Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
        435                 440                 445             


Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg 
    450                 455                 460                 


Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
465                 470                 475                 480 


Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
                485                 490                 495     


Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
            500                 505                 510         


Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
        515                 520                 525             


Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
    530                 535                 540                 


Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
545                 550                 555                 560 


Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
                565                 570                 575     


Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
            580                 585                 590         


Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
        595                 600                 605             


Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
    610                 615                 620                 


Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
625                 630                 635                 640 


Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
                645                 650                 655     


Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
            660                 665                 670         


Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
        675                 680                 685             


Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
    690                 695                 700                 


Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
705                 710                 715                 720 


Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
                725                 730                 735     


Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
            740                 745                 750         


Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
        755                 760                 765             


Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly 
    770                 775                 780                 


Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
785                 790                 795                 800 


Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
                805                 810                 815     


His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr 
            820                 825                 830         


Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr 
        835                 840                 845             


Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser 
    850                 855                 860                 


Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala 
865                 870                 875                 880 


Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly 
                885                 890                 895     


Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala 
            900                 905                 910         


Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr 
        915                 920                 925             


Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly 
    930                 935                 940                 


Glu Gln Phe Leu Val Ser Trp Cys 
945                 950         


<210>  996
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  996

Met Ala Arg Gly Pro Gly Pro Leu Gly Arg Pro Arg Pro Asp Thr Val 
1               5                   10                  15      


Ala Met Pro Lys Arg Gly Lys Arg Leu Lys Phe Arg Ala His Asp Ala 
            20                  25                  30          


Cys Ser Gly Arg Val Thr Val Ala Asp Tyr Ala Asp Ser Asp Leu Ala 
        35                  40                  45              


Val Val Arg Ser Gly Arg Val Lys Lys Ala Val Ala Asn Ala Val Arg 
    50                  55                  60                  


Gln Glu Val Lys Ser Leu Cys Gly Leu Glu Ala Ser Gln Val Pro Ala 
65                  70                  75                  80  


Glu Glu Ala Leu Ser Gly Ala Gly Glu Pro Tyr Asp Ile Ile Asp Ser 
                85                  90                  95      


Ser Asp Glu Met Asp Ala Gln Glu Glu Asn Ile His Glu Arg Thr Val 
            100                 105                 110         


Ser Arg Lys Lys Lys Ser Lys Arg His Lys Glu Glu Leu Asp Gly Ala 
        115                 120                 125             


Gly Gly Glu Glu Tyr Pro Met Asp Ile Trp Leu Leu Leu Ala Ser Tyr 
    130                 135                 140                 


Ile Arg Pro Glu Asp Ile Val Asn Phe Ser Leu Ile Cys Lys Asn Ala 
145                 150                 155                 160 


Trp Thr Val Thr Cys Thr Ala Ala Phe Trp Thr Arg Leu Tyr Arg Arg 
                165                 170                 175     


His Tyr Thr Leu Asp Ala Ser Leu Pro Leu Arg Leu Arg Pro Glu Ser 
            180                 185                 190         


Met Glu Lys Leu His Cys Leu Arg Ala Cys Val Ile Arg Ser Leu Tyr 
        195                 200                 205             


His Met Tyr Glu Pro Phe Ala Ala Arg Ile Ser Lys Asn Pro Ala Ile 
    210                 215                 220                 


Pro Glu Ser Thr Pro Ser Thr Leu Lys Asn Ser Lys Cys Leu Leu Phe 
225                 230                 235                 240 


Trp Cys Arg Lys Ile Val Gly Asn Arg Gln Glu Pro Met Trp Glu Phe 
                245                 250                 255     


Asn Phe Lys Phe Lys Lys Gln Ser Pro Arg Leu Lys Ser Lys Cys Thr 
            260                 265                 270         


Gly Gly Leu Gln Pro Pro Val Gln Tyr Glu Asp Val His Thr Asn Pro 
        275                 280                 285             


Asp Gln Asp Cys Cys Leu Leu Gln Val Thr Thr Leu Asn Phe Ile Phe 
    290                 295                 300                 


Ile Pro Ile Val Met Gly Met Ile Phe Thr Leu Phe Thr Ile Asn Val 
305                 310                 315                 320 


Ser Thr Asp Met Arg His His Arg Val Arg Leu Val Phe Gln Asp Ser 
                325                 330                 335     


Pro Val His Gly Gly Arg Lys Leu Arg Ser Glu Gln Gly Val Gln Val 
            340                 345                 350         


Ile Leu Asp Pro Val His Ser Val Arg Leu Phe Asp Trp Trp His Pro 
        355                 360                 365             


Gln Tyr Pro Phe Ser Leu Arg Ala 
    370                 375     


<210>  997
<211>  1370
<212>  PRT
<213>  Homo sapiens

<400>  997

Met Ala Thr Gly Gly Arg Arg Gly Ala Ala Ala Ala Pro Leu Leu Val 
1               5                   10                  15      


Ala Val Ala Ala Leu Leu Leu Gly Ala Ala Gly His Leu Tyr Pro Gly 
            20                  25                  30          


Glu Val Cys Pro Gly Met Asp Ile Arg Asn Asn Leu Thr Arg Leu His 
        35                  40                  45              


Glu Leu Glu Asn Cys Ser Val Ile Glu Gly His Leu Gln Ile Leu Leu 
    50                  55                  60                  


Met Phe Lys Thr Arg Pro Glu Asp Phe Arg Asp Leu Ser Phe Pro Lys 
65                  70                  75                  80  


Leu Ile Met Ile Thr Asp Tyr Leu Leu Leu Phe Arg Val Tyr Gly Leu 
                85                  90                  95      


Glu Ser Leu Lys Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Ser 
            100                 105                 110         


Arg Leu Phe Phe Asn Tyr Ala Leu Val Ile Phe Glu Met Val His Leu 
        115                 120                 125             


Lys Glu Leu Gly Leu Tyr Asn Leu Met Asn Ile Thr Arg Gly Ser Val 
    130                 135                 140                 


Arg Ile Glu Lys Asn Asn Glu Leu Cys Tyr Leu Ala Thr Ile Asp Trp 
145                 150                 155                 160 


Ser Arg Ile Leu Asp Ser Val Glu Asp Asn Tyr Ile Val Leu Asn Lys 
                165                 170                 175     


Asp Asp Asn Glu Glu Cys Gly Asp Ile Cys Pro Gly Thr Ala Lys Gly 
            180                 185                 190         


Lys Thr Asn Cys Pro Ala Thr Val Ile Asn Gly Gln Phe Val Glu Arg 
        195                 200                 205             


Cys Trp Thr His Ser His Cys Gln Lys Val Cys Pro Thr Ile Cys Lys 
    210                 215                 220                 


Ser His Gly Cys Thr Ala Glu Gly Leu Cys Cys His Ser Glu Cys Leu 
225                 230                 235                 240 


Gly Asn Cys Ser Gln Pro Asp Asp Pro Thr Lys Cys Val Ala Cys Arg 
                245                 250                 255     


Asn Phe Tyr Leu Asp Gly Arg Cys Val Glu Thr Cys Pro Pro Pro Tyr 
            260                 265                 270         


Tyr His Phe Gln Asp Trp Arg Cys Val Asn Phe Ser Phe Cys Gln Asp 
        275                 280                 285             


Leu His His Lys Cys Lys Asn Ser Arg Arg Gln Gly Cys His Gln Tyr 
    290                 295                 300                 


Val Ile His Asn Asn Lys Cys Ile Pro Glu Cys Pro Ser Gly Tyr Thr 
305                 310                 315                 320 


Met Asn Ser Ser Asn Leu Leu Cys Thr Pro Cys Leu Gly Pro Cys Pro 
                325                 330                 335     


Lys Val Cys His Leu Leu Glu Gly Glu Lys Thr Ile Asp Ser Val Thr 
            340                 345                 350         


Ser Ala Gln Glu Leu Arg Gly Cys Thr Val Ile Asn Gly Ser Leu Ile 
        355                 360                 365             


Ile Asn Ile Arg Gly Gly Asn Asn Leu Ala Ala Glu Leu Glu Ala Asn 
    370                 375                 380                 


Leu Gly Leu Ile Glu Glu Ile Ser Gly Tyr Leu Lys Ile Arg Arg Ser 
385                 390                 395                 400 


Tyr Ala Leu Val Ser Leu Ser Phe Phe Arg Lys Leu Arg Leu Ile Arg 
                405                 410                 415     


Gly Glu Thr Leu Glu Ile Gly Asn Tyr Ser Phe Tyr Ala Leu Asp Asn 
            420                 425                 430         


Gln Asn Leu Arg Gln Leu Trp Asp Trp Ser Lys His Asn Leu Thr Ile 
        435                 440                 445             


Thr Gln Gly Lys Leu Phe Phe His Tyr Asn Pro Lys Leu Cys Leu Ser 
    450                 455                 460                 


Glu Ile His Lys Met Glu Glu Val Ser Gly Thr Lys Gly Arg Gln Glu 
465                 470                 475                 480 


Arg Asn Asp Ile Ala Leu Lys Thr Asn Gly Asp Gln Ala Ser Cys Glu 
                485                 490                 495     


Asn Glu Leu Leu Lys Phe Ser Tyr Ile Arg Thr Ser Phe Asp Lys Ile 
            500                 505                 510         


Leu Leu Arg Trp Glu Pro Tyr Trp Pro Pro Asp Phe Arg Asp Leu Leu 
        515                 520                 525             


Gly Phe Met Leu Phe Tyr Lys Glu Ala Pro Tyr Gln Asn Val Thr Glu 
    530                 535                 540                 


Phe Asp Gly Gln Asp Ala Cys Gly Ser Asn Ser Trp Thr Val Val Asp 
545                 550                 555                 560 


Ile Asp Pro Pro Leu Arg Ser Asn Asp Pro Lys Ser Gln Asn His Pro 
                565                 570                 575     


Gly Trp Leu Met Arg Gly Leu Lys Pro Trp Thr Gln Tyr Ala Ile Phe 
            580                 585                 590         


Val Lys Thr Leu Val Thr Phe Ser Asp Glu Arg Arg Thr Tyr Gly Ala 
        595                 600                 605             


Lys Ser Asp Ile Ile Tyr Val Gln Thr Asp Ala Thr Asn Pro Ser Val 
    610                 615                 620                 


Pro Leu Asp Pro Ile Ser Val Ser Asn Ser Ser Ser Gln Ile Ile Leu 
625                 630                 635                 640 


Lys Trp Lys Pro Pro Ser Asp Pro Asn Gly Asn Ile Thr His Tyr Leu 
                645                 650                 655     


Val Phe Trp Glu Arg Gln Ala Glu Asp Ser Glu Leu Phe Glu Leu Asp 
            660                 665                 670         


Tyr Cys Leu Lys Gly Leu Lys Leu Pro Ser Arg Thr Trp Ser Pro Pro 
        675                 680                 685             


Phe Glu Ser Glu Asp Ser Gln Lys His Asn Gln Ser Glu Tyr Glu Asp 
    690                 695                 700                 


Ser Ala Gly Glu Cys Cys Ser Cys Pro Lys Thr Asp Ser Gln Ile Leu 
705                 710                 715                 720 


Lys Glu Leu Glu Glu Ser Ser Phe Arg Lys Thr Phe Glu Asp Tyr Leu 
                725                 730                 735     


His Asn Val Val Phe Val Pro Arg Pro Ser Arg Lys Arg Arg Ser Leu 
            740                 745                 750         


Gly Asp Val Gly Asn Val Thr Val Ala Val Pro Thr Val Ala Ala Phe 
        755                 760                 765             


Pro Asn Thr Ser Ser Thr Ser Val Pro Thr Ser Pro Glu Glu His Arg 
    770                 775                 780                 


Pro Phe Glu Lys Val Val Asn Lys Glu Ser Leu Val Ile Ser Gly Leu 
785                 790                 795                 800 


Arg His Phe Thr Gly Tyr Arg Ile Glu Leu Gln Ala Cys Asn Gln Asp 
                805                 810                 815     


Thr Pro Glu Glu Arg Cys Ser Val Ala Ala Tyr Val Ser Ala Arg Thr 
            820                 825                 830         


Met Pro Glu Ala Lys Ala Asp Asp Ile Val Gly Pro Val Thr His Glu 
        835                 840                 845             


Ile Phe Glu Asn Asn Val Val His Leu Met Trp Gln Glu Pro Lys Glu 
    850                 855                 860                 


Pro Asn Gly Leu Ile Val Leu Tyr Glu Val Ser Tyr Arg Arg Tyr Gly 
865                 870                 875                 880 


Asp Glu Glu Leu His Leu Cys Val Ser Arg Lys His Phe Ala Leu Glu 
                885                 890                 895     


Arg Gly Cys Arg Leu Arg Gly Leu Ser Pro Gly Asn Tyr Ser Val Arg 
            900                 905                 910         


Ile Arg Ala Thr Ser Leu Ala Gly Asn Gly Ser Trp Thr Glu Pro Thr 
        915                 920                 925             


Tyr Phe Tyr Val Thr Asp Tyr Leu Asp Val Pro Ser Asn Ile Ala Lys 
    930                 935                 940                 


Ile Ile Ile Gly Pro Leu Ile Phe Val Phe Leu Phe Ser Val Val Ile 
945                 950                 955                 960 


Gly Ser Ile Tyr Leu Phe Leu Arg Lys Arg Gln Pro Asp Gly Pro Leu 
                965                 970                 975     


Gly Pro Leu Tyr Ala Ser Ser Asn Pro Glu Tyr Leu Ser Ala Ser Asp 
            980                 985                 990         


Val Phe Pro Cys Ser Val Tyr Val  Pro Asp Glu Trp Glu  Val Ser Arg 
        995                 1000                 1005             


Glu Lys  Ile Thr Leu Leu Arg  Glu Leu Gly Gln Gly  Ser Phe Gly 
    1010                 1015                 1020             


Met Val  Tyr Glu Gly Asn Ala  Arg Asp Ile Ile Lys  Gly Glu Ala 
    1025                 1030                 1035             


Glu Thr  Arg Val Ala Val Lys  Thr Val Asn Glu Ser  Ala Ser Leu 
    1040                 1045                 1050             


Arg Glu  Arg Ile Glu Phe Leu  Asn Glu Ala Ser Val  Met Lys Gly 
    1055                 1060                 1065             


Phe Thr  Cys His His Val Val  Arg Leu Leu Gly Val  Val Ser Lys 
    1070                 1075                 1080             


Gly Gln  Pro Thr Leu Val Val  Met Glu Leu Met Ala  His Gly Asp 
    1085                 1090                 1095             


Leu Lys  Ser Tyr Leu Arg Ser  Leu Arg Pro Glu Ala  Glu Asn Asn 
    1100                 1105                 1110             


Pro Gly  Arg Pro Pro Pro Thr  Leu Gln Glu Met Ile  Gln Met Ala 
    1115                 1120                 1125             


Ala Glu  Ile Ala Asp Gly Met  Ala Tyr Leu Asn Ala  Lys Lys Phe 
    1130                 1135                 1140             


Val His  Arg Asp Leu Ala Ala  Arg Asn Cys Met Val  Ala His Asp 
    1145                 1150                 1155             


Phe Thr  Val Lys Ile Gly Asp  Phe Gly Met Thr Arg  Asp Ile Tyr 
    1160                 1165                 1170             


Glu Thr  Asp Tyr Tyr Arg Lys  Gly Gly Lys Gly Leu  Leu Pro Val 
    1175                 1180                 1185             


Arg Trp  Met Ala Pro Glu Ser  Leu Lys Asp Gly Val  Phe Thr Thr 
    1190                 1195                 1200             


Ser Ser  Asp Met Trp Ser Phe  Gly Val Val Leu Trp  Glu Ile Thr 
    1205                 1210                 1215             


Ser Leu  Ala Glu Gln Pro Tyr  Gln Gly Leu Ser Asn  Glu Gln Val 
    1220                 1225                 1230             


Leu Lys  Phe Val Met Asp Gly  Gly Tyr Leu Asp Gln  Pro Asp Asn 
    1235                 1240                 1245             


Cys Pro  Glu Arg Val Thr Asp  Leu Met Arg Met Cys  Trp Gln Phe 
    1250                 1255                 1260             


Asn Pro  Lys Met Arg Pro Thr  Phe Leu Glu Ile Val  Asn Leu Leu 
    1265                 1270                 1275             


Lys Asp  Asp Leu His Pro Ser  Phe Pro Glu Val Ser  Phe Phe His 
    1280                 1285                 1290             


Ser Glu  Glu Asn Lys Ala Pro  Glu Ser Glu Glu Leu  Glu Met Glu 
    1295                 1300                 1305             


Phe Glu  Asp Met Glu Asn Val  Pro Leu Asp Arg Ser  Ser His Cys 
    1310                 1315                 1320             


Gln Arg  Glu Glu Ala Gly Gly  Arg Asp Gly Gly Ser  Ser Leu Gly 
    1325                 1330                 1335             


Phe Lys  Arg Ser Tyr Glu Glu  His Ile Pro Tyr Thr  His Met Asn 
    1340                 1345                 1350             


Gly Gly  Lys Lys Asn Gly Arg  Ile Leu Thr Leu Pro  Arg Ser Asn 
    1355                 1360                 1365             


Pro Ser  
    1370 


<210>  998
<211>  1091
<212>  PRT
<213>  Homo sapiens

<400>  998

Met Ala Ala Ala Gly Gln Leu Cys Leu Leu Tyr Leu Ser Ala Gly Leu 
1               5                   10                  15      


Leu Ser Arg Leu Gly Ala Ala Phe Asn Leu Asp Thr Arg Glu Asp Asn 
            20                  25                  30          


Val Ile Arg Lys Tyr Gly Asp Pro Gly Ser Leu Phe Gly Phe Ser Leu 
        35                  40                  45              


Ala Met His Trp Gln Leu Gln Pro Glu Asp Lys Arg Leu Leu Leu Val 
    50                  55                  60                  


Gly Ala Pro Arg Ala Glu Ala Leu Pro Leu Gln Arg Ala Asn Arg Thr 
65                  70                  75                  80  


Gly Gly Leu Tyr Ser Cys Asp Ile Thr Ala Arg Gly Pro Cys Thr Arg 
                85                  90                  95      


Ile Glu Phe Asp Asn Asp Ala Asp Pro Thr Ser Glu Ser Lys Glu Asp 
            100                 105                 110         


Gln Trp Met Gly Val Thr Val Gln Ser Gln Gly Pro Gly Gly Lys Val 
        115                 120                 125             


Val Thr Cys Ala His Arg Tyr Glu Lys Arg Gln His Val Asn Thr Lys 
    130                 135                 140                 


Gln Glu Ser Arg Asp Ile Phe Gly Arg Cys Tyr Val Leu Ser Gln Asn 
145                 150                 155                 160 


Leu Arg Ile Glu Asp Asp Met Asp Gly Gly Asp Trp Ser Phe Cys Asp 
                165                 170                 175     


Gly Arg Leu Arg Gly His Glu Lys Phe Gly Ser Cys Gln Gln Gly Val 
            180                 185                 190         


Ala Ala Thr Phe Thr Lys Asp Phe His Tyr Ile Val Phe Gly Ala Pro 
        195                 200                 205             


Gly Thr Tyr Asn Trp Lys Gly Ile Val Arg Val Glu Gln Lys Asn Asn 
    210                 215                 220                 


Thr Phe Phe Asp Met Asn Ile Phe Glu Asp Gly Pro Tyr Glu Val Gly 
225                 230                 235                 240 


Gly Glu Thr Glu His Asp Glu Ser Leu Val Pro Val Pro Ala Asn Ser 
                245                 250                 255     


Tyr Leu Gly Phe Ser Leu Asp Ser Gly Lys Gly Ile Val Ser Lys Asp 
            260                 265                 270         


Glu Ile Thr Phe Val Ser Gly Ala Pro Arg Ala Asn His Ser Gly Ala 
        275                 280                 285             


Val Val Leu Leu Lys Arg Asp Met Lys Ser Ala His Leu Leu Pro Glu 
    290                 295                 300                 


His Ile Phe Asp Gly Glu Gly Leu Ala Ser Ser Phe Gly Tyr Asp Val 
305                 310                 315                 320 


Ala Val Val Asp Leu Asn Lys Asp Gly Trp Gln Asp Ile Val Ile Gly 
                325                 330                 335     


Ala Pro Gln Tyr Phe Asp Arg Asp Gly Glu Val Gly Gly Ala Val Tyr 
            340                 345                 350         


Val Tyr Met Asn Gln Gln Gly Arg Trp Asn Asn Val Lys Pro Ile Arg 
        355                 360                 365             


Leu Asn Gly Thr Lys Asp Ser Met Phe Gly Ile Ala Val Lys Asn Ile 
    370                 375                 380                 


Gly Asp Ile Asn Gln Asp Gly Tyr Pro Asp Ile Ala Val Gly Ala Pro 
385                 390                 395                 400 


Tyr Asp Asp Leu Gly Lys Val Phe Ile Tyr His Gly Ser Ala Asn Gly 
                405                 410                 415     


Ile Asn Thr Lys Pro Thr Gln Val Leu Lys Gly Ile Ser Pro Tyr Phe 
            420                 425                 430         


Gly Tyr Ser Ile Ala Gly Asn Met Asp Leu Asp Arg Asn Ser Tyr Pro 
        435                 440                 445             


Asp Val Ala Val Gly Ser Leu Ser Asp Ser Val Thr Ile Phe Arg Ser 
    450                 455                 460                 


Arg Pro Val Ile Asn Ile Gln Lys Thr Ile Thr Val Thr Pro Asn Arg 
465                 470                 475                 480 


Ile Asp Leu Arg Gln Lys Thr Ala Cys Gly Ala Pro Ser Gly Ile Cys 
                485                 490                 495     


Leu Gln Val Lys Ser Cys Phe Glu Tyr Thr Ala Asn Pro Ala Gly Tyr 
            500                 505                 510         


Asn Pro Ser Ile Ser Ile Val Gly Thr Leu Glu Ala Glu Lys Glu Arg 
        515                 520                 525             


Arg Lys Ser Gly Leu Ser Ser Arg Val Gln Phe Arg Asn Gln Gly Ser 
    530                 535                 540                 


Glu Pro Lys Tyr Thr Gln Glu Leu Thr Leu Lys Arg Gln Lys Gln Lys 
545                 550                 555                 560 


Val Cys Met Glu Glu Thr Leu Trp Leu Gln Asp Asn Ile Arg Asp Lys 
                565                 570                 575     


Leu Arg Pro Ile Pro Ile Thr Ala Ser Val Glu Ile Gln Glu Pro Ser 
            580                 585                 590         


Ser Arg Arg Arg Val Asn Ser Leu Pro Glu Val Leu Pro Ile Leu Asn 
        595                 600                 605             


Ser Asp Glu Pro Lys Thr Ala His Ile Asp Val His Phe Leu Lys Glu 
    610                 615                 620                 


Gly Cys Gly Asp Asp Asn Val Cys Asn Ser Asn Leu Lys Leu Glu Tyr 
625                 630                 635                 640 


Lys Phe Cys Thr Arg Glu Gly Asn Gln Asp Lys Phe Ser Tyr Leu Pro 
                645                 650                 655     


Ile Gln Lys Gly Val Pro Glu Leu Val Leu Lys Asp Gln Lys Asp Ile 
            660                 665                 670         


Ala Leu Glu Ile Thr Val Thr Asn Ser Pro Ser Asn Pro Arg Asn Pro 
        675                 680                 685             


Thr Lys Asp Gly Asp Asp Ala His Glu Ala Lys Leu Ile Ala Thr Phe 
    690                 695                 700                 


Pro Asp Thr Leu Thr Tyr Ser Ala Tyr Arg Glu Leu Arg Ala Phe Pro 
705                 710                 715                 720 


Glu Lys Gln Leu Ser Cys Val Ala Asn Gln Asn Gly Ser Gln Ala Asp 
                725                 730                 735     


Cys Glu Leu Gly Asn Pro Phe Lys Arg Asn Ser Asn Val Thr Phe Tyr 
            740                 745                 750         


Leu Val Leu Ser Thr Thr Glu Val Thr Phe Asp Thr Pro Asp Leu Asp 
        755                 760                 765             


Ile Asn Leu Lys Leu Glu Thr Thr Ser Asn Gln Asp Asn Leu Ala Pro 
    770                 775                 780                 


Ile Thr Ala Lys Ala Lys Val Val Ile Glu Leu Leu Leu Ser Val Ser 
785                 790                 795                 800 


Gly Val Ala Lys Pro Ser Gln Val Tyr Phe Gly Gly Thr Val Val Gly 
                805                 810                 815     


Glu Gln Ala Met Lys Ser Glu Asp Glu Val Gly Ser Leu Ile Glu Tyr 
            820                 825                 830         


Glu Phe Arg Val Ile Asn Leu Gly Lys Pro Leu Thr Asn Leu Gly Thr 
        835                 840                 845             


Ala Thr Leu Asn Ile Gln Trp Pro Lys Glu Ile Ser Asn Gly Lys Trp 
    850                 855                 860                 


Leu Leu Tyr Leu Val Lys Val Glu Ser Lys Gly Leu Glu Lys Val Thr 
865                 870                 875                 880 


Cys Glu Pro Gln Lys Glu Ile Asn Ser Leu Asn Leu Thr Glu Ser His 
                885                 890                 895     


Asn Ser Arg Lys Lys Arg Glu Ile Thr Glu Lys Gln Ile Asp Asp Asn 
            900                 905                 910         


Arg Lys Phe Ser Leu Phe Ala Glu Arg Lys Tyr Gln Thr Leu Asn Cys 
        915                 920                 925             


Ser Val Asn Val Asn Cys Val Asn Ile Arg Cys Pro Leu Arg Gly Leu 
    930                 935                 940                 


Asp Ser Lys Ala Ser Leu Ile Leu Arg Ser Arg Leu Trp Asn Ser Thr 
945                 950                 955                 960 


Phe Leu Glu Glu Tyr Ser Lys Leu Asn Tyr Leu Asp Ile Leu Met Arg 
                965                 970                 975     


Ala Phe Ile Asp Val Thr Ala Ala Ala Glu Asn Ile Arg Leu Pro Asn 
            980                 985                 990         


Ala Gly Thr Gln Val Arg Val Thr  Val Phe Pro Ser Lys  Thr Val Ala 
        995                 1000                 1005             


Gln Tyr  Ser Gly Val Pro Trp  Trp Ile Ile Leu Val  Ala Ile Leu 
    1010                 1015                 1020             


Ala Gly  Ile Leu Met Leu Ala  Leu Leu Val Phe Ile  Leu Trp Lys 
    1025                 1030                 1035             


Cys Gly  Phe Phe Lys Arg Ser  Arg Tyr Asp Asp Ser  Val Pro Arg 
    1040                 1045                 1050             


Tyr His  Ala Val Arg Ile Arg  Lys Glu Glu Arg Glu  Ile Lys Asp 
    1055                 1060                 1065             


Glu Lys  Tyr Ile Asp Asn Leu  Glu Lys Lys Gln Trp  Ile Thr Lys 
    1070                 1075                 1080             


Trp Asn  Glu Asn Glu Ser Tyr  Ser 
    1085                 1090     


<210>  999
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  999

Met Asn Gly Arg Ala Asp Phe Arg Glu Pro Asn Ala Glu Val Pro Arg 
1               5                   10                  15      


Pro Ile Pro His Ile Gly Pro Asp Tyr Ile Pro Thr Glu Glu Glu Arg 
            20                  25                  30          


Arg Val Phe Ala Glu Cys Asn Asp Glu Ser Phe Trp Phe Arg Ser Val 
        35                  40                  45              


Pro Leu Ala Ala Thr Ser Met Leu Ile Thr Gln Gly Leu Ile Ser Lys 
    50                  55                  60                  


Gly Ile Leu Ser Ser His Pro Lys Tyr Gly Ser Ile Pro Lys Leu Ile 
65                  70                  75                  80  


Leu Ala Cys Ile Met Gly Tyr Phe Ala Gly Lys Leu Ser Tyr Val Lys 
                85                  90                  95      


Thr Cys Gln Glu Lys Phe Lys Lys Leu Glu Asn Ser Pro Leu Gly Glu 
            100                 105                 110         


Ala Leu Arg Ser Gly Gln Ala Arg Arg Ser Ser Pro Pro Gly His Tyr 
        115                 120                 125             


Tyr Gln Lys Ser Lys Tyr Asp Ser Ser Val Ser Gly Gln Ser Ser Phe 
    130                 135                 140                 


Val Thr Ser Pro Ala Ala Asp Asn Ile Glu Met Leu Pro His Tyr Glu 
145                 150                 155                 160 


Pro Ile Pro Phe Ser Ser Ser Met Asn Glu Ser Ala Pro Thr Gly Ile 
                165                 170                 175     


Thr Asp His Ile Val Gln Gly Pro Asp Pro Asn Leu Glu Glu Ser Pro 
            180                 185                 190         


Lys Arg Lys Asn Ile Thr Tyr Glu Glu Leu Arg Asn Lys Asn Arg Glu 
        195                 200                 205             


Ser Tyr Glu Val Ser Leu Thr Gln Lys Thr Asp Pro Ser Val Arg Pro 
    210                 215                 220                 


Met His Glu Arg Val Pro Lys Lys Glu Val Lys Val Asn Lys Tyr Gly 
225                 230                 235                 240 


Asp Thr Trp Asp Glu 
                245 


<210>  1000
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  1000

Met Asn Gly Arg Ala Asp Phe Arg Glu Pro Asn Ala Glu Val Pro Arg 
1               5                   10                  15      


Pro Ile Pro His Ile Gly Pro Asp Tyr Ile Pro Thr Glu Glu Glu Arg 
            20                  25                  30          


Arg Val Phe Ala Glu Cys Asn Asp Glu Ser Phe Trp Phe Arg Ser Val 
        35                  40                  45              


Pro Leu Ala Ala Thr Ser Met Leu Ile Thr Gln Gly Leu Ile Ser Lys 
    50                  55                  60                  


Gly Ile Leu Ser Ser His Pro Lys Tyr Gly Ser Ile Pro Lys Leu Ile 
65                  70                  75                  80  


Leu Ala Cys Ile Met Gly Tyr Phe Ala Gly Lys Leu Ser Tyr Val Lys 
                85                  90                  95      


Thr Cys Gln Glu Lys Phe Lys Lys Leu Glu Asn Ser Pro Leu Gly Glu 
            100                 105                 110         


Ala Leu Arg Ser Gly Gln Ala Arg Arg Ser Ser Pro Pro Gly His Tyr 
        115                 120                 125             


Tyr Gln Lys Ser Lys Tyr Asp Ser Ser Val Ser Gly Gln Ser Ser Phe 
    130                 135                 140                 


Val Thr Ser Pro Ala Ala Asp Asn Ile Glu Met Leu Pro His Tyr Glu 
145                 150                 155                 160 


Pro Ile Pro Phe Ser Ser Ser Met Asn Glu Ser Ala Pro Thr Gly Ile 
                165                 170                 175     


Thr Asp His Ile Val Gln Val Lys Val Asn Lys Tyr Gly Asp Thr Trp 
            180                 185                 190         


Asp Glu 
        


<210>  1001
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  1001

Met Asn Gly Arg Ala Asp Phe Arg Glu Pro Asn Ala Glu Val Pro Arg 
1               5                   10                  15      


Pro Ile Pro His Ile Gly Pro Asp Tyr Ile Pro Thr Glu Glu Glu Arg 
            20                  25                  30          


Arg Val Phe Ala Glu Cys Asn Asp Glu Ser Phe Trp Phe Arg Ser Val 
        35                  40                  45              


Pro Leu Ala Ala Thr Ser Met Leu Ile Thr Gln Gly Leu Ile Ser Lys 
    50                  55                  60                  


Gly Ile Leu Ser Ser His Pro Lys Tyr Gly Ser Ile Pro Lys Leu Ile 
65                  70                  75                  80  


Leu Ala Cys Ile Met Gly Tyr Phe Ala Gly Lys Leu Ser Tyr Val Lys 
                85                  90                  95      


Thr Cys Gln Glu Lys Phe Lys Lys Leu Glu Asn Ser Pro Leu Gly Glu 
            100                 105                 110         


Ala Leu Arg Ser Gly Gln Ala Arg Arg Ser Ser Pro Pro Gly His Tyr 
        115                 120                 125             


Tyr Gln Lys Ser Lys Tyr Asp Ser Ser Val Ser Gly Gln Ser Ser Phe 
    130                 135                 140                 


Val Thr Ser Pro Ala Ala Asp Asn Ile Glu Met Leu Pro His Tyr Glu 
145                 150                 155                 160 


Pro Ile Pro Phe Ser Ser Ser Met Asn Glu Ser Ala Pro Thr Gly Ile 
                165                 170                 175     


Thr Asp His Ile Val Gln Gly Arg Asn Phe Ser 
            180                 185         


<210>  1002
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  1002

Met Asn Gly Arg Ala Asp Phe Arg Glu Pro Asn Ala Glu Val Pro Arg 
1               5                   10                  15      


Pro Ile Pro His Ile Gly Pro Asp Tyr Ile Pro Thr Glu Glu Glu Arg 
            20                  25                  30          


Arg Val Phe Ala Glu Cys Asn Asp Glu Ser Phe Trp Phe Arg Ser Val 
        35                  40                  45              


Pro Leu Ala Ala Thr Ser Met Leu Ile Thr Gln Gly Leu Ile Ser Lys 
    50                  55                  60                  


Gly Ile Leu Ser Ser His Pro Lys Tyr Gly Ser Ile Pro Lys Leu Ile 
65                  70                  75                  80  


Leu Ala Cys Ile Met Gly Tyr Phe Ala Gly Lys Leu Ser Tyr Val Lys 
                85                  90                  95      


Thr Cys Gln Glu Lys Phe Lys Lys Leu Glu Asn Ser Pro Leu Gly Glu 
            100                 105                 110         


Ala Leu Arg Ser Gly Gln Ala Arg Arg Ser Ser Pro Pro Gly His Tyr 
        115                 120                 125             


Tyr Gln Lys Ser Lys Tyr Asp Ser Ser Val Ser Gly Gln Ser Ser Phe 
    130                 135                 140                 


Val Thr Ser Pro Ala Ala Asp Asn Ile Glu Met Leu Pro His Tyr Glu 
145                 150                 155                 160 


Pro Ile Pro Phe Ser Ser Ser Met Asn Glu Ser Ala Pro Thr Gly Ile 
                165                 170                 175     


Thr Asp His Ile Val Gln Val Lys Val Asn Lys Tyr Gly Asp Thr Trp 
            180                 185                 190         


Asp Glu 
        


<210>  1003
<211>  1017
<212>  PRT
<213>  Homo sapiens

<400>  1003

Met Val Phe Ser Val Arg Gln Cys Gly His Val Gly Arg Thr Glu Glu 
1               5                   10                  15      


Val Leu Leu Thr Phe Lys Ile Phe Leu Val Ile Ile Cys Leu His Val 
            20                  25                  30          


Val Leu Val Thr Ser Leu Glu Glu Asp Thr Asp Asn Ser Ser Leu Ser 
        35                  40                  45              


Pro Pro Pro Ala Lys Leu Ser Val Val Ser Phe Ala Pro Ser Ser Asn 
    50                  55                  60                  


Gly Thr Pro Glu Val Glu Thr Thr Ser Leu Asn Asp Val Thr Leu Ser 
65                  70                  75                  80  


Leu Leu Pro Ser Asn Glu Thr Glu Lys Thr Lys Ile Thr Ile Val Lys 
                85                  90                  95      


Thr Phe Asn Ala Ser Gly Val Lys Pro Gln Arg Asn Ile Cys Asn Leu 
            100                 105                 110         


Ser Ser Ile Cys Asn Asp Ser Ala Phe Phe Arg Gly Glu Ile Met Phe 
        115                 120                 125             


Gln Tyr Asp Lys Glu Ser Thr Val Pro Gln Asn Gln His Ile Thr Asn 
    130                 135                 140                 


Gly Thr Leu Thr Gly Val Leu Ser Leu Ser Glu Leu Lys Arg Ser Glu 
145                 150                 155                 160 


Leu Asn Lys Thr Leu Gln Thr Leu Ser Glu Thr Tyr Phe Ile Met Cys 
                165                 170                 175     


Ala Thr Ala Glu Ala Gln Ser Thr Leu Asn Cys Thr Phe Thr Ile Lys 
            180                 185                 190         


Leu Asn Asn Thr Met Asn Ala Cys Ala Val Ile Ala Ala Leu Glu Arg 
        195                 200                 205             


Val Lys Ile Arg Pro Met Glu His Cys Cys Cys Ser Val Arg Ile Pro 
    210                 215                 220                 


Cys Pro Ser Ser Pro Glu Glu Leu Glu Lys Leu Gln Cys Asp Leu Gln 
225                 230                 235                 240 


Asp Pro Ile Val Cys Leu Ala Asp His Pro Arg Gly Pro Pro Phe Ser 
                245                 250                 255     


Ser Ser Gln Ser Ile Pro Val Val Pro Arg Ala Thr Val Leu Ser Gln 
            260                 265                 270         


Val Pro Lys Ala Thr Ser Phe Ala Glu Pro Pro Asp Tyr Ser Pro Val 
        275                 280                 285             


Thr His Asn Val Pro Ser Pro Ile Gly Glu Ile Gln Pro Leu Ser Pro 
    290                 295                 300                 


Gln Pro Ser Ala Pro Ile Ala Ser Ser Pro Ala Ile Asp Met Pro Pro 
305                 310                 315                 320 


Gln Ser Glu Thr Ile Ser Ser Pro Met Pro Gln Thr His Val Ser Gly 
                325                 330                 335     


Thr Pro Pro Pro Val Lys Ala Ser Phe Ser Ser Pro Thr Val Ser Ala 
            340                 345                 350         


Pro Ala Asn Val Asn Thr Thr Ser Ala Pro Pro Val Gln Thr Asp Ile 
        355                 360                 365             


Val Asn Thr Ser Ser Ile Ser Asp Leu Glu Asn Gln Val Leu Gln Met 
    370                 375                 380                 


Glu Lys Ala Leu Ser Leu Gly Ser Leu Glu Pro Asn Leu Ala Gly Glu 
385                 390                 395                 400 


Met Ile Asn Gln Val Ser Arg Leu Leu His Ser Pro Pro Asp Met Leu 
                405                 410                 415     


Ala Pro Leu Ala Gln Arg Leu Leu Lys Val Val Asp Asp Ile Gly Leu 
            420                 425                 430         


Gln Leu Asn Phe Ser Asn Thr Thr Ile Ser Leu Thr Ser Pro Ser Leu 
        435                 440                 445             


Ala Leu Ala Val Ile Arg Val Asn Ala Ser Ser Phe Asn Thr Thr Thr 
    450                 455                 460                 


Phe Val Ala Gln Asp Pro Ala Asn Leu Gln Val Ser Leu Glu Thr Gln 
465                 470                 475                 480 


Ala Pro Glu Asn Ser Ile Gly Thr Ile Thr Leu Pro Ser Ser Leu Met 
                485                 490                 495     


Asn Asn Leu Pro Ala His Asp Met Glu Leu Ala Ser Arg Val Gln Phe 
            500                 505                 510         


Asn Phe Phe Glu Thr Pro Ala Leu Phe Gln Asp Pro Ser Leu Glu Asn 
        515                 520                 525             


Leu Ser Leu Ile Ser Tyr Val Ile Ser Ser Ser Val Ala Asn Leu Thr 
    530                 535                 540                 


Val Arg Asn Leu Thr Arg Asn Val Thr Val Thr Leu Lys His Ile Asn 
545                 550                 555                 560 


Pro Ser Gln Asp Glu Leu Thr Val Arg Cys Val Phe Trp Asp Leu Gly 
                565                 570                 575     


Arg Asn Gly Gly Arg Gly Gly Trp Ser Asp Asn Gly Cys Ser Val Lys 
            580                 585                 590         


Asp Arg Arg Leu Asn Glu Thr Ile Cys Thr Cys Ser His Leu Thr Ser 
        595                 600                 605             


Phe Gly Val Leu Leu Asp Leu Ser Arg Thr Ser Val Leu Pro Ala Gln 
    610                 615                 620                 


Met Met Ala Leu Thr Phe Ile Thr Tyr Ile Gly Cys Gly Leu Ser Ser 
625                 630                 635                 640 


Ile Phe Leu Ser Val Thr Leu Val Thr Tyr Ile Ala Phe Glu Lys Ile 
                645                 650                 655     


Arg Arg Asp Tyr Pro Ser Lys Ile Leu Ile Gln Leu Cys Ala Ala Leu 
            660                 665                 670         


Leu Leu Leu Asn Leu Val Phe Leu Leu Asp Ser Trp Ile Ala Leu Tyr 
        675                 680                 685             


Lys Met Gln Gly Leu Cys Ile Ser Val Ala Val Phe Leu His Tyr Phe 
    690                 695                 700                 


Leu Leu Val Ser Phe Thr Trp Met Gly Leu Glu Ala Phe His Met Tyr 
705                 710                 715                 720 


Leu Ala Leu Val Lys Val Phe Asn Thr Tyr Ile Arg Lys Tyr Ile Leu 
                725                 730                 735     


Lys Phe Cys Ile Val Gly Trp Gly Val Pro Ala Val Val Val Thr Ile 
            740                 745                 750         


Ile Leu Thr Ile Ser Pro Asp Asn Tyr Gly Leu Gly Ser Tyr Gly Lys 
        755                 760                 765             


Phe Pro Asn Gly Ser Pro Asp Asp Phe Cys Trp Ile Asn Asn Asn Ala 
    770                 775                 780                 


Val Phe Tyr Ile Thr Val Val Gly Tyr Phe Cys Val Ile Phe Leu Leu 
785                 790                 795                 800 


Asn Val Ser Met Phe Ile Val Val Leu Val Gln Leu Cys Arg Ile Lys 
                805                 810                 815     


Lys Lys Lys Gln Leu Gly Ala Gln Arg Lys Thr Ser Ile Gln Asp Leu 
            820                 825                 830         


Arg Ser Ile Ala Gly Leu Thr Phe Leu Leu Gly Ile Thr Trp Gly Phe 
        835                 840                 845             


Ala Phe Phe Ala Trp Gly Pro Val Asn Val Thr Phe Met Tyr Leu Phe 
    850                 855                 860                 


Ala Ile Phe Asn Thr Leu Gln Gly Phe Phe Ile Phe Ile Phe Tyr Cys 
865                 870                 875                 880 


Val Ala Lys Glu Asn Val Arg Lys Gln Trp Arg Arg Tyr Leu Cys Cys 
                885                 890                 895     


Gly Lys Leu Arg Leu Ala Glu Asn Ser Asp Trp Ser Lys Thr Ala Thr 
            900                 905                 910         


Asn Gly Leu Lys Lys Gln Thr Val Asn Gln Gly Val Ser Ser Ser Ser 
        915                 920                 925             


Asn Ser Leu Gln Ser Ser Ser Asn Ser Thr Asn Ser Thr Thr Leu Leu 
    930                 935                 940                 


Val Asn Asn Asp Cys Ser Val His Ala Ser Gly Asn Gly Asn Ala Ser 
945                 950                 955                 960 


Thr Glu Arg Asn Gly Val Ser Phe Ser Val Gln Asn Gly Asp Val Cys 
                965                 970                 975     


Leu His Asp Phe Thr Gly Lys Gln His Met Phe Asn Glu Lys Glu Asp 
            980                 985                 990         


Ser Cys Asn Gly Lys Gly Arg Met  Ala Leu Arg Arg Thr  Ser Lys Arg 
        995                 1000                 1005             


Gly Ser  Leu His Phe Ile Glu  Gln Met 
    1010                 1015         


<210>  1004
<211>  1003
<212>  PRT
<213>  Homo sapiens

<400>  1004

Met Val Phe Ser Val Arg Gln Cys Gly His Val Gly Arg Thr Glu Glu 
1               5                   10                  15      


Val Leu Leu Thr Phe Lys Ile Phe Leu Val Ile Ile Cys Leu His Val 
            20                  25                  30          


Val Leu Val Thr Ser Leu Glu Glu Asp Thr Asp Asn Ser Ser Leu Ser 
        35                  40                  45              


Pro Pro Pro Ala Lys Leu Ser Val Val Ser Phe Ala Pro Ser Ser Asn 
    50                  55                  60                  


Gly Thr Pro Glu Val Glu Thr Thr Ser Leu Asn Asp Val Thr Leu Ser 
65                  70                  75                  80  


Leu Leu Pro Ser Asn Glu Thr Gly Val Lys Pro Gln Arg Asn Ile Cys 
                85                  90                  95      


Asn Leu Ser Ser Ile Cys Asn Asp Ser Ala Phe Phe Arg Gly Glu Ile 
            100                 105                 110         


Met Phe Gln Tyr Asp Lys Glu Ser Thr Val Pro Gln Asn Gln His Ile 
        115                 120                 125             


Thr Asn Gly Thr Leu Thr Gly Val Leu Ser Leu Ser Glu Leu Lys Arg 
    130                 135                 140                 


Ser Glu Leu Asn Lys Thr Leu Gln Thr Leu Ser Glu Thr Tyr Phe Ile 
145                 150                 155                 160 


Met Cys Ala Thr Ala Glu Ala Gln Ser Thr Leu Asn Cys Thr Phe Thr 
                165                 170                 175     


Ile Lys Leu Asn Asn Thr Met Asn Ala Cys Ala Val Ile Ala Ala Leu 
            180                 185                 190         


Glu Arg Val Lys Ile Arg Pro Met Glu His Cys Cys Cys Ser Val Arg 
        195                 200                 205             


Ile Pro Cys Pro Ser Ser Pro Glu Glu Leu Glu Lys Leu Gln Cys Asp 
    210                 215                 220                 


Leu Gln Asp Pro Ile Val Cys Leu Ala Asp His Pro Arg Gly Pro Pro 
225                 230                 235                 240 


Phe Ser Ser Ser Gln Ser Ile Pro Val Val Pro Arg Ala Thr Val Leu 
                245                 250                 255     


Ser Gln Val Pro Lys Ala Thr Ser Phe Ala Glu Pro Pro Asp Tyr Ser 
            260                 265                 270         


Pro Val Thr His Asn Val Pro Ser Pro Ile Gly Glu Ile Gln Pro Leu 
        275                 280                 285             


Ser Pro Gln Pro Ser Ala Pro Ile Ala Ser Ser Pro Ala Ile Asp Met 
    290                 295                 300                 


Pro Pro Gln Ser Glu Thr Ile Ser Ser Pro Met Pro Gln Thr His Val 
305                 310                 315                 320 


Ser Gly Thr Pro Pro Pro Val Lys Ala Ser Phe Ser Ser Pro Thr Val 
                325                 330                 335     


Ser Ala Pro Ala Asn Val Asn Thr Thr Ser Ala Pro Pro Val Gln Thr 
            340                 345                 350         


Asp Ile Val Asn Thr Ser Ser Ile Ser Asp Leu Glu Asn Gln Val Leu 
        355                 360                 365             


Gln Met Glu Lys Ala Leu Ser Leu Gly Ser Leu Glu Pro Asn Leu Ala 
    370                 375                 380                 


Gly Glu Met Ile Asn Gln Val Ser Arg Leu Leu His Ser Pro Pro Asp 
385                 390                 395                 400 


Met Leu Ala Pro Leu Ala Gln Arg Leu Leu Lys Val Val Asp Asp Ile 
                405                 410                 415     


Gly Leu Gln Leu Asn Phe Ser Asn Thr Thr Ile Ser Leu Thr Ser Pro 
            420                 425                 430         


Ser Leu Ala Leu Ala Val Ile Arg Val Asn Ala Ser Ser Phe Asn Thr 
        435                 440                 445             


Thr Thr Phe Val Ala Gln Asp Pro Ala Asn Leu Gln Val Ser Leu Glu 
    450                 455                 460                 


Thr Gln Ala Pro Glu Asn Ser Ile Gly Thr Ile Thr Leu Pro Ser Ser 
465                 470                 475                 480 


Leu Met Asn Asn Leu Pro Ala His Asp Met Glu Leu Ala Ser Arg Val 
                485                 490                 495     


Gln Phe Asn Phe Phe Glu Thr Pro Ala Leu Phe Gln Asp Pro Ser Leu 
            500                 505                 510         


Glu Asn Leu Ser Leu Ile Ser Tyr Val Ile Ser Ser Ser Val Ala Asn 
        515                 520                 525             


Leu Thr Val Arg Asn Leu Thr Arg Asn Val Thr Val Thr Leu Lys His 
    530                 535                 540                 


Ile Asn Pro Ser Gln Asp Glu Leu Thr Val Arg Cys Val Phe Trp Asp 
545                 550                 555                 560 


Leu Gly Arg Asn Gly Gly Arg Gly Gly Trp Ser Asp Asn Gly Cys Ser 
                565                 570                 575     


Val Lys Asp Arg Arg Leu Asn Glu Thr Ile Cys Thr Cys Ser His Leu 
            580                 585                 590         


Thr Ser Phe Gly Val Leu Leu Asp Leu Ser Arg Thr Ser Val Leu Pro 
        595                 600                 605             


Ala Gln Met Met Ala Leu Thr Phe Ile Thr Tyr Ile Gly Cys Gly Leu 
    610                 615                 620                 


Ser Ser Ile Phe Leu Ser Val Thr Leu Val Thr Tyr Ile Ala Phe Glu 
625                 630                 635                 640 


Lys Ile Arg Arg Asp Tyr Pro Ser Lys Ile Leu Ile Gln Leu Cys Ala 
                645                 650                 655     


Ala Leu Leu Leu Leu Asn Leu Val Phe Leu Leu Asp Ser Trp Ile Ala 
            660                 665                 670         


Leu Tyr Lys Met Gln Gly Leu Cys Ile Ser Val Ala Val Phe Leu His 
        675                 680                 685             


Tyr Phe Leu Leu Val Ser Phe Thr Trp Met Gly Leu Glu Ala Phe His 
    690                 695                 700                 


Met Tyr Leu Ala Leu Val Lys Val Phe Asn Thr Tyr Ile Arg Lys Tyr 
705                 710                 715                 720 


Ile Leu Lys Phe Cys Ile Val Gly Trp Gly Val Pro Ala Val Val Val 
                725                 730                 735     


Thr Ile Ile Leu Thr Ile Ser Pro Asp Asn Tyr Gly Leu Gly Ser Tyr 
            740                 745                 750         


Gly Lys Phe Pro Asn Gly Ser Pro Asp Asp Phe Cys Trp Ile Asn Asn 
        755                 760                 765             


Asn Ala Val Phe Tyr Ile Thr Val Val Gly Tyr Phe Cys Val Ile Phe 
    770                 775                 780                 


Leu Leu Asn Val Ser Met Phe Ile Val Val Leu Val Gln Leu Cys Arg 
785                 790                 795                 800 


Ile Lys Lys Lys Lys Gln Leu Gly Ala Gln Arg Lys Thr Ser Ile Gln 
                805                 810                 815     


Asp Leu Arg Ser Ile Ala Gly Leu Thr Phe Leu Leu Gly Ile Thr Trp 
            820                 825                 830         


Gly Phe Ala Phe Phe Ala Trp Gly Pro Val Asn Val Thr Phe Met Tyr 
        835                 840                 845             


Leu Phe Ala Ile Phe Asn Thr Leu Gln Gly Phe Phe Ile Phe Ile Phe 
    850                 855                 860                 


Tyr Cys Val Ala Lys Glu Asn Val Arg Lys Gln Trp Arg Arg Tyr Leu 
865                 870                 875                 880 


Cys Cys Gly Lys Leu Arg Leu Ala Glu Asn Ser Asp Trp Ser Lys Thr 
                885                 890                 895     


Ala Thr Asn Gly Leu Lys Lys Gln Thr Val Asn Gln Gly Val Ser Ser 
            900                 905                 910         


Ser Ser Asn Ser Leu Gln Ser Ser Ser Asn Ser Thr Asn Ser Thr Thr 
        915                 920                 925             


Leu Leu Val Asn Asn Asp Cys Ser Val His Ala Ser Gly Asn Gly Asn 
    930                 935                 940                 


Ala Ser Thr Glu Arg Asn Gly Val Ser Phe Ser Val Gln Asn Gly Asp 
945                 950                 955                 960 


Val Cys Leu His Asp Phe Thr Gly Lys Gln His Met Phe Asn Glu Lys 
                965                 970                 975     


Glu Asp Ser Cys Asn Gly Lys Gly Arg Met Ala Leu Arg Arg Thr Ser 
            980                 985                 990         


Lys Arg Gly Ser Leu His Phe Ile  Glu Gln Met 
        995                 1000             


<210>  1005
<211>  995
<212>  PRT
<213>  Homo sapiens

<400>  1005

Met Val Phe Ser Val Arg Gln Cys Gly His Val Gly Arg Thr Glu Glu 
1               5                   10                  15      


Val Leu Leu Thr Phe Lys Ile Phe Leu Val Ile Ile Cys Leu His Val 
            20                  25                  30          


Val Leu Val Thr Ser Leu Glu Glu Asp Thr Asp Asn Ser Ser Leu Ser 
        35                  40                  45              


Pro Pro Pro Ala Lys Leu Ser Val Val Ser Phe Ala Pro Ser Ser Asn 
    50                  55                  60                  


Gly Thr Pro Asp Val Thr Leu Ser Leu Leu Pro Ser Asn Glu Thr Gly 
65                  70                  75                  80  


Val Lys Pro Gln Arg Asn Ile Cys Asn Leu Ser Ser Ile Cys Asn Asp 
                85                  90                  95      


Ser Ala Phe Phe Arg Gly Glu Ile Met Phe Gln Tyr Asp Lys Glu Ser 
            100                 105                 110         


Thr Val Pro Gln Asn Gln His Ile Thr Asn Gly Thr Leu Thr Gly Val 
        115                 120                 125             


Leu Ser Leu Ser Glu Leu Lys Arg Ser Glu Leu Asn Lys Thr Leu Gln 
    130                 135                 140                 


Thr Leu Ser Glu Thr Tyr Phe Ile Met Cys Ala Thr Ala Glu Ala Gln 
145                 150                 155                 160 


Ser Thr Leu Asn Cys Thr Phe Thr Ile Lys Leu Asn Asn Thr Met Asn 
                165                 170                 175     


Ala Cys Ala Val Ile Ala Ala Leu Glu Arg Val Lys Ile Arg Pro Met 
            180                 185                 190         


Glu His Cys Cys Cys Ser Val Arg Ile Pro Cys Pro Ser Ser Pro Glu 
        195                 200                 205             


Glu Leu Glu Lys Leu Gln Cys Asp Leu Gln Asp Pro Ile Val Cys Leu 
    210                 215                 220                 


Ala Asp His Pro Arg Gly Pro Pro Phe Ser Ser Ser Gln Ser Ile Pro 
225                 230                 235                 240 


Val Val Pro Arg Ala Thr Val Leu Ser Gln Val Pro Lys Ala Thr Ser 
                245                 250                 255     


Phe Ala Glu Pro Pro Asp Tyr Ser Pro Val Thr His Asn Val Pro Ser 
            260                 265                 270         


Pro Ile Gly Glu Ile Gln Pro Leu Ser Pro Gln Pro Ser Ala Pro Ile 
        275                 280                 285             


Ala Ser Ser Pro Ala Ile Asp Met Pro Pro Gln Ser Glu Thr Ile Ser 
    290                 295                 300                 


Ser Pro Met Pro Gln Thr His Val Ser Gly Thr Pro Pro Pro Val Lys 
305                 310                 315                 320 


Ala Ser Phe Ser Ser Pro Thr Val Ser Ala Pro Ala Asn Val Asn Thr 
                325                 330                 335     


Thr Ser Ala Pro Pro Val Gln Thr Asp Ile Val Asn Thr Ser Ser Ile 
            340                 345                 350         


Ser Asp Leu Glu Asn Gln Val Leu Gln Met Glu Lys Ala Leu Ser Leu 
        355                 360                 365             


Gly Ser Leu Glu Pro Asn Leu Ala Gly Glu Met Ile Asn Gln Val Ser 
    370                 375                 380                 


Arg Leu Leu His Ser Pro Pro Asp Met Leu Ala Pro Leu Ala Gln Arg 
385                 390                 395                 400 


Leu Leu Lys Val Val Asp Asp Ile Gly Leu Gln Leu Asn Phe Ser Asn 
                405                 410                 415     


Thr Thr Ile Ser Leu Thr Ser Pro Ser Leu Ala Leu Ala Val Ile Arg 
            420                 425                 430         


Val Asn Ala Ser Ser Phe Asn Thr Thr Thr Phe Val Ala Gln Asp Pro 
        435                 440                 445             


Ala Asn Leu Gln Val Ser Leu Glu Thr Gln Ala Pro Glu Asn Ser Ile 
    450                 455                 460                 


Gly Thr Ile Thr Leu Pro Ser Ser Leu Met Asn Asn Leu Pro Ala His 
465                 470                 475                 480 


Asp Met Glu Leu Ala Ser Arg Val Gln Phe Asn Phe Phe Glu Thr Pro 
                485                 490                 495     


Ala Leu Phe Gln Asp Pro Ser Leu Glu Asn Leu Ser Leu Ile Ser Tyr 
            500                 505                 510         


Val Ile Ser Ser Ser Val Ala Asn Leu Thr Val Arg Asn Leu Thr Arg 
        515                 520                 525             


Asn Val Thr Val Thr Leu Lys His Ile Asn Pro Ser Gln Asp Glu Leu 
    530                 535                 540                 


Thr Val Arg Cys Val Phe Trp Asp Leu Gly Arg Asn Gly Gly Arg Gly 
545                 550                 555                 560 


Gly Trp Ser Asp Asn Gly Cys Ser Val Lys Asp Arg Arg Leu Asn Glu 
                565                 570                 575     


Thr Ile Cys Thr Cys Ser His Leu Thr Ser Phe Gly Val Leu Leu Asp 
            580                 585                 590         


Leu Ser Arg Thr Ser Val Leu Pro Ala Gln Met Met Ala Leu Thr Phe 
        595                 600                 605             


Ile Thr Tyr Ile Gly Cys Gly Leu Ser Ser Ile Phe Leu Ser Val Thr 
    610                 615                 620                 


Leu Val Thr Tyr Ile Ala Phe Glu Lys Ile Arg Arg Asp Tyr Pro Ser 
625                 630                 635                 640 


Lys Ile Leu Ile Gln Leu Cys Ala Ala Leu Leu Leu Leu Asn Leu Val 
                645                 650                 655     


Phe Leu Leu Asp Ser Trp Ile Ala Leu Tyr Lys Met Gln Gly Leu Cys 
            660                 665                 670         


Ile Ser Val Ala Val Phe Leu His Tyr Phe Leu Leu Val Ser Phe Thr 
        675                 680                 685             


Trp Met Gly Leu Glu Ala Phe His Met Tyr Leu Ala Leu Val Lys Val 
    690                 695                 700                 


Phe Asn Thr Tyr Ile Arg Lys Tyr Ile Leu Lys Phe Cys Ile Val Gly 
705                 710                 715                 720 


Trp Gly Val Pro Ala Val Val Val Thr Ile Ile Leu Thr Ile Ser Pro 
                725                 730                 735     


Asp Asn Tyr Gly Leu Gly Ser Tyr Gly Lys Phe Pro Asn Gly Ser Pro 
            740                 745                 750         


Asp Asp Phe Cys Trp Ile Asn Asn Asn Ala Val Phe Tyr Ile Thr Val 
        755                 760                 765             


Val Gly Tyr Phe Cys Val Ile Phe Leu Leu Asn Val Ser Met Phe Ile 
    770                 775                 780                 


Val Val Leu Val Gln Leu Cys Arg Ile Lys Lys Lys Lys Gln Leu Gly 
785                 790                 795                 800 


Ala Gln Arg Lys Thr Ser Ile Gln Asp Leu Arg Ser Ile Ala Gly Leu 
                805                 810                 815     


Thr Phe Leu Leu Gly Ile Thr Trp Gly Phe Ala Phe Phe Ala Trp Gly 
            820                 825                 830         


Pro Val Asn Val Thr Phe Met Tyr Leu Phe Ala Ile Phe Asn Thr Leu 
        835                 840                 845             


Gln Gly Phe Phe Ile Phe Ile Phe Tyr Cys Val Ala Lys Glu Asn Val 
    850                 855                 860                 


Arg Lys Gln Trp Arg Arg Tyr Leu Cys Cys Gly Lys Leu Arg Leu Ala 
865                 870                 875                 880 


Glu Asn Ser Asp Trp Ser Lys Thr Ala Thr Asn Gly Leu Lys Lys Gln 
                885                 890                 895     


Thr Val Asn Gln Gly Val Ser Ser Ser Ser Asn Ser Leu Gln Ser Ser 
            900                 905                 910         


Ser Asn Ser Thr Asn Ser Thr Thr Leu Leu Val Asn Asn Asp Cys Ser 
        915                 920                 925             


Val His Ala Ser Gly Asn Gly Asn Ala Ser Thr Glu Arg Asn Gly Val 
    930                 935                 940                 


Ser Phe Ser Val Gln Asn Gly Asp Val Cys Leu His Asp Phe Thr Gly 
945                 950                 955                 960 


Lys Gln His Met Phe Asn Glu Lys Glu Asp Ser Cys Asn Gly Lys Gly 
                965                 970                 975     


Arg Met Ala Leu Arg Arg Thr Ser Lys Arg Gly Ser Leu His Phe Ile 
            980                 985                 990         


Glu Gln Met 
        995 


<210>  1006
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  1006

Met Ser Gln Ala Glu Phe Glu Lys Ala Ala Glu Glu Val Arg His Leu 
1               5                   10                  15      


Lys Thr Lys Pro Ser Asp Glu Glu Met Leu Phe Ile Tyr Gly His Tyr 
            20                  25                  30          


Lys Gln Ala Thr Val Gly Asp Ile Asn Thr Glu Arg Pro Gly Met Leu 
        35                  40                  45              


Asp Phe Thr Gly Lys Ala Lys Trp Asp Ala Trp Asn Glu Leu Lys Gly 
    50                  55                  60                  


Thr Ser Lys Glu Asp Ala Met Lys Ala Tyr Ile Asn Lys Val Glu Glu 
65                  70                  75                  80  


Leu Lys Lys Lys Tyr Gly Ile 
                85          


<210>  1007
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  1007

Met Pro Ala Phe Ala Glu Phe Glu Lys Ala Ala Glu Glu Val Arg His 
1               5                   10                  15      


Leu Lys Thr Lys Pro Ser Asp Glu Glu Met Leu Phe Ile Tyr Gly His 
            20                  25                  30          


Tyr Lys Gln Ala Thr Val Gly Asp Ile Asn Thr Glu Arg Pro Gly Met 
        35                  40                  45              


Leu Asp Phe Thr Gly Lys Ala Lys Trp Asp Ala Trp Asn Glu Leu Lys 
    50                  55                  60                  


Gly Thr Ser Lys Glu Asp Ala Met Lys Ala Tyr Ile Asn Lys Val Glu 
65                  70                  75                  80  


Glu Leu Lys Lys Lys Tyr Gly Ile 
                85              


<210>  1008
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  1008

Met Pro Leu Ser Asp Phe Ile Leu Ala Leu Lys Asp Asn Pro Tyr Phe 
1               5                   10                  15      


Gly Ala Gly Phe Gly Leu Val Gly Val Gly Thr Ala Leu Ala Leu Ala 
            20                  25                  30          


Arg Lys Gly Val Gln Leu Gly Leu Val Ala Phe Arg Arg His Tyr Met 
        35                  40                  45              


Ile Thr Leu Glu Val Pro Ala Arg Asp Arg Ser Tyr Ala Trp Leu Leu 
    50                  55                  60                  


Ser Trp Leu Thr Arg His Ser Thr Arg Thr Gln His Leu Ser Val Glu 
65                  70                  75                  80  


Thr Ser Tyr Leu Gln His Glu Ser Gly Arg Ile Ser Thr Lys Phe Glu 
                85                  90                  95      


Phe Val Pro Ser Pro Gly Asn His Phe Ile Trp Tyr Arg Gly Lys Trp 
            100                 105                 110         


Ile Arg Val Glu Arg Ser Arg Glu Met Gln Met Ile Asp Leu Gln Thr 
        115                 120                 125             


Gly Thr Pro Trp Glu Ser Val Thr Phe Thr Ala Leu Gly Thr Asp Arg 
    130                 135                 140                 


Lys Val Phe Phe Asn Ile Leu Glu Glu Ala Arg Glu Leu Ala Leu Gln 
145                 150                 155                 160 


Gln Glu Glu Gly Lys Thr Val Met Tyr Thr Ala Val Gly Ser Glu Trp 
                165                 170                 175     


Arg Pro Phe Gly Tyr Pro Arg Arg Arg Arg Pro Leu Asn Ser Val Val 
            180                 185                 190         


Leu Gln Gln Gly Leu Ala Asp Arg Ile Val Arg Asp Val Gln Glu Phe 
        195                 200                 205             


Ile Asp Asn Pro Lys Trp Tyr Thr Asp Arg Gly Ile Pro Tyr Arg Arg 
    210                 215                 220                 


Gly Tyr Leu Leu Tyr Gly Pro Pro Gly Cys Gly Lys Ser Ser Phe Ile 
225                 230                 235                 240 


Thr Ala Leu Ala Gly Glu Leu Glu His Ser Ile Cys Leu Leu Ser Leu 
                245                 250                 255     


Thr Asp Ser Ser Leu Ser Asp Asp Arg Leu Asn His Leu Leu Ser Val 
            260                 265                 270         


Ala Pro Gln Gln Ser Leu Val Leu Leu Glu Asp Val Asp Ala Ala Phe 
        275                 280                 285             


Leu Ser Arg Asp Leu Ala Val Glu Asn Pro Val Lys Tyr Gln Gly Leu 
    290                 295                 300                 


Gly Arg Leu Thr Phe Ser Gly Leu Leu Asn Ala Leu Asp Gly Val Ala 
305                 310                 315                 320 


Ser Thr Glu Ala Arg Ile Val Phe Met Thr Thr Asn His Val Asp Arg 
                325                 330                 335     


Leu Asp Pro Ala Leu Ile Arg Pro Gly Arg Val Asp Leu Lys Glu Tyr 
            340                 345                 350         


Val Gly Tyr Cys Ser His Trp Gln Leu Thr Gln Met Phe Gln Arg Phe 
        355                 360                 365             


Tyr Pro Gly Gln Ala Pro Ser Leu Ala Glu Asn Phe Ala Glu His Val 
    370                 375                 380                 


Leu Arg Ala Thr Asn Gln Ile Ser Pro Ala Gln Val Gln Gly Tyr Phe 
385                 390                 395                 400 


Met Leu Tyr Lys Asn Asp Pro Val Gly Ala Ile His Asn Ala Glu Ser 
                405                 410                 415     


Leu Arg Arg 
            


<210>  1009
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  1009

Met Ala Ser Arg Lys Glu Asn Ala Lys Ser Ala Asn Arg Val Leu Arg 
1               5                   10                  15      


Ile Ser Gln Leu Asp Ala Leu Glu Leu Asn Lys Ala Leu Glu Gln Leu 
            20                  25                  30          


Val Trp Ser Gln Phe Thr Gln Cys Phe His Gly Phe Lys Pro Gly Leu 
        35                  40                  45              


Leu Ala Arg Phe Glu Pro Glu Val Lys Ala Cys Leu Trp Val Phe Leu 
    50                  55                  60                  


Trp Arg Phe Thr Ile Tyr Ser Lys Asn Ala Thr Val Gly Gln Ser Val 
65                  70                  75                  80  


Leu Asn Ile Lys Tyr Lys Asn Asp Phe Ser Pro Asn Leu Arg Tyr Gln 
                85                  90                  95      


Pro Pro Ser Lys Asn Gln Lys Ile Trp Tyr Ala Val Cys Thr Ile Gly 
            100                 105                 110         


Gly Arg Trp Leu Glu Glu Arg Cys Tyr Asp Leu Phe Arg Asn His His 
        115                 120                 125             


Leu Ala Ser Phe Gly Lys Val Lys Gln Cys Val Asn Phe Val Ile Gly 
    130                 135                 140                 


Leu Leu Lys Leu Gly Gly Leu Ile Asn Phe Leu Ile Phe Leu Gln Arg 
145                 150                 155                 160 


Gly Lys Phe Ala Thr Leu Thr Glu Arg Leu Leu Gly Ile His Ser Val 
                165                 170                 175     


Phe Cys Lys Pro Gln Asn Ile Arg Glu Val Gly Phe Glu Tyr Met Asn 
            180                 185                 190         


Arg Glu Leu Leu Trp His Gly Phe Ala Glu Phe Leu Ile Phe Leu Leu 
        195                 200                 205             


Pro Leu Ile Asn Val Gln Lys Leu Lys Ala Lys Leu Ser Ser Trp Cys 
    210                 215                 220                 


Ile Pro Leu Thr Gly Ala Pro Asn Ser Asp Asn Thr Leu Ala Thr Ser 
225                 230                 235                 240 


Gly Lys Glu Cys Ala Leu Cys Gly Glu Trp Pro Thr Met Pro His Thr 
                245                 250                 255     


Ile Gly Cys Glu His Ile Phe Cys Tyr Phe Cys Ala Lys Ser Ser Phe 
            260                 265                 270         


Leu Phe Asp Val Tyr Phe Thr Cys Pro Lys Cys Gly Thr Glu Val His 
        275                 280                 285             


Ser Leu Gln Pro Leu Lys Ser Gly Ile Glu Met Ser Glu Val Asn Ala 
    290                 295                 300                 


Leu 
305 


<210>  1010
<211>  676
<212>  PRT
<213>  Homo sapiens

<400>  1010

Met Ala Lys Ile Asn Thr Gln Tyr Ser His Pro Ser Arg Thr His Leu 
1               5                   10                  15      


Lys Val Lys Thr Ser Asp Arg Asp Leu Asn Arg Ala Glu Asn Gly Leu 
            20                  25                  30          


Ser Arg Ala His Ser Ser Ser Glu Glu Thr Ser Ser Val Leu Gln Pro 
        35                  40                  45              


Gly Ile Ala Met Glu Thr Arg Gly Leu Ala Asp Ser Gly Gln Gly Ser 
    50                  55                  60                  


Phe Thr Gly Gln Gly Ile Ala Arg Leu Ser Arg Leu Ile Phe Leu Leu 
65                  70                  75                  80  


Arg Arg Trp Ala Ala Arg His Val His His Gln Asp Gln Gly Pro Asp 
                85                  90                  95      


Ser Phe Pro Asp Arg Phe Arg Gly Ala Glu Leu Lys Glu Val Ser Ser 
            100                 105                 110         


Gln Glu Ser Asn Ala Gln Ala Asn Val Gly Ser Gln Glu Pro Ala Asp 
        115                 120                 125             


Arg Gly Arg Arg Lys Lys Thr Lys Lys Lys Asp Ala Ile Val Val Asp 
    130                 135                 140                 


Pro Ser Ser Asn Leu Tyr Tyr Arg Trp Leu Thr Ala Ile Ala Leu Pro 
145                 150                 155                 160 


Val Phe Tyr Asn Trp Tyr Leu Leu Ile Cys Arg Ala Cys Phe Asp Glu 
                165                 170                 175     


Leu Gln Ser Glu Tyr Leu Met Leu Trp Leu Val Leu Asp Tyr Ser Ala 
            180                 185                 190         


Asp Val Leu Tyr Val Leu Asp Val Leu Val Arg Ala Arg Thr Gly Phe 
        195                 200                 205             


Leu Glu Gln Gly Leu Met Val Ser Asp Thr Asn Arg Leu Trp Gln His 
    210                 215                 220                 


Tyr Lys Thr Thr Thr Gln Phe Lys Leu Asp Val Leu Ser Leu Val Pro 
225                 230                 235                 240 


Thr Asp Leu Ala Tyr Leu Lys Val Gly Thr Asn Tyr Pro Glu Val Arg 
                245                 250                 255     


Phe Asn Arg Leu Leu Lys Phe Ser Arg Leu Phe Glu Phe Phe Asp Arg 
            260                 265                 270         


Thr Glu Thr Arg Thr Asn Tyr Pro Asn Met Phe Arg Ile Gly Asn Leu 
        275                 280                 285             


Val Leu Tyr Ile Leu Ile Ile Ile His Trp Asn Ala Cys Ile Tyr Phe 
    290                 295                 300                 


Ala Ile Ser Lys Phe Ile Gly Phe Gly Thr Asp Ser Trp Val Tyr Pro 
305                 310                 315                 320 


Asn Ile Ser Ile Pro Glu His Gly Arg Leu Ser Arg Lys Tyr Ile Tyr 
                325                 330                 335     


Ser Leu Tyr Trp Ser Thr Leu Thr Leu Thr Thr Ile Gly Glu Thr Pro 
            340                 345                 350         


Pro Pro Val Lys Asp Glu Glu Tyr Leu Phe Val Val Val Asp Phe Leu 
        355                 360                 365             


Val Gly Val Leu Ile Phe Ala Thr Ile Val Gly Asn Val Gly Ser Met 
    370                 375                 380                 


Ile Ser Asn Met Asn Ala Ser Arg Ala Glu Phe Gln Ala Lys Ile Asp 
385                 390                 395                 400 


Ser Ile Lys Gln Tyr Met Gln Phe Arg Lys Val Thr Lys Asp Leu Glu 
                405                 410                 415     


Thr Arg Val Ile Arg Trp Phe Asp Tyr Leu Trp Ala Asn Lys Lys Thr 
            420                 425                 430         


Val Asp Glu Lys Glu Val Leu Lys Ser Leu Pro Asp Lys Leu Lys Ala 
        435                 440                 445             


Glu Ile Ala Ile Asn Val His Leu Asp Thr Leu Lys Lys Val Arg Ile 
    450                 455                 460                 


Phe Gln Asp Cys Glu Ala Gly Leu Leu Val Glu Leu Val Leu Lys Leu 
465                 470                 475                 480 


Arg Pro Thr Val Phe Ser Pro Gly Asp Tyr Ile Cys Lys Lys Gly Asp 
                485                 490                 495     


Ile Gly Lys Glu Met Tyr Ile Ile Asn Glu Gly Lys Leu Ala Val Val 
            500                 505                 510         


Ala Asp Asp Gly Val Thr Gln Phe Val Val Leu Ser Asp Gly Ser Tyr 
        515                 520                 525             


Phe Gly Glu Ile Ser Ile Leu Asn Ile Lys Gly Ser Lys Ser Gly Asn 
    530                 535                 540                 


Arg Arg Thr Ala Asn Ile Arg Ser Ile Gly Tyr Ser Asp Leu Phe Cys 
545                 550                 555                 560 


Leu Ser Lys Asp Asp Leu Met Glu Ala Leu Thr Glu Tyr Pro Glu Ala 
                565                 570                 575     


Lys Lys Ala Leu Glu Glu Lys Gly Arg Gln Ile Leu Met Lys Asp Asn 
            580                 585                 590         


Leu Ile Asp Glu Glu Leu Ala Arg Ala Gly Ala Asp Pro Lys Asp Leu 
        595                 600                 605             


Glu Glu Lys Val Glu Gln Leu Gly Ser Ser Leu Asp Thr Leu Gln Thr 
    610                 615                 620                 


Arg Phe Ala Arg Leu Leu Ala Glu Tyr Asn Ala Thr Gln Met Lys Met 
625                 630                 635                 640 


Lys Gln Arg Leu Ser Gln Leu Glu Ser Gln Val Lys Gly Gly Gly Asp 
                645                 650                 655     


Lys Pro Leu Ala Asp Gly Glu Val Pro Gly Asp Ala Thr Lys Thr Glu 
            660                 665                 670         


Asp Lys Gln Gln 
        675     


<210>  1011
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  1011

Met Ala Asn Leu Gly Cys Trp Met Leu Val Leu Phe Val Ala Thr Trp 
1               5                   10                  15      


Ser Asp Leu Gly Leu Cys Lys Lys Arg Pro Lys Pro Gly Gly Trp Asn 
            20                  25                  30          


Thr Gly Gly Ser Arg Tyr Pro Gly Gln Gly Ser Pro Gly Gly Asn Arg 
        35                  40                  45              


Tyr Pro Pro Gln Gly Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly 
    50                  55                  60                  


Trp Gly Gln Pro His Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly 
65                  70                  75                  80  


Trp Gly Gln Pro His Gly Gly Gly Trp Gly Gln Gly Gly Gly Thr His 
                85                  90                  95      


Ser Gln Trp Asn Lys Pro Ser Lys Pro Lys Thr Asn Met Lys His Met 
            100                 105                 110         


Ala Gly Ala Ala Ala Ala Gly Ala Val Val Gly Gly Leu Gly Gly Tyr 
        115                 120                 125             


Met Leu Gly Ser Ala Met Ser Arg Pro Ile Ile His Phe Gly Ser Asp 
    130                 135                 140                 


Tyr Glu Asp Arg Tyr Tyr Arg Glu Asn Met His Arg Tyr Pro Asn Gln 
145                 150                 155                 160 


Val Tyr Tyr Arg Pro Met Asp Glu Tyr Ser Asn Gln Asn Asn Phe Val 
                165                 170                 175     


His Asp Cys Val Asn Ile Thr Ile Lys Gln His Thr Val Thr Thr Thr 
            180                 185                 190         


Thr Lys Gly Glu Asn Phe Thr Glu Thr Asp Val Lys Met Met Glu Arg 
        195                 200                 205             


Val Val Glu Gln Met Cys Ile Thr Gln Tyr Glu Arg Glu Ser Gln Ala 
    210                 215                 220                 


Tyr Tyr Gln Arg Gly Ser Ser Met Val Leu Phe Ser Ser Pro Pro Val 
225                 230                 235                 240 


Ile Leu Leu Ile Ser Phe Leu Ile Phe Leu Ile Val Gly 
                245                 250             


<210>  1012
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  1012

Met Ala Asn Leu Gly Cys Trp Met Leu Val Leu Phe Val Ala Thr Trp 
1               5                   10                  15      


Ser Asp Leu Gly Leu Cys Lys Lys Arg Pro Lys Pro Gly Gly Trp Asn 
            20                  25                  30          


Thr Gly Gly Ser Arg Tyr Pro Gly Gln Gly Ser Pro Gly Gly Asn Arg 
        35                  40                  45              


Tyr Pro Pro Gln Gly Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly 
    50                  55                  60                  


Trp Gly Gln Pro His Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly 
65                  70                  75                  80  


Trp Gly Gln Pro His Gly Gly Gly Trp Gly Gln Gly Gly Gly Thr His 
                85                  90                  95      


Ser Gln Trp Asn Lys Pro Ser Lys Pro Lys Thr Asn Met Lys His Met 
            100                 105                 110         


Ala Gly Ala Ala Ala Ala Gly Ala Val Val Gly Gly Leu Gly Gly Tyr 
        115                 120                 125             


Met Leu Gly Ser Ala Met Ser Arg Pro Ile Ile His Phe Gly Ser Asp 
    130                 135                 140                 


Tyr Glu Asp Arg Tyr Tyr Arg Glu Asn Met His Arg Tyr Pro Asn Gln 
145                 150                 155                 160 


Val Tyr Tyr Arg Pro Met Asp Glu Tyr Ser Asn Gln Asn Asn Phe Val 
                165                 170                 175     


His Asp Cys Val Asn Ile Thr Ile Lys Gln His Thr Val Thr Thr Thr 
            180                 185                 190         


Thr Lys Gly Glu Asn Phe Thr Glu Thr Asp Val Lys Met Met Glu Arg 
        195                 200                 205             


Val Val Glu Gln Met Cys Ile Thr Gln Tyr Glu Arg Glu Ser Gln Ala 
    210                 215                 220                 


Tyr Tyr Gln Arg Gly Ser Ser Met Val Leu Phe Ser Ser Pro Pro Val 
225                 230                 235                 240 


Ile Leu Leu Ile Ser Phe Leu Ile Phe Leu Ile Val Gly 
                245                 250             


<210>  1013
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  1013

Met Ala Asn Leu Gly Cys Trp Met Leu Val Leu Phe Val Ala Thr Trp 
1               5                   10                  15      


Ser Asp Leu Gly Leu Cys Lys Lys Arg Pro Lys Pro Gly Gly Trp Asn 
            20                  25                  30          


Thr Gly Gly Ser Arg Tyr Pro Gly Gln Gly Ser Pro Gly Gly Asn Arg 
        35                  40                  45              


Tyr Pro Pro Gln Gly Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly 
    50                  55                  60                  


Trp Gly Gln Pro His Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly 
65                  70                  75                  80  


Trp Gly Gln Pro His Gly Gly Gly Trp Gly Gln Gly Gly Gly Thr His 
                85                  90                  95      


Ser Gln Trp Asn Lys Pro Ser Lys Pro Lys Thr Asn Met Lys His Met 
            100                 105                 110         


Ala Gly Ala Ala Ala Ala Gly Ala Val Val Gly Gly Leu Gly Gly Tyr 
        115                 120                 125             


Met Leu Gly Ser Ala Met Ser Arg Pro Ile Ile His Phe Gly Ser Asp 
    130                 135                 140                 


Tyr Glu Asp Arg Tyr Tyr Arg Glu Asn Met His Arg Tyr Pro Asn Gln 
145                 150                 155                 160 


Val Tyr Tyr Arg Pro Met Asp Glu Tyr Ser Asn Gln Asn Asn Phe Val 
                165                 170                 175     


His Asp Cys Val Asn Ile Thr Ile Lys Gln His Thr Val Thr Thr Thr 
            180                 185                 190         


Thr Lys Gly Glu Asn Phe Thr Glu Thr Asp Val Lys Met Met Glu Arg 
        195                 200                 205             


Val Val Glu Gln Met Cys Ile Thr Gln Tyr Glu Arg Glu Ser Gln Ala 
    210                 215                 220                 


Tyr Tyr Gln Arg Gly Ser Ser Met Val Leu Phe Ser Ser Pro Pro Val 
225                 230                 235                 240 


Ile Leu Leu Ile Ser Phe Leu Ile Phe Leu Ile Val Gly 
                245                 250             


<210>  1014
<211>  621
<212>  PRT
<213>  Homo sapiens

<400>  1014

Met Ile Ala Thr Gly Gly Leu Leu Arg Ile Ser Ala Arg Lys Gln Asp 
1               5                   10                  15      


Pro Leu Arg Pro Pro Ser Gln Ile Pro Lys Arg Lys Arg Lys Ala Lys 
            20                  25                  30          


Lys Arg Arg Lys Asn Asp Val Val Val Val Lys Gly Lys Leu Lys Leu 
        35                  40                  45              


Cys Ser Ile Ser Gly Leu Ile Ala Leu Cys Gly Ile Leu Val Leu Leu 
    50                  55                  60                  


Val Gly Ile Ala Met Ala Val Val Gly Tyr Trp Pro Lys Ala Thr Gly 
65                  70                  75                  80  


Thr Asn Arg Glu Gly Gly Lys Gln Leu Pro Pro Ala Gly Ser Ser His 
                85                  90                  95      


Arg Val Pro Thr Thr Ala Asn Ser Ser Ser Ser Gly Ser Lys Asn Arg 
            100                 105                 110         


Ser Arg Ser His Pro Arg Ala Pro Gly Gly Val Asn Ser Ser Ser Ala 
        115                 120                 125             


Gly Ala Pro Arg Ser Thr Pro Pro Ala Arg Ala Ala Ser Pro Ser Ser 
    130                 135                 140                 


Ser Ser Thr Ser Val Gly Phe Phe Phe Arg Ile Phe Ser Gly Tyr Leu 
145                 150                 155                 160 


His Ser Asp Lys Leu Lys Val Phe Gly Pro Leu Ile Met Gly Ile Gly 
                165                 170                 175     


Ile Phe Leu Phe Ile Cys Ala Asn Ala Val Leu His Glu Asn Arg Asp 
            180                 185                 190         


Lys Lys Thr Lys Ile Ile Asn Leu Arg Asp Leu Tyr Ser Thr Val Ile 
        195                 200                 205             


Asp Val His Ser Leu Arg Ala Lys Asp Leu Ala Ala Ala Ala Ala Ala 
    210                 215                 220                 


Ala Ala Ala Ala Ala Ala Ser Ser Ser Ser Ser Ala Pro Ala Ala Ala 
225                 230                 235                 240 


Pro Pro Gly Ala Ile Pro Leu Asn Gly Phe Leu Ser Tyr Val Gln Ser 
                245                 250                 255     


Arg Gly Leu Glu Leu Lys Pro Gly Gly Cys Gly Gly Ser Gly Asp Ala 
            260                 265                 270         


Phe Gly Ala Ala Ala Met Leu Ala Lys Gly Ser Trp Pro Pro His Pro 
        275                 280                 285             


Ala Ala Pro Ser Gly Gly Arg Pro Arg Gly Ala Ala Ser Pro Pro Asp 
    290                 295                 300                 


Leu Ala Ser Ser Pro Arg Cys Pro Arg Glu Pro Pro Ser Leu Ala Glu 
305                 310                 315                 320 


Ala Val Tyr Ser Val Tyr Arg Glu Arg Ser Gly Val Ala Gly Ser Arg 
                325                 330                 335     


Arg Ala Ala Ala Ala Thr Ala Ala Ala Ala Ala Ser Ser Cys Ser Ser 
            340                 345                 350         


Pro Ala Pro Cys Ser Pro Pro Glu Ser Trp Gly Arg Gln Ser Thr Ala 
        355                 360                 365             


Ser Ser Phe Val Asp Ser Ser Leu Ser Ala Phe Ala Leu Leu Pro Leu 
    370                 375                 380                 


Gln Gly Gly Arg Asp Arg Gly Gly Asp Ala Glu Gly Ala Ser Cys Ser 
385                 390                 395                 400 


Trp Gln Arg Pro Pro Gly Glu Arg Gly Ser Gln Glu Ile Pro Arg Gly 
                405                 410                 415     


Glu Leu Asp Leu Ser Met Thr Asn Leu Arg Gly Ala Glu Gly Ser Met 
            420                 425                 430         


Arg Gly Ala Arg Arg Glu Pro Glu Glu Pro Glu Gly Ala Val Ala Ala 
        435                 440                 445             


Arg Ala Ala Arg Gly Gln Gly Gly Arg Leu Pro Arg Thr Gly Arg Tyr 
    450                 455                 460                 


Ala Ala Leu Arg Arg Arg Ser Thr Ser Gly Leu Pro Asp Tyr Arg Ala 
465                 470                 475                 480 


Pro Pro Ser Pro Glu Pro Pro Pro Ser Pro Gly Ser Ala Asp Pro Asp 
                485                 490                 495     


Ser Ser Pro Leu Ala Lys Ala Ala Ser Pro Ser Pro Pro Leu Arg Leu 
            500                 505                 510         


Glu Gly Ser Pro Pro Thr Arg Arg Asp Ser Gly Ser Ser Gln Ser Asp 
        515                 520                 525             


Asp Pro Ser Ser Ser Asn Lys Gly Tyr Thr Pro Leu Arg Glu Ala Gly 
    530                 535                 540                 


Thr Ser Thr Glu Ser Val Leu Asp Ala Val Ala Gly Gln Thr Arg Asp 
545                 550                 555                 560 


Ser Ala Val Ala Ala Pro Val Leu Gly Ala Glu Gln Ser Ser Pro Glu 
                565                 570                 575     


Gly Ala Ser Gln Glu Pro Pro Thr Ala Glu Gln Pro Gln Pro Val Gln 
            580                 585                 590         


Arg Gln Phe Thr Asn Lys Glu Lys Leu Ile Met Ile Ser Arg Ser His 
        595                 600                 605             


Ala Ile Gly Val Glu Glu Glu Leu Glu Ser Thr Gly Ile 
    610                 615                 620     


<210>  1015
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  1015

Met Val Ala Glu Lys Glu Thr Leu Ser Leu Asn Lys Cys Pro Asp Lys 
1               5                   10                  15      


Met Pro Lys Arg Thr Lys Leu Leu Ala Gln Gln Pro Leu Pro Val His 
            20                  25                  30          


Gln Pro His Ser Leu Val Ser Glu Gly Phe Thr Val Lys Ala Met Met 
        35                  40                  45              


Lys Asn Ser Val Val Arg Gly Pro Pro Ala Ala Gly Ala Phe Lys Glu 
    50                  55                  60                  


Arg Pro Thr Lys Pro Thr Ala Phe Arg Lys Phe Tyr Glu Arg Gly Asp 
65                  70                  75                  80  


Phe Pro Ile Ala Leu Glu His Asp Ser Lys Gly Asn Lys Ile Ala Trp 
                85                  90                  95      


Lys Val Glu Ile Glu Lys Leu Asp Tyr His His Tyr Leu Pro Leu Phe 
            100                 105                 110         


Phe Asp Gly Leu Cys Glu Met Thr Phe Pro Tyr Glu Phe Phe Ala Arg 
        115                 120                 125             


Gln Gly Ile His Asp Met Leu Glu His Gly Gly Asn Lys Ile Leu Pro 
    130                 135                 140                 


Val Leu Pro Gln Leu Ile Ile Pro Ile Lys Asn Ala Leu Asn Leu Arg 
145                 150                 155                 160 


Asn Arg Gln Val Ile Cys Val Thr Leu Lys Val Leu Gln His Leu Val 
                165                 170                 175     


Val Ser Ala Glu Met Val Gly Lys Ala Leu Val Pro Tyr Tyr Arg Gln 
            180                 185                 190         


Ile Leu Pro Val Leu Asn Ile Phe Lys Asn Met Asn Val Asn Ser Gly 
        195                 200                 205             


Asp Gly Ile Asp Tyr Ser Gln Gln Lys Arg Glu Asn Ile Gly Asp Leu 
    210                 215                 220                 


Ile Gln Glu Thr Leu Glu Ala Phe Glu Arg Tyr Gly Gly Glu Asn Ala 
225                 230                 235                 240 


Phe Ile Asn Ile Lys Tyr Val Val Pro Thr Tyr Glu Ser Cys Leu Leu 
                245                 250                 255     


Asn 
    


<210>  1016
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  1016

Met Val Ala Glu Lys Glu Thr Leu Ser Leu Asn Lys Cys Pro Asp Lys 
1               5                   10                  15      


Met Pro Lys Arg Thr Lys Leu Leu Ala Gln Gln Pro Leu Pro Val His 
            20                  25                  30          


Gln Pro His Ser Leu Val Ser Glu Gly Phe Thr Val Lys Ala Met Met 
        35                  40                  45              


Lys Asn Ser Val Val Arg Gly Pro Pro Ala Ala Gly Ala Phe Lys Glu 
    50                  55                  60                  


Arg Pro Thr Lys Pro Thr Ala Phe Arg Lys Phe Tyr Glu Arg Gly Asp 
65                  70                  75                  80  


Phe Pro Ile Ala Leu Glu His Asp Ser Lys Gly Asn Lys Ile Ala Trp 
                85                  90                  95      


Lys Val Glu Ile Glu Lys Leu Asp Tyr His His Tyr Leu Pro Leu Phe 
            100                 105                 110         


Phe Asp Gly Leu Cys Glu Met Thr Phe Pro Tyr Glu Phe Phe Ala Arg 
        115                 120                 125             


Gln Gly Ile His Asp Met Leu Glu His Gly Gly Asn Lys Ile Leu Pro 
    130                 135                 140                 


Val Leu Pro Gln Leu Ile Ile Pro Ile Lys Asn Ala Leu Asn Leu Arg 
145                 150                 155                 160 


Asn Arg Gln Val Ile Cys Val Thr Leu Lys Val Leu Gln His Leu Val 
                165                 170                 175     


Val Ser Ala Glu Met Val Gly Lys Ala Leu Val Pro Tyr Tyr Arg Gln 
            180                 185                 190         


Ile Leu Pro Val Leu Asn Ile Phe Lys Asn Met Asn Val Asn Ser Gly 
        195                 200                 205             


Asp Gly Ile Asp Tyr Ser Gln Gln Lys Arg Glu Asn Ile Gly Asp Leu 
    210                 215                 220                 


Ile Gln Glu Thr Leu Glu Ala Phe Glu Arg Tyr Gly Gly Glu Asn Ala 
225                 230                 235                 240 


Phe Ile Asn Ile Lys Tyr Val Val Pro Thr Tyr Glu Ser Cys Leu Leu 
                245                 250                 255     


Asn 
    


<210>  1017
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  1017

Met Ser Trp Ser Phe Leu Thr Arg Leu Leu Glu Glu Ile His Asn His 
1               5                   10                  15      


Ser Thr Phe Val Gly Lys Ile Trp Leu Thr Val Leu Ile Val Phe Arg 
            20                  25                  30          


Ile Val Leu Thr Ala Val Gly Gly Glu Ser Ile Tyr Tyr Asp Glu Gln 
        35                  40                  45              


Ser Lys Phe Val Cys Asn Thr Glu Gln Pro Gly Cys Glu Asn Val Cys 
    50                  55                  60                  


Tyr Asp Ala Phe Ala Pro Leu Ser His Val Arg Phe Trp Val Phe Gln 
65                  70                  75                  80  


Ile Ile Leu Val Ala Thr Pro Ser Val Met Tyr Leu Gly Tyr Ala Ile 
                85                  90                  95      


His Lys Ile Ala Lys Met Glu His Gly Glu Ala Asp Lys Lys Ala Ala 
            100                 105                 110         


Arg Ser Lys Pro Tyr Ala Met Arg Trp Lys Gln His Arg Ala Leu Glu 
        115                 120                 125             


Glu Thr Glu Glu Asp Asn Glu Glu Asp Pro Met Met Tyr Pro Glu Met 
    130                 135                 140                 


Glu Leu Glu Ser Asp Lys Glu Asn Lys Glu Gln Ser Gln Pro Lys Pro 
145                 150                 155                 160 


Lys His Asp Gly Arg Arg Arg Ile Arg Glu Asp Gly Leu Met Lys Ile 
                165                 170                 175     


Tyr Val Leu Gln Leu Leu Ala Arg Thr Val Phe Glu Val Gly Phe Leu 
            180                 185                 190         


Ile Gly Gln Tyr Phe Leu Tyr Gly Phe Gln Val His Pro Phe Tyr Val 
        195                 200                 205             


Cys Ser Arg Leu Pro Cys Pro His Lys Ile Asp Cys Phe Ile Ser Arg 
    210                 215                 220                 


Pro Thr Glu Lys Thr Ile Phe Leu Leu Ile Met Tyr Gly Val Thr Gly 
225                 230                 235                 240 


Leu Cys Leu Leu Leu Asn Ile Trp Glu Met Leu His Leu Gly Phe Gly 
                245                 250                 255     


Thr Ile Arg Asp Ser Leu Asn Ser Lys Arg Arg Glu Leu Glu Asp Pro 
            260                 265                 270         


Gly Ala Tyr Asn Tyr Pro Phe Thr Trp Asn Thr Pro Ser Ala Pro Pro 
        275                 280                 285             


Gly Tyr Asn Ile Ala Val Lys Pro Asp Gln Ile Gln Tyr Thr Glu Leu 
    290                 295                 300                 


Ser Asn Ala Lys Ile Ala Tyr Lys Gln Asn Lys Ala Asn Thr Ala Gln 
305                 310                 315                 320 


Glu Gln Gln Tyr Gly Ser His Glu Glu Asn Leu Pro Ala Asp Leu Glu 
                325                 330                 335     


Ala Leu Gln Arg Glu Ile Arg Met Ala Gln Glu Arg Leu Asp Leu Ala 
            340                 345                 350         


Val Gln Ala Tyr Ser His Gln Asn Asn Pro His Gly Pro Arg Glu Lys 
        355                 360                 365             


Lys Ala Lys Val Gly Ser Lys Ala Gly Ser Asn Lys Ser Thr Ala Ser 
    370                 375                 380                 


Ser Lys Ser Gly Asp Gly Lys Thr Ser Val Trp Ile 
385                 390                 395     


<210>  1018
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  1018

Met Lys Leu Arg Ser Lys Ala Ala Ala Leu Leu Leu Leu Ala Leu Ala 
1               5                   10                  15      


Ala Leu Leu Leu Ala Leu Leu Ser Leu Arg Ala Gly Arg Ala Glu Pro 
            20                  25                  30          


Pro Ala Leu Pro Ala Arg Pro Ala Ser Ala Pro Gln Arg His Pro Ala 
        35                  40                  45              


Pro Val Pro Ala Arg Trp Pro Gly Pro Gly Ala Leu Pro Gly Ala Ser 
    50                  55                  60                  


Pro Gly Val Arg Arg Arg Arg Pro Pro Arg Pro Arg Pro Arg Ala Gly 
65                  70                  75                  80  


Arg Arg Gly Ala Ala Arg Leu Glu Lys Leu Ala Arg Arg Pro Gly Glu 
                85                  90                  95      


Pro Arg Ser Phe Gln Ala Val Leu Pro Pro Glu Leu Trp Ile His Leu 
            100                 105                 110         


Ala Val Val Ala Cys Gly Asn Arg Leu Glu Glu Thr Leu Val Met Leu 
        115                 120                 125             


Lys Ser Ala Val Leu Phe Ser His Arg Lys Ile Gln Phe His Ile Phe 
    130                 135                 140                 


Thr Glu Asp Ser Leu Lys Pro Glu Phe Asp Lys Gln Leu Arg Gln Trp 
145                 150                 155                 160 


Pro Asp Ser Tyr Thr Lys Lys Phe Glu His Arg Ile Tyr Pro Ile Thr 
                165                 170                 175     


Phe Ser Val Gly Asn Pro Gln Glu Trp Lys Lys Leu Phe Lys Pro Cys 
            180                 185                 190         


Ala Ala Gln Arg Leu Phe Leu Pro Val Ile Leu Lys Asp Val Asp Ser 
        195                 200                 205             


Leu Leu Tyr Val Asp Thr Asp Val Leu Phe Leu Arg Pro Val Asp Asp 
    210                 215                 220                 


Ile Trp Lys Leu Leu Arg Leu Phe Asn Ser Thr Gln Leu Ala Ala Met 
225                 230                 235                 240 


Ala Pro Glu His Glu Ile Pro Lys Ile Gly Trp Tyr Ser Arg Phe Ala 
                245                 250                 255     


Arg His Pro Phe Tyr Gly Ser Ala Gly Val Asn Ser Gly Val Met Leu 
            260                 265                 270         


Met Asn Leu Thr Arg Ile Arg Ser Thr Gln Phe Lys Asn Ser Met Ile 
        275                 280                 285             


Pro Thr Gly Leu Ala Trp Glu Asp Met Leu Tyr Pro Leu Tyr Gln Lys 
    290                 295                 300                 


Tyr Lys Asn Ala Ile Thr Trp Gly Asp Gln Asp Leu Leu Asn Ile Ile 
305                 310                 315                 320 


Phe Tyr Phe Asn Pro Glu Cys Leu Tyr Val Phe Pro Cys Gln Trp Asn 
                325                 330                 335     


Tyr Arg Pro Asp His Cys Met Tyr Gly Ser Asn Cys Arg Glu Ala Glu 
            340                 345                 350         


His Glu Gly Val Ser Val Leu His Gly Asn Arg Gly Val Tyr His Asp 
        355                 360                 365             


Asp Lys Gln Pro Thr Phe Arg Ala Leu Tyr Glu Ala Ile Arg Asp Phe 
    370                 375                 380                 


Pro Phe Gln Asp Asn Leu Phe Gln Ser Met Tyr Tyr Pro Leu Gln Leu 
385                 390                 395                 400 


Lys Phe Leu Glu Thr Val His Thr Leu Cys Gly Arg Ile Pro Gln Val 
                405                 410                 415     


Phe Leu Lys Gln Ile Glu Lys Thr Met Lys Arg Ala Tyr Glu Lys His 
            420                 425                 430         


Val Ile Ile His Val Gly Pro Asn Gln Met His 
        435                 440             


<210>  1019
<211>  782
<212>  PRT
<213>  Homo sapiens

<400>  1019

Met Leu Gln Gln Pro Gly Pro Arg Pro Gly Arg Gln Gln Pro Ser Gly 
1               5                   10                  15      


Asp Arg Asp Ala Cys Arg Leu His Pro Gln Gly Arg Pro Pro Ala Leu 
            20                  25                  30          


Pro Thr Met Ile Pro Ala Ala Ser Ser Thr Pro Pro Gly Asp Ala Leu 
        35                  40                  45              


Phe Pro Ser Val Ala Pro Gln Asp Phe Trp Arg Ser Gln Val Thr Gly 
    50                  55                  60                  


Tyr Ser Gly Ser Val Thr Arg His Leu Ser His Arg Ala Asn Asn Phe 
65                  70                  75                  80  


Lys Arg His Pro Lys Arg Arg Lys Cys Ile Arg Pro Ser Pro Pro Pro 
                85                  90                  95      


Pro Pro Asn Thr Pro Cys Pro Leu Glu Leu Val Asp Phe Gly Asp Leu 
            100                 105                 110         


His Pro Gln Arg Ser Phe Arg Glu Leu Leu Phe Asn Gly Cys Ile Leu 
        115                 120                 125             


Phe Gly Ile Glu Phe Ser Tyr Ala Met Glu Thr Ala Tyr Val Thr Pro 
    130                 135                 140                 


Val Leu Leu Gln Met Gly Leu Pro Asp Gln Leu Tyr Ser Leu Val Trp 
145                 150                 155                 160 


Phe Ile Ser Pro Ile Leu Gly Phe Leu Leu Gln Pro Leu Leu Gly Ala 
                165                 170                 175     


Trp Ser Asp Arg Cys Thr Ser Arg Phe Gly Arg Arg Arg Pro Phe Ile 
            180                 185                 190         


Leu Val Leu Ala Ile Gly Ala Leu Leu Gly Leu Ser Leu Leu Leu Asn 
        195                 200                 205             


Gly Arg Asp Ile Gly Ile Ala Leu Ala Asp Val Thr Gly Asn His Lys 
    210                 215                 220                 


Trp Gly Leu Leu Leu Thr Val Cys Gly Val Val Leu Met Asp Phe Ser 
225                 230                 235                 240 


Ala Asp Ser Ala Asp Asn Pro Ser His Ala Tyr Met Met Asp Val Cys 
                245                 250                 255     


Ser Pro Ala Asp Gln Asp Arg Gly Leu Asn Ile His Ala Leu Leu Ala 
            260                 265                 270         


Gly Leu Gly Gly Gly Phe Gly Tyr Val Val Gly Gly Ile His Trp Asp 
        275                 280                 285             


Lys Thr Gly Phe Gly Arg Ala Leu Gly Gly Gln Leu Arg Val Ile Tyr 
    290                 295                 300                 


Leu Phe Thr Ala Val Thr Leu Ser Val Thr Thr Val Leu Thr Leu Val 
305                 310                 315                 320 


Ser Ile Pro Glu Arg Pro Leu Arg Pro Pro Ser Glu Lys Arg Ala Ala 
                325                 330                 335     


Met Lys Ser Pro Ser Leu Pro Leu Pro Pro Ser Pro Pro Val Leu Pro 
            340                 345                 350         


Glu Glu Gly Pro Gly Asp Ser Leu Pro Ser His Thr Ala Thr Asn Phe 
        355                 360                 365             


Ser Ser Pro Ile Ser Pro Pro Ser Pro Leu Thr Pro Lys Tyr Gly Ser 
    370                 375                 380                 


Phe Ile Ser Arg Asp Ser Ser Leu Thr Gly Ile Ser Glu Phe Ala Ser 
385                 390                 395                 400 


Ser Phe Gly Thr Ala Asn Ile Asp Ser Val Leu Ile Asp Cys Phe Thr 
                405                 410                 415     


Gly Gly His Asp Ser Tyr Leu Ala Ile Pro Gly Ser Val Pro Arg Pro 
            420                 425                 430         


Pro Ile Ser Val Ser Phe Pro Arg Ala Pro Asp Gly Phe Tyr Arg Gln 
        435                 440                 445             


Asp Arg Gly Leu Leu Glu Gly Arg Glu Gly Ala Leu Thr Ser Gly Cys 
    450                 455                 460                 


Asp Gly Asp Ile Leu Arg Val Gly Ser Leu Asp Thr Ser Lys Pro Arg 
465                 470                 475                 480 


Ser Ser Gly Ile Leu Lys Arg Pro Gln Thr Leu Ala Ile Pro Asp Ala 
                485                 490                 495     


Ala Gly Gly Gly Gly Pro Glu Thr Ser Arg Arg Arg Asn Val Thr Phe 
            500                 505                 510         


Ser Gln Gln Val Ala Asn Ile Leu Leu Asn Gly Val Lys Tyr Glu Ser 
        515                 520                 525             


Glu Leu Thr Gly Ser Ser Glu Arg Ala Glu Gln Pro Leu Ser Val Gly 
    530                 535                 540                 


Arg Leu Cys Ser Thr Ile Cys Asn Met Pro Lys Ala Leu Arg Thr Leu 
545                 550                 555                 560 


Cys Val Asn His Phe Leu Gly Trp Leu Ser Phe Glu Gly Met Leu Leu 
                565                 570                 575     


Phe Tyr Thr Asp Phe Met Gly Glu Val Val Phe Gln Gly Asp Pro Lys 
            580                 585                 590         


Ala Pro His Thr Ser Glu Ala Tyr Gln Lys Tyr Asn Ser Gly Val Thr 
        595                 600                 605             


Met Gly Cys Trp Gly Met Cys Ile Tyr Ala Phe Ser Ala Ala Phe Tyr 
    610                 615                 620                 


Ser Ala Ile Leu Glu Lys Leu Glu Glu Phe Leu Ser Val Arg Thr Leu 
625                 630                 635                 640 


Tyr Phe Ile Ala Tyr Leu Ala Phe Gly Leu Gly Thr Gly Leu Ala Thr 
                645                 650                 655     


Leu Ser Arg Asn Leu Tyr Val Val Leu Ser Leu Cys Ile Thr Tyr Gly 
            660                 665                 670         


Ile Leu Phe Ser Thr Leu Cys Thr Leu Pro Tyr Ser Leu Leu Cys Asp 
        675                 680                 685             


Tyr Tyr Gln Ser Lys Lys Phe Ala Gly Ser Ser Ala Asp Gly Thr Arg 
    690                 695                 700                 


Arg Gly Met Gly Val Asp Ile Ser Leu Leu Ser Cys Gln Tyr Phe Leu 
705                 710                 715                 720 


Ala Gln Ile Leu Val Ser Leu Val Leu Gly Pro Leu Thr Ser Ala Val 
                725                 730                 735     


Gly Ser Ala Asn Gly Val Met Tyr Phe Ser Ser Leu Val Ser Phe Leu 
            740                 745                 750         


Gly Cys Leu Tyr Ser Ser Leu Phe Val Ile Tyr Glu Ile Pro Pro Ser 
        755                 760                 765             


Asp Ala Ala Asp Glu Glu His Arg Pro Leu Leu Leu Asn Val 
    770                 775                 780         


<210>  1020
<211>  1606
<212>  PRT
<213>  Homo sapiens

<400>  1020

Met Phe Pro Lys Ser Asn Leu Thr Val Thr Cys Trp Val Trp Arg Ser 
1               5                   10                  15      


Met Arg Lys Leu Phe Leu Leu Leu Ser Leu Leu Leu Ser His Ala Ala 
            20                  25                  30          


His Leu Glu Gly Lys Lys Asp Asn Gln Phe Ile Trp Lys Pro Gly Pro 
        35                  40                  45              


Trp Gly Arg Cys Thr Gly Asp Cys Gly Pro Gly Gly Val Gln Ser Arg 
    50                  55                  60                  


Ala Val Trp Cys Phe His Val Asp Gly Trp Thr Ser His Leu Ser Asn 
65                  70                  75                  80  


Cys Gly Glu Ser Asn Arg Pro Pro Lys Glu Arg Ser Cys Phe Arg Val 
                85                  90                  95      


Cys Asp Trp His Ser Asp Leu Phe Gln Trp Glu Val Ser Asp Trp His 
            100                 105                 110         


His Cys Val Leu Val Pro Tyr Ala Arg Gly Glu Val Lys Pro Arg Thr 
        115                 120                 125             


Ala Glu Cys Val Thr Ala Gln His Gly Leu Gln His Arg Met Val Arg 
    130                 135                 140                 


Cys Ile Gln Lys Leu Asn Arg Thr Val Val Ala Asn Glu Ile Cys Glu 
145                 150                 155                 160 


His Phe Ala Leu Gln Pro Pro Thr Glu Gln Ala Cys Leu Ile Pro Cys 
                165                 170                 175     


Pro Arg Asp Cys Val Val Ser Glu Phe Leu Pro Trp Ser Asn Cys Ser 
            180                 185                 190         


Lys Gly Cys Gly Lys Lys Leu Gln His Arg Thr Arg Ala Val Ile Ala 
        195                 200                 205             


Pro Pro Leu Phe Gly Gly Leu Gln Cys Pro Asn Leu Thr Glu Ser Arg 
    210                 215                 220                 


Ala Cys Asp Ala Pro Ile Ser Cys Pro Leu Gly Glu Glu Glu Tyr Thr 
225                 230                 235                 240 


Phe Ser Leu Lys Val Gly Pro Trp Ser Lys Cys Arg Leu Pro His Leu 
                245                 250                 255     


Lys Glu Ile Asn Pro Ser Gly Arg Thr Val Leu Asp Phe Asn Ser Asp 
            260                 265                 270         


Ser Asn Glu Arg Val Thr Phe Lys His Gln Ser Tyr Lys Ala His His 
        275                 280                 285             


His Ser Lys Ser Trp Ala Ile Glu Ile Gly Tyr Gln Thr Arg Gln Val 
    290                 295                 300                 


Ser Cys Thr Arg Ser Asp Gly Gln Asn Ala Met Leu Ser Leu Cys Leu 
305                 310                 315                 320 


Gln Asp Ser Phe Pro Leu Thr Val Gln Ser Cys Ile Met Pro Lys Asp 
                325                 330                 335     


Cys Glu Thr Ser Gln Trp Ser Ser Trp Ser Pro Cys Ser Lys Thr Cys 
            340                 345                 350         


Arg Ser Gly Ser Leu Leu Pro Gly Phe Arg Ser Arg Ser Arg Asn Val 
        355                 360                 365             


Lys His Met Ala Ile Gly Gly Gly Lys Glu Cys Pro Glu Leu Leu Glu 
    370                 375                 380                 


Lys Glu Ala Cys Ile Val Glu Gly Glu Leu Leu Gln Gln Cys Pro Arg 
385                 390                 395                 400 


Tyr Ser Trp Arg Thr Ser Glu Trp Lys Glu Cys Gln Val Ser Leu Leu 
                405                 410                 415     


Leu Glu Gln Gln Asp Pro His Trp His Val Thr Gly Pro Val Cys Gly 
            420                 425                 430         


Gly Gly Ile Gln Thr Arg Glu Val Tyr Cys Ala Gln Ser Val Pro Ala 
        435                 440                 445             


Ala Ala Ala Leu Arg Ala Lys Glu Val Ser Arg Pro Val Glu Lys Ala 
    450                 455                 460                 


Leu Cys Val Gly Pro Ala Pro Leu Pro Ser Gln Leu Cys Asn Ile Pro 
465                 470                 475                 480 


Cys Ser Thr Asp Cys Ile Val Ser Ser Trp Ser Ala Trp Gly Leu Cys 
                485                 490                 495     


Ile His Glu Asn Cys His Asp Pro Gln Gly Lys Lys Gly Phe Arg Thr 
            500                 505                 510         


Arg Gln Arg His Val Leu Met Glu Ser Thr Gly Pro Ala Gly His Cys 
        515                 520                 525             


Pro His Leu Val Glu Ser Val Pro Cys Glu Asp Pro Met Cys Tyr Arg 
    530                 535                 540                 


Trp Leu Ala Ser Glu Gly Ile Cys Phe Pro Asp His Gly Lys Cys Gly 
545                 550                 555                 560 


Leu Gly His Arg Ile Leu Lys Ala Val Cys Gln Asn Asp Arg Gly Glu 
                565                 570                 575     


Asp Val Ser Gly Ser Leu Cys Pro Val Pro Pro Pro Pro Glu Arg Lys 
            580                 585                 590         


Ser Cys Glu Ile Pro Cys Arg Met Asp Cys Val Leu Ser Glu Trp Thr 
        595                 600                 605             


Glu Trp Ser Ser Cys Ser Gln Ser Cys Ser Asn Lys Asn Ser Asp Gly 
    610                 615                 620                 


Lys Gln Thr Arg Ser Arg Thr Ile Leu Ala Leu Ala Gly Glu Gly Gly 
625                 630                 635                 640 


Lys Pro Cys Pro Pro Ser Gln Ala Leu Gln Glu His Arg Leu Cys Asn 
                645                 650                 655     


Asp His Ser Cys Met Gln Leu His Trp Glu Thr Ser Pro Trp Gly Pro 
            660                 665                 670         


Cys Ser Glu Asp Thr Leu Val Thr Ala Leu Asn Ala Thr Ile Gly Trp 
        675                 680                 685             


Asn Gly Glu Ala Thr Cys Gly Val Gly Ile Gln Thr Arg Arg Val Phe 
    690                 695                 700                 


Cys Val Lys Ser His Val Gly Gln Val Met Thr Lys Arg Cys Pro Asp 
705                 710                 715                 720 


Ser Thr Arg Pro Glu Thr Val Arg Pro Cys Phe Leu Pro Cys Lys Lys 
                725                 730                 735     


Asp Cys Ile Val Thr Ala Phe Ser Glu Trp Thr Pro Cys Pro Arg Met 
            740                 745                 750         


Cys Gln Ala Gly Asn Ala Thr Val Lys Gln Ser Arg Tyr Arg Ile Ile 
        755                 760                 765             


Ile Gln Glu Ala Ala Asn Gly Gly Gln Glu Cys Pro Asp Thr Leu Tyr 
    770                 775                 780                 


Glu Glu Arg Glu Cys Glu Asp Val Ser Leu Cys Pro Val Tyr Arg Trp 
785                 790                 795                 800 


Lys Pro Gln Lys Trp Ser Pro Cys Ile Leu Val Pro Glu Ser Val Trp 
                805                 810                 815     


Gln Gly Ile Thr Gly Ser Ser Glu Ala Cys Gly Lys Gly Leu Gln Thr 
            820                 825                 830         


Arg Ala Val Ser Cys Ile Ser Asp Asp Asn Arg Ser Ala Glu Met Met 
        835                 840                 845             


Glu Cys Leu Lys Gln Thr Asn Gly Met Pro Leu Leu Val Gln Glu Cys 
    850                 855                 860                 


Thr Val Pro Cys Arg Glu Asp Cys Thr Phe Thr Ala Trp Ser Lys Phe 
865                 870                 875                 880 


Thr Pro Cys Ser Thr Asn Cys Glu Ala Thr Lys Ser Arg Arg Arg Gln 
                885                 890                 895     


Leu Thr Gly Lys Ser Arg Lys Lys Glu Lys Cys Gln Asp Ser Asp Leu 
            900                 905                 910         


Tyr Pro Leu Val Glu Thr Glu Leu Cys Pro Cys Asp Glu Phe Ile Ser 
        915                 920                 925             


Gln Pro Tyr Gly Asn Trp Ser Asp Cys Ile Leu Pro Glu Gly Arg Arg 
    930                 935                 940                 


Glu Pro His Arg Gly Leu Arg Val Gln Ala Asp Ser Lys Glu Cys Gly 
945                 950                 955                 960 


Glu Gly Leu Arg Phe Arg Ala Val Ala Cys Ser Asp Lys Asn Gly Arg 
                965                 970                 975     


Pro Val Asp Pro Ser Phe Cys Ser Ser Ser Gly Tyr Ile Gln Glu Lys 
            980                 985                 990         


Cys Val Ile Pro Cys Pro Phe Asp  Cys Lys Leu Ser Asp  Trp Ser Ser 
        995                 1000                 1005             


Trp Gly  Ser Cys Ser Ser Ser  Cys Gly Ile Gly Val  Arg Ile Arg 
    1010                 1015                 1020             


Ser Lys  Trp Leu Lys Glu Lys  Pro Tyr Asn Gly Gly  Arg Pro Cys 
    1025                 1030                 1035             


Pro Lys  Leu Asp Leu Lys Asn  Gln Val His Glu Ala  Val Pro Cys 
    1040                 1045                 1050             


Tyr Ser  Glu Cys Asn Gln Tyr  Ser Trp Val Val Glu  His Trp Ser 
    1055                 1060                 1065             


Ser Cys  Lys Ile Asn Asn Glu  Leu Arg Ser Leu Arg  Cys Gly Gly 
    1070                 1075                 1080             


Gly Thr  Gln Ser Arg Lys Ile  Arg Cys Val Asn Thr  Ala Asp Gly 
    1085                 1090                 1095             


Glu Gly  Gly Ala Val Asp Ser  Asn Leu Cys Asn Gln  Asp Glu Ile 
    1100                 1105                 1110             


Pro Pro  Glu Thr Gln Ser Cys  Ser Leu Met Cys Pro  Asn Glu Cys 
    1115                 1120                 1125             


Val Met  Ser Glu Trp Gly Leu  Trp Ser Lys Cys Pro  Gln Ser Cys 
    1130                 1135                 1140             


Asp Pro  His Thr Met Gln Arg  Arg Thr Arg His Leu  Leu Arg Pro 
    1145                 1150                 1155             


Ser Leu  Asn Ser Arg Thr Cys  Ala Glu Asp Ser Gln  Val Gln Pro 
    1160                 1165                 1170             


Cys Leu  Leu Asn Glu Asn Cys  Phe Gln Phe Gln Tyr  Asn Leu Thr 
    1175                 1180                 1185             


Glu Trp  Ser Thr Cys Gln Leu  Ser Glu Asn Ala Pro  Cys Gly Gln 
    1190                 1195                 1200             


Gly Val  Arg Thr Arg Leu Leu  Ser Cys Val Cys Ser  Asp Gly Lys 
    1205                 1210                 1215             


Pro Val  Ser Met Asp Gln Cys  Glu Gln His Asn Leu  Glu Lys Pro 
    1220                 1225                 1230             


Gln Arg  Met Ser Ile Pro Cys  Leu Val Glu Cys Val  Val Asn Cys 
    1235                 1240                 1245             


Gln Leu  Ser Gly Trp Thr Ala  Trp Thr Glu Cys Ser  Gln Thr Cys 
    1250                 1255                 1260             


Gly His  Gly Gly Arg Met Ser  Arg Thr Arg Phe Ile  Ile Met Pro 
    1265                 1270                 1275             


Thr Gln  Gly Glu Gly Arg Pro  Cys Pro Thr Glu Leu  Thr Gln Glu 
    1280                 1285                 1290             


Lys Thr  Cys Pro Val Thr Pro  Cys Tyr Ser Trp Val  Leu Gly Asn 
    1295                 1300                 1305             


Trp Ser  Ala Cys Lys Leu Glu  Gly Gly Asp Cys Gly  Glu Gly Val 
    1310                 1315                 1320             


Gln Ile  Arg Ser Leu Ser Cys  Met Val His Ser Gly  Ser Ile Ser 
    1325                 1330                 1335             


His Ala  Ala Gly Arg Val Glu  Asp Ala Leu Cys Gly  Glu Met Pro 
    1340                 1345                 1350             


Phe Gln  Asp Ser Ile Leu Lys  Gln Leu Cys Ser Val  Pro Cys Pro 
    1355                 1360                 1365             


Gly Asp  Cys His Leu Thr Glu  Trp Ser Glu Trp Ser  Thr Cys Glu 
    1370                 1375                 1380             


Leu Thr  Cys Ile Asp Gly Arg  Ser Phe Glu Thr Val  Gly Arg Gln 
    1385                 1390                 1395             


Ser Arg  Ser Arg Thr Phe Ile  Ile Gln Ser Phe Glu  Asn Gln Asp 
    1400                 1405                 1410             


Ser Cys  Pro Gln Gln Val Leu  Glu Thr Arg Pro Cys  Thr Gly Gly 
    1415                 1420                 1425             


Lys Cys  Tyr His Tyr Thr Trp  Lys Ala Ser Leu Trp  Asn Asn Asn 
    1430                 1435                 1440             


Glu Arg  Thr Val Trp Cys Gln  Arg Ser Asp Gly Val  Asn Val Thr 
    1445                 1450                 1455             


Gly Gly  Cys Ser Pro Gln Ala  Arg Pro Ala Ala Ile  Arg Gln Cys 
    1460                 1465                 1470             


Ile Pro  Ala Cys Arg Lys Pro  Phe Ser Tyr Cys Thr  Gln Gly Gly 
    1475                 1480                 1485             


Val Cys  Gly Cys Glu Lys Gly  Tyr Thr Glu Ile Met  Lys Ser Asn 
    1490                 1495                 1500             


Gly Phe  Leu Asp Tyr Cys Met  Lys Val Pro Gly Ser  Glu Asp Lys 
    1505                 1510                 1515             


Lys Ala  Asp Val Lys Asn Leu  Ser Gly Lys Asn Arg  Pro Val Asn 
    1520                 1525                 1530             


Ser Lys  Ile His Asp Ile Phe  Lys Gly Trp Ser Leu  Gln Pro Leu 
    1535                 1540                 1545             


Asp Pro  Asp Gly Arg Val Lys  Ile Trp Val Tyr Gly  Val Ser Gly 
    1550                 1555                 1560             


Gly Ala  Phe Leu Ile Met Ile  Phe Leu Ile Phe Thr  Ser Tyr Leu 
    1565                 1570                 1575             


Val Cys  Lys Lys Pro Lys Pro  His Gln Ser Thr Pro  Pro Gln Gln 
    1580                 1585                 1590             


Lys Pro  Leu Thr Leu Ala Tyr  Asp Gly Asp Leu Asp  Met 
    1595                 1600                 1605     


<210>  1021
<211>  798
<212>  PRT
<213>  Homo sapiens

<400>  1021

Met Gly Lys Ala Ser Pro Ala Ser Gly Leu Ser Arg Pro Lys Thr Leu 
1               5                   10                  15      


Val Ser Pro Leu Arg Ser Asn Gln Trp Ser Leu Gln Lys Gly Leu Pro 
            20                  25                  30          


Glu Gln Tyr Tyr Ser Leu Thr Trp Phe Leu Ser Pro Ile Leu Gly Leu 
        35                  40                  45              


Ile Phe Thr Pro Leu Ile Gly Ser Ala Ser Asp Arg Cys Thr Leu Ser 
    50                  55                  60                  


Trp Gly Arg Arg Arg Pro Phe Ile Leu Ala Leu Cys Val Gly Val Leu 
65                  70                  75                  80  


Phe Gly Val Ala Leu Phe Leu Asn Gly Ser Ala Ile Gly Leu Ala Leu 
                85                  90                  95      


Gly Asp Val Pro Asn Arg Gln Pro Ile Gly Ile Val Leu Thr Val Leu 
            100                 105                 110         


Gly Val Val Val Leu Asp Phe Ser Ala Asp Ala Thr Glu Gly Pro Ile 
        115                 120                 125             


Arg Ala Tyr Leu Leu Asp Val Val Asp Ser Glu Glu Gln Asp Met Ala 
    130                 135                 140                 


Leu Asn Ile His Ala Phe Ser Ala Gly Leu Gly Gly Ala Ile Gly Tyr 
145                 150                 155                 160 


Val Leu Gly Gly Leu Asp Trp Thr Gln Thr Phe Leu Gly Ser Trp Phe 
                165                 170                 175     


Arg Thr Gln Asn Gln Val Leu Phe Phe Phe Ala Ala Ile Ile Phe Thr 
            180                 185                 190         


Val Ser Val Ala Leu His Leu Phe Ser Ile Asp Glu Glu Gln Tyr Ser 
        195                 200                 205             


Pro Gln Gln Glu Arg Ser Ala Glu Glu Pro Gly Ala Leu Asp Gly Gly 
    210                 215                 220                 


Glu Pro His Gly Val Pro Ala Phe Pro Asp Glu Val Gln Ser Glu His 
225                 230                 235                 240 


Glu Leu Ala Leu Asp Tyr Pro Asp Val Asp Ile Met Arg Ser Lys Ser 
                245                 250                 255     


Asp Ser Ala Leu His Val Pro Asp Thr Ala Leu Asp Leu Glu Pro Glu 
            260                 265                 270         


Leu Leu Phe Leu His Asp Ile Glu Pro Ser Ile Phe His Asp Ala Ser 
        275                 280                 285             


Tyr Pro Ala Thr Pro Arg Ser Thr Ser Gln Glu Leu Ala Lys Thr Lys 
    290                 295                 300                 


Leu Pro Arg Leu Ala Thr Phe Leu Lys Glu Ala Ala Lys Glu Asp Glu 
305                 310                 315                 320 


Thr Leu Leu Asp Asn His Leu Asn Glu Ala Lys Val Pro Asn Gly Ser 
                325                 330                 335     


Gly Ser Pro Thr Lys Asp Ala Leu Gly Gly Tyr Thr Arg Val Asp Thr 
            340                 345                 350         


Lys Pro Ser Ala Thr Ser Ser Ser Met Arg Arg Arg Arg His Ala Phe 
        355                 360                 365             


Arg Arg Gln Ala Ser Ser Thr Phe Ser Tyr Tyr Gly Lys Leu Gly Ser 
    370                 375                 380                 


His Cys Tyr Arg Tyr Arg Arg Ala Asn Ala Val Val Leu Ile Lys Pro 
385                 390                 395                 400 


Ser Arg Ser Met Ser Asp Leu Tyr Asp Met Gln Lys Arg Gln Arg Gln 
                405                 410                 415     


His Arg His Arg Asn Gln Ser Gly Ala Thr Thr Ser Ser Gly Asp Thr 
            420                 425                 430         


Glu Ser Glu Glu Gly Glu Gly Glu Thr Thr Val Arg Leu Leu Trp Leu 
        435                 440                 445             


Ser Met Leu Lys Met Pro Arg Glu Leu Met Arg Leu Cys Leu Cys His 
    450                 455                 460                 


Leu Leu Thr Trp Phe Ser Val Ile Ala Glu Ala Val Phe Tyr Thr Asp 
465                 470                 475                 480 


Phe Met Gly Gln Val Ile Phe Glu Gly Asp Pro Lys Ala Pro Ser Asn 
                485                 490                 495     


Ser Thr Ala Trp Gln Ala Tyr Asn Ala Gly Val Lys Met Gly Cys Trp 
            500                 505                 510         


Gly Leu Val Ile Tyr Ala Ala Thr Gly Ala Ile Cys Ser Ala Leu Leu 
        515                 520                 525             


Gln Lys Tyr Leu Asp Asn Tyr Asp Leu Ser Val Arg Val Ile Tyr Val 
    530                 535                 540                 


Leu Gly Thr Leu Gly Phe Ser Val Gly Thr Ala Val Met Ala Met Phe 
545                 550                 555                 560 


Pro Asn Val Tyr Val Ala Met Val Thr Ile Ser Thr Met Gly Ile Val 
                565                 570                 575     


Ser Met Ser Ile Ser Tyr Cys Pro Tyr Ala Leu Leu Gly Gln Tyr His 
            580                 585                 590         


Asp Ile Lys Gln Tyr Ile His His Ser Pro Gly Asn Ser Lys Arg Gly 
        595                 600                 605             


Phe Gly Ile Asp Cys Ala Ile Leu Ser Cys Gln Val Tyr Ile Ser Gln 
    610                 615                 620                 


Ile Leu Val Ala Ser Ala Leu Gly Gly Val Val Asp Ala Val Gly Thr 
625                 630                 635                 640 


Val Arg Val Ile Pro Met Val Ala Ser Val Gly Ser Phe Leu Gly Phe 
                645                 650                 655     


Leu Thr Ala Thr Phe Leu Val Ile Tyr Pro Asn Val Ser Glu Glu Ala 
            660                 665                 670         


Lys Glu Glu Gln Lys Gly Leu Ser Ser Pro Leu Ala Gly Glu Gly Arg 
        675                 680                 685             


Ala Gly Gly Asn Ser Glu Lys Pro Thr Val Leu Lys Leu Thr Arg Lys 
    690                 695                 700                 


Glu Gly Leu Gln Gly Pro Val Glu Thr Glu Arg Leu Gln Val Leu Thr 
705                 710                 715                 720 


Ser Val Arg Ser Arg His Ile Gly Trp Cys Arg Ser Cys Trp Arg Val 
                725                 730                 735     


Phe Phe Phe Met Ile Ile Leu Glu Lys Lys Phe Ser Phe Pro Gln Cys 
            740                 745                 750         


Gly Ser Leu Arg Arg Met Thr Tyr Leu Leu Phe Leu Ser Glu Leu Asp 
        755                 760                 765             


Thr Leu Cys Pro Gly Gln Pro Cys Pro Trp Ala Ala Thr Ala His Gln 
    770                 775                 780                 


Ser Trp Glu Glu Ala Gly Pro Gly Gly Leu Gly Arg Arg Gln 
785                 790                 795             


<210>  1022
<211>  1489
<212>  PRT
<213>  Homo sapiens

<400>  1022

Met Arg Gln Val Leu Trp Leu Cys Asn Val Cys Val Thr Ala Arg Glu 
1               5                   10                  15      


Thr Arg His His Leu His Leu Pro Ala Ile Leu Asp Lys Met Pro Ala 
            20                  25                  30          


Pro Gly Ala Leu Ile Leu Leu Ala Ala Val Ser Ala Ser Gly Cys Leu 
        35                  40                  45              


Ala Ser Pro Ala His Pro Asp Gly Phe Ala Leu Gly Arg Ala Pro Leu 
    50                  55                  60                  


Ala Pro Pro Tyr Ala Val Val Leu Ile Ser Cys Ser Gly Leu Leu Ala 
65                  70                  75                  80  


Phe Ile Phe Leu Leu Leu Thr Cys Leu Cys Cys Lys Arg Gly Asp Val 
                85                  90                  95      


Gly Phe Lys Glu Phe Glu Asn Pro Glu Gly Glu Asp Cys Ser Gly Glu 
            100                 105                 110         


Tyr Thr Pro Pro Ala Glu Glu Thr Ser Ser Ser Gln Ser Leu Pro Asp 
        115                 120                 125             


Val Tyr Ile Leu Pro Leu Ala Glu Val Ser Leu Pro Met Pro Ala Pro 
    130                 135                 140                 


Gln Pro Ser His Ser Asp Met Thr Thr Pro Leu Gly Leu Ser Arg Gln 
145                 150                 155                 160 


His Leu Ser Tyr Leu Gln Glu Ile Gly Ser Gly Trp Phe Gly Lys Val 
                165                 170                 175     


Ile Leu Gly Glu Ile Phe Ser Asp Tyr Thr Pro Ala Gln Val Val Val 
            180                 185                 190         


Lys Glu Leu Arg Ala Ser Ala Gly Pro Leu Glu Gln Arg Lys Phe Ile 
        195                 200                 205             


Ser Glu Ala Gln Pro Tyr Arg Ser Leu Gln His Pro Asn Val Leu Gln 
    210                 215                 220                 


Cys Leu Gly Leu Cys Val Glu Thr Leu Pro Phe Leu Leu Ile Met Glu 
225                 230                 235                 240 


Phe Cys Gln Leu Gly Asp Leu Lys Arg Tyr Leu Arg Ala Gln Arg Pro 
                245                 250                 255     


Pro Glu Gly Leu Ser Pro Glu Leu Pro Pro Arg Asp Leu Arg Thr Leu 
            260                 265                 270         


Gln Arg Met Gly Leu Glu Ile Ala Arg Gly Leu Ala His Leu His Ser 
        275                 280                 285             


His Asn Tyr Val His Ser Asp Leu Ala Leu Arg Asn Cys Leu Leu Thr 
    290                 295                 300                 


Ser Asp Leu Thr Val Arg Ile Gly Asp Tyr Gly Leu Ala His Ser Asn 
305                 310                 315                 320 


Tyr Lys Glu Asp Tyr Tyr Leu Thr Pro Glu Arg Leu Trp Ile Pro Leu 
                325                 330                 335     


Arg Trp Ala Ala Pro Glu Leu Leu Gly Glu Leu His Gly Thr Phe Met 
            340                 345                 350         


Val Val Asp Gln Ser Arg Glu Ser Asn Ile Trp Ser Leu Gly Val Thr 
        355                 360                 365             


Leu Trp Glu Leu Phe Glu Phe Gly Ala Gln Pro Tyr Arg His Leu Ser 
    370                 375                 380                 


Asp Glu Glu Val Leu Ala Phe Val Val Arg Gln Gln His Val Lys Leu 
385                 390                 395                 400 


Ala Arg Pro Arg Leu Lys Leu Pro Tyr Ala Asp Tyr Trp Tyr Asp Ile 
                405                 410                 415     


Leu Gln Ser Cys Trp Arg Pro Pro Ala Gln Arg Pro Ser Ala Ser Asp 
            420                 425                 430         


Leu Gln Leu Gln Leu Thr Tyr Leu Leu Ser Glu Arg Pro Pro Arg Pro 
        435                 440                 445             


Pro Pro Pro Pro Pro Pro Pro Arg Asp Gly Pro Phe Pro Trp Pro Trp 
    450                 455                 460                 


Pro Pro Ala His Ser Ala Pro Arg Pro Gly Thr Leu Ser Ser Pro Phe 
465                 470                 475                 480 


Pro Leu Leu Asp Gly Phe Pro Gly Ala Asp Pro Asp Asp Val Leu Thr 
                485                 490                 495     


Val Thr Glu Ser Ser Arg Gly Leu Asn Leu Glu Cys Leu Trp Glu Lys 
            500                 505                 510         


Ala Arg Arg Gly Ala Gly Arg Gly Gly Gly Ala Pro Ala Trp Gln Pro 
        515                 520                 525             


Ala Ser Ala Pro Pro Ala Pro His Ala Asn Pro Ser Asn Pro Phe Tyr 
    530                 535                 540                 


Glu Ala Leu Ser Thr Pro Ser Val Leu Pro Val Ile Ser Ala Arg Ser 
545                 550                 555                 560 


Pro Ser Val Ser Ser Glu Tyr Tyr Ile Arg Leu Glu Glu His Gly Ser 
                565                 570                 575     


Pro Pro Glu Pro Leu Phe Pro Asn Asp Trp Asp Pro Leu Asp Pro Gly 
            580                 585                 590         


Val Pro Ala Pro Gln Ala Pro Gln Ala Pro Ser Glu Val Pro Gln Leu 
        595                 600                 605             


Val Ser Glu Thr Trp Ala Ser Pro Leu Phe Pro Ala Pro Arg Pro Phe 
    610                 615                 620                 


Pro Ala Gln Ser Ser Ala Ser Gly Ser Phe Leu Leu Ser Gly Trp Asp 
625                 630                 635                 640 


Pro Glu Gly Arg Gly Ala Gly Glu Thr Leu Ala Gly Asp Pro Ala Glu 
                645                 650                 655     


Val Leu Gly Glu Arg Gly Thr Ala Pro Trp Val Glu Glu Glu Glu Glu 
            660                 665                 670         


Glu Glu Glu Gly Ser Ser Pro Gly Glu Asp Ser Ser Ser Leu Gly Gly 
        675                 680                 685             


Gly Pro Ser Arg Arg Gly Pro Leu Pro Cys Pro Leu Cys Ser Arg Glu 
    690                 695                 700                 


Gly Ala Cys Ser Cys Leu Pro Leu Glu Arg Gly Asp Ala Val Ala Gly 
705                 710                 715                 720 


Trp Gly Gly His Pro Ala Leu Gly Cys Pro His Pro Pro Glu Asp Asp 
                725                 730                 735     


Ser Ser Leu Arg Ala Glu Arg Gly Ser Leu Ala Asp Leu Pro Met Ala 
            740                 745                 750         


Pro Pro Ala Ser Ala Pro Pro Glu Phe Leu Asp Pro Leu Met Gly Ala 
        755                 760                 765             


Ala Ala Pro Gln Tyr Pro Gly Arg Gly Pro Pro Pro Ala Pro Pro Pro 
    770                 775                 780                 


Pro Pro Pro Pro Pro Arg Ala Pro Ala Asp Pro Ala Ala Ser Pro Asp 
785                 790                 795                 800 


Pro Pro Ser Ala Val Ala Ser Pro Gly Ser Gly Leu Ser Ser Pro Gly 
                805                 810                 815     


Pro Lys Pro Gly Asp Ser Gly Tyr Glu Thr Glu Thr Pro Phe Ser Pro 
            820                 825                 830         


Glu Gly Ala Phe Pro Gly Gly Gly Ala Ala Glu Glu Glu Gly Val Pro 
        835                 840                 845             


Arg Pro Arg Ala Pro Pro Glu Pro Pro Asp Pro Gly Ala Pro Arg Pro 
    850                 855                 860                 


Pro Pro Asp Pro Gly Pro Leu Pro Leu Pro Gly Pro Arg Glu Lys Pro 
865                 870                 875                 880 


Thr Phe Val Val Gln Val Ser Thr Glu Gln Leu Leu Met Ser Leu Arg 
                885                 890                 895     


Glu Asp Val Thr Arg Asn Leu Leu Gly Glu Lys Gly Ala Thr Ala Arg 
            900                 905                 910         


Glu Thr Gly Pro Arg Lys Ala Gly Arg Gly Pro Gly Asn Arg Glu Lys 
        915                 920                 925             


Val Pro Gly Leu Asn Arg Asp Pro Thr Val Leu Gly Asn Gly Lys Gln 
    930                 935                 940                 


Ala Pro Ser Leu Ser Leu Pro Val Asn Gly Val Thr Val Leu Glu Asn 
945                 950                 955                 960 


Gly Asp Gln Arg Ala Pro Gly Ile Glu Glu Lys Ala Ala Glu Asn Gly 
                965                 970                 975     


Ala Leu Gly Ser Pro Glu Arg Glu Glu Lys Val Leu Glu Asn Gly Glu 
            980                 985                 990         


Leu Thr Pro Pro Arg Arg Glu Glu  Lys Ala Leu Glu Asn  Gly Glu Leu 
        995                 1000                 1005             


Arg Ser  Pro Glu Ala Gly Glu  Lys Val Leu Val Asn  Gly Gly Leu 
    1010                 1015                 1020             


Thr Pro  Pro Lys Ser Glu Asp  Lys Val Ser Glu Asn  Gly Gly Leu 
    1025                 1030                 1035             


Arg Phe  Pro Arg Asn Thr Glu  Arg Pro Pro Glu Thr  Gly Pro Trp 
    1040                 1045                 1050             


Arg Ala  Pro Gly Pro Trp Glu  Lys Thr Pro Glu Ser  Trp Gly Pro 
    1055                 1060                 1065             


Ala Pro  Thr Ile Gly Glu Pro  Ala Pro Glu Thr Ser  Leu Glu Arg 
    1070                 1075                 1080             


Ala Pro  Ala Pro Ser Ala Val  Val Ser Ser Arg Asn  Gly Gly Glu 
    1085                 1090                 1095             


Thr Ala  Pro Gly Pro Leu Gly  Pro Ala Pro Lys Asn  Gly Thr Leu 
    1100                 1105                 1110             


Glu Pro  Gly Thr Glu Arg Arg  Ala Pro Glu Thr Gly  Gly Ala Pro 
    1115                 1120                 1125             


Arg Ala  Pro Gly Ala Gly Arg  Leu Asp Leu Gly Ser  Gly Gly Arg 
    1130                 1135                 1140             


Ala Pro  Val Gly Thr Gly Thr  Ala Pro Gly Gly Gly  Pro Gly Ser 
    1145                 1150                 1155             


Gly Val  Asp Ala Lys Ala Gly  Trp Val Asp Asn Thr  Arg Pro Gln 
    1160                 1165                 1170             


Pro Pro  Pro Pro Pro Leu Pro  Pro Pro Pro Glu Ala  Gln Pro Arg 
    1175                 1180                 1185             


Arg Leu  Glu Pro Ala Pro Pro  Arg Ala Arg Pro Glu  Val Ala Pro 
    1190                 1195                 1200             


Glu Gly  Glu Pro Gly Ala Pro  Asp Ser Arg Ala Gly  Gly Asp Thr 
    1205                 1210                 1215             


Ala Leu  Ser Gly Asp Gly Asp  Pro Pro Lys Pro Glu  Arg Lys Gly 
    1220                 1225                 1230             


Pro Glu  Met Pro Arg Leu Phe  Leu Asp Leu Gly Pro  Pro Gln Gly 
    1235                 1240                 1245             


Asn Ser  Glu Gln Ile Lys Ala  Arg Leu Ser Arg Leu  Ser Leu Ala 
    1250                 1255                 1260             


Leu Pro  Pro Leu Thr Leu Thr  Pro Phe Pro Gly Pro  Gly Pro Arg 
    1265                 1270                 1275             


Arg Pro  Pro Trp Glu Gly Ala  Asp Ala Gly Ala Ala  Gly Gly Glu 
    1280                 1285                 1290             


Ala Gly  Gly Ala Gly Ala Pro  Gly Pro Ala Glu Glu  Asp Gly Glu 
    1295                 1300                 1305             


Asp Glu  Asp Glu Asp Glu Glu  Glu Asp Glu Glu Ala  Ala Ala Pro 
    1310                 1315                 1320             


Gly Ala  Ala Ala Gly Pro Arg  Gly Pro Gly Arg Ala  Arg Ala Ala 
    1325                 1330                 1335             


Pro Val  Pro Val Val Val Ser  Ser Ala Asp Ala Asp  Ala Ala Arg 
    1340                 1345                 1350             


Pro Leu  Arg Gly Leu Leu Lys  Ser Pro Arg Gly Ala  Asp Glu Pro 
    1355                 1360                 1365             


Glu Asp  Ser Glu Leu Glu Arg  Lys Arg Lys Met Val  Ser Phe His 
    1370                 1375                 1380             


Gly Asp  Val Thr Val Tyr Leu  Phe Asp Gln Glu Thr  Pro Thr Asn 
    1385                 1390                 1395             


Glu Leu  Ser Val Gln Ala Pro  Pro Glu Gly Asp Thr  Asp Pro Ser 
    1400                 1405                 1410             


Thr Pro  Pro Ala Pro Pro Thr  Pro Pro His Pro Ala  Thr Pro Gly 
    1415                 1420                 1425             


Asp Gly  Phe Pro Ser Asn Asp  Ser Gly Phe Gly Gly  Ser Phe Glu 
    1430                 1435                 1440             


Trp Ala  Glu Asp Phe Pro Leu  Leu Pro Pro Pro Gly  Pro Pro Leu 
    1445                 1450                 1455             


Cys Phe  Ser Arg Phe Ser Val  Ser Pro Ala Leu Glu  Thr Pro Gly 
    1460                 1465                 1470             


Pro Pro  Ala Arg Ala Pro Asp  Ala Arg Pro Ala Gly  Pro Val Glu 
    1475                 1480                 1485             


Asn 
    


<210>  1023
<211>  1130
<212>  PRT
<213>  Homo sapiens

<400>  1023

Met Gln Phe Pro Ser Pro Pro Ala Ala Arg Ser Ser Pro Ala Pro Gln 
1               5                   10                  15      


Ala Ala Ser Ser Ser Glu Ala Ala Ala Pro Ala Thr Gly Gln Pro Gly 
            20                  25                  30          


Pro Ser Cys Pro Val Pro Gly Thr Ser Arg Arg Gly Arg Pro Gly Thr 
        35                  40                  45              


Pro Pro Ala Gly Arg Val Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp 
    50                  55                  60                  


Val Asp Lys Asp Pro His Pro Thr Gln Asn Thr Cys Leu Arg Cys Arg 
65                  70                  75                  80  


His Phe Ser Leu Arg Glu Arg Lys Arg Glu Pro Arg Arg Thr Met Gly 
                85                  90                  95      


Gly Cys Glu Val Arg Glu Phe Leu Leu Gln Phe Gly Phe Phe Leu Pro 
            100                 105                 110         


Leu Leu Thr Ala Trp Pro Gly Asp Cys Ser His Val Ser Asn Asn Gln 
        115                 120                 125             


Val Val Leu Leu Asp Thr Thr Thr Val Leu Gly Glu Leu Gly Trp Lys 
    130                 135                 140                 


Thr Tyr Pro Leu Asn Gly Trp Asp Ala Ile Thr Glu Met Asp Glu His 
145                 150                 155                 160 


Asn Arg Pro Ile His Thr Tyr Gln Val Cys Asn Val Met Glu Pro Asn 
                165                 170                 175     


Gln Asn Asn Trp Leu Arg Thr Asn Trp Ile Ser Arg Asp Ala Ala Gln 
            180                 185                 190         


Lys Ile Tyr Val Glu Met Lys Phe Thr Leu Arg Asp Cys Asn Ser Ile 
        195                 200                 205             


Pro Trp Val Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Phe Tyr Met 
    210                 215                 220                 


Glu Ser Asp Glu Ser His Gly Ile Lys Phe Lys Pro Asn Gln Tyr Thr 
225                 230                 235                 240 


Lys Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Met Asp Leu 
                245                 250                 255     


Gly Asp Arg Ile Leu Lys Leu Asn Thr Glu Ile Arg Glu Val Gly Pro 
            260                 265                 270         


Ile Glu Arg Lys Gly Phe Tyr Leu Ala Phe Gln Asp Ile Gly Ala Cys 
        275                 280                 285             


Ile Ala Leu Val Ser Val Arg Val Phe Tyr Lys Lys Cys Pro Phe Thr 
    290                 295                 300                 


Val Arg Asn Leu Ala Met Phe Pro Asp Thr Ile Pro Arg Val Asp Ser 
305                 310                 315                 320 


Ser Ser Leu Val Glu Val Arg Gly Ser Cys Val Lys Ser Ala Glu Glu 
                325                 330                 335     


Arg Asp Thr Pro Lys Leu Tyr Cys Gly Ala Asp Gly Asp Trp Leu Val 
            340                 345                 350         


Pro Leu Gly Arg Cys Ile Cys Ser Thr Gly Tyr Glu Glu Ile Glu Gly 
        355                 360                 365             


Ser Cys His Ala Cys Arg Pro Gly Phe Tyr Lys Ala Phe Ala Gly Asn 
    370                 375                 380                 


Thr Lys Cys Ser Lys Cys Pro Pro His Ser Leu Thr Tyr Met Glu Ala 
385                 390                 395                 400 


Thr Ser Val Cys Gln Cys Glu Lys Gly Tyr Phe Arg Ala Glu Lys Asp 
                405                 410                 415     


Pro Pro Ser Met Ala Cys Thr Arg Pro Pro Ser Ala Pro Arg Asn Val 
            420                 425                 430         


Val Phe Asn Ile Asn Glu Thr Ala Leu Ile Leu Glu Trp Ser Pro Pro 
        435                 440                 445             


Ser Asp Thr Gly Gly Arg Lys Asp Leu Thr Tyr Ser Val Ile Cys Lys 
    450                 455                 460                 


Lys Cys Gly Leu Asp Thr Ser Gln Cys Glu Asp Cys Gly Gly Gly Leu 
465                 470                 475                 480 


Arg Phe Ile Pro Arg His Thr Gly Leu Ile Asn Asn Ser Val Ile Val 
                485                 490                 495     


Leu Asp Phe Val Ser His Val Asn Tyr Thr Phe Glu Ile Glu Ala Met 
            500                 505                 510         


Asn Gly Val Ser Glu Leu Ser Phe Ser Pro Lys Pro Phe Thr Ala Ile 
        515                 520                 525             


Thr Val Thr Thr Asp Gln Asp Ala Pro Ser Leu Ile Gly Val Val Arg 
    530                 535                 540                 


Lys Asp Trp Ala Ser Gln Asn Ser Ile Ala Leu Ser Trp Gln Ala Pro 
545                 550                 555                 560 


Ala Phe Ser Asn Gly Ala Ile Leu Asp Tyr Glu Ile Lys Tyr Tyr Glu 
                565                 570                 575     


Lys Glu His Glu Gln Leu Thr Tyr Ser Ser Thr Arg Ser Lys Ala Pro 
            580                 585                 590         


Ser Val Ile Ile Thr Gly Leu Lys Pro Ala Thr Lys Tyr Val Phe His 
        595                 600                 605             


Ile Arg Val Arg Thr Ala Thr Gly Tyr Ser Gly Tyr Ser Gln Lys Phe 
    610                 615                 620                 


Glu Phe Glu Thr Gly Asp Glu Thr Ser Asp Met Ala Ala Glu Gln Gly 
625                 630                 635                 640 


Gln Ile Leu Val Ile Ala Thr Ala Ala Val Gly Gly Phe Thr Leu Leu 
                645                 650                 655     


Val Ile Leu Thr Leu Phe Phe Leu Ile Thr Gly Arg Cys Gln Trp Tyr 
            660                 665                 670         


Ile Lys Ala Lys Met Lys Ser Glu Glu Lys Arg Arg Asn His Leu Gln 
        675                 680                 685             


Asn Gly His Leu Arg Phe Pro Gly Ile Lys Thr Tyr Ile Asp Pro Asp 
    690                 695                 700                 


Thr Tyr Glu Asp Pro Ser Leu Ala Val His Glu Phe Ala Lys Glu Ile 
705                 710                 715                 720 


Asp Pro Ser Arg Ile Arg Ile Glu Arg Val Ile Gly Ala Gly Glu Phe 
                725                 730                 735     


Gly Glu Val Cys Ser Gly Arg Leu Lys Thr Pro Gly Lys Arg Glu Ile 
            740                 745                 750         


Pro Val Ala Ile Lys Thr Leu Lys Gly Gly His Met Asp Arg Gln Arg 
        755                 760                 765             


Arg Asp Phe Leu Arg Glu Ala Ser Ile Met Gly Gln Phe Asp His Pro 
    770                 775                 780                 


Asn Ile Ile Arg Leu Glu Gly Val Val Thr Lys Arg Ser Phe Pro Ala 
785                 790                 795                 800 


Ile Gly Val Glu Ala Phe Cys Pro Ser Phe Leu Arg Ala Gly Phe Leu 
                805                 810                 815     


Asn Ser Ile Gln Ala Pro His Pro Val Pro Gly Gly Gly Ser Leu Pro 
            820                 825                 830         


Pro Arg Ile Pro Ala Gly Arg Pro Val Met Ile Val Val Glu Tyr Met 
        835                 840                 845             


Glu Asn Gly Ser Leu Asp Ser Phe Leu Arg Lys His Asp Gly His Phe 
    850                 855                 860                 


Thr Val Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ser Gly Met 
865                 870                 875                 880 


Lys Tyr Leu Ser Asp Met Gly Tyr Val His Arg Asp Leu Ala Ala Arg 
                885                 890                 895     


Asn Ile Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly 
            900                 905                 910         


Leu Ser Arg Val Leu Glu Asp Asp Pro Glu Ala Ala Tyr Thr Thr Thr 
        915                 920                 925             


Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr 
    930                 935                 940                 


Arg Lys Phe Ser Ser Ala Ser Asp Ala Trp Ser Tyr Gly Ile Val Met 
945                 950                 955                 960 


Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Glu Met Ser Asn 
                965                 970                 975     


Gln Asp Val Ile Leu Ser Ile Glu Glu Gly Tyr Arg Leu Pro Ala Pro 
            980                 985                 990         


Met Gly Cys Pro Ala Ser Leu His  Gln Leu Met Leu His  Cys Trp Gln 
        995                 1000                 1005             


Lys Glu  Arg Asn His Arg Pro  Lys Phe Thr Asp Ile  Val Ser Phe 
    1010                 1015                 1020             


Leu Asp  Lys Leu Ile Arg Asn  Pro Ser Ala Leu His  Thr Leu Val 
    1025                 1030                 1035             


Glu Asp  Ile Leu Val Met Pro  Glu Ser Pro Gly Glu  Val Pro Glu 
    1040                 1045                 1050             


Tyr Pro  Leu Phe Val Thr Val  Gly Asp Trp Leu Asp  Ser Ile Lys 
    1055                 1060                 1065             


Met Gly  Gln Tyr Lys Asn Asn  Phe Val Ala Ala Gly  Phe Thr Thr 
    1070                 1075                 1080             


Phe Asp  Leu Ile Ser Arg Met  Ser Ile Asp Asp Ile  Arg Arg Ile 
    1085                 1090                 1095             


Gly Val  Ile Leu Ile Gly His  Gln Arg Arg Ile Val  Ser Ser Ile 
    1100                 1105                 1110             


Gln Thr  Leu Arg Leu His Met  Met His Ile Gln Glu  Lys Gly Phe 
    1115                 1120                 1125             


His Val  
    1130 


<210>  1024
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  1024

Met Ala Val Ser Glu Arg Arg Gly Leu Gly Arg Gly Ser Pro Ala Glu 
1               5                   10                  15      


Trp Gly Gln Arg Leu Leu Leu Val Leu Leu Leu Gly Gly Cys Ser Gly 
            20                  25                  30          


Arg Ile His Gln Leu Ala Leu Thr Gly Glu Lys Arg Ala Asp Ile Gln 
        35                  40                  45              


Leu Asn Ser Phe Gly Phe Tyr Thr Asn Gly Ser Leu Glu Val Glu Leu 
    50                  55                  60                  


Ser Val Leu Arg Leu Gly Leu Arg Glu Ala Glu Glu Lys Ser Leu Leu 
65                  70                  75                  80  


Val Gly Phe Ser Leu Ser Arg Val Arg Ser Gly Arg Val Arg Ser Tyr 
                85                  90                  95      


Ser Thr Arg Asp Phe Gln Asp Cys Pro Leu Gln Lys Asn Ser Ser Ser 
            100                 105                 110         


Phe Leu Val Leu Phe Leu Ile Asn Thr Lys Asp Leu Gln Val Gln Val 
        115                 120                 125             


Arg Lys Tyr Gly Glu Gln Lys Thr Leu Phe Ile Phe Pro Gly Leu Leu 
    130                 135                 140                 


Pro Glu Ala Pro Ser Lys Pro Gly Leu Pro Lys Pro Gln Ala Thr Val 
145                 150                 155                 160 


Pro Arg Lys Val Asp Gly Gly Gly Thr Ser Ala Ala Ser Lys Pro Lys 
                165                 170                 175     


Ser Thr Pro Ala Val Ile Gln Gly Pro Ser Gly Lys Asp Lys Asp Leu 
            180                 185                 190         


Val Leu Gly Leu Ser His Leu Asn Asn Ser Tyr Asn Phe Ser Phe His 
        195                 200                 205             


Val Val Ile Gly Ser Gln Ala Glu Glu Gly Gln Tyr Ser Leu Asn Phe 
    210                 215                 220                 


His Asn Cys Asn Asn Ser Val Pro Gly Lys Glu His Pro Phe Asp Ile 
225                 230                 235                 240 


Thr Val Met Ile Arg Glu Lys Asn Pro Asp Gly Phe Leu Ser Ala Ala 
                245                 250                 255     


Glu Met Pro Leu Phe Lys Leu Tyr Met Val Met Ser Ala Cys Phe Leu 
            260                 265                 270         


Ala Ala Gly Ile Phe Trp Val Ser Ile Leu Cys Arg Asn Thr Tyr Ser 
        275                 280                 285             


Val Phe Lys Ile His Trp Leu Met Ala Ala Leu Ala Phe Thr Lys Ser 
    290                 295                 300                 


Ile Ser Leu Leu Phe His Ser Ile Asn Tyr Tyr Phe Ile Asn Ser Gln 
305                 310                 315                 320 


Gly His Pro Ile Glu Gly Leu Ala Val Met Tyr Tyr Ile Ala His Leu 
                325                 330                 335     


Leu Lys Gly Ala Leu Leu Phe Ile Thr Ile Ala Leu Ile Gly Ser Gly 
            340                 345                 350         


Trp Ala Phe Ile Lys Tyr Val Leu Ser Asp Lys Glu Lys Lys Val Phe 
        355                 360                 365             


Gly Ile Val Ile Pro Met Gln Val Leu Ala Asn Val Ala Tyr Ile Ile 
    370                 375                 380                 


Ile Glu Ser Arg Glu Glu Gly Ala Ser Asp Tyr Val Leu Trp Lys Glu 
385                 390                 395                 400 


Ile Leu Phe Leu Val Asp Leu Ile Cys Cys Gly Ala Ile Leu Phe Pro 
                405                 410                 415     


Val Val Trp Ser Ile Arg His Leu Gln Asp Ala Ser Gly Thr Asp Gly 
            420                 425                 430         


Lys Val Ala Val Asn Leu Ala Lys Leu Lys Leu Phe Arg His Tyr Tyr 
        435                 440                 445             


Val Met Val Ile Cys Tyr Val Tyr Phe Thr Arg Ile Ile Ala Ile Leu 
    450                 455                 460                 


Leu Gln Val Ala Val Pro Phe Gln Trp Gln Trp Leu Tyr Gln Leu Leu 
465                 470                 475                 480 


Val Glu Gly Ser Thr Leu Ala Phe Phe Val Leu Thr Gly Tyr Lys Phe 
                485                 490                 495     


Gln Pro Thr Gly Asn Asn Pro Tyr Leu Gln Leu Pro Gln Glu Asp Glu 
            500                 505                 510         


Glu Asp Val Gln Met Glu Gln Val Met Thr Asp Ser Gly Phe Arg Glu 
        515                 520                 525             


Gly Leu Ser Lys Val Asn Lys Thr Ala Ser Gly Arg Glu Leu Leu 
    530                 535                 540             


<210>  1025
<211>  484
<212>  PRT
<213>  Homo sapiens

<400>  1025

Met Asp Val Lys Ala Ala Pro Asn Gly Val Ala Thr Ile Glu Asp Arg 
1               5                   10                  15      


Ile Leu Arg Ile Thr Gly Tyr Tyr Gly Tyr Tyr Pro Gly Tyr Ser Ser 
            20                  25                  30          


Gln Lys Ser Thr Ser Arg Ser Ser Val Thr Arg Cys Lys Pro Gly Ala 
        35                  40                  45              


Asn Cys Pro Ser Ser His Ser Gly Ile Ser Arg Gln Leu Ser Pro Leu 
    50                  55                  60                  


Ser Val Thr Glu Asp Ser Ser Ala Pro Ile Leu Glu Leu Gln Asn Gln 
65                  70                  75                  80  


Gly Ser Ser Gly Val Cys Gly His Arg Val Glu Arg Gln Asn Arg Ser 
                85                  90                  95      


Asp Asp Gly Thr Gln Thr His Ser Glu Asn Ser Ser Gln Glu Asn Arg 
            100                 105                 110         


Ile Lys Ala Arg Cys Leu Ser Cys Thr Ser Met Val Leu Lys Gly Ile 
        115                 120                 125             


Trp Gly Leu Leu Ile Ile Leu Ser Val Ser Ser Ser Trp Val Gly Thr 
    130                 135                 140                 


Thr Gln Ile Val Lys Ile Thr Tyr Lys Asn Phe Tyr Cys Pro Phe Phe 
145                 150                 155                 160 


Met Thr Trp Phe Ser Thr Asn Trp Asn Ile Met Phe Phe Pro Val Tyr 
                165                 170                 175     


Tyr Ser Gly His Leu Ala Thr Ala Gln Glu Lys Gln Ser Pro Met Lys 
            180                 185                 190         


Lys Phe Arg Glu Cys Ser Arg Ile Phe Gly Glu Asp Gly Leu Thr Leu 
        195                 200                 205             


Lys Leu Phe Leu Lys Arg Thr Ala Pro Phe Ser Ile Leu Trp Thr Leu 
    210                 215                 220                 


Thr Asn Tyr Leu Tyr Leu Leu Ala Leu Lys Lys Leu Thr Ala Thr Asp 
225                 230                 235                 240 


Val Ser Ala Leu Phe Cys Cys Asn Lys Ala Phe Val Phe Leu Leu Ser 
                245                 250                 255     


Trp Ile Val Leu Lys Asp Arg Phe Met Gly Val Arg Ile Val Ala Ala 
            260                 265                 270         


Ile Met Ala Ile Thr Gly Ile Val Met Met Ala Tyr Ala Asp Asn Phe 
        275                 280                 285             


His Ala Asp Ser Ile Ile Gly Val Ala Phe Ala Val Gly Ser Ala Ser 
    290                 295                 300                 


Thr Ser Ala Leu Tyr Lys Val Leu Phe Lys Met Phe Leu Gly Ser Ala 
305                 310                 315                 320 


Asn Phe Gly Glu Ala Ala His Phe Val Ser Thr Leu Gly Phe Phe Asn 
                325                 330                 335     


Leu Ile Phe Ile Ser Phe Thr Pro Val Ile Leu Tyr Phe Thr Lys Val 
            340                 345                 350         


Glu His Trp Ser Ser Phe Ala Ala Leu Pro Trp Gly Cys Leu Cys Gly 
        355                 360                 365             


Met Ala Gly Leu Trp Leu Ala Phe Asn Ile Leu Val Asn Val Gly Val 
    370                 375                 380                 


Val Leu Thr Tyr Pro Ile Leu Ile Ser Ile Gly Thr Val Leu Ser Val 
385                 390                 395                 400 


Pro Gly Asn Ala Ala Val Asp Leu Leu Lys Gln Glu Val Ile Phe Asn 
                405                 410                 415     


Val Val Arg Leu Ala Ala Thr Ile Ile Ile Cys Ile Gly Phe Leu Leu 
            420                 425                 430         


Met Leu Leu Pro Glu Glu Trp Asp Glu Ile Thr Leu Arg Phe Ile Asn 
        435                 440                 445             


Ser Leu Lys Glu Lys Lys Ser Glu Glu His Val Asp Asp Val Thr Asp 
    450                 455                 460                 


Pro Ser Ile His Leu Arg Gly Arg Gly Arg Ala Asn Gly Thr Val Ser 
465                 470                 475                 480 


Ile Pro Leu Ala 
                


<210>  1026
<211>  713
<212>  PRT
<213>  Homo sapiens

<400>  1026

Met Ala Arg Ala Arg Gly Ser Pro Cys Pro Pro Leu Pro Pro Gly Arg 
1               5                   10                  15      


Met Ser Trp Pro His Gly Ala Leu Leu Phe Leu Trp Leu Phe Ser Pro 
            20                  25                  30          


Pro Leu Gly Ala Gly Gly Gly Gly Val Ala Val Thr Ser Ala Ala Gly 
        35                  40                  45              


Gly Gly Ser Pro Pro Ala Thr Ser Cys Pro Val Ala Cys Ser Cys Ser 
    50                  55                  60                  


Asn Gln Ala Ser Arg Val Ile Cys Thr Arg Arg Asp Leu Ala Glu Val 
65                  70                  75                  80  


Pro Ala Ser Ile Pro Val Asn Thr Arg Tyr Leu Asn Leu Gln Glu Asn 
                85                  90                  95      


Gly Ile Gln Val Ile Arg Thr Asp Thr Phe Lys His Leu Arg His Leu 
            100                 105                 110         


Glu Ile Leu Gln Leu Ser Lys Asn Leu Val Arg Lys Ile Glu Val Gly 
        115                 120                 125             


Ala Phe Asn Gly Leu Pro Ser Leu Asn Thr Leu Glu Leu Phe Asp Asn 
    130                 135                 140                 


Arg Leu Thr Thr Val Pro Thr Gln Ala Phe Glu Tyr Leu Ser Lys Leu 
145                 150                 155                 160 


Arg Glu Leu Trp Leu Arg Asn Asn Pro Ile Glu Ser Ile Pro Ser Tyr 
                165                 170                 175     


Ala Phe Asn Arg Val Pro Ser Leu Arg Arg Leu Asp Leu Gly Glu Leu 
            180                 185                 190         


Lys Arg Leu Glu Tyr Ile Ser Glu Ala Ala Phe Glu Gly Leu Val Asn 
        195                 200                 205             


Leu Arg Tyr Leu Asn Leu Gly Met Cys Asn Leu Lys Asp Ile Pro Asn 
    210                 215                 220                 


Leu Thr Ala Leu Val Arg Leu Glu Glu Leu Glu Leu Ser Gly Asn Arg 
225                 230                 235                 240 


Leu Asp Leu Ile Arg Pro Gly Ser Phe Gln Gly Leu Thr Ser Leu Arg 
                245                 250                 255     


Lys Leu Trp Leu Met His Ala Gln Val Ala Thr Ile Glu Arg Asn Ala 
            260                 265                 270         


Phe Asp Asp Leu Lys Ser Leu Glu Glu Leu Asn Leu Ser His Asn Asn 
        275                 280                 285             


Leu Met Ser Leu Pro His Asp Leu Phe Thr Pro Leu His Arg Leu Glu 
    290                 295                 300                 


Arg Val His Leu Asn His Asn Pro Trp His Cys Asn Cys Asp Val Leu 
305                 310                 315                 320 


Trp Leu Ser Trp Trp Leu Lys Glu Thr Val Pro Ser Asn Thr Thr Cys 
                325                 330                 335     


Cys Ala Arg Cys His Ala Pro Ala Gly Leu Lys Gly Arg Tyr Ile Gly 
            340                 345                 350         


Glu Leu Asp Gln Ser His Phe Thr Cys Tyr Ala Pro Val Ile Val Glu 
        355                 360                 365             


Pro Pro Thr Asp Leu Asn Val Thr Glu Gly Met Ala Ala Glu Leu Lys 
    370                 375                 380                 


Cys Arg Thr Gly Thr Ser Met Thr Ser Val Asn Trp Leu Thr Pro Asn 
385                 390                 395                 400 


Gly Thr Leu Met Thr His Gly Ser Tyr Arg Val Arg Ile Ser Val Leu 
                405                 410                 415     


His Asp Gly Thr Leu Asn Phe Thr Asn Val Thr Val Gln Asp Thr Gly 
            420                 425                 430         


Gln Tyr Thr Cys Met Val Thr Asn Ser Ala Gly Asn Thr Thr Ala Ser 
        435                 440                 445             


Ala Thr Leu Asn Val Ser Ala Val Asp Pro Val Ala Ala Gly Gly Thr 
    450                 455                 460                 


Gly Ser Gly Gly Gly Gly Pro Gly Gly Ser Gly Gly Val Gly Gly Gly 
465                 470                 475                 480 


Ser Gly Gly Tyr Thr Tyr Phe Thr Thr Val Thr Val Glu Thr Leu Glu 
                485                 490                 495     


Thr Gln Pro Gly Glu Glu Ala Leu Gln Pro Arg Gly Thr Glu Lys Glu 
            500                 505                 510         


Pro Pro Gly Pro Thr Thr Asp Gly Val Trp Gly Gly Gly Arg Pro Gly 
        515                 520                 525             


Asp Ala Ala Gly Pro Ala Ser Ser Ser Thr Thr Ala Pro Ala Pro Arg 
    530                 535                 540                 


Ser Ser Arg Pro Thr Glu Lys Ala Phe Thr Val Pro Ile Thr Asp Val 
545                 550                 555                 560 


Thr Glu Asn Ala Leu Lys Asp Leu Asp Asp Val Met Lys Thr Thr Lys 
                565                 570                 575     


Ile Ile Ile Gly Cys Phe Val Ala Ile Thr Phe Met Ala Ala Val Met 
            580                 585                 590         


Leu Val Ala Phe Tyr Lys Leu Arg Lys Gln His Gln Leu His Lys His 
        595                 600                 605             


His Gly Pro Thr Arg Thr Val Glu Ile Ile Asn Val Glu Asp Glu Leu 
    610                 615                 620                 


Pro Ala Ala Ser Ala Val Ser Val Ala Ala Ala Ala Ala Val Ala Ser 
625                 630                 635                 640 


Gly Gly Gly Val Gly Gly Asp Ser His Leu Ala Leu Pro Ala Leu Glu 
                645                 650                 655     


Arg Asp His Leu Asn His His His Tyr Val Ala Ala Ala Phe Lys Ala 
            660                 665                 670         


His Tyr Ser Ser Asn Pro Ser Gly Gly Gly Cys Gly Gly Lys Gly Pro 
        675                 680                 685             


Pro Gly Leu Asn Ser Ile His Glu Pro Leu Leu Phe Lys Ser Gly Ser 
    690                 695                 700                 


Lys Glu Asn Val Gln Glu Thr Gln Ile 
705                 710             


<210>  1027
<211>  1037
<212>  PRT
<213>  Homo sapiens

<400>  1027

Met Ser Pro Pro Leu Cys Pro Leu Leu Leu Leu Ala Val Gly Leu Arg 
1               5                   10                  15      


Leu Ala Gly Thr Leu Asn Pro Ser Asp Pro Asn Thr Cys Ser Phe Trp 
            20                  25                  30          


Glu Ser Phe Thr Thr Thr Thr Lys Glu Ser His Ser Arg Pro Phe Ser 
        35                  40                  45              


Leu Leu Pro Ser Glu Pro Cys Glu Arg Pro Trp Glu Gly Pro His Thr 
    50                  55                  60                  


Cys Pro Gln Pro Thr Val Val Tyr Arg Thr Val Tyr Arg Gln Val Val 
65                  70                  75                  80  


Lys Thr Asp His Arg Gln Arg Leu Gln Cys Cys His Gly Phe Tyr Glu 
                85                  90                  95      


Ser Arg Gly Phe Cys Val Pro Leu Cys Ala Gln Glu Cys Val His Gly 
            100                 105                 110         


Arg Cys Val Ala Pro Asn Gln Cys Gln Cys Val Pro Gly Trp Arg Gly 
        115                 120                 125             


Asp Asp Cys Ser Ser Glu Cys Ala Pro Gly Met Trp Gly Pro Gln Cys 
    130                 135                 140                 


Asp Lys Pro Cys Ser Cys Gly Asn Asn Ser Ser Cys Asp Pro Lys Ser 
145                 150                 155                 160 


Gly Val Cys Ser Cys Pro Ser Gly Leu Gln Pro Pro Asn Cys Leu Gln 
                165                 170                 175     


Pro Cys Thr Pro Gly Tyr Tyr Gly Pro Ala Cys Gln Phe Arg Cys Gln 
            180                 185                 190         


Cys His Gly Ala Pro Cys Asp Pro Gln Thr Gly Ala Cys Phe Cys Pro 
        195                 200                 205             


Ala Glu Arg Thr Gly Pro Ser Cys Asp Val Ser Cys Ser Gln Gly Thr 
    210                 215                 220                 


Ser Gly Phe Phe Cys Pro Ser Thr His Ser Cys Gln Asn Gly Gly Val 
225                 230                 235                 240 


Phe Gln Thr Pro Gln Gly Ser Cys Ser Cys Pro Pro Gly Trp Met Gly 
                245                 250                 255     


Thr Ile Cys Ser Leu Pro Cys Pro Glu Gly Phe His Gly Pro Asn Cys 
            260                 265                 270         


Ser Gln Glu Cys Arg Cys His Asn Gly Gly Leu Cys Asp Arg Phe Thr 
        275                 280                 285             


Gly Gln Cys Arg Cys Ala Pro Gly Tyr Thr Gly Asp Arg Cys Arg Glu 
    290                 295                 300                 


Glu Cys Pro Val Gly Arg Phe Gly Gln Asp Cys Ala Glu Thr Cys Asp 
305                 310                 315                 320 


Cys Ala Pro Asp Ala Arg Cys Phe Pro Ala Asn Gly Ala Cys Leu Cys 
                325                 330                 335     


Glu His Gly Phe Thr Gly Asp Arg Cys Thr Asp Arg Leu Cys Pro Asp 
            340                 345                 350         


Gly Phe Tyr Gly Leu Ser Cys Gln Ala Pro Cys Thr Cys Asp Arg Glu 
        355                 360                 365             


His Ser Leu Ser Cys His Pro Met Asn Gly Glu Cys Ser Cys Leu Pro 
    370                 375                 380                 


Gly Trp Ala Gly Leu His Cys Asn Glu Ser Cys Pro Gln Asp Thr His 
385                 390                 395                 400 


Gly Pro Gly Cys Gln Glu His Cys Leu Cys Leu His Gly Gly Val Cys 
                405                 410                 415     


Gln Ala Thr Ser Gly Leu Cys Gln Cys Ala Pro Gly Tyr Thr Gly Pro 
            420                 425                 430         


His Cys Ala Ser Leu Cys Pro Pro Asp Thr Tyr Gly Val Asn Cys Ser 
        435                 440                 445             


Ala Arg Cys Ser Cys Glu Asn Ala Ile Ala Cys Ser Pro Ile Asp Gly 
    450                 455                 460                 


Glu Cys Val Cys Lys Glu Gly Trp Gln Arg Gly Asn Cys Ser Val Pro 
465                 470                 475                 480 


Cys Pro Pro Gly Thr Trp Gly Phe Ser Cys Asn Ala Ser Cys Gln Cys 
                485                 490                 495     


Ala His Glu Ala Val Cys Ser Pro Gln Thr Gly Ala Cys Thr Cys Thr 
            500                 505                 510         


Pro Gly Trp His Gly Ala His Cys Gln Leu Pro Cys Pro Lys Gly Gln 
        515                 520                 525             


Phe Gly Glu Gly Cys Ala Ser Arg Cys Asp Cys Asp His Ser Asp Gly 
    530                 535                 540                 


Cys Asp Pro Val His Gly Arg Cys Gln Cys Gln Ala Gly Trp Met Gly 
545                 550                 555                 560 


Ala Arg Cys His Leu Ser Cys Pro Glu Gly Leu Trp Gly Val Asn Cys 
                565                 570                 575     


Ser Asn Thr Cys Thr Cys Lys Asn Gly Gly Thr Cys Leu Pro Glu Asn 
            580                 585                 590         


Gly Asn Cys Val Cys Ala Pro Gly Phe Arg Gly Pro Ser Cys Gln Arg 
        595                 600                 605             


Ser Cys Gln Pro Gly Arg Tyr Gly Lys Arg Cys Val Pro Cys Lys Cys 
    610                 615                 620                 


Ala Asn His Ser Phe Cys His Pro Ser Asn Gly Thr Cys Tyr Cys Leu 
625                 630                 635                 640 


Ala Gly Trp Thr Gly Pro Asp Cys Ser Gln Pro Cys Pro Pro Gly His 
                645                 650                 655     


Trp Gly Glu Asn Cys Ala Gln Thr Cys Gln Cys His His Gly Gly Thr 
            660                 665                 670         


Cys His Pro Gln Asp Gly Ser Cys Ile Cys Pro Leu Gly Trp Thr Gly 
        675                 680                 685             


His His Cys Leu Glu Gly Cys Pro Leu Gly Thr Phe Gly Ala Asn Cys 
    690                 695                 700                 


Ser Gln Pro Cys Gln Cys Gly Pro Gly Glu Lys Cys His Pro Glu Thr 
705                 710                 715                 720 


Gly Ala Cys Val Cys Pro Pro Gly His Ser Gly Ala Pro Cys Arg Ile 
                725                 730                 735     


Gly Ile Gln Glu Pro Phe Thr Val Met Pro Thr Thr Pro Val Ala Tyr 
            740                 745                 750         


Asn Ser Leu Gly Ala Val Ile Gly Ile Ala Val Leu Gly Ser Leu Val 
        755                 760                 765             


Val Ala Leu Val Ala Leu Phe Ile Gly Tyr Arg His Trp Gln Lys Gly 
    770                 775                 780                 


Lys Glu His His His Leu Ala Val Ala Tyr Ser Ser Gly Arg Leu Asp 
785                 790                 795                 800 


Gly Ser Glu Tyr Val Met Pro Asp Val Pro Pro Ser Tyr Ser His Tyr 
                805                 810                 815     


Tyr Ser Asn Pro Ser Tyr His Thr Leu Ser Gln Cys Ser Pro Asn Pro 
            820                 825                 830         


Pro Pro Pro Asn Lys Val Pro Gly Pro Leu Phe Ala Ser Leu Gln Asn 
        835                 840                 845             


Pro Glu Arg Pro Gly Gly Ala Gln Gly His Asp Asn His Thr Thr Leu 
    850                 855                 860                 


Pro Ala Asp Trp Lys His Arg Arg Glu Pro Pro Pro Gly Pro Leu Asp 
865                 870                 875                 880 


Arg Gly Ser Ser Arg Leu Asp Arg Ser Tyr Ser Tyr Ser Tyr Ser Asn 
                885                 890                 895     


Gly Pro Gly Pro Phe Tyr Asn Lys Gly Leu Ile Ser Glu Glu Glu Leu 
            900                 905                 910         


Gly Ala Ser Val Ala Ser Leu Ser Ser Glu Asn Pro Tyr Ala Thr Ile 
        915                 920                 925             


Arg Asp Leu Pro Ser Leu Pro Gly Gly Pro Arg Glu Ser Ser Tyr Met 
    930                 935                 940                 


Glu Met Lys Gly Pro Pro Ser Gly Ser Pro Pro Arg Gln Pro Pro Gln 
945                 950                 955                 960 


Phe Trp Asp Ser Gln Arg Arg Arg Gln Pro Gln Pro Gln Arg Asp Ser 
                965                 970                 975     


Gly Thr Tyr Glu Gln Pro Ser Pro Leu Ile His Asp Arg Asp Ser Val 
            980                 985                 990         


Gly Ser Gln Pro Pro Leu Pro Pro  Gly Leu Pro Pro Gly  His Tyr Asp 
        995                 1000                 1005             


Ser Pro  Lys Asn Ser His Ile  Pro Gly His Tyr Asp  Leu Pro Pro 
    1010                 1015                 1020             


Val Arg  His Pro Pro Ser Pro  Pro Leu Arg Arg Gln  Asp Arg 
    1025                 1030                 1035         


<210>  1028
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  1028

Met Glu His Leu Glu Arg Cys Glu Trp Leu Leu Arg Gly Thr Leu Val 
1               5                   10                  15      


Arg Ala Ala Val Arg Arg Tyr Leu Pro Trp Ala Leu Val Ala Ser Met 
            20                  25                  30          


Leu Ala Gly Ser Leu Leu Lys Glu Leu Ser Pro Leu Pro Glu Ser Tyr 
        35                  40                  45              


Leu Ser Asn Lys Arg Asn Val Leu Asn Val Tyr Phe Val Lys Val Ala 
    50                  55                  60                  


Trp Ala Trp Thr Phe Cys Leu Leu Leu Pro Phe Ile Ala Leu Thr Asn 
65                  70                  75                  80  


Tyr His Leu Thr Gly Lys Ala Gly Leu Val Leu Arg Arg Leu Ser Thr 
                85                  90                  95      


Leu Leu Val Gly Thr Ala Ile Trp Tyr Ile Cys Thr Ser Ile Phe Ser 
            100                 105                 110         


Asn Ile Glu His Tyr Thr Gly Ser Cys Tyr Gln Ser Pro Ala Leu Glu 
        115                 120                 125             


Gly Val Arg Lys Glu His Gln Ser Lys Gln Gln Cys His Gln Glu Gly 
    130                 135                 140                 


Gly Phe Trp His Gly Phe Asp Ile Ser Gly His Ser Phe Leu Leu Thr 
145                 150                 155                 160 


Phe Cys Ala Leu Met Ile Val Glu Glu Met Ser Val Leu His Glu Val 
                165                 170                 175     


Lys Thr Asp Arg Ser His Cys Leu His Thr Ala Ile Thr Thr Leu Val 
            180                 185                 190         


Val Ala Leu Gly Ile Leu Thr Phe Ile Trp Val Leu Met Phe Leu Cys 
        195                 200                 205             


Thr Ala Val Tyr Phe His Asn Leu Ser Gln Lys Val Phe Gly Thr Leu 
    210                 215                 220                 


Phe Gly Leu Leu Ser Trp Tyr Gly Thr Tyr Gly Phe Trp Tyr Pro Lys 
225                 230                 235                 240 


Ala Phe Ser Pro Gly Leu Pro Pro Gln Ser Cys Ser Leu Asn Leu Lys 
                245                 250                 255     


Gln Asp Ser Tyr Lys Lys 
            260         


<210>  1029
<211>  2699
<212>  PRT
<213>  Homo sapiens

<400>  1029

Met Asp Val Lys Glu Arg Arg Pro Tyr Cys Ser Leu Thr Lys Ser Arg 
1               5                   10                  15      


Arg Glu Lys Glu Arg Arg Tyr Thr Asn Ser Ser Ala Asp Asn Glu Glu 
            20                  25                  30          


Cys Arg Val Pro Thr Gln Lys Ser Tyr Ser Ser Ser Glu Thr Leu Lys 
        35                  40                  45              


Ala Phe Asp His Asp Ser Ser Arg Leu Leu Tyr Gly Asn Arg Val Lys 
    50                  55                  60                  


Asp Leu Val His Arg Glu Ala Asp Glu Phe Thr Arg Gln Gly Gln Asn 
65                  70                  75                  80  


Phe Thr Leu Arg Gln Leu Gly Val Cys Glu Pro Ala Thr Arg Arg Gly 
                85                  90                  95      


Leu Ala Phe Cys Ala Glu Met Gly Leu Pro His Arg Gly Tyr Ser Ile 
            100                 105                 110         


Ser Ala Gly Ser Asp Ala Asp Thr Glu Asn Glu Ala Val Met Ser Pro 
        115                 120                 125             


Glu His Ala Met Arg Leu Trp Gly Arg Gly Val Lys Ser Gly Arg Ser 
    130                 135                 140                 


Ser Cys Leu Ser Ser Arg Ser Asn Ser Ala Leu Thr Leu Thr Asp Thr 
145                 150                 155                 160 


Glu His Glu Asn Lys Ser Asp Ser Glu Asn Glu Gln Pro Ala Ser Asn 
                165                 170                 175     


Gln Gly Gln Ser Thr Leu Gln Pro Leu Pro Pro Ser His Lys Gln His 
            180                 185                 190         


Ser Ala Gln His His Pro Ser Ile Thr Ser Leu Asn Arg Asn Ser Leu 
        195                 200                 205             


Thr Asn Arg Arg Asn Gln Ser Pro Ala Pro Pro Ala Ala Leu Pro Ala 
    210                 215                 220                 


Glu Leu Gln Thr Thr Pro Glu Ser Val Gln Leu Gln Asp Ser Trp Val 
225                 230                 235                 240 


Leu Gly Ser Asn Val Pro Leu Glu Ser Arg His Phe Leu Phe Lys Thr 
                245                 250                 255     


Gly Thr Gly Thr Thr Pro Leu Phe Ser Thr Ala Thr Pro Gly Tyr Thr 
            260                 265                 270         


Met Ala Ser Gly Ser Val Tyr Ser Pro Pro Thr Arg Pro Leu Pro Arg 
        275                 280                 285             


Asn Thr Leu Ser Arg Ser Ala Phe Lys Phe Lys Lys Ser Ser Lys Tyr 
    290                 295                 300                 


Cys Ser Trp Lys Cys Thr Ala Leu Cys Ala Val Gly Val Ser Val Leu 
305                 310                 315                 320 


Leu Ala Ile Leu Leu Ser Tyr Phe Ile Ala Met His Leu Phe Gly Leu 
                325                 330                 335     


Asn Trp Gln Leu Gln Gln Thr Glu Asn Asp Thr Phe Glu Asn Gly Lys 
            340                 345                 350         


Val Asn Ser Asp Thr Met Pro Thr Asn Thr Val Ser Leu Pro Ser Gly 
        355                 360                 365             


Asp Asn Gly Lys Leu Gly Gly Phe Thr Gln Glu Asn Asn Thr Ile Asp 
    370                 375                 380                 


Ser Gly Glu Leu Asp Ile Gly Arg Arg Ala Ile Gln Glu Ile Pro Pro 
385                 390                 395                 400 


Gly Ile Phe Trp Arg Ser Gln Leu Phe Ile Asp Gln Pro Gln Phe Leu 
                405                 410                 415     


Lys Phe Asn Ile Ser Leu Gln Lys Asp Ala Leu Ile Gly Val Tyr Gly 
            420                 425                 430         


Arg Lys Gly Leu Pro Pro Ser His Thr Gln Tyr Asp Phe Val Glu Leu 
        435                 440                 445             


Leu Asp Gly Ser Arg Leu Ile Ala Arg Glu Gln Arg Ser Leu Leu Glu 
    450                 455                 460                 


Thr Glu Arg Ala Gly Arg Gln Ala Arg Ser Val Ser Leu His Glu Ala 
465                 470                 475                 480 


Gly Phe Ile Gln Tyr Leu Asp Ser Gly Ile Trp His Leu Ala Phe Tyr 
                485                 490                 495     


Asn Asp Gly Lys Asn Ala Glu Gln Val Ser Phe Asn Thr Ile Val Ile 
            500                 505                 510         


Glu Ser Val Val Glu Cys Pro Arg Asn Cys His Gly Asn Gly Glu Cys 
        515                 520                 525             


Val Ser Gly Thr Cys His Cys Phe Pro Gly Phe Leu Gly Pro Asp Cys 
    530                 535                 540                 


Ser Arg Ala Ala Cys Pro Val Leu Cys Ser Gly Asn Gly Gln Tyr Ser 
545                 550                 555                 560 


Lys Gly Arg Cys Leu Cys Phe Ser Gly Trp Lys Gly Thr Glu Cys Asp 
                565                 570                 575     


Val Pro Thr Thr Gln Cys Ile Asp Pro Gln Cys Gly Gly Arg Gly Ile 
            580                 585                 590         


Cys Ile Met Gly Ser Cys Ala Cys Asn Ser Gly Tyr Lys Gly Glu Ser 
        595                 600                 605             


Cys Glu Glu Ala Asp Cys Ile Asp Pro Gly Cys Ser Asn His Gly Val 
    610                 615                 620                 


Cys Ile His Gly Glu Cys His Cys Ser Pro Gly Trp Gly Gly Ser Asn 
625                 630                 635                 640 


Cys Glu Ile Leu Lys Thr Met Cys Pro Asp Gln Cys Ser Gly His Gly 
                645                 650                 655     


Thr Tyr Leu Gln Glu Ser Gly Ser Cys Thr Cys Asp Pro Asn Trp Thr 
            660                 665                 670         


Gly Pro Asp Cys Ser Asn Glu Ile Cys Ser Val Asp Cys Gly Ser His 
        675                 680                 685             


Gly Val Cys Met Gly Gly Thr Cys Arg Cys Glu Glu Gly Trp Thr Gly 
    690                 695                 700                 


Pro Ala Cys Asn Gln Arg Ala Cys His Pro Arg Cys Ala Glu His Gly 
705                 710                 715                 720 


Thr Cys Lys Asp Gly Lys Cys Glu Cys Ser Gln Gly Trp Asn Gly Glu 
                725                 730                 735     


His Cys Thr Ile Glu Gly Cys Pro Gly Leu Cys Asn Ser Asn Gly Arg 
            740                 745                 750         


Cys Thr Leu Asp Gln Asn Gly Trp His Cys Val Cys Gln Pro Gly Trp 
        755                 760                 765             


Arg Gly Ala Gly Cys Asp Val Ala Met Glu Thr Leu Cys Thr Asp Ser 
    770                 775                 780                 


Lys Asp Asn Glu Gly Asp Gly Leu Ile Asp Cys Met Asp Pro Asp Cys 
785                 790                 795                 800 


Cys Leu Gln Ser Ser Cys Gln Asn Gln Pro Tyr Cys Arg Gly Leu Pro 
                805                 810                 815     


Asp Pro Gln Asp Ile Ile Ser Gln Ser Leu Gln Ser Pro Ser Gln Gln 
            820                 825                 830         


Ala Ala Lys Ser Phe Tyr Asp Arg Ile Ser Phe Leu Ile Gly Ser Asp 
        835                 840                 845             


Ser Thr His Val Ile Pro Gly Glu Ser Pro Phe Asn Lys Ser Leu Ala 
    850                 855                 860                 


Ser Val Ile Arg Gly Gln Val Leu Thr Ala Asp Gly Thr Pro Leu Ile 
865                 870                 875                 880 


Gly Val Asn Val Ser Phe Phe His Tyr Pro Glu Tyr Gly Tyr Thr Ile 
                885                 890                 895     


Thr Arg Gln Asp Gly Met Phe Asp Leu Val Ala Asn Gly Gly Ala Ser 
            900                 905                 910         


Leu Thr Leu Val Phe Glu Arg Ser Pro Phe Leu Thr Gln Tyr His Thr 
        915                 920                 925             


Val Trp Ile Pro Trp Asn Val Phe Tyr Val Met Asp Thr Leu Val Met 
    930                 935                 940                 


Lys Lys Glu Glu Asn Asp Ile Pro Ser Cys Asp Leu Ser Gly Phe Val 
945                 950                 955                 960 


Arg Pro Asn Pro Ile Ile Val Ser Ser Pro Leu Ser Thr Phe Phe Arg 
                965                 970                 975     


Ser Ser Pro Glu Asp Ser Pro Ile Ile Pro Glu Thr Gln Val Leu His 
            980                 985                 990         


Glu Glu Thr Thr Ile Pro Gly Thr  Asp Leu Lys Leu Ser  Tyr Leu Ser 
        995                 1000                 1005             


Ser Arg  Ala Ala Gly Tyr Lys  Ser Val Leu Lys Ile  Thr Met Thr 
    1010                 1015                 1020             


Gln Ser  Ile Ile Pro Phe Asn  Leu Met Lys Val His  Leu Met Val 
    1025                 1030                 1035             


Ala Val  Val Gly Arg Leu Phe  Gln Lys Trp Phe Pro  Ala Ser Pro 
    1040                 1045                 1050             


Asn Leu  Ala Tyr Thr Phe Ile  Trp Asp Lys Thr Asp  Ala Tyr Asn 
    1055                 1060                 1065             


Gln Lys  Val Tyr Gly Leu Ser  Glu Ala Val Val Ser  Val Gly Tyr 
    1070                 1075                 1080             


Glu Tyr  Glu Ser Cys Leu Asp  Leu Thr Leu Trp Glu  Lys Arg Thr 
    1085                 1090                 1095             


Ala Ile  Leu Gln Gly Tyr Glu  Leu Asp Ala Ser Asn  Met Gly Gly 
    1100                 1105                 1110             


Trp Thr  Leu Asp Lys His His  Val Leu Asp Val Gln  Asn Gly Ile 
    1115                 1120                 1125             


Leu Tyr  Lys Gly Asn Gly Glu  Asn Gln Phe Ile Ser  Gln Gln Pro 
    1130                 1135                 1140             


Pro Val  Val Ser Ser Ile Met  Gly Asn Gly Arg Arg  Arg Ser Ile 
    1145                 1150                 1155             


Ser Cys  Pro Ser Cys Asn Gly  Gln Ala Asp Gly Asn  Lys Leu Leu 
    1160                 1165                 1170             


Ala Pro  Val Ala Leu Ala Cys  Gly Ile Asp Gly Ser  Leu Tyr Val 
    1175                 1180                 1185             


Gly Asp  Phe Asn Tyr Val Arg  Arg Ile Phe Pro Ser  Gly Asn Val 
    1190                 1195                 1200             


Thr Ser  Val Leu Glu Leu Ser  Ser Asn Pro Ala His  Arg Tyr Tyr 
    1205                 1210                 1215             


Leu Ala  Thr Asp Pro Val Thr  Gly Asp Leu Tyr Val  Ser Asp Thr 
    1220                 1225                 1230             


Asn Thr  Arg Arg Ile Tyr Arg  Pro Lys Ser Leu Thr  Gly Ala Lys 
    1235                 1240                 1245             


Asp Leu  Thr Lys Asn Ala Glu  Val Val Ala Gly Thr  Gly Glu Gln 
    1250                 1255                 1260             


Cys Leu  Pro Phe Asp Glu Ala  Arg Cys Gly Asp Gly  Gly Lys Ala 
    1265                 1270                 1275             


Val Glu  Ala Thr Leu Met Ser  Pro Lys Gly Met Ala  Val Asp Lys 
    1280                 1285                 1290             


Asn Gly  Leu Ile Tyr Phe Val  Asp Gly Thr Met Ile  Arg Lys Val 
    1295                 1300                 1305             


Asp Gln  Asn Gly Ile Ile Ser  Thr Leu Leu Gly Ser  Asn Asp Leu 
    1310                 1315                 1320             


Thr Ser  Ala Arg Pro Leu Thr  Cys Asp Thr Ser Met  His Ile Ser 
    1325                 1330                 1335             


Gln Val  Arg Leu Glu Trp Pro  Thr Asp Leu Ala Ile  Asn Pro Met 
    1340                 1345                 1350             


Asp Asn  Ser Ile Tyr Val Leu  Asp Asn Asn Val Val  Leu Gln Ile 
    1355                 1360                 1365             


Thr Glu  Asn Arg Gln Val Arg  Ile Ala Ala Gly Arg  Pro Met His 
    1370                 1375                 1380             


Cys Gln  Val Pro Gly Val Glu  Tyr Pro Val Gly Lys  His Ala Val 
    1385                 1390                 1395             


Gln Thr  Thr Leu Glu Ser Ala  Thr Ala Ile Ala Val  Ser Tyr Ser 
    1400                 1405                 1410             


Gly Val  Leu Tyr Ile Thr Glu  Thr Asp Glu Lys Lys  Ile Asn Arg 
    1415                 1420                 1425             


Ile Arg  Gln Val Thr Thr Asp  Gly Glu Ile Ser Leu  Val Ala Gly 
    1430                 1435                 1440             


Ile Pro  Ser Glu Cys Asp Cys  Lys Asn Asp Ala Asn  Cys Asp Cys 
    1445                 1450                 1455             


Tyr Gln  Ser Gly Asp Gly Tyr  Ala Lys Asp Ala Lys  Leu Ser Ala 
    1460                 1465                 1470             


Pro Ser  Ser Leu Ala Ala Ser  Pro Asp Gly Thr Leu  Tyr Ile Ala 
    1475                 1480                 1485             


Asp Leu  Gly Asn Ile Arg Ile  Arg Ala Val Ser Lys  Asn Lys Pro 
    1490                 1495                 1500             


Leu Leu  Asn Ser Met Asn Phe  Tyr Glu Val Ala Ser  Pro Thr Asp 
    1505                 1510                 1515             


Gln Glu  Leu Tyr Ile Phe Asp  Ile Asn Gly Thr His  Gln Tyr Thr 
    1520                 1525                 1530             


Val Ser  Leu Val Thr Gly Asp  Tyr Leu Tyr Asn Phe  Ser Tyr Ser 
    1535                 1540                 1545             


Asn Asp  Asn Asp Ile Thr Ala  Val Thr Asp Ser Asn  Gly Asn Thr 
    1550                 1555                 1560             


Leu Arg  Ile Arg Arg Asp Pro  Asn Arg Met Pro Val  Arg Val Val 
    1565                 1570                 1575             


Ser Pro  Asp Asn Gln Val Ile  Trp Leu Thr Ile Gly  Thr Asn Gly 
    1580                 1585                 1590             


Cys Leu  Lys Ser Met Thr Ala  Gln Gly Leu Glu Leu  Val Leu Phe 
    1595                 1600                 1605             


Thr Tyr  His Gly Asn Ser Gly  Leu Leu Ala Thr Lys  Ser Asp Glu 
    1610                 1615                 1620             


Thr Gly  Trp Thr Thr Phe Phe  Asp Tyr Asp Ser Glu  Gly Arg Leu 
    1625                 1630                 1635             


Thr Asn  Val Thr Phe Pro Thr  Gly Val Val Thr Asn  Leu His Gly 
    1640                 1645                 1650             


Asp Met  Asp Lys Ala Ile Thr  Val Asp Ile Glu Ser  Ser Ser Arg 
    1655                 1660                 1665             


Glu Glu  Asp Val Ser Ile Thr  Ser Asn Leu Ser Ser  Ile Asp Ser 
    1670                 1675                 1680             


Phe Tyr  Thr Met Val Gln Asp  Gln Leu Arg Asn Ser  Tyr Gln Ile 
    1685                 1690                 1695             


Gly Tyr  Asp Gly Ser Leu Arg  Ile Ile Tyr Ala Ser  Gly Leu Asp 
    1700                 1705                 1710             


Ser His  Tyr Gln Thr Glu Pro  His Val Leu Ala Gly  Thr Ala Asn 
    1715                 1720                 1725             


Pro Thr  Val Ala Lys Arg Asn  Met Thr Leu Pro Gly  Glu Asn Gly 
    1730                 1735                 1740             


Gln Asn  Leu Val Glu Trp Arg  Phe Arg Lys Glu Gln  Ala Gln Gly 
    1745                 1750                 1755             


Lys Val  Asn Val Phe Gly Arg  Lys Leu Arg Val Asn  Gly Arg Asn 
    1760                 1765                 1770             


Leu Leu  Ser Val Asp Phe Asp  Arg Thr Thr Lys Thr  Glu Lys Ile 
    1775                 1780                 1785             


Tyr Asp  Asp His Arg Lys Phe  Leu Leu Arg Ile Ala  Tyr Asp Thr 
    1790                 1795                 1800             


Ser Gly  His Pro Thr Leu Trp  Leu Pro Ser Ser Lys  Leu Met Ala 
    1805                 1810                 1815             


Val Asn  Val Thr Tyr Ser Ser  Thr Gly Gln Ile Ala  Ser Ile Gln 
    1820                 1825                 1830             


Arg Gly  Thr Thr Ser Glu Lys  Val Asp Tyr Asp Gly  Gln Gly Arg 
    1835                 1840                 1845             


Ile Val  Ser Arg Val Phe Ala  Asp Gly Lys Thr Trp  Ser Tyr Thr 
    1850                 1855                 1860             


Tyr Leu  Glu Lys Ser Met Val  Leu Leu Leu His Ser  Gln Arg Gln 
    1865                 1870                 1875             


Tyr Ile  Phe Glu Tyr Asp Met  Trp Asp Arg Leu Ser  Ala Ile Thr 
    1880                 1885                 1890             


Met Pro  Ser Val Ala Arg His  Thr Met Gln Thr Ile  Arg Ser Ile 
    1895                 1900                 1905             


Gly Tyr  Tyr Arg Asn Ile Tyr  Asn Pro Pro Glu Ser  Asn Ala Ser 
    1910                 1915                 1920             


Ile Ile  Thr Asp Tyr Asn Glu  Glu Gly Leu Leu Leu  Gln Thr Ala 
    1925                 1930                 1935             


Phe Leu  Gly Thr Ser Arg Arg  Val Leu Phe Lys Tyr  Arg Arg Gln 
    1940                 1945                 1950             


Thr Arg  Leu Ser Glu Ile Leu  Tyr Asp Ser Thr Arg  Val Ser Phe 
    1955                 1960                 1965             


Thr Tyr  Asp Glu Thr Ala Gly  Val Leu Lys Thr Val  Asn Leu Gln 
    1970                 1975                 1980             


Ser Asp  Gly Phe Ile Cys Thr  Ile Arg Tyr Arg Gln  Ile Gly Pro 
    1985                 1990                 1995             


Leu Ile  Asp Arg Gln Ile Phe  Arg Phe Ser Glu Asp  Gly Met Val 
    2000                 2005                 2010             


Asn Ala  Arg Phe Asp Tyr Ser  Tyr Asp Asn Ser Phe  Arg Val Thr 
    2015                 2020                 2025             


Ser Met  Gln Gly Val Ile Asn  Glu Thr Pro Leu Pro  Ile Asp Leu 
    2030                 2035                 2040             


Tyr Gln  Phe Asp Asp Ile Ser  Gly Lys Val Glu Gln  Phe Gly Lys 
    2045                 2050                 2055             


Phe Gly  Val Ile Tyr Tyr Asp  Ile Asn Gln Ile Ile  Ser Thr Ala 
    2060                 2065                 2070             


Val Met  Thr Tyr Thr Lys His  Phe Asp Ala His Gly  Arg Ile Lys 
    2075                 2080                 2085             


Glu Ile  Gln Tyr Glu Ile Phe  Arg Ser Leu Met Tyr  Trp Ile Thr 
    2090                 2095                 2100             


Ile Gln  Tyr Asp Asn Met Gly  Arg Val Thr Lys Arg  Glu Ile Lys 
    2105                 2110                 2115             


Ile Gly  Pro Phe Ala Asn Thr  Thr Lys Tyr Ala Tyr  Glu Tyr Asp 
    2120                 2125                 2130             


Val Asp  Gly Gln Leu Gln Thr  Val Tyr Leu Asn Glu  Lys Ile Met 
    2135                 2140                 2145             


Trp Arg  Tyr Asn Tyr Asp Leu  Asn Gly Asn Leu His  Leu Leu Asn 
    2150                 2155                 2160             


Pro Ser  Asn Ser Ala Arg Leu  Thr Pro Leu Arg Tyr  Asp Leu Arg 
    2165                 2170                 2175             


Asp Arg  Ile Thr Arg Leu Gly  Asp Val Gln Tyr Arg  Leu Asp Glu 
    2180                 2185                 2190             


Asp Gly  Phe Leu Arg Gln Arg  Gly Thr Glu Ile Phe  Glu Tyr Ser 
    2195                 2200                 2205             


Ser Lys  Gly Leu Leu Thr Arg  Val Tyr Ser Lys Gly  Ser Gly Trp 
    2210                 2215                 2220             


Thr Val  Ile Tyr Arg Tyr Asp  Gly Leu Gly Arg Arg  Val Ser Ser 
    2225                 2230                 2235             


Lys Thr  Ser Leu Gly Gln His  Leu Gln Phe Phe Tyr  Ala Asp Leu 
    2240                 2245                 2250             


Thr Tyr  Pro Thr Arg Ile Thr  His Val Tyr Asn His  Ser Ser Ser 
    2255                 2260                 2265             


Glu Ile  Thr Ser Leu Tyr Tyr  Asp Leu Gln Gly His  Leu Phe Ala 
    2270                 2275                 2280             


Met Glu  Ile Ser Ser Gly Asp  Glu Phe Tyr Ile Ala  Ser Asp Asn 
    2285                 2290                 2295             


Thr Gly  Thr Pro Leu Ala Val  Phe Ser Ser Asn Gly  Leu Met Leu 
    2300                 2305                 2310             


Lys Gln  Ile Gln Tyr Thr Ala  Tyr Gly Glu Ile Tyr  Phe Asp Ser 
    2315                 2320                 2325             


Asn Ile  Asp Phe Gln Leu Val  Ile Gly Phe His Gly  Gly Leu Tyr 
    2330                 2335                 2340             


Asp Pro  Leu Thr Lys Leu Ile  His Phe Gly Glu Arg  Asp Tyr Asp 
    2345                 2350                 2355             


Ile Leu  Ala Gly Arg Trp Thr  Thr Pro Asp Ile Glu  Ile Trp Lys 
    2360                 2365                 2370             


Arg Ile  Gly Lys Asp Pro Ala  Pro Phe Asn Leu Tyr  Met Phe Arg 
    2375                 2380                 2385             


Asn Asn  Asn Pro Ala Ser Lys  Ile His Asp Val Lys  Asp Tyr Ile 
    2390                 2395                 2400             


Thr Asp  Val Asn Ser Trp Leu  Val Thr Phe Gly Phe  His Leu His 
    2405                 2410                 2415             


Asn Ala  Ile Pro Gly Phe Pro  Val Pro Lys Phe Asp  Leu Thr Glu 
    2420                 2425                 2430             


Pro Ser  Tyr Glu Leu Val Lys  Ser Gln Gln Trp Asp  Asp Ile Pro 
    2435                 2440                 2445             


Pro Ile  Phe Gly Val Gln Gln  Gln Val Ala Arg Gln  Ala Lys Ala 
    2450                 2455                 2460             


Phe Leu  Ser Leu Gly Lys Met  Ala Glu Val Gln Val  Ser Arg Arg 
    2465                 2470                 2475             


Arg Ala  Gly Gly Ala Gln Ser  Trp Leu Trp Phe Ala  Thr Val Lys 
    2480                 2485                 2490             


Ser Leu  Ile Gly Lys Gly Val  Met Leu Ala Val Ser  Gln Gly Arg 
    2495                 2500                 2505             


Val Gln  Thr Asn Val Leu Asn  Ile Ala Asn Glu Asp  Cys Ile Lys 
    2510                 2515                 2520             


Val Ala  Ala Val Leu Asn Asn  Ala Phe Tyr Leu Glu  Asn Leu His 
    2525                 2530                 2535             


Phe Thr  Ile Glu Gly Lys Asp  Thr His Tyr Phe Ile  Lys Thr Thr 
    2540                 2545                 2550             


Thr Pro  Glu Ser Asp Leu Gly  Thr Leu Arg Leu Thr  Ser Gly Arg 
    2555                 2560                 2565             


Lys Ala  Leu Glu Asn Gly Ile  Asn Val Thr Val Ser  Gln Ser Thr 
    2570                 2575                 2580             


Thr Val  Val Asn Gly Arg Thr  Arg Arg Phe Ala Asp  Val Glu Met 
    2585                 2590                 2595             


Gln Phe  Gly Ala Leu Ala Leu  His Val Arg Tyr Gly  Met Thr Leu 
    2600                 2605                 2610             


Asp Glu  Glu Lys Ala Arg Ile  Leu Glu Gln Ala Arg  Gln Arg Ala 
    2615                 2620                 2625             


Leu Ala  Arg Ala Trp Ala Arg  Glu Gln Gln Arg Val  Arg Asp Gly 
    2630                 2635                 2640             


Glu Glu  Gly Ala Arg Leu Trp  Thr Glu Gly Glu Lys  Arg Gln Leu 
    2645                 2650                 2655             


Leu Ser  Ala Gly Lys Val Gln  Gly Tyr Asp Gly Tyr  Tyr Val Leu 
    2660                 2665                 2670             


Ser Val  Glu Gln Tyr Pro Glu  Leu Ala Asp Ser Ala  Asn Asn Ile 
    2675                 2680                 2685             


Gln Phe  Leu Arg Gln Ser Glu  Ile Gly Arg Arg 
    2690                 2695                 


<210>  1030
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  1030

Met Ala Ala Glu Pro Gln Pro Ser Ser Leu Ser Tyr Arg Thr Thr Gly 
1               5                   10                  15      


Ser Thr Tyr Leu His Pro Leu Ser Glu Leu Leu Gly Ile Pro Leu Asp 
            20                  25                  30          


Gln Val Asn Phe Val Val Cys Gln Leu Val Ala Leu Phe Ala Ala Phe 
        35                  40                  45              


Trp Phe Arg Ile Tyr Leu Arg Pro Gly Thr Thr Ser Ser Asp Val Arg 
    50                  55                  60                  


His Ala Val Ala Thr Ile Phe Gly Ile Tyr Phe Val Ile Phe Cys Phe 
65                  70                  75                  80  


Gly Trp Tyr Ser Val His Leu Phe Val Leu Val Leu Met Cys Tyr Ala 
                85                  90                  95      


Ile Met Val Thr Ala Ser Val Ser Asn Ile His Arg Tyr Ser Phe Phe 
            100                 105                 110         


Val Ala Met Gly Tyr Leu Thr Ile Cys His Ile Ser Arg Ile Tyr Ile 
        115                 120                 125             


Phe His Tyr Gly Ile Leu Thr Thr Asp Phe Ser Gly Pro Leu Met Ile 
    130                 135                 140                 


Val Thr Gln Lys Ile Thr Thr Leu Ala Phe Gln Val His Asp Gly Leu 
145                 150                 155                 160 


Gly Arg Arg Ala Glu Asp Leu Ser Ala Glu Gln His Arg Leu Ala Ile 
                165                 170                 175     


Lys Val Lys Pro Ser Phe Leu Glu Tyr Leu Ser Tyr Leu Leu Asn Phe 
            180                 185                 190         


Met Ser Val Ile Ala Gly Pro Cys Asn Asn Phe Lys Asp Tyr Ile Ala 
        195                 200                 205             


Phe Ile Glu Gly Lys His Ile His Met Lys Leu Leu Glu Val Asn Trp 
    210                 215                 220                 


Lys Arg Lys Gly Phe His Ser Leu Pro Glu Pro Ser Pro Thr Gly Ala 
225                 230                 235                 240 


Val Ile His Lys Leu Gly Ile Thr Leu Val Ser Leu Leu Leu Phe Leu 
                245                 250                 255     


Thr Leu Thr Lys Thr Phe Pro Val Thr Cys Leu Val Asp Asp Trp Phe 
            260                 265                 270         


Val His Lys Ala Ser Phe Pro Ala Arg Leu Cys Tyr Leu Tyr Val Val 
        275                 280                 285             


Met Gln Ala Ser Lys Pro Lys Tyr Tyr Phe Ala Trp Thr Leu Ala Asp 
    290                 295                 300                 


Ala Val Asn Asn Ala Ala Gly Phe Gly Phe Ser Gly Val Asp Lys Asn 
305                 310                 315                 320 


Gly Asn Phe Cys Trp Asp Leu Leu Ser Asn Leu Asn Ile Trp Lys Ile 
                325                 330                 335     


Glu Thr Ala Thr Ser Phe Lys Met Tyr Leu Glu Asn Trp Asn Ile Gln 
            340                 345                 350         


Thr Ala Thr Trp Leu Lys Cys Val Cys Tyr Gln Arg Val Pro Trp Tyr 
        355                 360                 365             


Pro Thr Val Leu Thr Phe Ile Leu Ser Ala Leu Trp His Gly Val Tyr 
    370                 375                 380                 


Pro Gly Tyr Tyr Phe Thr Phe Leu Thr Gly Ile Leu Val Thr Leu Ala 
385                 390                 395                 400 


Ala Arg Ala Val Arg Asn Asn Tyr Arg His Tyr Phe Leu Ser Ser Arg 
                405                 410                 415     


Ala Leu Lys Ala Val Tyr Asp Ala Gly Thr Trp Ala Val Thr Gln Leu 
            420                 425                 430         


Ala Val Ser Tyr Thr Val Ala Pro Phe Val Met Leu Ala Val Glu Pro 
        435                 440                 445             


Thr Ile Ser Leu Tyr Lys Ser Met Tyr Phe Tyr Leu His Ile Ile Ser 
    450                 455                 460                 


Leu Leu Ile Ile Leu Phe Leu Pro Met Lys Pro Gln Ala His Thr Gln 
465                 470                 475                 480 


Arg Arg Pro Gln Thr Leu Asn Ser Ile Asn Lys Arg Lys Thr Asp 
                485                 490                 495 


<210>  1031
<211>  602
<212>  PRT
<213>  Homo sapiens

<400>  1031

Met Asn Gly Gly Ala Glu Arg Ala Met Arg Ser Leu Pro Ser Leu Gly 
1               5                   10                  15      


Gly Leu Ala Leu Leu Cys Cys Ala Ala Ala Ala Ala Ala Ala Ala Val 
            20                  25                  30          


Ala Ser Ala Ala Ser Ala Gly Asn Val Thr Gly Gly Gly Gly Ala Ala 
        35                  40                  45              


Gly Gln Val Asp Ala Ser Pro Gly Pro Gly Leu Arg Gly Glu Pro Ser 
    50                  55                  60                  


His Pro Phe Pro Arg Ala Thr Ala Pro Thr Ala Gln Ala Pro Arg Thr 
65                  70                  75                  80  


Gly Pro Pro Arg Ala Thr Val His Arg Pro Leu Ala Ala Thr Ser Pro 
                85                  90                  95      


Ala Gln Ser Pro Glu Thr Thr Pro Leu Trp Ala Thr Ala Gly Pro Ser 
            100                 105                 110         


Ser Thr Thr Phe Gln Ala Pro Leu Gly Pro Ser Pro Thr Thr Pro Pro 
        115                 120                 125             


Ala Ala Glu Arg Thr Ser Thr Thr Ser Gln Ala Pro Thr Arg Pro Ala 
    130                 135                 140                 


Pro Thr Thr Leu Ser Thr Thr Thr Gly Pro Ala Pro Thr Thr Pro Val 
145                 150                 155                 160 


Ala Thr Thr Val Pro Ala Pro Thr Thr Pro Arg Thr Pro Thr Pro Asp 
                165                 170                 175     


Leu Pro Ser Ser Ser Asn Ser Ser Val Leu Pro Thr Pro Pro Ala Thr 
            180                 185                 190         


Glu Ala Pro Ser Ser Pro Pro Pro Glu Tyr Val Cys Asn Cys Ser Val 
        195                 200                 205             


Val Gly Ser Leu Asn Val Asn Arg Cys Asn Gln Thr Thr Gly Gln Cys 
    210                 215                 220                 


Glu Cys Arg Pro Gly Tyr Gln Gly Leu His Cys Glu Thr Cys Lys Glu 
225                 230                 235                 240 


Gly Phe Tyr Leu Asn Tyr Thr Ser Gly Leu Cys Gln Pro Cys Asp Cys 
                245                 250                 255     


Ser Pro His Gly Ala Leu Ser Ile Pro Cys Asn Ser Ser Gly Lys Cys 
            260                 265                 270         


Gln Cys Lys Val Gly Val Ile Gly Ser Ile Cys Asp Arg Cys Gln Asp 
        275                 280                 285             


Gly Tyr Tyr Gly Phe Ser Lys Asn Gly Cys Leu Pro Cys Gln Cys Asn 
    290                 295                 300                 


Asn Arg Ser Ala Ser Cys Asp Ala Leu Thr Gly Ala Cys Leu Asn Cys 
305                 310                 315                 320 


Gln Glu Asn Ser Lys Gly Asn His Cys Glu Glu Cys Lys Glu Gly Phe 
                325                 330                 335     


Tyr Gln Ser Pro Asp Ala Thr Lys Glu Cys Leu Arg Cys Pro Cys Ser 
            340                 345                 350         


Ala Val Thr Ser Thr Gly Ser Cys Ser Ile Lys Ser Ser Glu Leu Glu 
        355                 360                 365             


Pro Glu Cys Asp Gln Cys Lys Asp Gly Tyr Ile Gly Pro Asn Cys Asn 
    370                 375                 380                 


Lys Cys Glu Asn Gly Tyr Tyr Asn Phe Asp Ser Ile Cys Arg Lys Cys 
385                 390                 395                 400 


Gln Cys His Gly His Val Asp Pro Val Lys Thr Pro Lys Ile Cys Lys 
                405                 410                 415     


Pro Glu Ser Gly Glu Cys Ile Asn Cys Leu His Asn Thr Thr Gly Phe 
            420                 425                 430         


Trp Cys Glu Asn Cys Leu Glu Gly Tyr Val His Asp Leu Glu Gly Asn 
        435                 440                 445             


Cys Ile Lys Lys Glu Val Ile Leu Pro Thr Pro Glu Gly Ser Thr Ile 
    450                 455                 460                 


Leu Val Ser Asn Ala Ser Leu Thr Thr Ser Val Pro Thr Pro Val Ile 
465                 470                 475                 480 


Asn Ser Thr Phe Thr Pro Thr Thr Leu Gln Thr Ile Phe Ser Val Ser 
                485                 490                 495     


Thr Ser Glu Asn Ser Thr Ser Ala Leu Ala Asp Val Ser Trp Thr Gln 
            500                 505                 510         


Phe Asn Ile Ile Ile Leu Thr Val Ile Ile Ile Val Val Val Leu Leu 
        515                 520                 525             


Met Gly Phe Val Gly Ala Val Tyr Met Tyr Arg Glu Tyr Gln Asn Arg 
    530                 535                 540                 


Lys Leu Asn Ala Pro Phe Trp Thr Ile Glu Leu Lys Glu Asp Asn Ile 
545                 550                 555                 560 


Ser Phe Ser Ser Tyr His Asp Ser Ile Pro Asn Ala Asp Val Ser Gly 
                565                 570                 575     


Leu Leu Glu Asp Asp Gly Asn Glu Val Ala Pro Asn Gly Gln Leu Thr 
            580                 585                 590         


Leu Thr Thr Pro Ile His Asn Tyr Lys Ala 
        595                 600         


<210>  1032
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  1032

Met Arg Ala Leu Leu Ala Leu Cys Leu Leu Leu Gly Trp Leu Arg Trp 
1               5                   10                  15      


Gly Pro Ala Gly Ala Gln Gln Ser Gly Glu Tyr Cys His Gly Trp Val 
            20                  25                  30          


Asp Val Gln Gly Asn Tyr His Glu Gly Phe Gln Cys Pro Glu Asp Phe 
        35                  40                  45              


Asp Thr Leu Asp Ala Thr Ile Cys Cys Gly Ser Cys Ala Leu Arg Tyr 
    50                  55                  60                  


Cys Cys Ala Ala Ala Asp Ala Arg Leu Glu Gln Gly Gly Cys Thr Asn 
65                  70                  75                  80  


Asp Arg Arg Glu Leu Glu His Pro Gly Ile Thr Ala Gln Pro Val Tyr 
                85                  90                  95      


Val Pro Phe Leu Ile Val Gly Ser Ile Phe Ile Ala Phe Ile Ile Leu 
            100                 105                 110         


Gly Ser Val Val Ala Ile Tyr Cys Cys Thr Cys Leu Arg Pro Lys Glu 
        115                 120                 125             


Pro Ser Gln Gln Pro Ile Arg Phe Ser Leu Arg Ser Tyr Gln Thr Glu 
    130                 135                 140                 


Thr Leu Pro Met Ile Leu Thr Ser Thr Ser Pro Arg Ala Pro Ser Arg 
145                 150                 155                 160 


Gln Ser Ser Thr Ala Thr Ser Ser Ser Ser Thr Gly Gly Ser Ile Arg 
                165                 170                 175     


Arg Phe Ser Phe Ala Arg Ala Glu Pro Gly Cys Leu Val Pro Ser Pro 
            180                 185                 190         


Pro Pro Pro Tyr Thr Thr Ser His Ser Ile His Leu Ala Gln Pro Ser 
        195                 200                 205             


Gly Phe Leu Val Ser Pro Gln Tyr Phe Ala Tyr Pro Leu Gln Gln Glu 
    210                 215                 220                 


Pro Pro Leu Pro Gly Lys Ser Cys Pro Asp Phe Ser Ser Ser 
225                 230                 235             


<210>  1033
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  1033

Met Asp Gly Lys Lys Cys Ser Val Trp Met Phe Leu Pro Leu Val Phe 
1               5                   10                  15      


Thr Leu Phe Thr Ser Ala Gly Leu Trp Ile Val Tyr Phe Ile Ala Val 
            20                  25                  30          


Glu Asp Asp Lys Ile Leu Pro Leu Asn Ser Ala Glu Arg Lys Pro Gly 
        35                  40                  45              


Val Lys His Ala Pro Tyr Ile Ser Ile Ala Gly Asp Asp Pro Pro Ala 
    50                  55                  60                  


Ser Cys Val Phe Ser Gln Val Met Asn Met Ala Ala Phe Leu Ala Leu 
65                  70                  75                  80  


Val Val Ala Val Leu Arg Phe Ile Gln Leu Lys Pro Lys Val Leu Asn 
                85                  90                  95      


Pro Trp Leu Asn Ile Ser Gly Leu Val Ala Leu Cys Leu Ala Ser Phe 
            100                 105                 110         


Gly Met Thr Leu Leu Gly Asn Phe Gln Leu Thr Asn Asp Glu Glu Ile 
        115                 120                 125             


His Asn Val Gly Thr Ser Leu Thr Phe Gly Phe Gly Thr Leu Thr Cys 
    130                 135                 140                 


Trp Ile Gln Ala Ala Leu Thr Leu Lys Val Asn Ile Lys Asn Glu Gly 
145                 150                 155                 160 


Arg Arg Val Gly Ile Pro Arg Val Ile Leu Ser Ala Ser Ile Thr Leu 
                165                 170                 175     


Cys Val Val Leu Tyr Phe Ile Leu Met Ala Gln Ser Ile His Met Tyr 
            180                 185                 190         


Ala Ala Arg Val Gln Trp Gly Leu Val Met Cys Phe Leu Ser Tyr Phe 
        195                 200                 205             


Gly Thr Phe Ala Val Glu Phe Arg His Tyr Arg Tyr Glu Ile Val Cys 
    210                 215                 220                 


Ser Glu Tyr Gln Glu Asn Phe Leu Ser Phe Ser Glu Ser Leu Ser Glu 
225                 230                 235                 240 


Ala Ser Glu Tyr Gln Thr Asp Gln Val 
                245                 


<210>  1034
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  1034

Met Ala His Tyr Lys Thr Glu Gln Asp Asp Trp Leu Ile Ile Tyr Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Val Phe Asn Phe Phe Phe Trp Val Gly Gly Ala 
            20                  25                  30          


Ala Val Leu Ala Val Gly Ile Trp Thr Leu Val Glu Lys Ser Gly Tyr 
        35                  40                  45              


Leu Ser Val Leu Ala Ser Ser Thr Phe Ala Ala Ser Ala Tyr Ile Leu 
    50                  55                  60                  


Ile Phe Ala Gly Val Leu Val Met Val Thr Gly Phe Leu Gly Phe Gly 
65                  70                  75                  80  


Ala Ile Leu Trp Glu Arg Lys Gly Cys Leu Ser Thr Tyr Phe Cys Leu 
                85                  90                  95      


Leu Leu Val Ile Phe Leu Val Glu Leu Val Ala Gly Val Leu Ala His 
            100                 105                 110         


Val Tyr Tyr Gln Arg Leu Ser Asp Glu Leu Lys Gln His Leu Asn Arg 
        115                 120                 125             


Thr Leu Ala Glu Asn Tyr Gly Gln Pro Gly Ala Thr Gln Ile Thr Ala 
    130                 135                 140                 


Ser Val Asp Arg Leu Gln Gln Asp Phe Lys Cys Cys Gly Ser Asn Ser 
145                 150                 155                 160 


Ser Ala Asp Trp Gln His Ser Thr Tyr Ile Leu Leu Arg Glu Ala Glu 
                165                 170                 175     


Gly Arg Gln Val Pro Asp Ser Cys Cys Lys Thr Val Val Val Arg Cys 
            180                 185                 190         


Gly Gln Arg Ala His Pro Ser Asn Ile Tyr Lys Val Glu Gly Gly Cys 
        195                 200                 205             


Leu Thr Lys Leu Glu Gln Phe Leu Ala Asp His Leu Leu Leu Met Gly 
    210                 215                 220                 


Ala Val Gly Ile Gly Val Ala Cys Leu Gln Ile Cys Gly Met Val Leu 
225                 230                 235                 240 


Thr Cys Cys Leu His Gln Arg Leu Gln Arg His Phe Tyr 
                245                 250             


<210>  1035
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  1035

Met Glu Pro Ala Arg Glu Pro Pro Ser Arg Ala Arg Pro Pro Pro Pro 
1               5                   10                  15      


Leu Ala Ala Arg Pro Ala Pro Ala Pro Ala Ala Pro Arg Pro Arg Ser 
            20                  25                  30          


Pro Ala Glu Ala Glu Ala Arg Gly Pro Glu Gly Leu Leu Arg Arg Ser 
        35                  40                  45              


Gly Ser Gly Tyr Glu Gly Ser Thr Ser Trp Lys Ala Ala Leu Glu Asp 
    50                  55                  60                  


Thr Thr Thr Arg Leu Leu Leu Gly Ala Ile Ala Val Leu Leu Phe Ala 
65                  70                  75                  80  


Ile Leu Val Val Met Ser Ile Leu Ala Ser Lys Gly Cys Ile Lys Cys 
                85                  90                  95      


Glu Ala Pro Cys Pro Glu Asp Trp Leu Leu Tyr Gly Arg Lys Cys Tyr 
            100                 105                 110         


Phe Phe Ser Glu Glu Pro Arg Asp Trp Asn Thr Gly Arg Gln Tyr Cys 
        115                 120                 125             


His Thr His Glu Ala Val Leu Ala Val Ile Gln Ser Gln Lys Glu Leu 
    130                 135                 140                 


Glu Phe Met Phe Lys Phe Thr Arg Arg Glu Pro Trp Ile Gly Leu Arg 
145                 150                 155                 160 


Arg Val Gly Asp Glu Phe His Trp Val Asn Gly Asp Pro Phe Asp Pro 
                165                 170                 175     


Asp Thr Phe Thr Ile Ala Gly Pro Gly Glu Cys Val Phe Val Glu Pro 
            180                 185                 190         


Thr Arg Leu Val Ser Thr Glu Cys Leu Met Thr Arg Pro Trp Val Cys 
        195                 200                 205             


Ser Lys Met Ala Tyr Thr 
    210                 


<210>  1036
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  1036

Met Ala Gly Thr Val Leu Gly Val Gly Ala Gly Val Phe Ile Leu Ala 
1               5                   10                  15      


Leu Leu Trp Val Ala Val Leu Leu Leu Cys Val Leu Leu Ser Arg Ala 
            20                  25                  30          


Ser Gly Ala Ala Arg Phe Ser Val Ile Phe Leu Phe Phe Gly Ala Val 
        35                  40                  45              


Ile Ile Thr Ser Val Leu Leu Leu Phe Pro Arg Ala Gly Glu Phe Pro 
    50                  55                  60                  


Ala Pro Glu Val Glu Val Lys Ile Val Asp Asp Phe Phe Ile Gly Arg 
65                  70                  75                  80  


Tyr Val Leu Leu Ala Phe Leu Ser Ala Ile Phe Leu Gly Gly Leu Phe 
                85                  90                  95      


Leu Val Leu Ile His Tyr Val Leu Glu Pro Ile Tyr Ala Lys Pro Leu 
            100                 105                 110         


His Ser Tyr 
        115 


<210>  1037
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  1037

Met Leu Gln Ala Cys Lys Met Glu Gly Phe Pro Leu Val Pro Pro Gln 
1               5                   10                  15      


Pro Ser Glu Asp Leu Val Pro Tyr Asp Thr Asp Leu Tyr Gln Arg Gln 
            20                  25                  30          


Thr His Glu Tyr Tyr Pro Tyr Leu Ser Ser Asp Gly Glu Ser His Ser 
        35                  40                  45              


Asp His Tyr Trp Asp Phe His Pro His His Val His Ser Glu Phe Glu 
    50                  55                  60                  


Ser Phe Ala Glu Asn Asn Phe Thr Glu Leu Gln Ser Val Gln Pro Pro 
65                  70                  75                  80  


Gln Leu Gln Gln Leu Tyr Arg His Met Glu Leu Glu Gln Met His Val 
                85                  90                  95      


Leu Asp Thr Pro Met Val Pro Pro His Pro Ser Leu Gly His Gln Val 
            100                 105                 110         


Ser Tyr Leu Pro Arg Met Cys Leu Gln Tyr Pro Ser Leu Ser Pro Ala 
        115                 120                 125             


Gln Pro Ser Ser Asp Glu Glu Glu Gly Glu Arg Gln Ser Pro Pro Leu 
    130                 135                 140                 


Glu Val Ser Asp Gly Glu Ala Asp Gly Leu Glu Pro Gly Pro Gly Leu 
145                 150                 155                 160 


Leu Pro Gly Glu Thr Gly Ser Lys Lys Lys Ile Arg Leu Tyr Gln Phe 
                165                 170                 175     


Leu Leu Asp Leu Leu Arg Ser Gly Asp Met Lys Asp Ser Ile Trp Trp 
            180                 185                 190         


Val Asp Lys Asp Lys Gly Thr Phe Gln Phe Ser Ser Lys His Lys Glu 
        195                 200                 205             


Ala Leu Ala His Arg Trp Gly Ile Gln Lys Gly Asn Arg Lys Lys Met 
    210                 215                 220                 


Thr Tyr Gln Lys Met Ala Arg Ala Leu Arg Asn Tyr Gly Lys Thr Gly 
225                 230                 235                 240 


Glu Val Lys Lys Val Lys Lys Lys Leu Thr Tyr Gln Phe Ser Gly Glu 
                245                 250                 255     


Val Leu Gly Arg Gly Gly Leu Ala Glu Arg Arg His Pro Pro His 
            260                 265                 270     


<210>  1038
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  1038

Met Ser Asp Pro Ser Gln Leu Thr Gln Asn Val Cys Leu Thr Gln Glu 
1               5                   10                  15      


Met Glu Leu Ser Lys Ala Phe Ser Gly Gln Arg Thr Leu Leu Ser Ala 
            20                  25                  30          


Ile Leu Ser Met Leu Ser Leu Ser Phe Ser Thr Thr Ser Leu Leu Ser 
        35                  40                  45              


Asn Tyr Trp Phe Val Gly Thr Gln Lys Val Pro Lys Pro Leu Cys Glu 
    50                  55                  60                  


Lys Gly Leu Ala Ala Lys Cys Phe Asp Met Pro Val Ser Leu Asp Gly 
65                  70                  75                  80  


Asp Thr Asn Thr Ser Thr Gln Glu Val Val Gln Tyr Asn Trp Glu Thr 
                85                  90                  95      


Gly Asp Asp Arg Phe Ser Phe Arg Ser Phe Arg Ser Gly Met Trp Leu 
            100                 105                 110         


Ser Cys Glu Glu Thr Val Glu Glu Pro Ala Leu Leu His Pro Gln Ser 
        115                 120                 125             


Trp Lys Gln Phe Arg Ala Leu Arg Ser Ser Gly Thr Ala Ala Ala Lys 
    130                 135                 140                 


Gly Glu Arg Cys Arg Ser Phe Ile Glu Leu Thr Pro Pro Ala Lys Arg 
145                 150                 155                 160 


Gly Glu Lys Gly Leu Leu Glu Phe Ala Thr Leu Gln Gly Pro Cys His 
                165                 170                 175     


Pro Thr Leu Arg Phe Gly Gly Lys Arg Leu Met Glu Lys Ala Ser Leu 
            180                 185                 190         


Pro Ser Pro Pro Leu Gly Leu Cys Gly Lys Asn Pro Met Val Ile Pro 
        195                 200                 205             


Gly Asn Ala Asp His Leu His Arg Thr Ser Ile His Gln Leu Pro Pro 
    210                 215                 220                 


Ala Thr Asn Arg Leu Ala Thr His Trp Glu Pro Cys Leu Trp Ala Gln 
225                 230                 235                 240 


Thr Glu Arg Leu Cys Cys Cys Phe Leu Cys Pro Val Arg Ser Pro Gly 
                245                 250                 255     


Asp Gly Gly Pro His Asp Val Phe Thr Ser Leu Pro Ser Asp Cys Gln 
            260                 265                 270         


Leu Gly Ser Arg Arg Leu Glu Thr Thr Cys Leu Glu Leu Trp Leu Gly 
        275                 280                 285             


Leu Leu His Gly Leu Ala Leu Leu His Leu Leu His Gly Val Gly Cys 
    290                 295                 300                 


His His Leu Gln His Val His Gln Asp Gly Ala Gly Val Gln Val Gln 
305                 310                 315                 320 


Ala 
    


<210>  1039
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  1039

Met Ser Asp Pro Ser Gln Leu Thr Gln Asn Val Cys Leu Thr Gln Glu 
1               5                   10                  15      


Met Glu Leu Ser Lys Ala Phe Ser Gly Gln Arg Thr Leu Leu Ser Ala 
            20                  25                  30          


Ile Leu Ser Met Leu Ser Leu Ser Phe Ser Thr Thr Ser Leu Leu Ser 
        35                  40                  45              


Asn Tyr Trp Phe Val Gly Thr Gln Lys Val Pro Lys Pro Leu Cys Glu 
    50                  55                  60                  


Lys Gly Leu Ala Ala Lys Cys Phe Asp Met Pro Val Ser Leu Asp Gly 
65                  70                  75                  80  


Asp Thr Asn Thr Ser Thr Gln Glu Val Val Gln Tyr Asn Trp Glu Thr 
                85                  90                  95      


Gly Asp Asp Arg Phe Ser Phe Arg Ser Phe Arg Ser Gly Met Trp Leu 
            100                 105                 110         


Ser Cys Glu Glu Thr Val Glu Glu Pro Ala Leu Leu His Pro Gln Ser 
        115                 120                 125             


Trp Lys Gln Phe Arg Ala Leu Arg Ser Ser Gly Thr Ala Ala Ala Lys 
    130                 135                 140                 


Gly Glu Arg Cys Arg Ser Phe Ile Glu Leu Thr Pro Pro Ala Lys Arg 
145                 150                 155                 160 


Glu Ile Leu Trp Leu Ser Leu Gly Thr Gln Ile Thr Tyr Ile Gly Leu 
                165                 170                 175     


Gln Phe Ile Ser Phe Leu Leu Leu Leu Thr Asp Leu Leu Leu Thr Gly 
            180                 185                 190         


Asn Pro Ala Cys Gly Leu Lys Leu Ser Ala Phe Ala Ala Val Ser Ser 
        195                 200                 205             


Val Leu Ser Gly Leu Leu Gly Met Val Ala His Met Met Tyr Ser Gln 
    210                 215                 220                 


Val Phe Gln Ala Thr Val Asn Leu Gly Pro Glu Asp Trp Arg Pro His 
225                 230                 235                 240 


Val Trp Asn Tyr Gly Trp Ala Phe Tyr Met Ala Trp Leu Ser Phe Thr 
                245                 250                 255     


Cys Cys Met Ala Ser Ala Val Thr Thr Phe Asn Thr Tyr Thr Arg Met 
            260                 265                 270         


Val Leu Glu Phe Lys Cys Lys His Ser Lys Ser Phe Lys Glu Asn Pro 
        275                 280                 285             


Asn Cys Leu Pro His His His Gln Cys Phe Pro Arg Arg Leu Ser Ser 
    290                 295                 300                 


Ala Ala Pro Thr Val Gly Pro Leu Thr Ser Tyr His Gln Tyr His Asn 
305                 310                 315                 320 


Gln Pro Ile His Ser Val Ser Glu Gly Val Asp Phe Tyr Ser Glu Leu 
                325                 330                 335     


Arg Asn Lys Gly Phe Gln Arg Gly Ala Ser Gln Glu Leu Lys Glu Ala 
            340                 345                 350         


Val Arg Ser Ser Val Glu Glu Glu Gln Cys 
        355                 360         


<210>  1040
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  1040

Met Ser Met Ser Pro Thr Val Ile Ile Leu Ala Cys Leu Gly Phe Phe 
1               5                   10                  15      


Leu Asp Gln Ser Val Trp Ala His Val Gly Gly Gln Asp Lys Pro Phe 
            20                  25                  30          


Cys Ser Ala Trp Pro Ser Ala Val Val Pro Gln Gly Gly His Val Thr 
        35                  40                  45              


Leu Arg Cys His Tyr Arg Arg Gly Phe Asn Ile Phe Thr Leu Tyr Lys 
    50                  55                  60                  


Lys Asp Gly Val Pro Val Pro Glu Leu Tyr Asn Arg Ile Phe Trp Asn 
65                  70                  75                  80  


Ser Phe Leu Ile Ser Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg 
                85                  90                  95      


Cys Arg Gly Phe His Pro His Ser Pro Thr Glu Trp Ser Ala Pro Ser 
            100                 105                 110         


Asn Pro Leu Val Ile Met Val Thr Gly Leu Tyr Glu Lys Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Pro Gly Pro Thr Val Arg Ala Gly Glu Asn Val Thr Leu 
    130                 135                 140                 


Ser Cys Ser Ser Gln Ser Ser Phe Asp Ile Tyr His Leu Ser Arg Glu 
145                 150                 155                 160 


Gly Glu Ala His Glu Leu Arg Leu Pro Ala Val Pro Ser Ile Asn Gly 
                165                 170                 175     


Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly Glu Thr 
            180                 185                 190         


Tyr Arg Cys Phe Gly Ser Phe His Gly Ser Pro Tyr Glu Trp Ser Asp 
        195                 200                 205             


Pro Ser Asp Pro Leu Pro Val Ser Val Thr Gly Asn Pro Ser Ser Ser 
    210                 215                 220                 


Trp Pro Ser Pro Thr Glu Pro Ser Phe Lys Thr Asp Ala Ala Val Met 
225                 230                 235                 240 


Asn Gln Glu Pro Ala Gly His Arg Thr Val Asn Arg Glu Asp Ser Asp 
                245                 250                 255     


Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln Leu Asp His Cys Ile 
            260                 265                 270         


Phe Thr Gln Arg Lys Ile Thr Gly Pro Ser Gln Arg Ser Lys Arg Pro 
        275                 280                 285             


Ser Thr Asp Thr Ser Val Cys Ile Glu Leu Pro Asn Ala Glu Pro Arg 
    290                 295                 300                 


Ala Leu Ser Pro Ala His Glu His His Ser Gln Ala Leu Met Gly Ser 
305                 310                 315                 320 


Ser Arg Glu Thr Thr Ala Leu Ser Gln Thr Gln Leu Ala Ser Ser Asn 
                325                 330                 335     


Val Pro Ala Ala Gly Ile 
            340         


<210>  1041
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  1041

Met Ser Met Ser Pro Thr Val Ile Ile Leu Ala Cys Leu Gly Phe Phe 
1               5                   10                  15      


Leu Asp Gln Ser Val Trp Ala His Val Gly Gly Gln Asp Lys Pro Phe 
            20                  25                  30          


Cys Ser Ala Trp Pro Ser Ala Val Val Pro Gln Gly Gly His Val Thr 
        35                  40                  45              


Leu Arg Cys His Tyr Arg Arg Gly Phe Asn Ile Phe Thr Leu Tyr Lys 
    50                  55                  60                  


Lys Asp Gly Val Pro Val Pro Glu Leu Tyr Asn Arg Ile Phe Trp Asn 
65                  70                  75                  80  


Ser Phe Leu Ile Ser Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg 
                85                  90                  95      


Cys Arg Gly Phe His Pro His Ser Pro Thr Glu Trp Ser Ala Pro Ser 
            100                 105                 110         


Asn Pro Leu Val Ile Met Val Thr Gly Leu Tyr Glu Lys Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Pro Gly Pro Thr Val Arg Ala Gly Glu Asn Val Thr Leu 
    130                 135                 140                 


Ser Cys Ser Ser Gln Ser Ser Phe Asp Ile Tyr His Leu Ser Arg Glu 
145                 150                 155                 160 


Gly Glu Ala His Glu Leu Arg Leu Pro Ala Val Pro Ser Ile Asn Gly 
                165                 170                 175     


Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly Glu Thr 
            180                 185                 190         


Tyr Arg Cys Phe Gly Ser Phe His Gly Ser Pro Tyr Glu Trp Ser Asp 
        195                 200                 205             


Pro Ser Asp Pro Leu Pro Val Ser Val Thr Gly Asn Pro Ser Ser Ser 
    210                 215                 220                 


Trp Pro Ser Pro Thr Glu Pro Ser Phe Lys Thr Gly Ile Ala Arg His 
225                 230                 235                 240 


Leu His Ala Val Ile Arg Tyr Ser Val Ala Ile Ile Leu Phe Thr Ile 
                245                 250                 255     


Leu Pro Phe Phe Leu Leu His Arg Trp Cys Ser Lys Lys Lys Met Leu 
            260                 265                 270         


Leu 
    


<210>  1042
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  1042

Met Ser Gly Gln Leu Glu Arg Cys Glu Arg Glu Trp His Glu Leu Glu 
1               5                   10                  15      


Gly Glu Phe Gln Glu Leu Gln Glu Thr His Arg Ile Tyr Lys Gln Lys 
            20                  25                  30          


Leu Glu Glu Leu Ala Ala Leu Gln Thr Leu Cys Ser Ser Ser Ile Ser 
        35                  40                  45              


Lys Gln Lys Lys His Leu Lys Asp Leu Lys Leu Thr Leu Gln Arg Cys 
    50                  55                  60                  


Lys Arg His Ala Ser Arg Glu Glu Ala Glu Leu Val Gln Gln Met Ala 
65                  70                  75                  80  


Ala Asn Ile Lys Glu Arg Gln Asp Val Phe Phe Asp Met Glu Ala Tyr 
                85                  90                  95      


Leu Pro Lys Lys Asn Gly Leu Tyr Leu Asn Leu Val Leu Gly Asn Val 
            100                 105                 110         


Asn Val Thr Leu Leu Ser Asn Gln Ala Lys Phe Ala Tyr Lys Asp Glu 
        115                 120                 125             


Tyr Glu Lys Phe Lys Leu Tyr Leu Thr Ile Ile Leu Leu Leu Gly Ala 
    130                 135                 140                 


Val Ala Cys Arg Phe Val Leu His Tyr Arg Val Thr Asp Glu Val Phe 
145                 150                 155                 160 


Asn Phe Leu Leu Val Trp Tyr Tyr Cys Thr Leu Thr Ile Arg Glu Ser 
                165                 170                 175     


Ile Leu Ile Ser Asn Gly Ser Arg Ile Lys Gly Trp Trp Val Ser His 
            180                 185                 190         


His Tyr Val Ser Thr Phe Leu Ser Gly Val Met Leu Thr Trp Pro Asn 
        195                 200                 205             


Gly Pro Ile Tyr Gln Lys Phe Arg Asn Gln Phe Leu Ala Phe Ser Ile 
    210                 215                 220                 


Phe Gln Ser Cys Val Gln Phe Leu Gln Tyr Tyr Tyr Gln Arg Gly Cys 
225                 230                 235                 240 


Leu Tyr Arg Leu Arg Ala Leu Gly Glu Arg Asn His Leu Asp Leu Thr 
                245                 250                 255     


Val Glu Gly Phe Gln Ser Trp Met Trp Arg Gly Leu Thr Phe Leu Leu 
            260                 265                 270         


Pro Phe Leu Phe Cys Gly His Phe Trp Gln Leu Tyr Asn Ala Val Thr 
        275                 280                 285             


Leu Phe Glu Leu Ser Ser His Glu Glu Cys Arg Glu Trp Gln Val Phe 
    290                 295                 300                 


Val Leu Ala Phe Thr Phe Leu Ile Leu Phe Leu Gly Asn Phe Leu Thr 
305                 310                 315                 320 


Thr Leu Lys Val Val His Ala Lys Leu Gln Lys Asn Arg Gly Lys Thr 
                325                 330                 335     


Lys Gln Pro 
            


<210>  1043
<211>  958
<212>  PRT
<213>  Homo sapiens

<400>  1043

Met Arg Thr His Thr Arg Gly Ala Pro Ser Val Phe Phe Ile Tyr Leu 
1               5                   10                  15      


Leu Cys Phe Val Ser Ala Tyr Ile Thr Asp Glu Asn Pro Glu Val Met 
            20                  25                  30          


Ile Pro Phe Thr Asn Ala Asn Tyr Asp Ser His Pro Met Leu Tyr Phe 
        35                  40                  45              


Ser Arg Ala Glu Val Ala Glu Leu Gln Leu Arg Ala Ala Ser Ser His 
    50                  55                  60                  


Glu His Ile Ala Ala Arg Leu Thr Glu Ala Val His Thr Met Leu Ser 
65                  70                  75                  80  


Ser Pro Leu Glu Tyr Leu Pro Pro Trp Asp Pro Lys Asp Tyr Ser Ala 
                85                  90                  95      


Arg Trp Asn Glu Ile Phe Gly Asn Asn Leu Gly Ala Leu Ala Met Phe 
            100                 105                 110         


Cys Val Leu Tyr Pro Glu Asn Ile Glu Ala Arg Asp Met Ala Lys Asp 
        115                 120                 125             


Tyr Met Glu Arg Met Ala Ala Gln Pro Ser Trp Leu Val Lys Asp Ala 
    130                 135                 140                 


Pro Trp Asp Glu Val Pro Leu Ala His Ser Leu Val Gly Phe Ala Thr 
145                 150                 155                 160 


Ala Tyr Asp Phe Leu Tyr Asn Tyr Leu Ser Lys Thr Gln Gln Glu Lys 
                165                 170                 175     


Phe Leu Glu Val Ile Ala Asn Ala Ser Gly Tyr Met Tyr Glu Thr Ser 
            180                 185                 190         


Tyr Arg Arg Gly Trp Gly Phe Gln Tyr Leu His Asn His Gln Pro Thr 
        195                 200                 205             


Asn Cys Met Ala Leu Leu Thr Gly Ser Leu Val Leu Met Asn Gln Gly 
    210                 215                 220                 


Tyr Leu Gln Glu Ala Tyr Leu Trp Thr Lys Gln Val Leu Thr Ile Met 
225                 230                 235                 240 


Glu Lys Ser Leu Val Leu Leu Arg Glu Val Thr Asp Gly Ser Leu Tyr 
                245                 250                 255     


Glu Gly Val Ala Tyr Gly Ser Tyr Thr Thr Arg Ser Leu Phe Gln Tyr 
            260                 265                 270         


Met Phe Leu Val Gln Arg His Phe Asn Ile Asn His Phe Gly His Pro 
        275                 280                 285             


Trp Leu Lys Gln His Phe Ala Phe Met Tyr Arg Thr Ile Leu Pro Gly 
    290                 295                 300                 


Phe Gln Arg Thr Val Ala Ile Ala Asp Ser Asn Tyr Asn Trp Phe Tyr 
305                 310                 315                 320 


Gly Pro Glu Ser Gln Leu Val Phe Leu Asp Lys Phe Val Met Arg Asn 
                325                 330                 335     


Gly Ser Gly Asn Trp Leu Ala Asp Gln Ile Arg Arg Asn Arg Val Val 
            340                 345                 350         


Glu Gly Pro Gly Thr Pro Ser Lys Gly Gln Arg Trp Cys Thr Leu His 
        355                 360                 365             


Thr Glu Phe Leu Trp Tyr Asp Gly Ser Leu Lys Ser Val Pro Pro Pro 
    370                 375                 380                 


Asp Phe Gly Thr Pro Thr Leu His Tyr Phe Glu Asp Trp Gly Val Val 
385                 390                 395                 400 


Thr Tyr Gly Ser Ala Leu Pro Ala Glu Ile Asn Arg Ser Phe Leu Ser 
                405                 410                 415     


Phe Lys Ser Gly Lys Leu Gly Gly Arg Ala Ile Tyr Asp Ile Val His 
            420                 425                 430         


Arg Asn Lys Tyr Lys Asp Trp Ile Lys Gly Trp Arg Asn Phe Asn Ala 
        435                 440                 445             


Gly His Glu His Pro Asp Gln Asn Ser Phe Thr Phe Ala Pro Asn Gly 
    450                 455                 460                 


Val Pro Phe Ile Thr Glu Ala Leu Tyr Gly Pro Lys Tyr Thr Phe Phe 
465                 470                 475                 480 


Asn Asn Val Leu Met Phe Ser Pro Ala Val Ser Lys Ser Cys Phe Ser 
                485                 490                 495     


Pro Trp Val Gly Gln Val Thr Glu Asp Cys Ser Ser Lys Trp Ser Lys 
            500                 505                 510         


Tyr Lys His Asp Leu Ala Ala Ser Cys Gln Gly Arg Val Val Ala Ala 
        515                 520                 525             


Glu Glu Lys Asn Gly Val Val Phe Ile Arg Gly Glu Gly Val Gly Ala 
    530                 535                 540                 


Tyr Asn Pro Gln Leu Asn Leu Lys Asn Val Gln Arg Asn Leu Ile Leu 
545                 550                 555                 560 


Leu His Pro Gln Leu Leu Leu Leu Val Asp Gln Ile His Leu Gly Glu 
                565                 570                 575     


Glu Ser Pro Leu Glu Thr Ala Ala Ser Phe Phe His Asn Val Asp Val 
            580                 585                 590         


Pro Phe Glu Glu Thr Val Val Asp Gly Val His Gly Ala Phe Ile Arg 
        595                 600                 605             


Gln Arg Asp Gly Leu Tyr Lys Met Tyr Trp Met Asp Asp Thr Gly Tyr 
    610                 615                 620                 


Ser Glu Lys Ala Thr Phe Ala Ser Val Thr Tyr Pro Arg Gly Tyr Pro 
625                 630                 635                 640 


Tyr Asn Gly Thr Asn Tyr Val Asn Val Thr Met His Leu Arg Ser Pro 
                645                 650                 655     


Ile Thr Arg Ala Ala Tyr Leu Phe Ile Gly Pro Ser Ile Asp Val Gln 
            660                 665                 670         


Ser Phe Thr Val His Gly Asp Ser Gln Gln Leu Asp Val Phe Ile Ala 
        675                 680                 685             


Thr Ser Lys His Ala Tyr Ala Thr Tyr Leu Trp Thr Gly Glu Ala Thr 
    690                 695                 700                 


Gly Gln Ser Ala Phe Ala Gln Val Ile Ala Asp Arg His Lys Ile Leu 
705                 710                 715                 720 


Phe Asp Arg Asn Ser Ala Ile Lys Ser Ser Ile Val Pro Glu Val Lys 
                725                 730                 735     


Asp Tyr Ala Ala Ile Val Glu Gln Asn Leu Gln His Phe Lys Pro Val 
            740                 745                 750         


Phe Gln Leu Leu Glu Lys Gln Ile Leu Ser Arg Val Arg Asn Thr Ala 
        755                 760                 765             


Ser Phe Arg Lys Thr Ala Glu Arg Leu Leu Arg Phe Ser Asp Lys Arg 
    770                 775                 780                 


Gln Thr Glu Glu Ala Ile Asp Arg Ile Phe Ala Ile Ser Gln Gln Gln 
785                 790                 795                 800 


Gln Gln Gln Ser Lys Ser Lys Lys Asn Arg Arg Ala Gly Lys Arg Tyr 
                805                 810                 815     


Lys Phe Val Asp Ala Val Pro Asp Ile Phe Ala Gln Ile Glu Val Asn 
            820                 825                 830         


Glu Lys Lys Ile Arg Gln Lys Ala Gln Ile Leu Ala Gln Lys Glu Leu 
        835                 840                 845             


Pro Ile Asp Glu Asp Glu Glu Met Lys Asp Leu Leu Asp Phe Ala Asp 
    850                 855                 860                 


Val Thr Tyr Glu Lys His Lys Asn Gly Gly Leu Ile Lys Gly Arg Phe 
865                 870                 875                 880 


Gly Gln Ala Arg Met Val Thr Thr Thr His Ser Arg Ala Pro Ser Leu 
                885                 890                 895     


Ser Ala Ser Tyr Thr Arg Leu Phe Leu Ile Leu Asn Ile Ala Ile Phe 
            900                 905                 910         


Phe Val Met Leu Ala Met Gln Leu Thr Tyr Phe Gln Arg Ala Gln Ser 
        915                 920                 925             


Leu His Gly Gln Arg Cys Leu Tyr Ala Val Leu Leu Ile Asp Ser Cys 
    930                 935                 940                 


Ile Leu Leu Trp Leu Tyr Ser Ser Cys Ser Gln Ser Gln Cys 
945                 950                 955             


<210>  1044
<211>  597
<212>  PRT
<213>  Homo sapiens

<400>  1044

Met Thr Pro Ile Val Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr Arg Val Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Asp Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser 
        35                  40                  45              


Cys Gln Gly Ser Leu Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys 
    50                  55                  60                  


Lys Ser Ala Ser Trp Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn 
65                  70                  75                  80  


Gly Gln Phe His Ile Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr 
                85                  90                  95      


Gly Cys Gln Tyr Tyr Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro 
            100                 105                 110         


Leu Val Leu Val Met Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala 
        115                 120                 125             


Gln Pro Ser Pro Val Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys 
    130                 135                 140                 


Glu Ser Gln Val Ala Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu 
145                 150                 155                 160 


Asp Glu His Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser 
                165                 170                 175     


Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp 
            180                 185                 190         


Ser His Arg Cys Tyr Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser 
        195                 200                 205             


Ser Pro Ser Asp Leu Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys 
    210                 215                 220                 


Pro Ser Leu Ser Val Gln Pro Gly Pro Val Met Ala Pro Gly Glu Ser 
225                 230                 235                 240 


Leu Thr Leu Gln Cys Val Ser Asp Val Gly Tyr Asp Arg Phe Val Leu 
                245                 250                 255     


Tyr Lys Glu Gly Glu Arg Asp Leu Arg Gln Leu Pro Gly Arg Gln Pro 
            260                 265                 270         


Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg 
        275                 280                 285             


Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser 
    290                 295                 300                 


Glu Cys Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln 
305                 310                 315                 320 


Ile Arg Gly Thr Pro Phe Ile Ser Val Gln Pro Gly Pro Thr Val Ala 
                325                 330                 335     


Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Trp Arg Gln Phe His 
            340                 345                 350         


Thr Phe Leu Leu Thr Lys Ala Gly Ala Ala Asp Ala Pro Leu Arg Leu 
        355                 360                 365             


Arg Ser Ile His Glu Tyr Pro Lys Tyr Gln Ala Glu Phe Pro Met Ser 
    370                 375                 380                 


Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Leu 
385                 390                 395                 400 


Asn Ser Asp Pro Tyr Leu Leu Ser His Pro Ser Glu Pro Leu Glu Leu 
                405                 410                 415     


Val Val Ser Gly Pro Ser Met Gly Ser Ser Pro Pro Pro Thr Gly Pro 
            420                 425                 430         


Ile Ser Thr Pro Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser 
        435                 440                 445             


Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly Ile 
    450                 455                 460                 


Leu Val Ala Val Val Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe Leu 
465                 470                 475                 480 


Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln Arg 
                485                 490                 495     


Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro Thr 
            500                 505                 510         


Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln Glu 
        515                 520                 525             


Glu Asn Leu Tyr Ala Ala Val Lys Asp Thr Gln Pro Glu Asp Gly Val 
    530                 535                 540                 


Glu Met Asp Thr Arg Ala Ala Ala Ser Glu Ala Pro Gln Asp Val Thr 
545                 550                 555                 560 


Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Lys Ala Thr Glu Pro 
                565                 570                 575     


Pro Pro Ser Gln Glu Arg Glu Pro Pro Ala Glu Pro Ser Ile Tyr Ala 
            580                 585                 590         


Thr Leu Ala Ile His 
        595         


<210>  1045
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  1045

Met Ile Pro Thr Phe Thr Ala Leu Leu Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Met Gln Ala Gly Pro Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Ser Trp Gly Asn Ser Val Thr Ile Trp 
        35                  40                  45              


Cys Gln Gly Thr Leu Glu Ala Arg Glu Tyr Arg Leu Asp Lys Glu Glu 
    50                  55                  60                  


Ser Pro Ala Pro Trp Asp Arg Gln Asn Pro Leu Glu Pro Lys Asn Lys 
65                  70                  75                  80  


Ala Arg Phe Ser Ile Pro Ser Met Thr Glu Asp Tyr Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys Tyr Tyr Arg Ser Pro Val Gly Trp Ser Gln Pro Ser Asp Pro 
            100                 105                 110         


Leu Glu Leu Val Met Thr Gly Ala Tyr Ser Lys Pro Thr Leu Ser Ala 
        115                 120                 125             


Leu Pro Ser Pro Leu Val Thr Ser Gly Lys Ser Val Thr Leu Leu Cys 
    130                 135                 140                 


Gln Ser Arg Ser Pro Met Asp Thr Phe Leu Leu Ile Lys Glu Arg Ala 
145                 150                 155                 160 


Ala His Pro Leu Leu His Leu Arg Ser Glu His Gly Ala Gln Gln His 
                165                 170                 175     


Gln Ala Glu Phe Pro Met Ser Pro Val Thr Ser Val His Gly Gly Thr 
            180                 185                 190         


Tyr Arg Cys Phe Ser Ser His Gly Phe Ser His Tyr Leu Leu Ser His 
        195                 200                 205             


Pro Ser Asp Pro Leu Glu Leu Ile Val Ser Gly Ser Leu Glu Gly Pro 
    210                 215                 220                 


Arg Pro Ser Pro Thr Arg Ser Val Ser Thr Ala Ala Gly Pro Glu Asp 
225                 230                 235                 240 


Gln Pro Leu Met Pro Thr Gly Ser Val Pro His Ser Gly Leu Arg Arg 
                245                 250                 255     


His Trp Glu Val Leu Ile Gly Val Leu Val Val Ser Ile Leu Leu Leu 
            260                 265                 270         


Ser Leu Leu Leu Phe Leu Leu Leu Gln His Trp Arg Gln Gly Lys His 
        275                 280                 285             


Arg Thr Leu Ala Gln Arg Gln Ala Asp Phe Gln Arg Pro Pro Gly Ala 
    290                 295                 300                 


Ala Glu Pro Glu Pro Lys Asp Gly Gly Leu Gln Arg Arg Ser Ser Pro 
305                 310                 315                 320 


Ala Ala Asp Val Gln Gly Glu Asn Phe Cys Ala Ala Val Lys Asn Thr 
                325                 330                 335     


Gln Pro Glu Asp Gly Val Glu Met Asp Thr Arg Gln Ser Pro His Asp 
            340                 345                 350         


Glu Asp Pro Gln Ala Val Thr Tyr Ala Lys Val Lys His Ser Arg Pro 
        355                 360                 365             


Arg Arg Glu Met Ala Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu 
    370                 375                 380                 


Asp Thr Lys Asp Arg Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu 
385                 390                 395                 400 


Ala Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Arg Leu His 
                405                 410                 415     


Ser Phe Thr Leu Arg Gln Lys Ala Thr Glu Pro Pro Pro Ser Gln Glu 
            420                 425                 430         


Gly Ala Ser Pro Ala Glu Pro Ser Val Tyr Ala Thr Leu Ala Ile His 
        435                 440                 445             


<210>  1046
<211>  591
<212>  PRT
<213>  Homo sapiens

<400>  1046

Met Thr Leu Thr Leu Ser Val Leu Ile Cys Leu Gly Leu Ser Val Gly 
1               5                   10                  15      


Pro Arg Thr Cys Val Gln Ala Gly Thr Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Ala Ser Val Ile Ala Arg Gly Lys Pro Val Thr Leu Trp 
        35                  40                  45              


Cys Gln Gly Pro Leu Glu Thr Glu Glu Tyr Arg Leu Asp Lys Glu Gly 
    50                  55                  60                  


Leu Pro Trp Ala Arg Lys Arg Gln Asn Pro Leu Glu Pro Gly Ala Lys 
65                  70                  75                  80  


Ala Lys Phe His Ile Pro Ser Thr Val Tyr Asp Ser Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys Tyr Tyr Glu Thr Pro Ala Gly Trp Ser Glu Pro Ser Asp Pro 
            100                 105                 110         


Leu Glu Leu Val Ala Thr Gly Phe Tyr Ala Glu Pro Thr Leu Leu Ala 
        115                 120                 125             


Leu Pro Ser Pro Val Val Ala Ser Gly Gly Asn Val Thr Leu Gln Cys 
    130                 135                 140                 


Asp Thr Leu Asp Gly Leu Leu Thr Phe Val Leu Val Glu Glu Glu Gln 
145                 150                 155                 160 


Lys Leu Pro Arg Thr Leu Tyr Ser Gln Lys Leu Pro Lys Gly Pro Ser 
                165                 170                 175     


Gln Ala Leu Phe Pro Val Gly Pro Val Thr Pro Ser Cys Arg Trp Arg 
            180                 185                 190         


Phe Arg Cys Tyr Tyr Tyr Tyr Arg Lys Asn Pro Gln Val Trp Ser Asn 
        195                 200                 205             


Pro Ser Asp Leu Leu Glu Ile Leu Val Pro Gly Val Ser Arg Lys Pro 
    210                 215                 220                 


Ser Leu Leu Ile Pro Gln Gly Ser Val Val Ala Arg Gly Gly Ser Leu 
225                 230                 235                 240 


Thr Leu Gln Cys Arg Ser Asp Val Gly Tyr Asp Ile Phe Val Leu Tyr 
                245                 250                 255     


Lys Glu Gly Glu His Asp Leu Val Gln Gly Ser Gly Gln Gln Pro Gln 
            260                 265                 270         


Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg Ser 
        275                 280                 285             


His Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Pro Arg 
    290                 295                 300                 


Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Ala Gly Leu Ile 
305                 310                 315                 320 


Pro Asp Ile Pro Ala Leu Ser Val Gln Pro Gly Pro Lys Val Ala Ser 
                325                 330                 335     


Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Trp His Gln Ile Asp Thr 
            340                 345                 350         


Phe Phe Leu Thr Lys Glu Gly Ala Ala His Pro Pro Leu Cys Leu Lys 
        355                 360                 365             


Ser Lys Tyr Gln Ser Tyr Arg His Gln Ala Glu Phe Ser Met Ser Pro 
    370                 375                 380                 


Val Thr Ser Ala Gln Gly Gly Thr Tyr Arg Cys Tyr Ser Ala Ile Arg 
385                 390                 395                 400 


Ser Tyr Pro Tyr Leu Leu Ser Ser Pro Ser Tyr Pro Gln Glu Leu Val 
                405                 410                 415     


Val Ser Gly Pro Ser Gly Asp Pro Ser Leu Ser Pro Thr Gly Ser Thr 
            420                 425                 430         


Pro Thr Pro Ala Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Leu 
        435                 440                 445             


Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Thr Gly Val 
    450                 455                 460                 


Ser Val Ala Phe Val Leu Leu Leu Phe Leu Leu Leu Phe Leu Leu Leu 
465                 470                 475                 480 


Arg His Arg His Gln Ser Lys His Arg Thr Ser Ala His Phe Tyr Arg 
                485                 490                 495     


Pro Ala Gly Ala Ala Gly Pro Glu Pro Lys Asp Gln Gly Leu Gln Lys 
            500                 505                 510         


Arg Ala Ser Pro Val Ala Asp Ile Gln Glu Glu Ile Leu Asn Ala Ala 
        515                 520                 525             


Val Lys Asp Thr Gln Pro Lys Asp Gly Val Glu Met Asp Ala Arg Ala 
    530                 535                 540                 


Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser 
545                 550                 555                 560 


Leu Thr Leu Arg Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Arg 
                565                 570                 575     


Glu Pro Pro Ala Glu Pro Ser Ile Tyr Ala Pro Leu Ala Ile His 
            580                 585                 590     


<210>  1047
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  1047

Met Thr Leu Thr Leu Ser Val Leu Ile Cys Leu Gly Leu Ser Val Gly 
1               5                   10                  15      


Pro Arg Thr Cys Val Gln Ala Gly Thr Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Ala Ser Val Ile Ala Arg Gly Lys Pro Val Thr Leu Trp 
        35                  40                  45              


Cys Gln Gly Pro Leu Glu Thr Glu Glu Tyr Arg Leu Asp Lys Glu Gly 
    50                  55                  60                  


Leu Pro Trp Ala Arg Lys Arg Gln Asn Pro Leu Glu Pro Gly Ala Lys 
65                  70                  75                  80  


Ala Lys Phe His Ile Pro Ser Thr Val Tyr Asp Ser Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys Tyr Tyr Glu Thr Pro Ala Gly Trp Ser Glu Pro Ser Asp Pro 
            100                 105                 110         


Leu Glu Leu Val Ala Thr Gly Val Ser Arg Lys Pro Ser Leu Leu Ile 
        115                 120                 125             


Pro Gln Gly Ser Val Val Ala Arg Gly Gly Ser Leu Thr Leu Gln Cys 
    130                 135                 140                 


Arg Ser Asp Val Gly Tyr Asp Ile Phe Val Leu Tyr Lys Glu Gly Glu 
145                 150                 155                 160 


His Asp Leu Val Gln Gly Ser Gly Gln Gln Pro Gln Ala Gly Leu Ser 
                165                 170                 175     


Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg Ser His Gly Gly Gln 
            180                 185                 190         


Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Pro Arg Trp Ser Ala Pro 
        195                 200                 205             


Ser Asp Pro Leu Asp Ile Leu Ile Ala Gly Leu Ile Pro Asp Ile Pro 
    210                 215                 220                 


Ala Leu Ser Val Gln Pro Gly Pro Lys Val Ala Ser Gly Glu Asn Val 
225                 230                 235                 240 


Thr Leu Leu Cys Gln Ser Trp His Gln Ile Asp Thr Phe Phe Leu Thr 
                245                 250                 255     


Lys Glu Gly Ala Ala His Pro Pro Leu Cys Leu Lys Ser Lys Tyr Gln 
            260                 265                 270         


Ser Tyr Arg His Gln Ala Glu Phe Ser Met Ser Pro Val Thr Ser Ala 
        275                 280                 285             


Gln Gly Gly Thr Tyr Arg Cys Tyr Ser Ala Ile Arg Ser Tyr Pro Tyr 
    290                 295                 300                 


Leu Leu Ser Ser Pro Ser Tyr Pro Gln Glu Leu Val Val Ser Gly Pro 
305                 310                 315                 320 


Ser Gly Asp Pro Ser Leu Ser Pro Thr Gly Ser Thr Pro Thr Pro Ala 
                325                 330                 335     


Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Leu Asp Pro Gln Ser 
            340                 345                 350         


Gly Leu Gly Arg His Leu Gly Val Val Thr Gly Val Ser Val Ala Phe 
        355                 360                 365             


Val Leu Leu Leu Phe Leu Leu Leu Phe Leu Leu Leu Arg His Arg His 
    370                 375                 380                 


Gln Ser Lys His Arg Thr Ser Ala His Phe Tyr Arg Pro Ala Gly Ala 
385                 390                 395                 400 


Ala Gly Pro Glu Pro Lys Asp Gln Gly Leu Gln Lys Arg Ala Ser Pro 
                405                 410                 415     


Val Ala Asp Ile Gln Glu Glu Ile Leu Asn Ala Ala Val Lys Asp Thr 
            420                 425                 430         


Gln Pro Lys Asp Gly Val Glu Met Asp Ala Arg Ala Ala Ala Ser Glu 
        435                 440                 445             


Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg 
    450                 455                 460                 


Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Arg Glu Pro Pro Ala 
465                 470                 475                 480 


Glu Pro Ser Ile Tyr Ala Pro Leu Ala Ile His 
                485                 490     


<210>  1048
<211>  632
<212>  PRT
<213>  Homo sapiens

<400>  1048

Met Thr Pro Ala Leu Thr Ala Leu Leu Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr Arg Met Gln Ala Gly Pro Phe Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Ser Trp Gly Ser Pro Val Thr Ile Trp 
        35                  40                  45              


Cys Gln Gly Ser Leu Glu Ala Gln Glu Tyr Gln Leu Asp Lys Glu Gly 
    50                  55                  60                  


Ser Pro Glu Pro Trp Asp Arg Asn Asn Pro Leu Glu Pro Lys Asn Lys 
65                  70                  75                  80  


Ala Arg Phe Ser Ile Pro Ser Met Thr Gln His His Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys His Tyr Tyr Ser Ser Ala Gly Trp Ser Glu Pro Ser Asp Pro 
            100                 105                 110         


Leu Glu Leu Val Met Thr Gly Phe Tyr Asn Lys Pro Thr Leu Ser Ala 
        115                 120                 125             


Leu Pro Ser Pro Val Val Ala Ser Gly Gly Asn Met Thr Leu Arg Cys 
    130                 135                 140                 


Gly Ser Gln Lys Gly Tyr His His Phe Val Leu Met Lys Glu Gly Glu 
145                 150                 155                 160 


His Gln Leu Pro Arg Thr Leu Asp Ser Gln Gln Leu His Ser Gly Gly 
                165                 170                 175     


Phe Gln Ala Leu Phe Pro Val Gly Pro Val Thr Pro Ser His Arg Trp 
            180                 185                 190         


Arg Phe Thr Cys Tyr Tyr Tyr Tyr Thr Asn Thr Pro Trp Val Trp Ser 
        195                 200                 205             


His Pro Ser Asp Pro Leu Glu Ile Leu Pro Ser Gly Val Ser Arg Lys 
    210                 215                 220                 


Pro Ser Leu Leu Thr Leu Gln Gly Pro Val Leu Ala Pro Gly Gln Ser 
225                 230                 235                 240 


Leu Thr Leu Gln Cys Gly Ser Asp Val Gly Tyr Asp Arg Phe Val Leu 
                245                 250                 255     


Tyr Lys Glu Gly Glu Arg Asp Phe Leu Gln Arg Pro Gly Gln Gln Pro 
            260                 265                 270         


Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg 
        275                 280                 285             


Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser 
    290                 295                 300                 


Glu Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln 
305                 310                 315                 320 


Ile Tyr Asp Thr Val Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Ala 
                325                 330                 335     


Ser Gly Glu Asn Met Thr Leu Leu Cys Gln Ser Arg Gly Tyr Phe Asp 
            340                 345                 350         


Thr Phe Leu Leu Thr Lys Glu Gly Ala Ala His Pro Pro Leu Arg Leu 
        355                 360                 365             


Arg Ser Met Tyr Gly Ala His Lys Tyr Gln Ala Glu Phe Pro Met Ser 
    370                 375                 380                 


Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Arg 
385                 390                 395                 400 


Ser Ser Asn Pro His Leu Leu Ser Phe Pro Ser Glu Pro Leu Glu Leu 
                405                 410                 415     


Met Val Ser Gly His Ser Gly Gly Ser Ser Leu Pro Pro Thr Gly Pro 
            420                 425                 430         


Pro Ser Thr Pro Gly Leu Gly Arg Tyr Leu Glu Val Leu Ile Gly Val 
        435                 440                 445             


Ser Val Ala Phe Val Leu Leu Leu Phe Leu Leu Leu Phe Leu Leu Leu 
    450                 455                 460                 


Leu Arg Gln Arg His Ser Lys His Arg Thr Ser Asp Gln Arg Lys Thr 
465                 470                 475                 480 


Asp Phe Gln Arg Pro Ala Gly Ala Ala Glu Thr Glu Pro Lys Asp Arg 
                485                 490                 495     


Gly Leu Leu Arg Arg Ser Ser Pro Ala Ala Asp Val Gln Glu Glu Asn 
            500                 505                 510         


Leu Tyr Ala Ala Val Lys Asp Thr Gln Ser Glu Asp Arg Val Glu Leu 
        515                 520                 525             


Asp Ser Gln Gln Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr 
    530                 535                 540                 


Ala Pro Val Lys His Ser Ser Pro Arg Arg Glu Met Ala Ser Pro Pro 
545                 550                 555                 560 


Ser Ser Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Val Glu 
                565                 570                 575     


Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Ser Gln 
            580                 585                 590         


Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Lys Ala 
        595                 600                 605             


Thr Glu Pro Pro Pro Ser Gln Glu Gly Glu Pro Pro Ala Glu Pro Ser 
    610                 615                 620                 


Ile Tyr Ala Thr Leu Ala Ile His 
625                 630         


<210>  1049
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  1049

Met Ile Asn Ser Thr Ser Thr Gln Pro Pro Asp Glu Ser Cys Ser Gln 
1               5                   10                  15      


Asn Leu Leu Ile Thr Gln Gln Ile Ile Pro Val Leu Tyr Cys Met Val 
            20                  25                  30          


Phe Ile Ala Gly Ile Leu Leu Asn Gly Val Ser Gly Trp Ile Phe Phe 
        35                  40                  45              


Tyr Val Pro Ser Ser Lys Ser Phe Ile Ile Tyr Leu Lys Asn Ile Val 
    50                  55                  60                  


Ile Ala Asp Phe Val Met Ser Leu Thr Phe Pro Phe Lys Ile Leu Gly 
65                  70                  75                  80  


Asp Ser Gly Leu Gly Pro Trp Gln Leu Asn Val Phe Val Cys Arg Val 
                85                  90                  95      


Ser Ala Val Leu Phe Tyr Val Asn Met Tyr Val Ser Ile Val Phe Phe 
            100                 105                 110         


Gly Leu Ile Ser Phe Asp Arg Tyr Tyr Lys Ile Val Lys Pro Leu Trp 
        115                 120                 125             


Thr Ser Phe Ile Gln Ser Val Ser Tyr Ser Lys Leu Leu Ser Val Ile 
    130                 135                 140                 


Val Trp Met Leu Met Leu Leu Leu Ala Val Pro Asn Ile Ile Leu Thr 
145                 150                 155                 160 


Asn Gln Ser Val Arg Glu Val Thr Gln Ile Lys Cys Ile Glu Leu Lys 
                165                 170                 175     


Ser Glu Leu Gly Arg Lys Trp His Lys Ala Ser Asn Tyr Ile Phe Val 
            180                 185                 190         


Ala Ile Phe Trp Ile Val Phe Leu Leu Leu Ile Val Phe Tyr Thr Ala 
        195                 200                 205             


Ile Thr Lys Lys Ile Phe Lys Ser His Leu Lys Ser Ser Arg Asn Ser 
    210                 215                 220                 


Thr Ser Val Lys Lys Lys Ser Ser Arg Asn Ile Phe Ser Ile Val Phe 
225                 230                 235                 240 


Val Phe Phe Val Cys Phe Val Pro Tyr His Ile Ala Arg Ile Pro Tyr 
                245                 250                 255     


Thr Lys Ser Gln Thr Glu Ala His Tyr Ser Cys Gln Ser Lys Glu Ile 
            260                 265                 270         


Leu Arg Tyr Met Lys Glu Phe Thr Leu Leu Leu Ser Ala Ala Asn Val 
        275                 280                 285             


Cys Leu Asp Pro Ile Ile Tyr Phe Phe Leu Cys Gln Pro Phe Arg Glu 
    290                 295                 300                 


Ile Leu Cys Lys Lys Leu His Ile Pro Leu Lys Ala Gln Asn Asp Leu 
305                 310                 315                 320 


Asp Ile Ser Arg Ile Lys Arg Gly Asn Thr Thr Leu Glu Ser Thr Asp 
                325                 330                 335     


Thr Leu 
        


<210>  1050
<211>  652
<212>  PRT
<213>  Homo sapiens

<400>  1050

Met Thr Pro Ile Leu Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Val Gln Ala Gly His Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Arg 
        35                  40                  45              


Cys Gln Gly Gly Gln Glu Thr Gln Glu Tyr Arg Leu Tyr Arg Glu Lys 
    50                  55                  60                  


Lys Thr Ala Pro Trp Ile Thr Arg Ile Pro Gln Glu Leu Val Lys Lys 
65                  70                  75                  80  


Gly Gln Phe Pro Ile Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr 
                85                  90                  95      


Arg Cys Tyr Tyr Gly Ser Asp Thr Ala Gly Arg Ser Glu Ser Ser Asp 
            100                 105                 110         


Pro Leu Glu Leu Val Val Thr Gly Ala Tyr Ile Lys Pro Thr Leu Ser 
        115                 120                 125             


Ala Gln Pro Ser Pro Val Val Asn Ser Gly Gly Asn Val Thr Leu Gln 
    130                 135                 140                 


Cys Asp Ser Gln Val Ala Phe Asp Gly Phe Ile Leu Cys Lys Glu Gly 
145                 150                 155                 160 


Glu Asp Glu His Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly 
                165                 170                 175     


Ser Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Ser Arg Arg 
            180                 185                 190         


Trp Trp Tyr Arg Cys Tyr Ala Tyr Asp Ser Asn Ser Pro Tyr Glu Trp 
        195                 200                 205             


Ser Leu Pro Ser Asp Leu Leu Glu Leu Leu Val Leu Gly Val Ser Lys 
    210                 215                 220                 


Lys Pro Ser Leu Ser Val Gln Pro Gly Pro Ile Val Ala Pro Glu Glu 
225                 230                 235                 240 


Thr Leu Thr Leu Gln Cys Gly Ser Asp Ala Gly Tyr Asn Arg Phe Val 
                245                 250                 255     


Leu Tyr Lys Asp Gly Glu Arg Asp Phe Leu Gln Leu Ala Gly Ala Gln 
            260                 265                 270         


Pro Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser 
        275                 280                 285             


Arg Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser 
    290                 295                 300                 


Ser Glu Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Ala Gly 
305                 310                 315                 320 


Gln Phe Tyr Asp Arg Val Ser Leu Ser Val Gln Pro Gly Pro Thr Val 
                325                 330                 335     


Ala Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Gln Gly Trp Met 
            340                 345                 350         


Gln Thr Phe Leu Leu Thr Lys Glu Gly Ala Ala Asp Asp Pro Trp Arg 
        355                 360                 365             


Leu Arg Ser Thr Tyr Gln Ser Gln Lys Tyr Gln Ala Glu Phe Pro Met 
    370                 375                 380                 


Gly Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser 
385                 390                 395                 400 


Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp Pro Leu Glu 
                405                 410                 415     


Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly 
            420                 425                 430         


Pro Thr Ser Thr Ser Ala Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr 
        435                 440                 445             


Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile 
    450                 455                 460                 


Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu Leu Leu 
465                 470                 475                 480 


Phe Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr 
                485                 490                 495     


Gln Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu 
            500                 505                 510         


Pro Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala 
        515                 520                 525             


Gln Glu Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp 
    530                 535                 540                 


Gly Val Glu Met Asp Thr Arg Gln Ser Pro His Asp Glu Asp Pro Gln 
545                 550                 555                 560 


Ala Val Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met 
                565                 570                 575     


Ala Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp 
            580                 585                 590         


Arg Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser 
        595                 600                 605             


Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu 
    610                 615                 620                 


Arg Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro 
625                 630                 635                 640 


Ala Val Pro Ser Ile Tyr Ala Thr Leu Ala Ile His 
                645                 650         


<210>  1051
<211>  651
<212>  PRT
<213>  Homo sapiens

<400>  1051

Met Thr Pro Ile Leu Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Val Gln Ala Gly His Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Arg 
        35                  40                  45              


Cys Gln Gly Gly Gln Glu Thr Gln Glu Tyr Arg Leu Tyr Arg Glu Lys 
    50                  55                  60                  


Lys Thr Ala Pro Trp Ile Thr Arg Ile Pro Gln Glu Leu Val Lys Lys 
65                  70                  75                  80  


Gly Gln Phe Pro Ile Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr 
                85                  90                  95      


Arg Cys Tyr Tyr Gly Ser Asp Thr Ala Gly Arg Ser Glu Ser Ser Asp 
            100                 105                 110         


Pro Leu Glu Leu Val Val Thr Gly Ala Tyr Ile Lys Pro Thr Leu Ser 
        115                 120                 125             


Ala Gln Pro Ser Pro Val Val Asn Ser Gly Gly Asn Val Thr Leu Gln 
    130                 135                 140                 


Cys Asp Ser Gln Val Ala Phe Asp Gly Phe Ile Leu Cys Lys Glu Gly 
145                 150                 155                 160 


Glu Asp Glu His Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly 
                165                 170                 175     


Ser Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Ser Arg Arg 
            180                 185                 190         


Trp Trp Tyr Arg Cys Tyr Ala Tyr Asp Ser Asn Ser Pro Tyr Glu Trp 
        195                 200                 205             


Ser Leu Pro Ser Asp Leu Leu Glu Leu Leu Val Leu Gly Val Ser Lys 
    210                 215                 220                 


Lys Pro Ser Leu Ser Val Gln Pro Gly Pro Ile Val Ala Pro Glu Glu 
225                 230                 235                 240 


Thr Leu Thr Leu Gln Cys Gly Ser Asp Ala Gly Tyr Asn Arg Phe Val 
                245                 250                 255     


Leu Tyr Lys Asp Gly Glu Arg Asp Phe Leu Gln Leu Ala Gly Ala Gln 
            260                 265                 270         


Pro Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser 
        275                 280                 285             


Arg Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser 
    290                 295                 300                 


Ser Glu Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Ala Gly 
305                 310                 315                 320 


Gln Phe Tyr Asp Arg Val Ser Leu Ser Val Gln Pro Gly Pro Thr Val 
                325                 330                 335     


Ala Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Gln Gly Trp Met 
            340                 345                 350         


Gln Thr Phe Leu Leu Thr Lys Glu Gly Ala Ala Asp Asp Pro Trp Arg 
        355                 360                 365             


Leu Arg Ser Thr Tyr Gln Ser Gln Lys Tyr Gln Ala Glu Phe Pro Met 
    370                 375                 380                 


Gly Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser 
385                 390                 395                 400 


Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp Pro Leu Glu 
                405                 410                 415     


Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly 
            420                 425                 430         


Pro Thr Ser Thr Ser Ala Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr 
        435                 440                 445             


Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile 
    450                 455                 460                 


Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu Leu Leu 
465                 470                 475                 480 


Phe Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr 
                485                 490                 495     


Gln Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu 
            500                 505                 510         


Pro Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala 
        515                 520                 525             


Gln Glu Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp 
    530                 535                 540                 


Gly Val Glu Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala 
545                 550                 555                 560 


Val Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala 
                565                 570                 575     


Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg 
            580                 585                 590         


Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu 
        595                 600                 605             


Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg 
    610                 615                 620                 


Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala 
625                 630                 635                 640 


Val Pro Ser Ile Tyr Ala Thr Leu Ala Ile His 
                645                 650     


<210>  1052
<211>  651
<212>  PRT
<213>  Homo sapiens

<400>  1052

Met Thr Pro Ile Leu Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Val Gln Ala Gly His Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Arg 
        35                  40                  45              


Cys Gln Gly Gly Gln Glu Thr Gln Glu Tyr Arg Leu Tyr Arg Glu Lys 
    50                  55                  60                  


Lys Thr Ala Pro Trp Ile Thr Arg Ile Pro Gln Glu Leu Val Lys Lys 
65                  70                  75                  80  


Gly Gln Phe Pro Ile Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr 
                85                  90                  95      


Arg Cys Tyr Tyr Gly Ser Asp Thr Ala Gly Arg Ser Glu Ser Ser Asp 
            100                 105                 110         


Pro Leu Glu Leu Val Val Thr Gly Ala Tyr Ile Lys Pro Thr Leu Ser 
        115                 120                 125             


Ala Gln Pro Ser Pro Val Val Asn Ser Gly Gly Asn Val Thr Leu Gln 
    130                 135                 140                 


Cys Asp Ser Gln Val Ala Phe Asp Gly Phe Ile Leu Cys Lys Glu Gly 
145                 150                 155                 160 


Glu Asp Glu His Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly 
                165                 170                 175     


Ser Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Ser Arg Arg 
            180                 185                 190         


Trp Trp Tyr Arg Cys Tyr Ala Tyr Asp Ser Asn Ser Pro Tyr Glu Trp 
        195                 200                 205             


Ser Leu Pro Ser Asp Leu Leu Glu Leu Leu Val Leu Gly Val Ser Lys 
    210                 215                 220                 


Lys Pro Ser Leu Ser Val Gln Pro Gly Pro Ile Val Ala Pro Glu Glu 
225                 230                 235                 240 


Thr Leu Thr Leu Gln Cys Gly Ser Asp Ala Gly Tyr Asn Arg Phe Val 
                245                 250                 255     


Leu Tyr Lys Asp Gly Glu Arg Asp Phe Leu Gln Leu Ala Gly Ala Gln 
            260                 265                 270         


Pro Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser 
        275                 280                 285             


Arg Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser 
    290                 295                 300                 


Ser Glu Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Ala Gly 
305                 310                 315                 320 


Gln Phe Tyr Asp Arg Val Ser Leu Ser Val Gln Pro Gly Pro Thr Val 
                325                 330                 335     


Ala Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Gln Gly Trp Met 
            340                 345                 350         


Gln Thr Phe Leu Leu Thr Lys Glu Gly Ala Ala Asp Asp Pro Trp Arg 
        355                 360                 365             


Leu Arg Ser Thr Tyr Gln Ser Gln Lys Tyr Gln Ala Glu Phe Pro Met 
    370                 375                 380                 


Gly Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser 
385                 390                 395                 400 


Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp Pro Leu Glu 
                405                 410                 415     


Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly 
            420                 425                 430         


Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly 
        435                 440                 445             


Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly 
    450                 455                 460                 


Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe 
465                 470                 475                 480 


Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln 
                485                 490                 495     


Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro 
            500                 505                 510         


Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln 
        515                 520                 525             


Glu Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly 
    530                 535                 540                 


Val Glu Met Asp Thr Arg Gln Ser Pro His Asp Glu Asp Pro Gln Ala 
545                 550                 555                 560 


Val Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala 
                565                 570                 575     


Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg 
            580                 585                 590         


Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu 
        595                 600                 605             


Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg 
    610                 615                 620                 


Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala 
625                 630                 635                 640 


Val Pro Ser Ile Tyr Ala Thr Leu Ala Ile His 
                645                 650     


<210>  1053
<211>  1951
<212>  PRT
<213>  Homo sapiens

<400>  1053

Met Ala Gln Ala Leu Leu Val Pro Pro Gly Pro Glu Ser Phe Arg Leu 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Ala Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Lys Pro Lys Lys Glu Gln Asp Asn Asp Asp Glu Asn Lys 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Met Asn Lys Gly 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Leu Asn Pro Val Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Leu Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Ser Val Ile Val Met Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Ser Asp Ser Ala Phe Glu 
        275                 280                 285             


Thr Asn Thr Thr Ser Tyr Phe Asn Gly Thr Met Asp Ser Asn Gly Thr 
    290                 295                 300                 


Phe Val Asn Val Thr Met Ser Thr Phe Asn Trp Lys Asp Tyr Ile Gly 
305                 310                 315                 320 


Asp Asp Ser His Phe Tyr Val Leu Asp Gly Gln Lys Asp Pro Leu Leu 
                325                 330                 335     


Cys Gly Asn Gly Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile Cys 
            340                 345                 350         


Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr 
        355                 360                 365             


Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Tyr 
    370                 375                 380                 


Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr 
385                 390                 395                 400 


Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Val 
                405                 410                 415     


Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln 
            420                 425                 430         


Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met 
        435                 440                 445             


Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Val Ala Ala 
    450                 455                 460                 


Ala Ser Ala Ala Ser Arg Asp Phe Ser Gly Ile Gly Gly Leu Gly Glu 
465                 470                 475                 480 


Leu Leu Glu Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala 
                485                 490                 495     


Lys Glu Trp Arg Asn Arg Arg Lys Lys Arg Arg Gln Arg Glu His Leu 
            500                 505                 510         


Glu Gly Asn Asn Lys Gly Glu Arg Asp Ser Phe Pro Lys Ser Glu Ser 
        515                 520                 525             


Glu Asp Ser Val Lys Arg Ser Ser Phe Leu Phe Ser Met Asp Gly Asn 
    530                 535                 540                 


Arg Leu Thr Ser Asp Lys Lys Phe Cys Ser Pro His Gln Ser Leu Leu 
545                 550                 555                 560 


Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Lys Thr Ser 
                565                 570                 575     


Ile Phe Ser Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp 
            580                 585                 590         


Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Ser Glu Ser Arg Arg 
        595                 600                 605             


Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg Asn Ser Asn 
    610                 615                 620                 


Gly Thr Thr Thr Glu Thr Glu Val Arg Lys Arg Arg Leu Ser Ser Tyr 
625                 630                 635                 640 


Gln Ile Ser Met Glu Met Leu Glu Asp Ser Ser Gly Arg Gln Arg Ala 
                645                 650                 655     


Val Ser Ile Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu Glu 
            660                 665                 670         


Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Arg Phe Ala Asn Val Phe 
        675                 680                 685             


Leu Ile Trp Asp Cys Cys Asp Ala Trp Leu Lys Val Lys His Leu Val 
    690                 695                 700                 


Asn Leu Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
705                 710                 715                 720 


Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met Thr 
                725                 730                 735     


Glu Gln Phe Ser Ser Val Leu Thr Val Gly Asn Leu Val Phe Thr Gly 
            740                 745                 750         


Ile Phe Thr Ala Glu Met Val Leu Lys Ile Ile Ala Met Asp Pro Tyr 
        755                 760                 765             


Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Ile Ile Val Ser 
    770                 775                 780                 


Leu Ser Leu Met Glu Leu Gly Leu Ser Asn Val Glu Gly Leu Ser Val 
785                 790                 795                 800 


Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
                805                 810                 815     


Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
            820                 825                 830         


Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 
        835                 840                 845             


Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys 
    850                 855                 860                 


Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg Trp His Met Asn Asp Phe 
865                 870                 875                 880 


Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile 
                885                 890                 895     


Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys Leu 
            900                 905                 910         


Ile Val Phe Met Leu Val Met Val Ile Gly Asn Leu Val Val Leu Asn 
        915                 920                 925             


Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Ala 
    930                 935                 940                 


Ala Thr Asp Asp Asp Asn Glu Met Asn Asn Leu Gln Ile Ala Val Gly 
945                 950                 955                 960 


Arg Met Gln Lys Gly Ile Asp Tyr Val Lys Asn Lys Met Arg Glu Cys 
                965                 970                 975     


Phe Gln Lys Ala Phe Phe Arg Lys Pro Lys Val Ile Glu Ile His Glu 
            980                 985                 990         


Gly Asn Lys Ile Asp Ser Cys Met  Ser Asn Asn Thr Gly  Ile Glu Ile 
        995                 1000                 1005             


Ser Lys  Glu Leu Asn Tyr Leu  Arg Asp Gly Asn Gly  Thr Thr Ser 
    1010                 1015                 1020             


Gly Val  Gly Thr Gly Ser Ser  Val Glu Lys Tyr Val  Ile Asp Glu 
    1025                 1030                 1035             


Asn Asp  Tyr Met Ser Phe Ile  Asn Asn Pro Ser Leu  Thr Val Thr 
    1040                 1045                 1050             


Val Pro  Ile Ala Val Gly Glu  Ser Asp Phe Glu Asn  Leu Asn Thr 
    1055                 1060                 1065             


Glu Glu  Phe Ser Ser Glu Ser  Glu Leu Glu Glu Ser  Lys Glu Lys 
    1070                 1075                 1080             


Leu Asn  Ala Thr Ser Ser Ser  Glu Gly Ser Thr Val  Asp Val Val 
    1085                 1090                 1095             


Leu Pro  Arg Glu Gly Glu Gln  Ala Glu Thr Glu Pro  Glu Glu Asp 
    1100                 1105                 1110             


Leu Lys  Pro Glu Ala Cys Phe  Thr Glu Gly Cys Ile  Lys Lys Phe 
    1115                 1120                 1125             


Pro Phe  Cys Gln Val Ser Thr  Glu Glu Gly Lys Gly  Lys Ile Trp 
    1130                 1135                 1140             


Trp Asn  Leu Arg Lys Thr Cys  Tyr Ser Ile Val Glu  His Asn Trp 
    1145                 1150                 1155             


Phe Glu  Thr Phe Ile Val Phe  Met Ile Leu Leu Ser  Ser Gly Ala 
    1160                 1165                 1170             


Leu Ala  Phe Glu Asp Ile Tyr  Ile Glu Gln Arg Lys  Thr Ile Lys 
    1175                 1180                 1185             


Thr Met  Leu Glu Tyr Ala Asp  Lys Val Phe Thr Tyr  Ile Phe Ile 
    1190                 1195                 1200             


Leu Glu  Met Leu Leu Lys Trp  Val Ala Tyr Gly Phe  Gln Thr Tyr 
    1205                 1210                 1215             


Phe Thr  Asn Ala Trp Cys Trp  Leu Asp Phe Leu Ile  Val Asp Val 
    1220                 1225                 1230             


Ser Leu  Val Ser Leu Val Ala  Asn Ala Leu Gly Tyr  Ser Glu Leu 
    1235                 1240                 1245             


Gly Ala  Ile Lys Ser Leu Arg  Thr Leu Arg Ala Leu  Arg Pro Leu 
    1250                 1255                 1260             


Arg Ala  Leu Ser Arg Phe Glu  Gly Met Arg Val Val  Val Asn Ala 
    1265                 1270                 1275             


Leu Val  Gly Ala Ile Pro Ser  Ile Met Asn Val Leu  Leu Val Cys 
    1280                 1285                 1290             


Leu Ile  Phe Trp Leu Ile Phe  Ser Ile Met Gly Val  Asn Leu Phe 
    1295                 1300                 1305             


Ala Gly  Lys Phe Tyr His Cys  Val Asn Met Thr Thr  Gly Asn Met 
    1310                 1315                 1320             


Phe Asp  Ile Ser Asp Val Asn  Asn Leu Ser Asp Cys  Gln Ala Leu 
    1325                 1330                 1335             


Gly Lys  Gln Ala Arg Trp Lys  Asn Val Lys Val Asn  Phe Asp Asn 
    1340                 1345                 1350             


Val Gly  Ala Gly Tyr Leu Ala  Leu Leu Gln Val Ala  Thr Phe Lys 
    1355                 1360                 1365             


Gly Trp  Met Asp Ile Met Tyr  Ala Ala Val Asp Ser  Arg Asp Val 
    1370                 1375                 1380             


Lys Leu  Gln Pro Val Tyr Glu  Glu Asn Leu Tyr Met  Tyr Leu Tyr 
    1385                 1390                 1395             


Phe Val  Ile Phe Ile Ile Phe  Gly Ser Phe Phe Thr  Leu Asn Leu 
    1400                 1405                 1410             


Phe Ile  Gly Val Ile Ile Asp  Asn Phe Asn Gln Gln  Lys Lys Lys 
    1415                 1420                 1425             


Phe Gly  Gly Gln Asp Ile Phe  Met Thr Glu Glu Gln  Lys Lys Tyr 
    1430                 1435                 1440             


Tyr Asn  Ala Met Lys Lys Leu  Gly Ser Lys Lys Pro  Gln Lys Pro 
    1445                 1450                 1455             


Ile Pro  Arg Pro Ala Asn Lys  Phe Gln Gly Met Val  Phe Asp Phe 
    1460                 1465                 1470             


Val Thr  Arg Gln Val Phe Asp  Ile Ser Ile Met Ile  Leu Ile Cys 
    1475                 1480                 1485             


Leu Asn  Met Val Thr Met Met  Val Glu Thr Asp Asp  Gln Gly Lys 
    1490                 1495                 1500             


Tyr Met  Thr Leu Val Leu Ser  Arg Ile Asn Leu Val  Phe Ile Val 
    1505                 1510                 1515             


Leu Phe  Thr Gly Glu Phe Val  Leu Lys Leu Val Ser  Leu Arg His 
    1520                 1525                 1530             


Tyr Tyr  Phe Thr Ile Gly Trp  Asn Ile Phe Asp Phe  Val Val Val 
    1535                 1540                 1545             


Ile Leu  Ser Ile Val Gly Met  Phe Leu Ala Glu Met  Ile Glu Lys 
    1550                 1555                 1560             


Tyr Phe  Val Ser Pro Thr Leu  Phe Arg Val Ile Arg  Leu Ala Arg 
    1565                 1570                 1575             


Ile Gly  Arg Ile Leu Arg Leu  Ile Lys Gly Ala Lys  Gly Ile Arg 
    1580                 1585                 1590             


Thr Leu  Leu Phe Ala Leu Met  Met Ser Leu Pro Ala  Leu Phe Asn 
    1595                 1600                 1605             


Ile Gly  Leu Leu Leu Phe Leu  Val Met Phe Ile Tyr  Ala Ile Phe 
    1610                 1615                 1620             


Gly Met  Ser Asn Phe Ala Tyr  Val Lys Lys Glu Ala  Gly Ile Asp 
    1625                 1630                 1635             


Asp Met  Phe Asn Phe Glu Thr  Phe Gly Asn Ser Met  Ile Cys Leu 
    1640                 1645                 1650             


Phe Gln  Ile Thr Thr Ser Ala  Gly Trp Asp Gly Leu  Leu Ala Pro 
    1655                 1660                 1665             


Ile Leu  Asn Ser Ala Pro Pro  Asp Cys Asp Pro Asp  Thr Ile His 
    1670                 1675                 1680             


Pro Gly  Ser Ser Val Lys Gly  Asp Cys Gly Asn Pro  Ser Val Gly 
    1685                 1690                 1695             


Ile Phe  Phe Phe Val Ser Tyr  Ile Ile Ile Ser Phe  Leu Val Val 
    1700                 1705                 1710             


Val Asn  Met Tyr Ile Ala Val  Ile Leu Glu Asn Phe  Ser Val Ala 
    1715                 1720                 1725             


Thr Glu  Glu Ser Ala Glu Pro  Leu Ser Glu Asp Asp  Phe Glu Met 
    1730                 1735                 1740             


Phe Tyr  Glu Val Trp Glu Lys  Phe Asp Pro Asp Ala  Thr Gln Phe 
    1745                 1750                 1755             


Ile Glu  Phe Ser Lys Leu Ser  Asp Phe Ala Ala Ala  Leu Asp Pro 
    1760                 1765                 1770             


Pro Leu  Leu Ile Ala Lys Pro  Asn Lys Val Gln Leu  Ile Ala Met 
    1775                 1780                 1785             


Asp Leu  Pro Met Val Ser Gly  Asp Arg Ile His Cys  Leu Asp Ile 
    1790                 1795                 1800             


Leu Phe  Ala Phe Thr Lys Arg  Val Leu Gly Glu Ser  Gly Glu Met 
    1805                 1810                 1815             


Asp Ala  Leu Arg Ile Gln Met  Glu Asp Arg Phe Met  Ala Ser Asn 
    1820                 1825                 1830             


Pro Ser  Lys Val Ser Tyr Glu  Pro Ile Thr Thr Thr  Leu Lys Arg 
    1835                 1840                 1845             


Lys Gln  Glu Glu Val Ser Ala  Ala Ile Ile Gln Arg  Asn Phe Arg 
    1850                 1855                 1860             


Cys Tyr  Leu Leu Lys Gln Arg  Leu Lys Asn Ile Ser  Ser Asn Tyr 
    1865                 1870                 1875             


Asn Lys  Glu Ala Ile Lys Gly  Arg Ile Asp Leu Pro  Ile Lys Gln 
    1880                 1885                 1890             


Asp Met  Ile Ile Asp Lys Leu  Asn Gly Asn Ser Thr  Pro Glu Lys 
    1895                 1900                 1905             


Thr Asp  Gly Ser Ser Ser Thr  Thr Ser Pro Pro Ser  Tyr Asp Ser 
    1910                 1915                 1920             


Val Thr  Lys Pro Asp Lys Glu  Lys Phe Glu Lys Asp  Lys Pro Glu 
    1925                 1930                 1935             


Lys Glu  Ser Lys Gly Lys Glu  Val Arg Glu Asn Gln  Lys 
    1940                 1945                 1950     


<210>  1054
<211>  1951
<212>  PRT
<213>  Homo sapiens

<400>  1054

Met Ala Gln Ala Leu Leu Val Pro Pro Gly Pro Glu Ser Phe Arg Leu 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Ala Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Lys Pro Lys Lys Glu Gln Asp Asn Asp Asp Glu Asn Lys 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Met Asn Lys Gly 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Leu Asn Pro Val Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Leu Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Ser Val Ile Val Met Ala Tyr Val Thr Glu Phe Val Ser 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Ser Asp Ser Ala Phe Glu 
        275                 280                 285             


Thr Asn Thr Thr Ser Tyr Phe Asn Gly Thr Met Asp Ser Asn Gly Thr 
    290                 295                 300                 


Phe Val Asn Val Thr Met Ser Thr Phe Asn Trp Lys Asp Tyr Ile Gly 
305                 310                 315                 320 


Asp Asp Ser His Phe Tyr Val Leu Asp Gly Gln Lys Asp Pro Leu Leu 
                325                 330                 335     


Cys Gly Asn Gly Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile Cys 
            340                 345                 350         


Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr 
        355                 360                 365             


Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Tyr 
    370                 375                 380                 


Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr 
385                 390                 395                 400 


Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Val 
                405                 410                 415     


Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln 
            420                 425                 430         


Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met 
        435                 440                 445             


Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Val Ala Ala 
    450                 455                 460                 


Ala Ser Ala Ala Ser Arg Asp Phe Ser Gly Ile Gly Gly Leu Gly Glu 
465                 470                 475                 480 


Leu Leu Glu Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala 
                485                 490                 495     


Lys Glu Trp Arg Asn Arg Arg Lys Lys Arg Arg Gln Arg Glu His Leu 
            500                 505                 510         


Glu Gly Asn Asn Lys Gly Glu Arg Asp Ser Phe Pro Lys Ser Glu Ser 
        515                 520                 525             


Glu Asp Ser Val Lys Arg Ser Ser Phe Leu Phe Ser Met Asp Gly Asn 
    530                 535                 540                 


Arg Leu Thr Ser Asp Lys Lys Phe Cys Ser Pro His Gln Ser Leu Leu 
545                 550                 555                 560 


Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Lys Thr Ser 
                565                 570                 575     


Ile Phe Ser Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp 
            580                 585                 590         


Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Ser Glu Ser Arg Arg 
        595                 600                 605             


Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg Asn Ser Asn 
    610                 615                 620                 


Gly Thr Thr Thr Glu Thr Glu Val Arg Lys Arg Arg Leu Ser Ser Tyr 
625                 630                 635                 640 


Gln Ile Ser Met Glu Met Leu Glu Asp Ser Ser Gly Arg Gln Arg Ala 
                645                 650                 655     


Val Ser Ile Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu Glu 
            660                 665                 670         


Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Arg Phe Ala Asn Val Phe 
        675                 680                 685             


Leu Ile Trp Asp Cys Cys Asp Ala Trp Leu Lys Val Lys His Leu Val 
    690                 695                 700                 


Asn Leu Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
705                 710                 715                 720 


Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met Thr 
                725                 730                 735     


Glu Gln Phe Ser Ser Val Leu Thr Val Gly Asn Leu Val Phe Thr Gly 
            740                 745                 750         


Ile Phe Thr Ala Glu Met Val Leu Lys Ile Ile Ala Met Asp Pro Tyr 
        755                 760                 765             


Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Ile Ile Val Ser 
    770                 775                 780                 


Leu Ser Leu Met Glu Leu Gly Leu Ser Asn Val Glu Gly Leu Ser Val 
785                 790                 795                 800 


Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
                805                 810                 815     


Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
            820                 825                 830         


Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 
        835                 840                 845             


Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys 
    850                 855                 860                 


Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg Trp His Met Asn Asp Phe 
865                 870                 875                 880 


Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile 
                885                 890                 895     


Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys Leu 
            900                 905                 910         


Ile Val Phe Met Leu Val Met Val Ile Gly Asn Leu Val Val Leu Asn 
        915                 920                 925             


Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Ala 
    930                 935                 940                 


Ala Thr Asp Asp Asp Asn Glu Met Asn Asn Leu Gln Ile Ala Val Gly 
945                 950                 955                 960 


Arg Met Gln Lys Gly Ile Asp Tyr Val Lys Asn Lys Met Arg Glu Cys 
                965                 970                 975     


Phe Gln Lys Ala Phe Phe Arg Lys Pro Lys Val Ile Glu Ile His Glu 
            980                 985                 990         


Gly Asn Lys Ile Asp Ser Cys Met  Ser Asn Asn Thr Gly  Ile Glu Ile 
        995                 1000                 1005             


Ser Lys  Glu Leu Asn Tyr Leu  Arg Asp Gly Asn Gly  Thr Thr Ser 
    1010                 1015                 1020             


Gly Val  Gly Thr Gly Ser Ser  Val Glu Lys Tyr Val  Ile Asp Glu 
    1025                 1030                 1035             


Asn Asp  Tyr Met Ser Phe Ile  Asn Asn Pro Ser Leu  Thr Val Thr 
    1040                 1045                 1050             


Val Pro  Ile Ala Val Gly Glu  Ser Asp Phe Glu Asn  Leu Asn Thr 
    1055                 1060                 1065             


Glu Glu  Phe Ser Ser Glu Ser  Glu Leu Glu Glu Ser  Lys Glu Lys 
    1070                 1075                 1080             


Leu Asn  Ala Thr Ser Ser Ser  Glu Gly Ser Thr Val  Asp Val Val 
    1085                 1090                 1095             


Leu Pro  Arg Glu Gly Glu Gln  Ala Glu Thr Glu Pro  Glu Glu Asp 
    1100                 1105                 1110             


Leu Lys  Pro Glu Ala Cys Phe  Thr Glu Gly Cys Ile  Lys Lys Phe 
    1115                 1120                 1125             


Pro Phe  Cys Gln Val Ser Thr  Glu Glu Gly Lys Gly  Lys Ile Trp 
    1130                 1135                 1140             


Trp Asn  Leu Arg Lys Thr Cys  Tyr Ser Ile Val Glu  His Asn Trp 
    1145                 1150                 1155             


Phe Glu  Thr Phe Ile Val Phe  Met Ile Leu Leu Ser  Ser Gly Ala 
    1160                 1165                 1170             


Leu Ala  Phe Glu Asp Ile Tyr  Ile Glu Gln Arg Lys  Thr Ile Lys 
    1175                 1180                 1185             


Thr Met  Leu Glu Tyr Ala Asp  Lys Val Phe Thr Tyr  Ile Phe Ile 
    1190                 1195                 1200             


Leu Glu  Met Leu Leu Lys Trp  Val Ala Tyr Gly Phe  Gln Thr Tyr 
    1205                 1210                 1215             


Phe Thr  Asn Ala Trp Cys Trp  Leu Asp Phe Leu Ile  Val Asp Val 
    1220                 1225                 1230             


Ser Leu  Val Ser Leu Val Ala  Asn Ala Leu Gly Tyr  Ser Glu Leu 
    1235                 1240                 1245             


Gly Ala  Ile Lys Ser Leu Arg  Thr Leu Arg Ala Leu  Arg Pro Leu 
    1250                 1255                 1260             


Arg Ala  Leu Ser Arg Phe Glu  Gly Met Arg Val Val  Val Asn Ala 
    1265                 1270                 1275             


Leu Val  Gly Ala Ile Pro Ser  Ile Met Asn Val Leu  Leu Val Cys 
    1280                 1285                 1290             


Leu Ile  Phe Trp Leu Ile Phe  Ser Ile Met Gly Val  Asn Leu Phe 
    1295                 1300                 1305             


Ala Gly  Lys Phe Tyr His Cys  Val Asn Met Thr Thr  Gly Asn Met 
    1310                 1315                 1320             


Phe Asp  Ile Ser Asp Val Asn  Asn Leu Ser Asp Cys  Gln Ala Leu 
    1325                 1330                 1335             


Gly Lys  Gln Ala Arg Trp Lys  Asn Val Lys Val Asn  Phe Asp Asn 
    1340                 1345                 1350             


Val Gly  Ala Gly Tyr Leu Ala  Leu Leu Gln Val Ala  Thr Phe Lys 
    1355                 1360                 1365             


Gly Trp  Met Asp Ile Met Tyr  Ala Ala Val Asp Ser  Arg Asp Val 
    1370                 1375                 1380             


Lys Leu  Gln Pro Val Tyr Glu  Glu Asn Leu Tyr Met  Tyr Leu Tyr 
    1385                 1390                 1395             


Phe Val  Ile Phe Ile Ile Phe  Gly Ser Phe Phe Thr  Leu Asn Leu 
    1400                 1405                 1410             


Phe Ile  Gly Val Ile Ile Asp  Asn Phe Asn Gln Gln  Lys Lys Lys 
    1415                 1420                 1425             


Phe Gly  Gly Gln Asp Ile Phe  Met Thr Glu Glu Gln  Lys Lys Tyr 
    1430                 1435                 1440             


Tyr Asn  Ala Met Lys Lys Leu  Gly Ser Lys Lys Pro  Gln Lys Pro 
    1445                 1450                 1455             


Ile Pro  Arg Pro Ala Asn Lys  Phe Gln Gly Met Val  Phe Asp Phe 
    1460                 1465                 1470             


Val Thr  Arg Gln Val Phe Asp  Ile Ser Ile Met Ile  Leu Ile Cys 
    1475                 1480                 1485             


Leu Asn  Met Val Thr Met Met  Val Glu Thr Asp Asp  Gln Gly Lys 
    1490                 1495                 1500             


Tyr Met  Thr Leu Val Leu Ser  Arg Ile Asn Leu Val  Phe Ile Val 
    1505                 1510                 1515             


Leu Phe  Thr Gly Glu Phe Val  Leu Lys Leu Val Ser  Leu Arg His 
    1520                 1525                 1530             


Tyr Tyr  Phe Thr Ile Gly Trp  Asn Ile Phe Asp Phe  Val Val Val 
    1535                 1540                 1545             


Ile Leu  Ser Ile Val Gly Met  Phe Leu Ala Glu Met  Ile Glu Lys 
    1550                 1555                 1560             


Tyr Phe  Val Ser Pro Thr Leu  Phe Arg Val Ile Arg  Leu Ala Arg 
    1565                 1570                 1575             


Ile Gly  Arg Ile Leu Arg Leu  Ile Lys Gly Ala Lys  Gly Ile Arg 
    1580                 1585                 1590             


Thr Leu  Leu Phe Ala Leu Met  Met Ser Leu Pro Ala  Leu Phe Asn 
    1595                 1600                 1605             


Ile Gly  Leu Leu Leu Phe Leu  Val Met Phe Ile Tyr  Ala Ile Phe 
    1610                 1615                 1620             


Gly Met  Ser Asn Phe Ala Tyr  Val Lys Lys Glu Ala  Gly Ile Asp 
    1625                 1630                 1635             


Asp Met  Phe Asn Phe Glu Thr  Phe Gly Asn Ser Met  Ile Cys Leu 
    1640                 1645                 1650             


Phe Gln  Ile Thr Thr Ser Ala  Gly Trp Asp Gly Leu  Leu Ala Pro 
    1655                 1660                 1665             


Ile Leu  Asn Ser Ala Pro Pro  Asp Cys Asp Pro Asp  Thr Ile His 
    1670                 1675                 1680             


Pro Gly  Ser Ser Val Lys Gly  Asp Cys Gly Asn Pro  Ser Val Gly 
    1685                 1690                 1695             


Ile Phe  Phe Phe Val Ser Tyr  Ile Ile Ile Ser Phe  Leu Val Val 
    1700                 1705                 1710             


Val Asn  Met Tyr Ile Ala Val  Ile Leu Glu Asn Phe  Ser Val Ala 
    1715                 1720                 1725             


Thr Glu  Glu Ser Ala Glu Pro  Leu Ser Glu Asp Asp  Phe Glu Met 
    1730                 1735                 1740             


Phe Tyr  Glu Val Trp Glu Lys  Phe Asp Pro Asp Ala  Thr Gln Phe 
    1745                 1750                 1755             


Ile Glu  Phe Ser Lys Leu Ser  Asp Phe Ala Ala Ala  Leu Asp Pro 
    1760                 1765                 1770             


Pro Leu  Leu Ile Ala Lys Pro  Asn Lys Val Gln Leu  Ile Ala Met 
    1775                 1780                 1785             


Asp Leu  Pro Met Val Ser Gly  Asp Arg Ile His Cys  Leu Asp Ile 
    1790                 1795                 1800             


Leu Phe  Ala Phe Thr Lys Arg  Val Leu Gly Glu Ser  Gly Glu Met 
    1805                 1810                 1815             


Asp Ala  Leu Arg Ile Gln Met  Glu Asp Arg Phe Met  Ala Ser Asn 
    1820                 1825                 1830             


Pro Ser  Lys Val Ser Tyr Glu  Pro Ile Thr Thr Thr  Leu Lys Arg 
    1835                 1840                 1845             


Lys Gln  Glu Glu Val Ser Ala  Ala Ile Ile Gln Arg  Asn Phe Arg 
    1850                 1855                 1860             


Cys Tyr  Leu Leu Lys Gln Arg  Leu Lys Asn Ile Ser  Ser Asn Tyr 
    1865                 1870                 1875             


Asn Lys  Glu Ala Ile Lys Gly  Arg Ile Asp Leu Pro  Ile Lys Gln 
    1880                 1885                 1890             


Asp Met  Ile Ile Asp Lys Leu  Asn Gly Asn Ser Thr  Pro Glu Lys 
    1895                 1900                 1905             


Thr Asp  Gly Ser Ser Ser Thr  Thr Ser Pro Pro Ser  Tyr Asp Ser 
    1910                 1915                 1920             


Val Thr  Lys Pro Asp Lys Glu  Lys Phe Glu Lys Asp  Lys Pro Glu 
    1925                 1930                 1935             


Lys Glu  Ser Lys Gly Lys Glu  Val Arg Glu Asn Gln  Lys 
    1940                 1945                 1950     


<210>  1055
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  1055

Met Asp Phe Leu His Arg Asn Gly Val Leu Ile Ile Gln His Leu Gln 
1               5                   10                  15      


Lys Asp Tyr Arg Ala Tyr Tyr Thr Phe Leu Asn Phe Met Ser Asn Val 
            20                  25                  30          


Gly Asp Pro Arg Asn Ile Phe Phe Ile Tyr Phe Pro Leu Cys Phe Gln 
        35                  40                  45              


Phe Asn Gln Thr Val Gly Thr Lys Met Ile Trp Val Ala Val Ile Gly 
    50                  55                  60                  


Asp Trp Leu Asn Leu Ile Phe Lys Trp Ile Leu Phe Gly His Arg Pro 
65                  70                  75                  80  


Tyr Trp Trp Val Gln Glu Thr Gln Ile Tyr Pro Asn His Ser Ser Pro 
                85                  90                  95      


Cys Leu Glu Gln Phe Pro Thr Thr Cys Glu Thr Gly Pro Gly Ser Pro 
            100                 105                 110         


Ser Gly His Ala Met Gly Ala Ser Cys Val Trp Tyr Val Met Val Thr 
        115                 120                 125             


Ala Ala Leu Ser His Thr Val Cys Gly Met Asp Lys Phe Ser Ile Thr 
    130                 135                 140                 


Leu His Arg His Ala Gly Gly Arg Gly Leu 
145                 150                 


<210>  1056
<211>  677
<212>  PRT
<213>  Homo sapiens

<400>  1056

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30          


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Ala Leu Gly Pro 
        35                  40                  45              


Gly Gly Lys Pro Leu Lys Pro Val Pro Gly Gly Leu Ala Gly Ala Gly 
    50                  55                  60                  


Leu Gly Ala Gly Leu Gly Ala Phe Pro Ala Val Thr Phe Pro Gly Ala 
65                  70                  75                  80  


Leu Val Pro Gly Gly Val Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala 
                85                  90                  95      


Lys Ala Gly Ala Gly Leu Gly Gly Val Pro Gly Val Gly Gly Leu Gly 
            100                 105                 110         


Val Ser Ala Gly Ala Val Val Pro Gln Pro Gly Ala Gly Val Lys Pro 
        115                 120                 125             


Gly Lys Val Pro Gly Val Gly Leu Pro Gly Val Tyr Pro Gly Gly Val 
    130                 135                 140                 


Leu Pro Gly Ala Arg Phe Pro Gly Val Gly Val Leu Pro Gly Val Pro 
145                 150                 155                 160 


Thr Gly Ala Gly Val Lys Pro Lys Ala Pro Gly Val Gly Gly Ala Phe 
                165                 170                 175     


Ala Gly Ile Pro Gly Val Gly Pro Phe Gly Gly Pro Gln Pro Gly Val 
            180                 185                 190         


Pro Leu Gly Tyr Pro Ile Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly 
        195                 200                 205             


Leu Pro Tyr Thr Thr Gly Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly 
    210                 215                 220                 


Val Ala Gly Ala Ala Gly Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val 
225                 230                 235                 240 


Gly Pro Gln Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe 
                245                 250                 255     


Gly Ala Gly Ala Ala Gly Val Leu Pro Gly Val Gly Gly Ala Gly Val 
            260                 265                 270         


Pro Gly Val Pro Gly Ala Ile Pro Gly Ile Gly Gly Ile Ala Gly Val 
        275                 280                 285             


Gly Thr Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala 
    290                 295                 300                 


Lys Tyr Gly Ala Ala Ala Gly Leu Val Pro Gly Gly Pro Gly Phe Gly 
305                 310                 315                 320 


Pro Gly Val Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
                325                 330                 335     


Pro Gly Ala Gly Ile Pro Val Val Pro Gly Ala Gly Ile Pro Gly Ala 
            340                 345                 350         


Ala Val Pro Gly Val Val Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala 
        355                 360                 365             


Lys Ala Ala Lys Tyr Gly Ala Arg Pro Gly Val Gly Val Gly Gly Ile 
    370                 375                 380                 


Pro Thr Tyr Gly Val Gly Ala Gly Gly Phe Pro Gly Phe Gly Val Gly 
385                 390                 395                 400 


Val Gly Gly Ile Pro Gly Val Ala Gly Val Pro Gly Val Gly Gly Val 
                405                 410                 415     


Pro Gly Val Gly Gly Val Pro Gly Val Gly Ile Ser Pro Glu Ala Gln 
            420                 425                 430         


Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Leu Val Pro Gly Val 
        435                 440                 445             


Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro 
    450                 455                 460                 


Gly Val Gly Leu Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val 
465                 470                 475                 480 


Ala Pro Gly Val Gly Val Ala Pro Gly Ile Gly Pro Gly Gly Val Ala 
                485                 490                 495     


Ala Ala Ala Lys Ser Ala Ala Lys Val Ala Ala Lys Ala Gln Leu Arg 
            500                 505                 510         


Ala Ala Ala Gly Leu Gly Ala Gly Ile Pro Gly Leu Gly Val Gly Val 
        515                 520                 525             


Gly Val Pro Gly Leu Gly Val Gly Ala Gly Val Pro Gly Leu Gly Val 
    530                 535                 540                 


Gly Ala Gly Val Pro Gly Phe Gly Ala Val Pro Gly Ala Leu Ala Ala 
545                 550                 555                 560 


Ala Lys Ala Ala Lys Tyr Gly Ala Ala Val Pro Gly Val Leu Gly Gly 
                565                 570                 575     


Leu Gly Ala Leu Gly Gly Val Gly Ile Pro Gly Gly Val Val Gly Ala 
            580                 585                 590         


Gly Pro Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala 
        595                 600                 605             


Gln Phe Gly Leu Val Gly Ala Ala Gly Leu Gly Gly Leu Gly Val Gly 
    610                 615                 620                 


Gly Leu Gly Val Pro Gly Val Gly Gly Leu Gly Gly Ile Pro Pro Ala 
625                 630                 635                 640 


Ala Ala Ala Lys Ala Ala Lys Tyr Gly Val Ala Ala Arg Pro Gly Phe 
                645                 650                 655     


Gly Leu Ser Pro Ile Phe Pro Gly Gly Ala Cys Leu Gly Lys Ala Cys 
            660                 665                 670         


Gly Arg Lys Arg Lys 
        675         


<210>  1057
<211>  692
<212>  PRT
<213>  Homo sapiens

<400>  1057

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30          


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45              


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60                  


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80  


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95      


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 
            100                 105                 110         


Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Ala Pro Ser 
        115                 120                 125             


Val Pro Gly Ala Val Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly 
    130                 135                 140                 


Lys Val Pro Gly Val Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu 
145                 150                 155                 160 


Pro Gly Ala Arg Phe Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr 
                165                 170                 175     


Gly Ala Gly Val Lys Pro Lys Ala Pro Gly Val Gly Gly Ala Phe Ala 
            180                 185                 190         


Gly Ile Pro Gly Val Gly Pro Phe Gly Gly Pro Gln Pro Gly Val Pro 
        195                 200                 205             


Leu Gly Tyr Pro Ile Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly Leu 
    210                 215                 220                 


Pro Tyr Thr Thr Gly Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly Val 
225                 230                 235                 240 


Ala Gly Ala Ala Gly Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val Gly 
                245                 250                 255     


Pro Gln Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe Gly 
            260                 265                 270         


Ala Gly Ala Ala Gly Val Leu Pro Gly Val Gly Gly Ala Gly Val Pro 
        275                 280                 285             


Gly Val Pro Gly Ala Ile Pro Gly Ile Gly Gly Ile Ala Gly Val Gly 
    290                 295                 300                 


Thr Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys 
305                 310                 315                 320 


Tyr Gly Ala Ala Ala Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro 
                325                 330                 335     


Gly Val Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
            340                 345                 350         


Gly Ala Gly Ile Pro Val Val Pro Gly Ala Gly Ile Pro Gly Ala Ala 
        355                 360                 365             


Val Pro Gly Val Val Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala Lys 
    370                 375                 380                 


Ala Ala Lys Tyr Gly Ala Arg Pro Gly Val Gly Val Gly Gly Ile Pro 
385                 390                 395                 400 


Thr Tyr Gly Val Gly Ala Gly Gly Phe Pro Gly Phe Gly Val Gly Val 
                405                 410                 415     


Gly Gly Ile Pro Gly Val Ala Gly Val Pro Gly Val Gly Gly Val Pro 
            420                 425                 430         


Gly Val Gly Gly Val Pro Gly Val Gly Ile Ser Pro Glu Ala Gln Ala 
        435                 440                 445             


Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Leu Val Pro Gly Val Gly 
    450                 455                 460                 


Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly 
465                 470                 475                 480 


Val Gly Leu Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala 
                485                 490                 495     


Pro Gly Val Gly Val Ala Pro Gly Ile Gly Pro Gly Gly Val Ala Ala 
            500                 505                 510         


Ala Ala Lys Ser Ala Ala Lys Val Ala Ala Lys Ala Gln Leu Arg Ala 
        515                 520                 525             


Ala Ala Gly Leu Gly Ala Gly Ile Pro Gly Leu Gly Val Gly Val Gly 
    530                 535                 540                 


Val Pro Gly Leu Gly Val Gly Ala Gly Val Pro Gly Leu Gly Val Gly 
545                 550                 555                 560 


Ala Gly Val Pro Gly Phe Gly Ala Val Pro Gly Ala Leu Ala Ala Ala 
                565                 570                 575     


Lys Ala Ala Lys Tyr Gly Ala Ala Val Pro Gly Val Leu Gly Gly Leu 
            580                 585                 590         


Gly Ala Leu Gly Gly Val Gly Ile Pro Gly Gly Val Val Gly Ala Gly 
        595                 600                 605             


Pro Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln 
    610                 615                 620                 


Phe Gly Leu Val Gly Ala Ala Gly Leu Gly Gly Leu Gly Val Gly Gly 
625                 630                 635                 640 


Leu Gly Val Pro Gly Val Gly Gly Leu Gly Gly Ile Pro Pro Ala Ala 
                645                 650                 655     


Ala Ala Lys Ala Ala Lys Tyr Gly Val Ala Ala Arg Pro Gly Phe Gly 
            660                 665                 670         


Leu Ser Pro Ile Phe Pro Gly Gly Ala Cys Leu Gly Lys Ala Cys Gly 
        675                 680                 685             


Arg Lys Arg Lys 
    690         


<210>  1058
<211>  711
<212>  PRT
<213>  Homo sapiens

<400>  1058

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30          


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45              


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60                  


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80  


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95      


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 
            100                 105                 110         


Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Ala Pro Ser 
        115                 120                 125             


Val Pro Gly Ala Val Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly 
    130                 135                 140                 


Lys Val Pro Gly Val Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu 
145                 150                 155                 160 


Pro Gly Ala Arg Phe Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr 
                165                 170                 175     


Gly Ala Gly Val Lys Pro Lys Ala Pro Gly Val Gly Gly Ala Phe Ala 
            180                 185                 190         


Gly Ile Pro Gly Val Gly Pro Phe Gly Gly Pro Gln Pro Gly Val Pro 
        195                 200                 205             


Leu Gly Tyr Pro Ile Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly Leu 
    210                 215                 220                 


Pro Tyr Thr Thr Gly Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly Val 
225                 230                 235                 240 


Ala Gly Ala Ala Gly Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val Gly 
                245                 250                 255     


Pro Gln Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe Gly 
            260                 265                 270         


Ala Gly Ala Ala Gly Val Leu Pro Gly Val Gly Gly Ala Gly Val Pro 
        275                 280                 285             


Gly Val Pro Gly Ala Ile Pro Gly Ile Gly Gly Ile Ala Gly Val Gly 
    290                 295                 300                 


Thr Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys 
305                 310                 315                 320 


Tyr Gly Ala Ala Ala Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro 
                325                 330                 335     


Gly Val Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
            340                 345                 350         


Gly Ala Gly Ile Pro Val Val Pro Gly Ala Gly Ile Pro Gly Ala Ala 
        355                 360                 365             


Val Pro Gly Val Val Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala Lys 
    370                 375                 380                 


Ala Ala Lys Tyr Gly Ala Arg Pro Gly Val Gly Val Gly Gly Ile Pro 
385                 390                 395                 400 


Thr Tyr Gly Val Gly Ala Gly Gly Phe Pro Gly Phe Gly Val Gly Val 
                405                 410                 415     


Gly Gly Ile Pro Gly Val Ala Gly Val Pro Gly Val Gly Gly Val Pro 
            420                 425                 430         


Gly Val Gly Gly Val Pro Gly Val Gly Ile Ser Pro Glu Ala Gln Ala 
        435                 440                 445             


Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Val Gly Thr Pro Ala Ala 
    450                 455                 460                 


Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln Phe Gly Leu Val Pro 
465                 470                 475                 480 


Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val 
                485                 490                 495     


Ala Pro Gly Val Gly Leu Ala Pro Gly Val Gly Val Ala Pro Gly Val 
            500                 505                 510         


Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Ile Gly Pro Gly Gly 
        515                 520                 525             


Val Ala Ala Ala Ala Lys Ser Ala Ala Lys Val Ala Ala Lys Ala Gln 
    530                 535                 540                 


Leu Arg Ala Ala Ala Gly Leu Gly Ala Gly Ile Pro Gly Leu Gly Val 
545                 550                 555                 560 


Gly Val Gly Val Pro Gly Leu Gly Val Gly Ala Gly Val Pro Gly Leu 
                565                 570                 575     


Gly Val Gly Ala Gly Val Pro Gly Phe Gly Ala Val Pro Gly Ala Leu 
            580                 585                 590         


Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Val Pro Gly Val Leu 
        595                 600                 605             


Gly Gly Leu Gly Ala Leu Gly Gly Val Gly Ile Pro Gly Gly Val Val 
    610                 615                 620                 


Gly Ala Gly Pro Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys 
625                 630                 635                 640 


Ala Ala Gln Phe Gly Leu Val Gly Ala Ala Gly Leu Gly Gly Leu Gly 
                645                 650                 655     


Val Gly Gly Leu Gly Val Pro Gly Val Gly Gly Leu Gly Gly Ile Pro 
            660                 665                 670         


Pro Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Val Ala Ala Arg Pro 
        675                 680                 685             


Gly Phe Gly Leu Ser Pro Ile Phe Pro Gly Gly Ala Cys Leu Gly Lys 
    690                 695                 700                 


Ala Cys Gly Arg Lys Arg Lys 
705                 710     


<210>  1059
<211>  705
<212>  PRT
<213>  Homo sapiens

<400>  1059

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30          


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45              


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60                  


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80  


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95      


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 
            100                 105                 110         


Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Gly Ala Val 
        115                 120                 125             


Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys Val Pro Gly Val 
    130                 135                 140                 


Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu Pro Gly Ala Arg Phe 
145                 150                 155                 160 


Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr Gly Ala Gly Val Lys 
                165                 170                 175     


Pro Lys Ala Pro Gly Val Gly Gly Ala Phe Ala Gly Ile Pro Gly Val 
            180                 185                 190         


Gly Pro Phe Gly Gly Pro Gln Pro Gly Val Pro Leu Gly Tyr Pro Ile 
        195                 200                 205             


Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly Leu Pro Tyr Thr Thr Gly 
    210                 215                 220                 


Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly Val Ala Gly Ala Ala Gly 
225                 230                 235                 240 


Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val Gly Pro Gln Ala Ala Ala 
                245                 250                 255     


Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe Gly Ala Gly Ala Ala Gly 
            260                 265                 270         


Val Leu Pro Gly Val Gly Gly Ala Gly Val Pro Gly Val Pro Gly Ala 
        275                 280                 285             


Ile Pro Gly Ile Gly Gly Ile Ala Gly Val Gly Thr Pro Ala Ala Ala 
    290                 295                 300                 


Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Ala 
305                 310                 315                 320 


Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro Gly Val Val Gly Val 
                325                 330                 335     


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Ile Pro 
            340                 345                 350         


Val Val Pro Gly Ala Gly Ile Pro Gly Ala Ala Val Pro Gly Val Val 
        355                 360                 365             


Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Lys Tyr Gly 
    370                 375                 380                 


Ala Arg Pro Gly Val Gly Val Gly Gly Ile Pro Thr Tyr Gly Val Gly 
385                 390                 395                 400 


Ala Gly Gly Phe Pro Gly Phe Gly Val Gly Val Gly Gly Ile Pro Gly 
                405                 410                 415     


Val Ala Gly Val Pro Gly Val Gly Gly Val Pro Gly Val Gly Gly Val 
            420                 425                 430         


Pro Gly Val Gly Ile Ser Pro Glu Ala Gln Ala Ala Ala Ala Ala Lys 
        435                 440                 445             


Ala Ala Lys Tyr Gly Leu Val Pro Gly Val Gly Val Ala Pro Gly Val 
    450                 455                 460                 


Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Leu Ala Pro 
465                 470                 475                 480 


Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val 
                485                 490                 495     


Ala Pro Gly Ile Gly Pro Gly Gly Val Ala Ala Ala Ala Lys Ser Ala 
            500                 505                 510         


Ala Lys Val Ala Ala Lys Ala Gln Leu Arg Ala Ala Ala Gly Leu Gly 
        515                 520                 525             


Ala Gly Ile Pro Gly Leu Gly Val Gly Val Gly Val Pro Gly Leu Gly 
    530                 535                 540                 


Val Gly Ala Gly Val Pro Gly Leu Gly Val Gly Ala Gly Val Pro Gly 
545                 550                 555                 560 


Phe Gly Ala Val Pro Gly Ala Leu Ala Ala Ala Lys Ala Ala Lys Tyr 
                565                 570                 575     


Gly Ala Ala Val Pro Gly Val Leu Gly Gly Leu Gly Ala Leu Gly Gly 
            580                 585                 590         


Val Gly Ile Pro Gly Gly Val Val Gly Ala Gly Pro Ala Ala Ala Ala 
        595                 600                 605             


Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln Phe Gly Leu Val Gly 
    610                 615                 620                 


Ala Ala Gly Leu Gly Gly Leu Gly Val Gly Gly Leu Gly Val Pro Gly 
625                 630                 635                 640 


Val Gly Gly Leu Gly Gly Ile Pro Pro Ala Ala Ala Ala Lys Ala Ala 
                645                 650                 655     


Lys Tyr Gly Ala Ala Gly Leu Gly Gly Val Leu Gly Gly Ala Gly Gln 
            660                 665                 670         


Phe Pro Leu Gly Gly Val Ala Ala Arg Pro Gly Phe Gly Leu Ser Pro 
        675                 680                 685             


Ile Phe Pro Gly Gly Ala Cys Leu Gly Lys Ala Cys Gly Arg Lys Arg 
    690                 695                 700                 


Lys 
705 


<210>  1060
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  1060

Met Glu Gly Ser Pro Ala Gly Pro Ile Glu Gln Lys Glu Ala Arg Trp 
1               5                   10                  15      


Glu Ser Ser Trp Glu Glu Gln Pro Asp Trp Thr Leu Gly Cys Leu Ser 
            20                  25                  30          


Pro Glu Ser Gln Phe Arg Ile Pro Gly Leu Pro Gly Cys Ile Leu Ser 
        35                  40                  45              


Phe Gln Leu Lys Val Cys Phe Leu Pro Val Met Trp Leu Phe Ile Leu 
    50                  55                  60                  


Leu Ser Leu Ala Leu Ile Ser Asp Ala Met Val Met Asp Glu Lys Val 
65                  70                  75                  80  


Lys Arg Ser Phe Val Leu Asp Thr Ala Ser Ala Ile Cys Asn Tyr Asn 
                85                  90                  95      


Ala His Tyr Lys Asn His Pro Lys Tyr Trp Cys Arg Gly Tyr Phe Arg 
            100                 105                 110         


Asp Tyr Cys Asn Ile Ile Ala Phe Ser Pro Asn Ser Thr Asn His Val 
        115                 120                 125             


Ala Leu Arg Asp Thr Gly Asn Gln Leu Ile Val Thr Met Ser Cys Leu 
    130                 135                 140                 


Thr Lys Glu Asp Thr Gly Trp Tyr Trp Cys Gly Ile Gln Arg Asp Phe 
145                 150                 155                 160 


Ala Arg Asp Asp Met Asp Phe Thr Glu Leu Ile Val Thr Asp Asp Lys 
                165                 170                 175     


Gly Thr Leu Ala Asn Asp Phe Trp Ser Gly Lys Asp Leu Ser Gly Asn 
            180                 185                 190         


Lys Thr Arg Ser Cys Lys Ala Pro Lys Val Val Arg Lys Ala Asp Arg 
        195                 200                 205             


Ser Arg Thr Ser Ile Leu Ile Ile Cys Ile Leu Ile Thr Gly Leu Gly 
    210                 215                 220                 


Ile Ile Ser Val Ile Ser His Leu Thr Lys Arg Arg Arg Ser Gln Arg 
225                 230                 235                 240 


Asn Arg Arg Val Gly Asn Thr Leu Lys Pro Phe Ser Arg Val Leu Thr 
                245                 250                 255     


Pro Lys Glu Met Ala Pro Thr Glu Gln Met 
            260                 265     


<210>  1061
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  1061

Met Ala Gln Pro Tyr Pro Pro Ala Gln Tyr Pro Pro Pro Pro Gln Asn 
1               5                   10                  15      


Gly Ile Pro Ala Glu Tyr Ala Pro Pro Pro Pro His Pro Thr Gln Asp 
            20                  25                  30          


Tyr Ser Gly Gln Thr Pro Val Pro Thr Glu His Gly Met Thr Leu Tyr 
        35                  40                  45              


Thr Pro Ala Gln Thr His Pro Glu Gln Pro Gly Ser Glu Ala Ser Thr 
    50                  55                  60                  


Gln Pro Ile Ala Gly Thr Gln Thr Val Pro Gln Thr Asp Glu Ala Ala 
65                  70                  75                  80  


Gln Thr Asp Ser Gln Pro Leu His Pro Ser Asp Pro Thr Glu Lys Gln 
                85                  90                  95      


Gln Pro Lys Arg Leu His Val Ser Asn Ile Pro Phe Arg Phe Arg Asp 
            100                 105                 110         


Pro Asp Leu Arg Gln Met Phe Gly Gln Phe Gly Lys Ile Leu Asp Val 
        115                 120                 125             


Glu Ile Ile Phe Asn Glu Arg Gly Ser Lys Gly Phe Gly Phe Val Thr 
    130                 135                 140                 


Phe Glu Thr Ser Ser Asp Ala Asp Arg Ala Arg Glu Lys Leu Asn Gly 
145                 150                 155                 160 


Thr Ile Val Glu Gly Arg Lys Ile Glu Val Asn Asn Ala Thr Ala Arg 
                165                 170                 175     


Val Met Thr Asn Lys Lys Thr Gly Asn Pro Tyr Thr Asn Gly Trp Lys 
            180                 185                 190         


Leu Asn Pro Val Val Gly Ala Val Tyr Gly Pro Glu Phe Tyr Ala Val 
        195                 200                 205             


Thr Gly Phe Pro Tyr Pro Thr Thr Gly Thr Ala Val Ala Tyr Arg Gly 
    210                 215                 220                 


Ala His Leu Arg Gly Arg Gly Arg Ala Val Tyr Asn Thr Phe Arg Ala 
225                 230                 235                 240 


Ala Pro Pro Pro Pro Pro Ile Pro Thr Tyr Gly Ala Val Val Tyr Gln 
                245                 250                 255     


Asp Gly Phe Tyr Gly Ala Glu Ile Tyr Gly Gly Tyr Ala Ala Tyr Arg 
            260                 265                 270         


Tyr Ala Gln Pro Ala Ala Ala Ala Ala Ala Tyr Ser Asp Ser Tyr Gly 
        275                 280                 285             


Arg Val Tyr Ala Ala Ala Asp Pro Tyr His His Thr Ile Gly Pro Ala 
    290                 295                 300                 


Ala Thr Tyr Ser Ile Gly Thr Met 
305                 310         


<210>  1062
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  1062

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Asp Leu Thr His 
1               5                   10                  15      


Arg Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys 
            20                  25                  30          


Asn Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro 
        35                  40                  45              


Ile Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr 
    50                  55                  60                  


Thr His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly 
65                  70                  75                  80  


Thr Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr 
                85                  90                  95      


Glu Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr 
            100                 105                 110         


Thr Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala 
        115                 120                 125             


Gly Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu 
    130                 135                 140                 


Ala Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg 
145                 150                 155                 160 


Lys Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr 
                165                 170                 175     


Gly Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro 
            180                 185                 190         


Thr Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp 
        195                 200                 205             


Glu Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser 
    210                 215                 220                 


Lys Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 
225                 230                 235         


<210>  1063
<211>  506
<212>  PRT
<213>  Homo sapiens

<400>  1063

Met Gly Cys Ser Ala Lys Ala Arg Trp Ala Ala Gly Ala Leu Gly Val 
1               5                   10                  15      


Ala Gly Leu Leu Cys Ala Val Leu Gly Ala Val Met Ile Val Met Val 
            20                  25                  30          


Pro Ser Leu Ile Lys Gln Gln Val Leu Lys Asn Val Arg Ile Asp Pro 
        35                  40                  45              


Ser Ser Leu Ser Phe Asn Met Trp Lys Glu Ile Pro Ile Pro Phe Tyr 
    50                  55                  60                  


Leu Ser Val Tyr Phe Phe Asp Val Met Asn Pro Ser Glu Ile Leu Lys 
65                  70                  75                  80  


Gly Glu Lys Pro Gln Val Arg Glu Arg Gly Pro Tyr Val Tyr Arg Glu 
                85                  90                  95      


Phe Arg His Lys Ser Asn Ile Thr Phe Asn Asn Asn Asp Thr Val Ser 
            100                 105                 110         


Phe Leu Glu Tyr Arg Thr Phe Gln Phe Gln Pro Ser Lys Ser His Gly 
        115                 120                 125             


Ser Glu Ser Asp Tyr Ile Val Met Pro Asn Ile Leu Val Leu Gly Ala 
    130                 135                 140                 


Ala Val Met Met Glu Asn Lys Pro Met Thr Leu Lys Leu Ile Met Thr 
145                 150                 155                 160 


Leu Ala Phe Thr Thr Leu Gly Glu Arg Ala Phe Met Asn Arg Thr Val 
                165                 170                 175     


Gly Glu Ile Met Trp Gly Tyr Lys Asp Pro Leu Val Asn Leu Ile Asn 
            180                 185                 190         


Lys Tyr Phe Pro Gly Met Phe Pro Phe Lys Asp Lys Phe Gly Leu Phe 
        195                 200                 205             


Ala Glu Leu Asn Asn Ser Asp Ser Gly Leu Phe Thr Val Phe Thr Gly 
    210                 215                 220                 


Val Gln Asn Ile Ser Arg Ile His Leu Val Asp Lys Trp Asn Gly Leu 
225                 230                 235                 240 


Ser Lys Val Asp Phe Trp His Ser Asp Gln Cys Asn Met Ile Asn Gly 
                245                 250                 255     


Thr Ser Gly Gln Met Trp Pro Pro Phe Met Thr Pro Glu Ser Ser Leu 
            260                 265                 270         


Glu Phe Tyr Ser Pro Glu Ala Cys Arg Ser Met Lys Leu Met Tyr Lys 
        275                 280                 285             


Glu Ser Gly Val Phe Glu Gly Ile Pro Thr Tyr Arg Phe Val Ala Pro 
    290                 295                 300                 


Lys Thr Leu Phe Ala Asn Gly Ser Ile Tyr Pro Pro Asn Glu Gly Phe 
305                 310                 315                 320 


Cys Pro Cys Leu Glu Ser Gly Ile Gln Asn Val Ser Thr Cys Arg Phe 
                325                 330                 335     


Ser Ala Pro Leu Phe Leu Ser His Pro His Phe Leu Asn Ala Asp Pro 
            340                 345                 350         


Val Leu Ala Glu Ala Val Thr Gly Leu His Pro Asn Gln Glu Ala His 
        355                 360                 365             


Ser Leu Phe Leu Asp Ile His Pro Val Thr Gly Ile Pro Met Asn Cys 
    370                 375                 380                 


Ser Val Lys Leu Gln Leu Ser Leu Tyr Met Lys Ser Val Ala Gly Ile 
385                 390                 395                 400 


Gly Gln Thr Gly Lys Ile Glu Pro Val Val Leu Pro Leu Leu Trp Phe 
                405                 410                 415     


Ala Glu Ser Gly Ala Met Glu Gly Glu Thr Leu His Thr Phe Tyr Thr 
            420                 425                 430         


Gln Leu Val Leu Met Pro Lys Val Met His Tyr Ala Gln Tyr Val Leu 
        435                 440                 445             


Leu Ala Leu Gly Cys Val Leu Leu Leu Val Pro Val Ile Cys Gln Ile 
    450                 455                 460                 


Arg Ser Gln Gly Pro Glu Asp Thr Val Ser Gln Pro Gly Leu Ala Ala 
465                 470                 475                 480 


Gly Pro Asp Arg Pro Pro Ser Pro Tyr Thr Pro Leu Leu Pro Asp Ser 
                485                 490                 495     


Pro Ser Gly Gln Pro Pro Ser Pro Thr Ala 
            500                 505     


<210>  1064
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  1064

Met Ala Pro Ser Pro Arg Thr Gly Ser Arg Gln Asp Ala Thr Ala Leu 
1               5                   10                  15      


Pro Ser Met Ser Ser Thr Phe Trp Ala Phe Met Ile Leu Ala Ser Leu 
            20                  25                  30          


Leu Ile Ala Tyr Cys Ser Gln Leu Ala Ala Gly Thr Cys Glu Ile Val 
        35                  40                  45              


Thr Leu Asp Arg Asp Ser Ser Gln Pro Arg Arg Thr Ile Ala Arg Gln 
    50                  55                  60                  


Thr Ala Arg Cys Ala Cys Arg Lys Gly Gln Ile Ala Gly Thr Thr Arg 
65                  70                  75                  80  


Ala Arg Pro Ala Cys Val Asp Ala Arg Ile Ile Lys Thr Lys Gln Trp 
                85                  90                  95      


Cys Asp Met Leu Pro Cys Leu Glu Gly Glu Gly Cys Asp Leu Leu Ile 
            100                 105                 110         


Asn Arg Ser Gly Trp Thr Cys Thr Gln Pro Gly Gly Arg Ile Lys Thr 
        115                 120                 125             


Thr Thr Val Ser 
    130         


<210>  1065
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  1065

Met Asn Ala Ser Glu Phe Arg Arg Arg Gly Lys Glu Met Val Asp Tyr 
1               5                   10                  15      


Val Ala Asn Tyr Met Glu Gly Ile Glu Gly Arg Gln Val Tyr Pro Asp 
            20                  25                  30          


Val Glu Pro Gly Tyr Leu Arg Pro Leu Ile Pro Ala Ala Ala Pro Gln 
        35                  40                  45              


Glu Pro Asp Thr Phe Glu Asp Ile Ile Asn Asp Val Glu Lys Ile Ile 
    50                  55                  60                  


Met Pro Gly Val Thr His Trp His Ser Pro Tyr Phe Phe Ala Tyr Phe 
65                  70                  75                  80  


Pro Thr Ala Ser Ser Tyr Pro Ala Met Leu Ala Asp Met Leu Cys Gly 
                85                  90                  95      


Ala Ile Gly Cys Ile Gly Phe Ser Trp Ala Ala Ser Pro Ala Cys Thr 
            100                 105                 110         


Glu Leu Glu Thr Val Met Met Asp Trp Leu Gly Lys Met Leu Glu Leu 
        115                 120                 125             


Pro Lys Ala Phe Leu Asn Glu Lys Ala Gly Glu Gly Gly Gly Val Ile 
    130                 135                 140                 


Gln Gly Ser Ala Ser Glu Ala Thr Leu Val Ala Leu Leu Ala Ala Arg 
145                 150                 155                 160 


Thr Lys Val Ile His Arg Leu Gln Ala Ala Ser Pro Glu Leu Thr Gln 
                165                 170                 175     


Ala Ala Ile Met Glu Lys Leu Val Ala Tyr Ser Ser Asp Gln Ala His 
            180                 185                 190         


Ser Ser Val Glu Arg Ala Gly Leu Ile Gly Gly Val Lys Leu Lys Ala 
        195                 200                 205             


Ile Pro Ser Asp Gly Asn Phe Ala Met Arg Ala Ser Ala Leu Gln Glu 
    210                 215                 220                 


Ala Leu Glu Arg Asp Lys Ala Ala Gly Leu Ile Pro Phe Phe Met Val 
225                 230                 235                 240 


Ala Thr Leu Gly Thr Thr Thr Cys Cys Ser Phe Asp Asn Leu Leu Glu 
                245                 250                 255     


Val Gly Pro Ile Cys Asn Lys Glu Asp Ile Trp Leu His Val Asp Ala 
            260                 265                 270         


Ala Tyr Ala Gly Ser Ala Phe Ile Cys Pro Glu Phe Arg His Leu Leu 
        275                 280                 285             


Asn Gly Val Glu Phe Ala Asp Ser Phe Asn Phe Asn Pro His Lys Trp 
    290                 295                 300                 


Leu Leu Val Asn Phe Asp Cys Ser Ala Met Trp Val Lys Lys Arg Thr 
305                 310                 315                 320 


Asp Leu Thr Gly Ala Phe Arg Leu Asp Pro Thr Tyr Leu Lys His Ser 
                325                 330                 335     


His Gln Asp Ser Gly Leu Ile Thr Asp Tyr Arg His Trp Gln Ile Pro 
            340                 345                 350         


Leu Gly Arg Arg Phe Arg Ser Leu Lys Met Trp Phe Val Phe Arg Met 
        355                 360                 365             


Tyr Gly Val Lys Gly Leu Gln Ala Tyr Ile Arg Lys His Val Gln Leu 
    370                 375                 380                 


Ser His Glu Phe Glu Ser Leu Val Arg Gln Asp Pro Arg Phe Glu Ile 
385                 390                 395                 400 


Cys Val Glu Val Ile Leu Gly Leu Val Cys Phe Arg Leu Lys Gly Ser 
                405                 410                 415     


Asn Lys Val Asn Glu Ala Leu Leu Gln Arg Ile Asn Ser Ala Lys Lys 
            420                 425                 430         


Ile His Leu Val Pro Cys His Leu Arg Asp Lys Phe Val Leu Arg Phe 
        435                 440                 445             


Ala Ile Cys Ser Arg Thr Val Glu Ser Ala His Val Gln Arg Ala Trp 
    450                 455                 460                 


Glu His Ile Lys Glu Leu Ala Ala Asp Val Leu Arg Ala Glu Arg Glu 
465                 470                 475                 480 


<210>  1066
<211>  727
<212>  PRT
<213>  Homo sapiens

<400>  1066

Met Ala Phe Gln Lys Ala Val Lys Gly Thr Ile Leu Val Gly Gly Gly 
1               5                   10                  15      


Ala Leu Ala Thr Val Leu Gly Leu Ser Gln Phe Ala His Tyr Arg Arg 
            20                  25                  30          


Lys Gln Met Asn Leu Ala Tyr Val Lys Ala Ala Asp Cys Ile Ser Glu 
        35                  40                  45              


Pro Val Asn Arg Glu Pro Pro Ser Arg Glu Ala Gln Leu Leu Thr Leu 
    50                  55                  60                  


Gln Asn Thr Ser Glu Phe Asp Ile Leu Val Ile Gly Gly Gly Ala Thr 
65                  70                  75                  80  


Gly Ser Gly Cys Ala Leu Asp Ala Val Thr Arg Gly Leu Lys Thr Ala 
                85                  90                  95      


Leu Val Glu Arg Asp Asp Phe Ser Ser Gly Thr Ser Ser Arg Ser Thr 
            100                 105                 110         


Lys Leu Ile His Gly Gly Val Arg Tyr Leu Gln Lys Ala Ile Met Lys 
        115                 120                 125             


Leu Asp Ile Glu Gln Tyr Arg Met Val Lys Glu Ala Leu His Glu Arg 
    130                 135                 140                 


Ala Asn Leu Leu Glu Ile Ala Pro His Leu Ser Ala Pro Leu Pro Ile 
145                 150                 155                 160 


Met Leu Pro Val Tyr Lys Trp Trp Gln Leu Pro Tyr Tyr Trp Val Gly 
                165                 170                 175     


Ile Lys Leu Tyr Asp Leu Val Ala Gly Ser Asn Cys Leu Lys Ser Ser 
            180                 185                 190         


Tyr Val Leu Ser Lys Ser Arg Ala Leu Glu His Phe Pro Met Leu Gln 
        195                 200                 205             


Lys Asp Lys Leu Val Gly Ala Ile Val Tyr Tyr Asp Gly Gln His Asn 
    210                 215                 220                 


Asp Ala Arg Met Asn Leu Ala Ile Ala Leu Thr Ala Ala Arg Tyr Gly 
225                 230                 235                 240 


Ala Ala Thr Ala Asn Tyr Met Glu Val Val Ser Leu Leu Lys Lys Thr 
                245                 250                 255     


Asp Pro Gln Thr Gly Lys Val Arg Val Ser Gly Ala Arg Cys Lys Asp 
            260                 265                 270         


Val Leu Thr Gly Gln Glu Phe Asp Val Arg Ala Lys Cys Val Ile Asn 
        275                 280                 285             


Ala Thr Gly Pro Phe Thr Asp Ser Val Arg Lys Met Asp Asp Lys Asp 
    290                 295                 300                 


Ala Ala Ala Ile Cys Gln Pro Ser Ala Gly Val His Ile Val Met Pro 
305                 310                 315                 320 


Gly Tyr Tyr Ser Pro Glu Ser Met Gly Leu Leu Asp Pro Ala Thr Ser 
                325                 330                 335     


Asp Gly Arg Val Ile Phe Phe Leu Pro Trp Gln Lys Met Thr Ile Ala 
            340                 345                 350         


Gly Thr Thr Asp Thr Pro Thr Asp Val Thr His His Pro Ile Pro Ser 
        355                 360                 365             


Glu Glu Asp Ile Asn Phe Ile Leu Asn Glu Val Arg Asn Tyr Leu Ser 
    370                 375                 380                 


Cys Asp Val Glu Val Arg Arg Gly Asp Val Leu Ala Ala Trp Ser Gly 
385                 390                 395                 400 


Ile Arg Pro Leu Val Thr Asp Pro Lys Ser Ala Asp Thr Gln Ser Ile 
                405                 410                 415     


Ser Arg Asn His Val Val Asp Ile Ser Glu Ser Gly Leu Ile Thr Ile 
            420                 425                 430         


Ala Gly Gly Lys Trp Thr Thr Tyr Arg Ser Met Ala Glu Asp Thr Ile 
        435                 440                 445             


Asn Ala Ala Val Lys Thr His Asn Leu Lys Ala Gly Pro Ser Arg Thr 
    450                 455                 460                 


Val Gly Leu Phe Leu Gln Gly Gly Lys Asp Trp Ser Pro Thr Leu Tyr 
465                 470                 475                 480 


Ile Arg Leu Val Gln Asp Tyr Gly Leu Glu Ser Glu Val Ala Gln His 
                485                 490                 495     


Leu Ala Ala Thr Tyr Gly Asp Lys Ala Phe Glu Val Ala Lys Met Ala 
            500                 505                 510         


Ser Val Thr Gly Lys Arg Trp Pro Ile Val Gly Val Arg Leu Val Ser 
        515                 520                 525             


Glu Phe Pro Tyr Ile Glu Ala Glu Val Lys Tyr Gly Ile Lys Glu Tyr 
    530                 535                 540                 


Ala Cys Thr Ala Val Asp Met Ile Ser Arg Arg Thr Arg Leu Ala Phe 
545                 550                 555                 560 


Leu Asn Val Gln Ala Ala Glu Glu Ala Leu Pro Arg Ile Val Glu Leu 
                565                 570                 575     


Met Gly Arg Glu Leu Asn Trp Asp Asp Tyr Lys Lys Gln Glu Gln Leu 
            580                 585                 590         


Glu Thr Ala Arg Lys Phe Leu Tyr Tyr Glu Met Gly Tyr Lys Ser Arg 
        595                 600                 605             


Ser Glu Gln Leu Thr Asp Arg Ser Glu Ile Ser Leu Leu Pro Ser Asp 
    610                 615                 620                 


Ile Asp Arg Tyr Lys Lys Arg Phe His Lys Phe Asp Ala Asp Gln Lys 
625                 630                 635                 640 


Gly Phe Ile Thr Ile Val Asp Val Gln Arg Val Leu Glu Ser Ile Asn 
                645                 650                 655     


Val Gln Met Asp Glu Asn Thr Leu His Glu Ile Leu Asn Glu Val Asp 
            660                 665                 670         


Leu Asn Lys Asn Gly Gln Val Glu Leu Asn Glu Phe Leu Gln Leu Met 
        675                 680                 685             


Ser Ala Ile Gln Lys Gly Arg Val Ser Gly Ser Arg Leu Ala Ile Leu 
    690                 695                 700                 


Met Lys Thr Ala Glu Glu Asn Leu Asp Arg Arg Val Pro Ile Pro Val 
705                 710                 715                 720 


Asp Arg Ser Cys Gly Gly Leu 
                725         


<210>  1067
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  1067

Met Gly Arg Lys Ser Leu Tyr Leu Leu Ile Val Gly Ile Leu Ile Ala 
1               5                   10                  15      


Tyr Tyr Ile Tyr Thr Pro Leu Pro Asp Asn Val Glu Glu Pro Trp Arg 
            20                  25                  30          


Met Met Trp Ile Asn Ala His Leu Lys Thr Ile Gln Asn Leu Ala Thr 
        35                  40                  45              


Phe Val Glu Leu Leu Gly Leu His His Phe Met Asp Ser Phe Lys Val 
    50                  55                  60                  


Val Gly Ser Phe Asp Glu Val Pro Pro Thr Ser Asp Glu Asn Val Thr 
65                  70                  75                  80  


Val Thr Glu Thr Lys Phe Asn Asn Ile Leu Val Arg Val Tyr Val Pro 
                85                  90                  95      


Lys Arg Lys Ser Glu Ala Leu Arg Arg Gly Leu Phe Tyr Ile His Gly 
            100                 105                 110         


Gly Gly Trp Cys Val Gly Ser Ala Ala Leu Ser Gly Tyr Asp Leu Leu 
        115                 120                 125             


Ser Arg Trp Thr Ala Asp Arg Leu Asp Ala Val Val Val Ser Thr Asn 
    130                 135                 140                 


Tyr Arg Leu Ala Pro Lys Tyr His Phe Pro Ile Gln Phe Glu Asp Val 
145                 150                 155                 160 


Tyr Asn Ala Leu Arg Trp Phe Leu Arg Lys Lys Val Leu Ala Lys Tyr 
                165                 170                 175     


Gly Val Asn Pro Glu Arg Ile Gly Ile Ser Gly Asp Ser Ala Gly Gly 
            180                 185                 190         


Asn Leu Ala Ala Ala Val Thr Gln Gln Leu Leu Asp Asp Pro Asp Val 
        195                 200                 205             


Lys Ile Lys Leu Lys Ile Gln Ser Leu Ile Tyr Pro Ala Leu Gln Pro 
    210                 215                 220                 


Leu Asp Val Asp Leu Pro Ser Tyr Gln Glu Asn Ser Asn Phe Leu Phe 
225                 230                 235                 240 


Leu Ser Lys Ser Leu Met Val Arg Phe Trp Ser Glu Tyr Phe Thr Thr 
                245                 250                 255     


Asp Arg Ser Leu Glu Lys Ala Met Leu Ser Arg Gln His Val Pro Val 
            260                 265                 270         


Glu Ser Ser His Leu Phe Lys Phe Val Asn Trp Ser Ser Leu Leu Pro 
        275                 280                 285             


Glu Arg Phe Ile Lys Gly His Val Tyr Asn Asn Pro Asn Tyr Gly Ser 
    290                 295                 300                 


Ser Glu Leu Ala Lys Lys Tyr Pro Gly Phe Leu Asp Val Arg Ala Ala 
305                 310                 315                 320 


Pro Leu Leu Ala Asp Asp Asn Lys Leu Arg Gly Leu Pro Leu Thr Tyr 
                325                 330                 335     


Val Ile Thr Cys Gln Tyr Asp Leu Leu Arg Asp Asp Gly Leu Met Tyr 
            340                 345                 350         


Val Thr Arg Leu Arg Asn Thr Gly Val Gln Val Thr His Asn His Val 
        355                 360                 365             


Glu Asp Gly Phe His Gly Ala Phe Ser Phe Leu Gly Leu Lys Ile Ser 
    370                 375                 380                 


His Arg Leu Ile Asn Gln Tyr Ile Glu Trp Leu Lys Glu Asn Leu 
385                 390                 395                 


<210>  1068
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  1068

Met Ala Ala Ala Glu Pro Ala Ser Ser Gly Gln Gln Ala Pro Ala Gly 
1               5                   10                  15      


Gln Gly Gln Gly Gln Arg Pro Pro Pro Gln Pro Pro Gln Ala Gln Ala 
            20                  25                  30          


Pro Gln Pro Pro Pro Pro Pro Gln Leu Gly Gly Ala Gly Gly Gly Ser 
        35                  40                  45              


Ser Arg His Glu Lys Ser Leu Gly Leu Leu Thr Thr Lys Phe Val Ser 
    50                  55                  60                  


Leu Leu Gln Glu Ala Lys Asp Gly Val Leu Asp Leu Lys Ala Ala Ala 
65                  70                  75                  80  


Asp Thr Leu Ala Val Arg Gln Lys Arg Arg Ile Tyr Asp Ile Thr Asn 
                85                  90                  95      


Val Leu Glu Gly Ile Asp Leu Ile Glu Lys Lys Ser Lys Asn Ser Ile 
            100                 105                 110         


Gln Trp Lys Gly Val Gly Ala Gly Cys Asn Thr Lys Glu Val Ile Asp 
        115                 120                 125             


Arg Leu Arg Tyr Leu Lys Ala Glu Ile Glu Asp Leu Glu Leu Lys Glu 
    130                 135                 140                 


Arg Glu Leu Asp Gln Gln Lys Leu Trp Leu Gln Gln Ser Ile Lys Asn 
145                 150                 155                 160 


Val Met Asp Asp Ser Ile Asn Asn Arg Phe Ser Tyr Val Thr His Glu 
                165                 170                 175     


Asp Ile Cys Asn Cys Phe Asn Gly Asp Thr Leu Leu Ala Ile Gln Ala 
            180                 185                 190         


Pro Ser Gly Thr Gln Leu Glu Val Pro Ile Pro Glu Met Gly Gln Asn 
        195                 200                 205             


Gly Gln Lys Lys Tyr Gln Ile Asn Leu Lys Ser His Ser Gly Pro Ile 
    210                 215                 220                 


His Val Leu Leu Ile Asn Lys Glu Ser Ser Ser Ser Lys Pro Val Val 
225                 230                 235                 240 


Phe Pro Val Pro Pro Pro Asp Asp Leu Thr Gln Pro Ser Ser Gln Ser 
                245                 250                 255     


Leu Thr Pro Val Thr Pro Gln Lys Ser Ser Met Ala Thr Gln Asn Leu 
            260                 265                 270         


Pro Glu Gln His Val Ser Glu Arg Ser Gln Ala Leu Gln Gln Thr Ser 
        275                 280                 285             


Ala Thr Asp Ile Ser Ser Gly Ser Ile Ser Gly Asp Ile Ile Asp Glu 
    290                 295                 300                 


Leu Met Ser Ser Asp Val Phe Pro Leu Leu Arg Leu Ser Pro Thr Pro 
305                 310                 315                 320 


Ala Asp Asp Tyr Asn Phe Asn Leu Asp Asp Asn Glu Gly Val Cys Asp 
                325                 330                 335     


Leu Phe Asp Val Gln Ile Leu Asn Tyr 
            340                 345 


<210>  1069
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  1069

Met Asp Asp Ser Ile Asn Asn Arg Phe Ser Tyr Val Thr His Glu Asp 
1               5                   10                  15      


Ile Cys Asn Cys Phe Asn Gly Asp Thr Leu Leu Ala Ile Gln Ala Pro 
            20                  25                  30          


Ser Gly Thr Gln Leu Glu Val Pro Ile Pro Glu Met Gly Gln Asn Gly 
        35                  40                  45              


Gln Lys Lys Tyr Gln Ile Asn Leu Lys Ser His Ser Gly Pro Ile His 
    50                  55                  60                  


Val Leu Leu Ile Asn Lys Glu Ser Ser Ser Ser Lys Pro Val Val Phe 
65                  70                  75                  80  


Pro Val Pro Pro Pro Asp Asp Leu Thr Gln Pro Ser Ser Gln Ser Leu 
                85                  90                  95      


Thr Pro Val Thr Pro Gln Lys Ser Ser Met Ala Thr Gln Asn Leu Pro 
            100                 105                 110         


Glu Gln His Val Ser Glu Arg Ser Gln Ala Leu Gln Gln Thr Ser Ala 
        115                 120                 125             


Thr Asp Ile Ser Ser Ala Gly Ser Ile Ser Gly Asp Ile Ile Asp Glu 
    130                 135                 140                 


Leu Met Ser Ser Asp Val Phe Pro Leu Leu Arg Leu Ser Pro Thr Pro 
145                 150                 155                 160 


Ala Asp Asp Tyr Asn Phe Asn Leu Asp Asp Asn Glu Gly Val Cys Asp 
                165                 170                 175     


Leu Phe Asp Val Gln Ile Leu Asn Tyr 
            180                 185 


<210>  1070
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  1070

Met His Arg Pro Arg Arg Arg Gly Thr Arg Pro Pro Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Leu Ala Ala Arg Gly Ala Ala Ala Gln Glu Thr 
            20                  25                  30          


Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser Trp Asn Ile 
        35                  40                  45              


Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp Glu Pro Met 
    50                  55                  60                  


Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu His Cys Lys 
65                  70                  75                  80  


Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys Asn Asp Ala 
                85                  90                  95      


Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser Thr Ile Tyr 
            100                 105                 110         


Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp Thr Gly Tyr 
        115                 120                 125             


Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser Ser Thr Gly 
    130                 135                 140                 


Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser Pro Gly Tyr 
145                 150                 155                 160 


Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr Arg Gly Ile 
                165                 170                 175     


Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met Glu Ser Leu 
            180                 185                 190         


His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala Phe Thr Met 
        195                 200                 205             


Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln Phe Ala Ile 
    210                 215                 220                 


Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu Thr Ser Ser 
225                 230                 235                 240 


Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu Ile Leu Glu 
                245                 250                 255     


Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser Asn Pro Met 
            260                 265                 270         


Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu Pro Gln Pro 
        275                 280                 285             


Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile Pro Met Ala 
    290                 295                 300                 


Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr Gly Val Asp 
305                 310                 315                 320 


Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln Cys Gln Pro 
                325                 330                 335     


Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala Leu Arg Phe 
            340                 345                 350         


Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro Gly Asn Gln 
        355                 360                 365             


Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp 
    370                 375                 380                 


Leu Cys Asp Ile Pro Ala Cys Gly Lys 
385                 390             


<210>  1071
<211>  1381
<212>  PRT
<213>  Homo sapiens

<400>  1071

Met Gly Lys Ala Thr Gly Arg Lys Ala Pro Leu Trp Leu Arg Ala Lys 
1               5                   10                  15      


Phe Gln Arg Leu Leu Phe Lys Leu Gly Cys Tyr Ile Gln Lys Asn Cys 
            20                  25                  30          


Gly Lys Phe Leu Val Val Gly Leu Leu Ile Phe Gly Ala Phe Ala Val 
        35                  40                  45              


Gly Leu Lys Ala Ala Asn Leu Glu Thr Asn Val Glu Glu Leu Trp Val 
    50                  55                  60                  


Glu Val Gly Gly Arg Val Ser Arg Glu Leu Asn Tyr Thr Arg Gln Lys 
65                  70                  75                  80  


Ile Gly Glu Glu Ala Met Phe Asn Pro Gln Leu Met Ile Gln Thr Pro 
                85                  90                  95      


Lys Glu Glu Gly Ala Asn Val Leu Thr Thr Glu Ala Leu Leu Gln His 
            100                 105                 110         


Leu Asp Ser Ala Leu Gln Ala Ser Arg Val His Val Tyr Met Tyr Asn 
        115                 120                 125             


Arg Gln Trp Lys Leu Glu His Leu Cys Tyr Lys Ser Gly Glu Leu Ile 
    130                 135                 140                 


Thr Glu Thr Gly Tyr Met Asp Gln Ile Ile Glu Tyr Leu Tyr Pro Cys 
145                 150                 155                 160 


Leu Ile Ile Thr Pro Leu Asp Cys Phe Trp Glu Gly Ala Lys Leu Gln 
                165                 170                 175     


Ser Gly Thr Ala Tyr Leu Leu Gly Lys Pro Pro Leu Arg Trp Thr Asn 
            180                 185                 190         


Phe Asp Pro Leu Glu Phe Leu Glu Glu Leu Lys Lys Ile Asn Tyr Gln 
        195                 200                 205             


Val Asp Ser Trp Glu Glu Met Leu Asn Lys Ala Glu Val Gly His Gly 
    210                 215                 220                 


Tyr Met Asp Arg Pro Cys Leu Asn Pro Ala Asp Pro Asp Cys Pro Ala 
225                 230                 235                 240 


Thr Ala Pro Asn Lys Asn Ser Thr Lys Pro Leu Asp Met Ala Leu Val 
                245                 250                 255     


Leu Asn Gly Gly Cys His Gly Leu Ser Arg Lys Tyr Met His Trp Gln 
            260                 265                 270         


Glu Glu Leu Ile Val Gly Gly Thr Val Lys Asn Ser Thr Gly Lys Leu 
        275                 280                 285             


Val Ser Ala His Ala Leu Gln Thr Met Phe Gln Leu Met Thr Pro Lys 
    290                 295                 300                 


Gln Met Tyr Glu His Phe Lys Gly Tyr Glu Tyr Val Ser His Ile Asn 
305                 310                 315                 320 


Trp Asn Glu Asp Lys Ala Ala Ala Ile Leu Glu Ala Trp Gln Arg Thr 
                325                 330                 335     


Tyr Val Glu Val Val His Gln Ser Val Ala Gln Asn Ser Thr Gln Lys 
            340                 345                 350         


Val Leu Ser Phe Thr Thr Thr Thr Leu Asp Asp Ile Leu Lys Ser Phe 
        355                 360                 365             


Ser Asp Val Ser Val Ile Arg Val Ala Ser Gly Tyr Leu Leu Met Leu 
    370                 375                 380                 


Ala Tyr Ala Cys Leu Thr Met Leu Arg Trp Asp Cys Ser Lys Ser Gln 
385                 390                 395                 400 


Gly Ala Val Gly Leu Ala Gly Val Leu Leu Val Ala Leu Ser Val Ala 
                405                 410                 415     


Ala Gly Leu Gly Leu Cys Ser Leu Ile Gly Ile Ser Phe Asn Ala Ala 
            420                 425                 430         


Thr Thr Gln Val Leu Pro Phe Leu Ala Leu Gly Val Gly Val Asp Asp 
        435                 440                 445             


Val Phe Leu Leu Ala His Ala Phe Ser Glu Thr Gly Gln Asn Lys Arg 
    450                 455                 460                 


Ile Pro Phe Glu Asp Arg Thr Gly Glu Cys Leu Lys Arg Thr Gly Ala 
465                 470                 475                 480 


Ser Val Ala Leu Thr Ser Ile Ser Asn Val Thr Ala Phe Phe Met Ala 
                485                 490                 495     


Ala Leu Ile Pro Ile Pro Ala Leu Arg Ala Phe Ser Leu Gln Ala Ala 
            500                 505                 510         


Val Val Val Val Phe Asn Phe Ala Met Val Leu Leu Ile Phe Pro Ala 
        515                 520                 525             


Ile Leu Ser Met Asp Leu Tyr Arg Arg Glu Asp Arg Arg Leu Asp Ile 
    530                 535                 540                 


Phe Cys Cys Phe Thr Ser Pro Cys Val Ser Arg Val Ile Gln Val Glu 
545                 550                 555                 560 


Pro Gln Ala Tyr Thr Asp Thr His Asp Asn Thr Arg Tyr Ser Pro Pro 
                565                 570                 575     


Pro Pro Tyr Ser Ser His Ser Phe Ala His Glu Thr Gln Ile Thr Met 
            580                 585                 590         


Gln Ser Thr Val Gln Leu Arg Thr Glu Tyr Asp Pro His Thr His Val 
        595                 600                 605             


Tyr Tyr Thr Thr Ala Glu Pro Arg Ser Glu Ile Ser Val Gln Pro Val 
    610                 615                 620                 


Thr Val Thr Gln Asp Thr Leu Ser Cys Gln Ser Pro Glu Ser Thr Ser 
625                 630                 635                 640 


Ser Thr Arg Asp Leu Leu Ser Gln Phe Ser Asp Ser Ser Leu His Cys 
                645                 650                 655     


Leu Glu Pro Pro Cys Thr Lys Trp Thr Leu Ser Ser Phe Ala Glu Lys 
            660                 665                 670         


His Tyr Ala Pro Phe Leu Leu Lys Pro Lys Ala Lys Val Val Val Ile 
        675                 680                 685             


Phe Leu Phe Leu Gly Leu Leu Gly Val Ser Leu Tyr Gly Thr Thr Arg 
    690                 695                 700                 


Val Arg Asp Gly Leu Asp Leu Thr Asp Ile Val Pro Arg Glu Thr Arg 
705                 710                 715                 720 


Glu Tyr Asp Phe Ile Ala Ala Gln Phe Lys Tyr Phe Ser Phe Tyr Asn 
                725                 730                 735     


Met Tyr Ile Val Thr Gln Lys Ala Asp Tyr Pro Asn Ile Gln His Leu 
            740                 745                 750         


Leu Tyr Asp Leu His Arg Ser Phe Ser Asn Val Lys Tyr Val Met Leu 
        755                 760                 765             


Glu Glu Asn Lys Gln Leu Pro Lys Met Trp Leu His Tyr Phe Arg Asp 
    770                 775                 780                 


Trp Leu Gln Gly Leu Gln Asp Ala Phe Asp Ser Asp Trp Glu Thr Gly 
785                 790                 795                 800 


Lys Ile Met Pro Asn Asn Tyr Lys Asn Gly Ser Asp Asp Gly Val Leu 
                805                 810                 815     


Ala Tyr Lys Leu Leu Val Gln Thr Gly Ser Arg Asp Lys Pro Ile Asp 
            820                 825                 830         


Ile Ser Gln Leu Thr Lys Gln Arg Leu Val Asp Ala Asp Gly Ile Ile 
        835                 840                 845             


Asn Pro Ser Ala Phe Tyr Ile Tyr Leu Thr Ala Trp Val Ser Asn Asp 
    850                 855                 860                 


Pro Val Ala Tyr Ala Ala Ser Gln Ala Asn Ile Arg Pro His Arg Pro 
865                 870                 875                 880 


Glu Trp Val His Asp Lys Ala Asp Tyr Met Pro Glu Thr Arg Leu Arg 
                885                 890                 895     


Ile Pro Ala Ala Glu Pro Ile Glu Tyr Ala Gln Phe Pro Phe Tyr Leu 
            900                 905                 910         


Asn Gly Leu Arg Asp Thr Ser Asp Phe Val Glu Ala Ile Glu Lys Val 
        915                 920                 925             


Arg Thr Ile Cys Ser Asn Tyr Thr Ser Leu Gly Leu Ser Ser Tyr Pro 
    930                 935                 940                 


Asn Gly Tyr Pro Phe Leu Phe Trp Glu Gln Tyr Ile Gly Leu Arg His 
945                 950                 955                 960 


Trp Leu Leu Leu Phe Ile Ser Val Val Leu Ala Cys Thr Phe Leu Val 
                965                 970                 975     


Cys Ala Val Phe Leu Leu Asn Pro Trp Thr Ala Gly Ile Ile Val Met 
            980                 985                 990         


Val Leu Ala Leu Met Thr Val Glu  Leu Phe Gly Met Met  Gly Leu Ile 
        995                 1000                 1005             


Gly Ile  Lys Leu Ser Ala Val  Pro Val Val Ile Leu  Ile Ala Ser 
    1010                 1015                 1020             


Val Gly  Ile Gly Val Glu Phe  Thr Val His Val Ala  Leu Ala Phe 
    1025                 1030                 1035             


Leu Thr  Ala Ile Gly Asp Lys  Asn Arg Arg Ala Val  Leu Ala Leu 
    1040                 1045                 1050             


Glu His  Met Phe Ala Pro Val  Leu Asp Gly Ala Val  Ser Thr Leu 
    1055                 1060                 1065             


Leu Gly  Val Leu Met Leu Ala  Gly Ser Glu Phe Asp  Phe Ile Val 
    1070                 1075                 1080             


Arg Tyr  Phe Phe Ala Val Leu  Ala Ile Leu Thr Ile  Leu Gly Val 
    1085                 1090                 1095             


Leu Asn  Gly Leu Val Leu Leu  Pro Val Leu Leu Ser  Phe Phe Gly 
    1100                 1105                 1110             


Pro Tyr  Pro Glu Val Ser Pro  Ala Asn Gly Leu Asn  Arg Leu Pro 
    1115                 1120                 1125             


Thr Pro  Ser Pro Glu Pro Pro  Pro Ser Val Val Arg  Phe Ala Met 
    1130                 1135                 1140             


Pro Pro  Gly His Thr His Ser  Gly Ser Asp Ser Ser  Asp Ser Glu 
    1145                 1150                 1155             


Tyr Ser  Ser Gln Thr Thr Val  Ser Gly Leu Ser Glu  Glu Leu Arg 
    1160                 1165                 1170             


His Tyr  Glu Ala Gln Gln Gly  Ala Gly Gly Pro Ala  His Gln Val 
    1175                 1180                 1185             


Ile Val  Glu Ala Thr Glu Asn  Pro Val Phe Ala His  Ser Thr Val 
    1190                 1195                 1200             


Val His  Pro Glu Ser Arg His  His Pro Pro Ser Asn  Pro Arg Gln 
    1205                 1210                 1215             


Gln Pro  His Leu Asp Ser Gly  Ser Leu Pro Pro Gly  Arg Gln Gly 
    1220                 1225                 1230             


Gln Gln  Pro Arg Arg Asp Pro  Pro Arg Glu Gly Leu  Trp Pro Pro 
    1235                 1240                 1245             


Pro Tyr  Arg Pro Arg Arg Asp  Ala Phe Glu Ile Ser  Thr Glu Gly 
    1250                 1255                 1260             


His Ser  Gly Pro Ser Asn Arg  Ala Arg Trp Gly Pro  Arg Gly Ala 
    1265                 1270                 1275             


Arg Ser  His Asn Pro Arg Asn  Pro Ala Ser Thr Ala  Met Gly Ser 
    1280                 1285                 1290             


Ser Val  Pro Gly Tyr Cys Gln  Pro Ile Thr Thr Val  Thr Ala Ser 
    1295                 1300                 1305             


Ala Ser  Val Thr Val Ala Val  His Pro Pro Pro Val  Pro Gly Pro 
    1310                 1315                 1320             


Gly Arg  Asn Pro Arg Gly Gly  Leu Cys Pro Gly Tyr  Pro Glu Thr 
    1325                 1330                 1335             


Asp His  Gly Leu Phe Glu Asp  Pro His Val Pro Phe  His Val Arg 
    1340                 1345                 1350             


Cys Glu  Arg Arg Asp Ser Lys  Val Glu Val Ile Glu  Leu Gln Asp 
    1355                 1360                 1365             


Val Glu  Cys Glu Glu Arg Pro  Arg Gly Ser Ser Ser  Asn 
    1370                 1375                 1380     


<210>  1072
<211>  1446
<212>  PRT
<213>  Homo sapiens

<400>  1072

Met Glu Leu Leu Asn Arg Asn Arg Leu Val Ile Val Ser Pro Arg Cys 
1               5                   10                  15      


Thr Pro Pro Lys Ala Ser Gly Gly Pro Ala Arg Arg Gly Phe Tyr Thr 
            20                  25                  30          


Phe Arg Ser Phe Cys Lys Asp Gly Gly Gly Gly Glu Glu Glu Glu Glu 
        35                  40                  45              


Asn Gly Gly Glu Glu Lys Asp Asp Arg Gly Asp Lys Glu Thr Arg Ser 
    50                  55                  60                  


Asp Lys Gly Lys Ala Thr Gly Arg Lys Ala Pro Leu Trp Leu Arg Ala 
65                  70                  75                  80  


Lys Phe Gln Arg Leu Leu Phe Lys Leu Gly Cys Tyr Ile Gln Lys Asn 
                85                  90                  95      


Cys Gly Lys Phe Leu Val Val Gly Leu Leu Ile Phe Gly Ala Phe Ala 
            100                 105                 110         


Val Gly Leu Lys Ala Ala Asn Leu Glu Thr Asn Val Glu Glu Leu Trp 
        115                 120                 125             


Val Glu Val Gly Gly Arg Val Ser Arg Glu Leu Asn Tyr Thr Arg Gln 
    130                 135                 140                 


Lys Ile Gly Glu Glu Ala Met Phe Asn Pro Gln Leu Met Ile Gln Thr 
145                 150                 155                 160 


Pro Lys Glu Glu Gly Ala Asn Val Leu Thr Thr Glu Ala Leu Leu Gln 
                165                 170                 175     


His Leu Asp Ser Ala Leu Gln Ala Ser Arg Val His Val Tyr Met Tyr 
            180                 185                 190         


Asn Arg Gln Trp Lys Leu Glu His Leu Cys Tyr Lys Ser Gly Glu Leu 
        195                 200                 205             


Ile Thr Glu Thr Gly Tyr Met Asp Gln Ile Ile Glu Tyr Leu Tyr Pro 
    210                 215                 220                 


Cys Leu Ile Ile Thr Pro Leu Asp Cys Phe Trp Glu Gly Ala Lys Leu 
225                 230                 235                 240 


Gln Ser Gly Thr Ala Tyr Leu Leu Gly Lys Pro Pro Leu Arg Trp Thr 
                245                 250                 255     


Asn Phe Asp Pro Leu Glu Phe Leu Glu Glu Leu Lys Lys Ile Asn Tyr 
            260                 265                 270         


Gln Val Asp Ser Trp Glu Glu Met Leu Asn Lys Ala Glu Val Gly His 
        275                 280                 285             


Gly Tyr Met Asp Arg Pro Cys Leu Asn Pro Ala Asp Pro Asp Cys Pro 
    290                 295                 300                 


Ala Thr Ala Pro Asn Lys Asn Ser Thr Lys Pro Leu Asp Met Ala Leu 
305                 310                 315                 320 


Val Leu Asn Gly Gly Cys His Gly Leu Ser Arg Lys Tyr Met His Trp 
                325                 330                 335     


Gln Glu Glu Leu Ile Val Gly Gly Thr Val Lys Asn Ser Thr Gly Lys 
            340                 345                 350         


Leu Val Ser Ala His Ala Leu Gln Thr Met Phe Gln Leu Met Thr Pro 
        355                 360                 365             


Lys Gln Met Tyr Glu His Phe Lys Gly Tyr Glu Tyr Val Ser His Ile 
    370                 375                 380                 


Asn Trp Asn Glu Asp Lys Ala Ala Ala Ile Leu Glu Ala Trp Gln Arg 
385                 390                 395                 400 


Thr Tyr Val Glu Val Val His Gln Ser Val Ala Gln Asn Ser Thr Gln 
                405                 410                 415     


Lys Val Leu Ser Phe Thr Thr Thr Thr Leu Asp Asp Ile Leu Lys Ser 
            420                 425                 430         


Phe Ser Asp Val Ser Val Ile Arg Val Ala Ser Gly Tyr Leu Leu Met 
        435                 440                 445             


Leu Ala Tyr Ala Cys Leu Thr Met Leu Arg Trp Asp Cys Ser Lys Ser 
    450                 455                 460                 


Gln Gly Ala Val Gly Leu Ala Gly Val Leu Leu Val Ala Leu Ser Val 
465                 470                 475                 480 


Ala Ala Gly Leu Gly Leu Cys Ser Leu Ile Gly Ile Ser Phe Asn Ala 
                485                 490                 495     


Ala Thr Thr Gln Val Leu Pro Phe Leu Ala Leu Gly Val Gly Val Asp 
            500                 505                 510         


Asp Val Phe Leu Leu Ala His Ala Phe Ser Glu Thr Gly Gln Asn Lys 
        515                 520                 525             


Arg Ile Pro Phe Glu Asp Arg Thr Gly Glu Cys Leu Lys Arg Thr Gly 
    530                 535                 540                 


Ala Ser Val Ala Leu Thr Ser Ile Ser Asn Val Thr Ala Phe Phe Met 
545                 550                 555                 560 


Ala Ala Leu Ile Pro Ile Pro Ala Leu Arg Ala Phe Ser Leu Gln Ala 
                565                 570                 575     


Ala Val Val Val Val Phe Asn Phe Ala Met Val Leu Leu Ile Phe Pro 
            580                 585                 590         


Ala Ile Leu Ser Met Asp Leu Tyr Arg Arg Glu Asp Arg Arg Leu Asp 
        595                 600                 605             


Ile Phe Cys Cys Phe Thr Ser Pro Cys Val Ser Arg Val Ile Gln Val 
    610                 615                 620                 


Glu Pro Gln Ala Tyr Thr Asp Thr His Asp Asn Thr Arg Tyr Ser Pro 
625                 630                 635                 640 


Pro Pro Pro Tyr Ser Ser His Ser Phe Ala His Glu Thr Gln Ile Thr 
                645                 650                 655     


Met Gln Ser Thr Val Gln Leu Arg Thr Glu Tyr Asp Pro His Thr His 
            660                 665                 670         


Val Tyr Tyr Thr Thr Ala Glu Pro Arg Ser Glu Ile Ser Val Gln Pro 
        675                 680                 685             


Val Thr Val Thr Gln Asp Thr Leu Ser Cys Gln Ser Pro Glu Ser Thr 
    690                 695                 700                 


Ser Ser Thr Arg Asp Leu Leu Ser Gln Phe Ser Asp Ser Ser Leu His 
705                 710                 715                 720 


Cys Leu Glu Pro Pro Cys Thr Lys Trp Thr Leu Ser Ser Phe Ala Glu 
                725                 730                 735     


Lys His Tyr Ala Pro Phe Leu Leu Lys Pro Lys Ala Lys Val Val Val 
            740                 745                 750         


Ile Phe Leu Phe Leu Gly Leu Leu Gly Val Ser Leu Tyr Gly Thr Thr 
        755                 760                 765             


Arg Val Arg Asp Gly Leu Asp Leu Thr Asp Ile Val Pro Arg Glu Thr 
    770                 775                 780                 


Arg Glu Tyr Asp Phe Ile Ala Ala Gln Phe Lys Tyr Phe Ser Phe Tyr 
785                 790                 795                 800 


Asn Met Tyr Ile Val Thr Gln Lys Ala Asp Tyr Pro Asn Ile Gln His 
                805                 810                 815     


Leu Leu Tyr Asp Leu His Arg Ser Phe Ser Asn Val Lys Tyr Val Met 
            820                 825                 830         


Leu Glu Glu Asn Lys Gln Leu Pro Lys Met Trp Leu His Tyr Phe Arg 
        835                 840                 845             


Asp Trp Leu Gln Gly Leu Gln Asp Ala Phe Asp Ser Asp Trp Glu Thr 
    850                 855                 860                 


Gly Lys Ile Met Pro Asn Asn Tyr Lys Asn Gly Ser Asp Asp Gly Val 
865                 870                 875                 880 


Leu Ala Tyr Lys Leu Leu Val Gln Thr Gly Ser Arg Asp Lys Pro Ile 
                885                 890                 895     


Asp Ile Ser Gln Leu Thr Lys Gln Arg Leu Val Asp Ala Asp Gly Ile 
            900                 905                 910         


Ile Asn Pro Ser Ala Phe Tyr Ile Tyr Leu Thr Ala Trp Val Ser Asn 
        915                 920                 925             


Asp Pro Val Ala Tyr Ala Ala Ser Gln Ala Asn Ile Arg Pro His Arg 
    930                 935                 940                 


Pro Glu Trp Val His Asp Lys Ala Asp Tyr Met Pro Glu Thr Arg Leu 
945                 950                 955                 960 


Arg Ile Pro Ala Ala Glu Pro Ile Glu Tyr Ala Gln Phe Pro Phe Tyr 
                965                 970                 975     


Leu Asn Gly Leu Arg Asp Thr Ser Asp Phe Val Glu Ala Ile Glu Lys 
            980                 985                 990         


Val Arg Thr Ile Cys Ser Asn Tyr  Thr Ser Leu Gly Leu  Ser Ser Tyr 
        995                 1000                 1005             


Pro Asn  Gly Tyr Pro Phe Leu  Phe Trp Glu Gln Tyr  Ile Gly Leu 
    1010                 1015                 1020             


Arg His  Trp Leu Leu Leu Phe  Ile Ser Val Val Leu  Ala Cys Thr 
    1025                 1030                 1035             


Phe Leu  Val Cys Ala Val Phe  Leu Leu Asn Pro Trp  Thr Ala Gly 
    1040                 1045                 1050             


Ile Ile  Val Met Val Leu Ala  Leu Met Thr Val Glu  Leu Phe Gly 
    1055                 1060                 1065             


Met Met  Gly Leu Ile Gly Ile  Lys Leu Ser Ala Val  Pro Val Val 
    1070                 1075                 1080             


Ile Leu  Ile Ala Ser Val Gly  Ile Gly Val Glu Phe  Thr Val His 
    1085                 1090                 1095             


Val Ala  Leu Ala Phe Leu Thr  Ala Ile Gly Asp Lys  Asn Arg Arg 
    1100                 1105                 1110             


Ala Val  Leu Ala Leu Glu His  Met Phe Ala Pro Val  Leu Asp Gly 
    1115                 1120                 1125             


Ala Val  Ser Thr Leu Leu Gly  Val Leu Met Leu Ala  Gly Ser Glu 
    1130                 1135                 1140             


Phe Asp  Phe Ile Val Arg Tyr  Phe Phe Ala Val Leu  Ala Ile Leu 
    1145                 1150                 1155             


Thr Ile  Leu Gly Val Leu Asn  Gly Leu Val Leu Leu  Pro Val Leu 
    1160                 1165                 1170             


Leu Ser  Phe Phe Gly Pro Tyr  Pro Glu Val Ser Pro  Ala Asn Gly 
    1175                 1180                 1185             


Leu Asn  Arg Leu Pro Thr Pro  Ser Pro Glu Pro Pro  Pro Ser Val 
    1190                 1195                 1200             


Val Arg  Phe Ala Met Pro Pro  Gly His Thr His Ser  Gly Ser Asp 
    1205                 1210                 1215             


Ser Ser  Asp Ser Glu Tyr Ser  Ser Gln Thr Thr Val  Ser Gly Leu 
    1220                 1225                 1230             


Ser Glu  Glu Leu Arg His Tyr  Glu Ala Gln Gln Gly  Ala Gly Gly 
    1235                 1240                 1245             


Pro Ala  His Gln Val Ile Val  Glu Ala Thr Glu Asn  Pro Val Phe 
    1250                 1255                 1260             


Ala His  Ser Thr Val Val His  Pro Glu Ser Arg His  His Pro Pro 
    1265                 1270                 1275             


Ser Asn  Pro Arg Gln Gln Pro  His Leu Asp Ser Gly  Ser Leu Pro 
    1280                 1285                 1290             


Pro Gly  Arg Gln Gly Gln Gln  Pro Arg Arg Asp Pro  Pro Arg Glu 
    1295                 1300                 1305             


Gly Leu  Trp Pro Pro Pro Tyr  Arg Pro Arg Arg Asp  Ala Phe Glu 
    1310                 1315                 1320             


Ile Ser  Thr Glu Gly His Ser  Gly Pro Ser Asn Arg  Ala Arg Trp 
    1325                 1330                 1335             


Gly Pro  Arg Gly Ala Arg Ser  His Asn Pro Arg Asn  Pro Ala Ser 
    1340                 1345                 1350             


Thr Ala  Met Gly Ser Ser Val  Pro Gly Tyr Cys Gln  Pro Ile Thr 
    1355                 1360                 1365             


Thr Val  Thr Ala Ser Ala Ser  Val Thr Val Ala Val  His Pro Pro 
    1370                 1375                 1380             


Pro Val  Pro Gly Pro Gly Arg  Asn Pro Arg Gly Gly  Leu Cys Pro 
    1385                 1390                 1395             


Gly Tyr  Pro Glu Thr Asp His  Gly Leu Phe Glu Asp  Pro His Val 
    1400                 1405                 1410             


Pro Phe  His Val Arg Cys Glu  Arg Arg Asp Ser Lys  Val Glu Val 
    1415                 1420                 1425             


Ile Glu  Leu Gln Asp Val Glu  Cys Glu Glu Arg Pro  Arg Gly Ser 
    1430                 1435                 1440             


Ser Ser  Asn 
    1445     


<210>  1073
<211>  1296
<212>  PRT
<213>  Homo sapiens

<400>  1073

Met Phe Asn Pro Gln Leu Met Ile Gln Thr Pro Lys Glu Glu Gly Ala 
1               5                   10                  15      


Asn Val Leu Thr Thr Glu Ala Leu Leu Gln His Leu Asp Ser Ala Leu 
            20                  25                  30          


Gln Ala Ser Arg Val His Val Tyr Met Tyr Asn Arg Gln Trp Lys Leu 
        35                  40                  45              


Glu His Leu Cys Tyr Lys Ser Gly Glu Leu Ile Thr Glu Thr Gly Tyr 
    50                  55                  60                  


Met Asp Gln Ile Ile Glu Tyr Leu Tyr Pro Cys Leu Ile Ile Thr Pro 
65                  70                  75                  80  


Leu Asp Cys Phe Trp Glu Gly Ala Lys Leu Gln Ser Gly Thr Ala Tyr 
                85                  90                  95      


Leu Leu Gly Lys Pro Pro Leu Arg Trp Thr Asn Phe Asp Pro Leu Glu 
            100                 105                 110         


Phe Leu Glu Glu Leu Lys Lys Ile Asn Tyr Gln Val Asp Ser Trp Glu 
        115                 120                 125             


Glu Met Leu Asn Lys Ala Glu Val Gly His Gly Tyr Met Asp Arg Pro 
    130                 135                 140                 


Cys Leu Asn Pro Ala Asp Pro Asp Cys Pro Ala Thr Ala Pro Asn Lys 
145                 150                 155                 160 


Asn Ser Thr Lys Pro Leu Asp Met Ala Leu Val Leu Asn Gly Gly Cys 
                165                 170                 175     


His Gly Leu Ser Arg Lys Tyr Met His Trp Gln Glu Glu Leu Ile Val 
            180                 185                 190         


Gly Gly Thr Val Lys Asn Ser Thr Gly Lys Leu Val Ser Ala His Ala 
        195                 200                 205             


Leu Gln Thr Met Phe Gln Leu Met Thr Pro Lys Gln Met Tyr Glu His 
    210                 215                 220                 


Phe Lys Gly Tyr Glu Tyr Val Ser His Ile Asn Trp Asn Glu Asp Lys 
225                 230                 235                 240 


Ala Ala Ala Ile Leu Glu Ala Trp Gln Arg Thr Tyr Val Glu Val Val 
                245                 250                 255     


His Gln Ser Val Ala Gln Asn Ser Thr Gln Lys Val Leu Ser Phe Thr 
            260                 265                 270         


Thr Thr Thr Leu Asp Asp Ile Leu Lys Ser Phe Ser Asp Val Ser Val 
        275                 280                 285             


Ile Arg Val Ala Ser Gly Tyr Leu Leu Met Leu Ala Tyr Ala Cys Leu 
    290                 295                 300                 


Thr Met Leu Arg Trp Asp Cys Ser Lys Ser Gln Gly Ala Val Gly Leu 
305                 310                 315                 320 


Ala Gly Val Leu Leu Val Ala Leu Ser Val Ala Ala Gly Leu Gly Leu 
                325                 330                 335     


Cys Ser Leu Ile Gly Ile Ser Phe Asn Ala Ala Thr Thr Gln Val Leu 
            340                 345                 350         


Pro Phe Leu Ala Leu Gly Val Gly Val Asp Asp Val Phe Leu Leu Ala 
        355                 360                 365             


His Ala Phe Ser Glu Thr Gly Gln Asn Lys Arg Ile Pro Phe Glu Asp 
    370                 375                 380                 


Arg Thr Gly Glu Cys Leu Lys Arg Thr Gly Ala Ser Val Ala Leu Thr 
385                 390                 395                 400 


Ser Ile Ser Asn Val Thr Ala Phe Phe Met Ala Ala Leu Ile Pro Ile 
                405                 410                 415     


Pro Ala Leu Arg Ala Phe Ser Leu Gln Ala Ala Val Val Val Val Phe 
            420                 425                 430         


Asn Phe Ala Met Val Leu Leu Ile Phe Pro Ala Ile Leu Ser Met Asp 
        435                 440                 445             


Leu Tyr Arg Arg Glu Asp Arg Arg Leu Asp Ile Phe Cys Cys Phe Thr 
    450                 455                 460                 


Ser Pro Cys Val Ser Arg Val Ile Gln Val Glu Pro Gln Ala Tyr Thr 
465                 470                 475                 480 


Asp Thr His Asp Asn Thr Arg Tyr Ser Pro Pro Pro Pro Tyr Ser Ser 
                485                 490                 495     


His Ser Phe Ala His Glu Thr Gln Ile Thr Met Gln Ser Thr Val Gln 
            500                 505                 510         


Leu Arg Thr Glu Tyr Asp Pro His Thr His Val Tyr Tyr Thr Thr Ala 
        515                 520                 525             


Glu Pro Arg Ser Glu Ile Ser Val Gln Pro Val Thr Val Thr Gln Asp 
    530                 535                 540                 


Thr Leu Ser Cys Gln Ser Pro Glu Ser Thr Ser Ser Thr Arg Asp Leu 
545                 550                 555                 560 


Leu Ser Gln Phe Ser Asp Ser Ser Leu His Cys Leu Glu Pro Pro Cys 
                565                 570                 575     


Thr Lys Trp Thr Leu Ser Ser Phe Ala Glu Lys His Tyr Ala Pro Phe 
            580                 585                 590         


Leu Leu Lys Pro Lys Ala Lys Val Val Val Ile Phe Leu Phe Leu Gly 
        595                 600                 605             


Leu Leu Gly Val Ser Leu Tyr Gly Thr Thr Arg Val Arg Asp Gly Leu 
    610                 615                 620                 


Asp Leu Thr Asp Ile Val Pro Arg Glu Thr Arg Glu Tyr Asp Phe Ile 
625                 630                 635                 640 


Ala Ala Gln Phe Lys Tyr Phe Ser Phe Tyr Asn Met Tyr Ile Val Thr 
                645                 650                 655     


Gln Lys Ala Asp Tyr Pro Asn Ile Gln His Leu Leu Tyr Asp Leu His 
            660                 665                 670         


Arg Ser Phe Ser Asn Val Lys Tyr Val Met Leu Glu Glu Asn Lys Gln 
        675                 680                 685             


Leu Pro Lys Met Trp Leu His Tyr Phe Arg Asp Trp Leu Gln Gly Leu 
    690                 695                 700                 


Gln Asp Ala Phe Asp Ser Asp Trp Glu Thr Gly Lys Ile Met Pro Asn 
705                 710                 715                 720 


Asn Tyr Lys Asn Gly Ser Asp Asp Gly Val Leu Ala Tyr Lys Leu Leu 
                725                 730                 735     


Val Gln Thr Gly Ser Arg Asp Lys Pro Ile Asp Ile Ser Gln Leu Thr 
            740                 745                 750         


Lys Gln Arg Leu Val Asp Ala Asp Gly Ile Ile Asn Pro Ser Ala Phe 
        755                 760                 765             


Tyr Ile Tyr Leu Thr Ala Trp Val Ser Asn Asp Pro Val Ala Tyr Ala 
    770                 775                 780                 


Ala Ser Gln Ala Asn Ile Arg Pro His Arg Pro Glu Trp Val His Asp 
785                 790                 795                 800 


Lys Ala Asp Tyr Met Pro Glu Thr Arg Leu Arg Ile Pro Ala Ala Glu 
                805                 810                 815     


Pro Ile Glu Tyr Ala Gln Phe Pro Phe Tyr Leu Asn Gly Leu Arg Asp 
            820                 825                 830         


Thr Ser Asp Phe Val Glu Ala Ile Glu Lys Val Arg Thr Ile Cys Ser 
        835                 840                 845             


Asn Tyr Thr Ser Leu Gly Leu Ser Ser Tyr Pro Asn Gly Tyr Pro Phe 
    850                 855                 860                 


Leu Phe Trp Glu Gln Tyr Ile Gly Leu Arg His Trp Leu Leu Leu Phe 
865                 870                 875                 880 


Ile Ser Val Val Leu Ala Cys Thr Phe Leu Val Cys Ala Val Phe Leu 
                885                 890                 895     


Leu Asn Pro Trp Thr Ala Gly Ile Ile Val Met Val Leu Ala Leu Met 
            900                 905                 910         


Thr Val Glu Leu Phe Gly Met Met Gly Leu Ile Gly Ile Lys Leu Ser 
        915                 920                 925             


Ala Val Pro Val Val Ile Leu Ile Ala Ser Val Gly Ile Gly Val Glu 
    930                 935                 940                 


Phe Thr Val His Val Ala Leu Ala Phe Leu Thr Ala Ile Gly Asp Lys 
945                 950                 955                 960 


Asn Arg Arg Ala Val Leu Ala Leu Glu His Met Phe Ala Pro Val Leu 
                965                 970                 975     


Asp Gly Ala Val Ser Thr Leu Leu Gly Val Leu Met Leu Ala Gly Ser 
            980                 985                 990         


Glu Phe Asp Phe Ile Val Arg Tyr  Phe Phe Ala Val Leu  Ala Ile Leu 
        995                 1000                 1005             


Thr Ile  Leu Gly Val Leu Asn  Gly Leu Val Leu Leu  Pro Val Leu 
    1010                 1015                 1020             


Leu Ser  Phe Phe Gly Pro Tyr  Pro Glu Val Ser Pro  Ala Asn Gly 
    1025                 1030                 1035             


Leu Asn  Arg Leu Pro Thr Pro  Ser Pro Glu Pro Pro  Pro Ser Val 
    1040                 1045                 1050             


Val Arg  Phe Ala Met Pro Pro  Gly His Thr His Ser  Gly Ser Asp 
    1055                 1060                 1065             


Ser Ser  Asp Ser Glu Tyr Ser  Ser Gln Thr Thr Val  Ser Gly Leu 
    1070                 1075                 1080             


Ser Glu  Glu Leu Arg His Tyr  Glu Ala Gln Gln Gly  Ala Gly Gly 
    1085                 1090                 1095             


Pro Ala  His Gln Val Ile Val  Glu Ala Thr Glu Asn  Pro Val Phe 
    1100                 1105                 1110             


Ala His  Ser Thr Val Val His  Pro Glu Ser Arg His  His Pro Pro 
    1115                 1120                 1125             


Ser Asn  Pro Arg Gln Gln Pro  His Leu Asp Ser Gly  Ser Leu Pro 
    1130                 1135                 1140             


Pro Gly  Arg Gln Gly Gln Gln  Pro Arg Arg Asp Pro  Pro Arg Glu 
    1145                 1150                 1155             


Gly Leu  Trp Pro Pro Pro Tyr  Arg Pro Arg Arg Asp  Ala Phe Glu 
    1160                 1165                 1170             


Ile Ser  Thr Glu Gly His Ser  Gly Pro Ser Asn Arg  Ala Arg Trp 
    1175                 1180                 1185             


Gly Pro  Arg Gly Ala Arg Ser  His Asn Pro Arg Asn  Pro Ala Ser 
    1190                 1195                 1200             


Thr Ala  Met Gly Ser Ser Val  Pro Gly Tyr Cys Gln  Pro Ile Thr 
    1205                 1210                 1215             


Thr Val  Thr Ala Ser Ala Ser  Val Thr Val Ala Val  His Pro Pro 
    1220                 1225                 1230             


Pro Val  Pro Gly Pro Gly Arg  Asn Pro Arg Gly Gly  Leu Cys Pro 
    1235                 1240                 1245             


Gly Tyr  Pro Glu Thr Asp His  Gly Leu Phe Glu Asp  Pro His Val 
    1250                 1255                 1260             


Pro Phe  His Val Arg Cys Glu  Arg Arg Asp Ser Lys  Val Glu Val 
    1265                 1270                 1275             


Ile Glu  Leu Gln Asp Val Glu  Cys Glu Glu Arg Pro  Arg Gly Ser 
    1280                 1285                 1290             


Ser Ser  Asn 
    1295     


<210>  1074
<211>  1296
<212>  PRT
<213>  Homo sapiens

<400>  1074

Met Phe Asn Pro Gln Leu Met Ile Gln Thr Pro Lys Glu Glu Gly Ala 
1               5                   10                  15      


Asn Val Leu Thr Thr Glu Ala Leu Leu Gln His Leu Asp Ser Ala Leu 
            20                  25                  30          


Gln Ala Ser Arg Val His Val Tyr Met Tyr Asn Arg Gln Trp Lys Leu 
        35                  40                  45              


Glu His Leu Cys Tyr Lys Ser Gly Glu Leu Ile Thr Glu Thr Gly Tyr 
    50                  55                  60                  


Met Asp Gln Ile Ile Glu Tyr Leu Tyr Pro Cys Leu Ile Ile Thr Pro 
65                  70                  75                  80  


Leu Asp Cys Phe Trp Glu Gly Ala Lys Leu Gln Ser Gly Thr Ala Tyr 
                85                  90                  95      


Leu Leu Gly Lys Pro Pro Leu Arg Trp Thr Asn Phe Asp Pro Leu Glu 
            100                 105                 110         


Phe Leu Glu Glu Leu Lys Lys Ile Asn Tyr Gln Val Asp Ser Trp Glu 
        115                 120                 125             


Glu Met Leu Asn Lys Ala Glu Val Gly His Gly Tyr Met Asp Arg Pro 
    130                 135                 140                 


Cys Leu Asn Pro Ala Asp Pro Asp Cys Pro Ala Thr Ala Pro Asn Lys 
145                 150                 155                 160 


Asn Ser Thr Lys Pro Leu Asp Met Ala Leu Val Leu Asn Gly Gly Cys 
                165                 170                 175     


His Gly Leu Ser Arg Lys Tyr Met His Trp Gln Glu Glu Leu Ile Val 
            180                 185                 190         


Gly Gly Thr Val Lys Asn Ser Thr Gly Lys Leu Val Ser Ala His Ala 
        195                 200                 205             


Leu Gln Thr Met Phe Gln Leu Met Thr Pro Lys Gln Met Tyr Glu His 
    210                 215                 220                 


Phe Lys Gly Tyr Glu Tyr Val Ser His Ile Asn Trp Asn Glu Asp Lys 
225                 230                 235                 240 


Ala Ala Ala Ile Leu Glu Ala Trp Gln Arg Thr Tyr Val Glu Val Val 
                245                 250                 255     


His Gln Ser Val Ala Gln Asn Ser Thr Gln Lys Val Leu Ser Phe Thr 
            260                 265                 270         


Thr Thr Thr Leu Asp Asp Ile Leu Lys Ser Phe Ser Asp Val Ser Val 
        275                 280                 285             


Ile Arg Val Ala Ser Gly Tyr Leu Leu Met Leu Ala Tyr Ala Cys Leu 
    290                 295                 300                 


Thr Met Leu Arg Trp Asp Cys Ser Lys Ser Gln Gly Ala Val Gly Leu 
305                 310                 315                 320 


Ala Gly Val Leu Leu Val Ala Leu Ser Val Ala Ala Gly Leu Gly Leu 
                325                 330                 335     


Cys Ser Leu Ile Gly Ile Ser Phe Asn Ala Ala Thr Thr Gln Val Leu 
            340                 345                 350         


Pro Phe Leu Ala Leu Gly Val Gly Val Asp Asp Val Phe Leu Leu Ala 
        355                 360                 365             


His Ala Phe Ser Glu Thr Gly Gln Asn Lys Arg Ile Pro Phe Glu Asp 
    370                 375                 380                 


Arg Thr Gly Glu Cys Leu Lys Arg Thr Gly Ala Ser Val Ala Leu Thr 
385                 390                 395                 400 


Ser Ile Ser Asn Val Thr Ala Phe Phe Met Ala Ala Leu Ile Pro Ile 
                405                 410                 415     


Pro Ala Leu Arg Ala Phe Ser Leu Gln Ala Ala Val Val Val Val Phe 
            420                 425                 430         


Asn Phe Ala Met Val Leu Leu Ile Phe Pro Ala Ile Leu Ser Met Asp 
        435                 440                 445             


Leu Tyr Arg Arg Glu Asp Arg Arg Leu Asp Ile Phe Cys Cys Phe Thr 
    450                 455                 460                 


Ser Pro Cys Val Ser Arg Val Ile Gln Val Glu Pro Gln Ala Tyr Thr 
465                 470                 475                 480 


Asp Thr His Asp Asn Thr Arg Tyr Ser Pro Pro Pro Pro Tyr Ser Ser 
                485                 490                 495     


His Ser Phe Ala His Glu Thr Gln Ile Thr Met Gln Ser Thr Val Gln 
            500                 505                 510         


Leu Arg Thr Glu Tyr Asp Pro His Thr His Val Tyr Tyr Thr Thr Ala 
        515                 520                 525             


Glu Pro Arg Ser Glu Ile Ser Val Gln Pro Val Thr Val Thr Gln Asp 
    530                 535                 540                 


Thr Leu Ser Cys Gln Ser Pro Glu Ser Thr Ser Ser Thr Arg Asp Leu 
545                 550                 555                 560 


Leu Ser Gln Phe Ser Asp Ser Ser Leu His Cys Leu Glu Pro Pro Cys 
                565                 570                 575     


Thr Lys Trp Thr Leu Ser Ser Phe Ala Glu Lys His Tyr Ala Pro Phe 
            580                 585                 590         


Leu Leu Lys Pro Lys Ala Lys Val Val Val Ile Phe Leu Phe Leu Gly 
        595                 600                 605             


Leu Leu Gly Val Ser Leu Tyr Gly Thr Thr Arg Val Arg Asp Gly Leu 
    610                 615                 620                 


Asp Leu Thr Asp Ile Val Pro Arg Glu Thr Arg Glu Tyr Asp Phe Ile 
625                 630                 635                 640 


Ala Ala Gln Phe Lys Tyr Phe Ser Phe Tyr Asn Met Tyr Ile Val Thr 
                645                 650                 655     


Gln Lys Ala Asp Tyr Pro Asn Ile Gln His Leu Leu Tyr Asp Leu His 
            660                 665                 670         


Arg Ser Phe Ser Asn Val Lys Tyr Val Met Leu Glu Glu Asn Lys Gln 
        675                 680                 685             


Leu Pro Lys Met Trp Leu His Tyr Phe Arg Asp Trp Leu Gln Gly Leu 
    690                 695                 700                 


Gln Asp Ala Phe Asp Ser Asp Trp Glu Thr Gly Lys Ile Met Pro Asn 
705                 710                 715                 720 


Asn Tyr Lys Asn Gly Ser Asp Asp Gly Val Leu Ala Tyr Lys Leu Leu 
                725                 730                 735     


Val Gln Thr Gly Ser Arg Asp Lys Pro Ile Asp Ile Ser Gln Leu Thr 
            740                 745                 750         


Lys Gln Arg Leu Val Asp Ala Asp Gly Ile Ile Asn Pro Ser Ala Phe 
        755                 760                 765             


Tyr Ile Tyr Leu Thr Ala Trp Val Ser Asn Asp Pro Val Ala Tyr Ala 
    770                 775                 780                 


Ala Ser Gln Ala Asn Ile Arg Pro His Arg Pro Glu Trp Val His Asp 
785                 790                 795                 800 


Lys Ala Asp Tyr Met Pro Glu Thr Arg Leu Arg Ile Pro Ala Ala Glu 
                805                 810                 815     


Pro Ile Glu Tyr Ala Gln Phe Pro Phe Tyr Leu Asn Gly Leu Arg Asp 
            820                 825                 830         


Thr Ser Asp Phe Val Glu Ala Ile Glu Lys Val Arg Thr Ile Cys Ser 
        835                 840                 845             


Asn Tyr Thr Ser Leu Gly Leu Ser Ser Tyr Pro Asn Gly Tyr Pro Phe 
    850                 855                 860                 


Leu Phe Trp Glu Gln Tyr Ile Gly Leu Arg His Trp Leu Leu Leu Phe 
865                 870                 875                 880 


Ile Ser Val Val Leu Ala Cys Thr Phe Leu Val Cys Ala Val Phe Leu 
                885                 890                 895     


Leu Asn Pro Trp Thr Ala Gly Ile Ile Val Met Val Leu Ala Leu Met 
            900                 905                 910         


Thr Val Glu Leu Phe Gly Met Met Gly Leu Ile Gly Ile Lys Leu Ser 
        915                 920                 925             


Ala Val Pro Val Val Ile Leu Ile Ala Ser Val Gly Ile Gly Val Glu 
    930                 935                 940                 


Phe Thr Val His Val Ala Leu Ala Phe Leu Thr Ala Ile Gly Asp Lys 
945                 950                 955                 960 


Asn Arg Arg Ala Val Leu Ala Leu Glu His Met Phe Ala Pro Val Leu 
                965                 970                 975     


Asp Gly Ala Val Ser Thr Leu Leu Gly Val Leu Met Leu Ala Gly Ser 
            980                 985                 990         


Glu Phe Asp Phe Ile Val Arg Tyr  Phe Phe Ala Val Leu  Ala Ile Leu 
        995                 1000                 1005             


Thr Ile  Leu Gly Val Leu Asn  Gly Leu Val Leu Leu  Pro Val Leu 
    1010                 1015                 1020             


Leu Ser  Phe Phe Gly Pro Tyr  Pro Glu Val Ser Pro  Ala Asn Gly 
    1025                 1030                 1035             


Leu Asn  Arg Leu Pro Thr Pro  Ser Pro Glu Pro Pro  Pro Ser Val 
    1040                 1045                 1050             


Val Arg  Phe Ala Met Pro Pro  Gly His Thr His Ser  Gly Ser Asp 
    1055                 1060                 1065             


Ser Ser  Asp Ser Glu Tyr Ser  Ser Gln Thr Thr Val  Ser Gly Leu 
    1070                 1075                 1080             


Ser Glu  Glu Leu Arg His Tyr  Glu Ala Gln Gln Gly  Ala Gly Gly 
    1085                 1090                 1095             


Pro Ala  His Gln Val Ile Val  Glu Ala Thr Glu Asn  Pro Val Phe 
    1100                 1105                 1110             


Ala His  Ser Thr Val Val His  Pro Glu Ser Arg His  His Pro Pro 
    1115                 1120                 1125             


Ser Asn  Pro Arg Gln Gln Pro  His Leu Asp Ser Gly  Ser Leu Pro 
    1130                 1135                 1140             


Pro Gly  Arg Gln Gly Gln Gln  Pro Arg Arg Asp Pro  Pro Arg Glu 
    1145                 1150                 1155             


Gly Leu  Trp Pro Pro Pro Tyr  Arg Pro Arg Arg Asp  Ala Phe Glu 
    1160                 1165                 1170             


Ile Ser  Thr Glu Gly His Ser  Gly Pro Ser Asn Arg  Ala Arg Trp 
    1175                 1180                 1185             


Gly Pro  Arg Gly Ala Arg Ser  His Asn Pro Arg Asn  Pro Ala Ser 
    1190                 1195                 1200             


Thr Ala  Met Gly Ser Ser Val  Pro Gly Tyr Cys Gln  Pro Ile Thr 
    1205                 1210                 1215             


Thr Val  Thr Ala Ser Ala Ser  Val Thr Val Ala Val  His Pro Pro 
    1220                 1225                 1230             


Pro Val  Pro Gly Pro Gly Arg  Asn Pro Arg Gly Gly  Leu Cys Pro 
    1235                 1240                 1245             


Gly Tyr  Pro Glu Thr Asp His  Gly Leu Phe Glu Asp  Pro His Val 
    1250                 1255                 1260             


Pro Phe  His Val Arg Cys Glu  Arg Arg Asp Ser Lys  Val Glu Val 
    1265                 1270                 1275             


Ile Glu  Leu Gln Asp Val Glu  Cys Glu Glu Arg Pro  Arg Gly Ser 
    1280                 1285                 1290             


Ser Ser  Asn 
    1295     


<210>  1075
<211>  1296
<212>  PRT
<213>  Homo sapiens

<400>  1075

Met Phe Asn Pro Gln Leu Met Ile Gln Thr Pro Lys Glu Glu Gly Ala 
1               5                   10                  15      


Asn Val Leu Thr Thr Glu Ala Leu Leu Gln His Leu Asp Ser Ala Leu 
            20                  25                  30          


Gln Ala Ser Arg Val His Val Tyr Met Tyr Asn Arg Gln Trp Lys Leu 
        35                  40                  45              


Glu His Leu Cys Tyr Lys Ser Gly Glu Leu Ile Thr Glu Thr Gly Tyr 
    50                  55                  60                  


Met Asp Gln Ile Ile Glu Tyr Leu Tyr Pro Cys Leu Ile Ile Thr Pro 
65                  70                  75                  80  


Leu Asp Cys Phe Trp Glu Gly Ala Lys Leu Gln Ser Gly Thr Ala Tyr 
                85                  90                  95      


Leu Leu Gly Lys Pro Pro Leu Arg Trp Thr Asn Phe Asp Pro Leu Glu 
            100                 105                 110         


Phe Leu Glu Glu Leu Lys Lys Ile Asn Tyr Gln Val Asp Ser Trp Glu 
        115                 120                 125             


Glu Met Leu Asn Lys Ala Glu Val Gly His Gly Tyr Met Asp Arg Pro 
    130                 135                 140                 


Cys Leu Asn Pro Ala Asp Pro Asp Cys Pro Ala Thr Ala Pro Asn Lys 
145                 150                 155                 160 


Asn Ser Thr Lys Pro Leu Asp Met Ala Leu Val Leu Asn Gly Gly Cys 
                165                 170                 175     


His Gly Leu Ser Arg Lys Tyr Met His Trp Gln Glu Glu Leu Ile Val 
            180                 185                 190         


Gly Gly Thr Val Lys Asn Ser Thr Gly Lys Leu Val Ser Ala His Ala 
        195                 200                 205             


Leu Gln Thr Met Phe Gln Leu Met Thr Pro Lys Gln Met Tyr Glu His 
    210                 215                 220                 


Phe Lys Gly Tyr Glu Tyr Val Ser His Ile Asn Trp Asn Glu Asp Lys 
225                 230                 235                 240 


Ala Ala Ala Ile Leu Glu Ala Trp Gln Arg Thr Tyr Val Glu Val Val 
                245                 250                 255     


His Gln Ser Val Ala Gln Asn Ser Thr Gln Lys Val Leu Ser Phe Thr 
            260                 265                 270         


Thr Thr Thr Leu Asp Asp Ile Leu Lys Ser Phe Ser Asp Val Ser Val 
        275                 280                 285             


Ile Arg Val Ala Ser Gly Tyr Leu Leu Met Leu Ala Tyr Ala Cys Leu 
    290                 295                 300                 


Thr Met Leu Arg Trp Asp Cys Ser Lys Ser Gln Gly Ala Val Gly Leu 
305                 310                 315                 320 


Ala Gly Val Leu Leu Val Ala Leu Ser Val Ala Ala Gly Leu Gly Leu 
                325                 330                 335     


Cys Ser Leu Ile Gly Ile Ser Phe Asn Ala Ala Thr Thr Gln Val Leu 
            340                 345                 350         


Pro Phe Leu Ala Leu Gly Val Gly Val Asp Asp Val Phe Leu Leu Ala 
        355                 360                 365             


His Ala Phe Ser Glu Thr Gly Gln Asn Lys Arg Ile Pro Phe Glu Asp 
    370                 375                 380                 


Arg Thr Gly Glu Cys Leu Lys Arg Thr Gly Ala Ser Val Ala Leu Thr 
385                 390                 395                 400 


Ser Ile Ser Asn Val Thr Ala Phe Phe Met Ala Ala Leu Ile Pro Ile 
                405                 410                 415     


Pro Ala Leu Arg Ala Phe Ser Leu Gln Ala Ala Val Val Val Val Phe 
            420                 425                 430         


Asn Phe Ala Met Val Leu Leu Ile Phe Pro Ala Ile Leu Ser Met Asp 
        435                 440                 445             


Leu Tyr Arg Arg Glu Asp Arg Arg Leu Asp Ile Phe Cys Cys Phe Thr 
    450                 455                 460                 


Ser Pro Cys Val Ser Arg Val Ile Gln Val Glu Pro Gln Ala Tyr Thr 
465                 470                 475                 480 


Asp Thr His Asp Asn Thr Arg Tyr Ser Pro Pro Pro Pro Tyr Ser Ser 
                485                 490                 495     


His Ser Phe Ala His Glu Thr Gln Ile Thr Met Gln Ser Thr Val Gln 
            500                 505                 510         


Leu Arg Thr Glu Tyr Asp Pro His Thr His Val Tyr Tyr Thr Thr Ala 
        515                 520                 525             


Glu Pro Arg Ser Glu Ile Ser Val Gln Pro Val Thr Val Thr Gln Asp 
    530                 535                 540                 


Thr Leu Ser Cys Gln Ser Pro Glu Ser Thr Ser Ser Thr Arg Asp Leu 
545                 550                 555                 560 


Leu Ser Gln Phe Ser Asp Ser Ser Leu His Cys Leu Glu Pro Pro Cys 
                565                 570                 575     


Thr Lys Trp Thr Leu Ser Ser Phe Ala Glu Lys His Tyr Ala Pro Phe 
            580                 585                 590         


Leu Leu Lys Pro Lys Ala Lys Val Val Val Ile Phe Leu Phe Leu Gly 
        595                 600                 605             


Leu Leu Gly Val Ser Leu Tyr Gly Thr Thr Arg Val Arg Asp Gly Leu 
    610                 615                 620                 


Asp Leu Thr Asp Ile Val Pro Arg Glu Thr Arg Glu Tyr Asp Phe Ile 
625                 630                 635                 640 


Ala Ala Gln Phe Lys Tyr Phe Ser Phe Tyr Asn Met Tyr Ile Val Thr 
                645                 650                 655     


Gln Lys Ala Asp Tyr Pro Asn Ile Gln His Leu Leu Tyr Asp Leu His 
            660                 665                 670         


Arg Ser Phe Ser Asn Val Lys Tyr Val Met Leu Glu Glu Asn Lys Gln 
        675                 680                 685             


Leu Pro Lys Met Trp Leu His Tyr Phe Arg Asp Trp Leu Gln Gly Leu 
    690                 695                 700                 


Gln Asp Ala Phe Asp Ser Asp Trp Glu Thr Gly Lys Ile Met Pro Asn 
705                 710                 715                 720 


Asn Tyr Lys Asn Gly Ser Asp Asp Gly Val Leu Ala Tyr Lys Leu Leu 
                725                 730                 735     


Val Gln Thr Gly Ser Arg Asp Lys Pro Ile Asp Ile Ser Gln Leu Thr 
            740                 745                 750         


Lys Gln Arg Leu Val Asp Ala Asp Gly Ile Ile Asn Pro Ser Ala Phe 
        755                 760                 765             


Tyr Ile Tyr Leu Thr Ala Trp Val Ser Asn Asp Pro Val Ala Tyr Ala 
    770                 775                 780                 


Ala Ser Gln Ala Asn Ile Arg Pro His Arg Pro Glu Trp Val His Asp 
785                 790                 795                 800 


Lys Ala Asp Tyr Met Pro Glu Thr Arg Leu Arg Ile Pro Ala Ala Glu 
                805                 810                 815     


Pro Ile Glu Tyr Ala Gln Phe Pro Phe Tyr Leu Asn Gly Leu Arg Asp 
            820                 825                 830         


Thr Ser Asp Phe Val Glu Ala Ile Glu Lys Val Arg Thr Ile Cys Ser 
        835                 840                 845             


Asn Tyr Thr Ser Leu Gly Leu Ser Ser Tyr Pro Asn Gly Tyr Pro Phe 
    850                 855                 860                 


Leu Phe Trp Glu Gln Tyr Ile Gly Leu Arg His Trp Leu Leu Leu Phe 
865                 870                 875                 880 


Ile Ser Val Val Leu Ala Cys Thr Phe Leu Val Cys Ala Val Phe Leu 
                885                 890                 895     


Leu Asn Pro Trp Thr Ala Gly Ile Ile Val Met Val Leu Ala Leu Met 
            900                 905                 910         


Thr Val Glu Leu Phe Gly Met Met Gly Leu Ile Gly Ile Lys Leu Ser 
        915                 920                 925             


Ala Val Pro Val Val Ile Leu Ile Ala Ser Val Gly Ile Gly Val Glu 
    930                 935                 940                 


Phe Thr Val His Val Ala Leu Ala Phe Leu Thr Ala Ile Gly Asp Lys 
945                 950                 955                 960 


Asn Arg Arg Ala Val Leu Ala Leu Glu His Met Phe Ala Pro Val Leu 
                965                 970                 975     


Asp Gly Ala Val Ser Thr Leu Leu Gly Val Leu Met Leu Ala Gly Ser 
            980                 985                 990         


Glu Phe Asp Phe Ile Val Arg Tyr  Phe Phe Ala Val Leu  Ala Ile Leu 
        995                 1000                 1005             


Thr Ile  Leu Gly Val Leu Asn  Gly Leu Val Leu Leu  Pro Val Leu 
    1010                 1015                 1020             


Leu Ser  Phe Phe Gly Pro Tyr  Pro Glu Val Ser Pro  Ala Asn Gly 
    1025                 1030                 1035             


Leu Asn  Arg Leu Pro Thr Pro  Ser Pro Glu Pro Pro  Pro Ser Val 
    1040                 1045                 1050             


Val Arg  Phe Ala Met Pro Pro  Gly His Thr His Ser  Gly Ser Asp 
    1055                 1060                 1065             


Ser Ser  Asp Ser Glu Tyr Ser  Ser Gln Thr Thr Val  Ser Gly Leu 
    1070                 1075                 1080             


Ser Glu  Glu Leu Arg His Tyr  Glu Ala Gln Gln Gly  Ala Gly Gly 
    1085                 1090                 1095             


Pro Ala  His Gln Val Ile Val  Glu Ala Thr Glu Asn  Pro Val Phe 
    1100                 1105                 1110             


Ala His  Ser Thr Val Val His  Pro Glu Ser Arg His  His Pro Pro 
    1115                 1120                 1125             


Ser Asn  Pro Arg Gln Gln Pro  His Leu Asp Ser Gly  Ser Leu Pro 
    1130                 1135                 1140             


Pro Gly  Arg Gln Gly Gln Gln  Pro Arg Arg Asp Pro  Pro Arg Glu 
    1145                 1150                 1155             


Gly Leu  Trp Pro Pro Pro Tyr  Arg Pro Arg Arg Asp  Ala Phe Glu 
    1160                 1165                 1170             


Ile Ser  Thr Glu Gly His Ser  Gly Pro Ser Asn Arg  Ala Arg Trp 
    1175                 1180                 1185             


Gly Pro  Arg Gly Ala Arg Ser  His Asn Pro Arg Asn  Pro Ala Ser 
    1190                 1195                 1200             


Thr Ala  Met Gly Ser Ser Val  Pro Gly Tyr Cys Gln  Pro Ile Thr 
    1205                 1210                 1215             


Thr Val  Thr Ala Ser Ala Ser  Val Thr Val Ala Val  His Pro Pro 
    1220                 1225                 1230             


Pro Val  Pro Gly Pro Gly Arg  Asn Pro Arg Gly Gly  Leu Cys Pro 
    1235                 1240                 1245             


Gly Tyr  Pro Glu Thr Asp His  Gly Leu Phe Glu Asp  Pro His Val 
    1250                 1255                 1260             


Pro Phe  His Val Arg Cys Glu  Arg Arg Asp Ser Lys  Val Glu Val 
    1265                 1270                 1275             


Ile Glu  Leu Gln Asp Val Glu  Cys Glu Glu Arg Pro  Arg Gly Ser 
    1280                 1285                 1290             


Ser Ser  Asn 
    1295     


<210>  1076
<211>  1296
<212>  PRT
<213>  Homo sapiens

<400>  1076

Met Phe Asn Pro Gln Leu Met Ile Gln Thr Pro Lys Glu Glu Gly Ala 
1               5                   10                  15      


Asn Val Leu Thr Thr Glu Ala Leu Leu Gln His Leu Asp Ser Ala Leu 
            20                  25                  30          


Gln Ala Ser Arg Val His Val Tyr Met Tyr Asn Arg Gln Trp Lys Leu 
        35                  40                  45              


Glu His Leu Cys Tyr Lys Ser Gly Glu Leu Ile Thr Glu Thr Gly Tyr 
    50                  55                  60                  


Met Asp Gln Ile Ile Glu Tyr Leu Tyr Pro Cys Leu Ile Ile Thr Pro 
65                  70                  75                  80  


Leu Asp Cys Phe Trp Glu Gly Ala Lys Leu Gln Ser Gly Thr Ala Tyr 
                85                  90                  95      


Leu Leu Gly Lys Pro Pro Leu Arg Trp Thr Asn Phe Asp Pro Leu Glu 
            100                 105                 110         


Phe Leu Glu Glu Leu Lys Lys Ile Asn Tyr Gln Val Asp Ser Trp Glu 
        115                 120                 125             


Glu Met Leu Asn Lys Ala Glu Val Gly His Gly Tyr Met Asp Arg Pro 
    130                 135                 140                 


Cys Leu Asn Pro Ala Asp Pro Asp Cys Pro Ala Thr Ala Pro Asn Lys 
145                 150                 155                 160 


Asn Ser Thr Lys Pro Leu Asp Met Ala Leu Val Leu Asn Gly Gly Cys 
                165                 170                 175     


His Gly Leu Ser Arg Lys Tyr Met His Trp Gln Glu Glu Leu Ile Val 
            180                 185                 190         


Gly Gly Thr Val Lys Asn Ser Thr Gly Lys Leu Val Ser Ala His Ala 
        195                 200                 205             


Leu Gln Thr Met Phe Gln Leu Met Thr Pro Lys Gln Met Tyr Glu His 
    210                 215                 220                 


Phe Lys Gly Tyr Glu Tyr Val Ser His Ile Asn Trp Asn Glu Asp Lys 
225                 230                 235                 240 


Ala Ala Ala Ile Leu Glu Ala Trp Gln Arg Thr Tyr Val Glu Val Val 
                245                 250                 255     


His Gln Ser Val Ala Gln Asn Ser Thr Gln Lys Val Leu Ser Phe Thr 
            260                 265                 270         


Thr Thr Thr Leu Asp Asp Ile Leu Lys Ser Phe Ser Asp Val Ser Val 
        275                 280                 285             


Ile Arg Val Ala Ser Gly Tyr Leu Leu Met Leu Ala Tyr Ala Cys Leu 
    290                 295                 300                 


Thr Met Leu Arg Trp Asp Cys Ser Lys Ser Gln Gly Ala Val Gly Leu 
305                 310                 315                 320 


Ala Gly Val Leu Leu Val Ala Leu Ser Val Ala Ala Gly Leu Gly Leu 
                325                 330                 335     


Cys Ser Leu Ile Gly Ile Ser Phe Asn Ala Ala Thr Thr Gln Val Leu 
            340                 345                 350         


Pro Phe Leu Ala Leu Gly Val Gly Val Asp Asp Val Phe Leu Leu Ala 
        355                 360                 365             


His Ala Phe Ser Glu Thr Gly Gln Asn Lys Arg Ile Pro Phe Glu Asp 
    370                 375                 380                 


Arg Thr Gly Glu Cys Leu Lys Arg Thr Gly Ala Ser Val Ala Leu Thr 
385                 390                 395                 400 


Ser Ile Ser Asn Val Thr Ala Phe Phe Met Ala Ala Leu Ile Pro Ile 
                405                 410                 415     


Pro Ala Leu Arg Ala Phe Ser Leu Gln Ala Ala Val Val Val Val Phe 
            420                 425                 430         


Asn Phe Ala Met Val Leu Leu Ile Phe Pro Ala Ile Leu Ser Met Asp 
        435                 440                 445             


Leu Tyr Arg Arg Glu Asp Arg Arg Leu Asp Ile Phe Cys Cys Phe Thr 
    450                 455                 460                 


Ser Pro Cys Val Ser Arg Val Ile Gln Val Glu Pro Gln Ala Tyr Thr 
465                 470                 475                 480 


Asp Thr His Asp Asn Thr Arg Tyr Ser Pro Pro Pro Pro Tyr Ser Ser 
                485                 490                 495     


His Ser Phe Ala His Glu Thr Gln Ile Thr Met Gln Ser Thr Val Gln 
            500                 505                 510         


Leu Arg Thr Glu Tyr Asp Pro His Thr His Val Tyr Tyr Thr Thr Ala 
        515                 520                 525             


Glu Pro Arg Ser Glu Ile Ser Val Gln Pro Val Thr Val Thr Gln Asp 
    530                 535                 540                 


Thr Leu Ser Cys Gln Ser Pro Glu Ser Thr Ser Ser Thr Arg Asp Leu 
545                 550                 555                 560 


Leu Ser Gln Phe Ser Asp Ser Ser Leu His Cys Leu Glu Pro Pro Cys 
                565                 570                 575     


Thr Lys Trp Thr Leu Ser Ser Phe Ala Glu Lys His Tyr Ala Pro Phe 
            580                 585                 590         


Leu Leu Lys Pro Lys Ala Lys Val Val Val Ile Phe Leu Phe Leu Gly 
        595                 600                 605             


Leu Leu Gly Val Ser Leu Tyr Gly Thr Thr Arg Val Arg Asp Gly Leu 
    610                 615                 620                 


Asp Leu Thr Asp Ile Val Pro Arg Glu Thr Arg Glu Tyr Asp Phe Ile 
625                 630                 635                 640 


Ala Ala Gln Phe Lys Tyr Phe Ser Phe Tyr Asn Met Tyr Ile Val Thr 
                645                 650                 655     


Gln Lys Ala Asp Tyr Pro Asn Ile Gln His Leu Leu Tyr Asp Leu His 
            660                 665                 670         


Arg Ser Phe Ser Asn Val Lys Tyr Val Met Leu Glu Glu Asn Lys Gln 
        675                 680                 685             


Leu Pro Lys Met Trp Leu His Tyr Phe Arg Asp Trp Leu Gln Gly Leu 
    690                 695                 700                 


Gln Asp Ala Phe Asp Ser Asp Trp Glu Thr Gly Lys Ile Met Pro Asn 
705                 710                 715                 720 


Asn Tyr Lys Asn Gly Ser Asp Asp Gly Val Leu Ala Tyr Lys Leu Leu 
                725                 730                 735     


Val Gln Thr Gly Ser Arg Asp Lys Pro Ile Asp Ile Ser Gln Leu Thr 
            740                 745                 750         


Lys Gln Arg Leu Val Asp Ala Asp Gly Ile Ile Asn Pro Ser Ala Phe 
        755                 760                 765             


Tyr Ile Tyr Leu Thr Ala Trp Val Ser Asn Asp Pro Val Ala Tyr Ala 
    770                 775                 780                 


Ala Ser Gln Ala Asn Ile Arg Pro His Arg Pro Glu Trp Val His Asp 
785                 790                 795                 800 


Lys Ala Asp Tyr Met Pro Glu Thr Arg Leu Arg Ile Pro Ala Ala Glu 
                805                 810                 815     


Pro Ile Glu Tyr Ala Gln Phe Pro Phe Tyr Leu Asn Gly Leu Arg Asp 
            820                 825                 830         


Thr Ser Asp Phe Val Glu Ala Ile Glu Lys Val Arg Thr Ile Cys Ser 
        835                 840                 845             


Asn Tyr Thr Ser Leu Gly Leu Ser Ser Tyr Pro Asn Gly Tyr Pro Phe 
    850                 855                 860                 


Leu Phe Trp Glu Gln Tyr Ile Gly Leu Arg His Trp Leu Leu Leu Phe 
865                 870                 875                 880 


Ile Ser Val Val Leu Ala Cys Thr Phe Leu Val Cys Ala Val Phe Leu 
                885                 890                 895     


Leu Asn Pro Trp Thr Ala Gly Ile Ile Val Met Val Leu Ala Leu Met 
            900                 905                 910         


Thr Val Glu Leu Phe Gly Met Met Gly Leu Ile Gly Ile Lys Leu Ser 
        915                 920                 925             


Ala Val Pro Val Val Ile Leu Ile Ala Ser Val Gly Ile Gly Val Glu 
    930                 935                 940                 


Phe Thr Val His Val Ala Leu Ala Phe Leu Thr Ala Ile Gly Asp Lys 
945                 950                 955                 960 


Asn Arg Arg Ala Val Leu Ala Leu Glu His Met Phe Ala Pro Val Leu 
                965                 970                 975     


Asp Gly Ala Val Ser Thr Leu Leu Gly Val Leu Met Leu Ala Gly Ser 
            980                 985                 990         


Glu Phe Asp Phe Ile Val Arg Tyr  Phe Phe Ala Val Leu  Ala Ile Leu 
        995                 1000                 1005             


Thr Ile  Leu Gly Val Leu Asn  Gly Leu Val Leu Leu  Pro Val Leu 
    1010                 1015                 1020             


Leu Ser  Phe Phe Gly Pro Tyr  Pro Glu Val Ser Pro  Ala Asn Gly 
    1025                 1030                 1035             


Leu Asn  Arg Leu Pro Thr Pro  Ser Pro Glu Pro Pro  Pro Ser Val 
    1040                 1045                 1050             


Val Arg  Phe Ala Met Pro Pro  Gly His Thr His Ser  Gly Ser Asp 
    1055                 1060                 1065             


Ser Ser  Asp Ser Glu Tyr Ser  Ser Gln Thr Thr Val  Ser Gly Leu 
    1070                 1075                 1080             


Ser Glu  Glu Leu Arg His Tyr  Glu Ala Gln Gln Gly  Ala Gly Gly 
    1085                 1090                 1095             


Pro Ala  His Gln Val Ile Val  Glu Ala Thr Glu Asn  Pro Val Phe 
    1100                 1105                 1110             


Ala His  Ser Thr Val Val His  Pro Glu Ser Arg His  His Pro Pro 
    1115                 1120                 1125             


Ser Asn  Pro Arg Gln Gln Pro  His Leu Asp Ser Gly  Ser Leu Pro 
    1130                 1135                 1140             


Pro Gly  Arg Gln Gly Gln Gln  Pro Arg Arg Asp Pro  Pro Arg Glu 
    1145                 1150                 1155             


Gly Leu  Trp Pro Pro Pro Tyr  Arg Pro Arg Arg Asp  Ala Phe Glu 
    1160                 1165                 1170             


Ile Ser  Thr Glu Gly His Ser  Gly Pro Ser Asn Arg  Ala Arg Trp 
    1175                 1180                 1185             


Gly Pro  Arg Gly Ala Arg Ser  His Asn Pro Arg Asn  Pro Ala Ser 
    1190                 1195                 1200             


Thr Ala  Met Gly Ser Ser Val  Pro Gly Tyr Cys Gln  Pro Ile Thr 
    1205                 1210                 1215             


Thr Val  Thr Ala Ser Ala Ser  Val Thr Val Ala Val  His Pro Pro 
    1220                 1225                 1230             


Pro Val  Pro Gly Pro Gly Arg  Asn Pro Arg Gly Gly  Leu Cys Pro 
    1235                 1240                 1245             


Gly Tyr  Pro Glu Thr Asp His  Gly Leu Phe Glu Asp  Pro His Val 
    1250                 1255                 1260             


Pro Phe  His Val Arg Cys Glu  Arg Arg Asp Ser Lys  Val Glu Val 
    1265                 1270                 1275             


Ile Glu  Leu Gln Asp Val Glu  Cys Glu Glu Arg Pro  Arg Gly Ser 
    1280                 1285                 1290             


Ser Ser  Asn 
    1295     


<210>  1077
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  1077

Met Gly Asn Cys Gln Ala Gly His Asn Leu His Leu Cys Leu Ala His 
1               5                   10                  15      


His Pro Pro Leu Val Cys Ala Thr Leu Ile Leu Leu Leu Leu Gly Leu 
            20                  25                  30          


Ser Gly Leu Gly Leu Gly Ser Phe Leu Leu Thr His Arg Thr Gly Leu 
        35                  40                  45              


Arg Ser Pro Asp Ile Pro Gln Asp Trp Val Ser Phe Leu Arg Ser Phe 
    50                  55                  60                  


Gly Gln Leu Thr Leu Cys Pro Arg Asn Gly Thr Val Thr Gly Lys Trp 
65                  70                  75                  80  


Arg Gly Ser His Val Val Gly Leu Leu Thr Thr Leu Asn Phe Gly Asp 
                85                  90                  95      


Gly Pro Asp Arg Asn Lys Thr Arg Thr Phe Gln Ala Thr Val Leu Gly 
            100                 105                 110         


Ser Gln Met Gly Leu Lys Gly Ser Ser Ala Gly Gln Leu Val Leu Ile 
        115                 120                 125             


Thr Ala Arg Val Thr Thr Glu Arg Thr Ala Gly Thr Cys Leu Tyr Phe 
    130                 135                 140                 


Ser Ala Val Pro Gly Ile Leu Pro Ser Ser Gln Pro Pro Ile Ser Cys 
145                 150                 155                 160 


Ser Glu Glu Gly Ala Gly Asn Ala Thr Leu Ser Pro Arg Met Gly Glu 
                165                 170                 175     


Glu Cys Val Ser Val Trp Ser His Glu Gly Leu Val Leu Thr Lys Leu 
            180                 185                 190         


Leu Thr Ser Glu Glu Leu Ala Leu Cys Gly Ser Arg Leu Leu Val Leu 
        195                 200                 205             


Gly Ser Phe Leu Leu Leu Phe Cys Gly Leu Leu Cys Cys Val Thr Ala 
    210                 215                 220                 


Met Cys Phe His Pro Arg Arg Glu Ser His Trp Ser Arg Thr Arg Leu 
225                 230                 235                 240 


<210>  1078
<211>  883
<212>  PRT
<213>  Homo sapiens

<400>  1078

Met Gln Lys Ile Met His Ile Ser Val Leu Leu Ser Pro Val Leu Trp 
1               5                   10                  15      


Gly Leu Ile Phe Gly Val Ser Ser Asn Ser Ile Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Pro Arg Gly Ala Asp Gln Glu Tyr Ser Ala Phe Arg Val Gly Met 
        35                  40                  45              


Val Gln Phe Ser Thr Ser Glu Phe Arg Leu Thr Pro His Ile Asp Asn 
    50                  55                  60                  


Leu Glu Val Ala Asn Ser Phe Ala Val Thr Asn Ala Phe Cys Ser Gln 
65                  70                  75                  80  


Phe Ser Arg Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Lys Lys Ser 
                85                  90                  95      


Val Asn Thr Ile Thr Ser Phe Cys Gly Thr Leu His Val Ser Phe Ile 
            100                 105                 110         


Thr Pro Ser Phe Pro Thr Asp Gly Thr His Pro Phe Val Ile Gln Met 
        115                 120                 125             


Arg Pro Asp Leu Lys Gly Ala Leu Leu Ser Leu Ile Glu Tyr Tyr Gln 
    130                 135                 140                 


Trp Asp Lys Phe Ala Tyr Leu Tyr Asp Ser Asp Arg Gly Leu Ser Thr 
145                 150                 155                 160 


Leu Gln Ala Val Leu Asp Ser Ala Ala Glu Lys Lys Trp Gln Val Thr 
                165                 170                 175     


Ala Ile Asn Val Gly Asn Ile Asn Asn Asp Lys Lys Asp Glu Met Tyr 
            180                 185                 190         


Arg Ser Leu Phe Gln Asp Leu Glu Leu Lys Lys Glu Arg Arg Val Ile 
        195                 200                 205             


Leu Asp Cys Glu Arg Asp Lys Val Asn Asp Ile Val Asp Gln Val Ile 
    210                 215                 220                 


Thr Ile Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala Asn Leu 
225                 230                 235                 240 


Gly Phe Thr Asp Gly Asp Leu Leu Lys Ile Gln Phe Gly Gly Ala Asn 
                245                 250                 255     


Val Ser Gly Phe Gln Ile Val Asp Tyr Asp Asp Ser Leu Val Ser Lys 
            260                 265                 270         


Phe Ile Glu Arg Trp Ser Thr Leu Glu Glu Lys Glu Tyr Pro Gly Ala 
        275                 280                 285             


His Thr Thr Thr Ile Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Ala Val 
    290                 295                 300                 


Gln Val Met Thr Glu Ala Phe Arg Asn Leu Arg Lys Gln Arg Ile Glu 
305                 310                 315                 320 


Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala Val 
                325                 330                 335     


Pro Trp Gly Gln Gly Val Glu Ile Glu Arg Ala Leu Lys Gln Val Gln 
            340                 345                 350         


Val Glu Gly Leu Ser Gly Asn Ile Lys Phe Asp Gln Asn Gly Lys Arg 
        355                 360                 365             


Ile Asn Tyr Thr Ile Asn Ile Met Glu Leu Lys Thr Asn Gly Pro Arg 
    370                 375                 380                 


Lys Ile Gly Tyr Trp Ser Glu Val Asp Lys Met Val Val Thr Leu Thr 
385                 390                 395                 400 


Glu Leu Pro Ser Gly Asn Asp Thr Ser Gly Leu Glu Asn Lys Thr Val 
                405                 410                 415     


Val Val Thr Thr Ile Leu Glu Ser Pro Tyr Val Met Met Lys Lys Asn 
            420                 425                 430         


His Glu Met Leu Glu Gly Asn Glu Arg Tyr Glu Gly Tyr Cys Val Asp 
        435                 440                 445             


Leu Ala Ala Glu Ile Ala Lys His Cys Gly Phe Lys Tyr Lys Leu Thr 
    450                 455                 460                 


Ile Val Gly Asp Gly Lys Tyr Gly Ala Arg Asp Ala Asp Thr Lys Ile 
465                 470                 475                 480 


Trp Asn Gly Met Val Gly Glu Leu Val Tyr Gly Lys Ala Asp Ile Ala 
                485                 490                 495     


Ile Ala Pro Leu Thr Ile Thr Leu Val Arg Glu Glu Val Ile Asp Phe 
            500                 505                 510         


Ser Lys Pro Phe Met Ser Leu Gly Ile Ser Ile Met Ile Lys Lys Pro 
        515                 520                 525             


Gln Lys Ser Lys Pro Gly Val Phe Ser Phe Leu Asp Pro Leu Ala Tyr 
    530                 535                 540                 


Glu Ile Trp Met Cys Ile Val Phe Ala Tyr Ile Gly Val Ser Val Val 
545                 550                 555                 560 


Leu Phe Leu Val Ser Arg Phe Ser Pro Tyr Glu Trp His Thr Glu Glu 
                565                 570                 575     


Phe Glu Asp Gly Arg Glu Thr Gln Ser Ser Glu Ser Thr Asn Glu Phe 
            580                 585                 590         


Gly Ile Phe Asn Ser Leu Trp Phe Ser Leu Gly Ala Phe Met Arg Gln 
        595                 600                 605             


Gly Cys Asp Ile Ser Pro Arg Ser Leu Ser Gly Arg Ile Val Gly Gly 
    610                 615                 620                 


Val Trp Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn 
625                 630                 635                 640 


Leu Ala Ala Phe Leu Thr Val Glu Arg Met Val Ser Pro Ile Glu Ser 
                645                 650                 655     


Ala Glu Asp Leu Ser Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu Asp 
            660                 665                 670         


Ser Gly Ser Thr Lys Glu Phe Phe Arg Arg Ser Lys Ile Ala Val Phe 
        675                 680                 685             


Asp Lys Met Trp Thr Tyr Met Arg Ser Ala Glu Pro Ser Val Phe Val 
    690                 695                 700                 


Arg Thr Thr Ala Glu Gly Val Ala Arg Val Arg Lys Ser Lys Gly Lys 
705                 710                 715                 720 


Tyr Ala Tyr Leu Leu Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln Arg 
                725                 730                 735     


Lys Pro Cys Asp Thr Met Lys Val Gly Gly Asn Leu Asp Ser Lys Gly 
            740                 745                 750         


Tyr Gly Ile Ala Thr Pro Lys Gly Ser Ser Leu Arg Asn Ala Val Asn 
        755                 760                 765             


Leu Ala Val Leu Lys Leu Asn Glu Gln Gly Leu Leu Asp Lys Leu Lys 
    770                 775                 780                 


Asn Lys Trp Trp Tyr Asp Lys Gly Glu Cys Gly Ser Gly Gly Gly Asp 
785                 790                 795                 800 


Ser Lys Glu Lys Thr Ser Ala Leu Ser Leu Ser Asn Val Ala Gly Val 
                805                 810                 815     


Phe Tyr Ile Leu Val Gly Gly Leu Gly Leu Ala Met Leu Val Ala Leu 
            820                 825                 830         


Ile Glu Phe Cys Tyr Lys Ser Arg Ala Glu Ala Lys Arg Met Lys Val 
        835                 840                 845             


Ala Lys Asn Ala Gln Asn Ile Asn Pro Ser Ser Ser Gln Asn Ser Gln 
    850                 855                 860                 


Asn Phe Ala Thr Tyr Lys Glu Gly Tyr Asn Val Tyr Gly Ile Glu Ser 
865                 870                 875                 880 


Val Lys Ile 
            


<210>  1079
<211>  836
<212>  PRT
<213>  Homo sapiens

<400>  1079

Met Val Gln Phe Ser Thr Ser Glu Phe Arg Leu Thr Pro His Ile Asp 
1               5                   10                  15      


Asn Leu Glu Val Ala Asn Ser Phe Ala Val Thr Asn Ala Phe Cys Ser 
            20                  25                  30          


Gln Phe Ser Arg Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Lys Lys 
        35                  40                  45              


Ser Val Asn Thr Ile Thr Ser Phe Cys Gly Thr Leu His Val Ser Phe 
    50                  55                  60                  


Ile Thr Pro Ser Phe Pro Thr Asp Gly Thr His Pro Phe Val Ile Gln 
65                  70                  75                  80  


Met Arg Pro Asp Leu Lys Gly Ala Leu Leu Ser Leu Ile Glu Tyr Tyr 
                85                  90                  95      


Gln Trp Asp Lys Phe Ala Tyr Leu Tyr Asp Ser Asp Arg Gly Leu Ser 
            100                 105                 110         


Thr Leu Gln Ala Val Leu Asp Ser Ala Ala Glu Lys Lys Trp Gln Val 
        115                 120                 125             


Thr Ala Ile Asn Val Gly Asn Ile Asn Asn Asp Lys Lys Asp Glu Met 
    130                 135                 140                 


Tyr Arg Ser Leu Phe Gln Asp Leu Glu Leu Lys Lys Glu Arg Arg Val 
145                 150                 155                 160 


Ile Leu Asp Cys Glu Arg Asp Lys Val Asn Asp Ile Val Asp Gln Val 
                165                 170                 175     


Ile Thr Ile Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala Asn 
            180                 185                 190         


Leu Gly Phe Thr Asp Gly Asp Leu Leu Lys Ile Gln Phe Gly Gly Ala 
        195                 200                 205             


Asn Val Ser Gly Phe Gln Ile Val Asp Tyr Asp Asp Ser Leu Val Ser 
    210                 215                 220                 


Lys Phe Ile Glu Arg Trp Ser Thr Leu Glu Glu Lys Glu Tyr Pro Gly 
225                 230                 235                 240 


Ala His Thr Thr Thr Ile Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Ala 
                245                 250                 255     


Val Gln Val Met Thr Glu Ala Phe Arg Asn Leu Arg Lys Gln Arg Ile 
            260                 265                 270         


Glu Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala 
        275                 280                 285             


Val Pro Trp Gly Gln Gly Val Glu Ile Glu Arg Ala Leu Lys Gln Val 
    290                 295                 300                 


Gln Val Glu Gly Leu Ser Gly Asn Ile Lys Phe Asp Gln Asn Gly Lys 
305                 310                 315                 320 


Arg Ile Asn Tyr Thr Ile Asn Ile Met Glu Leu Lys Thr Asn Gly Pro 
                325                 330                 335     


Arg Lys Ile Gly Tyr Trp Ser Glu Val Asp Lys Met Val Val Thr Leu 
            340                 345                 350         


Thr Glu Leu Pro Ser Gly Asn Asp Thr Ser Gly Leu Glu Asn Lys Thr 
        355                 360                 365             


Val Val Val Thr Thr Ile Leu Glu Ser Pro Tyr Val Met Met Lys Lys 
    370                 375                 380                 


Asn His Glu Met Leu Glu Gly Asn Glu Arg Tyr Glu Gly Tyr Cys Val 
385                 390                 395                 400 


Asp Leu Ala Ala Glu Ile Ala Lys His Cys Gly Phe Lys Tyr Lys Leu 
                405                 410                 415     


Thr Ile Val Gly Asp Gly Lys Tyr Gly Ala Arg Asp Ala Asp Thr Lys 
            420                 425                 430         


Ile Trp Asn Gly Met Val Gly Glu Leu Val Tyr Gly Lys Ala Asp Ile 
        435                 440                 445             


Ala Ile Ala Pro Leu Thr Ile Thr Leu Val Arg Glu Glu Val Ile Asp 
    450                 455                 460                 


Phe Ser Lys Pro Phe Met Ser Leu Gly Ile Ser Ile Met Ile Lys Lys 
465                 470                 475                 480 


Pro Gln Lys Ser Lys Pro Gly Val Phe Ser Phe Leu Asp Pro Leu Ala 
                485                 490                 495     


Tyr Glu Ile Trp Met Cys Ile Val Phe Ala Tyr Ile Gly Val Ser Val 
            500                 505                 510         


Val Leu Phe Leu Val Ser Arg Phe Ser Pro Tyr Glu Trp His Thr Glu 
        515                 520                 525             


Glu Phe Glu Asp Gly Arg Glu Thr Gln Ser Ser Glu Ser Thr Asn Glu 
    530                 535                 540                 


Phe Gly Ile Phe Asn Ser Leu Trp Phe Ser Leu Gly Ala Phe Met Arg 
545                 550                 555                 560 


Gln Gly Cys Asp Ile Ser Pro Arg Ser Leu Ser Gly Arg Ile Val Gly 
                565                 570                 575     


Gly Val Trp Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala 
            580                 585                 590         


Asn Leu Ala Ala Phe Leu Thr Val Glu Arg Met Val Ser Pro Ile Glu 
        595                 600                 605             


Ser Ala Glu Asp Leu Ser Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu 
    610                 615                 620                 


Asp Ser Gly Ser Thr Lys Glu Phe Phe Arg Arg Ser Lys Ile Ala Val 
625                 630                 635                 640 


Phe Asp Lys Met Trp Thr Tyr Met Arg Ser Ala Glu Pro Ser Val Phe 
                645                 650                 655     


Val Arg Thr Thr Ala Glu Gly Val Ala Arg Val Arg Lys Ser Lys Gly 
            660                 665                 670         


Lys Tyr Ala Tyr Leu Leu Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln 
        675                 680                 685             


Arg Lys Pro Cys Asp Thr Met Lys Val Gly Gly Asn Leu Asp Ser Lys 
    690                 695                 700                 


Gly Tyr Gly Ile Ala Thr Pro Lys Gly Ser Ser Leu Arg Thr Pro Val 
705                 710                 715                 720 


Asn Leu Ala Val Leu Lys Leu Ser Glu Gln Gly Val Leu Asp Lys Leu 
                725                 730                 735     


Lys Asn Lys Trp Trp Tyr Asp Lys Gly Glu Cys Gly Ala Lys Asp Ser 
            740                 745                 750         


Gly Ser Lys Glu Lys Thr Ser Ala Leu Ser Leu Ser Asn Val Ala Gly 
        755                 760                 765             


Val Phe Tyr Ile Leu Val Gly Gly Leu Gly Leu Ala Met Leu Val Ala 
    770                 775                 780                 


Leu Ile Glu Phe Cys Tyr Lys Ser Arg Ala Glu Ala Lys Arg Met Lys 
785                 790                 795                 800 


Val Ala Lys Asn Ala Gln Asn Ile Asn Pro Ser Ser Ser Gln Asn Ser 
                805                 810                 815     


Gln Asn Phe Ala Thr Tyr Lys Glu Gly Tyr Asn Val Tyr Gly Ile Glu 
            820                 825                 830         


Ser Val Lys Ile 
        835     


<210>  1080
<211>  620
<212>  PRT
<213>  Homo sapiens

<400>  1080

Met Ser Pro Ser Pro Thr Ala Leu Phe Cys Leu Gly Leu Cys Leu Gly 
1               5                   10                  15      


Arg Val Pro Ala Gln Ser Gly Pro Leu Pro Lys Pro Ser Leu Gln Ala 
            20                  25                  30          


Leu Pro Ser Ser Leu Val Pro Leu Glu Lys Pro Val Thr Leu Arg Cys 
        35                  40                  45              


Gln Gly Pro Pro Gly Val Asp Leu Tyr Arg Leu Glu Lys Leu Ser Ser 
    50                  55                  60                  


Ser Arg Tyr Gln Asp Gln Ala Val Leu Phe Ile Pro Ala Met Lys Arg 
65                  70                  75                  80  


Ser Leu Ala Gly Arg Tyr Arg Cys Ser Tyr Gln Asn Gly Ser Leu Trp 
                85                  90                  95      


Ser Leu Pro Ser Asp Gln Leu Glu Leu Val Ala Thr Gly Val Phe Ala 
            100                 105                 110         


Lys Pro Ser Leu Ser Ala Gln Pro Gly Pro Ala Val Ser Ser Gly Gly 
        115                 120                 125             


Asp Val Thr Leu Gln Cys Gln Thr Arg Tyr Gly Phe Asp Gln Phe Ala 
    130                 135                 140                 


Leu Tyr Lys Glu Gly Asp Pro Ala Pro Tyr Lys Asn Pro Glu Arg Trp 
145                 150                 155                 160 


Tyr Arg Ala Ser Phe Pro Ile Ile Thr Val Thr Ala Ala His Ser Gly 
                165                 170                 175     


Thr Tyr Arg Cys Tyr Ser Phe Ser Ser Arg Asp Pro Tyr Leu Trp Ser 
            180                 185                 190         


Ala Pro Ser Asp Pro Leu Glu Leu Val Val Thr Gly Thr Ser Val Thr 
        195                 200                 205             


Pro Ser Arg Leu Pro Thr Glu Pro Pro Ser Pro Val Ala Glu Phe Ser 
    210                 215                 220                 


Glu Ala Thr Ala Glu Leu Thr Val Ser Phe Thr Asn Glu Val Phe Thr 
225                 230                 235                 240 


Thr Glu Thr Ser Arg Ser Ile Thr Ala Ser Pro Lys Glu Ser Asp Ser 
                245                 250                 255     


Pro Ala Gly Glu Ser Cys Pro Pro Val Leu His Gln Gly Gln Pro Gly 
            260                 265                 270         


Pro Asp Met Pro Arg Gly Cys Asp Pro Asn Asn Pro Gly Gly Val Ser 
        275                 280                 285             


Gly Arg Gly Leu Ala Gln Pro Glu Glu Ala Pro Ala Ala Gln Gly Gln 
    290                 295                 300                 


Gly Cys Ala Glu Ala Ala Ser Ala Pro Pro Ala Pro Pro Ala Asp Pro 
305                 310                 315                 320 


Glu Ile Lys Arg Gly Ser Gly Trp Arg Pro Thr Gly Cys Ser Gln Pro 
                325                 330                 335     


Arg Val Met Phe Met Thr Ala Glu Pro Gln Ala Arg Ser Tyr Pro Arg 
            340                 345                 350         


Glu Gly Ser Trp His Gly Arg Arg Leu Lys Asp Trp Arg Val Trp Ser 
        355                 360                 365             


Val Glu Ala Gly Gly Gln Arg Leu Gln Leu Trp Lys Arg Gly His Ala 
    370                 375                 380                 


Ala Ser Ser Trp Cys Ser Ile Arg Glu Pro Phe Gly Gln Cys Leu Ser 
385                 390                 395                 400 


Val Cys Leu Pro Leu Cys Leu Arg Ala Pro Ser Ile Trp Asp Gly Arg 
                405                 410                 415     


Asn Leu Trp Arg Pro His Pro Pro Pro Cys Thr Leu Trp Met Thr Trp 
            420                 425                 430         


Tyr Pro Gly Trp Thr Thr Tyr Trp Pro Leu Ser Ser Thr Ser Leu Ile 
        435                 440                 445             


Trp Ala Pro Asp Gly Ser Leu Arg Phe Pro Ala Leu Arg Val Asp Ser 
    450                 455                 460                 


Val Pro Ser Ser Val Gln Asn Pro Pro Val Leu Pro Phe Gly Pro Leu 
465                 470                 475                 480 


Cys Ser Cys Leu Val Phe Pro Arg Asn Ser His Pro His Ser Ile Ser 
                485                 490                 495     


His Cys Gly Leu Thr Asn Leu Leu Ser Ser Leu Arg Thr Gly Leu Ala 
            500                 505                 510         


Gly Ser Leu Gly Met Ser Phe Ile Phe Leu Ser Val Lys Leu Ala Arg 
        515                 520                 525             


Cys Pro Leu Pro Phe Thr Leu Glu Asn Lys Ile Ser Leu Cys Asn Met 
    530                 535                 540                 


Val Lys Pro His Leu Tyr Gln Gln Asn Lys Lys Thr Gln Lys Leu Ala 
545                 550                 555                 560 


Arg Cys Gly Gly Ala Ser Leu Tyr Ser Gln Gln Leu Arg Gly Leu Arg 
                565                 570                 575     


Trp Glu Asn Gly Leu Ser Leu Gly Gly Arg Gly Cys Ser Glu Leu Arg 
            580                 585                 590         


Ser His His Cys Thr Leu Ala Arg Val Thr Lys Pro Asp Phe Val Ser 
        595                 600                 605             


Lys Asn Thr Gly Met Asn Met Ser Ile Thr Leu Ile 
    610                 615                 620 


<210>  1081
<211>  560
<212>  PRT
<213>  Homo sapiens

<400>  1081

Met Asp Leu Lys Thr Val Leu Ser Leu Pro Arg Tyr Pro Gly Glu Phe 
1               5                   10                  15      


Leu His Pro Val Val Tyr Ala Cys Thr Ala Val Met Leu Leu Cys Leu 
            20                  25                  30          


Leu Ala Ser Phe Val Thr Tyr Ile Val His Gln Ser Ala Ile Arg Ile 
        35                  40                  45              


Ser Arg Lys Gly Arg His Thr Leu Leu Asn Phe Cys Phe His Ala Ala 
    50                  55                  60                  


Leu Thr Phe Thr Val Phe Ala Gly Gly Ile Asn Arg Thr Lys Tyr Pro 
65                  70                  75                  80  


Ile Leu Cys Gln Ala Val Gly Ile Val Leu His Tyr Ser Thr Leu Ser 
                85                  90                  95      


Thr Met Leu Trp Ile Gly Val Thr Ala Arg Asn Ile Tyr Lys Gln Val 
            100                 105                 110         


Thr Lys Lys Ala Pro Leu Cys Leu Asp Thr Asp Gln Pro Pro Tyr Pro 
        115                 120                 125             


Arg Gln Pro Leu Leu Arg Phe Tyr Leu Val Ser Gly Gly Val Pro Phe 
    130                 135                 140                 


Ile Ile Cys Gly Val Thr Ala Ala Thr Asn Ile Arg Asn Tyr Gly Thr 
145                 150                 155                 160 


Glu Asp Glu Asp Thr Ala Tyr Cys Trp Met Ala Trp Glu Pro Ser Leu 
                165                 170                 175     


Gly Ala Phe Tyr Gly Pro Ala Ala Ile Ile Thr Leu Val Thr Cys Val 
            180                 185                 190         


Tyr Phe Leu Gly Thr Tyr Val Gln Leu Arg Arg His Pro Gly Arg Arg 
        195                 200                 205             


Tyr Glu Leu Arg Thr Gln Pro Glu Glu Gln Arg Arg Leu Ala Thr Pro 
    210                 215                 220                 


Glu Gly Gly Arg Gly Ile Arg Pro Gly Thr Pro Pro Ala His Asp Ala 
225                 230                 235                 240 


Pro Gly Ala Ser Val Leu Gln Asn Glu His Ser Phe Gln Ala Gln Leu 
                245                 250                 255     


Arg Ala Ala Ala Phe Thr Leu Phe Leu Phe Thr Ala Thr Trp Ala Phe 
            260                 265                 270         


Gly Ala Leu Ala Val Ser Gln Gly His Phe Leu Asp Met Val Phe Ser 
        275                 280                 285             


Cys Leu Tyr Gly Ala Phe Cys Val Thr Leu Gly Leu Phe Val Leu Ile 
    290                 295                 300                 


His His Cys Ala Lys Arg Glu Asp Val Trp Gln Cys Trp Trp Ala Cys 
305                 310                 315                 320 


Cys Pro Pro Arg Lys Asp Ala His Pro Ala Leu Asp Ala Asn Gly Ala 
                325                 330                 335     


Ala Leu Gly Arg Ala Ala Cys Leu His Ser Pro Gly Leu Gly Gln Pro 
            340                 345                 350         


Arg Gly Phe Ala His Pro Pro Gly Pro Cys Lys Met Thr Asn Leu Gln 
        355                 360                 365             


Ala Ala Gln Gly His Ala Ser Cys Leu Ser Pro Ala Thr Pro Cys Cys 
    370                 375                 380                 


Ala Lys Met His Cys Glu Pro Leu Thr Ala Asp Glu Ala His Val His 
385                 390                 395                 400 


Leu Gln Glu Glu Gly Ala Phe Gly His Asp Pro His Leu His Gly Cys 
                405                 410                 415     


Leu Gln Gly Arg Thr Lys Pro Pro Tyr Phe Ser Arg His Pro Ala Glu 
            420                 425                 430         


Glu Pro Glu Tyr Ala Tyr His Ile Pro Ser Ser Leu Asp Gly Ser Pro 
        435                 440                 445             


Arg Ser Ser Arg Thr Asp Ser Pro Pro Ser Ser Leu Asp Gly Pro Ala 
    450                 455                 460                 


Gly Thr His Thr Leu Ala Cys Cys Thr Gln Gly Asp Pro Phe Pro Met 
465                 470                 475                 480 


Val Thr Gln Pro Glu Gly Ser Asp Gly Ser Pro Ala Leu Tyr Ser Cys 
                485                 490                 495     


Pro Thr Gln Pro Gly Arg Glu Ala Ala Leu Gly Pro Gly His Leu Glu 
            500                 505                 510         


Met Leu Arg Arg Thr Gln Ser Leu Pro Phe Gly Gly Pro Ser Gln Asn 
        515                 520                 525             


Gly Leu Pro Lys Gly Lys Leu Leu Glu Gly Leu Pro Phe Gly Thr Asp 
    530                 535                 540                 


Gly Thr Gly Asn Ile Arg Thr Gly Pro Trp Lys Asn Glu Thr Thr Val 
545                 550                 555                 560 


<210>  1082
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  1082

Met Pro Val Pro Ala Ser Trp Pro His Leu Pro Ser Pro Phe Leu Leu 
1               5                   10                  15      


Met Thr Leu Leu Leu Gly Arg Leu Thr Gly Val Ala Gly Glu Asp Glu 
            20                  25                  30          


Leu Gln Val Ile Gln Pro Glu Lys Ser Val Ser Val Ala Ala Gly Glu 
        35                  40                  45              


Ser Ala Thr Leu Arg Cys Ala Met Thr Ser Leu Ile Pro Val Gly Pro 
    50                  55                  60                  


Ile Met Trp Phe Arg Gly Ala Gly Ala Gly Arg Glu Leu Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Glu Leu Thr 
                85                  90                  95      


Lys Arg Asn Asn Leu Asp Phe Ser Ile Ser Ile Ser Asn Ile Thr Pro 
            100                 105                 110         


Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser Pro 
        115                 120                 125             


Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val Arg 
    130                 135                 140                 


Glu Ala Ala Leu Ala Pro Thr Ala Pro Leu Leu Val Ala Leu Leu Leu 
145                 150                 155                 160 


Gly Pro Lys Leu Leu Leu Val Val Gly Val Ser Ala Ile Tyr Ile Cys 
                165                 170                 175     


Trp Lys Gln Lys Ala 
            180     


<210>  1083
<211>  363
<212>  PRT
<213>  Homo sapiens

<400>  1083

Met Glu Arg Arg Arg Leu Leu Gly Gly Met Ala Leu Leu Leu Leu Gln 
1               5                   10                  15      


Ala Leu Pro Ser Pro Leu Ser Ala Arg Ala Glu Pro Pro Gln Asp Lys 
            20                  25                  30          


Glu Ala Cys Val Gly Thr Asn Asn Gln Ser Tyr Ile Cys Asp Thr Gly 
        35                  40                  45              


His Cys Cys Gly Gln Ser Gln Cys Cys Asn Tyr Tyr Tyr Glu Leu Trp 
    50                  55                  60                  


Trp Phe Trp Leu Val Trp Thr Ile Ile Ile Ile Leu Ser Cys Cys Cys 
65                  70                  75                  80  


Val Cys His His Arg Arg Ala Lys His Arg Leu Gln Ala Gln Gln Arg 
                85                  90                  95      


Gln His Glu Ile Asn Leu Ile Ala Tyr Arg Glu Ala His Asn Tyr Ser 
            100                 105                 110         


Ala Leu Pro Phe Tyr Phe Arg Phe Leu Pro Asn Tyr Leu Leu Pro Pro 
        115                 120                 125             


Tyr Glu Glu Val Val Asn Arg Pro Pro Thr Pro Pro Pro Pro Tyr Ser 
    130                 135                 140                 


Ala Phe Gln Leu Gln Gln Gln Gln Leu Leu Pro Pro Gln Cys Gly Pro 
145                 150                 155                 160 


Ala Gly Gly Ser Pro Pro Gly Ile Asp Pro Thr Arg Gly Ser Gln Gly 
                165                 170                 175     


Ala Gln Ser Ser Pro Leu Ser Glu Pro Ser Arg Ser Ser Thr Arg Pro 
            180                 185                 190         


Pro Ser Ile Ala Asp Pro Asp Pro Ser Asp Leu Pro Val Asp Arg Ala 
        195                 200                 205             


Ala Thr Lys Ala Pro Gly Met Glu Pro Ser Gly Ser Val Ala Gly Leu 
    210                 215                 220                 


Gly Glu Leu Asp Pro Gly Ala Phe Leu Asp Lys Asp Ala Glu Cys Arg 
225                 230                 235                 240 


Glu Glu Leu Leu Lys Asp Asp Ser Ser Glu His Gly Ala Pro Asp Ser 
                245                 250                 255     


Lys Glu Lys Thr Pro Gly Arg His Arg Arg Phe Thr Gly Asp Ser Gly 
            260                 265                 270         


Ile Glu Val Cys Val Cys Asn Arg Gly His His Asp Asp Asp Leu Lys 
        275                 280                 285             


Glu Phe Asn Thr Leu Ile Asp Asp Ala Leu Asp Gly Pro Leu Asp Phe 
    290                 295                 300                 


Cys Asp Ser Cys His Val Arg Pro Pro Gly Asp Glu Glu Glu Gly Leu 
305                 310                 315                 320 


Cys Gln Ser Ser Glu Glu Gln Ala Arg Glu Pro Gly His Pro His Leu 
                325                 330                 335     


Pro Arg Pro Pro Ala Cys Leu Leu Leu Asn Thr Ile Asn Glu Gln Asp 
            340                 345                 350         


Ser Pro Asn Ser Gln Ser Ser Ser Ser Pro Ser 
        355                 360             


<210>  1084
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  1084

Met Leu Gln Asp Pro Asp Ser Asp Gln Pro Leu Asn Ser Leu Asp Val 
1               5                   10                  15      


Lys Pro Leu Arg Lys Pro Arg Ile Pro Met Glu Thr Phe Arg Lys Val 
            20                  25                  30          


Gly Ile Pro Ile Ile Ile Ala Leu Leu Ser Leu Ala Ser Ile Ile Ile 
        35                  40                  45              


Val Val Val Leu Ile Lys Val Ile Leu Asp Lys Tyr Tyr Phe Leu Cys 
    50                  55                  60                  


Gly Gln Pro Leu His Phe Ile Pro Arg Lys Gln Leu Cys Asp Gly Glu 
65                  70                  75                  80  


Leu Asp Cys Pro Leu Gly Glu Asp Glu Glu His Cys Val Lys Ser Phe 
                85                  90                  95      


Pro Glu Gly Pro Ala Val Ala Val Arg Leu Ser Lys Asp Arg Ser Thr 
            100                 105                 110         


Leu Gln Val Leu Asp Ser Ala Thr Gly Asn Trp Phe Ser Ala Cys Phe 
        115                 120                 125             


Asp Asn Phe Thr Glu Ala Leu Ala Glu Thr Ala Cys Arg Gln Met Gly 
    130                 135                 140                 


Tyr Ser Arg Ala Val Glu Ile Gly Pro Asp Gln Asp Leu Asp Val Val 
145                 150                 155                 160 


Glu Ile Thr Glu Asn Ser Gln Glu Leu Arg Met Arg Asn Ser Ser Gly 
                165                 170                 175     


Pro Cys Leu Ser Gly Ser Leu Val Ser Leu His Cys Leu Ala Cys Gly 
            180                 185                 190         


Lys Ser Leu Lys Thr Pro Arg Val Val Gly Gly Glu Glu Ala Ser Val 
        195                 200                 205             


Asp Ser Trp Pro Trp Gln Val Ser Ile Gln Tyr Asp Lys Gln His Val 
    210                 215                 220                 


Cys Gly Gly Ser Ile Leu Asp Pro His Trp Val Leu Thr Ala Ala His 
225                 230                 235                 240 


Cys Phe Arg Lys His Thr Asp Val Phe Asn Trp Lys Val Arg Ala Gly 
                245                 250                 255     


Ser Asp Lys Leu Gly Ser Phe Pro Ser Leu Ala Val Ala Lys Ile Ile 
            260                 265                 270         


Ile Ile Glu Phe Asn Pro Met Tyr Pro Lys Asp Asn Asp Ile Ala Leu 
        275                 280                 285             


Met Lys Leu Gln Phe Pro Leu Thr Phe Ser Gly Thr Val Arg Pro Ile 
    290                 295                 300                 


Cys Leu Pro Phe Phe Asp Glu Glu Leu Thr Pro Ala Thr Pro Leu Trp 
305                 310                 315                 320 


Ile Ile Gly Trp Gly Phe Thr Lys Gln Asn Gly Gly Lys Met Ser Asp 
                325                 330                 335     


Ile Leu Leu Gln Ala Ser Val Gln Val Ile Asp Ser Thr Arg Cys Asn 
            340                 345                 350         


Ala Asp Asp Ala Tyr Gln Gly Glu Val Thr Glu Lys Met Met Cys Ala 
        355                 360                 365             


Gly Ile Pro Glu Gly Gly Val Asp Thr Cys Gln Gly Asp Ser Gly Gly 
    370                 375                 380                 


Pro Leu Met Tyr Gln Ser Asp Gln Trp His Val Val Gly Ile Val Ser 
385                 390                 395                 400 


Trp Gly Tyr Gly Cys Gly Gly Pro Ser Thr Pro Gly Val Tyr Thr Lys 
                405                 410                 415     


Val Ser Ala Tyr Leu Asn Trp Ile Tyr Asn Val Trp Lys Ala Glu Leu 
            420                 425                 430         


<210>  1085
<211>  1953
<212>  PRT
<213>  Homo sapiens

<400>  1085

Met Gly Val Lys Lys Lys Lys Glu Met Gln Val Ala Ala Leu Thr Ile 
1               5                   10                  15      


Cys His Gln Asp Leu Glu Thr Leu Lys Ser Phe Ala Asp Val Glu Gly 
            20                  25                  30          


Lys Asn Leu Ala Ser Leu Leu Leu His Cys Val Gln Leu Thr Asp Gly 
        35                  40                  45              


Val Ser Gln Ile His Tyr Ile Lys Gln Ile Val Pro Leu Leu Glu Lys 
    50                  55                  60                  


Ala Asp Lys Asn Gly Met Cys Asp Pro Thr Ile Gln Ser Cys Leu Asp 
65                  70                  75                  80  


Ile Leu Ala Gly Ile Tyr Leu Ser Leu Ser Leu Lys Asn Pro Leu Lys 
                85                  90                  95      


Lys Val Leu Ala Ser Ser Leu Asn Ser Leu Pro Asp Phe Phe Leu Pro 
            100                 105                 110         


Glu Ala Met His Arg Phe Thr Ser Arg Leu Gln Glu Glu Leu Asn Thr 
        115                 120                 125             


Thr Asp Leu Tyr Ser Tyr Arg Lys Val Thr Asp Asn Ile Ser Ser Cys 
    130                 135                 140                 


Met Glu Asn Phe Asn Leu Gly Arg Ala Ser Val Asn Asn Leu Leu Lys 
145                 150                 155                 160 


Asn Val Leu His Phe Leu Gln Lys Ser Leu Ile Glu Ile Leu Glu Glu 
                165                 170                 175     


Asn Arg Lys Cys Ala Gly Asn His Ile Ile Gln Thr Gln Leu Met Asn 
            180                 185                 190         


Asp Leu Leu Val Gly Ile Arg Val Ser Met Met Leu Val Gln Lys Val 
        195                 200                 205             


Gln Asp Phe Gln Gly Asn Leu Trp Lys Thr Ser Asp Ser Pro Ile Trp 
    210                 215                 220                 


Gln Asn Met Cys Gly Leu Leu Ser Ile Phe Thr Lys Val Leu Ser Asp 
225                 230                 235                 240 


Asp Asp Leu Leu Gln Thr Val Gln Ser Thr Ser Gly Leu Ala Ile Ile 
                245                 250                 255     


Leu Phe Ile Lys Thr Met Phe His Pro Ser Glu Lys Ile Pro His Leu 
            260                 265                 270         


Ile Ser Ser Val Leu Leu Arg Ser Val Asp Cys Thr Ser Val Pro Glu 
        275                 280                 285             


Trp Phe Met Ser Ser Cys Arg Ser Leu Cys Cys Gly Asp Ile Ser Gln 
    290                 295                 300                 


Ser Ala Val Leu Phe Leu Cys Gln Gly Thr Leu Ala Met Leu Asp Trp 
305                 310                 315                 320 


Gln Asn Gly Ser Met Gly Arg Ser Gly Glu Ala Leu Leu Leu Asp Thr 
                325                 330                 335     


Ala His Val Leu Phe Thr Leu Ser Ser Gln Ile Lys Glu Pro Thr Leu 
            340                 345                 350         


Glu Met Phe Leu Ser Arg Ile Leu Ala Ser Trp Thr Asn Ser Ala Ile 
        355                 360                 365             


Gln Val Leu Glu Ser Ser Ser Pro Ser Leu Thr Asp Ser Leu Asn Gly 
    370                 375                 380                 


Asn Ser Ser Ile Val Gly Arg Leu Leu Glu Tyr Val Tyr Thr His Trp 
385                 390                 395                 400 


Glu His Pro Leu Asp Ala Leu Arg His Gln Thr Lys Ile Met Phe Lys 
                405                 410                 415     


Asn Leu Leu Gln Met His Arg Leu Thr Val Glu Gly Ala Asp Phe Val 
            420                 425                 430         


Pro Asp Pro Phe Phe Val Glu Leu Thr Glu Ser Leu Leu Arg Leu Glu 
        435                 440                 445             


Trp His Ile Lys Gly Lys Tyr Thr Cys Leu Gly Cys Leu Val Glu Cys 
    450                 455                 460                 


Ile Gly Val Glu His Ile Leu Ala Ile Asp Lys Thr Ile Pro Ser Gln 
465                 470                 475                 480 


Ile Leu Glu Val Met Gly Asp Gln Ser Leu Val Pro Tyr Ala Ser Asp 
                485                 490                 495     


Leu Leu Glu Thr Met Phe Arg Asn His Lys Ser His Leu Lys Ser Gln 
            500                 505                 510         


Thr Ala Glu Ser Ser Trp Ile Asp Gln Trp His Glu Thr Trp Val Ser 
        515                 520                 525             


Pro Leu Leu Phe Ile Leu Cys Glu Gly Asn Leu Asp Gln Lys Ser Tyr 
    530                 535                 540                 


Val Ile Asp Tyr Tyr Leu Pro Lys Leu Leu Ser Tyr Ser Pro Glu Ser 
545                 550                 555                 560 


Leu Gln Tyr Met Val Lys Ile Leu Gln Thr Ser Ile Asp Ala Lys Thr 
                565                 570                 575     


Gly Gln Glu Gln Ser Phe Pro Ser Leu Gly Ser Cys Asn Ser Arg Gly 
            580                 585                 590         


Ala Leu Gly Ala Leu Met Ala Cys Leu Arg Ile Ala Arg Ala His Gly 
        595                 600                 605             


His Leu Gln Ser Ala Thr Asp Thr Trp Glu Asn Leu Val Ser Asp Ala 
    610                 615                 620                 


Arg Ile Lys Gln Gly Leu Ile His Gln His Cys Gln Val Arg Ile Asp 
625                 630                 635                 640 


Thr Leu Gly Leu Leu Cys Glu Ser Asn Arg Ser Thr Glu Ile Val Ser 
                645                 650                 655     


Met Glu Glu Met Gln Trp Ile Gln Phe Phe Ile Thr Tyr Asn Leu Asn 
            660                 665                 670         


Ser Gln Ser Pro Gly Val Arg Gln Gln Ile Cys Ser Leu Leu Lys Lys 
        675                 680                 685             


Leu Phe Cys Arg Ile Gln Glu Ser Ser Gln Val Leu Tyr Lys Leu Glu 
    690                 695                 700                 


Gln Ser Lys Ser Lys Arg Glu Pro Glu Asn Glu Leu Thr Lys Gln His 
705                 710                 715                 720 


Pro Ser Val Ser Leu Gln Gln Tyr Lys Asn Phe Met Ser Ser Ile Cys 
                725                 730                 735     


Asn Ser Leu Phe Glu Ala Leu Phe Pro Gly Ser Ser Tyr Ser Thr Arg 
            740                 745                 750         


Phe Ser Ala Leu Thr Ile Leu Gly Ser Ile Ala Glu Val Phe His Val 
        755                 760                 765             


Pro Glu Gly Arg Ile Tyr Thr Val Tyr Gln Leu Ser His Asp Ile Asp 
    770                 775                 780                 


Val Gly Arg Phe Gln Thr Leu Met Glu Cys Phe Thr Ser Thr Phe Glu 
785                 790                 795                 800 


Asp Val Lys Ile Leu Ala Phe Asp Leu Leu Met Lys Leu Ser Lys Thr 
                805                 810                 815     


Ala Val His Phe Gln Asp Ser Gly Lys Leu Gln Gly Leu Phe Gln Ala 
            820                 825                 830         


Ala Leu Glu Leu Ser Thr Ser Thr Lys Pro Tyr Asp Cys Val Thr Ala 
        835                 840                 845             


Ser Tyr Leu Leu Asn Phe Leu Ile Trp Gln Asp Ala Leu Pro Ser Ser 
    850                 855                 860                 


Leu Ser Ala Tyr Leu Thr Gln Gln Val Ala Cys Asp Asn Gly Asp Arg 
865                 870                 875                 880 


Pro Ala Ala Val Val Glu Arg Asn Thr Leu Met Val Ile Lys Cys Leu 
                885                 890                 895     


Met Glu Asn Leu Glu Glu Glu Val Ser Gln Ala Glu Asn Ser Leu Leu 
            900                 905                 910         


Gln Ala Ala Ala Ala Phe Pro Met Tyr Gly Arg Val His Cys Ile Thr 
        915                 920                 925             


Gly Ala Leu Gln Lys Leu Ser Leu Asn Ser Leu Gln Leu Val Ser Glu 
    930                 935                 940                 


Trp Arg Pro Val Val Glu Lys Leu Leu Leu Met Ser Tyr Arg Leu Ser 
945                 950                 955                 960 


Thr Val Val Ser Pro Val Ile Gln Ser Ser Ser Pro Glu Gly Leu Ile 
                965                 970                 975     


Pro Met Asp Thr Asp Ser Glu Ser Ala Ser Arg Leu Gln Met Ile Leu 
            980                 985                 990         


Asn Glu Ile Gln Pro Arg Asp Thr  Asn Asp Tyr Phe Asn  Gln Ala Lys 
        995                 1000                 1005             


Ile Leu  Lys Glu His Asp Ser  Phe Asp Met Lys Asp  Leu Asn Ala 
    1010                 1015                 1020             


Ser Val  Val Asn Ile Asp Thr  Ser Thr Glu Ile Lys  Gly Lys Glu 
    1025                 1030                 1035             


Val Lys  Thr Cys Asp Val Thr  Ala Gln Met Val Leu  Val Cys Cys 
    1040                 1045                 1050             


Trp Arg  Ser Met Lys Glu Val  Ala Leu Leu Leu Gly  Met Leu Cys 
    1055                 1060                 1065             


Gln Leu  Leu Pro Met Gln Pro  Val Pro Glu Ser Ser  Asp Gly Leu 
    1070                 1075                 1080             


Leu Thr  Val Glu Gln Val Lys  Glu Ile Gly Asp Tyr  Phe Lys Gln 
    1085                 1090                 1095             


His Leu  Leu Gln Ser Arg His  Arg Gly Ala Phe Glu  Leu Ala Tyr 
    1100                 1105                 1110             


Thr Gly  Phe Val Lys Leu Thr  Glu Val Leu Asn Arg  Cys Pro Asn 
    1115                 1120                 1125             


Val Ser  Leu Gln Lys Leu Pro  Glu Gln Trp Leu Trp  Ser Val Leu 
    1130                 1135                 1140             


Glu Glu  Ile Lys Cys Ser Asp  Pro Ser Ser Lys Leu  Cys Ala Thr 
    1145                 1150                 1155             


Arg Arg  Ser Ala Gly Ile Pro  Phe Tyr Ile Gln Ala  Leu Leu Ala 
    1160                 1165                 1170             


Ser Glu  Pro Lys Lys Gly Arg  Met Asp Leu Leu Lys  Ile Thr Met 
    1175                 1180                 1185             


Lys Glu  Leu Ile Ser Leu Ala  Gly Pro Thr Asp Asp  Ile Gln Ser 
    1190                 1195                 1200             


Thr Val  Pro Gln Val His Ala  Leu Asn Ile Leu Arg  Ala Leu Phe 
    1205                 1210                 1215             


Arg Asp  Thr Arg Leu Gly Glu  Asn Ile Ile Pro Tyr  Val Ala Asp 
    1220                 1225                 1230             


Gly Ala  Lys Ala Ala Ile Leu  Gly Phe Thr Ser Pro  Val Trp Ala 
    1235                 1240                 1245             


Val Arg  Asn Ser Ser Thr Leu  Leu Phe Ser Ala Leu  Ile Thr Arg 
    1250                 1255                 1260             


Ile Phe  Gly Val Lys Arg Ala  Lys Asp Glu His Ser  Lys Thr Asn 
    1265                 1270                 1275             


Arg Met  Thr Gly Arg Glu Phe  Phe Ser Arg Phe Pro  Glu Leu Tyr 
    1280                 1285                 1290             


Pro Phe  Leu Leu Lys Gln Leu  Glu Thr Val Ala Asn  Thr Val Asp 
    1295                 1300                 1305             


Ser Asp  Met Gly Glu Pro Asn  Arg His Pro Ser Met  Phe Leu Leu 
    1310                 1315                 1320             


Leu Leu  Val Leu Glu Arg Leu  Tyr Ala Ser Pro Met  Asp Gly Thr 
    1325                 1330                 1335             


Ser Ser  Ala Leu Ser Met Gly  Pro Phe Val Pro Phe  Ile Met Arg 
    1340                 1345                 1350             


Cys Gly  His Ser Pro Val Tyr  His Ser Arg Glu Met  Ala Ala Arg 
    1355                 1360                 1365             


Ala Leu  Val Pro Phe Val Met  Ile Asp His Ile Pro  Asn Thr Ile 
    1370                 1375                 1380             


Arg Thr  Leu Leu Ser Thr Leu  Pro Ser Cys Thr Asp  Gln Cys Phe 
    1385                 1390                 1395             


Arg Gln  Asn His Ile His Gly  Thr Leu Leu Gln Val  Phe His Leu 
    1400                 1405                 1410             


Leu Gln  Ala Tyr Ser Asp Ser  Lys His Gly Thr Asn  Ser Asp Phe 
    1415                 1420                 1425             


Gln His  Glu Leu Thr Asp Ile  Thr Val Cys Thr Lys  Ala Lys Leu 
    1430                 1435                 1440             


Trp Leu  Ala Lys Arg Gln Asn  Pro Cys Leu Val Thr  Arg Ala Val 
    1445                 1450                 1455             


Tyr Ile  Asp Ile Leu Phe Leu  Leu Thr Cys Cys Leu  Asn Arg Ser 
    1460                 1465                 1470             


Ala Lys  Asp Asn Gln Pro Val  Leu Glu Ser Leu Gly  Phe Trp Glu 
    1475                 1480                 1485             


Glu Val  Arg Gly Ile Ile Ser  Gly Ser Glu Leu Ile  Thr Gly Phe 
    1490                 1495                 1500             


Pro Trp  Ala Phe Lys Val Pro  Gly Leu Pro Gln Tyr  Leu Gln Ser 
    1505                 1510                 1515             


Leu Thr  Arg Leu Ala Ile Ala  Ala Val Trp Ala Ala  Ala Ala Lys 
    1520                 1525                 1530             


Ser Gly  Glu Arg Glu Thr Asn  Val Pro Ile Ser Phe  Ser Gln Leu 
    1535                 1540                 1545             


Leu Glu  Ser Ala Phe Pro Glu  Val Arg Ser Leu Thr  Leu Glu Ala 
    1550                 1555                 1560             


Leu Leu  Glu Lys Phe Leu Ala  Ala Ala Ser Gly Leu  Gly Glu Lys 
    1565                 1570                 1575             


Gly Val  Pro Pro Leu Leu Cys  Asn Met Gly Glu Lys  Phe Leu Leu 
    1580                 1585                 1590             


Leu Ala  Met Lys Glu Asn His  Pro Glu Cys Phe Cys  Lys Ile Leu 
    1595                 1600                 1605             


Lys Ile  Leu His Cys Met Asp  Pro Gly Glu Trp Leu  Pro Gln Thr 
    1610                 1615                 1620             


Glu His  Cys Val His Leu Thr  Pro Lys Glu Phe Leu  Ile Trp Thr 
    1625                 1630                 1635             


Met Asp  Ile Ala Ser Asn Glu  Arg Ser Glu Ile Gln  Ser Val Ala 
    1640                 1645                 1650             


Leu Arg  Leu Ala Ser Lys Val  Ile Ser His His Met  Gln Thr Cys 
    1655                 1660                 1665             


Val Glu  Asn Arg Glu Leu Ile  Ala Ala Glu Leu Lys  Gln Trp Val 
    1670                 1675                 1680             


Gln Leu  Val Ile Leu Ser Cys  Glu Asp His Leu Pro  Thr Glu Ser 
    1685                 1690                 1695             


Arg Leu  Ala Val Val Glu Val  Leu Thr Ser Thr Thr  Pro Leu Phe 
    1700                 1705                 1710             


Leu Thr  Asn Pro His Pro Ile  Leu Glu Leu Gln Asp  Thr Leu Ala 
    1715                 1720                 1725             


Leu Trp  Lys Cys Val Leu Thr  Leu Leu Gln Ser Glu  Glu Gln Ala 
    1730                 1735                 1740             


Val Arg  Asp Ala Ala Thr Glu  Thr Val Thr Thr Ala  Met Ser Gln 
    1745                 1750                 1755             


Glu Asn  Thr Cys Gln Ser Thr  Glu Phe Ala Phe Cys  Gln Val Asp 
    1760                 1765                 1770             


Ala Ser  Ile Ala Leu Ala Leu  Ala Leu Ala Val Leu  Cys Asp Leu 
    1775                 1780                 1785             


Leu Gln  Gln Trp Asp Gln Leu  Ala Pro Gly Leu Pro  Ile Leu Leu 
    1790                 1795                 1800             


Gly Trp  Leu Leu Gly Glu Ser  Asp Asp Leu Val Ala  Cys Val Glu 
    1805                 1810                 1815             


Ser Met  His Gln Val Glu Glu  Asp Tyr Leu Phe Glu  Lys Ala Glu 
    1820                 1825                 1830             


Val Asn  Phe Trp Ala Glu Thr  Leu Ile Phe Val Lys  Tyr Leu Cys 
    1835                 1840                 1845             


Lys His  Leu Phe Cys Leu Leu  Ser Lys Ser Gly Trp  Arg Pro Pro 
    1850                 1855                 1860             


Ser Pro  Glu Met Leu Cys His  Leu Gln Arg Met Val  Ser Glu Gln 
    1865                 1870                 1875             


Cys His  Leu Leu Ser Gln Phe  Phe Arg Glu Leu Pro  Pro Ala Ala 
    1880                 1885                 1890             


Glu Phe  Val Lys Thr Val Glu  Phe Thr Arg Leu Arg  Ile Gln Glu 
    1895                 1900                 1905             


Glu Arg  Thr Leu Ala Cys Leu  Arg Leu Leu Ala Phe  Leu Glu Gly 
    1910                 1915                 1920             


Lys Glu  Gly Glu Asp Thr Leu  Val Leu Ser Val Trp  Asp Ser Tyr 
    1925                 1930                 1935             


Ala Glu  Ser Arg Gln Leu Thr  Leu Pro Arg Thr Glu  Ala Ala Cys 
    1940                 1945                 1950             


<210>  1086
<211>  561
<212>  PRT
<213>  Homo sapiens

<400>  1086

Met Ser Thr Glu Arg Thr Ser Trp Thr Ser Leu Ser Thr Ile Gln Lys 
1               5                   10                  15      


Ile Ala Leu Gly Leu Gly Ile Pro Ala Ser Ala Thr Val Ala Tyr Ile 
            20                  25                  30          


Leu Tyr Arg Arg Tyr Arg Glu Ser Arg Glu Glu Arg Leu Thr Phe Val 
        35                  40                  45              


Gly Glu Asp Asp Ile Glu Ile Glu Met Arg Val Pro Gln Glu Ala Val 
    50                  55                  60                  


Lys Leu Ile Ile Gly Arg Gln Gly Ala Asn Ile Lys Gln Leu Arg Lys 
65                  70                  75                  80  


Gln Thr Gly Ala Arg Ile Asp Val Asp Thr Glu Asp Val Gly Asp Glu 
                85                  90                  95      


Arg Val Leu Leu Ile Ser Gly Phe Pro Val Gln Val Cys Lys Ala Lys 
            100                 105                 110         


Ala Ala Ile His Gln Ile Leu Thr Glu Asn Thr Pro Val Ser Glu Gln 
        115                 120                 125             


Leu Ser Val Pro Gln Arg Ser Val Gly Arg Ile Ile Gly Arg Gly Gly 
    130                 135                 140                 


Glu Thr Ile Arg Ser Ile Cys Lys Ala Ser Gly Ala Lys Ile Thr Cys 
145                 150                 155                 160 


Asp Lys Glu Ser Glu Gly Thr Leu Leu Leu Ser Arg Leu Ile Lys Ile 
                165                 170                 175     


Ser Gly Thr Gln Lys Glu Val Ala Ala Ala Lys His Leu Ile Leu Glu 
            180                 185                 190         


Lys Val Ser Glu Asp Glu Glu Leu Arg Lys Arg Ile Ala His Ser Ala 
        195                 200                 205             


Glu Thr Arg Val Pro Arg Lys Gln Pro Ile Ser Val Arg Arg Glu Asp 
    210                 215                 220                 


Met Thr Glu Pro Gly Gly Ala Gly Glu Pro Ala Leu Trp Lys Asn Thr 
225                 230                 235                 240 


Ser Ser Ser Met Glu Pro Thr Ala Pro Leu Val Thr Pro Pro Pro Lys 
                245                 250                 255     


Gly Gly Gly Asp Met Ala Val Val Val Ser Lys Glu Gly Ser Trp Glu 
            260                 265                 270         


Lys Pro Ser Asp Asp Ser Phe Gln Lys Ser Glu Ala Gln Ala Ile Pro 
        275                 280                 285             


Glu Met Pro Met Phe Glu Ile Pro Ser Pro Asp Phe Ser Phe His Ala 
    290                 295                 300                 


Asp Glu Tyr Leu Glu Val Tyr Val Ser Ala Ser Glu His Pro Asn His 
305                 310                 315                 320 


Phe Trp Ile Gln Ile Val Gly Ser Arg Ser Leu Gln Leu Asp Lys Leu 
                325                 330                 335     


Val Asn Glu Met Thr Gln His Tyr Glu Asn Ser Val Pro Glu Asp Leu 
            340                 345                 350         


Thr Val His Val Gly Asp Ile Val Ala Ala Pro Leu Pro Thr Asn Gly 
        355                 360                 365             


Ser Trp Tyr Arg Ala Arg Val Leu Gly Thr Leu Glu Asn Gly Asn Leu 
    370                 375                 380                 


Asp Leu Tyr Phe Val Asp Phe Gly Asp Asn Gly Asp Cys Pro Leu Lys 
385                 390                 395                 400 


Asp Leu Arg Ala Leu Arg Ser Asp Phe Leu Ser Leu Pro Phe Gln Ala 
                405                 410                 415     


Ile Glu Cys Ser Leu Ala Arg Ile Ala Pro Ser Gly Asp Gln Trp Glu 
            420                 425                 430         


Glu Glu Ala Leu Asp Glu Phe Asp Arg Leu Thr His Cys Ala Asp Trp 
        435                 440                 445             


Lys Pro Leu Val Ala Lys Ile Ser Ser Tyr Val Gln Thr Gly Ile Ser 
    450                 455                 460                 


Thr Trp Pro Lys Ile Tyr Leu Tyr Asp Thr Ser Asn Gly Lys Lys Leu 
465                 470                 475                 480 


Asp Ile Gly Leu Glu Leu Val His Lys Gly Tyr Ala Ile Glu Leu Pro 
                485                 490                 495     


Glu Asp Ile Glu Glu Asn Arg Ala Val Pro Asp Met Leu Lys Asp Met 
            500                 505                 510         


Ala Thr Glu Thr Asp Ala Ser Leu Ser Thr Leu Leu Thr Glu Thr Lys 
        515                 520                 525             


Lys Ser Ser Gly Glu Ile Thr His Thr Leu Ser Cys Leu Ser Leu Ser 
    530                 535                 540                 


Glu Ala Ala Ser Met Ser Gly Asp Asp Asn Leu Glu Asp Asp Tyr Leu 
545                 550                 555                 560 


Leu 
    


<210>  1087
<211>  516
<212>  PRT
<213>  Homo sapiens

<400>  1087

Met Ser Thr Glu Arg Thr Ser Trp Thr Ser Leu Ser Thr Ile Gln Lys 
1               5                   10                  15      


Ile Ala Leu Gly Leu Gly Ile Pro Ala Ser Ala Thr Val Ala Tyr Ile 
            20                  25                  30          


Leu Tyr Arg Arg Tyr Arg Glu Ser Arg Glu Glu Arg Leu Thr Phe Val 
        35                  40                  45              


Gly Glu Asp Asp Ile Glu Ile Glu Met Arg Val Pro Gln Glu Ala Val 
    50                  55                  60                  


Lys Leu Ile Ile Gly Arg Gln Gly Ala Asn Ile Lys Gln Leu Arg Lys 
65                  70                  75                  80  


Gln Thr Gly Ala Arg Ile Asp Val Asp Thr Glu Asp Val Gly Asp Glu 
                85                  90                  95      


Arg Val Leu Leu Ile Ser Gly Phe Pro Val Gln Ala Ser Gly Ala Lys 
            100                 105                 110         


Ile Thr Cys Asp Lys Glu Ser Glu Gly Thr Leu Leu Leu Ser Arg Leu 
        115                 120                 125             


Ile Lys Ile Ser Gly Thr Gln Lys Glu Val Ala Ala Ala Lys His Leu 
    130                 135                 140                 


Ile Leu Glu Lys Val Ser Glu Asp Glu Glu Leu Arg Lys Arg Ile Ala 
145                 150                 155                 160 


His Ser Ala Glu Thr Arg Val Pro Arg Lys Gln Pro Ile Ser Val Arg 
                165                 170                 175     


Arg Glu Asp Met Thr Glu Pro Gly Gly Ala Gly Glu Pro Ala Leu Trp 
            180                 185                 190         


Lys Asn Thr Ser Ser Ser Met Glu Pro Thr Ala Pro Leu Val Thr Pro 
        195                 200                 205             


Pro Pro Lys Gly Gly Gly Asp Met Ala Val Val Val Ser Lys Glu Gly 
    210                 215                 220                 


Ser Trp Glu Lys Pro Ser Asp Asp Ser Phe Gln Lys Ser Glu Ala Gln 
225                 230                 235                 240 


Ala Ile Pro Glu Met Pro Met Phe Glu Ile Pro Ser Pro Asp Phe Ser 
                245                 250                 255     


Phe His Ala Asp Glu Tyr Leu Glu Val Tyr Val Ser Ala Ser Glu His 
            260                 265                 270         


Pro Asn His Phe Trp Ile Gln Ile Val Gly Ser Arg Ser Leu Gln Leu 
        275                 280                 285             


Asp Lys Leu Val Asn Glu Met Thr Gln His Tyr Glu Asn Ser Val Pro 
    290                 295                 300                 


Glu Asp Leu Thr Val His Val Gly Asp Ile Val Ala Ala Pro Leu Pro 
305                 310                 315                 320 


Thr Asn Gly Ser Trp Tyr Arg Ala Arg Val Leu Gly Thr Leu Glu Asn 
                325                 330                 335     


Gly Asn Leu Asp Leu Tyr Phe Val Asp Phe Gly Asp Asn Gly Asp Cys 
            340                 345                 350         


Pro Leu Lys Asp Leu Arg Ala Leu Arg Ser Asp Phe Leu Ser Leu Pro 
        355                 360                 365             


Phe Gln Ala Ile Glu Cys Ser Leu Ala Arg Ile Ala Pro Ser Gly Asp 
    370                 375                 380                 


Gln Trp Glu Glu Glu Ala Leu Asp Glu Phe Asp Arg Leu Thr His Cys 
385                 390                 395                 400 


Ala Asp Trp Lys Pro Leu Val Ala Lys Ile Ser Ser Tyr Val Gln Thr 
                405                 410                 415     


Gly Ile Ser Thr Trp Pro Lys Ile Tyr Leu Tyr Asp Thr Ser Asn Gly 
            420                 425                 430         


Lys Lys Leu Asp Ile Gly Leu Glu Leu Val His Lys Gly Tyr Ala Ile 
        435                 440                 445             


Glu Leu Pro Glu Asp Ile Glu Glu Asn Arg Ala Val Pro Asp Met Leu 
    450                 455                 460                 


Lys Asp Met Ala Thr Glu Thr Asp Ala Ser Leu Ser Thr Leu Leu Thr 
465                 470                 475                 480 


Glu Thr Lys Lys Ser Ser Gly Glu Ile Thr His Thr Leu Ser Cys Leu 
                485                 490                 495     


Ser Leu Ser Glu Ala Ala Ser Met Ser Gly Asp Asp Asn Leu Glu Asp 
            500                 505                 510         


Asp Tyr Leu Leu 
        515     


<210>  1088
<211>  561
<212>  PRT
<213>  Homo sapiens

<400>  1088

Met Ser Thr Glu Arg Thr Ser Trp Thr Ser Leu Ser Thr Ile Gln Lys 
1               5                   10                  15      


Ile Ala Leu Gly Leu Gly Ile Pro Ala Ser Ala Thr Val Ala Tyr Ile 
            20                  25                  30          


Leu Tyr Arg Arg Tyr Arg Glu Ser Arg Glu Glu Arg Leu Thr Phe Val 
        35                  40                  45              


Gly Glu Asp Asp Ile Glu Ile Glu Met Arg Val Pro Gln Glu Ala Val 
    50                  55                  60                  


Lys Leu Ile Ile Gly Arg Gln Gly Ala Asn Ile Lys Gln Leu Arg Lys 
65                  70                  75                  80  


Gln Thr Gly Ala Arg Ile Asp Val Asp Thr Glu Asp Val Gly Asp Glu 
                85                  90                  95      


Arg Val Leu Leu Ile Ser Gly Phe Pro Val Gln Val Cys Lys Ala Lys 
            100                 105                 110         


Ala Ala Ile His Gln Ile Leu Thr Glu Asn Thr Pro Val Ser Glu Gln 
        115                 120                 125             


Leu Ser Val Pro Gln Arg Ser Val Gly Arg Ile Ile Gly Arg Gly Gly 
    130                 135                 140                 


Glu Thr Ile Arg Ser Ile Cys Lys Ala Ser Gly Ala Lys Ile Thr Cys 
145                 150                 155                 160 


Asp Lys Glu Ser Glu Gly Thr Leu Leu Leu Ser Arg Leu Ile Lys Ile 
                165                 170                 175     


Ser Gly Thr Gln Lys Glu Val Ala Ala Ala Lys His Leu Ile Leu Glu 
            180                 185                 190         


Lys Val Ser Glu Asp Glu Glu Leu Arg Lys Arg Ile Ala His Ser Ala 
        195                 200                 205             


Glu Thr Arg Val Pro Arg Lys Gln Pro Ile Ser Val Arg Arg Glu Asp 
    210                 215                 220                 


Met Thr Glu Pro Gly Gly Ala Gly Glu Pro Ala Leu Trp Lys Asn Thr 
225                 230                 235                 240 


Ser Ser Ser Met Glu Pro Thr Ala Pro Leu Val Thr Pro Pro Pro Lys 
                245                 250                 255     


Gly Gly Gly Asp Met Ala Val Val Val Ser Lys Glu Gly Ser Trp Glu 
            260                 265                 270         


Lys Pro Ser Asp Asp Ser Phe Gln Lys Ser Glu Ala Gln Ala Ile Pro 
        275                 280                 285             


Glu Met Pro Met Phe Glu Ile Pro Ser Pro Asp Phe Ser Phe His Ala 
    290                 295                 300                 


Asp Glu Tyr Leu Glu Val Tyr Val Ser Ala Ser Glu His Pro Asn His 
305                 310                 315                 320 


Phe Trp Ile Gln Ile Val Gly Ser Arg Ser Leu Gln Leu Asp Lys Leu 
                325                 330                 335     


Val Asn Glu Met Thr Gln His Tyr Glu Asn Ser Val Pro Glu Asp Leu 
            340                 345                 350         


Thr Val His Val Gly Asp Ile Val Ala Ala Pro Leu Pro Thr Asn Gly 
        355                 360                 365             


Ser Trp Tyr Arg Ala Arg Val Leu Gly Thr Leu Glu Asn Gly Asn Leu 
    370                 375                 380                 


Asp Leu Tyr Phe Val Asp Phe Gly Asp Asn Gly Asp Cys Pro Leu Lys 
385                 390                 395                 400 


Asp Leu Arg Ala Leu Arg Ser Asp Phe Leu Ser Leu Pro Phe Gln Ala 
                405                 410                 415     


Ile Glu Cys Ser Leu Ala Arg Ile Ala Pro Ser Gly Asp Gln Trp Glu 
            420                 425                 430         


Glu Glu Ala Leu Asp Glu Phe Asp Arg Leu Thr His Cys Ala Asp Trp 
        435                 440                 445             


Lys Pro Leu Val Ala Lys Ile Ser Ser Tyr Val Gln Thr Gly Ile Ser 
    450                 455                 460                 


Thr Trp Pro Lys Ile Tyr Leu Tyr Asp Thr Ser Asn Gly Lys Lys Leu 
465                 470                 475                 480 


Asp Ile Gly Leu Glu Leu Val His Lys Gly Tyr Ala Ile Glu Leu Pro 
                485                 490                 495     


Glu Asp Ile Glu Glu Asn Arg Ala Val Pro Asp Met Leu Lys Asp Met 
            500                 505                 510         


Ala Thr Glu Thr Asp Ala Ser Leu Ser Thr Leu Leu Thr Glu Thr Lys 
        515                 520                 525             


Lys Ser Ser Gly Glu Ile Thr His Thr Leu Ser Cys Leu Ser Leu Ser 
    530                 535                 540                 


Glu Ala Ala Ser Met Ser Gly Asp Asp Asn Leu Glu Asp Asp Tyr Leu 
545                 550                 555                 560 


Leu 
    


<210>  1089
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  1089

Met Ala Ala Ala Thr Arg Gly Cys Arg Pro Trp Gly Ser Leu Leu Gly 
1               5                   10                  15      


Leu Leu Gly Leu Val Ser Ala Ala Ala Ala Ala Trp Asp Leu Ala Ser 
            20                  25                  30          


Leu Arg Cys Thr Leu Gly Ala Phe Cys Glu Cys Asp Phe Arg Pro Asp 
        35                  40                  45              


Leu Pro Gly Leu Glu Cys Asp Leu Ala Gln His Leu Ala Gly Gln His 
    50                  55                  60                  


Leu Ala Lys Ala Leu Val Val Lys Ala Leu Lys Ala Phe Val Arg Asp 
65                  70                  75                  80  


Pro Ala Pro Thr Lys Pro Leu Val Leu Ser Leu His Gly Trp Thr Gly 
                85                  90                  95      


Thr Gly Lys Ser Tyr Val Ser Ser Leu Leu Ala His Tyr Leu Phe Gln 
            100                 105                 110         


Gly Gly Leu Arg Ser Pro Arg Val His His Phe Ser Pro Val Leu His 
        115                 120                 125             


Phe Pro His Pro Ser His Ile Glu Arg Tyr Lys Lys Asp Leu Lys Ser 
    130                 135                 140                 


Trp Val Gln Gly Asn Leu Thr Ala Cys Gly Arg Ser Leu Phe Leu Phe 
145                 150                 155                 160 


Asp Glu Met Asp Lys Met Pro Pro Gly Leu Met Glu Val Leu Arg Pro 
                165                 170                 175     


Phe Leu Gly Ser Ser Trp Val Val Tyr Gly Thr Asn Tyr Arg Lys Ala 
            180                 185                 190         


Ile Phe Ile Phe Ile Ser Asn Thr Gly Gly Glu Gln Ile Asn Gln Val 
        195                 200                 205             


Ala Leu Glu Ala Trp Arg Ser Arg Arg Asp Arg Glu Glu Ile Leu Leu 
    210                 215                 220                 


Gln Glu Leu Glu Pro Val Ile Ser Arg Ala Val Leu Asp Asn Pro His 
225                 230                 235                 240 


His Gly Phe Ser Asn Ser Gly Ile Met Glu Glu Arg Leu Leu Asp Ala 
                245                 250                 255     


Val Val Pro Phe Leu Pro Leu Gln Arg His His Val Arg His Cys Val 
            260                 265                 270         


Leu Asn Glu Leu Ala Gln Leu Gly Leu Glu Pro Arg Asp Glu Val Val 
        275                 280                 285             


Gln Ala Val Leu Asp Ser Thr Thr Phe Phe Pro Glu Asp Glu Gln Leu 
    290                 295                 300                 


Phe Ser Ser Asn Gly Cys Lys Thr Val Ala Ser Arg Ile Ala Phe Phe 
305                 310                 315                 320 


Leu 
    


<210>  1090
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  1090

Met Lys Thr Leu Pro Ala Met Leu Gly Thr Gly Lys Leu Phe Trp Val 
1               5                   10                  15      


Phe Phe Leu Ile Pro Tyr Leu Asp Ile Trp Asn Ile His Gly Lys Glu 
            20                  25                  30          


Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu His Ser Ile 
        35                  40                  45              


Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val Lys Tyr Cys Ala 
    50                  55                  60                  


Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn Gly Thr Thr Cys Val 
65                  70                  75                  80  


Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn Ile Ser 
                85                  90                  95      


Phe Phe Ile Leu His Phe Glu Pro Val Leu Pro Asn Asp Asn Gly Ser 
            100                 105                 110         


Tyr Arg Cys Ser Ala Asn Phe Gln Ser Asn Leu Ile Glu Ser His Ser 
        115                 120                 125             


Thr Thr Leu Tyr Val Thr Gly Lys Gln Asn Glu Leu Ser Asp Thr Ala 
    130                 135                 140                 


Gly Arg Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln Thr 
145                 150                 155                 160 


Glu Ala Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Thr Gly 
                165                 170                 175     


Ile Tyr Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly Ser 
            180                 185                 190         


Glu Val Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile Val 
        195                 200                 205             


Tyr Ala Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser Arg Leu Ala 
    210                 215                 220                 


Arg Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val Arg 
225                 230                 235                 240 


Ser 
    


<210>  1091
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  1091

Met Ala Pro Arg Ala Leu Pro Gly Ser Ala Val Leu Ala Ala Ala Val 
1               5                   10                  15      


Phe Val Gly Gly Ala Val Ser Ser Pro Leu Val Ala Pro Asp Asn Gly 
            20                  25                  30          


Ser Ser Arg Thr Leu His Ser Arg Thr Glu Thr Thr Pro Ser Pro Ser 
        35                  40                  45              


Asn Asp Thr Gly Asn Gly His Pro Glu Tyr Ile Ala Tyr Ala Leu Val 
    50                  55                  60                  


Pro Val Phe Phe Ile Met Gly Leu Phe Gly Val Leu Ile Cys His Leu 
65                  70                  75                  80  


Leu Lys Lys Lys Gly Tyr Arg Cys Thr Thr Glu Ala Glu Gln Asp Ile 
                85                  90                  95      


Glu Glu Glu Lys Val Glu Lys Ile Glu Leu Asn Asp Ser Val Asn Glu 
            100                 105                 110         


Asn Ser Asp Thr Val Gly Gln Ile Val His Tyr Ile Met Lys Asn Glu 
        115                 120                 125             


Ala Asn Ala Asp Val Leu Lys Ala Met Val Ala Asp Asn Ser Leu Tyr 
    130                 135                 140                 


Asp Pro Glu Ser Pro Val Thr Pro Ser Thr Pro Gly Ser Pro Pro Val 
145                 150                 155                 160 


Ser Pro Gly Pro Leu Ser Pro Gly Gly Thr Pro Gly Lys His Val Cys 
                165                 170                 175     


Gly His His Leu His Thr Val Gly Gly Val Val Glu Arg Asp Val Cys 
            180                 185                 190         


His Arg Cys Arg His Lys Arg Trp His Phe Ile Lys Pro Thr Asn Lys 
        195                 200                 205             


Ser Arg Glu Ser Arg Pro Arg Arg Gln Gly Glu Val Thr Val Leu Ser 
    210                 215                 220                 


Val Gly Arg Phe Arg Val Thr Lys Val Glu His Lys Ser Asn Gln Lys 
225                 230                 235                 240 


Glu Arg Arg Ser Leu Met Ser Val Ser Gly Ala Glu Thr Val Asn Gly 
                245                 250                 255     


Glu Val Pro Ala Thr Pro Val Lys Arg Glu Arg Ser Gly Thr Glu 
            260                 265                 270     


<210>  1092
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  1092

Met Ala Pro Arg Ala Leu Pro Gly Ser Ala Val Leu Ala Ala Ala Val 
1               5                   10                  15      


Phe Val Gly Gly Ala Val Ser Ser Pro Leu Val Ala Pro Asp Asn Gly 
            20                  25                  30          


Ser Ser Arg Thr Leu His Ser Arg Thr Glu Thr Thr Pro Ser Pro Ser 
        35                  40                  45              


Asn Asp Thr Gly Asn Gly His Pro Glu Tyr Ile Ala Tyr Ala Leu Val 
    50                  55                  60                  


Pro Val Phe Phe Ile Met Gly Leu Phe Gly Val Leu Ile Cys His Leu 
65                  70                  75                  80  


Leu Lys Lys Lys Gly Tyr Arg Cys Thr Thr Glu Ala Glu Gln Asp Ile 
                85                  90                  95      


Glu Glu Glu Lys Val Glu Lys Ile Glu Leu Asn Asp Ser Val Asn Glu 
            100                 105                 110         


Asn Ser Asp Thr Val Gly Gln Ile Val His Tyr Ile Met Lys Asn Glu 
        115                 120                 125             


Ala Asn Ala Asp Val Leu Lys Ala Met Val Ala Asp Asn Ser Leu Tyr 
    130                 135                 140                 


Asp Pro Glu Ser Pro Val Thr Pro Ser Thr Pro Gly Ser Pro Pro Val 
145                 150                 155                 160 


Ser Pro Gly Pro Leu Ser Pro Gly Gly Thr Pro Gly Lys His Val Cys 
                165                 170                 175     


Gly His His Leu His Thr Val Gly Gly Val Val Glu Arg Asp Val Cys 
            180                 185                 190         


His Arg Cys Arg His Lys Arg Trp His Phe Ile Lys Pro Thr Asn Lys 
        195                 200                 205             


Ser Arg Glu Ser Arg Pro Arg Arg Gln Gly Glu Val Thr Val Leu Ser 
    210                 215                 220                 


Val Gly Arg Phe Arg Val Thr Lys Val Glu His Lys Ser Asn Gln Lys 
225                 230                 235                 240 


Glu Arg Arg Ser Leu Met Ser Val Ser Gly Ala Glu Thr Val Asn Gly 
                245                 250                 255     


Glu Val Pro Ala Thr Pro Val Lys Arg Glu Arg Ser Gly Thr Glu 
            260                 265                 270     


<210>  1093
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  1093

Met Trp Ser His Leu Asn Arg Leu Leu Phe Trp Ser Ile Phe Ser Ser 
1               5                   10                  15      


Val Thr Cys Arg Lys Ala Val Leu Asp Cys Glu Ala Met Lys Thr Asn 
            20                  25                  30          


Glu Phe Pro Ser Pro Cys Leu Asp Ser Lys Thr Lys Val Val Met Lys 
        35                  40                  45              


Gly Gln Asn Val Ser Met Phe Cys Ser His Lys Asn Lys Ser Leu Gln 
    50                  55                  60                  


Ile Thr Tyr Ser Leu Phe Arg Arg Lys Thr His Leu Gly Thr Gln Asp 
65                  70                  75                  80  


Gly Lys Gly Glu Pro Ala Ile Phe Asn Leu Ser Ile Thr Glu Ala His 
                85                  90                  95      


Glu Ser Gly Pro Tyr Lys Cys Lys Ala Gln Val Thr Ser Cys Ser Lys 
            100                 105                 110         


Tyr Ser Arg Asp Phe Ser Phe Thr Ile Val Asp Pro Val Thr Ser Pro 
        115                 120                 125             


Val Leu Asn Ile Met Val Ile Gln Thr Glu Thr Asp Arg His Ile Thr 
    130                 135                 140                 


Leu His Cys Leu Ser Val Asn Gly Ser Leu Pro Ile Asn Tyr Thr Phe 
145                 150                 155                 160 


Phe Glu Asn His Val Ala Ile Ser Pro Ala Ile Ser Lys Tyr Asp Arg 
                165                 170                 175     


Glu Pro Ala Glu Phe Asn Leu Thr Lys Lys Asn Pro Gly Glu Glu Glu 
            180                 185                 190         


Glu Tyr Arg Cys Glu Ala Lys Asn Arg Leu Pro Asn Tyr Ala Thr Tyr 
        195                 200                 205             


Ser His Pro Val Thr Met Pro Ser Thr Gly Gly Asp Ser Cys Pro Phe 
    210                 215                 220                 


Cys Leu Lys Leu Leu Leu Pro Gly Leu Leu Leu Leu Leu Val Val Ile 
225                 230                 235                 240 


Ile Leu Ile Leu Ala Phe Trp Val Leu Pro Lys Tyr Lys Thr Arg Lys 
                245                 250                 255     


Ala Met Arg Asn Asn Val Pro Arg Asp Arg Gly Asp Thr Ala Met Glu 
            260                 265                 270         


Val Gly Ile Tyr Ala Asn Ile Leu Glu Lys Gln Ala Lys Glu Glu Ser 
        275                 280                 285             


Val Pro Glu Val Gly Ser Arg Pro Cys Val Ser Thr Ala Gln Asp Glu 
    290                 295                 300                 


Ala Lys His Ser Gln Glu Leu Gln Tyr Ala Thr Pro Val Phe Gln Glu 
305                 310                 315                 320 


Val Ala Pro Arg Glu Gln Glu Ala Cys Asp Ser Tyr Lys Ser Gly Tyr 
                325                 330                 335     


Val Tyr Ser Glu Leu Asn Phe 
            340             


<210>  1094
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  1094

Met Gln Arg Leu Pro Ala Ala Thr Arg Ala Thr Leu Ile Leu Ser Leu 
1               5                   10                  15      


Ala Phe Ala Ser Leu His Ser Ala Cys Ser Ala Glu Ala Ser Ser Ser 
            20                  25                  30          


Asn Ser Ser Ser Leu Thr Ala His His Pro Asp Pro Gly Thr Leu Glu 
        35                  40                  45              


Gln Cys Leu Asn Val Asp Phe Cys Pro Gln Ala Ala Arg Cys Cys Arg 
    50                  55                  60                  


Thr Gly Val Asp Glu Tyr Gly Trp Ile Ala Ala Ala Val Gly Trp Ser 
65                  70                  75                  80  


Leu Trp Phe Leu Thr Leu Ile Leu Leu Cys Val Asp Lys Leu Met Lys 
                85                  90                  95      


Leu Thr Pro Asp Glu Pro Lys Asp Leu Gln Ala 
            100                 105         


<210>  1095
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  1095

Met Leu Arg Ala Val Gly Ser Leu Leu Arg Leu Gly Arg Gly Leu Thr 
1               5                   10                  15      


Val Arg Cys Gly Pro Gly Ala Pro Leu Glu Ala Thr Arg Arg Pro Ala 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Gly Leu Pro Cys Tyr Ser Ser Gly Gly Ala 
        35                  40                  45              


Pro Ser Asn Ser Gly Pro Gln Gly His Gly Glu Ile His Arg Val Pro 
    50                  55                  60                  


Thr Gln Arg Arg Pro Ser Gln Phe Asp Lys Lys Ile Leu Leu Trp Thr 
65                  70                  75                  80  


Gly Arg Phe Lys Ser Met Glu Glu Ile Pro Pro Arg Ile Pro Pro Glu 
                85                  90                  95      


Met Ile Asp Thr Ala Arg Asn Lys Ala Arg Val Lys Ala Cys Tyr Ile 
            100                 105                 110         


Met Ile Gly Leu Thr Ile Ile Ala Cys Phe Ala Val Ile Val Ser Ala 
        115                 120                 125             


Lys Arg Ala Val Glu Arg His Glu Ser Leu Thr Ser Trp Asn Leu Ala 
    130                 135                 140                 


Lys Lys Ala Lys Trp Arg Glu Glu Ala Ala Leu Ala Ala Gln Ala Lys 
145                 150                 155                 160 


Ala Lys 
        


<210>  1096
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  1096

Met Trp Arg Ser Leu Gly Leu Ala Leu Ala Leu Cys Leu Leu Pro Ser 
1               5                   10                  15      


Gly Gly Thr Glu Ser Gln Asp Gln Ser Ser Leu Cys Lys Gln Pro Pro 
            20                  25                  30          


Ala Trp Ser Ile Arg Asp Gln Asp Pro Met Leu Asn Ser Asn Gly Ser 
        35                  40                  45              


Val Thr Val Val Ala Leu Leu Gln Ala Ser Tyr Leu Cys Ile Leu Gln 
    50                  55                  60                  


Ala Ser Lys Leu Glu Asp Leu Arg Val Lys Leu Lys Lys Glu Gly Tyr 
65                  70                  75                  80  


Ser Asn Ile Ser Tyr Ile Val Val Asn His Gln Gly Ile Ser Ser Arg 
                85                  90                  95      


Leu Lys Tyr Thr His Leu Lys Asn Lys Val Ser Glu His Ile Pro Val 
            100                 105                 110         


Tyr Gln Gln Glu Glu Asn Gln Thr Asp Val Trp Thr Leu Leu Asn Gly 
        115                 120                 125             


Ser Lys Asp Asp Phe Leu Ile Tyr Asp Arg Cys Gly Arg Leu Val Tyr 
    130                 135                 140                 


His Leu Gly Leu Pro Phe Ser Phe Leu Thr Phe Pro Tyr Val Glu Glu 
145                 150                 155                 160 


Ala Ile Lys Ile Ala Tyr Cys Glu Lys Lys Cys Gly Asn Cys Ser Leu 
                165                 170                 175     


Thr Thr Leu Lys Asp Glu Asp Phe Cys Lys Arg Val Ser Leu Ala Thr 
            180                 185                 190         


Val Asp Lys Thr Val Glu Thr Pro Ser Pro His Tyr His His Glu His 
        195                 200                 205             


His His Asn His Gly His Gln His Leu Gly Ser Ser Glu Leu Ser Glu 
    210                 215                 220                 


Asn Gln Gln Pro Gly Ala Pro Asn Ala Pro Thr His Pro Ala Pro Pro 
225                 230                 235                 240 


Gly Leu His His His His Lys His Lys Gly Gln His Arg Gln Gly His 
                245                 250                 255     


Pro Glu Asn Arg Asp Met Pro Ala Ser Glu Asp Leu Gln Asp Leu Gln 
            260                 265                 270         


Lys Lys Leu Cys Arg Lys Arg Cys Ile Asn Gln Leu Leu Cys Lys Leu 
        275                 280                 285             


Pro Thr Asp Ser Glu Leu Ala Pro Arg Ser Cys Cys His Cys Arg His 
    290                 295                 300                 


Leu Ile Phe Glu Lys Thr Gly Ser Ala Ile Thr Gln Cys Lys Glu Asn 
305                 310                 315                 320 


Leu Pro Ser Leu Cys Ser Gln Gly Leu Arg Ala Glu Glu Asn Ile Thr 
                325                 330                 335     


Glu Ser Cys Gln Arg Leu Pro Pro Ala Ala Gln Ile Ser Gln Gln Leu 
            340                 345                 350         


Ile Pro Thr Glu Ala Ser Ala Ser Arg Lys Asn Gln Ala Lys Lys Glu 
        355                 360                 365             


Pro Ser Asn 
    370     


<210>  1097
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  1097

Met Trp Gly Tyr Leu Ser Leu Met Pro Val Phe Leu Ala Val Trp Ala 
1               5                   10                  15      


Ile Ser Gly Val Trp Ile Val Phe Ala Ile Ala Val Thr Asn Arg Thr 
            20                  25                  30          


Val Asp Leu Ser Lys Gly Phe Pro Tyr Ile Ser Ile Cys Gly Ser Phe 
        35                  40                  45              


Pro Pro Gln Ser Cys Ile Phe Ser Gln Val Leu Asn Met Gly Ala Ala 
    50                  55                  60                  


Leu Ala Ala Trp Ile Cys Ile Val Arg Tyr His Gln Leu Arg Asp Trp 
65                  70                  75                  80  


Gly Val Arg Arg Trp Pro Asn Gln Leu Ile Leu Trp Thr Gly Leu Leu 
                85                  90                  95      


Cys Ala Leu Gly Thr Ser Val Val Gly Asn Phe Gln Glu Lys Asn Gln 
            100                 105                 110         


Arg Pro Thr His Leu Ala Gly Ala Phe Leu Ala Phe Ile Leu Gly Asn 
        115                 120                 125             


Val Tyr Phe Trp Leu Gln Leu Leu Leu Trp Arg Leu Lys Arg Leu Pro 
    130                 135                 140                 


Gln Pro Gly Ala Ala Trp Ile Gly Pro Leu Arg Leu Gly Leu Cys Ser 
145                 150                 155                 160 


Val Cys Thr Ile Leu Ile Val Ala Met Ile Val Leu His Ala Cys Ser 
                165                 170                 175     


Leu Arg Ser Val Ser Ala Ala Cys Glu Trp Val Val Ala Met Leu Leu 
            180                 185                 190         


Phe Ala Leu Phe Gly Leu Leu Ala Val Asp Phe Ser Ala Leu Glu Ser 
        195                 200                 205             


Cys Thr Leu Cys Val Gln Pro Trp Pro Ser Leu Ser Pro Pro Pro Ala 
    210                 215                 220                 


Ser Pro Ile Ser Leu Pro Val Gln Leu 
225                 230             


<210>  1098
<211>  1704
<212>  PRT
<213>  Homo sapiens

<400>  1098

Met Ala Val Leu Arg Gln Leu Ala Leu Leu Leu Trp Lys Asn Tyr Thr 
1               5                   10                  15      


Leu Gln Lys Arg Lys Val Leu Val Thr Val Leu Glu Leu Phe Leu Pro 
            20                  25                  30          


Leu Leu Phe Ser Gly Ile Leu Ile Trp Leu Arg Leu Lys Ile Gln Ser 
        35                  40                  45              


Glu Asn Val Pro Asn Ala Thr Ile Tyr Pro Gly Gln Ser Ile Gln Glu 
    50                  55                  60                  


Leu Pro Leu Phe Phe Thr Phe Pro Pro Pro Gly Asp Thr Trp Glu Leu 
65                  70                  75                  80  


Ala Tyr Ile Pro Ser His Ser Asp Ala Ala Lys Thr Val Thr Glu Thr 
                85                  90                  95      


Val Arg Arg Ala Leu Val Ile Asn Met Arg Val Arg Gly Phe Pro Ser 
            100                 105                 110         


Glu Lys Asp Phe Glu Asp Tyr Ile Arg Tyr Asp Asn Cys Ser Ser Ser 
        115                 120                 125             


Val Leu Ala Ala Val Val Phe Glu His Pro Phe Asn His Ser Lys Glu 
    130                 135                 140                 


Pro Leu Pro Leu Ala Val Lys Tyr His Leu Arg Phe Ser Tyr Thr Arg 
145                 150                 155                 160 


Arg Asn Tyr Met Trp Thr Gln Thr Gly Ser Phe Phe Leu Lys Glu Thr 
                165                 170                 175     


Glu Gly Trp His Thr Thr Ser Leu Phe Pro Leu Phe Pro Asn Pro Gly 
            180                 185                 190         


Pro Arg Glu Pro Thr Ser Pro Asp Gly Gly Glu Pro Gly Tyr Ile Arg 
        195                 200                 205             


Glu Gly Phe Leu Ala Val Gln His Ala Val Asp Arg Ala Ile Met Glu 
    210                 215                 220                 


Tyr His Ala Asp Ala Ala Thr Arg Gln Leu Phe Gln Arg Leu Thr Val 
225                 230                 235                 240 


Thr Ile Lys Arg Phe Pro Tyr Pro Pro Phe Ile Ala Asp Pro Phe Leu 
                245                 250                 255     


Val Ala Ile Gln Tyr Gln Leu Pro Leu Leu Leu Leu Leu Ser Phe Thr 
            260                 265                 270         


Tyr Thr Ala Leu Thr Ile Ala Arg Ala Val Val Gln Glu Lys Glu Arg 
        275                 280                 285             


Arg Leu Lys Glu Tyr Met Arg Met Met Gly Leu Ser Ser Trp Leu His 
    290                 295                 300                 


Trp Ser Ala Trp Phe Leu Leu Phe Phe Leu Phe Leu Leu Ile Ala Ala 
305                 310                 315                 320 


Ser Phe Met Thr Leu Leu Phe Cys Val Lys Val Lys Pro Asn Val Ala 
                325                 330                 335     


Val Leu Ser Arg Ser Asp Pro Ser Leu Val Leu Ala Phe Leu Leu Cys 
            340                 345                 350         


Phe Ala Ile Ser Thr Ile Ser Phe Ser Phe Met Val Ser Thr Phe Phe 
        355                 360                 365             


Ser Lys Ala Asn Met Ala Ala Ala Phe Gly Gly Phe Leu Tyr Phe Phe 
    370                 375                 380                 


Thr Tyr Ile Pro Tyr Phe Phe Val Ala Pro Arg Tyr Asn Trp Met Thr 
385                 390                 395                 400 


Leu Ser Gln Lys Leu Cys Ser Cys Leu Leu Ser Asn Val Ala Met Ala 
                405                 410                 415     


Met Gly Ala Gln Leu Ile Gly Lys Phe Glu Ala Lys Gly Met Gly Ile 
            420                 425                 430         


Gln Trp Arg Asp Leu Leu Ser Pro Val Asn Val Asp Asp Asp Phe Cys 
        435                 440                 445             


Phe Gly Gln Val Leu Gly Met Leu Leu Leu Asp Ser Val Leu Tyr Gly 
    450                 455                 460                 


Leu Val Thr Trp Tyr Met Glu Ala Val Phe Pro Gly Gln Phe Gly Val 
465                 470                 475                 480 


Pro Gln Pro Trp Tyr Phe Phe Ile Met Pro Ser Tyr Trp Cys Gly Lys 
                485                 490                 495     


Pro Arg Ala Val Ala Gly Lys Glu Glu Glu Asp Ser Asp Pro Glu Lys 
            500                 505                 510         


Ala Leu Arg Asn Glu Tyr Phe Glu Ala Glu Pro Glu Asp Leu Val Ala 
        515                 520                 525             


Gly Ile Lys Ile Lys His Leu Ser Lys Val Phe Arg Val Gly Asn Lys 
    530                 535                 540                 


Asp Arg Ala Ala Val Arg Asp Leu Asn Leu Asn Leu Tyr Glu Gly Gln 
545                 550                 555                 560 


Ile Thr Val Leu Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu 
                565                 570                 575     


Ser Met Leu Thr Gly Leu Phe Pro Pro Thr Ser Gly Arg Ala Tyr Ile 
            580                 585                 590         


Ser Gly Tyr Glu Ile Ser Gln Asp Met Val Gln Ile Arg Lys Ser Leu 
        595                 600                 605             


Gly Leu Cys Pro Gln His Asp Ile Leu Phe Asp Asn Leu Thr Val Ala 
    610                 615                 620                 


Glu His Leu Tyr Phe Tyr Ala Gln Leu Lys Gly Leu Ser Arg Gln Lys 
625                 630                 635                 640 


Cys Pro Glu Glu Val Lys Gln Met Leu His Ile Ile Gly Leu Glu Asp 
                645                 650                 655     


Lys Trp Asn Ser Arg Ser Arg Phe Leu Ser Gly Gly Met Arg Arg Lys 
            660                 665                 670         


Leu Ser Ile Gly Ile Ala Leu Ile Ala Gly Ser Lys Val Leu Ile Leu 
        675                 680                 685             


Asp Glu Pro Thr Ser Gly Met Asp Ala Ile Ser Arg Arg Ala Ile Trp 
    690                 695                 700                 


Asp Leu Leu Gln Arg Gln Lys Ser Asp Arg Thr Ile Val Leu Thr Thr 
705                 710                 715                 720 


His Phe Met Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Met 
                725                 730                 735     


Ala Lys Gly Glu Leu Gln Cys Cys Gly Ser Ser Leu Phe Leu Lys Gln 
            740                 745                 750         


Lys Tyr Gly Ala Gly Tyr His Met Thr Leu Val Lys Glu Pro His Cys 
        755                 760                 765             


Asn Pro Glu Asp Ile Ser Gln Leu Val His His His Val Pro Asn Ala 
    770                 775                 780                 


Thr Leu Glu Ser Ser Ala Gly Ala Glu Leu Ser Phe Ile Leu Pro Arg 
785                 790                 795                 800 


Glu Ser Thr His Arg Phe Glu Gly Leu Phe Ala Lys Leu Glu Lys Lys 
                805                 810                 815     


Gln Lys Glu Leu Gly Ile Ala Ser Phe Gly Ala Ser Ile Thr Thr Met 
            820                 825                 830         


Glu Glu Val Phe Leu Arg Val Gly Lys Leu Val Asp Ser Ser Met Asp 
        835                 840                 845             


Ile Gln Ala Ile Gln Leu Pro Ala Leu Gln Tyr Gln His Glu Arg Arg 
    850                 855                 860                 


Ala Ser Asp Trp Ala Val Asp Ser Asn Leu Cys Gly Ala Met Asp Pro 
865                 870                 875                 880 


Ser Asp Gly Ile Gly Ala Leu Ile Glu Glu Glu Arg Thr Ala Val Lys 
                885                 890                 895     


Leu Asn Thr Gly Leu Ala Leu His Cys Gln Gln Phe Trp Ala Met Phe 
            900                 905                 910         


Leu Lys Lys Ala Ala Tyr Ser Trp Arg Glu Trp Lys Met Val Ala Ala 
        915                 920                 925             


Gln Val Leu Val Pro Leu Thr Cys Val Thr Leu Ala Leu Leu Ala Ile 
    930                 935                 940                 


Asn Tyr Ser Ser Glu Leu Phe Asp Asp Pro Met Leu Arg Leu Thr Leu 
945                 950                 955                 960 


Gly Glu Tyr Gly Arg Thr Val Val Pro Phe Ser Val Pro Gly Thr Ser 
                965                 970                 975     


Gln Leu Gly Gln Gln Leu Ser Glu His Leu Lys Asp Ala Leu Gln Ala 
            980                 985                 990         


Glu Gly Gln Glu Pro Arg Glu Val  Leu Gly Asp Leu Glu  Glu Phe Leu 
        995                 1000                 1005             


Ile Phe  Arg Ala Ser Val Glu  Gly Gly Gly Phe Asn  Glu Arg Cys 
    1010                 1015                 1020             


Leu Val  Ala Ala Ser Phe Arg  Asp Val Gly Glu Arg  Thr Val Val 
    1025                 1030                 1035             


Asn Ala  Leu Phe Asn Asn Gln  Ala Tyr His Ser Pro  Ala Thr Ala 
    1040                 1045                 1050             


Leu Ala  Val Val Asp Asn Leu  Leu Phe Lys Leu Leu  Cys Gly Pro 
    1055                 1060                 1065             


His Ala  Ser Ile Val Val Ser  Asn Phe Pro Gln Pro  Arg Ser Ala 
    1070                 1075                 1080             


Leu Gln  Ala Ala Lys Asp Gln  Phe Asn Glu Gly Arg  Lys Gly Phe 
    1085                 1090                 1095             


Asp Ile  Ala Leu Asn Leu Leu  Phe Ala Met Ala Phe  Leu Ala Ser 
    1100                 1105                 1110             


Thr Phe  Ser Ile Leu Ala Val  Ser Glu Arg Ala Val  Gln Ala Lys 
    1115                 1120                 1125             


His Val  Gln Phe Val Ser Gly  Val His Val Ala Ser  Phe Trp Leu 
    1130                 1135                 1140             


Ser Ala  Leu Leu Trp Asp Leu  Ile Ser Phe Leu Ile  Pro Ser Leu 
    1145                 1150                 1155             


Leu Leu  Leu Val Val Phe Lys  Ala Phe Asp Val Arg  Ala Phe Thr 
    1160                 1165                 1170             


Arg Asp  Gly His Met Ala Asp  Thr Leu Leu Leu Leu  Leu Leu Tyr 
    1175                 1180                 1185             


Gly Trp  Ala Ile Ile Pro Leu  Met Tyr Leu Met Asn  Phe Phe Phe 
    1190                 1195                 1200             


Leu Gly  Ala Ala Thr Ala Tyr  Thr Arg Leu Thr Ile  Phe Asn Ile 
    1205                 1210                 1215             


Leu Ser  Gly Ile Ala Thr Phe  Leu Met Val Thr Ile  Met Arg Ile 
    1220                 1225                 1230             


Pro Ala  Val Lys Leu Glu Glu  Leu Ser Lys Thr Leu  Asp His Val 
    1235                 1240                 1245             


Phe Leu  Val Leu Pro Asn His  Cys Leu Gly Met Ala  Val Ser Ser 
    1250                 1255                 1260             


Phe Tyr  Glu Asn Tyr Glu Thr  Arg Arg Tyr Cys Thr  Ser Ser Glu 
    1265                 1270                 1275             


Val Ala  Ala His Tyr Cys Lys  Lys Tyr Asn Ile Gln  Tyr Gln Glu 
    1280                 1285                 1290             


Asn Phe  Tyr Ala Trp Ser Ala  Pro Gly Val Gly Arg  Phe Val Ala 
    1295                 1300                 1305             


Ser Met  Ala Ala Ser Gly Cys  Ala Tyr Leu Ile Leu  Leu Phe Leu 
    1310                 1315                 1320             


Ile Glu  Thr Asn Leu Leu Gln  Arg Leu Arg Gly Ile  Leu Cys Ala 
    1325                 1330                 1335             


Leu Arg  Arg Arg Arg Thr Leu  Thr Glu Leu Tyr Thr  Arg Met Pro 
    1340                 1345                 1350             


Val Leu  Pro Glu Asp Gln Asp  Val Ala Asp Glu Arg  Thr Arg Ile 
    1355                 1360                 1365             


Leu Ala  Pro Ser Pro Asp Ser  Leu Leu His Thr Pro  Leu Ile Ile 
    1370                 1375                 1380             


Lys Glu  Leu Ser Lys Val Tyr  Glu Gln Arg Val Pro  Leu Leu Ala 
    1385                 1390                 1395             


Val Asp  Arg Leu Ser Leu Ala  Val Gln Lys Gly Glu  Cys Phe Gly 
    1400                 1405                 1410             


Leu Leu  Gly Phe Asn Gly Ala  Gly Lys Thr Thr Thr  Phe Lys Met 
    1415                 1420                 1425             


Leu Thr  Gly Glu Glu Ser Leu  Thr Ser Gly Asp Ala  Phe Val Gly 
    1430                 1435                 1440             


Gly His  Arg Ile Ser Ser Asp  Val Gly Lys Val Arg  Gln Arg Ile 
    1445                 1450                 1455             


Gly Tyr  Cys Pro Gln Phe Asp  Ala Leu Leu Asp His  Met Thr Gly 
    1460                 1465                 1470             


Arg Glu  Met Leu Val Met Tyr  Ala Arg Leu Arg Gly  Ile Pro Glu 
    1475                 1480                 1485             


Arg His  Ile Gly Ala Cys Val  Glu Asn Thr Leu Arg  Gly Leu Leu 
    1490                 1495                 1500             


Leu Glu  Pro His Ala Asn Lys  Leu Val Arg Thr Tyr  Ser Gly Gly 
    1505                 1510                 1515             


Asn Lys  Arg Lys Leu Ser Thr  Gly Ile Ala Leu Ile  Gly Glu Pro 
    1520                 1525                 1530             


Ala Val  Ile Phe Leu Asp Glu  Pro Ser Thr Gly Met  Asp Pro Val 
    1535                 1540                 1545             


Ala Arg  Arg Leu Leu Trp Asp  Thr Val Ala Arg Ala  Arg Glu Ser 
    1550                 1555                 1560             


Gly Lys  Ala Ile Ile Ile Thr  Ser His Ser Met Glu  Glu Cys Glu 
    1565                 1570                 1575             


Ala Leu  Cys Thr Arg Leu Ala  Ile Met Val Gln Gly  Gln Phe Lys 
    1580                 1585                 1590             


Cys Leu  Gly Ser Pro Gln His  Leu Lys Ser Lys Phe  Gly Ser Gly 
    1595                 1600                 1605             


Tyr Ser  Leu Arg Ala Lys Val  Gln Ser Glu Gly Gln  Gln Glu Ala 
    1610                 1615                 1620             


Leu Glu  Glu Phe Lys Ala Phe  Val Asp Leu Thr Phe  Pro Gly Ser 
    1625                 1630                 1635             


Val Leu  Glu Asp Glu His Gln  Gly Met Val His Tyr  His Leu Pro 
    1640                 1645                 1650             


Gly Arg  Asp Leu Ser Trp Ala  Lys Val Phe Gly Ile  Leu Glu Lys 
    1655                 1660                 1665             


Ala Lys  Glu Lys Tyr Gly Val  Asp Asp Tyr Ser Val  Ser Gln Ile 
    1670                 1675                 1680             


Ser Leu  Glu Gln Val Phe Leu  Ser Phe Ala His Leu  Gln Pro Pro 
    1685                 1690                 1695             


Thr Ala  Glu Glu Gly Arg 
    1700                 


<210>  1099
<211>  2458
<212>  PRT
<213>  Homo sapiens

<400>  1099

Met Val Leu Leu Leu Cys Leu Ser Cys Leu Ile Phe Ser Cys Leu Thr 
1               5                   10                  15      


Phe Ser Trp Leu Lys Ile Trp Gly Lys Met Thr Asp Ser Lys Pro Ile 
            20                  25                  30          


Thr Lys Ser Lys Ser Glu Ala Asn Leu Ile Pro Ser Gln Glu Pro Phe 
        35                  40                  45              


Pro Ala Ser Asp Asn Ser Gly Glu Thr Pro Gln Arg Asn Gly Glu Gly 
    50                  55                  60                  


His Thr Leu Pro Lys Thr Pro Ser Gln Ala Glu Pro Ala Ser His Lys 
65                  70                  75                  80  


Gly Pro Lys Asp Ala Gly Arg Arg Arg Asn Ser Leu Pro Pro Ser His 
                85                  90                  95      


Gln Lys Pro Pro Arg Asn Pro Leu Ser Ser Ser Asp Ala Ala Pro Ser 
            100                 105                 110         


Pro Glu Leu Gln Ala Asn Gly Thr Gly Thr Gln Gly Leu Glu Ala Thr 
        115                 120                 125             


Asp Thr Asn Gly Leu Ser Ser Ser Ala Arg Pro Gln Gly Gln Gln Ala 
    130                 135                 140                 


Gly Ser Pro Ser Lys Glu Asp Lys Lys Gln Ala Asn Ile Lys Arg Gln 
145                 150                 155                 160 


Leu Met Thr Asn Phe Ile Leu Gly Ser Phe Asp Asp Tyr Ser Ser Asp 
                165                 170                 175     


Glu Asp Ser Val Ala Gly Ser Ser Arg Glu Ser Thr Arg Lys Gly Ser 
            180                 185                 190         


Arg Ala Ser Leu Gly Ala Leu Ser Leu Glu Ala Tyr Leu Thr Thr Gly 
        195                 200                 205             


Glu Ala Glu Thr Arg Val Pro Thr Met Arg Pro Ser Met Ser Gly Leu 
    210                 215                 220                 


His Leu Val Lys Arg Gly Arg Glu His Lys Lys Leu Asp Leu His Arg 
225                 230                 235                 240 


Asp Phe Thr Val Ala Ser Pro Ala Glu Phe Val Thr Arg Phe Gly Gly 
                245                 250                 255     


Asp Arg Val Ile Glu Lys Val Leu Ile Ala Asn Asn Gly Ile Ala Ala 
            260                 265                 270         


Val Lys Cys Met Arg Ser Ile Arg Arg Trp Ala Tyr Glu Met Phe Arg 
        275                 280                 285             


Asn Glu Arg Ala Ile Arg Phe Val Val Met Val Thr Pro Glu Asp Leu 
    290                 295                 300                 


Lys Ala Asn Ala Glu Tyr Ile Lys Met Ala Asp His Tyr Val Pro Val 
305                 310                 315                 320 


Pro Gly Gly Pro Asn Asn Asn Asn Tyr Ala Asn Val Glu Leu Ile Val 
                325                 330                 335     


Asp Ile Ala Lys Arg Ile Pro Val Gln Ala Val Trp Ala Gly Trp Gly 
            340                 345                 350         


His Ala Ser Glu Asn Pro Lys Leu Pro Glu Leu Leu Cys Lys Asn Gly 
        355                 360                 365             


Val Ala Phe Leu Gly Pro Pro Ser Glu Ala Met Trp Ala Leu Gly Asp 
    370                 375                 380                 


Lys Ile Ala Ser Thr Val Val Ala Gln Thr Leu Gln Val Pro Thr Leu 
385                 390                 395                 400 


Pro Trp Ser Gly Ser Gly Leu Thr Val Glu Trp Thr Glu Asp Asp Leu 
                405                 410                 415     


Gln Gln Gly Lys Arg Ile Ser Val Pro Glu Asp Val Tyr Asp Lys Gly 
            420                 425                 430         


Cys Val Lys Asp Val Asp Glu Gly Leu Glu Ala Ala Glu Arg Ile Gly 
        435                 440                 445             


Phe Pro Leu Met Ile Lys Ala Ser Glu Gly Gly Gly Gly Lys Gly Ile 
    450                 455                 460                 


Arg Lys Ala Glu Ser Ala Glu Asp Phe Pro Ile Leu Phe Arg Gln Val 
465                 470                 475                 480 


Gln Ser Glu Ile Pro Gly Ser Pro Ile Phe Leu Met Lys Leu Ala Gln 
                485                 490                 495     


His Ala Arg His Leu Glu Val Gln Ile Leu Ala Asp Gln Tyr Gly Asn 
            500                 505                 510         


Ala Val Ser Leu Phe Gly Arg Asp Cys Ser Ile Gln Arg Arg His Gln 
        515                 520                 525             


Lys Ile Val Glu Glu Ala Pro Ala Thr Ile Ala Pro Leu Ala Ile Phe 
    530                 535                 540                 


Glu Phe Met Glu Gln Cys Ala Ile Arg Leu Ala Lys Thr Val Gly Tyr 
545                 550                 555                 560 


Val Ser Ala Gly Thr Val Glu Tyr Leu Tyr Ser Gln Asp Gly Ser Phe 
                565                 570                 575     


His Phe Leu Glu Leu Asn Pro Arg Leu Gln Val Glu His Pro Cys Thr 
            580                 585                 590         


Glu Met Ile Ala Asp Val Asn Leu Pro Ala Ala Gln Leu Gln Ile Ala 
        595                 600                 605             


Met Gly Val Pro Leu His Arg Leu Lys Asp Ile Arg Leu Leu Tyr Gly 
    610                 615                 620                 


Glu Ser Pro Trp Gly Val Thr Pro Ile Ser Phe Glu Thr Pro Ser Asn 
625                 630                 635                 640 


Pro Pro Leu Ala Arg Gly His Val Ile Ala Ala Arg Ile Thr Ser Glu 
                645                 650                 655     


Asn Pro Asp Glu Gly Phe Lys Pro Ser Ser Gly Thr Val Gln Glu Leu 
            660                 665                 670         


Asn Phe Arg Ser Ser Lys Asn Val Trp Gly Tyr Phe Ser Val Ala Ala 
        675                 680                 685             


Thr Gly Gly Leu His Glu Phe Ala Asp Ser Gln Phe Gly His Cys Phe 
    690                 695                 700                 


Ser Trp Gly Glu Asn Arg Glu Glu Ala Ile Ser Asn Met Val Val Ala 
705                 710                 715                 720 


Leu Lys Glu Leu Ser Ile Arg Gly Asp Phe Arg Thr Thr Val Glu Tyr 
                725                 730                 735     


Leu Ile Asn Leu Leu Glu Thr Glu Ser Phe Gln Asn Asn Asp Ile Asp 
            740                 745                 750         


Thr Gly Trp Leu Asp Tyr Leu Ile Ala Glu Lys Val Gln Ala Glu Lys 
        755                 760                 765             


Pro Asp Ile Met Leu Gly Val Val Cys Gly Ala Leu Asn Val Ala Asp 
    770                 775                 780                 


Ala Met Phe Arg Thr Cys Met Thr Asp Phe Leu His Ser Leu Glu Arg 
785                 790                 795                 800 


Gly Gln Val Leu Pro Ala Asp Ser Leu Leu Asn Leu Val Asp Val Glu 
                805                 810                 815     


Leu Ile Tyr Gly Gly Val Lys Tyr Ile Leu Lys Val Ala Arg Gln Ser 
            820                 825                 830         


Leu Thr Met Phe Val Leu Ile Met Asn Gly Cys His Ile Glu Ile Asp 
        835                 840                 845             


Ala His Arg Leu Asn Asp Gly Gly Leu Leu Leu Ser Tyr Asn Gly Asn 
    850                 855                 860                 


Ser Tyr Thr Thr Tyr Met Lys Glu Glu Val Asp Ser Tyr Arg Ile Thr 
865                 870                 875                 880 


Ile Gly Asn Lys Thr Cys Val Phe Glu Lys Glu Asn Asp Pro Thr Val 
                885                 890                 895     


Leu Arg Ser Pro Ser Ala Gly Lys Leu Thr Gln Tyr Thr Val Glu Asp 
            900                 905                 910         


Gly Gly His Val Glu Ala Gly Ser Ser Tyr Ala Glu Met Glu Val Met 
        915                 920                 925             


Lys Met Ile Met Thr Leu Asn Val Gln Glu Arg Gly Arg Val Lys Tyr 
    930                 935                 940                 


Ile Lys Arg Pro Gly Ala Val Leu Glu Ala Gly Cys Val Val Ala Arg 
945                 950                 955                 960 


Leu Glu Leu Asp Asp Pro Ser Lys Val His Pro Ala Glu Pro Phe Thr 
                965                 970                 975     


Gly Glu Leu Pro Ala Gln Gln Thr Leu Pro Ile Leu Gly Glu Lys Leu 
            980                 985                 990         


His Gln Val Phe His Ser Val Leu  Glu Asn Leu Thr Asn  Val Met Ser 
        995                 1000                 1005             


Gly Phe  Cys Leu Pro Glu Pro  Val Phe Ser Ile Lys  Leu Lys Glu 
    1010                 1015                 1020             


Trp Val  Gln Lys Leu Met Met  Thr Leu Arg His Pro  Ser Leu Pro 
    1025                 1030                 1035             


Leu Leu  Glu Leu Gln Glu Ile  Met Thr Ser Val Ala  Gly Arg Ile 
    1040                 1045                 1050             


Pro Ala  Pro Val Glu Lys Ser  Val Arg Arg Val Met  Ala Gln Tyr 
    1055                 1060                 1065             


Ala Ser  Asn Ile Thr Ser Val  Leu Cys Gln Phe Pro  Ser Gln Gln 
    1070                 1075                 1080             


Ile Ala  Thr Ile Leu Asp Cys  His Ala Ala Thr Leu  Gln Arg Lys 
    1085                 1090                 1095             


Ala Asp  Arg Glu Val Phe Phe  Ile Asn Thr Gln Ser  Ile Val Gln 
    1100                 1105                 1110             


Leu Val  Gln Arg Tyr Arg Ser  Gly Ile Arg Gly Tyr  Met Lys Thr 
    1115                 1120                 1125             


Val Val  Leu Asp Leu Leu Arg  Arg Tyr Leu Arg Val  Glu His His 
    1130                 1135                 1140             


Phe Gln  Gln Ala His Tyr Asp  Lys Cys Val Ile Asn  Leu Arg Glu 
    1145                 1150                 1155             


Gln Phe  Lys Pro Asp Met Ser  Gln Val Leu Asp Cys  Ile Phe Ser 
    1160                 1165                 1170             


His Ala  Gln Val Ala Lys Lys  Asn Gln Leu Val Ile  Met Leu Ile 
    1175                 1180                 1185             


Asp Glu  Leu Cys Gly Pro Asp  Pro Ser Leu Ser Asp  Glu Leu Ile 
    1190                 1195                 1200             


Ser Ile  Leu Asn Glu Leu Thr  Gln Leu Ser Lys Ser  Glu His Cys 
    1205                 1210                 1215             


Lys Val  Ala Leu Arg Ala Arg  Gln Ile Leu Ile Ala  Ser His Leu 
    1220                 1225                 1230             


Pro Ser  Tyr Glu Leu Arg His  Asn Gln Val Glu Ser  Ile Phe Leu 
    1235                 1240                 1245             


Ser Ala  Ile Asp Met Tyr Gly  His Gln Phe Cys Pro  Glu Asn Leu 
    1250                 1255                 1260             


Lys Lys  Leu Ile Leu Ser Glu  Thr Thr Ile Phe Asp  Val Leu Pro 
    1265                 1270                 1275             


Thr Phe  Phe Tyr His Ala Asn  Lys Val Val Cys Met  Ala Ser Leu 
    1280                 1285                 1290             


Glu Val  Tyr Val Arg Arg Gly  Tyr Ile Ala Tyr Glu  Leu Asn Ser 
    1295                 1300                 1305             


Leu Gln  His Arg Gln Leu Pro  Asp Gly Thr Cys Val  Val Glu Phe 
    1310                 1315                 1320             


Gln Phe  Met Leu Pro Ser Ser  His Pro Asn Arg Met  Thr Val Pro 
    1325                 1330                 1335             


Ile Ser  Ile Thr Asn Pro Asp  Leu Leu Arg His Ser  Thr Glu Leu 
    1340                 1345                 1350             


Phe Met  Asp Ser Gly Phe Ser  Pro Leu Cys Gln Arg  Met Gly Ala 
    1355                 1360                 1365             


Met Val  Ala Phe Arg Arg Phe  Glu Asp Phe Thr Arg  Asn Phe Asp 
    1370                 1375                 1380             


Glu Val  Ile Ser Cys Phe Ala  Asn Val Pro Lys Asp  Thr Pro Leu 
    1385                 1390                 1395             


Phe Ser  Glu Ala Arg Thr Ser  Leu Tyr Ser Glu Asp  Asp Cys Lys 
    1400                 1405                 1410             


Ser Leu  Arg Glu Glu Pro Ile  His Ile Leu Asn Val  Ser Ile Gln 
    1415                 1420                 1425             


Cys Ala  Asp His Leu Glu Asp  Glu Ala Leu Val Pro  Ile Leu Arg 
    1430                 1435                 1440             


Thr Phe  Val Gln Ser Lys Lys  Asn Ile Leu Val Asp  Tyr Gly Leu 
    1445                 1450                 1455             


Arg Arg  Ile Thr Phe Leu Ile  Ala Gln Glu Lys Glu  Phe Pro Lys 
    1460                 1465                 1470             


Phe Phe  Thr Phe Arg Ala Arg  Asp Glu Phe Ala Glu  Asp Arg Ile 
    1475                 1480                 1485             


Tyr Arg  His Leu Glu Pro Ala  Leu Ala Phe Gln Leu  Glu Leu Asn 
    1490                 1495                 1500             


Arg Met  Arg Asn Phe Asp Leu  Thr Ala Val Pro Cys  Ala Asn His 
    1505                 1510                 1515             


Lys Met  His Leu Tyr Leu Gly  Ala Ala Lys Val Lys  Glu Gly Val 
    1520                 1525                 1530             


Glu Val  Thr Asp His Arg Phe  Phe Ile Arg Ala Ile  Ile Arg His 
    1535                 1540                 1545             


Ser Asp  Leu Ile Thr Lys Glu  Ala Ser Phe Glu Tyr  Leu Gln Asn 
    1550                 1555                 1560             


Glu Gly  Glu Arg Leu Leu Leu  Glu Ala Met Asp Glu  Leu Glu Val 
    1565                 1570                 1575             


Ala Phe  Asn Asn Thr Ser Val  Arg Thr Asp Cys Asn  His Ile Phe 
    1580                 1585                 1590             


Leu Asn  Phe Val Pro Thr Val  Ile Met Asp Pro Phe  Lys Ile Glu 
    1595                 1600                 1605             


Glu Ser  Val Arg Tyr Met Val  Met Arg Tyr Gly Ser  Arg Leu Trp 
    1610                 1615                 1620             


Lys Leu  Arg Val Leu Gln Ala  Glu Val Lys Ile Asn  Ile Arg Gln 
    1625                 1630                 1635             


Thr Thr  Thr Gly Ser Ala Val  Pro Ile Arg Leu Phe  Ile Thr Asn 
    1640                 1645                 1650             


Glu Ser  Gly Tyr Tyr Leu Asp  Ile Ser Leu Tyr Lys  Glu Val Thr 
    1655                 1660                 1665             


Asp Ser  Arg Ser Gly Asn Ile  Met Phe His Ser Phe  Gly Asn Lys 
    1670                 1675                 1680             


Gln Gly  Pro Gln His Gly Met  Leu Ile Asn Thr Pro  Tyr Val Thr 
    1685                 1690                 1695             


Lys Asp  Leu Leu Gln Ala Lys  Arg Phe Gln Ala Gln  Thr Leu Gly 
    1700                 1705                 1710             


Thr Thr  Tyr Ile Tyr Asp Phe  Pro Glu Met Phe Arg  Gln Ala Leu 
    1715                 1720                 1725             


Phe Lys  Leu Trp Gly Ser Pro  Asp Lys Tyr Pro Lys  Asp Ile Leu 
    1730                 1735                 1740             


Thr Tyr  Thr Glu Leu Val Leu  Asp Ser Gln Gly Gln  Leu Val Glu 
    1745                 1750                 1755             


Met Asn  Arg Leu Pro Gly Gly  Asn Glu Val Gly Met  Val Ala Phe 
    1760                 1765                 1770             


Lys Met  Arg Phe Lys Thr Gln  Glu Tyr Pro Glu Gly  Arg Asp Val 
    1775                 1780                 1785             


Ile Val  Ile Gly Asn Asp Ile  Thr Phe Arg Ile Gly  Ser Phe Gly 
    1790                 1795                 1800             


Pro Gly  Glu Asp Leu Leu Tyr  Leu Arg Ala Ser Glu  Met Ala Arg 
    1805                 1810                 1815             


Ala Glu  Gly Ile Pro Lys Ile  Tyr Val Ala Ala Asn  Ser Gly Ala 
    1820                 1825                 1830             


Arg Ile  Gly Met Ala Glu Glu  Ile Lys His Met Phe  His Val Ala 
    1835                 1840                 1845             


Trp Val  Asp Pro Glu Asp Pro  His Lys Gly Phe Lys  Tyr Leu Tyr 
    1850                 1855                 1860             


Leu Thr  Pro Gln Asp Tyr Thr  Arg Ile Ser Ser Leu  Asn Ser Val 
    1865                 1870                 1875             


His Cys  Lys His Ile Glu Glu  Gly Gly Glu Ser Arg  Tyr Met Ile 
    1880                 1885                 1890             


Thr Asp  Ile Ile Gly Lys Asp  Asp Gly Leu Gly Val  Glu Asn Leu 
    1895                 1900                 1905             


Arg Gly  Ser Gly Met Ile Ala  Gly Glu Ser Ser Leu  Ala Tyr Glu 
    1910                 1915                 1920             


Glu Ile  Val Thr Ile Ser Leu  Val Thr Cys Arg Ala  Ile Gly Ile 
    1925                 1930                 1935             


Gly Ala  Tyr Leu Val Arg Leu  Gly Gln Arg Val Ile  Gln Val Glu 
    1940                 1945                 1950             


Asn Ser  His Ile Ile Leu Thr  Gly Ala Ser Ala Leu  Asn Lys Val 
    1955                 1960                 1965             


Leu Gly  Arg Glu Val Tyr Thr  Ser Asn Asn Gln Leu  Gly Gly Val 
    1970                 1975                 1980             


Gln Ile  Met His Tyr Asn Gly  Val Ser His Ile Thr  Val Pro Asp 
    1985                 1990                 1995             


Asp Phe  Glu Gly Val Tyr Thr  Ile Leu Glu Trp Leu  Ser Tyr Met 
    2000                 2005                 2010             


Pro Lys  Asp Asn His Ser Pro  Val Pro Ile Ile Thr  Pro Thr Asp 
    2015                 2020                 2025             


Pro Ile  Asp Arg Glu Ile Glu  Phe Leu Pro Ser Arg  Ala Pro Tyr 
    2030                 2035                 2040             


Asp Pro  Arg Trp Met Leu Ala  Gly Arg Pro His Pro  Thr Leu Lys 
    2045                 2050                 2055             


Gly Thr  Trp Gln Ser Gly Phe  Phe Asp His Gly Ser  Phe Lys Glu 
    2060                 2065                 2070             


Ile Met  Ala Pro Trp Ala Gln  Thr Val Val Thr Gly  Arg Ala Arg 
    2075                 2080                 2085             


Leu Gly  Gly Ile Pro Val Gly  Val Ile Ala Val Glu  Thr Arg Thr 
    2090                 2095                 2100             


Val Glu  Val Ala Val Pro Ala  Asp Pro Ala Asn Leu  Asp Ser Glu 
    2105                 2110                 2115             


Ala Lys  Ile Ile Gln Gln Ala  Gly Gln Val Trp Phe  Pro Asp Ser 
    2120                 2125                 2130             


Ala Tyr  Lys Thr Ala Gln Ala  Val Lys Asp Phe Asn  Arg Glu Lys 
    2135                 2140                 2145             


Leu Pro  Leu Met Ile Phe Ala  Asn Trp Arg Gly Phe  Ser Gly Gly 
    2150                 2155                 2160             


Met Lys  Asp Met Tyr Asp Gln  Val Leu Lys Phe Gly  Ala Tyr Ile 
    2165                 2170                 2175             


Val Asp  Gly Leu Arg Gln Tyr  Lys Gln Pro Ile Leu  Ile Tyr Ile 
    2180                 2185                 2190             


Pro Pro  Tyr Ala Glu Leu Arg  Gly Gly Ser Trp Val  Val Ile Asp 
    2195                 2200                 2205             


Ala Thr  Ile Asn Pro Leu Cys  Ile Glu Met Tyr Ala  Asp Lys Glu 
    2210                 2215                 2220             


Ser Arg  Gly Gly Val Leu Glu  Pro Glu Gly Thr Val  Glu Ile Lys 
    2225                 2230                 2235             


Phe Arg  Lys Lys Asp Leu Ile  Lys Ser Met Arg Arg  Ile Asp Pro 
    2240                 2245                 2250             


Ala Tyr  Lys Lys Leu Met Glu  Gln Leu Gly Glu Pro  Asp Leu Ser 
    2255                 2260                 2265             


Asp Lys  Asp Arg Lys Asp Leu  Glu Gly Arg Leu Lys  Ala Arg Glu 
    2270                 2275                 2280             


Asp Leu  Leu Leu Pro Ile Tyr  His Gln Val Ala Val  Gln Phe Ala 
    2285                 2290                 2295             


Asp Phe  His Asp Thr Pro Gly  Arg Met Leu Glu Lys  Gly Val Ile 
    2300                 2305                 2310             


Ser Asp  Ile Leu Glu Trp Lys  Thr Ala Arg Thr Phe  Leu Tyr Trp 
    2315                 2320                 2325             


Arg Leu  Arg Arg Leu Leu Leu  Glu Asp Gln Val Lys  Gln Glu Ile 
    2330                 2335                 2340             


Leu Gln  Ala Ser Gly Glu Leu  Ser His Val His Ile  Gln Ser Met 
    2345                 2350                 2355             


Leu Arg  Arg Trp Phe Val Glu  Thr Glu Gly Ala Val  Lys Ala Tyr 
    2360                 2365                 2370             


Leu Trp  Asp Asn Asn Gln Val  Val Val Gln Trp Leu  Glu Gln His 
    2375                 2380                 2385             


Trp Gln  Ala Gly Asp Gly Pro  Arg Ser Thr Ile Arg  Glu Asn Ile 
    2390                 2395                 2400             


Thr Tyr  Leu Lys His Asp Ser  Val Leu Lys Thr Ile  Arg Gly Leu 
    2405                 2410                 2415             


Val Glu  Glu Asn Pro Glu Val  Ala Val Asp Cys Val  Ile Tyr Leu 
    2420                 2425                 2430             


Ser Gln  His Ile Ser Pro Ala  Glu Arg Ala Gln Val  Val His Leu 
    2435                 2440                 2445             


Leu Ser  Thr Met Asp Ser Pro  Ala Ser Thr 
    2450                 2455             


<210>  1100
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  1100

Met Cys Ser Gly Leu Asp Ala Val Ala His Ala Cys Asn Pro Ser Thr 
1               5                   10                  15      


Leu Gly Gly Gln Gly Arg Arg Ile Thr Arg Thr Thr Pro Ala Met Trp 
            20                  25                  30          


Arg Ser Leu Gly Leu Ala Leu Ala Leu Cys Leu Leu Pro Ser Gly Gly 
        35                  40                  45              


Thr Glu Ser Gln Asp Gln Ser Ser Leu Cys Lys Gln Pro Pro Ala Trp 
    50                  55                  60                  


Ser Ile Arg Asp Gln Asp Pro Met Leu Asn Ser Asn Gly Ser Val Thr 
65                  70                  75                  80  


Val Val Ala Leu Leu Gln Ala Ser Tyr Leu Cys Ile Leu Gln Ala Ser 
                85                  90                  95      


Lys Leu Glu Asp Leu Arg Val Lys Leu Lys Lys Glu Gly Tyr Ser Asn 
            100                 105                 110         


Ile Ser Tyr Ile Val Val Asn His Gln Gly Ile Ser Ser Arg Leu Lys 
        115                 120                 125             


Tyr Thr His Leu Lys Asn Lys Val Ser Glu His Ile Pro Val Tyr Gln 
    130                 135                 140                 


Gln Glu Glu Asn Gln Thr Asp Val Trp Thr Leu Leu Asn Gly Ser Lys 
145                 150                 155                 160 


Asp Asp Phe Leu Ile Tyr Asp Arg Cys Gly Arg Leu Val Tyr His Leu 
                165                 170                 175     


Gly Leu Pro Phe Ser Phe Leu Thr Phe Pro Tyr Val Glu Glu Ala Ile 
            180                 185                 190         


Lys Ile Ala Tyr Cys Glu Lys Lys Cys Gly Asn Cys Ser Leu Thr Thr 
        195                 200                 205             


Leu Lys Asp Glu Asp Phe Cys Lys Arg Val Ser Leu Ala Thr Val Asp 
    210                 215                 220                 


Lys Thr Val Glu Thr Pro Ser Pro His Tyr His His Glu His His His 
225                 230                 235                 240 


Asn His Gly His Gln His Leu Gly Ser Ser Glu Leu Ser Glu Asn Gln 
                245                 250                 255     


Gln Pro Gly Ala Pro Asn Ala Pro Thr His Pro Ala Pro Pro Gly Leu 
            260                 265                 270         


His His His His Lys His Lys Gly Gln His Arg Gln Gly His Pro Glu 
        275                 280                 285             


Asn Arg Asp Met Pro Ala Ser Glu Asp Leu Gln Asp Leu Gln Lys Lys 
    290                 295                 300                 


Leu Cys Arg Lys Arg Cys Ile Asn Gln Leu Leu Cys Lys Leu Pro Thr 
305                 310                 315                 320 


Asp Ser Glu Leu Ala Pro Arg Ser Cys Cys His Cys Arg His Leu Ile 
                325                 330                 335     


Phe Glu Lys Thr Gly Ser Ala Ile Thr Gln Cys Lys Glu Asn Leu Pro 
            340                 345                 350         


Ser Leu Cys Ser Gln Gly Leu Arg Ala Glu Glu Asn Ile Thr Glu Ser 
        355                 360                 365             


Cys Gln Arg Leu Pro Pro Ala Ala Gln Ile Ser Gln Gln Leu Ile Pro 
    370                 375                 380                 


Thr Glu Ala Ser Ala Ser Arg Lys Asn Gln Ala Lys Lys Glu Pro Ser 
385                 390                 395                 400 


Asn 
    


<210>  1101
<211>  972
<212>  PRT
<213>  Homo sapiens

<400>  1101

Met Arg Gly Ala Arg Gly Ala Trp Asp Phe Leu Cys Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Arg Val Gln Thr Gly Ser Ser Gln Pro Ser Val Ser Pro Gly 
            20                  25                  30          


Glu Pro Ser Pro Pro Ser Ile His Pro Gly Lys Ser Asp Leu Ile Val 
        35                  40                  45              


Arg Val Gly Asp Glu Ile Arg Leu Leu Cys Thr Asp Pro Gly Phe Val 
    50                  55                  60                  


Lys Trp Thr Phe Glu Ile Leu Asp Glu Thr Asn Glu Asn Lys Gln Asn 
65                  70                  75                  80  


Glu Trp Ile Thr Glu Lys Ala Glu Ala Thr Asn Thr Gly Lys Tyr Thr 
                85                  90                  95      


Cys Thr Asn Lys His Gly Leu Ser Asn Ser Ile Tyr Val Phe Val Arg 
            100                 105                 110         


Asp Pro Ala Lys Leu Phe Leu Val Asp Arg Ser Leu Tyr Gly Lys Glu 
        115                 120                 125             


Asp Asn Asp Thr Leu Val Arg Cys Pro Leu Thr Asp Pro Glu Val Thr 
    130                 135                 140                 


Asn Tyr Ser Leu Lys Gly Cys Gln Gly Lys Pro Leu Pro Lys Asp Leu 
145                 150                 155                 160 


Arg Phe Ile Pro Asp Pro Lys Ala Gly Ile Met Ile Lys Ser Val Lys 
                165                 170                 175     


Arg Ala Tyr His Arg Leu Cys Leu His Cys Ser Val Asp Gln Glu Gly 
            180                 185                 190         


Lys Ser Val Leu Ser Glu Lys Phe Ile Leu Lys Val Arg Pro Ala Phe 
        195                 200                 205             


Lys Ala Val Pro Val Val Ser Val Ser Lys Ala Ser Tyr Leu Leu Arg 
    210                 215                 220                 


Glu Gly Glu Glu Phe Thr Val Thr Cys Thr Ile Lys Asp Val Ser Ser 
225                 230                 235                 240 


Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn Ser Gln Thr Lys Leu Gln 
                245                 250                 255     


Glu Lys Tyr Asn Ser Trp His His Gly Asp Phe Asn Tyr Glu Arg Gln 
            260                 265                 270         


Ala Thr Leu Thr Ile Ser Ser Ala Arg Val Asn Asp Ser Gly Val Phe 
        275                 280                 285             


Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn Val Thr Thr Thr 
    290                 295                 300                 


Leu Glu Val Val Asp Lys Gly Phe Ile Asn Ile Phe Pro Met Ile Asn 
305                 310                 315                 320 


Thr Thr Val Phe Val Asn Asp Gly Glu Asn Val Asp Leu Ile Val Glu 
                325                 330                 335     


Tyr Glu Ala Phe Pro Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn 
            340                 345                 350         


Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu 
        355                 360                 365             


Ser Asn Ile Arg Tyr Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly 
    370                 375                 380                 


Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp Val Asn 
385                 390                 395                 400 


Ala Ala Ile Ala Phe Asn Val Tyr Val Asn Thr Lys Pro Glu Ile Leu 
                405                 410                 415     


Thr Tyr Asp Arg Leu Val Asn Gly Met Leu Gln Cys Val Ala Ala Gly 
            420                 425                 430         


Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe Cys Pro Gly Thr Glu Gln 
        435                 440                 445             


Arg Cys Ser Ala Ser Val Leu Pro Val Asp Val Gln Thr Leu Asn Ser 
    450                 455                 460                 


Ser Gly Pro Pro Phe Gly Lys Leu Val Val Gln Ser Ser Ile Asp Ser 
465                 470                 475                 480 


Ser Ala Phe Lys His Asn Gly Thr Val Glu Cys Lys Ala Tyr Asn Asp 
                485                 490                 495     


Val Gly Lys Thr Ser Ala Tyr Phe Asn Phe Ala Phe Lys Glu Gln Ile 
            500                 505                 510         


His Pro His Thr Leu Phe Thr Pro Leu Leu Ile Gly Phe Val Ile Val 
        515                 520                 525             


Ala Gly Met Met Cys Ile Ile Val Met Ile Leu Thr Tyr Lys Tyr Leu 
    530                 535                 540                 


Gln Lys Pro Met Tyr Glu Val Gln Trp Lys Val Val Glu Glu Ile Asn 
545                 550                 555                 560 


Gly Asn Asn Tyr Val Tyr Ile Asp Pro Thr Gln Leu Pro Tyr Asp His 
                565                 570                 575     


Lys Trp Glu Phe Pro Arg Asn Arg Leu Ser Phe Gly Lys Thr Leu Gly 
            580                 585                 590         


Ala Gly Ala Phe Gly Lys Val Val Glu Ala Thr Ala Tyr Gly Leu Ile 
        595                 600                 605             


Lys Ser Asp Ala Ala Met Thr Val Ala Val Lys Met Leu Lys Pro Ser 
    610                 615                 620                 


Ala His Leu Thr Glu Arg Glu Ala Leu Met Ser Glu Leu Lys Val Leu 
625                 630                 635                 640 


Ser Tyr Leu Gly Asn His Met Asn Ile Val Asn Leu Leu Gly Ala Cys 
                645                 650                 655     


Thr Ile Gly Gly Pro Thr Leu Val Ile Thr Glu Tyr Cys Cys Tyr Gly 
            660                 665                 670         


Asp Leu Leu Asn Phe Leu Arg Arg Lys Arg Asp Ser Phe Ile Cys Ser 
        675                 680                 685             


Lys Gln Glu Asp His Ala Glu Ala Ala Leu Tyr Lys Asn Leu Leu His 
    690                 695                 700                 


Ser Lys Glu Ser Ser Cys Ser Asp Ser Thr Asn Glu Tyr Met Asp Met 
705                 710                 715                 720 


Lys Pro Gly Val Ser Tyr Val Val Pro Thr Lys Ala Asp Lys Arg Arg 
                725                 730                 735     


Ser Val Arg Ile Gly Ser Tyr Ile Glu Arg Asp Val Thr Pro Ala Ile 
            740                 745                 750         


Met Glu Asp Asp Glu Leu Ala Leu Asp Leu Glu Asp Leu Leu Ser Phe 
        755                 760                 765             


Ser Tyr Gln Val Ala Lys Gly Met Ala Phe Leu Ala Ser Lys Asn Cys 
    770                 775                 780                 


Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu Thr His Gly Arg 
785                 790                 795                 800 


Ile Thr Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile Lys Asn Asp 
                805                 810                 815     


Ser Asn Tyr Val Val Lys Gly Asn Ala Arg Leu Pro Val Lys Trp Met 
            820                 825                 830         


Ala Pro Glu Ser Ile Phe Asn Cys Val Tyr Thr Phe Glu Ser Asp Val 
        835                 840                 845             


Trp Ser Tyr Gly Ile Phe Leu Trp Glu Leu Phe Ser Leu Gly Ser Ser 
    850                 855                 860                 


Pro Tyr Pro Gly Met Pro Val Asp Ser Lys Phe Tyr Lys Met Ile Lys 
865                 870                 875                 880 


Glu Gly Phe Arg Met Leu Ser Pro Glu His Ala Pro Ala Glu Met Tyr 
                885                 890                 895     


Asp Ile Met Lys Thr Cys Trp Asp Ala Asp Pro Leu Lys Arg Pro Thr 
            900                 905                 910         


Phe Lys Gln Ile Val Gln Leu Ile Glu Lys Gln Ile Ser Glu Ser Thr 
        915                 920                 925             


Asn His Ile Tyr Ser Asn Leu Ala Asn Cys Ser Pro Asn Arg Gln Lys 
    930                 935                 940                 


Pro Val Val Asp His Ser Val Arg Ile Asn Ser Val Gly Ser Thr Ala 
945                 950                 955                 960 


Ser Ser Ser Gln Pro Leu Leu Val His Asp Asp Val 
                965                 970         


<210>  1102
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  1102

Met Arg Ala Ala Pro Leu Leu Leu Ala Arg Ala Ala Ser Leu Ser Leu 
1               5                   10                  15      


Gly Phe Leu Phe Leu Leu Phe Phe Trp Leu Asp Arg Ser Val Leu Ala 
            20                  25                  30          


Lys Glu Leu Lys Phe Val Thr Leu Val Phe Arg His Gly Asp Arg Ser 
        35                  40                  45              


Pro Ile Asp Thr Phe Pro Thr Asp Pro Ile Lys Glu Ser Ser Trp Pro 
    50                  55                  60                  


Gln Gly Phe Gly Gln Leu Thr Gln Leu Gly Met Glu Gln His Tyr Glu 
65                  70                  75                  80  


Leu Gly Glu Tyr Ile Arg Lys Arg Tyr Arg Lys Phe Leu Asn Glu Ser 
                85                  90                  95      


Tyr Lys His Glu Gln Val Tyr Ile Arg Ser Thr Asp Val Asp Arg Thr 
            100                 105                 110         


Leu Met Ser Ala Met Thr Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly 
        115                 120                 125             


Val Ser Ile Trp Asn Pro Ile Leu Leu Trp Gln Pro Ile Pro Val His 
    130                 135                 140                 


Thr Val Pro Leu Ser Glu Asp Gln Leu Leu Tyr Leu Pro Phe Arg Asn 
145                 150                 155                 160 


Cys Pro Arg Phe Gln Glu Leu Glu Ser Glu Thr Leu Lys Ser Glu Glu 
                165                 170                 175     


Phe Gln Lys Arg Leu His Pro Tyr Lys Asp Phe Ile Ala Thr Leu Gly 
            180                 185                 190         


Lys Leu Ser Gly Leu His Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys 
        195                 200                 205             


Val Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Thr Leu Pro 
    210                 215                 220                 


Ser Trp Ala Thr Glu Asp Thr Met Thr Lys Leu Arg Glu Leu Ser Glu 
225                 230                 235                 240 


Leu Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser 
                245                 250                 255     


Arg Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Asn His Met Lys 
            260                 265                 270         


Arg Ala Thr Gln Ile Pro Ser Tyr Lys Lys Leu Ile Met Tyr Ser Ala 
        275                 280                 285             


His Asp Thr Thr Val Ser Gly Leu Gln Met Ala Leu Asp Val Tyr Asn 
    290                 295                 300                 


Gly Leu Leu Pro Pro Tyr Ala Ser Cys His Leu Thr Glu Leu Tyr Phe 
305                 310                 315                 320 


Glu Lys Gly Glu Tyr Phe Val Glu Met Tyr Tyr Arg Asn Glu Thr Gln 
                325                 330                 335     


His Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys Ser Pro Ser Cys Pro 
            340                 345                 350         


Leu Glu Arg Phe Ala Glu Leu Val Gly Pro Val Ile Pro Gln Asp Trp 
        355                 360                 365             


Ser Thr Glu Cys Met Thr Thr Asn Ser His Gln Gly Thr Glu Asp Ser 
    370                 375                 380                 


Thr Asp 
385     


<210>  1103
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  1103

Met Val Met Gly Leu Gly Val Leu Leu Leu Val Phe Val Leu Gly Leu 
1               5                   10                  15      


Gly Leu Thr Pro Pro Thr Leu Ala Gln Asp Asn Ser Arg Tyr Thr His 
            20                  25                  30          


Phe Leu Thr Gln His Tyr Asp Ala Lys Pro Gln Gly Arg Asp Asp Arg 
        35                  40                  45              


Tyr Cys Glu Ser Ile Met Arg Arg Arg Gly Leu Thr Ser Pro Cys Lys 
    50                  55                  60                  


Asp Ile Asn Thr Phe Ile His Gly Asn Lys Arg Ser Ile Lys Ala Ile 
65                  70                  75                  80  


Cys Glu Asn Lys Asn Gly Asn Pro His Arg Glu Asn Leu Arg Ile Ser 
                85                  90                  95      


Lys Ser Ser Phe Gln Val Thr Thr Cys Lys Leu His Gly Gly Ser Pro 
            100                 105                 110         


Trp Pro Pro Cys Gln Tyr Arg Ala Thr Ala Gly Phe Arg Asn Val Val 
        115                 120                 125             


Val Ala Cys Glu Asn Gly Leu Pro Val His Leu Asp Gln Ser Ile Phe 
    130                 135                 140                 


Arg Arg Pro 
145         


<210>  1104
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  1104

Met Arg Ser His Thr Ile Thr Met Thr Thr Thr Ser Val Ser Ser Trp 
1               5                   10                  15      


Pro Tyr Ser Ser His Arg Met Arg Phe Ile Thr Asn His Ser Asp Gln 
            20                  25                  30          


Pro Pro Gln Asn Phe Ser Ala Thr Pro Asn Val Thr Thr Cys Pro Met 
        35                  40                  45              


Asp Glu Lys Leu Leu Ser Thr Val Leu Thr Thr Ser Tyr Ser Val Ile 
    50                  55                  60                  


Phe Ile Val Gly Leu Val Gly Asn Ile Ile Ala Leu Tyr Val Phe Leu 
65                  70                  75                  80  


Gly Ile His Arg Lys Arg Asn Ser Ile Gln Ile Tyr Leu Leu Asn Val 
                85                  90                  95      


Ala Ile Ala Asp Leu Leu Leu Ile Phe Cys Leu Pro Phe Arg Ile Met 
            100                 105                 110         


Tyr His Ile Asn Gln Asn Lys Trp Thr Leu Gly Val Ile Leu Cys Lys 
        115                 120                 125             


Val Val Gly Thr Leu Phe Tyr Met Asn Met Tyr Ile Ser Ile Ile Leu 
    130                 135                 140                 


Leu Gly Phe Ile Ser Leu Asp Arg Tyr Ile Lys Ile Asn Arg Ser Ile 
145                 150                 155                 160 


Gln Gln Arg Lys Ala Ile Thr Thr Lys Gln Ser Ile Tyr Val Cys Cys 
                165                 170                 175     


Ile Val Trp Met Leu Ala Leu Gly Gly Phe Leu Thr Met Ile Ile Leu 
            180                 185                 190         


Thr Leu Lys Lys Gly Gly His Asn Ser Thr Met Cys Phe His Tyr Arg 
        195                 200                 205             


Asp Lys His Asn Ala Lys Gly Glu Ala Ile Phe Asn Phe Ile Leu Val 
    210                 215                 220                 


Val Met Phe Trp Leu Ile Phe Leu Leu Ile Ile Leu Ser Tyr Ile Lys 
225                 230                 235                 240 


Ile Gly Lys Asn Leu Leu Arg Ile Ser Lys Arg Arg Ser Lys Phe Pro 
                245                 250                 255     


Asn Ser Gly Lys Tyr Ala Thr Thr Ala Arg Asn Ser Phe Ile Val Leu 
            260                 265                 270         


Ile Ile Phe Thr Ile Cys Phe Val Pro Tyr His Ala Phe Arg Phe Ile 
        275                 280                 285             


Tyr Ile Ser Ser Gln Leu Asn Val Ser Ser Cys Tyr Trp Lys Glu Ile 
    290                 295                 300                 


Val His Lys Thr Asn Glu Ile Met Leu Val Leu Ser Ser Phe Asn Ser 
305                 310                 315                 320 


Cys Leu Asp Pro Val Met Tyr Phe Leu Met Ser Ser Asn Ile Arg Lys 
                325                 330                 335     


Ile Met Cys Gln Leu Leu Phe Arg Arg Phe Gln Gly Glu Pro Ser Arg 
            340                 345                 350         


Ser Glu Ser Thr Ser Glu Phe Lys Pro Gly Tyr Ser Leu His Asp Thr 
        355                 360                 365             


Ser Val Ala Val Lys Ile Gln Ser Ser Ser Lys Ser Thr 
    370                 375                 380     


<210>  1105
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  1105

Met Asp Ile Pro Ile Ser Ser Arg Asp Phe Arg Gly Leu Gln Leu Ala 
1               5                   10                  15      


Cys Val Ala Leu Gly Leu Val Ala Gly Ser Ile Ile Ile Gly Ile Ser 
            20                  25                  30          


Val Ser Lys Ala Ala Ala Ala Met Gly Gly Val Phe Ile Gly Ala Ala 
        35                  40                  45              


Val Leu Gly Ser Leu Arg Ile His Pro His Pro Gly Ala Asp His Gly 
    50                  55                  60                  


Glu Gly Arg Ser Ser Thr Asn Gly Asn Lys Glu Gly Ala Arg Ser Ser 
65                  70                  75                  80  


Leu Ser Thr Val Ser Arg Thr Leu Glu Lys Leu Lys Pro Gly Thr Arg 
                85                  90                  95      


Gly Ala Glu Glu Cys 
            100     


<210>  1106
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  1106

Met Leu Arg Thr Leu Leu Arg Arg Arg Leu Phe Ser Tyr Pro Thr Lys 
1               5                   10                  15      


Tyr Tyr Phe Met Val Leu Val Leu Ser Leu Ile Thr Phe Ser Val Leu 
            20                  25                  30          


Arg Ile His Gln Lys Pro Glu Phe Val Ser Val Arg His Leu Glu Leu 
        35                  40                  45              


Ala Gly Glu Asn Pro Ser Ser Asp Ile Asn Cys Thr Lys Val Leu Gln 
    50                  55                  60                  


Gly Asp Val Asn Glu Ile Gln Lys Val Lys Leu Glu Ile Leu Thr Val 
65                  70                  75                  80  


Lys Phe Lys Lys Arg Pro Arg Trp Thr Pro Asp Asp Tyr Ile Asn Met 
                85                  90                  95      


Thr Ser Asp Cys Ser Ser Phe Ile Lys Arg Arg Lys Tyr Ile Val Glu 
            100                 105                 110         


Pro Leu Ser Lys Glu Glu Ala Glu Phe Pro Ile Ala Tyr Ser Ile Val 
        115                 120                 125             


Val His His Lys Ile Glu Met Leu Asp Arg Leu Leu Arg Ala Ile Tyr 
    130                 135                 140                 


Met Pro Gln Asn Phe Tyr Cys Ile His Val Asp Thr Lys Ser Glu Asp 
145                 150                 155                 160 


Ser Tyr Leu Ala Ala Val Met Gly Ile Ala Ser Cys Phe Ser Asn Val 
                165                 170                 175     


Phe Val Ala Ser Arg Leu Glu Ser Val Val Tyr Ala Ser Trp Ser Arg 
            180                 185                 190         


Val Gln Ala Asp Leu Asn Cys Met Lys Asp Leu Tyr Ala Met Ser Ala 
        195                 200                 205             


Asn Trp Lys Tyr Leu Ile Asn Leu Cys Gly Met Asp Phe Pro Ile Lys 
    210                 215                 220                 


Thr Asn Leu Glu Ile Val Arg Lys Leu Lys Leu Leu Met Gly Glu Asn 
225                 230                 235                 240 


Asn Leu Glu Thr Glu Arg Met Pro Ser His Lys Glu Glu Arg Trp Lys 
                245                 250                 255     


Lys Arg Tyr Glu Val Val Asn Gly Lys Leu Thr Asn Thr Gly Thr Val 
            260                 265                 270         


Lys Met Leu Pro Pro Leu Glu Thr Pro Leu Phe Ser Gly Ser Ala Tyr 
        275                 280                 285             


Phe Val Val Ser Arg Glu Tyr Val Gly Tyr Val Leu Gln Asn Glu Lys 
    290                 295                 300                 


Ile Gln Lys Leu Met Glu Trp Ala Gln Asp Thr Tyr Ser Pro Asp Glu 
305                 310                 315                 320 


Tyr Leu Trp Ala Thr Ile Gln Arg Ile Pro Glu Val Pro Gly Ser Leu 
                325                 330                 335     


Pro Ala Ser His Lys Tyr Asp Leu Ser Asp Met Gln Ala Val Ala Arg 
            340                 345                 350         


Phe Val Lys Trp Gln Tyr Phe Glu Gly Asp Val Ser Lys Gly Ala Pro 
        355                 360                 365             


Tyr Pro Pro Cys Asp Gly Val His Val Arg Ser Val Cys Ile Phe Gly 
    370                 375                 380                 


Ala Gly Asp Leu Asn Trp Met Leu Arg Lys His His Leu Phe Ala Asn 
385                 390                 395                 400 


Lys Phe Asp Val Asp Val Asp Leu Phe Ala Ile Gln Cys Leu Asp Glu 
                405                 410                 415     


His Leu Arg His Lys Ala Leu Glu Thr Leu Lys His 
            420                 425             


<210>  1107
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  1107

Met Leu Arg Thr Leu Leu Arg Arg Arg Leu Phe Ser Tyr Pro Thr Lys 
1               5                   10                  15      


Tyr Tyr Phe Met Val Leu Val Leu Ser Leu Ile Thr Phe Ser Val Leu 
            20                  25                  30          


Arg Ile His Gln Lys Pro Glu Phe Val Ser Val Arg His Leu Glu Leu 
        35                  40                  45              


Ala Gly Glu Asn Pro Ser Ser Asp Ile Asn Cys Thr Lys Val Leu Gln 
    50                  55                  60                  


Gly Asp Val Asn Glu Ile Gln Lys Val Lys Leu Glu Ile Leu Thr Val 
65                  70                  75                  80  


Lys Phe Lys Lys Arg Pro Arg Trp Thr Pro Asp Asp Tyr Ile Asn Met 
                85                  90                  95      


Thr Ser Asp Cys Ser Ser Phe Ile Lys Arg Arg Lys Tyr Ile Val Glu 
            100                 105                 110         


Pro Leu Ser Lys Glu Glu Ala Glu Phe Pro Ile Ala Tyr Ser Ile Val 
        115                 120                 125             


Val His His Lys Ile Glu Met Leu Asp Arg Leu Leu Arg Ala Ile Tyr 
    130                 135                 140                 


Met Pro Gln Asn Phe Tyr Cys Ile His Val Asp Thr Lys Ser Glu Asp 
145                 150                 155                 160 


Ser Tyr Leu Ala Ala Val Met Gly Ile Ala Ser Cys Phe Ser Asn Val 
                165                 170                 175     


Phe Val Ala Ser Arg Leu Glu Ser Val Val Tyr Ala Ser Trp Ser Arg 
            180                 185                 190         


Val Gln Ala Asp Leu Asn Cys Met Lys Asp Leu Tyr Ala Met Ser Ala 
        195                 200                 205             


Asn Trp Lys Tyr Leu Ile Asn Leu Cys Gly Met Asp Phe Pro Ile Lys 
    210                 215                 220                 


Thr Asn Leu Glu Ile Val Arg Lys Leu Lys Leu Leu Met Gly Glu Asn 
225                 230                 235                 240 


Asn Leu Glu Thr Glu Arg Met Pro Ser His Lys Glu Glu Arg Trp Lys 
                245                 250                 255     


Lys Arg Tyr Glu Val Val Asn Gly Lys Leu Thr Asn Thr Gly Thr Val 
            260                 265                 270         


Lys Met Leu Pro Pro Leu Glu Thr Pro Leu Phe Ser Gly Ser Ala Tyr 
        275                 280                 285             


Phe Val Val Ser Arg Glu Tyr Val Gly Tyr Val Leu Gln Asn Glu Lys 
    290                 295                 300                 


Ile Gln Lys Leu Met Glu Trp Ala Gln Asp Thr Tyr Ser Pro Asp Glu 
305                 310                 315                 320 


Tyr Leu Trp Ala Thr Ile Gln Arg Ile Pro Glu Val Pro Gly Ser Leu 
                325                 330                 335     


Pro Ala Ser His Lys Tyr Asp Leu Ser Asp Met Gln Ala Val Ala Arg 
            340                 345                 350         


Phe Val Lys Trp Gln Tyr Phe Glu Gly Asp Val Ser Lys Gly Ala Pro 
        355                 360                 365             


Tyr Pro Pro Cys Asp Gly Val His Val Arg Ser Val Cys Ile Phe Gly 
    370                 375                 380                 


Ala Gly Asp Leu Asn Trp Met Leu Arg Lys His His Leu Phe Ala Asn 
385                 390                 395                 400 


Lys Phe Asp Val Asp Val Asp Leu Phe Ala Ile Gln Cys Leu Asp Glu 
                405                 410                 415     


His Leu Arg His Lys Ala Leu Glu Thr Leu Lys His 
            420                 425             


<210>  1108
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  1108

Met Leu Arg Thr Leu Leu Arg Arg Arg Leu Phe Ser Tyr Pro Thr Lys 
1               5                   10                  15      


Tyr Tyr Phe Met Val Leu Val Leu Ser Leu Ile Thr Phe Ser Val Leu 
            20                  25                  30          


Arg Ile His Gln Lys Pro Glu Phe Val Ser Val Arg His Leu Glu Leu 
        35                  40                  45              


Ala Gly Glu Asn Pro Ser Ser Asp Ile Asn Cys Thr Lys Val Leu Gln 
    50                  55                  60                  


Gly Asp Val Asn Glu Ile Gln Lys Val Lys Leu Glu Ile Leu Thr Val 
65                  70                  75                  80  


Lys Phe Lys Lys Arg Pro Arg Trp Thr Pro Asp Asp Tyr Ile Asn Met 
                85                  90                  95      


Thr Ser Asp Cys Ser Ser Phe Ile Lys Arg Arg Lys Tyr Ile Val Glu 
            100                 105                 110         


Pro Leu Ser Lys Glu Glu Ala Glu Phe Pro Ile Ala Tyr Ser Ile Val 
        115                 120                 125             


Val His His Lys Ile Glu Met Leu Asp Arg Leu Leu Arg Ala Ile Tyr 
    130                 135                 140                 


Met Pro Gln Asn Phe Tyr Cys Ile His Val Asp Thr Lys Ser Glu Asp 
145                 150                 155                 160 


Ser Tyr Leu Ala Ala Val Met Gly Ile Ala Ser Cys Phe Ser Asn Val 
                165                 170                 175     


Phe Val Ala Ser Arg Leu Glu Ser Val Val Tyr Ala Ser Trp Ser Arg 
            180                 185                 190         


Val Gln Ala Asp Leu Asn Cys Met Lys Asp Leu Tyr Ala Met Ser Ala 
        195                 200                 205             


Asn Trp Lys Tyr Leu Ile Asn Leu Cys Gly Met Asp Phe Pro Ile Lys 
    210                 215                 220                 


Thr Asn Leu Glu Ile Val Arg Lys Leu Lys Leu Leu Met Gly Glu Asn 
225                 230                 235                 240 


Asn Leu Glu Thr Glu Arg Met Pro Ser His Lys Glu Glu Arg Trp Lys 
                245                 250                 255     


Lys Arg Tyr Glu Val Val Asn Gly Lys Leu Thr Asn Thr Gly Thr Val 
            260                 265                 270         


Lys Met Leu Pro Pro Leu Glu Thr Pro Leu Phe Ser Gly Ser Ala Tyr 
        275                 280                 285             


Phe Val Val Ser Arg Glu Tyr Val Gly Tyr Val Leu Gln Asn Glu Lys 
    290                 295                 300                 


Ile Gln Lys Leu Met Glu Trp Ala Gln Asp Thr Tyr Ser Pro Asp Glu 
305                 310                 315                 320 


Tyr Leu Trp Ala Thr Ile Gln Arg Ile Pro Glu Val Pro Gly Ser Leu 
                325                 330                 335     


Pro Ala Ser His Lys Tyr Asp Leu Ser Asp Met Gln Ala Val Ala Arg 
            340                 345                 350         


Phe Val Lys Trp Gln Tyr Phe Glu Gly Asp Val Ser Lys Gly Ala Pro 
        355                 360                 365             


Tyr Pro Pro Cys Asp Gly Val His Val Arg Ser Val Cys Ile Phe Gly 
    370                 375                 380                 


Ala Gly Asp Leu Asn Trp Met Leu Arg Lys His His Leu Phe Ala Asn 
385                 390                 395                 400 


Lys Phe Asp Val Asp Val Asp Leu Phe Ala Ile Gln Cys Leu Asp Glu 
                405                 410                 415     


His Leu Arg His Lys Ala Leu Glu Thr Leu Lys His 
            420                 425             


<210>  1109
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  1109

Met Leu Arg Thr Leu Leu Arg Arg Arg Leu Phe Ser Tyr Pro Thr Lys 
1               5                   10                  15      


Tyr Tyr Phe Met Val Leu Val Leu Ser Leu Ile Thr Phe Ser Val Leu 
            20                  25                  30          


Arg Ile His Gln Lys Pro Glu Phe Val Ser Val Arg His Leu Glu Leu 
        35                  40                  45              


Ala Gly Glu Asn Pro Ser Ser Asp Ile Asn Cys Thr Lys Val Leu Gln 
    50                  55                  60                  


Gly Asp Val Asn Glu Ile Gln Lys Val Lys Leu Glu Ile Leu Thr Val 
65                  70                  75                  80  


Lys Phe Lys Lys Arg Pro Arg Trp Thr Pro Asp Asp Tyr Ile Asn Met 
                85                  90                  95      


Thr Ser Asp Cys Ser Ser Phe Ile Lys Arg Arg Lys Tyr Ile Val Glu 
            100                 105                 110         


Pro Leu Ser Lys Glu Glu Ala Glu Phe Pro Ile Ala Tyr Ser Ile Val 
        115                 120                 125             


Val His His Lys Ile Glu Met Leu Asp Arg Leu Leu Arg Ala Ile Tyr 
    130                 135                 140                 


Met Pro Gln Asn Phe Tyr Cys Ile His Val Asp Thr Lys Ser Glu Asp 
145                 150                 155                 160 


Ser Tyr Leu Ala Ala Val Met Gly Ile Ala Ser Cys Phe Ser Asn Val 
                165                 170                 175     


Phe Val Ala Ser Arg Leu Glu Ser Val Val Tyr Ala Ser Trp Ser Arg 
            180                 185                 190         


Val Gln Ala Asp Leu Asn Cys Met Lys Asp Leu Tyr Ala Met Ser Ala 
        195                 200                 205             


Asn Trp Lys Tyr Leu Ile Asn Leu Cys Gly Met Asp Phe Pro Ile Lys 
    210                 215                 220                 


Thr Asn Leu Glu Ile Val Arg Lys Leu Lys Leu Leu Met Gly Glu Asn 
225                 230                 235                 240 


Asn Leu Glu Thr Glu Arg Met Pro Ser His Lys Glu Glu Arg Trp Lys 
                245                 250                 255     


Lys Arg Tyr Glu Val Val Asn Gly Lys Leu Thr Asn Thr Gly Thr Val 
            260                 265                 270         


Lys Met Leu Pro Pro Leu Glu Thr Pro Leu Phe Ser Gly Ser Ala Tyr 
        275                 280                 285             


Phe Val Val Ser Arg Glu Tyr Val Gly Tyr Val Leu Gln Asn Glu Lys 
    290                 295                 300                 


Ile Gln Lys Leu Met Glu Trp Ala Gln Asp Thr Tyr Ser Pro Asp Glu 
305                 310                 315                 320 


Tyr Leu Trp Ala Thr Ile Gln Arg Ile Pro Glu Val Pro Gly Ser Leu 
                325                 330                 335     


Pro Ala Ser His Lys Tyr Asp Leu Ser Asp Met Gln Ala Val Ala Arg 
            340                 345                 350         


Phe Val Lys Trp Gln Tyr Phe Glu Gly Asp Val Ser Lys Gly Ala Pro 
        355                 360                 365             


Tyr Pro Pro Cys Asp Gly Val His Val Arg Ser Val Cys Ile Phe Gly 
    370                 375                 380                 


Ala Gly Asp Leu Asn Trp Met Leu Arg Lys His His Leu Phe Ala Asn 
385                 390                 395                 400 


Lys Phe Asp Val Asp Val Asp Leu Phe Ala Ile Gln Cys Leu Asp Glu 
                405                 410                 415     


His Leu Arg His Lys Ala Leu Glu Thr Leu Lys His 
            420                 425             


<210>  1110
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  1110

Met Leu Val Val Gln Met Pro Phe Ser Phe Pro Met Ala His Phe Ile 
1               5                   10                  15      


Leu Phe Val Phe Thr Val Ser Thr Ile Phe His Val Gln Gln Arg Leu 
            20                  25                  30          


Ala Lys Ile Gln Ala Met Trp Glu Leu Pro Val Gln Ile Pro Val Leu 
        35                  40                  45              


Ala Ser Thr Ser Lys Ala Leu Gly Pro Ser Gln Leu Arg Gly Met Trp 
    50                  55                  60                  


Thr Ile Asn Ala Ile Gly Arg Leu Gly Asn Gln Met Gly Glu Tyr Ala 
65                  70                  75                  80  


Thr Leu Tyr Ala Leu Ala Lys Met Asn Gly Arg Pro Ala Phe Ile Pro 
                85                  90                  95      


Ala Gln Met His Ser Thr Leu Ala Pro Ile Phe Arg Ile Thr Leu Pro 
            100                 105                 110         


Val Leu His Ser Ala Thr Ala Ser Arg Ile Pro Trp Gln Asn Tyr His 
        115                 120                 125             


Leu Asn Asp Trp Met Glu Glu Glu Tyr Arg His Ile Pro Gly Glu Tyr 
    130                 135                 140                 


Val Arg Phe Thr Gly Tyr Pro Cys Ser Trp Thr Phe Tyr His His Leu 
145                 150                 155                 160 


Arg Gln Glu Ile Leu Gln Glu Phe Thr Leu His Asp His Val Arg Glu 
                165                 170                 175     


Glu Ala Gln Lys Phe Leu Arg Gly Leu Gln Val Asn Gly Ser Arg Pro 
            180                 185                 190         


Gly Thr Phe Val Gly Val His Val Arg Arg Gly Asp Tyr Val His Val 
        195                 200                 205             


Met Pro Lys Val Trp Lys Gly Val Val Ala Asp Arg Arg Tyr Leu Gln 
    210                 215                 220                 


Gln Ala Leu Asp Trp Phe Arg Ala Arg Tyr Ser Ser Leu Ile Phe Val 
225                 230                 235                 240 


Val Thr Ser Asn Gly Met Ala Trp Cys Arg Glu Asn Ile Asp Thr Ser 
                245                 250                 255     


His Gly Asp Val Val Phe Ala Gly Asp Gly Ile Glu Gly Ser Pro Ala 
            260                 265                 270         


Lys Asp Phe Ala Leu Leu Thr Gln Cys Asn His Thr Ile Met Thr Ile 
        275                 280                 285             


Gly Thr Phe Gly Ile Trp Ala Ala Tyr Leu Thr Gly Gly Asp Thr Ile 
    290                 295                 300                 


Tyr Leu Ala Asn Tyr Thr Leu Pro Asp Ser Pro Phe Leu Lys Ile Phe 
305                 310                 315                 320 


Lys Pro Glu Ala Ala Phe Leu Pro Glu Trp Thr Gly Ile Ala Ala Asp 
                325                 330                 335     


Leu Ser Pro Leu Leu Lys His 
            340             


<210>  1111
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  1111

Met Asp Pro Leu Gly Ala Ala Lys Pro Gln Trp Pro Trp Arg Arg Cys 
1               5                   10                  15      


Leu Ala Ala Leu Leu Phe Gln Leu Leu Val Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Arg Asp Asp Ala Thr Gly Ser Pro Arg Ala Pro 
        35                  40                  45              


Ser Gly Ser Ser Arg Gln Asp Thr Thr Pro Thr Arg Pro Thr Leu Leu 
    50                  55                  60                  


Ile Leu Leu Trp Thr Trp Pro Phe His Ile Pro Val Ala Leu Ser Arg 
65                  70                  75                  80  


Cys Ser Glu Met Val Pro Gly Thr Ala Asp Cys His Ile Thr Ala Asp 
                85                  90                  95      


Arg Lys Val Tyr Pro Gln Ala Asp Thr Val Ile Val His His Trp Asp 
            100                 105                 110         


Ile Met Ser Asn Pro Lys Ser Arg Leu Pro Pro Ser Pro Arg Pro Gln 
        115                 120                 125             


Gly Gln Arg Trp Ile Trp Phe Asn Leu Glu Pro Pro Pro Asn Cys Gln 
    130                 135                 140                 


His Leu Glu Ala Leu Asp Arg Tyr Phe Asn Leu Thr Met Ser Tyr Arg 
145                 150                 155                 160 


Ser Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser 
                165                 170                 175     


Gly Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu 
            180                 185                 190         


Val Ala Trp Ala Val Ser Asn Trp Lys Pro Asp Ser Ala Arg Val Arg 
        195                 200                 205             


Tyr Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg 
    210                 215                 220                 


Ser His Lys Pro Leu Pro Lys Gly Thr Met Met Glu Thr Leu Ser Arg 
225                 230                 235                 240 


Tyr Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile 
                245                 250                 255     


Thr Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val 
            260                 265                 270         


Val Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp 
        275                 280                 285             


Ala Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg 
    290                 295                 300                 


Tyr Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe 
305                 310                 315                 320 


Arg Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Asp 
                325                 330                 335     


Phe Cys Lys Ala Cys Trp Lys Leu Gln Gln Glu Ser Arg Tyr Gln Thr 
            340                 345                 350         


Val Arg Ser Ile Ala Ala Trp Phe Thr 
        355                 360     


<210>  1112
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  1112

Met Asp Pro Leu Gly Ala Ala Lys Pro Gln Trp Pro Trp Arg Arg Cys 
1               5                   10                  15      


Leu Ala Ala Leu Leu Phe Gln Leu Leu Val Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Arg Asp Asp Ala Thr Gly Ser Pro Arg Ala Pro 
        35                  40                  45              


Ser Gly Ser Ser Arg Gln Asp Thr Thr Pro Thr Arg Pro Thr Leu Leu 
    50                  55                  60                  


Ile Leu Leu Trp Thr Trp Pro Phe His Ile Pro Val Ala Leu Ser Arg 
65                  70                  75                  80  


Cys Ser Glu Met Val Pro Gly Thr Ala Asp Cys His Ile Thr Ala Asp 
                85                  90                  95      


Arg Lys Val Tyr Pro Gln Ala Asp Thr Val Ile Val His His Trp Asp 
            100                 105                 110         


Ile Met Ser Asn Pro Lys Ser Arg Leu Pro Pro Ser Pro Arg Pro Gln 
        115                 120                 125             


Gly Gln Arg Trp Ile Trp Phe Asn Leu Glu Pro Pro Pro Asn Cys Gln 
    130                 135                 140                 


His Leu Glu Ala Leu Asp Arg Tyr Phe Asn Leu Thr Met Ser Tyr Arg 
145                 150                 155                 160 


Ser Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser 
                165                 170                 175     


Gly Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu 
            180                 185                 190         


Val Ala Trp Ala Val Ser Asn Trp Lys Pro Asp Ser Ala Arg Val Arg 
        195                 200                 205             


Tyr Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg 
    210                 215                 220                 


Ser His Lys Pro Leu Pro Lys Gly Thr Met Met Glu Thr Leu Ser Arg 
225                 230                 235                 240 


Tyr Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile 
                245                 250                 255     


Thr Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val 
            260                 265                 270         


Val Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp 
        275                 280                 285             


Ala Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg 
    290                 295                 300                 


Tyr Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe 
305                 310                 315                 320 


Arg Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Asp 
                325                 330                 335     


Phe Cys Lys Ala Cys Trp Lys Leu Gln Gln Glu Ser Arg Tyr Gln Thr 
            340                 345                 350         


Val Arg Ser Ile Ala Ala Trp Phe Thr 
        355                 360     


<210>  1113
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  1113

Met Asp Pro Leu Gly Ala Ala Lys Pro Gln Trp Pro Trp Arg Arg Cys 
1               5                   10                  15      


Leu Ala Ala Leu Leu Phe Gln Leu Leu Val Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Arg Asp Asp Ala Thr Gly Ser Pro Arg Ala Pro 
        35                  40                  45              


Ser Gly Ser Ser Arg Gln Asp Thr Thr Pro Thr Arg Pro Thr Leu Leu 
    50                  55                  60                  


Ile Leu Leu Trp Thr Trp Pro Phe His Ile Pro Val Ala Leu Ser Arg 
65                  70                  75                  80  


Cys Ser Glu Met Val Pro Gly Thr Ala Asp Cys His Ile Thr Ala Asp 
                85                  90                  95      


Arg Lys Val Tyr Pro Gln Ala Asp Thr Val Ile Val His His Trp Asp 
            100                 105                 110         


Ile Met Ser Asn Pro Lys Ser Arg Leu Pro Pro Ser Pro Arg Pro Gln 
        115                 120                 125             


Gly Gln Arg Trp Ile Trp Phe Asn Leu Glu Pro Pro Pro Asn Cys Gln 
    130                 135                 140                 


His Leu Glu Ala Leu Asp Arg Tyr Phe Asn Leu Thr Met Ser Tyr Arg 
145                 150                 155                 160 


Ser Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser 
                165                 170                 175     


Gly Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu 
            180                 185                 190         


Val Ala Trp Ala Val Ser Asn Trp Lys Pro Asp Ser Ala Arg Val Arg 
        195                 200                 205             


Tyr Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg 
    210                 215                 220                 


Ser His Lys Pro Leu Pro Lys Gly Thr Met Met Glu Thr Leu Ser Arg 
225                 230                 235                 240 


Tyr Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile 
                245                 250                 255     


Thr Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val 
            260                 265                 270         


Val Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp 
        275                 280                 285             


Ala Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg 
    290                 295                 300                 


Tyr Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe 
305                 310                 315                 320 


Arg Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Asp 
                325                 330                 335     


Phe Cys Lys Ala Cys Trp Lys Leu Gln Gln Glu Ser Arg Tyr Gln Thr 
            340                 345                 350         


Val Arg Ser Ile Ala Ala Trp Phe Thr 
        355                 360     


<210>  1114
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  1114

Met Asn Trp Thr Gly Leu Tyr Thr Leu Leu Ser Gly Val Asn Arg His 
1               5                   10                  15      


Ser Thr Ala Ile Gly Arg Val Trp Leu Ser Val Ile Phe Ile Phe Arg 
            20                  25                  30          


Ile Met Val Leu Val Val Ala Ala Glu Ser Val Trp Gly Asp Glu Lys 
        35                  40                  45              


Ser Ser Phe Ile Cys Asn Thr Leu Gln Pro Gly Cys Asn Ser Val Cys 
    50                  55                  60                  


Tyr Asp Gln Phe Phe Pro Ile Ser His Val Arg Leu Trp Ser Leu Gln 
65                  70                  75                  80  


Leu Ile Leu Val Ser Thr Pro Ala Leu Leu Val Ala Met His Val Ala 
                85                  90                  95      


His Gln Gln His Ile Glu Lys Lys Met Leu Arg Leu Glu Gly His Gly 
            100                 105                 110         


Asp Pro Leu His Leu Glu Glu Val Lys Arg His Lys Val His Ile Ser 
        115                 120                 125             


Gly Thr Leu Trp Trp Thr Tyr Val Ile Ser Val Val Phe Arg Leu Leu 
    130                 135                 140                 


Phe Glu Ala Val Phe Met Tyr Val Phe Tyr Leu Leu Tyr Pro Gly Tyr 
145                 150                 155                 160 


Ala Met Val Arg Leu Val Lys Cys Asp Val Tyr Pro Cys Pro Asn Thr 
                165                 170                 175     


Val Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr Val Phe Thr Val 
            180                 185                 190         


Phe Met Leu Ala Ala Ser Gly Ile Cys Ile Ile Leu Asn Val Ala Glu 
        195                 200                 205             


Val Val Tyr Leu Ile Ile Arg Ala Cys Ala Arg Arg Ala Gln Arg Arg 
    210                 215                 220                 


Ser Asn Pro Pro Ser Arg Lys Gly Ser Gly Phe Gly His Arg Leu Ser 
225                 230                 235                 240 


Pro Glu Tyr Lys Gln Asn Glu Ile Asn Lys Leu Leu Ser Glu Gln Asp 
                245                 250                 255     


Gly Ser Leu Lys Asp Ile Leu Arg Arg Ser Pro Gly Thr Gly Ala Gly 
            260                 265                 270         


Leu Ala Glu Lys Ser Asp Arg Cys Ser Ala Cys 
        275                 280             


<210>  1115
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  1115

Met Lys Gly Thr Lys Asp Leu Thr Ser Gln Gln Lys Glu Ser Asn Val 
1               5                   10                  15      


Lys Thr Phe Cys Ser Lys Asn Ile Leu Ala Ile Leu Gly Phe Ser Ser 
            20                  25                  30          


Ile Ile Ala Val Ile Ala Leu Leu Ala Val Gly Leu Thr Gln Asn Lys 
        35                  40                  45              


Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser 
    50                  55                  60                  


Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn 
65                  70                  75                  80  


Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg Val Lys Gly Pro 
                85                  90                  95      


Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile Gly Ile Tyr Leu 
            100                 105                 110         


Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro Arg Ser Gln His 
        115                 120                 125             


Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly Met Arg Leu Leu 
    130                 135                 140                 


Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu Asp Val Val Glu 
145                 150                 155                 160 


Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile 
                165                 170                 175     


Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu 
            180                 185                 190         


Leu Gly Lys Phe Ser Gln Lys Thr Arg Trp Phe Ser Ile Val Pro Tyr 
        195                 200                 205             


Glu Thr Asn Asn Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala 
    210                 215                 220                 


Ser Thr Gln Val Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro 
225                 230                 235                 240 


Asp Asn Ala Leu Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr 
                245                 250                 255     


Thr His Ser Phe Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys 
            260                 265                 270         


Leu Ala Lys Asp Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro 
        275                 280                 285             


Cys Phe His Pro Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr 
    290                 295                 300                 


Lys Thr Pro Cys Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln 
305                 310                 315                 320 


Phe Glu Ile Gln Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile 
                325                 330                 335     


Leu Glu Leu Phe Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe 
            340                 345                 350         


Asn Gly Ile Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser 
        355                 360                 365             


Ala Phe Tyr Phe Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val 
    370                 375                 380                 


Ser Gln Glu Lys Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro 
385                 390                 395                 400 


Trp Glu Glu Ile Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu 
                405                 410                 415     


Ser Glu Tyr Cys Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln 
            420                 425                 430         


Gly Tyr His Phe Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly 
        435                 440                 445             


Lys Ile Gln Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn 
    450                 455                 460                 


Leu Thr Asn Met Ile Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser 
465                 470                 475                 480 


His Ser Thr Tyr Val Phe Leu Met Val Leu Phe Ser Leu Val Leu Phe 
                485                 490                 495     


Thr Val Ala Ile Ile Gly Leu Leu Ile Phe His Lys Pro Ser Tyr Phe 
            500                 505                 510         


Trp Lys Asp Met Val 
        515         


<210>  1116
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  1116

Met Glu Asp Leu Glu Glu Thr Leu Phe Glu Glu Phe Glu Asn Tyr Ser 
1               5                   10                  15      


Tyr Asp Leu Asp Tyr Tyr Ser Leu Glu Ser Asp Leu Glu Glu Lys Val 
            20                  25                  30          


Gln Leu Gly Val Val His Trp Val Ser Leu Val Leu Tyr Cys Leu Ala 
        35                  40                  45              


Phe Val Leu Gly Ile Pro Gly Asn Ala Ile Val Ile Trp Phe Thr Gly 
    50                  55                  60                  


Phe Lys Trp Lys Lys Thr Val Thr Thr Leu Trp Phe Leu Asn Leu Ala 
65                  70                  75                  80  


Ile Ala Asp Phe Ile Phe Leu Leu Phe Leu Pro Leu Tyr Ile Ser Tyr 
                85                  90                  95      


Val Ala Met Asn Phe His Trp Pro Phe Gly Ile Trp Leu Cys Lys Ala 
            100                 105                 110         


Asn Ser Phe Thr Ala Gln Leu Asn Met Phe Ala Ser Val Phe Phe Leu 
        115                 120                 125             


Thr Val Ile Ser Leu Asp His Tyr Ile His Leu Ile His Pro Val Leu 
    130                 135                 140                 


Ser His Arg His Arg Thr Leu Lys Asn Ser Leu Ile Val Ile Ile Phe 
145                 150                 155                 160 


Ile Trp Leu Leu Ala Ser Leu Ile Gly Gly Pro Ala Leu Tyr Phe Arg 
                165                 170                 175     


Asp Thr Val Glu Phe Asn Asn His Thr Leu Cys Tyr Asn Asn Phe Gln 
            180                 185                 190         


Lys His Asp Pro Asp Leu Thr Leu Ile Arg His His Val Leu Thr Trp 
        195                 200                 205             


Val Lys Phe Ile Ile Gly Tyr Leu Phe Pro Leu Leu Thr Met Ser Ile 
    210                 215                 220                 


Cys Tyr Leu Cys Leu Ile Phe Lys Val Lys Lys Arg Ser Ile Leu Ile 
225                 230                 235                 240 


Ser Ser Arg His Phe Trp Thr Ile Leu Val Val Val Val Ala Phe Val 
                245                 250                 255     


Val Cys Trp Thr Pro Tyr His Leu Phe Ser Ile Trp Glu Leu Thr Ile 
            260                 265                 270         


His His Asn Ser Tyr Ser His His Val Met Gln Ala Gly Ile Pro Leu 
        275                 280                 285             


Ser Thr Gly Leu Ala Phe Leu Asn Ser Cys Leu Asn Pro Ile Leu Tyr 
    290                 295                 300                 


Val Leu Ile Ser Lys Lys Phe Gln Ala Arg Phe Arg Ser Ser Val Ala 
305                 310                 315                 320 


Glu Ile Leu Lys Tyr Thr Leu Trp Glu Val Ser Cys Ser Gly Thr Val 
                325                 330                 335     


Ser Glu Gln Leu Arg Asn Ser Glu Thr Lys Asn Leu Cys Leu Leu Glu 
            340                 345                 350         


Thr Ala Gln 
        355 


<210>  1117
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  1117

Met Ile Thr Leu Asn Asn Gln Asp Gln Pro Val Pro Phe Asn Ser Ser 
1               5                   10                  15      


His Pro Asp Glu Tyr Lys Ile Ala Ala Leu Val Phe Tyr Ser Cys Ile 
            20                  25                  30          


Phe Ile Ile Gly Leu Phe Val Asn Ile Thr Ala Leu Trp Val Phe Ser 
        35                  40                  45              


Cys Thr Thr Lys Lys Arg Thr Thr Val Thr Ile Tyr Met Met Asn Val 
    50                  55                  60                  


Ala Leu Val Asp Leu Ile Phe Ile Met Thr Leu Pro Phe Arg Met Phe 
65                  70                  75                  80  


Tyr Tyr Ala Lys Asp Glu Trp Pro Phe Gly Glu Tyr Phe Cys Gln Ile 
                85                  90                  95      


Leu Gly Ala Leu Thr Val Phe Tyr Pro Ser Ile Ala Leu Trp Leu Leu 
            100                 105                 110         


Ala Phe Ile Ser Ala Asp Arg Tyr Met Ala Ile Val Gln Pro Lys Tyr 
        115                 120                 125             


Ala Lys Glu Leu Lys Asn Thr Cys Lys Ala Val Leu Ala Cys Val Gly 
    130                 135                 140                 


Val Trp Ile Met Thr Leu Thr Thr Thr Thr Pro Leu Leu Leu Leu Tyr 
145                 150                 155                 160 


Lys Asp Pro Asp Lys Asp Ser Thr Pro Ala Thr Cys Leu Lys Ile Ser 
                165                 170                 175     


Asp Ile Ile Tyr Leu Lys Ala Val Asn Val Leu Asn Leu Thr Arg Leu 
            180                 185                 190         


Thr Phe Phe Phe Leu Ile Pro Leu Phe Ile Met Ile Gly Cys Tyr Leu 
        195                 200                 205             


Val Ile Ile His Asn Leu Leu His Gly Arg Thr Ser Lys Leu Lys Pro 
    210                 215                 220                 


Lys Val Lys Glu Lys Ser Ile Arg Ile Ile Ile Thr Leu Leu Val Gln 
225                 230                 235                 240 


Val Leu Val Cys Phe Met Pro Phe His Ile Cys Phe Ala Phe Leu Met 
                245                 250                 255     


Leu Gly Thr Gly Glu Asn Ser Tyr Asn Pro Trp Gly Ala Phe Thr Thr 
            260                 265                 270         


Phe Leu Met Asn Leu Ser Thr Cys Leu Asp Val Ile Leu Tyr Tyr Ile 
        275                 280                 285             


Val Ser Lys Gln Phe Gln Ala Arg Val Ile Ser Val Met Leu Tyr Arg 
    290                 295                 300                 


Asn Tyr Leu Arg Ser Met Arg Arg Lys Ser Phe Arg Ser Gly Ser Leu 
305                 310                 315                 320 


Arg Ser Leu Ser Asn Ile Asn Ser Glu Met Leu 
                325                 330     


<210>  1118
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  1118

Met Asp Val Thr Ser Gln Ala Arg Gly Val Gly Leu Glu Met Tyr Pro 
1               5                   10                  15      


Gly Thr Ala Gln Pro Ala Ala Pro Asn Thr Thr Ser Pro Glu Leu Asn 
            20                  25                  30          


Leu Ser His Pro Leu Leu Gly Thr Ala Leu Ala Asn Gly Thr Gly Glu 
        35                  40                  45              


Leu Ser Glu His Gln Gln Tyr Val Ile Gly Leu Phe Leu Ser Cys Leu 
    50                  55                  60                  


Tyr Thr Ile Phe Leu Phe Pro Ile Gly Phe Val Gly Asn Ile Leu Ile 
65                  70                  75                  80  


Leu Val Val Asn Ile Ser Phe Arg Glu Lys Met Thr Ile Pro Asp Leu 
                85                  90                  95      


Tyr Phe Ile Asn Leu Ala Val Ala Asp Leu Ile Leu Val Ala Asp Ser 
            100                 105                 110         


Leu Ile Glu Val Phe Asn Leu His Glu Arg Tyr Tyr Asp Ile Ala Val 
        115                 120                 125             


Leu Cys Thr Phe Met Ser Leu Phe Leu Gln Val Asn Met Tyr Ser Ser 
    130                 135                 140                 


Val Phe Phe Leu Thr Trp Met Ser Phe Asp Arg Tyr Ile Ala Leu Ala 
145                 150                 155                 160 


Arg Ala Met Arg Cys Ser Leu Phe Arg Thr Lys His His Ala Arg Leu 
                165                 170                 175     


Ser Cys Gly Leu Ile Trp Met Ala Ser Val Ser Ala Thr Leu Val Pro 
            180                 185                 190         


Phe Thr Ala Val His Leu Gln His Thr Asp Glu Ala Cys Phe Cys Phe 
        195                 200                 205             


Ala Asp Val Arg Glu Val Gln Trp Leu Glu Val Thr Leu Gly Phe Ile 
    210                 215                 220                 


Val Pro Phe Ala Ile Ile Gly Leu Cys Tyr Ser Leu Ile Val Arg Val 
225                 230                 235                 240 


Leu Val Arg Ala His Arg His Arg Gly Leu Arg Pro Arg Arg Gln Lys 
                245                 250                 255     


Ala Leu Arg Met Ile Leu Ala Val Val Leu Val Phe Phe Val Cys Trp 
            260                 265                 270         


Leu Pro Glu Asn Val Phe Ile Ser Val His Leu Leu Gln Arg Thr Gln 
        275                 280                 285             


Pro Gly Ala Ala Pro Cys Lys Gln Ser Phe Arg His Ala His Pro Leu 
    290                 295                 300                 


Thr Gly His Ile Val Asn Leu Ala Ala Phe Ser Asn Ser Cys Leu Asn 
305                 310                 315                 320 


Pro Leu Ile Tyr Ser Phe Leu Gly Glu Thr Phe Arg Asp Lys Leu Arg 
                325                 330                 335     


Leu Tyr Ile Glu Gln Lys Thr Asn Leu Pro Ala Leu Asn Arg Phe Cys 
            340                 345                 350         


His Ala Ala Leu Lys Ala Val Ile Pro Asp Ser Thr Glu Gln Ser Asp 
        355                 360                 365             


Val Arg Phe Ser Ser Ala Val 
    370                 375 


<210>  1119
<211>  487
<212>  PRT
<213>  Homo sapiens

<400>  1119

Met Ser Leu Pro Asn Ser Ser Cys Leu Leu Glu Asp Lys Met Cys Glu 
1               5                   10                  15      


Gly Asn Lys Thr Thr Met Ala Ser Pro Gln Leu Met Pro Leu Val Val 
            20                  25                  30          


Val Leu Ser Thr Ile Cys Leu Val Thr Val Gly Leu Asn Leu Leu Val 
        35                  40                  45              


Leu Tyr Ala Val Arg Ser Glu Arg Lys Leu His Thr Val Gly Asn Leu 
    50                  55                  60                  


Tyr Ile Val Ser Leu Ser Val Ala Asp Leu Ile Val Gly Ala Val Val 
65                  70                  75                  80  


Met Pro Met Asn Ile Leu Tyr Leu Leu Met Ser Lys Trp Ser Leu Gly 
                85                  90                  95      


Arg Pro Leu Cys Leu Phe Trp Leu Ser Met Asp Tyr Val Ala Ser Thr 
            100                 105                 110         


Ala Ser Ile Phe Ser Val Phe Ile Leu Cys Ile Asp Arg Tyr Arg Ser 
        115                 120                 125             


Val Gln Gln Pro Leu Arg Tyr Leu Lys Tyr Arg Thr Lys Thr Arg Ala 
    130                 135                 140                 


Ser Ala Thr Ile Leu Gly Ala Trp Phe Leu Ser Phe Leu Trp Val Ile 
145                 150                 155                 160 


Pro Ile Leu Gly Trp Asn His Phe Met Gln Gln Thr Ser Val Arg Arg 
                165                 170                 175     


Glu Asp Lys Cys Glu Thr Asp Phe Tyr Asp Val Thr Trp Phe Lys Val 
            180                 185                 190         


Met Thr Ala Ile Ile Asn Phe Tyr Leu Pro Thr Leu Leu Met Leu Trp 
        195                 200                 205             


Phe Tyr Ala Lys Ile Tyr Lys Ala Val Arg Gln His Cys Gln His Arg 
    210                 215                 220                 


Glu Leu Ile Asn Arg Ser Leu Pro Ser Phe Ser Glu Ile Lys Leu Arg 
225                 230                 235                 240 


Pro Glu Asn Pro Lys Gly Asp Ala Lys Lys Pro Gly Lys Glu Ser Pro 
                245                 250                 255     


Trp Glu Val Leu Lys Arg Lys Pro Lys Asp Ala Gly Gly Gly Ser Val 
            260                 265                 270         


Leu Lys Ser Pro Ser Gln Thr Pro Lys Glu Met Lys Ser Pro Val Val 
        275                 280                 285             


Phe Ser Gln Glu Asp Asp Arg Glu Val Asp Lys Leu Tyr Cys Phe Pro 
    290                 295                 300                 


Leu Asp Ile Val His Met Gln Ala Ala Ala Glu Gly Ser Ser Arg Asp 
305                 310                 315                 320 


Tyr Val Ala Val Asn Arg Ser His Gly Gln Leu Lys Thr Asp Glu Gln 
                325                 330                 335     


Gly Leu Asn Thr His Gly Ala Ser Glu Ile Ser Glu Asp Gln Met Leu 
            340                 345                 350         


Gly Asp Ser Gln Ser Phe Ser Arg Thr Asp Ser Asp Thr Thr Thr Glu 
        355                 360                 365             


Thr Ala Pro Gly Lys Gly Lys Leu Arg Ser Gly Ser Asn Thr Gly Leu 
    370                 375                 380                 


Asp Tyr Ile Lys Phe Thr Trp Lys Arg Leu Arg Ser His Ser Arg Gln 
385                 390                 395                 400 


Tyr Val Ser Gly Leu His Met Asn Arg Glu Arg Lys Ala Ala Lys Gln 
                405                 410                 415     


Leu Gly Phe Ile Met Ala Ala Phe Ile Leu Cys Trp Ile Pro Tyr Phe 
            420                 425                 430         


Ile Phe Phe Met Val Ile Ala Phe Cys Lys Asn Cys Cys Asn Glu His 
        435                 440                 445             


Leu His Met Phe Thr Ile Trp Leu Gly Tyr Ile Asn Ser Thr Leu Asn 
    450                 455                 460                 


Pro Leu Ile Tyr Pro Leu Cys Asn Glu Asn Phe Lys Lys Thr Phe Lys 
465                 470                 475                 480 


Arg Ile Leu His Ile Arg Ser 
                485         


<210>  1120
<211>  487
<212>  PRT
<213>  Homo sapiens

<400>  1120

Met Ser Leu Pro Asn Ser Ser Cys Leu Leu Glu Asp Lys Met Cys Glu 
1               5                   10                  15      


Gly Asn Lys Thr Thr Met Ala Ser Pro Gln Leu Met Pro Leu Val Val 
            20                  25                  30          


Val Leu Ser Thr Ile Cys Leu Val Thr Val Gly Leu Asn Leu Leu Val 
        35                  40                  45              


Leu Tyr Ala Val Arg Ser Glu Arg Lys Leu His Thr Val Gly Asn Leu 
    50                  55                  60                  


Tyr Ile Val Ser Leu Ser Val Ala Asp Leu Ile Val Gly Ala Val Val 
65                  70                  75                  80  


Met Pro Met Asn Ile Leu Tyr Leu Leu Met Ser Lys Trp Ser Leu Gly 
                85                  90                  95      


Arg Pro Leu Cys Leu Phe Trp Leu Ser Met Asp Tyr Val Ala Ser Thr 
            100                 105                 110         


Ala Ser Ile Phe Ser Val Phe Ile Leu Cys Ile Asp Arg Tyr Arg Ser 
        115                 120                 125             


Val Gln Gln Pro Leu Arg Tyr Leu Lys Tyr Arg Thr Lys Thr Arg Ala 
    130                 135                 140                 


Ser Ala Thr Ile Leu Gly Ala Trp Phe Leu Ser Phe Leu Trp Val Ile 
145                 150                 155                 160 


Pro Ile Leu Gly Trp Asn His Phe Met Gln Gln Thr Ser Val Arg Arg 
                165                 170                 175     


Glu Asp Lys Cys Glu Thr Asp Phe Tyr Asp Val Thr Trp Phe Lys Val 
            180                 185                 190         


Met Thr Ala Ile Ile Asn Phe Tyr Leu Pro Thr Leu Leu Met Leu Trp 
        195                 200                 205             


Phe Tyr Ala Lys Ile Tyr Lys Ala Val Arg Gln His Cys Gln His Arg 
    210                 215                 220                 


Glu Leu Ile Asn Arg Ser Leu Pro Ser Phe Ser Glu Ile Lys Leu Arg 
225                 230                 235                 240 


Pro Glu Asn Pro Lys Gly Asp Ala Lys Lys Pro Gly Lys Glu Ser Pro 
                245                 250                 255     


Trp Glu Val Leu Lys Arg Lys Pro Lys Asp Ala Gly Gly Gly Ser Val 
            260                 265                 270         


Leu Lys Ser Pro Ser Gln Thr Pro Lys Glu Met Lys Ser Pro Val Val 
        275                 280                 285             


Phe Ser Gln Glu Asp Asp Arg Glu Val Asp Lys Leu Tyr Cys Phe Pro 
    290                 295                 300                 


Leu Asp Ile Val His Met Gln Ala Ala Ala Glu Gly Ser Ser Arg Asp 
305                 310                 315                 320 


Tyr Val Ala Val Asn Arg Ser His Gly Gln Leu Lys Thr Asp Glu Gln 
                325                 330                 335     


Gly Leu Asn Thr His Gly Ala Ser Glu Ile Ser Glu Asp Gln Met Leu 
            340                 345                 350         


Gly Asp Ser Gln Ser Phe Ser Arg Thr Asp Ser Asp Thr Thr Thr Glu 
        355                 360                 365             


Thr Ala Pro Gly Lys Gly Lys Leu Arg Ser Gly Ser Asn Thr Gly Leu 
    370                 375                 380                 


Asp Tyr Ile Lys Phe Thr Trp Lys Arg Leu Arg Ser His Ser Arg Gln 
385                 390                 395                 400 


Tyr Val Ser Gly Leu His Met Asn Arg Glu Arg Lys Ala Ala Lys Gln 
                405                 410                 415     


Leu Gly Phe Ile Met Ala Ala Phe Ile Leu Cys Trp Ile Pro Tyr Phe 
            420                 425                 430         


Ile Phe Phe Met Val Ile Ala Phe Cys Lys Asn Cys Cys Asn Glu His 
        435                 440                 445             


Leu His Met Phe Thr Ile Trp Leu Gly Tyr Ile Asn Ser Thr Leu Asn 
    450                 455                 460                 


Pro Leu Ile Tyr Pro Leu Cys Asn Glu Asn Phe Lys Lys Thr Phe Lys 
465                 470                 475                 480 


Arg Ile Leu His Ile Arg Ser 
                485         


<210>  1121
<211>  487
<212>  PRT
<213>  Homo sapiens

<400>  1121

Met Ser Leu Pro Asn Ser Ser Cys Leu Leu Glu Asp Lys Met Cys Glu 
1               5                   10                  15      


Gly Asn Lys Thr Thr Met Ala Ser Pro Gln Leu Met Pro Leu Val Val 
            20                  25                  30          


Val Leu Ser Thr Ile Cys Leu Val Thr Val Gly Leu Asn Leu Leu Val 
        35                  40                  45              


Leu Tyr Ala Val Arg Ser Glu Arg Lys Leu His Thr Val Gly Asn Leu 
    50                  55                  60                  


Tyr Ile Val Ser Leu Ser Val Ala Asp Leu Ile Val Gly Ala Val Val 
65                  70                  75                  80  


Met Pro Met Asn Ile Leu Tyr Leu Leu Met Ser Lys Trp Ser Leu Gly 
                85                  90                  95      


Arg Pro Leu Cys Leu Phe Trp Leu Ser Met Asp Tyr Val Ala Ser Thr 
            100                 105                 110         


Ala Ser Ile Phe Ser Val Phe Ile Leu Cys Ile Asp Arg Tyr Arg Ser 
        115                 120                 125             


Val Gln Gln Pro Leu Arg Tyr Leu Lys Tyr Arg Thr Lys Thr Arg Ala 
    130                 135                 140                 


Ser Ala Thr Ile Leu Gly Ala Trp Phe Leu Ser Phe Leu Trp Val Ile 
145                 150                 155                 160 


Pro Ile Leu Gly Trp Asn His Phe Met Gln Gln Thr Ser Val Arg Arg 
                165                 170                 175     


Glu Asp Lys Cys Glu Thr Asp Phe Tyr Asp Val Thr Trp Phe Lys Val 
            180                 185                 190         


Met Thr Ala Ile Ile Asn Phe Tyr Leu Pro Thr Leu Leu Met Leu Trp 
        195                 200                 205             


Phe Tyr Ala Lys Ile Tyr Lys Ala Val Arg Gln His Cys Gln His Arg 
    210                 215                 220                 


Glu Leu Ile Asn Arg Ser Leu Pro Ser Phe Ser Glu Ile Lys Leu Arg 
225                 230                 235                 240 


Pro Glu Asn Pro Lys Gly Asp Ala Lys Lys Pro Gly Lys Glu Ser Pro 
                245                 250                 255     


Trp Glu Val Leu Lys Arg Lys Pro Lys Asp Ala Gly Gly Gly Ser Val 
            260                 265                 270         


Leu Lys Ser Pro Ser Gln Thr Pro Lys Glu Met Lys Ser Pro Val Val 
        275                 280                 285             


Phe Ser Gln Glu Asp Asp Arg Glu Val Asp Lys Leu Tyr Cys Phe Pro 
    290                 295                 300                 


Leu Asp Ile Val His Met Gln Ala Ala Ala Glu Gly Ser Ser Arg Asp 
305                 310                 315                 320 


Tyr Val Ala Val Asn Arg Ser His Gly Gln Leu Lys Thr Asp Glu Gln 
                325                 330                 335     


Gly Leu Asn Thr His Gly Ala Ser Glu Ile Ser Glu Asp Gln Met Leu 
            340                 345                 350         


Gly Asp Ser Gln Ser Phe Ser Arg Thr Asp Ser Asp Thr Thr Thr Glu 
        355                 360                 365             


Thr Ala Pro Gly Lys Gly Lys Leu Arg Ser Gly Ser Asn Thr Gly Leu 
    370                 375                 380                 


Asp Tyr Ile Lys Phe Thr Trp Lys Arg Leu Arg Ser His Ser Arg Gln 
385                 390                 395                 400 


Tyr Val Ser Gly Leu His Met Asn Arg Glu Arg Lys Ala Ala Lys Gln 
                405                 410                 415     


Leu Gly Phe Ile Met Ala Ala Phe Ile Leu Cys Trp Ile Pro Tyr Phe 
            420                 425                 430         


Ile Phe Phe Met Val Ile Ala Phe Cys Lys Asn Cys Cys Asn Glu His 
        435                 440                 445             


Leu His Met Phe Thr Ile Trp Leu Gly Tyr Ile Asn Ser Thr Leu Asn 
    450                 455                 460                 


Pro Leu Ile Tyr Pro Leu Cys Asn Glu Asn Phe Lys Lys Thr Phe Lys 
465                 470                 475                 480 


Arg Ile Leu His Ile Arg Ser 
                485         


<210>  1122
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  1122

Met Lys Met Arg Arg Tyr Lys Leu Phe Leu Met Phe Cys Met Ala Gly 
1               5                   10                  15      


Leu Cys Leu Ile Ser Phe Leu His Phe Phe Lys Thr Leu Ser Tyr Val 
            20                  25                  30          


Thr Phe Pro Arg Glu Leu Ala Ser Leu Ser Pro Asn Leu Val Ser Ser 
        35                  40                  45              


Phe Phe Trp Asn Asn Ala Pro Val Thr Pro Gln Ala Ser Pro Glu Pro 
    50                  55                  60                  


Gly Gly Pro Asp Leu Leu Arg Thr Pro Leu Tyr Ser His Ser Pro Leu 
65                  70                  75                  80  


Leu Gln Pro Leu Pro Pro Ser Lys Ala Ala Glu Glu Leu His Arg Val 
                85                  90                  95      


Asp Leu Val Leu Pro Glu Asp Thr Thr Glu Tyr Phe Val Arg Thr Lys 
            100                 105                 110         


Ala Gly Gly Val Cys Phe Lys Pro Gly Thr Lys Met Leu Glu Arg Pro 
        115                 120                 125             


Pro Pro Gly Arg Pro Glu Glu Lys Pro Glu Gly Ala Asn Gly Ser Ser 
    130                 135                 140                 


Ala Arg Arg Pro Pro Arg Tyr Leu Leu Ser Ala Arg Glu Arg Thr Gly 
145                 150                 155                 160 


Gly Arg Gly Ala Arg Arg Lys Trp Val Glu Cys Val Cys Leu Pro Gly 
                165                 170                 175     


Trp His Gly Pro Ser Cys Gly Val Pro Thr Val Val Gln Tyr Ser Asn 
            180                 185                 190         


Leu Pro Thr Lys Glu Arg Leu Val Pro Arg Glu Val Pro Arg Arg Val 
        195                 200                 205             


Ile Asn Ala Ile Asn Val Asn His Glu Phe Asp Leu Leu Asp Val Arg 
    210                 215                 220                 


Phe His Glu Leu Gly Asp Val Val Asp Ala Phe Val Val Cys Glu Ser 
225                 230                 235                 240 


Asn Phe Thr Ala Tyr Gly Glu Pro Arg Pro Leu Lys Phe Arg Glu Met 
                245                 250                 255     


Leu Thr Asn Gly Thr Phe Glu Tyr Ile Arg His Lys Val Leu Tyr Val 
            260                 265                 270         


Phe Leu Asp His Phe Pro Pro Gly Gly Arg Gln Asp Gly Trp Ile Ala 
        275                 280                 285             


Asp Asp Tyr Leu Arg Thr Phe Leu Thr Gln Asp Gly Val Ser Arg Leu 
    290                 295                 300                 


Arg Asn Leu Arg Pro Asp Asp Val Phe Ile Ile Asp Asp Ala Asp Glu 
305                 310                 315                 320 


Ile Pro Ala Arg Asp Gly Val Leu Phe Leu Lys Leu Tyr Asp Gly Trp 
                325                 330                 335     


Thr Glu Pro Phe Ala Phe His Met Arg Lys Ser Leu Tyr Gly Phe Phe 
            340                 345                 350         


Trp Lys Gln Pro Gly Thr Leu Glu Val Val Ser Gly Cys Thr Val Asp 
        355                 360                 365             


Met Leu Gln Ala Val Tyr Gly Leu Asp Gly Ile Arg Leu Arg Arg Arg 
    370                 375                 380                 


Gln Tyr Tyr Thr Met Pro Asn Phe Arg Gln Tyr Glu Asn Arg Thr Gly 
385                 390                 395                 400 


His Ile Leu Val Gln Trp Ser Leu Gly Ser Pro Leu His Phe Ala Gly 
                405                 410                 415     


Trp His Cys Ser Trp Cys Phe Thr Pro Glu Gly Ile Tyr Phe Lys Leu 
            420                 425                 430         


Val Ser Ala Gln Asn Gly Asp Phe Pro Arg Trp Gly Asp Tyr Glu Asp 
        435                 440                 445             


Lys Arg Asp Leu Asn Tyr Ile Arg Gly Leu Ile Arg Thr Gly Gly Trp 
    450                 455                 460                 


Phe Asp Gly Thr Gln Gln Glu Tyr Pro Pro Ala Asp Pro Ser Glu His 
465                 470                 475                 480 


Met Tyr Ala Pro Lys Tyr Leu Leu Lys Asn Tyr Asp Arg Phe His Tyr 
                485                 490                 495     


Leu Leu Asp Asn Pro Tyr Gln Glu Pro Arg Ser Thr Ala Ala Gly Gly 
            500                 505                 510         


Trp Arg His Arg Gly Pro Glu Gly Arg Pro Pro Ala Arg Gly Lys Leu 
        515                 520                 525             


Asp Glu Ala Glu Val 
    530             


<210>  1123
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  1123

Met Ala Pro Arg Ser Leu Leu Leu Leu Leu Ser Gly Ala Leu Ala Leu 
1               5                   10                  15      


Thr Asp Thr Trp Ala Gly Ser His Ser Leu Arg Tyr Phe Ser Thr Ala 
            20                  25                  30          


Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Tyr Ile Ala Val Glu Tyr 
        35                  40                  45              


Val Asp Asp Thr Gln Phe Leu Arg Phe Asp Ser Asp Ala Ala Ile Pro 
    50                  55                  60                  


Arg Met Glu Pro Arg Glu Pro Trp Val Glu Gln Glu Gly Pro Gln Tyr 
65                  70                  75                  80  


Trp Glu Trp Thr Thr Gly Tyr Ala Lys Ala Asn Ala Gln Thr Asp Arg 
                85                  90                  95      


Val Ala Leu Arg Asn Leu Leu Arg Arg Tyr Asn Gln Ser Glu Ala Gly 
            100                 105                 110         


Ser His Thr Leu Gln Gly Met Asn Gly Cys Asp Met Gly Pro Asp Gly 
        115                 120                 125             


Arg Leu Leu Arg Gly Tyr His Gln His Ala Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Ile Ser Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Val 
145                 150                 155                 160 


Ala Gln Ile Thr Gln Arg Phe Tyr Glu Ala Glu Glu Tyr Ala Glu Glu 
                165                 170                 175     


Phe Arg Thr Tyr Leu Glu Gly Glu Cys Leu Glu Leu Leu Arg Arg Tyr 
            180                 185                 190         


Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Glu Gln Ser Pro Gln 
        195                 200                 205             


Pro Thr Ile Pro Ile Val Gly Ile Val Ala Gly Leu Val Val Leu Gly 
    210                 215                 220                 


Ala Val Val Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Lys Lys 
225                 230                 235                 240 


Ser Ser Asp Arg Asn Arg Gly Ser Tyr Ser Gln Ala Ala Val 
                245                 250                 


<210>  1124
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  1124

Met Ala Pro Arg Ser Leu Leu Leu Leu Leu Ser Gly Ala Leu Ala Leu 
1               5                   10                  15      


Thr Asp Thr Trp Ala Gly Ser His Ser Leu Arg Tyr Phe Ser Thr Ala 
            20                  25                  30          


Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Tyr Ile Ala Val Glu Tyr 
        35                  40                  45              


Val Asp Asp Thr Gln Phe Leu Arg Phe Asp Ser Asp Ala Ala Ile Pro 
    50                  55                  60                  


Arg Met Glu Pro Arg Glu Pro Trp Val Glu Gln Glu Gly Pro Gln Tyr 
65                  70                  75                  80  


Trp Glu Trp Thr Thr Gly Tyr Ala Lys Ala Asn Ala Gln Thr Asp Arg 
                85                  90                  95      


Val Ala Leu Arg Asn Leu Leu Arg Arg Tyr Asn Gln Ser Glu Ala Gly 
            100                 105                 110         


Ser His Thr Leu Gln Gly Met Asn Gly Cys Asp Met Gly Pro Asp Gly 
        115                 120                 125             


Arg Leu Leu Arg Gly Tyr His Gln His Ala Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Ile Ser Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Val 
145                 150                 155                 160 


Ala Gln Ile Thr Gln Arg Phe Tyr Glu Ala Glu Glu Tyr Ala Glu Glu 
                165                 170                 175     


Phe Arg Thr Tyr Leu Glu Gly Glu Cys Leu Glu Leu Leu Arg Arg Tyr 
            180                 185                 190         


Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro Pro Lys Ala 
        195                 200                 205             


His Val Ala His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys 
    210                 215                 220                 


Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg 
225                 230                 235                 240 


Asp Gly Glu Glu Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro 
                245                 250                 255     


Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Pro 
            260                 265                 270         


Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro 
        275                 280                 285             


Gln Pro Leu Ile Leu Arg Trp Glu Gln Ser Pro Gln Pro Thr Ile Pro 
    290                 295                 300                 


Ile Val Gly Ile Val Ala Gly Leu Val Val Leu Gly Ala Val Val Thr 
305                 310                 315                 320 


Gly Ala Val Val Ala Ala Val Met Trp Arg Lys Lys Ser Ser Asp Arg 
                325                 330                 335     


Asn Arg Gly Ser Tyr Ser Gln Ala Ala Ala Tyr Ser Val Val Ser Gly 
            340                 345                 350         


Asn Leu Met Ile Thr Trp Trp Ser Ser Leu Phe Leu Leu Gly Val Leu 
        355                 360                 365             


Phe Gln Gly Tyr Leu Gly Cys Leu Arg Ser His Ser Val Leu Gly Arg 
    370                 375                 380                 


Arg Lys Val Gly Asp Met Trp Ile Leu Phe Phe Leu Trp Leu Trp Thr 
385                 390                 395                 400 


Ser Phe Asn Thr Ala Phe Leu Ala Leu Gln Ser Leu Arg Phe Gly Phe 
                405                 410                 415     


Gly Phe Arg Arg Gly Arg Ser Phe Leu Leu Arg Ser Trp His His Leu 
            420                 425                 430         


Met Lys Arg Val Gln Ile Lys Ile Phe Asp 
        435                 440         


<210>  1125
<211>  1079
<212>  PRT
<213>  Homo sapiens

<400>  1125

Met Glu Asp Glu Ala Val Leu Asp Arg Gly Ala Ser Phe Leu Lys His 
1               5                   10                  15      


Val Cys Asp Glu Glu Glu Val Glu Gly His His Thr Ile Tyr Ile Gly 
            20                  25                  30          


Val His Val Pro Lys Ser Tyr Arg Arg Arg Arg Arg His Lys Arg Lys 
        35                  40                  45              


Thr Gly His Lys Glu Lys Lys Glu Lys Glu Arg Ile Ser Glu Asn Tyr 
    50                  55                  60                  


Ser Asp Lys Ser Asp Ile Glu Asn Ala Asp Glu Ser Ser Ser Ser Ile 
65                  70                  75                  80  


Leu Lys Pro Leu Ile Ser Pro Ala Ala Glu Arg Ile Arg Phe Ile Leu 
                85                  90                  95      


Gly Glu Glu Asp Asp Ser Pro Ala Pro Pro Gln Leu Phe Thr Glu Leu 
            100                 105                 110         


Asp Glu Leu Leu Ala Val Asp Gly Gln Glu Met Glu Trp Lys Glu Thr 
        115                 120                 125             


Ala Arg Trp Ile Lys Phe Glu Glu Lys Val Glu Gln Gly Gly Glu Arg 
    130                 135                 140                 


Trp Ser Lys Pro His Val Ala Thr Leu Ser Leu His Ser Leu Phe Glu 
145                 150                 155                 160 


Leu Arg Thr Cys Met Glu Lys Gly Ser Ile Met Leu Asp Arg Glu Ala 
                165                 170                 175     


Ser Ser Leu Pro Gln Leu Val Glu Met Ile Val Asp His Gln Ile Glu 
            180                 185                 190         


Thr Gly Leu Leu Lys Pro Glu Leu Lys Asp Lys Val Thr Tyr Thr Leu 
        195                 200                 205             


Leu Arg Lys His Arg His Gln Thr Lys Lys Ser Asn Leu Arg Ser Leu 
    210                 215                 220                 


Ala Asp Ile Gly Lys Thr Val Ser Ser Ala Ser Arg Met Phe Thr Asn 
225                 230                 235                 240 


Pro Asp Asn Gly Ser Pro Ala Met Thr His Arg Asn Leu Thr Ser Ser 
                245                 250                 255     


Ser Leu Asn Asp Ile Ser Asp Lys Pro Glu Lys Asp Gln Leu Lys Asn 
            260                 265                 270         


Lys Phe Met Lys Lys Leu Pro Arg Asp Ala Glu Ala Ser Asn Val Leu 
        275                 280                 285             


Val Gly Glu Val Asp Phe Leu Asp Thr Pro Phe Ile Ala Phe Val Arg 
    290                 295                 300                 


Leu Gln Gln Ala Val Met Leu Gly Ala Leu Thr Glu Val Pro Val Pro 
305                 310                 315                 320 


Thr Arg Phe Leu Phe Ile Leu Leu Gly Pro Lys Gly Lys Ala Lys Ser 
                325                 330                 335     


Tyr His Glu Ile Gly Arg Ala Ile Ala Thr Leu Met Ser Asp Glu Val 
            340                 345                 350         


Phe His Asp Ile Ala Tyr Lys Ala Lys Asp Arg His Asp Leu Ile Ala 
        355                 360                 365             


Gly Ile Asp Glu Phe Leu Asp Glu Val Ile Val Leu Pro Pro Gly Glu 
    370                 375                 380                 


Trp Asp Pro Ala Ile Arg Ile Glu Pro Pro Lys Ser Leu Pro Ser Ser 
385                 390                 395                 400 


Asp Lys Arg Lys Asn Met Tyr Ser Gly Gly Glu Asn Val Gln Met Asn 
                405                 410                 415     


Gly Asp Thr Pro His Asp Gly Gly His Gly Gly Gly Gly His Gly Asp 
            420                 425                 430         


Cys Glu Glu Leu Gln Arg Thr Gly Arg Phe Cys Gly Gly Leu Ile Lys 
        435                 440                 445             


Asp Ile Lys Arg Lys Ala Pro Phe Phe Ala Ser Asp Phe Tyr Asp Ala 
    450                 455                 460                 


Leu Asn Ile Gln Ala Leu Ser Ala Ile Leu Phe Ile Tyr Leu Ala Thr 
465                 470                 475                 480 


Val Thr Asn Ala Ile Thr Phe Gly Gly Leu Leu Gly Asp Ala Thr Asp 
                485                 490                 495     


Asn Met Gln Gly Val Leu Glu Ser Phe Leu Gly Thr Ala Val Ser Gly 
            500                 505                 510         


Ala Ile Phe Cys Leu Phe Ala Gly Gln Pro Leu Thr Ile Leu Ser Ser 
        515                 520                 525             


Thr Gly Pro Val Leu Val Phe Glu Arg Leu Leu Phe Asn Phe Ser Lys 
    530                 535                 540                 


Asp Asn Asn Phe Asp Tyr Leu Glu Phe Arg Leu Trp Ile Gly Leu Trp 
545                 550                 555                 560 


Ser Ala Phe Leu Cys Leu Ile Leu Val Ala Thr Asp Ala Ser Phe Leu 
                565                 570                 575     


Val Gln Tyr Phe Thr Arg Phe Thr Glu Glu Gly Phe Ser Ser Leu Ile 
            580                 585                 590         


Ser Phe Ile Phe Ile Tyr Asp Ala Phe Lys Lys Met Ile Lys Leu Ala 
        595                 600                 605             


Asp Tyr Tyr Pro Ile Asn Ser Asn Phe Lys Val Gly Tyr Asn Thr Leu 
    610                 615                 620                 


Phe Ser Cys Thr Cys Val Pro Pro Asp Pro Ala Asn Ile Ser Ile Ser 
625                 630                 635                 640 


Asn Asp Thr Thr Leu Ala Pro Glu Tyr Leu Pro Thr Met Ser Ser Thr 
                645                 650                 655     


Asp Met Tyr His Asn Thr Thr Phe Asp Trp Ala Phe Leu Ser Lys Lys 
            660                 665                 670         


Glu Cys Ser Lys Tyr Gly Gly Asn Leu Val Gly Asn Asn Cys Asn Phe 
        675                 680                 685             


Val Pro Asp Ile Thr Leu Met Ser Phe Ile Leu Phe Leu Gly Thr Tyr 
    690                 695                 700                 


Thr Ser Ser Met Ala Leu Lys Lys Phe Lys Thr Ser Pro Tyr Phe Pro 
705                 710                 715                 720 


Thr Thr Ala Arg Lys Leu Ile Ser Asp Phe Ala Ile Ile Leu Ser Ile 
                725                 730                 735     


Leu Ile Phe Cys Val Ile Asp Ala Leu Val Gly Val Asp Thr Pro Lys 
            740                 745                 750         


Leu Ile Val Pro Ser Glu Phe Lys Pro Thr Ser Pro Asn Arg Gly Trp 
        755                 760                 765             


Phe Val Pro Pro Phe Gly Glu Asn Pro Trp Trp Val Cys Leu Ala Ala 
    770                 775                 780                 


Ala Ile Pro Ala Leu Leu Val Thr Ile Leu Ile Phe Met Asp Gln Gln 
785                 790                 795                 800 


Ile Thr Ala Val Ile Val Asn Arg Lys Glu His Lys Leu Lys Lys Gly 
                805                 810                 815     


Ala Gly Tyr His Leu Asp Leu Phe Trp Val Ala Ile Leu Met Val Ile 
            820                 825                 830         


Cys Ser Leu Met Ala Leu Pro Trp Tyr Val Ala Ala Thr Val Ile Ser 
        835                 840                 845             


Ile Ala His Ile Asp Ser Leu Lys Met Glu Thr Glu Thr Ser Ala Pro 
    850                 855                 860                 


Gly Glu Gln Pro Lys Phe Leu Gly Val Arg Glu Gln Arg Val Thr Gly 
865                 870                 875                 880 


Thr Leu Val Phe Ile Leu Thr Gly Leu Ser Val Phe Met Ala Pro Ile 
                885                 890                 895     


Leu Lys Phe Ile Pro Met Pro Val Leu Tyr Gly Val Phe Leu Tyr Met 
            900                 905                 910         


Gly Val Ala Ser Leu Asn Gly Val Gln Phe Met Asp Arg Leu Lys Leu 
        915                 920                 925             


Leu Leu Met Pro Leu Lys His Gln Pro Asp Phe Ile Tyr Leu Arg His 
    930                 935                 940                 


Val Pro Leu Arg Arg Val His Leu Phe Thr Phe Leu Gln Val Leu Cys 
945                 950                 955                 960 


Leu Ala Leu Leu Trp Ile Leu Lys Ser Thr Val Ala Ala Ile Ile Phe 
                965                 970                 975     


Pro Val Met Ile Leu Ala Leu Val Ala Val Arg Lys Gly Met Asp Tyr 
            980                 985                 990         


Leu Phe Ser Gln His Asp Leu Ser  Phe Leu Asp Asp Val  Ile Pro Glu 
        995                 1000                 1005             


Lys Asp  Lys Lys Lys Lys Glu  Asp Glu Lys Lys Lys  Lys Lys Lys 
    1010                 1015                 1020             


Lys Gly  Ser Leu Asp Ser Asp  Asn Asp Asp Ser Asp  Cys Pro Tyr 
    1025                 1030                 1035             


Ser Glu  Lys Val Pro Ser Ile  Lys Ile Pro Met Asp  Ile Met Glu 
    1040                 1045                 1050             


Gln Gln  Pro Phe Leu Ser Asp  Ser Lys Pro Ser Asp  Arg Glu Arg 
    1055                 1060                 1065             


Ser Pro  Thr Phe Leu Glu Arg  His Thr Ser Cys 
    1070                 1075                 


<210>  1126
<211>  498
<212>  PRT
<213>  Homo sapiens

<400>  1126

Met Ala Thr Lys Thr Glu Leu Ser Pro Thr Ala Arg Glu Ser Lys Asn 
1               5                   10                  15      


Ala Gln Asp Met Gln Val Asp Glu Thr Leu Ile Pro Arg Lys Val Pro 
            20                  25                  30          


Ser Leu Cys Ser Ala Arg Tyr Gly Ile Ala Leu Val Leu His Phe Cys 
        35                  40                  45              


Asn Phe Thr Thr Ile Ala Gln Asn Val Ile Met Asn Ile Thr Met Val 
    50                  55                  60                  


Ala Met Val Asn Ser Thr Ser Pro Gln Ser Gln Leu Asn Asp Ser Ser 
65                  70                  75                  80  


Glu Val Leu Pro Val Asp Ser Phe Gly Gly Leu Ser Lys Ala Pro Lys 
                85                  90                  95      


Ser Leu Pro Ala Lys Ala Pro Val Tyr Asp Trp Ser Pro Gln Ile Gln 
            100                 105                 110         


Gly Ile Ile Phe Gly Ala Val Gly Tyr Gly Gly Ile Leu Thr Met Ala 
        115                 120                 125             


Pro Ser Gly Tyr Leu Ala Gly Arg Val Gly Thr Lys Arg Val Val Gly 
    130                 135                 140                 


Ile Ser Leu Phe Ala Thr Ser Phe Leu Thr Leu Cys Ile Pro Leu Ala 
145                 150                 155                 160 


Thr Asp Phe Gly Ile Val Leu Leu Ile Val Thr Arg Ile Val Gln Gly 
                165                 170                 175     


Leu Ser Gln Ser Ser Ile Leu Gly Gly Gln Phe Ala Ile Trp Glu Lys 
            180                 185                 190         


Trp Gly Pro Pro Gln Glu Arg Ser Arg Leu Cys Ser Ile Ala Leu Ser 
        195                 200                 205             


Gly Met Leu Leu Gly Cys Phe Thr Ala Ile Leu Ile Gly Gly Phe Ile 
    210                 215                 220                 


Ser Glu Thr Leu Gly Trp Pro Phe Val Phe Tyr Ile Phe Gly Gly Val 
225                 230                 235                 240 


Gly Cys Val Cys Cys Leu Leu Trp Phe Val Val Ile Tyr Asp Asp Pro 
                245                 250                 255     


Val Ser Tyr Pro Trp Ile Ser Thr Ser Glu Lys Glu Tyr Ile Ile Ser 
            260                 265                 270         


Ser Leu Lys Gln Gln Val Gly Ser Ser Lys Gln Pro Leu Pro Ile Lys 
        275                 280                 285             


Ala Met Leu Arg Ser Leu Pro Ile Trp Ser Ile Cys Leu Gly Cys Phe 
    290                 295                 300                 


Ser His Gln Trp Leu Val Ser Thr Met Val Val Tyr Ile Pro Thr Tyr 
305                 310                 315                 320 


Ile Ser Ser Val Tyr His Val Asn Ile Arg Asp Asn Gly Leu Leu Ser 
                325                 330                 335     


Ala Leu Pro Phe Ile Val Ala Trp Val Ile Gly Met Val Gly Gly Tyr 
            340                 345                 350         


Leu Ala Asp Phe Leu Leu Thr Lys Lys Phe Arg Leu Ile Thr Val Arg 
        355                 360                 365             


Lys Ile Ala Thr Ile Leu Gly Ser Leu Pro Ser Ser Ala Leu Ile Val 
    370                 375                 380                 


Ser Leu Pro Tyr Leu Asn Ser Gly Tyr Ile Thr Ala Thr Ala Leu Leu 
385                 390                 395                 400 


Thr Leu Ser Cys Gly Leu Ser Thr Leu Cys Gln Ser Gly Ile Tyr Ile 
                405                 410                 415     


Asn Val Leu Asp Ile Ala Pro Arg Tyr Ser Ser Phe Leu Met Gly Ala 
            420                 425                 430         


Ser Arg Gly Phe Ser Ser Ile Ala Pro Val Ile Val Pro Thr Val Ser 
        435                 440                 445             


Gly Phe Leu Leu Ser Gln Asp Pro Glu Phe Gly Trp Arg Asn Val Phe 
    450                 455                 460                 


Phe Leu Leu Phe Ala Val Asn Leu Leu Gly Leu Leu Phe Tyr Leu Ile 
465                 470                 475                 480 


Phe Gly Glu Ala Asp Val Gln Glu Trp Ala Lys Glu Arg Lys Leu Thr 
                485                 490                 495     


Arg Leu 
        


<210>  1127
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  1127

Met Lys Pro Ala Ala Arg Glu Ala Arg Leu Pro Pro Arg Ser Pro Gly 
1               5                   10                  15      


Leu Arg Trp Ala Leu Pro Leu Leu Leu Leu Leu Leu Arg Leu Gly Gln 
            20                  25                  30          


Ile Leu Cys Ala Gly Gly Thr Pro Ser Pro Ile Pro Asp Pro Ser Val 
        35                  40                  45              


Ala Thr Val Ala Thr Gly Glu Asn Gly Ile Thr Gln Ile Ser Ser Thr 
    50                  55                  60                  


Ala Glu Ser Phe His Lys Gln Asn Gly Thr Gly Thr Pro Gln Val Glu 
65                  70                  75                  80  


Thr Asn Thr Ser Glu Asp Gly Glu Ser Ser Gly Ala Asn Asp Ser Leu 
                85                  90                  95      


Arg Thr Pro Glu Gln Gly Ser Asn Gly Thr Asp Gly Ala Ser Gln Lys 
            100                 105                 110         


Thr Pro Ser Ser Thr Gly Pro Ser Pro Val Phe Asp Ile Lys Ala Val 
        115                 120                 125             


Ser Ile Ser Pro Thr Asn Val Ile Leu Thr Trp Lys Ser Asn Asp Thr 
    130                 135                 140                 


Ala Ala Ser Glu Tyr Lys Tyr Val Val Lys His Lys Met Glu Asn Glu 
145                 150                 155                 160 


Lys Thr Ile Thr Val Val His Gln Pro Trp Cys Asn Ile Thr Gly Leu 
                165                 170                 175     


Arg Pro Ala Thr Ser Tyr Val Phe Ser Ile Thr Pro Gly Ile Gly Asn 
            180                 185                 190         


Glu Thr Trp Gly Asp Pro Arg Val Ile Lys Val Ile Thr Glu Pro Ile 
        195                 200                 205             


Pro Val Ser Asp Leu Arg Val Ala Leu Thr Gly Val Arg Lys Ala Ala 
    210                 215                 220                 


Leu Ser Trp Ser Asn Gly Asn Gly Thr Ala Ser Cys Arg Val Leu Leu 
225                 230                 235                 240 


Glu Ser Ile Gly Ser His Glu Glu Leu Thr Gln Asp Ser Arg Leu Gln 
                245                 250                 255     


Val Asn Ile Ser Gly Leu Lys Pro Gly Val Gln Tyr Asn Ile Asn Pro 
            260                 265                 270         


Tyr Leu Leu Gln Ser Asn Lys Thr Lys Gly Asp Pro Leu Gly Thr Glu 
        275                 280                 285             


Gly Gly Leu Asp Ala Ser Asn Thr Glu Arg Ser Arg Ala Gly Ser Pro 
    290                 295                 300                 


Thr Ala Pro Val His Asp Glu Ser Leu Val Gly Pro Val Asp Pro Ser 
305                 310                 315                 320 


Ser Gly Gln Gln Ser Arg Asp Thr Glu Val Leu Leu Val Gly Leu Glu 
                325                 330                 335     


Pro Gly Thr Arg Tyr Asn Ala Thr Val Tyr Ser Gln Ala Ala Asn Gly 
            340                 345                 350         


Thr Glu Gly Gln Pro Gln Ala Ile Glu Phe Arg Thr Asn Ala Ile Gln 
        355                 360                 365             


Val Phe Asp Val Thr Ala Val Asn Ile Ser Ala Thr Ser Leu Thr Leu 
    370                 375                 380                 


Ile Trp Lys Val Ser Asp Asn Glu Ser Ser Ser Asn Tyr Thr Tyr Lys 
385                 390                 395                 400 


Ile His Val Ala Gly Glu Thr Asp Ser Ser Asn Leu Asn Val Ser Glu 
                405                 410                 415     


Pro Arg Ala Val Ile Pro Gly Leu Arg Ser Ser Thr Phe Tyr Asn Ile 
            420                 425                 430         


Thr Val Cys Pro Val Leu Gly Asp Ile Glu Gly Thr Pro Gly Phe Leu 
        435                 440                 445             


Gln Val His Thr Pro Pro Val Pro Val Ser Asp Phe Arg Val Thr Val 
    450                 455                 460                 


Val Ser Thr Thr Glu Ile Gly Leu Ala Trp Ser Ser His Asp Ala Glu 
465                 470                 475                 480 


Ser Phe Gln Met His Ile Thr Gln Glu Gly Ala Gly Asn Ser Arg Val 
                485                 490                 495     


Glu Ile Thr Thr Asn Gln Ser Ile Ile Ile Gly Gly Leu Phe Pro Gly 
            500                 505                 510         


Thr Lys Tyr Cys Phe Glu Ile Val Pro Lys Gly Pro Asn Gly Thr Glu 
        515                 520                 525             


Gly Ala Ser Arg Thr Val Cys Asn Arg Thr Gly 
    530                 535                 


<210>  1128
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  1128

Met Gly Pro Pro Ser Ala Cys Pro His Arg Glu Cys Ile Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Ala Pro Thr 
            20                  25                  30          


Thr Ala Trp Leu Phe Ile Ala Ser Ala Pro Phe Glu Val Ala Glu Gly 
        35                  40                  45              


Glu Asn Val His Leu Ser Val Val Tyr Leu Pro Glu Asn Leu Tyr Ser 
    50                  55                  60                  


Tyr Gly Trp Tyr Lys Gly Lys Thr Val Glu Pro Asn Gln Leu Ile Ala 
65                  70                  75                  80  


Ala Tyr Val Ile Asp Thr His Val Arg Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Ser Pro Ser Gly Asp Leu His Phe Gln Asn Val 
            100                 105                 110         


Thr Leu Glu Asp Thr Gly Tyr Tyr Asn Leu Gln Val Thr Tyr Arg Asn 
        115                 120                 125             


Ser Gln Ile Glu Gln Ala Ser His His Leu Arg Val Tyr Glu Ser Val 
    130                 135                 140                 


Ala Gln Pro Ser Ile Gln Ala Ser Ser Thr Thr Val Thr Glu Lys Gly 
145                 150                 155                 160 


Ser Val Val Leu Thr Cys His Thr Asn Asn Thr Gly Thr Ser Phe Gln 
                165                 170                 175     


Trp Ile Phe Asn Asn Gln Arg Leu Gln Val Thr Lys Arg Met Lys Leu 
            180                 185                 190         


Ser Trp Phe Asn His Val Leu Thr Ile Asp Pro Ile Arg Gln Glu Asp 
        195                 200                 205             


Ala Gly Glu Tyr Gln Cys Glu Val Ser Asn Pro Val Ser Ser Asn Arg 
    210                 215                 220                 


Ser Asp Pro Leu Lys Leu Thr Val Lys Ser Asp Asp Asn Thr Leu Gly 
225                 230                 235                 240 


Ile Leu Ile Gly Val Leu Val Gly Ser Leu Leu Val Ala Ala Leu Val 
                245                 250                 255     


Cys Phe Leu Leu Leu Arg Lys Thr Gly Arg Ala Ser Asp Gln Ser Asp 
            260                 265                 270         


Phe Arg Glu Gln Gln Pro Pro Ala Ser Thr Pro Gly His Gly Pro Ser 
        275                 280                 285             


Asp Ser Ser Ile Ser 
    290             


<210>  1129
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  1129

Met Ala Gly Asn Cys Ser Trp Glu Ala His Pro Gly Asn Arg Asn Lys 
1               5                   10                  15      


Met Cys Pro Gly Leu Ser Glu Ala Pro Glu Leu Tyr Ser Arg Gly Phe 
            20                  25                  30          


Leu Thr Ile Glu Gln Ile Ala Met Leu Pro Pro Pro Ala Val Met Asn 
        35                  40                  45              


Tyr Ile Phe Leu Leu Leu Cys Leu Cys Gly Leu Val Gly Asn Gly Leu 
    50                  55                  60                  


Val Leu Trp Phe Phe Gly Phe Ser Ile Lys Arg Asn Pro Phe Ser Ile 
65                  70                  75                  80  


Tyr Phe Leu His Leu Ala Ser Ala Asp Val Gly Tyr Leu Phe Ser Lys 
                85                  90                  95      


Ala Val Phe Ser Ile Leu Asn Thr Gly Gly Phe Leu Gly Thr Phe Ala 
            100                 105                 110         


Asp Tyr Ile Arg Ser Val Cys Arg Val Leu Gly Leu Cys Met Phe Leu 
        115                 120                 125             


Thr Gly Val Ser Leu Leu Pro Ala Val Ser Ala Glu Arg Cys Ala Ser 
    130                 135                 140                 


Val Ile Phe Pro Ala Trp Tyr Trp Arg Arg Arg Pro Lys Arg Leu Ser 
145                 150                 155                 160 


Ala Val Val Cys Ala Leu Leu Trp Val Leu Ser Leu Leu Val Thr Cys 
                165                 170                 175     


Leu His Asn Tyr Phe Cys Val Phe Leu Gly Arg Gly Ala Pro Gly Ala 
            180                 185                 190         


Ala Cys Arg His Met Asp Ile Phe Leu Gly Ile Leu Leu Phe Leu Leu 
        195                 200                 205             


Cys Cys Pro Leu Met Val Leu Pro Cys Leu Ala Leu Ile Leu His Val 
    210                 215                 220                 


Glu Cys Arg Ala Arg Arg Arg Gln Arg Ser Ala Lys Leu Asn His Val 
225                 230                 235                 240 


Ile Leu Ala Met Val Ser Val Phe Leu Val Ser Ser Ile Tyr Leu Gly 
                245                 250                 255     


Ile Asp Trp Phe Leu Phe Trp Val Phe Gln Ile Pro Ala Pro Phe Pro 
            260                 265                 270         


Glu Tyr Val Thr Asp Leu Cys Ile Cys Ile Asn Ser Ser Ala Lys Pro 
        275                 280                 285             


Ile Val Tyr Phe Leu Ala Gly Arg Asp Lys Ser Gln Arg Leu Trp Glu 
    290                 295                 300                 


Pro Leu Arg Val Val Phe Gln Arg Ala Leu Arg Asp Gly Ala Glu Leu 
305                 310                 315                 320 


Gly Glu Ala Gly Gly Ser Thr Pro Asn Thr Val Thr Met Glu Met Gln 
                325                 330                 335     


Cys Pro Pro Gly Asn Ala Ser 
            340             


<210>  1130
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  1130

Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln Cys Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu Leu Leu Leu Leu 
            20                  25                  30          


Phe Ser Ala Ala Ala Leu Ile Pro Thr Gly Asp Gly Gln Asn Leu Phe 
        35                  40                  45              


Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val Ala Thr Ile Ser Cys 
    50                  55                  60                  


Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln Leu Leu Asn Pro Asn 
65                  70                  75                  80  


Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro Leu Lys Asp Ser Arg 
                85                  90                  95      


Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys Val Ser Leu Thr 
            100                 105                 110         


Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe Cys Gln Leu Tyr Thr 
        115                 120                 125             


Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr Val Leu Val Pro Pro 
    130                 135                 140                 


Arg Asn Leu Met Ile Asp Ile Gln Lys Asp Thr Ala Val Glu Gly Glu 
145                 150                 155                 160 


Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala Thr Thr 
                165                 170                 175     


Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys Gly Lys Ser Glu Val 
            180                 185                 190         


Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln Leu Met Leu Lys 
        195                 200                 205             


Val His Lys Glu Asp Asp Gly Val Pro Val Ile Cys Gln Val Glu His 
    210                 215                 220                 


Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr Leu Glu Val Gln 
225                 230                 235                 240 


Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro Leu Gln Gly Leu 
                245                 250                 255     


Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu Ala Ile Gly Lys 
            260                 265                 270         


Pro Gln Pro Val Met Val Thr Trp Val Arg Val Asp Asp Glu Met Pro 
        275                 280                 285             


Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe Ile Asn Asn Leu Asn 
    290                 295                 300                 


Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser Asn Ile Val Gly 
305                 310                 315                 320 


Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr Asp Ser Arg Ala Gly 
                325                 330                 335     


Glu Glu Gly Ser Ile Arg Ala Val Asp His Ala Val Ile Gly Gly Val 
            340                 345                 350         


Val Ala Val Val Val Phe Ala Met Leu Cys Leu Leu Ile Ile Leu Gly 
        355                 360                 365             


Arg Tyr Phe Ala Arg His Lys Gly Thr Tyr Phe Thr His Glu Ala Lys 
    370                 375                 380                 


Gly Ala Asp Asp Ala Ala Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu 
385                 390                 395                 400 


Gly Gly Gln Asn Asn Ser Glu Glu Lys Lys Glu Tyr Phe Ile 
                405                 410                 


<210>  1131
<211>  1346
<212>  PRT
<213>  Homo sapiens

<400>  1131

Met Lys Ser Pro Arg Arg Thr Thr Leu Cys Leu Met Phe Ile Val Ile 
1               5                   10                  15      


Tyr Ser Ser Lys Ala Ala Leu Asn Trp Asn Tyr Glu Ser Thr Ile His 
            20                  25                  30          


Pro Leu Ser Leu His Glu His Glu Pro Ala Gly Glu Glu Ala Leu Arg 
        35                  40                  45              


Gln Lys Arg Ala Val Ala Thr Lys Ser Pro Thr Ala Glu Glu Tyr Thr 
    50                  55                  60                  


Val Asn Ile Glu Ile Ser Phe Glu Asn Ala Ser Phe Leu Asp Pro Ile 
65                  70                  75                  80  


Lys Ala Tyr Leu Asn Ser Leu Ser Phe Pro Ile His Gly Asn Asn Thr 
                85                  90                  95      


Asp Gln Ile Thr Asp Ile Leu Ser Ile Asn Val Thr Thr Val Cys Arg 
            100                 105                 110         


Pro Ala Gly Asn Glu Ile Trp Cys Ser Cys Glu Thr Gly Tyr Gly Trp 
        115                 120                 125             


Pro Arg Glu Arg Cys Leu His Asn Leu Ile Cys Gln Glu Arg Asp Val 
    130                 135                 140                 


Phe Leu Pro Gly His His Cys Ser Cys Leu Lys Glu Leu Pro Pro Asn 
145                 150                 155                 160 


Gly Pro Phe Cys Leu Leu Gln Glu Asp Val Thr Leu Asn Met Arg Val 
                165                 170                 175     


Arg Leu Asn Val Gly Phe Gln Glu Asp Leu Met Asn Thr Ser Ser Ala 
            180                 185                 190         


Leu Tyr Arg Ser Tyr Lys Thr Asp Leu Glu Thr Ala Phe Arg Lys Gly 
        195                 200                 205             


Tyr Gly Ile Leu Pro Gly Phe Lys Gly Val Thr Val Thr Gly Phe Lys 
    210                 215                 220                 


Ser Gly Ser Val Val Val Thr Tyr Glu Val Lys Thr Thr Pro Pro Ser 
225                 230                 235                 240 


Leu Glu Leu Ile His Lys Ala Asn Glu Gln Val Val Gln Ser Leu Asn 
                245                 250                 255     


Gln Thr Tyr Lys Met Asp Tyr Asn Ser Phe Gln Ala Val Thr Ile Asn 
            260                 265                 270         


Glu Ser Asn Phe Phe Val Thr Pro Glu Ile Ile Phe Glu Gly Asp Thr 
        275                 280                 285             


Val Ser Leu Val Cys Glu Lys Glu Val Leu Ser Ser Asn Val Ser Trp 
    290                 295                 300                 


Arg Tyr Glu Glu Gln Gln Leu Glu Ile Gln Asn Ser Ser Arg Phe Ser 
305                 310                 315                 320 


Ile Tyr Thr Ala Leu Phe Asn Asn Met Thr Ser Val Ser Lys Leu Thr 
                325                 330                 335     


Ile His Asn Ile Thr Pro Gly Asp Ala Gly Glu Tyr Val Cys Lys Leu 
            340                 345                 350         


Ile Leu Asp Ile Phe Glu Tyr Glu Cys Lys Lys Lys Ile Asp Val Met 
        355                 360                 365             


Pro Ile Gln Ile Leu Ala Asn Glu Glu Met Lys Val Met Cys Asp Asn 
    370                 375                 380                 


Asn Pro Val Ser Leu Asn Cys Cys Ser Gln Gly Asn Val Asn Trp Ser 
385                 390                 395                 400 


Lys Val Glu Trp Lys Gln Glu Gly Lys Ile Asn Ile Pro Gly Thr Pro 
                405                 410                 415     


Glu Thr Asp Ile Asp Ser Ser Cys Ser Arg Tyr Thr Leu Lys Ala Asp 
            420                 425                 430         


Gly Thr Gln Cys Pro Ser Gly Ser Ser Gly Thr Thr Val Ile Tyr Thr 
        435                 440                 445             


Cys Glu Phe Ile Ser Ala Tyr Gly Ala Arg Gly Ser Ala Asn Ile Lys 
    450                 455                 460                 


Val Thr Phe Ile Ser Val Ala Asn Leu Thr Ile Thr Pro Asp Pro Ile 
465                 470                 475                 480 


Ser Val Ser Glu Gly Gln Asn Phe Ser Ile Lys Cys Ile Ser Asp Val 
                485                 490                 495     


Ser Asn Tyr Asp Glu Val Tyr Trp Asn Thr Ser Ala Gly Ile Lys Ile 
            500                 505                 510         


Tyr Gln Arg Phe Tyr Thr Thr Arg Arg Tyr Leu Asp Gly Ala Glu Ser 
        515                 520                 525             


Val Leu Thr Val Lys Thr Ser Thr Arg Glu Trp Asn Gly Thr Tyr His 
    530                 535                 540                 


Cys Ile Phe Arg Tyr Lys Asn Ser Tyr Ser Ile Ala Thr Lys Asp Val 
545                 550                 555                 560 


Ile Val His Pro Leu Pro Leu Lys Leu Asn Ile Met Val Asp Pro Leu 
                565                 570                 575     


Glu Ala Thr Val Ser Cys Ser Gly Ser His His Ile Lys Cys Cys Ile 
            580                 585                 590         


Glu Glu Asp Gly Asp Tyr Lys Val Thr Phe His Thr Gly Ser Ser Ser 
        595                 600                 605             


Leu Pro Ala Ala Lys Glu Val Asn Lys Lys Gln Val Cys Tyr Lys His 
    610                 615                 620                 


Asn Phe Asn Ala Ser Ser Val Ser Trp Cys Ser Lys Thr Val Asp Val 
625                 630                 635                 640 


Cys Cys His Phe Thr Asn Ala Ala Asn Asn Ser Val Trp Ser Pro Ser 
                645                 650                 655     


Met Lys Leu Asn Leu Val Pro Gly Glu Asn Ile Thr Cys Gln Asp Pro 
            660                 665                 670         


Val Ile Gly Val Gly Glu Pro Gly Lys Val Ile Gln Lys Leu Cys Arg 
        675                 680                 685             


Phe Ser Asn Val Pro Ser Ser Pro Glu Ser Pro Ile Gly Gly Thr Ile 
    690                 695                 700                 


Thr Tyr Lys Cys Val Gly Ser Gln Trp Glu Glu Lys Arg Asn Asp Cys 
705                 710                 715                 720 


Ile Ser Ala Pro Ile Asn Ser Leu Leu Gln Met Ala Lys Ala Leu Ile 
                725                 730                 735     


Lys Ser Pro Ser Gln Asp Glu Met Leu Pro Thr Tyr Leu Lys Asp Leu 
            740                 745                 750         


Ser Ile Ser Ile Asp Lys Ala Glu His Glu Ile Ser Ser Ser Pro Gly 
        755                 760                 765             


Ser Leu Gly Ala Ile Ile Asn Ile Leu Asp Leu Leu Ser Thr Val Pro 
    770                 775                 780                 


Thr Gln Val Asn Ser Glu Met Met Thr His Val Leu Ser Thr Val Asn 
785                 790                 795                 800 


Val Ile Leu Gly Lys Pro Val Leu Asn Thr Trp Lys Val Leu Gln Gln 
                805                 810                 815     


Gln Trp Thr Asn Gln Ser Ser Gln Leu Leu His Ser Val Glu Arg Phe 
            820                 825                 830         


Ser Gln Ala Leu Gln Ser Gly Asp Ser Pro Pro Leu Ser Phe Ser Gln 
        835                 840                 845             


Thr Asn Val Gln Met Ser Ser Met Val Ile Lys Ser Ser His Pro Glu 
    850                 855                 860                 


Thr Tyr Gln Gln Arg Phe Val Phe Pro Tyr Phe Asp Leu Trp Gly Asn 
865                 870                 875                 880 


Val Val Ile Asp Lys Ser Tyr Leu Glu Asn Leu Gln Ser Asp Ser Ser 
                885                 890                 895     


Ile Val Thr Met Ala Phe Pro Thr Leu Gln Ala Ile Leu Ala Gln Asp 
            900                 905                 910         


Ile Gln Glu Asn Asn Phe Ala Glu Ser Leu Val Met Thr Thr Thr Val 
        915                 920                 925             


Ser His Asn Thr Thr Met Pro Phe Arg Ile Ser Met Thr Phe Lys Asn 
    930                 935                 940                 


Asn Ser Pro Ser Gly Gly Glu Thr Lys Cys Val Phe Trp Asn Phe Arg 
945                 950                 955                 960 


Leu Ala Asn Asn Thr Gly Gly Trp Asp Ser Ser Gly Cys Tyr Val Glu 
                965                 970                 975     


Glu Gly Asp Gly Asp Asn Val Thr Cys Ile Cys Asp His Leu Thr Ser 
            980                 985                 990         


Phe Ser Ile Leu Met Ser Pro Asp  Ser Pro Asp Pro Ser  Ser Leu Leu 
        995                 1000                 1005             


Gly Ile  Leu Leu Asp Ile Ile  Ser Tyr Val Gly Val  Gly Phe Ser 
    1010                 1015                 1020             


Ile Leu  Ser Leu Ala Ala Cys  Leu Val Val Glu Ala  Val Val Trp 
    1025                 1030                 1035             


Lys Ser  Val Thr Lys Asn Arg  Thr Ser Tyr Met Arg  His Thr Cys 
    1040                 1045                 1050             


Ile Val  Asn Ile Ala Ala Ser  Leu Leu Val Ala Asn  Thr Trp Phe 
    1055                 1060                 1065             


Ile Val  Val Ala Ala Ile Gln  Asp Asn Arg Tyr Ile  Leu Cys Lys 
    1070                 1075                 1080             


Thr Ala  Cys Val Ala Ala Thr  Phe Phe Ile His Phe  Phe Tyr Leu 
    1085                 1090                 1095             


Ser Val  Phe Phe Trp Met Leu  Thr Leu Gly Leu Met  Leu Phe Tyr 
    1100                 1105                 1110             


Arg Leu  Val Phe Ile Leu His  Glu Thr Ser Arg Ser  Thr Gln Lys 
    1115                 1120                 1125             


Ala Ile  Ala Phe Cys Leu Gly  Tyr Gly Cys Pro Leu  Ala Ile Ser 
    1130                 1135                 1140             


Val Ile  Thr Leu Gly Ala Thr  Gln Pro Arg Glu Val  Tyr Thr Arg 
    1145                 1150                 1155             


Lys Asn  Val Cys Trp Leu Asn  Trp Glu Asp Thr Lys  Ala Leu Leu 
    1160                 1165                 1170             


Ala Phe  Ala Ile Pro Ala Leu  Ile Ile Val Val Val  Asn Ile Thr 
    1175                 1180                 1185             


Ile Thr  Ile Val Val Ile Thr  Lys Ile Leu Arg Pro  Ser Ile Gly 
    1190                 1195                 1200             


Asp Lys  Pro Cys Lys Gln Glu  Lys Ser Ser Leu Phe  Gln Ile Ser 
    1205                 1210                 1215             


Lys Ser  Ile Gly Val Leu Thr  Pro Leu Leu Gly Leu  Thr Trp Gly 
    1220                 1225                 1230             


Phe Gly  Leu Thr Thr Val Phe  Pro Gly Thr Asn Leu  Val Phe His 
    1235                 1240                 1245             


Ile Ile  Phe Ala Ile Leu Asn  Val Phe Gln Gly Leu  Phe Ile Leu 
    1250                 1255                 1260             


Leu Phe  Gly Cys Leu Trp Asp  Leu Lys Val Gln Glu  Ala Leu Leu 
    1265                 1270                 1275             


Asn Lys  Phe Ser Leu Ser Arg  Trp Ser Ser Gln His  Ser Lys Ser 
    1280                 1285                 1290             


Thr Ser  Leu Gly Ser Ser Thr  Pro Val Phe Ser Met  Ser Ser Pro 
    1295                 1300                 1305             


Ile Ser  Arg Arg Phe Asn Asn  Leu Phe Gly Lys Thr  Gly Thr Tyr 
    1310                 1315                 1320             


Asn Val  Ser Thr Pro Glu Ala  Thr Ser Ser Ser Leu  Glu Asn Ser 
    1325                 1330                 1335             


Ser Ser  Ala Ser Ser Leu Leu  Asn 
    1340                 1345     


<210>  1132
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  1132

Met Ala Gly Pro Ala Ala Leu Ser Ala Ala Ala Ala Ala Ala Leu Ala 
1               5                   10                  15      


Ala Ala Leu Leu Leu Leu Arg Arg Glu Asp Pro Gly Pro Gly Ala Gly 
            20                  25                  30          


Pro Ser Met Ala Glu Thr Glu Ala Leu Ser Lys Leu Arg Glu Asp Phe 
        35                  40                  45              


Arg Met Gln Asn Lys Ser Val Phe Ile Leu Gly Ala Ser Gly Glu Thr 
    50                  55                  60                  


Gly Arg Val Leu Leu Lys Glu Ile Leu Glu Gln Gly Leu Phe Ser Lys 
65                  70                  75                  80  


Val Thr Leu Ile Gly Arg Arg Lys Leu Thr Phe Asp Glu Glu Ala Tyr 
                85                  90                  95      


Lys Asn Val Asn Gln Glu Val Val Asp Phe Glu Lys Leu Asp Asp Tyr 
            100                 105                 110         


Ala Ser Ala Phe Gln Gly His Asp Val Gly Phe Cys Cys Leu Gly Thr 
        115                 120                 125             


Thr Arg Gly Lys Ala Gly Ala Glu Gly Phe Val Arg Val Asp Arg Asp 
    130                 135                 140                 


Tyr Val Leu Lys Ser Ala Glu Leu Ala Lys Ala Gly Gly Cys Lys His 
145                 150                 155                 160 


Phe Asn Leu Leu Ser Ser Lys Gly Ala Asp Lys Ser Ser Asn Phe Leu 
                165                 170                 175     


Tyr Leu Gln Val Lys Gly Glu Val Glu Ala Lys Val Glu Glu Leu Lys 
            180                 185                 190         


Phe Asp Arg Tyr Ser Val Phe Arg Pro Gly Val Leu Leu Cys Asp Arg 
        195                 200                 205             


Gln Glu Ser Arg Pro Gly Glu Trp Leu Val Arg Lys Phe Phe Gly Ser 
    210                 215                 220                 


Leu Pro Asp Ser Trp Ala Ser Gly His Ser Val Pro Val Val Thr Val 
225                 230                 235                 240 


Val Arg Ala Met Leu Asn Asn Val Val Arg Pro Arg Asp Lys Gln Met 
                245                 250                 255     


Glu Leu Leu Glu Asn Lys Ala Ile His Asp Leu Gly Lys Ala His Gly 
            260                 265                 270         


Ser Leu Lys Pro 
        275     


<210>  1133
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  1133

Met Ala Glu Thr Glu Ala Leu Ser Lys Leu Arg Glu Asp Phe Arg Met 
1               5                   10                  15      


Gln Asn Lys Ser Val Phe Ile Leu Gly Ala Ser Gly Glu Thr Gly Arg 
            20                  25                  30          


Val Leu Leu Lys Glu Ile Leu Glu Gln Gly Leu Phe Ser Lys Val Thr 
        35                  40                  45              


Leu Ile Gly Arg Arg Lys Leu Thr Phe Asp Glu Glu Ala Tyr Lys Asn 
    50                  55                  60                  


Val Asn Gln Glu Val Val Asp Phe Glu Lys Leu Asp Asp Tyr Ala Ser 
65                  70                  75                  80  


Ala Phe Gln Gly His Asp Val Gly Phe Cys Cys Leu Gly Thr Thr Arg 
                85                  90                  95      


Gly Lys Ala Gly Ala Glu Gly Phe Val Arg Val Asp Arg Asp Tyr Val 
            100                 105                 110         


Leu Lys Ser Ala Glu Leu Ala Lys Ala Gly Gly Cys Lys His Phe Asn 
        115                 120                 125             


Leu Leu Ser Ser Lys Gly Ala Asp Lys Ser Ser Asn Phe Leu Tyr Leu 
    130                 135                 140                 


Gln Val Lys Gly Glu Val Glu Ala Lys Val Glu Glu Leu Lys Phe Asp 
145                 150                 155                 160 


Arg Tyr Ser Val Phe Arg Pro Gly Val Leu Leu Cys Asp Arg Gln Glu 
                165                 170                 175     


Ser Arg Pro Gly Glu Trp Leu Val Arg Lys Phe Phe Gly Ser Leu Pro 
            180                 185                 190         


Asp Ser Trp Ala Ser Gly His Ser Val Pro Val Val Thr Val Val Arg 
        195                 200                 205             


Ala Met Leu Asn Asn Val Val Arg Pro Arg Asp Lys Gln Met Glu Leu 
    210                 215                 220                 


Leu Glu Asn Lys Ala Ile His Asp Leu Gly Lys Ala His Gly Ser Leu 
225                 230                 235                 240 


Lys Pro 
        


<210>  1134
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  1134

Met Ala Glu Thr Glu Ala Leu Ser Lys Leu Arg Glu Asp Phe Arg Met 
1               5                   10                  15      


Gln Asn Lys Ser Val Phe Ile Leu Gly Ala Ser Gly Glu Thr Gly Arg 
            20                  25                  30          


Val Leu Leu Lys Glu Ile Leu Glu Gln Gly Leu Phe Ser Lys Val Thr 
        35                  40                  45              


Leu Ile Gly Arg Arg Lys Leu Thr Phe Asp Glu Glu Ala Tyr Lys Asn 
    50                  55                  60                  


Val Asn Gln Glu Val Val Asp Phe Glu Lys Leu Asp Asp Tyr Ala Ser 
65                  70                  75                  80  


Ala Phe Gln Gly His Asp Val Gly Phe Cys Cys Leu Gly Thr Thr Arg 
                85                  90                  95      


Gly Lys Ala Gly Ala Glu Gly Phe Val Arg Val Asp Arg Asp Tyr Val 
            100                 105                 110         


Leu Lys Ser Ala Glu Leu Ala Lys Ala Gly Gly Cys Lys His Phe Asn 
        115                 120                 125             


Leu Leu Ser Ser Lys Gly Ala Asp Lys Ser Ser Asn Phe Leu Tyr Leu 
    130                 135                 140                 


Gln Val Lys Gly Glu Val Glu Ala Lys Val Glu Glu Leu Lys Phe Asp 
145                 150                 155                 160 


Arg Tyr Ser Val Phe Arg Pro Gly Val Leu Leu Cys Asp Arg Gln Glu 
                165                 170                 175     


Ser Arg Pro Gly Glu Trp Leu Val Arg Lys Phe Phe Gly Ser Leu Pro 
            180                 185                 190         


Asp Ser Trp Ala Ser Gly His Ser Val Pro Val Val Thr Val Val Arg 
        195                 200                 205             


Ala Met Leu Asn Asn Val Val Arg Pro Arg Asp Lys Gln Met Glu Leu 
    210                 215                 220                 


Leu Glu Asn Lys Ala Ile His Asp Leu Gly Lys Ala His Gly Ser Leu 
225                 230                 235                 240 


Lys Pro 
        


<210>  1135
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  1135

Met Ala Glu Thr Glu Ala Leu Ser Lys Leu Arg Glu Asp Phe Arg Met 
1               5                   10                  15      


Gln Asn Lys Ser Val Phe Ile Leu Gly Ala Ser Gly Glu Thr Gly Arg 
            20                  25                  30          


Val Leu Leu Lys Glu Ile Leu Glu Gln Gly Leu Phe Ser Lys Val Thr 
        35                  40                  45              


Leu Ile Gly Arg Arg Lys Leu Thr Phe Asp Glu Glu Ala Tyr Lys Asn 
    50                  55                  60                  


Val Asn Gln Glu Val Val Asp Phe Glu Lys Leu Asp Asp Tyr Ala Ser 
65                  70                  75                  80  


Ala Phe Gln Gly His Asp Val Gly Phe Cys Cys Leu Gly Thr Thr Arg 
                85                  90                  95      


Gly Lys Ala Gly Ala Val Arg Lys Ala Tyr Ala Leu Phe Pro Phe Cys 
            100                 105                 110         


Trp Pro Val Ile Ser Arg Ile Leu Phe Leu Leu Thr Leu Phe Leu Cys 
        115                 120                 125             


Ala Cys Cys Asn Ala 
    130             


<210>  1136
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  1136

Met Phe Cys Pro Leu Lys Leu Ile Leu Leu Pro Val Leu Leu Asp Tyr 
1               5                   10                  15      


Ser Leu Gly Leu Asn Asp Leu Asn Val Ser Pro Pro Glu Leu Thr Val 
            20                  25                  30          


His Val Gly Asp Ser Ala Leu Met Gly Cys Val Phe Gln Ser Thr Glu 
        35                  40                  45              


Asp Lys Cys Ile Phe Lys Ile Asp Trp Thr Leu Ser Pro Gly Glu His 
    50                  55                  60                  


Ala Lys Asp Glu Tyr Val Leu Tyr Tyr Tyr Ser Asn Leu Ser Val Pro 
65                  70                  75                  80  


Ile Gly Arg Phe Gln Asn Arg Val His Leu Met Gly Asp Ile Leu Cys 
                85                  90                  95      


Asn Asp Gly Ser Leu Leu Leu Gln Asp Val Gln Glu Ala Asp Gln Gly 
            100                 105                 110         


Thr Tyr Ile Cys Glu Ile Arg Leu Lys Gly Glu Ser Gln Val Phe Lys 
        115                 120                 125             


Lys Ala Val Val Leu His Val Leu Pro Glu Glu Pro Lys Glu Leu Met 
    130                 135                 140                 


Val His Val Gly Gly Leu Ile Gln Met Gly Cys Val Phe Gln Ser Thr 
145                 150                 155                 160 


Glu Val Lys His Val Thr Lys Val Glu Trp Ile Phe Ser Gly Arg Arg 
                165                 170                 175     


Ala Lys Glu Glu Ile Val Phe Arg Tyr Tyr His Lys Leu Arg Met Ser 
            180                 185                 190         


Val Glu Tyr Ser Gln Ser Trp Gly His Phe Gln Asn Arg Val Asn Leu 
        195                 200                 205             


Val Gly Asp Ile Phe Arg Asn Asp Gly Ser Ile Met Leu Gln Gly Val 
    210                 215                 220                 


Arg Glu Ser Asp Gly Gly Asn Tyr Thr Cys Ser Ile His Leu Gly Asn 
225                 230                 235                 240 


Leu Val Phe Lys Lys Thr Ile Val Leu His Val Ser Pro Glu Glu Pro 
                245                 250                 255     


Arg Thr Leu Val Thr Pro Ala Ala Leu Arg Pro Leu Val Leu Gly Gly 
            260                 265                 270         


Asn Gln Leu Val Ile Ile Val Gly Ile Val Cys Ala Thr Ile Leu Leu 
        275                 280                 285             


Leu Pro Val Leu Ile Leu Ile Val Lys Lys Thr Cys Gly Asn Lys Ser 
    290                 295                 300                 


Ser Val Asn Ser Thr Val Leu Val Lys Asn Thr Lys Lys Thr Asn Pro 
305                 310                 315                 320 


Glu Ile Lys Glu Lys Pro Cys His Phe Glu Arg Cys Glu Gly Glu Lys 
                325                 330                 335     


His Ile Tyr Ser Pro Ile Ile Val Arg Glu Val Ile Glu Glu Glu Glu 
            340                 345                 350         


Pro Ser Glu Lys Ser Glu Ala Thr Tyr Met Thr Met His Pro Val Trp 
        355                 360                 365             


Pro Ser Leu Arg Ser Asp Arg Asn Asn Ser Leu Glu Lys Lys Ser Gly 
    370                 375                 380                 


Gly Gly Met Pro Lys Thr Gln Gln Ala Phe 
385                 390                 


<210>  1137
<211>  1342
<212>  PRT
<213>  Homo sapiens

<400>  1137

Met Glu Glu Glu Lys Asp Asp Ser Pro Gln Ala Asp Phe Cys Leu Gly 
1               5                   10                  15      


Thr Ala Leu His Ser Trp Gly Leu Trp Phe Thr Glu Glu Gly Ser Pro 
            20                  25                  30          


Ser Thr Met Leu Thr Gly Ile Ala Val Gly Ala Leu Leu Ala Leu Ala 
        35                  40                  45              


Leu Val Gly Val Leu Ile Leu Phe Met Phe Arg Arg Leu Arg Gln Phe 
    50                  55                  60                  


Arg Gln Ala Gln Pro Thr Pro Gln Tyr Arg Phe Arg Lys Arg Asp Lys 
65                  70                  75                  80  


Val Met Phe Tyr Gly Arg Lys Ile Met Arg Lys Val Thr Thr Leu Pro 
                85                  90                  95      


Asn Thr Leu Val Glu Asn Thr Ala Leu Pro Arg Gln Arg Ala Arg Lys 
            100                 105                 110         


Arg Thr Lys Val Leu Ser Leu Ala Lys Arg Ile Leu Arg Phe Lys Lys 
        115                 120                 125             


Glu Tyr Pro Ala Leu Gln Pro Lys Glu Pro Pro Pro Ser Leu Leu Glu 
    130                 135                 140                 


Ala Asp Leu Thr Glu Phe Asp Val Lys Asn Ser His Leu Pro Ser Glu 
145                 150                 155                 160 


Val Leu Tyr Met Leu Lys Asn Val Arg Val Leu Gly His Phe Glu Lys 
                165                 170                 175     


Pro Leu Phe Leu Glu Leu Cys Lys His Ile Val Phe Val Gln Leu Gln 
            180                 185                 190         


Glu Gly Glu His Val Phe Gln Pro Arg Glu Pro Asp Pro Ser Ile Cys 
        195                 200                 205             


Val Val Gln Asp Gly Arg Leu Glu Val Cys Ile Gln Asp Thr Asp Gly 
    210                 215                 220                 


Thr Glu Val Val Val Lys Glu Val Leu Ala Gly Asp Ser Val His Ser 
225                 230                 235                 240 


Leu Leu Ser Ile Leu Asp Ile Ile Thr Gly His Ala Ala Pro Tyr Lys 
                245                 250                 255     


Thr Val Ser Val Arg Ala Ala Ile Pro Ser Thr Ile Leu Arg Leu Pro 
            260                 265                 270         


Ala Ala Ala Phe His Gly Val Phe Glu Lys Tyr Pro Glu Thr Leu Val 
        275                 280                 285             


Arg Val Val Gln Ile Ile Met Val Arg Leu Gln Arg Val Thr Phe Leu 
    290                 295                 300                 


Ala Leu His Asn Tyr Leu Gly Leu Thr Thr Glu Leu Phe Asn Ala Glu 
305                 310                 315                 320 


Ser Gln Ala Ile Pro Leu Val Ser Val Ala Ser Val Ala Ala Gly Lys 
                325                 330                 335     


Ala Lys Lys Gln Val Phe Tyr Gly Glu Glu Glu Arg Leu Lys Lys Pro 
            340                 345                 350         


Pro Arg Leu Gln Glu Ser Cys Asp Ser Asp His Gly Gly Gly Arg Pro 
        355                 360                 365             


Ala Ala Ala Gly Pro Leu Leu Lys Arg Ser His Ser Val Pro Ala Pro 
    370                 375                 380                 


Ser Ile Arg Lys Gln Ile Leu Glu Glu Leu Glu Lys Pro Gly Ala Gly 
385                 390                 395                 400 


Asp Pro Asp Pro Ser Ala Pro Gln Gly Gly Pro Gly Ser Ala Thr Ser 
                405                 410                 415     


Asp Leu Gly Met Ala Cys Asp Arg Ala Arg Val Phe Leu His Ser Asp 
            420                 425                 430         


Glu His Pro Gly Ser Ser Val Ala Ser Lys Ser Arg Lys Ser Val Met 
        435                 440                 445             


Val Ala Glu Ile Pro Ser Thr Val Ser Gln His Ser Glu Ser His Thr 
    450                 455                 460                 


Asp Glu Thr Leu Ala Ser Arg Lys Ser Asp Ala Ile Phe Arg Ala Ala 
465                 470                 475                 480 


Lys Lys Asp Leu Leu Thr Leu Met Lys Leu Glu Asp Ser Ser Leu Leu 
                485                 490                 495     


Asp Gly Arg Val Ala Leu Leu His Val Pro Ala Gly Thr Val Val Ser 
            500                 505                 510         


Arg Gln Gly Asp Gln Asp Ala Ser Ile Leu Phe Val Val Ser Gly Leu 
        515                 520                 525             


Leu His Val Tyr Gln Arg Lys Ile Gly Ser Gln Glu Asp Thr Cys Leu 
    530                 535                 540                 


Phe Leu Thr Arg Pro Gly Glu Met Val Gly Gln Leu Ala Val Leu Thr 
545                 550                 555                 560 


Gly Glu Pro Leu Ile Phe Thr Val Lys Ala Asn Arg Asp Cys Ser Phe 
                565                 570                 575     


Leu Ser Ile Ser Lys Ala His Phe Tyr Glu Ile Met Arg Lys Gln Pro 
            580                 585                 590         


Thr Val Val Leu Gly Val Ala His Thr Val Val Lys Arg Met Ser Ser 
        595                 600                 605             


Phe Val Arg Gln Ile Asp Phe Ala Leu Asp Trp Val Glu Val Glu Ala 
    610                 615                 620                 


Gly Arg Ala Ile Tyr Arg Gln Gly Asp Lys Ser Asp Cys Thr Tyr Ile 
625                 630                 635                 640 


Met Leu Ser Gly Arg Leu Arg Ser Val Ile Arg Lys Asp Asp Gly Lys 
                645                 650                 655     


Lys Arg Leu Ala Gly Glu Tyr Gly Arg Gly Asp Leu Val Gly Val Val 
            660                 665                 670         


Glu Thr Leu Thr His Gln Ala Arg Ala Thr Thr Val His Ala Val Arg 
        675                 680                 685             


Asp Ser Glu Leu Ala Lys Leu Pro Ala Gly Ala Leu Thr Ser Ile Lys 
    690                 695                 700                 


Arg Arg Tyr Pro Gln Val Val Thr Arg Leu Ile His Leu Leu Gly Glu 
705                 710                 715                 720 


Lys Ile Leu Gly Ser Leu Gln Gln Gly Pro Val Thr Gly His Gln Leu 
                725                 730                 735     


Gly Leu Pro Thr Glu Gly Ser Lys Trp Asp Leu Gly Asn Pro Ala Val 
            740                 745                 750         


Asn Leu Ser Thr Val Ala Val Met Pro Val Ser Glu Glu Val Pro Leu 
        755                 760                 765             


Thr Ala Phe Ala Leu Glu Leu Glu His Ala Leu Ser Ala Ile Gly Pro 
    770                 775                 780                 


Thr Leu Leu Leu Thr Ser Asp Asn Ile Lys Arg Arg Leu Gly Ser Ala 
785                 790                 795                 800 


Ala Leu Asp Ser Val His Glu Tyr Arg Leu Ser Ser Trp Leu Gly Gln 
                805                 810                 815     


Gln Glu Asp Thr His Arg Ile Val Leu Tyr Gln Ala Asp Gly Thr Leu 
            820                 825                 830         


Thr Pro Trp Thr Gln Arg Cys Val Arg Gln Ala Asp Cys Ile Leu Ile 
        835                 840                 845             


Val Gly Leu Gly Asp Gln Glu Pro Thr Val Gly Glu Leu Glu Arg Met 
    850                 855                 860                 


Leu Glu Ser Thr Ala Val Arg Ala Gln Lys Gln Leu Ile Leu Leu His 
865                 870                 875                 880 


Arg Glu Glu Gly Pro Ala Pro Ala Arg Thr Val Glu Trp Leu Asn Met 
                885                 890                 895     


Arg Ser Trp Cys Ser Gly His Leu His Leu Cys Cys Pro Arg Arg Val 
            900                 905                 910         


Phe Ser Arg Arg Ser Leu Pro Lys Leu Val Glu Met Tyr Lys His Val 
        915                 920                 925             


Phe Gln Arg Pro Pro Asp Arg His Ser Asp Phe Ser Arg Leu Ala Arg 
    930                 935                 940                 


Val Leu Thr Gly Asn Ala Ile Ala Leu Val Leu Gly Gly Gly Gly Ala 
945                 950                 955                 960 


Arg Gly Cys Ala Gln Val Gly Val Leu Lys Ala Leu Ala Glu Cys Gly 
                965                 970                 975     


Ile Pro Val Asp Met Val Gly Gly Thr Ser Ile Gly Ala Phe Val Gly 
            980                 985                 990         


Ala Leu Tyr Ser Glu Glu Arg Asn  Tyr Ser Gln Met Arg  Ile Arg Ala 
        995                 1000                 1005             


Lys Gln  Trp Ala Glu Gly Met  Thr Ser Leu Met Lys  Ala Ala Leu 
    1010                 1015                 1020             


Asp Leu  Thr Tyr Pro Ile Thr  Ser Met Phe Ser Gly  Ala Gly Phe 
    1025                 1030                 1035             


Asn Ser  Ser Ile Phe Ser Val  Phe Lys Asp Gln Gln  Ile Glu Asp 
    1040                 1045                 1050             


Leu Trp  Ile Pro Tyr Phe Ala  Ile Thr Thr Asp Ile  Thr Ala Ser 
    1055                 1060                 1065             


Ala Met  Arg Val His Thr Asp  Gly Ser Leu Trp Trp  Tyr Val Arg 
    1070                 1075                 1080             


Ala Ser  Met Ser Leu Ser Gly  Tyr Met Pro Pro Leu  Cys Asp Pro 
    1085                 1090                 1095             


Lys Asp  Gly His Leu Leu Met  Asp Gly Gly Tyr Ile  Asn Asn Leu 
    1100                 1105                 1110             


Pro Ala  Asp Val Ala Arg Ser  Met Gly Ala Lys Val  Val Ile Ala 
    1115                 1120                 1125             


Ile Asp  Val Gly Ser Arg Asp  Glu Thr Asp Leu Thr  Asn Tyr Gly 
    1130                 1135                 1140             


Asp Ala  Leu Ser Gly Trp Trp  Leu Leu Trp Lys Arg  Trp Asn Pro 
    1145                 1150                 1155             


Leu Ala  Thr Lys Val Lys Val  Leu Asn Met Ala Glu  Ile Gln Thr 
    1160                 1165                 1170             


Arg Leu  Ala Tyr Val Cys Cys  Val Arg Gln Leu Glu  Val Val Lys 
    1175                 1180                 1185             


Ser Ser  Asp Tyr Cys Glu Tyr  Leu Arg Pro Pro Ile  Asp Ser Tyr 
    1190                 1195                 1200             


Ser Thr  Leu Asp Phe Gly Lys  Phe Asn Glu Ile Cys  Glu Val Gly 
    1205                 1210                 1215             


Tyr Gln  His Gly Arg Thr Val  Phe Asp Ile Trp Gly  Arg Ser Gly 
    1220                 1225                 1230             


Val Leu  Glu Lys Met Leu Arg  Asp Gln Gln Gly Pro  Ser Lys Lys 
    1235                 1240                 1245             


Pro Ala  Ser Ala Val Leu Thr  Cys Pro Asn Ala Ser  Phe Thr Asp 
    1250                 1255                 1260             


Leu Ala  Glu Ile Val Ser Arg  Ile Glu Pro Ala Lys  Pro Ala Met 
    1265                 1270                 1275             


Val Asp  Asp Glu Ser Asp Tyr  Gln Thr Glu Tyr Glu  Glu Glu Leu 
    1280                 1285                 1290             


Leu Asp  Val Pro Arg Asp Ala  Tyr Ala Asp Phe Gln  Ser Thr Ser 
    1295                 1300                 1305             


Ala Gln  Gln Gly Ser Asp Leu  Glu Asp Glu Ser Ser  Leu Arg His 
    1310                 1315                 1320             


Arg His  Pro Ser Leu Ala Phe  Pro Lys Leu Ser Glu  Gly Ser Ser 
    1325                 1330                 1335             


Asp Gln  Asp Gly 
    1340         


<210>  1138
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  1138

Met Ser His Ser Ser Val Thr Arg Glu Ala Pro Gln Leu Leu Ser Gln 
1               5                   10                  15      


Arg Gln Arg Arg Glu Val Arg Gly Val Trp Gly Trp Gly Cys Leu Pro 
            20                  25                  30          


Gly Pro Arg Gly Gly Pro Ala Leu Phe Gly Leu Val Thr Phe Gly Gln 
        35                  40                  45              


Ser Gly Asp Cys Cys Thr Asp Ser Gly Thr Met Asn Ile Phe Asp Arg 
    50                  55                  60                  


Lys Ile Asn Phe Asp Ala Leu Leu Lys Phe Ser His Ile Thr Pro Ser 
65                  70                  75                  80  


Thr Gln Gln His Leu Lys Lys Val Tyr Ala Ser Phe Ala Leu Cys Met 
                85                  90                  95      


Phe Val Ala Ala Ala Gly Ala Tyr Val His Met Val Thr His Phe Ile 
            100                 105                 110         


Gln Ala Gly Leu Leu Ser Ala Leu Gly Ser Leu Ile Leu Met Ile Trp 
        115                 120                 125             


Leu Met Ala Thr Pro His Ser His Glu Thr Glu Gln Lys Arg Leu Gly 
    130                 135                 140                 


Leu Leu Ala Gly Phe Ala Phe Leu Thr Gly Val Gly Leu Gly Pro Ala 
145                 150                 155                 160 


Leu Glu Phe Cys Ile Ala Val Asn Pro Ser Ile Leu Pro Thr Ala Phe 
                165                 170                 175     


Met Gly Thr Ala Met Ile Phe Thr Cys Phe Thr Leu Ser Ala Leu Tyr 
            180                 185                 190         


Ala Arg Arg Arg Ser Tyr Leu Phe Leu Gly Gly Ile Leu Met Ser Ala 
        195                 200                 205             


Leu Ser Leu Leu Leu Leu Ser Ser Leu Gly Asn Val Phe Phe Gly Ser 
    210                 215                 220                 


Ile Trp Leu Phe Gln Ala Asn Leu Tyr Val Gly Leu Val Val Met Cys 
225                 230                 235                 240 


Gly Phe Val Leu Phe Asp Thr Gln Leu Ile Ile Glu Lys Ala Glu His 
                245                 250                 255     


Gly Asp Gln Asp Tyr Ile Trp His Cys Ile Asp Leu Phe Leu Asp Phe 
            260                 265                 270         


Ile Thr Val Phe Arg Lys Leu Met Met Ile Leu Ala Met Asn Glu Lys 
        275                 280                 285             


Asp Lys Lys Lys Glu Lys Lys 
    290                 295 


<210>  1139
<211>  904
<212>  PRT
<213>  Homo sapiens

<400>  1139

Met Gly Met Asp Leu Thr Cys Pro Phe Gly Ile Ser Pro Ala Cys Gly 
1               5                   10                  15      


Ala Gln Ala Ser Trp Ser Ile Phe Gly Ala Asp Ala Ala Glu Val Pro 
            20                  25                  30          


Gly Thr Arg Gly His Ser Gln Gln Glu Ala Ala Met Pro His Ile Pro 
        35                  40                  45              


Glu Asp Glu Glu Pro Pro Gly Glu Pro Gln Ala Ala Gln Ser Pro Ala 
    50                  55                  60                  


Gly Gln Gly Pro Pro Ala Ala Gly Val Ser Cys Ser Pro Thr Pro Thr 
65                  70                  75                  80  


Ile Val Leu Thr Gly Asp Ala Thr Ser Pro Glu Gly Glu Thr Asp Lys 
                85                  90                  95      


Asn Leu Ala Asn Arg Val His Ser Pro His Lys Arg Leu Ser His Arg 
            100                 105                 110         


His Leu Lys Val Ser Thr Ala Ser Leu Thr Ser Val Asp Pro Ala Gly 
        115                 120                 125             


His Ile Ile Asp Leu Val Asn Asp Gln Leu Pro Asp Ile Ser Ile Ser 
    130                 135                 140                 


Glu Glu Asp Lys Lys Lys Asn Leu Ala Leu Leu Glu Glu Ala Lys Leu 
145                 150                 155                 160 


Val Ser Glu Arg Phe Leu Thr Arg Arg Gly Arg Lys Ser Arg Ser Ser 
                165                 170                 175     


Pro Gly Asp Ser Pro Ser Ala Val Ser Pro Asn Leu Ser Pro Ser Ala 
            180                 185                 190         


Ser Pro Thr Ser Ser Arg Ser Asn Ser Leu Thr Val Pro Thr Pro Pro 
        195                 200                 205             


Gly Leu Asp Val Cys Ser Gly Pro Pro Ser Pro Leu Pro Gly Ala Pro 
    210                 215                 220                 


Pro Gln Gln Lys Gly Asp Glu Ala Asp Val Ser Ser Pro His Pro Gly 
225                 230                 235                 240 


Glu Pro Asn Val Pro Lys Gly Leu Ala Asp Arg Lys Gln Asn Asp Gln 
                245                 250                 255     


Arg Lys Val Ser Gln Gly Arg Leu Ala Pro Arg Pro Pro Pro Val Glu 
            260                 265                 270         


Lys Ser Lys Glu Ile Ala Ile Glu Gln Lys Glu Asn Phe Asp Pro Leu 
        275                 280                 285             


Gln Tyr Pro Glu Thr Thr Pro Lys Gly Leu Ala Pro Val Thr Asn Ser 
    290                 295                 300                 


Ser Gly Lys Met Ala Leu Asn Ser Pro Gln Pro Gly Pro Val Glu Ser 
305                 310                 315                 320 


Glu Leu Gly Lys Gln Leu Leu Lys Thr Gly Trp Glu Gly Ser Pro Leu 
                325                 330                 335     


Pro Arg Ser Pro Thr Gln Asp Ala Ala Gly Val Gly Pro Pro Ala Ser 
            340                 345                 350         


Gln Gly Arg Gly Pro Ala Gly Glu Pro Met Gly Pro Glu Ala Gly Ser 
        355                 360                 365             


Lys Ala Glu Leu Pro Pro Thr Val Ser Arg Pro Pro Leu Leu Arg Gly 
    370                 375                 380                 


Leu Ser Trp Asp Ser Gly Pro Glu Glu Pro Gly Pro Arg Leu Gln Lys 
385                 390                 395                 400 


Val Leu Ala Lys Leu Pro Leu Ala Glu Glu Glu Lys Arg Phe Ala Gly 
                405                 410                 415     


Lys Ala Gly Gly Lys Leu Ala Lys Ala Pro Gly Leu Lys Asp Phe Gln 
            420                 425                 430         


Ile Gln Val Gln Pro Val Arg Met Gln Lys Leu Thr Lys Leu Arg Glu 
        435                 440                 445             


Glu His Ile Leu Met Arg Asn Gln Asn Leu Val Gly Leu Lys Leu Pro 
    450                 455                 460                 


Asp Leu Ser Glu Ala Ala Glu Gln Glu Lys Gly Leu Pro Ser Glu Leu 
465                 470                 475                 480 


Ser Pro Ala Ile Glu Glu Glu Glu Ser Lys Ser Gly Leu Asp Val Met 
                485                 490                 495     


Pro Asn Ile Ser Asp Val Leu Leu Arg Lys Leu Arg Val His Arg Ser 
            500                 505                 510         


Leu Pro Gly Ser Ala Pro Pro Leu Thr Glu Lys Glu Val Glu Asn Val 
        515                 520                 525             


Phe Val Gln Leu Ser Leu Ala Phe Arg Asn Asp Ser Tyr Thr Leu Glu 
    530                 535                 540                 


Ser Arg Ile Asn Gln Ala Glu Arg Glu Arg Asn Leu Thr Glu Glu Asn 
545                 550                 555                 560 


Thr Glu Lys Glu Leu Glu Asn Phe Lys Ala Ser Ile Thr Ser Ser Ala 
                565                 570                 575     


Ser Leu Trp His His Cys Glu His Arg Glu Thr Tyr Gln Lys Leu Leu 
            580                 585                 590         


Glu Asp Ile Ala Val Leu His Arg Leu Ala Ala Arg Leu Ser Ser Arg 
        595                 600                 605             


Ala Glu Val Val Gly Ala Val Arg Gln Glu Lys Arg Met Ser Lys Ala 
    610                 615                 620                 


Thr Glu Val Met Met Gln Tyr Val Glu Asn Leu Lys Arg Thr Tyr Glu 
625                 630                 635                 640 


Lys Asp His Ala Glu Leu Met Glu Phe Lys Lys Leu Ala Asn Gln Asn 
                645                 650                 655     


Ser Ser Arg Ser Cys Gly Pro Ser Glu Asp Gly Val Pro Arg Thr Ala 
            660                 665                 670         


Arg Ser Met Ser Leu Thr Leu Gly Lys Asn Met Pro Arg Arg Arg Val 
        675                 680                 685             


Ser Val Ala Val Val Pro Lys Phe Asn Ala Leu Asn Leu Pro Gly Gln 
    690                 695                 700                 


Thr Pro Ser Ser Ser Ser Ile Pro Ser Leu Pro Ala Leu Ser Glu Ser 
705                 710                 715                 720 


Pro Asn Gly Lys Gly Ser Leu Pro Val Thr Ser Ala Leu Pro Ala Leu 
                725                 730                 735     


Leu Glu Asn Gly Lys Thr Asn Gly Asp Pro Asp Cys Glu Ala Ser Ala 
            740                 745                 750         


Pro Ala Leu Thr Leu Ser Cys Leu Glu Glu Leu Ser Gln Glu Thr Lys 
        755                 760                 765             


Ala Arg Met Glu Glu Glu Ala Tyr Ser Lys Gly Phe Gln Glu Gly Leu 
    770                 775                 780                 


Lys Lys Thr Lys Glu Leu Gln Asp Leu Lys Glu Glu Glu Glu Glu Gln 
785                 790                 795                 800 


Lys Ser Glu Ser Pro Glu Glu Pro Glu Glu Val Glu Glu Thr Glu Glu 
                805                 810                 815     


Glu Glu Lys Gly Pro Arg Ser Ser Lys Leu Glu Glu Leu Val His Phe 
            820                 825                 830         


Leu Gln Val Met Tyr Pro Lys Leu Cys Gln His Trp Gln Val Ile Trp 
        835                 840                 845             


Met Met Ala Ala Val Met Leu Val Leu Thr Val Val Leu Gly Leu Tyr 
    850                 855                 860                 


Asn Ser Tyr Asn Ser Cys Ala Glu Gln Ala Asp Gly Pro Leu Gly Arg 
865                 870                 875                 880 


Ser Thr Cys Ser Ala Ala Gln Arg Asp Ser Trp Trp Ser Ser Gly Leu 
                885                 890                 895     


Gln His Glu Gln Pro Thr Glu Gln 
            900                 


<210>  1140
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  1140

Met Ala Ser Gly Ser Asn Trp Leu Ser Gly Val Asn Val Val Leu Val 
1               5                   10                  15      


Met Ala Tyr Gly Ser Leu Val Phe Val Leu Leu Phe Ile Phe Val Lys 
            20                  25                  30          


Arg Gln Ile Met Arg Phe Ala Met Lys Ser Arg Arg Gly Pro His Val 
        35                  40                  45              


Pro Val Gly His Asn Ala Pro Lys Asp Leu Lys Glu Glu Ile Asp Ile 
    50                  55                  60                  


Arg Leu Ser Arg Val Gln Asp Ile Lys Tyr Glu Pro Gln Leu Leu Ala 
65                  70                  75                  80  


Asp Asp Asp Ala Arg Leu Leu Gln Leu Glu Thr Gln Gly Asn Gln Ser 
                85                  90                  95      


Cys Tyr Asn Tyr Leu Tyr Arg Met Lys Ala Leu Asp Ala Ile Arg Thr 
            100                 105                 110         


Ser Glu Ile Pro Phe His Ser Glu Gly Arg His Pro Arg Ser Leu Met 
        115                 120                 125             


Gly Lys Asn Phe Arg Ser Tyr Leu Leu Asp Leu Arg Asn Thr Ser Thr 
    130                 135                 140                 


Pro Phe Lys Gly Val Arg Lys Ala Leu Ile Asp Thr Leu Leu Asp Gly 
145                 150                 155                 160 


Tyr Glu Thr Ala Arg Tyr Gly Thr Gly Val Phe Gly Gln Asn Glu Tyr 
                165                 170                 175     


Leu Arg Tyr Gln Glu Ala Leu Ser Glu Leu Ala Thr Ala Val Lys Ala 
            180                 185                 190         


Arg Ile Gly Ser Ser Gln Arg His His Gln Ser Ala Ala Lys Asp Leu 
        195                 200                 205             


Thr Gln Ser Pro Glu Val Ser Pro Thr Thr Ile Gln Val Thr Tyr Leu 
    210                 215                 220                 


Pro Ser Ser Gln Lys Ser Lys Arg Ala Lys His Phe Leu Glu Leu Lys 
225                 230                 235                 240 


Ser Phe Lys Asp Asn Tyr Asn Thr Leu Glu Ser Thr Leu 
                245                 250             


<210>  1141
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  1141

Met Leu Ala Phe Ser Glu Met Pro Lys Pro Pro Asp Tyr Ser Glu Leu 
1               5                   10                  15      


Ser Asp Ser Leu Thr Leu Ala Val Gly Thr Gly Arg Phe Ser Gly Pro 
            20                  25                  30          


Leu His Arg Ala Trp Arg Met Met Asn Phe Arg Gln Arg Met Gly Trp 
        35                  40                  45              


Ile Gly Val Gly Leu Tyr Leu Leu Ala Ser Ala Ala Ala Phe Tyr Tyr 
    50                  55                  60                  


Val Phe Glu Ile Ser Glu Thr Tyr Asn Arg Leu Ala Leu Glu His Ile 
65                  70                  75                  80  


Gln Gln His Pro Glu Glu Pro Leu Glu Gly Thr Thr Trp Thr His Ser 
                85                  90                  95      


Leu Lys Ala Gln Leu Leu Ser Leu Pro Phe Trp Val Trp Thr Val Ile 
            100                 105                 110         


Phe Leu Val Pro Tyr Leu Gln Met Phe Leu Phe Leu Tyr Ser Cys Thr 
        115                 120                 125             


Arg Ala Asp Pro Lys Thr Val Gly Tyr Cys Ile Ile Pro Ile Cys Leu 
    130                 135                 140                 


Ala Val Ile Cys Asn Arg His Gln Ala Phe Val Lys Ala Ser Asn Gln 
145                 150                 155                 160 


Ile Ser Arg Leu Gln Leu Ile Asp Thr 
                165                 


<210>  1142
<211>  667
<212>  PRT
<213>  Homo sapiens

<400>  1142

Met Glu Thr Leu Glu Ser Glu Leu Thr Cys Pro Ile Cys Leu Glu Leu 
1               5                   10                  15      


Phe Glu Asp Pro Leu Leu Leu Pro Cys Ala His Ser Leu Cys Phe Asn 
            20                  25                  30          


Cys Ala His Arg Ile Leu Val Ser His Cys Ala Thr Asn Glu Ser Val 
        35                  40                  45              


Glu Ser Ile Thr Ala Phe Gln Cys Pro Thr Cys Arg His Val Ile Thr 
    50                  55                  60                  


Leu Ser Gln Arg Gly Leu Asp Gly Leu Lys Arg Asn Val Thr Leu Gln 
65                  70                  75                  80  


Asn Ile Ile Asp Arg Phe Gln Lys Ala Ser Val Ser Gly Pro Asn Ser 
                85                  90                  95      


Pro Ser Glu Thr Arg Arg Glu Arg Ala Phe Asp Ala Asn Thr Met Thr 
            100                 105                 110         


Ser Ala Glu Lys Val Leu Cys Gln Phe Cys Asp Gln Asp Pro Ala Gln 
        115                 120                 125             


Asp Ala Val Lys Thr Cys Val Thr Cys Glu Val Ser Tyr Cys Asp Glu 
    130                 135                 140                 


Cys Leu Lys Ala Thr His Pro Asn Lys Lys Pro Phe Thr Gly His Arg 
145                 150                 155                 160 


Leu Ile Glu Pro Ile Pro Asp Ser His Ile Arg Gly Leu Met Cys Leu 
                165                 170                 175     


Glu His Glu Asp Glu Lys Val Asn Met Tyr Cys Val Thr Asp Asp Gln 
            180                 185                 190         


Leu Ile Cys Ala Leu Cys Lys Leu Val Gly Arg His Arg Asp His Gln 
        195                 200                 205             


Val Ala Ala Leu Ser Glu Arg Tyr Asp Lys Leu Lys Gln Asn Leu Glu 
    210                 215                 220                 


Ser Asn Leu Thr Asn Leu Ile Lys Arg Asn Thr Glu Leu Glu Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Leu Ile Gln Thr Cys Gln His Val Glu Val Asn Ala Ser 
                245                 250                 255     


Arg Gln Glu Ala Lys Leu Thr Glu Glu Cys Asp Leu Leu Ile Glu Ile 
            260                 265                 270         


Ile Gln Gln Arg Arg Gln Ile Ile Gly Thr Lys Ile Lys Glu Gly Lys 
        275                 280                 285             


Val Met Arg Leu Arg Lys Leu Ala Gln Gln Ile Ala Asn Cys Lys Gln 
    290                 295                 300                 


Cys Ile Glu Arg Ser Ala Ser Leu Ile Ser Gln Ala Glu His Ser Leu 
305                 310                 315                 320 


Lys Glu Asn Asp His Ala Arg Phe Leu Gln Thr Ala Lys Asn Ile Thr 
                325                 330                 335     


Glu Arg Val Ser Met Ala Thr Ala Ser Ser Gln Val Leu Ile Pro Glu 
            340                 345                 350         


Ile Asn Leu Asn Asp Thr Phe Asp Thr Phe Ala Leu Asp Phe Ser Arg 
        355                 360                 365             


Glu Lys Lys Leu Leu Glu Cys Leu Asp Tyr Leu Thr Ala Pro Asn Pro 
    370                 375                 380                 


Pro Thr Ile Arg Glu Glu Leu Cys Thr Ala Ser Tyr Asp Thr Ile Thr 
385                 390                 395                 400 


Val His Trp Thr Ser Asp Asp Glu Phe Ser Val Val Ser Tyr Glu Leu 
                405                 410                 415     


Gln Tyr Thr Ile Phe Thr Gly Gln Ala Asn Val Val Ser Leu Cys Asn 
            420                 425                 430         


Ser Ala Asp Ser Trp Met Ile Val Pro Asn Ile Lys Gln Asn His Tyr 
        435                 440                 445             


Thr Val His Gly Leu Gln Ser Gly Thr Lys Tyr Ile Phe Met Val Lys 
    450                 455                 460                 


Ala Ile Asn Gln Ala Gly Ser Arg Ser Ser Glu Pro Gly Lys Leu Lys 
465                 470                 475                 480 


Thr Asn Ser Gln Pro Phe Lys Leu Asp Pro Lys Ser Ala His Arg Lys 
                485                 490                 495     


Leu Lys Val Ser His Asp Asn Leu Thr Val Glu Arg Asp Glu Ser Ser 
            500                 505                 510         


Ser Lys Lys Ser His Thr Pro Glu Arg Phe Thr Ser Gln Gly Ser Tyr 
        515                 520                 525             


Gly Val Ala Gly Asn Val Phe Ile Asp Ser Gly Arg His Tyr Trp Glu 
    530                 535                 540                 


Val Val Ile Ser Gly Ser Thr Trp Tyr Ala Ile Gly Leu Ala Tyr Lys 
545                 550                 555                 560 


Ser Ala Pro Lys His Glu Trp Ile Gly Lys Asn Ser Ala Ser Trp Ala 
                565                 570                 575     


Leu Cys Arg Cys Asn Asn Asn Trp Val Val Arg His Asn Ser Lys Glu 
            580                 585                 590         


Ile Pro Ile Glu Pro Ala Pro His Leu Arg Arg Val Gly Ile Leu Leu 
        595                 600                 605             


Asp Tyr Asp Asn Gly Ser Ile Ala Phe Tyr Asp Ala Leu Asn Ser Ile 
    610                 615                 620                 


His Leu Tyr Thr Phe Asp Val Ala Phe Ala Gln Pro Val Cys Pro Thr 
625                 630                 635                 640 


Phe Thr Val Trp Asn Lys Cys Leu Thr Ile Ile Thr Gly Leu Pro Ile 
                645                 650                 655     


Pro Asp His Leu Asp Cys Thr Glu Gln Leu Pro 
            660                 665         


<210>  1143
<211>  993
<212>  PRT
<213>  Homo sapiens

<400>  1143

Met Arg Pro Val Ala Leu Leu Leu Leu Pro Ser Leu Leu Ala Leu Leu 
1               5                   10                  15      


Ala His Gly Leu Ser Leu Glu Ala Pro Thr Val Gly Lys Gly Gln Ala 
            20                  25                  30          


Pro Gly Ile Glu Glu Thr Asp Gly Glu Leu Thr Ala Ala Pro Thr Pro 
        35                  40                  45              


Glu Gln Pro Glu Arg Gly Val His Phe Val Thr Thr Ala Pro Thr Leu 
    50                  55                  60                  


Lys Leu Leu Asn His His Pro Leu Leu Glu Glu Phe Leu Gln Glu Gly 
65                  70                  75                  80  


Leu Glu Lys Gly Asp Glu Glu Leu Arg Pro Ala Leu Pro Phe Gln Pro 
                85                  90                  95      


Asp Pro Pro Ala Pro Phe Thr Pro Ser Pro Leu Pro Arg Leu Ala Asn 
            100                 105                 110         


Gln Asp Ser Arg Pro Val Phe Thr Ser Pro Thr Pro Ala Met Ala Ala 
        115                 120                 125             


Val Pro Thr Gln Pro Gln Ser Lys Glu Gly Pro Trp Ser Pro Glu Ser 
    130                 135                 140                 


Glu Ser Pro Met Leu Arg Ile Thr Ala Pro Leu Pro Pro Gly Pro Ser 
145                 150                 155                 160 


Met Ala Val Pro Thr Leu Gly Pro Gly Glu Ile Ala Ser Thr Thr Pro 
                165                 170                 175     


Pro Ser Arg Ala Trp Thr Pro Thr Gln Glu Gly Pro Gly Asp Met Gly 
            180                 185                 190         


Arg Pro Trp Val Ala Glu Val Val Ser Gln Gly Ala Gly Ile Gly Ile 
        195                 200                 205             


Gln Gly Thr Ile Thr Ser Ser Thr Ala Ser Gly Asp Asp Glu Glu Thr 
    210                 215                 220                 


Thr Thr Thr Thr Thr Ile Ile Thr Thr Thr Ile Thr Thr Val Gln Thr 
225                 230                 235                 240 


Pro Gly Pro Cys Ser Trp Asn Phe Ser Gly Pro Glu Gly Ser Leu Asp 
                245                 250                 255     


Ser Pro Thr Asp Leu Ser Ser Pro Thr Asp Val Gly Leu Asp Cys Phe 
            260                 265                 270         


Phe Tyr Ile Ser Val Tyr Pro Gly Tyr Gly Val Glu Ile Lys Val Gln 
        275                 280                 285             


Asn Ile Ser Leu Arg Glu Gly Glu Thr Val Thr Val Glu Gly Leu Gly 
    290                 295                 300                 


Gly Pro Asp Pro Leu Pro Leu Ala Asn Gln Ser Phe Leu Leu Arg Gly 
305                 310                 315                 320 


Gln Val Ile Arg Ser Pro Thr His Gln Ala Ala Leu Arg Phe Gln Ser 
                325                 330                 335     


Leu Pro Pro Pro Ala Gly Pro Gly Thr Phe His Phe His Tyr Gln Ala 
            340                 345                 350         


Tyr Leu Leu Ser Cys His Phe Pro Arg Arg Pro Ala Tyr Gly Asp Val 
        355                 360                 365             


Thr Val Thr Ser Leu His Pro Gly Gly Ser Ala Arg Phe His Cys Ala 
    370                 375                 380                 


Thr Gly Tyr Gln Leu Lys Gly Ala Arg His Leu Thr Cys Leu Asn Ala 
385                 390                 395                 400 


Thr Gln Pro Phe Trp Asp Ser Lys Glu Pro Val Cys Ile Ala Ala Cys 
                405                 410                 415     


Gly Gly Val Ile Arg Asn Ala Thr Thr Gly Arg Ile Val Ser Pro Gly 
            420                 425                 430         


Phe Pro Gly Asn Tyr Ser Asn Asn Leu Thr Cys His Trp Leu Leu Glu 
        435                 440                 445             


Ala Pro Glu Gly Gln Arg Leu His Leu His Phe Glu Lys Val Ser Leu 
    450                 455                 460                 


Ala Glu Asp Asp Asp Arg Leu Ile Ile Arg Asn Gly Asp Asn Val Glu 
465                 470                 475                 480 


Ala Pro Pro Val Tyr Asp Ser Tyr Glu Val Glu Tyr Leu Pro Ile Glu 
                485                 490                 495     


Gly Leu Leu Ser Ser Gly Lys His Phe Phe Val Glu Leu Ser Thr Asp 
            500                 505                 510         


Ser Ser Gly Ala Ala Ala Gly Met Ala Leu Arg Tyr Glu Ala Phe Gln 
        515                 520                 525             


Gln Gly His Cys Tyr Glu Pro Phe Val Lys Tyr Gly Asn Phe Ser Ser 
    530                 535                 540                 


Ser Thr Pro Thr Tyr Pro Val Gly Thr Thr Val Glu Phe Ser Cys Asp 
545                 550                 555                 560 


Pro Gly Tyr Thr Leu Glu Gln Gly Ser Ile Ile Ile Glu Cys Val Asp 
                565                 570                 575     


Pro His Asp Pro Gln Trp Asn Glu Thr Glu Pro Ala Cys Arg Ala Val 
            580                 585                 590         


Cys Ser Gly Glu Ile Thr Asp Ser Ala Gly Val Val Leu Ser Pro Asn 
        595                 600                 605             


Trp Pro Glu Pro Tyr Gly Arg Gly Gln Asp Cys Ile Trp Gly Val His 
    610                 615                 620                 


Val Glu Glu Asp Lys Arg Ile Met Leu Asp Ile Arg Val Leu Arg Ile 
625                 630                 635                 640 


Gly Pro Gly Asp Val Leu Thr Phe Tyr Asp Gly Asp Asp Leu Thr Ala 
                645                 650                 655     


Arg Val Leu Gly Gln Tyr Ser Gly Pro Arg Ser His Phe Lys Leu Phe 
            660                 665                 670         


Thr Ser Met Ala Asp Val Thr Ile Gln Phe Gln Ser Asp Pro Gly Thr 
        675                 680                 685             


Ser Val Leu Gly Tyr Gln Gln Gly Phe Val Ile His Phe Phe Glu Val 
    690                 695                 700                 


Pro Arg Asn Asp Thr Cys Pro Glu Leu Pro Glu Ile Pro Asn Gly Trp 
705                 710                 715                 720 


Lys Ser Pro Ser Gln Pro Glu Leu Val His Gly Thr Val Val Thr Tyr 
                725                 730                 735     


Gln Cys Tyr Pro Gly Tyr Gln Val Val Gly Ser Ser Val Leu Met Cys 
            740                 745                 750         


Gln Trp Asp Leu Thr Trp Ser Glu Asp Leu Pro Ser Cys Gln Arg Val 
        755                 760                 765             


Thr Ser Cys His Asp Pro Gly Asp Val Glu His Ser Arg Arg Leu Ile 
    770                 775                 780                 


Ser Ser Pro Lys Phe Pro Val Gly Ala Thr Val Gln Tyr Ile Cys Asp 
785                 790                 795                 800 


Gln Gly Phe Val Leu Met Gly Ser Ser Ile Leu Thr Cys His Asp Arg 
                805                 810                 815     


Gln Ala Gly Ser Pro Lys Trp Ser Asp Arg Ala Pro Lys Cys Leu Leu 
            820                 825                 830         


Glu Gln Leu Lys Pro Cys His Gly Leu Ser Ala Pro Glu Asn Gly Ala 
        835                 840                 845             


Arg Ser Pro Glu Lys Gln Leu His Pro Ala Gly Ala Thr Ile His Phe 
    850                 855                 860                 


Ser Cys Ala Pro Gly Tyr Val Leu Lys Gly Gln Ala Ser Ile Lys Cys 
865                 870                 875                 880 


Val Pro Gly His Pro Ser His Trp Ser Asp Pro Pro Pro Ile Cys Arg 
                885                 890                 895     


Ala Ala Ser Leu Asp Gly Phe Tyr Asn Ser Arg Ser Leu Asp Val Ala 
            900                 905                 910         


Lys Ala Pro Ala Ala Ser Ser Thr Leu Asp Ala Ala His Ile Ala Ala 
        915                 920                 925             


Ala Ile Phe Leu Pro Leu Val Ala Met Val Leu Leu Val Gly Gly Val 
    930                 935                 940                 


Tyr Phe Tyr Phe Ser Arg Leu Gln Gly Lys Ser Ser Leu Gln Leu Pro 
945                 950                 955                 960 


Arg Pro Arg Pro Arg Pro Tyr Asn Arg Ile Thr Ile Glu Ser Ala Phe 
                965                 970                 975     


Asp Asn Pro Thr Tyr Glu Thr Gly Glu Thr Arg Glu Tyr Glu Val Ser 
            980                 985                 990         


Ile 
    


<210>  1144
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  1144

Met Lys His Val Leu Asn Leu Tyr Leu Leu Gly Val Val Leu Thr Leu 
1               5                   10                  15      


Leu Ser Ile Phe Val Arg Val Met Glu Ser Leu Glu Gly Leu Leu Glu 
            20                  25                  30          


Ser Pro Ser Pro Gly Thr Ser Trp Thr Thr Arg Ser Gln Leu Ala Asn 
        35                  40                  45              


Thr Glu Pro Thr Lys Gly Leu Pro Asp His Pro Ser Arg Ser Met 
    50                  55                  60              


<210>  1145
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  1145

Met Ala Asp Trp Ala Arg Ala Gln Ser Pro Gly Ala Val Glu Glu Ile 
1               5                   10                  15      


Leu Asp Arg Glu Asn Lys Arg Met Ala Asp Ser Leu Ala Ser Lys Val 
            20                  25                  30          


Thr Arg Leu Lys Ser Leu Ala Leu Asp Ile Asp Arg Asp Ala Glu Asp 
        35                  40                  45              


Gln Asn Arg Tyr Leu Asp Gly Met Asp Ser Asp Phe Thr Ser Met Thr 
    50                  55                  60                  


Ser Leu Leu Thr Gly Ser Val Lys Arg Phe Ser Thr Met Ala Arg Ser 
65                  70                  75                  80  


Gly Gln Asp Asn Arg Lys Leu Leu Cys Gly Met Ala Val Gly Leu Ile 
                85                  90                  95      


Val Ala Phe Phe Ile Leu Ser Tyr Phe Leu Ser Arg Ala Arg Thr 
            100                 105                 110     


<210>  1146
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  1146

Met Gln Trp Asn Val Pro Arg Thr Val Ser Arg Leu Ala Arg Arg Thr 
1               5                   10                  15      


Cys Leu Glu Pro His Asn Ala Gly Leu Phe Gly His Cys Gln Asn Val 
            20                  25                  30          


Lys Gly Pro Leu Leu Leu Tyr Asn Ala Glu Ser Lys Val Val Leu Val 
        35                  40                  45              


Gln Gly Pro Gln Lys Gln Trp Leu His Leu Ser Ala Ala Gln Cys Val 
    50                  55                  60                  


Ala Lys Glu Arg Arg Pro Leu Asp Ala His Pro Pro Gln Pro Gly Val 
65                  70                  75                  80  


Leu Arg His Lys Gln Gly Lys Gln His Val Ser Phe Arg Arg Val Phe 
                85                  90                  95      


Ser Ser Ser Ala Thr Ala Gln Gly Thr Pro Glu Lys Lys Glu Glu Pro 
            100                 105                 110         


Asp Pro Leu Gln Asp Lys Ser Ile Ser Leu Tyr Gln Arg Phe Lys Lys 
        115                 120                 125             


Thr Phe Arg Gln Tyr Gly Lys Val Leu Ile Pro Val His Leu Ile Thr 
    130                 135                 140                 


Ser Gly Val Trp Phe Gly Thr Phe Tyr Tyr Ala Ala Leu Lys Gly Val 
145                 150                 155                 160 


Asn Val Val Pro Phe Leu Glu Leu Ile Gly Leu Pro Asp Ser Val Val 
                165                 170                 175     


Ser Ile Leu Lys Asn Ser Gln Ser Gly Asn Ala Leu Thr Ala Tyr Ala 
            180                 185                 190         


Leu Phe Lys Ile Ala Thr Pro Ala Arg Tyr Thr Val Thr Leu Gly Gly 
        195                 200                 205             


Thr Ser Val Thr Val Lys Tyr Leu Arg Ser His Gly Tyr Met Ser Thr 
    210                 215                 220                 


Pro Pro Pro Val Lys Glu Tyr Leu Gln Asp Arg Met Glu Glu Thr Lys 
225                 230                 235                 240 


Glu Leu Ile Thr Glu Lys Met Glu Glu Thr Lys Asp Arg Leu Thr Glu 
                245                 250                 255     


Lys Leu Gln Glu Thr Lys Glu Lys Val Ser Phe Lys Lys Lys Val Glu 
            260                 265                 270         


<210>  1147
<211>  2769
<212>  PRT
<213>  Homo sapiens

<400>  1147

Met Asp Val Lys Glu Arg Lys Pro Tyr Arg Ser Leu Thr Arg Arg Arg 
1               5                   10                  15      


Asp Ala Glu Arg Arg Tyr Thr Ser Ser Ser Ala Asp Ser Glu Glu Gly 
            20                  25                  30          


Lys Ala Pro Gln Lys Ser Tyr Ser Ser Ser Glu Thr Leu Lys Ala Tyr 
        35                  40                  45              


Asp Gln Asp Ala Arg Leu Ala Tyr Gly Ser Arg Val Lys Asp Ile Val 
    50                  55                  60                  


Pro Gln Glu Ala Glu Glu Phe Cys Arg Thr Gly Ala Asn Phe Thr Leu 
65                  70                  75                  80  


Arg Glu Leu Gly Leu Glu Glu Val Thr Pro Pro His Gly Thr Leu Tyr 
                85                  90                  95      


Arg Thr Asp Ile Gly Leu Pro His Cys Gly Tyr Ser Met Gly Ala Gly 
            100                 105                 110         


Ser Asp Ala Asp Met Glu Ala Asp Thr Val Leu Ser Pro Glu His Pro 
        115                 120                 125             


Val Arg Leu Trp Gly Arg Ser Thr Arg Ser Gly Arg Ser Ser Cys Leu 
    130                 135                 140                 


Ser Ser Arg Ala Asn Ser Asn Leu Thr Leu Thr Asp Thr Glu His Glu 
145                 150                 155                 160 


Asn Thr Glu Thr Asp His Pro Gly Gly Leu Gln Asn His Ala Arg Leu 
                165                 170                 175     


Arg Thr Pro Pro Pro Pro Leu Ser His Ala His Thr Pro Asn Gln His 
            180                 185                 190         


His Ala Ala Ser Ile Asn Ser Leu Asn Arg Gly Asn Phe Thr Pro Arg 
        195                 200                 205             


Ser Asn Pro Ser Pro Ala Pro Thr Asp His Ser Leu Ser Gly Glu Pro 
    210                 215                 220                 


Pro Ala Gly Gly Ala Gln Glu Pro Ala His Ala Gln Glu Asn Trp Leu 
225                 230                 235                 240 


Leu Asn Ser Asn Ile Pro Leu Glu Thr Arg Asn Leu Gly Lys Gln Pro 
                245                 250                 255     


Phe Leu Gly Thr Leu Gln Asp Asn Leu Ile Glu Met Asp Ile Leu Gly 
            260                 265                 270         


Ala Ser Arg His Asp Gly Ala Tyr Ser Asp Gly His Phe Leu Phe Lys 
        275                 280                 285             


Pro Gly Gly Thr Ser Pro Leu Phe Cys Thr Thr Ser Pro Gly Tyr Pro 
    290                 295                 300                 


Leu Thr Ser Ser Thr Val Tyr Ser Pro Pro Pro Arg Pro Leu Pro Arg 
305                 310                 315                 320 


Ser Thr Phe Ala Arg Pro Ala Phe Asn Leu Lys Lys Pro Ser Lys Tyr 
                325                 330                 335     


Cys Asn Trp Lys Cys Ala Ala Leu Ser Ala Ile Val Ile Ser Ala Thr 
            340                 345                 350         


Leu Val Ile Leu Leu Ala Tyr Phe Val Ala Met His Leu Phe Gly Leu 
        355                 360                 365             


Asn Trp His Leu Gln Pro Met Glu Gly Gln Met Tyr Glu Ile Thr Glu 
    370                 375                 380                 


Asp Thr Ala Ser Ser Trp Pro Val Pro Thr Asp Val Ser Leu Tyr Pro 
385                 390                 395                 400 


Ser Gly Gly Thr Gly Leu Glu Thr Pro Asp Arg Lys Gly Lys Gly Thr 
                405                 410                 415     


Thr Glu Gly Lys Pro Ser Ser Phe Phe Pro Glu Asp Ser Phe Ile Asp 
            420                 425                 430         


Ser Gly Glu Ile Asp Val Gly Arg Arg Ala Ser Gln Lys Ile Pro Pro 
        435                 440                 445             


Gly Thr Phe Trp Arg Ser Gln Val Phe Ile Asp His Pro Val His Leu 
    450                 455                 460                 


Lys Phe Asn Val Ser Leu Gly Lys Ala Ala Leu Val Gly Ile Tyr Gly 
465                 470                 475                 480 


Arg Lys Gly Leu Pro Pro Ser His Thr Gln Phe Asp Phe Val Glu Leu 
                485                 490                 495     


Leu Asp Gly Arg Arg Leu Leu Thr Gln Glu Ala Arg Ser Leu Glu Gly 
            500                 505                 510         


Thr Pro Arg Gln Ser Arg Gly Thr Val Pro Pro Ser Ser His Glu Thr 
        515                 520                 525             


Gly Phe Ile Gln Tyr Leu Asp Ser Gly Ile Trp His Leu Ala Phe Tyr 
    530                 535                 540                 


Asn Asp Gly Lys Glu Ser Glu Val Val Ser Phe Leu Thr Thr Ala Ile 
545                 550                 555                 560 


Glu Ser Val Asp Asn Cys Pro Ser Asn Cys Tyr Gly Asn Gly Asp Cys 
                565                 570                 575     


Ile Ser Gly Thr Cys His Cys Phe Leu Gly Phe Leu Gly Pro Asp Cys 
            580                 585                 590         


Gly Arg Ala Ser Cys Pro Val Leu Cys Ser Gly Asn Gly Gln Tyr Met 
        595                 600                 605             


Lys Gly Arg Cys Leu Cys His Ser Gly Trp Lys Gly Ala Glu Cys Asp 
    610                 615                 620                 


Val Pro Thr Asn Gln Cys Ile Asp Val Ala Cys Ser Asn His Gly Thr 
625                 630                 635                 640 


Cys Ile Thr Gly Thr Cys Ile Cys Asn Pro Gly Tyr Lys Gly Glu Ser 
                645                 650                 655     


Cys Glu Glu Val Asp Cys Met Asp Pro Thr Cys Ser Gly Arg Gly Val 
            660                 665                 670         


Cys Val Arg Gly Glu Cys His Cys Ser Val Gly Trp Gly Gly Thr Asn 
        675                 680                 685             


Cys Glu Thr Pro Arg Ala Thr Cys Leu Asp Gln Cys Ser Gly His Gly 
    690                 695                 700                 


Thr Phe Leu Pro Asp Thr Gly Leu Cys Ser Cys Asp Pro Ser Trp Thr 
705                 710                 715                 720 


Gly His Asp Cys Ser Ile Glu Ile Cys Ala Ala Asp Cys Gly Gly His 
                725                 730                 735     


Gly Val Cys Val Gly Gly Thr Cys Arg Cys Glu Asp Gly Trp Met Gly 
            740                 745                 750         


Ala Ala Cys Asp Gln Arg Ala Cys His Pro Arg Cys Ala Glu His Gly 
        755                 760                 765             


Thr Cys Arg Asp Gly Lys Cys Glu Cys Ser Pro Gly Trp Asn Gly Glu 
    770                 775                 780                 


His Cys Thr Ile Ala His Tyr Leu Asp Arg Val Val Lys Glu Gly Cys 
785                 790                 795                 800 


Pro Gly Leu Cys Asn Gly Asn Gly Arg Cys Thr Leu Asp Leu Asn Gly 
                805                 810                 815     


Trp His Cys Val Cys Gln Leu Gly Trp Arg Gly Ala Gly Cys Asp Thr 
            820                 825                 830         


Ser Met Glu Thr Ala Cys Gly Asp Ser Lys Asp Asn Asp Gly Asp Gly 
        835                 840                 845             


Leu Val Asp Cys Met Asp Pro Asp Cys Cys Leu Gln Pro Leu Cys His 
    850                 855                 860                 


Ile Asn Pro Leu Cys Leu Gly Ser Pro Asn Pro Leu Asp Ile Ile Gln 
865                 870                 875                 880 


Glu Thr Gln Val Pro Val Ser Gln Gln Asn Leu His Ser Phe Tyr Asp 
                885                 890                 895     


Arg Ile Lys Phe Leu Val Gly Arg Asp Ser Thr His Ile Ile Pro Gly 
            900                 905                 910         


Glu Asn Pro Phe Asp Gly Gly His Ala Cys Val Ile Arg Gly Gln Val 
        915                 920                 925             


Met Thr Ser Asp Gly Thr Pro Leu Val Gly Val Asn Ile Ser Phe Val 
    930                 935                 940                 


Asn Asn Pro Leu Phe Gly Tyr Thr Ile Ser Arg Gln Asp Gly Ser Phe 
945                 950                 955                 960 


Asp Leu Val Thr Asn Gly Gly Ile Ser Ile Ile Leu Arg Phe Glu Arg 
                965                 970                 975     


Ala Pro Phe Ile Thr Gln Glu His Thr Leu Trp Leu Pro Trp Asp Arg 
            980                 985                 990         


Phe Phe Val Met Glu Thr Ile Ile  Met Arg His Glu Glu  Asn Glu Ile 
        995                 1000                 1005             


Pro Ser  Cys Asp Leu Ser Asn  Phe Ala Arg Pro Asn  Pro Val Val 
    1010                 1015                 1020             


Ser Pro  Ser Pro Leu Thr Ser  Phe Ala Ser Ser Cys  Ala Glu Lys 
    1025                 1030                 1035             


Gly Pro  Ile Val Pro Glu Ile  Gln Ala Leu Gln Glu  Glu Ile Ser 
    1040                 1045                 1050             


Ile Ser  Gly Cys Lys Met Arg  Leu Ser Tyr Leu Ser  Ser Arg Thr 
    1055                 1060                 1065             


Pro Gly  Tyr Lys Ser Val Leu  Arg Ile Ser Leu Thr  His Pro Thr 
    1070                 1075                 1080             


Ile Pro  Phe Asn Leu Met Lys  Val His Leu Met Val  Ala Val Glu 
    1085                 1090                 1095             


Gly Arg  Leu Phe Arg Lys Trp  Phe Ala Ala Ala Pro  Asp Leu Ser 
    1100                 1105                 1110             


Tyr Tyr  Phe Ile Trp Asp Lys  Thr Asp Val Tyr Asn  Gln Lys Val 
    1115                 1120                 1125             


Phe Gly  Leu Ser Glu Ala Phe  Val Ser Val Gly Tyr  Glu Tyr Glu 
    1130                 1135                 1140             


Ser Cys  Pro Asp Leu Ile Leu  Trp Glu Lys Arg Thr  Thr Val Leu 
    1145                 1150                 1155             


Gln Gly  Tyr Glu Ile Asp Ala  Ser Lys Leu Gly Gly  Trp Ser Leu 
    1160                 1165                 1170             


Asp Lys  His His Ala Leu Asn  Ile Gln Ser Gly Ile  Leu His Lys 
    1175                 1180                 1185             


Gly Asn  Gly Glu Asn Gln Phe  Val Ser Gln Gln Pro  Pro Val Ile 
    1190                 1195                 1200             


Gly Ser  Ile Met Gly Asn Gly  Arg Arg Arg Ser Ile  Ser Cys Pro 
    1205                 1210                 1215             


Ser Cys  Asn Gly Leu Ala Asp  Gly Asn Lys Leu Leu  Ala Pro Val 
    1220                 1225                 1230             


Ala Leu  Thr Cys Gly Ser Asp  Gly Ser Leu Tyr Val  Gly Asp Phe 
    1235                 1240                 1245             


Asn Tyr  Ile Arg Arg Ile Phe  Pro Ser Gly Asn Val  Thr Asn Ile 
    1250                 1255                 1260             


Leu Glu  Leu Arg Asn Lys Asp  Phe Arg His Ser His  Ser Pro Ala 
    1265                 1270                 1275             


His Lys  Tyr Tyr Leu Ala Thr  Asp Pro Met Ser Gly  Ala Val Phe 
    1280                 1285                 1290             


Leu Ser  Asp Ser Asn Ser Arg  Arg Val Phe Lys Ile  Lys Ser Thr 
    1295                 1300                 1305             


Val Val  Val Lys Asp Leu Val  Lys Asn Ser Glu Val  Val Ala Gly 
    1310                 1315                 1320             


Thr Gly  Asp Gln Cys Leu Pro  Phe Asp Asp Thr Arg  Cys Gly Asp 
    1325                 1330                 1335             


Gly Gly  Lys Ala Thr Glu Ala  Thr Leu Thr Asn Pro  Arg Gly Ile 
    1340                 1345                 1350             


Thr Val  Asp Lys Phe Gly Leu  Ile Tyr Phe Val Asp  Gly Thr Met 
    1355                 1360                 1365             


Ile Arg  Arg Ile Asp Gln Asn  Gly Ile Ile Ser Thr  Leu Leu Gly 
    1370                 1375                 1380             


Ser Asn  Asp Leu Thr Ser Ala  Arg Pro Leu Ser Cys  Asp Ser Val 
    1385                 1390                 1395             


Met Asp  Ile Ser Gln Val His  Leu Glu Trp Pro Thr  Asp Leu Ala 
    1400                 1405                 1410             


Ile Asn  Pro Met Asp Asn Ser  Leu Tyr Val Leu Asp  Asn Asn Val 
    1415                 1420                 1425             


Val Leu  Gln Ile Ser Glu Asn  His Gln Val Arg Ile  Val Ala Gly 
    1430                 1435                 1440             


Arg Pro  Met His Cys Gln Val  Pro Gly Ile Asp His  Phe Leu Leu 
    1445                 1450                 1455             


Ser Lys  Val Ala Ile His Ala  Thr Leu Glu Ser Ala  Thr Ala Leu 
    1460                 1465                 1470             


Ala Val  Ser His Asn Gly Val  Leu Tyr Ile Ala Glu  Thr Asp Glu 
    1475                 1480                 1485             


Lys Lys  Ile Asn Arg Ile Arg  Gln Val Thr Thr Ser  Gly Glu Ile 
    1490                 1495                 1500             


Ser Leu  Val Ala Gly Ala Pro  Ser Gly Cys Asp Cys  Lys Asn Asp 
    1505                 1510                 1515             


Ala Asn  Cys Asp Cys Phe Ser  Gly Asp Asp Gly Tyr  Ala Lys Asp 
    1520                 1525                 1530             


Ala Lys  Leu Asn Thr Pro Ser  Ser Leu Ala Val Cys  Ala Asp Gly 
    1535                 1540                 1545             


Glu Leu  Tyr Val Ala Asp Leu  Gly Asn Ile Arg Ile  Arg Phe Ile 
    1550                 1555                 1560             


Arg Lys  Asn Lys Pro Phe Leu  Asn Thr Gln Asn Met  Tyr Glu Leu 
    1565                 1570                 1575             


Ser Ser  Pro Ile Asp Gln Glu  Leu Tyr Leu Phe Asp  Thr Thr Gly 
    1580                 1585                 1590             


Lys His  Leu Tyr Thr Gln Ser  Leu Pro Thr Gly Asp  Tyr Leu Tyr 
    1595                 1600                 1605             


Asn Phe  Thr Tyr Thr Gly Asp  Gly Asp Ile Thr Leu  Ile Thr Asp 
    1610                 1615                 1620             


Asn Asn  Gly Asn Met Val Asn  Val Arg Arg Asp Ser  Thr Gly Met 
    1625                 1630                 1635             


Pro Leu  Trp Leu Val Val Pro  Asp Gly Gln Val Tyr  Trp Val Thr 
    1640                 1645                 1650             


Met Gly  Thr Asn Ser Ala Leu  Lys Ser Val Thr Thr  Gln Gly His 
    1655                 1660                 1665             


Glu Leu  Ala Met Met Thr Tyr  His Gly Asn Ser Gly  Leu Leu Ala 
    1670                 1675                 1680             


Thr Lys  Ser Asn Glu Asn Gly  Trp Thr Thr Phe Tyr  Glu Tyr Asp 
    1685                 1690                 1695             


Ser Phe  Gly Arg Leu Thr Asn  Val Thr Phe Pro Thr  Gly Gln Val 
    1700                 1705                 1710             


Ser Ser  Phe Arg Ser Asp Thr  Asp Ser Ser Val His  Val Gln Val 
    1715                 1720                 1725             


Glu Thr  Ser Ser Lys Asp Asp  Val Thr Ile Thr Thr  Asn Leu Ser 
    1730                 1735                 1740             


Ala Ser  Gly Ala Phe Tyr Thr  Leu Leu Gln Asp Gln  Val Arg Asn 
    1745                 1750                 1755             


Ser Tyr  Tyr Ile Gly Ala Asp  Gly Ser Leu Arg Leu  Leu Leu Ala 
    1760                 1765                 1770             


Asn Gly  Met Glu Val Ala Leu  Gln Thr Glu Pro His  Leu Leu Ala 
    1775                 1780                 1785             


Gly Thr  Val Asn Pro Thr Val  Gly Lys Arg Asn Val  Thr Leu Pro 
    1790                 1795                 1800             


Ile Asp  Asn Gly Leu Asn Leu  Val Glu Trp Arg Gln  Arg Lys Glu 
    1805                 1810                 1815             


Gln Ala  Arg Gly Gln Val Thr  Val Phe Gly Arg Arg  Leu Arg Val 
    1820                 1825                 1830             


His Asn  Arg Asn Leu Leu Ser  Leu Asp Phe Asp Arg  Val Thr Arg 
    1835                 1840                 1845             


Thr Glu  Lys Ile Tyr Asp Asp  His Arg Lys Phe Thr  Leu Arg Ile 
    1850                 1855                 1860             


Leu Tyr  Asp Gln Ala Gly Arg  Pro Ser Leu Trp Ser  Pro Ser Ser 
    1865                 1870                 1875             


Arg Leu  Asn Gly Val Asn Val  Thr Tyr Ser Pro Gly  Gly Tyr Ile 
    1880                 1885                 1890             


Ala Gly  Ile Gln Arg Gly Ile  Met Ser Glu Arg Met  Glu Tyr Asp 
    1895                 1900                 1905             


Gln Ala  Gly Arg Ile Thr Ser  Arg Ile Phe Ala Asp  Gly Lys Thr 
    1910                 1915                 1920             


Trp Ser  Tyr Thr Tyr Leu Glu  Lys Ser Met Val Leu  Leu Leu His 
    1925                 1930                 1935             


Ser Gln  Arg Gln Tyr Ile Phe  Glu Phe Asp Lys Asn  Asp Arg Leu 
    1940                 1945                 1950             


Ser Ser  Val Thr Met Pro Asn  Val Ala Arg Gln Thr  Leu Glu Thr 
    1955                 1960                 1965             


Ile Arg  Ser Val Gly Tyr Tyr  Arg Asn Ile Tyr Gln  Pro Pro Glu 
    1970                 1975                 1980             


Gly Asn  Ala Ser Val Ile Gln  Asp Phe Thr Glu Asp  Gly His Leu 
    1985                 1990                 1995             


Leu His  Thr Phe Tyr Leu Gly  Thr Gly Arg Arg Val  Ile Tyr Lys 
    2000                 2005                 2010             


Tyr Gly  Lys Leu Ser Lys Leu  Ala Glu Thr Leu Tyr  Asp Thr Thr 
    2015                 2020                 2025             


Lys Val  Ser Phe Thr Tyr Asp  Glu Thr Ala Gly Met  Leu Lys Thr 
    2030                 2035                 2040             


Ile Asn  Leu Gln Asn Glu Gly  Phe Thr Cys Thr Ile  Arg Tyr Arg 
    2045                 2050                 2055             


Gln Ile  Gly Pro Leu Ile Asp  Arg Gln Ile Phe Arg  Phe Thr Glu 
    2060                 2065                 2070             


Glu Gly  Met Val Asn Ala Arg  Phe Asp Tyr Asn Tyr  Asp Asn Ser 
    2075                 2080                 2085             


Phe Arg  Val Thr Ser Met Gln  Ala Val Ile Asn Glu  Thr Pro Leu 
    2090                 2095                 2100             


Pro Ile  Asp Leu Tyr Arg Tyr  Asp Asp Val Ser Gly  Lys Thr Glu 
    2105                 2110                 2115             


Gln Phe  Gly Lys Phe Gly Val  Ile Tyr Tyr Asp Ile  Asn Gln Ile 
    2120                 2125                 2130             


Ile Thr  Thr Ala Val Met Thr  His Thr Lys His Phe  Asp Ala Tyr 
    2135                 2140                 2145             


Gly Arg  Met Lys Glu Val Gln  Tyr Glu Ile Phe Arg  Ser Leu Met 
    2150                 2155                 2160             


Tyr Trp  Met Thr Val Gln Tyr  Asp Asn Met Gly Arg  Val Val Lys 
    2165                 2170                 2175             


Lys Glu  Leu Lys Val Gly Pro  Tyr Ala Asn Thr Thr  Arg Tyr Ser 
    2180                 2185                 2190             


Tyr Glu  Tyr Asp Ala Asp Gly  Gln Leu Gln Thr Val  Ser Ile Asn 
    2195                 2200                 2205             


Asp Lys  Pro Leu Trp Arg Tyr  Ser Tyr Asp Leu Asn  Gly Asn Leu 
    2210                 2215                 2220             


His Leu  Leu Ser Pro Gly Asn  Ser Ala Arg Leu Thr  Pro Leu Arg 
    2225                 2230                 2235             


Tyr Asp  Ile Arg Asp Arg Ile  Thr Arg Leu Gly Asp  Val Gln Tyr 
    2240                 2245                 2250             


Lys Met  Asp Glu Asp Gly Phe  Leu Arg Gln Arg Gly  Gly Asp Ile 
    2255                 2260                 2265             


Phe Glu  Tyr Asn Ser Ala Gly  Leu Leu Ile Lys Ala  Tyr Asn Arg 
    2270                 2275                 2280             


Ala Gly  Ser Trp Ser Val Arg  Tyr Arg Tyr Asp Gly  Leu Gly Arg 
    2285                 2290                 2295             


Arg Val  Ser Ser Lys Ser Ser  His Ser His His Leu  Gln Phe Phe 
    2300                 2305                 2310             


Tyr Ala  Asp Leu Thr Asn Pro  Thr Lys Val Thr His  Leu Tyr Asn 
    2315                 2320                 2325             


His Ser  Ser Ser Glu Ile Thr  Ser Leu Tyr Tyr Asp  Leu Gln Gly 
    2330                 2335                 2340             


His Leu  Phe Ala Met Glu Leu  Ser Ser Gly Asp Glu  Phe Tyr Ile 
    2345                 2350                 2355             


Ala Cys  Asp Asn Ile Gly Thr  Pro Leu Ala Val Phe  Ser Gly Thr 
    2360                 2365                 2370             


Gly Leu  Met Ile Lys Gln Ile  Leu Tyr Thr Ala Tyr  Gly Glu Ile 
    2375                 2380                 2385             


Tyr Met  Asp Thr Asn Pro Asn  Phe Gln Ile Ile Ile  Gly Tyr His 
    2390                 2395                 2400             


Gly Gly  Leu Tyr Asp Pro Leu  Thr Lys Leu Val His  Met Gly Arg 
    2405                 2410                 2415             


Arg Asp  Tyr Asp Val Leu Ala  Gly Arg Trp Thr Ser  Pro Asp His 
    2420                 2425                 2430             


Glu Leu  Trp Lys His Leu Ser  Ser Ser Asn Val Met  Pro Phe Asn 
    2435                 2440                 2445             


Leu Tyr  Met Phe Lys Asn Asn  Asn Pro Ile Ser Asn  Ser Gln Asp 
    2450                 2455                 2460             


Ile Lys  Cys Phe Met Thr Asp  Val Asn Ser Trp Leu  Leu Thr Phe 
    2465                 2470                 2475             


Gly Phe  Gln Leu His Asn Val  Ile Pro Gly Tyr Pro  Lys Pro Asp 
    2480                 2485                 2490             


Met Asp  Ala Met Glu Pro Ser  Tyr Glu Leu Ile His  Thr Gln Met 
    2495                 2500                 2505             


Lys Thr  Gln Glu Trp Asp Asn  Ser Lys Ser Ile Leu  Gly Val Gln 
    2510                 2515                 2520             


Cys Glu  Val Gln Lys Gln Leu  Lys Ala Phe Val Thr  Leu Glu Arg 
    2525                 2530                 2535             


Phe Asp  Gln Leu Tyr Gly Ser  Thr Ile Thr Ser Cys  Gln Gln Ala 
    2540                 2545                 2550             


Pro Lys  Thr Lys Lys Phe Ala  Ser Ser Gly Ser Val  Phe Gly Lys 
    2555                 2560                 2565             


Gly Val  Lys Phe Ala Leu Lys  Asp Gly Arg Val Thr  Thr Asp Ile 
    2570                 2575                 2580             


Ile Ser  Val Ala Asn Glu Asp  Gly Arg Arg Val Ala  Ala Ile Leu 
    2585                 2590                 2595             


Asn His  Ala His Tyr Leu Glu  Asn Leu His Phe Thr  Ile Asp Gly 
    2600                 2605                 2610             


Val Asp  Thr His Tyr Phe Val  Lys Pro Gly Pro Ser  Glu Gly Asp 
    2615                 2620                 2625             


Leu Ala  Ile Leu Gly Leu Ser  Gly Gly Arg Arg Thr  Leu Glu Asn 
    2630                 2635                 2640             


Gly Val  Asn Val Thr Val Ser  Gln Ile Asn Thr Val  Leu Asn Gly 
    2645                 2650                 2655             


Arg Thr  Arg Arg Tyr Thr Asp  Ile Gln Leu Gln Tyr  Gly Ala Leu 
    2660                 2665                 2670             


Cys Leu  Asn Thr Arg Tyr Gly  Thr Thr Leu Asp Glu  Glu Lys Ala 
    2675                 2680                 2685             


Arg Val  Leu Glu Leu Ala Arg  Gln Arg Ala Val Arg  Gln Ala Trp 
    2690                 2695                 2700             


Ala Arg  Glu Gln Gln Arg Leu  Arg Glu Gly Glu Glu  Gly Leu Arg 
    2705                 2710                 2715             


Ala Trp  Thr Glu Gly Glu Lys  Gln Gln Val Leu Ser  Thr Gly Arg 
    2720                 2725                 2730             


Val Gln  Gly Tyr Asp Gly Phe  Phe Val Ile Ser Val  Glu Gln Tyr 
    2735                 2740                 2745             


Pro Glu  Leu Ser Asp Ser Ala  Asn Asn Ile His Phe  Met Arg Gln 
    2750                 2755                 2760             


Ser Glu  Met Gly Arg Arg 
    2765                 


<210>  1148
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  1148

Met Asp Ser Pro Ser Leu Arg Glu Leu Gln Gln Pro Leu Leu Glu Gly 
1               5                   10                  15      


Thr Glu Cys Glu Thr Pro Ala Gln Lys Pro Gly Arg His Glu Leu Gly 
            20                  25                  30          


Ser Pro Leu Arg Glu Ile Ala Phe Ala Glu Ser Leu Arg Gly Leu Gln 
        35                  40                  45              


Phe Leu Ser Pro Pro Leu Pro Ser Val Ser Ala Gly Leu Gly Glu Pro 
    50                  55                  60                  


Arg Pro Pro Asp Val Glu Asp Met Ser Ser Ser Asp Ser Asp Ser Asp 
65                  70                  75                  80  


Trp Asp Gly Gly Ser Arg Leu Ser Pro Phe Leu Pro His Asp His Leu 
                85                  90                  95      


Gly Leu Ala Val Phe Ser Met Leu Cys Cys Phe Trp Pro Val Gly Ile 
            100                 105                 110         


Ala Ala Phe Cys Leu Ala Gln Lys Thr Asn Lys Ala Trp Ala Lys Gly 
        115                 120                 125             


Asp Ile Gln Gly Ala Gly Ala Ala Ser Arg Arg Ala Phe Leu Leu Gly 
    130                 135                 140                 


Val Leu Ala Val Gly Leu Gly Val Cys Thr Tyr Ala Ala Ala Leu Val 
145                 150                 155                 160 


Thr Leu Ala Ala Tyr Leu Ala Ser Arg Asp Pro Pro 
                165                 170         


<210>  1149
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  1149

Met Asp Ser Pro Ser Leu Arg Glu Leu Gln Gln Pro Leu Leu Glu Gly 
1               5                   10                  15      


Thr Glu Cys Glu Thr Pro Ala Gln Lys Pro Gly Arg His Glu Leu Gly 
            20                  25                  30          


Ser Pro Leu Arg Glu Ile Ala Phe Ala Glu Ser Leu Arg Gly Leu Gln 
        35                  40                  45              


Phe Leu Ser Pro Pro Leu Pro Ser Val Ser Ala Gly Leu Gly Glu Pro 
    50                  55                  60                  


Arg Pro Pro Asp Val Glu Asp Met Ser Ser Ser Asp Ser Asp Ser Asp 
65                  70                  75                  80  


Trp Asp Gly Gly Ser Arg Leu Ser Pro Phe Leu Pro His Asp His Leu 
                85                  90                  95      


Gly Leu Ala Val Phe Ser Met Leu Cys Cys Phe Trp Pro Val Gly Ile 
            100                 105                 110         


Ala Ala Phe Cys Leu Ala Gln Lys Thr Arg Pro Ser Cys Pro Tyr Ser 
        115                 120                 125             


Pro His Cys Glu Pro 
    130             


<210>  1150
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  1150

Met Asp Ser Pro Ser Leu Arg Glu Leu Gln Gln Pro Leu Leu Glu Gly 
1               5                   10                  15      


Thr Glu Cys Glu Thr Pro Ala Gln Lys Pro Gly Arg His Glu Leu Gly 
            20                  25                  30          


Ser Pro Leu Arg Glu Ile Ala Phe Ala Glu Ser Leu Arg Gly Leu Gln 
        35                  40                  45              


Phe Leu Ser Pro Pro Leu Pro Ser Val Ser Ala Gly Leu Gly Glu Pro 
    50                  55                  60                  


Arg Pro Pro Asp Val Glu Asp Met Ser Ser Ser Asp Ser Asp Ser Asp 
65                  70                  75                  80  


Trp Asp Gly Gly Ser Arg Leu Ser Pro Phe Leu Pro His Asp His Leu 
                85                  90                  95      


Gly Leu Ala Val Phe Ser Met Leu Cys Cys Phe Trp Pro Val Gly Ile 
            100                 105                 110         


Ala Ala Phe Cys Leu Ala Gln Lys Leu Pro Leu Gln Pro Ser Leu 
        115                 120                 125         


<210>  1151
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  1151

Met Asp Ser Pro Ser Leu Arg Glu Leu Gln Gln Pro Leu Leu Glu Gly 
1               5                   10                  15      


Thr Glu Cys Glu Thr Pro Ala Gln Lys Pro Gly Arg His Glu Leu Gly 
            20                  25                  30          


Ser Pro Leu Arg Glu Ile Ala Phe Ala Glu Ser Leu Arg Gly Leu Gln 
        35                  40                  45              


Phe Leu Ser Pro Pro Leu Pro Ser Val Ser Ala Gly Leu Gly Glu Pro 
    50                  55                  60                  


Arg Pro Pro Asp Val Glu Asp Met Ser Ser Ser Asp Ser Asp Ser Asp 
65                  70                  75                  80  


Trp Asp Gly Gly Ser Arg Leu Ser Pro Phe Leu Pro His Asp His Leu 
                85                  90                  95      


Gly Leu Ala Val Phe Ser Met Leu Cys Cys Phe Trp Pro Val Gly Ile 
            100                 105                 110         


Ala Ala Phe Cys Leu Ala Gln Lys Pro Ser Leu 
        115                 120             


<210>  1152
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  1152

Met Asp Ser Pro Ser Leu Arg Glu Leu Gln Gln Pro Leu Leu Glu Gly 
1               5                   10                  15      


Thr Glu Cys Glu Thr Pro Ala Gln Lys Pro Gly Arg His Glu Leu Gly 
            20                  25                  30          


Ser Pro Leu Arg Glu Ile Ala Phe Ala Glu Ser Leu Arg Gly Leu Gln 
        35                  40                  45              


Phe Leu Ser Pro Pro Leu Pro Ser Val Ser Ala Gly Leu Gly Glu Pro 
    50                  55                  60                  


Arg Pro Pro Asp Val Glu Asp Met Ser Ser Ser Asp Ser Asp Ser Asp 
65                  70                  75                  80  


Trp Asp Gly Gly Ser Arg Leu Ser Pro Phe Leu Pro His Asp His Leu 
                85                  90                  95      


Gly Leu Ala Val Phe Ser Met Leu Cys Cys Phe Trp Pro Val Gly Ile 
            100                 105                 110         


Ala Ala Phe Cys Leu Ala Gln Lys Thr Arg Pro Ser Cys Pro Tyr Ser 
        115                 120                 125             


Pro His Cys Glu Pro 
    130             


<210>  1153
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  1153

Met Ser Ala Ala Pro Ala Ser Asn Gly Val Phe Val Val Ile Pro Pro 
1               5                   10                  15      


Asn Asn Ala Ser Gly Leu Cys Pro Pro Pro Ala Ile Leu Pro Thr Ser 
            20                  25                  30          


Met Cys Gln Pro Pro Gly Ile Met Gln Phe Glu Glu Pro Pro Leu Gly 
        35                  40                  45              


Ala Gln Thr Pro Arg Ala Thr Gln Pro Pro Asp Leu Arg Pro Val Glu 
    50                  55                  60                  


Thr Phe Leu Thr Gly Glu Pro Lys Val Leu Gly Thr Val Gln Ile Leu 
65                  70                  75                  80  


Ile Gly Leu Ile His Leu Gly Phe Gly Ser Val Leu Leu Met Val Arg 
                85                  90                  95      


Arg Gly His Val Gly Ile Phe Phe Ile Glu Gly Gly Val Pro Phe Trp 
            100                 105                 110         


Gly Gly Ala Cys Phe Ile Ile Ser Gly Ser Leu Ser Val Ala Ala Glu 
        115                 120                 125             


Lys Asn His Thr Ser Cys Leu Val Arg Ser Ser Leu Gly Thr Asn Ile 
    130                 135                 140                 


Leu Ser Val Met Ala Ala Phe Ala Gly Thr Ala Ile Leu Leu Met Asp 
145                 150                 155                 160 


Phe Gly Val Thr Asn Arg Asp Val Asp Arg Gly Tyr Leu Ala Val Leu 
                165                 170                 175     


Thr Ile Phe Thr Val Leu Glu Phe Phe Thr Ala Val Ile Ala Met His 
            180                 185                 190         


Phe Gly Cys Gln Ala Ile His Ala Gln Ala Ser Ala Pro Val Ile Phe 
        195                 200                 205             


Leu Pro Asn Ala Phe Ser Ala Asp Phe Asn Ile Pro Ser Pro Ala Ala 
    210                 215                 220                 


Ser Ala Pro Pro Ala Tyr Asp Asn Val Ala Tyr Ala Gln Gly Val Val 
225                 230                 235                 240 


<210>  1154
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  1154

Met Pro Gly Asp Ser Ser Pro Gly Thr Leu Pro Leu Trp Asp Ala Ser 
1               5                   10                  15      


Leu Ser Pro Pro Leu Gly Pro Asp Pro Gly Gly Phe Ser Arg Ala Ser 
            20                  25                  30          


His Ala Gly Asp Lys Ser Arg Pro Pro Ala Pro Glu Leu Gly Ser Pro 
        35                  40                  45              


Gly Ala Val Arg Pro Arg Val Gly Ser Cys Ala Pro Gly Pro Met Glu 
    50                  55                  60                  


Leu Arg Val Ser Asn Thr Ser Cys Glu Asn Gly Ser Leu Leu His Leu 
65                  70                  75                  80  


Tyr Cys Ser Ser Gln Glu Val Leu Cys Gln Ile Val Asn Asp Leu Ser 
                85                  90                  95      


Pro Glu Val Pro Ser Asn Ala Thr Phe His Ser Trp Gln Glu Arg Ile 
            100                 105                 110         


Arg Gln Asn Tyr Gly Phe Tyr Ile Gly Leu Gly Leu Ala Phe Leu Ser 
        115                 120                 125             


Ser Phe Leu Ile Gly Ser Ser Val Ile Leu Lys Lys Lys Gly Leu Leu 
    130                 135                 140                 


Arg Leu Val Ala Thr Gly Ala Thr Arg Ala Val Asp Gly Gly Phe Gly 
145                 150                 155                 160 


Tyr Leu Lys Asp Ala Met Trp Trp Ala Gly Phe Leu Thr Met Ala Ala 
                165                 170                 175     


Gly Glu Val Ala Asn Phe Gly Ala Tyr Ala Phe Ala Pro Ala Thr Val 
            180                 185                 190         


Val Thr Pro Leu Gly Ala Leu Ser Val Leu Ile Ser Ala Ile Leu Ser 
        195                 200                 205             


Ser Tyr Phe Leu Arg Glu Ser Leu Asn Leu Leu Gly Lys Leu Gly Cys 
    210                 215                 220                 


Val Ile Cys Val Ala Gly Ser Thr Val Met Val Ile His Ala Pro Glu 
225                 230                 235                 240 


Glu Glu Lys Val Thr Thr Ile Met Glu Met Ala Ser Lys Met Lys Asp 
                245                 250                 255     


Thr Gly Phe Ile Val Phe Ala Val Leu Leu Leu Val Ser Cys Leu Ile 
            260                 265                 270         


Leu Ile Phe Val Ile Ala Pro Arg Tyr Gly Gln Arg Asn Ile Leu Ile 
        275                 280                 285             


Tyr Ile Ile Ile Cys Ser Val Ile Gly Ala Phe Ser Val Ala Ala Val 
    290                 295                 300                 


Lys Gly Leu Gly Ile Thr Ile Lys Asn Phe Phe Gln Gly Leu Pro Val 
305                 310                 315                 320 


Val Arg His Pro Leu Pro Tyr Ile Leu Ser Leu Ile Leu Ala Leu Ser 
                325                 330                 335     


Leu Ser Thr Gln Val Asn Phe Leu Asn Arg Ala Leu Asp Ile Phe Asn 
            340                 345                 350         


Thr Ser Leu Val Phe Pro Ile Tyr Tyr Val Phe Phe Thr Thr Val Val 
        355                 360                 365             


Val Thr Ser Ser Ile Ile Leu Phe Lys Glu Trp Tyr Ser Met Ser Ala 
    370                 375                 380                 


Val Asp Ile Ala Gly Thr Leu Ser Gly Phe Val Thr Ile Ile Leu Gly 
385                 390                 395                 400 


Val Phe Met Leu His Ala Phe Lys Asp Leu Asp Ile Ser Cys Ala Ser 
                405                 410                 415     


Leu Pro His Met His Lys Asn Pro Pro Pro Ser Pro Ala Pro Glu Pro 
            420                 425                 430         


Thr Val Ile Arg Leu Glu Asp Lys Asn Val Leu Val Asp Asn Ile Glu 
        435                 440                 445             


Leu Ala Ser Thr Ser Ser Pro Glu Glu Lys Pro Lys Val Phe Ile Ile 
    450                 455                 460                 


His Ser 
465     


<210>  1155
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  1155

Met Thr Ser Cys Gly Gln Gln Ser Leu Asn Val Leu Ala Val Leu Phe 
1               5                   10                  15      


Ser Leu Leu Phe Ser Ala Val Leu Ser Ala His Phe Arg Val Cys Glu 
            20                  25                  30          


Pro Tyr Thr Asp His Lys Gly Arg Tyr His Phe Gly Phe His Cys Pro 
        35                  40                  45              


Arg Leu Ser Asp Asn Lys Thr Phe Ile Leu Cys Cys His His Asn Asn 
    50                  55                  60                  


Thr Val Phe Lys Tyr Cys Cys Asn Glu Thr Glu Phe Gln Ala Val Met 
65                  70                  75                  80  


Gln Ala Asn Leu Thr Ala Ser Ser Glu Gly Tyr Met His Asn Asn Tyr 
                85                  90                  95      


Thr Ala Leu Leu Gly Val Trp Ile Tyr Gly Phe Phe Val Leu Met Leu 
            100                 105                 110         


Leu Val Leu Asp Leu Leu Tyr Tyr Ser Ala Met Asn Tyr Asp Ile Cys 
        115                 120                 125             


Lys Val Tyr Leu Ala Arg Trp Gly Ile Gln Gly Arg Trp Met Lys Gln 
    130                 135                 140                 


Asp Pro Arg Arg Trp Gly Asn Pro Ala Arg Ala Pro Arg Pro Gly Gln 
145                 150                 155                 160 


Arg Ala Pro Gln Pro Gln Pro Pro Pro Gly Pro Leu Pro Gln Ala Pro 
                165                 170                 175     


Gln Ala Val His Thr Leu Arg Gly Asp Ala His Ser Pro Pro Leu Met 
            180                 185                 190         


Thr Phe Gln Ser Ser Ser Ala 
        195                 


<210>  1156
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  1156

Met Gln Leu Pro Arg Trp Trp Glu Leu Gly Asp Pro Cys Ala Trp Thr 
1               5                   10                  15      


Gly Gln Gly Arg Gly Thr Arg Arg Met Ser Pro Ala Thr Thr Gly Thr 
            20                  25                  30          


Phe Leu Leu Thr Val Tyr Ser Ile Phe Ser Lys Val His Ser Asp Arg 
        35                  40                  45              


Asn Val Tyr Pro Ser Ala Gly Val Leu Phe Val His Val Leu Glu Arg 
    50                  55                  60                  


Glu Tyr Phe Lys Gly Glu Phe Pro Pro Tyr Pro Lys Pro Gly Glu Ile 
65                  70                  75                  80  


Ser Asn Asp Pro Ile Thr Phe Asn Thr Asn Leu Met Gly Tyr Pro Asp 
                85                  90                  95      


Arg Pro Gly Trp Leu Arg Tyr Ile Gln Arg Thr Pro Tyr Ser Asp Gly 
            100                 105                 110         


Val Leu Tyr Gly Ser Pro Thr Ala Glu Asn Val Gly Lys Pro Thr Ile 
        115                 120                 125             


Ile Glu Ile Thr Ala Tyr Asn Arg Arg Thr Phe Glu Thr Ala Arg His 
    130                 135                 140                 


Asn Leu Ile Ile Asn Ile Met Ser Ala Glu Asp Phe Pro Leu Pro Tyr 
145                 150                 155                 160 


Gln Ala Glu Phe Phe Ile Lys Asn Met Asn Val Glu Glu Met Leu Ala 
                165                 170                 175     


Ser Glu Val Leu Gly Asp Phe Leu Gly Ala Val Lys Asn Val Trp Gln 
            180                 185                 190         


Pro Glu Arg Leu Asn Ala Ile Asn Ile Thr Ser Ala Leu Asp Arg Gly 
        195                 200                 205             


Gly Arg Val Pro Leu Pro Ile Asn Asp Leu Lys Glu Gly Val Tyr Val 
    210                 215                 220                 


Met Val Gly Ala Asp Val Pro Phe Ser Ser Cys Leu Arg Glu Val Glu 
225                 230                 235                 240 


Asn Pro Gln Asn Gln Leu Arg Cys Ser Gln Glu Met Glu Pro Val Ile 
                245                 250                 255     


Thr Cys Asp Lys Lys Phe Arg Thr Gln Phe Tyr Ile Asp Trp Cys Lys 
            260                 265                 270         


Ile Ser Leu Val Asp Lys Thr Lys Gln Val Ser Thr Tyr Gln Glu Val 
        275                 280                 285             


Ile Arg Gly Glu Gly Ile Leu Pro Asp Gly Gly Glu Tyr Lys Pro Pro 
    290                 295                 300                 


Ser Asp Ser Leu Lys Ser Arg Asp Tyr Tyr Thr Asp Phe Leu Ile Thr 
305                 310                 315                 320 


Leu Ala Val Pro Ser Ala Val Ala Leu Val Leu Phe Leu Ile Leu Ala 
                325                 330                 335     


Tyr Ile Met Cys Cys Arg Arg Glu Gly Val Ile Gln Leu Val His His 
            340                 345                 350         


Ser Ala Ile Gln Lys Ser Thr Lys Glu Leu Arg Asp Met Ser Lys Asn 
        355                 360                 365             


Arg Glu Ile Ala Trp Pro Leu Ser Thr Leu Pro Val Phe His Pro Val 
    370                 375                 380                 


Thr Gly Glu Ile Ile Pro Pro Leu His Thr Asp Asn Tyr Asp Ser Thr 
385                 390                 395                 400 


Asn Met Pro Leu Met Gln Thr Gln Gln Asn Leu Pro His Gln Thr Gln 
                405                 410                 415     


Ile Pro Gln Gln Gln Thr Thr Gly Asp Phe Arg Leu Thr Thr Phe Gln 
            420                 425                 430         


Arg Phe Glu Val Asn Gly Ile Pro Glu Glu Arg Lys Leu Thr Glu Ala 
        435                 440                 445             


Met Asn Leu 
    450     


<210>  1157
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  1157

Met Gln Leu Pro Arg Trp Trp Glu Leu Gly Asp Pro Cys Ala Trp Thr 
1               5                   10                  15      


Gly Gln Gly Arg Gly Thr Arg Arg Met Ser Pro Ala Thr Thr Gly Thr 
            20                  25                  30          


Phe Leu Leu Thr Val Tyr Ser Ile Phe Ser Lys Val His Ser Asp Arg 
        35                  40                  45              


Asn Val Tyr Pro Ser Ala Gly Val Leu Phe Val His Val Leu Glu Arg 
    50                  55                  60                  


Glu Tyr Phe Lys Gly Glu Phe Pro Pro Tyr Pro Lys Pro Gly Glu Ile 
65                  70                  75                  80  


Ser Asn Asp Pro Ile Thr Phe Asn Thr Asn Leu Met Gly Tyr Pro Asp 
                85                  90                  95      


Arg Pro Gly Trp Leu Arg Tyr Ile Gln Arg Thr Pro Tyr Ser Asp Gly 
            100                 105                 110         


Val Leu Tyr Gly Ser Pro Thr Ala Glu Asn Val Gly Lys Pro Thr Ile 
        115                 120                 125             


Ile Glu Ile Thr Ala Tyr Asn Arg Arg Thr Phe Glu Thr Ala Arg His 
    130                 135                 140                 


Asn Leu Ile Ile Asn Ile Met Ser Ala Glu Asp Phe Pro Leu Pro Tyr 
145                 150                 155                 160 


Gln Ala Glu Phe Phe Ile Lys Asn Met Asn Val Glu Glu Met Leu Ala 
                165                 170                 175     


Ser Glu Val Leu Gly Asp Phe Leu Gly Ala Val Lys Asn Val Trp Gln 
            180                 185                 190         


Pro Glu Arg Leu Asn Ala Ile Asn Ile Thr Ser Ala Leu Asp Arg Gly 
        195                 200                 205             


Gly Arg Val Pro Leu Pro Ile Asn Asp Leu Lys Glu Gly Val Tyr Val 
    210                 215                 220                 


Met Val Gly Ala Asp Val Pro Phe Ser Ser Cys Leu Arg Glu Val Glu 
225                 230                 235                 240 


Asn Pro Gln Asn Gln Leu Arg Cys Ser Gln Glu Met Glu Pro Val Ile 
                245                 250                 255     


Thr Cys Asp Lys Lys Phe Arg Thr Gln Phe Tyr Ile Asp Trp Cys Lys 
            260                 265                 270         


Ile Ser Leu Val Asp Lys Thr Lys Gln Val Ser Thr Tyr Gln Glu Val 
        275                 280                 285             


Ile Arg Gly Glu Gly Ile Leu Pro Asp Gly Gly Glu Tyr Lys Pro Pro 
    290                 295                 300                 


Ser Asp Ser Leu Lys Ser Arg Asp Tyr Tyr Thr Asp Phe Leu Ile Thr 
305                 310                 315                 320 


Leu Ala Val Pro Ser Ala Val Ala Leu Val Leu Phe Leu Ile Leu Ala 
                325                 330                 335     


Tyr Ile Met Cys Cys Arg Arg Glu Gly Val Glu Lys Arg Asn Met Gln 
            340                 345                 350         


Thr Pro Asp Ile Gln Leu Val His His Ser Ala Ile Gln Lys Ser Thr 
        355                 360                 365             


Lys Glu Leu Arg Asp Met Ser Lys Asn Arg Glu Ile Ala Trp Pro Leu 
    370                 375                 380                 


Ser Thr Leu Pro Val Phe His Pro Val Thr Gly Glu Ile Ile Pro Pro 
385                 390                 395                 400 


Leu His Thr Asp Asn Tyr Asp Ser Thr Asn Met Pro Leu Met Gln Thr 
                405                 410                 415     


Gln Gln Trp Ser Phe Ala Pro Val Ala Gln Ala Gly Val Gln Trp Ser 
            420                 425                 430         


Asp Leu Gly Ser Leu Gln Pro Pro Pro Pro Arg Asn Leu Pro His Gln 
        435                 440                 445             


Thr Gln Ile Pro Gln Gln Gln Thr Thr Gly Lys Trp Tyr Pro 
    450                 455                 460         


<210>  1158
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  1158

Met Gly Ile Gln Val Pro Leu Asn Ala Thr Glu Phe Asn Tyr Leu Cys 
1               5                   10                  15      


Pro Ala Ile Ile Asn Gln Ile Asp Ala Arg Ser Cys Leu Ile His Thr 
            20                  25                  30          


Ser Glu Lys Lys Ala Glu Ile Pro Pro Lys Thr Tyr Ser Leu Gln Ile 
        35                  40                  45              


Ala Trp Val Gly Gly Phe Ile Ala Ile Ser Ile Ile Ser Phe Leu Ser 
    50                  55                  60                  


Leu Leu Gly Val Ile Leu Val Pro Leu Met Asn Arg Val Phe Phe Lys 
65                  70                  75                  80  


Phe Leu Leu Ser Phe Leu Val Ala Leu Ala Val Gly Thr Leu Ser Gly 
                85                  90                  95      


Asp Ala Phe Leu His Leu Leu Pro His Ser His Ala Ser His His His 
            100                 105                 110         


Ser His Ser His Glu Glu Pro Ala Met Glu Met Lys Arg Gly Pro Leu 
        115                 120                 125             


Phe Ser His Leu Ser Ser Gln Asn Ile Glu Glu Ser Ala Tyr Phe Asp 
    130                 135                 140                 


Ser Thr Trp Lys Gly Leu Thr Ala Leu Gly Gly Leu Tyr Phe Met Phe 
145                 150                 155                 160 


Leu Val Glu His Val Leu Thr Leu Ile Lys Gln Phe Lys Asp Lys Lys 
                165                 170                 175     


Lys Lys Asn Gln Lys Lys Pro Glu Asn Asp Asp Asp Val Glu Ile Lys 
            180                 185                 190         


Lys Gln Leu Ser Lys Tyr Glu Ser Gln Leu Ser Thr Asn Glu Glu Lys 
        195                 200                 205             


Val Asp Thr Asp Asp Arg Thr Glu Gly Tyr Leu Arg Ala Asp Ser Gln 
    210                 215                 220                 


Glu Pro Ser His Phe Asp Ser Gln Gln Pro Ala Val Leu Glu Glu Glu 
225                 230                 235                 240 


Glu Val Met Ile Ala His Ala His Pro Gln Glu Val Tyr Asn Glu Tyr 
                245                 250                 255     


Val Pro Arg Gly Cys Lys Asn Lys Cys His Ser His Phe His Asp Thr 
            260                 265                 270         


Leu Gly Gln Ser Asp Asp Leu Ile His His His His Asp Tyr His His 
        275                 280                 285             


Ile Leu His His His His His Gln Asn His His Pro His Ser His Ser 
    290                 295                 300                 


Gln Arg Tyr Ser Arg Glu Glu Leu Lys Asp Ala Gly Val Ala Thr Leu 
305                 310                 315                 320 


Ala Trp Met Val Ile Met Gly Asp Gly Leu His Asn Phe Ser Asp Gly 
                325                 330                 335     


Leu Ala Ile Gly Ala Ala Phe Thr Glu Gly Leu Ser Ser Gly Leu Ser 
            340                 345                 350         


Thr Ser Val Ala Val Phe Cys His Glu Leu Pro His Glu Leu Gly Asp 
        355                 360                 365             


Phe Ala Val Leu Leu Lys Ala Gly Met Thr Val Lys Gln Ala Val Leu 
    370                 375                 380                 


Tyr Asn Ala Leu Ser Ala Met Leu Ala Tyr Leu Gly Met Ala Thr Gly 
385                 390                 395                 400 


Ile Phe Ile Gly His Tyr Ala Glu Asn Val Ser Met Trp Ile Phe Ala 
                405                 410                 415     


Leu Thr Ala Gly Leu Phe Met Tyr Val Ala Leu Val Asp Met Val Ser 
            420                 425                 430         


Phe 
    


<210>  1159
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  1159

Met Gln Asp Glu Asp Gly Tyr Ile Thr Leu Asn Ile Lys Thr Arg Lys 
1               5                   10                  15      


Pro Ala Leu Ile Ser Ala Val Met Gln Arg Asn Tyr Leu Gln Gly Glu 
            20                  25                  30          


Asn Glu Asn Arg Thr Gly Thr Leu Gln Gln Leu Ala Lys Arg Phe Cys 
        35                  40                  45              


Gln Tyr Val Val Lys Gln Ser Glu Leu Lys Gly Thr Phe Lys Gly His 
    50                  55                  60                  


Lys Cys Ser Pro Cys Asp Thr Asn Trp Arg Tyr Tyr Gly Asp Ser Cys 
65                  70                  75                  80  


Tyr Gly Phe Phe Arg His Asn Leu Thr Trp Glu Glu Ser Lys Gln Tyr 
                85                  90                  95      


Cys Thr Asp Met Asn Ala Thr Leu Leu Lys Ile Asp Asn Arg Asn Ile 
            100                 105                 110         


Val Glu Tyr Ile Lys Ala Arg Thr His Leu Ile Arg Trp Val Gly Leu 
        115                 120                 125             


Ser Arg Gln Lys Ser Asn Glu Val Trp Lys Trp Glu Asp Gly Ser Val 
    130                 135                 140                 


Ile Ser Glu Asn Met Phe Glu Phe Leu Glu Asp Gly Lys Gly Asn Met 
145                 150                 155                 160 


Asn Cys Ala Tyr Phe His Asn Gly Lys Met His Pro Thr Phe Cys Glu 
                165                 170                 175     


Asn Lys His Tyr Leu Met Cys Glu Arg Lys Ala Gly Met Thr Lys Val 
            180                 185                 190         


Asp Gln Leu Pro 
        195     


<210>  1160
<211>  1008
<212>  PRT
<213>  Homo sapiens

<400>  1160

Met Glu Thr Cys Ala Gly Pro His Pro Leu Arg Leu Phe Leu Cys Arg 
1               5                   10                  15      


Met Gln Leu Cys Leu Ala Leu Leu Leu Gly Pro Trp Arg Pro Gly Thr 
            20                  25                  30          


Ala Glu Glu Val Ile Leu Leu Asp Ser Lys Ala Ser Gln Ala Glu Leu 
        35                  40                  45              


Gly Trp Thr Ala Leu Pro Ser Asn Gly Trp Glu Glu Ile Ser Gly Val 
    50                  55                  60                  


Asp Glu His Asp Arg Pro Ile Arg Thr Tyr Gln Val Cys Asn Val Leu 
65                  70                  75                  80  


Glu Pro Asn Gln Asp Asn Trp Leu Gln Thr Gly Trp Ile Ser Arg Gly 
                85                  90                  95      


Arg Gly Gln Arg Ile Phe Val Glu Leu Gln Phe Thr Leu Arg Asp Cys 
            100                 105                 110         


Ser Ser Ile Pro Gly Ala Ala Gly Thr Cys Lys Glu Thr Phe Asn Val 
        115                 120                 125             


Tyr Tyr Leu Glu Thr Glu Ala Asp Leu Gly Arg Gly Arg Pro Arg Leu 
    130                 135                 140                 


Gly Gly Ser Arg Pro Arg Lys Ile Asp Thr Ile Ala Ala Asp Glu Ser 
145                 150                 155                 160 


Phe Thr Gln Gly Asp Leu Gly Glu Arg Lys Met Lys Leu Asn Thr Glu 
                165                 170                 175     


Val Arg Glu Ile Gly Pro Leu Ser Arg Arg Gly Phe His Leu Ala Phe 
            180                 185                 190         


Gln Asp Val Gly Ala Cys Val Ala Leu Val Ser Val Arg Val Tyr Tyr 
        195                 200                 205             


Lys Gln Cys Arg Ala Thr Val Arg Gly Leu Ala Thr Phe Pro Ala Thr 
    210                 215                 220                 


Ala Ala Glu Ser Ala Phe Ser Thr Leu Val Glu Val Ala Gly Thr Cys 
225                 230                 235                 240 


Val Ala His Ser Glu Gly Glu Pro Gly Ser Pro Pro Arg Met His Cys 
                245                 250                 255     


Gly Ala Asp Gly Glu Trp Leu Val Pro Val Gly Arg Cys Ser Cys Ser 
            260                 265                 270         


Ala Gly Phe Gln Glu Arg Gly Asp Phe Cys Glu Ala Cys Pro Pro Gly 
        275                 280                 285             


Phe Tyr Lys Val Ser Pro Arg Arg Pro Leu Cys Ser Pro Cys Pro Glu 
    290                 295                 300                 


His Ser Arg Ala Leu Glu Asn Ala Ser Thr Phe Cys Val Cys Gln Asp 
305                 310                 315                 320 


Ser Tyr Ala Arg Ser Pro Thr Asp Pro Pro Ser Ala Ser Cys Thr Arg 
                325                 330                 335     


Pro Pro Ser Ala Pro Arg Asp Leu Gln Tyr Ser Leu Ser Arg Ser Pro 
            340                 345                 350         


Leu Val Leu Arg Leu Arg Trp Leu Pro Pro Ala Asp Ser Gly Gly Arg 
        355                 360                 365             


Ser Asp Val Thr Tyr Ser Leu Leu Cys Leu Arg Cys Gly Arg Glu Gly 
    370                 375                 380                 


Pro Ala Gly Ala Cys Glu Pro Cys Gly Pro Arg Val Ala Phe Leu Pro 
385                 390                 395                 400 


Arg Gln Ala Gly Leu Arg Glu Arg Ala Ala Thr Leu Leu His Leu Arg 
                405                 410                 415     


Pro Gly Ala Arg Tyr Thr Val Arg Val Ala Ala Leu Asn Gly Val Ser 
            420                 425                 430         


Gly Pro Ala Ala Ala Ala Gly Thr Thr Tyr Ala Gln Val Thr Val Ser 
        435                 440                 445             


Thr Gly Pro Gly Ala Pro Trp Glu Glu Asp Glu Ile Arg Arg Asp Arg 
    450                 455                 460                 


Val Glu Pro Gln Ser Val Ser Leu Ser Trp Arg Glu Pro Ile Pro Ala 
465                 470                 475                 480 


Gly Ala Pro Gly Ala Asn Asp Thr Glu Tyr Glu Ile Arg Tyr Tyr Glu 
                485                 490                 495     


Lys Gly Gln Ser Glu Gln Thr Tyr Ser Met Val Lys Thr Gly Ala Pro 
            500                 505                 510         


Thr Val Thr Val Thr Asn Leu Lys Pro Ala Thr Arg Tyr Val Phe Gln 
        515                 520                 525             


Ile Arg Ala Ala Ser Pro Gly Pro Ser Trp Glu Ala Gln Ser Phe Asn 
    530                 535                 540                 


Pro Ser Ile Glu Val Gln Thr Leu Gly Glu Ala Ala Ser Gly Ser Arg 
545                 550                 555                 560 


Asp Gln Ser Pro Ala Ile Val Val Thr Val Val Thr Ile Ser Ala Leu 
                565                 570                 575     


Leu Val Leu Gly Ser Val Met Ser Val Leu Ala Ile Trp Arg Arg Pro 
            580                 585                 590         


Cys Ser Tyr Gly Lys Gly Gly Gly Asp Ala His Asp Glu Glu Glu Leu 
        595                 600                 605             


Tyr Phe His Phe Lys Val Pro Thr Arg Arg Thr Phe Leu Asp Pro Gln 
    610                 615                 620                 


Ser Cys Gly Asp Leu Leu Gln Ala Val His Leu Phe Ala Lys Glu Leu 
625                 630                 635                 640 


Asp Ala Lys Ser Val Thr Leu Glu Arg Ser Leu Gly Gly Gly Arg Phe 
                645                 650                 655     


Gly Glu Leu Cys Cys Gly Cys Leu Gln Leu Pro Gly Arg Gln Glu Leu 
            660                 665                 670         


Leu Val Ala Val His Met Leu Arg Asp Ser Ala Ser Asp Ser Gln Arg 
        675                 680                 685             


Leu Gly Phe Leu Ala Glu Ala Leu Thr Leu Gly Gln Phe Asp His Ser 
    690                 695                 700                 


His Ile Val Arg Leu Glu Gly Val Val Thr Arg Gly Ser Thr Leu Met 
705                 710                 715                 720 


Ile Val Thr Glu Tyr Met Ser His Gly Ala Leu Asp Gly Phe Leu Arg 
                725                 730                 735     


Arg His Glu Gly Gln Leu Val Ala Gly Gln Leu Met Gly Leu Leu Pro 
            740                 745                 750         


Gly Leu Ala Ser Ala Met Lys Tyr Leu Ser Glu Met Gly Tyr Val His 
        755                 760                 765             


Arg Gly Leu Ala Ala Arg His Val Leu Val Ser Ser Asp Leu Val Cys 
    770                 775                 780                 


Lys Ile Ser Gly Phe Gly Arg Gly Pro Arg Asp Arg Ser Glu Ala Val 
785                 790                 795                 800 


Tyr Thr Thr Met Ser Gly Arg Ser Pro Ala Leu Trp Ala Ala Pro Glu 
                805                 810                 815     


Thr Leu Gln Phe Gly His Phe Ser Ser Ala Ser Asp Val Trp Ser Phe 
            820                 825                 830         


Gly Ile Ile Met Trp Glu Val Met Ala Phe Gly Glu Arg Pro Tyr Trp 
        835                 840                 845             


Asp Met Ser Gly Gln Asp Val Ile Lys Ala Val Glu Asp Gly Phe Arg 
    850                 855                 860                 


Leu Pro Pro Pro Arg Asn Cys Pro Asn Leu Leu His Arg Leu Met Leu 
865                 870                 875                 880 


Asp Cys Trp Gln Lys Asp Pro Gly Glu Arg Pro Arg Phe Ser Gln Ile 
                885                 890                 895     


His Ser Ile Leu Ser Lys Met Val Gln Asp Pro Glu Pro Pro Lys Cys 
            900                 905                 910         


Ala Leu Thr Thr Cys Pro Arg Pro Pro Thr Pro Leu Ala Asp Arg Ala 
        915                 920                 925             


Phe Ser Thr Phe Pro Ser Phe Gly Ser Val Gly Ala Trp Leu Glu Ala 
    930                 935                 940                 


Leu Asp Leu Cys Arg Tyr Lys Asp Ser Phe Ala Ala Ala Gly Tyr Gly 
945                 950                 955                 960 


Ser Leu Glu Ala Val Ala Glu Met Thr Ala Gln Asp Leu Val Ser Leu 
                965                 970                 975     


Gly Ile Ser Leu Ala Glu His Arg Glu Ala Leu Leu Ser Gly Ile Ser 
            980                 985                 990         


Ala Leu Gln Ala Arg Val Leu Gln  Leu Gln Gly Gln Gly  Val Gln Val 
        995                 1000                 1005             


<210>  1161
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  1161

Met Thr Glu Glu Pro Ile Lys Glu Ile Leu Gly Ala Pro Lys Ala His 
1               5                   10                  15      


Met Ala Ala Thr Met Glu Lys Ser Pro Lys Ser Glu Val Val Ile Thr 
            20                  25                  30          


Thr Val Pro Leu Val Ser Glu Ile Gln Leu Met Ala Ala Thr Gly Gly 
        35                  40                  45              


Thr Glu Leu Ser Cys Tyr Arg Cys Ile Ile Pro Phe Ala Val Val Val 
    50                  55                  60                  


Phe Ile Ala Gly Ile Val Val Thr Ala Val Ala Tyr Ser Phe Asn Ser 
65                  70                  75                  80  


His Gly Ser Ile Ile Ser Ile Phe Gly Leu Val Val Leu Ser Ser Gly 
                85                  90                  95      


Leu Phe Leu Leu Ala Ser Ser Ala Leu Cys Trp Lys Val Arg Gln Arg 
            100                 105                 110         


Ser Lys Lys Ala Lys Arg Arg Glu Ser Gln Thr Ala Leu Val Ala Asn 
        115                 120                 125             


Gln Arg Ser Leu Phe Ala 
    130                 


<210>  1162
<211>  566
<212>  PRT
<213>  Homo sapiens

<400>  1162

Met Asp Ser Leu Gln Asp Thr Val Ala Leu Asp His Gly Gly Cys Cys 
1               5                   10                  15      


Pro Ala Leu Ser Arg Leu Val Pro Arg Gly Phe Gly Thr Glu Met Trp 
            20                  25                  30          


Thr Leu Phe Ala Leu Ser Gly Pro Leu Phe Leu Phe Gln Val Leu Thr 
        35                  40                  45              


Phe Met Ile Tyr Ile Val Ser Thr Val Phe Cys Gly His Leu Gly Lys 
    50                  55                  60                  


Val Glu Leu Ala Ser Val Thr Leu Ala Val Ala Phe Val Asn Val Cys 
65                  70                  75                  80  


Gly Val Ser Val Gly Val Gly Leu Ser Ser Ala Cys Asp Thr Leu Met 
                85                  90                  95      


Ser Gln Ser Phe Gly Ser Pro Asn Lys Lys His Val Gly Val Ile Leu 
            100                 105                 110         


Gln Arg Gly Ala Leu Val Leu Leu Leu Cys Cys Leu Pro Cys Trp Ala 
        115                 120                 125             


Leu Phe Leu Asn Thr Gln His Ile Leu Leu Leu Phe Arg Gln Asp Pro 
    130                 135                 140                 


Asp Val Ser Arg Leu Thr Gln Asp Tyr Val Met Ile Phe Ile Pro Gly 
145                 150                 155                 160 


Leu Pro Val Ile Phe Leu Tyr Asn Leu Leu Ala Lys Tyr Leu Gln Asn 
                165                 170                 175     


Gln Lys Ile Thr Trp Pro Gln Val Leu Ser Gly Val Val Gly Asn Cys 
            180                 185                 190         


Val Asn Gly Val Ala Asn Tyr Ala Leu Val Ser Val Leu Asn Leu Gly 
        195                 200                 205             


Val Arg Gly Ser Ala Tyr Ala Asn Ile Ile Ser Gln Phe Ala Gln Thr 
    210                 215                 220                 


Val Phe Leu Leu Leu Tyr Ile Val Leu Lys Lys Leu His Leu Glu Thr 
225                 230                 235                 240 


Trp Ala Gly Trp Ser Ser Gln Cys Leu Gln Asp Trp Gly Pro Phe Phe 
                245                 250                 255     


Ser Leu Ala Val Pro Ser Met Leu Met Ile Cys Val Glu Trp Trp Ala 
            260                 265                 270         


Tyr Glu Ile Gly Ser Phe Leu Met Gly Leu Leu Ser Val Val Asp Leu 
        275                 280                 285             


Ser Ala Gln Ala Val Ile Tyr Glu Val Ala Thr Val Thr Tyr Met Ile 
    290                 295                 300                 


Pro Leu Gly Leu Ser Ile Gly Val Cys Val Arg Val Gly Met Ala Leu 
305                 310                 315                 320 


Gly Ala Ala Asp Thr Val Gln Ala Lys Arg Ser Ala Val Ser Gly Val 
                325                 330                 335     


Leu Ser Ile Val Gly Ile Ser Leu Val Leu Gly Thr Leu Ile Ser Ile 
            340                 345                 350         


Leu Lys Asn Gln Leu Gly His Ile Phe Thr Asn Asp Glu Asp Val Ile 
        355                 360                 365             


Ala Leu Val Ser Gln Val Leu Pro Val Tyr Ser Val Phe His Val Phe 
    370                 375                 380                 


Glu Ala Ile Cys Cys Val Tyr Gly Gly Val Leu Arg Gly Thr Gly Lys 
385                 390                 395                 400 


Gln Ala Phe Gly Ala Ala Val Asn Ala Ile Thr Tyr Tyr Ile Ile Gly 
                405                 410                 415     


Leu Pro Leu Gly Ile Leu Leu Thr Phe Val Val Arg Met Arg Ile Met 
            420                 425                 430         


Gly Leu Trp Leu Gly Met Leu Ala Cys Val Phe Leu Ala Thr Ala Ala 
        435                 440                 445             


Phe Val Ala Tyr Thr Ala Arg Leu Asp Trp Lys Leu Ala Ala Glu Glu 
    450                 455                 460                 


Ala Lys Lys His Ser Gly Arg Gln Gln Gln Gln Arg Ala Glu Ser Thr 
465                 470                 475                 480 


Ala Thr Arg Pro Gly Pro Glu Lys Ala Val Leu Ser Ser Val Ala Thr 
                485                 490                 495     


Gly Ser Ser Pro Gly Ile Thr Leu Thr Thr Tyr Ser Arg Ser Glu Cys 
            500                 505                 510         


His Val Asp Phe Phe Arg Thr Pro Glu Glu Ala His Ala Leu Ser Ala 
        515                 520                 525             


Pro Thr Ser Arg Leu Ser Val Lys Gln Leu Val Ile Arg Arg Gly Ala 
    530                 535                 540                 


Ala Leu Gly Ala Ala Ser Ala Thr Leu Met Val Gly Leu Thr Val Arg 
545                 550                 555                 560 


Ile Leu Ala Thr Arg His 
                565     


<210>  1163
<211>  409
<212>  PRT
<213>  Homo sapiens

<400>  1163

Met Arg Arg Tyr Leu Arg Val Val Val Leu Cys Val Ala Cys Gly Phe 
1               5                   10                  15      


Cys Ser Leu Leu Tyr Ala Phe Ser Gln Leu Ala Val Ser Leu Glu Glu 
            20                  25                  30          


Gly Thr Gly Gly Gly Gly Gly Lys Pro Gln Ala Ala Val Ala Ser Trp 
        35                  40                  45              


Leu Ala Gly Gly Gly Arg Gly Ala Val Arg Gly Ala Gly Val Ala Gly 
    50                  55                  60                  


Pro Ala Ala His Pro Gly Val Ser Asp Arg Tyr Ser Leu Lys Ile Gln 
65                  70                  75                  80  


Pro Val Glu Lys Met His Leu Ala Val Val Ala Cys Gly Glu Arg Leu 
                85                  90                  95      


Glu Glu Thr Met Thr Met Leu Lys Ser Ala Ile Ile Phe Ser Ile Lys 
            100                 105                 110         


Pro Leu Gln Phe His Ile Phe Ala Glu Asp Gln Leu His His Ser Phe 
        115                 120                 125             


Lys Gly Arg Leu Asp Asn Trp Ser Phe Leu Gln Thr Phe Asn Tyr Thr 
    130                 135                 140                 


Leu Tyr Pro Ile Thr Phe Pro Ser Glu Asn Ala Ala Glu Trp Lys Lys 
145                 150                 155                 160 


Leu Phe Lys Pro Cys Ala Ser Gln Arg Leu Phe Leu Pro Leu Ile Leu 
                165                 170                 175     


Lys Glu Val Asp Ser Leu Leu Tyr Val Asp Thr Asp Ile Leu Phe Leu 
            180                 185                 190         


Arg Pro Val Asp Asp Ile Trp Ser Leu Leu Lys Lys Phe Asn Ser Thr 
        195                 200                 205             


Gln Ile Ala Ala Met Ala Pro Glu His Glu Glu Pro Arg Ile Gly Trp 
    210                 215                 220                 


Tyr Asn Arg Phe Ala Arg His Pro Tyr Tyr Gly Lys Thr Gly Val Asn 
225                 230                 235                 240 


Ser Gly Val Met Leu Met Asn Met Thr Arg Met Arg Arg Lys Tyr Phe 
                245                 250                 255     


Lys Asn Asp Met Thr Thr Val Arg Leu Gln Trp Gly Asp Ile Leu Met 
            260                 265                 270         


Pro Leu Leu Lys Lys Tyr Lys Leu Asn Ile Thr Trp Gly Asp Gln Asp 
        275                 280                 285             


Leu Leu Asn Ile Val Phe Phe His Asn Pro Glu Ser Leu Phe Val Phe 
    290                 295                 300                 


Pro Cys Gln Trp Asn Tyr Arg Pro Asp His Cys Ile Tyr Gly Ser Asn 
305                 310                 315                 320 


Cys Gln Glu Ala Glu Glu Gly Gly Ile Phe Ile Leu His Gly Asn Arg 
                325                 330                 335     


Gly Val Tyr His Asp Asp Lys Gln Pro Ala Phe Arg Ala Val Tyr Glu 
            340                 345                 350         


Ala Leu Arg Asn Cys Ser Phe Glu Asp Asp Asn Ile Arg Ser Leu Leu 
        355                 360                 365             


Lys Pro Leu Glu Leu Glu Leu Gln Lys Thr Val His Thr Tyr Cys Gly 
    370                 375                 380                 


Lys Ile Tyr Lys Ile Phe Ile Lys Gln Leu Ala Lys Ser Val Arg Asp 
385                 390                 395                 400 


Arg Tyr Ala Arg Ser Pro Lys Glu Lys 
                405                 


<210>  1164
<211>  429
<212>  PRT
<213>  Homo sapiens

<400>  1164

Met Arg Val Ser Val Pro Gly Pro Ala Ala Ala Ala Ala Pro Ala Ala 
1               5                   10                  15      


Gly Arg Glu Pro Ser Thr Pro Gly Gly Gly Ser Gly Gly Gly Gly Ala 
            20                  25                  30          


Val Ala Ala Ala Ser Gly Ala Ala Val Pro Gly Ser Val Gln Leu Ala 
        35                  40                  45              


Leu Ser Val Leu His Ala Leu Leu Tyr Ala Ala Leu Phe Ala Phe Ala 
    50                  55                  60                  


Tyr Leu Gln Leu Trp Arg Leu Leu Leu Tyr Arg Glu Arg Arg Leu Ser 
65                  70                  75                  80  


Tyr Gln Ser Leu Cys Leu Phe Leu Cys Leu Leu Trp Ala Ala Leu Arg 
                85                  90                  95      


Thr Thr Leu Phe Ser Ala Ala Phe Ser Leu Ser Gly Ser Leu Pro Leu 
            100                 105                 110         


Leu Arg Pro Pro Ala His Leu His Phe Phe Pro His Trp Leu Leu Tyr 
        115                 120                 125             


Cys Phe Pro Ser Cys Leu Gln Phe Ser Thr Leu Cys Leu Leu Asn Leu 
    130                 135                 140                 


Tyr Leu Ala Glu Val Ile Cys Lys Val Arg Cys Ala Thr Glu Leu Asp 
145                 150                 155                 160 


Arg His Lys Ile Leu Leu His Leu Gly Phe Ile Met Ala Ser Leu Leu 
                165                 170                 175     


Phe Leu Val Val Asn Leu Thr Cys Ala Met Leu Val His Gly Asp Val 
            180                 185                 190         


Pro Glu Asn Gln Leu Lys Trp Thr Val Phe Val Arg Ala Leu Ile Asn 
        195                 200                 205             


Asp Ser Leu Phe Ile Leu Cys Ala Ile Ser Leu Val Cys Tyr Ile Cys 
    210                 215                 220                 


Lys Ile Thr Lys Met Ser Ser Ala Asn Val Tyr Leu Glu Ser Lys Gly 
225                 230                 235                 240 


Met Ser Leu Cys Gln Thr Val Val Val Gly Ser Val Val Ile Leu Leu 
                245                 250                 255     


Tyr Ser Ser Arg Ala Cys Tyr Asn Leu Val Val Val Thr Ile Ser Gln 
            260                 265                 270         


Asp Thr Leu Glu Ser Pro Phe Asn Tyr Gly Trp Asp Asn Leu Ser Asp 
        275                 280                 285             


Lys Ala His Val Glu Asp Ile Ser Gly Glu Glu Tyr Ile Val Phe Gly 
    290                 295                 300                 


Met Val Leu Phe Leu Trp Glu His Val Pro Ala Trp Ser Val Val Leu 
305                 310                 315                 320 


Phe Phe Arg Ala Gln Arg Leu Asn Gln Asn Leu Ala Pro Ala Gly Met 
                325                 330                 335     


Ile Asn Ser His Ser Tyr Ser Ser Arg Ala Tyr Phe Phe Asp Asn Pro 
            340                 345                 350         


Arg Arg Tyr Asp Ser Asp Asp Asp Leu Pro Arg Leu Gly Ser Ser Arg 
        355                 360                 365             


Glu Gly Ser Leu Pro Asn Ser Gln Ser Leu Gly Trp Tyr Gly Thr Met 
    370                 375                 380                 


Thr Gly Cys Gly Ser Ser Ser Tyr Thr Val Thr Pro His Leu Asn Gly 
385                 390                 395                 400 


Pro Met Thr Asp Thr Ala Pro Leu Leu Phe Thr Cys Ser Asn Leu Asp 
                405                 410                 415     


Leu Asn Asn His His Ser Leu Tyr Val Thr Pro Gln Asn 
            420                 425                 


<210>  1165
<211>  708
<212>  PRT
<213>  Homo sapiens

<400>  1165

Met Lys Asp Met Pro Leu Arg Ile His Val Leu Leu Gly Leu Ala Ile 
1               5                   10                  15      


Thr Thr Leu Val Gln Ala Val Asp Lys Lys Val Asp Cys Pro Arg Leu 
            20                  25                  30          


Cys Thr Cys Glu Ile Arg Pro Trp Phe Thr Pro Arg Ser Ile Tyr Met 
        35                  40                  45              


Glu Ala Ser Thr Val Asp Cys Asn Asp Leu Gly Leu Leu Thr Phe Pro 
    50                  55                  60                  


Ala Arg Leu Pro Ala Asn Thr Gln Ile Leu Leu Leu Gln Thr Asn Asn 
65                  70                  75                  80  


Ile Ala Lys Ile Glu Tyr Ser Thr Asp Phe Pro Val Asn Leu Thr Gly 
                85                  90                  95      


Leu Asp Leu Ser Gln Asn Asn Leu Ser Ser Val Thr Asn Ile Asn Val 
            100                 105                 110         


Lys Lys Met Pro Gln Leu Leu Ser Val Tyr Leu Glu Glu Asn Lys Leu 
        115                 120                 125             


Thr Glu Leu Pro Glu Lys Cys Leu Ser Glu Leu Ser Asn Leu Gln Glu 
    130                 135                 140                 


Leu Tyr Ile Asn His Asn Leu Leu Ser Thr Ile Ser Pro Gly Ala Phe 
145                 150                 155                 160 


Ile Gly Leu His Asn Leu Leu Arg Leu His Leu Asn Ser Asn Arg Leu 
                165                 170                 175     


Gln Met Ile Asn Ser Lys Trp Phe Asp Ala Leu Pro Asn Leu Glu Ile 
            180                 185                 190         


Leu Met Ile Gly Glu Asn Pro Ile Ile Arg Ile Lys Asp Met Asn Phe 
        195                 200                 205             


Lys Pro Leu Ile Asn Leu Arg Ser Leu Val Ile Ala Gly Ile Asn Leu 
    210                 215                 220                 


Thr Glu Ile Pro Asp Asn Ala Leu Val Gly Leu Glu Asn Leu Glu Ser 
225                 230                 235                 240 


Ile Ser Phe Tyr Asp Asn Arg Leu Ile Lys Val Pro His Val Ala Leu 
                245                 250                 255     


Gln Lys Val Val Asn Leu Lys Phe Leu Asp Leu Asn Lys Asn Pro Ile 
            260                 265                 270         


Asn Arg Ile Arg Arg Gly Asp Phe Ser Asn Met Leu His Leu Lys Glu 
        275                 280                 285             


Leu Gly Ile Asn Asn Met Pro Glu Leu Ile Ser Ile Asp Ser Leu Ala 
    290                 295                 300                 


Val Asp Asn Leu Pro Asp Leu Arg Lys Ile Glu Ala Thr Asn Asn Pro 
305                 310                 315                 320 


Arg Leu Ser Tyr Ile His Pro Asn Ala Phe Phe Arg Leu Pro Lys Leu 
                325                 330                 335     


Glu Ser Leu Met Leu Asn Ser Asn Ala Leu Ser Ala Leu Tyr His Gly 
            340                 345                 350         


Thr Ile Glu Ser Leu Pro Asn Leu Lys Glu Ile Ser Ile His Ser Asn 
        355                 360                 365             


Pro Ile Arg Cys Asp Cys Val Ile Arg Trp Met Asn Met Asn Lys Thr 
    370                 375                 380                 


Asn Ile Arg Phe Met Glu Pro Asp Ser Leu Phe Cys Val Asp Pro Pro 
385                 390                 395                 400 


Glu Phe Gln Gly Gln Asn Val Arg Gln Val His Phe Arg Asp Met Met 
                405                 410                 415     


Glu Ile Cys Leu Pro Leu Ile Ala Pro Glu Ser Phe Pro Ser Asn Leu 
            420                 425                 430         


Asn Val Glu Ala Gly Ser Tyr Val Ser Phe His Cys Arg Ala Thr Ala 
        435                 440                 445             


Glu Pro Gln Pro Glu Ile Tyr Trp Ile Thr Pro Ser Gly Gln Lys Leu 
    450                 455                 460                 


Leu Pro Asn Thr Leu Thr Asp Lys Phe Tyr Val His Ser Glu Gly Thr 
465                 470                 475                 480 


Leu Asp Ile Asn Gly Val Thr Pro Lys Glu Gly Gly Leu Tyr Thr Cys 
                485                 490                 495     


Ile Ala Thr Asn Leu Val Gly Ala Asp Leu Lys Ser Val Met Ile Lys 
            500                 505                 510         


Val Asp Gly Ser Phe Pro Gln Asp Asn Asn Gly Ser Leu Asn Ile Lys 
        515                 520                 525             


Ile Arg Asp Ile Gln Ala Asn Ser Val Leu Val Ser Trp Lys Ala Ser 
    530                 535                 540                 


Ser Lys Ile Leu Lys Ser Ser Val Lys Trp Thr Ala Phe Val Lys Thr 
545                 550                 555                 560 


Glu Asn Ser His Ala Ala Gln Ser Ala Arg Ile Pro Ser Asp Val Lys 
                565                 570                 575     


Val Tyr Asn Leu Thr His Leu Asn Pro Ser Thr Glu Tyr Lys Ile Cys 
            580                 585                 590         


Ile Asp Ile Pro Thr Ile Tyr Gln Lys Asn Arg Lys Lys Cys Val Asn 
        595                 600                 605             


Val Thr Thr Lys Gly Leu His Pro Asp Gln Lys Glu Tyr Glu Lys Asn 
    610                 615                 620                 


Asn Thr Thr Thr Leu Met Ala Cys Leu Gly Gly Leu Leu Gly Ile Ile 
625                 630                 635                 640 


Gly Val Ile Cys Leu Ile Ser Cys Leu Ser Pro Glu Met Asn Cys Asp 
                645                 650                 655     


Gly Gly His Ser Tyr Val Arg Asn Tyr Leu Gln Lys Pro Thr Phe Ala 
            660                 665                 670         


Leu Gly Glu Leu Tyr Pro Pro Leu Ile Asn Leu Trp Glu Ala Gly Lys 
        675                 680                 685             


Glu Lys Ser Thr Ser Leu Lys Val Lys Ala Thr Val Ile Gly Leu Pro 
    690                 695                 700                 


Thr Asn Met Ser 
705             


<210>  1166
<211>  708
<212>  PRT
<213>  Homo sapiens

<400>  1166

Met Lys Asp Met Pro Leu Arg Ile His Val Leu Leu Gly Leu Ala Ile 
1               5                   10                  15      


Thr Thr Leu Val Gln Ala Val Asp Lys Lys Val Asp Cys Pro Arg Leu 
            20                  25                  30          


Cys Thr Cys Glu Ile Arg Pro Trp Phe Thr Pro Arg Ser Ile Tyr Met 
        35                  40                  45              


Glu Ala Ser Thr Val Asp Cys Asn Asp Leu Gly Leu Leu Thr Phe Pro 
    50                  55                  60                  


Ala Arg Leu Pro Ala Asn Thr Gln Ile Leu Leu Leu Gln Thr Asn Asn 
65                  70                  75                  80  


Ile Ala Lys Ile Glu Tyr Ser Thr Asp Phe Pro Val Asn Leu Thr Gly 
                85                  90                  95      


Leu Asp Leu Ser Gln Asn Asn Leu Ser Ser Val Thr Asn Ile Asn Val 
            100                 105                 110         


Lys Lys Met Pro Gln Leu Leu Ser Val Tyr Leu Glu Glu Asn Lys Leu 
        115                 120                 125             


Thr Glu Leu Pro Glu Lys Cys Leu Ser Glu Leu Ser Asn Leu Gln Glu 
    130                 135                 140                 


Leu Tyr Ile Asn His Asn Leu Leu Ser Thr Ile Ser Pro Gly Ala Phe 
145                 150                 155                 160 


Ile Gly Leu His Asn Leu Leu Arg Leu His Leu Asn Ser Asn Arg Leu 
                165                 170                 175     


Gln Met Ile Asn Ser Lys Trp Phe Asp Ala Leu Pro Asn Leu Glu Ile 
            180                 185                 190         


Leu Met Ile Gly Glu Asn Pro Ile Ile Arg Ile Lys Asp Met Asn Phe 
        195                 200                 205             


Lys Pro Leu Ile Asn Leu Arg Ser Leu Val Ile Ala Gly Ile Asn Leu 
    210                 215                 220                 


Thr Glu Ile Pro Asp Asn Ala Leu Val Gly Leu Glu Asn Leu Glu Ser 
225                 230                 235                 240 


Ile Ser Phe Tyr Asp Asn Arg Leu Ile Lys Val Pro His Val Ala Leu 
                245                 250                 255     


Gln Lys Val Val Asn Leu Lys Phe Leu Asp Leu Asn Lys Asn Pro Ile 
            260                 265                 270         


Asn Arg Ile Arg Arg Gly Asp Phe Ser Asn Met Leu His Leu Lys Glu 
        275                 280                 285             


Leu Gly Ile Asn Asn Met Pro Glu Leu Ile Ser Ile Asp Ser Leu Ala 
    290                 295                 300                 


Val Asp Asn Leu Pro Asp Leu Arg Lys Ile Glu Ala Thr Asn Asn Pro 
305                 310                 315                 320 


Arg Leu Ser Tyr Ile His Pro Asn Ala Phe Phe Arg Leu Pro Lys Leu 
                325                 330                 335     


Glu Ser Leu Met Leu Asn Ser Asn Ala Leu Ser Ala Leu Tyr His Gly 
            340                 345                 350         


Thr Ile Glu Ser Leu Pro Asn Leu Lys Glu Ile Ser Ile His Ser Asn 
        355                 360                 365             


Pro Ile Arg Cys Asp Cys Val Ile Arg Trp Met Asn Met Asn Lys Thr 
    370                 375                 380                 


Asn Ile Arg Phe Met Glu Pro Asp Ser Leu Phe Cys Val Asp Pro Pro 
385                 390                 395                 400 


Glu Phe Gln Gly Gln Asn Val Arg Gln Val His Phe Arg Asp Met Met 
                405                 410                 415     


Glu Ile Cys Leu Pro Leu Ile Ala Pro Glu Ser Phe Pro Ser Asn Leu 
            420                 425                 430         


Asn Val Glu Ala Gly Ser Tyr Val Ser Phe His Cys Arg Ala Thr Ala 
        435                 440                 445             


Glu Pro Gln Pro Glu Ile Tyr Trp Ile Thr Pro Ser Gly Gln Lys Leu 
    450                 455                 460                 


Leu Pro Asn Thr Leu Thr Asp Lys Phe Tyr Val His Ser Glu Gly Thr 
465                 470                 475                 480 


Leu Asp Ile Asn Gly Val Thr Pro Lys Glu Gly Gly Leu Tyr Thr Cys 
                485                 490                 495     


Ile Ala Thr Asn Leu Val Gly Ala Asp Leu Lys Ser Val Met Ile Lys 
            500                 505                 510         


Val Asp Gly Ser Phe Pro Gln Asp Asn Asn Gly Ser Leu Asn Ile Lys 
        515                 520                 525             


Ile Arg Asp Ile Gln Ala Asn Ser Val Leu Val Ser Trp Lys Ala Ser 
    530                 535                 540                 


Ser Lys Ile Leu Lys Ser Ser Val Lys Trp Thr Ala Phe Val Lys Thr 
545                 550                 555                 560 


Glu Asn Ser His Ala Ala Gln Ser Ala Arg Ile Pro Ser Asp Val Lys 
                565                 570                 575     


Val Tyr Asn Leu Thr His Leu Asn Pro Ser Thr Glu Tyr Lys Ile Cys 
            580                 585                 590         


Ile Asp Ile Pro Thr Ile Tyr Gln Lys Asn Arg Lys Lys Cys Val Asn 
        595                 600                 605             


Val Thr Thr Lys Gly Leu His Pro Asp Gln Lys Glu Tyr Glu Lys Asn 
    610                 615                 620                 


Asn Thr Thr Thr Leu Met Ala Cys Leu Gly Gly Leu Leu Gly Ile Ile 
625                 630                 635                 640 


Gly Val Ile Cys Leu Ile Ser Cys Leu Ser Pro Glu Met Asn Cys Asp 
                645                 650                 655     


Gly Gly His Ser Tyr Val Arg Asn Tyr Leu Gln Lys Pro Thr Phe Ala 
            660                 665                 670         


Leu Gly Glu Leu Tyr Pro Pro Leu Ile Asn Leu Trp Glu Ala Gly Lys 
        675                 680                 685             


Glu Lys Ser Thr Ser Leu Lys Val Lys Ala Thr Val Ile Gly Leu Pro 
    690                 695                 700                 


Thr Asn Met Ser 
705             


<210>  1167
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  1167

Met Met Tyr Arg Pro Asp Val Val Arg Ala Arg Lys Arg Val Cys Trp 
1               5                   10                  15      


Glu Pro Trp Val Ile Gly Leu Val Ile Phe Ile Ser Leu Ile Val Leu 
            20                  25                  30          


Ala Val Cys Ile Gly Leu Thr Val His Tyr Val Arg Tyr Asn Gln Lys 
        35                  40                  45              


Lys Thr Tyr Asn Tyr Tyr Ser Thr Leu Ser Phe Thr Thr Asp Lys Leu 
    50                  55                  60                  


Tyr Ala Glu Phe Gly Arg Glu Ala Ser Asn Asn Phe Thr Glu Met Ser 
65                  70                  75                  80  


Gln Arg Leu Glu Ser Met Val Lys Asn Ala Phe Tyr Lys Ser Pro Leu 
                85                  90                  95      


Arg Glu Glu Phe Val Lys Ser Gln Val Ile Lys Phe Ser Gln Gln Lys 
            100                 105                 110         


His Gly Val Leu Ala His Met Leu Leu Ile Cys Arg Phe His Ser Thr 
        115                 120                 125             


Glu Asp Pro Glu Thr Val Asp Lys Ile Val Gln Leu Val Leu His Glu 
    130                 135                 140                 


Lys Leu Gln Asp Ala Val Gly Pro Pro Lys Val Asp Pro His Ser Val 
145                 150                 155                 160 


Lys Ile Lys Lys Ile Asn Lys Thr Glu Thr Asp Ser Tyr Leu Asn His 
                165                 170                 175     


Cys Cys Gly Thr Arg Arg Ser Lys Thr Leu Gly Gln Ser Leu Arg Ile 
            180                 185                 190         


Val Gly Gly Thr Glu Val Glu Glu Gly Glu Trp Pro Trp Gln Ala Ser 
        195                 200                 205             


Leu Gln Trp Asp Gly Ser His Arg Cys Gly Ala Thr Leu Ile Asn Ala 
    210                 215                 220                 


Thr Trp Leu Val Ser Ala Ala His Cys Phe Thr Thr Tyr Lys Asn Pro 
225                 230                 235                 240 


Ala Arg Trp Thr Ala Ser Phe Gly Val Thr Ile Lys Pro Ser Lys Met 
                245                 250                 255     


Lys Arg Gly Leu Arg Arg Ile Ile Val His Glu Lys Tyr Lys His Pro 
            260                 265                 270         


Ser His Asp Tyr Asp Ile Ser Leu Ala Glu Leu Ser Ser Pro Val Pro 
        275                 280                 285             


Tyr Thr Asn Ala Val His Arg Val Cys Leu Pro Asp Ala Ser Tyr Glu 
    290                 295                 300                 


Phe Gln Pro Gly Asp Val Met Phe Val Thr Gly Phe Gly Ala Leu Lys 
305                 310                 315                 320 


Asn Asp Gly Tyr Ser Gln Asn His Leu Arg Gln Ala Gln Val Thr Leu 
                325                 330                 335     


Ile Asp Ala Thr Thr Cys Asn Glu Pro Gln Ala Tyr Asn Asp Ala Ile 
            340                 345                 350         


Thr Pro Arg Met Leu Cys Ala Gly Ser Leu Glu Gly Lys Thr Asp Ala 
        355                 360                 365             


Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Ser Ser Asp Ala Arg Asp 
    370                 375                 380                 


Ile Trp Tyr Leu Ala Gly Ile Val Ser Trp Gly Asp Glu Cys Ala Lys 
385                 390                 395                 400 


Pro Asn Lys Pro Gly Val Tyr Thr Arg Val Thr Ala Leu Arg Asp Trp 
                405                 410                 415     


Ile Thr Ser Lys Thr Gly Ile 
            420             


<210>  1168
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  1168

Met Glu Gln Lys Leu Val Glu Glu Ile Leu Gln Ala Ile Thr Met Ser 
1               5                   10                  15      


Thr Asp Thr Gly Val Ser Leu Pro Ser Tyr Glu Glu Asp Gln Gly Ser 
            20                  25                  30          


Lys Leu Ile Arg Lys Ala Lys Glu Ala Pro Phe Val Pro Val Gly Ile 
        35                  40                  45              


Ala Gly Phe Ala Ala Ile Val Ala Tyr Gly Leu Tyr Lys Leu Lys Ser 
    50                  55                  60                  


Arg Gly Asn Thr Lys Met Ser Ile His Leu Ile His Met Arg Val Ala 
65                  70                  75                  80  


Ala Gln Gly Phe Val Val Gly Ala Met Thr Val Gly Met Gly Tyr Ser 
                85                  90                  95      


Met Tyr Arg Glu Phe Trp Ala Lys Pro Lys Pro 
            100                 105         


<210>  1169
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  1169

Met Ser Thr Asp Thr Gly Val Ser Leu Pro Ser Tyr Glu Glu Asp Gln 
1               5                   10                  15      


Gly Ser Lys Leu Ile Arg Lys Ala Lys Glu Ala Pro Phe Val Pro Val 
            20                  25                  30          


Gly Ile Ala Gly Phe Ala Ala Ile Val Ala Tyr Gly Leu Tyr Lys Leu 
        35                  40                  45              


Lys Ser Arg Gly Asn Thr Lys Met Ser Ile His Leu Ile His Met Arg 
    50                  55                  60                  


Val Ala Ala Gln Gly Phe Val Val Gly Ala Met Thr Val Gly Met Gly 
65                  70                  75                  80  


Tyr Ser Met Tyr Arg Glu Phe Trp Ala Lys Pro Lys Pro 
                85                  90              


<210>  1170
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  1170

Met Val Pro Ser Ala Gly Gln Leu Ala Leu Phe Ala Leu Gly Ile Val 
1               5                   10                  15      


Leu Ala Ala Cys Gln Ala Leu Glu Asn Ser Thr Ser Pro Leu Ser Asp 
            20                  25                  30          


Pro Pro Val Ala Ala Ala Val Val Ser His Phe Asn Asp Cys Pro Asp 
        35                  40                  45              


Ser His Thr Gln Phe Cys Phe His Gly Thr Cys Arg Phe Leu Val Gln 
    50                  55                  60                  


Glu Asp Lys Pro Ala Cys Val Cys His Ser Gly Tyr Val Gly Ala Arg 
65                  70                  75                  80  


Cys Glu His Ala Asp Leu Leu Ala Val Val Ala Ala Ser Gln Lys Lys 
                85                  90                  95      


Gln Ala Ile Thr Ala Leu Val Val Val Ser Ile Val Ala Leu Ala Val 
            100                 105                 110         


Leu Ile Ile Thr Cys Val Leu Ile His Cys Cys Gln Val Arg Lys His 
        115                 120                 125             


Cys Glu Trp Cys Arg Ala Leu Ile Cys Arg His Glu Lys Pro Ser Ala 
    130                 135                 140                 


Leu Leu Lys Gly Arg Thr Ala Cys Cys His Ser Glu Thr Val Val 
145                 150                 155                 


<210>  1171
<211>  879
<212>  PRT
<213>  Homo sapiens

<400>  1171

Met Ala Asp Gly Gly Gly Pro Lys Asp Ala Pro Ser Leu Arg Ser Ser 
1               5                   10                  15      


Pro Gly Pro Ala Pro Arg Val Pro Arg Ala Val Gly Pro Ser Gly Gly 
            20                  25                  30          


Gly Gly Glu Thr Pro Arg Thr Ala Ala Leu Ala Leu Arg Phe Asp Lys 
        35                  40                  45              


Pro Ile Lys Gln Ala Phe Tyr Asn Thr Gly Ala Val Leu Phe Val Cys 
    50                  55                  60                  


Leu Cys Cys Gly Ala Ala Val Leu Val Tyr Phe Ile Leu Glu Ala Phe 
65                  70                  75                  80  


Leu Arg Pro Leu Leu Trp Ala Val Leu Cys Gly Thr Phe Leu His Pro 
                85                  90                  95      


Phe Lys Ser Ser Leu Thr Arg Leu Gly Arg His Trp Leu Gln Arg Leu 
            100                 105                 110         


His Arg Ala His Thr Pro Ile Val Leu Ala Ala Leu Leu Leu Pro Leu 
        115                 120                 125             


Cys Phe Val Asp Tyr Gly Val Glu Ala Leu Gly Glu Gln Ala Leu Arg 
    130                 135                 140                 


Arg Arg Arg Leu Leu Leu Leu Leu Gly Ala Gly Gly Pro Leu Leu Tyr 
145                 150                 155                 160 


Gly Leu Tyr Cys Leu Gly Ser Tyr Leu Gly Val Gln Val Leu Leu Val 
                165                 170                 175     


His Ala Ala Thr Leu Ile Cys Arg Gly Leu Asp Tyr Phe Ser Ser Leu 
            180                 185                 190         


Trp Ile Trp Thr Leu Val Val Gly Tyr Val Leu Thr Val Ser Phe Lys 
        195                 200                 205             


Trp Asn Ala Ser Thr Glu Arg Tyr Leu Arg Ala Val Ser Ile Pro Val 
    210                 215                 220                 


Trp Ile Ile Leu Leu Phe His Leu Ala Ser Leu Ala Gly Ser Trp Arg 
225                 230                 235                 240 


Ile Pro Val Phe Leu Val Ile Val Phe Leu Met Ser Val Gly Thr Leu 
                245                 250                 255     


Tyr Glu Lys Gln Asn Gly Lys Glu Ser Ser Gly Ala Glu Leu Pro Gly 
            260                 265                 270         


Gln Val Ile Ser Met Ala Ala Ser Thr Leu Ala Asn Leu Ala Ile Ser 
        275                 280                 285             


Ile Thr Gly Tyr Glu Ser Ser Ser Glu Asp Gln Pro Ser Thr Gln Pro 
    290                 295                 300                 


Ala Glu Ala Val Asp Arg Gly Glu Ser Ala Pro Thr Leu Ser Thr Ser 
305                 310                 315                 320 


Pro Ser Pro Ser Ser Pro Ser Pro Thr Ser Pro Ser Pro Thr Leu Gly 
                325                 330                 335     


Arg Arg Arg Pro Glu Ile Gly Thr Phe Leu Arg Lys Lys Lys Thr Ser 
            340                 345                 350         


Asp Ile Tyr Phe Val Ser Leu Val Trp Ala Ile Val Val Met Gln Ile 
        355                 360                 365             


Trp Leu Asn Leu Trp Ile Val Gln Leu Leu Pro Val Pro Ile Ala Val 
    370                 375                 380                 


Trp Ile Leu Lys Lys Leu Val Ile His Phe Gly Val Val Asp Phe Leu 
385                 390                 395                 400 


Glu Lys Arg Tyr His Val Trp Trp Gly Ile Ile Glu Ser Phe Leu Lys 
                405                 410                 415     


Glu Arg Gln Gly Ala Leu Ala Pro Trp Pro Ile Val Gly Leu Gly Lys 
            420                 425                 430         


Phe Leu Leu Lys Val Asp Ser Lys Leu Trp His Trp Leu Asn Lys Lys 
        435                 440                 445             


Met Ile Ile Trp Leu Glu Lys Met Leu Asp Lys Ile Ile Ser Ile Phe 
    450                 455                 460                 


Ile Ile Phe Leu Leu Val Ile Gly Thr Leu Leu Leu Ala Leu Leu Leu 
465                 470                 475                 480 


Thr Ala Lys Val His Gln Glu Ser Val His Met Ile Glu Val Thr Ser 
                485                 490                 495     


Asn Leu Ile Asn Glu Thr Leu Ala Asn His Pro Glu Trp Ala Asn Trp 
            500                 505                 510         


Leu Pro Glu Ala Gln Val Val Gln Arg Ala Leu Asn Ser Ala Ala Asn 
        515                 520                 525             


Asn Val Tyr Gln Tyr Gly Arg Glu Trp Ile Thr His Lys Leu His Lys 
    530                 535                 540                 


Ile Leu Gly Asp Lys Val Asn Asn Thr Ala Val Ile Glu Lys Gln Val 
545                 550                 555                 560 


Leu Glu Leu Trp Asp Arg Leu Tyr His Ser Trp Phe Val Lys Asn Val 
                565                 570                 575     


Thr His Ser Gly Arg His Lys Gly Gln Lys Leu His Val Ser Arg Gln 
            580                 585                 590         


Asn Ser Trp Leu Gly Asp Ile Leu Asp Trp Gln Asp Ile Val Ser Phe 
        595                 600                 605             


Val His Glu Asn Ile Glu Thr Phe Leu Ser Ile Leu Glu Ser Leu Trp 
    610                 615                 620                 


Ile Val Met Ser Arg Asn Val Ser Leu Leu Phe Thr Thr Val Thr Thr 
625                 630                 635                 640 


Leu Leu Thr Ile Leu Phe Tyr Ser Gly Thr Ala Leu Leu Asn Phe Val 
                645                 650                 655     


Leu Ser Leu Ile Ile Phe Leu Thr Thr Leu Phe Tyr Leu Leu Ser Ser 
            660                 665                 670         


Ser Asp Glu Tyr Tyr Lys Pro Val Lys Trp Val Ile Ser Leu Thr Pro 
        675                 680                 685             


Leu Ser Gln Pro Gly Pro Ser Ser Asn Ile Ile Gly Gln Ser Val Glu 
    690                 695                 700                 


Glu Ala Ile Arg Gly Val Phe Asp Ala Ser Leu Lys Met Ala Gly Phe 
705                 710                 715                 720 


Tyr Gly Leu Tyr Thr Trp Leu Thr His Thr Met Phe Gly Ile Asn Ile 
                725                 730                 735     


Val Phe Ile Pro Ser Ala Leu Ala Ala Ile Leu Gly Ala Val Pro Phe 
            740                 745                 750         


Leu Gly Thr Tyr Trp Ala Ala Val Pro Ala Val Leu Asp Leu Trp Leu 
        755                 760                 765             


Thr Gln Gly Leu Gly Cys Lys Ala Ile Leu Leu Leu Ile Phe His Leu 
    770                 775                 780                 


Leu Pro Thr Tyr Phe Val Asp Thr Ala Ile Tyr Ser Asp Ile Ser Gly 
785                 790                 795                 800 


Gly Gly His Pro Tyr Leu Thr Gly Leu Ala Val Ala Gly Gly Ala Tyr 
                805                 810                 815     


Tyr Leu Gly Leu Glu Gly Ala Ile Ile Gly Pro Ile Leu Leu Cys Ile 
            820                 825                 830         


Leu Val Val Ala Ser Asn Ile Tyr Ser Ala Met Leu Val Ser Pro Thr 
        835                 840                 845             


Asn Ser Val Pro Thr Pro Asn Gln Thr Pro Trp Pro Ala Gln Pro Gln 
    850                 855                 860                 


Arg Thr Phe Arg Asp Ile Ser Glu Asp Leu Lys Ser Ser Val Gly 
865                 870                 875                 


<210>  1172
<211>  512
<212>  PRT
<213>  Homo sapiens

<400>  1172

Met Val Pro Ser Phe Leu Ser Leu Ser Phe Ser Ser Leu Gly Leu Trp 
1               5                   10                  15      


Ala Ser Gly Leu Ile Leu Val Leu Gly Phe Leu Lys Leu Ile His Leu 
            20                  25                  30          


Leu Leu Arg Arg Gln Thr Leu Ala Lys Ala Met Asp Lys Phe Pro Gly 
        35                  40                  45              


Pro Pro Thr His Trp Leu Phe Gly His Ala Leu Glu Ile Gln Glu Thr 
    50                  55                  60                  


Gly Ser Leu Asp Lys Val Val Ser Trp Ala His Gln Phe Pro Tyr Ala 
65                  70                  75                  80  


His Pro Leu Trp Phe Gly Gln Phe Ile Gly Phe Leu Asn Ile Tyr Glu 
                85                  90                  95      


Pro Asp Tyr Ala Lys Ala Val Tyr Ser Arg Gly Asp Pro Lys Ala Pro 
            100                 105                 110         


Asp Val Tyr Asp Phe Phe Leu Gln Trp Ile Gly Arg Gly Leu Leu Val 
        115                 120                 125             


Leu Glu Gly Pro Lys Trp Leu Gln His Arg Lys Leu Leu Thr Pro Gly 
    130                 135                 140                 


Phe His Tyr Asp Val Leu Lys Pro Tyr Val Ala Val Phe Thr Glu Ser 
145                 150                 155                 160 


Thr Arg Ile Met Leu Asp Lys Trp Glu Glu Lys Ala Arg Glu Gly Lys 
                165                 170                 175     


Ser Phe Asp Ile Phe Cys Asp Val Gly His Met Ala Leu Asn Thr Leu 
            180                 185                 190         


Met Lys Cys Thr Phe Gly Arg Gly Asp Thr Gly Leu Gly His Ser Arg 
        195                 200                 205             


Asp Ser Ser Tyr Tyr Leu Ala Val Ser Asp Leu Thr Leu Leu Met Gln 
    210                 215                 220                 


Gln Arg Leu Val Ser Phe Gln Tyr His Asn Asp Phe Ile Tyr Trp Leu 
225                 230                 235                 240 


Thr Pro His Gly Arg Arg Phe Leu Arg Ala Cys Gln Val Ala His Asp 
                245                 250                 255     


His Thr Asp Gln Val Ile Arg Glu Arg Lys Ala Ala Leu Gln Asp Glu 
            260                 265                 270         


Lys Val Arg Lys Lys Ile Gln Asn Arg Arg His Leu Asp Phe Leu Asp 
        275                 280                 285             


Ile Leu Leu Gly Ala Arg Asp Glu Asp Asp Ile Lys Leu Ser Asp Ala 
    290                 295                 300                 


Asp Leu Arg Ala Glu Val Asp Thr Phe Met Phe Glu Gly His Asp Thr 
305                 310                 315                 320 


Thr Thr Ser Gly Ile Ser Trp Phe Leu Tyr Cys Met Ala Leu Tyr Pro 
                325                 330                 335     


Glu His Gln His Arg Cys Arg Glu Glu Val Arg Glu Ile Leu Gly Asp 
            340                 345                 350         


Gln Asp Phe Phe Gln Trp Asp Asp Leu Gly Lys Met Thr Tyr Leu Thr 
        355                 360                 365             


Met Cys Ile Lys Glu Ser Phe Arg Leu Tyr Pro Pro Val Pro Gln Val 
    370                 375                 380                 


Tyr Arg Gln Leu Ser Lys Pro Val Thr Phe Val Asp Gly Arg Ser Leu 
385                 390                 395                 400 


Pro Ala Gly Ser Leu Ile Ser Met His Ile Tyr Ala Leu His Arg Asn 
                405                 410                 415     


Ser Ala Val Trp Pro Asp Pro Glu Val Phe Asp Ser Leu Arg Phe Ser 
            420                 425                 430         


Thr Glu Asn Ala Ser Lys Arg His Pro Phe Ala Phe Met Pro Phe Ser 
        435                 440                 445             


Ala Gly Pro Arg Asn Cys Ile Gly Gln Gln Phe Ala Met Ser Glu Met 
    450                 455                 460                 


Lys Val Val Thr Ala Met Cys Leu Leu Arg Phe Glu Phe Ser Leu Asp 
465                 470                 475                 480 


Pro Ser Arg Leu Pro Ile Lys Met Pro Gln Leu Val Leu Arg Ser Lys 
                485                 490                 495     


Asn Gly Phe His Leu His Leu Lys Pro Leu Gly Pro Gly Ser Gly Lys 
            500                 505                 510         


<210>  1173
<211>  587
<212>  PRT
<213>  Homo sapiens

<400>  1173

Met Ala Arg Gly Tyr Gly Ala Thr Val Ser Leu Val Leu Leu Gly Leu 
1               5                   10                  15      


Gly Leu Ala Leu Ala Val Ile Val Leu Ala Val Val Leu Ser Arg His 
            20                  25                  30          


Gln Ala Pro Cys Gly Pro Gln Ala Phe Ala His Ala Ala Val Ala Ala 
        35                  40                  45              


Asp Ser Lys Val Cys Ser Asp Ile Gly Arg Ala Ile Leu Gln Gln Gln 
    50                  55                  60                  


Gly Ser Pro Val Asp Ala Thr Ile Ala Ala Leu Val Cys Thr Ser Val 
65                  70                  75                  80  


Val Asn Pro Gln Ser Met Gly Leu Gly Gly Gly Val Ile Phe Thr Ile 
                85                  90                  95      


Tyr Asn Val Thr Thr Gly Lys Val Glu Val Ile Asn Ala Arg Glu Thr 
            100                 105                 110         


Val Pro Ala Ser His Ala Pro Ser Leu Leu Asp Gln Cys Ala Gln Ala 
        115                 120                 125             


Leu Pro Leu Gly Thr Gly Ala Gln Trp Ile Gly Val Pro Gly Glu Leu 
    130                 135                 140                 


Arg Gly Tyr Ala Glu Ala His Arg Arg His Gly Arg Leu Pro Trp Ala 
145                 150                 155                 160 


Gln Leu Phe Gln Pro Thr Ile Ala Leu Leu Arg Gly Gly His Val Val 
                165                 170                 175     


Ala Pro Val Leu Ser Arg Phe Leu His Asn Ser Ile Leu Arg Pro Ser 
            180                 185                 190         


Leu Gln Ala Ser Thr Leu Arg Gln Leu Phe Phe Asn Gly Thr Glu Pro 
        195                 200                 205             


Leu Arg Pro Gln Asp Pro Leu Pro Trp Pro Ala Leu Ala Thr Thr Leu 
    210                 215                 220                 


Glu Thr Val Ala Thr Glu Gly Val Glu Val Phe Tyr Thr Gly Arg Leu 
225                 230                 235                 240 


Gly Gln Met Leu Val Glu Asp Ile Ala Lys Glu Gly Ser Gln Leu Thr 
                245                 250                 255     


Leu Gln Asp Leu Ala Lys Phe Gln Pro Glu Val Val Asp Ala Leu Glu 
            260                 265                 270         


Val Pro Leu Gly Asp Tyr Thr Leu Tyr Ser Pro Pro Pro Pro Ala Gly 
        275                 280                 285             


Gly Ala Ile Leu Ser Phe Ile Leu Asn Val Leu Arg Gly Phe Asn Phe 
    290                 295                 300                 


Ser Thr Glu Ser Met Ala Arg Pro Glu Gly Arg Val Asn Val Tyr His 
305                 310                 315                 320 


His Leu Val Glu Thr Leu Lys Phe Ala Lys Gly Gln Arg Trp Arg Leu 
                325                 330                 335     


Gly Asp Pro Arg Ser His Pro Lys Leu Gln Asn Ala Ser Arg Asp Leu 
            340                 345                 350         


Leu Gly Glu Thr Leu Ala Gln Leu Ile Arg Gln Gln Ile Asp Gly Arg 
        355                 360                 365             


Gly Asp His Gln Leu Ser His Tyr Ser Leu Ala Glu Ala Trp Gly His 
    370                 375                 380                 


Gly Thr Gly Thr Ser His Val Ser Val Leu Gly Glu Asp Gly Ser Ala 
385                 390                 395                 400 


Val Ala Ala Thr Ser Thr Ile Asn Thr Pro Phe Gly Ala Met Val Tyr 
                405                 410                 415     


Ser Pro Arg Thr Gly Ile Ile Leu Asn Asn Glu Leu Leu Asp Leu Cys 
            420                 425                 430         


Glu Arg Cys Pro Arg Gly Ser Gly Thr Thr Pro Ser Pro Ala Val Ser 
        435                 440                 445             


Gly Asp Arg Val Gly Gly Ala Pro Gly Arg Cys Trp Pro Pro Val Pro 
    450                 455                 460                 


Gly Glu Arg Ser Pro Ser Ser Met Val Pro Ser Ile Leu Ile Asn Lys 
465                 470                 475                 480 


Ala Gln Gly Ser Lys Leu Val Ile Gly Gly Ala Gly Gly Glu Leu Ile 
                485                 490                 495     


Ile Ser Ala Val Ala Gln Ala Ile Met Ser Lys Leu Trp Leu Gly Phe 
            500                 505                 510         


Asp Leu Arg Ala Ala Ile Ala Ala Pro Ile Leu His Val Asn Ser Lys 
        515                 520                 525             


Gly Cys Val Glu Tyr Glu Pro Asn Phe Ser Gln Glu Val Gln Arg Gly 
    530                 535                 540                 


Leu Gln Asp Arg Gly Gln Asn Gln Thr Gln Arg Pro Phe Phe Leu Asn 
545                 550                 555                 560 


Val Val Gln Ala Val Ser Gln Glu Gly Ala Cys Val Tyr Ala Val Ser 
                565                 570                 575     


Asp Leu Arg Lys Ser Gly Glu Ala Ala Gly Tyr 
            580                 585         


<210>  1174
<211>  554
<212>  PRT
<213>  Homo sapiens

<400>  1174

Met Ala Arg Gly Tyr Gly Ala Thr Val Ser Leu Val Leu Leu Gly Leu 
1               5                   10                  15      


Gly Leu Ala Leu Ala Val Ile Val Leu Ala Val Val Leu Ser Arg His 
            20                  25                  30          


Gln Ala Pro Cys Gly Pro Gln Ala Phe Ala His Ala Ala Val Ala Ala 
        35                  40                  45              


Asp Ser Lys Val Cys Ser Asp Ile Gly Arg Ala Ile Leu Gln Gln Gln 
    50                  55                  60                  


Gly Ser Pro Val Asp Ala Thr Ile Ala Ala Leu Val Cys Thr Ser Val 
65                  70                  75                  80  


Val Asn Pro Gln Ser Met Gly Leu Gly Gly Gly Val Ile Phe Thr Ile 
                85                  90                  95      


Tyr Asn Val Thr Thr Gly Ala Gln Trp Ile Gly Val Pro Gly Glu Leu 
            100                 105                 110         


Arg Gly Tyr Ala Glu Ala His Arg Arg His Gly Arg Leu Pro Trp Ala 
        115                 120                 125             


Gln Leu Phe Gln Pro Thr Ile Ala Leu Leu Arg Gly Gly His Val Val 
    130                 135                 140                 


Ala Pro Val Leu Ser Arg Phe Leu His Asn Ser Ile Leu Arg Pro Ser 
145                 150                 155                 160 


Leu Gln Ala Ser Thr Leu Arg Gln Leu Phe Phe Asn Gly Thr Glu Pro 
                165                 170                 175     


Leu Arg Pro Gln Asp Pro Leu Pro Trp Pro Ala Leu Ala Thr Thr Leu 
            180                 185                 190         


Glu Thr Val Ala Thr Glu Gly Val Glu Val Phe Tyr Thr Gly Arg Leu 
        195                 200                 205             


Gly Gln Met Leu Val Glu Asp Ile Ala Lys Glu Gly Ser Gln Leu Thr 
    210                 215                 220                 


Leu Gln Asp Leu Ala Lys Phe Gln Pro Glu Val Val Asp Ala Leu Glu 
225                 230                 235                 240 


Val Pro Leu Gly Asp Tyr Thr Leu Tyr Ser Pro Pro Pro Pro Ala Gly 
                245                 250                 255     


Gly Ala Ile Leu Ser Phe Ile Leu Asn Val Leu Arg Gly Phe Asn Phe 
            260                 265                 270         


Ser Thr Glu Ser Met Ala Arg Pro Glu Gly Arg Val Asn Val Tyr His 
        275                 280                 285             


His Leu Val Glu Thr Leu Lys Phe Ala Lys Gly Gln Arg Trp Arg Leu 
    290                 295                 300                 


Gly Asp Pro Arg Ser His Pro Lys Leu Gln Asn Ala Ser Arg Asp Leu 
305                 310                 315                 320 


Leu Gly Glu Thr Leu Ala Gln Leu Ile Arg Gln Gln Ile Asp Gly Arg 
                325                 330                 335     


Gly Asp His Gln Leu Ser His Tyr Ser Leu Ala Glu Ala Trp Gly His 
            340                 345                 350         


Gly Thr Gly Thr Ser His Val Ser Val Leu Gly Glu Asp Gly Ser Ala 
        355                 360                 365             


Val Ala Ala Thr Ser Thr Ile Asn Thr Pro Phe Gly Ala Met Val Tyr 
    370                 375                 380                 


Ser Pro Arg Thr Gly Ile Ile Leu Asn Asn Glu Leu Leu Asp Leu Cys 
385                 390                 395                 400 


Glu Arg Cys Pro Arg Gly Ser Gly Thr Thr Pro Ser Pro Val Ser Gly 
                405                 410                 415     


Asp Arg Val Gly Gly Ala Pro Gly Arg Cys Trp Pro Pro Val Pro Gly 
            420                 425                 430         


Glu Arg Ser Pro Ser Ser Met Val Pro Ser Ile Leu Ile Asn Lys Ala 
        435                 440                 445             


Gln Gly Ser Lys Leu Val Ile Gly Gly Ala Gly Gly Glu Leu Ile Ile 
    450                 455                 460                 


Ser Ala Val Ala Gln Ala Ile Met Ser Lys Leu Trp Leu Gly Phe Asp 
465                 470                 475                 480 


Leu Arg Ala Ala Ile Ala Ala Pro Ile Leu His Val Asn Ser Lys Gly 
                485                 490                 495     


Cys Val Glu Tyr Glu Pro Asn Phe Ser Gln Glu Val Gln Arg Gly Leu 
            500                 505                 510         


Gln Asp Arg Gly Gln Asn Gln Thr Gln Arg Pro Phe Phe Leu Asn Val 
        515                 520                 525             


Val Gln Ala Val Ser Gln Glu Gly Ala Cys Val Tyr Ala Val Ser Asp 
    530                 535                 540                 


Leu Arg Lys Ser Gly Glu Ala Ala Gly Tyr 
545                 550                 


<210>  1175
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  1175

Met Ser Ser Phe Gly Tyr Arg Thr Leu Thr Val Ala Leu Phe Thr Leu 
1               5                   10                  15      


Ile Cys Cys Pro Gly Ser Asp Glu Lys Val Phe Glu Val His Val Arg 
            20                  25                  30          


Pro Lys Lys Leu Ala Val Glu Pro Lys Gly Ser Leu Glu Val Asn Cys 
        35                  40                  45              


Ser Thr Thr Cys Asn Gln Pro Glu Val Gly Gly Leu Glu Thr Ser Leu 
    50                  55                  60                  


Asp Lys Ile Leu Leu Asp Glu Gln Ala Gln Trp Lys His Tyr Leu Val 
65                  70                  75                  80  


Ser Asn Ile Ser His Asp Thr Val Leu Gln Cys His Phe Thr Cys Ser 
                85                  90                  95      


Gly Lys Gln Glu Ser Met Asn Ser Asn Val Ser Val Tyr Gln Pro Pro 
            100                 105                 110         


Arg Gln Val Ile Leu Thr Leu Gln Pro Thr Leu Val Ala Val Gly Lys 
        115                 120                 125             


Ser Phe Thr Ile Glu Cys Arg Val Pro Thr Val Glu Pro Leu Asp Ser 
    130                 135                 140                 


Leu Thr Leu Phe Leu Phe Arg Gly Asn Glu Thr Leu His Tyr Glu Thr 
145                 150                 155                 160 


Phe Gly Lys Ala Ala Pro Ala Pro Gln Glu Ala Thr Ala Thr Phe Asn 
                165                 170                 175     


Ser Thr Ala Asp Arg Glu Asp Gly His Arg Asn Phe Ser Cys Leu Ala 
            180                 185                 190         


Val Leu Asp Leu Met Ser Arg Gly Gly Asn Ile Phe His Lys His Ser 
        195                 200                 205             


Ala Pro Lys Met Leu Glu Ile Tyr Glu Pro Val Ser Asp Ser Gln Met 
    210                 215                 220                 


Val Ile Ile Val Thr Val Val Ser Val Leu Leu Ser Leu Phe Val Thr 
225                 230                 235                 240 


Ser Val Leu Leu Cys Phe Ile Phe Gly Gln His Leu Arg Gln Gln Arg 
                245                 250                 255     


Met Gly Thr Tyr Gly Val Arg Ala Ala Trp Arg Arg Leu Pro Gln Ala 
            260                 265                 270         


Phe Arg Pro 
        275 


<210>  1176
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  1176

Met Ser Ser Phe Gly Tyr Arg Thr Leu Thr Val Ala Leu Phe Thr Leu 
1               5                   10                  15      


Ile Cys Cys Pro Gly Ser Asp Glu Lys Val Phe Glu Val His Val Arg 
            20                  25                  30          


Pro Lys Lys Leu Ala Val Glu Pro Lys Gly Ser Leu Glu Val Asn Cys 
        35                  40                  45              


Ser Thr Thr Cys Asn Gln Pro Glu Val Gly Gly Leu Glu Thr Ser Leu 
    50                  55                  60                  


Asp Lys Ile Leu Leu Asp Glu Gln Ala Gln Trp Lys His Tyr Leu Val 
65                  70                  75                  80  


Ser Asn Ile Ser His Asp Thr Val Leu Gln Cys His Phe Thr Cys Ser 
                85                  90                  95      


Gly Lys Gln Glu Ser Met Asn Ser Asn Val Ser Val Tyr Gln Pro Pro 
            100                 105                 110         


Arg Gln Val Ile Leu Thr Leu Gln Pro Thr Leu Val Ala Val Gly Lys 
        115                 120                 125             


Ser Phe Thr Ile Glu Cys Arg Val Pro Thr Val Glu Pro Leu Asp Ser 
    130                 135                 140                 


Leu Thr Leu Phe Leu Phe Arg Gly Asn Glu Thr Leu His Tyr Glu Thr 
145                 150                 155                 160 


Phe Gly Lys Ala Ala Pro Ala Pro Gln Glu Ala Thr Ala Thr Phe Asn 
                165                 170                 175     


Ser Thr Ala Asp Arg Glu Asp Gly His Arg Asn Phe Ser Cys Leu Ala 
            180                 185                 190         


Val Leu Asp Leu Met Ser Arg Gly Gly Asn Ile Phe His Lys His Ser 
        195                 200                 205             


Ala Pro Lys Met Leu Glu Ile Tyr Glu Pro Val Ser Asp Ser Gln Met 
    210                 215                 220                 


Val Ile Ile Val Thr Val Val Ser Val Leu Leu Ser Leu Phe Val Thr 
225                 230                 235                 240 


Ser Val Leu Leu Cys Phe Ile Phe Gly Gln His Leu Arg Gln Gln Arg 
                245                 250                 255     


Met Gly Thr Tyr Gly Val Arg Ala Ala Trp Arg Arg Leu Pro Gln Ala 
            260                 265                 270         


Phe Arg Pro 
        275 


<210>  1177
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  1177

Met Ser Ser Phe Gly Tyr Arg Thr Leu Thr Val Ala Leu Phe Thr Leu 
1               5                   10                  15      


Ile Cys Cys Pro Gly Ser Asp Glu Lys Val Phe Glu Val His Val Arg 
            20                  25                  30          


Pro Lys Lys Leu Ala Val Glu Pro Lys Gly Ser Leu Glu Val Asn Cys 
        35                  40                  45              


Ser Thr Thr Cys Asn Gln Pro Glu Val Gly Gly Leu Glu Thr Ser Leu 
    50                  55                  60                  


Asp Lys Ile Leu Leu Asp Glu Gln Ala Gln Trp Lys His Tyr Leu Val 
65                  70                  75                  80  


Ser Asn Ile Ser His Asp Thr Val Leu Gln Cys His Phe Thr Cys Ser 
                85                  90                  95      


Gly Lys Gln Glu Ser Met Asn Ser Asn Val Ser Val Tyr Gln Pro Pro 
            100                 105                 110         


Arg Gln Val Ile Leu Thr Leu Gln Pro Thr Leu Val Ala Val Gly Lys 
        115                 120                 125             


Ser Phe Thr Ile Glu Cys Arg Val Pro Thr Val Glu Pro Leu Asp Ser 
    130                 135                 140                 


Leu Thr Leu Phe Leu Phe Arg Gly Asn Glu Thr Leu His Tyr Glu Thr 
145                 150                 155                 160 


Phe Gly Lys Ala Ala Pro Ala Pro Gln Glu Ala Thr Ala Thr Phe Asn 
                165                 170                 175     


Ser Thr Ala Asp Arg Glu Asp Gly His Arg Asn Phe Ser Cys Leu Ala 
            180                 185                 190         


Val Leu Asp Leu Met Ser Arg Gly Gly Asn Ile Phe His Lys His Ser 
        195                 200                 205             


Ala Pro Lys Met Leu Glu Ile Tyr Glu Pro Val Ser Asp Ser Gln Met 
    210                 215                 220                 


Val Ile Ile Val Thr Val Val Ser Val Leu Leu Ser Leu Phe Val Thr 
225                 230                 235                 240 


Ser Val Leu Leu Cys Phe Ile Phe Gly Gln His Leu Arg Gln Gln Arg 
                245                 250                 255     


Met Gly Thr Tyr Gly Val Arg Ala Ala Trp Arg Arg Leu Pro Gln Ala 
            260                 265                 270         


Phe Arg Pro 
        275 


<210>  1178
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  1178

Met Ser Ser Phe Gly Tyr Arg Thr Leu Thr Val Ala Leu Phe Thr Leu 
1               5                   10                  15      


Ile Cys Cys Pro Gly Ser Asp Glu Lys Val Phe Glu Val His Val Arg 
            20                  25                  30          


Pro Lys Lys Leu Ala Val Glu Pro Lys Gly Ser Leu Glu Val Asn Cys 
        35                  40                  45              


Ser Thr Thr Cys Asn Gln Pro Glu Val Gly Gly Leu Glu Thr Ser Leu 
    50                  55                  60                  


Asp Lys Ile Leu Leu Asp Glu Gln Ala Gln Trp Lys His Tyr Leu Val 
65                  70                  75                  80  


Ser Asn Ile Ser His Asp Thr Val Leu Gln Cys His Phe Thr Cys Ser 
                85                  90                  95      


Gly Lys Gln Glu Ser Met Asn Ser Asn Val Ser Val Tyr Gln Pro Pro 
            100                 105                 110         


Arg Gln Val Ile Leu Thr Leu Gln Pro Thr Leu Val Ala Val Gly Lys 
        115                 120                 125             


Ser Phe Thr Ile Glu Cys Arg Val Pro Thr Val Glu Pro Leu Asp Ser 
    130                 135                 140                 


Leu Thr Leu Phe Leu Phe Arg Gly Asn Glu Thr Leu His Tyr Glu Thr 
145                 150                 155                 160 


Phe Gly Lys Ala Ala Pro Ala Pro Gln Glu Ala Thr Ala Thr Phe Asn 
                165                 170                 175     


Ser Thr Ala Asp Arg Glu Asp Gly His Arg Asn Phe Ser Cys Leu Ala 
            180                 185                 190         


Val Leu Asp Leu Met Ser Arg Gly Gly Asn Ile Phe His Lys His Ser 
        195                 200                 205             


Ala Pro Lys Met Leu Glu Ile Tyr Glu Pro Val Ser Asp Ser Gln Met 
    210                 215                 220                 


Val Ile Ile Val Thr Val Val Ser Val Leu Leu Ser Leu Phe Val Thr 
225                 230                 235                 240 


Ser Val Leu Leu Cys Phe Ile Phe Gly Gln His Leu Arg Gln Gln Arg 
                245                 250                 255     


Met Gly Thr Tyr Gly Val Arg Ala Ala Trp Arg Arg Leu Pro Gln Ala 
            260                 265                 270         


Phe Arg Pro 
        275 


<210>  1179
<211>  2710
<212>  PRT
<213>  Homo sapiens

<400>  1179

Met Ser Asp Lys Met Ser Ser Phe Leu His Ile Gly Asp Ile Cys Ser 
1               5                   10                  15      


Leu Tyr Ala Glu Gly Ser Thr Asn Gly Phe Ile Ser Thr Leu Gly Leu 
            20                  25                  30          


Val Asp Asp Arg Cys Val Val Gln Pro Glu Thr Gly Asp Leu Asn Asn 
        35                  40                  45              


Pro Pro Lys Lys Phe Arg Asp Cys Leu Phe Lys Leu Cys Pro Met Asn 
    50                  55                  60                  


Arg Tyr Ser Ala Gln Lys Gln Phe Trp Lys Ala Ala Lys Pro Gly Ala 
65                  70                  75                  80  


Asn Ser Thr Thr Asp Ala Val Leu Leu Asn Lys Leu His His Ala Ala 
                85                  90                  95      


Asp Leu Glu Lys Lys Gln Asn Glu Thr Glu Asn Arg Lys Leu Leu Gly 
            100                 105                 110         


Thr Val Ile Gln Tyr Gly Asn Val Ile Gln Leu Leu His Leu Lys Ser 
        115                 120                 125             


Asn Lys Tyr Leu Thr Val Asn Lys Arg Leu Pro Ala Leu Leu Glu Lys 
    130                 135                 140                 


Asn Ala Met Arg Val Thr Leu Asp Glu Ala Gly Asn Glu Gly Ser Trp 
145                 150                 155                 160 


Phe Tyr Ile Gln Pro Phe Tyr Lys Leu Arg Ser Ile Gly Asp Ser Val 
                165                 170                 175     


Val Ile Gly Asp Lys Val Val Leu Asn Pro Val Asn Ala Gly Gln Pro 
            180                 185                 190         


Leu His Ala Ser Ser His Gln Leu Val Asp Asn Pro Gly Cys Asn Glu 
        195                 200                 205             


Val Asn Ser Val Asn Cys Asn Thr Ser Trp Lys Ile Val Leu Phe Met 
    210                 215                 220                 


Lys Trp Ser Asp Asn Lys Asp Asp Ile Leu Lys Gly Gly Asp Val Val 
225                 230                 235                 240 


Arg Leu Phe His Ala Glu Gln Glu Lys Phe Leu Thr Cys Asp Glu His 
                245                 250                 255     


Arg Lys Lys Gln His Val Phe Leu Arg Thr Thr Gly Arg Gln Ser Ala 
            260                 265                 270         


Thr Ser Ala Thr Ser Ser Lys Ala Leu Trp Glu Val Glu Val Val Gln 
        275                 280                 285             


His Asp Pro Cys Arg Gly Gly Ala Gly Tyr Trp Asn Ser Leu Phe Arg 
    290                 295                 300                 


Phe Lys His Leu Ala Thr Gly His Tyr Leu Ala Ala Glu Val Asp Pro 
305                 310                 315                 320 


Asp Phe Glu Glu Glu Cys Leu Glu Phe Gln Pro Ser Val Asp Pro Asp 
                325                 330                 335     


Gln Asp Ala Ser Arg Ser Arg Leu Arg Asn Ala Gln Glu Lys Met Val 
            340                 345                 350         


Tyr Ser Leu Val Ser Val Pro Glu Gly Asn Asp Ile Ser Ser Ile Phe 
        355                 360                 365             


Glu Leu Asp Pro Thr Thr Leu Arg Gly Gly Asp Ser Leu Val Pro Arg 
    370                 375                 380                 


Asn Ser Tyr Val Arg Leu Arg His Leu Cys Thr Asn Thr Trp Val His 
385                 390                 395                 400 


Ser Thr Asn Ile Pro Ile Asp Lys Glu Glu Glu Lys Pro Val Met Leu 
                405                 410                 415     


Lys Ile Gly Thr Ser Pro Val Lys Glu Asp Lys Glu Ala Phe Ala Ile 
            420                 425                 430         


Val Pro Val Ser Pro Ala Glu Val Arg Asp Leu Asp Phe Ala Asn Asp 
        435                 440                 445             


Ala Ser Lys Val Leu Gly Ser Ile Ala Gly Lys Leu Glu Lys Gly Thr 
    450                 455                 460                 


Ile Thr Gln Asn Glu Arg Arg Ser Val Thr Lys Leu Leu Glu Asp Leu 
465                 470                 475                 480 


Val Tyr Phe Val Thr Gly Gly Thr Asn Ser Gly Gln Asp Val Leu Glu 
                485                 490                 495     


Val Val Phe Ser Lys Pro Asn Arg Glu Arg Gln Lys Leu Met Arg Glu 
            500                 505                 510         


Gln Asn Ile Leu Lys Gln Ile Phe Lys Leu Leu Gln Ala Pro Phe Thr 
        515                 520                 525             


Asp Cys Gly Asp Gly Pro Met Leu Arg Leu Glu Glu Leu Gly Asp Gln 
    530                 535                 540                 


Arg His Ala Pro Phe Arg His Ile Cys Arg Leu Cys Tyr Arg Val Leu 
545                 550                 555                 560 


Arg His Ser Gln Gln Asp Tyr Arg Lys Asn Gln Glu Tyr Ile Ala Lys 
                565                 570                 575     


Gln Phe Gly Phe Met Gln Lys Gln Ile Gly Tyr Asp Val Leu Ala Glu 
            580                 585                 590         


Asp Thr Ile Thr Ala Leu Leu His Asn Asn Arg Lys Leu Leu Glu Lys 
        595                 600                 605             


His Ile Thr Ala Ala Glu Ile Asp Thr Phe Val Ser Leu Val Arg Lys 
    610                 615                 620                 


Asn Arg Glu Pro Arg Phe Leu Asp Tyr Leu Ser Asp Leu Cys Val Ser 
625                 630                 635                 640 


Met Asn Lys Ser Ile Pro Val Thr Gln Glu Leu Ile Cys Lys Ala Val 
                645                 650                 655     


Leu Asn Pro Thr Asn Ala Asp Ile Leu Ile Glu Thr Lys Leu Val Leu 
            660                 665                 670         


Ser Arg Phe Glu Phe Glu Gly Val Ser Ser Thr Gly Glu Asn Ala Leu 
        675                 680                 685             


Glu Ala Gly Glu Asp Glu Glu Glu Val Trp Leu Phe Trp Arg Asp Ser 
    690                 695                 700                 


Asn Lys Glu Ile Arg Ser Lys Ser Val Arg Glu Leu Ala Gln Asp Ala 
705                 710                 715                 720 


Lys Glu Gly Gln Lys Glu Asp Arg Asp Val Leu Ser Tyr Tyr Arg Tyr 
                725                 730                 735     


Gln Leu Asn Leu Phe Ala Arg Met Cys Leu Asp Arg Gln Tyr Leu Ala 
            740                 745                 750         


Ile Asn Glu Ile Ser Gly Gln Leu Asp Val Asp Leu Ile Leu Arg Cys 
        755                 760                 765             


Met Ser Asp Glu Asn Leu Pro Tyr Asp Leu Arg Ala Ser Phe Cys Arg 
    770                 775                 780                 


Leu Met Leu His Met His Val Asp Arg Asp Pro Gln Glu Gln Val Thr 
785                 790                 795                 800 


Pro Val Lys Tyr Ala Arg Leu Trp Ser Glu Ile Pro Ser Glu Ile Ala 
                805                 810                 815     


Ile Asp Asp Tyr Asp Ser Ser Gly Ala Ser Lys Asp Glu Ile Lys Glu 
            820                 825                 830         


Arg Phe Ala Gln Thr Met Glu Phe Val Glu Glu Tyr Leu Arg Asp Val 
        835                 840                 845             


Val Cys Gln Arg Phe Pro Phe Ser Asp Lys Glu Lys Asn Lys Leu Thr 
    850                 855                 860                 


Phe Glu Val Val Asn Leu Ala Arg Asn Leu Ile Tyr Phe Gly Phe Tyr 
865                 870                 875                 880 


Asn Phe Ser Asp Leu Leu Arg Leu Thr Lys Ile Leu Leu Ala Ile Leu 
                885                 890                 895     


Asp Cys Val His Val Thr Thr Ile Phe Pro Ile Ser Lys Met Ala Lys 
            900                 905                 910         


Gly Glu Glu Asn Lys Gly Ser Asn Val Met Arg Ser Ile His Gly Val 
        915                 920                 925             


Gly Glu Leu Met Thr Gln Val Val Leu Arg Gly Gly Gly Phe Leu Pro 
    930                 935                 940                 


Met Thr Pro Met Ala Ala Ala Pro Glu Gly Asn Val Lys Gln Ala Glu 
945                 950                 955                 960 


Pro Glu Lys Glu Asp Ile Met Val Met Asp Thr Lys Leu Lys Ile Ile 
                965                 970                 975     


Glu Ile Leu Gln Phe Ile Leu Asn Val Arg Leu Asp Tyr Arg Ile Ser 
            980                 985                 990         


Cys Leu Leu Cys Ile Phe Lys Arg  Glu Phe Asp Glu Ser  Asn Ser Gln 
        995                 1000                 1005             


Thr Ser  Glu Thr Ser Ser Gly  Asn Ser Ser Gln Glu  Gly Pro Ser 
    1010                 1015                 1020             


Asn Val  Pro Gly Ala Leu Asp  Phe Glu His Ile Glu  Glu Gln Ala 
    1025                 1030                 1035             


Glu Gly  Ile Phe Gly Gly Ser  Glu Glu Asn Thr Pro  Leu Asp Leu 
    1040                 1045                 1050             


Asp Asp  His Gly Gly Arg Thr  Phe Leu Arg Val Leu  Leu His Leu 
    1055                 1060                 1065             


Thr Met  His Asp Tyr Pro Pro  Leu Val Ser Gly Ala  Leu Gln Leu 
    1070                 1075                 1080             


Leu Phe  Arg His Phe Ser Gln  Arg Gln Glu Val Leu  Gln Ala Phe 
    1085                 1090                 1095             


Lys Gln  Val Gln Leu Leu Val  Thr Ser Gln Asp Val  Asp Asn Tyr 
    1100                 1105                 1110             


Lys Gln  Ile Lys Gln Asp Leu  Asp Gln Leu Arg Ser  Ile Val Glu 
    1115                 1120                 1125             


Lys Ser  Glu Leu Trp Val Tyr  Lys Gly Gln Gly Pro  Asp Glu Thr 
    1130                 1135                 1140             


Met Asp  Gly Ala Ser Gly Glu  Asn Glu His Lys Lys  Thr Glu Glu 
    1145                 1150                 1155             


Gly Asn  Asn Lys Pro Gln Lys  His Glu Ser Thr Ser  Ser Tyr Asn 
    1160                 1165                 1170             


Tyr Arg  Val Val Lys Glu Ile  Leu Ile Arg Leu Ser  Lys Leu Cys 
    1175                 1180                 1185             


Val Gln  Glu Ser Ala Ser Val  Arg Lys Ser Arg Lys  Gln Gln Gln 
    1190                 1195                 1200             


Arg Leu  Leu Arg Asn Met Gly  Ala His Ala Val Val  Leu Glu Leu 
    1205                 1210                 1215             


Leu Gln  Ile Pro Tyr Glu Lys  Ala Glu Asp Thr Lys  Met Gln Glu 
    1220                 1225                 1230             


Ile Met  Arg Leu Ala His Glu  Phe Leu Gln Asn Phe  Cys Ala Gly 
    1235                 1240                 1245             


Asn Gln  Gln Asn Gln Ala Leu  Leu His Lys His Ile  Asn Leu Phe 
    1250                 1255                 1260             


Leu Asn  Pro Gly Ile Leu Glu  Ala Val Thr Met Gln  His Ile Phe 
    1265                 1270                 1275             


Met Asn  Asn Phe Gln Leu Cys  Ser Glu Ile Asn Glu  Arg Val Val 
    1280                 1285                 1290             


Gln His  Phe Val His Cys Ile  Glu Thr His Gly Arg  Asn Val Gln 
    1295                 1300                 1305             


Tyr Ile  Lys Phe Leu Gln Thr  Ile Val Lys Ala Glu  Gly Lys Phe 
    1310                 1315                 1320             


Ile Lys  Lys Cys Gln Asp Met  Val Met Ala Glu Leu  Val Asn Ser 
    1325                 1330                 1335             


Gly Glu  Asp Val Leu Val Phe  Tyr Asn Asp Arg Ala  Ser Phe Gln 
    1340                 1345                 1350             


Thr Leu  Ile Gln Met Met Arg  Ser Glu Arg Asp Arg  Met Asp Glu 
    1355                 1360                 1365             


Asn Ser  Pro Leu Met Tyr His  Ile His Leu Val Glu  Leu Leu Ala 
    1370                 1375                 1380             


Val Cys  Thr Glu Gly Lys Asn  Val Tyr Thr Glu Ile  Lys Cys Asn 
    1385                 1390                 1395             


Ser Leu  Leu Pro Leu Asp Asp  Ile Val Arg Val Val  Thr His Glu 
    1400                 1405                 1410             


Asp Cys  Ile Pro Glu Val Lys  Ile Ala Tyr Ile Asn  Phe Leu Asn 
    1415                 1420                 1425             


His Cys  Tyr Val Asp Thr Glu  Val Glu Met Lys Glu  Ile Tyr Thr 
    1430                 1435                 1440             


Ser Asn  His Met Trp Lys Leu  Phe Glu Asn Phe Leu  Val Asp Ile 
    1445                 1450                 1455             


Cys Arg  Ala Cys Asn Asn Thr  Ser Asp Arg Lys His  Ala Asp Ser 
    1460                 1465                 1470             


Ile Leu  Glu Lys Tyr Val Thr  Glu Ile Val Met Ser  Ile Val Thr 
    1475                 1480                 1485             


Thr Phe  Phe Ser Ser Pro Phe  Ser Asp Gln Ser Thr  Thr Leu Gln 
    1490                 1495                 1500             


Thr Arg  Gln Pro Val Phe Val  Gln Leu Leu Gln Gly  Val Phe Arg 
    1505                 1510                 1515             


Val Tyr  His Cys Asn Trp Leu  Met Pro Ser Gln Lys  Ala Ser Val 
    1520                 1525                 1530             


Glu Ser  Cys Ile Arg Val Leu  Ser Asp Val Ala Lys  Ser Arg Ala 
    1535                 1540                 1545             


Ile Ala  Ile Pro Val Asp Leu  Asp Ser Gln Val Asn  Asn Leu Phe 
    1550                 1555                 1560             


Leu Lys  Ser His Ser Ile Val  Gln Lys Thr Ala Met  Asn Trp Arg 
    1565                 1570                 1575             


Leu Ser  Ala Arg Asn Ala Ala  Arg Arg Asp Ser Val  Leu Ala Ala 
    1580                 1585                 1590             


Ser Arg  Asp Tyr Arg Asn Ile  Ile Glu Arg Leu Gln  Asp Ile Val 
    1595                 1600                 1605             


Ser Ala  Leu Glu Asp Arg Leu  Arg Pro Leu Val Gln  Ala Glu Leu 
    1610                 1615                 1620             


Ser Val  Leu Val Asp Val Leu  His Arg Pro Glu Leu  Leu Phe Pro 
    1625                 1630                 1635             


Glu Asn  Thr Asp Ala Arg Arg  Lys Cys Glu Ser Gly  Gly Phe Ile 
    1640                 1645                 1650             


Cys Lys  Leu Ile Lys His Thr  Lys Gln Leu Leu Glu  Glu Asn Glu 
    1655                 1660                 1665             


Glu Lys  Leu Cys Ile Lys Val  Leu Gln Thr Leu Arg  Glu Met Met 
    1670                 1675                 1680             


Thr Lys  Asp Arg Gly Tyr Gly  Glu Lys Gly Glu Ala  Leu Arg Gln 
    1685                 1690                 1695             


Val Leu  Val Asn Arg Tyr Tyr  Gly Asn Val Arg Pro  Ser Gly Arg 
    1700                 1705                 1710             


Arg Glu  Ser Leu Thr Ser Phe  Gly Asn Gly Pro Leu  Ser Ala Gly 
    1715                 1720                 1725             


Gly Pro  Gly Lys Pro Gly Gly  Gly Gly Gly Gly Ser  Gly Ser Ser 
    1730                 1735                 1740             


Ser Met  Ser Arg Gly Glu Met  Ser Leu Ala Glu Val  Gln Cys His 
    1745                 1750                 1755             


Leu Asp  Lys Glu Gly Ala Ser  Asn Leu Val Ile Asp  Leu Ile Met 
    1760                 1765                 1770             


Asn Ala  Ser Ser Asp Arg Val  Phe His Glu Ser Ile  Leu Leu Ala 
    1775                 1780                 1785             


Ile Ala  Leu Leu Glu Gly Gly  Asn Thr Thr Ile Gln  His Ser Phe 
    1790                 1795                 1800             


Phe Cys  Arg Leu Thr Glu Asp  Lys Lys Ser Glu Lys  Phe Phe Lys 
    1805                 1810                 1815             


Val Phe  Tyr Asp Arg Met Lys  Val Ala Gln Gln Glu  Ile Lys Ala 
    1820                 1825                 1830             


Thr Val  Thr Val Asn Thr Ser  Asp Leu Gly Asn Lys  Lys Lys Asp 
    1835                 1840                 1845             


Asp Glu  Val Asp Arg Asp Ala  Pro Ser Arg Lys Lys  Ala Lys Glu 
    1850                 1855                 1860             


Pro Thr  Thr Gln Ile Thr Glu  Glu Val Arg Asp Gln  Leu Leu Glu 
    1865                 1870                 1875             


Ala Ser  Ala Ala Thr Arg Lys  Ala Phe Thr Thr Phe  Arg Arg Glu 
    1880                 1885                 1890             


Ala Asp  Pro Asp Asp His Tyr  Gln Pro Gly Glu Gly  Thr Gln Ala 
    1895                 1900                 1905             


Thr Ala  Asp Lys Ala Lys Asp  Asp Leu Glu Met Ser  Ala Val Ile 
    1910                 1915                 1920             


Thr Ile  Met Gln Pro Ile Leu  Arg Phe Leu Gln Leu  Leu Cys Glu 
    1925                 1930                 1935             


Asn His  Asn Arg Asp Leu Gln  Asn Phe Leu Arg Cys  Gln Asn Asn 
    1940                 1945                 1950             


Lys Thr  Asn Tyr Asn Leu Val  Cys Glu Thr Leu Gln  Phe Leu Asp 
    1955                 1960                 1965             


Cys Ile  Cys Gly Ser Thr Thr  Gly Gly Leu Gly Leu  Leu Gly Leu 
    1970                 1975                 1980             


Tyr Ile  Asn Glu Lys Asn Val  Ala Leu Ile Asn Gln  Thr Leu Glu 
    1985                 1990                 1995             


Ser Leu  Thr Glu Tyr Cys Gln  Gly Pro Cys His Glu  Asn Gln Asn 
    2000                 2005                 2010             


Cys Ile  Ala Thr His Glu Ser  Asn Gly Ile Asp Ile  Ile Thr Ala 
    2015                 2020                 2025             


Leu Ile  Leu Asn Asp Ile Asn  Pro Leu Gly Lys Lys  Arg Met Asp 
    2030                 2035                 2040             


Leu Val  Leu Glu Leu Lys Asn  Asn Ala Ser Lys Leu  Leu Leu Ala 
    2045                 2050                 2055             


Ile Met  Glu Ser Arg His Asp  Ser Glu Asn Ala Glu  Arg Ile Leu 
    2060                 2065                 2070             


Tyr Asn  Met Arg Pro Lys Glu  Leu Val Glu Val Ile  Lys Lys Ala 
    2075                 2080                 2085             


Tyr Met  Gln Gly Glu Val Glu  Phe Glu Asp Gly Glu  Asn Gly Glu 
    2090                 2095                 2100             


Asp Gly  Ala Ala Ser Pro Arg  Asn Val Gly His Asn  Ile Tyr Ile 
    2105                 2110                 2115             


Leu Ala  His Gln Leu Ala Arg  His Asn Lys Glu Leu  Gln Ser Met 
    2120                 2125                 2130             


Leu Lys  Pro Gly Gly Gln Val  Asp Gly Asp Glu Ala  Leu Glu Phe 
    2135                 2140                 2145             


Tyr Ala  Lys His Thr Ala Gln  Ile Glu Ile Val Arg  Leu Asp Arg 
    2150                 2155                 2160             


Thr Met  Glu Gln Ile Val Phe  Pro Val Pro Ser Ile  Cys Glu Phe 
    2165                 2170                 2175             


Leu Thr  Lys Glu Ser Lys Leu  Arg Ile Tyr Tyr Thr  Thr Glu Arg 
    2180                 2185                 2190             


Asp Glu  Gln Gly Ser Lys Ile  Asn Asp Phe Phe Leu  Arg Ser Glu 
    2195                 2200                 2205             


Asp Leu  Phe Asn Glu Met Asn  Trp Gln Lys Lys Leu  Arg Ala Gln 
    2210                 2215                 2220             


Pro Val  Leu Tyr Trp Cys Ala  Arg Asn Met Ser Phe  Trp Ser Ser 
    2225                 2230                 2235             


Ile Ser  Phe Asn Leu Ala Val  Leu Met Asn Leu Leu  Val Ala Phe 
    2240                 2245                 2250             


Phe Tyr  Pro Phe Lys Gly Val  Arg Gly Gly Thr Leu  Glu Pro His 
    2255                 2260                 2265             


Trp Ser  Gly Leu Leu Trp Thr  Ala Met Leu Ile Ser  Leu Ala Ile 
    2270                 2275                 2280             


Val Ile  Ala Leu Pro Lys Pro  His Gly Ile Arg Ala  Leu Ile Ala 
    2285                 2290                 2295             


Ser Thr  Ile Leu Arg Leu Ile  Phe Ser Val Gly Leu  Gln Pro Thr 
    2300                 2305                 2310             


Leu Phe  Leu Leu Gly Ala Phe  Asn Val Cys Asn Lys  Ile Ile Phe 
    2315                 2320                 2325             


Leu Met  Ser Phe Val Gly Asn  Cys Gly Thr Phe Thr  Arg Gly Tyr 
    2330                 2335                 2340             


Arg Ala  Met Val Leu Asp Val  Glu Phe Leu Tyr His  Leu Leu Tyr 
    2345                 2350                 2355             


Leu Val  Ile Cys Ala Met Gly  Leu Phe Val His Glu  Phe Phe Tyr 
    2360                 2365                 2370             


Ser Leu  Leu Leu Phe Asp Leu  Val Tyr Arg Glu Glu  Thr Leu Leu 
    2375                 2380                 2385             


Asn Val  Ile Lys Ser Val Thr  Arg Asn Gly Arg Ser  Ile Ile Leu 
    2390                 2395                 2400             


Thr Ala  Val Leu Ala Leu Ile  Leu Val Tyr Leu Phe  Ser Ile Val 
    2405                 2410                 2415             


Gly Tyr  Leu Phe Phe Lys Asp  Asp Phe Ile Leu Glu  Val Asp Arg 
    2420                 2425                 2430             


Leu Pro  Asn Glu Thr Ala Val  Pro Glu Thr Gly Glu  Ser Leu Ala 
    2435                 2440                 2445             


Ser Glu  Phe Leu Phe Ser Asp  Val Cys Arg Val Glu  Ser Gly Glu 
    2450                 2455                 2460             


Asn Cys  Ser Ser Pro Ala Pro  Arg Glu Glu Leu Val  Pro Ala Glu 
    2465                 2470                 2475             


Glu Thr  Glu Gln Asp Lys Glu  His Thr Cys Glu Thr  Leu Leu Met 
    2480                 2485                 2490             


Cys Ile  Val Thr Val Leu Ser  His Gly Leu Arg Ser  Gly Gly Gly 
    2495                 2500                 2505             


Val Gly  Asp Val Leu Arg Lys  Pro Ser Lys Glu Glu  Pro Leu Phe 
    2510                 2515                 2520             


Ala Ala  Arg Val Ile Tyr Asp  Leu Leu Phe Phe Phe  Met Val Ile 
    2525                 2530                 2535             


Ile Ile  Val Leu Asn Leu Ile  Phe Gly Val Ile Ile  Asp Thr Phe 
    2540                 2545                 2550             


Ala Asp  Leu Arg Ser Glu Lys  Gln Lys Lys Glu Glu  Ile Leu Lys 
    2555                 2560                 2565             


Thr Thr  Cys Phe Ile Cys Gly  Leu Glu Arg Asp Lys  Phe Asp Asn 
    2570                 2575                 2580             


Lys Thr  Val Thr Phe Glu Glu  His Ile Lys Glu Glu  His Asn Met 
    2585                 2590                 2595             


Trp His  Tyr Leu Cys Phe Ile  Val Leu Val Lys Val  Lys Asp Ser 
    2600                 2605                 2610             


Thr Glu  Tyr Thr Gly Pro Glu  Ser Tyr Val Ala Glu  Met Ile Lys 
    2615                 2620                 2625             


Glu Arg  Asn Leu Asp Trp Phe  Pro Arg Met Arg Ala  Met Ser Leu 
    2630                 2635                 2640             


Val Ser  Ser Asp Ser Glu Gly  Glu Gln Asn Glu Leu  Arg Asn Leu 
    2645                 2650                 2655             


Gln Glu  Lys Leu Glu Ser Thr  Met Lys Leu Val Thr  Asn Leu Ser 
    2660                 2665                 2670             


Gly Gln  Leu Ser Glu Leu Lys  Asp Gln Met Thr Glu  Gln Arg Lys 
    2675                 2680                 2685             


Gln Lys  Gln Arg Ile Gly Leu  Leu Gly His Pro Pro  His Met Asn 
    2690                 2695                 2700             


Val Asn  Pro Gln Gln Pro Ala  
    2705                 2710 


<210>  1180
<211>  811
<212>  PRT
<213>  Homo sapiens

<400>  1180

Met Asn Val Ala Leu Gln Glu Leu Gly Ala Gly Ser Asn Met Val Glu 
1               5                   10                  15      


Tyr Lys Arg Ala Thr Leu Arg Asp Glu Asp Ala Pro Glu Thr Pro Val 
            20                  25                  30          


Glu Gly Gly Ala Ser Pro Asp Ala Met Glu Val Gly Lys Gly Ala Ser 
        35                  40                  45              


Pro Phe Ser Pro Gly Pro Ser Pro Gly Met Thr Pro Gly Thr Pro Arg 
    50                  55                  60                  


Ser Ser Gly Leu Phe Trp Arg Val Thr Cys Pro His Leu Arg Ser Ile 
65                  70                  75                  80  


Ser Gly Leu Cys Ser Arg Thr Met Val Gly Phe Gln Lys Gly Thr Arg 
                85                  90                  95      


Gln Leu Leu Gly Ser Arg Thr Gln Leu Glu Leu Val Leu Ala Gly Ala 
            100                 105                 110         


Ser Leu Leu Leu Ala Ala Leu Leu Leu Gly Cys Leu Val Ala Leu Gly 
        115                 120                 125             


Val Gln Tyr His Arg Asp Pro Ser His Ser Thr Cys Leu Thr Glu Ala 
    130                 135                 140                 


Cys Ile Arg Val Ala Gly Lys Ile Leu Glu Ser Leu Asp Arg Gly Val 
145                 150                 155                 160 


Ser Pro Cys Glu Asp Phe Tyr Gln Phe Ser Cys Gly Gly Trp Ile Arg 
                165                 170                 175     


Arg Asn Pro Leu Pro Asp Gly Arg Ser Arg Trp Asn Thr Phe Asn Ser 
            180                 185                 190         


Leu Trp Asp Gln Asn Gln Ala Ile Leu Lys His Leu Leu Glu Asn Thr 
        195                 200                 205             


Thr Phe Asn Ser Ser Ser Glu Ala Glu Gln Lys Thr Gln Arg Phe Tyr 
    210                 215                 220                 


Leu Ser Cys Leu Gln Val Glu Arg Ile Glu Glu Leu Gly Ala Gln Pro 
225                 230                 235                 240 


Leu Arg Asp Leu Ile Glu Lys Ile Gly Gly Trp Asn Ile Thr Gly Pro 
                245                 250                 255     


Trp Asp Gln Asp Asn Phe Met Glu Val Leu Lys Ala Val Ala Gly Thr 
            260                 265                 270         


Tyr Arg Ala Thr Pro Phe Phe Thr Val Tyr Ile Ser Ala Asp Ser Lys 
        275                 280                 285             


Ser Ser Asn Ser Asn Val Ile Gln Val Asp Gln Ser Gly Leu Phe Leu 
    290                 295                 300                 


Pro Ser Arg Asp Tyr Tyr Leu Asn Arg Thr Ala Asn Glu Lys Val Leu 
305                 310                 315                 320 


Thr Ala Tyr Leu Asp Tyr Met Glu Glu Leu Gly Met Leu Leu Gly Gly 
                325                 330                 335     


Arg Pro Thr Ser Thr Arg Glu Gln Met Gln Gln Val Leu Glu Leu Glu 
            340                 345                 350         


Ile Gln Leu Ala Asn Ile Thr Val Pro Gln Asp Gln Arg Arg Asp Glu 
        355                 360                 365             


Glu Lys Ile Tyr His Lys Met Ser Ile Ser Glu Leu Gln Ala Leu Ala 
    370                 375                 380                 


Pro Ser Met Asp Trp Leu Glu Phe Leu Ser Phe Leu Leu Ser Pro Leu 
385                 390                 395                 400 


Glu Leu Ser Asp Ser Glu Pro Val Val Val Tyr Gly Met Asp Tyr Leu 
                405                 410                 415     


Gln Gln Val Ser Glu Leu Ile Asn Arg Thr Glu Pro Ser Ile Leu Asn 
            420                 425                 430         


Asn Tyr Leu Ile Trp Asn Leu Val Gln Lys Thr Thr Ser Ser Leu Asp 
        435                 440                 445             


Arg Arg Phe Glu Ser Ala Gln Glu Lys Leu Leu Glu Thr Leu Tyr Gly 
    450                 455                 460                 


Thr Lys Lys Ser Cys Val Pro Arg Trp Gln Thr Cys Ile Ser Asn Thr 
465                 470                 475                 480 


Asp Asp Ala Leu Gly Phe Ala Leu Gly Ser Leu Phe Val Lys Ala Thr 
                485                 490                 495     


Phe Asp Arg Gln Ser Lys Glu Ile Ala Glu Gly Met Ile Ser Glu Ile 
            500                 505                 510         


Arg Thr Ala Phe Glu Glu Ala Leu Gly Gln Leu Val Trp Met Asp Glu 
        515                 520                 525             


Lys Thr Arg Gln Ala Ala Lys Glu Lys Ala Asp Ala Ile Tyr Asp Met 
    530                 535                 540                 


Ile Gly Phe Pro Asp Phe Ile Leu Glu Pro Lys Glu Leu Asp Asp Val 
545                 550                 555                 560 


Tyr Asp Gly Tyr Glu Ile Ser Glu Asp Ser Phe Phe Gln Asn Met Leu 
                565                 570                 575     


Asn Leu Tyr Asn Phe Ser Ala Lys Val Met Ala Asp Gln Leu Arg Lys 
            580                 585                 590         


Pro Pro Ser Arg Asp Gln Trp Ser Met Thr Pro Gln Thr Val Asn Ala 
        595                 600                 605             


Tyr Tyr Leu Pro Thr Lys Asn Glu Ile Val Phe Pro Ala Gly Ile Leu 
    610                 615                 620                 


Gln Ala Pro Phe Tyr Ala Arg Asn His Pro Lys Ala Leu Asn Phe Gly 
625                 630                 635                 640 


Gly Ile Gly Val Val Met Gly His Glu Leu Thr His Ala Phe Asp Asp 
                645                 650                 655     


Gln Gly Arg Glu Tyr Asp Lys Glu Gly Asn Leu Arg Pro Trp Trp Gln 
            660                 665                 670         


Asn Glu Ser Leu Ala Ala Phe Arg Asn His Thr Ala Cys Met Glu Glu 
        675                 680                 685             


Gln Tyr Asn Gln Tyr Gln Val Asn Gly Glu Arg Leu Asn Gly Arg Gln 
    690                 695                 700                 


Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Lys Ala Ala Tyr 
705                 710                 715                 720 


Asn Ala Tyr Lys Ala Trp Leu Arg Lys His Gly Glu Glu Gln Gln Leu 
                725                 730                 735     


Pro Ala Val Gly Leu Thr Asn His Gln Leu Phe Phe Val Gly Phe Ala 
            740                 745                 750         


Gln Val Trp Cys Ser Val Arg Thr Pro Glu Ser Ser His Glu Gly Leu 
        755                 760                 765             


Val Thr Asp Pro His Ser Pro Ala Arg Phe Arg Val Leu Gly Thr Leu 
    770                 775                 780                 


Ser Asn Ser Arg Asp Phe Leu Arg His Phe Gly Cys Pro Val Gly Ser 
785                 790                 795                 800 


Pro Met Asn Pro Gly Gln Leu Cys Glu Val Trp 
                805                 810     


<210>  1181
<211>  765
<212>  PRT
<213>  Homo sapiens

<400>  1181

Met Asn Val Ala Leu Gln Glu Leu Gly Ala Gly Ser Asn Met Val Glu 
1               5                   10                  15      


Tyr Lys Arg Ala Thr Leu Arg Asp Glu Asp Ala Pro Glu Thr Pro Val 
            20                  25                  30          


Glu Gly Gly Ala Ser Pro Asp Ala Met Glu Val Gly Phe Gln Lys Gly 
        35                  40                  45              


Thr Arg Gln Leu Leu Gly Ser Arg Thr Gln Leu Glu Leu Val Leu Ala 
    50                  55                  60                  


Gly Ala Ser Leu Leu Leu Ala Ala Leu Leu Leu Gly Cys Leu Val Ala 
65                  70                  75                  80  


Leu Gly Val Gln Tyr His Arg Asp Pro Ser His Ser Thr Cys Leu Thr 
                85                  90                  95      


Glu Ala Cys Ile Arg Val Ala Gly Lys Ile Leu Glu Ser Leu Asp Arg 
            100                 105                 110         


Gly Val Ser Pro Cys Glu Asp Phe Tyr Gln Phe Ser Cys Gly Gly Trp 
        115                 120                 125             


Ile Arg Arg Asn Pro Leu Pro Asp Gly Arg Ser Arg Trp Asn Thr Phe 
    130                 135                 140                 


Asn Ser Leu Trp Asp Gln Asn Gln Ala Ile Leu Lys His Leu Leu Glu 
145                 150                 155                 160 


Asn Thr Thr Phe Asn Ser Ser Ser Glu Ala Glu Gln Lys Thr Gln Arg 
                165                 170                 175     


Phe Tyr Leu Ser Cys Leu Gln Val Glu Arg Ile Glu Glu Leu Gly Ala 
            180                 185                 190         


Gln Pro Leu Arg Asp Leu Ile Glu Lys Ile Gly Gly Trp Asn Ile Thr 
        195                 200                 205             


Gly Pro Trp Asp Gln Asp Asn Phe Met Glu Val Leu Lys Ala Val Ala 
    210                 215                 220                 


Gly Thr Tyr Arg Ala Thr Pro Phe Phe Thr Val Tyr Ile Ser Ala Asp 
225                 230                 235                 240 


Ser Lys Ser Ser Asn Ser Asn Val Ile Gln Val Asp Gln Ser Gly Leu 
                245                 250                 255     


Phe Leu Pro Ser Arg Asp Tyr Tyr Leu Asn Arg Thr Ala Asn Glu Lys 
            260                 265                 270         


Val Leu Thr Ala Tyr Leu Asp Tyr Met Glu Glu Leu Gly Met Leu Leu 
        275                 280                 285             


Gly Gly Arg Pro Thr Ser Thr Arg Glu Gln Met Gln Gln Val Leu Glu 
    290                 295                 300                 


Leu Glu Ile Gln Leu Ala Asn Ile Thr Val Pro Gln Asp Gln Arg Arg 
305                 310                 315                 320 


Asp Glu Glu Lys Ile Tyr His Lys Met Ser Ile Ser Glu Leu Gln Ala 
                325                 330                 335     


Leu Ala Pro Ser Met Asp Trp Leu Glu Phe Leu Ser Phe Leu Leu Ser 
            340                 345                 350         


Pro Leu Glu Leu Ser Asp Ser Glu Pro Val Val Val Tyr Gly Met Asp 
        355                 360                 365             


Tyr Leu Gln Gln Val Ser Glu Leu Ile Asn Arg Thr Glu Pro Ser Ile 
    370                 375                 380                 


Leu Asn Asn Tyr Leu Ile Trp Asn Leu Val Gln Lys Thr Thr Ser Ser 
385                 390                 395                 400 


Leu Asp Arg Arg Phe Glu Ser Ala Gln Glu Lys Leu Leu Glu Thr Leu 
                405                 410                 415     


Tyr Gly Thr Lys Lys Ser Cys Val Pro Arg Trp Gln Thr Cys Ile Ser 
            420                 425                 430         


Asn Thr Asp Asp Ala Leu Gly Phe Ala Leu Gly Ser Leu Phe Val Lys 
        435                 440                 445             


Ala Thr Phe Asp Arg Gln Ser Lys Glu Ile Ala Glu Gly Met Ile Ser 
    450                 455                 460                 


Glu Ile Arg Thr Ala Phe Glu Glu Ala Leu Gly Gln Leu Val Trp Met 
465                 470                 475                 480 


Asp Glu Lys Thr Arg Gln Ala Ala Lys Glu Lys Ala Asp Ala Ile Tyr 
                485                 490                 495     


Asp Met Ile Gly Phe Pro Asp Phe Ile Leu Glu Pro Lys Glu Leu Asp 
            500                 505                 510         


Asp Val Tyr Asp Gly Tyr Glu Ile Ser Glu Asp Ser Phe Phe Gln Asn 
        515                 520                 525             


Met Leu Asn Leu Tyr Asn Phe Ser Ala Lys Val Met Ala Asp Gln Leu 
    530                 535                 540                 


Arg Lys Pro Pro Ser Arg Asp Gln Trp Ser Met Thr Pro Gln Thr Val 
545                 550                 555                 560 


Asn Ala Tyr Tyr Leu Pro Thr Lys Asn Glu Ile Val Phe Pro Ala Gly 
                565                 570                 575     


Ile Leu Gln Ala Pro Phe Tyr Ala Arg Asn His Pro Lys Ala Leu Asn 
            580                 585                 590         


Phe Gly Gly Ile Gly Val Val Met Gly His Glu Leu Thr His Ala Phe 
        595                 600                 605             


Asp Asp Gln Gly Arg Glu Tyr Asp Lys Glu Gly Asn Leu Arg Pro Trp 
    610                 615                 620                 


Trp Gln Asn Glu Ser Leu Ala Ala Phe Arg Asn His Thr Ala Cys Met 
625                 630                 635                 640 


Glu Glu Gln Tyr Asn Gln Tyr Gln Val Asn Gly Glu Arg Leu Asn Gly 
                645                 650                 655     


Arg Gln Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Lys Ala 
            660                 665                 670         


Ala Tyr Asn Ala Tyr Lys Ala Trp Leu Arg Lys His Gly Glu Glu Gln 
        675                 680                 685             


Gln Leu Pro Ala Val Gly Leu Thr Asn His Gln Leu Phe Phe Val Gly 
    690                 695                 700                 


Phe Ala Gln Val Trp Cys Ser Val Arg Thr Pro Glu Ser Ser His Glu 
705                 710                 715                 720 


Gly Leu Val Thr Asp Pro His Ser Pro Ala Arg Phe Arg Val Leu Gly 
                725                 730                 735     


Thr Leu Ser Asn Ser Arg Asp Phe Leu Arg His Phe Gly Cys Pro Val 
            740                 745                 750         


Gly Ser Pro Met Asn Pro Gly Gln Leu Cys Glu Val Trp 
        755                 760                 765 


<210>  1182
<211>  821
<212>  PRT
<213>  Homo sapiens

<400>  1182

Met Thr Gly Asp Ala Thr Ser Pro Glu Gly Glu Thr Asp Lys Asn Leu 
1               5                   10                  15      


Ala Asn Arg Val His Ser Pro His Lys Arg Leu Ser His Arg His Leu 
            20                  25                  30          


Lys Val Ser Thr Ala Ser Leu Thr Ser Val Asp Pro Ala Gly His Ile 
        35                  40                  45              


Ile Asp Leu Val Asn Asp Gln Leu Pro Asp Ile Ser Ile Ser Glu Glu 
    50                  55                  60                  


Asp Lys Lys Lys Asn Leu Ala Leu Leu Glu Glu Ala Lys Leu Val Ser 
65                  70                  75                  80  


Glu Arg Phe Leu Thr Arg Arg Gly Arg Lys Ser Arg Ser Ser Pro Gly 
                85                  90                  95      


Asp Ser Pro Ser Ala Val Ser Pro Asn Leu Ser Pro Ser Ala Ser Pro 
            100                 105                 110         


Thr Ser Ser Arg Ser Asn Ser Leu Thr Val Pro Thr Pro Pro Gly Leu 
        115                 120                 125             


Asp Val Cys Ser Gly Pro Pro Ser Pro Leu Pro Gly Ala Pro Pro Gln 
    130                 135                 140                 


Lys Gly Asp Glu Ala Asp Val Ser Ser Pro His Pro Gly Glu Pro Asn 
145                 150                 155                 160 


Val Pro Lys Gly Leu Ala Asp Arg Lys Gln Asn Asp Gln Arg Lys Val 
                165                 170                 175     


Ser Gln Gly Arg Leu Ala Pro Arg Pro Pro Pro Val Glu Lys Ser Lys 
            180                 185                 190         


Glu Ile Ala Ile Glu Gln Lys Glu Asn Phe Asp Pro Leu Gln Tyr Pro 
        195                 200                 205             


Glu Thr Thr Pro Lys Gly Leu Ala Pro Val Thr Asn Ser Ser Gly Lys 
    210                 215                 220                 


Met Ala Leu Asn Ser Pro Gln Pro Gly Pro Val Glu Ser Glu Leu Gly 
225                 230                 235                 240 


Lys Gln Leu Leu Lys Thr Gly Trp Glu Gly Ser Pro Leu Pro Arg Ser 
                245                 250                 255     


Pro Thr Gln Asp Ala Ala Gly Val Gly Pro Pro Ala Ser Gln Gly Arg 
            260                 265                 270         


Gly Pro Ala Gly Glu Pro Met Gly Pro Glu Ala Gly Ser Lys Ala Glu 
        275                 280                 285             


Leu Pro Pro Thr Val Ser Arg Pro Pro Leu Leu Arg Gly Leu Ser Trp 
    290                 295                 300                 


Asp Ser Gly Pro Glu Glu Pro Gly Pro Arg Leu Gln Lys Val Leu Ala 
305                 310                 315                 320 


Lys Leu Pro Leu Ala Glu Glu Glu Lys Arg Phe Ala Gly Lys Ala Gly 
                325                 330                 335     


Gly Lys Leu Ala Lys Ala Pro Gly Leu Lys Asp Phe Gln Ile Gln Val 
            340                 345                 350         


Gln Pro Val Arg Met Gln Lys Leu Thr Lys Leu Arg Glu Glu His Ile 
        355                 360                 365             


Leu Met Arg Asn Gln Asn Leu Val Gly Leu Lys Leu Pro Asp Leu Ser 
    370                 375                 380                 


Glu Ala Ala Glu Gln Glu Lys Gly Leu Pro Ser Glu Leu Ser Pro Ala 
385                 390                 395                 400 


Ile Glu Glu Glu Glu Ser Lys Ser Gly Leu Asp Val Met Pro Asn Ile 
                405                 410                 415     


Ser Asp Val Leu Leu Arg Lys Leu Arg Val His Arg Ser Leu Pro Gly 
            420                 425                 430         


Ser Ala Pro Pro Leu Thr Glu Lys Glu Val Glu Asn Val Phe Val Gln 
        435                 440                 445             


Leu Ser Leu Ala Phe Arg Asn Asp Ser Tyr Thr Leu Glu Ser Arg Ile 
    450                 455                 460                 


Asn Gln Ala Glu Arg Glu Arg Asn Leu Thr Glu Glu Asn Thr Glu Lys 
465                 470                 475                 480 


Glu Leu Glu Asn Phe Lys Ala Ser Ile Thr Ser Ser Ala Ser Leu Trp 
                485                 490                 495     


His His Cys Glu His Arg Glu Thr Tyr Gln Lys Leu Leu Glu Asp Ile 
            500                 505                 510         


Ala Val Leu His Arg Leu Ala Ala Arg Leu Ser Ser Arg Ala Glu Val 
        515                 520                 525             


Val Gly Ala Val Arg Gln Glu Lys Arg Met Ser Lys Ala Thr Glu Val 
    530                 535                 540                 


Met Met Gln Tyr Val Glu Asn Leu Lys Arg Thr Tyr Glu Lys Asp His 
545                 550                 555                 560 


Ala Glu Leu Met Glu Phe Lys Lys Leu Ala Asn Gln Asn Ser Ser Arg 
                565                 570                 575     


Ser Cys Gly Pro Ser Glu Asp Gly Val Pro Arg Thr Ala Arg Ser Met 
            580                 585                 590         


Ser Leu Thr Leu Gly Lys Asn Met Pro Arg Arg Arg Val Ser Val Ala 
        595                 600                 605             


Val Val Pro Lys Phe Asn Ala Leu Asn Leu Pro Gly Gln Thr Pro Ser 
    610                 615                 620                 


Ser Ser Ser Ile Pro Ser Leu Pro Ala Leu Ser Glu Ser Pro Asn Gly 
625                 630                 635                 640 


Lys Gly Ser Leu Pro Val Thr Ser Ala Leu Pro Ala Leu Leu Glu Asn 
                645                 650                 655     


Gly Lys Thr Asn Gly Asp Pro Asp Cys Glu Ala Ser Ala Pro Ala Leu 
            660                 665                 670         


Thr Leu Ser Cys Leu Glu Glu Leu Ser Gln Glu Thr Lys Ala Arg Met 
        675                 680                 685             


Glu Glu Glu Ala Tyr Ser Lys Gly Phe Gln Glu Gly Leu Lys Lys Thr 
    690                 695                 700                 


Lys Glu Leu Gln Asp Leu Lys Glu Glu Glu Glu Glu Gln Lys Ser Glu 
705                 710                 715                 720 


Ser Pro Glu Glu Pro Glu Glu Val Glu Glu Thr Glu Glu Glu Glu Lys 
                725                 730                 735     


Gly Pro Arg Ser Ser Lys Leu Glu Glu Leu Val His Phe Leu Gln Val 
            740                 745                 750         


Met Tyr Pro Lys Leu Cys Gln His Trp Gln Val Ile Trp Met Met Ala 
        755                 760                 765             


Ala Val Met Leu Val Leu Thr Val Val Leu Gly Leu Tyr Asn Ser Tyr 
    770                 775                 780                 


Asn Ser Cys Ala Glu Gln Ala Asp Gly Pro Leu Gly Arg Ser Thr Cys 
785                 790                 795                 800 


Ser Ala Ala Gln Arg Asp Ser Trp Trp Ser Ser Gly Leu Gln His Glu 
                805                 810                 815     


Gln Pro Thr Glu Gln 
            820     


<210>  1183
<211>  597
<212>  PRT
<213>  Homo sapiens

<400>  1183

Met Ala Leu Asn Ser Pro Gln Pro Gly Pro Val Glu Ser Glu Leu Gly 
1               5                   10                  15      


Lys Gln Leu Leu Lys Thr Gly Trp Glu Gly Ser Pro Leu Pro Arg Ser 
            20                  25                  30          


Pro Thr Gln Asp Ala Ala Gly Val Gly Pro Pro Ala Ser Gln Gly Arg 
        35                  40                  45              


Gly Pro Ala Gly Glu Pro Met Gly Pro Glu Ala Gly Ser Lys Ala Glu 
    50                  55                  60                  


Leu Pro Pro Thr Val Ser Arg Pro Pro Leu Leu Arg Gly Leu Ser Trp 
65                  70                  75                  80  


Asp Ser Gly Pro Glu Glu Pro Gly Pro Arg Leu Gln Lys Val Leu Ala 
                85                  90                  95      


Lys Leu Pro Leu Ala Glu Glu Glu Lys Arg Phe Ala Gly Lys Ala Gly 
            100                 105                 110         


Gly Lys Leu Ala Lys Ala Pro Gly Leu Lys Asp Phe Gln Ile Gln Val 
        115                 120                 125             


Gln Pro Val Arg Met Gln Lys Leu Thr Lys Leu Arg Glu Glu His Ile 
    130                 135                 140                 


Leu Met Arg Asn Gln Asn Leu Val Gly Leu Lys Leu Pro Asp Leu Ser 
145                 150                 155                 160 


Glu Ala Ala Glu Gln Glu Lys Gly Leu Pro Ser Glu Leu Ser Pro Ala 
                165                 170                 175     


Ile Glu Glu Glu Glu Ser Lys Ser Gly Leu Asp Val Met Pro Asn Ile 
            180                 185                 190         


Ser Asp Val Leu Leu Arg Lys Leu Arg Val His Arg Ser Leu Pro Gly 
        195                 200                 205             


Ser Ala Pro Pro Leu Thr Glu Lys Glu Val Glu Asn Val Phe Val Gln 
    210                 215                 220                 


Leu Ser Leu Ala Phe Arg Asn Asp Ser Tyr Thr Leu Glu Ser Arg Ile 
225                 230                 235                 240 


Asn Gln Ala Glu Arg Glu Arg Asn Leu Thr Glu Glu Asn Thr Glu Lys 
                245                 250                 255     


Glu Leu Glu Asn Phe Lys Ala Ser Ile Thr Ser Ser Ala Ser Leu Trp 
            260                 265                 270         


His His Cys Glu His Arg Glu Thr Tyr Gln Lys Leu Leu Glu Asp Ile 
        275                 280                 285             


Ala Val Leu His Arg Leu Ala Ala Arg Leu Ser Ser Arg Ala Glu Val 
    290                 295                 300                 


Val Gly Ala Val Arg Gln Glu Lys Arg Met Ser Lys Ala Thr Glu Val 
305                 310                 315                 320 


Met Met Gln Tyr Val Glu Asn Leu Lys Arg Thr Tyr Glu Lys Asp His 
                325                 330                 335     


Ala Glu Leu Met Glu Phe Lys Lys Leu Ala Asn Gln Asn Ser Ser Arg 
            340                 345                 350         


Ser Cys Gly Pro Ser Glu Asp Gly Val Pro Arg Thr Ala Arg Ser Met 
        355                 360                 365             


Ser Leu Thr Leu Gly Lys Asn Met Pro Arg Arg Arg Val Ser Val Ala 
    370                 375                 380                 


Val Val Pro Lys Phe Asn Ala Leu Asn Leu Pro Gly Gln Thr Pro Ser 
385                 390                 395                 400 


Ser Ser Ser Ile Pro Ser Leu Pro Ala Leu Ser Glu Ser Pro Asn Gly 
                405                 410                 415     


Lys Gly Ser Leu Pro Val Thr Ser Ala Leu Pro Ala Leu Leu Glu Asn 
            420                 425                 430         


Gly Lys Thr Asn Gly Asp Pro Asp Cys Glu Ala Ser Ala Pro Ala Leu 
        435                 440                 445             


Thr Leu Ser Cys Leu Glu Glu Leu Ser Gln Glu Thr Lys Ala Arg Met 
    450                 455                 460                 


Glu Glu Glu Ala Tyr Ser Lys Gly Phe Gln Glu Gly Leu Lys Lys Thr 
465                 470                 475                 480 


Lys Glu Leu Gln Asp Leu Lys Glu Glu Glu Glu Glu Gln Lys Ser Glu 
                485                 490                 495     


Ser Pro Glu Glu Pro Glu Glu Val Glu Glu Thr Glu Glu Glu Glu Lys 
            500                 505                 510         


Gly Pro Arg Ser Ser Lys Leu Glu Glu Leu Val His Phe Leu Gln Val 
        515                 520                 525             


Met Tyr Pro Lys Leu Cys Gln His Trp Gln Val Ile Trp Met Met Ala 
    530                 535                 540                 


Ala Val Met Leu Val Leu Thr Val Val Leu Gly Leu Tyr Asn Ser Tyr 
545                 550                 555                 560 


Asn Ser Cys Ala Glu Gln Ala Asp Gly Pro Leu Gly Arg Ser Thr Cys 
                565                 570                 575     


Ser Ala Ala Gln Arg Asp Ser Trp Trp Ser Ser Gly Leu Gln His Glu 
            580                 585                 590         


Gln Pro Thr Glu Gln 
        595         


<210>  1184
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  1184

Met Asp Tyr Gln Val Ser Ser Pro Ile Tyr Asp Ile Asn Tyr Tyr Thr 
1               5                   10                  15      


Ser Glu Pro Cys Gln Lys Ile Asn Val Lys Gln Ile Ala Ala Arg Leu 
            20                  25                  30          


Leu Pro Pro Leu Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn 
        35                  40                  45              


Met Leu Val Ile Leu Ile Leu Ile Asn Cys Lys Arg Leu Lys Ser Met 
    50                  55                  60                  


Thr Asp Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp Leu Phe Phe Leu 
65                  70                  75                  80  


Leu Thr Val Pro Phe Trp Ala His Tyr Ala Ala Ala Gln Trp Asp Phe 
                85                  90                  95      


Gly Asn Thr Met Cys Gln Leu Leu Thr Gly Leu Tyr Phe Ile Gly Phe 
            100                 105                 110         


Phe Ser Gly Ile Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu 
        115                 120                 125             


Ala Val Val His Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe 
    130                 135                 140                 


Gly Val Val Thr Ser Val Ile Thr Trp Val Val Ala Val Phe Ala Ser 
145                 150                 155                 160 


Leu Pro Gly Ile Ile Phe Thr Arg Ser Gln Lys Glu Gly Leu His Tyr 
                165                 170                 175     


Thr Cys Ser Ser His Phe Pro Tyr Ser Gln Tyr Gln Phe Trp Lys Asn 
            180                 185                 190         


Phe Gln Thr Leu Lys Ile Val Ile Leu Gly Leu Val Leu Pro Leu Leu 
        195                 200                 205             


Val Met Val Ile Cys Tyr Ser Gly Ile Leu Lys Thr Leu Leu Arg Cys 
    210                 215                 220                 


Arg Asn Glu Lys Lys Arg His Arg Ala Val Arg Leu Ile Phe Thr Ile 
225                 230                 235                 240 


Met Ile Val Tyr Phe Leu Phe Trp Ala Pro Tyr Asn Ile Val Leu Leu 
                245                 250                 255     


Leu Asn Thr Phe Gln Glu Phe Phe Gly Leu Asn Asn Cys Ser Ser Ser 
            260                 265                 270         


Asn Arg Leu Asp Gln Ala Met Gln Val Thr Glu Thr Leu Gly Met Thr 
        275                 280                 285             


His Cys Cys Ile Asn Pro Ile Ile Tyr Ala Phe Val Gly Glu Lys Phe 
    290                 295                 300                 


Arg Asn Tyr Leu Leu Val Phe Phe Gln Lys His Ile Ala Lys Arg Phe 
305                 310                 315                 320 


Cys Lys Cys Cys Ser Ile Phe Gln Gln Glu Ala Pro Glu Arg Ala Ser 
                325                 330                 335     


Ser Val Tyr Thr Arg Ser Thr Gly Glu Gln Glu Ile Ser Val Gly Leu 
            340                 345                 350         


<210>  1185
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  1185

Met Ala Ala Gly Gly Arg Met Glu Asp Gly Ser Leu Asp Ile Thr Gln 
1               5                   10                  15      


Ser Ile Glu Asp Asp Pro Leu Leu Asp Ala Gln Leu Leu Pro His His 
            20                  25                  30          


Ser Leu Gln Ala His Phe Arg Pro Arg Phe His Pro Leu Pro Thr Val 
        35                  40                  45              


Ile Ile Val Asn Leu Leu Trp Phe Ile His Leu Val Phe Val Val Leu 
    50                  55                  60                  


Ala Phe Leu Thr Gly Val Leu Cys Ser Tyr Pro Asn Pro Asn Glu Asp 
65                  70                  75                  80  


Lys Cys Pro Gly Asn Tyr Thr Asn Pro Leu Lys Val Gln Thr Val Ile 
                85                  90                  95      


Ile Leu Gly Lys Val Ile Leu Trp Ile Leu His Leu Leu Leu Glu Cys 
            100                 105                 110         


Tyr Ile Gln Tyr His His Ser Lys Ile Arg Asn Arg Gly Tyr Asn Leu 
        115                 120                 125             


Ile Tyr Arg Ser Thr Arg His Leu Lys Arg Leu Ala Leu Met Ile Gln 
    130                 135                 140                 


Ser Ser Gly Asn Thr Val Leu Leu Leu Ile Leu Cys Met Gln His Ser 
145                 150                 155                 160 


Phe Pro Glu Pro Gly Arg Leu Tyr Leu Asp Leu Ile Leu Ala Ile Leu 
                165                 170                 175     


Ala Leu Glu Leu Ile Cys Ser Leu Ile Cys Leu Leu Ile Tyr Thr Val 
            180                 185                 190         


Lys Ile Arg Arg Phe Asn Lys Ala Lys Pro Glu Pro Asp Ile Leu Glu 
        195                 200                 205             


Glu Glu Lys Ile Tyr Ala Tyr Pro Ser Asn Ile Thr Ser Glu Thr Gly 
    210                 215                 220                 


Phe Arg Thr Ile Ser Ser Leu Glu Glu Ile Val Glu Lys Gln Gly Asp 
225                 230                 235                 240 


Thr Ile Glu Tyr Leu Lys Arg His Asn Ala Leu Leu Ser Lys Arg Leu 
                245                 250                 255     


Leu Ala Leu Thr Ser Ser Asp Leu Gly Cys Gln Pro Ser Arg Thr 
            260                 265                 270     


<210>  1186
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  1186

Met Tyr Leu Gln Val Glu Thr Arg Thr Ser Ser Arg Leu His Leu Lys 
1               5                   10                  15      


Arg Ala Pro Gly Ile Arg Ser Trp Ser Leu Leu Val Gly Ile Leu Ser 
            20                  25                  30          


Ile Gly Leu Ala Ala Ala Tyr Tyr Ser Gly Asp Ser Leu Gly Trp Lys 
        35                  40                  45              


Leu Phe Tyr Val Thr Gly Cys Leu Phe Val Ala Val Gln Asn Leu Glu 
    50                  55                  60                  


Asp Trp Glu Glu Ala Ile Phe Asp Lys Ser Thr Gly Lys Val Val Leu 
65                  70                  75                  80  


Lys Thr Phe Ser Leu Tyr Lys Lys Leu Leu Thr Leu Phe Arg Ala Gly 
                85                  90                  95      


His Asp Gln Val Val Val Leu Leu His Asp Val Arg Asp Val Ser Val 
            100                 105                 110         


Glu Glu Glu Lys Val Arg Tyr Phe Gly Lys Gly Tyr Met Val Val Leu 
        115                 120                 125             


Arg Leu Ala Thr Gly Phe Ser His Pro Leu Thr Gln Ser Ala Val Met 
    130                 135                 140                 


Gly His Arg Ser Asp Val Glu Ala Ile Ala Lys Leu Ile Thr Ser Phe 
145                 150                 155                 160 


Leu Glu Leu His Cys Leu Glu Ser Pro Thr Glu Leu Ser Gln Ser Ser 
                165                 170                 175     


Asp Ser Glu Ala Gly Asp Pro Ala Ser Gln Ser 
            180                 185         


<210>  1187
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  1187

Met Tyr Leu Gln Val Glu Thr Arg Thr Ser Ser Arg Leu His Leu Lys 
1               5                   10                  15      


Arg Ala Pro Gly Ile Arg Ser Trp Ser Leu Leu Val Asp Ser Leu Gly 
            20                  25                  30          


Trp Lys Leu Phe Tyr Val Thr Gly Cys Leu Phe Val Ala Val Gln Asn 
        35                  40                  45              


Leu Glu Asp Trp Glu Glu Ala Ile Phe Asp Lys Ser Thr Gly Lys Val 
    50                  55                  60                  


Val Leu Lys Thr Phe Ser Leu Tyr Lys Lys Leu Leu Thr Leu Phe Arg 
65                  70                  75                  80  


Ala Gly His Asp Gln Val Val Val Leu Leu His Asp Val Arg Asp Val 
                85                  90                  95      


Ser Val Glu Glu Glu Lys Val Arg Tyr Phe Gly Lys Gly Tyr Met Val 
            100                 105                 110         


Val Leu Arg Leu Ala Thr Gly Phe Ser His Pro Leu Thr Gln Ser Ala 
        115                 120                 125             


Val Met Gly His Arg Ser Asp Val Glu Ala Ile Ala Lys Leu Ile Thr 
    130                 135                 140                 


Ser Phe Leu Glu Leu His Cys Leu Glu Ser Pro Thr Glu Leu Ser Gln 
145                 150                 155                 160 


Ser Ser Asp Ser Glu Ala Gly Asp Pro Ala Ser Gln Ser 
                165                 170             


<210>  1188
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  1188

Met Gly Ile Leu Leu Gly Leu Leu Leu Leu Gly His Leu Thr Val Asp 
1               5                   10                  15      


Thr Tyr Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro 
            20                  25                  30          


Trp Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly 
        35                  40                  45              


Tyr Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro 
    50                  55                  60                  


Val Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala 
65                  70                  75                  80  


Lys Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val 
                85                  90                  95      


Ser Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr 
            100                 105                 110         


Cys Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp 
        115                 120                 125             


Lys Ile Thr Glu Leu Arg Val Gln Lys His Ser Ser Lys Leu Leu Lys 
    130                 135                 140                 


Thr Lys Thr Glu Ala Pro Thr Thr Met Thr Tyr Pro Leu Lys Ala Thr 
145                 150                 155                 160 


Ser Thr Val Lys Gln Ser Trp Asp Trp Thr Thr Asp Met Asp Gly Tyr 
                165                 170                 175     


Leu Gly Glu Thr Ser Ala Gly Pro Gly Lys Ser Leu Pro Val Phe Ala 
            180                 185                 190         


Ile Ile Leu Ile Ile Ser Leu Cys Cys Met Val Val Phe Thr Met Ala 
        195                 200                 205             


Tyr Ile Met Leu Cys Arg Lys Thr Ser Gln Gln Glu His Val Tyr Glu 
    210                 215                 220                 


Ala Ala Arg Ala His Ala Arg Glu Ala Asn Asp Ser Gly Glu Thr Met 
225                 230                 235                 240 


Arg Val Ala Ile Phe Ala Ser Gly Cys Ser Ser Asp Glu Pro Thr Ser 
                245                 250                 255     


Gln Asn Leu Gly Asn Asn Tyr Ser Asp Glu Pro Cys Ile Gly Gln Glu 
            260                 265                 270         


Tyr Gln Ile Ile Ala Gln Ile Asn Gly Asn Tyr Ala Arg Leu Leu Asp 
        275                 280                 285             


Thr Val Pro Leu Asp Tyr Glu Phe Leu Ala Thr Glu Gly Lys Ser Val 
    290                 295                 300                 


Cys 
305 


<210>  1189
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  1189

Met Arg Val Arg Gly Pro Ala Arg Leu Ile Ala Ser Gly Ala Arg Leu 
1               5                   10                  15      


Leu Leu Arg Met Leu Ser Ala Leu Pro Gly Trp Gly Pro Ala His Leu 
            20                  25                  30          


Gln Arg Pro Leu Leu Gly Pro Ala Ser Cys Leu Gly Ile Leu Arg Pro 
        35                  40                  45              


Ala Met Thr Ala His Ser Phe Ala Leu Pro Val Ile Ile Phe Thr Thr 
    50                  55                  60                  


Phe Trp Gly Leu Val Gly Ile Ala Gly Pro Trp Phe Val Pro Lys Gly 
65                  70                  75                  80  


Pro Asn Arg Gly Val Ile Ile Thr Met Leu Val Ala Thr Ala Val Cys 
                85                  90                  95      


Cys Tyr Leu Leu Cys Pro Ala Leu Gly Met Thr Val Ala Pro Leu Ser 
            100                 105                 110         


Leu Thr Thr Pro Ser Ser Gly Pro Ser Pro Thr Gln Leu Cys Leu Val 
        115                 120                 125             


Thr Ser Ser Leu Leu Leu Ala Pro Arg Asp Pro Asp Pro Gln Gly Leu 
    130                 135                 140                 


Pro Gly Ser Trp Lys Ser Ser Gln Ser Ser Gln Pro Ala Arg Ala Leu 
145                 150                 155                 160 


Gly Ser Pro Gly His Ser Ser Gly Arg Gly Asp Val Leu Leu Gln Tyr 
                165                 170                 175     


Pro His Cys Ser Gly Val Cys Pro Leu Ser Gln Gly Asp Ala Ala Gly 
            180                 185                 190         


Glu Leu Val Trp Val Gly Ser Phe Pro Leu Gln Thr Gly Gln Met Pro 
        195                 200                 205             


Gly Leu Ser Pro Ser 
    210             


<210>  1190
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  1190

Met Phe Ala Pro Arg Leu Leu Asp Phe Gln Lys Thr Lys Tyr Ala Arg 
1               5                   10                  15      


Phe Met Asn His Arg Val Pro Ala His Lys Arg Tyr Gln Pro Thr Glu 
            20                  25                  30          


Tyr Glu His Ala Ala Asn Cys Ala Thr His Ala Phe Trp Ile Ile Pro 
        35                  40                  45              


Ser Ile Leu Gly Ser Ser Asn Leu Tyr Phe Leu Ser Asp Asp Asp Trp 
    50                  55                  60                  


Glu Thr Ile Ser Ala Trp Ile Tyr Gly Leu Gly Leu Cys Gly Leu Phe 
65                  70                  75                  80  


Val Val Ser Thr Val Phe His Thr Ile Ser Trp Lys Lys Ser His Leu 
                85                  90                  95      


Arg Met Val Glu His Cys Leu His Met Phe Asp Arg Met Val Ile Tyr 
            100                 105                 110         


Phe Phe Ile Ala Ala Ser Tyr Ala Pro Trp Leu Asn Leu Arg Glu Leu 
        115                 120                 125             


Gly Pro Trp Ala Ser His Met Arg Trp Leu Val Trp Ile Met Ala Ser 
    130                 135                 140                 


Val Gly Thr Ile Tyr Val Phe Phe Phe His Glu Arg Thr Gly Ser Cys 
145                 150                 155                 160 


Val Gln Phe Leu Arg Gly Glu Ala Cys Pro Lys Ala Gly Thr Ala Cys 
                165                 170                 175     


Leu Pro Ala Arg Tyr Lys Leu Val Glu Leu Leu Cys Tyr Val Val Met 
            180                 185                 190         


Gly Phe Phe Pro Ala Leu Val Ile Leu Ser Met Pro Asn Thr Glu Gly 
        195                 200                 205             


Ile Trp Glu Leu Val Thr Gly Gly Val Phe Tyr Cys Leu Gly Met Val 
    210                 215                 220                 


Phe Phe Lys Ser Asp Gly Arg Ile Pro Phe Ala His Ala Ile Trp His 
225                 230                 235                 240 


Leu Phe Val Ala Phe Gly Ala Gly Thr His Tyr Tyr Ala Ile Trp Arg 
                245                 250                 255     


Tyr Leu Tyr Leu Pro Ser Thr Leu Gln Thr Lys Val Ser Lys 
            260                 265                 270 


<210>  1191
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  1191

Met Asn Ile Phe Arg Leu Thr Gly Asp Leu Ser His Leu Ala Ala Ile 
1               5                   10                  15      


Val Ile Leu Leu Leu Lys Ile Trp Lys Thr Arg Ser Cys Ala Gly Ile 
            20                  25                  30          


Ser Gly Lys Ser Gln Leu Leu Phe Ala Leu Val Phe Thr Thr Arg Tyr 
        35                  40                  45              


Leu Asp Leu Phe Thr Ser Phe Ile Ser Leu Tyr Asn Thr Ser Met Lys 
    50                  55                  60                  


Val Ile Tyr Leu Ala Cys Ser Tyr Ala Thr Val Tyr Leu Ile Tyr Leu 
65                  70                  75                  80  


Lys Phe Lys Ala Thr Tyr Asp Gly Asn His Asp Thr Phe Arg Val Glu 
                85                  90                  95      


Phe Leu Val Val Pro Val Gly Gly Leu Ser Phe Leu Val Asn His Asp 
            100                 105                 110         


Phe Ser Pro Leu Glu Tyr Ser Arg Glu Arg Ser Ser Val Cys Gln His 
        115                 120                 125             


Lys Cys Gln Arg Pro Ser Pro Ala Ser Val Leu Gln Gly Ala Arg Thr 
    130                 135                 140                 


Glu Phe Leu Pro Gln Gln Arg His Lys Met Leu Asp Thr Glu Asn Gln 
145                 150                 155                 160 


Lys Leu Asn Ser Phe Val Ala Asp Ser His Gln Trp Leu Cys Lys Asn 
                165                 170                 175     


Ala Glu Glu Lys Ser Gln Lys Val Ser Val 
            180                 185     


<210>  1192
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  1192

Met Asn Met Thr Gln Ala Arg Val Leu Val Ala Ala Val Val Gly Leu 
1               5                   10                  15      


Val Ala Val Leu Leu Tyr Ala Ser Ile His Lys Ile Glu Glu Gly His 
            20                  25                  30          


Leu Ala Val Tyr Tyr Arg Gly Gly Ala Leu Leu Thr Ser Pro Ser Gly 
        35                  40                  45              


Pro Gly Tyr His Ile Met Leu Pro Phe Ile Thr Thr Phe Arg Ser Val 
    50                  55                  60                  


Gln Thr Thr Leu Gln Thr Asp Glu Val Lys Asn Val Pro Cys Gly Thr 
65                  70                  75                  80  


Ser Gly Gly Val Met Ile Tyr Ile Asp Arg Ile Glu Val Val Asn Met 
                85                  90                  95      


Leu Ala Pro Tyr Ala Val Phe Asp Ile Val Arg Asn Tyr Thr Ala Asp 
            100                 105                 110         


Tyr Asp Lys Thr Leu Ile Phe Asn Lys Ile His His Glu Leu Asn Gln 
        115                 120                 125             


Phe Cys Ser Ala His Thr Leu Gln Glu Val Tyr Ile Glu Leu Phe Asp 
    130                 135                 140                 


Gln Ile Asp Glu Asn Leu Lys Gln Ala Leu Gln Lys Asp Leu Asn Leu 
145                 150                 155                 160 


Met Ala Pro Gly Leu Thr Ile Gln Ala Val Arg Val Thr Lys Pro Lys 
                165                 170                 175     


Ile Pro Glu Ala Ile Arg Arg Asn Phe Glu Leu Met Glu Ala Glu Lys 
            180                 185                 190         


Thr Lys Leu Leu Ile Ala Ala Gln Lys Gln Lys Val Val Glu Lys Glu 
        195                 200                 205             


Ala Glu Thr Glu Arg Lys Lys Ala Val Ile Glu Ala Glu Lys Ile Ala 
    210                 215                 220                 


Gln Val Ala Lys Ile Arg Phe Gln Gln Lys Val Met Glu Lys Glu Thr 
225                 230                 235                 240 


Glu Lys Arg Ile Ser Glu Ile Glu Asp Ala Ala Phe Leu Ala Arg Glu 
                245                 250                 255     


Lys Ala Lys Ala Asp Ala Glu Tyr Tyr Ala Ala His Lys Tyr Ala Thr 
            260                 265                 270         


Ser Asn Lys His Lys Leu Thr Pro Glu Tyr Leu Glu Leu Lys Lys Tyr 
        275                 280                 285             


Gln Ala Ile Ala Ser Asn Ser Lys Ile Tyr Phe Gly Ser Asn Ile Pro 
    290                 295                 300                 


Asn Met Phe Val Asp Ser Ser Cys Ala Leu Lys Tyr Ser Asp Ile Arg 
305                 310                 315                 320 


Thr Gly Arg Glu Ser Ser Leu Pro Ser Lys Glu Ala Leu Glu Pro Ser 
                325                 330                 335     


Gly Glu Asn Val Ile Gln Asn Lys Glu Ser Thr Gly 
            340                 345             


<210>  1193
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  1193

Met Ser Gly Ser Gln Ser Glu Val Ala Pro Ser Pro Gln Ser Pro Arg 
1               5                   10                  15      


Ser Pro Glu Met Gly Arg Asp Leu Arg Pro Gly Ser Arg Val Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Leu Leu Val Tyr Leu Thr Gln Pro Gly Asn Gly 
        35                  40                  45              


Asn Glu Gly Ser Val Thr Gly Ser Cys Tyr Cys Gly Lys Arg Ile Ser 
    50                  55                  60                  


Ser Asp Ser Pro Pro Ser Val Gln Phe Met Asn Arg Leu Arg Lys His 
65                  70                  75                  80  


Leu Arg Ala Tyr His Arg Cys Leu Tyr Tyr Thr Arg Phe Gln Leu Leu 
                85                  90                  95      


Ser Trp Ser Val Cys Gly Gly Asn Lys Asp Pro Trp Val Gln Glu Leu 
            100                 105                 110         


Met Ser Cys Leu Asp Leu Lys Glu Cys Gly His Ala Tyr Ser Gly Ile 
        115                 120                 125             


Val Ala His Gln Lys His Leu Leu Pro Thr Ser Pro Pro Ile Ser Gln 
    130                 135                 140                 


Ala Ser Glu Gly Ala Ser Ser Asp Ile His Thr Pro Ala Gln Met Leu 
145                 150                 155                 160 


Leu Ser Thr Leu Gln Ser Thr Gln Arg Pro Thr Leu Pro Val Gly Ser 
                165                 170                 175     


Leu Ser Ser Asp Lys Glu Leu Thr Arg Pro Asn Glu Thr Thr Ile His 
            180                 185                 190         


Thr Ala Gly His Ser Leu Ala Ala Gly Pro Glu Ala Gly Glu Asn Gln 
        195                 200                 205             


Lys Gln Pro Glu Lys Asn Ala Gly Pro Thr Ala Arg Thr Ser Ala Thr 
    210                 215                 220                 


Val Pro Val Leu Cys Leu Leu Ala Ile Ile Phe Ile Leu Thr Ala Ala 
225                 230                 235                 240 


Leu Ser Tyr Val Leu Cys Lys Arg Arg Arg Gly Gln Ser Pro Gln Ser 
                245                 250                 255     


Ser Pro Asp Leu Pro Val His Tyr Ile Pro Val Ala Pro Asp Ser Asn 
            260                 265                 270         


Thr 
    


<210>  1194
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  1194

Met Ala Ala Asp Gly Glu Arg Ser Pro Leu Leu Ser Glu Pro Ile Asp 
1               5                   10                  15      


Gly Gly Ala Gly Gly Asn Gly Leu Val Gly Pro Gly Gly Ser Gly Ala 
            20                  25                  30          


Gly Pro Gly Gly Gly Leu Thr Pro Ser Ala Pro Pro Tyr Gly Ala Gly 
        35                  40                  45              


Lys His Ala Pro Pro Gln Ala Phe Pro Pro Phe Pro Glu Gly His Pro 
    50                  55                  60                  


Ala Val Leu Pro Gly Glu Asp Pro Pro Pro Tyr Ser Pro Leu Thr Ser 
65                  70                  75                  80  


Pro Asp Ser Gly Ser Ala Pro Met Ile Thr Cys Arg Val Cys Gln Ser 
                85                  90                  95      


Leu Ile Asn Val Glu Gly Lys Met His Gln His Val Val Lys Cys Gly 
            100                 105                 110         


Val Cys Asn Glu Ala Thr Pro Ile Lys Asn Ala Pro Pro Gly Lys Lys 
        115                 120                 125             


Tyr Val Arg Cys Pro Cys Asn Cys Leu Leu Ile Cys Lys Val Thr Ser 
    130                 135                 140                 


Gln Arg Ile Ala Cys Pro Arg Pro Tyr Cys Lys Arg Ile Ile Asn Leu 
145                 150                 155                 160 


Gly Pro Val His Pro Gly Pro Leu Ser Pro Glu Pro Gln Pro Met Gly 
                165                 170                 175     


Val Arg Val Ile Cys Gly His Cys Lys Asn Thr Phe Leu Trp Thr Glu 
            180                 185                 190         


Phe Thr Asp Arg Thr Leu Ala Arg Cys Pro His Cys Arg Lys Val Ser 
        195                 200                 205             


Ser Ile Gly Arg Arg Tyr Pro Arg Lys Arg Cys Ile Cys Cys Phe Leu 
    210                 215                 220                 


Leu Gly Leu Leu Leu Ala Val Thr Ala Thr Gly Leu Ala Phe Gly Thr 
225                 230                 235                 240 


Trp Lys His Ala Arg Arg Tyr Gly Gly Ile Tyr Ala Ala Trp Ala Phe 
                245                 250                 255     


Val Ile Leu Leu Ala Val Leu Cys Leu Gly Arg Ala Leu Tyr Trp Ala 
            260                 265                 270         


Cys Met Lys Val Ser His Pro Val Gln Asn Phe Ser 
        275                 280                 


<210>  1195
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  1195

Met Lys Ala Glu Gly Gly Asp His Ser Met Ile Asn Leu Ser Val Gln 
1               5                   10                  15      


Gln Val Leu Ser Leu Trp Ala His Gly Thr Val Leu Arg Asn Leu Thr 
            20                  25                  30          


Glu Met Trp Tyr Trp Ile Phe Leu Trp Ala Leu Phe Ser Ser Leu Phe 
        35                  40                  45              


Val His Gly Ala Ala Gly Val Leu Met Phe Val Met Leu Gln Arg His 
    50                  55                  60                  


Arg Gln Gly Arg Val Ile Ser Val Ile Ala Val Ser Ile Gly Phe Leu 
65                  70                  75                  80  


Ala Ser Val Thr Gly Ala Met Ile Thr Ser Ala Ala Val Ala Gly Ile 
                85                  90                  95      


Tyr Arg Val Ala Gly Lys Asn Met Ala Pro Leu Glu Ala Leu Val Trp 
            100                 105                 110         


Gly Val Gly Gln Thr Val Leu Thr Leu Ile Ile Ser Phe Ser Arg Ile 
        115                 120                 125             


Leu Ala Thr Leu 
    130         


<210>  1196
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  1196

Met His Thr Thr Glu Ser Lys Asn Glu His Leu Glu Asp Glu Asn Phe 
1               5                   10                  15      


Gln Thr Ser Thr Thr Pro Gln Ser Leu Ile Asp Pro Asn Asn Thr Ala 
            20                  25                  30          


His Glu Glu Thr Lys Thr Val Leu Ser Asp Thr Glu Glu Ile Lys Pro 
        35                  40                  45              


Gln Thr Lys Lys Glu Thr Tyr Ile Ser Cys Pro Leu Arg Gly Val Leu 
    50                  55                  60                  


Asn Val Ile Ile Thr Asn Gly Val Ile Leu Phe Val Ile Trp Cys Met 
65                  70                  75                  80  


Thr Trp Ser Ile Leu Gly Ser Glu Ala Leu Pro Gly Gly Asn Leu Phe 
                85                  90                  95      


Gly Leu Phe Ile Ile Phe Tyr Ser Ala Ile Ile Gly Gly Lys Ile Leu 
            100                 105                 110         


Gln Leu Ile Arg Ile Pro Leu Val Pro Pro Leu Pro Pro Leu Leu Gly 
        115                 120                 125             


Met Leu Leu Ala Gly Phe Thr Ile Arg Asn Val Pro Phe Ile Asn Glu 
    130                 135                 140                 


His Val His Val Pro Asn Thr Trp Ser Ser Ile Leu Arg Ser Ile Ala 
145                 150                 155                 160 


Leu Thr Ile Ile Leu Ile Arg Ala Gly Leu Gly Leu Asp Pro Gln Ala 
                165                 170                 175     


Leu Arg His Leu Lys Val Val Cys Phe Arg Leu Ala Val Gly Pro Cys 
            180                 185                 190         


Leu Met Glu Ala Ser Ala Ala Ala Val Phe Ser His Phe Ile Met Lys 
        195                 200                 205             


Phe Pro Trp Gln Trp Ala Phe Leu Leu Gly Phe Val Leu Gly Ala Val 
    210                 215                 220                 


Ser Pro Ala Val Val Val Pro Tyr Met Met Val Leu Gln Glu Asn Gly 
225                 230                 235                 240 


Tyr Gly Val Glu Glu Gly Ile Pro Thr Leu Leu Met Ala Ala Ser Ser 
                245                 250                 255     


Met Asp Asp Ile Leu Ala Ile Thr Gly Phe Asn Thr Cys Leu Ser Ile 
            260                 265                 270         


Val Phe Ser Ser Gly Gly Ile Leu Asn Asn Ala Ile Ala Ser Ile Arg 
        275                 280                 285             


Asn Val Cys Ile Ser Leu Leu Ala Gly Ile Val Leu Gly Phe Phe Val 
    290                 295                 300                 


Arg Tyr Phe Pro Ser Glu Asp Gln Lys Lys Leu Thr Leu Lys Arg Gly 
305                 310                 315                 320 


Phe Leu Val Leu Thr Met Cys Val Ser Ala Val Leu Gly Ser Gln Arg 
                325                 330                 335     


Ile Gly Leu His Gly Ser Gly Gly Leu Cys Thr Leu Val Leu Ser Phe 
            340                 345                 350         


Ile Ala Gly Thr Lys Trp Ser Gln Glu Lys Met Lys Val Gln Lys Ile 
        355                 360                 365             


Ile Thr Thr Val Trp Asp Ile Phe Gln Pro Leu Leu Phe Gly Leu Val 
    370                 375                 380                 


Gly Ala Glu Val Ser Val Ser Ser Leu Glu Ser Asn Ile Val Gly Ile 
385                 390                 395                 400 


Ser Val Ala Thr Leu Ser Leu Ala Leu Cys Val Arg Ile Leu Thr Thr 
                405                 410                 415     


Tyr Leu Leu Met Cys Phe Ala Gly Phe Ser Phe Lys Glu Lys Ile Phe 
            420                 425                 430         


Ile Ala Leu Ala Trp Met Pro Lys Ala Thr Val Gln Ile Asn Gln Ala 
        435                 440                 445             


Ile Leu Leu Leu Phe Leu Leu Arg Glu Glu Trp Thr Asn Cys Lys Val 
    450                 455                 460                 


Ala Lys Lys Cys Glu Tyr Thr Lys Glu Arg Gln 
465                 470                 475 


<210>  1197
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  1197

Met Thr Gln Asn Thr Val Ile Val Asn Gly Val Ala Met Ala Ser Arg 
1               5                   10                  15      


Pro Ser Gln Pro Thr His Val Asn Val His Ile His Gln Glu Ser Ala 
            20                  25                  30          


Leu Thr Gln Leu Leu Lys Ala Gly Gly Ser Leu Lys Lys Phe Leu Phe 
        35                  40                  45              


His Pro Gly Asp Thr Val Pro Ser Thr Ala Arg Ile Gly Tyr Glu Gln 
    50                  55                  60                  


Leu Ala Leu Gly Val Thr Gln Ile Leu Leu Gly Val Val Ser Cys Val 
65                  70                  75                  80  


Leu Gly Val Cys Leu Ser Leu Gly Pro Trp Thr Val Leu Ser Ala Ser 
                85                  90                  95      


Gly Cys Ala Phe Trp Ala Gly Ser Val Val Ile Ala Ala Gly Ala Gly 
            100                 105                 110         


Ala Ile Val His Glu Lys His Pro Gly Lys Leu Ala Gly Tyr Ile Ser 
        115                 120                 125             


Ser Leu Leu Thr Leu Ala Gly Phe Ala Thr Ala Met Ala Ala Val Val 
    130                 135                 140                 


Leu Cys Val Asn Ser Phe Ile Trp Gln Thr Glu Pro Phe Leu Tyr Ile 
145                 150                 155                 160 


Asp Thr Val Cys Asp Arg Ser Asp Pro Val Phe Pro Thr Thr Gly Tyr 
                165                 170                 175     


Arg Trp Met Arg Arg Ser Gln Glu Asn Gln Trp Gln Lys Glu Glu Cys 
            180                 185                 190         


Arg Ala Tyr Met Gln Met Leu Arg Lys Leu Phe Thr Ala Ile Arg Ala 
        195                 200                 205             


Leu Phe Leu Ala Val Cys Val Leu Lys Val Ile Val Ser Leu Val Ser 
    210                 215                 220                 


Leu Gly Val Gly Leu Arg Asn Leu Cys Gly Gln Ser Ser Gln Pro Leu 
225                 230                 235                 240 


Asn Glu Glu Gly Ser Glu Lys Arg Leu Leu Gly Glu Asn Ser Val Pro 
                245                 250                 255     


Pro Ser Pro Ser Arg Glu Gln Thr Ser Thr Ala Ile Val Leu 
            260                 265                 270 


<210>  1198
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  1198

Met Thr Gln Asn Thr Val Ile Val Asn Gly Val Ala Met Ala Ser Arg 
1               5                   10                  15      


Pro Ser Gln Pro Thr His Val Asn Val His Ile His Gln Glu Ser Ala 
            20                  25                  30          


Leu Thr Gln Leu Leu Lys Ala Gly Gly Ser Leu Lys Lys Phe Leu Phe 
        35                  40                  45              


His Pro Gly Asp Thr Val Pro Ser Thr Ala Arg Ile Gly Tyr Glu Gln 
    50                  55                  60                  


Leu Ala Leu Gly Val Thr Gln Ile Leu Leu Gly Val Val Ser Cys Val 
65                  70                  75                  80  


Leu Gly Val Cys Leu Ser Leu Gly Pro Trp Thr Val Leu Ser Ala Ser 
                85                  90                  95      


Gly Cys Ala Phe Trp Ala Gly Ser Val Val Ile Ala Ala Gly Ala Gly 
            100                 105                 110         


Ala Ile Val His Glu Lys His Pro Gly Lys Leu Ala Gly Tyr Ile Ser 
        115                 120                 125             


Ser Leu Leu Thr Leu Ala Gly Phe Ala Thr Ala Met Ala Ala Val Val 
    130                 135                 140                 


Leu Cys Val Asn Ser Phe Ile Trp Gln Thr Glu Pro Phe Leu Tyr Ile 
145                 150                 155                 160 


Asp Thr Val Cys Asp Arg Ser Asp Pro Val Phe Pro Thr Thr Gly Tyr 
                165                 170                 175     


Arg Trp Met Arg Arg Ser Gln Glu Asn Gln Trp Gln Lys Glu Glu Cys 
            180                 185                 190         


Arg Ala Tyr Met Gln Met Leu Arg Lys Leu Phe Thr Ala Ile Arg Ala 
        195                 200                 205             


Leu Phe Leu Ala Val Cys Val Leu Lys Val Ile Val Ser Leu Val Ser 
    210                 215                 220                 


Leu Gly Val Gly Leu Arg Asn Leu Cys Gly Gln Ser Ser Gln Pro Leu 
225                 230                 235                 240 


Asn Glu Glu Gly Ser Glu Lys Arg Leu Leu Gly Glu Asn Ser Val Pro 
                245                 250                 255     


Pro Ser Pro Ser Arg Glu Gln Thr Ser Thr Ala Ile Val Leu 
            260                 265                 270 


<210>  1199
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  1199

Met Thr Gln Asn Thr Val Ile Val Asn Gly Val Ala Met Ala Ser Arg 
1               5                   10                  15      


Pro Ser Gln Pro Thr His Val Asn Val His Ile His Gln Glu Ser Ala 
            20                  25                  30          


Leu Thr Gln Leu Leu Lys Ala Gly Gly Ser Leu Lys Lys Phe Leu Phe 
        35                  40                  45              


His Pro Gly Asp Thr Val Pro Ser Thr Ala Arg Ile Gly Tyr Glu Gln 
    50                  55                  60                  


Leu Ala Leu Gly Val Thr Gln Ile Leu Leu Gly Val Val Ser Cys Val 
65                  70                  75                  80  


Leu Gly Val Cys Leu Ser Leu Gly Pro Trp Thr Val Leu Ser Ala Ser 
                85                  90                  95      


Gly Cys Ala Phe Trp Ala Gly Ser Val Val Ile Ala Ala Gly Ala Gly 
            100                 105                 110         


Ala Ile Val His Glu Lys His Pro Gly Lys Leu Ala Gly Tyr Ile Ser 
        115                 120                 125             


Ser Leu Leu Thr Leu Ala Gly Phe Ala Thr Ala Met Ala Ala Val Val 
    130                 135                 140                 


Leu Cys Val Asn Ser Phe Ile Trp Gln Thr Glu Pro Phe Leu Tyr Ile 
145                 150                 155                 160 


Asp Thr Val Cys Asp Arg Ser Asp Pro Val Phe Pro Thr Thr Gly Tyr 
                165                 170                 175     


Arg Trp Met Arg Arg Ser Gln Glu Asn Gln Trp Gln Lys Glu Glu Cys 
            180                 185                 190         


Arg Ala Tyr Met Gln Met Leu Arg Lys Leu Phe Thr Ala Ile Arg Ala 
        195                 200                 205             


Leu Phe Leu Ala Val Cys Val Leu Lys Val Ile Val Ser Leu Val Ser 
    210                 215                 220                 


Leu Gly Val Gly Leu Arg Asn Leu Cys Gly Gln Ser Ser Gln Pro Leu 
225                 230                 235                 240 


Asn Glu Glu Gly Ser Glu Lys Arg Leu Leu Gly Glu Asn Ser Val Pro 
                245                 250                 255     


Pro Ser Pro Ser Arg Glu Gln Thr Ser Thr Ala Ile Val Leu 
            260                 265                 270 


<210>  1200
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  1200

Met Thr Gln Asn Thr Val Ile Val Asn Gly Val Ala Met Ala Ser Arg 
1               5                   10                  15      


Pro Ser Gln Pro Thr His Val Asn Val His Ile His Gln Glu Ser Ala 
            20                  25                  30          


Leu Thr Gln Leu Leu Lys Ala Gly Gly Ser Leu Lys Lys Phe Leu Phe 
        35                  40                  45              


His Pro Gly Asp Thr Val Pro Ser Thr Ala Arg Ile Gly Tyr Glu Gln 
    50                  55                  60                  


Leu Ala Leu Gly Val Ile Ala Ala Gly Ala Gly Ala Ile Val His Glu 
65                  70                  75                  80  


Lys His Pro Gly Lys Leu Ala Gly Tyr Ile Ser Ser Leu Leu Thr Leu 
                85                  90                  95      


Ala Gly Phe Ala Thr Ala Met Ala Ala Val Val Leu Cys Val Asn Ser 
            100                 105                 110         


Phe Ile Trp Gln Thr Glu Pro Phe Leu Tyr Ile Asp Thr Val Cys Asp 
        115                 120                 125             


Arg Ser Asp Pro Val Phe Pro Thr Thr Gly Tyr Arg Trp Met Arg Arg 
    130                 135                 140                 


Ser Gln Glu Asn Gln Trp Gln Lys Glu Glu Cys Arg Ala Tyr Met Gln 
145                 150                 155                 160 


Met Leu Arg Lys Leu Phe Thr Ala Ile Arg Ala Leu Phe Leu Ala Val 
                165                 170                 175     


Cys Val Leu Lys Val Ile Val Ser Leu Val Ser Leu Gly Val Gly Leu 
            180                 185                 190         


Arg Asn Leu Cys Gly Gln Ser Ser Gln Pro Leu Asn Glu Glu Gly Ser 
        195                 200                 205             


Glu Lys Arg Leu Leu Gly Glu Asn Ser Val Pro Pro Ser Pro Ser Arg 
    210                 215                 220                 


Glu Gln Thr Ser Thr Ala Ile Val Leu 
225                 230             


<210>  1201
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  1201

Met Thr Met Glu Thr Leu Pro Lys Val Leu Glu Val Asp Glu Lys Ser 
1               5                   10                  15      


Pro Glu Ala Lys Asp Leu Leu Pro Ser Gln Thr Ala Ser Ser Leu Cys 
            20                  25                  30          


Ile Ser Ser Arg Ser Glu Ser Val Trp Thr Thr Thr Pro Arg Ser Asn 
        35                  40                  45              


Trp Glu Ile Tyr Arg Lys Pro Ile Val Ile Met Ser Val Gly Gly Ala 
    50                  55                  60                  


Ile Leu Leu Phe Gly Val Val Ile Thr Cys Leu Ala Tyr Thr Leu Lys 
65                  70                  75                  80  


Leu Ser Asp Lys Ser Leu Ser Ile Leu Lys Met Val Gly Pro Gly Phe 
                85                  90                  95      


Leu Ser Leu Gly Leu Met Met Leu Val Cys Gly Leu Val Trp Val Pro 
            100                 105                 110         


Ile Ile Lys Lys Lys Gln Lys His Arg Gln Lys Ser Asn Phe Leu Arg 
        115                 120                 125             


Ser Leu Lys Ser Phe Phe Leu Thr Arg 
    130                 135         


<210>  1202
<211>  592
<212>  PRT
<213>  Homo sapiens

<400>  1202

Met Thr Cys Trp Leu Cys Val Leu Ser Leu Pro Leu Leu Leu Leu Pro 
1               5                   10                  15      


Ala Ala Pro Pro Pro Ala Gly Gly Cys Pro Ala Arg Cys Glu Cys Thr 
            20                  25                  30          


Val Gln Thr Arg Ala Val Ala Cys Thr Arg Arg Arg Leu Thr Ala Val 
        35                  40                  45              


Pro Asp Gly Ile Pro Ala Glu Thr Arg Leu Leu Glu Leu Ser Arg Asn 
    50                  55                  60                  


Arg Ile Arg Cys Leu Asn Pro Gly Asp Leu Ala Ala Leu Pro Ala Leu 
65                  70                  75                  80  


Glu Glu Leu Asp Leu Ser Glu Asn Ala Ile Ala His Val Glu Pro Gly 
                85                  90                  95      


Ala Phe Ala Asn Leu Pro Arg Leu Arg Val Leu Arg Leu Arg Gly Asn 
            100                 105                 110         


Gln Leu Lys Leu Ile Pro Pro Gly Val Phe Thr Arg Leu Asp Asn Leu 
        115                 120                 125             


Thr Leu Leu Asp Leu Ser Glu Asn Lys Leu Val Ile Leu Leu Asp Tyr 
    130                 135                 140                 


Thr Phe Gln Asp Leu His Ser Leu Arg Arg Leu Glu Val Gly Asp Asn 
145                 150                 155                 160 


Asp Leu Val Phe Val Ser Arg Arg Ala Phe Ala Gly Leu Leu Ala Leu 
                165                 170                 175     


Glu Glu Leu Thr Leu Glu Arg Cys Asn Leu Thr Ala Leu Ser Gly Glu 
            180                 185                 190         


Ser Leu Gly His Leu Arg Ser Leu Gly Ala Leu Arg Leu Arg His Leu 
        195                 200                 205             


Ala Ile Ala Ser Leu Glu Asp Gln Asn Phe Arg Arg Leu Pro Gly Leu 
    210                 215                 220                 


Leu His Leu Glu Ile Asp Asn Trp Pro Leu Leu Glu Glu Val Ala Ala 
225                 230                 235                 240 


Gly Ser Leu Arg Gly Leu Asn Leu Thr Ser Leu Ser Val Thr His Thr 
                245                 250                 255     


Asn Ile Thr Ala Val Pro Ala Ala Ala Leu Arg His Gln Ala His Leu 
            260                 265                 270         


Thr Cys Leu Asn Leu Ser His Asn Pro Ile Ser Thr Val Pro Arg Gly 
        275                 280                 285             


Ser Phe Arg Asp Leu Val Arg Leu Arg Glu Leu His Leu Ala Gly Ala 
    290                 295                 300                 


Leu Leu Ala Val Val Glu Pro Gln Ala Phe Leu Gly Leu Arg Gln Ile 
305                 310                 315                 320 


Arg Leu Leu Asn Leu Ser Asn Asn Leu Leu Ser Thr Leu Glu Glu Ser 
                325                 330                 335     


Thr Phe His Ser Val Asn Thr Leu Glu Thr Leu Arg Val Asp Gly Asn 
            340                 345                 350         


Pro Leu Ala Cys Asp Cys Arg Leu Leu Trp Ile Val Gln Arg Arg Lys 
        355                 360                 365             


Thr Leu Asn Phe Asp Gly Arg Leu Pro Ala Cys Ala Thr Pro Ala Glu 
    370                 375                 380                 


Val Arg Gly Asp Ala Leu Arg Asn Leu Pro Asp Ser Val Leu Phe Glu 
385                 390                 395                 400 


Tyr Phe Val Cys Arg Lys Pro Lys Ile Arg Glu Arg Arg Leu Gln Arg 
                405                 410                 415     


Val Thr Ala Thr Ala Gly Glu Asp Val Arg Phe Leu Cys Arg Ala Glu 
            420                 425                 430         


Gly Glu Pro Ala Pro Thr Val Ala Trp Val Thr Pro Gln His Arg Pro 
        435                 440                 445             


Val Thr Ala Thr Ser Ala Gly Arg Ala Arg Val Leu Pro Gly Gly Thr 
    450                 455                 460                 


Leu Glu Ile Gln Asp Ala Arg Pro Gln Asp Ser Gly Thr Tyr Thr Cys 
465                 470                 475                 480 


Val Ala Ser Asn Ala Gly Gly Asn Asp Thr Tyr Phe Ala Thr Leu Thr 
                485                 490                 495     


Val Arg Pro Glu Pro Ala Ala Asn Arg Thr Pro Gly Glu Ala His Asn 
            500                 505                 510         


Glu Thr Leu Ala Ala Leu Arg Ala Pro Leu Asp Leu Thr Thr Ile Leu 
        515                 520                 525             


Val Ser Thr Ala Met Gly Cys Ile Thr Phe Leu Gly Val Val Leu Phe 
    530                 535                 540                 


Cys Phe Val Leu Leu Phe Val Trp Ser Arg Gly Arg Gly Gln His Lys 
545                 550                 555                 560 


Asn Asn Phe Ser Val Glu Tyr Ser Phe Arg Lys Val Asp Gly Pro Ala 
                565                 570                 575     


Ala Ala Ala Gly Gln Gly Gly Ala Arg Lys Phe Asn Met Lys Met Ile 
            580                 585                 590         


<210>  1203
<211>  1332
<212>  PRT
<213>  Homo sapiens

<400>  1203

Met Ala Glu Ala Gly Leu Arg Gly Trp Leu Leu Trp Ala Leu Leu Leu 
1               5                   10                  15      


Arg Leu Ala Gln Ser Glu Pro Tyr Thr Thr Ile His Gln Pro Gly Tyr 
            20                  25                  30          


Cys Ala Phe Tyr Asp Glu Cys Gly Lys Asn Pro Glu Leu Ser Gly Ser 
        35                  40                  45              


Leu Met Thr Leu Ser Asn Val Ser Cys Leu Ser Asn Thr Pro Ala Arg 
    50                  55                  60                  


Lys Ile Thr Gly Asp His Leu Ile Leu Leu Gln Lys Ile Cys Pro Arg 
65                  70                  75                  80  


Leu Tyr Thr Gly Pro Asn Thr Gln Ala Cys Cys Ser Ala Lys Gln Leu 
                85                  90                  95      


Val Ser Leu Glu Ala Ser Leu Ser Ile Thr Lys Ala Leu Leu Thr Arg 
            100                 105                 110         


Cys Pro Ala Cys Ser Asp Asn Phe Val Asn Leu His Cys His Asn Thr 
        115                 120                 125             


Cys Ser Pro Asn Gln Ser Leu Phe Ile Asn Val Thr Arg Val Ala Gln 
    130                 135                 140                 


Leu Gly Ala Gly Gln Leu Pro Ala Val Val Ala Tyr Glu Ala Phe Tyr 
145                 150                 155                 160 


Gln His Ser Phe Ala Glu Gln Ser Tyr Asp Ser Cys Ser Arg Val Arg 
                165                 170                 175     


Val Pro Ala Ala Ala Thr Leu Ala Val Gly Thr Met Cys Gly Val Tyr 
            180                 185                 190         


Gly Ser Ala Leu Cys Asn Ala Gln Arg Trp Leu Asn Phe Gln Gly Asp 
        195                 200                 205             


Thr Gly Asn Gly Leu Ala Pro Leu Asp Ile Thr Phe His Leu Leu Glu 
    210                 215                 220                 


Pro Gly Gln Ala Val Gly Ser Gly Ile Gln Pro Leu Asn Glu Gly Val 
225                 230                 235                 240 


Ala Arg Cys Asn Glu Ser Gln Gly Asp Asp Val Ala Thr Cys Ser Cys 
                245                 250                 255     


Gln Asp Cys Ala Ala Ser Cys Pro Ala Ile Ala Arg Pro Gln Ala Leu 
            260                 265                 270         


Asp Ser Thr Phe Tyr Leu Gly Gln Met Pro Gly Ser Leu Val Leu Ile 
        275                 280                 285             


Ile Ile Leu Cys Ser Val Phe Ala Val Val Thr Ile Leu Leu Val Gly 
    290                 295                 300                 


Phe Arg Val Ala Pro Ala Arg Asp Lys Ser Lys Met Val Asp Pro Lys 
305                 310                 315                 320 


Lys Gly Thr Ser Leu Ser Asp Lys Leu Ser Phe Ser Thr His Thr Leu 
                325                 330                 335     


Leu Gly Gln Phe Phe Gln Gly Trp Gly Thr Trp Val Ala Ser Trp Pro 
            340                 345                 350         


Leu Thr Ile Leu Val Leu Ser Val Ile Pro Val Val Ala Leu Ala Ala 
        355                 360                 365             


Gly Leu Val Phe Thr Glu Leu Thr Thr Asp Pro Val Glu Leu Trp Ser 
    370                 375                 380                 


Ala Pro Asn Ser Gln Ala Arg Ser Glu Lys Ala Phe His Asp Gln His 
385                 390                 395                 400 


Phe Gly Pro Phe Phe Arg Thr Asn Gln Val Ile Leu Thr Ala Pro Asn 
                405                 410                 415     


Arg Ser Ser Tyr Arg Tyr Asp Ser Leu Leu Leu Gly Pro Lys Asn Phe 
            420                 425                 430         


Ser Gly Ile Leu Asp Leu Asp Leu Leu Leu Glu Leu Leu Glu Leu Gln 
        435                 440                 445             


Glu Arg Leu Arg His Leu Gln Val Trp Ser Pro Glu Ala Gln Arg Asn 
    450                 455                 460                 


Ile Ser Leu Gln Asp Ile Cys Tyr Ala Pro Leu Asn Pro Asp Asn Thr 
465                 470                 475                 480 


Ser Leu Tyr Asp Cys Cys Ile Asn Ser Leu Leu Gln Tyr Phe Gln Asn 
                485                 490                 495     


Asn Arg Thr Leu Leu Leu Leu Thr Ala Asn Gln Thr Leu Met Gly Gln 
            500                 505                 510         


Thr Ser Gln Val Asp Trp Lys Asp His Phe Leu Tyr Cys Ala Asn Ala 
        515                 520                 525             


Pro Leu Thr Phe Lys Asp Gly Thr Ala Leu Ala Leu Ser Cys Met Ala 
    530                 535                 540                 


Asp Tyr Gly Ala Pro Val Phe Pro Phe Leu Ala Ile Gly Gly Tyr Lys 
545                 550                 555                 560 


Gly Lys Asp Tyr Ser Glu Ala Glu Ala Leu Ile Met Thr Phe Ser Leu 
                565                 570                 575     


Asn Asn Tyr Pro Ala Gly Asp Pro Arg Leu Ala Gln Ala Lys Leu Trp 
            580                 585                 590         


Glu Glu Ala Phe Leu Glu Glu Met Arg Ala Phe Gln Arg Arg Met Ala 
        595                 600                 605             


Gly Met Phe Gln Val Thr Phe Met Ala Glu Arg Ser Leu Glu Asp Glu 
    610                 615                 620                 


Ile Asn Arg Thr Thr Ala Glu Asp Leu Pro Ile Phe Ala Thr Ser Tyr 
625                 630                 635                 640 


Ile Val Ile Phe Leu Tyr Ile Ser Leu Ala Leu Gly Ser Tyr Ser Ser 
                645                 650                 655     


Trp Ser Arg Val Met Val Asp Ser Lys Ala Thr Leu Gly Leu Gly Gly 
            660                 665                 670         


Val Ala Val Val Leu Gly Ala Val Met Ala Ala Met Gly Phe Phe Ser 
        675                 680                 685             


Tyr Leu Gly Ile Arg Ser Ser Leu Val Ile Leu Gln Val Val Pro Phe 
    690                 695                 700                 


Leu Val Leu Ser Val Gly Ala Asp Asn Ile Phe Ile Phe Val Leu Glu 
705                 710                 715                 720 


Tyr Gln Arg Leu Pro Arg Arg Pro Gly Glu Pro Arg Glu Val His Ile 
                725                 730                 735     


Gly Arg Ala Leu Gly Arg Val Ala Pro Ser Met Leu Leu Cys Ser Leu 
            740                 745                 750         


Ser Glu Ala Ile Cys Phe Phe Leu Gly Ala Leu Thr Pro Met Pro Ala 
        755                 760                 765             


Val Arg Thr Phe Ala Leu Thr Ser Gly Leu Ala Val Ile Leu Asp Phe 
    770                 775                 780                 


Leu Leu Gln Met Ser Ala Phe Val Ala Leu Leu Ser Leu Asp Ser Lys 
785                 790                 795                 800 


Arg Gln Glu Ala Ser Arg Leu Asp Val Cys Cys Cys Val Lys Pro Gln 
                805                 810                 815     


Glu Leu Pro Pro Pro Gly Gln Gly Glu Gly Leu Leu Leu Gly Phe Phe 
            820                 825                 830         


Gln Lys Ala Tyr Ala Pro Phe Leu Leu His Trp Ile Thr Arg Gly Val 
        835                 840                 845             


Val Leu Leu Leu Phe Leu Ala Leu Phe Gly Val Ser Leu Tyr Ser Met 
    850                 855                 860                 


Cys His Ile Ser Val Gly Leu Asp Gln Glu Leu Ala Leu Pro Lys Asp 
865                 870                 875                 880 


Ser Tyr Leu Leu Asp Tyr Phe Leu Phe Leu Asn Arg Tyr Phe Glu Val 
                885                 890                 895     


Gly Ala Pro Val Tyr Phe Val Thr Thr Leu Gly Tyr Asn Phe Ser Ser 
            900                 905                 910         


Glu Ala Gly Met Asn Ala Ile Cys Ser Ser Ala Gly Cys Asn Asn Phe 
        915                 920                 925             


Ser Phe Thr Gln Lys Ile Gln Tyr Ala Thr Glu Phe Pro Glu Gln Ser 
    930                 935                 940                 


Tyr Leu Ala Ile Pro Ala Ser Ser Trp Val Asp Asp Phe Ile Asp Trp 
945                 950                 955                 960 


Leu Thr Pro Ser Ser Cys Cys Arg Leu Tyr Ile Ser Gly Pro Asn Lys 
                965                 970                 975     


Asp Lys Phe Cys Pro Ser Thr Val Asn Ser Leu Asn Cys Leu Lys Asn 
            980                 985                 990         


Cys Met Ser Ile Thr Met Gly Ser  Val Arg Pro Ser Val  Glu Gln Phe 
        995                 1000                 1005             


His Lys  Tyr Leu Pro Trp Phe  Leu Asn Asp Arg Pro  Asn Ile Lys 
    1010                 1015                 1020             


Cys Pro  Lys Gly Gly Leu Ala  Ala Tyr Ser Thr Ser  Val Asn Leu 
    1025                 1030                 1035             


Thr Ser  Asp Gly Gln Val Leu  Ala Ser Arg Phe Met  Ala Tyr His 
    1040                 1045                 1050             


Lys Pro  Leu Lys Asn Ser Gln  Asp Tyr Thr Glu Ala  Leu Arg Ala 
    1055                 1060                 1065             


Ala Arg  Glu Leu Ala Ala Asn  Ile Thr Ala Asp Leu  Arg Lys Val 
    1070                 1075                 1080             


Pro Gly  Thr Asp Pro Ala Phe  Glu Val Phe Pro Tyr  Thr Ile Thr 
    1085                 1090                 1095             


Asn Val  Phe Tyr Glu Gln Tyr  Leu Thr Ile Leu Pro  Glu Gly Leu 
    1100                 1105                 1110             


Phe Met  Leu Ser Leu Cys Leu  Val Pro Thr Phe Ala  Val Ser Cys 
    1115                 1120                 1125             


Leu Leu  Leu Gly Leu Asp Leu  Arg Ser Gly Leu Leu  Asn Leu Leu 
    1130                 1135                 1140             


Ser Ile  Val Met Ile Leu Val  Asp Thr Val Gly Phe  Met Ala Leu 
    1145                 1150                 1155             


Trp Gly  Ile Ser Tyr Asn Ala  Val Ser Leu Ile Asn  Leu Val Ser 
    1160                 1165                 1170             


Ala Val  Gly Met Ser Val Glu  Phe Val Ser His Ile  Thr Arg Ser 
    1175                 1180                 1185             


Phe Ala  Ile Ser Thr Lys Pro  Thr Trp Leu Glu Arg  Ala Lys Glu 
    1190                 1195                 1200             


Ala Thr  Ile Ser Met Gly Ser  Ala Val Phe Ala Gly  Val Ala Met 
    1205                 1210                 1215             


Thr Asn  Leu Pro Gly Ile Leu  Val Leu Gly Leu Ala  Lys Ala Gln 
    1220                 1225                 1230             


Leu Ile  Gln Ile Phe Phe Phe  Arg Leu Asn Leu Leu  Ile Thr Leu 
    1235                 1240                 1245             


Leu Gly  Leu Leu His Gly Leu  Val Phe Leu Pro Val  Ile Leu Ser 
    1250                 1255                 1260             


Tyr Val  Gly Pro Asp Val Asn  Pro Ala Leu Ala Leu  Glu Gln Lys 
    1265                 1270                 1275             


Arg Ala  Glu Glu Ala Val Ala  Ala Val Met Val Ala  Ser Cys Pro 
    1280                 1285                 1290             


Asn His  Pro Ser Arg Val Ser  Thr Ala Asp Asn Ile  Tyr Val Asn 
    1295                 1300                 1305             


His Ser  Phe Glu Gly Ser Ile  Lys Gly Ala Gly Ala  Ile Ser Asn 
    1310                 1315                 1320             


Phe Leu  Pro Asn Asn Gly Arg  Gln Phe 
    1325                 1330         


<210>  1204
<211>  924
<212>  PRT
<213>  Homo sapiens

<400>  1204

Met Glu Ile Lys Glu Glu Gly Ala Ser Glu Glu Gly Gln His Phe Leu 
1               5                   10                  15      


Pro Thr Ala Gln Ala Asn Asp Pro Gly Asp Cys Gln Phe Thr Ser Ile 
            20                  25                  30          


Gln Lys Thr Pro Asn Glu Pro Gln Leu Glu Phe Ile Leu Ala Cys Lys 
        35                  40                  45              


Asp Leu Val Ala Pro Val Arg Asp Arg Lys Leu Asn Thr Leu Val Gln 
    50                  55                  60                  


Ile Ser Val Ile His Pro Val Glu Gln Ser Leu Thr Arg Tyr Ser Ser 
65                  70                  75                  80  


Thr Glu Ile Val Glu Gly Thr Arg Asp Pro Leu Phe Leu Thr Gly Val 
                85                  90                  95      


Thr Phe Pro Ser Glu Tyr Pro Ile Tyr Glu Glu Thr Lys Ile Lys Leu 
            100                 105                 110         


Thr Val Tyr Asp Val Lys Asp Lys Ser His Asp Thr Val Arg Thr Ser 
        115                 120                 125             


Val Leu Pro Glu His Lys Asp Pro Pro Pro Glu Val Gly Arg Ser Phe 
    130                 135                 140                 


Leu Gly Tyr Ala Ser Phe Lys Val Gly Glu Leu Leu Lys Ser Lys Glu 
145                 150                 155                 160 


Gln Leu Leu Val Leu Ser Leu Arg Thr Ser Asp Gly Gly Lys Val Val 
                165                 170                 175     


Gly Thr Ile Glu Val Ser Val Val Lys Met Gly Glu Ile Glu Asp Gly 
            180                 185                 190         


Glu Ala Asp His Ile Thr Thr Asp Val Gln Gly Gln Lys Cys Ala Leu 
        195                 200                 205             


Val Cys Glu Cys Thr Ala Pro Glu Ser Val Ser Gly Lys Asp Asn Leu 
    210                 215                 220                 


Pro Phe Leu Asn Ser Val Leu Lys Asn Pro Val Cys Lys Leu Tyr Arg 
225                 230                 235                 240 


Phe Pro Thr Ser Asp Asn Lys Trp Met Arg Ile Arg Glu Gln Met Ser 
                245                 250                 255     


Glu Ser Ile Leu Ser Phe His Ile Pro Lys Glu Leu Ile Ser Leu His 
            260                 265                 270         


Ile Lys Glu Asp Leu Cys Arg Asn Gln Glu Ile Lys Glu Leu Gly Glu 
        275                 280                 285             


Leu Ser Pro His Trp Asp Asn Leu Arg Lys Asn Val Leu Thr His Cys 
    290                 295                 300                 


Asp Gln Met Val Asn Met Tyr Gln Asp Ile Leu Thr Glu Leu Ser Lys 
305                 310                 315                 320 


Glu Thr Gly Ser Ser Phe Lys Ser Ser Ser Ser Lys Gly Glu Lys Thr 
                325                 330                 335     


Leu Glu Phe Val Pro Ile Asn Leu His Leu Gln Arg Met Gln Val His 
            340                 345                 350         


Ser Pro His Leu Lys Asp Ala Leu Tyr Asp Val Ile Thr Val Gly Ala 
        355                 360                 365             


Pro Ala Ala His Phe Gln Gly Phe Lys Asn Gly Gly Leu Arg Lys Leu 
    370                 375                 380                 


Leu His Arg Phe Glu Thr Glu Arg Arg Asn Thr Gly Tyr Gln Phe Ile 
385                 390                 395                 400 


Tyr Tyr Ser Pro Glu Asn Thr Ala Lys Ala Lys Glu Val Leu Ser Asn 
                405                 410                 415     


Ile Asn Gln Leu Gln Pro Leu Ile Ala Thr His Ala Asp Leu Leu Leu 
            420                 425                 430         


Asn Ser Ala Ser Gln His Ser Pro Asp Ser Leu Lys Asn Ser Leu Lys 
        435                 440                 445             


Met Leu Ser Glu Lys Thr Glu Leu Phe Val His Ala Phe Lys Asp Gln 
    450                 455                 460                 


Leu Val Arg Ser Ala Leu Leu Ala Leu Tyr Thr Ala Arg Pro Gly Gly 
465                 470                 475                 480 


Ile Leu Lys Lys Pro Pro Ser Pro Lys Ser Ser Thr Glu Glu Ser Ser 
                485                 490                 495     


Pro Gln Asp Gln Pro Pro Val Met Arg Gly Gln Asp Ser Ile Pro His 
            500                 505                 510         


His Ser Asp Tyr Asp Glu Glu Glu Trp Asp Arg Val Trp Ala Asn Val 
        515                 520                 525             


Gly Lys Ser Leu Asn Cys Ile Ile Ala Met Val Asp Lys Leu Ile Glu 
    530                 535                 540                 


Arg Asp Gly Gly Ser Glu Gly Ser Gly Gly Asn Asn Asp Gly Glu Lys 
545                 550                 555                 560 


Glu Pro Ser Leu Thr Asp Ala Ile Pro Ser His Pro Arg Glu Asp Trp 
                565                 570                 575     


Tyr Glu Gln Leu Tyr Pro Leu Ile Leu Thr Leu Lys Asp Cys Met Gly 
            580                 585                 590         


Glu Val Val Asn Arg Ala Lys Gln Ser Leu Thr Phe Val Leu Leu Gln 
        595                 600                 605             


Glu Leu Ala Tyr Ser Leu Pro Gln Cys Leu Met Leu Thr Leu Arg Arg 
    610                 615                 620                 


Asp Ile Val Phe Ser Gln Ala Leu Ala Gly Leu Val Cys Gly Phe Ile 
625                 630                 635                 640 


Ile Lys Leu Gln Thr Ser Leu Tyr Asp Pro Gly Phe Leu Gln Gln Leu 
                645                 650                 655     


His Thr Val Gly Leu Ile Val Gln Tyr Glu Gly Leu Leu Ser Thr Tyr 
            660                 665                 670         


Ser Asp Glu Ile Gly Met Leu Glu Asp Met Ala Val Gly Ile Ser Asp 
        675                 680                 685             


Leu Lys Lys Val Ala Phe Lys Ile Ile Glu Ala Lys Ser Asn Asp Val 
    690                 695                 700                 


Leu Pro Val Ile Thr Gly Arg Arg Glu His Tyr Val Val Glu Val Lys 
705                 710                 715                 720 


Leu Pro Ala Arg Met Phe Glu Ser Leu Pro Leu Gln Ile Lys Glu Gly 
                725                 730                 735     


Gln Leu Leu His Val Tyr Pro Val Leu Phe Asn Val Gly Ile Asn Glu 
            740                 745                 750         


Gln Gln Thr Leu Ala Glu Arg Phe Gly Asp Val Ser Leu Gln Glu Ser 
        755                 760                 765             


Ile Asn Gln Glu Asn Phe Glu Leu Leu Gln Glu Tyr Tyr Lys Ile Phe 
    770                 775                 780                 


Met Glu Lys Met Pro Pro Asp Tyr Ile Ser His Phe Gln Glu Gln Asn 
785                 790                 795                 800 


Asp Leu Lys Ala Leu Leu Glu Asn Leu Leu Gln Asn Ile Gln Ser Lys 
                805                 810                 815     


Lys Arg Lys Asn Val Glu Ile Met Trp Leu Ala Ala Thr Ile Cys Arg 
            820                 825                 830         


Lys Leu Asn Gly Ile Arg Phe Thr Cys Cys Lys Ser Ala Lys Asp Arg 
        835                 840                 845             


Thr Ser Met Ser Val Thr Leu Glu Gln Cys Ser Ile Leu Arg Asp Glu 
    850                 855                 860                 


His Gln Leu His Lys Asp Phe Phe Ile Arg Ala Leu Asp Cys Met Arg 
865                 870                 875                 880 


Arg Glu Gly Cys Arg Ile Glu Asn Val Leu Lys Asn Ile Lys Cys Arg 
                885                 890                 895     


Lys Tyr Ala Phe Asn Met Leu Gln Leu Met Ala Phe Pro Lys Tyr Tyr 
            900                 905                 910         


Arg Pro Pro Glu Gly Thr Tyr Gly Lys Ala Asp Thr 
        915                 920                 


<210>  1205
<211>  1244
<212>  PRT
<213>  Homo sapiens

<400>  1205

Met Asn Asn Gln Lys Val Val Ala Val Leu Leu Gln Glu Cys Lys Gln 
1               5                   10                  15      


Val Leu Asp Gln Leu Leu Leu Glu Ala Pro Asp Val Ser Glu Glu Asp 
            20                  25                  30          


Lys Ser Glu Asp Gln Arg Cys Arg Ala Leu Leu Pro Ser Glu Leu Arg 
        35                  40                  45              


Thr Leu Ile Gln Glu Ala Lys Glu Met Lys Trp Pro Phe Val Pro Glu 
    50                  55                  60                  


Lys Trp Gln Tyr Lys Gln Ala Val Gly Pro Glu Asp Lys Thr Asn Leu 
65                  70                  75                  80  


Lys Asp Val Ile Gly Ala Gly Leu Gln Gln Leu Leu Ala Ser Leu Arg 
                85                  90                  95      


Ala Ser Ile Leu Ala Arg Asp Cys Ala Ala Ala Ala Ala Ile Val Phe 
            100                 105                 110         


Leu Val Asp Arg Phe Leu Tyr Gly Leu Asp Val Ser Gly Lys Leu Leu 
        115                 120                 125             


Gln Val Ala Lys Gly Leu His Lys Leu Gln Pro Ala Thr Pro Ile Ala 
    130                 135                 140                 


Pro Gln Val Val Ile Arg Gln Ala Arg Ile Ser Val Asn Ser Gly Lys 
145                 150                 155                 160 


Leu Leu Lys Ala Glu Tyr Ile Leu Ser Ser Leu Ile Ser Asn Asn Gly 
                165                 170                 175     


Ala Thr Gly Thr Trp Leu Tyr Arg Asn Glu Ser Asp Lys Val Leu Val 
            180                 185                 190         


Gln Ser Val Cys Ile Gln Ile Arg Gly Gln Ile Leu Gln Lys Leu Gly 
        195                 200                 205             


Met Trp Tyr Glu Ala Ala Glu Leu Ile Trp Ala Ser Ile Val Gly Tyr 
    210                 215                 220                 


Leu Ala Leu Pro Gln Pro Asp Lys Lys Gly Leu Ser Thr Ser Leu Gly 
225                 230                 235                 240 


Ile Leu Ala Asp Ile Phe Val Ser Met Ser Lys Asn Asp Tyr Glu Lys 
                245                 250                 255     


Phe Lys Asn Asn Pro Gln Ile Asn Leu Ser Leu Leu Lys Glu Phe Asp 
            260                 265                 270         


His His Leu Leu Ser Ala Ala Glu Ala Cys Lys Leu Ala Ala Ala Phe 
        275                 280                 285             


Ser Ala Tyr Thr Pro Leu Phe Val Leu Thr Ala Val Asn Ile Arg Gly 
    290                 295                 300                 


Thr Cys Leu Leu Ser Tyr Ser Ser Ser Asn Asp Cys Pro Pro Glu Leu 
305                 310                 315                 320 


Lys Asn Leu His Leu Cys Glu Ala Lys Glu Ala Phe Glu Ile Gly Leu 
                325                 330                 335     


Leu Thr Lys Arg Asp Asp Glu Pro Val Thr Gly Lys Gln Glu Leu His 
            340                 345                 350         


Ser Phe Val Lys Ala Ala Phe Gly Leu Thr Thr Val His Arg Arg Leu 
        355                 360                 365             


His Gly Glu Thr Gly Thr Val His Ala Ala Ser Gln Leu Cys Lys Glu 
    370                 375                 380                 


Ala Met Gly Lys Leu Tyr Asn Phe Ser Thr Ser Ser Arg Ser Gln Asp 
385                 390                 395                 400 


Arg Glu Ala Leu Ser Gln Glu Val Met Ser Val Ile Ala Gln Val Lys 
                405                 410                 415     


Glu His Leu Gln Val Gln Ser Phe Ser Asn Val Asp Asp Arg Ser Tyr 
            420                 425                 430         


Val Pro Glu Ser Phe Glu Cys Arg Leu Asp Lys Leu Ile Leu His Gly 
        435                 440                 445             


Gln Gly Asp Phe Gln Lys Ile Leu Asp Thr Tyr Ser Gln His His Thr 
    450                 455                 460                 


Ser Val Cys Glu Val Phe Glu Ser Asp Cys Gly Asn Asn Lys Asn Glu 
465                 470                 475                 480 


Gln Lys Asp Ala Lys Thr Gly Val Cys Ile Thr Ala Leu Lys Thr Glu 
                485                 490                 495     


Ile Lys Asn Ile Asp Thr Val Ser Thr Thr Gln Glu Lys Pro His Cys 
            500                 505                 510         


Gln Arg Asp Thr Gly Ile Ser Ser Ser Leu Met Gly Lys Asn Val Gln 
        515                 520                 525             


Arg Glu Leu Arg Arg Gly Gly Arg Arg Asn Trp Thr His Ser Asp Ala 
    530                 535                 540                 


Phe Arg Val Ser Leu Asp Gln Asp Val Glu Thr Glu Thr Glu Pro Ser 
545                 550                 555                 560 


Asp Tyr Ser Asn Gly Glu Gly Ala Val Phe Asn Lys Ser Leu Ser Gly 
                565                 570                 575     


Ser Gln Thr Ser Ser Ala Trp Ser Asn Leu Ser Gly Phe Ser Ser Ser 
            580                 585                 590         


Ala Ser Trp Glu Glu Val Asn Tyr His Val Asp Asp Arg Ser Ala Arg 
        595                 600                 605             


Lys Glu Pro Gly Lys Glu His Leu Val Asp Thr Gln Cys Ser Thr Ala 
    610                 615                 620                 


Leu Ser Glu Glu Leu Glu Asn Asp Arg Glu Gly Arg Ala Met His Ser 
625                 630                 635                 640 


Leu His Ser Gln Leu His Asp Leu Ser Leu Gln Glu Pro Asn Asn Asp 
                645                 650                 655     


Asn Leu Glu Pro Ser Gln Asn Gln Pro Gln Gln Gln Met Pro Leu Thr 
            660                 665                 670         


Pro Phe Ser Pro His Asn Thr Pro Gly Ile Phe Leu Ala Pro Gly Ala 
        675                 680                 685             


Gly Leu Leu Glu Gly Ala Pro Glu Gly Ile Gln Glu Val Arg Asn Met 
    690                 695                 700                 


Gly Pro Arg Asn Thr Ser Ala His Ser Arg Pro Ser Tyr Arg Ser Ala 
705                 710                 715                 720 


Ser Trp Ser Ser Asp Ser Gly Arg Pro Lys Asn Met Gly Thr His Pro 
                725                 730                 735     


Ser Val Gln Lys Glu Glu Ala Phe Glu Ile Ile Val Glu Phe Pro Glu 
            740                 745                 750         


Thr Asn Cys Asp Val Lys Asp Arg Gln Gly Lys Glu Gln Gly Glu Glu 
        755                 760                 765             


Ile Ser Glu Arg Gly Ala Gly Pro Thr Phe Lys Ala Ser Pro Ser Trp 
    770                 775                 780                 


Val Asp Pro Glu Gly Glu Thr Ala Glu Ser Thr Glu Asp Ala Pro Leu 
785                 790                 795                 800 


Asp Phe His Arg Val Leu His Asn Ser Leu Gly Asn Ile Ser Met Leu 
                805                 810                 815     


Pro Cys Ser Ser Phe Thr Pro Asn Trp Pro Val Gln Asn Pro Asp Ser 
            820                 825                 830         


Arg Lys Ser Gly Gly Pro Val Ala Glu Gln Gly Ile Asp Pro Asp Ala 
        835                 840                 845             


Ser Thr Val Asp Glu Glu Gly Gln Leu Leu Asp Ser Met Asp Val Pro 
    850                 855                 860                 


Cys Thr Asn Gly His Gly Ser His Arg Leu Cys Ile Leu Arg Gln Pro 
865                 870                 875                 880 


Pro Gly Gln Arg Ala Glu Thr Pro Asn Ser Ser Val Ser Gly Asn Ile 
                885                 890                 895     


Leu Phe Pro Val Leu Ser Glu Asp Cys Thr Thr Thr Glu Glu Gly Asn 
            900                 905                 910         


Gln Pro Gly Asn Met Leu Asn Cys Ser Gln Asn Ser Ser Ser Ser Ser 
        915                 920                 925             


Val Trp Trp Leu Lys Ser Pro Ala Phe Ser Ser Gly Ser Ser Glu Gly 
    930                 935                 940                 


Asp Ser Pro Trp Ser Tyr Leu Asn Ser Ser Gly Ser Ser Trp Val Ser 
945                 950                 955                 960 


Leu Pro Gly Lys Met Arg Lys Glu Ile Leu Glu Ala Arg Thr Leu Gln 
                965                 970                 975     


Pro Asp Asp Phe Glu Lys Leu Leu Ala Gly Val Arg His Asp Trp Leu 
            980                 985                 990         


Phe Gln Arg Leu Glu Asn Thr Gly  Val Phe Lys Pro Ser  Gln Leu His 
        995                 1000                 1005             


Arg Ala  His Ser Ala Leu Leu  Leu Lys Tyr Ser Lys  Lys Ser Glu 
    1010                 1015                 1020             


Leu Trp  Thr Ala Gln Glu Thr  Ile Val Tyr Leu Gly  Asp Tyr Leu 
    1025                 1030                 1035             


Thr Val  Lys Lys Lys Gly Arg  Gln Arg Asn Ala Phe  Trp Val His 
    1040                 1045                 1050             


His Leu  His Gln Glu Glu Ile  Leu Gly Arg Tyr Val  Gly Lys Asp 
    1055                 1060                 1065             


Tyr Lys  Glu Gln Lys Gly Leu  Trp His His Phe Thr  Asp Val Glu 
    1070                 1075                 1080             


Arg Gln  Met Thr Ala Gln His  Tyr Val Thr Glu Phe  Asn Lys Arg 
    1085                 1090                 1095             


Leu Tyr  Glu Gln Asn Ile Pro  Thr Gln Ile Phe Tyr  Ile Pro Ser 
    1100                 1105                 1110             


Thr Ile  Leu Leu Ile Leu Glu  Asp Lys Thr Ile Lys  Gly Cys Ile 
    1115                 1120                 1125             


Ser Val  Glu Pro Tyr Ile Leu  Gly Glu Phe Val Lys  Leu Ser Asn 
    1130                 1135                 1140             


Asn Thr  Lys Val Val Lys Thr  Glu Tyr Lys Ala Thr  Glu Tyr Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Gly His Phe Ser  Tyr Glu Phe Ser Asn  His Arg Asp 
    1160                 1165                 1170             


Val Val  Val Asp Leu Gln Gly  Trp Val Thr Gly Asn  Gly Lys Gly 
    1175                 1180                 1185             


Leu Ile  Tyr Leu Thr Asp Pro  Gln Ile His Ser Val  Asp Gln Lys 
    1190                 1195                 1200             


Val Phe  Thr Thr Asn Phe Gly  Lys Arg Gly Ile Phe  Tyr Phe Phe 
    1205                 1210                 1215             


Asn Asn  Gln His Val Glu Cys  Asn Glu Ile Cys His  Arg Leu Ser 
    1220                 1225                 1230             


Leu Thr  Arg Pro Ser Met Glu  Lys Pro Cys Thr 
    1235                 1240                 


<210>  1206
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  1206

Met Val Asp Gly Val Met Ile Leu Pro Val Leu Ile Met Ile Ala Leu 
1               5                   10                  15      


Pro Ser Pro Ser Met Glu Asp Glu Lys Pro Lys Val Asn Pro Lys Leu 
            20                  25                  30          


Tyr Met Cys Val Cys Glu Gly Leu Ser Cys Gly Asn Glu Asp His Cys 
        35                  40                  45              


Glu Gly Gln Gln Cys Phe Ser Ser Leu Ser Ile Asn Asp Gly Phe His 
    50                  55                  60                  


Val Tyr Gln Lys Gly Cys Phe Gln Val Tyr Glu Gln Gly Lys Met Thr 
65                  70                  75                  80  


Cys Lys Thr Pro Pro Ser Pro Gly Gln Ala Val Glu Cys Cys Gln Gly 
                85                  90                  95      


Asp Trp Cys Asn Arg Asn Ile Thr Ala Gln Leu Pro Thr Lys Gly Lys 
            100                 105                 110         


Ser Phe Pro Gly Thr Gln Asn Phe His Leu Glu Val Gly Leu Ile Ile 
        115                 120                 125             


Leu Ser Val Val Phe Ala Val Cys Leu Leu Ala Cys Leu Leu Gly Val 
    130                 135                 140                 


Ala Leu Arg Lys Phe Lys Arg Arg Asn Gln Glu Arg Leu Asn Pro Arg 
145                 150                 155                 160 


Asp Val Glu Tyr Gly Thr Ile Glu Gly Leu Ile Thr Thr Asn Val Gly 
                165                 170                 175     


Asp Ser Thr Leu Ala Asp Leu Leu Asp His Ser Cys Thr Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Leu Pro Phe Leu Val Gln Arg Thr Val Ala Arg Gln Ile 
        195                 200                 205             


Thr Leu Leu Glu Cys Val Gly Lys Gly Arg Tyr Gly Glu Val Trp Arg 
    210                 215                 220                 


Gly Ser Trp Gln Gly Glu Asn Val Ala Val Lys Ile Phe Ser Ser Arg 
225                 230                 235                 240 


Asp Glu Lys Ser Trp Phe Arg Glu Thr Glu Leu Tyr Asn Thr Val Met 
                245                 250                 255     


Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ser Asp Met Thr Ser 
            260                 265                 270         


Arg His Ser Ser Thr Gln Leu Trp Leu Ile Thr His Tyr His Glu Met 
        275                 280                 285             


Gly Ser Leu Tyr Asp Tyr Leu Gln Leu Thr Thr Leu Asp Thr Val Ser 
    290                 295                 300                 


Cys Leu Arg Ile Val Leu Ser Ile Ala Ser Gly Leu Ala His Leu His 
305                 310                 315                 320 


Ile Glu Ile Phe Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp 
                325                 330                 335     


Leu Lys Ser Lys Asn Ile Leu Val Lys Lys Asn Gly Gln Cys Cys Ile 
            340                 345                 350         


Ala Asp Leu Gly Leu Ala Val Met His Ser Gln Ser Thr Asn Gln Leu 
        355                 360                 365             


Asp Val Gly Asn Asn Pro Arg Val Gly Thr Lys Arg Tyr Met Ala Pro 
    370                 375                 380                 


Glu Val Leu Asp Glu Thr Ile Gln Val Asp Cys Phe Asp Ser Tyr Lys 
385                 390                 395                 400 


Arg Val Asp Ile Trp Ala Phe Gly Leu Val Leu Trp Glu Val Ala Arg 
                405                 410                 415     


Arg Met Val Ser Asn Gly Ile Val Glu Asp Tyr Lys Pro Pro Phe Tyr 
            420                 425                 430         


Asp Val Val Pro Asn Asp Pro Ser Phe Glu Asp Met Arg Lys Val Val 
        435                 440                 445             


Cys Val Asp Gln Gln Arg Pro Asn Ile Pro Asn Arg Trp Phe Ser Asp 
    450                 455                 460                 


Pro Thr Leu Thr Ser Leu Ala Lys Leu Met Lys Glu Cys Trp Tyr Gln 
465                 470                 475                 480 


Asn Pro Ser Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Thr 
                485                 490                 495     


Lys Ile Asp Asn Ser Leu Asp Lys Leu Lys Thr Asp Cys 
            500                 505                 


<210>  1207
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  1207

Met Gly Lys Ala Ala Ala Ala Val Ala Phe Gly Ala Glu Val Gly Val 
1               5                   10                  15      


Arg Leu Ala Leu Phe Ala Ala Phe Leu Val Thr Glu Leu Leu Pro Pro 
            20                  25                  30          


Phe Gln Arg Leu Ile Gln Pro Glu Glu Met Trp Leu Tyr Arg Asn Pro 
        35                  40                  45              


Tyr Val Glu Ala Glu Tyr Phe Pro Thr Lys Pro Met Phe Val Ile Ala 
    50                  55                  60                  


Phe Leu Ser Pro Leu Ser Leu Ile Phe Leu Ala Lys Phe Leu Lys Lys 
65                  70                  75                  80  


Ala Asp Thr Arg Asp Ser Arg Gln Ala Cys Leu Ala Ala Ser Leu Ala 
                85                  90                  95      


Leu Ala Leu Asn Gly Val Phe Thr Asn Thr Ile Lys Leu Ile Val Gly 
            100                 105                 110         


Arg Pro Arg Pro Asp Phe Phe Tyr Arg Cys Phe Pro Asp Gly Leu Ala 
        115                 120                 125             


His Ser Asp Leu Met Cys Thr Gly Asp Lys Asp Val Val Asn Glu Gly 
    130                 135                 140                 


Arg Lys Ser Phe Pro Ser Gly His Ser Ser Phe Ala Phe Ala Gly Leu 
145                 150                 155                 160 


Ala Phe Ala Ser Phe Tyr Leu Ala Gly Lys Leu His Cys Phe Thr Pro 
                165                 170                 175     


Gln Gly Arg Gly Lys Ser Trp Arg Phe Cys Ala Phe Leu Ser Pro Leu 
            180                 185                 190         


Leu Phe Ala Ala Val Ile Ala Leu Ser Arg Thr Cys Asp Tyr Lys His 
        195                 200                 205             


His Trp Gln Asp Val Leu Val Gly Ser Met Ile Gly Met Thr Phe Ala 
    210                 215                 220                 


Tyr Val Cys Tyr Arg Gln Tyr Tyr Pro Pro Leu Thr Asp Ala Glu Cys 
225                 230                 235                 240 


His Lys Pro Phe Gln Asp Lys Leu Val Leu Ser Thr Ala Gln Lys Pro 
                245                 250                 255     


Gly Asp Ser Tyr Cys Phe Asp Ile 
            260                 


<210>  1208
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  1208

Met Gly Lys Ala Ala Ala Ala Val Ala Phe Gly Ala Glu Val Gly Val 
1               5                   10                  15      


Arg Leu Ala Leu Phe Ala Ala Phe Leu Val Thr Glu Leu Leu Pro Pro 
            20                  25                  30          


Phe Gln Arg Leu Ile Gln Pro Glu Glu Met Trp Leu Tyr Arg Asn Pro 
        35                  40                  45              


Tyr Val Glu Ala Glu Tyr Phe Pro Thr Lys Pro Met Phe Val Ile Ala 
    50                  55                  60                  


Phe Leu Ser Pro Leu Ser Leu Ile Phe Leu Ala Lys Phe Leu Lys Lys 
65                  70                  75                  80  


Ala Asp Thr Arg Asp Ser Arg Gln Ala Cys Leu Ala Ala Ser Leu Ala 
                85                  90                  95      


Leu Ala Leu Asn Gly Val Phe Thr Asn Thr Ile Lys Leu Ile Val Gly 
            100                 105                 110         


Arg Pro Arg Pro Asp Phe Phe Tyr Arg Cys Phe Pro Asp Gly Leu Ala 
        115                 120                 125             


His Ser Asp Leu Met Cys Thr Gly Asp Lys Asp Val Val Asn Glu Gly 
    130                 135                 140                 


Arg Lys Ser Phe Pro Ser Gly His Ser Ser Cys Met Asn Ile Ile Trp 
145                 150                 155                 160 


Thr Leu Pro Tyr Ala Cys Phe His Ile Ile Glu Phe Asn Leu Glu Ser 
                165                 170                 175     


<210>  1209
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  1209

Met Ser Phe Glu Gly Gly His Gly Gly Ser Arg Cys Arg Gly Ala Glu 
1               5                   10                  15      


Ser Gly Asp Ala Glu Pro Pro Pro Gln Pro Pro Pro Pro Pro Pro Pro 
            20                  25                  30          


Thr Pro Pro Pro Gly Glu Pro Ala Pro Val Pro Ala Ala Pro Arg Tyr 
        35                  40                  45              


Leu Pro Pro Leu Pro Ala Ser Pro Glu Thr Pro Glu Arg Ala Ala Gly 
    50                  55                  60                  


Pro Ser Glu Pro Leu Gly Glu Val Ala Pro Arg Cys Arg Gly Ala Asp 
65                  70                  75                  80  


Glu Leu Pro Pro Pro Pro Leu Pro Leu Gln Pro Ala Gly Gln Glu Val 
                85                  90                  95      


Ala Ala Ala Gly Asp Ser Gly Glu Gly Pro Arg Arg Leu Pro Glu Ala 
            100                 105                 110         


Ala Ala Ala Lys Gly Gly Pro Gly Glu Ser Glu Ala Gly Ala Gly Gly 
        115                 120                 125             


Glu Arg Glu Arg Arg Gly Ala Gly Asp Gln Pro Glu Thr Arg Ser Val 
    130                 135                 140                 


Cys Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Asp Gln Arg Ala Gly 
145                 150                 155                 160 


His Gln His Gln His His Gln Pro Ile Cys Lys Ile Cys Phe Gln Gly 
                165                 170                 175     


Ala Glu Gln Gly Glu Leu Leu Asn Pro Cys Arg Cys Asp Gly Ser Val 
            180                 185                 190         


Arg Tyr Thr His Gln Leu Cys Leu Leu Lys Trp Ile Ser Glu Arg Gly 
        195                 200                 205             


Ser Trp Thr Cys Glu Leu Cys Cys Tyr Arg Tyr His Val Ile Ala Ile 
    210                 215                 220                 


Lys Met Lys Gln Pro Cys Gln Trp Gln Ser Ile Ser Ile Thr Leu Val 
225                 230                 235                 240 


Glu Lys Val Gln Met Ile Ala Val Ile Leu Gly Ser Leu Phe Leu Ile 
                245                 250                 255     


Ala Ser Val Thr Trp Leu Leu Trp Ser Ala Phe Ser Pro Tyr Ala Val 
            260                 265                 270         


Trp Gln Arg Lys Asp Ile Leu Phe Gln Ile Cys Tyr Gly Met Tyr Gly 
        275                 280                 285             


Phe Met Asp Leu Val Cys Ile Gly Leu Ile Val His Glu Gly Ala Ala 
    290                 295                 300                 


Val Tyr Arg Val Phe Lys Arg Trp Arg Ala Val Asn Leu His Trp Asp 
305                 310                 315                 320 


Val Leu Asn Tyr Asp Lys Ala Thr Asp Ile Glu Glu Ser Ser Arg Gly 
                325                 330                 335     


Glu Ser Ser Thr Ser Arg Thr Leu Trp Leu Pro Leu Thr Ala Leu Arg 
            340                 345                 350         


Asn Arg Asn Leu Val His Pro Thr Gln Leu Thr Ser Pro Arg Phe Gln 
        355                 360                 365             


Cys Gly Tyr Val Leu Leu His Leu Phe Asn Arg Met Arg Pro His Glu 
    370                 375                 380                 


Asp Leu Ser Glu Asp Asn Ser Ser Gly Glu Val Val Met Arg Val Thr 
385                 390                 395                 400 


Ser Val 
        


<210>  1210
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  1210

Met Ala Gly Ser His Pro Tyr Leu Asn Pro Pro Asp Ser Thr His Pro 
1               5                   10                  15      


Ser Pro Pro Ser Ala Pro Pro Ser Leu Arg Trp His Gln Cys Cys Gln 
            20                  25                  30          


Pro Ser Asp Ala Thr Asn Gly Leu Leu Val Ala Leu Leu Gly Gly Gly 
        35                  40                  45              


Leu Pro Ala Gly Phe Val Gly Pro Leu Ser His Met Ala Tyr Gln Ala 
    50                  55                  60                  


Ser Asn Leu Pro Ser Leu Glu Leu Leu Ile Cys Arg Cys Leu Phe His 
65                  70                  75                  80  


Leu Pro Ile Ala Leu Leu Leu Lys Leu Arg Gly Asp Pro Leu Leu Gly 
                85                  90                  95      


Pro Pro Asp Ile Arg Gly Arg Ala Tyr Phe Tyr Ala Leu Leu Asn Val 
            100                 105                 110         


Leu Ser Ile Gly Cys Ala Tyr Ser Ala Val Gln Val Val Pro Ala Gly 
        115                 120                 125             


Asn Ala Ala Thr Val Arg Lys Gly Ser Ser Thr Val Cys Ser Ala Val 
    130                 135                 140                 


Leu Thr Leu Cys Leu Glu Ser Gln Gly Leu Ser Gly Tyr Asp Trp Cys 
145                 150                 155                 160 


Gly Leu Leu Gly Ser Ile Leu Gly Leu Ile Ile Ile Val Gly Pro Gly 
                165                 170                 175     


Leu Trp Thr Leu Gln Glu Gly Ile Thr Gly Val Tyr Thr Ala Leu Gly 
            180                 185                 190         


Tyr Gly Gln Ala Phe Val Gly Gly Leu Ala Leu Ser Leu Gly Leu Leu 
        195                 200                 205             


Val Tyr Arg Ser Leu His Phe Pro Ser Cys Leu Pro Thr Val Ala Phe 
    210                 215                 220                 


Leu Ser Gly Leu Val Gly Leu Leu Gly Ser Val Pro Gly Leu Phe Val 
225                 230                 235                 240 


Leu Gln Pro Pro Val Leu Pro Ser Asp Leu Pro Ser Trp Ser Cys Val 
                245                 250                 255     


Gly Ala Val Gly Ile Leu Ala Leu Val Ser Phe Thr Cys Val Ser Tyr 
            260                 265                 270         


Ala Val Thr Lys Ala His Pro Ala Leu Val Cys Ala Val Leu His Ser 
        275                 280                 285             


Glu Val Val Val Ala Leu Ile Leu Gln Tyr Tyr Met Leu His Glu Thr 
    290                 295                 300                 


Val Ala Pro Ser Asp Ile Val Gly Ala Gly Val Val Leu Gly Ser Ile 
305                 310                 315                 320 


Ala Ile Ile Thr Ala Trp Asn Leu Ser Cys Glu Arg Glu Gly Lys Val 
                325                 330                 335     


Glu Glu 
        


<210>  1211
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  1211

Met Val Thr Phe Ala Thr Ile Leu Gln Val Asn Lys Val Met Ser Ile 
1               5                   10                  15      


Leu Phe Tyr Val Ile Phe Leu Ala Tyr Leu Arg Gly Ile Gln Gly Asn 
            20                  25                  30          


Asn Met Asp Gln Arg Ser Leu Pro Glu Asp Ser Leu Asn Ser Leu Ile 
        35                  40                  45              


Ile Lys Leu Ile Gln Ala Asp Ile Leu Lys Asn Lys Leu Ser Lys Gln 
    50                  55                  60                  


Met Val Asp Val Lys Glu Asn Tyr Gln Ser Thr Leu Pro Lys Ala Glu 
65                  70                  75                  80  


Ala Pro Arg Glu Pro Glu Arg Gly Gly Pro Ala Lys Ser Ala Phe Gln 
                85                  90                  95      


Pro Val Ile Ala Met Asp Thr Glu Leu Leu Arg Gln Gln Arg Arg Tyr 
            100                 105                 110         


Asn Ser Pro Arg Val Leu Leu Ser Asp Ser Thr Pro Leu Glu Pro Pro 
        115                 120                 125             


Pro Leu Tyr Leu Met Glu Asp Tyr Val Gly Ser Pro Val Val Ala Asn 
    130                 135                 140                 


Arg Thr Ser Arg Arg Lys Arg Tyr Ala Glu His Lys Ser His Arg Gly 
145                 150                 155                 160 


Glu Tyr Ser Val Cys Asp Ser Glu Ser Leu Trp Val Thr Asp Lys Ser 
                165                 170                 175     


Ser Ala Ile Asp Ile Arg Gly His Gln Val Thr Val Leu Gly Glu Ile 
            180                 185                 190         


Lys Thr Gly Asn Ser Pro Val Lys Gln Tyr Phe Tyr Glu Thr Arg Cys 
        195                 200                 205             


Lys Glu Ala Arg Pro Val Lys Asn Gly Cys Arg Gly Ile Asp Asp Lys 
    210                 215                 220                 


His Trp Asn Ser Gln Cys Lys Thr Ser Gln Thr Tyr Val Arg Ala Leu 
225                 230                 235                 240 


Thr Ser Glu Asn Asn Lys Leu Val Gly Trp Arg Trp Ile Arg Ile Asp 
                245                 250                 255     


Thr Ser Cys Val Cys Ala Leu Ser Arg Lys Ile Gly Arg Thr 
            260                 265                 270 


<210>  1212
<211>  512
<212>  PRT
<213>  Homo sapiens

<400>  1212

Met Thr Ala Pro Trp Val Ala Leu Ala Leu Leu Trp Gly Ser Leu Cys 
1               5                   10                  15      


Ala Gly Ser Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr 
            20                  25                  30          


Asn Ala Asn Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Leu Glu Arg 
        35                  40                  45              


Cys Glu Gly Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg 
    50                  55                  60                  


Asn Ser Ser Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp 
65                  70                  75                  80  


Asp Phe Asn Cys Tyr Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn 
                85                  90                  95      


Pro Gln Val Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg 
            100                 105                 110         


Phe Thr His Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro 
        115                 120                 125             


Pro Pro Thr Ala Pro Thr Leu Leu Thr Val Leu Ala Tyr Ser Leu Leu 
    130                 135                 140                 


Pro Ile Gly Gly Leu Ser Leu Ile Val Leu Leu Ala Phe Trp Met Tyr 
145                 150                 155                 160 


Arg His Arg Lys Pro Pro Tyr Gly His Val Asp Ile His Glu Asp Pro 
                165                 170                 175     


Gly Pro Pro Pro Pro Ser Pro Leu Val Gly Leu Lys Pro Leu Gln Leu 
            180                 185                 190         


Leu Glu Ile Lys Ala Arg Gly Arg Phe Gly Cys Val Trp Lys Ala Gln 
        195                 200                 205             


Leu Met Asn Asp Phe Val Ala Val Lys Ile Phe Pro Leu Gln Asp Lys 
    210                 215                 220                 


Gln Ser Trp Gln Ser Glu Arg Glu Ile Phe Ser Thr Pro Gly Met Lys 
225                 230                 235                 240 


His Glu Asn Leu Leu Gln Phe Ile Ala Ala Glu Lys Arg Gly Ser Asn 
                245                 250                 255     


Leu Glu Val Glu Leu Trp Leu Ile Thr Ala Phe His Asp Lys Gly Ser 
            260                 265                 270         


Leu Thr Asp Tyr Leu Lys Gly Asn Ile Ile Thr Trp Asn Glu Leu Cys 
        275                 280                 285             


His Val Ala Glu Thr Met Ser Arg Gly Leu Ser Tyr Leu His Glu Asp 
    290                 295                 300                 


Val Pro Trp Cys Arg Gly Glu Gly His Lys Pro Ser Ile Ala His Arg 
305                 310                 315                 320 


Asp Phe Lys Ser Lys Asn Val Leu Leu Lys Ser Asp Leu Thr Ala Val 
                325                 330                 335     


Leu Ala Asp Phe Gly Leu Ala Val Arg Phe Glu Pro Gly Lys Pro Pro 
            340                 345                 350         


Gly Asp Thr His Gly Gln Val Gly Thr Arg Arg Tyr Met Ala Pro Glu 
        355                 360                 365             


Val Leu Glu Gly Ala Ile Asn Phe Gln Arg Asp Ala Phe Leu Arg Ile 
    370                 375                 380                 


Asp Met Tyr Ala Met Gly Leu Val Leu Trp Glu Leu Val Ser Arg Cys 
385                 390                 395                 400 


Lys Ala Ala Asp Gly Pro Val Asp Glu Tyr Met Leu Pro Phe Glu Glu 
                405                 410                 415     


Glu Ile Gly Gln His Pro Ser Leu Glu Glu Leu Gln Glu Val Val Val 
            420                 425                 430         


His Lys Lys Met Arg Pro Thr Ile Lys Asp His Trp Leu Lys His Pro 
        435                 440                 445             


Gly Leu Ala Gln Leu Cys Val Thr Ile Glu Glu Cys Trp Asp His Asp 
    450                 455                 460                 


Ala Glu Ala Arg Leu Ser Ala Gly Cys Val Glu Glu Arg Val Ser Leu 
465                 470                 475                 480 


Ile Arg Arg Ser Val Asn Gly Thr Thr Ser Asp Cys Leu Val Ser Leu 
                485                 490                 495     


Val Thr Ser Val Thr Asn Val Asp Leu Pro Pro Lys Glu Ser Ser Ile 
            500                 505                 510         


<210>  1213
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  1213

Met His Gln Ser Leu Thr Gln Gln Arg Ser Ser Asp Met Ser Leu Pro 
1               5                   10                  15      


Asp Ser Met Gly Ala Phe Asn Arg Arg Lys Arg Asn Ser Ile Tyr Val 
            20                  25                  30          


Thr Val Thr Leu Leu Ile Val Ser Val Leu Ile Leu Thr Val Gly Leu 
        35                  40                  45              


Ala Ala Thr Thr Arg Thr Gln Asn Val Thr Val Gly Gly Tyr Tyr Pro 
    50                  55                  60                  


Gly Val Ile Leu Gly Phe Gly Ser Phe Leu Gly Ile Ile Gly Ser Asn 
65                  70                  75                  80  


Leu Ile Glu Asn Lys Arg Gln Met Leu Val Ala Ser Ile Val Phe Ile 
                85                  90                  95      


Ser Phe Gly Val Ile Ala Ala Phe Cys Cys Ala Ile Val Asp Gly Val 
            100                 105                 110         


Phe Ala Ala Arg His Ile Asp Leu Lys Pro Leu Tyr Ala Asn Arg Cys 
        115                 120                 125             


His Tyr Val Pro Lys Thr Ser Gln Lys Glu Ala Glu Glu Val Asn Cys 
    130                 135                 140                 


Pro His Leu Ser Arg Glu Phe Cys Thr Pro Arg Ile Arg Gly Asn Thr 
145                 150                 155                 160 


Cys Phe Cys Cys Asp Leu Tyr Asn Cys Gly Asn Arg Val Glu Ile Thr 
                165                 170                 175     


Gly Gly Tyr Tyr Glu Tyr Ile Asp Val Ser Ser Cys Gln Asp Ile Ile 
            180                 185                 190         


His Leu Tyr His Leu Leu Trp Ser Ala Thr Ile Leu Asn Ile Val Gly 
        195                 200                 205             


Leu Phe Leu Gly Ile Ile Thr Ala Ala Val Leu Gly Gly Phe Lys Asp 
    210                 215                 220                 


Met Asn Pro Thr Leu Pro Ala Leu Asn Cys Ser Val Glu Asn Thr His 
225                 230                 235                 240 


Pro Thr Val Ser Tyr Tyr Ala His Pro Gln Val Ala Ser Tyr Asn Thr 
                245                 250                 255     


Tyr Tyr His Ser Pro Pro His Leu Pro Pro Tyr Ser Ala Tyr Asp Phe 
            260                 265                 270         


Gln His Ser Gly Val Phe Pro Ser Ser Pro Pro Ser Gly Leu Ser Asp 
        275                 280                 285             


Glu Pro Gln Ser Ala Ser Pro Ser Pro Ser Tyr Met Trp Ser Ser Ser 
    290                 295                 300                 


Ala Pro Pro Arg Tyr Ser Pro Pro Tyr Tyr Pro Pro Phe Glu Lys Pro 
305                 310                 315                 320 


Pro Pro Tyr Ser Pro 
                325 


<210>  1214
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  1214

Met His Gln Ser Leu Thr Gln Gln Arg Ser Ser Asp Met Ser Leu Pro 
1               5                   10                  15      


Asp Ser Met Gly Ala Phe Asn Arg Arg Lys Arg Asn Ser Ile Tyr Val 
            20                  25                  30          


Thr Val Thr Leu Leu Ile Val Ser Val Leu Ile Leu Thr Val Gly Leu 
        35                  40                  45              


Ala Ala Thr Thr Arg Thr Gln Asn Val Thr Val Gly Gly Tyr Tyr Pro 
    50                  55                  60                  


Gly Val Ile Leu Gly Phe Gly Ser Phe Leu Gly Ile Ile Gly Ser Asn 
65                  70                  75                  80  


Leu Ile Glu Asn Lys Arg Gln Met Leu Val Ala Ser Ile Val Phe Ile 
                85                  90                  95      


Ser Phe Gly Val Ile Ala Ala Phe Cys Cys Ala Ile Val Asp Gly Val 
            100                 105                 110         


Phe Ala Ala Arg His Ile Asp Leu Lys Pro Leu Tyr Ala Asn Arg Cys 
        115                 120                 125             


His Tyr Val Pro Lys Thr Ser Gln Lys Glu Ala Glu Glu Asn Pro Thr 
    130                 135                 140                 


Leu Pro Ala Leu Asn Cys Ser Val Glu Asn Thr His Pro Thr Val Ser 
145                 150                 155                 160 


Tyr Tyr Ala His Pro Gln Val Ala Ser Tyr Asn Thr Tyr Tyr His Ser 
                165                 170                 175     


Pro Pro His Leu Pro Pro Tyr Ser Ala Tyr Asp Phe Gln His Ser Gly 
            180                 185                 190         


Val Phe Pro Ser Ser Pro Pro Ser Gly Leu Ser Asp Glu Pro Gln Ser 
        195                 200                 205             


Ala Ser Pro Ser Pro Ser Tyr Met Trp Ser Ser Ser Ala Pro Pro Arg 
    210                 215                 220                 


Tyr Ser Pro Pro Tyr Tyr Pro Pro Phe Glu Lys Pro Pro Pro Tyr Ser 
225                 230                 235                 240 


Pro 
    


<210>  1215
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  1215

Met Leu Ser Leu Lys Leu Pro Arg Leu Phe Ser Ile Asp Gln Ile Pro 
1               5                   10                  15      


Gln Val Phe His Glu Gln Gly Ile Leu Phe Gly Tyr Arg His Pro Gln 
            20                  25                  30          


Ser Ser Ala Thr Ala Cys Ile Leu Ser Leu Phe Gln Met Thr Asn Glu 
        35                  40                  45              


Thr Leu Asn Ile Trp Thr His Leu Leu Pro Phe Trp Phe Phe Ala Trp 
    50                  55                  60                  


Arg Phe Val Thr Ala Leu Tyr Met Thr Asp Ile Lys Asn Asp Ser Tyr 
65                  70                  75                  80  


Ser Trp Pro Met Leu Val Tyr Met Cys Thr Ser Cys Val Tyr Pro Leu 
                85                  90                  95      


Val Ser Ser Cys Ala His Thr Phe Ser Ser Met Ser Lys Asn Ala Arg 
            100                 105                 110         


His Ile Cys Tyr Phe Leu Asp Tyr Gly Ala Val Asn Leu Phe Ser Leu 
        115                 120                 125             


Gly Ser Ala Ile Ala Tyr Ser Ala Tyr Thr Phe Pro Asp Ala Leu Met 
    130                 135                 140                 


Cys Thr Thr Phe His Asp Tyr Tyr Val Ala Leu Ala Val Leu Asn Thr 
145                 150                 155                 160 


Ile Leu Ser Thr Gly Leu Ser Cys Tyr Ser Arg Phe Leu Glu Ile Gln 
                165                 170                 175     


Lys Pro Arg Leu Cys Lys Val Ile Arg Val Leu Ala Phe Ala Tyr Pro 
            180                 185                 190         


Tyr Thr Trp Asp Ser Leu Pro Ile Phe Tyr Arg Leu Phe Leu Phe Pro 
        195                 200                 205             


Gly Glu Ser Ala Gln Asn Glu Ala Thr Ser Tyr His Gln Lys His Met 
    210                 215                 220                 


Ile Met Thr Leu Leu Ala Ser Phe Leu Tyr Ser Ala His Leu Pro Glu 
225                 230                 235                 240 


Arg Leu Ala Pro Gly Arg Phe Asp Tyr Ile Gly His Ser His Gln Leu 
                245                 250                 255     


Phe His Val Cys Val Ile Leu Ala Thr His Met Gln Met Glu Ala Ile 
            260                 265                 270         


Leu Leu Asp Lys Thr Leu Arg Lys Glu Trp Leu Leu Ala Thr Ser Lys 
        275                 280                 285             


Pro Phe Ser Phe Ser Gln Ile Ala Gly Ala Ile Leu Leu Cys Ile Ile 
    290                 295                 300                 


Phe Ser Leu Ser Asn Ile Ile Tyr Phe Ser Ala Ala Leu Tyr Arg Ile 
305                 310                 315                 320 


Pro Lys Pro Glu Leu His Lys Lys Glu Thr 
                325                 330 


<210>  1216
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  1216

Met Ala Phe Ser Asp Leu Thr Ser Arg Thr Val His Leu Tyr Asp Asn 
1               5                   10                  15      


Trp Ile Lys Asp Ala Asp Pro Arg Val Glu Asp Trp Leu Leu Met Ser 
            20                  25                  30          


Ser Pro Leu Pro Gln Thr Ile Leu Leu Gly Phe Tyr Val Tyr Phe Val 
        35                  40                  45              


Thr Ser Leu Gly Pro Lys Leu Met Glu Asn Arg Lys Pro Phe Glu Leu 
    50                  55                  60                  


Lys Lys Ala Met Ile Thr Tyr Asn Phe Phe Ile Val Leu Phe Ser Val 
65                  70                  75                  80  


Tyr Met Cys Tyr Glu Phe Val Met Ser Gly Trp Gly Ile Gly Tyr Ser 
                85                  90                  95      


Phe Arg Cys Asp Ile Val Asp Tyr Ser Arg Ser Pro Thr Ala Leu Arg 
            100                 105                 110         


Met Ala Arg Thr Cys Trp Leu Tyr Tyr Phe Ser Lys Phe Ile Glu Leu 
        115                 120                 125             


Leu Asp Thr Ile Phe Phe Val Leu Arg Lys Lys Asn Ser Gln Val Thr 
    130                 135                 140                 


Phe Leu His Val Phe His His Thr Ile Met Pro Trp Thr Trp Trp Phe 
145                 150                 155                 160 


Gly Val Lys Phe Ala Ala Gly Gly Leu Gly Thr Phe His Ala Leu Leu 
                165                 170                 175     


Asn Thr Ala Val His Val Val Met Tyr Ser Tyr Tyr Gly Leu Ser Ala 
            180                 185                 190         


Leu Gly Pro Ala Tyr Gln Lys Tyr Leu Trp Trp Lys Lys Tyr Leu Thr 
        195                 200                 205             


Ser Leu Gln Leu Val Gln Phe Val Ile Val Ala Ile His Ile Ser Gln 
    210                 215                 220                 


Phe Phe Phe Met Glu Asp Cys Lys Tyr Gln Phe Pro Val Phe Ala Cys 
225                 230                 235                 240 


Ile Ile Met Ser Tyr Ser Phe Met Phe Leu Leu Leu Phe Leu His Phe 
                245                 250                 255     


Trp Tyr Arg Ala Tyr Thr Lys Gly Gln Arg Leu Pro Lys Thr Val Lys 
            260                 265                 270         


Asn Gly Thr Cys Lys Asn Lys Asp Asn 
        275                 280     


<210>  1217
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  1217

Met Ala Ala Pro Thr Leu Gly Arg Leu Val Leu Thr His Leu Leu Val 
1               5                   10                  15      


Ala Leu Phe Gly Met Gly Ser Trp Ala Ala Val Asn Gly Ile Trp Val 
            20                  25                  30          


Glu Leu Pro Val Val Val Lys Asp Leu Pro Glu Gly Trp Ser Leu Pro 
        35                  40                  45              


Ser Tyr Leu Ser Val Val Val Ala Leu Gly Asn Leu Gly Leu Leu Val 
    50                  55                  60                  


Val Thr Leu Trp Arg Gln Leu Ala Pro Gly Lys Gly Glu Gln Val Pro 
65                  70                  75                  80  


Ile Gln Val Val Gln Val Leu Ser Val Val Gly Thr Ala Leu Leu Ala 
                85                  90                  95      


Pro Leu Trp His His Val Ala Pro Val Ala Gly Gln Leu His Ser Val 
            100                 105                 110         


Ala Phe Leu Thr Leu Ala Leu Val Leu Ala Met Ala Cys Cys Thr Ser 
        115                 120                 125             


Asn Val Thr Phe Leu Pro Phe Leu Ser His Leu Pro Pro Pro Phe Leu 
    130                 135                 140                 


Arg Ser Phe Phe Leu Gly Gln Gly Leu Ser Ala Leu Leu Pro Cys Val 
145                 150                 155                 160 


Leu Ala Leu Val Gln Gly Val Gly Arg Leu Glu Cys Pro Pro Ala Pro 
                165                 170                 175     


Thr Asn Gly Thr Ser Gly Pro Pro Leu Asp Phe Pro Glu Arg Phe Pro 
            180                 185                 190         


Ala Ser Thr Phe Phe Trp Ala Leu Thr Ala Leu Leu Val Thr Ser Ala 
        195                 200                 205             


Ala Ala Phe Arg Gly Leu Leu Leu Leu Leu Pro Ser Leu Pro Ser Val 
    210                 215                 220                 


Thr Thr Gly Gly Ser Gly Pro Glu Leu Gln Leu Gly Ser Pro Gly Ala 
225                 230                 235                 240 


Glu Glu Glu Glu Lys Glu Glu Glu Glu Ala Leu Pro Leu Gln Glu Pro 
                245                 250                 255     


Pro Ser Gln Ala Ala Gly Thr Ile Pro Gly Pro Asp Pro Glu Ala His 
            260                 265                 270         


Gln Leu Phe Ser Ala His Gly Ala Phe Leu Leu Gly Leu Met Ala Phe 
        275                 280                 285             


Thr Ser Ala Val Thr Asn Gly Val Leu Pro Ser Val Gln Ser Phe Ser 
    290                 295                 300                 


Cys Leu Pro Tyr Gly Arg Leu Ala Tyr His Leu Ala Val Val Leu Gly 
305                 310                 315                 320 


Ser Ala Ala Asn Pro Leu Ala Cys Phe Leu Ala Met Gly Val Leu Cys 
                325                 330                 335     


Arg Ser Leu Ala Gly Leu Val Gly Leu Ser Leu Leu Gly Met Leu Phe 
            340                 345                 350         


Gly Ala Tyr Leu Met Ala Leu Ala Ile Leu Ser Pro Cys Pro Pro Leu 
        355                 360                 365             


Val Gly Thr Thr Ala Gly Val Val Leu Val Val Leu Ser Trp Val Leu 
    370                 375                 380                 


Cys Leu Cys Val Phe Ser Tyr Val Lys Val Ala Ala Ser Ser Leu Leu 
385                 390                 395                 400 


His Gly Gly Gly Arg Pro Ala Leu Leu Ala Ala Gly Val Ala Ile Gln 
                405                 410                 415     


Val Gly Ser Leu Leu Gly Ala Gly Ala Met Phe Pro Pro Thr Ser Ile 
            420                 425                 430         


Tyr His Val Phe Gln Ser Arg Lys Asp Cys Val Asp Pro Cys Gly Pro 
        435                 440                 445             


<210>  1218
<211>  1101
<212>  PRT
<213>  Homo sapiens

<400>  1218

Met Glu Ser Leu Leu Leu Pro Val Leu Leu Leu Leu Ala Ile Leu Trp 
1               5                   10                  15      


Thr Gln Ala Ala Ala Leu Ile Asn Leu Lys Tyr Ser Val Glu Glu Glu 
            20                  25                  30          


Gln Arg Ala Gly Thr Val Ile Ala Asn Val Ala Lys Asp Ala Arg Glu 
        35                  40                  45              


Ala Gly Phe Ala Leu Asp Pro Arg Gln Ala Ser Ala Phe Arg Val Val 
    50                  55                  60                  


Ser Asn Ser Ala Pro His Leu Val Asp Ile Asn Pro Ser Ser Gly Leu 
65                  70                  75                  80  


Leu Val Thr Lys Gln Lys Ile Asp Arg Asp Leu Leu Cys Arg Gln Ser 
                85                  90                  95      


Pro Lys Cys Ile Ile Ser Leu Glu Val Met Ser Ser Ser Met Glu Ile 
            100                 105                 110         


Cys Val Ile Lys Val Glu Ile Lys Asp Leu Asn Asp Asn Ala Pro Ser 
        115                 120                 125             


Phe Pro Ala Ala Gln Ile Glu Leu Glu Ile Ser Glu Ala Ala Ser Pro 
    130                 135                 140                 


Gly Thr Arg Ile Pro Leu Asp Ser Ala Tyr Asp Pro Asp Ser Gly Ser 
145                 150                 155                 160 


Phe Gly Val Gln Thr Tyr Glu Leu Thr Pro Asn Glu Leu Phe Gly Leu 
                165                 170                 175     


Glu Ile Lys Thr Arg Gly Asp Gly Ser Arg Phe Ala Glu Leu Val Val 
            180                 185                 190         


Glu Lys Ser Leu Asp Arg Glu Thr Gln Ser His Tyr Ser Phe Arg Ile 
        195                 200                 205             


Thr Ala Leu Asp Gly Gly Asp Pro Pro Arg Leu Gly Thr Val Gly Leu 
    210                 215                 220                 


Ser Ile Lys Val Thr Asp Ser Asn Asp Asn Asn Pro Val Phe Ser Glu 
225                 230                 235                 240 


Ser Thr Tyr Ala Val Ser Val Pro Glu Asn Ser Pro Pro Asn Thr Pro 
                245                 250                 255     


Val Ile Arg Leu Asn Ala Ser Asp Pro Asp Glu Gly Thr Asn Gly Gln 
            260                 265                 270         


Val Val Tyr Ser Phe Tyr Gly Tyr Val Asn Asp Arg Thr Arg Glu Leu 
        275                 280                 285             


Phe Gln Ile Asp Pro His Ser Gly Leu Val Thr Val Thr Gly Ala Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Gly His Val Tyr Glu Leu Asp Val Gln Ala Lys Asp 
305                 310                 315                 320 


Leu Gly Pro Asn Ser Ile Pro Ala His Cys Lys Val Thr Val Ser Val 
                325                 330                 335     


Leu Asp Thr Asn Asp Asn Pro Pro Val Ile Asn Leu Leu Ser Val Asn 
            340                 345                 350         


Ser Glu Leu Val Glu Val Ser Glu Ser Ala Pro Pro Gly Tyr Val Ile 
        355                 360                 365             


Ala Leu Val Arg Val Ser Asp Arg Asp Ser Gly Leu Asn Gly Arg Val 
    370                 375                 380                 


Gln Cys Arg Leu Leu Gly Asn Val Pro Phe Arg Leu Gln Glu Tyr Glu 
385                 390                 395                 400 


Ser Phe Ser Thr Ile Leu Val Asp Gly Arg Leu Asp Arg Glu Gln His 
                405                 410                 415     


Asp Gln Tyr Asn Leu Thr Ile Gln Ala Arg Asp Gly Gly Val Pro Met 
            420                 425                 430         


Leu Gln Ser Ala Lys Ser Phe Thr Val Leu Ile Thr Asp Glu Asn Asp 
        435                 440                 445             


Asn His Pro His Phe Ser Lys Pro Tyr Tyr Gln Val Ile Val Gln Glu 
    450                 455                 460                 


Asn Asn Thr Pro Gly Ala Tyr Leu Leu Ser Val Ser Ala Arg Asp Pro 
465                 470                 475                 480 


Asp Leu Gly Leu Asn Gly Ser Val Ser Tyr Gln Ile Val Pro Ser Gln 
                485                 490                 495     


Val Arg Asp Met Pro Val Phe Thr Tyr Val Ser Ile Asn Pro Asn Ser 
            500                 505                 510         


Gly Asp Ile Tyr Ala Leu Arg Ser Phe Asn His Glu Gln Thr Lys Ala 
        515                 520                 525             


Phe Glu Phe Lys Val Leu Ala Lys Asp Gly Gly Leu Pro Ser Leu Gln 
    530                 535                 540                 


Ser Asn Ala Thr Val Arg Val Ile Ile Leu Asp Val Asn Asp Asn Thr 
545                 550                 555                 560 


Pro Val Ile Thr Ala Pro Pro Leu Ile Asn Gly Thr Ala Glu Val Tyr 
                565                 570                 575     


Ile Pro Arg Asn Ser Gly Ile Gly Tyr Leu Val Thr Val Val Lys Ala 
            580                 585                 590         


Glu Asp Tyr Asp Glu Gly Glu Asn Gly Arg Val Thr Tyr Asp Met Thr 
        595                 600                 605             


Glu Gly Asp Arg Gly Phe Phe Glu Ile Asp Gln Val Asn Gly Glu Val 
    610                 615                 620                 


Arg Thr Thr Arg Thr Phe Gly Glu Ser Ser Lys Ser Ser Tyr Glu Leu 
625                 630                 635                 640 


Ile Val Val Ala His Asp His Gly Lys Thr Ser Leu Ser Ala Ser Ala 
                645                 650                 655     


Leu Val Leu Ile Tyr Leu Ser Pro Ala Leu Asp Ala Gln Glu Ser Met 
            660                 665                 670         


Gly Ser Val Asn Leu Ser Leu Ile Phe Ile Ile Ala Leu Gly Ser Ile 
        675                 680                 685             


Ala Gly Ile Leu Phe Val Thr Met Ile Phe Val Ala Ile Lys Cys Lys 
    690                 695                 700                 


Arg Asp Asn Lys Glu Ile Arg Thr Tyr Asn Cys Arg Ile Ala Glu Tyr 
705                 710                 715                 720 


Ser Tyr Gly His Gln Lys Lys Ser Ser Lys Lys Lys Lys Ile Ser Lys 
                725                 730                 735     


Asn Asp Ile Arg Leu Val Pro Arg Asp Val Glu Glu Thr Asp Lys Met 
            740                 745                 750         


Asn Val Val Ser Cys Ser Ser Leu Thr Ser Ser Leu Asn Tyr Phe Asp 
        755                 760                 765             


Tyr His Gln Gln Thr Leu Pro Leu Gly Cys Arg Arg Ser Glu Ser Thr 
    770                 775                 780                 


Phe Leu Asn Val Glu Asn Gln Asn Thr Arg Asn Thr Ser Ala Asn His 
785                 790                 795                 800 


Ile Tyr His His Ser Phe Asn Ser Gln Gly Pro Gln Gln Pro Asp Leu 
                805                 810                 815     


Ile Ile Asn Gly Val Pro Leu Pro Glu Thr Glu Asn Tyr Ser Phe Asp 
            820                 825                 830         


Ser Asn Tyr Val Asn Ser Arg Ala His Leu Ile Lys Ser Ser Ser Thr 
        835                 840                 845             


Phe Lys Asp Leu Glu Gly Asn Ser Leu Lys Asp Ser Gly His Glu Glu 
    850                 855                 860                 


Ser Asp Gln Thr Asp Ser Glu His Asp Val Gln Arg Ser Leu Tyr Cys 
865                 870                 875                 880 


Asp Thr Ala Val Asn Asp Val Leu Asn Thr Ser Val Thr Ser Met Gly 
                885                 890                 895     


Ser Gln Met Pro Asp His Asp Gln Asn Glu Gly Phe His Cys Arg Glu 
            900                 905                 910         


Glu Cys Arg Ile Leu Gly His Ser Asp Arg Cys Trp Met Pro Arg Asn 
        915                 920                 925             


Pro Met Pro Ile Arg Ser Lys Ser Pro Glu His Val Arg Asn Ile Ile 
    930                 935                 940                 


Ala Leu Ser Ile Glu Ala Thr Ala Ala Asp Val Glu Ala Tyr Asp Asp 
945                 950                 955                 960 


Cys Gly Pro Thr Lys Arg Thr Phe Ala Thr Phe Gly Lys Asp Val Ser 
                965                 970                 975     


Asp His Pro Ala Glu Glu Arg Pro Thr Leu Lys Gly Lys Arg Thr Val 
            980                 985                 990         


Asp Val Thr Ile Cys Ser Pro Lys  Val Asn Ser Val Ile  Arg Glu Ala 
        995                 1000                 1005             


Gly Asn  Gly Cys Glu Ala Ile  Ser Pro Val Thr Ser  Pro Leu His 
    1010                 1015                 1020             


Leu Lys  Ser Ser Leu Pro Thr  Lys Pro Ser Val Ser  Tyr Thr Ile 
    1025                 1030                 1035             


Ala Leu  Ala Pro Pro Ala Arg  Asp Leu Glu Gln Tyr  Val Asn Asn 
    1040                 1045                 1050             


Val Asn  Asn Gly Pro Thr Arg  Pro Ser Glu Ala Glu  Pro Arg Gly 
    1055                 1060                 1065             


Ala Asp  Ser Glu Lys Val Met  His Glu Val Ser Pro  Ile Leu Lys 
    1070                 1075                 1080             


Glu Gly  Arg Asn Lys Glu Ser  Pro Gly Val Lys Arg  Leu Lys Asp 
    1085                 1090                 1095             


Ile Val  Leu 
    1100     


<210>  1219
<211>  1465
<212>  PRT
<213>  Homo sapiens

<400>  1219

Met Arg Gly Leu Gly Thr Cys Leu Ala Thr Leu Ala Gly Leu Leu Leu 
1               5                   10                  15      


Thr Ala Ala Gly Glu Thr Phe Ser Gly Gly Cys Leu Phe Asp Glu Pro 
            20                  25                  30          


Tyr Ser Thr Cys Gly Tyr Ser Gln Ser Glu Gly Asp Asp Phe Asn Trp 
        35                  40                  45              


Glu Gln Val Asn Thr Leu Thr Lys Pro Thr Ser Asp Pro Trp Met Pro 
    50                  55                  60                  


Ser Gly Ser Phe Met Leu Val Asn Ala Ser Gly Arg Pro Glu Gly Gln 
65                  70                  75                  80  


Arg Ala His Leu Leu Leu Pro Gln Leu Lys Glu Asn Asp Thr His Cys 
                85                  90                  95      


Ile Asp Phe His Tyr Phe Val Ser Ser Lys Ser Asn Ser Pro Pro Gly 
            100                 105                 110         


Leu Leu Asn Val Tyr Val Lys Val Asn Asn Gly Pro Leu Gly Asn Pro 
        115                 120                 125             


Ile Trp Asn Ile Ser Gly Asp Pro Thr Arg Thr Trp Asn Arg Ala Glu 
    130                 135                 140                 


Leu Ala Ile Ser Thr Phe Trp Pro Asn Phe Tyr Gln Val Ile Phe Glu 
145                 150                 155                 160 


Val Ile Thr Ser Gly His Gln Gly Tyr Leu Ala Ile Asp Glu Val Lys 
                165                 170                 175     


Val Leu Gly His Pro Cys Thr Arg Thr Pro His Phe Leu Arg Ile Gln 
            180                 185                 190         


Asn Val Glu Val Asn Ala Gly Gln Phe Ala Thr Phe Gln Cys Ser Ala 
        195                 200                 205             


Ile Gly Arg Thr Val Ala Gly Asp Arg Leu Trp Leu Gln Gly Ile Asp 
    210                 215                 220                 


Val Arg Asp Ala Pro Leu Lys Glu Ile Lys Val Thr Ser Ser Arg Arg 
225                 230                 235                 240 


Phe Ile Ala Ser Phe Asn Val Val Asn Thr Thr Lys Arg Asp Ala Gly 
                245                 250                 255     


Lys Tyr Arg Cys Met Ile Arg Thr Glu Gly Gly Val Gly Ile Ser Asn 
            260                 265                 270         


Tyr Ala Glu Leu Val Val Lys Glu Pro Pro Val Pro Ile Ala Pro Pro 
        275                 280                 285             


Gln Leu Ala Ser Val Gly Ala Thr Tyr Leu Trp Ile Gln Leu Asn Ala 
    290                 295                 300                 


Asn Ser Ile Asn Gly Asp Gly Pro Ile Val Ala Arg Glu Val Glu Tyr 
305                 310                 315                 320 


Cys Thr Ala Ser Gly Ser Trp Asn Asp Arg Gln Pro Val Asp Ser Thr 
                325                 330                 335     


Ser Tyr Lys Ile Gly His Leu Asp Pro Asp Thr Glu Tyr Glu Ile Ser 
            340                 345                 350         


Val Leu Leu Thr Arg Pro Gly Glu Gly Gly Thr Gly Ser Pro Gly Pro 
        355                 360                 365             


Ala Leu Arg Thr Arg Thr Lys Cys Ala Asp Pro Met Arg Gly Pro Arg 
    370                 375                 380                 


Lys Leu Glu Val Val Glu Val Lys Ser Arg Gln Ile Thr Ile Arg Trp 
385                 390                 395                 400 


Glu Pro Phe Gly Tyr Asn Val Thr Arg Cys His Ser Tyr Asn Leu Thr 
                405                 410                 415     


Val His Tyr Cys Tyr Gln Val Gly Gly Gln Glu Gln Val Arg Glu Glu 
            420                 425                 430         


Val Ser Trp Asp Thr Glu Asn Ser His Pro Gln His Thr Ile Thr Asn 
        435                 440                 445             


Leu Ser Pro Tyr Thr Asn Val Ser Val Lys Leu Ile Leu Met Asn Pro 
    450                 455                 460                 


Glu Gly Arg Lys Glu Ser Gln Glu Leu Ile Val Gln Thr Asp Glu Asp 
465                 470                 475                 480 


Leu Pro Gly Ala Val Pro Thr Glu Ser Ile Gln Gly Ser Thr Phe Glu 
                485                 490                 495     


Glu Lys Ile Phe Leu Gln Trp Arg Glu Pro Thr Gln Thr Tyr Gly Val 
            500                 505                 510         


Ile Thr Leu Tyr Glu Ile Thr Tyr Lys Ala Val Ser Ser Phe Asp Pro 
        515                 520                 525             


Glu Ile Asp Leu Ser Asn Gln Ser Gly Arg Val Ser Lys Leu Gly Asn 
    530                 535                 540                 


Glu Thr His Phe Leu Phe Phe Gly Leu Tyr Pro Gly Thr Thr Tyr Ser 
545                 550                 555                 560 


Phe Thr Ile Arg Ala Ser Thr Ala Lys Gly Phe Gly Pro Pro Ala Thr 
                565                 570                 575     


Asn Gln Phe Thr Thr Lys Ile Ser Ala Pro Ser Met Pro Ala Tyr Glu 
            580                 585                 590         


Leu Glu Thr Pro Leu Asn Gln Thr Asp Asn Thr Val Thr Val Met Leu 
        595                 600                 605             


Lys Pro Ala His Ser Arg Gly Ala Pro Val Ser Val Tyr Gln Ile Val 
    610                 615                 620                 


Val Glu Glu Glu Arg Pro Arg Arg Thr Lys Lys Thr Thr Glu Ile Leu 
625                 630                 635                 640 


Lys Cys Tyr Pro Val Pro Ile His Phe Gln Asn Ala Ser Leu Leu Asn 
                645                 650                 655     


Ser Gln Tyr Tyr Phe Ala Ala Glu Phe Pro Ala Asp Ser Leu Gln Ala 
            660                 665                 670         


Ala Gln Pro Phe Thr Ile Gly Asp Asn Lys Thr Tyr Asn Gly Tyr Trp 
        675                 680                 685             


Asn Thr Pro Leu Leu Pro Tyr Lys Ser Tyr Arg Ile Tyr Phe Gln Ala 
    690                 695                 700                 


Ala Ser Arg Ala Asn Gly Glu Thr Lys Ile Asp Cys Val Gln Val Ala 
705                 710                 715                 720 


Thr Lys Gly Ala Ala Thr Pro Lys Pro Val Pro Glu Pro Glu Lys Gln 
                725                 730                 735     


Thr Asp His Thr Val Lys Ile Ala Gly Val Ile Ala Gly Ile Leu Leu 
            740                 745                 750         


Phe Val Ile Ile Phe Leu Gly Val Val Leu Val Met Lys Lys Arg Lys 
        755                 760                 765             


Leu Ala Lys Lys Arg Lys Glu Thr Met Ser Ser Thr Arg Gln Glu Met 
    770                 775                 780                 


Thr Val Met Val Asn Ser Met Asp Lys Ser Tyr Ala Glu Gln Gly Thr 
785                 790                 795                 800 


Asn Cys Asp Glu Ala Phe Ser Phe Met Asp Thr His Asn Leu Asn Gly 
                805                 810                 815     


Arg Ser Val Ser Ser Pro Ser Ser Phe Thr Met Lys Thr Asn Thr Leu 
            820                 825                 830         


Ser Thr Ser Val Pro Asn Ser Tyr Tyr Pro Asp Pro Phe Val Pro Thr 
        835                 840                 845             


Ala Ile Leu Val Pro Ile Asn Asp Glu Thr His Thr Met Ala Ser Asp 
    850                 855                 860                 


Thr Ser Ser Leu Val Gln Ser His Thr Tyr Lys Lys Arg Glu Pro Ala 
865                 870                 875                 880 


Asp Val Pro Tyr Gln Thr Gly Gln Leu His Pro Ala Ile Arg Val Ala 
                885                 890                 895     


Asp Leu Leu Gln His Ile Thr Gln Met Lys Cys Ala Glu Gly Tyr Gly 
            900                 905                 910         


Phe Lys Glu Glu Tyr Glu Ser Phe Phe Glu Gly Gln Ser Ala Pro Trp 
        915                 920                 925             


Asp Ser Ala Lys Lys Asp Glu Asn Arg Met Lys Asn Arg Tyr Gly Asn 
    930                 935                 940                 


Ile Ile Ala Tyr Asp His Ser Arg Val Arg Leu Gln Thr Ile Glu Gly 
945                 950                 955                 960 


Asp Thr Asn Ser Asp Tyr Ile Asn Gly Asn Tyr Ile Asp Gly Tyr His 
                965                 970                 975     


Arg Pro Asn His Tyr Ile Ala Thr Gln Gly Pro Met Gln Glu Thr Ile 
            980                 985                 990         


Tyr Asp Phe Trp Arg Met Val Trp  His Glu Asn Thr Ala  Ser Ile Ile 
        995                 1000                 1005             


Met Val  Thr Asn Leu Val Glu  Val Gly Arg Val Lys  Cys Cys Lys 
    1010                 1015                 1020             


Tyr Trp  Pro Asp Asp Thr Glu  Ile Tyr Lys Asp Ile  Lys Val Thr 
    1025                 1030                 1035             


Leu Ile  Glu Thr Glu Leu Leu  Ala Glu Tyr Val Ile  Arg Thr Phe 
    1040                 1045                 1050             


Ala Val  Glu Lys Arg Gly Val  His Glu Ile Arg Glu  Ile Arg Gln 
    1055                 1060                 1065             


Phe His  Phe Thr Gly Trp Pro  Asp His Gly Val Pro  Tyr His Ala 
    1070                 1075                 1080             


Thr Gly  Leu Leu Gly Phe Val  Arg Gln Val Lys Ser  Lys Ser Pro 
    1085                 1090                 1095             


Pro Ser  Ala Gly Pro Leu Val  Val His Cys Ser Ala  Gly Ala Gly 
    1100                 1105                 1110             


Arg Thr  Gly Cys Phe Ile Val  Ile Asp Ile Met Leu  Asp Met Ala 
    1115                 1120                 1125             


Glu Arg  Glu Gly Val Val Asp  Ile Tyr Asn Cys Val  Arg Glu Leu 
    1130                 1135                 1140             


Arg Ser  Arg Arg Val Asn Met  Val Gln Thr Glu Glu  Gln Tyr Val 
    1145                 1150                 1155             


Phe Ile  His Asp Ala Ile Leu  Glu Ala Cys Leu Cys  Gly Asp Thr 
    1160                 1165                 1170             


Ser Val  Pro Ala Ser Gln Val  Arg Ser Leu Tyr Tyr  Asp Met Asn 
    1175                 1180                 1185             


Lys Leu  Asp Pro Gln Thr Asn  Ser Ser Gln Ile Lys  Glu Glu Phe 
    1190                 1195                 1200             


Arg Thr  Leu Asn Met Val Thr  Pro Thr Leu Arg Val  Glu Asp Cys 
    1205                 1210                 1215             


Ser Ile  Ala Leu Leu Pro Arg  Asn His Glu Lys Asn  Arg Cys Met 
    1220                 1225                 1230             


Asp Ile  Leu Pro Pro Asp Arg  Cys Leu Pro Phe Leu  Ile Thr Ile 
    1235                 1240                 1245             


Asp Gly  Glu Ser Ser Asn Tyr  Ile Asn Ala Ala Leu  Met Asp Ser 
    1250                 1255                 1260             


Tyr Lys  Gln Pro Ser Ala Phe  Ile Val Thr Gln His  Pro Leu Pro 
    1265                 1270                 1275             


Asn Thr  Val Lys Asp Phe Trp  Arg Leu Val Leu Asp  Tyr His Cys 
    1280                 1285                 1290             


Thr Ser  Val Val Met Leu Asn  Asp Val Asp Pro Ala  Gln Leu Cys 
    1295                 1300                 1305             


Pro Gln  Tyr Trp Pro Glu Asn  Gly Val His Arg His  Gly Pro Ile 
    1310                 1315                 1320             


Gln Val  Glu Phe Val Ser Ala  Asp Leu Glu Glu Asp  Ile Ile Ser 
    1325                 1330                 1335             


Arg Ile  Phe Arg Ile Tyr Asn  Ala Ala Arg Pro Gln  Asp Gly Tyr 
    1340                 1345                 1350             


Arg Met  Val Gln Gln Phe Gln  Phe Leu Gly Trp Pro  Met Tyr Arg 
    1355                 1360                 1365             


Asp Thr  Pro Val Ser Lys Arg  Ser Phe Leu Lys Leu  Ile Arg Gln 
    1370                 1375                 1380             


Val Asp  Lys Trp Gln Glu Glu  Tyr Asn Gly Gly Glu  Gly Arg Thr 
    1385                 1390                 1395             


Val Val  His Cys Leu Asn Gly  Gly Gly Arg Ser Gly  Thr Phe Cys 
    1400                 1405                 1410             


Ala Ile  Ser Ile Val Cys Glu  Met Leu Arg His Gln  Arg Thr Val 
    1415                 1420                 1425             


Asp Val  Phe His Ala Val Lys  Thr Leu Arg Asn Asn  Lys Pro Asn 
    1430                 1435                 1440             


Met Val  Asp Leu Leu Asp Gln  Tyr Lys Phe Cys Tyr  Glu Val Ala 
    1445                 1450                 1455             


Leu Glu  Tyr Leu Asn Ser Gly  
    1460                 1465 


<210>  1220
<211>  1006
<212>  PRT
<213>  Homo sapiens

<400>  1220

Met Ser Ala Tyr Tyr Arg Asn Asn Trp Ser Glu Glu Asp Pro Asp Tyr 
1               5                   10                  15      


Pro Asp Tyr Ser Gly Ser Gln Asn Arg Thr Gln Gly Tyr Leu Lys Thr 
            20                  25                  30          


Gln Gly Tyr Pro Asp Val Pro Gly Pro Leu Asn Asn Pro Asp Tyr Pro 
        35                  40                  45              


Gly Thr Arg Ser Asn Pro Tyr Ser Val Ala Ser Arg Thr Arg Pro Asp 
    50                  55                  60                  


Tyr Pro Gly Ser Leu Ala Glu Pro Asn Tyr Pro Arg Ser Leu Ser Asn 
65                  70                  75                  80  


Pro Asp Tyr Ser Gly Thr Arg Ser Asn Ala Tyr Ser Ala Ala Ser Arg 
                85                  90                  95      


Thr Ser Pro Asp His Pro Thr Ser Leu Pro Glu Pro Asp Tyr Ser Glu 
            100                 105                 110         


Phe Gln Ser His Pro Tyr His Arg Ala Ser Ser Arg Gln Pro Asp Tyr 
        115                 120                 125             


Pro Gly Ser Gln Arg Asn Pro Asp Phe Ala Gly Ser Ser Ser Ser Gly 
    130                 135                 140                 


Asn Tyr Ala Gly Ser Arg Thr His Pro Asp His Phe Gly Ser Leu Glu 
145                 150                 155                 160 


Pro Asp Tyr Pro Gly Ala Gln Ser Asn Ser Asp His Pro Gly Pro Arg 
                165                 170                 175     


Ala Asn Leu Asn His Pro Gly Ser Arg Lys Asn Leu Glu His Thr Ser 
            180                 185                 190         


Phe Arg Ile Asn Pro Tyr Ala Asp Ser Leu Gly Lys Pro Asp Tyr Pro 
        195                 200                 205             


Gly Ala Asp Ile Gln Pro Asn Ser Pro Pro Phe Phe Gly Glu Pro Asp 
    210                 215                 220                 


Tyr Pro Ser Ala Glu Asp Asn Gln Asn Leu Pro Ser Thr Trp Arg Glu 
225                 230                 235                 240 


Pro Asp Tyr Ser Asp Ala Glu Asn Gly His Asp Tyr Gly Ser Ser Glu 
                245                 250                 255     


Thr Pro Lys Met Thr Arg Gly Val Leu Ser Arg Thr Ser Ser Ile Gln 
            260                 265                 270         


Pro Ser Phe Arg His Arg Ser Asp Asp Pro Val Gly Ser Leu Trp Gly 
        275                 280                 285             


Glu Asn Asp Tyr Pro Glu Gly Ile Glu Met Ala Ser Met Glu Met Ala 
    290                 295                 300                 


Asn Ser Tyr Gly His Ser Leu Pro Gly Ala Pro Gly Ser Gly Tyr Val 
305                 310                 315                 320 


Asn Pro Ala Tyr Val Gly Glu Ser Gly Pro Val His Ala Tyr Gly Asn 
                325                 330                 335     


Pro Pro Leu Ser Glu Cys Asp Trp His Lys Ser Pro Gln Gly Gln Lys 
            340                 345                 350         


Leu Ile Ala Ser Leu Ile Pro Met Thr Ser Arg Asp Arg Ile Lys Ala 
        355                 360                 365             


Ile Arg Asn Gln Pro Arg Thr Met Glu Glu Lys Arg Asn Leu Arg Lys 
    370                 375                 380                 


Ile Val Asp Lys Glu Lys Ser Lys Gln Thr His Arg Ile Leu Gln Leu 
385                 390                 395                 400 


Asn Cys Cys Ile Gln Cys Leu Asn Ser Ile Ser Arg Ala Tyr Arg Arg 
                405                 410                 415     


Ser Lys Asn Ser Leu Ser Glu Ile Leu Asn Ser Ile Ser Leu Trp Gln 
            420                 425                 430         


Lys Thr Leu Lys Ile Ile Gly Gly Lys Phe Gly Thr Ser Val Leu Ser 
        435                 440                 445             


Tyr Phe Asn Phe Leu Arg Trp Leu Leu Lys Phe Asn Ile Phe Ser Phe 
    450                 455                 460                 


Ile Leu Asn Phe Ser Phe Ile Ile Ile Pro Gln Phe Thr Val Ala Lys 
465                 470                 475                 480 


Lys Asn Thr Leu Gln Phe Thr Gly Leu Glu Phe Phe Thr Gly Val Gly 
                485                 490                 495     


Tyr Phe Arg Asp Thr Val Met Tyr Tyr Gly Phe Tyr Thr Asn Ser Thr 
            500                 505                 510         


Ile Gln His Gly Asn Ser Gly Ala Ser Tyr Asn Met Gln Leu Ala Tyr 
        515                 520                 525             


Ile Phe Thr Ile Gly Ala Cys Leu Thr Thr Cys Phe Phe Ser Leu Leu 
    530                 535                 540                 


Phe Ser Met Ala Lys Tyr Phe Arg Asn Asn Phe Ile Asn Pro His Ile 
545                 550                 555                 560 


Tyr Ser Gly Gly Ile Thr Lys Leu Ile Phe Cys Trp Asp Phe Thr Val 
                565                 570                 575     


Thr His Glu Lys Ala Val Lys Leu Lys Gln Lys Asn Leu Ser Thr Glu 
            580                 585                 590         


Ile Arg Glu Asn Leu Ser Glu Leu Arg Gln Glu Asn Ser Lys Leu Thr 
        595                 600                 605             


Phe Asn Gln Leu Leu Thr Arg Phe Ser Ala Tyr Met Val Ala Trp Val 
    610                 615                 620                 


Val Ser Thr Gly Val Ala Ile Ala Cys Cys Ala Ala Val Tyr Tyr Leu 
625                 630                 635                 640 


Ala Glu Tyr Asn Leu Glu Phe Leu Lys Thr His Ser Asn Pro Gly Ala 
                645                 650                 655     


Val Leu Leu Leu Pro Phe Val Val Ser Cys Ile Asn Leu Ala Val Pro 
            660                 665                 670         


Cys Ile Tyr Ser Met Phe Arg Leu Val Glu Arg Tyr Glu Met Pro Arg 
        675                 680                 685             


His Glu Val Tyr Val Leu Leu Ile Arg Asn Ile Phe Leu Lys Ile Ser 
    690                 695                 700                 


Ile Ile Gly Ile Leu Cys Tyr Tyr Trp Leu Asn Thr Val Ala Leu Ser 
705                 710                 715                 720 


Gly Glu Glu Cys Trp Glu Thr Leu Ile Gly Gln Asp Ile Tyr Arg Leu 
                725                 730                 735     


Leu Leu Met Asp Phe Val Phe Ser Leu Val Asn Ser Phe Leu Gly Glu 
            740                 745                 750         


Phe Leu Arg Arg Ile Ile Gly Met Gln Leu Ile Thr Ser Leu Gly Leu 
        755                 760                 765             


Gln Glu Phe Asp Ile Ala Arg Asn Val Leu Glu Leu Ile Tyr Ala Gln 
    770                 775                 780                 


Thr Leu Val Trp Ile Gly Ile Phe Phe Cys Pro Leu Leu Pro Phe Ile 
785                 790                 795                 800 


Gln Met Ile Met Leu Phe Ile Met Phe Tyr Ser Lys Asn Ile Ser Leu 
                805                 810                 815     


Met Met Asn Phe Gln Pro Pro Ser Lys Ala Trp Arg Ala Ser Gln Met 
            820                 825                 830         


Met Thr Phe Phe Ile Phe Leu Leu Phe Phe Pro Ser Phe Thr Gly Val 
        835                 840                 845             


Leu Cys Thr Leu Ala Ile Thr Ile Trp Arg Leu Lys Pro Ser Ala Asp 
    850                 855                 860                 


Cys Gly Pro Phe Arg Gly Leu Pro Leu Phe Ile His Ser Ile Tyr Ser 
865                 870                 875                 880 


Trp Ile Asp Thr Leu Ser Thr Arg Pro Gly Tyr Leu Trp Val Val Trp 
                885                 890                 895     


Ile Tyr Arg Asn Leu Ile Gly Ser Val His Phe Phe Phe Ile Leu Thr 
            900                 905                 910         


Leu Ile Val Leu Ile Ile Thr Tyr Leu Tyr Trp Gln Ile Thr Glu Gly 
        915                 920                 925             


Arg Lys Ile Met Ile Arg Leu Leu His Glu Gln Ile Ile Asn Glu Gly 
    930                 935                 940                 


Lys Asp Lys Met Phe Leu Ile Glu Lys Leu Ile Lys Leu Gln Asp Met 
945                 950                 955                 960 


Glu Lys Lys Ala Asn Pro Ser Ser Leu Val Leu Glu Arg Arg Glu Val 
                965                 970                 975     


Glu Gln Gln Gly Phe Leu His Leu Gly Glu His Asp Gly Ser Leu Asp 
            980                 985                 990         


Leu Arg Ser Arg Arg Ser Val Gln  Glu Gly Asn Pro Arg  Ala 
        995                 1000                 1005     


<210>  1221
<211>  948
<212>  PRT
<213>  Homo sapiens

<400>  1221

Met Ser Ala Tyr Tyr Arg Asn Asn Trp Ser Glu Glu Asp Pro Asp Tyr 
1               5                   10                  15      


Pro Asp Tyr Ser Gly Ser Gln Asn Arg Thr Gln Gly Tyr Leu Lys Thr 
            20                  25                  30          


Gln Gly Tyr Pro Asp Val Pro Gly Pro Leu Asn Asn Pro Asp Tyr Pro 
        35                  40                  45              


Gly Thr Arg Ser Asn Pro Tyr Ser Val Ala Ser Arg Thr Arg Pro Asp 
    50                  55                  60                  


Tyr Pro Gly Ser Leu Ala Glu Pro Asn Tyr Pro Arg Ser Leu Ser Asn 
65                  70                  75                  80  


Pro Asp Tyr Ser Gly Thr Arg Ser Asn Ala Tyr Ser Ala Ala Ser Arg 
                85                  90                  95      


Thr Ser Pro Asp His Pro Thr Ser Leu Pro Glu Pro Asp Tyr Ser Glu 
            100                 105                 110         


Phe Gln Ser His Pro Tyr His Arg Ala Ser Ser Arg Gln Pro Asp Tyr 
        115                 120                 125             


Pro Gly Ser Gln Arg Asn Pro Asp Phe Ala Gly Ser Ser Ser Ser Gly 
    130                 135                 140                 


Asn Tyr Ala Gly Ser Arg Thr His Pro Asp His Phe Gly Ser Leu Glu 
145                 150                 155                 160 


Pro Asp Tyr Pro Gly Ala Gln Ser Asn Ser Asp His Pro Gly Pro Arg 
                165                 170                 175     


Ala Asn Leu Asn His Pro Gly Ser Arg Lys Asn Leu Glu His Thr Ser 
            180                 185                 190         


Phe Arg Ile Asn Pro Tyr Ala Asp Ser Leu Gly Lys Pro Asp Tyr Pro 
        195                 200                 205             


Gly Ala Asp Ile Gln Pro Asn Ser Pro Pro Phe Phe Gly Glu Pro Asp 
    210                 215                 220                 


Tyr Pro Ser Ala Glu Asp Asn Gln Asn Leu Pro Ser Thr Trp Arg Glu 
225                 230                 235                 240 


Pro Asp Tyr Ser Asp Ala Glu Asn Gly His Asp Tyr Gly Ser Ser Glu 
                245                 250                 255     


Thr Pro Lys Met Thr Arg Gly Val Leu Ser Arg Thr Ser Ser Ile Gln 
            260                 265                 270         


Pro Ser Phe Arg His Arg Ser Asp Asp Pro Val Gly Ser Leu Trp Gly 
        275                 280                 285             


Glu Asn Asp Tyr Pro Glu Gly Ile Glu Met Ala Ser Met Glu Met Ala 
    290                 295                 300                 


Asn Ser Tyr Gly His Ser Leu Pro Gly Ala Pro Gly Ser Gly Tyr Val 
305                 310                 315                 320 


Asn Pro Ala Tyr Val Gly Glu Ser Gly Pro Val His Ala Tyr Gly Asn 
                325                 330                 335     


Pro Pro Leu Ser Glu Cys Asp Trp His Lys Ser Pro Gln Gly Gln Lys 
            340                 345                 350         


Leu Ile Ala Ser Leu Ile Pro Met Thr Ser Arg Asp Arg Ile Lys Ala 
        355                 360                 365             


Ile Arg Asn Gln Pro Arg Thr Met Glu Glu Lys Arg Asn Leu Arg Lys 
    370                 375                 380                 


Ile Val Asp Lys Glu Lys Ser Lys Gln Thr His Arg Ile Leu Gln Leu 
385                 390                 395                 400 


Asn Cys Cys Ile Gln Cys Leu Asn Ser Ile Ser Arg Ala Tyr Arg Arg 
                405                 410                 415     


Ser Lys Asn Ser Leu Ser Glu Ile Leu Asn Ser Ile Ser Leu Trp Gln 
            420                 425                 430         


Lys Thr Leu Lys Ile Ile Gly Gly Lys Phe Gly Thr Ser Val Leu Ser 
        435                 440                 445             


Tyr Phe Asn Phe Leu Arg Trp Leu Leu Lys Phe Asn Ile Phe Ser Phe 
    450                 455                 460                 


Ile Leu Asn Phe Ser Phe Ile Ile Ile Pro Gln Phe Thr Val Ala Lys 
465                 470                 475                 480 


Lys Asn Thr Leu Gln Phe Thr Gly Leu Glu Phe Phe Thr Gly Val Gly 
                485                 490                 495     


Tyr Phe Arg Asp Thr Val Met Tyr Tyr Gly Phe Tyr Thr Asn Ser Thr 
            500                 505                 510         


Ile Gln His Gly Asn Ser Gly Ala Ser Tyr Asn Met Gln Leu Ala Tyr 
        515                 520                 525             


Ile Phe Thr Ile Gly Ala Cys Leu Thr Thr Cys Phe Phe Ser Leu Leu 
    530                 535                 540                 


Phe Ser Met Ala Lys Tyr Phe Arg Asn Asn Phe Ile Asn Pro His Ile 
545                 550                 555                 560 


Tyr Ser Gly Gly Ile Thr Lys Leu Ile Phe Cys Trp Asp Phe Thr Val 
                565                 570                 575     


Thr His Glu Lys Ala Val Lys Leu Lys Gln Lys Asn Leu Ser Thr Glu 
            580                 585                 590         


Ile Arg Glu Asn Leu Ser Glu Leu Arg Gln Glu Asn Ser Lys Leu Thr 
        595                 600                 605             


Phe Asn Gln Leu Leu Thr Arg Phe Ser Ala Tyr Met Val Ala Trp Val 
    610                 615                 620                 


Val Ser Thr Gly Val Ala Ile Ala Cys Cys Ala Ala Val Tyr Tyr Leu 
625                 630                 635                 640 


Ala Glu Tyr Asn Leu Glu Phe Leu Lys Thr His Ser Asn Pro Gly Ala 
                645                 650                 655     


Val Leu Leu Leu Pro Phe Val Val Ser Cys Ile Asn Leu Ala Val Pro 
            660                 665                 670         


Cys Ile Tyr Ser Met Phe Arg Leu Val Glu Arg Tyr Glu Met Pro Arg 
        675                 680                 685             


His Glu Val Tyr Val Leu Leu Ile Arg Asn Ile Phe Leu Lys Ile Ser 
    690                 695                 700                 


Ile Ile Gly Ile Leu Cys Tyr Tyr Trp Leu Asn Thr Val Ala Leu Ser 
705                 710                 715                 720 


Gly Glu Glu Cys Trp Glu Thr Leu Ile Gly Gln Asp Ile Tyr Arg Leu 
                725                 730                 735     


Leu Leu Met Asp Phe Val Phe Ser Leu Val Asn Ser Phe Leu Gly Glu 
            740                 745                 750         


Phe Leu Arg Arg Ile Ile Gly Met Gln Leu Ile Thr Ser Leu Gly Leu 
        755                 760                 765             


Gln Glu Phe Asp Ile Ala Arg Asn Val Leu Glu Leu Ile Tyr Ala Gln 
    770                 775                 780                 


Thr Leu Val Trp Ile Gly Ile Phe Phe Cys Pro Leu Leu Pro Phe Ile 
785                 790                 795                 800 


Gln Met Ile Met Leu Phe Ile Met Phe Tyr Ser Lys Asn Ile Ser Leu 
                805                 810                 815     


Met Met Asn Phe Gln Pro Pro Ser Lys Ala Trp Arg Ala Ser Gln Met 
            820                 825                 830         


Met Thr Phe Phe Ile Phe Leu Leu Phe Phe Pro Ser Phe Thr Gly Val 
        835                 840                 845             


Leu Cys Thr Leu Ala Ile Thr Ile Trp Arg Ile Ile Thr Tyr Leu Tyr 
    850                 855                 860                 


Trp Gln Ile Thr Glu Gly Arg Lys Ile Met Ile Arg Leu Leu His Glu 
865                 870                 875                 880 


Gln Ile Ile Asn Glu Gly Lys Asp Lys Met Phe Leu Ile Glu Lys Leu 
                885                 890                 895     


Ile Lys Leu Gln Asp Met Glu Lys Lys Ala Asn Pro Ser Ser Leu Val 
            900                 905                 910         


Leu Glu Arg Arg Glu Val Glu Gln Gln Gly Phe Leu His Leu Gly Glu 
        915                 920                 925             


His Asp Gly Ser Leu Asp Leu Arg Ser Arg Arg Ser Val Gln Glu Gly 
    930                 935                 940                 


Asn Pro Arg Ala 
945             


<210>  1222
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  1222

Met His Leu Arg Ile His Ala Arg Arg Ser Pro Pro Arg Arg Pro Ala 
1               5                   10                  15      


Trp Thr Leu Gly Ile Trp Phe Leu Phe Trp Gly Cys Ile Val Ser Ser 
            20                  25                  30          


Val Trp Ser Ser Ser Asn Val Ala Ser Ser Ser Ser Thr Ser Ser Ser 
        35                  40                  45              


Pro Gly Ser His Ser Gln His Glu His His Phe His Gly Ser Lys His 
    50                  55                  60                  


His Ser Val Pro Ile Ser Ile Tyr Arg Ser Pro Val Ser Leu Arg Gly 
65                  70                  75                  80  


Gly His Ala Gly Ala Thr Tyr Ile Phe Gly Lys Ser Gly Gly Leu Ile 
                85                  90                  95      


Leu Tyr Thr Trp Pro Ala Asn Asp Arg Pro Ser Thr Arg Ser Asp Arg 
            100                 105                 110         


Leu Ala Val Gly Phe Ser Thr Thr Val Lys Asp Gly Ile Leu Val Arg 
        115                 120                 125             


Ile Asp Ser Ala Pro Gly Leu Gly Asp Phe Leu Gln Leu His Ile Glu 
    130                 135                 140                 


Gln Gly Lys Ile Gly Val Val Phe Asn Ile Gly Thr Val Asp Ile Ser 
145                 150                 155                 160 


Ile Lys Glu Glu Arg Thr Pro Val Asn Asp Gly Lys Tyr His Val Val 
                165                 170                 175     


Arg Phe Thr Arg Asn Gly Gly Asn Ala Thr Leu Gln Val Asp Asn Trp 
            180                 185                 190         


Pro Val Asn Glu His Tyr Pro Thr Gly Asn Thr Asp Asn Glu Arg Phe 
        195                 200                 205             


Gln Met Val Lys Gln Lys Ile Pro Phe Lys Tyr Asn Arg Pro Val Glu 
    210                 215                 220                 


Glu Trp Leu Gln Glu Lys Gly Arg Gln Leu Thr Ile Phe Asn Thr Gln 
225                 230                 235                 240 


Ala Gln Ile Ala Ile Gly Gly Lys Asp Lys Gly Arg Leu Phe Gln Gly 
                245                 250                 255     


Gln Leu Ser Gly Leu Tyr Tyr Asp Gly Leu Lys Val Leu Asn Met Ala 
            260                 265                 270         


Ala Glu Asn Asn Pro Asn Ile Lys Ile Asn Gly Ser Val Arg Leu Val 
        275                 280                 285             


Gly Glu Val Pro Ser Ile Leu Gly Thr Thr Gln Thr Thr Ser Met Pro 
    290                 295                 300                 


Pro Glu Met Ser Thr Thr Val Met Glu Thr Thr Thr Thr Met Ala Thr 
305                 310                 315                 320 


Thr Thr Thr Arg Lys Asn Arg Ser Thr Ala Ser Ile Gln Pro Thr Ser 
                325                 330                 335     


Asp Asp Leu Val Ser Ser Ala Glu Cys Ser Ser Asp Asp Glu Asp Phe 
            340                 345                 350         


Val Glu Cys Glu Pro Ser Thr Ala Asn Pro Thr Glu Pro Gly Ile Arg 
        355                 360                 365             


Arg Val Pro Gly Ala Ser Glu Val Ile Arg Glu Ser Ser Ser Thr Thr 
    370                 375                 380                 


Gly Met Val Val Gly Ile Val Ala Ala Ala Ala Leu Cys Ile Leu Ile 
385                 390                 395                 400 


Leu Leu Tyr Ala Met Tyr Lys Tyr Arg Asn Arg Asp Glu Gly Ser Tyr 
                405                 410                 415     


Gln Val Asp Glu Thr Arg Asn Tyr Ile Ser Asn Ser Ala Gln Ser Asn 
            420                 425                 430         


Gly Thr Leu Met Lys Glu Lys Gln Gln Ser Ser Lys Ser Gly His Lys 
        435                 440                 445             


Lys Gln Lys Asn Lys Asp Arg Glu Tyr Tyr Val 
    450                 455                 


<210>  1223
<211>  859
<212>  PRT
<213>  Homo sapiens

<400>  1223

Met Leu Pro Val Tyr Gln Glu Val Lys Pro Asn Pro Leu Gln Asp Ala 
1               5                   10                  15      


Asn Leu Cys Ser Arg Val Phe Phe Trp Trp Leu Asn Pro Leu Phe Lys 
            20                  25                  30          


Ile Gly His Lys Arg Arg Leu Glu Glu Asp Asp Met Tyr Ser Val Leu 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln His Leu Gly Glu Glu Leu Gln Gly Phe Trp 
    50                  55                  60                  


Asp Lys Glu Val Leu Arg Ala Glu Asn Asp Ala Gln Lys Pro Ser Leu 
65                  70                  75                  80  


Thr Arg Ala Ile Ile Lys Cys Tyr Trp Lys Ser Tyr Leu Val Leu Gly 
                85                  90                  95      


Ile Phe Thr Leu Ile Glu Glu Ser Ala Lys Val Ile Gln Pro Ile Phe 
            100                 105                 110         


Leu Gly Lys Ile Ile Asn Tyr Phe Glu Asn Tyr Asp Pro Met Asp Ser 
        115                 120                 125             


Val Ala Leu Asn Thr Ala Tyr Ala Tyr Ala Thr Val Leu Thr Phe Cys 
    130                 135                 140                 


Thr Leu Ile Leu Ala Ile Leu His His Leu Tyr Phe Tyr His Val Gln 
145                 150                 155                 160 


Cys Ala Gly Met Arg Leu Arg Val Ala Met Cys His Met Ile Tyr Arg 
                165                 170                 175     


Lys Ala Leu Arg Leu Ser Asn Met Ala Met Gly Lys Thr Thr Thr Gly 
            180                 185                 190         


Gln Ile Val Asn Leu Leu Ser Asn Asp Val Asn Lys Phe Asp Gln Val 
        195                 200                 205             


Thr Val Phe Leu His Phe Leu Trp Ala Gly Pro Leu Gln Ala Ile Ala 
    210                 215                 220                 


Val Thr Ala Leu Leu Trp Met Glu Ile Gly Ile Ser Cys Leu Ala Gly 
225                 230                 235                 240 


Met Ala Val Leu Ile Ile Leu Leu Pro Leu Gln Ser Cys Phe Gly Lys 
                245                 250                 255     


Leu Phe Ser Ser Leu Arg Ser Lys Thr Ala Thr Phe Thr Asp Ala Arg 
            260                 265                 270         


Ile Arg Thr Met Asn Glu Val Ile Thr Gly Ile Arg Ile Ile Lys Met 
        275                 280                 285             


Tyr Ala Trp Glu Lys Ser Phe Ser Asn Leu Ile Thr Asn Leu Arg Lys 
    290                 295                 300                 


Lys Glu Ile Ser Lys Ile Leu Arg Ser Ser Cys Leu Arg Gly Met Asn 
305                 310                 315                 320 


Leu Ala Ser Phe Phe Ser Ala Ser Lys Ile Ile Val Phe Val Thr Phe 
                325                 330                 335     


Thr Thr Tyr Val Leu Leu Gly Ser Val Ile Thr Ala Ser Arg Val Phe 
            340                 345                 350         


Val Ala Val Thr Leu Tyr Gly Ala Val Arg Leu Thr Val Thr Leu Phe 
        355                 360                 365             


Phe Pro Ser Ala Ile Glu Arg Val Ser Glu Ala Ile Val Ser Ile Arg 
    370                 375                 380                 


Arg Ile Gln Thr Phe Leu Leu Leu Asp Glu Ile Ser Gln Arg Asn Arg 
385                 390                 395                 400 


Gln Leu Pro Ser Asp Gly Lys Lys Met Val His Val Gln Asp Phe Thr 
                405                 410                 415     


Ala Phe Trp Asp Lys Ala Ser Glu Thr Pro Thr Leu Gln Gly Leu Ser 
            420                 425                 430         


Phe Thr Val Arg Pro Gly Glu Leu Leu Ala Val Val Gly Pro Val Gly 
        435                 440                 445             


Ala Gly Lys Ser Ser Leu Leu Ser Ala Val Leu Gly Glu Leu Ala Pro 
    450                 455                 460                 


Ser His Gly Leu Val Ser Val His Gly Arg Ile Ala Tyr Val Ser Gln 
465                 470                 475                 480 


Gln Pro Trp Val Phe Ser Gly Thr Leu Arg Ser Asn Ile Leu Phe Gly 
                485                 490                 495     


Lys Lys Tyr Glu Lys Glu Arg Tyr Glu Lys Val Ile Lys Ala Cys Ala 
            500                 505                 510         


Leu Lys Lys Asp Leu Gln Leu Leu Glu Asp Gly Asp Leu Thr Val Ile 
        515                 520                 525             


Gly Asp Arg Gly Thr Thr Leu Ser Gly Gly Gln Lys Ala Arg Val Asn 
    530                 535                 540                 


Leu Ala Arg Ala Val Tyr Gln Asp Ala Asp Ile Tyr Leu Leu Asp Asp 
545                 550                 555                 560 


Pro Leu Ser Ala Val Asp Ala Glu Val Ser Arg His Leu Phe Glu Leu 
                565                 570                 575     


Cys Ile Cys Gln Ile Leu His Glu Lys Ile Thr Ile Leu Val Thr His 
            580                 585                 590         


Gln Leu Gln Tyr Leu Lys Ala Ala Ser Gln Ile Leu Ile Leu Lys Asp 
        595                 600                 605             


Gly Lys Met Val Gln Lys Gly Thr Tyr Thr Glu Phe Leu Lys Ser Gly 
    610                 615                 620                 


Ile Asp Phe Gly Ser Leu Leu Lys Lys Asp Asn Glu Glu Ser Glu Gln 
625                 630                 635                 640 


Pro Pro Val Pro Gly Thr Pro Thr Leu Arg Asn Arg Thr Phe Ser Glu 
                645                 650                 655     


Ser Ser Val Trp Ser Gln Gln Ser Ser Arg Pro Ser Leu Lys Asp Gly 
            660                 665                 670         


Ala Leu Glu Ser Gln Asp Thr Glu Asn Val Pro Val Thr Leu Ser Glu 
        675                 680                 685             


Glu Asn Arg Ser Glu Gly Lys Val Gly Phe Gln Ala Tyr Lys Asn Tyr 
    690                 695                 700                 


Phe Arg Ala Gly Ala His Trp Ile Val Phe Ile Phe Leu Ile Leu Leu 
705                 710                 715                 720 


Asn Thr Ala Ala Gln Val Ala Tyr Val Leu Gln Asp Trp Trp Leu Ser 
                725                 730                 735     


Tyr Trp Ala Asn Lys Gln Ser Met Leu Asn Val Thr Val Asn Gly Gly 
            740                 745                 750         


Gly Asn Val Thr Glu Lys Leu Asp Leu Asn Trp Tyr Leu Gly Ile Tyr 
        755                 760                 765             


Ser Gly Leu Thr Val Ala Thr Val Leu Phe Gly Ile Ala Arg Ser Leu 
    770                 775                 780                 


Leu Val Phe Tyr Val Leu Val Asn Ser Ser Gln Thr Leu His Asn Lys 
785                 790                 795                 800 


Met Phe Glu Ser Ile Leu Lys Ala Pro Val Leu Phe Phe Asp Arg Asn 
                805                 810                 815     


Pro Ile Gly Arg Ile Leu Asn Arg Phe Ser Lys Asp Ile Gly His Leu 
            820                 825                 830         


Asp Asp Leu Leu Pro Leu Thr Phe Leu Asp Phe Ile Gln Arg Trp Asp 
        835                 840                 845             


Leu Ala Val Leu Ser Trp Leu Val Ser Asn Ser 
    850                 855                 


<210>  1224
<211>  1149
<212>  PRT
<213>  Homo sapiens

<400>  1224

Met Pro Thr Met Arg Arg Thr Val Ser Glu Ile Arg Ser Arg Ala Glu 
1               5                   10                  15      


Gly Tyr Glu Lys Thr Asp Asp Val Ser Glu Lys Thr Ser Leu Ala Asp 
            20                  25                  30          


Gln Glu Glu Val Arg Thr Ile Phe Ile Asn Gln Pro Gln Leu Thr Lys 
        35                  40                  45              


Phe Cys Asn Asn His Val Ser Thr Ala Lys Tyr Asn Ile Ile Thr Phe 
    50                  55                  60                  


Leu Pro Arg Phe Leu Tyr Ser Gln Phe Arg Arg Ala Ala Asn Ser Phe 
65                  70                  75                  80  


Phe Leu Phe Ile Ala Leu Leu Gln Gln Ile Pro Asp Val Ser Pro Thr 
                85                  90                  95      


Gly Arg Tyr Thr Thr Leu Val Pro Leu Leu Phe Ile Leu Ala Val Ala 
            100                 105                 110         


Ala Ile Lys Glu Ile Ile Glu Asp Ile Lys Arg His Lys Ala Asp Asn 
        115                 120                 125             


Ala Val Asn Lys Lys Gln Thr Gln Val Leu Arg Asn Gly Ala Trp Glu 
    130                 135                 140                 


Ile Val His Trp Glu Lys Val Asn Val Gly Asp Ile Val Ile Ile Lys 
145                 150                 155                 160 


Gly Lys Glu Tyr Ile Pro Ala Asp Thr Val Leu Leu Ser Ser Ser Glu 
                165                 170                 175     


Pro Gln Ala Met Cys Tyr Ile Glu Thr Ser Asn Leu Asp Gly Glu Thr 
            180                 185                 190         


Asn Leu Lys Ile Arg Gln Gly Leu Pro Ala Thr Ser Asp Ile Lys Asp 
        195                 200                 205             


Val Asp Ser Leu Met Arg Ile Ser Gly Arg Ile Glu Cys Glu Ser Pro 
    210                 215                 220                 


Asn Arg His Leu Tyr Asp Phe Val Gly Asn Ile Arg Leu Asp Gly His 
225                 230                 235                 240 


Gly Thr Val Pro Leu Gly Ala Asp Gln Ile Leu Leu Arg Gly Ala Gln 
                245                 250                 255     


Leu Arg Asn Thr Gln Trp Val His Gly Ile Val Val Tyr Thr Gly His 
            260                 265                 270         


Asp Thr Lys Leu Met Gln Asn Ser Thr Ser Pro Pro Leu Lys Leu Ser 
        275                 280                 285             


Asn Val Glu Arg Ile Thr Asn Val Gln Ile Leu Ile Leu Phe Cys Ile 
    290                 295                 300                 


Leu Ile Ala Met Ser Leu Val Cys Ser Val Gly Ser Ala Ile Trp Asn 
305                 310                 315                 320 


Arg Arg His Ser Gly Lys Asp Trp Tyr Leu Asn Leu Asn Tyr Gly Gly 
                325                 330                 335     


Ala Ser Asn Phe Gly Leu Asn Phe Leu Thr Phe Ile Ile Leu Phe Asn 
            340                 345                 350         


Asn Leu Ile Pro Ile Ser Leu Leu Val Thr Leu Glu Val Val Lys Phe 
        355                 360                 365             


Thr Gln Ala Tyr Phe Ile Asn Trp Asp Leu Asp Met His Tyr Glu Pro 
    370                 375                 380                 


Thr Asp Thr Ala Ala Met Ala Arg Thr Ser Asn Leu Asn Glu Glu Leu 
385                 390                 395                 400 


Gly Gln Val Lys Tyr Ile Phe Ser Asp Lys Thr Gly Thr Leu Thr Cys 
                405                 410                 415     


Asn Val Met Gln Phe Lys Lys Cys Thr Ile Ala Gly Val Ala Tyr Gly 
            420                 425                 430         


Gln Asn Ser Gln Phe Gly Asp Glu Lys Thr Phe Ser Asp Ser Ser Leu 
        435                 440                 445             


Leu Glu Asn Leu Gln Asn Asn His Pro Thr Ala Pro Ile Ile Cys Glu 
    450                 455                 460                 


Phe Leu Thr Met Met Ala Val Cys His Thr Ala Val Pro Glu Arg Glu 
465                 470                 475                 480 


Gly Asp Lys Ile Ile Tyr Gln Ala Ala Ser Pro Asp Glu Gly Ala Leu 
                485                 490                 495     


Val Arg Ala Ala Lys Gln Leu Asn Phe Val Phe Thr Gly Arg Thr Pro 
            500                 505                 510         


Asp Ser Val Ile Ile Asp Ser Leu Gly Gln Glu Glu Arg Tyr Glu Leu 
        515                 520                 525             


Leu Asn Val Leu Glu Phe Thr Ser Ala Arg Lys Arg Met Ser Val Ile 
    530                 535                 540                 


Val Arg Thr Pro Ser Gly Lys Leu Arg Leu Tyr Cys Lys Gly Ala Asp 
545                 550                 555                 560 


Thr Val Ile Tyr Asp Arg Leu Ala Glu Thr Ser Lys Tyr Lys Glu Ile 
                565                 570                 575     


Thr Leu Lys His Leu Glu Gln Phe Ala Thr Glu Gly Leu Arg Thr Leu 
            580                 585                 590         


Cys Phe Ala Val Ala Glu Ile Ser Glu Ser Asp Phe Gln Glu Trp Arg 
        595                 600                 605             


Ala Val Tyr Gln Arg Ala Ser Thr Ser Val Gln Asn Arg Leu Leu Lys 
    610                 615                 620                 


Leu Glu Glu Ser Tyr Glu Leu Ile Glu Lys Asn Leu Gln Leu Leu Gly 
625                 630                 635                 640 


Ala Thr Ala Ile Glu Asp Lys Leu Gln Asp Gln Val Pro Glu Thr Ile 
                645                 650                 655     


Glu Thr Leu Met Lys Ala Asp Ile Lys Ile Trp Ile Leu Thr Gly Asp 
            660                 665                 670         


Lys Gln Glu Thr Ala Ile Asn Ile Gly His Ser Cys Lys Leu Leu Lys 
        675                 680                 685             


Lys Asn Met Gly Met Ile Val Ile Asn Glu Gly Ser Leu Asp Gly Thr 
    690                 695                 700                 


Arg Glu Thr Leu Ser Arg His Cys Thr Thr Leu Gly Asp Ala Leu Arg 
705                 710                 715                 720 


Lys Glu Asn Asp Phe Ala Leu Ile Ile Asp Gly Lys Thr Leu Lys Tyr 
                725                 730                 735     


Ala Leu Thr Phe Gly Val Arg Gln Tyr Phe Leu Asp Leu Ala Leu Ser 
            740                 745                 750         


Cys Lys Ala Val Ile Cys Cys Arg Val Ser Pro Leu Gln Lys Ser Glu 
        755                 760                 765             


Val Val Glu Met Val Lys Lys Gln Val Lys Val Val Thr Leu Ala Ile 
    770                 775                 780                 


Gly Asp Gly Ala Asn Asp Val Ser Met Ile Gln Thr Ala His Val Gly 
785                 790                 795                 800 


Val Gly Ile Ser Gly Asn Glu Gly Leu Gln Ala Ala Asn Ser Ser Asp 
                805                 810                 815     


Tyr Ser Ile Ala Gln Phe Lys Tyr Leu Lys Asn Leu Leu Met Ile His 
            820                 825                 830         


Gly Ala Trp Asn Tyr Asn Arg Val Ser Lys Cys Ile Leu Tyr Cys Phe 
        835                 840                 845             


Tyr Lys Asn Ile Val Leu Tyr Ile Ile Glu Ile Trp Phe Ala Phe Val 
    850                 855                 860                 


Asn Gly Phe Ser Gly Gln Ile Leu Phe Glu Arg Trp Cys Ile Gly Leu 
865                 870                 875                 880 


Tyr Asn Val Met Phe Thr Ala Met Pro Pro Leu Thr Leu Gly Ile Phe 
                885                 890                 895     


Glu Arg Ser Cys Arg Lys Glu Asn Met Leu Lys Tyr Pro Glu Leu Tyr 
            900                 905                 910         


Lys Thr Ser Gln Asn Ala Leu Asp Phe Asn Thr Lys Val Phe Trp Val 
        915                 920                 925             


His Cys Leu Asn Gly Leu Phe His Ser Val Ile Leu Phe Trp Phe Pro 
    930                 935                 940                 


Leu Lys Ala Leu Gln Tyr Gly Thr Ala Phe Gly Asn Gly Lys Thr Ser 
945                 950                 955                 960 


Asp Tyr Leu Leu Leu Gly Asn Phe Val Tyr Thr Phe Val Val Ile Thr 
                965                 970                 975     


Val Cys Leu Lys Ala Gly Leu Glu Thr Ser Tyr Trp Thr Trp Phe Ser 
            980                 985                 990         


His Ile Ala Ile Trp Gly Ser Ile  Ala Leu Trp Val Val  Phe Phe Gly 
        995                 1000                 1005             


Ile Tyr  Ser Ser Leu Trp Pro  Ala Ile Pro Met Ala  Pro Asp Met 
    1010                 1015                 1020             


Ser Gly  Glu Ala Ala Met Leu  Phe Ser Ser Gly Val  Phe Trp Met 
    1025                 1030                 1035             


Gly Leu  Leu Phe Ile Pro Val  Ala Ser Leu Leu Leu  Asp Val Val 
    1040                 1045                 1050             


Tyr Lys  Val Ile Lys Arg Thr  Ala Phe Lys Thr Leu  Val Asp Glu 
    1055                 1060                 1065             


Val Gln  Glu Leu Glu Ala Lys  Ser Gln Asp Pro Gly  Ala Val Val 
    1070                 1075                 1080             


Leu Gly  Lys Ser Leu Thr Glu  Arg Ala Gln Leu Leu  Lys Asn Val 
    1085                 1090                 1095             


Phe Lys  Lys Asn His Val Asn  Leu Tyr Arg Ser Glu  Ser Leu Gln 
    1100                 1105                 1110             


Gln Asn  Leu Leu His Gly Tyr  Ala Phe Ser Gln Asp  Glu Asn Gly 
    1115                 1120                 1125             


Ile Val  Ser Gln Ser Glu Val  Ile Arg Ala Tyr Asp  Thr Thr Lys 
    1130                 1135                 1140             


Gln Arg  Pro Asp Glu Trp 
    1145                 


<210>  1225
<211>  783
<212>  PRT
<213>  Homo sapiens

<400>  1225

Met Val Cys Arg Pro Val Phe Pro Cys Arg Arg Arg Phe Cys Pro Arg 
1               5                   10                  15      


Pro Phe Leu Val Gly Leu Val Val Ala Ile Cys Leu Phe Tyr Gln Thr 
            20                  25                  30          


Leu Thr Leu Arg Gly Ser Arg Lys Leu Thr Ala Ala Ala Pro Gly Ala 
        35                  40                  45              


Val Pro His Thr Ser Thr Glu Thr Gln Ala Ser Arg Cys Lys Lys Gly 
    50                  55                  60                  


Phe Ser Gln Asp Lys Gln Cys Phe Leu Leu Ser Gly Asn Ala Gln Glu 
65                  70                  75                  80  


Thr Arg Lys Val Lys Glu Ser Met Glu Thr His Phe Gly Ser His Gly 
                85                  90                  95      


Arg Arg Ala Ile Leu Tyr Arg Pro Pro Phe Tyr Ser Lys Thr Glu Leu 
            100                 105                 110         


Gln Leu His Gln His Ile Leu Thr Gln His Gly Tyr Thr Val Val Ile 
        115                 120                 125             


Ala Glu Glu Arg Leu Asn Ala Gly Leu Gly Pro Gly Leu Leu Glu Gln 
    130                 135                 140                 


Gly Asp Leu Gly Ser Trp Asp Leu Leu Ile Cys Leu Ser Ser Lys Lys 
145                 150                 155                 160 


Ala Glu Gly Thr Pro Cys Ile Ser Lys Glu Val Met Cys Gln Leu Gly 
                165                 170                 175     


Leu His Gln Lys Ala Asn Arg Leu Pro Glu Ile Gln Gln Pro Leu Cys 
            180                 185                 190         


Arg Lys Glu Gly Leu Cys Gln Ile Val Arg Arg Phe Pro Glu Leu Gln 
        195                 200                 205             


Leu Pro Val Ser Pro Ser Val Cys Leu Asp Gln Gly Met Gln Leu Lys 
    210                 215                 220                 


Pro Ser Thr Ser Ser His Leu Leu Lys Thr Val Lys Pro Arg Val Trp 
225                 230                 235                 240 


Lys Pro Gly Asp Trp Ser Arg Glu Gln Leu Asn Glu Thr Thr Val Leu 
                245                 250                 255     


Ala Pro His Glu Thr Ile Phe Arg Ala Glu Asp Leu Ser Val Ile Leu 
            260                 265                 270         


Lys Ala Tyr Val Leu Val Thr Ser Leu Thr Pro Leu Arg Ala Phe Ile 
        275                 280                 285             


His Ser Thr Gly Thr Val Trp Asn Pro Pro Lys Lys Lys Arg Phe Thr 
    290                 295                 300                 


Val Lys Leu Gln Thr Phe Phe Glu Thr Phe Leu Arg Ala Ser Ser Pro 
305                 310                 315                 320 


Gln Gln Ala Phe Asp Ile Met Lys Glu Ala Ile Gly Lys Leu Leu Leu 
                325                 330                 335     


Ala Ala Glu Val Phe Ser Glu Thr Ser Thr Leu Gly Pro Lys Thr Phe 
            340                 345                 350         


His Arg Cys Arg Phe Cys Phe Gln Leu Leu Thr Phe Asp Ile Gly Tyr 
        355                 360                 365             


Gly Ser Phe Met Tyr Pro Val Val Leu Gln Val His Glu His Leu Asn 
    370                 375                 380                 


Phe Gln Asp Tyr Asp Asn Met Asp Phe Glu Asp Gln Asn Thr Glu Glu 
385                 390                 395                 400 


Phe Leu Leu Asn Asp Thr Phe Asn Phe Leu Phe Pro Asn Glu Ser Ser 
                405                 410                 415     


Leu Ser Ile Phe Ser Glu Ile Phe Gln Arg Leu Tyr Arg Ser Asp Val 
            420                 425                 430         


Phe Lys Gly Glu Asn Tyr Gln Lys Glu Leu Asn Gln Cys Leu Ser Leu 
        435                 440                 445             


Glu Glu Ile Asn Ser Ile Met Thr Phe Ile Lys Glu Leu Gly Ser Leu 
    450                 455                 460                 


Gly Gln Phe Gln Leu Leu Phe Pro Ser Thr Thr Pro Gly Ile Gln Ser 
465                 470                 475                 480 


Leu Met His Glu Phe Tyr Asp Val Ala Asn Pro Val Gly Asn Pro Gly 
                485                 490                 495     


Ser Val Leu Thr Gln Tyr Trp Ser Leu Leu Asn Val Phe Glu Gln Phe 
            500                 505                 510         


Gln Phe Met Asn Lys Lys Thr Gln Pro His Pro Leu Glu Trp Asn Ser 
        515                 520                 525             


Phe Thr Glu Asp Lys Asn Ile Glu Lys Pro Gln Val Pro Phe Asp Ala 
    530                 535                 540                 


Ile Glu Asn Lys Lys Ala Ala Val Pro Gln Ile Lys Asn Glu Asn Lys 
545                 550                 555                 560 


Glu Ile His Cys Ser Asp Asp Glu Asn Thr Pro Cys His Ile Lys Gln 
                565                 570                 575     


Ile Phe Thr His Pro His Leu Glu Leu Asn Pro Asp Phe His Pro Lys 
            580                 585                 590         


Ile Lys Asp Tyr Tyr Cys Glu Val Pro Phe Asp Val Val Thr Val Thr 
        595                 600                 605             


Ile Gly Val Glu Thr Pro Lys Cys Leu Cys Lys Val His Leu Tyr Glu 
    610                 615                 620                 


Gln Ala Gly Pro Ser Phe Ala Ser Tyr Pro Leu Gly Leu Gly Met Asn 
625                 630                 635                 640 


Lys Ile Ser Ile Phe Val Val Asp Glu Ser Pro Ala His Gly Glu Thr 
                645                 650                 655     


Leu Ile Thr Tyr Lys Leu Thr Ile Tyr Arg Glu Asp Arg Pro Ser Leu 
            660                 665                 670         


Pro Leu Phe Glu Ala Phe Thr Ala Cys Gly Phe Val Gln Asp Cys Gly 
        675                 680                 685             


Leu Leu Ile His Pro Glu Glu Thr Cys Gly Leu Gln Pro Ile Ser Ser 
    690                 695                 700                 


Asp Tyr Ile Glu Ala Ile Leu Gln Ser Glu Leu Lys Arg Cys Pro Ser 
705                 710                 715                 720 


Gly Asp Met Lys Gly Gln Trp Ile Val Pro Cys Leu Ser Cys Ser Asp 
                725                 730                 735     


Asn Arg Thr Cys Asp Trp Arg Glu Ile Thr Trp Gln Pro His Asn Cys 
            740                 745                 750         


Gln Tyr Gly Val Leu Thr Lys Pro Gln Leu Gln Gln Cys Leu Gly Gly 
        755                 760                 765             


Arg Lys Leu Gly Val Asp Val Gln Arg Val Pro Arg Ser Arg Asn 
    770                 775                 780             


<210>  1226
<211>  492
<212>  PRT
<213>  Homo sapiens

<400>  1226

Met Lys Ala Met Pro Trp Asn Trp Thr Cys Leu Leu Ser His Leu Leu 
1               5                   10                  15      


Met Val Gly Met Gly Ser Ser Thr Leu Leu Thr Arg Gln Pro Ala Pro 
            20                  25                  30          


Leu Ser Gln Lys Gln Arg Ser Phe Val Thr Phe Arg Gly Glu Pro Ala 
        35                  40                  45              


Glu Gly Phe Asn His Leu Val Val Asp Glu Arg Thr Gly His Ile Tyr 
    50                  55                  60                  


Leu Gly Ala Val Asn Arg Ile Tyr Lys Leu Ser Ser Asp Leu Lys Val 
65                  70                  75                  80  


Leu Val Thr His Glu Thr Gly Pro Asp Glu Asp Asn Pro Lys Cys Tyr 
                85                  90                  95      


Pro Pro Arg Ile Val Gln Thr Cys Asn Glu Pro Leu Thr Thr Thr Asn 
            100                 105                 110         


Asn Val Asn Lys Met Leu Leu Ile Asp Tyr Lys Glu Asn Arg Leu Ile 
        115                 120                 125             


Ala Cys Gly Ser Leu Tyr Gln Gly Ile Cys Lys Leu Leu Arg Leu Glu 
    130                 135                 140                 


Asp Leu Phe Lys Leu Gly Glu Pro Tyr His Lys Lys Glu His Tyr Leu 
145                 150                 155                 160 


Ser Gly Val Asn Glu Ser Gly Ser Val Phe Gly Val Ile Val Ser Tyr 
                165                 170                 175     


Ser Asn Leu Asp Asp Lys Leu Phe Ile Ala Thr Ala Val Asp Gly Lys 
            180                 185                 190         


Pro Glu Tyr Phe Pro Thr Ile Ser Ser Arg Lys Leu Thr Lys Asn Ser 
        195                 200                 205             


Glu Ala Asp Gly Met Phe Ala Tyr Val Phe His Asp Glu Phe Val Ala 
    210                 215                 220                 


Ser Met Ile Lys Ile Pro Ser Asp Thr Phe Thr Ile Ile Pro Asp Phe 
225                 230                 235                 240 


Asp Ile Tyr Tyr Val Tyr Gly Phe Ser Ser Gly Asn Phe Val Tyr Phe 
                245                 250                 255     


Leu Thr Leu Gln Pro Glu Met Val Ser Pro Pro Gly Ser Thr Thr Lys 
            260                 265                 270         


Glu Gln Val Tyr Thr Ser Lys Leu Val Arg Leu Cys Lys Glu Asp Thr 
        275                 280                 285             


Ala Phe Asn Ser Tyr Val Glu Val Pro Ile Gly Cys Glu Arg Ser Gly 
    290                 295                 300                 


Val Glu Tyr Arg Leu Leu Gln Ala Ala Tyr Leu Ser Lys Ala Gly Ala 
305                 310                 315                 320 


Val Leu Gly Arg Thr Leu Gly Val His Pro Asp Asp Asp Leu Leu Phe 
                325                 330                 335     


Thr Val Phe Ser Lys Gly Gln Lys Arg Lys Met Lys Ser Leu Asp Glu 
            340                 345                 350         


Ser Ala Leu Cys Ile Phe Ile Leu Lys Gln Ile Asn Asp Arg Ile Lys 
        355                 360                 365             


Glu Arg Leu Gln Ser Cys Tyr Arg Gly Glu Gly Thr Leu Asp Leu Ala 
    370                 375                 380                 


Trp Leu Lys Val Lys Asp Ile Pro Cys Ser Ser Ala Leu Leu Thr Ile 
385                 390                 395                 400 


Asp Asp Asn Phe Cys Gly Leu Asp Met Asn Ala Pro Leu Gly Val Ser 
                405                 410                 415     


Asp Met Val Arg Gly Ile Pro Val Phe Thr Glu Asp Arg Asp Arg Met 
            420                 425                 430         


Thr Ser Val Ile Ala Tyr Val Tyr Lys Asn His Ser Leu Ala Phe Val 
        435                 440                 445             


Gly Thr Lys Ser Gly Lys Leu Lys Lys Met Pro Gly Thr Ser Leu Cys 
    450                 455                 460                 


Pro Thr Leu Glu Leu Gln Thr Gly Pro Arg Ser His Arg Ala Thr Val 
465                 470                 475                 480 


Thr Leu Glu Leu Leu Phe Ser Ser Cys Ser Ser Asn 
                485                 490         


<210>  1227
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  1227

Met Met Leu Gln Leu Leu Glu Lys Val Ile Glu Leu Glu Asn Trp Thr 
1               5                   10                  15      


Glu Gly Lys Gly Leu Ile Val Arg Gly Ala Lys Asn Thr Phe Ser Ser 
            20                  25                  30          


Gly Ser Asp Leu Asn Ala Val Lys Ser Leu Gly Thr Pro Glu Asp Gly 
        35                  40                  45              


Met Ala Val Cys Met Phe Met Gln Asn Thr Leu Thr Arg Phe Met Arg 
    50                  55                  60                  


Leu Pro Leu Ile Ser Val Ala Leu Val Gln Gly Trp Ala Leu Gly Gly 
65                  70                  75                  80  


Gly Ala Glu Phe Thr Thr Ala Cys Asp Phe Arg Leu Met Thr Pro Glu 
                85                  90                  95      


Ser Lys Ile Arg Phe Val His Lys Glu Met Gly Ile Ile Pro Ser Trp 
            100                 105                 110         


Gly Gly Thr Thr Arg Leu Val Glu Ile Ile Gly Ser Arg Gln Ala Leu 
        115                 120                 125             


Lys Val Leu Ser Gly Ala Leu Lys Leu Asp Ser Lys Asn Ala Leu Asn 
    130                 135                 140                 


Ile Gly Met Val Glu Glu Val Leu Gln Ser Ser Asp Glu Thr Lys Ser 
145                 150                 155                 160 


Leu Glu Glu Ala Gln Glu Trp Leu Lys Gln Phe Ile Gln Gly Pro Pro 
                165                 170                 175     


Glu Val Ile Arg Ala Leu Lys Lys Ser Val Cys Ser Gly Arg Glu Leu 
            180                 185                 190         


Tyr Leu Glu Glu Ala Leu Gln Asn Glu Arg Asp Leu Leu Gly Thr Val 
        195                 200                 205             


Trp Gly Gly Pro Ala Asn Leu Glu Ala Ile Ala Lys Lys Gly Lys Phe 
    210                 215                 220                 


Asn Lys 
225     


<210>  1228
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  1228

Met Met Leu Gln Leu Leu Glu Lys Val Ile Glu Leu Glu Asn Trp Thr 
1               5                   10                  15      


Glu Gly Lys Gly Leu Ile Val Arg Gly Ala Lys Asn Thr Phe Ser Ser 
            20                  25                  30          


Gly Ser Asp Leu Asn Ala Val Lys Ser Leu Gly Thr Pro Glu Thr Ser 
        35                  40                  45              


Phe Asn Lys Cys Cys Ala Gly Ser Arg Leu Gly Ile Gly Trp Arg Ser 
    50                  55                  60                  


Arg Ile Tyr Tyr Ser Met 
65                  70  


<210>  1229
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  1229

Met Gly Val Met Ala Met Leu Met Leu Pro Leu Leu Leu Leu Gly Ile 
1               5                   10                  15      


Ser Gly Leu Leu Phe Ile Tyr Gln Glu Val Ser Arg Leu Trp Ser Lys 
            20                  25                  30          


Ser Ala Val Gln Asn Lys Val Val Val Ile Thr Asp Ala Ile Ser Gly 
        35                  40                  45              


Leu Gly Lys Glu Cys Ala Arg Val Phe His Thr Gly Gly Ala Arg Leu 
    50                  55                  60                  


Val Leu Cys Gly Lys Asn Trp Glu Arg Leu Glu Asn Leu Tyr Asp Ala 
65                  70                  75                  80  


Leu Ile Ser Val Ala Asp Pro Ser Lys Thr Phe Thr Pro Lys Leu Val 
                85                  90                  95      


Leu Leu Asp Leu Ser Asp Ile Ser Cys Val Pro Asp Val Ala Lys Glu 
            100                 105                 110         


Val Leu Asp Cys Tyr Gly Cys Val Asp Ile Leu Ile Asn Asn Ala Ser 
        115                 120                 125             


Val Lys Val Lys Gly Pro Ala His Lys Ile Ser Leu Glu Leu Asp Lys 
    130                 135                 140                 


Lys Ile Met Asp Ala Asn Tyr Phe Gly Pro Ile Thr Leu Thr Lys Ala 
145                 150                 155                 160 


Leu Leu Pro Asn Met Ile Ser Arg Arg Thr Gly Gln Ile Val Leu Val 
                165                 170                 175     


Asn Asn Ile Gln Gly Lys Phe Gly Ile Pro Phe Arg Thr Thr Tyr Ala 
            180                 185                 190         


Ala Ser Lys His Ala Ala Leu Gly Phe Phe Asp Cys Leu Arg Ala Glu 
        195                 200                 205             


Val Glu Glu Tyr Asp Val Val Ile Ser Thr Val Ser Pro Thr Phe Ile 
    210                 215                 220                 


Arg Ser Tyr His Val Tyr Pro Glu Gln Gly Asn Trp Glu Ala Ser Ile 
225                 230                 235                 240 


Trp Lys Phe Phe Phe Arg Lys Leu Thr Tyr Gly Val His Pro Val Glu 
                245                 250                 255     


Val Ala Glu Glu Val Met Arg Thr Val Arg Arg Lys Lys Gln Glu Val 
            260                 265                 270         


Phe Met Ala Asn Pro Ile Pro Lys Ala Ala Val Tyr Val Arg Thr Phe 
        275                 280                 285             


Phe Pro Glu Phe Phe Phe Ala Val Val Ala Cys Gly Val Lys Glu Lys 
    290                 295                 300                 


Leu Asn Val Pro Glu Glu Gly 
305                 310     


<210>  1230
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  1230

Met Glu Ser Leu Ser Glu Leu Gln Asn Pro Leu Leu Pro Arg Ser Pro 
1               5                   10                  15      


Ala His Leu His Gly Pro Tyr Pro Tyr Pro Glu Thr Pro Pro Ser Trp 
            20                  25                  30          


Ser Cys Gln Glu Lys Leu Tyr Ser Tyr Leu Leu Gly Gly Ala Gly Pro 
        35                  40                  45              


Ala Gly Ala His Gln Leu Leu Asp Pro Gly Ser Leu Gln Leu Ala Val 
    50                  55                  60                  


Glu Ala Trp Tyr Arg Pro Ser Cys Leu Leu Gly Arg Asp Lys Val Lys 
65                  70                  75                  80  


Glu Pro Arg Ala Gly Ser Cys Glu Thr Ser Phe Thr Glu Asp Arg Glu 
                85                  90                  95      


Pro Gln Glu Gly Pro Pro Glu Gln Pro Thr Gly Pro Gly Gln Ala Ala 
            100                 105                 110         


Glu Asn Val Thr Ile Gln Thr Val Ser Tyr Gly Val Gln Glu Glu Leu 
        115                 120                 125             


Arg Asp Gln Glu Asp Asp Gln Glu Glu Glu Glu Ser Asp Ala Thr Ser 
    130                 135                 140                 


Thr Glu Ser Glu Ser Glu Asp Asn Phe Leu Thr Leu Pro Pro Arg Asp 
145                 150                 155                 160 


His Leu Gly Leu Thr Leu Phe Ser Met Leu Cys Cys Phe Trp Pro Leu 
                165                 170                 175     


Gly Ile Ala Ala Phe Tyr Phe Ser Gln Gly Thr Ser Lys Ala Ile Ser 
            180                 185                 190         


Lys Gly Asp Phe Arg Leu Ala Ser Thr Thr Ser Arg Arg Ala Leu Phe 
        195                 200                 205             


Leu Ala Thr Leu Ala Ile Ala Val Gly Ala Gly Leu Tyr Val Ala Val 
    210                 215                 220                 


Val Val Ala Leu Ala Ala Tyr Met Ser Gln Asn Gly His Gly 
225                 230                 235             


<210>  1231
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  1231

Met Val Leu Ala Phe Gln Leu Val Ser Phe Thr Tyr Ile Trp Ile Ile 
1               5                   10                  15      


Leu Lys Pro Asn Val Cys Ala Ala Ser Asn Ile Lys Met Thr His Gln 
            20                  25                  30          


Arg Cys Ser Ser Ser Met Lys Gln Thr Cys Lys Gln Glu Thr Arg Met 
        35                  40                  45              


Lys Lys Asp Asp Ser Thr Lys Ala Arg Pro Gln Lys Tyr Glu Gln Leu 
    50                  55                  60                  


Leu His Ile Glu Asp Asn Asp Phe Ala Met Arg Pro Gly Phe Gly Gly 
65                  70                  75                  80  


Ser Pro Val Pro Val Gly Ile Asp Val His Val Glu Ser Ile Asp Ser 
                85                  90                  95      


Ile Ser Glu Thr Asn Met Asp Phe Thr Met Thr Phe Tyr Leu Arg His 
            100                 105                 110         


Tyr Trp Lys Asp Glu Arg Leu Ser Phe Pro Ser Thr Ala Asn Lys Ser 
        115                 120                 125             


Met Thr Phe Asp His Arg Leu Thr Arg Lys Ile Trp Val Pro Asp Ile 
    130                 135                 140                 


Phe Phe Val His Ser Lys Arg Ser Phe Ile His Asp Thr Thr Met Glu 
145                 150                 155                 160 


Asn Ile Met Leu Arg Val His Pro Asp Gly Asn Val Leu Leu Ser Leu 
                165                 170                 175     


Arg Ile Thr Val Ser Ala Met Cys Phe Met Asp Phe Ser Arg Phe Pro 
            180                 185                 190         


Leu Asp Thr Gln Asn Cys Ser Leu Glu Leu Glu Ser Tyr Ala Tyr Asn 
        195                 200                 205             


Glu Asp Asp Leu Met Leu Tyr Trp Lys His Gly Asn Lys Ser Leu Asn 
    210                 215                 220                 


Thr Glu Glu His Met Ser Leu Ser Gln Phe Phe Ile Glu Asp Phe Ser 
225                 230                 235                 240 


Ala Ser Ser Gly Leu Ala Phe Tyr Ser Ser Thr Gly Trp Tyr Asn Arg 
                245                 250                 255     


Leu Phe Ile Asn Phe Val Leu Arg Arg His Val Phe Phe Phe Val Leu 
            260                 265                 270         


Gln Thr Tyr Phe Pro Ala Ile Leu Met Val Met Leu Ser Trp Val Ser 
        275                 280                 285             


Phe Trp Ile Asp Arg Arg Ala Val Pro Ala Arg Val Ser Leu Gly Ile 
    290                 295                 300                 


Thr Thr Val Leu Thr Met Ser Thr Ile Ile Thr Ala Val Ser Ala Ser 
305                 310                 315                 320 


Met Pro Gln Val Ser Tyr Leu Lys Ala Val Asp Val Tyr Leu Trp Val 
                325                 330                 335     


Ser Ser Leu Phe Val Phe Leu Ser Val Ile Glu Tyr Ala Ala Val Asn 
            340                 345                 350         


Tyr Leu Thr Thr Val Glu Glu Arg Lys Gln Phe Lys Lys Thr Gly Lys 
        355                 360                 365             


Ile Ser Arg Met Tyr Asn Ile Asp Ala Val Gln Ala Met Ala Phe Asp 
    370                 375                 380                 


Gly Cys Tyr His Asp Ser Glu Ile Asp Met Asp Gln Thr Ser Leu Ser 
385                 390                 395                 400 


Leu Asn Ser Glu Asp Phe Met Arg Arg Lys Ser Ile Cys Ser Pro Ser 
                405                 410                 415     


Thr Asp Ser Ser Arg Ile Lys Arg Arg Lys Ser Leu Gly Gly His Val 
            420                 425                 430         


Gly Arg Ile Ile Leu Glu Asn Asn His Val Ile Asp Thr Tyr Ser Arg 
        435                 440                 445             


Ile Leu Phe Pro Ile Val Tyr Ile Leu Phe Asn Leu Phe Tyr Trp Gly 
    450                 455                 460                 


Val Tyr Val 
465         


<210>  1232
<211>  824
<212>  PRT
<213>  Homo sapiens

<400>  1232

Met Arg Gly Leu Gly Leu Trp Leu Leu Gly Ala Met Met Leu Pro Ala 
1               5                   10                  15      


Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val Val 
            20                  25                  30          


Leu Pro Trp Arg Leu Pro Gly Pro Arg Val Arg Arg Ala Leu Pro Ser 
        35                  40                  45              


His Leu Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala Thr 
    50                  55                  60                  


Gly His Asn Phe Thr Leu His Leu Arg Lys Asn Arg Asp Leu Leu Gly 
65                  70                  75                  80  


Ser Gly Tyr Thr Glu Thr Tyr Thr Ala Ala Asn Gly Ser Glu Val Thr 
                85                  90                  95      


Glu Gln Pro Arg Gly Gln Asp His Cys Phe Tyr Gln Gly His Val Glu 
            100                 105                 110         


Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Thr Cys Ala Gly Leu Arg 
        115                 120                 125             


Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu Asp 
    130                 135                 140                 


Glu Gly Gly Glu Gly Gly Arg His Ala Val Tyr Gln Ala Glu His Leu 
145                 150                 155                 160 


Leu Gln Thr Ala Gly Thr Cys Gly Val Ser Asp Asp Ser Leu Gly Ser 
                165                 170                 175     


Leu Leu Gly Pro Arg Thr Ala Ala Val Phe Arg Pro Arg Pro Gly Asp 
            180                 185                 190         


Ser Leu Pro Ser Arg Glu Thr Arg Tyr Val Glu Leu Tyr Val Val Val 
        195                 200                 205             


Asp Asn Ala Glu Phe Gln Met Leu Gly Ser Glu Ala Ala Val Arg His 
    210                 215                 220                 


Arg Val Leu Glu Val Val Asn His Val Asp Lys Leu Tyr Gln Lys Leu 
225                 230                 235                 240 


Asn Phe Arg Val Val Leu Val Gly Leu Glu Ile Trp Asn Ser Gln Asp 
                245                 250                 255     


Arg Phe His Val Ser Pro Asp Pro Ser Val Thr Leu Glu Asn Leu Leu 
            260                 265                 270         


Thr Trp Gln Ala Arg Gln Arg Thr Arg Arg His Leu His Asp Asn Val 
        275                 280                 285             


Gln Leu Ile Thr Gly Val Asp Phe Thr Gly Thr Thr Val Gly Phe Ala 
    290                 295                 300                 


Arg Val Ser Ala Met Cys Ser His Ser Ser Gly Ala Val Asn Gln Asp 
305                 310                 315                 320 


His Ser Lys Asn Pro Val Gly Val Ala Cys Thr Met Ala His Glu Met 
                325                 330                 335     


Gly His Asn Leu Gly Met Asp His Asp Glu Asn Val Gln Gly Cys Arg 
            340                 345                 350         


Cys Gln Glu Arg Phe Glu Ala Gly Arg Cys Ile Met Ala Gly Ser Ile 
        355                 360                 365             


Gly Ser Ser Phe Pro Arg Met Phe Ser Asp Cys Ser Gln Ala Tyr Leu 
    370                 375                 380                 


Glu Ser Phe Leu Glu Arg Pro Gln Ser Val Cys Leu Ala Asn Ala Pro 
385                 390                 395                 400 


Asp Leu Ser His Leu Val Gly Gly Pro Val Cys Gly Asn Leu Phe Val 
                405                 410                 415     


Glu Arg Gly Glu Gln Cys Asp Cys Gly Pro Pro Glu Asp Cys Arg Asn 
            420                 425                 430         


Arg Cys Cys Asn Ser Thr Thr Cys Gln Leu Ala Glu Gly Ala Gln Cys 
        435                 440                 445             


Ala His Gly Thr Cys Cys Gln Glu Cys Lys Val Lys Pro Ala Gly Glu 
    450                 455                 460                 


Leu Cys Arg Pro Lys Lys Asp Met Cys Asp Leu Glu Glu Phe Cys Asp 
465                 470                 475                 480 


Gly Arg His Pro Glu Cys Pro Glu Asp Ala Phe Gln Glu Asn Gly Thr 
                485                 490                 495     


Pro Cys Ser Gly Gly Tyr Cys Tyr Asn Gly Ala Cys Pro Thr Leu Ala 
            500                 505                 510         


Gln Gln Cys Gln Ala Phe Trp Gly Pro Gly Gly Gln Ala Ala Glu Glu 
        515                 520                 525             


Ser Cys Phe Ser Tyr Asp Ile Leu Pro Gly Cys Lys Ala Ser Arg Tyr 
    530                 535                 540                 


Arg Ala Asp Met Cys Gly Val Leu Gln Cys Lys Gly Gly Gln Gln Pro 
545                 550                 555                 560 


Leu Gly Arg Ala Ile Cys Ile Val Asp Val Cys His Ala Leu Thr Thr 
                565                 570                 575     


Glu Asp Gly Thr Ala Tyr Glu Pro Val Pro Glu Gly Thr Arg Cys Gly 
            580                 585                 590         


Pro Glu Lys Val Cys Trp Lys Gly Arg Cys Gln Asp Leu His Val Tyr 
        595                 600                 605             


Arg Ser Ser Asn Cys Ser Ala Gln Cys His Asn His Gly Val Cys Asn 
    610                 615                 620                 


His Lys Gln Glu Cys His Cys His Ala Gly Trp Ala Pro Pro His Cys 
625                 630                 635                 640 


Ala Lys Leu Leu Thr Glu Val His Ala Ala Ser Gly Ser Leu Pro Val 
                645                 650                 655     


Phe Val Val Val Val Leu Val Leu Leu Ala Val Val Leu Val Thr Leu 
            660                 665                 670         


Ala Gly Ile Ile Val Tyr Arg Lys Ala Arg Ser Arg Ile Leu Ser Arg 
        675                 680                 685             


Asn Val Ala Pro Lys Thr Thr Met Gly Arg Ser Asn Pro Leu Phe His 
    690                 695                 700                 


Gln Ala Ala Ser Arg Val Pro Ala Lys Gly Gly Ala Pro Ala Pro Ser 
705                 710                 715                 720 


Arg Gly Pro Gln Glu Leu Val Pro Thr Thr His Pro Gly Gln Pro Ala 
                725                 730                 735     


Arg His Pro Ala Ser Ser Val Ala Leu Lys Arg Pro Pro Pro Ala Pro 
            740                 745                 750         


Pro Val Thr Val Ser Ser Pro Pro Phe Pro Val Pro Val Tyr Thr Arg 
        755                 760                 765             


Gln Ala Pro Lys Gln Val Ile Lys Pro Thr Phe Ala Pro Pro Val Pro 
    770                 775                 780                 


Pro Val Lys Pro Gly Ala Gly Ala Ala Asn Pro Gly Pro Ala Glu Gly 
785                 790                 795                 800 


Ala Val Gly Pro Lys Val Ala Leu Lys Pro Pro Ile Gln Arg Lys Gln 
                805                 810                 815     


Gly Ala Gly Ala Pro Thr Ala Pro 
            820                 


<210>  1233
<211>  748
<212>  PRT
<213>  Homo sapiens

<400>  1233

Met Val Leu Leu Arg Val Leu Ile Leu Leu Leu Ser Trp Ala Ala Gly 
1               5                   10                  15      


Met Gly Gly Gln Tyr Gly Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr 
            20                  25                  30          


Glu Gly Leu Ser Tyr Asn Val Asp Ser Leu His Gln Lys His Gln Arg 
        35                  40                  45              


Ala Lys Arg Ala Val Ser His Glu Asp Gln Phe Leu Arg Leu Asp Phe 
    50                  55                  60                  


His Ala His Gly Arg His Phe Asn Leu Arg Met Lys Arg Asp Thr Ser 
65                  70                  75                  80  


Leu Phe Ser Asp Glu Phe Lys Val Glu Thr Ser Asn Lys Val Leu Asp 
                85                  90                  95      


Tyr Asp Thr Ser His Ile Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly 
            100                 105                 110         


Ser Phe Ser His Gly Ser Val Ile Asp Gly Arg Phe Glu Gly Phe Ile 
        115                 120                 125             


Gln Thr Arg Gly Gly Thr Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile 
    130                 135                 140                 


Lys Asp Arg Thr Leu Pro Phe His Ser Val Ile Tyr His Glu Asp Asp 
145                 150                 155                 160 


Ile Asn Tyr Pro His Lys Tyr Gly Pro Gln Gly Gly Cys Ala Asp His 
                165                 170                 175     


Ser Val Phe Glu Arg Met Arg Lys Tyr Gln Met Thr Gly Val Glu Glu 
            180                 185                 190         


Val Thr Gln Ile Pro Gln Glu Glu His Ala Ala Asn Gly Pro Glu Leu 
        195                 200                 205             


Leu Arg Lys Lys Arg Thr Thr Ser Ala Glu Lys Asn Thr Cys Gln Leu 
    210                 215                 220                 


Tyr Ile Gln Thr Asp His Leu Phe Phe Lys Tyr Tyr Gly Thr Arg Glu 
225                 230                 235                 240 


Ala Val Ile Ala Gln Ile Ser Ser His Val Lys Ala Ile Asp Thr Ile 
                245                 250                 255     


Tyr Gln Thr Thr Asp Phe Ser Gly Ile Arg Asn Ile Ser Phe Met Val 
            260                 265                 270         


Lys Arg Ile Arg Ile Asn Thr Thr Ala Asp Glu Lys Asp Pro Thr Asn 
        275                 280                 285             


Pro Phe Arg Phe Pro Asn Ile Gly Val Glu Lys Phe Leu Glu Leu Asn 
    290                 295                 300                 


Ser Glu Gln Asn His Asp Asp Tyr Cys Leu Ala Tyr Val Phe Thr Asp 
305                 310                 315                 320 


Arg Asp Phe Asp Asp Gly Val Leu Gly Leu Ala Trp Val Gly Ala Pro 
                325                 330                 335     


Ser Gly Ser Ser Gly Gly Ile Cys Glu Lys Ser Lys Leu Tyr Ser Asp 
            340                 345                 350         


Gly Lys Lys Lys Ser Leu Asn Thr Gly Ile Ile Thr Val Gln Asn Tyr 
        355                 360                 365             


Gly Ser His Val Pro Pro Lys Val Ser His Ile Thr Phe Ala His Glu 
    370                 375                 380                 


Val Gly His Asn Phe Gly Ser Pro His Asp Ser Gly Thr Glu Cys Thr 
385                 390                 395                 400 


Pro Gly Glu Ser Lys Asn Leu Gly Gln Lys Glu Asn Gly Asn Tyr Ile 
                405                 410                 415     


Met Tyr Ala Arg Ala Thr Ser Gly Asp Lys Leu Asn Asn Asn Lys Phe 
            420                 425                 430         


Ser Leu Cys Ser Ile Arg Asn Ile Ser Gln Val Leu Glu Lys Lys Arg 
        435                 440                 445             


Asn Asn Cys Phe Val Glu Ser Gly Gln Pro Ile Cys Gly Asn Gly Met 
    450                 455                 460                 


Val Glu Gln Gly Glu Glu Cys Asp Cys Gly Tyr Ser Asp Gln Cys Lys 
465                 470                 475                 480 


Asp Glu Cys Cys Phe Asp Ala Asn Gln Pro Glu Gly Arg Lys Cys Lys 
                485                 490                 495     


Leu Lys Pro Gly Lys Gln Cys Ser Pro Ser Gln Gly Pro Cys Cys Thr 
            500                 505                 510         


Ala Gln Cys Ala Phe Lys Ser Lys Ser Glu Lys Cys Arg Asp Asp Ser 
        515                 520                 525             


Asp Cys Ala Arg Glu Gly Ile Cys Asn Gly Phe Thr Ala Leu Cys Pro 
    530                 535                 540                 


Ala Ser Asp Pro Lys Pro Asn Phe Thr Asp Cys Asn Arg His Thr Gln 
545                 550                 555                 560 


Val Cys Ile Asn Gly Gln Cys Ala Gly Ser Ile Cys Glu Lys Tyr Gly 
                565                 570                 575     


Leu Glu Glu Cys Thr Cys Ala Ser Ser Asp Gly Lys Asp Asp Lys Glu 
            580                 585                 590         


Leu Cys His Val Cys Cys Met Lys Lys Met Asp Pro Ser Thr Cys Ala 
        595                 600                 605             


Ser Thr Gly Ser Val Gln Trp Ser Arg His Phe Ser Gly Arg Thr Ile 
    610                 615                 620                 


Thr Leu Gln Pro Gly Ser Pro Cys Asn Asp Phe Arg Gly Tyr Cys Asp 
625                 630                 635                 640 


Val Phe Met Arg Cys Arg Leu Val Asp Ala Asp Gly Pro Leu Ala Arg 
                645                 650                 655     


Leu Lys Lys Ala Ile Phe Ser Pro Glu Leu Tyr Glu Asn Ile Ala Glu 
            660                 665                 670         


Trp Ile Val Ala His Trp Trp Ala Val Leu Leu Met Gly Ile Ala Leu 
        675                 680                 685             


Ile Met Leu Met Ala Gly Phe Ile Lys Ile Cys Ser Val His Thr Pro 
    690                 695                 700                 


Ser Ser Asn Pro Lys Leu Pro Pro Pro Lys Pro Leu Pro Gly Thr Leu 
705                 710                 715                 720 


Lys Arg Arg Arg Pro Pro Gln Pro Ile Gln Gln Pro Gln Arg Gln Arg 
                725                 730                 735     


Pro Arg Glu Ser Tyr Gln Met Gly His Met Arg Arg 
            740                 745             


<210>  1234
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  1234

Met Arg Leu Trp Pro Trp Val Leu Val Trp Val Trp Leu Ala Ala Leu 
1               5                   10                  15      


Gly Ala Ile Glu Thr Ala Pro Arg Pro Lys Arg Ala Thr Ala Ser Ala 
            20                  25                  30          


Leu Gly Thr Glu Ser Pro Arg Phe Leu Asp Arg Pro Asp Phe Phe Asp 
        35                  40                  45              


Tyr Pro Asp Ser Asp Gln Ala Arg Leu Leu Ala Val Ala Gln Phe Ile 
    50                  55                  60                  


Gly Glu Lys Pro Ile Val Phe Ile Asn Ser Gly Ser Ser Pro Gly Leu 
65                  70                  75                  80  


Phe His His Ile Leu Val Gly Leu Leu Val Val Ala Phe Phe Phe Leu 
                85                  90                  95      


Leu Phe Gln Phe Cys Thr His Ile Asn Phe Gln Lys Gly Ala 
            100                 105                 110 


<210>  1235
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  1235

Met Gly Ala Gly Val Gly Val Ala Gly Cys Thr Arg Gly His Arg Asn 
1               5                   10                  15      


Trp Val Pro Ser Gln Leu Pro Pro Arg Glu Ile Lys Ala Gly Val Ser 
            20                  25                  30          


Leu Ala Val Val Thr Glu Phe Ala Trp Val Leu Ala Pro Arg Pro Lys 
        35                  40                  45              


Arg Ala Thr Ala Ser Ala Leu Gly Thr Glu Ser Pro Arg Phe Leu Asp 
    50                  55                  60                  


Arg Pro Asp Phe Phe Asp Tyr Pro Asp Ser Asp Gln Ala Arg Leu Leu 
65                  70                  75                  80  


Ala Val Ala Gln Phe Ile Gly Glu Lys Pro Ile Val Phe Ile Asn Ser 
                85                  90                  95      


Gly Ser Ser Pro Gly Leu Phe His His Ile Leu Val Gly Leu Leu Val 
            100                 105                 110         


Val Ala Phe Phe Phe Leu Leu Phe Gln Phe Cys Thr His Ile Asn Phe 
        115                 120                 125             


Gln Lys Gly Ala 
    130         


<210>  1236
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  1236

Met Lys Thr Ser Arg Arg Gly Arg Ala Leu Leu Ala Val Ala Leu Asn 
1               5                   10                  15      


Leu Leu Ala Leu Leu Phe Ala Thr Thr Ala Phe Leu Thr Thr His Trp 
            20                  25                  30          


Cys Gln Gly Thr Gln Arg Val Pro Lys Pro Gly Cys Gly Gln Gly Gly 
        35                  40                  45              


Arg Ala Asn Cys Pro Asn Ser Gly Ala Asn Ala Thr Ala Asn Gly Thr 
    50                  55                  60                  


Ala Ala Pro Ala Ala Ala Ala Ala Ala Ala Thr Ala Ser Gly Asn Gly 
65                  70                  75                  80  


Pro Pro Gly Gly Ala Leu Tyr Ser Trp Glu Thr Gly Asp Asp Arg Phe 
                85                  90                  95      


Leu Phe Arg Asn Phe His Thr Gly Ile Trp Tyr Ser Cys Glu Glu Glu 
            100                 105                 110         


Leu Ser Gly Leu Gly Glu Lys Cys Arg Ser Phe Ile Asp Leu Ala Pro 
        115                 120                 125             


Ala Ser Glu Lys Gly Val Leu Trp Leu Ser Val Val Ser Glu Val Leu 
    130                 135                 140                 


Tyr Ile Leu Leu Leu Val Val Gly Phe Ser Leu Met Cys Leu Glu Leu 
145                 150                 155                 160 


Phe His Ser Ser Asn Val Ile Asp Gly Leu Lys Leu Asn Ala Phe Ala 
                165                 170                 175     


Ala Val Phe Thr Val Leu Ser Gly Leu Leu Gly Met Val Ala His Met 
            180                 185                 190         


Met Tyr Thr Gln Val Phe Gln Val Thr Val Ser Leu Gly Pro Glu Asp 
        195                 200                 205             


Trp Arg Pro His Ser Trp Asp Tyr Gly Trp Ser Phe Cys Leu Ala Trp 
    210                 215                 220                 


Gly Ser Phe Thr Cys Cys Met Ala Ala Ser Val Thr Thr Leu Asn Ser 
225                 230                 235                 240 


Tyr Thr Lys Thr Val Ile Glu Phe Arg His Lys Arg Lys Val Phe Glu 
                245                 250                 255     


Gln Gly Tyr Arg Glu Glu Pro Thr Phe Ile Asp Pro Glu Ala Ile Lys 
            260                 265                 270         


Tyr Phe Arg Glu Arg Met Glu Lys Arg Asp Gly Ser Glu Glu Asp Phe 
        275                 280                 285             


His Leu Asp Cys Arg His Glu Arg Tyr Pro Ala Arg His Gln Pro His 
    290                 295                 300                 


Met Ala Asp Ser Trp Pro Arg Ser Ser Ala Gln Glu Ala Pro Glu Leu 
305                 310                 315                 320 


Asn Arg Gln Cys Trp Val Leu Gly His Trp Val 
                325                 330     


<210>  1237
<211>  315
<212>  PRT
<213>  Homo sapiens

<400>  1237

Met Tyr Gln Pro Ser Arg Gly Ala Ala Arg Arg Leu Gly Pro Cys Leu 
1               5                   10                  15      


Arg Ala Tyr Gln Ala Arg Pro Gln Asp Gln Leu Tyr Pro Gly Thr Leu 
            20                  25                  30          


Pro Phe Pro Pro Leu Trp Pro His Ser Thr Thr Thr Thr Ser Pro Ser 
        35                  40                  45              


Ser Pro Leu Phe Trp Ser Pro Leu Pro Pro Arg Leu Pro Thr Gln Arg 
    50                  55                  60                  


Leu Pro Gln Val Pro Pro Leu Pro Leu Pro Gln Ile Gln Ala Leu Ser 
65                  70                  75                  80  


Ser Ala Trp Val Val Leu Pro Pro Gly Lys Gly Glu Glu Gly Pro Gly 
                85                  90                  95      


Pro Glu Leu His Ser Gly Cys Leu Asp Gly Leu Arg Ser Leu Phe Glu 
            100                 105                 110         


Gly Pro Pro Cys Pro Tyr Pro Gly Ala Trp Ile Pro Phe Gln Val Pro 
        115                 120                 125             


Gly Thr Ala His Pro Ser Pro Ala Thr Pro Ser Gly Asp Pro Ser Met 
    130                 135                 140                 


Glu Glu His Leu Ser Val Met Tyr Glu Arg Leu Arg Gln Glu Leu Pro 
145                 150                 155                 160 


Lys Leu Phe Leu Gln Ser His Asp Tyr Ser Leu Tyr Ser Leu Asp Val 
                165                 170                 175     


Glu Phe Ile Asn Glu Ile Leu Asn Ile Arg Thr Lys Gly Arg Thr Trp 
            180                 185                 190         


Tyr Ile Leu Ser Leu Thr Leu Cys Arg Phe Leu Ala Trp Asn Tyr Phe 
        195                 200                 205             


Ala His Leu Arg Leu Glu Val Leu Gln Leu Thr Arg His Pro Glu Asn 
    210                 215                 220                 


Trp Thr Leu Gln Ala Arg Trp Arg Leu Val Gly Leu Pro Val His Leu 
225                 230                 235                 240 


Leu Phe Leu Arg Phe Tyr Lys Arg Asp Lys Asp Glu His Tyr Arg Thr 
                245                 250                 255     


Tyr Asp Ala Tyr Ser Thr Phe Tyr Leu Asn Ser Ser Gly Leu Ile Cys 
            260                 265                 270         


Arg His Arg Leu Asp Lys Leu Met Pro Ser His Ser Pro Pro Thr Pro 
        275                 280                 285             


Val Lys Lys Leu Leu Val Gly Ala Leu Val Ala Leu Gly Leu Ser Glu 
    290                 295                 300                 


Pro Glu Pro Asp Leu Asn Leu Cys Ser Lys Pro 
305                 310                 315 


<210>  1238
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  1238

Met Asp Trp Gly Thr Leu His Thr Phe Ile Gly Gly Val Asn Lys His 
1               5                   10                  15      


Ser Thr Ser Ile Gly Lys Val Trp Ile Thr Val Ile Phe Ile Phe Arg 
            20                  25                  30          


Val Met Ile Leu Val Val Ala Ala Gln Glu Val Trp Gly Asp Glu Gln 
        35                  40                  45              


Glu Asp Phe Val Cys Asn Thr Leu Gln Pro Gly Cys Lys Asn Val Cys 
    50                  55                  60                  


Tyr Asp His Phe Phe Pro Val Ser His Ile Arg Leu Trp Ala Leu Gln 
65                  70                  75                  80  


Leu Ile Phe Val Ser Thr Pro Ala Leu Leu Val Ala Met His Val Ala 
                85                  90                  95      


Tyr Tyr Arg His Glu Thr Thr Arg Lys Phe Arg Arg Gly Glu Lys Arg 
            100                 105                 110         


Asn Asp Phe Lys Asp Ile Glu Asp Ile Lys Lys Gln Lys Val Arg Ile 
        115                 120                 125             


Glu Gly Ser Leu Trp Trp Thr Tyr Thr Ser Ser Ile Phe Phe Arg Ile 
    130                 135                 140                 


Ile Phe Glu Ala Ala Phe Met Tyr Val Phe Tyr Phe Leu Tyr Asn Gly 
145                 150                 155                 160 


Tyr His Leu Pro Trp Val Leu Lys Cys Gly Ile Asp Pro Cys Pro Asn 
                165                 170                 175     


Leu Val Asp Cys Phe Ile Ser Arg Pro Thr Glu Lys Thr Val Phe Thr 
            180                 185                 190         


Ile Phe Met Ile Ser Ala Ser Val Ile Cys Met Leu Leu Asn Val Ala 
        195                 200                 205             


Glu Leu Cys Tyr Leu Leu Leu Lys Val Cys Phe Arg Arg Ser Lys Arg 
    210                 215                 220                 


Ala Gln Thr Gln Lys Asn His Pro Asn His Ala Leu Lys Glu Ser Lys 
225                 230                 235                 240 


Gln Asn Glu Met Asn Glu Leu Ile Ser Asp Ser Gly Gln Asn Ala Ile 
                245                 250                 255     


Thr Gly Phe Pro Ser 
            260     


<210>  1239
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  1239

Met Asp Trp Gly Thr Leu His Thr Phe Ile Gly Gly Val Asn Lys His 
1               5                   10                  15      


Ser Thr Ser Ile Gly Lys Val Trp Ile Thr Val Ile Phe Ile Phe Arg 
            20                  25                  30          


Val Met Ile Leu Val Val Ala Ala Gln Glu Val Trp Gly Asp Glu Gln 
        35                  40                  45              


Glu Asp Phe Val Cys Asn Thr Leu Gln Pro Gly Cys Lys Asn Val Cys 
    50                  55                  60                  


Tyr Asp His Phe Phe Pro Val Ser His Ile Arg Leu Trp Ala Leu Gln 
65                  70                  75                  80  


Leu Ile Phe Val Ser Thr Pro Ala Leu Leu Val Ala Met His Val Ala 
                85                  90                  95      


Tyr Tyr Arg His Glu Thr Thr Arg Lys Phe Arg Arg Gly Glu Lys Arg 
            100                 105                 110         


Asn Asp Phe Lys Asp Ile Glu Asp Ile Lys Lys Gln Lys Val Arg Ile 
        115                 120                 125             


Glu Gly Ser Leu Trp Trp Thr Tyr Thr Ser Ser Ile Phe Phe Arg Ile 
    130                 135                 140                 


Ile Phe Glu Ala Ala Phe Met Tyr Val Phe Tyr Phe Leu Tyr Asn Gly 
145                 150                 155                 160 


Tyr His Leu Pro Trp Val Leu Lys Cys Gly Ile Asp Pro Cys Pro Asn 
                165                 170                 175     


Leu Val Asp Cys Phe Ile Ser Arg Pro Thr Glu Lys Thr Val Phe Thr 
            180                 185                 190         


Ile Phe Met Ile Ser Ala Ser Val Ile Cys Met Leu Leu Asn Val Ala 
        195                 200                 205             


Glu Leu Cys Tyr Leu Leu Leu Lys Val Cys Phe Arg Arg Ser Lys Arg 
    210                 215                 220                 


Ala Gln Thr Gln Lys Asn His Pro Asn His Ala Leu Lys Glu Ser Lys 
225                 230                 235                 240 


Gln Asn Glu Met Asn Glu Leu Ile Ser Asp Ser Gly Gln Asn Ala Ile 
                245                 250                 255     


Thr Gly Phe Pro Ser 
            260     


<210>  1240
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  1240

Met Asp Trp Gly Thr Leu His Thr Phe Ile Gly Gly Val Asn Lys His 
1               5                   10                  15      


Ser Thr Ser Ile Gly Lys Val Trp Ile Thr Val Ile Phe Ile Phe Arg 
            20                  25                  30          


Val Met Ile Leu Val Val Ala Ala Gln Glu Val Trp Gly Asp Glu Gln 
        35                  40                  45              


Glu Asp Phe Val Cys Asn Thr Leu Gln Pro Gly Cys Lys Asn Val Cys 
    50                  55                  60                  


Tyr Asp His Phe Phe Pro Val Ser His Ile Arg Leu Trp Ala Leu Gln 
65                  70                  75                  80  


Leu Ile Phe Val Ser Thr Pro Ala Leu Leu Val Ala Met His Val Ala 
                85                  90                  95      


Tyr Tyr Arg His Glu Thr Thr Arg Lys Phe Arg Arg Gly Glu Lys Arg 
            100                 105                 110         


Asn Asp Phe Lys Asp Ile Glu Asp Ile Lys Lys Gln Lys Val Arg Ile 
        115                 120                 125             


Glu Gly Ser Leu Trp Trp Thr Tyr Thr Ser Ser Ile Phe Phe Arg Ile 
    130                 135                 140                 


Ile Phe Glu Ala Ala Phe Met Tyr Val Phe Tyr Phe Leu Tyr Asn Gly 
145                 150                 155                 160 


Tyr His Leu Pro Trp Val Leu Lys Cys Gly Ile Asp Pro Cys Pro Asn 
                165                 170                 175     


Leu Val Asp Cys Phe Ile Ser Arg Pro Thr Glu Lys Thr Val Phe Thr 
            180                 185                 190         


Ile Phe Met Ile Ser Ala Ser Val Ile Cys Met Leu Leu Asn Val Ala 
        195                 200                 205             


Glu Leu Cys Tyr Leu Leu Leu Lys Val Cys Phe Arg Arg Ser Lys Arg 
    210                 215                 220                 


Ala Gln Thr Gln Lys Asn His Pro Asn His Ala Leu Lys Glu Ser Lys 
225                 230                 235                 240 


Gln Asn Glu Met Asn Glu Leu Ile Ser Asp Ser Gly Gln Asn Ala Ile 
                245                 250                 255     


Thr Gly Phe Pro Ser 
            260     


<210>  1241
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  1241

Met Ala Ala Ala Ala Trp Leu Gln Val Leu Pro Val Ile Leu Leu Leu 
1               5                   10                  15      


Leu Gly Ala His Pro Ser Pro Leu Ser Phe Phe Ser Ala Gly Pro Ala 
            20                  25                  30          


Thr Val Ala Ala Ala Asp Arg Ser Lys Trp His Ile Pro Ile Pro Ser 
        35                  40                  45              


Gly Lys Asn Tyr Phe Ser Phe Gly Lys Ile Leu Phe Arg Asn Thr Thr 
    50                  55                  60                  


Ile Phe Leu Lys Phe Asp Gly Glu Pro Cys Asp Leu Ser Leu Asn Ile 
65                  70                  75                  80  


Thr Trp Tyr Leu Lys Ser Ala Asp Cys Tyr Asn Glu Ile Tyr Asn Phe 
                85                  90                  95      


Lys Ala Glu Glu Val Glu Leu Tyr Leu Glu Lys Leu Lys Glu Lys Arg 
            100                 105                 110         


Gly Leu Ser Gly Lys Tyr Gln Thr Ser Ser Lys Leu Phe Gln Asn Cys 
        115                 120                 125             


Ser Glu Leu Phe Lys Thr Gln Thr Phe Ser Gly Asp Phe Met His Arg 
    130                 135                 140                 


Leu Pro Leu Leu Gly Glu Lys Gln Glu Ala Lys Glu Asn Gly Thr Asn 
145                 150                 155                 160 


Leu Thr Phe Ile Gly Asp Lys Thr Ile Gln Met Pro Phe Leu Lys Lys 
                165                 170                 175     


His Phe Leu Asp Cys 
            180     


<210>  1242
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  1242

Met Ser Ser Ser Val Lys Thr Pro Ala Leu Glu Glu Leu Val Pro Gly 
1               5                   10                  15      


Ser Glu Glu Lys Pro Lys Gly Arg Ser Pro Leu Ser Trp Gly Ser Leu 
            20                  25                  30          


Phe Gly His Arg Ser Glu Lys Ile Val Phe Ala Lys Ser Asp Gly Gly 
        35                  40                  45              


Thr Asp Glu Asn Val Leu Thr Val Thr Ile Thr Glu Thr Thr Val Ile 
    50                  55                  60                  


Glu Ser Asp Leu Gly Val Trp Ser Ser Arg Ala Leu Leu Tyr Leu Thr 
65                  70                  75                  80  


Leu Trp Phe Phe Phe Ser Phe Cys Thr Leu Phe Leu Asn Lys Tyr Ile 
                85                  90                  95      


Leu Ser Leu Leu Gly Gly Glu Pro Ser Met Leu Gly Ala Val Gln Met 
            100                 105                 110         


Leu Ser Thr Thr Val Ile Gly Cys Val Lys Thr Leu Val Pro Cys Cys 
        115                 120                 125             


Leu Tyr Gln His Lys Ala Arg Leu Ser Tyr Pro Pro Asn Phe Leu Met 
    130                 135                 140                 


Thr Met Leu Phe Val Gly Leu Met Arg Phe Ala Thr Val Val Leu Gly 
145                 150                 155                 160 


Leu Val Ser Leu Lys Asn Val Ala Val Ser Phe Ala Glu Thr Val Lys 
                165                 170                 175     


Ser Ser Ala Pro Ile Phe Thr Val Ile Met Ser Arg Met Ile Leu Gly 
            180                 185                 190         


Glu Tyr Thr Gly Leu Leu Val Asn Leu Ser Leu Ile Pro Val Met Gly 
        195                 200                 205             


Gly Leu Ala Leu Cys Thr Ala Thr Glu Ile Ser Phe Asn Val Leu Gly 
    210                 215                 220                 


Phe Ser Ala Ala Leu Ser Thr Asn Ile Met Asp Cys Leu Gln Asn Val 
225                 230                 235                 240 


Phe Ser Lys Lys Leu Leu Ser Gly Asp Lys Tyr Arg Phe Ser Ala Pro 
                245                 250                 255     


Glu Leu Gln Phe Tyr Thr Ser Ala Ala Ala Val Ala Met Leu Val Pro 
            260                 265                 270         


Ala Arg Val Phe Phe Thr Asp Val Pro Val Ile Gly Arg Ser Gly Lys 
        275                 280                 285             


Ser Phe Ser Tyr Asn Gln Asp Val Val Leu Leu Leu Leu Thr Asp Gly 
    290                 295                 300                 


Val Leu Phe His Leu Gln Ser Val Thr Ala Tyr Ala Leu Met Gly Lys 
305                 310                 315                 320 


Ile Ser Pro Val Thr Phe Ser Val Ala Ser Thr Val Lys His Ala Leu 
                325                 330                 335     


Ser Ile Trp Leu Ser Val Ile Val Phe Gly Asn Lys Ile Thr Ser Leu 
            340                 345                 350         


Ser Ala Val Gly Thr Ala Leu Val Thr Val Gly Val Leu Leu Tyr Asn 
        355                 360                 365             


Lys Ala Arg Gln His Gln Gln Glu Ala Leu Gln Ser Leu Ala Ala Ala 
    370                 375                 380                 


Thr Gly Arg Ala Pro Asp Asp Thr Val Glu Pro Leu Leu Pro Gln Asp 
385                 390                 395                 400 


Pro Arg Gln His Pro 
                405 


<210>  1243
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  1243

Met Leu Thr Asn Gly Lys Glu Gln Val Ile Lys Ser Cys Val Ser Leu 
1               5                   10                  15      


Pro Glu Leu Asn Ala Gln Val Phe Cys His Ser Ser Asn Asn Val Thr 
            20                  25                  30          


Lys Thr Glu Cys Cys Phe Thr Asp Phe Cys Asn Asn Ile Thr Leu His 
        35                  40                  45              


Leu Pro Thr Ala Ser Pro Asn Ala Pro Lys Leu Gly Pro Met Glu Leu 
    50                  55                  60                  


Ala Ile Ile Ile Thr Val Pro Val Cys Leu Leu Ser Ile Ala Ala Met 
65                  70                  75                  80  


Leu Thr Val Trp Ala Cys Gln Gly Arg Gln Cys Ser Tyr Arg Lys Lys 
                85                  90                  95      


Lys Arg Pro Asn Val Glu Glu Pro Leu Ser Glu Cys Asn Leu Val Asn 
            100                 105                 110         


Ala Gly Lys Thr Leu Lys Asp Leu Ile Tyr Asp Val Thr Ala Ser Gly 
        115                 120                 125             


Ser Gly Ser Gly Leu Pro Leu Leu Val Gln Arg Thr Ile Ala Arg Thr 
    130                 135                 140                 


Ile Val Leu Gln Glu Ile Val Gly Lys Gly Arg Phe Gly Glu Val Trp 
145                 150                 155                 160 


His Gly Arg Trp Cys Gly Glu Asp Val Ala Val Lys Ile Phe Ser Ser 
                165                 170                 175     


Arg Asp Glu Arg Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Thr Val 
            180                 185                 190         


Met Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys 
        195                 200                 205             


Asp Asn Gly Thr Trp Thr Gln Leu Trp Leu Val Ser Glu Tyr His Glu 
    210                 215                 220                 


Gln Gly Ser Leu Tyr Asp Tyr Leu Asn Arg Asn Ile Val Thr Val Ala 
225                 230                 235                 240 


Gly Met Ile Lys Leu Ala Leu Ser Ile Ala Ser Gly Leu Ala His Leu 
                245                 250                 255     


His Met Glu Ile Val Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg 
            260                 265                 270         


Asp Ile Lys Ser Lys Asn Ile Leu Val Lys Lys Cys Glu Thr Cys Ala 
        275                 280                 285             


Ile Ala Asp Leu Gly Leu Ala Val Lys His Asp Ser Ile Leu Asn Thr 
    290                 295                 300                 


Ile Asp Ile Pro Gln Asn Pro Lys Val Gly Thr Lys Arg Tyr Met Ala 
305                 310                 315                 320 


Pro Glu Met Leu Asp Asp Thr Met Asn Val Asn Ile Phe Glu Ser Phe 
                325                 330                 335     


Lys Arg Ala Asp Ile Tyr Ser Val Gly Leu Val Tyr Trp Glu Ile Ala 
            340                 345                 350         


Arg Arg Cys Ser Val Gly Gly Ile Val Glu Glu Tyr Gln Leu Pro Tyr 
        355                 360                 365             


Tyr Asp Met Val Pro Ser Asp Pro Ser Ile Glu Glu Met Arg Lys Val 
    370                 375                 380                 


Val Cys Asp Gln Lys Phe Arg Pro Ser Ile Pro Asn Gln Trp Gln Ser 
385                 390                 395                 400 


Cys Glu Ala Leu Arg Val Met Gly Arg Ile Met Arg Glu Cys Trp Tyr 
                405                 410                 415     


Ala Asn Gly Ala Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Ile 
            420                 425                 430         


Ser Gln Leu Cys Val Lys Glu Asp Cys Lys Ala 
        435                 440             


<210>  1244
<211>  413
<212>  PRT
<213>  Homo sapiens

<400>  1244

Met Thr Arg Ala Leu Cys Ser Ala Leu Arg Gln Ala Leu Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Ala Glu Leu Ser Pro Gly Leu Lys Cys Val Cys Leu Leu 
            20                  25                  30          


Cys Asp Ser Ser Asn Phe Thr Cys Gln Thr Glu Gly Ala Cys Trp Ala 
        35                  40                  45              


Ser Val Met Leu Thr Asn Gly Lys Glu Gln Val Ile Lys Ser Cys Val 
    50                  55                  60                  


Ser Leu Pro Glu Leu Asn Ala Gln Val Phe Cys His Ser Ser Asn Asn 
65                  70                  75                  80  


Val Thr Lys Thr Glu Cys Cys Phe Thr Asp Phe Cys Asn Asn Ile Thr 
                85                  90                  95      


Leu His Leu Pro Thr Gly Leu Pro Leu Leu Val Gln Arg Thr Ile Ala 
            100                 105                 110         


Arg Thr Ile Val Leu Gln Glu Ile Val Gly Lys Gly Arg Phe Gly Glu 
        115                 120                 125             


Val Trp His Gly Arg Trp Cys Gly Glu Asp Val Ala Val Lys Ile Phe 
    130                 135                 140                 


Ser Ser Arg Asp Glu Arg Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln 
145                 150                 155                 160 


Thr Val Met Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp 
                165                 170                 175     


Asn Lys Asp Asn Gly Thr Trp Thr Gln Leu Trp Leu Val Ser Glu Tyr 
            180                 185                 190         


His Glu Gln Gly Ser Leu Tyr Asp Tyr Leu Asn Arg Asn Ile Val Thr 
        195                 200                 205             


Val Ala Gly Met Ile Lys Leu Ala Leu Ser Ile Ala Ser Gly Leu Ala 
    210                 215                 220                 


His Leu His Met Glu Ile Val Gly Thr Gln Gly Lys Pro Ala Ile Ala 
225                 230                 235                 240 


His Arg Asp Ile Lys Ser Lys Asn Ile Leu Val Lys Lys Cys Glu Thr 
                245                 250                 255     


Cys Ala Ile Ala Asp Leu Gly Leu Ala Val Lys His Asp Ser Ile Leu 
            260                 265                 270         


Asn Thr Ile Asp Ile Pro Gln Asn Pro Lys Val Gly Thr Lys Arg Tyr 
        275                 280                 285             


Met Ala Pro Glu Met Leu Asp Asp Thr Met Asn Val Asn Ile Phe Glu 
    290                 295                 300                 


Ser Phe Lys Arg Ala Asp Ile Tyr Ser Val Gly Leu Val Tyr Trp Glu 
305                 310                 315                 320 


Ile Ala Arg Arg Cys Ser Val Gly Gly Ile Val Glu Glu Tyr Gln Leu 
                325                 330                 335     


Pro Tyr Tyr Asp Met Val Pro Ser Asp Pro Ser Ile Glu Glu Met Arg 
            340                 345                 350         


Lys Val Val Cys Asp Gln Lys Phe Arg Pro Ser Ile Pro Asn Gln Trp 
        355                 360                 365             


Gln Ser Cys Glu Ala Leu Arg Val Met Gly Arg Ile Met Arg Glu Cys 
    370                 375                 380                 


Trp Tyr Ala Asn Gly Ala Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys 
385                 390                 395                 400 


Thr Ile Ser Gln Leu Cys Val Lys Glu Asp Cys Lys Ala 
                405                 410             


<210>  1245
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  1245

Met Thr Arg Ala Leu Cys Ser Ala Leu Arg Gln Ala Leu Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Ala Glu Leu Ser Pro Gly Leu Lys Cys Val Cys Leu Leu 
            20                  25                  30          


Cys Asp Ser Ser Asn Phe Thr Cys Gln Thr Glu Gly Ala Cys Trp Ala 
        35                  40                  45              


Ser Val Met Leu Thr Asn Gly Lys Glu Gln Val Ile Lys Ser Cys Val 
    50                  55                  60                  


Ser Leu Pro Glu Leu Asn Ala Gln Val Phe Cys His Ser Ser Asn Asn 
65                  70                  75                  80  


Val Thr Lys Thr Glu Cys Cys Phe Thr Asp Phe Cys Asn Asn Ile Thr 
                85                  90                  95      


Leu His Leu Pro Thr Asp Asn Gly Thr Trp Thr Gln Leu Trp Leu Val 
            100                 105                 110         


Ser Glu Tyr His Glu Gln Gly Ser Leu Tyr Asp Tyr Leu Asn Arg Asn 
        115                 120                 125             


Ile Val Thr Val Ala Gly Met Ile Lys Leu Ala Leu Ser Ile Ala Ser 
    130                 135                 140                 


Gly Leu Ala His Leu His Met Glu Ile Val Gly Thr Gln Gly Lys Pro 
145                 150                 155                 160 


Ala Ile Ala His Arg Asp Ile Lys Ser Lys Asn Ile Leu Val Lys Lys 
                165                 170                 175     


Cys Glu Thr Cys Ala Ile Ala Asp Leu Gly Leu Ala Val Lys His Asp 
            180                 185                 190         


Ser Ile Leu Asn Thr Ile Asp Ile Pro Gln Asn Pro Lys Val Gly Thr 
        195                 200                 205             


Lys Arg Tyr Met Ala Pro Glu Met Leu Asp Asp Thr Met Asn Val Asn 
    210                 215                 220                 


Ile Phe Glu Ser Phe Lys Arg Ala Asp Ile Tyr Ser Val Gly Leu Val 
225                 230                 235                 240 


Tyr Trp Glu Ile Ala Arg Arg Cys Ser Val Gly Gly Ile Val Glu Glu 
                245                 250                 255     


Tyr Gln Leu Pro Tyr Tyr Asp Met Val Pro Ser Asp Pro Ser Ile Glu 
            260                 265                 270         


Glu Met Arg Lys Val Val Cys Asp Gln Lys Phe Arg Pro Ser Ile Pro 
        275                 280                 285             


Asn Gln Trp Gln Ser Cys Glu Ala Leu Arg Val Met Gly Arg Ile Met 
    290                 295                 300                 


Arg Glu Cys Trp Tyr Ala Asn Gly Ala Ala Arg Leu Thr Ala Leu Arg 
305                 310                 315                 320 


Ile Lys Lys Thr Ile Ser Gln Leu Cys Val Lys Glu Asp Cys Lys Ala 
                325                 330                 335     


<210>  1246
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  1246

Met Val Asp Gly Val Met Ile Leu Pro Val Leu Ile Met Ile Ala Leu 
1               5                   10                  15      


Pro Ser Pro Ser Met Glu Asp Glu Lys Pro Lys Val Asn Pro Lys Leu 
            20                  25                  30          


Tyr Met Cys Val Cys Glu Gly Leu Ser Cys Gly Asn Glu Asp His Cys 
        35                  40                  45              


Glu Gly Gln Gln Cys Phe Ser Ser Leu Ser Ile Asn Asp Gly Phe His 
    50                  55                  60                  


Val Tyr Gln Lys Gly Cys Phe Gln Val Tyr Glu Gln Gly Lys Met Thr 
65                  70                  75                  80  


Cys Lys Thr Pro Pro Ser Pro Gly Gln Ala Val Glu Cys Cys Gln Gly 
                85                  90                  95      


Asp Trp Cys Asn Arg Asn Ile Thr Ala Gln Leu Pro Thr Lys Gly Lys 
            100                 105                 110         


Ser Phe Pro Gly Thr Gln Asn Phe His Leu Glu Val Gly Leu Ile Ile 
        115                 120                 125             


Leu Ser Val Val Phe Ala Val Cys Leu Leu Ala Cys Leu Leu Gly Val 
    130                 135                 140                 


Ala Leu Arg Lys Phe Lys Arg Arg Asn Gln Glu Arg Leu Asn Pro Arg 
145                 150                 155                 160 


Asp Val Glu Tyr Gly Thr Ile Glu Gly Leu Ile Thr Thr Asn Val Gly 
                165                 170                 175     


Asp Ser Thr Leu Ala Asp Leu Leu Asp His Ser Cys Thr Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Leu Pro Phe Leu Val Gln Arg Thr Val Ala Arg Gln Ile 
        195                 200                 205             


Thr Leu Leu Glu Cys Val Gly Lys Gly Arg Tyr Gly Glu Val Trp Arg 
    210                 215                 220                 


Gly Ser Trp Gln Gly Glu Asn Val Ala Val Lys Ile Phe Ser Ser Arg 
225                 230                 235                 240 


Asp Glu Lys Ser Trp Phe Arg Glu Thr Glu Leu Tyr Asn Thr Val Met 
                245                 250                 255     


Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ser Asp Met Thr Ser 
            260                 265                 270         


Arg His Ser Ser Thr Gln Leu Trp Leu Ile Thr His Tyr His Glu Met 
        275                 280                 285             


Gly Ser Leu Tyr Asp Tyr Leu Gln Leu Thr Thr Leu Asp Thr Val Ser 
    290                 295                 300                 


Cys Leu Arg Ile Val Leu Ser Ile Ala Ser Gly Leu Ala His Leu His 
305                 310                 315                 320 


Ile Glu Ile Phe Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp 
                325                 330                 335     


Leu Lys Ser Lys Asn Ile Leu Val Lys Lys Asn Gly Gln Cys Cys Ile 
            340                 345                 350         


Ala Asp Leu Gly Leu Ala Val Met His Ser Gln Ser Thr Asn Gln Leu 
        355                 360                 365             


Asp Val Gly Asn Asn Pro Arg Val Gly Thr Lys Arg Tyr Met Ala Pro 
    370                 375                 380                 


Glu Val Leu Asp Glu Thr Ile Gln Val Asp Cys Phe Asp Ser Tyr Lys 
385                 390                 395                 400 


Arg Val Asp Ile Trp Ala Phe Gly Leu Val Leu Trp Glu Val Ala Arg 
                405                 410                 415     


Arg Met Val Ser Asn Gly Ile Val Glu Asp Tyr Lys Pro Pro Phe Tyr 
            420                 425                 430         


Asp Val Val Pro Asn Asp Pro Ser Phe Glu Asp Met Arg Lys Val Val 
        435                 440                 445             


Cys Val Asp Gln Gln Arg Pro Asn Ile Pro Asn Arg Trp Phe Ser Asp 
    450                 455                 460                 


Pro Thr Leu Thr Ser Leu Ala Lys Leu Met Lys Glu Cys Trp Tyr Gln 
465                 470                 475                 480 


Asn Pro Ser Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Thr 
                485                 490                 495     


Lys Ile Asp Asn Ser Leu Asp Lys Leu Lys Thr Asp Cys 
            500                 505                 


<210>  1247
<211>  1080
<212>  PRT
<213>  Homo sapiens

<400>  1247

Met Pro Ala Lys Gly Arg Tyr Phe Leu Asn Glu Gly Glu Glu Gly Pro 
1               5                   10                  15      


Asp Gln Asp Ala Leu Tyr Glu Lys Tyr Gln Leu Thr Ser Gln His Gly 
            20                  25                  30          


Pro Leu Leu Leu Thr Leu Leu Leu Val Ala Ala Thr Ala Cys Val Ala 
        35                  40                  45              


Leu Ile Ile Ile Ala Phe Ser Gln Gly Asp Pro Ser Arg His Gln Ala 
    50                  55                  60                  


Ile Leu Gly Met Ala Phe Leu Val Leu Ala Val Phe Ala Ala Leu Ser 
65                  70                  75                  80  


Val Leu Met Tyr Val Glu Cys Leu Leu Arg Arg Trp Leu Arg Ala Leu 
                85                  90                  95      


Ala Leu Leu Thr Trp Ala Cys Leu Val Ala Leu Gly Tyr Val Leu Val 
            100                 105                 110         


Phe Asp Ala Trp Thr Lys Ala Ala Cys Ala Trp Glu Gln Val Pro Phe 
        115                 120                 125             


Phe Leu Phe Ile Val Phe Val Val Tyr Thr Leu Leu Pro Phe Ser Met 
    130                 135                 140                 


Arg Gly Ala Val Ala Val Gly Ala Val Ser Thr Ala Ser His Leu Leu 
145                 150                 155                 160 


Val Leu Gly Ser Leu Met Gly Gly Phe Thr Thr Pro Ser Val Arg Val 
                165                 170                 175     


Gly Leu Gln Leu Leu Ala Asn Ala Val Ile Phe Leu Cys Gly Asn Leu 
            180                 185                 190         


Thr Gly Ala Phe His Lys His Gln Met Gln Asp Ala Ser Arg Asp Leu 
        195                 200                 205             


Phe Thr Tyr Thr Val Lys Cys Ile Gln Ile Arg Arg Lys Leu Arg Ile 
    210                 215                 220                 


Glu Lys Arg Gln Gln Glu Asn Leu Leu Leu Ser Val Leu Pro Ala His 
225                 230                 235                 240 


Ile Ser Met Gly Met Lys Leu Ala Ile Ile Glu Arg Leu Lys Glu His 
                245                 250                 255     


Gly Asp Arg Arg Cys Met Pro Asp Asn Asn Phe His Ser Leu Tyr Val 
            260                 265                 270         


Lys Arg His Gln Asn Val Ser Ile Leu Tyr Ala Asp Ile Val Gly Phe 
        275                 280                 285             


Thr Gln Leu Ala Ser Asp Cys Ser Pro Lys Glu Leu Val Val Val Leu 
    290                 295                 300                 


Asn Glu Leu Phe Gly Lys Phe Asp Gln Ile Ala Lys Ala Asn Glu Cys 
305                 310                 315                 320 


Met Arg Ile Lys Ile Leu Gly Asp Cys Tyr Tyr Cys Val Ser Gly Leu 
                325                 330                 335     


Pro Val Ser Leu Pro Thr His Ala Arg Asn Cys Val Lys Met Gly Leu 
            340                 345                 350         


Asp Met Cys Gln Ala Ile Lys Gln Val Arg Glu Ala Thr Gly Val Asp 
        355                 360                 365             


Ile Asn Met Arg Val Gly Ile His Ser Gly Asn Val Leu Cys Gly Val 
    370                 375                 380                 


Ile Gly Leu Arg Lys Trp Gln Tyr Asp Val Trp Ser His Asp Val Ser 
385                 390                 395                 400 


Leu Ala Asn Arg Met Glu Ala Ala Gly Val Pro Gly Arg Val His Ile 
                405                 410                 415     


Thr Glu Ala Thr Leu Lys His Leu Asp Lys Ala Tyr Glu Val Glu Asp 
            420                 425                 430         


Gly His Gly Gln Gln Arg Asp Pro Tyr Leu Lys Glu Met Asn Ile Arg 
        435                 440                 445             


Thr Tyr Leu Val Ile Asp Pro Arg Ser Gln Gln Pro Pro Pro Pro Ser 
    450                 455                 460                 


Gln His Leu Pro Arg Pro Lys Gly Asp Ala Ala Leu Lys Met Arg Ala 
465                 470                 475                 480 


Ser Val Arg Met Thr Arg Tyr Leu Glu Ser Trp Gly Ala Ala Arg Pro 
                485                 490                 495     


Phe Ala His Leu Asn His Arg Glu Ser Val Ser Ser Gly Glu Thr His 
            500                 505                 510         


Val Pro Asn Gly Arg Arg Pro Lys Ser Val Pro Gln Arg His Arg Arg 
        515                 520                 525             


Thr Pro Asp Arg Ser Met Ser Pro Lys Gly Arg Ser Glu Asp Asp Ser 
    530                 535                 540                 


Tyr Asp Asp Glu Met Leu Ser Ala Ile Glu Gly Leu Ser Ser Thr Arg 
545                 550                 555                 560 


Pro Cys Cys Ser Lys Ser Asp Asp Phe Tyr Thr Phe Gly Ser Ile Phe 
                565                 570                 575     


Leu Glu Lys Gly Phe Glu Arg Glu Tyr Arg Leu Ala Pro Ile Pro Arg 
            580                 585                 590         


Ala Arg His Asp Phe Ala Cys Ala Ser Leu Ile Phe Val Cys Ile Leu 
        595                 600                 605             


Leu Val His Val Leu Leu Met Pro Arg Thr Ala Ala Leu Gly Val Ser 
    610                 615                 620                 


Phe Gly Leu Val Ala Cys Val Leu Gly Leu Val Leu Gly Leu Cys Phe 
625                 630                 635                 640 


Ala Thr Lys Phe Ser Arg Cys Cys Pro Ala Arg Gly Thr Leu Cys Thr 
                645                 650                 655     


Ile Ser Glu Arg Val Glu Thr Gln Pro Leu Leu Arg Leu Thr Leu Ala 
            660                 665                 670         


Val Leu Thr Ile Gly Ser Leu Leu Thr Val Ala Ile Ile Asn Leu Pro 
        675                 680                 685             


Leu Met Pro Phe Gln Val Pro Glu Leu Pro Val Gly Asn Glu Thr Gly 
    690                 695                 700                 


Leu Leu Ala Ala Ser Ser Lys Thr Arg Ala Leu Cys Glu Pro Leu Pro 
705                 710                 715                 720 


Tyr Tyr Thr Cys Ser Cys Val Leu Gly Phe Ile Ala Cys Ser Val Phe 
                725                 730                 735     


Leu Arg Met Ser Leu Glu Pro Lys Val Val Leu Leu Thr Val Ala Leu 
            740                 745                 750         


Val Ala Tyr Leu Val Leu Phe Asn Leu Ser Pro Cys Trp Gln Trp Asp 
        755                 760                 765             


Cys Cys Gly Gln Gly Leu Gly Asn Leu Thr Lys Pro Asn Gly Thr Thr 
    770                 775                 780                 


Ser Gly Thr Pro Ser Cys Ser Trp Lys Asp Leu Lys Thr Met Thr Asn 
785                 790                 795                 800 


Phe Tyr Leu Val Leu Phe Tyr Ile Thr Leu Leu Thr Leu Ser Arg Gln 
                805                 810                 815     


Ile Asp Tyr Tyr Cys Arg Leu Asp Cys Leu Trp Lys Lys Lys Phe Lys 
            820                 825                 830         


Lys Glu His Glu Glu Phe Glu Thr Met Glu Asn Val Asn Arg Leu Leu 
        835                 840                 845             


Leu Glu Asn Val Leu Pro Ala His Val Ala Ala His Phe Ile Gly Asp 
    850                 855                 860                 


Lys Leu Asn Glu Asp Trp Tyr His Gln Ser Tyr Asp Cys Val Cys Val 
865                 870                 875                 880 


Met Phe Ala Ser Val Pro Asp Phe Lys Val Phe Tyr Thr Glu Cys Asp 
                885                 890                 895     


Val Asn Lys Glu Gly Leu Glu Cys Leu Arg Leu Leu Asn Glu Ile Ile 
            900                 905                 910         


Ala Asp Phe Asp Glu Leu Leu Leu Lys Pro Lys Phe Ser Gly Val Glu 
        915                 920                 925             


Lys Ile Lys Thr Ile Gly Ser Thr Tyr Met Ala Ala Ala Gly Leu Ser 
    930                 935                 940                 


Val Ala Ser Gly His Glu Asn Gln Glu Leu Glu Arg Gln His Ala His 
945                 950                 955                 960 


Ile Gly Val Met Val Glu Phe Ser Ile Ala Leu Met Ser Lys Leu Asp 
                965                 970                 975     


Gly Ile Asn Arg His Ser Phe Asn Ser Phe Arg Leu Arg Val Gly Ile 
            980                 985                 990         


Asn His Gly Pro Val Ile Ala Gly  Val Ile Gly Ala Arg  Lys Pro Gln 
        995                 1000                 1005             


Tyr Asp  Ile Trp Gly Asn Thr  Val Asn Val Ala Ser  Arg Met Glu 
    1010                 1015                 1020             


Ser Thr  Gly Glu Leu Gly Lys  Ile Gln Val Thr Glu  Glu Thr Cys 
    1025                 1030                 1035             


Thr Ile  Leu Gln Gly Leu Gly  Tyr Ser Cys Glu Cys  Arg Gly Leu 
    1040                 1045                 1050             


Ile Asn  Val Lys Gly Lys Gly  Glu Leu Arg Thr Tyr  Phe Val Cys 
    1055                 1060                 1065             


Thr Asp  Thr Ala Lys Phe Gln  Gly Leu Gly Leu Asn  
    1070                 1075                 1080 


<210>  1248
<211>  1251
<212>  PRT
<213>  Homo sapiens

<400>  1248

Met Glu Leu Ser Asp Val Arg Cys Leu Thr Gly Ser Glu Glu Leu Tyr 
1               5                   10                  15      


Thr Ile His Pro Thr Pro Pro Ala Gly Asp Gly Arg Ser Ala Ser Arg 
            20                  25                  30          


Pro Gln Arg Leu Leu Trp Gln Thr Ala Val Arg His Ile Thr Glu Gln 
        35                  40                  45              


Arg Phe Ile His Gly His Arg Gly Gly Ser Gly Ser Gly Ser Gly Gly 
    50                  55                  60                  


Ser Gly Lys Ala Ser Asp Pro Ala Gly Gly Gly Pro Asn His His Ala 
65                  70                  75                  80  


Pro Gln Leu Ser Gly Asp Ser Ala Leu Pro Leu Tyr Ser Leu Gly Pro 
                85                  90                  95      


Gly Glu Arg Ala His Ser Thr Cys Gly Thr Lys Val Phe Pro Glu Arg 
            100                 105                 110         


Ser Gly Ser Gly Ser Ala Ser Gly Ser Gly Gly Gly Gly Asp Leu Gly 
        115                 120                 125             


Phe Leu His Leu Asp Cys Ala Pro Ser Asn Ser Asp Phe Phe Leu Asn 
    130                 135                 140                 


Gly Gly Tyr Ser Tyr Arg Gly Val Ile Phe Pro Thr Leu Arg Asn Ser 
145                 150                 155                 160 


Phe Lys Ser Arg Asp Leu Glu Arg Leu Tyr Gln Arg Tyr Phe Leu Gly 
                165                 170                 175     


Gln Arg Arg Lys Ser Glu Val Val Met Asn Val Leu Asp Val Leu Thr 
            180                 185                 190         


Lys Leu Thr Leu Leu Val Leu His Leu Ser Leu Ala Ser Ala Pro Met 
        195                 200                 205             


Asp Pro Leu Lys Gly Ile Leu Leu Gly Phe Phe Thr Gly Ile Glu Val 
    210                 215                 220                 


Val Ile Cys Ala Leu Val Val Val Arg Lys Asp Thr Thr Ser His Thr 
225                 230                 235                 240 


Tyr Leu Gln Tyr Ser Gly Val Val Thr Trp Val Ala Met Thr Thr Gln 
                245                 250                 255     


Ile Leu Ala Ala Gly Leu Gly Tyr Gly Leu Leu Gly Asp Gly Ile Gly 
            260                 265                 270         


Tyr Val Leu Phe Thr Leu Phe Ala Thr Tyr Ser Met Leu Pro Leu Pro 
        275                 280                 285             


Leu Thr Trp Ala Ile Leu Ala Gly Leu Gly Thr Ser Leu Leu Gln Val 
    290                 295                 300                 


Ile Leu Gln Val Val Ile Pro Arg Leu Ala Val Ile Ser Ile Asn Gln 
305                 310                 315                 320 


Val Val Ala Gln Ala Val Leu Phe Met Cys Met Asn Thr Ala Gly Ile 
                325                 330                 335     


Phe Ile Ser Tyr Leu Ser Asp Arg Ala Gln Arg Gln Ala Phe Leu Glu 
            340                 345                 350         


Thr Arg Arg Cys Val Glu Ala Arg Leu Arg Leu Glu Thr Glu Asn Gln 
        355                 360                 365             


Arg Gln Glu Arg Leu Val Leu Ser Val Leu Pro Arg Phe Val Val Leu 
    370                 375                 380                 


Glu Met Ile Asn Asp Met Thr Asn Val Glu Asp Glu His Leu Gln His 
385                 390                 395                 400 


Gln Phe His Arg Ile Tyr Ile His Arg Tyr Glu Asn Val Ser Ile Leu 
                405                 410                 415     


Phe Ala Asp Val Lys Gly Phe Thr Asn Leu Ser Thr Thr Leu Ser Ala 
            420                 425                 430         


Gln Glu Leu Val Arg Met Leu Asn Glu Leu Phe Ala Arg Phe Asp Arg 
        435                 440                 445             


Leu Ala His Glu His His Cys Leu Arg Ile Lys Ile Leu Gly Asp Cys 
    450                 455                 460                 


Tyr Tyr Cys Val Ser Gly Leu Pro Glu Pro Arg Gln Asp His Ala His 
465                 470                 475                 480 


Cys Cys Val Glu Met Gly Leu Ser Met Ile Lys Thr Ile Arg Tyr Val 
                485                 490                 495     


Arg Ser Arg Thr Lys His Asp Val Asp Met Arg Ile Gly Ile His Ser 
            500                 505                 510         


Gly Ser Val Leu Cys Gly Val Leu Gly Leu Arg Lys Trp Gln Phe Asp 
        515                 520                 525             


Val Trp Ser Trp Asp Val Asp Ile Ala Asn Lys Leu Glu Ser Gly Gly 
    530                 535                 540                 


Ile Pro Gly Arg Ile His Ile Ser Lys Ala Thr Leu Asp Cys Leu Asn 
545                 550                 555                 560 


Gly Asp Tyr Asn Val Glu Glu Gly His Gly Lys Glu Arg Asn Glu Phe 
                565                 570                 575     


Leu Arg Lys His Asn Ile Glu Thr Tyr Leu Ile Lys Gln Pro Glu Asp 
            580                 585                 590         


Ser Leu Leu Ser Leu Pro Glu Asp Ile Val Lys Glu Ser Val Ser Ser 
        595                 600                 605             


Ser Asp Arg Arg Asn Ser Gly Ala Thr Phe Thr Glu Gly Ser Trp Ser 
    610                 615                 620                 


Pro Glu Leu Pro Phe Asp Asn Ile Val Gly Lys Gln Asn Thr Leu Ala 
625                 630                 635                 640 


Ala Leu Thr Arg Asn Ser Ile Asn Leu Leu Pro Asn His Leu Ala Gln 
                645                 650                 655     


Ala Leu His Val Gln Ser Gly Pro Glu Glu Ile Asn Lys Arg Ile Glu 
            660                 665                 670         


His Thr Ile Asp Leu Arg Ser Gly Asp Lys Leu Arg Arg Glu His Ile 
        675                 680                 685             


Lys Pro Phe Ser Leu Met Phe Lys Asp Ser Ser Leu Glu His Lys Tyr 
    690                 695                 700                 


Ser Gln Met Arg Asp Glu Val Phe Lys Ser Asn Leu Val Cys Ala Phe 
705                 710                 715                 720 


Ile Val Leu Leu Phe Ile Thr Ala Ile Gln Ser Leu Leu Pro Ser Ser 
                725                 730                 735     


Arg Val Met Pro Met Thr Ile Gln Phe Ser Ile Leu Ile Met Leu His 
            740                 745                 750         


Ser Ala Leu Val Leu Ile Thr Thr Ala Glu Asp Tyr Lys Cys Leu Pro 
        755                 760                 765             


Leu Ile Leu Arg Lys Thr Cys Cys Trp Ile Asn Glu Thr Tyr Leu Ala 
    770                 775                 780                 


Arg Asn Val Ile Ile Phe Ala Ser Ile Leu Ile Asn Phe Leu Gly Ala 
785                 790                 795                 800 


Ile Leu Asn Ile Leu Trp Cys Asp Phe Asp Lys Ser Ile Pro Leu Lys 
                805                 810                 815     


Asn Leu Thr Phe Asn Ser Ser Ala Val Phe Thr Asp Ile Cys Ser Tyr 
            820                 825                 830         


Pro Glu Tyr Phe Val Phe Thr Gly Val Leu Ala Met Val Thr Cys Ala 
        835                 840                 845             


Val Phe Leu Arg Leu Asn Ser Val Leu Lys Leu Ala Val Leu Leu Ile 
    850                 855                 860                 


Met Ile Ala Ile Tyr Ala Leu Leu Thr Glu Thr Val Tyr Ala Gly Leu 
865                 870                 875                 880 


Phe Leu Arg Tyr Asp Asn Leu Asn His Ser Gly Glu Asp Phe Leu Gly 
                885                 890                 895     


Thr Lys Glu Val Ser Leu Leu Leu Met Ala Met Phe Leu Leu Ala Val 
            900                 905                 910         


Phe Tyr His Gly Gln Gln Leu Glu Tyr Thr Ala Arg Leu Asp Phe Leu 
        915                 920                 925             


Trp Arg Val Gln Ala Lys Glu Glu Ile Asn Glu Met Lys Glu Leu Arg 
    930                 935                 940                 


Glu His Asn Glu Asn Met Leu Arg Asn Ile Leu Pro Ser His Val Ala 
945                 950                 955                 960 


Arg His Phe Leu Glu Lys Asp Arg Asp Asn Glu Glu Leu Tyr Ser Gln 
                965                 970                 975     


Ser Tyr Asp Ala Val Gly Val Met Phe Ala Ser Ile Pro Gly Phe Ala 
            980                 985                 990         


Asp Phe Tyr Ser Gln Thr Glu Met  Asn Asn Gln Gly Val  Glu Cys Leu 
        995                 1000                 1005             


Arg Leu  Leu Asn Glu Ile Ile  Ala Asp Phe Asp Glu  Leu Leu Gly 
    1010                 1015                 1020             


Glu Asp  Arg Phe Gln Asp Ile  Glu Lys Ile Lys Thr  Ile Gly Ser 
    1025                 1030                 1035             


Thr Tyr  Met Ala Val Ser Gly  Leu Ser Pro Glu Lys  Gln Gln Cys 
    1040                 1045                 1050             


Glu Asp  Lys Trp Gly His Leu  Cys Ala Leu Ala Asp  Phe Ser Leu 
    1055                 1060                 1065             


Ala Leu  Thr Glu Ser Ile Gln  Glu Ile Asn Lys His  Ser Phe Asn 
    1070                 1075                 1080             


Asn Phe  Glu Leu Arg Ile Gly  Ile Ser His Gly Ser  Val Val Ala 
    1085                 1090                 1095             


Gly Val  Ile Gly Ala Lys Lys  Pro Gln Tyr Asp Ile  Trp Gly Lys 
    1100                 1105                 1110             


Thr Val  Asn Leu Ala Ser Arg  Met Asp Ser Thr Gly  Val Ser Gly 
    1115                 1120                 1125             


Arg Ile  Gln Val Pro Glu Glu  Thr Tyr Leu Ile Leu  Lys Asp Gln 
    1130                 1135                 1140             


Gly Phe  Ala Phe Asp Tyr Arg  Gly Glu Ile Tyr Val  Lys Gly Ile 
    1145                 1150                 1155             


Ser Glu  Gln Glu Gly Lys Ile  Lys Thr Tyr Phe Leu  Leu Gly Arg 
    1160                 1165                 1170             


Val Gln  Pro Asn Pro Phe Ile  Leu Pro Pro Arg Arg  Leu Pro Gly 
    1175                 1180                 1185             


Gln Tyr  Ser Leu Ala Ala Val  Val Leu Gly Leu Val  Gln Ser Leu 
    1190                 1195                 1200             


Asn Arg  Gln Arg Gln Lys Gln  Leu Leu Asn Glu Asn  Asn Asn Thr 
    1205                 1210                 1215             


Gly Ile  Ile Lys Gly His Tyr  Asn Arg Arg Thr Leu  Leu Ser Pro 
    1220                 1225                 1230             


Ser Gly  Thr Glu Pro Gly Ala  Gln Ala Glu Gly Thr  Asp Lys Ser 
    1235                 1240                 1245             


Asp Leu  Pro 
    1250     


<210>  1249
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  1249

Met Gly Gln Gly Asp Glu Ser Glu Arg Ile Val Ile Asn Val Gly Gly 
1               5                   10                  15      


Thr Arg His Gln Thr Tyr Arg Ser Thr Leu Arg Thr Leu Pro Gly Thr 
            20                  25                  30          


Arg Leu Ala Trp Leu Ala Glu Pro Asp Ala His Ser His Phe Asp Tyr 
        35                  40                  45              


Asp Pro Arg Ala Asp Glu Phe Phe Phe Asp Arg His Pro Gly Val Phe 
    50                  55                  60                  


Ala His Ile Leu Asn Tyr Tyr Arg Thr Gly Lys Leu His Cys Pro Ala 
65                  70                  75                  80  


Asp Val Cys Gly Pro Leu Tyr Glu Glu Glu Leu Ala Phe Trp Gly Ile 
                85                  90                  95      


Asp Glu Thr Asp Val Glu Pro Cys Cys Trp Met Thr Tyr Arg Gln His 
            100                 105                 110         


Arg Asp Ala Glu Glu Ala Leu Asp Ser Phe Gly Gly Ala Pro Leu Asp 
        115                 120                 125             


Asn Ser Ala Asp Asp Ala Asp Ala Asp Gly Pro Gly Asp Ser Gly Asp 
    130                 135                 140                 


Gly Glu Asp Glu Leu Glu Met Thr Lys Arg Leu Ala Leu Ser Asp Ser 
145                 150                 155                 160 


Pro Asp Gly Arg Pro Gly Gly Phe Trp Arg Arg Trp Gln Pro Arg Ile 
                165                 170                 175     


Trp Ala Leu Phe Glu Asp Pro Tyr Ser Ser Arg Tyr Ala Arg Tyr Val 
            180                 185                 190         


Ala Phe Ala Ser Leu Phe Phe Ile Leu Val Ser Ile Thr Thr Phe Cys 
        195                 200                 205             


Leu Glu Thr His Glu Arg Phe Asn Pro Ile Val Asn Lys Thr Glu Ile 
    210                 215                 220                 


Glu Asn Val Arg Asn Gly Thr Gln Val Arg Tyr Tyr Arg Glu Ala Glu 
225                 230                 235                 240 


Thr Glu Ala Phe Leu Thr Tyr Ile Glu Gly Val Cys Val Val Trp Phe 
                245                 250                 255     


Thr Phe Glu Phe Leu Met Arg Val Ile Phe Cys Pro Asn Lys Val Glu 
            260                 265                 270         


Phe Ile Lys Asn Ser Leu Asn Ile Ile Asp Phe Val Ala Ile Leu Pro 
        275                 280                 285             


Phe Tyr Leu Glu Val Gly Leu Ser Gly Leu Ser Ser Lys Ala Ala Lys 
    290                 295                 300                 


Asp Val Leu Gly Phe Leu Arg Val Val Arg Phe Val Arg Ile Leu Arg 
305                 310                 315                 320 


Ile Phe Lys Leu Thr Arg His Phe Val Gly Leu Arg Val Leu Gly His 
                325                 330                 335     


Thr Leu Arg Ala Ser Thr Asn Glu Phe Leu Leu Leu Ile Ile Phe Leu 
            340                 345                 350         


Ala Leu Gly Val Leu Ile Phe Ala Thr Met Ile Tyr Tyr Ala Glu Arg 
        355                 360                 365             


Ile Gly Ala Gln Pro Asn Asp Pro Ser Ala Ser Glu His Thr His Phe 
    370                 375                 380                 


Lys Asn Ile Pro Ile Gly Phe Trp Trp Ala Val Val Thr Met Thr Thr 
385                 390                 395                 400 


Leu Gly Tyr Gly Asp Met Tyr Pro Gln Thr Trp Ser Gly Met Leu Val 
                405                 410                 415     


Gly Ala Leu Cys Ala Leu Ala Gly Val Leu Thr Ile Ala Met Pro Val 
            420                 425                 430         


Pro Val Ile Val Asn Asn Phe Gly Met Tyr Tyr Ser Leu Ala Met Ala 
        435                 440                 445             


Lys Gln Lys Leu Pro Lys Lys Lys Lys Lys His Ile Pro Arg Pro Pro 
    450                 455                 460                 


Gln Leu Gly Ser Pro Asn Tyr Cys Lys Ser Val Val Asn Ser Pro His 
465                 470                 475                 480 


His Ser Thr Gln Ser Asp Thr Cys Pro Leu Ala Gln Glu Glu Ile Leu 
                485                 490                 495     


Glu Ile Asn Arg Ala Asp Ser Lys Leu Asn Gly Glu Val Ala Lys Ala 
            500                 505                 510         


Ala Leu Ala Asn Glu Asp Cys Pro His Ile Asp Gln Ala Leu Thr Pro 
        515                 520                 525             


Asp Glu Gly Leu Pro Phe Thr Arg Ser Gly Thr Arg Glu Arg Tyr Gly 
    530                 535                 540                 


Pro Cys Phe Leu Leu Ser Thr Gly Glu Tyr Ala Cys Pro Pro Gly Gly 
545                 550                 555                 560 


Gly Met Arg Lys Asp Leu Cys Lys Glu Ser Pro Val Ile Ala Lys Tyr 
                565                 570                 575     


Met Pro Thr Glu Ala Val Arg Val Thr 
            580                 585 


<210>  1250
<211>  968
<212>  PRT
<213>  Homo sapiens

<400>  1250

Met Tyr Asn Met Arg Arg Leu Ser Leu Ser Pro Thr Phe Ser Met Gly 
1               5                   10                  15      


Phe His Leu Leu Val Thr Val Ser Leu Leu Phe Ser His Val Asp His 
            20                  25                  30          


Val Ile Ala Glu Thr Glu Met Glu Gly Glu Gly Asn Glu Thr Gly Glu 
        35                  40                  45              


Cys Thr Gly Ser Tyr Tyr Cys Lys Lys Gly Val Ile Leu Pro Ile Trp 
    50                  55                  60                  


Glu Pro Gln Asp Pro Ser Phe Gly Asp Lys Ile Ala Arg Ala Thr Val 
65                  70                  75                  80  


Tyr Phe Val Ala Met Val Tyr Met Phe Leu Gly Val Ser Ile Ile Ala 
                85                  90                  95      


Asp Arg Phe Met Ser Ser Ile Glu Val Ile Thr Ser Gln Glu Lys Glu 
            100                 105                 110         


Ile Thr Ile Lys Lys Pro Asn Gly Glu Thr Thr Lys Thr Thr Val Arg 
        115                 120                 125             


Ile Trp Asn Glu Thr Val Ser Asn Leu Thr Leu Met Ala Leu Gly Ser 
    130                 135                 140                 


Ser Ala Pro Glu Ile Leu Leu Ser Val Ile Glu Val Cys Gly His Asn 
145                 150                 155                 160 


Phe Thr Ala Gly Asp Leu Gly Pro Ser Thr Ile Val Gly Ser Ala Ala 
                165                 170                 175     


Phe Asn Met Phe Ile Ile Ile Ala Leu Cys Val Tyr Val Val Pro Asp 
            180                 185                 190         


Gly Glu Thr Arg Lys Ile Lys His Leu Arg Val Phe Phe Val Thr Ala 
        195                 200                 205             


Ala Trp Ser Ile Phe Ala Tyr Thr Trp Leu Tyr Ile Ile Leu Ser Val 
    210                 215                 220                 


Ile Ser Pro Gly Val Val Glu Val Trp Glu Gly Leu Leu Thr Phe Phe 
225                 230                 235                 240 


Phe Phe Pro Ile Cys Val Val Phe Ala Trp Val Ala Asp Arg Arg Leu 
                245                 250                 255     


Leu Phe Tyr Lys Tyr Val Tyr Lys Arg Tyr Arg Ala Gly Lys Gln Arg 
            260                 265                 270         


Gly Met Ile Ile Glu His Glu Gly Asp Arg Pro Ser Ser Lys Thr Glu 
        275                 280                 285             


Ile Glu Met Asp Gly Lys Val Val Asn Ser His Val Glu Asn Phe Leu 
    290                 295                 300                 


Asp Gly Ala Leu Val Leu Glu Val Asp Glu Arg Asp Gln Asp Asp Glu 
305                 310                 315                 320 


Glu Ala Arg Arg Glu Met Ala Arg Ile Leu Lys Glu Leu Lys Gln Lys 
                325                 330                 335     


His Pro Asp Lys Glu Ile Glu Gln Leu Ile Glu Leu Ala Asn Tyr Gln 
            340                 345                 350         


Val Leu Ser Gln Gln Gln Lys Ser Arg Ala Phe Tyr Arg Ile Gln Ala 
        355                 360                 365             


Thr Arg Leu Met Thr Gly Ala Gly Asn Ile Leu Lys Arg His Ala Ala 
    370                 375                 380                 


Asp Gln Ala Arg Lys Ala Val Ser Met His Glu Val Asn Thr Glu Val 
385                 390                 395                 400 


Thr Glu Asn Asp Pro Val Ser Lys Ile Phe Phe Glu Gln Gly Thr Tyr 
                405                 410                 415     


Gln Cys Leu Glu Asn Cys Gly Thr Val Ala Leu Thr Ile Ile Arg Arg 
            420                 425                 430         


Gly Gly Asp Leu Thr Asn Thr Val Phe Val Asp Phe Arg Thr Glu Asp 
        435                 440                 445             


Gly Thr Ala Asn Ala Gly Ser Asp Tyr Glu Phe Thr Glu Gly Thr Val 
    450                 455                 460                 


Val Phe Lys Pro Gly Asp Thr Gln Lys Glu Ile Arg Val Gly Ile Ile 
465                 470                 475                 480 


Asp Asp Asp Ile Phe Glu Glu Asp Glu Asn Phe Leu Val His Leu Ser 
                485                 490                 495     


Asn Val Lys Val Ser Ser Glu Ala Ser Glu Asp Gly Ile Leu Glu Ala 
            500                 505                 510         


Asn His Val Ser Thr Leu Ala Cys Leu Gly Ser Pro Ser Thr Ala Thr 
        515                 520                 525             


Val Thr Ile Phe Asp Asp Asp His Ala Gly Ile Phe Thr Phe Glu Glu 
    530                 535                 540                 


Pro Val Thr His Val Ser Glu Ser Ile Gly Ile Met Glu Val Lys Val 
545                 550                 555                 560 


Leu Arg Thr Ser Gly Ala Arg Gly Asn Val Ile Val Pro Tyr Lys Thr 
                565                 570                 575     


Ile Glu Gly Thr Ala Arg Gly Gly Gly Glu Asp Phe Glu Asp Thr Cys 
            580                 585                 590         


Gly Glu Leu Glu Phe Gln Asn Asp Glu Ile Val Lys Thr Ile Ser Val 
        595                 600                 605             


Lys Val Ile Asp Asp Glu Glu Tyr Glu Lys Asn Lys Thr Phe Phe Leu 
    610                 615                 620                 


Glu Ile Gly Glu Pro Arg Leu Val Glu Met Ser Glu Lys Lys Ala Leu 
625                 630                 635                 640 


Leu Leu Asn Glu Leu Gly Gly Phe Thr Ile Thr Gly Gln Pro Val Phe 
                645                 650                 655     


Arg Lys Val His Ala Arg Glu His Pro Ile Leu Ser Thr Val Ile Thr 
            660                 665                 670         


Ile Ala Asp Glu Tyr Asp Asp Lys Gln Pro Leu Thr Ser Lys Glu Glu 
        675                 680                 685             


Glu Glu Arg Arg Ile Ala Glu Met Gly Arg Pro Ile Leu Gly Glu His 
    690                 695                 700                 


Thr Lys Leu Glu Val Ile Ile Glu Glu Ser Tyr Glu Phe Lys Ser Thr 
705                 710                 715                 720 


Val Asp Lys Leu Ile Lys Lys Thr Asn Leu Ala Leu Val Val Gly Thr 
                725                 730                 735     


Asn Ser Trp Arg Glu Gln Phe Ile Glu Ala Ile Thr Val Ser Ala Gly 
            740                 745                 750         


Glu Asp Asp Asp Asp Asp Glu Cys Gly Glu Glu Lys Leu Pro Ser Cys 
        755                 760                 765             


Phe Asp Tyr Val Met His Phe Leu Thr Val Phe Trp Lys Val Leu Phe 
    770                 775                 780                 


Ala Phe Val Pro Pro Thr Glu Tyr Trp Asn Gly Trp Ala Cys Phe Ile 
785                 790                 795                 800 


Val Ser Ile Leu Met Ile Gly Leu Leu Thr Ala Phe Ile Gly Asp Leu 
                805                 810                 815     


Ala Ser His Phe Gly Cys Thr Ile Gly Leu Lys Asp Ser Val Thr Ala 
            820                 825                 830         


Val Val Phe Val Ala Leu Gly Thr Ser Val Pro Asp Thr Phe Ala Ser 
        835                 840                 845             


Lys Val Ala Ala Thr Gln Asp Gln Tyr Ala Asp Ala Ser Ile Gly Asn 
    850                 855                 860                 


Val Thr Gly Ser Asn Ala Val Asn Val Phe Leu Gly Ile Gly Val Ala 
865                 870                 875                 880 


Trp Ser Ile Ala Ala Ile Tyr His Ala Ala Asn Gly Glu Gln Phe Lys 
                885                 890                 895     


Val Ser Pro Gly Thr Leu Ala Phe Ser Val Thr Leu Phe Thr Ile Phe 
            900                 905                 910         


Ala Phe Ile Asn Val Gly Val Leu Leu Tyr Arg Arg Arg Pro Glu Ile 
        915                 920                 925             


Gly Gly Glu Leu Gly Gly Pro Arg Thr Ala Lys Leu Leu Thr Ser Cys 
    930                 935                 940                 


Leu Phe Val Leu Leu Trp Leu Leu Tyr Ile Phe Phe Ser Ser Leu Glu 
945                 950                 955                 960 


Ala Tyr Cys His Ile Lys Gly Phe 
                965             


<210>  1251
<211>  960
<212>  PRT
<213>  Homo sapiens

<400>  1251

Met Tyr Asn Met Arg Arg Leu Ser Leu Ser Pro Thr Phe Ser Met Gly 
1               5                   10                  15      


Phe His Leu Leu Val Thr Val Ser Leu Leu Phe Ser His Val Asp His 
            20                  25                  30          


Val Ile Ala Glu Thr Glu Met Glu Gly Glu Gly Asn Glu Thr Gly Glu 
        35                  40                  45              


Cys Thr Gly Ser Tyr Tyr Cys Lys Lys Gly Val Ile Leu Pro Ile Trp 
    50                  55                  60                  


Glu Pro Gln Asp Pro Ser Phe Gly Asp Lys Ile Ala Arg Ala Thr Val 
65                  70                  75                  80  


Tyr Phe Val Ala Met Val Tyr Met Phe Leu Gly Val Ser Ile Ile Ala 
                85                  90                  95      


Asp Arg Phe Met Ser Ser Ile Glu Val Ile Thr Ser Gln Glu Lys Glu 
            100                 105                 110         


Ile Thr Ile Lys Lys Pro Asn Gly Glu Thr Thr Lys Thr Thr Val Arg 
        115                 120                 125             


Ile Trp Asn Glu Thr Val Ser Asn Leu Thr Leu Met Ala Leu Gly Ser 
    130                 135                 140                 


Ser Ala Pro Glu Ile Leu Leu Ser Val Ile Glu Val Cys Gly His Asn 
145                 150                 155                 160 


Phe Thr Ala Gly Asp Leu Gly Pro Ser Thr Ile Val Gly Ser Ala Ala 
                165                 170                 175     


Phe Asn Met Phe Ile Ile Ile Ala Leu Cys Val Tyr Val Val Pro Asp 
            180                 185                 190         


Gly Glu Thr Arg Lys Ile Lys His Leu Arg Val Phe Phe Val Thr Ala 
        195                 200                 205             


Ala Trp Ser Ile Phe Ala Tyr Thr Trp Leu Tyr Ile Ile Leu Ser Val 
    210                 215                 220                 


Ile Ser Pro Gly Val Val Glu Val Trp Glu Gly Leu Leu Thr Phe Phe 
225                 230                 235                 240 


Phe Phe Pro Ile Cys Val Val Phe Ala Trp Val Ala Asp Arg Arg Leu 
                245                 250                 255     


Leu Phe Tyr Lys Tyr Val Tyr Lys Arg Tyr Arg Ala Gly Lys Gln Arg 
            260                 265                 270         


Gly Met Ile Ile Glu His Glu Gly Asp Arg Pro Ser Ser Lys Thr Glu 
        275                 280                 285             


Ile Glu Met Asp Gly Lys Val Val Asn Ser His Val Glu Asn Phe Leu 
    290                 295                 300                 


Asp Gly Ala Leu Val Leu Glu Val Asp Glu Arg Asp Gln Asp Asp Glu 
305                 310                 315                 320 


Glu Ala Arg Arg Glu Met Ala Arg Ile Leu Lys Glu Leu Lys Gln Lys 
                325                 330                 335     


His Pro Asp Lys Glu Ile Glu Gln Leu Ile Glu Leu Ala Asn Tyr Gln 
            340                 345                 350         


Val Leu Ser Gln Gln Gln Lys Ser Arg Ala Phe Tyr Arg Ile Gln Ala 
        355                 360                 365             


Thr Arg Leu Met Thr Gly Ala Gly Asn Ile Leu Lys Arg His Ala Ala 
    370                 375                 380                 


Asp Gln Ala Arg Lys Ala Val Ser Met His Glu Val Asn Thr Glu Val 
385                 390                 395                 400 


Thr Glu Asn Asp Pro Val Ser Lys Ile Phe Phe Glu Gln Gly Thr Tyr 
                405                 410                 415     


Gln Cys Leu Glu Asn Cys Gly Thr Val Ala Leu Thr Ile Ile Arg Arg 
            420                 425                 430         


Gly Gly Asp Leu Thr Asn Thr Val Phe Val Asp Phe Arg Thr Glu Asp 
        435                 440                 445             


Gly Thr Ala Asn Ala Gly Ser Asp Tyr Glu Phe Thr Glu Gly Thr Val 
    450                 455                 460                 


Val Phe Lys Pro Gly Asp Thr Gln Lys Glu Ile Arg Val Gly Ile Ile 
465                 470                 475                 480 


Asp Asp Asp Ile Phe Glu Glu Asp Glu Asn Phe Leu Val His Leu Ser 
                485                 490                 495     


Asn Val Lys Val Ser Ser Glu Ala Ser Glu Asp Gly Ile Leu Glu Ala 
            500                 505                 510         


Asn His Val Ser Thr Leu Ala Cys Leu Gly Ser Pro Ser Thr Ala Thr 
        515                 520                 525             


Val Thr Ile Phe Asp Asp Asp His Ala Gly Ile Phe Thr Phe Glu Glu 
    530                 535                 540                 


Pro Val Thr His Val Ser Glu Ser Ile Gly Ile Met Glu Val Lys Val 
545                 550                 555                 560 


Leu Arg Thr Ser Gly Ala Arg Gly Asn Val Ile Val Pro Tyr Lys Thr 
                565                 570                 575     


Ile Glu Gly Thr Ala Arg Gly Gly Gly Glu Asp Phe Glu Asp Thr Cys 
            580                 585                 590         


Gly Glu Leu Glu Phe Gln Asn Asp Glu Ile Val Lys Ile Ile Thr Ile 
        595                 600                 605             


Arg Ile Phe Asp Arg Glu Glu Tyr Glu Lys Glu Cys Ser Phe Ser Leu 
    610                 615                 620                 


Val Leu Glu Glu Pro Lys Trp Ile Arg Arg Gly Met Lys Gly Gly Phe 
625                 630                 635                 640 


Thr Ile Thr Gly Gln Pro Val Phe Arg Lys Val His Ala Arg Glu His 
                645                 650                 655     


Pro Ile Leu Ser Thr Val Ile Thr Ile Ala Asp Glu Tyr Asp Asp Lys 
            660                 665                 670         


Gln Pro Leu Thr Ser Lys Glu Glu Glu Glu Arg Arg Ile Ala Glu Met 
        675                 680                 685             


Gly Arg Pro Ile Leu Gly Glu His Thr Lys Leu Glu Val Ile Ile Glu 
    690                 695                 700                 


Glu Ser Tyr Glu Phe Lys Ser Thr Val Asp Lys Leu Ile Lys Lys Thr 
705                 710                 715                 720 


Asn Leu Ala Leu Val Val Gly Thr Asn Ser Trp Arg Glu Gln Phe Ile 
                725                 730                 735     


Glu Ala Ile Thr Val Ser Ala Gly Glu Asp Asp Asp Asp Asp Glu Cys 
            740                 745                 750         


Gly Glu Glu Lys Leu Pro Ser Cys Phe Asp Tyr Val Met His Phe Leu 
        755                 760                 765             


Thr Val Phe Trp Lys Val Leu Phe Ala Phe Val Pro Pro Thr Glu Tyr 
    770                 775                 780                 


Trp Asn Gly Trp Ala Cys Phe Ile Val Ser Ile Leu Met Ile Gly Leu 
785                 790                 795                 800 


Leu Thr Ala Phe Ile Gly Asp Leu Ala Ser His Phe Gly Cys Thr Ile 
                805                 810                 815     


Gly Leu Lys Asp Ser Val Thr Ala Val Val Phe Val Ala Leu Gly Thr 
            820                 825                 830         


Ser Val Pro Asp Thr Phe Ala Ser Lys Val Ala Ala Thr Gln Asp Gln 
        835                 840                 845             


Tyr Ala Asp Ala Ser Ile Gly Asn Val Thr Gly Ser Asn Ala Val Asn 
    850                 855                 860                 


Val Phe Leu Gly Ile Gly Val Ala Trp Ser Ile Ala Ala Ile Tyr His 
865                 870                 875                 880 


Ala Ala Asn Gly Glu Gln Phe Lys Val Ser Pro Gly Thr Leu Ala Phe 
                885                 890                 895     


Ser Val Thr Leu Phe Thr Ile Phe Ala Phe Ile Asn Val Gly Val Leu 
            900                 905                 910         


Leu Tyr Arg Arg Arg Pro Glu Ile Gly Gly Glu Leu Gly Gly Pro Arg 
        915                 920                 925             


Thr Ala Lys Leu Leu Thr Ser Cys Leu Phe Val Leu Leu Trp Leu Leu 
    930                 935                 940                 


Tyr Ile Phe Phe Ser Ser Leu Glu Ala Tyr Cys His Ile Lys Gly Phe 
945                 950                 955                 960 


<210>  1252
<211>  937
<212>  PRT
<213>  Homo sapiens

<400>  1252

Met Tyr Asn Met Arg Arg Leu Ser Leu Ser Pro Thr Phe Ser Met Gly 
1               5                   10                  15      


Phe His Leu Leu Val Thr Val Ser Leu Leu Phe Ser His Val Asp His 
            20                  25                  30          


Val Ile Ala Glu Thr Glu Met Glu Gly Glu Gly Asn Glu Thr Gly Glu 
        35                  40                  45              


Cys Thr Gly Ser Tyr Tyr Cys Lys Lys Gly Val Ile Leu Pro Ile Trp 
    50                  55                  60                  


Glu Pro Gln Asp Pro Ser Phe Gly Asp Lys Ile Ala Arg Ala Thr Val 
65                  70                  75                  80  


Tyr Phe Val Ala Met Val Tyr Met Phe Leu Gly Val Ser Ile Ile Ala 
                85                  90                  95      


Asp Arg Phe Met Ser Ser Ile Glu Val Ile Thr Ser Gln Glu Lys Glu 
            100                 105                 110         


Ile Thr Ile Lys Lys Pro Asn Gly Glu Thr Thr Lys Thr Thr Val Arg 
        115                 120                 125             


Ile Trp Asn Glu Thr Val Ser Asn Leu Thr Leu Met Ala Leu Gly Ser 
    130                 135                 140                 


Ser Ala Pro Glu Ile Leu Leu Ser Val Ile Glu Val Cys Gly His Asn 
145                 150                 155                 160 


Phe Thr Ala Gly Asp Leu Gly Pro Ser Thr Ile Val Gly Ser Ala Ala 
                165                 170                 175     


Phe Asn Met Phe Ile Ile Ile Ala Leu Cys Val Tyr Val Val Pro Asp 
            180                 185                 190         


Gly Glu Thr Arg Lys Ile Lys His Leu Arg Val Phe Phe Val Thr Ala 
        195                 200                 205             


Ala Trp Ser Ile Phe Ala Tyr Thr Trp Leu Tyr Ile Ile Leu Ser Val 
    210                 215                 220                 


Ile Ser Pro Gly Val Val Glu Val Trp Glu Gly Leu Leu Thr Phe Phe 
225                 230                 235                 240 


Phe Phe Pro Ile Cys Val Val Phe Ala Trp Val Ala Asp Arg Arg Leu 
                245                 250                 255     


Leu Phe Tyr Lys Tyr Val Tyr Lys Arg Tyr Arg Ala Gly Lys Gln Arg 
            260                 265                 270         


Gly Met Ile Ile Glu His Glu Gly Asp Arg Pro Ser Ser Lys Thr Glu 
        275                 280                 285             


Ile Glu Met Asp Gly Lys Val Val Asn Ser His Val Glu Asn Phe Leu 
    290                 295                 300                 


Asp Gly Ala Leu Val Leu Glu Val Asp Glu Arg Asp Gln Asp Asp Glu 
305                 310                 315                 320 


Glu Ala Arg Arg Glu Met Ala Arg Ile Leu Lys Glu Leu Lys Gln Lys 
                325                 330                 335     


His Pro Asp Lys Glu Ile Glu Gln Leu Ile Glu Leu Ala Asn Tyr Gln 
            340                 345                 350         


Val Leu Ser Gln Gln Gln Lys Ser Arg Ala Phe Tyr Arg Ile Gln Ala 
        355                 360                 365             


Thr Arg Leu Met Thr Gly Ala Gly Asn Ile Leu Lys Arg His Ala Ala 
    370                 375                 380                 


Asp Gln Ala Arg Lys Ala Val Ser Met His Glu Val Asn Thr Glu Val 
385                 390                 395                 400 


Thr Glu Asn Asp Pro Val Ser Lys Ile Phe Phe Glu Gln Gly Thr Tyr 
                405                 410                 415     


Gln Cys Leu Glu Asn Cys Gly Thr Val Ala Leu Thr Ile Ile Arg Arg 
            420                 425                 430         


Gly Gly Asp Leu Thr Asn Thr Val Phe Val Asp Phe Arg Thr Glu Asp 
        435                 440                 445             


Gly Thr Ala Asn Ala Gly Ser Asp Tyr Glu Phe Thr Glu Gly Thr Val 
    450                 455                 460                 


Val Phe Lys Pro Gly Asp Thr Gln Lys Glu Ile Arg Val Gly Ile Ile 
465                 470                 475                 480 


Asp Asp Asp Ile Phe Glu Glu Asp Glu Asn Phe Leu Val His Leu Ser 
                485                 490                 495     


Asn Val Lys Val Ser Ser Glu Ala Ser Glu Asp Gly Ile Leu Glu Ala 
            500                 505                 510         


Asn His Val Ser Thr Leu Ala Cys Leu Gly Ser Pro Ser Thr Ala Thr 
        515                 520                 525             


Val Thr Ile Phe Asp Asp Asp His Ala Gly Ile Phe Thr Phe Glu Glu 
    530                 535                 540                 


Pro Val Thr His Val Ser Glu Ser Ile Gly Ile Met Glu Val Lys Val 
545                 550                 555                 560 


Leu Arg Thr Ser Gly Ala Arg Gly Asn Val Ile Val Pro Tyr Lys Thr 
                565                 570                 575     


Ile Glu Gly Thr Ala Arg Gly Gly Gly Glu Asp Phe Glu Asp Thr Cys 
            580                 585                 590         


Gly Glu Leu Glu Phe Gln Asn Asp Glu Ile Val Lys Ile Ile Thr Ile 
        595                 600                 605             


Arg Ile Phe Asp Arg Glu Glu Tyr Glu Lys Glu Cys Ser Phe Ser Leu 
    610                 615                 620                 


Val Leu Glu Glu Pro Lys Trp Ile Arg Arg Gly Met Lys Gly Gly Phe 
625                 630                 635                 640 


Thr Ile Thr Asp Glu Tyr Asp Asp Lys Gln Pro Leu Thr Ser Lys Glu 
                645                 650                 655     


Glu Glu Glu Arg Arg Ile Ala Glu Met Gly Arg Pro Ile Leu Gly Glu 
            660                 665                 670         


His Thr Lys Leu Glu Val Ile Ile Glu Glu Ser Tyr Glu Phe Lys Ser 
        675                 680                 685             


Thr Val Asp Lys Leu Ile Lys Lys Thr Asn Leu Ala Leu Val Val Gly 
    690                 695                 700                 


Thr Asn Ser Trp Arg Glu Gln Phe Ile Glu Ala Ile Thr Val Ser Ala 
705                 710                 715                 720 


Gly Glu Asp Asp Asp Asp Asp Glu Cys Gly Glu Glu Lys Leu Pro Ser 
                725                 730                 735     


Cys Phe Asp Tyr Val Met His Phe Leu Thr Val Phe Trp Lys Val Leu 
            740                 745                 750         


Phe Ala Phe Val Pro Pro Thr Glu Tyr Trp Asn Gly Trp Ala Cys Phe 
        755                 760                 765             


Ile Val Ser Ile Leu Met Ile Gly Leu Leu Thr Ala Phe Ile Gly Asp 
    770                 775                 780                 


Leu Ala Ser His Phe Gly Cys Thr Ile Gly Leu Lys Asp Ser Val Thr 
785                 790                 795                 800 


Ala Val Val Phe Val Ala Leu Gly Thr Ser Val Pro Asp Thr Phe Ala 
                805                 810                 815     


Ser Lys Val Ala Ala Thr Gln Asp Gln Tyr Ala Asp Ala Ser Ile Gly 
            820                 825                 830         


Asn Val Thr Gly Ser Asn Ala Val Asn Val Phe Leu Gly Ile Gly Val 
        835                 840                 845             


Ala Trp Ser Ile Ala Ala Ile Tyr His Ala Ala Asn Gly Glu Gln Phe 
    850                 855                 860                 


Lys Val Ser Pro Gly Thr Leu Ala Phe Ser Val Thr Leu Phe Thr Ile 
865                 870                 875                 880 


Phe Ala Phe Ile Asn Val Gly Val Leu Leu Tyr Arg Arg Arg Pro Glu 
                885                 890                 895     


Ile Gly Gly Glu Leu Gly Gly Pro Arg Thr Ala Lys Leu Leu Thr Ser 
            900                 905                 910         


Cys Leu Phe Val Leu Leu Trp Leu Leu Tyr Ile Phe Phe Ser Ser Leu 
        915                 920                 925             


Glu Ala Tyr Cys His Ile Lys Gly Phe 
    930                 935         


<210>  1253
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  1253

Met Arg Ile Ile Ser Arg Gln Ile Val Leu Leu Phe Ser Gly Phe Trp 
1               5                   10                  15      


Gly Leu Ala Met Gly Ala Phe Pro Ser Ser Val Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Ile Arg Asn Thr Asp Gln Glu Tyr Thr Ala Phe Arg Leu Ala Ile 
        35                  40                  45              


Phe Leu His Asn Thr Ser Pro Asn Ala Ser Glu Ala Pro Phe Asn Leu 
    50                  55                  60                  


Val Pro His Val Asp Asn Ile Glu Thr Ala Asn Ser Phe Ala Val Thr 
65                  70                  75                  80  


Asn Ala Phe Cys Ser Gln Tyr Ser Arg Gly Val Phe Ala Ile Phe Gly 
                85                  90                  95      


Leu Tyr Asp Lys Arg Ser Val His Thr Leu Thr Ser Phe Cys Ser Ala 
            100                 105                 110         


Leu His Ile Ser Leu Ile Thr Pro Ser Phe Pro Thr Glu Gly Glu Ser 
        115                 120                 125             


Gln Phe Val Leu Gln Leu Arg Pro Ser Leu Arg Gly Ala Leu Leu Ser 
    130                 135                 140                 


Leu Leu Asp His Tyr Glu Trp Asn Cys Phe Val Phe Leu Tyr Asp Thr 
145                 150                 155                 160 


Asp Arg Gly Tyr Ser Ile Leu Gln Ala Ile Met Glu Lys Ala Gly Gln 
                165                 170                 175     


Asn Gly Trp His Val Ser Ala Ile Cys Val Glu Asn Phe Asn Asp Val 
            180                 185                 190         


Ser Tyr Arg Gln Leu Leu Glu Glu Leu Asp Arg Arg Gln Glu Lys Lys 
        195                 200                 205             


Phe Val Ile Asp Cys Glu Ile Glu Arg Leu Gln Asn Ile Leu Glu Gln 
    210                 215                 220                 


Ile Val Ser Val Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala 
225                 230                 235                 240 


Asn Leu Gly Phe Lys Asp Ile Ser Leu Glu Arg Phe Ile His Gly Gly 
                245                 250                 255     


Ala Asn Val Thr Gly Phe Gln Leu Val Asp Phe Asn Thr Pro Met Val 
            260                 265                 270         


Ile Lys Leu Met Asp Arg Trp Lys Lys Leu Asp Gln Arg Glu Tyr Pro 
        275                 280                 285             


Gly Ser Glu Thr Pro Pro Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Gly 
    290                 295                 300                 


Val Leu Val Met Ala Glu Thr Phe Arg Ser Leu Arg Arg Gln Lys Ile 
305                 310                 315                 320 


Asp Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala 
                325                 330                 335     


Ala Pro Trp Gly Gln Gly Ile Asp Met Glu Arg Thr Leu Lys Gln Val 
            340                 345                 350         


Arg Ile Gln Gly Leu Thr Gly Asn Val Gln Phe Asp His Tyr Gly Arg 
        355                 360                 365             


Arg Val Asn Tyr Thr Met Asp Val Phe Glu Leu Lys Ser Thr Gly Pro 
    370                 375                 380                 


Arg Lys Val Gly Tyr Trp Asn Asp Met Asp Lys Leu Val Leu Ile Gln 
385                 390                 395                 400 


Asp Val Pro Thr Leu Gly Asn Asp Thr Ala Ala Ile Glu Asn Arg Thr 
                405                 410                 415     


Val Val Val Thr Thr Ile Met Pro Leu Met Lys Asn Pro Ile Leu Arg 
            420                 425                 430         


Asn 
    


<210>  1254
<211>  758
<212>  PRT
<213>  Homo sapiens

<400>  1254

Met Pro Leu Gln Gly Leu Gly Leu Gln Arg Asn Pro Phe Leu Gln Gly 
1               5                   10                  15      


Lys Arg Gly Pro Gly Leu Thr Ser Ser Pro Pro Leu Leu Pro Pro Ser 
            20                  25                  30          


Leu Gln Val Asn Phe His Ser Pro Arg Ser Gly Gln Arg Cys Trp Ala 
        35                  40                  45              


Ala Arg Thr Gln Val Glu Lys Arg Leu Val Val Leu Val Val Leu Leu 
    50                  55                  60                  


Ala Ala Gly Leu Val Ala Cys Leu Ala Ala Leu Gly Ile Gln Tyr Gln 
65                  70                  75                  80  


Thr Arg Ser Pro Ser Val Cys Leu Ser Glu Ala Cys Val Ser Val Thr 
                85                  90                  95      


Ser Ser Ile Leu Ser Ser Met Asp Pro Thr Val Asp Pro Cys His Asp 
            100                 105                 110         


Phe Phe Ser Tyr Ala Cys Gly Gly Trp Ile Lys Ala Asn Pro Val Pro 
        115                 120                 125             


Asp Gly His Ser Arg Trp Gly Thr Phe Ser Asn Leu Trp Glu His Asn 
    130                 135                 140                 


Gln Ala Ile Ile Lys His Leu Leu Glu Asn Ser Thr Ala Ser Val Ser 
145                 150                 155                 160 


Glu Ala Glu Arg Lys Ala Gln Val Tyr Tyr Arg Ala Cys Met Asn Glu 
                165                 170                 175     


Thr Arg Ile Glu Glu Leu Arg Ala Lys Pro Leu Met Glu Leu Ile Glu 
            180                 185                 190         


Arg Leu Gly Gly Trp Asn Ile Thr Gly Pro Trp Ala Lys Asp Asn Phe 
        195                 200                 205             


Gln Asp Thr Leu Gln Val Val Thr Ala His Tyr Arg Thr Ser Pro Phe 
    210                 215                 220                 


Phe Ser Val Tyr Val Ser Ala Asp Ser Lys Asn Ser Asn Ser Asn Val 
225                 230                 235                 240 


Ile Gln Val Asp Gln Ser Gly Leu Gly Leu Pro Ser Arg Asp Tyr Tyr 
                245                 250                 255     


Leu Asn Lys Thr Glu Asn Glu Lys Val Leu Thr Gly Tyr Leu Asn Tyr 
            260                 265                 270         


Met Val Gln Leu Gly Lys Leu Leu Gly Gly Gly Asp Glu Glu Ala Ile 
        275                 280                 285             


Arg Pro Gln Met Gln Gln Ile Leu Asp Phe Glu Thr Ala Leu Ala Asn 
    290                 295                 300                 


Ile Thr Ile Pro Gln Glu Lys Arg Arg Asp Glu Glu Leu Ile Tyr His 
305                 310                 315                 320 


Lys Val Thr Ala Ala Glu Leu Gln Thr Leu Ala Pro Ala Ile Asn Trp 
                325                 330                 335     


Leu Pro Phe Leu Asn Thr Ile Phe Tyr Pro Val Glu Ile Asn Glu Ser 
            340                 345                 350         


Glu Pro Ile Val Val Tyr Asp Lys Glu Tyr Leu Glu Gln Ile Ser Thr 
        355                 360                 365             


Leu Ile Asn Thr Thr Asp Arg Cys Leu Leu Asn Asn Tyr Met Ile Trp 
    370                 375                 380                 


Asn Leu Val Arg Lys Thr Ser Ser Phe Leu Asp Gln Arg Phe Gln Asp 
385                 390                 395                 400 


Ala Asp Glu Lys Phe Met Glu Val Met Tyr Gly Thr Lys Lys Thr Cys 
                405                 410                 415     


Leu Pro Arg Trp Lys Phe Cys Val Ser Asp Thr Glu Asn Asn Leu Gly 
            420                 425                 430         


Phe Ala Leu Gly Pro Met Phe Val Lys Ala Thr Phe Ala Glu Asp Ser 
        435                 440                 445             


Lys Ser Ile Ala Thr Glu Ile Ile Leu Glu Ile Lys Lys Ala Phe Glu 
    450                 455                 460                 


Glu Ser Leu Ser Thr Leu Lys Trp Met Asp Glu Glu Thr Arg Lys Ser 
465                 470                 475                 480 


Ala Lys Glu Lys Ala Asp Ala Ile Tyr Asn Met Ile Gly Tyr Pro Asn 
                485                 490                 495     


Phe Ile Met Asp Pro Lys Glu Leu Asp Lys Val Phe Asn Asp Tyr Thr 
            500                 505                 510         


Ala Val Pro Asp Leu Tyr Phe Glu Asn Ala Met Arg Phe Phe Asn Phe 
        515                 520                 525             


Ser Trp Arg Val Thr Ala Asp Gln Leu Arg Lys Ala Pro Asn Arg Asp 
    530                 535                 540                 


Gln Trp Ser Met Thr Pro Pro Met Val Asn Ala Tyr Tyr Ser Pro Thr 
545                 550                 555                 560 


Lys Asn Glu Ile Val Phe Pro Ala Gly Ile Leu Gln Ala Pro Phe Tyr 
                565                 570                 575     


Thr Arg Ser Ser Pro Lys Ala Leu Asn Phe Gly Gly Ile Gly Val Val 
            580                 585                 590         


Val Gly His Glu Leu Thr His Ala Phe Asp Asp Gln Gly Arg Glu Tyr 
        595                 600                 605             


Asp Lys Asp Gly Asn Leu Arg Pro Trp Trp Lys Asn Ser Ser Val Glu 
    610                 615                 620                 


Ala Phe Lys Arg Gln Thr Glu Cys Met Val Glu Gln Tyr Ser Asn Tyr 
625                 630                 635                 640 


Ser Val Asn Gly Glu Pro Val Asn Gly Arg His Thr Leu Gly Glu Asn 
                645                 650                 655     


Ile Ala Asp Asn Gly Gly Leu Lys Ala Ala Tyr Arg Ala Tyr Gln Asn 
            660                 665                 670         


Trp Val Lys Lys Asn Gly Ala Glu His Ser Leu Pro Thr Leu Gly Leu 
        675                 680                 685             


Thr Asn Asn Gln Leu Phe Phe Leu Gly Phe Ala Gln Val Trp Cys Ser 
    690                 695                 700                 


Val Arg Thr Pro Glu Ser Ser His Glu Gly Leu Ile Thr Asp Pro His 
705                 710                 715                 720 


Ser Pro Ser Arg Phe Arg Val Ile Gly Ser Leu Ser Asn Ser Lys Glu 
                725                 730                 735     


Phe Ser Glu His Phe Arg Cys Pro Pro Gly Ser Pro Met Asn Pro Pro 
            740                 745                 750         


His Lys Cys Glu Val Trp 
        755             


<210>  1255
<211>  754
<212>  PRT
<213>  Homo sapiens

<400>  1255

Met Met Ser Thr Tyr Lys Arg Ala Thr Leu Asp Glu Glu Asp Leu Val 
1               5                   10                  15      


Asp Ser Leu Ser Glu Gly Asp Ala Tyr Pro Asn Gly Leu Gln Val Asn 
            20                  25                  30          


Phe His Ser Pro Arg Ser Gly Gln Arg Cys Trp Ala Ala Arg Thr Gln 
        35                  40                  45              


Val Glu Lys Arg Leu Val Val Leu Val Val Leu Leu Ala Ala Gly Leu 
    50                  55                  60                  


Val Ala Cys Leu Ala Ala Leu Gly Ile Gln Tyr Gln Thr Arg Ser Pro 
65                  70                  75                  80  


Ser Val Cys Leu Ser Glu Ala Cys Val Ser Val Thr Ser Ser Ile Leu 
                85                  90                  95      


Ser Ser Met Asp Pro Thr Val Asp Pro Cys His Asp Phe Phe Ser Tyr 
            100                 105                 110         


Ala Cys Gly Gly Trp Ile Lys Ala Asn Pro Val Pro Asp Gly His Ser 
        115                 120                 125             


Arg Trp Gly Thr Phe Ser Asn Leu Trp Glu His Asn Gln Ala Ile Ile 
    130                 135                 140                 


Lys His Leu Leu Glu Asn Ser Thr Ala Ser Val Ser Glu Ala Glu Arg 
145                 150                 155                 160 


Lys Ala Gln Val Tyr Tyr Arg Ala Cys Met Asn Glu Thr Arg Ile Glu 
                165                 170                 175     


Glu Leu Arg Ala Lys Pro Leu Met Glu Leu Ile Glu Arg Leu Gly Gly 
            180                 185                 190         


Trp Asn Ile Thr Gly Pro Trp Ala Lys Asp Asn Phe Gln Asp Thr Leu 
        195                 200                 205             


Gln Val Val Thr Ala His Tyr Arg Thr Ser Pro Phe Phe Ser Val Tyr 
    210                 215                 220                 


Val Ser Ala Asp Ser Lys Asn Ser Asn Ser Asn Val Ile Gln Val Asp 
225                 230                 235                 240 


Gln Ser Gly Leu Gly Leu Pro Ser Arg Asp Tyr Tyr Leu Asn Lys Thr 
                245                 250                 255     


Glu Asn Glu Lys Val Leu Thr Gly Tyr Leu Asn Tyr Met Val Gln Leu 
            260                 265                 270         


Gly Lys Leu Leu Gly Gly Gly Asp Glu Glu Ala Ile Arg Pro Gln Met 
        275                 280                 285             


Gln Gln Ile Leu Asp Phe Glu Thr Ala Leu Ala Asn Ile Thr Ile Pro 
    290                 295                 300                 


Gln Glu Lys Arg Arg Asp Glu Glu Leu Ile Tyr His Lys Val Thr Ala 
305                 310                 315                 320 


Ala Glu Leu Gln Thr Leu Ala Pro Ala Ile Asn Trp Leu Pro Phe Leu 
                325                 330                 335     


Asn Thr Ile Phe Tyr Pro Val Glu Ile Asn Glu Ser Glu Pro Ile Val 
            340                 345                 350         


Val Tyr Asp Lys Glu Tyr Leu Glu Gln Ile Ser Thr Leu Ile Asn Thr 
        355                 360                 365             


Thr Asp Arg Cys Leu Leu Asn Asn Tyr Met Ile Trp Asn Leu Val Arg 
    370                 375                 380                 


Lys Thr Ser Ser Phe Leu Asp Gln Arg Phe Gln Asp Ala Asp Glu Lys 
385                 390                 395                 400 


Phe Met Glu Val Met Tyr Gly Thr Lys Lys Thr Cys Leu Pro Arg Trp 
                405                 410                 415     


Lys Phe Cys Val Ser Asp Thr Glu Asn Asn Leu Gly Phe Ala Leu Gly 
            420                 425                 430         


Pro Met Phe Val Lys Ala Thr Phe Ala Glu Asp Ser Lys Ser Ile Ala 
        435                 440                 445             


Thr Glu Ile Ile Leu Glu Ile Lys Lys Ala Phe Glu Glu Ser Leu Ser 
    450                 455                 460                 


Thr Leu Lys Trp Met Asp Glu Glu Thr Arg Lys Ser Ala Lys Glu Lys 
465                 470                 475                 480 


Ala Asp Ala Ile Tyr Asn Met Ile Gly Tyr Pro Asn Phe Ile Met Asp 
                485                 490                 495     


Pro Lys Glu Leu Asp Lys Val Phe Asn Asp Tyr Thr Ala Val Pro Asp 
            500                 505                 510         


Leu Tyr Phe Glu Asn Ala Met Arg Phe Phe Asn Phe Ser Trp Arg Val 
        515                 520                 525             


Thr Ala Asp Gln Leu Arg Lys Ala Pro Asn Arg Asp Gln Trp Ser Met 
    530                 535                 540                 


Thr Pro Pro Met Val Asn Ala Tyr Tyr Ser Pro Thr Lys Asn Glu Ile 
545                 550                 555                 560 


Val Phe Pro Ala Gly Ile Leu Gln Ala Pro Phe Tyr Thr Arg Ser Ser 
                565                 570                 575     


Pro Lys Ala Leu Asn Phe Gly Gly Ile Gly Val Val Val Gly His Glu 
            580                 585                 590         


Leu Thr His Ala Phe Asp Asp Gln Gly Arg Glu Tyr Asp Lys Asp Gly 
        595                 600                 605             


Asn Leu Arg Pro Trp Trp Lys Asn Ser Ser Val Glu Ala Phe Lys Arg 
    610                 615                 620                 


Gln Thr Glu Cys Met Val Glu Gln Tyr Ser Asn Tyr Ser Val Asn Gly 
625                 630                 635                 640 


Glu Pro Val Asn Gly Arg His Thr Leu Gly Glu Asn Ile Ala Asp Asn 
                645                 650                 655     


Gly Gly Leu Lys Ala Ala Tyr Arg Ala Tyr Gln Asn Trp Val Lys Lys 
            660                 665                 670         


Asn Gly Ala Glu His Ser Leu Pro Thr Leu Gly Leu Thr Asn Asn Gln 
        675                 680                 685             


Leu Phe Phe Leu Gly Phe Ala Gln Val Trp Cys Ser Val Arg Thr Pro 
    690                 695                 700                 


Glu Ser Ser His Glu Gly Leu Ile Thr Asp Pro His Ser Pro Ser Arg 
705                 710                 715                 720 


Phe Arg Val Ile Gly Ser Leu Ser Asn Ser Lys Glu Phe Ser Glu His 
                725                 730                 735     


Phe Arg Cys Pro Pro Gly Ser Pro Met Asn Pro Pro His Lys Cys Glu 
            740                 745                 750         


Val Trp 
        


<210>  1256
<211>  767
<212>  PRT
<213>  Homo sapiens

<400>  1256

Met Glu Ala Leu Arg Glu Ser Val Leu His Leu Ala Leu Gln Met Ser 
1               5                   10                  15      


Thr Tyr Lys Arg Ala Thr Leu Asp Glu Glu Asp Leu Val Asp Ser Leu 
            20                  25                  30          


Ser Glu Gly Asp Ala Tyr Pro Asn Gly Leu Gln Val Asn Phe His Ser 
        35                  40                  45              


Pro Arg Ser Gly Gln Arg Cys Trp Ala Ala Arg Thr Gln Val Glu Lys 
    50                  55                  60                  


Arg Leu Val Val Leu Val Val Leu Leu Ala Ala Gly Leu Val Ala Cys 
65                  70                  75                  80  


Leu Ala Ala Leu Gly Ile Gln Tyr Gln Thr Arg Ser Pro Ser Val Cys 
                85                  90                  95      


Leu Ser Glu Ala Cys Val Ser Val Thr Ser Ser Ile Leu Ser Ser Met 
            100                 105                 110         


Asp Pro Thr Val Asp Pro Cys His Asp Phe Phe Ser Tyr Ala Cys Gly 
        115                 120                 125             


Gly Trp Ile Lys Ala Asn Pro Val Pro Asp Gly His Ser Arg Trp Gly 
    130                 135                 140                 


Thr Phe Ser Asn Leu Trp Glu His Asn Gln Ala Ile Ile Lys His Leu 
145                 150                 155                 160 


Leu Glu Asn Ser Thr Ala Ser Val Ser Glu Ala Glu Arg Lys Ala Gln 
                165                 170                 175     


Val Tyr Tyr Arg Ala Cys Met Asn Glu Thr Arg Ile Glu Glu Leu Arg 
            180                 185                 190         


Ala Lys Pro Leu Met Glu Leu Ile Glu Arg Leu Gly Gly Trp Asn Ile 
        195                 200                 205             


Thr Gly Pro Trp Ala Lys Asp Asn Phe Gln Asp Thr Leu Gln Val Val 
    210                 215                 220                 


Thr Ala His Tyr Arg Thr Ser Pro Phe Phe Ser Val Tyr Val Ser Ala 
225                 230                 235                 240 


Asp Ser Lys Asn Ser Asn Ser Asn Val Ile Gln Val Asp Gln Ser Gly 
                245                 250                 255     


Leu Gly Leu Pro Ser Arg Asp Tyr Tyr Leu Asn Lys Thr Glu Asn Glu 
            260                 265                 270         


Lys Val Leu Thr Gly Tyr Leu Asn Tyr Met Val Gln Leu Gly Lys Leu 
        275                 280                 285             


Leu Gly Gly Gly Asp Glu Glu Ala Ile Arg Pro Gln Met Gln Gln Ile 
    290                 295                 300                 


Leu Asp Phe Glu Thr Ala Leu Ala Asn Ile Thr Ile Pro Gln Glu Lys 
305                 310                 315                 320 


Arg Arg Asp Glu Glu Leu Ile Tyr His Lys Val Thr Ala Ala Glu Leu 
                325                 330                 335     


Gln Thr Leu Ala Pro Ala Ile Asn Trp Leu Pro Phe Leu Asn Thr Ile 
            340                 345                 350         


Phe Tyr Pro Val Glu Ile Asn Glu Ser Glu Pro Ile Val Val Tyr Asp 
        355                 360                 365             


Lys Glu Tyr Leu Glu Gln Ile Ser Thr Leu Ile Asn Thr Thr Asp Arg 
    370                 375                 380                 


Cys Leu Leu Asn Asn Tyr Met Ile Trp Asn Leu Val Arg Lys Thr Ser 
385                 390                 395                 400 


Ser Phe Leu Asp Gln Arg Phe Gln Asp Ala Asp Glu Lys Phe Met Glu 
                405                 410                 415     


Val Met Tyr Gly Thr Lys Lys Thr Cys Leu Pro Arg Trp Lys Phe Cys 
            420                 425                 430         


Val Ser Asp Thr Glu Asn Asn Leu Gly Phe Ala Leu Gly Pro Met Phe 
        435                 440                 445             


Val Lys Ala Thr Phe Ala Glu Asp Ser Lys Ser Ile Ala Thr Glu Ile 
    450                 455                 460                 


Ile Leu Glu Ile Lys Lys Ala Phe Glu Glu Ser Leu Ser Thr Leu Lys 
465                 470                 475                 480 


Trp Met Asp Glu Glu Thr Arg Lys Ser Ala Lys Glu Lys Ala Asp Ala 
                485                 490                 495     


Ile Tyr Asn Met Ile Gly Tyr Pro Asn Phe Ile Met Asp Pro Lys Glu 
            500                 505                 510         


Leu Asp Lys Val Phe Asn Asp Tyr Thr Ala Val Pro Asp Leu Tyr Phe 
        515                 520                 525             


Glu Asn Ala Met Arg Phe Phe Asn Phe Ser Trp Arg Val Thr Ala Asp 
    530                 535                 540                 


Gln Leu Arg Lys Ala Pro Asn Arg Asp Gln Trp Ser Met Thr Pro Pro 
545                 550                 555                 560 


Met Val Asn Ala Tyr Tyr Ser Pro Thr Lys Asn Glu Ile Val Phe Pro 
                565                 570                 575     


Ala Gly Ile Leu Gln Ala Pro Phe Tyr Thr Arg Ser Ser Pro Lys Ala 
            580                 585                 590         


Leu Asn Phe Gly Gly Ile Gly Val Val Val Gly His Glu Leu Thr His 
        595                 600                 605             


Ala Phe Asp Asp Gln Gly Arg Glu Tyr Asp Lys Asp Gly Asn Leu Arg 
    610                 615                 620                 


Pro Trp Trp Lys Asn Ser Ser Val Glu Ala Phe Lys Arg Gln Thr Glu 
625                 630                 635                 640 


Cys Met Val Glu Gln Tyr Ser Asn Tyr Ser Val Asn Gly Glu Pro Val 
                645                 650                 655     


Asn Gly Arg His Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu 
            660                 665                 670         


Lys Ala Ala Tyr Arg Ala Tyr Gln Asn Trp Val Lys Lys Asn Gly Ala 
        675                 680                 685             


Glu His Ser Leu Pro Thr Leu Gly Leu Thr Asn Asn Gln Leu Phe Phe 
    690                 695                 700                 


Leu Gly Phe Ala Gln Val Trp Cys Ser Val Arg Thr Pro Glu Ser Ser 
705                 710                 715                 720 


His Glu Gly Leu Ile Thr Asp Pro His Ser Pro Ser Arg Phe Arg Val 
                725                 730                 735     


Ile Gly Ser Leu Ser Asn Ser Lys Glu Phe Ser Glu His Phe Arg Cys 
            740                 745                 750         


Pro Pro Gly Ser Pro Met Asn Pro Pro His Lys Cys Glu Val Trp 
        755                 760                 765         


<210>  1257
<211>  2057
<212>  PRT
<213>  Homo sapiens

<400>  1257

Met Leu Arg Leu Val Val Gln Ser Ala Lys Ile Asp Pro Pro Leu Ala 
1               5                   10                  15      


Pro Leu Pro Arg Pro Cys Met Ser Ile Asp Phe Arg Asp Ile Lys Lys 
            20                  25                  30          


Arg Thr Arg Val Val Glu Gly Asn Asp Pro Val Trp Asn Glu Thr Leu 
        35                  40                  45              


Ile Trp His Leu Trp Asn Arg Pro Leu Glu Asn Asp Ser Phe Leu Gln 
    50                  55                  60                  


Val Thr Leu Gln Asp Met Gly Ser Gln Lys Lys Glu Arg Phe Ile Gly 
65                  70                  75                  80  


Leu Ala Thr Val Leu Leu Lys Pro Leu Leu Lys Gln Pro Ser Glu Val 
                85                  90                  95      


Leu Phe Val Lys Asp Leu Thr Leu Leu Asn His Ser Met Lys Pro Thr 
            100                 105                 110         


Asp Cys Thr Val Thr Leu Gln Val Ala His Met Ser Asn Gln Asp Ile 
        115                 120                 125             


Glu Lys Thr Gly Ala Glu Asp His Leu Gly Ile Thr Ala Arg Glu Ala 
    130                 135                 140                 


Ala Ser Gln Lys Leu Met Val Pro Gly Ser Thr Ala His Arg Ala Leu 
145                 150                 155                 160 


Ser Ser Lys Pro Gln His Phe Gln Val Arg Val Lys Val Phe Glu Ala 
                165                 170                 175     


Arg Gln Leu Met Gly Asn Asn Ile Lys Pro Val Val Lys Val Ser Ile 
            180                 185                 190         


Ala Gly Gln Gln His Gln Thr Arg Ile Lys Met Gly Asn Asn Pro Phe 
        195                 200                 205             


Phe Asn Glu Ile Phe Phe Gln Asn Phe His Glu Val Pro Ala Lys Phe 
    210                 215                 220                 


Phe Asp Glu Thr Ile Leu Ile Gln Val Val Asn Ser Ser Ala Met Arg 
225                 230                 235                 240 


Tyr Lys Ala Glu Ile Gly Arg Phe Gln Thr Asp Ile Gly Phe Ile Tyr 
                245                 250                 255     


His Ser Pro Gly His Thr Leu Leu Arg Lys Trp Leu Gly Leu Cys Gln 
            260                 265                 270         


Pro Asn Asn Pro Gly Ser Gly Val Thr Gly Tyr Leu Lys Val Thr Ile 
        275                 280                 285             


Tyr Ala Leu Gly Val Gly Asp Gln Ala Leu Ile Asp Gln Lys Leu Leu 
    290                 295                 300                 


Tyr Gly Thr Asp Asp Thr Asp Ile Gln Ile Phe Lys Ser Ala Val Val 
305                 310                 315                 320 


Pro Ile Asn Met Ala Tyr Leu Gln Leu Phe Ile Tyr Cys Ala Glu Asp 
                325                 330                 335     


Leu His Leu Lys Lys His Gln Ser Val Asn Pro Gln Leu Glu Val Glu 
            340                 345                 350         


Leu Ile Gly Glu Lys Leu Arg Thr His Met Gln Thr Gln Thr Asp Asn 
        355                 360                 365             


Pro Ile Trp Asn Gln Ile Leu Thr Phe Arg Ile Gln Leu Pro Cys Leu 
    370                 375                 380                 


Ser Ser Tyr Ile Lys Phe Arg Val Leu Asp Cys Arg Lys Lys Asp Cys 
385                 390                 395                 400 


Pro Asp Glu Ile Gly Thr Ala Ser Leu Ser Leu Asn Gln Ile Ser Ser 
                405                 410                 415     


Thr Gly Glu Glu Ile Glu Gly Val Tyr Ser Gly Phe Leu Pro Cys Phe 
            420                 425                 430         


Gly Pro Ser Phe Leu Thr Leu His Gly Gly Lys Lys Ala Pro Phe Arg 
        435                 440                 445             


Ile Gln Glu Glu Gly Ala Cys Ile Pro Asp Ser Val Arg Asp Gly Leu 
    450                 455                 460                 


Ala Tyr Arg Gly Arg Val Phe Leu Glu Leu Ile Thr Gln Ile Lys Ser 
465                 470                 475                 480 


Tyr Gln Asp Ser Thr Ile Lys Asp Leu Ser His Glu Val Thr Arg Ile 
                485                 490                 495     


Glu Lys His Gln Asn Arg Gln Lys Tyr Gly Leu Cys Val Ile Phe Leu 
            500                 505                 510         


Ser Cys Thr Met Met Pro Asn Phe Lys Glu Leu Ile His Phe Glu Val 
        515                 520                 525             


Ser Ile Gly His Tyr Gly Asn Lys Met Asp Leu Asn Tyr Lys Pro Leu 
    530                 535                 540                 


Val Ser Ser Thr Pro Tyr Ser Pro Val Ile Tyr Asp Gly Asn Ile Tyr 
545                 550                 555                 560 


His Tyr Val Pro Trp Tyr Asn Thr Lys Pro Val Val Ala Val Thr Ser 
                565                 570                 575     


Asn Trp Glu Asp Val Ser Phe Arg Met Asn Cys Leu Asn Leu Leu His 
            580                 585                 590         


Phe Thr Arg Asp Arg Leu Lys Ala Asn Leu Asp Thr Leu Lys Ser Thr 
        595                 600                 605             


Arg Asn Pro Lys Asp Pro Ala Leu Leu Tyr Gln Trp Glu Lys Leu Leu 
    610                 615                 620                 


Arg Glu Leu Ala Glu Asp Cys Lys Arg Pro Leu Pro Cys Met Thr Tyr 
625                 630                 635                 640 


Gln Pro Lys Ala Thr Ser Leu Asp Arg Lys Arg Trp Gln Leu Arg Ser 
                645                 650                 655     


Leu Leu Leu Gln Glu Leu Ala Gln Lys Ala Lys Gln Ala Lys Pro Lys 
            660                 665                 670         


Asp Met Val Ala Thr Ala Glu Asp Trp Leu Tyr Arg Leu Asn Thr Val 
        675                 680                 685             


Leu Pro Glu Pro Gln Met Gly Leu Pro Asp Val Met Ile Trp Leu Val 
    690                 695                 700                 


Ala Lys Glu Gln Arg Val Ala Tyr Ala Gln Val Pro Ala His Ser Val 
705                 710                 715                 720 


Leu Phe Ser Pro Ala Gly Ala Leu His Ser Gly Arg Leu Cys Gly Lys 
                725                 730                 735     


Ile Gln Thr Leu Phe Leu Gln Tyr Pro Glu Gly Glu Gly Gln Lys Asp 
            740                 745                 750         


Val Leu Pro Ala His Leu Arg Val Cys Met Trp Leu Gly Asn Val Thr 
        755                 760                 765             


Asp Ser Lys Asp Leu Gln Leu Leu Arg Gln Gly Asp Thr Ala Val Tyr 
    770                 775                 780                 


Ala Glu Met Tyr Glu Asn Gln Ala Lys Tyr Lys Asp Gln Trp Gly Gln 
785                 790                 795                 800 


Gln Gly Leu Tyr His Cys Pro Asn Phe Ser Asp Val Met Gly Asn Lys 
                805                 810                 815     


Thr Leu Pro Met Thr Asp Phe Gln Pro Pro Leu Gly Trp His Trp Gln 
            820                 825                 830         


Asp Ser Trp Thr Val Glu Pro Gln Arg Arg Leu Leu Leu Asp Ile Asp 
        835                 840                 845             


Ile Asn Lys Ser Gln Val Leu Glu Glu Val Tyr Glu Asn Gln Gly Arg 
    850                 855                 860                 


Asp Thr Arg Gly Ala Trp Gly Pro Ala Ala Ile Pro Asn Thr Asp Val 
865                 870                 875                 880 


Asn Gly Gln Pro Met Glu Ala Arg Glu Asn Val Lys Cys Pro Gln Gly 
                885                 890                 895     


Trp His Phe Lys Lys Asp Trp Val Val Glu Leu Asn His Ala Val Asp 
            900                 905                 910         


Ser Lys Gly Trp Glu Tyr Gly Val Gly Ile Pro Pro Ser Gly Leu Pro 
        915                 920                 925             


Gln Val Trp Ser Pro Val Glu Lys Thr Tyr His Ser Cys Arg Arg Arg 
    930                 935                 940                 


Arg Trp Ala Arg Val Arg Phe Arg Asn His Gly Glu Leu Ser His Glu 
945                 950                 955                 960 


Gln Glu Thr Leu Ser Phe Leu Gln Leu Gly Leu Ala Lys Gly Glu Glu 
                965                 970                 975     


Glu Gly Trp Glu Tyr Asp Thr Phe Gly Ser Lys Phe His Leu Asn Pro 
            980                 985                 990         


Gln Pro Gln Ser Arg Phe Arg Arg  Arg Cys Trp Arg Arg  Arg Leu Ala 
        995                 1000                 1005             


Pro Asn  Lys Asp Lys Gly Ile  Ala Pro Ile Phe Leu  Leu Glu Gly 
    1010                 1015                 1020             


Ser Leu  Ala Met Asp Leu Lys  Tyr His Ala Gly Lys  Glu Glu Asp 
    1025                 1030                 1035             


Ser Lys  Thr Trp Pro Trp Gly  Leu Asp Arg Gln Phe  Arg Asp Pro 
    1040                 1045                 1050             


Gln Arg  Gln Asp Thr Arg Pro  Pro Asn Leu Pro Phe  Ile Tyr Cys 
    1055                 1060                 1065             


Thr Phe  Asn Lys Pro His Tyr  Tyr Gln Leu Phe Cys  Tyr Ile Tyr 
    1070                 1075                 1080             


Gln Ala  Arg Asn Leu Val Ser  Asn Gln Ile Leu Thr  Phe Gln Gly 
    1085                 1090                 1095             


Pro Phe  Ile Arg Val Val Phe  Leu Asn His Ser Gln  Cys Thr Gln 
    1100                 1105                 1110             


Thr Leu  Arg Ser Ser Ala Gly  Pro Thr Trp Ala Gln  Thr Leu Ile 
    1115                 1120                 1125             


Phe Gln  His Leu Leu Leu Tyr  Glu Asn Pro Gln Asp  Thr Lys Glu 
    1130                 1135                 1140             


Ser Pro  Pro Leu Val Val Leu  Glu Leu Trp Gln Arg  Asp Phe Trp 
    1145                 1150                 1155             


Gly Lys  Glu Ser Leu Trp Gly  Arg Ser Val Trp Pro  Pro Met Val 
    1160                 1165                 1170             


Trp Leu  Asp Leu Gln Asp Arg  Ile Leu Pro Pro Met  Arg Trp His 
    1175                 1180                 1185             


Pro Leu  Val Lys Glu Leu Gly  Lys Glu Glu Gly Glu  Ile Leu Ala 
    1190                 1195                 1200             


Ser Cys  Glu Leu Ile Leu Gln  Thr Glu Lys Leu Gly  Glu Lys Gln 
    1205                 1210                 1215             


Leu Pro  Ile Leu Ser Val Pro  Trp Lys Asn Gly Ala  Tyr Thr Leu 
    1220                 1225                 1230             


Pro Lys  Ser Ile Gln Pro Thr  Ile Lys Arg Met Ala  Ile Glu Ile 
    1235                 1240                 1245             


Leu Ala  Trp Gly Leu Arg Asn  Met Lys Lys Ala Ser  Ser Pro Gln 
    1250                 1255                 1260             


Leu Leu  Val Glu Phe Gly Glu  Glu Ser Leu Arg Thr  Glu Pro Ile 
    1265                 1270                 1275             


Arg Asp  Phe Gln Thr Asn Pro  Asn Phe Pro Glu Ser  Glu Ser Val 
    1280                 1285                 1290             


Leu Val  Leu Thr Val Leu Met  Pro Thr Glu Glu Ala  Tyr Ala Leu 
    1295                 1300                 1305             


Pro Leu  Val Val Lys Val Val  Asp Asn Trp Ala Phe  Gly Gln Gln 
    1310                 1315                 1320             


Thr Val  Thr Gly Gln Ala Asn  Ile Asp Phe Leu Gln  Pro Tyr Phe 
    1325                 1330                 1335             


Cys Asp  Pro Trp Ala Gln Asp  Tyr Met His Pro Lys  Leu Pro Thr 
    1340                 1345                 1350             


Leu Ser  Glu Lys Lys His Gln  Asp Phe Leu Gly Tyr  Leu Tyr Arg 
    1355                 1360                 1365             


Lys Phe  Trp Phe Lys Ser Ser  Lys Ala Glu Asp Glu  Tyr Glu His 
    1370                 1375                 1380             


Glu Val  Asp Trp Trp Ser Lys  Leu Phe Trp Ala Thr  Asp Glu His 
    1385                 1390                 1395             


Lys Ser  Leu Lys Tyr Lys Tyr  Lys Asp Tyr His Thr  Leu Lys Val 
    1400                 1405                 1410             


Tyr Glu  Cys Glu Leu Glu Ala  Val Pro Ala Phe Gln  Gly Leu Gln 
    1415                 1420                 1425             


Asp Phe  Cys Gln Thr Phe Lys  Leu Tyr Gln Glu Gln  Pro Lys Leu 
    1430                 1435                 1440             


Asp Ser  Pro Val Val Gly Glu  Phe Lys Gly Leu Phe  Arg Ile Tyr 
    1445                 1450                 1455             


Pro Phe  Pro Glu Asn Pro Glu  Ala Pro Lys Pro Pro  Leu Gln Phe 
    1460                 1465                 1470             


Leu Val  Trp Pro Glu Arg Glu  Asp Phe Pro Gln Pro  Cys Leu Val 
    1475                 1480                 1485             


Arg Val  Tyr Met Val Arg Ala  Ile Asn Leu Gln Pro  Gln Asp Tyr 
    1490                 1495                 1500             


Asn Gly  Leu Cys Asp Pro Tyr  Val Ile Leu Lys Leu  Gly Lys Thr 
    1505                 1510                 1515             


Glu Leu  Gly Asn Arg Asp Met  Tyr Gln Pro Asn Thr  Leu Asp Pro 
    1520                 1525                 1530             


Ile Phe  Gly Met Met Phe Glu  Leu Thr Cys Asn Ile  Pro Leu Glu 
    1535                 1540                 1545             


Lys Asp  Leu Glu Ile Gln Leu  Tyr Asp Phe Asp Leu  Phe Ser Pro 
    1550                 1555                 1560             


Asp Asp  Lys Ile Gly Thr Thr  Val Ile Asp Leu Glu  Asn Arg Leu 
    1565                 1570                 1575             


Leu Ser  Gly Phe Gly Ala His  Cys Gly Leu Ser Lys  Ser Tyr Cys 
    1580                 1585                 1590             


Gln Ser  Gly Pro Phe Arg Trp  Arg Asp Gln Met Pro  Pro Ser Tyr 
    1595                 1600                 1605             


Leu Leu  Glu Arg Tyr Ala Lys  Arg Lys Gly Leu Pro  Pro Pro Leu 
    1610                 1615                 1620             


Phe Ser  Pro Glu Glu Asp Ala  Val Phe Tyr Asn Gly  Lys Lys Phe 
    1625                 1630                 1635             


Lys Leu  Gln Ser Phe Glu Pro  Lys Thr Pro Thr Val  His Gly Leu 
    1640                 1645                 1650             


Gly Pro  Lys Lys Glu Arg Leu  Ala Leu Tyr Leu Leu  His Thr Gln 
    1655                 1660                 1665             


Gly Leu  Val Pro Glu His Val  Glu Thr Arg Thr Leu  Tyr Ser His 
    1670                 1675                 1680             


Ser Gln  Pro Gly Ile Asp Gln  Gly Lys Val Gln Met  Trp Val Asp 
    1685                 1690                 1695             


Ile Phe  Pro Lys Lys Leu Gly  Pro Pro Gly Pro Gln  Val Asn Ile 
    1700                 1705                 1710             


Asn Pro  Arg Lys Pro Lys Arg  Tyr Glu Leu Arg Cys  Ile Ile Trp 
    1715                 1720                 1725             


Lys Thr  Ala Asn Val Asp Leu  Val Asp Asp Asn Leu  Ser Arg Glu 
    1730                 1735                 1740             


Lys Thr  Ser Asp Ile Tyr Ile  Lys Gly Trp Leu Tyr  Gly Leu Glu 
    1745                 1750                 1755             


Lys Asp  Met Gln Lys Thr Asp  Ile His Tyr His Ser  Leu Thr Gly 
    1760                 1765                 1770             


Glu Ala  Asp Phe Asn Trp Arg  Phe Ile Phe Thr Met  Asp Tyr Leu 
    1775                 1780                 1785             


Ala Ala  Glu Arg Thr Cys Val  Gln Ser Gln Lys Asp  Tyr Ile Trp 
    1790                 1795                 1800             


Ser Leu  Asp Ala Thr Ser Met  Lys Phe Pro Ala Arg  Leu Ile Ile 
    1805                 1810                 1815             


Gln Val  Trp Asp Asn Asp Ile  Phe Ser Pro Asp Asp  Phe Leu Gly 
    1820                 1825                 1830             


Val Leu  Glu Leu Asp Leu Ser  Asp Met Pro Leu Pro  Ala Arg His 
    1835                 1840                 1845             


Ala Lys  Gln Cys Ser Ile Arg  Met Met Asp Ala Asp  Pro Lys Trp 
    1850                 1855                 1860             


Pro Tyr  Phe Ile Gln Tyr Lys  His Phe Ser Leu Phe  Lys Lys Lys 
    1865                 1870                 1875             


Thr Val  Thr Gly Trp Trp Pro  Cys Gln Val Leu Asp  Gly Gly Lys 
    1880                 1885                 1890             


Trp Arg  Leu Ser Gly Lys Val  Lys Met Ser Leu Glu  Ile Leu Ser 
    1895                 1900                 1905             


Glu Lys  Glu Ala Leu Ile Lys  Pro Ala Gly Arg Gly  Gln Ser Glu 
    1910                 1915                 1920             


Pro Asn  Gln Tyr Pro Thr Leu  His Pro Pro Leu Arg  Thr Asn Thr 
    1925                 1930                 1935             


Ser Phe  Thr Trp Leu Arg Ser  Pro Val Gln Asn Phe  Cys Tyr Ile 
    1940                 1945                 1950             


Phe Trp  Lys Arg Tyr Arg Phe  Lys Leu Ile Ala Phe  Met Val Ile 
    1955                 1960                 1965             


Ser Ile  Ile Ala Leu Met Leu  Phe Asn Phe Ile Tyr  Ser Ala Pro 
    1970                 1975                 1980             


His Tyr  Leu Ala Met Ser Trp  Ile Lys Pro Gln Leu  Gln Leu Tyr 
    1985                 1990                 1995             


Pro Pro  Ile Lys Ile Phe Asn  Ile Ile Asn Ser Leu  Asn Thr Ser 
    2000                 2005                 2010             


Asn Ala  Ser Ser Ser Ile Leu  Pro Thr Gln Asp Pro  Asn Leu Lys 
    2015                 2020                 2025             


Pro Thr  Ile Asp His Glu Trp  Lys Leu His Pro Gly  Pro Thr Asn 
    2030                 2035                 2040             


His Leu  Ser Asp Ile Phe Pro  Glu Leu Pro Ala Pro  Gly Asp 
    2045                 2050                 2055         


<210>  1258
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  1258

Met Ala Arg Arg Arg Arg Arg Ala Cys Ile Ala Leu Phe Leu Val Leu 
1               5                   10                  15      


Leu Phe Ala Phe Gly Thr Leu Met Gly Leu Arg Thr Leu Lys Ala Pro 
            20                  25                  30          


Asp Gly Leu Pro Ala Leu Gly Pro Gly Leu Glu Leu Ala Pro Phe Glu 
        35                  40                  45              


Arg Arg Pro Glu Gly Ala Pro Ala Pro Ala Ala Arg Ala Pro Ala Ala 
    50                  55                  60                  


Pro Ala Ala Pro Pro Pro Pro Pro Pro Pro Pro Arg Thr Ala Asp Pro 
65                  70                  75                  80  


Gly Gly Ser Pro Gly Pro Ala Pro Ala Glu Ala Glu Pro Ala Pro Val 
                85                  90                  95      


Gln Ser Leu Arg Val Tyr Ser Asp Leu His Ala Phe Tyr Tyr Ser Trp 
            100                 105                 110         


Tyr Gly Ser Pro Arg Arg Glu Gly His Tyr Ile His Trp Asp His Val 
        115                 120                 125             


Met Val Pro His Trp Asp Pro Lys Ile Ser Ala Ser Tyr Pro Arg Gly 
    130                 135                 140                 


Arg His Ser Pro Pro Asp Asp Leu Gly Ser Ser Phe Tyr Pro Glu Leu 
145                 150                 155                 160 


Gly Pro Tyr Ser Ser Arg Asp Pro Glu Val Leu Arg Glu His Met Thr 
                165                 170                 175     


Gln Leu Lys Glu Ala Ala Ile Gly Val Leu Val Leu Ser Trp Tyr Pro 
            180                 185                 190         


Pro Gly Met Ala Asp Asp Asn Gly Glu Pro Ser Asp Asp Leu Val Pro 
        195                 200                 205             


Ala Ile Leu Asp Thr Ala His Gln Tyr Ser Ile Gln Val Ala Phe His 
    210                 215                 220                 


Ile Gln Pro Tyr Lys Gly Arg Asp Asp Ile Thr Val His Asp Asn Ile 
225                 230                 235                 240 


Lys Tyr Ile Ile Asp Thr Tyr Gly Ser His Gly Ala Phe Tyr Arg Tyr 
                245                 250                 255     


Lys Asn Ser Met Gly Lys Ser Leu Pro Leu Phe Tyr Ile Tyr Asp Ser 
            260                 265                 270         


Tyr Leu Thr Ser Pro Glu Ala Trp Ala His Leu Leu Thr Pro Asn Gly 
        275                 280                 285             


Pro His Ser Ile Arg Asn Thr Pro Tyr Asp Gly Val Phe Ile Ala Leu 
    290                 295                 300                 


Leu Val Glu Glu Gly His Thr His Asp Ile Leu Ala Ala Gly Phe Asp 
305                 310                 315                 320 


Gly Met Tyr Thr Tyr Phe Ala Ser Asn Gly Phe Ser Phe Gly Ser Ser 
                325                 330                 335     


His Gln Asn Trp Lys Ala Val Lys Asn Phe Cys Asp Ala Asn Asn Leu 
            340                 345                 350         


Met Phe Ile Pro Ser Val Gly Pro Gly Tyr Ile Asp Thr Ser Ile Arg 
        355                 360                 365             


Pro Trp Asn Asn His Asn Thr Arg Asn Arg Val Asn Gly Lys Tyr Tyr 
    370                 375                 380                 


Glu Thr Ala Leu Gln Ala Ala Leu Thr Val Arg Pro Glu Ile Val Ser 
385                 390                 395                 400 


Ile Thr Ser Phe Asn Glu Trp His Glu Gly Thr Gln Ile Glu Lys Ala 
                405                 410                 415     


Ile Pro Lys Lys Thr Pro Thr Arg Leu Tyr Leu Asp Tyr Leu Pro His 
            420                 425                 430         


Gln Pro Ser Leu Tyr Leu Glu Leu Thr Arg Arg Trp Ala Glu His Phe 
        435                 440                 445             


Ile Lys Glu Lys Glu Gln Trp Leu Met 
    450                 455         


<210>  1259
<211>  956
<212>  PRT
<213>  Homo sapiens

<400>  1259

Met Asp Leu Leu Tyr Gly Leu Val Trp Leu Leu Thr Val Leu Leu Glu 
1               5                   10                  15      


Gly Ile Ser Gly Gln Gly Val Tyr Ala Pro Pro Thr Val Arg Ile Val 
            20                  25                  30          


His Ser Gly Leu Ala Cys Asn Ile Glu Glu Glu Arg Tyr Ser Glu Arg 
        35                  40                  45              


Val Tyr Thr Ile Arg Glu Gly Glu Thr Leu Glu Leu Thr Cys Leu Val 
    50                  55                  60                  


Thr Gly His Pro Arg Pro Gln Ile Arg Trp Thr Lys Thr Ala Gly Ser 
65                  70                  75                  80  


Ala Ser Asp Arg Phe Gln Asp Ser Ser Val Phe Asn Glu Thr Leu Arg 
                85                  90                  95      


Ile Thr Asn Ile Gln Arg His Gln Gly Gly Arg Tyr Tyr Cys Lys Ala 
            100                 105                 110         


Glu Asn Gly Leu Gly Ser Pro Ala Ile Lys Ser Ile Arg Val Asp Val 
        115                 120                 125             


Tyr Tyr Leu Asp Asp Pro Val Val Thr Val His Gln Ser Ile Gly Glu 
    130                 135                 140                 


Ala Lys Glu Gln Phe Tyr Tyr Glu Arg Thr Val Phe Leu Arg Cys Val 
145                 150                 155                 160 


Ala Asn Ser Asn Pro Pro Val Arg Tyr Ser Trp Arg Arg Gly Gln Glu 
                165                 170                 175     


Val Leu Leu Gln Gly Ser Asp Lys Gly Val Glu Ile Tyr Glu Pro Phe 
            180                 185                 190         


Phe Thr Gln Gly Glu Thr Lys Ile Leu Lys Leu Lys Asn Leu Arg Pro 
        195                 200                 205             


Gln Asp Tyr Ala Asn Tyr Ser Cys Ile Ala Ser Val Arg Asn Val Cys 
    210                 215                 220                 


Asn Ile Pro Asp Lys Met Val Ser Phe Arg Leu Ser Asn Lys Thr Ala 
225                 230                 235                 240 


Ser Pro Ser Ile Lys Leu Leu Val Asp Asp Pro Ile Val Val Asn Pro 
                245                 250                 255     


Gly Glu Ala Ile Thr Leu Val Cys Val Thr Thr Gly Gly Glu Pro Ala 
            260                 265                 270         


Pro Ser Leu Thr Trp Val Arg Ser Phe Gly Thr Leu Pro Glu Lys Thr 
        275                 280                 285             


Val Leu Asn Gly Gly Thr Leu Thr Ile Pro Ala Ile Thr Ser Asp Asp 
    290                 295                 300                 


Ala Gly Thr Tyr Ser Cys Ile Ala Asn Asn Asn Val Gly Asn Pro Ala 
305                 310                 315                 320 


Lys Lys Ser Thr Asn Ile Ile Val Arg Ala Leu Lys Lys Gly Arg Phe 
                325                 330                 335     


Trp Ile Thr Pro Asp Pro Tyr His Lys Asp Asp Asn Ile Gln Ile Gly 
            340                 345                 350         


Arg Glu Val Lys Ile Ser Cys Gln Val Glu Ala Val Pro Ser Glu Glu 
        355                 360                 365             


Leu Thr Phe Ser Trp Phe Lys Asn Gly Arg Pro Leu Arg Ser Ser Glu 
    370                 375                 380                 


Arg Met Val Ile Thr Gln Thr Asp Pro Asp Val Ser Pro Gly Thr Thr 
385                 390                 395                 400 


Asn Leu Asp Ile Ile Asp Leu Lys Phe Thr Asp Phe Gly Thr Tyr Thr 
                405                 410                 415     


Cys Val Ala Ser Leu Lys Gly Gly Gly Ile Ser Asp Ile Ser Ile Asp 
            420                 425                 430         


Val Asn Ile Ser Ser Ser Thr Val Pro Pro Asn Leu Thr Val Pro Gln 
        435                 440                 445             


Glu Lys Ser Pro Leu Val Thr Arg Glu Gly Asp Thr Ile Glu Leu Gln 
    450                 455                 460                 


Cys Gln Val Thr Gly Lys Pro Lys Pro Ile Ile Leu Trp Ser Arg Ala 
465                 470                 475                 480 


Asp Lys Glu Val Ala Met Pro Asp Gly Ser Met Gln Met Glu Ser Tyr 
                485                 490                 495     


Asp Gly Thr Leu Arg Ile Val Asn Val Ser Arg Glu Met Ser Gly Met 
            500                 505                 510         


Tyr Arg Cys Gln Thr Ser Gln Tyr Asn Gly Phe Asn Val Lys Pro Arg 
        515                 520                 525             


Glu Ala Leu Val Gln Leu Ile Val Gln Tyr Pro Pro Ala Val Glu Pro 
    530                 535                 540                 


Ala Phe Leu Glu Ile Arg Gln Gly Gln Asp Arg Ser Val Thr Met Ser 
545                 550                 555                 560 


Cys Arg Val Leu Arg Ala Tyr Pro Ile Arg Val Leu Thr Tyr Glu Trp 
                565                 570                 575     


Arg Leu Gly Asn Lys Leu Leu Arg Thr Gly Gln Phe Asp Ser Gln Glu 
            580                 585                 590         


Tyr Thr Glu Tyr Ala Val Lys Ser Leu Ser Asn Glu Asn Tyr Gly Val 
        595                 600                 605             


Tyr Asn Cys Ser Ile Ile Asn Glu Ala Gly Ala Gly Arg Cys Ser Phe 
    610                 615                 620                 


Leu Val Thr Gly Lys Ala Tyr Ala Pro Glu Phe Tyr Tyr Asp Thr Tyr 
625                 630                 635                 640 


Asn Pro Val Trp Gln Asn Arg His Arg Val Tyr Ser Tyr Ser Leu Gln 
                645                 650                 655     


Trp Thr Gln Met Asn Pro Asp Ala Val Asp Arg Ile Val Ala Tyr Arg 
            660                 665                 670         


Leu Gly Ile Arg Gln Ala Gly Gln Gln Arg Trp Trp Glu Gln Glu Ile 
        675                 680                 685             


Lys Ile Asn Gly Asn Ile Gln Lys Gly Glu Leu Ile Thr Tyr Asn Leu 
    690                 695                 700                 


Thr Glu Leu Ile Lys Pro Glu Ala Tyr Glu Val Arg Leu Thr Pro Leu 
705                 710                 715                 720 


Thr Lys Phe Gly Glu Gly Asp Ser Thr Ile Arg Val Ile Lys Tyr Ser 
                725                 730                 735     


Ala Pro Val Asn Pro His Leu Arg Glu Phe His Cys Gly Phe Glu Asp 
            740                 745                 750         


Gly Asn Ile Cys Leu Phe Thr Gln Asp Asp Thr Asp Asn Phe Asp Trp 
        755                 760                 765             


Thr Lys Gln Ser Thr Ala Thr Arg Asn Thr Lys Tyr Thr Pro Asn Thr 
    770                 775                 780                 


Gly Pro Asn Ala Asp Arg Ser Gly Ser Lys Glu Gly Phe Tyr Met Tyr 
785                 790                 795                 800 


Ile Glu Thr Ser Arg Pro Arg Leu Glu Gly Glu Lys Ala Arg Leu Leu 
                805                 810                 815     


Ser Pro Val Phe Ser Ile Ala Pro Lys Asn Pro Tyr Gly Pro Thr Asn 
            820                 825                 830         


Thr Ala Tyr Cys Phe Ser Phe Phe Tyr His Met Tyr Gly Gln His Ile 
        835                 840                 845             


Gly Val Leu Asn Val Tyr Leu Arg Leu Lys Gly Gln Thr Thr Ile Glu 
    850                 855                 860                 


Asn Pro Leu Trp Ser Ser Ser Gly Asn Lys Gly Gln Arg Trp Asn Glu 
865                 870                 875                 880 


Ala His Val Asn Ile Tyr Pro Ile Thr Ser Phe Gln Leu Ile Phe Glu 
                885                 890                 895     


Gly Ile Arg Gly Pro Gly Ile Glu Gly Asp Ile Ala Ile Asp Asp Val 
            900                 905                 910         


Ser Ile Ala Glu Gly Glu Cys Ala Lys Gln Asp Leu Ala Thr Lys Asn 
        915                 920                 925             


Ser Val Asp Gly Ala Val Gly Ile Leu Val His Ile Trp Leu Phe Pro 
    930                 935                 940                 


Ile Ile Val Leu Ile Ser Ile Leu Ser Pro Arg Arg 
945                 950                 955     


<210>  1260
<211>  1353
<212>  PRT
<213>  Homo sapiens

<400>  1260

Met Ala Ser Pro Pro His Gln Gln Leu Leu His His His Ser Thr Glu 
1               5                   10                  15      


Val Ser Cys Asp Ser Ser Gly Asp Ser Asn Ser Val Arg Val Lys Ile 
            20                  25                  30          


Asn Pro Lys Gln Leu Ser Ser Asn Ser His Pro Lys His Cys Lys Tyr 
        35                  40                  45              


Ser Ile Ser Ser Ser Cys Ser Ser Ser Gly Asp Ser Gly Gly Val Pro 
    50                  55                  60                  


Arg Arg Val Gly Gly Gly Gly Arg Leu Arg Arg Gln Lys Lys Leu Pro 
65                  70                  75                  80  


Gln Leu Phe Glu Arg Ala Ser Ser Arg Trp Trp Asp Pro Lys Phe Asp 
                85                  90                  95      


Ser Val Asn Leu Glu Glu Ala Cys Leu Glu Arg Cys Phe Pro Gln Thr 
            100                 105                 110         


Gln Arg Arg Phe Arg Tyr Ala Leu Phe Tyr Ile Gly Phe Ala Cys Leu 
        115                 120                 125             


Leu Trp Ser Ile Tyr Phe Ala Val His Met Arg Ser Arg Leu Ile Val 
    130                 135                 140                 


Met Val Ala Pro Ala Leu Cys Phe Leu Leu Val Cys Val Gly Phe Phe 
145                 150                 155                 160 


Leu Phe Thr Phe Thr Lys Leu Tyr Ala Arg His Tyr Ala Trp Thr Ser 
                165                 170                 175     


Leu Ala Leu Thr Leu Leu Val Phe Ala Leu Thr Leu Ala Ala Gln Phe 
            180                 185                 190         


Gln Val Leu Thr Pro Val Ser Gly Arg Gly Asp Ser Ser Asn Leu Thr 
        195                 200                 205             


Ala Thr Ala Arg Pro Thr Asp Thr Cys Leu Ser Gln Val Gly Ser Phe 
    210                 215                 220                 


Ser Met Cys Ile Glu Val Leu Phe Leu Leu Tyr Thr Val Met His Leu 
225                 230                 235                 240 


Pro Leu Tyr Leu Ser Leu Cys Leu Gly Val Ala Tyr Ser Val Leu Phe 
                245                 250                 255     


Glu Thr Phe Gly Tyr His Phe Arg Asp Glu Ala Cys Phe Pro Ser Pro 
            260                 265                 270         


Gly Ala Gly Ala Leu His Trp Glu Leu Leu Ser Arg Gly Leu Leu His 
        275                 280                 285             


Gly Cys Ile His Ala Ile Gly Val His Leu Phe Val Met Ser Gln Val 
    290                 295                 300                 


Arg Ser Arg Ser Thr Phe Leu Lys Val Gly Gln Ser Ile Met His Gly 
305                 310                 315                 320 


Lys Asp Leu Glu Val Glu Lys Ala Leu Lys Glu Arg Met Ile His Ser 
                325                 330                 335     


Val Met Pro Arg Ile Ile Ala Asp Asp Leu Met Lys Gln Gly Asp Glu 
            340                 345                 350         


Glu Ser Glu Asn Ser Val Lys Arg His Ala Thr Ser Ser Pro Lys Asn 
        355                 360                 365             


Arg Lys Lys Lys Ser Ser Ile Gln Lys Ala Pro Ile Ala Phe Arg Pro 
    370                 375                 380                 


Phe Lys Met Gln Gln Ile Glu Glu Val Ser Ile Leu Phe Ala Asp Ile 
385                 390                 395                 400 


Val Gly Phe Thr Lys Met Ser Ala Asn Lys Ser Ala His Ala Leu Val 
                405                 410                 415     


Gly Leu Leu Asn Asp Leu Phe Gly Arg Phe Asp Arg Leu Cys Glu Glu 
            420                 425                 430         


Thr Lys Cys Glu Lys Ile Ser Thr Leu Gly Asp Cys Tyr Tyr Cys Val 
        435                 440                 445             


Ala Gly Cys Pro Glu Pro Arg Ala Asp His Ala Tyr Cys Cys Ile Glu 
    450                 455                 460                 


Met Gly Leu Gly Met Ile Lys Ala Ile Glu Gln Phe Cys Gln Glu Lys 
465                 470                 475                 480 


Lys Glu Met Val Asn Met Arg Val Gly Val His Thr Gly Thr Val Leu 
                485                 490                 495     


Cys Gly Ile Leu Gly Met Arg Arg Phe Lys Phe Asp Val Trp Ser Asn 
            500                 505                 510         


Asp Val Asn Leu Ala Asn Leu Met Glu Gln Leu Gly Val Ala Gly Lys 
        515                 520                 525             


Val His Ile Ser Glu Ala Thr Ala Lys Tyr Leu Asp Asp Arg Tyr Glu 
    530                 535                 540                 


Met Glu Asp Gly Lys Val Ile Glu Arg Leu Gly Gln Ser Val Val Ala 
545                 550                 555                 560 


Asp Gln Leu Lys Gly Leu Lys Thr Tyr Leu Ile Ser Gly Gln Arg Ala 
                565                 570                 575     


Lys Glu Ser Arg Cys Ser Cys Ala Glu Ala Leu Leu Ser Gly Phe Glu 
            580                 585                 590         


Val Ile Asp Gly Ser Gln Val Ser Ser Gly Pro Arg Gly Gln Gly Thr 
        595                 600                 605             


Ala Ser Ser Gly Asn Val Ser Asp Leu Ala Gln Thr Val Lys Thr Phe 
    610                 615                 620                 


Asp Asn Leu Lys Thr Cys Pro Ser Cys Gly Ile Thr Phe Ala Pro Lys 
625                 630                 635                 640 


Ser Glu Ala Gly Ala Glu Gly Gly Ala Pro Gln Asn Gly Cys Gln Asp 
                645                 650                 655     


Glu His Lys Asn Ser Thr Lys Ala Ser Gly Gly Pro Asn Pro Lys Thr 
            660                 665                 670         


Gln Asn Gly Leu Leu Ser Pro Pro Gln Glu Glu Lys Leu Thr Asn Ser 
        675                 680                 685             


Gln Thr Ser Leu Cys Glu Ile Leu Gln Glu Lys Gly Arg Trp Ala Gly 
    690                 695                 700                 


Val Ser Leu Asp Gln Ser Ala Leu Leu Pro Leu Arg Phe Lys Asn Ile 
705                 710                 715                 720 


Arg Glu Lys Thr Asp Ala His Phe Val Asp Val Ile Lys Glu Asp Ser 
                725                 730                 735     


Leu Met Lys Asp Tyr Phe Phe Lys Pro Pro Ile Asn Gln Phe Ser Leu 
            740                 745                 750         


Asn Phe Leu Asp Gln Glu Leu Glu Arg Ser Tyr Arg Thr Ser Tyr Gln 
        755                 760                 765             


Glu Glu Val Ile Lys Asn Ser Pro Val Lys Thr Phe Ala Ser Pro Thr 
    770                 775                 780                 


Phe Ser Ser Leu Leu Asp Val Phe Leu Ser Thr Thr Val Phe Leu Thr 
785                 790                 795                 800 


Leu Ser Thr Thr Cys Phe Leu Lys Tyr Glu Ala Ala Thr Val Pro Pro 
                805                 810                 815     


Pro Pro Ala Ala Leu Ala Val Phe Ser Ala Ala Leu Leu Leu Glu Val 
            820                 825                 830         


Leu Ser Leu Ala Val Ser Ile Arg Met Val Phe Phe Leu Glu Asp Val 
        835                 840                 845             


Met Ala Cys Thr Lys Arg Leu Leu Glu Trp Ile Ala Gly Trp Leu Pro 
    850                 855                 860                 


Arg His Cys Ile Gly Ala Ile Leu Val Ser Leu Pro Ala Leu Ala Val 
865                 870                 875                 880 


Tyr Ser His Val Thr Ser Glu Tyr Glu Thr Asn Ile His Phe Pro Val 
                885                 890                 895     


Phe Thr Gly Ser Ala Ala Leu Ile Ala Val Val His Tyr Cys Asn Phe 
            900                 905                 910         


Cys Gln Leu Ser Ser Trp Met Arg Ser Ser Leu Ala Thr Val Val Gly 
        915                 920                 925             


Ala Gly Pro Leu Leu Leu Leu Tyr Val Ser Leu Cys Pro Asp Ser Ser 
    930                 935                 940                 


Val Leu Thr Ser Pro Leu Asp Ala Val Gln Asn Phe Ser Ser Glu Arg 
945                 950                 955                 960 


Asn Pro Cys Asn Ser Ser Val Pro Arg Asp Leu Arg Arg Pro Ala Ser 
                965                 970                 975     


Leu Ile Gly Gln Glu Val Val Leu Val Phe Phe Leu Leu Leu Leu Leu 
            980                 985                 990         


Val Trp Phe Leu Asn Arg Glu Phe  Glu Val Ser Tyr Arg  Leu His Tyr 
        995                 1000                 1005             


His Gly  Asp Val Glu Ala Asp  Leu His Arg Thr Lys  Ile Gln Ser 
    1010                 1015                 1020             


Met Arg  Asp Gln Ala Asp Trp  Leu Leu Arg Asn Ile  Ile Pro Tyr 
    1025                 1030                 1035             


His Val  Ala Glu Gln Leu Lys  Val Ser Gln Thr Tyr  Ser Lys Asn 
    1040                 1045                 1050             


His Asp  Ser Gly Gly Val Ile  Phe Ala Ser Ile Val  Asn Phe Ser 
    1055                 1060                 1065             


Glu Phe  Tyr Glu Glu Asn Tyr  Glu Gly Gly Lys Glu  Cys Tyr Arg 
    1070                 1075                 1080             


Val Leu  Asn Glu Leu Ile Gly  Asp Phe Asp Glu Leu  Leu Ser Lys 
    1085                 1090                 1095             


Pro Asp  Tyr Ser Ser Ile Glu  Lys Ile Lys Thr Ile  Gly Ala Thr 
    1100                 1105                 1110             


Tyr Met  Ala Ala Ser Gly Leu  Asn Thr Ala Gln Ala  Gln Asp Gly 
    1115                 1120                 1125             


Ser His  Pro Gln Glu His Leu  Gln Ile Leu Phe Glu  Phe Ala Lys 
    1130                 1135                 1140             


Glu Met  Met Arg Val Val Asp  Asp Phe Asn Asn Asn  Met Leu Trp 
    1145                 1150                 1155             


Phe Asn  Phe Lys Leu Arg Val  Gly Phe Asn His Gly  Pro Leu Thr 
    1160                 1165                 1170             


Ala Gly  Val Ile Gly Thr Thr  Lys Leu Leu Tyr Asp  Ile Trp Gly 
    1175                 1180                 1185             


Asp Thr  Val Asn Ile Ala Ser  Arg Met Asp Thr Thr  Gly Val Glu 
    1190                 1195                 1200             


Cys Arg  Ile Gln Val Ser Glu  Glu Ser Tyr Arg Val  Leu Ser Lys 
    1205                 1210                 1215             


Met Gly  Tyr Asp Phe Asp Tyr  Arg Gly Thr Val Asn  Val Lys Gly 
    1220                 1225                 1230             


Lys Gly  Gln Met Lys Thr Tyr  Leu Tyr Pro Lys Cys  Thr Asp His 
    1235                 1240                 1245             


Arg Val  Ile Pro Gln His Gln  Leu Ser Ile Ser Pro  Asp Ile Arg 
    1250                 1255                 1260             


Val Gln  Val Asp Gly Ser Ile  Gly Arg Ser Pro Thr  Asp Glu Ile 
    1265                 1270                 1275             


Ala Asn  Leu Val Pro Ser Val  Gln Tyr Val Asp Lys  Thr Ser Leu 
    1280                 1285                 1290             


Gly Ser  Asp Ser Ser Thr Gln  Ala Lys Asp Ala His  Leu Ser Pro 
    1295                 1300                 1305             


Lys Arg  Pro Trp Lys Glu Pro  Val Lys Ala Glu Glu  Arg Gly Arg 
    1310                 1315                 1320             


Phe Gly  Lys Ala Ile Glu Lys  Asp Asp Cys Asp Glu  Thr Gly Ile 
    1325                 1330                 1335             


Glu Glu  Ala Asn Glu Leu Thr  Lys Leu Asn Val Ser  Lys Ser Val 
    1340                 1345                 1350             


<210>  1261
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  1261

Met Val Trp Lys Trp Met Pro Leu Leu Leu Leu Leu Val Cys Val Ala 
1               5                   10                  15      


Thr Met Cys Ser Ala Gln Asp Arg Thr Asp Leu Leu Asn Val Cys Met 
            20                  25                  30          


Asp Ala Lys His His Lys Thr Lys Pro Gly Pro Glu Asp Lys Leu His 
        35                  40                  45              


Asp Gln Cys Ser Pro Trp Lys Lys Asn Ala Cys Cys Thr Ala Ser Thr 
    50                  55                  60                  


Ser Gln Glu Leu His Lys Asp Thr Ser Arg Leu Tyr Asn Phe Asn Trp 
65                  70                  75                  80  


Asp His Cys Gly Lys Met Glu Pro Ala Cys Lys Arg His Phe Ile Gln 
                85                  90                  95      


Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn Leu Gly Pro Trp Ile Gln 
            100                 105                 110         


Gln Val Asn Gln Ser Trp Arg Lys Glu Arg Phe Leu Asp Val Pro Leu 
        115                 120                 125             


Cys Lys Glu Asp Cys Gln Arg Trp Trp Glu Asp Cys His Thr Ser His 
    130                 135                 140                 


Thr Cys Lys Ser Asn Trp His Arg Gly Trp Asp Trp Thr Ser Gly Val 
145                 150                 155                 160 


Asn Lys Cys Pro Ala Gly Ala Leu Cys Arg Thr Phe Glu Ser Tyr Phe 
                165                 170                 175     


Pro Thr Pro Ala Ala Leu Cys Glu Gly Leu Trp Ser His Ser Tyr Lys 
            180                 185                 190         


Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg Cys Ile Gln Met Trp Phe 
        195                 200                 205             


Asp Ser Ala Gln Gly Asn Pro Asn Glu Glu Val Ala Arg Phe Tyr Ala 
    210                 215                 220                 


Ala Ala Met His Val Asn Ala Gly Glu Met Leu His Gly Thr Gly Gly 
225                 230                 235                 240 


Leu Leu Leu Ser Leu Ala Leu Met Leu Gln Leu Trp Leu Leu Gly 
                245                 250                 255 


<210>  1262
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  1262

Met Val Trp Lys Trp Met Pro Leu Leu Leu Leu Leu Val Cys Val Ala 
1               5                   10                  15      


Thr Met Cys Ser Ala Gln Asp Arg Thr Asp Leu Leu Asn Val Cys Met 
            20                  25                  30          


Asp Ala Lys His His Lys Thr Lys Pro Gly Pro Glu Asp Lys Leu His 
        35                  40                  45              


Asp Gln Cys Ser Pro Trp Lys Lys Asn Ala Cys Cys Thr Ala Ser Thr 
    50                  55                  60                  


Ser Gln Glu Leu His Lys Asp Thr Ser Arg Leu Tyr Asn Phe Asn Trp 
65                  70                  75                  80  


Asp His Cys Gly Lys Met Glu Pro Ala Cys Lys Arg His Phe Ile Gln 
                85                  90                  95      


Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn Leu Gly Pro Trp Ile Gln 
            100                 105                 110         


Gln Val Asn Gln Ser Trp Arg Lys Glu Arg Phe Leu Asp Val Pro Leu 
        115                 120                 125             


Cys Lys Glu Asp Cys Gln Arg Trp Trp Glu Asp Cys His Thr Ser His 
    130                 135                 140                 


Thr Cys Lys Ser Asn Trp His Arg Gly Trp Asp Trp Thr Ser Gly Val 
145                 150                 155                 160 


Asn Lys Cys Pro Ala Gly Ala Leu Cys Arg Thr Phe Glu Ser Tyr Phe 
                165                 170                 175     


Pro Thr Pro Ala Ala Leu Cys Glu Gly Leu Trp Ser His Ser Tyr Lys 
            180                 185                 190         


Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg Cys Ile Gln Met Trp Phe 
        195                 200                 205             


Asp Ser Ala Gln Gly Asn Pro Asn Glu Glu Val Ala Arg Phe Tyr Ala 
    210                 215                 220                 


Ala Ala Met His Val Asn Ala Gly Glu Met Leu His Gly Thr Gly Gly 
225                 230                 235                 240 


Leu Leu Leu Ser Leu Ala Leu Met Leu Gln Leu Trp Leu Leu Gly 
                245                 250                 255 


<210>  1263
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  1263

Met Val Trp Lys Trp Met Pro Leu Leu Leu Leu Leu Val Cys Val Ala 
1               5                   10                  15      


Thr Met Cys Ser Ala Gln Asp Arg Thr Asp Leu Leu Asn Val Cys Met 
            20                  25                  30          


Asp Ala Lys His His Lys Thr Lys Pro Gly Pro Glu Asp Lys Leu His 
        35                  40                  45              


Asp Gln Cys Ser Pro Trp Lys Lys Asn Ala Cys Cys Thr Ala Ser Thr 
    50                  55                  60                  


Ser Gln Glu Leu His Lys Asp Thr Ser Arg Leu Tyr Asn Phe Asn Trp 
65                  70                  75                  80  


Asp His Cys Gly Lys Met Glu Pro Ala Cys Lys Arg His Phe Ile Gln 
                85                  90                  95      


Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn Leu Gly Pro Trp Ile Gln 
            100                 105                 110         


Gln Val Asn Gln Ser Trp Arg Lys Glu Arg Phe Leu Asp Val Pro Leu 
        115                 120                 125             


Cys Lys Glu Asp Cys Gln Arg Trp Trp Glu Asp Cys His Thr Ser His 
    130                 135                 140                 


Thr Cys Lys Ser Asn Trp His Arg Gly Trp Asp Trp Thr Ser Gly Val 
145                 150                 155                 160 


Asn Lys Cys Pro Ala Gly Ala Leu Cys Arg Thr Phe Glu Ser Tyr Phe 
                165                 170                 175     


Pro Thr Pro Ala Ala Leu Cys Glu Gly Leu Trp Ser His Ser Tyr Lys 
            180                 185                 190         


Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg Cys Ile Gln Met Trp Phe 
        195                 200                 205             


Asp Ser Ala Gln Gly Asn Pro Asn Glu Glu Val Ala Arg Phe Tyr Ala 
    210                 215                 220                 


Ala Ala Met His Val Asn Ala Gly Glu Met Leu His Gly Thr Gly Gly 
225                 230                 235                 240 


Leu Leu Leu Ser Leu Ala Leu Met Leu Gln Leu Trp Leu Leu Gly 
                245                 250                 255 


<210>  1264
<211>  592
<212>  PRT
<213>  Homo sapiens

<400>  1264

Met Lys Arg Ser Lys Glu Leu Ile Thr Lys Asn His Ser Gln Glu Glu 
1               5                   10                  15      


Thr Ser Ile Leu Arg Cys Trp Lys Cys Arg Lys Cys Ile Ala Ser Ser 
            20                  25                  30          


Gly Cys Phe Met Glu Tyr Leu Glu Asn Gln Val Ile Lys Asp Lys Asp 
        35                  40                  45              


Asp Ser Val Asp Ala Gln Asn Ile Cys His Val Trp His Met Asn Val 
    50                  55                  60                  


Glu Ala Leu Pro Glu Trp Ile Ser Cys Leu Ile Gln Lys Ala Gln Trp 
65                  70                  75                  80  


Thr Val Gly Lys Leu Asn Cys Pro Phe Cys Gly Ala Arg Leu Gly Gly 
                85                  90                  95      


Phe Asn Phe Val Ser Thr Pro Lys Cys Ser Cys Gly Gln Leu Ala Ala 
            100                 105                 110         


Val His Leu Ser Lys Ser Arg Thr Asp Tyr Gln Pro Thr Gln Ala Gly 
        115                 120                 125             


Arg Leu Met Arg Pro Ser Val Lys Tyr Leu Ser His Pro Arg Val Gln 
    130                 135                 140                 


Ser Gly Cys Asp Lys Glu Ala Leu Leu Thr Gly Gly Gly Ser Glu Asn 
145                 150                 155                 160 


Arg Asn His Arg Leu Leu Asn Met Ala Arg Asn Asn Asn Asp Pro Gly 
                165                 170                 175     


Arg Leu Thr Glu Ala Leu Cys Leu Glu Val Arg Pro Thr Tyr Phe Glu 
            180                 185                 190         


Met Lys Asn Glu Lys Leu Leu Ser Lys Ala Ser Glu Pro Lys Tyr Gln 
        195                 200                 205             


Leu Phe Val Pro Gln Leu Val Thr Gly Arg Cys Ala Thr Arg Ala Phe 
    210                 215                 220                 


His Arg Lys Ser His Ser Leu Asp Leu Asn Ile Ser Glu Lys Leu Thr 
225                 230                 235                 240 


Leu Leu Pro Thr Leu Tyr Glu Ile His Ser Lys Thr Thr Ala Tyr Ser 
                245                 250                 255     


Arg Leu Asn Glu Thr Gln Pro Ile Asp Leu Ser Gly Leu Pro Leu Gln 
            260                 265                 270         


Ser Ser Lys Asn Ser Tyr Ser Phe Gln Asn Pro Ser Ser Phe Asp Pro 
        275                 280                 285             


Ser Met Leu Leu Gln Arg Phe Ser Val Ala Pro His Glu Thr Gln Thr 
    290                 295                 300                 


Gln Arg Gly Gly Glu Phe Gln Cys Gly Leu Glu Ala Ala Ser Val Tyr 
305                 310                 315                 320 


Ser Asp His Thr Asn Thr Asn Asn Leu Thr Phe Leu Met Asp Leu Pro 
                325                 330                 335     


Ser Ala Gly Arg Ser Met Pro Glu Ala Ser Asp Gln Glu Glu His Leu 
            340                 345                 350         


Ser Pro Leu Asp Phe Leu His Ser Ala Asn Phe Ser Leu Gly Ser Ile 
        355                 360                 365             


Asn Gln Arg Leu Asn Lys Arg Glu Arg Ser Lys Leu Lys Asn Leu Arg 
    370                 375                 380                 


Arg Lys Gln Arg Arg Arg Glu Arg Trp Leu Gln Lys Gln Gly Lys Tyr 
385                 390                 395                 400 


Ser Gly Val Gly Leu Leu Asp His Met Thr Leu Asn Asn Glu Met Ser 
                405                 410                 415     


Thr Asp Glu Asp Asn Glu Tyr Ala Glu Glu Lys Asp Ser Tyr Ile Cys 
            420                 425                 430         


Ala Val Cys Leu Asp Val Tyr Phe Asn Pro Tyr Met Cys Tyr Pro Cys 
        435                 440                 445             


His His Ile Phe Cys Glu Pro Cys Leu Arg Thr Leu Ala Lys Asp Asn 
    450                 455                 460                 


Pro Ser Ser Thr Pro Cys Pro Leu Cys Arg Thr Ile Ile Ser Arg Val 
465                 470                 475                 480 


Phe Phe Gln Thr Glu Leu Asn Asn Ala Thr Lys Thr Phe Phe Thr Lys 
                485                 490                 495     


Glu Tyr Leu Lys Ile Lys Gln Ser Phe Gln Lys Ser Asn Ser Ala Lys 
            500                 505                 510         


Trp Pro Leu Pro Ser Cys Arg Lys Ala Phe His Leu Phe Gly Gly Phe 
        515                 520                 525             


Arg Arg His Ala Ala Pro Val Thr Arg Arg Gln Phe Pro His Gly Ala 
    530                 535                 540                 


His Arg Met Asp Tyr Leu His Phe Glu Asp Asp Ser Arg Gly Trp Trp 
545                 550                 555                 560 


Phe Asp Met Asp Met Val Ile Ile Tyr Ile Tyr Ser Val Asn Trp Val 
                565                 570                 575     


Ile Gly Phe Ile Val Phe Cys Phe Leu Cys Tyr Phe Phe Phe Pro Phe 
            580                 585                 590         


<210>  1265
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  1265

Met Gln Pro Gln His Gly Pro Trp Gln Thr Arg Met Arg Lys Ile Ser 
1               5                   10                  15      


Asn His Gly Ser Leu Arg Val Ala Lys Val Ala Tyr Pro Leu Gly Leu 
            20                  25                  30          


Cys Val Gly Val Phe Ile Tyr Val Ala Tyr Ile Lys Trp His Arg Ala 
        35                  40                  45              


Thr Ala Thr Gln Ala Phe Phe Ser Ile Thr Arg Ala Ala Pro Gly Ala 
    50                  55                  60                  


Arg Trp Gly Gln Gln Ala His Ser Pro Leu Gly Thr Ala Ala Asp Gly 
65                  70                  75                  80  


His Glu Val Phe Tyr Gly Ile Met Phe Asp Ala Gly Ser Thr Gly Thr 
                85                  90                  95      


Arg Val His Val Phe Gln Phe Thr Arg Pro Pro Arg Glu Thr Pro Thr 
            100                 105                 110         


Leu Thr His Glu Thr Phe Lys Ala Leu Lys Pro Gly Leu Ser Ala Tyr 
        115                 120                 125             


Ala Asp Asp Val Glu Lys Ser Ala Gln Gly Ile Arg Glu Leu Leu Asp 
    130                 135                 140                 


Val Ala Lys Gln Asp Ile Pro Phe Asp Phe Trp Lys Ala Thr Pro Leu 
145                 150                 155                 160 


Val Leu Lys Ala Thr Ala Gly Leu Arg Leu Leu Pro Gly Glu Lys Ala 
                165                 170                 175     


Gln Lys Leu Leu Gln Lys Val Lys Glu Val Phe Lys Ala Ser Pro Phe 
            180                 185                 190         


Leu Val Gly Asp Asp Cys Val Ser Ile Met Asn Gly Thr Asp Glu Gly 
        195                 200                 205             


Val Ser Ala Trp Ile Thr Ile Asn Phe Leu Thr Gly Ser Leu Lys Thr 
    210                 215                 220                 


Pro Gly Gly Ser Ser Val Gly Met Leu Asp Leu Gly Gly Gly Ser Thr 
225                 230                 235                 240 


Gln Ile Ala Phe Leu Pro Arg Val Glu Gly Thr Leu Gln Ala Ser Pro 
                245                 250                 255     


Pro Gly Tyr Leu Thr Ala Leu Arg Met Phe Asn Arg Thr Tyr Lys Leu 
            260                 265                 270         


Tyr Ser Tyr Ser Tyr Leu Gly Leu Gly Leu Met Ser Ala Arg Leu Ala 
        275                 280                 285             


Ile Leu Gly Gly Val Glu Gly Gln Pro Ala Lys Asp Gly Lys Glu Leu 
    290                 295                 300                 


Val Ser Pro Cys Leu Ser Pro Ser Phe Lys Gly Glu Trp Glu His Ala 
305                 310                 315                 320 


Glu Val Thr Tyr Arg Val Ser Gly Gln Lys Ala Ala Ala Ser Leu His 
                325                 330                 335     


Glu Leu Cys Ala Ala Arg Val Ser Glu Val Leu Gln Asn Arg Val His 
            340                 345                 350         


Arg Thr Glu Glu Val Lys His Val Asp Phe Tyr Ala Phe Ser Tyr Tyr 
        355                 360                 365             


Tyr Asp Leu Ala Ala Gly Val Gly Leu Ile Asp Ala Glu Lys Gly Gly 
    370                 375                 380                 


Ser Leu Val Val Gly Asp Phe Glu Ile Ala Ala Lys Tyr Val Cys Arg 
385                 390                 395                 400 


Thr Leu Glu Thr Gln Pro Gln Ser Ser Pro Phe Ser Cys Met Asp Leu 
                405                 410                 415     


Thr Tyr Val Ser Leu Leu Leu Gln Glu Phe Gly Phe Pro Arg Ser Lys 
            420                 425                 430         


Val Leu Lys Leu Thr Arg Lys Ile Asp Asn Val Glu Thr Ser Trp Ala 
        435                 440                 445             


Leu Gly Ala Ile Phe His Tyr Ile Asp Ser Leu Asn Arg Gln Lys Ser 
    450                 455                 460                 


Pro Ala Ser 
465         


<210>  1266
<211>  840
<212>  PRT
<213>  Homo sapiens

<400>  1266

Met Gly Thr Pro Arg Ala Gln His Pro Pro Pro Pro Gln Leu Leu Phe 
1               5                   10                  15      


Leu Ile Leu Leu Ser Cys Pro Trp Ile Gln Gly Leu Pro Leu Lys Glu 
            20                  25                  30          


Glu Glu Ile Leu Pro Glu Pro Gly Ser Glu Thr Pro Thr Val Ala Ser 
        35                  40                  45              


Glu Ala Leu Ala Glu Leu Leu His Gly Ala Leu Leu Arg Arg Gly Pro 
    50                  55                  60                  


Glu Met Gly Tyr Leu Pro Gly Pro Pro Leu Gly Pro Glu Gly Gly Glu 
65                  70                  75                  80  


Glu Glu Thr Thr Thr Thr Ile Ile Thr Thr Thr Thr Val Thr Thr Thr 
                85                  90                  95      


Val Thr Ser Pro Val Leu Cys Asn Asn Asn Ile Ser Glu Gly Glu Gly 
            100                 105                 110         


Tyr Val Glu Ser Pro Asp Leu Gly Ser Pro Val Ser Arg Thr Leu Gly 
        115                 120                 125             


Leu Leu Asp Cys Thr Tyr Ser Ile His Val Tyr Pro Gly Tyr Gly Ile 
    130                 135                 140                 


Glu Ile Gln Val Gln Thr Leu Asn Leu Ser Gln Glu Glu Glu Leu Leu 
145                 150                 155                 160 


Val Leu Ala Gly Gly Gly Ser Pro Gly Leu Ala Pro Arg Leu Leu Ala 
                165                 170                 175     


Asn Ser Ser Met Leu Gly Glu Gly Gln Val Leu Arg Ser Pro Thr Asn 
            180                 185                 190         


Arg Leu Leu Leu His Phe Gln Ser Pro Arg Val Pro Arg Gly Gly Gly 
        195                 200                 205             


Phe Arg Ile His Tyr Gln Ala Tyr Leu Leu Ser Cys Gly Phe Pro Pro 
    210                 215                 220                 


Arg Pro Ala His Gly Asp Val Ser Val Thr Asp Leu His Pro Gly Gly 
225                 230                 235                 240 


Thr Ala Thr Phe His Cys Asp Ser Gly Tyr Gln Leu Gln Gly Glu Glu 
                245                 250                 255     


Thr Leu Ile Cys Leu Asn Gly Thr Arg Pro Ser Trp Asn Gly Glu Thr 
            260                 265                 270         


Pro Ser Cys Met Ala Ser Cys Gly Gly Thr Ile His Asn Ala Thr Leu 
        275                 280                 285             


Gly Arg Ile Val Ser Pro Glu Pro Gly Gly Ala Val Gly Pro Asn Leu 
    290                 295                 300                 


Thr Cys Arg Trp Val Ile Glu Ala Ala Glu Gly Arg Arg Leu His Leu 
305                 310                 315                 320 


His Phe Glu Arg Val Ser Leu Asp Glu Asp Asn Asp Arg Leu Met Val 
                325                 330                 335     


Arg Ser Gly Gly Ser Pro Leu Ser Pro Val Ile Tyr Asp Ser Asp Met 
            340                 345                 350         


Asp Asp Val Pro Glu Arg Gly Leu Ile Ser Asp Ala Gln Ser Leu Tyr 
        355                 360                 365             


Val Glu Leu Leu Ser Glu Thr Pro Ala Asn Pro Leu Leu Leu Ser Leu 
    370                 375                 380                 


Arg Phe Glu Ala Phe Glu Glu Asp Arg Cys Phe Ala Pro Phe Leu Ala 
385                 390                 395                 400 


His Gly Asn Val Thr Thr Thr Asp Pro Glu Tyr Arg Pro Gly Ala Leu 
                405                 410                 415     


Ala Thr Phe Ser Cys Leu Pro Gly Tyr Ala Leu Glu Pro Pro Gly Pro 
            420                 425                 430         


Pro Asn Ala Ile Glu Cys Val Asp Pro Thr Glu Pro His Trp Asn Asp 
        435                 440                 445             


Thr Glu Pro Ala Cys Lys Ala Met Cys Gly Gly Glu Leu Ser Glu Pro 
    450                 455                 460                 


Ala Gly Val Val Leu Ser Pro Asp Trp Pro Gln Ser Tyr Ser Pro Gly 
465                 470                 475                 480 


Gln Asp Cys Val Trp Gly Val His Val Gln Glu Glu Lys Arg Ile Leu 
                485                 490                 495     


Leu Gln Val Glu Ile Leu Asn Val Arg Glu Gly Asp Met Leu Thr Leu 
            500                 505                 510         


Phe Asp Gly Asp Gly Pro Ser Ala Arg Val Leu Ala Gln Leu Arg Gly 
        515                 520                 525             


Pro Gln Pro Arg Arg Arg Leu Leu Ser Ser Gly Pro Asp Leu Thr Leu 
    530                 535                 540                 


Gln Phe Gln Ala Pro Pro Gly Pro Pro Asn Pro Gly Leu Gly Gln Gly 
545                 550                 555                 560 


Phe Val Leu His Phe Lys Glu Val Pro Arg Asn Asp Thr Cys Pro Glu 
                565                 570                 575     


Leu Pro Pro Pro Glu Trp Gly Trp Arg Thr Ala Ser His Gly Asp Leu 
            580                 585                 590         


Ile Arg Gly Thr Val Leu Thr Tyr Gln Cys Glu Pro Gly Tyr Glu Leu 
        595                 600                 605             


Leu Gly Ser Asp Ile Leu Thr Cys Gln Trp Asp Leu Ser Trp Ser Ala 
    610                 615                 620                 


Ala Pro Pro Ala Cys Gln Lys Ile Met Thr Cys Ala Asp Pro Gly Glu 
625                 630                 635                 640 


Ile Ala Asn Gly His Arg Thr Ala Ser Asp Ala Gly Phe Pro Val Gly 
                645                 650                 655     


Ser His Val Gln Tyr Arg Cys Leu Pro Gly Tyr Ser Leu Glu Gly Ala 
            660                 665                 670         


Ala Met Leu Thr Cys Tyr Ser Arg Asp Thr Gly Thr Pro Lys Trp Ser 
        675                 680                 685             


Asp Arg Val Pro Lys Cys Ala Leu Lys Tyr Glu Pro Cys Leu Asn Pro 
    690                 695                 700                 


Gly Val Pro Glu Asn Gly Tyr Gln Thr Leu Tyr Lys His His Tyr Gln 
705                 710                 715                 720 


Ala Gly Glu Ser Leu Arg Phe Phe Cys Tyr Glu Gly Phe Glu Leu Ile 
                725                 730                 735     


Gly Glu Val Thr Ile Thr Cys Val Pro Gly His Pro Ser Gln Trp Thr 
            740                 745                 750         


Ser Gln Pro Pro Leu Cys Lys Val Thr Gln Thr Thr Asp Pro Ser Arg 
        755                 760                 765             


Gln Leu Glu Gly Gly Asn Leu Ala Leu Ala Ile Leu Leu Pro Leu Gly 
    770                 775                 780                 


Leu Val Ile Val Leu Gly Ser Gly Val Tyr Ile Tyr Tyr Thr Lys Leu 
785                 790                 795                 800 


Gln Gly Lys Ser Leu Phe Gly Phe Ser Gly Ser His Ser Tyr Ser Pro 
                805                 810                 815     


Ile Thr Val Glu Ser Asp Phe Ser Asn Pro Leu Tyr Glu Ala Gly Asp 
            820                 825                 830         


Thr Arg Glu Tyr Glu Val Ser Ile 
        835                 840 


<210>  1267
<211>  809
<212>  PRT
<213>  Homo sapiens

<400>  1267

Met Gly Thr Pro Arg Ala Gln His Pro Pro Pro Pro Gln Leu Leu Phe 
1               5                   10                  15      


Leu Ile Leu Leu Ser Cys Pro Trp Ile Gln Gly Leu Pro Leu Lys Glu 
            20                  25                  30          


Glu Glu Ile Leu Pro Glu Pro Gly Ser Glu Thr Pro Thr Val Ala Ser 
        35                  40                  45              


Glu Ala Leu Ala Glu Leu Leu His Gly Ala Leu Leu Arg Arg Gly Pro 
    50                  55                  60                  


Glu Met Gly Tyr Leu Pro Gly Ser Asp Arg Asp Pro Thr Leu Ala Thr 
65                  70                  75                  80  


Pro Pro Ala Gly Gln Thr Leu Ala Val Pro Ser Leu Pro Arg Ala Thr 
                85                  90                  95      


Glu Pro Gly Thr Gly Pro Leu Thr Thr Ala Val Thr Pro Asn Gly Val 
            100                 105                 110         


Arg Gly Ala Gly Pro Thr Ala Pro Glu Leu Leu Thr Pro Pro Pro Gly 
        115                 120                 125             


Thr Thr Ala Pro Pro Pro Pro Ser Pro Ala Ser Pro Gly Pro Pro Leu 
    130                 135                 140                 


Gly Pro Glu Gly Gly Glu Glu Glu Thr Thr Thr Thr Ile Ile Thr Thr 
145                 150                 155                 160 


Thr Thr Val Thr Thr Thr Val Thr Ser Pro Ala Tyr Leu Leu Ser Cys 
                165                 170                 175     


Gly Phe Pro Pro Arg Pro Ala His Gly Asp Val Ser Val Thr Asp Leu 
            180                 185                 190         


His Pro Gly Gly Thr Ala Thr Phe His Cys Asp Ser Gly Tyr Gln Leu 
        195                 200                 205             


Gln Gly Glu Glu Thr Leu Ile Cys Leu Asn Gly Thr Arg Pro Ser Trp 
    210                 215                 220                 


Asn Gly Glu Thr Pro Ser Cys Met Ala Ser Cys Gly Gly Thr Ile His 
225                 230                 235                 240 


Asn Ala Thr Leu Gly Arg Ile Val Ser Pro Glu Pro Gly Gly Ala Val 
                245                 250                 255     


Gly Pro Asn Leu Thr Cys Arg Trp Val Ile Glu Ala Ala Glu Gly Arg 
            260                 265                 270         


Arg Leu His Leu His Phe Glu Arg Val Ser Leu Asp Glu Asp Asn Asp 
        275                 280                 285             


Arg Leu Met Val Arg Ser Gly Gly Ser Pro Leu Ser Pro Val Ile Tyr 
    290                 295                 300                 


Asp Ser Asp Met Asp Asp Val Pro Glu Arg Gly Leu Ile Ser Asp Ala 
305                 310                 315                 320 


Gln Ser Leu Tyr Val Glu Leu Leu Ser Glu Thr Pro Ala Asn Pro Leu 
                325                 330                 335     


Leu Leu Ser Leu Arg Phe Glu Ala Phe Glu Glu Asp Arg Cys Phe Ala 
            340                 345                 350         


Pro Phe Leu Ala His Gly Asn Val Thr Thr Thr Asp Pro Glu Tyr Arg 
        355                 360                 365             


Pro Gly Ala Leu Ala Thr Phe Ser Cys Leu Pro Gly Tyr Ala Leu Glu 
    370                 375                 380                 


Pro Pro Gly Pro Pro Asn Ala Ile Glu Cys Val Asp Pro Thr Glu Pro 
385                 390                 395                 400 


His Trp Asn Asp Thr Glu Pro Ala Cys Lys Ala Met Cys Gly Gly Glu 
                405                 410                 415     


Leu Ser Glu Pro Ala Gly Val Val Leu Ser Pro Asp Trp Pro Gln Ser 
            420                 425                 430         


Tyr Ser Pro Gly Gln Asp Cys Val Trp Gly Val His Val Gln Glu Glu 
        435                 440                 445             


Lys Arg Ile Leu Leu Gln Val Glu Ile Leu Asn Val Arg Glu Gly Asp 
    450                 455                 460                 


Met Leu Thr Leu Phe Asp Gly Asp Gly Pro Ser Ala Arg Val Leu Ala 
465                 470                 475                 480 


Gln Leu Arg Gly Pro Gln Pro Arg Arg Arg Leu Leu Ser Ser Gly Pro 
                485                 490                 495     


Asp Leu Thr Leu Gln Phe Gln Ala Pro Pro Gly Pro Pro Asn Pro Gly 
            500                 505                 510         


Leu Gly Gln Gly Phe Val Leu His Phe Lys Glu Val Pro Arg Asn Asp 
        515                 520                 525             


Thr Cys Pro Glu Leu Pro Pro Pro Glu Trp Gly Trp Arg Thr Ala Ser 
    530                 535                 540                 


His Gly Asp Leu Ile Arg Gly Thr Val Leu Thr Tyr Gln Cys Glu Pro 
545                 550                 555                 560 


Gly Tyr Glu Leu Leu Gly Ser Asp Ile Leu Thr Cys Gln Trp Asp Leu 
                565                 570                 575     


Ser Trp Ser Ala Ala Pro Pro Ala Cys Gln Lys Ile Met Thr Cys Ala 
            580                 585                 590         


Asp Pro Gly Glu Ile Ala Asn Gly His Arg Thr Ala Ser Asp Ala Gly 
        595                 600                 605             


Phe Pro Val Gly Ser His Val Gln Tyr Arg Cys Leu Pro Gly Tyr Ser 
    610                 615                 620                 


Leu Glu Gly Ala Ala Met Leu Thr Cys Tyr Ser Arg Asp Thr Gly Thr 
625                 630                 635                 640 


Pro Lys Trp Ser Asp Arg Val Pro Lys Cys Ala Leu Lys Tyr Glu Pro 
                645                 650                 655     


Cys Leu Asn Pro Gly Val Pro Glu Asn Gly Tyr Gln Thr Leu Tyr Lys 
            660                 665                 670         


His His Tyr Gln Ala Gly Glu Ser Leu Arg Phe Phe Cys Tyr Glu Gly 
        675                 680                 685             


Phe Glu Leu Ile Gly Glu Val Thr Ile Thr Cys Val Pro Gly His Pro 
    690                 695                 700                 


Ser Gln Trp Thr Ser Gln Pro Pro Leu Cys Lys Val Ala Tyr Glu Glu 
705                 710                 715                 720 


Leu Leu Asp Asn Arg Lys Leu Glu Val Thr Gln Thr Thr Asp Pro Ser 
                725                 730                 735     


Arg Gln Leu Glu Gly Gly Asn Leu Ala Leu Ala Ile Leu Leu Pro Leu 
            740                 745                 750         


Gly Leu Val Ile Val Leu Gly Ser Gly Val Tyr Ile Tyr Tyr Thr Lys 
        755                 760                 765             


Leu Gln Gly Lys Ser Leu Phe Gly Phe Ser Gly Ser His Ser Tyr Ser 
    770                 775                 780                 


Pro Ile Thr Val Glu Ser Asp Phe Ser Asn Pro Leu Tyr Glu Ala Gly 
785                 790                 795                 800 


Asp Thr Arg Glu Tyr Glu Val Ser Ile 
                805                 


<210>  1268
<211>  653
<212>  PRT
<213>  Homo sapiens

<400>  1268

Met His Cys Leu Gly Ala Glu Tyr Leu Val Ser Ala Glu Gly Ala Pro 
1               5                   10                  15      


Arg Gln Arg Glu Trp Arg Pro Gln Ile Tyr Arg Lys Cys Thr Asp Thr 
            20                  25                  30          


Ala Trp Leu Phe Leu Phe Phe Leu Phe Trp Thr Gly Leu Val Phe Ile 
        35                  40                  45              


Met Gly Tyr Ser Val Val Ala Gly Ala Ala Gly Arg Leu Leu Phe Gly 
    50                  55                  60                  


Tyr Asp Ser Phe Gly Asn Met Cys Gly Lys Lys Asn Ser Pro Val Glu 
65                  70                  75                  80  


Gly Ala Pro Leu Ser Gly Gln Asp Met Thr Leu Lys Lys His Val Phe 
                85                  90                  95      


Phe Met Asn Ser Cys Asn Leu Glu Val Lys Gly Thr Gln Leu Asn Arg 
            100                 105                 110         


Met Ala Leu Cys Val Ser Asn Cys Pro Glu Glu Gln Leu Asp Ser Leu 
        115                 120                 125             


Glu Glu Val Gln Phe Phe Ala Asn Thr Ser Gly Ser Phe Leu Cys Val 
    130                 135                 140                 


Tyr Ser Leu Asn Ser Phe Asn Tyr Thr His Ser Pro Lys Ala Asp Ser 
145                 150                 155                 160 


Leu Cys Pro Arg Leu Pro Val Pro Pro Ser Lys Ser Phe Pro Leu Phe 
                165                 170                 175     


Asn Arg Cys Val Pro Gln Thr Pro Glu Cys Tyr Ser Leu Phe Ala Ser 
            180                 185                 190         


Val Leu Ile Asn Asp Val Asp Thr Leu His Arg Ile Leu Ser Gly Ile 
        195                 200                 205             


Met Ser Gly Arg Asp Thr Ile Leu Gly Leu Cys Ile Leu Ala Leu Ala 
    210                 215                 220                 


Leu Ser Leu Ala Met Met Phe Thr Phe Arg Phe Ile Thr Thr Leu Leu 
225                 230                 235                 240 


Val His Ile Phe Ile Ser Leu Val Ile Leu Gly Leu Leu Phe Val Cys 
                245                 250                 255     


Gly Val Leu Trp Trp Leu Tyr Tyr Asp Tyr Thr Asn Asp Leu Ser Ile 
            260                 265                 270         


Glu Leu Asp Thr Glu Arg Glu Asn Met Lys Cys Val Leu Gly Phe Ala 
        275                 280                 285             


Ile Val Ser Thr Gly Ile Thr Ala Val Leu Leu Val Leu Ile Phe Val 
    290                 295                 300                 


Leu Arg Lys Arg Ile Lys Leu Thr Val Glu Leu Phe Gln Ile Thr Asn 
305                 310                 315                 320 


Lys Ala Ile Ser Ser Ala Pro Phe Leu Leu Phe Gln Pro Leu Trp Thr 
                325                 330                 335     


Phe Ala Ile Leu Ile Phe Phe Trp Val Leu Trp Val Ala Val Leu Leu 
            340                 345                 350         


Ser Leu Gly Thr Ala Gly Ala Ala Gln Val Met Glu Gly Gly Gln Val 
        355                 360                 365             


Glu Tyr Lys Pro Leu Ser Gly Ile Arg Tyr Met Trp Ser Tyr His Leu 
    370                 375                 380                 


Ile Gly Leu Ile Trp Thr Ser Glu Phe Ile Leu Ala Cys Gln Gln Met 
385                 390                 395                 400 


Thr Ile Ala Gly Ala Val Val Thr Cys Tyr Phe Asn Arg Ser Lys Asn 
                405                 410                 415     


Asp Pro Pro Asp His Pro Ile Leu Ser Ser Leu Ser Ile Leu Phe Phe 
            420                 425                 430         


Tyr His Gln Gly Thr Val Val Lys Gly Ser Phe Leu Ile Ser Val Val 
        435                 440                 445             


Arg Ile Pro Arg Ile Ile Val Met Tyr Met Gln Asn Ala Leu Lys Glu 
    450                 455                 460                 


Gln Gln His Gly Ala Leu Ser Arg Tyr Leu Phe Arg Cys Cys Tyr Cys 
465                 470                 475                 480 


Cys Phe Trp Cys Leu Asp Lys Tyr Leu Leu His Leu Asn Gln Asn Ala 
                485                 490                 495     


Tyr Thr Thr Thr Ala Ile Asn Gly Thr Asp Phe Cys Thr Ser Ala Lys 
            500                 505                 510         


Asp Ala Phe Lys Ile Leu Ser Lys Asn Ser Ser His Phe Thr Ser Ile 
        515                 520                 525             


Asn Cys Phe Gly Asp Phe Ile Ile Phe Leu Gly Lys Val Leu Val Val 
    530                 535                 540                 


Cys Phe Thr Val Phe Gly Gly Leu Met Ala Phe Asn Tyr Asn Arg Ala 
545                 550                 555                 560 


Phe Gln Val Trp Ala Val Pro Leu Leu Leu Val Ala Phe Phe Ala Tyr 
                565                 570                 575     


Leu Val Ala His Ser Phe Leu Ser Val Phe Glu Thr Val Leu Asp Ala 
            580                 585                 590         


Leu Phe Leu Cys Phe Ala Val Asp Leu Glu Thr Asn Asp Gly Ser Ser 
        595                 600                 605             


Glu Lys Pro Tyr Phe Met Asp Gln Glu Phe Leu Ser Phe Val Lys Arg 
    610                 615                 620                 


Ser Asn Lys Leu Asn Asn Ala Arg Ala Gln Gln Asp Lys His Ser Leu 
625                 630                 635                 640 


Arg Asn Glu Glu Gly Thr Glu Leu Gln Ala Ile Val Arg 
                645                 650             


<210>  1269
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  1269

Met Lys Thr Lys Leu Asn Ile Tyr Asn Met Gln Phe Leu Leu Phe Val 
1               5                   10                  15      


Phe Leu Val Trp Asp Pro Ala Arg Leu Val Leu Ala Asn Ile Gln Glu 
            20                  25                  30          


Asp Glu Ala Lys Asn Asn Ile Thr Ile Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Asp Ser 
    50                  55                  60                  


Ile Thr Glu Val Phe Thr Asn Ile Tyr Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp Thr Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Lys 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Asn Ile Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Gln Asp Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Gln Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ser Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Thr Ser 
            180                 185                 190         


Glu Val Thr Tyr Ile Trp Thr Tyr Asn Ala Ser Asp Ser Val Gln Val 
        195                 200                 205             


Ala Pro Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Ser 
    210                 215                 220                 


Ile Gly Lys Glu Thr Ile Lys Ser Ser Thr Gly Glu Tyr Thr Val Met 
225                 230                 235                 240 


Thr Ala His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285             


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300                 


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320 


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335     


Phe Thr Lys Arg Gly Trp Ala Trp Asp Gly Lys Ser Val Val Asn Asp 
            340                 345                 350         


Lys Lys Lys Glu Lys Ala Ser Val Met Ile Gln Asn Asn Ala Tyr Ala 
        355                 360                 365             


Val Ala Val Ala Asn Tyr Ala Pro Asn Leu Ser Lys Asp Pro Val Leu 
    370                 375                 380                 


Ser Thr Ile Ser Lys Ser Ala Thr Thr Pro Glu Pro Asn Lys Lys Pro 
385                 390                 395                 400 


Glu Asn Lys Pro Ala Glu Ala Lys Lys Thr Phe Asn Ser Val Ser Lys 
                405                 410                 415     


Ile Asp Arg Met Ser Arg Ile Val Phe Pro Val Leu Phe Gly Thr Phe 
            420                 425                 430         


Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Val Leu Gly 
        435                 440                 445             


Val Ser Pro 
    450     


<210>  1270
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  1270

Met Gln His Ile Phe Ala Phe Phe Cys Thr Gly Phe Leu Gly Ala Val 
1               5                   10                  15      


Val Gly Ala Asn Phe Pro Asn Asn Ile Gln Ile Gly Gly Leu Phe Pro 
            20                  25                  30          


Asn Gln Gln Ser Gln Glu His Ala Ala Phe Arg Phe Ala Leu Ser Gln 
        35                  40                  45              


Leu Thr Glu Pro Pro Lys Leu Leu Pro Gln Ile Asp Ile Val Asn Ile 
    50                  55                  60                  


Ser Asp Ser Phe Glu Met Thr Tyr Arg Phe Cys Ser Gln Phe Ser Lys 
65                  70                  75                  80  


Gly Val Tyr Ala Ile Phe Gly Phe Tyr Glu Arg Arg Thr Val Asn Met 
                85                  90                  95      


Leu Thr Ser Phe Cys Gly Ala Leu His Val Cys Phe Ile Thr Pro Ser 
            100                 105                 110         


Phe Pro Val Asp Thr Ser Asn Gln Phe Val Leu Gln Leu Arg Pro Glu 
        115                 120                 125             


Leu Gln Asp Ala Leu Ile Ser Ile Ile Asp His Tyr Lys Trp Gln Lys 
    130                 135                 140                 


Phe Val Tyr Ile Tyr Asp Ala Asp Arg Gly Leu Ser Val Leu Gln Lys 
145                 150                 155                 160 


Val Leu Asp Thr Ala Ala Glu Lys Asn Trp Gln Val Thr Ala Val Asn 
                165                 170                 175     


Ile Leu Thr Thr Thr Glu Glu Gly Tyr Arg Met Leu Phe Gln Asp Leu 
            180                 185                 190         


Glu Lys Lys Lys Glu Arg Leu Val Val Val Asp Cys Glu Ser Glu Arg 
        195                 200                 205             


Leu Asn Ala Ile Leu Gly Gln Ile Ile Lys Leu Glu Lys Asn Gly Ile 
    210                 215                 220                 


Gly Tyr His Tyr Ile Leu Ala Asn Leu Gly Phe Met Asp Ile Asp Leu 
225                 230                 235                 240 


Asn Lys Phe Lys Glu Ser Gly Ala Asn Val Thr Gly Phe Gln Leu Val 
                245                 250                 255     


Asn Tyr Thr Asp Thr Ile Pro Ala Lys Ile Met Gln Gln Trp Lys Asn 
            260                 265                 270         


Ser Asp Ala Arg Asp His Thr Arg Val Asp Trp Lys Arg Pro Lys Tyr 
        275                 280                 285             


Thr Ser Ala Leu Thr Tyr Asp Gly Val Lys Val Met Ala Glu Ala Phe 
    290                 295                 300                 


Gln Ser Leu Arg Arg Gln Arg Ile Asp Ile Ser Arg Arg Gly Asn Ala 
305                 310                 315                 320 


Gly Asp Cys Leu Ala Asn Pro Ala Val Pro Trp Gly Gln Gly Ile Asp 
                325                 330                 335     


Ile Gln Arg Ala Leu Gln Gln Val Arg Phe Glu Gly Leu Thr Gly Asn 
            340                 345                 350         


Val Gln Phe Asn Glu Lys Gly Arg Arg Thr Asn Tyr Thr Leu His Val 
        355                 360                 365             


Ile Glu Met Lys His Asp Gly Ile Arg Lys Ile Gly Tyr Trp Asn Glu 
    370                 375                 380                 


Asp Asp Lys Phe Val Pro Ala Ala Thr Asp Ala Gln Ala Gly Gly Asp 
385                 390                 395                 400 


Asn Ser Ser Val Gln Asn Arg Thr Tyr Ile Val Thr Thr Ile Leu Glu 
                405                 410                 415     


Asp Pro Tyr Val Met Leu Lys Lys Asn Ala Asn Gln Phe Glu Gly Asn 
            420                 425                 430         


Asp Arg Tyr Glu Gly Tyr Cys Val Glu Leu Ala Ala Glu Ile Ala Lys 
        435                 440                 445             


His Val Gly Tyr Ser Tyr Arg Leu Glu Ile Val Ser Asp Gly Lys Tyr 
    450                 455                 460                 


Gly Ala Arg Asp Pro Asp Thr Lys Ala Trp Asn Gly Met Val Gly Glu 
465                 470                 475                 480 


Leu Val Tyr Gly Arg Ala Asp Val Ala Val Ala Pro Leu Thr Ile Thr 
                485                 490                 495     


Leu Val Arg Glu Glu Val Ile Asp Phe Ser Lys Pro Phe Met Ser Leu 
            500                 505                 510         


Gly Ile Ser Ile Met Ile Lys Lys Pro Gln Lys Ser Lys Pro Gly Val 
        515                 520                 525             


Phe Ser Phe Leu Asp Pro Leu Ala Tyr Glu Ile Trp Met Cys Ile Val 
    530                 535                 540                 


Phe Ala Tyr Ile Gly Val Ser Val Val Leu Phe Leu Val Ser Arg Phe 
545                 550                 555                 560 


Ser Pro Tyr Glu Trp His Ser Glu Glu Phe Glu Glu Gly Arg Asp Gln 
                565                 570                 575     


Thr Thr Ser Asp Gln Ser Asn Glu Phe Gly Ile Phe Asn Ser Leu Trp 
            580                 585                 590         


Phe Ser Leu Gly Ala Phe Met Gln Gln Gly Cys Asp Ile Ser Pro Arg 
        595                 600                 605             


Ser Leu Ser Gly Arg Ile Val Gly Gly Val Trp Trp Phe Phe Thr Leu 
    610                 615                 620                 


Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu Thr Val 
625                 630                 635                 640 


Glu Arg Met Val Ser Pro Ile Glu Ser Ala Glu Asp Leu Ala Lys Gln 
                645                 650                 655     


Thr Glu Ile Ala Tyr Gly Thr Leu Glu Ala Gly Ser Thr Lys Glu Phe 
            660                 665                 670         


Phe Arg Arg Ser Lys Ile Ala Val Phe Glu Lys Met Trp Thr Tyr Met 
        675                 680                 685             


Lys Ser Ala Glu Pro Ser Val Phe Val Arg Thr Thr Glu Glu Gly Met 
    690                 695                 700                 


Ile Arg Val Arg Lys Ser Lys Gly Lys Tyr Ala Tyr Leu Leu Glu Ser 
705                 710                 715                 720 


Thr Met Asn Glu Tyr Ile Glu Gln Arg Lys Pro Cys Asp Thr Met Lys 
                725                 730                 735     


Val Gly Gly Asn Leu Asp Ser Lys Gly Tyr Gly Ile Ala Thr Pro Lys 
            740                 745                 750         


Gly Ser Ala Leu Arg Gly Pro Val Asn Leu Ala Val Leu Lys Leu Ser 
        755                 760                 765             


Glu Gln Gly Val Leu Asp Lys Leu Lys Ser Lys Trp Trp Tyr Asp Lys 
    770                 775                 780                 


Gly Glu Cys Gly Ser Lys Asp Ser Gly Ser Lys Asp Lys Thr Ser Ala 
785                 790                 795                 800 


Leu Ser Leu Ser Asn Val Ala Gly Val Phe Tyr Ile Leu Ile Gly Gly 
                805                 810                 815     


Leu Gly Leu Ala Met Leu Val Ala Leu Ile Glu Phe Cys Tyr Lys Ser 
            820                 825                 830         


Arg Ser Glu Ser Lys Arg Met Lys Gly Phe Cys Leu Ile Pro Gln Gln 
        835                 840                 845             


Ser Ile Asn Glu Ala Ile Arg Thr Ser Thr Leu Pro Arg Asn Ser Gly 
    850                 855                 860                 


Ala Gly Ala Ser Ser Gly Gly Ser Gly Glu Asn Gly Arg Val Val Ser 
865                 870                 875                 880 


His Asp Phe Pro Lys Ser Met Gln Ser Ile Pro Cys Met Ser His Ser 
                885                 890                 895     


Ser Gly Met Pro Leu Gly Ala Thr Gly Leu 
            900                 905     


<210>  1271
<211>  1194
<212>  PRT
<213>  Homo sapiens

<400>  1271

Met Val Gly Leu Leu Leu Phe Phe Phe Pro Ala Ile Phe Leu Glu Val 
1               5                   10                  15      


Ser Leu Leu Pro Arg Ser Pro Gly Arg Lys Val Leu Leu Ala Gly Ala 
            20                  25                  30          


Ser Ser Gln Arg Ser Val Ala Arg Met Asp Gly Asp Val Ile Ile Gly 
        35                  40                  45              


Ala Leu Phe Ser Val His His Gln Pro Pro Ala Glu Lys Val Pro Glu 
    50                  55                  60                  


Arg Lys Cys Gly Glu Ile Arg Glu Gln Tyr Gly Ile Gln Arg Val Glu 
65                  70                  75                  80  


Ala Met Phe His Thr Leu Asp Lys Ile Asn Ala Asp Pro Val Leu Leu 
                85                  90                  95      


Pro Asn Ile Thr Leu Gly Ser Glu Ile Arg Asp Ser Cys Trp His Ser 
            100                 105                 110         


Ser Val Ala Leu Glu Gln Ser Ile Glu Phe Ile Arg Asp Ser Leu Ile 
        115                 120                 125             


Ser Ile Arg Asp Glu Lys Asp Gly Ile Asn Arg Cys Leu Pro Asp Gly 
    130                 135                 140                 


Gln Ser Leu Pro Pro Gly Arg Thr Lys Lys Pro Ile Ala Gly Val Ile 
145                 150                 155                 160 


Gly Pro Gly Ser Ser Ser Val Ala Ile Gln Val Gln Asn Leu Leu Gln 
                165                 170                 175     


Leu Phe Asp Ile Pro Gln Ile Ala Tyr Ser Ala Thr Ser Ile Asp Leu 
            180                 185                 190         


Ser Asp Lys Thr Leu Tyr Lys Tyr Phe Leu Arg Val Val Pro Ser Asp 
        195                 200                 205             


Thr Leu Gln Ala Arg Ala Met Leu Asp Ile Val Lys Arg Tyr Asn Trp 
    210                 215                 220                 


Thr Tyr Val Ser Ala Val His Thr Glu Gly Asn Tyr Gly Glu Ser Gly 
225                 230                 235                 240 


Met Asp Ala Phe Lys Glu Leu Ala Ala Gln Glu Gly Leu Cys Ile Ala 
                245                 250                 255     


His Ser Asp Lys Ile Tyr Ser Asn Ala Gly Glu Lys Ser Phe Asp Arg 
            260                 265                 270         


Leu Leu Arg Lys Leu Arg Glu Arg Leu Pro Lys Ala Arg Val Val Val 
        275                 280                 285             


Cys Phe Cys Glu Gly Met Thr Val Arg Gly Leu Leu Ser Ala Met Arg 
    290                 295                 300                 


Arg Leu Gly Val Val Gly Glu Phe Ser Leu Ile Gly Ser Asp Gly Trp 
305                 310                 315                 320 


Ala Asp Arg Asp Glu Val Ile Glu Gly Tyr Glu Val Glu Ala Asn Gly 
                325                 330                 335     


Gly Ile Thr Ile Lys Leu Gln Ser Pro Glu Val Arg Ser Phe Asp Asp 
            340                 345                 350         


Tyr Phe Leu Lys Leu Arg Leu Asp Thr Asn Thr Arg Asn Pro Trp Phe 
        355                 360                 365             


Pro Glu Phe Trp Gln His Arg Phe Gln Cys Arg Leu Pro Gly His Leu 
    370                 375                 380                 


Leu Glu Asn Pro Asn Phe Lys Arg Ile Cys Thr Gly Asn Glu Ser Leu 
385                 390                 395                 400 


Glu Glu Asn Tyr Val Gln Asp Ser Lys Met Gly Phe Val Ile Asn Ala 
                405                 410                 415     


Ile Tyr Ala Met Ala His Gly Leu Gln Asn Met His His Ala Leu Cys 
            420                 425                 430         


Pro Gly His Val Gly Leu Cys Asp Ala Met Lys Pro Ile Asp Gly Ser 
        435                 440                 445             


Lys Leu Leu Asp Phe Leu Ile Lys Ser Ser Phe Ile Gly Val Ser Gly 
    450                 455                 460                 


Glu Glu Val Trp Phe Asp Glu Lys Gly Asp Ala Pro Gly Arg Tyr Asp 
465                 470                 475                 480 


Ile Met Asn Leu Gln Tyr Thr Glu Ala Asn Arg Tyr Asp Tyr Val His 
                485                 490                 495     


Val Gly Thr Trp His Glu Gly Val Leu Asn Ile Asp Asp Tyr Lys Ile 
            500                 505                 510         


Gln Met Asn Lys Ser Gly Val Val Arg Ser Val Cys Ser Glu Pro Cys 
        515                 520                 525             


Leu Lys Gly Gln Ile Lys Val Ile Arg Lys Gly Glu Val Ser Cys Cys 
    530                 535                 540                 


Trp Ile Cys Thr Ala Cys Lys Glu Asn Glu Tyr Val Gln Asp Glu Phe 
545                 550                 555                 560 


Thr Cys Lys Ala Cys Asp Leu Gly Trp Trp Pro Asn Ala Asp Leu Thr 
                565                 570                 575     


Gly Cys Glu Pro Ile Pro Val Arg Tyr Leu Glu Trp Ser Asn Ile Glu 
            580                 585                 590         


Ser Ile Ile Ala Ile Ala Phe Ser Cys Leu Gly Ile Leu Val Thr Leu 
        595                 600                 605             


Phe Val Thr Leu Ile Phe Val Leu Tyr Arg Asp Thr Pro Val Val Lys 
    610                 615                 620                 


Ser Ser Ser Arg Glu Leu Cys Tyr Ile Ile Leu Ala Gly Ile Phe Leu 
625                 630                 635                 640 


Gly Tyr Val Cys Pro Phe Thr Leu Ile Ala Lys Pro Thr Thr Thr Ser 
                645                 650                 655     


Cys Tyr Leu Gln Arg Leu Leu Val Gly Leu Ser Ser Ala Met Cys Tyr 
            660                 665                 670         


Ser Ala Leu Val Thr Lys Thr Asn Arg Ile Ala Arg Ile Leu Ala Gly 
        675                 680                 685             


Ser Lys Lys Lys Ile Cys Thr Arg Lys Pro Arg Phe Met Ser Ala Trp 
    690                 695                 700                 


Ala Gln Val Ile Ile Ala Ser Ile Leu Ile Ser Val Gln Leu Thr Leu 
705                 710                 715                 720 


Val Val Thr Leu Ile Ile Met Glu Pro Pro Met Pro Ile Leu Ser Tyr 
                725                 730                 735     


Pro Ser Ile Lys Glu Val Tyr Leu Ile Cys Asn Thr Ser Asn Leu Gly 
            740                 745                 750         


Val Val Ala Pro Leu Gly Tyr Asn Gly Leu Leu Ile Met Ser Cys Thr 
        755                 760                 765             


Tyr Tyr Ala Phe Lys Thr Arg Asn Val Pro Ala Asn Phe Asn Glu Ala 
    770                 775                 780                 


Lys Tyr Ile Ala Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala 
785                 790                 795                 800 


Phe Val Pro Ile Tyr Phe Gly Ser Asn Tyr Lys Ile Ile Thr Thr Cys 
                805                 810                 815     


Phe Ala Val Ser Leu Ser Val Thr Val Ala Leu Gly Cys Met Phe Thr 
            820                 825                 830         


Pro Lys Met Tyr Ile Ile Ile Ala Lys Pro Glu Arg Asn Val Arg Ser 
        835                 840                 845             


Ala Phe Thr Thr Ser Asp Val Val Arg Met His Val Gly Asp Gly Lys 
    850                 855                 860                 


Leu Pro Cys Arg Ser Asn Thr Phe Leu Asn Ile Phe Arg Arg Lys Lys 
865                 870                 875                 880 


Ala Gly Ala Gly Asn Ala Asn Ser Asn Gly Lys Ser Val Ser Trp Ser 
                885                 890                 895     


Glu Pro Gly Gly Gly Gln Val Pro Lys Gly Gln His Met Trp His Arg 
            900                 905                 910         


Leu Ser Val His Val Lys Thr Asn Glu Thr Ala Cys Asn Gln Thr Ala 
        915                 920                 925             


Val Ile Lys Pro Leu Thr Lys Ser Tyr Gln Gly Ser Gly Lys Ser Leu 
    930                 935                 940                 


Thr Phe Ser Asp Thr Ser Thr Lys Thr Leu Tyr Asn Val Glu Glu Glu 
945                 950                 955                 960 


Glu Asp Ala Gln Pro Ile Arg Phe Ser Pro Pro Gly Ser Pro Ser Met 
                965                 970                 975     


Val Val His Arg Arg Val Pro Ser Ala Ala Thr Thr Pro Pro Leu Pro 
            980                 985                 990         


Ser His Leu Thr Ala Glu Glu Thr  Pro Leu Phe Leu Ala  Glu Pro Ala 
        995                 1000                 1005             


Leu Pro  Lys Gly Leu Pro Pro  Pro Leu Gln Gln Gln  Gln Gln Pro 
    1010                 1015                 1020             


Pro Pro  Gln Gln Lys Ser Leu  Met Asp Gln Leu Gln  Gly Val Val 
    1025                 1030                 1035             


Ser Asn  Phe Ser Thr Ala Ile  Pro Asp Phe His Ala  Val Leu Ala 
    1040                 1045                 1050             


Gly Pro  Gly Gly Pro Gly Asn  Gly Leu Arg Ser Leu  Tyr Pro Pro 
    1055                 1060                 1065             


Pro Pro  Pro Pro Gln His Leu  Gln Met Leu Pro Leu  Gln Leu Ser 
    1070                 1075                 1080             


Thr Phe  Gly Glu Glu Leu Val  Ser Pro Pro Ala Asp  Asp Asp Asp 
    1085                 1090                 1095             


Asp Ser  Glu Arg Phe Lys Leu  Leu Gln Glu Tyr Val  Tyr Glu His 
    1100                 1105                 1110             


Glu Arg  Glu Gly Asn Thr Glu  Glu Asp Glu Leu Glu  Glu Glu Glu 
    1115                 1120                 1125             


Glu Asp  Leu Gln Ala Ala Ser  Lys Leu Thr Pro Asp  Asp Ser Pro 
    1130                 1135                 1140             


Ala Leu  Thr Pro Pro Ser Pro  Phe Arg Asp Ser Val  Ala Ser Gly 
    1145                 1150                 1155             


Ser Ser  Val Pro Ser Ser Pro  Val Ser Glu Ser Val  Leu Cys Thr 
    1160                 1165                 1170             


Pro Pro  Asn Val Ser Tyr Ala  Ser Val Ile Leu Arg  Asp Tyr Lys 
    1175                 1180                 1185             


Gln Ser  Ser Ser Thr Leu 
    1190                 


<210>  1272
<211>  781
<212>  PRT
<213>  Homo sapiens

<400>  1272

Met Ala Asn Val Ser Lys Lys Val Ser Trp Ser Gly Arg Asp Arg Asp 
1               5                   10                  15      


Asp Glu Glu Ala Ala Pro Leu Leu Arg Arg Thr Ala Arg Pro Gly Gly 
            20                  25                  30          


Gly Thr Pro Leu Leu Asn Gly Ala Gly Pro Gly Ala Ala Arg Gln Asp 
        35                  40                  45              


Met Asp Pro Pro His Pro Phe Pro Lys Glu Ile Pro His Asn Glu Lys 
    50                  55                  60                  


Leu Leu Ser Leu Lys Tyr Glu Ser Leu Asp Tyr Asp Asn Ser Glu Asn 
65                  70                  75                  80  


Gln Leu Phe Leu Glu Glu Glu Arg Arg Ile Asn His Thr Ala Phe Arg 
                85                  90                  95      


Thr Val Glu Ile Lys Arg Trp Val Ile Cys Ala Leu Ile Gly Ile Leu 
            100                 105                 110         


Thr Gly Leu Val Ala Cys Phe Ile Asp Ile Val Val Glu Asn Leu Ala 
        115                 120                 125             


Gly Leu Lys Tyr Arg Val Ile Lys Gly Asn Ile Asp Lys Phe Thr Glu 
    130                 135                 140                 


Lys Gly Gly Leu Ser Phe Ser Leu Leu Leu Trp Ala Thr Leu Asn Ala 
145                 150                 155                 160 


Ala Phe Val Leu Val Gly Ser Val Ile Val Ala Phe Ile Glu Pro Val 
                165                 170                 175     


Ala Ala Gly Ser Gly Ile Pro Gln Ile Lys Cys Phe Leu Asn Gly Val 
            180                 185                 190         


Lys Ile Pro His Val Val Arg Leu Lys Thr Leu Val Ile Lys Val Ser 
        195                 200                 205             


Gly Val Ile Leu Ser Val Val Gly Gly Leu Ala Val Gly Lys Glu Gly 
    210                 215                 220                 


Pro Met Ile His Ser Gly Ser Val Ile Ala Ala Gly Ile Ser Gln Gly 
225                 230                 235                 240 


Arg Ser Thr Ser Leu Lys Arg Asp Phe Lys Ile Phe Glu Tyr Phe Arg 
                245                 250                 255     


Arg Asp Thr Glu Lys Arg Asp Phe Val Ser Ala Gly Ala Ala Ala Gly 
            260                 265                 270         


Val Ser Ala Ala Phe Gly Ala Pro Val Gly Gly Val Leu Phe Ser Leu 
        275                 280                 285             


Glu Glu Gly Ala Ser Phe Trp Asn Gln Phe Leu Thr Trp Arg Ile Phe 
    290                 295                 300                 


Phe Ala Ser Met Ile Ser Thr Phe Thr Leu Asn Phe Val Leu Ser Ile 
305                 310                 315                 320 


Tyr His Gly Asn Met Trp Asp Leu Ser Ser Pro Gly Leu Ile Asn Phe 
                325                 330                 335     


Gly Arg Phe Asp Ser Glu Lys Met Ala Tyr Thr Ile His Glu Ile Pro 
            340                 345                 350         


Val Phe Ile Ala Met Gly Val Val Gly Gly Val Leu Gly Ala Val Phe 
        355                 360                 365             


Asn Ala Leu Asn Tyr Trp Leu Thr Met Phe Arg Ile Arg Tyr Ile His 
    370                 375                 380                 


Arg Pro Cys Leu Gln Val Ile Glu Ala Val Leu Val Ala Ala Val Thr 
385                 390                 395                 400 


Ala Thr Val Ala Phe Val Leu Ile Tyr Ser Ser Arg Asp Cys Gln Pro 
                405                 410                 415     


Leu Gln Gly Gly Ser Met Ser Tyr Pro Leu Gln Leu Phe Cys Ala Asp 
            420                 425                 430         


Gly Glu Tyr Asn Ser Met Ala Ala Ala Phe Phe Asn Thr Pro Glu Lys 
        435                 440                 445             


Ser Val Val Ser Leu Phe His Asp Pro Pro Gly Ser Tyr Asn Pro Leu 
    450                 455                 460                 


Thr Leu Gly Leu Phe Thr Leu Val Tyr Phe Phe Leu Ala Cys Trp Thr 
465                 470                 475                 480 


Tyr Gly Leu Thr Val Ser Ala Gly Val Phe Ile Pro Ser Leu Leu Ile 
                485                 490                 495     


Gly Ala Ala Trp Gly Arg Leu Phe Gly Ile Ser Leu Ser Tyr Leu Thr 
            500                 505                 510         


Gly Ala Ala Ile Trp Ala Asp Pro Gly Lys Tyr Ala Leu Met Gly Ala 
        515                 520                 525             


Ala Ala Gln Leu Gly Gly Ile Val Arg Met Thr Leu Ser Leu Thr Val 
    530                 535                 540                 


Ile Met Met Glu Ala Thr Ser Asn Val Thr Tyr Gly Phe Pro Ile Met 
545                 550                 555                 560 


Leu Val Leu Met Thr Ala Lys Ile Val Gly Asp Val Phe Ile Glu Gly 
                565                 570                 575     


Leu Tyr Asp Met His Ile Gln Leu Gln Ser Val Pro Phe Leu His Trp 
            580                 585                 590         


Glu Ala Pro Val Thr Ser His Ser Leu Thr Ala Arg Glu Val Met Ser 
        595                 600                 605             


Thr Pro Val Thr Cys Leu Arg Arg Arg Glu Lys Val Gly Val Ile Val 
    610                 615                 620                 


Asp Val Leu Ser Asp Thr Ala Ser Asn His Asn Gly Phe Pro Val Val 
625                 630                 635                 640 


Glu His Ala Asp Asp Thr Gln Pro Ala Arg Leu Gln Gly Leu Ile Leu 
                645                 650                 655     


Arg Ser Gln Leu Ile Val Leu Leu Lys His Lys Val Phe Val Glu Arg 
            660                 665                 670         


Ser Asn Leu Gly Leu Val Gln Arg Arg Leu Arg Leu Lys Asp Phe Arg 
        675                 680                 685             


Asp Ala Tyr Pro Arg Phe Pro Pro Ile Gln Ser Ile His Val Ser Gln 
    690                 695                 700                 


Asp Glu Arg Glu Cys Thr Met Asp Leu Ser Glu Phe Met Asn Pro Ser 
705                 710                 715                 720 


Pro Tyr Thr Val Pro Gln Glu Ala Ser Leu Pro Arg Val Phe Lys Leu 
                725                 730                 735     


Phe Arg Ala Leu Gly Leu Arg His Leu Val Val Val Asp Asn Arg Asn 
            740                 745                 750         


Gln Val Val Gly Leu Val Thr Arg Lys Asp Leu Ala Arg Tyr Arg Leu 
        755                 760                 765             


Gly Lys Arg Gly Leu Glu Glu Leu Ser Leu Ala Gln Thr 
    770                 775                 780     


<210>  1273
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  1273

Met Ala Val Phe Lys Thr Thr Leu Trp Arg Leu Ile Ser Gly Thr Leu 
1               5                   10                  15      


Gly Ile Ile Cys Leu Ser Leu Met Ala Thr Leu Gly Ile Leu Leu Lys 
            20                  25                  30          


Asn Ser Phe Thr Lys Leu Ser Ile Glu Pro Ala Phe Thr Pro Gly Pro 
        35                  40                  45              


Asn Ile Glu Leu Gln Lys Asp Ser Asp Cys Cys Ser Cys Gln Glu Lys 
    50                  55                  60                  


Trp Val Gly Tyr Arg Cys Asn Cys Tyr Phe Ile Ser Ser Glu Gln Lys 
65                  70                  75                  80  


Thr Trp Asn Glu Ser Arg His Leu Cys Ala Ser Gln Lys Ser Ser Leu 
                85                  90                  95      


Leu Gln Leu Gln Asn Thr Asp Glu Leu Asp Phe Met Ser Ser Ser Gln 
            100                 105                 110         


Gln Phe Tyr Trp Ile Gly Leu Ser Tyr Ser Glu Glu His Thr Ala Trp 
        115                 120                 125             


Leu Trp Glu Asn Gly Ser Ala Leu Ser Gln Tyr Leu Phe Pro Ser Phe 
    130                 135                 140                 


Glu Thr Phe Asn Thr Lys Asn Cys Ile Ala Tyr Asn Pro Asn Gly Asn 
145                 150                 155                 160 


Ala Leu Asp Glu Ser Cys Glu Asp Lys Asn Arg Tyr Ile Cys Lys Gln 
                165                 170                 175     


Gln Leu Ile 
            


<210>  1274
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  1274

Met Leu Lys Lys Gln Ser Ala Gly Leu Val Leu Trp Gly Ala Ile Leu 
1               5                   10                  15      


Phe Val Ala Trp Asn Ala Leu Leu Leu Leu Phe Phe Trp Thr Arg Pro 
            20                  25                  30          


Ala Pro Gly Arg Pro Pro Ser Val Ser Ala Leu Asp Gly Asp Pro Ala 
        35                  40                  45              


Ser Leu Thr Arg Glu Val Ile Arg Leu Ala Gln Asp Ala Glu Val Glu 
    50                  55                  60                  


Leu Glu Arg Gln Arg Gly Leu Leu Gln Gln Ile Gly Asp Ala Leu Ser 
65                  70                  75                  80  


Ser Gln Arg Gly Arg Val Pro Thr Ala Ala Pro Pro Ala Gln Pro Arg 
                85                  90                  95      


Val Pro Val Thr Pro Ala Pro Ala Val Ile Pro Ile Leu Val Ile Ala 
            100                 105                 110         


Cys Asp Arg Ser Thr Val Arg Arg Cys Leu Asp Lys Leu Leu His Tyr 
        115                 120                 125             


Arg Pro Ser Ala Glu Leu Phe Pro Ile Ile Val Ser Gln Asp Cys Gly 
    130                 135                 140                 


His Glu Glu Thr Ala Gln Ala Ile Ala Ser Tyr Gly Ser Ala Val Thr 
145                 150                 155                 160 


His Ile Arg Gln Pro Asp Leu Ser Ser Ile Ala Val Pro Pro Asp His 
                165                 170                 175     


Arg Lys Phe Gln Gly Tyr Tyr Lys Ile Ala Arg His Tyr Arg Trp Ala 
            180                 185                 190         


Leu Gly Gln Val Phe Arg Gln Phe Arg Phe Pro Ala Ala Val Val Val 
        195                 200                 205             


Glu Asp Asp Leu Glu Val Ala Pro Asp Phe Phe Glu Tyr Phe Arg Ala 
    210                 215                 220                 


Thr Tyr Pro Leu Leu Lys Ala Asp Pro Ser Leu Trp Cys Val Ser Ala 
225                 230                 235                 240 


Trp Asn Asp Asn Gly Lys Glu Gln Met Val Asp Ala Ser Arg Pro Glu 
                245                 250                 255     


Leu Leu Tyr Arg Thr Asp Phe Phe Pro Gly Leu Gly Trp Leu Leu Leu 
            260                 265                 270         


Ala Glu Leu Trp Ala Glu Leu Glu Pro Lys Trp Pro Lys Ala Phe Trp 
        275                 280                 285             


Asp Asp Trp Met Arg Arg Pro Glu Gln Arg Gln Gly Arg Ala Cys Ile 
    290                 295                 300                 


Arg Pro Glu Ile Ser Arg Thr Met Thr Phe Gly Arg Lys Gly Val Ser 
305                 310                 315                 320 


His Gly Gln Phe Phe Asp Gln His Leu Lys Phe Ile Lys Leu Asn Gln 
                325                 330                 335     


Gln Phe Val His Phe Thr Gln Leu Asp Leu Ser Tyr Leu Gln Arg Glu 
            340                 345                 350         


Ala Tyr Asp Arg Asp Phe Leu Ala Arg Val Tyr Gly Ala Pro Gln Leu 
        355                 360                 365             


Gln Val Glu Lys Val Arg Thr Asn Asp Arg Lys Glu Leu Gly Glu Val 
    370                 375                 380                 


Arg Val Gln Tyr Thr Gly Arg Asp Ser Phe Lys Ala Phe Ala Lys Ala 
385                 390                 395                 400 


Leu Gly Val Met Asp Asp Leu Lys Ser Gly Val Pro Arg Ala Gly Tyr 
                405                 410                 415     


Arg Gly Ile Val Thr Phe Gln Phe Arg Gly Arg Arg Val His Leu Ala 
            420                 425                 430         


Pro Pro Leu Thr Trp Glu Gly Tyr Asp Pro Ser Trp Asn 
        435                 440                 445 


<210>  1275
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  1275

Met Leu Lys Lys Gln Ser Ala Gly Leu Val Leu Trp Gly Ala Ile Leu 
1               5                   10                  15      


Phe Val Ala Trp Asn Ala Leu Leu Leu Leu Phe Phe Trp Thr Arg Pro 
            20                  25                  30          


Ala Pro Gly Arg Pro Pro Ser Val Ser Ala Leu Asp Gly Asp Pro Ala 
        35                  40                  45              


Ser Leu Thr Arg Glu Val Ile Arg Leu Ala Gln Asp Ala Glu Val Glu 
    50                  55                  60                  


Leu Glu Arg Gln Arg Gly Leu Leu Gln Gln Ile Gly Asp Ala Leu Ser 
65                  70                  75                  80  


Ser Gln Arg Gly Arg Val Pro Thr Ala Ala Pro Pro Ala Gln Pro Arg 
                85                  90                  95      


Val Pro Val Thr Pro Ala Pro Ala Val Ile Pro Ile Leu Val Ile Ala 
            100                 105                 110         


Cys Asp Arg Ser Thr Val Arg Arg Cys Leu Asp Lys Leu Leu His Tyr 
        115                 120                 125             


Arg Pro Ser Ala Glu Leu Phe Pro Ile Ile Val Ser Gln Asp Cys Gly 
    130                 135                 140                 


His Glu Glu Thr Ala Gln Ala Ile Ala Ser Tyr Gly Ser Ala Val Thr 
145                 150                 155                 160 


His Ile Arg Gln Pro Asp Leu Ser Ser Ile Ala Val Pro Pro Asp His 
                165                 170                 175     


Arg Lys Phe Gln Gly Tyr Tyr Lys Ile Ala Arg His Tyr Arg Trp Ala 
            180                 185                 190         


Leu Gly Gln Val Phe Arg Gln Phe Arg Phe Pro Ala Ala Val Val Val 
        195                 200                 205             


Glu Asp Asp Leu Glu Val Ala Pro Asp Phe Phe Glu Tyr Phe Arg Ala 
    210                 215                 220                 


Thr Tyr Pro Leu Leu Lys Ala Asp Pro Ser Leu Trp Cys Val Ser Ala 
225                 230                 235                 240 


Trp Asn Asp Asn Gly Lys Glu Gln Met Val Asp Ala Ser Arg Pro Glu 
                245                 250                 255     


Leu Leu Tyr Arg Thr Asp Phe Phe Pro Gly Leu Gly Trp Leu Leu Leu 
            260                 265                 270         


Ala Glu Leu Trp Ala Glu Leu Glu Pro Lys Trp Pro Lys Ala Phe Trp 
        275                 280                 285             


Asp Asp Trp Met Arg Arg Pro Glu Gln Arg Gln Gly Arg Ala Cys Ile 
    290                 295                 300                 


Arg Pro Glu Ile Ser Arg Thr Met Thr Phe Gly Arg Lys Gly Val Ser 
305                 310                 315                 320 


His Gly Gln Phe Phe Asp Gln His Leu Lys Phe Ile Lys Leu Asn Gln 
                325                 330                 335     


Gln Phe Val His Phe Thr Gln Leu Asp Leu Ser Tyr Leu Gln Arg Glu 
            340                 345                 350         


Ala Tyr Asp Arg Asp Phe Leu Ala Arg Val Tyr Gly Ala Pro Gln Leu 
        355                 360                 365             


Gln Val Glu Lys Val Arg Thr Asn Asp Arg Lys Glu Leu Gly Glu Val 
    370                 375                 380                 


Arg Val Gln Tyr Thr Gly Arg Asp Ser Phe Lys Ala Phe Ala Lys Ala 
385                 390                 395                 400 


Leu Gly Val Met Asp Asp Leu Lys Ser Gly Val Pro Arg Ala Gly Tyr 
                405                 410                 415     


Arg Gly Ile Val Thr Phe Gln Phe Arg Gly Arg Arg Val His Leu Ala 
            420                 425                 430         


Pro Pro Leu Thr Trp Glu Gly Tyr Asp Pro Ser Trp Asn 
        435                 440                 445 


<210>  1276
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  1276

Met Leu Lys Lys Gln Ser Ala Gly Leu Val Leu Trp Gly Ala Ile Leu 
1               5                   10                  15      


Phe Val Ala Trp Asn Ala Leu Leu Leu Leu Phe Phe Trp Thr Arg Pro 
            20                  25                  30          


Ala Pro Gly Arg Pro Pro Ser Val Ser Ala Leu Asp Gly Asp Pro Ala 
        35                  40                  45              


Ser Leu Thr Arg Glu Val Ile Arg Leu Ala Gln Asp Ala Glu Val Glu 
    50                  55                  60                  


Leu Glu Arg Gln Arg Gly Leu Leu Gln Gln Ile Gly Asp Ala Leu Ser 
65                  70                  75                  80  


Ser Gln Arg Gly Arg Val Pro Thr Ala Ala Pro Pro Ala Gln Pro Arg 
                85                  90                  95      


Val Pro Val Thr Pro Ala Pro Ala Val Ile Pro Ile Leu Val Ile Ala 
            100                 105                 110         


Cys Asp Arg Ser Thr Val Arg Arg Cys Leu Asp Lys Leu Leu His Tyr 
        115                 120                 125             


Arg Pro Ser Ala Glu Leu Phe Pro Ile Ile Val Ser Gln Asp Cys Gly 
    130                 135                 140                 


His Glu Glu Thr Ala Gln Ala Ile Ala Ser Tyr Gly Ser Ala Val Thr 
145                 150                 155                 160 


His Ile Arg Gln Pro Asp Leu Ser Ser Ile Ala Val Pro Pro Asp His 
                165                 170                 175     


Arg Lys Phe Gln Gly Tyr Tyr Lys Ile Ala Arg His Tyr Arg Trp Ala 
            180                 185                 190         


Leu Gly Gln Val Phe Arg Gln Phe Arg Phe Pro Ala Ala Val Val Val 
        195                 200                 205             


Glu Asp Asp Leu Glu Val Ala Pro Asp Phe Phe Glu Tyr Phe Arg Ala 
    210                 215                 220                 


Thr Tyr Pro Leu Leu Lys Ala Asp Pro Ser Leu Trp Cys Val Ser Ala 
225                 230                 235                 240 


Trp Asn Asp Asn Gly Lys Glu Gln Met Val Asp Ala Ser Arg Pro Glu 
                245                 250                 255     


Leu Leu Tyr Arg Thr Asp Phe Phe Pro Gly Leu Gly Trp Leu Leu Leu 
            260                 265                 270         


Ala Glu Leu Trp Ala Glu Leu Glu Pro Lys Trp Pro Lys Ala Phe Trp 
        275                 280                 285             


Asp Asp Trp Met Arg Arg Pro Glu Gln Arg Gln Gly Arg Ala Cys Ile 
    290                 295                 300                 


Arg Pro Glu Ile Ser Arg Thr Met Thr Phe Gly Arg Lys Gly Val Ser 
305                 310                 315                 320 


His Gly Gln Phe Phe Asp Gln His Leu Lys Phe Ile Lys Leu Asn Gln 
                325                 330                 335     


Gln Phe Val His Phe Thr Gln Leu Asp Leu Ser Tyr Leu Gln Arg Glu 
            340                 345                 350         


Ala Tyr Asp Arg Asp Phe Leu Ala Arg Val Tyr Gly Ala Pro Gln Leu 
        355                 360                 365             


Gln Val Glu Lys Val Arg Thr Asn Asp Arg Lys Glu Leu Gly Glu Val 
    370                 375                 380                 


Arg Val Gln Tyr Thr Gly Arg Asp Ser Phe Lys Ala Phe Ala Lys Ala 
385                 390                 395                 400 


Leu Gly Val Met Asp Asp Leu Lys Ser Gly Val Pro Arg Ala Gly Tyr 
                405                 410                 415     


Arg Gly Ile Val Thr Phe Gln Phe Arg Gly Arg Arg Val His Leu Ala 
            420                 425                 430         


Pro Pro Leu Thr Trp Glu Gly Tyr Asp Pro Ser Trp Asn 
        435                 440                 445 


<210>  1277
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  1277

Met Leu Lys Lys Gln Ser Ala Gly Leu Val Leu Trp Gly Ala Ile Leu 
1               5                   10                  15      


Phe Val Ala Trp Asn Ala Leu Leu Leu Leu Phe Phe Trp Thr Arg Pro 
            20                  25                  30          


Ala Pro Gly Arg Pro Pro Ser Val Ser Ala Leu Asp Gly Asp Pro Ala 
        35                  40                  45              


Ser Leu Thr Arg Glu Val Ile Arg Leu Ala Gln Asp Ala Glu Val Glu 
    50                  55                  60                  


Leu Glu Arg Gln Arg Gly Leu Leu Gln Gln Ile Gly Asp Ala Leu Ser 
65                  70                  75                  80  


Ser Gln Arg Gly Arg Val Pro Thr Ala Ala Pro Pro Ala Gln Pro Arg 
                85                  90                  95      


Val Pro Val Thr Pro Ala Pro Ala Val Ile Pro Ile Leu Val Ile Ala 
            100                 105                 110         


Cys Asp Arg Ser Thr Val Arg Arg Cys Leu Asp Lys Leu Leu His Tyr 
        115                 120                 125             


Arg Pro Ser Ala Glu Leu Phe Pro Ile Ile Val Ser Gln Asp Cys Gly 
    130                 135                 140                 


His Glu Glu Thr Ala Gln Ala Ile Ala Ser Tyr Gly Ser Ala Val Thr 
145                 150                 155                 160 


His Ile Arg Gln Pro Asp Leu Ser Ser Ile Ala Val Pro Pro Asp His 
                165                 170                 175     


Arg Lys Phe Gln Gly Tyr Tyr Lys Ile Ala Arg His Tyr Arg Trp Ala 
            180                 185                 190         


Leu Gly Gln Val Phe Arg Gln Phe Arg Phe Pro Ala Ala Val Val Val 
        195                 200                 205             


Glu Asp Asp Leu Glu Val Ala Pro Asp Phe Phe Glu Tyr Phe Arg Ala 
    210                 215                 220                 


Thr Tyr Pro Leu Leu Lys Ala Asp Pro Ser Leu Trp Cys Val Ser Ala 
225                 230                 235                 240 


Trp Asn Asp Asn Gly Lys Glu Gln Met Val Asp Ala Ser Arg Pro Glu 
                245                 250                 255     


Leu Leu Tyr Arg Thr Asp Phe Phe Pro Gly Leu Gly Trp Leu Leu Leu 
            260                 265                 270         


Ala Glu Leu Trp Ala Glu Leu Glu Pro Lys Trp Pro Lys Ala Phe Trp 
        275                 280                 285             


Asp Asp Trp Met Arg Arg Pro Glu Gln Arg Gln Gly Arg Ala Cys Ile 
    290                 295                 300                 


Arg Pro Glu Ile Ser Arg Thr Met Thr Phe Gly Arg Lys Gly Val Ser 
305                 310                 315                 320 


His Gly Gln Phe Phe Asp Gln His Leu Lys Phe Ile Lys Leu Asn Gln 
                325                 330                 335     


Gln Phe Val His Phe Thr Gln Leu Asp Leu Ser Tyr Leu Gln Arg Glu 
            340                 345                 350         


Ala Tyr Asp Arg Asp Phe Leu Ala Arg Val Tyr Gly Ala Pro Gln Leu 
        355                 360                 365             


Gln Val Glu Lys Val Arg Thr Asn Asp Arg Lys Glu Leu Gly Glu Val 
    370                 375                 380                 


Arg Val Gln Tyr Thr Gly Arg Asp Ser Phe Lys Ala Phe Ala Lys Ala 
385                 390                 395                 400 


Leu Gly Val Met Asp Asp Leu Lys Ser Gly Val Pro Arg Ala Gly Tyr 
                405                 410                 415     


Arg Gly Ile Val Thr Phe Gln Phe Arg Gly Arg Arg Val His Leu Ala 
            420                 425                 430         


Pro Pro Leu Thr Trp Glu Gly Tyr Asp Pro Ser Trp Asn 
        435                 440                 445 


<210>  1278
<211>  658
<212>  PRT
<213>  Homo sapiens

<400>  1278

Met Asp Arg Gly Thr Leu Pro Leu Ala Val Ala Leu Leu Leu Ala Ser 
1               5                   10                  15      


Cys Ser Leu Ser Pro Thr Ser Leu Ala Glu Thr Val His Cys Asp Leu 
            20                  25                  30          


Gln Pro Val Gly Pro Glu Arg Gly Glu Val Thr Tyr Thr Thr Ser Gln 
        35                  40                  45              


Val Ser Lys Gly Cys Val Ala Gln Ala Pro Asn Ala Ile Leu Glu Val 
    50                  55                  60                  


His Val Leu Phe Leu Glu Phe Pro Thr Gly Pro Ser Gln Leu Glu Leu 
65                  70                  75                  80  


Thr Leu Gln Ala Ser Lys Gln Asn Gly Thr Trp Pro Arg Glu Val Leu 
                85                  90                  95      


Leu Val Leu Ser Val Asn Ser Ser Val Phe Leu His Leu Gln Ala Leu 
            100                 105                 110         


Gly Ile Pro Leu His Leu Ala Tyr Asn Ser Ser Leu Val Thr Phe Gln 
        115                 120                 125             


Glu Pro Pro Gly Val Asn Thr Thr Glu Leu Pro Ser Phe Pro Lys Thr 
    130                 135                 140                 


Gln Ile Leu Glu Trp Ala Ala Glu Arg Gly Pro Ile Thr Ser Ala Ala 
145                 150                 155                 160 


Glu Leu Asn Asp Pro Gln Ser Ile Leu Leu Arg Leu Gly Gln Ala Gln 
                165                 170                 175     


Gly Ser Leu Ser Phe Cys Met Leu Glu Ala Ser Gln Asp Met Gly Arg 
            180                 185                 190         


Thr Leu Glu Trp Arg Pro Arg Thr Pro Ala Leu Val Arg Gly Cys His 
        195                 200                 205             


Leu Glu Gly Val Ala Gly His Lys Glu Ala His Ile Leu Arg Val Leu 
    210                 215                 220                 


Pro Gly His Ser Ala Gly Pro Arg Thr Val Thr Val Lys Val Glu Leu 
225                 230                 235                 240 


Ser Cys Ala Pro Gly Asp Leu Asp Ala Val Leu Ile Leu Gln Gly Pro 
                245                 250                 255     


Pro Tyr Val Ser Trp Leu Ile Asp Ala Asn His Asn Met Gln Ile Trp 
            260                 265                 270         


Thr Thr Gly Glu Tyr Ser Phe Lys Ile Phe Pro Glu Lys Asn Ile Arg 
        275                 280                 285             


Gly Phe Lys Leu Pro Asp Thr Pro Gln Gly Leu Leu Gly Glu Ala Arg 
    290                 295                 300                 


Met Leu Asn Ala Ser Ile Val Ala Ser Phe Val Glu Leu Pro Leu Ala 
305                 310                 315                 320 


Ser Ile Val Ser Leu His Ala Ser Ser Cys Gly Gly Arg Leu Gln Thr 
                325                 330                 335     


Ser Pro Ala Pro Ile Gln Thr Thr Pro Pro Lys Asp Thr Cys Ser Pro 
            340                 345                 350         


Glu Leu Leu Met Ser Leu Ile Gln Thr Lys Cys Ala Asp Asp Ala Met 
        355                 360                 365             


Thr Leu Val Leu Lys Lys Glu Leu Val Ala His Leu Lys Cys Thr Ile 
    370                 375                 380                 


Thr Gly Leu Thr Phe Trp Asp Pro Ser Cys Glu Ala Glu Asp Arg Gly 
385                 390                 395                 400 


Asp Lys Phe Val Leu Arg Ser Ala Tyr Ser Ser Cys Gly Met Gln Val 
                405                 410                 415     


Ser Ala Ser Met Ile Ser Asn Glu Ala Val Val Asn Ile Leu Ser Ser 
            420                 425                 430         


Ser Ser Pro Gln Arg Lys Lys Val His Cys Leu Asn Met Asp Ser Leu 
        435                 440                 445             


Ser Phe Gln Leu Gly Leu Tyr Leu Ser Pro His Phe Leu Gln Ala Ser 
    450                 455                 460                 


Asn Thr Ile Glu Pro Gly Gln Gln Ser Phe Val Gln Val Arg Val Ser 
465                 470                 475                 480 


Pro Ser Val Ser Glu Phe Leu Leu Gln Leu Asp Ser Cys His Leu Asp 
                485                 490                 495     


Leu Gly Pro Glu Gly Gly Thr Val Glu Leu Ile Gln Gly Arg Ala Ala 
            500                 505                 510         


Lys Gly Asn Cys Val Ser Leu Leu Ser Pro Ser Pro Glu Gly Asp Pro 
        515                 520                 525             


Arg Phe Ser Phe Leu Leu His Phe Tyr Thr Val Pro Ile Pro Lys Thr 
    530                 535                 540                 


Gly Thr Leu Ser Cys Thr Val Ala Leu Arg Pro Lys Thr Gly Ser Gln 
545                 550                 555                 560 


Asp Gln Glu Val His Arg Thr Val Phe Met Arg Leu Asn Ile Ile Ser 
                565                 570                 575     


Pro Asp Leu Ser Gly Cys Thr Ser Lys Gly Leu Val Leu Pro Ala Val 
            580                 585                 590         


Leu Gly Ile Thr Phe Gly Ala Phe Leu Ile Gly Ala Leu Leu Thr Ala 
        595                 600                 605             


Ala Leu Trp Tyr Ile Tyr Ser His Thr Arg Ser Pro Ser Lys Arg Glu 
    610                 615                 620                 


Pro Val Val Ala Val Ala Ala Pro Ala Ser Ser Glu Ser Ser Ser Thr 
625                 630                 635                 640 


Asn His Ser Ile Gly Ser Thr Gln Ser Thr Pro Cys Ser Thr Ser Ser 
                645                 650                 655     


Met Ala 
        


<210>  1279
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  1279

Met Ala Gly Val Val His Val Ser Leu Ala Ala Leu Leu Leu Leu Pro 
1               5                   10                  15      


Met Ala Pro Ala Met His Ser Asp Cys Ile Phe Lys Lys Glu Gln Ala 
            20                  25                  30          


Met Cys Leu Glu Lys Ile Gln Arg Ala Asn Glu Leu Met Gly Phe Asn 
        35                  40                  45              


Asp Ser Ser Pro Gly Cys Pro Gly Met Trp Asp Asn Ile Thr Cys Trp 
    50                  55                  60                  


Lys Pro Ala His Val Gly Glu Met Val Leu Val Ser Cys Pro Glu Leu 
65                  70                  75                  80  


Phe Arg Ile Phe Asn Pro Asp Gln Val Trp Glu Thr Glu Thr Ile Gly 
                85                  90                  95      


Glu Ser Asp Phe Gly Asp Ser Asn Ser Leu Asp Leu Ser Asp Met Gly 
            100                 105                 110         


Val Val Ser Arg Asn Cys Thr Glu Asp Gly Trp Ser Glu Pro Phe Pro 
        115                 120                 125             


His Tyr Phe Asp Ala Cys Gly Phe Asp Glu Tyr Glu Ser Glu Thr Gly 
    130                 135                 140                 


Asp Gln Asp Tyr Tyr Tyr Leu Ser Val Lys Ala Leu Tyr Thr Val Gly 
145                 150                 155                 160 


Tyr Ser Thr Ser Leu Val Thr Leu Thr Thr Ala Met Val Ile Leu Cys 
                165                 170                 175     


Arg Phe Arg Lys Leu His Cys Thr Arg Asn Phe Ile His Met Asn Leu 
            180                 185                 190         


Phe Val Ser Phe Met Leu Arg Ala Ile Ser Val Phe Ile Lys Asp Trp 
        195                 200                 205             


Ile Leu Tyr Ala Glu Gln Asp Ser Asn His Cys Phe Ile Ser Thr Val 
    210                 215                 220                 


Glu Cys Lys Ala Val Met Val Phe Phe His Tyr Cys Val Val Ser Asn 
225                 230                 235                 240 


Tyr Phe Trp Leu Phe Ile Glu Gly Leu Tyr Leu Phe Thr Leu Leu Val 
                245                 250                 255     


Glu Thr Phe Phe Pro Glu Arg Arg Tyr Phe Tyr Trp Tyr Thr Ile Ile 
            260                 265                 270         


Gly Trp Gly Thr Pro Thr Val Cys Val Thr Val Trp Ala Thr Leu Arg 
        275                 280                 285             


Leu Tyr Phe Asp Asp Thr Gly Cys Trp Asp Met Asn Asp Ser Thr Ala 
    290                 295                 300                 


Leu Trp Trp Val Ile Lys Gly Pro Val Val Gly Ser Ile Met Val Asn 
305                 310                 315                 320 


Phe Val Leu Phe Ile Gly Ile Ile Val Ile Leu Val Gln Lys Leu Gln 
                325                 330                 335     


Ser Pro Asp Met Gly Gly Asn Glu Ser Ser Ile Tyr Leu Arg Leu Ala 
            340                 345                 350         


Arg Ser Thr Leu Leu Leu Ile Pro Leu Phe Gly Ile His Tyr Thr Val 
        355                 360                 365             


Phe Ala Phe Ser Pro Glu Asn Val Ser Lys Arg Glu Arg Leu Val Phe 
    370                 375                 380                 


Glu Leu Gly Leu Gly Ser Phe Gln Gly Phe Val Val Ala Val Leu Tyr 
385                 390                 395                 400 


Cys Phe Leu Asn Gly Glu Val Gln Ala Glu Ile Lys Arg Lys Trp Arg 
                405                 410                 415     


Ser Trp Lys Val Asn Arg Tyr Phe Ala Val Asp Phe Lys His Arg His 
            420                 425                 430         


Pro Ser Leu Ala Ser Ser Gly Val Asn Gly Gly Thr Gln Leu Ser Ile 
        435                 440                 445             


Leu Ser Lys Ser Ser Ser Gln Ile Arg Met Ser Gly Leu Pro Ala Asp 
    450                 455                 460                 


Asn Leu Ala Thr 
465             


<210>  1280
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  1280

Met Gly Trp Gly Gly Gly Gly Gly Cys Thr Pro Arg Pro Pro Ile His 
1               5                   10                  15      


Gln Gln Pro Pro Glu Arg Arg Val Val Thr Val Val Phe Leu Gly Leu 
            20                  25                  30          


Leu Leu Asp Leu Leu Ala Phe Thr Leu Leu Leu Pro Leu Leu Pro Gly 
        35                  40                  45              


Leu Leu Glu Ser His Gly Arg Ala His Asp Pro Leu Tyr Gly Ser Trp 
    50                  55                  60                  


Gln Gly Gly Val Asp Trp Phe Ala Thr Ala Ile Gly Met Pro Val Glu 
65                  70                  75                  80  


Lys Arg Tyr Asn Ser Val Leu Phe Gly Gly Leu Ile Gly Ser Ala Phe 
                85                  90                  95      


Ser Val Leu Gln Phe Leu Cys Ala Pro Leu Thr Gly Ala Thr Ser Asp 
            100                 105                 110         


Cys Leu Gly Arg Arg Pro Val Met Leu Leu Cys Leu Met Gly Val Ala 
        115                 120                 125             


Thr Ser Tyr Ala Val Trp Ala Thr Ser Arg Ser Phe Ala Ala Phe Leu 
    130                 135                 140                 


Ala Ser Arg Leu Ile Gly Gly Ile Ser Lys Gly Asn Val Ser Leu Ser 
145                 150                 155                 160 


Thr Ala Ile Val Ala Asp Leu Gly Ser Pro Leu Ala Arg Ser Gln Gly 
                165                 170                 175     


Met Ala Val Ile Gly Val Ala Phe Ser Leu Gly Phe Thr Leu Gly Pro 
            180                 185                 190         


Met Leu Gly Ala Ser Leu Pro Leu Glu Met Ala Pro Trp Phe Ala Leu 
        195                 200                 205             


Leu Phe Ala Ala Ser Asp Leu Leu Phe Ile Phe Cys Phe Leu Pro Glu 
    210                 215                 220                 


Thr Leu Pro Leu Glu Lys Arg Ala Pro Ser Ile Ala Leu Gly Phe Arg 
225                 230                 235                 240 


Asp Ala Ala Asp Leu Leu Ser Pro Leu Ala Leu Leu Arg Phe Ser Ala 
                245                 250                 255     


Val Ala Arg Gly Gln Asp Pro Pro Ser Gly Asp Arg Leu Ser Ser Leu 
            260                 265                 270         


Arg Arg Leu Gly Leu Val Tyr Phe Leu Tyr Leu Phe Leu Phe Ser Gly 
        275                 280                 285             


Leu Glu Tyr Thr Leu Ser Phe Leu Thr His Gln Arg Phe Gln Phe Ser 
    290                 295                 300                 


Ser Leu Gln Gln Gly Lys Met Phe Phe Leu Ile Gly Leu Thr Met Ala 
305                 310                 315                 320 


Thr Ile Gln Gly Ala Tyr Ala Arg Arg Ile His Pro Gly Gly Glu Val 
                325                 330                 335     


Ala Ala Val Lys Arg Ala Leu Leu Leu Leu Val Pro Ala Phe Leu Leu 
            340                 345                 350         


Ile Gly Trp Gly Arg Ser Leu Pro Val Leu Gly Leu Gly Leu Leu Leu 
        355                 360                 365             


Tyr Ser Phe Ala Ala Ala Val Val Val Pro Cys Leu Ser Ser Val Val 
    370                 375                 380                 


Ala Gly Tyr Gly Ser Pro Gly Gln Lys Gly Thr Val Met Gly Thr Leu 
385                 390                 395                 400 


Arg Ser Leu Gly Ala Leu Ala Arg Ala Ala Gly Pro Leu Val Ala Ala 
                405                 410                 415     


Ser Val Tyr Trp Leu Ala Gly Ala Gln Ala Cys Phe Thr Thr Trp Ser 
            420                 425                 430         


Gly Leu Phe Leu Leu Pro Phe Phe Leu Leu Gln Lys Leu Ser Tyr Pro 
        435                 440                 445             


Ala Gln Thr Leu Lys Ala Glu 
    450                 455 


<210>  1281
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  1281

Met Asn Arg Gln Leu Val Asn Ile Leu Thr Ala Leu Phe Ala Phe Phe 
1               5                   10                  15      


Leu Glu Thr Asn His Phe Arg Thr Ala Phe Cys Lys Asp His Asp Ser 
            20                  25                  30          


Arg Ser Gly Lys Gln Pro Ser Gln Thr Leu Ser Pro Ser Asp Phe Leu 
        35                  40                  45              


Asp Lys Leu Met Gly Arg Thr Ser Gly Tyr Asp Ala Arg Ile Arg Pro 
    50                  55                  60                  


Asn Phe Lys Gly Pro Pro Val Asn Val Thr Cys Asn Ile Phe Ile Asn 
65                  70                  75                  80  


Ser Phe Gly Ser Val Thr Glu Thr Thr Met Asp Tyr Arg Val Asn Ile 
                85                  90                  95      


Phe Leu Arg Gln Gln Trp Asn Asp Ser Arg Leu Ala Tyr Ser Glu Tyr 
            100                 105                 110         


Pro Asp Asp Ser Leu Asp Leu Asp Pro Ser Met Leu Asp Ser Ile Trp 
        115                 120                 125             


Lys Pro Asp Leu Phe Phe Ala Asn Glu Lys Gly Ala Asn Phe His Asp 
    130                 135                 140                 


Val Thr Thr Asp Asn Lys Leu Leu Arg Ile Ser Lys Asn Gly Lys Val 
145                 150                 155                 160 


Leu Tyr Ser Ile Arg Leu Thr Leu Thr Leu Ser Cys Pro Met Asp Leu 
                165                 170                 175     


Lys Asn Phe Pro Met Asp Val Gln Thr Cys Thr Met Gln Leu Glu Ser 
            180                 185                 190         


Phe Gly Tyr Thr Met Asn Asp Leu Ile Phe Glu Trp Leu Ser Asp Gly 
        195                 200                 205             


Pro Val Gln Val Ala Glu Gly Leu Thr Leu Pro Gln Phe Ile Leu Lys 
    210                 215                 220                 


Glu Glu Lys Glu Leu Gly Tyr Cys Thr Lys His Tyr Asn Thr Gly Lys 
225                 230                 235                 240 


Phe Thr Cys Ile Glu Val Lys Phe His Leu Glu Arg Gln Met Gly Tyr 
                245                 250                 255     


Tyr Leu Ile Gln Met Tyr Ile Pro Ser Leu Leu Ile Val Ile Leu Ser 
            260                 265                 270         


Trp Val Ser Phe Trp Ile Asn Met Asp Ala Ala Pro Ala Arg Val Ala 
        275                 280                 285             


Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr Gln Ser Ser Gly Ser 
    290                 295                 300                 


Arg Ala Ser Leu Pro Lys Val Ser Tyr Val Lys Ala Ile Asp Ile Trp 
305                 310                 315                 320 


Met Ala Val Cys Leu Leu Phe Val Phe Ala Ala Leu Leu Glu Tyr Ala 
                325                 330                 335     


Ala Val Asn Phe Val Ser Arg Gln His Lys Glu Phe Leu Arg Leu Arg 
            340                 345                 350         


Arg Arg Gln Lys Arg Gln Asn Lys Glu Glu Asp Val Thr Arg Glu Ser 
        355                 360                 365             


Arg Phe Asn Phe Ser Gly Tyr Gly Met Gly His Cys Leu Gln Val Lys 
    370                 375                 380                 


Asp Gly Thr Ala Val Lys Ala Thr Pro Ala Asn Pro Leu Pro Gln Pro 
385                 390                 395                 400 


Pro Lys Asp Gly Asp Ala Ile Lys Lys Lys Phe Val Asp Arg Ala Lys 
                405                 410                 415     


Arg Ile Asp Thr Ile Ser Arg Ala Ala Phe Pro Leu Ala Phe Leu Ile 
            420                 425                 430         


Phe Asn Ile Phe Tyr Trp Ile Thr Tyr Lys Ile Ile Arg His Glu Asp 
        435                 440                 445             


Val His Lys Lys 
    450         


<210>  1282
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  1282

Met Asn Arg Gln Leu Val Asn Ile Leu Thr Ala Leu Phe Ala Phe Phe 
1               5                   10                  15      


Leu Glu Thr Asn His Phe Arg Thr Ala Phe Cys Lys Asp His Asp Ser 
            20                  25                  30          


Arg Ser Gly Lys Gln Pro Ser Gln Thr Leu Ser Pro Ser Asp Phe Leu 
        35                  40                  45              


Asp Lys Leu Met Gly Arg Thr Ser Gly Tyr Asp Ala Arg Ile Arg Pro 
    50                  55                  60                  


Asn Phe Lys Gly Pro Pro Val Asn Val Thr Cys Asn Ile Phe Ile Asn 
65                  70                  75                  80  


Ser Phe Gly Ser Ile Ala Glu Thr Thr Met Asp Tyr Arg Val Asn Ile 
                85                  90                  95      


Phe Leu Arg Gln Gln Trp Asn Asp Ser Arg Leu Ala Tyr Ser Glu Tyr 
            100                 105                 110         


Pro Asp Asp Ser Leu Asp Leu Asp Pro Ser Met Leu Asp Ser Ile Trp 
        115                 120                 125             


Lys Pro Asp Leu Phe Phe Ala Asn Glu Lys Gly Ala Asn Phe His Asp 
    130                 135                 140                 


Val Thr Thr Asp Asn Lys Leu Leu Arg Ile Ser Lys Asn Gly Lys Val 
145                 150                 155                 160 


Leu Tyr Ser Ile Arg Leu Thr Leu Thr Leu Ser Cys Pro Met Asp Leu 
                165                 170                 175     


Lys Asn Phe Pro Met Asp Val Gln Thr Cys Thr Met Gln Leu Glu Ser 
            180                 185                 190         


Phe Gly Tyr Thr Met Asn Asp Leu Ile Phe Glu Trp Leu Ser Asp Gly 
        195                 200                 205             


Pro Val Gln Val Ala Glu Gly Leu Thr Leu Pro Gln Phe Ile Leu Lys 
    210                 215                 220                 


Glu Glu Lys Glu Leu Gly Tyr Cys Thr Lys His Tyr Asn Thr Gly Lys 
225                 230                 235                 240 


Phe Thr Cys Ile Glu Val Lys Phe His Leu Glu Arg Gln Met Gly Tyr 
                245                 250                 255     


Tyr Leu Ile Gln Met Tyr Ile Pro Ser Leu Leu Ile Val Ile Leu Ser 
            260                 265                 270         


Trp Val Ser Phe Trp Ile Asn Met Asp Ala Ala Pro Ala Arg Val Ala 
        275                 280                 285             


Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr Gln Ser Ser Gly Ser 
    290                 295                 300                 


Arg Ala Ser Leu Pro Lys Val Ser Tyr Val Lys Ala Ile Asp Ile Trp 
305                 310                 315                 320 


Met Ala Val Cys Leu Leu Phe Val Phe Ala Ala Leu Leu Glu Tyr Ala 
                325                 330                 335     


Ala Val Asn Phe Val Ser Arg Gln His Lys Glu Phe Leu Arg Leu Arg 
            340                 345                 350         


Arg Arg Gln Lys Arg Gln Asn Lys Glu Glu Asp Val Thr Arg Glu Ser 
        355                 360                 365             


Arg Phe Asn Phe Ser Gly Tyr Gly Met Gly His Cys Leu Gln Val Lys 
    370                 375                 380                 


Asp Gly Thr Ala Val Lys Ala Thr Pro Ala Asn Pro Leu Pro Gln Pro 
385                 390                 395                 400 


Pro Lys Asp Gly Asp Ala Ile Lys Lys Lys Phe Val Asp Arg Ala Lys 
                405                 410                 415     


Arg Ile Asp Thr Ile Ser Arg Ala Ala Phe Pro Leu Ala Phe Leu Ile 
            420                 425                 430         


Phe Asn Ile Phe Tyr Trp Ile Thr Tyr Lys Ile Ile Arg His Glu Asp 
        435                 440                 445             


Val His Lys Lys 
    450         


<210>  1283
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  1283

Met Val Cys Phe Arg Leu Phe Pro Val Pro Gly Ser Gly Leu Val Leu 
1               5                   10                  15      


Val Cys Leu Val Leu Gly Ala Val Arg Ser Tyr Ala Leu Glu Leu Asn 
            20                  25                  30          


Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln Met 
        35                  40                  45              


Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr Val 
    50                  55                  60                  


Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys Gly 
65                  70                  75                  80  


Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly Phe 
                85                  90                  95      


Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile Asp 
            100                 105                 110         


Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro Asp 
        115                 120                 125             


Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile Arg 
    130                 135                 140                 


Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu Glu 
145                 150                 155                 160 


Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala Phe 
                165                 170                 175     


Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys Asp 
            180                 185                 190         


Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser Pro 
        195                 200                 205             


Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr Ser 
    210                 215                 220                 


Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu Gln 
225                 230                 235                 240 


Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn Pro 
                245                 250                 255     


Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu Leu 
            260                 265                 270         


Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala Val 
        275                 280                 285             


Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met Tyr 
    290                 295                 300                 


Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser Tyr 
305                 310                 315                 320 


Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln Thr 
                325                 330                 335     


Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg Val 
            340                 345                 350         


Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Glu Glu Cys 
        355                 360                 365             


Ser Ala Asp Ser Asp Leu Asn Phe Leu Ile Pro Val Ala Val Gly Val 
    370                 375                 380                 


Ala Leu Gly Phe Leu Ile Ile Val Val Phe Ile Ser Tyr Met Ile Gly 
385                 390                 395                 400 


Arg Arg Lys Ser Arg Thr Gly Tyr Gln Ser Val 
                405                 410     


<210>  1284
<211>  603
<212>  PRT
<213>  Homo sapiens

<400>  1284

Met Ala Val Ala Arg Lys Ile Arg Thr Leu Leu Thr Val Asn Ile Leu 
1               5                   10                  15      


Val Phe Val Gly Ile Val Leu Phe Ser Val Tyr Cys Arg Leu Gln Gly 
            20                  25                  30          


Arg Ser Gln Glu Leu Val Arg Ile Val Ser Gly Asp Arg Arg Val Arg 
        35                  40                  45              


Ser Arg His Ala Lys Val Gly Thr Leu Gly Asp Arg Glu Ala Ile Leu 
    50                  55                  60                  


Gln Arg Leu Asp His Leu Glu Glu Val Val Tyr Asn Gln Leu Asn Gly 
65                  70                  75                  80  


Leu Ala Lys Pro Ile Gly Leu Val Glu Gly Pro Gly Gly Leu Gly Gln 
                85                  90                  95      


Gly Gly Leu Ala Ala Thr Leu Arg Asp Asp Gly Gln Glu Ala Glu Gly 
            100                 105                 110         


Lys Tyr Glu Glu Tyr Gly Tyr Asn Ala Gln Leu Ser Asp Arg Ile Ser 
        115                 120                 125             


Leu Asp Arg Ser Ile Pro Asp Tyr Arg Pro Arg Lys Cys Arg Gln Met 
    130                 135                 140                 


Ser Tyr Ala Gln Asp Leu Pro Gln Val Ser Val Val Phe Ile Phe Val 
145                 150                 155                 160 


Asn Glu Ala Leu Ser Val Ile Leu Arg Ser Val His Ser Val Val Asn 
                165                 170                 175     


His Thr Pro Ser Gln Leu Leu Lys Glu Val Ile Leu Val Asp Asp Asn 
            180                 185                 190         


Ser Asp Asn Val Glu Leu Lys Phe Asn Leu Asp Gln Tyr Val Asn Lys 
        195                 200                 205             


Arg Tyr Pro Gly Leu Val Lys Ile Val Arg Asn Ser Arg Arg Glu Gly 
    210                 215                 220                 


Leu Ile Arg Ala Arg Leu Gln Gly Trp Lys Ala Ala Thr Ala Pro Val 
225                 230                 235                 240 


Val Gly Phe Phe Asp Ala His Val Glu Phe Asn Thr Gly Trp Ala Glu 
                245                 250                 255     


Pro Ala Leu Ser Arg Ile Arg Glu Asp Arg Arg Arg Ile Val Leu Pro 
            260                 265                 270         


Ala Ile Asp Asn Ile Lys Tyr Ser Thr Phe Glu Val Gln Gln Tyr Ala 
        275                 280                 285             


Asn Ala Ala His Gly Tyr Asn Trp Gly Leu Trp Cys Met Tyr Ile Ile 
    290                 295                 300                 


Pro Pro Gln Asp Trp Leu Asp Arg Gly Asp Glu Ser Ala Pro Ile Arg 
305                 310                 315                 320 


Thr Pro Ala Met Ile Gly Cys Ser Phe Val Val Asp Arg Glu Tyr Phe 
                325                 330                 335     


Gly Asp Ile Gly Leu Leu Asp Pro Gly Met Glu Val Tyr Gly Gly Glu 
            340                 345                 350         


Asn Val Glu Leu Gly Met Arg Val Trp Gln Cys Gly Gly Ser Met Glu 
        355                 360                 365             


Val Leu Pro Cys Ser Arg Val Ala His Ile Glu Arg Thr Arg Lys Pro 
    370                 375                 380                 


Tyr Asn Asn Asp Ile Asp Tyr Tyr Ala Lys Arg Asn Ala Leu Arg Ala 
385                 390                 395                 400 


Ala Glu Val Trp Met Asp Asp Phe Lys Ser His Val Tyr Met Ala Trp 
                405                 410                 415     


Asn Ile Pro Met Ser Asn Pro Gly Val Asp Phe Gly Asp Val Ser Glu 
            420                 425                 430         


Arg Leu Ala Leu Arg Gln Arg Leu Lys Cys Arg Ser Phe Lys Trp Tyr 
        435                 440                 445             


Leu Glu Asn Val Tyr Pro Glu Met Arg Val Tyr Asn Asn Thr Leu Thr 
    450                 455                 460                 


Tyr Gly Glu Val Arg Asn Ser Lys Ala Ser Ala Tyr Cys Leu Asp Gln 
465                 470                 475                 480 


Gly Ala Glu Asp Gly Asp Arg Ala Ile Leu Tyr Pro Cys His Gly Met 
                485                 490                 495     


Ser Ser Gln Leu Val Arg Tyr Ser Ala Asp Gly Leu Leu Gln Leu Gly 
            500                 505                 510         


Pro Leu Gly Ser Thr Ala Phe Leu Pro Asp Ser Lys Cys Leu Val Asp 
        515                 520                 525             


Asp Gly Thr Gly Arg Met Pro Thr Leu Lys Lys Cys Glu Asp Val Ala 
    530                 535                 540                 


Arg Pro Thr Gln Arg Leu Trp Asp Phe Thr Gln Ser Gly Pro Ile Val 
545                 550                 555                 560 


Ser Arg Ala Thr Gly Arg Cys Leu Glu Val Glu Met Ser Lys Asp Ala 
                565                 570                 575     


Asn Phe Gly Leu Arg Leu Val Val Gln Arg Cys Ser Gly Gln Lys Trp 
            580                 585                 590         


Met Ile Arg Asn Trp Ile Lys His Ala Arg His 
        595                 600             


<210>  1285
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  1285

Met Gln Pro Pro Pro Ser Leu Cys Gly Arg Ala Leu Val Ala Leu Val 
1               5                   10                  15      


Leu Ala Cys Gly Leu Ser Arg Ile Trp Gly Glu Glu Arg Gly Phe Pro 
            20                  25                  30          


Pro Asp Arg Ala Thr Pro Leu Leu Gln Thr Ala Glu Ile Met Thr Pro 
        35                  40                  45              


Pro Thr Lys Thr Leu Trp Pro Lys Gly Ser Asn Ala Ser Leu Ala Arg 
    50                  55                  60                  


Ser Leu Ala Pro Ala Glu Val Pro Lys Gly Asp Arg Thr Ala Gly Ser 
65                  70                  75                  80  


Pro Pro Arg Thr Ile Ser Pro Pro Pro Cys Gln Gly Pro Ile Glu Ile 
                85                  90                  95      


Lys Glu Thr Phe Lys Tyr Ile Asn Thr Val Val Ser Cys Leu Val Phe 
            100                 105                 110         


Val Leu Gly Ile Ile Gly Asn Ser Thr Leu Leu Arg Ile Ile Tyr Lys 
        115                 120                 125             


Asn Lys Cys Met Arg Asn Gly Pro Asn Ile Leu Ile Ala Ser Leu Ala 
    130                 135                 140                 


Leu Gly Asp Leu Leu His Ile Val Ile Asp Ile Pro Ile Asn Val Tyr 
145                 150                 155                 160 


Lys Leu Leu Ala Glu Asp Trp Pro Phe Gly Ala Glu Met Cys Lys Leu 
                165                 170                 175     


Val Pro Phe Ile Gln Lys Ala Ser Val Gly Ile Thr Val Leu Ser Leu 
            180                 185                 190         


Cys Ala Leu Ser Ile Asp Arg Tyr Arg Ala Val Ala Ser Trp Ser Arg 
        195                 200                 205             


Ile Lys Gly Ile Gly Val Pro Lys Trp Thr Ala Val Glu Ile Val Leu 
    210                 215                 220                 


Ile Trp Val Val Ser Val Val Leu Ala Val Pro Glu Ala Ile Gly Phe 
225                 230                 235                 240 


Asp Ile Ile Thr Met Asp Tyr Lys Gly Ser Tyr Leu Arg Ile Cys Leu 
                245                 250                 255     


Leu His Pro Val Gln Lys Thr Ala Phe Met Gln Phe Tyr Lys Thr Ala 
            260                 265                 270         


Lys Asp Trp Trp Leu Phe Ser Phe Tyr Phe Cys Leu Pro Leu Ala Ile 
        275                 280                 285             


Thr Ala Phe Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Arg Lys Lys 
    290                 295                 300                 


Ser Gly Met Gln Ile Ala Leu Asn Asp His Leu Lys Gln Arg Arg Glu 
305                 310                 315                 320 


Val Ala Lys Thr Val Phe Cys Leu Val Leu Val Phe Ala Leu Cys Trp 
                325                 330                 335     


Leu Pro Leu His Leu Ser Arg Ile Leu Lys Leu Thr Leu Tyr Asn Gln 
            340                 345                 350         


Asn Asp Pro Asn Arg Cys Glu Leu Leu Ser Phe Leu Leu Val Leu Asp 
        355                 360                 365             


Tyr Ile Gly Ile Asn Met Ala Ser Leu Asn Ser Cys Ile Asn Pro Ile 
    370                 375                 380                 


Ala Leu Tyr Leu Val Ser Lys Arg Phe Lys Asn Cys Phe Lys Ser Cys 
385                 390                 395                 400 


Leu Cys Cys Trp Cys Gln Ser Phe Glu Glu Lys Gln Ser Leu Glu Glu 
                405                 410                 415     


Lys Gln Ser Cys Leu Lys Phe Lys Ala Asn Asp His Gly Tyr Asp Asn 
            420                 425                 430         


Phe Arg Ser Ser Asn Lys Tyr Ser Ser Ser 
        435                 440         


<210>  1286
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  1286

Met Leu Pro Arg Trp Glu Leu Ala Leu Tyr Leu Leu Ala Ser Leu Gly 
1               5                   10                  15      


Phe His Phe Tyr Ser Phe Tyr Glu Val Tyr Lys Val Ser Arg Glu His 
            20                  25                  30          


Glu Glu Glu Leu Asp Gln Glu Phe Glu Leu Glu Thr Asp Thr Leu Phe 
        35                  40                  45              


Gly Gly Leu Lys Lys Asp Ala Thr Asp Phe Glu Trp Ser Phe Trp Met 
    50                  55                  60                  


Glu Trp Gly Lys Gln Trp Leu Val Trp Leu Leu Leu Gly His Met Val 
65                  70                  75                  80  


Val Ser Gln Met Ala Thr Leu Leu Ala Arg Lys His Arg Pro Trp Ile 
                85                  90                  95      


Leu Met Leu Tyr Gly Met Trp Ala Cys Trp Cys Val Leu Gly Thr Pro 
            100                 105                 110         


Gly Val Ala Met Val Leu Leu His Thr Thr Ile Ser Phe Cys Val Ala 
        115                 120                 125             


Gln Phe Arg Ser Gln Leu Leu Thr Trp Leu Cys Ser Leu Leu Leu Leu 
    130                 135                 140                 


Ser Thr Leu Arg Leu Gln Gly Val Glu Glu Val Lys Arg Arg Trp Tyr 
145                 150                 155                 160 


Lys Thr Glu Asn Glu Tyr Tyr Leu Leu Gln Phe Thr Leu Thr Val Arg 
                165                 170                 175     


Cys Leu Tyr Tyr Thr Ser Phe Ser Leu Glu Leu Cys Trp Gln Gln Leu 
            180                 185                 190         


Pro Ala Ala Ser Thr Ser Tyr Ser Phe Pro Trp Met Leu Ala Tyr Val 
        195                 200                 205             


Phe Tyr Tyr Pro Val Leu His Asn Gly Pro Ile Leu Ser Phe Ser Glu 
    210                 215                 220                 


Phe Ile Lys Gln Met Gln Gln Gln Glu His Asp Ser Leu Lys Ala Ser 
225                 230                 235                 240 


Leu Cys Val Leu Ala Leu Gly Leu Gly Arg Leu Leu Cys Trp Trp Trp 
                245                 250                 255     


Leu Ala Glu Leu Met Ala His Leu Met Tyr Met His Ala Ile Tyr Ser 
            260                 265                 270         


Ser Ile Pro Leu Leu Glu Thr Val Ser Cys Trp Thr Leu Gly Gly Leu 
        275                 280                 285             


Ala Leu Ala Gln Val Leu Phe Phe Tyr Val Lys Tyr Leu Val Leu Phe 
    290                 295                 300                 


Gly Val Pro Ala Leu Leu Met Arg Leu Asp Gly Leu Thr Pro Pro Ala 
305                 310                 315                 320 


Leu Pro Arg Cys Val Ser Thr Met Phe Ser Phe Thr Gly Met Trp Arg 
                325                 330                 335     


Tyr Phe Asp Val Gly Leu His Asn Phe Leu Ile Arg Tyr Val Tyr Ile 
            340                 345                 350         


Pro Val Gly Gly Ser Gln His Gly Leu Leu Gly Thr Leu Phe Ser Thr 
        355                 360                 365             


Ala Met Thr Phe Ala Phe Val Ser Tyr Trp His Gly Gly Tyr Asp Tyr 
    370                 375                 380                 


Leu Trp Cys Trp Ala Ala Leu Asn Trp Leu Gly Val Thr Val Glu Asn 
385                 390                 395                 400 


Gly Val Arg Arg Leu Val Glu Thr Pro Cys Ile Gln Asp Ser Leu Ala 
                405                 410                 415     


Arg Tyr Phe Ser Pro Gln Ala Arg Arg Arg Phe His Ala Ala Leu Ala 
            420                 425                 430         


Ser Cys Ser Thr Ser Met Leu Ile Leu Ser Asn Leu Val Phe Leu Gly 
        435                 440                 445             


Gly Asn Glu Val Gly Lys Thr Tyr Trp Asn Arg Ile Phe Ile Gln Gly 
    450                 455                 460                 


Trp Pro Trp Val Thr Leu Ser Val Leu Gly Phe Leu Tyr Cys Tyr Ser 
465                 470                 475                 480 


His Val Gly Ile Ala Trp Ala Gln Thr Tyr Ala Thr Asp 
                485                 490             


<210>  1287
<211>  806
<212>  PRT
<213>  Homo sapiens

<400>  1287

Met Ala Pro Ala Gly Cys Cys Cys Cys Cys Cys Phe Trp Gly Gly Ala 
1               5                   10                  15      


Val Ala Ala Ala Gly Ala Ala Arg Arg Val Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Gly Val Leu Ser Ala Gly Leu Arg Pro Gly Ala Leu Ala Thr Glu His 
        35                  40                  45              


Tyr Ser Pro Leu Ser Leu Leu Lys Gln Glu Leu Gln His Arg Gln Gln 
    50                  55                  60                  


Gln Glu Ala Pro Ala Gly Gly Gly Gly Cys Ser Pro Gln Ser Gly Asp 
65                  70                  75                  80  


Trp Gly Asp Gln Tyr Ser Ala Glu Cys Gly Glu Ser Ser Phe Leu Asn 
                85                  90                  95      


Phe His Asp Ser Asp Cys Glu Pro Lys Gly Ser Ser Pro Cys Asp Ser 
            100                 105                 110         


Leu Leu Ser Leu Asn Thr Glu Lys Ile Leu Ser Gln Ala Lys Ser Ile 
        115                 120                 125             


Ala Glu Gln Lys Arg Phe Pro Phe Ala Thr Asp Asn Asp Ser Thr Asn 
    130                 135                 140                 


Glu Glu Leu Ala Ile Ala Tyr Val Leu Ile Gly Ser Gly Leu Tyr Asp 
145                 150                 155                 160 


Glu Ala Ile Arg His Phe Ser Thr Met Leu Gln Ile Leu Ser Pro Leu 
                165                 170                 175     


Gly Arg Ile Asn Glu Ala Val Asn Asp Leu Thr Lys Ala Ile Gln Leu 
            180                 185                 190         


Gln Pro Ser Ala Arg Leu Tyr Arg His Arg Gly Thr Leu Tyr Phe Ile 
        195                 200                 205             


Ser Glu Asp Tyr Ala Thr Ala His Glu Asp Phe Gln Gln Ser Leu Glu 
    210                 215                 220                 


Leu Asn Lys Asn Gln Pro Ile Ala Met Leu Tyr Lys Gly Leu Thr Phe 
225                 230                 235                 240 


Phe His Arg Gly Leu Leu Lys Glu Ala Ile Glu Ser Phe Lys Glu Ala 
                245                 250                 255     


Leu Lys Gln Lys Val Asp Phe Ile Asp Ala Tyr Lys Ser Leu Gly Gln 
            260                 265                 270         


Ala Tyr Arg Glu Leu Gly Asn Phe Glu Ala Ala Thr Glu Ser Phe Gln 
        275                 280                 285             


Lys Ala Leu Leu Leu Asn Gln Asn His Val Gln Thr Leu Gln Leu Arg 
    290                 295                 300                 


Gly Met Met Leu Tyr His His Gly Ser Leu Gln Glu Ala Leu Lys Asn 
305                 310                 315                 320 


Phe Lys Arg Cys Leu Gln Leu Glu Pro Tyr Asn Glu Val Cys Gln Tyr 
                325                 330                 335     


Met Lys Gly Leu Ser His Val Ala Met Gly Gln Phe Tyr Glu Gly Ile 
            340                 345                 350         


Lys Ala Gln Thr Lys Val Met Leu Asn Asp Pro Leu Pro Gly Gln Lys 
        355                 360                 365             


Ala Ser Pro Glu Tyr Leu Lys Val Lys Tyr Leu Arg Glu Tyr Ser Arg 
    370                 375                 380                 


Tyr Leu His Ala His Leu Asp Thr Pro Leu Thr Glu Tyr Asn Ile Asp 
385                 390                 395                 400 


Val Asp Leu Pro Gly Ser Phe Lys Asp His Trp Ala Lys Asn Leu Pro 
                405                 410                 415     


Phe Leu Ile Glu Asp Tyr Glu Glu Gln Pro Gly Leu Gln Pro His Ile 
            420                 425                 430         


Lys Asp Val Leu His Gln Asn Phe Glu Ser Tyr Lys Pro Glu Val Gln 
        435                 440                 445             


Glu Leu Ile Cys Val Ala Asp Arg Leu Gly Ser Leu Met Gln Tyr Glu 
    450                 455                 460                 


Thr Pro Gly Phe Leu Pro Asn Lys Arg Ile His Arg Ala Met Gly Leu 
465                 470                 475                 480 


Ala Ala Leu Glu Val Met Gln Ala Val Gln Arg Thr Trp Thr Asn Ser 
                485                 490                 495     


Lys Val Arg Met Asn Gly Lys Thr Arg Leu Met Gln Trp Arg Asp Met 
            500                 505                 510         


Phe Asp Ile Ala Val Lys Trp Arg Arg Ile Ala Asp Pro Asp Gln Pro 
        515                 520                 525             


Val Leu Trp Leu Asp Gln Met Pro Ala Arg Ser Leu Ser Arg Gly Phe 
    530                 535                 540                 


Asn Asn His Ile Asn Leu Ile Arg Gly Gln Val Ile Asn Met Arg Tyr 
545                 550                 555                 560 


Leu Glu Tyr Phe Glu Lys Ile Leu His Phe Ile Lys Asp Arg Ile Leu 
                565                 570                 575     


Val Tyr His Gly Ala Asn Asn Pro Lys Gly Leu Leu Glu Val Arg Glu 
            580                 585                 590         


Ala Leu Glu Lys Val His Lys Val Glu Asp Leu Leu Pro Ile Met Lys 
        595                 600                 605             


Phe Asn Thr Lys Thr Lys Asp Gly Phe Thr Val Asn Thr Lys Val Pro 
    610                 615                 620                 


Ser Leu Lys Asp Gln Gly Lys Glu Tyr Asp Gly Phe Thr Ile Thr Ile 
625                 630                 635                 640 


Thr Gly Asp Lys Val Gly Asn Ile Leu Phe Ser Val Glu Thr Gln Thr 
                645                 650                 655     


Thr Glu Glu Arg Thr Gln Leu Tyr His Ala Glu Ile Asp Ala Leu Tyr 
            660                 665                 670         


Lys Asp Leu Thr Ala Lys Gly Lys Val Leu Ile Leu Ser Ser Glu Phe 
        675                 680                 685             


Gly Glu Ala Asp Ala Val Cys Asn Leu Ile Leu Ser Leu Val Tyr Tyr 
    690                 695                 700                 


Phe Tyr Asn Leu Met Pro Leu Ser Arg Gly Ser Ser Val Ile Ala Tyr 
705                 710                 715                 720 


Ser Val Ile Val Gly Ala Leu Met Ala Ser Gly Lys Glu Val Ala Gly 
                725                 730                 735     


Lys Ile Pro Lys Gly Lys Leu Val Asp Phe Glu Ala Met Thr Ala Pro 
            740                 745                 750         


Gly Ser Glu Ala Phe Ser Lys Val Ala Lys Ser Trp Met Asn Leu Lys 
        755                 760                 765             


Ser Ile Ser Pro Ser Tyr Lys Thr Leu Pro Ser Val Ser Glu Thr Phe 
    770                 775                 780                 


Pro Thr Leu Arg Ser Met Ile Glu Val Leu Asn Thr Asp Ser Ser Pro 
785                 790                 795                 800 


Arg Cys Leu Lys Lys Leu 
                805     


<210>  1288
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  1288

Met Arg Gly Leu His Pro Trp His Val Leu Arg Arg Pro Leu Gly Pro 
1               5                   10                  15      


Gln Ala His Ala Asn Asp Pro Glu Cys Gly Gln Arg Pro Val Pro Ala 
            20                  25                  30          


Leu Ser His His Gly Ser Gln Arg Val Val Leu Leu Gln Thr Ala Thr 
        35                  40                  45              


Leu Leu Gly Val Leu Leu Leu Gly Tyr Gly Tyr Phe Trp Leu Leu Val 
    50                  55                  60                  


Pro Asn Pro Glu Ala Arg Leu Gln Gln Leu Gly Leu Phe Cys Ser Val 
65                  70                  75                  80  


Phe Thr Ile Ser Met Tyr Leu Ser Pro Leu Ala Asp Leu Ala Lys Val 
                85                  90                  95      


Ile Gln Thr Lys Ser Thr Gln Cys Leu Ser Tyr Pro Leu Thr Ile Ala 
            100                 105                 110         


Thr Leu Leu Thr Ser Ala Ser Trp Cys Leu Tyr Gly Phe Arg Leu Arg 
        115                 120                 125             


Asp Pro Tyr Ile Met Val Ser Asn Phe Pro Gly Ile Val Thr Ser Phe 
    130                 135                 140                 


Ile Arg Phe Trp Leu Phe Trp Lys Tyr Pro Gln Glu Gln Asp Arg Asn 
145                 150                 155                 160 


Tyr Trp Leu Leu Gln Thr 
                165     


<210>  1289
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  1289

Met Glu Ala Gly Gly Phe Leu Asp Ser Leu Ile Tyr Gly Ala Cys Val 
1               5                   10                  15      


Val Phe Thr Leu Gly Met Phe Ser Ala Gly Leu Ser Asp Leu Arg His 
            20                  25                  30          


Met Arg Met Thr Arg Ser Val Asp Asn Val Gln Phe Leu Pro Phe Leu 
        35                  40                  45              


Thr Thr Glu Val Asn Asn Leu Gly Trp Leu Ser Tyr Gly Ala Leu Lys 
    50                  55                  60                  


Gly Asp Gly Ile Leu Ile Val Val Asn Thr Val Gly Ala Ala Leu Gln 
65                  70                  75                  80  


Thr Leu Tyr Ile Leu Ala Tyr Leu His Tyr Cys Pro Arg Lys Ala Lys 
                85                  90                  95      


Val Ile Gln Thr Lys Ser Thr Gln Cys Leu Ser Tyr Pro Leu Thr Ile 
            100                 105                 110         


Ala Thr Leu Leu Thr Ser Ala Ser Trp Cys Leu Tyr Gly Phe Arg Leu 
        115                 120                 125             


Arg Asp Pro Tyr Ile Met Val Ser Asn Phe Pro Gly Ile Val Thr Ser 
    130                 135                 140                 


Phe Ile Arg Phe Trp Leu Phe Trp Lys Tyr Pro Gln Glu Gln Asp Arg 
145                 150                 155                 160 


Asn Tyr Trp Leu Leu Gln Thr 
                165         


<210>  1290
<211>  614
<212>  PRT
<213>  Homo sapiens

<400>  1290

Met Asp Gly Lys Val Ala Val Gln Glu Cys Gly Pro Pro Ala Val Ser 
1               5                   10                  15      


Trp Val Pro Glu Glu Gly Glu Lys Leu Asp Gln Glu Asp Glu Asp Gln 
            20                  25                  30          


Val Lys Asp Arg Gly Gln Trp Thr Asn Lys Met Glu Phe Val Leu Ser 
        35                  40                  45              


Val Ala Gly Glu Ile Ile Gly Leu Gly Asn Val Trp Arg Phe Pro Tyr 
    50                  55                  60                  


Leu Cys Tyr Lys Asn Gly Gly Gly Ala Phe Phe Ile Pro Tyr Phe Ile 
65                  70                  75                  80  


Phe Phe Phe Val Cys Gly Ile Pro Val Phe Phe Leu Glu Val Ala Leu 
                85                  90                  95      


Gly Gln Tyr Thr Ser Gln Gly Ser Val Thr Ala Trp Arg Lys Ile Cys 
            100                 105                 110         


Pro Leu Phe Gln Gly Ile Gly Leu Ala Ser Val Val Ile Glu Ser Tyr 
        115                 120                 125             


Leu Asn Val Tyr Tyr Ile Ile Ile Leu Ala Trp Ala Leu Phe Tyr Leu 
    130                 135                 140                 


Phe Ser Ser Phe Thr Ser Glu Leu Pro Trp Thr Thr Cys Asn Asn Phe 
145                 150                 155                 160 


Trp Asn Thr Glu His Cys Thr Asp Phe Leu Asn His Ser Gly Ala Gly 
                165                 170                 175     


Thr Val Thr Pro Phe Glu Asn Phe Thr Ser Pro Val Met Glu Phe Trp 
            180                 185                 190         


Glu Arg Arg Val Leu Gly Ile Thr Ser Gly Ile His Asp Leu Gly Ser 
        195                 200                 205             


Leu Arg Trp Glu Leu Ala Leu Cys Leu Leu Leu Ala Trp Val Ile Cys 
    210                 215                 220                 


Tyr Phe Cys Ile Trp Lys Gly Val Lys Ser Thr Gly Lys Val Val Tyr 
225                 230                 235                 240 


Phe Thr Ala Thr Phe Pro Tyr Leu Met Leu Val Ile Leu Leu Ile Arg 
                245                 250                 255     


Gly Val Thr Leu Pro Gly Ala Tyr Gln Gly Ile Ile Tyr Tyr Leu Lys 
            260                 265                 270         


Pro Asp Leu Phe Arg Leu Lys Asp Pro Gln Val Trp Met Asp Ala Gly 
        275                 280                 285             


Thr Gln Ile Phe Phe Ser Phe Ala Ile Cys Gln Gly Cys Leu Thr Ala 
    290                 295                 300                 


Leu Gly Ser Tyr Asn Lys Tyr His Asn Asn Cys Tyr Lys Asp Cys Ile 
305                 310                 315                 320 


Ala Leu Cys Phe Leu Asn Ser Ala Thr Ser Phe Val Ala Gly Phe Val 
                325                 330                 335     


Val Phe Ser Ile Leu Gly Phe Met Ser Gln Glu Gln Gly Val Pro Ile 
            340                 345                 350         


Ser Glu Val Ala Glu Ser Gly Pro Gly Leu Ala Phe Ile Ala Phe Pro 
        355                 360                 365             


Lys Ala Val Thr Met Met Pro Leu Ser Gln Leu Trp Ser Cys Leu Phe 
    370                 375                 380                 


Phe Ile Met Leu Ile Phe Leu Gly Leu Asp Ser Gln Phe Val Cys Val 
385                 390                 395                 400 


Glu Cys Leu Val Thr Ala Ser Ile Asp Met Phe Pro Arg Gln Leu Arg 
                405                 410                 415     


Lys Ser Gly Arg Arg Glu Leu Leu Ile Leu Thr Ile Ala Val Met Cys 
            420                 425                 430         


Tyr Leu Ile Gly Leu Phe Leu Val Thr Glu Gly Gly Met Tyr Ile Phe 
        435                 440                 445             


Gln Leu Phe Asp Tyr Tyr Ala Ser Ser Gly Ile Cys Leu Leu Phe Leu 
    450                 455                 460                 


Ser Leu Phe Glu Val Val Cys Ile Ser Trp Val Tyr Gly Ala Asp Arg 
465                 470                 475                 480 


Phe Tyr Asp Asn Ile Glu Asp Met Ile Gly Tyr Arg Pro Trp Pro Leu 
                485                 490                 495     


Val Lys Ile Ser Trp Leu Phe Leu Thr Pro Gly Leu Cys Leu Ala Thr 
            500                 505                 510         


Phe Leu Phe Ser Leu Ser Lys Tyr Thr Pro Leu Lys Tyr Asn Asn Val 
        515                 520                 525             


Tyr Val Tyr Pro Pro Trp Gly Tyr Ser Ile Gly Trp Phe Leu Ala Leu 
    530                 535                 540                 


Ser Ser Met Val Cys Val Pro Leu Phe Val Val Ile Thr Leu Leu Lys 
545                 550                 555                 560 


Thr Arg Gly Pro Phe Arg Lys Arg Leu Arg Gln Leu Ile Thr Pro Asp 
                565                 570                 575     


Ser Ser Leu Pro Gln Pro Lys Gln His Pro Cys Leu Asp Gly Ser Ala 
            580                 585                 590         


Gly Arg Asn Phe Gly Pro Ser Pro Thr Arg Glu Gly Leu Ile Ala Gly 
        595                 600                 605             


Glu Lys Glu Thr His Leu 
    610                 


<210>  1291
<211>  614
<212>  PRT
<213>  Homo sapiens

<400>  1291

Met Asp Gly Lys Val Ala Val Gln Glu Cys Gly Pro Pro Ala Val Ser 
1               5                   10                  15      


Trp Val Pro Glu Glu Gly Glu Lys Leu Asp Gln Glu Asp Glu Asp Gln 
            20                  25                  30          


Val Lys Asp Arg Gly Gln Trp Thr Asn Lys Met Glu Phe Val Leu Ser 
        35                  40                  45              


Val Ala Gly Glu Ile Ile Gly Leu Gly Asn Val Trp Arg Phe Pro Tyr 
    50                  55                  60                  


Leu Cys Tyr Lys Asn Gly Gly Gly Ala Phe Phe Ile Pro Tyr Phe Ile 
65                  70                  75                  80  


Phe Phe Phe Val Cys Gly Ile Pro Val Phe Phe Leu Glu Val Ala Leu 
                85                  90                  95      


Gly Gln Tyr Thr Ser Gln Gly Ser Val Thr Ala Trp Arg Lys Ile Cys 
            100                 105                 110         


Pro Leu Phe Gln Gly Ile Gly Leu Ala Ser Val Val Ile Glu Ser Tyr 
        115                 120                 125             


Leu Asn Val Tyr Tyr Ile Ile Ile Leu Ala Trp Ala Leu Phe Tyr Leu 
    130                 135                 140                 


Phe Ser Ser Phe Thr Ser Glu Leu Pro Trp Thr Thr Cys Asn Asn Phe 
145                 150                 155                 160 


Trp Asn Thr Glu His Cys Thr Asp Phe Leu Asn His Ser Gly Ala Gly 
                165                 170                 175     


Thr Val Thr Pro Phe Glu Asn Phe Thr Ser Pro Val Met Glu Phe Trp 
            180                 185                 190         


Glu Arg Arg Val Leu Gly Ile Thr Ser Gly Ile His Asp Leu Gly Ser 
        195                 200                 205             


Leu Arg Trp Glu Leu Ala Leu Cys Leu Leu Leu Ala Trp Val Ile Cys 
    210                 215                 220                 


Tyr Phe Cys Ile Trp Lys Gly Val Lys Ser Thr Gly Lys Val Val Tyr 
225                 230                 235                 240 


Phe Thr Ala Thr Phe Pro Tyr Leu Met Leu Val Ile Leu Leu Ile Arg 
                245                 250                 255     


Gly Val Thr Leu Pro Gly Ala Tyr Gln Gly Ile Ile Tyr Tyr Leu Lys 
            260                 265                 270         


Pro Asp Leu Phe Arg Leu Lys Asp Pro Gln Val Trp Met Asp Ala Gly 
        275                 280                 285             


Thr Gln Ile Phe Phe Ser Phe Ala Ile Cys Gln Gly Cys Leu Thr Ala 
    290                 295                 300                 


Leu Gly Ser Tyr Asn Lys Tyr His Asn Asn Cys Tyr Lys Asp Cys Ile 
305                 310                 315                 320 


Ala Leu Cys Phe Leu Asn Ser Ala Thr Ser Phe Val Ala Gly Phe Val 
                325                 330                 335     


Val Phe Ser Ile Leu Gly Phe Met Ser Gln Glu Gln Gly Val Pro Ile 
            340                 345                 350         


Ser Glu Val Ala Glu Ser Gly Pro Gly Leu Ala Phe Ile Ala Phe Pro 
        355                 360                 365             


Lys Ala Val Thr Met Met Pro Leu Ser Gln Leu Trp Ser Cys Leu Phe 
    370                 375                 380                 


Phe Ile Met Leu Ile Phe Leu Gly Leu Asp Ser Gln Phe Val Cys Val 
385                 390                 395                 400 


Glu Cys Leu Val Thr Ala Ser Ile Asp Met Phe Pro Arg Gln Leu Arg 
                405                 410                 415     


Lys Ser Gly Arg Arg Glu Leu Leu Ile Leu Thr Ile Ala Val Met Cys 
            420                 425                 430         


Tyr Leu Ile Gly Leu Phe Leu Val Thr Glu Gly Gly Met Tyr Ile Phe 
        435                 440                 445             


Gln Leu Phe Asp Tyr Tyr Ala Ser Ser Gly Ile Cys Leu Leu Phe Leu 
    450                 455                 460                 


Ser Leu Phe Glu Val Val Cys Ile Ser Trp Val Tyr Gly Ala Asp Arg 
465                 470                 475                 480 


Phe Tyr Asp Asn Ile Glu Asp Met Ile Gly Tyr Arg Pro Trp Pro Leu 
                485                 490                 495     


Val Lys Ile Ser Trp Leu Phe Leu Thr Pro Gly Leu Cys Leu Ala Thr 
            500                 505                 510         


Phe Leu Phe Ser Leu Ser Lys Tyr Thr Pro Leu Lys Tyr Asn Asn Val 
        515                 520                 525             


Tyr Val Tyr Pro Pro Trp Gly Tyr Ser Ile Gly Trp Phe Leu Ala Leu 
    530                 535                 540                 


Ser Ser Met Val Cys Val Pro Leu Phe Val Val Ile Thr Leu Leu Lys 
545                 550                 555                 560 


Thr Arg Gly Pro Phe Arg Lys Arg Leu Arg Gln Leu Ile Thr Pro Asp 
                565                 570                 575     


Ser Ser Leu Pro Gln Pro Lys Gln His Pro Cys Leu Asp Gly Ser Ala 
            580                 585                 590         


Gly Arg Asn Phe Gly Pro Ser Pro Thr Arg Glu Gly Leu Ile Ala Gly 
        595                 600                 605             


Glu Lys Glu Thr His Leu 
    610                 


<210>  1292
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  1292

Met Ala Arg Gly Ala Ala Leu Ala Leu Leu Leu Phe Gly Leu Leu Gly 
1               5                   10                  15      


Val Leu Val Ala Ala Pro Asp Gly Gly Phe Asp Leu Ser Asp Ala Leu 
            20                  25                  30          


Pro Gly Asp Asp Phe Asp Leu Gly Asp Ala Val Val Asp Gly Glu Asn 
        35                  40                  45              


Asp Asp Pro Arg Pro Pro Asn Pro Pro Lys Pro Met Pro Asn Pro Asn 
    50                  55                  60                  


Pro Asn His Pro Ser Ser Ser Gly Ser Phe Ser Asp Ala Asp Leu Ala 
65                  70                  75                  80  


Asp Gly Val Ser Gly Gly Glu Gly Lys Gly Gly Ser Asp Gly Gly Gly 
                85                  90                  95      


Ser His Arg Lys Glu Gly Glu Glu Ala Asp Ala Pro Gly Val Ile Pro 
            100                 105                 110         


Gly Ile Val Gly Ala Val Val Val Ala Val Ala Gly Ala Ile Ser Ser 
        115                 120                 125             


Phe Ile Ala Tyr Gln Lys Lys Lys Leu Cys Phe Lys Glu Asn Ala Glu 
    130                 135                 140                 


Gln Gly Glu Val Asp Met Glu Ser His Arg Asn Ala Asn Ala Glu Pro 
145                 150                 155                 160 


Ala Val Gln Arg Thr Leu Leu Glu Lys 
                165                 


<210>  1293
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  1293

Met Ala Ser Ser Gly Tyr Val Leu Gln Ala Glu Leu Ser Pro Ser Thr 
1               5                   10                  15      


Glu Asn Ser Ser Gln Leu Asp Phe Glu Asp Val Trp Asn Ser Ser Tyr 
            20                  25                  30          


Gly Val Asn Asp Ser Phe Pro Asp Gly Asp Tyr Gly Ala Asn Leu Glu 
        35                  40                  45              


Ala Ala Ala Pro Cys His Ser Cys Asn Leu Leu Asp Asp Ser Ala Leu 
    50                  55                  60                  


Pro Phe Phe Ile Leu Thr Ser Val Leu Gly Ile Leu Ala Ser Ser Thr 
65                  70                  75                  80  


Val Leu Phe Met Leu Phe Arg Pro Leu Phe Arg Trp Gln Leu Cys Pro 
                85                  90                  95      


Gly Trp Pro Val Leu Ala Gln Leu Ala Val Gly Ser Ala Leu Phe Ser 
            100                 105                 110         


Ile Val Val Pro Val Leu Ala Pro Gly Leu Gly Ser Thr Arg Ser Ser 
        115                 120                 125             


Ala Leu Cys Ser Leu Gly Tyr Cys Val Trp Tyr Gly Ser Ala Phe Ala 
    130                 135                 140                 


Gln Ala Leu Leu Leu Gly Cys His Ala Ser Leu Gly His Arg Leu Gly 
145                 150                 155                 160 


Ala Gly Gln Val Pro Gly Leu Thr Leu Gly Leu Thr Val Gly Ile Trp 
                165                 170                 175     


Gly Val Ala Ala Leu Leu Thr Leu Pro Val Thr Leu Ala Ser Gly Ala 
            180                 185                 190         


Ser Gly Gly Leu Cys Thr Leu Ile Tyr Ser Thr Glu Leu Lys Ala Leu 
        195                 200                 205             


Gln Ala Thr His Thr Val Ala Cys Leu Ala Ile Phe Val Leu Leu Pro 
    210                 215                 220                 


Leu Gly Leu Phe Gly Ala Lys Gly Leu Lys Lys Ala Leu Gly Met Gly 
225                 230                 235                 240 


Pro Gly Pro Trp Met Asn Ile Leu Trp Ala Trp Phe Ile Phe Trp Trp 
                245                 250                 255     


Pro His Gly Val Val Leu Gly Leu Asp Phe Leu Val Arg Ser Lys Leu 
            260                 265                 270         


Leu Leu Leu Ser Thr Cys Leu Ala Gln Gln Ala Leu Asp Leu Leu Leu 
        275                 280                 285             


Asn Leu Ala Glu Ala Leu Ala Ile Leu His Cys Val Ala Thr Pro Leu 
    290                 295                 300                 


Leu Leu Ala Leu Phe Cys His Gln Ala Thr Arg Thr Leu Leu Pro Ser 
305                 310                 315                 320 


Leu Pro Leu Pro Glu Gly Trp Ser Ser His Leu Asp Thr Leu Gly Ser 
                325                 330                 335     


Lys Ser 
        


<210>  1294
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  1294

Met Cys Ser Thr Met Ser Ala Pro Thr Cys Leu Ala His Leu Pro Pro 
1               5                   10                  15      


Cys Phe Leu Leu Leu Ala Leu Val Leu Val Pro Ser Asp Ala Ser Gly 
            20                  25                  30          


Gln Ser Ser Arg Asn Asp Trp Gln Val Leu Gln Pro Glu Gly Pro Met 
        35                  40                  45              


Leu Val Ala Glu Gly Glu Thr Leu Leu Leu Arg Cys Met Val Val Gly 
    50                  55                  60                  


Ser Cys Thr Asp Gly Met Ile Lys Trp Val Lys Val Ser Thr Gln Asp 
65                  70                  75                  80  


Gln Gln Glu Ile Tyr Asn Phe Lys Arg Gly Ser Phe Pro Gly Val Met 
                85                  90                  95      


Pro Met Ile Gln Arg Thr Ser Glu Pro Leu Asn Cys Asp Tyr Ser Ile 
            100                 105                 110         


Tyr Ile His Asn Val Thr Arg Glu His Thr Gly Thr Tyr His Cys Val 
        115                 120                 125             


Arg Phe Asp Gly Leu Ser Glu His Ser Glu Met Lys Ser Asp Glu Gly 
    130                 135                 140                 


Thr Ser Val Leu Val Lys Gly Ala Gly Asp Pro Glu Pro Asp Leu Trp 
145                 150                 155                 160 


Ile Ile Gln Pro Gln Glu Leu Val Leu Gly Thr Thr Gly Asp Thr Val 
                165                 170                 175     


Phe Leu Asn Cys Thr Val Leu Gly Asp Gly Pro Pro Gly Pro Ile Arg 
            180                 185                 190         


Trp Phe Gln Gly Ala Gly Leu Ser Arg Glu Ala Ile Tyr Asn Phe Gly 
        195                 200                 205             


Gly Ile Ser His Pro Lys Glu Thr Ala Val Gln Ala Ser Asn Asn Asp 
    210                 215                 220                 


Phe Ser Ile Leu Leu Gln Asn Val Ser Ser Glu Asp Ala Gly Thr Tyr 
225                 230                 235                 240 


Tyr Cys Val Lys Phe Gln Arg Lys Pro Asn Arg Gln Tyr Leu Ser Gly 
                245                 250                 255     


Gln Gly Thr Ser Leu Lys Val Lys Ala Lys Ser Thr Ser Ser Lys Glu 
            260                 265                 270         


Ala Glu Phe Thr Ser Glu Pro Ala Thr Glu Met Ser Pro Thr Gly Leu 
        275                 280                 285             


Leu Val Val Phe Ala Pro Val Val Leu Gly Leu Lys Ala Ile Thr Leu 
    290                 295                 300                 


Ala Ala Leu Leu Leu Ala Leu Ala Thr Ser Arg Arg Ser Pro Gly Gln 
305                 310                 315                 320 


Glu Asp Val Lys Thr Thr Gly Pro Ala Gly Ala Met Asn Thr Leu Ala 
                325                 330                 335     


Trp Ser Lys Gly Gln Glu 
            340         


<210>  1295
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  1295

Met Leu Ser Thr Ser Arg Ser Arg Phe Ile Arg Asn Thr Asn Glu Ser 
1               5                   10                  15      


Gly Glu Glu Val Thr Thr Phe Phe Asp Tyr Asp Tyr Gly Ala Pro Cys 
            20                  25                  30          


His Lys Phe Asp Val Lys Gln Ile Gly Ala Gln Leu Leu Pro Pro Leu 
        35                  40                  45              


Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn Met Leu Val Val 
    50                  55                  60                  


Leu Ile Leu Ile Asn Cys Lys Lys Leu Lys Cys Leu Thr Asp Ile Tyr 
65                  70                  75                  80  


Leu Leu Asn Leu Ala Ile Ser Asp Leu Leu Phe Leu Ile Thr Leu Pro 
                85                  90                  95      


Leu Trp Ala His Ser Ala Ala Asn Glu Trp Val Phe Gly Asn Ala Met 
            100                 105                 110         


Cys Lys Leu Phe Thr Gly Leu Tyr His Ile Gly Tyr Phe Gly Gly Ile 
        115                 120                 125             


Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu Ala Ile Val His 
    130                 135                 140                 


Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe Gly Val Val Thr 
145                 150                 155                 160 


Ser Val Ile Thr Trp Leu Val Ala Val Phe Ala Ser Val Pro Gly Ile 
                165                 170                 175     


Ile Phe Thr Lys Cys Gln Lys Glu Asp Ser Val Tyr Val Cys Gly Pro 
            180                 185                 190         


Tyr Phe Pro Arg Gly Trp Asn Asn Phe His Thr Ile Met Arg Asn Ile 
        195                 200                 205             


Leu Gly Leu Val Leu Pro Leu Leu Ile Met Val Ile Cys Tyr Ser Gly 
    210                 215                 220                 


Ile Leu Lys Thr Leu Leu Arg Cys Arg Asn Glu Lys Lys Arg His Arg 
225                 230                 235                 240 


Ala Val Arg Val Ile Phe Thr Ile Met Ile Val Tyr Phe Leu Phe Trp 
                245                 250                 255     


Thr Pro Tyr Asn Ile Val Ile Leu Leu Asn Thr Phe Gln Glu Phe Phe 
            260                 265                 270         


Gly Leu Ser Asn Cys Glu Ser Thr Ser Gln Leu Asp Gln Ala Thr Gln 
        275                 280                 285             


Val Thr Glu Thr Leu Gly Met Thr His Cys Cys Ile Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Ala Phe Val Gly Glu Lys Phe Arg Ser Leu Phe His Ile Ala Leu 
305                 310                 315                 320 


Gly Cys Arg Ile Ala Pro Leu Gln Lys Pro Val Cys Gly Gly Pro Gly 
                325                 330                 335     


Val Arg Pro Gly Lys Asn Val Lys Val Thr Thr Gln Gly Leu Leu Asp 
            340                 345                 350         


Gly Arg Gly Lys Gly Lys Ser Ile Gly Arg Ala Pro Glu Ala Ser Leu 
        355                 360                 365             


Gln Asp Lys Glu Gly Ala 
    370                 


<210>  1296
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  1296

Met Ala Asn Ser Gly Leu Gln Leu Leu Gly Tyr Phe Leu Ala Leu Gly 
1               5                   10                  15      


Gly Trp Val Gly Ile Ile Ala Ser Thr Ala Leu Pro Gln Trp Lys Gln 
            20                  25                  30          


Ser Ser Tyr Ala Gly Asp Ala Ile Ile Thr Ala Val Gly Leu Tyr Glu 
        35                  40                  45              


Gly Leu Trp Met Ser Cys Ala Ser Gln Ser Thr Gly Gln Val Gln Cys 
    50                  55                  60                  


Lys Leu Tyr Asp Ser Leu Leu Ala Leu Asp Gly His Ile Gln Ser Ala 
65                  70                  75                  80  


Arg Ala Leu Met Val Val Ala Val Leu Leu Gly Phe Val Ala Met Val 
                85                  90                  95      


Leu Ser Val Val Gly Met Lys Cys Thr Arg Val Gly Asp Ser Asn Pro 
            100                 105                 110         


Ile Ala Lys Gly Arg Val Ala Ile Ala Gly Gly Ala Leu Phe Ile Leu 
        115                 120                 125             


Ala Gly Leu Cys Thr Leu Thr Ala Val Ser Trp Tyr Ala Thr Leu Val 
    130                 135                 140                 


Thr Gln Glu Phe Phe Asn Pro Ser Thr Pro Val Asn Ala Arg Tyr Glu 
145                 150                 155                 160 


Phe Gly Pro Ala Leu Phe Val Gly Trp Ala Ser Ala Gly Leu Ala Val 
                165                 170                 175     


Leu Gly Gly Ser Phe Leu Cys Cys Thr Cys Pro Glu Pro Glu Arg Pro 
            180                 185                 190         


Asn Ser Ser Pro Gln Pro Tyr Arg Pro Gly Pro Ser Ala Ala Ala Arg 
        195                 200                 205             


Glu Tyr Val 
    210     


<210>  1297
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  1297

Met Leu Ser Thr Ser Arg Ser Arg Phe Ile Arg Asn Thr Asn Glu Ser 
1               5                   10                  15      


Gly Glu Glu Val Thr Thr Phe Phe Asp Tyr Asp Tyr Gly Ala Pro Cys 
            20                  25                  30          


His Lys Phe Asp Val Lys Gln Ile Gly Ala Gln Leu Leu Pro Pro Leu 
        35                  40                  45              


Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn Met Leu Val Val 
    50                  55                  60                  


Leu Ile Leu Ile Asn Cys Lys Lys Leu Lys Cys Leu Thr Asp Ile Tyr 
65                  70                  75                  80  


Leu Leu Asn Leu Ala Ile Ser Asp Leu Leu Phe Leu Ile Thr Leu Pro 
                85                  90                  95      


Leu Trp Ala His Ser Ala Ala Asn Glu Trp Val Phe Gly Asn Ala Met 
            100                 105                 110         


Cys Lys Leu Phe Thr Gly Leu Tyr His Ile Gly Tyr Phe Gly Gly Ile 
        115                 120                 125             


Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu Ala Ile Val His 
    130                 135                 140                 


Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe Gly Val Val Thr 
145                 150                 155                 160 


Ser Val Ile Thr Trp Leu Val Ala Val Phe Ala Ser Val Pro Gly Ile 
                165                 170                 175     


Ile Phe Thr Lys Cys Gln Lys Glu Asp Ser Val Tyr Val Cys Gly Pro 
            180                 185                 190         


Tyr Phe Pro Arg Gly Trp Asn Asn Phe His Thr Ile Met Arg Asn Ile 
        195                 200                 205             


Leu Gly Leu Val Leu Pro Leu Leu Ile Met Val Ile Cys Tyr Ser Gly 
    210                 215                 220                 


Ile Leu Lys Thr Leu Leu Arg Cys Arg Asn Glu Lys Lys Arg His Arg 
225                 230                 235                 240 


Ala Val Arg Val Ile Phe Thr Ile Met Ile Val Tyr Phe Leu Phe Trp 
                245                 250                 255     


Thr Pro Tyr Asn Ile Val Ile Leu Leu Asn Thr Phe Gln Glu Phe Phe 
            260                 265                 270         


Gly Leu Ser Asn Cys Glu Ser Thr Ser Gln Leu Asp Gln Ala Thr Gln 
        275                 280                 285             


Val Thr Glu Thr Leu Gly Met Thr His Cys Cys Ile Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Ala Phe Val Gly Glu Lys Phe Arg Arg Tyr Leu Ser Val Phe Phe 
305                 310                 315                 320 


Arg Lys His Ile Thr Lys Arg Phe Cys Lys Gln Cys Pro Val Phe Tyr 
                325                 330                 335     


Arg Glu Thr Val Asp Gly Val Thr Ser Thr Asn Thr Pro Ser Thr Gly 
            340                 345                 350         


Glu Gln Glu Val Ser Ala Gly Leu 
        355                 360 


<210>  1298
<211>  549
<212>  PRT
<213>  Homo sapiens

<400>  1298

Met Met Cys Leu Glu Cys Ala Ser Ala Ala Ala Gly Gly Ala Glu Glu 
1               5                   10                  15      


Glu Glu Ala Asp Ala Glu Arg Arg Arg Arg Arg Arg Gly Ala Gln Arg 
            20                  25                  30          


Gly Ala Gly Gly Ser Gly Cys Cys Gly Ala Arg Gly Ala Gly Gly Ala 
        35                  40                  45              


Gly Val Ser Ala Ala Gly Asp Glu Val Gln Thr Leu Ser Gly Ser Val 
    50                  55                  60                  


Arg Arg Ala Pro Thr Gly Pro Pro Gly Thr Pro Gly Thr Pro Gly Cys 
65                  70                  75                  80  


Ala Ala Thr Ala Lys Gly Pro Gly Ala Gln Gln Pro Lys Pro Ala Ser 
                85                  90                  95      


Leu Gly Arg Gly Arg Gly Ala Ala Ala Ala Ile Leu Ser Leu Gly Asn 
            100                 105                 110         


Val Leu Asn Tyr Leu Asp Arg Tyr Thr Val Ala Gly Val Leu Leu Asp 
        115                 120                 125             


Ile Gln Gln His Phe Gly Val Lys Asp Arg Gly Ala Gly Leu Leu Gln 
    130                 135                 140                 


Ser Val Phe Ile Cys Ser Phe Met Val Ala Ala Pro Ile Phe Gly Tyr 
145                 150                 155                 160 


Leu Gly Asp Arg Phe Asn Arg Lys Val Ile Leu Ser Cys Gly Ile Phe 
                165                 170                 175     


Phe Trp Ser Ala Val Thr Phe Ser Ser Ser Phe Ile Pro Gln Gln Tyr 
            180                 185                 190         


Phe Trp Leu Leu Val Leu Ser Arg Gly Leu Val Gly Ile Gly Glu Ala 
        195                 200                 205             


Ser Tyr Ser Thr Ile Ala Pro Thr Ile Ile Gly Asp Leu Phe Thr Lys 
    210                 215                 220                 


Asn Thr Arg Thr Leu Met Leu Ser Val Phe Tyr Phe Ala Ile Pro Leu 
225                 230                 235                 240 


Gly Ser Gly Leu Gly Tyr Ile Thr Gly Ser Ser Val Lys Gln Ala Ala 
                245                 250                 255     


Gly Asp Trp His Trp Ala Leu Arg Val Ser Pro Val Leu Gly Met Ile 
            260                 265                 270         


Thr Gly Thr Leu Ile Leu Ile Leu Val Pro Ala Thr Lys Arg Gly His 
        275                 280                 285             


Ala Asp Gln Leu Gly Asp Gln Leu Lys Ala Arg Thr Ser Trp Leu Arg 
    290                 295                 300                 


Asp Met Lys Ala Leu Ile Arg Asn Arg Ser Tyr Val Phe Ser Ser Leu 
305                 310                 315                 320 


Ala Thr Ser Ala Val Ser Phe Ala Thr Gly Ala Leu Gly Met Trp Ile 
                325                 330                 335     


Pro Leu Tyr Leu His Arg Ala Gln Val Val Gln Lys Thr Ala Glu Thr 
            340                 345                 350         


Cys Asn Ser Pro Pro Cys Gly Ala Lys Asp Ser Leu Ile Phe Gly Ala 
        355                 360                 365             


Ile Thr Cys Phe Thr Gly Phe Leu Gly Val Val Thr Gly Ala Gly Ala 
    370                 375                 380                 


Thr Arg Trp Cys Arg Leu Lys Thr Gln Arg Ala Asp Pro Leu Val Cys 
385                 390                 395                 400 


Ala Val Gly Met Leu Gly Ser Ala Ile Phe Ile Cys Leu Ile Phe Val 
                405                 410                 415     


Ala Ala Lys Ser Ser Ile Val Gly Ala Tyr Ile Cys Ile Phe Val Gly 
            420                 425                 430         


Glu Thr Leu Leu Phe Ser Asn Trp Ala Ile Thr Ala Asp Ile Leu Met 
        435                 440                 445             


Tyr Val Val Ile Pro Thr Arg Arg Ala Thr Ala Val Ala Leu Gln Ser 
    450                 455                 460                 


Phe Thr Ser His Leu Leu Gly Asp Ala Gly Ser Pro Tyr Leu Ile Gly 
465                 470                 475                 480 


Phe Ile Ser Asp Leu Ile Arg Gln Ser Thr Lys Asp Ser Pro Leu Trp 
                485                 490                 495     


Glu Phe Leu Ser Leu Gly Tyr Ala Leu Met Leu Cys Pro Phe Val Val 
            500                 505                 510         


Val Leu Gly Gly Met Phe Phe Leu Ala Thr Ala Leu Phe Phe Val Ser 
        515                 520                 525             


Asp Arg Ala Arg Ala Glu Gln Gln Val Asn Gln Leu Ala Met Pro Pro 
    530                 535                 540                 


Ala Ser Val Lys Val 
545                 


<210>  1299
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  1299

Met Phe Thr Arg Ala Gln Val Arg Arg Ile Leu Gln Arg Val Pro Gly 
1               5                   10                  15      


Lys Gln Arg Phe Gly Ile Tyr Arg Phe Leu Pro Phe Phe Phe Val Leu 
            20                  25                  30          


Gly Gly Thr Met Glu Trp Ile Met Ile Lys Val Arg Val Gly Gln Glu 
        35                  40                  45              


Thr Phe Tyr Asp Val Tyr Arg Arg Lys Ala Ser Glu Arg Gln Tyr Gln 
    50                  55                  60                  


Arg Arg Leu Glu Asp Glu 
65                  70  


<210>  1300
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  1300

Met Lys Glu Thr Arg Gly Tyr Gly Gly Asp Ala Pro Phe Cys Thr Arg 
1               5                   10                  15      


Leu Asn His Ser Tyr Thr Gly Met Trp Ala Pro Glu Arg Ser Ala Glu 
            20                  25                  30          


Ala Arg Gly Asn Leu Thr Arg Pro Pro Gly Ser Gly Glu Asp Cys Gly 
        35                  40                  45              


Ser Val Ser Val Ala Phe Pro Ile Thr Met Leu Leu Thr Gly Phe Val 
    50                  55                  60                  


Gly Asn Ala Leu Ala Met Leu Leu Val Ser Arg Ser Tyr Arg Arg Arg 
65                  70                  75                  80  


Glu Ser Lys Arg Lys Lys Ser Phe Leu Leu Cys Ile Gly Trp Leu Ala 
                85                  90                  95      


Leu Thr Asp Leu Val Gly Gln Leu Leu Thr Thr Pro Val Val Ile Val 
            100                 105                 110         


Val Tyr Leu Ser Lys Gln Arg Trp Glu His Ile Asp Pro Ser Gly Arg 
        115                 120                 125             


Leu Cys Thr Phe Phe Gly Leu Thr Met Thr Val Phe Gly Leu Ser Ser 
    130                 135                 140                 


Leu Phe Ile Ala Ser Ala Met Ala Val Glu Arg Ala Leu Ala Ile Arg 
145                 150                 155                 160 


Ala Pro His Trp Tyr Ala Ser His Met Lys Thr Arg Ala Thr Arg Ala 
                165                 170                 175     


Val Leu Leu Gly Val Trp Leu Ala Val Leu Ala Phe Ala Leu Leu Pro 
            180                 185                 190         


Val Leu Gly Val Gly Gln Tyr Thr Val Gln Trp Pro Gly Thr Trp Cys 
        195                 200                 205             


Phe Ile Ser Thr Gly Arg Gly Gly Asn Gly Thr Ser Ser Ser His Asn 
    210                 215                 220                 


Trp Gly Asn Leu Phe Phe Ala Ser Ala Phe Ala Phe Leu Gly Leu Leu 
225                 230                 235                 240 


Ala Leu Thr Val Thr Phe Ser Cys Asn Leu Ala Thr Ile Lys Ala Leu 
                245                 250                 255     


Val Ser Arg Cys Arg Ala Lys Ala Thr Ala Ser Gln Ser Ser Ala Gln 
            260                 265                 270         


Trp Gly Arg Ile Thr Thr Glu Thr Ala Ile Gln Leu Met Gly Ile Met 
        275                 280                 285             


Cys Val Leu Ser Val Cys Trp Ser Pro Leu Leu Ile Met Met Leu Lys 
    290                 295                 300                 


Met Ile Phe Asn Gln Thr Ser Val Glu His Cys Lys Thr His Thr Glu 
305                 310                 315                 320 


Lys Gln Lys Glu Cys Asn Phe Phe Leu Ile Ala Val Arg Leu Ala Ser 
                325                 330                 335     


Leu Asn Gln Ile Leu Asp Pro Trp Val Tyr Leu Leu Leu Arg Lys Ile 
            340                 345                 350         


Leu Leu Arg Lys Phe Cys Gln Ile Arg Tyr His Thr Asn Asn Tyr Ala 
        355                 360                 365             


Ser Ser Ser Thr Ser Leu Pro Cys Gln Cys Ser Ser Thr Leu Met Trp 
    370                 375                 380                 


Ser Asp His Leu Glu Arg 
385                 390 


<210>  1301
<211>  511
<212>  PRT
<213>  Homo sapiens

<400>  1301

Met Val Asp Ser Thr Glu Tyr Glu Val Ala Ser Gln Pro Glu Val Glu 
1               5                   10                  15      


Thr Ser Pro Leu Gly Asp Gly Ala Ser Pro Gly Pro Glu Gln Val Lys 
            20                  25                  30          


Leu Lys Lys Glu Ile Ser Leu Leu Asn Gly Val Cys Leu Ile Val Gly 
        35                  40                  45              


Asn Met Ile Gly Ser Gly Ile Phe Val Ser Pro Lys Gly Val Leu Ile 
    50                  55                  60                  


Tyr Ser Ala Ser Phe Gly Leu Ser Leu Val Ile Trp Ala Val Gly Gly 
65                  70                  75                  80  


Leu Phe Ser Val Phe Gly Ala Leu Cys Tyr Ala Glu Leu Gly Thr Thr 
                85                  90                  95      


Ile Lys Lys Ser Gly Ala Ser Tyr Ala Tyr Ile Leu Glu Ala Phe Gly 
            100                 105                 110         


Gly Phe Leu Ala Phe Ile Arg Leu Trp Thr Ser Leu Leu Ile Ile Glu 
        115                 120                 125             


Pro Thr Ser Gln Ala Ile Ile Ala Ile Thr Phe Ala Asn Tyr Met Val 
    130                 135                 140                 


Gln Pro Leu Phe Pro Ser Cys Phe Ala Pro Tyr Ala Ala Ser Arg Leu 
145                 150                 155                 160 


Leu Ala Ala Ala Cys Ile Cys Leu Leu Thr Phe Ile Asn Cys Ala Tyr 
                165                 170                 175     


Val Lys Trp Gly Thr Leu Val Gln Asp Ile Phe Thr Tyr Ala Lys Val 
            180                 185                 190         


Leu Ala Leu Ile Ala Val Ile Val Ala Gly Ile Val Arg Leu Gly Gln 
        195                 200                 205             


Gly Ala Ser Thr His Phe Glu Asn Ser Phe Glu Gly Ser Ser Phe Ala 
    210                 215                 220                 


Val Gly Asp Ile Ala Leu Ala Leu Tyr Ser Ala Leu Phe Ser Tyr Ser 
225                 230                 235                 240 


Gly Trp Asp Thr Leu Asn Tyr Val Thr Glu Glu Ile Lys Asn Pro Glu 
                245                 250                 255     


Arg Asn Leu Pro Leu Ser Ile Gly Ile Ser Met Pro Ile Val Thr Ile 
            260                 265                 270         


Ile Tyr Ile Leu Thr Asn Val Ala Tyr Tyr Thr Val Leu Asp Met Arg 
        275                 280                 285             


Asp Ile Leu Ala Ser Asp Ala Val Ala Val Thr Phe Ala Asp Gln Ile 
    290                 295                 300                 


Phe Gly Ile Phe Asn Trp Ile Ile Pro Leu Ser Val Ala Leu Ser Cys 
305                 310                 315                 320 


Phe Gly Gly Leu Asn Ala Ser Ile Val Ala Ala Ser Arg Leu Phe Phe 
                325                 330                 335     


Val Gly Ser Arg Glu Gly His Leu Pro Asp Ala Ile Cys Met Ile His 
            340                 345                 350         


Val Glu Arg Phe Thr Pro Val Pro Ser Leu Leu Phe Asn Gly Ile Met 
        355                 360                 365             


Ala Leu Ile Tyr Leu Cys Val Glu Asp Ile Phe Gln Leu Ile Asn Tyr 
    370                 375                 380                 


Tyr Ser Phe Ser Tyr Trp Phe Phe Val Gly Leu Ser Ile Val Gly Gln 
385                 390                 395                 400 


Leu Tyr Leu Arg Trp Lys Glu Pro Asp Arg Pro Arg Pro Leu Lys Leu 
                405                 410                 415     


Ser Val Phe Phe Pro Ile Val Phe Cys Leu Cys Thr Ile Phe Leu Val 
            420                 425                 430         


Ala Val Pro Leu Tyr Ser Asp Thr Ile Asn Ser Leu Ile Gly Ile Ala 
        435                 440                 445             


Ile Ala Leu Ser Gly Leu Pro Phe Tyr Phe Leu Ile Ile Arg Val Pro 
    450                 455                 460                 


Glu His Lys Arg Pro Leu Tyr Leu Arg Arg Ile Val Gly Ser Ala Thr 
465                 470                 475                 480 


Arg Tyr Leu Gln Val Leu Cys Met Ser Val Ala Ala Glu Met Asp Leu 
                485                 490                 495     


Glu Asp Gly Gly Glu Met Pro Lys Gln Arg Asp Pro Lys Ser Asn 
            500                 505                 510     


<210>  1302
<211>  511
<212>  PRT
<213>  Homo sapiens

<400>  1302

Met Val Asp Ser Thr Glu Tyr Glu Val Ala Ser Gln Pro Glu Val Glu 
1               5                   10                  15      


Thr Ser Pro Leu Gly Asp Gly Ala Ser Pro Gly Pro Glu Gln Val Lys 
            20                  25                  30          


Leu Lys Lys Glu Ile Ser Leu Leu Asn Gly Val Cys Leu Ile Val Gly 
        35                  40                  45              


Asn Met Ile Gly Ser Gly Ile Phe Val Ser Pro Lys Gly Val Leu Ile 
    50                  55                  60                  


Tyr Ser Ala Ser Phe Gly Leu Ser Leu Val Ile Trp Ala Val Gly Gly 
65                  70                  75                  80  


Leu Phe Ser Val Phe Gly Ala Leu Cys Tyr Ala Glu Leu Gly Thr Thr 
                85                  90                  95      


Ile Lys Lys Ser Gly Ala Ser Tyr Ala Tyr Ile Leu Glu Ala Phe Gly 
            100                 105                 110         


Gly Phe Leu Ala Phe Ile Arg Leu Trp Thr Ser Leu Leu Ile Ile Glu 
        115                 120                 125             


Pro Thr Ser Gln Ala Ile Ile Ala Ile Thr Phe Ala Asn Tyr Met Val 
    130                 135                 140                 


Gln Pro Leu Phe Pro Ser Cys Phe Ala Pro Tyr Ala Ala Ser Arg Leu 
145                 150                 155                 160 


Leu Ala Ala Ala Cys Ile Cys Leu Leu Thr Phe Ile Asn Cys Ala Tyr 
                165                 170                 175     


Val Lys Trp Gly Thr Leu Val Gln Asp Ile Phe Thr Tyr Ala Lys Val 
            180                 185                 190         


Leu Ala Leu Ile Ala Val Ile Val Ala Gly Ile Val Arg Leu Gly Gln 
        195                 200                 205             


Gly Ala Ser Thr His Phe Glu Asn Ser Phe Glu Gly Ser Ser Phe Ala 
    210                 215                 220                 


Val Gly Asp Ile Ala Leu Ala Leu Tyr Ser Ala Leu Phe Ser Tyr Ser 
225                 230                 235                 240 


Gly Trp Asp Thr Leu Asn Tyr Val Thr Glu Glu Ile Lys Asn Pro Glu 
                245                 250                 255     


Arg Asn Leu Pro Leu Ser Ile Gly Ile Ser Met Pro Ile Val Thr Ile 
            260                 265                 270         


Ile Tyr Ile Leu Thr Asn Val Ala Tyr Tyr Thr Val Leu Asp Met Arg 
        275                 280                 285             


Asp Ile Leu Ala Ser Asp Ala Val Ala Val Thr Phe Ala Asp Gln Ile 
    290                 295                 300                 


Phe Gly Ile Phe Asn Trp Ile Ile Pro Leu Ser Val Ala Leu Ser Cys 
305                 310                 315                 320 


Phe Gly Gly Leu Asn Ala Ser Ile Val Ala Ala Ser Arg Leu Phe Phe 
                325                 330                 335     


Val Gly Ser Arg Glu Gly His Leu Pro Asp Ala Ile Cys Met Ile His 
            340                 345                 350         


Val Glu Arg Phe Thr Pro Val Pro Ser Leu Leu Phe Asn Gly Ile Met 
        355                 360                 365             


Ala Leu Ile Tyr Leu Cys Val Glu Asp Ile Phe Gln Leu Ile Asn Tyr 
    370                 375                 380                 


Tyr Ser Phe Ser Tyr Trp Phe Phe Val Gly Leu Ser Ile Val Gly Gln 
385                 390                 395                 400 


Leu Tyr Leu Arg Trp Lys Glu Pro Asp Arg Pro Arg Pro Leu Lys Leu 
                405                 410                 415     


Ser Val Phe Phe Pro Ile Val Phe Cys Leu Cys Thr Ile Phe Leu Val 
            420                 425                 430         


Ala Val Pro Leu Tyr Ser Asp Thr Ile Asn Ser Leu Ile Gly Ile Ala 
        435                 440                 445             


Ile Ala Leu Ser Gly Leu Pro Phe Tyr Phe Leu Ile Ile Arg Val Pro 
    450                 455                 460                 


Glu His Lys Arg Pro Leu Tyr Leu Arg Arg Ile Val Gly Ser Ala Thr 
465                 470                 475                 480 


Arg Tyr Leu Gln Val Leu Cys Met Ser Val Ala Ala Glu Met Asp Leu 
                485                 490                 495     


Glu Asp Gly Gly Glu Met Pro Lys Gln Arg Asp Pro Lys Ser Asn 
            500                 505                 510     


<210>  1303
<211>  1029
<212>  PRT
<213>  Homo sapiens

<400>  1303

Met Ala Glu Leu Pro Thr Thr Glu Thr Pro Gly Asp Ala Thr Leu Cys 
1               5                   10                  15      


Ser Gly Arg Phe Thr Ile Ser Thr Leu Leu Ser Ser Asp Glu Pro Ser 
            20                  25                  30          


Pro Pro Ala Ala Tyr Asp Ser Ser His Pro Ser His Leu Thr His Ser 
        35                  40                  45              


Ser Thr Phe Cys Met Arg Thr Phe Gly Tyr Asn Thr Ile Asp Val Val 
    50                  55                  60                  


Pro Thr Tyr Glu His Tyr Ala Asn Ser Thr Gln Pro Gly Glu Pro Arg 
65                  70                  75                  80  


Lys Val Arg Pro Thr Leu Ala Asp Leu His Ser Phe Leu Lys Glu Gly 
                85                  90                  95      


Arg His Leu His Ala Leu Ala Phe Asp Ser Arg Pro Ser His Glu Met 
            100                 105                 110         


Thr Asp Gly Leu Val Glu Gly Glu Ala Gly Thr Ser Ser Glu Lys Asn 
        115                 120                 125             


Pro Glu Glu Pro Val Arg Phe Gly Trp Val Lys Gly Val Met Ile Arg 
    130                 135                 140                 


Cys Met Leu Asn Ile Trp Gly Val Ile Leu Tyr Leu Arg Leu Pro Trp 
145                 150                 155                 160 


Ile Thr Ala Gln Ala Gly Ile Val Leu Thr Trp Ile Ile Ile Leu Leu 
                165                 170                 175     


Ser Val Thr Val Thr Ser Ile Thr Gly Leu Ser Ile Ser Ala Ile Ser 
            180                 185                 190         


Thr Asn Gly Lys Val Lys Ser Gly Gly Thr Tyr Phe Leu Ile Ser Arg 
        195                 200                 205             


Ser Leu Gly Pro Glu Leu Gly Gly Ser Ile Gly Leu Ile Phe Ala Phe 
    210                 215                 220                 


Ala Asn Ala Val Gly Val Ala Met His Thr Val Gly Phe Ala Glu Thr 
225                 230                 235                 240 


Val Arg Asp Leu Leu Gln Glu Tyr Gly Ala Pro Ile Val Asp Pro Ile 
                245                 250                 255     


Asn Asp Ile Arg Ile Ile Gly Val Val Ser Val Thr Val Leu Leu Ala 
            260                 265                 270         


Ile Ser Leu Ala Gly Met Glu Trp Glu Ser Lys Ala Gln Val Leu Phe 
        275                 280                 285             


Phe Leu Val Ile Met Val Ser Phe Ala Asn Tyr Leu Val Gly Thr Leu 
    290                 295                 300                 


Ile Pro Pro Ser Glu Asp Lys Ala Ser Lys Gly Phe Phe Ser Tyr Arg 
305                 310                 315                 320 


Ala Asp Ile Phe Val Gln Asn Leu Val Pro Asp Trp Arg Gly Pro Asp 
                325                 330                 335     


Gly Thr Phe Phe Gly Met Phe Ser Ile Phe Phe Pro Ser Ala Thr Gly 
            340                 345                 350         


Ile Leu Ala Gly Ala Asn Ile Ser Gly Asp Leu Lys Asp Pro Ala Ile 
        355                 360                 365             


Ala Ile Pro Lys Gly Thr Leu Met Ala Ile Phe Trp Thr Thr Ile Ser 
    370                 375                 380                 


Tyr Leu Ala Ile Ser Ala Thr Ile Gly Ser Cys Val Val Arg Asp Ala 
385                 390                 395                 400 


Ser Gly Val Leu Asn Asp Thr Val Thr Pro Gly Trp Gly Ala Cys Glu 
                405                 410                 415     


Gly Leu Ala Cys Ser Tyr Gly Trp Asn Phe Thr Glu Cys Thr Gln Gln 
            420                 425                 430         


His Ser Cys His Tyr Gly Leu Ile Asn Tyr Tyr Gln Thr Met Ser Met 
        435                 440                 445             


Val Ser Gly Phe Ala Pro Leu Ile Thr Ala Gly Ile Phe Gly Ala Thr 
    450                 455                 460                 


Leu Ser Ser Ala Leu Ala Cys Leu Val Ser Ala Ala Lys Val Phe Gln 
465                 470                 475                 480 


Cys Leu Cys Glu Asp Gln Leu Tyr Pro Leu Ile Gly Phe Phe Gly Lys 
                485                 490                 495     


Gly Tyr Gly Lys Asn Lys Glu Pro Val Arg Gly Tyr Leu Leu Ala Tyr 
            500                 505                 510         


Ala Ile Ala Val Ala Phe Ile Ile Ile Ala Glu Leu Asn Thr Ile Ala 
        515                 520                 525             


Pro Ile Ile Ser Asn Phe Phe Leu Cys Ser Tyr Ala Leu Ile Asn Phe 
    530                 535                 540                 


Ser Cys Phe His Ala Ser Ile Thr Asn Ser Pro Gly Trp Arg Pro Ser 
545                 550                 555                 560 


Phe Gln Tyr Tyr Asn Lys Trp Ala Ala Leu Phe Gly Ala Ile Ile Ser 
                565                 570                 575     


Val Val Ile Met Phe Leu Leu Thr Trp Trp Ala Ala Leu Ile Ala Ile 
            580                 585                 590         


Gly Val Val Leu Phe Leu Leu Leu Tyr Val Ile Tyr Lys Lys Pro Glu 
        595                 600                 605             


Val Asn Trp Gly Ser Ser Val Gln Ala Gly Ser Tyr Asn Leu Ala Leu 
    610                 615                 620                 


Ser Tyr Ser Val Gly Leu Asn Glu Val Glu Asp His Ile Lys Asn Tyr 
625                 630                 635                 640 


Arg Pro Gln Cys Leu Val Leu Thr Gly Pro Pro Asn Phe Arg Pro Ala 
                645                 650                 655     


Leu Val Asp Phe Val Gly Thr Phe Thr Arg Asn Leu Ser Leu Met Ile 
            660                 665                 670         


Cys Gly His Val Leu Ile Gly Pro His Lys Gln Arg Met Pro Glu Leu 
        675                 680                 685             


Gln Leu Ile Ala Asn Gly His Thr Lys Trp Leu Asn Lys Arg Lys Ile 
    690                 695                 700                 


Lys Ala Phe Tyr Ser Asp Val Ile Ala Glu Asp Leu Arg Arg Gly Val 
705                 710                 715                 720 


Gln Ile Leu Met Gln Ala Ala Gly Leu Gly Arg Met Lys Pro Asn Ile 
                725                 730                 735     


Leu Val Val Gly Phe Lys Lys Asn Trp Gln Ser Ala His Pro Ala Thr 
            740                 745                 750         


Val Glu Asp Tyr Ile Gly Ile Leu His Asp Ala Phe Asp Phe Asn Tyr 
        755                 760                 765             


Gly Val Cys Val Met Arg Met Arg Glu Gly Leu Asn Val Ser Lys Met 
    770                 775                 780                 


Met Gln Ala His Ile Asn Pro Val Phe Asp Pro Ala Glu Asp Gly Lys 
785                 790                 795                 800 


Glu Ala Ser Ala Arg Gly Ala Arg Pro Ser Val Ser Gly Ala Leu Asp 
                805                 810                 815     


Pro Lys Ala Leu Val Lys Glu Glu Gln Ala Thr Thr Ile Phe Gln Ser 
            820                 825                 830         


Glu Gln Gly Lys Lys Thr Ile Asp Ile Tyr Trp Leu Phe Asp Asp Gly 
        835                 840                 845             


Gly Leu Thr Leu Leu Ile Pro Tyr Leu Leu Gly Arg Lys Arg Arg Trp 
    850                 855                 860                 


Ser Lys Cys Lys Ile Arg Val Phe Val Gly Gly Gln Ile Asn Arg Met 
865                 870                 875                 880 


Asp Gln Glu Arg Lys Ala Ile Ile Ser Leu Leu Ser Lys Phe Arg Leu 
                885                 890                 895     


Gly Phe His Glu Val His Ile Leu Pro Asp Ile Asn Gln Asn Pro Arg 
            900                 905                 910         


Ala Glu His Thr Lys Arg Phe Glu Asp Met Ile Ala Pro Phe Arg Leu 
        915                 920                 925             


Asn Asp Gly Phe Lys Asp Glu Ala Thr Val Asn Glu Met Arg Arg Asp 
    930                 935                 940                 


Cys Pro Trp Lys Ile Ser Asp Glu Glu Ile Thr Lys Asn Arg Val Lys 
945                 950                 955                 960 


Ser Leu Arg Gln Val Arg Leu Asn Glu Ile Val Leu Asp Tyr Ser Arg 
                965                 970                 975     


Asp Ala Ala Leu Ile Val Ile Thr Leu Pro Ile Gly Arg Lys Gly Lys 
            980                 985                 990         


Cys Pro Ser Ser Leu Tyr Met Ala  Trp Leu Glu Thr Leu  Ser Gln Asp 
        995                 1000                 1005             


Leu Arg  Pro Pro Val Ile Leu  Ile Arg Gly Asn Gln  Glu Asn Val 
    1010                 1015                 1020             


Leu Thr  Phe Tyr Cys Gln 
    1025                 


<210>  1304
<211>  1021
<212>  PRT
<213>  Homo sapiens

<400>  1304

Met Ala Glu Leu Pro Thr Thr Glu Thr Pro Gly Asp Ala Thr Leu Cys 
1               5                   10                  15      


Ser Gly Arg Phe Thr Ile Ser Thr Leu Leu Ser Ser Asp Glu Pro Ser 
            20                  25                  30          


Pro Pro Ala Ala Tyr Asp Ser Ser His Pro Ser His Leu Thr His Ser 
        35                  40                  45              


Ser Thr Phe Cys Met Arg Thr Phe Gly Tyr Asn Thr Ile Asp Val Val 
    50                  55                  60                  


Pro Thr Tyr Glu His Tyr Ala Asn Ser Thr Gln Pro Gly Glu Pro Arg 
65                  70                  75                  80  


Lys Val Arg Pro Thr Leu Ala Asp Leu His Ser Phe Leu Lys Gln Glu 
                85                  90                  95      


Gly Arg His Leu His Ala Leu Ala Phe Asp Ser Arg Pro Ser His Glu 
            100                 105                 110         


Met Thr Asp Gly Leu Val Glu Gly Glu Ala Gly Thr Ser Ser Glu Lys 
        115                 120                 125             


Asn Pro Glu Glu Pro Val Arg Phe Gly Trp Val Lys Gly Val Met Ile 
    130                 135                 140                 


Arg Cys Met Leu Asn Ile Trp Gly Val Ile Leu Tyr Leu Arg Leu Pro 
145                 150                 155                 160 


Trp Ile Thr Ala Gln Ala Gly Ile Val Leu Thr Trp Ile Ile Ile Leu 
                165                 170                 175     


Leu Ser Val Thr Val Thr Ser Ile Thr Gly Leu Ser Ile Ser Ala Ile 
            180                 185                 190         


Ser Thr Asn Gly Lys Val Lys Ser Gly Gly Thr Tyr Phe Leu Ile Ser 
        195                 200                 205             


Arg Ser Leu Gly Pro Glu Leu Gly Gly Ser Ile Gly Leu Ile Phe Ala 
    210                 215                 220                 


Phe Ala Asn Ala Val Gly Val Ala Met His Thr Val Gly Phe Ala Glu 
225                 230                 235                 240 


Thr Val Arg Asp Leu Leu Gln Glu Tyr Gly Ala Pro Ile Val Asp Pro 
                245                 250                 255     


Ile Asn Asp Ile Arg Ile Ile Gly Val Val Ser Val Thr Val Leu Leu 
            260                 265                 270         


Ala Ile Ser Leu Ala Gly Met Glu Trp Glu Ser Lys Ala Gln Val Leu 
        275                 280                 285             


Phe Phe Leu Val Ile Met Val Ser Phe Ala Asn Tyr Leu Val Gly Thr 
    290                 295                 300                 


Leu Ile Pro Pro Ser Glu Asp Lys Ala Ser Lys Gly Phe Phe Ser Tyr 
305                 310                 315                 320 


Arg Ala Asp Ile Phe Val Gln Asn Leu Val Pro Asp Trp Arg Gly Pro 
                325                 330                 335     


Asp Gly Thr Phe Phe Gly Met Phe Ser Ile Phe Phe Pro Ser Ala Thr 
            340                 345                 350         


Gly Ile Leu Ala Gly Ala Asn Ile Ser Gly Asp Leu Lys Asp Pro Ala 
        355                 360                 365             


Ile Ala Ile Pro Lys Gly Thr Leu Met Ala Ile Phe Trp Thr Thr Ile 
    370                 375                 380                 


Ser Tyr Leu Ala Ile Ser Ala Thr Ile Gly Ser Cys Val Val Arg Asp 
385                 390                 395                 400 


Ala Ser Gly Val Leu Asn Asp Thr Val Thr Pro Gly Trp Gly Ala Cys 
                405                 410                 415     


Glu Gly Leu Ala Cys Ser Tyr Gly Trp Asn Phe Thr Glu Cys Thr Gln 
            420                 425                 430         


Gln His Ser Cys His Tyr Gly Leu Ile Asn Tyr Tyr Gln Thr Met Ser 
        435                 440                 445             


Met Val Ser Gly Phe Ala Pro Leu Ile Thr Ala Gly Ile Phe Gly Ala 
    450                 455                 460                 


Thr Leu Ser Ser Ala Leu Ala Cys Leu Val Ser Ala Ala Lys Val Phe 
465                 470                 475                 480 


Gln Cys Leu Cys Glu Asp Gln Leu Tyr Pro Leu Ile Gly Phe Phe Gly 
                485                 490                 495     


Lys Gly Tyr Gly Lys Asn Lys Glu Pro Val Arg Gly Tyr Leu Leu Ala 
            500                 505                 510         


Tyr Ala Ile Ala Val Ala Phe Ile Ile Ile Ala Glu Leu Asn Thr Ile 
        515                 520                 525             


Ala Pro Ile Ile Ser Asn Phe Phe Leu Cys Ser Tyr Ala Leu Ile Asn 
    530                 535                 540                 


Phe Ser Cys Phe His Ala Ser Ile Thr Asn Ser Pro Gly Trp Arg Pro 
545                 550                 555                 560 


Ser Phe Gln Tyr Tyr Asn Lys Trp Ala Ala Leu Phe Gly Ala Ile Ile 
                565                 570                 575     


Ser Val Val Ile Met Phe Leu Leu Thr Trp Trp Ala Ala Leu Ile Ala 
            580                 585                 590         


Ile Gly Val Val Leu Phe Leu Leu Leu Tyr Val Ile Tyr Lys Lys Pro 
        595                 600                 605             


Glu Val Asn Trp Gly Ser Ser Val Gln Ala Gly Ser Tyr Asn Leu Ala 
    610                 615                 620                 


Leu Ser Tyr Ser Val Gly Leu Asn Glu Val Glu Asp His Ile Lys Asn 
625                 630                 635                 640 


Tyr Arg Pro Gln Cys Leu Val Leu Thr Gly Pro Pro Asn Phe Arg Pro 
                645                 650                 655     


Ala Leu Val Asp Phe Val Gly Thr Phe Thr Arg Asn Leu Ser Leu Met 
            660                 665                 670         


Ile Cys Gly His Val Leu Ile Gly Pro His Lys Gln Arg Met Pro Glu 
        675                 680                 685             


Leu Gln Leu Ile Ala Asn Gly His Thr Lys Trp Leu Asn Lys Arg Lys 
    690                 695                 700                 


Ile Lys Ala Phe Tyr Ser Asp Val Ile Ala Glu Asp Leu Arg Arg Gly 
705                 710                 715                 720 


Val Gln Ile Leu Met Gln Ala Ala Gly Leu Gly Arg Met Lys Pro Asn 
                725                 730                 735     


Ile Leu Val Val Gly Phe Lys Lys Asn Trp Gln Ser Ala His Pro Ala 
            740                 745                 750         


Thr Val Glu Asp Tyr Ile Gly Ile Leu His Asp Ala Phe Asp Phe Asn 
        755                 760                 765             


Tyr Gly Val Cys Val Met Arg Met Arg Glu Gly Leu Asn Val Ser Lys 
    770                 775                 780                 


Met Met Gln Ala His Ile Asn Pro Val Phe Asp Pro Ala Glu Asp Gly 
785                 790                 795                 800 


Lys Glu Ala Ser Ala Arg Val Asp Pro Lys Ala Leu Val Lys Glu Glu 
                805                 810                 815     


Gln Ala Thr Thr Ile Phe Gln Ser Glu Gln Gly Lys Lys Thr Ile Asp 
            820                 825                 830         


Ile Tyr Trp Leu Phe Asp Asp Gly Gly Leu Thr Leu Leu Ile Pro Tyr 
        835                 840                 845             


Leu Leu Gly Arg Lys Arg Arg Trp Ser Lys Cys Lys Ile Arg Val Phe 
    850                 855                 860                 


Val Gly Gly Gln Ile Asn Arg Met Asp Gln Glu Arg Lys Ala Ile Ile 
865                 870                 875                 880 


Ser Leu Leu Ser Lys Phe Arg Leu Gly Phe His Glu Val His Ile Leu 
                885                 890                 895     


Pro Asp Ile Asn Gln Asn Pro Arg Ala Glu His Thr Lys Arg Phe Glu 
            900                 905                 910         


Asp Met Ile Ala Pro Phe Arg Leu Asn Asp Gly Phe Lys Asp Glu Ala 
        915                 920                 925             


Thr Val Asn Glu Met Arg Arg Asp Cys Pro Trp Lys Ile Ser Asp Glu 
    930                 935                 940                 


Glu Ile Thr Lys Asn Arg Val Lys Ser Leu Arg Gln Val Arg Leu Asn 
945                 950                 955                 960 


Glu Ile Val Leu Asp Tyr Ser Arg Asp Ala Ala Leu Ile Val Ile Thr 
                965                 970                 975     


Leu Pro Ile Gly Arg Lys Gly Lys Cys Pro Ser Ser Leu Tyr Met Ala 
            980                 985                 990         


Trp Leu Glu Thr Leu Ser Gln Asp  Leu Arg Pro Pro Val  Ile Leu Ile 
        995                 1000                 1005             


Arg Gly  Asn Gln Glu Asn Val  Leu Thr Phe Tyr Cys  Gln 
    1010                 1015                 1020     


<210>  1305
<211>  487
<212>  PRT
<213>  Homo sapiens

<400>  1305

Met Gly Asp Thr Gly Leu Arg Lys Arg Arg Glu Asp Glu Lys Ser Ile 
1               5                   10                  15      


Gln Ser Gln Glu Pro Lys Thr Thr Ser Leu Gln Lys Glu Leu Gly Leu 
            20                  25                  30          


Ile Ser Gly Ile Ser Ile Ile Val Gly Thr Ile Ile Gly Ser Gly Ile 
        35                  40                  45              


Phe Val Ser Pro Lys Ser Val Leu Ser Asn Thr Glu Ala Val Gly Pro 
    50                  55                  60                  


Cys Leu Ile Ile Trp Ala Ala Cys Gly Val Leu Ala Thr Leu Gly Ala 
65                  70                  75                  80  


Leu Cys Phe Ala Glu Leu Gly Thr Met Ile Thr Lys Ser Gly Gly Glu 
                85                  90                  95      


Tyr Pro Tyr Leu Met Glu Ala Tyr Gly Pro Ile Pro Ala Tyr Leu Phe 
            100                 105                 110         


Ser Trp Ala Ser Leu Ile Val Ile Lys Pro Thr Ser Phe Ala Ile Ile 
        115                 120                 125             


Cys Leu Ser Phe Ser Glu Tyr Val Cys Ala Pro Phe Tyr Val Gly Cys 
    130                 135                 140                 


Lys Pro Pro Gln Ile Val Val Lys Cys Leu Ala Ala Ala Ala Ile Leu 
145                 150                 155                 160 


Phe Ile Ser Thr Val Asn Ser Leu Ser Val Arg Leu Gly Ser Tyr Val 
                165                 170                 175     


Gln Asn Ile Phe Thr Ala Ala Lys Leu Val Ile Val Ala Ile Ile Ile 
            180                 185                 190         


Ile Ser Gly Leu Val Leu Leu Ala Gln Gly Asn Thr Lys Asn Phe Asp 
        195                 200                 205             


Asn Ser Phe Glu Gly Ala Gln Leu Ser Val Gly Ala Ile Ser Leu Ala 
    210                 215                 220                 


Phe Tyr Asn Gly Leu Trp Ala Tyr Asp Gly Trp Asn Gln Leu Asn Tyr 
225                 230                 235                 240 


Ile Thr Glu Glu Leu Arg Asn Pro Tyr Arg Asn Leu Pro Leu Ala Ile 
                245                 250                 255     


Ile Ile Gly Ile Pro Leu Val Thr Ala Cys Tyr Ile Leu Met Asn Val 
            260                 265                 270         


Ser Tyr Phe Thr Val Met Thr Ala Thr Glu Leu Leu Gln Ser Gln Ala 
        275                 280                 285             


Val Ala Val Thr Phe Gly Asp Arg Val Leu Tyr Pro Ala Ser Trp Ile 
    290                 295                 300                 


Val Pro Leu Phe Val Ala Phe Ser Thr Ile Gly Ala Ala Asn Gly Thr 
305                 310                 315                 320 


Cys Phe Thr Ala Gly Arg Leu Ile Tyr Val Ala Gly Arg Glu Gly His 
                325                 330                 335     


Met Leu Lys Val Leu Ser Tyr Ile Ser Val Arg Arg Leu Thr Pro Ala 
            340                 345                 350         


Pro Ala Ile Ile Phe Tyr Gly Ile Ile Ala Thr Ile Tyr Ile Ile Pro 
        355                 360                 365             


Gly Asp Ile Asn Ser Leu Val Asn Tyr Phe Ser Phe Ala Ala Trp Leu 
    370                 375                 380                 


Phe Tyr Gly Leu Thr Ile Leu Gly Leu Ile Val Met Arg Phe Thr Arg 
385                 390                 395                 400 


Lys Glu Leu Glu Arg Pro Ile Lys Val Pro Val Val Ile Pro Val Leu 
                405                 410                 415     


Met Thr Leu Ile Ser Val Phe Leu Val Leu Ala Pro Ile Ile Ser Lys 
            420                 425                 430         


Pro Thr Trp Glu Tyr Leu Tyr Cys Val Leu Phe Ile Leu Ser Gly Leu 
        435                 440                 445             


Leu Phe Tyr Phe Leu Phe Val His Tyr Lys Phe Gly Trp Ala Gln Lys 
    450                 455                 460                 


Ile Ser Lys Pro Ile Thr Met His Leu Gln Met Leu Met Glu Val Val 
465                 470                 475                 480 


Pro Pro Glu Glu Asp Pro Glu 
                485         


<210>  1306
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  1306

Met Ser Ala Glu Leu Asn Val Pro Ile Asp Pro Ser Ala Pro Ala Cys 
1               5                   10                  15      


Pro Glu Pro Gly His Lys Gly Met Asp Tyr Arg Asp Trp Val Arg Arg 
            20                  25                  30          


Ser Tyr Leu Glu Leu Val Thr Ser Asn His His Ser Val Gln Ala Leu 
        35                  40                  45              


Ser Trp Arg Lys Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser 
    50                  55                  60                  


Arg Thr Ser Ala Leu Leu Ser Gly Phe Ala Met Val Ala Met Val Glu 
65                  70                  75                  80  


Val Gln Leu Glu Thr Gln Tyr Gln Tyr Pro Arg Pro Leu Leu Ile Ala 
                85                  90                  95      


Phe Ser Ala Cys Thr Thr Val Leu Val Ala Val His Leu Phe Ala Leu 
            100                 105                 110         


Leu Ile Ser Thr Cys Ile Leu Pro Asn Val Glu Ala Val Ser Asn Ile 
        115                 120                 125             


His Asn Leu Asn Ser Ile Ser Glu Ser Pro His Glu Arg Met His Pro 
    130                 135                 140                 


Tyr Ile Glu Leu Ala Trp Gly Phe Ser Thr Val Leu Gly Ile Leu Leu 
145                 150                 155                 160 


Phe Leu Ala Glu Val Val Leu Leu Cys Trp Ile Lys Phe Leu Pro Val 
                165                 170                 175     


Asp Ala Arg Arg Gln Pro Gly Pro Pro Pro Gly Pro Gly Ser His Thr 
            180                 185                 190         


Gly Trp Gln Ala Ala Leu Val Ser Thr Ile Ile Met Val Pro Val Gly 
        195                 200                 205             


Leu Ile Phe Val Val Phe Thr Ile His Phe Tyr Arg Ser Leu Val Arg 
    210                 215                 220                 


His Lys Thr Glu Arg His Asn Arg Glu Ile Glu Glu Leu His Lys Leu 
225                 230                 235                 240 


Lys Val Gln Leu Asp Gly His Glu Arg Ser Leu Gln Val Leu 
                245                 250                 


<210>  1307
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  1307

Met Gly Ala Pro Ala Ala Ser Leu Leu Leu Leu Leu Leu Leu Phe Ala 
1               5                   10                  15      


Cys Cys Trp Ala Pro Gly Gly Ala Asn Leu Ser Gln Asp Asp Ser Gln 
            20                  25                  30          


Pro Trp Thr Ser Asp Glu Thr Val Val Ala Gly Gly Thr Val Val Leu 
        35                  40                  45              


Lys Cys Gln Val Lys Asp His Glu Asp Ser Ser Leu Gln Trp Ser Asn 
    50                  55                  60                  


Pro Ala Gln Gln Thr Leu Tyr Phe Gly Glu Lys Arg Ala Leu Arg Asp 
65                  70                  75                  80  


Asn Arg Ile Gln Leu Val Thr Ser Thr Pro His Glu Leu Ser Ile Ser 
                85                  90                  95      


Ile Ser Asn Val Ala Leu Ala Asp Glu Gly Glu Tyr Thr Cys Ser Ile 
            100                 105                 110         


Phe Thr Met Pro Val Arg Thr Ala Lys Ser Leu Val Thr Val Leu Gly 
        115                 120                 125             


Ile Pro Gln Lys Pro Ile Ile Thr Gly Tyr Lys Ser Ser Leu Arg Glu 
    130                 135                 140                 


Lys Asp Thr Ala Thr Leu Asn Cys Gln Ser Ser Gly Ser Lys Pro Ala 
145                 150                 155                 160 


Ala Arg Leu Thr Trp Arg Lys Gly Asp Gln Glu Leu His Gly Glu Pro 
                165                 170                 175     


Thr Arg Ile Gln Glu Asp Pro Asn Gly Lys Thr Phe Thr Val Ser Ser 
            180                 185                 190         


Ser Val Thr Phe Gln Val Thr Arg Glu Asp Asp Gly Ala Ser Ile Val 
        195                 200                 205             


Cys Ser Val Asn His Glu Ser Leu Lys Gly Ala Asp Arg Ser Thr Ser 
    210                 215                 220                 


Gln Arg Ile Glu Val Leu Tyr Thr Pro Thr Ala Met Ile Arg Pro Asp 
225                 230                 235                 240 


Pro Pro His Pro Arg Glu Gly Gln Lys Leu Leu Leu His Cys Glu Gly 
                245                 250                 255     


Arg Gly Asn Pro Val Pro Gln Gln Tyr Leu Trp Glu Lys Glu Gly Ser 
            260                 265                 270         


Val Pro Pro Leu Lys Met Thr Gln Glu Ser Ala Leu Ile Phe Pro Phe 
        275                 280                 285             


Leu Asn Lys Ser Asp Ser Gly Thr Tyr Gly Cys Thr Ala Thr Ser Asn 
    290                 295                 300                 


Met Gly Ser Tyr Lys Ala Tyr Tyr Thr Leu Asn Val Asn Asp Pro Ser 
305                 310                 315                 320 


Pro Val Pro Ser Ser Ser Ser Thr Tyr His Ala Ile Ile Gly Gly Ile 
                325                 330                 335     


Val Ala Phe Ile Val Phe Leu Leu Leu Ile Met Leu Ile Phe Leu Gly 
            340                 345                 350         


His Tyr Leu Ile Arg His Lys Gly Thr Tyr Leu Thr His Glu Ala Lys 
        355                 360                 365             


Gly Ser Asp Asp Ala Pro Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu 
    370                 375                 380                 


Gly Gly Gln Ser Gly Gly Asp Asp Lys Lys Glu Tyr Phe Ile 
385                 390                 395             


<210>  1308
<211>  983
<212>  PRT
<213>  Homo sapiens

<400>  1308

Met Arg Leu Gly Ser Gly Thr Phe Ala Thr Cys Cys Val Ala Ile Glu 
1               5                   10                  15      


Val Leu Gly Ile Ala Val Phe Leu Arg Gly Phe Phe Pro Ala Pro Val 
            20                  25                  30          


Arg Ser Ser Ala Arg Ala Glu His Gly Ala Glu Pro Pro Ala Pro Glu 
        35                  40                  45              


Pro Ser Ala Gly Ala Ser Ser Asn Trp Thr Thr Leu Pro Pro Pro Leu 
    50                  55                  60                  


Phe Ser Lys Val Val Ile Val Leu Ile Asp Ala Leu Arg Asp Asp Phe 
65                  70                  75                  80  


Val Phe Gly Ser Lys Gly Val Lys Phe Met Pro Tyr Thr Thr Tyr Leu 
                85                  90                  95      


Val Glu Lys Gly Ala Ser His Ser Phe Val Ala Glu Ala Lys Pro Pro 
            100                 105                 110         


Thr Val Thr Met Pro Arg Ile Lys Ala Leu Met Thr Gly Ser Leu Pro 
        115                 120                 125             


Gly Phe Val Asp Val Ile Arg Asn Leu Asn Ser Pro Ala Leu Leu Glu 
    130                 135                 140                 


Asp Ser Val Ile Arg Gln Ala Lys Ala Ala Gly Lys Arg Ile Val Phe 
145                 150                 155                 160 


Tyr Gly Asp Glu Thr Trp Val Lys Leu Phe Pro Lys His Phe Val Glu 
                165                 170                 175     


Tyr Asp Gly Thr Thr Ser Phe Phe Val Ser Asp Tyr Thr Glu Val Asp 
            180                 185                 190         


Asn Asn Val Thr Arg His Leu Asp Lys Val Leu Lys Arg Gly Asp Trp 
        195                 200                 205             


Asp Ile Leu Ile Leu His Tyr Leu Gly Leu Asp His Ile Gly His Ile 
    210                 215                 220                 


Ser Gly Pro Asn Ser Pro Leu Ile Gly Gln Lys Leu Ser Glu Met Asp 
225                 230                 235                 240 


Ser Val Leu Met Lys Ile His Thr Ser Leu Gln Ser Lys Glu Arg Glu 
                245                 250                 255     


Thr Pro Leu Pro Asn Leu Leu Val Leu Cys Gly Asp His Gly Met Ser 
            260                 265                 270         


Glu Thr Gly Ser His Gly Ala Ser Ser Thr Glu Glu Val Asn Thr Pro 
        275                 280                 285             


Leu Ile Leu Ile Ser Ser Ala Phe Glu Arg Lys Pro Gly Asp Ile Arg 
    290                 295                 300                 


His Pro Lys His Val Gln Gln Thr Asp Val Ala Ala Thr Leu Ala Ile 
305                 310                 315                 320 


Ala Leu Gly Leu Pro Ile Pro Lys Asp Ser Val Gly Ser Leu Leu Phe 
                325                 330                 335     


Pro Val Val Glu Gly Arg Pro Met Arg Glu Gln Leu Arg Phe Leu His 
            340                 345                 350         


Leu Asn Thr Val Gln Leu Ser Lys Leu Leu Gln Glu Asn Val Pro Ser 
        355                 360                 365             


Tyr Glu Lys Asp Pro Gly Phe Glu Gln Phe Lys Met Ser Glu Arg Leu 
    370                 375                 380                 


His Gly Asn Trp Ile Arg Leu Tyr Leu Glu Glu Lys His Ser Glu Val 
385                 390                 395                 400 


Leu Phe Asn Leu Gly Ser Lys Val Leu Arg Gln Tyr Leu Asp Ala Leu 
                405                 410                 415     


Lys Thr Leu Ser Leu Ser Leu Ser Ala Gln Val Ala Gln Tyr Asp Ile 
            420                 425                 430         


Tyr Ser Met Met Val Gly Thr Val Val Val Leu Glu Val Leu Thr Leu 
        435                 440                 445             


Leu Leu Leu Ser Val Pro Gln Ala Leu Arg Arg Lys Ala Glu Leu Glu 
    450                 455                 460                 


Val Pro Leu Ser Ser Pro Gly Phe Ser Leu Leu Phe Tyr Leu Val Ile 
465                 470                 475                 480 


Leu Val Leu Ser Ala Val His Val Ile Val Cys Thr Ser Ala Glu Ser 
                485                 490                 495     


Ser Cys Tyr Phe Cys Gly Leu Ser Trp Leu Ala Ala Gly Gly Val Met 
            500                 505                 510         


Val Leu Ala Ser Ala Leu Leu Cys Val Ile Val Ser Val Leu Thr Asn 
        515                 520                 525             


Val Leu Val Gly Gly Asn Thr Pro Arg Lys Asn Pro Met His Pro Ser 
    530                 535                 540                 


Ser Arg Trp Ser Glu Leu Asp Leu Leu Ile Leu Leu Gly Thr Ala Gly 
545                 550                 555                 560 


His Val Leu Ser Leu Gly Ala Ser Ser Phe Val Glu Glu Glu His Gln 
                565                 570                 575     


Thr Trp Tyr Phe Leu Val Asn Thr Leu Cys Leu Ala Leu Ser Gln Glu 
            580                 585                 590         


Thr Tyr Arg Asn Tyr Phe Leu Gly Asp Asp Gly Glu Pro Pro Cys Gly 
        595                 600                 605             


Leu Cys Val Glu Gln Gly His Asp Gly Ala Thr Ala Ala Trp Gln Asp 
    610                 615                 620                 


Gly Pro Gly Cys Asp Val Leu Glu Arg Asp Lys Gly His Gly Ser Pro 
625                 630                 635                 640 


Ser Thr Ser Glu Val Leu Arg Gly Arg Glu Lys Trp Met Val Leu Ala 
                645                 650                 655     


Ser Pro Trp Leu Ile Leu Ala Cys Cys Arg Leu Leu Arg Ser Leu Asn 
            660                 665                 670         


Gln Thr Gly Val Gln Trp Ala His Arg Pro Asp Leu Gly His Trp Leu 
        675                 680                 685             


Thr Ser Ser Asp His Lys Ala Glu Leu Ser Val Leu Ala Ala Leu Ser 
    690                 695                 700                 


Leu Leu Val Val Phe Val Leu Val Gln Arg Gly Cys Ser Pro Val Ser 
705                 710                 715                 720 


Lys Ala Ala Leu Ala Leu Gly Leu Leu Gly Val Tyr Cys Tyr Arg Ala 
                725                 730                 735     


Ala Ile Gly Ser Val Arg Phe Pro Trp Arg Pro Asp Ser Lys Asp Ile 
            740                 745                 750         


Ser Lys Gly Ile Ile Glu Ala Arg Phe Val Tyr Val Phe Val Leu Gly 
        755                 760                 765             


Ile Leu Phe Thr Gly Thr Lys Asp Leu Leu Lys Ser Gln Val Ile Ala 
    770                 775                 780                 


Ala Asp Phe Lys Leu Lys Thr Val Gly Leu Trp Glu Ile Tyr Ser Gly 
785                 790                 795                 800 


Leu Val Leu Leu Ala Ala Leu Leu Phe Arg Pro His Asn Leu Pro Val 
                805                 810                 815     


Leu Ala Phe Ser Leu Leu Ile Gln Thr Leu Met Thr Lys Phe Ile Trp 
            820                 825                 830         


Lys Pro Leu Arg His Asp Ala Ala Glu Ile Thr Val Met His Tyr Trp 
        835                 840                 845             


Phe Gly Gln Ala Phe Phe Tyr Phe Gln Gly Asn Ser Asn Asn Ile Ala 
    850                 855                 860                 


Thr Val Asp Ile Ser Ala Gly Phe Val Gly Leu Asp Thr Tyr Val Glu 
865                 870                 875                 880 


Ile Pro Ala Val Leu Leu Thr Ala Phe Gly Thr Tyr Ala Gly Pro Val 
                885                 890                 895     


Leu Trp Ala Ser His Leu Val His Phe Leu Ser Ser Glu Thr Arg Ser 
            900                 905                 910         


Gly Ser Ala Leu Ser His Ala Cys Phe Cys Tyr Ala Leu Ile Cys Ser 
        915                 920                 925             


Ile Pro Val Phe Thr Tyr Ile Val Leu Val Thr Ser Leu Arg Tyr His 
    930                 935                 940                 


Leu Phe Ile Trp Ser Val Phe Ser Pro Lys Leu Leu Tyr Glu Gly Met 
945                 950                 955                 960 


His Leu Leu Ile Thr Ala Ala Val Cys Val Phe Phe Thr Ala Met Asp 
                965                 970                 975     


Gln Thr Arg Leu Thr Gln Ser 
            980             


<210>  1309
<211>  805
<212>  PRT
<213>  Homo sapiens

<400>  1309

Met Ala Gln Pro Leu Ala Phe Ile Leu Asp Val Pro Glu Thr Pro Gly 
1               5                   10                  15      


Asp Gln Gly Gln Gly Pro Ser Pro Tyr Asp Glu Ser Glu Val His Asp 
            20                  25                  30          


Ser Phe Gln Gln Leu Ile Gln Glu Gln Ser Gln Cys Thr Ala Gln Glu 
        35                  40                  45              


Gly Leu Glu Leu Gln Gln Arg Glu Arg Glu Val Thr Gly Ser Ser Gln 
    50                  55                  60                  


Gln Thr Leu Trp Arg Pro Glu Gly Thr Gln Ser Thr Ala Thr Leu Arg 
65                  70                  75                  80  


Ile Leu Ala Ser Met Pro Ser Arg Thr Ile Gly Arg Ser Arg Gly Ala 
                85                  90                  95      


Ile Ile Ser Gln Tyr Tyr Asn Arg Thr Val Gln Leu Arg Cys Arg Ser 
            100                 105                 110         


Ser Arg Pro Leu Leu Gly Asn Phe Val Arg Ser Ala Trp Pro Ser Leu 
        115                 120                 125             


Arg Leu Tyr Asp Leu Glu Leu Asp Pro Thr Ala Leu Glu Glu Glu Glu 
    130                 135                 140                 


Lys Gln Ser Leu Leu Val Lys Glu Leu Gln Ser Leu Ala Val Ala Gln 
145                 150                 155                 160 


Arg Asp His Met Leu Arg Gly Met Pro Leu Ser Leu Ala Glu Lys Arg 
                165                 170                 175     


Ser Leu Arg Glu Lys Ser Arg Thr Pro Arg Gly Lys Trp Arg Gly Gln 
            180                 185                 190         


Pro Gly Ser Gly Gly Val Cys Ser Cys Cys Gly Arg Leu Arg Tyr Ala 
        195                 200                 205             


Cys Val Leu Ala Leu His Ser Leu Gly Leu Ala Leu Leu Ser Ala Leu 
    210                 215                 220                 


Gln Ala Leu Met Pro Trp Arg Tyr Ala Leu Lys Arg Ile Gly Gly Gln 
225                 230                 235                 240 


Phe Gly Ser Ser Val Leu Ser Tyr Phe Leu Phe Leu Lys Thr Leu Leu 
                245                 250                 255     


Ala Phe Asn Ala Leu Leu Leu Leu Leu Leu Val Ala Phe Ile Met Gly 
            260                 265                 270         


Pro Gln Val Ala Phe Pro Pro Ala Leu Pro Gly Pro Ala Pro Val Cys 
        275                 280                 285             


Thr Gly Leu Glu Leu Leu Thr Gly Ala Gly Cys Phe Thr His Thr Val 
    290                 295                 300                 


Met Tyr Tyr Gly His Tyr Ser Asn Ala Thr Leu Asn Gln Pro Cys Gly 
305                 310                 315                 320 


Ser Pro Leu Asp Gly Ser Gln Cys Thr Pro Arg Val Gly Gly Leu Pro 
                325                 330                 335     


Tyr Asn Met Pro Leu Ala Tyr Leu Ser Thr Val Gly Val Ser Phe Phe 
            340                 345                 350         


Ile Thr Cys Ile Thr Leu Val Tyr Ser Met Ala His Ser Phe Gly Glu 
        355                 360                 365             


Ser Tyr Arg Val Gly Ser Thr Ser Gly Ile His Ala Ile Thr Val Phe 
    370                 375                 380                 


Cys Ser Trp Asp Tyr Lys Val Thr Gln Lys Arg Ala Ser Arg Leu Gln 
385                 390                 395                 400 


Gln Asp Asn Ile Arg Thr Arg Leu Lys Glu Leu Leu Ala Glu Trp Gln 
                405                 410                 415     


Leu Arg His Ser Pro Arg Ser Val Cys Gly Arg Leu Arg Gln Ala Ala 
            420                 425                 430         


Val Leu Gly Leu Val Trp Leu Leu Cys Leu Gly Thr Ala Leu Gly Cys 
        435                 440                 445             


Ala Val Ala Val His Val Phe Ser Glu Phe Met Ile Gln Ser Pro Glu 
    450                 455                 460                 


Ala Ala Gly Gln Glu Ala Val Leu Leu Val Leu Pro Leu Val Val Gly 
465                 470                 475                 480 


Leu Leu Asn Leu Gly Ala Pro Tyr Leu Cys Arg Val Leu Ala Ala Leu 
                485                 490                 495     


Glu Pro His Asp Ser Pro Val Leu Glu Val Tyr Val Ala Ile Cys Arg 
            500                 505                 510         


Asn Leu Ile Leu Lys Leu Ala Ile Leu Gly Thr Leu Cys Tyr His Trp 
        515                 520                 525             


Leu Gly Arg Arg Val Gly Val Leu Gln Gly Gln Cys Trp Glu Asp Phe 
    530                 535                 540                 


Val Gly Gln Glu Leu Tyr Arg Phe Leu Val Met Asp Phe Val Leu Met 
545                 550                 555                 560 


Leu Leu Asp Thr Leu Phe Gly Glu Leu Val Trp Arg Ile Ile Ser Glu 
                565                 570                 575     


Lys Lys Leu Lys Arg Arg Arg Lys Pro Glu Phe Asp Ile Ala Arg Asn 
            580                 585                 590         


Val Leu Glu Leu Ile Tyr Gly Gln Thr Leu Thr Trp Leu Gly Val Leu 
        595                 600                 605             


Phe Ser Pro Leu Leu Pro Ala Val Gln Ile Ile Lys Leu Leu Leu Val 
    610                 615                 620                 


Phe Tyr Val Lys Lys Thr Ser Leu Leu Ala Asn Cys Gln Ala Pro Arg 
625                 630                 635                 640 


Arg Pro Trp Leu Ala Ser His Met Ser Thr Val Phe Leu Thr Leu Leu 
                645                 650                 655     


Cys Phe Pro Ala Phe Leu Gly Ala Ala Val Phe Leu Cys Tyr Ala Val 
            660                 665                 670         


Trp Gln Val Lys Pro Ser Ser Thr Cys Gly Pro Phe Arg Thr Leu Asp 
        675                 680                 685             


Thr Met Tyr Glu Ala Gly Arg Val Trp Val Arg His Leu Glu Ala Ala 
    690                 695                 700                 


Gly Pro Arg Val Ser Trp Leu Pro Trp Val His Arg Tyr Leu Met Glu 
705                 710                 715                 720 


Asn Thr Phe Phe Val Phe Leu Val Ser Ala Leu Leu Leu Ala Val Ile 
                725                 730                 735     


Tyr Leu Asn Ile Gln Val Val Arg Gly Gln Arg Lys Val Ile Cys Leu 
            740                 745                 750         


Leu Lys Glu Gln Ile Ser Asn Glu Gly Glu Asp Lys Ile Phe Leu Ile 
        755                 760                 765             


Asn Lys Leu His Ser Ile Tyr Glu Arg Lys Glu Arg Glu Glu Arg Ser 
    770                 775                 780                 


Arg Val Gly Thr Thr Glu Glu Ala Ala Ala Pro Pro Ala Leu Leu Thr 
785                 790                 795                 800 


Asp Glu Gln Asp Ala 
                805 


<210>  1310
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  1310

Met Ser Ala Glu Val Glu Thr Ser Glu Gly Val Asp Glu Ser Glu Lys 
1               5                   10                  15      


Lys Asn Ser Gly Ala Leu Glu Lys Glu Asn Gln Met Arg Met Ala Asp 
            20                  25                  30          


Leu Ser Glu Leu Leu Lys Glu Gly Thr Lys Glu Ala His Asp Arg Ala 
        35                  40                  45              


Glu Asn Thr Gln Phe Val Lys Asp Phe Leu Lys Gly Asn Ile Lys Lys 
    50                  55                  60                  


Glu Leu Phe Lys Leu Ala Thr Thr Ala Leu Tyr Phe Thr Tyr Ser Ala 
65                  70                  75                  80  


Leu Glu Glu Glu Met Glu Arg Asn Lys Asp His Pro Ala Phe Ala Pro 
                85                  90                  95      


Leu Tyr Phe Pro Met Glu Leu His Arg Lys Glu Ala Leu Thr Lys Asp 
            100                 105                 110         


Met Glu Tyr Phe Phe Gly Glu Asn Trp Glu Glu Gln Val Gln Cys Pro 
        115                 120                 125             


Lys Ala Ala Gln Lys Tyr Val Glu Arg Ile His Tyr Ile Gly Gln Asn 
    130                 135                 140                 


Glu Pro Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Met Gly Asp 
145                 150                 155                 160 


Leu Ser Gly Gly Gln Val Leu Lys Lys Val Ala Gln Arg Ala Leu Lys 
                165                 170                 175     


Leu Pro Ser Thr Gly Glu Gly Thr Gln Phe Tyr Leu Phe Glu Asn Val 
            180                 185                 190         


Asp Asn Ala Gln Gln Phe Lys Gln Leu Tyr Arg Ala Arg Met Asn Ala 
        195                 200                 205             


Leu Asp Leu Asn Met Lys Thr Lys Glu Arg Ile Val Glu Glu Ala Asn 
    210                 215                 220                 


Lys Ala Phe Glu Tyr Asn Met Gln Ile Phe Asn Glu Leu Asp Gln Ala 
225                 230                 235                 240 


Gly Ser Thr Leu Ala Arg Glu Thr Leu Glu Asp Gly Phe Pro Val His 
                245                 250                 255     


Asp Gly Lys Gly Asp Met Arg Lys Cys Pro Phe Tyr Ala Ala Glu Gln 
            260                 265                 270         


Asp Lys Gly Ala Leu Glu Gly Ser Ser Cys Pro Phe Arg Thr Ala Met 
        275                 280                 285             


Ala Val Leu Arg Lys Pro Ser Leu Gln Phe Ile Leu Ala Ala Gly Val 
    290                 295                 300                 


Ala Leu Ala Ala Gly Leu Leu Ala Trp Tyr Tyr Met 
305                 310                 315     


<210>  1311
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  1311

Met Ser Ala Glu Val Glu Thr Ser Glu Gly Val Asp Glu Ser Glu Lys 
1               5                   10                  15      


Lys Asn Ser Gly Ala Leu Glu Lys Glu Asn Gln Met Arg Met Ala Asp 
            20                  25                  30          


Leu Ser Glu Leu Leu Lys Glu Gly Thr Lys Glu Ala His Asp Arg Ala 
        35                  40                  45              


Glu Asn Thr Gln Phe Val Lys Asp Phe Leu Lys Gly Asn Ile Lys Lys 
    50                  55                  60                  


Glu Leu Phe Lys Leu Ala Thr Thr Ala Leu Tyr Phe Thr Tyr Ser Ala 
65                  70                  75                  80  


Leu Glu Glu Glu Met Glu Arg Asn Lys Asp His Pro Ala Phe Ala Pro 
                85                  90                  95      


Leu Tyr Phe Pro Met Glu Leu His Arg Lys Glu Ala Leu Thr Lys Asp 
            100                 105                 110         


Met Glu Tyr Phe Phe Gly Glu Asn Trp Glu Glu Gln Val Gln Cys Pro 
        115                 120                 125             


Lys Ala Ala Gln Lys Tyr Val Glu Arg Ile His Tyr Ile Gly Gln Asn 
    130                 135                 140                 


Glu Pro Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Met Gly Asp 
145                 150                 155                 160 


Leu Ser Gly Gly Gln Val Leu Lys Lys Val Ala Gln Arg Ala Leu Lys 
                165                 170                 175     


Leu Pro Ser Thr Gly Glu Gly Thr Gln Phe Tyr Leu Phe Glu Asn Val 
            180                 185                 190         


Asp Asn Ala Gln Gln Phe Lys Gln Leu Tyr Arg Ala Arg Met Asn Ala 
        195                 200                 205             


Leu Asp Leu Asn Met Lys Thr Lys Glu Arg Ile Val Glu Glu Ala Asn 
    210                 215                 220                 


Lys Ala Phe Glu Tyr Asn Met Gln Ile Phe Asn Glu Leu Asp Gln Ala 
225                 230                 235                 240 


Gly Ser Thr Leu Ala Arg Glu Thr Leu Glu Asp Gly Phe Pro Val His 
                245                 250                 255     


Asp Gly Lys Gly Asp Met Arg Lys Cys Pro Phe Tyr Ala Ala Glu Gln 
            260                 265                 270         


Asp Lys Gly Ala Leu Glu Gly Ser Ser Cys Pro Phe Arg Thr Ala Met 
        275                 280                 285             


Ala Val Leu Arg Lys Pro Ser Leu Gln Phe Ile Leu Ala Ala Gly Val 
    290                 295                 300                 


Ala Leu Ala Ala Gly Leu Leu Ala Trp Tyr Tyr Met 
305                 310                 315     


<210>  1312
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  1312

Met Ser Ala Glu Val Glu Thr Ser Glu Gly Val Asp Glu Ser Glu Lys 
1               5                   10                  15      


Lys Asn Ser Gly Ala Leu Glu Lys Glu Asn Gln Met Arg Met Ala Asp 
            20                  25                  30          


Leu Ser Glu Leu Leu Lys Glu Gly Thr Lys Glu Ala His Asp Arg Ala 
        35                  40                  45              


Glu Asn Thr Gln Phe Val Lys Asp Phe Leu Lys Gly Asn Ile Lys Lys 
    50                  55                  60                  


Glu Leu Phe Lys Leu Ala Thr Thr Ala Leu Tyr Phe Thr Tyr Ser Ala 
65                  70                  75                  80  


Leu Glu Glu Glu Met Glu Arg Asn Lys Asp His Pro Ala Phe Ala Pro 
                85                  90                  95      


Leu Tyr Phe Pro Met Glu Leu His Arg Lys Glu Ala Leu Thr Lys Asp 
            100                 105                 110         


Met Glu Tyr Phe Phe Gly Glu Asn Trp Glu Glu Gln Val Gln Cys Pro 
        115                 120                 125             


Lys Ala Ala Gln Lys Tyr Val Glu Arg Ile His Tyr Ile Gly Gln Asn 
    130                 135                 140                 


Glu Pro Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Met Gly Asp 
145                 150                 155                 160 


Leu Ser Gly Gly Gln Val Leu Lys Lys Val Ala Gln Arg Ala Leu Lys 
                165                 170                 175     


Leu Pro Ser Thr Gly Glu Gly Thr Gln Phe Tyr Leu Phe Glu Asn Val 
            180                 185                 190         


Asp Asn Ala Gln Gln Phe Lys Gln Leu Tyr Arg Ala Arg Met Asn Ala 
        195                 200                 205             


Leu Asp Leu Asn Met Lys Thr Lys Glu Arg Ile Val Glu Glu Ala Asn 
    210                 215                 220                 


Lys Ala Phe Glu Tyr Asn Met Gln Ile Phe Asn Glu Leu Asp Gln Ala 
225                 230                 235                 240 


Gly Ser Thr Leu Ala Arg Glu Thr Leu Glu Asp Gly Phe Pro Val His 
                245                 250                 255     


Asp Gly Lys Gly Asp Met Arg Lys Cys Pro Phe Tyr Ala Ala Glu Gln 
            260                 265                 270         


Asp Lys Gly Ala Leu Glu Gly Ser Ser Cys Pro Phe Arg Thr Ala Met 
        275                 280                 285             


Ala Val Leu Arg Lys Pro Ser Leu Gln Phe Ile Leu Ala Ala Gly Val 
    290                 295                 300                 


Ala Leu Ala Ala Gly Leu Leu Ala Trp Tyr Tyr Met 
305                 310                 315     


<210>  1313
<211>  2261
<212>  PRT
<213>  Homo sapiens

<400>  1313

Met Ala Arg Phe Gly Asp Glu Met Pro Ala Arg Tyr Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Ala Ala Ala Gly Val Val Val Gly Ser Gly Gly Gly Arg Gly 
            20                  25                  30          


Ala Gly Gly Ser Arg Gln Gly Gly Gln Pro Gly Ala Gln Arg Met Tyr 
        35                  40                  45              


Lys Gln Ser Met Ala Gln Arg Ala Arg Thr Met Ala Leu Tyr Asn Pro 
    50                  55                  60                  


Ile Pro Val Arg Gln Asn Cys Leu Thr Val Asn Arg Ser Leu Phe Leu 
65                  70                  75                  80  


Phe Ser Glu Asp Asn Val Val Arg Lys Tyr Ala Lys Lys Ile Thr Glu 
                85                  90                  95      


Trp Pro Pro Phe Glu Tyr Met Ile Leu Ala Thr Ile Ile Ala Asn Cys 
            100                 105                 110         


Ile Val Leu Ala Leu Glu Gln His Leu Pro Asp Asp Asp Lys Thr Pro 
        115                 120                 125             


Met Ser Glu Arg Leu Asp Asp Thr Glu Pro Tyr Phe Ile Gly Ile Phe 
    130                 135                 140                 


Cys Phe Glu Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Ala Phe His 
145                 150                 155                 160 


Lys Gly Ser Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val Val 
                165                 170                 175     


Val Leu Thr Gly Ile Leu Ala Thr Val Gly Thr Glu Phe Asp Leu Arg 
            180                 185                 190         


Thr Leu Arg Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly 
        195                 200                 205             


Ile Pro Ser Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met Ile 
    210                 215                 220                 


Pro Leu Leu Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Ile Phe 
225                 230                 235                 240 


Ala Ile Ile Gly Leu Glu Phe Tyr Met Gly Lys Phe His Thr Thr Cys 
                245                 250                 255     


Phe Glu Glu Gly Thr Asp Asp Ile Gln Gly Glu Ser Pro Ala Pro Cys 
            260                 265                 270         


Gly Thr Glu Glu Pro Ala Arg Thr Cys Pro Asn Gly Thr Lys Cys Gln 
        275                 280                 285             


Pro Tyr Trp Glu Gly Pro Asn Asn Gly Ile Thr Gln Phe Asp Asn Ile 
    290                 295                 300                 


Leu Phe Ala Val Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp 
305                 310                 315                 320 


Thr Asp Leu Leu Tyr Asn Ser Asn Asp Ala Ser Gly Asn Thr Trp Asn 
                325                 330                 335     


Trp Leu Tyr Phe Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met Leu 
            340                 345                 350         


Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg Glu 
        355                 360                 365             


Arg Val Glu Asn Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln Gln 
    370                 375                 380                 


Ile Glu Arg Glu Leu Asn Gly Tyr Met Glu Trp Ile Ser Lys Ala Glu 
385                 390                 395                 400 


Glu Val Ile Leu Ala Glu Asp Glu Thr Asp Gly Glu Gln Arg His Pro 
                405                 410                 415     


Phe Asp Gly Ala Leu Arg Arg Thr Thr Ile Lys Lys Ser Lys Thr Asp 
            420                 425                 430         


Leu Leu Asn Pro Glu Glu Ala Glu Asp Gln Leu Ala Asp Ile Ala Ser 
        435                 440                 445             


Val Gly Ser Pro Phe Ala Arg Ala Ser Ile Lys Ser Ala Lys Leu Glu 
    450                 455                 460                 


Asn Ser Thr Phe Phe His Lys Lys Glu Arg Arg Met Arg Phe Tyr Ile 
465                 470                 475                 480 


Arg Arg Met Val Lys Thr Gln Ala Phe Tyr Trp Thr Val Leu Ser Leu 
                485                 490                 495     


Val Ala Leu Asn Thr Leu Cys Val Ala Ile Val His Tyr Asn Gln Pro 
            500                 505                 510         


Glu Trp Leu Ser Asp Phe Leu Tyr Tyr Ala Glu Phe Ile Phe Leu Gly 
        515                 520                 525             


Leu Phe Met Ser Glu Met Phe Ile Lys Met Tyr Gly Leu Gly Thr Arg 
    530                 535                 540                 


Pro Tyr Phe His Ser Ser Phe Asn Cys Phe Asp Cys Gly Val Ile Ile 
545                 550                 555                 560 


Gly Ser Ile Phe Glu Val Ile Trp Ala Val Ile Lys Pro Gly Thr Ser 
                565                 570                 575     


Phe Gly Ile Ser Val Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys 
            580                 585                 590         


Val Thr Lys Tyr Trp Ala Ser Leu Arg Asn Leu Val Val Ser Leu Leu 
        595                 600                 605             


Asn Ser Met Lys Ser Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu Phe 
    610                 615                 620                 


Ile Val Val Phe Ala Leu Leu Gly Met Gln Leu Phe Gly Gly Gln Phe 
625                 630                 635                 640 


Asn Phe Asp Glu Gly Thr Pro Pro Thr Asn Phe Asp Thr Phe Pro Ala 
                645                 650                 655     


Ala Ile Met Thr Val Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Glu 
            660                 665                 670         


Val Met Tyr Asp Gly Ile Lys Ser Gln Gly Gly Val Gln Gly Gly Met 
        675                 680                 685             


Val Phe Ser Ile Tyr Phe Ile Val Leu Thr Leu Phe Gly Asn Tyr Thr 
    690                 695                 700                 


Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asn Ala 
705                 710                 715                 720 


Gln Glu Leu Thr Lys Asp Glu Gln Glu Glu Glu Glu Ala Ala Asn Gln 
                725                 730                 735     


Lys Leu Ala Leu Gln Lys Ala Lys Glu Val Ala Glu Val Ser Pro Leu 
            740                 745                 750         


Ser Ala Ala Asn Met Ser Ile Ala Val Lys Glu Gln Gln Lys Asn Gln 
        755                 760                 765             


Lys Pro Ala Lys Ser Val Trp Glu Gln Arg Thr Ser Glu Met Arg Lys 
    770                 775                 780                 


Gln Asn Leu Leu Ala Ser Arg Glu Ala Leu Tyr Asn Glu Met Asp Pro 
785                 790                 795                 800 


Asp Glu Arg Trp Lys Ala Ala Tyr Thr Arg His Leu Arg Pro Asp Met 
                805                 810                 815     


Lys Thr His Leu Asp Arg Pro Leu Val Val Asp Pro Gln Glu Asn Arg 
            820                 825                 830         


Asn Asn Asn Thr Asn Lys Ser Arg Ala Ala Glu Pro Thr Val Asp Gln 
        835                 840                 845             


Arg Leu Gly Gln Gln Arg Ala Glu Asp Phe Leu Arg Lys Gln Ala Arg 
    850                 855                 860                 


Tyr His Asp Arg Ala Arg Asp Pro Ser Gly Ser Ala Gly Leu Asp Ala 
865                 870                 875                 880 


Arg Arg Pro Trp Ala Gly Ser Gln Glu Ala Glu Leu Ser Arg Glu Gly 
                885                 890                 895     


Pro Tyr Gly Arg Glu Ser Asp His His Ala Arg Glu Gly Ser Leu Glu 
            900                 905                 910         


Gln Pro Gly Phe Trp Glu Gly Glu Ala Glu Arg Gly Lys Ala Gly Asp 
        915                 920                 925             


Pro His Arg Arg His Val His Arg Gln Gly Gly Ser Arg Glu Ser Arg 
    930                 935                 940                 


Ser Gly Ser Pro Arg Thr Gly Ala Asp Gly Glu His Arg Arg His Arg 
945                 950                 955                 960 


Ala His Arg Arg Pro Gly Glu Glu Gly Pro Glu Asp Lys Ala Glu Arg 
                965                 970                 975     


Arg Ala Arg His Arg Glu Gly Ser Arg Pro Ala Arg Gly Gly Glu Gly 
            980                 985                 990         


Glu Gly Glu Gly Pro Asp Gly Gly  Glu Arg Arg Arg Arg  His Arg His 
        995                 1000                 1005             


Gly Ala  Pro Ala Thr Tyr Glu  Gly Asp Ala Arg Arg  Glu Asp Lys 
    1010                 1015                 1020             


Glu Arg  Arg His Arg Arg Arg  Lys Glu Asn Gln Gly  Ser Gly Val 
    1025                 1030                 1035             


Pro Val  Ser Gly Pro Asn Leu  Ser Thr Thr Arg Pro  Ile Gln Gln 
    1040                 1045                 1050             


Asp Leu  Gly Arg Gln Asp Pro  Pro Leu Ala Glu Asp  Ile Asp Asn 
    1055                 1060                 1065             


Met Lys  Asn Asn Lys Leu Ala  Thr Ala Glu Ser Ala  Ala Pro His 
    1070                 1075                 1080             


Gly Ser  Leu Gly His Ala Gly  Leu Pro Gln Ser Pro  Ala Lys Met 
    1085                 1090                 1095             


Gly Asn  Ser Thr Asp Pro Gly  Pro Met Leu Ala Ile  Pro Ala Met 
    1100                 1105                 1110             


Ala Thr  Asn Pro Gln Asn Ala  Ala Ser Arg Arg Thr  Pro Asn Asn 
    1115                 1120                 1125             


Pro Gly  Asn Pro Ser Asn Pro  Gly Pro Pro Lys Thr  Pro Glu Asn 
    1130                 1135                 1140             


Ser Leu  Ile Val Thr Asn Pro  Ser Gly Thr Gln Thr  Asn Ser Ala 
    1145                 1150                 1155             


Lys Thr  Ala Arg Lys Pro Asp  His Thr Thr Val Asp  Ile Pro Pro 
    1160                 1165                 1170             


Ala Cys  Pro Pro Pro Leu Asn  His Thr Val Val Gln  Val Asn Lys 
    1175                 1180                 1185             


Asn Ala  Asn Pro Asp Pro Leu  Pro Lys Lys Glu Glu  Glu Lys Lys 
    1190                 1195                 1200             


Glu Glu  Glu Glu Asp Asp Arg  Gly Glu Asp Gly Pro  Lys Pro Met 
    1205                 1210                 1215             


Pro Pro  Tyr Ser Ser Met Phe  Ile Leu Ser Thr Thr  Asn Pro Leu 
    1220                 1225                 1230             


Arg Arg  Leu Cys His Tyr Ile  Leu Asn Leu Arg Tyr  Phe Glu Met 
    1235                 1240                 1245             


Cys Ile  Leu Met Val Ile Ala  Met Ser Ser Ile Ala  Leu Ala Ala 
    1250                 1255                 1260             


Glu Asp  Pro Val Gln Pro Asn  Ala Pro Arg Asn Asn  Val Leu Arg 
    1265                 1270                 1275             


Tyr Phe  Asp Tyr Val Phe Thr  Gly Val Phe Thr Phe  Glu Met Val 
    1280                 1285                 1290             


Ile Lys  Met Ile Asp Leu Gly  Leu Val Leu His Gln  Gly Ala Tyr 
    1295                 1300                 1305             


Phe Arg  Asp Leu Trp Asn Ile  Leu Asp Phe Ile Val  Val Ser Gly 
    1310                 1315                 1320             


Ala Leu  Val Ala Phe Ala Phe  Thr Gly Asn Ser Lys  Gly Lys Asp 
    1325                 1330                 1335             


Ile Asn  Thr Ile Lys Ser Leu  Arg Val Leu Arg Val  Leu Arg Pro 
    1340                 1345                 1350             


Leu Lys  Thr Ile Lys Arg Leu  Pro Lys Leu Lys Ala  Val Phe Asp 
    1355                 1360                 1365             


Cys Val  Val Asn Ser Leu Lys  Asn Val Phe Asn Ile  Leu Ile Val 
    1370                 1375                 1380             


Tyr Met  Leu Phe Met Phe Ile  Phe Ala Val Val Ala  Val Gln Leu 
    1385                 1390                 1395             


Phe Lys  Gly Lys Phe Phe His  Cys Thr Asp Glu Ser  Lys Glu Phe 
    1400                 1405                 1410             


Glu Lys  Asp Cys Arg Gly Lys  Tyr Leu Leu Tyr Glu  Lys Asn Glu 
    1415                 1420                 1425             


Val Lys  Ala Arg Asp Arg Glu  Trp Lys Lys Tyr Glu  Phe His Tyr 
    1430                 1435                 1440             


Asp Asn  Val Leu Trp Ala Leu  Leu Thr Leu Phe Thr  Val Ser Thr 
    1445                 1450                 1455             


Gly Glu  Gly Trp Pro Gln Val  Leu Lys His Ser Val  Asp Ala Thr 
    1460                 1465                 1470             


Phe Glu  Asn Gln Gly Pro Ser  Pro Gly Tyr Arg Met  Glu Met Ser 
    1475                 1480                 1485             


Ile Phe  Tyr Val Val Tyr Phe  Val Val Phe Pro Phe  Phe Phe Val 
    1490                 1495                 1500             


Asn Ile  Phe Val Ala Leu Ile  Ile Ile Thr Phe Gln  Glu Gln Gly 
    1505                 1510                 1515             


Asp Lys  Met Met Glu Glu Tyr  Ser Leu Glu Lys Asn  Glu Arg Ala 
    1520                 1525                 1530             


Cys Ile  Asp Phe Ala Ile Ser  Ala Lys Pro Leu Thr  Arg His Met 
    1535                 1540                 1545             


Pro Gln  Asn Lys Gln Ser Phe  Gln Tyr Arg Met Trp  Gln Phe Val 
    1550                 1555                 1560             


Val Ser  Pro Pro Phe Glu Tyr  Thr Ile Met Ala Met  Ile Ala Leu 
    1565                 1570                 1575             


Asn Thr  Ile Val Leu Met Met  Lys Phe Tyr Gly Ala  Ser Val Ala 
    1580                 1585                 1590             


Tyr Glu  Asn Ala Leu Arg Val  Phe Asn Ile Val Phe  Thr Ser Leu 
    1595                 1600                 1605             


Phe Ser  Leu Glu Cys Val Leu  Lys Val Met Ala Phe  Gly Ile Leu 
    1610                 1615                 1620             


Asn Tyr  Phe Arg Asp Ala Trp  Asn Ile Phe Asp Phe  Val Thr Val 
    1625                 1630                 1635             


Leu Gly  Ser Ile Thr Asp Ile  Leu Val Thr Glu Phe  Gly Asn Asn 
    1640                 1645                 1650             


Phe Ile  Asn Leu Ser Phe Leu  Arg Leu Phe Arg Ala  Ala Arg Leu 
    1655                 1660                 1665             


Ile Lys  Leu Leu Arg Gln Gly  Tyr Thr Ile Arg Ile  Leu Leu Trp 
    1670                 1675                 1680             


Thr Phe  Val Gln Ser Phe Lys  Ala Leu Pro Tyr Val  Cys Leu Leu 
    1685                 1690                 1695             


Ile Ala  Met Leu Phe Phe Ile  Tyr Ala Ile Ile Gly  Met Gln Val 
    1700                 1705                 1710             


Phe Gly  Asn Ile Gly Ile Asp  Val Glu Asp Glu Asp  Ser Asp Glu 
    1715                 1720                 1725             


Asp Glu  Phe Gln Ile Thr Glu  His Asn Asn Phe Arg  Thr Phe Phe 
    1730                 1735                 1740             


Gln Ala  Leu Met Leu Leu Phe  Arg Ser Ala Thr Gly  Glu Ala Trp 
    1745                 1750                 1755             


His Asn  Ile Met Leu Ser Cys  Leu Ser Gly Lys Pro  Cys Asp Lys 
    1760                 1765                 1770             


Asn Ser  Gly Ile Leu Thr Arg  Glu Cys Gly Asn Glu  Phe Ala Tyr 
    1775                 1780                 1785             


Phe Tyr  Phe Val Ser Phe Ile  Phe Leu Cys Ser Phe  Leu Met Leu 
    1790                 1795                 1800             


Asn Leu  Phe Val Ala Val Ile  Met Asp Asn Phe Glu  Tyr Leu Thr 
    1805                 1810                 1815             


Arg Asp  Ser Ser Ile Leu Gly  Pro His His Leu Asp  Glu Tyr Val 
    1820                 1825                 1830             


Arg Val  Trp Ala Glu Tyr Asp  Pro Ala Ala Cys Gly  Arg Ile His 
    1835                 1840                 1845             


Tyr Lys  Asp Met Tyr Ser Leu  Leu Arg Val Ile Ser  Pro Pro Leu 
    1850                 1855                 1860             


Gly Leu  Gly Lys Lys Cys Pro  His Arg Val Ala Cys  Lys Arg Leu 
    1865                 1870                 1875             


Leu Arg  Met Asp Leu Pro Val  Ala Asp Asp Asn Thr  Val His Phe 
    1880                 1885                 1890             


Asn Ser  Thr Leu Met Ala Leu  Ile Arg Thr Ala Leu  Asp Ile Lys 
    1895                 1900                 1905             


Ile Ala  Lys Gly Gly Ala Asp  Lys Gln Gln Met Asp  Ala Glu Leu 
    1910                 1915                 1920             


Arg Lys  Glu Met Met Ala Ile  Trp Pro Asn Leu Ser  Gln Lys Thr 
    1925                 1930                 1935             


Leu Asp  Leu Leu Val Thr Pro  His Lys Ser Thr Asp  Leu Thr Val 
    1940                 1945                 1950             


Gly Lys  Ile Tyr Ala Ala Met  Met Ile Met Glu Tyr  Tyr Arg Gln 
    1955                 1960                 1965             


Ser Lys  Ala Lys Lys Leu Gln  Ala Met Arg Glu Glu  Gln Asp Arg 
    1970                 1975                 1980             


Thr Pro  Leu Met Phe Gln Arg  Met Glu Pro Pro Ser  Pro Thr Gln 
    1985                 1990                 1995             


Glu Gly  Gly Pro Gly Gln Asn  Ala Leu Pro Ser Thr  Gln Leu Asp 
    2000                 2005                 2010             


Pro Gly  Gly Ala Leu Met Ala  His Glu Ser Gly Leu  Lys Glu Ser 
    2015                 2020                 2025             


Pro Ser  Trp Val Thr Gln Arg  Ala Gln Glu Met Phe  Gln Lys Thr 
    2030                 2035                 2040             


Gly Thr  Trp Ser Pro Glu Gln  Gly Pro Pro Thr Asp  Met Pro Asn 
    2045                 2050                 2055             


Ser Gln  Pro Asn Ser Gln Ser  Val Glu Met Arg Glu  Met Gly Arg 
    2060                 2065                 2070             


Asp Gly  Tyr Ser Asp Ser Glu  His Tyr Leu Pro Met  Glu Gly Gln 
    2075                 2080                 2085             


Gly Arg  Ala Ala Ser Met Pro  Arg Leu Pro Ala Glu  Asn Gln Arg 
    2090                 2095                 2100             


Arg Arg  Gly Arg Pro Arg Gly  Asn Asn Leu Ser Thr  Ile Ser Asp 
    2105                 2110                 2115             


Thr Ser  Pro Met Lys Arg Ser  Ala Ser Val Leu Gly  Pro Lys Ala 
    2120                 2125                 2130             


Arg Arg  Leu Asp Asp Tyr Ser  Leu Glu Arg Val Pro  Pro Glu Glu 
    2135                 2140                 2145             


Asn Gln  Arg His His Gln Arg  Arg Arg Asp Arg Ser  His Arg Ala 
    2150                 2155                 2160             


Ser Glu  Arg Ser Leu Gly Arg  Tyr Thr Asp Val Asp  Thr Gly Leu 
    2165                 2170                 2175             


Gly Thr  Asp Leu Ser Met Thr  Thr Gln Ser Gly Asp  Leu Pro Ser 
    2180                 2185                 2190             


Lys Glu  Arg Asp Gln Glu Arg  Gly Arg Pro Lys Asp  Arg Lys His 
    2195                 2200                 2205             


Arg Gln  His His His His His  His His His His His  Pro Pro Pro 
    2210                 2215                 2220             


Pro Asp  Lys Asp Arg Tyr Ala  Gln Glu Arg Pro Asp  His Gly Arg 
    2225                 2230                 2235             


Ala Arg  Ala Arg Asp Gln Arg  Trp Ser Arg Ser Pro  Ser Glu Gly 
    2240                 2245                 2250             


Arg Glu  His Met Ala His Arg  Gln 
    2255                 2260     


<210>  1314
<211>  2506
<212>  PRT
<213>  Homo sapiens

<400>  1314

Met Ala Arg Phe Gly Asp Glu Met Pro Ala Arg Tyr Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Ala Ala Ala Gly Val Val Val Gly Ser Gly Gly Gly Arg Gly 
            20                  25                  30          


Ala Gly Gly Ser Arg Gln Gly Gly Gln Pro Gly Ala Gln Arg Met Tyr 
        35                  40                  45              


Lys Gln Ser Met Ala Gln Arg Ala Arg Thr Met Ala Leu Tyr Asn Pro 
    50                  55                  60                  


Ile Pro Val Arg Gln Asn Cys Leu Thr Val Asn Arg Ser Leu Phe Leu 
65                  70                  75                  80  


Phe Ser Glu Asp Asn Val Val Arg Lys Tyr Ala Lys Lys Ile Thr Glu 
                85                  90                  95      


Trp Pro Pro Phe Glu Tyr Met Ile Leu Ala Thr Ile Ile Ala Asn Cys 
            100                 105                 110         


Ile Val Leu Ala Leu Glu Gln His Leu Pro Asp Asp Asp Lys Thr Pro 
        115                 120                 125             


Met Ser Glu Arg Leu Asp Asp Thr Glu Pro Tyr Phe Ile Gly Ile Phe 
    130                 135                 140                 


Cys Phe Glu Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Ala Phe His 
145                 150                 155                 160 


Lys Gly Ser Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val Val 
                165                 170                 175     


Val Leu Thr Gly Ile Leu Ala Thr Val Gly Thr Glu Phe Asp Leu Arg 
            180                 185                 190         


Thr Leu Arg Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly 
        195                 200                 205             


Ile Pro Ser Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met Ile 
    210                 215                 220                 


Pro Leu Leu Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Ile Phe 
225                 230                 235                 240 


Ala Ile Ile Gly Leu Glu Phe Tyr Met Gly Lys Phe His Thr Thr Cys 
                245                 250                 255     


Phe Glu Glu Gly Thr Asp Asp Ile Gln Gly Glu Ser Pro Ala Pro Cys 
            260                 265                 270         


Gly Thr Glu Glu Pro Ala Arg Thr Cys Pro Asn Gly Thr Lys Cys Gln 
        275                 280                 285             


Pro Tyr Trp Glu Gly Pro Asn Asn Gly Ile Thr Gln Phe Asp Asn Ile 
    290                 295                 300                 


Leu Phe Ala Val Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp 
305                 310                 315                 320 


Thr Asp Leu Leu Tyr Asn Ser Asn Asp Ala Ser Gly Asn Thr Trp Asn 
                325                 330                 335     


Trp Leu Tyr Phe Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met Leu 
            340                 345                 350         


Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg Glu 
        355                 360                 365             


Arg Val Glu Asn Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln Gln 
    370                 375                 380                 


Ile Glu Arg Glu Leu Asn Gly Tyr Met Glu Trp Ile Ser Lys Ala Glu 
385                 390                 395                 400 


Glu Val Ile Leu Ala Glu Asp Glu Thr Asp Gly Glu Gln Arg His Pro 
                405                 410                 415     


Phe Asp Ala Leu Arg Arg Thr Thr Ile Lys Lys Ser Lys Thr Asp Leu 
            420                 425                 430         


Leu Asn Pro Glu Glu Ala Glu Asp Gln Leu Ala Asp Ile Ala Ser Val 
        435                 440                 445             


Gly Ser Pro Phe Ala Arg Ala Ser Ile Lys Ser Ala Lys Leu Glu Asn 
    450                 455                 460                 


Ser Thr Phe Phe His Lys Lys Glu Arg Arg Met Arg Phe Tyr Ile Arg 
465                 470                 475                 480 


Arg Met Val Lys Thr Gln Ala Phe Tyr Trp Thr Val Leu Ser Leu Val 
                485                 490                 495     


Ala Leu Asn Thr Leu Cys Val Ala Ile Val His Tyr Asn Gln Pro Glu 
            500                 505                 510         


Trp Leu Ser Asp Phe Leu Tyr Tyr Ala Glu Phe Ile Phe Leu Gly Leu 
        515                 520                 525             


Phe Met Ser Glu Met Phe Ile Lys Met Tyr Gly Leu Gly Thr Arg Pro 
    530                 535                 540                 


Tyr Phe His Ser Ser Phe Asn Cys Phe Asp Cys Gly Val Ile Ile Gly 
545                 550                 555                 560 


Ser Ile Phe Glu Val Ile Trp Ala Val Ile Lys Pro Gly Thr Ser Phe 
                565                 570                 575     


Gly Ile Ser Val Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys Val 
            580                 585                 590         


Thr Lys Tyr Trp Ala Ser Leu Arg Asn Leu Val Val Ser Leu Leu Asn 
        595                 600                 605             


Ser Met Lys Ser Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu Phe Ile 
    610                 615                 620                 


Val Val Phe Ala Leu Leu Gly Met Gln Leu Phe Gly Gly Gln Phe Asn 
625                 630                 635                 640 


Phe Asp Glu Gly Thr Pro Pro Thr Asn Phe Asp Thr Phe Pro Ala Ala 
                645                 650                 655     


Ile Met Thr Val Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Glu Val 
            660                 665                 670         


Met Tyr Asp Gly Ile Lys Ser Gln Gly Gly Val Gln Gly Gly Met Val 
        675                 680                 685             


Phe Ser Ile Tyr Phe Ile Val Leu Thr Leu Phe Gly Asn Tyr Thr Leu 
    690                 695                 700                 


Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asn Ala Gln 
705                 710                 715                 720 


Glu Leu Thr Lys Asp Glu Gln Glu Glu Glu Glu Ala Ala Asn Gln Lys 
                725                 730                 735     


Leu Ala Leu Gln Lys Ala Lys Glu Val Ala Glu Val Ser Pro Leu Ser 
            740                 745                 750         


Ala Ala Asn Met Ser Ile Ala Val Lys Glu Gln Gln Lys Asn Gln Lys 
        755                 760                 765             


Pro Ala Lys Ser Val Trp Glu Gln Arg Thr Ser Glu Met Arg Lys Gln 
    770                 775                 780                 


Asn Leu Leu Ala Ser Arg Glu Ala Leu Tyr Asn Glu Met Asp Pro Asp 
785                 790                 795                 800 


Glu Arg Trp Lys Ala Ala Tyr Thr Arg His Leu Arg Pro Asp Met Lys 
                805                 810                 815     


Thr His Leu Asp Arg Pro Leu Val Val Asp Pro Gln Glu Asn Arg Asn 
            820                 825                 830         


Asn Asn Thr Asn Lys Ser Arg Ala Ala Glu Pro Thr Val Asp Gln Arg 
        835                 840                 845             


Leu Gly Gln Gln Arg Ala Glu Asp Phe Leu Arg Lys Gln Ala Arg Tyr 
    850                 855                 860                 


His Asp Arg Ala Arg Asp Pro Ser Gly Ser Ala Gly Leu Asp Ala Arg 
865                 870                 875                 880 


Arg Pro Trp Ala Gly Ser Gln Glu Ala Glu Leu Ser Arg Glu Gly Pro 
                885                 890                 895     


Tyr Gly Arg Glu Ser Asp His His Ala Arg Glu Gly Ser Leu Glu Gln 
            900                 905                 910         


Pro Gly Phe Trp Glu Gly Glu Ala Glu Arg Gly Lys Ala Gly Asp Pro 
        915                 920                 925             


His Arg Arg His Val His Arg Gln Gly Gly Ser Arg Glu Ser Arg Ser 
    930                 935                 940                 


Gly Ser Pro Arg Thr Gly Ala Asp Gly Glu His Arg Arg His Arg Ala 
945                 950                 955                 960 


His Arg Arg Pro Gly Glu Glu Gly Pro Glu Asp Lys Ala Glu Arg Arg 
                965                 970                 975     


Ala Arg His Arg Glu Gly Ser Arg Pro Ala Arg Gly Gly Glu Gly Glu 
            980                 985                 990         


Gly Glu Gly Pro Asp Gly Gly Glu  Arg Arg Arg Arg His  Arg His Gly 
        995                 1000                 1005             


Ala Pro  Ala Thr Tyr Glu Gly  Asp Ala Arg Arg Glu  Asp Lys Glu 
    1010                 1015                 1020             


Arg Arg  His Arg Arg Arg Lys  Glu Asn Gln Gly Ser  Gly Val Pro 
    1025                 1030                 1035             


Val Ser  Gly Pro Asn Leu Ser  Thr Thr Arg Pro Ile  Gln Gln Asp 
    1040                 1045                 1050             


Leu Gly  Arg Gln Asp Pro Pro  Leu Ala Glu Asp Ile  Asp Asn Met 
    1055                 1060                 1065             


Lys Asn  Asn Lys Leu Ala Thr  Ala Glu Ser Ala Ala  Pro His Gly 
    1070                 1075                 1080             


Ser Leu  Gly His Ala Gly Leu  Pro Gln Ser Pro Ala  Lys Met Gly 
    1085                 1090                 1095             


Asn Ser  Thr Asp Pro Gly Pro  Met Leu Ala Ile Pro  Ala Met Ala 
    1100                 1105                 1110             


Thr Asn  Pro Gln Asn Ala Ala  Ser Arg Arg Thr Pro  Asn Asn Pro 
    1115                 1120                 1125             


Gly Asn  Pro Ser Asn Pro Gly  Pro Pro Lys Thr Pro  Glu Asn Ser 
    1130                 1135                 1140             


Leu Ile  Val Thr Asn Pro Ser  Gly Thr Gln Thr Asn  Ser Ala Lys 
    1145                 1150                 1155             


Thr Ala  Arg Lys Pro Asp His  Thr Thr Val Asp Ile  Pro Pro Ala 
    1160                 1165                 1170             


Cys Pro  Pro Pro Leu Asn His  Thr Val Val Gln Val  Asn Lys Asn 
    1175                 1180                 1185             


Ala Asn  Pro Asp Pro Leu Pro  Lys Lys Glu Glu Glu  Lys Lys Glu 
    1190                 1195                 1200             


Glu Glu  Glu Asp Asp Arg Gly  Glu Asp Gly Pro Lys  Pro Met Pro 
    1205                 1210                 1215             


Pro Tyr  Ser Ser Met Phe Ile  Leu Ser Thr Thr Asn  Pro Leu Arg 
    1220                 1225                 1230             


Arg Leu  Cys His Tyr Ile Leu  Asn Leu Arg Tyr Phe  Glu Met Cys 
    1235                 1240                 1245             


Ile Leu  Met Val Ile Ala Met  Ser Ser Ile Ala Leu  Ala Ala Glu 
    1250                 1255                 1260             


Asp Pro  Val Gln Pro Asn Ala  Pro Arg Asn Asn Val  Leu Arg Tyr 
    1265                 1270                 1275             


Phe Asp  Tyr Val Phe Thr Gly  Val Phe Thr Phe Glu  Met Val Ile 
    1280                 1285                 1290             


Lys Met  Ile Asp Leu Gly Leu  Val Leu His Gln Gly  Ala Tyr Phe 
    1295                 1300                 1305             


Arg Asp  Leu Trp Asn Ile Leu  Asp Phe Ile Val Val  Ser Gly Ala 
    1310                 1315                 1320             


Leu Val  Ala Phe Ala Phe Thr  Gly Asn Ser Lys Gly  Lys Asp Ile 
    1325                 1330                 1335             


Asn Thr  Ile Lys Ser Leu Arg  Val Leu Arg Val Leu  Arg Pro Leu 
    1340                 1345                 1350             


Lys Thr  Ile Lys Arg Leu Pro  Lys Leu Lys Ala Val  Phe Asp Cys 
    1355                 1360                 1365             


Val Val  Asn Ser Leu Lys Asn  Val Phe Asn Ile Leu  Ile Val Tyr 
    1370                 1375                 1380             


Met Leu  Phe Met Phe Ile Phe  Ala Val Val Ala Val  Gln Leu Phe 
    1385                 1390                 1395             


Lys Gly  Lys Phe Phe His Cys  Thr Asp Glu Ser Lys  Glu Phe Glu 
    1400                 1405                 1410             


Lys Asp  Cys Arg Gly Lys Tyr  Leu Leu Tyr Glu Lys  Asn Glu Val 
    1415                 1420                 1425             


Lys Ala  Arg Asp Arg Glu Trp  Lys Lys Tyr Glu Phe  His Tyr Asp 
    1430                 1435                 1440             


Asn Val  Leu Trp Ala Leu Leu  Thr Leu Phe Thr Val  Ser Thr Gly 
    1445                 1450                 1455             


Glu Gly  Trp Pro Gln Val Leu  Lys His Ser Val Asp  Ala Thr Phe 
    1460                 1465                 1470             


Glu Asn  Gln Gly Pro Ser Pro  Gly Tyr Arg Met Glu  Met Ser Ile 
    1475                 1480                 1485             


Phe Tyr  Val Val Tyr Phe Val  Val Phe Pro Phe Phe  Phe Val Asn 
    1490                 1495                 1500             


Ile Phe  Val Ala Leu Ile Ile  Ile Thr Phe Gln Glu  Gln Gly Asp 
    1505                 1510                 1515             


Lys Met  Met Glu Glu Tyr Ser  Leu Glu Lys Asn Glu  Arg Ala Cys 
    1520                 1525                 1530             


Ile Asp  Phe Ala Ile Ser Ala  Lys Pro Leu Thr Arg  His Met Pro 
    1535                 1540                 1545             


Gln Asn  Lys Gln Ser Phe Gln  Tyr Arg Met Trp Gln  Phe Val Val 
    1550                 1555                 1560             


Ser Pro  Pro Phe Glu Tyr Thr  Ile Met Ala Met Ile  Ala Leu Asn 
    1565                 1570                 1575             


Thr Ile  Val Leu Met Met Lys  Phe Tyr Gly Ala Ser  Val Ala Tyr 
    1580                 1585                 1590             


Glu Asn  Ala Leu Arg Val Phe  Asn Ile Val Phe Thr  Ser Leu Phe 
    1595                 1600                 1605             


Ser Leu  Glu Cys Val Leu Lys  Val Met Ala Phe Gly  Ile Leu Asn 
    1610                 1615                 1620             


Tyr Phe  Arg Asp Ala Trp Asn  Ile Phe Asp Phe Val  Thr Val Leu 
    1625                 1630                 1635             


Gly Ser  Ile Thr Asp Ile Leu  Val Thr Glu Phe Gly  Asn Asn Phe 
    1640                 1645                 1650             


Ile Asn  Leu Ser Phe Leu Arg  Leu Phe Arg Ala Ala  Arg Leu Ile 
    1655                 1660                 1665             


Lys Leu  Leu Arg Gln Gly Tyr  Thr Ile Arg Ile Leu  Leu Trp Thr 
    1670                 1675                 1680             


Phe Val  Gln Ser Phe Lys Ala  Leu Pro Tyr Val Cys  Leu Leu Ile 
    1685                 1690                 1695             


Ala Met  Leu Phe Phe Ile Tyr  Ala Ile Ile Gly Met  Gln Val Phe 
    1700                 1705                 1710             


Gly Asn  Ile Gly Ile Asp Val  Glu Asp Glu Asp Ser  Asp Glu Asp 
    1715                 1720                 1725             


Glu Phe  Gln Ile Thr Glu His  Asn Asn Phe Arg Thr  Phe Phe Gln 
    1730                 1735                 1740             


Ala Leu  Met Leu Leu Phe Arg  Ser Ala Thr Gly Glu  Ala Trp His 
    1745                 1750                 1755             


Asn Ile  Met Leu Ser Cys Leu  Ser Gly Lys Pro Cys  Asp Lys Asn 
    1760                 1765                 1770             


Ser Gly  Ile Leu Thr Arg Glu  Cys Gly Asn Glu Phe  Ala Tyr Phe 
    1775                 1780                 1785             


Tyr Phe  Val Ser Phe Ile Phe  Leu Cys Ser Phe Leu  Met Leu Asn 
    1790                 1795                 1800             


Leu Phe  Val Ala Val Ile Met  Asp Asn Phe Glu Tyr  Leu Thr Arg 
    1805                 1810                 1815             


Asp Ser  Ser Ile Leu Gly Pro  His His Leu Asp Glu  Tyr Val Arg 
    1820                 1825                 1830             


Val Trp  Ala Glu Tyr Asp Pro  Ala Ala Trp Gly Arg  Met Pro Tyr 
    1835                 1840                 1845             


Leu Asp  Met Tyr Gln Met Leu  Arg His Met Ser Pro  Pro Leu Gly 
    1850                 1855                 1860             


Leu Gly  Lys Lys Cys Pro Ala  Arg Val Ala Tyr Lys  Arg Leu Leu 
    1865                 1870                 1875             


Arg Met  Asp Leu Pro Val Ala  Asp Asp Asn Thr Val  His Phe Asn 
    1880                 1885                 1890             


Ser Thr  Leu Met Ala Leu Ile  Arg Thr Ala Leu Asp  Ile Lys Ile 
    1895                 1900                 1905             


Ala Lys  Gly Gly Ala Asp Lys  Gln Gln Met Asp Ala  Glu Leu Arg 
    1910                 1915                 1920             


Lys Glu  Met Met Ala Ile Trp  Pro Asn Leu Ser Gln  Lys Thr Leu 
    1925                 1930                 1935             


Asp Leu  Leu Val Thr Pro His  Lys Ser Thr Asp Leu  Thr Val Gly 
    1940                 1945                 1950             


Lys Ile  Tyr Ala Ala Met Met  Ile Met Glu Tyr Tyr  Arg Gln Ser 
    1955                 1960                 1965             


Lys Ala  Lys Lys Leu Gln Ala  Met Arg Glu Glu Gln  Asp Arg Thr 
    1970                 1975                 1980             


Pro Leu  Met Phe Gln Arg Met  Glu Pro Pro Ser Pro  Thr Gln Glu 
    1985                 1990                 1995             


Gly Gly  Pro Gly Gln Asn Ala  Leu Pro Ser Thr Gln  Leu Asp Pro 
    2000                 2005                 2010             


Gly Gly  Ala Leu Met Ala His  Glu Ser Gly Leu Lys  Glu Ser Pro 
    2015                 2020                 2025             


Ser Trp  Val Thr Gln Arg Ala  Gln Glu Met Phe Gln  Lys Thr Gly 
    2030                 2035                 2040             


Thr Trp  Ser Pro Glu Gln Gly  Pro Pro Thr Asp Met  Pro Asn Ser 
    2045                 2050                 2055             


Gln Pro  Asn Ser Gln Ser Val  Glu Met Arg Glu Met  Gly Arg Asp 
    2060                 2065                 2070             


Gly Tyr  Ser Asp Ser Glu His  Tyr Leu Pro Met Glu  Gly Gln Gly 
    2075                 2080                 2085             


Arg Ala  Ala Ser Met Pro Arg  Leu Pro Ala Glu Asn  Gln Arg Arg 
    2090                 2095                 2100             


Arg Gly  Arg Pro Arg Gly Asn  Asn Leu Ser Thr Ile  Ser Asp Thr 
    2105                 2110                 2115             


Ser Pro  Met Lys Arg Ser Ala  Ser Val Leu Gly Pro  Lys Ala Arg 
    2120                 2125                 2130             


Arg Leu  Asp Asp Tyr Ser Leu  Glu Arg Val Pro Pro  Glu Glu Asn 
    2135                 2140                 2145             


Gln Arg  His His Gln Arg Arg  Arg Asp Arg Ser His  Arg Ala Ser 
    2150                 2155                 2160             


Glu Arg  Ser Leu Gly Arg Tyr  Thr Asp Val Asp Thr  Gly Leu Gly 
    2165                 2170                 2175             


Thr Asp  Leu Ser Met Thr Thr  Gln Ser Gly Asp Leu  Pro Ser Lys 
    2180                 2185                 2190             


Glu Arg  Asp Gln Glu Arg Gly  Arg Pro Lys Asp Arg  Lys His Arg 
    2195                 2200                 2205             


Gln His  His His His His His  His His His His Pro  Pro Pro Pro 
    2210                 2215                 2220             


Asp Lys  Asp Arg Tyr Ala Gln  Glu Arg Pro Asp His  Gly Arg Ala 
    2225                 2230                 2235             


Arg Ala  Arg Asp Gln Arg Trp  Ser Arg Ser Pro Ser  Glu Gly Arg 
    2240                 2245                 2250             


Glu His  Met Ala His Arg Gln  Gly Ser Ser Ser Val  Ser Gly Ser 
    2255                 2260                 2265             


Pro Ala  Pro Ser Thr Ser Gly  Thr Ser Thr Pro Arg  Arg Gly Arg 
    2270                 2275                 2280             


Arg Gln  Leu Pro Gln Thr Pro  Ser Thr Pro Arg Pro  His Val Ser 
    2285                 2290                 2295             


Tyr Ser  Pro Val Ile Arg Lys  Ala Gly Gly Ser Gly  Pro Pro Gln 
    2300                 2305                 2310             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Ala Val Ala 
    2315                 2320                 2325             


Arg Pro  Gly Arg Ala Ala Thr  Ser Gly Pro Arg Arg  Tyr Pro Gly 
    2330                 2335                 2340             


Pro Thr  Ala Glu Pro Leu Ala  Gly Asp Arg Pro Pro  Thr Gly Gly 
    2345                 2350                 2355             


His Ser  Ser Gly Arg Ser Pro  Arg Met Glu Arg Arg  Val Pro Gly 
    2360                 2365                 2370             


Pro Ala  Arg Ser Glu Ser Pro  Arg Ala Cys Arg His  Gly Gly Ala 
    2375                 2380                 2385             


Arg Trp  Pro Ala Ser Gly Pro  His Val Ser Glu Gly  Pro Pro Gly 
    2390                 2395                 2400             


Pro Arg  His His Gly Tyr Tyr  Arg Gly Ser Asp Tyr  Asp Glu Ala 
    2405                 2410                 2415             


Asp Gly  Pro Gly Ser Gly Gly  Gly Glu Glu Ala Met  Ala Gly Ala 
    2420                 2425                 2430             


Tyr Asp  Ala Pro Pro Pro Val  Arg His Ala Ser Ser  Gly Ala Thr 
    2435                 2440                 2445             


Gly Arg  Ser Pro Arg Thr Pro  Arg Ala Ser Gly Pro  Ala Cys Ala 
    2450                 2455                 2460             


Ser Pro  Ser Arg His Gly Arg  Arg Leu Pro Asn Gly  Tyr Tyr Pro 
    2465                 2470                 2475             


Ala His  Gly Leu Ala Arg Pro  Arg Gly Pro Gly Ser  Arg Lys Gly 
    2480                 2485                 2490             


Leu His  Glu Pro Tyr Ser Glu  Ser Asp Asp Asp Trp  Cys 
    2495                 2500                 2505     


<210>  1315
<211>  810
<212>  PRT
<213>  Homo sapiens

<400>  1315

Met Ile Pro Val Thr Glu Leu Arg Tyr Phe Ala Asp Thr Gln Pro Ala 
1               5                   10                  15      


Tyr Arg Ile Leu Lys Pro Trp Trp Asp Val Phe Thr Asp Tyr Ile Ser 
            20                  25                  30          


Ile Val Met Leu Met Ile Ala Val Phe Gly Gly Thr Leu Gln Val Thr 
        35                  40                  45              


Gln Asp Lys Met Ile Cys Leu Pro Cys Lys Trp Val Thr Lys Asp Ser 
    50                  55                  60                  


Cys Asn Asp Ser Phe Arg Gly Trp Ala Ala Pro Gly Pro Glu Pro Thr 
65                  70                  75                  80  


Tyr Pro Asn Ser Thr Ile Leu Pro Thr Pro Asp Thr Gly Pro Thr Gly 
                85                  90                  95      


Ile Lys Tyr Asp Leu Asp Arg His Gln Tyr Asn Tyr Val Asp Ala Val 
            100                 105                 110         


Cys Tyr Glu Asn Arg Leu His Trp Phe Ala Lys Tyr Phe Pro Tyr Leu 
        115                 120                 125             


Val Leu Leu His Thr Leu Ile Phe Leu Ala Cys Ser Asn Phe Trp Phe 
    130                 135                 140                 


Lys Phe Pro Arg Thr Ser Ser Lys Leu Glu His Phe Val Ser Ile Leu 
145                 150                 155                 160 


Leu Lys Cys Phe Asp Ser Pro Trp Thr Thr Arg Ala Leu Ser Glu Thr 
                165                 170                 175     


Val Val Glu Glu Ser Asp Pro Lys Pro Ala Phe Ser Lys Met Asn Gly 
            180                 185                 190         


Ser Met Asp Lys Lys Ser Ser Thr Val Ser Glu Asp Val Glu Ala Thr 
        195                 200                 205             


Val Pro Met Leu Gln Arg Thr Lys Ser Arg Ile Glu Gln Gly Ile Val 
    210                 215                 220                 


Asp Arg Ser Glu Thr Gly Val Leu Asp Lys Lys Glu Gly Glu Gln Ala 
225                 230                 235                 240 


Lys Ala Leu Phe Glu Lys Val Lys Lys Phe Arg Thr His Val Glu Glu 
                245                 250                 255     


Gly Asp Ile Val Tyr Arg Leu Tyr Met Arg Gln Thr Ile Ile Lys Val 
            260                 265                 270         


Ile Lys Phe Ile Leu Ile Ile Cys Tyr Thr Val Tyr Tyr Val His Asn 
        275                 280                 285             


Ile Lys Phe Asp Val Asp Cys Thr Val Asp Ile Glu Ser Leu Thr Gly 
    290                 295                 300                 


Tyr Arg Thr Tyr Arg Cys Ala His Pro Leu Ala Thr Leu Phe Lys Ile 
305                 310                 315                 320 


Leu Ala Ser Phe Tyr Ile Ser Leu Val Ile Phe Tyr Gly Leu Ile Cys 
                325                 330                 335     


Met Tyr Thr Leu Trp Trp Met Leu Arg Arg Ser Leu Lys Lys Tyr Ser 
            340                 345                 350         


Phe Glu Ser Ile Arg Glu Glu Ser Ser Tyr Ser Asp Ile Pro Asp Val 
        355                 360                 365             


Lys Asn Asp Phe Ala Phe Met Leu His Leu Ile Asp Gln Tyr Asp Pro 
    370                 375                 380                 


Leu Tyr Ser Lys Arg Phe Ala Val Phe Leu Ser Glu Val Ser Glu Asn 
385                 390                 395                 400 


Lys Leu Arg Gln Leu Asn Leu Asn Asn Glu Trp Thr Leu Asp Lys Leu 
                405                 410                 415     


Arg Gln Arg Leu Thr Lys Asn Ala Gln Asp Lys Leu Glu Leu His Leu 
            420                 425                 430         


Phe Met Leu Ser Gly Ile Pro Asp Thr Val Phe Asp Leu Val Glu Leu 
        435                 440                 445             


Glu Val Leu Lys Leu Glu Leu Ile Pro Asp Val Thr Ile Pro Pro Ser 
    450                 455                 460                 


Ile Ala Gln Leu Thr Gly Leu Lys Glu Leu Trp Leu Tyr His Thr Ala 
465                 470                 475                 480 


Ala Lys Ile Glu Ala Pro Ala Leu Ala Phe Leu Arg Glu Asn Leu Arg 
                485                 490                 495     


Ala Leu His Ile Lys Phe Thr Asp Ile Lys Glu Ile Pro Leu Trp Ile 
            500                 505                 510         


Tyr Ser Leu Lys Thr Leu Glu Glu Leu His Leu Thr Gly Asn Leu Ser 
        515                 520                 525             


Ala Glu Asn Asn Arg Tyr Ile Val Ile Asp Gly Leu Arg Glu Leu Lys 
    530                 535                 540                 


Arg Leu Lys Val Leu Arg Leu Lys Ser Asn Leu Ser Lys Leu Pro Gln 
545                 550                 555                 560 


Val Val Thr Asp Val Gly Val His Leu Gln Lys Leu Ser Ile Asn Asn 
                565                 570                 575     


Glu Gly Thr Lys Leu Ile Val Leu Asn Ser Leu Lys Lys Met Ala Asn 
            580                 585                 590         


Leu Thr Glu Leu Glu Leu Ile Arg Cys Asp Leu Glu Arg Ile Pro His 
        595                 600                 605             


Ser Ile Phe Ser Leu His Asn Leu Gln Glu Ile Asp Leu Lys Asp Asn 
    610                 615                 620                 


Asn Leu Lys Thr Ile Glu Glu Ile Ile Ser Phe Gln His Leu His Arg 
625                 630                 635                 640 


Leu Thr Cys Leu Lys Leu Trp Tyr Asn His Ile Ala Tyr Ile Pro Ile 
                645                 650                 655     


Gln Ile Gly Asn Leu Thr Asn Leu Glu Arg Leu Tyr Leu Asn Arg Asn 
            660                 665                 670         


Lys Ile Glu Lys Ile Pro Thr Gln Leu Phe Tyr Cys Arg Lys Leu Arg 
        675                 680                 685             


Tyr Leu Asp Leu Ser His Asn Asn Leu Thr Phe Leu Pro Ala Asp Ile 
    690                 695                 700                 


Gly Leu Leu Gln Asn Leu Gln Asn Leu Ala Ile Thr Ala Asn Arg Ile 
705                 710                 715                 720 


Glu Thr Leu Pro Pro Glu Leu Phe Gln Cys Arg Lys Leu Arg Ala Leu 
                725                 730                 735     


His Leu Gly Asn Asn Val Leu Gln Ser Leu Pro Ser Arg Val Gly Glu 
            740                 745                 750         


Leu Thr Asn Leu Thr Gln Ile Glu Leu Arg Gly Asn Arg Leu Glu Cys 
        755                 760                 765             


Leu Pro Val Glu Leu Gly Glu Cys Pro Leu Leu Lys Arg Ser Gly Leu 
    770                 775                 780                 


Val Val Glu Glu Asp Leu Phe Asn Thr Leu Pro Pro Glu Val Lys Glu 
785                 790                 795                 800 


Arg Leu Trp Arg Ala Asp Lys Glu Gln Ala 
                805                 810 


<210>  1316
<211>  810
<212>  PRT
<213>  Homo sapiens

<400>  1316

Met Ile Pro Val Thr Glu Leu Arg Tyr Phe Ala Asp Thr Gln Pro Ala 
1               5                   10                  15      


Tyr Arg Ile Leu Lys Pro Trp Trp Asp Val Phe Thr Asp Tyr Ile Ser 
            20                  25                  30          


Ile Val Met Leu Met Ile Ala Val Phe Gly Gly Thr Leu Gln Val Thr 
        35                  40                  45              


Gln Asp Lys Met Ile Cys Leu Pro Cys Lys Trp Val Thr Lys Asp Ser 
    50                  55                  60                  


Cys Asn Asp Ser Phe Arg Gly Trp Ala Ala Pro Gly Pro Glu Pro Thr 
65                  70                  75                  80  


Tyr Pro Asn Ser Thr Ile Leu Pro Thr Pro Asp Thr Gly Pro Thr Gly 
                85                  90                  95      


Ile Lys Tyr Asp Leu Asp Arg His Gln Tyr Asn Tyr Val Asp Ala Val 
            100                 105                 110         


Cys Tyr Glu Asn Arg Leu His Trp Phe Ala Lys Tyr Phe Pro Tyr Leu 
        115                 120                 125             


Val Leu Leu His Thr Leu Ile Phe Leu Ala Cys Ser Asn Phe Trp Phe 
    130                 135                 140                 


Lys Phe Pro Arg Thr Ser Ser Lys Leu Glu His Phe Val Ser Ile Leu 
145                 150                 155                 160 


Leu Lys Cys Phe Asp Ser Pro Trp Thr Thr Arg Ala Leu Ser Glu Thr 
                165                 170                 175     


Val Val Glu Glu Ser Asp Pro Lys Pro Ala Phe Ser Lys Met Asn Gly 
            180                 185                 190         


Ser Met Asp Lys Lys Ser Ser Thr Val Ser Glu Asp Val Glu Ala Thr 
        195                 200                 205             


Val Pro Met Leu Gln Arg Thr Lys Ser Arg Ile Glu Gln Gly Ile Val 
    210                 215                 220                 


Asp Arg Ser Glu Thr Gly Val Leu Asp Lys Lys Glu Gly Glu Gln Ala 
225                 230                 235                 240 


Lys Ala Leu Phe Glu Lys Val Lys Lys Phe Arg Thr His Val Glu Glu 
                245                 250                 255     


Gly Asp Ile Val Tyr Arg Leu Tyr Met Arg Gln Thr Ile Ile Lys Val 
            260                 265                 270         


Ile Lys Phe Ile Leu Ile Ile Cys Tyr Thr Val Tyr Tyr Val His Asn 
        275                 280                 285             


Ile Lys Phe Asp Val Asp Cys Thr Val Asp Ile Glu Ser Leu Thr Gly 
    290                 295                 300                 


Tyr Arg Thr Tyr Arg Cys Ala His Pro Leu Ala Thr Leu Phe Lys Ile 
305                 310                 315                 320 


Leu Ala Ser Phe Tyr Ile Ser Leu Val Ile Phe Tyr Gly Leu Ile Cys 
                325                 330                 335     


Met Tyr Thr Leu Trp Trp Met Leu Arg Arg Ser Leu Lys Lys Tyr Ser 
            340                 345                 350         


Phe Glu Ser Ile Arg Glu Glu Ser Ser Tyr Ser Asp Ile Pro Asp Val 
        355                 360                 365             


Lys Asn Asp Phe Ala Phe Met Leu His Leu Ile Asp Gln Tyr Asp Pro 
    370                 375                 380                 


Leu Tyr Ser Lys Arg Phe Ala Val Phe Leu Ser Glu Val Ser Glu Asn 
385                 390                 395                 400 


Lys Leu Arg Gln Leu Asn Leu Asn Asn Glu Trp Thr Leu Asp Lys Leu 
                405                 410                 415     


Arg Gln Arg Leu Thr Lys Asn Ala Gln Asp Lys Leu Glu Leu His Leu 
            420                 425                 430         


Phe Met Leu Ser Gly Ile Pro Asp Thr Val Phe Asp Leu Val Glu Leu 
        435                 440                 445             


Glu Val Leu Lys Leu Glu Leu Ile Pro Asp Val Thr Ile Pro Pro Ser 
    450                 455                 460                 


Ile Ala Gln Leu Thr Gly Leu Lys Glu Leu Trp Leu Tyr His Thr Ala 
465                 470                 475                 480 


Ala Lys Ile Glu Ala Pro Ala Leu Ala Phe Leu Arg Glu Asn Leu Arg 
                485                 490                 495     


Ala Leu His Ile Lys Phe Thr Asp Ile Lys Glu Ile Pro Leu Trp Ile 
            500                 505                 510         


Tyr Ser Leu Lys Thr Leu Glu Glu Leu His Leu Thr Gly Asn Leu Ser 
        515                 520                 525             


Ala Glu Asn Asn Arg Tyr Ile Val Ile Asp Gly Leu Arg Glu Leu Lys 
    530                 535                 540                 


Arg Leu Lys Val Leu Arg Leu Lys Ser Asn Leu Ser Lys Leu Pro Gln 
545                 550                 555                 560 


Val Val Thr Asp Val Gly Val His Leu Gln Lys Leu Ser Ile Asn Asn 
                565                 570                 575     


Glu Gly Thr Lys Leu Ile Val Leu Asn Ser Leu Lys Lys Met Ala Asn 
            580                 585                 590         


Leu Thr Glu Leu Glu Leu Ile Arg Cys Asp Leu Glu Arg Ile Pro His 
        595                 600                 605             


Ser Ile Phe Ser Leu His Asn Leu Gln Glu Ile Asp Leu Lys Asp Asn 
    610                 615                 620                 


Asn Leu Lys Thr Ile Glu Glu Ile Ile Ser Phe Gln His Leu His Arg 
625                 630                 635                 640 


Leu Thr Cys Leu Lys Leu Trp Tyr Asn His Ile Ala Tyr Ile Pro Ile 
                645                 650                 655     


Gln Ile Gly Asn Leu Thr Asn Leu Glu Arg Leu Tyr Leu Asn Arg Asn 
            660                 665                 670         


Lys Ile Glu Lys Ile Pro Thr Gln Leu Phe Tyr Cys Arg Lys Leu Arg 
        675                 680                 685             


Tyr Leu Asp Leu Ser His Asn Asn Leu Thr Phe Leu Pro Ala Asp Ile 
    690                 695                 700                 


Gly Leu Leu Gln Asn Leu Gln Asn Leu Ala Ile Thr Ala Asn Arg Ile 
705                 710                 715                 720 


Glu Thr Leu Pro Pro Glu Leu Phe Gln Cys Arg Lys Leu Arg Ala Leu 
                725                 730                 735     


His Leu Gly Asn Asn Val Leu Gln Ser Leu Pro Ser Arg Val Gly Glu 
            740                 745                 750         


Leu Thr Asn Leu Thr Gln Ile Glu Leu Arg Gly Asn Arg Leu Glu Cys 
        755                 760                 765             


Leu Pro Val Glu Leu Gly Glu Cys Pro Leu Leu Lys Arg Ser Gly Leu 
    770                 775                 780                 


Val Val Glu Glu Asp Leu Phe Asn Thr Leu Pro Pro Glu Val Lys Glu 
785                 790                 795                 800 


Arg Leu Trp Arg Ala Asp Lys Glu Gln Ala 
                805                 810 


<210>  1317
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  1317

Met Asp Ser Pro Glu Val Thr Phe Thr Leu Ala Tyr Leu Val Phe Ala 
1               5                   10                  15      


Val Cys Phe Val Phe Thr Pro Asn Glu Phe His Ala Ala Gly Leu Thr 
            20                  25                  30          


Val Gln Asn Leu Leu Ser Gly Trp Leu Gly Ser Glu Asp Ala Ala Phe 
        35                  40                  45              


Val Pro Phe His Leu Arg Arg Thr Ala Ala Thr Leu Leu Cys His Ser 
    50                  55                  60                  


Leu Leu Pro Leu Gly Tyr Tyr Val Gly Met Cys Leu Ala Ala Ser Glu 
65                  70                  75                  80  


Lys Arg Leu His Ala Leu Ser Gln Ala Pro Glu Ala Trp Arg Leu Phe 
                85                  90                  95      


Leu Leu Leu Ala Val Thr Leu Pro Ser Ile Ala Cys Ile Leu Ile Tyr 
            100                 105                 110         


Tyr Trp Ser Arg Asp Arg Trp Ala Cys His Pro Leu Ala Arg Thr Leu 
        115                 120                 125             


Ala Leu Tyr Ala Leu Pro Gln Ser Gly Trp Gln Ala Val Ala Ser Ser 
    130                 135                 140                 


Val Asn Thr Glu Phe Arg Arg Ile Asp Lys Phe Ala Thr Gly Ala Pro 
145                 150                 155                 160 


Gly Ala Arg Val Ile Val Thr Asp Thr Trp Val Met Lys Val Thr Thr 
                165                 170                 175     


Tyr Arg Val His Val Ala Gln Gln Gln Asp Val His Leu Thr Val Thr 
            180                 185                 190         


Glu Ser Arg Gln His Glu Leu Ser Pro Asp Ser Asn Leu Pro Val Gln 
        195                 200                 205             


Leu Leu Thr Ile Arg Val Ala Ser Thr Asn Pro Ala Val Gln Ala Phe 
    210                 215                 220                 


Asp Ile Trp Leu Asn Ser Thr Glu Tyr Gly Glu Leu Cys Glu Lys Leu 
225                 230                 235                 240 


Arg Ala Pro Ile Arg Arg Ala Ala His Val Val Ile His Gln Ser Leu 
                245                 250                 255     


Gly Asp Leu Phe Leu Glu Thr Phe Ala Ser Leu Val Glu Val Asn Pro 
            260                 265                 270         


Ala Tyr Ser Val Pro Ser Ser Gln Glu Leu Glu Ala Cys Ile Gly Cys 
        275                 280                 285             


Met Gln Thr Arg Ala Ser Val Lys Leu Val Lys Thr Cys Gln Glu Ala 
    290                 295                 300                 


Ala Thr Gly Glu Cys Gln Gln Cys Tyr Cys Arg Pro Met Trp Cys Leu 
305                 310                 315                 320 


Thr Cys Met Gly Lys Trp Phe Ala Ser Arg Gln Asp Pro Leu Arg Pro 
                325                 330                 335     


Asp Thr Trp Leu Ala Ser Arg Val Pro Cys Pro Thr Cys Arg Ala Arg 
            340                 345                 350         


Phe Cys Ile Leu Asp Val Cys Thr Val Arg 
        355                 360         


<210>  1318
<211>  587
<212>  PRT
<213>  Homo sapiens

<400>  1318

Met Gly Ser Glu Lys Asp Ser Glu Ser Pro Arg Ser Thr Ser Leu His 
1               5                   10                  15      


Ala Ala Ala Pro Asp Pro Lys Cys Arg Ser Gly Gly Arg Arg Arg Arg 
            20                  25                  30          


Leu Thr Leu His Ser Val Phe Ser Ala Ser Ala Arg Gly Arg Arg Ala 
        35                  40                  45              


Arg Ala Lys Pro Gln Ala Glu Pro Pro Pro Pro Ala Ala Gln Pro Pro 
    50                  55                  60                  


Pro Ala Pro Ala Pro Ala Ala Ala Gln Gly Pro Pro Pro Glu Ala Leu 
65                  70                  75                  80  


Pro Ala Glu Pro Ala Ala Glu Ala Glu Ala Glu Ala Ala Ala Ala Ala 
                85                  90                  95      


Ala Glu Pro Gly Phe Asp Asp Glu Glu Ala Ala Glu Gly Gly Gly Pro 
            100                 105                 110         


Gly Ala Glu Glu Val Glu Cys Pro Leu Cys Leu Val Arg Leu Pro Pro 
        115                 120                 125             


Glu Arg Ala Pro Arg Leu Leu Ser Cys Pro His Arg Ser Cys Arg Asp 
    130                 135                 140                 


Cys Leu Arg His Tyr Leu Arg Leu Glu Ile Ser Glu Ser Arg Val Pro 
145                 150                 155                 160 


Ile Ser Cys Pro Glu Cys Ser Glu Arg Leu Asn Pro His Asp Ile Arg 
                165                 170                 175     


Leu Leu Leu Ala Asp Pro Pro Leu Met His Lys Tyr Glu Glu Phe Met 
            180                 185                 190         


Leu Arg Arg Tyr Leu Ala Ser Asp Pro Asp Cys Arg Trp Cys Pro Ala 
        195                 200                 205             


Pro Asp Cys Gly Tyr Ala Val Ile Ala Tyr Gly Cys Ala Ser Cys Pro 
    210                 215                 220                 


Lys Leu Thr Cys Glu Arg Glu Gly Cys Gln Thr Glu Phe Cys Tyr His 
225                 230                 235                 240 


Cys Lys Gln Ile Trp His Pro Asn Gln Thr Cys Asp Met Ala Arg Gln 
                245                 250                 255     


Gln Arg Ala Gln Thr Leu Arg Val Arg Thr Lys His Thr Ser Gly Leu 
            260                 265                 270         


Ser Tyr Gly Gln Glu Ser Gly Pro Asp Asp Ile Lys Pro Cys Pro Arg 
        275                 280                 285             


Cys Ser Ala Tyr Ile Ile Lys Met Asn Asp Gly Ser Cys Asn His Met 
    290                 295                 300                 


Thr Cys Ala Val Cys Gly Cys Glu Phe Cys Trp Leu Cys Met Lys Glu 
305                 310                 315                 320 


Ile Ser Asp Leu His Tyr Leu Ser Pro Ser Gly Cys Thr Phe Trp Gly 
                325                 330                 335     


Lys Lys Pro Trp Ser Arg Lys Lys Lys Ile Leu Trp Gln Leu Gly Thr 
            340                 345                 350         


Leu Ile Gly Ala Pro Val Gly Ile Ser Leu Ile Ala Gly Ile Ala Ile 
        355                 360                 365             


Pro Ala Met Val Ile Gly Ile Pro Val Tyr Val Gly Arg Lys Ile His 
    370                 375                 380                 


Ser Arg Tyr Glu Gly Arg Lys Thr Ser Lys His Lys Arg Asn Leu Ala 
385                 390                 395                 400 


Ile Thr Gly Gly Val Thr Leu Ser Val Ile Ala Ser Pro Val Ile Ala 
                405                 410                 415     


Ala Val Ser Val Gly Ile Gly Val Pro Ile Met Leu Ala Tyr Val Tyr 
            420                 425                 430         


Gly Val Val Pro Ile Ser Leu Cys Arg Gly Gly Gly Cys Gly Val Ser 
        435                 440                 445             


Thr Ala Asn Gly Lys Gly Val Lys Ile Glu Phe Asp Glu Asp Asp Gly 
    450                 455                 460                 


Pro Ile Thr Val Ala Asp Ala Trp Arg Ala Leu Lys Asn Pro Ser Ile 
465                 470                 475                 480 


Gly Glu Ser Ser Ile Glu Gly Leu Thr Ser Val Leu Ser Thr Ser Gly 
                485                 490                 495     


Ser Pro Thr Asp Gly Leu Ser Val Met Gln Gly Pro Tyr Ser Glu Thr 
            500                 505                 510         


Ala Ser Phe Ala Ala Leu Ser Gly Gly Thr Leu Ser Gly Gly Ile Leu 
        515                 520                 525             


Ser Ser Gly Lys Gly Lys Tyr Ser Arg Leu Glu Val Gln Ala Asp Val 
    530                 535                 540                 


Gln Lys Glu Ile Phe Pro Lys Asp Thr Ala Ser Leu Gly Ala Ile Ser 
545                 550                 555                 560 


Asp Asn Ala Ser Thr Arg Ala Met Ala Gly Ser Ile Ile Ser Ser Tyr 
                565                 570                 575     


Asn Pro Gln Asp Arg Phe Ser Met Ile His Ala 
            580                 585         


<210>  1319
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  1319

Met Glu Thr Leu Ser Ser Glu Glu Ser Cys Asp Ser Phe Asp Ser Leu 
1               5                   10                  15      


Glu Ser Gly Lys Gln Gln Asp Val Arg Phe His Ser Lys Tyr Phe Thr 
            20                  25                  30          


Glu Glu Leu Arg Arg Ile Phe Ile Glu Asp Thr Asp Ser Glu Thr Glu 
        35                  40                  45              


Asp Phe Ala Gly Phe Thr Gln Ser Asp Leu Asn Gly Lys Thr Asn Pro 
    50                  55                  60                  


Glu Val Met Val Val Glu Ser Asp Leu Ser Asp Asp Gly Lys Ala Ser 
65                  70                  75                  80  


Leu Val Ser Glu Glu Glu Glu Asp Glu Glu Glu Asp Lys Ala Thr Pro 
                85                  90                  95      


Arg Arg Ser Arg Ser Arg Arg Ser Ser Ile Gly Leu Arg Val Ala Phe 
            100                 105                 110         


Gln Phe Pro Thr Lys Lys Leu Ala Asn Lys Pro Asp Lys Asn Ser Ser 
        115                 120                 125             


Ser Glu Gln Leu Phe Ser Ser Ala Arg Leu Gln Asn Glu Lys Lys Thr 
    130                 135                 140                 


Ile Leu Glu Arg Lys Lys Asp Cys Arg Gln Val Ile Gln Arg Glu Asp 
145                 150                 155                 160 


Ser Thr Ser Glu Ser Glu Asp Asp Ser Arg Asp Glu Ser Gln Glu Ser 
                165                 170                 175     


Ser Asp Ala Leu Leu Lys Arg Thr Met Asn Ile Lys Glu Asn Lys Ala 
            180                 185                 190         


Met Leu Ala Gln Leu Leu Ala Glu Leu Asn Ser Met Pro Asp Phe Phe 
        195                 200                 205             


Pro Val Arg Thr Pro Thr Ser Ala Ser Arg Lys Lys Thr Val Arg Arg 
    210                 215                 220                 


Ala Phe Ser Glu Gly Gln Ile Thr Arg Arg Met Asn Pro Thr Arg Ser 
225                 230                 235                 240 


Ala Arg Pro Pro Glu Lys Phe Ala Leu Glu Asn Phe Thr Val Ser Ala 
                245                 250                 255     


Ala Lys Phe Ala Glu Glu Phe Tyr Ser Phe Arg Arg Arg Lys Thr Ile 
            260                 265                 270         


Gly Gly Lys Cys Arg Glu Tyr Arg Arg Arg His Arg Ile Ser Ser Phe 
        275                 280                 285             


Arg Pro Val Glu Asp Ile Thr Glu Glu Asp Leu Glu Asn Val Ala Ile 
    290                 295                 300                 


Thr Val Arg Asp Lys Ile Tyr Asp Lys Val Leu Gly Asn Thr Cys His 
305                 310                 315                 320 


Gln Cys Arg Gln Lys Thr Ile Asp Thr Lys Thr Val Cys Arg Asn Gln 
                325                 330                 335     


Gly Cys Cys Gly Val Arg Gly Gln Phe Cys Gly Pro Cys Leu Arg Asn 
            340                 345                 350         


Arg Tyr Gly Glu Asp Val Arg Ser Ala Leu Leu Asp Pro Asp Trp Val 
        355                 360                 365             


Cys Pro Pro Cys Arg Gly Ile Cys Asn Cys Ser Tyr Cys Arg Lys Arg 
    370                 375                 380                 


Asp Gly Arg Cys Ala Thr Gly Ile Leu Ile His Leu Ala Lys Phe Tyr 
385                 390                 395                 400 


Gly Tyr Asp Asn Val Lys Glu Tyr Leu Glu Ser Leu Gln Lys Glu Leu 
                405                 410                 415     


Val Glu Asp Asn 
            420 


<210>  1320
<211>  408
<212>  PRT
<213>  Homo sapiens

<400>  1320

Met Glu Leu Ala Thr Arg Tyr Gln Ile Pro Lys Glu Val Ala Asp Ile 
1               5                   10                  15      


Phe Asn Ala Pro Ser Asp Asp Glu Glu Phe Val Gly Phe Arg Asp Asp 
            20                  25                  30          


Val Pro Met Glu Thr Leu Ser Ser Glu Glu Ser Cys Asp Ser Phe Asp 
        35                  40                  45              


Ser Leu Glu Ser Gly Lys Gln Val Val Glu Ser Asp Leu Ser Asp Asp 
    50                  55                  60                  


Gly Lys Ala Ser Leu Val Ser Glu Glu Glu Glu Asp Glu Glu Glu Asp 
65                  70                  75                  80  


Lys Ala Thr Pro Arg Arg Ser Arg Ser Arg Arg Ser Ser Ile Gly Leu 
                85                  90                  95      


Arg Val Ala Phe Gln Phe Pro Thr Lys Lys Leu Ala Asn Lys Pro Asp 
            100                 105                 110         


Lys Asn Ser Ser Ser Glu Gln Leu Phe Ser Ser Ala Arg Leu Gln Asn 
        115                 120                 125             


Glu Lys Lys Thr Ile Leu Glu Arg Lys Lys Asp Cys Arg Gln Val Ile 
    130                 135                 140                 


Gln Arg Glu Asp Ser Thr Ser Glu Ser Glu Asp Asp Ser Arg Asp Glu 
145                 150                 155                 160 


Ser Gln Glu Ser Ser Asp Ala Leu Leu Lys Arg Thr Met Asn Ile Lys 
                165                 170                 175     


Glu Asn Lys Ala Met Leu Ala Gln Leu Leu Ala Glu Leu Asn Ser Met 
            180                 185                 190         


Pro Asp Phe Phe Pro Val Arg Thr Pro Thr Ser Ala Ser Arg Lys Lys 
        195                 200                 205             


Thr Val Arg Arg Ala Phe Ser Glu Gly Gln Ile Thr Arg Arg Met Asn 
    210                 215                 220                 


Pro Thr Arg Ser Ala Arg Pro Pro Glu Lys Phe Ala Leu Glu Asn Phe 
225                 230                 235                 240 


Thr Val Ser Ala Ala Lys Phe Ala Glu Glu Phe Tyr Ser Phe Arg Arg 
                245                 250                 255     


Arg Lys Thr Ile Gly Gly Lys Cys Arg Glu Tyr Arg Arg Arg His Arg 
            260                 265                 270         


Ile Ser Ser Phe Arg Pro Val Glu Asp Ile Thr Glu Glu Asp Leu Glu 
        275                 280                 285             


Asn Val Ala Ile Thr Val Arg Asp Lys Ile Tyr Asp Lys Val Leu Gly 
    290                 295                 300                 


Asn Thr Cys His Gln Cys Arg Gln Lys Thr Ile Asp Thr Lys Thr Val 
305                 310                 315                 320 


Cys Arg Asn Gln Gly Cys Cys Gly Val Arg Gly Gln Phe Cys Gly Pro 
                325                 330                 335     


Cys Leu Arg Asn Arg Tyr Gly Glu Asp Val Arg Ser Ala Leu Leu Asp 
            340                 345                 350         


Pro Asp Trp Val Cys Pro Pro Cys Arg Gly Ile Cys Asn Cys Ser Tyr 
        355                 360                 365             


Cys Arg Lys Arg Asp Gly Arg Cys Ala Thr Gly Ile Leu Ile His Leu 
    370                 375                 380                 


Ala Lys Phe Tyr Gly Tyr Asp Asn Val Lys Glu Tyr Leu Glu Ser Leu 
385                 390                 395                 400 


Gln Lys Glu Leu Val Glu Asp Asn 
                405             


<210>  1321
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  1321

Met Ala Met Glu Gly Tyr Trp Arg Phe Leu Ala Leu Leu Gly Ser Ala 
1               5                   10                  15      


Leu Leu Val Gly Phe Leu Ser Val Ile Phe Ala Leu Val Trp Val Leu 
            20                  25                  30          


His Tyr Arg Glu Gly Leu Gly Trp Asp Gly Ser Ala Leu Glu Phe Asn 
        35                  40                  45              


Trp His Pro Val Leu Met Val Thr Gly Phe Val Phe Ile Gln Gly Ile 
    50                  55                  60                  


Ala Ser Phe Arg Phe Phe Ser Leu Ser Ala Ser Met Gly Ser Ala Phe 
65                  70                  75                  80  


Ser Pro Ser Ile Ser His Ala His Thr Cys Leu Phe Trp Asn Cys His 
                85                  90                  95      


Leu Trp Asn Ser Asp Cys Asn Ser Thr Tyr Gly Ile Asp Arg Glu Thr 
            100                 105                 110         


Asp Phe Phe Pro Glu Arg Ser Cys Ile Gln Tyr Ile Pro Ala Arg Arg 
        115                 120                 125             


Cys Phe Arg Lys Tyr Ala Trp Pro Ser Asp Pro Gly Val Arg Gly Pro 
    130                 135                 140                 


His Phe Leu Asp Ser His Gln Thr Ala Met Glu Thr Ser 
145                 150                 155         


<210>  1322
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  1322

Met Asp Gly Gly Gln Pro Ile Pro Ser Ser Leu Val Pro Leu Gly Asn 
1               5                   10                  15      


Glu Ser Ala Asp Ser Ser Met Ser Leu Glu Gln Lys Met Thr Phe Val 
            20                  25                  30          


Phe Val Ile Leu Leu Phe Ile Phe Leu Gly Ile Leu Ile Val Arg Cys 
        35                  40                  45              


Phe Arg Ile Leu Leu Asp Pro Tyr Arg Ser Met Pro Thr Ser Thr Trp 
    50                  55                  60                  


Ala Asp Gly Leu Glu Gly Leu Glu Lys Gly Gln Phe Asp His Ala Leu 
65                  70                  75                  80  


Ala 
    


<210>  1323
<211>  1151
<212>  PRT
<213>  Homo sapiens

<400>  1323

Met Glu Val Val Asp Glu Thr Glu Ala Leu Gln Arg Phe Phe Glu Gly 
1               5                   10                  15      


His Asp Ile Asn Gly Ala Leu Glu Pro Ser Asn Ile Asp Thr Ser Ile 
            20                  25                  30          


Leu Glu Glu Tyr Ile Ser Lys Glu Asp Ala Ser Asp Leu Cys Phe Pro 
        35                  40                  45              


Asp Ile Ser Ala Pro Ala Ser Ser Ala Ser Tyr Ser His Gly Gln Pro 
    50                  55                  60                  


Ala Met Pro Gly Ser Ser Gly Val His His Leu Ser Pro Pro Gly Gly 
65                  70                  75                  80  


Gly Pro Ser Pro Gly Arg His Gly Pro Leu Pro Pro Pro Gly Tyr Gly 
                85                  90                  95      


Thr Pro Leu Asn Cys Asn Asn Asn Asn Gly Met Gly Ala Ala Pro Lys 
            100                 105                 110         


Pro Phe Pro Gly Gly Thr Gly Pro Pro Ile Lys Ala Glu Pro Lys Ala 
        115                 120                 125             


Pro Tyr Ala Pro Gly Thr Leu Pro Asp Ser Pro Pro Asp Ser Gly Ser 
    130                 135                 140                 


Glu Ala Tyr Ser Pro Gln Gln Val Asn Glu Pro His Leu Leu Arg Thr 
145                 150                 155                 160 


Ile Thr Pro Glu Thr Leu Cys His Val Gly Val Pro Ser Arg Leu Glu 
                165                 170                 175     


His Pro Pro Pro Pro Pro Ala His Leu Pro Gly Pro Pro Pro Pro Pro 
            180                 185                 190         


Pro Pro Pro Pro His Tyr Pro Val Leu Gln Arg Asp Leu Tyr Met Lys 
        195                 200                 205             


Ala Glu Pro Pro Ile Pro His Tyr Ala Ala Met Gly Gln Gly Leu Val 
    210                 215                 220                 


Pro Thr Asp Leu His His Thr Gln Gln Ser Gln Met Leu His Gln Leu 
225                 230                 235                 240 


Leu Gln Gln His Gly Ala Glu Leu Pro Thr His Pro Ser Lys Lys Arg 
                245                 250                 255     


Lys His Ser Glu Ser Pro Pro Ser Thr Leu Asn Ala Gln Met Leu Asn 
            260                 265                 270         


Gly Met Ile Lys Gln Glu Pro Gly Thr Val Thr Ala Leu Pro Leu His 
        275                 280                 285             


Pro Thr Arg Ala Pro Ser Pro Pro Trp Pro Pro Gln Gly Pro Leu Ser 
    290                 295                 300                 


Pro Gly Pro Gly Ser Leu Pro Leu Ser Ile Ala Arg Val Gln Thr Pro 
305                 310                 315                 320 


Pro Trp His Pro Pro Gly Ala Pro Ser Pro Gly Leu Leu Gln Asp Ser 
                325                 330                 335     


Asp Ser Leu Ser Gly Ser Tyr Leu Asp Pro Asn Tyr Gln Ser Ile Lys 
            340                 345                 350         


Trp Gln Pro His Gln Gln Asn Lys Trp Ala Thr Leu Tyr Asp Ala Asn 
        355                 360                 365             


Tyr Lys Glu Leu Pro Met Leu Thr Tyr Arg Val Asp Ala Asp Lys Gly 
    370                 375                 380                 


Phe Asn Phe Ser Val Gly Asp Asp Ala Phe Val Cys Gln Lys Lys Asn 
385                 390                 395                 400 


His Phe Gln Val Thr Val Tyr Ile Gly Met Leu Gly Glu Pro Lys Tyr 
                405                 410                 415     


Val Lys Thr Pro Glu Gly Leu Lys Pro Leu Asp Cys Phe Tyr Leu Lys 
            420                 425                 430         


Leu His Gly Val Lys Leu Glu Ala Leu Asn Gln Ser Ile Asn Ile Glu 
        435                 440                 445             


Gln Ser Gln Ser Asp Arg Ser Lys Arg Pro Phe Asn Pro Val Thr Val 
    450                 455                 460                 


Asn Leu Pro Pro Glu Gln Val Thr Lys Val Thr Val Gly Arg Leu His 
465                 470                 475                 480 


Phe Ser Glu Thr Thr Ala Asn Asn Met Arg Lys Lys Gly Lys Pro Asn 
                485                 490                 495     


Pro Asp Gln Arg Tyr Phe Met Leu Val Val Ala Leu Gln Ala His Ala 
            500                 505                 510         


Gln Asn Gln Asn Tyr Thr Leu Ala Ala Gln Ile Ser Glu Arg Ile Ile 
        515                 520                 525             


Val Arg Ala Ser Asn Pro Gly Gln Phe Glu Ser Asp Ser Asp Val Leu 
    530                 535                 540                 


Trp Gln Arg Ala Gln Val Pro Asp Thr Val Phe His His Gly Arg Val 
545                 550                 555                 560 


Gly Ile Asn Thr Asp Arg Pro Asp Glu Ala Leu Val Val His Gly Asn 
                565                 570                 575     


Val Lys Val Met Gly Ser Leu Met His Pro Ser Asp Leu Arg Ala Lys 
            580                 585                 590         


Glu His Val Gln Glu Val Asp Thr Thr Glu Gln Leu Lys Arg Ile Ser 
        595                 600                 605             


Arg Met Arg Leu Val His Tyr Arg Tyr Lys Pro Glu Phe Ala Ala Ser 
    610                 615                 620                 


Ala Gly Ile Glu Ala Thr Ala Pro Glu Thr Gly Val Ile Ala Gln Glu 
625                 630                 635                 640 


Val Lys Glu Ile Leu Pro Glu Ala Val Lys Asp Thr Gly Asp Met Val 
                645                 650                 655     


Phe Ala Asn Gly Lys Thr Ile Glu Asn Phe Leu Val Val Asn Lys Glu 
            660                 665                 670         


Arg Ile Phe Met Glu Asn Val Gly Ala Val Lys Glu Leu Cys Lys Leu 
        675                 680                 685             


Thr Asp Asn Leu Glu Thr Arg Ile Asp Glu Leu Glu Arg Trp Ser His 
    690                 695                 700                 


Lys Leu Ala Lys Leu Arg Arg Leu Asp Ser Leu Lys Ser Thr Gly Ser 
705                 710                 715                 720 


Ser Gly Ala Phe Ser His Ala Gly Ser Gln Phe Ser Arg Ala Gly Ser 
                725                 730                 735     


Val Pro His Lys Lys Arg Pro Pro Lys Val Ala Ser Lys Ser Ser Ser 
            740                 745                 750         


Val Val Pro Asp Gln Ala Cys Ile Ser Gln Arg Phe Leu Gln Gly Thr 
        755                 760                 765             


Ile Ile Ala Leu Val Val Val Met Ala Phe Ser Val Val Ser Met Ser 
    770                 775                 780                 


Thr Leu Tyr Val Leu Ser Leu Arg Thr Glu Glu Asp Leu Val Asp Thr 
785                 790                 795                 800 


Asp Gly Ser Phe Ala Val Ser Thr Ser Cys Leu Leu Ala Leu Leu Arg 
                805                 810                 815     


Pro Gln Pro Pro Gly Gly Ser Glu Ala Leu Cys Pro Trp Ser Ser Gln 
            820                 825                 830         


Ser Phe Gly Thr Thr Gln Leu Arg Gln Ser Pro Leu Thr Thr Gly Leu 
        835                 840                 845             


Pro Gly Ile Gln Pro Ser Leu Leu Leu Val Thr Thr Ser Leu Thr Ser 
    850                 855                 860                 


Ser Ala Pro Gly Ser Ala Val Arg Thr Leu Asp Met Cys Ser Ser His 
865                 870                 875                 880 


Pro Cys Pro Val Ile Cys Cys Ser Ser Pro Thr Thr Asn Pro Thr Thr 
                885                 890                 895     


Gly Pro Ser Leu Gly Pro Ser Phe Asn Pro Gly His Val Leu Ser Pro 
            900                 905                 910         


Ser Pro Ser Pro Ser Thr Asn Arg Ser Gly Pro Ser Gln Met Ala Leu 
        915                 920                 925             


Leu Pro Val Thr Asn Ile Arg Ala Lys Ser Trp Gly Leu Ser Val Asn 
    930                 935                 940                 


Gly Ile Gly His Ser Lys His His Lys Ser Leu Glu Pro Leu Ala Ser 
945                 950                 955                 960 


Pro Ala Val Pro Phe Pro Gly Gly Gln Gly Lys Ala Lys Asn Ser Pro 
                965                 970                 975     


Ser Leu Gly Phe His Gly Arg Ala Arg Arg Gly Ala Leu Gln Ser Ser 
            980                 985                 990         


Val Gly Pro Ala Glu Pro Thr Trp  Ala Gln Gly Gln Ser  Ala Ser Leu 
        995                 1000                 1005             


Leu Ala  Glu Pro Val Pro Ser  Leu Thr Ser Ile Gln  Val Leu Glu 
    1010                 1015                 1020             


Asn Ser  Met Ser Ile Thr Ser  Gln Tyr Cys Ala Pro  Gly Asp Ala 
    1025                 1030                 1035             


Cys Arg  Pro Gly Asn Phe Thr  Tyr His Ile Pro Val  Ser Ser Gly 
    1040                 1045                 1050             


Thr Pro  Leu His Leu Ser Leu  Thr Leu Gln Met Asn  Ser Ser Ser 
    1055                 1060                 1065             


Pro Val  Ser Val Val Leu Cys  Ser Leu Arg Ser Lys  Glu Glu Pro 
    1070                 1075                 1080             


Cys Glu  Glu Gly Ser Leu Pro  Gln Ser Leu His Thr  His Gln Asp 
    1085                 1090                 1095             


Thr Gln  Gly Thr Ser His Arg  Trp Pro Ile Thr Ile  Leu Ser Phe 
    1100                 1105                 1110             


Arg Glu  Phe Thr Tyr His Phe  Arg Val Ala Leu Leu  Gly Gln Ala 
    1115                 1120                 1125             


Asn Cys  Ser Ser Glu Ala Leu  Ala Gln Pro Ala Thr  Asp Tyr His 
    1130                 1135                 1140             


Phe His  Phe Tyr Arg Leu Cys  Asp 
    1145                 1150     


<210>  1324
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  1324

Met Lys Leu Tyr Gly Thr Arg Gly Ser Asp Ile Ser His Phe Gln Cys 
1               5                   10                  15      


Gln Met Leu Gln Ser Ile Ile Lys Asn Ile Trp Ile Pro Met Lys Pro 
            20                  25                  30          


Tyr Tyr Thr Lys Val Tyr Gln Glu Ile Trp Ile Gly Met Gly Leu Met 
        35                  40                  45              


Gly Phe Ile Val Tyr Lys Ile Arg Ala Ala Asp Lys Arg Ser Lys Ala 
    50                  55                  60                  


Leu Lys Ala Ser Ala Pro Ala Pro Gly His His 
65                  70                  75  


<210>  1325
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  1325

Met Ala Leu Val Pro Tyr Glu Glu Thr Thr Glu Phe Gly Leu Gln Lys 
1               5                   10                  15      


Phe His Lys Pro Leu Ala Thr Phe Ser Phe Ala Asn His Thr Ile Gln 
            20                  25                  30          


Ile Arg Gln Asp Trp Arg His Leu Gly Val Ala Ala Val Val Trp Asp 
        35                  40                  45              


Ala Ala Ile Val Leu Ser Thr Tyr Leu Glu Met Gly Ala Val Glu Leu 
    50                  55                  60                  


Arg Gly Arg Ser Ala Val Glu Leu Gly Ala Gly Thr Gly Leu Val Gly 
65                  70                  75                  80  


Ile Val Ala Ala Leu Leu Gly Ala His Val Thr Ile Thr Asp Arg Lys 
                85                  90                  95      


Val Ala Leu Glu Phe Leu Lys Ser Asn Val Gln Ala Asn Leu Pro Pro 
            100                 105                 110         


His Ile Gln Thr Lys Thr Val Val Lys Glu Leu Thr Trp Gly Gln Asn 
        115                 120                 125             


Leu Gly Ser Phe Ser Pro Gly Glu Phe Asp Leu Ile Leu Gly Ala Asp 
    130                 135                 140                 


Ile Ile Tyr Leu Glu Glu Thr Phe Thr Asp Leu Leu Gln Thr Leu Glu 
145                 150                 155                 160 


His Leu Cys Ser Asn His Ser Val Ile Leu Leu Ala Cys Arg Ile Arg 
                165                 170                 175     


Tyr Glu Arg Asp Asn Asn Phe Leu Ala Met Leu Glu Arg Gln Phe Thr 
            180                 185                 190         


Val Arg Lys Val His Tyr Asp Pro Glu Lys Asp Val His Ile Tyr Glu 
        195                 200                 205             


Ala Gln Lys Arg Asn Gln Lys Glu Asp Leu 
    210                 215             


<210>  1326
<211>  590
<212>  PRT
<213>  Homo sapiens

<400>  1326

Met Ala Pro Ser Gly Leu Lys Ala Val Val Gly Glu Lys Ile Leu Ser 
1               5                   10                  15      


Gly Val Ile Arg Ser Val Lys Lys Asp Gly Glu Trp Lys Val Leu Ile 
            20                  25                  30          


Met Asp His Pro Ser Met Arg Ile Leu Ser Ser Cys Cys Lys Met Ser 
        35                  40                  45              


Asp Ile Leu Ala Glu Gly Ile Thr Ile Val Glu Asp Ile Asn Lys Arg 
    50                  55                  60                  


Arg Glu Pro Ile Pro Ser Leu Glu Ala Ile Tyr Leu Leu Ser Pro Thr 
65                  70                  75                  80  


Glu Lys Ala Leu Ile Lys Asp Phe Gln Gly Thr Pro Thr Phe Thr Tyr 
                85                  90                  95      


Lys Ala Ala His Ile Phe Phe Thr Asp Thr Cys Pro Glu Pro Leu Phe 
            100                 105                 110         


Ser Glu Leu Gly Arg Ser Arg Leu Ala Lys Val Val Lys Thr Leu Lys 
        115                 120                 125             


Glu Ile His Leu Ala Phe Leu Pro Tyr Glu Ala Gln Val Phe Ser Leu 
    130                 135                 140                 


Asp Ala Pro His Ser Thr Tyr Asn Leu Tyr Cys Pro Phe Arg Ala Glu 
145                 150                 155                 160 


Glu Arg Thr Arg Gln Leu Glu Val Leu Ala Gln Gln Ile Ala Thr Leu 
                165                 170                 175     


Cys Ala Thr Leu Gln Glu Tyr Pro Ala Ile Arg Tyr Arg Lys Gly Pro 
            180                 185                 190         


Glu Asp Thr Ala Gln Leu Ala His Ala Val Leu Ala Lys Leu Asn Ala 
        195                 200                 205             


Phe Lys Ala Asp Thr Pro Ser Leu Gly Glu Gly Pro Glu Lys Thr Arg 
    210                 215                 220                 


Ser Gln Leu Leu Ile Met Asp Arg Ala Ala Asp Pro Val Ser Pro Leu 
225                 230                 235                 240 


Leu His Glu Leu Thr Phe Gln Ala Met Ala Tyr Asp Leu Leu Asp Ile 
                245                 250                 255     


Glu Gln Asp Thr Tyr Arg Tyr Glu Thr Thr Gly Leu Ser Glu Ala Arg 
            260                 265                 270         


Glu Lys Ala Val Leu Leu Asp Glu Asp Asp Asp Leu Trp Val Glu Leu 
        275                 280                 285             


Arg His Met His Ile Ala Asp Val Ser Lys Lys Val Thr Glu Leu Leu 
    290                 295                 300                 


Arg Thr Phe Cys Glu Ser Lys Arg Leu Thr Thr Asp Lys Ala Asn Ile 
305                 310                 315                 320 


Lys Asp Leu Ser Gln Ile Leu Lys Lys Met Pro Gln Tyr Gln Lys Glu 
                325                 330                 335     


Leu Asn Lys Tyr Ser Thr His Leu His Leu Ala Asp Asp Cys Met Lys 
            340                 345                 350         


His Phe Lys Gly Ser Val Glu Lys Leu Cys Ser Val Glu Gln Asp Leu 
        355                 360                 365             


Ala Met Gly Ser Asp Ala Glu Gly Glu Lys Ile Lys Asp Ser Met Lys 
    370                 375                 380                 


Leu Ile Val Pro Val Leu Leu Asp Ala Ala Val Pro Ala Tyr Asp Lys 
385                 390                 395                 400 


Ile Arg Val Leu Leu Leu Tyr Ile Leu Leu Arg Asn Gly Val Ser Glu 
                405                 410                 415     


Glu Asn Leu Ala Lys Leu Ile Gln His Ala Asn Val Gln Ala His Ser 
            420                 425                 430         


Ser Leu Ile Arg Asn Leu Glu Gln Leu Gly Gly Thr Val Thr Asn Pro 
        435                 440                 445             


Gly Gly Ser Gly Thr Ser Ser Arg Leu Glu Pro Arg Glu Arg Met Glu 
    450                 455                 460                 


Pro Thr Tyr Gln Leu Ser Arg Trp Thr Pro Val Ile Lys Asp Val Met 
465                 470                 475                 480 


Glu Asp Ala Val Glu Asp Arg Leu Asp Arg Asn Leu Trp Pro Phe Val 
                485                 490                 495     


Ser Asp Pro Ala Pro Thr Ala Ser Ser Gln Ala Ala Val Ser Ala Arg 
            500                 505                 510         


Phe Gly His Trp His Lys Asn Lys Ala Gly Ile Glu Ala Arg Ala Gly 
        515                 520                 525             


Pro Arg Leu Ile Val Tyr Val Met Gly Gly Val Ala Met Ser Glu Met 
    530                 535                 540                 


Arg Ala Ala Tyr Glu Val Thr Arg Ala Thr Glu Gly Lys Trp Glu Val 
545                 550                 555                 560 


Leu Ile Gly Ser Ser His Ile Leu Thr Pro Thr Arg Phe Leu Asp Asp 
                565                 570                 575     


Leu Lys Ala Leu Asp Lys Lys Leu Glu Asp Ile Ala Leu Pro 
            580                 585                 590 


<210>  1327
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  1327

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr Asn Asn Thr Ala 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu 
225                 230                 235                 240 


Ser His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro 
                245                 250                 255     


Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser Ser Asp Ile Cys 
            260                 265                 270         


Arg Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn Leu Lys Gly Ile 
        275                 280                 285             


Pro Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe Ala Ser Pro Val 
    290                 295                 300                 


Glu Asn Pro Asp Asn Tyr Cys Phe Cys Thr Glu Lys Ile Ile Ser Lys 
305                 310                 315                 320 


Asn Cys Thr Ser Tyr Gly Val Leu Asp Ile Ser Lys Cys Lys Glu Gly 
                325                 330                 335     


Arg Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr Ala Ser Pro Asp 
            340                 345                 350         


Val Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu Glu Glu His Arg 
        355                 360                 365             


Thr Tyr Leu Asp Ile Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ala 
    370                 375                 380                 


Lys Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser Glu Lys Ile Gln 
385                 390                 395                 400 


Val Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro Ile Leu Trp Leu 
                405                 410                 415     


Asn Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Asn Met Phe Arg Ser 
            420                 425                 430         


Gln Val Thr Gly Lys Ile Asn Leu Leu Gly Leu Ile Glu Met Ile Leu 
        435                 440                 445             


Leu Ser Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys 
    450                 455                 460                 


Ala Cys Arg Ser Lys Thr Ile Lys 
465                 470         


<210>  1328
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  1328

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr Asn Asn Thr Ala 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu 
225                 230                 235                 240 


Ser His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro 
                245                 250                 255     


Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser Ser Asp Ile Cys 
            260                 265                 270         


Arg Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn Leu Lys Gly Ile 
        275                 280                 285             


Pro Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe Ala Ser Pro Val 
    290                 295                 300                 


Glu Asn Pro Asp Asn Tyr Cys Phe Cys Thr Glu Lys Ile Ile Ser Lys 
305                 310                 315                 320 


Asn Cys Thr Ser Tyr Gly Val Leu Asp Ile Ser Lys Cys Lys Glu Gly 
                325                 330                 335     


Arg Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr Ala Ser Pro Asp 
            340                 345                 350         


Val Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu Glu Glu His Arg 
        355                 360                 365             


Thr Tyr Leu Asp Ile Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ala 
    370                 375                 380                 


Lys Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser Glu Lys Ile Gln 
385                 390                 395                 400 


Val Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro Ile Leu Trp Leu 
                405                 410                 415     


Asn Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Asn Met Phe Arg Ser 
            420                 425                 430         


Gln Val Thr Gly Lys Ile Asn Leu Leu Gly Leu Ile Glu Met Ile Leu 
        435                 440                 445             


Leu Ser Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys 
    450                 455                 460                 


Ala Cys Arg Ser Lys Thr Ile Lys 
465                 470         


<210>  1329
<211>  532
<212>  PRT
<213>  Homo sapiens

<400>  1329

Met Pro Ala Pro Pro Gly Arg Thr His Thr Trp Phe Leu Leu Gln Ser 
1               5                   10                  15      


Leu Glu Asp Leu Asp Thr Ser Leu Arg Lys Leu Asn Ser Arg Leu Phe 
            20                  25                  30          


Val Val Arg Gly Gln Pro Ala Asp Val Phe Pro Arg Leu Phe Lys Glu 
        35                  40                  45              


Trp Gly Val Thr Arg Leu Thr Phe Glu Tyr Asp Ser Glu Pro Phe Gly 
    50                  55                  60                  


Lys Glu Arg Asp Ala Ala Ile Met Lys Met Ala Lys Glu Ala Gly Val 
65                  70                  75                  80  


Glu Val Val Thr Glu Asn Ser His Thr Leu Tyr Asp Leu Asp Arg Ile 
                85                  90                  95      


Ile Glu Leu Asn Gly Gln Lys Pro Pro Leu Thr Tyr Lys Arg Phe Gln 
            100                 105                 110         


Ala Ile Ile Ser Arg Met Glu Leu Pro Lys Lys Pro Val Gly Leu Val 
        115                 120                 125             


Thr Ser Gln Gln Met Glu Ser Cys Arg Ala Glu Ile Gln Glu Asn His 
    130                 135                 140                 


Asp Glu Thr Tyr Gly Val Pro Ser Leu Glu Glu Leu Gly Phe Pro Thr 
145                 150                 155                 160 


Glu Gly Leu Gly Pro Ala Val Trp Gln Gly Gly Glu Thr Glu Ala Leu 
                165                 170                 175     


Ala Arg Leu Asp Lys His Leu Glu Arg Lys Ala Trp Val Ala Asn Tyr 
            180                 185                 190         


Glu Arg Pro Arg Met Asn Ala Asn Ser Leu Leu Ala Ser Pro Thr Gly 
        195                 200                 205             


Leu Ser Pro Tyr Leu Arg Phe Gly Cys Leu Ser Cys Arg Leu Phe Tyr 
    210                 215                 220                 


Tyr Arg Leu Trp Asp Leu Tyr Lys Lys Val Lys Arg Asn Ser Thr Pro 
225                 230                 235                 240 


Pro Leu Ser Leu Phe Gly Gln Leu Leu Trp Arg Glu Phe Phe Tyr Thr 
                245                 250                 255     


Ala Ala Thr Asn Asn Pro Arg Phe Asp Arg Met Glu Gly Asn Pro Ile 
            260                 265                 270         


Cys Ile Gln Ile Pro Trp Asp Arg Asn Pro Glu Ala Leu Ala Lys Trp 
        275                 280                 285             


Ala Glu Gly Lys Thr Gly Phe Pro Trp Ile Asp Ala Ile Met Thr Gln 
    290                 295                 300                 


Leu Arg Gln Glu Gly Trp Ile His His Leu Ala Arg His Ala Val Ala 
305                 310                 315                 320 


Cys Phe Leu Thr Arg Gly Asp Leu Trp Val Ser Trp Glu Ser Gly Val 
                325                 330                 335     


Arg Val Phe Asp Glu Leu Leu Leu Asp Ala Asp Phe Ser Val Asn Ala 
            340                 345                 350         


Gly Ser Trp Met Trp Leu Ser Cys Ser Ala Phe Phe Gln Gln Phe Phe 
        355                 360                 365             


His Cys Tyr Cys Pro Val Gly Phe Gly Arg Arg Thr Asp Pro Ser Gly 
    370                 375                 380                 


Asp Tyr Ile Arg Arg Tyr Leu Pro Lys Leu Lys Ala Phe Pro Ser Arg 
385                 390                 395                 400 


Tyr Ile Tyr Glu Pro Trp Asn Ala Pro Glu Ser Ile Gln Lys Ala Ala 
                405                 410                 415     


Lys Cys Ile Ile Gly Val Asp Tyr Pro Arg Pro Ile Val Asn His Ala 
            420                 425                 430         


Glu Thr Ser Arg Leu Asn Ile Glu Arg Met Lys Gln Ile Tyr Gln Gln 
        435                 440                 445             


Leu Ser Arg Tyr Arg Gly Leu Cys Leu Leu Ala Ser Val Pro Ser Cys 
    450                 455                 460                 


Val Glu Asp Leu Ser His Pro Val Ala Glu Pro Ser Ser Ser Gln Ala 
465                 470                 475                 480 


Gly Ser Met Ser Ser Ala Gly Pro Arg Pro Leu Pro Ser Gly Pro Ala 
                485                 490                 495     


Ser Pro Lys Arg Lys Leu Glu Ala Ala Glu Glu Pro Pro Gly Glu Glu 
            500                 505                 510         


Leu Ser Lys Arg Ala Arg Val Ala Glu Leu Pro Thr Pro Glu Leu Pro 
        515                 520                 525             


Ser Lys Asp Ala 
    530         


<210>  1330
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  1330

Met Pro Gln Tyr Glu Asn Pro Trp Thr Ile Pro Asn Met Leu Ser Met 
1               5                   10                  15      


Thr Arg Ile Gly Leu Ala Pro Val Leu Gly Tyr Leu Ile Ile Glu Glu 
            20                  25                  30          


Asp Phe Asn Ile Ala Leu Gly Val Phe Ala Leu Ala Gly Leu Thr Asp 
        35                  40                  45              


Leu Leu Asp Gly Phe Ile Ala Arg Asn Trp Ala Asn Gln Arg Ser Ala 
    50                  55                  60                  


Leu Gly Ser Ala Leu Asp Pro Leu Ala Asp Lys Ile Leu Ile Ser Ile 
65                  70                  75                  80  


Leu Tyr Val Ser Leu Thr Tyr Ala Asp Leu Ile Pro Val Pro Leu Thr 
                85                  90                  95      


Tyr Met Ile Ile Ser Arg Asp Val Met Leu Ile Ala Ala Val Phe Tyr 
            100                 105                 110         


Val Arg Tyr Arg Thr Leu Pro Thr Pro Arg Thr Leu Ala Lys Tyr Phe 
        115                 120                 125             


Asn Pro Cys Tyr Ala Thr Ala Arg Leu Lys Pro Thr Phe Ile Ser Lys 
    130                 135                 140                 


Val Asn Thr Ala Val Gln Leu Ile Leu Val Ala Ala Ser Leu Ala Ala 
145                 150                 155                 160 


Pro Val Phe Asn Tyr Ala Asp Ser Ile Tyr Leu Gln Ile Leu Trp Cys 
                165                 170                 175     


Phe Thr Ala Phe Thr Thr Ala Ala Ser Ala Tyr Ser Tyr Tyr His Tyr 
            180                 185                 190         


Gly Arg Lys Thr Val Gln Val Ile Lys Asp 
        195                 200         


<210>  1331
<211>  769
<212>  PRT
<213>  Homo sapiens

<400>  1331

Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser 
            20                  25                  30          


Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr 
    50                  55                  60                  


Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp 
65                  70                  75                  80  


Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Asp Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asn Asn Ser Asn Gln Phe Gln Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Asn Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Ser Arg Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Ser Asn Val 
            340                 345                 350         


Val His Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Asn Ala Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Gly Val Thr His Arg Asn Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Val Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Ile Val Thr Val Gln Val Leu Pro Gln Cys Glu Cys Arg 
        435                 440                 445             


Cys Arg Asp Gln Ser Arg Asp Arg Ser Leu Cys His Gly Lys Gly Phe 
    450                 455                 460                 


Leu Glu Cys Gly Ile Cys Arg Cys Asp Thr Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Asn Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Val Cys Gly Gln Cys Leu Cys His Thr Ser Asp Val Pro Gly Lys Leu 
        515                 520                 525             


Ile Tyr Gly Gln Tyr Cys Glu Cys Asp Thr Ile Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asn Gly Gln Val Cys Gly Gly Pro Gly Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 


Lys Cys Arg Cys His Pro Gly Phe Glu Gly Ser Ala Cys Gln Cys Glu 
                565                 570                 575     


Arg Thr Thr Glu Gly Cys Leu Asn Pro Arg Arg Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Glu Cys His Ser Gly Tyr Gln 
        595                 600                 605             


Leu Pro Leu Cys Gln Glu Cys Pro Gly Cys Pro Ser Pro Cys Gly Lys 
    610                 615                 620                 


Tyr Ile Ser Cys Ala Glu Cys Leu Lys Phe Glu Lys Gly Pro Phe Gly 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Ala Cys Pro Gly Leu Gln Leu Ser Asn Asn Pro 
                645                 650                 655     


Val Lys Gly Arg Thr Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Val 
            660                 665                 670         


Ala Tyr Thr Leu Glu Gln Gln Asp Gly Met Asp Arg Tyr Leu Ile Tyr 
        675                 680                 685             


Val Asp Glu Ser Arg Glu Cys Val Ala Gly Pro Asn Ile Ala Ala Ile 
    690                 695                 700                 


Val Gly Gly Thr Val Ala Gly Ile Val Leu Ile Gly Ile Leu Leu Leu 
705                 710                 715                 720 


Val Ile Trp Lys Ala Leu Ile His Leu Ser Asp Leu Arg Glu Tyr Arg 
                725                 730                 735     


Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro 
            740                 745                 750         


Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu 
        755                 760                 765             


Ser 
    


<210>  1332
<211>  1408
<212>  PRT
<213>  Homo sapiens

<400>  1332

Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe 
1               5                   10                  15      


Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys 
            20                  25                  30          


Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala 
        35                  40                  45              


Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu 
    50                  55                  60                  


Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys 
65                  70                  75                  80  


Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe 
                85                  90                  95      


Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp 
            100                 105                 110         


Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp 
        115                 120                 125             


Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His 
    130                 135                 140                 


Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys 
145                 150                 155                 160 


Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val 
                165                 170                 175     


Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe 
            180                 185                 190         


Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp 
        195                 200                 205             


His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp 
    210                 215                 220                 


Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu 
225                 230                 235                 240 


Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn 
                245                 250                 255     


Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln 
            260                 265                 270         


Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu 
        275                 280                 285             


His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg 
    290                 295                 300                 


Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala 
305                 310                 315                 320 


Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser 
                325                 330                 335     


Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp 
            340                 345                 350         


Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys 
        355                 360                 365             


Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg 
    370                 375                 380                 


Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg 
385                 390                 395                 400 


Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr 
                405                 410                 415     


Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly 
            420                 425                 430         


Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly 
        435                 440                 445             


Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln 
    450                 455                 460                 


Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu 
465                 470                 475                 480 


Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu 
                485                 490                 495     


Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys 
            500                 505                 510         


Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln 
        515                 520                 525             


Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys 
    530                 535                 540                 


Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile 
545                 550                 555                 560 


Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu 
                565                 570                 575     


Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg 
            580                 585                 590         


Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu 
        595                 600                 605             


Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys 
    610                 615                 620                 


Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile 
625                 630                 635                 640 


Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp 
                645                 650                 655     


Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly 
            660                 665                 670         


Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg 
        675                 680                 685             


His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn 
    690                 695                 700                 


Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe 
705                 710                 715                 720 


Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe 
                725                 730                 735     


Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser 
            740                 745                 750         


Phe Ile Ser Thr Trp Trp Lys Glu Pro Leu Asn Ile Val Ser Phe Leu 
        755                 760                 765             


Phe Cys Phe Ala Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn 
    770                 775                 780                 


Leu Asn Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala 
785                 790                 795                 800 


Gly Arg Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile 
                805                 810                 815     


Ile Cys Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro 
            820                 825                 830         


Leu Lys Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr 
        835                 840                 845             


Phe Asp Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys 
    850                 855                 860                 


Pro Val Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly 
865                 870                 875                 880 


Asn Asp Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly 
                885                 890                 895     


Asn Lys Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys 
            900                 905                 910         


Thr Val Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu 
        915                 920                 925             


Trp Lys Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln 
    930                 935                 940                 


Pro Asp Gln Asn Phe Thr Gly Leu Ile Ala Gly Val Val Ser Ile Ser 
945                 950                 955                 960 


Thr Ala Leu Leu Leu Leu Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg 
                965                 970                 975     


Lys Gln Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg 
            980                 985                 990         


Val His Thr Pro His Leu Asp Arg  Leu Val Ser Ala Arg  Ser Val Ser 
        995                 1000                 1005             


Pro Thr  Thr Glu Met Val Ser  Asn Glu Ser Val Asp  Tyr Arg Ala 
    1010                 1015                 1020             


Thr Phe  Pro Glu Asp Gln Phe  Pro Asn Ser Ser Gln  Asn Gly Ser 
    1025                 1030                 1035             


Cys Arg  Gln Val Gln Tyr Pro  Leu Thr Asp Met Ser  Pro Ile Leu 
    1040                 1045                 1050             


Thr Ser  Gly Asp Ser Asp Ile  Ser Ser Pro Leu Leu  Gln Asn Thr 
    1055                 1060                 1065             


Val His  Ile Asp Leu Ser Ala  Leu Asn Pro Glu Leu  Val Gln Ala 
    1070                 1075                 1080             


Val Gln  His Val Val Ile Gly  Pro Ser Ser Leu Ile  Val His Phe 
    1085                 1090                 1095             


Asn Glu  Val Ile Gly Arg Gly  His Phe Gly Cys Val  Tyr His Gly 
    1100                 1105                 1110             


Thr Leu  Leu Asp Asn Asp Gly  Lys Lys Ile His Cys  Ala Val Lys 
    1115                 1120                 1125             


Ser Leu  Asn Arg Ile Thr Asp  Ile Gly Glu Val Ser  Gln Phe Leu 
    1130                 1135                 1140             


Thr Glu  Gly Ile Ile Met Lys  Asp Phe Ser His Pro  Asn Val Leu 
    1145                 1150                 1155             


Ser Leu  Leu Gly Ile Cys Leu  Arg Ser Glu Gly Ser  Pro Leu Val 
    1160                 1165                 1170             


Val Leu  Pro Tyr Met Lys His  Gly Asp Leu Arg Asn  Phe Ile Arg 
    1175                 1180                 1185             


Asn Glu  Thr His Asn Pro Thr  Val Lys Asp Leu Ile  Gly Phe Gly 
    1190                 1195                 1200             


Leu Gln  Val Ala Lys Gly Met  Lys Tyr Leu Ala Ser  Lys Lys Phe 
    1205                 1210                 1215             


Val His  Arg Asp Leu Ala Ala  Arg Asn Cys Met Leu  Asp Glu Lys 
    1220                 1225                 1230             


Phe Thr  Val Lys Val Ala Asp  Phe Gly Leu Ala Arg  Asp Met Tyr 
    1235                 1240                 1245             


Asp Lys  Glu Tyr Tyr Ser Val  His Asn Lys Thr Gly  Ala Lys Leu 
    1250                 1255                 1260             


Pro Val  Lys Trp Met Ala Leu  Glu Ser Leu Gln Thr  Gln Lys Phe 
    1265                 1270                 1275             


Thr Thr  Lys Ser Asp Val Trp  Ser Phe Gly Val Leu  Leu Trp Glu 
    1280                 1285                 1290             


Leu Met  Thr Arg Gly Ala Pro  Pro Tyr Pro Asp Val  Asn Thr Phe 
    1295                 1300                 1305             


Asp Ile  Thr Val Tyr Leu Leu  Gln Gly Arg Arg Leu  Leu Gln Pro 
    1310                 1315                 1320             


Glu Tyr  Cys Pro Asp Pro Leu  Tyr Glu Val Met Leu  Lys Cys Trp 
    1325                 1330                 1335             


His Pro  Lys Ala Glu Met Arg  Pro Ser Phe Ser Glu  Leu Val Ser 
    1340                 1345                 1350             


Arg Ile  Ser Ala Ile Phe Ser  Thr Phe Ile Gly Glu  His Tyr Val 
    1355                 1360                 1365             


His Val  Asn Ala Thr Tyr Val  Asn Val Lys Cys Val  Ala Pro Tyr 
    1370                 1375                 1380             


Pro Ser  Leu Leu Ser Ser Glu  Asp Asn Ala Asp Asp  Glu Val Asp 
    1385                 1390                 1395             


Thr Arg  Pro Ala Ser Phe Trp  Glu Thr Ser 
    1400                 1405             


<210>  1333
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  1333

Met Met Phe Pro Gln Ser Arg His Ser Gly Ser Ser His Leu Pro Gln 
1               5                   10                  15      


Gln Leu Lys Phe Thr Thr Ser Asp Ser Cys Asp Arg Ile Lys Asp Glu 
            20                  25                  30          


Phe Gln Leu Leu Gln Ala Gln Tyr His Ser Leu Lys Leu Glu Cys Asp 
        35                  40                  45              


Lys Leu Ala Ser Glu Lys Ser Glu Met Gln Arg His Tyr Val Met Tyr 
    50                  55                  60                  


Tyr Glu Met Ser Tyr Gly Leu Asn Ile Glu Met His Lys Gln Ala Glu 
65                  70                  75                  80  


Ile Val Lys Arg Leu Asn Gly Ile Cys Ala Gln Val Leu Pro Tyr Leu 
                85                  90                  95      


Ser Gln Glu His Gln Gln Gln Val Leu Gly Ala Ile Glu Arg Ala Lys 
            100                 105                 110         


Gln Val Thr Ala Pro Glu Leu Asn Ser Ile Ile Arg Gln Gln Leu Gln 
        115                 120                 125             


Ala His Gln Leu Ser Gln Leu Gln Ala Leu Ala Leu Pro Leu Thr Pro 
    130                 135                 140                 


Leu Pro Val Gly Leu Gln Pro Pro Ser Leu Pro Ala Val Ser Ala Gly 
145                 150                 155                 160 


Thr Gly Leu Leu Ser Leu Ser Ala Leu Gly Ser Gln Ala His Leu Ser 
                165                 170                 175     


Lys Glu Asp Lys Asn Gly His Asp Gly Asp Thr His Gln Glu Asp Asp 
            180                 185                 190         


Gly Glu Lys Ser Asp 
        195         


<210>  1334
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  1334

Met Ile Leu Leu Val Asn Leu Phe Val Leu Leu Ser Val Val Cys Val 
1               5                   10                  15      


Leu Leu Asn Leu Ala Gly Phe Ile Leu Gly Cys Gln Gly Ala Gln Phe 
            20                  25                  30          


Val Ser Ser Val Pro Arg Cys Asp Leu Val Asp Leu Gly Glu Gly Lys 
        35                  40                  45              


Ile Cys Phe Cys Cys Glu Glu Phe Gln Pro Ala Lys Cys Thr Asp Lys 
    50                  55                  60                  


Glu Asn Ala Leu Lys Leu Phe Pro Val Gln Pro Cys Ser Ala Val His 
65                  70                  75                  80  


Leu Leu Leu Lys Lys Val Leu Phe Ala Leu Cys Ala Leu Asn Ala Leu 
                85                  90                  95      


Thr Thr Thr Val Cys Leu Val Ala Ala Ala Leu Arg Tyr Leu Gln Ile 
            100                 105                 110         


Phe Ala Thr Arg Arg Ser Cys Ile Asp Glu Ser Gln Ile Ser Ala Glu 
        115                 120                 125             


Glu Ala Glu Asp His Gly Arg Ile Pro Asp Pro Asp Asp Phe Val Pro 
    130                 135                 140                 


Pro Val Pro Pro Pro Ser Tyr Phe Ala Thr Phe Tyr Ser Cys Thr Pro 
145                 150                 155                 160 


Arg Met Asn Arg Arg Met Val Gly Pro Asp Val Ile Pro Leu Pro His 
                165                 170                 175     


Ile Tyr Gly Ala Arg Ile Lys Gly Val Glu Val Phe Cys Pro Leu Asp 
            180                 185                 190         


Pro Pro Pro Pro Tyr Glu Ala Val Val Ser Gln Met Asp Gln Glu Gln 
        195                 200                 205             


Gly Ser Ser Phe Gln Met Ser Glu Gly Ser Glu Ala Ala Val Ile Pro 
    210                 215                 220                 


Leu Asp Leu Gly Cys Thr Gln Val Thr Gln Asp Gly Asp Ile Pro Asn 
225                 230                 235                 240 


Ile Pro Ala Glu Glu Asn Ala Ser Thr Ser Thr Pro Ser Ser Thr Leu 
                245                 250                 255     


Val Arg Pro Ile Arg Ser Arg Arg Ala Leu Pro Pro Leu Arg Thr Arg 
            260                 265                 270         


Ser Lys Ser Asp Pro Val Leu His Pro Ser Glu Glu Arg Ala Ala Pro 
        275                 280                 285             


Val Leu Ser Cys Glu Ala Ala Thr Gln Thr Glu Arg Arg Leu Asp Leu 
    290                 295                 300                 


Ala Ala Val Thr Leu Arg Arg Gly Leu Arg Ser Arg Ala Ser Arg Cys 
305                 310                 315                 320 


Arg Pro Arg Ser Leu Ile Asp Tyr Lys Ser Tyr Met Asp Thr Lys Leu 
                325                 330                 335     


Leu Val Ala Arg Phe Leu Glu Gln Ser Ser Cys Thr Met Thr Pro Asp 
            340                 345                 350         


Ile His Glu Leu Val Glu Asn Ile Lys Ser Val Leu Lys Ser Asp Glu 
        355                 360                 365             


Glu His Met Glu Glu Ala Ile Thr Ser Ala Ser Phe Leu Glu Gln Ile 
    370                 375                 380                 


Met Ala Pro Leu Gln Pro Ser Thr Ser Arg Ala His Lys Leu Pro Ser 
385                 390                 395                 400 


Arg Arg Gln Pro Gly Leu Leu His Leu Gln Ser Cys Gly Asp Leu His 
                405                 410                 415     


Thr Phe Thr Pro Ala Gly Arg Pro Arg Ala Glu Arg Arg Pro Arg Arg 
            420                 425                 430         


Val Glu Ala Glu Arg Pro His Ser Leu Ile Gly Val Ile Arg Glu Thr 
        435                 440                 445             


Val Leu 
    450 


<210>  1335
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  1335

Met Arg Lys Ser Pro Gly Leu Ser Asp Cys Leu Trp Ala Trp Ile Leu 
1               5                   10                  15      


Leu Leu Ser Thr Leu Thr Gly Arg Ser Tyr Gly Gln Pro Ser Leu Gln 
            20                  25                  30          


Asp Glu Leu Lys Asp Asn Thr Thr Val Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Glu Arg 
    50                  55                  60                  


Val Thr Glu Val Lys Thr Asp Ile Phe Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp His Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Ser 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Thr Val Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Thr Glu Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Arg Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ala Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Arg Ala 
            180                 185                 190         


Glu Val Val Tyr Glu Trp Thr Arg Glu Pro Ala Arg Ser Val Val Val 
        195                 200                 205             


Ala Glu Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Thr 
    210                 215                 220                 


Val Asp Ser Gly Ile Val Gln Ser Ser Thr Gly Glu Tyr Val Val Met 
225                 230                 235                 240 


Thr Thr His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285             


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300                 


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320 


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335     


Phe Thr Lys Arg Gly Tyr Ala Trp Asp Gly Lys Ser Val Val Pro Glu 
            340                 345                 350         


Lys Pro Lys Lys Val Lys Asp Pro Leu Ile Lys Lys Asn Asn Thr Tyr 
        355                 360                 365             


Ala Pro Thr Ala Thr Ser Tyr Thr Pro Asn Leu Ala Arg Gly Asp Pro 
    370                 375                 380                 


Gly Leu Ala Thr Ile Ala Lys Ser Ala Thr Ile Glu Pro Lys Glu Val 
385                 390                 395                 400 


Lys Pro Glu Thr Lys Pro Pro Glu Pro Lys Lys Thr Phe Asn Ser Val 
                405                 410                 415     


Ser Lys Ile Asp Arg Leu Ser Arg Ile Ala Phe Pro Leu Leu Phe Gly 
            420                 425                 430         


Ile Phe Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Gln 
        435                 440                 445             


Leu Lys Ala Pro Thr Pro His Gln 
    450                 455     


<210>  1336
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  1336

Met Arg Lys Ser Pro Gly Leu Ser Asp Cys Leu Trp Ala Trp Ile Leu 
1               5                   10                  15      


Leu Leu Ser Thr Leu Thr Gly Arg Ser Tyr Gly Gln Pro Ser Leu Gln 
            20                  25                  30          


Asp Glu Leu Lys Asp Asn Thr Thr Val Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Glu Arg 
    50                  55                  60                  


Val Thr Glu Val Lys Thr Asp Ile Phe Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp His Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Ser 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Thr Val Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Thr Glu Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Arg Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ala Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Arg Ala 
            180                 185                 190         


Glu Val Val Tyr Glu Trp Thr Arg Glu Pro Ala Arg Ser Val Val Val 
        195                 200                 205             


Ala Glu Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Thr 
    210                 215                 220                 


Val Asp Ser Gly Ile Val Gln Ser Ser Thr Gly Glu Tyr Val Val Met 
225                 230                 235                 240 


Thr Thr His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285             


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300                 


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320 


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335     


Phe Thr Lys Arg Gly Tyr Ala Trp Asp Gly Lys Ser Val Val Pro Glu 
            340                 345                 350         


Lys Pro Lys Lys Val Lys Asp Pro Leu Ile Lys Lys Asn Asn Thr Tyr 
        355                 360                 365             


Ala Pro Thr Ala Thr Ser Tyr Thr Pro Asn Leu Ala Arg Gly Asp Pro 
    370                 375                 380                 


Gly Leu Ala Thr Ile Ala Lys Ser Ala Thr Ile Glu Pro Lys Glu Val 
385                 390                 395                 400 


Lys Pro Glu Thr Lys Pro Pro Glu Pro Lys Lys Thr Phe Asn Ser Val 
                405                 410                 415     


Ser Lys Ile Asp Arg Leu Ser Arg Ile Ala Phe Pro Leu Leu Phe Gly 
            420                 425                 430         


Ile Phe Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Gln 
        435                 440                 445             


Leu Lys Ala Pro Thr Pro His Gln 
    450                 455     


<210>  1337
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  1337

Met Arg Lys Ser Pro Gly Leu Ser Asp Cys Leu Trp Ala Trp Ile Leu 
1               5                   10                  15      


Leu Leu Ser Thr Leu Thr Gly Arg Ser Tyr Gly Gln Pro Ser Leu Gln 
            20                  25                  30          


Asp Glu Leu Lys Asp Asn Thr Thr Val Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Glu Arg 
    50                  55                  60                  


Val Thr Glu Val Lys Thr Asp Ile Phe Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp His Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Ser 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Thr Val Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Thr Glu Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Arg Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ala Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Arg Ala 
            180                 185                 190         


Glu Val Val Tyr Glu Trp Thr Arg Glu Pro Ala Arg Ser Val Val Val 
        195                 200                 205             


Ala Glu Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Thr 
    210                 215                 220                 


Val Asp Ser Gly Ile Val Gln Ser Ser Thr Gly Glu Tyr Val Val Met 
225                 230                 235                 240 


Thr Thr His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285             


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300                 


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320 


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335     


Phe Thr Lys Arg Gly Tyr Ala Trp Asp Gly Lys Ser Val Val Pro Glu 
            340                 345                 350         


Lys Pro Lys Lys Val Lys Asp Pro Leu Ile Lys Lys Asn Asn Thr Tyr 
        355                 360                 365             


Ala Pro Thr Ala Thr Ser Tyr Thr Pro Asn Leu Ala Arg Gly Asp Pro 
    370                 375                 380                 


Gly Leu Ala Thr Ile Ala Lys Ser Ala Thr Ile Glu Pro Lys Glu Val 
385                 390                 395                 400 


Lys Pro Glu Thr Lys Pro Pro Glu Pro Lys Lys Thr Phe Asn Ser Val 
                405                 410                 415     


Ser Lys Ile Asp Arg Leu Ser Arg Ile Ala Phe Pro Leu Leu Phe Gly 
            420                 425                 430         


Ile Phe Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Gln 
        435                 440                 445             


Leu Lys Ala Pro Thr Pro His Gln 
    450                 455     


<210>  1338
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  1338

Met Arg Lys Ser Pro Gly Leu Ser Asp Cys Leu Trp Ala Trp Ile Leu 
1               5                   10                  15      


Leu Leu Ser Thr Leu Thr Gly Arg Ser Tyr Gly Gln Pro Ser Leu Gln 
            20                  25                  30          


Asp Glu Leu Lys Asp Asn Thr Thr Val Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Glu Arg 
    50                  55                  60                  


Val Thr Glu Val Lys Thr Asp Ile Phe Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp His Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Ser 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Thr Val Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Thr Glu Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Arg Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ala Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Arg Ala 
            180                 185                 190         


Glu Val Val Tyr Glu Trp Thr Arg Glu Pro Ala Arg Ser Val Val Val 
        195                 200                 205             


Ala Glu Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Thr 
    210                 215                 220                 


Val Asp Ser Gly Ile Val Gln Ser Ser Thr Gly Glu Tyr Val Val Met 
225                 230                 235                 240 


Thr Thr His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285             


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300                 


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320 


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335     


Phe Thr Lys Arg Gly Tyr Ala Trp Asp Gly Lys Ser Val Val Pro Glu 
            340                 345                 350         


Lys Pro Lys Lys Val Lys Asp Pro Leu Ile Lys Lys Asn Asn Thr Tyr 
        355                 360                 365             


Ala Pro Thr Ala Thr Ser Tyr Thr Pro Asn Leu Ala Arg Gly Asp Pro 
    370                 375                 380                 


Gly Leu Ala Thr Ile Ala Lys Ser Ala Thr Ile Glu Pro Lys Glu Val 
385                 390                 395                 400 


Lys Pro Glu Thr Lys Pro Pro Glu Pro Lys Lys Thr Phe Asn Ser Val 
                405                 410                 415     


Ser Lys Ile Asp Arg Leu Ser Arg Ile Ala Phe Pro Leu Leu Phe Gly 
            420                 425                 430         


Ile Phe Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Gln 
        435                 440                 445             


Leu Lys Ala Pro Thr Pro His Gln 
    450                 455     


<210>  1339
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  1339

Met Arg Lys Ser Pro Gly Leu Ser Asp Cys Leu Trp Ala Trp Ile Leu 
1               5                   10                  15      


Leu Leu Ser Thr Leu Thr Gly Arg Ser Tyr Gly Gln Pro Ser Leu Gln 
            20                  25                  30          


Asp Glu Leu Lys Asp Asn Thr Thr Val Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Glu Arg 
    50                  55                  60                  


Val Thr Glu Val Lys Thr Asp Ile Phe Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp His Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Ser 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Thr Val Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Thr Glu Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Arg Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ala Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Arg Ala 
            180                 185                 190         


Glu Val Val Tyr Glu Trp Thr Arg Glu Pro Ala Arg Ser Val Val Val 
        195                 200                 205             


Ala Glu Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Thr 
    210                 215                 220                 


Val Asp Ser Gly Ile Val Gln Ser Ser Thr Gly Glu Tyr Val Val Met 
225                 230                 235                 240 


Thr Thr His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285             


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300                 


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320 


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335     


Phe Thr Lys Arg Gly Tyr Ala Trp Asp Gly Lys Ser Val Val Pro Glu 
            340                 345                 350         


Lys Pro Lys Lys Val Lys Asp Pro Leu Ile Lys Lys Asn Asn Thr Tyr 
        355                 360                 365             


Ala Pro Thr Ala Thr Ser Tyr Thr Pro Asn Leu Ala Arg Gly Asp Pro 
    370                 375                 380                 


Gly Leu Ala Thr Ile Ala Lys Ser Ala Thr Ile Glu Pro Lys Glu Val 
385                 390                 395                 400 


Lys Pro Glu Thr Lys Pro Pro Glu Pro Lys Lys Thr Phe Asn Ser Val 
                405                 410                 415     


Ser Lys Ile Asp Arg Leu Ser Arg Ile Ala Phe Pro Leu Leu Phe Gly 
            420                 425                 430         


Ile Phe Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Gln 
        435                 440                 445             


Leu Lys Ala Pro Thr Pro His Gln 
    450                 455     


<210>  1340
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  1340

Met Arg Lys Ser Pro Gly Leu Ser Asp Cys Leu Trp Ala Trp Ile Leu 
1               5                   10                  15      


Leu Leu Ser Thr Leu Thr Gly Arg Ser Tyr Gly Gln Pro Ser Leu Gln 
            20                  25                  30          


Asp Glu Leu Lys Asp Asn Thr Thr Val Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Glu Arg 
    50                  55                  60                  


Val Thr Glu Val Lys Thr Asp Ile Phe Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp His Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Ser 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Thr Val Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Thr Glu Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Arg Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ala Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Arg Ala 
            180                 185                 190         


Glu Val Val Tyr Glu Trp Thr Arg Glu Pro Ala Arg Ser Val Val Val 
        195                 200                 205             


Ala Glu Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Thr 
    210                 215                 220                 


Val Asp Ser Gly Ile Val Gln Ser Ser Thr Gly Glu Tyr Val Val Met 
225                 230                 235                 240 


Thr Thr His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285             


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300                 


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320 


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335     


Phe Thr Lys Arg Gly Tyr Ala Trp Asp Gly Lys Ser Val Val Pro Glu 
            340                 345                 350         


Lys Pro Lys Lys Val Lys Asp Pro Leu Ile Lys Lys Asn Asn Thr Tyr 
        355                 360                 365             


Ala Pro Thr Ala Thr Ser Tyr Thr Pro Asn Leu Ala Arg Gly Asp Pro 
    370                 375                 380                 


Gly Leu Ala Thr Ile Ala Lys Ser Ala Thr Ile Glu Pro Lys Glu Val 
385                 390                 395                 400 


Lys Pro Glu Thr Lys Pro Pro Glu Pro Lys Lys Thr Phe Asn Ser Val 
                405                 410                 415     


Ser Lys Ile Asp Arg Leu Ser Arg Ile Ala Phe Pro Leu Leu Phe Gly 
            420                 425                 430         


Ile Phe Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Gln 
        435                 440                 445             


Leu Lys Ala Pro Thr Pro His Gln 
    450                 455     


<210>  1341
<211>  757
<212>  PRT
<213>  Homo sapiens

<400>  1341

Met Ser Leu Leu Phe Ser Arg Cys Asn Ser Ile Val Thr Val Lys Lys 
1               5                   10                  15      


Asn Lys Arg His Met Ala Glu Val Asn Ala Ser Pro Leu Lys His Phe 
            20                  25                  30          


Val Thr Ala Lys Lys Lys Ile Asn Gly Ile Phe Glu Gln Leu Gly Ala 
        35                  40                  45              


Tyr Ile Gln Glu Ser Ala Thr Phe Leu Glu Asp Thr Tyr Arg Asn Ala 
    50                  55                  60                  


Glu Leu Asp Pro Val Thr Thr Glu Glu Gln Val Leu Asp Val Lys Gly 
65                  70                  75                  80  


Tyr Leu Ser Lys Val Arg Gly Ile Ser Glu Val Leu Ala Arg Arg His 
                85                  90                  95      


Met Lys Val Ala Phe Phe Gly Arg Thr Ser Asn Gly Lys Ser Thr Val 
            100                 105                 110         


Ile Asn Ala Met Leu Trp Asp Lys Val Leu Pro Ser Gly Ile Gly His 
        115                 120                 125             


Thr Thr Asn Cys Phe Leu Arg Val Glu Gly Thr Asp Gly His Glu Ala 
    130                 135                 140                 


Phe Leu Leu Thr Glu Gly Ser Glu Glu Lys Arg Ser Ala Lys Thr Val 
145                 150                 155                 160 


Asn Gln Leu Ala His Ala Leu His Gln Asp Lys Gln Leu His Ala Gly 
                165                 170                 175     


Ser Leu Val Ser Val Met Trp Pro Asn Ser Lys Cys Pro Leu Leu Lys 
            180                 185                 190         


Asp Asp Leu Val Leu Met Asp Ser Pro Gly Ile Asp Val Thr Thr Glu 
        195                 200                 205             


Leu Asp Ser Trp Ile Asp Lys Phe Cys Leu Asp Ala Asp Val Phe Val 
    210                 215                 220                 


Leu Val Ala Asn Ser Glu Ser Thr Leu Met Gln Thr Glu Lys His Phe 
225                 230                 235                 240 


Phe His Lys Val Ser Glu Arg Leu Ser Arg Pro Asn Ile Phe Ile Leu 
                245                 250                 255     


Asn Asn Arg Trp Asp Ala Ser Ala Ser Glu Pro Glu Tyr Met Glu Glu 
            260                 265                 270         


Val Arg Arg Gln His Met Glu Arg Cys Thr Ser Phe Leu Val Asp Glu 
        275                 280                 285             


Leu Gly Val Val Asp Arg Ser Gln Ala Gly Asp Arg Ile Phe Phe Val 
    290                 295                 300                 


Ser Ala Lys Glu Val Leu Asn Ala Arg Ile Gln Lys Ala Gln Gly Met 
305                 310                 315                 320 


Pro Glu Gly Gly Gly Ala Leu Ala Glu Gly Phe Gln Val Arg Met Phe 
                325                 330                 335     


Glu Phe Gln Asn Phe Glu Arg Arg Phe Glu Glu Cys Ile Ser Gln Ser 
            340                 345                 350         


Ala Val Lys Thr Lys Phe Glu Gln His Thr Val Arg Ala Lys Gln Ile 
        355                 360                 365             


Ala Glu Ala Val Arg Leu Ile Met Asp Ser Leu His Met Ala Ala Arg 
    370                 375                 380                 


Glu Gln Gln Val Tyr Cys Glu Glu Met Arg Glu Glu Arg Gln Asp Arg 
385                 390                 395                 400 


Leu Lys Phe Ile Asp Lys Gln Leu Glu Leu Leu Ala Gln Asp Tyr Lys 
                405                 410                 415     


Leu Arg Ile Lys Gln Ile Thr Glu Glu Val Glu Arg Gln Val Ser Thr 
            420                 425                 430         


Ala Met Ala Glu Glu Ile Arg Arg Leu Ser Val Leu Val Asp Asp Tyr 
        435                 440                 445             


Gln Met Asp Phe His Pro Ser Pro Val Val Leu Lys Val Tyr Lys Asn 
    450                 455                 460                 


Glu Leu His Arg His Ile Glu Glu Gly Leu Gly Arg Asn Met Ser Asp 
465                 470                 475                 480 


Arg Cys Ser Thr Ala Ile Thr Asn Ser Leu Gln Thr Met Gln Gln Asp 
                485                 490                 495     


Met Ile Asp Gly Leu Lys Pro Leu Leu Pro Val Ser Val Arg Ser Gln 
            500                 505                 510         


Ile Asp Met Leu Val Pro Arg Gln Cys Phe Ser Leu Asn Tyr Asp Leu 
        515                 520                 525             


Asn Cys Asp Lys Leu Cys Ala Asp Phe Gln Glu Asp Ile Glu Phe His 
    530                 535                 540                 


Phe Ser Leu Gly Trp Thr Met Leu Val Asn Arg Phe Leu Gly Pro Lys 
545                 550                 555                 560 


Asn Ser Arg Arg Ala Leu Met Gly Tyr Asn Asp Gln Val Gln Arg Pro 
                565                 570                 575     


Ile Pro Leu Thr Pro Ala Asn Pro Ser Met Pro Pro Leu Pro Gln Gly 
            580                 585                 590         


Ser Leu Thr Gln Glu Glu Phe Met Val Ser Met Val Thr Gly Leu Ala 
        595                 600                 605             


Ser Leu Thr Ser Arg Thr Ser Met Gly Ile Leu Val Val Gly Gly Val 
    610                 615                 620                 


Val Trp Lys Ala Val Gly Trp Arg Leu Ile Ala Leu Ser Phe Gly Leu 
625                 630                 635                 640 


Tyr Gly Leu Leu Tyr Val Tyr Glu Arg Leu Thr Trp Thr Thr Lys Ala 
                645                 650                 655     


Lys Glu Arg Ala Phe Lys Arg Gln Phe Val Glu His Ala Ser Glu Lys 
            660                 665                 670         


Leu Gln Leu Val Ile Ser Tyr Thr Gly Ser Asn Cys Ser His Gln Val 
        675                 680                 685             


Gln Gln Glu Leu Ser Gly Thr Phe Ala His Leu Cys Gln Gln Val Asp 
    690                 695                 700                 


Val Thr Arg Glu Asn Leu Glu Gln Glu Ile Ala Ala Met Asn Lys Lys 
705                 710                 715                 720 


Ile Glu Val Leu Asp Ser Leu Gln Ser Lys Ala Lys Leu Leu Arg Asn 
                725                 730                 735     


Lys Ala Gly Trp Leu Asp Ser Glu Leu Asn Met Phe Thr His Gln Tyr 
            740                 745                 750         


Leu Gln Pro Ser Arg 
        755         


<210>  1342
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  1342

Met Ile Leu Ser Asn Thr Thr Ala Val Thr Pro Phe Leu Thr Lys Leu 
1               5                   10                  15      


Trp Gln Glu Thr Val Gln Gln Gly Gly Asn Met Ser Gly Leu Ala Arg 
            20                  25                  30          


Arg Ser Pro Arg Ser Ser Asp Gly Lys Leu Glu Ala Leu Tyr Val Leu 
        35                  40                  45              


Met Val Leu Gly Phe Phe Gly Phe Phe Thr Leu Gly Ile Met Leu Ser 
    50                  55                  60                  


Tyr Ile Arg Ser Lys Lys Leu Glu His Ser Asn Asp Pro Phe Asn Val 
65                  70                  75                  80  


Tyr Ile Glu Ser Asp Ala Trp Gln Glu Lys Asp Lys Ala Tyr Val Gln 
                85                  90                  95      


Ala Arg Val Leu Glu Ser Tyr Arg Ser Cys Tyr Val Val Glu Asn His 
            100                 105                 110         


Leu Ala Ile Glu Gln Pro Asn Thr His Leu Pro Glu Thr Lys Pro Ser 
        115                 120                 125             


Pro 
    


<210>  1343
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  1343

Met Ile Leu Ser Asn Thr Thr Ala Val Thr Pro Phe Leu Thr Lys Leu 
1               5                   10                  15      


Trp Gln Glu Thr Val Gln Gln Gly Gly Asn Met Ser Gly Leu Ala Arg 
            20                  25                  30          


Arg Ser Pro Arg Ser Ser Asp Gly Lys Leu Glu Ala Leu Tyr Val Leu 
        35                  40                  45              


Met Val Leu Gly Phe Phe Gly Phe Phe Thr Leu Gly Ile Met Leu Ser 
    50                  55                  60                  


Tyr Ile Arg Ser Lys Lys Leu Glu His Ser Asn Asp Pro Phe Asn Val 
65                  70                  75                  80  


Tyr Ile Glu Ser Asp Ala Trp Gln Glu Lys Asp Lys Ala Tyr Val Gln 
                85                  90                  95      


Ala Arg Val Leu Glu Ser Tyr Arg Ser Cys Tyr Val Val Glu Asn His 
            100                 105                 110         


Leu Ala Ile Glu Gln Pro Asn Thr His Leu Pro Glu Thr Lys Pro Ser 
        115                 120                 125             


Pro 
    


<210>  1344
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  1344

Met Ile Leu Ser Asn Thr Thr Ala Val Thr Pro Phe Leu Thr Lys Leu 
1               5                   10                  15      


Trp Gln Glu Thr Val Gln Gln Gly Gly Asn Met Ser Gly Leu Ala Arg 
            20                  25                  30          


Arg Ser Pro Arg Ser Ser Asp Gly Lys Leu Glu Ala Leu Tyr Val Leu 
        35                  40                  45              


Met Val Leu Gly Phe Phe Gly Phe Phe Thr Leu Gly Ile Met Leu Ser 
    50                  55                  60                  


Tyr Ile Arg Ser Lys Lys Leu Glu His Ser Asn Asp Pro Phe Asn Val 
65                  70                  75                  80  


Tyr Ile Glu Ser Asp Ala Trp Gln Glu Lys Asp Lys Ala Tyr Val Gln 
                85                  90                  95      


Ala Arg Val Leu Glu Ser Tyr Arg Ser Cys Tyr Val Val Glu Asn His 
            100                 105                 110         


Leu Ala Ile Glu Gln Pro Asn Thr His Leu Pro Glu Thr Lys Pro Ser 
        115                 120                 125             


Pro 
    


<210>  1345
<211>  1097
<212>  PRT
<213>  Homo sapiens

<400>  1345

Met Met Asp Ile Tyr Val Cys Leu Lys Arg Pro Ser Trp Met Val Asp 
1               5                   10                  15      


Asn Lys Arg Met Arg Thr Ala Ser Asn Phe Gln Trp Leu Leu Ser Thr 
            20                  25                  30          


Phe Ile Leu Leu Tyr Leu Met Asn Gln Val Asn Ser Gln Lys Lys Gly 
        35                  40                  45              


Ala Pro His Asp Leu Lys Cys Val Thr Asn Asn Leu Gln Val Trp Asn 
    50                  55                  60                  


Cys Ser Trp Lys Ala Pro Ser Gly Thr Gly Arg Gly Thr Asp Tyr Glu 
65                  70                  75                  80  


Val Cys Ile Glu Asn Arg Ser Arg Ser Cys Tyr Gln Leu Glu Lys Thr 
                85                  90                  95      


Ser Ile Lys Ile Pro Ala Leu Ser His Gly Asp Tyr Glu Ile Thr Ile 
            100                 105                 110         


Asn Ser Leu His Asp Phe Gly Ser Ser Thr Ser Lys Phe Thr Leu Asn 
        115                 120                 125             


Glu Gln Asn Val Ser Leu Ile Pro Asp Thr Pro Glu Ile Leu Asn Leu 
    130                 135                 140                 


Ser Ala Asp Phe Ser Thr Ser Thr Leu Tyr Leu Lys Trp Asn Asp Arg 
145                 150                 155                 160 


Gly Ser Val Phe Pro His Arg Ser Asn Val Ile Trp Glu Ile Lys Val 
                165                 170                 175     


Leu Arg Lys Glu Ser Met Glu Leu Val Lys Leu Val Thr His Asn Thr 
            180                 185                 190         


Thr Leu Asn Gly Lys Asp Thr Leu His His Trp Ser Trp Ala Ser Asp 
        195                 200                 205             


Met Pro Leu Glu Cys Ala Ile His Phe Val Glu Ile Arg Cys Tyr Ile 
    210                 215                 220                 


Asp Asn Leu His Phe Ser Gly Leu Glu Glu Trp Ser Asp Trp Ser Pro 
225                 230                 235                 240 


Val Lys Asn Ile Ser Trp Ile Pro Asp Ser Gln Thr Lys Val Phe Pro 
                245                 250                 255     


Gln Asp Lys Val Ile Leu Val Gly Ser Asp Ile Thr Phe Cys Cys Val 
            260                 265                 270         


Ser Gln Glu Lys Val Leu Ser Ala Leu Ile Gly His Thr Asn Cys Pro 
        275                 280                 285             


Leu Ile His Leu Asp Gly Glu Asn Val Ala Ile Lys Ile Arg Asn Ile 
    290                 295                 300                 


Ser Val Ser Ala Ser Ser Gly Thr Asn Val Val Phe Thr Thr Glu Asp 
305                 310                 315                 320 


Asn Ile Phe Gly Thr Val Ile Phe Ala Gly Tyr Pro Pro Asp Thr Pro 
                325                 330                 335     


Gln Gln Leu Asn Cys Glu Thr His Asp Leu Lys Glu Ile Ile Cys Ser 
            340                 345                 350         


Trp Asn Pro Gly Arg Val Thr Ala Leu Val Gly Pro Arg Ala Thr Ser 
        355                 360                 365             


Tyr Thr Leu Val Glu Ser Phe Ser Gly Lys Tyr Val Arg Leu Lys Arg 
    370                 375                 380                 


Ala Glu Ala Pro Thr Asn Glu Ser Tyr Gln Leu Leu Phe Gln Met Leu 
385                 390                 395                 400 


Pro Asn Gln Glu Ile Tyr Asn Phe Thr Leu Asn Ala His Asn Pro Leu 
                405                 410                 415     


Gly Arg Ser Gln Ser Thr Ile Leu Val Asn Ile Thr Glu Lys Val Tyr 
            420                 425                 430         


Pro His Thr Pro Thr Ser Phe Lys Val Lys Asp Ile Asn Ser Thr Ala 
        435                 440                 445             


Val Lys Leu Ser Trp His Leu Pro Gly Asn Phe Ala Lys Ile Asn Phe 
    450                 455                 460                 


Leu Cys Glu Ile Glu Ile Lys Lys Ser Asn Ser Val Gln Glu Gln Arg 
465                 470                 475                 480 


Asn Val Thr Ile Lys Gly Val Glu Asn Ser Ser Tyr Leu Val Ala Leu 
                485                 490                 495     


Asp Lys Leu Asn Pro Tyr Thr Leu Tyr Thr Phe Arg Ile Arg Cys Ser 
            500                 505                 510         


Thr Glu Thr Phe Trp Lys Trp Ser Lys Trp Ser Asn Lys Lys Gln His 
        515                 520                 525             


Leu Thr Thr Glu Ala Ser Pro Ser Lys Gly Pro Asp Thr Trp Arg Glu 
    530                 535                 540                 


Trp Ser Ser Asp Gly Lys Asn Leu Ile Ile Tyr Trp Lys Pro Leu Pro 
545                 550                 555                 560 


Ile Asn Glu Ala Asn Gly Lys Ile Leu Ser Tyr Asn Val Ser Cys Ser 
                565                 570                 575     


Ser Asp Glu Glu Thr Gln Ser Leu Ser Glu Ile Pro Asp Pro Gln His 
            580                 585                 590         


Lys Ala Glu Ile Arg Leu Asp Lys Asn Asp Tyr Ile Ile Ser Val Val 
        595                 600                 605             


Ala Lys Asn Ser Val Gly Ser Ser Pro Pro Ser Lys Ile Ala Ser Met 
    610                 615                 620                 


Glu Ile Pro Asn Asp Asp Leu Lys Ile Glu Gln Val Val Gly Met Gly 
625                 630                 635                 640 


Lys Gly Ile Leu Leu Thr Trp His Tyr Asp Pro Asn Met Thr Cys Asp 
                645                 650                 655     


Tyr Val Ile Lys Trp Cys Asn Ser Ser Arg Ser Glu Pro Cys Leu Met 
            660                 665                 670         


Asp Trp Arg Lys Val Pro Ser Asn Ser Thr Glu Thr Val Ile Glu Ser 
        675                 680                 685             


Asp Glu Phe Arg Pro Gly Ile Arg Tyr Asn Phe Phe Leu Tyr Gly Cys 
    690                 695                 700                 


Arg Asn Gln Gly Tyr Gln Leu Leu Arg Ser Met Ile Gly Tyr Ile Glu 
705                 710                 715                 720 


Glu Leu Ala Pro Ile Val Ala Pro Asn Phe Thr Val Glu Asp Thr Ser 
                725                 730                 735     


Ala Asp Ser Ile Leu Val Lys Trp Glu Asp Ile Pro Val Glu Glu Leu 
            740                 745                 750         


Arg Gly Phe Leu Arg Gly Tyr Leu Phe Tyr Phe Gly Lys Gly Glu Arg 
        755                 760                 765             


Asp Thr Ser Lys Met Arg Val Leu Glu Ser Gly Arg Ser Asp Ile Lys 
    770                 775                 780                 


Val Lys Asn Ile Thr Asp Ile Ser Gln Lys Thr Leu Arg Ile Ala Asp 
785                 790                 795                 800 


Leu Gln Gly Lys Thr Ser Tyr His Leu Val Leu Arg Ala Tyr Thr Asp 
                805                 810                 815     


Gly Gly Val Gly Pro Glu Lys Ser Met Tyr Val Val Thr Lys Glu Asn 
            820                 825                 830         


Ser Val Gly Leu Ile Ile Ala Ile Leu Ile Pro Val Ala Val Ala Val 
        835                 840                 845             


Ile Val Gly Val Val Thr Ser Ile Leu Cys Tyr Arg Lys Arg Glu Trp 
    850                 855                 860                 


Ile Lys Glu Thr Phe Tyr Pro Asp Ile Pro Asn Pro Glu Asn Cys Lys 
865                 870                 875                 880 


Ala Leu Gln Phe Gln Lys Ser Val Cys Glu Gly Ser Ser Ala Leu Lys 
                885                 890                 895     


Thr Leu Glu Met Asn Pro Cys Thr Pro Asn Asn Val Glu Val Leu Glu 
            900                 905                 910         


Thr Arg Ser Ala Phe Pro Lys Ile Glu Asp Thr Glu Ile Ile Ser Pro 
        915                 920                 925             


Val Ala Glu Arg Pro Glu Asp Arg Ser Asp Ala Glu Pro Glu Asn His 
    930                 935                 940                 


Val Val Val Ser Tyr Cys Pro Pro Ile Ile Glu Glu Glu Ile Pro Asn 
945                 950                 955                 960 


Pro Ala Ala Asp Glu Ala Gly Gly Thr Ala Gln Val Ile Tyr Ile Asp 
                965                 970                 975     


Val Gln Ser Met Tyr Gln Pro Gln Ala Lys Pro Glu Glu Glu Gln Glu 
            980                 985                 990         


Asn Asp Pro Val Gly Gly Ala Gly  Tyr Lys Pro Gln Met  His Leu Pro 
        995                 1000                 1005             


Ile Asn  Ser Thr Val Glu Asp  Ile Ala Ala Glu Glu  Asp Leu Asp 
    1010                 1015                 1020             


Lys Thr  Ala Gly Tyr Arg Pro  Gln Ala Asn Val Asn  Thr Trp Asn 
    1025                 1030                 1035             


Leu Val  Ser Pro Asp Ser Pro  Arg Ser Ile Asp Ser  Asn Ser Glu 
    1040                 1045                 1050             


Ile Val  Ser Phe Gly Ser Pro  Cys Ser Ile Asn Ser  Arg Gln Phe 
    1055                 1060                 1065             


Leu Ile  Pro Pro Lys Asp Glu  Asp Ser Pro Lys Ser  Asn Gly Gly 
    1070                 1075                 1080             


Gly Trp  Ser Phe Thr Asn Phe  Phe Gln Asn Lys Pro  Asn Asp 
    1085                 1090                 1095         


<210>  1346
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  1346

Met Ser Ser His Lys Gly Ser Val Val Ala Gln Gly Asn Gly Ala Pro 
1               5                   10                  15      


Ala Ser Asn Arg Glu Ala Asp Thr Val Glu Leu Ala Glu Leu Gly Pro 
            20                  25                  30          


Leu Leu Glu Glu Lys Gly Lys Arg Val Ile Ala Asn Pro Pro Lys Ala 
        35                  40                  45              


Glu Glu Glu Gln Thr Cys Pro Val Pro Gln Glu Glu Glu Glu Glu Val 
    50                  55                  60                  


Arg Val Leu Thr Leu Pro Leu Gln Ala His His Ala Met Glu Lys Met 
65                  70                  75                  80  


Glu Glu Phe Val Tyr Lys Val Trp Glu Gly Arg Trp Arg Val Ile Pro 
                85                  90                  95      


Tyr Asp Val Leu Pro Asp Trp Leu Lys Asp Asn Asp Tyr Leu Leu His 
            100                 105                 110         


Gly His Arg Pro Pro Met Pro Ser Phe Arg Ala Cys Phe Lys Ser Ile 
        115                 120                 125             


Phe Arg Ile His Thr Glu Thr Gly Asn Ile Trp Thr His Leu Leu Gly 
    130                 135                 140                 


Phe Val Leu Phe Leu Phe Leu Gly Ile Leu Thr Met Leu Arg Pro Asn 
145                 150                 155                 160 


Met Tyr Phe Met Ala Pro Leu Gln Glu Lys Val Val Phe Gly Met Phe 
                165                 170                 175     


Phe Leu Gly Ala Val Leu Cys Leu Ser Phe Ser Trp Leu Phe His Thr 
            180                 185                 190         


Val Tyr Cys His Ser Glu Lys Val Ser Arg Thr Phe Ser Lys Leu Asp 
        195                 200                 205             


Tyr Ser Gly Ile Ala Leu Leu Ile Met Gly Ser Phe Val Pro Trp Leu 
    210                 215                 220                 


Tyr Tyr Ser Phe Tyr Cys Ser Pro Gln Pro Arg Leu Ile Tyr Leu Ser 
225                 230                 235                 240 


Ile Val Cys Val Leu Gly Ile Ser Ala Ile Ile Val Ala Gln Trp Asp 
                245                 250                 255     


Arg Phe Ala Thr Pro Lys His Arg Gln Thr Arg Ala Gly Val Phe Leu 
            260                 265                 270         


Gly Leu Gly Leu Ser Gly Val Val Pro Thr Met His Phe Thr Ile Ala 
        275                 280                 285             


Glu Gly Phe Val Lys Ala Thr Thr Val Gly Gln Met Gly Trp Phe Phe 
    290                 295                 300                 


Leu Met Ala Val Met Tyr Ile Thr Gly Ala Gly Leu Tyr Ala Ala Arg 
305                 310                 315                 320 


Ile Pro Glu Arg Phe Phe Pro Gly Lys Phe Asp Ile Trp Phe Gln Ser 
                325                 330                 335     


His Gln Ile Phe His Val Leu Val Val Ala Ala Ala Phe Val His Phe 
            340                 345                 350         


Tyr Gly Val Ser Asn Leu Gln Glu Phe Arg Tyr Gly Leu Glu Gly Gly 
        355                 360                 365             


Cys Thr Asp Asp Thr Leu Leu 
    370                 375 


<210>  1347
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  1347

Met Ser Ser Lys Tyr Pro Arg Ser Val Arg Arg Cys Leu Pro Leu Trp 
1               5                   10                  15      


Ala Leu Thr Leu Glu Ala Ala Leu Ile Leu Leu Phe Tyr Phe Phe Thr 
            20                  25                  30          


His Tyr Asp Ala Ser Leu Glu Asp Gln Lys Gly Leu Val Ala Ser Tyr 
        35                  40                  45              


Gln Val Gly Gln Asp Leu Thr Val Met Ala Ala Ile Gly Leu Gly Phe 
    50                  55                  60                  


Leu Thr Ser Ser Phe Arg Arg His Ser Trp Ser Ser Val Ala Phe Asn 
65                  70                  75                  80  


Leu Phe Met Leu Ala Leu Gly Val Gln Trp Ala Ile Leu Leu Asp Gly 
                85                  90                  95      


Phe Leu Ser Gln Phe Pro Ser Gly Lys Val Val Ile Thr Leu Phe Ser 
            100                 105                 110         


Ile Arg Leu Ala Thr Met Ser Ala Leu Ser Val Leu Ile Ser Val Asp 
        115                 120                 125             


Ala Val Leu Gly Lys Val Asn Leu Ala Gln Leu Val Val Met Val Leu 
    130                 135                 140                 


Val Glu Val Thr Ala Leu Gly Asn Leu Arg Met Val Ile Ser Asn Ile 
145                 150                 155                 160 


Phe Asn Thr Asp Tyr His Met Asn Met Met His Ile Tyr Val Phe Ala 
                165                 170                 175     


Ala Tyr Phe Gly Leu Ser Val Ala Trp Cys Leu Pro Lys Pro Leu Pro 
            180                 185                 190         


Glu Gly Thr Glu Asp Lys Asp Gln Thr Ala Thr Ile Pro Ser Leu Ser 
        195                 200                 205             


Ala Met Leu Gly Ala Leu Phe Leu Trp Met Phe Trp Pro Ser Phe Asn 
    210                 215                 220                 


Ser Ala Leu Leu Arg Ser Pro Ile Glu Arg Lys Asn Ala Val Phe Asn 
225                 230                 235                 240 


Thr Tyr Tyr Ala Val Ala Val Ser Val Val Thr Ala Ile Ser Gly Ser 
                245                 250                 255     


Ser Leu Ala His Pro Gln Gly Lys Ile Ser Lys Thr Tyr Val His Ser 
            260                 265                 270         


Ala Val Leu Ala Gly Gly Val Ala Val Gly Thr Ser Cys His Leu Ile 
        275                 280                 285             


Pro Ser Pro Trp Leu Ala Met Val Leu Gly Leu Val Ala Gly Leu Ile 
    290                 295                 300                 


Ser Val Gly Gly Ala Lys Tyr Leu Pro Phe Pro His Leu Ala Val Gly 
305                 310                 315                 320 


Phe 
    


<210>  1348
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  1348

Met Ile Arg Ala Ala Pro Pro Pro Leu Phe Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Val Ser Trp Ala Ser Arg Gly Glu Ala Ala Pro Asp Gln 
            20                  25                  30          


Asp Glu Ile Gln Arg Leu Pro Gly Leu Ala Lys Gln Pro Ser Phe Arg 
        35                  40                  45              


Gln Tyr Ser Gly Tyr Leu Lys Gly Ser Gly Ser Lys His Leu His Tyr 
    50                  55                  60                  


Trp Phe Val Glu Ser Gln Lys Asp Pro Glu Asn Ser Pro Val Val Leu 
65                  70                  75                  80  


Trp Leu Asn Gly Gly Pro Gly Cys Ser Ser Leu Asp Gly Leu Leu Thr 
                85                  90                  95      


Glu His Gly Pro Phe Leu Val Gln Pro Asp Gly Val Thr Leu Glu Tyr 
            100                 105                 110         


Asn Pro Tyr Ser Trp Asn Leu Ile Ala Asn Val Leu Tyr Leu Glu Ser 
        115                 120                 125             


Pro Ala Gly Val Gly Phe Ser Tyr Ser Asp Asp Lys Phe Tyr Ala Thr 
    130                 135                 140                 


Asn Asp Thr Glu Val Ala Gln Ser Asn Phe Glu Ala Leu Gln Asp Phe 
145                 150                 155                 160 


Phe Arg Leu Phe Pro Glu Tyr Lys Asn Asn Lys Leu Phe Leu Thr Gly 
                165                 170                 175     


Glu Ser Tyr Ala Gly Ile Tyr Ile Pro Thr Leu Ala Val Leu Val Met 
            180                 185                 190         


Gln Asp Pro Ser Met Asn Leu Gln Gly Leu Ala Val Gly Asn Gly Leu 
        195                 200                 205             


Ser Ser Tyr Glu Gln Asn Asp Asn Ser Leu Val Tyr Phe Ala Tyr Tyr 
    210                 215                 220                 


His Gly Leu Leu Gly Asn Arg Leu Trp Ser Ser Leu Gln Thr His Cys 
225                 230                 235                 240 


Cys Ser Gln Asn Lys Cys Asn Phe Tyr Asp Asn Lys Asp Leu Glu Cys 
                245                 250                 255     


Val Thr Asn Leu Gln Glu Val Ala Arg Ile Val Gly Asn Ser Gly Leu 
            260                 265                 270         


Asn Ile Tyr Asn Leu Tyr Ala Pro Cys Ala Gly Gly Val Pro Ser His 
        275                 280                 285             


Phe Arg Tyr Glu Lys Asp Thr Val Val Val Gln Asp Leu Gly Asn Ile 
    290                 295                 300                 


Phe Thr Arg Leu Pro Leu Lys Arg Met Trp His Gln Ala Leu Leu Arg 
305                 310                 315                 320 


Ser Gly Asp Lys Val Arg Met Asp Pro Pro Cys Thr Asn Thr Thr Ala 
                325                 330                 335     


Ala Ser Thr Tyr Leu Asn Asn Pro Tyr Val Arg Lys Ala Leu Asn Ile 
            340                 345                 350         


Pro Glu Gln Leu Pro Gln Trp Asp Met Cys Asn Phe Leu Val Asn Leu 
        355                 360                 365             


Gln Tyr Arg Arg Leu Tyr Arg Ser Met Asn Ser Gln Tyr Leu Lys Leu 
    370                 375                 380                 


Leu Ser Ser Gln Lys Tyr Gln Ile Leu Leu Tyr Asn Gly Asp Val Asp 
385                 390                 395                 400 


Met Ala Cys Asn Phe Met Gly Asp Glu Trp Phe Val Asp Ser Leu Asn 
                405                 410                 415     


Gln Lys Met Glu Val Gln Arg Arg Pro Trp Leu Val Lys Tyr Gly Asp 
            420                 425                 430         


Ser Gly Glu Gln Ile Ala Gly Phe Val Lys Glu Phe Ser His Ile Ala 
        435                 440                 445             


Phe Leu Thr Ile Lys Gly Ala Gly His Met Val Pro Thr Asp Lys Pro 
    450                 455                 460                 


Leu Ala Ala Phe Thr Met Phe Ser Arg Phe Leu Asn Lys Gln Pro Tyr 
465                 470                 475                 480 


<210>  1349
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  1349

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
            20                  25                  30          


Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
        35                  40                  45              


Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
    50                  55                  60                  


Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
65                  70                  75                  80  


Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                85                  90                  95      


His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
            100                 105                 110         


Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
        115                 120                 125             


Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
    130                 135                 140                 


Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
145                 150                 155                 160 


Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                165                 170                 175     


Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
            180                 185                 190         


Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
        195                 200                 205             


Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
    210                 215                 220                 


Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val 
225                 230                 235                 240 


Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                245                 250                 255     


Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
            260                 265                 270         


Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
        275                 280                 285             


Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
    290                 295                 300                 


Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
305                 310                 315                 320 


Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                325                 330                 335     


Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
            340                 345                 350         


Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
        355                 360                 365             


Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
    370                 375                 380                 


Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
385                 390                 395                 400 


Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                405                 410                 415     


Gln Lys 
        


<210>  1350
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  1350

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
            20                  25                  30          


Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
        35                  40                  45              


Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
    50                  55                  60                  


Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
65                  70                  75                  80  


Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                85                  90                  95      


His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
            100                 105                 110         


Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
        115                 120                 125             


Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
    130                 135                 140                 


Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
145                 150                 155                 160 


Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                165                 170                 175     


Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
            180                 185                 190         


Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
        195                 200                 205             


Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
    210                 215                 220                 


Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val 
225                 230                 235                 240 


Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                245                 250                 255     


Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
            260                 265                 270         


Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
        275                 280                 285             


Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
    290                 295                 300                 


Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
305                 310                 315                 320 


Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                325                 330                 335     


Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
            340                 345                 350         


Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
        355                 360                 365             


Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
    370                 375                 380                 


Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
385                 390                 395                 400 


Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                405                 410                 415     


Gln Lys 
        


<210>  1351
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  1351

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
            20                  25                  30          


Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
        35                  40                  45              


Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
    50                  55                  60                  


Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
65                  70                  75                  80  


Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                85                  90                  95      


His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
            100                 105                 110         


Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
        115                 120                 125             


Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
    130                 135                 140                 


Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
145                 150                 155                 160 


Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                165                 170                 175     


Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
            180                 185                 190         


Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
        195                 200                 205             


Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
    210                 215                 220                 


Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val 
225                 230                 235                 240 


Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                245                 250                 255     


Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
            260                 265                 270         


Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
        275                 280                 285             


Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
    290                 295                 300                 


Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
305                 310                 315                 320 


Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                325                 330                 335     


Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
            340                 345                 350         


Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
        355                 360                 365             


Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
    370                 375                 380                 


Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
385                 390                 395                 400 


Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                405                 410                 415     


Gln Lys 
        


<210>  1352
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  1352

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
            20                  25                  30          


Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
        35                  40                  45              


Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
    50                  55                  60                  


Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
65                  70                  75                  80  


Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                85                  90                  95      


His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
            100                 105                 110         


Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
        115                 120                 125             


Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
    130                 135                 140                 


Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
145                 150                 155                 160 


Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                165                 170                 175     


Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
            180                 185                 190         


Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
        195                 200                 205             


Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
    210                 215                 220                 


Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val 
225                 230                 235                 240 


Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                245                 250                 255     


Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
            260                 265                 270         


Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
        275                 280                 285             


Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
    290                 295                 300                 


Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
305                 310                 315                 320 


Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                325                 330                 335     


Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
            340                 345                 350         


Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
        355                 360                 365             


Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
    370                 375                 380                 


Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
385                 390                 395                 400 


Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                405                 410                 415     


Gln Lys 
        


<210>  1353
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  1353

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
            20                  25                  30          


Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
        35                  40                  45              


Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
    50                  55                  60                  


Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
65                  70                  75                  80  


Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                85                  90                  95      


His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
            100                 105                 110         


Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
        115                 120                 125             


Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
    130                 135                 140                 


Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
145                 150                 155                 160 


Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                165                 170                 175     


Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
            180                 185                 190         


Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
        195                 200                 205             


Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
    210                 215                 220                 


Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val 
225                 230                 235                 240 


Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                245                 250                 255     


Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
            260                 265                 270         


Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
        275                 280                 285             


Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
    290                 295                 300                 


Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
305                 310                 315                 320 


Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                325                 330                 335     


Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
            340                 345                 350         


Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
        355                 360                 365             


Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
    370                 375                 380                 


Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
385                 390                 395                 400 


Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                405                 410                 415     


Gln Lys 
        


<210>  1354
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  1354

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
            20                  25                  30          


Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
        35                  40                  45              


Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
    50                  55                  60                  


Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
65                  70                  75                  80  


Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                85                  90                  95      


His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
            100                 105                 110         


Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
        115                 120                 125             


Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
    130                 135                 140                 


Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
145                 150                 155                 160 


Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                165                 170                 175     


Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
            180                 185                 190         


Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
        195                 200                 205             


Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
    210                 215                 220                 


Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val 
225                 230                 235                 240 


Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                245                 250                 255     


Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
            260                 265                 270         


Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
        275                 280                 285             


Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
    290                 295                 300                 


Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
305                 310                 315                 320 


Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                325                 330                 335     


Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
            340                 345                 350         


Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
        355                 360                 365             


Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
    370                 375                 380                 


Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
385                 390                 395                 400 


Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                405                 410                 415     


Gln Lys 
        


<210>  1355
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  1355

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
            20                  25                  30          


Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
        35                  40                  45              


Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
    50                  55                  60                  


Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
65                  70                  75                  80  


Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                85                  90                  95      


His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
            100                 105                 110         


Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
        115                 120                 125             


Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
    130                 135                 140                 


Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
145                 150                 155                 160 


Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                165                 170                 175     


Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
            180                 185                 190         


Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
        195                 200                 205             


Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
    210                 215                 220                 


Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val 
225                 230                 235                 240 


Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                245                 250                 255     


Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
            260                 265                 270         


Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
        275                 280                 285             


Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
    290                 295                 300                 


Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
305                 310                 315                 320 


Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                325                 330                 335     


Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
            340                 345                 350         


Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
        355                 360                 365             


Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
    370                 375                 380                 


Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
385                 390                 395                 400 


Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                405                 410                 415     


Gln Lys 
        


<210>  1356
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  1356

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
            20                  25                  30          


Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
        35                  40                  45              


Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
    50                  55                  60                  


Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
65                  70                  75                  80  


Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                85                  90                  95      


His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
            100                 105                 110         


Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
        115                 120                 125             


Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
    130                 135                 140                 


Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
145                 150                 155                 160 


Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                165                 170                 175     


Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
            180                 185                 190         


Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
        195                 200                 205             


Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
    210                 215                 220                 


Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val 
225                 230                 235                 240 


Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                245                 250                 255     


Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
            260                 265                 270         


Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
        275                 280                 285             


Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
    290                 295                 300                 


Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
305                 310                 315                 320 


Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                325                 330                 335     


Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
            340                 345                 350         


Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
        355                 360                 365             


Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
    370                 375                 380                 


Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
385                 390                 395                 400 


Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                405                 410                 415     


Gln Lys 
        


<210>  1357
<211>  553
<212>  PRT
<213>  Homo sapiens

<400>  1357

Met Ala Lys Asn Arg Arg Asp Arg Asn Ser Trp Gly Gly Phe Ser Glu 
1               5                   10                  15      


Lys Thr Tyr Glu Trp Ser Ser Glu Glu Glu Glu Pro Val Lys Lys Ala 
            20                  25                  30          


Gly Pro Val Gln Val Leu Ile Val Lys Asp Asp His Ser Phe Glu Leu 
        35                  40                  45              


Asp Glu Thr Ala Leu Asn Arg Ile Leu Leu Ser Glu Ala Val Arg Asp 
    50                  55                  60                  


Lys Glu Val Val Ala Val Ser Val Ala Gly Ala Phe Arg Lys Gly Lys 
65                  70                  75                  80  


Ser Phe Leu Met Asp Phe Met Leu Arg Tyr Met Tyr Asn Gln Glu Ser 
                85                  90                  95      


Val Asp Trp Val Gly Asp Tyr Asn Glu Pro Leu Thr Gly Phe Ser Trp 
            100                 105                 110         


Arg Gly Gly Ser Glu Arg Glu Thr Thr Gly Ile Gln Ile Trp Ser Glu 
        115                 120                 125             


Ile Phe Leu Ile Asn Lys Pro Asp Gly Lys Lys Val Ala Val Leu Leu 
    130                 135                 140                 


Met Asp Thr Gln Gly Thr Phe Asp Ser Gln Ser Thr Leu Arg Asp Ser 
145                 150                 155                 160 


Ala Thr Val Phe Ala Leu Ser Thr Met Ile Ser Ser Ile Gln Val Tyr 
                165                 170                 175     


Asn Leu Ser Gln Asn Val Gln Glu Asp Asp Leu Gln His Leu Gln Leu 
            180                 185                 190         


Phe Thr Glu Tyr Gly Arg Leu Ala Met Glu Glu Thr Phe Leu Lys Pro 
        195                 200                 205             


Phe Gln Ser Leu Ile Phe Leu Val Arg Asp Trp Ser Phe Pro Tyr Glu 
    210                 215                 220                 


Phe Ser Tyr Gly Ala Asp Gly Gly Ala Lys Phe Leu Glu Lys Arg Leu 
225                 230                 235                 240 


Lys Val Ser Gly Asn Gln His Glu Glu Leu Gln Asn Val Arg Lys His 
                245                 250                 255     


Ile His Ser Cys Phe Thr Asn Ile Ser Cys Phe Leu Leu Pro His Pro 
            260                 265                 270         


Gly Leu Lys Val Ala Thr Asn Pro Asn Phe Asp Gly Lys Leu Lys Glu 
        275                 280                 285             


Ile Asp Asp Glu Phe Ile Lys Asn Leu Lys Ile Leu Ile Pro Trp Leu 
    290                 295                 300                 


Leu Ser Pro Glu Ser Leu Asp Ile Lys Glu Ile Asn Gly Asn Lys Ile 
305                 310                 315                 320 


Thr Cys Arg Gly Leu Val Glu Tyr Phe Lys Ala Tyr Ile Lys Ile Tyr 
                325                 330                 335     


Gln Gly Glu Glu Leu Pro His Pro Lys Ser Met Leu Gln Ala Thr Ala 
            340                 345                 350         


Glu Ala Asn Asn Leu Ala Ala Val Ala Thr Ala Lys Asp Thr Tyr Asn 
        355                 360                 365             


Lys Lys Met Glu Glu Ile Cys Gly Gly Asp Lys Pro Phe Leu Ala Pro 
    370                 375                 380                 


Asn Asp Leu Gln Thr Lys His Leu Gln Leu Lys Glu Glu Ser Val Lys 
385                 390                 395                 400 


Leu Phe Arg Gly Val Lys Lys Met Gly Gly Glu Glu Phe Ser Arg Arg 
                405                 410                 415     


Tyr Leu Gln Gln Leu Glu Ser Glu Ile Asp Glu Leu Tyr Ile Gln Tyr 
            420                 425                 430         


Ile Lys His Asn Asp Ser Lys Asn Ile Phe His Ala Ala Arg Thr Pro 
        435                 440                 445             


Ala Thr Leu Phe Val Val Ile Phe Ile Thr Tyr Val Ile Ala Gly Val 
    450                 455                 460                 


Thr Gly Phe Ile Gly Leu Asp Ile Ile Ala Ser Leu Cys Asn Met Ile 
465                 470                 475                 480 


Met Gly Leu Thr Leu Ile Thr Leu Cys Thr Trp Ala Tyr Ile Arg Tyr 
                485                 490                 495     


Ser Gly Glu Tyr Arg Glu Leu Gly Ala Val Ile Asp Gln Val Ala Ala 
            500                 505                 510         


Ala Leu Trp Asp Gln Ala Leu Tyr Lys Leu Tyr Ser Ala Ala Ala Thr 
        515                 520                 525             


His Arg His Leu Tyr His Gln Ala Phe Pro Thr Pro Lys Ser Glu Ser 
    530                 535                 540                 


Thr Glu Gln Ser Glu Lys Lys Lys Met 
545                 550             


<210>  1358
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  1358

Met Glu Ile Pro Met Gly Thr Gln Gly Cys Phe Ser Lys Ser Leu Leu 
1               5                   10                  15      


Leu Ser Ala Ser Ile Leu Val Leu Trp Met Leu Gln Gly Ser Gln Ala 
            20                  25                  30          


Ala Leu Tyr Ile Gln Lys Ile Pro Glu Gln Pro Gln Lys Asn Gln Asp 
        35                  40                  45              


Leu Leu Leu Ser Val Gln Gly Val Pro Asp Thr Phe Gln Asp Phe Asn 
    50                  55                  60                  


Trp Tyr Leu Gly Glu Glu Thr Tyr Gly Gly Thr Arg Leu Phe Thr Tyr 
65                  70                  75                  80  


Ile Pro Gly Ile Gln Arg Pro Gln Arg Asp Gly Ser Ala Met Gly Gln 
                85                  90                  95      


Arg Asp Ile Val Gly Phe Pro Asn Gly Ser Met Leu Leu Arg Arg Ala 
            100                 105                 110         


Gln Pro Thr Asp Ser Gly Thr Tyr Gln Val Ala Ile Thr Ile Asn Ser 
        115                 120                 125             


Glu Trp Thr Met Lys Ala Lys Thr Glu Val Gln Val Ala Glu Lys Asn 
    130                 135                 140                 


Lys Glu Leu Pro Ser Thr His Leu Pro Thr Asn Ala Gly Ile Leu Ala 
145                 150                 155                 160 


Ala Thr Ile Ile Gly Ser Leu Ala Ala Gly Ala Leu Leu Ile Ser Cys 
                165                 170                 175     


Ile Ala Tyr Leu Leu Val Thr Arg Asn Trp Arg Gly Gln Ser His Arg 
            180                 185                 190         


Leu Pro Ala Pro Arg Gly Gln Gly Ser Leu Ser Ile Leu Cys Ser Ala 
        195                 200                 205             


Val Ser Pro Val Pro Ser Val Thr Pro Ser Thr Trp Met Ala Thr Thr 
    210                 215                 220                 


Glu Lys Pro Glu Leu Gly Pro Ala His Asp Ala Gly Asp Asn Asn Ile 
225                 230                 235                 240 


Tyr Glu Val Met Pro Ser Pro Val Leu Leu Val Ser Pro Ile Ser Asp 
                245                 250                 255     


Thr Arg Ser Ile Asn Pro Ala Arg Pro Leu Pro Thr Pro Pro His Leu 
            260                 265                 270         


Gln Ala Glu Pro Glu Asn His Gln Tyr Gln Asp Leu Leu Asn Pro Asp 
        275                 280                 285             


Pro Ala Pro Tyr Cys Gln Leu Val Pro Thr Ser 
    290                 295                 


<210>  1359
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  1359

Met Thr Leu Arg Pro Gly Thr Met Arg Leu Ala Cys Met Phe Ser Ser 
1               5                   10                  15      


Ile Leu Leu Phe Gly Ala Ala Gly Leu Leu Leu Phe Ile Ser Leu Gln 
            20                  25                  30          


Asp Pro Thr Glu Leu Ala Pro Gln Gln Val Pro Gly Ile Lys Phe Asn 
        35                  40                  45              


Ile Arg Pro Arg Gln Pro His His Asp Leu Pro Pro Gly Gly Ser Gln 
    50                  55                  60                  


Asp Gly Asp Leu Lys Glu Pro Thr Glu Arg Val Thr Arg Asp Leu Ser 
65                  70                  75                  80  


Ser Gly Ala Pro Arg Gly Arg Asn Leu Pro Ala Pro Asp Gln Pro Gln 
                85                  90                  95      


Pro Pro Leu Gln Arg Gly Thr Arg Leu Arg Leu Arg Gln Arg Arg Arg 
            100                 105                 110         


Arg Leu Leu Ile Lys Lys Met Pro Ala Ala Ala Thr Ile Pro Ala Asn 
        115                 120                 125             


Ser Ser Asp Ala Pro Phe Ile Arg Pro Gly Pro Gly Thr Leu Asp Gly 
    130                 135                 140                 


Arg Trp Val Ser Leu His Arg Ser Gln Gln Glu Arg Lys Arg Val Met 
145                 150                 155                 160 


Gln Glu Ala Cys Ala Lys Tyr Arg Ala Ser Ser Ser Arg Arg Ala Val 
                165                 170                 175     


Thr Pro Arg His Val Ser Arg Ile Phe Val Glu Asp Arg His Arg Val 
            180                 185                 190         


Leu Tyr Cys Glu Val Pro Lys Ala Gly Cys Ser Asn Trp Lys Arg Val 
        195                 200                 205             


Leu Met Val Leu Ala Gly Leu Ala Ser Ser Thr Ala Asp Ile Gln His 
    210                 215                 220                 


Asn Thr Val His Tyr Gly Ser Ala Leu Lys Arg Leu Asp Thr Phe Asp 
225                 230                 235                 240 


Arg Gln Gly Ile Leu His Arg Leu Ser Thr Tyr Thr Lys Met Leu Phe 
                245                 250                 255     


Val Arg Glu Pro Phe Glu Arg Leu Val Ser Ala Phe Arg Asp Lys Phe 
            260                 265                 270         


Glu His Pro Asn Ser Tyr Tyr His Pro Val Phe Gly Lys Ala Ile Leu 
        275                 280                 285             


Ala Arg Tyr Arg Ala Asn Ala Ser Arg Glu Ala Leu Arg Thr Gly Ser 
    290                 295                 300                 


Gly Val Arg Phe Pro Glu Phe Val Gln Tyr Leu Leu Asp Val His Arg 
305                 310                 315                 320 


Pro Val Gly Met Asp Ile His Trp Asp His Val Ser Arg Leu Cys Ser 
                325                 330                 335     


Pro Cys Leu Ile Asp Tyr Asp Phe Val Gly Lys Phe Glu Ser Met Glu 
            340                 345                 350         


Asp Asp Ala Asn Phe Phe Leu Ser Leu Ile Arg Ala Pro Arg Asn Leu 
        355                 360                 365             


Thr Phe Pro Arg Phe Lys Asp Arg His Ser Gln Glu Ala Arg Thr Thr 
    370                 375                 380                 


Ala Arg Ile Ala His Gln Tyr Phe Ala Gln Leu Ser Ala Leu Gln Arg 
385                 390                 395                 400 


Gln Arg Thr Tyr Asp Phe Tyr Tyr Met Asp Tyr Leu Met Phe Asn Tyr 
                405                 410                 415     


Ser Lys Pro Phe Ala Asp Leu Tyr 
            420                 


<210>  1360
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  1360

Met Thr Leu Arg Pro Gly Thr Met Arg Leu Ala Cys Met Phe Ser Ser 
1               5                   10                  15      


Ile Leu Leu Phe Gly Ala Ala Gly Leu Leu Leu Phe Ile Ser Leu Gln 
            20                  25                  30          


Asp Pro Thr Glu Leu Ala Pro Gln Gln Val Pro Gly Ile Lys Phe Asn 
        35                  40                  45              


Ile Arg Pro Arg Gln Pro His His Asp Leu Pro Pro Gly Gly Ser Gln 
    50                  55                  60                  


Asp Gly Asp Leu Lys Glu Pro Thr Glu Arg Val Thr Arg Asp Leu Ser 
65                  70                  75                  80  


Ser Gly Ala Pro Arg Gly Arg Asn Leu Pro Ala Pro Asp Gln Pro Gln 
                85                  90                  95      


Pro Pro Leu Gln Arg Gly Thr Arg Leu Arg Leu Arg Gln Arg Arg Arg 
            100                 105                 110         


Arg Leu Leu Ile Lys Lys Met Pro Ala Ala Ala Thr Ile Pro Ala Asn 
        115                 120                 125             


Ser Ser Asp Ala Pro Phe Ile Arg Pro Gly Pro Gly Thr Leu Asp Gly 
    130                 135                 140                 


Arg Trp Val Ser Leu His Arg Ser Gln Gln Glu Arg Lys Arg Val Met 
145                 150                 155                 160 


Gln Glu Ala Cys Ala Lys Tyr Arg Ala Ser Ser Ser Arg Arg Ala Val 
                165                 170                 175     


Thr Pro Arg His Val Ser Arg Ile Phe Val Glu Asp Arg His Arg Val 
            180                 185                 190         


Leu Tyr Cys Glu Val Pro Lys Ala Gly Cys Ser Asn Trp Lys Arg Val 
        195                 200                 205             


Leu Met Val Leu Ala Gly Leu Ala Ser Ser Thr Ala Asp Ile Gln His 
    210                 215                 220                 


Asn Thr Val His Tyr Gly Ser Ala Leu Lys Arg Leu Asp Thr Phe Asp 
225                 230                 235                 240 


Arg Gln Gly Ile Leu His Arg Leu Ser Thr Tyr Thr Lys Met Leu Phe 
                245                 250                 255     


Val Arg Glu Pro Phe Glu Arg Leu Val Ser Ala Phe Arg Asp Lys Phe 
            260                 265                 270         


Glu His Pro Asn Ser Tyr Tyr His Pro Val Phe Gly Lys Ala Ile Leu 
        275                 280                 285             


Ala Arg Tyr Arg Ala Asn Ala Ser Arg Glu Ala Leu Arg Thr Gly Ser 
    290                 295                 300                 


Gly Val Arg Phe Pro Glu Phe Val Gln Tyr Leu Leu Asp Val His Arg 
305                 310                 315                 320 


Pro Val Gly Met Asp Ile His Trp Asp His Val Ser Arg Leu Cys Ser 
                325                 330                 335     


Pro Cys Leu Ile Asp Tyr Asp Phe Val Gly Lys Phe Glu Ser Met Glu 
            340                 345                 350         


Asp Asp Ala Asn Phe Phe Leu Ser Leu Ile Arg Ala Pro Arg Asn Leu 
        355                 360                 365             


Thr Phe Pro Arg Phe Lys Asp Arg His Ser Gln Glu Ala Arg Thr Thr 
    370                 375                 380                 


Ala Arg Ile Ala His Gln Tyr Phe Ala Gln Leu Ser Ala Leu Gln Arg 
385                 390                 395                 400 


Gln Arg Thr Tyr Asp Phe Tyr Tyr Met Asp Tyr Leu Met Phe Asn Tyr 
                405                 410                 415     


Ser Lys Pro Phe Ala Asp Leu Tyr 
            420                 


<210>  1361
<211>  816
<212>  PRT
<213>  Homo sapiens

<400>  1361

Met Ala Met Trp Gln Gly Ala Met Asp Asn Arg Gly Phe Gln Gln Gly 
1               5                   10                  15      


Ser Phe Ser Ser Phe Gln Asn Ser Ser Ser Asp Glu Asp Leu Met Asp 
            20                  25                  30          


Ile Pro Ala Thr Ala Met Asp Phe Ser Met Arg Asp Asp Val Pro Pro 
        35                  40                  45              


Leu Asp Arg Glu Val Gly Glu Asp Lys Ser Tyr Asn Gly Gly Gly Ile 
    50                  55                  60                  


Gly Ser Ser Asn Arg Ile Met Asp Phe Leu Glu Glu Pro Ile Pro Gly 
65                  70                  75                  80  


Val Gly Thr Tyr Asp Asp Phe Asn Thr Ile Asp Trp Val Arg Glu Lys 
                85                  90                  95      


Ser Arg Asp Arg Asp Arg His Arg Glu Ile Thr Asn Lys Ser Lys Glu 
            100                 105                 110         


Ser Thr Trp Ala Leu Ile His Ser Val Ser Asp Ala Phe Ser Gly Trp 
        115                 120                 125             


Leu Leu Met Leu Leu Ile Gly Leu Leu Ser Gly Ser Leu Ala Gly Leu 
    130                 135                 140                 


Ile Asp Ile Ser Ala His Trp Met Thr Asp Leu Lys Glu Gly Ile Cys 
145                 150                 155                 160 


Thr Gly Gly Phe Trp Phe Asn His Glu His Cys Cys Trp Asn Ser Glu 
                165                 170                 175     


His Val Thr Phe Glu Glu Arg Asp Lys Cys Pro Glu Trp Asn Ser Trp 
            180                 185                 190         


Ser Gln Leu Ile Ile Ser Thr Asp Glu Gly Ala Phe Ala Tyr Ile Val 
        195                 200                 205             


Asn Tyr Phe Met Tyr Val Leu Trp Ala Leu Leu Phe Ala Phe Leu Ala 
    210                 215                 220                 


Val Ser Leu Val Lys Val Phe Ala Pro Tyr Ala Cys Gly Ser Gly Ile 
225                 230                 235                 240 


Pro Glu Ile Lys Thr Ile Leu Ser Gly Phe Ile Ile Arg Gly Tyr Leu 
                245                 250                 255     


Gly Lys Trp Thr Leu Val Ile Lys Thr Ile Thr Leu Val Leu Ala Val 
            260                 265                 270         


Ser Ser Gly Leu Ser Leu Gly Lys Glu Gly Pro Leu Val His Val Ala 
        275                 280                 285             


Cys Cys Cys Gly Asn Ile Leu Cys His Cys Phe Asn Lys Tyr Arg Lys 
    290                 295                 300                 


Asn Glu Ala Lys Arg Arg Glu Val Leu Ser Ala Ala Ala Ala Ala Gly 
305                 310                 315                 320 


Val Ser Val Ala Phe Gly Ala Pro Ile Gly Gly Val Leu Phe Ser Leu 
                325                 330                 335     


Glu Glu Val Ser Tyr Tyr Phe Pro Leu Lys Thr Leu Trp Arg Ser Phe 
            340                 345                 350         


Phe Ala Ala Leu Val Ala Ala Phe Thr Leu Arg Ser Ile Asn Pro Phe 
        355                 360                 365             


Gly Asn Ser Arg Leu Val Leu Phe Tyr Val Glu Phe His Thr Pro Trp 
    370                 375                 380                 


His Leu Phe Glu Leu Val Pro Phe Ile Leu Leu Gly Ile Phe Gly Gly 
385                 390                 395                 400 


Leu Trp Gly Ala Leu Phe Ile Arg Thr Asn Ile Ala Trp Cys Arg Lys 
                405                 410                 415     


Arg Lys Thr Thr Gln Leu Gly Lys Tyr Pro Val Ile Glu Val Leu Val 
            420                 425                 430         


Val Thr Ala Ile Thr Ala Ile Leu Ala Phe Pro Asn Glu Tyr Thr Arg 
        435                 440                 445             


Met Ser Thr Ser Glu Leu Ile Ser Glu Leu Phe Asn Asp Cys Gly Leu 
    450                 455                 460                 


Leu Asp Ser Ser Lys Leu Cys Asp Tyr Glu Asn Arg Phe Asn Thr Ser 
465                 470                 475                 480 


Lys Gly Gly Glu Leu Pro Asp Arg Pro Ala Gly Val Gly Val Tyr Ser 
                485                 490                 495     


Ala Met Trp Gln Leu Ala Leu Thr Leu Ile Leu Lys Ile Val Ile Thr 
            500                 505                 510         


Ile Phe Thr Phe Gly Met Lys Ile Pro Ser Gly Leu Phe Ile Pro Ser 
        515                 520                 525             


Met Ala Val Gly Ala Ile Ala Gly Arg Leu Leu Gly Val Gly Met Glu 
    530                 535                 540                 


Gln Leu Ala Tyr Tyr His Gln Glu Trp Thr Val Phe Asn Ser Trp Cys 
545                 550                 555                 560 


Ser Gln Gly Ala Asp Cys Ile Thr Pro Gly Leu Tyr Ala Met Val Gly 
                565                 570                 575     


Ala Ala Ala Cys Leu Gly Gly Val Thr Arg Met Thr Val Ser Leu Val 
            580                 585                 590         


Val Ile Met Phe Glu Leu Thr Gly Gly Leu Glu Tyr Ile Val Pro Leu 
        595                 600                 605             


Met Ala Ala Ala Met Thr Ser Lys Trp Val Ala Asp Ala Leu Gly Arg 
    610                 615                 620                 


Glu Gly Ile Tyr Asp Ala His Ile Arg Leu Asn Gly Tyr Pro Phe Leu 
625                 630                 635                 640 


Glu Ala Lys Glu Glu Phe Ala His Lys Thr Leu Ala Met Asp Val Met 
                645                 650                 655     


Lys Pro Arg Arg Asn Asp Pro Leu Leu Thr Val Leu Thr Gln Asp Ser 
            660                 665                 670         


Met Thr Val Glu Asp Val Glu Thr Ile Ile Ser Glu Thr Thr Tyr Ser 
        675                 680                 685             


Gly Phe Pro Val Val Val Ser Arg Glu Ser Gln Arg Leu Val Gly Phe 
    690                 695                 700                 


Val Leu Arg Arg Asp Leu Ile Ile Ser Ile Glu Asn Ala Arg Lys Lys 
705                 710                 715                 720 


Gln Asp Gly Val Val Ser Thr Ser Ile Ile Tyr Phe Thr Glu His Ser 
                725                 730                 735     


Pro Pro Leu Pro Pro Tyr Thr Pro Pro Thr Leu Lys Leu Arg Asn Ile 
            740                 745                 750         


Leu Asp Leu Ser Pro Phe Thr Val Thr Asp Leu Thr Pro Met Glu Ile 
        755                 760                 765             


Val Val Asp Ile Phe Arg Lys Leu Gly Leu Arg Gln Cys Leu Val Thr 
    770                 775                 780                 


His Asn Gly Arg Leu Leu Gly Ile Ile Thr Lys Lys Asp Val Leu Lys 
785                 790                 795                 800 


His Ile Ala Gln Met Ala Asn Gln Asp Pro Asp Ser Ile Leu Phe Asn 
                805                 810                 815     


<210>  1362
<211>  816
<212>  PRT
<213>  Homo sapiens

<400>  1362

Met Ala Met Trp Gln Gly Ala Met Asp Asn Arg Gly Phe Gln Gln Gly 
1               5                   10                  15      


Ser Phe Ser Ser Phe Gln Asn Ser Ser Ser Asp Glu Asp Leu Met Asp 
            20                  25                  30          


Ile Pro Ala Thr Ala Met Asp Phe Ser Met Arg Asp Asp Val Pro Pro 
        35                  40                  45              


Leu Asp Arg Glu Val Gly Glu Asp Lys Ser Tyr Asn Gly Gly Gly Ile 
    50                  55                  60                  


Gly Ser Ser Asn Arg Ile Met Asp Phe Leu Glu Glu Pro Ile Pro Gly 
65                  70                  75                  80  


Val Gly Thr Tyr Asp Asp Phe Asn Thr Ile Asp Trp Val Arg Glu Lys 
                85                  90                  95      


Ser Arg Asp Arg Asp Arg His Arg Glu Ile Thr Asn Lys Ser Lys Glu 
            100                 105                 110         


Ser Thr Trp Ala Leu Ile His Ser Val Ser Asp Ala Phe Ser Gly Trp 
        115                 120                 125             


Leu Leu Met Leu Leu Ile Gly Leu Leu Ser Gly Ser Leu Ala Gly Leu 
    130                 135                 140                 


Ile Asp Ile Ser Ala His Trp Met Thr Asp Leu Lys Glu Gly Ile Cys 
145                 150                 155                 160 


Thr Gly Gly Phe Trp Phe Asn His Glu His Cys Cys Trp Asn Ser Glu 
                165                 170                 175     


His Val Thr Phe Glu Glu Arg Asp Lys Cys Pro Glu Trp Asn Ser Trp 
            180                 185                 190         


Ser Gln Leu Ile Ile Ser Thr Asp Glu Gly Ala Phe Ala Tyr Ile Val 
        195                 200                 205             


Asn Tyr Phe Met Tyr Val Leu Trp Ala Leu Leu Phe Ala Phe Leu Ala 
    210                 215                 220                 


Val Ser Leu Val Lys Val Phe Ala Pro Tyr Ala Cys Gly Ser Gly Ile 
225                 230                 235                 240 


Pro Glu Ile Lys Thr Ile Leu Ser Gly Phe Ile Ile Arg Gly Tyr Leu 
                245                 250                 255     


Gly Lys Trp Thr Leu Val Ile Lys Thr Ile Thr Leu Val Leu Ala Val 
            260                 265                 270         


Ser Ser Gly Leu Ser Leu Gly Lys Glu Gly Pro Leu Val His Val Ala 
        275                 280                 285             


Cys Cys Cys Gly Asn Ile Leu Cys His Cys Phe Asn Lys Tyr Arg Lys 
    290                 295                 300                 


Asn Glu Ala Lys Arg Arg Glu Val Leu Ser Ala Ala Ala Ala Ala Gly 
305                 310                 315                 320 


Val Ser Val Ala Phe Gly Ala Pro Ile Gly Gly Val Leu Phe Ser Leu 
                325                 330                 335     


Glu Glu Val Ser Tyr Tyr Phe Pro Leu Lys Thr Leu Trp Arg Ser Phe 
            340                 345                 350         


Phe Ala Ala Leu Val Ala Ala Phe Thr Leu Arg Ser Ile Asn Pro Phe 
        355                 360                 365             


Gly Asn Ser Arg Leu Val Leu Phe Tyr Val Glu Phe His Thr Pro Trp 
    370                 375                 380                 


His Leu Phe Glu Leu Val Pro Phe Ile Leu Leu Gly Ile Phe Gly Gly 
385                 390                 395                 400 


Leu Trp Gly Ala Leu Phe Ile Arg Thr Asn Ile Ala Trp Cys Arg Lys 
                405                 410                 415     


Arg Lys Thr Thr Gln Leu Gly Lys Tyr Pro Val Ile Glu Val Leu Val 
            420                 425                 430         


Val Thr Ala Ile Thr Ala Ile Leu Ala Phe Pro Asn Glu Tyr Thr Arg 
        435                 440                 445             


Met Ser Thr Ser Glu Leu Ile Ser Glu Leu Phe Asn Asp Cys Gly Leu 
    450                 455                 460                 


Leu Asp Ser Ser Lys Leu Cys Asp Tyr Glu Asn Arg Phe Asn Thr Ser 
465                 470                 475                 480 


Lys Gly Gly Glu Leu Pro Asp Arg Pro Ala Gly Val Gly Val Tyr Ser 
                485                 490                 495     


Ala Met Trp Gln Leu Ala Leu Thr Leu Ile Leu Lys Ile Val Ile Thr 
            500                 505                 510         


Ile Phe Thr Phe Gly Met Lys Ile Pro Ser Gly Leu Phe Ile Pro Ser 
        515                 520                 525             


Met Ala Val Gly Ala Ile Ala Gly Arg Leu Leu Gly Val Gly Met Glu 
    530                 535                 540                 


Gln Leu Ala Tyr Tyr His Gln Glu Trp Thr Val Phe Asn Ser Trp Cys 
545                 550                 555                 560 


Ser Gln Gly Ala Asp Cys Ile Thr Pro Gly Leu Tyr Ala Met Val Gly 
                565                 570                 575     


Ala Ala Ala Cys Leu Gly Gly Val Thr Arg Met Thr Val Ser Leu Val 
            580                 585                 590         


Val Ile Met Phe Glu Leu Thr Gly Gly Leu Glu Tyr Ile Val Pro Leu 
        595                 600                 605             


Met Ala Ala Ala Met Thr Ser Lys Trp Val Ala Asp Ala Leu Gly Arg 
    610                 615                 620                 


Glu Gly Ile Tyr Asp Ala His Ile Arg Leu Asn Gly Tyr Pro Phe Leu 
625                 630                 635                 640 


Glu Ala Lys Glu Glu Phe Ala His Lys Thr Leu Ala Met Asp Val Met 
                645                 650                 655     


Lys Pro Arg Arg Asn Asp Pro Leu Leu Thr Val Leu Thr Gln Asp Ser 
            660                 665                 670         


Met Thr Val Glu Asp Val Glu Thr Ile Ile Ser Glu Thr Thr Tyr Ser 
        675                 680                 685             


Gly Phe Pro Val Val Val Ser Arg Glu Ser Gln Arg Leu Val Gly Phe 
    690                 695                 700                 


Val Leu Arg Arg Asp Leu Ile Ile Ser Ile Glu Asn Ala Arg Lys Lys 
705                 710                 715                 720 


Gln Asp Gly Val Val Ser Thr Ser Ile Ile Tyr Phe Thr Glu His Ser 
                725                 730                 735     


Pro Pro Leu Pro Pro Tyr Thr Pro Pro Thr Leu Lys Leu Arg Asn Ile 
            740                 745                 750         


Leu Asp Leu Ser Pro Phe Thr Val Thr Asp Leu Thr Pro Met Glu Ile 
        755                 760                 765             


Val Val Asp Ile Phe Arg Lys Leu Gly Leu Arg Gln Cys Leu Val Thr 
    770                 775                 780                 


His Asn Gly Arg Leu Leu Gly Ile Ile Thr Lys Lys Asp Val Leu Lys 
785                 790                 795                 800 


His Ile Ala Gln Met Ala Asn Gln Asp Pro Asp Ser Ile Leu Phe Asn 
                805                 810                 815     


<210>  1363
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  1363

Met Asn Val Gly Val Ala His Ser Glu Val Asn Pro Asn Thr Arg Val 
1               5                   10                  15      


Met Asn Ser Arg Gly Met Trp Leu Thr Tyr Ala Leu Gly Val Gly Leu 
            20                  25                  30          


Leu His Ile Val Leu Leu Ser Ile Pro Phe Phe Ser Val Pro Val Ala 
        35                  40                  45              


Trp Thr Leu Thr Asn Ile Ile His Asn Leu Gly Met Tyr Val Phe Leu 
    50                  55                  60                  


His Ala Val Lys Gly Thr Pro Phe Glu Thr Pro Asp Gln Gly Lys Ala 
65                  70                  75                  80  


Arg Leu Leu Thr His Trp Glu Gln Leu Asp Tyr Gly Val Gln Phe Thr 
                85                  90                  95      


Ser Ser Arg Lys Phe Phe Thr Ile Ser Pro Ile Ile Leu Tyr Phe Leu 
            100                 105                 110         


Ala Ser Phe Tyr Thr Lys Tyr Asp Pro Thr His Phe Ile Leu Asn Thr 
        115                 120                 125             


Ala Ser Leu Leu Ser Val Leu Ile Pro Lys Met Pro Gln Leu His Gly 
    130                 135                 140                 


Val Arg Ile Phe Gly Ile Asn Lys Tyr 
145                 150             


<210>  1364
<211>  541
<212>  PRT
<213>  Homo sapiens

<400>  1364

Met Lys Ser Tyr Thr Pro Tyr Phe Ile Leu Leu Trp Ser Ala Val Gly 
1               5                   10                  15      


Ile Ala Lys Ala Ala Lys Ile Ile Ile Val Pro Pro Ile Met Phe Glu 
            20                  25                  30          


Ser His Met Tyr Ile Phe Lys Thr Leu Ala Ser Ala Leu His Glu Arg 
        35                  40                  45              


Gly His His Thr Val Phe Leu Leu Ser Glu Gly Arg Asp Ile Ala Pro 
    50                  55                  60                  


Ser Asn His Tyr Ser Leu Gln Arg Tyr Pro Gly Ile Phe Asn Ser Thr 
65                  70                  75                  80  


Thr Ser Asp Ala Phe Leu Gln Ser Lys Met Arg Asn Ile Phe Ser Gly 
                85                  90                  95      


Arg Leu Thr Ala Ile Glu Leu Phe Asp Ile Leu Asp His Tyr Thr Lys 
            100                 105                 110         


Asn Cys Asp Leu Met Val Gly Asn His Ala Leu Ile Gln Gly Leu Lys 
        115                 120                 125             


Lys Glu Lys Phe Asp Leu Leu Leu Val Asp Pro Asn Asp Met Cys Gly 
    130                 135                 140                 


Phe Val Ile Ala His Leu Leu Gly Val Lys Tyr Ala Val Phe Ser Thr 
145                 150                 155                 160 


Gly Leu Trp Tyr Pro Ala Glu Val Gly Ala Pro Ala Pro Leu Ala Tyr 
                165                 170                 175     


Val Pro Glu Phe Asn Ser Leu Leu Thr Asp Arg Met Asn Leu Leu Gln 
            180                 185                 190         


Arg Met Lys Asn Thr Gly Val Tyr Leu Ile Ser Arg Leu Gly Val Ser 
        195                 200                 205             


Phe Leu Val Leu Pro Lys Tyr Glu Arg Ile Met Gln Lys Tyr Asn Leu 
    210                 215                 220                 


Leu Pro Glu Lys Ser Met Tyr Asp Leu Val His Gly Ser Ser Leu Trp 
225                 230                 235                 240 


Met Leu Cys Thr Asp Val Ala Leu Glu Phe Pro Arg Pro Thr Leu Pro 
                245                 250                 255     


Asn Val Val Tyr Val Gly Gly Ile Leu Thr Lys Pro Ala Ser Pro Leu 
            260                 265                 270         


Pro Glu Asp Leu Gln Arg Trp Val Asn Gly Ala Asn Glu His Gly Phe 
        275                 280                 285             


Val Leu Val Ser Phe Gly Ala Gly Val Lys Tyr Leu Ser Glu Asp Ile 
    290                 295                 300                 


Ala Asn Lys Leu Ala Gly Ala Leu Gly Arg Leu Pro Gln Lys Val Ile 
305                 310                 315                 320 


Trp Arg Phe Ser Gly Pro Lys Pro Lys Asn Leu Gly Asn Asn Thr Lys 
                325                 330                 335     


Leu Ile Glu Trp Leu Pro Gln Asn Asp Leu Leu Gly His Ser Lys Ile 
            340                 345                 350         


Lys Ala Phe Leu Ser His Gly Gly Leu Asn Ser Ile Phe Glu Thr Met 
        355                 360                 365             


Tyr His Gly Val Pro Val Val Gly Ile Pro Leu Phe Gly Asp His Tyr 
    370                 375                 380                 


Asp Thr Met Thr Arg Val Gln Ala Lys Gly Met Gly Ile Leu Leu Glu 
385                 390                 395                 400 


Trp Lys Thr Val Thr Glu Lys Glu Leu Tyr Glu Ala Leu Val Lys Val 
                405                 410                 415     


Ile Asn Asn Pro Ser Tyr Arg Gln Arg Ala Gln Lys Leu Ser Glu Ile 
            420                 425                 430         


His Lys Asp Gln Pro Gly His Pro Val Asn Arg Thr Ile Tyr Trp Ile 
        435                 440                 445             


Asp Tyr Ile Ile Arg His Asn Gly Ala His His Leu Arg Ala Ala Val 
    450                 455                 460                 


His Gln Ile Ser Phe Cys Gln Tyr Phe Leu Leu Asp Ile Ala Phe Val 
465                 470                 475                 480 


Leu Leu Leu Gly Ala Ala Leu Leu Tyr Phe Leu Leu Ser Trp Val Thr 
                485                 490                 495     


Lys Phe Ile Tyr Arg Lys Ile Lys Ser Leu Trp Ser Arg Asn Lys His 
            500                 505                 510         


Ser Thr Val Asn Gly His Tyr His Asn Gly Ile Leu Asn Gly Lys Tyr 
        515                 520                 525             


Lys Arg Asn Gly His Ile Lys His Glu Lys Lys Val Lys 
    530                 535                 540     


<210>  1365
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  1365

Met Ile Glu Asp Ser Gly Lys Arg Gly Asn Thr Met Ala Glu Arg Arg 
1               5                   10                  15      


Gln Leu Phe Ala Glu Met Arg Ala Gln Asp Leu Asp Arg Ile Arg Leu 
            20                  25                  30          


Ser Thr Tyr Arg Thr Ala Cys Lys Leu Arg Phe Val Gln Lys Lys Cys 
        35                  40                  45              


Asn Leu His Leu Val Asp Ile Trp Asn Val Ile Glu Ala Leu Arg Glu 
    50                  55                  60                  


Asn Ala Leu Asn Asn Leu Asp Pro Asn Thr Glu Leu Asn Val Ser Arg 
65                  70                  75                  80  


Leu Glu Ala Val Leu Ser Thr Ile Phe Tyr Gln Leu Asn Lys Arg Met 
                85                  90                  95      


Pro Thr Thr His Gln Ile His Val Glu Gln Ser Ile Ser Leu Leu Leu 
            100                 105                 110         


Asn Phe Leu Leu Ala Ala Phe Asp Pro Glu Gly His Gly Lys Ile Ser 
        115                 120                 125             


Val Phe Ala Val Lys Met Ala Leu Ala Thr Leu Cys Gly Gly Lys Ile 
    130                 135                 140                 


Met Asp Lys Leu Arg Tyr Ile Phe Ser Met Ile Ser Asp Ser Ser Gly 
145                 150                 155                 160 


Val Met Val Tyr Gly Arg Tyr Asp Gln Phe Leu Arg Glu Val Leu Lys 
                165                 170                 175     


Leu Pro Thr Ala Val Phe Glu Gly Pro Ser Phe Gly Tyr Thr Glu Gln 
            180                 185                 190         


Ser Ala Arg Ser Cys Phe Ser Gln Gln Lys Lys Val Thr Leu Asn Gly 
        195                 200                 205             


Phe Leu Asp Thr Leu Met Ser Asp Pro Pro Pro Gln Cys Leu Val Trp 
    210                 215                 220                 


Leu Pro Leu Leu His Arg Leu Ala Asn Val Glu Asn Val Phe His Pro 
225                 230                 235                 240 


Val Glu Cys Ser Tyr Cys His Ser Glu Ser Met Met Gly Phe Arg Tyr 
                245                 250                 255     


Arg Cys Gln Gln Cys His Asn Tyr Gln Leu Cys Gln Asp Cys Phe Trp 
            260                 265                 270         


Arg Gly His Ala Gly Gly Ser His Ser Asn Gln His Gln Met Lys Glu 
        275                 280                 285             


Tyr Thr Ser Trp Lys Ser Pro Ala Lys Lys Leu Thr Asn Ala Leu Ser 
    290                 295                 300                 


Lys Ser Leu Ser Cys Ala Ser Ser Arg Glu Pro Leu His Pro Met Phe 
305                 310                 315                 320 


Pro Asp Gln Pro Glu Lys Pro Leu Asn Leu Ala His Ile Val Pro Pro 
                325                 330                 335     


Arg Pro Val Thr Ser Met Asn Asp Thr Leu Phe Ser His Ser Val Pro 
            340                 345                 350         


Ser Ser Gly Ser Pro Phe Ile Thr Arg Ser Ser Asp Gly Ala Phe Gly 
        355                 360                 365             


Gly Cys Val 
    370     


<210>  1366
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  1366

Met Arg Ala Pro Ile Pro Glu Pro Lys Pro Gly Asp Leu Ile Glu Ile 
1               5                   10                  15      


Phe Arg Pro Phe Tyr Arg His Trp Ala Ile Tyr Val Gly Asp Gly Tyr 
            20                  25                  30          


Val Val His Leu Ala Pro Pro Ser Glu Val Ala Gly Ala Gly Ala Ala 
        35                  40                  45              


Ser Val Met Ser Ala Leu Thr Asp Lys Ala Ile Val Lys Lys Glu Leu 
    50                  55                  60                  


Leu Tyr Asp Val Ala Gly Ser Asp Lys Tyr Gln Val Asn Asn Lys His 
65                  70                  75                  80  


Asp Asp Lys Tyr Ser Pro Leu Pro Cys Ser Lys Ile Ile Gln Arg Ala 
                85                  90                  95      


Glu Glu Leu Val Gly Gln Glu Val Leu Tyr Lys Leu Thr Ser Glu Asn 
            100                 105                 110         


Cys Glu His Phe Val Asn Glu Leu Arg Tyr Gly Val Ala Arg Ser Asp 
        115                 120                 125             


Gln Val Arg Asp Val Ile Ile Ala Ala Ser Val Ala Gly Met Gly Leu 
    130                 135                 140                 


Ala Ala Met Ser Leu Ile Gly Val Met Phe Ser Arg Asn Lys Arg Gln 
145                 150                 155                 160 


Lys Gln 
        


<210>  1367
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  1367

Met Ala Gly Ile Lys Ala Leu Ile Ser Leu Ser Phe Gly Gly Ala Ile 
1               5                   10                  15      


Gly Leu Met Phe Leu Met Leu Gly Cys Ala Leu Pro Ile Tyr Asn Lys 
            20                  25                  30          


Tyr Trp Pro Leu Phe Val Leu Phe Phe Tyr Ile Leu Ser Pro Ile Pro 
        35                  40                  45              


Tyr Cys Ile Ala Arg Arg Leu Val Asp Asp Thr Asp Ala Met Ser Asn 
    50                  55                  60                  


Ala Cys Lys Glu Leu Ala Ile Phe Leu Thr Thr Gly Ile Val Val Ser 
65                  70                  75                  80  


Ala Phe Gly Leu Pro Ile Val Phe Ala Arg Ala His Leu Met Gly Arg 
                85                  90                  95      


Leu Pro Phe Phe Ser Lys Met Gly Thr Ala Glu Ser Glu Gly Arg Glu 
            100                 105                 110         


Thr Leu Thr Gln Gln Leu Pro Leu Pro Ala Ala Ala Met Arg Arg Leu 
        115                 120                 125             


Leu Pro Ala Ser Arg Val Ser Thr Gln Pro Val Leu Arg Leu Ala Asp 
    130                 135                 140                 


Ser Ala Glu Ser Leu Leu Gly Arg Pro Ala Leu Trp Ala Leu Gly Phe 
145                 150                 155                 160 


Leu Leu Cys Pro Pro Ser Gln Ala Gln 
                165                 


<210>  1368
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  1368

Met Pro Gln Glu Gln Tyr Thr His His Arg Ser Thr Met Pro Gly Ser 
1               5                   10                  15      


Val Gly Pro Gln Val Tyr Lys Val Gly Ile Tyr Gly Trp Arg Lys Arg 
            20                  25                  30          


Cys Leu Tyr Phe Phe Val Leu Leu Leu Met Ile Leu Ile Leu Val Asn 
        35                  40                  45              


Leu Ala Met Thr Ile Trp Ile Leu Lys Val Met Asn Phe Thr Ile Asp 
    50                  55                  60                  


Gly Met Gly Asn Leu Arg Ile Thr Glu Lys Gly Leu Lys Leu Glu Gly 
65                  70                  75                  80  


Asp Ser Glu Phe Leu Gln Pro Leu Tyr Ala Lys Glu Ile Gln Ser Arg 
                85                  90                  95      


Pro Gly Asn Ala Leu Tyr Phe Lys Ser Ala Arg Asn Val Thr Val Asn 
            100                 105                 110         


Ile Leu Asn Asp Gln Thr Lys Val Leu Thr Gln Leu Ile Thr Gly Pro 
        115                 120                 125             


Lys Ala Val Glu Ala Tyr Gly Lys Lys Phe Glu Val Lys Thr Val Ser 
    130                 135                 140                 


Gly Lys Leu Leu Phe Ser Ala Asp Asn Asn Glu Val Val Val Gly Ala 
145                 150                 155                 160 


Glu Arg Leu Arg Val Leu Gly Ala Glu Gly Thr Val Phe Pro Lys Ser 
                165                 170                 175     


Ile Glu Thr Pro Asn Val Arg Ala Asp Pro Phe Lys Glu Leu Arg Leu 
            180                 185                 190         


Glu Ser Pro Thr Arg Ser Leu Val Met Glu Ala Pro Lys Gly Val Glu 
        195                 200                 205             


Ile Asn Ala Glu Ala Gly Asn Met Glu Ala Thr Cys Arg Thr Glu Leu 
    210                 215                 220                 


Arg Leu Glu Ser Lys Asp Gly Glu Ile Lys Leu Asp Ala Ala Lys Ile 
225                 230                 235                 240 


Arg Leu Pro Arg Leu Pro His Gly Ser Tyr Thr Pro Thr Gly Thr Arg 
                245                 250                 255     


Gln Lys Val Phe Glu Ile Cys Val Cys Ala Asn Gly Arg Leu Phe Leu 
            260                 265                 270         


Ser Gln Ala Gly Ala Gly Ser Thr Cys Gln Ile Asn Thr Ser Val Cys 
        275                 280                 285             


Leu 
    


<210>  1369
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  1369

Met Lys Arg Gly Thr Ser Leu His Ser Arg Arg Gly Lys Pro Glu Ala 
1               5                   10                  15      


Pro Lys Gly Ser Pro Gln Ile Asn Arg Lys Ser Gly Gln Glu Met Thr 
            20                  25                  30          


Ala Val Met Gln Ser Gly Arg Pro Arg Ser Ser Ser Thr Thr Asp Ala 
        35                  40                  45              


Pro Thr Ser Ser Ala Met Met Glu Ile Ala Cys Ala Ala Ala Ala Ala 
    50                  55                  60                  


Ala Ala Ala Cys Leu Pro Gly Glu Glu Gly Thr Ala Glu Arg Ile Glu 
65                  70                  75                  80  


Arg Leu Glu Val Ser Ser Leu Ala Gln Thr Ser Ser Ala Val Ala Ser 
                85                  90                  95      


Ser Thr Asp Gly Ser Ile His Thr Asp Ser Val Asp Gly Thr Pro Asp 
            100                 105                 110         


Pro Gln Arg Thr Lys Ala Ala Ile Ala His Leu Gln Gln Lys Ile Leu 
        115                 120                 125             


Lys Leu Thr Glu Gln Ile Lys Ile Ala Gln Thr Ala Arg Asp Asp Asn 
    130                 135                 140                 


Val Ala Glu Tyr Leu Lys Leu Ala Asn Ser Ala Asp Lys Gln Gln Ala 
145                 150                 155                 160 


Ala Arg Ile Lys Gln Val Phe Glu Lys Lys Asn Gln Lys Ser Ala Gln 
                165                 170                 175     


Thr Ile Leu Gln Leu Gln Lys Lys Leu Glu His Tyr His Arg Lys Leu 
            180                 185                 190         


Arg Glu Val Glu Gln Asn Gly Ile Pro Arg Gln Pro Lys Asp Val Phe 
        195                 200                 205             


Arg Asp Met His Gln Gly Leu Lys Asp Val Gly Ala Lys Val Thr Gly 
    210                 215                 220                 


Phe Ser Glu Gly Val Val Asp Ser Val Lys Gly Gly Phe Ser Ser Phe 
225                 230                 235                 240 


Ser Gln Ala Thr His Ser Ala Ala Gly Ala Val Val Ser Lys Pro Arg 
                245                 250                 255     


Glu Ile Ala Ser Leu Ile Arg Asn Lys Phe Gly Ser Ala Asp Asn Ile 
            260                 265                 270         


Pro Asn Leu Lys Asp Ser Leu Glu Glu Gly Gln Val Asp Asp Ala Gly 
        275                 280                 285             


Lys Ala Leu Gly Val Ile Ser Asn Phe Gln Ser Ser Pro Lys Tyr Gly 
    290                 295                 300                 


Ser Glu Glu Asp Cys Ser Ser Ala Thr Ser Gly Ser Val Gly Ala Asn 
305                 310                 315                 320 


Ser Thr Thr Gly Gly Ile Ala Val Gly Ala Ser Ser Ser Lys Thr Asn 
                325                 330                 335     


Thr Leu Asp Met Gln Ser Ser Gly Phe Asp Ala Leu Leu His Glu Ile 
            340                 345                 350         


Gln Glu Ile Arg Glu Thr Gln Ala Arg Leu Glu Glu Ser Phe Glu Thr 
        355                 360                 365             


Leu Lys Glu His Tyr Gln Arg Asp Tyr Ser Leu Ile Met Gln Thr Leu 
    370                 375                 380                 


Gln Glu Glu Arg Tyr Arg Cys Glu Arg Leu Glu Glu Gln Leu Asn Asp 
385                 390                 395                 400 


Leu Thr Glu Leu His Gln Asn Glu Ile Leu Asn Leu Lys Gln Glu Leu 
                405                 410                 415     


Ala Ser Met Glu Glu Lys Ile Ala Tyr Gln Ser Tyr Glu Arg Ala Arg 
            420                 425                 430         


Asp Ile Gln Glu Ala Leu Glu Ala Cys Gln Thr Arg Ile Ser Lys Met 
        435                 440                 445             


Glu Leu Gln Gln Gln Gln Gln Gln Val Val Gln Leu Glu Gly Leu Glu 
    450                 455                 460                 


Asn Ala Thr Ala Arg Asn Leu Leu Gly Lys Leu Ile Asn Ile Leu Leu 
465                 470                 475                 480 


Ala Val Met Ala Val Leu Leu Val Phe Val Ser Thr Val Ala Asn Cys 
                485                 490                 495     


Val Val Pro Leu Met Lys Thr Arg Asn Arg Thr Phe Ser Thr Leu Phe 
            500                 505                 510         


Leu Val Val Phe Ile Ala Phe Leu Trp Lys His Trp Asp Ala Leu Phe 
        515                 520                 525             


Ser Tyr Val Glu Arg Phe Phe Ser Ser Pro Arg 
    530                 535                 


<210>  1370
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  1370

Met Pro Gly Cys Pro Cys Pro Gly Cys Gly Met Ala Gly Pro Arg Leu 
1               5                   10                  15      


Leu Phe Leu Thr Ala Leu Ala Leu Glu Leu Leu Gly Arg Ala Gly Gly 
            20                  25                  30          


Ser Gln Pro Ala Leu Arg Ser Arg Gly Thr Ala Thr Ala Cys Arg Leu 
        35                  40                  45              


Asp Asn Lys Glu Ser Glu Ser Trp Gly Ala Leu Leu Ser Gly Glu Arg 
    50                  55                  60                  


Leu Asp Thr Trp Ile Cys Ser Leu Leu Gly Ser Leu Met Val Gly Leu 
65                  70                  75                  80  


Ser Gly Val Phe Pro Leu Leu Val Ile Pro Leu Glu Met Gly Thr Met 
                85                  90                  95      


Leu Arg Ser Glu Ala Gly Ala Trp Arg Leu Lys Gln Leu Leu Ser Phe 
            100                 105                 110         


Ala Leu Gly Gly Leu Leu Gly Asn Val Phe Leu His Leu Leu Pro Glu 
        115                 120                 125             


Ala Trp Ala Tyr Thr Cys Ser Ala Ser Pro Gly Gly Glu Gly Gln Ser 
    130                 135                 140                 


Leu Gln Gln Gln Gln Gln Leu Gly Leu Trp Val Ile Ala Gly Ile Leu 
145                 150                 155                 160 


Thr Phe Leu Ala Leu Glu Lys Met Phe Leu Asp Ser Lys Glu Glu Gly 
                165                 170                 175     


Thr Ser Gln Ala Pro Asn Lys Asp Pro Thr Ala Ala Ala Ala Ala Leu 
            180                 185                 190         


Asn Gly Gly His Cys Leu Ala Gln Pro Ala Ala Glu Pro Gly Leu Gly 
        195                 200                 205             


Ala Val Val Arg Ser Ile Lys Val Ser Gly Tyr Leu Asn Leu Leu Ala 
    210                 215                 220                 


Asn Thr Ile Asp Asn Phe Thr His Gly Leu Ala Val Ala Ala Ser Phe 
225                 230                 235                 240 


Leu Val Ser Lys Lys Ile Gly Leu Leu Thr Thr Met Ala Ile Leu Leu 
                245                 250                 255     


His Glu Ile Pro His Glu Val Gly Asp Phe Ala Ile Leu Leu Arg Ala 
            260                 265                 270         


Gly Phe Asp Arg Trp Ser Ala Ala Lys Leu Gln Leu Ser Thr Ala Leu 
        275                 280                 285             


Gly Gly Leu Leu Gly Ala Gly Phe Ala Ile Cys Thr Gln Ser Pro Lys 
    290                 295                 300                 


Gly Val Val Gly Cys Ser Pro Ala Ala Glu Glu Thr Ala Ala Trp Val 
305                 310                 315                 320 


Leu Pro Phe Thr Ser Gly Gly Phe Leu Tyr Ile Ala Leu Val Asn Val 
                325                 330                 335     


Leu Pro Asp Leu Leu Glu Glu Glu Asp Pro Trp Arg Ser Leu Gln Gln 
            340                 345                 350         


Leu Leu Leu Leu Cys Ala Gly Ile Val Val Met Val Leu Phe Ser Leu 
        355                 360                 365             


Phe Val Asp 
    370     


<210>  1371
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  1371

Met His Tyr Tyr Arg Tyr Ser Asn Ala Lys Val Ser Cys Trp Tyr Lys 
1               5                   10                  15      


Tyr Leu Leu Phe Ser Tyr Asn Ile Ile Phe Trp Asn Gln Cys Cys Gly 
            20                  25                  30          


Ala Tyr Gly Pro Glu Asp Trp Asp Leu Asn Val Tyr Phe Asn Cys Ser 
        35                  40                  45              


Gly Ala Ser Tyr Ser Arg Glu Lys Cys Gly Val Pro Phe Ser Cys Cys 
    50                  55                  60                  


Val Pro Asp Pro Ala Gln Lys Val Val Asn Thr Gln Cys Gly Tyr Asp 
65                  70                  75                  80  


Val Arg Ile Gln Leu Lys Ser Lys Trp Asp Glu Ser Ile Phe Thr Lys 
                85                  90                  95      


Gly Cys Ile Gln Ala Leu Glu Ser Trp Leu Pro Arg Asn Ile Tyr Ile 
            100                 105                 110         


Val Ala Gly Val Phe Ile Ala Ile Ser Leu Leu Gln Ile Phe Gly Ile 
        115                 120                 125             


Phe Leu Ala Arg Thr Leu Ile Ser Asp Ile Glu Ala Val Lys Ala Gly 
    130                 135                 140                 


His His Phe 
145         


<210>  1372
<211>  519
<212>  PRT
<213>  Homo sapiens

<400>  1372

Met Thr Cys Pro Asp Lys Pro Gly Gln Leu Ile Asn Trp Phe Ile Cys 
1               5                   10                  15      


Ser Leu Cys Val Pro Arg Val Arg Lys Leu Trp Ser Ser Arg Arg Pro 
            20                  25                  30          


Arg Thr Arg Arg Asn Leu Leu Leu Gly Thr Ala Cys Ala Ile Tyr Leu 
        35                  40                  45              


Gly Phe Leu Val Ser Gln Val Gly Arg Ala Ser Leu Gln His Gly Gln 
    50                  55                  60                  


Ala Ala Glu Lys Gly Pro His Arg Ser Arg Asp Thr Ala Glu Pro Ser 
65                  70                  75                  80  


Phe Pro Glu Ile Pro Leu Asp Gly Thr Leu Ala Pro Pro Glu Ser Gln 
                85                  90                  95      


Gly Asn Gly Ser Thr Leu Gln Pro Asn Val Val Tyr Ile Thr Leu Arg 
            100                 105                 110         


Ser Lys Arg Ser Lys Pro Ala Asn Ile Arg Gly Thr Val Lys Pro Lys 
        115                 120                 125             


Arg Arg Lys Lys His Ala Val Ala Ser Ala Ala Pro Gly Gln Glu Ala 
    130                 135                 140                 


Leu Val Gly Pro Ser Leu Gln Pro Gln Glu Ala Ala Arg Glu Ala Asp 
145                 150                 155                 160 


Ala Val Ala Pro Gly Tyr Ala Gln Gly Ala Asn Leu Val Lys Ile Gly 
                165                 170                 175     


Glu Arg Pro Trp Arg Leu Val Arg Gly Pro Gly Val Arg Ala Gly Gly 
            180                 185                 190         


Pro Asp Phe Leu Gln Pro Ser Ser Arg Glu Ser Asn Ile Arg Ile Tyr 
        195                 200                 205             


Ser Glu Ser Ala Pro Ser Trp Leu Ser Lys Asp Asp Ile Arg Arg Met 
    210                 215                 220                 


Arg Leu Leu Ala Asp Ser Ala Val Ala Gly Leu Arg Pro Val Ser Ser 
225                 230                 235                 240 


Arg Ser Gly Ala Arg Leu Leu Val Leu Glu Gly Gly Ala Pro Gly Ala 
                245                 250                 255     


Val Leu Arg Cys Gly Pro Ser Pro Cys Gly Leu Leu Lys Gln Pro Leu 
            260                 265                 270         


Asp Met Ser Glu Val Phe Ala Phe His Leu Asp Arg Ile Leu Gly Leu 
        275                 280                 285             


Asn Arg Thr Leu Pro Ser Val Ser Arg Lys Ala Glu Phe Ile Gln Asp 
    290                 295                 300                 


Gly Arg Pro Cys Pro Ile Ile Leu Trp Asp Ala Ser Leu Ser Ser Ala 
305                 310                 315                 320 


Ser Asn Asp Thr His Ser Ser Val Lys Leu Thr Trp Gly Thr Tyr Gln 
                325                 330                 335     


Gln Leu Leu Lys Gln Lys Cys Trp Gln Asn Gly Arg Val Pro Lys Pro 
            340                 345                 350         


Glu Ser Gly Cys Thr Glu Ile His His His Glu Trp Ser Lys Met Ala 
        355                 360                 365             


Leu Phe Asp Phe Leu Leu Gln Ile Tyr Asn Arg Leu Asp Thr Asn Cys 
    370                 375                 380                 


Cys Gly Phe Arg Pro Arg Lys Glu Asp Ala Cys Val Gln Asn Gly Leu 
385                 390                 395                 400 


Arg Pro Lys Cys Asp Asp Gln Gly Ser Ala Ala Leu Ala His Ile Ile 
                405                 410                 415     


Gln Arg Lys His Asp Pro Arg His Leu Val Phe Ile Asp Asn Lys Gly 
            420                 425                 430         


Phe Phe Asp Arg Ser Glu Asp Asn Leu Asn Phe Lys Leu Leu Glu Gly 
        435                 440                 445             


Ile Lys Glu Phe Pro Ala Ser Ala Val Ser Val Leu Lys Ser Gln His 
    450                 455                 460                 


Leu Arg Gln Lys Leu Leu Gln Ser Leu Phe Leu Asp Lys Val Tyr Trp 
465                 470                 475                 480 


Glu Ser Gln Gly Gly Arg Gln Gly Ile Glu Lys Leu Ile Asp Val Ile 
                485                 490                 495     


Glu His Arg Ala Lys Ile Leu Ile Thr Tyr Ile Asn Ala His Gly Val 
            500                 505                 510         


Lys Val Leu Pro Met Asn Glu 
        515                 


<210>  1373
<211>  492
<212>  PRT
<213>  Homo sapiens

<400>  1373

Met Lys Leu Leu Leu Leu His Pro Ala Phe Gln Ser Cys Leu Leu Leu 
1               5                   10                  15      


Thr Leu Leu Gly Leu Trp Arg Thr Thr Pro Glu Ala His Ala Ser Ser 
            20                  25                  30          


Leu Gly Ala Pro Ala Ile Ser Ala Ala Ser Phe Leu Gln Asp Leu Ile 
        35                  40                  45              


His Arg Tyr Gly Glu Gly Asp Ser Leu Thr Leu Gln Gln Leu Lys Ala 
    50                  55                  60                  


Leu Leu Asn His Leu Asp Val Gly Val Gly Arg Gly Asn Val Thr Gln 
65                  70                  75                  80  


His Val Gln Gly His Arg Asn Leu Ser Thr Cys Phe Ser Ser Gly Asp 
                85                  90                  95      


Leu Phe Thr Ala His Asn Phe Ser Glu Gln Ser Arg Ile Gly Ser Ser 
            100                 105                 110         


Glu Leu Gln Glu Phe Cys Pro Thr Ile Leu Gln Gln Leu Asp Ser Arg 
        115                 120                 125             


Ala Cys Thr Ser Glu Asn Gln Glu Asn Glu Glu Asn Glu Gln Thr Glu 
    130                 135                 140                 


Glu Gly Arg Pro Ser Ala Val Glu Val Trp Gly Tyr Gly Leu Leu Cys 
145                 150                 155                 160 


Val Thr Val Ile Ser Leu Cys Ser Leu Leu Gly Ala Ser Val Val Pro 
                165                 170                 175     


Phe Met Lys Lys Thr Phe Tyr Lys Arg Leu Leu Leu Tyr Phe Ile Ala 
            180                 185                 190         


Leu Ala Ile Gly Thr Leu Tyr Ser Asn Ala Leu Phe Gln Leu Ile Pro 
        195                 200                 205             


Glu Ala Phe Gly Phe Asn Pro Leu Glu Asp Tyr Tyr Val Ser Lys Ser 
    210                 215                 220                 


Ala Val Val Phe Gly Gly Phe Tyr Leu Phe Phe Phe Thr Glu Lys Ile 
225                 230                 235                 240 


Leu Lys Ile Leu Leu Lys Gln Lys Asn Glu His His His Gly His Ser 
                245                 250                 255     


His Tyr Ala Ser Glu Ser Leu Pro Ser Lys Lys Asp Gln Glu Glu Gly 
            260                 265                 270         


Val Met Glu Lys Leu Gln Asn Gly Asp Leu Asp His Met Ile Pro Gln 
        275                 280                 285             


His Cys Ser Ser Glu Leu Asp Gly Lys Ala Pro Met Val Asp Glu Lys 
    290                 295                 300                 


Val Ile Val Gly Ser Leu Ser Val Gln Asp Leu Gln Ala Ser Gln Ser 
305                 310                 315                 320 


Ala Cys Tyr Trp Leu Lys Gly Val Arg Tyr Ser Asp Ile Gly Thr Leu 
                325                 330                 335     


Ala Trp Met Ile Thr Leu Ser Asp Gly Leu His Asn Phe Ile Asp Gly 
            340                 345                 350         


Leu Ala Ile Gly Ala Ser Phe Thr Val Ser Val Phe Gln Gly Ile Ser 
        355                 360                 365             


Thr Ser Val Ala Ile Leu Cys Glu Glu Phe Pro His Glu Leu Gly Asp 
    370                 375                 380                 


Phe Val Ile Leu Leu Asn Ala Gly Met Ser Ile Gln Gln Ala Leu Phe 
385                 390                 395                 400 


Phe Asn Phe Leu Ser Ala Cys Cys Cys Tyr Leu Gly Leu Ala Phe Gly 
                405                 410                 415     


Ile Leu Ala Gly Ser His Phe Ser Ala Asn Trp Ile Phe Ala Leu Ala 
            420                 425                 430         


Gly Gly Met Phe Leu Tyr Ile Ser Leu Ala Asp Met Phe Pro Glu Met 
        435                 440                 445             


Asn Glu Val Cys Gln Glu Asp Glu Arg Lys Gly Ser Ile Leu Ile Pro 
    450                 455                 460                 


Phe Ile Ile Gln Asn Leu Gly Leu Leu Thr Gly Phe Thr Ile Met Val 
465                 470                 475                 480 


Val Leu Thr Met Tyr Ser Gly Gln Ile Gln Ile Gly 
                485                 490         


<210>  1374
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  1374

Met Asn Gly Arg Ser Leu Ile Gly Gly Ala Gly Asp Ala Arg His Gly 
1               5                   10                  15      


Pro Val Trp Lys Asp Pro Phe Gly Thr Lys Ala Gly Asp Ala Ala Arg 
            20                  25                  30          


Arg Gly Ile Ala Arg Leu Ser Leu Ala Leu Ala Asp Gly Ser Gln Glu 
        35                  40                  45              


Gln Glu Pro Glu Glu Glu Ile Ala Met Glu Asp Ser Pro Thr Met Val 
    50                  55                  60                  


Arg Val Asp Ser Pro Thr Met Val Arg Gly Glu Asn Gln Val Ser Pro 
65                  70                  75                  80  


Cys Gln Gly Arg Arg Cys Phe Pro Lys Ala Leu Gly Tyr Val Thr Gly 
                85                  90                  95      


Asp Met Lys Glu Leu Ala Asn Gln Leu Lys Asp Lys Pro Val Val Leu 
            100                 105                 110         


Gln Phe Ile Asp Trp Ile Leu Arg Gly Ile Ser Gln Val Val Phe Val 
        115                 120                 125             


Asn Asn Pro Val Ser Gly Ile Leu Ile Leu Val Gly Leu Leu Val Gln 
    130                 135                 140                 


Asn Pro Trp Trp Ala Leu Thr Gly Trp Leu Gly Thr Val Val Ser Thr 
145                 150                 155                 160 


Leu Met Ala Leu Leu Leu Ser Gln Asp Arg Ser Leu Ile Ala Ser Gly 
                165                 170                 175     


Leu Tyr Gly Tyr Asn Ala Thr Leu Val Gly Val Leu Met Ala Val Phe 
            180                 185                 190         


Ser Asp Lys Gly Asp Tyr Phe Trp Trp Leu Leu Leu Pro Val Cys Ala 
        195                 200                 205             


Met Ser Met Thr Cys Pro Ile Phe Ser Ser Ala Leu Asn Ser Met Leu 
    210                 215                 220                 


Ser Lys Trp Asp Leu Pro Val Phe Thr Leu Pro Phe Asn Met Ala Leu 
225                 230                 235                 240 


Ser Met Tyr Leu Ser Ala Thr Gly His Tyr Asn Pro Phe Phe Pro Ala 
                245                 250                 255     


Lys Leu Val Ile Pro Ile Thr Thr Ala Pro Asn Ile Ser Trp Ser Asp 
            260                 265                 270         


Leu Ser Ala Leu Glu Leu Leu Lys Ser Ile Pro Val Gly Val Gly Gln 
        275                 280                 285             


Ile Tyr Gly Cys Asp Asn Pro Trp Thr Gly Gly Ile Phe Leu Gly Ala 
    290                 295                 300                 


Ile Leu Leu Ser Ser Pro Leu Met Cys Leu His Ala Ala Ile Gly Ser 
305                 310                 315                 320 


Leu Leu Gly Ile Ala Ala Gly Leu Ser Leu Ser Ala Pro Phe Glu Asp 
                325                 330                 335     


Ile Tyr Phe Gly Leu Trp Gly Phe Asn Ser Ser Leu Ala Cys Ile Ala 
            340                 345                 350         


Met Gly Gly Met Phe Met Ala Leu Thr Trp Gln Thr His Leu Leu Ala 
        355                 360                 365             


Leu Gly Cys Ala Leu Phe Thr Ala Tyr Leu Gly Val Gly Met Ala Asn 
    370                 375                 380                 


Phe Met Ala Glu Val Gly Leu Pro Ala Cys Thr Trp Pro Phe Cys Leu 
385                 390                 395                 400 


Ala Thr Leu Leu Phe Leu Ile Met Thr Thr Lys Asn Ser Asn Ile Tyr 
                405                 410                 415     


Lys Met Pro Leu Ser Lys Val Thr Tyr Pro Glu Glu Asn Arg Ile Phe 
            420                 425                 430         


Tyr Leu Gln Ala Lys Lys Arg Met Val Glu Ser Pro Leu 
        435                 440                 445 


<210>  1375
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  1375

Met Lys Lys Ile Glu Ile Ser Gly Thr Cys Leu Ser Phe His Leu Leu 
1               5                   10                  15      


Phe Gly Leu Glu Ile Arg Met Arg Arg Ile Val Phe Ala Gly Val Ile 
            20                  25                  30          


Leu Phe Arg Leu Leu Gly Val Ile Leu Phe Arg Leu Leu Gly Val Ile 
        35                  40                  45              


Leu Phe Gly Arg Leu Gly Asp Leu Gly Thr Cys Gln Thr Lys Pro Gly 
    50                  55                  60                  


Gln Tyr Trp Lys Glu Glu Val His Ile Gln Asp Val Gly Gly Leu Ile 
65                  70                  75                  80  


Cys Arg Ala Cys Asn Leu Ser Leu Pro Phe His Gly Cys Leu Leu Asp 
                85                  90                  95      


Leu Gly Thr Cys Gln Ala Glu Pro Gly Gln Tyr Cys Lys Glu Glu Val 
            100                 105                 110         


His Ile Gln Gly Gly Ile Gln Trp Tyr Ser Val Lys Gly Cys Thr Lys 
        115                 120                 125             


Asn Thr Ser Glu Cys Phe Lys Ser Thr Leu Val Lys Arg Ile Leu Gln 
    130                 135                 140                 


Leu His Glu Leu Val Thr Thr His Cys Cys Asn His Ser Leu Cys Asn 
145                 150                 155                 160 


Phe 
    


<210>  1376
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  1376

Met Gly Leu Leu Glu Cys Cys Ala Arg Cys Leu Val Gly Ala Pro Phe 
1               5                   10                  15      


Ala Ser Leu Val Ala Thr Gly Leu Cys Phe Phe Gly Val Ala Leu Phe 
            20                  25                  30          


Cys Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu 
        35                  40                  45              


Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val 
    50                  55                  60                  


Ile His Ala Phe Gln Tyr Val Ile Tyr Gly Thr Ala Ser Phe Phe Phe 
65                  70                  75                  80  


Leu Tyr Gly Ala Leu Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly Ala 
                85                  90                  95      


Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys Gly 
            100                 105                 110         


Leu Ser Ala Thr Val Thr Gly Gly Gln Lys Gly Arg Gly Ser Arg Gly 
        115                 120                 125             


Gln His Gln Ala His Ser Leu Glu Arg Val Cys His Cys Leu Gly Lys 
    130                 135                 140                 


Trp Leu Gly His Pro Asp Lys Phe Val Gly Ile Thr Tyr Ala Leu Thr 
145                 150                 155                 160 


Val Val Trp Leu Leu Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile 
                165                 170                 175     


Tyr Phe Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys 
            180                 185                 190         


Thr Ser Ala Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly 
        195                 200                 205             


Val Leu Pro Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn Leu 
    210                 215                 220                 


Leu Ser Ile Cys Lys Thr Ala Glu Phe Gln Met Thr Phe His Leu Phe 
225                 230                 235                 240 


Ile Ala Ala Phe Val Gly Ala Ala Ala Thr Leu Val Ser Leu Leu Thr 
                245                 250                 255     


Phe Met Ile Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly 
            260                 265                 270         


Arg Gly Thr Lys Phe 
        275         


<210>  1377
<211>  2137
<212>  PRT
<213>  Homo sapiens

<400>  1377

Met Met Met Met Met Met Met Lys Lys Met Gln His Gln Arg Gln Gln 
1               5                   10                  15      


Gln Ala Asp His Ala Asn Glu Ala Asn Tyr Ala Arg Gly Thr Arg Leu 
            20                  25                  30          


Pro Leu Ser Gly Glu Gly Pro Thr Ser Gln Pro Asn Ser Ser Lys Gln 
        35                  40                  45              


Thr Val Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys 
    50                  55                  60                  


Ala Ala Gln Thr Met Ser Thr Ser Ala Pro Pro Pro Val Gly Ser Leu 
65                  70                  75                  80  


Ser Gln Arg Lys Arg Gln Gln Tyr Ala Lys Ser Lys Lys Gln Gly Asn 
                85                  90                  95      


Ser Ser Asn Ser Arg Pro Ala Arg Ala Leu Phe Cys Leu Ser Leu Asn 
            100                 105                 110         


Asn Pro Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe 
        115                 120                 125             


Asp Ile Phe Ile Leu Leu Ala Ile Phe Ala Asn Cys Val Ala Leu Ala 
    130                 135                 140                 


Ile Tyr Ile Pro Phe Pro Glu Asp Asp Ser Asn Ser Thr Asn His Asn 
145                 150                 155                 160 


Leu Glu Lys Val Glu Tyr Ala Phe Leu Ile Ile Phe Thr Val Glu Thr 
                165                 170                 175     


Phe Leu Lys Ile Ile Ala Tyr Gly Leu Leu Leu His Pro Asn Ala Tyr 
            180                 185                 190         


Val Arg Asn Gly Trp Asn Leu Leu Asp Phe Val Ile Val Ile Val Gly 
        195                 200                 205             


Leu Phe Ser Val Ile Leu Glu Gln Leu Thr Lys Glu Thr Glu Gly Gly 
    210                 215                 220                 


Asn His Ser Ser Gly Lys Ser Gly Gly Phe Asp Val Lys Ala Leu Arg 
225                 230                 235                 240 


Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser 
                245                 250                 255     


Leu Gln Val Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu 
            260                 265                 270         


His Ile Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile 
        275                 280                 285             


Gly Leu Glu Leu Phe Ile Gly Lys Met His Lys Thr Cys Phe Phe Ala 
    290                 295                 300                 


Asp Ser Asp Ile Val Ala Glu Glu Asp Pro Ala Pro Cys Ala Phe Ser 
305                 310                 315                 320 


Gly Asn Gly Arg Gln Cys Thr Ala Asn Gly Thr Glu Cys Arg Ser Gly 
                325                 330                 335     


Trp Val Gly Pro Asn Gly Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe 
            340                 345                 350         


Ala Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp 
        355                 360                 365             


Val Leu Tyr Trp Met Asn Asp Ala Met Gly Phe Glu Leu Pro Trp Val 
    370                 375                 380                 


Tyr Phe Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu 
385                 390                 395                 400 


Val Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala 
                405                 410                 415     


Lys Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu 
            420                 425                 430         


Glu Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile 
        435                 440                 445             


Asp Pro Glu Asn Glu Glu Glu Gly Gly Glu Glu Gly Lys Arg Asn Thr 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ser 
465                 470                 475                 480 


Gly Glu Gly Glu Asn Arg Gly Cys Cys Gly Ser Leu Cys Gln Ala Ile 
                485                 490                 495     


Ser Lys Ser Lys Leu Ser Arg Arg Trp Arg Arg Trp Asn Arg Phe Asn 
            500                 505                 510         


Arg Arg Arg Cys Arg Ala Ala Val Lys Ser Val Thr Phe Tyr Trp Leu 
        515                 520                 525             


Val Ile Val Leu Val Phe Leu Asn Thr Leu Thr Ile Ser Ser Glu His 
    530                 535                 540                 


Tyr Asn Gln Pro Asp Trp Leu Thr Gln Ile Gln Asp Ile Ala Asn Lys 
545                 550                 555                 560 


Val Leu Leu Ala Leu Phe Thr Cys Glu Met Leu Val Lys Met Tyr Ser 
                565                 570                 575     


Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp Cys 
            580                 585                 590         


Phe Val Val Cys Gly Gly Ile Thr Glu Thr Ile Leu Val Glu Leu Glu 
        595                 600                 605             


Ile Met Ser Pro Leu Gly Ile Ser Val Phe Arg Cys Val Arg Leu Leu 
    610                 615                 620                 


Arg Ile Phe Lys Val Thr Arg His Trp Thr Ser Leu Ser Asn Leu Val 
625                 630                 635                 640 


Ala Ser Leu Leu Asn Ser Met Lys Ser Ile Ala Ser Leu Leu Leu Leu 
                645                 650                 655     


Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu Phe 
            660                 665                 670         


Gly Gly Lys Phe Asn Phe Asp Glu Thr Gln Thr Lys Arg Ser Thr Phe 
        675                 680                 685             


Asp Asn Phe Pro Gln Ala Leu Leu Thr Val Phe Gln Ile Leu Thr Gly 
    690                 695                 700                 


Glu Asp Trp Asn Ala Val Met Tyr Asp Gly Ile Met Ala Tyr Gly Gly 
705                 710                 715                 720 


Pro Ser Ser Ser Gly Met Ile Val Cys Ile Tyr Phe Ile Ile Leu Phe 
                725                 730                 735     


Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala Val 
            740                 745                 750         


Asp Asn Leu Ala Asp Ala Glu Ser Leu Asn Thr Ala Gln Lys Glu Glu 
        755                 760                 765             


Ala Glu Glu Lys Glu Arg Lys Lys Ile Ala Arg Lys Glu Ser Leu Glu 
    770                 775                 780                 


Asn Lys Lys Asn Asn Lys Pro Glu Val Asn Gln Ile Ala Asn Ser Asp 
785                 790                 795                 800 


Asn Lys Val Thr Ile Asp Asp Tyr Arg Glu Glu Asp Glu Asp Lys Asp 
                805                 810                 815     


Pro Tyr Pro Pro Cys Asp Val Pro Val Gly Glu Glu Glu Glu Glu Glu 
            820                 825                 830         


Glu Glu Asp Glu Pro Glu Val Pro Ala Gly Pro Arg Pro Arg Arg Ile 
        835                 840                 845             


Ser Glu Leu Asn Met Lys Glu Lys Ile Ala Pro Ile Pro Glu Gly Ser 
    850                 855                 860                 


Ala Phe Phe Ile Leu Ser Lys Thr Asn Pro Ile Arg Val Gly Cys His 
865                 870                 875                 880 


Lys Leu Ile Asn His His Ile Phe Thr Asn Leu Ile Leu Val Phe Ile 
                885                 890                 895     


Met Leu Ser Ser Ala Ala Leu Ala Ala Glu Asp Pro Ile Arg Ser His 
            900                 905                 910         


Ser Phe Arg Asn Thr Ile Leu Gly Tyr Phe Asp Tyr Ala Phe Thr Ala 
        915                 920                 925             


Ile Phe Thr Val Glu Ile Leu Leu Lys Met Thr Thr Phe Gly Ala Phe 
    930                 935                 940                 


Leu His Lys Gly Ala Phe Cys Arg Asn Tyr Phe Asn Leu Leu Asp Met 
945                 950                 955                 960 


Leu Val Val Gly Val Ser Leu Val Ser Phe Gly Ile Gln Ser Ser Ala 
                965                 970                 975     


Ile Ser Val Val Lys Ile Leu Arg Val Leu Arg Val Leu Arg Pro Leu 
            980                 985                 990         


Arg Ala Ile Asn Arg Ala Lys Gly  Leu Lys His Val Val  Gln Cys Val 
        995                 1000                 1005             


Phe Val  Ala Ile Arg Thr Ile  Gly Asn Ile Met Ile  Val Thr Thr 
    1010                 1015                 1020             


Leu Leu  Gln Phe Met Phe Ala  Cys Ile Gly Val Gln  Leu Phe Lys 
    1025                 1030                 1035             


Gly Lys  Phe Tyr Arg Cys Thr  Asp Glu Ala Lys Ser  Asn Pro Glu 
    1040                 1045                 1050             


Glu Cys  Arg Gly Leu Phe Ile  Leu Tyr Lys Asp Gly  Asp Val Asp 
    1055                 1060                 1065             


Ser Pro  Val Val Arg Glu Arg  Ile Trp Gln Asn Ser  Asp Phe Asn 
    1070                 1075                 1080             


Phe Asp  Asn Val Leu Ser Ala  Met Met Ala Leu Phe  Thr Val Ser 
    1085                 1090                 1095             


Thr Phe  Glu Gly Trp Pro Ala  Leu Leu Tyr Lys Ala  Ile Asp Ser 
    1100                 1105                 1110             


Asn Gly  Glu Asn Ile Gly Pro  Ile Tyr Asn His Arg  Val Glu Ile 
    1115                 1120                 1125             


Ser Ile  Phe Phe Ile Ile Tyr  Ile Ile Ile Val Ala  Phe Phe Met 
    1130                 1135                 1140             


Met Asn  Ile Phe Val Gly Phe  Val Ile Val Thr Phe  Gln Glu Gln 
    1145                 1150                 1155             


Gly Glu  Lys Glu Tyr Lys Asn  Cys Glu Leu Asp Lys  Asn Gln Arg 
    1160                 1165                 1170             


Gln Cys  Val Glu Tyr Ala Leu  Lys Ala Arg Pro Leu  Arg Arg Tyr 
    1175                 1180                 1185             


Ile Pro  Lys Asn Pro Tyr Gln  Tyr Lys Phe Trp Tyr  Val Val Asn 
    1190                 1195                 1200             


Ser Ser  Pro Phe Glu Tyr Met  Met Phe Val Leu Ile  Met Leu Asn 
    1205                 1210                 1215             


Thr Leu  Cys Leu Ala Met Gln  His Tyr Glu Gln Ser  Lys Met Phe 
    1220                 1225                 1230             


Asn Asp  Ala Met Asp Ile Leu  Asn Met Val Phe Thr  Gly Val Phe 
    1235                 1240                 1245             


Thr Val  Glu Met Val Leu Lys  Val Ile Ala Phe Lys  Pro Lys Gly 
    1250                 1255                 1260             


Tyr Phe  Ser Asp Ala Trp Asn  Thr Phe Asp Ser Leu  Ile Val Ile 
    1265                 1270                 1275             


Gly Ser  Ile Ile Asp Val Ala  Leu Ser Glu Ala Asp  Asn Ser Glu 
    1280                 1285                 1290             


Glu Ser  Asn Arg Ile Ser Ile  Thr Phe Phe Arg Leu  Phe Arg Val 
    1295                 1300                 1305             


Met Arg  Leu Val Lys Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Thr 
    1310                 1315                 1320             


Leu Leu  Trp Thr Phe Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val 
    1325                 1330                 1335             


Ala Leu  Leu Ile Ala Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly 
    1340                 1345                 1350             


Met Gln  Met Phe Gly Lys Val  Ala Met Arg Asp Asn  Asn Gln Ile 
    1355                 1360                 1365             


Asn Arg  Asn Asn Asn Phe Gln  Thr Phe Pro Gln Ala  Val Leu Leu 
    1370                 1375                 1380             


Leu Phe  Arg Cys Ala Thr Gly  Glu Ala Trp Gln Glu  Ile Met Leu 
    1385                 1390                 1395             


Ala Cys  Leu Pro Gly Lys Leu  Cys Asp Pro Glu Ser  Asp Tyr Asn 
    1400                 1405                 1410             


Pro Gly  Glu Glu Tyr Thr Cys  Gly Ser Asn Phe Ala  Ile Val Tyr 
    1415                 1420                 1425             


Phe Ile  Ser Phe Tyr Met Leu  Cys Ala Phe Leu Ile  Ile Asn Leu 
    1430                 1435                 1440             


Phe Val  Ala Val Ile Met Asp  Asn Phe Asp Tyr Leu  Thr Arg Asp 
    1445                 1450                 1455             


Trp Ser  Ile Leu Gly Pro His  His Leu Asp Glu Phe  Lys Arg Ile 
    1460                 1465                 1470             


Trp Ser  Glu Tyr Asp Pro Glu  Ala Lys Gly Arg Ile  Lys His Leu 
    1475                 1480                 1485             


Asp Val  Val Thr Leu Leu Arg  Arg Ile Gln Pro Pro  Leu Gly Phe 
    1490                 1495                 1500             


Gly Lys  Leu Cys Pro His Arg  Val Ala Cys Lys Arg  Leu Val Ala 
    1505                 1510                 1515             


Met Asn  Met Pro Leu Asn Ser  Asp Gly Thr Val Met  Phe Asn Ala 
    1520                 1525                 1530             


Thr Leu  Phe Ala Leu Val Arg  Thr Ala Leu Lys Ile  Lys Thr Glu 
    1535                 1540                 1545             


Gly Asn  Leu Glu Gln Ala Asn  Glu Glu Leu Arg Ala  Val Ile Lys 
    1550                 1555                 1560             


Lys Ile  Trp Lys Lys Thr Ser  Met Lys Leu Leu Asp  Gln Val Val 
    1565                 1570                 1575             


Pro Pro  Ala Gly Asp Asp Glu  Val Thr Val Gly Lys  Phe Tyr Ala 
    1580                 1585                 1590             


Thr Phe  Leu Ile Gln Asp Tyr  Phe Arg Lys Phe Lys  Lys Arg Lys 
    1595                 1600                 1605             


Glu Gln  Gly Leu Val Gly Lys  Tyr Pro Ala Lys Asn  Thr Thr Ile 
    1610                 1615                 1620             


Ala Leu  Gln Ala Gly Leu Arg  Thr Leu His Asp Ile  Gly Pro Glu 
    1625                 1630                 1635             


Ile Arg  Arg Ala Ile Ser Cys  Asp Leu Gln Asp Asp  Glu Pro Glu 
    1640                 1645                 1650             


Glu Thr  Lys Arg Glu Glu Glu  Asp Asp Val Phe Lys  Arg Asn Gly 
    1655                 1660                 1665             


Ala Leu  Leu Gly Asn His Val  Asn His Val Asn Ser  Asp Arg Arg 
    1670                 1675                 1680             


Asp Ser  Leu Gln Gln Thr Asn  Thr Thr His Arg Pro  Leu His Val 
    1685                 1690                 1695             


Gln Arg  Pro Ser Ile Pro Pro  Ala Ser Asp Thr Glu  Lys Pro Leu 
    1700                 1705                 1710             


Phe Pro  Pro Ala Gly Asn Ser  Val Cys His Asn His  His Asn His 
    1715                 1720                 1725             


Asn Ser  Ile Gly Lys Gln Val  Pro Thr Ser Thr Asn  Ala Asn Leu 
    1730                 1735                 1740             


Asn Asn  Ala Asn Met Ser Lys  Ala Ala His Gly Lys  Arg Pro Ser 
    1745                 1750                 1755             


Ile Gly  Asn Leu Glu His Val  Ser Glu Asn Gly His  His Ser Ser 
    1760                 1765                 1770             


His Lys  His Asp Arg Glu Pro  Gln Arg Arg Ser Ser  Val Lys Arg 
    1775                 1780                 1785             


Ser Asp  Ser Gly Asp Glu Gln  Leu Pro Thr Ile Cys  Arg Glu Asp 
    1790                 1795                 1800             


Pro Glu  Ile His Gly Tyr Phe  Arg Asp Pro His Cys  Leu Gly Glu 
    1805                 1810                 1815             


Gln Glu  Tyr Phe Ser Ser Glu  Glu Cys Tyr Glu Asp  Asp Ser Ser 
    1820                 1825                 1830             


Pro Thr  Trp Ser Arg Gln Asn  Tyr Gly Tyr Tyr Ser  Arg Tyr Pro 
    1835                 1840                 1845             


Gly Arg  Asn Ile Asp Ser Glu  Arg Pro Arg Gly Tyr  His His Pro 
    1850                 1855                 1860             


Gln Gly  Phe Leu Glu Asp Asp  Asp Ser Pro Val Cys  Tyr Asp Ser 
    1865                 1870                 1875             


Arg Arg  Ser Pro Arg Arg Arg  Leu Leu Pro Pro Thr  Pro Ala Ser 
    1880                 1885                 1890             


His Arg  Arg Ser Ser Phe Asn  Phe Glu Cys Leu Arg  Arg Gln Ser 
    1895                 1900                 1905             


Ser Gln  Glu Glu Val Pro Ser  Ser Pro Ile Phe Pro  His Arg Thr 
    1910                 1915                 1920             


Ala Leu  Pro Leu His Leu Met  Gln Gln Gln Ile Met  Ala Val Ala 
    1925                 1930                 1935             


Gly Leu  Asp Ser Ser Lys Ala  Gln Lys Tyr Ser Pro  Ser His Ser 
    1940                 1945                 1950             


Thr Arg  Ser Trp Ala Thr Pro  Pro Ala Thr Pro Pro  Tyr Arg Asp 
    1955                 1960                 1965             


Trp Thr  Pro Cys Tyr Thr Pro  Leu Ile Gln Val Glu  Gln Ser Glu 
    1970                 1975                 1980             


Ala Leu  Asp Gln Val Asn Gly  Ser Leu Pro Ser Leu  His Arg Ser 
    1985                 1990                 1995             


Ser Trp  Tyr Thr Asp Glu Pro  Asp Ile Ser Tyr Arg  Thr Phe Thr 
    2000                 2005                 2010             


Pro Ala  Ser Leu Thr Val Pro  Ser Ser Phe Arg Asn  Lys Asn Ser 
    2015                 2020                 2025             


Asp Lys  Gln Arg Ser Ala Asp  Ser Leu Val Glu Ala  Val Leu Ile 
    2030                 2035                 2040             


Ser Glu  Gly Leu Gly Arg Tyr  Ala Arg Asp Pro Lys  Phe Val Ser 
    2045                 2050                 2055             


Ala Thr  Lys His Glu Ile Ala  Asp Ala Cys Asp Leu  Thr Ile Asp 
    2060                 2065                 2070             


Glu Met  Glu Ser Ala Ala Ser  Thr Leu Leu Asn Gly  Asn Val Arg 
    2075                 2080                 2085             


Pro Arg  Ala Asn Gly Asp Val  Gly Pro Leu Ser His  Arg Gln Asp 
    2090                 2095                 2100             


Tyr Glu  Leu Gln Asp Phe Gly  Pro Gly Tyr Ser Asp  Glu Glu Pro 
    2105                 2110                 2115             


Asp Pro  Gly Arg Asp Glu Glu  Asp Leu Ala Asp Glu  Met Ile Cys 
    2120                 2125                 2130             


Ile Thr  Thr Leu 
    2135         


<210>  1378
<211>  2161
<212>  PRT
<213>  Homo sapiens

<400>  1378

Met Met Met Met Met Met Met Lys Lys Met Gln His Gln Arg Gln Gln 
1               5                   10                  15      


Gln Ala Asp His Ala Asn Glu Ala Asn Tyr Ala Arg Gly Thr Arg Leu 
            20                  25                  30          


Pro Leu Ser Gly Glu Gly Pro Thr Ser Gln Pro Asn Ser Ser Lys Gln 
        35                  40                  45              


Thr Val Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys 
    50                  55                  60                  


Ala Ala Gln Thr Met Ser Thr Ser Ala Pro Pro Pro Val Gly Ser Leu 
65                  70                  75                  80  


Ser Gln Arg Lys Arg Gln Gln Tyr Ala Lys Ser Lys Lys Gln Gly Asn 
                85                  90                  95      


Ser Ser Asn Ser Arg Pro Ala Arg Ala Leu Phe Cys Leu Ser Leu Asn 
            100                 105                 110         


Asn Pro Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe 
        115                 120                 125             


Asp Ile Phe Ile Leu Leu Ala Ile Phe Ala Asn Cys Val Ala Leu Ala 
    130                 135                 140                 


Ile Tyr Ile Pro Phe Pro Glu Asp Asp Ser Asn Ser Thr Asn His Asn 
145                 150                 155                 160 


Leu Glu Lys Val Glu Tyr Ala Phe Leu Ile Ile Phe Thr Val Glu Thr 
                165                 170                 175     


Phe Leu Lys Ile Ile Ala Tyr Gly Leu Leu Leu His Pro Asn Ala Tyr 
            180                 185                 190         


Val Arg Asn Gly Trp Asn Leu Leu Asp Phe Val Ile Val Ile Val Gly 
        195                 200                 205             


Leu Phe Ser Val Ile Leu Glu Gln Leu Thr Lys Glu Thr Glu Gly Gly 
    210                 215                 220                 


Asn His Ser Ser Gly Lys Ser Gly Gly Phe Asp Val Lys Ala Leu Arg 
225                 230                 235                 240 


Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser 
                245                 250                 255     


Leu Gln Val Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu 
            260                 265                 270         


His Ile Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile 
        275                 280                 285             


Gly Leu Glu Leu Phe Ile Gly Lys Met His Lys Thr Cys Phe Phe Ala 
    290                 295                 300                 


Asp Ser Asp Ile Val Ala Glu Glu Asp Pro Ala Pro Cys Ala Phe Ser 
305                 310                 315                 320 


Gly Asn Gly Arg Gln Cys Thr Ala Asn Gly Thr Glu Cys Arg Ser Gly 
                325                 330                 335     


Trp Val Gly Pro Asn Gly Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe 
            340                 345                 350         


Ala Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp 
        355                 360                 365             


Val Leu Tyr Trp Met Asn Asp Ala Met Gly Phe Glu Leu Pro Trp Val 
    370                 375                 380                 


Tyr Phe Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu 
385                 390                 395                 400 


Val Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala 
                405                 410                 415     


Lys Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu 
            420                 425                 430         


Glu Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile 
        435                 440                 445             


Asp Pro Glu Asn Glu Glu Glu Gly Gly Glu Glu Gly Lys Arg Asn Thr 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ser 
465                 470                 475                 480 


Gly Glu Gly Glu Asn Arg Gly Cys Cys Gly Ser Leu Cys Gln Ala Ile 
                485                 490                 495     


Ser Lys Ser Lys Leu Ser Arg Arg Trp Arg Arg Trp Asn Arg Phe Asn 
            500                 505                 510         


Arg Arg Arg Cys Arg Ala Ala Val Lys Ser Val Thr Phe Tyr Trp Leu 
        515                 520                 525             


Val Ile Val Leu Val Phe Leu Asn Thr Leu Thr Ile Ser Ser Glu His 
    530                 535                 540                 


Tyr Asn Gln Pro Asp Trp Leu Thr Gln Ile Gln Asp Ile Ala Asn Lys 
545                 550                 555                 560 


Val Leu Leu Ala Leu Phe Thr Cys Glu Met Leu Val Lys Met Tyr Ser 
                565                 570                 575     


Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp Cys 
            580                 585                 590         


Phe Val Val Cys Gly Gly Ile Thr Glu Thr Ile Leu Val Glu Leu Glu 
        595                 600                 605             


Ile Met Ser Pro Leu Gly Ile Ser Val Phe Arg Cys Val Arg Leu Leu 
    610                 615                 620                 


Arg Ile Phe Lys Val Thr Arg His Trp Thr Ser Leu Ser Asn Leu Val 
625                 630                 635                 640 


Ala Ser Leu Leu Asn Ser Met Lys Ser Ile Ala Ser Leu Leu Leu Leu 
                645                 650                 655     


Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu Phe 
            660                 665                 670         


Gly Gly Lys Phe Asn Phe Asp Glu Thr Gln Thr Lys Arg Ser Thr Phe 
        675                 680                 685             


Asp Asn Phe Pro Gln Ala Leu Leu Thr Val Phe Gln Ile Leu Thr Gly 
    690                 695                 700                 


Glu Asp Trp Asn Ala Val Met Tyr Asp Gly Ile Met Ala Tyr Gly Gly 
705                 710                 715                 720 


Pro Ser Ser Ser Gly Met Ile Val Cys Ile Tyr Phe Ile Ile Leu Phe 
                725                 730                 735     


Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala Val 
            740                 745                 750         


Asp Asn Leu Ala Asp Ala Glu Ser Leu Asn Thr Ala Gln Lys Glu Glu 
        755                 760                 765             


Ala Glu Glu Lys Glu Arg Lys Lys Ile Ala Arg Lys Glu Ser Leu Glu 
    770                 775                 780                 


Asn Lys Lys Asn Asn Lys Pro Glu Val Asn Gln Ile Ala Asn Ser Asp 
785                 790                 795                 800 


Asn Lys Val Thr Ile Asp Asp Tyr Arg Glu Glu Asp Glu Asp Lys Asp 
                805                 810                 815     


Pro Tyr Pro Pro Cys Asp Val Pro Val Gly Glu Glu Glu Glu Glu Glu 
            820                 825                 830         


Glu Glu Asp Glu Pro Glu Val Pro Ala Gly Pro Arg Pro Arg Arg Ile 
        835                 840                 845             


Ser Glu Leu Asn Met Lys Glu Lys Ile Ala Pro Ile Pro Glu Gly Ser 
    850                 855                 860                 


Ala Phe Phe Ile Leu Ser Lys Thr Asn Pro Ile Arg Val Gly Cys His 
865                 870                 875                 880 


Lys Leu Ile Asn His His Ile Phe Thr Asn Leu Ile Leu Val Phe Ile 
                885                 890                 895     


Met Leu Ser Ser Ala Ala Leu Ala Ala Glu Asp Pro Ile Arg Ser His 
            900                 905                 910         


Ser Phe Arg Asn Thr Ile Leu Gly Tyr Phe Asp Tyr Ala Phe Thr Ala 
        915                 920                 925             


Ile Phe Thr Val Glu Ile Leu Leu Lys Met Thr Thr Phe Gly Ala Phe 
    930                 935                 940                 


Leu His Lys Gly Ala Phe Cys Arg Asn Tyr Phe Asn Leu Leu Asp Met 
945                 950                 955                 960 


Leu Val Val Gly Val Ser Leu Val Ser Phe Gly Ile Gln Ser Ser Ala 
                965                 970                 975     


Ile Ser Val Val Lys Ile Leu Arg Val Leu Arg Val Leu Arg Pro Leu 
            980                 985                 990         


Arg Ala Ile Asn Arg Ala Lys Gly  Leu Lys His Val Val  Gln Cys Val 
        995                 1000                 1005             


Phe Val  Ala Ile Arg Thr Ile  Gly Asn Ile Met Ile  Val Thr Thr 
    1010                 1015                 1020             


Leu Leu  Gln Phe Met Phe Ala  Cys Ile Gly Val Gln  Leu Phe Lys 
    1025                 1030                 1035             


Gly Lys  Phe Tyr Arg Cys Thr  Asp Glu Ala Lys Ser  Asn Pro Glu 
    1040                 1045                 1050             


Glu Cys  Arg Gly Leu Phe Ile  Leu Tyr Lys Asp Gly  Asp Val Asp 
    1055                 1060                 1065             


Ser Pro  Val Val Arg Glu Arg  Ile Trp Gln Asn Ser  Asp Phe Asn 
    1070                 1075                 1080             


Phe Asp  Asn Val Leu Ser Ala  Met Met Ala Leu Phe  Thr Val Ser 
    1085                 1090                 1095             


Thr Phe  Glu Gly Trp Pro Ala  Leu Leu Tyr Lys Ala  Ile Asp Ser 
    1100                 1105                 1110             


Asn Gly  Glu Asn Ile Gly Pro  Ile Tyr Asn His Arg  Val Glu Ile 
    1115                 1120                 1125             


Ser Ile  Phe Phe Ile Ile Tyr  Ile Ile Ile Val Ala  Phe Phe Met 
    1130                 1135                 1140             


Met Asn  Ile Phe Val Gly Phe  Val Ile Val Thr Phe  Gln Glu Gln 
    1145                 1150                 1155             


Gly Glu  Lys Glu Tyr Lys Asn  Cys Glu Leu Asp Lys  Asn Gln Arg 
    1160                 1165                 1170             


Gln Cys  Val Glu Tyr Ala Leu  Lys Ala Arg Pro Leu  Arg Arg Tyr 
    1175                 1180                 1185             


Ile Pro  Lys Asn Pro Tyr Gln  Tyr Lys Phe Trp Tyr  Val Val Asn 
    1190                 1195                 1200             


Ser Ser  Pro Phe Glu Tyr Met  Met Phe Val Leu Ile  Met Leu Asn 
    1205                 1210                 1215             


Thr Leu  Cys Leu Ala Met Gln  His Tyr Glu Gln Ser  Lys Met Phe 
    1220                 1225                 1230             


Asn Asp  Ala Met Asp Ile Leu  Asn Met Val Phe Thr  Gly Val Phe 
    1235                 1240                 1245             


Thr Val  Glu Met Val Leu Lys  Val Ile Ala Phe Lys  Pro Lys Gly 
    1250                 1255                 1260             


Tyr Phe  Ser Asp Ala Trp Asn  Thr Phe Asp Ser Leu  Ile Val Ile 
    1265                 1270                 1275             


Gly Ser  Ile Ile Asp Val Ala  Leu Ser Glu Ala Asp  Pro Thr Glu 
    1280                 1285                 1290             


Ser Glu  Asn Val Pro Val Pro  Thr Ala Thr Pro Gly  Asn Ser Glu 
    1295                 1300                 1305             


Glu Ser  Asn Arg Ile Ser Ile  Thr Phe Phe Arg Leu  Phe Arg Val 
    1310                 1315                 1320             


Met Arg  Leu Val Lys Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Thr 
    1325                 1330                 1335             


Leu Leu  Trp Thr Phe Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val 
    1340                 1345                 1350             


Ala Leu  Leu Ile Ala Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly 
    1355                 1360                 1365             


Met Gln  Met Phe Gly Lys Val  Ala Met Arg Asp Asn  Asn Gln Ile 
    1370                 1375                 1380             


Asn Arg  Asn Asn Asn Phe Gln  Thr Phe Pro Gln Ala  Val Leu Leu 
    1385                 1390                 1395             


Leu Phe  Arg Cys Ala Thr Gly  Glu Ala Trp Gln Glu  Ile Met Leu 
    1400                 1405                 1410             


Ala Cys  Leu Pro Gly Lys Leu  Cys Asp Pro Glu Ser  Asp Tyr Asn 
    1415                 1420                 1425             


Pro Gly  Glu Glu Tyr Thr Cys  Gly Ser Asn Phe Ala  Ile Val Tyr 
    1430                 1435                 1440             


Phe Ile  Ser Phe Tyr Met Leu  Cys Ala Phe Leu Ile  Ile Asn Leu 
    1445                 1450                 1455             


Phe Val  Ala Val Ile Met Asp  Asn Phe Asp Tyr Leu  Thr Arg Asp 
    1460                 1465                 1470             


Trp Ser  Ile Leu Gly Pro His  His Leu Asp Glu Phe  Lys Arg Ile 
    1475                 1480                 1485             


Trp Ser  Glu Tyr Asp Pro Glu  Ala Lys Gly Arg Ile  Lys His Leu 
    1490                 1495                 1500             


Asp Val  Val Thr Leu Leu Arg  Arg Ile Gln Pro Pro  Leu Gly Phe 
    1505                 1510                 1515             


Gly Lys  Leu Cys Pro His Arg  Val Ala Cys Lys Arg  Leu Val Ala 
    1520                 1525                 1530             


Met Asn  Met Pro Leu Asn Ser  Asp Gly Thr Val Met  Phe Asn Ala 
    1535                 1540                 1545             


Thr Leu  Phe Ala Leu Val Arg  Thr Ala Leu Lys Ile  Lys Thr Glu 
    1550                 1555                 1560             


Gly Asn  Leu Glu Gln Ala Asn  Glu Glu Leu Arg Ala  Val Ile Lys 
    1565                 1570                 1575             


Lys Ile  Trp Lys Lys Thr Ser  Met Lys Leu Leu Asp  Gln Val Val 
    1580                 1585                 1590             


Pro Pro  Ala Gly Asp Asp Glu  Val Thr Val Gly Lys  Phe Tyr Ala 
    1595                 1600                 1605             


Thr Phe  Leu Ile Gln Asp Tyr  Phe Arg Lys Phe Lys  Lys Arg Lys 
    1610                 1615                 1620             


Glu Gln  Gly Leu Val Gly Lys  Tyr Pro Ala Lys Asn  Thr Thr Ile 
    1625                 1630                 1635             


Ala Leu  Gln Ala Gly Leu Arg  Thr Leu His Asp Ile  Gly Pro Glu 
    1640                 1645                 1650             


Ile Arg  Arg Ala Ile Ser Cys  Asp Leu Gln Asp Asp  Glu Pro Glu 
    1655                 1660                 1665             


Glu Thr  Lys Arg Glu Glu Glu  Asp Asp Val Phe Lys  Arg Asn Gly 
    1670                 1675                 1680             


Ala Leu  Leu Gly Asn His Val  Asn His Val Asn Ser  Asp Arg Arg 
    1685                 1690                 1695             


Asp Ser  Leu Gln Gln Thr Asn  Thr Thr His Arg Pro  Leu His Val 
    1700                 1705                 1710             


Gln Arg  Pro Ser Ile Pro Pro  Ala Ser Asp Thr Glu  Lys Pro Leu 
    1715                 1720                 1725             


Phe Pro  Pro Ala Gly Asn Ser  Val Cys His Asn His  His Asn His 
    1730                 1735                 1740             


Asn Ser  Ile Gly Lys Gln Val  Pro Thr Ser Thr Asn  Ala Asn Leu 
    1745                 1750                 1755             


Asn Asn  Ala Asn Met Ser Lys  Ala Ala His Gly Lys  Arg Pro Ser 
    1760                 1765                 1770             


Ile Gly  Asn Leu Glu His Val  Ser Glu Asn Gly His  His Ser Ser 
    1775                 1780                 1785             


His Lys  His Asp Arg Glu Pro  Gln Arg Arg Ser Ser  Val Lys Arg 
    1790                 1795                 1800             


Thr Arg  Tyr Tyr Glu Thr Tyr  Ile Arg Ser Asp Ser  Gly Asp Glu 
    1805                 1810                 1815             


Gln Leu  Pro Thr Ile Cys Arg  Glu Asp Pro Glu Ile  His Gly Tyr 
    1820                 1825                 1830             


Phe Arg  Asp Pro His Cys Leu  Gly Glu Gln Glu Tyr  Phe Ser Ser 
    1835                 1840                 1845             


Glu Glu  Cys Tyr Glu Asp Asp  Ser Ser Pro Thr Trp  Ser Arg Gln 
    1850                 1855                 1860             


Asn Tyr  Gly Tyr Tyr Ser Arg  Tyr Pro Gly Arg Asn  Ile Asp Ser 
    1865                 1870                 1875             


Glu Arg  Pro Arg Gly Tyr His  His Pro Gln Gly Phe  Leu Glu Asp 
    1880                 1885                 1890             


Asp Asp  Ser Pro Val Cys Tyr  Asp Ser Arg Arg Ser  Pro Arg Arg 
    1895                 1900                 1905             


Arg Leu  Leu Pro Pro Thr Pro  Ala Ser His Arg Arg  Ser Ser Phe 
    1910                 1915                 1920             


Asn Phe  Glu Cys Leu Arg Arg  Gln Ser Ser Gln Glu  Glu Val Pro 
    1925                 1930                 1935             


Ser Ser  Pro Ile Phe Pro His  Arg Thr Ala Leu Pro  Leu His Leu 
    1940                 1945                 1950             


Met Gln  Gln Gln Ile Met Ala  Val Ala Gly Leu Asp  Ser Ser Lys 
    1955                 1960                 1965             


Ala Gln  Lys Tyr Ser Pro Ser  His Ser Thr Arg Ser  Trp Ala Thr 
    1970                 1975                 1980             


Pro Pro  Ala Thr Pro Pro Tyr  Arg Asp Trp Thr Pro  Cys Tyr Thr 
    1985                 1990                 1995             


Pro Leu  Ile Gln Val Glu Gln  Ser Glu Ala Leu Asp  Gln Val Asn 
    2000                 2005                 2010             


Gly Ser  Leu Pro Ser Leu His  Arg Ser Ser Trp Tyr  Thr Asp Glu 
    2015                 2020                 2025             


Pro Asp  Ile Ser Tyr Arg Thr  Phe Thr Pro Ala Ser  Leu Thr Val 
    2030                 2035                 2040             


Pro Ser  Ser Phe Arg Asn Lys  Asn Ser Asp Lys Gln  Arg Ser Ala 
    2045                 2050                 2055             


Asp Ser  Leu Val Glu Ala Val  Leu Ile Ser Glu Gly  Leu Gly Arg 
    2060                 2065                 2070             


Tyr Ala  Arg Asp Pro Lys Phe  Val Ser Ala Thr Lys  His Glu Ile 
    2075                 2080                 2085             


Ala Asp  Ala Cys Asp Leu Thr  Ile Asp Glu Met Glu  Ser Ala Ala 
    2090                 2095                 2100             


Ser Thr  Leu Leu Asn Gly Asn  Val Arg Pro Arg Ala  Asn Gly Asp 
    2105                 2110                 2115             


Val Gly  Pro Leu Ser His Arg  Gln Asp Tyr Glu Leu  Gln Asp Phe 
    2120                 2125                 2130             


Gly Pro  Gly Tyr Ser Asp Glu  Glu Pro Asp Pro Gly  Arg Asp Glu 
    2135                 2140                 2145             


Glu Asp  Leu Ala Asp Glu Met  Ile Cys Ile Thr Thr  Leu 
    2150                 2155                 2160     


<210>  1379
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  1379

Met Arg Pro Gln Ile Leu Leu Leu Leu Ala Leu Leu Thr Leu Gly Leu 
1               5                   10                  15      


Ala Ala Gln His Gln Asp Lys Val Pro Cys Lys Met Val Asp Lys Lys 
            20                  25                  30          


Val Ser Cys Gln Val Leu Gly Leu Leu Gln Val Pro Ser Val Leu Pro 
        35                  40                  45              


Pro Asp Thr Glu Thr Leu Asp Leu Ser Gly Asn Gln Leu Arg Ser Ile 
    50                  55                  60                  


Leu Ala Ser Pro Leu Gly Phe Tyr Thr Ala Leu Arg His Leu Asp Leu 
65                  70                  75                  80  


Ser Thr Asn Glu Ile Ser Phe Leu Gln Pro Gly Ala Phe Gln Ala Leu 
                85                  90                  95      


Thr His Leu Glu His Leu Ser Leu Ala His Asn Arg Leu Ala Met Ala 
            100                 105                 110         


Thr Ala Leu Ser Ala Gly Gly Leu Gly Pro Leu Pro Arg Val Thr Ser 
        115                 120                 125             


Leu Asp Leu Ser Gly Asn Ser Leu Tyr Ser Gly Leu Leu Glu Arg Leu 
    130                 135                 140                 


Leu Gly Glu Ala Pro Ser Leu His Thr Leu Ser Leu Ala Glu Asn Ser 
145                 150                 155                 160 


Leu Thr Arg Leu Thr Arg His Thr Phe Arg Asp Met Pro Ala Leu Glu 
                165                 170                 175     


Gln Leu Asp Leu His Ser Asn Val Leu Met Asp Ile Glu Asp Gly Ala 
            180                 185                 190         


Phe Glu Gly Leu Pro Arg Leu Thr His Leu Asn Leu Ser Arg Asn Ser 
        195                 200                 205             


Leu Thr Cys Ile Ser Asp Phe Ser Leu Gln Gln Leu Arg Val Leu Asp 
    210                 215                 220                 


Leu Ser Cys Asn Ser Ile Glu Ala Phe Gln Thr Ala Ser Gln Pro Gln 
225                 230                 235                 240 


Ala Glu Phe Gln Leu Thr Trp Leu Asp Leu Arg Glu Asn Lys Leu Leu 
                245                 250                 255     


His Phe Pro Asp Leu Ala Ala Leu Pro Arg Leu Ile Tyr Leu Asn Leu 
            260                 265                 270         


Ser Asn Asn Leu Ile Arg Leu Pro Thr Gly Pro Pro Gln Asp Ser Lys 
        275                 280                 285             


Gly Ile His Ala Pro Ser Glu Gly Trp Ser Ala Leu Pro Leu Ser Ala 
    290                 295                 300                 


Pro Ser Gly Asn Ala Ser Gly Arg Pro Leu Ser Gln Leu Leu Asn Leu 
305                 310                 315                 320 


Asp Leu Ser Tyr Asn Glu Ile Glu Leu Ile Pro Asp Ser Phe Leu Glu 
                325                 330                 335     


His Leu Thr Ser Leu Cys Phe Leu Asn Leu Ser Arg Asn Cys Leu Arg 
            340                 345                 350         


Thr Phe Glu Ala Arg Arg Leu Gly Ser Leu Pro Cys Leu Met Leu Leu 
        355                 360                 365             


Asp Leu Ser His Asn Ala Leu Glu Thr Leu Glu Leu Gly Ala Arg Ala 
    370                 375                 380                 


Leu Gly Ser Leu Arg Thr Leu Leu Leu Gln Gly Asn Ala Leu Arg Asp 
385                 390                 395                 400 


Leu Pro Pro Tyr Thr Phe Ala Asn Leu Ala Ser Leu Gln Arg Leu Asn 
                405                 410                 415     


Leu Gln Gly Asn Arg Val Ser Pro Cys Gly Gly Pro Asp Glu Pro Gly 
            420                 425                 430         


Pro Ser Gly Cys Val Ala Phe Ser Gly Ile Thr Ser Leu Arg Ser Leu 
        435                 440                 445             


Ser Leu Val Asp Asn Glu Ile Glu Leu Leu Arg Ala Gly Ala Phe Leu 
    450                 455                 460                 


His Thr Pro Leu Thr Glu Leu Asp Leu Ser Ser Asn Pro Gly Leu Glu 
465                 470                 475                 480 


Val Ala Thr Gly Ala Leu Gly Gly Leu Glu Ala Ser Leu Glu Val Leu 
                485                 490                 495     


Ala Leu Gln Gly Asn Gly Leu Met Val Leu Gln Val Asp Leu Pro Cys 
            500                 505                 510         


Phe Ile Cys Leu Lys Arg Leu Asn Leu Ala Glu Asn Arg Leu Ser His 
        515                 520                 525             


Leu Pro Ala Trp Thr Gln Ala Val Ser Leu Glu Val Leu Asp Leu Arg 
    530                 535                 540                 


Asn Asn Ser Phe Ser Leu Leu Pro Gly Ser Ala Met Gly Gly Leu Glu 
545                 550                 555                 560 


Thr Ser Leu Arg Arg Leu Tyr Leu Gln Gly Asn Pro Leu Ser Cys Cys 
                565                 570                 575     


Gly Asn Gly Trp Leu Ala Ala Gln Leu His Gln Gly Arg Val Asp Val 
            580                 585                 590         


Asp Ala Thr Gln Asp Leu Ile Cys Arg Phe Ser Ser Gln Glu Glu Val 
        595                 600                 605             


Ser Leu Ser His Val Arg Pro Glu Asp Cys Glu Lys Gly Gly Leu Lys 
    610                 615                 620                 


Asn Ile Asn Leu Ile Ile Ile Leu Thr Phe Ile Leu Val Ser Ala Ile 
625                 630                 635                 640 


Leu Leu Thr Thr Leu Ala Ala Cys Cys Cys Val Arg Arg Gln Lys Phe 
                645                 650                 655     


Asn Gln Gln Tyr Lys Ala 
            660         


<210>  1380
<211>  1394
<212>  PRT
<213>  Homo sapiens

<400>  1380

Met Ala Arg Arg His Glu Arg Val Thr Arg Arg Met Trp Thr Trp Ala 
1               5                   10                  15      


Pro Gly Leu Leu Met Met Thr Val Val Phe Trp Gly His Gln Gly Asn 
            20                  25                  30          


Gly Gln Gly Gln Gly Ser Arg Leu Arg Gln Glu Asp Phe Pro Pro Arg 
        35                  40                  45              


Ile Val Glu His Pro Ser Asp Val Ile Val Ser Lys Gly Glu Pro Thr 
    50                  55                  60                  


Thr Leu Asn Cys Lys Ala Glu Gly Arg Pro Thr Pro Thr Ile Glu Trp 
65                  70                  75                  80  


Tyr Lys Asp Gly Glu Arg Val Glu Thr Asp Lys Asp Asp Pro Arg Ser 
                85                  90                  95      


His Arg Met Leu Leu Pro Ser Gly Ser Leu Phe Phe Leu Arg Ile Val 
            100                 105                 110         


His Gly Arg Arg Ser Lys Pro Asp Glu Gly Ser Tyr Val Cys Val Ala 
        115                 120                 125             


Arg Asn Tyr Leu Gly Glu Ala Val Ser Arg Asn Ala Ser Leu Glu Val 
    130                 135                 140                 


Ala Leu Leu Arg Asp Asp Phe Arg Gln Asn Pro Thr Asp Val Val Val 
145                 150                 155                 160 


Ala Ala Gly Glu Pro Ala Ile Leu Glu Cys Gln Pro Pro Arg Gly His 
                165                 170                 175     


Pro Glu Pro Thr Ile Tyr Trp Lys Lys Asp Lys Val Arg Ile Asp Asp 
            180                 185                 190         


Lys Glu Glu Arg Ile Ser Ile Arg Gly Gly Lys Leu Met Ile Ser Asn 
        195                 200                 205             


Thr Arg Lys Ser Asp Ala Gly Met Tyr Thr Cys Val Gly Thr Asn Met 
    210                 215                 220                 


Val Gly Glu Arg Asp Ser Asp Pro Ala Glu Leu Thr Val Phe Glu Arg 
225                 230                 235                 240 


Pro Thr Phe Leu Arg Arg Pro Ile Asn Gln Val Val Leu Glu Glu Glu 
                245                 250                 255     


Ala Val Glu Phe Arg Cys Gln Val Gln Gly Asp Pro Gln Pro Thr Val 
            260                 265                 270         


Arg Trp Lys Lys Asp Asp Ala Asp Leu Pro Arg Gly Arg Tyr Asp Ile 
        275                 280                 285             


Lys Asp Asp Tyr Thr Leu Arg Ile Lys Lys Thr Met Ser Thr Asp Glu 
    290                 295                 300                 


Gly Thr Tyr Met Cys Ile Ala Glu Asn Arg Val Gly Lys Met Glu Ala 
305                 310                 315                 320 


Ser Ala Thr Leu Thr Val Arg Ala Pro Pro Gln Phe Val Val Arg Pro 
                325                 330                 335     


Arg Asp Gln Ile Val Ala Gln Gly Arg Thr Val Thr Phe Pro Cys Glu 
            340                 345                 350         


Thr Lys Gly Asn Pro Gln Pro Ala Val Phe Trp Gln Lys Glu Gly Ser 
        355                 360                 365             


Gln Asn Leu Leu Phe Pro Asn Gln Pro Gln Gln Pro Asn Ser Arg Cys 
    370                 375                 380                 


Ser Val Ser Pro Thr Gly Asp Leu Thr Ile Thr Asn Ile Gln Arg Ser 
385                 390                 395                 400 


Asp Ala Gly Tyr Tyr Ile Cys Gln Ala Leu Thr Val Ala Gly Ser Ile 
                405                 410                 415     


Leu Ala Lys Ala Gln Leu Glu Val Thr Asp Val Leu Thr Asp Arg Pro 
            420                 425                 430         


Pro Pro Ile Ile Leu Gln Gly Pro Ala Asn Gln Thr Leu Ala Val Asp 
        435                 440                 445             


Gly Thr Ala Leu Leu Lys Cys Lys Ala Thr Gly Asp Pro Leu Pro Val 
    450                 455                 460                 


Ile Ser Trp Leu Lys Glu Gly Phe Thr Phe Pro Gly Arg Asp Pro Arg 
465                 470                 475                 480 


Ala Thr Ile Gln Glu Gln Gly Thr Leu Gln Ile Lys Asn Leu Arg Ile 
                485                 490                 495     


Ser Asp Thr Gly Thr Tyr Thr Cys Val Ala Thr Ser Ser Ser Gly Glu 
            500                 505                 510         


Thr Ser Trp Ser Ala Val Leu Asp Val Thr Glu Ser Gly Ala Thr Ile 
        515                 520                 525             


Ser Lys Asn Tyr Asp Leu Ser Asp Leu Pro Gly Pro Pro Ser Lys Pro 
    530                 535                 540                 


Gln Val Thr Asp Val Thr Lys Asn Ser Val Thr Leu Ser Trp Gln Pro 
545                 550                 555                 560 


Gly Thr Pro Gly Thr Leu Pro Ala Ser Ala Tyr Ile Ile Glu Ala Phe 
                565                 570                 575     


Ser Gln Ser Val Ser Asn Ser Trp Gln Thr Val Ala Asn His Val Lys 
            580                 585                 590         


Thr Thr Leu Tyr Thr Val Arg Gly Leu Arg Pro Asn Thr Ile Tyr Leu 
        595                 600                 605             


Phe Met Val Arg Ala Ile Asn Pro Gln Gly Leu Ser Asp Pro Ser Pro 
    610                 615                 620                 


Met Ser Asp Pro Val Arg Thr Gln Asp Ile Ser Pro Pro Ala Gln Gly 
625                 630                 635                 640 


Val Asp His Arg Gln Val Gln Lys Glu Leu Gly Asp Val Leu Val Arg 
                645                 650                 655     


Leu His Asn Pro Val Val Leu Thr Pro Thr Thr Val Gln Val Thr Trp 
            660                 665                 670         


Thr Val Asp Arg Gln Pro Gln Phe Ile Gln Gly Tyr Arg Val Met Tyr 
        675                 680                 685             


Arg Gln Thr Ser Gly Leu Gln Ala Thr Ser Ser Trp Gln Asn Leu Asp 
    690                 695                 700                 


Ala Lys Val Pro Thr Glu Arg Ser Ala Val Leu Val Asn Leu Lys Lys 
705                 710                 715                 720 


Gly Val Thr Tyr Glu Ile Lys Val Arg Pro Tyr Phe Asn Glu Phe Gln 
                725                 730                 735     


Gly Met Asp Ser Glu Ser Lys Thr Val Arg Thr Thr Glu Glu Ala Pro 
            740                 745                 750         


Ser Ala Pro Pro Gln Ser Val Thr Val Leu Thr Val Gly Ser Tyr Asn 
        755                 760                 765             


Ser Thr Ser Ile Ser Val Ser Trp Asp Pro Pro Pro Pro Asp His Gln 
    770                 775                 780                 


Asn Gly Ile Ile Gln Glu Tyr Lys Ile Trp Cys Leu Gly Asn Glu Thr 
785                 790                 795                 800 


Arg Phe His Ile Asn Lys Thr Val Asp Ala Ala Ile Arg Ser Val Ile 
                805                 810                 815     


Ile Gly Gly Leu Phe Pro Gly Ile Gln Tyr Arg Val Glu Val Ala Ala 
            820                 825                 830         


Ser Thr Ser Ala Gly Val Gly Val Lys Ser Glu Pro Gln Pro Ile Ile 
        835                 840                 845             


Ile Gly Arg Arg Asn Glu Val Val Ile Thr Glu Asn Asn Asn Ser Ile 
    850                 855                 860                 


Thr Glu Gln Ile Thr Asp Val Val Lys Gln Pro Ala Phe Ile Ala Gly 
865                 870                 875                 880 


Ile Gly Gly Ala Cys Trp Val Ile Leu Met Gly Phe Ser Ile Trp Leu 
                885                 890                 895     


Tyr Trp Arg Arg Lys Lys Arg Lys Gly Leu Ser Asn Tyr Ala Val Thr 
            900                 905                 910         


Phe Gln Arg Gly Asp Gly Gly Leu Met Ser Asn Gly Ser Arg Pro Gly 
        915                 920                 925             


Leu Leu Asn Ala Gly Asp Pro Ser Tyr Pro Trp Leu Ala Asp Ser Trp 
    930                 935                 940                 


Pro Ala Thr Ser Leu Pro Val Asn Asn Ser Asn Ser Gly Pro Asn Glu 
945                 950                 955                 960 


Ile Gly Asn Phe Gly Arg Gly Asp Val Leu Pro Pro Val Pro Gly Gln 
                965                 970                 975     


Gly Asp Lys Thr Ala Thr Met Leu Ser Asp Gly Ala Ile Tyr Ser Ser 
            980                 985                 990         


Ile Asp Phe Thr Thr Lys Thr Ser  Tyr Asn Ser Ser Ser  Gln Ile Thr 
        995                 1000                 1005             


Gln Ala  Thr Pro Tyr Ala Thr  Thr Gln Ile Leu His  Ser Asn Ser 
    1010                 1015                 1020             


Ile His  Glu Leu Ala Val Asp  Leu Pro Asp Pro Gln  Trp Lys Ser 
    1025                 1030                 1035             


Ser Ile  Gln Gln Lys Thr Asp  Leu Met Gly Phe Gly  Tyr Ser Leu 
    1040                 1045                 1050             


Pro Asp  Gln Asn Lys Gly Asn  Asn Gly Gly Lys Gly  Gly Lys Lys 
    1055                 1060                 1065             


Lys Lys  Asn Lys Asn Ser Ser  Lys Pro Gln Lys Asn  Asn Gly Ser 
    1070                 1075                 1080             


Thr Trp  Ala Asn Val Pro Leu  Pro Pro Pro Pro Val  Gln Pro Leu 
    1085                 1090                 1095             


Pro Gly  Thr Glu Leu Glu His  Tyr Ala Val Glu Gln  Gln Glu Asn 
    1100                 1105                 1110             


Gly Tyr  Asp Ser Asp Ser Trp  Cys Pro Pro Leu Pro  Val Gln Thr 
    1115                 1120                 1125             


Tyr Leu  His Gln Gly Leu Glu  Asp Glu Leu Glu Glu  Asp Asp Asp 
    1130                 1135                 1140             


Arg Val  Pro Thr Pro Pro Val  Arg Gly Val Ala Ser  Ser Pro Ala 
    1145                 1150                 1155             


Ile Ser  Phe Gly Gln Gln Ser  Thr Ala Thr Leu Thr  Pro Ser Pro 
    1160                 1165                 1170             


Arg Glu  Glu Met Gln Pro Met  Leu Gln Ala His Leu  Asp Glu Leu 
    1175                 1180                 1185             


Thr Arg  Ala Tyr Gln Phe Asp  Ile Ala Lys Gln Thr  Trp His Ile 
    1190                 1195                 1200             


Gln Ser  Asn Asn Gln Pro Pro  Gln Pro Pro Val Pro  Pro Leu Gly 
    1205                 1210                 1215             


Tyr Val  Ser Gly Ala Leu Ile  Ser Asp Leu Glu Thr  Asp Val Ala 
    1220                 1225                 1230             


Asp Asp  Asp Ala Asp Asp Glu  Glu Glu Ala Leu Glu  Ile Pro Arg 
    1235                 1240                 1245             


Pro Leu  Arg Ala Leu Asp Gln  Thr Pro Gly Ser Ser  Met Asp Asn 
    1250                 1255                 1260             


Leu Asp  Ser Ser Val Thr Gly  Lys Ala Phe Thr Ser  Ser Gln Arg 
    1265                 1270                 1275             


Pro Arg  Pro Thr Ser Pro Phe  Ser Thr Asp Ser Asn  Thr Ser Ala 
    1280                 1285                 1290             


Ala Leu  Ser Gln Ser Gln Arg  Pro Arg Pro Thr Lys  Lys His Lys 
    1295                 1300                 1305             


Gly Gly  Arg Met Asp Gln Gln  Pro Ala Leu Pro His  Arg Arg Glu 
    1310                 1315                 1320             


Gly Met  Thr Asp Glu Glu Ala  Leu Val Pro Tyr Ser  Lys Pro Ser 
    1325                 1330                 1335             


Phe Pro  Ser Pro Gly Gly His  Ser Ser Ser Gly Thr  Ala Ser Ser 
    1340                 1345                 1350             


Lys Gly  Ser Thr Gly Pro Arg  Lys Thr Glu Val Leu  Arg Ala Gly 
    1355                 1360                 1365             


His Gln  Arg Asn Ala Ser Asp  Leu Leu Asp Ile Gly  Tyr Met Gly 
    1370                 1375                 1380             


Ser Asn  Ser Gln Gly Gln Phe  Thr Gly Glu Leu 
    1385                 1390                 


<210>  1381
<211>  608
<212>  PRT
<213>  Homo sapiens

<400>  1381

Met Gly Arg Ile Gly Ile Ser Cys Leu Phe Pro Ala Ser Trp His Phe 
1               5                   10                  15      


Ser Ile Ser Pro Val Gly Cys Pro Arg Ile Leu Asn Thr Asn Leu Arg 
            20                  25                  30          


Gln Ile Met Val Ile Ser Val Leu Ala Ala Ala Val Ser Leu Leu Tyr 
        35                  40                  45              


Phe Ser Val Val Ile Ile Arg Asn Lys Tyr Gly Arg Leu Thr Arg Asp 
    50                  55                  60                  


Lys Lys Phe Gln Arg Tyr Leu Ala Arg Val Thr Asp Ile Glu Ala Thr 
65                  70                  75                  80  


Asp Thr Asn Asn Pro Asn Val Asn Tyr Gly Ile Val Val Asp Cys Gly 
                85                  90                  95      


Ser Ser Gly Ser Arg Val Phe Val Tyr Cys Trp Pro Arg His Asn Gly 
            100                 105                 110         


Asn Pro His Asp Leu Leu Asp Ile Arg Gln Met Arg Asp Lys Asn Arg 
        115                 120                 125             


Lys Pro Val Val Met Lys Ile Lys Pro Gly Ile Ser Glu Phe Ala Thr 
    130                 135                 140                 


Ser Pro Glu Lys Val Ser Asp Tyr Ile Ser Pro Leu Leu Asn Phe Ala 
145                 150                 155                 160 


Ala Glu His Val Pro Arg Ala Lys His Lys Glu Thr Pro Leu Tyr Ile 
                165                 170                 175     


Leu Cys Thr Ala Gly Met Arg Ile Leu Pro Glu Ser Gln Gln Lys Ala 
            180                 185                 190         


Ile Leu Glu Asp Leu Leu Thr Asp Ile Pro Val His Phe Asp Phe Leu 
        195                 200                 205             


Phe Ser Asp Ser His Ala Glu Val Ile Ser Gly Lys Gln Glu Gly Val 
    210                 215                 220                 


Tyr Ala Trp Ile Gly Ile Asn Phe Val Leu Gly Arg Phe Glu His Ile 
225                 230                 235                 240 


Glu Asp Asp Asp Glu Ala Val Val Glu Val Asn Ile Pro Gly Ser Glu 
                245                 250                 255     


Ser Ser Glu Ala Ile Val Arg Lys Arg Thr Ala Gly Ile Leu Asp Met 
            260                 265                 270         


Gly Gly Val Ser Thr Gln Ile Ala Tyr Glu Val Pro Lys Thr Glu Glu 
        275                 280                 285             


Val Ala Lys Asn Leu Leu Ala Glu Phe Asn Leu Gly Cys Asp Val His 
    290                 295                 300                 


Gln Thr Glu His Val Tyr Arg Val Tyr Val Ala Thr Phe Leu Gly Phe 
305                 310                 315                 320 


Gly Gly Asn Ala Ala Arg Gln Arg Tyr Glu Asp Arg Ile Phe Ala Asn 
                325                 330                 335     


Thr Ile Gln Lys Asn Arg Leu Leu Gly Lys Gln Thr Gly Leu Thr Pro 
            340                 345                 350         


Asp Met Pro Tyr Leu Asp Pro Cys Leu Pro Leu Asp Ile Lys Asp Glu 
        355                 360                 365             


Ile Gln Gln Asn Gly Gln Thr Ile Tyr Leu Arg Gly Thr Gly Asp Phe 
    370                 375                 380                 


Asp Leu Cys Arg Glu Thr Ile Gln Pro Phe Met Asn Lys Thr Asn Glu 
385                 390                 395                 400 


Thr Gln Thr Ser Leu Asn Gly Val Tyr Gln Pro Pro Ile His Phe Gln 
                405                 410                 415     


Asn Ser Glu Phe Tyr Gly Phe Ser Glu Phe Tyr Tyr Cys Thr Glu Asp 
            420                 425                 430         


Val Leu Arg Met Gly Gly Asp Tyr Asn Ala Ala Lys Phe Thr Lys Ala 
        435                 440                 445             


Ala Lys Asp Tyr Cys Ala Thr Lys Trp Ser Ile Leu Arg Glu Arg Phe 
    450                 455                 460                 


Asp Arg Gly Leu Tyr Ala Ser His Ala Asp Leu His Arg Leu Lys Tyr 
465                 470                 475                 480 


Gln Cys Phe Lys Ser Ala Trp Met Phe Glu Val Phe His Arg Gly Phe 
                485                 490                 495     


Ser Phe Pro Val Asn Tyr Lys Ser Leu Lys Thr Ala Leu Gln Val Tyr 
            500                 505                 510         


Asp Lys Glu Val Gln Trp Thr Leu Gly Ala Ile Leu Tyr Arg Thr Arg 
        515                 520                 525             


Phe Leu Pro Leu Arg Asp Ile Gln Gln Glu Ala Phe Arg Ala Ser His 
    530                 535                 540                 


Thr His Trp Arg Gly Val Ser Phe Val Tyr Asn His Tyr Leu Phe Ser 
545                 550                 555                 560 


Gly Cys Phe Leu Val Val Leu Leu Ala Ile Leu Leu Tyr Leu Leu Arg 
                565                 570                 575     


Leu Arg Arg Ile His Arg Arg Thr Pro Arg Ser Ser Ser Ala Ala Ala 
            580                 585                 590         


Leu Trp Met Glu Glu Gly Leu Pro Ala Gln Asn Ala Pro Gly Thr Leu 
        595                 600                 605             


<210>  1382
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  1382

Met Asp Lys Phe Arg Met Leu Phe Gln His Phe Gln Ser Ser Ser Glu 
1               5                   10                  15      


Ser Val Met Asn Gly Ile Cys Leu Leu Leu Ala Ala Val Thr Val Lys 
            20                  25                  30          


Leu Tyr Ser Ser Phe Asp Phe Asn Cys Pro Cys Leu Val His Tyr Asn 
        35                  40                  45              


Ala Leu Tyr Gly Leu Gly Leu Leu Leu Thr Pro Pro Leu Ala Leu Phe 
    50                  55                  60                  


Leu Cys Gly Leu Leu Ala Asn Arg Gln Ser Val Val Met Val Glu Glu 
65                  70                  75                  80  


Trp Arg Arg Pro Ala Gly His Arg Arg Lys Asp Pro Gly Ile Ile Arg 
                85                  90                  95      


Tyr Met Cys Ser Ser Val Leu Gln Arg Ala Leu Ala Ala Pro Leu Val 
            100                 105                 110         


Trp Ile Leu Leu Ala Leu Leu Asp Gly Lys Cys Phe Val Cys Ala Phe 
        115                 120                 125             


Ser Ser Ser Val Asp Pro Glu Lys Phe Leu Asp Phe Ala Asn Met Thr 
    130                 135                 140                 


Pro Ser Gln Val Gln Leu Phe Leu Ala Lys Val Pro Cys Lys Glu Asp 
145                 150                 155                 160 


Glu Leu Val Arg Asp Ser Pro Ala Arg Lys Ala Val Ser Arg Tyr Leu 
                165                 170                 175     


Arg Cys Leu Ser Gln Ala Ile Gly Trp Ser Val Thr Leu Leu Leu Ile 
            180                 185                 190         


Ile Ala Ala Phe Leu Ala Arg Cys Leu Arg Pro Cys Phe Asp Gln Thr 
        195                 200                 205             


Val Phe Leu Gln Arg Arg Tyr Trp Ser Asn Tyr Val Asp Leu Glu Gln 
    210                 215                 220                 


Lys Leu Phe Asp Glu Thr Cys Cys Glu His Ala Arg Asp Phe Ala His 
225                 230                 235                 240 


Arg Cys Val Leu His Phe Phe Ala Ser Met Arg Ser Glu Leu Gln Ala 
                245                 250                 255     


Arg Gly Leu Arg Arg Gly Asn Ala Gly Arg Arg Leu Glu Leu Pro Ala 
            260                 265                 270         


Val Pro Glu Pro Pro Glu Gly Leu Asp Ser Gly Ser Gly Lys Ala His 
        275                 280                 285             


Leu Arg Ala Ile Ser Ser Arg Glu Gln Val Asp Arg Leu Leu Ser Thr 
    290                 295                 300                 


Trp Tyr Ser Ser Lys Pro Pro Leu Asp Leu Ala Ala Ser Pro Gly Leu 
305                 310                 315                 320 


Cys Gly Gly Gly Leu Ser His Arg Ala Pro Thr Leu Ala Leu Gly Thr 
                325                 330                 335     


Arg Leu Ser Gln His Thr Asp Val 
            340                 


<210>  1383
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  1383

Met Glu Pro Ala Val Ser Glu Pro Met Arg Asp Gln Val Ala Arg Thr 
1               5                   10                  15      


His Leu Thr Glu Asp Thr Pro Lys Val Asn Ala Asp Ile Glu Lys Val 
            20                  25                  30          


Asn Gln Asn Gln Ala Lys Arg Cys Thr Val Ile Gly Gly Ser Gly Phe 
        35                  40                  45              


Leu Gly Gln His Met Val Glu Gln Leu Leu Ala Arg Gly Tyr Ala Val 
    50                  55                  60                  


Asn Val Phe Asp Ile Gln Gln Gly Phe Asp Asn Pro Gln Val Arg Phe 
65                  70                  75                  80  


Phe Leu Gly Asp Leu Cys Ser Arg Gln Asp Leu Tyr Pro Ala Leu Lys 
                85                  90                  95      


Gly Val Asn Thr Val Phe His Cys Ala Ser Pro Pro Pro Ser Ser Asn 
            100                 105                 110         


Asn Lys Glu Leu Phe Tyr Arg Val Asn Tyr Ile Gly Thr Lys Asn Val 
        115                 120                 125             


Ile Glu Thr Cys Lys Glu Ala Gly Val Gln Lys Leu Ile Leu Thr Ser 
    130                 135                 140                 


Ser Ala Ser Val Ile Phe Glu Gly Val Asp Ile Lys Asn Gly Thr Glu 
145                 150                 155                 160 


Asp Leu Pro Tyr Ala Met Lys Pro Ile Asp Tyr Tyr Thr Glu Thr Lys 
                165                 170                 175     


Ile Leu Gln Glu Arg Ala Val Leu Gly Ala Asn Asp Pro Glu Lys Asn 
            180                 185                 190         


Phe Leu Thr Thr Ala Ile Arg Pro His Gly Ile Phe Gly Pro Arg Asp 
        195                 200                 205             


Pro Gln Leu Val Pro Ile Leu Ile Glu Ala Ala Arg Asn Gly Lys Met 
    210                 215                 220                 


Lys Phe Val Ile Gly Asn Gly Lys Asn Leu Val Asp Phe Thr Phe Val 
225                 230                 235                 240 


Glu Asn Val Val His Gly His Ile Leu Ala Ala Glu Gln Leu Ser Arg 
                245                 250                 255     


Asp Ser Thr Leu Gly Gly Lys Ala Phe His Ile Thr Asn Asp Glu Pro 
            260                 265                 270         


Ile Pro Phe Trp Thr Phe Leu Ser Arg Ile Leu Thr Gly Leu Asn Tyr 
        275                 280                 285             


Glu Ala Pro Lys Tyr His Ile Pro Tyr Trp Val Ala Tyr Tyr Leu Ala 
    290                 295                 300                 


Leu Leu Leu Ser Leu Leu Val Met Val Ile Ser Pro Val Ile Gln Leu 
305                 310                 315                 320 


Gln Pro Thr Phe Thr Pro Met Arg Val Ala Leu Ala Gly Thr Phe His 
                325                 330                 335     


Tyr Tyr Ser Cys Glu Arg Ala Lys Lys Ala Met Gly Tyr Gln Pro Leu 
            340                 345                 350         


Val Thr Met Asp Asp Ala Met Glu Arg Thr Val Gln Ser Phe Arg His 
        355                 360                 365             


Leu Arg Arg Val Lys 
    370             


<210>  1384
<211>  2186
<212>  PRT
<213>  Homo sapiens

<400>  1384

Met Val Asn Glu Asn Thr Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser Thr Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Thr Thr 
                85                  90                  95      


Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Thr 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Thr Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Thr Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Thr Glu Val Gln Asp Thr Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Thr Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr Ile Leu Val Glu Thr 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Thr Arg Arg Ser Thr 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Thr Val Phe Gln Ile Leu Thr 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Thr Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Thr Thr Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Thr Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Thr Thr Ile Phe 
    930                 935                 940                 


Thr Ile Glu Ile Ala Leu Lys Ile Leu Gly Asn Ala Asp Tyr Val Phe 
945                 950                 955                 960 


Thr Ser Ile Phe Thr Leu Glu Ile Ile Leu Lys Met Thr Ala Tyr Gly 
                965                 970                 975     


Ala Phe Leu His Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu 
            980                 985                 990         


Asp Leu Leu Val Val Ser Val Ser  Leu Ile Ser Phe Gly  Ile Gln Ser 
        995                 1000                 1005             


Ser Ala  Ile Asn Val Val Lys  Ile Leu Arg Val Leu  Arg Val Leu 
    1010                 1015                 1020             


Arg Pro  Leu Arg Ala Ile Asn  Arg Ala Lys Gly Leu  Lys His Val 
    1025                 1030                 1035             


Val Gln  Cys Val Phe Val Ala  Ile Arg Thr Ile Gly  Asn Ile Val 
    1040                 1045                 1050             


Ile Val  Thr Thr Leu Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val 
    1055                 1060                 1065             


Gln Leu  Phe Lys Gly Lys Leu  Tyr Thr Cys Ser Asp  Ser Ser Lys 
    1070                 1075                 1080             


Gln Thr  Glu Ala Glu Cys Lys  Gly Asn Tyr Ile Thr  Tyr Lys Asp 
    1085                 1090                 1095             


Gly Glu  Val Asp His Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn 
    1100                 1105                 1110             


Ser Lys  Phe Asp Phe Asp Asn  Val Leu Ala Ala Met  Met Ala Leu 
    1115                 1120                 1125             


Phe Thr  Val Ser Thr Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg 
    1130                 1135                 1140             


Ser Ile  Asp Ser His Thr Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr 
    1145                 1150                 1155             


Arg Val  Glu Ile Ser Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile 
    1160                 1165                 1170             


Ala Phe  Phe Met Met Asn Ile  Phe Val Gly Phe Val  Ile Val Thr 
    1175                 1180                 1185             


Phe Gln  Glu Gln Gly Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp 
    1190                 1195                 1200             


Lys Asn  Gln Arg Gln Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro 
    1205                 1210                 1215             


Leu Arg  Arg Tyr Ile Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp 
    1220                 1225                 1230             


Tyr Val  Val Asn Ser Thr Tyr  Phe Glu Tyr Leu Met  Phe Val Leu 
    1235                 1240                 1245             


Ile Leu  Leu Asn Thr Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln 
    1250                 1255                 1260             


Ser Cys  Leu Phe Lys Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe 
    1265                 1270                 1275             


Thr Gly  Leu Phe Thr Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe 
    1280                 1285                 1290             


Lys Pro  Lys Gly Tyr Phe Ser  Asp Pro Trp Asn Val  Phe Asp Phe 
    1295                 1300                 1305             


Leu Ile  Val Ile Gly Ser Ile  Ile Asp Val Ile Leu  Ser Glu Thr 
    1310                 1315                 1320             


Asn His  Tyr Phe Cys Asp Ala  Trp Asn Thr Phe Asp  Ala Leu Ile 
    1325                 1330                 1335             


Val Val  Gly Ser Ile Val Asp  Ile Ala Ile Thr Glu  Val Asn Pro 
    1340                 1345                 1350             


Ala Glu  His Thr Gln Cys Ser  Pro Ser Met Asn Ala  Glu Glu Asn 
    1355                 1360                 1365             


Ser Arg  Ile Ser Ile Thr Phe  Phe Arg Leu Phe Arg  Val Met Arg 
    1370                 1375                 1380             


Leu Val  Lys Leu Leu Ser Arg  Gly Glu Gly Ile Arg  Thr Leu Leu 
    1385                 1390                 1395             


Trp Thr  Phe Ile Lys Ser Phe  Gln Ala Leu Pro Tyr  Val Ala Leu 
    1400                 1405                 1410             


Leu Ile  Val Met Leu Phe Phe  Ile Tyr Ala Val Ile  Gly Met Gln 
    1415                 1420                 1425             


Val Phe  Gly Lys Ile Ala Leu  Asn Asp Thr Thr Glu  Ile Asn Arg 
    1430                 1435                 1440             


Asn Asn  Asn Phe Gln Thr Phe  Pro Gln Ala Val Leu  Leu Leu Phe 
    1445                 1450                 1455             


Arg Cys  Ala Thr Gly Glu Ala  Trp Gln Asp Ile Met  Leu Ala Cys 
    1460                 1465                 1470             


Met Pro  Gly Lys Lys Cys Ala  Pro Glu Ser Glu Pro  Ser Asn Ser 
    1475                 1480                 1485             


Thr Glu  Gly Glu Thr Pro Cys  Gly Ser Ser Phe Ala  Val Phe Tyr 
    1490                 1495                 1500             


Phe Ile  Ser Phe Tyr Met Leu  Cys Ala Phe Leu Ile  Ile Asn Leu 
    1505                 1510                 1515             


Phe Val  Ala Val Ile Met Asp  Asn Phe Asp Tyr Leu  Thr Arg Asp 
    1520                 1525                 1530             


Trp Ser  Ile Leu Gly Pro His  His Leu Asp Glu Phe  Lys Arg Ile 
    1535                 1540                 1545             


Trp Ala  Glu Tyr Asp Pro Glu  Ala Lys Gly Arg Ile  Lys His Leu 
    1550                 1555                 1560             


Asp Val  Val Thr Leu Leu Arg  Arg Ile Gln Pro Pro  Leu Gly Phe 
    1565                 1570                 1575             


Gly Lys  Leu Cys Pro His Arg  Val Ala Cys Lys Arg  Leu Val Ser 
    1580                 1585                 1590             


Met Asn  Met Pro Leu Asn Ser  Asp Gly Thr Val Met  Phe Asn Ala 
    1595                 1600                 1605             


Thr Leu  Phe Ala Leu Val Arg  Thr Ala Leu Arg Ile  Lys Thr Glu 
    1610                 1615                 1620             


Gly Asn  Leu Glu Gln Ala Asn  Glu Glu Leu Arg Ala  Ile Ile Lys 
    1625                 1630                 1635             


Lys Ile  Trp Lys Arg Thr Ser  Met Lys Leu Leu Asp  Gln Val Val 
    1640                 1645                 1650             


Pro Pro  Ala Gly Asp Asp Glu  Val Thr Val Gly Lys  Phe Tyr Ala 
    1655                 1660                 1665             


Thr Phe  Leu Ile Gln Glu Tyr  Phe Arg Lys Phe Lys  Lys Arg Lys 
    1670                 1675                 1680             


Glu Gln  Gly Leu Val Gly Lys  Pro Ser Gln Arg Asn  Ala Leu Ser 
    1685                 1690                 1695             


Leu Gln  Ala Gly Leu Arg Thr  Leu His Asp Ile Gly  Pro Glu Ile 
    1700                 1705                 1710             


Arg Arg  Ala Ile Ser Gly Asp  Leu Thr Ala Glu Glu  Glu Leu Asp 
    1715                 1720                 1725             


Lys Ala  Met Lys Glu Ala Val  Ser Ala Ala Ser Glu  Asp Asp Ile 
    1730                 1735                 1740             


Phe Arg  Arg Ala Gly Gly Leu  Phe Gly Asn His Val  Ser Tyr Tyr 
    1745                 1750                 1755             


Gln Ser  Asp Gly Arg Ser Ala  Phe Pro Gln Thr Phe  Thr Thr Gln 
    1760                 1765                 1770             


Arg Pro  Leu His Ile Asn Lys  Ala Gly Ser Ser Gln  Gly Asp Thr 
    1775                 1780                 1785             


Glu Ser  Pro Ser His Glu Lys  Leu Val Asp Ser Thr  Phe Thr Pro 
    1790                 1795                 1800             


Ser Ser  Tyr Ser Ser Thr Gly  Ser Asn Ala Asn Ile  Asn Asn Ala 
    1805                 1810                 1815             


Asn Asn  Thr Ala Leu Gly Arg  Leu Pro Arg Pro Ala  Gly Tyr Pro 
    1820                 1825                 1830             


Ser Thr  Val Ser Thr Val Glu  Gly His Gly Pro Pro  Leu Ser Pro 
    1835                 1840                 1845             


Ala Ile  Arg Val Gln Glu Val  Ala Trp Lys Leu Ser  Ser Asn Arg 
    1850                 1855                 1860             


Cys His  Ser Arg Glu Ser Gln  Ala Ala Met Ala Gly  Gln Glu Glu 
    1865                 1870                 1875             


Thr Ser  Gln Asp Glu Thr Tyr  Glu Val Lys Met Asn  His Asp Thr 
    1880                 1885                 1890             


Glu Ala  Cys Ser Glu Pro Ser  Leu Leu Ser Thr Glu  Met Leu Ser 
    1895                 1900                 1905             


Tyr Gln  Asp Asp Glu Asn Arg  Gln Leu Thr Leu Pro  Glu Glu Asp 
    1910                 1915                 1920             


Lys Arg  Asp Ile Arg Gln Ser  Pro Lys Arg Gly Phe  Leu Arg Ser 
    1925                 1930                 1935             


Ala Ser  Leu Gly Arg Arg Ala  Ser Phe His Leu Glu  Cys Leu Lys 
    1940                 1945                 1950             


Arg Gln  Lys Asp Arg Gly Gly  Asp Ile Ser Gln Lys  Thr Val Leu 
    1955                 1960                 1965             


Pro Leu  His Leu Val His His  Gln Ala Leu Ala Val  Ala Gly Leu 
    1970                 1975                 1980             


Ser Pro  Leu Leu Gln Arg Ser  His Ser Pro Ala Ser  Phe Pro Arg 
    1985                 1990                 1995             


Pro Phe  Ala Thr Pro Pro Ala  Thr Pro Gly Ser Arg  Gly Trp Pro 
    2000                 2005                 2010             


Pro Gln  Pro Val Pro Thr Leu  Arg Leu Glu Gly Val  Glu Ser Ser 
    2015                 2020                 2025             


Glu Lys  Leu Asn Ser Ser Phe  Pro Ser Ile His Cys  Gly Ser Trp 
    2030                 2035                 2040             


Ala Glu  Thr Thr Pro Gly Gly  Gly Gly Ser Ser Ala  Ala Arg Arg 
    2045                 2050                 2055             


Val Arg  Pro Val Ser Leu Met  Val Pro Ser Gln Ala  Gly Ala Pro 
    2060                 2065                 2070             


Gly Arg  Gln Phe His Gly Ser  Ala Ser Ser Leu Val  Glu Ala Val 
    2075                 2080                 2085             


Leu Ile  Ser Glu Gly Leu Gly  Gln Phe Ala Gln Asp  Pro Lys Phe 
    2090                 2095                 2100             


Ile Glu  Val Thr Thr Gln Glu  Leu Ala Asp Ala Cys  Asp Met Thr 
    2105                 2110                 2115             


Ile Glu  Glu Met Glu Ser Ala  Ala Asp Asn Ile Leu  Ser Gly Gly 
    2120                 2125                 2130             


Ala Pro  Gln Ser Pro Asn Gly  Ala Leu Leu Pro Phe  Val Asn Cys 
    2135                 2140                 2145             


Arg Asp  Ala Gly Gln Asp Arg  Ala Gly Gly Glu Glu  Asp Ala Gly 
    2150                 2155                 2160             


Cys Val  Arg Ala Arg Gly Arg  Pro Ser Glu Glu Glu  Leu Gln Asp 
    2165                 2170                 2175             


Ser Arg  Val Tyr Val Ser Ser  Leu 
    2180                 2185     


<210>  1385
<211>  2179
<212>  PRT
<213>  Homo sapiens

<400>  1385

Met Val Asn Glu Asn Thr Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser Thr Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Thr Thr 
                85                  90                  95      


Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Thr 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Thr Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Thr Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Thr Glu Val Gln Asp Thr Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Thr Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr Ile Leu Val Glu Thr 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Thr Arg Arg Ser Thr 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Thr Val Phe Gln Ile Leu Thr 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Thr Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Thr Thr Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Thr Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Thr Thr Ile Phe 
    930                 935                 940                 


Thr Ile Glu Ile Ala Leu Lys Met Thr Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Thr Ile Gly  Asn Ile Val Ile Val  Thr Thr Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Thr Cys Ser Asp  Ser Ser Lys Gln Thr  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Thr  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Thr  Val Ser Thr 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Thr Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Thr Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Thr Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Thr 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Thr Gly  Leu Phe Thr 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys His Tyr 
    1265                 1270                 1275             


Phe Cys  Asp Ala Trp Asn Thr  Phe Asp Ala Leu Ile  Val Val Gly 
    1280                 1285                 1290             


Ser Ile  Val Asp Ile Ala Ile  Thr Glu Val Asn Pro  Ala Glu His 
    1295                 1300                 1305             


Thr Gln  Cys Ser Pro Ser Met  Gly Pro Ser Cys Ser  His Pro Pro 
    1310                 1315                 1320             


Leu Ala  Val Leu Thr Ala Pro  Pro Val Ala Asp Gly  Phe Gln Asn 
    1325                 1330                 1335             


Ala Glu  Glu Asn Ser Arg Ile  Ser Ile Thr Phe Phe  Arg Leu Phe 
    1340                 1345                 1350             


Arg Val  Met Arg Leu Val Lys  Leu Leu Ser Arg Gly  Glu Gly Ile 
    1355                 1360                 1365             


Arg Thr  Leu Leu Trp Thr Phe  Ile Lys Ser Phe Gln  Ala Leu Pro 
    1370                 1375                 1380             


Tyr Val  Ala Leu Leu Ile Val  Met Leu Phe Phe Ile  Tyr Ala Val 
    1385                 1390                 1395             


Ile Gly  Met Gln Val Phe Gly  Lys Ile Ala Leu Asn  Asp Thr Thr 
    1400                 1405                 1410             


Glu Ile  Asn Arg Asn Asn Asn  Phe Gln Thr Phe Pro  Gln Ala Val 
    1415                 1420                 1425             


Leu Leu  Leu Phe Arg Cys Ala  Thr Gly Glu Ala Trp  Gln Asp Ile 
    1430                 1435                 1440             


Met Leu  Ala Cys Met Pro Gly  Lys Lys Cys Ala Pro  Glu Ser Glu 
    1445                 1450                 1455             


Pro Ser  Asn Ser Thr Glu Gly  Glu Thr Pro Cys Gly  Ser Ser Phe 
    1460                 1465                 1470             


Ala Val  Phe Tyr Phe Ile Ser  Phe Tyr Met Leu Cys  Ala Phe Leu 
    1475                 1480                 1485             


Ile Ile  Asn Leu Phe Val Ala  Val Ile Met Asp Asn  Phe Asp Tyr 
    1490                 1495                 1500             


Leu Thr  Arg Asp Trp Ser Ile  Leu Gly Pro His His  Leu Asp Glu 
    1505                 1510                 1515             


Phe Lys  Arg Ile Trp Ala Glu  Tyr Asp Pro Glu Ala  Lys Gly Arg 
    1520                 1525                 1530             


Ile Lys  His Leu Asp Val Val  Thr Leu Leu Arg Arg  Ile Gln Pro 
    1535                 1540                 1545             


Pro Leu  Gly Phe Gly Lys Leu  Cys Pro His Arg Val  Ala Cys Lys 
    1550                 1555                 1560             


Arg Leu  Val Ser Met Asn Met  Pro Leu Asn Ser Asp  Gly Thr Val 
    1565                 1570                 1575             


Met Phe  Asn Ala Thr Leu Phe  Ala Leu Val Arg Thr  Ala Leu Arg 
    1580                 1585                 1590             


Ile Lys  Thr Glu Glu Gly Pro  Ser Pro Ser Glu Ala  His Gln Gly 
    1595                 1600                 1605             


Ala Glu  Asp Pro Phe Arg Pro  Ala Gly Asn Leu Glu  Gln Ala Asn 
    1610                 1615                 1620             


Glu Glu  Leu Arg Ala Ile Ile  Lys Lys Ile Trp Lys  Arg Thr Ser 
    1625                 1630                 1635             


Met Lys  Leu Leu Asp Gln Val  Val Pro Pro Ala Gly  Asp Asp Glu 
    1640                 1645                 1650             


Val Thr  Val Gly Lys Phe Tyr  Ala Thr Phe Leu Ile  Gln Glu Tyr 
    1655                 1660                 1665             


Phe Arg  Lys Phe Lys Lys Arg  Lys Glu Gln Gly Leu  Val Gly Lys 
    1670                 1675                 1680             


Pro Ser  Gln Arg Asn Ala Leu  Ser Leu Gln Ala Gly  Leu Arg Thr 
    1685                 1690                 1695             


Leu His  Asp Ile Gly Pro Glu  Ile Arg Arg Ala Ile  Ser Gly Asp 
    1700                 1705                 1710             


Leu Thr  Ala Glu Glu Glu Leu  Asp Lys Ala Met Lys  Glu Ala Val 
    1715                 1720                 1725             


Ser Ala  Ala Ser Glu Asp Asp  Ile Phe Arg Arg Ala  Gly Gly Leu 
    1730                 1735                 1740             


Phe Gly  Asn His Val Ser Tyr  Tyr Gln Ser Asp Gly  Arg Ser Ala 
    1745                 1750                 1755             


Phe Pro  Gln Thr Phe Thr Thr  Gln Arg Pro Leu His  Ile Asn Lys 
    1760                 1765                 1770             


Ala Gly  Ser Ser Gln Gly Asp  Thr Glu Ser Pro Ser  His Glu Lys 
    1775                 1780                 1785             


Leu Val  Asp Ser Thr Phe Thr  Pro Ser Ser Tyr Ser  Ser Thr Gly 
    1790                 1795                 1800             


Ser Asn  Ala Asn Ile Asn Asn  Ala Asn Asn Thr Ala  Leu Gly Arg 
    1805                 1810                 1815             


Leu Pro  Arg Pro Ala Gly Tyr  Pro Ser Thr Val Ser  Thr Val Glu 
    1820                 1825                 1830             


Gly His  Gly Pro Pro Leu Ser  Pro Ala Ile Arg Val  Gln Glu Val 
    1835                 1840                 1845             


Ala Trp  Lys Leu Ser Ser Asn  Arg Cys His Ser Arg  Glu Ser Gln 
    1850                 1855                 1860             


Ala Ala  Met Ala Gly Gln Glu  Glu Thr Ser Gln Asp  Glu Thr Tyr 
    1865                 1870                 1875             


Glu Val  Lys Met Asn His Asp  Thr Glu Ala Cys Ser  Glu Pro Ser 
    1880                 1885                 1890             


Leu Leu  Ser Thr Glu Met Leu  Ser Tyr Gln Asp Asp  Glu Asn Arg 
    1895                 1900                 1905             


Gln Leu  Thr Leu Pro Glu Glu  Asp Lys Arg Asp Ile  Arg Gln Ser 
    1910                 1915                 1920             


Pro Lys  Arg Gly Phe Leu Arg  Ser Ala Ser Leu Gly  Arg Arg Ala 
    1925                 1930                 1935             


Ser Phe  His Leu Glu Cys Leu  Lys Arg Gln Lys Asp  Arg Gly Gly 
    1940                 1945                 1950             


Asp Ile  Ser Gln Lys Thr Val  Leu Pro Leu His Leu  Val His His 
    1955                 1960                 1965             


Gln Ala  Leu Ala Val Ala Gly  Leu Ser Pro Leu Leu  Gln Arg Ser 
    1970                 1975                 1980             


His Ser  Pro Ala Ser Phe Pro  Arg Pro Phe Ala Thr  Pro Pro Ala 
    1985                 1990                 1995             


Thr Pro  Gly Ser Arg Gly Trp  Pro Pro Gln Pro Val  Pro Thr Leu 
    2000                 2005                 2010             


Arg Leu  Glu Gly Val Glu Ser  Ser Glu Lys Leu Asn  Ser Ser Phe 
    2015                 2020                 2025             


Pro Ser  Ile His Cys Gly Ser  Trp Ala Glu Thr Thr  Pro Gly Gly 
    2030                 2035                 2040             


Gly Gly  Ser Ser Ala Ala Arg  Arg Val Arg Pro Val  Ser Leu Met 
    2045                 2050                 2055             


Val Pro  Ser Gln Ala Gly Ala  Pro Gly Arg Gln Phe  His Gly Ser 
    2060                 2065                 2070             


Ala Ser  Ser Leu Val Glu Ala  Val Leu Ile Ser Glu  Gly Leu Gly 
    2075                 2080                 2085             


Gln Phe  Ala Gln Asp Pro Lys  Phe Ile Glu Val Thr  Thr Gln Glu 
    2090                 2095                 2100             


Leu Ala  Asp Ala Cys Asp Met  Thr Ile Glu Glu Met  Glu Ser Ala 
    2105                 2110                 2115             


Ala Asp  Asn Ile Leu Ser Gly  Gly Ala Pro Gln Ser  Pro Asn Gly 
    2120                 2125                 2130             


Ala Leu  Leu Pro Phe Val Asn  Cys Arg Asp Ala Gly  Gln Asp Arg 
    2135                 2140                 2145             


Ala Gly  Gly Glu Glu Asp Ala  Gly Cys Val Arg Ala  Arg Gly Arg 
    2150                 2155                 2160             


Pro Ser  Glu Glu Glu Leu Gln  Asp Ser Arg Val Tyr  Val Ser Ser 
    2165                 2170                 2175             


Leu 
    


<210>  1386
<211>  2173
<212>  PRT
<213>  Homo sapiens

<400>  1386

Met Val Asn Glu Asn Thr Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser Thr Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Thr Thr 
                85                  90                  95      


Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Thr 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Thr Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Thr Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Thr Glu Val Gln Asp Thr Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Thr Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr Ile Leu Val Glu Thr 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Thr Arg Arg Ser Thr 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Thr Val Phe Gln Ile Leu Thr 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Thr Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Thr Thr Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Thr Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Gly Asn Ala Asp Tyr Val Phe Thr Ser Ile Phe 
    930                 935                 940                 


Thr Leu Glu Ile Ile Leu Lys Met Thr Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Thr Ile Gly  Asn Ile Val Ile Val  Thr Thr Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Thr Cys Ser Asp  Ser Ser Lys Gln Thr  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Thr  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Thr  Val Ser Thr 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Thr Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Thr Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Thr Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Thr 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Thr Gly  Leu Phe Thr 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys His Tyr 
    1265                 1270                 1275             


Phe Cys  Asp Ala Trp Asn Thr  Phe Asp Ala Leu Ile  Val Val Gly 
    1280                 1285                 1290             


Ser Ile  Val Asp Ile Ala Ile  Thr Glu Val Asn Pro  Ala Glu His 
    1295                 1300                 1305             


Thr Gln  Cys Ser Pro Ser Met  Asn Ala Glu Glu Asn  Ser Arg Ile 
    1310                 1315                 1320             


Ser Ile  Thr Phe Phe Arg Leu  Phe Arg Val Met Arg  Leu Val Lys 
    1325                 1330                 1335             


Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Thr Leu Leu  Trp Thr Phe 
    1340                 1345                 1350             


Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Val 
    1355                 1360                 1365             


Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly Met Gln  Val Phe Gly 
    1370                 1375                 1380             


Lys Ile  Ala Leu Asn Asp Thr  Thr Glu Ile Asn Arg  Asn Asn Asn 
    1385                 1390                 1395             


Phe Gln  Thr Phe Pro Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala 
    1400                 1405                 1410             


Thr Gly  Glu Ala Trp Gln Asp  Ile Met Leu Ala Cys  Met Pro Gly 
    1415                 1420                 1425             


Lys Lys  Cys Ala Pro Glu Ser  Glu Pro Ser Asn Ser  Thr Glu Gly 
    1430                 1435                 1440             


Glu Thr  Pro Cys Gly Ser Ser  Phe Ala Val Phe Tyr  Phe Ile Ser 
    1445                 1450                 1455             


Phe Tyr  Met Leu Cys Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala 
    1460                 1465                 1470             


Val Ile  Met Asp Asn Phe Asp  Tyr Leu Thr Arg Asp  Trp Ser Ile 
    1475                 1480                 1485             


Leu Gly  Pro His His Leu Asp  Glu Phe Lys Arg Ile  Trp Ala Glu 
    1490                 1495                 1500             


Tyr Asp  Pro Glu Ala Lys Gly  Arg Ile Lys His Leu  Asp Val Val 
    1505                 1510                 1515             


Thr Leu  Leu Arg Arg Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu 
    1520                 1525                 1530             


Cys Pro  His Arg Val Ala Cys  Lys Arg Leu Val Ser  Met Asn Met 
    1535                 1540                 1545             


Pro Leu  Asn Ser Asp Gly Thr  Val Met Phe Asn Ala  Thr Leu Phe 
    1550                 1555                 1560             


Ala Leu  Val Arg Thr Ala Leu  Arg Ile Lys Thr Glu  Gly Asn Leu 
    1565                 1570                 1575             


Glu Gln  Ala Asn Glu Glu Leu  Arg Ala Ile Ile Lys  Lys Ile Trp 
    1580                 1585                 1590             


Lys Arg  Thr Ser Met Lys Leu  Leu Asp Gln Val Val  Pro Pro Ala 
    1595                 1600                 1605             


Gly Asp  Asp Glu Val Thr Val  Gly Lys Phe Tyr Ala  Thr Phe Leu 
    1610                 1615                 1620             


Ile Gln  Glu Tyr Phe Arg Lys  Phe Lys Lys Arg Lys  Glu Gln Gly 
    1625                 1630                 1635             


Leu Val  Gly Lys Pro Ser Gln  Arg Asn Ala Leu Ser  Leu Gln Ala 
    1640                 1645                 1650             


Gly Leu  Arg Thr Leu His Asp  Ile Gly Pro Glu Ile  Arg Arg Ala 
    1655                 1660                 1665             


Ile Ser  Gly Asp Leu Thr Ala  Glu Glu Glu Leu Asp  Lys Ala Met 
    1670                 1675                 1680             


Lys Glu  Ala Val Ser Ala Ala  Ser Glu Asp Asp Ile  Phe Arg Arg 
    1685                 1690                 1695             


Ala Gly  Gly Leu Phe Gly Asn  His Val Ser Tyr Tyr  Gln Ser Asp 
    1700                 1705                 1710             


Gly Arg  Ser Ala Phe Pro Gln  Thr Phe Thr Thr Gln  Arg Pro Leu 
    1715                 1720                 1725             


His Ile  Asn Lys Ala Gly Ser  Ser Gln Gly Asp Thr  Glu Ser Pro 
    1730                 1735                 1740             


Ser His  Glu Lys Leu Val Asp  Ser Thr Phe Thr Pro  Ser Ser Tyr 
    1745                 1750                 1755             


Ser Ser  Thr Gly Ser Asn Ala  Asn Ile Asn Asn Ala  Asn Asn Thr 
    1760                 1765                 1770             


Ala Leu  Gly Arg Leu Pro Arg  Pro Ala Gly Tyr Pro  Ser Thr Val 
    1775                 1780                 1785             


Ser Thr  Val Glu Gly His Gly  Pro Pro Leu Ser Pro  Ala Ile Arg 
    1790                 1795                 1800             


Val Gln  Glu Val Ala Trp Lys  Leu Ser Ser Asn Arg  Glu Arg His 
    1805                 1810                 1815             


Val Pro  Met Cys Glu Asp Leu  Glu Leu Arg Arg Asp  Ser Gly Ser 
    1820                 1825                 1830             


Ala Gly  Thr Gln Ala His Cys  Leu Leu Leu Arg Arg  Ala Asn Pro 
    1835                 1840                 1845             


Ser Arg  Cys His Ser Arg Glu  Ser Gln Ala Ala Met  Ala Gly Gln 
    1850                 1855                 1860             


Glu Glu  Thr Ser Gln Asp Glu  Thr Tyr Glu Val Lys  Met Asn His 
    1865                 1870                 1875             


Asp Thr  Glu Ala Cys Ser Glu  Pro Ser Leu Leu Ser  Thr Glu Met 
    1880                 1885                 1890             


Leu Ser  Tyr Gln Asp Asp Glu  Asn Arg Gln Leu Thr  Leu Pro Glu 
    1895                 1900                 1905             


Glu Asp  Lys Arg Asp Ile Arg  Gln Ser Pro Lys Arg  Gly Phe Leu 
    1910                 1915                 1920             


Arg Ser  Ala Ser Leu Gly Arg  Arg Ala Ser Phe His  Leu Glu Cys 
    1925                 1930                 1935             


Leu Lys  Arg Gln Lys Asp Arg  Gly Gly Asp Ile Ser  Gln Lys Thr 
    1940                 1945                 1950             


Val Leu  Pro Leu His Leu Val  His His Gln Ala Leu  Ala Val Ala 
    1955                 1960                 1965             


Gly Leu  Ser Pro Leu Leu Gln  Arg Ser His Ser Pro  Ala Ser Phe 
    1970                 1975                 1980             


Pro Arg  Pro Phe Ala Thr Pro  Pro Ala Thr Pro Gly  Ser Arg Gly 
    1985                 1990                 1995             


Trp Pro  Pro Gln Pro Val Pro  Thr Leu Arg Leu Glu  Gly Val Glu 
    2000                 2005                 2010             


Ser Ser  Glu Lys Leu Asn Ser  Ser Phe Pro Ser Ile  His Cys Gly 
    2015                 2020                 2025             


Ser Trp  Ala Glu Thr Thr Pro  Gly Gly Gly Gly Ser  Ser Ala Ala 
    2030                 2035                 2040             


Arg Arg  Val Arg Pro Val Ser  Leu Met Val Pro Ser  Gln Ala Gly 
    2045                 2050                 2055             


Ala Pro  Gly Arg Gln Phe His  Gly Ser Ala Ser Ser  Leu Val Glu 
    2060                 2065                 2070             


Ala Val  Leu Ile Ser Glu Gly  Leu Gly Gln Phe Ala  Gln Asp Pro 
    2075                 2080                 2085             


Lys Phe  Ile Glu Val Thr Thr  Gln Glu Leu Ala Asp  Ala Cys Asp 
    2090                 2095                 2100             


Met Thr  Ile Glu Glu Met Glu  Ser Ala Ala Asp Asn  Ile Leu Ser 
    2105                 2110                 2115             


Gly Gly  Ala Pro Gln Ser Pro  Asn Gly Ala Leu Leu  Pro Phe Val 
    2120                 2125                 2130             


Asn Cys  Arg Asp Ala Gly Gln  Asp Arg Ala Gly Gly  Glu Glu Asp 
    2135                 2140                 2145             


Ala Gly  Cys Val Arg Ala Arg  Gly Arg Pro Ser Glu  Glu Glu Leu 
    2150                 2155                 2160             


Gln Asp  Ser Arg Val Tyr Val  Ser Ser Leu 
    2165                 2170             


<210>  1387
<211>  2166
<212>  PRT
<213>  Homo sapiens

<400>  1387

Met Val Asn Glu Asn Thr Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser Thr Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Thr Thr 
                85                  90                  95      


Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Thr 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Thr Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Thr Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Thr Glu Val Gln Asp Thr Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Thr Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr Ile Leu Val Glu Thr 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Thr Arg Arg Ser Thr 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Thr Val Phe Gln Ile Leu Thr 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Thr Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Thr Thr Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Thr Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Thr Thr Ile Phe 
    930                 935                 940                 


Thr Ile Glu Ile Ala Leu Lys Met Thr Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Thr Ile Gly  Asn Ile Val Ile Val  Thr Thr Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Thr Cys Ser Asp  Ser Ser Lys Gln Thr  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Thr  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Thr  Val Ser Thr 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Thr Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Thr Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Thr Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Thr 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Thr Gly  Leu Phe Thr 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys Gly Tyr 
    1265                 1270                 1275             


Phe Ser  Asp Pro Trp Asn Val  Phe Asp Phe Leu Ile  Val Ile Gly 
    1280                 1285                 1290             


Ser Ile  Ile Asp Val Ile Leu  Ser Glu Thr Asn His  Tyr Phe Cys 
    1295                 1300                 1305             


Asp Ala  Trp Asn Thr Phe Asp  Ala Leu Ile Val Val  Gly Ser Ile 
    1310                 1315                 1320             


Val Asp  Ile Ala Ile Thr Glu  Val Asn Pro Ala Glu  His Thr Gln 
    1325                 1330                 1335             


Cys Ser  Pro Ser Met Asn Ala  Glu Glu Asn Ser Arg  Ile Ser Ile 
    1340                 1345                 1350             


Thr Phe  Phe Arg Leu Phe Arg  Val Met Arg Leu Val  Lys Leu Leu 
    1355                 1360                 1365             


Ser Arg  Gly Glu Gly Ile Arg  Thr Leu Leu Trp Thr  Phe Ile Lys 
    1370                 1375                 1380             


Ser Phe  Gln Ala Leu Pro Tyr  Val Ala Leu Leu Ile  Val Met Leu 
    1385                 1390                 1395             


Phe Phe  Ile Tyr Ala Val Ile  Gly Met Gln Val Phe  Gly Lys Ile 
    1400                 1405                 1410             


Ala Leu  Asn Asp Thr Thr Glu  Ile Asn Arg Asn Asn  Asn Phe Gln 
    1415                 1420                 1425             


Thr Phe  Pro Gln Ala Val Leu  Leu Leu Phe Arg Cys  Ala Thr Gly 
    1430                 1435                 1440             


Glu Ala  Trp Gln Asp Ile Met  Leu Ala Cys Met Pro  Gly Lys Lys 
    1445                 1450                 1455             


Cys Ala  Pro Glu Ser Glu Pro  Ser Asn Ser Thr Glu  Gly Glu Thr 
    1460                 1465                 1470             


Pro Cys  Gly Ser Ser Phe Ala  Val Phe Tyr Phe Ile  Ser Phe Tyr 
    1475                 1480                 1485             


Met Leu  Cys Ala Phe Leu Ile  Ile Asn Leu Phe Val  Ala Val Ile 
    1490                 1495                 1500             


Met Asp  Asn Phe Asp Tyr Leu  Thr Arg Asp Trp Ser  Ile Leu Gly 
    1505                 1510                 1515             


Pro His  His Leu Asp Glu Phe  Lys Arg Ile Trp Ala  Glu Tyr Asp 
    1520                 1525                 1530             


Pro Glu  Ala Lys Gly Arg Ile  Lys His Leu Asp Val  Val Thr Leu 
    1535                 1540                 1545             


Leu Arg  Arg Ile Gln Pro Pro  Leu Gly Phe Gly Lys  Leu Cys Pro 
    1550                 1555                 1560             


His Arg  Val Ala Cys Lys Arg  Leu Val Ser Met Asn  Met Pro Leu 
    1565                 1570                 1575             


Asn Ser  Asp Gly Thr Val Met  Phe Asn Ala Thr Leu  Phe Ala Leu 
    1580                 1585                 1590             


Val Arg  Thr Ala Leu Arg Ile  Lys Thr Glu Gly Asn  Leu Glu Gln 
    1595                 1600                 1605             


Ala Asn  Glu Glu Leu Arg Ala  Ile Ile Lys Lys Ile  Trp Lys Arg 
    1610                 1615                 1620             


Thr Ser  Met Lys Leu Leu Asp  Gln Val Val Pro Pro  Ala Gly Asp 
    1625                 1630                 1635             


Asp Glu  Val Thr Val Gly Lys  Phe Tyr Ala Thr Phe  Leu Ile Gln 
    1640                 1645                 1650             


Glu Tyr  Phe Arg Lys Phe Lys  Lys Arg Lys Glu Gln  Gly Leu Val 
    1655                 1660                 1665             


Gly Lys  Pro Ser Gln Arg Asn  Ala Leu Ser Leu Gln  Ala Gly Leu 
    1670                 1675                 1680             


Arg Thr  Leu His Asp Ile Gly  Pro Glu Ile Arg Arg  Ala Ile Ser 
    1685                 1690                 1695             


Gly Asp  Leu Thr Ala Glu Glu  Glu Leu Asp Lys Ala  Met Lys Glu 
    1700                 1705                 1710             


Ala Val  Ser Ala Ala Ser Glu  Asp Asp Ile Phe Arg  Arg Ala Gly 
    1715                 1720                 1725             


Gly Leu  Phe Gly Asn His Val  Ser Tyr Tyr Gln Ser  Asp Gly Arg 
    1730                 1735                 1740             


Ser Ala  Phe Pro Gln Thr Phe  Thr Thr Gln Arg Pro  Leu His Ile 
    1745                 1750                 1755             


Asn Lys  Ala Gly Ser Ser Gln  Gly Asp Thr Glu Ser  Pro Ser His 
    1760                 1765                 1770             


Glu Lys  Leu Val Asp Ser Thr  Phe Thr Pro Ser Ser  Tyr Ser Ser 
    1775                 1780                 1785             


Thr Gly  Ser Asn Ala Asn Ile  Asn Asn Ala Asn Asn  Thr Ala Leu 
    1790                 1795                 1800             


Gly Arg  Leu Pro Arg Pro Ala  Gly Tyr Pro Ser Thr  Val Ser Thr 
    1805                 1810                 1815             


Val Glu  Gly His Gly Pro Pro  Leu Ser Pro Ala Ile  Arg Val Gln 
    1820                 1825                 1830             


Glu Val  Ala Trp Lys Leu Ser  Ser Asn Arg Cys His  Ser Arg Glu 
    1835                 1840                 1845             


Ser Gln  Ala Ala Met Ala Gly  Gln Glu Glu Thr Ser  Gln Asp Glu 
    1850                 1855                 1860             


Thr Tyr  Glu Val Lys Met Asn  His Asp Thr Glu Ala  Cys Ser Glu 
    1865                 1870                 1875             


Pro Ser  Leu Leu Ser Thr Glu  Met Leu Ser Tyr Gln  Asp Asp Glu 
    1880                 1885                 1890             


Asn Arg  Gln Leu Thr Leu Pro  Glu Glu Asp Lys Arg  Asp Ile Arg 
    1895                 1900                 1905             


Gln Ser  Pro Lys Arg Gly Phe  Leu Arg Ser Ala Ser  Leu Gly Arg 
    1910                 1915                 1920             


Arg Ala  Ser Phe His Leu Glu  Cys Leu Lys Arg Gln  Lys Asp Arg 
    1925                 1930                 1935             


Gly Gly  Asp Ile Ser Gln Lys  Thr Val Leu Pro Leu  His Leu Val 
    1940                 1945                 1950             


His His  Gln Ala Leu Ala Val  Ala Gly Leu Ser Pro  Leu Leu Gln 
    1955                 1960                 1965             


Arg Ser  His Ser Pro Ala Ser  Phe Pro Arg Pro Phe  Ala Thr Pro 
    1970                 1975                 1980             


Pro Ala  Thr Pro Gly Ser Arg  Gly Trp Pro Pro Gln  Pro Val Pro 
    1985                 1990                 1995             


Thr Leu  Arg Leu Glu Gly Val  Glu Ser Ser Glu Lys  Leu Asn Ser 
    2000                 2005                 2010             


Ser Phe  Pro Ser Ile His Cys  Gly Ser Trp Ala Glu  Thr Thr Pro 
    2015                 2020                 2025             


Gly Gly  Gly Gly Ser Ser Ala  Ala Arg Arg Val Arg  Pro Val Ser 
    2030                 2035                 2040             


Leu Met  Val Pro Ser Gln Ala  Gly Ala Pro Gly Arg  Gln Phe His 
    2045                 2050                 2055             


Gly Ser  Ala Ser Ser Leu Val  Glu Ala Val Leu Ile  Ser Glu Gly 
    2060                 2065                 2070             


Leu Gly  Gln Phe Ala Gln Asp  Pro Lys Phe Ile Glu  Val Thr Thr 
    2075                 2080                 2085             


Gln Glu  Leu Ala Asp Ala Cys  Asp Met Thr Ile Glu  Glu Met Glu 
    2090                 2095                 2100             


Ser Ala  Ala Asp Asn Ile Leu  Ser Gly Gly Ala Pro  Gln Ser Pro 
    2105                 2110                 2115             


Asn Gly  Ala Leu Leu Pro Phe  Val Asn Cys Arg Asp  Ala Gly Gln 
    2120                 2125                 2130             


Asp Arg  Ala Gly Gly Glu Glu  Asp Ala Gly Cys Val  Arg Ala Arg 
    2135                 2140                 2145             


Gly Arg  Pro Ser Glu Glu Glu  Leu Gln Asp Ser Arg  Val Tyr Val 
    2150                 2155                 2160             


Ser Ser  Leu 
    2165     


<210>  1388
<211>  2158
<212>  PRT
<213>  Homo sapiens

<400>  1388

Met Val Asn Glu Asn Thr Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser Thr Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Thr Thr 
                85                  90                  95      


Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Thr 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Thr Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Thr Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Thr Glu Val Gln Asp Thr Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Thr Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr Ile Leu Val Glu Thr 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Thr Arg Arg Ser Thr 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Thr Val Phe Gln Ile Leu Thr 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Thr Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Thr Thr Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Thr Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Thr Thr Ile Phe 
    930                 935                 940                 


Thr Ile Glu Ile Ala Leu Lys Ile Leu Gly Asn Ala Asp Tyr Val Phe 
945                 950                 955                 960 


Thr Ser Ile Phe Thr Leu Glu Ile Ile Leu Lys Met Thr Ala Tyr Gly 
                965                 970                 975     


Ala Phe Leu His Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu 
            980                 985                 990         


Asp Leu Leu Val Val Ser Val Ser  Leu Ile Ser Phe Gly  Ile Gln Ser 
        995                 1000                 1005             


Ser Ala  Ile Asn Val Val Lys  Ile Leu Arg Val Leu  Arg Val Leu 
    1010                 1015                 1020             


Arg Pro  Leu Arg Ala Ile Asn  Arg Ala Lys Gly Leu  Lys His Val 
    1025                 1030                 1035             


Val Gln  Cys Val Phe Val Ala  Ile Arg Thr Ile Gly  Asn Ile Val 
    1040                 1045                 1050             


Ile Val  Thr Thr Leu Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val 
    1055                 1060                 1065             


Gln Leu  Phe Lys Gly Lys Leu  Tyr Thr Cys Ser Asp  Ser Ser Lys 
    1070                 1075                 1080             


Gln Thr  Glu Ala Glu Cys Lys  Gly Asn Tyr Ile Thr  Tyr Lys Asp 
    1085                 1090                 1095             


Gly Glu  Val Asp His Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn 
    1100                 1105                 1110             


Ser Lys  Phe Asp Phe Asp Asn  Val Leu Ala Ala Met  Met Ala Leu 
    1115                 1120                 1125             


Phe Thr  Val Ser Thr Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg 
    1130                 1135                 1140             


Ser Ile  Asp Ser His Thr Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr 
    1145                 1150                 1155             


Arg Val  Glu Ile Ser Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile 
    1160                 1165                 1170             


Ala Phe  Phe Met Met Asn Ile  Phe Val Gly Phe Val  Ile Val Thr 
    1175                 1180                 1185             


Phe Gln  Glu Gln Gly Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp 
    1190                 1195                 1200             


Lys Asn  Gln Arg Gln Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro 
    1205                 1210                 1215             


Leu Arg  Arg Tyr Ile Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp 
    1220                 1225                 1230             


Tyr Val  Val Asn Ser Thr Tyr  Phe Glu Tyr Leu Met  Phe Val Leu 
    1235                 1240                 1245             


Ile Leu  Leu Asn Thr Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln 
    1250                 1255                 1260             


Ser Cys  Leu Phe Lys Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe 
    1265                 1270                 1275             


Thr Gly  Leu Phe Thr Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe 
    1280                 1285                 1290             


Lys Pro  Lys His Tyr Phe Cys  Asp Ala Trp Asn Thr  Phe Asp Ala 
    1295                 1300                 1305             


Leu Ile  Val Val Gly Ser Ile  Val Asp Ile Ala Ile  Thr Glu Val 
    1310                 1315                 1320             


Asn Pro  Ala Glu His Thr Gln  Cys Ser Pro Ser Met  Asn Ala Glu 
    1325                 1330                 1335             


Glu Asn  Ser Arg Ile Ser Ile  Thr Phe Phe Arg Leu  Phe Arg Val 
    1340                 1345                 1350             


Met Arg  Leu Val Lys Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Thr 
    1355                 1360                 1365             


Leu Leu  Trp Thr Phe Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val 
    1370                 1375                 1380             


Ala Leu  Leu Ile Val Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly 
    1385                 1390                 1395             


Met Gln  Val Phe Gly Lys Ile  Ala Leu Asn Asp Thr  Thr Glu Ile 
    1400                 1405                 1410             


Asn Arg  Asn Asn Asn Phe Gln  Thr Phe Pro Gln Ala  Val Leu Leu 
    1415                 1420                 1425             


Leu Phe  Arg Cys Ala Thr Gly  Glu Ala Trp Gln Asp  Ile Met Leu 
    1430                 1435                 1440             


Ala Cys  Met Pro Gly Lys Lys  Cys Ala Pro Glu Ser  Glu Pro Ser 
    1445                 1450                 1455             


Asn Ser  Thr Glu Gly Glu Thr  Pro Cys Gly Ser Ser  Phe Ala Val 
    1460                 1465                 1470             


Phe Tyr  Phe Ile Ser Phe Tyr  Met Leu Cys Ala Phe  Leu Ile Ile 
    1475                 1480                 1485             


Asn Leu  Phe Val Ala Val Ile  Met Asp Asn Phe Asp  Tyr Leu Thr 
    1490                 1495                 1500             


Arg Asp  Trp Ser Ile Leu Gly  Pro His His Leu Asp  Glu Phe Lys 
    1505                 1510                 1515             


Arg Ile  Trp Ala Glu Tyr Asp  Pro Glu Ala Lys Gly  Arg Ile Lys 
    1520                 1525                 1530             


His Leu  Asp Val Val Thr Leu  Leu Arg Arg Ile Gln  Pro Pro Leu 
    1535                 1540                 1545             


Gly Phe  Gly Lys Leu Cys Pro  His Arg Val Ala Cys  Lys Arg Leu 
    1550                 1555                 1560             


Val Ser  Met Asn Met Pro Leu  Asn Ser Asp Gly Thr  Val Met Phe 
    1565                 1570                 1575             


Asn Ala  Thr Leu Phe Ala Leu  Val Arg Thr Ala Leu  Arg Ile Lys 
    1580                 1585                 1590             


Thr Glu  Gly Asn Leu Glu Gln  Ala Asn Glu Glu Leu  Arg Ala Ile 
    1595                 1600                 1605             


Ile Lys  Lys Ile Trp Lys Arg  Thr Ser Met Lys Leu  Leu Asp Gln 
    1610                 1615                 1620             


Val Val  Pro Pro Ala Gly Asp  Asp Glu Val Thr Val  Gly Lys Phe 
    1625                 1630                 1635             


Tyr Ala  Thr Phe Leu Ile Gln  Glu Tyr Phe Arg Lys  Phe Lys Lys 
    1640                 1645                 1650             


Arg Lys  Glu Gln Gly Leu Val  Gly Lys Pro Ser Gln  Arg Asn Ala 
    1655                 1660                 1665             


Leu Ser  Leu Gln Ala Gly Leu  Arg Thr Leu His Asp  Ile Gly Pro 
    1670                 1675                 1680             


Glu Ile  Arg Arg Ala Ile Ser  Gly Asp Leu Thr Ala  Glu Glu Glu 
    1685                 1690                 1695             


Leu Asp  Lys Ala Met Lys Glu  Ala Val Ser Ala Ala  Ser Glu Asp 
    1700                 1705                 1710             


Asp Ile  Phe Arg Arg Ala Gly  Gly Leu Phe Gly Asn  His Val Ser 
    1715                 1720                 1725             


Tyr Tyr  Gln Ser Asp Gly Arg  Ser Ala Phe Pro Gln  Thr Phe Thr 
    1730                 1735                 1740             


Thr Gln  Arg Pro Leu His Ile  Asn Lys Ala Gly Ser  Ser Gln Gly 
    1745                 1750                 1755             


Asp Thr  Glu Ser Pro Ser His  Glu Lys Leu Val Asp  Ser Thr Phe 
    1760                 1765                 1770             


Thr Pro  Ser Ser Tyr Ser Ser  Thr Gly Ser Asn Ala  Asn Ile Asn 
    1775                 1780                 1785             


Asn Ala  Asn Asn Thr Ala Leu  Gly Arg Leu Pro Arg  Pro Ala Gly 
    1790                 1795                 1800             


Tyr Pro  Ser Thr Val Ser Thr  Val Glu Gly His Gly  Pro Pro Leu 
    1805                 1810                 1815             


Ser Pro  Ala Ile Arg Val Gln  Glu Val Ala Trp Lys  Leu Ser Ser 
    1820                 1825                 1830             


Asn Arg  Cys His Ser Arg Glu  Ser Gln Ala Ala Met  Ala Gly Gln 
    1835                 1840                 1845             


Glu Glu  Thr Ser Gln Asp Glu  Thr Tyr Glu Val Lys  Met Asn His 
    1850                 1855                 1860             


Asp Thr  Glu Ala Cys Ser Glu  Pro Ser Leu Leu Ser  Thr Glu Met 
    1865                 1870                 1875             


Leu Ser  Tyr Gln Asp Asp Glu  Asn Arg Gln Leu Thr  Leu Pro Glu 
    1880                 1885                 1890             


Glu Asp  Lys Arg Asp Ile Arg  Gln Ser Pro Lys Arg  Gly Phe Leu 
    1895                 1900                 1905             


Arg Ser  Ala Ser Leu Gly Arg  Arg Ala Ser Phe His  Leu Glu Cys 
    1910                 1915                 1920             


Leu Lys  Arg Gln Lys Asp Arg  Gly Gly Asp Ile Ser  Gln Lys Thr 
    1925                 1930                 1935             


Val Leu  Pro Leu His Leu Val  His His Gln Ala Leu  Ala Val Ala 
    1940                 1945                 1950             


Gly Leu  Ser Pro Leu Leu Gln  Arg Ser His Ser Pro  Ala Ser Phe 
    1955                 1960                 1965             


Pro Arg  Pro Phe Ala Thr Pro  Pro Ala Thr Pro Gly  Ser Arg Gly 
    1970                 1975                 1980             


Trp Pro  Pro Gln Pro Val Pro  Thr Leu Arg Leu Glu  Gly Val Glu 
    1985                 1990                 1995             


Ser Ser  Glu Lys Leu Asn Ser  Ser Phe Pro Ser Ile  His Cys Gly 
    2000                 2005                 2010             


Ser Trp  Ala Glu Thr Thr Pro  Gly Gly Gly Gly Ser  Ser Ala Ala 
    2015                 2020                 2025             


Arg Arg  Val Arg Pro Val Ser  Leu Met Val Pro Ser  Gln Ala Gly 
    2030                 2035                 2040             


Ala Pro  Gly Arg Gln Phe His  Gly Ser Ala Ser Ser  Leu Val Glu 
    2045                 2050                 2055             


Ala Val  Leu Ile Ser Glu Gly  Leu Gly Gln Phe Ala  Gln Asp Pro 
    2060                 2065                 2070             


Lys Phe  Ile Glu Val Thr Thr  Gln Glu Leu Ala Asp  Ala Cys Asp 
    2075                 2080                 2085             


Met Thr  Ile Glu Glu Met Glu  Ser Ala Ala Asp Asn  Ile Leu Ser 
    2090                 2095                 2100             


Gly Gly  Ala Pro Gln Ser Pro  Asn Gly Ala Leu Leu  Pro Phe Val 
    2105                 2110                 2115             


Asn Cys  Arg Asp Ala Gly Gln  Asp Arg Ala Gly Gly  Glu Glu Asp 
    2120                 2125                 2130             


Ala Gly  Cys Val Arg Ala Arg  Gly Arg Pro Ser Glu  Glu Glu Leu 
    2135                 2140                 2145             


Gln Asp  Ser Arg Val Tyr Val  Ser Ser Leu 
    2150                 2155             


<210>  1389
<211>  2157
<212>  PRT
<213>  Homo sapiens

<400>  1389

Met Val Asn Glu Asn Thr Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser Thr Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Thr Thr 
                85                  90                  95      


Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Thr 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Thr Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Thr Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Thr Glu Val Gln Asp Thr Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Thr Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr Ile Leu Val Glu Thr 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Thr Arg Arg Ser Thr 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Thr Val Phe Gln Ile Leu Thr 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Thr Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Thr Thr Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Thr Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Thr Thr Ile Phe 
    930                 935                 940                 


Thr Ile Glu Ile Ala Leu Lys Met Thr Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Thr Ile Gly  Asn Ile Val Ile Val  Thr Thr Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Thr Cys Ser Asp  Ser Ser Lys Gln Thr  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Thr  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Thr  Val Ser Thr 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Thr Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Thr Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Thr Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Thr 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Thr Gly  Leu Phe Thr 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys Gly Tyr 
    1265                 1270                 1275             


Phe Ser  Asp Pro Trp Asn Val  Phe Asp Phe Leu Ile  Val Ile Gly 
    1280                 1285                 1290             


Ser Ile  Ile Asp Val Ile Leu  Ser Glu Thr Asn Pro  Ala Glu His 
    1295                 1300                 1305             


Thr Gln  Cys Ser Pro Ser Met  Asn Ala Glu Glu Asn  Ser Arg Ile 
    1310                 1315                 1320             


Ser Ile  Thr Phe Phe Arg Leu  Phe Arg Val Met Arg  Leu Val Lys 
    1325                 1330                 1335             


Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Thr Leu Leu  Trp Thr Phe 
    1340                 1345                 1350             


Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Val 
    1355                 1360                 1365             


Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly Met Gln  Val Phe Gly 
    1370                 1375                 1380             


Lys Ile  Ala Leu Asn Asp Thr  Thr Glu Ile Asn Arg  Asn Asn Asn 
    1385                 1390                 1395             


Phe Gln  Thr Phe Pro Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala 
    1400                 1405                 1410             


Thr Gly  Glu Ala Trp Gln Asp  Ile Met Leu Ala Cys  Met Pro Gly 
    1415                 1420                 1425             


Lys Lys  Cys Ala Pro Glu Ser  Glu Pro Ser Asn Ser  Thr Glu Gly 
    1430                 1435                 1440             


Glu Thr  Pro Cys Gly Ser Ser  Phe Ala Val Phe Tyr  Phe Ile Ser 
    1445                 1450                 1455             


Phe Tyr  Met Leu Cys Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala 
    1460                 1465                 1470             


Val Ile  Met Asp Asn Phe Asp  Tyr Leu Thr Arg Asp  Trp Ser Ile 
    1475                 1480                 1485             


Leu Gly  Pro His His Leu Asp  Glu Phe Lys Arg Ile  Trp Ala Glu 
    1490                 1495                 1500             


Tyr Asp  Pro Glu Ala Lys Gly  Arg Ile Lys His Leu  Asp Val Val 
    1505                 1510                 1515             


Thr Leu  Leu Arg Arg Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu 
    1520                 1525                 1530             


Cys Pro  His Arg Val Ala Cys  Lys Arg Leu Val Ser  Met Asn Met 
    1535                 1540                 1545             


Pro Leu  Asn Ser Asp Gly Thr  Val Met Phe Asn Ala  Thr Leu Phe 
    1550                 1555                 1560             


Ala Leu  Val Arg Thr Ala Leu  Arg Ile Lys Thr Glu  Glu Gly Pro 
    1565                 1570                 1575             


Ser Pro  Ser Glu Ala His Gln  Gly Ala Glu Asp Pro  Phe Arg Pro 
    1580                 1585                 1590             


Ala Gly  Asn Leu Glu Gln Ala  Asn Glu Glu Leu Arg  Ala Ile Ile 
    1595                 1600                 1605             


Lys Lys  Ile Trp Lys Arg Thr  Ser Met Lys Leu Leu  Asp Gln Val 
    1610                 1615                 1620             


Val Pro  Pro Ala Gly Asp Asp  Glu Val Thr Val Gly  Lys Phe Tyr 
    1625                 1630                 1635             


Ala Thr  Phe Leu Ile Gln Glu  Tyr Phe Arg Lys Phe  Lys Lys Arg 
    1640                 1645                 1650             


Lys Glu  Gln Gly Leu Val Gly  Lys Pro Ser Gln Arg  Asn Ala Leu 
    1655                 1660                 1665             


Ser Leu  Gln Ala Gly Leu Arg  Thr Leu His Asp Ile  Gly Pro Glu 
    1670                 1675                 1680             


Ile Arg  Arg Ala Ile Ser Gly  Asp Leu Thr Ala Glu  Glu Glu Leu 
    1685                 1690                 1695             


Asp Lys  Ala Met Lys Glu Ala  Val Ser Ala Ala Ser  Glu Asp Asp 
    1700                 1705                 1710             


Ile Phe  Arg Arg Ala Gly Gly  Leu Phe Gly Asn His  Val Ser Tyr 
    1715                 1720                 1725             


Tyr Gln  Ser Asp Gly Arg Ser  Ala Phe Pro Gln Thr  Phe Thr Thr 
    1730                 1735                 1740             


Gln Arg  Pro Leu His Ile Asn  Lys Ala Gly Ser Ser  Gln Gly Asp 
    1745                 1750                 1755             


Thr Glu  Ser Pro Ser His Glu  Lys Leu Val Asp Ser  Thr Phe Thr 
    1760                 1765                 1770             


Pro Ser  Ser Tyr Ser Ser Thr  Gly Ser Asn Ala Asn  Ile Asn Asn 
    1775                 1780                 1785             


Ala Asn  Asn Thr Ala Leu Gly  Arg Leu Pro Arg Pro  Ala Gly Tyr 
    1790                 1795                 1800             


Pro Ser  Thr Val Ser Thr Val  Glu Gly His Gly Pro  Pro Leu Ser 
    1805                 1810                 1815             


Pro Ala  Ile Arg Val Gln Glu  Val Ala Trp Lys Leu  Ser Ser Asn 
    1820                 1825                 1830             


Arg Cys  His Ser Arg Glu Ser  Gln Ala Ala Met Ala  Gly Gln Glu 
    1835                 1840                 1845             


Glu Thr  Ser Gln Asp Glu Thr  Tyr Glu Val Lys Met  Asn His Asp 
    1850                 1855                 1860             


Thr Glu  Ala Cys Ser Glu Pro  Ser Leu Leu Ser Thr  Glu Met Leu 
    1865                 1870                 1875             


Ser Tyr  Gln Asp Asp Glu Asn  Arg Gln Leu Thr Leu  Pro Glu Glu 
    1880                 1885                 1890             


Asp Lys  Arg Asp Ile Arg Gln  Ser Pro Lys Arg Gly  Phe Leu Arg 
    1895                 1900                 1905             


Ser Ala  Ser Leu Gly Arg Arg  Ala Ser Phe His Leu  Glu Cys Leu 
    1910                 1915                 1920             


Lys Arg  Gln Lys Asp Arg Gly  Gly Asp Ile Ser Gln  Lys Thr Val 
    1925                 1930                 1935             


Leu Pro  Leu His Leu Val His  His Gln Ala Leu Ala  Val Ala Gly 
    1940                 1945                 1950             


Leu Ser  Pro Leu Leu Gln Arg  Ser His Ser Pro Ala  Ser Phe Pro 
    1955                 1960                 1965             


Arg Pro  Phe Ala Thr Pro Pro  Ala Thr Pro Gly Ser  Arg Gly Trp 
    1970                 1975                 1980             


Pro Pro  Gln Pro Val Pro Thr  Leu Arg Leu Glu Gly  Val Glu Ser 
    1985                 1990                 1995             


Ser Glu  Lys Leu Asn Ser Ser  Phe Pro Ser Ile His  Cys Gly Ser 
    2000                 2005                 2010             


Trp Ala  Glu Thr Thr Pro Gly  Gly Gly Gly Ser Ser  Ala Ala Arg 
    2015                 2020                 2025             


Arg Val  Arg Pro Val Ser Leu  Met Val Pro Ser Gln  Ala Gly Ala 
    2030                 2035                 2040             


Pro Gly  Arg Gln Phe His Gly  Ser Ala Ser Ser Leu  Val Glu Ala 
    2045                 2050                 2055             


Val Leu  Ile Ser Glu Gly Leu  Gly Gln Phe Ala Gln  Asp Pro Lys 
    2060                 2065                 2070             


Phe Ile  Glu Val Thr Thr Gln  Glu Leu Ala Asp Ala  Cys Asp Met 
    2075                 2080                 2085             


Thr Ile  Glu Glu Met Glu Ser  Ala Ala Asp Asn Ile  Leu Ser Gly 
    2090                 2095                 2100             


Gly Ala  Pro Gln Ser Pro Asn  Gly Ala Leu Leu Pro  Phe Val Asn 
    2105                 2110                 2115             


Cys Arg  Asp Ala Gly Gln Asp  Arg Ala Gly Gly Glu  Glu Asp Ala 
    2120                 2125                 2130             


Gly Cys  Val Arg Ala Arg Gly  Arg Pro Ser Glu Glu  Glu Leu Gln 
    2135                 2140                 2145             


Asp Ser  Arg Val Tyr Val Ser  Ser Leu 
    2150                 2155         


<210>  1390
<211>  2157
<212>  PRT
<213>  Homo sapiens

<400>  1390

Met Val Asn Glu Asn Thr Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser Thr Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Thr Thr 
                85                  90                  95      


Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Thr 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Thr Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Thr Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Thr Glu Val Gln Asp Thr Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Thr Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr Ile Leu Val Glu Thr 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Thr Arg Arg Ser Thr 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Thr Val Phe Gln Ile Leu Thr 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Thr Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Thr Thr Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Thr Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Thr Thr Ile Phe 
    930                 935                 940                 


Thr Ile Glu Ile Ala Leu Lys Met Thr Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Thr Ile Gly  Asn Ile Val Ile Val  Thr Thr Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Thr Cys Ser Asp  Ser Ser Lys Gln Thr  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Thr  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Thr  Val Ser Thr 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Thr Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Thr Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Thr Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Thr 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Thr Gly  Leu Phe Thr 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys His Tyr 
    1265                 1270                 1275             


Phe Cys  Asp Ala Trp Asn Thr  Phe Asp Ala Leu Ile  Val Val Gly 
    1280                 1285                 1290             


Ser Ile  Val Asp Ile Ala Ile  Thr Glu Val Asn Pro  Ala Glu His 
    1295                 1300                 1305             


Thr Gln  Cys Ser Pro Ser Met  Asn Ala Glu Glu Asn  Ser Arg Ile 
    1310                 1315                 1320             


Ser Ile  Thr Phe Phe Arg Leu  Phe Arg Val Met Arg  Leu Val Lys 
    1325                 1330                 1335             


Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Thr Leu Leu  Trp Thr Phe 
    1340                 1345                 1350             


Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Val 
    1355                 1360                 1365             


Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly Met Gln  Val Phe Gly 
    1370                 1375                 1380             


Lys Ile  Ala Leu Asn Asp Thr  Thr Glu Ile Asn Arg  Asn Asn Asn 
    1385                 1390                 1395             


Phe Gln  Thr Phe Pro Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala 
    1400                 1405                 1410             


Thr Gly  Glu Ala Trp Gln Asp  Ile Met Leu Ala Cys  Met Pro Gly 
    1415                 1420                 1425             


Lys Lys  Cys Ala Pro Glu Ser  Glu Pro Ser Asn Ser  Thr Glu Gly 
    1430                 1435                 1440             


Glu Thr  Pro Cys Gly Ser Ser  Phe Ala Val Phe Tyr  Phe Ile Ser 
    1445                 1450                 1455             


Phe Tyr  Met Leu Cys Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala 
    1460                 1465                 1470             


Val Ile  Met Asp Asn Phe Asp  Tyr Leu Thr Arg Asp  Trp Ser Ile 
    1475                 1480                 1485             


Leu Gly  Pro His His Leu Asp  Glu Phe Lys Arg Ile  Trp Ala Glu 
    1490                 1495                 1500             


Tyr Asp  Pro Glu Ala Lys Gly  Arg Ile Lys His Leu  Asp Val Val 
    1505                 1510                 1515             


Thr Leu  Leu Arg Arg Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu 
    1520                 1525                 1530             


Cys Pro  His Arg Val Ala Cys  Lys Arg Leu Val Ser  Met Asn Met 
    1535                 1540                 1545             


Pro Leu  Asn Ser Asp Gly Thr  Val Met Phe Asn Ala  Thr Leu Phe 
    1550                 1555                 1560             


Ala Leu  Val Arg Thr Ala Leu  Arg Ile Lys Thr Glu  Glu Gly Pro 
    1565                 1570                 1575             


Ser Pro  Ser Glu Ala His Gln  Gly Ala Glu Asp Pro  Phe Arg Pro 
    1580                 1585                 1590             


Ala Gly  Asn Leu Glu Gln Ala  Asn Glu Glu Leu Arg  Ala Ile Ile 
    1595                 1600                 1605             


Lys Lys  Ile Trp Lys Arg Thr  Ser Met Lys Leu Leu  Asp Gln Val 
    1610                 1615                 1620             


Val Pro  Pro Ala Gly Asp Asp  Glu Val Thr Val Gly  Lys Phe Tyr 
    1625                 1630                 1635             


Ala Thr  Phe Leu Ile Gln Glu  Tyr Phe Arg Lys Phe  Lys Lys Arg 
    1640                 1645                 1650             


Lys Glu  Gln Gly Leu Val Gly  Lys Pro Ser Gln Arg  Asn Ala Leu 
    1655                 1660                 1665             


Ser Leu  Gln Ala Gly Leu Arg  Thr Leu His Asp Ile  Gly Pro Glu 
    1670                 1675                 1680             


Ile Arg  Arg Ala Ile Ser Gly  Asp Leu Thr Ala Glu  Glu Glu Leu 
    1685                 1690                 1695             


Asp Lys  Ala Met Lys Glu Ala  Val Ser Ala Ala Ser  Glu Asp Asp 
    1700                 1705                 1710             


Ile Phe  Arg Arg Ala Gly Gly  Leu Phe Gly Asn His  Val Ser Tyr 
    1715                 1720                 1725             


Tyr Gln  Ser Asp Gly Arg Ser  Ala Phe Pro Gln Thr  Phe Thr Thr 
    1730                 1735                 1740             


Gln Arg  Pro Leu His Ile Asn  Lys Ala Gly Ser Ser  Gln Gly Asp 
    1745                 1750                 1755             


Thr Glu  Ser Pro Ser His Glu  Lys Leu Val Asp Ser  Thr Phe Thr 
    1760                 1765                 1770             


Pro Ser  Ser Tyr Ser Ser Thr  Gly Ser Asn Ala Asn  Ile Asn Asn 
    1775                 1780                 1785             


Ala Asn  Asn Thr Ala Leu Gly  Arg Leu Pro Arg Pro  Ala Gly Tyr 
    1790                 1795                 1800             


Pro Ser  Thr Val Ser Thr Val  Glu Gly His Gly Pro  Pro Leu Ser 
    1805                 1810                 1815             


Pro Ala  Ile Arg Val Gln Glu  Val Ala Trp Lys Leu  Ser Ser Asn 
    1820                 1825                 1830             


Arg Cys  His Ser Arg Glu Ser  Gln Ala Ala Met Ala  Gly Gln Glu 
    1835                 1840                 1845             


Glu Thr  Ser Gln Asp Glu Thr  Tyr Glu Val Lys Met  Asn His Asp 
    1850                 1855                 1860             


Thr Glu  Ala Cys Ser Glu Pro  Ser Leu Leu Ser Thr  Glu Met Leu 
    1865                 1870                 1875             


Ser Tyr  Gln Asp Asp Glu Asn  Arg Gln Leu Thr Leu  Pro Glu Glu 
    1880                 1885                 1890             


Asp Lys  Arg Asp Ile Arg Gln  Ser Pro Lys Arg Gly  Phe Leu Arg 
    1895                 1900                 1905             


Ser Ala  Ser Leu Gly Arg Arg  Ala Ser Phe His Leu  Glu Cys Leu 
    1910                 1915                 1920             


Lys Arg  Gln Lys Asp Arg Gly  Gly Asp Ile Ser Gln  Lys Thr Val 
    1925                 1930                 1935             


Leu Pro  Leu His Leu Val His  His Gln Ala Leu Ala  Val Ala Gly 
    1940                 1945                 1950             


Leu Ser  Pro Leu Leu Gln Arg  Ser His Ser Pro Ala  Ser Phe Pro 
    1955                 1960                 1965             


Arg Pro  Phe Ala Thr Pro Pro  Ala Thr Pro Gly Ser  Arg Gly Trp 
    1970                 1975                 1980             


Pro Pro  Gln Pro Val Pro Thr  Leu Arg Leu Glu Gly  Val Glu Ser 
    1985                 1990                 1995             


Ser Glu  Lys Leu Asn Ser Ser  Phe Pro Ser Ile His  Cys Gly Ser 
    2000                 2005                 2010             


Trp Ala  Glu Thr Thr Pro Gly  Gly Gly Gly Ser Ser  Ala Ala Arg 
    2015                 2020                 2025             


Arg Val  Arg Pro Val Ser Leu  Met Val Pro Ser Gln  Ala Gly Ala 
    2030                 2035                 2040             


Pro Gly  Arg Gln Phe His Gly  Ser Ala Ser Ser Leu  Val Glu Ala 
    2045                 2050                 2055             


Val Leu  Ile Ser Glu Gly Leu  Gly Gln Phe Ala Gln  Asp Pro Lys 
    2060                 2065                 2070             


Phe Ile  Glu Val Thr Thr Gln  Glu Leu Ala Asp Ala  Cys Asp Met 
    2075                 2080                 2085             


Thr Ile  Glu Glu Met Glu Ser  Ala Ala Asp Asn Ile  Leu Ser Gly 
    2090                 2095                 2100             


Gly Ala  Pro Gln Ser Pro Asn  Gly Ala Leu Leu Pro  Phe Val Asn 
    2105                 2110                 2115             


Cys Arg  Asp Ala Gly Gln Asp  Arg Ala Gly Gly Glu  Glu Asp Ala 
    2120                 2125                 2130             


Gly Cys  Val Arg Ala Arg Gly  Arg Pro Ser Glu Glu  Glu Leu Gln 
    2135                 2140                 2145             


Asp Ser  Arg Val Tyr Val Ser  Ser Leu 
    2150                 2155         


<210>  1391
<211>  2157
<212>  PRT
<213>  Homo sapiens

<400>  1391

Met Val Asn Glu Asn Thr Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser Thr Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Thr Thr 
                85                  90                  95      


Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Thr 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Thr Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Thr Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Thr Glu Val Gln Asp Thr Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Thr Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr Ile Leu Val Glu Thr 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Thr Arg Arg Ser Thr 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Thr Val Phe Gln Ile Leu Thr 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Thr Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Thr Thr Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Thr Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Gly Asn Ala Asp Tyr Val Phe Thr Ser Ile Phe 
    930                 935                 940                 


Thr Leu Glu Ile Ile Leu Lys Met Thr Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Thr Ile Gly  Asn Ile Val Ile Val  Thr Thr Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Thr Cys Ser Asp  Ser Ser Lys Gln Thr  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Thr  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Thr  Val Ser Thr 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Thr Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Thr Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Thr Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Thr 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Thr Gly  Leu Phe Thr 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys His Tyr 
    1265                 1270                 1275             


Phe Cys  Asp Ala Trp Asn Thr  Phe Asp Ala Leu Ile  Val Val Gly 
    1280                 1285                 1290             


Ser Ile  Val Asp Ile Ala Ile  Thr Glu Val Asn Pro  Ala Glu His 
    1295                 1300                 1305             


Thr Gln  Cys Ser Pro Ser Met  Asn Ala Glu Glu Asn  Ser Arg Ile 
    1310                 1315                 1320             


Ser Ile  Thr Phe Phe Arg Leu  Phe Arg Val Met Arg  Leu Val Lys 
    1325                 1330                 1335             


Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Thr Leu Leu  Trp Thr Phe 
    1340                 1345                 1350             


Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Val 
    1355                 1360                 1365             


Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly Met Gln  Val Phe Gly 
    1370                 1375                 1380             


Lys Ile  Ala Leu Asn Asp Thr  Thr Glu Ile Asn Arg  Asn Asn Asn 
    1385                 1390                 1395             


Phe Gln  Thr Phe Pro Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala 
    1400                 1405                 1410             


Thr Gly  Glu Ala Trp Gln Asp  Ile Met Leu Ala Cys  Met Pro Gly 
    1415                 1420                 1425             


Lys Lys  Cys Ala Pro Glu Ser  Glu Pro Ser Asn Ser  Thr Glu Gly 
    1430                 1435                 1440             


Glu Thr  Pro Cys Gly Ser Ser  Phe Ala Val Phe Tyr  Phe Ile Ser 
    1445                 1450                 1455             


Phe Tyr  Met Leu Cys Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala 
    1460                 1465                 1470             


Val Ile  Met Asp Asn Phe Asp  Tyr Leu Thr Arg Asp  Trp Ser Ile 
    1475                 1480                 1485             


Leu Gly  Pro His His Leu Asp  Glu Phe Lys Arg Ile  Trp Ala Glu 
    1490                 1495                 1500             


Tyr Asp  Pro Glu Ala Lys Gly  Arg Ile Lys His Leu  Asp Val Val 
    1505                 1510                 1515             


Thr Leu  Leu Arg Arg Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu 
    1520                 1525                 1530             


Cys Pro  His Arg Val Ala Cys  Lys Arg Leu Val Ser  Met Asn Met 
    1535                 1540                 1545             


Pro Leu  Asn Ser Asp Gly Thr  Val Met Phe Asn Ala  Thr Leu Phe 
    1550                 1555                 1560             


Ala Leu  Val Arg Thr Ala Leu  Arg Ile Lys Thr Glu  Glu Gly Pro 
    1565                 1570                 1575             


Ser Pro  Ser Glu Ala His Gln  Gly Ala Glu Asp Pro  Phe Arg Pro 
    1580                 1585                 1590             


Ala Gly  Asn Leu Glu Gln Ala  Asn Glu Glu Leu Arg  Ala Ile Ile 
    1595                 1600                 1605             


Lys Lys  Ile Trp Lys Arg Thr  Ser Met Lys Leu Leu  Asp Gln Val 
    1610                 1615                 1620             


Val Pro  Pro Ala Gly Asp Asp  Glu Val Thr Val Gly  Lys Phe Tyr 
    1625                 1630                 1635             


Ala Thr  Phe Leu Ile Gln Glu  Tyr Phe Arg Lys Phe  Lys Lys Arg 
    1640                 1645                 1650             


Lys Glu  Gln Gly Leu Val Gly  Lys Pro Ser Gln Arg  Asn Ala Leu 
    1655                 1660                 1665             


Ser Leu  Gln Ala Gly Leu Arg  Thr Leu His Asp Ile  Gly Pro Glu 
    1670                 1675                 1680             


Ile Arg  Arg Ala Ile Ser Gly  Asp Leu Thr Ala Glu  Glu Glu Leu 
    1685                 1690                 1695             


Asp Lys  Ala Met Lys Glu Ala  Val Ser Ala Ala Ser  Glu Asp Asp 
    1700                 1705                 1710             


Ile Phe  Arg Arg Ala Gly Gly  Leu Phe Gly Asn His  Val Ser Tyr 
    1715                 1720                 1725             


Tyr Gln  Ser Asp Gly Arg Ser  Ala Phe Pro Gln Thr  Phe Thr Thr 
    1730                 1735                 1740             


Gln Arg  Pro Leu His Ile Asn  Lys Ala Gly Ser Ser  Gln Gly Asp 
    1745                 1750                 1755             


Thr Glu  Ser Pro Ser His Glu  Lys Leu Val Asp Ser  Thr Phe Thr 
    1760                 1765                 1770             


Pro Ser  Ser Tyr Ser Ser Thr  Gly Ser Asn Ala Asn  Ile Asn Asn 
    1775                 1780                 1785             


Ala Asn  Asn Thr Ala Leu Gly  Arg Leu Pro Arg Pro  Ala Gly Tyr 
    1790                 1795                 1800             


Pro Ser  Thr Val Ser Thr Val  Glu Gly His Gly Pro  Pro Leu Ser 
    1805                 1810                 1815             


Pro Ala  Ile Arg Val Gln Glu  Val Ala Trp Lys Leu  Ser Ser Asn 
    1820                 1825                 1830             


Arg Cys  His Ser Arg Glu Ser  Gln Ala Ala Met Ala  Gly Gln Glu 
    1835                 1840                 1845             


Glu Thr  Ser Gln Asp Glu Thr  Tyr Glu Val Lys Met  Asn His Asp 
    1850                 1855                 1860             


Thr Glu  Ala Cys Ser Glu Pro  Ser Leu Leu Ser Thr  Glu Met Leu 
    1865                 1870                 1875             


Ser Tyr  Gln Asp Asp Glu Asn  Arg Gln Leu Thr Leu  Pro Glu Glu 
    1880                 1885                 1890             


Asp Lys  Arg Asp Ile Arg Gln  Ser Pro Lys Arg Gly  Phe Leu Arg 
    1895                 1900                 1905             


Ser Ala  Ser Leu Gly Arg Arg  Ala Ser Phe His Leu  Glu Cys Leu 
    1910                 1915                 1920             


Lys Arg  Gln Lys Asp Arg Gly  Gly Asp Ile Ser Gln  Lys Thr Val 
    1925                 1930                 1935             


Leu Pro  Leu His Leu Val His  His Gln Ala Leu Ala  Val Ala Gly 
    1940                 1945                 1950             


Leu Ser  Pro Leu Leu Gln Arg  Ser His Ser Pro Ala  Ser Phe Pro 
    1955                 1960                 1965             


Arg Pro  Phe Ala Thr Pro Pro  Ala Thr Pro Gly Ser  Arg Gly Trp 
    1970                 1975                 1980             


Pro Pro  Gln Pro Val Pro Thr  Leu Arg Leu Glu Gly  Val Glu Ser 
    1985                 1990                 1995             


Ser Glu  Lys Leu Asn Ser Ser  Phe Pro Ser Ile His  Cys Gly Ser 
    2000                 2005                 2010             


Trp Ala  Glu Thr Thr Pro Gly  Gly Gly Gly Ser Ser  Ala Ala Arg 
    2015                 2020                 2025             


Arg Val  Arg Pro Val Ser Leu  Met Val Pro Ser Gln  Ala Gly Ala 
    2030                 2035                 2040             


Pro Gly  Arg Gln Phe His Gly  Ser Ala Ser Ser Leu  Val Glu Ala 
    2045                 2050                 2055             


Val Leu  Ile Ser Glu Gly Leu  Gly Gln Phe Ala Gln  Asp Pro Lys 
    2060                 2065                 2070             


Phe Ile  Glu Val Thr Thr Gln  Glu Leu Ala Asp Ala  Cys Asp Met 
    2075                 2080                 2085             


Thr Ile  Glu Glu Met Glu Ser  Ala Ala Asp Asn Ile  Leu Ser Gly 
    2090                 2095                 2100             


Gly Ala  Pro Gln Ser Pro Asn  Gly Ala Leu Leu Pro  Phe Val Asn 
    2105                 2110                 2115             


Cys Arg  Asp Ala Gly Gln Asp  Arg Ala Gly Gly Glu  Glu Asp Ala 
    2120                 2125                 2130             


Gly Cys  Val Arg Ala Arg Gly  Arg Pro Ser Glu Glu  Glu Leu Gln 
    2135                 2140                 2145             


Asp Ser  Arg Val Tyr Val Ser  Ser Leu 
    2150                 2155         


<210>  1392
<211>  2155
<212>  PRT
<213>  Homo sapiens

<400>  1392

Met Val Asn Glu Asn Thr Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser Thr Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Thr Thr 
                85                  90                  95      


Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Thr 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Thr Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Thr Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Thr Glu Val Gln Asp Thr Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Thr Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr Ile Leu Val Glu Thr 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Thr Arg Arg Ser Thr 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Thr Val Phe Gln Ile Leu Thr 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Thr Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Thr Thr Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Thr Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Gly Asn Ala Asp Tyr Val Phe Thr Ser Ile Phe 
    930                 935                 940                 


Thr Leu Glu Ile Ile Leu Lys Met Thr Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Thr Ile Gly  Asn Ile Val Ile Val  Thr Thr Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Thr Cys Ser Asp  Ser Ser Lys Gln Thr  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Thr  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Thr  Val Ser Thr 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Thr Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Thr Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Thr Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Thr 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Thr Gly  Leu Phe Thr 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys Gly Tyr 
    1265                 1270                 1275             


Phe Ser  Asp Pro Trp Asn Val  Phe Asp Phe Leu Ile  Val Ile Gly 
    1280                 1285                 1290             


Ser Ile  Ile Asp Val Ile Leu  Ser Glu Thr Asn His  Tyr Phe Cys 
    1295                 1300                 1305             


Asp Ala  Trp Asn Thr Phe Asp  Ala Leu Ile Val Val  Gly Ser Ile 
    1310                 1315                 1320             


Val Asp  Ile Ala Ile Thr Glu  Val Asn Asn Ala Glu  Glu Asn Ser 
    1325                 1330                 1335             


Arg Ile  Ser Ile Thr Phe Phe  Arg Leu Phe Arg Val  Met Arg Leu 
    1340                 1345                 1350             


Val Lys  Leu Leu Ser Arg Gly  Glu Gly Ile Arg Thr  Leu Leu Trp 
    1355                 1360                 1365             


Thr Phe  Ile Lys Ser Phe Gln  Ala Leu Pro Tyr Val  Ala Leu Leu 
    1370                 1375                 1380             


Ile Val  Met Leu Phe Phe Ile  Tyr Ala Val Ile Gly  Met Gln Val 
    1385                 1390                 1395             


Phe Gly  Lys Ile Ala Leu Asn  Asp Thr Thr Glu Ile  Asn Arg Asn 
    1400                 1405                 1410             


Asn Asn  Phe Gln Thr Phe Pro  Gln Ala Val Leu Leu  Leu Phe Arg 
    1415                 1420                 1425             


Cys Ala  Thr Gly Glu Ala Trp  Gln Asp Ile Met Leu  Ala Cys Met 
    1430                 1435                 1440             


Pro Gly  Lys Lys Cys Ala Pro  Glu Ser Glu Pro Ser  Asn Ser Thr 
    1445                 1450                 1455             


Glu Gly  Glu Thr Pro Cys Gly  Ser Ser Phe Ala Val  Phe Tyr Phe 
    1460                 1465                 1470             


Ile Ser  Phe Tyr Met Leu Cys  Ala Phe Leu Ile Ile  Asn Leu Phe 
    1475                 1480                 1485             


Val Ala  Val Ile Met Asp Asn  Phe Asp Tyr Leu Thr  Arg Asp Trp 
    1490                 1495                 1500             


Ser Ile  Leu Gly Pro His His  Leu Asp Glu Phe Lys  Arg Ile Trp 
    1505                 1510                 1515             


Ala Glu  Tyr Asp Pro Glu Ala  Lys Gly Arg Ile Lys  His Leu Asp 
    1520                 1525                 1530             


Val Val  Thr Leu Leu Arg Arg  Ile Gln Pro Pro Leu  Gly Phe Gly 
    1535                 1540                 1545             


Lys Leu  Cys Pro His Arg Val  Ala Cys Lys Arg Leu  Val Ser Met 
    1550                 1555                 1560             


Asn Met  Pro Leu Asn Ser Asp  Gly Thr Val Met Phe  Asn Ala Thr 
    1565                 1570                 1575             


Leu Phe  Ala Leu Val Arg Thr  Ala Leu Arg Ile Lys  Thr Glu Gly 
    1580                 1585                 1590             


Asn Leu  Glu Gln Ala Asn Glu  Glu Leu Arg Ala Ile  Ile Lys Lys 
    1595                 1600                 1605             


Ile Trp  Lys Arg Thr Ser Met  Lys Leu Leu Asp Gln  Val Val Pro 
    1610                 1615                 1620             


Pro Ala  Gly Asp Asp Glu Val  Thr Val Gly Lys Phe  Tyr Ala Thr 
    1625                 1630                 1635             


Phe Leu  Ile Gln Glu Tyr Phe  Arg Lys Phe Lys Lys  Arg Lys Glu 
    1640                 1645                 1650             


Gln Gly  Leu Val Gly Lys Pro  Ser Gln Arg Asn Ala  Leu Ser Leu 
    1655                 1660                 1665             


Gln Ala  Gly Leu Arg Thr Leu  His Asp Ile Gly Pro  Glu Ile Arg 
    1670                 1675                 1680             


Arg Ala  Ile Ser Gly Asp Leu  Thr Ala Glu Glu Glu  Leu Asp Lys 
    1685                 1690                 1695             


Ala Met  Lys Glu Ala Val Ser  Ala Ala Ser Glu Asp  Asp Ile Phe 
    1700                 1705                 1710             


Arg Arg  Ala Gly Gly Leu Phe  Gly Asn His Val Ser  Tyr Tyr Gln 
    1715                 1720                 1725             


Ser Asp  Gly Arg Ser Ala Phe  Pro Gln Thr Phe Thr  Thr Gln Arg 
    1730                 1735                 1740             


Pro Leu  His Ile Asn Lys Ala  Gly Ser Ser Gln Gly  Asp Thr Glu 
    1745                 1750                 1755             


Ser Pro  Ser His Glu Lys Leu  Val Asp Ser Thr Phe  Thr Pro Ser 
    1760                 1765                 1770             


Ser Tyr  Ser Ser Thr Gly Ser  Asn Ala Asn Ile Asn  Asn Ala Asn 
    1775                 1780                 1785             


Asn Thr  Ala Leu Gly Arg Leu  Pro Arg Pro Ala Gly  Tyr Pro Ser 
    1790                 1795                 1800             


Thr Val  Ser Thr Val Glu Gly  His Gly Pro Pro Leu  Ser Pro Ala 
    1805                 1810                 1815             


Ile Arg  Val Gln Glu Val Ala  Trp Lys Leu Ser Ser  Asn Arg Cys 
    1820                 1825                 1830             


His Ser  Arg Glu Ser Gln Ala  Ala Met Ala Gly Gln  Glu Glu Thr 
    1835                 1840                 1845             


Ser Gln  Asp Glu Thr Tyr Glu  Val Lys Met Asn His  Asp Thr Glu 
    1850                 1855                 1860             


Ala Cys  Ser Glu Pro Ser Leu  Leu Ser Thr Glu Met  Leu Ser Tyr 
    1865                 1870                 1875             


Gln Asp  Asp Glu Asn Arg Gln  Leu Thr Leu Pro Glu  Glu Asp Lys 
    1880                 1885                 1890             


Arg Asp  Ile Arg Gln Ser Pro  Lys Arg Gly Phe Leu  Arg Ser Ala 
    1895                 1900                 1905             


Ser Leu  Gly Arg Arg Ala Ser  Phe His Leu Glu Cys  Leu Lys Arg 
    1910                 1915                 1920             


Gln Lys  Asp Arg Gly Gly Asp  Ile Ser Gln Lys Thr  Val Leu Pro 
    1925                 1930                 1935             


Leu His  Leu Val His His Gln  Ala Leu Ala Val Ala  Gly Leu Ser 
    1940                 1945                 1950             


Pro Leu  Leu Gln Arg Ser His  Ser Pro Ala Ser Phe  Pro Arg Pro 
    1955                 1960                 1965             


Phe Ala  Thr Pro Pro Ala Thr  Pro Gly Ser Arg Gly  Trp Pro Pro 
    1970                 1975                 1980             


Gln Pro  Val Pro Thr Leu Arg  Leu Glu Gly Val Glu  Ser Ser Glu 
    1985                 1990                 1995             


Lys Leu  Asn Ser Ser Phe Pro  Ser Ile His Cys Gly  Ser Trp Ala 
    2000                 2005                 2010             


Glu Thr  Thr Pro Gly Gly Gly  Gly Ser Ser Ala Ala  Arg Arg Val 
    2015                 2020                 2025             


Arg Pro  Val Ser Leu Met Val  Pro Ser Gln Ala Gly  Ala Pro Gly 
    2030                 2035                 2040             


Arg Gln  Phe His Gly Ser Ala  Ser Ser Leu Val Glu  Ala Val Leu 
    2045                 2050                 2055             


Ile Ser  Glu Gly Leu Gly Gln  Phe Ala Gln Asp Pro  Lys Phe Ile 
    2060                 2065                 2070             


Glu Val  Thr Thr Gln Glu Leu  Ala Asp Ala Cys Asp  Met Thr Ile 
    2075                 2080                 2085             


Glu Glu  Met Glu Ser Ala Ala  Asp Asn Ile Leu Ser  Gly Gly Ala 
    2090                 2095                 2100             


Pro Gln  Ser Pro Asn Gly Ala  Leu Leu Pro Phe Val  Asn Cys Arg 
    2105                 2110                 2115             


Asp Ala  Gly Gln Asp Arg Ala  Gly Gly Glu Glu Asp  Ala Gly Cys 
    2120                 2125                 2130             


Val Arg  Ala Arg Gly Arg Pro  Ser Glu Glu Glu Leu  Gln Asp Ser 
    2135                 2140                 2145             


Arg Val  Tyr Val Ser Ser Leu  
    2150                 2155 


<210>  1393
<211>  2146
<212>  PRT
<213>  Homo sapiens

<400>  1393

Met Val Asn Glu Asn Thr Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser Thr Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Thr Thr 
                85                  90                  95      


Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Thr 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Thr Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Thr Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Thr Glu Val Gln Asp Thr Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Thr Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr Ile Leu Val Glu Thr 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Thr Arg Arg Ser Thr 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Thr Val Phe Gln Ile Leu Thr 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Thr Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Thr Thr Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Thr Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Thr Thr Ile Phe 
    930                 935                 940                 


Thr Ile Glu Ile Ala Leu Lys Met Thr Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Thr Ile Gly  Asn Ile Val Ile Val  Thr Thr Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Thr Cys Ser Asp  Ser Ser Lys Gln Thr  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Thr  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Thr  Val Ser Thr 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Thr Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Thr Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Thr Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Thr 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Thr Gly  Leu Phe Thr 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys His Tyr 
    1265                 1270                 1275             


Phe Cys  Asp Ala Trp Asn Thr  Phe Asp Ala Leu Ile  Val Val Gly 
    1280                 1285                 1290             


Ser Ile  Val Asp Ile Ala Ile  Thr Glu Val Asn Asn  Ala Glu Glu 
    1295                 1300                 1305             


Asn Ser  Arg Ile Ser Ile Thr  Phe Phe Arg Leu Phe  Arg Val Met 
    1310                 1315                 1320             


Arg Leu  Val Lys Leu Leu Ser  Arg Gly Glu Gly Ile  Arg Thr Leu 
    1325                 1330                 1335             


Leu Trp  Thr Phe Ile Lys Ser  Phe Gln Ala Leu Pro  Tyr Val Ala 
    1340                 1345                 1350             


Leu Leu  Ile Val Met Leu Phe  Phe Ile Tyr Ala Val  Ile Gly Met 
    1355                 1360                 1365             


Gln Val  Phe Gly Lys Ile Ala  Leu Asn Asp Thr Thr  Glu Ile Asn 
    1370                 1375                 1380             


Arg Asn  Asn Asn Phe Gln Thr  Phe Pro Gln Ala Val  Leu Leu Leu 
    1385                 1390                 1395             


Phe Arg  Cys Ala Thr Gly Glu  Ala Trp Gln Asp Ile  Met Leu Ala 
    1400                 1405                 1410             


Cys Met  Pro Gly Lys Lys Cys  Ala Pro Glu Ser Glu  Pro Ser Asn 
    1415                 1420                 1425             


Ser Thr  Glu Gly Glu Thr Pro  Cys Gly Ser Ser Phe  Ala Val Phe 
    1430                 1435                 1440             


Tyr Phe  Ile Ser Phe Tyr Met  Leu Cys Ala Phe Leu  Ile Ile Asn 
    1445                 1450                 1455             


Leu Phe  Val Ala Val Ile Met  Asp Asn Phe Asp Tyr  Leu Thr Arg 
    1460                 1465                 1470             


Asp Trp  Ser Ile Leu Gly Pro  His His Leu Asp Glu  Phe Lys Arg 
    1475                 1480                 1485             


Ile Trp  Ala Glu Tyr Asp Pro  Glu Ala Lys Gly Arg  Ile Lys His 
    1490                 1495                 1500             


Leu Asp  Val Val Thr Leu Leu  Arg Arg Ile Gln Pro  Pro Leu Gly 
    1505                 1510                 1515             


Phe Gly  Lys Leu Cys Pro His  Arg Val Ala Cys Lys  Arg Leu Val 
    1520                 1525                 1530             


Ser Met  Asn Met Pro Leu Asn  Ser Asp Gly Thr Val  Met Phe Asn 
    1535                 1540                 1545             


Ala Thr  Leu Phe Ala Leu Val  Arg Thr Ala Leu Arg  Ile Lys Thr 
    1550                 1555                 1560             


Glu Glu  Gly Pro Ser Pro Ser  Glu Ala His Gln Gly  Ala Glu Asp 
    1565                 1570                 1575             


Pro Phe  Arg Pro Ala Gly Asn  Leu Glu Gln Ala Asn  Glu Glu Leu 
    1580                 1585                 1590             


Arg Ala  Ile Ile Lys Lys Ile  Trp Lys Arg Thr Ser  Met Lys Leu 
    1595                 1600                 1605             


Leu Asp  Gln Val Val Pro Pro  Ala Gly Asp Asp Glu  Val Thr Val 
    1610                 1615                 1620             


Gly Lys  Phe Tyr Ala Thr Phe  Leu Ile Gln Glu Tyr  Phe Arg Lys 
    1625                 1630                 1635             


Phe Lys  Lys Arg Lys Glu Gln  Gly Leu Val Gly Lys  Pro Ser Gln 
    1640                 1645                 1650             


Arg Asn  Ala Leu Ser Leu Gln  Ala Gly Leu Arg Thr  Leu His Asp 
    1655                 1660                 1665             


Ile Gly  Pro Glu Ile Arg Arg  Ala Ile Ser Gly Asp  Leu Thr Ala 
    1670                 1675                 1680             


Glu Glu  Glu Leu Asp Lys Ala  Met Lys Glu Ala Val  Ser Ala Ala 
    1685                 1690                 1695             


Ser Glu  Asp Asp Ile Phe Arg  Arg Ala Gly Gly Leu  Phe Gly Asn 
    1700                 1705                 1710             


His Val  Ser Tyr Tyr Gln Ser  Asp Gly Arg Ser Ala  Phe Pro Gln 
    1715                 1720                 1725             


Thr Phe  Thr Thr Gln Arg Pro  Leu His Ile Asn Lys  Ala Gly Ser 
    1730                 1735                 1740             


Ser Gln  Gly Asp Thr Glu Ser  Pro Ser His Glu Lys  Leu Val Asp 
    1745                 1750                 1755             


Ser Thr  Phe Thr Pro Ser Ser  Tyr Ser Ser Thr Gly  Ser Asn Ala 
    1760                 1765                 1770             


Asn Ile  Asn Asn Ala Asn Asn  Thr Ala Leu Gly Arg  Leu Pro Arg 
    1775                 1780                 1785             


Pro Ala  Gly Tyr Pro Ser Thr  Val Ser Thr Val Glu  Gly His Gly 
    1790                 1795                 1800             


Pro Pro  Leu Ser Pro Ala Ile  Arg Val Gln Glu Val  Ala Trp Lys 
    1805                 1810                 1815             


Leu Ser  Ser Asn Arg Cys His  Ser Arg Glu Ser Gln  Ala Ala Met 
    1820                 1825                 1830             


Ala Gly  Gln Glu Glu Thr Ser  Gln Asp Glu Thr Tyr  Glu Val Lys 
    1835                 1840                 1845             


Met Asn  His Asp Thr Glu Ala  Cys Ser Glu Pro Ser  Leu Leu Ser 
    1850                 1855                 1860             


Thr Glu  Met Leu Ser Tyr Gln  Asp Asp Glu Asn Arg  Gln Leu Thr 
    1865                 1870                 1875             


Leu Pro  Glu Glu Asp Lys Arg  Asp Ile Arg Gln Ser  Pro Lys Arg 
    1880                 1885                 1890             


Gly Phe  Leu Arg Ser Ala Ser  Leu Gly Arg Arg Ala  Ser Phe His 
    1895                 1900                 1905             


Leu Glu  Cys Leu Lys Arg Gln  Lys Asp Arg Gly Gly  Asp Ile Ser 
    1910                 1915                 1920             


Gln Lys  Thr Val Leu Pro Leu  His Leu Val His His  Gln Ala Leu 
    1925                 1930                 1935             


Ala Val  Ala Gly Leu Ser Pro  Leu Leu Gln Arg Ser  His Ser Pro 
    1940                 1945                 1950             


Ala Ser  Phe Pro Arg Pro Phe  Ala Thr Pro Pro Ala  Thr Pro Gly 
    1955                 1960                 1965             


Ser Arg  Gly Trp Pro Pro Gln  Pro Val Pro Thr Leu  Arg Leu Glu 
    1970                 1975                 1980             


Gly Val  Glu Ser Ser Glu Lys  Leu Asn Ser Ser Phe  Pro Ser Ile 
    1985                 1990                 1995             


His Cys  Gly Ser Trp Ala Glu  Thr Thr Pro Gly Gly  Gly Gly Ser 
    2000                 2005                 2010             


Ser Ala  Ala Arg Arg Val Arg  Pro Val Ser Leu Met  Val Pro Ser 
    2015                 2020                 2025             


Gln Ala  Gly Ala Pro Gly Arg  Gln Phe His Gly Ser  Ala Ser Ser 
    2030                 2035                 2040             


Leu Val  Glu Ala Val Leu Ile  Ser Glu Gly Leu Gly  Gln Phe Ala 
    2045                 2050                 2055             


Gln Asp  Pro Lys Phe Ile Glu  Val Thr Thr Gln Glu  Leu Ala Asp 
    2060                 2065                 2070             


Ala Cys  Asp Met Thr Ile Glu  Glu Met Glu Ser Ala  Ala Asp Asn 
    2075                 2080                 2085             


Ile Leu  Ser Gly Gly Ala Pro  Gln Ser Pro Asn Gly  Ala Leu Leu 
    2090                 2095                 2100             


Pro Phe  Val Asn Cys Arg Asp  Ala Gly Gln Asp Arg  Ala Gly Gly 
    2105                 2110                 2115             


Glu Glu  Asp Ala Gly Cys Val  Arg Ala Arg Gly Arg  Pro Ser Glu 
    2120                 2125                 2130             


Glu Glu  Leu Gln Asp Ser Arg  Val Tyr Val Ser Ser  Leu 
    2135                 2140                 2145     


<210>  1394
<211>  2146
<212>  PRT
<213>  Homo sapiens

<400>  1394

Met Val Asn Glu Asn Thr Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser Thr Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Thr Thr 
                85                  90                  95      


Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Thr 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Thr Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Thr Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Thr Glu Val Gln Asp Thr Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Thr Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr Ile Leu Val Glu Thr 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Thr Arg Arg Ser Thr 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Thr Val Phe Gln Ile Leu Thr 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Thr Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Thr Thr Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Thr Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Gly Asn Ala Asp Tyr Val Phe Thr Ser Ile Phe 
    930                 935                 940                 


Thr Leu Glu Ile Ile Leu Lys Met Thr Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Thr Ile Gly  Asn Ile Val Ile Val  Thr Thr Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Thr Cys Ser Asp  Ser Ser Lys Gln Thr  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Thr  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Thr  Val Ser Thr 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Thr Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Thr Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Thr Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Thr 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Thr Gly  Leu Phe Thr 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys His Tyr 
    1265                 1270                 1275             


Phe Cys  Asp Ala Trp Asn Thr  Phe Asp Ala Leu Ile  Val Val Gly 
    1280                 1285                 1290             


Ser Ile  Val Asp Ile Ala Ile  Thr Glu Val Asn Asn  Ala Glu Glu 
    1295                 1300                 1305             


Asn Ser  Arg Ile Ser Ile Thr  Phe Phe Arg Leu Phe  Arg Val Met 
    1310                 1315                 1320             


Arg Leu  Val Lys Leu Leu Ser  Arg Gly Glu Gly Ile  Arg Thr Leu 
    1325                 1330                 1335             


Leu Trp  Thr Phe Ile Lys Ser  Phe Gln Ala Leu Pro  Tyr Val Ala 
    1340                 1345                 1350             


Leu Leu  Ile Val Met Leu Phe  Phe Ile Tyr Ala Val  Ile Gly Met 
    1355                 1360                 1365             


Gln Val  Phe Gly Lys Ile Ala  Leu Asn Asp Thr Thr  Glu Ile Asn 
    1370                 1375                 1380             


Arg Asn  Asn Asn Phe Gln Thr  Phe Pro Gln Ala Val  Leu Leu Leu 
    1385                 1390                 1395             


Phe Arg  Cys Ala Thr Gly Glu  Ala Trp Gln Asp Ile  Met Leu Ala 
    1400                 1405                 1410             


Cys Met  Pro Gly Lys Lys Cys  Ala Pro Glu Ser Glu  Pro Ser Asn 
    1415                 1420                 1425             


Ser Thr  Glu Gly Glu Thr Pro  Cys Gly Ser Ser Phe  Ala Val Phe 
    1430                 1435                 1440             


Tyr Phe  Ile Ser Phe Tyr Met  Leu Cys Ala Phe Leu  Ile Ile Asn 
    1445                 1450                 1455             


Leu Phe  Val Ala Val Ile Met  Asp Asn Phe Asp Tyr  Leu Thr Arg 
    1460                 1465                 1470             


Asp Trp  Ser Ile Leu Gly Pro  His His Leu Asp Glu  Phe Lys Arg 
    1475                 1480                 1485             


Ile Trp  Ala Glu Tyr Asp Pro  Glu Ala Lys Gly Arg  Ile Lys His 
    1490                 1495                 1500             


Leu Asp  Val Val Thr Leu Leu  Arg Arg Ile Gln Pro  Pro Leu Gly 
    1505                 1510                 1515             


Phe Gly  Lys Leu Cys Pro His  Arg Val Ala Cys Lys  Arg Leu Val 
    1520                 1525                 1530             


Ser Met  Asn Met Pro Leu Asn  Ser Asp Gly Thr Val  Met Phe Asn 
    1535                 1540                 1545             


Ala Thr  Leu Phe Ala Leu Val  Arg Thr Ala Leu Arg  Ile Lys Thr 
    1550                 1555                 1560             


Glu Glu  Gly Pro Ser Pro Ser  Glu Ala His Gln Gly  Ala Glu Asp 
    1565                 1570                 1575             


Pro Phe  Arg Pro Ala Gly Asn  Leu Glu Gln Ala Asn  Glu Glu Leu 
    1580                 1585                 1590             


Arg Ala  Ile Ile Lys Lys Ile  Trp Lys Arg Thr Ser  Met Lys Leu 
    1595                 1600                 1605             


Leu Asp  Gln Val Val Pro Pro  Ala Gly Asp Asp Glu  Val Thr Val 
    1610                 1615                 1620             


Gly Lys  Phe Tyr Ala Thr Phe  Leu Ile Gln Glu Tyr  Phe Arg Lys 
    1625                 1630                 1635             


Phe Lys  Lys Arg Lys Glu Gln  Gly Leu Val Gly Lys  Pro Ser Gln 
    1640                 1645                 1650             


Arg Asn  Ala Leu Ser Leu Gln  Ala Gly Leu Arg Thr  Leu His Asp 
    1655                 1660                 1665             


Ile Gly  Pro Glu Ile Arg Arg  Ala Ile Ser Gly Asp  Leu Thr Ala 
    1670                 1675                 1680             


Glu Glu  Glu Leu Asp Lys Ala  Met Lys Glu Ala Val  Ser Ala Ala 
    1685                 1690                 1695             


Ser Glu  Asp Asp Ile Phe Arg  Arg Ala Gly Gly Leu  Phe Gly Asn 
    1700                 1705                 1710             


His Val  Ser Tyr Tyr Gln Ser  Asp Gly Arg Ser Ala  Phe Pro Gln 
    1715                 1720                 1725             


Thr Phe  Thr Thr Gln Arg Pro  Leu His Ile Asn Lys  Ala Gly Ser 
    1730                 1735                 1740             


Ser Gln  Gly Asp Thr Glu Ser  Pro Ser His Glu Lys  Leu Val Asp 
    1745                 1750                 1755             


Ser Thr  Phe Thr Pro Ser Ser  Tyr Ser Ser Thr Gly  Ser Asn Ala 
    1760                 1765                 1770             


Asn Ile  Asn Asn Ala Asn Asn  Thr Ala Leu Gly Arg  Leu Pro Arg 
    1775                 1780                 1785             


Pro Ala  Gly Tyr Pro Ser Thr  Val Ser Thr Val Glu  Gly His Gly 
    1790                 1795                 1800             


Pro Pro  Leu Ser Pro Ala Ile  Arg Val Gln Glu Val  Ala Trp Lys 
    1805                 1810                 1815             


Leu Ser  Ser Asn Arg Cys His  Ser Arg Glu Ser Gln  Ala Ala Met 
    1820                 1825                 1830             


Ala Gly  Gln Glu Glu Thr Ser  Gln Asp Glu Thr Tyr  Glu Val Lys 
    1835                 1840                 1845             


Met Asn  His Asp Thr Glu Ala  Cys Ser Glu Pro Ser  Leu Leu Ser 
    1850                 1855                 1860             


Thr Glu  Met Leu Ser Tyr Gln  Asp Asp Glu Asn Arg  Gln Leu Thr 
    1865                 1870                 1875             


Leu Pro  Glu Glu Asp Lys Arg  Asp Ile Arg Gln Ser  Pro Lys Arg 
    1880                 1885                 1890             


Gly Phe  Leu Arg Ser Ala Ser  Leu Gly Arg Arg Ala  Ser Phe His 
    1895                 1900                 1905             


Leu Glu  Cys Leu Lys Arg Gln  Lys Asp Arg Gly Gly  Asp Ile Ser 
    1910                 1915                 1920             


Gln Lys  Thr Val Leu Pro Leu  His Leu Val His His  Gln Ala Leu 
    1925                 1930                 1935             


Ala Val  Ala Gly Leu Ser Pro  Leu Leu Gln Arg Ser  His Ser Pro 
    1940                 1945                 1950             


Ala Ser  Phe Pro Arg Pro Phe  Ala Thr Pro Pro Ala  Thr Pro Gly 
    1955                 1960                 1965             


Ser Arg  Gly Trp Pro Pro Gln  Pro Val Pro Thr Leu  Arg Leu Glu 
    1970                 1975                 1980             


Gly Val  Glu Ser Ser Glu Lys  Leu Asn Ser Ser Phe  Pro Ser Ile 
    1985                 1990                 1995             


His Cys  Gly Ser Trp Ala Glu  Thr Thr Pro Gly Gly  Gly Gly Ser 
    2000                 2005                 2010             


Ser Ala  Ala Arg Arg Val Arg  Pro Val Ser Leu Met  Val Pro Ser 
    2015                 2020                 2025             


Gln Ala  Gly Ala Pro Gly Arg  Gln Phe His Gly Ser  Ala Ser Ser 
    2030                 2035                 2040             


Leu Val  Glu Ala Val Leu Ile  Ser Glu Gly Leu Gly  Gln Phe Ala 
    2045                 2050                 2055             


Gln Asp  Pro Lys Phe Ile Glu  Val Thr Thr Gln Glu  Leu Ala Asp 
    2060                 2065                 2070             


Ala Cys  Asp Met Thr Ile Glu  Glu Met Glu Ser Ala  Ala Asp Asn 
    2075                 2080                 2085             


Ile Leu  Ser Gly Gly Ala Pro  Gln Ser Pro Asn Gly  Ala Leu Leu 
    2090                 2095                 2100             


Pro Phe  Val Asn Cys Arg Asp  Ala Gly Gln Asp Arg  Ala Gly Gly 
    2105                 2110                 2115             


Glu Glu  Asp Ala Gly Cys Val  Arg Ala Arg Gly Arg  Pro Ser Glu 
    2120                 2125                 2130             


Glu Glu  Leu Gln Asp Ser Arg  Val Tyr Val Ser Ser  Leu 
    2135                 2140                 2145     


<210>  1395
<211>  2144
<212>  PRT
<213>  Homo sapiens

<400>  1395

Met Val Asn Glu Asn Thr Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser Thr Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Thr Thr 
                85                  90                  95      


Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Thr 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Thr Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Thr Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Thr Glu Val Gln Asp Thr Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Thr Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr Ile Leu Val Glu Thr 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Thr Arg Arg Ser Thr 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Thr Val Phe Gln Ile Leu Thr 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Thr Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Thr Thr Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Thr Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Thr Thr Ile Phe 
    930                 935                 940                 


Thr Ile Glu Ile Ala Leu Lys Met Thr Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Thr Ile Gly  Asn Ile Val Ile Val  Thr Thr Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Thr Cys Ser Asp  Ser Ser Lys Gln Thr  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Thr  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Thr  Val Ser Thr 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Thr Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Thr Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Thr Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Thr 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Thr Gly  Leu Phe Thr 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys His Tyr 
    1265                 1270                 1275             


Phe Cys  Asp Ala Trp Asn Thr  Phe Asp Ala Leu Ile  Val Val Gly 
    1280                 1285                 1290             


Ser Ile  Val Asp Ile Ala Ile  Thr Glu Asn Ala Glu  Glu Asn Ser 
    1295                 1300                 1305             


Arg Ile  Ser Ile Thr Phe Phe  Arg Leu Phe Arg Val  Met Arg Leu 
    1310                 1315                 1320             


Val Lys  Leu Leu Ser Arg Gly  Glu Gly Ile Arg Thr  Leu Leu Trp 
    1325                 1330                 1335             


Thr Phe  Ile Lys Ser Phe Gln  Ala Leu Pro Tyr Val  Ala Leu Leu 
    1340                 1345                 1350             


Ile Val  Met Leu Phe Phe Ile  Tyr Ala Val Ile Gly  Met Gln Val 
    1355                 1360                 1365             


Phe Gly  Lys Ile Ala Leu Asn  Asp Thr Thr Glu Ile  Asn Arg Asn 
    1370                 1375                 1380             


Asn Asn  Phe Gln Thr Phe Pro  Gln Ala Val Leu Leu  Leu Phe Arg 
    1385                 1390                 1395             


Cys Ala  Thr Gly Glu Ala Trp  Gln Asp Ile Met Leu  Ala Cys Met 
    1400                 1405                 1410             


Pro Gly  Lys Lys Cys Ala Pro  Glu Ser Glu Pro Ser  Asn Ser Thr 
    1415                 1420                 1425             


Glu Gly  Glu Thr Pro Cys Gly  Ser Ser Phe Ala Val  Phe Tyr Phe 
    1430                 1435                 1440             


Ile Ser  Phe Tyr Met Leu Cys  Ala Phe Leu Ile Ile  Asn Leu Phe 
    1445                 1450                 1455             


Val Ala  Val Ile Met Asp Asn  Phe Asp Tyr Leu Thr  Arg Asp Trp 
    1460                 1465                 1470             


Ser Ile  Leu Gly Pro His His  Leu Asp Glu Phe Lys  Arg Ile Trp 
    1475                 1480                 1485             


Ala Glu  Tyr Asp Pro Glu Ala  Lys Gly Arg Ile Lys  His Leu Asp 
    1490                 1495                 1500             


Val Val  Thr Leu Leu Arg Arg  Ile Gln Pro Pro Leu  Gly Phe Gly 
    1505                 1510                 1515             


Lys Leu  Cys Pro His Arg Val  Ala Cys Lys Arg Leu  Val Ser Met 
    1520                 1525                 1530             


Asn Met  Pro Leu Asn Ser Asp  Gly Thr Val Met Phe  Asn Ala Thr 
    1535                 1540                 1545             


Leu Phe  Ala Leu Val Arg Thr  Ala Leu Arg Ile Lys  Thr Glu Glu 
    1550                 1555                 1560             


Gly Pro  Ser Pro Ser Glu Ala  His Gln Gly Ala Glu  Asp Pro Phe 
    1565                 1570                 1575             


Arg Pro  Ala Gly Asn Leu Glu  Gln Ala Asn Glu Glu  Leu Arg Ala 
    1580                 1585                 1590             


Ile Ile  Lys Lys Ile Trp Lys  Arg Thr Ser Met Lys  Leu Leu Asp 
    1595                 1600                 1605             


Gln Val  Val Pro Pro Ala Gly  Asp Asp Glu Val Thr  Val Gly Lys 
    1610                 1615                 1620             


Phe Tyr  Ala Thr Phe Leu Ile  Gln Glu Tyr Phe Arg  Lys Phe Lys 
    1625                 1630                 1635             


Lys Arg  Lys Glu Gln Gly Leu  Val Gly Lys Pro Ser  Gln Arg Asn 
    1640                 1645                 1650             


Ala Leu  Ser Leu Gln Ala Gly  Leu Arg Thr Leu His  Asp Ile Gly 
    1655                 1660                 1665             


Pro Glu  Ile Arg Arg Ala Ile  Ser Gly Asp Leu Thr  Ala Glu Glu 
    1670                 1675                 1680             


Glu Leu  Asp Lys Ala Met Lys  Glu Ala Val Ser Ala  Ala Ser Glu 
    1685                 1690                 1695             


Asp Asp  Ile Phe Arg Arg Ala  Gly Gly Leu Phe Gly  Asn His Val 
    1700                 1705                 1710             


Ser Tyr  Tyr Gln Ser Asp Gly  Arg Ser Ala Phe Pro  Gln Thr Phe 
    1715                 1720                 1725             


Thr Thr  Gln Arg Pro Leu His  Ile Asn Lys Ala Gly  Ser Ser Gln 
    1730                 1735                 1740             


Gly Asp  Thr Glu Ser Pro Ser  His Glu Lys Leu Val  Asp Ser Thr 
    1745                 1750                 1755             


Phe Thr  Pro Ser Ser Tyr Ser  Ser Thr Gly Ser Asn  Ala Asn Ile 
    1760                 1765                 1770             


Asn Asn  Ala Asn Asn Thr Ala  Leu Gly Arg Leu Pro  Arg Pro Ala 
    1775                 1780                 1785             


Gly Tyr  Pro Ser Thr Val Ser  Thr Val Glu Gly His  Gly Pro Pro 
    1790                 1795                 1800             


Leu Ser  Pro Ala Ile Arg Val  Gln Glu Val Ala Trp  Lys Leu Ser 
    1805                 1810                 1815             


Ser Asn  Arg Cys His Ser Arg  Glu Ser Gln Ala Ala  Met Ala Gly 
    1820                 1825                 1830             


Gln Glu  Glu Thr Ser Gln Asp  Glu Thr Tyr Glu Val  Lys Met Asn 
    1835                 1840                 1845             


His Asp  Thr Glu Ala Cys Ser  Glu Pro Ser Leu Leu  Ser Thr Glu 
    1850                 1855                 1860             


Met Leu  Ser Tyr Gln Asp Asp  Glu Asn Arg Gln Leu  Thr Leu Pro 
    1865                 1870                 1875             


Glu Glu  Asp Lys Arg Asp Ile  Arg Gln Ser Pro Lys  Arg Gly Phe 
    1880                 1885                 1890             


Leu Arg  Ser Ala Ser Leu Gly  Arg Arg Ala Ser Phe  His Leu Glu 
    1895                 1900                 1905             


Cys Leu  Lys Arg Gln Lys Asp  Arg Gly Gly Asp Ile  Ser Gln Lys 
    1910                 1915                 1920             


Thr Val  Leu Pro Leu His Leu  Val His His Gln Ala  Leu Ala Val 
    1925                 1930                 1935             


Ala Gly  Leu Ser Pro Leu Leu  Gln Arg Ser His Ser  Pro Ala Ser 
    1940                 1945                 1950             


Phe Pro  Arg Pro Phe Ala Thr  Pro Pro Ala Thr Pro  Gly Ser Arg 
    1955                 1960                 1965             


Gly Trp  Pro Pro Gln Pro Val  Pro Thr Leu Arg Leu  Glu Gly Val 
    1970                 1975                 1980             


Glu Ser  Ser Glu Lys Leu Asn  Ser Ser Phe Pro Ser  Ile His Cys 
    1985                 1990                 1995             


Gly Ser  Trp Ala Glu Thr Thr  Pro Gly Gly Gly Gly  Ser Ser Ala 
    2000                 2005                 2010             


Ala Arg  Arg Val Arg Pro Val  Ser Leu Met Val Pro  Ser Gln Ala 
    2015                 2020                 2025             


Gly Ala  Pro Gly Arg Gln Phe  His Gly Ser Ala Ser  Ser Leu Val 
    2030                 2035                 2040             


Glu Ala  Val Leu Ile Ser Glu  Gly Leu Gly Gln Phe  Ala Gln Asp 
    2045                 2050                 2055             


Pro Lys  Phe Ile Glu Val Thr  Thr Gln Glu Leu Ala  Asp Ala Cys 
    2060                 2065                 2070             


Asp Met  Thr Ile Glu Glu Met  Glu Ser Ala Ala Asp  Asn Ile Leu 
    2075                 2080                 2085             


Ser Gly  Gly Ala Pro Gln Ser  Pro Asn Gly Ala Leu  Leu Pro Phe 
    2090                 2095                 2100             


Val Asn  Cys Arg Asp Ala Gly  Gln Asp Arg Ala Gly  Gly Glu Glu 
    2105                 2110                 2115             


Asp Ala  Gly Cys Val Arg Ala  Arg Gly Arg Pro Ser  Glu Glu Glu 
    2120                 2125                 2130             


Leu Gln  Asp Ser Arg Val Tyr  Val Ser Ser Leu 
    2135                 2140                 


<210>  1396
<211>  2138
<212>  PRT
<213>  Homo sapiens

<400>  1396

Met Val Asn Glu Asn Thr Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser Thr Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Thr Thr 
                85                  90                  95      


Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Thr 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Thr Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val 
        355                 360                 365             


Leu Tyr Trp Met Gln Asp Ala Met Gly Tyr Glu Leu Pro Trp Val Tyr 
    370                 375                 380                 


Phe Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Thr Glu Val Gln Asp Thr Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Thr Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr Ile Leu Val Glu Thr 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Thr Arg Arg Ser Thr 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Thr Val Phe Gln Ile Leu Thr 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Thr Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Thr Thr Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Thr Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Gly Asn Ala Asp Tyr Val Phe Thr Ser Ile Phe 
    930                 935                 940                 


Thr Leu Glu Ile Ile Leu Lys Met Thr Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Thr Ile Gly  Asn Ile Val Ile Val  Thr Thr Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Thr Cys Ser Asp  Ser Ser Lys Gln Thr  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Thr  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Thr  Val Ser Thr 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Thr Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Thr Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Thr Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Thr 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Thr Gly  Leu Phe Thr 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys His Tyr 
    1265                 1270                 1275             


Phe Cys  Asp Ala Trp Asn Thr  Phe Asp Ala Leu Ile  Val Val Gly 
    1280                 1285                 1290             


Ser Ile  Val Asp Ile Ala Ile  Thr Glu Val Asn Pro  Ala Glu His 
    1295                 1300                 1305             


Thr Gln  Cys Ser Pro Ser Met  Asn Ala Glu Glu Asn  Ser Arg Ile 
    1310                 1315                 1320             


Ser Ile  Thr Phe Phe Arg Leu  Phe Arg Val Met Arg  Leu Val Lys 
    1325                 1330                 1335             


Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Thr Leu Leu  Trp Thr Phe 
    1340                 1345                 1350             


Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Val 
    1355                 1360                 1365             


Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly Met Gln  Val Phe Gly 
    1370                 1375                 1380             


Lys Ile  Ala Leu Asn Asp Thr  Thr Glu Ile Asn Arg  Asn Asn Asn 
    1385                 1390                 1395             


Phe Gln  Thr Phe Pro Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala 
    1400                 1405                 1410             


Thr Gly  Glu Ala Trp Gln Asp  Ile Met Leu Ala Cys  Met Pro Gly 
    1415                 1420                 1425             


Lys Lys  Cys Ala Pro Glu Ser  Glu Pro Ser Asn Ser  Thr Glu Gly 
    1430                 1435                 1440             


Glu Thr  Pro Cys Gly Ser Ser  Phe Ala Val Phe Tyr  Phe Ile Ser 
    1445                 1450                 1455             


Phe Tyr  Met Leu Cys Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala 
    1460                 1465                 1470             


Val Ile  Met Asp Asn Phe Asp  Tyr Leu Thr Arg Asp  Trp Ser Ile 
    1475                 1480                 1485             


Leu Gly  Pro His His Leu Asp  Glu Phe Lys Arg Ile  Trp Ala Glu 
    1490                 1495                 1500             


Tyr Asp  Pro Glu Ala Lys Gly  Arg Ile Lys His Leu  Asp Val Val 
    1505                 1510                 1515             


Thr Leu  Leu Arg Arg Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu 
    1520                 1525                 1530             


Cys Pro  His Arg Val Ala Cys  Lys Arg Leu Val Ser  Met Asn Met 
    1535                 1540                 1545             


Pro Leu  Asn Ser Asp Gly Thr  Val Met Phe Asn Ala  Thr Leu Phe 
    1550                 1555                 1560             


Ala Leu  Val Arg Thr Ala Leu  Arg Ile Lys Thr Glu  Gly Asn Leu 
    1565                 1570                 1575             


Glu Gln  Ala Asn Glu Glu Leu  Arg Ala Ile Ile Lys  Lys Ile Trp 
    1580                 1585                 1590             


Lys Arg  Thr Ser Met Lys Leu  Leu Asp Gln Val Val  Pro Pro Ala 
    1595                 1600                 1605             


Gly Asp  Asp Glu Val Thr Val  Gly Lys Phe Tyr Ala  Thr Phe Leu 
    1610                 1615                 1620             


Ile Gln  Glu Tyr Phe Arg Lys  Phe Lys Lys Arg Lys  Glu Gln Gly 
    1625                 1630                 1635             


Leu Val  Gly Lys Pro Ser Gln  Arg Asn Ala Leu Ser  Leu Gln Ala 
    1640                 1645                 1650             


Gly Leu  Arg Thr Leu His Asp  Ile Gly Pro Glu Ile  Arg Arg Ala 
    1655                 1660                 1665             


Ile Ser  Gly Asp Leu Thr Ala  Glu Glu Glu Leu Asp  Lys Ala Met 
    1670                 1675                 1680             


Lys Glu  Ala Val Ser Ala Ala  Ser Glu Asp Asp Ile  Phe Arg Arg 
    1685                 1690                 1695             


Ala Gly  Gly Leu Phe Gly Asn  His Val Ser Tyr Tyr  Gln Ser Asp 
    1700                 1705                 1710             


Gly Arg  Ser Ala Phe Pro Gln  Thr Phe Thr Thr Gln  Arg Pro Leu 
    1715                 1720                 1725             


His Ile  Asn Lys Ala Gly Ser  Ser Gln Gly Asp Thr  Glu Ser Pro 
    1730                 1735                 1740             


Ser His  Glu Lys Leu Val Asp  Ser Thr Phe Thr Pro  Ser Ser Tyr 
    1745                 1750                 1755             


Ser Ser  Thr Gly Ser Asn Ala  Asn Ile Asn Asn Ala  Asn Asn Thr 
    1760                 1765                 1770             


Ala Leu  Gly Arg Leu Pro Arg  Pro Ala Gly Tyr Pro  Ser Thr Val 
    1775                 1780                 1785             


Ser Thr  Val Glu Gly His Gly  Pro Pro Leu Ser Pro  Ala Ile Arg 
    1790                 1795                 1800             


Val Gln  Glu Val Ala Trp Lys  Leu Ser Ser Asn Arg  Cys His Ser 
    1805                 1810                 1815             


Arg Glu  Ser Gln Ala Ala Met  Ala Gly Gln Glu Glu  Thr Ser Gln 
    1820                 1825                 1830             


Asp Glu  Thr Tyr Glu Val Lys  Met Asn His Asp Thr  Glu Ala Cys 
    1835                 1840                 1845             


Ser Glu  Pro Ser Leu Leu Ser  Thr Glu Met Leu Ser  Tyr Gln Asp 
    1850                 1855                 1860             


Asp Glu  Asn Arg Gln Leu Thr  Leu Pro Glu Glu Asp  Lys Arg Asp 
    1865                 1870                 1875             


Ile Arg  Gln Ser Pro Lys Arg  Gly Phe Leu Arg Ser  Ala Ser Leu 
    1880                 1885                 1890             


Gly Arg  Arg Ala Ser Phe His  Leu Glu Cys Leu Lys  Arg Gln Lys 
    1895                 1900                 1905             


Asp Arg  Gly Gly Asp Ile Ser  Gln Lys Thr Val Leu  Pro Leu His 
    1910                 1915                 1920             


Leu Val  His His Gln Ala Leu  Ala Val Ala Gly Leu  Ser Pro Leu 
    1925                 1930                 1935             


Leu Gln  Arg Ser His Ser Pro  Ala Ser Phe Pro Arg  Pro Phe Ala 
    1940                 1945                 1950             


Thr Pro  Pro Ala Thr Pro Gly  Ser Arg Gly Trp Pro  Pro Gln Pro 
    1955                 1960                 1965             


Val Pro  Thr Leu Arg Leu Glu  Gly Val Glu Ser Ser  Glu Lys Leu 
    1970                 1975                 1980             


Asn Ser  Ser Phe Pro Ser Ile  His Cys Gly Ser Trp  Ala Glu Thr 
    1985                 1990                 1995             


Thr Pro  Gly Gly Gly Gly Ser  Ser Ala Ala Arg Arg  Val Arg Pro 
    2000                 2005                 2010             


Val Ser  Leu Met Val Pro Ser  Gln Ala Gly Ala Pro  Gly Arg Gln 
    2015                 2020                 2025             


Phe His  Gly Ser Ala Ser Ser  Leu Val Glu Ala Val  Leu Ile Ser 
    2030                 2035                 2040             


Glu Gly  Leu Gly Gln Phe Ala  Gln Asp Pro Lys Phe  Ile Glu Val 
    2045                 2050                 2055             


Thr Thr  Gln Glu Leu Ala Asp  Ala Cys Asp Met Thr  Ile Glu Glu 
    2060                 2065                 2070             


Met Glu  Ser Ala Ala Asp Asn  Ile Leu Ser Gly Gly  Ala Pro Gln 
    2075                 2080                 2085             


Ser Pro  Asn Gly Ala Leu Leu  Pro Phe Val Asn Cys  Arg Asp Ala 
    2090                 2095                 2100             


Gly Gln  Asp Arg Ala Gly Gly  Glu Glu Asp Ala Gly  Cys Val Arg 
    2105                 2110                 2115             


Ala Arg  Gly Arg Pro Ser Glu  Glu Glu Leu Gln Asp  Ser Arg Val 
    2120                 2125                 2130             


Tyr Val  Ser Ser Leu 
    2135             


<210>  1397
<211>  2138
<212>  PRT
<213>  Homo sapiens

<400>  1397

Met Val Asn Glu Asn Thr Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser Thr Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Thr Thr 
                85                  90                  95      


Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Thr 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Thr Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Thr Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Thr Glu Val Gln Asp Thr Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Thr Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr Ile Leu Val Glu Thr 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Thr Arg Arg Ser Thr 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Thr Val Phe Gln Ile Leu Thr 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Thr Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Thr Thr Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Thr Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Gly Asn Ala Asp Tyr Val Phe Thr Ser Ile Phe 
    930                 935                 940                 


Thr Leu Glu Ile Ile Leu Lys Met Thr Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Thr Ile Gly  Asn Ile Val Ile Val  Thr Thr Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Thr Cys Ser Asp  Ser Ser Lys Gln Thr  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Thr  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Thr  Val Ser Thr 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Thr Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Thr Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Thr Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Thr 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Thr Gly  Leu Phe Thr 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys Gly Tyr 
    1265                 1270                 1275             


Phe Ser  Asp Pro Trp Asn Val  Phe Asp Phe Leu Ile  Val Ile Gly 
    1280                 1285                 1290             


Ser Ile  Ile Asp Val Ile Leu  Ser Glu Thr Asn Pro  Ala Glu His 
    1295                 1300                 1305             


Thr Gln  Cys Ser Pro Ser Met  Asn Ala Glu Glu Asn  Ser Arg Ile 
    1310                 1315                 1320             


Ser Ile  Thr Phe Phe Arg Leu  Phe Arg Val Met Arg  Leu Val Lys 
    1325                 1330                 1335             


Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Thr Leu Leu  Trp Thr Phe 
    1340                 1345                 1350             


Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Val 
    1355                 1360                 1365             


Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly Met Gln  Val Phe Gly 
    1370                 1375                 1380             


Lys Ile  Ala Leu Asn Asp Thr  Thr Glu Ile Asn Arg  Asn Asn Asn 
    1385                 1390                 1395             


Phe Gln  Thr Phe Pro Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala 
    1400                 1405                 1410             


Thr Gly  Glu Ala Trp Gln Asp  Ile Met Leu Ala Cys  Met Pro Gly 
    1415                 1420                 1425             


Lys Lys  Cys Ala Pro Glu Ser  Glu Pro Ser Asn Ser  Thr Glu Gly 
    1430                 1435                 1440             


Glu Thr  Pro Cys Gly Ser Ser  Phe Ala Val Phe Tyr  Phe Ile Ser 
    1445                 1450                 1455             


Phe Tyr  Met Leu Cys Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala 
    1460                 1465                 1470             


Val Ile  Met Asp Asn Phe Asp  Tyr Leu Thr Arg Asp  Trp Ser Ile 
    1475                 1480                 1485             


Leu Gly  Pro His His Leu Asp  Glu Phe Lys Arg Ile  Trp Ala Glu 
    1490                 1495                 1500             


Tyr Asp  Pro Glu Ala Lys Gly  Arg Ile Lys His Leu  Asp Val Val 
    1505                 1510                 1515             


Thr Leu  Leu Arg Arg Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu 
    1520                 1525                 1530             


Cys Pro  His Arg Val Ala Cys  Lys Arg Leu Val Ser  Met Asn Met 
    1535                 1540                 1545             


Pro Leu  Asn Ser Asp Gly Thr  Val Met Phe Asn Ala  Thr Leu Phe 
    1550                 1555                 1560             


Ala Leu  Val Arg Thr Ala Leu  Arg Ile Lys Thr Glu  Gly Asn Leu 
    1565                 1570                 1575             


Glu Gln  Ala Asn Glu Glu Leu  Arg Ala Ile Ile Lys  Lys Ile Trp 
    1580                 1585                 1590             


Lys Arg  Thr Ser Met Lys Leu  Leu Asp Gln Val Val  Pro Pro Ala 
    1595                 1600                 1605             


Gly Asp  Asp Glu Val Thr Val  Gly Lys Phe Tyr Ala  Thr Phe Leu 
    1610                 1615                 1620             


Ile Gln  Glu Tyr Phe Arg Lys  Phe Lys Lys Arg Lys  Glu Gln Gly 
    1625                 1630                 1635             


Leu Val  Gly Lys Pro Ser Gln  Arg Asn Ala Leu Ser  Leu Gln Ala 
    1640                 1645                 1650             


Gly Leu  Arg Thr Leu His Asp  Ile Gly Pro Glu Ile  Arg Arg Ala 
    1655                 1660                 1665             


Ile Ser  Gly Asp Leu Thr Ala  Glu Glu Glu Leu Asp  Lys Ala Met 
    1670                 1675                 1680             


Lys Glu  Ala Val Ser Ala Ala  Ser Glu Asp Asp Ile  Phe Arg Arg 
    1685                 1690                 1695             


Ala Gly  Gly Leu Phe Gly Asn  His Val Ser Tyr Tyr  Gln Ser Asp 
    1700                 1705                 1710             


Gly Arg  Ser Ala Phe Pro Gln  Thr Phe Thr Thr Gln  Arg Pro Leu 
    1715                 1720                 1725             


His Ile  Asn Lys Ala Gly Ser  Ser Gln Gly Asp Thr  Glu Ser Pro 
    1730                 1735                 1740             


Ser His  Glu Lys Leu Val Asp  Ser Thr Phe Thr Pro  Ser Ser Tyr 
    1745                 1750                 1755             


Ser Ser  Thr Gly Ser Asn Ala  Asn Ile Asn Asn Ala  Asn Asn Thr 
    1760                 1765                 1770             


Ala Leu  Gly Arg Leu Pro Arg  Pro Ala Gly Tyr Pro  Ser Thr Val 
    1775                 1780                 1785             


Ser Thr  Val Glu Gly His Gly  Pro Pro Leu Ser Pro  Ala Ile Arg 
    1790                 1795                 1800             


Val Gln  Glu Val Ala Trp Lys  Leu Ser Ser Asn Arg  Cys His Ser 
    1805                 1810                 1815             


Arg Glu  Ser Gln Ala Ala Met  Ala Gly Gln Glu Glu  Thr Ser Gln 
    1820                 1825                 1830             


Asp Glu  Thr Tyr Glu Val Lys  Met Asn His Asp Thr  Glu Ala Cys 
    1835                 1840                 1845             


Ser Glu  Pro Ser Leu Leu Ser  Thr Glu Met Leu Ser  Tyr Gln Asp 
    1850                 1855                 1860             


Asp Glu  Asn Arg Gln Leu Thr  Leu Pro Glu Glu Asp  Lys Arg Asp 
    1865                 1870                 1875             


Ile Arg  Gln Ser Pro Lys Arg  Gly Phe Leu Arg Ser  Ala Ser Leu 
    1880                 1885                 1890             


Gly Arg  Arg Ala Ser Phe His  Leu Glu Cys Leu Lys  Arg Gln Lys 
    1895                 1900                 1905             


Asp Arg  Gly Gly Asp Ile Ser  Gln Lys Thr Val Leu  Pro Leu His 
    1910                 1915                 1920             


Leu Val  His His Gln Ala Leu  Ala Val Ala Gly Leu  Ser Pro Leu 
    1925                 1930                 1935             


Leu Gln  Arg Ser His Ser Pro  Ala Ser Phe Pro Arg  Pro Phe Ala 
    1940                 1945                 1950             


Thr Pro  Pro Ala Thr Pro Gly  Ser Arg Gly Trp Pro  Pro Gln Pro 
    1955                 1960                 1965             


Val Pro  Thr Leu Arg Leu Glu  Gly Val Glu Ser Ser  Glu Lys Leu 
    1970                 1975                 1980             


Asn Ser  Ser Phe Pro Ser Ile  His Cys Gly Ser Trp  Ala Glu Thr 
    1985                 1990                 1995             


Thr Pro  Gly Gly Gly Gly Ser  Ser Ala Ala Arg Arg  Val Arg Pro 
    2000                 2005                 2010             


Val Ser  Leu Met Val Pro Ser  Gln Ala Gly Ala Pro  Gly Arg Gln 
    2015                 2020                 2025             


Phe His  Gly Ser Ala Ser Ser  Leu Val Glu Ala Val  Leu Ile Ser 
    2030                 2035                 2040             


Glu Gly  Leu Gly Gln Phe Ala  Gln Asp Pro Lys Phe  Ile Glu Val 
    2045                 2050                 2055             


Thr Thr  Gln Glu Leu Ala Asp  Ala Cys Asp Met Thr  Ile Glu Glu 
    2060                 2065                 2070             


Met Glu  Ser Ala Ala Asp Asn  Ile Leu Ser Gly Gly  Ala Pro Gln 
    2075                 2080                 2085             


Ser Pro  Asn Gly Ala Leu Leu  Pro Phe Val Asn Cys  Arg Asp Ala 
    2090                 2095                 2100             


Gly Gln  Asp Arg Ala Gly Gly  Glu Glu Asp Ala Gly  Cys Val Arg 
    2105                 2110                 2115             


Ala Arg  Gly Arg Pro Ser Glu  Glu Glu Leu Gln Asp  Ser Arg Val 
    2120                 2125                 2130             


Tyr Val  Ser Ser Leu 
    2135             


<210>  1398
<211>  2138
<212>  PRT
<213>  Homo sapiens

<400>  1398

Met Val Asn Glu Asn Thr Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser Thr Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Thr Thr 
                85                  90                  95      


Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Thr 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Thr Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Thr Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Thr Glu Val Gln Asp Thr Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Thr Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr Ile Leu Val Glu Thr 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Thr Arg Arg Ser Thr 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Thr Val Phe Gln Ile Leu Thr 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Thr Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Thr Thr Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Thr Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Thr Thr Ile Phe 
    930                 935                 940                 


Thr Ile Glu Ile Ala Leu Lys Met Thr Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Thr Ile Gly  Asn Ile Val Ile Val  Thr Thr Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Thr Cys Ser Asp  Ser Ser Lys Gln Thr  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Thr  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Thr  Val Ser Thr 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Thr Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Thr Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Thr Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Thr 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Thr Gly  Leu Phe Thr 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys Gly Tyr 
    1265                 1270                 1275             


Phe Ser  Asp Pro Trp Asn Val  Phe Asp Phe Leu Ile  Val Ile Gly 
    1280                 1285                 1290             


Ser Ile  Ile Asp Val Ile Leu  Ser Glu Thr Asn Pro  Ala Glu His 
    1295                 1300                 1305             


Thr Gln  Cys Ser Pro Ser Met  Asn Ala Glu Glu Asn  Ser Arg Ile 
    1310                 1315                 1320             


Ser Ile  Thr Phe Phe Arg Leu  Phe Arg Val Met Arg  Leu Val Lys 
    1325                 1330                 1335             


Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Thr Leu Leu  Trp Thr Phe 
    1340                 1345                 1350             


Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Val 
    1355                 1360                 1365             


Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly Met Gln  Val Phe Gly 
    1370                 1375                 1380             


Lys Ile  Ala Leu Asn Asp Thr  Thr Glu Ile Asn Arg  Asn Asn Asn 
    1385                 1390                 1395             


Phe Gln  Thr Phe Pro Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala 
    1400                 1405                 1410             


Thr Gly  Glu Ala Trp Gln Asp  Ile Met Leu Ala Cys  Met Pro Gly 
    1415                 1420                 1425             


Lys Lys  Cys Ala Pro Glu Ser  Glu Pro Ser Asn Ser  Thr Glu Gly 
    1430                 1435                 1440             


Glu Thr  Pro Cys Gly Ser Ser  Phe Ala Val Phe Tyr  Phe Ile Ser 
    1445                 1450                 1455             


Phe Tyr  Met Leu Cys Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala 
    1460                 1465                 1470             


Val Ile  Met Asp Asn Phe Asp  Tyr Leu Thr Arg Asp  Trp Ser Ile 
    1475                 1480                 1485             


Leu Gly  Pro His His Leu Asp  Glu Phe Lys Arg Ile  Trp Ala Glu 
    1490                 1495                 1500             


Tyr Asp  Pro Glu Ala Lys Gly  Arg Ile Lys His Leu  Asp Val Val 
    1505                 1510                 1515             


Thr Leu  Leu Arg Arg Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu 
    1520                 1525                 1530             


Cys Pro  His Arg Val Ala Cys  Lys Arg Leu Val Ser  Met Asn Met 
    1535                 1540                 1545             


Pro Leu  Asn Ser Asp Gly Thr  Val Met Phe Asn Ala  Thr Leu Phe 
    1550                 1555                 1560             


Ala Leu  Val Arg Thr Ala Leu  Arg Ile Lys Thr Glu  Gly Asn Leu 
    1565                 1570                 1575             


Glu Gln  Ala Asn Glu Glu Leu  Arg Ala Ile Ile Lys  Lys Ile Trp 
    1580                 1585                 1590             


Lys Arg  Thr Ser Met Lys Leu  Leu Asp Gln Val Val  Pro Pro Ala 
    1595                 1600                 1605             


Gly Asp  Asp Glu Val Thr Val  Gly Lys Phe Tyr Ala  Thr Phe Leu 
    1610                 1615                 1620             


Ile Gln  Glu Tyr Phe Arg Lys  Phe Lys Lys Arg Lys  Glu Gln Gly 
    1625                 1630                 1635             


Leu Val  Gly Lys Pro Ser Gln  Arg Asn Ala Leu Ser  Leu Gln Ala 
    1640                 1645                 1650             


Gly Leu  Arg Thr Leu His Asp  Ile Gly Pro Glu Ile  Arg Arg Ala 
    1655                 1660                 1665             


Ile Ser  Gly Asp Leu Thr Ala  Glu Glu Glu Leu Asp  Lys Ala Met 
    1670                 1675                 1680             


Lys Glu  Ala Val Ser Ala Ala  Ser Glu Asp Asp Ile  Phe Arg Arg 
    1685                 1690                 1695             


Ala Gly  Gly Leu Phe Gly Asn  His Val Ser Tyr Tyr  Gln Ser Asp 
    1700                 1705                 1710             


Gly Arg  Ser Ala Phe Pro Gln  Thr Phe Thr Thr Gln  Arg Pro Leu 
    1715                 1720                 1725             


His Ile  Asn Lys Ala Gly Ser  Ser Gln Gly Asp Thr  Glu Ser Pro 
    1730                 1735                 1740             


Ser His  Glu Lys Leu Val Asp  Ser Thr Phe Thr Pro  Ser Ser Tyr 
    1745                 1750                 1755             


Ser Ser  Thr Gly Ser Asn Ala  Asn Ile Asn Asn Ala  Asn Asn Thr 
    1760                 1765                 1770             


Ala Leu  Gly Arg Leu Pro Arg  Pro Ala Gly Tyr Pro  Ser Thr Val 
    1775                 1780                 1785             


Ser Thr  Val Glu Gly His Gly  Pro Pro Leu Ser Pro  Ala Ile Arg 
    1790                 1795                 1800             


Val Gln  Glu Val Ala Trp Lys  Leu Ser Ser Asn Arg  Cys His Ser 
    1805                 1810                 1815             


Arg Glu  Ser Gln Ala Ala Met  Ala Gly Gln Glu Glu  Thr Ser Gln 
    1820                 1825                 1830             


Asp Glu  Thr Tyr Glu Val Lys  Met Asn His Asp Thr  Glu Ala Cys 
    1835                 1840                 1845             


Ser Glu  Pro Ser Leu Leu Ser  Thr Glu Met Leu Ser  Tyr Gln Asp 
    1850                 1855                 1860             


Asp Glu  Asn Arg Gln Leu Thr  Leu Pro Glu Glu Asp  Lys Arg Asp 
    1865                 1870                 1875             


Ile Arg  Gln Ser Pro Lys Arg  Gly Phe Leu Arg Ser  Ala Ser Leu 
    1880                 1885                 1890             


Gly Arg  Arg Ala Ser Phe His  Leu Glu Cys Leu Lys  Arg Gln Lys 
    1895                 1900                 1905             


Asp Arg  Gly Gly Asp Ile Ser  Gln Lys Thr Val Leu  Pro Leu His 
    1910                 1915                 1920             


Leu Val  His His Gln Ala Leu  Ala Val Ala Gly Leu  Ser Pro Leu 
    1925                 1930                 1935             


Leu Gln  Arg Ser His Ser Pro  Ala Ser Phe Pro Arg  Pro Phe Ala 
    1940                 1945                 1950             


Thr Pro  Pro Ala Thr Pro Gly  Ser Arg Gly Trp Pro  Pro Gln Pro 
    1955                 1960                 1965             


Val Pro  Thr Leu Arg Leu Glu  Gly Val Glu Ser Ser  Glu Lys Leu 
    1970                 1975                 1980             


Asn Ser  Ser Phe Pro Ser Ile  His Cys Gly Ser Trp  Ala Glu Thr 
    1985                 1990                 1995             


Thr Pro  Gly Gly Gly Gly Ser  Ser Ala Ala Arg Arg  Val Arg Pro 
    2000                 2005                 2010             


Val Ser  Leu Met Val Pro Ser  Gln Ala Gly Ala Pro  Gly Arg Gln 
    2015                 2020                 2025             


Phe His  Gly Ser Ala Ser Ser  Leu Val Glu Ala Val  Leu Ile Ser 
    2030                 2035                 2040             


Glu Gly  Leu Gly Gln Phe Ala  Gln Asp Pro Lys Phe  Ile Glu Val 
    2045                 2050                 2055             


Thr Thr  Gln Glu Leu Ala Asp  Ala Cys Asp Met Thr  Ile Glu Glu 
    2060                 2065                 2070             


Met Glu  Ser Ala Ala Asp Asn  Ile Leu Ser Gly Gly  Ala Pro Gln 
    2075                 2080                 2085             


Ser Pro  Asn Gly Ala Leu Leu  Pro Phe Val Asn Cys  Arg Asp Ala 
    2090                 2095                 2100             


Gly Gln  Asp Arg Ala Gly Gly  Glu Glu Asp Ala Gly  Cys Val Arg 
    2105                 2110                 2115             


Ala Arg  Gly Arg Pro Ser Glu  Glu Glu Leu Gln Asp  Ser Arg Val 
    2120                 2125                 2130             


Tyr Val  Ser Ser Leu 
    2135             


<210>  1399
<211>  2138
<212>  PRT
<213>  Homo sapiens

<400>  1399

Met Val Asn Glu Asn Thr Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser Thr Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Thr Thr 
                85                  90                  95      


Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Thr 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Thr Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Thr Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Thr Glu Val Gln Asp Thr Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Thr Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr Ile Leu Val Glu Thr 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Thr Arg Arg Ser Thr 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Thr Val Phe Gln Ile Leu Thr 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Thr Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Thr Thr Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Thr Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Gly Asn Ala Asp Tyr Val Phe Thr Ser Ile Phe 
    930                 935                 940                 


Thr Leu Glu Ile Ile Leu Lys Met Thr Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Thr Ile Gly  Asn Ile Val Ile Val  Thr Thr Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Thr Cys Ser Asp  Ser Ser Lys Gln Thr  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Thr  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Thr  Val Ser Thr 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Thr Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Thr Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Thr Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Thr 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Thr Gly  Leu Phe Thr 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys His Tyr 
    1265                 1270                 1275             


Phe Cys  Asp Ala Trp Asn Thr  Phe Asp Ala Leu Ile  Val Val Gly 
    1280                 1285                 1290             


Ser Ile  Val Asp Ile Ala Ile  Thr Glu Val Asn Pro  Ala Glu His 
    1295                 1300                 1305             


Thr Gln  Cys Ser Pro Ser Met  Asn Ala Glu Glu Asn  Ser Arg Ile 
    1310                 1315                 1320             


Ser Ile  Thr Phe Phe Arg Leu  Phe Arg Val Met Arg  Leu Val Lys 
    1325                 1330                 1335             


Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Thr Leu Leu  Trp Thr Phe 
    1340                 1345                 1350             


Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Val 
    1355                 1360                 1365             


Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly Met Gln  Val Phe Gly 
    1370                 1375                 1380             


Lys Ile  Ala Leu Asn Asp Thr  Thr Glu Ile Asn Arg  Asn Asn Asn 
    1385                 1390                 1395             


Phe Gln  Thr Phe Pro Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala 
    1400                 1405                 1410             


Thr Gly  Glu Ala Trp Gln Asp  Ile Met Leu Ala Cys  Met Pro Gly 
    1415                 1420                 1425             


Lys Lys  Cys Ala Pro Glu Ser  Glu Pro Ser Asn Ser  Thr Glu Gly 
    1430                 1435                 1440             


Glu Thr  Pro Cys Gly Ser Ser  Phe Ala Val Phe Tyr  Phe Ile Ser 
    1445                 1450                 1455             


Phe Tyr  Met Leu Cys Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala 
    1460                 1465                 1470             


Val Ile  Met Asp Asn Phe Asp  Tyr Leu Thr Arg Asp  Trp Ser Ile 
    1475                 1480                 1485             


Leu Gly  Pro His His Leu Asp  Glu Phe Lys Arg Ile  Trp Ala Glu 
    1490                 1495                 1500             


Tyr Asp  Pro Glu Ala Lys Gly  Arg Ile Lys His Leu  Asp Val Val 
    1505                 1510                 1515             


Thr Leu  Leu Arg Arg Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu 
    1520                 1525                 1530             


Cys Pro  His Arg Val Ala Cys  Lys Arg Leu Val Ser  Met Asn Met 
    1535                 1540                 1545             


Pro Leu  Asn Ser Asp Gly Thr  Val Met Phe Asn Ala  Thr Leu Phe 
    1550                 1555                 1560             


Ala Leu  Val Arg Thr Ala Leu  Arg Ile Lys Thr Glu  Gly Asn Leu 
    1565                 1570                 1575             


Glu Gln  Ala Asn Glu Glu Leu  Arg Ala Ile Ile Lys  Lys Ile Trp 
    1580                 1585                 1590             


Lys Arg  Thr Ser Met Lys Leu  Leu Asp Gln Val Val  Pro Pro Ala 
    1595                 1600                 1605             


Gly Asp  Asp Glu Val Thr Val  Gly Lys Phe Tyr Ala  Thr Phe Leu 
    1610                 1615                 1620             


Ile Gln  Glu Tyr Phe Arg Lys  Phe Lys Lys Arg Lys  Glu Gln Gly 
    1625                 1630                 1635             


Leu Val  Gly Lys Pro Ser Gln  Arg Asn Ala Leu Ser  Leu Gln Ala 
    1640                 1645                 1650             


Gly Leu  Arg Thr Leu His Asp  Ile Gly Pro Glu Ile  Arg Arg Ala 
    1655                 1660                 1665             


Ile Ser  Gly Asp Leu Thr Ala  Glu Glu Glu Leu Asp  Lys Ala Met 
    1670                 1675                 1680             


Lys Glu  Ala Val Ser Ala Ala  Ser Glu Asp Asp Ile  Phe Arg Arg 
    1685                 1690                 1695             


Ala Gly  Gly Leu Phe Gly Asn  His Val Ser Tyr Tyr  Gln Ser Asp 
    1700                 1705                 1710             


Gly Arg  Ser Ala Phe Pro Gln  Thr Phe Thr Thr Gln  Arg Pro Leu 
    1715                 1720                 1725             


His Ile  Asn Lys Ala Gly Ser  Ser Gln Gly Asp Thr  Glu Ser Pro 
    1730                 1735                 1740             


Ser His  Glu Lys Leu Val Asp  Ser Thr Phe Thr Pro  Ser Ser Tyr 
    1745                 1750                 1755             


Ser Ser  Thr Gly Ser Asn Ala  Asn Ile Asn Asn Ala  Asn Asn Thr 
    1760                 1765                 1770             


Ala Leu  Gly Arg Leu Pro Arg  Pro Ala Gly Tyr Pro  Ser Thr Val 
    1775                 1780                 1785             


Ser Thr  Val Glu Gly His Gly  Pro Pro Leu Ser Pro  Ala Ile Arg 
    1790                 1795                 1800             


Val Gln  Glu Val Ala Trp Lys  Leu Ser Ser Asn Arg  Cys His Ser 
    1805                 1810                 1815             


Arg Glu  Ser Gln Ala Ala Met  Ala Gly Gln Glu Glu  Thr Ser Gln 
    1820                 1825                 1830             


Asp Glu  Thr Tyr Glu Val Lys  Met Asn His Asp Thr  Glu Ala Cys 
    1835                 1840                 1845             


Ser Glu  Pro Ser Leu Leu Ser  Thr Glu Met Leu Ser  Tyr Gln Asp 
    1850                 1855                 1860             


Asp Glu  Asn Arg Gln Leu Thr  Leu Pro Glu Glu Asp  Lys Arg Asp 
    1865                 1870                 1875             


Ile Arg  Gln Ser Pro Lys Arg  Gly Phe Leu Arg Ser  Ala Ser Leu 
    1880                 1885                 1890             


Gly Arg  Arg Ala Ser Phe His  Leu Glu Cys Leu Lys  Arg Gln Lys 
    1895                 1900                 1905             


Asp Arg  Gly Gly Asp Ile Ser  Gln Lys Thr Val Leu  Pro Leu His 
    1910                 1915                 1920             


Leu Val  His His Gln Ala Leu  Ala Val Ala Gly Leu  Ser Pro Leu 
    1925                 1930                 1935             


Leu Gln  Arg Ser His Ser Pro  Ala Ser Phe Pro Arg  Pro Phe Ala 
    1940                 1945                 1950             


Thr Pro  Pro Ala Thr Pro Gly  Ser Arg Gly Trp Pro  Pro Gln Pro 
    1955                 1960                 1965             


Val Pro  Thr Leu Arg Leu Glu  Gly Val Glu Ser Ser  Glu Lys Leu 
    1970                 1975                 1980             


Asn Ser  Ser Phe Pro Ser Ile  His Cys Gly Ser Trp  Ala Glu Thr 
    1985                 1990                 1995             


Thr Pro  Gly Gly Gly Gly Ser  Ser Ala Ala Arg Arg  Val Arg Pro 
    2000                 2005                 2010             


Val Ser  Leu Met Val Pro Ser  Gln Ala Gly Ala Pro  Gly Arg Gln 
    2015                 2020                 2025             


Phe His  Gly Ser Ala Ser Ser  Leu Val Glu Ala Val  Leu Ile Ser 
    2030                 2035                 2040             


Glu Gly  Leu Gly Gln Phe Ala  Gln Asp Pro Lys Phe  Ile Glu Val 
    2045                 2050                 2055             


Thr Thr  Gln Glu Leu Ala Asp  Ala Cys Asp Met Thr  Ile Glu Glu 
    2060                 2065                 2070             


Met Glu  Ser Ala Ala Asp Asn  Ile Leu Ser Gly Gly  Ala Pro Gln 
    2075                 2080                 2085             


Ser Pro  Asn Gly Ala Leu Leu  Pro Phe Val Asn Cys  Arg Asp Ala 
    2090                 2095                 2100             


Gly Gln  Asp Arg Ala Gly Gly  Glu Glu Asp Ala Gly  Cys Val Arg 
    2105                 2110                 2115             


Ala Arg  Gly Arg Pro Ser Glu  Glu Glu Leu Gln Asp  Ser Arg Val 
    2120                 2125                 2130             


Tyr Val  Ser Ser Leu 
    2135             


<210>  1400
<211>  2135
<212>  PRT
<213>  Homo sapiens

<400>  1400

Met Val Asn Glu Asn Thr Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser Thr Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Thr Thr 
                85                  90                  95      


Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Thr Gly His Gly 
305                 310                 315                 320 


Arg Gln Cys Gln Asn Gly Thr Val Cys Lys Pro Gly Trp Asp Gly Pro 
                325                 330                 335     


Lys His Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe Ala Met Leu Thr 
            340                 345                 350         


Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val Leu Tyr Trp 
        355                 360                 365             


Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr Phe Val Thr 
    370                 375                 380                 


Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val Leu Gly Val 
385                 390                 395                 400 


Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys Ala Arg Gly 
                405                 410                 415     


Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu Asp Leu Lys 
            420                 425                 430         


Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile Asp Pro Glu Asn 
        435                 440                 445             


Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met Ser Met Pro 
    450                 455                 460                 


Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala Gly Gly Asp 
465                 470                 475                 480 


Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg Ile Ser Lys 
                485                 490                 495     


Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe Cys Arg Arg 
            500                 505                 510         


Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp Leu Val Ile 
        515                 520                 525             


Phe Leu Val Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu His Tyr Asn 
    530                 535                 540                 


Gln Pro Asn Trp Leu Thr Glu Val Gln Asp Thr Ala Asn Lys Ala Leu 
545                 550                 555                 560 


Leu Ala Leu Phe Thr Ala Glu Met Leu Leu Lys Met Tyr Ser Leu Gly 
                565                 570                 575     


Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp Cys Phe Val 
            580                 585                 590         


Val Cys Gly Gly Ile Leu Glu Thr Ile Leu Val Glu Thr Lys Ile Met 
        595                 600                 605             


Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu Leu Arg Ile 
    610                 615                 620                 


Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu Ser Asn Leu Val Ala Ser 
625                 630                 635                 640 


Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu Leu Leu Phe 
                645                 650                 655     


Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu Phe Gly Gly 
            660                 665                 670         


Lys Phe Asn Phe Asp Glu Met Gln Thr Arg Arg Ser Thr Phe Asp Asn 
        675                 680                 685             


Phe Pro Gln Ser Leu Leu Thr Val Phe Gln Ile Leu Thr Gly Glu Asp 
    690                 695                 700                 


Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly Gly Pro Ser 
705                 710                 715                 720 


Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu Phe Ile Cys 
                725                 730                 735     


Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn 
            740                 745                 750         


Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala Gln Lys Glu Glu Glu Glu 
        755                 760                 765             


Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr Ala Ser Pro Glu Lys Lys 
    770                 775                 780                 


Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys Glu Glu Lys 
785                 790                 795                 800 


Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly Glu Ser Pro Pro Ala Thr 
                805                 810                 815     


Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu Asp Lys Ser 
            820                 825                 830         


Pro Tyr Pro Asn Pro Glu Thr Thr Gly Glu Glu Asp Glu Glu Glu Pro 
        835                 840                 845             


Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu Leu His Leu 
    850                 855                 860                 


Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe Phe Ile Phe 
865                 870                 875                 880 


Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile Val Asn Asp 
                885                 890                 895     


Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe Ile Leu Leu Ser Ser Ile 
            900                 905                 910         


Ser Leu Ala Ala Glu Asp Pro Val Gln His Thr Ser Phe Arg Asn His 
        915                 920                 925             


Ile Leu Phe Tyr Phe Asp Ile Val Phe Thr Thr Ile Phe Thr Ile Glu 
    930                 935                 940                 


Ile Ala Leu Lys Met Thr Ala Tyr Gly Ala Phe Leu His Lys Gly Ser 
945                 950                 955                 960 


Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val Val Ser Val 
                965                 970                 975     


Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn Val Val Lys 
            980                 985                 990         


Ile Leu Arg Val Leu Arg Val Leu  Arg Pro Leu Arg Ala  Ile Asn Arg 
        995                 1000                 1005             


Ala Lys  Gly Leu Lys His Val  Val Gln Cys Val Phe  Val Ala Ile 
    1010                 1015                 1020             


Arg Thr  Ile Gly Asn Ile Val  Ile Val Thr Thr Leu  Leu Gln Phe 
    1025                 1030                 1035             


Met Phe  Ala Cys Ile Gly Val  Gln Leu Phe Lys Gly  Lys Leu Tyr 
    1040                 1045                 1050             


Thr Cys  Ser Asp Ser Ser Lys  Gln Thr Glu Ala Glu  Cys Lys Gly 
    1055                 1060                 1065             


Asn Tyr  Ile Thr Tyr Lys Asp  Gly Glu Val Asp His  Pro Ile Ile 
    1070                 1075                 1080             


Gln Pro  Arg Ser Trp Glu Asn  Ser Lys Phe Asp Phe  Asp Asn Val 
    1085                 1090                 1095             


Leu Ala  Ala Met Met Ala Leu  Phe Thr Val Ser Thr  Phe Glu Gly 
    1100                 1105                 1110             


Trp Pro  Glu Leu Leu Tyr Arg  Ser Ile Asp Ser His  Thr Glu Asp 
    1115                 1120                 1125             


Lys Gly  Pro Ile Tyr Asn Tyr  Arg Val Glu Ile Ser  Ile Phe Phe 
    1130                 1135                 1140             


Ile Ile  Tyr Ile Ile Ile Ile  Ala Phe Phe Met Met  Asn Ile Phe 
    1145                 1150                 1155             


Val Gly  Phe Val Ile Val Thr  Phe Gln Glu Gln Gly  Glu Gln Glu 
    1160                 1165                 1170             


Tyr Lys  Asn Cys Glu Leu Asp  Lys Asn Gln Arg Gln  Cys Val Glu 
    1175                 1180                 1185             


Tyr Ala  Leu Lys Ala Arg Pro  Leu Arg Arg Tyr Ile  Pro Lys Asn 
    1190                 1195                 1200             


Gln His  Gln Tyr Lys Val Trp  Tyr Val Val Asn Ser  Thr Tyr Phe 
    1205                 1210                 1215             


Glu Tyr  Leu Met Phe Val Leu  Ile Leu Leu Asn Thr  Ile Cys Leu 
    1220                 1225                 1230             


Ala Met  Gln His Tyr Gly Gln  Ser Cys Leu Phe Lys  Ile Ala Met 
    1235                 1240                 1245             


Asn Ile  Leu Asn Met Leu Phe  Thr Gly Leu Phe Thr  Val Glu Met 
    1250                 1255                 1260             


Ile Leu  Lys Leu Ile Ala Phe  Lys Pro Lys Gly Tyr  Phe Ser Asp 
    1265                 1270                 1275             


Pro Trp  Asn Val Phe Asp Phe  Leu Ile Val Ile Gly  Ser Ile Ile 
    1280                 1285                 1290             


Asp Val  Ile Leu Ser Glu Thr  Asn Pro Ala Glu His  Thr Gln Cys 
    1295                 1300                 1305             


Ser Pro  Ser Met Asn Ala Glu  Glu Asn Ser Arg Ile  Ser Ile Thr 
    1310                 1315                 1320             


Phe Phe  Arg Leu Phe Arg Val  Met Arg Leu Val Lys  Leu Leu Ser 
    1325                 1330                 1335             


Arg Gly  Glu Gly Ile Arg Thr  Leu Leu Trp Thr Phe  Ile Lys Ser 
    1340                 1345                 1350             


Phe Gln  Ala Leu Pro Tyr Val  Ala Leu Leu Ile Val  Met Leu Phe 
    1355                 1360                 1365             


Phe Ile  Tyr Ala Val Ile Gly  Met Gln Val Phe Gly  Lys Ile Ala 
    1370                 1375                 1380             


Leu Asn  Asp Thr Thr Glu Ile  Asn Arg Asn Asn Asn  Phe Gln Thr 
    1385                 1390                 1395             


Phe Pro  Gln Ala Val Leu Leu  Leu Phe Arg Cys Ala  Thr Gly Glu 
    1400                 1405                 1410             


Ala Trp  Gln Asp Ile Met Leu  Ala Cys Met Pro Gly  Lys Lys Cys 
    1415                 1420                 1425             


Ala Pro  Glu Ser Glu Pro Ser  Asn Ser Thr Glu Gly  Glu Thr Pro 
    1430                 1435                 1440             


Cys Gly  Ser Ser Phe Ala Val  Phe Tyr Phe Ile Ser  Phe Tyr Met 
    1445                 1450                 1455             


Leu Cys  Ala Phe Leu Ile Ile  Asn Leu Phe Val Ala  Val Ile Met 
    1460                 1465                 1470             


Asp Asn  Phe Asp Tyr Leu Thr  Arg Asp Trp Ser Ile  Leu Gly Pro 
    1475                 1480                 1485             


His His  Leu Asp Glu Phe Lys  Arg Ile Trp Ala Glu  Tyr Asp Pro 
    1490                 1495                 1500             


Glu Ala  Lys Gly Arg Ile Lys  His Leu Asp Val Val  Thr Leu Leu 
    1505                 1510                 1515             


Arg Arg  Ile Gln Pro Pro Leu  Gly Phe Gly Lys Leu  Cys Pro His 
    1520                 1525                 1530             


Arg Val  Ala Cys Lys Arg Leu  Val Ser Met Asn Met  Pro Leu Asn 
    1535                 1540                 1545             


Ser Asp  Gly Thr Val Met Phe  Asn Ala Thr Leu Phe  Ala Leu Val 
    1550                 1555                 1560             


Arg Thr  Ala Leu Arg Ile Lys  Thr Glu Gly Asn Leu  Glu Gln Ala 
    1565                 1570                 1575             


Asn Glu  Glu Leu Arg Ala Ile  Ile Lys Lys Ile Trp  Lys Arg Thr 
    1580                 1585                 1590             


Ser Met  Lys Leu Leu Asp Gln  Val Val Pro Pro Ala  Gly Asp Asp 
    1595                 1600                 1605             


Glu Val  Thr Val Gly Lys Phe  Tyr Ala Thr Phe Leu  Ile Gln Glu 
    1610                 1615                 1620             


Tyr Phe  Arg Lys Phe Lys Lys  Arg Lys Glu Gln Gly  Leu Val Gly 
    1625                 1630                 1635             


Lys Pro  Ser Gln Arg Asn Ala  Leu Ser Leu Gln Ala  Gly Leu Arg 
    1640                 1645                 1650             


Thr Leu  His Asp Ile Gly Pro  Glu Ile Arg Arg Ala  Ile Ser Gly 
    1655                 1660                 1665             


Asp Leu  Thr Ala Glu Glu Glu  Leu Asp Lys Ala Met  Lys Glu Ala 
    1670                 1675                 1680             


Val Ser  Ala Ala Ser Glu Asp  Asp Ile Phe Arg Arg  Ala Gly Gly 
    1685                 1690                 1695             


Leu Phe  Gly Asn His Val Ser  Tyr Tyr Gln Ser Asp  Gly Arg Ser 
    1700                 1705                 1710             


Ala Phe  Pro Gln Thr Phe Thr  Thr Gln Arg Pro Leu  His Ile Asn 
    1715                 1720                 1725             


Lys Ala  Gly Ser Ser Gln Gly  Asp Thr Glu Ser Pro  Ser His Glu 
    1730                 1735                 1740             


Lys Leu  Val Asp Ser Thr Phe  Thr Pro Ser Ser Tyr  Ser Ser Thr 
    1745                 1750                 1755             


Gly Ser  Asn Ala Asn Ile Asn  Asn Ala Asn Asn Thr  Ala Leu Gly 
    1760                 1765                 1770             


Arg Leu  Pro Arg Pro Ala Gly  Tyr Pro Ser Thr Val  Ser Thr Val 
    1775                 1780                 1785             


Glu Gly  His Gly Pro Pro Leu  Ser Pro Ala Ile Arg  Val Gln Glu 
    1790                 1795                 1800             


Val Ala  Trp Lys Leu Ser Ser  Asn Arg Cys His Ser  Arg Glu Ser 
    1805                 1810                 1815             


Gln Ala  Ala Met Ala Gly Gln  Glu Glu Thr Ser Gln  Asp Glu Thr 
    1820                 1825                 1830             


Tyr Glu  Val Lys Met Asn His  Asp Thr Glu Ala Cys  Ser Glu Pro 
    1835                 1840                 1845             


Ser Leu  Leu Ser Thr Glu Met  Leu Ser Tyr Gln Asp  Asp Glu Asn 
    1850                 1855                 1860             


Arg Gln  Leu Thr Leu Pro Glu  Glu Asp Lys Arg Asp  Ile Arg Gln 
    1865                 1870                 1875             


Ser Pro  Lys Arg Gly Phe Leu  Arg Ser Ala Ser Leu  Gly Arg Arg 
    1880                 1885                 1890             


Ala Ser  Phe His Leu Glu Cys  Leu Lys Arg Gln Lys  Asp Arg Gly 
    1895                 1900                 1905             


Gly Asp  Ile Ser Gln Lys Thr  Val Leu Pro Leu His  Leu Val His 
    1910                 1915                 1920             


His Gln  Ala Leu Ala Val Ala  Gly Leu Ser Pro Leu  Leu Gln Arg 
    1925                 1930                 1935             


Ser His  Ser Pro Ala Ser Phe  Pro Arg Pro Phe Ala  Thr Pro Pro 
    1940                 1945                 1950             


Ala Thr  Pro Gly Ser Arg Gly  Trp Pro Pro Gln Pro  Val Pro Thr 
    1955                 1960                 1965             


Leu Arg  Leu Glu Gly Val Glu  Ser Ser Glu Lys Leu  Asn Ser Ser 
    1970                 1975                 1980             


Phe Pro  Ser Ile His Cys Gly  Ser Trp Ala Glu Thr  Thr Pro Gly 
    1985                 1990                 1995             


Gly Gly  Gly Ser Ser Ala Ala  Arg Arg Val Arg Pro  Val Ser Leu 
    2000                 2005                 2010             


Met Val  Pro Ser Gln Ala Gly  Ala Pro Gly Arg Gln  Phe His Gly 
    2015                 2020                 2025             


Ser Ala  Ser Ser Leu Val Glu  Ala Val Leu Ile Ser  Glu Gly Leu 
    2030                 2035                 2040             


Gly Gln  Phe Ala Gln Asp Pro  Lys Phe Ile Glu Val  Thr Thr Gln 
    2045                 2050                 2055             


Glu Leu  Ala Asp Ala Cys Asp  Met Thr Ile Glu Glu  Met Glu Ser 
    2060                 2065                 2070             


Ala Ala  Asp Asn Ile Leu Ser  Gly Gly Ala Pro Gln  Ser Pro Asn 
    2075                 2080                 2085             


Gly Ala  Leu Leu Pro Phe Val  Asn Cys Arg Asp Ala  Gly Gln Asp 
    2090                 2095                 2100             


Arg Ala  Gly Gly Glu Glu Asp  Ala Gly Cys Val Arg  Ala Arg Gly 
    2105                 2110                 2115             


Arg Pro  Ser Glu Glu Glu Leu  Gln Asp Ser Arg Val  Tyr Val Ser 
    2120                 2125                 2130             


Ser Leu  
    2135 


<210>  1401
<211>  2127
<212>  PRT
<213>  Homo sapiens

<400>  1401

Met Val Asn Glu Asn Thr Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser Thr Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Thr Thr 
                85                  90                  95      


Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Thr 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Thr Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Thr Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Thr Glu Val Gln Asp Thr Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Thr Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr Ile Leu Val Glu Thr 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Thr Arg Arg Ser Thr 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Thr Val Phe Gln Ile Leu Thr 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Thr Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Thr Thr Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Thr Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Gly Asn Ala Asp Tyr Val Phe Thr Ser Ile Phe 
    930                 935                 940                 


Thr Leu Glu Ile Ile Leu Lys Met Thr Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Thr Ile Gly  Asn Ile Val Ile Val  Thr Thr Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Thr Cys Ser Asp  Ser Ser Lys Gln Thr  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Thr  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Thr  Val Ser Thr 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Thr Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Thr Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Thr Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Thr 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Thr Gly  Leu Phe Thr 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys His Tyr 
    1265                 1270                 1275             


Phe Cys  Asp Ala Trp Asn Thr  Phe Asp Ala Leu Ile  Val Val Gly 
    1280                 1285                 1290             


Ser Ile  Val Asp Ile Ala Ile  Thr Glu Val Asn Asn  Ala Glu Glu 
    1295                 1300                 1305             


Asn Ser  Arg Ile Ser Ile Thr  Phe Phe Arg Leu Phe  Arg Val Met 
    1310                 1315                 1320             


Arg Leu  Val Lys Leu Leu Ser  Arg Gly Glu Gly Ile  Arg Thr Leu 
    1325                 1330                 1335             


Leu Trp  Thr Phe Ile Lys Ser  Phe Gln Ala Leu Pro  Tyr Val Ala 
    1340                 1345                 1350             


Leu Leu  Ile Val Met Leu Phe  Phe Ile Tyr Ala Val  Ile Gly Met 
    1355                 1360                 1365             


Gln Val  Phe Gly Lys Ile Ala  Leu Asn Asp Thr Thr  Glu Ile Asn 
    1370                 1375                 1380             


Arg Asn  Asn Asn Phe Gln Thr  Phe Pro Gln Ala Val  Leu Leu Leu 
    1385                 1390                 1395             


Phe Arg  Cys Ala Thr Gly Glu  Ala Trp Gln Asp Ile  Met Leu Ala 
    1400                 1405                 1410             


Cys Met  Pro Gly Lys Lys Cys  Ala Pro Glu Ser Glu  Pro Ser Asn 
    1415                 1420                 1425             


Ser Thr  Glu Gly Glu Thr Pro  Cys Gly Ser Ser Phe  Ala Val Phe 
    1430                 1435                 1440             


Tyr Phe  Ile Ser Phe Tyr Met  Leu Cys Ala Phe Leu  Ile Ile Asn 
    1445                 1450                 1455             


Leu Phe  Val Ala Val Ile Met  Asp Asn Phe Asp Tyr  Leu Thr Arg 
    1460                 1465                 1470             


Asp Trp  Ser Ile Leu Gly Pro  His His Leu Asp Glu  Phe Lys Arg 
    1475                 1480                 1485             


Ile Trp  Ala Glu Tyr Asp Pro  Glu Ala Lys Gly Arg  Ile Lys His 
    1490                 1495                 1500             


Leu Asp  Val Val Thr Leu Leu  Arg Arg Ile Gln Pro  Pro Leu Gly 
    1505                 1510                 1515             


Phe Gly  Lys Leu Cys Pro His  Arg Val Ala Cys Lys  Arg Leu Val 
    1520                 1525                 1530             


Ser Met  Asn Met Pro Leu Asn  Ser Asp Gly Thr Val  Met Phe Asn 
    1535                 1540                 1545             


Ala Thr  Leu Phe Ala Leu Val  Arg Thr Ala Leu Arg  Ile Lys Thr 
    1550                 1555                 1560             


Glu Gly  Asn Leu Glu Gln Ala  Asn Glu Glu Leu Arg  Ala Ile Ile 
    1565                 1570                 1575             


Lys Lys  Ile Trp Lys Arg Thr  Ser Met Lys Leu Leu  Asp Gln Val 
    1580                 1585                 1590             


Val Pro  Pro Ala Gly Asp Asp  Glu Val Thr Val Gly  Lys Phe Tyr 
    1595                 1600                 1605             


Ala Thr  Phe Leu Ile Gln Glu  Tyr Phe Arg Lys Phe  Lys Lys Arg 
    1610                 1615                 1620             


Lys Glu  Gln Gly Leu Val Gly  Lys Pro Ser Gln Arg  Asn Ala Leu 
    1625                 1630                 1635             


Ser Leu  Gln Ala Gly Leu Arg  Thr Leu His Asp Ile  Gly Pro Glu 
    1640                 1645                 1650             


Ile Arg  Arg Ala Ile Ser Gly  Asp Leu Thr Ala Glu  Glu Glu Leu 
    1655                 1660                 1665             


Asp Lys  Ala Met Lys Glu Ala  Val Ser Ala Ala Ser  Glu Asp Asp 
    1670                 1675                 1680             


Ile Phe  Arg Arg Ala Gly Gly  Leu Phe Gly Asn His  Val Ser Tyr 
    1685                 1690                 1695             


Tyr Gln  Ser Asp Gly Arg Ser  Ala Phe Pro Gln Thr  Phe Thr Thr 
    1700                 1705                 1710             


Gln Arg  Pro Leu His Ile Asn  Lys Ala Gly Ser Ser  Gln Gly Asp 
    1715                 1720                 1725             


Thr Glu  Ser Pro Ser His Glu  Lys Leu Val Asp Ser  Thr Phe Thr 
    1730                 1735                 1740             


Pro Ser  Ser Tyr Ser Ser Thr  Gly Ser Asn Ala Asn  Ile Asn Asn 
    1745                 1750                 1755             


Ala Asn  Asn Thr Ala Leu Gly  Arg Leu Pro Arg Pro  Ala Gly Tyr 
    1760                 1765                 1770             


Pro Ser  Thr Val Ser Thr Val  Glu Gly His Gly Pro  Pro Leu Ser 
    1775                 1780                 1785             


Pro Ala  Ile Arg Val Gln Glu  Val Ala Trp Lys Leu  Ser Ser Asn 
    1790                 1795                 1800             


Arg Cys  His Ser Arg Glu Ser  Gln Ala Ala Met Ala  Gly Gln Glu 
    1805                 1810                 1815             


Glu Thr  Ser Gln Asp Glu Thr  Tyr Glu Val Lys Met  Asn His Asp 
    1820                 1825                 1830             


Thr Glu  Ala Cys Ser Glu Pro  Ser Leu Leu Ser Thr  Glu Met Leu 
    1835                 1840                 1845             


Ser Tyr  Gln Asp Asp Glu Asn  Arg Gln Leu Thr Leu  Pro Glu Glu 
    1850                 1855                 1860             


Asp Lys  Arg Asp Ile Arg Gln  Ser Pro Lys Arg Gly  Phe Leu Arg 
    1865                 1870                 1875             


Ser Ala  Ser Leu Gly Arg Arg  Ala Ser Phe His Leu  Glu Cys Leu 
    1880                 1885                 1890             


Lys Arg  Gln Lys Asp Arg Gly  Gly Asp Ile Ser Gln  Lys Thr Val 
    1895                 1900                 1905             


Leu Pro  Leu His Leu Val His  His Gln Ala Leu Ala  Val Ala Gly 
    1910                 1915                 1920             


Leu Ser  Pro Leu Leu Gln Arg  Ser His Ser Pro Ala  Ser Phe Pro 
    1925                 1930                 1935             


Arg Pro  Phe Ala Thr Pro Pro  Ala Thr Pro Gly Ser  Arg Gly Trp 
    1940                 1945                 1950             


Pro Pro  Gln Pro Val Pro Thr  Leu Arg Leu Glu Gly  Val Glu Ser 
    1955                 1960                 1965             


Ser Glu  Lys Leu Asn Ser Ser  Phe Pro Ser Ile His  Cys Gly Ser 
    1970                 1975                 1980             


Trp Ala  Glu Thr Thr Pro Gly  Gly Gly Gly Ser Ser  Ala Ala Arg 
    1985                 1990                 1995             


Arg Val  Arg Pro Val Ser Leu  Met Val Pro Ser Gln  Ala Gly Ala 
    2000                 2005                 2010             


Pro Gly  Arg Gln Phe His Gly  Ser Ala Ser Ser Leu  Val Glu Ala 
    2015                 2020                 2025             


Val Leu  Ile Ser Glu Gly Leu  Gly Gln Phe Ala Gln  Asp Pro Lys 
    2030                 2035                 2040             


Phe Ile  Glu Val Thr Thr Gln  Glu Leu Ala Asp Ala  Cys Asp Met 
    2045                 2050                 2055             


Thr Ile  Glu Glu Met Glu Ser  Ala Ala Asp Asn Ile  Leu Ser Gly 
    2060                 2065                 2070             


Gly Ala  Pro Gln Ser Pro Asn  Gly Ala Leu Leu Pro  Phe Val Asn 
    2075                 2080                 2085             


Cys Arg  Asp Ala Gly Gln Asp  Arg Ala Gly Gly Glu  Glu Asp Ala 
    2090                 2095                 2100             


Gly Cys  Val Arg Ala Arg Gly  Arg Pro Ser Glu Glu  Glu Leu Gln 
    2105                 2110                 2115             


Asp Ser  Arg Val Tyr Val Ser  Ser Leu 
    2120                 2125         


<210>  1402
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  1402

Met Ser Asp Leu Leu Leu Leu Gly Leu Ile Gly Gly Leu Thr Leu Leu 
1               5                   10                  15      


Leu Leu Leu Thr Leu Leu Ala Phe Ala Gly Tyr Ser Gly Leu Leu Ala 
            20                  25                  30          


Gly Val Glu Val Ser Ala Gly Ser Pro Pro Ile Arg Asn Val Thr Val 
        35                  40                  45              


Ala Tyr Lys Phe His Met Gly Leu Tyr Gly Glu Thr Gly Arg Leu Phe 
    50                  55                  60                  


Thr Glu Ser Cys Ser Ile Ser Pro Lys Leu Arg Ser Ile Ala Val Tyr 
65                  70                  75                  80  


Tyr Asp Asn Pro His Met Val Pro Pro Asp Lys Cys Arg Cys Ala Val 
                85                  90                  95      


Gly Ser Ile Leu Ser Glu Gly Glu Glu Ser Pro Ser Pro Glu Leu Ile 
            100                 105                 110         


Asp Leu Tyr Gln Lys Phe Gly Phe Lys Val Phe Ser Phe Pro Ala Pro 
        115                 120                 125             


Ser His Val Val Thr Ala Thr Phe Pro Tyr Thr Thr Ile Leu Ser Ile 
    130                 135                 140                 


Trp Leu Ala Thr Arg Arg Val His Pro Ala Leu Asp Thr Tyr Ile Lys 
145                 150                 155                 160 


Glu Arg Lys Leu Cys Ala Tyr Pro Arg Leu Glu Ile Tyr Gln Glu Asp 
                165                 170                 175     


Gln Ile His Phe Met Cys Pro Leu Ala Arg Gln Gly Asp Phe Tyr Val 
            180                 185                 190         


Pro Glu Met Lys Glu Thr Glu Trp Lys Trp Arg Gly Leu Val Glu Ala 
        195                 200                 205             


Ile Asp Thr Gln Val Asp Gly Thr Gly Ala Asp Thr Met Ser Asp Thr 
    210                 215                 220                 


Ser Ser Val Ser Leu Glu Val Ser Pro Gly Ser Arg Glu Thr Ser Ala 
225                 230                 235                 240 


Ala Thr Leu Ser Pro Gly Ala Ser Ser Arg Gly Trp Asp Asp Gly Asp 
                245                 250                 255     


Thr Arg Ser Glu His Ser Tyr Ser Glu Ser Gly Ala Ser Gly Ser Ser 
            260                 265                 270         


Phe Glu Glu Leu Asp Leu Glu Gly Glu Gly Pro Leu Gly Glu Ser Arg 
        275                 280                 285             


Leu Asp Pro Gly Thr Glu Pro Leu Gly Thr Thr Lys Trp Leu Trp Glu 
    290                 295                 300                 


Pro Thr Ala Pro Glu Lys Gly Lys Glu 
305                 310             


<210>  1403
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  1403

Met Ala Pro Lys Pro Gly Ala Glu Trp Ser Thr Ala Leu Ser His Leu 
1               5                   10                  15      


Val Leu Gly Val Val Ser Leu His Ala Ala Val Ser Thr Ala Glu Ala 
            20                  25                  30          


Ser Arg Gly Ala Ala Ala Gly Phe Leu Leu Gln Val Leu Ala Ala Thr 
        35                  40                  45              


Thr Thr Leu Ala Pro Gly Leu Ser Thr His Glu Asp Cys Leu Ala Gly 
    50                  55                  60                  


Ala Trp Val Ala Thr Val Ile Gly Leu Pro Leu Leu Ala Phe Asp Phe 
65                  70                  75                  80  


His Trp Val Asn Gly Asp Arg Ser Ser Ala Asn Leu Leu Leu Gly Gly 
                85                  90                  95      


Gly Met Val Leu Ala Val Ala Gly Gly His Leu Gly Pro Glu Gly Arg 
            100                 105                 110         


Ser Val Ala Gly Gln Ala Met Leu Leu Val Val Ala Val Thr Ile Leu 
        115                 120                 125             


Ile Val Ala Val Phe Thr Ala Asn Thr Tyr Gly Met Trp Gly Gly Ala 
    130                 135                 140                 


Met Leu Gly Val Ala Gly Leu Leu Ser Arg Leu Glu Glu Asp Arg Leu 
145                 150                 155                 160 


Leu Leu Leu Pro Lys Glu Asp Val Cys Arg Trp Ala Leu Ala Val Gly 
                165                 170                 175     


Ser Trp Ala Tyr Cys Arg Ala Leu His Thr Gln Arg Leu Gln Trp Glu 
            180                 185                 190         


<210>  1404
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  1404

Met Ser Pro Leu Trp Trp Gly Phe Leu Leu Ser Cys Leu Gly Cys Lys 
1               5                   10                  15      


Ile Leu Pro Gly Ala Gln Gly Gln Phe Pro Arg Val Cys Met Thr Val 
            20                  25                  30          


Asp Ser Leu Val Asn Lys Glu Cys Cys Pro Arg Leu Gly Ala Glu Ser 
        35                  40                  45              


Ala Asn Val Cys Gly Ser Gln Gln Gly Arg Gly Gln Cys Thr Glu Val 
    50                  55                  60                  


Arg Ala Asp Thr Arg Pro Trp Ser Gly Pro Tyr Ile Leu Arg Asn Gln 
65                  70                  75                  80  


Asp Asp Arg Glu Leu Trp Pro Arg Lys Phe Phe His Arg Thr Cys Lys 
                85                  90                  95      


Cys Thr Gly Asn Phe Ala Gly Tyr Asn Cys Gly Asp Cys Lys Phe Gly 
            100                 105                 110         


Trp Thr Gly Pro Asn Cys Glu Arg Lys Lys Pro Pro Val Ile Arg Gln 
        115                 120                 125             


Asn Ile His Ser Leu Ser Pro Gln Glu Arg Glu Gln Phe Leu Gly Ala 
    130                 135                 140                 


Leu Asp Leu Ala Lys Lys Arg Val His Pro Asp Tyr Val Ile Thr Thr 
145                 150                 155                 160 


Gln His Trp Leu Gly Leu Leu Gly Pro Asn Gly Thr Gln Pro Gln Phe 
                165                 170                 175     


Ala Asn Cys Ser Val Tyr Asp Phe Phe Val Trp Leu His Tyr Tyr Ser 
            180                 185                 190         


Val Arg Asp Thr Leu Leu Gly Pro Gly Arg Pro Tyr Arg Ala Ile Asp 
        195                 200                 205             


Phe Ser His Gln Gly Pro Ala Phe Val Thr Trp His Arg Tyr His Leu 
    210                 215                 220                 


Leu Cys Leu Glu Arg Asp Leu Gln Arg Leu Ile Gly Asn Glu Ser Phe 
225                 230                 235                 240 


Ala Leu Pro Tyr Trp Asn Phe Ala Thr Gly Arg Asn Glu Cys Asp Val 
                245                 250                 255     


Cys Thr Asp Gln Leu Phe Gly Ala Ala Arg Pro Asp Asp Pro Thr Leu 
            260                 265                 270         


Ile Ser Arg Asn Ser Arg Phe Ser Ser Trp Glu Thr Val Cys Asp Ser 
        275                 280                 285             


Leu Asp Asp Tyr Asn His Leu Val Thr Leu Cys Asn Gly Thr Tyr Glu 
    290                 295                 300                 


Gly Leu Leu Arg Arg Asn Gln Met Gly Arg Asn Ser Met Lys Leu Pro 
305                 310                 315                 320 


Thr Leu Lys Asp Ile Arg Asp Cys Leu Ser Leu Gln Lys Phe Asp Asn 
                325                 330                 335     


Pro Pro Phe Phe Gln Asn Ser Thr Phe Ser Phe Arg Asn Ala Leu Glu 
            340                 345                 350         


Gly Phe Asp Lys Ala Asp Gly Thr Leu Asp Ser Gln Val Met Ser Leu 
        355                 360                 365             


His Asn Leu Val His Ser Phe Leu Asn Gly Thr Asn Ala Leu Pro His 
    370                 375                 380                 


Ser Ala Ala Asn Asp Pro Ile Phe Val Val Ile Ser Asn Arg Leu Leu 
385                 390                 395                 400 


Tyr Asn Ala Thr Thr Asn Ile Leu Glu His Val Arg Lys Glu Lys Ala 
                405                 410                 415     


Thr Lys Glu Leu Pro Ser Leu His Val Leu Val Leu His Ser Phe Thr 
            420                 425                 430         


Asp Ala Ile Phe Asp Glu Trp Met Lys Arg Phe Asn Pro Pro Ala Asp 
        435                 440                 445             


Ala Trp Pro Gln Glu Leu Ala Pro Ile Gly His Asn Arg Met Tyr Asn 
    450                 455                 460                 


Met Val Pro Phe Phe Pro Pro Val Thr Asn Glu Glu Leu Phe Leu Thr 
465                 470                 475                 480 


Ser Asp Gln Leu Gly Tyr Ser Tyr Ala Ile Asp Leu Pro Val Ser Val 
                485                 490                 495     


Glu Glu Thr Pro Gly Trp Pro Thr Thr Leu Leu Val Val Met Gly Thr 
            500                 505                 510         


Leu Val Ala Leu Val Gly Leu Phe Val Leu Leu Ala Phe Leu Gln Tyr 
        515                 520                 525             


Arg Arg Leu Arg Lys Gly Tyr Thr Pro Leu Met Glu Thr His Leu Ser 
    530                 535                 540                 


Ser Lys Arg Tyr Thr Glu Glu Ala 
545                 550         


<210>  1405
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  1405

Met Ala Ser Trp Leu Arg Arg Lys Leu Arg Gly Lys Arg Arg Pro Val 
1               5                   10                  15      


Ile Ala Phe Cys Leu Leu Met Ile Leu Ser Ala Met Ala Val Thr Arg 
            20                  25                  30          


Phe Pro Pro Gln Arg Pro Ser Ala Gly Pro Asp Pro Gly Pro Met Glu 
        35                  40                  45              


Pro Gln Gly Val Thr Gly Ala Pro Ala Thr His Ile Arg Gln Ala Leu 
    50                  55                  60                  


Ser Ser Ser Arg Arg Gln Arg Ala Arg Asn Met Gly Phe Trp Arg Ser 
65                  70                  75                  80  


Arg Ala Leu Pro Arg Asn Ser Ile Leu Val Cys Ala Glu Glu Gln Gly 
                85                  90                  95      


His Arg Ala Arg Val Asp Arg Ser Arg Glu Ser Pro Gly Gly Asp Leu 
            100                 105                 110         


Arg His Pro Gly Arg Val Arg Arg Asp Ile Thr Leu Ser Gly His Pro 
        115                 120                 125             


Arg Leu Ser Thr Gln His Val Val Leu Leu Arg Glu Asp Glu Val Gly 
    130                 135                 140                 


Asp Pro Gly Thr Lys Asp Leu Gly His Pro Gln His Gly Ser Pro Ile 
145                 150                 155                 160 


Gln Glu Thr Gln Ser Glu Val Val Thr Leu Val Ser Pro Leu Pro Gly 
                165                 170                 175     


Ser Asp Met Ala Ala Leu Pro Ala Trp Arg Ala Thr Ser Gly Leu Thr 
            180                 185                 190         


Leu Trp Pro His Thr Ala Glu Gly Arg Asp Leu Leu Gly Ala Glu Asn 
        195                 200                 205             


Arg Ala Leu Thr Gly Gly Gln Gln Ala Glu Asp Pro Thr Leu Ala Ser 
    210                 215                 220                 


Gly Ala His Gln Trp Pro Gly Ser Val Glu Lys Leu Gln Gly Ser Val 
225                 230                 235                 240 


Trp Cys Asp Ala Glu Thr Leu Leu Ser Ser Ser Arg Thr Gly Gly Gln 
                245                 250                 255     


Ala Pro Pro Trp Leu Thr Asp His Asp Val Gln Met Leu Arg Leu Leu 
            260                 265                 270         


Ala Gln Gly Glu Val Val Asp Lys Ala Arg Val Pro Ala His Gly Gln 
        275                 280                 285             


Val Leu Gln Val Gly Phe Ser Thr Glu Ala Ala Leu Gln Asp Leu Ser 
    290                 295                 300                 


Ser Pro Arg Leu Ser Gln Leu Cys Ser Gln Gly Leu Cys Gly Leu Ile 
305                 310                 315                 320 


Lys Arg Pro Gly Asp Leu Pro Glu Val Leu Ser Phe His Val Asp Arg 
                325                 330                 335     


Val Leu Gly Leu Arg Arg Ser Leu Pro Ala Val Ala Arg Arg Phe His 
            340                 345                 350         


Ser Pro Leu Leu Pro Tyr Arg Tyr Thr Asp Gly Gly Ala Arg Pro Val 
        355                 360                 365             


Ile Trp Trp Ala Pro Asp Val Gln His Leu Ser Asp Pro Asp Glu Asp 
    370                 375                 380                 


Gln Asn Ser Leu Ala Leu Gly Trp Leu Gln Tyr Gln Ala Leu Leu Ala 
385                 390                 395                 400 


His Ser Cys Asn Trp Pro Gly Gln Ala Pro Cys Pro Gly Ile His His 
                405                 410                 415     


Thr Glu Trp Ala Arg Leu Ala Leu Phe Asp Phe Leu Leu Gln Val His 
            420                 425                 430         


Asp Arg Leu Asp Arg Tyr Cys Cys Gly Phe Glu Pro Glu Pro Ser Asp 
        435                 440                 445             


Pro Cys Val Glu Glu Arg Leu Arg Glu Lys Cys Gln Asn Pro Ala Glu 
    450                 455                 460                 


Leu Arg Leu Val His Ile Leu Val Arg Ser Ser Asp Pro Ser His Leu 
465                 470                 475                 480 


Val Tyr Ile Asp Asn Ala Gly Asn Leu Gln His Pro Glu Asp Lys Leu 
                485                 490                 495     


Asn Phe Arg Leu Leu Glu Gly Ile Asp Gly Phe Pro Glu Ser Ala Val 
            500                 505                 510         


Lys Val Leu Ala Ser Gly Cys Leu Gln Asn Met Leu Leu Lys Ser Leu 
        515                 520                 525             


Gln Met Asp Pro Val Phe Trp Glu Ser Gln Gly Gly Ala Gln Gly Leu 
    530                 535                 540                 


Lys Gln Val Leu Gln Thr Leu Glu Gln Arg Gly Gln Val Leu Leu Gly 
545                 550                 555                 560 


His Ile Gln Lys His Asn Leu Thr Leu Phe Arg Asp Glu Asp Pro 
                565                 570                 575 


<210>  1406
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  1406

Met Trp Ile Asp Phe Phe Thr Tyr Ser Ser Met Ser Glu Glu Val Thr 
1               5                   10                  15      


Tyr Ala Asp Leu Gln Phe Gln Asn Ser Ser Glu Met Glu Lys Ile Pro 
            20                  25                  30          


Glu Ile Gly Lys Phe Gly Glu Lys Ala Pro Pro Ala Pro Ser His Val 
        35                  40                  45              


Trp Arg Pro Ala Ala Leu Phe Leu Thr Leu Leu Cys Leu Leu Leu Leu 
    50                  55                  60                  


Ile Gly Leu Gly Val Leu Ala Ser Met Phe His Val Thr Leu Lys Ile 
65                  70                  75                  80  


Glu Met Lys Lys Met Asn Lys Leu Gln Asn Ile Ser Glu Glu Leu Gln 
                85                  90                  95      


Arg Asn Ile Ser Leu Gln Leu Met Ser Asn Met Asn Ile Ser Asn Lys 
            100                 105                 110         


Ile Arg Asn Leu Ser Thr Thr Leu Gln Thr Ile Ala Thr Lys Leu Cys 
        115                 120                 125             


Arg Glu Leu Tyr Ser Lys Glu Gln Glu His Lys Cys Lys Pro Cys Pro 
    130                 135                 140                 


Arg Arg Trp Ile Trp His Lys Asp Ser Cys Tyr Phe Leu Ser Asp Asp 
145                 150                 155                 160 


Val Gln Thr Trp Gln Glu Ser Lys Met Ala Cys Ala Ala Gln Asn Ala 
                165                 170                 175     


Ser Leu Leu Lys Ile Asn Asn Lys Asn Ala Leu Glu Phe Ile Lys Ser 
            180                 185                 190         


Gln Ser Arg Ser Tyr Asp Tyr Trp Leu Gly Leu Ser Pro Glu Glu Asp 
        195                 200                 205             


Ser Thr Arg Gly Met Arg Val Asp Asn Ile Ile Asn Ser Ser Ala Trp 
    210                 215                 220                 


Val Ile Arg Asn Ala Pro Asp Leu Asn Asn Met Tyr Cys Gly Tyr Ile 
225                 230                 235                 240 


Asn Arg Leu Tyr Val Gln Tyr Tyr His Cys Thr Tyr Lys Lys Arg Met 
                245                 250                 255     


Ile Cys Glu Lys Met Ala Asn Pro Val Gln Leu Gly Ser Thr Tyr Phe 
            260                 265                 270         


Arg Glu Ala 
        275 


<210>  1407
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  1407

Met Ser Glu Glu Val Thr Tyr Ala Thr Leu Thr Phe Gln Asp Ser Ala 
1               5                   10                  15      


Gly Ala Arg Asn Asn Arg Asp Gly Asn Asn Leu Arg Lys Arg Gly His 
            20                  25                  30          


Pro Ala Pro Ser Pro Ile Trp Arg His Ala Ala Leu Gly Leu Val Thr 
        35                  40                  45              


Leu Cys Leu Met Leu Leu Ile Gly Leu Val Thr Leu Gly Met Met Phe 
    50                  55                  60                  


Leu Gln Ile Ser Asn Asp Ile Asn Ser Asp Ser Glu Lys Leu Ser Gln 
65                  70                  75                  80  


Leu Gln Lys Thr Ile Gln Gln Gln Gln Asp Asn Leu Ser Gln Gln Leu 
                85                  90                  95      


Gly Asn Ser Asn Asn Leu Ser Met Glu Glu Glu Phe Leu Lys Ser Gln 
            100                 105                 110         


Ile Ser Ser Val Leu Lys Arg Gln Glu Gln Met Ala Ile Lys Leu Cys 
        115                 120                 125             


Gln Glu Leu Ile Ile His Thr Ser Asp His Arg Cys Asn Pro Cys Pro 
    130                 135                 140                 


Lys Met Trp Gln Trp Tyr Gln Asn Ser Cys Tyr Tyr Phe Thr Thr Asn 
145                 150                 155                 160 


Glu Glu Lys Thr Trp Ala Asn Ser Arg Lys Asp Cys Ile Asp Lys Asn 
                165                 170                 175     


Ser Thr Leu Val Lys Ile Asp Ser Leu Glu Glu Lys Asp Phe Leu Met 
            180                 185                 190         


Ser Gln Pro Leu Leu Met Phe Ser Phe Phe Trp Leu Gly Leu Ser Trp 
        195                 200                 205             


Asp Ser Ser Gly Arg Ser Trp Phe Trp Glu Asp Gly Ser Val Pro Ser 
    210                 215                 220                 


Pro Ser Leu Phe Ser Thr Lys Glu Leu Asp Gln Ile Asn Gly Ser Lys 
225                 230                 235                 240 


Gly Cys Ala Tyr Phe Gln Lys Gly Asn Ile Tyr Ile Ser Arg Cys Ser 
                245                 250                 255     


Ala Glu Ile Phe Trp Ile Cys Glu Lys Thr Ala Ala Pro Val Lys Thr 
            260                 265                 270         


Glu Asp Leu Asp 
        275     


<210>  1408
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  1408

Met Asp Pro Val Ser Gln Leu Ala Ser Ala Gly Thr Phe Arg Val Leu 
1               5                   10                  15      


Lys Glu Pro Leu Ala Phe Leu Arg Ala Leu Glu Leu Leu Phe Ala Ile 
            20                  25                  30          


Phe Ala Phe Ala Thr Cys Gly Gly Tyr Ser Gly Gly Leu Arg Leu Ser 
        35                  40                  45              


Val Asp Cys Val Asn Lys Thr Glu Ser Asn Leu Ser Ile Asp Ile Ala 
    50                  55                  60                  


Phe Ala Tyr Pro Phe Arg Leu His Gln Val Thr Phe Glu Val Pro Thr 
65                  70                  75                  80  


Cys Glu Gly Lys Glu Arg Gln Lys Leu Ala Leu Ile Gly Asp Ser Ser 
                85                  90                  95      


Ser Ser Ala Glu Phe Phe Val Thr Val Ala Val Phe Ala Phe Leu Tyr 
            100                 105                 110         


Ser Leu Ala Ala Thr Val Val Tyr Ile Phe Phe Gln Asn Lys Tyr Arg 
        115                 120                 125             


Glu Asn Asn Arg Gly Pro Leu Ile Asp Phe Ile Val Thr Val Val Phe 
    130                 135                 140                 


Ser Phe Leu Trp Leu Val Gly Ser Ser Ala Trp Ala Lys Gly Leu Ser 
145                 150                 155                 160 


Asp Val Lys Val Ala Thr Asp Pro Lys Glu Val Leu Leu Leu Met Ser 
                165                 170                 175     


Ala Cys Lys Gln Pro Ser Asn Lys Cys Met Ala Ile His Ser Pro Val 
            180                 185                 190         


Met Ser Ser Leu Asn Thr Ser Val Val Phe Gly Phe Leu Asn Phe Ile 
        195                 200                 205             


Leu Trp Ala Gly Asn Ile Trp Phe Val Phe Lys Glu Thr Gly Trp His 
    210                 215                 220                 


Ser Ser Gly Gln Arg Tyr Leu Ser Asp Pro Met Glu Lys His Ser Ser 
225                 230                 235                 240 


Ser Tyr Asn Gln Gly Gly Tyr Asn Gln Asp Ser Tyr Gly Ser Ser Ser 
                245                 250                 255     


Gly Tyr Ser Gln Gln Ala Ser Leu Gly Pro Thr Ser Asp Glu Phe Gly 
            260                 265                 270         


Gln Gln Pro Thr Gly Pro Thr Ser Phe Thr Asn Gln Ile 
        275                 280                 285 


<210>  1409
<211>  389
<212>  PRT
<213>  Homo sapiens

<400>  1409

Met Lys Thr Gly His Phe Glu Ile Val Thr Met Leu Leu Ala Thr Met 
1               5                   10                  15      


Ile Leu Val Asp Ile Phe Gln Val Lys Ala Glu Val Leu Asp Met Ala 
            20                  25                  30          


Asp Asn Ala Phe Asp Asp Glu Tyr Leu Lys Cys Thr Asp Arg Met Glu 
        35                  40                  45              


Ile Lys Tyr Val Pro Gln Leu Leu Lys Glu Glu Lys Ala Ser His Gln 
    50                  55                  60                  


Gln Leu Asp Thr Val Trp Glu Asn Ala Lys Ala Lys Trp Ala Ala Arg 
65                  70                  75                  80  


Lys Thr Gln Ile Phe Leu Pro Met Asn Phe Lys Asp Asn His Gly Ile 
                85                  90                  95      


Ala Leu Met Ala Tyr Ile Ser Glu Ala Gln Glu Gln Thr Pro Phe Tyr 
            100                 105                 110         


His Leu Phe Ser Glu Ala Val Lys Met Ala Gly Gln Ser Arg Glu Asp 
        115                 120                 125             


Tyr Ile Tyr Gly Phe Gln Phe Lys Ala Phe His Phe Tyr Leu Thr Arg 
    130                 135                 140                 


Ala Leu Gln Leu Leu Arg Lys Pro Cys Glu Ala Ser Ser Lys Thr Val 
145                 150                 155                 160 


Val Tyr Arg Thr Ser Gln Gly Thr Ser Phe Thr Phe Gly Gly Leu Asn 
                165                 170                 175     


Gln Ala Arg Phe Gly His Phe Thr Leu Ala Tyr Ser Ala Lys Pro Gln 
            180                 185                 190         


Ala Ala Asn Asp Gln Leu Thr Val Leu Ser Ile Tyr Thr Cys Leu Gly 
        195                 200                 205             


Val Asp Ile Glu Asn Phe Leu Asp Lys Glu Ser Glu Arg Ile Thr Leu 
    210                 215                 220                 


Ile Pro Leu Asn Glu Val Phe Gln Val Ser Gln Glu Gly Ala Gly Asn 
225                 230                 235                 240 


Asn Leu Ile Leu Gln Ser Ile Asn Lys Thr Cys Ser His Tyr Glu Cys 
                245                 250                 255     


Ala Phe Leu Gly Gly Leu Lys Thr Glu Asn Cys Ile Glu Asn Leu Glu 
            260                 265                 270         


Tyr Phe Gln Pro Ile Tyr Val Tyr Asn Pro Gly Glu Lys Asn Gln Lys 
        275                 280                 285             


Leu Glu Asp His Ser Glu Lys Asn Trp Lys Leu Glu Asp His Gly Glu 
    290                 295                 300                 


Lys Asn Gln Lys Leu Glu Asp His Gly Val Lys Ile Leu Glu Pro Thr 
305                 310                 315                 320 


Gln Ile Pro Gly Met Lys Ile Pro Glu Pro Phe Pro Leu Pro Glu Asp 
                325                 330                 335     


Lys Ser Gln Gly Asn Ile Asn Asn Pro Thr Pro Gly Pro Val Pro Val 
            340                 345                 350         


Pro Gly Pro Lys Ser His Pro Ser Ala Ser Ser Gly Lys Leu Leu Leu 
        355                 360                 365             


Pro Gln Phe Gly Met Val Ile Ile Leu Ile Ser Val Ser Ala Ile Asn 
    370                 375                 380                 


Leu Phe Val Ala Leu 
385                 


<210>  1410
<211>  367
<212>  PRT
<213>  Homo sapiens

<400>  1410

Met Lys Thr Gly His Phe Glu Ile Val Thr Met Leu Leu Ala Thr Met 
1               5                   10                  15      


Ile Leu Val Asp Ile Phe Gln Val Lys Ala Glu Val Leu Asp Met Ala 
            20                  25                  30          


Asp Asn Ala Phe Asp Asp Glu Tyr Leu Lys Cys Thr Asp Arg Met Glu 
        35                  40                  45              


Ile Lys Tyr Val Pro Gln Leu Leu Lys Glu Glu Lys Ala Ser His Gln 
    50                  55                  60                  


Gln Leu Asp Thr Val Trp Glu Asn Ala Lys Ala Lys Trp Ala Ala Arg 
65                  70                  75                  80  


Lys Thr Gln Ile Phe Leu Pro Met Asn Phe Lys Asp Asn His Gly Ile 
                85                  90                  95      


Ala Leu Met Ala Tyr Ile Ser Glu Ala Gln Glu Gln Thr Pro Phe Tyr 
            100                 105                 110         


His Leu Phe Ser Glu Ala Val Lys Met Ala Gly Gln Ser Arg Glu Asp 
        115                 120                 125             


Tyr Ile Tyr Gly Phe Gln Phe Lys Ala Phe His Phe Tyr Leu Thr Arg 
    130                 135                 140                 


Ala Leu Gln Leu Leu Arg Lys Pro Cys Glu Ala Ser Ser Lys Thr Val 
145                 150                 155                 160 


Val Tyr Arg Thr Ser Gln Gly Thr Ser Phe Thr Phe Gly Gly Leu Asn 
                165                 170                 175     


Gln Ala Arg Phe Gly His Phe Thr Leu Ala Tyr Ser Ala Lys Pro Gln 
            180                 185                 190         


Ala Ala Asn Asp Gln Leu Thr Val Leu Ser Ile Tyr Thr Cys Leu Gly 
        195                 200                 205             


Val Asp Ile Glu Asn Phe Leu Asp Lys Glu Ser Glu Arg Ile Thr Leu 
    210                 215                 220                 


Ile Pro Leu Asn Glu Val Phe Gln Val Ser Gln Glu Gly Ala Gly Asn 
225                 230                 235                 240 


Asn Leu Ile Leu Gln Ser Ile Asn Lys Thr Cys Ser His Tyr Glu Cys 
                245                 250                 255     


Ala Phe Leu Gly Gly Leu Lys Thr Glu Asn Cys Ile Glu Asn Leu Glu 
            260                 265                 270         


Tyr Phe Gln Pro Ile Tyr Val Tyr Asn Pro Gly Glu Lys Asn Gln Lys 
        275                 280                 285             


Leu Glu Asp His Ser Glu Lys Asn Trp Lys Leu Glu Asp His Gly Glu 
    290                 295                 300                 


Lys Asn Gln Lys Leu Glu Asp His Gly Val Lys Ile Leu Glu Pro Thr 
305                 310                 315                 320 


Gln Ile Pro Ala Pro Gly Pro Val Pro Val Pro Gly Pro Lys Ser His 
                325                 330                 335     


Pro Ser Ala Ser Ser Gly Lys Leu Leu Leu Pro Gln Phe Gly Met Val 
            340                 345                 350         


Ile Ile Leu Ile Ser Val Ser Ala Ile Asn Leu Phe Val Ala Leu 
        355                 360                 365         


<210>  1411
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  1411

Met Ser Glu Pro Gln Pro Asp Leu Glu Pro Pro Gln His Gly Leu Tyr 
1               5                   10                  15      


Met Leu Phe Leu Leu Val Leu Val Phe Phe Leu Met Gly Leu Val Gly 
            20                  25                  30          


Phe Met Ile Cys His Val Leu Lys Lys Lys Gly Tyr Arg Cys Arg Thr 
        35                  40                  45              


Ser Arg Gly Ser Glu Pro Asp Asp Ala Gln Leu Gln Pro Pro Glu Asp 
    50                  55                  60                  


Asp Asp Met Asn Glu Asp Thr Val Glu Arg Ile Val Arg Cys Ile Ile 
65                  70                  75                  80  


Gln Asn Glu Ala Asn Ala Glu Ala Leu Lys Glu Met Leu Gly Asp Ser 
                85                  90                  95      


Glu Gly Glu Gly Thr Val Gln Leu Ser Ser Val Asp Ala Thr Ser Ser 
            100                 105                 110         


Leu Gln Asp Gly Ala Pro Ser His His His Thr Val His Leu Gly Ser 
        115                 120                 125             


Ala Ala Pro Cys Leu His Cys Ser Arg Ser Lys Arg Pro Pro Leu Val 
    130                 135                 140                 


Arg Gln Gly Arg Ser Lys Glu Gly Lys Ser Arg Pro Arg Thr Gly Glu 
145                 150                 155                 160 


Thr Thr Val Phe Ser Val Gly Arg Phe Arg Val Thr His Ile Glu Lys 
                165                 170                 175     


Arg Tyr Gly Leu His Glu His Arg Asp Gly Ser Pro Thr Asp Arg Ser 
            180                 185                 190         


Trp Gly Ser Gly Gly Gly Gln Asp Pro Gly Gly Gly Gln Gly Ser Gly 
        195                 200                 205             


Gly Gly Gln Pro Lys Ala Gly Met Pro Ala Met Glu Arg Leu Pro Pro 
    210                 215                 220                 


Glu Arg Pro Gln Pro Gln Val Leu Ala Ser Pro Pro Val Gln Asn Gly 
225                 230                 235                 240 


Gly Leu Arg Asp Ser Ser Leu Thr Pro Arg Ala Leu Glu Gly Asn Pro 
                245                 250                 255     


Arg Ala Ser Ala Glu Pro Thr Leu Arg Ala Gly Gly Arg Gly Pro Ser 
            260                 265                 270         


Pro Gly Leu Pro Thr Gln Glu Ala Asn Gly Gln Pro Ser Lys Pro Asp 
        275                 280                 285             


Thr Ser Asp His Gln Val Ser Leu Pro Gln Gly Ala Gly Ser Met 
    290                 295                 300             


<210>  1412
<211>  717
<212>  PRT
<213>  Homo sapiens

<400>  1412

Met Asn Asp Thr Glu Lys Pro Ala Asp Thr Pro Ser Glu Glu Glu Asp 
1               5                   10                  15      


Phe Gly Asp Pro Arg Thr Tyr Asp Pro Asp Phe Lys Gly Pro Val Ala 
            20                  25                  30          


Asn Arg Ser Cys Thr Asp Val Leu Cys Cys Met Ile Phe Leu Leu Cys 
        35                  40                  45              


Ile Ile Gly Tyr Ile Val Leu Gly Leu Val Ala Trp Val His Gly Asp 
    50                  55                  60                  


Pro Arg Arg Ala Ala Tyr Pro Thr Asp Ser Gln Gly His Phe Cys Gly 
65                  70                  75                  80  


Gln Lys Gly Thr Pro Asn Glu Asn Lys Thr Ile Leu Phe Tyr Phe Asn 
                85                  90                  95      


Leu Leu Arg Cys Thr Ser Pro Ser Val Leu Leu Asn Leu Gln Cys Pro 
            100                 105                 110         


Thr Thr Gln Ile Cys Val Ser Lys Cys Pro Glu Lys Phe Leu Thr Tyr 
        115                 120                 125             


Val Glu Met Gln Leu Leu Tyr Thr Lys Asp Lys Ser Tyr Trp Glu Asp 
    130                 135                 140                 


Tyr Arg Gln Phe Cys Lys Thr Thr Ala Lys Pro Val Lys Ser Leu Thr 
145                 150                 155                 160 


Gln Leu Leu Leu Asp Asp Asp Cys Pro Thr Ala Ile Phe Pro Ser Lys 
                165                 170                 175     


Pro Phe Leu Gln Arg Cys Phe Pro Asp Phe Ser Thr Lys Asn Gly Thr 
            180                 185                 190         


Leu Thr Ile Gly Ser Lys Met Met Phe Gln Asp Gly Asn Gly Gly Thr 
        195                 200                 205             


Arg Ser Val Val Glu Leu Gly Ile Ala Ala Asn Gly Ile Asn Lys Leu 
    210                 215                 220                 


Leu Asp Ala Lys Ser Leu Gly Leu Lys Val Phe Glu Asp Tyr Ala Arg 
225                 230                 235                 240 


Thr Trp Tyr Trp Ile Leu Ile Gly Leu Thr Ile Ala Met Val Leu Ser 
                245                 250                 255     


Trp Ile Phe Leu Ile Leu Leu Arg Phe Ile Ala Gly Cys Leu Phe Trp 
            260                 265                 270         


Val Phe Met Ile Gly Val Ile Gly Ile Ile Gly Tyr Gly Ile Trp His 
        275                 280                 285             


Cys Tyr Gln Gln Tyr Thr Asn Leu Gln Glu Arg Pro Ser Ser Val Leu 
    290                 295                 300                 


Thr Ile Tyr Asp Ile Gly Ile Gln Thr Asn Ile Ser Met Tyr Phe Glu 
305                 310                 315                 320 


Leu Gln Gln Thr Trp Phe Thr Phe Met Ile Ile Leu Cys Ile Ile Glu 
                325                 330                 335     


Val Ile Val Ile Leu Met Leu Ile Phe Leu Arg Asn Arg Ile Arg Val 
            340                 345                 350         


Ala Ile Ile Leu Leu Lys Glu Gly Ser Lys Ala Ile Gly Tyr Val Pro 
        355                 360                 365             


Ser Thr Leu Val Tyr Pro Ala Leu Thr Phe Ile Leu Leu Ser Ile Cys 
    370                 375                 380                 


Ile Cys Tyr Trp Val Val Thr Ala Val Phe Leu Ala Thr Ser Gly Val 
385                 390                 395                 400 


Pro Val Tyr Lys Val Ile Ala Pro Gly Gly His Cys Ile His Glu Asn 
                405                 410                 415     


Gln Thr Cys Asp Pro Glu Ile Phe Asn Thr Thr Glu Ile Ala Lys Ala 
            420                 425                 430         


Cys Pro Gly Ala Leu Cys Asn Phe Ala Phe Tyr Gly Gly Lys Ser Leu 
        435                 440                 445             


Tyr His Gln Tyr Ile Pro Thr Phe His Val Tyr Asn Leu Phe Val Phe 
    450                 455                 460                 


Leu Trp Leu Ile Asn Phe Val Ile Ala Leu Gly Gln Cys Ala Leu Ala 
465                 470                 475                 480 


Gly Ala Phe Ala Thr Tyr Tyr Trp Ala Met Lys Lys Pro Asp Asp Ile 
                485                 490                 495     


Pro Arg Tyr Pro Leu Phe Thr Ala Phe Gly Arg Ala Ile Arg Tyr His 
            500                 505                 510         


Thr Gly Ser Leu Ala Phe Gly Ser Leu Ile Ile Ala Leu Ile Gln Met 
        515                 520                 525             


Phe Lys Ile Val Leu Glu Tyr Leu Asp His Arg Leu Lys Arg Thr Gln 
    530                 535                 540                 


Asn Thr Leu Ser Lys Phe Leu Gln Cys Cys Leu Arg Cys Cys Phe Trp 
545                 550                 555                 560 


Cys Leu Glu Asn Ala Ile Lys Phe Leu Asn Arg Asn Ala Tyr Ile Met 
                565                 570                 575     


Ile Ala Ile Tyr Gly Arg Asn Phe Cys Arg Ser Ala Lys Asp Ala Phe 
            580                 585                 590         


Asn Leu Leu Met Arg Asn Val Leu Lys Val Ala Val Thr Asp Glu Val 
        595                 600                 605             


Thr Tyr Phe Val Leu Phe Leu Gly Lys Leu Leu Val Ala Gly Ser Ile 
    610                 615                 620                 


Gly Val Leu Ala Phe Leu Phe Phe Thr Gln Arg Leu Pro Val Ile Ala 
625                 630                 635                 640 


Gln Gly Pro Ala Ser Leu Asn Tyr Tyr Trp Val Pro Leu Leu Thr Val 
                645                 650                 655     


Ile Phe Gly Ser Tyr Leu Ile Ala His Gly Phe Phe Ser Val Tyr Ala 
            660                 665                 670         


Met Cys Val Glu Thr Ile Phe Ile Cys Phe Leu Glu Asp Leu Glu Arg 
        675                 680                 685             


Asn Asp Gly Ser Thr Ala Arg Pro Tyr Tyr Val Ser Gln Pro Leu Leu 
    690                 695                 700                 


Lys Ile Phe Gln Glu Glu Asn Pro Gln Thr Arg Lys Gln 
705                 710                 715         


<210>  1413
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  1413

Met Gly Asp Asp Arg Pro Phe Val Cys Asn Ala Pro Gly Cys Gly Gln 
1               5                   10                  15      


Arg Phe Thr Asn Glu Asp His Leu Ala Val His Lys His Lys His Glu 
            20                  25                  30          


Met Thr Leu Lys Phe Gly Pro Ala Arg Thr Asp Ser Val Ile Ile Ala 
        35                  40                  45              


Asp Gln Thr Pro Thr Pro Thr Arg Phe Leu Lys Asn Cys Glu Glu Val 
    50                  55                  60                  


Gly Leu Phe Asn Glu Leu Ala Ser Ser Phe Glu His Glu Phe Lys Lys 
65                  70                  75                  80  


Ala Ala Asp Glu Asp Glu Lys Lys Ala Ala Ala Gly Pro Leu Asp Met 
                85                  90                  95      


Ser Leu Pro Ser Thr Pro Asp Ile Lys Ile Lys Glu Glu Glu Pro Val 
            100                 105                 110         


Glu Glu Val Thr Pro Lys Pro Val Leu Ile Ser Thr Pro Thr Pro Thr 
        115                 120                 125             


Ile Val Arg Pro Gly Ser Leu Pro Leu His Leu Gly Tyr Asp Pro Leu 
    130                 135                 140                 


His Pro Thr Leu Pro Ser Pro Thr Ser Val Ile Thr Gln Ala Pro Pro 
145                 150                 155                 160 


Ser Asn Arg Gln Met Gly Ser Pro Thr Gly Ser Leu Pro Leu Val Met 
                165                 170                 175     


His Leu Ala Asn Gly Gln Thr Met Pro Val Leu Pro Gly Pro Pro Val 
            180                 185                 190         


Gln Met Pro Ser Val Ile Ser Leu Ala Arg Pro Val Ser Met Val Pro 
        195                 200                 205             


Asn Ile Pro Gly Ile Pro Gly Pro Pro Val Asn Ser Ser Gly Ser Ile 
    210                 215                 220                 


Ser Pro Ser Gly His Pro Ile Pro Ser Glu Ala Lys Met Arg Leu Lys 
225                 230                 235                 240 


Ala Thr Leu Thr His Gln Val Ser Ser Ile Asn Gly Gly Cys Gly Met 
                245                 250                 255     


Val Val Gly Thr Ala Ser Thr Met Val Thr Ala Arg Pro Glu Gln Ser 
            260                 265                 270         


Gln Ile Leu Ile Gln His Pro Asp Ala Pro Ser Pro Ala Gln Pro Gln 
        275                 280                 285             


Val Ser Pro Ala Gln Pro Thr Pro Ser Thr Gly Gly Arg Arg Arg Arg 
    290                 295                 300                 


Thr Val Asp Glu Asp Pro Asp Glu Arg Arg Gln Arg Phe Leu Glu Arg 
305                 310                 315                 320 


Asn Arg Ala Ala Ala Ser Arg Cys Arg Gln Lys Arg Lys Leu Trp Val 
                325                 330                 335     


Ser Ser Leu Glu Lys Lys Ala Glu Glu Leu Thr Ser Gln Asn Ile Gln 
            340                 345                 350         


Leu Ser Asn Glu Val Thr Leu Leu Arg Asn Glu Val Ala Gln Leu Lys 
        355                 360                 365             


Gln Leu Leu Leu Ala His Lys Asp Cys Pro Val Thr Ala Leu Gln Lys 
    370                 375                 380                 


Lys Thr Gln Gly Tyr Leu Glu Ser Pro Lys Glu Ser Ser Glu Pro Thr 
385                 390                 395                 400 


Gly Ser Pro Ala Pro Val Ile Gln His Ser Ser Ala Thr Ala Pro Ser 
                405                 410                 415     


Asn Gly Leu Ser Val Arg Ser Ala Ala Glu Ala Val Ala Thr Ser Val 
            420                 425                 430         


Leu Thr Gln Met Ala Ser Gln Arg Thr Glu Leu Ser Met Pro Ile Gln 
        435                 440                 445             


Ser His Val Ile Met Thr Pro Gln Ser Gln Ser Ala Gly Arg Ala 
    450                 455                 460             


<210>  1414
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  1414

Met Gly Asp Asp Arg Pro Phe Val Cys Asn Ala Pro Gly Cys Gly Gln 
1               5                   10                  15      


Arg Phe Thr Asn Glu Asp His Leu Ala Val His Lys His Lys His Glu 
            20                  25                  30          


Met Thr Leu Lys Phe Gly Pro Ala Arg Thr Asp Ser Val Ile Ile Ala 
        35                  40                  45              


Asp Gln Thr Pro Thr Pro Thr Arg Phe Leu Lys Asn Cys Glu Glu Val 
    50                  55                  60                  


Gly Leu Phe Asn Glu Leu Ala Ser Ser Phe Glu His Glu Phe Lys Lys 
65                  70                  75                  80  


Ala Ala Asp Glu Asp Glu Lys Lys Ala Ala Ala Gly Pro Leu Asp Met 
                85                  90                  95      


Ser Leu Pro Ser Thr Pro Asp Ile Lys Ile Lys Glu Glu Glu Pro Val 
            100                 105                 110         


Glu Glu Val Thr Pro Lys Pro Val Leu Ile Ser Thr Pro Thr Pro Thr 
        115                 120                 125             


Ile Val Arg Pro Gly Ser Leu Pro Leu His Leu Gly Tyr Asp Pro Leu 
    130                 135                 140                 


His Pro Thr Leu Pro Ser Pro Thr Ser Val Ile Thr Gln Ala Pro Pro 
145                 150                 155                 160 


Ser Asn Arg Gln Met Gly Ser Pro Thr Gly Ser Leu Pro Leu Val Met 
                165                 170                 175     


His Leu Ala Asn Gly Gln Thr Met Pro Val Leu Pro Gly Pro Pro Val 
            180                 185                 190         


Gln Met Pro Ser Val Ile Ser Leu Ala Arg Pro Val Ser Met Val Pro 
        195                 200                 205             


Asn Ile Pro Gly Ile Pro Gly Pro Pro Val Asn Ser Ser Gly Ser Ile 
    210                 215                 220                 


Ser Pro Ser Gly His Pro Ile Pro Ser Glu Ala Lys Met Arg Leu Lys 
225                 230                 235                 240 


Ala Thr Leu Thr His Gln Val Ser Ser Ile Asn Gly Gly Cys Gly Met 
                245                 250                 255     


Val Val Gly Thr Ala Ser Thr Met Val Thr Ala Arg Pro Glu Gln Ser 
            260                 265                 270         


Gln Ile Leu Ile Gln His Pro Asp Ala Pro Ser Pro Ala Gln Pro Gln 
        275                 280                 285             


Val Ser Pro Ala Gln Pro Thr Pro Ser Thr Gly Gly Arg Arg Arg Arg 
    290                 295                 300                 


Thr Val Asp Glu Asp Pro Asp Glu Arg Arg Gln Arg Phe Leu Glu Arg 
305                 310                 315                 320 


Asn Arg Ala Ala Ala Ser Arg Cys Arg Gln Lys Arg Lys Leu Trp Val 
                325                 330                 335     


Ser Ser Leu Glu Lys Lys Ala Glu Glu Leu Thr Ser Gln Asn Ile Gln 
            340                 345                 350         


Leu Ser Asn Glu Val Thr Leu Leu Arg Asn Glu Val Ala Gln Leu Lys 
        355                 360                 365             


Gln Leu Leu Leu Ala His Lys Asp Cys Pro Val Thr Ala Leu Gln Lys 
    370                 375                 380                 


Lys Thr Gln Gly Tyr Leu Glu Ser Pro Lys Glu Ser Ser Glu Pro Thr 
385                 390                 395                 400 


Gly Ser Pro Ala Pro Val Ile Gln His Ser Ser Ala Thr Ala Pro Ser 
                405                 410                 415     


Asn Gly Leu Ser Val Arg Ser Ala Ala Glu Ala Val Ala Thr Ser Val 
            420                 425                 430         


Leu Thr Gln Met Ala Ser Gln Arg Thr Glu Leu Ser Met Pro Ile Gln 
        435                 440                 445             


Ser His Val Ile Met Thr Pro Gln Ser Gln Ser Ala Gly Arg 
    450                 455                 460         


<210>  1415
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  1415

Met Thr Phe Ile Phe Ile Ala Lys Pro Ser Thr Ala Val Cys Thr Leu 
1               5                   10                  15      


Arg Arg Leu Gly Leu Gly Thr Ala Phe Ser Val Cys Tyr Ser Ala Leu 
            20                  25                  30          


Leu Thr Lys Thr Asn Arg Ile Ala Arg Ile Phe Gly Gly Ala Arg Glu 
        35                  40                  45              


Gly Ala Gln Arg Pro Arg Phe Ile Ser Pro Ala Ser Gln Val Ala Ile 
    50                  55                  60                  


Cys Leu Ala Leu Ile Ser Gly Gln Leu Leu Ile Val Val Ala Trp Leu 
65                  70                  75                  80  


Val Val Glu Ala Pro Gly Thr Gly Lys Glu Thr Ala Pro Glu Arg Arg 
                85                  90                  95      


Glu Val Val Thr Leu Arg Cys Asn His Arg Asp Ala Ser Met Leu Gly 
            100                 105                 110         


Ser Leu Ala Tyr Asn Val Leu Leu Ile Ala Leu Cys Thr Leu Tyr Ala 
        115                 120                 125             


Phe Lys Thr Arg Lys Cys Pro Glu Asn Phe Asn Glu Ala Lys Phe Ile 
    130                 135                 140                 


Gly Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala Phe Leu Pro 
145                 150                 155                 160 


Ile Phe Tyr Val Thr Ser Ser Asp Tyr Arg Val Gln Thr Thr Thr Met 
                165                 170                 175     


Cys Val Ser Val Ser Leu Ser Gly Ser Val Val Leu Gly Cys Leu Phe 
            180                 185                 190         


Ala Pro Lys Leu His Ile Ile Leu Phe Gln Pro Gln Lys Asn Val Val 
        195                 200                 205             


Ser His Arg Ala Pro Thr Ser Arg Phe Gly Ser Ala Ala Ala Arg Ala 
    210                 215                 220                 


Ser Ser Ser Leu Gly Gln Gly Ser Gly Ser Gln Phe Val Pro Thr Val 
225                 230                 235                 240 


Cys Asn Gly Arg Glu Val Val Asp Ser Thr Thr Ser Ser Leu 
                245                 250                 


<210>  1416
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  1416

Met Arg Ala His Ala Gln Arg Gly Arg Gly Cys Thr Arg Arg Ser Ala 
1               5                   10                  15      


Ala Val Leu Met Ala Arg His Gly Leu Pro Leu Leu Pro Leu Leu Ser 
            20                  25                  30          


Leu Leu Val Gly Ala Trp Leu Lys Leu Gly Asn Gly Gln Ala Thr Ser 
        35                  40                  45              


Met Val Gln Leu Gln Gly Gly Arg Phe Leu Met Gly Thr Asn Ser Pro 
    50                  55                  60                  


Asp Ser Arg Asp Gly Glu Gly Pro Val Arg Glu Ala Thr Val Lys Pro 
65                  70                  75                  80  


Phe Ala Ile Asp Ile Phe Pro Val Thr Asn Lys Asp Phe Arg Asp Phe 
                85                  90                  95      


Val Arg Glu Lys Lys Tyr Arg Thr Glu Ala Glu Met Phe Gly Trp Ser 
            100                 105                 110         


Phe Val Phe Glu Asp Phe Val Ser Asp Glu Leu Arg Asn Lys Ala Thr 
        115                 120                 125             


Gln Pro Met Lys Ser Val Leu Trp Trp Leu Pro Val Glu Lys Ala Phe 
    130                 135                 140                 


Trp Arg Gln Pro Ala Gly Pro Gly Ser Gly Ile Arg Glu Arg Leu Glu 
145                 150                 155                 160 


His Pro Val Leu His Val Ser Trp Asn Asp Ala Arg Ala Tyr Cys Ala 
                165                 170                 175     


Trp Arg Gly Lys Arg Leu Pro Thr Glu Glu Glu Trp Glu Phe Ala Ala 
            180                 185                 190         


Arg Gly Gly Leu Lys Gly Gln Val Tyr Pro Trp Gly Asn Trp Phe Gln 
        195                 200                 205             


Pro Asn Arg Thr Asn Leu Trp Gln Gly Lys Phe Pro Lys Gly Asp Lys 
    210                 215                 220                 


Ala Glu Asp Gly Phe His Gly Val Ser Pro Val Asn Ala Phe Pro Ala 
225                 230                 235                 240 


Gln Asn Asn Tyr Gly Trp Ala Thr Leu Gln Ile Gln Pro Gln Thr Thr 
                245                 250                 255     


Ser Val Ser Ala Val Leu Gln Thr Gln Ala Gly Arg Gln Gly Ser Cys 
            260                 265                 270         


Lys Gln Pro Gly Gly Asp Lys Glu Lys Ser Leu Leu Gly Ser Leu Ser 
        275                 280                 285             


Phe Pro Gly His Val Ala Asn Ser Ala Ile Pro Ser Ser Arg Ala Ser 
    290                 295                 300                 


Ala Ser Gly Lys Asn Phe Pro Phe Pro Val Ser His Pro Ser Val Ala 
305                 310                 315                 320 


Gly Ala Ser His Gln Gly Arg Arg Gly Leu Ser Leu Leu Cys Phe Gly 
                325                 330                 335     


Glu Gly Ala Gln Cys Val Leu Thr Met Ala Gly Gly Gln Val Phe Leu 
            340                 345                 350         


Leu Glu Ala Lys Tyr Tyr 
        355             


<210>  1417
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  1417

Met Glu Ala Ser Ala Leu Thr Ser Ser Ala Val Thr Ser Val Ala Lys 
1               5                   10                  15      


Val Val Arg Val Ala Ser Gly Ser Ala Val Val Leu Pro Leu Ala Arg 
            20                  25                  30          


Ile Ala Thr Val Val Ile Gly Gly Val Val Ala Met Ala Ala Val Pro 
        35                  40                  45              


Met Val Leu Ser Ala Met Gly Phe Thr Ala Ala Gly Ile Ala Ser Ser 
    50                  55                  60                  


Ser Ile Ala Ala Lys Met Met Ser Ala Ala Ala Ile Ala Asn Gly Gly 
65                  70                  75                  80  


Gly Val Ala Ser Gly Ser Leu Val Ala Thr Leu Gln Ser Leu Gly Ala 
                85                  90                  95      


Thr Gly Leu Ser Gly Leu Thr Lys Phe Ile Leu Gly Ser Ile Gly Ser 
            100                 105                 110         


Ala Ile Ala Ala Val Ile Ala Arg Phe Tyr 
        115                 120         


<210>  1418
<211>  745
<212>  PRT
<213>  Homo sapiens

<400>  1418

Met Phe Pro Leu Arg Ala Leu Trp Leu Val Trp Ala Leu Leu Gly Val 
1               5                   10                  15      


Ala Gly Ser Cys Pro Glu Pro Cys Ala Cys Val Asp Lys Tyr Ala His 
            20                  25                  30          


Gln Phe Ala Asp Cys Ala Tyr Lys Glu Leu Arg Glu Val Pro Glu Gly 
        35                  40                  45              


Leu Pro Ala Asn Val Thr Thr Leu Ser Leu Ser Ala Asn Lys Ile Thr 
    50                  55                  60                  


Val Leu Arg Arg Gly Ala Phe Ala Asp Val Thr Gln Val Thr Ser Leu 
65                  70                  75                  80  


Trp Leu Ala His Asn Glu Val Arg Thr Val Glu Pro Gly Ala Leu Ala 
                85                  90                  95      


Val Leu Ser Gln Leu Lys Asn Leu Asp Leu Ser His Asn Phe Ile Ser 
            100                 105                 110         


Ser Phe Pro Trp Ser Asp Leu Arg Asn Leu Ser Ala Leu Gln Leu Leu 
        115                 120                 125             


Lys Met Asn His Asn Arg Leu Gly Ser Leu Pro Arg Asp Ala Leu Gly 
    130                 135                 140                 


Ala Leu Pro Asp Leu Arg Ser Leu Arg Ile Asn Asn Asn Arg Leu Arg 
145                 150                 155                 160 


Thr Leu Ala Pro Gly Thr Phe Asp Ala Leu Ser Ala Leu Ser His Leu 
                165                 170                 175     


Gln Leu Tyr His Asn Pro Phe His Cys Gly Cys Gly Leu Val Trp Leu 
            180                 185                 190         


Gln Ala Trp Ala Ala Ser Thr Arg Val Ser Leu Pro Glu Pro Asp Ser 
        195                 200                 205             


Ile Ala Cys Ala Ser Pro Pro Ala Leu Gln Gly Val Pro Val Tyr Arg 
    210                 215                 220                 


Leu Pro Ala Leu Pro Cys Ala Pro Pro Ser Val His Leu Ser Ala Glu 
225                 230                 235                 240 


Pro Pro Leu Glu Ala Pro Gly Thr Pro Leu Arg Ala Gly Leu Ala Phe 
                245                 250                 255     


Val Leu His Cys Ile Ala Asp Gly His Pro Thr Pro Arg Leu Gln Trp 
            260                 265                 270         


Gln Leu Gln Ile Pro Gly Gly Thr Val Val Leu Glu Pro Pro Val Leu 
        275                 280                 285             


Ser Gly Glu Asp Asp Gly Val Gly Ala Glu Glu Gly Glu Gly Glu Gly 
    290                 295                 300                 


Asp Gly Asp Leu Leu Thr Gln Thr Gln Ala Gln Thr Pro Thr Pro Ala 
305                 310                 315                 320 


Pro Ala Trp Pro Ala Pro Pro Ala Thr Pro Arg Phe Leu Ala Leu Ala 
                325                 330                 335     


Asn Gly Ser Leu Leu Val Pro Leu Leu Ser Ala Lys Glu Ala Gly Val 
            340                 345                 350         


Tyr Thr Cys Arg Ala His Asn Glu Leu Gly Ala Asn Ser Thr Ser Ile 
        355                 360                 365             


Arg Val Ala Val Ala Ala Thr Gly Pro Pro Lys His Ala Pro Gly Ala 
    370                 375                 380                 


Gly Gly Glu Pro Asp Gly Gln Ala Pro Thr Ser Glu Arg Lys Ser Thr 
385                 390                 395                 400 


Ala Lys Gly Arg Gly Asn Ser Val Leu Pro Ser Lys Pro Glu Gly Lys 
                405                 410                 415     


Ile Lys Gly Gln Gly Leu Ala Lys Val Ser Ile Leu Gly Glu Thr Glu 
            420                 425                 430         


Thr Glu Pro Glu Glu Asp Thr Ser Glu Gly Glu Glu Ala Glu Asp Gln 
        435                 440                 445             


Ile Leu Ala Asp Pro Ala Glu Glu Gln Arg Cys Gly Asn Gly Asp Pro 
    450                 455                 460                 


Ser Arg Tyr Val Ser Asn His Ala Phe Asn Gln Ser Ala Glu Leu Lys 
465                 470                 475                 480 


Pro His Val Phe Glu Leu Gly Val Ile Ala Leu Asp Val Ala Glu Arg 
                485                 490                 495     


Glu Ala Arg Val Gln Leu Thr Pro Leu Ala Ala Arg Trp Gly Pro Gly 
            500                 505                 510         


Pro Gly Gly Ala Gly Gly Ala Pro Arg Pro Gly Arg Arg Pro Leu Arg 
        515                 520                 525             


Leu Leu Tyr Leu Cys Pro Ala Gly Gly Gly Ala Ala Val Gln Trp Ser 
    530                 535                 540                 


Arg Val Glu Glu Gly Val Asn Ala Tyr Trp Phe Arg Gly Leu Arg Pro 
545                 550                 555                 560 


Gly Thr Asn Tyr Ser Val Cys Leu Ala Leu Ala Gly Glu Ala Cys His 
                565                 570                 575     


Val Gln Val Val Phe Ser Thr Lys Lys Glu Leu Pro Ser Leu Leu Val 
            580                 585                 590         


Ile Val Ala Val Ser Val Phe Leu Leu Val Leu Ala Thr Val Pro Leu 
        595                 600                 605             


Leu Gly Ala Ala Cys Cys His Leu Leu Ala Lys His Pro Gly Lys Pro 
    610                 615                 620                 


Tyr Arg Leu Ile Leu Arg Pro Gln Ala Pro Asp Pro Met Glu Lys Arg 
625                 630                 635                 640 


Ile Ala Ala Asp Phe Asp Pro Arg Ala Ser Tyr Leu Glu Ser Glu Lys 
                645                 650                 655     


Ser Tyr Pro Ala Gly Gly Glu Ala Gly Gly Glu Glu Pro Glu Asp Val 
            660                 665                 670         


Gln Gly Glu Gly Leu Asp Glu Asp Ala Glu Gln Gly Asp Pro Ser Gly 
        675                 680                 685             


Asp Leu Gln Arg Glu Glu Ser Leu Ala Ala Cys Ser Leu Val Glu Ser 
    690                 695                 700                 


Gln Ser Lys Ala Asn Gln Glu Glu Phe Glu Ala Gly Ser Glu Tyr Ser 
705                 710                 715                 720 


Asp Arg Leu Pro Leu Gly Ala Glu Ala Val Asn Ile Ala Gln Glu Ile 
                725                 730                 735     


Asn Gly Asn Tyr Arg Gln Thr Ala Gly 
            740                 745 


<210>  1419
<211>  745
<212>  PRT
<213>  Homo sapiens

<400>  1419

Met Phe Pro Leu Arg Ala Leu Trp Leu Val Trp Ala Leu Leu Gly Val 
1               5                   10                  15      


Ala Gly Ser Cys Pro Glu Pro Cys Ala Cys Val Asp Lys Tyr Ala His 
            20                  25                  30          


Gln Phe Ala Asp Cys Ala Tyr Lys Glu Leu Arg Glu Val Pro Glu Gly 
        35                  40                  45              


Leu Pro Ala Asn Val Thr Thr Leu Ser Leu Ser Ala Asn Lys Ile Thr 
    50                  55                  60                  


Val Leu Arg Arg Gly Ala Phe Ala Asp Val Thr Gln Val Thr Ser Leu 
65                  70                  75                  80  


Trp Leu Ala His Asn Glu Val Arg Thr Val Glu Pro Gly Ala Leu Ala 
                85                  90                  95      


Val Leu Ser Gln Leu Lys Asn Leu Asp Leu Ser His Asn Phe Ile Ser 
            100                 105                 110         


Ser Phe Pro Trp Ser Asp Leu Arg Asn Leu Ser Ala Leu Gln Leu Leu 
        115                 120                 125             


Lys Met Asn His Asn Arg Leu Gly Ser Leu Pro Arg Asp Ala Leu Gly 
    130                 135                 140                 


Ala Leu Pro Asp Leu Arg Ser Leu Arg Ile Asn Asn Asn Arg Leu Arg 
145                 150                 155                 160 


Thr Leu Ala Pro Gly Thr Phe Asp Ala Leu Ser Ala Leu Ser His Leu 
                165                 170                 175     


Gln Leu Tyr His Asn Pro Phe His Cys Gly Cys Gly Leu Val Trp Leu 
            180                 185                 190         


Gln Ala Trp Ala Ala Ser Thr Arg Val Ser Leu Pro Glu Pro Asp Ser 
        195                 200                 205             


Ile Ala Cys Ala Ser Pro Pro Ala Leu Gln Gly Val Pro Val Tyr Arg 
    210                 215                 220                 


Leu Pro Ala Leu Pro Cys Ala Pro Pro Ser Val His Leu Ser Ala Glu 
225                 230                 235                 240 


Pro Pro Leu Glu Ala Pro Gly Thr Pro Leu Arg Ala Gly Leu Ala Phe 
                245                 250                 255     


Val Leu His Cys Ile Ala Asp Gly His Pro Thr Pro Arg Leu Gln Trp 
            260                 265                 270         


Gln Leu Gln Ile Pro Gly Gly Thr Val Val Leu Glu Pro Pro Val Leu 
        275                 280                 285             


Ser Gly Glu Asp Asp Gly Val Gly Ala Glu Glu Gly Glu Gly Glu Gly 
    290                 295                 300                 


Asp Gly Asp Leu Leu Thr Gln Thr Gln Ala Gln Thr Pro Thr Pro Ala 
305                 310                 315                 320 


Pro Ala Trp Pro Ala Pro Pro Ala Thr Pro Arg Phe Leu Ala Leu Ala 
                325                 330                 335     


Asn Gly Ser Leu Leu Val Pro Leu Leu Ser Ala Lys Glu Ala Gly Val 
            340                 345                 350         


Tyr Thr Cys Arg Ala His Asn Glu Leu Gly Ala Asn Ser Thr Ser Ile 
        355                 360                 365             


Arg Val Ala Val Ala Ala Thr Gly Pro Pro Lys His Ala Pro Gly Ala 
    370                 375                 380                 


Gly Gly Glu Pro Asp Gly Gln Ala Pro Thr Ser Glu Arg Lys Ser Thr 
385                 390                 395                 400 


Ala Lys Gly Arg Gly Asn Ser Val Leu Pro Ser Lys Pro Glu Gly Lys 
                405                 410                 415     


Ile Lys Gly Gln Gly Leu Ala Lys Val Ser Ile Leu Gly Glu Thr Glu 
            420                 425                 430         


Thr Glu Pro Glu Glu Asp Thr Ser Glu Gly Glu Glu Ala Glu Asp Gln 
        435                 440                 445             


Ile Leu Ala Asp Pro Ala Glu Glu Gln Arg Cys Gly Asn Gly Asp Pro 
    450                 455                 460                 


Ser Arg Tyr Val Ser Asn His Ala Phe Asn Gln Ser Ala Glu Leu Lys 
465                 470                 475                 480 


Pro His Val Phe Glu Leu Gly Val Ile Ala Leu Asp Val Ala Glu Arg 
                485                 490                 495     


Glu Ala Arg Val Gln Leu Thr Pro Leu Ala Ala Arg Trp Gly Pro Gly 
            500                 505                 510         


Pro Gly Gly Ala Gly Gly Ala Pro Arg Pro Gly Arg Arg Pro Leu Arg 
        515                 520                 525             


Leu Leu Tyr Leu Cys Pro Ala Gly Gly Gly Ala Ala Val Gln Trp Ser 
    530                 535                 540                 


Arg Val Glu Glu Gly Val Asn Ala Tyr Trp Phe Arg Gly Leu Arg Pro 
545                 550                 555                 560 


Gly Thr Asn Tyr Ser Val Cys Leu Ala Leu Ala Gly Glu Ala Cys His 
                565                 570                 575     


Val Gln Val Val Phe Ser Thr Lys Lys Glu Leu Pro Ser Leu Leu Val 
            580                 585                 590         


Ile Val Ala Val Ser Val Phe Leu Leu Val Leu Ala Thr Val Pro Leu 
        595                 600                 605             


Leu Gly Ala Ala Cys Cys His Leu Leu Ala Lys His Pro Gly Lys Pro 
    610                 615                 620                 


Tyr Arg Leu Ile Leu Arg Pro Gln Ala Pro Asp Pro Met Glu Lys Arg 
625                 630                 635                 640 


Ile Ala Ala Asp Phe Asp Pro Arg Ala Ser Tyr Leu Glu Ser Glu Lys 
                645                 650                 655     


Ser Tyr Pro Ala Gly Gly Glu Ala Gly Gly Glu Glu Pro Glu Asp Val 
            660                 665                 670         


Gln Gly Glu Gly Leu Asp Glu Asp Ala Glu Gln Gly Asp Pro Ser Gly 
        675                 680                 685             


Asp Leu Gln Arg Glu Glu Ser Leu Ala Ala Cys Ser Leu Val Glu Ser 
    690                 695                 700                 


Gln Ser Lys Ala Asn Gln Glu Glu Phe Glu Ala Gly Ser Glu Tyr Ser 
705                 710                 715                 720 


Asp Arg Leu Pro Leu Gly Ala Glu Ala Val Asn Ile Ala Gln Glu Ile 
                725                 730                 735     


Asn Gly Asn Tyr Arg Gln Thr Ala Gly 
            740                 745 


<210>  1420
<211>  745
<212>  PRT
<213>  Homo sapiens

<400>  1420

Met Phe Pro Leu Arg Ala Leu Trp Leu Val Trp Ala Leu Leu Gly Val 
1               5                   10                  15      


Ala Gly Ser Cys Pro Glu Pro Cys Ala Cys Val Asp Lys Tyr Ala His 
            20                  25                  30          


Gln Phe Ala Asp Cys Ala Tyr Lys Glu Leu Arg Glu Val Pro Glu Gly 
        35                  40                  45              


Leu Pro Ala Asn Val Thr Thr Leu Ser Leu Ser Ala Asn Lys Ile Thr 
    50                  55                  60                  


Val Leu Arg Arg Gly Ala Phe Ala Asp Val Thr Gln Val Thr Ser Leu 
65                  70                  75                  80  


Trp Leu Ala His Asn Glu Val Arg Thr Val Glu Pro Gly Ala Leu Ala 
                85                  90                  95      


Val Leu Ser Gln Leu Lys Asn Leu Asp Leu Ser His Asn Phe Ile Ser 
            100                 105                 110         


Ser Phe Pro Trp Ser Asp Leu Arg Asn Leu Ser Ala Leu Gln Leu Leu 
        115                 120                 125             


Lys Met Asn His Asn Arg Leu Gly Ser Leu Pro Arg Asp Ala Leu Gly 
    130                 135                 140                 


Ala Leu Pro Asp Leu Arg Ser Leu Arg Ile Asn Asn Asn Arg Leu Arg 
145                 150                 155                 160 


Thr Leu Ala Pro Gly Thr Phe Asp Ala Leu Ser Ala Leu Ser His Leu 
                165                 170                 175     


Gln Leu Tyr His Asn Pro Phe His Cys Gly Cys Gly Leu Val Trp Leu 
            180                 185                 190         


Gln Ala Trp Ala Ala Ser Thr Arg Val Ser Leu Pro Glu Pro Asp Ser 
        195                 200                 205             


Ile Ala Cys Ala Ser Pro Pro Ala Leu Gln Gly Val Pro Val Tyr Arg 
    210                 215                 220                 


Leu Pro Ala Leu Pro Cys Ala Pro Pro Ser Val His Leu Ser Ala Glu 
225                 230                 235                 240 


Pro Pro Leu Glu Ala Pro Gly Thr Pro Leu Arg Ala Gly Leu Ala Phe 
                245                 250                 255     


Val Leu His Cys Ile Ala Asp Gly His Pro Thr Pro Arg Leu Gln Trp 
            260                 265                 270         


Gln Leu Gln Ile Pro Gly Gly Thr Val Val Leu Glu Pro Pro Val Leu 
        275                 280                 285             


Ser Gly Glu Asp Asp Gly Val Gly Ala Glu Glu Gly Glu Gly Glu Gly 
    290                 295                 300                 


Asp Gly Asp Leu Leu Thr Gln Thr Gln Ala Gln Thr Pro Thr Pro Ala 
305                 310                 315                 320 


Pro Ala Trp Pro Ala Pro Pro Ala Thr Pro Arg Phe Leu Ala Leu Ala 
                325                 330                 335     


Asn Gly Ser Leu Leu Val Pro Leu Leu Ser Ala Lys Glu Ala Gly Val 
            340                 345                 350         


Tyr Thr Cys Arg Ala His Asn Glu Leu Gly Ala Asn Ser Thr Ser Ile 
        355                 360                 365             


Arg Val Ala Val Ala Ala Thr Gly Pro Pro Lys His Ala Pro Gly Ala 
    370                 375                 380                 


Gly Gly Glu Pro Asp Gly Gln Ala Pro Thr Ser Glu Arg Lys Ser Thr 
385                 390                 395                 400 


Ala Lys Gly Arg Gly Asn Ser Val Leu Pro Ser Lys Pro Glu Gly Lys 
                405                 410                 415     


Ile Lys Gly Gln Gly Leu Ala Lys Val Ser Ile Leu Gly Glu Thr Glu 
            420                 425                 430         


Thr Glu Pro Glu Glu Asp Thr Ser Glu Gly Glu Glu Ala Glu Asp Gln 
        435                 440                 445             


Ile Leu Ala Asp Pro Ala Glu Glu Gln Arg Cys Gly Asn Gly Asp Pro 
    450                 455                 460                 


Ser Arg Tyr Val Ser Asn His Ala Phe Asn Gln Ser Ala Glu Leu Lys 
465                 470                 475                 480 


Pro His Val Phe Glu Leu Gly Val Ile Ala Leu Asp Val Ala Glu Arg 
                485                 490                 495     


Glu Ala Arg Val Gln Leu Thr Pro Leu Ala Ala Arg Trp Gly Pro Gly 
            500                 505                 510         


Pro Gly Gly Ala Gly Gly Ala Pro Arg Pro Gly Arg Arg Pro Leu Arg 
        515                 520                 525             


Leu Leu Tyr Leu Cys Pro Ala Gly Gly Gly Ala Ala Val Gln Trp Ser 
    530                 535                 540                 


Arg Val Glu Glu Gly Val Asn Ala Tyr Trp Phe Arg Gly Leu Arg Pro 
545                 550                 555                 560 


Gly Thr Asn Tyr Ser Val Cys Leu Ala Leu Ala Gly Glu Ala Cys His 
                565                 570                 575     


Val Gln Val Val Phe Ser Thr Lys Lys Glu Leu Pro Ser Leu Leu Val 
            580                 585                 590         


Ile Val Ala Val Ser Val Phe Leu Leu Val Leu Ala Thr Val Pro Leu 
        595                 600                 605             


Leu Gly Ala Ala Cys Cys His Leu Leu Ala Lys His Pro Gly Lys Pro 
    610                 615                 620                 


Tyr Arg Leu Ile Leu Arg Pro Gln Ala Pro Asp Pro Met Glu Lys Arg 
625                 630                 635                 640 


Ile Ala Ala Asp Phe Asp Pro Arg Ala Ser Tyr Leu Glu Ser Glu Lys 
                645                 650                 655     


Ser Tyr Pro Ala Gly Gly Glu Ala Gly Gly Glu Glu Pro Glu Asp Val 
            660                 665                 670         


Gln Gly Glu Gly Leu Asp Glu Asp Ala Glu Gln Gly Asp Pro Ser Gly 
        675                 680                 685             


Asp Leu Gln Arg Glu Glu Ser Leu Ala Ala Cys Ser Leu Val Glu Ser 
    690                 695                 700                 


Gln Ser Lys Ala Asn Gln Glu Glu Phe Glu Ala Gly Ser Glu Tyr Ser 
705                 710                 715                 720 


Asp Arg Leu Pro Leu Gly Ala Glu Ala Val Asn Ile Ala Gln Glu Ile 
                725                 730                 735     


Asn Gly Asn Tyr Arg Gln Thr Ala Gly 
            740                 745 


<210>  1421
<211>  1303
<212>  PRT
<213>  Homo sapiens

<400>  1421

Met Pro Gly Pro Arg Gly Ala Ala Gly Gly Leu Ala Pro Glu Met Arg 
1               5                   10                  15      


Gly Ala Gly Ala Ala Gly Leu Leu Ala Leu Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Gly Leu Gly Gly Arg Val Glu Gly Gly Pro Ala Gly Glu 
        35                  40                  45              


Arg Gly Ala Gly Gly Gly Gly Ala Leu Ala Arg Glu Arg Phe Lys Val 
    50                  55                  60                  


Val Phe Ala Pro Val Ile Cys Lys Arg Thr Cys Leu Lys Gly Gln Cys 
65                  70                  75                  80  


Arg Asp Ser Cys Gln Gln Gly Ser Asn Met Thr Leu Ile Gly Glu Asn 
                85                  90                  95      


Gly His Ser Thr Asp Thr Leu Thr Gly Ser Gly Phe Arg Val Val Val 
            100                 105                 110         


Cys Pro Leu Pro Cys Met Asn Gly Gly Gln Cys Ser Ser Arg Asn Gln 
        115                 120                 125             


Cys Leu Cys Pro Pro Asp Phe Thr Gly Arg Phe Cys Gln Val Pro Ala 
    130                 135                 140                 


Gly Gly Ala Gly Gly Gly Thr Gly Gly Ser Gly Pro Gly Leu Ser Arg 
145                 150                 155                 160 


Thr Gly Ala Leu Ser Thr Gly Ala Leu Pro Pro Leu Ala Pro Glu Gly 
                165                 170                 175     


Asp Ser Val Ala Ser Lys His Ala Ile Tyr Ala Val Gln Val Ile Ala 
            180                 185                 190         


Asp Pro Pro Gly Pro Gly Glu Gly Pro Pro Ala Gln His Ala Ala Phe 
        195                 200                 205             


Leu Val Pro Leu Gly Pro Gly Gln Ile Ser Ala Glu Val Gln Ala Pro 
    210                 215                 220                 


Pro Pro Val Val Asn Val Arg Val His His Pro Pro Glu Ala Ser Val 
225                 230                 235                 240 


Gln Val His Arg Ile Glu Ser Ser Asn Ala Glu Ser Ala Ala Pro Ser 
                245                 250                 255     


Gln His Leu Leu Pro His Pro Lys Pro Ser His Pro Arg Pro Pro Thr 
            260                 265                 270         


Gln Lys Pro Leu Gly Arg Cys Phe Gln Asp Thr Leu Pro Lys Gln Pro 
        275                 280                 285             


Cys Gly Ser Asn Pro Leu Pro Gly Leu Thr Lys Gln Glu Asp Cys Cys 
    290                 295                 300                 


Gly Ser Ile Gly Thr Ala Trp Gly Gln Ser Lys Cys His Lys Cys Pro 
305                 310                 315                 320 


Gln Leu Gln Tyr Thr Gly Val Gln Lys Pro Gly Pro Val Arg Gly Glu 
                325                 330                 335     


Val Gly Ala Asp Cys Pro Gln Gly Tyr Lys Arg Leu Asn Ser Thr His 
            340                 345                 350         


Cys Gln Asp Ile Asn Glu Cys Ala Met Pro Gly Val Cys Arg His Gly 
        355                 360                 365             


Asp Cys Leu Asn Asn Pro Gly Ser Tyr Arg Cys Val Cys Pro Pro Gly 
    370                 375                 380                 


His Ser Leu Gly Pro Ser Arg Thr Gln Cys Ile Ala Asp Lys Pro Glu 
385                 390                 395                 400 


Glu Lys Ser Leu Cys Phe Arg Leu Val Ser Pro Glu His Gln Cys Gln 
                405                 410                 415     


His Pro Leu Thr Thr Arg Leu Thr Arg Gln Leu Cys Cys Cys Ser Val 
            420                 425                 430         


Gly Lys Ala Trp Gly Ala Arg Cys Gln Arg Cys Pro Thr Asp Gly Thr 
        435                 440                 445             


Ala Ala Phe Lys Glu Ile Cys Pro Ala Gly Lys Gly Tyr His Ile Leu 
    450                 455                 460                 


Thr Ser His Gln Thr Leu Thr Ile Gln Gly Glu Ser Asp Phe Ser Leu 
465                 470                 475                 480 


Phe Leu His Pro Asp Gly Pro Pro Lys Pro Gln Gln Leu Pro Glu Ser 
                485                 490                 495     


Pro Ser Gln Ala Pro Pro Pro Glu Asp Thr Glu Glu Glu Arg Gly Val 
            500                 505                 510         


Thr Thr Asp Ser Pro Val Ser Glu Glu Arg Ser Val Gln Gln Ser His 
        515                 520                 525             


Pro Thr Ala Thr Thr Thr Pro Ala Arg Pro Tyr Pro Glu Leu Ile Ser 
    530                 535                 540                 


Arg Pro Ser Pro Pro Thr Met Arg Trp Phe Leu Pro Asp Leu Pro Pro 
545                 550                 555                 560 


Ser Arg Ser Ala Val Glu Ile Ala Pro Thr Gln Val Thr Glu Thr Asp 
                565                 570                 575     


Glu Cys Arg Leu Asn Gln Asn Ile Cys Gly His Gly Glu Cys Val Pro 
            580                 585                 590         


Gly Pro Pro Asp Tyr Ser Cys His Cys Asn Pro Gly Tyr Arg Ser His 
        595                 600                 605             


Pro Gln His Arg Tyr Cys Val Asp Val Asn Glu Cys Glu Ala Glu Pro 
    610                 615                 620                 


Cys Gly Pro Gly Arg Gly Ile Cys Met Asn Thr Gly Gly Ser Tyr Asn 
625                 630                 635                 640 


Cys His Cys Asn Arg Gly Tyr Arg Leu His Val Gly Ala Gly Gly Arg 
                645                 650                 655     


Ser Cys Val Asp Leu Asn Glu Cys Ala Lys Pro His Leu Cys Gly Asp 
            660                 665                 670         


Gly Gly Phe Cys Ile Asn Phe Pro Gly His Tyr Lys Cys Asn Cys Tyr 
        675                 680                 685             


Pro Gly Tyr Arg Leu Lys Ala Ser Arg Pro Pro Val Cys Glu Asp Ile 
    690                 695                 700                 


Asp Glu Cys Arg Asp Pro Ser Ser Cys Pro Asp Gly Lys Cys Glu Asn 
705                 710                 715                 720 


Lys Pro Gly Ser Phe Lys Cys Ile Ala Cys Gln Pro Gly Tyr Arg Ser 
                725                 730                 735     


Gln Gly Gly Gly Ala Cys Arg Asp Val Asn Glu Cys Ala Glu Gly Ser 
            740                 745                 750         


Pro Cys Ser Pro Gly Trp Cys Glu Asn Leu Pro Gly Ser Phe Arg Cys 
        755                 760                 765             


Thr Cys Ala Gln Gly Tyr Ala Pro Ala Pro Asp Gly Arg Ser Cys Leu 
    770                 775                 780                 


Asp Val Asp Glu Cys Glu Ala Gly Asp Val Cys Asp Asn Gly Ile Cys 
785                 790                 795                 800 


Ser Asn Thr Pro Gly Ser Phe Gln Cys Gln Cys Leu Ser Gly Tyr His 
                805                 810                 815     


Leu Ser Arg Asp Arg Ser His Cys Glu Asp Ile Asp Glu Cys Asp Phe 
            820                 825                 830         


Pro Ala Ala Cys Ile Gly Gly Asp Cys Ile Asn Thr Asn Gly Ser Tyr 
        835                 840                 845             


Arg Cys Leu Cys Pro Gln Gly His Arg Leu Val Gly Gly Arg Lys Cys 
    850                 855                 860                 


Gln Asp Ile Asp Glu Cys Ser Gln Asp Pro Ser Leu Cys Leu Pro His 
865                 870                 875                 880 


Gly Ala Cys Lys Asn Leu Gln Gly Ser Tyr Val Cys Val Cys Asp Glu 
                885                 890                 895     


Gly Phe Thr Pro Thr Gln Asp Gln His Gly Cys Glu Glu Val Glu Gln 
            900                 905                 910         


Pro His His Lys Lys Glu Cys Tyr Leu Asn Phe Asp Asp Thr Val Phe 
        915                 920                 925             


Cys Asp Ser Val Leu Ala Thr Asn Val Thr Gln Gln Glu Cys Cys Cys 
    930                 935                 940                 


Ser Leu Gly Ala Gly Trp Gly Asp His Cys Glu Ile Tyr Pro Cys Pro 
945                 950                 955                 960 


Val Tyr Ser Ser Ala Glu Phe His Ser Leu Cys Pro Asp Gly Lys Gly 
                965                 970                 975     


Tyr Thr Gln Asp Asn Asn Ile Val Asn Tyr Gly Ile Pro Ala His Arg 
            980                 985                 990         


Asp Ile Asp Glu Cys Met Leu Phe  Gly Ser Glu Ile Cys  Lys Glu Gly 
        995                 1000                 1005             


Lys Cys  Val Asn Thr Gln Pro  Gly Tyr Glu Cys Tyr  Cys Lys Gln 
    1010                 1015                 1020             


Gly Phe  Tyr Tyr Asp Gly Asn  Leu Leu Glu Cys Val  Asp Val Asp 
    1025                 1030                 1035             


Glu Cys  Leu Asp Glu Ser Asn  Cys Arg Asn Gly Val  Cys Glu Asn 
    1040                 1045                 1050             


Thr Arg  Gly Gly Tyr Arg Cys  Ala Cys Thr Pro Pro  Ala Glu Tyr 
    1055                 1060                 1065             


Ser Pro  Ala Gln Arg Gln Cys  Leu Ser Pro Glu Glu  Met Asp Val 
    1070                 1075                 1080             


Asp Glu  Cys Gln Asp Pro Ala  Ala Cys Arg Pro Gly  Arg Cys Val 
    1085                 1090                 1095             


Asn Leu  Pro Gly Ser Tyr Arg  Cys Glu Cys Arg Pro  Pro Trp Val 
    1100                 1105                 1110             


Pro Gly  Pro Ser Gly Arg Asp  Cys Gln Leu Pro Glu  Ser Pro Ala 
    1115                 1120                 1125             


Glu Arg  Ala Pro Glu Arg Arg  Asp Val Cys Trp Ser  Gln Arg Gly 
    1130                 1135                 1140             


Glu Asp  Gly Met Cys Ala Gly  Pro Leu Ala Gly Pro  Ala Leu Thr 
    1145                 1150                 1155             


Phe Asp  Asp Cys Cys Cys Arg  Gln Gly Arg Gly Trp  Gly Ala Gln 
    1160                 1165                 1170             


Cys Arg  Pro Cys Pro Pro Arg  Gly Ala Gly Ser His  Cys Pro Thr 
    1175                 1180                 1185             


Ser Gln  Ser Glu Ser Asn Ser  Phe Trp Asp Thr Ser  Pro Leu Leu 
    1190                 1195                 1200             


Leu Gly  Lys Pro Pro Arg Asp  Glu Asp Ser Ser Glu  Glu Asp Ser 
    1205                 1210                 1215             


Asp Glu  Cys Arg Cys Val Ser  Gly Arg Cys Val Pro  Arg Pro Gly 
    1220                 1225                 1230             


Gly Ala  Val Cys Glu Cys Pro  Gly Gly Phe Gln Leu  Asp Ala Ser 
    1235                 1240                 1245             


Arg Ala  Arg Cys Val Asp Ile  Asp Glu Cys Arg Glu  Leu Asn Gln 
    1250                 1255                 1260             


Arg Gly  Leu Leu Cys Lys Ser  Glu Arg Cys Val Asn  Thr Ser Gly 
    1265                 1270                 1275             


Ser Phe  Arg Cys Val Cys Lys  Ala Gly Phe Ala Arg  Ser Arg Pro 
    1280                 1285                 1290             


His Gly  Ala Cys Val Pro Gln  Arg Arg Arg 
    1295                 1300             


<210>  1422
<211>  802
<212>  PRT
<213>  Homo sapiens

<400>  1422

Met Arg Ala Val Leu Ser Gln Lys Thr Thr Pro Leu Pro Arg Tyr Leu 
1               5                   10                  15      


Trp Pro Gly His Leu Ser Gly Pro Arg Arg Leu Thr Trp Ser Trp Cys 
            20                  25                  30          


Ser Asp His Arg Thr Pro Thr Cys Arg Glu Leu Gly Ser Pro His Pro 
        35                  40                  45              


Thr Pro Cys Thr Gly Pro Ala Arg Gly Trp Pro Arg Arg Gly Gly Gly 
    50                  55                  60                  


Pro Cys Gly Phe Thr Ser Ala Gly His Val Leu Cys Gly Tyr Pro Leu 
65                  70                  75                  80  


Cys Leu Leu Ser Gly Pro Ile Gln Gly Cys Gly Thr Gly Leu Gly Asp 
                85                  90                  95      


Ser Ser Met Ala Phe Leu Ser Arg Thr Ser Pro Val Ala Ala Ala Ser 
            100                 105                 110         


Phe Gln Ser Arg Gln Glu Ala Arg Gly Ser Ile Leu Leu Gln Ser Cys 
        115                 120                 125             


Gln Leu Pro Pro Gln Trp Leu Ser Thr Glu Ala Trp Thr Gly Glu Trp 
    130                 135                 140                 


Lys Gln Pro His Gly Gly Ala Leu Thr Ser Arg Ser Pro Gly Pro Val 
145                 150                 155                 160 


Ala Pro Gln Arg Pro Cys His Leu Lys Gly Trp Gln His Arg Pro Thr 
                165                 170                 175     


Gln His Asn Ala Ala Cys Lys Gln Gly Gln Ala Ala Ala Gln Thr Pro 
            180                 185                 190         


Pro Arg Pro Gly Pro Pro Ser Ala Pro Pro Pro Pro Pro Lys Glu Gly 
        195                 200                 205             


His Gln Glu Gly Leu Val Glu Leu Pro Ala Ser Phe Arg Glu Leu Leu 
    210                 215                 220                 


Thr Phe Phe Cys Thr Asn Ala Thr Ile His Gly Ala Ile Arg Leu Val 
225                 230                 235                 240 


Cys Ser Arg Gly Asn Arg Leu Lys Thr Thr Ser Trp Gly Leu Leu Ser 
                245                 250                 255     


Leu Gly Ala Leu Val Ala Leu Cys Trp Gln Leu Gly Leu Leu Phe Glu 
            260                 265                 270         


Arg His Trp His Arg Pro Val Leu Met Ala Val Ser Val His Ser Glu 
        275                 280                 285             


Arg Lys Leu Leu Pro Leu Val Thr Leu Cys Asp Gly Asn Pro Arg Arg 
    290                 295                 300                 


Pro Ser Pro Val Leu Arg His Leu Glu Leu Leu Asp Glu Phe Ala Arg 
305                 310                 315                 320 


Glu Asn Ile Asp Ser Leu Tyr Asn Val Asn Leu Ser Lys Gly Arg Ala 
                325                 330                 335     


Ala Leu Ser Ala Thr Val Pro Arg His Glu Pro Pro Phe His Leu Asp 
            340                 345                 350         


Arg Glu Ile Arg Leu Gln Arg Leu Ser His Ser Gly Ser Arg Val Arg 
        355                 360                 365             


Val Gly Phe Arg Leu Cys Asn Ser Thr Gly Gly Asp Cys Phe Tyr Arg 
    370                 375                 380                 


Gly Tyr Thr Ser Gly Val Ala Ala Val Gln Asp Trp Tyr His Phe His 
385                 390                 395                 400 


Tyr Val Asp Ile Leu Ala Leu Leu Pro Ala Ala Trp Glu Asp Ser His 
                405                 410                 415     


Gly Ser Gln Asp Gly His Phe Val Leu Ser Cys Ser Tyr Asp Gly Leu 
            420                 425                 430         


Asp Cys Gln Ala Arg Gln Phe Arg Thr Phe His His Pro Thr Tyr Gly 
        435                 440                 445             


Ser Cys Tyr Thr Val Asp Gly Val Trp Thr Ala Gln Arg Pro Gly Ile 
    450                 455                 460                 


Thr His Gly Val Gly Leu Val Leu Arg Val Glu Gln Gln Pro His Leu 
465                 470                 475                 480 


Pro Leu Leu Ser Thr Leu Ala Gly Ile Arg Val Met Val His Gly Arg 
                485                 490                 495     


Asn His Thr Pro Phe Leu Gly His His Ser Phe Ser Val Arg Pro Gly 
            500                 505                 510         


Thr Glu Ala Thr Ile Ser Ile Arg Glu Asp Glu Val His Arg Leu Gly 
        515                 520                 525             


Ser Pro Tyr Gly His Cys Thr Ala Gly Gly Glu Gly Val Glu Val Glu 
    530                 535                 540                 


Leu Leu His Asn Thr Ser Tyr Thr Arg Gln Ala Cys Leu Val Ser Cys 
545                 550                 555                 560 


Phe Gln Gln Leu Met Val Glu Thr Cys Ser Cys Gly Tyr Tyr Leu His 
                565                 570                 575     


Pro Leu Pro Ala Gly Ala Glu Tyr Cys Ser Ser Ala Arg His Pro Ala 
            580                 585                 590         


Trp Gly His Cys Phe Tyr Arg Leu Tyr Gln Asp Leu Glu Thr His Arg 
        595                 600                 605             


Leu Pro Cys Thr Ser Arg Cys Pro Arg Pro Cys Arg Glu Ser Ala Phe 
    610                 615                 620                 


Lys Leu Ser Thr Gly Thr Ser Arg Trp Pro Ser Ala Lys Ser Ala Gly 
625                 630                 635                 640 


Trp Thr Leu Ala Thr Leu Gly Glu Gln Gly Leu Pro His Gln Ser His 
                645                 650                 655     


Arg Gln Arg Ser Ser Leu Ala Lys Ile Asn Ile Val Tyr Gln Glu Leu 
            660                 665                 670         


Asn Tyr Arg Ser Val Glu Glu Ala Pro Val Tyr Ser Val Pro Gln Leu 
        675                 680                 685             


Leu Ser Ala Met Gly Ser Leu Cys Ser Leu Trp Phe Gly Ala Ser Val 
    690                 695                 700                 


Leu Ser Leu Leu Glu Leu Leu Glu Leu Leu Leu Asp Ala Ser Ala Leu 
705                 710                 715                 720 


Thr Leu Val Leu Gly Gly Arg Arg Leu Arg Arg Ala Trp Phe Ser Trp 
                725                 730                 735     


Pro Arg Ala Ser Pro Ala Ser Gly Ala Ser Ser Ile Lys Pro Glu Ala 
            740                 745                 750         


Ser Gln Met Pro Pro Pro Ala Gly Gly Thr Ser Asp Asp Pro Glu Pro 
        755                 760                 765             


Ser Gly Pro His Leu Pro Arg Val Met Leu Pro Gly Val Leu Ala Gly 
    770                 775                 780                 


Val Ser Ala Glu Glu Ser Trp Ala Gly Pro Gln Pro Leu Glu Thr Leu 
785                 790                 795                 800 


Asp Thr 
        


<210>  1423
<211>  279
<212>  PRT
<213>  Homo sapiens

<400>  1423

Met Phe Arg Ala Pro Cys His Arg Leu Arg Ala Arg Gly Thr Arg Lys 
1               5                   10                  15      


Ala Arg Ala Gly Ala Trp Arg Gly Cys Thr Phe Pro Cys Leu Gly Lys 
            20                  25                  30          


Gly Met Glu Arg Pro Ala Ala Arg Glu Pro His Gly Pro Asp Ala Leu 
        35                  40                  45              


Arg Arg Phe Gln Gly Leu Leu Leu Asp Arg Arg Gly Arg Leu His Gly 
    50                  55                  60                  


Gln Val Leu Arg Leu Arg Glu Val Ala Arg Arg Leu Glu Arg Leu Arg 
65                  70                  75                  80  


Arg Arg Ser Leu Val Ala Asn Val Ala Gly Ser Ser Leu Ser Ala Thr 
                85                  90                  95      


Gly Ala Leu Ala Ala Ile Val Gly Leu Ser Leu Ser Pro Val Thr Leu 
            100                 105                 110         


Gly Thr Ser Leu Leu Val Ser Ala Val Gly Leu Gly Val Ala Thr Ala 
        115                 120                 125             


Gly Gly Ala Val Thr Ile Thr Ser Asp Leu Ser Leu Ile Phe Cys Asn 
    130                 135                 140                 


Ser Arg Glu Leu Arg Arg Val Gln Glu Ile Ala Ala Thr Cys Gln Asp 
145                 150                 155                 160 


Gln Met Arg Glu Ile Leu Ser Cys Leu Glu Phe Phe Cys Arg Trp Gln 
                165                 170                 175     


Gly Cys Gly Asp Arg Gln Leu Leu Gln Cys Gly Arg Asn Ala Ser Ile 
            180                 185                 190         


Ala Leu Tyr Asn Ser Val Tyr Phe Ile Val Phe Phe Gly Ser Arg Gly 
        195                 200                 205             


Phe Leu Ile Pro Arg Arg Ala Glu Gly Asp Thr Lys Val Ser Gln Ala 
    210                 215                 220                 


Val Leu Lys Ala Lys Ile Gln Lys Leu Ala Glu Ser Leu Glu Ser Cys 
225                 230                 235                 240 


Thr Gly Ala Leu Asp Glu Leu Ser Glu Gln Leu Glu Ser Arg Val Gln 
                245                 250                 255     


Leu Cys Thr Lys Ser Ser Arg Gly His Asp Leu Lys Ile Ser Ala Asp 
            260                 265                 270         


Gln Arg Ala Gly Leu Phe Phe 
        275                 


<210>  1424
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  1424

Met Glu Arg Gly Ile Ser Asp Val Thr Asp Arg Lys Leu Thr Met Glu 
1               5                   10                  15      


Glu Glu Glu Ala Lys Arg Ile Ala Glu Met Gly Lys Pro Val Leu Gly 
            20                  25                  30          


Glu His Pro Lys Leu Glu Val Ile Ile Glu Glu Ser Tyr Glu Phe Lys 
        35                  40                  45              


Thr Thr Val Asp Lys Leu Ile Lys Lys Thr Asn Leu Ala Leu Val Val 
    50                  55                  60                  


Gly Thr His Ser Trp Arg Asp Gln Phe Met Glu Ala Ile Thr Val Ser 
65                  70                  75                  80  


Ala Ala Gly Asp Glu Asp Glu Asp Glu Ser Gly Glu Glu Arg Leu Pro 
                85                  90                  95      


Ser Cys Phe Asp Tyr Val Met His Phe Leu Thr Val Phe Trp Lys Val 
            100                 105                 110         


Leu Phe Ala Cys Val Pro Pro Thr Glu Tyr Cys His Gly Trp Ala Cys 
        115                 120                 125             


Phe Ala Val Ser Ile Leu Ile Ile Gly Met Leu Thr Ala Ile Ile Gly 
    130                 135                 140                 


Asp Leu Ala Ser His Phe Gly Cys Thr Ile Gly Leu Lys Asp Ser Val 
145                 150                 155                 160 


Thr Ala Val Val Phe Val Ala Phe Gly Thr Ser Val Pro Asp Thr Phe 
                165                 170                 175     


Ala Ser Lys Ala Ala Ala Leu Gln Asp Val Tyr Ala Asp Ala Ser Ile 
            180                 185                 190         


Gly Asn Val Thr Gly Ser Asn Ala Val Asn Val Phe Leu Gly Ile Gly 
        195                 200                 205             


Leu Ala Trp Ser Val Ala Ala Ile Tyr Trp Ala Leu Gln Gly Gln Glu 
    210                 215                 220                 


Phe His Val Ser Ala Gly Thr Leu Ala Phe Ser Val Thr Leu Phe Thr 
225                 230                 235                 240 


Ile Phe Ala Phe Val Cys Ile Ser Val Leu Leu Tyr Arg Arg Arg Pro 
                245                 250                 255     


His Leu Gly Gly Glu Leu Gly Gly Pro Arg Gly Cys Lys Leu Ala Thr 
            260                 265                 270         


Thr Trp Leu Phe Val Ser Leu Trp Leu Leu Tyr Ile Leu Phe Ala Thr 
        275                 280                 285             


Leu Glu Ala Tyr Cys Tyr Ile Lys Gly Phe 
    290                 295             


<210>  1425
<211>  2081
<212>  PRT
<213>  Homo sapiens

<400>  1425

Met Leu Cys Cys Leu Leu Val Arg Ala Ser Asn Leu Pro Ser Ala Lys 
1               5                   10                  15      


Lys Asp Arg Arg Ser Asp Pro Val Ala Ser Leu Thr Phe Arg Gly Val 
            20                  25                  30          


Lys Lys Arg Thr Lys Val Ile Lys Asn Ser Val Asn Pro Val Trp Asn 
        35                  40                  45              


Glu Gly Phe Glu Trp Asp Leu Lys Gly Ile Pro Leu Asp Gln Gly Ser 
    50                  55                  60                  


Glu Leu His Val Val Val Lys Asp His Glu Thr Met Gly Arg Asn Arg 
65                  70                  75                  80  


Phe Leu Gly Glu Ala Lys Val Pro Leu Arg Glu Val Leu Ala Thr Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Phe Asn Ala Pro Leu Leu Asp Thr Lys Lys Gln 
            100                 105                 110         


Pro Thr Gly Ala Ser Leu Val Leu Gln Val Ser Tyr Thr Pro Leu Pro 
        115                 120                 125             


Gly Ala Val Pro Leu Phe Pro Pro Pro Thr Pro Leu Glu Pro Ser Pro 
    130                 135                 140                 


Thr Leu Pro Asp Leu Asp Val Val Ala Asp Thr Gly Gly Glu Glu Asp 
145                 150                 155                 160 


Thr Glu Asp Gln Gly Leu Thr Gly Asp Glu Ala Glu Pro Phe Leu Asp 
                165                 170                 175     


Gln Ser Gly Gly Pro Gly Ala Pro Thr Thr Pro Arg Lys Leu Pro Ser 
            180                 185                 190         


Arg Pro Pro Pro His Tyr Pro Gly Ile Lys Arg Lys Arg Ser Ala Pro 
        195                 200                 205             


Thr Ser Arg Lys Leu Leu Ser Asp Lys Pro Gln Asp Phe Gln Ile Arg 
    210                 215                 220                 


Val Gln Val Ile Glu Gly Arg Gln Leu Pro Gly Val Asn Ile Lys Pro 
225                 230                 235                 240 


Val Val Lys Val Thr Ala Ala Gly Gln Thr Lys Arg Thr Arg Ile His 
                245                 250                 255     


Lys Gly Asn Ser Pro Leu Phe Asn Glu Thr Leu Phe Phe Asn Leu Phe 
            260                 265                 270         


Asp Ser Pro Gly Glu Leu Phe Asp Glu Pro Ile Phe Ile Thr Val Val 
        275                 280                 285             


Asp Ser Arg Ser Leu Arg Thr Asp Ala Leu Leu Gly Glu Phe Arg Met 
    290                 295                 300                 


Asp Val Gly Thr Ile Tyr Arg Glu Pro Arg His Ala Tyr Leu Arg Lys 
305                 310                 315                 320 


Trp Leu Leu Leu Ser Asp Pro Asp Asp Phe Ser Ala Gly Ala Arg Gly 
                325                 330                 335     


Tyr Leu Lys Thr Ser Leu Cys Val Leu Gly Pro Gly Asp Glu Ala Pro 
            340                 345                 350         


Leu Glu Arg Lys Asp Pro Ser Glu Asp Lys Glu Asp Ile Glu Ser Asn 
        355                 360                 365             


Leu Leu Arg Pro Thr Gly Val Ala Leu Arg Gly Ala His Phe Cys Leu 
    370                 375                 380                 


Lys Val Phe Arg Ala Glu Asp Leu Pro Gln Met Asp Asp Ala Val Met 
385                 390                 395                 400 


Asp Asn Val Lys Gln Ile Phe Gly Phe Glu Ser Asn Lys Lys Asn Leu 
                405                 410                 415     


Val Asp Pro Phe Val Glu Val Ser Phe Ala Gly Lys Met Leu Cys Ser 
            420                 425                 430         


Lys Ile Leu Glu Lys Thr Ala Asn Pro Gln Trp Asn Gln Asn Ile Thr 
        435                 440                 445             


Leu Pro Ala Met Phe Pro Ser Met Cys Glu Lys Met Arg Ile Arg Ile 
    450                 455                 460                 


Ile Asp Trp Asp Arg Leu Thr His Asn Asp Ile Val Ala Thr Thr Tyr 
465                 470                 475                 480 


Leu Ser Met Ser Lys Ile Ser Ala Pro Gly Gly Glu Ile Glu Glu Glu 
                485                 490                 495     


Pro Ala Gly Ala Val Lys Pro Ser Lys Ala Ser Asp Leu Asp Asp Tyr 
            500                 505                 510         


Leu Gly Phe Leu Pro Thr Phe Gly Pro Cys Tyr Ile Asn Leu Tyr Gly 
        515                 520                 525             


Ser Pro Arg Glu Phe Thr Gly Phe Pro Asp Pro Tyr Thr Glu Leu Asn 
    530                 535                 540                 


Thr Gly Lys Gly Glu Gly Val Ala Tyr Arg Gly Arg Leu Leu Leu Ser 
545                 550                 555                 560 


Leu Glu Thr Lys Leu Val Glu His Ser Glu Gln Lys Val Glu Asp Leu 
                565                 570                 575     


Pro Ala Asp Asp Ile Leu Arg Val Glu Lys Tyr Leu Arg Arg Arg Lys 
            580                 585                 590         


Tyr Ser Leu Phe Ala Ala Phe Tyr Ser Ala Thr Met Leu Gln Asp Val 
        595                 600                 605             


Asp Asp Ala Ile Gln Phe Glu Val Ser Ile Gly Asn Tyr Gly Asn Lys 
    610                 615                 620                 


Phe Asp Met Thr Cys Leu Pro Leu Ala Ser Thr Thr Gln Tyr Ser Arg 
625                 630                 635                 640 


Ala Val Phe Asp Gly Cys His Tyr Tyr Tyr Leu Pro Trp Gly Asn Val 
                645                 650                 655     


Lys Pro Val Val Val Leu Ser Ser Tyr Trp Glu Asp Ile Ser His Arg 
            660                 665                 670         


Ile Glu Thr Gln Asn Gln Leu Leu Gly Ile Ala Asp Arg Leu Glu Ala 
        675                 680                 685             


Gly Leu Glu Gln Val His Leu Ala Leu Lys Ala Gln Cys Ser Thr Glu 
    690                 695                 700                 


Asp Val Asp Ser Leu Val Ala Gln Leu Thr Asp Glu Leu Ile Ala Gly 
705                 710                 715                 720 


Cys Ser Gln Pro Leu Gly Asp Ile His Glu Thr Pro Ser Ala Thr His 
                725                 730                 735     


Leu Asp Gln Tyr Leu Tyr Gln Leu Arg Thr His His Leu Ser Gln Ile 
            740                 745                 750         


Thr Glu Ala Ala Leu Ala Leu Lys Leu Gly His Ser Glu Leu Pro Ala 
        755                 760                 765             


Ala Leu Glu Gln Ala Glu Asp Trp Leu Leu Arg Leu Arg Ala Leu Ala 
    770                 775                 780                 


Glu Glu Pro Gln Asn Ser Leu Pro Asp Ile Val Ile Trp Met Leu Gln 
785                 790                 795                 800 


Gly Asp Lys Arg Val Ala Tyr Gln Arg Val Pro Ala His Gln Val Leu 
                805                 810                 815     


Phe Ser Arg Arg Gly Ala Asn Tyr Cys Gly Lys Asn Cys Gly Lys Leu 
            820                 825                 830         


Gln Thr Ile Phe Leu Lys Tyr Pro Met Glu Lys Val Pro Gly Ala Arg 
        835                 840                 845             


Met Pro Val Gln Ile Arg Val Lys Leu Trp Phe Gly Leu Ser Val Asp 
    850                 855                 860                 


Glu Lys Glu Phe Asn Gln Phe Ala Glu Gly Lys Leu Ser Val Phe Ala 
865                 870                 875                 880 


Glu Thr Tyr Glu Asn Glu Thr Lys Leu Ala Leu Val Gly Asn Trp Gly 
                885                 890                 895     


Thr Thr Gly Leu Thr Tyr Pro Lys Phe Ser Asp Val Thr Gly Lys Ile 
            900                 905                 910         


Lys Leu Pro Lys Asp Ser Phe Arg Pro Ser Ala Gly Trp Thr Trp Ala 
        915                 920                 925             


Gly Asp Trp Phe Val Cys Pro Glu Lys Thr Leu Leu His Asp Met Asp 
    930                 935                 940                 


Ala Gly His Leu Ser Phe Val Glu Glu Val Phe Glu Asn Gln Thr Arg 
945                 950                 955                 960 


Leu Pro Gly Gly Gln Trp Ile Tyr Met Ser Asp Asn Tyr Thr Asp Val 
                965                 970                 975     


Asn Gly Glu Lys Val Leu Pro Lys Asp Asp Ile Glu Cys Pro Leu Gly 
            980                 985                 990         


Trp Lys Trp Glu Asp Glu Glu Trp  Ser Thr Asp Leu Asn  Arg Ala Val 
        995                 1000                 1005             


Asp Glu  Gln Gly Trp Glu Tyr  Ser Ile Thr Ile Pro  Pro Glu Arg 
    1010                 1015                 1020             


Lys Pro  Lys His Trp Val Pro  Ala Glu Lys Met Tyr  Tyr Thr His 
    1025                 1030                 1035             


Arg Arg  Arg Arg Trp Val Arg  Leu Arg Arg Arg Asp  Leu Ser Gln 
    1040                 1045                 1050             


Met Glu  Ala Leu Lys Arg His  Arg Gln Ala Glu Ala  Glu Gly Glu 
    1055                 1060                 1065             


Gly Trp  Glu Tyr Ala Ser Leu  Phe Gly Trp Lys Phe  His Leu Glu 
    1070                 1075                 1080             


Tyr Arg  Lys Thr Asp Ala Phe  Arg Arg Arg Arg Trp  Arg Arg Arg 
    1085                 1090                 1095             


Met Glu  Pro Leu Glu Lys Thr  Gly Pro Ala Ala Val  Phe Ala Leu 
    1100                 1105                 1110             


Glu Gly  Ala Leu Gly Gly Val  Met Asp Asp Lys Ser  Glu Asp Ser 
    1115                 1120                 1125             


Met Ser  Val Ser Thr Leu Ser  Phe Gly Val Asn Arg  Pro Thr Ile 
    1130                 1135                 1140             


Ser Cys  Ile Phe Asp Tyr Gly  Asn Arg Tyr His Leu  Arg Cys Tyr 
    1145                 1150                 1155             


Met Tyr  Gln Ala Arg Asp Leu  Ala Ala Met Asp Lys  Asp Ser Phe 
    1160                 1165                 1170             


Ser Asp  Pro Tyr Ala Ile Val  Ser Phe Leu His Gln  Ser Gln Lys 
    1175                 1180                 1185             


Thr Val  Val Val Lys Asn Thr  Leu Asn Pro Thr Trp  Asp Gln Thr 
    1190                 1195                 1200             


Leu Ile  Phe Tyr Glu Ile Glu  Ile Phe Gly Glu Pro  Ala Thr Val 
    1205                 1210                 1215             


Ala Glu  Gln Pro Pro Ser Ile  Val Val Glu Leu Tyr  Asp His Asp 
    1220                 1225                 1230             


Thr Tyr  Gly Ala Asp Glu Phe  Met Gly Arg Cys Ile  Cys Gln Pro 
    1235                 1240                 1245             


Ser Leu  Glu Arg Met Pro Arg  Leu Ala Trp Phe Pro  Leu Thr Arg 
    1250                 1255                 1260             


Gly Ser  Gln Pro Ser Gly Glu  Leu Leu Ala Ser Phe  Glu Leu Ile 
    1265                 1270                 1275             


Gln Arg  Glu Lys Pro Ala Ile  His His Ile Pro Gly  Phe Glu Val 
    1280                 1285                 1290             


Gln Glu  Thr Ser Arg Ile Leu  Asp Glu Ser Glu Asp  Thr Asp Leu 
    1295                 1300                 1305             


Pro Tyr  Pro Pro Pro Gln Arg  Glu Ala Asn Ile Tyr  Met Val Pro 
    1310                 1315                 1320             


Gln Asn  Ile Lys Pro Ala Leu  Gln Arg Thr Ala Ile  Glu Ile Leu 
    1325                 1330                 1335             


Ala Trp  Gly Leu Arg Asn Met  Lys Ser Tyr Gln Leu  Ala Asn Ile 
    1340                 1345                 1350             


Ser Ser  Pro Ser Leu Val Val  Glu Cys Gly Gly Gln  Thr Val Gln 
    1355                 1360                 1365             


Ser Cys  Val Ile Arg Asn Leu  Arg Lys Asn Pro Asn  Phe Asp Ile 
    1370                 1375                 1380             


Cys Thr  Leu Phe Met Glu Val  Met Leu Pro Arg Glu  Glu Leu Tyr 
    1385                 1390                 1395             


Cys Pro  Pro Ile Thr Val Lys  Val Ile Asp Asn Arg  Gln Phe Gly 
    1400                 1405                 1410             


Arg Arg  Pro Val Val Gly Gln  Cys Thr Ile Arg Ser  Leu Glu Ser 
    1415                 1420                 1425             


Phe Leu  Cys Asp Pro Tyr Ser  Ala Glu Ser Pro Ser  Pro Gln Gly 
    1430                 1435                 1440             


Gly Pro  Asp Asp Val Ser Leu  Leu Ser Pro Gly Glu  Asp Val Leu 
    1445                 1450                 1455             


Ile Asp  Ile Asp Asp Lys Glu  Pro Leu Ile Pro Ile  Gln Glu Glu 
    1460                 1465                 1470             


Glu Phe  Ile Asp Trp Trp Ser  Lys Phe Phe Ala Ser  Ile Gly Glu 
    1475                 1480                 1485             


Arg Glu  Lys Cys Gly Ser Tyr  Leu Glu Lys Asp Phe  Asp Thr Leu 
    1490                 1495                 1500             


Lys Val  Tyr Asp Thr Gln Leu  Glu Asn Val Glu Ala  Phe Glu Gly 
    1505                 1510                 1515             


Leu Ser  Asp Phe Cys Asn Thr  Phe Lys Leu Tyr Arg  Gly Lys Thr 
    1520                 1525                 1530             


Gln Glu  Glu Thr Glu Asp Pro  Ser Val Ile Gly Glu  Phe Lys Gly 
    1535                 1540                 1545             


Leu Phe  Lys Ile Tyr Pro Leu  Pro Glu Asp Pro Ala  Ile Pro Met 
    1550                 1555                 1560             


Pro Pro  Arg Gln Phe His Gln  Leu Ala Ala Gln Gly  Pro Gln Glu 
    1565                 1570                 1575             


Cys Leu  Val Arg Ile Tyr Ile  Val Arg Ala Phe Gly  Leu Gln Pro 
    1580                 1585                 1590             


Lys Asp  Pro Asn Gly Lys Cys  Asp Pro Tyr Ile Lys  Ile Ser Ile 
    1595                 1600                 1605             


Gly Lys  Lys Ser Val Ser Asp  Gln Asp Asn Tyr Ile  Pro Cys Thr 
    1610                 1615                 1620             


Leu Glu  Pro Val Phe Gly Lys  Met Phe Glu Leu Thr  Cys Thr Leu 
    1625                 1630                 1635             


Pro Leu  Glu Lys Asp Leu Lys  Ile Thr Leu Tyr Asp  Tyr Asp Leu 
    1640                 1645                 1650             


Leu Ser  Lys Asp Glu Lys Ile  Gly Glu Thr Val Val  Asp Leu Glu 
    1655                 1660                 1665             


Asn Arg  Leu Leu Ser Lys Phe  Gly Ala Arg Cys Gly  Leu Pro Gln 
    1670                 1675                 1680             


Thr Tyr  Cys Val Ser Gly Pro  Asn Gln Trp Arg Asp  Gln Leu Arg 
    1685                 1690                 1695             


Pro Ser  Gln Leu Leu His Leu  Phe Cys Gln Gln His  Arg Val Lys 
    1700                 1705                 1710             


Ala Pro  Val Tyr Arg Thr Asp  Arg Val Met Phe Gln  Asp Lys Glu 
    1715                 1720                 1725             


Tyr Ser  Ile Glu Glu Ile Glu  Ala Gly Arg Ile Pro  Asn Pro His 
    1730                 1735                 1740             


Leu Gly  Pro Val Glu Glu Arg  Leu Ala Leu His Val  Leu Gln Gln 
    1745                 1750                 1755             


Gln Gly  Leu Val Pro Glu His  Val Glu Ser Arg Pro  Leu Tyr Ser 
    1760                 1765                 1770             


Pro Leu  Gln Pro Asp Ile Glu  Gln Gly Lys Leu Gln  Met Trp Val 
    1775                 1780                 1785             


Asp Leu  Phe Pro Lys Ala Leu  Gly Arg Pro Gly Pro  Pro Phe Asn 
    1790                 1795                 1800             


Ile Thr  Pro Arg Arg Ala Arg  Arg Phe Phe Leu Arg  Cys Ile Ile 
    1805                 1810                 1815             


Trp Asn  Thr Arg Asp Val Ile  Leu Asp Asp Leu Ser  Leu Thr Gly 
    1820                 1825                 1830             


Glu Lys  Met Ser Asp Ile Tyr  Val Lys Gly Trp Met  Ile Gly Phe 
    1835                 1840                 1845             


Glu Glu  His Lys Gln Lys Thr  Asp Val His Tyr Arg  Ser Leu Gly 
    1850                 1855                 1860             


Gly Glu  Gly Asn Phe Asn Trp  Arg Phe Ile Phe Pro  Phe Asp Tyr 
    1865                 1870                 1875             


Leu Pro  Ala Glu Gln Val Cys  Thr Ile Ala Lys Lys  Asp Ala Phe 
    1880                 1885                 1890             


Trp Arg  Leu Asp Lys Thr Glu  Ser Lys Ile Pro Ala  Arg Val Val 
    1895                 1900                 1905             


Phe Gln  Ile Trp Asp Asn Asp  Lys Phe Ser Phe Asp  Asp Phe Leu 
    1910                 1915                 1920             


Gly Ser  Leu Gln Leu Asp Leu  Asn Arg Met Pro Lys  Pro Ala Lys 
    1925                 1930                 1935             


Thr Ala  Lys Lys Cys Ser Leu  Asp Gln Leu Asp Asp  Ala Phe His 
    1940                 1945                 1950             


Pro Glu  Trp Phe Val Ser Leu  Phe Glu Gln Lys Thr  Val Lys Gly 
    1955                 1960                 1965             


Trp Trp  Pro Cys Val Ala Glu  Glu Gly Glu Lys Lys  Ile Leu Ala 
    1970                 1975                 1980             


Gly Lys  Leu Glu Met Thr Leu  Glu Ile Val Ala Glu  Ser Glu His 
    1985                 1990                 1995             


Glu Glu  Arg Pro Ala Gly Gln  Gly Arg Asp Glu Pro  Asn Met Asn 
    2000                 2005                 2010             


Pro Lys  Leu Glu Asp Pro Arg  Arg Pro Asp Thr Ser  Phe Leu Trp 
    2015                 2020                 2025             


Phe Thr  Ser Pro Tyr Lys Thr  Met Lys Phe Ile Leu  Trp Arg Arg 
    2030                 2035                 2040             


Phe Arg  Trp Ala Ile Ile Leu  Phe Ile Ile Leu Phe  Ile Leu Leu 
    2045                 2050                 2055             


Leu Phe  Leu Ala Ile Phe Ile  Tyr Ala Phe Pro Asn  Tyr Ala Ala 
    2060                 2065                 2070             


Met Lys  Leu Val Lys Pro Phe  Ser 
    2075                 2080     


<210>  1426
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  1426

Met Pro Pro Lys Arg Asn Glu Lys Tyr Lys Leu Pro Ile Pro Phe Pro 
1               5                   10                  15      


Glu Gly Lys Val Leu Asp Asp Met Glu Gly Asn Gln Trp Val Leu Gly 
            20                  25                  30          


Lys Lys Ile Gly Ser Gly Gly Phe Gly Leu Ile Tyr Leu Ala Phe Pro 
        35                  40                  45              


Thr Asn Lys Pro Glu Lys Asp Ala Arg His Val Val Lys Val Glu Tyr 
    50                  55                  60                  


Gln Glu Asn Gly Pro Leu Phe Ser Glu Leu Lys Phe Tyr Gln Arg Val 
65                  70                  75                  80  


Ala Lys Lys Asp Cys Ile Lys Lys Trp Ile Glu Arg Lys Gln Leu Asp 
                85                  90                  95      


Tyr Leu Gly Ile Pro Leu Phe Tyr Gly Ser Gly Leu Thr Glu Phe Lys 
            100                 105                 110         


Gly Arg Ser Tyr Arg Phe Met Val Met Glu Arg Leu Gly Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Ser Gly Gln Asn Gly Thr Phe Lys Lys Ser Thr Val Leu 
    130                 135                 140                 


Gln Leu Gly Ile Arg Met Leu Asp Val Leu Glu Tyr Ile His Glu Asn 
145                 150                 155                 160 


Glu Tyr Val His Gly Asp Ile Lys Ala Ala Asn Leu Leu Leu Gly Tyr 
                165                 170                 175     


Lys Asn Pro Asp Gln Val Tyr Leu Ala Asp Tyr Gly Leu Ser Tyr Arg 
            180                 185                 190         


Tyr Cys Pro Asn Gly Asn His Lys Gln Tyr Gln Glu Asn Pro Arg Lys 
        195                 200                 205             


Gly His Asn Gly Thr Ile Glu Phe Thr Ser Leu Asp Ala His Lys Gly 
    210                 215                 220                 


Val Ala Leu Ser Arg Arg Ser Asp Val Glu Ile Leu Gly Tyr Cys Met 
225                 230                 235                 240 


Leu Arg Trp Leu Cys Gly Lys Leu Pro Trp Glu Gln Asn Leu Lys Asp 
                245                 250                 255     


Pro Val Ala Val Gln Thr Ala Lys Thr Asn Leu Leu Asp Glu Leu Pro 
            260                 265                 270         


Gln Ser Val Leu Lys Trp Ala Pro Ser Gly Ser Ser Cys Cys Glu Ile 
        275                 280                 285             


Ala Gln Phe Leu Val Cys Ala His Ser Leu Ala Tyr Asp Glu Lys Pro 
    290                 295                 300                 


Asn Tyr Gln Ala Leu Lys Lys Ile Leu Asn Pro His Gly Ile Pro Leu 
305                 310                 315                 320 


Gly Pro Leu Asp Phe Ser Thr Lys Gly Gln Ser Ile Asn Val His Thr 
                325                 330                 335     


Pro Asn Ser Gln Lys Val Asp Ser Gln Lys Ala Ala Thr Lys Gln Val 
            340                 345                 350         


Asn Lys Ala His Asn Arg Leu Ile Glu Lys Lys Val His Ser Glu Arg 
        355                 360                 365             


Ser Ala Glu Ser Cys Ala Thr Trp Lys Val Gln Lys Glu Glu Lys Leu 
    370                 375                 380                 


Ile Gly Leu Met Asn Asn Glu Ala Ala Gln Glu Ser Thr Arg Arg Arg 
385                 390                 395                 400 


Gln Lys Tyr Gln Glu Ser Gln Glu Pro Leu Asn Glu Val Asn Ser Phe 
                405                 410                 415     


Pro Gln Lys Ile Ser Tyr Thr Gln Phe Pro Asn Ser Phe Tyr Glu Pro 
            420                 425                 430         


His Gln Asp Phe Thr Ser Pro Asp Ile Phe Lys Lys Ser Arg Ser Pro 
        435                 440                 445             


Ser Trp Tyr Lys Tyr Thr Ser Thr Val Ser Thr Gly Ile Thr Asp Leu 
    450                 455                 460                 


Glu Ser Ser Thr Gly Leu Trp Pro Thr Ile Ser Gln Phe Thr Leu Ser 
465                 470                 475                 480 


Glu Glu Thr Asn Ala Asp Val Tyr Tyr Tyr Arg Ile Ile Ile Pro Val 
                485                 490                 495     


Leu Leu Met Leu Val Phe Leu Ala Leu Phe Phe Leu 
            500                 505             


<210>  1427
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  1427

Met Pro Pro Lys Arg Asn Glu Lys Tyr Lys Leu Pro Ile Pro Phe Pro 
1               5                   10                  15      


Glu Gly Lys Val Leu Asp Asp Met Glu Gly Asn Gln Trp Val Leu Gly 
            20                  25                  30          


Lys Lys Ile Gly Ser Gly Gly Phe Gly Leu Ile Tyr Leu Ala Phe Pro 
        35                  40                  45              


Thr Asn Lys Pro Glu Lys Asp Ala Arg His Val Val Lys Val Glu Tyr 
    50                  55                  60                  


Gln Glu Asn Gly Pro Leu Phe Ser Glu Leu Lys Phe Tyr Gln Arg Val 
65                  70                  75                  80  


Ala Lys Lys Asp Cys Ile Lys Lys Trp Ile Glu Arg Lys Gln Leu Asp 
                85                  90                  95      


Tyr Leu Gly Ile Pro Leu Phe Tyr Gly Ser Gly Leu Thr Glu Phe Lys 
            100                 105                 110         


Gly Arg Ser Tyr Arg Phe Met Val Met Glu Arg Leu Gly Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Ser Gly Gln Asn Gly Thr Phe Lys Lys Ser Thr Val Leu 
    130                 135                 140                 


Gln Leu Gly Ile Arg Met Leu Asp Val Leu Glu Tyr Ile His Glu Asn 
145                 150                 155                 160 


Glu Tyr Val His Gly Asp Ile Lys Ala Ala Asn Leu Leu Leu Gly Tyr 
                165                 170                 175     


Lys Asn Pro Asp Gln Val Tyr Leu Ala Asp Tyr Gly Leu Ser Tyr Arg 
            180                 185                 190         


Tyr Cys Pro Asn Gly Asn His Lys Gln Tyr Gln Glu Asn Pro Arg Lys 
        195                 200                 205             


Gly His Asn Gly Thr Ile Glu Phe Thr Ser Leu Asp Ala His Lys Gly 
    210                 215                 220                 


Val Ala Leu Ser Arg Arg Ser Asp Val Glu Ile Leu Gly Tyr Cys Met 
225                 230                 235                 240 


Leu Arg Trp Leu Cys Gly Lys Leu Pro Trp Glu Gln Asn Leu Lys Asp 
                245                 250                 255     


Pro Val Ala Val Gln Thr Ala Lys Thr Asn Leu Leu Asp Glu Leu Pro 
            260                 265                 270         


Gln Ser Val Leu Lys Trp Ala Pro Ser Gly Ser Ser Cys Cys Glu Ile 
        275                 280                 285             


Ala Gln Phe Leu Val Cys Ala His Ser Leu Ala Tyr Asp Glu Lys Pro 
    290                 295                 300                 


Asn Tyr Gln Ala Leu Lys Lys Ile Leu Asn Pro His Gly Ile Pro Leu 
305                 310                 315                 320 


Gly Pro Leu Asp Phe Ser Thr Lys Gly Gln Ser Ile Asn Val His Thr 
                325                 330                 335     


Pro Asn Ser Gln Lys Val Asp Ser Gln Lys Ala Ala Thr Lys Gln Val 
            340                 345                 350         


Asn Lys Ala His Asn Arg Leu Ile Glu Lys Lys Val His Ser Glu Arg 
        355                 360                 365             


Ser Ala Glu Ser Cys Ala Thr Trp Lys Val Gln Lys Glu Glu Lys Leu 
    370                 375                 380                 


Ile Gly Leu Met Asn Asn Glu Ala Ala Gln Glu Ser Thr Arg Arg Arg 
385                 390                 395                 400 


Gln Lys Tyr Gln Glu Ser Gln Glu Pro Leu Asn Glu Val Asn Ser Phe 
                405                 410                 415     


Pro Gln Lys Ile Ser Tyr Thr Gln Phe Pro Asn Ser Phe Tyr Glu Pro 
            420                 425                 430         


His Gln Asp Phe Thr Ser Pro Asp Ile Phe Lys Lys Ser Arg Ser Pro 
        435                 440                 445             


Ser Trp Tyr Lys Tyr Thr Ser Thr Val Ser Thr Gly Ile Thr Asp Leu 
    450                 455                 460                 


Glu Ser Ser Thr Gly Leu Trp Pro Thr Ile Ser Gln Phe Thr Leu Ser 
465                 470                 475                 480 


Glu Glu Thr Asn Ala Asp Val Tyr Tyr Tyr Arg Ile Ile Ile Pro Val 
                485                 490                 495     


Leu Leu Met Leu Val Phe Leu Ala Leu Phe Phe Leu 
            500                 505             


<210>  1428
<211>  485
<212>  PRT
<213>  Homo sapiens

<400>  1428

Met Glu Gly Asn Gln Trp Val Leu Gly Lys Lys Ile Gly Ser Gly Gly 
1               5                   10                  15      


Phe Gly Leu Ile Tyr Leu Ala Phe Pro Thr Asn Lys Pro Glu Lys Asp 
            20                  25                  30          


Ala Arg His Val Val Lys Val Glu Tyr Gln Glu Asn Gly Pro Leu Phe 
        35                  40                  45              


Ser Glu Leu Lys Phe Tyr Gln Arg Val Ala Lys Lys Asp Cys Ile Lys 
    50                  55                  60                  


Lys Trp Ile Glu Arg Lys Gln Leu Asp Tyr Leu Gly Ile Pro Leu Phe 
65                  70                  75                  80  


Tyr Gly Ser Gly Leu Thr Glu Phe Lys Gly Arg Ser Tyr Arg Phe Met 
                85                  90                  95      


Val Met Glu Arg Leu Gly Ile Asp Leu Gln Lys Ile Ser Gly Gln Asn 
            100                 105                 110         


Gly Thr Phe Lys Lys Ser Thr Val Leu Gln Leu Gly Ile Arg Met Leu 
        115                 120                 125             


Asp Val Leu Glu Tyr Ile His Glu Asn Glu Tyr Val His Gly Asp Ile 
    130                 135                 140                 


Lys Ala Ala Asn Leu Leu Leu Gly Tyr Lys Asn Pro Asp Gln Val Tyr 
145                 150                 155                 160 


Leu Ala Asp Tyr Gly Leu Ser Tyr Arg Tyr Cys Pro Asn Gly Asn His 
                165                 170                 175     


Lys Gln Tyr Gln Glu Asn Pro Arg Lys Gly His Asn Gly Thr Ile Glu 
            180                 185                 190         


Phe Thr Ser Leu Asp Ala His Lys Gly Val Ala Leu Ser Arg Arg Ser 
        195                 200                 205             


Asp Val Glu Ile Leu Gly Tyr Cys Met Leu Arg Trp Leu Cys Gly Lys 
    210                 215                 220                 


Leu Pro Trp Glu Gln Asn Leu Lys Asp Pro Val Ala Val Gln Thr Ala 
225                 230                 235                 240 


Lys Thr Asn Leu Leu Asp Glu Leu Pro Gln Ser Val Leu Lys Trp Ala 
                245                 250                 255     


Pro Ser Gly Ser Ser Cys Cys Glu Ile Ala Gln Phe Leu Val Cys Ala 
            260                 265                 270         


His Ser Leu Ala Tyr Asp Glu Lys Pro Asn Tyr Gln Ala Leu Lys Lys 
        275                 280                 285             


Ile Leu Asn Pro His Gly Ile Pro Leu Gly Pro Leu Asp Phe Ser Thr 
    290                 295                 300                 


Lys Gly Gln Ser Ile Asn Val His Thr Pro Asn Ser Gln Lys Val Asp 
305                 310                 315                 320 


Ser Gln Lys Ala Ala Thr Lys Gln Val Asn Lys Ala His Asn Arg Leu 
                325                 330                 335     


Ile Glu Lys Lys Val His Ser Glu Arg Ser Ala Glu Ser Cys Ala Thr 
            340                 345                 350         


Trp Lys Val Gln Lys Glu Glu Lys Leu Ile Gly Leu Met Asn Asn Glu 
        355                 360                 365             


Ala Ala Gln Glu Ser Thr Arg Arg Arg Gln Lys Tyr Gln Glu Ser Gln 
    370                 375                 380                 


Glu Pro Leu Asn Glu Val Asn Ser Phe Pro Gln Lys Ile Ser Tyr Thr 
385                 390                 395                 400 


Gln Phe Pro Asn Ser Phe Tyr Glu Pro His Gln Asp Phe Thr Ser Pro 
                405                 410                 415     


Asp Ile Phe Lys Lys Ser Arg Ser Pro Ser Trp Tyr Lys Tyr Thr Ser 
            420                 425                 430         


Thr Val Ser Thr Gly Ile Thr Asp Leu Glu Ser Ser Thr Gly Leu Trp 
        435                 440                 445             


Pro Thr Ile Ser Gln Phe Thr Leu Ser Glu Glu Thr Asn Ala Asp Val 
    450                 455                 460                 


Tyr Tyr Tyr Arg Ile Ile Ile Pro Val Leu Leu Met Leu Val Phe Leu 
465                 470                 475                 480 


Ala Leu Phe Phe Leu 
                485 


<210>  1429
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  1429

Met Pro Pro Lys Arg Asn Glu Lys Tyr Lys Leu Pro Ile Pro Phe Pro 
1               5                   10                  15      


Glu Gly Lys Val Leu Asp Asp Met Glu Gly Asn Gln Trp Val Leu Gly 
            20                  25                  30          


Lys Lys Ile Gly Ser Gly Gly Phe Gly Leu Ile Tyr Leu Ala Phe Pro 
        35                  40                  45              


Thr Asn Lys Pro Glu Lys Asp Ala Arg His Val Val Lys Val Glu Tyr 
    50                  55                  60                  


Gln Glu Asn Gly Pro Leu Phe Ser Glu Leu Lys Phe Tyr Gln Arg Val 
65                  70                  75                  80  


Ala Lys Lys Asp Cys Ile Lys Lys Trp Ile Glu Arg Lys Gln Leu Asp 
                85                  90                  95      


Tyr Leu Gly Ile Pro Leu Phe Tyr Gly Ser Gly Leu Thr Glu Phe Lys 
            100                 105                 110         


Gly Arg Ser Tyr Arg Phe Met Val Met Glu Arg Leu Gly Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Ser Gly Gln Asn Gly Thr Phe Lys Lys Ser Thr Val Leu 
    130                 135                 140                 


Gln Leu Gly Ile Arg Met Leu Asp Val Leu Glu Tyr Ile His Glu Asn 
145                 150                 155                 160 


Glu Tyr Val His Gly Asp Ile Lys Ala Ala Asn Leu Leu Leu Gly Tyr 
                165                 170                 175     


Lys Asn Pro Asp Gln Val Tyr Leu Ala Asp Tyr Gly Leu Ser Tyr Arg 
            180                 185                 190         


Tyr Cys Pro Asn Gly Asn His Lys Gln Tyr Gln Glu Asn Pro Arg Lys 
        195                 200                 205             


Gly His Asn Gly Thr Ile Glu Phe Thr Ser Leu Asp Ala His Lys Gly 
    210                 215                 220                 


Val Ala Leu Ser Arg Arg Ser Asp Val Glu Ile Leu Gly Tyr Cys Met 
225                 230                 235                 240 


Leu Arg Trp Leu Cys Gly Lys Leu Pro Trp Glu Gln Asn Leu Lys Asp 
                245                 250                 255     


Pro Val Ala Val Gln Thr Ala Lys Thr Asn Leu Leu Asp Glu Leu Pro 
            260                 265                 270         


Gln Ser Val Leu Lys Trp Ala Pro Ser Gly Ser Ser Cys Cys Glu Ile 
        275                 280                 285             


Ala Gln Phe Leu Val Cys Ala His Ser Leu Ala Tyr Asp Glu Lys Pro 
    290                 295                 300                 


Asn Tyr Gln Ala Leu Lys Lys Ile Leu Asn Pro His Gly Ile Pro Leu 
305                 310                 315                 320 


Gly Pro Leu Asp Phe Ser Thr Lys Gly Gln Ser Ile Asn Val His Thr 
                325                 330                 335     


Pro Asn Ser Gln Lys Val Asp Ser Gln Lys Ala Ala Thr Lys Gln Val 
            340                 345                 350         


Asn Lys Ala His Asn Arg Leu Ile Glu Lys Lys Val His Ser Glu Arg 
        355                 360                 365             


Ser Ala Glu Ser Cys Ala Thr Trp Lys Val Gln Lys Glu Glu Lys Leu 
    370                 375                 380                 


Ile Gly Leu Met Asn Asn Glu Ala Ala Gln Phe Arg 
385                 390                 395     


<210>  1430
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  1430

Met Lys Val Leu Gly His Arg Leu Glu Leu Leu Thr Gly Leu Leu Leu 
1               5                   10                  15      


His Asp Val Thr Met Ala Gly Leu Gln Glu Leu Arg Phe Pro Glu Glu 
            20                  25                  30          


Lys Pro Leu Leu Arg Gly Gln Asp Ala Thr Glu Leu Glu Ser Ser Asp 
        35                  40                  45              


Ala Phe Leu Leu Ala Ala Asp Thr Asp Trp Lys Glu His Asp Ile Glu 
    50                  55                  60                  


Thr Pro Tyr Gly Leu Leu His Val Val Ile Arg Gly Ser Pro Lys Gly 
65                  70                  75                  80  


Asn Arg Pro Ala Ile Leu Thr Tyr His Asp Val Gly Leu Asn His Lys 
                85                  90                  95      


Leu Cys Phe Asn Thr Phe Phe Asn Phe Glu Asp Met Gln Glu Ile Thr 
            100                 105                 110         


Lys His Phe Val Val Cys His Val Asp Ala Pro Gly Gln Gln Val Gly 
        115                 120                 125             


Ala Ser Gln Phe Pro Gln Gly Tyr Gln Phe Pro Ser Met Glu Gln Leu 
    130                 135                 140                 


Ala Ala Met Leu Pro Ser Val Val Gln His Phe Gly Phe Lys Tyr Val 
145                 150                 155                 160 


Ile Gly Ile Gly Val Gly Ala Gly Ala Tyr Val Leu Ala Lys Phe Ala 
                165                 170                 175     


Leu Ile Phe Pro Asp Leu Val Glu Gly Leu Val Leu Val Asn Ile Asp 
            180                 185                 190         


Pro Asn Gly Lys Gly Trp Ile Asp Trp Ala Ala Thr Lys Leu Ser Gly 
        195                 200                 205             


Leu Thr Ser Thr Leu Pro Asp Thr Val Leu Ser His Leu Phe Ser Gln 
    210                 215                 220                 


Glu Glu Leu Val Asn Asn Thr Glu Leu Val Gln Ser Tyr Arg Gln Gln 
225                 230                 235                 240 


Ile Gly Asn Val Val Asn Gln Ala Asn Leu Gln Leu Phe Trp Asn Met 
                245                 250                 255     


Tyr Asn Ser Arg Arg Asp Leu Asp Ile Asn Arg Pro Gly Thr Val Pro 
            260                 265                 270         


Asn Ala Lys Thr Leu Arg Cys Pro Val Met Leu Val Val Gly Asp Asn 
        275                 280                 285             


Ala Pro Ala Glu Asp Gly Val Val Glu Cys Asn Ser Lys Leu Asp Pro 
    290                 295                 300                 


Thr Thr Thr Thr Phe Leu Lys Met Ala Asp Ser Gly Gly Leu Pro Gln 
305                 310                 315                 320 


Val Thr Gln Pro Gly Lys Leu Thr Glu Ala Phe Lys Tyr Phe Leu Gln 
                325                 330                 335     


Gly Met Gly Tyr Met Pro Ser Ala Ser Met Thr Arg Leu Ala Arg Ser 
            340                 345                 350         


Arg Thr Ala Ser Leu Thr Ser Ala Ser Ser Val Asp Gly Ser Arg Pro 
        355                 360                 365             


Gln Ala Cys Thr His Ser Glu Ser Ser Glu Gly Leu Gly Gln Val Asn 
    370                 375                 380                 


His Thr Met Glu Val Ser Cys 
385                 390     


<210>  1431
<211>  532
<212>  PRT
<213>  Homo sapiens

<400>  1431

Met Met Met Val Arg Arg Gly Leu Leu Ala Trp Ile Ser Arg Val Val 
1               5                   10                  15      


Val Leu Leu Val Leu Leu Cys Cys Ala Ile Ser Val Leu Tyr Met Leu 
            20                  25                  30          


Ala Cys Thr Pro Lys Gly Asp Glu Glu Gln Leu Ala Leu Pro Arg Ala 
        35                  40                  45              


Asn Ser Pro Thr Gly Lys Glu Gly Tyr Gln Ala Val Leu Gln Glu Trp 
    50                  55                  60                  


Glu Glu Gln His Arg Asn Tyr Val Ser Ser Leu Lys Arg Gln Ile Ala 
65                  70                  75                  80  


Gln Leu Lys Glu Glu Leu Gln Glu Arg Ser Glu Gln Leu Arg Asn Gly 
                85                  90                  95      


Gln Tyr Gln Ala Ser Asp Ala Ala Gly Leu Gly Leu Asp Arg Ser Pro 
            100                 105                 110         


Pro Glu Lys Thr Gln Ala Asp Leu Leu Ala Phe Leu His Ser Gln Val 
        115                 120                 125             


Asp Lys Ala Glu Val Asn Ala Gly Val Lys Leu Ala Thr Glu Tyr Ala 
    130                 135                 140                 


Ala Val Pro Phe Asp Ser Phe Thr Leu Gln Lys Val Tyr Gln Leu Glu 
145                 150                 155                 160 


Thr Gly Leu Thr Arg His Pro Glu Glu Lys Pro Val Arg Lys Asp Lys 
                165                 170                 175     


Arg Asp Glu Leu Val Glu Ala Ile Glu Ser Ala Leu Glu Thr Leu Asn 
            180                 185                 190         


Ser Pro Ala Glu Asn Ser Pro Asn His Arg Pro Tyr Thr Ala Ser Asp 
        195                 200                 205             


Phe Ile Glu Gly Ile Tyr Arg Thr Glu Arg Asp Lys Gly Thr Leu Tyr 
    210                 215                 220                 


Glu Leu Thr Phe Lys Gly Asp His Lys His Glu Phe Lys Arg Leu Ile 
225                 230                 235                 240 


Leu Phe Arg Pro Phe Gly Pro Ile Met Lys Val Lys Asn Glu Lys Leu 
                245                 250                 255     


Asn Met Ala Asn Thr Leu Ile Asn Val Ile Val Pro Leu Ala Lys Arg 
            260                 265                 270         


Val Asp Lys Phe Arg Gln Phe Met Gln Asn Phe Arg Glu Met Cys Ile 
        275                 280                 285             


Glu Gln Asp Gly Arg Val His Leu Thr Val Val Tyr Phe Gly Lys Glu 
    290                 295                 300                 


Glu Ile Asn Glu Val Lys Gly Ile Leu Glu Asn Thr Ser Lys Ala Ala 
305                 310                 315                 320 


Asn Phe Arg Asn Phe Thr Phe Ile Gln Leu Asn Gly Glu Phe Ser Arg 
                325                 330                 335     


Gly Lys Gly Leu Asp Val Gly Ala Arg Phe Trp Lys Gly Ser Asn Val 
            340                 345                 350         


Leu Leu Phe Phe Cys Asp Val Asp Ile Tyr Phe Thr Ser Glu Phe Leu 
        355                 360                 365             


Asn Thr Cys Arg Leu Asn Thr Gln Pro Gly Lys Lys Val Phe Tyr Pro 
    370                 375                 380                 


Val Leu Phe Ser Gln Tyr Asn Pro Gly Ile Ile Tyr Gly His His Asp 
385                 390                 395                 400 


Ala Val Pro Pro Leu Glu Gln Gln Leu Val Ile Lys Lys Glu Thr Gly 
                405                 410                 415     


Phe Trp Arg Asp Phe Gly Phe Gly Met Thr Cys Gln Tyr Arg Ser Asp 
            420                 425                 430         


Phe Ile Asn Ile Gly Gly Phe Asp Leu Asp Ile Lys Gly Trp Gly Gly 
        435                 440                 445             


Glu Asp Val His Leu Tyr Arg Lys Tyr Leu His Ser Asn Leu Ile Val 
    450                 455                 460                 


Val Arg Thr Pro Val Arg Gly Leu Phe His Leu Trp His Glu Lys Arg 
465                 470                 475                 480 


Cys Met Asp Glu Leu Thr Pro Glu Gln Tyr Lys Met Cys Met Gln Ser 
                485                 490                 495     


Lys Ala Met Asn Glu Ala Ser His Gly Gln Leu Gly Met Leu Val Phe 
            500                 505                 510         


Arg His Glu Ile Glu Ala His Leu Arg Lys Gln Lys Gln Lys Thr Ser 
        515                 520                 525             


Ser Lys Lys Thr 
    530         


<210>  1432
<211>  1321
<212>  PRT
<213>  Homo sapiens

<400>  1432

Met Glu Leu Glu Asp Gly Val Val Tyr Gln Glu Glu Pro Gly Gly Ser 
1               5                   10                  15      


Gly Ala Val Met Ser Glu Arg Val Ser Gly Leu Ala Gly Ser Ile Tyr 
            20                  25                  30          


Arg Glu Phe Glu Arg Leu Ile Gly Arg Tyr Asp Glu Glu Val Val Lys 
        35                  40                  45              


Glu Leu Met Pro Leu Val Val Ala Val Leu Glu Asn Leu Asp Ser Val 
    50                  55                  60                  


Phe Ala Gln Asp Gln Glu His Gln Val Glu Leu Glu Leu Leu Arg Asp 
65                  70                  75                  80  


Asp Asn Glu Gln Leu Ile Thr Gln Tyr Glu Arg Glu Lys Ala Leu Arg 
                85                  90                  95      


Lys His Ala Glu Glu Lys Phe Ile Glu Phe Glu Asp Ser Gln Glu Gln 
            100                 105                 110         


Glu Lys Lys Asp Leu Gln Thr Arg Val Glu Ser Leu Glu Ser Gln Thr 
        115                 120                 125             


Arg Gln Leu Glu Leu Lys Ala Lys Asn Tyr Ala Asp Gln Ile Ser Arg 
    130                 135                 140                 


Leu Glu Glu Arg Glu Ala Glu Leu Lys Lys Glu Tyr Asn Ala Leu His 
145                 150                 155                 160 


Gln Arg His Thr Glu Met Ile His Asn Tyr Met Glu His Leu Glu Arg 
                165                 170                 175     


Thr Lys Leu His Gln Leu Ser Gly Ser Asp Gln Leu Glu Ser Thr Ala 
            180                 185                 190         


His Ser Arg Ile Arg Lys Glu Arg Pro Ile Ser Leu Gly Ile Phe Pro 
        195                 200                 205             


Leu Pro Ala Gly Asp Gly Leu Leu Thr Pro Asp Ala Gln Lys Gly Gly 
    210                 215                 220                 


Glu Thr Pro Gly Ser Glu Gln Trp Lys Phe Gln Glu Leu Ser Gln Pro 
225                 230                 235                 240 


Arg Ser His Thr Ser Leu Lys Val Ser Asn Ser Pro Glu Pro Gln Lys 
                245                 250                 255     


Ala Val Glu Gln Glu Asp Glu Leu Ser Asp Val Ser Gln Gly Gly Ser 
            260                 265                 270         


Lys Ala Thr Thr Pro Ala Ser Thr Ala Asn Ser Asp Val Ala Thr Ile 
        275                 280                 285             


Pro Thr Asp Thr Pro Leu Lys Glu Glu Asn Glu Gly Phe Val Lys Val 
    290                 295                 300                 


Thr Asp Ala Pro Asn Lys Ser Glu Ile Ser Lys His Ile Glu Val Gln 
305                 310                 315                 320 


Val Ala Gln Glu Thr Arg Asn Val Ser Thr Gly Ser Ala Glu Asn Glu 
                325                 330                 335     


Glu Lys Ser Glu Val Gln Ala Ile Ile Glu Ser Thr Pro Glu Leu Asp 
            340                 345                 350         


Met Asp Lys Asp Leu Ser Gly Tyr Lys Gly Ser Ser Thr Pro Thr Lys 
        355                 360                 365             


Gly Ile Glu Asn Lys Ala Phe Asp Arg Asn Thr Glu Ser Leu Phe Glu 
    370                 375                 380                 


Glu Leu Ser Ser Ala Gly Ser Gly Leu Ile Gly Asp Val Asp Glu Gly 
385                 390                 395                 400 


Ala Asp Leu Leu Gly Met Gly Arg Glu Val Glu Asn Leu Ile Leu Glu 
                405                 410                 415     


Asn Thr Gln Leu Leu Glu Thr Lys Asn Ala Leu Asn Ile Val Lys Asn 
            420                 425                 430         


Asp Leu Ile Ala Lys Val Asp Glu Leu Thr Cys Glu Lys Asp Val Leu 
        435                 440                 445             


Gln Gly Glu Leu Glu Ala Val Lys Gln Ala Lys Leu Lys Leu Glu Glu 
    450                 455                 460                 


Lys Asn Arg Glu Leu Glu Glu Glu Leu Arg Lys Ala Arg Ala Glu Ala 
465                 470                 475                 480 


Glu Asp Ala Arg Gln Lys Ala Lys Asp Asp Asp Asp Ser Asp Ile Pro 
                485                 490                 495     


Thr Ala Gln Arg Lys Arg Phe Thr Arg Val Glu Met Ala Arg Val Leu 
            500                 505                 510         


Met Glu Arg Asn Gln Tyr Lys Glu Arg Leu Met Glu Leu Gln Glu Ala 
        515                 520                 525             


Val Arg Trp Thr Glu Met Ile Arg Ala Ser Arg Glu Asn Pro Ala Met 
    530                 535                 540                 


Gln Glu Lys Lys Arg Ser Ser Ile Trp Gln Phe Phe Ser Arg Leu Phe 
545                 550                 555                 560 


Ser Ser Ser Ser Asn Thr Thr Lys Lys Pro Glu Pro Pro Val Asn Leu 
                565                 570                 575     


Lys Tyr Asn Ala Pro Thr Ser His Val Thr Pro Ser Val Lys Lys Arg 
            580                 585                 590         


Ser Ser Thr Leu Ser Gln Leu Pro Gly Asp Lys Ser Lys Ala Phe Asp 
        595                 600                 605             


Phe Leu Ser Glu Glu Thr Glu Ala Ser Leu Ala Ser Arg Arg Glu Gln 
    610                 615                 620                 


Lys Arg Glu Gln Tyr Arg Gln Val Lys Ala His Val Gln Lys Glu Asp 
625                 630                 635                 640 


Gly Arg Val Gln Ala Phe Gly Trp Ser Leu Pro Gln Lys Tyr Lys Gln 
                645                 650                 655     


Val Thr Asn Gly Gln Gly Glu Asn Lys Met Lys Asn Leu Pro Val Pro 
            660                 665                 670         


Val Tyr Leu Arg Pro Leu Asp Glu Lys Asp Thr Ser Met Lys Leu Trp 
        675                 680                 685             


Cys Ala Val Gly Val Asn Leu Ser Gly Gly Lys Thr Arg Asp Gly Gly 
    690                 695                 700                 


Ser Val Val Gly Ala Ser Val Phe Tyr Lys Asp Val Ala Gly Leu Asp 
705                 710                 715                 720 


Thr Glu Gly Ser Lys Gln Arg Ser Ala Ser Gln Ser Ser Leu Asp Lys 
                725                 730                 735     


Leu Asp Gln Glu Leu Lys Glu Gln Gln Lys Glu Leu Lys Asn Gln Glu 
            740                 745                 750         


Glu Leu Ser Ser Leu Val Trp Ile Cys Thr Ser Thr His Ser Ala Thr 
        755                 760                 765             


Lys Val Leu Ile Ile Asp Ala Val Gln Pro Gly Asn Ile Leu Asp Ser 
    770                 775                 780                 


Phe Thr Val Cys Asn Ser His Val Leu Cys Ile Ala Ser Val Pro Gly 
785                 790                 795                 800 


Ala Arg Glu Thr Asp Tyr Pro Ala Gly Glu Asp Leu Ser Glu Ser Gly 
                805                 810                 815     


Gln Val Asp Lys Ala Ser Leu Cys Gly Ser Met Thr Ser Asn Ser Ser 
            820                 825                 830         


Ala Glu Thr Asp Ser Leu Leu Gly Gly Ile Thr Val Val Gly Cys Ser 
        835                 840                 845             


Ala Glu Gly Val Thr Gly Ala Ala Thr Ser Pro Ser Thr Asn Gly Ala 
    850                 855                 860                 


Ser Pro Val Met Asp Lys Pro Pro Glu Met Glu Ala Glu Asn Ser Glu 
865                 870                 875                 880 


Val Asp Glu Asn Val Pro Thr Ala Glu Glu Ala Thr Glu Ala Thr Glu 
                885                 890                 895     


Gly Asn Ala Gly Ser Ala Glu Asp Thr Val Asp Ile Ser Gln Thr Gly 
            900                 905                 910         


Val Tyr Thr Glu His Val Phe Thr Asp Pro Leu Gly Val Gln Ile Pro 
        915                 920                 925             


Glu Asp Leu Ser Pro Val Tyr Gln Ser Ser Asn Asp Ser Asp Ala Tyr 
    930                 935                 940                 


Lys Asp Gln Ile Ser Val Leu Pro Asn Glu Gln Asp Leu Val Arg Glu 
945                 950                 955                 960 


Glu Ala Gln Lys Met Ser Ser Leu Leu Pro Thr Met Trp Leu Gly Ala 
                965                 970                 975     


Gln Asn Gly Cys Leu Tyr Val His Ser Ser Val Ala Gln Trp Arg Lys 
            980                 985                 990         


Cys Leu His Ser Ile Lys Leu Lys  Asp Ser Ile Leu Ser  Ile Val His 
        995                 1000                 1005             


Val Lys  Gly Ile Val Leu Val  Ala Leu Ala Asp Gly  Thr Leu Ala 
    1010                 1015                 1020             


Ile Phe  His Arg Gly Val Asp  Gly Gln Trp Asp Leu  Ser Asn Tyr 
    1025                 1030                 1035             


His Leu  Leu Asp Leu Gly Arg  Pro His His Ser Ile  Arg Cys Met 
    1040                 1045                 1050             


Thr Val  Val His Asp Lys Val  Trp Cys Gly Tyr Arg  Asn Lys Ile 
    1055                 1060                 1065             


Tyr Val  Val Gln Pro Lys Ala  Met Lys Ile Glu Lys  Ser Phe Asp 
    1070                 1075                 1080             


Ala His  Pro Arg Lys Glu Ser  Gln Val Arg Gln Leu  Ala Trp Val 
    1085                 1090                 1095             


Gly Asp  Gly Val Trp Val Ser  Ile Arg Leu Asp Ser  Thr Leu Arg 
    1100                 1105                 1110             


Leu Tyr  His Ala His Thr Tyr  Gln His Leu Gln Asp  Val Asp Ile 
    1115                 1120                 1125             


Glu Pro  Tyr Val Ser Lys Met  Leu Gly Thr Gly Lys  Leu Gly Phe 
    1130                 1135                 1140             


Ser Phe  Val Arg Ile Thr Ala  Leu Met Val Ser Cys  Asn Arg Leu 
    1145                 1150                 1155             


Trp Val  Gly Thr Gly Asn Gly  Val Ile Ile Ser Ile  Pro Leu Thr 
    1160                 1165                 1170             


Glu Thr  Asn Lys Thr Ser Gly  Val Pro Gly Asn Arg  Pro Gly Ser 
    1175                 1180                 1185             


Val Ile  Arg Val Tyr Gly Asp  Glu Asn Ser Asp Lys  Val Thr Pro 
    1190                 1195                 1200             


Gly Thr  Phe Ile Pro Tyr Cys  Ser Met Ala His Ala  Gln Leu Cys 
    1205                 1210                 1215             


Phe His  Gly His Arg Asp Ala  Val Lys Phe Phe Val  Ala Val Pro 
    1220                 1225                 1230             


Gly Gln  Val Ile Ser Pro Gln  Ser Ser Ser Ser Gly  Thr Asp Leu 
    1235                 1240                 1245             


Thr Gly  Asp Lys Ala Gly Pro  Ser Ala Gln Glu Pro  Gly Ser Gln 
    1250                 1255                 1260             


Thr Pro  Leu Lys Ser Met Leu  Val Ile Ser Gly Gly  Glu Gly Tyr 
    1265                 1270                 1275             


Ile Asp  Phe Arg Met Gly Asp  Glu Gly Gly Glu Ser  Glu Leu Leu 
    1280                 1285                 1290             


Gly Glu  Asp Leu Pro Leu Glu  Pro Ser Val Thr Lys  Ala Glu Arg 
    1295                 1300                 1305             


Ser His  Leu Ile Val Trp Gln  Val Met Tyr Gly Asn  Glu 
    1310                 1315                 1320     


<210>  1433
<211>  610
<212>  PRT
<213>  Homo sapiens

<400>  1433

Met His Phe Gln Ala Phe Trp Leu Cys Leu Gly Leu Leu Phe Ile Ser 
1               5                   10                  15      


Ile Asn Ala Glu Phe Met Asp Asp Asp Val Glu Thr Glu Asp Phe Glu 
            20                  25                  30          


Glu Asn Ser Glu Glu Ile Asp Val Asn Glu Ser Glu Leu Ser Ser Glu 
        35                  40                  45              


Ile Lys Tyr Lys Thr Pro Gln Pro Ile Gly Glu Val Tyr Phe Ala Glu 
    50                  55                  60                  


Thr Phe Asp Ser Gly Arg Leu Ala Gly Trp Val Leu Ser Lys Ala Lys 
65                  70                  75                  80  


Lys Asp Asp Met Asp Glu Glu Ile Ser Ile Tyr Asp Gly Arg Trp Glu 
                85                  90                  95      


Ile Glu Glu Leu Lys Glu Asn Gln Val Pro Gly Asp Arg Gly Leu Val 
            100                 105                 110         


Leu Lys Ser Arg Ala Lys His His Ala Ile Ser Ala Val Leu Ala Lys 
        115                 120                 125             


Pro Phe Ile Phe Ala Asp Lys Pro Leu Ile Val Gln Tyr Glu Val Asn 
    130                 135                 140                 


Phe Gln Asp Gly Ile Asp Cys Gly Gly Ala Tyr Ile Lys Leu Leu Ala 
145                 150                 155                 160 


Asp Thr Asp Asp Leu Ile Leu Glu Asn Phe Tyr Asp Lys Thr Ser Tyr 
                165                 170                 175     


Ile Ile Met Phe Gly Pro Asp Lys Cys Gly Glu Asp Tyr Lys Leu His 
            180                 185                 190         


Phe Ile Phe Arg His Lys His Pro Lys Thr Gly Val Phe Glu Glu Lys 
        195                 200                 205             


His Ala Lys Pro Pro Asp Val Asp Leu Lys Lys Phe Phe Thr Asp Arg 
    210                 215                 220                 


Lys Thr His Leu Tyr Thr Leu Val Met Asn Pro Asp Asp Thr Phe Glu 
225                 230                 235                 240 


Val Leu Val Asp Gln Thr Val Val Asn Lys Gly Ser Leu Leu Glu Asp 
                245                 250                 255     


Val Val Pro Pro Ile Lys Pro Pro Lys Glu Ile Glu Asp Pro Asn Asp 
            260                 265                 270         


Lys Lys Pro Glu Glu Trp Asp Glu Arg Ala Lys Ile Pro Asp Pro Ser 
        275                 280                 285             


Ala Val Lys Pro Glu Asp Trp Asp Glu Ser Glu Pro Ala Gln Ile Glu 
    290                 295                 300                 


Asp Ser Ser Val Val Lys Pro Ala Gly Trp Leu Asp Asp Glu Pro Lys 
305                 310                 315                 320 


Phe Ile Pro Asp Pro Asn Ala Glu Lys Pro Asp Asp Trp Asn Glu Asp 
                325                 330                 335     


Thr Asp Gly Glu Trp Glu Ala Pro Gln Ile Leu Asn Pro Ala Cys Arg 
            340                 345                 350         


Ile Gly Cys Gly Glu Trp Lys Pro Pro Met Ile Asp Asn Pro Lys Tyr 
        355                 360                 365             


Lys Gly Val Trp Arg Pro Pro Leu Val Asp Asn Pro Asn Tyr Gln Gly 
    370                 375                 380                 


Ile Trp Ser Pro Arg Lys Ile Pro Asn Pro Asp Tyr Phe Glu Asp Asp 
385                 390                 395                 400 


His Pro Phe Leu Leu Thr Ser Phe Ser Ala Leu Gly Leu Glu Leu Trp 
                405                 410                 415     


Ser Met Thr Ser Asp Ile Tyr Phe Asp Asn Phe Ile Ile Cys Ser Glu 
            420                 425                 430         


Lys Glu Val Ala Asp His Trp Ala Ala Asp Gly Trp Arg Trp Lys Ile 
        435                 440                 445             


Met Ile Ala Asn Ala Asn Lys Pro Gly Val Leu Lys Gln Leu Met Ala 
    450                 455                 460                 


Ala Ala Glu Gly His Pro Trp Leu Trp Leu Ile Tyr Leu Val Thr Ala 
465                 470                 475                 480 


Gly Val Pro Ile Ala Leu Ile Thr Ser Phe Cys Trp Pro Arg Lys Val 
                485                 490                 495     


Lys Lys Lys His Lys Asp Thr Glu Tyr Lys Lys Thr Asp Ile Cys Ile 
            500                 505                 510         


Pro Gln Thr Lys Gly Val Leu Glu Gln Glu Glu Lys Glu Glu Lys Ala 
        515                 520                 525             


Ala Leu Glu Lys Pro Met Asp Leu Glu Glu Glu Lys Lys Gln Asn Asp 
    530                 535                 540                 


Gly Glu Met Leu Glu Lys Glu Glu Glu Ser Glu Pro Glu Glu Lys Ser 
545                 550                 555                 560 


Glu Glu Glu Ile Glu Ile Ile Glu Gly Gln Glu Glu Ser Asn Gln Ser 
                565                 570                 575     


Asn Lys Ser Gly Ser Glu Asp Glu Met Lys Glu Ala Asp Glu Ser Thr 
            580                 585                 590         


Gly Ser Gly Asp Gly Pro Ile Lys Ser Val Arg Lys Arg Arg Val Arg 
        595                 600                 605             


Lys Asp 
    610 


<210>  1434
<211>  921
<212>  PRT
<213>  Homo sapiens

<400>  1434

Met Ser Thr Lys Val Arg Lys Cys Lys Glu Gln Ala Arg Val Thr Phe 
1               5                   10                  15      


Pro Ala Pro Glu Glu Glu Glu Asp Glu Gly Glu Asp Glu Gly Ala Glu 
            20                  25                  30          


Pro Gln Arg Arg Arg Arg Gly Trp Arg Gly Val Asn Gly Gly Leu Glu 
        35                  40                  45              


Pro Arg Ser Ala Pro Ser Gln Arg Glu Pro His Gly Tyr Cys Pro Pro 
    50                  55                  60                  


Pro Phe Ser His Gly Pro Asp Leu Ser Met Glu Gly Ser Pro Ser Leu 
65                  70                  75                  80  


Arg Arg Met Thr Val Met Arg Glu Lys Gly Arg Arg Gln Ala Val Arg 
                85                  90                  95      


Gly Pro Ala Phe Met Phe Asn Asp Arg Gly Thr Ser Leu Thr Ala Glu 
            100                 105                 110         


Glu Glu Arg Phe Leu Asp Ala Ala Glu Tyr Gly Asn Ile Pro Val Val 
        115                 120                 125             


Arg Lys Met Leu Glu Glu Ser Lys Thr Leu Asn Val Asn Cys Val Asp 
    130                 135                 140                 


Tyr Met Gly Gln Asn Ala Leu Gln Leu Ala Val Gly Asn Glu His Leu 
145                 150                 155                 160 


Glu Val Thr Glu Leu Leu Leu Lys Lys Glu Asn Leu Ala Arg Ile Gly 
                165                 170                 175     


Asp Ala Leu Leu Leu Ala Ile Ser Lys Gly Tyr Val Arg Ile Val Glu 
            180                 185                 190         


Ala Ile Leu Asn His Pro Gly Phe Ala Ala Ser Lys Arg Leu Thr Leu 
        195                 200                 205             


Ser Pro Cys Glu Gln Glu Leu Gln Asp Asp Asp Phe Tyr Ala Tyr Asp 
    210                 215                 220                 


Glu Asp Gly Thr Arg Phe Ser Pro Asp Ile Thr Pro Ile Ile Leu Ala 
225                 230                 235                 240 


Ala His Cys Gln Lys Tyr Glu Val Val His Met Leu Leu Met Lys Gly 
                245                 250                 255     


Ala Arg Ile Glu Arg Pro His Asp Tyr Phe Cys Lys Cys Gly Asp Cys 
            260                 265                 270         


Met Glu Lys Gln Arg His Asp Ser Phe Ser His Ser Arg Ser Arg Ile 
        275                 280                 285             


Asn Ala Tyr Lys Gly Leu Ala Ser Pro Ala Tyr Leu Ser Leu Ser Ser 
    290                 295                 300                 


Glu Asp Pro Val Leu Thr Ala Leu Glu Leu Ser Asn Glu Leu Ala Lys 
305                 310                 315                 320 


Leu Ala Asn Ile Glu Lys Glu Phe Lys Asn Asp Tyr Arg Lys Leu Ser 
                325                 330                 335     


Met Gln Cys Lys Asp Phe Val Val Gly Val Leu Asp Leu Cys Arg Asp 
            340                 345                 350         


Ser Glu Glu Val Glu Ala Ile Leu Asn Gly Asp Leu Glu Ser Ala Glu 
        355                 360                 365             


Pro Leu Glu Val His Arg His Lys Ala Ser Leu Ser Arg Val Lys Leu 
    370                 375                 380                 


Ala Ile Lys Tyr Glu Val Lys Lys Phe Val Ala His Pro Asn Cys Gln 
385                 390                 395                 400 


Gln Gln Leu Leu Thr Ile Trp Tyr Glu Asn Leu Ser Gly Leu Arg Glu 
                405                 410                 415     


Gln Thr Ile Ala Ile Lys Cys Leu Val Val Leu Val Val Ala Leu Gly 
            420                 425                 430         


Leu Pro Phe Leu Ala Ile Gly Tyr Trp Ile Ala Pro Cys Ser Arg Leu 
        435                 440                 445             


Gly Lys Ile Leu Arg Ser Pro Phe Met Lys Phe Val Ala His Ala Ala 
    450                 455                 460                 


Ser Phe Ile Ile Phe Leu Gly Leu Leu Val Phe Asn Ala Ser Asp Arg 
465                 470                 475                 480 


Phe Glu Gly Ile Thr Thr Leu Pro Asn Ile Thr Val Thr Asp Tyr Pro 
                485                 490                 495     


Lys Gln Ile Phe Arg Val Lys Thr Thr Gln Phe Thr Trp Thr Glu Met 
            500                 505                 510         


Leu Ile Met Val Trp Val Leu Gly Met Met Trp Ser Glu Cys Lys Glu 
        515                 520                 525             


Leu Trp Leu Glu Gly Pro Arg Glu Tyr Ile Leu Gln Leu Trp Asn Val 
    530                 535                 540                 


Leu Asp Phe Gly Met Leu Ser Ile Phe Ile Ala Ala Phe Thr Ala Arg 
545                 550                 555                 560 


Phe Leu Ala Phe Leu Gln Ala Thr Lys Ala Gln Gln Tyr Val Asp Ser 
                565                 570                 575     


Tyr Val Gln Glu Ser Asp Leu Ser Glu Val Thr Leu Pro Pro Glu Ile 
            580                 585                 590         


Gln Tyr Phe Thr Tyr Ala Arg Asp Lys Trp Leu Pro Ser Asp Pro Gln 
        595                 600                 605             


Ile Ile Ser Glu Gly Leu Tyr Ala Ile Ala Val Val Leu Ser Phe Ser 
    610                 615                 620                 


Arg Ile Ala Tyr Ile Leu Pro Ala Asn Glu Ser Phe Gly Pro Leu Gln 
625                 630                 635                 640 


Ile Ser Leu Gly Arg Thr Val Lys Asp Ile Phe Lys Phe Met Val Leu 
                645                 650                 655     


Phe Ile Met Val Phe Phe Ala Phe Met Ile Gly Met Phe Ile Leu Tyr 
            660                 665                 670         


Ser Tyr Tyr Leu Gly Ala Lys Val Asn Ala Ala Phe Thr Thr Val Glu 
        675                 680                 685             


Glu Ser Phe Lys Thr Leu Phe Trp Ser Ile Phe Gly Leu Ser Glu Val 
    690                 695                 700                 


Thr Ser Val Val Leu Lys Tyr Asp His Lys Phe Ile Glu Asn Ile Gly 
705                 710                 715                 720 


Tyr Val Leu Tyr Gly Ile Tyr Asn Val Thr Met Val Val Val Leu Leu 
                725                 730                 735     


Asn Met Leu Ile Ala Met Ile Asn Ser Ser Tyr Gln Glu Ile Glu Asp 
            740                 745                 750         


Asp Ser Asp Val Glu Trp Lys Phe Ala Arg Ser Lys Leu Trp Leu Ser 
        755                 760                 765             


Tyr Phe Asp Asp Gly Lys Thr Leu Pro Pro Pro Phe Ser Leu Val Pro 
    770                 775                 780                 


Ser Pro Lys Ser Phe Val Tyr Phe Ile Met Arg Ile Val Asn Phe Pro 
785                 790                 795                 800 


Lys Cys Arg Arg Arg Arg Leu Gln Lys Asp Ile Glu Met Gly Met Gly 
                805                 810                 815     


Asn Ser Lys Ser Arg Leu Asn Leu Phe Thr Gln Ser Asn Ser Arg Val 
            820                 825                 830         


Phe Glu Ser His Ser Phe Asn Ser Ile Leu Asn Gln Pro Thr Arg Tyr 
        835                 840                 845             


Gln Gln Ile Met Lys Arg Leu Ile Lys Arg Tyr Val Leu Lys Ala Gln 
    850                 855                 860                 


Val Asp Lys Glu Asn Asp Glu Val Asn Glu Gly Glu Leu Lys Glu Ile 
865                 870                 875                 880 


Lys Gln Asp Ile Ser Ser Leu Arg Tyr Glu Leu Leu Glu Asp Lys Ser 
                885                 890                 895     


Gln Ala Thr Glu Glu Leu Ala Ile Leu Ile His Lys Leu Ser Glu Lys 
            900                 905                 910         


Leu Asn Pro Ser Met Leu Arg Cys Glu 
        915                 920     


<210>  1435
<211>  820
<212>  PRT
<213>  Homo sapiens

<400>  1435

Met Lys Met Leu Leu Leu Leu His Cys Leu Gly Val Phe Leu Ser Cys 
1               5                   10                  15      


Ser Gly His Ile Gln Asp Glu His Pro Gln Tyr His Ser Pro Pro Asp 
            20                  25                  30          


Val Val Ile Pro Val Arg Ile Thr Gly Thr Thr Arg Gly Met Thr Pro 
        35                  40                  45              


Pro Gly Trp Leu Ser Tyr Ile Leu Pro Phe Gly Gly Gln Lys His Ile 
    50                  55                  60                  


Ile His Ile Lys Val Lys Lys Leu Leu Phe Ser Lys His Leu Pro Val 
65                  70                  75                  80  


Phe Thr Tyr Thr Asp Gln Gly Ala Ile Leu Glu Asp Gln Pro Phe Val 
                85                  90                  95      


Gln Asn Asn Cys Tyr Tyr His Gly Tyr Val Glu Gly Asp Pro Glu Ser 
            100                 105                 110         


Leu Val Ser Leu Ser Thr Cys Phe Gly Gly Phe Gln Gly Ile Leu Gln 
        115                 120                 125             


Ile Asn Asp Phe Ala Tyr Glu Ile Lys Pro Leu Ala Phe Ser Thr Thr 
    130                 135                 140                 


Phe Glu His Leu Val Tyr Lys Met Asp Ser Glu Glu Lys Gln Phe Ser 
145                 150                 155                 160 


Thr Met Arg Ser Gly Phe Met Gln Asn Glu Ile Thr Cys Arg Met Glu 
                165                 170                 175     


Phe Glu Glu Ile Asp Asn Ser Thr Gln Lys Gln Ser Ser Tyr Val Gly 
            180                 185                 190         


Trp Trp Ile His Phe Arg Ile Val Glu Ile Val Val Val Ile Asp Asn 
        195                 200                 205             


Tyr Leu Tyr Ile Arg Tyr Glu Arg Asn Asp Ser Lys Leu Leu Glu Asp 
    210                 215                 220                 


Leu Tyr Val Ile Val Asn Ile Val Asp Ser Ile Leu Asp Val Ile Gly 
225                 230                 235                 240 


Val Lys Val Leu Leu Phe Gly Leu Glu Ile Trp Thr Asn Lys Asn Leu 
                245                 250                 255     


Ile Val Val Asp Asp Val Arg Lys Ser Val His Leu Tyr Cys Lys Trp 
            260                 265                 270         


Lys Ser Glu Asn Ile Thr Pro Arg Met Gln His Asp Thr Ser His Leu 
        275                 280                 285             


Phe Thr Thr Leu Gly Leu Arg Gly Leu Ser Gly Ile Gly Ala Phe Arg 
    290                 295                 300                 


Gly Met Cys Thr Pro His Arg Ser Cys Ala Ile Val Thr Phe Met Asn 
305                 310                 315                 320 


Lys Thr Leu Gly Thr Phe Ser Ile Ala Val Ala His His Leu Gly His 
                325                 330                 335     


Asn Leu Gly Met Asn His Asp Glu Asp Thr Cys Arg Cys Ser Gln Pro 
            340                 345                 350         


Arg Cys Ile Met His Glu Gly Asn Pro Pro Ile Thr Lys Phe Ser Asn 
        355                 360                 365             


Cys Ser Tyr Gly Asp Phe Trp Glu Tyr Thr Val Glu Arg Thr Lys Cys 
    370                 375                 380                 


Leu Leu Glu Thr Val His Thr Lys Asp Ile Phe Asn Val Lys Arg Cys 
385                 390                 395                 400 


Gly Asn Gly Val Val Glu Glu Gly Glu Glu Cys Asp Cys Gly Pro Leu 
                405                 410                 415     


Lys His Cys Ala Lys Asp Pro Cys Cys Leu Ser Asn Cys Thr Leu Thr 
            420                 425                 430         


Asp Gly Ser Thr Cys Ala Phe Gly Leu Cys Cys Lys Asp Cys Lys Phe 
        435                 440                 445             


Leu Pro Ser Gly Lys Val Cys Arg Lys Glu Val Asn Glu Cys Asp Leu 
    450                 455                 460                 


Pro Glu Trp Cys Asn Gly Thr Ser His Lys Cys Pro Asp Asp Phe Tyr 
465                 470                 475                 480 


Val Glu Asp Gly Ile Pro Cys Lys Glu Arg Gly Tyr Cys Tyr Glu Lys 
                485                 490                 495     


Ser Cys His Asp Arg Asn Glu Gln Cys Arg Arg Ile Phe Gly Ala Gly 
            500                 505                 510         


Ala Asn Thr Ala Ser Glu Thr Cys Tyr Lys Glu Leu Asn Thr Leu Gly 
        515                 520                 525             


Asp Arg Val Gly His Cys Gly Ile Lys Asn Ala Thr Tyr Ile Lys Cys 
    530                 535                 540                 


Asn Ile Ser Asp Val Gln Cys Gly Arg Ile Gln Cys Glu Asn Val Thr 
545                 550                 555                 560 


Glu Ile Pro Asn Met Ser Asp His Thr Thr Val His Trp Ala Arg Phe 
                565                 570                 575     


Asn Asp Ile Met Cys Trp Ser Thr Asp Tyr His Leu Gly Met Lys Gly 
            580                 585                 590         


Pro Asp Ile Gly Glu Val Lys Asp Gly Thr Glu Cys Gly Ile Asp His 
        595                 600                 605             


Ile Cys Ile His Arg His Cys Val His Ile Thr Ile Leu Asn Ser Asn 
    610                 615                 620                 


Cys Ser Pro Ala Phe Cys Asn Lys Arg Gly Ile Cys Asn Asn Lys His 
625                 630                 635                 640 


His Cys His Cys Asn Tyr Leu Trp Asp Pro Pro Asn Cys Leu Ile Lys 
                645                 650                 655     


Gly Tyr Gly Gly Ser Val Asp Ser Gly Pro Pro Pro Lys Arg Lys Lys 
            660                 665                 670         


Lys Lys Lys Phe Cys Tyr Leu Cys Ile Leu Leu Leu Ile Val Leu Phe 
        675                 680                 685             


Ile Leu Leu Cys Cys Leu Tyr Arg Leu Cys Lys Lys Ser Lys Pro Ile 
    690                 695                 700                 


Lys Lys Gln Gln Asp Val Gln Thr Pro Ser Ala Lys Glu Glu Glu Lys 
705                 710                 715                 720 


Ile Gln Arg Arg Pro His Glu Leu Pro Pro Gln Ser Gln Pro Trp Val 
                725                 730                 735     


Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser His Pro 
            740                 745                 750         


Gln Val Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser 
        755                 760                 765             


Gln Pro Arg Val Met Pro Ser Gln Ser Gln Pro Pro Val Met Pro Ser 
    770                 775                 780                 


Gln Ser His Pro Gln Leu Thr Pro Ser Gln Ser Gln Pro Pro Val Thr 
785                 790                 795                 800 


Pro Ser Gln Arg Gln Pro Gln Leu Met Pro Ser Gln Ser Gln Pro Pro 
                805                 810                 815     


Val Thr Pro Ser 
            820 


<210>  1436
<211>  820
<212>  PRT
<213>  Homo sapiens

<400>  1436

Met Lys Met Leu Leu Leu Leu His Cys Leu Gly Val Phe Leu Ser Cys 
1               5                   10                  15      


Ser Gly His Ile Gln Asp Glu His Pro Gln Tyr His Ser Pro Pro Asp 
            20                  25                  30          


Val Val Ile Pro Val Arg Ile Thr Gly Thr Thr Arg Gly Met Thr Pro 
        35                  40                  45              


Pro Gly Trp Leu Ser Tyr Ile Leu Pro Phe Gly Gly Gln Lys His Ile 
    50                  55                  60                  


Ile His Ile Lys Val Lys Lys Leu Leu Phe Ser Lys His Leu Pro Val 
65                  70                  75                  80  


Phe Thr Tyr Thr Asp Gln Gly Ala Ile Leu Glu Asp Gln Pro Phe Val 
                85                  90                  95      


Gln Asn Asn Cys Tyr Tyr His Gly Tyr Val Glu Gly Asp Pro Glu Ser 
            100                 105                 110         


Leu Val Ser Leu Ser Thr Cys Phe Gly Gly Phe Gln Gly Ile Leu Gln 
        115                 120                 125             


Ile Asn Asp Phe Ala Tyr Glu Ile Lys Pro Leu Ala Phe Ser Thr Thr 
    130                 135                 140                 


Phe Glu His Leu Val Tyr Lys Met Asp Ser Glu Glu Lys Gln Phe Ser 
145                 150                 155                 160 


Thr Met Arg Ser Gly Phe Met Gln Asn Glu Ile Thr Cys Arg Met Glu 
                165                 170                 175     


Phe Glu Glu Ile Asp Asn Ser Thr Gln Lys Gln Ser Ser Tyr Val Gly 
            180                 185                 190         


Trp Trp Ile His Phe Arg Ile Val Glu Ile Val Val Val Ile Asp Asn 
        195                 200                 205             


Tyr Leu Tyr Ile Arg Tyr Glu Arg Asn Asp Ser Lys Leu Leu Glu Asp 
    210                 215                 220                 


Leu Tyr Val Ile Val Asn Ile Val Asp Ser Ile Leu Asp Val Ile Gly 
225                 230                 235                 240 


Val Lys Val Leu Leu Phe Gly Leu Glu Ile Trp Thr Asn Lys Asn Leu 
                245                 250                 255     


Ile Val Val Asp Asp Val Arg Lys Ser Val His Leu Tyr Cys Lys Trp 
            260                 265                 270         


Lys Ser Glu Asn Ile Thr Pro Arg Met Gln His Asp Thr Ser His Leu 
        275                 280                 285             


Phe Thr Thr Leu Gly Leu Arg Gly Leu Ser Gly Ile Gly Ala Phe Arg 
    290                 295                 300                 


Gly Met Cys Thr Pro His Arg Ser Cys Ala Ile Val Thr Phe Met Asn 
305                 310                 315                 320 


Lys Thr Leu Gly Thr Phe Ser Ile Ala Val Ala His His Leu Gly His 
                325                 330                 335     


Asn Leu Gly Met Asn His Asp Glu Asp Thr Cys Arg Cys Ser Gln Pro 
            340                 345                 350         


Arg Cys Ile Met His Glu Gly Asn Pro Pro Ile Thr Lys Phe Ser Asn 
        355                 360                 365             


Cys Ser Tyr Gly Asp Phe Trp Glu Tyr Thr Val Glu Arg Thr Lys Cys 
    370                 375                 380                 


Leu Leu Glu Thr Val His Thr Lys Asp Ile Phe Asn Val Lys Arg Cys 
385                 390                 395                 400 


Gly Asn Gly Val Val Glu Glu Gly Glu Glu Cys Asp Cys Gly Pro Leu 
                405                 410                 415     


Lys His Cys Ala Lys Asp Pro Cys Cys Leu Ser Asn Cys Thr Leu Thr 
            420                 425                 430         


Asp Gly Ser Thr Cys Ala Phe Gly Leu Cys Cys Lys Asp Cys Lys Phe 
        435                 440                 445             


Leu Pro Ser Gly Lys Val Cys Arg Lys Glu Val Asn Glu Cys Asp Leu 
    450                 455                 460                 


Pro Glu Trp Cys Asn Gly Thr Ser His Lys Cys Pro Asp Asp Phe Tyr 
465                 470                 475                 480 


Val Glu Asp Gly Ile Pro Cys Lys Glu Arg Gly Tyr Cys Tyr Glu Lys 
                485                 490                 495     


Ser Cys His Asp Arg Asn Glu Gln Cys Arg Arg Ile Phe Gly Ala Gly 
            500                 505                 510         


Ala Asn Thr Ala Ser Glu Thr Cys Tyr Lys Glu Leu Asn Thr Leu Gly 
        515                 520                 525             


Asp Arg Val Gly His Cys Gly Ile Lys Asn Ala Thr Tyr Ile Lys Cys 
    530                 535                 540                 


Asn Ile Ser Asp Val Gln Cys Gly Arg Ile Gln Cys Glu Asn Val Thr 
545                 550                 555                 560 


Glu Ile Pro Asn Met Ser Asp His Thr Thr Val His Trp Ala Arg Phe 
                565                 570                 575     


Asn Asp Ile Met Cys Trp Ser Thr Asp Tyr His Leu Gly Met Lys Gly 
            580                 585                 590         


Pro Asp Ile Gly Glu Val Lys Asp Gly Thr Glu Cys Gly Ile Asp His 
        595                 600                 605             


Ile Cys Ile His Arg His Cys Val His Ile Thr Ile Leu Asn Ser Asn 
    610                 615                 620                 


Cys Ser Pro Ala Phe Cys Asn Lys Arg Gly Ile Cys Asn Asn Lys His 
625                 630                 635                 640 


His Cys His Cys Asn Tyr Leu Trp Asp Pro Pro Asn Cys Leu Ile Lys 
                645                 650                 655     


Gly Tyr Gly Gly Ser Val Asp Ser Gly Pro Pro Pro Lys Arg Lys Lys 
            660                 665                 670         


Lys Lys Lys Phe Cys Tyr Leu Cys Ile Leu Leu Leu Ile Val Leu Phe 
        675                 680                 685             


Ile Leu Leu Cys Cys Leu Tyr Arg Leu Cys Lys Lys Ser Lys Pro Ile 
    690                 695                 700                 


Lys Lys Gln Gln Asp Val Gln Thr Pro Ser Ala Lys Glu Glu Glu Lys 
705                 710                 715                 720 


Ile Gln Arg Arg Pro His Glu Leu Pro Pro Gln Ser Gln Pro Trp Val 
                725                 730                 735     


Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser His Pro 
            740                 745                 750         


Gln Val Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser 
        755                 760                 765             


Gln Pro Arg Val Met Pro Ser Gln Ser Gln Pro Pro Val Met Pro Ser 
    770                 775                 780                 


Gln Ser His Pro Gln Leu Thr Pro Ser Gln Ser Gln Pro Pro Val Thr 
785                 790                 795                 800 


Pro Ser Gln Arg Gln Pro Gln Leu Met Pro Ser Gln Ser Gln Pro Pro 
                805                 810                 815     


Val Thr Pro Ser 
            820 


<210>  1437
<211>  820
<212>  PRT
<213>  Homo sapiens

<400>  1437

Met Lys Met Leu Leu Leu Leu His Cys Leu Gly Val Phe Leu Ser Cys 
1               5                   10                  15      


Ser Gly His Ile Gln Asp Glu His Pro Gln Tyr His Ser Pro Pro Asp 
            20                  25                  30          


Val Val Ile Pro Val Arg Ile Thr Gly Thr Thr Arg Gly Met Thr Pro 
        35                  40                  45              


Pro Gly Trp Leu Ser Tyr Ile Leu Pro Phe Gly Gly Gln Lys His Ile 
    50                  55                  60                  


Ile His Ile Lys Val Lys Lys Leu Leu Phe Ser Lys His Leu Pro Val 
65                  70                  75                  80  


Phe Thr Tyr Thr Asp Gln Gly Ala Ile Leu Glu Asp Gln Pro Phe Val 
                85                  90                  95      


Gln Asn Asn Cys Tyr Tyr His Gly Tyr Val Glu Gly Asp Pro Glu Ser 
            100                 105                 110         


Leu Val Ser Leu Ser Thr Cys Phe Gly Gly Phe Gln Gly Ile Leu Gln 
        115                 120                 125             


Ile Asn Asp Phe Ala Tyr Glu Ile Lys Pro Leu Ala Phe Ser Thr Thr 
    130                 135                 140                 


Phe Glu His Leu Val Tyr Lys Met Asp Ser Glu Glu Lys Gln Phe Ser 
145                 150                 155                 160 


Thr Met Arg Ser Gly Phe Met Gln Asn Glu Ile Thr Cys Arg Met Glu 
                165                 170                 175     


Phe Glu Glu Ile Asp Asn Ser Thr Gln Lys Gln Ser Ser Tyr Val Gly 
            180                 185                 190         


Trp Trp Ile His Phe Arg Ile Val Glu Ile Val Val Val Ile Asp Asn 
        195                 200                 205             


Tyr Leu Tyr Ile Arg Tyr Glu Arg Asn Asp Ser Lys Leu Leu Glu Asp 
    210                 215                 220                 


Leu Tyr Val Ile Val Asn Ile Val Asp Ser Ile Leu Asp Val Ile Gly 
225                 230                 235                 240 


Val Lys Val Leu Leu Phe Gly Leu Glu Ile Trp Thr Asn Lys Asn Leu 
                245                 250                 255     


Ile Val Val Asp Asp Val Arg Lys Ser Val His Leu Tyr Cys Lys Trp 
            260                 265                 270         


Lys Ser Glu Asn Ile Thr Pro Arg Met Gln His Asp Thr Ser His Leu 
        275                 280                 285             


Phe Thr Thr Leu Gly Leu Arg Gly Leu Ser Gly Ile Gly Ala Phe Arg 
    290                 295                 300                 


Gly Met Cys Thr Pro His Arg Ser Cys Ala Ile Val Thr Phe Met Asn 
305                 310                 315                 320 


Lys Thr Leu Gly Thr Phe Ser Ile Ala Val Ala His His Leu Gly His 
                325                 330                 335     


Asn Leu Gly Met Asn His Asp Glu Asp Thr Cys Arg Cys Ser Gln Pro 
            340                 345                 350         


Arg Cys Ile Met His Glu Gly Asn Pro Pro Ile Thr Lys Phe Ser Asn 
        355                 360                 365             


Cys Ser Tyr Gly Asp Phe Trp Glu Tyr Thr Val Glu Arg Thr Lys Cys 
    370                 375                 380                 


Leu Leu Glu Thr Val His Thr Lys Asp Ile Phe Asn Val Lys Arg Cys 
385                 390                 395                 400 


Gly Asn Gly Val Val Glu Glu Gly Glu Glu Cys Asp Cys Gly Pro Leu 
                405                 410                 415     


Lys His Cys Ala Lys Asp Pro Cys Cys Leu Ser Asn Cys Thr Leu Thr 
            420                 425                 430         


Asp Gly Ser Thr Cys Ala Phe Gly Leu Cys Cys Lys Asp Cys Lys Phe 
        435                 440                 445             


Leu Pro Ser Gly Lys Val Cys Arg Lys Glu Val Asn Glu Cys Asp Leu 
    450                 455                 460                 


Pro Glu Trp Cys Asn Gly Thr Ser His Lys Cys Pro Asp Asp Phe Tyr 
465                 470                 475                 480 


Val Glu Asp Gly Ile Pro Cys Lys Glu Arg Gly Tyr Cys Tyr Glu Lys 
                485                 490                 495     


Ser Cys His Asp Arg Asn Glu Gln Cys Arg Arg Ile Phe Gly Ala Gly 
            500                 505                 510         


Ala Asn Thr Ala Ser Glu Thr Cys Tyr Lys Glu Leu Asn Thr Leu Gly 
        515                 520                 525             


Asp Arg Val Gly His Cys Gly Ile Lys Asn Ala Thr Tyr Ile Lys Cys 
    530                 535                 540                 


Asn Ile Ser Asp Val Gln Cys Gly Arg Ile Gln Cys Glu Asn Val Thr 
545                 550                 555                 560 


Glu Ile Pro Asn Met Ser Asp His Thr Thr Val His Trp Ala Arg Phe 
                565                 570                 575     


Asn Asp Ile Met Cys Trp Ser Thr Asp Tyr His Leu Gly Met Lys Gly 
            580                 585                 590         


Pro Asp Ile Gly Glu Val Lys Asp Gly Thr Glu Cys Gly Ile Asp His 
        595                 600                 605             


Ile Cys Ile His Arg His Cys Val His Ile Thr Ile Leu Asn Ser Asn 
    610                 615                 620                 


Cys Ser Pro Ala Phe Cys Asn Lys Arg Gly Ile Cys Asn Asn Lys His 
625                 630                 635                 640 


His Cys His Cys Asn Tyr Leu Trp Asp Pro Pro Asn Cys Leu Ile Lys 
                645                 650                 655     


Gly Tyr Gly Gly Ser Val Asp Ser Gly Pro Pro Pro Lys Arg Lys Lys 
            660                 665                 670         


Lys Lys Lys Phe Cys Tyr Leu Cys Ile Leu Leu Leu Ile Val Leu Phe 
        675                 680                 685             


Ile Leu Leu Cys Cys Leu Tyr Arg Leu Cys Lys Lys Ser Lys Pro Ile 
    690                 695                 700                 


Lys Lys Gln Gln Asp Val Gln Thr Pro Ser Ala Lys Glu Glu Glu Lys 
705                 710                 715                 720 


Ile Gln Arg Arg Pro His Glu Leu Pro Pro Gln Ser Gln Pro Trp Val 
                725                 730                 735     


Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser His Pro 
            740                 745                 750         


Gln Val Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser 
        755                 760                 765             


Gln Pro Arg Val Met Pro Ser Gln Ser Gln Pro Pro Val Met Pro Ser 
    770                 775                 780                 


Gln Ser His Pro Gln Leu Thr Pro Ser Gln Ser Gln Pro Pro Val Thr 
785                 790                 795                 800 


Pro Ser Gln Arg Gln Pro Gln Leu Met Pro Ser Gln Ser Gln Pro Pro 
                805                 810                 815     


Val Thr Pro Ser 
            820 


<210>  1438
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  1438

Met Asn Met Ser Val Leu Thr Leu Gln Glu Tyr Glu Phe Glu Lys Gln 
1               5                   10                  15      


Phe Asn Glu Asn Glu Ala Ile Gln Trp Met Gln Glu Asn Trp Lys Lys 
            20                  25                  30          


Ser Phe Leu Phe Ser Ala Leu Tyr Ala Ala Phe Ile Phe Gly Gly Arg 
        35                  40                  45              


His Leu Met Asn Lys Arg Ala Lys Phe Glu Leu Arg Lys Pro Leu Val 
    50                  55                  60                  


Leu Trp Ser Leu Thr Leu Ala Val Phe Ser Ile Phe Gly Ala Leu Arg 
65                  70                  75                  80  


Thr Gly Ala Tyr Met Val Tyr Ile Leu Met Thr Lys Gly Leu Lys Gln 
                85                  90                  95      


Ser Val Cys Asp Gln Gly Phe Tyr Asn Gly Pro Val Ser Lys Phe Trp 
            100                 105                 110         


Ala Tyr Ala Phe Val Leu Ser Lys Ala Pro Glu Leu Gly Asp Thr Ile 
        115                 120                 125             


Phe Ile Ile Leu Arg Lys Gln Lys Leu Ile Phe Leu His Trp Tyr His 
    130                 135                 140                 


His Ile Thr Val Leu Leu Tyr Ser Trp Tyr Ser Tyr Lys Asp Met Val 
145                 150                 155                 160 


Ala Gly Gly Gly Trp Phe Met Thr Met Asn Tyr Gly Val His Ala Val 
                165                 170                 175     


Met Tyr Ser Tyr Tyr Ala Leu Arg Ala Ala Gly Phe Arg Val Ser Arg 
            180                 185                 190         


Lys Phe Ala Met Phe Ile Thr Leu Ser Gln Ile Thr Gln Met Leu Met 
        195                 200                 205             


Gly Cys Val Val Asn Tyr Leu Val Phe Cys Trp Met Gln His Asp Gln 
    210                 215                 220                 


Cys His Ser His Phe Gln Asn Ile Phe Trp Ser Ser Leu Met Tyr Leu 
225                 230                 235                 240 


Ser Tyr Leu Val Leu Phe Cys His Phe Phe Phe Glu Ala Tyr Ile Gly 
                245                 250                 255     


Lys Met Arg Lys Thr Thr Lys Ala Glu 
            260                 265 


<210>  1439
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  1439

Met Gly Lys Ile Leu Pro Glu Tyr Leu Ser Asn Trp Thr Met Glu Lys 
1               5                   10                  15      


Val Arg Arg Glu Gly Val Lys Val Met Pro Asn Ala Ile Val Gln Ser 
            20                  25                  30          


Val Gly Val Ser Ser Gly Lys Leu Leu Ile Lys Leu Lys Asp Gly Arg 
        35                  40                  45              


Lys Val Glu Thr Asp His Ile Val Ala Ala Val Gly Leu Glu Pro Asn 
    50                  55                  60                  


Val Glu Leu Ala Lys Thr Gly Gly Leu Glu Ile Asp Ser Asp Phe Gly 
65                  70                  75                  80  


Gly Phe Arg Val Asn Ala Glu Leu Gln Ala Arg Ser Asn Ile Trp Val 
                85                  90                  95      


Ala Gly Asp Ala Ala Cys Phe Tyr Asp Ile Lys Leu Gly Arg Arg Arg 
            100                 105                 110         


Val Glu His His Asp His Ala Val Val Ser Gly Arg Leu Ala Gly Glu 
        115                 120                 125             


Asn Met Thr Gly Ala Ala Lys Pro Tyr Trp His Gln Ser Met Phe Trp 
    130                 135                 140                 


Ser Asp Leu Gly Pro Asp Val Gly Tyr Glu Ala Ile Gly Leu Val Asp 
145                 150                 155                 160 


Ser Ser Leu Pro Thr Val Gly Val Phe Ala Lys Ala Thr Ala Gln Asp 
                165                 170                 175     


Asn Pro Lys Ser Ala Thr Glu Gln Ser Gly Thr Gly Ile Arg Ser Glu 
            180                 185                 190         


Ser Glu Thr Glu Ser Glu Ala Ser Glu Ile Thr Ile Pro Pro Ser Thr 
        195                 200                 205             


Pro Ala Val Pro Gln Ala Pro Val Gln Gly Glu Asp Tyr Gly Lys Gly 
    210                 215                 220                 


Val Ile Phe Tyr Leu Arg Asp Lys Val Val Val Gly Ile Val Leu Trp 
225                 230                 235                 240 


Asn Ile Phe Asn Arg Met Pro Ile Ala Arg Lys Ile Ile Lys Asp Gly 
                245                 250                 255     


Glu Gln His Glu Asp Leu Asn Glu Val Ala Lys Leu Phe Asn Ile His 
            260                 265                 270         


Glu Asp 
        


<210>  1440
<211>  324
<212>  PRT
<213>  Homo sapiens

<400>  1440

Met Phe Arg Cys Gly Gly Leu Ala Ala Gly Ala Leu Lys Gln Lys Leu 
1               5                   10                  15      


Val Pro Leu Val Arg Thr Val Cys Val Arg Ser Pro Arg Gln Arg Asn 
            20                  25                  30          


Arg Leu Pro Gly Asn Leu Phe Gln Arg Trp His Val Pro Leu Glu Leu 
        35                  40                  45              


Gln Met Thr Arg Gln Met Ala Ser Ser Gly Ala Ser Gly Gly Lys Ile 
    50                  55                  60                  


Asp Asn Ser Val Leu Val Leu Ile Val Gly Leu Ser Thr Val Gly Ala 
65                  70                  75                  80  


Gly Ala Tyr Ala Tyr Lys Thr Met Lys Glu Asp Glu Lys Arg Tyr Asn 
                85                  90                  95      


Glu Arg Ile Ser Gly Leu Gly Leu Thr Pro Glu Gln Lys Gln Lys Lys 
            100                 105                 110         


Ala Ala Leu Ser Ala Ser Glu Gly Glu Glu Val Pro Gln Asp Lys Ala 
        115                 120                 125             


Pro Ser His Val Pro Phe Leu Leu Ile Gly Gly Gly Thr Ala Ala Phe 
    130                 135                 140                 


Ala Ala Ala Arg Ser Ile Arg Ala Arg Asp Pro Gly Ala Arg Val Leu 
145                 150                 155                 160 


Ile Val Ser Glu Asp Pro Glu Leu Pro Tyr Met Arg Pro Pro Leu Ser 
                165                 170                 175     


Lys Glu Leu Trp Phe Ser Asp Asp Pro Asn Val Thr Lys Thr Leu Arg 
            180                 185                 190         


Phe Lys Gln Trp Asn Gly Lys Glu Arg Ser Ile Tyr Phe Gln Pro Pro 
        195                 200                 205             


Ser Phe Tyr Val Ser Ala Gln Asp Leu Pro His Ile Glu Asn Gly Gly 
    210                 215                 220                 


Val Ala Val Leu Thr Gly Lys Lys Val Val Gln Leu Asp Val Arg Asp 
225                 230                 235                 240 


Asn Met Val Lys Leu Asn Asp Gly Ser Gln Ile Thr Tyr Glu Lys Cys 
                245                 250                 255     


Leu Ile Ala Thr Gly Gly Thr Pro Arg Ser Leu Ser Ala Ile Asp Arg 
            260                 265                 270         


Ala Gly Ala Glu Val Lys Ser Arg Thr Thr Leu Phe Arg Lys Ile Gly 
        275                 280                 285             


Asp Phe Arg Ser Leu Glu Lys Ile Ser Arg Glu Val Lys Ser Ile Thr 
    290                 295                 300                 


Ile Ile Gly Gly Gly Phe Leu Gly Ser Glu Leu Ala Cys Ala Leu Gly 
305                 310                 315                 320 


Arg Lys Asp Ile 
                


<210>  1441
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  1441

Met Lys Pro Pro Ser Ser Ile Gln Thr Ser Cys Lys Phe Lys Asp Val 
1               5                   10                  15      


Arg Arg Asn Val Gln Lys Asp Thr Glu Glu Leu Lys Ser Cys Gly Ile 
            20                  25                  30          


Gln Asp Ile Phe Val Phe Cys Thr Arg Gly Glu Leu Ser Lys Tyr Arg 
        35                  40                  45              


Val Pro Asn Leu Leu Asp Leu Tyr Gln Gln Cys Gly Ile Ile Thr His 
    50                  55                  60                  


His His Pro Ile Ala Asp Gly Gly Thr Pro Asp Ile Ala Ser Cys Cys 
65                  70                  75                  80  


Glu Ile Met Glu Glu Leu Thr Thr Cys Leu Lys Asn Tyr Arg Lys Thr 
                85                  90                  95      


Leu Ile His Cys Tyr Gly Gly Leu Gly Arg Ser Cys Leu Val Ala Ala 
            100                 105                 110         


Cys Leu Leu Leu Tyr Leu Ser Asp Thr Ile Ser Pro Glu Gln Ala Ile 
        115                 120                 125             


Asp Ser Leu Arg Asp Leu Arg Gly Ser Gly Ala Ile Gln Thr Ile Lys 
    130                 135                 140                 


Gln Tyr Asn Tyr Leu His Glu Phe Arg Asp Lys Leu Ala Ala His Leu 
145                 150                 155                 160 


Ser Ser Arg Asp Ser Gln Ser Arg Ser Val Ser Arg 
                165                 170         


<210>  1442
<211>  1160
<212>  PRT
<213>  Homo sapiens

<400>  1442

Met Trp Ala Met Glu Ser Gly His Leu Leu Trp Ala Leu Leu Phe Met 
1               5                   10                  15      


Gln Ser Leu Trp Pro Gln Leu Thr Asp Gly Ala Thr Arg Val Tyr Tyr 
            20                  25                  30          


Leu Gly Ile Arg Asp Val Gln Trp Asn Tyr Ala Pro Lys Gly Arg Asn 
        35                  40                  45              


Val Ile Thr Asn Gln Pro Leu Asp Ser Asp Ile Val Ala Ser Ser Phe 
    50                  55                  60                  


Leu Lys Ser Asp Lys Asn Arg Ile Gly Gly Thr Tyr Lys Lys Thr Ile 
65                  70                  75                  80  


Tyr Lys Glu Tyr Lys Asp Asp Ser Tyr Thr Asp Glu Val Ala Gln Pro 
                85                  90                  95      


Ala Trp Leu Gly Phe Leu Gly Pro Val Leu Gln Ala Glu Val Gly Asp 
            100                 105                 110         


Val Ile Leu Ile His Leu Lys Asn Phe Ala Thr Arg Pro Tyr Thr Ile 
        115                 120                 125             


His Pro His Gly Val Phe Tyr Glu Lys Asp Ser Glu Gly Ser Leu Tyr 
    130                 135                 140                 


Pro Asp Gly Ser Ser Gly Pro Leu Lys Ala Asp Asp Ser Val Pro Pro 
145                 150                 155                 160 


Gly Gly Ser His Ile Tyr Asn Trp Thr Ile Pro Glu Gly His Ala Pro 
                165                 170                 175     


Thr Asp Ala Asp Pro Ala Cys Leu Thr Trp Ile Tyr His Ser His Val 
            180                 185                 190         


Asp Ala Pro Arg Asp Ile Ala Thr Gly Leu Ile Gly Pro Leu Ile Thr 
        195                 200                 205             


Cys Lys Arg Gly Ala Leu Asp Gly Asn Ser Pro Pro Gln Arg Gln Asp 
    210                 215                 220                 


Val Asp His Asp Phe Phe Leu Leu Phe Ser Val Val Asp Glu Asn Leu 
225                 230                 235                 240 


Ser Trp His Leu Asn Glu Asn Ile Ala Thr Tyr Cys Ser Asp Pro Ala 
                245                 250                 255     


Ser Val Asp Lys Glu Asp Glu Thr Phe Gln Glu Ser Asn Arg Met His 
            260                 265                 270         


Ala Ile Asn Gly Phe Val Phe Gly Asn Leu Pro Glu Leu Asn Met Cys 
        275                 280                 285             


Ala Gln Lys Arg Val Ala Trp His Leu Phe Gly Met Gly Asn Glu Ile 
    290                 295                 300                 


Asp Val His Thr Ala Phe Phe His Gly Gln Met Leu Thr Thr Arg Gly 
305                 310                 315                 320 


His His Thr Asp Val Ala Asn Ile Phe Pro Ala Thr Phe Val Thr Ala 
                325                 330                 335     


Glu Met Val Pro Trp Glu Pro Gly Thr Trp Leu Ile Ser Cys Gln Val 
            340                 345                 350         


Asn Ser His Phe Arg Asp Gly Met Gln Ala Leu Tyr Lys Val Lys Ser 
        355                 360                 365             


Cys Ser Met Ala Pro Pro Val Asp Leu Leu Thr Gly Lys Val Arg Gln 
    370                 375                 380                 


Tyr Phe Ile Glu Ala His Glu Ile Gln Trp Asp Tyr Gly Pro Met Gly 
385                 390                 395                 400 


His Asp Gly Ser Thr Gly Lys Asn Leu Arg Glu Pro Gly Ser Ile Ser 
                405                 410                 415     


Asp Lys Phe Phe Gln Lys Ser Ser Ser Arg Ile Gly Gly Thr Tyr Trp 
            420                 425                 430         


Lys Val Arg Tyr Glu Ala Phe Gln Asp Glu Thr Phe Gln Glu Lys Met 
        435                 440                 445             


His Leu Glu Glu Asp Arg His Leu Gly Ile Leu Gly Pro Val Ile Arg 
    450                 455                 460                 


Ala Glu Val Gly Asp Thr Ile Gln Val Val Phe Tyr Asn Arg Ala Ser 
465                 470                 475                 480 


Gln Pro Phe Ser Met Gln Pro His Gly Val Phe Tyr Glu Lys Asp Tyr 
                485                 490                 495     


Glu Gly Thr Val Tyr Asn Asp Gly Ser Ser Tyr Pro Gly Leu Val Ala 
            500                 505                 510         


Lys Pro Phe Glu Lys Val Thr Tyr Arg Trp Thr Val Pro Pro His Ala 
        515                 520                 525             


Gly Pro Thr Ala Gln Asp Pro Ala Cys Leu Thr Trp Met Tyr Phe Ser 
    530                 535                 540                 


Ala Ala Asp Pro Ile Arg Asp Thr Asn Ser Gly Leu Val Gly Pro Leu 
545                 550                 555                 560 


Leu Val Cys Arg Ala Gly Ala Leu Gly Ala Asp Gly Lys Gln Lys Gly 
                565                 570                 575     


Val Asp Lys Glu Phe Phe Leu Leu Phe Thr Val Leu Asp Glu Asn Lys 
            580                 585                 590         


Ser Trp Tyr Ser Asn Ala Asn Gln Ala Ala Ala Met Leu Asp Phe Arg 
        595                 600                 605             


Leu Leu Ser Glu Asp Ile Glu Gly Phe Gln Asp Ser Asn Arg Met His 
    610                 615                 620                 


Ala Ile Asn Gly Phe Leu Phe Ser Asn Leu Pro Arg Leu Asp Met Cys 
625                 630                 635                 640 


Lys Gly Asp Thr Val Ala Trp His Leu Leu Gly Leu Gly Thr Glu Thr 
                645                 650                 655     


Asp Val His Gly Val Met Phe Gln Gly Asn Thr Val Gln Leu Gln Gly 
            660                 665                 670         


Met Arg Lys Gly Ala Ala Met Leu Phe Pro His Thr Phe Val Met Ala 
        675                 680                 685             


Ile Met Gln Pro Asp Asn Leu Gly Thr Phe Glu Ile Tyr Cys Gln Ala 
    690                 695                 700                 


Gly Ser His Arg Glu Ala Gly Met Arg Ala Ile Tyr Asn Val Ser Gln 
705                 710                 715                 720 


Cys Pro Gly His Gln Ala Thr Pro Arg Gln Arg Tyr Gln Ala Ala Arg 
                725                 730                 735     


Ile Tyr Tyr Ile Met Ala Glu Glu Val Glu Trp Asp Tyr Cys Pro Asp 
            740                 745                 750         


Arg Ser Trp Glu Arg Glu Trp His Asn Gln Ser Glu Lys Asp Ser Tyr 
        755                 760                 765             


Gly Tyr Ile Phe Leu Ser Asn Lys Asp Gly Leu Leu Gly Ser Arg Tyr 
    770                 775                 780                 


Lys Lys Ala Val Phe Arg Glu Tyr Thr Asp Gly Thr Phe Arg Ile Pro 
785                 790                 795                 800 


Arg Pro Arg Thr Gly Pro Glu Glu His Leu Gly Ile Leu Gly Pro Leu 
                805                 810                 815     


Ile Lys Gly Glu Val Gly Asp Ile Leu Thr Val Val Phe Lys Asn Asn 
            820                 825                 830         


Ala Ser Arg Pro Tyr Ser Val His Ala His Gly Val Leu Glu Ser Thr 
        835                 840                 845             


Thr Val Trp Pro Leu Ala Ala Glu Pro Gly Glu Val Val Thr Tyr Gln 
    850                 855                 860                 


Trp Asn Ile Pro Glu Arg Ser Gly Pro Gly Pro Asn Asp Ser Ala Cys 
865                 870                 875                 880 


Val Ser Trp Ile Tyr Tyr Ser Ala Val Asp Pro Ile Lys Asp Met Tyr 
                885                 890                 895     


Ser Gly Leu Val Gly Pro Leu Ala Ile Cys Gln Lys Gly Ile Leu Glu 
            900                 905                 910         


Pro His Gly Gly Arg Ser Asp Met Asp Arg Glu Phe Ala Leu Leu Phe 
        915                 920                 925             


Leu Ile Phe Asp Glu Asn Lys Ser Trp Tyr Leu Glu Glu Asn Val Ala 
    930                 935                 940                 


Thr His Gly Ser Gln Asp Pro Gly Ser Ile Asn Leu Gln Asp Glu Thr 
945                 950                 955                 960 


Phe Leu Glu Ser Asn Lys Met His Ala Ile Asn Gly Lys Leu Tyr Ala 
                965                 970                 975     


Asn Leu Arg Gly Leu Thr Met Tyr Gln Gly Glu Arg Val Ala Trp Tyr 
            980                 985                 990         


Met Leu Ala Met Gly Gln Asp Val  Asp Leu His Thr Ile  His Phe His 
        995                 1000                 1005             


Ala Glu  Ser Phe Leu Tyr Arg  Asn Gly Glu Asn Tyr  Arg Ala Asp 
    1010                 1015                 1020             


Val Val  Asp Leu Phe Pro Gly  Thr Phe Glu Val Val  Glu Met Val 
    1025                 1030                 1035             


Ala Ser  Asn Pro Gly Thr Trp  Leu Met His Cys His  Val Thr Asp 
    1040                 1045                 1050             


His Val  His Ala Gly Met Glu  Thr Leu Phe Thr Val  Phe Ser Arg 
    1055                 1060                 1065             


Thr Glu  His Leu Ser Pro Leu  Thr Val Ile Thr Lys  Glu Thr Glu 
    1070                 1075                 1080             


Lys Val  Pro Pro Arg Asp Ile  Glu Glu Gly Asn Val  Lys Met Leu 
    1085                 1090                 1095             


Gly Met  Gln Ile Pro Ile Lys  Asn Val Glu Met Leu  Ala Ser Val 
    1100                 1105                 1110             


Leu Val  Ala Ile Ser Val Thr  Leu Leu Leu Val Val  Leu Ala Leu 
    1115                 1120                 1125             


Gly Gly  Val Val Trp Tyr Gln  His Arg Gln Arg Lys  Leu Arg Arg 
    1130                 1135                 1140             


Asn Arg  Arg Ser Ile Leu Asp  Asp Ser Phe Lys Leu  Leu Ser Phe 
    1145                 1150                 1155             


Lys Gln  
    1160 


<210>  1443
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  1443

Met Thr Arg Ala Arg Ile Gly Cys Phe Gly Pro Gly Gly Arg Ala Arg 
1               5                   10                  15      


Gly Thr Glu Ser Ala Pro Glu Pro Ser Lys Arg Val Pro Pro Gly Arg 
            20                  25                  30          


Ser Trp Gln Thr Gln Glu Val Arg Gln Thr Arg Gly Ala Asn Gly Leu 
        35                  40                  45              


Gly Pro Arg Ala Gly Ser Ala Gly Ala Lys Ala Pro Gly Pro Ala Gln 
    50                  55                  60                  


Gly Ala Ala Gln His Gly Leu Gly Gly Ser Ala Gly Leu Arg Val Arg 
65                  70                  75                  80  


Val Ser Pro Leu Ala Met Gly Ser Ala Ala Leu Glu Ile Leu Gly Leu 
                85                  90                  95      


Val Leu Cys Leu Val Gly Trp Gly Gly Leu Ile Leu Ala Cys Gly Leu 
            100                 105                 110         


Pro Met Trp Gln Val Thr Ala Phe Leu Asp His Asn Ile Val Thr Ala 
        115                 120                 125             


Gln Thr Thr Trp Lys Gly Leu Trp Met Ser Cys Val Val Gln Ser Thr 
    130                 135                 140                 


Gly His Met Gln Cys Lys Val Tyr Asp Ser Val Leu Ala Leu Ser Thr 
145                 150                 155                 160 


Glu Val Gln Ala Ala Arg Ala Leu Thr Val Ser Ala Val Leu Leu Ala 
                165                 170                 175     


Phe Val Ala Leu Phe Val Thr Leu Ala Gly Ala Gln Cys Thr Thr Cys 
            180                 185                 190         


Val Ala Pro Gly Pro Ala Lys Ala Arg Val Ala Leu Thr Gly Gly Val 
        195                 200                 205             


Leu Tyr Leu Phe Cys Gly Leu Leu Ala Leu Val Pro Leu Cys Trp Phe 
    210                 215                 220                 


Ala Asn Ile Val Val Arg Glu Phe Tyr Asp Pro Ser Val Pro Val Ser 
225                 230                 235                 240 


Gln Lys Tyr Glu Leu Gly Ala Ala Leu Tyr Ile Gly Trp Ala Ala Thr 
                245                 250                 255     


Ala Leu Leu Met Val Gly Gly Cys Leu Leu Cys Cys Gly Ala Trp Val 
            260                 265                 270         


Cys Thr Gly Arg Pro Asp Leu Ser Phe Pro Val Lys Tyr Ser Ala Pro 
        275                 280                 285             


Arg Arg Pro Thr Ala Thr Gly Asp Tyr Asp Lys Lys Asn Tyr Val 
    290                 295                 300             


<210>  1444
<211>  888
<212>  PRT
<213>  Homo sapiens

<400>  1444

Met Ala Arg Arg Ser Ser Phe Gln Ser Cys Gln Ile Ile Ser Leu Phe 
1               5                   10                  15      


Thr Phe Ala Val Gly Val Asn Ile Cys Leu Gly Phe Thr Ala His Arg 
            20                  25                  30          


Ile Lys Arg Ala Glu Gly Trp Glu Glu Gly Pro Pro Thr Val Leu Ser 
        35                  40                  45              


Asp Ser Pro Trp Thr Asn Ile Ser Gly Ser Cys Lys Gly Arg Cys Phe 
    50                  55                  60                  


Glu Leu Gln Glu Ala Gly Pro Pro Asp Cys Arg Cys Asp Asn Leu Cys 
65                  70                  75                  80  


Lys Ser Tyr Thr Ser Cys Cys His Asp Phe Asp Glu Leu Cys Leu Lys 
                85                  90                  95      


Thr Ala Arg Gly Trp Glu Cys Thr Lys Asp Arg Cys Gly Glu Val Arg 
            100                 105                 110         


Asn Glu Glu Asn Ala Cys His Cys Ser Glu Asp Cys Leu Ala Arg Gly 
        115                 120                 125             


Asp Cys Cys Thr Asn Tyr Gln Val Val Cys Lys Gly Glu Ser His Trp 
    130                 135                 140                 


Val Asp Asp Asp Cys Glu Glu Ile Lys Ala Ala Glu Cys Pro Ala Gly 
145                 150                 155                 160 


Phe Val Arg Pro Pro Leu Ile Ile Phe Ser Val Asp Gly Phe Arg Ala 
                165                 170                 175     


Ser Tyr Met Lys Lys Gly Ser Lys Val Met Pro Asn Ile Glu Lys Leu 
            180                 185                 190         


Arg Ser Cys Gly Thr His Ser Pro Tyr Met Arg Pro Val Tyr Pro Thr 
        195                 200                 205             


Lys Thr Phe Pro Asn Leu Tyr Thr Leu Ala Thr Gly Leu Tyr Pro Glu 
    210                 215                 220                 


Ser His Gly Ile Val Gly Asn Ser Met Tyr Asp Pro Val Phe Asp Ala 
225                 230                 235                 240 


Thr Phe His Leu Arg Gly Arg Glu Lys Phe Asn His Arg Trp Trp Gly 
                245                 250                 255     


Gly Gln Pro Leu Trp Ile Thr Ala Thr Lys Gln Gly Val Lys Ala Gly 
            260                 265                 270         


Thr Phe Phe Trp Ser Val Val Ile Pro His Glu Arg Arg Ile Leu Thr 
        275                 280                 285             


Ile Leu Gln Trp Leu Thr Leu Pro Asp His Glu Arg Pro Ser Val Tyr 
    290                 295                 300                 


Ala Phe Tyr Ser Glu Gln Pro Asp Phe Ser Gly His Lys Tyr Gly Pro 
305                 310                 315                 320 


Phe Gly Pro Glu Met Thr Asn Pro Leu Arg Glu Ile Asp Lys Ile Val 
                325                 330                 335     


Gly Gln Leu Met Asp Gly Leu Lys Gln Leu Lys Leu His Arg Cys Val 
            340                 345                 350         


Asn Val Ile Phe Val Gly Asp His Gly Met Glu Asp Val Thr Cys Asp 
        355                 360                 365             


Arg Thr Glu Phe Leu Ser Asn Tyr Leu Thr Asn Val Asp Asp Ile Thr 
    370                 375                 380                 


Leu Val Pro Gly Thr Leu Gly Arg Ile Arg Ser Lys Phe Ser Asn Asn 
385                 390                 395                 400 


Ala Lys Tyr Asp Pro Lys Ala Ile Ile Ala Asn Leu Thr Cys Lys Lys 
                405                 410                 415     


Pro Asp Gln His Phe Lys Pro Tyr Leu Lys Gln His Leu Pro Lys Arg 
            420                 425                 430         


Leu His Tyr Ala Asn Asn Arg Arg Ile Glu Asp Ile His Leu Leu Val 
        435                 440                 445             


Glu Arg Arg Trp His Val Ala Arg Lys Pro Leu Asp Val Tyr Lys Lys 
    450                 455                 460                 


Pro Ser Gly Lys Cys Phe Phe Gln Gly Asp His Gly Phe Asp Asn Lys 
465                 470                 475                 480 


Val Asn Ser Met Gln Thr Val Phe Val Gly Tyr Gly Ser Thr Phe Lys 
                485                 490                 495     


Tyr Lys Thr Lys Val Pro Pro Phe Glu Asn Ile Glu Leu Tyr Asn Val 
            500                 505                 510         


Met Cys Asp Leu Leu Gly Leu Lys Pro Ala Pro Asn Asn Gly Thr His 
        515                 520                 525             


Gly Ser Leu Asn His Leu Leu Arg Thr Asn Thr Phe Arg Pro Thr Met 
    530                 535                 540                 


Pro Glu Glu Val Thr Arg Pro Asn Tyr Pro Gly Ile Met Tyr Leu Gln 
545                 550                 555                 560 


Ser Asp Phe Asp Leu Gly Cys Thr Cys Asp Asp Lys Val Glu Pro Lys 
                565                 570                 575     


Asn Lys Leu Asp Glu Leu Asn Lys Arg Leu His Thr Lys Gly Ser Thr 
            580                 585                 590         


Glu Ala Glu Thr Arg Lys Phe Arg Gly Ser Arg Asn Glu Asn Lys Glu 
        595                 600                 605             


Asn Ile Asn Gly Asn Phe Glu Pro Arg Lys Glu Arg His Leu Leu Tyr 
    610                 615                 620                 


Gly Arg Pro Ala Val Leu Tyr Arg Thr Arg Tyr Asp Ile Leu Tyr His 
625                 630                 635                 640 


Thr Asp Phe Glu Ser Gly Tyr Ser Glu Ile Phe Leu Met Pro Leu Trp 
                645                 650                 655     


Thr Ser Tyr Thr Val Ser Lys Gln Ala Glu Val Ser Ser Val Pro Asp 
            660                 665                 670         


His Leu Thr Ser Cys Val Arg Pro Asp Val Arg Val Ser Pro Ser Phe 
        675                 680                 685             


Ser Gln Asn Cys Leu Ala Tyr Lys Asn Asp Lys Gln Met Ser Tyr Gly 
    690                 695                 700                 


Phe Leu Phe Pro Pro Tyr Leu Ser Ser Ser Pro Glu Ala Lys Tyr Asp 
705                 710                 715                 720 


Ala Phe Leu Val Thr Asn Met Val Pro Met Tyr Pro Ala Phe Lys Arg 
                725                 730                 735     


Val Trp Asn Tyr Phe Gln Arg Val Leu Val Lys Lys Tyr Ala Ser Glu 
            740                 745                 750         


Arg Asn Gly Val Asn Val Ile Ser Gly Pro Ile Phe Asp Tyr Asp Tyr 
        755                 760                 765             


Asp Gly Leu His Asp Thr Glu Asp Lys Ile Lys Gln Tyr Val Glu Gly 
    770                 775                 780                 


Ser Ser Ile Pro Val Pro Thr His Tyr Tyr Ser Ile Ile Thr Ser Cys 
785                 790                 795                 800 


Leu Asp Phe Thr Gln Pro Ala Asp Lys Cys Asp Gly Pro Leu Ser Val 
                805                 810                 815     


Ser Ser Phe Ile Leu Pro His Arg Pro Asp Asn Glu Glu Ser Cys Asn 
            820                 825                 830         


Ser Ser Glu Asp Glu Ser Lys Trp Val Glu Glu Leu Met Lys Met His 
        835                 840                 845             


Thr Ala Arg Val Arg Asp Ile Glu His Leu Thr Ser Leu Asp Phe Phe 
    850                 855                 860                 


Arg Lys Thr Ser Arg Ser Tyr Pro Glu Ile Leu Thr Leu Lys Thr Tyr 
865                 870                 875                 880 


Leu His Thr Tyr Glu Ser Glu Ile 
                885             


<210>  1445
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  1445

Met Ala Asp Pro Gln Ala Gly Ser Ala Ala Gly Asp Trp Glu Ile Asp 
1               5                   10                  15      


Val Glu Ser Leu Glu Leu Glu Glu Asp Val Cys Gly Ala Pro Arg Ser 
            20                  25                  30          


Thr Pro Pro Gly Pro Ser Pro Pro Pro Ala Asp Gly Asp Cys Glu Asp 
        35                  40                  45              


Asp Glu Asp Asp Asp Gly Val Asp Glu Asp Ala Glu Glu Glu Gly Asp 
    50                  55                  60                  


Gly Glu Glu Ala Gly Ala Ser Pro Gly Met Pro Gly Gln Pro Glu Gln 
65                  70                  75                  80  


Arg Gly Gly Pro Gln Pro Arg Pro Pro Leu Ala Pro Gln Ala Ser Pro 
                85                  90                  95      


Ala Gly Thr Gly Pro Arg Glu Arg Cys Thr Pro Ala Gly Gly Gly Ala 
            100                 105                 110         


Glu Pro Arg Lys Leu Ser Arg Thr Pro Lys Cys Ala Arg Cys Arg Asn 
        115                 120                 125             


His Gly Val Val Ser Cys Leu Lys Gly His Lys Arg Phe Cys Arg Trp 
    130                 135                 140                 


Arg Asp Cys Gln Cys Ala Asn Cys Leu Leu Val Val Glu Arg Gln Arg 
145                 150                 155                 160 


Val Met Ala Ala Gln Val Ala Leu Arg Arg Gln Gln Ala Thr Glu Asp 
                165                 170                 175     


Lys Lys Gly Leu Ser Gly Lys Gln Asn Asn Phe Glu Arg Lys Ala Val 
            180                 185                 190         


Tyr Gln Arg Gln Val Arg Ala Pro Ser Leu Leu Ala Lys Ser Ile Leu 
        195                 200                 205             


Glu Val Leu Leu Gly Leu Phe Tyr Ser Tyr Tyr Val Tyr Ile Met Asn 
    210                 215                 220                 


His Leu 
225     


<210>  1446
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  1446

Met Ile Tyr Thr Arg Phe Leu Lys Gly Ser Leu Lys Met Ala Asn Tyr 
1               5                   10                  15      


Thr Leu Ala Pro Glu Asp Glu Tyr Asp Val Leu Ile Glu Gly Glu Leu 
            20                  25                  30          


Glu Ser Asp Glu Ala Glu Gln Cys Asp Lys Tyr Asp Ala Gln Ala Leu 
        35                  40                  45              


Ser Ala Gln Leu Val Pro Ser Leu Cys Ser Ala Val Phe Val Ile Gly 
    50                  55                  60                  


Val Leu Asp Asn Leu Leu Val Val Leu Ile Leu Val Lys Tyr Lys Gly 
65                  70                  75                  80  


Leu Lys Arg Val Glu Asn Ile Tyr Leu Leu Asn Leu Ala Val Ser Asn 
                85                  90                  95      


Leu Cys Phe Leu Leu Thr Leu Pro Phe Trp Ala His Ala Gly Gly Asp 
            100                 105                 110         


Pro Met Cys Lys Ile Leu Ile Gly Leu Tyr Phe Val Gly Leu Tyr Ser 
        115                 120                 125             


Glu Thr Phe Phe Asn Cys Leu Leu Thr Val Gln Arg Tyr Leu Val Phe 
    130                 135                 140                 


Leu His Lys Gly Asn Phe Phe Ser Ala Arg Arg Arg Val Pro Cys Gly 
145                 150                 155                 160 


Ile Ile Thr Ser Val Leu Ala Trp Val Thr Ala Ile Leu Ala Thr Leu 
                165                 170                 175     


Pro Glu Phe Val Val Tyr Lys Pro Gln Met Glu Asp Gln Lys Tyr Lys 
            180                 185                 190         


Cys Ala Phe Ser Arg Thr Pro Phe Leu Pro Ala Asp Glu Thr Phe Trp 
        195                 200                 205             


Lys His Phe Leu Thr Leu Lys Met Asn Ile Ser Val Leu Val Leu Pro 
    210                 215                 220                 


Leu Phe Ile Phe Thr Phe Leu Tyr Val Gln Met Arg Lys Thr Leu Arg 
225                 230                 235                 240 


Phe Arg Glu Gln Arg Tyr Ser Leu Phe Lys Leu Val Phe Ala Ile Met 
                245                 250                 255     


Val Val Phe Leu Leu Met Trp Ala Pro Tyr Asn Ile Ala Phe Phe Leu 
            260                 265                 270         


Ser Thr Phe Lys Glu His Phe Ser Leu Ser Asp Cys Lys Ser Ser Tyr 
        275                 280                 285             


Asn Leu Asp Lys Ser Val His Ile Thr Lys Leu Ile Ala Thr Thr His 
    290                 295                 300                 


Cys Cys Ile Asn Pro Leu Leu Tyr Ala Phe Leu Asp Gly Thr Phe Ser 
305                 310                 315                 320 


Lys Tyr Leu Cys Arg Cys Phe His Leu Arg Ser Asn Thr Pro Leu Gln 
                325                 330                 335     


Pro Arg Gly Gln Ser Ala Gln Gly Thr Ser Arg Glu Glu Pro Asp His 
            340                 345                 350         


Ser Thr Glu Val 
        355     


<210>  1447
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  1447

Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr 
            20                  25                  30          


Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys 
        35                  40                  45              


Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys 
    50                  55                  60                  


Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg 
65                  70                  75                  80  


Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr 
                85                  90                  95      


Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro 
            100                 105                 110         


Thr Thr Gly Leu Pro Leu Leu Val Gln Arg Thr Ile Ala Arg Thr Ile 
        115                 120                 125             


Val Leu Gln Glu Ser Ile Gly Lys Gly Arg Phe Gly Glu Val Trp Arg 
    130                 135                 140                 


Gly Lys Trp Arg Gly Glu Glu Val Ala Val Lys Ile Phe Ser Ser Arg 
145                 150                 155                 160 


Glu Glu Arg Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Thr Val Met 
                165                 170                 175     


Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys Asp 
            180                 185                 190         


Asn Gly Thr Trp Thr Gln Leu Trp Leu Val Ser Asp Tyr His Glu His 
        195                 200                 205             


Gly Ser Leu Phe Asp Tyr Leu Asn Arg Tyr Thr Val Thr Val Glu Gly 
    210                 215                 220                 


Met Ile Lys Leu Ala Leu Ser Thr Ala Ser Gly Leu Ala His Leu His 
225                 230                 235                 240 


Met Glu Ile Val Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp 
                245                 250                 255     


Leu Lys Ser Lys Asn Ile Leu Val Lys Lys Asn Gly Thr Cys Cys Ile 
            260                 265                 270         


Ala Asp Leu Gly Leu Ala Val Arg His Asp Ser Ala Thr Asp Thr Ile 
        275                 280                 285             


Asp Ile Ala Pro Asn His Arg Val Gly Thr Lys Arg Tyr Met Ala Pro 
    290                 295                 300                 


Glu Val Leu Asp Asp Ser Ile Asn Met Lys His Phe Glu Ser Phe Lys 
305                 310                 315                 320 


Arg Ala Asp Ile Tyr Ala Met Gly Leu Val Phe Trp Glu Ile Ala Arg 
                325                 330                 335     


Arg Cys Ser Ile Gly Gly Ile His Glu Asp Tyr Gln Leu Pro Tyr Tyr 
            340                 345                 350         


Asp Leu Val Pro Ser Asp Pro Ser Val Glu Glu Met Arg Lys Val Val 
        355                 360                 365             


Cys Glu Gln Lys Leu Arg Pro Asn Ile Pro Asn Arg Trp Gln Ser Cys 
    370                 375                 380                 


Glu Ala Leu Arg Val Met Ala Lys Ile Met Arg Glu Cys Trp Tyr Ala 
385                 390                 395                 400 


Asn Gly Ala Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Ser 
                405                 410                 415     


Gln Leu Ser Gln Gln Glu Gly Ile Lys Met 
            420                 425     


<210>  1448
<211>  666
<212>  PRT
<213>  Homo sapiens

<400>  1448

Met Glu Gly Val Ser Ala Leu Leu Ala Arg Cys Pro Thr Ala Gly Leu 
1               5                   10                  15      


Ala Gly Gly Leu Gly Val Thr Ala Cys Ala Ala Ala Gly Val Leu Leu 
            20                  25                  30          


Tyr Arg Ile Ala Arg Arg Met Lys Pro Thr His Thr Met Val Asn Cys 
        35                  40                  45              


Trp Phe Cys Asn Gln Asp Thr Leu Val Pro Tyr Gly Asn Arg Asn Cys 
    50                  55                  60                  


Trp Asp Cys Pro His Cys Glu Gln Tyr Asn Gly Phe Gln Glu Asn Gly 
65                  70                  75                  80  


Asp Tyr Asn Lys Pro Ile Pro Ala Gln Tyr Leu Glu His Leu Asn His 
                85                  90                  95      


Val Val Ser Ser Ala Pro Ser Leu Arg Asp Pro Ser Gln Pro Gln Gln 
            100                 105                 110         


Trp Val Ser Ser Gln Val Leu Leu Cys Lys Arg Cys Asn His His Gln 
        115                 120                 125             


Thr Thr Lys Ile Lys Gln Leu Ala Ala Phe Ala Pro Arg Glu Glu Gly 
    130                 135                 140                 


Arg Tyr Asp Glu Glu Val Glu Val Tyr Arg His His Leu Glu Gln Met 
145                 150                 155                 160 


Tyr Lys Leu Cys Arg Pro Cys Gln Ala Ala Val Glu Tyr Tyr Ile Lys 
                165                 170                 175     


His Gln Asn Arg Gln Leu Arg Ala Leu Leu Leu Ser His Gln Phe Lys 
            180                 185                 190         


Arg Arg Glu Ala Asp Gln Thr His Ala Gln Asn Phe Ser Ser Ala Val 
        195                 200                 205             


Lys Ser Pro Val Gln Val Ile Leu Leu Arg Ala Leu Ala Phe Leu Ala 
    210                 215                 220                 


Cys Ala Phe Leu Leu Thr Thr Ala Leu Tyr Gly Ala Ser Gly His Phe 
225                 230                 235                 240 


Ala Pro Gly Thr Thr Val Pro Leu Ala Leu Pro Pro Gly Gly Asn Gly 
                245                 250                 255     


Ser Ala Thr Pro Asp Asn Gly Thr Thr Pro Gly Ala Glu Gly Trp Arg 
            260                 265                 270         


Gln Leu Leu Gly Leu Leu Pro Glu His Met Ala Glu Lys Leu Cys Glu 
        275                 280                 285             


Ala Trp Ala Phe Gly Gln Ser His Gln Thr Gly Val Val Ala Leu Gly 
    290                 295                 300                 


Leu Leu Thr Cys Leu Leu Ala Met Leu Leu Ala Gly Arg Ile Arg Leu 
305                 310                 315                 320 


Arg Arg Ile Asp Ala Phe Cys Thr Cys Leu Trp Ala Leu Leu Leu Gly 
                325                 330                 335     


Leu His Leu Ala Glu Gln His Leu Gln Ala Ala Ser Pro Ser Trp Leu 
            340                 345                 350         


Asp Thr Leu Lys Phe Ser Thr Thr Ser Leu Cys Cys Leu Val Gly Phe 
        355                 360                 365             


Thr Ala Ala Val Ala Thr Arg Lys Ala Thr Gly Pro Arg Arg Phe Arg 
    370                 375                 380                 


Pro Arg Arg Phe Phe Pro Gly Asp Ser Ala Gly Leu Phe Pro Thr Ser 
385                 390                 395                 400 


Pro Ser Leu Ala Ile Pro His Pro Ser Val Gly Gly Ser Pro Ala Ser 
                405                 410                 415     


Leu Phe Ile Pro Ser Pro Pro Ser Phe Leu Pro Leu Ala Asn Gln Gln 
            420                 425                 430         


Leu Phe Arg Ser Pro Arg Arg Thr Ser Pro Ser Ser Leu Pro Gly Arg 
        435                 440                 445             


Leu Ser Arg Ala Leu Ser Leu Gly Thr Ile Pro Ser Leu Thr Arg Ala 
    450                 455                 460                 


Asp Ser Gly Tyr Leu Phe Ser Gly Ser Arg Pro Pro Ser Gln Val Ser 
465                 470                 475                 480 


Arg Ser Gly Glu Phe Pro Val Ser Asp Tyr Phe Ser Leu Leu Ser Gly 
                485                 490                 495     


Ser Cys Pro Ser Ser Pro Leu Pro Ser Pro Ala Pro Ser Val Ala Gly 
            500                 505                 510         


Ser Val Ala Ser Ser Ser Gly Ser Leu Arg His Arg Arg Pro Leu Ile 
        515                 520                 525             


Ser Pro Ala Arg Leu Asn Leu Lys Gly Gln Lys Leu Leu Leu Phe Pro 
    530                 535                 540                 


Ser Pro Pro Gly Glu Ala Pro Thr Thr Pro Ser Ser Ser Asp Glu His 
545                 550                 555                 560 


Ser Pro His Asn Gly Ser Leu Phe Thr Met Glu Pro Pro His Val Pro 
                565                 570                 575     


Arg Lys Pro Pro Leu Gln Asp Val Lys His Ala Leu Asp Leu Arg Ser 
            580                 585                 590         


Lys Leu Glu Arg Gly Ser Ala Cys Ser Asn Arg Ser Ile Lys Lys Glu 
        595                 600                 605             


Asp Asp Ser Ser Gln Ser Ser Thr Cys Val Val Asp Thr Thr Thr Arg 
    610                 615                 620                 


Gly Cys Ser Glu Glu Ala Ala Thr Trp Arg Gly Arg Phe Gly Pro Ser 
625                 630                 635                 640 


Leu Val Arg Gly Leu Leu Ala Val Ser Leu Ala Ala Asn Ala Leu Phe 
                645                 650                 655     


Thr Ser Val Phe Leu Tyr Gln Ser Leu Arg 
            660                 665     


<210>  1449
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  1449

Met Ala Leu Pro Tyr His Ile Phe Leu Phe Thr Val Leu Leu Pro Ser 
1               5                   10                  15      


Phe Thr Leu Thr Ala Pro Pro Pro Cys Arg Cys Met Thr Ser Ser Ser 
            20                  25                  30          


Pro Tyr Gln Glu Phe Leu Trp Arg Met Gln Arg Pro Gly Asn Ile Asp 
        35                  40                  45              


Ala Pro Ser Tyr Arg Ser Leu Ser Lys Gly Thr Pro Thr Phe Thr Ala 
    50                  55                  60                  


His Thr His Met Pro Arg Asn Cys Tyr His Ser Ala Thr Leu Cys Met 
65                  70                  75                  80  


His Ala Asn Thr His Tyr Trp Thr Gly Lys Met Ile Asn Pro Ser Cys 
                85                  90                  95      


Pro Gly Gly Leu Gly Val Thr Val Cys Trp Thr Tyr Phe Thr Gln Thr 
            100                 105                 110         


Gly Met Ser Asp Gly Gly Gly Val Gln Asp Gln Ala Arg Glu Lys His 
        115                 120                 125             


Val Lys Glu Val Ile Ser Gln Leu Thr Arg Val His Gly Thr Ser Ser 
    130                 135                 140                 


Pro Tyr Lys Gly Leu Asp Leu Ser Lys Leu His Glu Thr Leu Arg Thr 
145                 150                 155                 160 


His Thr Arg Leu Val Ser Leu Phe Asn Thr Thr Leu Thr Gly Leu His 
                165                 170                 175     


Glu Val Ser Ala Gln Asn Pro Thr Asn Cys Trp Ile Cys Leu Pro Leu 
            180                 185                 190         


Asn Phe Arg Pro Tyr Val Ser Ile Pro Val Pro Glu Gln Trp Asn Asn 
        195                 200                 205             


Phe Ser Thr Glu Ile Asn Thr Thr Ser Val Leu Val Gly Pro Leu Val 
    210                 215                 220                 


Ser Asn Leu Glu Ile Thr His Thr Ser Asn Leu Thr Cys Val Lys Phe 
225                 230                 235                 240 


Ser Asn Thr Thr Tyr Thr Thr Asn Ser Gln Cys Ile Arg Trp Val Thr 
                245                 250                 255     


Pro Pro Thr Gln Ile Val Cys Leu Pro Ser Gly Ile Phe Phe Val Cys 
            260                 265                 270         


Gly Thr Ser Ala Tyr Arg Cys Leu Asn Gly Ser Ser Glu Ser Met Cys 
        275                 280                 285             


Phe Leu Ser Phe Leu Val Pro Pro Met Thr Ile Tyr Thr Glu Gln Asp 
    290                 295                 300                 


Leu Tyr Ser Tyr Val Ile Ser Lys Pro Arg Asn Lys Arg Val Pro Ile 
305                 310                 315                 320 


Leu Pro Phe Val Ile Gly Ala Gly Val Leu Gly Ala Leu Gly Thr Gly 
                325                 330                 335     


Ile Gly Gly Ile Thr Thr Ser Thr Gln Phe Tyr Tyr Lys Leu Ser Gln 
            340                 345                 350         


Glu Leu Asn Gly Asp Met Glu Arg Val Ala Asp Ser Leu Val Thr Leu 
        355                 360                 365             


Gln Asp Gln Leu Asn Ser Leu Ala Ala Val Val Leu Gln Asn Arg Arg 
    370                 375                 380                 


Ala Leu Asp Leu Leu Thr Ala Glu Arg Gly Gly Thr Cys Leu Phe Leu 
385                 390                 395                 400 


Gly Glu Glu Cys Cys Tyr Tyr Val Asn Gln Ser Gly Ile Val Thr Glu 
                405                 410                 415     


Lys Val Lys Glu Ile Arg Asp Arg Ile Gln Arg Arg Ala Glu Glu Leu 
            420                 425                 430         


Arg Asn Thr Gly Pro Trp Gly Leu Leu Ser Gln Trp Met Pro Trp Ile 
        435                 440                 445             


Leu Pro Phe Leu Gly Pro Leu Ala Ala Ile Ile Leu Leu Leu Leu Phe 
    450                 455                 460                 


Gly Pro Cys Ile Phe Asn Leu Leu Val Asn Phe Val Ser Ser Arg Ile 
465                 470                 475                 480 


Glu Ala Val Lys Leu Gln Met Glu Pro Lys Met Gln Ser Lys Thr Lys 
                485                 490                 495     


Ile Tyr Arg Arg Pro Leu Asp Arg Pro Ala Ser Pro Arg Ser Asp Val 
            500                 505                 510         


Asn Asp Ile Lys Gly Thr Pro Pro Glu Glu Ile Ser Ala Ala Gln Pro 
        515                 520                 525             


Leu Leu Arg Pro Asn Ser Ala Gly Ser Ser 
    530                 535             


<210>  1450
<211>  951
<212>  PRT
<213>  Homo sapiens

<400>  1450

Met Ser Ala Arg Glu Val Ala Val Leu Leu Leu Trp Leu Ser Cys Tyr 
1               5                   10                  15      


Gly Ser Ala Leu Trp Arg Tyr Ser Thr Asn Ser Pro Asn Tyr Arg Ile 
            20                  25                  30          


Phe Ser Thr Arg Ser Thr Ile Lys Leu Glu Tyr Glu Gly Thr Leu Phe 
        35                  40                  45              


Thr Glu Trp Ser Val Pro Glu Thr Cys Phe Val Leu Asn Lys Ser Ser 
    50                  55                  60                  


Pro Thr Thr Glu Leu Arg Cys Ser Ser Pro Gly Val His Ala Ile Lys 
65                  70                  75                  80  


Pro Ile Val Thr Gly Pro Asp Glu Glu Glu Arg Tyr Leu Phe Val Glu 
                85                  90                  95      


Ser Ser His Thr Cys Phe Leu Trp Tyr Tyr Arg Val Arg His Phe Phe 
            100                 105                 110         


Asn Asn Phe Thr Gln Leu Ile Thr Val Trp Ala Tyr Asp Pro Glu Ser 
        115                 120                 125             


Ala Asp Pro Asp Glu Leu Leu Gly Asn Ala Glu Glu Pro Ser Ile Asn 
    130                 135                 140                 


Ser Ile Val Leu Ser Thr Gln Met Ala Thr Leu Gly Gln Lys Pro Val 
145                 150                 155                 160 


Ile His Thr Val Leu Lys Arg Lys Val Tyr Ser Ser Asn Glu Lys Met 
                165                 170                 175     


Arg Arg Gly Thr Trp Arg Ile Val Val Pro Met Thr Lys Asp Asp Ala 
            180                 185                 190         


Leu Lys Glu Ile Arg Gly Asn Gln Val Thr Phe Gln Asp Cys Phe Ile 
        195                 200                 205             


Ala Asp Phe Leu Ile Leu Leu Thr Phe Pro Leu Leu Thr Ile Pro Glu 
    210                 215                 220                 


Ile Pro Gly Tyr Leu Pro Ile Ser Ser Pro Arg Gly Ser Gln Leu Met 
225                 230                 235                 240 


Ala Ser Trp Asp Ala Cys Val Val Ala Ser Ala Val Leu Val Thr Asp 
                245                 250                 255     


Met Glu Thr Phe His Thr Thr Asp Ser Phe Lys Ser Trp Thr Arg Ile 
            260                 265                 270         


Arg Val Pro Pro Asp Ile Leu Ser Asp Asp Glu Arg Arg Ser Val Ala 
        275                 280                 285             


His Val Ile Leu Ser Arg Asp Gly Ile Val Phe Leu Ile Asn Gly Val 
    290                 295                 300                 


Leu Tyr Ile Lys Ser Phe Arg Gly Phe Ile Arg Leu Gly Gly Ile Val 
305                 310                 315                 320 


Asn Leu Pro Asp Gly Gly Ile Thr Gly Ile Ser Ser Arg Lys Trp Cys 
                325                 330                 335     


Trp Val Asn Tyr Leu Leu Lys Ala Lys Gly Arg Arg Ser Thr Phe Ala 
            340                 345                 350         


Val Trp Thr Glu Asn Glu Ile Tyr Leu Gly Ser Ile Leu Leu Lys Phe 
        355                 360                 365             


Ala Arg Leu Val Thr Thr Thr Glu Leu Lys Asn Ile Leu Ser Leu Ser 
    370                 375                 380                 


Val Thr Ala Thr Leu Thr Ile Asp Arg Val Glu Tyr Thr Gly His Pro 
385                 390                 395                 400 


Leu Glu Ile Ala Val Phe Leu Asn Tyr Cys Thr Val Cys Asn Val Thr 
                405                 410                 415     


Lys Lys Ile Phe Leu Val Ile Tyr Asn Glu Asp Thr Lys Gln Trp Val 
            420                 425                 430         


Ser Gln Asp Phe Thr Leu Asp Ala Pro Ile Asp Ser Val Thr Met Pro 
        435                 440                 445             


His Phe Thr Phe Ser Ala Leu Pro Gly Leu Leu Leu Trp Asn Lys His 
    450                 455                 460                 


Ser Ile Tyr Tyr Cys Tyr His Asn Phe Thr Phe Thr Gly Ile Leu Gln 
465                 470                 475                 480 


Thr Pro Ala Gly His Gly Asn Leu Ser Met Leu Ser Asn Asp Ser Ile 
                485                 490                 495     


Ile His Glu Val Phe Ile Asp Tyr Tyr Gly Asp Ile Leu Val Lys Met 
            500                 505                 510         


Glu Asn Asn Val Ile Phe Tyr Ser Lys Ile Asn Thr Arg Asp Ala Val 
        515                 520                 525             


Lys Leu His Leu Trp Thr Asn Tyr Thr Thr Arg Ala Phe Ile Phe Leu 
    530                 535                 540                 


Ser Thr Ser Gly Gln Thr Tyr Phe Leu Tyr Ala Leu Asp Asp Gly Thr 
545                 550                 555                 560 


Ile Gln Ile Gln Asp Tyr Pro Leu His Leu Glu Ala Gln Ser Ile Ala 
                565                 570                 575     


Phe Thr Thr Lys Asp Lys Cys Pro Tyr Met Ala Phe His Asn Asn Val 
            580                 585                 590         


Ala His Val Phe Tyr Phe Leu Asp Lys Gly Glu Ala Leu Thr Val Trp 
        595                 600                 605             


Thr Gln Ile Val Tyr Pro Glu Asn Thr Gly Leu Tyr Val Ile Val Glu 
    610                 615                 620                 


Ser Tyr Gly Pro Lys Ile Leu Gln Glu Ser His Glu Ile Ser Phe Glu 
625                 630                 635                 640 


Ala Ala Phe Gly Tyr Cys Thr Lys Thr Leu Thr Leu Thr Phe Tyr Gln 
                645                 650                 655     


Asn Val Asp Tyr Glu Arg Ile Ser Asp Tyr Phe Glu Thr Gln Asp Lys 
            660                 665                 670         


His Thr Gly Leu Val Leu Val Gln Phe Arg Pro Ser Glu Tyr Ser Lys 
        675                 680                 685             


Ala Cys Pro Ile Ala Gln Lys Val Phe Gln Ile Ala Val Gly Cys Asp 
    690                 695                 700                 


Asp Lys Lys Phe Ile Ala Ile Lys Gly Phe Ser Lys Lys Gly Cys His 
705                 710                 715                 720 


His His Asp Phe Ser Tyr Val Ile Glu Lys Ser Tyr Leu Arg His Gln 
                725                 730                 735     


Pro Ser Lys Asn Leu Arg Val Arg Tyr Ile Trp Gly Glu Tyr Gly Cys 
            740                 745                 750         


Pro Leu Arg Leu Asp Phe Thr Glu Lys Phe Gln Pro Val Val Gln Leu 
        755                 760                 765             


Phe Asp Asp Asn Gly Tyr Val Lys Asp Val Glu Ala Asn Phe Ile Val 
    770                 775                 780                 


Trp Glu Ile His Gly Arg Asp Asp Tyr Ser Phe Asn Asn Thr Met Ala 
785                 790                 795                 800 


Gln Ser Gly Cys Leu His Glu Ala Gln Thr Trp Lys Ser Met Ile Glu 
                805                 810                 815     


Leu Asn Lys His Leu Pro Leu Glu Glu Val Trp Gly Pro Glu Asn Tyr 
            820                 825                 830         


Lys His Cys Phe Ser Tyr Ala Ile Gly Lys Pro Gly Asp Leu Asn Gln 
        835                 840                 845             


Pro Tyr Glu Ile Ile Asn Ser Ser Asn Gly Asn His Ile Phe Trp Pro 
    850                 855                 860                 


Met Gly His Ser Gly Met Tyr Val Phe Arg Val Lys Ile Leu Asp Pro 
865                 870                 875                 880 


Asn Tyr Ser Phe Cys Asn Leu Thr Ala Met Phe Ala Ile Glu Thr Phe 
                885                 890                 895     


Gly Leu Ile Pro Ser Pro Ser Val Tyr Leu Val Ala Ser Phe Leu Phe 
            900                 905                 910         


Val Leu Met Leu Leu Phe Phe Thr Ile Leu Val Leu Ser Tyr Phe Arg 
        915                 920                 925             


Tyr Met Arg Ile Tyr Arg Arg Tyr Ile Tyr Glu Pro Leu His Lys Pro 
    930                 935                 940                 


Gln Arg Lys Arg Lys Lys Asn 
945                 950     


<210>  1451
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  1451

Met Ala Gly Gly Met Lys Val Ala Val Ser Pro Ala Val Gly Pro Gly 
1               5                   10                  15      


Pro Trp Gly Ser Gly Val Gly Gly Gly Gly Thr Val Arg Leu Leu Leu 
            20                  25                  30          


Ile Leu Ser Gly Cys Leu Val Tyr Gly Thr Ala Glu Thr Asp Val Asn 
        35                  40                  45              


Val Val Met Leu Gln Glu Ser Gln Val Cys Glu Lys Arg Ala Ser Gln 
    50                  55                  60                  


Gln Phe Cys Tyr Thr Asn Val Leu Ile Pro Lys Trp His Asp Ile Trp 
65                  70                  75                  80  


Thr Arg Ile Gln Ile Arg Val Asn Ser Ser Arg Leu Val Arg Val Thr 
                85                  90                  95      


Gln Val Glu Asn Glu Glu Lys Leu Lys Glu Leu Glu Gln Phe Ser Ile 
            100                 105                 110         


Trp Asn Phe Phe Ser Ser Phe Leu Lys Glu Lys Leu Asn Asp Thr Tyr 
        115                 120                 125             


Val Asn Val Gly Leu Tyr Ser Thr Lys Thr Cys Leu Lys Val Glu Ile 
    130                 135                 140                 


Ile Glu Lys Asp Thr Lys Tyr Ser Val Ile Val Ile Arg Arg Phe Asp 
145                 150                 155                 160 


Pro Lys Leu Phe Leu Val Phe Leu Leu Gly Leu Met Leu Phe Phe Cys 
                165                 170                 175     


Gly Asp Leu Leu Ser Arg Ser Gln Ile Phe Tyr Tyr Ser Thr Gly Met 
            180                 185                 190         


Thr Val Gly Ile Val Ala Ser Leu Leu Ile Ile Ile Phe Ile Leu Ser 
        195                 200                 205             


Lys Phe Met Pro Lys Lys Ser Pro Ile Tyr Val Ile Leu Val Gly Gly 
    210                 215                 220                 


Trp Ser Phe Ser Leu Tyr Leu Ile Gln Leu Val Phe Lys Asn Leu Gln 
225                 230                 235                 240 


Glu Ile Trp Arg Cys Tyr Trp Gln Tyr Leu Leu Ser Tyr Val Leu Thr 
                245                 250                 255     


Val Gly Phe Met Ser Phe Ala Val Cys Tyr Lys Tyr Gly Pro Leu Glu 
            260                 265                 270         


Asn Glu Arg Ser Ile Asn Leu Leu Thr Trp Thr Leu Gln Leu Met Gly 
        275                 280                 285             


Leu Cys Phe Met Tyr Ser Gly Ile Gln Ile Pro His Ile Ala Leu Ala 
    290                 295                 300                 


Ile Ile Ile Ile Ala Leu Cys Thr Lys Asn Leu Glu His Pro Ile Gln 
305                 310                 315                 320 


Trp Leu Tyr Ile Thr Cys Arg Lys Val Cys Lys Gly Ala Glu Lys Pro 
                325                 330                 335     


Val Pro Pro Arg Leu Leu Thr Glu Glu Glu Tyr Arg Ile Gln Gly Glu 
            340                 345                 350         


Val Glu Thr Arg Lys Ala Leu Glu Glu Leu Arg Glu Phe Cys Asn Ser 
        355                 360                 365             


Pro Asp Cys Ser Ala Trp Lys Thr Val Ser Arg Ile Gln Ser Pro Lys 
    370                 375                 380                 


Arg Phe Ala Asp Phe Val Glu Gly Ser Ser His Leu Thr Pro Asn Glu 
385                 390                 395                 400 


Val Ser Val His Glu Gln Glu Tyr Gly Leu Gly Ser Ile Ile Ala Gln 
                405                 410                 415     


Asp Glu Ile Tyr Glu Glu Ala Ser Ser Glu Glu Glu Asp Ser Tyr Ser 
            420                 425                 430         


Arg Cys Pro Ala Ile Thr Gln Asn Asn Phe Leu Thr 
        435                 440                 


<210>  1452
<211>  785
<212>  PRT
<213>  Homo sapiens

<400>  1452

Met Asp Phe Ser Arg Leu His Met Tyr Ser Pro Pro Gln Cys Val Pro 
1               5                   10                  15      


Glu Asn Thr Gly Tyr Thr Tyr Ala Leu Ser Ser Ser Tyr Ser Ser Asp 
            20                  25                  30          


Ala Leu Asp Phe Glu Thr Glu His Lys Leu Asp Pro Val Phe Asp Ser 
        35                  40                  45              


Pro Arg Met Ser Arg Arg Ser Leu Arg Leu Ala Thr Thr Ala Cys Thr 
    50                  55                  60                  


Leu Gly Asp Gly Glu Ala Val Gly Ala Asp Ser Gly Thr Ser Ser Ala 
65                  70                  75                  80  


Val Ser Leu Lys Asn Arg Ala Ala Arg Thr Thr Lys Gln Arg Arg Ser 
                85                  90                  95      


Thr Asn Lys Ser Ala Phe Ser Ile Asn His Val Ser Arg Gln Val Thr 
            100                 105                 110         


Ser Ser Gly Val Ser His Gly Gly Thr Val Ser Leu Gln Asp Ala Val 
        115                 120                 125             


Thr Arg Arg Pro Pro Val Leu Asp Glu Ser Trp Ile Arg Glu Gln Thr 
    130                 135                 140                 


Thr Val Asp His Phe Trp Gly Leu Asp Asp Asp Gly Asp Leu Lys Gly 
145                 150                 155                 160 


Gly Asn Lys Ala Ala Ile Gln Gly Asn Gly Asp Val Gly Ala Ala Ala 
                165                 170                 175     


Ala Thr Ala His Asn Gly Phe Ser Cys Ser Asn Cys Ser Met Leu Ser 
            180                 185                 190         


Glu Arg Lys Asp Val Leu Thr Ala His Pro Ala Ala Pro Gly Pro Val 
        195                 200                 205             


Ser Arg Val Tyr Ser Arg Asp Arg Asn Gln Lys Cys Tyr Phe Leu Leu 
    210                 215                 220                 


Gln Ile Leu Arg Arg Ile Gly Ala Val Gly Gln Ala Val Ser Arg Thr 
225                 230                 235                 240 


Ala Trp Ser Ala Leu Trp Leu Ala Val Val Ala Pro Gly Lys Ala Ala 
                245                 250                 255     


Ser Gly Val Phe Trp Trp Leu Gly Ile Gly Trp Tyr Gln Phe Val Thr 
            260                 265                 270         


Leu Ile Ser Trp Leu Asn Val Phe Leu Leu Thr Arg Cys Leu Arg Asn 
        275                 280                 285             


Ile Cys Lys Phe Leu Val Leu Leu Ile Pro Leu Phe Leu Leu Leu Ala 
    290                 295                 300                 


Gly Leu Ser Leu Arg Gly Gln Gly Asn Phe Phe Ser Phe Leu Pro Val 
305                 310                 315                 320 


Leu Asn Trp Ala Ser Met His Arg Thr Gln Arg Val Asp Asp Pro Gln 
                325                 330                 335     


Asp Val Phe Lys Pro Thr Thr Ser Arg Leu Lys Gln Pro Leu Gln Gly 
            340                 345                 350         


Asp Ser Glu Ala Phe Pro Trp His Trp Met Ser Gly Val Glu Gln Gln 
        355                 360                 365             


Val Ala Ser Leu Ser Gly Gln Cys His His His Gly Glu Asn Leu Arg 
    370                 375                 380                 


Glu Leu Thr Thr Leu Leu Gln Lys Leu Gln Ala Arg Val Asp Gln Met 
385                 390                 395                 400 


Glu Gly Gly Ala Ala Gly Pro Ser Ala Ser Val Arg Asp Ala Val Gly 
                405                 410                 415     


Gln Pro Pro Arg Glu Thr Asp Phe Met Ala Phe His Gln Glu His Glu 
            420                 425                 430         


Val Arg Met Ser His Leu Glu Asp Ile Leu Gly Lys Leu Arg Glu Lys 
        435                 440                 445             


Ser Glu Ala Ile Gln Lys Glu Leu Glu Gln Thr Lys Gln Lys Thr Ile 
    450                 455                 460                 


Ser Ala Val Gly Glu Gln Leu Leu Pro Thr Val Glu His Leu Gln Leu 
465                 470                 475                 480 


Glu Leu Asp Gln Leu Lys Ser Glu Leu Ser Ser Trp Arg His Val Lys 
                485                 490                 495     


Thr Gly Cys Glu Thr Val Asp Ala Val Gln Glu Arg Val Asp Val Gln 
            500                 505                 510         


Val Arg Glu Met Val Lys Leu Leu Phe Ser Glu Asp Gln Gln Gly Gly 
        515                 520                 525             


Ser Leu Glu Gln Leu Leu Gln Arg Phe Ser Ser Gln Phe Val Ser Lys 
    530                 535                 540                 


Gly Asp Leu Gln Thr Met Leu Arg Asp Leu Gln Leu Gln Ile Leu Arg 
545                 550                 555                 560 


Asn Val Thr His His Val Ser Val Thr Lys Gln Leu Pro Thr Ser Glu 
                565                 570                 575     


Ala Val Val Ser Ala Val Ser Glu Ala Gly Ala Ser Gly Ile Thr Glu 
            580                 585                 590         


Ala Gln Ala Arg Ala Ile Val Asn Ser Ala Leu Lys Leu Tyr Ser Gln 
        595                 600                 605             


Asp Lys Thr Gly Met Val Asp Phe Ala Leu Glu Ser Gly Gly Gly Ser 
    610                 615                 620                 


Ile Leu Ser Thr Arg Cys Ser Glu Thr Tyr Glu Thr Lys Thr Ala Leu 
625                 630                 635                 640 


Met Ser Leu Phe Gly Ile Pro Leu Trp Tyr Phe Ser Gln Ser Pro Arg 
                645                 650                 655     


Val Val Ile Gln Pro Asp Ile Tyr Pro Gly Asn Cys Trp Ala Phe Lys 
            660                 665                 670         


Gly Ser Gln Gly Tyr Leu Val Val Arg Leu Ser Met Met Ile His Pro 
        675                 680                 685             


Ala Ala Phe Thr Leu Glu His Ile Pro Lys Thr Leu Ser Pro Thr Gly 
    690                 695                 700                 


Asn Ile Ser Ser Ala Pro Lys Asp Phe Ala Val Tyr Gly Leu Glu Asn 
705                 710                 715                 720 


Glu Tyr Gln Glu Glu Gly Gln Leu Leu Gly Gln Phe Thr Tyr Asp Gln 
                725                 730                 735     


Asp Gly Glu Ser Leu Gln Met Phe Gln Ala Leu Lys Arg Pro Asp Asp 
            740                 745                 750         


Thr Ala Phe Gln Ile Val Glu Leu Arg Ile Phe Ser Asn Trp Gly His 
        755                 760                 765             


Pro Glu Tyr Thr Cys Leu Tyr Arg Phe Arg Val His Gly Glu Pro Val 
    770                 775                 780                 


Lys 
785 


<210>  1453
<211>  2066
<212>  PRT
<213>  Homo sapiens

<400>  1453

Met Leu Arg Val Phe Ile Leu Tyr Ala Glu Asn Val His Thr Pro Asp 
1               5                   10                  15      


Thr Asp Ile Ser Asp Ala Tyr Cys Ser Ala Val Phe Ala Gly Val Lys 
            20                  25                  30          


Lys Arg Thr Lys Val Ile Lys Asn Ser Val Asn Pro Val Trp Asn Glu 
        35                  40                  45              


Gly Phe Glu Trp Asp Leu Lys Gly Ile Pro Leu Asp Gln Gly Ser Glu 
    50                  55                  60                  


Leu His Val Val Val Lys Asp His Glu Thr Met Gly Arg Asn Arg Phe 
65                  70                  75                  80  


Leu Gly Glu Ala Lys Val Pro Leu Arg Glu Val Leu Ala Thr Pro Ser 
                85                  90                  95      


Leu Ser Ala Ser Phe Asn Ala Pro Leu Leu Asp Thr Lys Lys Gln Pro 
            100                 105                 110         


Thr Gly Ala Ser Leu Val Leu Gln Val Ser Tyr Thr Pro Leu Pro Gly 
        115                 120                 125             


Ala Val Pro Leu Phe Pro Pro Pro Thr Pro Leu Glu Pro Ser Pro Thr 
    130                 135                 140                 


Leu Pro Asp Leu Asp Val Val Ala Asp Thr Gly Gly Glu Glu Asp Thr 
145                 150                 155                 160 


Glu Asp Gln Gly Leu Thr Gly Asp Glu Ala Glu Pro Phe Leu Asp Gln 
                165                 170                 175     


Ser Gly Gly Pro Gly Ala Pro Thr Thr Pro Arg Lys Leu Pro Ser Arg 
            180                 185                 190         


Pro Pro Pro His Tyr Pro Gly Ile Lys Arg Lys Arg Ser Ala Pro Thr 
        195                 200                 205             


Ser Arg Lys Leu Leu Ser Asp Lys Pro Gln Asp Phe Gln Ile Arg Val 
    210                 215                 220                 


Gln Val Ile Glu Gly Arg Gln Leu Pro Gly Val Asn Ile Lys Pro Val 
225                 230                 235                 240 


Val Lys Val Thr Ala Ala Gly Gln Thr Lys Arg Thr Arg Ile His Lys 
                245                 250                 255     


Gly Asn Ser Pro Leu Phe Asn Glu Thr Leu Phe Phe Asn Leu Phe Asp 
            260                 265                 270         


Ser Pro Gly Glu Leu Phe Asp Glu Pro Ile Phe Ile Thr Val Val Asp 
        275                 280                 285             


Ser Arg Ser Leu Arg Thr Asp Ala Leu Leu Gly Glu Phe Arg Met Asp 
    290                 295                 300                 


Val Gly Thr Ile Tyr Arg Glu Pro Arg His Ala Tyr Leu Arg Lys Trp 
305                 310                 315                 320 


Leu Leu Leu Ser Asp Pro Asp Asp Phe Ser Ala Gly Ala Arg Gly Tyr 
                325                 330                 335     


Leu Lys Thr Ser Leu Cys Val Leu Gly Pro Gly Asp Glu Ala Pro Leu 
            340                 345                 350         


Glu Arg Lys Asp Pro Ser Glu Asp Lys Glu Asp Ile Glu Ser Asn Leu 
        355                 360                 365             


Leu Arg Pro Thr Gly Val Ala Leu Arg Gly Ala His Phe Cys Leu Lys 
    370                 375                 380                 


Val Phe Arg Ala Glu Asp Leu Pro Gln Met Asp Asp Ala Val Met Asp 
385                 390                 395                 400 


Asn Val Lys Gln Ile Phe Gly Phe Glu Ser Asn Lys Lys Asn Leu Val 
                405                 410                 415     


Asp Pro Phe Val Glu Val Ser Phe Ala Gly Lys Met Leu Cys Ser Lys 
            420                 425                 430         


Ile Leu Glu Lys Thr Ala Asn Pro Gln Trp Asn Gln Asn Ile Thr Leu 
        435                 440                 445             


Pro Ala Met Phe Pro Ser Met Cys Glu Lys Met Arg Ile Arg Ile Ile 
    450                 455                 460                 


Asp Trp Asp Arg Leu Thr His Asn Asp Ile Val Ala Thr Thr Tyr Leu 
465                 470                 475                 480 


Ser Met Ser Lys Ile Ser Ala Pro Gly Gly Glu Ile Glu Val Asp Asp 
                485                 490                 495     


Tyr Leu Gly Phe Leu Pro Thr Phe Gly Pro Cys Tyr Ile Asn Leu Tyr 
            500                 505                 510         


Gly Ser Pro Arg Glu Phe Thr Gly Phe Pro Asp Pro Tyr Thr Glu Leu 
        515                 520                 525             


Asn Thr Gly Lys Gly Glu Gly Val Ala Tyr Arg Gly Arg Leu Leu Leu 
    530                 535                 540                 


Ser Leu Glu Thr Lys Leu Val Glu His Ser Glu Gln Lys Val Glu Asp 
545                 550                 555                 560 


Leu Pro Ala Asp Asp Ile Leu Arg Val Glu Lys Tyr Leu Arg Arg Arg 
                565                 570                 575     


Lys Tyr Ser Leu Phe Ala Ala Phe Tyr Ser Ala Thr Met Leu Gln Asp 
            580                 585                 590         


Val Asp Asp Ala Ile Gln Phe Glu Val Ser Ile Gly Asn Tyr Gly Asn 
        595                 600                 605             


Lys Phe Asp Met Thr Cys Leu Pro Leu Ala Ser Thr Thr Gln Tyr Ser 
    610                 615                 620                 


Arg Ala Val Phe Asp Gly Cys His Tyr Tyr Tyr Leu Pro Trp Gly Asn 
625                 630                 635                 640 


Val Lys Pro Val Val Val Leu Ser Ser Tyr Trp Glu Asp Ile Ser His 
                645                 650                 655     


Arg Ile Glu Thr Gln Asn Gln Leu Leu Gly Ile Ala Asp Arg Leu Glu 
            660                 665                 670         


Ala Gly Leu Glu Gln Val His Leu Ala Leu Lys Ala Gln Cys Ser Thr 
        675                 680                 685             


Glu Asp Val Asp Ser Leu Val Ala Gln Leu Thr Asp Glu Leu Ile Ala 
    690                 695                 700                 


Gly Cys Ser Gln Pro Leu Gly Asp Ile His Glu Thr Pro Ser Ala Thr 
705                 710                 715                 720 


His Leu Asp Gln Tyr Leu Tyr Gln Leu Arg Thr His His Leu Ser Gln 
                725                 730                 735     


Ile Thr Glu Ala Ala Leu Ala Leu Lys Leu Gly His Ser Glu Leu Pro 
            740                 745                 750         


Ala Ala Leu Glu Gln Ala Glu Asp Trp Leu Leu Arg Leu Arg Ala Leu 
        755                 760                 765             


Ala Glu Glu Pro Gln Asn Ser Leu Pro Asp Ile Val Ile Trp Met Leu 
    770                 775                 780                 


Gln Gly Asp Lys Arg Val Ala Tyr Gln Arg Val Pro Ala His Gln Val 
785                 790                 795                 800 


Leu Phe Ser Arg Arg Gly Ala Asn Tyr Cys Gly Lys Asn Cys Gly Lys 
                805                 810                 815     


Leu Gln Thr Ile Phe Leu Lys Tyr Pro Met Glu Lys Val Pro Gly Ala 
            820                 825                 830         


Arg Met Pro Val Gln Ile Arg Val Lys Leu Trp Phe Gly Leu Ser Val 
        835                 840                 845             


Asp Glu Lys Glu Phe Asn Gln Phe Ala Glu Gly Lys Leu Ser Val Phe 
    850                 855                 860                 


Ala Glu Thr Tyr Glu Asn Glu Thr Lys Leu Ala Leu Val Gly Asn Trp 
865                 870                 875                 880 


Gly Thr Thr Gly Leu Thr Tyr Pro Lys Phe Ser Asp Val Thr Gly Lys 
                885                 890                 895     


Ile Lys Leu Pro Lys Asp Ser Phe Arg Pro Ser Ala Gly Trp Thr Trp 
            900                 905                 910         


Ala Gly Asp Trp Phe Val Cys Pro Glu Lys Thr Leu Leu His Asp Met 
        915                 920                 925             


Asp Ala Gly His Leu Ser Phe Val Glu Glu Val Phe Glu Asn Gln Thr 
    930                 935                 940                 


Arg Leu Pro Gly Gly Gln Trp Ile Tyr Met Ser Asp Asn Tyr Thr Asp 
945                 950                 955                 960 


Val Asn Gly Glu Lys Val Leu Pro Lys Asp Asp Ile Glu Cys Pro Leu 
                965                 970                 975     


Gly Trp Lys Trp Glu Asp Glu Glu Trp Ser Thr Asp Leu Asn Arg Ala 
            980                 985                 990         


Val Asp Glu Gln Gly Trp Glu Tyr  Ser Ile Thr Ile Pro  Pro Glu Arg 
        995                 1000                 1005             


Lys Pro  Lys His Trp Val Pro  Ala Glu Lys Met Tyr  Tyr Thr His 
    1010                 1015                 1020             


Arg Arg  Arg Arg Trp Val Arg  Leu Arg Arg Arg Asp  Leu Ser Gln 
    1025                 1030                 1035             


Met Glu  Ala Leu Lys Arg His  Arg Gln Ala Glu Ala  Glu Gly Glu 
    1040                 1045                 1050             


Gly Trp  Glu Tyr Ala Ser Leu  Phe Gly Trp Lys Phe  His Leu Glu 
    1055                 1060                 1065             


Tyr Arg  Lys Thr Asp Ala Phe  Arg Arg Arg Arg Trp  Arg Arg Arg 
    1070                 1075                 1080             


Met Glu  Pro Leu Glu Lys Thr  Gly Pro Ala Ala Val  Phe Ala Leu 
    1085                 1090                 1095             


Glu Gly  Ala Leu Gly Gly Val  Met Asp Asp Lys Ser  Glu Asp Ser 
    1100                 1105                 1110             


Met Ser  Val Ser Thr Leu Ser  Phe Gly Val Asn Arg  Pro Thr Ile 
    1115                 1120                 1125             


Ser Cys  Ile Phe Asp Tyr Gly  Asn Arg Tyr His Leu  Arg Cys Tyr 
    1130                 1135                 1140             


Met Tyr  Gln Ala Arg Asp Leu  Ala Ala Met Asp Lys  Asp Ser Phe 
    1145                 1150                 1155             


Ser Asp  Pro Tyr Ala Ile Val  Ser Phe Leu His Gln  Ser Gln Lys 
    1160                 1165                 1170             


Thr Val  Val Val Lys Asn Thr  Leu Asn Pro Thr Trp  Asp Gln Thr 
    1175                 1180                 1185             


Leu Ile  Phe Tyr Glu Ile Glu  Ile Phe Gly Glu Pro  Ala Thr Val 
    1190                 1195                 1200             


Ala Glu  Gln Pro Pro Ser Ile  Val Val Glu Leu Tyr  Asp His Asp 
    1205                 1210                 1215             


Thr Tyr  Gly Ala Asp Glu Phe  Met Gly Arg Cys Ile  Cys Gln Pro 
    1220                 1225                 1230             


Ser Leu  Glu Arg Met Pro Arg  Leu Ala Trp Phe Pro  Leu Thr Arg 
    1235                 1240                 1245             


Gly Ser  Gln Pro Ser Gly Glu  Leu Leu Ala Ser Phe  Glu Leu Ile 
    1250                 1255                 1260             


Gln Arg  Glu Lys Pro Ala Ile  His His Ile Pro Gly  Phe Glu Val 
    1265                 1270                 1275             


Gln Glu  Thr Ser Arg Ile Leu  Asp Glu Ser Glu Asp  Thr Asp Leu 
    1280                 1285                 1290             


Pro Tyr  Pro Pro Pro Gln Arg  Glu Ala Asn Ile Tyr  Met Val Pro 
    1295                 1300                 1305             


Gln Asn  Ile Lys Pro Ala Leu  Gln Arg Thr Ala Ile  Glu Ile Leu 
    1310                 1315                 1320             


Ala Trp  Gly Leu Arg Asn Met  Lys Ser Tyr Gln Leu  Ala Asn Ile 
    1325                 1330                 1335             


Ser Ser  Pro Ser Leu Val Val  Glu Cys Gly Gly Gln  Thr Val Gln 
    1340                 1345                 1350             


Ser Cys  Val Ile Arg Asn Leu  Arg Lys Asn Pro Asn  Phe Asp Ile 
    1355                 1360                 1365             


Cys Thr  Leu Phe Met Glu Val  Met Leu Pro Arg Glu  Glu Leu Tyr 
    1370                 1375                 1380             


Cys Pro  Pro Ile Thr Val Lys  Val Ile Asp Asn Arg  Gln Phe Gly 
    1385                 1390                 1395             


Arg Arg  Pro Val Val Gly Gln  Cys Thr Ile Arg Ser  Leu Glu Ser 
    1400                 1405                 1410             


Phe Leu  Cys Asp Pro Tyr Ser  Ala Glu Ser Pro Ser  Pro Gln Gly 
    1415                 1420                 1425             


Gly Pro  Asp Asp Val Ser Leu  Leu Ser Pro Gly Glu  Asp Val Leu 
    1430                 1435                 1440             


Ile Asp  Ile Asp Asp Lys Glu  Pro Leu Ile Pro Ile  Gln Glu Glu 
    1445                 1450                 1455             


Glu Phe  Ile Asp Trp Trp Ser  Lys Phe Phe Ala Ser  Ile Gly Glu 
    1460                 1465                 1470             


Arg Glu  Lys Cys Gly Ser Tyr  Leu Glu Lys Asp Phe  Asp Thr Leu 
    1475                 1480                 1485             


Lys Val  Tyr Asp Thr Gln Leu  Glu Asn Val Glu Ala  Phe Glu Gly 
    1490                 1495                 1500             


Leu Ser  Asp Phe Cys Asn Thr  Phe Lys Leu Tyr Arg  Gly Lys Thr 
    1505                 1510                 1515             


Gln Glu  Glu Thr Glu Asp Pro  Ser Val Ile Gly Glu  Phe Lys Gly 
    1520                 1525                 1530             


Leu Phe  Lys Ile Tyr Pro Leu  Pro Glu Asp Pro Ala  Ile Pro Met 
    1535                 1540                 1545             


Pro Pro  Arg Gln Phe His Gln  Leu Ala Ala Gln Gly  Pro Gln Glu 
    1550                 1555                 1560             


Cys Leu  Val Arg Ile Tyr Ile  Val Arg Ala Phe Gly  Leu Gln Pro 
    1565                 1570                 1575             


Lys Asp  Pro Asn Gly Lys Cys  Asp Pro Tyr Ile Lys  Ile Ser Ile 
    1580                 1585                 1590             


Gly Lys  Lys Ser Val Ser Asp  Gln Asp Asn Tyr Ile  Pro Cys Thr 
    1595                 1600                 1605             


Leu Glu  Pro Val Phe Gly Lys  Met Phe Glu Leu Thr  Cys Thr Leu 
    1610                 1615                 1620             


Pro Leu  Glu Lys Asp Leu Lys  Ile Thr Leu Tyr Asp  Tyr Asp Leu 
    1625                 1630                 1635             


Leu Ser  Lys Asp Glu Lys Ile  Gly Glu Thr Val Val  Asp Leu Glu 
    1640                 1645                 1650             


Asn Arg  Leu Leu Ser Lys Phe  Gly Ala Arg Cys Gly  Leu Pro Gln 
    1655                 1660                 1665             


Thr Tyr  Cys Val Ser Gly Pro  Asn Gln Trp Arg Asp  Gln Leu Arg 
    1670                 1675                 1680             


Pro Ser  Gln Leu Leu His Leu  Phe Cys Gln Gln His  Arg Val Lys 
    1685                 1690                 1695             


Ala Pro  Val Tyr Arg Thr Asp  Arg Val Met Phe Gln  Asp Lys Glu 
    1700                 1705                 1710             


Tyr Ser  Ile Glu Glu Ile Glu  Ala Gly Arg Ile Pro  Asn Pro His 
    1715                 1720                 1725             


Leu Gly  Pro Val Glu Glu Arg  Leu Ala Leu His Val  Leu Gln Gln 
    1730                 1735                 1740             


Gln Gly  Leu Val Pro Glu His  Val Glu Ser Arg Pro  Leu Tyr Ser 
    1745                 1750                 1755             


Pro Leu  Gln Pro Asp Ile Glu  Gln Gly Lys Leu Gln  Met Trp Val 
    1760                 1765                 1770             


Asp Leu  Phe Pro Lys Ala Leu  Gly Arg Pro Gly Pro  Pro Phe Asn 
    1775                 1780                 1785             


Ile Thr  Pro Arg Arg Ala Arg  Arg Phe Phe Leu Arg  Cys Ile Ile 
    1790                 1795                 1800             


Trp Asn  Thr Arg Asp Val Ile  Leu Asp Asp Leu Ser  Leu Thr Gly 
    1805                 1810                 1815             


Glu Lys  Met Ser Asp Ile Tyr  Val Lys Gly Trp Met  Ile Gly Phe 
    1820                 1825                 1830             


Glu Glu  His Lys Gln Lys Thr  Asp Val His Tyr Arg  Ser Leu Gly 
    1835                 1840                 1845             


Gly Glu  Gly Asn Phe Asn Trp  Arg Phe Ile Phe Pro  Phe Asp Tyr 
    1850                 1855                 1860             


Leu Pro  Ala Glu Gln Val Cys  Thr Ile Ala Lys Lys  Asp Ala Phe 
    1865                 1870                 1875             


Trp Arg  Leu Asp Lys Thr Glu  Ser Lys Ile Pro Ala  Arg Val Val 
    1880                 1885                 1890             


Phe Gln  Ile Trp Asp Asn Asp  Lys Phe Ser Phe Asp  Asp Phe Leu 
    1895                 1900                 1905             


Gly Ser  Leu Gln Leu Asp Leu  Asn Arg Met Pro Lys  Pro Ala Lys 
    1910                 1915                 1920             


Thr Ala  Lys Lys Cys Ser Leu  Asp Gln Leu Asp Asp  Ala Phe His 
    1925                 1930                 1935             


Pro Glu  Trp Phe Val Ser Leu  Phe Glu Gln Lys Thr  Val Lys Gly 
    1940                 1945                 1950             


Trp Trp  Pro Cys Val Ala Glu  Glu Gly Glu Lys Lys  Ile Leu Ala 
    1955                 1960                 1965             


Gly Lys  Leu Glu Met Thr Leu  Glu Ile Val Ala Glu  Ser Glu His 
    1970                 1975                 1980             


Glu Glu  Arg Pro Ala Gly Gln  Gly Arg Asp Glu Pro  Asn Met Asn 
    1985                 1990                 1995             


Pro Lys  Leu Glu Asp Pro Arg  Arg Pro Asp Thr Ser  Phe Leu Trp 
    2000                 2005                 2010             


Phe Thr  Ser Pro Tyr Lys Thr  Met Lys Phe Ile Leu  Trp Arg Arg 
    2015                 2020                 2025             


Phe Arg  Trp Ala Ile Ile Leu  Phe Ile Ile Leu Phe  Ile Leu Leu 
    2030                 2035                 2040             


Leu Phe  Leu Ala Ile Phe Ile  Tyr Ala Phe Pro Asn  Tyr Ala Ala 
    2045                 2050                 2055             


Met Lys  Leu Val Lys Pro Phe  Ser 
    2060                 2065     


<210>  1454
<211>  2087
<212>  PRT
<213>  Homo sapiens

<400>  1454

Met Leu Arg Val Phe Ile Leu Tyr Ala Glu Asn Val His Thr Pro Asp 
1               5                   10                  15      


Thr Asp Ile Ser Asp Ala Tyr Cys Ser Ala Val Phe Ala Gly Val Lys 
            20                  25                  30          


Lys Arg Thr Lys Val Ile Lys Asn Ser Val Asn Pro Val Trp Asn Glu 
        35                  40                  45              


Gly Phe Glu Trp Asp Leu Lys Gly Ile Pro Leu Asp Gln Gly Ser Glu 
    50                  55                  60                  


Leu His Val Val Val Lys Asp His Glu Thr Met Gly Arg Asn Arg Phe 
65                  70                  75                  80  


Leu Gly Glu Ala Lys Val Pro Leu Arg Glu Val Leu Ala Thr Pro Ser 
                85                  90                  95      


Leu Ser Ala Ser Phe Asn Ala Pro Leu Leu Asp Thr Lys Lys Gln Pro 
            100                 105                 110         


Thr Gly Ala Ser Leu Val Leu Gln Val Ser Tyr Thr Pro Leu Pro Gly 
        115                 120                 125             


Ala Val Pro Leu Phe Pro Pro Pro Thr Pro Leu Glu Pro Ser Pro Thr 
    130                 135                 140                 


Leu Pro Asp Leu Asp Val Val Ala Asp Thr Gly Gly Glu Glu Asp Thr 
145                 150                 155                 160 


Glu Asp Gln Gly Leu Thr Gly Asp Glu Ala Glu Pro Phe Leu Asp Gln 
                165                 170                 175     


Ser Gly Gly Pro Gly Ala Pro Thr Thr Pro Arg Lys Leu Pro Ser Arg 
            180                 185                 190         


Pro Pro Pro His Tyr Pro Gly Ile Lys Arg Lys Arg Ser Ala Pro Thr 
        195                 200                 205             


Ser Arg Lys Leu Leu Ser Asp Lys Pro Gln Asp Phe Gln Ile Arg Val 
    210                 215                 220                 


Gln Val Ile Glu Gly Arg Gln Leu Pro Gly Val Asn Ile Lys Pro Val 
225                 230                 235                 240 


Val Lys Val Thr Ala Ala Gly Gln Thr Lys Arg Thr Arg Ile His Lys 
                245                 250                 255     


Gly Asn Ser Pro Leu Phe Asn Glu Thr Leu Phe Phe Asn Leu Phe Asp 
            260                 265                 270         


Ser Pro Gly Glu Leu Phe Asp Glu Pro Ile Phe Ile Thr Val Val Asp 
        275                 280                 285             


Ser Arg Ser Leu Arg Thr Asp Ala Leu Leu Gly Glu Phe Arg Met Asp 
    290                 295                 300                 


Val Gly Thr Ile Tyr Arg Glu Pro Arg His Ala Tyr Leu Arg Lys Trp 
305                 310                 315                 320 


Leu Leu Leu Ser Asp Pro Asp Asp Phe Ser Ala Gly Ala Arg Gly Tyr 
                325                 330                 335     


Leu Lys Thr Ser Leu Cys Val Leu Gly Pro Gly Asp Glu Ala Pro Leu 
            340                 345                 350         


Glu Arg Lys Asp Pro Ser Glu Asp Lys Glu Asp Ile Glu Ser Asn Leu 
        355                 360                 365             


Leu Arg Pro Thr Gly Val Ala Leu Arg Gly Ala His Phe Cys Leu Lys 
    370                 375                 380                 


Val Phe Arg Ala Glu Asp Leu Pro Gln Met Asp Asp Ala Val Met Asp 
385                 390                 395                 400 


Asn Val Lys Gln Ile Phe Gly Phe Glu Ser Asn Lys Lys Asn Leu Val 
                405                 410                 415     


Asp Pro Phe Val Glu Val Ser Phe Ala Gly Lys Met Leu Cys Ser Lys 
            420                 425                 430         


Ile Leu Glu Lys Thr Ala Asn Pro Gln Trp Asn Gln Asn Ile Thr Leu 
        435                 440                 445             


Pro Ala Met Phe Pro Ser Met Cys Glu Lys Met Arg Ile Arg Ile Ile 
    450                 455                 460                 


Asp Trp Asp Arg Leu Thr His Asn Asp Ile Val Ala Thr Thr Tyr Leu 
465                 470                 475                 480 


Ser Met Ser Lys Ile Ser Ala Pro Gly Gly Glu Ile Glu Val Asp Asp 
                485                 490                 495     


Tyr Leu Gly Phe Leu Pro Thr Phe Gly Pro Cys Tyr Ile Asn Leu Tyr 
            500                 505                 510         


Gly Ser Pro Arg Glu Phe Thr Gly Phe Pro Asp Pro Tyr Thr Glu Leu 
        515                 520                 525             


Asn Thr Gly Lys Gly Glu Gly Val Ala Tyr Arg Gly Arg Leu Leu Leu 
    530                 535                 540                 


Ser Leu Glu Thr Lys Leu Val Glu His Ser Glu Gln Lys Val Glu Asp 
545                 550                 555                 560 


Leu Pro Ala Asp Asp Ile Leu Arg Val Glu Lys Tyr Leu Arg Arg Arg 
                565                 570                 575     


Lys Tyr Ser Leu Phe Ala Ala Phe Tyr Ser Ala Thr Met Leu Gln Asp 
            580                 585                 590         


Val Asp Asp Ala Ile Gln Phe Glu Val Ser Ile Gly Asn Tyr Gly Asn 
        595                 600                 605             


Lys Phe Asp Met Thr Cys Leu Pro Leu Ala Ser Thr Thr Gln Tyr Ser 
    610                 615                 620                 


Arg Ala Val Phe Asp Gly Cys His Tyr Tyr Tyr Leu Pro Trp Gly Asn 
625                 630                 635                 640 


Val Lys Pro Val Val Val Leu Ser Ser Tyr Trp Glu Asp Ile Ser His 
                645                 650                 655     


Arg Ile Glu Thr Gln Asn Gln Leu Leu Gly Ile Ala Asp Arg Leu Glu 
            660                 665                 670         


Ala Gly Leu Glu Gln Val His Leu Ala Leu Lys Ala Gln Cys Ser Thr 
        675                 680                 685             


Glu Asp Val Asp Ser Leu Val Ala Gln Leu Thr Asp Glu Leu Ile Ala 
    690                 695                 700                 


Gly Cys Ser Gln Pro Leu Gly Asp Ile His Glu Thr Pro Ser Ala Thr 
705                 710                 715                 720 


His Leu Asp Gln Tyr Leu Tyr Gln Leu Arg Thr His His Leu Ser Gln 
                725                 730                 735     


Ile Thr Glu Ala Ala Leu Ala Leu Lys Leu Gly His Ser Glu Leu Pro 
            740                 745                 750         


Ala Ala Leu Glu Gln Ala Glu Asp Trp Leu Leu Arg Leu Arg Ala Leu 
        755                 760                 765             


Ala Glu Glu Pro Gln Asn Ser Leu Pro Asp Ile Val Ile Trp Met Leu 
    770                 775                 780                 


Gln Gly Asp Lys Arg Val Ala Tyr Gln Arg Val Pro Ala His Gln Val 
785                 790                 795                 800 


Leu Phe Ser Arg Arg Gly Ala Asn Tyr Cys Gly Lys Asn Cys Gly Lys 
                805                 810                 815     


Leu Gln Thr Ile Phe Leu Lys Tyr Pro Met Glu Lys Val Pro Gly Ala 
            820                 825                 830         


Arg Met Pro Val Gln Ile Arg Val Lys Leu Trp Phe Gly Leu Ser Val 
        835                 840                 845             


Asp Glu Lys Glu Phe Asn Gln Phe Ala Glu Gly Lys Leu Ser Val Phe 
    850                 855                 860                 


Ala Glu Thr Tyr Glu Asn Glu Thr Lys Leu Ala Leu Val Gly Asn Trp 
865                 870                 875                 880 


Gly Thr Thr Gly Leu Thr Tyr Pro Lys Phe Ser Asp Val Thr Gly Lys 
                885                 890                 895     


Ile Lys Leu Pro Lys Asp Ser Phe Arg Pro Ser Ala Gly Trp Thr Trp 
            900                 905                 910         


Ala Gly Asp Trp Phe Val Cys Pro Glu Lys Thr Leu Leu His Asp Met 
        915                 920                 925             


Asp Ala Gly His Leu Ser Phe Val Glu Glu Val Phe Glu Asn Gln Thr 
    930                 935                 940                 


Arg Leu Pro Gly Gly Gln Trp Ile Tyr Met Ser Asp Asn Tyr Thr Asp 
945                 950                 955                 960 


Val Asn Gly Glu Lys Val Leu Pro Lys Asp Asp Ile Glu Cys Pro Leu 
                965                 970                 975     


Gly Trp Lys Trp Glu Asp Glu Glu Trp Ser Thr Asp Leu Asn Arg Ala 
            980                 985                 990         


Val Asp Glu Gln Gly Trp Glu Tyr  Ser Ile Thr Ile Pro  Pro Glu Arg 
        995                 1000                 1005             


Lys Pro  Lys His Trp Val Pro  Ala Glu Lys Met Tyr  Tyr Thr His 
    1010                 1015                 1020             


Arg Arg  Arg Arg Trp Val Arg  Leu Arg Arg Arg Asp  Leu Ser Gln 
    1025                 1030                 1035             


Met Glu  Ala Leu Lys Arg His  Arg Gln Ala Glu Ala  Glu Gly Glu 
    1040                 1045                 1050             


Gly Trp  Glu Tyr Ala Ser Leu  Phe Gly Trp Lys Phe  His Leu Glu 
    1055                 1060                 1065             


Tyr Arg  Lys Thr Asp Ala Phe  Arg Arg Arg Arg Trp  Arg Arg Arg 
    1070                 1075                 1080             


Met Glu  Pro Leu Glu Lys Thr  Gly Pro Ala Ala Val  Phe Ala Leu 
    1085                 1090                 1095             


Glu Gly  Ala Leu Gly Gly Val  Met Asp Asp Lys Ser  Glu Asp Ser 
    1100                 1105                 1110             


Met Ser  Val Ser Thr Leu Ser  Phe Gly Val Asn Arg  Pro Thr Ile 
    1115                 1120                 1125             


Ser Cys  Ile Phe Asp Tyr Gly  Asn Arg Tyr His Leu  Arg Cys Tyr 
    1130                 1135                 1140             


Met Tyr  Gln Ala Arg Asp Leu  Ala Ala Met Asp Lys  Asp Ser Phe 
    1145                 1150                 1155             


Ser Asp  Pro Tyr Ala Ile Val  Ser Phe Leu His Gln  Ser Gln Lys 
    1160                 1165                 1170             


Thr Val  Val Val Lys Asn Thr  Leu Asn Pro Thr Trp  Asp Gln Thr 
    1175                 1180                 1185             


Leu Ile  Phe Tyr Glu Ile Glu  Ile Phe Gly Glu Pro  Ala Thr Val 
    1190                 1195                 1200             


Ala Glu  Gln Pro Pro Ser Ile  Val Val Glu Leu Tyr  Asp His Asp 
    1205                 1210                 1215             


Thr Tyr  Gly Ala Asp Glu Phe  Met Gly Arg Cys Ile  Cys Gln Pro 
    1220                 1225                 1230             


Ser Leu  Glu Arg Met Pro Arg  Leu Ala Trp Phe Pro  Leu Thr Arg 
    1235                 1240                 1245             


Gly Ser  Gln Pro Ser Gly Glu  Leu Leu Ala Ser Phe  Glu Leu Ile 
    1250                 1255                 1260             


Gln Arg  Glu Lys Pro Ala Ile  His His Ile Pro Gly  Phe Glu Val 
    1265                 1270                 1275             


Gln Glu  Thr Ser Arg Ile Leu  Asp Glu Ser Glu Asp  Thr Asp Leu 
    1280                 1285                 1290             


Pro Tyr  Pro Pro Pro Gln Arg  Glu Ala Asn Ile Tyr  Met Val Pro 
    1295                 1300                 1305             


Gln Asn  Ile Lys Pro Ala Leu  Gln Arg Thr Ala Ile  Glu Ile Leu 
    1310                 1315                 1320             


Ala Trp  Gly Leu Arg Asn Met  Lys Ser Tyr Gln Leu  Ala Asn Ile 
    1325                 1330                 1335             


Ser Ser  Pro Ser Leu Val Val  Glu Cys Gly Gly Gln  Thr Val Gln 
    1340                 1345                 1350             


Ser Cys  Val Ile Arg Asn Leu  Arg Lys Asn Pro Asn  Phe Asp Ile 
    1355                 1360                 1365             


Cys Thr  Leu Phe Met Glu Val  Met Leu Pro Arg Glu  Glu Leu Tyr 
    1370                 1375                 1380             


Cys Pro  Pro Ile Thr Val Lys  Val Ile Asp Asn Arg  Gln Phe Gly 
    1385                 1390                 1395             


Arg Arg  Pro Val Val Gly Gln  Cys Thr Ile Arg Ser  Leu Glu Ser 
    1400                 1405                 1410             


Phe Leu  Cys Asp Pro Tyr Ser  Ala Glu Ser Pro Ser  Pro Gln Gly 
    1415                 1420                 1425             


Gly Pro  Asp Asp Val Ser Leu  Leu Ser Pro Gly Glu  Asp Val Leu 
    1430                 1435                 1440             


Ile Asp  Ile Asp Asp Lys Glu  Pro Leu Ile Pro Ile  Gln Leu Ala 
    1445                 1450                 1455             


Asp Gly  Leu Ser Ser Leu Ala  Pro Thr Asn Thr Ala  Ser Pro Pro 
    1460                 1465                 1470             


Ser Ser  Pro His Glu Glu Glu  Phe Ile Asp Trp Trp  Ser Lys Phe 
    1475                 1480                 1485             


Phe Ala  Ser Ile Gly Glu Arg  Glu Lys Cys Gly Ser  Tyr Leu Glu 
    1490                 1495                 1500             


Lys Asp  Phe Asp Thr Leu Lys  Val Tyr Asp Thr Gln  Leu Glu Asn 
    1505                 1510                 1515             


Val Glu  Ala Phe Glu Gly Leu  Ser Asp Phe Cys Asn  Thr Phe Lys 
    1520                 1525                 1530             


Leu Tyr  Arg Gly Lys Thr Gln  Glu Glu Thr Glu Asp  Pro Ser Val 
    1535                 1540                 1545             


Ile Gly  Glu Phe Lys Gly Leu  Phe Lys Ile Tyr Pro  Leu Pro Glu 
    1550                 1555                 1560             


Asp Pro  Ala Ile Pro Met Pro  Pro Arg Gln Phe His  Gln Leu Ala 
    1565                 1570                 1575             


Ala Gln  Gly Pro Gln Glu Cys  Leu Val Arg Ile Tyr  Ile Val Arg 
    1580                 1585                 1590             


Ala Phe  Gly Leu Gln Pro Lys  Asp Pro Asn Gly Lys  Cys Asp Pro 
    1595                 1600                 1605             


Tyr Ile  Lys Ile Ser Ile Gly  Lys Lys Ser Val Ser  Asp Gln Asp 
    1610                 1615                 1620             


Asn Tyr  Ile Pro Cys Thr Leu  Glu Pro Val Phe Gly  Lys Met Phe 
    1625                 1630                 1635             


Glu Leu  Thr Cys Thr Leu Pro  Leu Glu Lys Asp Leu  Lys Ile Thr 
    1640                 1645                 1650             


Leu Tyr  Asp Tyr Asp Leu Leu  Ser Lys Asp Glu Lys  Ile Gly Glu 
    1655                 1660                 1665             


Thr Val  Val Asp Leu Glu Asn  Arg Leu Leu Ser Lys  Phe Gly Ala 
    1670                 1675                 1680             


Arg Cys  Gly Leu Pro Gln Thr  Tyr Cys Val Ser Gly  Pro Asn Gln 
    1685                 1690                 1695             


Trp Arg  Asp Gln Leu Arg Pro  Ser Gln Leu Leu His  Leu Phe Cys 
    1700                 1705                 1710             


Gln Gln  His Arg Val Lys Ala  Pro Val Tyr Arg Thr  Asp Arg Val 
    1715                 1720                 1725             


Met Phe  Gln Asp Lys Glu Tyr  Ser Ile Glu Glu Ile  Glu Ala Gly 
    1730                 1735                 1740             


Arg Ile  Pro Asn Pro His Leu  Gly Pro Val Glu Glu  Arg Leu Ala 
    1745                 1750                 1755             


Leu His  Val Leu Gln Gln Gln  Gly Leu Val Pro Glu  His Val Glu 
    1760                 1765                 1770             


Ser Arg  Pro Leu Tyr Ser Pro  Leu Gln Pro Asp Ile  Glu Gln Gly 
    1775                 1780                 1785             


Lys Leu  Gln Met Trp Val Asp  Leu Phe Pro Lys Ala  Leu Gly Arg 
    1790                 1795                 1800             


Pro Gly  Pro Pro Phe Asn Ile  Thr Pro Arg Arg Ala  Arg Arg Phe 
    1805                 1810                 1815             


Phe Leu  Arg Cys Ile Ile Trp  Asn Thr Arg Asp Val  Ile Leu Asp 
    1820                 1825                 1830             


Asp Leu  Ser Leu Thr Gly Glu  Lys Met Ser Asp Ile  Tyr Val Lys 
    1835                 1840                 1845             


Gly Trp  Met Ile Gly Phe Glu  Glu His Lys Gln Lys  Thr Asp Val 
    1850                 1855                 1860             


His Tyr  Arg Ser Leu Gly Gly  Glu Gly Asn Phe Asn  Trp Arg Phe 
    1865                 1870                 1875             


Ile Phe  Pro Phe Asp Tyr Leu  Pro Ala Glu Gln Val  Cys Thr Ile 
    1880                 1885                 1890             


Ala Lys  Lys Asp Ala Phe Trp  Arg Leu Asp Lys Thr  Glu Ser Lys 
    1895                 1900                 1905             


Ile Pro  Ala Arg Val Val Phe  Gln Ile Trp Asp Asn  Asp Lys Phe 
    1910                 1915                 1920             


Ser Phe  Asp Asp Phe Leu Gly  Ser Leu Gln Leu Asp  Leu Asn Arg 
    1925                 1930                 1935             


Met Pro  Lys Pro Ala Lys Thr  Ala Lys Lys Cys Ser  Leu Asp Gln 
    1940                 1945                 1950             


Leu Asp  Asp Ala Phe His Pro  Glu Trp Phe Val Ser  Leu Phe Glu 
    1955                 1960                 1965             


Gln Lys  Thr Val Lys Gly Trp  Trp Pro Cys Val Ala  Glu Glu Gly 
    1970                 1975                 1980             


Glu Lys  Lys Ile Leu Ala Gly  Lys Leu Glu Met Thr  Leu Glu Ile 
    1985                 1990                 1995             


Val Ala  Glu Ser Glu His Glu  Glu Arg Pro Ala Gly  Gln Gly Arg 
    2000                 2005                 2010             


Asp Glu  Pro Asn Met Asn Pro  Lys Leu Glu Asp Pro  Arg Arg Pro 
    2015                 2020                 2025             


Asp Thr  Ser Phe Leu Trp Phe  Thr Ser Pro Tyr Lys  Thr Met Lys 
    2030                 2035                 2040             


Phe Ile  Leu Trp Arg Arg Phe  Arg Trp Ala Ile Ile  Leu Phe Ile 
    2045                 2050                 2055             


Ile Leu  Phe Ile Leu Leu Leu  Phe Leu Ala Ile Phe  Ile Tyr Ala 
    2060                 2065                 2070             


Phe Pro  Asn Tyr Ala Ala Met  Lys Leu Val Lys Pro  Phe Ser 
    2075                 2080                 2085         


<210>  1455
<211>  2101
<212>  PRT
<213>  Homo sapiens

<400>  1455

Met Leu Arg Val Phe Ile Leu Tyr Ala Glu Asn Val His Thr Pro Asp 
1               5                   10                  15      


Thr Asp Ile Ser Asp Ala Tyr Cys Ser Ala Val Phe Ala Gly Val Lys 
            20                  25                  30          


Lys Arg Thr Lys Val Ile Lys Asn Ser Val Asn Pro Val Trp Asn Glu 
        35                  40                  45              


Gly Phe Glu Trp Asp Leu Lys Gly Ile Pro Leu Asp Gln Gly Ser Glu 
    50                  55                  60                  


Leu His Val Val Val Lys Asp His Glu Thr Met Gly Arg Asn Arg Phe 
65                  70                  75                  80  


Leu Gly Glu Ala Lys Val Pro Leu Arg Glu Val Leu Ala Thr Pro Ser 
                85                  90                  95      


Leu Ser Ala Ser Phe Asn Ala Pro Leu Leu Asp Thr Lys Lys Gln Pro 
            100                 105                 110         


Thr Gly Ala Ser Leu Val Leu Gln Val Ser Tyr Thr Pro Leu Pro Gly 
        115                 120                 125             


Ala Val Pro Leu Phe Pro Pro Pro Thr Pro Leu Glu Pro Ser Pro Thr 
    130                 135                 140                 


Leu Pro Asp Leu Asp Val Val Ala Asp Thr Gly Gly Glu Glu Asp Thr 
145                 150                 155                 160 


Glu Asp Gln Gly Leu Thr Gly Asp Glu Ala Glu Pro Phe Leu Asp Gln 
                165                 170                 175     


Ser Gly Gly Pro Gly Ala Pro Thr Thr Pro Arg Lys Leu Pro Ser Arg 
            180                 185                 190         


Pro Pro Pro His Tyr Pro Gly Ile Lys Arg Lys Arg Ser Ala Pro Thr 
        195                 200                 205             


Ser Arg Lys Leu Leu Ser Asp Lys Pro Gln Asp Phe Gln Ile Arg Val 
    210                 215                 220                 


Gln Val Ile Glu Gly Arg Gln Leu Pro Gly Val Asn Ile Lys Pro Val 
225                 230                 235                 240 


Val Lys Val Thr Ala Ala Gly Gln Thr Lys Arg Thr Arg Ile His Lys 
                245                 250                 255     


Gly Asn Ser Pro Leu Phe Asn Glu Thr Leu Phe Phe Asn Leu Phe Asp 
            260                 265                 270         


Ser Pro Gly Glu Leu Phe Asp Glu Pro Ile Phe Ile Thr Val Val Asp 
        275                 280                 285             


Ser Arg Ser Leu Arg Thr Asp Ala Leu Leu Gly Glu Phe Arg Met Asp 
    290                 295                 300                 


Val Gly Thr Ile Tyr Arg Glu Pro Arg His Ala Tyr Leu Arg Lys Trp 
305                 310                 315                 320 


Leu Leu Leu Ser Asp Pro Asp Asp Phe Ser Ala Gly Ala Arg Gly Tyr 
                325                 330                 335     


Leu Lys Thr Ser Leu Cys Val Leu Gly Pro Gly Asp Glu Ala Pro Leu 
            340                 345                 350         


Glu Arg Lys Asp Pro Ser Glu Asp Lys Glu Asp Ile Glu Ser Asn Leu 
        355                 360                 365             


Leu Arg Pro Thr Gly Val Ala Leu Arg Gly Ala His Phe Cys Leu Lys 
    370                 375                 380                 


Val Phe Arg Ala Glu Asp Leu Pro Gln Met Asp Asp Ala Val Met Asp 
385                 390                 395                 400 


Asn Val Lys Gln Ile Phe Gly Phe Glu Ser Asn Lys Lys Asn Leu Val 
                405                 410                 415     


Asp Pro Phe Val Glu Val Ser Phe Ala Gly Lys Met Leu Cys Ser Lys 
            420                 425                 430         


Ile Leu Glu Lys Thr Ala Asn Pro Gln Trp Asn Gln Asn Ile Thr Leu 
        435                 440                 445             


Pro Ala Met Phe Pro Ser Met Cys Glu Lys Met Arg Ile Arg Ile Ile 
    450                 455                 460                 


Asp Trp Asp Arg Leu Thr His Asn Asp Ile Val Ala Thr Thr Tyr Leu 
465                 470                 475                 480 


Ser Met Ser Lys Ile Ser Ala Pro Gly Gly Glu Ile Glu Glu Glu Pro 
                485                 490                 495     


Ala Gly Ala Val Lys Pro Ser Lys Ala Ser Asp Leu Asp Asp Tyr Leu 
            500                 505                 510         


Gly Phe Leu Pro Thr Phe Gly Pro Cys Tyr Ile Asn Leu Tyr Gly Ser 
        515                 520                 525             


Pro Arg Glu Phe Thr Gly Phe Pro Asp Pro Tyr Thr Glu Leu Asn Thr 
    530                 535                 540                 


Gly Lys Gly Glu Gly Val Ala Tyr Arg Gly Arg Leu Leu Leu Ser Leu 
545                 550                 555                 560 


Glu Thr Lys Leu Val Glu His Ser Glu Gln Lys Val Glu Asp Leu Pro 
                565                 570                 575     


Ala Asp Asp Ile Leu Arg Val Glu Lys Tyr Leu Arg Arg Arg Lys Tyr 
            580                 585                 590         


Ser Leu Phe Ala Ala Phe Tyr Ser Ala Thr Met Leu Gln Asp Val Asp 
        595                 600                 605             


Asp Ala Ile Gln Phe Glu Val Ser Ile Gly Asn Tyr Gly Asn Lys Phe 
    610                 615                 620                 


Asp Met Thr Cys Leu Pro Leu Ala Ser Thr Thr Gln Tyr Ser Arg Ala 
625                 630                 635                 640 


Val Phe Asp Gly Cys His Tyr Tyr Tyr Leu Pro Trp Gly Asn Val Lys 
                645                 650                 655     


Pro Val Val Val Leu Ser Ser Tyr Trp Glu Asp Ile Ser His Arg Ile 
            660                 665                 670         


Glu Thr Gln Asn Gln Leu Leu Gly Ile Ala Asp Arg Leu Glu Ala Gly 
        675                 680                 685             


Leu Glu Gln Val His Leu Ala Leu Lys Ala Gln Cys Ser Thr Glu Asp 
    690                 695                 700                 


Val Asp Ser Leu Val Ala Gln Leu Thr Asp Glu Leu Ile Ala Gly Cys 
705                 710                 715                 720 


Ser Gln Pro Leu Gly Asp Ile His Glu Thr Pro Ser Ala Thr His Leu 
                725                 730                 735     


Asp Gln Tyr Leu Tyr Gln Leu Arg Thr His His Leu Ser Gln Ile Thr 
            740                 745                 750         


Glu Ala Ala Leu Ala Leu Lys Leu Gly His Ser Glu Leu Pro Ala Ala 
        755                 760                 765             


Leu Glu Gln Ala Glu Asp Trp Leu Leu Arg Leu Arg Ala Leu Ala Glu 
    770                 775                 780                 


Glu Pro Gln Asn Ser Leu Pro Asp Ile Val Ile Trp Met Leu Gln Gly 
785                 790                 795                 800 


Asp Lys Arg Val Ala Tyr Gln Arg Val Pro Ala His Gln Val Leu Phe 
                805                 810                 815     


Ser Arg Arg Gly Ala Asn Tyr Cys Gly Lys Asn Cys Gly Lys Leu Gln 
            820                 825                 830         


Thr Ile Phe Leu Lys Tyr Pro Met Glu Lys Val Pro Gly Ala Arg Met 
        835                 840                 845             


Pro Val Gln Ile Arg Val Lys Leu Trp Phe Gly Leu Ser Val Asp Glu 
    850                 855                 860                 


Lys Glu Phe Asn Gln Phe Ala Glu Gly Lys Leu Ser Val Phe Ala Glu 
865                 870                 875                 880 


Thr Tyr Glu Asn Glu Thr Lys Leu Ala Leu Val Gly Asn Trp Gly Thr 
                885                 890                 895     


Thr Gly Leu Thr Tyr Pro Lys Phe Ser Asp Val Thr Gly Lys Ile Lys 
            900                 905                 910         


Leu Pro Lys Asp Ser Phe Arg Pro Ser Ala Gly Trp Thr Trp Ala Gly 
        915                 920                 925             


Asp Trp Phe Val Cys Pro Glu Lys Thr Leu Leu His Asp Met Asp Ala 
    930                 935                 940                 


Gly His Leu Ser Phe Val Glu Glu Val Phe Glu Asn Gln Thr Arg Leu 
945                 950                 955                 960 


Pro Gly Gly Gln Trp Ile Tyr Met Ser Asp Asn Tyr Thr Asp Val Asn 
                965                 970                 975     


Gly Glu Lys Val Leu Pro Lys Asp Asp Ile Glu Cys Pro Leu Gly Trp 
            980                 985                 990         


Lys Trp Glu Asp Glu Glu Trp Ser  Thr Asp Leu Asn Arg  Ala Val Asp 
        995                 1000                 1005             


Glu Gln  Gly Trp Glu Tyr Ser  Ile Thr Ile Pro Pro  Glu Arg Lys 
    1010                 1015                 1020             


Pro Lys  His Trp Val Pro Ala  Glu Lys Met Tyr Tyr  Thr His Arg 
    1025                 1030                 1035             


Arg Arg  Arg Trp Val Arg Leu  Arg Arg Arg Asp Leu  Ser Gln Met 
    1040                 1045                 1050             


Glu Ala  Leu Lys Arg His Arg  Gln Ala Glu Ala Glu  Gly Glu Gly 
    1055                 1060                 1065             


Trp Glu  Tyr Ala Ser Leu Phe  Gly Trp Lys Phe His  Leu Glu Tyr 
    1070                 1075                 1080             


Arg Lys  Thr Asp Ala Phe Arg  Arg Arg Arg Trp Arg  Arg Arg Met 
    1085                 1090                 1095             


Glu Pro  Leu Glu Lys Thr Gly  Pro Ala Ala Val Phe  Ala Leu Glu 
    1100                 1105                 1110             


Gly Ala  Leu Gly Gly Val Met  Asp Asp Lys Ser Glu  Asp Ser Met 
    1115                 1120                 1125             


Ser Val  Ser Thr Leu Ser Phe  Gly Val Asn Arg Pro  Thr Ile Ser 
    1130                 1135                 1140             


Cys Ile  Phe Asp Tyr Gly Asn  Arg Tyr His Leu Arg  Cys Tyr Met 
    1145                 1150                 1155             


Tyr Gln  Ala Arg Asp Leu Ala  Ala Met Asp Lys Asp  Ser Phe Ser 
    1160                 1165                 1170             


Asp Pro  Tyr Ala Ile Val Ser  Phe Leu His Gln Ser  Gln Lys Thr 
    1175                 1180                 1185             


Val Val  Val Lys Asn Thr Leu  Asn Pro Thr Trp Asp  Gln Thr Leu 
    1190                 1195                 1200             


Ile Phe  Tyr Glu Ile Glu Ile  Phe Gly Glu Pro Ala  Thr Val Ala 
    1205                 1210                 1215             


Glu Gln  Pro Pro Ser Ile Val  Val Glu Leu Tyr Asp  His Asp Thr 
    1220                 1225                 1230             


Tyr Gly  Ala Asp Glu Phe Met  Gly Arg Cys Ile Cys  Gln Pro Ser 
    1235                 1240                 1245             


Leu Glu  Arg Met Pro Arg Leu  Ala Trp Phe Pro Leu  Thr Arg Gly 
    1250                 1255                 1260             


Ser Gln  Pro Ser Gly Glu Leu  Leu Ala Ser Phe Glu  Leu Ile Gln 
    1265                 1270                 1275             


Arg Glu  Lys Pro Ala Ile His  His Ile Pro Gly Phe  Glu Val Gln 
    1280                 1285                 1290             


Glu Thr  Ser Arg Ile Leu Asp  Glu Ser Glu Asp Thr  Asp Leu Pro 
    1295                 1300                 1305             


Tyr Pro  Pro Pro Gln Arg Glu  Ala Asn Ile Tyr Met  Val Pro Gln 
    1310                 1315                 1320             


Asn Ile  Lys Pro Ala Leu Gln  Arg Thr Ala Ile Glu  Ile Leu Ala 
    1325                 1330                 1335             


Trp Gly  Leu Arg Asn Met Lys  Ser Tyr Gln Leu Ala  Asn Ile Ser 
    1340                 1345                 1350             


Ser Pro  Ser Leu Val Val Glu  Cys Gly Gly Gln Thr  Val Gln Ser 
    1355                 1360                 1365             


Cys Val  Ile Arg Asn Leu Arg  Lys Asn Pro Asn Phe  Asp Ile Cys 
    1370                 1375                 1380             


Thr Leu  Phe Met Glu Val Met  Leu Pro Arg Glu Glu  Leu Tyr Cys 
    1385                 1390                 1395             


Pro Pro  Ile Thr Val Lys Val  Ile Asp Asn Arg Gln  Phe Gly Arg 
    1400                 1405                 1410             


Arg Pro  Val Val Gly Gln Cys  Thr Ile Arg Ser Leu  Glu Ser Phe 
    1415                 1420                 1425             


Leu Cys  Asp Pro Tyr Ser Ala  Glu Ser Pro Ser Pro  Gln Gly Gly 
    1430                 1435                 1440             


Pro Asp  Asp Val Ser Leu Leu  Ser Pro Gly Glu Asp  Val Leu Ile 
    1445                 1450                 1455             


Asp Ile  Asp Asp Lys Glu Pro  Leu Ile Pro Ile Gln  Leu Ala Asp 
    1460                 1465                 1470             


Gly Leu  Ser Ser Leu Ala Pro  Thr Asn Thr Ala Ser  Pro Pro Ser 
    1475                 1480                 1485             


Ser Pro  His Glu Glu Glu Phe  Ile Asp Trp Trp Ser  Lys Phe Phe 
    1490                 1495                 1500             


Ala Ser  Ile Gly Glu Arg Glu  Lys Cys Gly Ser Tyr  Leu Glu Lys 
    1505                 1510                 1515             


Asp Phe  Asp Thr Leu Lys Val  Tyr Asp Thr Gln Leu  Glu Asn Val 
    1520                 1525                 1530             


Glu Ala  Phe Glu Gly Leu Ser  Asp Phe Cys Asn Thr  Phe Lys Leu 
    1535                 1540                 1545             


Tyr Arg  Gly Lys Thr Gln Glu  Glu Thr Glu Asp Pro  Ser Val Ile 
    1550                 1555                 1560             


Gly Glu  Phe Lys Gly Leu Phe  Lys Ile Tyr Pro Leu  Pro Glu Asp 
    1565                 1570                 1575             


Pro Ala  Ile Pro Met Pro Pro  Arg Gln Phe His Gln  Leu Ala Ala 
    1580                 1585                 1590             


Gln Gly  Pro Gln Glu Cys Leu  Val Arg Ile Tyr Ile  Val Arg Ala 
    1595                 1600                 1605             


Phe Gly  Leu Gln Pro Lys Asp  Pro Asn Gly Lys Cys  Asp Pro Tyr 
    1610                 1615                 1620             


Ile Lys  Ile Ser Ile Gly Lys  Lys Ser Val Ser Asp  Gln Asp Asn 
    1625                 1630                 1635             


Tyr Ile  Pro Cys Thr Leu Glu  Pro Val Phe Gly Lys  Met Phe Glu 
    1640                 1645                 1650             


Leu Thr  Cys Thr Leu Pro Leu  Glu Lys Asp Leu Lys  Ile Thr Leu 
    1655                 1660                 1665             


Tyr Asp  Tyr Asp Leu Leu Ser  Lys Asp Glu Lys Ile  Gly Glu Thr 
    1670                 1675                 1680             


Val Val  Asp Leu Glu Asn Arg  Leu Leu Ser Lys Phe  Gly Ala Arg 
    1685                 1690                 1695             


Cys Gly  Leu Pro Gln Thr Tyr  Cys Val Ser Gly Pro  Asn Gln Trp 
    1700                 1705                 1710             


Arg Asp  Gln Leu Arg Pro Ser  Gln Leu Leu His Leu  Phe Cys Gln 
    1715                 1720                 1725             


Gln His  Arg Val Lys Ala Pro  Val Tyr Arg Thr Asp  Arg Val Met 
    1730                 1735                 1740             


Phe Gln  Asp Lys Glu Tyr Ser  Ile Glu Glu Ile Glu  Ala Gly Arg 
    1745                 1750                 1755             


Ile Pro  Asn Pro His Leu Gly  Pro Val Glu Glu Arg  Leu Ala Leu 
    1760                 1765                 1770             


His Val  Leu Gln Gln Gln Gly  Leu Val Pro Glu His  Val Glu Ser 
    1775                 1780                 1785             


Arg Pro  Leu Tyr Ser Pro Leu  Gln Pro Asp Ile Glu  Gln Gly Lys 
    1790                 1795                 1800             


Leu Gln  Met Trp Val Asp Leu  Phe Pro Lys Ala Leu  Gly Arg Pro 
    1805                 1810                 1815             


Gly Pro  Pro Phe Asn Ile Thr  Pro Arg Arg Ala Arg  Arg Phe Phe 
    1820                 1825                 1830             


Leu Arg  Cys Ile Ile Trp Asn  Thr Arg Asp Val Ile  Leu Asp Asp 
    1835                 1840                 1845             


Leu Ser  Leu Thr Gly Glu Lys  Met Ser Asp Ile Tyr  Val Lys Gly 
    1850                 1855                 1860             


Trp Met  Ile Gly Phe Glu Glu  His Lys Gln Lys Thr  Asp Val His 
    1865                 1870                 1875             


Tyr Arg  Ser Leu Gly Gly Glu  Gly Asn Phe Asn Trp  Arg Phe Ile 
    1880                 1885                 1890             


Phe Pro  Phe Asp Tyr Leu Pro  Ala Glu Gln Val Cys  Thr Ile Ala 
    1895                 1900                 1905             


Lys Lys  Asp Ala Phe Trp Arg  Leu Asp Lys Thr Glu  Ser Lys Ile 
    1910                 1915                 1920             


Pro Ala  Arg Val Val Phe Gln  Ile Trp Asp Asn Asp  Lys Phe Ser 
    1925                 1930                 1935             


Phe Asp  Asp Phe Leu Gly Ser  Leu Gln Leu Asp Leu  Asn Arg Met 
    1940                 1945                 1950             


Pro Lys  Pro Ala Lys Thr Ala  Lys Lys Cys Ser Leu  Asp Gln Leu 
    1955                 1960                 1965             


Asp Asp  Ala Phe His Pro Glu  Trp Phe Val Ser Leu  Phe Glu Gln 
    1970                 1975                 1980             


Lys Thr  Val Lys Gly Trp Trp  Pro Cys Val Ala Glu  Glu Gly Glu 
    1985                 1990                 1995             


Lys Lys  Ile Leu Ala Gly Lys  Leu Glu Met Thr Leu  Glu Ile Val 
    2000                 2005                 2010             


Ala Glu  Ser Glu His Glu Glu  Arg Pro Ala Gly Gln  Gly Arg Asp 
    2015                 2020                 2025             


Glu Pro  Asn Met Asn Pro Lys  Leu Glu Asp Pro Arg  Arg Pro Asp 
    2030                 2035                 2040             


Thr Ser  Phe Leu Trp Phe Thr  Ser Pro Tyr Lys Thr  Met Lys Phe 
    2045                 2050                 2055             


Ile Leu  Trp Arg Arg Phe Arg  Trp Ala Ile Ile Leu  Phe Ile Ile 
    2060                 2065                 2070             


Leu Phe  Ile Leu Leu Leu Phe  Leu Ala Ile Phe Ile  Tyr Ala Phe 
    2075                 2080                 2085             


Pro Asn  Tyr Ala Ala Met Lys  Leu Val Lys Pro Phe  Ser 
    2090                 2095                 2100     


<210>  1456
<211>  2111
<212>  PRT
<213>  Homo sapiens

<400>  1456

Met Leu Arg Val Phe Ile Leu Tyr Ala Glu Asn Val His Thr Pro Asp 
1               5                   10                  15      


Thr Asp Ile Ser Asp Ala Tyr Cys Ser Ala Val Phe Ala Gly Val Lys 
            20                  25                  30          


Lys Arg Thr Lys Val Ile Lys Asn Ser Val Asn Pro Val Trp Asn Glu 
        35                  40                  45              


Gly Phe Glu Trp Asp Leu Lys Gly Ile Pro Leu Asp Gln Gly Ser Glu 
    50                  55                  60                  


Leu His Val Val Val Lys Asp His Glu Thr Met Gly Arg Asn Arg Phe 
65                  70                  75                  80  


Leu Gly Glu Ala Lys Val Pro Leu Arg Glu Val Leu Ala Thr Pro Ser 
                85                  90                  95      


Leu Ser Ala Ser Phe Asn Ala Pro Leu Leu Asp Thr Lys Lys Gln Pro 
            100                 105                 110         


Thr Gly Ala Ser Leu Val Leu Gln Val Ser Tyr Thr Pro Leu Pro Gly 
        115                 120                 125             


Ala Val Pro Leu Phe Pro Pro Pro Thr Pro Leu Glu Pro Ser Pro Thr 
    130                 135                 140                 


Leu Pro Asp Leu Asp Val Val Ala Gly Gly Gly Gln Ser Arg Ala Glu 
145                 150                 155                 160 


Thr Trp Ser Leu Leu Ser Asp Ser Thr Met Asp Thr Arg Tyr Ser Gly 
                165                 170                 175     


Lys Lys Trp Pro Ala Pro Thr Asp Thr Gly Gly Glu Glu Asp Thr Glu 
            180                 185                 190         


Asp Gln Gly Leu Thr Gly Asp Glu Ala Glu Pro Phe Leu Asp Gln Ser 
        195                 200                 205             


Gly Gly Pro Gly Ala Pro Thr Thr Pro Arg Lys Leu Pro Ser Arg Pro 
    210                 215                 220                 


Pro Pro His Tyr Pro Gly Ile Lys Arg Lys Arg Ser Ala Pro Thr Ser 
225                 230                 235                 240 


Arg Lys Leu Leu Ser Asp Lys Pro Gln Asp Phe Gln Ile Arg Val Gln 
                245                 250                 255     


Val Ile Glu Gly Arg Gln Leu Pro Gly Val Asn Ile Lys Pro Val Val 
            260                 265                 270         


Lys Val Thr Ala Ala Gly Gln Thr Lys Arg Thr Arg Ile His Lys Gly 
        275                 280                 285             


Asn Ser Pro Leu Phe Asn Glu Thr Leu Phe Phe Asn Leu Phe Asp Ser 
    290                 295                 300                 


Pro Gly Glu Leu Phe Asp Glu Pro Ile Phe Ile Thr Val Val Asp Ser 
305                 310                 315                 320 


Arg Ser Leu Arg Thr Asp Ala Leu Leu Gly Glu Phe Arg Met Asp Val 
                325                 330                 335     


Gly Thr Ile Tyr Arg Glu Pro Arg His Ala Tyr Leu Arg Lys Trp Leu 
            340                 345                 350         


Leu Leu Ser Asp Pro Asp Asp Phe Ser Ala Gly Ala Arg Gly Tyr Leu 
        355                 360                 365             


Lys Thr Ser Leu Cys Val Leu Gly Pro Gly Asp Glu Ala Pro Leu Glu 
    370                 375                 380                 


Arg Lys Asp Pro Ser Glu Asp Lys Glu Asp Ile Glu Ser Asn Leu Leu 
385                 390                 395                 400 


Arg Pro Thr Gly Val Ala Leu Arg Gly Ala His Phe Cys Leu Lys Val 
                405                 410                 415     


Phe Arg Ala Glu Asp Leu Pro Gln Met Asp Asp Ala Val Met Asp Asn 
            420                 425                 430         


Val Lys Gln Ile Phe Gly Phe Glu Ser Asn Lys Lys Asn Leu Val Asp 
        435                 440                 445             


Pro Phe Val Glu Val Ser Phe Ala Gly Lys Met Leu Cys Ser Lys Ile 
    450                 455                 460                 


Leu Glu Lys Thr Ala Asn Pro Gln Trp Asn Gln Asn Ile Thr Leu Pro 
465                 470                 475                 480 


Ala Met Phe Pro Ser Met Cys Glu Lys Met Arg Ile Arg Ile Ile Asp 
                485                 490                 495     


Trp Asp Arg Leu Thr His Asn Asp Ile Val Ala Thr Thr Tyr Leu Ser 
            500                 505                 510         


Met Ser Lys Ile Ser Ala Pro Gly Gly Glu Ile Glu Glu Glu Pro Ala 
        515                 520                 525             


Gly Ala Val Lys Pro Ser Lys Ala Ser Asp Leu Asp Asp Tyr Leu Gly 
    530                 535                 540                 


Phe Leu Pro Thr Phe Gly Pro Cys Tyr Ile Asn Leu Tyr Gly Ser Pro 
545                 550                 555                 560 


Arg Glu Phe Thr Gly Phe Pro Asp Pro Tyr Thr Glu Leu Asn Thr Gly 
                565                 570                 575     


Lys Gly Glu Gly Val Ala Tyr Arg Gly Arg Leu Leu Leu Ser Leu Glu 
            580                 585                 590         


Thr Lys Leu Val Glu His Ser Glu Gln Lys Val Glu Asp Leu Pro Ala 
        595                 600                 605             


Asp Asp Ile Leu Arg Val Glu Lys Tyr Leu Arg Arg Arg Lys Tyr Ser 
    610                 615                 620                 


Leu Phe Ala Ala Phe Tyr Ser Ala Thr Met Leu Gln Asp Val Asp Asp 
625                 630                 635                 640 


Ala Ile Gln Phe Glu Val Ser Ile Gly Asn Tyr Gly Asn Lys Phe Asp 
                645                 650                 655     


Met Thr Cys Leu Pro Leu Ala Ser Thr Thr Gln Tyr Ser Arg Ala Val 
            660                 665                 670         


Phe Asp Gly Cys His Tyr Tyr Tyr Leu Pro Trp Gly Asn Val Lys Pro 
        675                 680                 685             


Val Val Val Leu Ser Ser Tyr Trp Glu Asp Ile Ser His Arg Ile Glu 
    690                 695                 700                 


Thr Gln Asn Gln Leu Leu Gly Ile Ala Asp Arg Leu Glu Ala Gly Leu 
705                 710                 715                 720 


Glu Gln Val His Leu Ala Leu Lys Ala Gln Cys Ser Thr Glu Asp Val 
                725                 730                 735     


Asp Ser Leu Val Ala Gln Leu Thr Asp Glu Leu Ile Ala Gly Cys Ser 
            740                 745                 750         


Gln Pro Leu Gly Asp Ile His Glu Thr Pro Ser Ala Thr His Leu Asp 
        755                 760                 765             


Gln Tyr Leu Tyr Gln Leu Arg Thr His His Leu Ser Gln Ile Thr Glu 
    770                 775                 780                 


Ala Ala Leu Ala Leu Lys Leu Gly His Ser Glu Leu Pro Ala Ala Leu 
785                 790                 795                 800 


Glu Gln Ala Glu Asp Trp Leu Leu Arg Leu Arg Ala Leu Ala Glu Glu 
                805                 810                 815     


Pro Gln Asn Ser Leu Pro Asp Ile Val Ile Trp Met Leu Gln Gly Asp 
            820                 825                 830         


Lys Arg Val Ala Tyr Gln Arg Val Pro Ala His Gln Val Leu Phe Ser 
        835                 840                 845             


Arg Arg Gly Ala Asn Tyr Cys Gly Lys Asn Cys Gly Lys Leu Gln Thr 
    850                 855                 860                 


Ile Phe Leu Lys Tyr Pro Met Glu Lys Val Pro Gly Ala Arg Met Pro 
865                 870                 875                 880 


Val Gln Ile Arg Val Lys Leu Trp Phe Gly Leu Ser Val Asp Glu Lys 
                885                 890                 895     


Glu Phe Asn Gln Phe Ala Glu Gly Lys Leu Ser Val Phe Ala Glu Thr 
            900                 905                 910         


Tyr Glu Asn Glu Thr Lys Leu Ala Leu Val Gly Asn Trp Gly Thr Thr 
        915                 920                 925             


Gly Leu Thr Tyr Pro Lys Phe Ser Asp Val Thr Gly Lys Ile Lys Leu 
    930                 935                 940                 


Pro Lys Asp Ser Phe Arg Pro Ser Ala Gly Trp Thr Trp Ala Gly Asp 
945                 950                 955                 960 


Trp Phe Val Cys Pro Glu Lys Thr Leu Leu His Asp Met Asp Ala Gly 
                965                 970                 975     


His Leu Ser Phe Val Glu Glu Val Phe Glu Asn Gln Thr Arg Leu Pro 
            980                 985                 990         


Gly Gly Gln Trp Ile Tyr Met Ser  Asp Asn Tyr Thr Asp  Val Asn Gly 
        995                 1000                 1005             


Glu Lys  Val Leu Pro Lys Asp  Asp Ile Glu Cys Pro  Leu Gly Trp 
    1010                 1015                 1020             


Lys Trp  Glu Asp Glu Glu Trp  Ser Thr Asp Leu Asn  Arg Ala Val 
    1025                 1030                 1035             


Asp Glu  Gln Gly Trp Glu Tyr  Ser Ile Thr Ile Pro  Pro Glu Arg 
    1040                 1045                 1050             


Lys Pro  Lys His Trp Val Pro  Ala Glu Lys Met Tyr  Tyr Thr His 
    1055                 1060                 1065             


Arg Arg  Arg Arg Trp Val Arg  Leu Arg Arg Arg Asp  Leu Ser Gln 
    1070                 1075                 1080             


Met Glu  Ala Leu Lys Arg His  Arg Gln Ala Glu Ala  Glu Gly Glu 
    1085                 1090                 1095             


Gly Trp  Glu Tyr Ala Ser Leu  Phe Gly Trp Lys Phe  His Leu Glu 
    1100                 1105                 1110             


Tyr Arg  Lys Thr Asp Ala Phe  Arg Arg Arg Arg Trp  Arg Arg Arg 
    1115                 1120                 1125             


Met Glu  Pro Leu Glu Lys Thr  Gly Pro Ala Ala Val  Phe Ala Leu 
    1130                 1135                 1140             


Glu Gly  Ala Leu Gly Gly Val  Met Asp Asp Lys Ser  Glu Asp Ser 
    1145                 1150                 1155             


Met Ser  Val Ser Thr Leu Ser  Phe Gly Val Asn Arg  Pro Thr Ile 
    1160                 1165                 1170             


Ser Cys  Ile Phe Asp Tyr Gly  Asn Arg Tyr His Leu  Arg Cys Tyr 
    1175                 1180                 1185             


Met Tyr  Gln Ala Arg Asp Leu  Ala Ala Met Asp Lys  Asp Ser Phe 
    1190                 1195                 1200             


Ser Asp  Pro Tyr Ala Ile Val  Ser Phe Leu His Gln  Ser Gln Lys 
    1205                 1210                 1215             


Thr Val  Val Val Lys Asn Thr  Leu Asn Pro Thr Trp  Asp Gln Thr 
    1220                 1225                 1230             


Leu Ile  Phe Tyr Glu Ile Glu  Ile Phe Gly Glu Pro  Ala Thr Val 
    1235                 1240                 1245             


Ala Glu  Gln Pro Pro Ser Ile  Val Val Glu Leu Tyr  Asp His Asp 
    1250                 1255                 1260             


Thr Tyr  Gly Ala Asp Glu Phe  Met Gly Arg Cys Ile  Cys Gln Pro 
    1265                 1270                 1275             


Ser Leu  Glu Arg Met Pro Arg  Leu Ala Trp Phe Pro  Leu Thr Arg 
    1280                 1285                 1290             


Gly Ser  Gln Pro Ser Gly Glu  Leu Leu Ala Ser Phe  Glu Leu Ile 
    1295                 1300                 1305             


Gln Arg  Glu Lys Pro Ala Ile  His His Ile Pro Gly  Phe Glu Val 
    1310                 1315                 1320             


Gln Glu  Thr Ser Arg Ile Leu  Asp Glu Ser Glu Asp  Thr Asp Leu 
    1325                 1330                 1335             


Pro Tyr  Pro Pro Pro Gln Arg  Glu Ala Asn Ile Tyr  Met Val Pro 
    1340                 1345                 1350             


Gln Asn  Ile Lys Pro Ala Leu  Gln Arg Thr Ala Ile  Glu Ile Leu 
    1355                 1360                 1365             


Ala Trp  Gly Leu Arg Asn Met  Lys Ser Tyr Gln Leu  Ala Asn Ile 
    1370                 1375                 1380             


Ser Ser  Pro Ser Leu Val Val  Glu Cys Gly Gly Gln  Thr Val Gln 
    1385                 1390                 1395             


Ser Cys  Val Ile Arg Asn Leu  Arg Lys Asn Pro Asn  Phe Asp Ile 
    1400                 1405                 1410             


Cys Thr  Leu Phe Met Glu Val  Met Leu Pro Arg Glu  Glu Leu Tyr 
    1415                 1420                 1425             


Cys Pro  Pro Ile Thr Val Lys  Val Ile Asp Asn Arg  Gln Phe Gly 
    1430                 1435                 1440             


Arg Arg  Pro Val Val Gly Gln  Cys Thr Ile Arg Ser  Leu Glu Ser 
    1445                 1450                 1455             


Phe Leu  Cys Asp Pro Tyr Ser  Ala Glu Ser Pro Ser  Pro Gln Gly 
    1460                 1465                 1470             


Gly Pro  Asp Asp Val Ser Leu  Leu Ser Pro Gly Glu  Asp Val Leu 
    1475                 1480                 1485             


Ile Asp  Ile Asp Asp Lys Glu  Pro Leu Ile Pro Ile  Gln Glu Glu 
    1490                 1495                 1500             


Glu Phe  Ile Asp Trp Trp Ser  Lys Phe Phe Ala Ser  Ile Gly Glu 
    1505                 1510                 1515             


Arg Glu  Lys Cys Gly Ser Tyr  Leu Glu Lys Asp Phe  Asp Thr Leu 
    1520                 1525                 1530             


Lys Val  Tyr Asp Thr Gln Leu  Glu Asn Val Glu Ala  Phe Glu Gly 
    1535                 1540                 1545             


Leu Ser  Asp Phe Cys Asn Thr  Phe Lys Leu Tyr Arg  Gly Lys Thr 
    1550                 1555                 1560             


Gln Glu  Glu Thr Glu Asp Pro  Ser Val Ile Gly Glu  Phe Lys Gly 
    1565                 1570                 1575             


Leu Phe  Lys Ile Tyr Pro Leu  Pro Glu Asp Pro Ala  Ile Pro Met 
    1580                 1585                 1590             


Pro Pro  Arg Gln Phe His Gln  Leu Ala Ala Gln Gly  Pro Gln Glu 
    1595                 1600                 1605             


Cys Leu  Val Arg Ile Tyr Ile  Val Arg Ala Phe Gly  Leu Gln Pro 
    1610                 1615                 1620             


Lys Asp  Pro Asn Gly Lys Cys  Asp Pro Tyr Ile Lys  Ile Ser Ile 
    1625                 1630                 1635             


Gly Lys  Lys Ser Val Ser Asp  Gln Asp Asn Tyr Ile  Pro Cys Thr 
    1640                 1645                 1650             


Leu Glu  Pro Val Phe Gly Lys  Met Phe Glu Leu Thr  Cys Thr Leu 
    1655                 1660                 1665             


Pro Leu  Glu Lys Asp Leu Lys  Ile Thr Leu Tyr Asp  Tyr Asp Leu 
    1670                 1675                 1680             


Leu Ser  Lys Asp Glu Lys Ile  Gly Glu Thr Val Val  Asp Leu Glu 
    1685                 1690                 1695             


Asn Arg  Leu Leu Ser Lys Phe  Gly Ala Arg Cys Gly  Leu Pro Gln 
    1700                 1705                 1710             


Thr Tyr  Cys Val Ser Gly Pro  Asn Gln Trp Arg Asp  Gln Leu Arg 
    1715                 1720                 1725             


Pro Ser  Gln Leu Leu His Leu  Phe Cys Gln Gln His  Arg Val Lys 
    1730                 1735                 1740             


Ala Pro  Val Tyr Arg Thr Asp  Arg Val Met Phe Gln  Asp Lys Glu 
    1745                 1750                 1755             


Tyr Ser  Ile Glu Glu Ile Glu  Ala Gly Arg Ile Pro  Asn Pro His 
    1760                 1765                 1770             


Leu Gly  Pro Val Glu Glu Arg  Leu Ala Leu His Val  Leu Gln Gln 
    1775                 1780                 1785             


Gln Gly  Leu Val Pro Glu His  Val Glu Ser Arg Pro  Leu Tyr Ser 
    1790                 1795                 1800             


Pro Leu  Gln Pro Asp Ile Glu  Gln Gly Lys Leu Gln  Met Trp Val 
    1805                 1810                 1815             


Asp Leu  Phe Pro Lys Ala Leu  Gly Arg Pro Gly Pro  Pro Phe Asn 
    1820                 1825                 1830             


Ile Thr  Pro Arg Arg Ala Arg  Arg Phe Phe Leu Arg  Cys Ile Ile 
    1835                 1840                 1845             


Trp Asn  Thr Arg Asp Val Ile  Leu Asp Asp Leu Ser  Leu Thr Gly 
    1850                 1855                 1860             


Glu Lys  Met Ser Asp Ile Tyr  Val Lys Gly Trp Met  Ile Gly Phe 
    1865                 1870                 1875             


Glu Glu  His Lys Gln Lys Thr  Asp Val His Tyr Arg  Ser Leu Gly 
    1880                 1885                 1890             


Gly Glu  Gly Asn Phe Asn Trp  Arg Phe Ile Phe Pro  Phe Asp Tyr 
    1895                 1900                 1905             


Leu Pro  Ala Glu Gln Val Cys  Thr Ile Ala Lys Lys  Asp Ala Phe 
    1910                 1915                 1920             


Trp Arg  Leu Asp Lys Thr Glu  Ser Lys Ile Pro Ala  Arg Val Val 
    1925                 1930                 1935             


Phe Gln  Ile Trp Asp Asn Asp  Lys Phe Ser Phe Asp  Asp Phe Leu 
    1940                 1945                 1950             


Gly Ser  Leu Gln Leu Asp Leu  Asn Arg Met Pro Lys  Pro Ala Lys 
    1955                 1960                 1965             


Thr Ala  Lys Lys Cys Ser Leu  Asp Gln Leu Asp Asp  Ala Phe His 
    1970                 1975                 1980             


Pro Glu  Trp Phe Val Ser Leu  Phe Glu Gln Lys Thr  Val Lys Gly 
    1985                 1990                 1995             


Trp Trp  Pro Cys Val Ala Glu  Glu Gly Glu Lys Lys  Ile Leu Ala 
    2000                 2005                 2010             


Gly Lys  Leu Glu Met Thr Leu  Glu Ile Val Ala Glu  Ser Glu His 
    2015                 2020                 2025             


Glu Glu  Arg Pro Ala Gly Gln  Gly Arg Asp Glu Pro  Asn Met Asn 
    2030                 2035                 2040             


Pro Lys  Leu Glu Asp Pro Arg  Arg Pro Asp Thr Ser  Phe Leu Trp 
    2045                 2050                 2055             


Phe Thr  Ser Pro Tyr Lys Thr  Met Lys Phe Ile Leu  Trp Arg Arg 
    2060                 2065                 2070             


Phe Arg  Trp Ala Ile Ile Leu  Phe Ile Ile Leu Phe  Ile Leu Leu 
    2075                 2080                 2085             


Leu Phe  Leu Ala Ile Phe Ile  Tyr Ala Phe Pro Asn  Tyr Ala Ala 
    2090                 2095                 2100             


Met Lys  Leu Val Lys Pro Phe  Ser 
    2105                 2110     


<210>  1457
<211>  2097
<212>  PRT
<213>  Homo sapiens

<400>  1457

Met Leu Arg Val Phe Ile Leu Tyr Ala Glu Asn Val His Thr Pro Asp 
1               5                   10                  15      


Thr Asp Ile Ser Asp Ala Tyr Cys Ser Ala Val Phe Ala Gly Val Lys 
            20                  25                  30          


Lys Arg Thr Lys Val Ile Lys Asn Ser Val Asn Pro Val Trp Asn Glu 
        35                  40                  45              


Gly Phe Glu Trp Asp Leu Lys Gly Ile Pro Leu Asp Gln Gly Ser Glu 
    50                  55                  60                  


Leu His Val Val Val Lys Asp His Glu Thr Met Gly Arg Asn Arg Phe 
65                  70                  75                  80  


Leu Gly Glu Ala Lys Val Pro Leu Arg Glu Val Leu Ala Thr Pro Ser 
                85                  90                  95      


Leu Ser Ala Ser Phe Asn Ala Pro Leu Leu Asp Thr Lys Lys Gln Pro 
            100                 105                 110         


Thr Gly Ala Ser Leu Val Leu Gln Val Ser Tyr Thr Pro Leu Pro Gly 
        115                 120                 125             


Ala Val Pro Leu Phe Pro Pro Pro Thr Pro Leu Glu Pro Ser Pro Thr 
    130                 135                 140                 


Leu Pro Asp Leu Asp Val Val Ala Gly Gly Gly Gln Ser Arg Ala Glu 
145                 150                 155                 160 


Thr Trp Ser Leu Leu Ser Asp Ser Thr Met Asp Thr Arg Tyr Ser Gly 
                165                 170                 175     


Lys Lys Trp Pro Ala Pro Thr Asp Thr Gly Gly Glu Glu Asp Thr Glu 
            180                 185                 190         


Asp Gln Gly Leu Thr Gly Asp Glu Ala Glu Pro Phe Leu Asp Gln Ser 
        195                 200                 205             


Gly Gly Pro Gly Ala Pro Thr Thr Pro Arg Lys Leu Pro Ser Arg Pro 
    210                 215                 220                 


Pro Pro His Tyr Pro Gly Ile Lys Arg Lys Arg Ser Ala Pro Thr Ser 
225                 230                 235                 240 


Arg Lys Leu Leu Ser Asp Lys Pro Gln Asp Phe Gln Ile Arg Val Gln 
                245                 250                 255     


Val Ile Glu Gly Arg Gln Leu Pro Gly Val Asn Ile Lys Pro Val Val 
            260                 265                 270         


Lys Val Thr Ala Ala Gly Gln Thr Lys Arg Thr Arg Ile His Lys Gly 
        275                 280                 285             


Asn Ser Pro Leu Phe Asn Glu Thr Leu Phe Phe Asn Leu Phe Asp Ser 
    290                 295                 300                 


Pro Gly Glu Leu Phe Asp Glu Pro Ile Phe Ile Thr Val Val Asp Ser 
305                 310                 315                 320 


Arg Ser Leu Arg Thr Asp Ala Leu Leu Gly Glu Phe Arg Met Asp Val 
                325                 330                 335     


Gly Thr Ile Tyr Arg Glu Pro Arg His Ala Tyr Leu Arg Lys Trp Leu 
            340                 345                 350         


Leu Leu Ser Asp Pro Asp Asp Phe Ser Ala Gly Ala Arg Gly Tyr Leu 
        355                 360                 365             


Lys Thr Ser Leu Cys Val Leu Gly Pro Gly Asp Glu Ala Pro Leu Glu 
    370                 375                 380                 


Arg Lys Asp Pro Ser Glu Asp Lys Glu Asp Ile Glu Ser Asn Leu Leu 
385                 390                 395                 400 


Arg Pro Thr Gly Val Ala Leu Arg Gly Ala His Phe Cys Leu Lys Val 
                405                 410                 415     


Phe Arg Ala Glu Asp Leu Pro Gln Met Asp Asp Ala Val Met Asp Asn 
            420                 425                 430         


Val Lys Gln Ile Phe Gly Phe Glu Ser Asn Lys Lys Asn Leu Val Asp 
        435                 440                 445             


Pro Phe Val Glu Val Ser Phe Ala Gly Lys Met Leu Cys Ser Lys Ile 
    450                 455                 460                 


Leu Glu Lys Thr Ala Asn Pro Gln Trp Asn Gln Asn Ile Thr Leu Pro 
465                 470                 475                 480 


Ala Met Phe Pro Ser Met Cys Glu Lys Met Arg Ile Arg Ile Ile Asp 
                485                 490                 495     


Trp Asp Arg Leu Thr His Asn Asp Ile Val Ala Thr Thr Tyr Leu Ser 
            500                 505                 510         


Met Ser Lys Ile Ser Ala Pro Gly Gly Glu Ile Glu Val Asp Asp Tyr 
        515                 520                 525             


Leu Gly Phe Leu Pro Thr Phe Gly Pro Cys Tyr Ile Asn Leu Tyr Gly 
    530                 535                 540                 


Ser Pro Arg Glu Phe Thr Gly Phe Pro Asp Pro Tyr Thr Glu Leu Asn 
545                 550                 555                 560 


Thr Gly Lys Gly Glu Gly Val Ala Tyr Arg Gly Arg Leu Leu Leu Ser 
                565                 570                 575     


Leu Glu Thr Lys Leu Val Glu His Ser Glu Gln Lys Val Glu Asp Leu 
            580                 585                 590         


Pro Ala Asp Asp Ile Leu Arg Val Glu Lys Tyr Leu Arg Arg Arg Lys 
        595                 600                 605             


Tyr Ser Leu Phe Ala Ala Phe Tyr Ser Ala Thr Met Leu Gln Asp Val 
    610                 615                 620                 


Asp Asp Ala Ile Gln Phe Glu Val Ser Ile Gly Asn Tyr Gly Asn Lys 
625                 630                 635                 640 


Phe Asp Met Thr Cys Leu Pro Leu Ala Ser Thr Thr Gln Tyr Ser Arg 
                645                 650                 655     


Ala Val Phe Asp Gly Cys His Tyr Tyr Tyr Leu Pro Trp Gly Asn Val 
            660                 665                 670         


Lys Pro Val Val Val Leu Ser Ser Tyr Trp Glu Asp Ile Ser His Arg 
        675                 680                 685             


Ile Glu Thr Gln Asn Gln Leu Leu Gly Ile Ala Asp Arg Leu Glu Ala 
    690                 695                 700                 


Gly Leu Glu Gln Val His Leu Ala Leu Lys Ala Gln Cys Ser Thr Glu 
705                 710                 715                 720 


Asp Val Asp Ser Leu Val Ala Gln Leu Thr Asp Glu Leu Ile Ala Gly 
                725                 730                 735     


Cys Ser Gln Pro Leu Gly Asp Ile His Glu Thr Pro Ser Ala Thr His 
            740                 745                 750         


Leu Asp Gln Tyr Leu Tyr Gln Leu Arg Thr His His Leu Ser Gln Ile 
        755                 760                 765             


Thr Glu Ala Ala Leu Ala Leu Lys Leu Gly His Ser Glu Leu Pro Ala 
    770                 775                 780                 


Ala Leu Glu Gln Ala Glu Asp Trp Leu Leu Arg Leu Arg Ala Leu Ala 
785                 790                 795                 800 


Glu Glu Pro Gln Asn Ser Leu Pro Asp Ile Val Ile Trp Met Leu Gln 
                805                 810                 815     


Gly Asp Lys Arg Val Ala Tyr Gln Arg Val Pro Ala His Gln Val Leu 
            820                 825                 830         


Phe Ser Arg Arg Gly Ala Asn Tyr Cys Gly Lys Asn Cys Gly Lys Leu 
        835                 840                 845             


Gln Thr Ile Phe Leu Lys Tyr Pro Met Glu Lys Val Pro Gly Ala Arg 
    850                 855                 860                 


Met Pro Val Gln Ile Arg Val Lys Leu Trp Phe Gly Leu Ser Val Asp 
865                 870                 875                 880 


Glu Lys Glu Phe Asn Gln Phe Ala Glu Gly Lys Leu Ser Val Phe Ala 
                885                 890                 895     


Glu Thr Tyr Glu Asn Glu Thr Lys Leu Ala Leu Val Gly Asn Trp Gly 
            900                 905                 910         


Thr Thr Gly Leu Thr Tyr Pro Lys Phe Ser Asp Val Thr Gly Lys Ile 
        915                 920                 925             


Lys Leu Pro Lys Asp Ser Phe Arg Pro Ser Ala Gly Trp Thr Trp Ala 
    930                 935                 940                 


Gly Asp Trp Phe Val Cys Pro Glu Lys Thr Leu Leu His Asp Met Asp 
945                 950                 955                 960 


Ala Gly His Leu Ser Phe Val Glu Glu Val Phe Glu Asn Gln Thr Arg 
                965                 970                 975     


Leu Pro Gly Gly Gln Trp Ile Tyr Met Ser Asp Asn Tyr Thr Asp Val 
            980                 985                 990         


Asn Gly Glu Lys Val Leu Pro Lys  Asp Asp Ile Glu Cys  Pro Leu Gly 
        995                 1000                 1005             


Trp Lys  Trp Glu Asp Glu Glu  Trp Ser Thr Asp Leu  Asn Arg Ala 
    1010                 1015                 1020             


Val Asp  Glu Gln Gly Trp Glu  Tyr Ser Ile Thr Ile  Pro Pro Glu 
    1025                 1030                 1035             


Arg Lys  Pro Lys His Trp Val  Pro Ala Glu Lys Met  Tyr Tyr Thr 
    1040                 1045                 1050             


His Arg  Arg Arg Arg Trp Val  Arg Leu Arg Arg Arg  Asp Leu Ser 
    1055                 1060                 1065             


Gln Met  Glu Ala Leu Lys Arg  His Arg Gln Ala Glu  Ala Glu Gly 
    1070                 1075                 1080             


Glu Gly  Trp Glu Tyr Ala Ser  Leu Phe Gly Trp Lys  Phe His Leu 
    1085                 1090                 1095             


Glu Tyr  Arg Lys Thr Asp Ala  Phe Arg Arg Arg Arg  Trp Arg Arg 
    1100                 1105                 1110             


Arg Met  Glu Pro Leu Glu Lys  Thr Gly Pro Ala Ala  Val Phe Ala 
    1115                 1120                 1125             


Leu Glu  Gly Ala Leu Gly Gly  Val Met Asp Asp Lys  Ser Glu Asp 
    1130                 1135                 1140             


Ser Met  Ser Val Ser Thr Leu  Ser Phe Gly Val Asn  Arg Pro Thr 
    1145                 1150                 1155             


Ile Ser  Cys Ile Phe Asp Tyr  Gly Asn Arg Tyr His  Leu Arg Cys 
    1160                 1165                 1170             


Tyr Met  Tyr Gln Ala Arg Asp  Leu Ala Ala Met Asp  Lys Asp Ser 
    1175                 1180                 1185             


Phe Ser  Asp Pro Tyr Ala Ile  Val Ser Phe Leu His  Gln Ser Gln 
    1190                 1195                 1200             


Lys Thr  Val Val Val Lys Asn  Thr Leu Asn Pro Thr  Trp Asp Gln 
    1205                 1210                 1215             


Thr Leu  Ile Phe Tyr Glu Ile  Glu Ile Phe Gly Glu  Pro Ala Thr 
    1220                 1225                 1230             


Val Ala  Glu Gln Pro Pro Ser  Ile Val Val Glu Leu  Tyr Asp His 
    1235                 1240                 1245             


Asp Thr  Tyr Gly Ala Asp Glu  Phe Met Gly Arg Cys  Ile Cys Gln 
    1250                 1255                 1260             


Pro Ser  Leu Glu Arg Met Pro  Arg Leu Ala Trp Phe  Pro Leu Thr 
    1265                 1270                 1275             


Arg Gly  Ser Gln Pro Ser Gly  Glu Leu Leu Ala Ser  Phe Glu Leu 
    1280                 1285                 1290             


Ile Gln  Arg Glu Lys Pro Ala  Ile His His Ile Pro  Gly Phe Glu 
    1295                 1300                 1305             


Val Gln  Glu Thr Ser Arg Ile  Leu Asp Glu Ser Glu  Asp Thr Asp 
    1310                 1315                 1320             


Leu Pro  Tyr Pro Pro Pro Gln  Arg Glu Ala Asn Ile  Tyr Met Val 
    1325                 1330                 1335             


Pro Gln  Asn Ile Lys Pro Ala  Leu Gln Arg Thr Ala  Ile Glu Ile 
    1340                 1345                 1350             


Leu Ala  Trp Gly Leu Arg Asn  Met Lys Ser Tyr Gln  Leu Ala Asn 
    1355                 1360                 1365             


Ile Ser  Ser Pro Ser Leu Val  Val Glu Cys Gly Gly  Gln Thr Val 
    1370                 1375                 1380             


Gln Ser  Cys Val Ile Arg Asn  Leu Arg Lys Asn Pro  Asn Phe Asp 
    1385                 1390                 1395             


Ile Cys  Thr Leu Phe Met Glu  Val Met Leu Pro Arg  Glu Glu Leu 
    1400                 1405                 1410             


Tyr Cys  Pro Pro Ile Thr Val  Lys Val Ile Asp Asn  Arg Gln Phe 
    1415                 1420                 1425             


Gly Arg  Arg Pro Val Val Gly  Gln Cys Thr Ile Arg  Ser Leu Glu 
    1430                 1435                 1440             


Ser Phe  Leu Cys Asp Pro Tyr  Ser Ala Glu Ser Pro  Ser Pro Gln 
    1445                 1450                 1455             


Gly Gly  Pro Asp Asp Val Ser  Leu Leu Ser Pro Gly  Glu Asp Val 
    1460                 1465                 1470             


Leu Ile  Asp Ile Asp Asp Lys  Glu Pro Leu Ile Pro  Ile Gln Glu 
    1475                 1480                 1485             


Glu Glu  Phe Ile Asp Trp Trp  Ser Lys Phe Phe Ala  Ser Ile Gly 
    1490                 1495                 1500             


Glu Arg  Glu Lys Cys Gly Ser  Tyr Leu Glu Lys Asp  Phe Asp Thr 
    1505                 1510                 1515             


Leu Lys  Val Tyr Asp Thr Gln  Leu Glu Asn Val Glu  Ala Phe Glu 
    1520                 1525                 1530             


Gly Leu  Ser Asp Phe Cys Asn  Thr Phe Lys Leu Tyr  Arg Gly Lys 
    1535                 1540                 1545             


Thr Gln  Glu Glu Thr Glu Asp  Pro Ser Val Ile Gly  Glu Phe Lys 
    1550                 1555                 1560             


Gly Leu  Phe Lys Ile Tyr Pro  Leu Pro Glu Asp Pro  Ala Ile Pro 
    1565                 1570                 1575             


Met Pro  Pro Arg Gln Phe His  Gln Leu Ala Ala Gln  Gly Pro Gln 
    1580                 1585                 1590             


Glu Cys  Leu Val Arg Ile Tyr  Ile Val Arg Ala Phe  Gly Leu Gln 
    1595                 1600                 1605             


Pro Lys  Asp Pro Asn Gly Lys  Cys Asp Pro Tyr Ile  Lys Ile Ser 
    1610                 1615                 1620             


Ile Gly  Lys Lys Ser Val Ser  Asp Gln Asp Asn Tyr  Ile Pro Cys 
    1625                 1630                 1635             


Thr Leu  Glu Pro Val Phe Gly  Lys Met Phe Glu Leu  Thr Cys Thr 
    1640                 1645                 1650             


Leu Pro  Leu Glu Lys Asp Leu  Lys Ile Thr Leu Tyr  Asp Tyr Asp 
    1655                 1660                 1665             


Leu Leu  Ser Lys Asp Glu Lys  Ile Gly Glu Thr Val  Val Asp Leu 
    1670                 1675                 1680             


Glu Asn  Arg Leu Leu Ser Lys  Phe Gly Ala Arg Cys  Gly Leu Pro 
    1685                 1690                 1695             


Gln Thr  Tyr Cys Val Ser Gly  Pro Asn Gln Trp Arg  Asp Gln Leu 
    1700                 1705                 1710             


Arg Pro  Ser Gln Leu Leu His  Leu Phe Cys Gln Gln  His Arg Val 
    1715                 1720                 1725             


Lys Ala  Pro Val Tyr Arg Thr  Asp Arg Val Met Phe  Gln Asp Lys 
    1730                 1735                 1740             


Glu Tyr  Ser Ile Glu Glu Ile  Glu Ala Gly Arg Ile  Pro Asn Pro 
    1745                 1750                 1755             


His Leu  Gly Pro Val Glu Glu  Arg Leu Ala Leu His  Val Leu Gln 
    1760                 1765                 1770             


Gln Gln  Gly Leu Val Pro Glu  His Val Glu Ser Arg  Pro Leu Tyr 
    1775                 1780                 1785             


Ser Pro  Leu Gln Pro Asp Ile  Glu Gln Gly Lys Leu  Gln Met Trp 
    1790                 1795                 1800             


Val Asp  Leu Phe Pro Lys Ala  Leu Gly Arg Pro Gly  Pro Pro Phe 
    1805                 1810                 1815             


Asn Ile  Thr Pro Arg Arg Ala  Arg Arg Phe Phe Leu  Arg Cys Ile 
    1820                 1825                 1830             


Ile Trp  Asn Thr Arg Asp Val  Ile Leu Asp Asp Leu  Ser Leu Thr 
    1835                 1840                 1845             


Gly Glu  Lys Met Ser Asp Ile  Tyr Val Lys Gly Trp  Met Ile Gly 
    1850                 1855                 1860             


Phe Glu  Glu His Lys Gln Lys  Thr Asp Val His Tyr  Arg Ser Leu 
    1865                 1870                 1875             


Gly Gly  Glu Gly Asn Phe Asn  Trp Arg Phe Ile Phe  Pro Phe Asp 
    1880                 1885                 1890             


Tyr Leu  Pro Ala Glu Gln Val  Cys Thr Ile Ala Lys  Lys Asp Ala 
    1895                 1900                 1905             


Phe Trp  Arg Leu Asp Lys Thr  Glu Ser Lys Ile Pro  Ala Arg Val 
    1910                 1915                 1920             


Val Phe  Gln Ile Trp Asp Asn  Asp Lys Phe Ser Phe  Asp Asp Phe 
    1925                 1930                 1935             


Leu Gly  Ser Leu Gln Leu Asp  Leu Asn Arg Met Pro  Lys Pro Ala 
    1940                 1945                 1950             


Lys Thr  Ala Lys Lys Cys Ser  Leu Asp Gln Leu Asp  Asp Ala Phe 
    1955                 1960                 1965             


His Pro  Glu Trp Phe Val Ser  Leu Phe Glu Gln Lys  Thr Val Lys 
    1970                 1975                 1980             


Gly Trp  Trp Pro Cys Val Ala  Glu Glu Gly Glu Lys  Lys Ile Leu 
    1985                 1990                 1995             


Ala Gly  Lys Leu Glu Met Thr  Leu Glu Ile Val Ala  Glu Ser Glu 
    2000                 2005                 2010             


His Glu  Glu Arg Pro Ala Gly  Gln Gly Arg Asp Glu  Pro Asn Met 
    2015                 2020                 2025             


Asn Pro  Lys Leu Glu Asp Pro  Arg Arg Pro Asp Thr  Ser Phe Leu 
    2030                 2035                 2040             


Trp Phe  Thr Ser Pro Tyr Lys  Thr Met Lys Phe Ile  Leu Trp Arg 
    2045                 2050                 2055             


Arg Phe  Arg Trp Ala Ile Ile  Leu Phe Ile Ile Leu  Phe Ile Leu 
    2060                 2065                 2070             


Leu Leu  Phe Leu Ala Ile Phe  Ile Tyr Ala Phe Pro  Asn Tyr Ala 
    2075                 2080                 2085             


Ala Met  Lys Leu Val Lys Pro  Phe Ser 
    2090                 2095         


<210>  1458
<211>  2118
<212>  PRT
<213>  Homo sapiens

<400>  1458

Met Leu Arg Val Phe Ile Leu Tyr Ala Glu Asn Val His Thr Pro Asp 
1               5                   10                  15      


Thr Asp Ile Ser Asp Ala Tyr Cys Ser Ala Val Phe Ala Gly Val Lys 
            20                  25                  30          


Lys Arg Thr Lys Val Ile Lys Asn Ser Val Asn Pro Val Trp Asn Glu 
        35                  40                  45              


Gly Phe Glu Trp Asp Leu Lys Gly Ile Pro Leu Asp Gln Gly Ser Glu 
    50                  55                  60                  


Leu His Val Val Val Lys Asp His Glu Thr Met Gly Arg Asn Arg Phe 
65                  70                  75                  80  


Leu Gly Glu Ala Lys Val Pro Leu Arg Glu Val Leu Ala Thr Pro Ser 
                85                  90                  95      


Leu Ser Ala Ser Phe Asn Ala Pro Leu Leu Asp Thr Lys Lys Gln Pro 
            100                 105                 110         


Thr Gly Ala Ser Leu Val Leu Gln Val Ser Tyr Thr Pro Leu Pro Gly 
        115                 120                 125             


Ala Val Pro Leu Phe Pro Pro Pro Thr Pro Leu Glu Pro Ser Pro Thr 
    130                 135                 140                 


Leu Pro Asp Leu Asp Val Val Ala Gly Gly Gly Gln Ser Arg Ala Glu 
145                 150                 155                 160 


Thr Trp Ser Leu Leu Ser Asp Ser Thr Met Asp Thr Arg Tyr Ser Gly 
                165                 170                 175     


Lys Lys Trp Pro Ala Pro Thr Asp Thr Gly Gly Glu Glu Asp Thr Glu 
            180                 185                 190         


Asp Gln Gly Leu Thr Gly Asp Glu Ala Glu Pro Phe Leu Asp Gln Ser 
        195                 200                 205             


Gly Gly Pro Gly Ala Pro Thr Thr Pro Arg Lys Leu Pro Ser Arg Pro 
    210                 215                 220                 


Pro Pro His Tyr Pro Gly Ile Lys Arg Lys Arg Ser Ala Pro Thr Ser 
225                 230                 235                 240 


Arg Lys Leu Leu Ser Asp Lys Pro Gln Asp Phe Gln Ile Arg Val Gln 
                245                 250                 255     


Val Ile Glu Gly Arg Gln Leu Pro Gly Val Asn Ile Lys Pro Val Val 
            260                 265                 270         


Lys Val Thr Ala Ala Gly Gln Thr Lys Arg Thr Arg Ile His Lys Gly 
        275                 280                 285             


Asn Ser Pro Leu Phe Asn Glu Thr Leu Phe Phe Asn Leu Phe Asp Ser 
    290                 295                 300                 


Pro Gly Glu Leu Phe Asp Glu Pro Ile Phe Ile Thr Val Val Asp Ser 
305                 310                 315                 320 


Arg Ser Leu Arg Thr Asp Ala Leu Leu Gly Glu Phe Arg Met Asp Val 
                325                 330                 335     


Gly Thr Ile Tyr Arg Glu Pro Arg His Ala Tyr Leu Arg Lys Trp Leu 
            340                 345                 350         


Leu Leu Ser Asp Pro Asp Asp Phe Ser Ala Gly Ala Arg Gly Tyr Leu 
        355                 360                 365             


Lys Thr Ser Leu Cys Val Leu Gly Pro Gly Asp Glu Ala Pro Leu Glu 
    370                 375                 380                 


Arg Lys Asp Pro Ser Glu Asp Lys Glu Asp Ile Glu Ser Asn Leu Leu 
385                 390                 395                 400 


Arg Pro Thr Gly Val Ala Leu Arg Gly Ala His Phe Cys Leu Lys Val 
                405                 410                 415     


Phe Arg Ala Glu Asp Leu Pro Gln Met Asp Asp Ala Val Met Asp Asn 
            420                 425                 430         


Val Lys Gln Ile Phe Gly Phe Glu Ser Asn Lys Lys Asn Leu Val Asp 
        435                 440                 445             


Pro Phe Val Glu Val Ser Phe Ala Gly Lys Met Leu Cys Ser Lys Ile 
    450                 455                 460                 


Leu Glu Lys Thr Ala Asn Pro Gln Trp Asn Gln Asn Ile Thr Leu Pro 
465                 470                 475                 480 


Ala Met Phe Pro Ser Met Cys Glu Lys Met Arg Ile Arg Ile Ile Asp 
                485                 490                 495     


Trp Asp Arg Leu Thr His Asn Asp Ile Val Ala Thr Thr Tyr Leu Ser 
            500                 505                 510         


Met Ser Lys Ile Ser Ala Pro Gly Gly Glu Ile Glu Val Asp Asp Tyr 
        515                 520                 525             


Leu Gly Phe Leu Pro Thr Phe Gly Pro Cys Tyr Ile Asn Leu Tyr Gly 
    530                 535                 540                 


Ser Pro Arg Glu Phe Thr Gly Phe Pro Asp Pro Tyr Thr Glu Leu Asn 
545                 550                 555                 560 


Thr Gly Lys Gly Glu Gly Val Ala Tyr Arg Gly Arg Leu Leu Leu Ser 
                565                 570                 575     


Leu Glu Thr Lys Leu Val Glu His Ser Glu Gln Lys Val Glu Asp Leu 
            580                 585                 590         


Pro Ala Asp Asp Ile Leu Arg Val Glu Lys Tyr Leu Arg Arg Arg Lys 
        595                 600                 605             


Tyr Ser Leu Phe Ala Ala Phe Tyr Ser Ala Thr Met Leu Gln Asp Val 
    610                 615                 620                 


Asp Asp Ala Ile Gln Phe Glu Val Ser Ile Gly Asn Tyr Gly Asn Lys 
625                 630                 635                 640 


Phe Asp Met Thr Cys Leu Pro Leu Ala Ser Thr Thr Gln Tyr Ser Arg 
                645                 650                 655     


Ala Val Phe Asp Gly Cys His Tyr Tyr Tyr Leu Pro Trp Gly Asn Val 
            660                 665                 670         


Lys Pro Val Val Val Leu Ser Ser Tyr Trp Glu Asp Ile Ser His Arg 
        675                 680                 685             


Ile Glu Thr Gln Asn Gln Leu Leu Gly Ile Ala Asp Arg Leu Glu Ala 
    690                 695                 700                 


Gly Leu Glu Gln Val His Leu Ala Leu Lys Ala Gln Cys Ser Thr Glu 
705                 710                 715                 720 


Asp Val Asp Ser Leu Val Ala Gln Leu Thr Asp Glu Leu Ile Ala Gly 
                725                 730                 735     


Cys Ser Gln Pro Leu Gly Asp Ile His Glu Thr Pro Ser Ala Thr His 
            740                 745                 750         


Leu Asp Gln Tyr Leu Tyr Gln Leu Arg Thr His His Leu Ser Gln Ile 
        755                 760                 765             


Thr Glu Ala Ala Leu Ala Leu Lys Leu Gly His Ser Glu Leu Pro Ala 
    770                 775                 780                 


Ala Leu Glu Gln Ala Glu Asp Trp Leu Leu Arg Leu Arg Ala Leu Ala 
785                 790                 795                 800 


Glu Glu Pro Gln Asn Ser Leu Pro Asp Ile Val Ile Trp Met Leu Gln 
                805                 810                 815     


Gly Asp Lys Arg Val Ala Tyr Gln Arg Val Pro Ala His Gln Val Leu 
            820                 825                 830         


Phe Ser Arg Arg Gly Ala Asn Tyr Cys Gly Lys Asn Cys Gly Lys Leu 
        835                 840                 845             


Gln Thr Ile Phe Leu Lys Tyr Pro Met Glu Lys Val Pro Gly Ala Arg 
    850                 855                 860                 


Met Pro Val Gln Ile Arg Val Lys Leu Trp Phe Gly Leu Ser Val Asp 
865                 870                 875                 880 


Glu Lys Glu Phe Asn Gln Phe Ala Glu Gly Lys Leu Ser Val Phe Ala 
                885                 890                 895     


Glu Thr Tyr Glu Asn Glu Thr Lys Leu Ala Leu Val Gly Asn Trp Gly 
            900                 905                 910         


Thr Thr Gly Leu Thr Tyr Pro Lys Phe Ser Asp Val Thr Gly Lys Ile 
        915                 920                 925             


Lys Leu Pro Lys Asp Ser Phe Arg Pro Ser Ala Gly Trp Thr Trp Ala 
    930                 935                 940                 


Gly Asp Trp Phe Val Cys Pro Glu Lys Thr Leu Leu His Asp Met Asp 
945                 950                 955                 960 


Ala Gly His Leu Ser Phe Val Glu Glu Val Phe Glu Asn Gln Thr Arg 
                965                 970                 975     


Leu Pro Gly Gly Gln Trp Ile Tyr Met Ser Asp Asn Tyr Thr Asp Val 
            980                 985                 990         


Asn Gly Glu Lys Val Leu Pro Lys  Asp Asp Ile Glu Cys  Pro Leu Gly 
        995                 1000                 1005             


Trp Lys  Trp Glu Asp Glu Glu  Trp Ser Thr Asp Leu  Asn Arg Ala 
    1010                 1015                 1020             


Val Asp  Glu Gln Gly Trp Glu  Tyr Ser Ile Thr Ile  Pro Pro Glu 
    1025                 1030                 1035             


Arg Lys  Pro Lys His Trp Val  Pro Ala Glu Lys Met  Tyr Tyr Thr 
    1040                 1045                 1050             


His Arg  Arg Arg Arg Trp Val  Arg Leu Arg Arg Arg  Asp Leu Ser 
    1055                 1060                 1065             


Gln Met  Glu Ala Leu Lys Arg  His Arg Gln Ala Glu  Ala Glu Gly 
    1070                 1075                 1080             


Glu Gly  Trp Glu Tyr Ala Ser  Leu Phe Gly Trp Lys  Phe His Leu 
    1085                 1090                 1095             


Glu Tyr  Arg Lys Thr Asp Ala  Phe Arg Arg Arg Arg  Trp Arg Arg 
    1100                 1105                 1110             


Arg Met  Glu Pro Leu Glu Lys  Thr Gly Pro Ala Ala  Val Phe Ala 
    1115                 1120                 1125             


Leu Glu  Gly Ala Leu Gly Gly  Val Met Asp Asp Lys  Ser Glu Asp 
    1130                 1135                 1140             


Ser Met  Ser Val Ser Thr Leu  Ser Phe Gly Val Asn  Arg Pro Thr 
    1145                 1150                 1155             


Ile Ser  Cys Ile Phe Asp Tyr  Gly Asn Arg Tyr His  Leu Arg Cys 
    1160                 1165                 1170             


Tyr Met  Tyr Gln Ala Arg Asp  Leu Ala Ala Met Asp  Lys Asp Ser 
    1175                 1180                 1185             


Phe Ser  Asp Pro Tyr Ala Ile  Val Ser Phe Leu His  Gln Ser Gln 
    1190                 1195                 1200             


Lys Thr  Val Val Val Lys Asn  Thr Leu Asn Pro Thr  Trp Asp Gln 
    1205                 1210                 1215             


Thr Leu  Ile Phe Tyr Glu Ile  Glu Ile Phe Gly Glu  Pro Ala Thr 
    1220                 1225                 1230             


Val Ala  Glu Gln Pro Pro Ser  Ile Val Val Glu Leu  Tyr Asp His 
    1235                 1240                 1245             


Asp Thr  Tyr Gly Ala Asp Glu  Phe Met Gly Arg Cys  Ile Cys Gln 
    1250                 1255                 1260             


Pro Ser  Leu Glu Arg Met Pro  Arg Leu Ala Trp Phe  Pro Leu Thr 
    1265                 1270                 1275             


Arg Gly  Ser Gln Pro Ser Gly  Glu Leu Leu Ala Ser  Phe Glu Leu 
    1280                 1285                 1290             


Ile Gln  Arg Glu Lys Pro Ala  Ile His His Ile Pro  Gly Phe Glu 
    1295                 1300                 1305             


Val Gln  Glu Thr Ser Arg Ile  Leu Asp Glu Ser Glu  Asp Thr Asp 
    1310                 1315                 1320             


Leu Pro  Tyr Pro Pro Pro Gln  Arg Glu Ala Asn Ile  Tyr Met Val 
    1325                 1330                 1335             


Pro Gln  Asn Ile Lys Pro Ala  Leu Gln Arg Thr Ala  Ile Glu Ile 
    1340                 1345                 1350             


Leu Ala  Trp Gly Leu Arg Asn  Met Lys Ser Tyr Gln  Leu Ala Asn 
    1355                 1360                 1365             


Ile Ser  Ser Pro Ser Leu Val  Val Glu Cys Gly Gly  Gln Thr Val 
    1370                 1375                 1380             


Gln Ser  Cys Val Ile Arg Asn  Leu Arg Lys Asn Pro  Asn Phe Asp 
    1385                 1390                 1395             


Ile Cys  Thr Leu Phe Met Glu  Val Met Leu Pro Arg  Glu Glu Leu 
    1400                 1405                 1410             


Tyr Cys  Pro Pro Ile Thr Val  Lys Val Ile Asp Asn  Arg Gln Phe 
    1415                 1420                 1425             


Gly Arg  Arg Pro Val Val Gly  Gln Cys Thr Ile Arg  Ser Leu Glu 
    1430                 1435                 1440             


Ser Phe  Leu Cys Asp Pro Tyr  Ser Ala Glu Ser Pro  Ser Pro Gln 
    1445                 1450                 1455             


Gly Gly  Pro Asp Asp Val Ser  Leu Leu Ser Pro Gly  Glu Asp Val 
    1460                 1465                 1470             


Leu Ile  Asp Ile Asp Asp Lys  Glu Pro Leu Ile Pro  Ile Gln Leu 
    1475                 1480                 1485             


Ala Asp  Gly Leu Ser Ser Leu  Ala Pro Thr Asn Thr  Ala Ser Pro 
    1490                 1495                 1500             


Pro Ser  Ser Pro His Glu Glu  Glu Phe Ile Asp Trp  Trp Ser Lys 
    1505                 1510                 1515             


Phe Phe  Ala Ser Ile Gly Glu  Arg Glu Lys Cys Gly  Ser Tyr Leu 
    1520                 1525                 1530             


Glu Lys  Asp Phe Asp Thr Leu  Lys Val Tyr Asp Thr  Gln Leu Glu 
    1535                 1540                 1545             


Asn Val  Glu Ala Phe Glu Gly  Leu Ser Asp Phe Cys  Asn Thr Phe 
    1550                 1555                 1560             


Lys Leu  Tyr Arg Gly Lys Thr  Gln Glu Glu Thr Glu  Asp Pro Ser 
    1565                 1570                 1575             


Val Ile  Gly Glu Phe Lys Gly  Leu Phe Lys Ile Tyr  Pro Leu Pro 
    1580                 1585                 1590             


Glu Asp  Pro Ala Ile Pro Met  Pro Pro Arg Gln Phe  His Gln Leu 
    1595                 1600                 1605             


Ala Ala  Gln Gly Pro Gln Glu  Cys Leu Val Arg Ile  Tyr Ile Val 
    1610                 1615                 1620             


Arg Ala  Phe Gly Leu Gln Pro  Lys Asp Pro Asn Gly  Lys Cys Asp 
    1625                 1630                 1635             


Pro Tyr  Ile Lys Ile Ser Ile  Gly Lys Lys Ser Val  Ser Asp Gln 
    1640                 1645                 1650             


Asp Asn  Tyr Ile Pro Cys Thr  Leu Glu Pro Val Phe  Gly Lys Met 
    1655                 1660                 1665             


Phe Glu  Leu Thr Cys Thr Leu  Pro Leu Glu Lys Asp  Leu Lys Ile 
    1670                 1675                 1680             


Thr Leu  Tyr Asp Tyr Asp Leu  Leu Ser Lys Asp Glu  Lys Ile Gly 
    1685                 1690                 1695             


Glu Thr  Val Val Asp Leu Glu  Asn Arg Leu Leu Ser  Lys Phe Gly 
    1700                 1705                 1710             


Ala Arg  Cys Gly Leu Pro Gln  Thr Tyr Cys Val Ser  Gly Pro Asn 
    1715                 1720                 1725             


Gln Trp  Arg Asp Gln Leu Arg  Pro Ser Gln Leu Leu  His Leu Phe 
    1730                 1735                 1740             


Cys Gln  Gln His Arg Val Lys  Ala Pro Val Tyr Arg  Thr Asp Arg 
    1745                 1750                 1755             


Val Met  Phe Gln Asp Lys Glu  Tyr Ser Ile Glu Glu  Ile Glu Ala 
    1760                 1765                 1770             


Gly Arg  Ile Pro Asn Pro His  Leu Gly Pro Val Glu  Glu Arg Leu 
    1775                 1780                 1785             


Ala Leu  His Val Leu Gln Gln  Gln Gly Leu Val Pro  Glu His Val 
    1790                 1795                 1800             


Glu Ser  Arg Pro Leu Tyr Ser  Pro Leu Gln Pro Asp  Ile Glu Gln 
    1805                 1810                 1815             


Gly Lys  Leu Gln Met Trp Val  Asp Leu Phe Pro Lys  Ala Leu Gly 
    1820                 1825                 1830             


Arg Pro  Gly Pro Pro Phe Asn  Ile Thr Pro Arg Arg  Ala Arg Arg 
    1835                 1840                 1845             


Phe Phe  Leu Arg Cys Ile Ile  Trp Asn Thr Arg Asp  Val Ile Leu 
    1850                 1855                 1860             


Asp Asp  Leu Ser Leu Thr Gly  Glu Lys Met Ser Asp  Ile Tyr Val 
    1865                 1870                 1875             


Lys Gly  Trp Met Ile Gly Phe  Glu Glu His Lys Gln  Lys Thr Asp 
    1880                 1885                 1890             


Val His  Tyr Arg Ser Leu Gly  Gly Glu Gly Asn Phe  Asn Trp Arg 
    1895                 1900                 1905             


Phe Ile  Phe Pro Phe Asp Tyr  Leu Pro Ala Glu Gln  Val Cys Thr 
    1910                 1915                 1920             


Ile Ala  Lys Lys Asp Ala Phe  Trp Arg Leu Asp Lys  Thr Glu Ser 
    1925                 1930                 1935             


Lys Ile  Pro Ala Arg Val Val  Phe Gln Ile Trp Asp  Asn Asp Lys 
    1940                 1945                 1950             


Phe Ser  Phe Asp Asp Phe Leu  Gly Ser Leu Gln Leu  Asp Leu Asn 
    1955                 1960                 1965             


Arg Met  Pro Lys Pro Ala Lys  Thr Ala Lys Lys Cys  Ser Leu Asp 
    1970                 1975                 1980             


Gln Leu  Asp Asp Ala Phe His  Pro Glu Trp Phe Val  Ser Leu Phe 
    1985                 1990                 1995             


Glu Gln  Lys Thr Val Lys Gly  Trp Trp Pro Cys Val  Ala Glu Glu 
    2000                 2005                 2010             


Gly Glu  Lys Lys Ile Leu Ala  Gly Lys Leu Glu Met  Thr Leu Glu 
    2015                 2020                 2025             


Ile Val  Ala Glu Ser Glu His  Glu Glu Arg Pro Ala  Gly Gln Gly 
    2030                 2035                 2040             


Arg Asp  Glu Pro Asn Met Asn  Pro Lys Leu Glu Asp  Pro Arg Arg 
    2045                 2050                 2055             


Pro Asp  Thr Ser Phe Leu Trp  Phe Thr Ser Pro Tyr  Lys Thr Met 
    2060                 2065                 2070             


Lys Phe  Ile Leu Trp Arg Arg  Phe Arg Trp Ala Ile  Ile Leu Phe 
    2075                 2080                 2085             


Ile Ile  Leu Phe Ile Leu Leu  Leu Phe Leu Ala Ile  Phe Ile Tyr 
    2090                 2095                 2100             


Ala Phe  Pro Asn Tyr Ala Ala  Met Lys Leu Val Lys  Pro Phe Ser 
    2105                 2110                 2115             


<210>  1459
<211>  2112
<212>  PRT
<213>  Homo sapiens

<400>  1459

Met Leu Cys Cys Leu Leu Val Arg Ala Ser Asn Leu Pro Ser Ala Lys 
1               5                   10                  15      


Lys Asp Arg Arg Ser Asp Pro Val Ala Ser Leu Thr Phe Arg Gly Val 
            20                  25                  30          


Lys Lys Arg Thr Lys Val Ile Lys Asn Ser Val Asn Pro Val Trp Asn 
        35                  40                  45              


Glu Gly Phe Glu Trp Asp Leu Lys Gly Ile Pro Leu Asp Gln Gly Ser 
    50                  55                  60                  


Glu Leu His Val Val Val Lys Asp His Glu Thr Met Gly Arg Asn Arg 
65                  70                  75                  80  


Phe Leu Gly Glu Ala Lys Val Pro Leu Arg Glu Val Leu Ala Thr Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Phe Asn Ala Pro Leu Leu Asp Thr Lys Lys Gln 
            100                 105                 110         


Pro Thr Gly Ala Ser Leu Val Leu Gln Val Ser Tyr Thr Pro Leu Pro 
        115                 120                 125             


Gly Ala Val Pro Leu Phe Pro Pro Pro Thr Pro Leu Glu Pro Ser Pro 
    130                 135                 140                 


Thr Leu Pro Asp Leu Asp Val Val Ala Gly Gly Gly Gln Ser Arg Ala 
145                 150                 155                 160 


Glu Thr Trp Ser Leu Leu Ser Asp Ser Thr Met Asp Thr Arg Tyr Ser 
                165                 170                 175     


Gly Lys Lys Trp Pro Ala Pro Thr Asp Thr Gly Gly Glu Glu Asp Thr 
            180                 185                 190         


Glu Asp Gln Gly Leu Thr Gly Asp Glu Ala Glu Pro Phe Leu Asp Gln 
        195                 200                 205             


Ser Gly Gly Pro Gly Ala Pro Thr Thr Pro Arg Lys Leu Pro Ser Arg 
    210                 215                 220                 


Pro Pro Pro His Tyr Pro Gly Ile Lys Arg Lys Arg Ser Ala Pro Thr 
225                 230                 235                 240 


Ser Arg Lys Leu Leu Ser Asp Lys Pro Gln Asp Phe Gln Ile Arg Val 
                245                 250                 255     


Gln Val Ile Glu Gly Arg Gln Leu Pro Gly Val Asn Ile Lys Pro Val 
            260                 265                 270         


Val Lys Val Thr Ala Ala Gly Gln Thr Lys Arg Thr Arg Ile His Lys 
        275                 280                 285             


Gly Asn Ser Pro Leu Phe Asn Glu Thr Leu Phe Phe Asn Leu Phe Asp 
    290                 295                 300                 


Ser Pro Gly Glu Leu Phe Asp Glu Pro Ile Phe Ile Thr Val Val Asp 
305                 310                 315                 320 


Ser Arg Ser Leu Arg Thr Asp Ala Leu Leu Gly Glu Phe Arg Met Asp 
                325                 330                 335     


Val Gly Thr Ile Tyr Arg Glu Pro Arg His Ala Tyr Leu Arg Lys Trp 
            340                 345                 350         


Leu Leu Leu Ser Asp Pro Asp Asp Phe Ser Ala Gly Ala Arg Gly Tyr 
        355                 360                 365             


Leu Lys Thr Ser Leu Cys Val Leu Gly Pro Gly Asp Glu Ala Pro Leu 
    370                 375                 380                 


Glu Arg Lys Asp Pro Ser Glu Asp Lys Glu Asp Ile Glu Ser Asn Leu 
385                 390                 395                 400 


Leu Arg Pro Thr Gly Val Ala Leu Arg Gly Ala His Phe Cys Leu Lys 
                405                 410                 415     


Val Phe Arg Ala Glu Asp Leu Pro Gln Met Asp Asp Ala Val Met Asp 
            420                 425                 430         


Asn Val Lys Gln Ile Phe Gly Phe Glu Ser Asn Lys Lys Asn Leu Val 
        435                 440                 445             


Asp Pro Phe Val Glu Val Ser Phe Ala Gly Lys Met Leu Cys Ser Lys 
    450                 455                 460                 


Ile Leu Glu Lys Thr Ala Asn Pro Gln Trp Asn Gln Asn Ile Thr Leu 
465                 470                 475                 480 


Pro Ala Met Phe Pro Ser Met Cys Glu Lys Met Arg Ile Arg Ile Ile 
                485                 490                 495     


Asp Trp Asp Arg Leu Thr His Asn Asp Ile Val Ala Thr Thr Tyr Leu 
            500                 505                 510         


Ser Met Ser Lys Ile Ser Ala Pro Gly Gly Glu Ile Glu Glu Glu Pro 
        515                 520                 525             


Ala Gly Ala Val Lys Pro Ser Lys Ala Ser Asp Leu Asp Asp Tyr Leu 
    530                 535                 540                 


Gly Phe Leu Pro Thr Phe Gly Pro Cys Tyr Ile Asn Leu Tyr Gly Ser 
545                 550                 555                 560 


Pro Arg Glu Phe Thr Gly Phe Pro Asp Pro Tyr Thr Glu Leu Asn Thr 
                565                 570                 575     


Gly Lys Gly Glu Gly Val Ala Tyr Arg Gly Arg Leu Leu Leu Ser Leu 
            580                 585                 590         


Glu Thr Lys Leu Val Glu His Ser Glu Gln Lys Val Glu Asp Leu Pro 
        595                 600                 605             


Ala Asp Asp Ile Leu Arg Val Glu Lys Tyr Leu Arg Arg Arg Lys Tyr 
    610                 615                 620                 


Ser Leu Phe Ala Ala Phe Tyr Ser Ala Thr Met Leu Gln Asp Val Asp 
625                 630                 635                 640 


Asp Ala Ile Gln Phe Glu Val Ser Ile Gly Asn Tyr Gly Asn Lys Phe 
                645                 650                 655     


Asp Met Thr Cys Leu Pro Leu Ala Ser Thr Thr Gln Tyr Ser Arg Ala 
            660                 665                 670         


Val Phe Asp Gly Cys His Tyr Tyr Tyr Leu Pro Trp Gly Asn Val Lys 
        675                 680                 685             


Pro Val Val Val Leu Ser Ser Tyr Trp Glu Asp Ile Ser His Arg Ile 
    690                 695                 700                 


Glu Thr Gln Asn Gln Leu Leu Gly Ile Ala Asp Arg Leu Glu Ala Gly 
705                 710                 715                 720 


Leu Glu Gln Val His Leu Ala Leu Lys Ala Gln Cys Ser Thr Glu Asp 
                725                 730                 735     


Val Asp Ser Leu Val Ala Gln Leu Thr Asp Glu Leu Ile Ala Gly Cys 
            740                 745                 750         


Ser Gln Pro Leu Gly Asp Ile His Glu Thr Pro Ser Ala Thr His Leu 
        755                 760                 765             


Asp Gln Tyr Leu Tyr Gln Leu Arg Thr His His Leu Ser Gln Ile Thr 
    770                 775                 780                 


Glu Ala Ala Leu Ala Leu Lys Leu Gly His Ser Glu Leu Pro Ala Ala 
785                 790                 795                 800 


Leu Glu Gln Ala Glu Asp Trp Leu Leu Arg Leu Arg Ala Leu Ala Glu 
                805                 810                 815     


Glu Pro Gln Asn Ser Leu Pro Asp Ile Val Ile Trp Met Leu Gln Gly 
            820                 825                 830         


Asp Lys Arg Val Ala Tyr Gln Arg Val Pro Ala His Gln Val Leu Phe 
        835                 840                 845             


Ser Arg Arg Gly Ala Asn Tyr Cys Gly Lys Asn Cys Gly Lys Leu Gln 
    850                 855                 860                 


Thr Ile Phe Leu Lys Tyr Pro Met Glu Lys Val Pro Gly Ala Arg Met 
865                 870                 875                 880 


Pro Val Gln Ile Arg Val Lys Leu Trp Phe Gly Leu Ser Val Asp Glu 
                885                 890                 895     


Lys Glu Phe Asn Gln Phe Ala Glu Gly Lys Leu Ser Val Phe Ala Glu 
            900                 905                 910         


Thr Tyr Glu Asn Glu Thr Lys Leu Ala Leu Val Gly Asn Trp Gly Thr 
        915                 920                 925             


Thr Gly Leu Thr Tyr Pro Lys Phe Ser Asp Val Thr Gly Lys Ile Lys 
    930                 935                 940                 


Leu Pro Lys Asp Ser Phe Arg Pro Ser Ala Gly Trp Thr Trp Ala Gly 
945                 950                 955                 960 


Asp Trp Phe Val Cys Pro Glu Lys Thr Leu Leu His Asp Met Asp Ala 
                965                 970                 975     


Gly His Leu Ser Phe Val Glu Glu Val Phe Glu Asn Gln Thr Arg Leu 
            980                 985                 990         


Pro Gly Gly Gln Trp Ile Tyr Met  Ser Asp Asn Tyr Thr  Asp Val Asn 
        995                 1000                 1005             


Gly Glu  Lys Val Leu Pro Lys  Asp Asp Ile Glu Cys  Pro Leu Gly 
    1010                 1015                 1020             


Trp Lys  Trp Glu Asp Glu Glu  Trp Ser Thr Asp Leu  Asn Arg Ala 
    1025                 1030                 1035             


Val Asp  Glu Gln Gly Trp Glu  Tyr Ser Ile Thr Ile  Pro Pro Glu 
    1040                 1045                 1050             


Arg Lys  Pro Lys His Trp Val  Pro Ala Glu Lys Met  Tyr Tyr Thr 
    1055                 1060                 1065             


His Arg  Arg Arg Arg Trp Val  Arg Leu Arg Arg Arg  Asp Leu Ser 
    1070                 1075                 1080             


Gln Met  Glu Ala Leu Lys Arg  His Arg Gln Ala Glu  Ala Glu Gly 
    1085                 1090                 1095             


Glu Gly  Trp Glu Tyr Ala Ser  Leu Phe Gly Trp Lys  Phe His Leu 
    1100                 1105                 1110             


Glu Tyr  Arg Lys Thr Asp Ala  Phe Arg Arg Arg Arg  Trp Arg Arg 
    1115                 1120                 1125             


Arg Met  Glu Pro Leu Glu Lys  Thr Gly Pro Ala Ala  Val Phe Ala 
    1130                 1135                 1140             


Leu Glu  Gly Ala Leu Gly Gly  Val Met Asp Asp Lys  Ser Glu Asp 
    1145                 1150                 1155             


Ser Met  Ser Val Ser Thr Leu  Ser Phe Gly Val Asn  Arg Pro Thr 
    1160                 1165                 1170             


Ile Ser  Cys Ile Phe Asp Tyr  Gly Asn Arg Tyr His  Leu Arg Cys 
    1175                 1180                 1185             


Tyr Met  Tyr Gln Ala Arg Asp  Leu Ala Ala Met Asp  Lys Asp Ser 
    1190                 1195                 1200             


Phe Ser  Asp Pro Tyr Ala Ile  Val Ser Phe Leu His  Gln Ser Gln 
    1205                 1210                 1215             


Lys Thr  Val Val Val Lys Asn  Thr Leu Asn Pro Thr  Trp Asp Gln 
    1220                 1225                 1230             


Thr Leu  Ile Phe Tyr Glu Ile  Glu Ile Phe Gly Glu  Pro Ala Thr 
    1235                 1240                 1245             


Val Ala  Glu Gln Pro Pro Ser  Ile Val Val Glu Leu  Tyr Asp His 
    1250                 1255                 1260             


Asp Thr  Tyr Gly Ala Asp Glu  Phe Met Gly Arg Cys  Ile Cys Gln 
    1265                 1270                 1275             


Pro Ser  Leu Glu Arg Met Pro  Arg Leu Ala Trp Phe  Pro Leu Thr 
    1280                 1285                 1290             


Arg Gly  Ser Gln Pro Ser Gly  Glu Leu Leu Ala Ser  Phe Glu Leu 
    1295                 1300                 1305             


Ile Gln  Arg Glu Lys Pro Ala  Ile His His Ile Pro  Gly Phe Glu 
    1310                 1315                 1320             


Val Gln  Glu Thr Ser Arg Ile  Leu Asp Glu Ser Glu  Asp Thr Asp 
    1325                 1330                 1335             


Leu Pro  Tyr Pro Pro Pro Gln  Arg Glu Ala Asn Ile  Tyr Met Val 
    1340                 1345                 1350             


Pro Gln  Asn Ile Lys Pro Ala  Leu Gln Arg Thr Ala  Ile Glu Ile 
    1355                 1360                 1365             


Leu Ala  Trp Gly Leu Arg Asn  Met Lys Ser Tyr Gln  Leu Ala Asn 
    1370                 1375                 1380             


Ile Ser  Ser Pro Ser Leu Val  Val Glu Cys Gly Gly  Gln Thr Val 
    1385                 1390                 1395             


Gln Ser  Cys Val Ile Arg Asn  Leu Arg Lys Asn Pro  Asn Phe Asp 
    1400                 1405                 1410             


Ile Cys  Thr Leu Phe Met Glu  Val Met Leu Pro Arg  Glu Glu Leu 
    1415                 1420                 1425             


Tyr Cys  Pro Pro Ile Thr Val  Lys Val Ile Asp Asn  Arg Gln Phe 
    1430                 1435                 1440             


Gly Arg  Arg Pro Val Val Gly  Gln Cys Thr Ile Arg  Ser Leu Glu 
    1445                 1450                 1455             


Ser Phe  Leu Cys Asp Pro Tyr  Ser Ala Glu Ser Pro  Ser Pro Gln 
    1460                 1465                 1470             


Gly Gly  Pro Asp Asp Val Ser  Leu Leu Ser Pro Gly  Glu Asp Val 
    1475                 1480                 1485             


Leu Ile  Asp Ile Asp Asp Lys  Glu Pro Leu Ile Pro  Ile Gln Glu 
    1490                 1495                 1500             


Glu Glu  Phe Ile Asp Trp Trp  Ser Lys Phe Phe Ala  Ser Ile Gly 
    1505                 1510                 1515             


Glu Arg  Glu Lys Cys Gly Ser  Tyr Leu Glu Lys Asp  Phe Asp Thr 
    1520                 1525                 1530             


Leu Lys  Val Tyr Asp Thr Gln  Leu Glu Asn Val Glu  Ala Phe Glu 
    1535                 1540                 1545             


Gly Leu  Ser Asp Phe Cys Asn  Thr Phe Lys Leu Tyr  Arg Gly Lys 
    1550                 1555                 1560             


Thr Gln  Glu Glu Thr Glu Asp  Pro Ser Val Ile Gly  Glu Phe Lys 
    1565                 1570                 1575             


Gly Leu  Phe Lys Ile Tyr Pro  Leu Pro Glu Asp Pro  Ala Ile Pro 
    1580                 1585                 1590             


Met Pro  Pro Arg Gln Phe His  Gln Leu Ala Ala Gln  Gly Pro Gln 
    1595                 1600                 1605             


Glu Cys  Leu Val Arg Ile Tyr  Ile Val Arg Ala Phe  Gly Leu Gln 
    1610                 1615                 1620             


Pro Lys  Asp Pro Asn Gly Lys  Cys Asp Pro Tyr Ile  Lys Ile Ser 
    1625                 1630                 1635             


Ile Gly  Lys Lys Ser Val Ser  Asp Gln Asp Asn Tyr  Ile Pro Cys 
    1640                 1645                 1650             


Thr Leu  Glu Pro Val Phe Gly  Lys Met Phe Glu Leu  Thr Cys Thr 
    1655                 1660                 1665             


Leu Pro  Leu Glu Lys Asp Leu  Lys Ile Thr Leu Tyr  Asp Tyr Asp 
    1670                 1675                 1680             


Leu Leu  Ser Lys Asp Glu Lys  Ile Gly Glu Thr Val  Val Asp Leu 
    1685                 1690                 1695             


Glu Asn  Arg Leu Leu Ser Lys  Phe Gly Ala Arg Cys  Gly Leu Pro 
    1700                 1705                 1710             


Gln Thr  Tyr Cys Val Ser Gly  Pro Asn Gln Trp Arg  Asp Gln Leu 
    1715                 1720                 1725             


Arg Pro  Ser Gln Leu Leu His  Leu Phe Cys Gln Gln  His Arg Val 
    1730                 1735                 1740             


Lys Ala  Pro Val Tyr Arg Thr  Asp Arg Val Met Phe  Gln Asp Lys 
    1745                 1750                 1755             


Glu Tyr  Ser Ile Glu Glu Ile  Glu Ala Gly Arg Ile  Pro Asn Pro 
    1760                 1765                 1770             


His Leu  Gly Pro Val Glu Glu  Arg Leu Ala Leu His  Val Leu Gln 
    1775                 1780                 1785             


Gln Gln  Gly Leu Val Pro Glu  His Val Glu Ser Arg  Pro Leu Tyr 
    1790                 1795                 1800             


Ser Pro  Leu Gln Pro Asp Ile  Glu Gln Gly Lys Leu  Gln Met Trp 
    1805                 1810                 1815             


Val Asp  Leu Phe Pro Lys Ala  Leu Gly Arg Pro Gly  Pro Pro Phe 
    1820                 1825                 1830             


Asn Ile  Thr Pro Arg Arg Ala  Arg Arg Phe Phe Leu  Arg Cys Ile 
    1835                 1840                 1845             


Ile Trp  Asn Thr Arg Asp Val  Ile Leu Asp Asp Leu  Ser Leu Thr 
    1850                 1855                 1860             


Gly Glu  Lys Met Ser Asp Ile  Tyr Val Lys Gly Trp  Met Ile Gly 
    1865                 1870                 1875             


Phe Glu  Glu His Lys Gln Lys  Thr Asp Val His Tyr  Arg Ser Leu 
    1880                 1885                 1890             


Gly Gly  Glu Gly Asn Phe Asn  Trp Arg Phe Ile Phe  Pro Phe Asp 
    1895                 1900                 1905             


Tyr Leu  Pro Ala Glu Gln Val  Cys Thr Ile Ala Lys  Lys Asp Ala 
    1910                 1915                 1920             


Phe Trp  Arg Leu Asp Lys Thr  Glu Ser Lys Ile Pro  Ala Arg Val 
    1925                 1930                 1935             


Val Phe  Gln Ile Trp Asp Asn  Asp Lys Phe Ser Phe  Asp Asp Phe 
    1940                 1945                 1950             


Leu Gly  Ser Leu Gln Leu Asp  Leu Asn Arg Met Pro  Lys Pro Ala 
    1955                 1960                 1965             


Lys Thr  Ala Lys Lys Cys Ser  Leu Asp Gln Leu Asp  Asp Ala Phe 
    1970                 1975                 1980             


His Pro  Glu Trp Phe Val Ser  Leu Phe Glu Gln Lys  Thr Val Lys 
    1985                 1990                 1995             


Gly Trp  Trp Pro Cys Val Ala  Glu Glu Gly Glu Lys  Lys Ile Leu 
    2000                 2005                 2010             


Ala Gly  Lys Leu Glu Met Thr  Leu Glu Ile Val Ala  Glu Ser Glu 
    2015                 2020                 2025             


His Glu  Glu Arg Pro Ala Gly  Gln Gly Arg Asp Glu  Pro Asn Met 
    2030                 2035                 2040             


Asn Pro  Lys Leu Glu Asp Pro  Arg Arg Pro Asp Thr  Ser Phe Leu 
    2045                 2050                 2055             


Trp Phe  Thr Ser Pro Tyr Lys  Thr Met Lys Phe Ile  Leu Trp Arg 
    2060                 2065                 2070             


Arg Phe  Arg Trp Ala Ile Ile  Leu Phe Ile Ile Leu  Phe Ile Leu 
    2075                 2080                 2085             


Leu Leu  Phe Leu Ala Ile Phe  Ile Tyr Ala Phe Pro  Asn Tyr Ala 
    2090                 2095                 2100             


Ala Met  Lys Leu Val Lys Pro  Phe Ser 
    2105                 2110         


<210>  1460
<211>  2102
<212>  PRT
<213>  Homo sapiens

<400>  1460

Met Leu Cys Cys Leu Leu Val Arg Ala Ser Asn Leu Pro Ser Ala Lys 
1               5                   10                  15      


Lys Asp Arg Arg Ser Asp Pro Val Ala Ser Leu Thr Phe Arg Gly Val 
            20                  25                  30          


Lys Lys Arg Thr Lys Val Ile Lys Asn Ser Val Asn Pro Val Trp Asn 
        35                  40                  45              


Glu Gly Phe Glu Trp Asp Leu Lys Gly Ile Pro Leu Asp Gln Gly Ser 
    50                  55                  60                  


Glu Leu His Val Val Val Lys Asp His Glu Thr Met Gly Arg Asn Arg 
65                  70                  75                  80  


Phe Leu Gly Glu Ala Lys Val Pro Leu Arg Glu Val Leu Ala Thr Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Phe Asn Ala Pro Leu Leu Asp Thr Lys Lys Gln 
            100                 105                 110         


Pro Thr Gly Ala Ser Leu Val Leu Gln Val Ser Tyr Thr Pro Leu Pro 
        115                 120                 125             


Gly Ala Val Pro Leu Phe Pro Pro Pro Thr Pro Leu Glu Pro Ser Pro 
    130                 135                 140                 


Thr Leu Pro Asp Leu Asp Val Val Ala Asp Thr Gly Gly Glu Glu Asp 
145                 150                 155                 160 


Thr Glu Asp Gln Gly Leu Thr Gly Asp Glu Ala Glu Pro Phe Leu Asp 
                165                 170                 175     


Gln Ser Gly Gly Pro Gly Ala Pro Thr Thr Pro Arg Lys Leu Pro Ser 
            180                 185                 190         


Arg Pro Pro Pro His Tyr Pro Gly Ile Lys Arg Lys Arg Ser Ala Pro 
        195                 200                 205             


Thr Ser Arg Lys Leu Leu Ser Asp Lys Pro Gln Asp Phe Gln Ile Arg 
    210                 215                 220                 


Val Gln Val Ile Glu Gly Arg Gln Leu Pro Gly Val Asn Ile Lys Pro 
225                 230                 235                 240 


Val Val Lys Val Thr Ala Ala Gly Gln Thr Lys Arg Thr Arg Ile His 
                245                 250                 255     


Lys Gly Asn Ser Pro Leu Phe Asn Glu Thr Leu Phe Phe Asn Leu Phe 
            260                 265                 270         


Asp Ser Pro Gly Glu Leu Phe Asp Glu Pro Ile Phe Ile Thr Val Val 
        275                 280                 285             


Asp Ser Arg Ser Leu Arg Thr Asp Ala Leu Leu Gly Glu Phe Arg Met 
    290                 295                 300                 


Asp Val Gly Thr Ile Tyr Arg Glu Pro Arg His Ala Tyr Leu Arg Lys 
305                 310                 315                 320 


Trp Leu Leu Leu Ser Asp Pro Asp Asp Phe Ser Ala Gly Ala Arg Gly 
                325                 330                 335     


Tyr Leu Lys Thr Ser Leu Cys Val Leu Gly Pro Gly Asp Glu Ala Pro 
            340                 345                 350         


Leu Glu Arg Lys Asp Pro Ser Glu Asp Lys Glu Asp Ile Glu Ser Asn 
        355                 360                 365             


Leu Leu Arg Pro Thr Gly Val Ala Leu Arg Gly Ala His Phe Cys Leu 
    370                 375                 380                 


Lys Val Phe Arg Ala Glu Asp Leu Pro Gln Met Asp Asp Ala Val Met 
385                 390                 395                 400 


Asp Asn Val Lys Gln Ile Phe Gly Phe Glu Ser Asn Lys Lys Asn Leu 
                405                 410                 415     


Val Asp Pro Phe Val Glu Val Ser Phe Ala Gly Lys Met Leu Cys Ser 
            420                 425                 430         


Lys Ile Leu Glu Lys Thr Ala Asn Pro Gln Trp Asn Gln Asn Ile Thr 
        435                 440                 445             


Leu Pro Ala Met Phe Pro Ser Met Cys Glu Lys Met Arg Ile Arg Ile 
    450                 455                 460                 


Ile Asp Trp Asp Arg Leu Thr His Asn Asp Ile Val Ala Thr Thr Tyr 
465                 470                 475                 480 


Leu Ser Met Ser Lys Ile Ser Ala Pro Gly Gly Glu Ile Glu Glu Glu 
                485                 490                 495     


Pro Ala Gly Ala Val Lys Pro Ser Lys Ala Ser Asp Leu Asp Asp Tyr 
            500                 505                 510         


Leu Gly Phe Leu Pro Thr Phe Gly Pro Cys Tyr Ile Asn Leu Tyr Gly 
        515                 520                 525             


Ser Pro Arg Glu Phe Thr Gly Phe Pro Asp Pro Tyr Thr Glu Leu Asn 
    530                 535                 540                 


Thr Gly Lys Gly Glu Gly Val Ala Tyr Arg Gly Arg Leu Leu Leu Ser 
545                 550                 555                 560 


Leu Glu Thr Lys Leu Val Glu His Ser Glu Gln Lys Val Glu Asp Leu 
                565                 570                 575     


Pro Ala Asp Asp Ile Leu Arg Val Glu Lys Tyr Leu Arg Arg Arg Lys 
            580                 585                 590         


Tyr Ser Leu Phe Ala Ala Phe Tyr Ser Ala Thr Met Leu Gln Asp Val 
        595                 600                 605             


Asp Asp Ala Ile Gln Phe Glu Val Ser Ile Gly Asn Tyr Gly Asn Lys 
    610                 615                 620                 


Phe Asp Met Thr Cys Leu Pro Leu Ala Ser Thr Thr Gln Tyr Ser Arg 
625                 630                 635                 640 


Ala Val Phe Asp Gly Cys His Tyr Tyr Tyr Leu Pro Trp Gly Asn Val 
                645                 650                 655     


Lys Pro Val Val Val Leu Ser Ser Tyr Trp Glu Asp Ile Ser His Arg 
            660                 665                 670         


Ile Glu Thr Gln Asn Gln Leu Leu Gly Ile Ala Asp Arg Leu Glu Ala 
        675                 680                 685             


Gly Leu Glu Gln Val His Leu Ala Leu Lys Ala Gln Cys Ser Thr Glu 
    690                 695                 700                 


Asp Val Asp Ser Leu Val Ala Gln Leu Thr Asp Glu Leu Ile Ala Gly 
705                 710                 715                 720 


Cys Ser Gln Pro Leu Gly Asp Ile His Glu Thr Pro Ser Ala Thr His 
                725                 730                 735     


Leu Asp Gln Tyr Leu Tyr Gln Leu Arg Thr His His Leu Ser Gln Ile 
            740                 745                 750         


Thr Glu Ala Ala Leu Ala Leu Lys Leu Gly His Ser Glu Leu Pro Ala 
        755                 760                 765             


Ala Leu Glu Gln Ala Glu Asp Trp Leu Leu Arg Leu Arg Ala Leu Ala 
    770                 775                 780                 


Glu Glu Pro Gln Asn Ser Leu Pro Asp Ile Val Ile Trp Met Leu Gln 
785                 790                 795                 800 


Gly Asp Lys Arg Val Ala Tyr Gln Arg Val Pro Ala His Gln Val Leu 
                805                 810                 815     


Phe Ser Arg Arg Gly Ala Asn Tyr Cys Gly Lys Asn Cys Gly Lys Leu 
            820                 825                 830         


Gln Thr Ile Phe Leu Lys Tyr Pro Met Glu Lys Val Pro Gly Ala Arg 
        835                 840                 845             


Met Pro Val Gln Ile Arg Val Lys Leu Trp Phe Gly Leu Ser Val Asp 
    850                 855                 860                 


Glu Lys Glu Phe Asn Gln Phe Ala Glu Gly Lys Leu Ser Val Phe Ala 
865                 870                 875                 880 


Glu Thr Tyr Glu Asn Glu Thr Lys Leu Ala Leu Val Gly Asn Trp Gly 
                885                 890                 895     


Thr Thr Gly Leu Thr Tyr Pro Lys Phe Ser Asp Val Thr Gly Lys Ile 
            900                 905                 910         


Lys Leu Pro Lys Asp Ser Phe Arg Pro Ser Ala Gly Trp Thr Trp Ala 
        915                 920                 925             


Gly Asp Trp Phe Val Cys Pro Glu Lys Thr Leu Leu His Asp Met Asp 
    930                 935                 940                 


Ala Gly His Leu Ser Phe Val Glu Glu Val Phe Glu Asn Gln Thr Arg 
945                 950                 955                 960 


Leu Pro Gly Gly Gln Trp Ile Tyr Met Ser Asp Asn Tyr Thr Asp Val 
                965                 970                 975     


Asn Gly Glu Lys Val Leu Pro Lys Asp Asp Ile Glu Cys Pro Leu Gly 
            980                 985                 990         


Trp Lys Trp Glu Asp Glu Glu Trp  Ser Thr Asp Leu Asn  Arg Ala Val 
        995                 1000                 1005             


Asp Glu  Gln Gly Trp Glu Tyr  Ser Ile Thr Ile Pro  Pro Glu Arg 
    1010                 1015                 1020             


Lys Pro  Lys His Trp Val Pro  Ala Glu Lys Met Tyr  Tyr Thr His 
    1025                 1030                 1035             


Arg Arg  Arg Arg Trp Val Arg  Leu Arg Arg Arg Asp  Leu Ser Gln 
    1040                 1045                 1050             


Met Glu  Ala Leu Lys Arg His  Arg Gln Ala Glu Ala  Glu Gly Glu 
    1055                 1060                 1065             


Gly Trp  Glu Tyr Ala Ser Leu  Phe Gly Trp Lys Phe  His Leu Glu 
    1070                 1075                 1080             


Tyr Arg  Lys Thr Asp Ala Phe  Arg Arg Arg Arg Trp  Arg Arg Arg 
    1085                 1090                 1095             


Met Glu  Pro Leu Glu Lys Thr  Gly Pro Ala Ala Val  Phe Ala Leu 
    1100                 1105                 1110             


Glu Gly  Ala Leu Gly Gly Val  Met Asp Asp Lys Ser  Glu Asp Ser 
    1115                 1120                 1125             


Met Ser  Val Ser Thr Leu Ser  Phe Gly Val Asn Arg  Pro Thr Ile 
    1130                 1135                 1140             


Ser Cys  Ile Phe Asp Tyr Gly  Asn Arg Tyr His Leu  Arg Cys Tyr 
    1145                 1150                 1155             


Met Tyr  Gln Ala Arg Asp Leu  Ala Ala Met Asp Lys  Asp Ser Phe 
    1160                 1165                 1170             


Ser Asp  Pro Tyr Ala Ile Val  Ser Phe Leu His Gln  Ser Gln Lys 
    1175                 1180                 1185             


Thr Val  Val Val Lys Asn Thr  Leu Asn Pro Thr Trp  Asp Gln Thr 
    1190                 1195                 1200             


Leu Ile  Phe Tyr Glu Ile Glu  Ile Phe Gly Glu Pro  Ala Thr Val 
    1205                 1210                 1215             


Ala Glu  Gln Pro Pro Ser Ile  Val Val Glu Leu Tyr  Asp His Asp 
    1220                 1225                 1230             


Thr Tyr  Gly Ala Asp Glu Phe  Met Gly Arg Cys Ile  Cys Gln Pro 
    1235                 1240                 1245             


Ser Leu  Glu Arg Met Pro Arg  Leu Ala Trp Phe Pro  Leu Thr Arg 
    1250                 1255                 1260             


Gly Ser  Gln Pro Ser Gly Glu  Leu Leu Ala Ser Phe  Glu Leu Ile 
    1265                 1270                 1275             


Gln Arg  Glu Lys Pro Ala Ile  His His Ile Pro Gly  Phe Glu Val 
    1280                 1285                 1290             


Gln Glu  Thr Ser Arg Ile Leu  Asp Glu Ser Glu Asp  Thr Asp Leu 
    1295                 1300                 1305             


Pro Tyr  Pro Pro Pro Gln Arg  Glu Ala Asn Ile Tyr  Met Val Pro 
    1310                 1315                 1320             


Gln Asn  Ile Lys Pro Ala Leu  Gln Arg Thr Ala Ile  Glu Ile Leu 
    1325                 1330                 1335             


Ala Trp  Gly Leu Arg Asn Met  Lys Ser Tyr Gln Leu  Ala Asn Ile 
    1340                 1345                 1350             


Ser Ser  Pro Ser Leu Val Val  Glu Cys Gly Gly Gln  Thr Val Gln 
    1355                 1360                 1365             


Ser Cys  Val Ile Arg Asn Leu  Arg Lys Asn Pro Asn  Phe Asp Ile 
    1370                 1375                 1380             


Cys Thr  Leu Phe Met Glu Val  Met Leu Pro Arg Glu  Glu Leu Tyr 
    1385                 1390                 1395             


Cys Pro  Pro Ile Thr Val Lys  Val Ile Asp Asn Arg  Gln Phe Gly 
    1400                 1405                 1410             


Arg Arg  Pro Val Val Gly Gln  Cys Thr Ile Arg Ser  Leu Glu Ser 
    1415                 1420                 1425             


Phe Leu  Cys Asp Pro Tyr Ser  Ala Glu Ser Pro Ser  Pro Gln Gly 
    1430                 1435                 1440             


Gly Pro  Asp Asp Val Ser Leu  Leu Ser Pro Gly Glu  Asp Val Leu 
    1445                 1450                 1455             


Ile Asp  Ile Asp Asp Lys Glu  Pro Leu Ile Pro Ile  Gln Leu Ala 
    1460                 1465                 1470             


Asp Gly  Leu Ser Ser Leu Ala  Pro Thr Asn Thr Ala  Ser Pro Pro 
    1475                 1480                 1485             


Ser Ser  Pro His Glu Glu Glu  Phe Ile Asp Trp Trp  Ser Lys Phe 
    1490                 1495                 1500             


Phe Ala  Ser Ile Gly Glu Arg  Glu Lys Cys Gly Ser  Tyr Leu Glu 
    1505                 1510                 1515             


Lys Asp  Phe Asp Thr Leu Lys  Val Tyr Asp Thr Gln  Leu Glu Asn 
    1520                 1525                 1530             


Val Glu  Ala Phe Glu Gly Leu  Ser Asp Phe Cys Asn  Thr Phe Lys 
    1535                 1540                 1545             


Leu Tyr  Arg Gly Lys Thr Gln  Glu Glu Thr Glu Asp  Pro Ser Val 
    1550                 1555                 1560             


Ile Gly  Glu Phe Lys Gly Leu  Phe Lys Ile Tyr Pro  Leu Pro Glu 
    1565                 1570                 1575             


Asp Pro  Ala Ile Pro Met Pro  Pro Arg Gln Phe His  Gln Leu Ala 
    1580                 1585                 1590             


Ala Gln  Gly Pro Gln Glu Cys  Leu Val Arg Ile Tyr  Ile Val Arg 
    1595                 1600                 1605             


Ala Phe  Gly Leu Gln Pro Lys  Asp Pro Asn Gly Lys  Cys Asp Pro 
    1610                 1615                 1620             


Tyr Ile  Lys Ile Ser Ile Gly  Lys Lys Ser Val Ser  Asp Gln Asp 
    1625                 1630                 1635             


Asn Tyr  Ile Pro Cys Thr Leu  Glu Pro Val Phe Gly  Lys Met Phe 
    1640                 1645                 1650             


Glu Leu  Thr Cys Thr Leu Pro  Leu Glu Lys Asp Leu  Lys Ile Thr 
    1655                 1660                 1665             


Leu Tyr  Asp Tyr Asp Leu Leu  Ser Lys Asp Glu Lys  Ile Gly Glu 
    1670                 1675                 1680             


Thr Val  Val Asp Leu Glu Asn  Arg Leu Leu Ser Lys  Phe Gly Ala 
    1685                 1690                 1695             


Arg Cys  Gly Leu Pro Gln Thr  Tyr Cys Val Ser Gly  Pro Asn Gln 
    1700                 1705                 1710             


Trp Arg  Asp Gln Leu Arg Pro  Ser Gln Leu Leu His  Leu Phe Cys 
    1715                 1720                 1725             


Gln Gln  His Arg Val Lys Ala  Pro Val Tyr Arg Thr  Asp Arg Val 
    1730                 1735                 1740             


Met Phe  Gln Asp Lys Glu Tyr  Ser Ile Glu Glu Ile  Glu Ala Gly 
    1745                 1750                 1755             


Arg Ile  Pro Asn Pro His Leu  Gly Pro Val Glu Glu  Arg Leu Ala 
    1760                 1765                 1770             


Leu His  Val Leu Gln Gln Gln  Gly Leu Val Pro Glu  His Val Glu 
    1775                 1780                 1785             


Ser Arg  Pro Leu Tyr Ser Pro  Leu Gln Pro Asp Ile  Glu Gln Gly 
    1790                 1795                 1800             


Lys Leu  Gln Met Trp Val Asp  Leu Phe Pro Lys Ala  Leu Gly Arg 
    1805                 1810                 1815             


Pro Gly  Pro Pro Phe Asn Ile  Thr Pro Arg Arg Ala  Arg Arg Phe 
    1820                 1825                 1830             


Phe Leu  Arg Cys Ile Ile Trp  Asn Thr Arg Asp Val  Ile Leu Asp 
    1835                 1840                 1845             


Asp Leu  Ser Leu Thr Gly Glu  Lys Met Ser Asp Ile  Tyr Val Lys 
    1850                 1855                 1860             


Gly Trp  Met Ile Gly Phe Glu  Glu His Lys Gln Lys  Thr Asp Val 
    1865                 1870                 1875             


His Tyr  Arg Ser Leu Gly Gly  Glu Gly Asn Phe Asn  Trp Arg Phe 
    1880                 1885                 1890             


Ile Phe  Pro Phe Asp Tyr Leu  Pro Ala Glu Gln Val  Cys Thr Ile 
    1895                 1900                 1905             


Ala Lys  Lys Asp Ala Phe Trp  Arg Leu Asp Lys Thr  Glu Ser Lys 
    1910                 1915                 1920             


Ile Pro  Ala Arg Val Val Phe  Gln Ile Trp Asp Asn  Asp Lys Phe 
    1925                 1930                 1935             


Ser Phe  Asp Asp Phe Leu Gly  Ser Leu Gln Leu Asp  Leu Asn Arg 
    1940                 1945                 1950             


Met Pro  Lys Pro Ala Lys Thr  Ala Lys Lys Cys Ser  Leu Asp Gln 
    1955                 1960                 1965             


Leu Asp  Asp Ala Phe His Pro  Glu Trp Phe Val Ser  Leu Phe Glu 
    1970                 1975                 1980             


Gln Lys  Thr Val Lys Gly Trp  Trp Pro Cys Val Ala  Glu Glu Gly 
    1985                 1990                 1995             


Glu Lys  Lys Ile Leu Ala Gly  Lys Leu Glu Met Thr  Leu Glu Ile 
    2000                 2005                 2010             


Val Ala  Glu Ser Glu His Glu  Glu Arg Pro Ala Gly  Gln Gly Arg 
    2015                 2020                 2025             


Asp Glu  Pro Asn Met Asn Pro  Lys Leu Glu Asp Pro  Arg Arg Pro 
    2030                 2035                 2040             


Asp Thr  Ser Phe Leu Trp Phe  Thr Ser Pro Tyr Lys  Thr Met Lys 
    2045                 2050                 2055             


Phe Ile  Leu Trp Arg Arg Phe  Arg Trp Ala Ile Ile  Leu Phe Ile 
    2060                 2065                 2070             


Ile Leu  Phe Ile Leu Leu Leu  Phe Leu Ala Ile Phe  Ile Tyr Ala 
    2075                 2080                 2085             


Phe Pro  Asn Tyr Ala Ala Met  Lys Leu Val Lys Pro  Phe Ser 
    2090                 2095                 2100         


<210>  1461
<211>  2088
<212>  PRT
<213>  Homo sapiens

<400>  1461

Met Leu Cys Cys Leu Leu Val Arg Ala Ser Asn Leu Pro Ser Ala Lys 
1               5                   10                  15      


Lys Asp Arg Arg Ser Asp Pro Val Ala Ser Leu Thr Phe Arg Gly Val 
            20                  25                  30          


Lys Lys Arg Thr Lys Val Ile Lys Asn Ser Val Asn Pro Val Trp Asn 
        35                  40                  45              


Glu Gly Phe Glu Trp Asp Leu Lys Gly Ile Pro Leu Asp Gln Gly Ser 
    50                  55                  60                  


Glu Leu His Val Val Val Lys Asp His Glu Thr Met Gly Arg Asn Arg 
65                  70                  75                  80  


Phe Leu Gly Glu Ala Lys Val Pro Leu Arg Glu Val Leu Ala Thr Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Phe Asn Ala Pro Leu Leu Asp Thr Lys Lys Gln 
            100                 105                 110         


Pro Thr Gly Ala Ser Leu Val Leu Gln Val Ser Tyr Thr Pro Leu Pro 
        115                 120                 125             


Gly Ala Val Pro Leu Phe Pro Pro Pro Thr Pro Leu Glu Pro Ser Pro 
    130                 135                 140                 


Thr Leu Pro Asp Leu Asp Val Val Ala Asp Thr Gly Gly Glu Glu Asp 
145                 150                 155                 160 


Thr Glu Asp Gln Gly Leu Thr Gly Asp Glu Ala Glu Pro Phe Leu Asp 
                165                 170                 175     


Gln Ser Gly Gly Pro Gly Ala Pro Thr Thr Pro Arg Lys Leu Pro Ser 
            180                 185                 190         


Arg Pro Pro Pro His Tyr Pro Gly Ile Lys Arg Lys Arg Ser Ala Pro 
        195                 200                 205             


Thr Ser Arg Lys Leu Leu Ser Asp Lys Pro Gln Asp Phe Gln Ile Arg 
    210                 215                 220                 


Val Gln Val Ile Glu Gly Arg Gln Leu Pro Gly Val Asn Ile Lys Pro 
225                 230                 235                 240 


Val Val Lys Val Thr Ala Ala Gly Gln Thr Lys Arg Thr Arg Ile His 
                245                 250                 255     


Lys Gly Asn Ser Pro Leu Phe Asn Glu Thr Leu Phe Phe Asn Leu Phe 
            260                 265                 270         


Asp Ser Pro Gly Glu Leu Phe Asp Glu Pro Ile Phe Ile Thr Val Val 
        275                 280                 285             


Asp Ser Arg Ser Leu Arg Thr Asp Ala Leu Leu Gly Glu Phe Arg Met 
    290                 295                 300                 


Asp Val Gly Thr Ile Tyr Arg Glu Pro Arg His Ala Tyr Leu Arg Lys 
305                 310                 315                 320 


Trp Leu Leu Leu Ser Asp Pro Asp Asp Phe Ser Ala Gly Ala Arg Gly 
                325                 330                 335     


Tyr Leu Lys Thr Ser Leu Cys Val Leu Gly Pro Gly Asp Glu Ala Pro 
            340                 345                 350         


Leu Glu Arg Lys Asp Pro Ser Glu Asp Lys Glu Asp Ile Glu Ser Asn 
        355                 360                 365             


Leu Leu Arg Pro Thr Gly Val Ala Leu Arg Gly Ala His Phe Cys Leu 
    370                 375                 380                 


Lys Val Phe Arg Ala Glu Asp Leu Pro Gln Met Asp Asp Ala Val Met 
385                 390                 395                 400 


Asp Asn Val Lys Gln Ile Phe Gly Phe Glu Ser Asn Lys Lys Asn Leu 
                405                 410                 415     


Val Asp Pro Phe Val Glu Val Ser Phe Ala Gly Lys Met Leu Cys Ser 
            420                 425                 430         


Lys Ile Leu Glu Lys Thr Ala Asn Pro Gln Trp Asn Gln Asn Ile Thr 
        435                 440                 445             


Leu Pro Ala Met Phe Pro Ser Met Cys Glu Lys Met Arg Ile Arg Ile 
    450                 455                 460                 


Ile Asp Trp Asp Arg Leu Thr His Asn Asp Ile Val Ala Thr Thr Tyr 
465                 470                 475                 480 


Leu Ser Met Ser Lys Ile Ser Ala Pro Gly Gly Glu Ile Glu Val Asp 
                485                 490                 495     


Asp Tyr Leu Gly Phe Leu Pro Thr Phe Gly Pro Cys Tyr Ile Asn Leu 
            500                 505                 510         


Tyr Gly Ser Pro Arg Glu Phe Thr Gly Phe Pro Asp Pro Tyr Thr Glu 
        515                 520                 525             


Leu Asn Thr Gly Lys Gly Glu Gly Val Ala Tyr Arg Gly Arg Leu Leu 
    530                 535                 540                 


Leu Ser Leu Glu Thr Lys Leu Val Glu His Ser Glu Gln Lys Val Glu 
545                 550                 555                 560 


Asp Leu Pro Ala Asp Asp Ile Leu Arg Val Glu Lys Tyr Leu Arg Arg 
                565                 570                 575     


Arg Lys Tyr Ser Leu Phe Ala Ala Phe Tyr Ser Ala Thr Met Leu Gln 
            580                 585                 590         


Asp Val Asp Asp Ala Ile Gln Phe Glu Val Ser Ile Gly Asn Tyr Gly 
        595                 600                 605             


Asn Lys Phe Asp Met Thr Cys Leu Pro Leu Ala Ser Thr Thr Gln Tyr 
    610                 615                 620                 


Ser Arg Ala Val Phe Asp Gly Cys His Tyr Tyr Tyr Leu Pro Trp Gly 
625                 630                 635                 640 


Asn Val Lys Pro Val Val Val Leu Ser Ser Tyr Trp Glu Asp Ile Ser 
                645                 650                 655     


His Arg Ile Glu Thr Gln Asn Gln Leu Leu Gly Ile Ala Asp Arg Leu 
            660                 665                 670         


Glu Ala Gly Leu Glu Gln Val His Leu Ala Leu Lys Ala Gln Cys Ser 
        675                 680                 685             


Thr Glu Asp Val Asp Ser Leu Val Ala Gln Leu Thr Asp Glu Leu Ile 
    690                 695                 700                 


Ala Gly Cys Ser Gln Pro Leu Gly Asp Ile His Glu Thr Pro Ser Ala 
705                 710                 715                 720 


Thr His Leu Asp Gln Tyr Leu Tyr Gln Leu Arg Thr His His Leu Ser 
                725                 730                 735     


Gln Ile Thr Glu Ala Ala Leu Ala Leu Lys Leu Gly His Ser Glu Leu 
            740                 745                 750         


Pro Ala Ala Leu Glu Gln Ala Glu Asp Trp Leu Leu Arg Leu Arg Ala 
        755                 760                 765             


Leu Ala Glu Glu Pro Gln Asn Ser Leu Pro Asp Ile Val Ile Trp Met 
    770                 775                 780                 


Leu Gln Gly Asp Lys Arg Val Ala Tyr Gln Arg Val Pro Ala His Gln 
785                 790                 795                 800 


Val Leu Phe Ser Arg Arg Gly Ala Asn Tyr Cys Gly Lys Asn Cys Gly 
                805                 810                 815     


Lys Leu Gln Thr Ile Phe Leu Lys Tyr Pro Met Glu Lys Val Pro Gly 
            820                 825                 830         


Ala Arg Met Pro Val Gln Ile Arg Val Lys Leu Trp Phe Gly Leu Ser 
        835                 840                 845             


Val Asp Glu Lys Glu Phe Asn Gln Phe Ala Glu Gly Lys Leu Ser Val 
    850                 855                 860                 


Phe Ala Glu Thr Tyr Glu Asn Glu Thr Lys Leu Ala Leu Val Gly Asn 
865                 870                 875                 880 


Trp Gly Thr Thr Gly Leu Thr Tyr Pro Lys Phe Ser Asp Val Thr Gly 
                885                 890                 895     


Lys Ile Lys Leu Pro Lys Asp Ser Phe Arg Pro Ser Ala Gly Trp Thr 
            900                 905                 910         


Trp Ala Gly Asp Trp Phe Val Cys Pro Glu Lys Thr Leu Leu His Asp 
        915                 920                 925             


Met Asp Ala Gly His Leu Ser Phe Val Glu Glu Val Phe Glu Asn Gln 
    930                 935                 940                 


Thr Arg Leu Pro Gly Gly Gln Trp Ile Tyr Met Ser Asp Asn Tyr Thr 
945                 950                 955                 960 


Asp Val Asn Gly Glu Lys Val Leu Pro Lys Asp Asp Ile Glu Cys Pro 
                965                 970                 975     


Leu Gly Trp Lys Trp Glu Asp Glu Glu Trp Ser Thr Asp Leu Asn Arg 
            980                 985                 990         


Ala Val Asp Glu Gln Gly Trp Glu  Tyr Ser Ile Thr Ile  Pro Pro Glu 
        995                 1000                 1005             


Arg Lys  Pro Lys His Trp Val  Pro Ala Glu Lys Met  Tyr Tyr Thr 
    1010                 1015                 1020             


His Arg  Arg Arg Arg Trp Val  Arg Leu Arg Arg Arg  Asp Leu Ser 
    1025                 1030                 1035             


Gln Met  Glu Ala Leu Lys Arg  His Arg Gln Ala Glu  Ala Glu Gly 
    1040                 1045                 1050             


Glu Gly  Trp Glu Tyr Ala Ser  Leu Phe Gly Trp Lys  Phe His Leu 
    1055                 1060                 1065             


Glu Tyr  Arg Lys Thr Asp Ala  Phe Arg Arg Arg Arg  Trp Arg Arg 
    1070                 1075                 1080             


Arg Met  Glu Pro Leu Glu Lys  Thr Gly Pro Ala Ala  Val Phe Ala 
    1085                 1090                 1095             


Leu Glu  Gly Ala Leu Gly Gly  Val Met Asp Asp Lys  Ser Glu Asp 
    1100                 1105                 1110             


Ser Met  Ser Val Ser Thr Leu  Ser Phe Gly Val Asn  Arg Pro Thr 
    1115                 1120                 1125             


Ile Ser  Cys Ile Phe Asp Tyr  Gly Asn Arg Tyr His  Leu Arg Cys 
    1130                 1135                 1140             


Tyr Met  Tyr Gln Ala Arg Asp  Leu Ala Ala Met Asp  Lys Asp Ser 
    1145                 1150                 1155             


Phe Ser  Asp Pro Tyr Ala Ile  Val Ser Phe Leu His  Gln Ser Gln 
    1160                 1165                 1170             


Lys Thr  Val Val Val Lys Asn  Thr Leu Asn Pro Thr  Trp Asp Gln 
    1175                 1180                 1185             


Thr Leu  Ile Phe Tyr Glu Ile  Glu Ile Phe Gly Glu  Pro Ala Thr 
    1190                 1195                 1200             


Val Ala  Glu Gln Pro Pro Ser  Ile Val Val Glu Leu  Tyr Asp His 
    1205                 1210                 1215             


Asp Thr  Tyr Gly Ala Asp Glu  Phe Met Gly Arg Cys  Ile Cys Gln 
    1220                 1225                 1230             


Pro Ser  Leu Glu Arg Met Pro  Arg Leu Ala Trp Phe  Pro Leu Thr 
    1235                 1240                 1245             


Arg Gly  Ser Gln Pro Ser Gly  Glu Leu Leu Ala Ser  Phe Glu Leu 
    1250                 1255                 1260             


Ile Gln  Arg Glu Lys Pro Ala  Ile His His Ile Pro  Gly Phe Glu 
    1265                 1270                 1275             


Val Gln  Glu Thr Ser Arg Ile  Leu Asp Glu Ser Glu  Asp Thr Asp 
    1280                 1285                 1290             


Leu Pro  Tyr Pro Pro Pro Gln  Arg Glu Ala Asn Ile  Tyr Met Val 
    1295                 1300                 1305             


Pro Gln  Asn Ile Lys Pro Ala  Leu Gln Arg Thr Ala  Ile Glu Ile 
    1310                 1315                 1320             


Leu Ala  Trp Gly Leu Arg Asn  Met Lys Ser Tyr Gln  Leu Ala Asn 
    1325                 1330                 1335             


Ile Ser  Ser Pro Ser Leu Val  Val Glu Cys Gly Gly  Gln Thr Val 
    1340                 1345                 1350             


Gln Ser  Cys Val Ile Arg Asn  Leu Arg Lys Asn Pro  Asn Phe Asp 
    1355                 1360                 1365             


Ile Cys  Thr Leu Phe Met Glu  Val Met Leu Pro Arg  Glu Glu Leu 
    1370                 1375                 1380             


Tyr Cys  Pro Pro Ile Thr Val  Lys Val Ile Asp Asn  Arg Gln Phe 
    1385                 1390                 1395             


Gly Arg  Arg Pro Val Val Gly  Gln Cys Thr Ile Arg  Ser Leu Glu 
    1400                 1405                 1410             


Ser Phe  Leu Cys Asp Pro Tyr  Ser Ala Glu Ser Pro  Ser Pro Gln 
    1415                 1420                 1425             


Gly Gly  Pro Asp Asp Val Ser  Leu Leu Ser Pro Gly  Glu Asp Val 
    1430                 1435                 1440             


Leu Ile  Asp Ile Asp Asp Lys  Glu Pro Leu Ile Pro  Ile Gln Leu 
    1445                 1450                 1455             


Ala Asp  Gly Leu Ser Ser Leu  Ala Pro Thr Asn Thr  Ala Ser Pro 
    1460                 1465                 1470             


Pro Ser  Ser Pro His Glu Glu  Glu Phe Ile Asp Trp  Trp Ser Lys 
    1475                 1480                 1485             


Phe Phe  Ala Ser Ile Gly Glu  Arg Glu Lys Cys Gly  Ser Tyr Leu 
    1490                 1495                 1500             


Glu Lys  Asp Phe Asp Thr Leu  Lys Val Tyr Asp Thr  Gln Leu Glu 
    1505                 1510                 1515             


Asn Val  Glu Ala Phe Glu Gly  Leu Ser Asp Phe Cys  Asn Thr Phe 
    1520                 1525                 1530             


Lys Leu  Tyr Arg Gly Lys Thr  Gln Glu Glu Thr Glu  Asp Pro Ser 
    1535                 1540                 1545             


Val Ile  Gly Glu Phe Lys Gly  Leu Phe Lys Ile Tyr  Pro Leu Pro 
    1550                 1555                 1560             


Glu Asp  Pro Ala Ile Pro Met  Pro Pro Arg Gln Phe  His Gln Leu 
    1565                 1570                 1575             


Ala Ala  Gln Gly Pro Gln Glu  Cys Leu Val Arg Ile  Tyr Ile Val 
    1580                 1585                 1590             


Arg Ala  Phe Gly Leu Gln Pro  Lys Asp Pro Asn Gly  Lys Cys Asp 
    1595                 1600                 1605             


Pro Tyr  Ile Lys Ile Ser Ile  Gly Lys Lys Ser Val  Ser Asp Gln 
    1610                 1615                 1620             


Asp Asn  Tyr Ile Pro Cys Thr  Leu Glu Pro Val Phe  Gly Lys Met 
    1625                 1630                 1635             


Phe Glu  Leu Thr Cys Thr Leu  Pro Leu Glu Lys Asp  Leu Lys Ile 
    1640                 1645                 1650             


Thr Leu  Tyr Asp Tyr Asp Leu  Leu Ser Lys Asp Glu  Lys Ile Gly 
    1655                 1660                 1665             


Glu Thr  Val Val Asp Leu Glu  Asn Arg Leu Leu Ser  Lys Phe Gly 
    1670                 1675                 1680             


Ala Arg  Cys Gly Leu Pro Gln  Thr Tyr Cys Val Ser  Gly Pro Asn 
    1685                 1690                 1695             


Gln Trp  Arg Asp Gln Leu Arg  Pro Ser Gln Leu Leu  His Leu Phe 
    1700                 1705                 1710             


Cys Gln  Gln His Arg Val Lys  Ala Pro Val Tyr Arg  Thr Asp Arg 
    1715                 1720                 1725             


Val Met  Phe Gln Asp Lys Glu  Tyr Ser Ile Glu Glu  Ile Glu Ala 
    1730                 1735                 1740             


Gly Arg  Ile Pro Asn Pro His  Leu Gly Pro Val Glu  Glu Arg Leu 
    1745                 1750                 1755             


Ala Leu  His Val Leu Gln Gln  Gln Gly Leu Val Pro  Glu His Val 
    1760                 1765                 1770             


Glu Ser  Arg Pro Leu Tyr Ser  Pro Leu Gln Pro Asp  Ile Glu Gln 
    1775                 1780                 1785             


Gly Lys  Leu Gln Met Trp Val  Asp Leu Phe Pro Lys  Ala Leu Gly 
    1790                 1795                 1800             


Arg Pro  Gly Pro Pro Phe Asn  Ile Thr Pro Arg Arg  Ala Arg Arg 
    1805                 1810                 1815             


Phe Phe  Leu Arg Cys Ile Ile  Trp Asn Thr Arg Asp  Val Ile Leu 
    1820                 1825                 1830             


Asp Asp  Leu Ser Leu Thr Gly  Glu Lys Met Ser Asp  Ile Tyr Val 
    1835                 1840                 1845             


Lys Gly  Trp Met Ile Gly Phe  Glu Glu His Lys Gln  Lys Thr Asp 
    1850                 1855                 1860             


Val His  Tyr Arg Ser Leu Gly  Gly Glu Gly Asn Phe  Asn Trp Arg 
    1865                 1870                 1875             


Phe Ile  Phe Pro Phe Asp Tyr  Leu Pro Ala Glu Gln  Val Cys Thr 
    1880                 1885                 1890             


Ile Ala  Lys Lys Asp Ala Phe  Trp Arg Leu Asp Lys  Thr Glu Ser 
    1895                 1900                 1905             


Lys Ile  Pro Ala Arg Val Val  Phe Gln Ile Trp Asp  Asn Asp Lys 
    1910                 1915                 1920             


Phe Ser  Phe Asp Asp Phe Leu  Gly Ser Leu Gln Leu  Asp Leu Asn 
    1925                 1930                 1935             


Arg Met  Pro Lys Pro Ala Lys  Thr Ala Lys Lys Cys  Ser Leu Asp 
    1940                 1945                 1950             


Gln Leu  Asp Asp Ala Phe His  Pro Glu Trp Phe Val  Ser Leu Phe 
    1955                 1960                 1965             


Glu Gln  Lys Thr Val Lys Gly  Trp Trp Pro Cys Val  Ala Glu Glu 
    1970                 1975                 1980             


Gly Glu  Lys Lys Ile Leu Ala  Gly Lys Leu Glu Met  Thr Leu Glu 
    1985                 1990                 1995             


Ile Val  Ala Glu Ser Glu His  Glu Glu Arg Pro Ala  Gly Gln Gly 
    2000                 2005                 2010             


Arg Asp  Glu Pro Asn Met Asn  Pro Lys Leu Glu Asp  Pro Arg Arg 
    2015                 2020                 2025             


Pro Asp  Thr Ser Phe Leu Trp  Phe Thr Ser Pro Tyr  Lys Thr Met 
    2030                 2035                 2040             


Lys Phe  Ile Leu Trp Arg Arg  Phe Arg Trp Ala Ile  Ile Leu Phe 
    2045                 2050                 2055             


Ile Ile  Leu Phe Ile Leu Leu  Leu Phe Leu Ala Ile  Phe Ile Tyr 
    2060                 2065                 2070             


Ala Phe  Pro Asn Tyr Ala Ala  Met Lys Leu Val Lys  Pro Phe Ser 
    2075                 2080                 2085             


<210>  1462
<211>  2098
<212>  PRT
<213>  Homo sapiens

<400>  1462

Met Leu Cys Cys Leu Leu Val Arg Ala Ser Asn Leu Pro Ser Ala Lys 
1               5                   10                  15      


Lys Asp Arg Arg Ser Asp Pro Val Ala Ser Leu Thr Phe Arg Gly Val 
            20                  25                  30          


Lys Lys Arg Thr Lys Val Ile Lys Asn Ser Val Asn Pro Val Trp Asn 
        35                  40                  45              


Glu Gly Phe Glu Trp Asp Leu Lys Gly Ile Pro Leu Asp Gln Gly Ser 
    50                  55                  60                  


Glu Leu His Val Val Val Lys Asp His Glu Thr Met Gly Arg Asn Arg 
65                  70                  75                  80  


Phe Leu Gly Glu Ala Lys Val Pro Leu Arg Glu Val Leu Ala Thr Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Phe Asn Ala Pro Leu Leu Asp Thr Lys Lys Gln 
            100                 105                 110         


Pro Thr Gly Ala Ser Leu Val Leu Gln Val Ser Tyr Thr Pro Leu Pro 
        115                 120                 125             


Gly Ala Val Pro Leu Phe Pro Pro Pro Thr Pro Leu Glu Pro Ser Pro 
    130                 135                 140                 


Thr Leu Pro Asp Leu Asp Val Val Ala Gly Gly Gly Gln Ser Arg Ala 
145                 150                 155                 160 


Glu Thr Trp Ser Leu Leu Ser Asp Ser Thr Met Asp Thr Arg Tyr Ser 
                165                 170                 175     


Gly Lys Lys Trp Pro Ala Pro Thr Asp Thr Gly Gly Glu Glu Asp Thr 
            180                 185                 190         


Glu Asp Gln Gly Leu Thr Gly Asp Glu Ala Glu Pro Phe Leu Asp Gln 
        195                 200                 205             


Ser Gly Gly Pro Gly Ala Pro Thr Thr Pro Arg Lys Leu Pro Ser Arg 
    210                 215                 220                 


Pro Pro Pro His Tyr Pro Gly Ile Lys Arg Lys Arg Ser Ala Pro Thr 
225                 230                 235                 240 


Ser Arg Lys Leu Leu Ser Asp Lys Pro Gln Asp Phe Gln Ile Arg Val 
                245                 250                 255     


Gln Val Ile Glu Gly Arg Gln Leu Pro Gly Val Asn Ile Lys Pro Val 
            260                 265                 270         


Val Lys Val Thr Ala Ala Gly Gln Thr Lys Arg Thr Arg Ile His Lys 
        275                 280                 285             


Gly Asn Ser Pro Leu Phe Asn Glu Thr Leu Phe Phe Asn Leu Phe Asp 
    290                 295                 300                 


Ser Pro Gly Glu Leu Phe Asp Glu Pro Ile Phe Ile Thr Val Val Asp 
305                 310                 315                 320 


Ser Arg Ser Leu Arg Thr Asp Ala Leu Leu Gly Glu Phe Arg Met Asp 
                325                 330                 335     


Val Gly Thr Ile Tyr Arg Glu Pro Arg His Ala Tyr Leu Arg Lys Trp 
            340                 345                 350         


Leu Leu Leu Ser Asp Pro Asp Asp Phe Ser Ala Gly Ala Arg Gly Tyr 
        355                 360                 365             


Leu Lys Thr Ser Leu Cys Val Leu Gly Pro Gly Asp Glu Ala Pro Leu 
    370                 375                 380                 


Glu Arg Lys Asp Pro Ser Glu Asp Lys Glu Asp Ile Glu Ser Asn Leu 
385                 390                 395                 400 


Leu Arg Pro Thr Gly Val Ala Leu Arg Gly Ala His Phe Cys Leu Lys 
                405                 410                 415     


Val Phe Arg Ala Glu Asp Leu Pro Gln Met Asp Asp Ala Val Met Asp 
            420                 425                 430         


Asn Val Lys Gln Ile Phe Gly Phe Glu Ser Asn Lys Lys Asn Leu Val 
        435                 440                 445             


Asp Pro Phe Val Glu Val Ser Phe Ala Gly Lys Met Leu Cys Ser Lys 
    450                 455                 460                 


Ile Leu Glu Lys Thr Ala Asn Pro Gln Trp Asn Gln Asn Ile Thr Leu 
465                 470                 475                 480 


Pro Ala Met Phe Pro Ser Met Cys Glu Lys Met Arg Ile Arg Ile Ile 
                485                 490                 495     


Asp Trp Asp Arg Leu Thr His Asn Asp Ile Val Ala Thr Thr Tyr Leu 
            500                 505                 510         


Ser Met Ser Lys Ile Ser Ala Pro Gly Gly Glu Ile Glu Val Asp Asp 
        515                 520                 525             


Tyr Leu Gly Phe Leu Pro Thr Phe Gly Pro Cys Tyr Ile Asn Leu Tyr 
    530                 535                 540                 


Gly Ser Pro Arg Glu Phe Thr Gly Phe Pro Asp Pro Tyr Thr Glu Leu 
545                 550                 555                 560 


Asn Thr Gly Lys Gly Glu Gly Val Ala Tyr Arg Gly Arg Leu Leu Leu 
                565                 570                 575     


Ser Leu Glu Thr Lys Leu Val Glu His Ser Glu Gln Lys Val Glu Asp 
            580                 585                 590         


Leu Pro Ala Asp Asp Ile Leu Arg Val Glu Lys Tyr Leu Arg Arg Arg 
        595                 600                 605             


Lys Tyr Ser Leu Phe Ala Ala Phe Tyr Ser Ala Thr Met Leu Gln Asp 
    610                 615                 620                 


Val Asp Asp Ala Ile Gln Phe Glu Val Ser Ile Gly Asn Tyr Gly Asn 
625                 630                 635                 640 


Lys Phe Asp Met Thr Cys Leu Pro Leu Ala Ser Thr Thr Gln Tyr Ser 
                645                 650                 655     


Arg Ala Val Phe Asp Gly Cys His Tyr Tyr Tyr Leu Pro Trp Gly Asn 
            660                 665                 670         


Val Lys Pro Val Val Val Leu Ser Ser Tyr Trp Glu Asp Ile Ser His 
        675                 680                 685             


Arg Ile Glu Thr Gln Asn Gln Leu Leu Gly Ile Ala Asp Arg Leu Glu 
    690                 695                 700                 


Ala Gly Leu Glu Gln Val His Leu Ala Leu Lys Ala Gln Cys Ser Thr 
705                 710                 715                 720 


Glu Asp Val Asp Ser Leu Val Ala Gln Leu Thr Asp Glu Leu Ile Ala 
                725                 730                 735     


Gly Cys Ser Gln Pro Leu Gly Asp Ile His Glu Thr Pro Ser Ala Thr 
            740                 745                 750         


His Leu Asp Gln Tyr Leu Tyr Gln Leu Arg Thr His His Leu Ser Gln 
        755                 760                 765             


Ile Thr Glu Ala Ala Leu Ala Leu Lys Leu Gly His Ser Glu Leu Pro 
    770                 775                 780                 


Ala Ala Leu Glu Gln Ala Glu Asp Trp Leu Leu Arg Leu Arg Ala Leu 
785                 790                 795                 800 


Ala Glu Glu Pro Gln Asn Ser Leu Pro Asp Ile Val Ile Trp Met Leu 
                805                 810                 815     


Gln Gly Asp Lys Arg Val Ala Tyr Gln Arg Val Pro Ala His Gln Val 
            820                 825                 830         


Leu Phe Ser Arg Arg Gly Ala Asn Tyr Cys Gly Lys Asn Cys Gly Lys 
        835                 840                 845             


Leu Gln Thr Ile Phe Leu Lys Tyr Pro Met Glu Lys Val Pro Gly Ala 
    850                 855                 860                 


Arg Met Pro Val Gln Ile Arg Val Lys Leu Trp Phe Gly Leu Ser Val 
865                 870                 875                 880 


Asp Glu Lys Glu Phe Asn Gln Phe Ala Glu Gly Lys Leu Ser Val Phe 
                885                 890                 895     


Ala Glu Thr Tyr Glu Asn Glu Thr Lys Leu Ala Leu Val Gly Asn Trp 
            900                 905                 910         


Gly Thr Thr Gly Leu Thr Tyr Pro Lys Phe Ser Asp Val Thr Gly Lys 
        915                 920                 925             


Ile Lys Leu Pro Lys Asp Ser Phe Arg Pro Ser Ala Gly Trp Thr Trp 
    930                 935                 940                 


Ala Gly Asp Trp Phe Val Cys Pro Glu Lys Thr Leu Leu His Asp Met 
945                 950                 955                 960 


Asp Ala Gly His Leu Ser Phe Val Glu Glu Val Phe Glu Asn Gln Thr 
                965                 970                 975     


Arg Leu Pro Gly Gly Gln Trp Ile Tyr Met Ser Asp Asn Tyr Thr Asp 
            980                 985                 990         


Val Asn Gly Glu Lys Val Leu Pro  Lys Asp Asp Ile Glu  Cys Pro Leu 
        995                 1000                 1005             


Gly Trp  Lys Trp Glu Asp Glu  Glu Trp Ser Thr Asp  Leu Asn Arg 
    1010                 1015                 1020             


Ala Val  Asp Glu Gln Gly Trp  Glu Tyr Ser Ile Thr  Ile Pro Pro 
    1025                 1030                 1035             


Glu Arg  Lys Pro Lys His Trp  Val Pro Ala Glu Lys  Met Tyr Tyr 
    1040                 1045                 1050             


Thr His  Arg Arg Arg Arg Trp  Val Arg Leu Arg Arg  Arg Asp Leu 
    1055                 1060                 1065             


Ser Gln  Met Glu Ala Leu Lys  Arg His Arg Gln Ala  Glu Ala Glu 
    1070                 1075                 1080             


Gly Glu  Gly Trp Glu Tyr Ala  Ser Leu Phe Gly Trp  Lys Phe His 
    1085                 1090                 1095             


Leu Glu  Tyr Arg Lys Thr Asp  Ala Phe Arg Arg Arg  Arg Trp Arg 
    1100                 1105                 1110             


Arg Arg  Met Glu Pro Leu Glu  Lys Thr Gly Pro Ala  Ala Val Phe 
    1115                 1120                 1125             


Ala Leu  Glu Gly Ala Leu Gly  Gly Val Met Asp Asp  Lys Ser Glu 
    1130                 1135                 1140             


Asp Ser  Met Ser Val Ser Thr  Leu Ser Phe Gly Val  Asn Arg Pro 
    1145                 1150                 1155             


Thr Ile  Ser Cys Ile Phe Asp  Tyr Gly Asn Arg Tyr  His Leu Arg 
    1160                 1165                 1170             


Cys Tyr  Met Tyr Gln Ala Arg  Asp Leu Ala Ala Met  Asp Lys Asp 
    1175                 1180                 1185             


Ser Phe  Ser Asp Pro Tyr Ala  Ile Val Ser Phe Leu  His Gln Ser 
    1190                 1195                 1200             


Gln Lys  Thr Val Val Val Lys  Asn Thr Leu Asn Pro  Thr Trp Asp 
    1205                 1210                 1215             


Gln Thr  Leu Ile Phe Tyr Glu  Ile Glu Ile Phe Gly  Glu Pro Ala 
    1220                 1225                 1230             


Thr Val  Ala Glu Gln Pro Pro  Ser Ile Val Val Glu  Leu Tyr Asp 
    1235                 1240                 1245             


His Asp  Thr Tyr Gly Ala Asp  Glu Phe Met Gly Arg  Cys Ile Cys 
    1250                 1255                 1260             


Gln Pro  Ser Leu Glu Arg Met  Pro Arg Leu Ala Trp  Phe Pro Leu 
    1265                 1270                 1275             


Thr Arg  Gly Ser Gln Pro Ser  Gly Glu Leu Leu Ala  Ser Phe Glu 
    1280                 1285                 1290             


Leu Ile  Gln Arg Glu Lys Pro  Ala Ile His His Ile  Pro Gly Phe 
    1295                 1300                 1305             


Glu Val  Gln Glu Thr Ser Arg  Ile Leu Asp Glu Ser  Glu Asp Thr 
    1310                 1315                 1320             


Asp Leu  Pro Tyr Pro Pro Pro  Gln Arg Glu Ala Asn  Ile Tyr Met 
    1325                 1330                 1335             


Val Pro  Gln Asn Ile Lys Pro  Ala Leu Gln Arg Thr  Ala Ile Glu 
    1340                 1345                 1350             


Ile Leu  Ala Trp Gly Leu Arg  Asn Met Lys Ser Tyr  Gln Leu Ala 
    1355                 1360                 1365             


Asn Ile  Ser Ser Pro Ser Leu  Val Val Glu Cys Gly  Gly Gln Thr 
    1370                 1375                 1380             


Val Gln  Ser Cys Val Ile Arg  Asn Leu Arg Lys Asn  Pro Asn Phe 
    1385                 1390                 1395             


Asp Ile  Cys Thr Leu Phe Met  Glu Val Met Leu Pro  Arg Glu Glu 
    1400                 1405                 1410             


Leu Tyr  Cys Pro Pro Ile Thr  Val Lys Val Ile Asp  Asn Arg Gln 
    1415                 1420                 1425             


Phe Gly  Arg Arg Pro Val Val  Gly Gln Cys Thr Ile  Arg Ser Leu 
    1430                 1435                 1440             


Glu Ser  Phe Leu Cys Asp Pro  Tyr Ser Ala Glu Ser  Pro Ser Pro 
    1445                 1450                 1455             


Gln Gly  Gly Pro Asp Asp Val  Ser Leu Leu Ser Pro  Gly Glu Asp 
    1460                 1465                 1470             


Val Leu  Ile Asp Ile Asp Asp  Lys Glu Pro Leu Ile  Pro Ile Gln 
    1475                 1480                 1485             


Glu Glu  Glu Phe Ile Asp Trp  Trp Ser Lys Phe Phe  Ala Ser Ile 
    1490                 1495                 1500             


Gly Glu  Arg Glu Lys Cys Gly  Ser Tyr Leu Glu Lys  Asp Phe Asp 
    1505                 1510                 1515             


Thr Leu  Lys Val Tyr Asp Thr  Gln Leu Glu Asn Val  Glu Ala Phe 
    1520                 1525                 1530             


Glu Gly  Leu Ser Asp Phe Cys  Asn Thr Phe Lys Leu  Tyr Arg Gly 
    1535                 1540                 1545             


Lys Thr  Gln Glu Glu Thr Glu  Asp Pro Ser Val Ile  Gly Glu Phe 
    1550                 1555                 1560             


Lys Gly  Leu Phe Lys Ile Tyr  Pro Leu Pro Glu Asp  Pro Ala Ile 
    1565                 1570                 1575             


Pro Met  Pro Pro Arg Gln Phe  His Gln Leu Ala Ala  Gln Gly Pro 
    1580                 1585                 1590             


Gln Glu  Cys Leu Val Arg Ile  Tyr Ile Val Arg Ala  Phe Gly Leu 
    1595                 1600                 1605             


Gln Pro  Lys Asp Pro Asn Gly  Lys Cys Asp Pro Tyr  Ile Lys Ile 
    1610                 1615                 1620             


Ser Ile  Gly Lys Lys Ser Val  Ser Asp Gln Asp Asn  Tyr Ile Pro 
    1625                 1630                 1635             


Cys Thr  Leu Glu Pro Val Phe  Gly Lys Met Phe Glu  Leu Thr Cys 
    1640                 1645                 1650             


Thr Leu  Pro Leu Glu Lys Asp  Leu Lys Ile Thr Leu  Tyr Asp Tyr 
    1655                 1660                 1665             


Asp Leu  Leu Ser Lys Asp Glu  Lys Ile Gly Glu Thr  Val Val Asp 
    1670                 1675                 1680             


Leu Glu  Asn Arg Leu Leu Ser  Lys Phe Gly Ala Arg  Cys Gly Leu 
    1685                 1690                 1695             


Pro Gln  Thr Tyr Cys Val Ser  Gly Pro Asn Gln Trp  Arg Asp Gln 
    1700                 1705                 1710             


Leu Arg  Pro Ser Gln Leu Leu  His Leu Phe Cys Gln  Gln His Arg 
    1715                 1720                 1725             


Val Lys  Ala Pro Val Tyr Arg  Thr Asp Arg Val Met  Phe Gln Asp 
    1730                 1735                 1740             


Lys Glu  Tyr Ser Ile Glu Glu  Ile Glu Ala Gly Arg  Ile Pro Asn 
    1745                 1750                 1755             


Pro His  Leu Gly Pro Val Glu  Glu Arg Leu Ala Leu  His Val Leu 
    1760                 1765                 1770             


Gln Gln  Gln Gly Leu Val Pro  Glu His Val Glu Ser  Arg Pro Leu 
    1775                 1780                 1785             


Tyr Ser  Pro Leu Gln Pro Asp  Ile Glu Gln Gly Lys  Leu Gln Met 
    1790                 1795                 1800             


Trp Val  Asp Leu Phe Pro Lys  Ala Leu Gly Arg Pro  Gly Pro Pro 
    1805                 1810                 1815             


Phe Asn  Ile Thr Pro Arg Arg  Ala Arg Arg Phe Phe  Leu Arg Cys 
    1820                 1825                 1830             


Ile Ile  Trp Asn Thr Arg Asp  Val Ile Leu Asp Asp  Leu Ser Leu 
    1835                 1840                 1845             


Thr Gly  Glu Lys Met Ser Asp  Ile Tyr Val Lys Gly  Trp Met Ile 
    1850                 1855                 1860             


Gly Phe  Glu Glu His Lys Gln  Lys Thr Asp Val His  Tyr Arg Ser 
    1865                 1870                 1875             


Leu Gly  Gly Glu Gly Asn Phe  Asn Trp Arg Phe Ile  Phe Pro Phe 
    1880                 1885                 1890             


Asp Tyr  Leu Pro Ala Glu Gln  Val Cys Thr Ile Ala  Lys Lys Asp 
    1895                 1900                 1905             


Ala Phe  Trp Arg Leu Asp Lys  Thr Glu Ser Lys Ile  Pro Ala Arg 
    1910                 1915                 1920             


Val Val  Phe Gln Ile Trp Asp  Asn Asp Lys Phe Ser  Phe Asp Asp 
    1925                 1930                 1935             


Phe Leu  Gly Ser Leu Gln Leu  Asp Leu Asn Arg Met  Pro Lys Pro 
    1940                 1945                 1950             


Ala Lys  Thr Ala Lys Lys Cys  Ser Leu Asp Gln Leu  Asp Asp Ala 
    1955                 1960                 1965             


Phe His  Pro Glu Trp Phe Val  Ser Leu Phe Glu Gln  Lys Thr Val 
    1970                 1975                 1980             


Lys Gly  Trp Trp Pro Cys Val  Ala Glu Glu Gly Glu  Lys Lys Ile 
    1985                 1990                 1995             


Leu Ala  Gly Lys Leu Glu Met  Thr Leu Glu Ile Val  Ala Glu Ser 
    2000                 2005                 2010             


Glu His  Glu Glu Arg Pro Ala  Gly Gln Gly Arg Asp  Glu Pro Asn 
    2015                 2020                 2025             


Met Asn  Pro Lys Leu Glu Asp  Pro Arg Arg Pro Asp  Thr Ser Phe 
    2030                 2035                 2040             


Leu Trp  Phe Thr Ser Pro Tyr  Lys Thr Met Lys Phe  Ile Leu Trp 
    2045                 2050                 2055             


Arg Arg  Phe Arg Trp Ala Ile  Ile Leu Phe Ile Ile  Leu Phe Ile 
    2060                 2065                 2070             


Leu Leu  Leu Phe Leu Ala Ile  Phe Ile Tyr Ala Phe  Pro Asn Tyr 
    2075                 2080                 2085             


Ala Ala  Met Lys Leu Val Lys  Pro Phe Ser 
    2090                 2095             


<210>  1463
<211>  2067
<212>  PRT
<213>  Homo sapiens

<400>  1463

Met Leu Cys Cys Leu Leu Val Arg Ala Ser Asn Leu Pro Ser Ala Lys 
1               5                   10                  15      


Lys Asp Arg Arg Ser Asp Pro Val Ala Ser Leu Thr Phe Arg Gly Val 
            20                  25                  30          


Lys Lys Arg Thr Lys Val Ile Lys Asn Ser Val Asn Pro Val Trp Asn 
        35                  40                  45              


Glu Gly Phe Glu Trp Asp Leu Lys Gly Ile Pro Leu Asp Gln Gly Ser 
    50                  55                  60                  


Glu Leu His Val Val Val Lys Asp His Glu Thr Met Gly Arg Asn Arg 
65                  70                  75                  80  


Phe Leu Gly Glu Ala Lys Val Pro Leu Arg Glu Val Leu Ala Thr Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Phe Asn Ala Pro Leu Leu Asp Thr Lys Lys Gln 
            100                 105                 110         


Pro Thr Gly Ala Ser Leu Val Leu Gln Val Ser Tyr Thr Pro Leu Pro 
        115                 120                 125             


Gly Ala Val Pro Leu Phe Pro Pro Pro Thr Pro Leu Glu Pro Ser Pro 
    130                 135                 140                 


Thr Leu Pro Asp Leu Asp Val Val Ala Asp Thr Gly Gly Glu Glu Asp 
145                 150                 155                 160 


Thr Glu Asp Gln Gly Leu Thr Gly Asp Glu Ala Glu Pro Phe Leu Asp 
                165                 170                 175     


Gln Ser Gly Gly Pro Gly Ala Pro Thr Thr Pro Arg Lys Leu Pro Ser 
            180                 185                 190         


Arg Pro Pro Pro His Tyr Pro Gly Ile Lys Arg Lys Arg Ser Ala Pro 
        195                 200                 205             


Thr Ser Arg Lys Leu Leu Ser Asp Lys Pro Gln Asp Phe Gln Ile Arg 
    210                 215                 220                 


Val Gln Val Ile Glu Gly Arg Gln Leu Pro Gly Val Asn Ile Lys Pro 
225                 230                 235                 240 


Val Val Lys Val Thr Ala Ala Gly Gln Thr Lys Arg Thr Arg Ile His 
                245                 250                 255     


Lys Gly Asn Ser Pro Leu Phe Asn Glu Thr Leu Phe Phe Asn Leu Phe 
            260                 265                 270         


Asp Ser Pro Gly Glu Leu Phe Asp Glu Pro Ile Phe Ile Thr Val Val 
        275                 280                 285             


Asp Ser Arg Ser Leu Arg Thr Asp Ala Leu Leu Gly Glu Phe Arg Met 
    290                 295                 300                 


Asp Val Gly Thr Ile Tyr Arg Glu Pro Arg His Ala Tyr Leu Arg Lys 
305                 310                 315                 320 


Trp Leu Leu Leu Ser Asp Pro Asp Asp Phe Ser Ala Gly Ala Arg Gly 
                325                 330                 335     


Tyr Leu Lys Thr Ser Leu Cys Val Leu Gly Pro Gly Asp Glu Ala Pro 
            340                 345                 350         


Leu Glu Arg Lys Asp Pro Ser Glu Asp Lys Glu Asp Ile Glu Ser Asn 
        355                 360                 365             


Leu Leu Arg Pro Thr Gly Val Ala Leu Arg Gly Ala His Phe Cys Leu 
    370                 375                 380                 


Lys Val Phe Arg Ala Glu Asp Leu Pro Gln Met Asp Asp Ala Val Met 
385                 390                 395                 400 


Asp Asn Val Lys Gln Ile Phe Gly Phe Glu Ser Asn Lys Lys Asn Leu 
                405                 410                 415     


Val Asp Pro Phe Val Glu Val Ser Phe Ala Gly Lys Met Leu Cys Ser 
            420                 425                 430         


Lys Ile Leu Glu Lys Thr Ala Asn Pro Gln Trp Asn Gln Asn Ile Thr 
        435                 440                 445             


Leu Pro Ala Met Phe Pro Ser Met Cys Glu Lys Met Arg Ile Arg Ile 
    450                 455                 460                 


Ile Asp Trp Asp Arg Leu Thr His Asn Asp Ile Val Ala Thr Thr Tyr 
465                 470                 475                 480 


Leu Ser Met Ser Lys Ile Ser Ala Pro Gly Gly Glu Ile Glu Val Asp 
                485                 490                 495     


Asp Tyr Leu Gly Phe Leu Pro Thr Phe Gly Pro Cys Tyr Ile Asn Leu 
            500                 505                 510         


Tyr Gly Ser Pro Arg Glu Phe Thr Gly Phe Pro Asp Pro Tyr Thr Glu 
        515                 520                 525             


Leu Asn Thr Gly Lys Gly Glu Gly Val Ala Tyr Arg Gly Arg Leu Leu 
    530                 535                 540                 


Leu Ser Leu Glu Thr Lys Leu Val Glu His Ser Glu Gln Lys Val Glu 
545                 550                 555                 560 


Asp Leu Pro Ala Asp Asp Ile Leu Arg Val Glu Lys Tyr Leu Arg Arg 
                565                 570                 575     


Arg Lys Tyr Ser Leu Phe Ala Ala Phe Tyr Ser Ala Thr Met Leu Gln 
            580                 585                 590         


Asp Val Asp Asp Ala Ile Gln Phe Glu Val Ser Ile Gly Asn Tyr Gly 
        595                 600                 605             


Asn Lys Phe Asp Met Thr Cys Leu Pro Leu Ala Ser Thr Thr Gln Tyr 
    610                 615                 620                 


Ser Arg Ala Val Phe Asp Gly Cys His Tyr Tyr Tyr Leu Pro Trp Gly 
625                 630                 635                 640 


Asn Val Lys Pro Val Val Val Leu Ser Ser Tyr Trp Glu Asp Ile Ser 
                645                 650                 655     


His Arg Ile Glu Thr Gln Asn Gln Leu Leu Gly Ile Ala Asp Arg Leu 
            660                 665                 670         


Glu Ala Gly Leu Glu Gln Val His Leu Ala Leu Lys Ala Gln Cys Ser 
        675                 680                 685             


Thr Glu Asp Val Asp Ser Leu Val Ala Gln Leu Thr Asp Glu Leu Ile 
    690                 695                 700                 


Ala Gly Cys Ser Gln Pro Leu Gly Asp Ile His Glu Thr Pro Ser Ala 
705                 710                 715                 720 


Thr His Leu Asp Gln Tyr Leu Tyr Gln Leu Arg Thr His His Leu Ser 
                725                 730                 735     


Gln Ile Thr Glu Ala Ala Leu Ala Leu Lys Leu Gly His Ser Glu Leu 
            740                 745                 750         


Pro Ala Ala Leu Glu Gln Ala Glu Asp Trp Leu Leu Arg Leu Arg Ala 
        755                 760                 765             


Leu Ala Glu Glu Pro Gln Asn Ser Leu Pro Asp Ile Val Ile Trp Met 
    770                 775                 780                 


Leu Gln Gly Asp Lys Arg Val Ala Tyr Gln Arg Val Pro Ala His Gln 
785                 790                 795                 800 


Val Leu Phe Ser Arg Arg Gly Ala Asn Tyr Cys Gly Lys Asn Cys Gly 
                805                 810                 815     


Lys Leu Gln Thr Ile Phe Leu Lys Tyr Pro Met Glu Lys Val Pro Gly 
            820                 825                 830         


Ala Arg Met Pro Val Gln Ile Arg Val Lys Leu Trp Phe Gly Leu Ser 
        835                 840                 845             


Val Asp Glu Lys Glu Phe Asn Gln Phe Ala Glu Gly Lys Leu Ser Val 
    850                 855                 860                 


Phe Ala Glu Thr Tyr Glu Asn Glu Thr Lys Leu Ala Leu Val Gly Asn 
865                 870                 875                 880 


Trp Gly Thr Thr Gly Leu Thr Tyr Pro Lys Phe Ser Asp Val Thr Gly 
                885                 890                 895     


Lys Ile Lys Leu Pro Lys Asp Ser Phe Arg Pro Ser Ala Gly Trp Thr 
            900                 905                 910         


Trp Ala Gly Asp Trp Phe Val Cys Pro Glu Lys Thr Leu Leu His Asp 
        915                 920                 925             


Met Asp Ala Gly His Leu Ser Phe Val Glu Glu Val Phe Glu Asn Gln 
    930                 935                 940                 


Thr Arg Leu Pro Gly Gly Gln Trp Ile Tyr Met Ser Asp Asn Tyr Thr 
945                 950                 955                 960 


Asp Val Asn Gly Glu Lys Val Leu Pro Lys Asp Asp Ile Glu Cys Pro 
                965                 970                 975     


Leu Gly Trp Lys Trp Glu Asp Glu Glu Trp Ser Thr Asp Leu Asn Arg 
            980                 985                 990         


Ala Val Asp Glu Gln Gly Trp Glu  Tyr Ser Ile Thr Ile  Pro Pro Glu 
        995                 1000                 1005             


Arg Lys  Pro Lys His Trp Val  Pro Ala Glu Lys Met  Tyr Tyr Thr 
    1010                 1015                 1020             


His Arg  Arg Arg Arg Trp Val  Arg Leu Arg Arg Arg  Asp Leu Ser 
    1025                 1030                 1035             


Gln Met  Glu Ala Leu Lys Arg  His Arg Gln Ala Glu  Ala Glu Gly 
    1040                 1045                 1050             


Glu Gly  Trp Glu Tyr Ala Ser  Leu Phe Gly Trp Lys  Phe His Leu 
    1055                 1060                 1065             


Glu Tyr  Arg Lys Thr Asp Ala  Phe Arg Arg Arg Arg  Trp Arg Arg 
    1070                 1075                 1080             


Arg Met  Glu Pro Leu Glu Lys  Thr Gly Pro Ala Ala  Val Phe Ala 
    1085                 1090                 1095             


Leu Glu  Gly Ala Leu Gly Gly  Val Met Asp Asp Lys  Ser Glu Asp 
    1100                 1105                 1110             


Ser Met  Ser Val Ser Thr Leu  Ser Phe Gly Val Asn  Arg Pro Thr 
    1115                 1120                 1125             


Ile Ser  Cys Ile Phe Asp Tyr  Gly Asn Arg Tyr His  Leu Arg Cys 
    1130                 1135                 1140             


Tyr Met  Tyr Gln Ala Arg Asp  Leu Ala Ala Met Asp  Lys Asp Ser 
    1145                 1150                 1155             


Phe Ser  Asp Pro Tyr Ala Ile  Val Ser Phe Leu His  Gln Ser Gln 
    1160                 1165                 1170             


Lys Thr  Val Val Val Lys Asn  Thr Leu Asn Pro Thr  Trp Asp Gln 
    1175                 1180                 1185             


Thr Leu  Ile Phe Tyr Glu Ile  Glu Ile Phe Gly Glu  Pro Ala Thr 
    1190                 1195                 1200             


Val Ala  Glu Gln Pro Pro Ser  Ile Val Val Glu Leu  Tyr Asp His 
    1205                 1210                 1215             


Asp Thr  Tyr Gly Ala Asp Glu  Phe Met Gly Arg Cys  Ile Cys Gln 
    1220                 1225                 1230             


Pro Ser  Leu Glu Arg Met Pro  Arg Leu Ala Trp Phe  Pro Leu Thr 
    1235                 1240                 1245             


Arg Gly  Ser Gln Pro Ser Gly  Glu Leu Leu Ala Ser  Phe Glu Leu 
    1250                 1255                 1260             


Ile Gln  Arg Glu Lys Pro Ala  Ile His His Ile Pro  Gly Phe Glu 
    1265                 1270                 1275             


Val Gln  Glu Thr Ser Arg Ile  Leu Asp Glu Ser Glu  Asp Thr Asp 
    1280                 1285                 1290             


Leu Pro  Tyr Pro Pro Pro Gln  Arg Glu Ala Asn Ile  Tyr Met Val 
    1295                 1300                 1305             


Pro Gln  Asn Ile Lys Pro Ala  Leu Gln Arg Thr Ala  Ile Glu Ile 
    1310                 1315                 1320             


Leu Ala  Trp Gly Leu Arg Asn  Met Lys Ser Tyr Gln  Leu Ala Asn 
    1325                 1330                 1335             


Ile Ser  Ser Pro Ser Leu Val  Val Glu Cys Gly Gly  Gln Thr Val 
    1340                 1345                 1350             


Gln Ser  Cys Val Ile Arg Asn  Leu Arg Lys Asn Pro  Asn Phe Asp 
    1355                 1360                 1365             


Ile Cys  Thr Leu Phe Met Glu  Val Met Leu Pro Arg  Glu Glu Leu 
    1370                 1375                 1380             


Tyr Cys  Pro Pro Ile Thr Val  Lys Val Ile Asp Asn  Arg Gln Phe 
    1385                 1390                 1395             


Gly Arg  Arg Pro Val Val Gly  Gln Cys Thr Ile Arg  Ser Leu Glu 
    1400                 1405                 1410             


Ser Phe  Leu Cys Asp Pro Tyr  Ser Ala Glu Ser Pro  Ser Pro Gln 
    1415                 1420                 1425             


Gly Gly  Pro Asp Asp Val Ser  Leu Leu Ser Pro Gly  Glu Asp Val 
    1430                 1435                 1440             


Leu Ile  Asp Ile Asp Asp Lys  Glu Pro Leu Ile Pro  Ile Gln Glu 
    1445                 1450                 1455             


Glu Glu  Phe Ile Asp Trp Trp  Ser Lys Phe Phe Ala  Ser Ile Gly 
    1460                 1465                 1470             


Glu Arg  Glu Lys Cys Gly Ser  Tyr Leu Glu Lys Asp  Phe Asp Thr 
    1475                 1480                 1485             


Leu Lys  Val Tyr Asp Thr Gln  Leu Glu Asn Val Glu  Ala Phe Glu 
    1490                 1495                 1500             


Gly Leu  Ser Asp Phe Cys Asn  Thr Phe Lys Leu Tyr  Arg Gly Lys 
    1505                 1510                 1515             


Thr Gln  Glu Glu Thr Glu Asp  Pro Ser Val Ile Gly  Glu Phe Lys 
    1520                 1525                 1530             


Gly Leu  Phe Lys Ile Tyr Pro  Leu Pro Glu Asp Pro  Ala Ile Pro 
    1535                 1540                 1545             


Met Pro  Pro Arg Gln Phe His  Gln Leu Ala Ala Gln  Gly Pro Gln 
    1550                 1555                 1560             


Glu Cys  Leu Val Arg Ile Tyr  Ile Val Arg Ala Phe  Gly Leu Gln 
    1565                 1570                 1575             


Pro Lys  Asp Pro Asn Gly Lys  Cys Asp Pro Tyr Ile  Lys Ile Ser 
    1580                 1585                 1590             


Ile Gly  Lys Lys Ser Val Ser  Asp Gln Asp Asn Tyr  Ile Pro Cys 
    1595                 1600                 1605             


Thr Leu  Glu Pro Val Phe Gly  Lys Met Phe Glu Leu  Thr Cys Thr 
    1610                 1615                 1620             


Leu Pro  Leu Glu Lys Asp Leu  Lys Ile Thr Leu Tyr  Asp Tyr Asp 
    1625                 1630                 1635             


Leu Leu  Ser Lys Asp Glu Lys  Ile Gly Glu Thr Val  Val Asp Leu 
    1640                 1645                 1650             


Glu Asn  Arg Leu Leu Ser Lys  Phe Gly Ala Arg Cys  Gly Leu Pro 
    1655                 1660                 1665             


Gln Thr  Tyr Cys Val Ser Gly  Pro Asn Gln Trp Arg  Asp Gln Leu 
    1670                 1675                 1680             


Arg Pro  Ser Gln Leu Leu His  Leu Phe Cys Gln Gln  His Arg Val 
    1685                 1690                 1695             


Lys Ala  Pro Val Tyr Arg Thr  Asp Arg Val Met Phe  Gln Asp Lys 
    1700                 1705                 1710             


Glu Tyr  Ser Ile Glu Glu Ile  Glu Ala Gly Arg Ile  Pro Asn Pro 
    1715                 1720                 1725             


His Leu  Gly Pro Val Glu Glu  Arg Leu Ala Leu His  Val Leu Gln 
    1730                 1735                 1740             


Gln Gln  Gly Leu Val Pro Glu  His Val Glu Ser Arg  Pro Leu Tyr 
    1745                 1750                 1755             


Ser Pro  Leu Gln Pro Asp Ile  Glu Gln Gly Lys Leu  Gln Met Trp 
    1760                 1765                 1770             


Val Asp  Leu Phe Pro Lys Ala  Leu Gly Arg Pro Gly  Pro Pro Phe 
    1775                 1780                 1785             


Asn Ile  Thr Pro Arg Arg Ala  Arg Arg Phe Phe Leu  Arg Cys Ile 
    1790                 1795                 1800             


Ile Trp  Asn Thr Arg Asp Val  Ile Leu Asp Asp Leu  Ser Leu Thr 
    1805                 1810                 1815             


Gly Glu  Lys Met Ser Asp Ile  Tyr Val Lys Gly Trp  Met Ile Gly 
    1820                 1825                 1830             


Phe Glu  Glu His Lys Gln Lys  Thr Asp Val His Tyr  Arg Ser Leu 
    1835                 1840                 1845             


Gly Gly  Glu Gly Asn Phe Asn  Trp Arg Phe Ile Phe  Pro Phe Asp 
    1850                 1855                 1860             


Tyr Leu  Pro Ala Glu Gln Val  Cys Thr Ile Ala Lys  Lys Asp Ala 
    1865                 1870                 1875             


Phe Trp  Arg Leu Asp Lys Thr  Glu Ser Lys Ile Pro  Ala Arg Val 
    1880                 1885                 1890             


Val Phe  Gln Ile Trp Asp Asn  Asp Lys Phe Ser Phe  Asp Asp Phe 
    1895                 1900                 1905             


Leu Gly  Ser Leu Gln Leu Asp  Leu Asn Arg Met Pro  Lys Pro Ala 
    1910                 1915                 1920             


Lys Thr  Ala Lys Lys Cys Ser  Leu Asp Gln Leu Asp  Asp Ala Phe 
    1925                 1930                 1935             


His Pro  Glu Trp Phe Val Ser  Leu Phe Glu Gln Lys  Thr Val Lys 
    1940                 1945                 1950             


Gly Trp  Trp Pro Cys Val Ala  Glu Glu Gly Glu Lys  Lys Ile Leu 
    1955                 1960                 1965             


Ala Gly  Lys Leu Glu Met Thr  Leu Glu Ile Val Ala  Glu Ser Glu 
    1970                 1975                 1980             


His Glu  Glu Arg Pro Ala Gly  Gln Gly Arg Asp Glu  Pro Asn Met 
    1985                 1990                 1995             


Asn Pro  Lys Leu Glu Asp Pro  Arg Arg Pro Asp Thr  Ser Phe Leu 
    2000                 2005                 2010             


Trp Phe  Thr Ser Pro Tyr Lys  Thr Met Lys Phe Ile  Leu Trp Arg 
    2015                 2020                 2025             


Arg Phe  Arg Trp Ala Ile Ile  Leu Phe Ile Ile Leu  Phe Ile Leu 
    2030                 2035                 2040             


Leu Leu  Phe Leu Ala Ile Phe  Ile Tyr Ala Phe Pro  Asn Tyr Ala 
    2045                 2050                 2055             


Ala Met  Lys Leu Val Lys Pro  Phe Ser 
    2060                 2065         


<210>  1464
<211>  2119
<212>  PRT
<213>  Homo sapiens

<400>  1464

Met Leu Cys Cys Leu Leu Val Arg Ala Ser Asn Leu Pro Ser Ala Lys 
1               5                   10                  15      


Lys Asp Arg Arg Ser Asp Pro Val Ala Ser Leu Thr Phe Arg Gly Val 
            20                  25                  30          


Lys Lys Arg Thr Lys Val Ile Lys Asn Ser Val Asn Pro Val Trp Asn 
        35                  40                  45              


Glu Gly Phe Glu Trp Asp Leu Lys Gly Ile Pro Leu Asp Gln Gly Ser 
    50                  55                  60                  


Glu Leu His Val Val Val Lys Asp His Glu Thr Met Gly Arg Asn Arg 
65                  70                  75                  80  


Phe Leu Gly Glu Ala Lys Val Pro Leu Arg Glu Val Leu Ala Thr Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Phe Asn Ala Pro Leu Leu Asp Thr Lys Lys Gln 
            100                 105                 110         


Pro Thr Gly Ala Ser Leu Val Leu Gln Val Ser Tyr Thr Pro Leu Pro 
        115                 120                 125             


Gly Ala Val Pro Leu Phe Pro Pro Pro Thr Pro Leu Glu Pro Ser Pro 
    130                 135                 140                 


Thr Leu Pro Asp Leu Asp Val Val Ala Gly Gly Gly Gln Ser Arg Ala 
145                 150                 155                 160 


Glu Thr Trp Ser Leu Leu Ser Asp Ser Thr Met Asp Thr Arg Tyr Ser 
                165                 170                 175     


Gly Lys Lys Trp Pro Ala Pro Thr Asp Thr Gly Gly Glu Glu Asp Thr 
            180                 185                 190         


Glu Asp Gln Gly Leu Thr Gly Asp Glu Ala Glu Pro Phe Leu Asp Gln 
        195                 200                 205             


Ser Gly Gly Pro Gly Ala Pro Thr Thr Pro Arg Lys Leu Pro Ser Arg 
    210                 215                 220                 


Pro Pro Pro His Tyr Pro Gly Ile Lys Arg Lys Arg Ser Ala Pro Thr 
225                 230                 235                 240 


Ser Arg Lys Leu Leu Ser Asp Lys Pro Gln Asp Phe Gln Ile Arg Val 
                245                 250                 255     


Gln Val Ile Glu Gly Arg Gln Leu Pro Gly Val Asn Ile Lys Pro Val 
            260                 265                 270         


Val Lys Val Thr Ala Ala Gly Gln Thr Lys Arg Thr Arg Ile His Lys 
        275                 280                 285             


Gly Asn Ser Pro Leu Phe Asn Glu Thr Leu Phe Phe Asn Leu Phe Asp 
    290                 295                 300                 


Ser Pro Gly Glu Leu Phe Asp Glu Pro Ile Phe Ile Thr Val Val Asp 
305                 310                 315                 320 


Ser Arg Ser Leu Arg Thr Asp Ala Leu Leu Gly Glu Phe Arg Met Asp 
                325                 330                 335     


Val Gly Thr Ile Tyr Arg Glu Pro Arg His Ala Tyr Leu Arg Lys Trp 
            340                 345                 350         


Leu Leu Leu Ser Asp Pro Asp Asp Phe Ser Ala Gly Ala Arg Gly Tyr 
        355                 360                 365             


Leu Lys Thr Ser Leu Cys Val Leu Gly Pro Gly Asp Glu Ala Pro Leu 
    370                 375                 380                 


Glu Arg Lys Asp Pro Ser Glu Asp Lys Glu Asp Ile Glu Ser Asn Leu 
385                 390                 395                 400 


Leu Arg Pro Thr Gly Val Ala Leu Arg Gly Ala His Phe Cys Leu Lys 
                405                 410                 415     


Val Phe Arg Ala Glu Asp Leu Pro Gln Met Asp Asp Ala Val Met Asp 
            420                 425                 430         


Asn Val Lys Gln Ile Phe Gly Phe Glu Ser Asn Lys Lys Asn Leu Val 
        435                 440                 445             


Asp Pro Phe Val Glu Val Ser Phe Ala Gly Lys Met Leu Cys Ser Lys 
    450                 455                 460                 


Ile Leu Glu Lys Thr Ala Asn Pro Gln Trp Asn Gln Asn Ile Thr Leu 
465                 470                 475                 480 


Pro Ala Met Phe Pro Ser Met Cys Glu Lys Met Arg Ile Arg Ile Ile 
                485                 490                 495     


Asp Trp Asp Arg Leu Thr His Asn Asp Ile Val Ala Thr Thr Tyr Leu 
            500                 505                 510         


Ser Met Ser Lys Ile Ser Ala Pro Gly Gly Glu Ile Glu Val Asp Asp 
        515                 520                 525             


Tyr Leu Gly Phe Leu Pro Thr Phe Gly Pro Cys Tyr Ile Asn Leu Tyr 
    530                 535                 540                 


Gly Ser Pro Arg Glu Phe Thr Gly Phe Pro Asp Pro Tyr Thr Glu Leu 
545                 550                 555                 560 


Asn Thr Gly Lys Gly Glu Gly Val Ala Tyr Arg Gly Arg Leu Leu Leu 
                565                 570                 575     


Ser Leu Glu Thr Lys Leu Val Glu His Ser Glu Gln Lys Val Glu Asp 
            580                 585                 590         


Leu Pro Ala Asp Asp Ile Leu Arg Val Glu Lys Tyr Leu Arg Arg Arg 
        595                 600                 605             


Lys Tyr Ser Leu Phe Ala Ala Phe Tyr Ser Ala Thr Met Leu Gln Asp 
    610                 615                 620                 


Val Asp Asp Ala Ile Gln Phe Glu Val Ser Ile Gly Asn Tyr Gly Asn 
625                 630                 635                 640 


Lys Phe Asp Met Thr Cys Leu Pro Leu Ala Ser Thr Thr Gln Tyr Ser 
                645                 650                 655     


Arg Ala Val Phe Asp Gly Cys His Tyr Tyr Tyr Leu Pro Trp Gly Asn 
            660                 665                 670         


Val Lys Pro Val Val Val Leu Ser Ser Tyr Trp Glu Asp Ile Ser His 
        675                 680                 685             


Arg Ile Glu Thr Gln Asn Gln Leu Leu Gly Ile Ala Asp Arg Leu Glu 
    690                 695                 700                 


Ala Gly Leu Glu Gln Val His Leu Ala Leu Lys Ala Gln Cys Ser Thr 
705                 710                 715                 720 


Glu Asp Val Asp Ser Leu Val Ala Gln Leu Thr Asp Glu Leu Ile Ala 
                725                 730                 735     


Gly Cys Ser Gln Pro Leu Gly Asp Ile His Glu Thr Pro Ser Ala Thr 
            740                 745                 750         


His Leu Asp Gln Tyr Leu Tyr Gln Leu Arg Thr His His Leu Ser Gln 
        755                 760                 765             


Ile Thr Glu Ala Ala Leu Ala Leu Lys Leu Gly His Ser Glu Leu Pro 
    770                 775                 780                 


Ala Ala Leu Glu Gln Ala Glu Asp Trp Leu Leu Arg Leu Arg Ala Leu 
785                 790                 795                 800 


Ala Glu Glu Pro Gln Asn Ser Leu Pro Asp Ile Val Ile Trp Met Leu 
                805                 810                 815     


Gln Gly Asp Lys Arg Val Ala Tyr Gln Arg Val Pro Ala His Gln Val 
            820                 825                 830         


Leu Phe Ser Arg Arg Gly Ala Asn Tyr Cys Gly Lys Asn Cys Gly Lys 
        835                 840                 845             


Leu Gln Thr Ile Phe Leu Lys Tyr Pro Met Glu Lys Val Pro Gly Ala 
    850                 855                 860                 


Arg Met Pro Val Gln Ile Arg Val Lys Leu Trp Phe Gly Leu Ser Val 
865                 870                 875                 880 


Asp Glu Lys Glu Phe Asn Gln Phe Ala Glu Gly Lys Leu Ser Val Phe 
                885                 890                 895     


Ala Glu Thr Tyr Glu Asn Glu Thr Lys Leu Ala Leu Val Gly Asn Trp 
            900                 905                 910         


Gly Thr Thr Gly Leu Thr Tyr Pro Lys Phe Ser Asp Val Thr Gly Lys 
        915                 920                 925             


Ile Lys Leu Pro Lys Asp Ser Phe Arg Pro Ser Ala Gly Trp Thr Trp 
    930                 935                 940                 


Ala Gly Asp Trp Phe Val Cys Pro Glu Lys Thr Leu Leu His Asp Met 
945                 950                 955                 960 


Asp Ala Gly His Leu Ser Phe Val Glu Glu Val Phe Glu Asn Gln Thr 
                965                 970                 975     


Arg Leu Pro Gly Gly Gln Trp Ile Tyr Met Ser Asp Asn Tyr Thr Asp 
            980                 985                 990         


Val Asn Gly Glu Lys Val Leu Pro  Lys Asp Asp Ile Glu  Cys Pro Leu 
        995                 1000                 1005             


Gly Trp  Lys Trp Glu Asp Glu  Glu Trp Ser Thr Asp  Leu Asn Arg 
    1010                 1015                 1020             


Ala Val  Asp Glu Gln Gly Trp  Glu Tyr Ser Ile Thr  Ile Pro Pro 
    1025                 1030                 1035             


Glu Arg  Lys Pro Lys His Trp  Val Pro Ala Glu Lys  Met Tyr Tyr 
    1040                 1045                 1050             


Thr His  Arg Arg Arg Arg Trp  Val Arg Leu Arg Arg  Arg Asp Leu 
    1055                 1060                 1065             


Ser Gln  Met Glu Ala Leu Lys  Arg His Arg Gln Ala  Glu Ala Glu 
    1070                 1075                 1080             


Gly Glu  Gly Trp Glu Tyr Ala  Ser Leu Phe Gly Trp  Lys Phe His 
    1085                 1090                 1095             


Leu Glu  Tyr Arg Lys Thr Asp  Ala Phe Arg Arg Arg  Arg Trp Arg 
    1100                 1105                 1110             


Arg Arg  Met Glu Pro Leu Glu  Lys Thr Gly Pro Ala  Ala Val Phe 
    1115                 1120                 1125             


Ala Leu  Glu Gly Ala Leu Gly  Gly Val Met Asp Asp  Lys Ser Glu 
    1130                 1135                 1140             


Asp Ser  Met Ser Val Ser Thr  Leu Ser Phe Gly Val  Asn Arg Pro 
    1145                 1150                 1155             


Thr Ile  Ser Cys Ile Phe Asp  Tyr Gly Asn Arg Tyr  His Leu Arg 
    1160                 1165                 1170             


Cys Tyr  Met Tyr Gln Ala Arg  Asp Leu Ala Ala Met  Asp Lys Asp 
    1175                 1180                 1185             


Ser Phe  Ser Asp Pro Tyr Ala  Ile Val Ser Phe Leu  His Gln Ser 
    1190                 1195                 1200             


Gln Lys  Thr Val Val Val Lys  Asn Thr Leu Asn Pro  Thr Trp Asp 
    1205                 1210                 1215             


Gln Thr  Leu Ile Phe Tyr Glu  Ile Glu Ile Phe Gly  Glu Pro Ala 
    1220                 1225                 1230             


Thr Val  Ala Glu Gln Pro Pro  Ser Ile Val Val Glu  Leu Tyr Asp 
    1235                 1240                 1245             


His Asp  Thr Tyr Gly Ala Asp  Glu Phe Met Gly Arg  Cys Ile Cys 
    1250                 1255                 1260             


Gln Pro  Ser Leu Glu Arg Met  Pro Arg Leu Ala Trp  Phe Pro Leu 
    1265                 1270                 1275             


Thr Arg  Gly Ser Gln Pro Ser  Gly Glu Leu Leu Ala  Ser Phe Glu 
    1280                 1285                 1290             


Leu Ile  Gln Arg Glu Lys Pro  Ala Ile His His Ile  Pro Gly Phe 
    1295                 1300                 1305             


Glu Val  Gln Glu Thr Ser Arg  Ile Leu Asp Glu Ser  Glu Asp Thr 
    1310                 1315                 1320             


Asp Leu  Pro Tyr Pro Pro Pro  Gln Arg Glu Ala Asn  Ile Tyr Met 
    1325                 1330                 1335             


Val Pro  Gln Asn Ile Lys Pro  Ala Leu Gln Arg Thr  Ala Ile Glu 
    1340                 1345                 1350             


Ile Leu  Ala Trp Gly Leu Arg  Asn Met Lys Ser Tyr  Gln Leu Ala 
    1355                 1360                 1365             


Asn Ile  Ser Ser Pro Ser Leu  Val Val Glu Cys Gly  Gly Gln Thr 
    1370                 1375                 1380             


Val Gln  Ser Cys Val Ile Arg  Asn Leu Arg Lys Asn  Pro Asn Phe 
    1385                 1390                 1395             


Asp Ile  Cys Thr Leu Phe Met  Glu Val Met Leu Pro  Arg Glu Glu 
    1400                 1405                 1410             


Leu Tyr  Cys Pro Pro Ile Thr  Val Lys Val Ile Asp  Asn Arg Gln 
    1415                 1420                 1425             


Phe Gly  Arg Arg Pro Val Val  Gly Gln Cys Thr Ile  Arg Ser Leu 
    1430                 1435                 1440             


Glu Ser  Phe Leu Cys Asp Pro  Tyr Ser Ala Glu Ser  Pro Ser Pro 
    1445                 1450                 1455             


Gln Gly  Gly Pro Asp Asp Val  Ser Leu Leu Ser Pro  Gly Glu Asp 
    1460                 1465                 1470             


Val Leu  Ile Asp Ile Asp Asp  Lys Glu Pro Leu Ile  Pro Ile Gln 
    1475                 1480                 1485             


Leu Ala  Asp Gly Leu Ser Ser  Leu Ala Pro Thr Asn  Thr Ala Ser 
    1490                 1495                 1500             


Pro Pro  Ser Ser Pro His Glu  Glu Glu Phe Ile Asp  Trp Trp Ser 
    1505                 1510                 1515             


Lys Phe  Phe Ala Ser Ile Gly  Glu Arg Glu Lys Cys  Gly Ser Tyr 
    1520                 1525                 1530             


Leu Glu  Lys Asp Phe Asp Thr  Leu Lys Val Tyr Asp  Thr Gln Leu 
    1535                 1540                 1545             


Glu Asn  Val Glu Ala Phe Glu  Gly Leu Ser Asp Phe  Cys Asn Thr 
    1550                 1555                 1560             


Phe Lys  Leu Tyr Arg Gly Lys  Thr Gln Glu Glu Thr  Glu Asp Pro 
    1565                 1570                 1575             


Ser Val  Ile Gly Glu Phe Lys  Gly Leu Phe Lys Ile  Tyr Pro Leu 
    1580                 1585                 1590             


Pro Glu  Asp Pro Ala Ile Pro  Met Pro Pro Arg Gln  Phe His Gln 
    1595                 1600                 1605             


Leu Ala  Ala Gln Gly Pro Gln  Glu Cys Leu Val Arg  Ile Tyr Ile 
    1610                 1615                 1620             


Val Arg  Ala Phe Gly Leu Gln  Pro Lys Asp Pro Asn  Gly Lys Cys 
    1625                 1630                 1635             


Asp Pro  Tyr Ile Lys Ile Ser  Ile Gly Lys Lys Ser  Val Ser Asp 
    1640                 1645                 1650             


Gln Asp  Asn Tyr Ile Pro Cys  Thr Leu Glu Pro Val  Phe Gly Lys 
    1655                 1660                 1665             


Met Phe  Glu Leu Thr Cys Thr  Leu Pro Leu Glu Lys  Asp Leu Lys 
    1670                 1675                 1680             


Ile Thr  Leu Tyr Asp Tyr Asp  Leu Leu Ser Lys Asp  Glu Lys Ile 
    1685                 1690                 1695             


Gly Glu  Thr Val Val Asp Leu  Glu Asn Arg Leu Leu  Ser Lys Phe 
    1700                 1705                 1710             


Gly Ala  Arg Cys Gly Leu Pro  Gln Thr Tyr Cys Val  Ser Gly Pro 
    1715                 1720                 1725             


Asn Gln  Trp Arg Asp Gln Leu  Arg Pro Ser Gln Leu  Leu His Leu 
    1730                 1735                 1740             


Phe Cys  Gln Gln His Arg Val  Lys Ala Pro Val Tyr  Arg Thr Asp 
    1745                 1750                 1755             


Arg Val  Met Phe Gln Asp Lys  Glu Tyr Ser Ile Glu  Glu Ile Glu 
    1760                 1765                 1770             


Ala Gly  Arg Ile Pro Asn Pro  His Leu Gly Pro Val  Glu Glu Arg 
    1775                 1780                 1785             


Leu Ala  Leu His Val Leu Gln  Gln Gln Gly Leu Val  Pro Glu His 
    1790                 1795                 1800             


Val Glu  Ser Arg Pro Leu Tyr  Ser Pro Leu Gln Pro  Asp Ile Glu 
    1805                 1810                 1815             


Gln Gly  Lys Leu Gln Met Trp  Val Asp Leu Phe Pro  Lys Ala Leu 
    1820                 1825                 1830             


Gly Arg  Pro Gly Pro Pro Phe  Asn Ile Thr Pro Arg  Arg Ala Arg 
    1835                 1840                 1845             


Arg Phe  Phe Leu Arg Cys Ile  Ile Trp Asn Thr Arg  Asp Val Ile 
    1850                 1855                 1860             


Leu Asp  Asp Leu Ser Leu Thr  Gly Glu Lys Met Ser  Asp Ile Tyr 
    1865                 1870                 1875             


Val Lys  Gly Trp Met Ile Gly  Phe Glu Glu His Lys  Gln Lys Thr 
    1880                 1885                 1890             


Asp Val  His Tyr Arg Ser Leu  Gly Gly Glu Gly Asn  Phe Asn Trp 
    1895                 1900                 1905             


Arg Phe  Ile Phe Pro Phe Asp  Tyr Leu Pro Ala Glu  Gln Val Cys 
    1910                 1915                 1920             


Thr Ile  Ala Lys Lys Asp Ala  Phe Trp Arg Leu Asp  Lys Thr Glu 
    1925                 1930                 1935             


Ser Lys  Ile Pro Ala Arg Val  Val Phe Gln Ile Trp  Asp Asn Asp 
    1940                 1945                 1950             


Lys Phe  Ser Phe Asp Asp Phe  Leu Gly Ser Leu Gln  Leu Asp Leu 
    1955                 1960                 1965             


Asn Arg  Met Pro Lys Pro Ala  Lys Thr Ala Lys Lys  Cys Ser Leu 
    1970                 1975                 1980             


Asp Gln  Leu Asp Asp Ala Phe  His Pro Glu Trp Phe  Val Ser Leu 
    1985                 1990                 1995             


Phe Glu  Gln Lys Thr Val Lys  Gly Trp Trp Pro Cys  Val Ala Glu 
    2000                 2005                 2010             


Glu Gly  Glu Lys Lys Ile Leu  Ala Gly Lys Leu Glu  Met Thr Leu 
    2015                 2020                 2025             


Glu Ile  Val Ala Glu Ser Glu  His Glu Glu Arg Pro  Ala Gly Gln 
    2030                 2035                 2040             


Gly Arg  Asp Glu Pro Asn Met  Asn Pro Lys Leu Glu  Asp Pro Arg 
    2045                 2050                 2055             


Arg Pro  Asp Thr Ser Phe Leu  Trp Phe Thr Ser Pro  Tyr Lys Thr 
    2060                 2065                 2070             


Met Lys  Phe Ile Leu Trp Arg  Arg Phe Arg Trp Ala  Ile Ile Leu 
    2075                 2080                 2085             


Phe Ile  Ile Leu Phe Ile Leu  Leu Leu Phe Leu Ala  Ile Phe Ile 
    2090                 2095                 2100             


Tyr Ala  Phe Pro Asn Tyr Ala  Ala Met Lys Leu Val  Lys Pro Phe 
    2105                 2110                 2115             


Ser 
    


<210>  1465
<211>  999
<212>  PRT
<213>  Homo sapiens

<400>  1465

Met Ala Asp Lys Val Arg Arg Gln Arg Pro Arg Arg Arg Val Cys Trp 
1               5                   10                  15      


Ala Leu Val Ala Val Leu Leu Ala Asp Leu Leu Ala Leu Ser Asp Thr 
            20                  25                  30          


Leu Ala Val Met Ser Val Asp Leu Gly Ser Glu Ser Met Lys Val Ala 
        35                  40                  45              


Ile Val Lys Pro Gly Val Pro Met Glu Ile Val Leu Asn Lys Glu Ser 
    50                  55                  60                  


Arg Arg Lys Thr Pro Val Ile Val Thr Leu Lys Glu Asn Glu Arg Phe 
65                  70                  75                  80  


Phe Gly Asp Ser Ala Ala Ser Met Ala Ile Lys Asn Pro Lys Ala Thr 
                85                  90                  95      


Leu Arg Tyr Phe Gln His Leu Leu Gly Lys Gln Ala Asp Asn Pro His 
            100                 105                 110         


Val Ala Leu Tyr Gln Ala Arg Phe Pro Glu His Glu Leu Thr Phe Asp 
        115                 120                 125             


Pro Gln Arg Gln Thr Val His Phe Gln Ile Ser Ser Gln Leu Gln Phe 
    130                 135                 140                 


Ser Pro Glu Glu Val Leu Gly Met Val Leu Asn Tyr Ser Arg Ser Leu 
145                 150                 155                 160 


Ala Glu Asp Phe Ala Glu Gln Pro Ile Lys Asp Ala Val Ile Thr Val 
                165                 170                 175     


Pro Val Phe Phe Asn Gln Ala Glu Arg Arg Ala Val Leu Gln Ala Ala 
            180                 185                 190         


Arg Met Ala Gly Leu Lys Val Leu Gln Leu Ile Asn Asp Asn Thr Ala 
        195                 200                 205             


Thr Ala Leu Ser Tyr Gly Val Phe Arg Arg Lys Asp Ile Asn Thr Thr 
    210                 215                 220                 


Ala Gln Asn Ile Met Phe Tyr Asp Met Gly Ser Gly Ser Thr Val Cys 
225                 230                 235                 240 


Thr Ile Val Thr Tyr Gln Met Val Lys Thr Lys Glu Ala Gly Met Gln 
                245                 250                 255     


Pro Gln Leu Gln Ile Arg Gly Val Gly Phe Asp Arg Thr Leu Gly Gly 
            260                 265                 270         


Leu Glu Met Glu Leu Arg Leu Arg Glu Arg Leu Ala Gly Leu Phe Asn 
        275                 280                 285             


Glu Gln Arg Lys Gly Gln Arg Ala Lys Asp Val Arg Glu Asn Pro Arg 
    290                 295                 300                 


Ala Met Ala Lys Leu Leu Arg Glu Ala Asn Arg Leu Lys Thr Val Leu 
305                 310                 315                 320 


Ser Ala Asn Ala Asp His Met Ala Gln Ile Glu Gly Leu Met Asp Asp 
                325                 330                 335     


Val Asp Phe Lys Ala Lys Val Thr Arg Val Glu Phe Glu Glu Leu Cys 
            340                 345                 350         


Ala Asp Leu Phe Glu Arg Val Pro Gly Pro Val Gln Gln Ala Leu Gln 
        355                 360                 365             


Ser Ala Glu Met Ser Leu Asp Glu Ile Glu Gln Val Ile Leu Val Gly 
    370                 375                 380                 


Gly Ala Thr Arg Val Pro Arg Val Gln Glu Val Leu Leu Lys Ala Val 
385                 390                 395                 400 


Gly Lys Glu Glu Leu Gly Lys Asn Ile Asn Ala Asp Glu Ala Ala Ala 
                405                 410                 415     


Met Gly Ala Val Tyr Gln Ala Ala Ala Leu Ser Lys Ala Phe Lys Val 
            420                 425                 430         


Lys Pro Phe Val Val Arg Asp Ala Val Val Tyr Pro Ile Leu Val Glu 
        435                 440                 445             


Phe Thr Arg Glu Val Glu Glu Glu Pro Gly Ile His Ser Leu Lys His 
    450                 455                 460                 


Asn Lys Arg Val Leu Phe Ser Arg Met Gly Pro Tyr Pro Gln Arg Lys 
465                 470                 475                 480 


Val Ile Thr Phe Asn Arg Tyr Ser His Asp Phe Asn Phe His Ile Asn 
                485                 490                 495     


Tyr Gly Asp Leu Gly Phe Leu Gly Pro Glu Asp Leu Arg Val Phe Gly 
            500                 505                 510         


Ser Gln Asn Leu Thr Thr Val Lys Leu Lys Gly Val Gly Asp Ser Phe 
        515                 520                 525             


Lys Lys Tyr Pro Asp Tyr Glu Ser Lys Gly Ile Lys Ala His Phe Asn 
    530                 535                 540                 


Leu Asp Glu Ser Gly Val Leu Ser Leu Asp Arg Val Glu Ser Val Phe 
545                 550                 555                 560 


Glu Thr Leu Val Glu Asp Ser Ala Glu Glu Glu Ser Thr Leu Thr Lys 
                565                 570                 575     


Leu Gly Asn Thr Ile Ser Ser Leu Phe Gly Gly Gly Thr Thr Pro Asp 
            580                 585                 590         


Ala Lys Glu Asn Gly Thr Asp Thr Val Gln Glu Glu Glu Glu Ser Pro 
        595                 600                 605             


Ala Glu Gly Ser Lys Asp Glu Pro Gly Glu Gln Val Glu Leu Lys Glu 
    610                 615                 620                 


Glu Ala Glu Ala Pro Val Glu Asp Gly Ser Gln Pro Pro Pro Pro Glu 
625                 630                 635                 640 


Pro Lys Gly Asp Ala Thr Pro Glu Gly Glu Lys Ala Thr Glu Lys Glu 
                645                 650                 655     


Asn Gly Asp Lys Ser Glu Ala Gln Lys Pro Ser Glu Lys Ala Glu Ala 
            660                 665                 670         


Gly Pro Glu Gly Val Ala Pro Ala Pro Glu Gly Glu Lys Lys Gln Lys 
        675                 680                 685             


Pro Ala Arg Lys Arg Arg Met Val Glu Glu Ile Gly Val Glu Leu Val 
    690                 695                 700                 


Val Leu Asp Leu Pro Asp Leu Pro Glu Asp Lys Leu Ala Gln Ser Val 
705                 710                 715                 720 


Gln Lys Leu Gln Asp Leu Thr Leu Arg Asp Leu Glu Lys Gln Glu Arg 
                725                 730                 735     


Glu Lys Ala Ala Asn Ser Leu Glu Ala Phe Ile Phe Glu Thr Gln Asp 
            740                 745                 750         


Lys Leu Tyr Gln Pro Glu Tyr Gln Glu Val Ser Thr Glu Glu Gln Arg 
        755                 760                 765             


Glu Glu Ile Ser Gly Lys Leu Ser Ala Ala Ser Thr Trp Leu Glu Asp 
    770                 775                 780                 


Glu Gly Val Gly Ala Thr Thr Val Met Leu Lys Glu Lys Leu Ala Glu 
785                 790                 795                 800 


Leu Arg Lys Leu Cys Gln Gly Leu Phe Phe Arg Val Glu Glu Arg Lys 
                805                 810                 815     


Lys Trp Pro Glu Arg Leu Ser Ala Leu Asp Asn Leu Leu Asn His Ser 
            820                 825                 830         


Ser Met Phe Leu Lys Gly Ala Arg Leu Ile Pro Glu Met Asp Gln Ile 
        835                 840                 845             


Phe Thr Glu Val Glu Met Thr Thr Leu Glu Lys Val Ile Asn Glu Thr 
    850                 855                 860                 


Trp Ala Trp Lys Asn Ala Thr Leu Ala Glu Gln Ala Lys Leu Pro Ala 
865                 870                 875                 880 


Thr Glu Lys Pro Val Leu Leu Ser Lys Asp Ile Glu Ala Lys Met Met 
                885                 890                 895     


Ala Leu Asp Arg Glu Val Gln Tyr Leu Leu Asn Lys Ala Lys Phe Thr 
            900                 905                 910         


Lys Pro Arg Pro Arg Pro Lys Asp Lys Asn Gly Thr Arg Ala Glu Pro 
        915                 920                 925             


Pro Leu Asn Ala Ser Ala Ser Asp Gln Gly Glu Lys Val Ile Pro Pro 
    930                 935                 940                 


Ala Gly Gln Thr Glu Asp Ala Glu Pro Ile Ser Glu Pro Glu Lys Val 
945                 950                 955                 960 


Glu Thr Gly Ser Glu Pro Gly Asp Thr Glu Pro Leu Glu Leu Gly Gly 
                965                 970                 975     


Pro Gly Ala Glu Pro Glu Gln Lys Glu Gln Ser Thr Gly Gln Lys Arg 
            980                 985                 990         


Pro Leu Lys Asn Asp Glu Leu 
        995                 


<210>  1466
<211>  835
<212>  PRT
<213>  Homo sapiens

<400>  1466

Met Leu Ser Arg Leu Phe Arg Met His Gly Leu Phe Val Ala Ser His 
1               5                   10                  15      


Pro Trp Glu Val Ile Val Gly Thr Val Thr Leu Thr Ile Cys Met Met 
            20                  25                  30          


Ser Met Asn Met Phe Thr Gly Asn Asn Lys Ile Cys Gly Trp Asn Tyr 
        35                  40                  45              


Glu Cys Pro Lys Phe Glu Glu Asp Val Leu Ser Ser Asp Ile Ile Ile 
    50                  55                  60                  


Leu Thr Ile Thr Arg Cys Ile Ala Ile Leu Tyr Ile Tyr Phe Gln Phe 
65                  70                  75                  80  


Gln Asn Leu Arg Gln Leu Gly Ser Lys Tyr Ile Leu Gly Ile Ala Gly 
                85                  90                  95      


Leu Phe Thr Ile Phe Ser Ser Phe Val Phe Ser Thr Val Val Ile His 
            100                 105                 110         


Phe Leu Asp Lys Glu Leu Thr Gly Leu Asn Glu Ala Leu Pro Phe Phe 
        115                 120                 125             


Leu Leu Leu Ile Asp Leu Ser Arg Ala Ser Thr Leu Ala Lys Phe Ala 
    130                 135                 140                 


Leu Ser Ser Asn Ser Gln Asp Glu Val Arg Glu Asn Ile Ala Arg Gly 
145                 150                 155                 160 


Met Ala Ile Leu Gly Pro Thr Phe Thr Leu Asp Ala Leu Val Glu Cys 
                165                 170                 175     


Leu Val Ile Gly Val Gly Thr Met Ser Gly Val Arg Gln Leu Glu Ile 
            180                 185                 190         


Met Cys Cys Phe Gly Cys Met Ser Val Leu Ala Asn Tyr Phe Val Phe 
        195                 200                 205             


Met Thr Phe Phe Pro Ala Cys Val Ser Leu Val Leu Glu Leu Ser Arg 
    210                 215                 220                 


Glu Ser Arg Glu Gly Arg Pro Ile Trp Gln Leu Ser His Phe Ala Arg 
225                 230                 235                 240 


Val Leu Glu Glu Glu Glu Asn Lys Pro Asn Pro Val Thr Gln Arg Val 
                245                 250                 255     


Lys Met Ile Met Ser Leu Gly Leu Val Leu Val His Ala His Ser Arg 
            260                 265                 270         


Trp Ile Ala Asp Pro Ser Pro Gln Asn Ser Thr Ala Asp Thr Ser Lys 
        275                 280                 285             


Val Ser Leu Gly Leu Asp Glu Asn Val Ser Lys Arg Ile Glu Pro Ser 
    290                 295                 300                 


Val Ser Leu Trp Gln Phe Tyr Leu Ser Lys Met Ile Ser Met Asp Ile 
305                 310                 315                 320 


Glu Gln Val Ile Thr Leu Ser Leu Ala Leu Leu Leu Ala Val Lys Tyr 
                325                 330                 335     


Ile Phe Phe Glu Gln Thr Glu Thr Glu Ser Thr Leu Ser Leu Lys Asn 
            340                 345                 350         


Pro Ile Thr Ser Pro Val Val Thr Gln Lys Lys Val Pro Asp Asn Cys 
        355                 360                 365             


Cys Arg Arg Glu Pro Met Leu Val Arg Asn Asn Gln Lys Cys Asp Ser 
    370                 375                 380                 


Val Glu Glu Glu Thr Gly Ile Asn Arg Glu Arg Lys Val Glu Val Ile 
385                 390                 395                 400 


Lys Pro Leu Val Ala Glu Thr Asp Thr Pro Asn Arg Ala Thr Phe Val 
                405                 410                 415     


Val Gly Asn Ser Ser Leu Leu Asp Thr Ser Ser Val Leu Val Thr Gln 
            420                 425                 430         


Glu Pro Glu Ile Glu Leu Pro Arg Glu Pro Arg Pro Asn Glu Glu Cys 
        435                 440                 445             


Leu Gln Ile Leu Gly Asn Ala Glu Lys Gly Ala Lys Phe Leu Ser Asp 
    450                 455                 460                 


Ala Glu Ile Ile Gln Leu Val Asn Ala Lys His Ile Pro Ala Tyr Lys 
465                 470                 475                 480 


Leu Glu Thr Leu Met Glu Thr His Glu Arg Gly Val Ser Ile Arg Arg 
                485                 490                 495     


Gln Leu Leu Ser Lys Lys Leu Ser Glu Pro Ser Ser Leu Gln Tyr Leu 
            500                 505                 510         


Pro Tyr Arg Asp Tyr Asn Tyr Ser Leu Leu Gly Gly Gly Ala Ser Ser 
        515                 520                 525             


Arg Val Leu Ala Asp Gly Met Thr Arg Gly Pro Val Val Arg Leu Pro 
    530                 535                 540                 


Arg Ala Cys Asp Ser Ala Glu Val Lys Ala Trp Leu Glu Thr Ser Glu 
545                 550                 555                 560 


Gly Phe Ala Val Ile Lys Glu Ala Phe Asp Ser Thr Ser Arg Phe Ala 
                565                 570                 575     


Arg Leu Gln Lys Leu His Thr Ser Ile Ala Gly Arg Asn Leu Tyr Ile 
            580                 585                 590         


Arg Phe Gln Ser Arg Ser Gly Asp Ala Met Gly Met Asn Met Ile Ser 
        595                 600                 605             


Lys Gly Thr Glu Lys Ala Leu Ser Lys Leu His Glu Tyr Phe Pro Glu 
    610                 615                 620                 


Met Gln Ile Leu Ala Val Ser Gly Asn Tyr Cys Thr Asp Lys Lys Pro 
625                 630                 635                 640 


Ala Ala Ile Asn Trp Ile Glu Gly Arg Gly Lys Ser Val Val Cys Glu 
                645                 650                 655     


Ala Val Ile Pro Ala Lys Val Val Arg Glu Val Leu Lys Thr Thr Thr 
            660                 665                 670         


Glu Ala Met Ile Glu Val Asn Ile Asn Lys Asn Leu Val Gly Ser Ala 
        675                 680                 685             


Met Ala Gly Ser Ile Gly Gly Tyr Asn Ala His Ala Ala Asn Ile Val 
    690                 695                 700                 


Thr Ala Ile Tyr Ile Ala Cys Gly Gln Asp Ala Ala Gln Asn Val Gly 
705                 710                 715                 720 


Ser Ser Asn Cys Ile Thr Leu Met Glu Ala Ser Gly Pro Thr Asn Glu 
                725                 730                 735     


Asp Leu Tyr Ile Ser Cys Thr Met Pro Ser Ile Glu Ile Gly Thr Val 
            740                 745                 750         


Gly Gly Gly Thr Asn Leu Leu Pro Gln Gln Ala Cys Leu Gln Met Leu 
        755                 760                 765             


Gly Val Gln Gly Ala Cys Lys Asp Asn Pro Gly Glu Asn Ala Arg Gln 
    770                 775                 780                 


Leu Ala Arg Ile Val Cys Gly Thr Val Met Ala Gly Glu Leu Ser Leu 
785                 790                 795                 800 


Met Ala Ala Leu Ala Ala Gly His Leu Val Lys Ser His Met Ile His 
                805                 810                 815     


Asn Arg Ser Lys Ile Asn Leu Gln Asp Leu Gln Gly Ala Cys Thr Lys 
            820                 825                 830         


Lys Thr Ala 
        835 


<210>  1467
<211>  397
<212>  PRT
<213>  Homo sapiens

<400>  1467

Met Ala Pro Asn Gly Thr Ala Ser Ser Phe Cys Leu Asp Ser Thr Ala 
1               5                   10                  15      


Cys Lys Ile Thr Ile Thr Val Val Leu Ala Val Leu Ile Leu Ile Thr 
            20                  25                  30          


Val Ala Gly Asn Val Val Val Cys Leu Ala Val Gly Leu Asn Arg Arg 
        35                  40                  45              


Leu Arg Asn Leu Thr Asn Cys Phe Ile Val Ser Leu Ala Ile Thr Asp 
    50                  55                  60                  


Leu Leu Leu Gly Leu Leu Val Leu Pro Phe Ser Ala Ile Tyr Gln Leu 
65                  70                  75                  80  


Ser Cys Lys Trp Ser Phe Gly Lys Val Phe Cys Asn Ile Tyr Thr Ser 
                85                  90                  95      


Leu Asp Val Met Leu Cys Thr Ala Ser Ile Leu Asn Leu Phe Met Ile 
            100                 105                 110         


Ser Leu Asp Arg Tyr Cys Ala Val Met Asp Pro Leu Arg Tyr Pro Val 
        115                 120                 125             


Leu Val Thr Pro Val Arg Val Ala Ile Ser Leu Val Leu Ile Trp Val 
    130                 135                 140                 


Ile Ser Ile Thr Leu Ser Phe Leu Ser Ile His Leu Gly Trp Asn Ser 
145                 150                 155                 160 


Arg Asn Glu Thr Ser Lys Gly Asn His Thr Thr Ser Lys Cys Lys Val 
                165                 170                 175     


Gln Val Asn Glu Val Tyr Gly Leu Val Asp Gly Leu Val Thr Phe Tyr 
            180                 185                 190         


Leu Pro Leu Leu Ile Met Cys Ile Thr Tyr Tyr Arg Ile Phe Lys Val 
        195                 200                 205             


Ala Arg Asp Gln Ala Lys Arg Ile Asn His Ile Ser Ser Trp Lys Ala 
    210                 215                 220                 


Ala Thr Ile Arg Glu His Lys Ala Thr Val Thr Leu Ala Ala Val Met 
225                 230                 235                 240 


Gly Ala Phe Ile Ile Cys Trp Phe Pro Tyr Phe Thr Ala Phe Val Tyr 
                245                 250                 255     


Arg Gly Leu Arg Gly Asp Asp Ala Ile Asn Glu Val Leu Glu Ala Ile 
            260                 265                 270         


Val Leu Trp Leu Gly Tyr Ala Asn Ser Ala Leu Asn Pro Ile Leu Tyr 
        275                 280                 285             


Ala Ala Leu Asn Arg Asp Phe Arg Thr Gly Tyr Gln Gln Leu Phe Cys 
    290                 295                 300                 


Cys Arg Leu Ala Asn Arg Asn Ser His Lys Thr Ser Leu Arg Ser Asn 
305                 310                 315                 320 


Ala Ser Gln Leu Ser Arg Thr Gln Ser Arg Glu Pro Arg Gln Gln Glu 
                325                 330                 335     


Glu Lys Pro Leu Lys Leu Gln Val Trp Ser Gly Thr Glu Val Thr Ala 
            340                 345                 350         


Pro Gln Gly Ala Thr Asp Arg Pro Trp Leu Cys Leu Pro Glu Cys Trp 
        355                 360                 365             


Ser Val Glu Leu Thr His Ser Phe Ile His Leu Phe Ile His Ser Phe 
    370                 375                 380                 


Ala Asn Ile His Pro Ile Pro Thr Thr Cys Gln Glu Leu 
385                 390                 395         


<210>  1468
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  1468

Met Gly Val Arg Met Thr Glu Tyr Val Gly Leu Tyr Arg His Gly Asp 
1               5                   10                  15      


Arg Ser Pro Val Lys Thr Tyr Pro Lys Asp Pro Tyr Gln Glu Glu Glu 
            20                  25                  30          


Trp Pro Gln Gly Phe Gly Gln Leu Thr Lys Glu Gly Met Leu Gln His 
        35                  40                  45              


Trp Glu Leu Gly Gln Ala Leu Arg Gln Arg Tyr His Gly Phe Leu Asn 
    50                  55                  60                  


Thr Ser Tyr His Arg Gln Glu Val Tyr Val Arg Ser Thr Asp Phe Asp 
65                  70                  75                  80  


Arg Thr Leu Met Ser Ala Glu Ala Asn Leu Ala Gly Leu Phe Pro Pro 
                85                  90                  95      


Asn Gly Met Gln Arg Phe Asn Pro Asn Ile Ser Trp Gln Pro Ile Pro 
            100                 105                 110         


Val His Thr Val Pro Ile Thr Glu Asp Arg Leu Leu Lys Phe Pro Leu 
        115                 120                 125             


Gly Pro Cys Pro Arg Tyr Glu Gln Leu Gln Asn Glu Thr Arg Gln Thr 
    130                 135                 140                 


Pro Glu Tyr Gln Asn Glu Ser Ser Arg Asn Ala Gln Phe Leu Asp Met 
145                 150                 155                 160 


Val Ala Asn Glu Thr Gly Leu Thr Asp Leu Thr Leu Glu Thr Val Trp 
                165                 170                 175     


Asn Val Tyr Asp Thr Leu Phe Cys Glu Gln Thr His Gly Leu Arg Leu 
            180                 185                 190         


Pro Pro Trp Ala Ser Pro Gln Thr Met Gln Arg Leu Ser Arg Leu Lys 
        195                 200                 205             


Asp Phe Ser Phe Arg Phe Leu Phe Gly Ile Tyr Gln Gln Ala Glu Lys 
    210                 215                 220                 


Ala Arg Leu Gln Gly Gly Val Leu Leu Ala Gln Ile Arg Lys Asn Leu 
225                 230                 235                 240 


Thr Leu Met Ala Thr Thr Ser Gln Leu Pro Lys Leu Leu Val Tyr Ser 
                245                 250                 255     


Ala His Asp Thr Thr Leu Val Ala Leu Gln Met Ala Leu Asp Val Tyr 
            260                 265                 270         


Asn Gly Glu Gln Ala Pro Tyr Ala Ser Cys His Ile Phe Glu Leu Tyr 
        275                 280                 285             


Gln Glu Asp Ser Gly Asn Phe Ser Val Glu Met Tyr Phe Arg Asn Glu 
    290                 295                 300                 


Ser Asp Lys Ala Pro Trp Pro Leu Ser Leu Pro Gly Cys Pro His Arg 
305                 310                 315                 320 


Cys Pro Leu Gln Asp Phe Leu Arg Leu Thr Glu Pro Val Val Pro Lys 
                325                 330                 335     


Asp Trp Gln Gln Glu Cys Gln Leu Ala Ser Gly Pro Ala Asp Thr Glu 
            340                 345                 350         


Val Ile Val Ala Leu Ala Val Cys Gly Ser Ile Leu Phe Leu Leu Ile 
        355                 360                 365             


Val Leu Leu Leu Thr Val Leu Phe Arg Met Gln Ala Gln Pro Pro Gly 
    370                 375                 380                 


Tyr Arg His Val Ala Asp Gly Glu Asp His Ala 
385                 390                 395 


<210>  1469
<211>  832
<212>  PRT
<213>  Homo sapiens

<400>  1469

Met His Lys His Tyr Lys Val His Phe Ala Lys Asp Ala Gln Ser Pro 
1               5                   10                  15      


Asn Gly His Tyr Phe Trp Asp Pro Glu Leu Gly His Arg Lys Gly Cys 
            20                  25                  30          


Cys His Gln Trp Arg Gln Asp Ser Ala Ala Leu Arg Ala His Gly Pro 
        35                  40                  45              


Cys Arg Pro Ser Pro Gln Ser His Trp Gln Leu Ala Tyr His Ser His 
    50                  55                  60                  


Gln Val Gly Gly Ser Gly Trp Arg Arg Gly Leu Leu Pro Ser Val Leu 
65                  70                  75                  80  


Gln Gln Gln Arg Gln Pro Gln Ser Gln Pro Ser Pro Pro Ser Pro Leu 
                85                  90                  95      


Arg Gln Arg Leu Cys Pro Ile His Glu Ala Gln Lys Gly Leu Pro Ala 
            100                 105                 110         


Thr Ser Thr Val Pro Lys Glu Pro Ala Ser Ala Pro Gln Ala Pro Thr 
        115                 120                 125             


Leu Pro Thr Thr Ala Pro Ala Met Ala Arg Ser Gly Pro Ala Leu Pro 
    130                 135                 140                 


Ser Ala Ala Gly Val Leu Leu Lys Pro Ser Glu Pro Thr Asp Ala Arg 
145                 150                 155                 160 


Pro Leu Pro Ala Pro Ala Ala Cys Gly Ser Phe Thr Ala Tyr Ser Ser 
                165                 170                 175     


Asp Ile Leu Thr Glu Asp Asp Val Tyr Cys Ser Cys Leu Ala Lys Thr 
            180                 185                 190         


Leu Cys His Val Pro Val Pro Val Thr Val Gly Phe Tyr Ala Pro Phe 
        195                 200                 205             


Gly Cys Arg Leu His Met Met Leu Asp Lys Ile Thr Ala Leu Met Gln 
    210                 215                 220                 


Gln Glu Ala Ala Gln Arg Glu Ser Glu Glu Leu Gln His Val Gln Trp 
225                 230                 235                 240 


Arg Pro Arg Ala Val Ser Gly Trp Gly Val Pro Gln Leu Leu Trp Tyr 
                245                 250                 255     


Leu Val Phe Leu Gln Pro Ile Ile Thr Glu Val His Leu Arg Arg Arg 
            260                 265                 270         


Asn Val Gln Phe Leu Phe Ile Arg Phe Ser Ala Trp Gln Tyr Ala Gly 
        275                 280                 285             


Thr Asp Lys Leu Trp Ala Gly Leu Val Thr Thr Leu Cys Glu Gly Ile 
    290                 295                 300                 


Arg Arg His Tyr Gly Ala Leu Pro Phe Ser Val Tyr Ser Val Leu Gly 
305                 310                 315                 320 


Asn Lys Pro Ala Thr Arg Gln Asp Cys Cys Gln Ser Glu Trp His Cys 
                325                 330                 335     


Arg Arg Arg Val Cys Leu Gly Leu Leu Ala Leu Leu Ala Ala Leu Gly 
            340                 345                 350         


Leu Gly Val Gly Leu Leu Tyr Leu Ser Leu Gly Gly His Ala Leu Gly 
        355                 360                 365             


His Gly Ser Pro Ser Gly Ser Leu Leu Lys Val Phe Gly Gly Ala Ala 
    370                 375                 380                 


Thr Thr Leu Ser Gly Ser Gly Leu Leu Met Ala Val Tyr Ser Val Gly 
385                 390                 395                 400 


Lys His Leu Phe Val Ser Gln Arg Lys Lys Ile Glu Arg Leu Val Ser 
                405                 410                 415     


Arg Glu Lys Phe Gly Ser Gln Leu Gly Phe Met Cys Glu Val Lys Lys 
            420                 425                 430         


Glu Val Glu Leu Leu Thr Asp Phe Leu Cys Phe Leu Glu Ile Tyr Gln 
        435                 440                 445             


Arg Arg Arg Leu Arg Val Val Leu Glu Val Thr Gly Leu Asp Thr Cys 
    450                 455                 460                 


Tyr Pro Glu Arg Val Val Gly Val Leu Asn Ala Ile Asn Thr Leu Leu 
465                 470                 475                 480 


Ser Asp Ser His Ala Pro Phe Ile Phe Ile Leu Val Val Asp Pro Ser 
                485                 490                 495     


Ile Leu Ala Ala Cys Leu Glu Ser Ala Gly Asn Met Lys Gly Thr Ala 
            500                 505                 510         


Asp Asn Gly Tyr Leu Phe Leu Asn Arg Thr Val Thr Leu Pro Phe Ser 
        515                 520                 525             


Val Pro Ile Met Gly Arg Arg Thr Lys Leu Gln Phe Leu His Asp Ala 
    530                 535                 540                 


Val Gln Ser Arg Asp Asp Leu Leu Tyr Arg Glu Met Thr Arg Lys Pro 
545                 550                 555                 560 


Trp Leu Pro Gly Asp Ala Gly Gly Glu Ser Ala Gln Leu Leu Ala Val 
                565                 570                 575     


Gln Ala Gln Ala Gly Thr Glu Arg Gly Gln Gly Arg Ile Asp Asp Glu 
            580                 585                 590         


Ala Ala Arg Arg Ile Gln Glu Ala Leu Phe Cys Leu His Asp Glu Arg 
        595                 600                 605             


Asp Cys Leu Tyr Glu Tyr Val Pro Asp Asn Val Val Ser Met Arg Arg 
    610                 615                 620                 


Ile Val Asn Thr Val Pro Ile Thr Val Arg Leu Leu Gln Gln Gln Gln 
625                 630                 635                 640 


Gln Gln Gly Asp Phe Gly Gly Pro Thr Pro Arg Gln Ala Val Ala Trp 
                645                 650                 655     


Val Val Leu Ala Asn Gln Trp Pro Cys Arg Leu Ser Trp Ala Leu Gln 
            660                 665                 670         


Cys Leu Glu Asp Arg Gln Gln Thr Gly Gly Ala Pro Glu Gly Arg Ala 
        675                 680                 685             


Arg Leu Trp Asp Val Phe Arg Asp Asn Ser Arg Glu Leu His Thr Met 
    690                 695                 700                 


Thr Lys Ala Leu Gln Asn Val Leu Asp Leu Asp Gly Asp Pro Glu Leu 
705                 710                 715                 720 


Phe Glu Arg Phe Leu Gly Ala Asp Phe Pro Phe Thr Val Ala Glu Ala 
                725                 730                 735     


Gln Ser Leu Leu Arg Cys Thr Val Asn Leu Asp His Ser Ile Arg Arg 
            740                 745                 750         


Arg Met Gly Leu Ile Arg Ala Val Ser Ala Leu Lys Pro Pro Ser Pro 
        755                 760                 765             


Pro Lys Ser Pro Thr Arg Asp Thr Pro His Ala Ala His Arg Ala Asn 
    770                 775                 780                 


Ser Ala Ser Arg Ala Pro Pro Ser Gly Arg Ala Ser Gly Gln Ala Gly 
785                 790                 795                 800 


Glu Gly His His Thr Gly Asp Leu Ala His Arg Gly Lys Leu Trp Pro 
                805                 810                 815     


Val Ala Cys Ala Leu Phe Arg Pro Gly Gln Ser Ser Pro Gly Gly Pro 
            820                 825                 830         


<210>  1470
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  1470

Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys 
    130                 135                 140                 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp 
145                 150                 155                 160 


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
                165                 170                 175     


Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu 
            180                 185                 190         


Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys 
        195                 200                 205             


Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro 
    210                 215                 220                 


Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu 
225                 230                 235                 240 


Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr Val Thr 
                245                 250                 255     


Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met 
            260                 265                 270         


Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu 
        275                 280                 285             


Pro Glu Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr 
    290                 295                 300                 


His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile 
305                 310                 315                 320 


Ile Glu Pro Gly Glu Glu Gly Pro Thr Ala Gly Ser Val Gly Gly Ser 
                325                 330                 335     


Gly Leu Gly Thr Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly Leu Gly 
            340                 345                 350         


Thr Ala Ala Leu Leu Ile Gly Val Ile Leu Trp Gln Arg Arg Gln Arg 
        355                 360                 365             


Arg Gly Glu Glu Arg Lys Ala Pro Glu Asn Gln Glu Glu Glu Glu Glu 
    370                 375                 380                 


Arg Ala Glu Leu Asn Gln Ser Glu Glu Pro Glu Ala Gly Glu Ser Ser 
385                 390                 395                 400 


Thr Gly Gly Pro 
                


<210>  1471
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  1471

Met Arg Ala Ala Pro Leu Leu Leu Ala Arg Ala Ala Ser Leu Ser Leu 
1               5                   10                  15      


Gly Phe Leu Phe Leu Leu Phe Phe Trp Leu Asp Arg Ser Val Leu Ala 
            20                  25                  30          


Lys Glu Leu Lys Phe Val Thr Leu Val Phe Arg His Gly Asp Arg Ser 
        35                  40                  45              


Pro Ile Asp Thr Phe Pro Thr Asp Pro Ile Lys Glu Ser Ser Trp Pro 
    50                  55                  60                  


Gln Gly Phe Gly Gln Leu Thr Gln Leu Gly Met Glu Gln His Tyr Glu 
65                  70                  75                  80  


Leu Gly Glu Tyr Ile Arg Lys Arg Tyr Arg Lys Phe Leu Asn Glu Ser 
                85                  90                  95      


Tyr Lys His Glu Gln Val Tyr Ile Arg Ser Thr Asp Val Asp Arg Thr 
            100                 105                 110         


Leu Met Ser Ala Met Thr Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly 
        115                 120                 125             


Val Ser Ile Trp Asn Pro Ile Leu Leu Trp Gln Pro Ile Pro Val His 
    130                 135                 140                 


Thr Val Pro Leu Ser Glu Asp Gln Leu Leu Tyr Leu Pro Phe Arg Asn 
145                 150                 155                 160 


Cys Pro Arg Phe Gln Glu Leu Glu Ser Glu Thr Leu Lys Ser Glu Glu 
                165                 170                 175     


Phe Gln Lys Arg Leu His Pro Tyr Lys Asp Phe Ile Ala Thr Leu Gly 
            180                 185                 190         


Lys Leu Ser Gly Leu His Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys 
        195                 200                 205             


Val Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Thr Leu Pro 
    210                 215                 220                 


Ser Trp Ala Thr Glu Asp Thr Met Thr Lys Leu Arg Glu Leu Ser Glu 
225                 230                 235                 240 


Leu Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser 
                245                 250                 255     


Arg Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Asn His Met Lys 
            260                 265                 270         


Arg Ala Thr Gln Ile Pro Ser Tyr Lys Lys Leu Ile Met Tyr Ser Ala 
        275                 280                 285             


His Asp Thr Thr Val Ser Gly Leu Gln Met Ala Leu Asp Val Tyr Asn 
    290                 295                 300                 


Gly Leu Leu Pro Pro Tyr Ala Ser Cys His Leu Thr Glu Leu Tyr Phe 
305                 310                 315                 320 


Glu Lys Gly Glu Tyr Phe Val Glu Met Tyr Tyr Arg Asn Glu Thr Gln 
                325                 330                 335     


His Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys Ser Pro Ser Cys Pro 
            340                 345                 350         


Leu Glu Arg Phe Ala Glu Leu Val Gly Pro Val Ile Pro Gln Asp Trp 
        355                 360                 365             


Ser Thr Glu Cys Met Thr Thr Asn Ser His Gln Val Leu Lys Val Ile 
    370                 375                 380                 


Phe Ala Val Ala Phe Cys Leu Ile Ser Ala Val Leu Met Val Leu Leu 
385                 390                 395                 400 


Phe Ile His Ile Arg Arg Gly Leu Cys Trp Gln Arg Glu Ser Tyr Gly 
                405                 410                 415     


Asn Ile 
        


<210>  1472
<211>  977
<212>  PRT
<213>  Homo sapiens

<400>  1472

Met Thr Ala Arg Glu His Ser Pro Arg His Gly Ala Arg Ala Arg Ala 
1               5                   10                  15      


Met Gln Arg Ala Ser Thr Ile Asp Val Ala Ala Asp Met Leu Gly Leu 
            20                  25                  30          


Ser Leu Ala Gly Asn Ile Gln Asp Pro Asp Glu Pro Ile Leu Glu Phe 
        35                  40                  45              


Ser Leu Ala Cys Ser Glu Leu His Thr Pro Ser Leu Asp Arg Lys Pro 
    50                  55                  60                  


Asn Ser Phe Val Ala Val Ser Val Thr Thr Pro Pro Gln Ala Phe Trp 
65                  70                  75                  80  


Thr Lys His Ala Gln Thr Glu Ile Ile Glu Gly Thr Asn Asn Pro Ile 
                85                  90                  95      


Phe Leu Ser Ser Ile Ala Phe Phe Gln Asp Ser Leu Ile Asn Gln Met 
            100                 105                 110         


Thr Gln Val Lys Leu Ser Val Tyr Asp Val Lys Asp Arg Ser Gln Gly 
        115                 120                 125             


Thr Met Tyr Leu Leu Gly Ser Gly Thr Phe Ile Val Lys Asp Leu Leu 
    130                 135                 140                 


Gln Asp Arg His His Arg Leu His Leu Thr Leu Arg Ser Ala Glu Ser 
145                 150                 155                 160 


Asp Arg Val Gly Asn Ile Thr Val Ile Gly Trp Gln Met Glu Glu Lys 
                165                 170                 175     


Ser Asp Gln Arg Pro Pro Val Thr Arg Ser Val Asp Thr Val Asn Gly 
            180                 185                 190         


Arg Met Val Leu Pro Val Asp Glu Ser Leu Thr Glu Ala Leu Gly Ile 
        195                 200                 205             


Arg Ser Lys Tyr Ala Ser Leu Arg Lys Asp Thr Leu Leu Lys Ser Val 
    210                 215                 220                 


Phe Gly Gly Ala Ile Cys Arg Met Tyr Arg Phe Pro Thr Thr Asp Gly 
225                 230                 235                 240 


Asn His Leu Arg Ile Leu Glu Gln Met Ala Glu Ser Val Leu Ser Leu 
                245                 250                 255     


His Val Pro Arg Gln Phe Val Lys Leu Leu Leu Glu Glu Asp Ala Ala 
            260                 265                 270         


Arg Val Cys Glu Leu Glu Glu Leu Gly Glu Leu Ser Pro Cys Trp Glu 
        275                 280                 285             


Ser Leu Arg Arg Gln Ile Val Thr Gln Tyr Gln Thr Ile Ile Leu Thr 
    290                 295                 300                 


Tyr Gln Glu Asn Leu Thr Asp Leu His Gln Tyr Arg Gly Pro Ser Phe 
305                 310                 315                 320 


Lys Ala Ser Ser Leu Lys Ala Asp Lys Lys Leu Glu Phe Val Pro Thr 
                325                 330                 335     


Asn Leu His Ile Gln Arg Met Arg Val Gln Asp Asp Gly Gly Ser Asp 
            340                 345                 350         


Gln Asn Tyr Asp Ile Val Thr Ile Gly Ala Pro Ala Ala His Cys Gln 
        355                 360                 365             


Gly Phe Lys Ser Gly Gly Leu Arg Lys Lys Leu His Lys Phe Glu Glu 
    370                 375                 380                 


Thr Lys Lys His Phe Glu Glu Cys Cys Thr Ser Ser Gly Cys Gln Ser 
385                 390                 395                 400 


Ile Ile Tyr Ile Pro Gln Asp Val Val Arg Ala Lys Glu Ile Ile Ala 
                405                 410                 415     


Gln Ile Asn Thr Leu Lys Thr Gln Val Ser Tyr Tyr Ala Glu Arg Leu 
            420                 425                 430         


Ser Arg Ala Ala Lys Asp Arg Ser Ala Thr Gly Leu Glu Arg Thr Leu 
        435                 440                 445             


Ala Ile Leu Ala Asp Lys Thr Arg Gln Leu Val Thr Val Cys Asp Cys 
    450                 455                 460                 


Lys Leu Leu Ala Asn Ser Ile His Gly Leu Asn Ala Ala Arg Pro Asp 
465                 470                 475                 480 


Tyr Ile Ala Ser Lys Ala Ser Pro Thr Ser Thr Glu Glu Glu Gln Val 
                485                 490                 495     


Met Leu Arg Asn Asp Gln Asp Thr Leu Met Ala Arg Trp Thr Gly Arg 
            500                 505                 510         


Asn Ser Arg Ser Ser Leu Gln Val Asp Trp His Glu Glu Glu Trp Glu 
        515                 520                 525             


Lys Val Trp Leu Asn Val Asp Lys Ser Leu Glu Cys Ile Ile Gln Arg 
    530                 535                 540                 


Val Asp Lys Leu Leu Gln Lys Glu Arg Leu His Gly Glu Gly Cys Glu 
545                 550                 555                 560 


Asp Val Phe Pro Cys Ala Gly Ser Cys Thr Ser Lys Lys Gly Asn Pro 
                565                 570                 575     


Asp Ser His Ala Tyr Trp Ile Arg Pro Glu Asp Pro Phe Cys Asp Val 
            580                 585                 590         


Pro Ser Ser Pro Cys Pro Ser Thr Met Pro Ser Thr Ala Cys His Pro 
        595                 600                 605             


His Leu Thr Thr His Cys Ser Pro Pro Pro Glu Glu Ser Ser Pro Gly 
    610                 615                 620                 


Glu Trp Ser Glu Ala Leu Tyr Pro Leu Leu Thr Thr Leu Thr Asp Cys 
625                 630                 635                 640 


Val Ala Met Met Ser Asp Lys Ala Lys Lys Ala Met Val Phe Leu Leu 
                645                 650                 655     


Met Gln Asp Ser Ala Pro Thr Ile Ala Thr Tyr Leu Ser Leu Gln Tyr 
            660                 665                 670         


Arg Arg Asp Val Val Phe Cys Gln Thr Leu Thr Ala Leu Ile Cys Gly 
        675                 680                 685             


Phe Ile Ile Lys Leu Arg Asn Cys Leu His Asp Asp Gly Phe Leu Arg 
    690                 695                 700                 


Gln Leu Tyr Thr Ile Gly Leu Leu Ala Gln Phe Glu Ser Leu Leu Ser 
705                 710                 715                 720 


Thr Tyr Gly Glu Glu Leu Ala Met Leu Glu Asp Met Ser Leu Gly Ile 
                725                 730                 735     


Met Asp Leu Arg Asn Val Thr Phe Lys Val Thr Gln Ala Thr Ser Ser 
            740                 745                 750         


Ala Ser Ala Asp Met Leu Pro Val Ile Thr Gly Asn Arg Asp Gly Phe 
        755                 760                 765             


Asn Val Arg Val Pro Leu Pro Gly Pro Leu Phe Asp Ala Leu Pro Arg 
    770                 775                 780                 


Glu Ile Gln Ser Gly Met Leu Leu Arg Val Gln Pro Val Leu Phe Asn 
785                 790                 795                 800 


Val Gly Ile Asn Glu Gln Gln Thr Leu Ala Glu Arg Phe Gly Asp Thr 
                805                 810                 815     


Ser Leu Gln Glu Val Ile Asn Val Glu Ser Leu Val Arg Leu Asn Ser 
            820                 825                 830         


Tyr Phe Glu Gln Phe Lys Glu Val Leu Pro Glu Asp Cys Leu Pro Arg 
        835                 840                 845             


Ser Arg Ser Gln Thr Cys Leu Pro Glu Leu Leu Arg Phe Leu Gly Gln 
    850                 855                 860                 


Asn Val His Ala Arg Lys Asn Lys Asn Val Asp Ile Leu Trp Gln Ala 
865                 870                 875                 880 


Ala Glu Ile Cys Arg Arg Leu Asn Gly Val Arg Phe Thr Ser Cys Lys 
                885                 890                 895     


Ser Ala Lys Asp Arg Thr Ala Met Ser Val Thr Leu Glu Gln Cys Leu 
            900                 905                 910         


Ile Leu Gln His Glu His Gly Met Ala Pro Gln Val Phe Thr Gln Ala 
        915                 920                 925             


Leu Glu Cys Met Arg Ser Glu Gly Cys Arg Arg Glu Asn Thr Met Lys 
    930                 935                 940                 


Asn Val Gly Ser Arg Lys Tyr Ala Phe Asn Ser Leu Gln Leu Lys Ala 
945                 950                 955                 960 


Phe Pro Lys His Tyr Arg Pro Pro Glu Gly Thr Tyr Gly Lys Val Glu 
                965                 970                 975     


Thr 
    


<210>  1473
<211>  972
<212>  PRT
<213>  Homo sapiens

<400>  1473

Met Thr Ala Arg Glu His Ser Pro Arg His Gly Ala Arg Ala Arg Ala 
1               5                   10                  15      


Met Gln Arg Ala Ser Thr Ile Asp Val Ala Ala Asp Met Leu Gly Leu 
            20                  25                  30          


Ser Leu Ala Gly Asn Ile Gln Asp Pro Asp Glu Pro Ile Leu Glu Phe 
        35                  40                  45              


Ser Leu Ala Cys Ser Glu Leu His Thr Pro Ser Leu Asp Arg Lys Pro 
    50                  55                  60                  


Asn Ser Phe Val Ala Val Ser Val Thr Thr Pro Pro Gln Ala Phe Trp 
65                  70                  75                  80  


Thr Lys His Ala Gln Thr Glu Ile Ile Glu Gly Thr Asn Asn Pro Ile 
                85                  90                  95      


Phe Leu Ser Ser Ile Ala Phe Phe Gln Asp Ser Leu Ile Asn Gln Met 
            100                 105                 110         


Thr Gln Val Lys Leu Ser Val Tyr Asp Val Lys Asp Arg Ser Gln Gly 
        115                 120                 125             


Thr Met Tyr Leu Leu Gly Ser Gly Thr Phe Ile Val Lys Asp Leu Leu 
    130                 135                 140                 


Gln Asp Arg His His Arg Leu His Leu Thr Leu Arg Ser Ala Glu Ser 
145                 150                 155                 160 


Asp Arg Val Gly Asn Ile Thr Val Ile Gly Trp Gln Met Glu Glu Lys 
                165                 170                 175     


Ser Asp Gln Arg Pro Pro Val Thr Arg Ser Val Asp Thr Val Asn Gly 
            180                 185                 190         


Arg Met Val Leu Pro Val Asp Glu Ser Leu Thr Glu Ala Leu Gly Ile 
        195                 200                 205             


Arg Ser Lys Tyr Ala Ser Leu Arg Lys Asp Thr Leu Leu Lys Ser Val 
    210                 215                 220                 


Phe Gly Gly Ala Ile Cys Arg Met Tyr Arg Phe Pro Thr Thr Asp Gly 
225                 230                 235                 240 


Asn His Leu Arg Ile Leu Glu Gln Met Ala Glu Ser Val Leu Ser Leu 
                245                 250                 255     


His Val Pro Arg Gln Phe Val Lys Leu Leu Leu Glu Glu Asp Ala Ala 
            260                 265                 270         


Arg Val Cys Glu Leu Glu Glu Leu Gly Glu Leu Ser Pro Cys Trp Glu 
        275                 280                 285             


Ser Leu Arg Arg Gln Ile Val Thr Gln Tyr Gln Thr Ile Ile Leu Thr 
    290                 295                 300                 


Tyr Gln Glu Asn Leu Thr Asp Leu His Gln Tyr Arg Gly Pro Ser Phe 
305                 310                 315                 320 


Lys Ala Ser Ser Leu Lys Ala Asp Lys Lys Leu Glu Phe Val Pro Thr 
                325                 330                 335     


Asn Leu His Ile Gln Arg Met Arg Val Gln Asp Asp Gly Gly Ser Asp 
            340                 345                 350         


Gln Asn Tyr Asp Ile Val Thr Ile Gly Ala Pro Ala Ala His Cys Gln 
        355                 360                 365             


Gly Phe Lys Ser Gly Gly Leu Arg Lys Lys Leu His Lys Phe Glu Glu 
    370                 375                 380                 


Thr Lys Lys His Thr Ser Ser Gly Cys Gln Ser Ile Ile Tyr Ile Pro 
385                 390                 395                 400 


Gln Asp Val Val Arg Ala Lys Glu Ile Ile Ala Gln Ile Asn Thr Leu 
                405                 410                 415     


Lys Thr Gln Val Ser Tyr Tyr Ala Glu Arg Leu Ser Arg Ala Ala Lys 
            420                 425                 430         


Asp Arg Ser Ala Thr Gly Leu Glu Arg Thr Leu Ala Ile Leu Ala Asp 
        435                 440                 445             


Lys Thr Arg Gln Leu Val Thr Val Cys Asp Cys Lys Leu Leu Ala Asn 
    450                 455                 460                 


Ser Ile His Gly Leu Asn Ala Ala Arg Pro Asp Tyr Ile Ala Ser Lys 
465                 470                 475                 480 


Ala Ser Pro Thr Ser Thr Glu Glu Glu Gln Val Met Leu Arg Asn Asp 
                485                 490                 495     


Gln Asp Thr Leu Met Ala Arg Trp Thr Gly Arg Asn Ser Arg Ser Ser 
            500                 505                 510         


Leu Gln Val Asp Trp His Glu Glu Glu Trp Glu Lys Val Trp Leu Asn 
        515                 520                 525             


Val Asp Lys Ser Leu Glu Cys Ile Ile Gln Arg Val Asp Lys Leu Leu 
    530                 535                 540                 


Gln Lys Glu Arg Leu His Gly Glu Gly Cys Glu Asp Val Phe Pro Cys 
545                 550                 555                 560 


Ala Gly Ser Cys Thr Ser Lys Lys Gly Asn Pro Asp Ser His Ala Tyr 
                565                 570                 575     


Trp Ile Arg Pro Glu Asp Pro Phe Cys Asp Val Pro Ser Ser Pro Cys 
            580                 585                 590         


Pro Ser Thr Met Pro Ser Thr Ala Cys His Pro His Leu Thr Thr His 
        595                 600                 605             


Cys Ser Pro Pro Pro Glu Glu Ser Ser Pro Gly Glu Trp Ser Glu Ala 
    610                 615                 620                 


Leu Tyr Pro Leu Leu Thr Thr Leu Thr Asp Cys Val Ala Met Met Ser 
625                 630                 635                 640 


Asp Lys Ala Lys Lys Ala Met Val Phe Leu Leu Met Gln Asp Ser Ala 
                645                 650                 655     


Pro Thr Ile Ala Thr Tyr Leu Ser Leu Gln Tyr Arg Arg Asp Val Val 
            660                 665                 670         


Phe Cys Gln Thr Leu Thr Ala Leu Ile Cys Gly Phe Ile Ile Lys Leu 
        675                 680                 685             


Arg Asn Cys Leu His Asp Asp Gly Phe Leu Arg Gln Leu Tyr Thr Ile 
    690                 695                 700                 


Gly Leu Leu Ala Gln Phe Glu Ser Leu Leu Ser Thr Tyr Gly Glu Glu 
705                 710                 715                 720 


Leu Ala Met Leu Glu Asp Met Ser Leu Gly Ile Met Asp Leu Arg Asn 
                725                 730                 735     


Val Thr Phe Lys Val Thr Gln Ala Thr Ser Ser Ala Ser Ala Asp Met 
            740                 745                 750         


Leu Pro Val Ile Thr Gly Asn Arg Asp Gly Phe Asn Val Arg Val Pro 
        755                 760                 765             


Leu Pro Gly Pro Leu Phe Asp Ala Leu Pro Arg Glu Ile Gln Ser Gly 
    770                 775                 780                 


Met Leu Leu Arg Val Gln Pro Val Leu Phe Asn Val Gly Ile Asn Glu 
785                 790                 795                 800 


Gln Gln Thr Leu Ala Glu Arg Phe Gly Asp Thr Ser Leu Gln Glu Val 
                805                 810                 815     


Ile Asn Val Glu Ser Leu Val Arg Leu Asn Ser Tyr Phe Glu Gln Phe 
            820                 825                 830         


Lys Glu Val Leu Pro Glu Asp Cys Leu Pro Arg Ser Arg Ser Gln Thr 
        835                 840                 845             


Cys Leu Pro Glu Leu Leu Arg Phe Leu Gly Gln Asn Val His Ala Arg 
    850                 855                 860                 


Lys Asn Lys Asn Val Asp Ile Leu Trp Gln Ala Ala Glu Ile Cys Arg 
865                 870                 875                 880 


Arg Leu Asn Gly Val Arg Phe Thr Ser Cys Lys Ser Ala Lys Asp Arg 
                885                 890                 895     


Thr Ala Met Ser Val Thr Leu Glu Gln Cys Leu Ile Leu Gln His Glu 
            900                 905                 910         


His Gly Met Ala Pro Gln Val Phe Thr Gln Ala Leu Glu Cys Met Arg 
        915                 920                 925             


Ser Glu Gly Cys Arg Arg Glu Asn Thr Met Lys Asn Val Gly Ser Arg 
    930                 935                 940                 


Lys Tyr Ala Phe Asn Ser Leu Gln Leu Lys Ala Phe Pro Lys His Tyr 
945                 950                 955                 960 


Arg Pro Pro Glu Gly Thr Tyr Gly Lys Val Glu Thr 
                965                 970         


<210>  1474
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  1474

Met Gly Lys Ser Leu Ser His Leu Pro Leu His Ser Ser Lys Glu Asp 
1               5                   10                  15      


Ala Tyr Asp Gly Val Thr Ser Glu Asn Met Arg Asn Gly Leu Val Asn 
            20                  25                  30          


Ser Glu Val His Asn Glu Asp Gly Arg Asn Gly Asp Val Ser Gln Phe 
        35                  40                  45              


Pro Tyr Val Glu Phe Thr Gly Arg Asp Ser Val Thr Cys Pro Thr Cys 
    50                  55                  60                  


Gln Gly Thr Gly Arg Ile Pro Arg Gly Gln Glu Asn Gln Leu Val Ala 
65                  70                  75                  80  


Leu Ile Pro Tyr Ser Asp Gln Arg Leu Arg Pro Arg Arg Thr Lys Leu 
                85                  90                  95      


Tyr Val Met Ala Ser Val Phe Val Cys Leu Leu Leu Ser Gly Leu Ala 
            100                 105                 110         


Val Phe Phe Leu Phe Pro Arg Ser Ile Asp Val Lys Tyr Ile Gly Val 
        115                 120                 125             


Lys Ser Ala Tyr Val Ser Tyr Asp Val Gln Lys Arg Thr Ile Tyr Leu 
    130                 135                 140                 


Asn Ile Thr Asn Thr Leu Asn Ile Thr Asn Asn Asn Tyr Tyr Ser Val 
145                 150                 155                 160 


Glu Val Glu Asn Ile Thr Ala Gln Val Gln Phe Ser Lys Thr Val Ile 
                165                 170                 175     


Gly Lys Ala Arg Leu Asn Asn Ile Thr Ile Ile Gly Pro Leu Asp Met 
            180                 185                 190         


Lys Gln Ile Asp Tyr Thr Val Pro Thr Val Ile Ala Glu Glu Met Ser 
        195                 200                 205             


Tyr Met Tyr Asp Phe Cys Thr Leu Ile Ser Ile Lys Val His Asn Ile 
    210                 215                 220                 


Val Leu Met Met Gln Val Thr Val Thr Thr Thr Tyr Phe Gly His Ser 
225                 230                 235                 240 


Glu Gln Ile Ser Gln Glu Arg Tyr Gln Tyr Val Asp Cys Gly Arg Asn 
                245                 250                 255     


Thr Thr Tyr Gln Leu Gly Gln Ser Glu Tyr Leu Asn Val Leu Gln Pro 
            260                 265                 270         


Gln Gln 
        


<210>  1475
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  1475

Met Ser Ser Asp Phe Pro His Tyr Asn Phe Arg Met Pro Asn Ile Gly 
1               5                   10                  15      


Phe Gln Asn Leu Pro Leu Asn Ile Tyr Ile Val Val Phe Gly Thr Ala 
            20                  25                  30          


Ile Phe Val Phe Ile Leu Ser Leu Leu Phe Cys Cys Tyr Leu Ile Arg 
        35                  40                  45              


Leu Arg His Gln Ala His Lys Glu Phe Tyr Ala Tyr Lys Gln Val Ile 
    50                  55                  60                  


Leu Lys Glu Lys Val Lys Glu Leu Asn Leu His Glu Leu Cys Ala Val 
65                  70                  75                  80  


Cys Leu Glu Asp Phe Lys Pro Arg Asp Glu Leu Gly Ile Cys Pro Cys 
                85                  90                  95      


Lys His Ala Phe His Arg Lys Cys Leu Ile Lys Trp Leu Glu Val Arg 
            100                 105                 110         


Lys Val Cys Pro Leu Cys Asn Met Pro Val Leu Gln Leu Ala Gln Leu 
        115                 120                 125             


His Ser Lys Gln Asp Arg Gly Pro Pro Gln Gly Pro Leu Pro Gly Ala 
    130                 135                 140                 


Glu Asn Ile Val 
145             


<210>  1476
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  1476

Met Leu Asn Lys Ser Gly Glu Ser Arg Tyr Pro Ala Leu Phe Pro Val 
1               5                   10                  15      


Leu Gly Gly Ser Ser Met Ser Ser Asp Phe Pro His Tyr Asn Phe Arg 
            20                  25                  30          


Met Pro Asn Ile Gly Phe Gln Asn Leu Pro Leu Asn Ile Tyr Ile Val 
        35                  40                  45              


Val Phe Gly Thr Ala Ile Phe Val Phe Ile Leu Ser Leu Leu Phe Cys 
    50                  55                  60                  


Cys Tyr Leu Ile Arg Leu Arg His Gln Ala His Lys Glu Phe Tyr Ala 
65                  70                  75                  80  


Tyr Lys Gln Val Ile Leu Lys Glu Lys Val Lys Glu Leu Asn Leu His 
                85                  90                  95      


Glu Leu Cys Ala Val Cys Leu Glu Asp Phe Lys Pro Arg Asp Glu Leu 
            100                 105                 110         


Gly Ile Cys Pro Cys Lys His Ala Phe His Arg Lys Cys Leu Ile Lys 
        115                 120                 125             


Trp Leu Glu Val Arg Lys Val Cys Pro Leu Cys Asn Met Pro Val Leu 
    130                 135                 140                 


Gln Leu Ala Gln Leu His Ser Lys Gln Asp Arg Gly Pro Pro Gln Gly 
145                 150                 155                 160 


Pro Leu Pro Gly Ala Glu Asn Ile Val 
                165                 


<210>  1477
<211>  721
<212>  PRT
<213>  Homo sapiens

<400>  1477

Met Gly Asp Ala Glu Ser Cys Leu Leu Arg Gln Gln Thr Arg Glu Val 
1               5                   10                  15      


Arg Lys Lys Pro Leu Ile Asn Tyr Arg Phe Leu Arg Ala Ala Ala Asn 
            20                  25                  30          


Ala Glu Pro Arg Gly Pro Gln Ala Gln Arg Thr Ser Cys Ala Lys Arg 
        35                  40                  45              


Glu Cys Gly Ala Phe Thr Gln Arg Val Arg Glu Arg Ala Gly Arg Gln 
    50                  55                  60                  


Pro Pro Ala Gly Gly Thr Arg His Ser Arg Ala Glu Arg Gly Arg Arg 
65                  70                  75                  80  


Arg Ser His Pro Arg Ser Arg Thr Arg Thr Thr Ala Leu Leu Arg Ser 
                85                  90                  95      


Ser Gln Thr Lys Glu Met Ala Thr Lys Glu Lys Leu Gln Cys Leu Lys 
            100                 105                 110         


Asp Phe His Lys Asp Ile Leu Lys Pro Ser Pro Gly Lys Ser Pro Gly 
        115                 120                 125             


Thr Arg Pro Glu Asp Glu Ala Glu Gly Lys Pro Pro Gln Arg Glu Lys 
    130                 135                 140                 


Trp Ser Ser Lys Ile Asp Phe Val Leu Ser Val Ala Gly Gly Phe Val 
145                 150                 155                 160 


Gly Leu Gly Asn Val Trp Arg Phe Pro Tyr Leu Cys Tyr Lys Asn Gly 
                165                 170                 175     


Gly Gly Ala Phe Leu Ile Pro Tyr Phe Ile Phe Leu Phe Gly Ser Gly 
            180                 185                 190         


Leu Pro Val Phe Phe Leu Glu Ile Ile Ile Gly Gln Tyr Thr Ser Glu 
        195                 200                 205             


Gly Gly Ile Thr Cys Trp Glu Lys Ile Cys Pro Leu Phe Ser Gly Ile 
    210                 215                 220                 


Gly Tyr Ala Ser Val Val Ile Val Ser Leu Leu Asn Val Tyr Tyr Ile 
225                 230                 235                 240 


Val Ile Leu Ala Trp Ala Thr Tyr Tyr Leu Phe Gln Ser Phe Gln Lys 
                245                 250                 255     


Glu Leu Pro Trp Ala His Cys Asn His Ser Trp Asn Thr Pro His Cys 
            260                 265                 270         


Met Glu Asp Thr Met Arg Lys Asn Lys Ser Val Trp Ile Thr Ile Ser 
        275                 280                 285             


Ser Thr Asn Phe Thr Ser Pro Val Ile Glu Phe Trp Glu Arg Asn Val 
    290                 295                 300                 


Leu Ser Leu Ser Pro Gly Ile Asp His Pro Gly Ser Leu Lys Trp Asp 
305                 310                 315                 320 


Leu Ala Leu Cys Leu Leu Leu Val Trp Leu Val Cys Phe Phe Cys Ile 
                325                 330                 335     


Trp Lys Gly Val Arg Ser Thr Gly Lys Val Val Tyr Phe Thr Ala Thr 
            340                 345                 350         


Phe Pro Phe Ala Met Leu Leu Val Leu Leu Val Arg Gly Leu Thr Leu 
        355                 360                 365             


Pro Gly Ala Gly Ala Gly Ile Lys Phe Tyr Leu Tyr Pro Asp Ile Thr 
    370                 375                 380                 


Arg Leu Glu Asp Pro Gln Val Trp Ile Asp Ala Gly Thr Gln Ile Phe 
385                 390                 395                 400 


Phe Ser Tyr Ala Ile Cys Leu Gly Ala Met Thr Ser Leu Gly Ser Tyr 
                405                 410                 415     


Asn Lys Tyr Lys Tyr Asn Ser Tyr Arg Asp Cys Met Leu Leu Gly Cys 
            420                 425                 430         


Leu Asn Ser Gly Thr Ser Phe Val Ser Gly Phe Ala Ile Phe Ser Ile 
        435                 440                 445             


Leu Gly Phe Met Ala Gln Glu Gln Gly Val Asp Ile Ala Asp Val Ala 
    450                 455                 460                 


Glu Ser Gly Pro Gly Leu Ala Phe Ile Ala Tyr Pro Lys Ala Val Thr 
465                 470                 475                 480 


Met Met Pro Leu Pro Thr Phe Trp Ser Ile Leu Phe Phe Ile Met Leu 
                485                 490                 495     


Leu Leu Leu Gly Leu Asp Ser Gln Phe Val Glu Val Glu Gly Gln Ile 
            500                 505                 510         


Thr Ser Leu Val Asp Leu Tyr Pro Ser Phe Leu Arg Lys Gly Tyr Arg 
        515                 520                 525             


Arg Glu Ile Phe Ile Ala Phe Val Cys Ser Ile Ser Tyr Leu Leu Gly 
    530                 535                 540                 


Leu Thr Met Val Thr Glu Gly Gly Met Tyr Val Phe Gln Leu Phe Asp 
545                 550                 555                 560 


Tyr Tyr Ala Ala Ser Gly Val Cys Leu Leu Trp Val Ala Phe Phe Glu 
                565                 570                 575     


Cys Phe Val Ile Ala Trp Ile Tyr Gly Gly Asp Asn Leu Tyr Asp Gly 
            580                 585                 590         


Ile Glu Asp Met Ile Gly Tyr Arg Pro Gly Pro Trp Met Lys Tyr Ser 
        595                 600                 605             


Trp Ala Val Ile Thr Pro Val Leu Cys Val Gly Cys Phe Ile Phe Ser 
    610                 615                 620                 


Leu Val Lys Tyr Val Pro Leu Thr Tyr Asn Lys Thr Tyr Val Tyr Pro 
625                 630                 635                 640 


Asn Trp Ala Ile Gly Leu Gly Trp Ser Leu Ala Leu Ser Ser Met Leu 
                645                 650                 655     


Cys Val Pro Leu Val Ile Val Ile Arg Leu Cys Gln Thr Glu Gly Pro 
            660                 665                 670         


Phe Leu Val Arg Val Lys Tyr Leu Leu Thr Pro Arg Glu Pro Asn Arg 
        675                 680                 685             


Trp Ala Val Glu Arg Glu Gly Ala Thr Pro Tyr Asn Ser Arg Thr Val 
    690                 695                 700                 


Met Asn Gly Ala Leu Val Lys Pro Thr His Ile Ile Val Glu Thr Met 
705                 710                 715                 720 


Met 
    


<210>  1478
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  1478

Met Ala Thr Lys Glu Lys Leu Gln Cys Leu Lys Asp Phe His Lys Asp 
1               5                   10                  15      


Ile Leu Lys Pro Ser Pro Gly Lys Ser Pro Gly Thr Arg Pro Glu Asp 
            20                  25                  30          


Glu Ala Glu Gly Lys Pro Pro Gln Arg Glu Lys Trp Ser Ser Lys Ile 
        35                  40                  45              


Asp Phe Val Leu Ser Val Ala Gly Gly Phe Val Gly Leu Gly Asn Val 
    50                  55                  60                  


Trp Arg Phe Pro Tyr Leu Cys Tyr Lys Asn Gly Gly Gly Ala Phe Leu 
65                  70                  75                  80  


Ile Pro Tyr Phe Ile Phe Leu Phe Gly Ser Gly Leu Pro Val Phe Phe 
                85                  90                  95      


Leu Glu Ile Ile Ile Gly Gln Tyr Thr Ser Glu Gly Gly Ile Thr Cys 
            100                 105                 110         


Trp Glu Lys Ile Cys Pro Leu Phe Ser Gly Ile Gly Tyr Ala Ser Val 
        115                 120                 125             


Val Ile Val Ser Leu Leu Asn Val Tyr Tyr Ile Val Ile Leu Ala Trp 
    130                 135                 140                 


Ala Thr Tyr Tyr Leu Phe Gln Ser Phe Gln Lys Glu Leu Pro Trp Ala 
145                 150                 155                 160 


His Cys Asn His Ser Trp Asn Thr Pro His Cys Met Glu Asp Thr Met 
                165                 170                 175     


Arg Lys Asn Lys Ser Val Trp Ile Thr Ile Ser Ser Thr Asn Phe Thr 
            180                 185                 190         


Ser Pro Val Ile Glu Phe Trp Glu 
        195                 200 


<210>  1479
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  1479

Met Asp Phe Leu Val Leu Phe Leu Phe Tyr Leu Ala Ser Val Leu Met 
1               5                   10                  15      


Gly Leu Val Leu Ile Cys Val Cys Ser Lys Thr His Ser Leu Lys Gly 
            20                  25                  30          


Leu Ala Arg Gly Gly Ala Gln Ile Phe Ser Cys Ile Ile Pro Glu Cys 
        35                  40                  45              


Leu Gln Arg Ala Val His Gly Leu Leu His Tyr Leu Phe His Thr Arg 
    50                  55                  60                  


Asn His Thr Phe Ile Val Leu His Leu Val Leu Gln Gly Met Val Tyr 
65                  70                  75                  80  


Thr Glu Tyr Thr Trp Glu Val Phe Gly Tyr Cys Gln Glu Leu Glu Leu 
                85                  90                  95      


Ser Leu His Tyr Leu Leu Leu Pro Tyr Leu Leu Leu Gly Val Asn Leu 
            100                 105                 110         


Phe Phe Phe Thr Leu Thr Cys Gly Thr Asn Pro Gly Ile Ile Thr Lys 
        115                 120                 125             


Ala Asn Glu Leu Leu Phe Leu His Val Tyr Glu Phe Asp Glu Val Met 
    130                 135                 140                 


Phe Pro Lys Asn Val Arg Cys Ser Thr Cys Asp Leu Arg Lys Pro Ala 
145                 150                 155                 160 


Arg Ser Lys His Cys Ser Val Cys Asn Trp Cys Val His Arg Phe Asp 
                165                 170                 175     


His His Cys Val Trp Val Asn Asn Cys Ile Gly Ala Trp Asn Ile Arg 
            180                 185                 190         


Tyr Phe Leu Ile Tyr Val Leu Thr Leu Thr Ala Ser Ala Ala Thr Val 
        195                 200                 205             


Ala Ile Val Ser Thr Thr Phe Leu Val His Leu Val Val Met Ser Asp 
    210                 215                 220                 


Leu Tyr Gln Glu Thr Tyr Ile Asp Asp Leu Gly His Leu His Val Met 
225                 230                 235                 240 


Asp Thr Val Phe Leu Ile Gln Tyr Leu Phe Leu Thr Phe Pro Arg Ile 
                245                 250                 255     


Val Phe Met Leu Gly Phe Val Val Val Leu Ser Phe Leu Leu Gly Gly 
            260                 265                 270         


Tyr Leu Leu Phe Val Leu Tyr Leu Ala Ala Thr Asn Gln Thr Thr Asn 
        275                 280                 285             


Glu Trp Tyr Arg Gly Asp Trp Ala Trp Cys Gln Arg Cys Pro Leu Val 
    290                 295                 300                 


Ala Trp Pro Pro Ser Ala Glu Pro Gln Val His Arg Asn Ile His Ser 
305                 310                 315                 320 


His Gly Leu Arg Ser Asn Leu Gln Glu Ile Phe Leu Pro Ala Phe Pro 
                325                 330                 335     


Cys His Glu Arg Lys Lys Gln Glu 
            340                 


<210>  1480
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  1480

Met Asp Phe Leu Val Leu Phe Leu Phe Tyr Leu Ala Ser Val Leu Met 
1               5                   10                  15      


Gly Leu Val Leu Ile Cys Val Cys Ser Lys Thr His Ser Leu Lys Gly 
            20                  25                  30          


Leu Ala Arg Gly Gly Ala Gln Ile Phe Ser Cys Ile Ile Pro Glu Cys 
        35                  40                  45              


Leu Gln Arg Ala Val His Gly Leu Leu His Tyr Leu Phe His Thr Arg 
    50                  55                  60                  


Asn His Thr Phe Ile Val Leu His Leu Val Leu Gln Gly Met Val Tyr 
65                  70                  75                  80  


Thr Glu Tyr Thr Trp Glu Val Phe Gly Tyr Cys Gln Glu Leu Glu Leu 
                85                  90                  95      


Ser Leu His Tyr Leu Leu Leu Pro Tyr Leu Leu Leu Gly Val Asn Leu 
            100                 105                 110         


Phe Phe Phe Thr Leu Thr Cys Gly Thr Asn Pro Gly Ile Ile Thr Lys 
        115                 120                 125             


Ala Asn Glu Leu Leu Phe Leu His Val Tyr Glu Phe Asp Glu Val Met 
    130                 135                 140                 


Phe Pro Lys Asn Val Arg Cys Ser Thr Cys Asp Leu Arg Lys Pro Ala 
145                 150                 155                 160 


Arg Ser Lys His Cys Ser Val Cys Asn Trp Cys Val His Arg Phe Asp 
                165                 170                 175     


His His Cys Val Trp Val Asn Asn Cys Ile Gly Ala Trp Asn Ile Arg 
            180                 185                 190         


Tyr Phe Leu Ile Tyr Val Leu Thr Leu Thr Ala Ser Ala Ala Thr Val 
        195                 200                 205             


Ala Ile Val Ser Thr Thr Phe Leu Val His Leu Val Val Met Ser Asp 
    210                 215                 220                 


Leu Tyr Gln Glu Thr Tyr Ile Asp Asp Leu Gly His Leu His Val Met 
225                 230                 235                 240 


Asp Thr Val Phe Leu Ile Gln Tyr Leu Phe Leu Thr Phe Pro Arg Ile 
                245                 250                 255     


Val Phe Met Leu Gly Phe Val Val Val Leu Ser Phe Leu Leu Gly Gly 
            260                 265                 270         


Tyr Leu Leu Phe Val Leu Tyr Leu Ala Ala Thr Asn Gln Thr Thr Asn 
        275                 280                 285             


Glu Trp Tyr Arg Gly Asp Trp Ala Trp Cys Gln Arg Cys Pro Leu Val 
    290                 295                 300                 


Ala Trp Pro Pro Ser Ala Glu Pro Gln Val His Arg Asn Ile His Ser 
305                 310                 315                 320 


His Gly Leu Arg Ser Asn Leu Gln Glu Ile Phe Leu Pro Ala Phe Pro 
                325                 330                 335     


Cys His Glu Arg Lys Lys Gln Glu 
            340                 


<210>  1481
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  1481

Met Asp Phe Leu Val Leu Phe Leu Phe Tyr Leu Ala Ser Val Leu Met 
1               5                   10                  15      


Gly Leu Val Leu Ile Cys Val Cys Ser Lys Thr His Ser Leu Lys Gly 
            20                  25                  30          


Leu Ala Arg Gly Gly Ala Gln Ile Phe Ser Cys Ile Ile Pro Glu Cys 
        35                  40                  45              


Leu Gln Arg Ala Val His Gly Leu Leu His Tyr Leu Phe His Thr Arg 
    50                  55                  60                  


Asn His Thr Phe Ile Val Leu His Leu Val Leu Gln Gly Met Val Tyr 
65                  70                  75                  80  


Thr Glu Tyr Thr Trp Glu Val Phe Gly Tyr Cys Gln Glu Leu Glu Leu 
                85                  90                  95      


Ser Leu His Tyr Leu Leu Leu Pro Tyr Leu Leu Leu Gly Val Asn Leu 
            100                 105                 110         


Phe Phe Phe Thr Leu Thr Cys Gly Thr Asn Pro Gly Ile Ile Thr Lys 
        115                 120                 125             


Ala Asn Glu Leu Leu Phe Leu His Val Tyr Glu Phe Asp Glu Val Met 
    130                 135                 140                 


Phe Pro Lys Asn Val Arg Cys Ser Thr Cys Asp Leu Arg Lys Pro Ala 
145                 150                 155                 160 


Arg Ser Lys His Cys Ser Val Cys Asn Trp Cys Val His Arg Phe Asp 
                165                 170                 175     


His His Cys Val Trp Val Asn Asn Cys Ile Gly Ala Trp Asn Ile Arg 
            180                 185                 190         


Tyr Phe Leu Ile Tyr Val Leu Thr Leu Thr Ala Ser Ala Ala Thr Val 
        195                 200                 205             


Ala Ile Val Ser Thr Thr Phe Leu Val His Leu Val Val Met Ser Asp 
    210                 215                 220                 


Leu Tyr Gln Glu Thr Tyr Ile Asp Asp Leu Gly His Leu His Val Met 
225                 230                 235                 240 


Asp Thr Val Phe Leu Ile Gln Tyr Leu Phe Leu Thr Phe Pro Arg Ile 
                245                 250                 255     


Val Phe Met Leu Gly Phe Val Val Val Leu Ser Phe Leu Leu Gly Gly 
            260                 265                 270         


Tyr Leu Leu Phe Val Leu Tyr Leu Ala Ala Thr Asn Gln Thr Thr Asn 
        275                 280                 285             


Glu Trp Tyr Arg Gly Asp Trp Ala Trp Cys Gln Arg Cys Pro Leu Val 
    290                 295                 300                 


Ala Trp Pro Pro Ser Ala Glu Pro Gln Val His Arg Asn Ile His Ser 
305                 310                 315                 320 


His Gly Leu Arg Ser Asn Leu Gln Glu Ile Phe Leu Pro Ala Phe Pro 
                325                 330                 335     


Cys His Glu Arg Lys Lys Gln Glu 
            340                 


<210>  1482
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  1482

Met Gln Pro Leu Glu Val Gly Leu Val Pro Ala Pro Ala Gly Glu Pro 
1               5                   10                  15      


Arg Leu Thr Arg Trp Leu Arg Arg Gly Ser Gly Ile Leu Ala His Leu 
            20                  25                  30          


Val Ala Leu Gly Phe Thr Ile Phe Leu Thr Ala Leu Ser Arg Pro Gly 
        35                  40                  45              


Thr Lys Thr Gly Pro Leu Met Glu Asp Arg Ser Glu Gly Gly Arg Ala 
    50                  55                  60                  


Arg Trp Val Met Pro Glu Ile Pro Ala Leu Trp Glu Ala Asp Ala Gly 
65                  70                  75                  80  


Gly Ser Leu Glu Phe Cys Leu Cys Met Ala Glu Ala Ile Leu Leu Phe 
                85                  90                  95      


Ser Pro Glu His Ser Leu Phe Phe Phe Cys Ser Arg Lys Ala Arg Ile 
            100                 105                 110         


Arg Leu His Trp Ala Gly Gln Thr Leu Ala Ile Leu Cys Ala Ala Leu 
        115                 120                 125             


Gly Leu Gly Phe Ile Ile Ser Ser Arg Thr Arg Ser Glu Leu Pro His 
    130                 135                 140                 


Leu Val Ser Trp His Ser Trp Val Gly Ala Leu Thr Leu Leu Ala Thr 
145                 150                 155                 160 


Ala Val Gln Ala Leu Cys Gly Leu Cys Leu Leu Cys Pro Arg Ala Ala 
                165                 170                 175     


Arg Val Ser Arg Val Ala Arg Leu Lys Leu Tyr His Leu Thr Cys Gly 
            180                 185                 190         


Leu Val Val Tyr Leu Met Ala Thr Val Thr Val Leu Leu Gly Met Tyr 
        195                 200                 205             


Ser Val Trp Phe Gln Ala Gln Ile Lys Gly Ala Ala Trp Tyr Leu Cys 
    210                 215                 220                 


Leu Ala Leu Pro Val Tyr Pro Ala Leu Val Ile Met His Gln Ile Ser 
225                 230                 235                 240 


Arg Ser Tyr Leu Pro Arg Lys Lys Met Glu Met 
                245                 250     


<210>  1483
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  1483

Met Gln Pro Leu Glu Phe Cys Leu Cys Met Ala Glu Ala Ile Leu Leu 
1               5                   10                  15      


Phe Ser Pro Glu His Ser Leu Phe Phe Phe Cys Ser Arg Lys Ala Arg 
            20                  25                  30          


Ile Arg Leu His Trp Ala Gly Gln Thr Leu Ala Ile Leu Cys Ala Ala 
        35                  40                  45              


Leu Gly Leu Gly Phe Ile Ile Ser Ser Arg Thr Arg Ser Glu Leu Pro 
    50                  55                  60                  


His Leu Val Ser Trp His Ser Trp Val Gly Ala Leu Thr Leu Leu Ala 
65                  70                  75                  80  


Thr Ala Val Gln Ala Leu Cys Gly Leu Cys Leu Leu Cys Pro Arg Ala 
                85                  90                  95      


Ala Arg Val Ser Arg Val Ala Arg Leu Lys Leu Tyr His Leu Thr Cys 
            100                 105                 110         


Gly Leu Val Val Tyr Leu Met Ala Thr Val Thr Val Leu Leu Gly Met 
        115                 120                 125             


Tyr Ser Val Trp Phe Gln Ala Gln Ile Lys Gly Ala Ala Trp Tyr Leu 
    130                 135                 140                 


Cys Leu Ala Leu Pro Val Tyr Pro Ala Leu Val Ile Met His Gln Ile 
145                 150                 155                 160 


Ser Arg Ser Tyr Leu Pro Arg Lys Lys Met Glu Met 
                165                 170         


<210>  1484
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  1484

Met Gln Pro Leu Glu Val Gly Leu Val Pro Ala Pro Ala Gly Glu Pro 
1               5                   10                  15      


Arg Leu Thr Arg Trp Leu Arg Arg Gly Ser Gly Ile Leu Ala His Leu 
            20                  25                  30          


Val Ala Leu Gly Phe Thr Ile Phe Leu Thr Ala Leu Ser Arg Pro Gly 
        35                  40                  45              


Thr Lys Thr Gly Pro Leu Met Glu Asp Arg Ser Glu Gly Gly Arg Ala 
    50                  55                  60                  


Arg Trp Val Met Pro Glu Ile Pro Ala Leu Trp Glu Ala Asp Ala Gly 
65                  70                  75                  80  


Gly Ser Leu Glu Val Phe Ser Pro Gly Thr Leu Tyr Ser Trp Pro Trp 
                85                  90                  95      


Arg Ser Ala Ser Ala Trp Leu Lys Pro Ser Tyr Ser Ser His Leu Asn 
            100                 105                 110         


Thr Pro Cys Ser Ser Ser Ala Pro Glu Lys His Gly Ser Gly Ser Thr 
        115                 120                 125             


Gly Gln Gly Arg Pro 
    130             


<210>  1485
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  1485

Met Gln Pro Leu Glu Val Gly Leu Val Pro Ala Pro Ala Gly Glu Pro 
1               5                   10                  15      


Arg Leu Thr Arg Trp Leu Arg Arg Gly Ser Gly Ile Leu Ala His Leu 
            20                  25                  30          


Val Ala Leu Gly Phe Thr Ile Phe Leu Thr Ala Leu Ser Arg Pro Gly 
        35                  40                  45              


Thr Lys Thr Gly Pro Leu Met Glu Asp Arg Ser Glu Gly Gly Arg Ala 
    50                  55                  60                  


Arg Trp Val Met Pro Glu Ile Pro Ala Leu Trp Glu Ala Asp Ala Gly 
65                  70                  75                  80  


Gly Ser Leu Glu Val Phe Ser Pro Gly Thr Leu Tyr Ser Trp Pro Trp 
                85                  90                  95      


Arg Met Tyr Glu Ser Thr Ser Phe Phe Ser Gly Leu Gln Ala Arg His 
            100                 105                 110         


Glu Ala Tyr Trp Leu Ser Pro Met Phe Thr Val Leu Pro Leu His Gly 
        115                 120                 125             


<210>  1486
<211>  1464
<212>  PRT
<213>  Homo sapiens

<400>  1486

Met Gly Arg Val Gly Tyr Trp Thr Leu Leu Val Leu Pro Ala Leu Leu 
1               5                   10                  15      


Val Trp Arg Gly Pro Ala Pro Ser Ala Ala Ala Glu Lys Gly Pro Pro 
            20                  25                  30          


Ala Leu Asn Ile Ala Val Met Leu Gly His Ser His Asp Val Thr Glu 
        35                  40                  45              


Arg Glu Leu Arg Thr Leu Trp Gly Pro Glu Gln Ala Ala Gly Leu Pro 
    50                  55                  60                  


Leu Asp Val Asn Val Val Ala Leu Leu Met Asn Arg Thr Asp Pro Lys 
65                  70                  75                  80  


Ser Leu Ile Thr His Val Cys Asp Leu Met Ser Gly Ala Arg Ile His 
                85                  90                  95      


Gly Leu Val Phe Gly Asp Asp Thr Asp Gln Glu Ala Val Ala Gln Met 
            100                 105                 110         


Leu Asp Phe Ile Ser Ser His Thr Phe Val Pro Ile Leu Gly Ile His 
        115                 120                 125             


Gly Gly Ala Ser Met Ile Met Ala Asp Lys Asp Pro Thr Ser Thr Phe 
    130                 135                 140                 


Phe Gln Phe Gly Ala Ser Ile Gln Gln Gln Ala Thr Val Met Leu Lys 
145                 150                 155                 160 


Ile Met Gln Asp Tyr Asp Trp His Val Phe Ser Leu Val Thr Thr Ile 
                165                 170                 175     


Phe Pro Gly Tyr Arg Glu Phe Ile Ser Phe Val Lys Thr Thr Val Asp 
            180                 185                 190         


Asn Ser Phe Val Gly Trp Asp Met Gln Asn Val Ile Thr Leu Asp Thr 
        195                 200                 205             


Ser Phe Glu Asp Ala Lys Thr Gln Val Gln Leu Lys Lys Ile His Ser 
    210                 215                 220                 


Ser Val Ile Leu Leu Tyr Cys Ser Lys Asp Glu Ala Val Leu Ile Leu 
225                 230                 235                 240 


Ser Glu Ala Arg Ser Leu Gly Leu Thr Gly Tyr Asp Phe Phe Trp Ile 
                245                 250                 255     


Val Pro Ser Leu Val Ser Gly Asn Thr Glu Leu Ile Pro Lys Glu Phe 
            260                 265                 270         


Pro Ser Gly Leu Ile Ser Val Ser Tyr Asp Asp Trp Asp Tyr Ser Leu 
        275                 280                 285             


Glu Ala Arg Val Arg Asp Gly Ile Gly Ile Leu Thr Thr Ala Ala Ser 
    290                 295                 300                 


Ser Met Leu Glu Lys Phe Ser Tyr Ile Pro Glu Ala Lys Ala Ser Cys 
305                 310                 315                 320 


Tyr Gly Gln Met Glu Arg Pro Glu Val Pro Met His Thr Leu His Pro 
                325                 330                 335     


Phe Met Val Asn Val Thr Trp Asp Gly Lys Asp Leu Ser Phe Thr Glu 
            340                 345                 350         


Glu Gly Tyr Gln Val His Pro Arg Leu Val Val Ile Val Leu Asn Lys 
        355                 360                 365             


Asp Arg Glu Trp Glu Lys Val Gly Lys Trp Glu Asn His Thr Leu Ser 
    370                 375                 380                 


Leu Arg His Ala Val Trp Pro Arg Tyr Lys Ser Phe Ser Asp Cys Glu 
385                 390                 395                 400 


Pro Asp Asp Asn His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe 
                405                 410                 415     


Val Ile Val Glu Asp Ile Asp Pro Leu Thr Glu Thr Cys Val Arg Asn 
            420                 425                 430         


Thr Val Pro Cys Arg Lys Phe Val Lys Ile Asn Asn Ser Thr Asn Glu 
        435                 440                 445             


Gly Met Asn Val Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu 
    450                 455                 460                 


Lys Lys Leu Ser Arg Thr Val Lys Phe Thr Tyr Asp Leu Tyr Leu Val 
465                 470                 475                 480 


Thr Asn Gly Lys His Gly Lys Lys Val Asn Asn Val Trp Asn Gly Met 
                485                 490                 495     


Ile Gly Glu Val Val Tyr Gln Arg Ala Val Met Ala Val Gly Ser Leu 
            500                 505                 510         


Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro Phe 
        515                 520                 525             


Val Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr Val 
    530                 535                 540                 


Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Ser Val Trp Val Met 
545                 550                 555                 560 


Met Phe Val Met Leu Leu Ile Val Ser Ala Ile Ala Val Phe Val Phe 
                565                 570                 575     


Glu Tyr Phe Ser Pro Val Gly Tyr Asn Arg Asn Leu Ala Lys Gly Lys 
            580                 585                 590         


Ala Pro His Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu Leu 
        595                 600                 605             


Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys Gly 
    610                 615                 620                 


Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val Ile 
625                 630                 635                 640 


Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu 
                645                 650                 655     


Glu Phe Val Asp Gln Val Thr Gly Leu Ser Asp Lys Lys Phe Gln Arg 
            660                 665                 670         


Pro His Asp Tyr Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn Gly 
        675                 680                 685             


Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Pro Tyr Met His Gln Tyr 
    690                 695                 700                 


Met Thr Lys Phe Asn Gln Lys Gly Val Glu Asp Ala Leu Val Ser Leu 
705                 710                 715                 720 


Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn 
                725                 730                 735     


Tyr Lys Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser 
            740                 745                 750         


Gly Tyr Ile Phe Ala Thr Thr Gly Tyr Gly Ile Ala Leu Gln Lys Gly 
        755                 760                 765             


Ser Pro Trp Lys Arg Gln Ile Asp Leu Ala Leu Leu Gln Phe Val Gly 
    770                 775                 780                 


Asp Gly Glu Met Glu Glu Leu Glu Thr Leu Trp Leu Thr Gly Ile Cys 
785                 790                 795                 800 


His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp Asn 
                805                 810                 815     


Met Ala Gly Val Phe Tyr Met Leu Ala Ala Ala Met Ala Leu Ser Leu 
            820                 825                 830         


Ile Thr Phe Ile Trp Glu His Leu Phe Tyr Trp Lys Leu Arg Phe Cys 
        835                 840                 845             


Phe Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Phe Ser Ile Ser 
    850                 855                 860                 


Arg Gly Ile Tyr Ser Cys Ile His Gly Val His Ile Glu Glu Lys Lys 
865                 870                 875                 880 


Lys Ser Pro Asp Phe Asn Leu Thr Gly Ser Gln Ser Asn Met Leu Lys 
                885                 890                 895     


Leu Leu Arg Ser Ala Lys Asn Ile Ser Ser Met Ser Asn Met Asn Ser 
            900                 905                 910         


Ser Arg Met Asp Ser Pro Lys Arg Ala Ala Asp Phe Ile Gln Arg Gly 
        915                 920                 925             


Ser Leu Ile Met Asp Met Val Ser Asp Lys Gly Asn Leu Met Tyr Ser 
    930                 935                 940                 


Asp Asn Arg Ser Phe Gln Gly Lys Glu Ser Ile Phe Gly Asp Asn Met 
945                 950                 955                 960 


Asn Glu Leu Gln Thr Phe Val Ala Asn Arg Gln Lys Asp Asn Leu Asn 
                965                 970                 975     


Asn Tyr Val Phe Gln Gly Gln His Pro Leu Thr Leu Asn Glu Ser Asn 
            980                 985                 990         


Pro Asn Thr Val Glu Val Ala Val  Ser Thr Glu Ser Lys  Ala Asn Ser 
        995                 1000                 1005             


Arg Pro  Arg Gln Leu Trp Lys  Lys Ser Val Asp Ser  Ile Arg Gln 
    1010                 1015                 1020             


Asp Ser  Leu Ser Gln Asn Pro  Val Ser Gln Arg Asp  Glu Ala Thr 
    1025                 1030                 1035             


Ala Glu  Asn Arg Thr His Ser  Leu Lys Ser Pro Arg  Tyr Leu Pro 
    1040                 1045                 1050             


Glu Glu  Met Ala His Ser Asp  Ile Ser Glu Thr Ser  Asn Arg Ala 
    1055                 1060                 1065             


Thr Cys  His Arg Glu Pro Asp  Asn Ser Lys Asn His  Lys Thr Lys 
    1070                 1075                 1080             


Asp Asn  Phe Lys Arg Ser Val  Ala Ser Lys Tyr Pro  Lys Asp Cys 
    1085                 1090                 1095             


Ser Glu  Val Glu Arg Thr Tyr  Leu Lys Thr Lys Ser  Ser Ser Pro 
    1100                 1105                 1110             


Arg Asp  Lys Ile Tyr Thr Ile  Asp Gly Glu Lys Glu  Pro Gly Phe 
    1115                 1120                 1125             


His Leu  Asp Pro Pro Gln Phe  Val Glu Asn Val Thr  Leu Pro Glu 
    1130                 1135                 1140             


Asn Val  Asp Phe Pro Asp Pro  Tyr Gln Asp Pro Ser  Glu Asn Phe 
    1145                 1150                 1155             


Arg Lys  Gly Asp Ser Thr Leu  Pro Met Asn Arg Asn  Pro Leu His 
    1160                 1165                 1170             


Asn Glu  Glu Gly Leu Ser Asn  Asn Asp Gln Tyr Lys  Leu Tyr Ser 
    1175                 1180                 1185             


Lys His  Phe Thr Leu Lys Asp  Lys Gly Ser Pro His  Ser Glu Thr 
    1190                 1195                 1200             


Ser Glu  Arg Tyr Arg Gln Asn  Ser Thr His Cys Arg  Ser Cys Leu 
    1205                 1210                 1215             


Ser Asn  Met Pro Thr Tyr Ser  Gly His Phe Thr Met  Arg Ser Pro 
    1220                 1225                 1230             


Phe Lys  Cys Asp Ala Cys Leu  Arg Met Gly Asn Leu  Tyr Asp Ile 
    1235                 1240                 1245             


Asp Glu  Asp Gln Met Leu Gln  Glu Thr Gly Asn Pro  Ala Thr Gly 
    1250                 1255                 1260             


Glu Gln  Val Tyr Gln Gln Asp  Trp Ala Gln Asn Asn  Ala Leu Gln 
    1265                 1270                 1275             


Leu Gln  Lys Asn Lys Leu Arg  Ile Ser Arg Gln His  Ser Tyr Asp 
    1280                 1285                 1290             


Asn Ile  Val Asp Lys Pro Arg  Glu Leu Asp Leu Ser  Arg Pro Ser 
    1295                 1300                 1305             


Arg Ser  Ile Ser Leu Lys Asp  Arg Glu Arg Leu Leu  Glu Gly Asn 
    1310                 1315                 1320             


Phe Tyr  Gly Ser Leu Phe Ser  Val Pro Ser Ser Lys  Leu Ser Gly 
    1325                 1330                 1335             


Lys Lys  Ser Ser Leu Phe Pro  Gln Gly Leu Glu Asp  Ser Lys Arg 
    1340                 1345                 1350             


Ser Lys  Ser Leu Leu Pro Asp  His Thr Ser Asp Asn  Pro Phe Leu 
    1355                 1360                 1365             


His Ser  His Arg Asp Asp Gln  Arg Leu Val Ile Gly  Arg Cys Pro 
    1370                 1375                 1380             


Ser Asp  Pro Tyr Lys His Ser  Leu Pro Ser Gln Ala  Val Asn Asp 
    1385                 1390                 1395             


Ser Tyr  Leu Arg Ser Ser Leu  Arg Ser Thr Ala Ser  Tyr Cys Ser 
    1400                 1405                 1410             


Arg Asp  Ser Arg Gly His Asn  Asp Val Tyr Ile Ser  Glu His Val 
    1415                 1420                 1425             


Met Pro  Tyr Ala Ala Asn Lys  Asn Asn Met Tyr Ser  Thr Pro Arg 
    1430                 1435                 1440             


Val Leu  Asn Ser Cys Ser Asn  Arg Arg Val Tyr Lys  Lys Met Pro 
    1445                 1450                 1455             


Ser Ile  Glu Ser Asp Val 
    1460                 


<210>  1487
<211>  1281
<212>  PRT
<213>  Homo sapiens

<400>  1487

Met Gly Arg Val Gly Tyr Trp Thr Leu Leu Val Leu Pro Ala Leu Leu 
1               5                   10                  15      


Val Trp Arg Gly Pro Ala Pro Ser Ala Ala Ala Glu Lys Gly Pro Pro 
            20                  25                  30          


Ala Leu Asn Ile Ala Val Met Leu Gly His Ser His Asp Val Thr Glu 
        35                  40                  45              


Arg Glu Leu Arg Thr Leu Trp Gly Pro Glu Gln Ala Ala Gly Leu Pro 
    50                  55                  60                  


Leu Asp Val Asn Val Val Ala Leu Leu Met Asn Arg Thr Asp Pro Lys 
65                  70                  75                  80  


Ser Leu Ile Thr His Val Cys Asp Leu Met Ser Gly Ala Arg Ile His 
                85                  90                  95      


Gly Leu Val Phe Gly Asp Asp Thr Asp Gln Glu Ala Val Ala Gln Met 
            100                 105                 110         


Leu Asp Phe Ile Ser Ser His Thr Phe Val Pro Ile Leu Gly Ile His 
        115                 120                 125             


Gly Gly Ala Ser Met Ile Met Ala Asp Lys Asp Pro Thr Ser Thr Phe 
    130                 135                 140                 


Phe Gln Phe Gly Ala Ser Ile Gln Gln Gln Ala Thr Val Met Leu Lys 
145                 150                 155                 160 


Ile Met Gln Asp Tyr Asp Trp His Val Phe Ser Leu Val Thr Thr Ile 
                165                 170                 175     


Phe Pro Gly Tyr Arg Glu Phe Ile Ser Phe Val Lys Thr Thr Val Asp 
            180                 185                 190         


Asn Ser Phe Val Gly Trp Asp Met Gln Asn Val Ile Thr Leu Asp Thr 
        195                 200                 205             


Ser Phe Glu Asp Ala Lys Thr Gln Val Gln Leu Lys Lys Ile His Ser 
    210                 215                 220                 


Ser Val Ile Leu Leu Tyr Cys Ser Lys Asp Glu Ala Val Leu Ile Leu 
225                 230                 235                 240 


Ser Glu Ala Arg Ser Leu Gly Leu Thr Gly Tyr Asp Phe Phe Trp Ile 
                245                 250                 255     


Val Pro Ser Leu Val Ser Gly Asn Thr Glu Leu Ile Pro Lys Glu Phe 
            260                 265                 270         


Pro Ser Gly Leu Ile Ser Val Ser Tyr Asp Asp Trp Asp Tyr Ser Leu 
        275                 280                 285             


Glu Ala Arg Val Arg Asp Gly Ile Gly Ile Leu Thr Thr Ala Ala Ser 
    290                 295                 300                 


Ser Met Leu Glu Lys Phe Ser Tyr Ile Pro Glu Ala Lys Ala Ser Cys 
305                 310                 315                 320 


Tyr Gly Gln Met Glu Arg Pro Glu Val Pro Met His Thr Leu His Pro 
                325                 330                 335     


Phe Met Val Asn Val Thr Trp Asp Gly Lys Asp Leu Ser Phe Thr Glu 
            340                 345                 350         


Glu Gly Tyr Gln Val His Pro Arg Leu Val Val Ile Val Leu Asn Lys 
        355                 360                 365             


Asp Arg Glu Trp Glu Lys Val Gly Lys Trp Glu Asn His Thr Leu Ser 
    370                 375                 380                 


Leu Arg His Ala Val Trp Pro Arg Tyr Lys Ser Phe Ser Asp Cys Glu 
385                 390                 395                 400 


Pro Asp Asp Asn His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe 
                405                 410                 415     


Val Ile Val Glu Asp Ile Asp Pro Leu Thr Glu Thr Cys Val Arg Asn 
            420                 425                 430         


Thr Val Pro Cys Arg Lys Phe Val Lys Ile Asn Asn Ser Thr Asn Glu 
        435                 440                 445             


Gly Met Asn Val Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu 
    450                 455                 460                 


Lys Lys Leu Ser Arg Thr Val Lys Phe Thr Tyr Asp Leu Tyr Leu Val 
465                 470                 475                 480 


Thr Asn Gly Lys His Gly Lys Lys Val Asn Asn Val Trp Asn Gly Met 
                485                 490                 495     


Ile Gly Glu Val Val Tyr Gln Arg Ala Val Met Ala Val Gly Ser Leu 
            500                 505                 510         


Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro Phe 
        515                 520                 525             


Val Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr Val 
    530                 535                 540                 


Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Ser Val Trp Val Met 
545                 550                 555                 560 


Met Phe Val Met Leu Leu Ile Val Ser Ala Ile Ala Val Phe Val Phe 
                565                 570                 575     


Glu Tyr Phe Ser Pro Val Gly Tyr Asn Arg Asn Leu Ala Lys Gly Lys 
            580                 585                 590         


Ala Pro His Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu Leu 
        595                 600                 605             


Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys Gly 
    610                 615                 620                 


Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val Ile 
625                 630                 635                 640 


Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu 
                645                 650                 655     


Glu Phe Val Asp Gln Val Thr Gly Leu Ser Asp Lys Lys Phe Gln Arg 
            660                 665                 670         


Pro His Asp Tyr Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn Gly 
        675                 680                 685             


Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Pro Tyr Met His Gln Tyr 
    690                 695                 700                 


Met Thr Lys Phe Asn Gln Lys Gly Val Glu Asp Ala Leu Val Ser Leu 
705                 710                 715                 720 


Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn 
                725                 730                 735     


Tyr Lys Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser 
            740                 745                 750         


Gly Tyr Ile Phe Ala Thr Thr Gly Tyr Gly Ile Ala Leu Gln Lys Gly 
        755                 760                 765             


Ser Pro Trp Lys Arg Gln Ile Asp Leu Ala Leu Leu Gln Phe Val Gly 
    770                 775                 780                 


Asp Gly Glu Met Glu Glu Leu Glu Thr Leu Trp Leu Thr Gly Ile Cys 
785                 790                 795                 800 


His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp Asn 
                805                 810                 815     


Met Ala Gly Val Phe Tyr Met Leu Ala Ala Ala Met Ala Leu Ser Leu 
            820                 825                 830         


Ile Thr Phe Ile Trp Glu His Leu Phe Tyr Trp Lys Leu Arg Phe Cys 
        835                 840                 845             


Phe Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Phe Ser Ile Ser 
    850                 855                 860                 


Arg Gly Ile Tyr Ser Cys Ile His Gly Val His Ile Glu Glu Lys Lys 
865                 870                 875                 880 


Lys Ser Pro Asp Phe Asn Leu Thr Gly Ser Gln Ser Asn Met Leu Lys 
                885                 890                 895     


Leu Leu Arg Ser Ala Lys Asn Ile Ser Ser Met Ser Asn Met Asn Ser 
            900                 905                 910         


Ser Arg Met Asp Ser Pro Lys Arg Ala Ala Asp Phe Ile Gln Arg Gly 
        915                 920                 925             


Ser Leu Ile Met Asp Met Val Ser Asp Lys Gly Asn Leu Met Tyr Ser 
    930                 935                 940                 


Asp Asn Arg Ser Phe Gln Gly Lys Glu Ser Ile Phe Gly Asp Asn Met 
945                 950                 955                 960 


Asn Glu Leu Gln Thr Phe Val Ala Asn Arg Gln Lys Asp Asn Leu Asn 
                965                 970                 975     


Asn Tyr Val Phe Gln Gly Gln His Pro Leu Thr Leu Asn Glu Ser Asn 
            980                 985                 990         


Pro Asn Thr Val Glu Val Ala Val  Ser Thr Glu Ser Lys  Ala Asn Ser 
        995                 1000                 1005             


Arg Pro  Arg Gln Leu Trp Lys  Lys Ser Val Asp Ser  Ile Arg Gln 
    1010                 1015                 1020             


Asp Ser  Leu Ser Gln Asn Pro  Val Ser Gln Arg Asp  Glu Ala Thr 
    1025                 1030                 1035             


Ala Glu  Asn Arg Thr His Ser  Leu Lys Ser Pro Arg  Tyr Leu Pro 
    1040                 1045                 1050             


Glu Glu  Met Ala His Ser Asp  Ile Ser Glu Thr Ser  Asn Arg Ala 
    1055                 1060                 1065             


Thr Cys  His Arg Glu Pro Asp  Asn Ser Lys Asn His  Lys Thr Lys 
    1070                 1075                 1080             


Asp Asn  Phe Lys Arg Ser Val  Ala Ser Lys Tyr Pro  Lys Asp Cys 
    1085                 1090                 1095             


Ser Glu  Val Glu Arg Thr Tyr  Leu Lys Thr Lys Ser  Ser Ser Pro 
    1100                 1105                 1110             


Arg Asp  Lys Ile Tyr Thr Ile  Asp Gly Glu Lys Glu  Pro Gly Phe 
    1115                 1120                 1125             


His Leu  Asp Pro Pro Gln Phe  Val Glu Asn Val Thr  Leu Pro Glu 
    1130                 1135                 1140             


Asn Val  Asp Phe Pro Asp Pro  Tyr Gln Asp Pro Ser  Glu Asn Phe 
    1145                 1150                 1155             


Arg Lys  Gly Asp Ser Thr Leu  Pro Met Asn Arg Asn  Pro Leu His 
    1160                 1165                 1170             


Asn Glu  Glu Gly Leu Ser Asn  Asn Asp Gln Tyr Lys  Leu Tyr Ser 
    1175                 1180                 1185             


Lys His  Phe Thr Leu Lys Asp  Lys Gly Ser Pro His  Ser Glu Thr 
    1190                 1195                 1200             


Ser Glu  Arg Tyr Arg Gln Asn  Ser Thr His Cys Arg  Ser Cys Leu 
    1205                 1210                 1215             


Ser Asn  Met Pro Thr Tyr Ser  Gly His Phe Thr Met  Arg Ser Pro 
    1220                 1225                 1230             


Phe Lys  Cys Asp Ala Cys Leu  Arg Met Gly Asn Leu  Tyr Asp Ile 
    1235                 1240                 1245             


Asp Glu  Asp Gln Met Leu Gln  Glu Thr Gly Met Thr  Asn Ala Trp 
    1250                 1255                 1260             


Leu Leu  Gly Asp Ala Pro Arg  Thr Leu Thr Asn Thr  Arg Cys His 
    1265                 1270                 1275             


Pro Arg  Arg 
    1280     


<210>  1488
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  1488

Met Ala Ala Ala Thr Arg Gly Cys Arg Pro Trp Gly Ser Leu Leu Gly 
1               5                   10                  15      


Leu Leu Gly Leu Val Ser Ala Ala Ala Ala Ala Trp Asp Leu Ala Ser 
            20                  25                  30          


Leu Arg Cys Thr Leu Gly Ala Phe Cys Glu Cys Asp Phe Arg Pro Asp 
        35                  40                  45              


Leu Pro Gly Leu Glu Cys Asp Leu Ala Gln His Leu Ala Gly Gln His 
    50                  55                  60                  


Leu Ala Lys Ala Leu Val Val Lys Ala Leu Lys Ala Phe Val Arg Asp 
65                  70                  75                  80  


Pro Ala Pro Thr Lys Pro Leu Val Leu Ser Leu His Gly Trp Thr Gly 
                85                  90                  95      


Thr Gly Lys Ser Tyr Val Ser Ser Leu Leu Ala His Tyr Leu Phe Gln 
            100                 105                 110         


Gly Gly Leu Arg Ser Pro Arg Val His His Phe Ser Pro Val Leu His 
        115                 120                 125             


Phe Pro His Pro Ser His Ile Glu Arg Tyr Lys Lys Asp Leu Lys Ser 
    130                 135                 140                 


Trp Val Gln Gly Asn Leu Thr Ala Cys Gly Arg Ser Leu Phe Leu Phe 
145                 150                 155                 160 


Asp Glu Met Asp Lys Met Pro Pro Gly Leu Met Glu Val Leu Arg Pro 
                165                 170                 175     


Phe Leu Gly Ser Ser Trp Val Val Tyr Gly Thr Asn Tyr Arg Lys Ala 
            180                 185                 190         


Ile Phe Ile Phe Ile Arg Trp Leu Leu Lys Leu Gly His His Gly Arg 
        195                 200                 205             


Ala Pro Pro Arg Arg Ser Gly Ala Leu Pro Pro Ala Pro Ala Ala Pro 
    210                 215                 220                 


Arg Pro Ala Leu Arg Ala Gln Arg Ala Gly Pro Ala Gly Pro Gly Ala 
225                 230                 235                 240 


Lys Gly 
        


<210>  1489
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  1489

Met Ala Ala Ala Thr Arg Gly Cys Arg Pro Trp Gly Ser Leu Leu Gly 
1               5                   10                  15      


Leu Leu Gly Leu Val Ser Ala Ala Ala Ala Ala Trp Asp Leu Ala Ser 
            20                  25                  30          


Leu Arg Cys Thr Leu Gly Ala Phe Cys Glu Cys Asp Phe Arg Pro Asp 
        35                  40                  45              


Leu Pro Glu Gly Ser Glu Glu Leu Gly Pro Arg Glu Pro His Cys Leu 
    50                  55                  60                  


Trp Pro Leu Pro Leu Pro Leu Arg 
65                  70          


<210>  1490
<211>  1237
<212>  PRT
<213>  Homo sapiens

<400>  1490

Met Glu Glu Glu Asp Thr Lys Arg Glu Val Pro Lys Glu Asp Gly Val 
1               5                   10                  15      


Gly Asp Val Gln His Phe Asp Ser Ser Lys Ile Met Glu Glu His Ser 
            20                  25                  30          


Tyr Ile Gln Lys Glu Leu Asp Leu Gln Asn Gly Ser Leu Glu Glu Asp 
        35                  40                  45              


Ser Val Val His Ser Val Glu Asn Asp Ser Gln Asn Met Met Glu Ser 
    50                  55                  60                  


Leu Ser Pro Lys Lys Tyr Ser Ser Ser Leu Arg Phe Lys Ala Asn Gly 
65                  70                  75                  80  


Asp Tyr Ser Gly Ser Tyr Leu Thr Leu Ser Gln Pro Val Pro Ala Lys 
                85                  90                  95      


Arg Ser Pro Ser Pro Leu Gly Thr Ser Val Arg Ser Ser Pro Ser Leu 
            100                 105                 110         


Ala Lys Ile Gln Gly Ser Lys Gln Phe Ser Tyr Asp Gly Thr Asp Lys 
        115                 120                 125             


Asn Ile Pro Met Lys Pro Pro Thr Pro Leu Leu Asn Thr Thr Ser Ser 
    130                 135                 140                 


Leu Ser Gly Tyr Pro Leu Gly Arg Ala Asp Phe Asp His Tyr Thr Gly 
145                 150                 155                 160 


Arg Asp Ser Glu Arg Ala Leu Arg Leu Ser Glu Lys Pro Pro Tyr Ser 
                165                 170                 175     


Lys Tyr Ser Ser Arg His Lys Ser His Asp Asn Val Tyr Ser Leu Gly 
            180                 185                 190         


Gly Leu Glu Gly Arg Lys Ala Ser Gly Ser Leu Leu Ala Met Trp Asn 
        195                 200                 205             


Gly Ser Ser Leu Ser Asp Ala Gly Pro Pro Pro Ile Ser Arg Ser Gly 
    210                 215                 220                 


Ala Ala Ser Met Pro Ser Ser Pro Lys Gln Ala Arg Lys Met Ser Ile 
225                 230                 235                 240 


Gln Asp Ser Leu Ala Leu Gln Pro Lys Leu Thr Arg His Lys Glu Leu 
                245                 250                 255     


Ala Ser Glu Asn Ile Asn Leu Arg Thr Arg Lys Tyr Ser Ser Ser Ser 
            260                 265                 270         


Leu Ser His Met Gly Ala Tyr Ser Arg Ser Leu Pro Arg Leu Tyr Arg 
        275                 280                 285             


Ala Thr Glu Asn Gln Leu Thr Pro Leu Ser Leu Pro Pro Arg Asn Ser 
    290                 295                 300                 


Leu Gly Asn Ser Lys Arg Thr Lys Leu Gly Glu Lys Asp Leu Pro His 
305                 310                 315                 320 


Ser Val Ile Asp Asn Asp Asn Tyr Leu Asn Phe Ser Ser Leu Ser Ser 
                325                 330                 335     


Gly Ala Leu Pro Tyr Lys Thr Ser Ala Ser Glu Gly Asn Pro Tyr Val 
            340                 345                 350         


Ser Ser Thr Leu Ser Val Pro Ala Ser Pro Arg Val Ala Arg Lys Met 
        355                 360                 365             


Leu Leu Ala Ser Thr Ser Ser Cys Ala Ser Asp Asp Phe Asp Gln Ala 
    370                 375                 380                 


Ser Tyr Val Gly Thr Asn Pro Ser His Ser Leu Leu Ala Gly Glu Ser 
385                 390                 395                 400 


Asp Arg Val Phe Ala Thr Arg Arg Asn Phe Ser Cys Gly Ser Val Glu 
                405                 410                 415     


Phe Asp Glu Ala Asp Leu Glu Ser Leu Arg Gln Ala Ser Gly Thr Pro 
            420                 425                 430         


Gln Pro Ala Leu Arg Glu Arg Lys Ser Ser Ile Ser Ser Ile Ser Gly 
        435                 440                 445             


Arg Asp Asp Leu Met Asp Tyr His Arg Arg Gln Arg Glu Glu Arg Leu 
    450                 455                 460                 


Arg Glu Gln Glu Met Glu Arg Leu Glu Arg Gln Arg Leu Glu Thr Ile 
465                 470                 475                 480 


Leu Ser Leu Cys Ala Glu Tyr Thr Lys Pro Asp Ser Arg Leu Ser Thr 
                485                 490                 495     


Gly Thr Thr Val Glu Asp Val Gln Lys Ile Asn Lys Glu Leu Glu Lys 
            500                 505                 510         


Leu Gln Leu Ser Asp Glu Glu Ser Val Phe Glu Glu Ala Leu Met Ser 
        515                 520                 525             


Pro Asp Thr Arg Tyr Arg Cys His Arg Lys Asp Ser Leu Pro Asp Ala 
    530                 535                 540                 


Asp Leu Ala Ser Cys Gly Ser Leu Ser Gln Ser Ser Ala Ser Phe Phe 
545                 550                 555                 560 


Thr Pro Arg Ser Thr Arg Asn Asp Glu Leu Leu Ser Asp Leu Thr Arg 
                565                 570                 575     


Thr Pro Pro Pro Pro Ser Ser Thr Phe Pro Lys Ala Ser Ser Glu Ser 
            580                 585                 590         


Ser Tyr Leu Ser Ile Leu Pro Lys Thr Pro Glu Gly Ile Ser Glu Glu 
        595                 600                 605             


Gln Arg Ser Gln Glu Leu Ala Ala Met Glu Glu Thr Arg Ile Val Ile 
    610                 615                 620                 


Leu Asn Asn Leu Glu Glu Leu Lys Gln Lys Ile Lys Asp Ile Asn Asp 
625                 630                 635                 640 


Gln Met Asp Glu Ser Phe Arg Glu Leu Asp Met Glu Cys Ala Leu Leu 
                645                 650                 655     


Asp Gly Glu Gln Lys Ser Glu Thr Thr Glu Leu Met Lys Glu Lys Glu 
            660                 665                 670         


Ile Leu Asp His Leu Asn Arg Lys Ile Ala Glu Leu Glu Lys Asn Ile 
        675                 680                 685             


Val Gly Glu Lys Thr Lys Asp Ala Asp Leu Leu Asp Val Glu Ser Lys 
    690                 695                 700                 


His Phe Glu Asp Leu Glu Phe Gln Gln Leu Glu His Glu Ser Arg Leu 
705                 710                 715                 720 


Asp Glu Glu Lys Glu Asn Leu Thr Gln Gln Leu Leu Arg Glu Val Ala 
                725                 730                 735     


Glu Tyr Gln Arg Asn Ile Val Ser Arg Lys Glu Lys Ile Ser Ala Leu 
            740                 745                 750         


Lys Lys Gln Ala Asn His Ile Val Gln Gln Ala Gln Arg Glu Gln Asp 
        755                 760                 765             


His Phe Val Lys Glu Lys Asn Asn Leu Ile Met Met Leu Gln Arg Glu 
    770                 775                 780                 


Lys Glu Asn Leu Cys Asn Leu Glu Lys Lys Tyr Ser Ser Leu Ser Gly 
785                 790                 795                 800 


Gly Lys Gly Phe Pro Val Asn Pro Asn Thr Leu Lys Glu Gly Tyr Ile 
                805                 810                 815     


Ser Val Asn Glu Ile Asn Glu Pro Cys Gly Asn Ser Thr Asn Leu Ser 
            820                 825                 830         


Pro Ser Thr Gln Phe Pro Ala Asp Ala Asp Ala Val Ala Thr Glu Pro 
        835                 840                 845             


Ala Thr Ala Val Leu Ala Ser Gln Pro Gln Ser Lys Glu His Phe Arg 
    850                 855                 860                 


Ser Leu Glu Glu Arg Lys Lys Gln His Lys Glu Gly Leu Tyr Leu Ser 
865                 870                 875                 880 


Asp Thr Leu Pro Arg Lys Lys Thr Thr Ser Ser Ile Ser Pro His Phe 
                885                 890                 895     


Ser Ser Ala Thr Met Gly Arg Ser Ile Thr Pro Lys Ala His Leu Pro 
            900                 905                 910         


Leu Gly Gln Ser Asn Ser Cys Gly Ser Val Leu Pro Pro Ser Leu Ala 
        915                 920                 925             


Ala Met Ala Lys Asp Ser Glu Ser Arg Arg Met Leu Arg Gly Tyr Asn 
    930                 935                 940                 


His Gln Gln Met Ser Glu Gly His Arg Gln Lys Ser Glu Phe Tyr Asn 
945                 950                 955                 960 


Arg Thr Ala Ser Glu Ser Asn Val Tyr Leu Asn Ser Phe His Tyr Pro 
                965                 970                 975     


Asp His Ser Tyr Lys Asp Gln Ala Phe Asp Thr Leu Ser Leu Asp Ser 
            980                 985                 990         


Ser Asp Ser Met Glu Thr Ser Ile  Ser Ala Cys Ser Pro  Asp Asn Ile 
        995                 1000                 1005             


Ser Ser  Ala Ser Thr Ser Asn  Ile Ala Arg Ile Glu  Glu Met Glu 
    1010                 1015                 1020             


Arg Leu  Leu Lys Gln Ala His  Ala Glu Lys Thr Arg  Leu Leu Glu 
    1025                 1030                 1035             


Ser Arg  Glu Arg Glu Met Glu  Ala Lys Lys Arg Ala  Leu Glu Glu 
    1040                 1045                 1050             


Glu Lys  Arg Arg Arg Glu Ile  Leu Glu Lys Arg Leu  Gln Glu Glu 
    1055                 1060                 1065             


Thr Ser  Gln Arg Gln Lys Leu  Ile Glu Lys Glu Val  Lys Ile Arg 
    1070                 1075                 1080             


Glu Arg  Gln Arg Ala Gln Ala  Arg Pro Leu Thr Arg  Tyr Leu Pro 
    1085                 1090                 1095             


Val Arg  Lys Glu Asp Phe Asp  Leu Arg Ser His Val  Glu Thr Ala 
    1100                 1105                 1110             


Gly His  Asn Ile Asp Thr Cys  Tyr His Val Ser Ile  Thr Glu Lys 
    1115                 1120                 1125             


Thr Cys  Arg Gly Phe Leu Ile  Lys Met Gly Gly Lys  Ile Lys Thr 
    1130                 1135                 1140             


Trp Lys  Lys Arg Trp Phe Val  Phe Asp Arg Asn Lys  Arg Thr Phe 
    1145                 1150                 1155             


Ser Tyr  Tyr Ala Asp Lys His  Glu Thr Lys Leu Lys  Gly Val Ile 
    1160                 1165                 1170             


Tyr Phe  Gln Ala Ile Glu Glu  Val Tyr Tyr Asp His  Leu Lys Asn 
    1175                 1180                 1185             


Ala Asn  Lys Ser Pro Asn Pro  Leu Leu Thr Phe Ser  Val Lys Thr 
    1190                 1195                 1200             


His Asp  Arg Ile Tyr Tyr Met  Val Ala Pro Ser Pro  Glu Ala Met 
    1205                 1210                 1215             


Arg Ile  Trp Met Asp Val Ile  Val Thr Gly Ala Glu  Gly Tyr Thr 
    1220                 1225                 1230             


His Phe  Leu Leu 
    1235         


<210>  1491
<211>  1253
<212>  PRT
<213>  Homo sapiens

<400>  1491

Met Glu Glu His Ser Tyr Ile Gln Lys Glu Leu Asp Leu Gln Asn Gly 
1               5                   10                  15      


Ser Leu Glu Glu Asp Ser Val Val His Ser Val Glu Asn Asp Ser Gln 
            20                  25                  30          


Asn Met Met Glu Ser Leu Ser Pro Lys Lys Tyr Ser Ser Ser Leu Arg 
        35                  40                  45              


Phe Lys Ala Asn Gly Asp Tyr Ser Gly Ser Tyr Leu Thr Leu Ser Gln 
    50                  55                  60                  


Pro Val Pro Ala Lys Arg Ser Pro Ser Pro Leu Gly Thr Ser Val Arg 
65                  70                  75                  80  


Ser Ser Pro Ser Leu Ala Lys Ile Gln Gly Ser Lys Gln Phe Ser Tyr 
                85                  90                  95      


Asp Gly Thr Asp Lys Asn Ile Pro Met Lys Pro Pro Thr Pro Leu Leu 
            100                 105                 110         


Asn Thr Thr Ser Ser Leu Ser Gly Tyr Pro Leu Gly Arg Ala Asp Phe 
        115                 120                 125             


Asp His Tyr Thr Gly Arg Asp Ser Glu Arg Ala Leu Arg Leu Ser Glu 
    130                 135                 140                 


Lys Pro Pro Tyr Ser Lys Tyr Ser Ser Arg His Lys Ser His Asp Asn 
145                 150                 155                 160 


Val Tyr Ser Leu Gly Gly Leu Glu Gly Arg Lys Ala Ser Gly Ser Leu 
                165                 170                 175     


Leu Ala Met Trp Asn Gly Ser Ser Leu Ser Asp Ala Gly Pro Pro Pro 
            180                 185                 190         


Ile Ser Arg Ser Gly Ala Ala Ser Met Pro Ser Ser Pro Lys Gln Ala 
        195                 200                 205             


Arg Lys Met Ser Ile Gln Asp Ser Leu Ala Leu Gln Pro Lys Leu Thr 
    210                 215                 220                 


Arg His Lys Glu Leu Ala Ser Glu Asn Ile Asn Leu Arg Thr Arg Lys 
225                 230                 235                 240 


Tyr Ser Ser Ser Ser Leu Ser His Met Gly Ala Tyr Ser Arg Ser Leu 
                245                 250                 255     


Pro Arg Leu Tyr Arg Ala Thr Glu Asn Gln Leu Thr Pro Leu Ser Leu 
            260                 265                 270         


Pro Pro Arg Asn Ser Leu Gly Asn Ser Lys Arg Thr Lys Leu Gly Glu 
        275                 280                 285             


Lys Asp Leu Pro His Ser Val Ile Asp Asn Asp Asn Tyr Leu Asn Phe 
    290                 295                 300                 


Ser Ser Leu Ser Ser Gly Ala Leu Pro Tyr Lys Thr Ser Ala Ser Glu 
305                 310                 315                 320 


Gly Asn Pro Tyr Val Ser Ser Thr Leu Ser Val Pro Ala Ser Pro Arg 
                325                 330                 335     


Val Ala Arg Lys Met Leu Leu Ala Ser Thr Ser Ser Cys Ala Ser Asp 
            340                 345                 350         


Asp Phe Asp Gln Ala Ser Tyr Val Gly Thr Asn Pro Ser His Ser Leu 
        355                 360                 365             


Leu Ala Gly Glu Ser Asp Arg Val Phe Ala Thr Arg Arg Asn Phe Ser 
    370                 375                 380                 


Cys Gly Ser Val Glu Phe Asp Glu Ala Asp Leu Glu Ser Leu Arg Gln 
385                 390                 395                 400 


Ala Ser Gly Thr Pro Gln Pro Ala Leu Arg Glu Arg Lys Ser Ser Ile 
                405                 410                 415     


Ser Ser Ile Ser Gly Arg Asp Asp Leu Met Asp Tyr His Arg Arg Gln 
            420                 425                 430         


Arg Glu Glu Arg Leu Arg Glu Gln Glu Met Glu Arg Leu Glu Arg Gln 
        435                 440                 445             


Arg Leu Glu Thr Ile Leu Ser Leu Cys Ala Glu Tyr Thr Lys Pro Asp 
    450                 455                 460                 


Ser Arg Leu Ser Thr Gly Thr Thr Val Glu Asp Val Gln Lys Ile Asn 
465                 470                 475                 480 


Lys Glu Leu Glu Lys Leu Gln Leu Ser Asp Glu Glu Ser Val Phe Glu 
                485                 490                 495     


Glu Ala Leu Met Ser Pro Asp Thr Arg Tyr Arg Cys His Arg Lys Asp 
            500                 505                 510         


Ser Leu Pro Asp Ala Asp Leu Ala Ser Cys Gly Ser Leu Ser Gln Ser 
        515                 520                 525             


Ser Ala Ser Phe Phe Thr Pro Arg Ser Thr Arg Asn Asp Glu Leu Leu 
    530                 535                 540                 


Ser Asp Leu Thr Arg Thr Pro Pro Pro Pro Ser Ser Thr Phe Pro Lys 
545                 550                 555                 560 


Ala Ser Ser Glu Ser Ser Tyr Leu Ser Ile Leu Pro Lys Thr Pro Glu 
                565                 570                 575     


Gly Ile Ser Glu Glu Gln Arg Ser Gln Glu Leu Ala Ala Met Glu Glu 
            580                 585                 590         


Thr Arg Ile Val Ile Leu Asn Asn Leu Glu Glu Leu Lys Gln Lys Ile 
        595                 600                 605             


Lys Asp Ile Asn Asp Gln Met Asp Glu Ser Phe Arg Glu Leu Asp Met 
    610                 615                 620                 


Glu Cys Ala Leu Leu Asp Gly Glu Gln Lys Ser Glu Thr Thr Glu Leu 
625                 630                 635                 640 


Met Lys Glu Lys Glu Ile Leu Asp His Leu Asn Arg Lys Ile Ala Glu 
                645                 650                 655     


Leu Glu Lys Asn Ile Val Gly Glu Lys Thr Lys Glu Lys Val Lys Leu 
            660                 665                 670         


Asp Ala Glu Arg Glu Lys Leu Glu Arg Leu Gln Glu Leu Tyr Ser Glu 
        675                 680                 685             


Gln Lys Thr Gln Leu Asp Asn Cys Pro Glu Ser Met Arg Glu Gln Leu 
    690                 695                 700                 


Gln Gln Gln Leu Lys Arg Asp Ala Asp Leu Leu Asp Val Glu Ser Lys 
705                 710                 715                 720 


His Phe Glu Asp Leu Glu Phe Gln Gln Leu Glu His Glu Ser Arg Leu 
                725                 730                 735     


Asp Glu Glu Lys Glu Asn Leu Thr Gln Gln Leu Leu Arg Glu Val Ala 
            740                 745                 750         


Glu Tyr Gln Arg Asn Ile Val Ser Arg Lys Glu Lys Ile Ser Ala Leu 
        755                 760                 765             


Lys Lys Gln Ala Asn His Ile Val Gln Gln Ala Gln Arg Glu Gln Asp 
    770                 775                 780                 


His Phe Val Lys Glu Lys Asn Asn Leu Ile Met Met Leu Gln Arg Glu 
785                 790                 795                 800 


Lys Glu Asn Leu Cys Asn Leu Glu Lys Lys Tyr Ser Ser Leu Ser Gly 
                805                 810                 815     


Gly Lys Gly Phe Pro Val Asn Pro Asn Thr Leu Lys Glu Gly Tyr Ile 
            820                 825                 830         


Ser Val Asn Glu Ile Asn Glu Pro Cys Gly Asn Ser Thr Asn Leu Ser 
        835                 840                 845             


Pro Ser Thr Gln Phe Pro Ala Asp Ala Asp Ala Val Ala Thr Glu Pro 
    850                 855                 860                 


Ala Thr Ala Val Leu Ala Ser Gln Pro Gln Ser Lys Glu His Phe Arg 
865                 870                 875                 880 


Ser Leu Glu Glu Arg Lys Lys Gln His Lys Glu Gly Leu Tyr Leu Ser 
                885                 890                 895     


Asp Thr Leu Pro Arg Lys Lys Thr Thr Ser Ser Ile Ser Pro His Phe 
            900                 905                 910         


Ser Ser Ala Thr Met Gly Arg Ser Ile Thr Pro Lys Ala His Leu Pro 
        915                 920                 925             


Leu Gly Gln Ser Asn Ser Cys Gly Ser Val Leu Pro Pro Ser Leu Ala 
    930                 935                 940                 


Ala Met Ala Lys Asp Ser Glu Ser Arg Arg Met Leu Arg Gly Tyr Asn 
945                 950                 955                 960 


His Gln Gln Met Ser Glu Gly His Arg Gln Lys Ser Glu Phe Tyr Asn 
                965                 970                 975     


Arg Thr Ala Ser Glu Ser Asn Val Tyr Leu Asn Ser Phe His Tyr Pro 
            980                 985                 990         


Asp His Ser Tyr Lys Asp Gln Ala  Phe Asp Thr Leu Ser  Leu Asp Ser 
        995                 1000                 1005             


Ser Asp  Ser Met Glu Thr Ser  Ile Ser Ala Cys Ser  Pro Asp Asn 
    1010                 1015                 1020             


Ile Ser  Ser Ala Ser Thr Ser  Asn Ile Ala Arg Ile  Glu Glu Met 
    1025                 1030                 1035             


Glu Arg  Leu Leu Lys Gln Ala  His Ala Glu Lys Thr  Arg Leu Leu 
    1040                 1045                 1050             


Glu Ser  Arg Glu Arg Glu Met  Glu Ala Lys Lys Arg  Ala Leu Glu 
    1055                 1060                 1065             


Glu Glu  Lys Arg Arg Arg Glu  Ile Leu Glu Lys Arg  Leu Gln Glu 
    1070                 1075                 1080             


Glu Thr  Ser Gln Arg Gln Lys  Leu Ile Glu Lys Glu  Val Lys Ile 
    1085                 1090                 1095             


Arg Glu  Arg Gln Arg Ala Gln  Ala Arg Pro Leu Thr  Arg Tyr Leu 
    1100                 1105                 1110             


Pro Val  Arg Lys Glu Asp Phe  Asp Leu Arg Ser His  Val Glu Thr 
    1115                 1120                 1125             


Ala Gly  His Asn Ile Asp Thr  Cys Tyr His Val Ser  Ile Thr Glu 
    1130                 1135                 1140             


Lys Thr  Cys Arg Gly Phe Leu  Ile Lys Met Gly Gly  Lys Ile Lys 
    1145                 1150                 1155             


Thr Trp  Lys Lys Arg Trp Phe  Val Phe Asp Arg Asn  Lys Arg Thr 
    1160                 1165                 1170             


Phe Ser  Tyr Tyr Ala Asp Lys  His Glu Thr Lys Leu  Lys Gly Val 
    1175                 1180                 1185             


Ile Tyr  Phe Gln Ala Ile Glu  Glu Val Tyr Tyr Asp  His Leu Lys 
    1190                 1195                 1200             


Asn Ala  Asn Lys Ser Pro Asn  Pro Leu Leu Thr Phe  Ser Val Lys 
    1205                 1210                 1215             


Thr His  Asp Arg Ile Tyr Tyr  Met Val Ala Pro Ser  Pro Glu Ala 
    1220                 1225                 1230             


Met Arg  Ile Trp Met Asp Val  Ile Val Thr Gly Ala  Glu Gly Tyr 
    1235                 1240                 1245             


Thr His  Phe Leu Leu 
    1250             


<210>  1492
<211>  1253
<212>  PRT
<213>  Homo sapiens

<400>  1492

Met Glu Glu His Ser Tyr Ile Gln Lys Glu Leu Asp Leu Gln Asn Gly 
1               5                   10                  15      


Ser Leu Glu Glu Asp Ser Val Val His Ser Val Glu Asn Asp Ser Gln 
            20                  25                  30          


Asn Met Met Glu Ser Leu Ser Pro Lys Lys Tyr Ser Ser Ser Leu Arg 
        35                  40                  45              


Phe Lys Ala Asn Gly Asp Tyr Ser Gly Ser Tyr Leu Thr Leu Ser Gln 
    50                  55                  60                  


Pro Val Pro Ala Lys Arg Ser Pro Ser Pro Leu Gly Thr Ser Val Arg 
65                  70                  75                  80  


Ser Ser Pro Ser Leu Ala Lys Ile Gln Gly Ser Lys Gln Phe Ser Tyr 
                85                  90                  95      


Asp Gly Thr Asp Lys Asn Ile Pro Met Lys Pro Pro Thr Pro Leu Leu 
            100                 105                 110         


Asn Thr Thr Ser Ser Leu Ser Gly Tyr Pro Leu Gly Arg Ala Asp Phe 
        115                 120                 125             


Asp His Tyr Thr Gly Arg Asp Ser Glu Arg Ala Leu Arg Leu Ser Glu 
    130                 135                 140                 


Lys Pro Pro Tyr Ser Lys Tyr Ser Ser Arg His Lys Ser His Asp Asn 
145                 150                 155                 160 


Val Tyr Ser Leu Gly Gly Leu Glu Gly Arg Lys Ala Ser Gly Ser Leu 
                165                 170                 175     


Leu Ala Met Trp Asn Gly Ser Ser Leu Ser Asp Ala Gly Pro Pro Pro 
            180                 185                 190         


Ile Ser Arg Ser Gly Ala Ala Ser Met Pro Ser Ser Pro Lys Gln Ala 
        195                 200                 205             


Arg Lys Met Ser Ile Gln Asp Ser Leu Ala Leu Gln Pro Lys Leu Thr 
    210                 215                 220                 


Arg His Lys Glu Leu Ala Ser Glu Asn Ile Asn Leu Arg Thr Arg Lys 
225                 230                 235                 240 


Tyr Ser Ser Ser Ser Leu Ser His Met Gly Ala Tyr Ser Arg Ser Leu 
                245                 250                 255     


Pro Arg Leu Tyr Arg Ala Thr Glu Asn Gln Leu Thr Pro Leu Ser Leu 
            260                 265                 270         


Pro Pro Arg Asn Ser Leu Gly Asn Ser Lys Arg Thr Lys Leu Gly Glu 
        275                 280                 285             


Lys Asp Leu Pro His Ser Val Ile Asp Asn Asp Asn Tyr Leu Asn Phe 
    290                 295                 300                 


Ser Ser Leu Ser Ser Gly Ala Leu Pro Tyr Lys Thr Ser Ala Ser Glu 
305                 310                 315                 320 


Gly Asn Pro Tyr Val Ser Ser Thr Leu Ser Val Pro Ala Ser Pro Arg 
                325                 330                 335     


Val Ala Arg Lys Met Leu Leu Ala Ser Thr Ser Ser Cys Ala Ser Asp 
            340                 345                 350         


Asp Phe Asp Gln Ala Ser Tyr Val Gly Thr Asn Pro Ser His Ser Leu 
        355                 360                 365             


Leu Ala Gly Glu Ser Asp Arg Val Phe Ala Thr Arg Arg Asn Phe Ser 
    370                 375                 380                 


Cys Gly Ser Val Glu Phe Asp Glu Ala Asp Leu Glu Ser Leu Arg Gln 
385                 390                 395                 400 


Ala Ser Gly Thr Pro Gln Pro Ala Leu Arg Glu Arg Lys Ser Ser Ile 
                405                 410                 415     


Ser Ser Ile Ser Gly Arg Asp Asp Leu Met Asp Tyr His Arg Arg Gln 
            420                 425                 430         


Arg Glu Glu Arg Leu Arg Glu Gln Glu Met Glu Arg Leu Glu Arg Gln 
        435                 440                 445             


Arg Leu Glu Thr Ile Leu Ser Leu Cys Ala Glu Tyr Thr Lys Pro Asp 
    450                 455                 460                 


Ser Arg Leu Ser Thr Gly Thr Thr Val Glu Asp Val Gln Lys Ile Asn 
465                 470                 475                 480 


Lys Glu Leu Glu Lys Leu Gln Leu Ser Asp Glu Glu Ser Val Phe Glu 
                485                 490                 495     


Glu Ala Leu Met Ser Pro Asp Thr Arg Tyr Arg Cys His Arg Lys Asp 
            500                 505                 510         


Ser Leu Pro Asp Ala Asp Leu Ala Ser Cys Gly Ser Leu Ser Gln Ser 
        515                 520                 525             


Ser Ala Ser Phe Phe Thr Pro Arg Ser Thr Arg Asn Asp Glu Leu Leu 
    530                 535                 540                 


Ser Asp Leu Thr Arg Thr Pro Pro Pro Pro Ser Ser Thr Phe Pro Lys 
545                 550                 555                 560 


Ala Ser Ser Glu Ser Ser Tyr Leu Ser Ile Leu Pro Lys Thr Pro Glu 
                565                 570                 575     


Gly Ile Ser Glu Glu Gln Arg Ser Gln Glu Leu Ala Ala Met Glu Glu 
            580                 585                 590         


Thr Arg Ile Val Ile Leu Asn Asn Leu Glu Glu Leu Lys Gln Lys Ile 
        595                 600                 605             


Lys Asp Ile Asn Asp Gln Met Asp Glu Ser Phe Arg Glu Leu Asp Met 
    610                 615                 620                 


Glu Cys Ala Leu Leu Asp Gly Glu Gln Lys Ser Glu Thr Thr Glu Leu 
625                 630                 635                 640 


Met Lys Glu Lys Glu Ile Leu Asp His Leu Asn Arg Lys Ile Ala Glu 
                645                 650                 655     


Leu Glu Lys Asn Ile Val Gly Glu Lys Thr Lys Glu Lys Val Lys Leu 
            660                 665                 670         


Asp Ala Glu Arg Glu Lys Leu Glu Arg Leu Gln Glu Leu Tyr Ser Glu 
        675                 680                 685             


Gln Lys Thr Gln Leu Asp Asn Cys Pro Glu Ser Met Arg Glu Gln Leu 
    690                 695                 700                 


Gln Gln Gln Leu Lys Arg Asp Ala Asp Leu Leu Asp Val Glu Ser Lys 
705                 710                 715                 720 


His Phe Glu Asp Leu Glu Phe Gln Gln Leu Glu His Glu Ser Arg Leu 
                725                 730                 735     


Asp Glu Glu Lys Glu Asn Leu Thr Gln Gln Leu Leu Arg Glu Val Ala 
            740                 745                 750         


Glu Tyr Gln Arg Asn Ile Val Ser Arg Lys Glu Lys Ile Ser Ala Leu 
        755                 760                 765             


Lys Lys Gln Ala Asn His Ile Val Gln Gln Ala Gln Arg Glu Gln Asp 
    770                 775                 780                 


His Phe Val Lys Glu Lys Asn Asn Leu Ile Met Met Leu Gln Arg Glu 
785                 790                 795                 800 


Lys Glu Asn Leu Cys Asn Leu Glu Lys Lys Tyr Ser Ser Leu Ser Gly 
                805                 810                 815     


Gly Lys Gly Phe Pro Val Asn Pro Asn Thr Leu Lys Glu Gly Tyr Ile 
            820                 825                 830         


Ser Val Asn Glu Ile Asn Glu Pro Cys Gly Asn Ser Thr Asn Leu Ser 
        835                 840                 845             


Pro Ser Thr Gln Phe Pro Ala Asp Ala Asp Ala Val Ala Thr Glu Pro 
    850                 855                 860                 


Ala Thr Ala Val Leu Ala Ser Gln Pro Gln Ser Lys Glu His Phe Arg 
865                 870                 875                 880 


Ser Leu Glu Glu Arg Lys Lys Gln His Lys Glu Gly Leu Tyr Leu Ser 
                885                 890                 895     


Asp Thr Leu Pro Arg Lys Lys Thr Thr Ser Ser Ile Ser Pro His Phe 
            900                 905                 910         


Ser Ser Ala Thr Met Gly Arg Ser Ile Thr Pro Lys Ala His Leu Pro 
        915                 920                 925             


Leu Gly Gln Ser Asn Ser Cys Gly Ser Val Leu Pro Pro Ser Leu Ala 
    930                 935                 940                 


Ala Met Ala Lys Asp Ser Glu Ser Arg Arg Met Leu Arg Gly Tyr Asn 
945                 950                 955                 960 


His Gln Gln Met Ser Glu Gly His Arg Gln Lys Ser Glu Phe Tyr Asn 
                965                 970                 975     


Arg Thr Ala Ser Glu Ser Asn Val Tyr Leu Asn Ser Phe His Tyr Pro 
            980                 985                 990         


Asp His Ser Tyr Lys Asp Gln Ala  Phe Asp Thr Leu Ser  Leu Asp Ser 
        995                 1000                 1005             


Ser Asp  Ser Met Glu Thr Ser  Ile Ser Ala Cys Ser  Pro Asp Asn 
    1010                 1015                 1020             


Ile Ser  Ser Ala Ser Thr Ser  Asn Ile Ala Arg Ile  Glu Glu Met 
    1025                 1030                 1035             


Glu Arg  Leu Leu Lys Gln Ala  His Ala Glu Lys Thr  Arg Leu Leu 
    1040                 1045                 1050             


Glu Ser  Arg Glu Arg Glu Met  Glu Ala Lys Lys Arg  Ala Leu Glu 
    1055                 1060                 1065             


Glu Glu  Lys Arg Arg Arg Glu  Ile Leu Glu Lys Arg  Leu Gln Glu 
    1070                 1075                 1080             


Glu Thr  Ser Gln Arg Gln Lys  Leu Ile Glu Lys Glu  Val Lys Ile 
    1085                 1090                 1095             


Arg Glu  Arg Gln Arg Ala Gln  Ala Arg Pro Leu Thr  Arg Tyr Leu 
    1100                 1105                 1110             


Pro Val  Arg Lys Glu Asp Phe  Asp Leu Arg Ser His  Val Glu Thr 
    1115                 1120                 1125             


Ala Gly  His Asn Ile Asp Thr  Cys Tyr His Val Ser  Ile Thr Glu 
    1130                 1135                 1140             


Lys Thr  Cys Arg Gly Phe Leu  Ile Lys Met Gly Gly  Lys Ile Lys 
    1145                 1150                 1155             


Thr Trp  Lys Lys Arg Trp Phe  Val Phe Asp Arg Asn  Lys Arg Thr 
    1160                 1165                 1170             


Phe Ser  Tyr Tyr Ala Asp Lys  His Glu Thr Lys Leu  Lys Gly Val 
    1175                 1180                 1185             


Ile Tyr  Phe Gln Ala Ile Glu  Glu Val Tyr Tyr Asp  His Leu Lys 
    1190                 1195                 1200             


Asn Ala  Asn Lys Ser Pro Asn  Pro Leu Leu Thr Phe  Ser Val Lys 
    1205                 1210                 1215             


Thr His  Asp Arg Ile Tyr Tyr  Met Val Ala Pro Ser  Pro Glu Ala 
    1220                 1225                 1230             


Met Arg  Ile Trp Met Asp Val  Ile Val Thr Gly Ala  Glu Gly Tyr 
    1235                 1240                 1245             


Thr His  Phe Leu Leu 
    1250             


<210>  1493
<211>  435
<212>  PRT
<213>  Homo sapiens

<400>  1493

Met Ala Gln Ala Val Trp Ser Arg Leu Gly Arg Ile Leu Trp Leu Ala 
1               5                   10                  15      


Cys Leu Leu Pro Trp Ala Pro Ala Gly Val Ala Ala Gly Leu Tyr Glu 
            20                  25                  30          


Leu Asn Leu Thr Thr Asp Ser Pro Ala Thr Thr Gly Ala Val Val Thr 
        35                  40                  45              


Ile Ser Ala Ser Leu Val Ala Lys Asp Asn Gly Ser Leu Ala Leu Pro 
    50                  55                  60                  


Ala Asp Ala His Leu Tyr Arg Phe His Trp Ile His Thr Pro Leu Val 
65                  70                  75                  80  


Leu Thr Gly Lys Met Glu Lys Gly Leu Ser Ser Thr Ile Arg Val Val 
                85                  90                  95      


Gly His Val Pro Gly Glu Phe Pro Val Ser Val Trp Val Thr Ala Ala 
            100                 105                 110         


Asp Cys Trp Met Cys Gln Pro Val Ala Arg Gly Phe Val Val Leu Pro 
        115                 120                 125             


Ile Thr Glu Phe Leu Val Gly Asp Leu Val Val Thr Gln Asn Thr Ser 
    130                 135                 140                 


Leu Pro Trp Pro Ser Ser Tyr Leu Thr Lys Thr Val Leu Lys Val Ser 
145                 150                 155                 160 


Phe Leu Leu His Asp Pro Ser Asn Phe Leu Lys Thr Ala Leu Phe Leu 
                165                 170                 175     


Tyr Ser Trp Asp Phe Gly Asp Gly Thr Gln Met Val Thr Glu Asp Ser 
            180                 185                 190         


Val Val Tyr Tyr Asn Tyr Ser Ile Ile Gly Thr Phe Thr Val Lys Leu 
        195                 200                 205             


Lys Val Val Ala Glu Trp Glu Glu Val Glu Pro Asp Ala Thr Arg Ala 
    210                 215                 220                 


Val Lys Gln Lys Thr Gly Asp Phe Ser Ala Ser Leu Lys Leu Gln Glu 
225                 230                 235                 240 


Thr Leu Arg Gly Ile Gln Val Leu Gly Pro Thr Leu Ile Gln Thr Phe 
                245                 250                 255     


Gln Lys Met Thr Val Thr Leu Asn Phe Leu Gly Ser Pro Pro Leu Thr 
            260                 265                 270         


Val Cys Trp Arg Leu Lys Pro Glu Cys Leu Pro Leu Glu Glu Gly Glu 
        275                 280                 285             


Cys His Pro Val Ser Val Ala Ser Thr Ala Tyr Asn Leu Thr His Thr 
    290                 295                 300                 


Phe Arg Asp Pro Gly Asp Tyr Cys Phe Ser Ile Arg Ala Glu Asn Ile 
305                 310                 315                 320 


Ile Ser Lys Thr His Gln Tyr His Lys Ile Gln Val Trp Pro Ser Arg 
                325                 330                 335     


Ile Gln Pro Ala Val Phe Ala Phe Pro Cys Ala Thr Leu Ile Thr Val 
            340                 345                 350         


Met Leu Ala Phe Ile Met Tyr Met Thr Leu Arg Asn Ala Thr Gln Gln 
        355                 360                 365             


Lys Asp Met Val Glu Val Ala Asp Phe Asp Phe Ser Pro Met Ser Asp 
    370                 375                 380                 


Lys Asn Pro Glu Pro Pro Ser Gly Val Arg Cys Cys Cys Gln Met Cys 
385                 390                 395                 400 


Cys Gly Pro Phe Leu Leu Glu Thr Pro Ser Glu Tyr Leu Glu Ile Val 
                405                 410                 415     


Arg Glu Asn His Gly Leu Leu Pro Pro Leu Tyr Lys Ser Val Lys Thr 
            420                 425                 430         


Tyr Thr Val 
        435 


<210>  1494
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  1494

Met Ala Gln Ala Val Trp Ser Arg Leu Gly Arg Ile Leu Trp Leu Ala 
1               5                   10                  15      


Cys Leu Leu Pro Trp Ala Pro Ala Gly Val Ala Ala Glu Phe Leu Val 
            20                  25                  30          


Gly Asp Leu Val Val Thr Gln Asn Thr Ser Leu Pro Trp Pro Ser Ser 
        35                  40                  45              


Tyr Leu Thr Lys Thr Val Leu Lys Val Ser Phe Leu Leu His Asp Pro 
    50                  55                  60                  


Ser Asn Phe Leu Lys Thr Ala Leu Phe Leu Tyr Ser Trp Asp Phe Gly 
65                  70                  75                  80  


Asp Gly Thr Gln Met Val Thr Glu Asp Ser Val Val Tyr Tyr Asn Tyr 
                85                  90                  95      


Ser Ile Ile Gly Thr Phe Thr Val Lys Leu Lys Val Val Ala Glu Trp 
            100                 105                 110         


Glu Glu Val Glu Pro Asp Ala Thr Arg Ala Val Lys Gln Lys Thr Gly 
        115                 120                 125             


Asp Phe Ser Ala Ser Leu Lys Leu Gln Glu Thr Leu Arg Gly Ile Gln 
    130                 135                 140                 


Val Leu Gly Pro Thr Leu Ile Gln Thr Phe Gln Lys Met Thr Val Thr 
145                 150                 155                 160 


Leu Asn Phe Leu Gly Ser Pro Pro Leu Thr Val Cys Trp Arg Leu Lys 
                165                 170                 175     


Pro Glu Cys Leu Pro Leu Glu Glu Gly Glu Cys His Pro Val Ser Val 
            180                 185                 190         


Ala Ser Thr Ala Tyr Asn Leu Thr His Thr Phe Arg Asp Pro Gly Asp 
        195                 200                 205             


Tyr Cys Phe Ser Ile Arg Ala Glu Asn Ile Ile Ser Lys Thr His Gln 
    210                 215                 220                 


Tyr His Lys Ile Gln Val Trp Pro Ser Arg Ile Gln Pro Ala Val Phe 
225                 230                 235                 240 


Ala Phe Pro Cys Ala Thr Leu Ile Thr Val Met Leu Ala Phe Ile Met 
                245                 250                 255     


Tyr Met Thr Leu Arg Asn Ala Thr Gln Gln Lys Asp Met Val Glu Asn 
            260                 265                 270         


Pro Glu Pro Pro Ser Gly Val Arg Cys Cys Cys Gln Met Cys Cys Gly 
        275                 280                 285             


Pro Phe Leu Leu Glu Thr Pro Ser Glu Tyr Leu Glu Ile Val Arg Glu 
    290                 295                 300                 


Asn His Gly Leu Leu Pro Pro Leu Tyr Lys Ser Val Lys Thr Tyr Thr 
305                 310                 315                 320 


Val 
    


<210>  1495
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  1495

Met Trp Thr Asn Phe Phe Lys Leu Arg Leu Phe Cys Cys Leu Leu Ala 
1               5                   10                  15      


Val Leu Met Val Val Val Leu Val Ile Asn Val Thr Gln Val Glu Tyr 
            20                  25                  30          


Leu Asp His Glu Thr Val Ser Ala Thr Phe Ile Asp Ser Ser Gly Gln 
        35                  40                  45              


Phe Val Ser Ser Gln Val Thr Gly Ile Ser Arg Asn Pro Tyr Cys Gly 
    50                  55                  60                  


Tyr Asp Gln Gln Thr Leu Ser Ser Gln Glu Arg Met Glu Glu Asp Ser 
65                  70                  75                  80  


Leu Leu Ala Ala Leu His Arg Gln Val Pro Asp Val Gly Pro Val Pro 
                85                  90                  95      


Phe Val Lys Ser Thr Asp Pro Ser Ser Ser Tyr Phe Val Ile Leu Asn 
            100                 105                 110         


Ser Ala Ala Phe Phe Lys Val Gly Ser Gln Leu Glu Val Leu Val His 
        115                 120                 125             


Val Gln Asp Phe Gln Arg Lys Pro Lys Lys Tyr Gly Gly Asp Tyr Leu 
    130                 135                 140                 


Gln Ala Arg Ile His Ser Leu Lys Leu Gln Ala Gly Ala Val Gly Arg 
145                 150                 155                 160 


Val Val Asp Tyr Gln Asn Gly Phe Tyr Lys Val Phe Phe Thr Leu Leu 
                165                 170                 175     


Trp Pro Gly Lys Val Lys Val Ser Val Ser Leu Val His Pro Ser Glu 
            180                 185                 190         


Gly Ile Arg Val Leu Gln Arg Leu Gln Glu Asp Lys Pro Asp Arg Val 
        195                 200                 205             


Tyr Phe Lys Ser Leu Phe Arg Ser Gly Arg Ile Ser Glu Thr Thr Glu 
    210                 215                 220                 


Cys Asn Val Cys Leu Pro Gly Asn Leu Pro Leu Cys Asn Phe Thr Asp 
225                 230                 235                 240 


Leu Tyr Thr Gly Glu Pro Trp Phe Cys Phe Lys Pro Lys Lys Leu Pro 
                245                 250                 255     


Cys Ser Ser Arg Ile Thr His Phe Lys Gly Gly Tyr Leu Lys Gly Leu 
            260                 265                 270         


Leu Thr Ala Ala Glu Ser Ala Phe Phe Gln Ser Gly Val Asn Ile Lys 
        275                 280                 285             


Met Pro Val Asn Ser Ser Gly Pro Asp Trp Val Thr Val Ile Pro Arg 
    290                 295                 300                 


Arg Ile Lys Glu Thr Asn Ser Leu Glu Leu Ser Gln Gly Ser Gly Thr 
305                 310                 315                 320 


Phe Pro Ser Gly Tyr Tyr Tyr Lys Asp Gln Trp Arg Pro Arg Lys Phe 
                325                 330                 335     


Lys Met Arg Gln Phe Asn Asp Pro Asp Asn Ile Thr Glu Cys Leu Gln 
            340                 345                 350         


Arg Lys Val Val His Leu Phe Gly Asp Ser Thr Ile Arg Gln Trp Phe 
        355                 360                 365             


Glu Tyr Leu Thr Thr Phe Val Pro Asp Leu Val Glu Phe Asn Leu Gly 
    370                 375                 380                 


Ser Pro Lys Asn Val Gly Pro Phe Leu Ala Val Asp Gln Lys His Asn 
385                 390                 395                 400 


Ile Leu Leu Lys Tyr Arg Cys His Gly Pro Pro Ile Arg Phe Thr Thr 
                405                 410                 415     


Val Phe Ser Asn Glu Leu His Tyr Val Ala Asn Glu Leu Asn Gly Ile 
            420                 425                 430         


Val Gly Gly Lys Asn Thr Val Val Ala Ile Ala Val Trp Ser His Phe 
        435                 440                 445             


Ser Thr Phe Pro Leu Glu Val Tyr Ile Arg Arg Leu Arg Asn Ile Arg 
    450                 455                 460                 


Arg Ala Val Val Arg Leu Leu Asp Arg Ser Pro Lys Thr Val Val Val 
465                 470                 475                 480 


Ile Arg Thr Ala Asn Ala Gln Glu Leu Gly Pro Glu Val Ser Leu Phe 
                485                 490                 495     


Asn Ser Asp Trp Tyr Asn Phe Gln Leu Asp Thr Ile Leu Arg Arg Met 
            500                 505                 510         


Phe Ser Gly Val Gly Val Tyr Leu Val Asp Ala Trp Glu Met Thr Leu 
        515                 520                 525             


Ala His Tyr Leu Pro His Lys Leu His Pro Asp Glu Val Ile Val Lys 
    530                 535                 540                 


Asn Gln Leu Asp Met Phe Leu Ser Phe Val Cys Pro Leu Glu Thr 
545                 550                 555                 


<210>  1496
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  1496

Met Thr His Ser Ser Gln Asp Thr Gly Ser Cys Gly Ile Gln Glu Asp 
1               5                   10                  15      


Gly Lys Leu Tyr Val Val Asp Ser Ile Asn Asp Leu Asn Lys Leu Asn 
            20                  25                  30          


Leu Cys Pro Ala Gly Ser Gln His Leu Phe Pro Leu Glu Asp Lys Ile 
        35                  40                  45              


Pro Val Leu Gly Thr Asn Ser Gly Asn Gly Ser Arg Ser Leu Phe Phe 
    50                  55                  60                  


Val Gly Leu Leu Ile Val Leu Ile Val Ser Leu Ala Leu Val Phe Phe 
65                  70                  75                  80  


Val Ile Phe Leu Ile Val Gln Thr Gly Asn Lys Met Asp Asp Val Ser 
                85                  90                  95      


Arg Arg Leu Thr Ala Glu Gly Lys Asp Ile Asp Asp Leu Lys Arg Ile 
            100                 105                 110         


Asn Asn Met Ile Val Lys Arg Leu Asn Gln Leu Asn Gln Leu Asp Ser 
        115                 120                 125             


Glu Gln Asn 
    130     


<210>  1497
<211>  803
<212>  PRT
<213>  Homo sapiens

<400>  1497

Met Ile Thr Leu Thr Glu Leu Lys Cys Leu Ala Asp Ala Gln Ser Ser 
1               5                   10                  15      


Tyr His Ile Leu Lys Pro Trp Trp Asp Val Phe Trp Tyr Tyr Ile Thr 
            20                  25                  30          


Leu Ile Met Leu Leu Val Ala Val Leu Ala Gly Ala Leu Gln Leu Thr 
        35                  40                  45              


Gln Ser Arg Val Leu Cys Cys Leu Pro Cys Lys Val Glu Phe Asp Asn 
    50                  55                  60                  


His Cys Ala Val Pro Trp Asp Ile Leu Lys Ala Ser Met Asn Thr Ser 
65                  70                  75                  80  


Ser Asn Pro Gly Thr Pro Leu Pro Leu Pro Leu Arg Ile Gln Asn Asp 
                85                  90                  95      


Leu His Arg Gln Gln Tyr Ser Tyr Ile Asp Ala Val Cys Tyr Glu Lys 
            100                 105                 110         


Gln Leu His Trp Phe Ala Lys Phe Phe Pro Tyr Leu Val Leu Leu His 
        115                 120                 125             


Thr Leu Ile Phe Ala Ala Cys Ser Asn Phe Trp Leu His Tyr Pro Ser 
    130                 135                 140                 


Thr Ser Ser Arg Leu Glu His Phe Val Ala Ile Leu His Lys Cys Phe 
145                 150                 155                 160 


Asp Ser Pro Trp Thr Thr Arg Ala Leu Ser Glu Thr Val Ala Glu Gln 
                165                 170                 175     


Ser Val Arg Pro Leu Lys Leu Ser Lys Ser Lys Ile Leu Leu Ser Ser 
            180                 185                 190         


Ser Gly Cys Ser Ala Asp Ile Asp Ser Gly Lys Gln Ser Leu Pro Tyr 
        195                 200                 205             


Pro Gln Pro Gly Leu Glu Ser Ala Gly Ile Glu Ser Pro Thr Ser Ser 
    210                 215                 220                 


Val Leu Asp Lys Lys Glu Gly Glu Gln Ala Lys Ala Ile Phe Glu Lys 
225                 230                 235                 240 


Val Lys Arg Phe Arg Met His Val Glu Gln Lys Asp Ile Ile Tyr Arg 
                245                 250                 255     


Val Tyr Leu Lys Gln Ile Ile Val Lys Val Ile Leu Phe Val Leu Ile 
            260                 265                 270         


Ile Thr Tyr Val Pro Tyr Phe Leu Thr His Ile Thr Leu Glu Ile Asp 
        275                 280                 285             


Cys Ser Val Asp Val Gln Ala Phe Thr Gly Tyr Lys Arg Tyr Gln Cys 
    290                 295                 300                 


Val Tyr Ser Leu Ala Glu Ile Phe Lys Val Leu Ala Ser Phe Tyr Val 
305                 310                 315                 320 


Ile Leu Val Ile Leu Tyr Gly Leu Thr Ser Ser Tyr Ser Leu Trp Trp 
                325                 330                 335     


Met Leu Arg Ser Ser Leu Lys Gln Tyr Ser Phe Glu Ala Leu Arg Glu 
            340                 345                 350         


Lys Ser Asn Tyr Ser Asp Ile Pro Asp Val Lys Asn Asp Phe Ala Phe 
        355                 360                 365             


Ile Leu His Leu Ala Asp Gln Tyr Asp Pro Leu Tyr Ser Lys Arg Phe 
    370                 375                 380                 


Ser Ile Phe Leu Ser Glu Val Ser Glu Asn Lys Leu Lys Gln Ile Asn 
385                 390                 395                 400 


Leu Asn Asn Glu Trp Thr Val Glu Lys Leu Lys Ser Lys Leu Val Lys 
                405                 410                 415     


Asn Ala Gln Asp Lys Ile Glu Leu His Leu Phe Met Leu Asn Gly Leu 
            420                 425                 430         


Pro Asp Asn Val Phe Glu Leu Thr Glu Met Glu Val Leu Ser Leu Glu 
        435                 440                 445             


Leu Ile Pro Glu Val Lys Leu Pro Ser Ala Val Ser Gln Leu Val Asn 
    450                 455                 460                 


Leu Lys Glu Leu Arg Val Tyr His Ser Ser Leu Val Val Asp His Pro 
465                 470                 475                 480 


Ala Leu Ala Phe Leu Glu Glu Asn Leu Lys Ile Leu Arg Leu Lys Phe 
                485                 490                 495     


Thr Glu Met Gly Lys Ile Pro Arg Trp Val Phe His Leu Lys Asn Leu 
            500                 505                 510         


Lys Glu Leu Tyr Leu Ser Gly Cys Val Leu Pro Glu Gln Leu Ser Thr 
        515                 520                 525             


Met Gln Leu Glu Gly Phe Gln Asp Leu Lys Asn Leu Arg Thr Leu Tyr 
    530                 535                 540                 


Leu Lys Ser Ser Leu Ser Arg Ile Pro Gln Val Val Thr Asp Leu Leu 
545                 550                 555                 560 


Pro Ser Leu Gln Lys Leu Ser Leu Asp Asn Glu Gly Ser Lys Leu Val 
                565                 570                 575     


Val Leu Asn Asn Leu Lys Lys Met Val Asn Leu Lys Ser Leu Glu Leu 
            580                 585                 590         


Ile Ser Cys Asp Leu Glu Arg Ile Pro His Ser Ile Phe Ser Leu Asn 
        595                 600                 605             


Asn Leu His Glu Leu Asp Leu Arg Glu Asn Asn Leu Lys Thr Val Glu 
    610                 615                 620                 


Glu Ile Ile Ser Phe Gln His Leu Gln Asn Leu Ser Cys Leu Lys Leu 
625                 630                 635                 640 


Trp His Asn Asn Ile Ala Tyr Ile Pro Ala Gln Ile Gly Ala Leu Ser 
                645                 650                 655     


Asn Leu Glu Gln Leu Ser Leu Asp His Asn Asn Ile Glu Asn Leu Pro 
            660                 665                 670         


Leu Gln Leu Phe Leu Cys Thr Lys Leu His Tyr Leu Asp Leu Ser Tyr 
        675                 680                 685             


Asn His Leu Thr Phe Ile Pro Glu Glu Ile Gln Tyr Leu Ser Asn Leu 
    690                 695                 700                 


Gln Tyr Phe Ala Val Thr Asn Asn Asn Ile Glu Met Leu Pro Asp Gly 
705                 710                 715                 720 


Leu Phe Gln Cys Lys Lys Leu Gln Cys Leu Leu Leu Gly Lys Asn Ser 
                725                 730                 735     


Leu Met Asn Leu Ser Pro His Val Gly Glu Leu Ser Asn Leu Thr His 
            740                 745                 750         


Leu Glu Leu Ile Gly Asn Tyr Leu Glu Thr Leu Pro Pro Glu Leu Glu 
        755                 760                 765             


Gly Cys Gln Ser Leu Lys Arg Asn Cys Leu Ile Val Glu Glu Asn Leu 
    770                 775                 780                 


Leu Asn Thr Leu Pro Leu Pro Val Thr Glu Arg Leu Gln Thr Cys Leu 
785                 790                 795                 800 


Asp Lys Cys 
            


<210>  1498
<211>  1237
<212>  PRT
<213>  Homo sapiens

<400>  1498

Met Glu Glu Glu Asp Thr Lys Arg Glu Val Pro Lys Glu Asp Gly Val 
1               5                   10                  15      


Gly Asp Val Gln His Phe Asp Ser Ser Lys Ile Met Glu Glu His Ser 
            20                  25                  30          


Tyr Ile Gln Lys Glu Leu Asp Leu Gln Asn Gly Ser Leu Glu Glu Asp 
        35                  40                  45              


Ser Val Val His Ser Val Glu Asn Asp Ser Gln Asn Met Met Glu Ser 
    50                  55                  60                  


Leu Ser Pro Lys Lys Tyr Ser Ser Ser Leu Arg Phe Lys Ala Asn Gly 
65                  70                  75                  80  


Asp Tyr Ser Gly Ser Tyr Leu Thr Leu Ser Gln Pro Val Pro Ala Lys 
                85                  90                  95      


Arg Ser Pro Ser Pro Leu Gly Thr Ser Val Arg Ser Ser Pro Ser Leu 
            100                 105                 110         


Ala Lys Ile Gln Gly Ser Lys Gln Phe Ser Tyr Asp Gly Thr Asp Lys 
        115                 120                 125             


Asn Ile Pro Met Lys Pro Pro Thr Pro Leu Leu Asn Thr Thr Ser Ser 
    130                 135                 140                 


Leu Ser Gly Tyr Pro Leu Gly Arg Ala Asp Phe Asp His Tyr Thr Gly 
145                 150                 155                 160 


Arg Asp Ser Glu Arg Ala Leu Arg Leu Ser Glu Lys Pro Pro Tyr Ser 
                165                 170                 175     


Lys Tyr Ser Ser Arg His Lys Ser His Asp Asn Val Tyr Ser Leu Gly 
            180                 185                 190         


Gly Leu Glu Gly Arg Lys Ala Ser Gly Ser Leu Leu Ala Met Trp Asn 
        195                 200                 205             


Gly Ser Ser Leu Ser Asp Ala Gly Pro Pro Pro Ile Ser Arg Ser Gly 
    210                 215                 220                 


Ala Ala Ser Met Pro Ser Ser Pro Lys Gln Ala Arg Lys Met Ser Ile 
225                 230                 235                 240 


Gln Asp Ser Leu Ala Leu Gln Pro Lys Leu Thr Arg His Lys Glu Leu 
                245                 250                 255     


Ala Ser Glu Asn Ile Asn Leu Arg Thr Arg Lys Tyr Ser Ser Ser Ser 
            260                 265                 270         


Leu Ser His Met Gly Ala Tyr Ser Arg Ser Leu Pro Arg Leu Tyr Arg 
        275                 280                 285             


Ala Thr Glu Asn Gln Leu Thr Pro Leu Ser Leu Pro Pro Arg Asn Ser 
    290                 295                 300                 


Leu Gly Asn Ser Lys Arg Thr Lys Leu Gly Glu Lys Asp Leu Pro His 
305                 310                 315                 320 


Ser Val Ile Asp Asn Asp Asn Tyr Leu Asn Phe Ser Ser Leu Ser Ser 
                325                 330                 335     


Gly Ala Leu Pro Tyr Lys Thr Ser Ala Ser Glu Gly Asn Pro Tyr Val 
            340                 345                 350         


Ser Ser Thr Leu Ser Val Pro Ala Ser Pro Arg Val Ala Arg Lys Met 
        355                 360                 365             


Leu Leu Ala Ser Thr Ser Ser Cys Ala Ser Asp Asp Phe Asp Gln Ala 
    370                 375                 380                 


Ser Tyr Val Gly Thr Asn Pro Ser His Ser Leu Leu Ala Gly Glu Ser 
385                 390                 395                 400 


Asp Arg Val Phe Ala Thr Arg Arg Asn Phe Ser Cys Gly Ser Val Glu 
                405                 410                 415     


Phe Asp Glu Ala Asp Leu Glu Ser Leu Arg Gln Ala Ser Gly Thr Pro 
            420                 425                 430         


Gln Pro Ala Leu Arg Glu Arg Lys Ser Ser Ile Ser Ser Ile Ser Gly 
        435                 440                 445             


Arg Asp Asp Leu Met Asp Tyr His Arg Arg Gln Arg Glu Glu Arg Leu 
    450                 455                 460                 


Arg Glu Gln Glu Met Glu Arg Leu Glu Arg Gln Arg Leu Glu Thr Ile 
465                 470                 475                 480 


Leu Ser Leu Cys Ala Glu Tyr Thr Lys Pro Asp Ser Arg Leu Ser Thr 
                485                 490                 495     


Gly Thr Thr Val Glu Asp Val Gln Lys Ile Asn Lys Glu Leu Glu Lys 
            500                 505                 510         


Leu Gln Leu Ser Asp Glu Glu Ser Val Phe Glu Glu Ala Leu Met Ser 
        515                 520                 525             


Pro Asp Thr Arg Tyr Arg Cys His Arg Lys Asp Ser Leu Pro Asp Ala 
    530                 535                 540                 


Asp Leu Ala Ser Cys Gly Ser Leu Ser Gln Ser Ser Ala Ser Phe Phe 
545                 550                 555                 560 


Thr Pro Arg Ser Thr Arg Asn Asp Glu Leu Leu Ser Asp Leu Thr Arg 
                565                 570                 575     


Thr Pro Pro Pro Pro Ser Ser Thr Phe Pro Lys Ala Ser Ser Glu Ser 
            580                 585                 590         


Ser Tyr Leu Ser Ile Leu Pro Lys Thr Pro Glu Gly Ile Ser Glu Glu 
        595                 600                 605             


Gln Arg Ser Gln Glu Leu Ala Ala Met Glu Glu Thr Arg Ile Val Ile 
    610                 615                 620                 


Leu Asn Asn Leu Glu Glu Leu Lys Gln Lys Ile Lys Asp Ile Asn Asp 
625                 630                 635                 640 


Gln Met Asp Glu Ser Phe Arg Glu Leu Asp Met Glu Cys Ala Leu Leu 
                645                 650                 655     


Asp Gly Glu Gln Lys Ser Glu Thr Thr Glu Leu Met Lys Glu Lys Glu 
            660                 665                 670         


Ile Leu Asp His Leu Asn Arg Lys Ile Ala Glu Leu Glu Lys Asn Ile 
        675                 680                 685             


Val Gly Glu Lys Thr Lys Asp Ala Asp Leu Leu Asp Val Glu Ser Lys 
    690                 695                 700                 


His Phe Glu Asp Leu Glu Phe Gln Gln Leu Glu His Glu Ser Arg Leu 
705                 710                 715                 720 


Asp Glu Glu Lys Glu Asn Leu Thr Gln Gln Leu Leu Arg Glu Val Ala 
                725                 730                 735     


Glu Tyr Gln Arg Asn Ile Val Ser Arg Lys Glu Lys Ile Ser Ala Leu 
            740                 745                 750         


Lys Lys Gln Ala Asn His Ile Val Gln Gln Ala Gln Arg Glu Gln Asp 
        755                 760                 765             


His Phe Val Lys Glu Lys Asn Asn Leu Ile Met Met Leu Gln Arg Glu 
    770                 775                 780                 


Lys Glu Asn Leu Cys Asn Leu Glu Lys Lys Tyr Ser Ser Leu Ser Gly 
785                 790                 795                 800 


Gly Lys Gly Phe Pro Val Asn Pro Asn Thr Leu Lys Glu Gly Tyr Ile 
                805                 810                 815     


Ser Val Asn Glu Ile Asn Glu Pro Cys Gly Asn Ser Thr Asn Leu Ser 
            820                 825                 830         


Pro Ser Thr Gln Phe Pro Ala Asp Ala Asp Ala Val Ala Thr Glu Pro 
        835                 840                 845             


Ala Thr Ala Val Leu Ala Ser Gln Pro Gln Ser Lys Glu His Phe Arg 
    850                 855                 860                 


Ser Leu Glu Glu Arg Lys Lys Gln His Lys Glu Gly Leu Tyr Leu Ser 
865                 870                 875                 880 


Asp Thr Leu Pro Arg Lys Lys Thr Thr Ser Ser Ile Ser Pro His Phe 
                885                 890                 895     


Ser Ser Ala Thr Met Gly Arg Ser Ile Thr Pro Lys Ala His Leu Pro 
            900                 905                 910         


Leu Gly Gln Ser Asn Ser Cys Gly Ser Val Leu Pro Pro Ser Leu Ala 
        915                 920                 925             


Ala Met Ala Lys Asp Ser Glu Ser Arg Arg Met Leu Arg Gly Tyr Asn 
    930                 935                 940                 


His Gln Gln Met Ser Glu Gly His Arg Gln Lys Ser Glu Phe Tyr Asn 
945                 950                 955                 960 


Arg Thr Ala Ser Glu Ser Asn Val Tyr Leu Asn Ser Phe His Tyr Pro 
                965                 970                 975     


Asp His Ser Tyr Lys Asp Gln Ala Phe Asp Thr Leu Ser Leu Asp Ser 
            980                 985                 990         


Ser Asp Ser Met Glu Thr Ser Ile  Ser Ala Cys Ser Pro  Asp Asn Ile 
        995                 1000                 1005             


Ser Ser  Ala Ser Thr Ser Asn  Ile Ala Arg Ile Glu  Glu Met Glu 
    1010                 1015                 1020             


Arg Leu  Leu Lys Gln Ala His  Ala Glu Lys Thr Arg  Leu Leu Glu 
    1025                 1030                 1035             


Ser Arg  Glu Arg Glu Met Glu  Ala Lys Lys Arg Ala  Leu Glu Glu 
    1040                 1045                 1050             


Glu Lys  Arg Arg Arg Glu Ile  Leu Glu Lys Arg Leu  Gln Glu Glu 
    1055                 1060                 1065             


Thr Ser  Gln Arg Gln Lys Leu  Ile Glu Lys Glu Val  Lys Ile Arg 
    1070                 1075                 1080             


Glu Arg  Gln Arg Ala Gln Ala  Arg Pro Leu Thr Arg  Tyr Leu Pro 
    1085                 1090                 1095             


Val Arg  Lys Glu Asp Phe Asp  Leu Arg Ser His Val  Glu Thr Ala 
    1100                 1105                 1110             


Gly His  Asn Ile Asp Thr Cys  Tyr His Val Ser Ile  Thr Glu Lys 
    1115                 1120                 1125             


Thr Cys  Arg Gly Phe Leu Ile  Lys Met Gly Gly Lys  Ile Lys Thr 
    1130                 1135                 1140             


Trp Lys  Lys Arg Trp Phe Val  Phe Asp Arg Asn Lys  Arg Thr Phe 
    1145                 1150                 1155             


Ser Tyr  Tyr Ala Asp Lys His  Glu Thr Lys Leu Lys  Gly Val Ile 
    1160                 1165                 1170             


Tyr Phe  Gln Ala Ile Glu Glu  Val Tyr Tyr Asp His  Leu Lys Asn 
    1175                 1180                 1185             


Ala Asn  Lys Ser Pro Asn Pro  Leu Leu Thr Phe Ser  Val Lys Thr 
    1190                 1195                 1200             


His Asp  Arg Ile Tyr Tyr Met  Val Ala Pro Ser Pro  Glu Ala Met 
    1205                 1210                 1215             


Arg Ile  Trp Met Asp Val Ile  Val Thr Gly Ala Glu  Gly Tyr Thr 
    1220                 1225                 1230             


His Phe  Leu Leu 
    1235         


<210>  1499
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  1499

Met Phe Thr Leu Ala Glu Val Ala Ser Leu Asn Asp Ile Gln Pro Thr 
1               5                   10                  15      


Tyr Arg Ile Leu Lys Pro Trp Trp Asp Val Phe Met Asp Tyr Leu Ala 
            20                  25                  30          


Val Val Met Leu Met Val Ala Ile Phe Ala Gly Thr Met Gln Leu Thr 
        35                  40                  45              


Lys Asp Gln Val Val Cys Leu Pro Val Leu Pro Ser Pro Val Asn Ser 
    50                  55                  60                  


Lys Ala His Thr Pro Pro Gly Asn Ala Glu Val Thr Thr Asn Ile Pro 
65                  70                  75                  80  


Lys Met Glu Ala Ala Thr Asn Gln Asp Gln Asp Gly Arg Thr Thr Asn 
                85                  90                  95      


Asp Ile Ser Phe Gly Thr Ser Ala Val Thr Pro Asp Ile Pro Leu Arg 
            100                 105                 110         


Ala Thr Tyr Pro Arg Thr Asp Phe Ala Leu Pro Asn Gln Glu Ala Lys 
        115                 120                 125             


Lys Glu Lys Lys Asp Pro Thr Gly Arg Lys Thr Asn Leu Asp Phe Gln 
    130                 135                 140                 


Gln Tyr Val Phe Ile Asn Gln Met Cys Tyr His Leu Ala Leu Pro Trp 
145                 150                 155                 160 


Tyr Ser Lys Tyr Phe Pro Tyr Leu Ala Leu Ile His Thr Ile Ile Leu 
                165                 170                 175     


Met Val Ser Ser Asn Phe Trp Phe Lys Tyr Pro Lys Thr Cys Ser Lys 
            180                 185                 190         


Val Glu His Phe Val Ser Ile Leu Gly Lys Cys Phe Glu Ser Pro Trp 
        195                 200                 205             


Thr Thr Lys Ala Leu Ser Glu Thr Ala Cys Glu Asp Ser Glu Glu Asn 
    210                 215                 220                 


Lys Gln Arg Ile Thr Gly Ala Gln Thr Leu Pro Lys His Val Ser Thr 
225                 230                 235                 240 


Ser Ser Asp Glu Gly Ser Pro Ser Ala Ser Thr Pro Met Ile Asn Lys 
                245                 250                 255     


Thr Gly Phe Lys Phe Ser Ala Glu Lys Pro Val Ile Glu Val Pro Ser 
            260                 265                 270         


Met Thr Ile Leu Asp Lys Lys Asp Gly Glu Gln Ala Lys Ala Leu Phe 
        275                 280                 285             


Glu Lys Val Arg Lys Phe Arg Ala His Val Glu Asp Ser Asp Leu Ile 
    290                 295                 300                 


Tyr Lys Leu Tyr Val Val Gln Thr Val Ile Lys Thr Ala Lys Phe Ile 
305                 310                 315                 320 


Phe Ile Leu Cys Tyr Thr Ala Asn Phe Val Asn Ala Ile Ser Phe Glu 
                325                 330                 335     


His Val Cys Lys Pro Lys Val Glu His Leu Ile Gly Tyr Glu Val Phe 
            340                 345                 350         


Glu Cys Thr His Asn Met Ala Tyr Met Leu Lys Lys Leu Leu Ile Ser 
        355                 360                 365             


Tyr Ile Ser Ile Ile Cys Val Tyr Gly Phe Ile Cys Leu Tyr Thr Leu 
    370                 375                 380                 


Phe Trp Leu Phe Arg Ile Pro Leu Lys Glu Tyr Ser Phe Glu Lys Val 
385                 390                 395                 400 


Arg Glu Glu Ser Ser Phe Ser Asp Ile Pro Asp Val Lys Asn Asp Phe 
                405                 410                 415     


Ala Phe Leu Leu His Met Val Asp Gln Tyr Asp Gln Leu Tyr Ser Lys 
            420                 425                 430         


Arg Phe Gly Val Phe Leu Ser Glu Val Ser Glu Asn Lys Leu Arg Glu 
        435                 440                 445             


Ile Ser Leu Asn His Glu Trp Thr Phe Glu Lys Leu Arg Gln His Ile 
    450                 455                 460                 


Ser Arg Asn Ala Gln Asp Lys Gln Glu Leu His Leu Phe Met Leu Ser 
465                 470                 475                 480 


Gly Val Pro Asp Ala Val Phe Asp Leu Thr Asp Leu Asp Val Leu Lys 
                485                 490                 495     


Leu Glu Leu Ile Pro Glu Ala Lys Ile Pro Ala Lys Ile Ser Gln Met 
            500                 505                 510         


Thr Asn Leu Gln Glu Leu His Leu Cys His Cys Pro Ala Lys Val Glu 
        515                 520                 525             


Gln Thr Ala Phe Ser Phe Leu Arg Asp His Leu Arg Cys Leu His Val 
    530                 535                 540                 


Lys Phe Thr Asp Val Ala Glu Ile Pro Ala Trp Val Tyr Leu Leu Lys 
545                 550                 555                 560 


Asn Leu Arg Glu Leu Tyr Leu Ile Gly Asn Leu Asn Ser Glu Asn Asn 
                565                 570                 575     


Lys Met Ile Gly Leu Glu Ser Leu Arg Glu Leu Arg His Leu Lys Ile 
            580                 585                 590         


Leu His Val Lys Ser Asn Leu Thr Lys Val Pro Ser Asn Ile Thr Asp 
        595                 600                 605             


Val Ala Pro His Leu Thr Lys Leu Val Ile His Asn Asp Gly Thr Lys 
    610                 615                 620                 


Leu Leu Val Leu Asn Ser Leu Lys Lys Met Met Asn Val Ala Glu Leu 
625                 630                 635                 640 


Glu Leu Gln Asn Cys Glu Leu Glu Arg Ile Pro His Ala Ile Phe Ser 
                645                 650                 655     


Leu Ser Asn Leu Gln Glu Leu Asp Leu Lys Ser Asn Asn Ile Arg Thr 
            660                 665                 670         


Ile Glu Glu Ile Ile Ser Phe Gln His Leu Lys Arg Leu Thr Cys Leu 
        675                 680                 685             


Lys Leu Trp His Asn Lys Ile Val Thr Ile Pro Pro Ser Ile Thr His 
    690                 695                 700                 


Val Lys Asn Leu Glu Ser Leu Tyr Phe Ser Asn Asn Lys Leu Glu Ser 
705                 710                 715                 720 


Leu Pro Val Ala Val Phe Ser Leu Gln Lys Leu Arg Cys Leu Asp Val 
                725                 730                 735     


Ser Tyr Asn Asn Ile Ser Met Ile Pro Ile Glu Ile Gly Leu Leu Gln 
            740                 745                 750         


Asn Leu Gln His Leu His Ile Thr Gly Asn Lys Val Asp Ile Leu Pro 
        755                 760                 765             


Lys Gln Leu Phe Lys Cys Ile Lys Leu Arg Thr Leu Asn Leu Gly Gln 
    770                 775                 780                 


Asn Cys Ile Thr Ser Leu Pro Glu Lys Val Gly Gln Leu Ser Gln Leu 
785                 790                 795                 800 


Thr Gln Leu Glu Leu Lys Gly Asn Cys Leu Asp Arg Leu Pro Ala Gln 
                805                 810                 815     


Leu Gly Gln Cys Arg Met Leu Lys Lys Ser Gly Leu Val Val Glu Asp 
            820                 825                 830         


His Leu Phe Asp Thr Leu Pro Leu Glu Val Lys Glu Ala Leu Asn Gln 
        835                 840                 845             


Asp Ile Asn Ile Pro Phe Ala Asn Gly Ile 
    850                 855             


<210>  1500
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  1500

Met Arg Pro Gln Asp Ser Thr Gly Val Ala Glu Leu Gln Glu Pro Gly 
1               5                   10                  15      


Leu Pro Leu Thr Asp Asp Ala Pro Pro Gly Ala Thr Glu Glu Pro Ala 
            20                  25                  30          


Ala Ala Glu Ala Ala Gly Ala Pro Asp Arg Gly Arg Cys Trp Leu Cys 
        35                  40                  45              


Leu Ser Ser Pro Cys Cys Ser Arg Thr Glu Pro Glu Ala Lys Lys Lys 
    50                  55                  60                  


Ala Pro Cys Pro Gly Leu Gly Leu Phe Tyr Thr Leu Leu Ser Ala Phe 
65                  70                  75                  80  


Leu Phe Ser Val Gly Ser Leu Phe Val Lys Lys Val Gln Asp Val His 
                85                  90                  95      


Ala Val Glu Ile Ser Ala Phe Arg Cys Val Phe Gln Met Leu Val Val 
            100                 105                 110         


Ile Pro Cys Leu Ile Tyr Arg Lys Thr Gly Phe Ile Gly Pro Lys Gly 
        115                 120                 125             


Gln Arg Ile Phe Leu Ile Leu Arg Gly Val Leu Gly Ser Thr Ala Met 
    130                 135                 140                 


Met Leu Ile Tyr Tyr Ala Tyr Gln Thr Met Ser Leu Ala Asp Ala Thr 
145                 150                 155                 160 


Val Ile Thr Phe Ser Ser Pro Val Phe Thr Ser Ile Phe Ala Trp Ile 
                165                 170                 175     


Cys Leu Lys Glu Lys Tyr Ser Pro Trp Asp Ala Leu Phe Thr Val Phe 
            180                 185                 190         


Thr Ile Thr Gly Val Ile Leu Ile Val Arg Pro Pro Phe Leu Phe Gly 
        195                 200                 205             


Ser Asp Thr Ser Gly Met Glu Glu Ser Tyr Ser Gly His Leu Lys Gly 
    210                 215                 220                 


Thr Phe Ala Ala Ile Gly Ser Ala Val Phe Ala Ala Ser Thr Leu Val 
225                 230                 235                 240 


Ile Leu Arg Lys Met Gly Lys Ser Val Asp Tyr Phe Leu Ser Ile Trp 
                245                 250                 255     


Tyr Tyr Val Val Leu Gly Leu Val Glu Ser Val Ile Ile Leu Ser Val 
            260                 265                 270         


Leu Gly Glu Trp Ser Leu Pro Tyr Cys Gly Leu Asp Arg Leu Phe Leu 
        275                 280                 285             


Ile Phe Ile Gly Leu Phe Gly Leu Gly Gly Gln Ile Phe Ile Thr Lys 
    290                 295                 300                 


Ala Leu Gln Ile Glu Lys Ala Gly Pro Val Ala Ile Met Lys Thr Met 
305                 310                 315                 320 


Asp Val Val Phe Ala Phe Ile Phe Gln Ile Ile Phe Phe Asn Asn Val 
                325                 330                 335     


Pro Thr Trp Trp Thr Val Gly Gly Ala Leu Cys Val Val Ala Ser Asn 
            340                 345                 350         


Val Gly Ala Ala Ile Arg Lys Trp Tyr Gln Ser Ser Lys 
        355                 360                 365 


<210>  1501
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  1501

Met Leu Gly Pro Gln Val Trp Ser Ser Val Arg Gln Gly Leu Ser Arg 
1               5                   10                  15      


Ser Leu Ser Arg Asn Val Gly Val Trp Ala Ser Gly Glu Gly Lys Lys 
            20                  25                  30          


Val Asp Ile Ala Gly Ile Tyr Pro Pro Val Thr Thr Pro Phe Thr Ala 
        35                  40                  45              


Thr Ala Glu Val Asp Tyr Gly Lys Leu Glu Glu Asn Leu His Lys Leu 
    50                  55                  60                  


Gly Thr Phe Pro Phe Arg Gly Ala Val Gly Gly Val Cys Ala Leu Ala 
65                  70                  75                  80  


Asn Val Leu Gly Ala Gln Val Cys Gln Leu Glu Arg Leu Cys Cys Thr 
                85                  90                  95      


Gly Gln Trp Glu Asp Ala Gln Lys Leu Gln His Arg Leu Ile Glu Pro 
            100                 105                 110         


Asn Ala Ala Val Thr Arg Arg Phe Gly Ile Pro Gly Leu Lys Lys Ile 
        115                 120                 125             


Met Asp Trp Phe Gly Tyr Tyr Gly Gly Pro Cys Arg Ala Pro Leu Gln 
    130                 135                 140                 


Glu Leu Ser Pro Ala Glu Glu Glu Ala Leu Arg Met Asp Phe Thr Ser 
145                 150                 155                 160 


Asn Gly Trp Leu 
                


<210>  1502
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  1502

Met Ser Asp Ile Gly Asp Trp Phe Arg Ser Ile Pro Ala Ile Thr Arg 
1               5                   10                  15      


Tyr Trp Phe Ala Ala Thr Val Ala Val Pro Leu Val Gly Lys Leu Gly 
            20                  25                  30          


Leu Ile Ser Pro Ala Tyr Leu Phe Leu Trp Pro Glu Ala Phe Leu Tyr 
        35                  40                  45              


Arg Phe Gln Ile Trp Arg Pro Ile Thr Ala Thr Phe Tyr Phe Pro Val 
    50                  55                  60                  


Gly Pro Gly Thr Gly Phe Leu Tyr Leu Val Asn Leu Tyr Phe Leu Tyr 
65                  70                  75                  80  


Gln Tyr Ser Thr Arg Leu Glu Thr Gly Ala Phe Asp Gly Arg Pro Ala 
                85                  90                  95      


Asp Tyr Leu Phe Met Leu Leu Phe Asn Trp Ile Cys Ile Val Ile Thr 
            100                 105                 110         


Gly Leu Ala Met Asp Met Gln Leu Leu Met Ile Pro Leu Ile Met Ser 
        115                 120                 125             


Val Leu Tyr Val Trp Ala Gln Leu Asn Arg Asp Met Ile Val Ser Phe 
    130                 135                 140                 


Trp Phe Gly Thr Arg Phe Lys Ala Cys Tyr Leu Pro Trp Val Ile Leu 
145                 150                 155                 160 


Gly Phe Asn Tyr Ile Ile Gly Gly Ser Tyr Pro Met Asp Leu Gly Gly 
                165                 170                 175     


Arg Asn Phe Leu Ser Thr Pro Gln Phe Leu Tyr Arg Trp Leu Pro Ser 
            180                 185                 190         


Arg Arg Gly Gly Val Ser Gly Phe Gly Val Pro Pro Ala Ser Met Arg 
        195                 200                 205             


Arg Ala Ala Asp Gln Asn Gly Gly Gly Gly Arg His Asn Trp Gly Gln 
    210                 215                 220                 


Gly Phe Arg Leu Gly Asp Gln 
225                 230     


<210>  1503
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  1503

Met Ile Thr Asp Val Gln Leu Ala Ile Phe Ala Asn Met Leu Gly Val 
1               5                   10                  15      


Ser Leu Phe Leu Leu Val Val Leu Tyr His Tyr Val Ala Val Asn Asn 
            20                  25                  30          


Pro Lys Lys Gln Glu 
        35          


<210>  1504
<211>  1094
<212>  PRT
<213>  Homo sapiens

<400>  1504

Met Glu Asp Glu Ala Val Leu Asp Arg Gly Ala Ser Phe Leu Lys His 
1               5                   10                  15      


Val Cys Asp Glu Glu Glu Val Glu Gly His His Thr Ile Tyr Ile Gly 
            20                  25                  30          


Val His Val Pro Lys Ser Tyr Arg Arg Arg Arg Arg His Lys Arg Lys 
        35                  40                  45              


Thr Gly His Lys Glu Lys Lys Glu Lys Glu Arg Ile Ser Glu Asn Tyr 
    50                  55                  60                  


Ser Asp Lys Ser Asp Ile Glu Asn Ala Asp Glu Ser Ser Ser Ser Ile 
65                  70                  75                  80  


Leu Lys Pro Leu Ile Ser Pro Ala Ala Glu Arg Ile Arg Phe Ile Leu 
                85                  90                  95      


Gly Glu Glu Asp Asp Ser Pro Ala Pro Pro Gln Leu Phe Thr Glu Leu 
            100                 105                 110         


Asp Glu Leu Leu Ala Val Asp Gly Gln Glu Met Glu Trp Lys Glu Thr 
        115                 120                 125             


Ala Arg Trp Ile Lys Phe Glu Glu Lys Val Glu Gln Gly Gly Glu Arg 
    130                 135                 140                 


Trp Ser Lys Pro His Val Ala Thr Leu Ser Leu His Ser Leu Phe Glu 
145                 150                 155                 160 


Leu Arg Thr Cys Met Glu Lys Gly Ser Ile Met Leu Asp Arg Glu Ala 
                165                 170                 175     


Ser Ser Leu Pro Gln Leu Val Glu Met Ile Val Asp His Gln Ile Glu 
            180                 185                 190         


Thr Gly Leu Leu Lys Pro Glu Leu Lys Asp Lys Val Thr Tyr Thr Leu 
        195                 200                 205             


Leu Arg Lys His Arg His Gln Thr Lys Lys Ser Asn Leu Arg Ser Leu 
    210                 215                 220                 


Ala Asp Ile Gly Lys Thr Val Ser Ser Ala Ser Arg Met Phe Thr Asn 
225                 230                 235                 240 


Pro Asp Asn Gly Ser Pro Ala Met Thr His Arg Asn Leu Thr Ser Ser 
                245                 250                 255     


Ser Leu Asn Asp Ile Ser Asp Lys Pro Glu Lys Asp Gln Leu Lys Asn 
            260                 265                 270         


Lys Phe Met Lys Lys Leu Pro Arg Asp Ala Glu Ala Ser Asn Val Leu 
        275                 280                 285             


Val Gly Glu Val Asp Phe Leu Asp Thr Pro Phe Ile Ala Phe Val Arg 
    290                 295                 300                 


Leu Gln Gln Ala Val Met Leu Gly Ala Leu Thr Glu Val Pro Val Pro 
305                 310                 315                 320 


Thr Arg Phe Leu Phe Ile Leu Leu Gly Pro Lys Gly Lys Ala Lys Ser 
                325                 330                 335     


Tyr His Glu Ile Gly Arg Ala Ile Ala Thr Leu Met Ser Asp Glu Val 
            340                 345                 350         


Phe His Asp Ile Ala Tyr Lys Ala Lys Asp Arg His Asp Leu Ile Ala 
        355                 360                 365             


Gly Ile Asp Glu Phe Leu Asp Glu Val Ile Val Leu Pro Pro Gly Glu 
    370                 375                 380                 


Trp Asp Pro Ala Ile Arg Ile Glu Pro Pro Lys Ser Leu Pro Ser Ser 
385                 390                 395                 400 


Asp Lys Arg Lys Asn Met Tyr Ser Gly Gly Glu Asn Val Gln Met Asn 
                405                 410                 415     


Gly Asp Thr Pro His Asp Gly Gly His Gly Gly Gly Gly His Gly Asp 
            420                 425                 430         


Cys Glu Glu Leu Gln Arg Thr Gly Arg Phe Cys Gly Gly Leu Ile Lys 
        435                 440                 445             


Asp Ile Lys Arg Lys Ala Pro Phe Phe Ala Ser Asp Phe Tyr Asp Ala 
    450                 455                 460                 


Leu Asn Ile Gln Ala Leu Ser Ala Ile Leu Phe Ile Tyr Leu Ala Thr 
465                 470                 475                 480 


Val Thr Asn Ala Ile Thr Phe Gly Gly Leu Leu Gly Asp Ala Thr Asp 
                485                 490                 495     


Asn Met Gln Gly Val Leu Glu Ser Phe Leu Gly Thr Ala Val Ser Gly 
            500                 505                 510         


Ala Ile Phe Cys Leu Phe Ala Gly Gln Pro Leu Thr Ile Leu Ser Ser 
        515                 520                 525             


Thr Gly Pro Val Leu Val Phe Glu Arg Leu Leu Phe Asn Phe Ser Lys 
    530                 535                 540                 


Asp Asn Asn Phe Asp Tyr Leu Glu Phe Arg Leu Trp Ile Gly Leu Trp 
545                 550                 555                 560 


Ser Ala Phe Leu Cys Leu Ile Leu Val Ala Thr Asp Ala Ser Phe Leu 
                565                 570                 575     


Val Gln Tyr Phe Thr Arg Phe Thr Glu Glu Gly Phe Ser Ser Leu Ile 
            580                 585                 590         


Ser Phe Ile Phe Ile Tyr Asp Ala Phe Lys Lys Met Ile Lys Leu Ala 
        595                 600                 605             


Asp Tyr Tyr Pro Ile Asn Ser Asn Phe Lys Val Gly Tyr Asn Thr Leu 
    610                 615                 620                 


Phe Ser Cys Thr Cys Val Pro Pro Asp Pro Ala Asn Ile Ser Ile Ser 
625                 630                 635                 640 


Asn Asp Thr Thr Leu Ala Pro Glu Tyr Leu Pro Thr Met Ser Ser Thr 
                645                 650                 655     


Asp Met Tyr His Asn Thr Thr Phe Asp Trp Ala Phe Leu Ser Lys Lys 
            660                 665                 670         


Glu Cys Ser Lys Tyr Gly Gly Asn Leu Val Gly Asn Asn Cys Asn Phe 
        675                 680                 685             


Val Pro Asp Ile Thr Leu Met Ser Phe Ile Leu Phe Leu Gly Thr Tyr 
    690                 695                 700                 


Thr Ser Ser Met Ala Leu Lys Lys Phe Lys Thr Ser Pro Tyr Phe Pro 
705                 710                 715                 720 


Thr Thr Ala Arg Lys Leu Ile Ser Asp Phe Ala Ile Ile Leu Ser Ile 
                725                 730                 735     


Leu Ile Phe Cys Val Ile Asp Ala Leu Val Gly Val Asp Thr Pro Lys 
            740                 745                 750         


Leu Ile Val Pro Ser Glu Phe Lys Pro Thr Ser Pro Asn Arg Gly Trp 
        755                 760                 765             


Phe Val Pro Pro Phe Gly Glu Asn Pro Trp Trp Val Cys Leu Ala Ala 
    770                 775                 780                 


Ala Ile Pro Ala Leu Leu Val Thr Ile Leu Ile Phe Met Asp Gln Gln 
785                 790                 795                 800 


Ile Thr Ala Val Ile Val Asn Arg Lys Glu His Lys Leu Lys Lys Gly 
                805                 810                 815     


Ala Gly Tyr His Leu Asp Leu Phe Trp Val Ala Ile Leu Met Val Ile 
            820                 825                 830         


Cys Ser Leu Met Ala Leu Pro Trp Tyr Val Ala Ala Thr Val Ile Ser 
        835                 840                 845             


Ile Ala His Ile Asp Ser Leu Lys Met Glu Thr Glu Thr Ser Ala Pro 
    850                 855                 860                 


Gly Glu Gln Pro Lys Phe Leu Gly Val Arg Glu Gln Arg Val Thr Gly 
865                 870                 875                 880 


Thr Leu Val Phe Ile Leu Thr Gly Leu Ser Val Phe Met Ala Pro Ile 
                885                 890                 895     


Leu Lys Phe Ile Pro Met Pro Val Leu Tyr Gly Val Phe Leu Tyr Met 
            900                 905                 910         


Gly Val Ala Ser Leu Asn Gly Val Gln Phe Met Asp Arg Leu Lys Leu 
        915                 920                 925             


Leu Leu Met Pro Leu Lys His Gln Pro Asp Phe Ile Tyr Leu Arg His 
    930                 935                 940                 


Val Pro Leu Arg Arg Val His Leu Phe Thr Phe Leu Gln Val Leu Cys 
945                 950                 955                 960 


Leu Ala Leu Leu Trp Ile Leu Lys Ser Thr Val Ala Ala Ile Ile Phe 
                965                 970                 975     


Pro Val Met Ile Leu Ala Leu Val Ala Val Arg Lys Gly Met Asp Tyr 
            980                 985                 990         


Leu Phe Ser Gln His Asp Leu Ser  Phe Leu Asp Asp Val  Ile Pro Glu 
        995                 1000                 1005             


Lys Asp  Lys Lys Lys Lys Glu  Asp Glu Lys Lys Lys  Lys Lys Lys 
    1010                 1015                 1020             


Lys Gly  Ser Leu Asp Ser Asp  Asn Asp Asp Glu Lys  Asp His Gln 
    1025                 1030                 1035             


His Ser  Leu Asn Ala Thr His  His Ala Asp Lys Ile  Pro Phe Leu 
    1040                 1045                 1050             


Gln Ser  Leu Gly Met Pro Ser  Pro Pro Arg Thr Pro  Val Lys Val 
    1055                 1060                 1065             


Val Pro  Gln Ile Arg Ile Glu  Leu Glu Pro Glu Asp  Asn Asp Tyr 
    1070                 1075                 1080             


Phe Trp  Arg Ser Lys Gly Thr  Glu Thr Thr Leu 
    1085                 1090                 


<210>  1505
<211>  590
<212>  PRT
<213>  Homo sapiens

<400>  1505

Met Gly Phe His Leu Ile Thr Gln Leu Lys Gly Met Ser Val Val Leu 
1               5                   10                  15      


Val Leu Leu Pro Thr Leu Leu Leu Val Met Leu Thr Gly Ala Gln Arg 
            20                  25                  30          


Ala Cys Pro Lys Asn Cys Arg Cys Asp Gly Lys Ile Val Tyr Cys Glu 
        35                  40                  45              


Ser His Ala Phe Ala Asp Ile Pro Glu Asn Ile Ser Gly Gly Ser Gln 
    50                  55                  60                  


Gly Leu Ser Leu Arg Phe Asn Ser Ile Gln Lys Leu Lys Ser Asn Gln 
65                  70                  75                  80  


Phe Ala Gly Leu Asn Gln Leu Ile Trp Leu Tyr Leu Asp His Asn Tyr 
                85                  90                  95      


Ile Ser Ser Val Asp Glu Asp Ala Phe Gln Gly Ile Arg Arg Leu Lys 
            100                 105                 110         


Glu Leu Ile Leu Ser Ser Asn Lys Ile Thr Tyr Leu His Asn Lys Thr 
        115                 120                 125             


Phe His Pro Val Pro Asn Leu Arg Asn Leu Asp Leu Ser Tyr Asn Lys 
    130                 135                 140                 


Leu Gln Thr Leu Gln Ser Glu Gln Phe Lys Gly Leu Arg Lys Leu Ile 
145                 150                 155                 160 


Ile Leu His Leu Arg Ser Asn Ser Leu Lys Thr Val Pro Ile Arg Val 
                165                 170                 175     


Phe Gln Asp Cys Arg Asn Leu Asp Phe Leu Asp Leu Gly Tyr Asn Arg 
            180                 185                 190         


Leu Arg Ser Leu Ser Arg Asn Ala Phe Ala Gly Leu Leu Lys Leu Lys 
        195                 200                 205             


Glu Leu His Leu Glu His Asn Gln Phe Ser Lys Ile Asn Phe Ala His 
    210                 215                 220                 


Phe Pro Arg Leu Phe Asn Leu Arg Ser Ile Tyr Leu Gln Trp Asn Arg 
225                 230                 235                 240 


Ile Arg Ser Ile Ser Gln Gly Leu Thr Trp Thr Trp Ser Ser Leu His 
                245                 250                 255     


Asn Leu Asp Leu Ser Gly Asn Asp Ile Gln Gly Ile Glu Pro Gly Thr 
            260                 265                 270         


Phe Lys Cys Leu Pro Asn Leu Gln Lys Leu Asn Leu Asp Ser Asn Lys 
        275                 280                 285             


Leu Thr Asn Ile Ser Gln Glu Thr Val Asn Ala Trp Ile Ser Leu Ile 
    290                 295                 300                 


Ser Ile Thr Leu Ser Gly Asn Met Trp Glu Cys Ser Arg Ser Ile Cys 
305                 310                 315                 320 


Pro Leu Phe Tyr Trp Leu Lys Asn Phe Lys Gly Asn Lys Glu Ser Thr 
                325                 330                 335     


Met Ile Cys Ala Gly Pro Lys His Ile Gln Gly Glu Lys Val Ser Asp 
            340                 345                 350         


Ala Val Glu Thr Tyr Asn Ile Cys Ser Glu Val Gln Val Val Asn Thr 
        355                 360                 365             


Glu Arg Ser His Leu Val Pro Gln Thr Pro Gln Lys Pro Leu Ile Ile 
    370                 375                 380                 


Pro Arg Pro Thr Ile Phe Lys Pro Asp Val Thr Gln Ser Thr Phe Glu 
385                 390                 395                 400 


Thr Pro Ser Pro Ser Pro Gly Phe Gln Ile Pro Gly Ala Glu Gln Glu 
                405                 410                 415     


Tyr Glu His Val Ser Phe His Lys Ile Ile Ala Gly Ser Val Ala Leu 
            420                 425                 430         


Phe Leu Ser Val Ala Met Ile Leu Leu Val Ile Tyr Val Ser Trp Lys 
        435                 440                 445             


Arg Tyr Pro Ala Ser Met Lys Gln Leu Gln Gln His Ser Leu Met Lys 
    450                 455                 460                 


Arg Arg Arg Lys Lys Ala Arg Glu Ser Glu Arg Gln Met Asn Ser Pro 
465                 470                 475                 480 


Leu Gln Glu Tyr Tyr Val Asp Tyr Lys Pro Thr Asn Ser Glu Thr Met 
                485                 490                 495     


Asp Ile Ser Val Asn Gly Ser Gly Pro Cys Thr Tyr Thr Ile Ser Gly 
            500                 505                 510         


Ser Arg Glu Cys Glu Met Pro His His Met Lys Pro Leu Pro Tyr Tyr 
        515                 520                 525             


Ser Tyr Asp Gln Pro Val Ile Gly Tyr Cys Gln Ala His Gln Pro Leu 
    530                 535                 540                 


His Val Thr Lys Gly Tyr Glu Thr Val Ser Pro Glu Gln Asp Glu Ser 
545                 550                 555                 560 


Pro Gly Leu Glu Leu Gly Arg Asp His Ser Phe Ile Ala Thr Ile Ala 
                565                 570                 575     


Arg Ser Ala Ala Pro Ala Ile Tyr Leu Glu Arg Ile Ala Asn 
            580                 585                 590 


<210>  1506
<211>  1139
<212>  PRT
<213>  Homo sapiens

<400>  1506

Met Ser Arg Arg Phe Thr Val Thr Ser Leu Pro Pro Ala Gly Pro Ala 
1               5                   10                  15      


Arg Ser Pro Asp Pro Glu Ser Arg Arg His Ser Val Ala Asp Pro Arg 
            20                  25                  30          


His Leu Pro Gly Glu Asp Val Lys Gly Asp Gly Asn Pro Lys Glu Ser 
        35                  40                  45              


Ser Pro Phe Ile Asn Ser Thr Asp Thr Glu Lys Gly Lys Glu Tyr Asp 
    50                  55                  60                  


Gly Lys Asn Met Ala Leu Phe Glu Glu Glu Met Asp Thr Ser Pro Met 
65                  70                  75                  80  


Val Ser Ser Leu Leu Ser Gly Leu Ala Asn Tyr Thr Asn Leu Pro Gln 
                85                  90                  95      


Gly Ser Arg Glu His Glu Glu Ala Glu Asn Asn Glu Gly Gly Lys Lys 
            100                 105                 110         


Lys Pro Val Gln Ala Pro Arg Met Gly Thr Phe Met Gly Val Tyr Leu 
        115                 120                 125             


Pro Cys Leu Gln Asn Ile Phe Gly Val Ile Leu Phe Leu Arg Leu Thr 
    130                 135                 140                 


Trp Val Val Gly Ile Ala Gly Ile Met Glu Ser Phe Cys Met Val Phe 
145                 150                 155                 160 


Ile Cys Cys Ser Cys Thr Met Leu Thr Ala Ile Ser Met Ser Ala Ile 
                165                 170                 175     


Ala Thr Asn Gly Val Val Pro Ala Gly Gly Ser Tyr Tyr Met Ile Ser 
            180                 185                 190         


Arg Ser Leu Gly Pro Glu Phe Gly Gly Ala Val Gly Leu Cys Phe Tyr 
        195                 200                 205             


Leu Gly Thr Thr Phe Ala Gly Ala Met Tyr Ile Leu Gly Thr Ile Glu 
    210                 215                 220                 


Ile Leu Leu Ala Tyr Leu Phe Pro Ala Met Ala Ile Phe Lys Ala Glu 
225                 230                 235                 240 


Asp Ala Ser Gly Glu Ala Ala Ala Met Leu Asn Asn Met Arg Val Tyr 
                245                 250                 255     


Gly Thr Cys Val Leu Thr Cys Met Ala Thr Val Val Phe Val Gly Val 
            260                 265                 270         


Lys Tyr Val Asn Lys Phe Ala Leu Val Phe Leu Gly Cys Val Ile Leu 
        275                 280                 285             


Ser Ile Leu Ala Ile Tyr Ala Gly Val Ile Lys Ser Ala Phe Asp Pro 
    290                 295                 300                 


Pro Asn Phe Pro Ile Cys Leu Leu Gly Asn Arg Thr Leu Ser Arg His 
305                 310                 315                 320 


Gly Phe Asp Val Cys Ala Lys Leu Ala Trp Glu Gly Asn Glu Thr Val 
                325                 330                 335     


Thr Thr Arg Leu Trp Gly Leu Phe Cys Ser Ser Arg Phe Leu Asn Ala 
            340                 345                 350         


Thr Cys Asp Glu Tyr Phe Thr Arg Asn Asn Val Thr Glu Ile Gln Gly 
        355                 360                 365             


Ile Pro Gly Ala Ala Ser Gly Leu Ile Lys Glu Asn Leu Trp Ser Ser 
    370                 375                 380                 


Tyr Leu Thr Lys Gly Val Ile Val Glu Arg Ser Gly Met Thr Ser Val 
385                 390                 395                 400 


Gly Leu Ala Asp Gly Thr Pro Ile Asp Met Asp His Pro Tyr Val Phe 
                405                 410                 415     


Ser Asp Met Thr Ser Tyr Phe Thr Leu Leu Val Gly Ile Tyr Phe Pro 
            420                 425                 430         


Ser Val Thr Gly Ile Met Ala Gly Ser Asn Arg Ser Gly Asp Leu Arg 
        435                 440                 445             


Asp Ala Gln Lys Ser Ile Pro Thr Gly Thr Ile Leu Ala Ile Ala Thr 
    450                 455                 460                 


Thr Ser Ala Val Tyr Ile Ser Ser Val Val Leu Phe Gly Ala Cys Ile 
465                 470                 475                 480 


Glu Gly Val Val Leu Arg Asp Lys Phe Gly Glu Ala Val Asn Gly Asn 
                485                 490                 495     


Leu Val Val Gly Thr Leu Ala Trp Pro Ser Pro Trp Val Ile Val Ile 
            500                 505                 510         


Gly Ser Phe Phe Ser Thr Cys Gly Ala Gly Leu Gln Ser Leu Thr Gly 
        515                 520                 525             


Ala Pro Arg Leu Leu Gln Ala Ile Ser Arg Asp Gly Ile Val Pro Phe 
    530                 535                 540                 


Leu Gln Val Phe Gly His Gly Lys Ala Asn Gly Glu Pro Thr Trp Ala 
545                 550                 555                 560 


Leu Leu Leu Thr Ala Cys Ile Cys Glu Ile Gly Ile Leu Ile Ala Ser 
                565                 570                 575     


Leu Asp Glu Val Ala Pro Ile Leu Ser Met Phe Phe Leu Met Cys Tyr 
            580                 585                 590         


Met Phe Val Asn Leu Ala Cys Ala Val Gln Thr Leu Leu Arg Thr Pro 
        595                 600                 605             


Asn Trp Arg Pro Arg Phe Arg Tyr Tyr His Trp Thr Leu Ser Phe Leu 
    610                 615                 620                 


Gly Met Ser Leu Cys Leu Ala Leu Met Phe Ile Cys Ser Trp Tyr Tyr 
625                 630                 635                 640 


Ala Leu Val Ala Met Leu Ile Ala Gly Leu Ile Tyr Lys Tyr Ile Glu 
                645                 650                 655     


Tyr Arg Gly Ala Glu Lys Glu Trp Gly Asp Gly Ile Arg Gly Leu Ser 
            660                 665                 670         


Leu Ser Ala Ala Arg Tyr Ala Leu Leu Arg Leu Glu Glu Gly Pro Pro 
        675                 680                 685             


His Thr Lys Asn Trp Arg Pro Gln Leu Leu Val Leu Val Arg Val Asp 
    690                 695                 700                 


Gln Asp Gln Asn Val Val His Pro Gln Leu Leu Ser Leu Thr Ser Gln 
705                 710                 715                 720 


Leu Lys Ala Gly Lys Gly Leu Thr Ile Val Gly Ser Val Leu Glu Gly 
                725                 730                 735     


Thr Phe Leu Glu Asn His Pro Gln Ala Gln Arg Ala Glu Glu Ser Ile 
            740                 745                 750         


Arg Arg Leu Met Glu Ala Glu Lys Val Lys Gly Phe Cys Gln Val Val 
        755                 760                 765             


Ile Ser Ser Asn Leu Arg Asp Gly Val Ser His Leu Ile Gln Ser Gly 
    770                 775                 780                 


Gly Leu Gly Gly Leu Gln His Asn Thr Val Leu Val Gly Trp Pro Arg 
785                 790                 795                 800 


Asn Trp Arg Gln Lys Glu Asp His Gln Thr Trp Arg Asn Phe Ile Glu 
                805                 810                 815     


Leu Val Arg Glu Thr Thr Ala Gly His Leu Ala Leu Leu Val Thr Lys 
            820                 825                 830         


Asn Val Ser Met Phe Pro Gly Asn Pro Glu Arg Phe Ser Glu Gly Ser 
        835                 840                 845             


Ile Asp Val Trp Trp Ile Val His Asp Gly Gly Met Leu Met Leu Leu 
    850                 855                 860                 


Pro Phe Leu Leu Arg His His Lys Val Trp Arg Lys Cys Lys Met Arg 
865                 870                 875                 880 


Ile Phe Thr Val Ala Gln Met Asp Asp Asn Ser Ile Gln Met Lys Lys 
                885                 890                 895     


Asp Leu Thr Thr Phe Leu Tyr His Leu Arg Ile Thr Ala Glu Val Glu 
            900                 905                 910         


Val Val Glu Met His Glu Ser Asp Ile Ser Ala Tyr Thr Tyr Glu Lys 
        915                 920                 925             


Thr Leu Val Met Glu Gln Arg Ser Gln Ile Leu Lys Gln Met His Leu 
    930                 935                 940                 


Thr Lys Asn Glu Arg Glu Arg Glu Ile Gln Ser Ile Thr Asp Glu Ser 
945                 950                 955                 960 


Arg Gly Ser Ile Arg Arg Lys Asn Pro Ala Asn Thr Arg Leu Arg Leu 
                965                 970                 975     


Asn Val Pro Glu Glu Thr Ala Gly Asp Ser Glu Glu Lys Pro Glu Glu 
            980                 985                 990         


Glu Val Gln Leu Ile His Asp Gln  Ser Ala Pro Ser Cys  Pro Ser Ser 
        995                 1000                 1005             


Ser Pro  Ser Pro Gly Glu Glu  Pro Glu Gly Glu Gly  Glu Thr Asp 
    1010                 1015                 1020             


Pro Glu  Lys Val His Leu Thr  Trp Thr Lys Asp Lys  Ser Val Ala 
    1025                 1030                 1035             


Glu Lys  Asn Lys Gly Pro Ser  Pro Val Ser Ser Glu  Gly Ile Lys 
    1040                 1045                 1050             


Asp Phe  Phe Ser Met Lys Pro  Glu Trp Glu Asn Leu  Asn Gln Ser 
    1055                 1060                 1065             


Asn Val  Arg Arg Met His Thr  Ala Val Arg Leu Asn  Glu Val Ile 
    1070                 1075                 1080             


Val Lys  Lys Ser Arg Asp Ala  Lys Leu Val Leu Leu  Asn Met Pro 
    1085                 1090                 1095             


Gly Pro  Pro Arg Asn Arg Asn  Gly Asp Glu Asn Tyr  Met Glu Phe 
    1100                 1105                 1110             


Leu Glu  Val Leu Thr Glu His  Leu Asp Arg Val Met  Leu Val Arg 
    1115                 1120                 1125             


Gly Gly  Gly Arg Glu Val Ile  Thr Ile Tyr Ser 
    1130                 1135                 


<210>  1507
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  1507

Met Cys Ser Thr Met Ser Ala Pro Thr Cys Leu Ala His Leu Pro Pro 
1               5                   10                  15      


Cys Phe Leu Leu Leu Ala Leu Val Leu Val Pro Ser Asp Ala Ser Gly 
            20                  25                  30          


Gln Ser Ser Arg Asn Asp Trp Gln Val Leu Gln Pro Glu Gly Pro Met 
        35                  40                  45              


Leu Val Ala Glu Gly Ala Gly Asp Pro Glu Pro Asp Leu Trp Ile Ile 
    50                  55                  60                  


Gln Pro Gln Glu Leu Val Leu Gly Thr Thr Gly Asp Thr Val Phe Leu 
65                  70                  75                  80  


Asn Cys Thr Val Leu Gly Asp Gly Pro Pro Gly Pro Ile Arg Trp Phe 
                85                  90                  95      


Gln Gly Ala Gly Leu Ser Arg Glu Ala Ile Tyr Asn Phe Gly Gly Ile 
            100                 105                 110         


Ser His Pro Lys Glu Thr Ala Val Gln Ala Ser Asn Asn Asp Phe Ser 
        115                 120                 125             


Ile Leu Leu Gln Asn Val Ser Ser Glu Asp Ala Gly Thr Tyr Tyr Cys 
    130                 135                 140                 


Val Lys Phe Gln Arg Lys Pro Asn Arg Gln Tyr Leu Ser Gly Gln Gly 
145                 150                 155                 160 


Thr Ser Leu Lys Val Lys Ala Lys Ser Thr Ser Ser Lys Glu Ala Glu 
                165                 170                 175     


Phe Thr Ser Glu Pro Ala Thr Glu Met Ser Pro Thr Gly Leu Leu Val 
            180                 185                 190         


Val Phe Ala Pro Val Val Leu Gly Leu Lys Ala Ile Thr Leu Ala Ala 
        195                 200                 205             


Leu Leu Leu Ala Leu Ala Thr Ser Arg Arg Ser Pro Gly Gln Glu Asp 
    210                 215                 220                 


Val Lys Thr Thr Gly Pro Ala Gly Ala Met Asn Thr Leu Ala Trp Ser 
225                 230                 235                 240 


Lys Gly Gln Glu 
                


<210>  1508
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  1508

Met Pro Ser Pro Gly Thr Val Cys Ser Leu Leu Leu Leu Gly Met Leu 
1               5                   10                  15      


Trp Leu Asp Leu Ala Met Ala Gly Ser Ser Phe Leu Ser Pro Glu His 
            20                  25                  30          


Gln Arg Val Gln Arg Lys Glu Ser Lys Lys Pro Pro Ala Lys Leu Gln 
        35                  40                  45              


Pro Arg Ala Leu Ala Gly Trp Leu Arg Pro Glu Asp Gly Gly Gln Ala 
    50                  55                  60                  


Glu Gly Ala Glu Asp Glu Leu Glu Val Arg Phe Asn Ala Pro Phe Asp 
65                  70                  75                  80  


Val Gly Ile Lys Leu Ser Gly Val Gln Tyr Gln Gln His Ser Gln Ala 
                85                  90                  95      


Leu Gly Lys Phe Leu Gln Asp Ile Leu Trp Glu Glu Ala Lys Glu Ala 
            100                 105                 110         


Pro Ala Asp Lys 
        115     


<210>  1509
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  1509

Met Phe Thr Cys Trp Trp Ser Tyr Leu Arg Ser Thr Leu Ala Ala Val 
1               5                   10                  15      


Pro Gly Glu Ala Ser Arg Val Gln Gln Arg Lys Glu Ser Lys Lys Pro 
            20                  25                  30          


Pro Ala Lys Leu Gln Pro Arg Ala Leu Ala Gly Trp Leu Arg Pro Glu 
        35                  40                  45              


Asp Gly Gly Gln Ala Glu Gly Ala Glu Asp Glu Leu Glu Val Arg Phe 
    50                  55                  60                  


Asn Ala Pro Phe Asp Val Gly Ile Lys Leu Ser Gly Val Gln Tyr Gln 
65                  70                  75                  80  


Gln His Ser Gln Ala Leu Gly Lys Phe Leu Gln Asp Ile Leu Trp Glu 
                85                  90                  95      


Glu Ala Lys Glu Ala Pro Ala Asp Lys 
            100                 105 


<210>  1510
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  1510

Met Phe Thr Cys Trp Trp Ser Tyr Leu Arg Ser Thr Leu Ala Ala Val 
1               5                   10                  15      


Pro Gly Glu Ala Ser Arg Val Gln Arg Lys Glu Ser Lys Lys Pro Pro 
            20                  25                  30          


Ala Lys Leu Gln Pro Arg Ala Leu Ala Gly Trp Leu Arg Pro Glu Asp 
        35                  40                  45              


Gly Gly Gln Ala Glu Gly Ala Glu Asp Glu Leu Glu Val Arg Phe Asn 
    50                  55                  60                  


Ala Pro Phe Asp Val Gly Ile Lys Leu Ser Gly Val Gln Tyr Gln Gln 
65                  70                  75                  80  


His Ser Gln Ala Leu Gly Lys Phe Leu Gln Asp Ile Leu Trp Glu Glu 
                85                  90                  95      


Ala Lys Glu Ala Pro Ala Asp Lys 
            100                 


<210>  1511
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  1511

Met Phe Thr Cys Trp Trp Ser Tyr Leu Arg Ser Thr Leu Ala Ala Val 
1               5                   10                  15      


Pro Gly Glu Ala Ser Arg Val Gln Phe Asn Ala Pro Phe Asp Val Gly 
            20                  25                  30          


Ile Lys Leu Ser Gly Val Gln Tyr Gln Gln His Ser Gln Ala Leu Gly 
        35                  40                  45              


Lys Phe Leu Gln Asp Ile Leu Trp Glu Glu Ala Lys Glu Ala Pro Ala 
    50                  55                  60                  


Asp Lys 
65      


<210>  1512
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  1512

Met Arg Leu Pro Leu Ser His Ser Pro Glu His Val Glu Met Ala Leu 
1               5                   10                  15      


Leu Ser Asn Ile Leu Ala Ala Tyr Ser Phe Val Ser Glu Asn Pro Glu 
            20                  25                  30          


Arg Ala Ala Leu Tyr Phe Val Ser Gly Val Cys Ile Gly Leu Val Leu 
        35                  40                  45              


Thr Leu Ala Ala Leu Val Ile Arg Ile Ser Cys His Thr Asp Cys Arg 
    50                  55                  60                  


Arg Arg Pro Gly Lys Lys Phe Leu Gln Asp Arg Glu Ser Ser Ser Asp 
65                  70                  75                  80  


Ser Ser Asp Ser Glu Asp Gly Ser Glu Asp Thr Val Ser Asp Leu Ser 
                85                  90                  95      


Val Arg Arg His Arg Arg Phe Glu Arg Thr Leu Asn Lys Asn Val Phe 
            100                 105                 110         


Thr Ser Ala Glu Glu Leu Glu Arg Ala Gln Arg Leu Glu Glu Arg Glu 
        115                 120                 125             


Arg Ile Ile Arg Glu Ile Trp Met Asn Gly Gln Pro Glu Val Pro Gly 
    130                 135                 140                 


Thr Arg Ser Leu Asn Arg Tyr Tyr 
145                 150         


<210>  1513
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  1513

Met Leu Gln Gln Asp Ser Asn Asp Asp Thr Glu Asp Val Ser Leu Phe 
1               5                   10                  15      


Asp Ala Glu Glu Glu Thr Thr Asn Arg Pro Arg Lys Ala Lys Ile Arg 
            20                  25                  30          


His Pro Val Ala Ser Phe Phe His Leu Phe Phe Arg Val Ser Ala Ile 
        35                  40                  45              


Ile Val Cys Leu Leu Cys Glu Leu Leu Ser Ser Ser Phe Ile Thr Cys 
    50                  55                  60                  


Met Val Thr Ile Ile Leu Leu Leu Ser Cys Asp Phe Trp Ala Val Lys 
65                  70                  75                  80  


Asn Val Thr Gly Arg Leu Met Val Gly Leu Arg Trp Trp Asn His Ile 
                85                  90                  95      


Asp Glu Asp Gly Lys Ser His Trp Val Phe Glu Ser Arg Lys Glu Ser 
            100                 105                 110         


Ser Gln Glu Asn Lys Thr Val Ser Glu Ala Glu Ser Arg Ile Phe Trp 
        115                 120                 125             


Leu Gly Leu Ile Ala Cys Ser Val Leu Trp Val Ile Phe Ala Phe Ser 
    130                 135                 140                 


Ala Leu Phe Ser Phe Thr Val Lys Trp Leu Ala Val Val Ile Met Gly 
145                 150                 155                 160 


Val Val Leu Gln Gly Ala Asn Leu Tyr Gly Tyr Ile Arg Cys Lys Val 
                165                 170                 175     


Arg Ser Arg Lys His Leu Thr Ser Met Ala Thr Ser Tyr Phe Gly Lys 
            180                 185                 190         


Gln Phe Leu Arg Gln Val Ser Val Phe Trp Met 
        195                 200             


<210>  1514
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  1514

Met Ser Val Tyr Tyr Met Ile Val Cys Leu Ile Ala Phe Thr Ile Thr 
1               5                   10                  15      


Leu Ile Leu Asn Val Thr Arg Leu Cys Met Met Ser Ser His Leu Arg 
            20                  25                  30          


Lys Thr Glu Lys Ala Ile Asn Glu Phe Phe Arg Thr Glu Gly Ala Glu 
        35                  40                  45              


Lys Leu Gln Lys Ala Phe Glu Ile Ala Lys Arg Ile Pro Ile Ile Thr 
    50                  55                  60                  


Ser Ala Lys Thr Leu Glu Leu Ala Lys Val Thr Gln Phe Lys Thr Met 
65                  70                  75                  80  


Glu Phe Ala Arg Tyr Ile Glu Glu Leu Ala Arg Ser Val Pro Leu Pro 
                85                  90                  95      


Pro Leu Ile Leu Asn Cys Arg Ala Phe Val Glu Glu Met Phe Glu Ala 
            100                 105                 110         


Val Arg Val Asp Asp Pro Asp Asp Leu Gly Glu Arg Ile Lys Glu Arg 
        115                 120                 125             


Pro Ala Leu Asn Ala Gln Gly Gly Ile Tyr Val Ile Asn Pro Glu Met 
    130                 135                 140                 


Gly Arg Ser Asn Ser Pro Gly Gly Asp Ser Asp Asp Gly Ser Leu Asn 
145                 150                 155                 160 


Glu Gln Gly Gln Glu Ile Ala Val Gln Val Ser Val His Leu Gln Ser 
                165                 170                 175     


Glu Thr Lys Ser Ile Asp Thr Glu Ser Gln Gly Ser Ser His Phe Ser 
            180                 185                 190         


Pro Pro Asp Asp Ile Gly Ser Ala Glu Ser Asn Cys Asn Tyr Lys Asp 
        195                 200                 205             


Gly Ala Tyr Glu Asn Cys Gln Leu 
    210                 215     


<210>  1515
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  1515

Met Pro Gly Val Cys Asp Arg Ala Pro Asp Phe Leu Ser Pro Ser Glu 
1               5                   10                  15      


Asp Gln Val Leu Arg Pro Ala Leu Gly Ser Ser Val Ala Leu Asn Cys 
            20                  25                  30          


Thr Ala Trp Val Val Ser Gly Pro His Cys Ser Leu Pro Ser Val Gln 
        35                  40                  45              


Trp Leu Lys Asp Gly Leu Pro Leu Gly Ile Gly Gly His Tyr Ser Leu 
    50                  55                  60                  


His Glu Tyr Ser Trp Val Lys Ala Asn Leu Ser Glu Val Leu Val Ser 
65                  70                  75                  80  


Ser Val Leu Gly Val Asn Val Thr Ser Thr Glu Val Tyr Gly Ala Phe 
                85                  90                  95      


Thr Cys Ser Ile Gln Asn Ile Ser Phe Ser Ser Phe Thr Leu Gln Arg 
            100                 105                 110         


Ala Gly Pro Thr Ser His Val Ala Ala Val Leu Ala Ser Leu Leu Val 
        115                 120                 125             


Leu Leu Ala Leu Leu Leu Ala Ala Leu Leu Tyr Val Lys Cys Arg Leu 
    130                 135                 140                 


Asn Val Leu Leu Trp Tyr Gln Asp Ala Tyr Gly Glu Val Glu Ile Asn 
145                 150                 155                 160 


Asp Gly Lys Leu Tyr Asp Ala Tyr Val Ser Tyr Ser Asp Cys Pro Glu 
                165                 170                 175     


Asp Arg Lys Phe Val Asn Phe Ile Leu Lys Pro Gln Leu Glu Arg Arg 
            180                 185                 190         


Arg Gly Tyr Lys Leu Phe Leu Asp Asp Arg Asp Leu Leu Pro Arg Ala 
        195                 200                 205             


Glu Pro Ser Ala Asp Leu Leu Val Asn Leu Ser Arg Cys Arg Arg Leu 
    210                 215                 220                 


Ile Val Val Leu Ser Asp Ala Phe Leu Ser Arg Ala Trp Cys Ser His 
225                 230                 235                 240 


Ser Phe Arg Glu Gly Leu Cys Arg Leu Leu Glu Leu Thr Arg Arg Pro 
                245                 250                 255     


Ile Phe Ile Thr Phe Glu Gly Gln Arg Arg Asp Pro Ala His Pro Ala 
            260                 265                 270         


Leu Arg Leu Leu Arg Gln His Arg His Leu Val Thr Leu Leu Leu Trp 
        275                 280                 285             


Arg Pro Gly Ser Val Thr Pro Ser Ser Asp Phe Trp Lys Glu Val Gln 
    290                 295                 300                 


Leu Ala Leu Pro Arg Lys Val Gln Tyr Arg Pro Val Glu Gly Asp Pro 
305                 310                 315                 320 


Gln Thr Gln Leu Gln Asp Asp Lys Asp Pro Met Leu Ile Leu Arg Gly 
                325                 330                 335     


Arg Val Pro Glu Gly Arg Ala Leu Asp Ser Glu Val Asp Pro Asp Pro 
            340                 345                 350         


Glu Gly Asp Leu Gly Val Arg Gly Pro Val Phe Gly Glu Pro Ser Ala 
        355                 360                 365             


Pro Pro His Thr Ser Gly Val Ser Leu Gly Glu Ser Arg Ser Ser Glu 
    370                 375                 380                 


Val Asp Val Ser Asp Leu Gly Ser Arg Asn Tyr Ser Ala Arg Thr Asp 
385                 390                 395                 400 


Phe Tyr Cys Leu Val Ser Lys Asp Asp Met 
                405                 410 


<210>  1516
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  1516

Met Pro Gly Val Cys Asp Arg Ala Pro Asp Phe Leu Ser Pro Ser Glu 
1               5                   10                  15      


Asp Gln Val Leu Arg Pro Ala Leu Gly Ser Ser Val Ala Leu Asn Cys 
            20                  25                  30          


Thr Ala Trp Val Val Ser Gly Pro His Cys Ser Leu Pro Ser Val Gln 
        35                  40                  45              


Trp Leu Lys Asp Gly Leu Pro Leu Gly Ile Gly Gly His Tyr Ser Leu 
    50                  55                  60                  


His Glu Tyr Ser Trp Val Lys Ala Asn Leu Ser Glu Val Leu Val Ser 
65                  70                  75                  80  


Ser Val Leu Gly Val Asn Val Thr Ser Thr Glu Val Tyr Gly Ala Phe 
                85                  90                  95      


Thr Cys Ser Ile Gln Asn Ile Ser Phe Ser Ser Phe Thr Leu Gln Arg 
            100                 105                 110         


Ala Gly Pro Thr Ser His Val Ala Ala Val Leu Ala Ser Leu Leu Val 
        115                 120                 125             


Leu Leu Ala Leu Leu Leu Ala Ala Leu Leu Tyr Val Lys Cys Arg Leu 
    130                 135                 140                 


Asn Val Leu Leu Trp Tyr Gln Asp Ala Tyr Gly Glu Val Glu Ile Asn 
145                 150                 155                 160 


Asp Gly Lys Leu Tyr Asp Ala Tyr Val Ser Tyr Ser Asp Cys Pro Glu 
                165                 170                 175     


Asp Arg Lys Phe Val Asn Phe Ile Leu Lys Pro Gln Leu Glu Arg Arg 
            180                 185                 190         


Arg Gly Tyr Lys Leu Phe Leu Asp Asp Arg Asp Leu Leu Pro Arg Ala 
        195                 200                 205             


Glu Pro Ser Ala Asp Leu Leu Val Asn Leu Ser Arg Cys Arg Arg Leu 
    210                 215                 220                 


Ile Val Val Leu Ser Asp Ala Phe Leu Ser Arg Ala Trp Cys Ser His 
225                 230                 235                 240 


Ser Phe Arg Glu Gly Leu Cys Arg Leu Leu Glu Leu Thr Arg Arg Pro 
                245                 250                 255     


Ile Phe Ile Thr Phe Glu Gly Gln Arg Arg Asp Pro Ala His Pro Ala 
            260                 265                 270         


Leu Arg Leu Leu Arg Gln His Arg His Leu Val Thr Leu Leu Leu Trp 
        275                 280                 285             


Arg Pro Gly Ser Val Thr Pro Ser Ser Asp Phe Trp Lys Glu Val Gln 
    290                 295                 300                 


Leu Ala Leu Pro Arg Lys Val Gln Tyr Arg Pro Val Glu Gly Asp Pro 
305                 310                 315                 320 


Gln Thr Gln Leu Gln Asp Asp Lys Asp Pro Met Leu Ile Leu Arg Gly 
                325                 330                 335     


Arg Val Pro Glu Gly Arg Ala Leu Asp Ser Glu Val Asp Pro Asp Pro 
            340                 345                 350         


Glu Gly Asp Leu Gly Val Arg Gly Pro Val Phe Gly Glu Pro Ser Ala 
        355                 360                 365             


Pro Pro His Thr Ser Gly Val Ser Leu Gly Glu Ser Arg Ser Ser Glu 
    370                 375                 380                 


Val Asp Val Ser Asp Leu Gly Ser Arg Asn Tyr Ser Ala Arg Thr Asp 
385                 390                 395                 400 


Phe Tyr Cys Leu Val Ser Lys Asp Asp Met 
                405                 410 


<210>  1517
<211>  587
<212>  PRT
<213>  Homo sapiens

<400>  1517

Met Pro Leu Asp Lys Ala Met Pro Leu Lys His Tyr Leu Leu Leu Leu 
1               5                   10                  15      


Val Gly Cys Gln Ala Trp Gly Ala Gly Leu Ala Tyr His Gly Cys Pro 
            20                  25                  30          


Ser Glu Cys Thr Cys Ser Arg Ala Ser Gln Val Glu Cys Thr Gly Ala 
        35                  40                  45              


Arg Ile Val Ala Val Pro Thr Pro Leu Pro Trp Asn Ala Met Ser Leu 
    50                  55                  60                  


Gln Ile Leu Asn Thr His Ile Thr Glu Leu Asn Glu Ser Pro Phe Leu 
65                  70                  75                  80  


Asn Ile Ser Ala Leu Ile Ala Leu Arg Ile Glu Lys Asn Glu Leu Ser 
                85                  90                  95      


Arg Ile Thr Pro Gly Ala Phe Arg Asn Leu Gly Ser Leu Arg Tyr Leu 
            100                 105                 110         


Ser Leu Ala Asn Asn Lys Leu Gln Val Leu Pro Ile Gly Leu Phe Gln 
        115                 120                 125             


Gly Leu Asp Ser Leu Glu Ser Leu Leu Leu Ser Ser Asn Gln Leu Leu 
    130                 135                 140                 


Gln Ile Gln Pro Ala His Phe Ser Gln Cys Ser Asn Leu Lys Glu Leu 
145                 150                 155                 160 


Gln Leu His Gly Asn His Leu Glu Tyr Ile Pro Asp Gly Ala Phe Asp 
                165                 170                 175     


His Leu Val Gly Leu Thr Lys Leu Asn Leu Gly Lys Asn Ser Leu Thr 
            180                 185                 190         


His Ile Ser Pro Arg Val Phe Gln His Leu Gly Asn Leu Gln Val Leu 
        195                 200                 205             


Arg Leu Tyr Glu Asn Arg Leu Thr Asp Ile Pro Met Gly Thr Phe Asp 
    210                 215                 220                 


Gly Leu Val Asn Leu Gln Glu Leu Ala Leu Gln Gln Asn Gln Ile Gly 
225                 230                 235                 240 


Leu Leu Ser Pro Gly Leu Phe His Asn Asn His Asn Leu Gln Arg Leu 
                245                 250                 255     


Tyr Leu Ser Asn Asn His Ile Ser Gln Leu Pro Pro Ser Val Phe Met 
            260                 265                 270         


Gln Leu Pro Gln Leu Asn Arg Leu Thr Leu Phe Gly Asn Ser Leu Lys 
        275                 280                 285             


Glu Leu Ser Pro Gly Ile Phe Gly Pro Met Pro Asn Leu Arg Glu Leu 
    290                 295                 300                 


Trp Leu Tyr Asp Asn His Ile Ser Ser Leu Pro Asp Asn Val Phe Ser 
305                 310                 315                 320 


Asn Leu Arg Gln Leu Gln Val Leu Ile Leu Ser Arg Asn Gln Ile Ser 
                325                 330                 335     


Phe Ile Ser Pro Gly Ala Phe Asn Gly Leu Thr Glu Leu Arg Glu Leu 
            340                 345                 350         


Ser Leu His Thr Asn Ala Leu Gln Asp Leu Asp Gly Asn Val Phe Arg 
        355                 360                 365             


Met Leu Ala Asn Leu Gln Asn Ile Ser Leu Gln Asn Asn Arg Leu Arg 
    370                 375                 380                 


Gln Leu Pro Gly Asn Ile Phe Ala Asn Val Asn Gly Leu Met Ala Ile 
385                 390                 395                 400 


Gln Leu Gln Asn Asn Gln Leu Glu Asn Leu Pro Leu Gly Ile Phe Asp 
                405                 410                 415     


His Leu Gly Lys Leu Cys Glu Leu Arg Leu Tyr Asp Asn Pro Trp Arg 
            420                 425                 430         


Cys Asp Ser Asp Ile Leu Pro Leu Arg Asn Trp Leu Leu Leu Asn Gln 
        435                 440                 445             


Pro Arg Leu Gly Thr Asp Thr Val Pro Val Cys Phe Ser Pro Ala Asn 
    450                 455                 460                 


Val Arg Gly Gln Ser Leu Ile Ile Ile Asn Val Asn Val Ala Val Pro 
465                 470                 475                 480 


Ser Val His Val Pro Glu Val Pro Ser Tyr Pro Glu Thr Pro Trp Tyr 
                485                 490                 495     


Pro Asp Thr Pro Ser Tyr Pro Asp Thr Thr Ser Val Ser Ser Thr Thr 
            500                 505                 510         


Glu Leu Thr Ser Pro Val Glu Asp Tyr Thr Asp Leu Thr Thr Ile Gln 
        515                 520                 525             


Val Thr Asp Asp Arg Ser Val Trp Gly Met Thr Gln Ala Gln Ser Gly 
    530                 535                 540                 


Leu Ala Ile Ala Ala Ile Val Ile Gly Ile Val Ala Leu Ala Cys Ser 
545                 550                 555                 560 


Leu Ala Ala Cys Val Gly Cys Cys Cys Cys Lys Lys Arg Ser Gln Ala 
                565                 570                 575     


Val Leu Met Gln Met Lys Ala Pro Asn Glu Cys 
            580                 585         


<210>  1518
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  1518

Met Gly Ile Ile Gln Ser Ile Leu Ala Thr Ser Arg Asp Cys Tyr Ser 
1               5                   10                  15      


Phe Lys Lys Lys Pro Ile Pro Lys Lys Pro Thr Met Leu Ala Leu Ala 
            20                  25                  30          


Lys Ile Leu Leu Ile Ser Thr Leu Phe Tyr Ser Leu Leu Ser Gly Ser 
        35                  40                  45              


His Gly Lys Glu Asn Gln Asp Ile Asn Thr Thr Gln Asn Ile Ala Glu 
    50                  55                  60                  


Val Phe Lys Thr Met Glu Asn Lys Pro Ile Ser Leu Glu Ser Glu Ala 
65                  70                  75                  80  


Asn Leu Asn Ser Asp Lys Glu Asn Ile Thr Thr Ser Asn Leu Lys Ala 
                85                  90                  95      


Ser His Ser Pro Pro Leu Asn Leu Pro Asn Asn Ser His Gly Ile Thr 
            100                 105                 110         


Asp Phe Ser Ser Asn Ser Ser Ala Glu His Ser Leu Gly Ser Leu Lys 
        115                 120                 125             


Pro Thr Ser Thr Ile Ser Thr Ser Pro Pro Leu Ile His Ser Phe Val 
    130                 135                 140                 


Ser Lys Val Pro Trp Asn Ala Pro Ile Ala Asp Glu Asp Leu Leu Pro 
145                 150                 155                 160 


Ile Ser Ala His Pro Asn Ala Thr Pro Ala Leu Ser Ser Glu Asn Phe 
                165                 170                 175     


Thr Trp Ser Leu Val Asn Asp Thr Val Lys Thr Pro Asp Asn Ser Ser 
            180                 185                 190         


Ile Thr Val Ser Ile Leu Ser Ser Glu Pro Thr Ser Pro Ser Val Thr 
        195                 200                 205             


Pro Leu Ile Val Glu Pro Ser Gly Trp Leu Thr Thr Asn Ser Asp Ser 
    210                 215                 220                 


Phe Thr Gly Phe Thr Pro Tyr Gln Glu Lys Thr Thr Leu Gln Pro Thr 
225                 230                 235                 240 


Leu Lys Phe Thr Asn Asn Ser Lys Leu Phe Pro Asn Thr Ser Asp Pro 
                245                 250                 255     


Gln Lys Glu Asn Arg Asn Thr Gly Ile Val Phe Gly Ala Ile Leu Gly 
            260                 265                 270         


Ala Ile Leu Gly Val Ser Leu Leu Thr Leu Val Gly Tyr Leu Leu Cys 
        275                 280                 285             


Gly Lys Arg Lys Thr Asp Ser Phe Ser His Arg Arg Leu Tyr Asp Asp 
    290                 295                 300                 


Arg Asn Glu Pro Val Leu Arg Leu Asp Asn Ala Pro Glu Pro Tyr Asp 
305                 310                 315                 320 


Val Ser Phe Gly Asn Ser Ser Tyr Tyr Asn Pro Thr Leu Asn Asp Ser 
                325                 330                 335     


Ala Met Pro Glu Ser Glu Glu Asn Ala Arg Asp Gly Ile Pro Met Asp 
            340                 345                 350         


Asp Ile Pro Pro Leu Arg Thr Ser Val 
        355                 360     


<210>  1519
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  1519

Met Gly Ile Ile Gln Ser Ile Leu Ala Thr Ser Arg Asp Cys Tyr Ser 
1               5                   10                  15      


Phe Lys Lys Lys Pro Ile Pro Lys Lys Pro Thr Met Leu Ala Leu Ala 
            20                  25                  30          


Lys Ile Leu Leu Ile Ser Thr Leu Phe Tyr Ser Leu Leu Ser Gly Ser 
        35                  40                  45              


His Gly Lys Glu Asn Gln Asp Ile Asn Thr Thr Gln Asn Ile Ala Glu 
    50                  55                  60                  


Val Phe Lys Thr Met Glu Asn Lys Pro Ile Ser Leu Glu Ser Glu Ala 
65                  70                  75                  80  


Asn Leu Asn Ser Asp Lys Glu Asn Ile Thr Thr Ser Asn Leu Lys Ala 
                85                  90                  95      


Ser His Ser Pro Pro Leu Asn Leu Pro Asn Asn Ser His Gly Ile Thr 
            100                 105                 110         


Asp Phe Ser Ser Asn Ser Ser Ala Glu His Ser Leu Gly Ser Leu Lys 
        115                 120                 125             


Pro Thr Ser Thr Ile Ser Thr Ser Pro Pro Leu Ile His Ser Phe Val 
    130                 135                 140                 


Ser Lys Val Pro Trp Asn Ala Pro Ile Ala Asp Glu Asp Leu Leu Pro 
145                 150                 155                 160 


Ile Ser Ala His Pro Asn Ala Thr Pro Ala Leu Ser Ser Glu Asn Phe 
                165                 170                 175     


Thr Trp Ser Leu Val Asn Asp Thr Val Lys Thr Pro Asp Asn Ser Ser 
            180                 185                 190         


Ile Thr Val Ser Ile Leu Ser Ser Glu Pro Thr Ser Pro Ser Val Thr 
        195                 200                 205             


Pro Leu Ile Val Glu Pro Ser Gly Trp Leu Thr Thr Asn Ser Asp Ser 
    210                 215                 220                 


Phe Thr Gly Phe Thr Pro Tyr Gln Glu Lys Thr Thr Leu Gln Pro Thr 
225                 230                 235                 240 


Leu Lys Phe Thr Asn Asn Ser Lys Leu Phe Pro Asn Thr Ser Asp Pro 
                245                 250                 255     


Gln Lys Val Leu Arg Leu Asp Asn Ala Pro Glu Pro Tyr Asp Val Ser 
            260                 265                 270         


Phe Gly Asn Ser Ser Tyr Tyr Asn Pro Thr Leu Asn Asp Ser Ala Met 
        275                 280                 285             


Pro Glu Ser Glu Glu Asn Ala Arg Asp Gly Ile Pro Met Asp Asp Ile 
    290                 295                 300                 


Pro Pro Leu Arg Thr Ser Val 
305                 310     


<210>  1520
<211>  1204
<212>  PRT
<213>  Homo sapiens

<400>  1520

Met Tyr Val Thr Met Met Met Thr Asp Gln Ile Pro Leu Glu Leu Pro 
1               5                   10                  15      


Pro Leu Leu Asn Gly Glu Val Ala Met Met Pro His Leu Val Asn Gly 
            20                  25                  30          


Asp Ala Ala Gln Gln Val Ile Leu Val Gln Val Asn Pro Gly Glu Thr 
        35                  40                  45              


Phe Thr Ile Arg Ala Glu Asp Gly Thr Leu Gln Cys Ile Gln Gly Pro 
    50                  55                  60                  


Ala Glu Val Pro Met Met Ser Pro Asn Gly Ser Ile Pro Pro Ile His 
65                  70                  75                  80  


Val Pro Pro Gly Tyr Ile Ser Gln Val Ile Glu Asp Ser Thr Gly Val 
                85                  90                  95      


Arg Arg Val Val Val Thr Pro Gln Ser Pro Glu Cys Tyr Pro Pro Ser 
            100                 105                 110         


Tyr Pro Ser Ala Met Ser Pro Thr His His Leu Pro Pro Tyr Leu Thr 
        115                 120                 125             


His His Pro His Phe Ile His Asn Ser His Thr Ala Tyr Tyr Pro Pro 
    130                 135                 140                 


Val Thr Gly Pro Gly Asp Met Pro Pro Gln Phe Phe Pro Gln His His 
145                 150                 155                 160 


Leu Pro His Thr Ile Tyr Gly Glu Gln Glu Ile Ile Pro Phe Tyr Gly 
                165                 170                 175     


Met Ser Thr Tyr Ile Thr Arg Glu Asp Gln Tyr Ser Lys Pro Pro His 
            180                 185                 190         


Lys Lys Leu Lys Asp Arg Gln Ile Asp Arg Gln Asn Arg Leu Asn Ser 
        195                 200                 205             


Pro Pro Ser Ser Ile Tyr Lys Ser Ser Cys Thr Thr Val Tyr Asn Gly 
    210                 215                 220                 


Tyr Gly Lys Gly His Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser 
225                 230                 235                 240 


Gly Pro Gly Ile Lys Lys Thr Glu Arg Arg Ala Arg Ser Ser Pro Lys 
                245                 250                 255     


Ser Asn Asp Ser Asp Leu Gln Glu Tyr Glu Leu Glu Val Lys Arg Val 
            260                 265                 270         


Gln Asp Ile Leu Ser Gly Ile Glu Lys Pro Gln Val Ser Asn Ile Gln 
        275                 280                 285             


Ala Arg Ala Val Val Leu Ser Trp Ala Pro Pro Val Gly Leu Ser Cys 
    290                 295                 300                 


Gly Pro His Ser Gly Leu Ser Phe Pro Tyr Ser Tyr Glu Val Ala Leu 
305                 310                 315                 320 


Ser Asp Lys Gly Arg Asp Gly Lys Tyr Lys Ile Ile Tyr Ser Gly Glu 
                325                 330                 335     


Glu Leu Glu Cys Asn Leu Lys Asp Leu Arg Pro Ala Thr Asp Tyr His 
            340                 345                 350         


Val Arg Val Tyr Ala Met Tyr Asn Ser Val Lys Gly Ser Cys Ser Glu 
        355                 360                 365             


Pro Val Ser Phe Thr Thr His Ser Cys Ala Pro Glu Cys Pro Phe Pro 
    370                 375                 380                 


Pro Lys Leu Ala His Arg Ser Lys Ser Ser Leu Thr Leu Gln Trp Lys 
385                 390                 395                 400 


Ala Pro Ile Asp Asn Gly Ser Lys Ile Thr Asn Tyr Leu Leu Glu Trp 
                405                 410                 415     


Asp Glu Gly Lys Arg Asn Ser Gly Phe Arg Gln Cys Phe Phe Gly Ser 
            420                 425                 430         


Gln Lys His Cys Lys Leu Thr Lys Leu Cys Pro Ala Met Gly Tyr Thr 
        435                 440                 445             


Phe Arg Leu Ala Ala Arg Asn Asp Ile Gly Thr Ser Gly Tyr Ser Gln 
    450                 455                 460                 


Glu Val Val Cys Tyr Thr Leu Gly Asn Ile Pro Gln Met Pro Ser Ala 
465                 470                 475                 480 


Pro Arg Leu Val Arg Ala Gly Ile Thr Trp Val Thr Leu Gln Trp Ser 
                485                 490                 495     


Lys Pro Glu Gly Cys Ser Pro Glu Glu Val Ile Thr Tyr Thr Leu Glu 
            500                 505                 510         


Ile Gln Glu Asp Glu Asn Asp Asn Leu Phe His Pro Lys Tyr Thr Gly 
        515                 520                 525             


Glu Asp Leu Thr Cys Thr Val Lys Asn Leu Lys Arg Ser Thr Gln Tyr 
    530                 535                 540                 


Lys Phe Arg Leu Thr Ala Ser Asn Thr Glu Gly Lys Ser Cys Pro Ser 
545                 550                 555                 560 


Glu Val Leu Val Cys Thr Thr Ser Pro Asp Arg Pro Gly Pro Pro Thr 
                565                 570                 575     


Arg Pro Leu Val Lys Gly Pro Val Thr Ser His Gly Phe Ser Val Lys 
            580                 585                 590         


Trp Asp Pro Pro Lys Asp Asn Gly Gly Ser Glu Ile Leu Lys Tyr Leu 
        595                 600                 605             


Leu Glu Ile Thr Asp Gly Asn Ser Glu Ala Asn Gln Trp Glu Val Ala 
    610                 615                 620                 


Tyr Ser Gly Ser Ala Thr Glu Tyr Thr Phe Thr His Leu Lys Pro Gly 
625                 630                 635                 640 


Thr Leu Tyr Lys Leu Arg Ala Cys Cys Ile Ser Thr Gly Gly His Ser 
                645                 650                 655     


Gln Cys Ser Glu Ser Leu Pro Val Arg Thr Leu Ser Ile Ala Pro Gly 
            660                 665                 670         


Gln Cys Arg Pro Pro Arg Val Leu Gly Arg Pro Lys His Lys Glu Val 
        675                 680                 685             


His Leu Glu Trp Asp Val Pro Ala Ser Glu Ser Gly Cys Glu Val Ser 
    690                 695                 700                 


Glu Tyr Ser Val Glu Met Thr Glu Pro Glu Asp Val Ala Ser Glu Val 
705                 710                 715                 720 


Tyr His Gly Pro Glu Leu Glu Cys Thr Val Gly Asn Leu Leu Pro Gly 
                725                 730                 735     


Thr Val Tyr Arg Phe Arg Val Arg Ala Leu Asn Asp Gly Gly Tyr Gly 
            740                 745                 750         


Pro Tyr Ser Asp Val Ser Glu Ile Thr Thr Ala Ala Gly Pro Pro Gly 
        755                 760                 765             


Gln Cys Lys Ala Pro Cys Ile Ser Cys Thr Pro Asp Gly Cys Val Leu 
    770                 775                 780                 


Val Gly Trp Glu Ser Pro Asp Ser Ser Gly Ala Asp Ile Ser Glu Tyr 
785                 790                 795                 800 


Arg Leu Glu Trp Gly Glu Asp Glu Glu Ser Leu Glu Leu Ile Tyr His 
                805                 810                 815     


Gly Thr Asp Thr Arg Phe Glu Ile Arg Asp Leu Leu Pro Ala Ala Gln 
            820                 825                 830         


Tyr Cys Cys Arg Leu Gln Ala Phe Asn Gln Ala Gly Ala Gly Pro Tyr 
        835                 840                 845             


Ser Glu Leu Val Leu Cys Gln Thr Pro Ala Ser Ala Pro Asp Pro Val 
    850                 855                 860                 


Ser Thr Leu Cys Val Leu Glu Glu Glu Pro Leu Asp Ala Tyr Pro Asp 
865                 870                 875                 880 


Ser Pro Ser Ala Cys Leu Val Leu Asn Trp Glu Glu Pro Cys Asn Asn 
                885                 890                 895     


Gly Ser Glu Ile Leu Ala Tyr Thr Ile Asp Leu Gly Asp Thr Ser Ile 
            900                 905                 910         


Thr Val Gly Asn Thr Thr Met His Val Met Lys Asp Leu Leu Pro Glu 
        915                 920                 925             


Thr Thr Tyr Arg Ile Arg Ile Gln Ala Ile Asn Glu Ile Gly Ala Gly 
    930                 935                 940                 


Pro Phe Ser Gln Phe Ile Lys Ala Lys Thr Arg Pro Leu Pro Pro Leu 
945                 950                 955                 960 


Pro Pro Arg Leu Glu Cys Ala Ala Ala Gly Pro Gln Ser Leu Lys Leu 
                965                 970                 975     


Lys Trp Gly Asp Ser Asn Ser Lys Thr His Ala Ala Glu Asp Ile Val 
            980                 985                 990         


Tyr Thr Leu Gln Leu Glu Asp Arg  Asn Lys Arg Phe Ile  Ser Ile Tyr 
        995                 1000                 1005             


Arg Gly  Pro Ser His Thr Tyr  Lys Val Gln Arg Leu  Thr Glu Phe 
    1010                 1015                 1020             


Thr Cys  Tyr Ser Phe Arg Ile  Gln Ala Ala Ser Glu  Ala Gly Glu 
    1025                 1030                 1035             


Gly Pro  Phe Ser Glu Thr Tyr  Thr Phe Ser Thr Thr  Lys Ser Val 
    1040                 1045                 1050             


Pro Pro  Thr Ile Lys Ala Pro  Arg Val Thr Gln Leu  Glu Gly Asn 
    1055                 1060                 1065             


Ser Cys  Glu Ile Leu Trp Glu  Thr Val Pro Ser Met  Lys Gly Asp 
    1070                 1075                 1080             


Pro Val  Asn Tyr Ile Leu Gln  Val Leu Val Gly Arg  Glu Ser Glu 
    1085                 1090                 1095             


Tyr Lys  Gln Val Tyr Lys Gly  Glu Glu Ala Thr Phe  Gln Ile Ser 
    1100                 1105                 1110             


Gly Leu  Gln Thr Asn Thr Asp  Tyr Arg Phe Arg Val  Cys Ala Cys 
    1115                 1120                 1125             


Arg Arg  Cys Leu Asp Thr Ser  Gln Glu Leu Ser Gly  Ala Phe Ser 
    1130                 1135                 1140             


Pro Ser  Ala Ala Phe Val Leu  Gln Arg Ser Glu Val  Met Leu Thr 
    1145                 1150                 1155             


Gly Asp  Met Gly Ser Leu Asp  Asp Pro Lys Met Lys  Ser Met Met 
    1160                 1165                 1170             


Pro Thr  Asp Glu Gln Phe Ala  Ala Ile Ile Val Leu  Gly Phe Ala 
    1175                 1180                 1185             


Thr Leu  Ser Ile Leu Phe Ala  Phe Ile Leu Gln Tyr  Phe Leu Met 
    1190                 1195                 1200             


Lys 
    


<210>  1521
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  1521

Met Pro Pro Ala Pro Pro Gly Gly Glu Ser Gly Cys Glu Glu Arg Gly 
1               5                   10                  15      


Ala Ala Gly His Ile Glu His Ser Arg Tyr Leu Ser Leu Leu Asp Ala 
            20                  25                  30          


Val Asp Asn Ser Lys Met Ala Leu Asn Ser Gly Ser Pro Pro Ala Ile 
        35                  40                  45              


Gly Pro Tyr Tyr Glu Asn His Gly Tyr Gln Pro Glu Asn Pro Tyr Pro 
    50                  55                  60                  


Ala Gln Pro Thr Val Val Pro Thr Val Tyr Glu Val His Pro Ala Gln 
65                  70                  75                  80  


Tyr Tyr Pro Ser Pro Val Pro Gln Tyr Ala Pro Arg Val Leu Thr Gln 
                85                  90                  95      


Ala Ser Asn Pro Val Val Cys Thr Gln Pro Lys Ser Pro Ser Gly Thr 
            100                 105                 110         


Val Cys Thr Ser Lys Thr Lys Lys Ala Leu Cys Ile Thr Leu Thr Leu 
        115                 120                 125             


Gly Thr Phe Leu Val Gly Ala Ala Leu Ala Ala Gly Leu Leu Trp Lys 
    130                 135                 140                 


Phe Met Gly Ser Lys Cys Ser Asn Ser Gly Ile Glu Cys Asp Ser Ser 
145                 150                 155                 160 


Gly Thr Cys Ile Asn Pro Ser Asn Trp Cys Asp Gly Val Ser His Cys 
                165                 170                 175     


Pro Gly Gly Glu Asp Glu Asn Arg Cys Val Arg Leu Tyr Gly Pro Asn 
            180                 185                 190         


Phe Ile Leu Gln Val Tyr Ser Ser Gln Arg Lys Ser Trp His Pro Val 
        195                 200                 205             


Cys Gln Asp Asp Trp Asn Glu Asn Tyr Gly Arg Ala Ala Cys Arg Asp 
    210                 215                 220                 


Met Gly Tyr Lys Asn Asn Phe Tyr Ser Ser Gln Gly Ile Val Asp Asp 
225                 230                 235                 240 


Ser Gly Ser Thr Ser Phe Met Lys Leu Asn Thr Ser Ala Gly Asn Val 
                245                 250                 255     


Asp Ile Tyr Lys Lys Leu Tyr His Ser Asp Ala Cys Ser Ser Lys Ala 
            260                 265                 270         


Val Val Ser Leu Arg Cys Ile Ala Cys Gly Val Asn Leu Asn Ser Ser 
        275                 280                 285             


Arg Gln Ser Arg Ile Val Gly Gly Glu Ser Ala Leu Pro Gly Ala Trp 
    290                 295                 300                 


Pro Trp Gln Val Ser Leu His Val Gln Asn Val His Val Cys Gly Gly 
305                 310                 315                 320 


Ser Ile Ile Thr Pro Glu Trp Ile Val Thr Ala Ala His Cys Val Glu 
                325                 330                 335     


Lys Pro Leu Asn Asn Pro Trp His Trp Thr Ala Phe Ala Gly Ile Leu 
            340                 345                 350         


Arg Gln Ser Phe Met Phe Tyr Gly Ala Gly Tyr Gln Val Glu Lys Val 
        355                 360                 365             


Ile Ser His Pro Asn Tyr Asp Ser Lys Thr Lys Asn Asn Asp Ile Ala 
    370                 375                 380                 


Leu Met Lys Leu Gln Lys Pro Leu Thr Phe Asn Asp Leu Val Lys Pro 
385                 390                 395                 400 


Val Cys Leu Pro Asn Pro Gly Met Met Leu Gln Pro Glu Gln Leu Cys 
                405                 410                 415     


Trp Ile Ser Gly Trp Gly Ala Thr Glu Glu Lys Gly Lys Thr Ser Glu 
            420                 425                 430         


Val Leu Asn Ala Ala Lys Val Leu Leu Ile Glu Thr Gln Arg Cys Asn 
        435                 440                 445             


Ser Arg Tyr Val Tyr Asp Asn Leu Ile Thr Pro Ala Met Ile Cys Ala 
    450                 455                 460                 


Gly Phe Leu Gln Gly Asn Val Asp Ser Cys Gln Gly Asp Ser Gly Gly 
465                 470                 475                 480 


Pro Leu Val Thr Ser Lys Asn Asn Ile Trp Trp Leu Ile Gly Asp Thr 
                485                 490                 495     


Ser Trp Gly Ser Gly Cys Ala Lys Ala Tyr Arg Pro Gly Val Tyr Gly 
            500                 505                 510         


Asn Val Met Val Phe Thr Asp Trp Ile Tyr Arg Gln Met Arg Ala Asp 
        515                 520                 525             


Gly 
    


<210>  1522
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  1522

Met Pro Ser Ala Gly Leu Cys Ser Cys Trp Gly Gly Arg Val Leu Pro 
1               5                   10                  15      


Leu Leu Leu Ala Tyr Val Cys Tyr Leu Leu Leu Gly Ala Thr Ile Phe 
            20                  25                  30          


Gln Leu Leu Glu Arg Gln Ala Glu Ala Gln Ser Arg Asp Gln Phe Gln 
        35                  40                  45              


Leu Glu Lys Leu Arg Phe Leu Glu Asn Tyr Thr Cys Leu Asp Gln Trp 
    50                  55                  60                  


Ala Met Glu Gln Phe Val Gln Val Ile Met Glu Ala Trp Val Lys Gly 
65                  70                  75                  80  


Val Asn Pro Lys Gly Asn Ser Thr Asn Pro Ser Asn Trp Asp Phe Gly 
                85                  90                  95      


Ser Ser Phe Phe Phe Ala Gly Thr Val Val Thr Thr Ile Gly Tyr Gly 
            100                 105                 110         


Asn Leu Ala Pro Ser Thr Glu Ala Gly Gln Val Phe Cys Val Phe Tyr 
        115                 120                 125             


Ala Leu Leu Gly Ile Pro Leu Asn Val Ile Phe Leu Asn His Leu Gly 
    130                 135                 140                 


Thr Gly Leu Arg Ala His Leu Ala Ala Ile Glu Arg Trp Glu Asp Arg 
145                 150                 155                 160 


Pro Arg Arg Ser Gln Val Leu Gln Val Leu Gly Leu Ala Leu Phe Leu 
                165                 170                 175     


Thr Leu Gly Thr Leu Val Ile Leu Ile Phe Pro Pro Met Val Phe Ser 
            180                 185                 190         


His Val Glu Gly Trp Ser Phe Ser Glu Gly Phe Tyr Phe Ala Phe Ile 
        195                 200                 205             


Thr Leu Ser Thr Ile Gly Phe Gly Asp Tyr Val Val Gly His Pro Leu 
    210                 215                 220                 


Asn Phe Ile Thr Pro Ser Gly Leu Leu Pro Ser Gln Glu Pro Phe Gln 
225                 230                 235                 240 


Thr Pro His Gly Lys Pro Glu Ser Gln Gln Ile Pro Gly Ser Phe Gln 
                245                 250                 255     


Lys Val Ser Ser Met Asn Val Trp Pro Leu Ser Gly Met His Ser Pro 
            260                 265                 270         


Gly Leu Ala Phe Pro Leu Pro Asp Cys Asn Ile Pro Asp Gln Glu Arg 
        275                 280                 285             


Phe Arg Pro Leu His Pro Gly Ala Trp Lys Phe Trp Pro Leu Pro Leu 
    290                 295                 300                 


Pro Ser Ser Asn Ser Lys Trp Ala Pro Met Trp Leu Gly Ser Ser Ala 
305                 310                 315                 320 


Gln Val 
        


<210>  1523
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  1523

Met Pro Ser Ala Gly Leu Cys Ser Cys Trp Gly Gly Arg Val Leu Pro 
1               5                   10                  15      


Leu Leu Leu Ala Tyr Val Cys Tyr Leu Leu Leu Gly Ala Thr Ile Phe 
            20                  25                  30          


Gln Leu Leu Glu Arg Gln Ala Glu Ala Gln Ser Arg Asp Gln Phe Gln 
        35                  40                  45              


Leu Glu Lys Leu Arg Phe Leu Glu Asn Tyr Thr Cys Leu Asp Gln Trp 
    50                  55                  60                  


Ala Met Glu Gln Phe Val Gln Val Ile Met Glu Ala Trp Val Lys Gly 
65                  70                  75                  80  


Val Asn Pro Lys Gly Asn Ser Thr Asn Pro Ser Asn Trp Asp Phe Gly 
                85                  90                  95      


Ser Ser Phe Phe Phe Ala Gly Thr Val Val Thr Thr Ile Gly Tyr Gly 
            100                 105                 110         


Asn Leu Ala Pro Ser Thr Glu Ala Gly Gln Val Phe Cys Val Phe Tyr 
        115                 120                 125             


Ala Leu Leu Gly Ile Pro Leu Asn Val Ile Phe Leu Asn His Leu Gly 
    130                 135                 140                 


Thr Gly Leu Arg Ala His Leu Ala Ala Ile Glu Arg Trp Glu Asp Arg 
145                 150                 155                 160 


Pro Arg Arg Ser Gln Val Leu Gln Val Leu Gly Leu Ala Leu Phe Leu 
                165                 170                 175     


Thr Leu Gly Thr Leu Val Ile Leu Ile Phe Pro Pro Met Val Phe Ser 
            180                 185                 190         


His Val Glu Gly Trp Ser Phe Ser Glu Gly Phe Tyr Phe Ala Phe Ile 
        195                 200                 205             


Thr Leu Ser Thr Ile Gly Phe Gly Asp Tyr Val Val Gly Thr Asp Pro 
    210                 215                 220                 


Ser Lys His Tyr Ile Ser Val Tyr Arg Ser Leu Ala Ala Ile Trp Ile 
225                 230                 235                 240 


Leu Leu Gly Leu Ala Trp Leu Ala Leu Ile Leu Pro Leu Gly Pro Leu 
                245                 250                 255     


Leu Leu His Arg Cys Cys Gln Leu Trp Leu Leu Ser Arg Gly Leu Gly 
            260                 265                 270         


Val Lys Asp Gly Ala Ala Ser Asp Pro Ser Gly Leu Pro Arg Pro Gln 
        275                 280                 285             


Lys Ile Pro Ile Ser Ala 
    290                 


<210>  1524
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  1524

Met Pro Ser Ala Gly Leu Cys Ser Cys Trp Gly Gly Arg Val Leu Pro 
1               5                   10                  15      


Leu Leu Leu Ala Tyr Val Cys Tyr Leu Leu Leu Gly Ala Thr Ile Phe 
            20                  25                  30          


Gln Leu Leu Glu Arg Gln Ala Glu Ala Gln Ser Arg Asp Gln Phe Gln 
        35                  40                  45              


Leu Glu Lys Leu Arg Phe Leu Glu Asn Tyr Thr Cys Leu Asp Gln Trp 
    50                  55                  60                  


Ala Met Glu Gln Phe Val Gln Val Ile Met Glu Ala Trp Val Lys Gly 
65                  70                  75                  80  


Val Asn Pro Lys Gly Asn Ser Thr Asn Pro Ser Asn Trp Asp Phe Gly 
                85                  90                  95      


Ser Ser Phe Phe Phe Ala Gly Thr Val Val Thr Thr Ile Gly Tyr Gly 
            100                 105                 110         


Asn Leu Ala Pro Ser Thr Glu Ala Gly Gln Val Phe Cys Val Phe Tyr 
        115                 120                 125             


Ala Leu Leu Gly Ile Pro Leu Asn Val Ile Phe Leu Asn His Leu Gly 
    130                 135                 140                 


Thr Gly Leu Arg Ala His Leu Ala Ala Ile Glu Arg Trp Glu Asp Arg 
145                 150                 155                 160 


Pro Arg Arg Ser Gln Val Leu Gln Val Leu Gly Leu Ala Leu Phe Leu 
                165                 170                 175     


Thr Leu Gly Thr Leu Val Ile Leu Ile Phe Pro Pro Met Val Phe Ser 
            180                 185                 190         


His Val Glu Gly Trp Ser Phe Ser Glu Gly Phe Tyr Phe Ala Phe Ile 
        195                 200                 205             


Thr Leu Ser Thr Ile Gly Phe Gly Asp Tyr Val Val Gly Leu Arg Gln 
    210                 215                 220                 


Gly Cys Gly Ala Lys Ala Ala Pro Gly Arg Arg Pro Arg Arg Gly Ser 
225                 230                 235                 240 


Thr Ala Ala Arg Gly Val Gln Val Thr Pro Gln Asp Phe Pro Ile Ser 
                245                 250                 255     


Lys Lys Gly Leu Gly Ser 
            260         


<210>  1525
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  1525

Met Ala Tyr Ser Thr Val Gln Arg Val Ala Leu Ala Ser Gly Leu Val 
1               5                   10                  15      


Leu Ala Leu Ser Leu Leu Leu Pro Lys Ala Phe Leu Ser Arg Gly Lys 
            20                  25                  30          


Arg Gln Glu Pro Pro Pro Thr Pro Glu Gly Tyr Pro Glu Glu Thr Tyr 
        35                  40                  45              


Pro Ile Tyr Asp Leu Ser Asp Cys Ile Lys Arg Arg Gln Glu Thr Ile 
    50                  55                  60                  


Leu Val Asp Tyr Pro Asp Pro Lys Glu Leu Ser Ala Glu Glu Ile Ala 
65                  70                  75                  80  


Glu Arg Met Gly Met Ile Glu Glu Glu Glu Ser Asp His Leu Gly Trp 
                85                  90                  95      


Glu Ser Leu Pro Thr Asp Pro Arg Ala Gln Glu Asp Asn Ser Val Thr 
            100                 105                 110         


Ser Cys Asp Pro Lys Pro Glu Thr Cys Ser Cys Cys Phe His Glu Asp 
        115                 120                 125             


Glu Asp Pro Ala Val Leu Ala Glu Asn Ala Gly Phe Ser Ala Asp Ser 
    130                 135                 140                 


Tyr Pro Glu Gln Glu Glu Thr Thr Lys Glu Glu Trp Ser Gln Asp Phe 
145                 150                 155                 160 


Lys Asp Glu Gly Leu Gly Ile Ser Thr Asp Lys Ala Tyr Thr Gly Ser 
                165                 170                 175     


Met Leu Arg Lys Arg Asn Pro Gln Gly Leu Glu 
            180                 185         


<210>  1526
<211>  460
<212>  PRT
<213>  Homo sapiens

<400>  1526

Met Ala Pro Gly Arg Ala Val Ala Gly Leu Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Gly Leu Gly Gly Val Ala Glu Gly Pro Gly Leu Ala Phe Ser Glu Asp 
            20                  25                  30          


Val Leu Ser Val Phe Gly Ala Asn Leu Ser Leu Ser Ala Ala Gln Leu 
        35                  40                  45              


Gln His Leu Leu Glu Gln Met Gly Ala Ala Ser Arg Val Gly Val Pro 
    50                  55                  60                  


Glu Pro Gly Gln Leu His Phe Asn Gln Cys Leu Thr Ala Glu Glu Ile 
65                  70                  75                  80  


Phe Ser Leu His Gly Phe Ser Asn Ala Thr Gln Ile Thr Ser Ser Lys 
                85                  90                  95      


Phe Ser Val Ile Cys Pro Ala Val Leu Gln Gln Leu Asn Phe His Pro 
            100                 105                 110         


Cys Glu Asp Arg Pro Lys His Lys Thr Arg Pro Ser His Ser Glu Val 
        115                 120                 125             


Trp Gly Tyr Gly Phe Leu Ser Val Thr Ile Ile Asn Leu Ala Ser Leu 
    130                 135                 140                 


Leu Gly Leu Ile Leu Thr Pro Leu Ile Lys Lys Ser Tyr Phe Pro Lys 
145                 150                 155                 160 


Ile Leu Thr Phe Phe Val Gly Leu Ala Ile Gly Thr Leu Phe Ser Asn 
                165                 170                 175     


Ala Ile Phe Gln Leu Ile Pro Glu Ala Phe Gly Phe Asp Pro Lys Val 
            180                 185                 190         


Asp Ser Tyr Val Glu Lys Ala Val Ala Val Phe Gly Gly Phe Tyr Leu 
        195                 200                 205             


Leu Phe Phe Phe Glu Arg Met Leu Lys Met Leu Leu Lys Thr Tyr Gly 
    210                 215                 220                 


Gln Asn Gly His Thr His Phe Gly Asn Asp Asn Phe Gly Pro Gln Glu 
225                 230                 235                 240 


Lys Thr His Gln Pro Lys Ala Leu Pro Ala Ile Asn Gly Val Thr Cys 
                245                 250                 255     


Tyr Ala Asn Pro Ala Val Thr Glu Ala Asn Gly His Ile His Phe Asp 
            260                 265                 270         


Asn Val Ser Val Val Ser Leu Gln Asp Gly Lys Lys Glu Pro Ser Ser 
        275                 280                 285             


Cys Thr Cys Leu Lys Gly Pro Lys Leu Ser Glu Ile Gly Thr Ile Ala 
    290                 295                 300                 


Trp Met Ile Thr Leu Cys Asp Ala Leu His Asn Phe Ile Asp Gly Leu 
305                 310                 315                 320 


Ala Ile Gly Ala Ser Cys Thr Leu Ser Leu Leu Gln Gly Leu Ser Thr 
                325                 330                 335     


Ser Ile Ala Ile Leu Cys Glu Glu Phe Pro His Glu Leu Gly Asp Phe 
            340                 345                 350         


Val Ile Leu Leu Asn Ala Gly Met Ser Thr Arg Gln Ala Leu Leu Phe 
        355                 360                 365             


Asn Phe Leu Ser Ala Cys Ser Cys Tyr Val Gly Leu Ala Phe Gly Ile 
    370                 375                 380                 


Leu Val Gly Asn Asn Phe Ala Pro Asn Ile Ile Phe Ala Leu Ala Gly 
385                 390                 395                 400 


Gly Met Phe Leu Tyr Ile Ser Leu Ala Asp Met Phe Pro Glu Met Asn 
                405                 410                 415     


Asp Met Leu Arg Glu Lys Val Thr Gly Arg Lys Thr Asp Phe Thr Phe 
            420                 425                 430         


Phe Met Ile Gln Asn Ala Gly Met Leu Thr Gly Phe Thr Ala Ile Leu 
        435                 440                 445             


Leu Ile Thr Leu Tyr Ala Gly Glu Ile Glu Leu Glu 
    450                 455                 460 


<210>  1527
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  1527

Met Ala Pro Gly Arg Ala Val Ala Gly Leu Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Gly Leu Gly Gly Val Ala Glu Gly Pro Gly Leu Ala Phe Ser Glu Asp 
            20                  25                  30          


Val Leu Ser Val Phe Gly Ala Asn Leu Ser Leu Ser Ala Ala Gln Leu 
        35                  40                  45              


Gln His Leu Leu Glu Gln Met Gly Ala Ala Ser Arg Val Gly Val Pro 
    50                  55                  60                  


Glu Pro Gly Gln Leu His Phe Asn Gln Cys Leu Thr Ala Glu Glu Ile 
65                  70                  75                  80  


Phe Ser Leu His Gly Phe Ser Asn Ala Thr Gln Ile Thr Ser Ser Lys 
                85                  90                  95      


Phe Ser Val Ile Cys Pro Ala Val Leu Gln Gln Leu Asn Phe His Pro 
            100                 105                 110         


Cys Glu Asp Arg Pro Lys His Lys Thr Arg Pro Ser His Ser Glu Val 
        115                 120                 125             


Trp Gly Tyr Gly Phe Leu Ser Val Thr Ile Ile Asn Leu Ala Ser Leu 
    130                 135                 140                 


Leu Gly Leu Ile Leu Thr Pro Leu Ile Lys Lys Ser Tyr Phe Pro Lys 
145                 150                 155                 160 


Ile Leu Thr Phe Phe Val Gly Leu Ala Ile Gly Thr Leu Phe Ser Asn 
                165                 170                 175     


Ala Ile Phe Gln Leu Ile Pro Glu Ala Phe Gly Phe Asp Pro Lys Val 
            180                 185                 190         


Asp Ser Tyr Val Glu Lys Ala Val Ala Val Phe Gly Gly Phe Tyr Leu 
        195                 200                 205             


Leu Phe Phe Phe Glu Arg Met Leu Lys Met Leu Leu Lys Thr Tyr Gly 
    210                 215                 220                 


Gln Asn Gly His Thr His Phe Gly Asn Asp Asn Phe Gly Pro Gln Glu 
225                 230                 235                 240 


Lys Thr His Gln Pro Lys Ala Leu Pro Ala Ile Asn Gly Val Thr Cys 
                245                 250                 255     


Tyr Ala Asn Pro Ala Val Thr Glu Ala Asn Gly His Ile His Phe Asp 
            260                 265                 270         


Asn Val Ser Val Val Ser Leu Gln Asp Gly Lys Lys Glu Pro Ser Ser 
        275                 280                 285             


Cys Thr Cys Leu Lys Gly Pro Lys Leu Ser Glu Ile Gly Thr Ile Ala 
    290                 295                 300                 


Trp Met Ile Thr Leu Cys Asp Ala Leu His Asn Phe Ile Asp Gly Leu 
305                 310                 315                 320 


Ala Ile Gly Ala Ser Cys Thr Leu Ser Leu Leu Gln Gly Leu Ser Thr 
                325                 330                 335     


Ser Ile Ala Ile Leu Cys Glu Glu Phe Pro His Glu Leu Gly Asp Phe 
            340                 345                 350         


Val Ile Leu Leu Asn Ala Gly Met Ser Thr Arg Gln Ala Leu Leu Phe 
        355                 360                 365             


Asn Phe Leu Ser Ala Cys Ser Cys Tyr Val Gly Leu Ala Phe Gly Ile 
    370                 375                 380                 


Leu Val Gly Asn Asn Phe Ala Pro Asn Ile Ile Phe Ala Leu Ala Gly 
385                 390                 395                 400 


Gly Met Phe Leu Tyr Ile Ser Leu Ala Asp Met Phe Pro Glu Met Asn 
                405                 410                 415     


Asp Met Leu Arg Glu Lys Ile Ile Lys Trp Ala Thr Asp Asp Ile Lys 
            420                 425                 430         


Ser Gln Leu His Leu Leu Trp Ile Tyr Thr Ala Arg 
        435                 440                 


<210>  1528
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  1528

Met His Gln His Ala Gln Cys Leu Thr Ala Glu Glu Ile Phe Ser Leu 
1               5                   10                  15      


His Gly Phe Ser Asn Ala Thr Gln Ile Thr Ser Ser Lys Phe Ser Val 
            20                  25                  30          


Ile Cys Pro Ala Val Leu Gln Gln Leu Asn Phe His Pro Cys Glu Asp 
        35                  40                  45              


Arg Pro Lys His Lys Thr Arg Pro Ser His Ser Glu Val Trp Gly Tyr 
    50                  55                  60                  


Gly Phe Leu Ser Val Thr Ile Ile Asn Leu Ala Ser Leu Leu Gly Leu 
65                  70                  75                  80  


Ile Leu Thr Pro Leu Ile Lys Lys Ser Tyr Phe Pro Lys Ile Leu Thr 
                85                  90                  95      


Phe Phe Val Gly Leu Ala Ile Gly Thr Leu Phe Ser Asn Ala Ile Phe 
            100                 105                 110         


Gln Leu Ile Pro Glu Ala Phe Gly Phe Asp Pro Lys Val Asp Ser Tyr 
        115                 120                 125             


Val Glu Lys Ala Val Ala Val Phe Gly Gly Phe Tyr Leu Leu Phe Phe 
    130                 135                 140                 


Phe Glu Arg Met Leu Lys Met Leu Leu Lys Thr Tyr Gly Gln Asn Gly 
145                 150                 155                 160 


His Thr His Phe Gly Asn Asp Asn Phe Gly Pro Gln Glu Lys Thr His 
                165                 170                 175     


Gln Pro Lys Ala Leu Pro Ala Ile Asn Gly Val Thr Cys Tyr Ala Asn 
            180                 185                 190         


Pro Ala Val Thr Glu Ala Asn Gly His Ile His Phe Asp Asn Val Ser 
        195                 200                 205             


Val Val Ser Leu Gln Asp Gly Lys Lys Glu Pro Ser Ser Cys Thr Cys 
    210                 215                 220                 


Leu Lys Gly Pro Lys Leu Ser Glu Ile Gly Thr Ile Ala Trp Met Ile 
225                 230                 235                 240 


Thr Leu Cys Asp Ala Leu His Asn Phe Ile Asp Gly Leu Ala Ile Gly 
                245                 250                 255     


Ala Ser Cys Thr Leu Ser Leu Leu Gln Gly Leu Ser Thr Ser Ile Ala 
            260                 265                 270         


Ile Leu Cys Glu Glu Phe Pro His Glu Leu Gly Asp Phe Val Ile Leu 
        275                 280                 285             


Leu Asn Ala Gly Met Ser Thr Arg Gln Ala Leu Leu Phe Asn Phe Leu 
    290                 295                 300                 


Ser Ala Cys Ser Cys Tyr Val Gly Leu Ala Phe Gly Ile Leu Val Gly 
305                 310                 315                 320 


Asn Asn Phe Ala Pro Asn Ile Ile Phe Ala Leu Ala Gly Gly Met Phe 
                325                 330                 335     


Leu Tyr Ile Ser Leu Ala Asp Met Phe Pro Glu Met Asn Asp Met Leu 
            340                 345                 350         


Arg Glu Lys Val Thr Gly Arg Lys Thr Asp Phe Thr Phe Phe Met Ile 
        355                 360                 365             


Gln Asn Ala Gly Met Leu Thr Gly Phe Thr Ala Ile Leu Leu Ile Thr 
    370                 375                 380                 


Leu Tyr Ala Gly Glu Ile Glu Leu Glu 
385                 390             


<210>  1529
<211>  492
<212>  PRT
<213>  Homo sapiens

<400>  1529

Met Lys Leu Leu Leu Leu His Pro Ala Phe Gln Ser Cys Leu Leu Leu 
1               5                   10                  15      


Thr Leu Leu Gly Leu Trp Arg Thr Thr Pro Glu Ala His Ala Ser Ser 
            20                  25                  30          


Leu Gly Ala Pro Ala Ile Ser Ala Ala Ser Phe Leu Gln Asp Leu Ile 
        35                  40                  45              


His Arg Tyr Gly Glu Gly Asp Ser Leu Thr Leu Gln Gln Leu Lys Ala 
    50                  55                  60                  


Leu Leu Asn His Leu Asp Val Gly Val Gly Arg Gly Asn Val Thr Gln 
65                  70                  75                  80  


His Val Gln Gly His Arg Asn Leu Ser Thr Cys Phe Ser Ser Gly Asp 
                85                  90                  95      


Leu Phe Thr Ala His Asn Phe Ser Glu Gln Ser Arg Ile Gly Ser Ser 
            100                 105                 110         


Glu Leu Gln Glu Phe Cys Pro Thr Ile Leu Gln Gln Leu Asp Ser Arg 
        115                 120                 125             


Ala Cys Thr Ser Glu Asn Gln Glu Asn Glu Glu Asn Glu Gln Thr Glu 
    130                 135                 140                 


Glu Gly Arg Pro Ser Ala Val Glu Val Trp Gly Tyr Gly Leu Leu Cys 
145                 150                 155                 160 


Val Thr Val Ile Ser Leu Cys Ser Leu Leu Gly Ala Ser Val Val Pro 
                165                 170                 175     


Phe Met Lys Lys Thr Phe Tyr Lys Arg Leu Leu Leu Tyr Phe Ile Ala 
            180                 185                 190         


Leu Ala Ile Gly Thr Leu Tyr Ser Asn Ala Leu Phe Gln Leu Ile Pro 
        195                 200                 205             


Glu Ala Phe Gly Phe Asn Pro Leu Glu Asp Tyr Tyr Val Ser Lys Ser 
    210                 215                 220                 


Ala Val Val Phe Gly Gly Phe Tyr Leu Phe Phe Phe Thr Glu Lys Ile 
225                 230                 235                 240 


Leu Lys Ile Leu Leu Lys Gln Lys Asn Glu His His His Gly His Ser 
                245                 250                 255     


His Tyr Ala Ser Glu Ser Leu Pro Ser Lys Lys Asp Gln Glu Glu Gly 
            260                 265                 270         


Val Met Glu Lys Leu Gln Asn Gly Asp Leu Asp His Met Ile Pro Gln 
        275                 280                 285             


His Cys Ser Ser Glu Leu Asp Gly Lys Ala Pro Met Val Asp Glu Lys 
    290                 295                 300                 


Val Ile Val Gly Ser Leu Ser Val Gln Asp Leu Gln Ala Ser Gln Ser 
305                 310                 315                 320 


Ala Cys Tyr Trp Leu Lys Gly Val Arg Tyr Ser Asp Ile Gly Thr Leu 
                325                 330                 335     


Ala Trp Met Ile Thr Leu Ser Asp Gly Leu His Asn Phe Ile Asp Gly 
            340                 345                 350         


Leu Ala Ile Gly Ala Ser Phe Thr Val Ser Val Phe Gln Gly Ile Ser 
        355                 360                 365             


Thr Ser Val Ala Ile Leu Cys Glu Glu Phe Pro His Glu Leu Gly Asp 
    370                 375                 380                 


Phe Val Ile Leu Leu Asn Ala Gly Met Ser Ile Gln Gln Ala Leu Phe 
385                 390                 395                 400 


Phe Asn Phe Leu Ser Ala Cys Cys Cys Tyr Leu Gly Leu Ala Phe Gly 
                405                 410                 415     


Ile Leu Ala Gly Ser His Phe Ser Ala Asn Trp Ile Phe Ala Leu Ala 
            420                 425                 430         


Gly Gly Met Phe Leu Tyr Ile Ser Leu Ala Asp Met Phe Pro Glu Met 
        435                 440                 445             


Asn Glu Val Cys Gln Glu Asp Glu Arg Lys Gly Ser Ile Leu Ile Pro 
    450                 455                 460                 


Phe Ile Ile Gln Asn Leu Gly Leu Leu Thr Gly Phe Thr Ile Met Val 
465                 470                 475                 480 


Val Leu Thr Met Tyr Ser Gly Gln Ile Gln Ile Gly 
                485                 490         


<210>  1530
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  1530

Met Lys Leu Leu Leu Leu His Pro Ala Phe Gln Ser Cys Leu Leu Leu 
1               5                   10                  15      


Thr Leu Leu Gly Leu Trp Arg Thr Thr Pro Glu Ala His Ala Ser Ser 
            20                  25                  30          


Leu Gly Ala Pro Ala Ile Ser Ala Ala Ser Phe Leu Gln Asp Leu Ile 
        35                  40                  45              


His Arg Tyr Gly Glu Gly Asp Ser Leu Thr Leu Gln Gln Leu Lys Ala 
    50                  55                  60                  


Leu Leu Asn His Leu Asp Val Gly Val Gly Arg Gly Asn Val Thr Gln 
65                  70                  75                  80  


His Val Gln Gly His Arg Asn Leu Ser Thr Cys Phe Ser Ser Gly Asp 
                85                  90                  95      


Leu Phe Thr Ala His Asn Phe Ser Glu Gln Ser Arg Ile Gly Ser Ser 
            100                 105                 110         


Glu Leu Gln Glu Phe Cys Pro Thr Ile Leu Gln Gln Leu Asp Ser Arg 
        115                 120                 125             


Ala Cys Thr Ser Glu Asn Gln Glu Asn Glu Glu Asn Glu Gln Thr Glu 
    130                 135                 140                 


Glu Gly Arg Pro Ser Ala Val Glu Val Trp Gly Tyr Gly Leu Leu Cys 
145                 150                 155                 160 


Val Thr Val Ile Ser Leu Cys Ser Leu Leu Gly Ala Ser Val Val Pro 
                165                 170                 175     


Phe Met Lys Lys Thr Phe Tyr Lys Arg Leu Leu Leu Tyr Phe Ile Ala 
            180                 185                 190         


Leu Ala Ile Gly Thr Leu Tyr Ser Asn Ala Leu Phe Gln Leu Ile Pro 
        195                 200                 205             


Glu Ala Phe Gly Phe Asn Pro Leu Glu Asp Tyr Tyr Val Ser Lys Ser 
    210                 215                 220                 


Ala Val Val Phe Gly Gly Phe Tyr Leu Phe Phe Phe Thr Glu Lys Ile 
225                 230                 235                 240 


Leu Lys Ile Leu Leu Lys Gln Lys Asn Glu His His His Gly His Ser 
                245                 250                 255     


His Tyr Ala Ser Glu Ser Leu Pro Ser Lys Lys Asp Gln Glu Glu Gly 
            260                 265                 270         


Val Met Glu Lys Leu Gln Asn Gly Asp Leu Asp His Met Ile Pro Gln 
        275                 280                 285             


His Cys Ser Ser Glu Leu Asp Gly Lys Ala Pro Met Val Asp Glu Lys 
    290                 295                 300                 


Val Ile Val Gly Ser Leu Ser Val Gln Asp Leu Gln Ala Ser Gln Ser 
305                 310                 315                 320 


Ala Cys Tyr Trp Leu Lys Gly Val Arg Tyr Ser Asp Ile Gly Thr Leu 
                325                 330                 335     


Ala Trp Met Ile Thr Leu Ser Asp Gly Leu His Asn Phe Ile Asp Gly 
            340                 345                 350         


Leu Ala Ile Gly Ala Ser Phe Thr Val Ser Val Phe Gln Gly Ile Ser 
        355                 360                 365             


Thr Ser Val Ala Ile Leu Cys Glu Glu Phe Pro His Glu Leu Gly Asp 
    370                 375                 380                 


Phe Val Ile Leu Leu Asn Ala Gly Met Ser Ile Gln Gln Ala Leu Phe 
385                 390                 395                 400 


Phe Asn Phe Leu Ser Ala Cys Cys Cys Tyr Leu Gly Leu Ala Phe Gly 
                405                 410                 415     


Ile Leu Ala Gly Ser His Phe Ser Ala Asn Trp Ile Phe Ala Leu Ala 
            420                 425                 430         


Gly Gly Met Phe Leu Tyr Ile Ser Leu Ala Asp Met Met Glu Phe Cys 
        435                 440                 445             


Ser Val Ala Gln Ala Gly Val Gln Trp Cys His Leu Ser Ser Leu Gln 
    450                 455                 460                 


Pro Leu Pro Leu Gly Leu Lys Arg Leu Ser Cys Leu Ser Leu Pro Ser 
465                 470                 475                 480 


Asn 
    


<210>  1531
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  1531

Met Pro Glu Ala Pro Pro Leu Leu Leu Ala Ala Val Leu Leu Gly Leu 
1               5                   10                  15      


Val Leu Leu Val Val Leu Leu Leu Leu Leu Arg His Trp Gly Trp Gly 
            20                  25                  30          


Leu Cys Leu Ile Gly Trp Asn Glu Phe Ile Leu Gln Pro Ile His Asn 
        35                  40                  45              


Leu Leu Met Gly Asp Thr Lys Glu Gln Arg Ile Leu Asn His Val Leu 
    50                  55                  60                  


Gln His Ala Glu Pro Gly Asn Ala Gln Ser Val Leu Glu Ala Ile Asp 
65                  70                  75                  80  


Thr Tyr Cys Glu Gln Lys Glu Trp Ala Met Asn Val Gly Asp Lys Lys 
                85                  90                  95      


Gly Lys Ile Val Asp Ala Val Ile Gln Glu His Gln Pro Ser Val Leu 
            100                 105                 110         


Leu Glu Leu Gly Ala Tyr Cys Gly Tyr Ser Ala Val Arg Met Ala Arg 
        115                 120                 125             


Leu Leu Ser Pro Gly Ala Arg Leu Ile Thr Ile Glu Ile Asn Pro Asp 
    130                 135                 140                 


Cys Ala Ala Ile Thr Gln Arg Met Val Asp Phe Ala Gly Val Lys Asp 
145                 150                 155                 160 


Lys Val Thr Leu Val Val Gly Ala Ser Gln Asp Ile Ile Pro Gln Leu 
                165                 170                 175     


Lys Lys Lys Tyr Asp Val Asp Thr Leu Asp Met Val Phe Leu Asp His 
            180                 185                 190         


Trp Lys Asp Arg Tyr Leu Pro Asp Thr Leu Leu Leu Glu Glu Cys Gly 
        195                 200                 205             


Leu Leu Arg Lys Gly Thr Val Leu Leu Ala Asp Asn Val Ile Cys Pro 
    210                 215                 220                 


Gly Ala Pro Asp Phe Leu Ala His Val Arg Gly Ser Ser Cys Phe Glu 
225                 230                 235                 240 


Cys Thr His Tyr Gln Ser Phe Leu Glu Tyr Arg Glu Val Val Asp Gly 
                245                 250                 255     


Leu Glu Lys Ala Ile Tyr Lys Gly Pro Gly Ser Glu Ala Gly Pro 
            260                 265                 270     


<210>  1532
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  1532

Met Pro Glu Ala Pro Pro Leu Leu Leu Ala Ala Val Leu Leu Gly Leu 
1               5                   10                  15      


Val Leu Leu Val Val Leu Leu Leu Leu Leu Arg His Trp Gly Trp Gly 
            20                  25                  30          


Leu Cys Leu Ile Gly Trp Asn Glu Phe Ile Leu Gln Pro Ile His Asn 
        35                  40                  45              


Leu Leu Met Gly Asp Thr Lys Glu Gln Arg Ile Leu Asn His Val Leu 
    50                  55                  60                  


Gln His Ala Glu Pro Gly Asn Ala Gln Ser Val Leu Glu Ala Ile Asp 
65                  70                  75                  80  


Thr Tyr Cys Glu Gln Lys Glu Trp Ala Met Asn Val Gly Asp Lys Lys 
                85                  90                  95      


Gly Lys Ile Val Asp Ala Val Ile Gln Glu His Gln Pro Ser Val Leu 
            100                 105                 110         


Leu Glu Leu Gly Ala Tyr Cys Gly Tyr Ser Ala Val Arg Met Ala Arg 
        115                 120                 125             


Leu Leu Ser Pro Gly Ala Arg Leu Ile Thr Ile Glu Ile Asn Pro Asp 
    130                 135                 140                 


Cys Ala Ala Ile Thr Gln Arg Met Val Asp Phe Ala Gly Val Lys Asp 
145                 150                 155                 160 


Lys Val Thr Leu Val Val Gly Ala Ser Gln Asp Ile Ile Pro Gln Leu 
                165                 170                 175     


Lys Lys Lys Tyr Asp Val Asp Thr Leu Asp Met Val Phe Leu Asp His 
            180                 185                 190         


Trp Lys Asp Arg Tyr Leu Pro Asp Thr Leu Leu Leu Glu Glu Cys Gly 
        195                 200                 205             


Leu Leu Arg Lys Gly Thr Val Leu Leu Ala Asp Asn Val Ile Cys Pro 
    210                 215                 220                 


Gly Ala Pro Asp Phe Leu Ala His Val Arg Gly Ser Ser Cys Phe Glu 
225                 230                 235                 240 


Cys Thr His Tyr Gln Ser Phe Leu Glu Tyr Arg Glu Val Val Asp Gly 
                245                 250                 255     


Leu Glu Lys Ala Ile Tyr Lys Gly Pro Gly Ser Glu Ala Gly Pro 
            260                 265                 270     


<210>  1533
<211>  602
<212>  PRT
<213>  Homo sapiens

<400>  1533

Met Val Pro Gly Gln Ala Gln Pro Gln Ser Pro Glu Met Leu Leu Leu 
1               5                   10                  15      


Pro Leu Leu Leu Pro Val Leu Gly Ala Gly Ser Leu Asn Lys Asp Pro 
            20                  25                  30          


Ser Tyr Ser Leu Gln Val Gln Arg Gln Val Pro Val Pro Glu Gly Leu 
        35                  40                  45              


Cys Val Ile Val Ser Cys Asn Leu Ser Tyr Pro Arg Asp Gly Trp Asp 
    50                  55                  60                  


Glu Ser Thr Ala Ala Tyr Gly Tyr Trp Phe Lys Gly Arg Thr Ser Pro 
65                  70                  75                  80  


Lys Thr Gly Ala Pro Val Ala Thr Asn Asn Gln Ser Arg Glu Val Glu 
                85                  90                  95      


Met Ser Thr Arg Asp Arg Phe Gln Leu Thr Gly Asp Pro Gly Lys Gly 
            100                 105                 110         


Ser Cys Ser Leu Val Ile Arg Asp Ala Gln Arg Glu Asp Glu Ala Trp 
        115                 120                 125             


Tyr Phe Phe Arg Val Glu Arg Gly Ser Arg Val Arg His Ser Phe Leu 
    130                 135                 140                 


Ser Asn Ala Phe Phe Leu Lys Val Thr Ala Leu Thr Lys Lys Pro Asp 
145                 150                 155                 160 


Val Tyr Ile Pro Glu Thr Leu Glu Pro Gly Gln Pro Val Thr Val Ile 
                165                 170                 175     


Cys Val Phe Asn Trp Ala Phe Lys Lys Cys Pro Ala Pro Ser Phe Ser 
            180                 185                 190         


Trp Thr Gly Ala Ala Leu Ser Pro Arg Arg Thr Arg Pro Ser Thr Ser 
        195                 200                 205             


His Phe Ser Val Leu Ser Phe Thr Pro Ser Pro Gln Asp His Asp Thr 
    210                 215                 220                 


Asp Leu Thr Cys His Val Asp Phe Ser Arg Lys Gly Val Ser Ala Gln 
225                 230                 235                 240 


Arg Thr Val Arg Leu Arg Val Ala Tyr Ala Pro Lys Asp Leu Ile Ile 
                245                 250                 255     


Ser Ile Ser His Asp Asn Thr Ser Ala Leu Glu Leu Gln Gly Asn Val 
            260                 265                 270         


Ile Tyr Leu Glu Val Gln Lys Gly Gln Phe Leu Arg Leu Leu Cys Ala 
        275                 280                 285             


Ala Asp Ser Gln Pro Pro Ala Thr Leu Ser Trp Val Leu Gln Asp Arg 
    290                 295                 300                 


Val Leu Ser Ser Ser His Pro Trp Gly Pro Arg Thr Leu Gly Leu Glu 
305                 310                 315                 320 


Leu Arg Gly Val Arg Ala Gly Asp Ser Gly Arg Tyr Thr Cys Arg Ala 
                325                 330                 335     


Glu Asn Arg Leu Gly Ser Gln Gln Gln Ala Leu Asp Leu Ser Val Gln 
            340                 345                 350         


Tyr Pro Pro Glu Asn Leu Arg Val Met Val Ser Gln Ala Asn Arg Thr 
        355                 360                 365             


Val Leu Glu Asn Leu Gly Asn Gly Thr Ser Leu Pro Val Leu Glu Gly 
    370                 375                 380                 


Gln Ser Leu Arg Leu Val Cys Val Thr His Ser Ser Pro Pro Ala Arg 
385                 390                 395                 400 


Leu Ser Trp Thr Arg Trp Gly Gln Thr Val Gly Pro Ser Gln Pro Ser 
                405                 410                 415     


Asp Pro Gly Val Leu Glu Leu Pro Pro Ile Gln Met Glu His Glu Gly 
            420                 425                 430         


Glu Phe Thr Cys His Ala Gln His Pro Leu Gly Ser Gln His Val Ser 
        435                 440                 445             


Leu Ser Leu Ser Val His Trp Lys Leu Glu His Gly Gly Gly Leu Gly 
    450                 455                 460                 


Leu Gly Ala Ala Leu Gly Ala Gly Val Ala Ala Leu Leu Ala Phe Cys 
465                 470                 475                 480 


Ser Cys Leu Val Val Phe Arg Val Lys Ile Cys Arg Lys Glu Ala Arg 
                485                 490                 495     


Lys Arg Ala Ala Ala Glu Gln Asp Val Pro Ser Thr Leu Gly Pro Ile 
            500                 505                 510         


Ser Gln Gly His Gln His Glu Cys Ser Ala Gly Ser Ser Gln Asp His 
        515                 520                 525             


Pro Pro Pro Gly Ala Ala Thr Tyr Thr Pro Gly Lys Gly Glu Glu Gln 
    530                 535                 540                 


Glu Leu His Tyr Ala Ser Leu Ser Phe Gln Gly Leu Arg Leu Trp Glu 
545                 550                 555                 560 


Pro Ala Asp Gln Glu Ala Pro Ser Thr Thr Glu Tyr Ser Glu Ile Lys 
                565                 570                 575     


Ile His Thr Gly Gln Pro Leu Arg Gly Pro Gly Phe Gly Leu Gln Leu 
            580                 585                 590         


Glu Arg Glu Met Ser Gly Met Val Pro Lys 
        595                 600         


<210>  1534
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  1534

Met Met Leu Ile Pro Thr His His Phe Arg Asn Ile Glu Arg Lys Pro 
1               5                   10                  15      


Glu Tyr Leu Gln Pro Glu Lys Cys Val Pro Pro Pro Tyr Pro Gly Pro 
            20                  25                  30          


Val Gly Thr Met Trp Phe Ile Arg Asp Gly Cys Gly Ile Ala Cys Ala 
        35                  40                  45              


Ile Val Thr Trp Phe Leu Val Leu Tyr Ala Glu Phe Val Val Leu Phe 
    50                  55                  60                  


Val Met Leu Ile Pro Ser Arg Asp Tyr Val Tyr Ser Ile Ile Asn Gly 
65                  70                  75                  80  


Ile Val Phe Asn Leu Leu Ala Phe Leu Ala Leu Ala Ser His Cys Arg 
                85                  90                  95      


Ala Met Leu Thr Asp Pro Gly Ala Val Pro Lys Gly Asn Ala Thr Lys 
            100                 105                 110         


Glu Phe Ile Glu Ser Leu Gln Leu Lys Pro Gly Gln Val Val Tyr Lys 
        115                 120                 125             


Cys Pro Lys Cys Cys Ser Ile Lys Pro Asp Arg Ala His His Cys Ser 
    130                 135                 140                 


Val Cys Lys Arg Cys Ile Arg Lys Met Asp His His Cys Pro Trp Val 
145                 150                 155                 160 


Asn Asn Cys Val Gly Glu Asn Asn Gln Lys Tyr Phe Val Leu Phe Thr 
                165                 170                 175     


Met Tyr Ile Ala Leu Ile Ser Leu His Ala Leu Ile Met Val Gly Phe 
            180                 185                 190         


His Phe Leu His Cys Phe Glu Glu Asp Trp Thr Lys Cys Ser Ser Phe 
        195                 200                 205             


Ser Pro Pro Thr Thr Val Ile Leu Leu Ile Leu Leu Cys Phe Glu Gly 
    210                 215                 220                 


Leu Leu Phe Leu Ile Phe Thr Ser Val Met Phe Gly Thr Gln Val His 
225                 230                 235                 240 


Ser Ile Cys Thr Asp Glu Thr Gly Ile Glu Gln Leu Lys Lys Glu Glu 
                245                 250                 255     


Arg Arg Trp Ala Lys Lys Thr Lys Trp Met Asn Met Lys Ala Val Phe 
            260                 265                 270         


Gly His Pro Phe Ser Leu Gly Trp Ala Ser Pro Phe Ala Thr Pro Asp 
        275                 280                 285             


Gln Gly Lys Ala Asp Pro Tyr Gln Tyr Val Val 
    290                 295                 


<210>  1535
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  1535

Met Met Leu Ile Pro Thr His His Phe Arg Asn Ile Glu Arg Lys Pro 
1               5                   10                  15      


Glu Tyr Leu Gln Pro Glu Lys Cys Val Pro Pro Pro Tyr Pro Gly Pro 
            20                  25                  30          


Val Gly Thr Met Trp Phe Ile Arg Asp Gly Cys Gly Ile Ala Cys Ala 
        35                  40                  45              


Ile Val Thr Trp Phe Leu Val Leu Tyr Ala Glu Phe Val Val Leu Phe 
    50                  55                  60                  


Val Met Leu Ile Pro Ser Arg Asp Tyr Val Tyr Ser Ile Ile Asn Gly 
65                  70                  75                  80  


Ile Val Phe Asn Leu Leu Ala Phe Leu Ala Leu Ala Ser His Cys Arg 
                85                  90                  95      


Ala Met Leu Thr Asp Pro Gly Ala Val Pro Lys Gly Asn Ala Thr Lys 
            100                 105                 110         


Glu Phe Ile Glu Ser Leu Gln Leu Lys Pro Gly Gln Val Val Tyr Lys 
        115                 120                 125             


Cys Pro Lys Cys Cys Ser Ile Lys Pro Asp Arg Ala His His Cys Ser 
    130                 135                 140                 


Val Cys Lys Arg Cys Ile Arg Lys Met Asp His His Cys Pro Trp Val 
145                 150                 155                 160 


Asn Asn Cys Val Gly Glu Asn Asn Gln Lys Tyr Phe Val Leu Phe Thr 
                165                 170                 175     


Met Tyr Ile Ala Leu Ile Ser Leu His Ala Leu Ile Met Val Gly Phe 
            180                 185                 190         


His Phe Leu His Cys Phe Glu Glu Asp Trp Thr Lys Cys Ser Ser Phe 
        195                 200                 205             


Ser Pro Pro Thr Thr Val Ile Leu Leu Ile Leu Leu Cys Phe Glu Gly 
    210                 215                 220                 


Leu Leu Phe Leu Ile Phe Thr Ser Val Met Phe Gly Thr Gln Val His 
225                 230                 235                 240 


Ser Ile Cys Thr Asp Glu Thr Gly Ile Glu Gln Leu Lys Lys Glu Glu 
                245                 250                 255     


Arg Arg Trp Ala Lys Lys Thr Lys Trp Met Asn Met Lys Ala Val Phe 
            260                 265                 270         


Gly His Pro Phe Ser Leu Gly Trp Ala Ser Pro Phe Ala Thr Pro Asp 
        275                 280                 285             


Gln Gly Lys Ala Asp Pro Tyr Gln Tyr Val Val 
    290                 295                 


<210>  1536
<211>  706
<212>  PRT
<213>  Homo sapiens

<400>  1536

Met Ser Lys Glu Leu Ala Ala Met Gly Pro Gly Ala Ser Gly Asp Gly 
1               5                   10                  15      


Val Arg Thr Glu Thr Ala Pro His Ile Ala Leu Asp Ser Arg Val Gly 
            20                  25                  30          


Leu His Ala Tyr Asp Ile Ser Val Val Val Ile Tyr Phe Val Phe Val 
        35                  40                  45              


Ile Ala Val Gly Ile Trp Ser Ser Ile Arg Ala Ser Arg Gly Thr Ile 
    50                  55                  60                  


Gly Gly Tyr Phe Leu Ala Gly Arg Ser Met Ser Trp Trp Pro Ile Gly 
65                  70                  75                  80  


Ala Ser Leu Met Ser Ser Asn Val Gly Ser Gly Leu Phe Ile Gly Leu 
                85                  90                  95      


Ala Gly Thr Gly Ala Ala Gly Gly Leu Ala Val Gly Gly Phe Glu Trp 
            100                 105                 110         


Asn Met Arg Lys Ser Arg Ser Gly Gly Asp Arg Gly Ile His Pro Arg 
        115                 120                 125             


Ser His Gly Arg Thr Gly Val Arg Ser Gln Ala Thr Trp Leu Leu Leu 
    130                 135                 140                 


Ala Leu Gly Trp Val Phe Val Pro Val Tyr Ile Ala Ala Gly Val Val 
145                 150                 155                 160 


Thr Met Pro Gln Tyr Leu Lys Lys Arg Phe Gly Gly Gln Arg Ile Gln 
                165                 170                 175     


Val Tyr Met Ser Val Leu Ser Leu Ile Leu Tyr Ile Phe Thr Lys Ile 
            180                 185                 190         


Ser Thr Asp Ile Phe Ser Gly Ala Leu Phe Ile Gln Met Ala Leu Gly 
        195                 200                 205             


Trp Asn Leu Tyr Leu Ser Thr Gly Ile Leu Leu Val Val Thr Ala Val 
    210                 215                 220                 


Tyr Thr Ile Ala Gly Gly Leu Met Ala Val Ile Tyr Thr Asp Ala Leu 
225                 230                 235                 240 


Gln Thr Val Ile Met Val Gly Gly Ala Leu Val Leu Met Phe Leu Gly 
                245                 250                 255     


Phe Gln Asp Val Gly Trp Tyr Pro Gly Leu Glu Gln Arg Tyr Arg Gln 
            260                 265                 270         


Ala Ile Pro Asn Val Thr Val Pro Asn Thr Thr Cys His Leu Pro Arg 
        275                 280                 285             


Pro Asp Ala Phe His Ile Leu Arg Asp Pro Val Ser Gly Asp Ile Pro 
    290                 295                 300                 


Trp Pro Gly Leu Ile Phe Gly Leu Thr Val Leu Ala Thr Trp Cys Trp 
305                 310                 315                 320 


Cys Thr Asp Gln Val Ile Val Gln Arg Ser Leu Ser Ala Lys Ser Leu 
                325                 330                 335     


Ser His Ala Lys Gly Gly Ser Val Leu Gly Gly Tyr Leu Lys Ile Leu 
            340                 345                 350         


Pro Met Phe Phe Ile Val Met Pro Gly Met Ile Ser Arg Ala Leu Phe 
        355                 360                 365             


Pro Asp Glu Val Gly Cys Val Asp Pro Asp Val Cys Gln Arg Ile Cys 
    370                 375                 380                 


Gly Ala Arg Val Gly Cys Ser Asn Ile Ala Tyr Pro Lys Leu Val Met 
385                 390                 395                 400 


Ala Leu Met Pro Val Gly Leu Arg Gly Leu Met Ile Ala Val Ile Met 
                405                 410                 415     


Ala Ala Leu Met Ser Ser Leu Thr Ser Ile Phe Asn Ser Ser Ser Thr 
            420                 425                 430         


Leu Phe Thr Ile Asp Val Trp Gln Arg Phe Arg Arg Lys Ser Thr Glu 
        435                 440                 445             


Gln Glu Leu Met Val Val Gly Arg Val Phe Val Val Phe Leu Val Val 
    450                 455                 460                 


Ile Ser Ile Leu Trp Ile Pro Ile Ile Gln Ser Ser Asn Ser Gly Gln 
465                 470                 475                 480 


Leu Phe Asp Tyr Ile Gln Ala Val Thr Ser Tyr Leu Ala Pro Pro Ile 
                485                 490                 495     


Thr Ala Leu Phe Leu Leu Ala Ile Phe Cys Lys Arg Val Thr Glu Pro 
            500                 505                 510         


Gly Ala Phe Trp Gly Leu Val Phe Gly Leu Gly Val Gly Leu Leu Arg 
        515                 520                 525             


Met Ile Leu Glu Phe Ser Tyr Pro Ala Pro Ala Cys Gly Glu Val Asp 
    530                 535                 540                 


Arg Arg Pro Ala Val Leu Lys Asp Phe His Tyr Leu Tyr Phe Ala Ile 
545                 550                 555                 560 


Leu Leu Cys Gly Leu Thr Ala Ile Val Ile Val Ile Val Ser Leu Cys 
                565                 570                 575     


Thr Thr Pro Ile Pro Glu Glu Gln Leu Thr Arg Leu Thr Trp Trp Thr 
            580                 585                 590         


Arg Asn Cys Pro Leu Ser Glu Leu Glu Lys Glu Ala His Glu Ser Thr 
        595                 600                 605             


Pro Glu Ile Ser Glu Arg Pro Ala Gly Glu Cys Pro Ala Gly Gly Gly 
    610                 615                 620                 


Ala Ala Glu Asn Ser Ser Leu Gly Gln Glu Gln Pro Glu Ala Pro Ser 
625                 630                 635                 640 


Arg Ser Trp Gly Lys Leu Leu Trp Ser Trp Phe Cys Gly Leu Ser Gly 
                645                 650                 655     


Thr Pro Glu Gln Ala Leu Ser Pro Ala Glu Lys Ala Ala Leu Glu Gln 
            660                 665                 670         


Lys Leu Thr Ser Ile Glu Glu Glu Pro Leu Trp Arg His Val Cys Asn 
        675                 680                 685             


Ile Asn Ala Val Leu Leu Leu Ala Ile Asn Ile Phe Leu Trp Gly Tyr 
    690                 695                 700                 


Phe Ala 
705     


<210>  1537
<211>  540
<212>  PRT
<213>  Homo sapiens

<400>  1537

Met Met Gly Ser Pro Val Ser His Leu Leu Ala Gly Phe Cys Val Trp 
1               5                   10                  15      


Val Val Leu Gly Trp Val Gly Gly Ser Val Pro Asn Leu Gly Pro Ala 
            20                  25                  30          


Glu Gln Glu Gln Asn His Tyr Leu Ala Gln Leu Phe Gly Leu Tyr Gly 
        35                  40                  45              


Glu Asn Gly Thr Leu Thr Ala Gly Gly Leu Ala Arg Leu Leu His Ser 
    50                  55                  60                  


Leu Gly Leu Gly Arg Val Gln Gly Leu Arg Leu Gly Gln His Gly Pro 
65                  70                  75                  80  


Leu Thr Gly Arg Ala Ala Ser Pro Ala Ala Asp Asn Ser Thr His Arg 
                85                  90                  95      


Pro Gln Asn Pro Glu Leu Ser Val Asp Val Trp Ala Gly Met Pro Leu 
            100                 105                 110         


Gly Pro Ser Gly Trp Gly Asp Leu Glu Glu Ser Lys Ala Pro His Leu 
        115                 120                 125             


Pro Arg Gly Pro Ala Pro Ser Gly Leu Asp Leu Leu His Arg Leu Leu 
    130                 135                 140                 


Leu Leu Asp His Ser Leu Ala Asp His Leu Asn Glu Asp Cys Leu Asn 
145                 150                 155                 160 


Gly Ser Gln Leu Leu Val Asn Phe Gly Leu Ser Pro Ala Ala Pro Leu 
                165                 170                 175     


Thr Pro Arg Gln Phe Ala Leu Leu Cys Pro Ala Leu Leu Tyr Gln Ile 
            180                 185                 190         


Asp Ser Arg Val Cys Ile Gly Ala Pro Ala Pro Ala Pro Pro Gly Asp 
        195                 200                 205             


Leu Leu Ser Ala Leu Leu Gln Ser Ala Leu Ala Val Leu Leu Leu Ser 
    210                 215                 220                 


Leu Pro Ser Pro Leu Ser Leu Leu Leu Leu Arg Leu Leu Gly Pro Arg 
225                 230                 235                 240 


Leu Leu Arg Pro Leu Leu Gly Phe Leu Gly Ala Leu Ala Val Gly Thr 
                245                 250                 255     


Leu Cys Gly Asp Ala Leu Leu His Leu Leu Pro His Ala Gln Glu Gly 
            260                 265                 270         


Arg His Ala Gly Pro Gly Gly Leu Pro Glu Lys Asp Leu Gly Pro Gly 
        275                 280                 285             


Leu Ser Val Leu Gly Gly Leu Phe Leu Leu Phe Val Leu Glu Asn Met 
    290                 295                 300                 


Leu Gly Leu Leu Arg His Arg Gly Leu Arg Pro Arg Cys Cys Arg Arg 
305                 310                 315                 320 


Lys Arg Arg Asn Leu Glu Thr Arg Asn Leu Asp Pro Glu Asn Gly Ser 
                325                 330                 335     


Gly Met Ala Leu Gln Pro Leu Gln Ala Ala Pro Glu Pro Gly Ala Gln 
            340                 345                 350         


Gly Gln Arg Glu Lys Asn Ser Gln His Pro Pro Ala Leu Ala Pro Pro 
        355                 360                 365             


Gly His Gln Gly His Ser His Gly His Gln Gly Gly Thr Asp Ile Thr 
    370                 375                 380                 


Trp Met Val Leu Leu Gly Asp Gly Leu His Asn Leu Thr Asp Gly Leu 
385                 390                 395                 400 


Ala Ile Gly Ala Ala Phe Ser Asp Gly Phe Ser Ser Gly Leu Ser Thr 
                405                 410                 415     


Thr Leu Ala Val Phe Cys His Glu Leu Pro His Glu Leu Gly Asp Phe 
            420                 425                 430         


Ala Met Leu Leu Gln Ser Gly Leu Ser Phe Arg Arg Leu Leu Leu Leu 
        435                 440                 445             


Ser Leu Val Ser Gly Ala Leu Gly Leu Gly Gly Ala Val Leu Gly Val 
    450                 455                 460                 


Gly Leu Ser Leu Gly Pro Val Pro Leu Thr Pro Trp Val Phe Gly Val 
465                 470                 475                 480 


Thr Ala Gly Val Phe Leu Tyr Val Ala Leu Val Asp Met Leu Pro Ala 
                485                 490                 495     


Leu Leu Arg Pro Pro Glu Pro Leu Pro Thr Pro His Val Leu Leu Gln 
            500                 505                 510         


Gly Leu Gly Leu Leu Leu Gly Gly Gly Leu Met Leu Ala Ile Thr Leu 
        515                 520                 525             


Leu Glu Glu Arg Leu Leu Pro Val Thr Thr Glu Gly 
    530                 535                 540 


<210>  1538
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  1538

Met Pro Lys Thr Met His Phe Leu Phe Arg Phe Ile Val Phe Phe Tyr 
1               5                   10                  15      


Leu Trp Gly Leu Phe Thr Ala Gln Arg Gln Lys Lys Glu Glu Ser Thr 
            20                  25                  30          


Glu Glu Val Lys Ile Glu Val Leu His Arg Pro Glu Asn Cys Ser Lys 
        35                  40                  45              


Thr Ser Lys Lys Gly Asp Leu Leu Asn Ala His Tyr Asp Gly Tyr Leu 
    50                  55                  60                  


Ala Lys Asp Gly Ser Lys Phe Tyr Cys Ser Arg Thr Gln Asn Glu Gly 
65                  70                  75                  80  


His Pro Lys Trp Phe Val Leu Gly Val Gly Gln Val Ile Lys Gly Leu 
                85                  90                  95      


Asp Ile Ala Met Thr Asp Met Cys Pro Gly Glu Lys Arg Lys Val Val 
            100                 105                 110         


Ile Pro Pro Ser Phe Ala Tyr Gly Lys Glu Gly Tyr Glu Gly Lys Ile 
        115                 120                 125             


Pro Pro Asp Ala Thr Leu Ile Phe Glu Ile Glu Leu Tyr Ala Val Thr 
    130                 135                 140                 


Lys Gly Pro Arg Ser Ile Glu Thr Phe Lys Gln Ile Asp Met Asp Asn 
145                 150                 155                 160 


Asp Arg Gln Leu Ser Lys Ala Glu Ile Asn Leu Tyr Leu Gln Arg Glu 
                165                 170                 175     


Phe Glu Lys Asp Glu Lys Pro Arg Asp Lys Ser Tyr Gln Asp Ala Val 
            180                 185                 190         


Leu Glu Asp Ile Phe Lys Lys Asn Asp His Asp Gly Asp Gly Phe Ile 
        195                 200                 205             


Ser Pro Lys Glu Tyr Asn Val Tyr Gln His Asp Glu Leu 
    210                 215                 220     


<210>  1539
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  1539

Met Ser Arg Glu Met Gln Asp Val Asp Leu Ala Glu Val Lys Pro Leu 
1               5                   10                  15      


Val Glu Lys Gly Glu Thr Ile Thr Gly Leu Leu Gln Glu Phe Asp Val 
            20                  25                  30          


Gln Glu Gln Asp Ile Glu Thr Leu His Gly Ser Val His Val Thr Leu 
        35                  40                  45              


Cys Gly Thr Pro Lys Gly Asn Arg Pro Val Ile Leu Thr Tyr His Asp 
    50                  55                  60                  


Ile Gly Met Asn His Lys Thr Cys Tyr Asn Pro Leu Phe Asn Tyr Glu 
65                  70                  75                  80  


Asp Met Gln Glu Ile Thr Gln His Phe Ala Val Cys His Val Asp Ala 
                85                  90                  95      


Pro Gly Gln Gln Asp Gly Ala Ala Ser Phe Pro Ala Gly Tyr Met Tyr 
            100                 105                 110         


Pro Ser Met Asp Gln Leu Ala Glu Met Leu Pro Gly Val Leu Gln Gln 
        115                 120                 125             


Phe Gly Leu Lys Ser Ile Ile Gly Met Gly Thr Gly Ala Gly Ala Tyr 
    130                 135                 140                 


Ile Leu Thr Arg Phe Ala Leu Asn Asn Pro Glu Met Val Glu Gly Leu 
145                 150                 155                 160 


Val Leu Ile Asn Val Asn Pro Cys Ala Glu Gly Trp Met Asp Trp Ala 
                165                 170                 175     


Ala Ser Lys Ile Ser Gly Trp Thr Gln Ala Leu Pro Asp Met Val Val 
            180                 185                 190         


Ser His Leu Phe Gly Lys Glu Glu Met Gln Ser Asn Val Glu Val Val 
        195                 200                 205             


His Thr Tyr Arg Gln His Ile Val Asn Asp Met Asn Pro Gly Asn Leu 
    210                 215                 220                 


His Leu Phe Ile Asn Ala Tyr Asn Ser Arg Arg Asp Leu Glu Ile Glu 
225                 230                 235                 240 


Arg Pro Met Pro Gly Thr His Thr Val Thr Leu Gln Cys Pro Ala Leu 
                245                 250                 255     


Leu Val Val Gly Asp Ser Ser Pro Ala Val Asp Ala Val Val Glu Cys 
            260                 265                 270         


Asn Ser Lys Leu Asp Pro Thr Lys Thr Thr Leu Leu Lys Met Ala Asp 
        275                 280                 285             


Cys Gly Gly Leu Pro Gln Ile Ser Gln Pro Ala Lys Leu Ala Glu Ala 
    290                 295                 300                 


Phe Lys Tyr Phe Val Gln Gly Met Gly Tyr Met Pro Ser Ala Ser Met 
305                 310                 315                 320 


Thr Arg Leu Met Arg Ser Arg Thr Ala Ser Gly Ser Ser Val Thr Ser 
                325                 330                 335     


Leu Asp Gly Thr Arg Ser Arg Ser His Thr Ser Glu Gly Thr Arg Ser 
            340                 345                 350         


Arg Ser His Thr Ser Glu Gly Thr Arg Ser Arg Ser His Thr Ser Glu 
        355                 360                 365             


Gly Ala His Leu Asp Ile Thr Pro Asn Ser Gly Ala Ala Gly Asn Ser 
    370                 375                 380                 


Ala Gly Pro Lys Ser Met Glu Val Ser Cys 
385                 390                 


<210>  1540
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  1540

Met Pro Ala Gly Val Pro Met Ser Thr Tyr Leu Lys Met Phe Ala Ala 
1               5                   10                  15      


Ser Leu Leu Ala Met Cys Ala Gly Ala Glu Val Val His Arg Tyr Tyr 
            20                  25                  30          


Arg Pro Asp Leu Thr Ile Pro Glu Ile Pro Pro Lys Arg Gly Glu Leu 
        35                  40                  45              


Lys Thr Glu Leu Leu Gly Leu Lys Glu Arg Lys His Lys Pro Gln Val 
    50                  55                  60                  


Ser Gln Gln Glu Glu Leu Lys 
65                  70      


<210>  1541
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  1541

Met Asn Ile Leu Gly Leu Val Leu Phe Ala Leu Val Leu Gly Val Ala 
1               5                   10                  15      


Leu Lys Lys Leu Gly Ser Glu Gly Glu Asp Leu Ile Arg Phe Phe Asn 
            20                  25                  30          


Ser Leu Asn Glu Ala Thr Met Val Leu Val Ser Trp Ile Met Cys Ser 
        35                  40                  45              


Ala Thr Leu Pro Ser Met Met Lys Cys Ile Glu Glu Asn Asn Gly Val 
    50                  55                  60                  


Asp Lys Arg Ile Ser Arg Phe Ile Leu Pro Ile Gly Ala Thr Val Asn 
65                  70                  75                  80  


Met Asp Gly Ala Ala Ile Phe Gln Cys Val Ala Ala Val Phe Ile Ala 
                85                  90                  95      


Gln Leu Asn Asn Val Glu Leu Asn Ala Gly Gln Ile Phe Thr Ile Leu 
            100                 105                 110         


Val Thr Ala Thr Ala Ser Ser Val Gly Ala Ala Gly Val Pro Ala Gly 
        115                 120                 125             


Gly Val Leu Thr Ile Ala Ile Ile Leu Glu Ala Ile Gly Leu Pro Thr 
    130                 135                 140                 


His Asp Leu Pro Leu Ile Leu Ala Val Asp Trp Ile Val Asp Arg Thr 
145                 150                 155                 160 


Thr Thr Val Val Asn Val Glu Gly Asp Ala Leu Gly Ala Gly Ile Leu 
                165                 170                 175     


His His Leu Asn Gln Lys Ala Thr Lys Lys Gly Glu Gln Glu Leu Ala 
            180                 185                 190         


Glu Val Lys Val Glu Ala Ile Pro Asn Cys Lys Ser Glu Glu Glu Thr 
        195                 200                 205             


Ser Pro Leu Val Thr His Gln Asn Pro Ala Gly Pro Val Ala Ser Ala 
    210                 215                 220                 


Pro Glu Leu Glu Ser Lys Glu Ser Val Leu 
225                 230                 


<210>  1542
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  1542

Met Glu Gln Gln Asp Gln Ser Met Lys Glu Gly Arg Leu Thr Leu Val 
1               5                   10                  15      


Leu Ala Leu Ala Thr Leu Ile Ala Ala Phe Gly Ser Ser Phe Gln Tyr 
            20                  25                  30          


Gly Tyr Asn Val Ala Ala Val Asn Ser Pro Ala Leu Leu Met Gln Gln 
        35                  40                  45              


Phe Tyr Asn Glu Thr Tyr Tyr Gly Arg Thr Gly Glu Phe Met Glu Asp 
    50                  55                  60                  


Phe Pro Leu Thr Leu Leu Trp Ser Val Thr Val Ser Met Phe Pro Phe 
65                  70                  75                  80  


Gly Gly Phe Ile Gly Ser Leu Leu Val Gly Pro Leu Val Asn Lys Phe 
                85                  90                  95      


Gly Arg Lys Gly Ala Leu Leu Phe Asn Asn Ile Phe Ser Ile Val Pro 
            100                 105                 110         


Ala Ile Leu Met Gly Cys Ser Arg Val Ala Thr Ser Phe Glu Leu Ile 
        115                 120                 125             


Ile Ile Ser Arg Leu Leu Val Gly Ile Cys Ala Gly Val Ser Ser Asn 
    130                 135                 140                 


Val Val Pro Met Tyr Leu Gly Glu Leu Ala Pro Lys Asn Leu Arg Gly 
145                 150                 155                 160 


Ala Leu Gly Val Val Pro Gln Leu Phe Ile Thr Val Gly Ile Leu Val 
                165                 170                 175     


Ala Gln Ile Phe Gly Leu Arg Asn Leu Leu Ala Asn Val Asp Gly Glu 
            180                 185                 190         


Phe Arg Thr Ser Arg Glu His Pro His Pro Phe Thr Thr Thr Leu Gly 
        195                 200                 205             


Pro Leu Leu Val Phe Gln Ser His His His Arg Thr Gly Leu Ser Ala 
    210                 215                 220                 


Asp Trp Ser Leu Leu Thr Gly Trp Met Ser Leu Gly Gly Pro Ser Cys 
225                 230                 235                 240 


Pro Glu Pro Thr 
                


<210>  1543
<211>  1446
<212>  PRT
<213>  Homo sapiens

<400>  1543

Met Asp Thr Thr Ala Ala Ala Ala Leu Pro Ala Phe Val Ala Leu Leu 
1               5                   10                  15      


Leu Leu Ser Pro Trp Pro Leu Leu Gly Ser Ala Gln Gly Gln Phe Ser 
            20                  25                  30          


Ala Gly Gly Cys Thr Phe Asp Asp Gly Pro Gly Ala Cys Asp Tyr His 
        35                  40                  45              


Gln Asp Leu Tyr Asp Asp Phe Glu Trp Val His Val Ser Ala Gln Glu 
    50                  55                  60                  


Pro His Tyr Leu Pro Pro Glu Met Pro Gln Gly Ser Tyr Met Ile Val 
65                  70                  75                  80  


Asp Ser Ser Asp His Asp Pro Gly Glu Lys Ala Arg Leu Gln Leu Pro 
                85                  90                  95      


Thr Met Lys Glu Asn Asp Thr His Cys Ile Asp Phe Ser Tyr Leu Leu 
            100                 105                 110         


Tyr Ser Gln Lys Gly Leu Asn Pro Gly Thr Leu Asn Ile Leu Val Arg 
        115                 120                 125             


Val Asn Lys Gly Pro Leu Ala Asn Pro Ile Trp Asn Val Thr Gly Phe 
    130                 135                 140                 


Thr Gly Arg Asp Trp Leu Arg Ala Glu Leu Ala Val Ser Thr Phe Trp 
145                 150                 155                 160 


Pro Asn Glu Tyr Gln Val Ile Phe Glu Ala Glu Val Ser Gly Gly Arg 
                165                 170                 175     


Ser Gly Tyr Ile Ala Ile Asp Asp Ile Gln Val Leu Ser Tyr Pro Cys 
            180                 185                 190         


Asp Lys Ser Pro His Phe Leu Arg Leu Gly Asp Val Glu Val Asn Ala 
        195                 200                 205             


Gly Gln Asn Ala Thr Phe Gln Cys Ile Ala Thr Gly Arg Asp Ala Val 
    210                 215                 220                 


His Asn Lys Leu Trp Leu Gln Arg Arg Asn Gly Glu Asp Ile Pro Val 
225                 230                 235                 240 


Ala Gln Thr Lys Asn Ile Asn His Arg Arg Phe Ala Ala Ser Phe Arg 
                245                 250                 255     


Leu Gln Glu Val Thr Lys Thr Asp Gln Asp Leu Tyr Arg Cys Val Thr 
            260                 265                 270         


Gln Ser Glu Arg Gly Ser Gly Val Ser Asn Phe Ala Gln Leu Ile Val 
        275                 280                 285             


Arg Glu Pro Pro Arg Pro Ile Ala Pro Pro Gln Leu Leu Gly Val Gly 
    290                 295                 300                 


Pro Thr Tyr Leu Leu Ile Gln Leu Asn Ala Asn Ser Ile Ile Gly Asp 
305                 310                 315                 320 


Gly Pro Ile Ile Leu Lys Glu Val Glu Tyr Arg Met Thr Ser Gly Ser 
                325                 330                 335     


Trp Thr Glu Thr His Ala Val Asn Ala Pro Thr Tyr Lys Leu Trp His 
            340                 345                 350         


Leu Asp Pro Asp Thr Glu Tyr Glu Ile Arg Val Leu Leu Thr Arg Pro 
        355                 360                 365             


Gly Glu Gly Gly Thr Gly Leu Pro Gly Pro Pro Leu Ile Thr Arg Thr 
    370                 375                 380                 


Lys Cys Ala Glu Pro Met Arg Thr Pro Lys Thr Leu Lys Ile Ala Glu 
385                 390                 395                 400 


Ile Gln Ala Arg Arg Ile Ala Val Asp Trp Glu Ser Leu Gly Tyr Asn 
                405                 410                 415     


Ile Thr Arg Cys His Thr Phe Asn Val Thr Ile Cys Tyr His Tyr Phe 
            420                 425                 430         


Arg Gly His Asn Glu Ser Lys Ala Asp Cys Leu Asp Met Asp Pro Lys 
        435                 440                 445             


Ala Pro Gln His Val Val Asn His Leu Pro Pro Tyr Thr Asn Val Ser 
    450                 455                 460                 


Leu Lys Met Ile Leu Thr Asn Pro Glu Gly Arg Lys Glu Ser Glu Glu 
465                 470                 475                 480 


Thr Ile Ile Gln Thr Asp Glu Asp Val Pro Gly Pro Val Pro Val Lys 
                485                 490                 495     


Ser Leu Gln Gly Thr Ser Phe Glu Asn Lys Ile Phe Leu Asn Trp Lys 
            500                 505                 510         


Glu Pro Leu Asp Pro Asn Gly Ile Ile Thr Gln Tyr Glu Ile Ser Tyr 
        515                 520                 525             


Ser Ser Ile Arg Ser Phe Asp Pro Ala Val Pro Val Ala Gly Pro Pro 
    530                 535                 540                 


Gln Thr Val Ser Asn Leu Trp Asn Ser Thr His His Val Phe Met His 
545                 550                 555                 560 


Leu His Pro Gly Thr Thr Tyr Gln Phe Phe Ile Arg Ala Ser Thr Val 
                565                 570                 575     


Lys Gly Phe Gly Pro Ala Thr Ala Ile Asn Val Thr Thr Asn Ile Ser 
            580                 585                 590         


Ala Pro Thr Leu Pro Asp Tyr Glu Gly Val Asp Ala Ser Leu Asn Glu 
        595                 600                 605             


Thr Ala Thr Thr Ile Thr Val Leu Leu Arg Pro Ala Gln Ala Lys Gly 
    610                 615                 620                 


Ala Pro Ile Ser Ala Tyr Gln Ile Val Val Glu Glu Leu His Pro His 
625                 630                 635                 640 


Arg Thr Lys Arg Glu Ala Gly Ala Met Glu Cys Tyr Gln Val Pro Val 
                645                 650                 655     


Thr Tyr Gln Asn Ala Met Ser Gly Gly Ala Pro Tyr Tyr Phe Ala Ala 
            660                 665                 670         


Glu Leu Pro Pro Gly Asn Leu Pro Glu Pro Ala Pro Phe Thr Val Gly 
        675                 680                 685             


Asp Asn Arg Thr Tyr Gln Gly Phe Trp Asn Pro Pro Leu Ala Pro Arg 
    690                 695                 700                 


Lys Gly Tyr Asn Ile Tyr Phe Gln Ala Met Ser Ser Val Glu Lys Glu 
705                 710                 715                 720 


Thr Lys Thr Gln Cys Val Arg Ile Ala Thr Lys Ala Ala Ala Thr Glu 
                725                 730                 735     


Glu Pro Glu Val Ile Pro Asp Pro Ala Lys Gln Thr Asp Arg Val Val 
            740                 745                 750         


Lys Ile Ala Gly Ile Ser Ala Gly Ile Leu Val Phe Ile Leu Leu Leu 
        755                 760                 765             


Leu Val Val Ile Leu Ile Val Lys Lys Ser Lys Leu Ala Lys Lys Arg 
    770                 775                 780                 


Lys Asp Ala Met Gly Asn Thr Arg Gln Glu Met Thr His Met Val Asn 
785                 790                 795                 800 


Ala Met Asp Arg Ser Tyr Ala Asp Gln Ser Thr Leu His Ala Glu Asp 
                805                 810                 815     


Pro Leu Ser Ile Thr Phe Met Asp Gln His Asn Phe Ser Pro Arg Tyr 
            820                 825                 830         


Glu Asn His Ser Ala Thr Ala Glu Ser Ser Arg Leu Leu Asp Val Pro 
        835                 840                 845             


Arg Tyr Leu Cys Glu Gly Thr Glu Ser Pro Tyr Gln Thr Gly Gln Leu 
    850                 855                 860                 


His Pro Ala Ile Arg Val Ala Asp Leu Leu Gln His Ile Asn Leu Met 
865                 870                 875                 880 


Lys Thr Ser Asp Ser Tyr Gly Phe Lys Glu Glu Tyr Glu Ser Phe Phe 
                885                 890                 895     


Glu Gly Gln Ser Ala Ser Trp Asp Val Ala Lys Lys Asp Gln Asn Arg 
            900                 905                 910         


Ala Lys Asn Arg Tyr Gly Asn Ile Ile Ala Tyr Asp His Ser Arg Val 
        915                 920                 925             


Ile Leu Gln Pro Val Glu Asp Asp Pro Ser Ser Asp Tyr Ile Asn Ala 
    930                 935                 940                 


Asn Tyr Ile Asp Ile Trp Leu Tyr Arg Asp Gly Tyr Gln Arg Pro Ser 
945                 950                 955                 960 


His Tyr Ile Ala Thr Gln Gly Pro Val His Glu Thr Val Tyr Asp Phe 
                965                 970                 975     


Trp Arg Met Ile Trp Gln Glu Gln Ser Ala Cys Ile Val Met Val Thr 
            980                 985                 990         


Asn Leu Val Glu Val Gly Arg Val  Lys Cys Tyr Lys Tyr  Trp Pro Asp 
        995                 1000                 1005             


Asp Thr  Glu Val Tyr Gly Asp  Phe Lys Val Thr Cys  Val Glu Met 
    1010                 1015                 1020             


Glu Pro  Leu Ala Glu Tyr Val  Val Arg Thr Phe Thr  Leu Glu Arg 
    1025                 1030                 1035             


Arg Gly  Tyr Asn Glu Ile Arg  Glu Val Lys Gln Phe  His Phe Thr 
    1040                 1045                 1050             


Gly Trp  Pro Asp His Gly Val  Pro Tyr His Ala Thr  Gly Leu Leu 
    1055                 1060                 1065             


Ser Phe  Ile Arg Arg Val Lys  Leu Ser Asn Pro Pro  Ser Ala Gly 
    1070                 1075                 1080             


Pro Ile  Val Val His Cys Ser  Ala Gly Ala Gly Arg  Thr Gly Cys 
    1085                 1090                 1095             


Tyr Ile  Val Ile Asp Ile Met  Leu Asp Met Ala Glu  Arg Glu Gly 
    1100                 1105                 1110             


Val Val  Asp Ile Tyr Asn Cys  Val Lys Ala Leu Arg  Ser Arg Arg 
    1115                 1120                 1125             


Ile Asn  Met Val Gln Thr Glu  Glu Gln Tyr Ile Phe  Ile His Asp 
    1130                 1135                 1140             


Ala Ile  Leu Glu Ala Cys Leu  Cys Gly Glu Thr Ala  Ile Pro Val 
    1145                 1150                 1155             


Cys Glu  Phe Lys Ala Ala Tyr  Phe Asp Met Ile Arg  Ile Asp Ser 
    1160                 1165                 1170             


Gln Thr  Asn Ser Ser His Leu  Lys Asp Glu Phe Gln  Thr Leu Asn 
    1175                 1180                 1185             


Ser Val  Thr Pro Arg Leu Gln  Ala Glu Asp Cys Ser  Ile Ala Cys 
    1190                 1195                 1200             


Leu Pro  Arg Asn His Asp Lys  Asn Arg Phe Met Asp  Met Leu Pro 
    1205                 1210                 1215             


Pro Asp  Arg Cys Leu Pro Phe  Leu Ile Thr Ile Asp  Gly Glu Ser 
    1220                 1225                 1230             


Ser Asn  Tyr Ile Asn Ala Ala  Leu Met Asp Ser Tyr  Arg Gln Pro 
    1235                 1240                 1245             


Ala Ala  Phe Ile Val Thr Gln  Tyr Pro Leu Pro Asn  Thr Val Lys 
    1250                 1255                 1260             


Asp Phe  Trp Arg Leu Val Tyr  Asp Tyr Gly Cys Thr  Ser Ile Val 
    1265                 1270                 1275             


Met Leu  Asn Glu Val Asp Leu  Ser Gln Gly Cys Pro  Gln Tyr Trp 
    1280                 1285                 1290             


Pro Glu  Glu Gly Met Leu Arg  Tyr Gly Pro Ile Gln  Val Glu Cys 
    1295                 1300                 1305             


Met Ser  Cys Ser Met Asp Cys  Asp Val Ile Asn Arg  Ile Phe Arg 
    1310                 1315                 1320             


Ile Cys  Asn Leu Thr Arg Pro  Gln Glu Gly Tyr Leu  Met Val Gln 
    1325                 1330                 1335             


Gln Phe  Gln Tyr Leu Gly Trp  Ala Ser His Arg Glu  Val Pro Gly 
    1340                 1345                 1350             


Ser Lys  Arg Ser Phe Leu Lys  Leu Ile Leu Gln Val  Glu Lys Trp 
    1355                 1360                 1365             


Gln Glu  Glu Cys Glu Glu Gly  Glu Gly Arg Thr Ile  Ile His Cys 
    1370                 1375                 1380             


Leu Asn  Gly Gly Gly Arg Ser  Gly Met Phe Cys Ala  Ile Gly Ile 
    1385                 1390                 1395             


Val Val  Glu Met Val Lys Arg  Gln Asn Val Val Asp  Val Phe His 
    1400                 1405                 1410             


Ala Val  Lys Thr Leu Arg Asn  Ser Lys Pro Asn Met  Val Glu Ala 
    1415                 1420                 1425             


Pro Glu  Gln Tyr Arg Phe Cys  Tyr Asp Val Ala Leu  Glu Tyr Leu 
    1430                 1435                 1440             


Glu Ser  Ser 
    1445     


<210>  1544
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  1544

Met Ala Ala Ala Ala Glu Leu Ser Leu Leu Glu Lys Ser Leu Gly Leu 
1               5                   10                  15      


Ser Lys Gly Asn Lys Tyr Ser Ala Gln Gly Glu Arg Gln Ile Pro Val 
            20                  25                  30          


Leu Gln Thr Asn Asn Gly Pro Ser Leu Thr Gly Leu Thr Thr Ile Ala 
        35                  40                  45              


Ala His Leu Val Lys Gln Ala Asn Lys Glu Tyr Leu Leu Gly Ser Thr 
    50                  55                  60                  


Ala Glu Glu Lys Ala Ile Val Gln Gln Trp Leu Glu Tyr Arg Val Thr 
65                  70                  75                  80  


Gln Val Asp Gly His Ser Ser Lys Asn Asp Ile His Thr Leu Leu Lys 
                85                  90                  95      


Asp Leu Asn Ser Tyr Leu Glu Asp Lys Val Tyr Leu Thr Gly Tyr Asn 
            100                 105                 110         


Phe Thr Leu Ala Asp Ile Leu Leu Tyr Tyr Gly Leu His Arg Phe Ile 
        115                 120                 125             


Ile Arg Lys Leu Arg His Thr Glu Val Gly Asn 
    130                 135                 


<210>  1545
<211>  1547
<212>  PRT
<213>  Homo sapiens

<400>  1545

Met Gly Thr Ala Leu Leu Gln Arg Gly Gly Cys Phe Leu Leu Cys Leu 
1               5                   10                  15      


Ser Leu Leu Leu Leu Gly Cys Trp Ala Glu Leu Gly Ser Gly Leu Glu 
            20                  25                  30          


Phe Pro Gly Ala Glu Gly Gln Trp Thr Arg Phe Pro Lys Trp Asn Ala 
        35                  40                  45              


Cys Cys Glu Ser Glu Met Ser Phe Gln Leu Lys Thr Arg Ser Ala Arg 
    50                  55                  60                  


Gly Leu Val Leu Tyr Phe Asp Asp Glu Gly Phe Cys Asp Phe Leu Glu 
65                  70                  75                  80  


Leu Ile Leu Thr Arg Gly Gly Arg Leu Gln Leu Ser Phe Ser Ile Phe 
                85                  90                  95      


Cys Ala Glu Pro Ala Thr Leu Leu Ala Asp Thr Pro Val Asn Asp Gly 
            100                 105                 110         


Ala Trp His Ser Val Arg Ile Arg Arg Gln Phe Arg Asn Thr Thr Leu 
        115                 120                 125             


Phe Ile Asp Gln Val Glu Ala Lys Trp Val Glu Val Lys Ser Lys Arg 
    130                 135                 140                 


Arg Asp Met Thr Val Phe Ser Gly Leu Phe Val Gly Gly Leu Pro Pro 
145                 150                 155                 160 


Glu Leu Arg Ala Ala Ala Leu Lys Leu Thr Leu Ala Ser Val Arg Glu 
                165                 170                 175     


Arg Glu Pro Phe Lys Gly Trp Ile Arg Asp Val Arg Val Asn Ser Ser 
            180                 185                 190         


Gln Val Leu Pro Val Asp Ser Gly Glu Val Lys Leu Asp Asp Glu Pro 
        195                 200                 205             


Pro Asn Ser Gly Gly Gly Ser Pro Cys Glu Ala Gly Glu Glu Gly Glu 
    210                 215                 220                 


Gly Gly Val Cys Leu Asn Gly Gly Val Cys Ser Val Val Asp Asp Gln 
225                 230                 235                 240 


Ala Val Cys Asp Cys Ser Arg Thr Gly Phe Arg Gly Lys Asp Cys Ser 
                245                 250                 255     


Gln Glu Ile Lys Phe Gly Leu Gln Cys Val Leu Pro Val Leu Leu His 
            260                 265                 270         


Asp Asn Asp Gln Gly Lys Tyr Cys Cys Ile Asn Thr Ala Lys Pro Leu 
        275                 280                 285             


Thr Glu Lys Asp Asn Asn Val Glu Gly Leu Ala His Leu Met Met Gly 
    290                 295                 300                 


Asp Gln Gly Lys Ser Lys Gly Lys Glu Glu Tyr Ile Ala Thr Phe Lys 
305                 310                 315                 320 


Gly Ser Glu Tyr Phe Cys Tyr Asp Leu Ser Gln Asn Pro Ile Gln Ser 
                325                 330                 335     


Ser Ser Asp Glu Ile Thr Leu Ser Phe Lys Thr Leu Gln Arg Asn Gly 
            340                 345                 350         


Leu Met Leu His Thr Gly Lys Ser Ala Asp Tyr Val Asn Leu Ala Leu 
        355                 360                 365             


Lys Asn Gly Ala Val Ser Leu Val Ile Asn Leu Gly Ser Gly Ala Phe 
    370                 375                 380                 


Glu Ala Leu Val Glu Pro Val Asn Gly Lys Phe Asn Asp Asn Ala Trp 
385                 390                 395                 400 


His Asp Val Lys Val Thr Arg Asn Leu Arg Gln His Ser Gly Ile Gly 
                405                 410                 415     


His Ala Met Val Asn Lys Leu His Cys Ser Val Thr Ile Ser Val Asp 
            420                 425                 430         


Gly Ile Leu Thr Thr Thr Gly Tyr Thr Gln Glu Asp Tyr Thr Met Leu 
        435                 440                 445             


Gly Ser Asp Asp Phe Phe Tyr Val Gly Gly Ser Pro Ser Thr Ala Asp 
    450                 455                 460                 


Leu Pro Gly Ser Pro Val Ser Asn Asn Phe Met Gly Cys Leu Lys Glu 
465                 470                 475                 480 


Val Val Tyr Lys Asn Asn Asp Val Arg Leu Glu Leu Ser Arg Leu Ala 
                485                 490                 495     


Lys Gln Gly Asp Pro Lys Met Lys Ile His Gly Val Val Ala Phe Lys 
            500                 505                 510         


Cys Glu Asn Val Ala Thr Leu Asp Pro Ile Thr Phe Glu Thr Pro Glu 
        515                 520                 525             


Ser Phe Ile Ser Leu Pro Lys Trp Asn Ala Lys Lys Thr Gly Ser Ile 
    530                 535                 540                 


Ser Phe Asp Phe Arg Thr Thr Glu Pro Asn Gly Leu Ile Leu Phe Ser 
545                 550                 555                 560 


His Gly Lys Pro Arg His Gln Lys Asp Ala Lys His Pro Gln Met Ile 
                565                 570                 575     


Lys Val Asp Phe Phe Ala Ile Glu Met Leu Asp Gly His Leu Tyr Leu 
            580                 585                 590         


Leu Leu Asp Met Gly Ser Gly Thr Ile Lys Ile Lys Ala Leu Leu Lys 
        595                 600                 605             


Lys Val Asn Asp Gly Glu Trp Tyr His Val Asp Phe Gln Arg Asp Gly 
    610                 615                 620                 


Arg Ser Gly Thr Ile Ser Val Asn Thr Leu Arg Thr Pro Tyr Thr Ala 
625                 630                 635                 640 


Pro Gly Glu Ser Glu Ile Leu Asp Leu Asp Asp Glu Leu Tyr Leu Gly 
                645                 650                 655     


Gly Leu Pro Glu Asn Lys Ala Gly Leu Val Phe Pro Thr Glu Val Trp 
            660                 665                 670         


Thr Ala Leu Leu Asn Tyr Gly Tyr Val Gly Cys Ile Arg Asp Leu Phe 
        675                 680                 685             


Ile Asp Gly Gln Ser Lys Asp Ile Arg Gln Met Ala Glu Val Gln Ser 
    690                 695                 700                 


Thr Ala Gly Val Lys Pro Ser Cys Ser Lys Glu Thr Ala Lys Pro Cys 
705                 710                 715                 720 


Leu Ser Asn Pro Cys Lys Asn Asn Gly Met Cys Arg Asp Gly Trp Asn 
                725                 730                 735     


Arg Tyr Val Cys Asp Cys Ser Gly Thr Gly Tyr Leu Gly Arg Ser Cys 
            740                 745                 750         


Glu Arg Glu Ala Thr Val Leu Ser Tyr Asp Gly Ser Met Phe Met Lys 
        755                 760                 765             


Ile Gln Leu Pro Val Val Met His Thr Glu Ala Glu Asp Val Ser Leu 
    770                 775                 780                 


Arg Phe Arg Ser Gln Arg Ala Tyr Gly Ile Leu Met Ala Thr Thr Ser 
785                 790                 795                 800 


Arg Asp Ser Ala Asp Thr Leu Arg Leu Glu Leu Asp Ala Gly Arg Val 
                805                 810                 815     


Lys Leu Thr Val Asn Leu Asp Cys Ile Arg Ile Asn Cys Asn Ser Ser 
            820                 825                 830         


Lys Gly Pro Glu Thr Leu Phe Ala Gly Tyr Asn Leu Asn Asp Asn Glu 
        835                 840                 845             


Trp His Thr Val Arg Val Val Arg Arg Gly Lys Ser Leu Lys Leu Thr 
    850                 855                 860                 


Val Asp Asp Gln Gln Ala Met Thr Gly Gln Met Ala Gly Asp His Thr 
865                 870                 875                 880 


Arg Leu Glu Phe His Asn Ile Glu Thr Gly Ile Ile Thr Glu Arg Arg 
                885                 890                 895     


Tyr Leu Ser Ser Val Pro Ser Asn Phe Ile Gly His Leu Gln Ser Leu 
            900                 905                 910         


Thr Phe Asn Gly Met Ala Tyr Ile Asp Leu Cys Lys Asn Gly Asp Ile 
        915                 920                 925             


Asp Tyr Cys Glu Leu Asn Ala Arg Phe Gly Phe Arg Asn Ile Ile Ala 
    930                 935                 940                 


Asp Pro Val Thr Phe Lys Thr Lys Ser Ser Tyr Val Ala Leu Ala Thr 
945                 950                 955                 960 


Leu Gln Ala Tyr Thr Ser Met His Leu Phe Phe Gln Phe Lys Thr Thr 
                965                 970                 975     


Ser Leu Asp Gly Leu Ile Leu Tyr Asn Ser Gly Asp Gly Asn Asp Phe 
            980                 985                 990         


Ile Val Val Glu Leu Val Lys Gly  Tyr Leu His Tyr Val  Phe Asp Leu 
        995                 1000                 1005             


Gly Asn  Gly Ala Asn Leu Ile  Lys Gly Ser Ser Asn  Lys Pro Leu 
    1010                 1015                 1020             


Asn Asp  Asn Gln Trp His Asn  Val Met Ile Ser Arg  Asp Thr Ser 
    1025                 1030                 1035             


Asn Leu  His Thr Val Lys Ile  Asp Thr Lys Ile Thr  Thr Gln Ile 
    1040                 1045                 1050             


Thr Ala  Gly Ala Arg Asn Leu  Asp Leu Lys Ser Asp  Leu Tyr Ile 
    1055                 1060                 1065             


Gly Gly  Val Ala Lys Glu Thr  Tyr Lys Ser Leu Pro  Lys Leu Val 
    1070                 1075                 1080             


His Ala  Lys Glu Gly Phe Gln  Gly Cys Leu Ala Ser  Val Asp Leu 
    1085                 1090                 1095             


Asn Gly  Arg Leu Pro Asp Leu  Ile Ser Asp Ala Leu  Phe Cys Asn 
    1100                 1105                 1110             


Gly Gln  Ile Glu Arg Gly Cys  Glu Gly Pro Ser Thr  Thr Cys Gln 
    1115                 1120                 1125             


Glu Asp  Ser Cys Ser Asn Gln  Gly Val Cys Leu Gln  Gln Trp Asp 
    1130                 1135                 1140             


Gly Phe  Ser Cys Asp Cys Ser  Met Thr Ser Phe Ser  Gly Pro Leu 
    1145                 1150                 1155             


Cys Asn  Asp Pro Gly Thr Thr  Tyr Ile Phe Ser Lys  Gly Gly Gly 
    1160                 1165                 1170             


Gln Ile  Thr Tyr Lys Trp Pro  Pro Asn Asp Arg Pro  Ser Thr Arg 
    1175                 1180                 1185             


Ala Asp  Arg Leu Ala Ile Gly  Phe Ser Thr Val Gln  Lys Glu Ala 
    1190                 1195                 1200             


Val Leu  Val Arg Val Asp Ser  Ser Ser Gly Leu Gly  Asp Tyr Leu 
    1205                 1210                 1215             


Glu Leu  His Ile His Gln Gly  Lys Ile Gly Val Lys  Phe Asn Val 
    1220                 1225                 1230             


Gly Thr  Asp Asp Ile Ala Ile  Glu Glu Ser Asn Ala  Ile Ile Asn 
    1235                 1240                 1245             


Asp Gly  Lys Tyr His Val Val  Arg Phe Thr Arg Ser  Gly Gly Asn 
    1250                 1255                 1260             


Ala Thr  Leu Gln Val Asp Ser  Trp Pro Val Ile Glu  Arg Tyr Pro 
    1265                 1270                 1275             


Ala Gly  Asn Asn Asp Asn Glu  Arg Leu Ala Ile Ala  Arg Gln Arg 
    1280                 1285                 1290             


Ile Pro  Tyr Arg Leu Gly Arg  Val Val Asp Glu Trp  Leu Leu Asp 
    1295                 1300                 1305             


Lys Gly  Arg Gln Leu Thr Ile  Phe Asn Ser Gln Ala  Thr Ile Ile 
    1310                 1315                 1320             


Ile Gly  Gly Lys Glu Gln Gly  Gln Pro Phe Gln Gly  Gln Leu Ser 
    1325                 1330                 1335             


Gly Leu  Tyr Tyr Asn Gly Leu  Lys Val Leu Asn Met  Ala Ala Glu 
    1340                 1345                 1350             


Asn Asp  Ala Asn Ile Ala Ile  Val Gly Asn Val Arg  Leu Val Gly 
    1355                 1360                 1365             


Glu Val  Pro Ser Ser Met Thr  Thr Glu Ser Thr Ala  Thr Ala Met 
    1370                 1375                 1380             


Gln Ser  Glu Met Ser Thr Ser  Ile Met Glu Thr Thr  Thr Thr Leu 
    1385                 1390                 1395             


Ala Thr  Ser Thr Ala Arg Arg  Gly Lys Pro Pro Thr  Lys Glu Pro 
    1400                 1405                 1410             


Ile Ser  Gln Thr Thr Asp Asp  Ile Leu Val Ala Ser  Ala Glu Cys 
    1415                 1420                 1425             


Pro Ser  Asp Asp Glu Asp Ile  Asp Pro Cys Glu Pro  Ser Ser Gly 
    1430                 1435                 1440             


Gly Leu  Ala Asn Pro Thr Arg  Ala Gly Gly Arg Glu  Pro Tyr Pro 
    1445                 1450                 1455             


Gly Ser  Ala Glu Val Ile Arg  Glu Ser Ser Ser Thr  Thr Gly Met 
    1460                 1465                 1470             


Val Val  Gly Ile Val Ala Ala  Ala Ala Leu Cys Ile  Leu Ile Leu 
    1475                 1480                 1485             


Leu Tyr  Ala Met Tyr Lys Tyr  Arg Asn Arg Asp Glu  Gly Ser Tyr 
    1490                 1495                 1500             


His Val  Asp Glu Ser Arg Asn  Tyr Ile Ser Asn Ser  Ala Gln Ser 
    1505                 1510                 1515             


Asn Gly  Ala Val Val Lys Glu  Lys Gln Pro Ser Ser  Ala Lys Ser 
    1520                 1525                 1530             


Ser Asn  Lys Asn Lys Lys Asn  Lys Asp Lys Glu Tyr  Tyr Val 
    1535                 1540                 1545         


<210>  1546
<211>  631
<212>  PRT
<213>  Homo sapiens

<400>  1546

Met Lys Phe Ala Glu His Leu Ser Ala His Ile Thr Pro Glu Trp Arg 
1               5                   10                  15      


Lys Gln Tyr Ile Gln Tyr Glu Ala Phe Lys Asp Met Leu Tyr Ser Ala 
            20                  25                  30          


Gln Asp Gln Ala Pro Ser Val Glu Val Thr Asp Glu Asp Thr Val Lys 
        35                  40                  45              


Arg Tyr Phe Ala Lys Phe Glu Glu Lys Phe Phe Gln Thr Cys Glu Lys 
    50                  55                  60                  


Glu Leu Ala Lys Ile Asn Thr Phe Tyr Ser Glu Lys Leu Ala Glu Ala 
65                  70                  75                  80  


Gln Arg Arg Phe Ala Thr Leu Gln Asn Glu Leu Gln Ser Ser Leu Asp 
                85                  90                  95      


Ala Gln Lys Glu Ser Thr Gly Val Thr Thr Leu Arg Gln Arg Arg Lys 
            100                 105                 110         


Pro Val Phe His Leu Ser His Glu Glu Arg Val Gln His Arg Asn Ile 
        115                 120                 125             


Lys Asp Leu Lys Leu Ala Phe Ser Glu Phe Tyr Leu Ser Leu Ile Leu 
    130                 135                 140                 


Leu Gln Asn Tyr Gln Asn Leu Asn Phe Thr Gly Phe Arg Lys Ile Leu 
145                 150                 155                 160 


Lys Lys His Asp Lys Ile Leu Glu Thr Ser Arg Gly Ala Asp Trp Arg 
                165                 170                 175     


Val Ala His Val Glu Val Ala Pro Phe Tyr Thr Cys Lys Lys Ile Asn 
            180                 185                 190         


Gln Leu Ile Ser Glu Thr Glu Ala Val Val Thr Asn Glu Leu Glu Asp 
        195                 200                 205             


Gly Asp Arg Gln Lys Ala Met Lys Arg Leu Arg Val Pro Pro Leu Gly 
    210                 215                 220                 


Ala Ala Gln Pro Ala Pro Ala Trp Thr Thr Phe Arg Val Gly Leu Phe 
225                 230                 235                 240 


Cys Gly Ile Phe Ile Val Leu Asn Ile Thr Leu Val Leu Ala Ala Val 
                245                 250                 255     


Phe Lys Leu Glu Thr Asp Arg Ser Ile Trp Pro Leu Ile Arg Ile Tyr 
            260                 265                 270         


Arg Gly Gly Phe Leu Leu Ile Glu Phe Leu Phe Leu Leu Gly Ile Asn 
        275                 280                 285             


Thr Tyr Gly Trp Arg Gln Ala Gly Val Asn His Val Leu Ile Phe Glu 
    290                 295                 300                 


Leu Asn Pro Arg Ser Asn Leu Ser His Gln His Leu Phe Glu Ile Ala 
305                 310                 315                 320 


Gly Phe Leu Gly Ile Leu Trp Cys Leu Ser Leu Leu Ala Cys Phe Phe 
                325                 330                 335     


Ala Pro Ile Ser Val Ile Pro Thr Tyr Val Tyr Pro Leu Ala Leu Tyr 
            340                 345                 350         


Gly Phe Met Val Phe Phe Leu Ile Asn Pro Thr Lys Thr Phe Tyr Tyr 
        355                 360                 365             


Lys Ser Arg Phe Trp Leu Leu Lys Leu Leu Phe Arg Val Phe Thr Ala 
    370                 375                 380                 


Pro Phe His Lys Val Gly Phe Ala Asp Phe Trp Leu Ala Asp Gln Leu 
385                 390                 395                 400 


Asn Ser Leu Ser Val Ile Leu Met Asp Leu Glu Tyr Met Ile Cys Phe 
                405                 410                 415     


Tyr Ser Leu Glu Leu Lys Trp Asp Glu Ser Lys Gly Leu Leu Pro Asn 
            420                 425                 430         


Asn Ser Glu Glu Arg Gly His Ser Asp Thr Met Val Phe Phe Tyr Leu 
        435                 440                 445             


Trp Ile Val Phe Tyr Ile Ile Ser Ser Cys Tyr Thr Leu Ile Trp Asp 
    450                 455                 460                 


Leu Lys Met Asp Trp Gly Leu Phe Asp Lys Asn Ala Gly Glu Asn Thr 
465                 470                 475                 480 


Phe Leu Arg Glu Glu Ile Val Tyr Pro Gln Lys Ala Tyr Tyr Tyr Cys 
                485                 490                 495     


Ala Ile Ile Glu Asp Val Ile Leu Arg Phe Ala Trp Thr Ile Gln Ile 
            500                 505                 510         


Ser Ile Thr Ser Thr Thr Leu Leu Pro His Ser Gly Asp Ile Ile Ala 
        515                 520                 525             


Thr Val Phe Ala Pro Leu Glu Val Phe Arg Arg Phe Val Trp Asn Phe 
    530                 535                 540                 


Phe Arg Leu Glu Asn Glu His Leu Asn Asn Cys Gly Glu Phe Arg Ala 
545                 550                 555                 560 


Val Arg Asp Ile Ser Val Ala Pro Leu Asn Ala Asp Asp Gln Thr Leu 
                565                 570                 575     


Leu Glu Gln Met Met Asp Gln Asp Asp Gly Val Arg Asn Arg Gln Lys 
            580                 585                 590         


Asn Arg Ser Trp Lys Tyr Asn Gln Ser Ile Ser Leu Arg Arg Pro Arg 
        595                 600                 605             


Leu Ala Ser Gln Ser Lys Ala Arg Asp Thr Lys Val Leu Ile Glu Asp 
    610                 615                 620                 


Thr Asp Asp Glu Ala Asn Thr 
625                 630     


<210>  1547
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  1547

Met Glu Asp Lys Arg Asn Ile Gln Ile Ile Glu Trp Glu His Leu Asp 
1               5                   10                  15      


Lys Lys Lys Phe Tyr Val Phe Gly Val Ala Met Thr Met Met Ile Arg 
            20                  25                  30          


Val Ser Val Tyr Pro Phe Thr Leu Ile Arg Thr Arg Leu Gln Val Gln 
        35                  40                  45              


Lys Gly Lys Ser Leu Tyr His Gly Thr Phe Asp Ala Phe Ile Lys Ile 
    50                  55                  60                  


Leu Arg Ala Asp Gly Ile Thr Gly Leu Tyr Arg Gly Phe Leu Val Asn 
65                  70                  75                  80  


Thr Phe Thr Leu Ile Ser Gly Gln Cys Tyr Val Thr Thr Tyr Glu Leu 
                85                  90                  95      


Thr Arg Lys Phe Val Ala Asp Tyr Ser Gln Ser Asn Thr Val Lys Ser 
            100                 105                 110         


Leu Val Ala Gly Gly Ser Ala Ser Leu Val Ala Gln Ser Ile Thr Val 
        115                 120                 125             


Pro Ile Asp Val Val Ser Gln His Leu Met Met Gln Arg Lys Gly Glu 
    130                 135                 140                 


Lys Met Gly Arg Phe Gln Val Arg Gly Asn Pro Glu Gly Gln Gly Val 
145                 150                 155                 160 


Val Ala Phe Gly Gln Thr Lys Asp Ile Ile Arg Gln Ile Leu Gln Ala 
                165                 170                 175     


Asp Gly Leu Arg Gly Phe Tyr Arg Gly Tyr Val Ala Ser Leu Leu Thr 
            180                 185                 190         


Tyr Ile Pro Asn Ser Ala Val Trp Trp Pro Phe Tyr His Phe Tyr Ala 
        195                 200                 205             


Ala Ile Val Phe Pro Trp Ile Pro Glu Gln Leu Ser Tyr Leu Cys Pro 
    210                 215                 220                 


Lys Glu Cys Pro His Ile Val Phe Gln Ala Val Ser Gly Pro Leu Ala 
225                 230                 235                 240 


Ala Ala Thr Ala Ser Ile Leu Thr Asn Pro Met Asp Val Ile Arg Thr 
                245                 250                 255     


Arg Val Gln Val Glu Gly Lys Asn Ser Ile Ile Leu Thr Phe Arg Gln 
            260                 265                 270         


Leu Met Ala Glu Glu Gly Pro Trp Gly Leu Met Lys Gly Leu Ser Ala 
        275                 280                 285             


Arg Ile Ile Ser Ala Thr Pro Ser Thr Ile Val Ile Val Val Gly Tyr 
    290                 295                 300                 


Glu Ser Leu Lys Lys Leu Ser Leu Arg Pro Glu Leu Val Asp Ser Arg 
305                 310                 315                 320 


His Trp 
        


<210>  1548
<211>  583
<212>  PRT
<213>  Homo sapiens

<400>  1548

Met Ala Glu Gly Asp Glu Ala Ala Arg Gly Gln Gln Pro His Gln Gly 
1               5                   10                  15      


Leu Trp Arg Arg Arg Arg Thr Ser Asp Pro Ser Ala Ala Val Asn His 
            20                  25                  30          


Val Ser Ser Thr Thr Ser Leu Gly Glu Asn Tyr Glu Asp Asp Asp Leu 
        35                  40                  45              


Val Asn Ser Asp Glu Val Met Lys Lys Pro Cys Pro Val Gln Ile Val 
    50                  55                  60                  


Leu Ala His Glu Asp Asp His Asn Phe Glu Leu Asp Glu Glu Ala Leu 
65                  70                  75                  80  


Glu Gln Ile Leu Leu Gln Glu His Ile Arg Asp Leu Asn Ile Val Val 
                85                  90                  95      


Val Ser Val Ala Gly Ala Phe Arg Lys Gly Lys Ser Phe Leu Leu Asp 
            100                 105                 110         


Phe Met Leu Arg Tyr Met Tyr Asn Lys Asp Ser Gln Ser Trp Ile Gly 
        115                 120                 125             


Gly Asn Asn Glu Pro Leu Thr Gly Phe Thr Trp Arg Gly Gly Cys Glu 
    130                 135                 140                 


Arg Glu Thr Thr Gly Ile Gln Val Trp Asn Glu Val Phe Val Ile Asp 
145                 150                 155                 160 


Arg Pro Asn Gly Thr Lys Val Ala Val Leu Leu Met Asp Thr Gln Gly 
                165                 170                 175     


Ala Phe Asp Ser Gln Ser Thr Ile Lys Asp Cys Ala Thr Val Phe Ala 
            180                 185                 190         


Leu Ser Thr Met Thr Ser Ser Val Gln Val Tyr Asn Leu Ser Gln Asn 
        195                 200                 205             


Ile Gln Glu Asp Asp Leu Gln His Leu Gln Leu Phe Thr Glu Tyr Gly 
    210                 215                 220                 


Arg Leu Ala Met Glu Glu Ile Tyr Gln Lys Pro Phe Gln Thr Leu Met 
225                 230                 235                 240 


Phe Leu Ile Arg Asp Trp Ser Tyr Pro Tyr Glu His Ser Tyr Gly Leu 
                245                 250                 255     


Glu Gly Gly Lys Gln Phe Leu Glu Lys Arg Leu Gln Val Lys Gln Asn 
            260                 265                 270         


Gln His Glu Glu Leu Gln Asn Val Arg Lys His Ile His Asn Cys Phe 
        275                 280                 285             


Ser Asn Leu Gly Cys Phe Leu Leu Pro His Pro Gly Leu Lys Val Ala 
    290                 295                 300                 


Thr Asn Pro Ser Phe Asp Gly Arg Leu Lys Asp Ile Asp Glu Asp Phe 
305                 310                 315                 320 


Lys Arg Glu Leu Arg Asn Leu Val Pro Leu Leu Leu Ala Pro Glu Asn 
                325                 330                 335     


Leu Val Glu Lys Glu Ile Ser Gly Ser Lys Val Thr Cys Arg Asp Leu 
            340                 345                 350         


Val Glu Tyr Phe Lys Ala Tyr Ile Lys Ile Tyr Gln Gly Glu Glu Leu 
        355                 360                 365             


Pro His Pro Lys Ser Met Leu Gln Ala Thr Ala Glu Ala Asn Asn Leu 
    370                 375                 380                 


Ala Ala Val Ala Gly Ala Arg Asp Thr Tyr Cys Lys Ser Met Glu Gln 
385                 390                 395                 400 


Val Cys Gly Gly Asp Lys Pro Tyr Ile Ala Pro Ser Asp Leu Glu Arg 
                405                 410                 415     


Lys His Leu Asp Leu Lys Glu Val Ala Ile Lys Gln Phe Arg Ser Val 
            420                 425                 430         


Lys Lys Met Gly Gly Asp Glu Phe Cys Arg Arg Tyr Gln Asp Gln Leu 
        435                 440                 445             


Glu Ala Glu Ile Glu Glu Thr Tyr Ala Asn Phe Ile Lys His Asn Asp 
    450                 455                 460                 


Gly Lys Asn Ile Phe Tyr Ala Ala Arg Thr Pro Ala Thr Leu Phe Ala 
465                 470                 475                 480 


Val Met Phe Ala Met Tyr Ile Ile Ser Gly Leu Thr Gly Phe Ile Gly 
                485                 490                 495     


Leu Asn Ser Ile Ala Val Leu Cys Asn Leu Val Met Gly Leu Ala Leu 
            500                 505                 510         


Ile Phe Leu Cys Thr Trp Ala Tyr Val Lys Tyr Ser Gly Glu Phe Arg 
        515                 520                 525             


Glu Ile Gly Thr Val Ile Asp Gln Ile Ala Glu Thr Leu Trp Glu Gln 
    530                 535                 540                 


Val Leu Lys Pro Leu Gly Asp Asn Leu Met Glu Glu Asn Ile Arg Gln 
545                 550                 555                 560 


Ser Val Thr Asn Ser Ile Lys Ala Gly Leu Thr Asp Gln Val Ser His 
                565                 570                 575     


His Ala Arg Leu Lys Thr Asp 
            580             


<210>  1549
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  1549

Met Ala Gly Gly Tyr Gly Val Met Gly Asp Asp Gly Ser Ile Asp Tyr 
1               5                   10                  15      


Thr Val His Glu Ala Trp Asn Glu Ala Thr Asn Val Tyr Leu Ile Val 
            20                  25                  30          


Ile Leu Val Ser Phe Gly Leu Phe Met Tyr Ala Lys Arg Asn Lys Arg 
        35                  40                  45              


Arg Ile Met Arg Ile Phe Ser Val Pro Pro Thr Glu Glu Thr Leu Ser 
    50                  55                  60                  


Glu Pro Asn Phe Tyr Asp Thr Ile Ser Lys Ile Arg Leu Arg Gln Gln 
65                  70                  75                  80  


Leu Glu Met Tyr Ser Ile Ser Arg Lys Tyr Asp Tyr Gln Gln Pro Gln 
                85                  90                  95      


Asn Gln Ala Asp Ser Val Gln Leu Ser Leu Glu 
            100                 105         


<210>  1550
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  1550

Met Ala Gly Gly Tyr Gly Val Met Gly Asp Asp Gly Ser Ile Asp Tyr 
1               5                   10                  15      


Thr Val His Glu Ala Trp Asn Glu Ala Thr Asn Val Tyr Leu Ile Val 
            20                  25                  30          


Ile Leu Val Ser Phe Gly Leu Phe Met Tyr Ala Lys Arg Asn Lys Arg 
        35                  40                  45              


Arg Ile Met Arg Ile Phe Ser Val Pro Pro Thr Glu Glu Thr Leu Ser 
    50                  55                  60                  


Glu Pro Asn Phe Tyr Asp Thr Ile Ser Lys Ile Arg Leu Arg Gln Gln 
65                  70                  75                  80  


Leu Glu Met Tyr Ser Ile Ser Arg Lys Tyr Asp Tyr Gln Gln Pro Gln 
                85                  90                  95      


Asn Gln Ala Asp Ser Val Gln Leu Ser Leu Glu 
            100                 105         


<210>  1551
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  1551

Met Ala Gly Gly Tyr Gly Val Met Gly Asp Asp Gly Ser Ile Asp Tyr 
1               5                   10                  15      


Thr Val His Glu Ala Trp Asn Glu Ala Thr Asn Val Tyr Leu Ile Val 
            20                  25                  30          


Ile Leu Val Ser Phe Gly Leu Phe Met Tyr Ala Lys Arg Asn Lys Arg 
        35                  40                  45              


Arg Ile Met Arg Ile Phe Ser Val Pro Pro Thr Glu Glu Thr Leu Ser 
    50                  55                  60                  


Glu Pro Asn Phe Tyr Asp Thr Ile Ser Lys Ile Arg Leu Arg Gln Gln 
65                  70                  75                  80  


Leu Glu Met Tyr Ser Ile Ser Arg Lys Tyr Asp Tyr Gln Gln Pro Gln 
                85                  90                  95      


Asn Gln Ala Asp Ser Val Gln Leu Ser Leu Glu 
            100                 105         


<210>  1552
<211>  734
<212>  PRT
<213>  Homo sapiens

<400>  1552

Met Gly Cys Trp Gly Gln Leu Leu Val Trp Phe Gly Ala Ala Gly Ala 
1               5                   10                  15      


Ile Leu Cys Ser Ser Pro Gly Ser Gln Glu Thr Phe Leu Arg Ser Ser 
            20                  25                  30          


Pro Leu Pro Leu Ala Ser Pro Ser Pro Arg Asp Pro Lys Val Ser Ala 
        35                  40                  45              


Pro Pro Ser Ile Leu Glu Pro Ala Ser Pro Leu Asn Ser Pro Gly Thr 
    50                  55                  60                  


Glu Gly Ser Trp Leu Phe Ser Thr Cys Gly Ala Ser Gly Arg His Gly 
65                  70                  75                  80  


Pro Thr Gln Thr Gln Cys Asp Gly Ala Tyr Ala Gly Thr Ser Val Val 
                85                  90                  95      


Val Thr Val Gly Ala Ala Gly Gln Leu Arg Gly Val Gln Leu Trp Arg 
            100                 105                 110         


Val Pro Gly Pro Gly Gln Tyr Leu Ile Ser Ala Tyr Gly Ala Ala Gly 
        115                 120                 125             


Gly Lys Gly Ala Lys Asn His Leu Ser Arg Ala His Gly Val Phe Val 
    130                 135                 140                 


Ser Ala Ile Phe Ser Leu Gly Leu Gly Glu Ser Leu Tyr Ile Leu Val 
145                 150                 155                 160 


Gly Gln Gln Gly Glu Asp Ala Cys Pro Gly Gly Ser Pro Glu Ser Gln 
                165                 170                 175     


Leu Val Cys Leu Gly Glu Ser Arg Ala Val Glu Glu His Ala Ala Met 
            180                 185                 190         


Asp Gly Ser Glu Gly Val Pro Gly Ser Arg Arg Trp Ala Gly Gly Gly 
        195                 200                 205             


Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Arg Val Arg Ala Gly Glu 
    210                 215                 220                 


Leu Glu Pro Leu Leu Val Ala Ala Gly Gly Gly Gly Arg Ala Tyr Leu 
225                 230                 235                 240 


Arg Pro Arg Asp Arg Gly Arg Thr Gln Ala Ser Pro Glu Lys Leu Glu 
                245                 250                 255     


Asn Arg Ser Glu Ala Pro Gly Ser Gly Gly Arg Gly Gly Ala Ala Gly 
            260                 265                 270         


Gly Asp Ala Ser Glu Thr Asp Asn Leu Trp Ala Asp Gly Glu Asp Gly 
        275                 280                 285             


Val Ser Phe Ile His Pro Ser Ser Glu Leu Phe Leu Gln Pro Leu Ala 
    290                 295                 300                 


Val Thr Glu Asn His Gly Glu Val Glu Ile Arg Arg His Leu Asn Cys 
305                 310                 315                 320 


Ser His Cys Pro Leu Arg Asp Cys Gln Trp Gln Ala Glu Leu Gln Leu 
                325                 330                 335     


Ala Glu Cys Leu Cys Pro Glu Gly Met Glu Leu Ala Val Asp Asn Val 
            340                 345                 350         


Thr Cys Met Asp Leu His Lys Pro Pro Gly Pro Leu Val Leu Met Val 
        355                 360                 365             


Ala Val Val Ala Thr Ser Thr Leu Ser Leu Leu Met Val Cys Gly Val 
    370                 375                 380                 


Leu Ile Leu Gly Gly Ala Trp Pro Gly Pro Val Leu Ala Ser Ala Thr 
385                 390                 395                 400 


Arg Cys His Arg Gly Phe Pro Ser Gln Cys Tyr Ser Ala Gln Thr Leu 
                405                 410                 415     


Pro Glu Leu Cys Ser Pro Gln Asp Glu Leu Asp Phe Leu Met Glu Ala 
            420                 425                 430         


Leu Ile Ile Ser Lys Phe Arg His Gln Asn Ile Val Arg Cys Val Gly 
        435                 440                 445             


Leu Ser Leu Arg Ala Thr Pro Arg Leu Ile Leu Leu Glu Leu Met Ser 
    450                 455                 460                 


Gly Gly Asp Met Lys Ser Phe Leu Arg His Ser Arg Pro His Leu Gly 
465                 470                 475                 480 


Gln Pro Ser Pro Leu Val Met Arg Asp Leu Leu Gln Leu Ala Gln Asp 
                485                 490                 495     


Ile Ala Gln Gly Cys His Tyr Leu Glu Glu Asn His Phe Ile His Arg 
            500                 505                 510         


Asp Ile Ala Ala Arg Asn Cys Leu Leu Ser Cys Ala Gly Pro Ser Arg 
        515                 520                 525             


Val Ala Lys Ile Gly Asp Phe Gly Met Ala Arg Asp Ile Tyr Arg Ala 
    530                 535                 540                 


Ser Tyr Tyr Arg Arg Gly Asp Arg Ala Leu Leu Pro Val Lys Trp Met 
545                 550                 555                 560 


Pro Pro Glu Ala Phe Leu Glu Gly Ile Phe Thr Ser Lys Thr Asp Ser 
                565                 570                 575     


Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Ser Leu Gly Tyr Met 
            580                 585                 590         


Pro Tyr Pro Gly Arg Thr Asn Gln Glu Val Leu Asp Phe Val Val Gly 
        595                 600                 605             


Gly Gly Arg Met Asp Pro Pro Arg Gly Cys Pro Gly Pro Val Tyr Arg 
    610                 615                 620                 


Ile Met Thr Gln Cys Trp Gln His Glu Pro Glu Leu Arg Pro Ser Phe 
625                 630                 635                 640 


Ala Ser Ile Leu Glu Arg Leu Gln Tyr Cys Thr Gln Asp Pro Asp Val 
                645                 650                 655     


Leu Asn Ser Leu Leu Pro Met Glu Leu Gly Pro Thr Pro Glu Glu Glu 
            660                 665                 670         


Gly Thr Ser Gly Leu Gly Asn Arg Ser Leu Glu Cys Leu Arg Pro Pro 
        675                 680                 685             


Gln Pro Gln Glu Leu Ser Pro Glu Lys Leu Lys Ser Trp Gly Gly Ser 
    690                 695                 700                 


Pro Leu Gly Pro Trp Leu Ser Ser Gly Leu Lys Pro Leu Lys Ser Arg 
705                 710                 715                 720 


Gly Leu Gln Pro Gln Asn Leu Trp Asn Pro Thr Tyr Arg Ser 
                725                 730                 


<210>  1553
<211>  525
<212>  PRT
<213>  Homo sapiens

<400>  1553

Met Leu Arg Thr Ile Leu Asp Ala Pro Gln Arg Leu Leu Lys Glu Gly 
1               5                   10                  15      


Arg Ala Ser Arg Gln Leu Val Leu Val Val Val Phe Val Ala Leu Leu 
            20                  25                  30          


Leu Asp Asn Met Leu Phe Thr Val Val Val Pro Ile Val Pro Thr Phe 
        35                  40                  45              


Leu Tyr Asp Met Glu Phe Lys Glu Val Asn Ser Ser Leu His Leu Gly 
    50                  55                  60                  


His Ala Gly Ser Ser Pro His Ala Leu Ala Ser Pro Ala Phe Ser Thr 
65                  70                  75                  80  


Ile Phe Ser Phe Phe Asn Asn Asn Thr Val Ala Val Glu Glu Ser Val 
                85                  90                  95      


Pro Ser Gly Ile Ala Trp Met Asn Asp Thr Ala Ser Thr Ile Pro Pro 
            100                 105                 110         


Pro Ala Thr Glu Ala Ile Ser Ala His Lys Asn Asn Cys Leu Gln Gly 
        115                 120                 125             


Thr Gly Phe Leu Glu Glu Glu Ile Thr Arg Val Gly Val Leu Phe Ala 
    130                 135                 140                 


Ser Lys Ala Val Met Gln Leu Leu Val Asn Pro Phe Val Gly Pro Leu 
145                 150                 155                 160 


Thr Asn Arg Ile Gly Tyr His Ile Pro Met Phe Ala Gly Phe Val Ile 
                165                 170                 175     


Met Phe Leu Ser Thr Val Met Phe Ala Phe Ser Gly Thr Tyr Thr Leu 
            180                 185                 190         


Leu Phe Val Ala Arg Thr Leu Gln Gly Ile Gly Ser Ser Phe Ser Ser 
        195                 200                 205             


Val Ala Gly Leu Gly Met Leu Ala Ser Val Tyr Thr Asp Asp His Glu 
    210                 215                 220                 


Arg Gly Arg Ala Met Gly Thr Ala Leu Gly Gly Leu Ala Leu Gly Leu 
225                 230                 235                 240 


Leu Val Gly Ala Pro Phe Gly Ser Val Met Tyr Glu Phe Val Gly Lys 
                245                 250                 255     


Ser Ala Pro Phe Leu Ile Leu Ala Phe Leu Ala Leu Leu Asp Gly Ala 
            260                 265                 270         


Leu Gln Leu Cys Ile Leu Gln Pro Ser Lys Val Ser Pro Glu Ser Ala 
        275                 280                 285             


Lys Gly Thr Pro Leu Phe Met Leu Leu Lys Asp Pro Tyr Ile Leu Val 
    290                 295                 300                 


Ala Ala Gly Ser Ile Cys Phe Ala Asn Met Gly Val Ala Ile Leu Glu 
305                 310                 315                 320 


Pro Thr Leu Pro Ile Trp Met Met Gln Thr Met Cys Ser Pro Lys Trp 
                325                 330                 335     


Gln Leu Gly Leu Ala Phe Leu Pro Ala Ser Val Ser Tyr Leu Ile Gly 
            340                 345                 350         


Thr Asn Leu Phe Gly Val Leu Ala Asn Lys Met Gly Arg Trp Leu Cys 
        355                 360                 365             


Ser Leu Ile Gly Met Leu Val Val Gly Thr Ser Leu Leu Cys Val Pro 
    370                 375                 380                 


Leu Ala His Asn Ile Phe Gly Leu Ile Gly Pro Asn Ala Gly Leu Gly 
385                 390                 395                 400 


Leu Ala Ile Gly Met Val Asp Ser Ser Met Met Pro Ile Met Gly His 
                405                 410                 415     


Leu Val Asp Leu Arg His Thr Ser Val Tyr Gly Ser Val Tyr Ala Ile 
            420                 425                 430         


Ala Asp Val Ala Phe Cys Met Gly Phe Ala Ile Gly Pro Ser Thr Gly 
        435                 440                 445             


Gly Ala Ile Val Lys Ala Ile Gly Phe Pro Trp Leu Met Val Ile Thr 
    450                 455                 460                 


Gly Val Ile Asn Ile Val Tyr Ala Pro Leu Cys Tyr Tyr Leu Arg Ser 
465                 470                 475                 480 


Pro Pro Ala Lys Glu Glu Lys Leu Ala Ile Leu Ser Gln Asp Cys Pro 
                485                 490                 495     


Met Glu Thr Arg Met Tyr Ala Thr Gln Lys Pro Thr Lys Glu Phe Pro 
            500                 505                 510         


Leu Gly Glu Asp Ser Asp Glu Glu Pro Asp His Glu Glu 
        515                 520                 525 


<210>  1554
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  1554

Met Ala Glu Thr Leu Phe Trp Thr Pro Leu Leu Val Val Leu Leu Ala 
1               5                   10                  15      


Gly Leu Gly Asp Thr Glu Ala Gln Gln Thr Thr Leu His Pro Leu Val 
            20                  25                  30          


Gly Arg Val Phe Val His Thr Leu Asp His Glu Thr Phe Leu Ser Leu 
        35                  40                  45              


Pro Glu His Val Ala Val Pro Pro Ala Val His Ile Thr Tyr His Ala 
    50                  55                  60                  


His Leu Gln Gly His Pro Asp Leu Pro Arg Trp Leu Arg Tyr Thr Gln 
65                  70                  75                  80  


Arg Ser Pro His His Pro Gly Phe Leu Tyr Gly Ser Ala Thr Pro Glu 
                85                  90                  95      


Asp Arg Gly Leu Gln Val Ile Glu Val Thr Ala Tyr Asn Arg Asp Ser 
            100                 105                 110         


Phe Asp Thr Thr Arg Gln Arg Leu Val Leu Glu Ile Gly Asp Pro Glu 
        115                 120                 125             


Gly Pro Leu Leu Pro Tyr Gln Ala Glu Phe Leu Val Arg Ser His Asp 
    130                 135                 140                 


Ala Glu Glu Val Leu Pro Ser Thr Pro Ala Ser Arg Phe Leu Ser Ala 
145                 150                 155                 160 


Leu Gly Gly Leu Trp Glu Pro Gly Glu Leu Gln Leu Leu Asn Val Thr 
                165                 170                 175     


Ser Ala Leu Asp Arg Gly Gly Arg Val Pro Leu Pro Ile Glu Gly Arg 
            180                 185                 190         


Lys Glu Gly Leu Lys Arg Asp Leu Ala Thr Ser Asp Ile Gln Met Val 
        195                 200                 205             


His His Cys Thr Ile His Gly Asn Thr Glu Glu Leu Arg Gln Met Ala 
    210                 215                 220                 


Ala Ser Arg Glu Val Pro Arg Pro Leu Ser Thr Leu Pro Met Phe Asn 
225                 230                 235                 240 


Val His Thr Gly Glu Arg Leu Pro Pro Arg Val Asp Ser Ala Gln Val 
                245                 250                 255     


Pro Leu Ile Leu Asp Gln His 
            260             


<210>  1555
<211>  840
<212>  PRT
<213>  Homo sapiens

<400>  1555

Met Ala Cys Arg Trp Ser Thr Lys Glu Ser Pro Arg Trp Arg Ser Ala 
1               5                   10                  15      


Leu Leu Leu Leu Phe Leu Ala Gly Val Tyr Ala Cys Gly Glu Thr Pro 
            20                  25                  30          


Glu Gln Ile Arg Ala Pro Ser Gly Ile Ile Thr Ser Pro Gly Trp Pro 
        35                  40                  45              


Ser Glu Tyr Pro Ala Lys Ile Asn Cys Ser Trp Phe Ile Arg Ala Asn 
    50                  55                  60                  


Pro Gly Glu Ile Ile Thr Ile Ser Phe Gln Asp Phe Asp Ile Gln Gly 
65                  70                  75                  80  


Ser Arg Arg Cys Asn Leu Asp Trp Leu Thr Ile Glu Thr Tyr Lys Asn 
                85                  90                  95      


Ile Glu Ser Tyr Arg Ala Cys Gly Ser Thr Ile Pro Pro Pro Tyr Ile 
            100                 105                 110         


Ser Ser Gln Asp His Ile Trp Ile Arg Phe His Ser Asp Asp Asn Ile 
        115                 120                 125             


Ser Arg Lys Gly Phe Arg Leu Ala Tyr Phe Ser Gly Lys Ser Glu Glu 
    130                 135                 140                 


Pro Asn Cys Ala Cys Asp Gln Phe Arg Cys Gly Asn Gly Lys Cys Ile 
145                 150                 155                 160 


Pro Glu Ala Trp Lys Cys Asn Asn Met Asp Glu Cys Gly Asp Ser Ser 
                165                 170                 175     


Asp Glu Glu Ile Cys Ala Lys Glu Ala Asn Pro Pro Thr Ala Ala Ala 
            180                 185                 190         


Phe Gln Pro Cys Ala Tyr Asn Gln Phe Gln Cys Leu Ser Arg Phe Thr 
        195                 200                 205             


Lys Val Tyr Thr Cys Leu Pro Glu Ser Leu Lys Cys Asp Gly Asn Ile 
    210                 215                 220                 


Asp Cys Leu Asp Leu Gly Asp Glu Ile Asp Cys Asp Val Pro Thr Cys 
225                 230                 235                 240 


Gly Gln Trp Leu Lys Tyr Phe Tyr Gly Thr Phe Asn Ser Pro Asn Tyr 
                245                 250                 255     


Pro Asp Phe Tyr Pro Pro Gly Ser Asn Cys Thr Trp Leu Ile Asp Thr 
            260                 265                 270         


Gly Asp His Arg Lys Val Ile Leu Arg Phe Thr Asp Phe Lys Leu Asp 
        275                 280                 285             


Gly Thr Gly Tyr Gly Asp Tyr Val Lys Ile Tyr Asp Gly Leu Glu Glu 
    290                 295                 300                 


Asn Pro His Lys Leu Leu Arg Val Leu Thr Ala Phe Asp Ser His Ala 
305                 310                 315                 320 


Pro Leu Thr Val Val Ser Ser Ser Gly Gln Ile Arg Val His Phe Cys 
                325                 330                 335     


Ala Asp Lys Val Asn Ala Ala Arg Gly Phe Asn Ala Thr Tyr Gln Val 
            340                 345                 350         


Asp Gly Phe Cys Leu Pro Trp Glu Ile Pro Cys Gly Gly Asn Trp Gly 
        355                 360                 365             


Cys Tyr Thr Glu Gln Gln Arg Cys Asp Gly Tyr Trp His Cys Pro Asn 
    370                 375                 380                 


Gly Arg Asp Glu Thr Asn Cys Thr Met Cys Gln Lys Glu Glu Phe Pro 
385                 390                 395                 400 


Cys Ser Arg Asn Gly Val Cys Tyr Pro Arg Ser Asp Arg Cys Asn Tyr 
                405                 410                 415     


Gln Asn His Cys Pro Asn Gly Ser Asp Glu Lys Asn Cys Phe Phe Cys 
            420                 425                 430         


Gln Pro Gly Asn Phe His Cys Lys Asn Asn Arg Cys Val Phe Glu Ser 
        435                 440                 445             


Trp Val Cys Asp Ser Gln Asp Asp Cys Gly Asp Gly Ser Asp Glu Glu 
    450                 455                 460                 


Asn Cys Pro Val Ile Val Pro Thr Arg Val Ile Thr Ala Ala Val Ile 
465                 470                 475                 480 


Gly Ser Leu Ile Cys Gly Leu Leu Leu Val Ile Ala Leu Gly Cys Thr 
                485                 490                 495     


Cys Lys Leu Tyr Ser Leu Arg Met Phe Glu Arg Arg Ser Phe Glu Thr 
            500                 505                 510         


Gln Leu Ser Arg Val Glu Ala Glu Leu Leu Arg Arg Glu Ala Pro Pro 
        515                 520                 525             


Ser Tyr Gly Gln Leu Ile Ala Gln Gly Leu Ile Pro Pro Val Glu Asp 
    530                 535                 540                 


Phe Pro Val Cys Ser Pro Asn Gln Ala Ser Val Leu Glu Asn Leu Arg 
545                 550                 555                 560 


Leu Ala Val Arg Ser Gln Leu Gly Phe Thr Ser Val Arg Leu Pro Met 
                565                 570                 575     


Ala Gly Arg Ser Ser Asn Ile Trp Asn Arg Ile Phe Asn Phe Ala Arg 
            580                 585                 590         


Ser Arg His Ser Gly Ser Leu Ala Leu Val Ser Ala Asp Gly Asp Glu 
        595                 600                 605             


Val Val Pro Ser Gln Ser Thr Ser Arg Glu Pro Glu Arg Asn His Thr 
    610                 615                 620                 


His Arg Ser Leu Phe Ser Val Glu Ser Asp Asp Thr Asp Thr Glu Asn 
625                 630                 635                 640 


Glu Arg Arg Asp Met Ala Gly Ala Ser Gly Gly Val Ala Ala Pro Leu 
                645                 650                 655     


Pro Gln Lys Val Pro Pro Thr Thr Ala Val Glu Ala Thr Val Gly Ala 
            660                 665                 670         


Cys Ala Ser Ser Ser Thr Gln Ser Thr Arg Gly Gly His Ala Asp Asn 
        675                 680                 685             


Gly Arg Asp Val Thr Ser Val Glu Pro Pro Ser Val Ser Pro Ala Arg 
    690                 695                 700                 


His Gln Leu Thr Ser Ala Leu Ser Arg Met Thr Gln Gly Leu Arg Trp 
705                 710                 715                 720 


Val Arg Phe Thr Leu Gly Arg Ser Ser Ser Leu Ser Gln Asn Gln Ser 
                725                 730                 735     


Pro Leu Arg Gln Leu Asp Asn Gly Val Ser Gly Arg Glu Asp Asp Asp 
            740                 745                 750         


Asp Val Glu Met Leu Ile Pro Ile Ser Asp Gly Ser Ser Asp Phe Asp 
        755                 760                 765             


Val Asn Asp Cys Ser Arg Pro Leu Leu Asp Leu Ala Ser Asp Gln Gly 
    770                 775                 780                 


Gln Gly Leu Arg Gln Pro Tyr Asn Ala Thr Asn Pro Gly Val Arg Pro 
785                 790                 795                 800 


Ser Asn Arg Asp Gly Pro Cys Glu Arg Cys Gly Ile Val His Thr Ala 
                805                 810                 815     


Gln Ile Pro Asp Thr Cys Leu Glu Val Thr Leu Lys Asn Glu Thr Ser 
            820                 825                 830         


Asp Asp Glu Ala Leu Leu Leu Cys 
        835                 840 


<210>  1556
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  1556

Met Gly Thr Glu Lys Glu Ser Pro Glu Pro Asp Cys Gln Lys Gln Phe 
1               5                   10                  15      


Gln Ala Ala Val Ser Val Ile Gln Asn Leu Pro Lys Asn Gly Ser Tyr 
            20                  25                  30          


Arg Pro Ser Tyr Glu Glu Met Leu Arg Phe Tyr Ser Tyr Tyr Lys Gln 
        35                  40                  45              


Ala Thr Met Gly Pro Cys Leu Val Pro Arg Pro Gly Phe Trp Asp Pro 
    50                  55                  60                  


Ile Gly Arg Tyr Lys Trp Asp Ala Trp Asn Ser Leu Gly Lys Met Ser 
65                  70                  75                  80  


Arg Glu Glu Ala Met Ser Ala Tyr Ile Thr Glu Met Lys Leu Val Ala 
                85                  90                  95      


Gln Lys Val Ile Asp Thr Val Pro Leu Gly Glu Val Ala Glu Asp Met 
            100                 105                 110         


Phe Gly Tyr Phe Glu Pro Leu Tyr Gln Val Ile Pro Asp Met Pro Arg 
        115                 120                 125             


Pro Pro Glu Thr Phe Leu Arg Arg Val Thr Gly Trp Lys Glu Gln Val 
    130                 135                 140                 


Val Asn Gly Asp Val Gly Ala Val Ser Glu Pro Pro Cys Leu Pro Lys 
145                 150                 155                 160 


Glu Pro Ala Pro Pro Ser Pro Glu Ser His Ser Pro Arg Asp Leu Asp 
                165                 170                 175     


Ser Glu Val Phe Cys Asp Ser Leu Glu Gln Leu Glu Pro Glu Leu Val 
            180                 185                 190         


Trp Thr Glu Gln Arg Ala Ala Ser Gly Gly Lys Arg Asp Pro Arg Asn 
        195                 200                 205             


Ser Pro Val Pro Pro Thr Lys Lys Glu Gly Leu Arg Gly Ser Pro Pro 
    210                 215                 220                 


Gly Pro Gln Glu Leu Asp Val Trp Leu Leu Gly Thr Val Arg Ala Leu 
225                 230                 235                 240 


Gln Glu Ser Met Gln Glu Val Gln Ala Arg Val Gln Ser Leu Glu Ser 
                245                 250                 255     


Met Pro Arg Pro Pro Glu Gln Arg Pro Gln Pro Arg Pro Ser Ala Arg 
            260                 265                 270         


Pro Trp Pro Leu Gly Leu Pro Gly Pro Ala Leu Leu Phe Phe Leu Leu 
        275                 280                 285             


Trp Pro Phe Val Val Gln Trp Leu Phe Arg Met Phe Arg Thr Gln Lys 
    290                 295                 300                 


Arg 
305 


<210>  1557
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  1557

Met Gly Thr Glu Lys Glu Ser Pro Glu Pro Asp Cys Gln Lys Gln Phe 
1               5                   10                  15      


Gln Ala Ala Val Ser Val Ile Gln Asn Leu Pro Lys Asn Gly Ser Tyr 
            20                  25                  30          


Arg Pro Ser Tyr Glu Glu Met Leu Arg Phe Tyr Ser Tyr Tyr Lys Gln 
        35                  40                  45              


Ala Thr Met Gly Pro Cys Leu Val Pro Arg Pro Gly Phe Trp Asp Pro 
    50                  55                  60                  


Ile Gly Arg Tyr Lys Trp Asp Ala Trp Asn Ser Leu Gly Lys Met Ser 
65                  70                  75                  80  


Arg Glu Glu Ala Met Ser Ala Tyr Ile Thr Glu Met Lys Leu Val Ala 
                85                  90                  95      


Gln Lys Val Ile Asp Thr Val Pro Leu Gly Glu Val Ala Glu Asp Met 
            100                 105                 110         


Phe Gly Tyr Phe Glu Pro Leu Tyr Gln Val Ile Pro Asp Met Pro Arg 
        115                 120                 125             


Pro Pro Glu Thr Phe Leu Arg Arg Val Thr Gly Trp Lys Glu Gln Val 
    130                 135                 140                 


Val Asn Gly Asp Val Gly Ala Val Ser Glu Pro Pro Cys Leu Pro Lys 
145                 150                 155                 160 


Glu Pro Ala Pro Pro Ser Pro Glu Ser His Ser Pro Arg Asp Leu Asp 
                165                 170                 175     


Ser Glu Val Phe Cys Asp Ser Leu Glu Gln Leu Glu Pro Glu Leu Val 
            180                 185                 190         


Trp Thr Glu Gln Arg Ala Ala Ser Gly Gly Lys Arg Asp Pro Arg Asn 
        195                 200                 205             


Ser Pro Val Pro Pro Thr Lys Lys Glu Gly Leu Arg Gly Ser Pro Pro 
    210                 215                 220                 


Gly Pro Gln Glu Leu Asp Val Trp Leu Leu Gly Thr Val Arg Ala Leu 
225                 230                 235                 240 


Gln Glu Ser Met Gln Glu Val Gln Ala Arg Val Gln Ser Leu Glu Ser 
                245                 250                 255     


Met Pro Arg Pro Pro Glu Gln Arg Pro Gln Pro Arg Pro Ser Ala Arg 
            260                 265                 270         


Pro Trp Pro Leu Gly Leu Pro Gly Pro Ala Leu Leu Phe Phe Leu Leu 
        275                 280                 285             


Trp Pro Phe Val Val Gln Trp Leu Phe Arg Met Phe Arg Thr Gln Lys 
    290                 295                 300                 


Arg 
305 


<210>  1558
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  1558

Met Gly Thr Glu Lys Glu Ser Pro Glu Pro Asp Cys Gln Lys Gln Phe 
1               5                   10                  15      


Gln Ala Ala Val Ser Val Ile Gln Asn Leu Pro Lys Asn Gly Ser Tyr 
            20                  25                  30          


Arg Pro Ser Tyr Glu Glu Met Leu Arg Phe Tyr Ser Tyr Tyr Lys Gln 
        35                  40                  45              


Ala Thr Met Gly Pro Cys Leu Val Pro Arg Pro Gly Phe Trp Asp Pro 
    50                  55                  60                  


Ile Gly Arg Tyr Lys Trp Asp Ala Trp Asn Ser Leu Gly Lys Met Ser 
65                  70                  75                  80  


Arg Glu Glu Ala Met Ser Ala Tyr Ile Thr Glu Met Lys Leu Val Ala 
                85                  90                  95      


Gln Lys Val Ile Asp Thr Val Pro Leu Gly Glu Val Ala Glu Asp Met 
            100                 105                 110         


Phe Gly Tyr Phe Glu Pro Leu Tyr Gln Val Ile Pro Asp Met Pro Arg 
        115                 120                 125             


Pro Pro Glu Thr Phe Leu Arg Arg Val Thr Gly Trp Lys Glu Gln Val 
    130                 135                 140                 


Val Asn Gly Asp Val Gly Ala Val Ser Glu Pro Pro Cys Leu Pro Lys 
145                 150                 155                 160 


Glu Pro Ala Pro Pro Ser Pro Ala Ser Leu Trp Ala Val Thr Leu Pro 
                165                 170                 175     


Thr Pro Pro Gln Ser Pro Ile His Pro Gly Thr Trp Thr Pro Arg Phe 
            180                 185                 190         


Ser Val Ile Pro Trp Ser Ser Trp Ser Leu Ser Trp Phe Gly Gln Ser 
        195                 200                 205             


Ser Gly Gln His Leu Glu Glu Ser Val Ile Pro Gly Thr Ala Pro Cys 
    210                 215                 220                 


Pro Pro Gln Arg Lys Arg Gly Cys Gly Ala Ala Arg Arg Gly Pro Arg 
225                 230                 235                 240 


Ser Trp Thr Cys Gly Cys Trp Gly Gln Phe Glu His Tyr Arg Arg Ala 
                245                 250                 255     


Cys Arg Arg Cys Arg Arg Gly Cys Arg Ala Trp Arg Ala Cys Pro Gly 
            260                 265                 270         


Pro Leu Ser Arg Gly Arg Ser Pro Gly Pro Val Leu Gly His Gly Pro 
        275                 280                 285             


Leu Gly Ser Arg Gly Pro Arg Cys Ser Ser Ser Ser Cys Gly Pro Ser 
    290                 295                 300                 


Ser Ser Ser Gly Ser Ser Glu Cys Phe Gly Pro Lys Arg Gly Asp Cys 
305                 310                 315                 320 


Gln Trp Arg Gly Leu Cys Ser Gln Leu Arg Leu Ser Cys Cys Ala Leu 
                325                 330                 335     


Ser Leu Pro Arg Val 
            340     


<210>  1559
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  1559

Met Gly Thr Glu Lys Glu Ser Pro Glu Pro Asp Cys Gln Lys Gln Phe 
1               5                   10                  15      


Gln Ala Ala Val Ser Val Ile Gln Asn Leu Pro Lys Asn Gly Ser Tyr 
            20                  25                  30          


Arg Pro Ser Tyr Glu Glu Met Leu Arg Phe Tyr Ser Tyr Tyr Lys Gln 
        35                  40                  45              


Ala Thr Met Gly Pro Cys Leu Val Pro Arg Pro Gly Phe Trp Asp Pro 
    50                  55                  60                  


Ile Gly Arg Tyr Lys Trp Asp Ala Trp Asn Ser Leu Gly Lys Met Ser 
65                  70                  75                  80  


Arg Glu Glu Ala Met Ser Ala Tyr Ile Thr Glu Met Lys Leu Val Ala 
                85                  90                  95      


Gln Lys Val Ile Asp Thr Val Pro Leu Gly Glu Val Ala Glu Asp Met 
            100                 105                 110         


Phe Gly Tyr Phe Glu Pro Leu Tyr Gln Val Ile Pro Asp Met Pro Arg 
        115                 120                 125             


Pro Pro Glu Thr Phe Leu Arg Arg Val Thr Gly Trp Lys Glu Gln Val 
    130                 135                 140                 


Val Asn Gly Asp Val Gly Ala Val Ser Glu Pro Pro Cys Leu Pro Lys 
145                 150                 155                 160 


Glu Pro Ala Pro Pro Ser Pro Glu Ser His Ser Pro Arg Asp Leu Asp 
                165                 170                 175     


Ser Glu Val Phe Cys Asp Ser Leu Glu Gln Leu Glu Pro Glu Leu Ser 
            180                 185                 190         


Ser Gly Gln His Leu Glu Glu Ser Val Ile Pro Gly Thr Ala Pro Cys 
        195                 200                 205             


Pro Pro Gln Arg Lys Arg Gly Cys Gly Ala Ala Arg Arg Gly Pro Arg 
    210                 215                 220                 


Ser Trp Thr Cys Gly Cys Trp Gly Gln Phe Glu His Tyr Arg Arg Ala 
225                 230                 235                 240 


Cys Arg Arg Cys Arg Arg Gly Cys Arg Ala Trp Arg Ala Cys Pro Gly 
                245                 250                 255     


Pro Leu Ser Ser Leu Thr Leu Ser Val Arg Leu Glu 
            260                 265             


<210>  1560
<211>  973
<212>  PRT
<213>  Homo sapiens

<400>  1560

Met Asp Pro Phe Arg Pro Ser Phe Arg Gly Gln Ser Pro Ile His Pro 
1               5                   10                  15      


Ser Gln Cys Gln Ala Val Arg Met Pro Gly Cys Trp Pro Gln Ala Ser 
            20                  25                  30          


Lys Pro Leu Asp Pro Ala Leu Gly Arg Gly Ala Pro Ala Gly Arg Gly 
        35                  40                  45              


His Val Phe Gly Lys Pro Glu Glu Pro Ser Thr Gln Arg Gly Pro Ala 
    50                  55                  60                  


Gln Arg Glu Ser Val Gly Leu Val Ser Met Phe Arg Gly Leu Gly Ile 
65                  70                  75                  80  


Glu Thr Val Ser Lys Thr Pro Leu Lys Arg Glu Met Leu Pro Ser Gly 
                85                  90                  95      


Arg Gly Ile Leu Gly Arg Gly Leu Ser Ala Asn Leu Val Arg Lys Asp 
            100                 105                 110         


Arg Glu Glu Leu Ser Pro Thr Phe Trp Asp Pro Lys Val Leu Ala Ala 
        115                 120                 125             


Gly Asp Ser Lys Met Ala Glu Thr Ser Val Gly Trp Ser Arg Thr Leu 
    130                 135                 140                 


Gly Arg Gly Ser Ser Asp Ala Ser Leu Leu Pro Leu Gly Arg Ala Ala 
145                 150                 155                 160 


Gly Gly Ile Ser Arg Glu Val Asp Lys Pro Pro Cys Thr Phe Ser Thr 
                165                 170                 175     


Pro Ser Arg Gly Pro Pro Gln Leu Ser Ser Pro Pro Ala Leu Pro Gln 
            180                 185                 190         


Ser Pro Leu His Ser Pro Asp Arg Pro Leu Val Leu Thr Val Glu His 
        195                 200                 205             


Lys Glu Lys Glu Leu Ile Val Lys Gln Gly Ser Lys Gly Thr Pro Gln 
    210                 215                 220                 


Ser Leu Gly Leu Asn Leu Val Lys Ile Gln Cys His Asn Glu Ala Val 
225                 230                 235                 240 


Tyr Gln Tyr His Val Thr Phe Ser Pro Asn Val Glu Cys Lys Ser Met 
                245                 250                 255     


Arg Phe Gly Met Leu Lys Asp His Gln Ala Val Thr Gly Asn Val Thr 
            260                 265                 270         


Ala Phe Asp Gly Ser Ile Leu Tyr Leu Pro Val Lys Leu Gln Gln Val 
        275                 280                 285             


Leu Glu Leu Lys Ser Gln Arg Lys Thr Asp Ser Ala Glu Ile Ser Ile 
    290                 295                 300                 


Lys Ile Gln Met Thr Lys Ile Leu Glu Pro Cys Ser Asp Leu Cys Ile 
305                 310                 315                 320 


Pro Phe Tyr Asn Val Val Phe Arg Arg Val Met Lys Leu Leu Asp Met 
                325                 330                 335     


Lys Leu Val Gly Arg Asn Phe Tyr Asp Pro Thr Ser Ala Met Val Leu 
            340                 345                 350         


Gln Gln His Arg Leu Gln Ile Trp Pro Gly Tyr Ala Ala Ser Ile Arg 
        355                 360                 365             


Arg Thr Asp Gly Gly Leu Phe Leu Leu Ala Asp Val Ser His Lys Val 
    370                 375                 380                 


Ile Arg Asn Asp Cys Val Leu Asp Val Met His Ala Ile Tyr Gln Gln 
385                 390                 395                 400 


Asn Lys Glu His Phe Gln Asp Glu Cys Thr Lys Leu Leu Val Gly Asn 
                405                 410                 415     


Ile Val Ile Thr Arg Tyr Asn Asn Arg Thr Tyr Arg Ile Asp Asp Val 
            420                 425                 430         


Asp Trp Asn Lys Thr Pro Lys Asp Ser Phe Thr Met Ser Asp Gly Lys 
        435                 440                 445             


Glu Ile Thr Phe Leu Glu Tyr Tyr Ser Lys Asn Tyr Gly Ile Thr Val 
    450                 455                 460                 


Lys Glu Glu Asp Gln Pro Leu Leu Ile His Arg Pro Ser Glu Arg Gln 
465                 470                 475                 480 


Asp Asn His Gly Met Leu Leu Lys Gly Glu Ile Leu Leu Leu Pro Glu 
                485                 490                 495     


Leu Ser Phe Met Thr Gly Ile Pro Glu Lys Met Lys Lys Asp Phe Arg 
            500                 505                 510         


Ala Met Lys Asp Leu Ala Gln Gln Ile Asn Leu Ser Pro Lys Gln His 
        515                 520                 525             


His Ser Ala Leu Glu Cys Leu Leu Gln Arg Ile Ala Lys Asn Glu Ala 
    530                 535                 540                 


Ala Thr Asn Glu Leu Met Arg Trp Gly Leu Arg Leu Gln Lys Asp Val 
545                 550                 555                 560 


His Lys Ile Glu Gly Arg Val Leu Pro Met Glu Arg Ile Asn Leu Lys 
                565                 570                 575     


Asn Thr Ser Phe Ile Thr Ser Gln Glu Leu Asn Trp Val Lys Glu Val 
            580                 585                 590         


Thr Arg Asp Pro Ser Ile Leu Thr Ile Pro Met His Phe Trp Ala Leu 
        595                 600                 605             


Phe Tyr Pro Lys Arg Ala Met Asp Gln Ala Arg Glu Leu Val Asn Met 
    610                 615                 620                 


Leu Glu Lys Ile Ala Gly Pro Ile Gly Met Arg Met Ser Pro Pro Ala 
625                 630                 635                 640 


Trp Val Glu Leu Lys Asp Asp Arg Ile Glu Thr Tyr Val Arg Thr Ile 
                645                 650                 655     


Gln Ser Thr Leu Gly Ala Glu Gly Lys Ile Gln Met Val Val Cys Ile 
            660                 665                 670         


Ile Met Gly Pro Arg Asp Asp Leu Tyr Gly Ala Ile Lys Lys Leu Cys 
        675                 680                 685             


Cys Val Gln Ser Pro Val Pro Ser Gln Val Val Asn Val Arg Thr Ile 
    690                 695                 700                 


Gly Gln Pro Thr Arg Leu Arg Ser Val Ala Gln Lys Ile Leu Leu Gln 
705                 710                 715                 720 


Ile Asn Cys Lys Leu Gly Gly Glu Leu Trp Gly Val Asp Ile Pro Leu 
                725                 730                 735     


Lys Gln Leu Met Val Ile Gly Met Asp Val Tyr His Asp Pro Ser Arg 
            740                 745                 750         


Gly Met Arg Ser Val Val Gly Phe Val Ala Ser Ile Asn Leu Thr Leu 
        755                 760                 765             


Thr Lys Trp Tyr Ser Arg Val Val Phe Gln Met Pro His Gln Glu Ile 
    770                 775                 780                 


Val Asp Ser Leu Lys Leu Cys Leu Val Gly Ser Leu Lys Lys Phe Tyr 
785                 790                 795                 800 


Glu Val Asn His Cys Leu Pro Glu Lys Ile Val Val Tyr Arg Asp Gly 
                805                 810                 815     


Val Ser Asp Gly Gln Leu Lys Thr Val Ala Asn Tyr Glu Ile Pro Gln 
            820                 825                 830         


Leu Gln Lys Cys Phe Glu Ala Phe Glu Asn Tyr Gln Pro Lys Met Val 
        835                 840                 845             


Val Phe Val Val Gln Lys Lys Ile Ser Thr Asn Leu Tyr Leu Ala Ala 
    850                 855                 860                 


Pro Gln Asn Phe Val Thr Pro Thr Pro Gly Thr Val Val Asp His Thr 
865                 870                 875                 880 


Ile Thr Ser Cys Glu Trp Val Asp Phe Tyr Leu Leu Ala His His Val 
                885                 890                 895     


Arg Gln Gly Cys Gly Ile Pro Thr His Tyr Val Cys Val Leu Asn Thr 
            900                 905                 910         


Ala Asn Leu Ser Pro Asp His Met Gln Arg Leu Thr Phe Lys Leu Cys 
        915                 920                 925             


His Met Tyr Trp Asn Trp Pro Gly Thr Ile Arg Val Pro Ala Pro Cys 
    930                 935                 940                 


Lys Tyr Ala His Lys Leu Ala Phe Leu Ser Gly His Ile Leu His His 
945                 950                 955                 960 


Glu Pro Ala Ile Gln Leu Cys Glu Asn Leu Phe Phe Leu 
                965                 970             


<210>  1561
<211>  997
<212>  PRT
<213>  Homo sapiens

<400>  1561

Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 
1               5                   10                  15      


Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
            20                  25                  30          


Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              


Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 
            180                 185                 190         


Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val 
    210                 215                 220                 


Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val 
225                 230                 235                 240 


Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
            260                 265                 270         


Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             


Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile 
        355                 360                 365             


Leu Asp Arg Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Thr Ile 
    370                 375                 380                 


Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val His Lys Asp Asp Lys 
385                 390                 395                 400 


Pro Val Asn Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys 
    450                 455                 460                 


Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe 
            500                 505                 510         


Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 
        515                 520                 525             


Val Gly Ser Thr Lys Val Pro Met Thr Ser Gly Val Lys Gln Lys Ile 
    530                 535                 540                 


Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 
545                 550                 555                 560 


Leu Ala Leu Ala Thr His Asp Asn Pro Leu Arg Arg Glu Glu Met His 
                565                 570                 575     


Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe 
            580                 585                 590         


Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser 
        595                 600                 605             


Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr 
    610                 615                 620                 


Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 
625                 630                 635                 640 


Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 
                645                 650                 655     


Phe Asp Glu Leu Asn Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 
            660                 665                 670         


Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 
        675                 680                 685             


Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val 
    690                 695                 700                 


Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly 
705                 710                 715                 720 


Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp 
                725                 730                 735     


Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 
            740                 745                 750         


Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 
        755                 760                 765             


Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 
    770                 775                 780                 


Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 
785                 790                 795                 800 


Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 
                805                 810                 815     


Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu 
            820                 825                 830         


Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val 
        835                 840                 845             


Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 
    850                 855                 860                 


Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro 
865                 870                 875                 880 


Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met 
                885                 890                 895     


Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 
            900                 905                 910         


Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 
        915                 920                 925             


Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 
    930                 935                 940                 


Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro 
945                 950                 955                 960 


Leu Asn Val Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 
                965                 970                 975     


Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 
            980                 985                 990         


Pro Ala Ile Leu Glu 
        995         


<210>  1562
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  1562

Met Ala Arg Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu 
1               5                   10                  15      


Leu Val Leu Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln 
            20                  25                  30          


Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro 
        35                  40                  45              


Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu 
    50                  55                  60                  


Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln 
65                  70                  75                  80  


Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala 
                85                  90                  95      


Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly 
            100                 105                 110         


Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe 
        115                 120                 125             


Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys 
    130                 135                 140                 


Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro 
145                 150                 155                 160 


Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln 
                165                 170                 175     


Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val 
            180                 185                 190         


Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu 
        195                 200                 205             


Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu 
    210                 215                 220                 


His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val 
225                 230                 235                 240 


Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr 
                245                 250                 255     


Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro 
            260                 265                 270         


Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro 
        275                 280                 285             


Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys 
    290                 295                 300                 


Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala 
305                 310                 315                 320 


Arg Gln Ala Glu Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu 
                325                 330                 335     


His Ser Gly Thr Glu His Ala Ser Ala Ser Ala Asn Gly His Val Ser 
            340                 345                 350         


Tyr Ser Ala Val Ser Arg Glu Asn Ser Ser Ser Gln Asp Pro Gln Thr 
        355                 360                 365             


Glu Gly Thr Arg 
    370         


<210>  1563
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  1563

Met Ala Arg Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu 
1               5                   10                  15      


Leu Val Leu Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln 
            20                  25                  30          


Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro 
        35                  40                  45              


Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu 
    50                  55                  60                  


Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln 
65                  70                  75                  80  


Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala 
                85                  90                  95      


Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly 
            100                 105                 110         


Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe 
        115                 120                 125             


Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys 
    130                 135                 140                 


Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro 
145                 150                 155                 160 


Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln 
                165                 170                 175     


Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val 
            180                 185                 190         


Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu 
        195                 200                 205             


Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu 
    210                 215                 220                 


His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val 
225                 230                 235                 240 


Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr 
                245                 250                 255     


Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro 
            260                 265                 270         


Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro 
        275                 280                 285             


Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys 
    290                 295                 300                 


Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala 
305                 310                 315                 320 


Arg Gln Ala Glu Leu Thr Val Gln Val Lys Gly Thr Glu His Ala Ser 
                325                 330                 335     


Ala Ser Ala Asn Gly His Val Ser Tyr Ser Ala Val Ser Arg Glu Asn 
            340                 345                 350         


Ser Ser Ser Gln Asp Pro Gln Thr Glu Gly Thr Arg 
        355                 360                 


<210>  1564
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  1564

Met Ala Arg Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu 
1               5                   10                  15      


Leu Val Leu Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln 
            20                  25                  30          


Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro 
        35                  40                  45              


Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu 
    50                  55                  60                  


Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln 
65                  70                  75                  80  


Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala 
                85                  90                  95      


Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly 
            100                 105                 110         


Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe 
        115                 120                 125             


Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys 
    130                 135                 140                 


Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro 
145                 150                 155                 160 


Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln 
                165                 170                 175     


Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val 
            180                 185                 190         


Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu 
        195                 200                 205             


Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu 
    210                 215                 220                 


His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val 
225                 230                 235                 240 


Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr 
                245                 250                 255     


Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro 
            260                 265                 270         


Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro 
        275                 280                 285             


Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys 
    290                 295                 300                 


Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala 
305                 310                 315                 320 


Arg Gln Ala Glu Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu 
                325                 330                 335     


His Ser Gly Met Ser Arg Asn Ala Ile Ile Phe Leu Val Leu Gly Ile 
            340                 345                 350         


Leu Val Phe Leu Ile Leu Leu Gly Ile Gly Ile Tyr Phe Tyr Trp Ser 
        355                 360                 365             


Lys Cys Ser Arg Glu Val Leu Trp His Cys His Leu Cys Pro Ser Ser 
    370                 375                 380                 


Glu His His Gln Ser Cys Arg Asn 
385                 390         


<210>  1565
<211>  615
<212>  PRT
<213>  Homo sapiens

<400>  1565

Met Ala Pro Pro Gly Ser Ser Thr Val Phe Leu Leu Ala Leu Thr Ile 
1               5                   10                  15      


Ile Ala Ser Thr Trp Ala Leu Thr Pro Thr His Tyr Leu Thr Lys His 
            20                  25                  30          


Asp Val Glu Arg Leu Lys Ala Ser Leu Asp Arg Pro Phe Thr Asn Leu 
        35                  40                  45              


Glu Ser Ala Phe Tyr Ser Ile Val Gly Leu Ser Ser Leu Gly Ala Gln 
    50                  55                  60                  


Val Pro Asp Ala Lys Ile Ser Ile Ser Asn Glu Thr Lys Asp Leu Leu 
65                  70                  75                  80  


Leu Ala Ala Val Ser Glu Asp Ser Ser Val Thr Gln Ile Tyr His Ala 
                85                  90                  95      


Val Ala Ala Leu Ser Gly Phe Gly Leu Pro Leu Ala Ser Gln Glu Ala 
            100                 105                 110         


Leu Ser Ala Leu Thr Ala Arg Leu Ser Lys Glu Glu Thr Val Leu Ala 
        115                 120                 125             


Thr Val Gln Ala Leu Gln Thr Ala Ser His Leu Ser Gln Gln Ala Asp 
    130                 135                 140                 


Leu Arg Ser Ile Val Glu Glu Ile Glu Asp Leu Val Ala Arg Leu Asp 
145                 150                 155                 160 


Glu Leu Gly Gly Val Tyr Leu Gln Phe Glu Glu Gly Leu Glu Thr Thr 
                165                 170                 175     


Ala Leu Phe Val Ala Ala Thr Tyr Lys Leu Met Asp His Val Gly Thr 
            180                 185                 190         


Glu Pro Ser Ile Lys Glu Asp Gln Val Ile Gln Leu Met Asn Ala Ile 
        195                 200                 205             


Phe Ser Lys Lys Asn Phe Glu Ser Leu Ser Glu Ala Phe Ser Val Ala 
    210                 215                 220                 


Ser Ala Ala Ala Val Leu Ser His Asn Arg Tyr His Val Pro Val Val 
225                 230                 235                 240 


Val Val Pro Glu Gly Ser Ala Ser Asp Thr His Glu Gln Ala Ile Leu 
                245                 250                 255     


Arg Leu Gln Val Thr Asn Val Leu Ser Gln Pro Leu Thr Gln Ala Thr 
            260                 265                 270         


Val Lys Leu Glu His Ala Lys Ser Val Ala Ser Arg Ala Thr Val Leu 
        275                 280                 285             


Gln Lys Thr Ser Phe Thr Pro Val Gly Asp Val Phe Glu Leu Asn Phe 
    290                 295                 300                 


Met Asn Val Lys Phe Ser Ser Gly Tyr Tyr Asp Phe Leu Val Glu Val 
305                 310                 315                 320 


Glu Gly Asp Asn Arg Tyr Ile Ala Asn Thr Val Glu Leu Arg Val Lys 
                325                 330                 335     


Ile Ser Thr Glu Val Gly Ile Thr Asn Val Asp Leu Ser Thr Val Asp 
            340                 345                 350         


Lys Asp Gln Ser Ile Ala Pro Lys Thr Thr Arg Val Thr Tyr Pro Ala 
        355                 360                 365             


Lys Ala Lys Gly Thr Phe Ile Ala Asp Ser His Gln Asn Phe Ala Leu 
    370                 375                 380                 


Phe Phe Gln Leu Val Asp Val Asn Thr Gly Ala Glu Leu Thr Pro His 
385                 390                 395                 400 


Gln Thr Phe Val Arg Leu His Asn Gln Lys Thr Gly Gln Glu Val Val 
                405                 410                 415     


Phe Val Ala Glu Pro Asp Asn Lys Asn Val Tyr Lys Phe Glu Leu Asp 
            420                 425                 430         


Thr Ser Glu Arg Lys Ile Glu Phe Asp Ser Ala Ser Gly Thr Tyr Thr 
        435                 440                 445             


Leu Tyr Leu Ile Ile Gly Asp Ala Thr Leu Lys Asn Pro Ile Leu Trp 
    450                 455                 460                 


Asn Val Ala Asp Val Val Ile Lys Phe Pro Glu Glu Glu Ala Pro Ser 
465                 470                 475                 480 


Thr Val Leu Ser Gln Asn Leu Phe Thr Pro Lys Gln Glu Ile Gln His 
                485                 490                 495     


Leu Phe Arg Glu Pro Glu Lys Arg Pro Pro Thr Val Val Ser Asn Thr 
            500                 505                 510         


Phe Thr Ala Leu Ile Leu Ser Pro Leu Leu Leu Leu Phe Ala Leu Trp 
        515                 520                 525             


Ile Arg Ile Gly Ala Asn Val Ser Asn Phe Thr Phe Ala Pro Ser Thr 
    530                 535                 540                 


Ile Ile Phe His Leu Gly His Ala Ala Met Leu Gly Leu Met Tyr Val 
545                 550                 555                 560 


Tyr Trp Thr Gln Leu Asn Met Phe Gln Thr Leu Lys Tyr Leu Ala Ile 
                565                 570                 575     


Leu Gly Ser Val Thr Phe Leu Ala Gly Asn Arg Met Leu Ala Gln Gln 
            580                 585                 590         


Ala Val Lys Arg Ile Ala Ala Glu Gln Ser Ser Arg Leu Ala Lys Tyr 
        595                 600                 605             


Arg Thr Leu Arg Thr Ala His 
    610                 615 


<210>  1566
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  1566

Met Ser Ser Ser Gly Gly Ala Pro Gly Ala Ser Ala Ser Ser Ala Pro 
1               5                   10                  15      


Pro Ala Gln Glu Glu Gly Met Thr Trp Trp Tyr Arg Trp Leu Cys Arg 
            20                  25                  30          


Leu Ser Gly Val Leu Gly Ala Val Ser Cys Ala Ile Ser Gly Leu Phe 
        35                  40                  45              


Asn Cys Ile Thr Ile His Pro Leu Asn Ile Ala Ala Gly Val Trp Met 
    50                  55                  60                  


Met Met Ala Val Val Pro Ile Val Ile Ser Leu Thr Leu Thr Thr Leu 
65                  70                  75                  80  


Leu Gly Asn Ala Ile Ala Phe Ala Thr Gly Val Leu Tyr Gly Leu Ser 
                85                  90                  95      


Ala Leu Gly Lys Lys Gly Asp Ala Ile Ser Tyr Ala Arg Ile Gln Gln 
            100                 105                 110         


Gln Arg Gln Gln Ala Asp Glu Glu Lys Leu Ala Glu Thr Leu Glu Gly 
        115                 120                 125             


Glu Leu 
    130 


<210>  1567
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  1567

Met Val Ser Glu Ser His His Glu Ala Leu Ala Ala Pro Pro Val Thr 
1               5                   10                  15      


Thr Val Ala Thr Val Leu Pro Ser Asn Ala Thr Glu Pro Ala Ser Pro 
            20                  25                  30          


Gly Glu Gly Lys Glu Asp Ala Phe Ser Lys Leu Lys Glu Lys Phe Met 
        35                  40                  45              


Asn Glu Leu His Lys Ile Pro Leu Pro Pro Trp Ala Leu Ile Ala Ile 
    50                  55                  60                  


Ala Ile Val Ala Val Leu Leu Val Leu Thr Cys Cys Phe Cys Ile Cys 
65                  70                  75                  80  


Lys Lys Cys Leu Phe Lys Lys Lys Asn Lys Lys Lys Gly Lys Glu Lys 
                85                  90                  95      


Gly Gly Lys Asn Ala Ile Asn Met Lys Asp Val Lys Asp Leu Gly Lys 
            100                 105                 110         


Thr Met Lys Asp Gln Ala Leu Lys Asp Asp Asp Ala Glu Thr Gly Leu 
        115                 120                 125             


Thr Asp Gly Glu Glu Lys Glu Glu Pro Lys Glu Glu Glu Lys Leu Gly 
    130                 135                 140                 


Lys Leu Gln Tyr Ser Leu Asp Tyr Asp Phe Gln Asn Asn Gln Leu Leu 
145                 150                 155                 160 


Val Gly Ile Ile Gln Ala Ala Glu Leu Pro Ala Leu Asp Met Gly Gly 
                165                 170                 175     


Thr Ser Asp Pro Tyr Val Lys Val Phe Leu Leu Pro Asp Lys Lys Lys 
            180                 185                 190         


Lys Phe Glu Thr Lys Val His Arg Lys Thr Leu Asn Pro Val Phe Asn 
        195                 200                 205             


Glu Gln Phe Thr Phe Lys Val Pro Tyr Ser Glu Leu Gly Gly Lys Thr 
    210                 215                 220                 


Leu Val Met Ala Val Tyr Asp Phe Asp Arg Phe Ser Lys His Asp Ile 
225                 230                 235                 240 


Ile Gly Glu Phe Lys Val Pro Met Asn Thr Val Asp Phe Gly His Val 
                245                 250                 255     


Thr Glu Glu Trp Arg Asp Leu Gln Ser Ala Glu Lys Glu Glu Gln Glu 
            260                 265                 270         


Lys Leu Gly Asp Ile Cys Phe Ser Leu Arg Tyr Val Pro Thr Ala Gly 
        275                 280                 285             


Lys Leu Thr Val Val Ile Leu Glu Ala Lys Asn Leu Lys Lys Met Asp 
    290                 295                 300                 


Val Gly Gly Leu Ser Asp Pro Tyr Val Lys Ile His Leu Met Gln Asn 
305                 310                 315                 320 


Gly Lys Arg Leu Lys Lys Lys Lys Thr Thr Ile Lys Lys Asn Thr Leu 
                325                 330                 335     


Asn Pro Tyr Tyr Asn Glu Ser Phe Ser Phe Glu Val Pro Phe Glu Gln 
            340                 345                 350         


Ile Gln Lys Val Gln Val Val Val Thr Val Leu Asp Tyr Asp Lys Ile 
        355                 360                 365             


Gly Lys Asn Asp Ala Ile Gly Lys Val Phe Val Gly Tyr Asn Ser Thr 
    370                 375                 380                 


Gly Ala Glu Leu Arg His Trp Ser Asp Met Leu Ala Asn Pro Arg Arg 
385                 390                 395                 400 


Pro Ile Ala Gln Trp His Thr Leu Gln Val Glu Glu Glu Val Asp Ala 
                405                 410                 415     


Met Leu Ala Val Lys Lys 
            420         


<210>  1568
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  1568

Met Val Ser Glu Ser His His Glu Ala Leu Ala Ala Pro Pro Val Thr 
1               5                   10                  15      


Thr Val Ala Thr Val Leu Pro Ser Asn Ala Thr Glu Pro Ala Ser Pro 
            20                  25                  30          


Gly Glu Gly Lys Glu Asp Ala Phe Ser Lys Leu Lys Glu Lys Phe Met 
        35                  40                  45              


Asn Glu Leu His Lys Ile Pro Leu Pro Pro Trp Ala Leu Ile Ala Ile 
    50                  55                  60                  


Ala Ile Val Ala Val Leu Leu Val Leu Thr Cys Cys Phe Cys Ile Cys 
65                  70                  75                  80  


Lys Lys Cys Leu Phe Lys Lys Lys Asn Lys Lys Lys Gly Lys Glu Lys 
                85                  90                  95      


Gly Gly Lys Asn Ala Ile Asn Met Lys Asp Val Lys Asp Leu Gly Lys 
            100                 105                 110         


Thr Met Lys Asp Gln Ala Leu Lys Asp Asp Asp Ala Glu Thr Gly Leu 
        115                 120                 125             


Thr Asp Gly Glu Glu Lys Glu Glu Pro Lys Glu Glu Glu Lys Leu Gly 
    130                 135                 140                 


Lys Leu Gln Tyr Ser Leu Asp Tyr Asp Phe Gln Asn Asn Gln Leu Leu 
145                 150                 155                 160 


Val Gly Ile Ile Gln Ala Ala Glu Leu Pro Ala Leu Asp Met Gly Gly 
                165                 170                 175     


Thr Ser Asp Pro Tyr Val Lys Val Phe Leu Leu Pro Asp Lys Lys Lys 
            180                 185                 190         


Lys Phe Glu Thr Lys Val His Arg Lys Thr Leu Asn Pro Val Phe Asn 
        195                 200                 205             


Glu Gln Phe Thr Phe Lys Val Pro Tyr Ser Glu Leu Gly Gly Lys Thr 
    210                 215                 220                 


Leu Val Met Ala Val Tyr Asp Phe Asp Arg Phe Ser Lys His Asp Ile 
225                 230                 235                 240 


Ile Gly Glu Phe Lys Val Pro Met Asn Thr Val Asp Phe Gly His Val 
                245                 250                 255     


Thr Glu Glu Trp Arg Asp Leu Gln Ser Ala Glu Lys Glu Glu Gln Glu 
            260                 265                 270         


Lys Leu Gly Asp Ile Cys Phe Ser Leu Arg Tyr Val Pro Thr Ala Gly 
        275                 280                 285             


Lys Leu Thr Val Val Ile Leu Glu Ala Lys Asn Leu Lys Lys Met Asp 
    290                 295                 300                 


Val Gly Gly Leu Ser Asp Pro Tyr Val Lys Ile His Leu Met Gln Asn 
305                 310                 315                 320 


Gly Lys Arg Leu Lys Lys Lys Lys Thr Thr Ile Lys Lys Asn Thr Leu 
                325                 330                 335     


Asn Pro Tyr Tyr Asn Glu Ser Phe Ser Phe Glu Val Pro Phe Glu Gln 
            340                 345                 350         


Ile Gln Lys Val Gln Val Val Val Thr Val Leu Asp Tyr Asp Lys Ile 
        355                 360                 365             


Gly Lys Asn Asp Ala Ile Gly Lys Val Phe Val Gly Tyr Asn Ser Thr 
    370                 375                 380                 


Gly Ala Glu Leu Arg His Trp Ser Asp Met Leu Ala Asn Pro Arg Arg 
385                 390                 395                 400 


Pro Ile Ala Gln Trp His Thr Leu Gln Val Glu Glu Glu Val Asp Ala 
                405                 410                 415     


Met Leu Ala Val Lys Lys 
            420         


<210>  1569
<211>  1320
<212>  PRT
<213>  Homo sapiens

<400>  1569

Met Tyr Ala Thr Asp Ser Arg Gly His Ser Pro Ala Phe Leu Gln Pro 
1               5                   10                  15      


Gln Asn Gly Asn Ser Arg His Pro Ser Gly Tyr Val Pro Gly Lys Val 
            20                  25                  30          


Val Pro Leu Arg Pro Pro Pro Pro Pro Lys Ser Gln Ala Ser Ala Lys 
        35                  40                  45              


Phe Thr Ser Ile Arg Arg Glu Asp Arg Ala Thr Phe Ala Phe Ser Pro 
    50                  55                  60                  


Glu Glu Gln Gln Ala Gln Arg Glu Ser Gln Lys Gln Lys Arg His Lys 
65                  70                  75                  80  


Asn Thr Phe Ile Cys Phe Ala Ile Thr Ser Phe Ser Phe Phe Ile Ala 
                85                  90                  95      


Leu Ala Ile Ile Leu Gly Ile Ser Ser Lys Tyr Ala Pro Asp Glu Asn 
            100                 105                 110         


Cys Pro Asp Gln Asn Pro Arg Leu Arg Asn Trp Asp Pro Gly Gln Asp 
        115                 120                 125             


Ser Ala Lys Gln Val Val Ile Lys Glu Gly Asp Met Leu Arg Leu Thr 
    130                 135                 140                 


Ser Asp Ala Thr Val His Ser Ile Val Ile Gln Asp Gly Gly Leu Leu 
145                 150                 155                 160 


Val Phe Gly Asp Asn Lys Asp Gly Ser Arg Asn Ile Thr Leu Arg Thr 
                165                 170                 175     


His Tyr Ile Leu Ile Gln Asp Gly Gly Ala Leu His Ile Gly Ala Glu 
            180                 185                 190         


Lys Cys Arg Tyr Lys Ser Lys Ala Thr Ile Thr Leu Tyr Gly Lys Ser 
        195                 200                 205             


Asp Glu Gly Glu Ser Met Pro Thr Phe Gly Lys Lys Phe Ile Gly Val 
    210                 215                 220                 


Glu Ala Gly Gly Thr Leu Glu Leu His Gly Ala Arg Lys Ala Ser Trp 
225                 230                 235                 240 


Thr Leu Leu Ala Arg Thr Leu Asn Ser Ser Gly Leu Pro Phe Gly Ser 
                245                 250                 255     


Tyr Thr Phe Glu Lys Asp Phe Ser Arg Gly Leu Asn Val Arg Val Ile 
            260                 265                 270         


Asp Gln Asp Thr Ala Lys Ile Leu Glu Ser Glu Arg Phe Asp Thr His 
        275                 280                 285             


Glu Tyr Arg Asn Glu Ser Arg Arg Leu Gln Glu Phe Leu Arg Phe Gln 
    290                 295                 300                 


Asp Pro Gly Arg Ile Val Ala Ile Ala Val Gly Asp Ser Ala Ala Lys 
305                 310                 315                 320 


Ser Leu Leu Gln Gly Thr Ile Gln Met Ile Gln Glu Arg Leu Gly Ser 
                325                 330                 335     


Glu Leu Ile Gln Gly Leu Gly Tyr Arg Gln Ala Trp Ala Leu Val Gly 
            340                 345                 350         


Val Ile Asp Gly Gly Ser Thr Ser Cys Asn Glu Ser Val Arg Asn Tyr 
        355                 360                 365             


Glu Asn His Ser Ser Gly Gly Lys Ala Leu Ala Gln Arg Glu Phe Tyr 
    370                 375                 380                 


Thr Val Asp Gly Gln Lys Phe Ser Val Thr Ala Tyr Ser Glu Trp Ile 
385                 390                 395                 400 


Glu Glu Thr Pro Gln Phe Leu His Met Gly Glu Ile Ile Asp Gly Val 
                405                 410                 415     


Asp Met Arg Ala Glu Val Gly Ile Leu Thr Arg Asn Ile Val Ile Gln 
            420                 425                 430         


Gly Glu Val Glu Asp Ser Cys Tyr Ala Glu Asn Gln Cys Gln Phe Phe 
        435                 440                 445             


Asp Tyr Asp Thr Phe Gly Gly His Ile Met Ile Met Lys Asn Phe Thr 
    450                 455                 460                 


Ser Val His Leu Ser Tyr Val Glu Leu Lys His Met Gly Gln Gln Gln 
465                 470                 475                 480 


Met Gly Arg Tyr Pro Val His Phe His Leu Cys Gly Asp Val Asp Tyr 
                485                 490                 495     


Lys Gly Gly Tyr Arg His Ala Thr Phe Val Asp Gly Leu Ser Ile His 
            500                 505                 510         


His Ser Phe Ser Arg Cys Ile Thr Val His Gly Thr Asn Gly Leu Leu 
        515                 520                 525             


Ile Lys Asp Thr Ile Gly Phe Asp Thr Leu Gly His Cys Phe Phe Leu 
    530                 535                 540                 


Glu Asp Gly Ile Glu Gln Arg Asn Thr Leu Phe His Asn Leu Gly Leu 
545                 550                 555                 560 


Leu Thr Lys Pro Gly Thr Leu Leu Pro Thr Asp Arg Asn Asn Ser Met 
                565                 570                 575     


Cys Thr Thr Met Arg Asp Lys Val Phe Gly Asn Tyr Ile Pro Val Pro 
            580                 585                 590         


Ala Thr Asp Cys Met Ala Val Ser Thr Phe Trp Ile Ala His Pro Asn 
        595                 600                 605             


Asn Asn Leu Ile Asn Asn Ala Ala Ala Gly Ser Gln Asp Ala Gly Ile 
    610                 615                 620                 


Trp Tyr Leu Phe His Lys Glu Pro Thr Gly Glu Ser Ser Gly Leu Gln 
625                 630                 635                 640 


Leu Leu Ala Lys Pro Glu Leu Thr Pro Leu Gly Ile Phe Tyr Asn Asn 
                645                 650                 655     


Arg Val His Ser Asn Phe Lys Ala Gly Leu Phe Ile Asp Lys Gly Val 
            660                 665                 670         


Lys Thr Thr Asn Ser Ser Ala Ala Asp Pro Arg Glu Tyr Leu Cys Leu 
        675                 680                 685             


Asp Asn Ser Ala Arg Phe Arg Pro His Gln Asp Ala Asn Pro Glu Lys 
    690                 695                 700                 


Pro Arg Val Ala Ala Leu Ile Asp Arg Leu Ile Ala Phe Lys Asn Asn 
705                 710                 715                 720 


Asp Asn Gly Ala Trp Val Arg Gly Gly Asp Ile Ile Val Gln Asn Ser 
                725                 730                 735     


Ala Phe Ala Asp Asn Gly Ile Gly Leu Thr Phe Ala Ser Asp Gly Ser 
            740                 745                 750         


Phe Pro Ser Asp Glu Gly Ser Ser Gln Glu Val Ser Glu Ser Leu Phe 
        755                 760                 765             


Val Gly Glu Ser Arg Asn Tyr Gly Phe Gln Gly Gly Gln Asn Lys Tyr 
    770                 775                 780                 


Val Gly Thr Gly Gly Ile Asp Gln Lys Pro Arg Thr Leu Pro Arg Asn 
785                 790                 795                 800 


Arg Thr Phe Pro Ile Arg Gly Phe Gln Ile Tyr Asp Gly Pro Ile His 
                805                 810                 815     


Leu Thr Arg Ser Thr Phe Lys Lys Tyr Val Pro Thr Pro Asp Arg Tyr 
            820                 825                 830         


Ser Ser Ala Ile Gly Phe Leu Met Lys Asn Ser Trp Gln Ile Thr Pro 
        835                 840                 845             


Arg Asn Asn Ile Ser Leu Val Lys Phe Gly Pro His Val Ser Leu Asn 
    850                 855                 860                 


Val Phe Phe Gly Lys Pro Gly Pro Trp Phe Glu Asp Cys Glu Met Asp 
865                 870                 875                 880 


Gly Asp Lys Asn Ser Ile Phe His Asp Ile Asp Gly Ser Val Thr Gly 
                885                 890                 895     


Tyr Lys Asp Ala Tyr Val Gly Arg Met Asp Asn Tyr Leu Ile Arg His 
            900                 905                 910         


Pro Ser Cys Val Asn Val Ser Lys Trp Asn Ala Val Ile Cys Ser Gly 
        915                 920                 925             


Thr Tyr Ala Gln Val Tyr Val Gln Thr Trp Ser Thr Gln Asn Leu Ser 
    930                 935                 940                 


Met Thr Ile Thr Arg Asp Glu Tyr Pro Ser Asn Pro Met Val Leu Arg 
945                 950                 955                 960 


Gly Ile Asn Gln Lys Ala Ala Phe Pro Gln Tyr Gln Pro Val Val Met 
                965                 970                 975     


Leu Glu Lys Gly Tyr Thr Ile His Trp Asn Gly Pro Ala Pro Arg Thr 
            980                 985                 990         


Thr Phe Leu Tyr Leu Val Asn Phe  Asn Lys Asn Asp Trp  Ile Arg Val 
        995                 1000                 1005             


Gly Leu  Cys Tyr Pro Ser Asn  Thr Ser Phe Gln Val  Thr Phe Gly 
    1010                 1015                 1020             


Tyr Leu  Gln Arg Gln Asn Gly  Ser Leu Ser Lys Ile  Glu Glu Tyr 
    1025                 1030                 1035             


Glu Pro  Val His Ser Leu Glu  Glu Leu Gln Arg Lys  Gln Ser Glu 
    1040                 1045                 1050             


Arg Lys  Phe Tyr Phe Asp Ser  Ser Thr Gly Leu Leu  Phe Leu Tyr 
    1055                 1060                 1065             


Leu Lys  Ala Lys Ser His Arg  His Gly His Ser Tyr  Cys Ser Ser 
    1070                 1075                 1080             


Gln Gly  Cys Glu Arg Val Lys  Ile Gln Ala Ala Thr  Asp Ser Lys 
    1085                 1090                 1095             


Asp Ile  Ser Asn Cys Met Ala  Lys Ala Tyr Pro Gln  Tyr Tyr Arg 
    1100                 1105                 1110             


Lys Pro  Ser Val Val Lys Arg  Met Pro Ala Met Leu  Thr Gly Leu 
    1115                 1120                 1125             


Cys Gln  Gly Cys Gly Thr Arg  Gln Val Val Phe Thr  Ser Asp Pro 
    1130                 1135                 1140             


His Lys  Ser Tyr Leu Pro Val  Gln Phe Gln Ser Pro  Asp Lys Ala 
    1145                 1150                 1155             


Glu Thr  Gln Arg Gly Asp Pro  Ser Val Ile Ser Val  Asn Gly Thr 
    1160                 1165                 1170             


Asp Phe  Thr Phe Arg Ser Ala  Gly Val Leu Leu Leu  Val Val Asp 
    1175                 1180                 1185             


Pro Cys  Ser Val Pro Phe Arg  Leu Thr Glu Lys Thr  Val Phe Pro 
    1190                 1195                 1200             


Leu Ala  Asp Val Ser Arg Ile  Glu Glu Tyr Leu Lys  Thr Gly Ile 
    1205                 1210                 1215             


Pro Pro  Arg Ser Ile Val Leu  Leu Ser Thr Arg Gly  Glu Ile Lys 
    1220                 1225                 1230             


Gln Leu  Asn Ile Ser His Leu  Leu Val Pro Leu Gly  Leu Ala Lys 
    1235                 1240                 1245             


Pro Ala  His Leu Tyr Asp Lys  Gly Ser Thr Ile Phe  Leu Gly Phe 
    1250                 1255                 1260             


Ser Gly  Asn Phe Lys Pro Ser  Trp Thr Lys Leu Phe  Thr Ser Pro 
    1265                 1270                 1275             


Ala Gly  Gln Gly Leu Gly Val  Leu Glu Gln Phe Ile  Pro Leu Gln 
    1280                 1285                 1290             


Leu Asp  Glu Tyr Gly Cys Pro  Arg Ala Thr Thr Val  Arg Arg Arg 
    1295                 1300                 1305             


Asp Leu  Glu Leu Leu Lys Gln  Ala Ser Lys Ala His  
    1310                 1315                 1320 


<210>  1570
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  1570

Met Pro Leu Ser Arg Trp Leu Arg Ser Val Gly Val Phe Leu Leu Pro 
1               5                   10                  15      


Ala Pro Tyr Trp Ala Pro Arg Glu Arg Trp Leu Gly Ser Leu Arg Arg 
            20                  25                  30          


Pro Ser Leu Val His Gly Tyr Pro Val Leu Ala Trp His Ser Ala Arg 
        35                  40                  45              


Cys Trp Cys Gln Ala Trp Thr Glu Glu Pro Arg Ala Leu Cys Ser Ser 
    50                  55                  60                  


Leu Arg Met Asn Gly Asp Gln Asn Ser Asp Val Tyr Ala Gln Glu Lys 
65                  70                  75                  80  


Gln Asp Phe Val Gln His Phe Ser Gln Ile Val Arg Val Leu Thr Glu 
                85                  90                  95      


Asp Glu Met Gly His Pro Glu Ile Gly Asp Ala Ile Ala Arg Leu Lys 
            100                 105                 110         


Glu Val Leu Glu Tyr Asn Ala Ile Gly Gly Lys Tyr Asn Arg Gly Leu 
        115                 120                 125             


Thr Val Val Val Ala Phe Arg Glu Leu Val Glu Pro Arg Lys Gln Asp 
    130                 135                 140                 


Ala Asp Ser Leu Gln Arg Ala Trp Thr Val Gly Trp Cys Val Glu Leu 
145                 150                 155                 160 


Leu Gln Ala Phe Phe Leu Val Ala Asp Asp Ile Met Asp Ser Ser Leu 
                165                 170                 175     


Thr Arg Arg Gly Gln Ile Cys Trp Tyr Gln Lys Pro Gly Val Gly Leu 
            180                 185                 190         


Asp Ala Ile Asn Asp Ala Asn Leu Leu Glu Ala Cys Ile Tyr Arg Leu 
        195                 200                 205             


Leu Lys Leu Tyr Cys Arg Glu Gln Pro Tyr Tyr Leu Asn Leu Ile Glu 
    210                 215                 220                 


Leu Phe Leu Gln Ser Ser Tyr Gln Thr Glu Ile Gly Gln Thr Leu Asp 
225                 230                 235                 240 


Leu Leu Thr Ala Pro Gln Gly Asn Val Asp Leu Val Arg Phe Thr Glu 
                245                 250                 255     


Lys Arg Tyr Lys Ser Ile Val Lys Tyr Lys Thr Ala Phe Tyr Ser Phe 
            260                 265                 270         


Tyr Leu Pro Ile Ala Ala Ala Met Tyr Met Ala Gly Ile Asp Gly Glu 
        275                 280                 285             


Lys Glu His Ala Asn Ala Lys Lys Ile Leu Leu Glu Met Gly Glu Phe 
    290                 295                 300                 


Phe Gln Ile Gln Asp Asp Tyr Leu Asp Leu Phe Gly Asp Pro Ser Val 
305                 310                 315                 320 


Thr Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Leu 
                325                 330                 335     


Val Val Gln Cys Leu Gln Arg Ala Thr Pro Glu Gln Tyr Gln Ile Leu 
            340                 345                 350         


Lys Glu Asn Tyr Gly Gln Lys Glu Ala Glu Lys Val Ala Arg Val Lys 
        355                 360                 365             


Ala Leu Tyr Glu Glu Leu Asp Leu Pro Ala Val Phe Leu Gln Tyr Glu 
    370                 375                 380                 


Glu Asp Ser Tyr Ser His Ile Met Ala Leu Ile Glu Gln Tyr Ala Ala 
385                 390                 395                 400 


Pro Leu Pro Pro Ala Val Phe Leu Gly Leu Ala Arg Lys Ile Tyr Lys 
                405                 410                 415     


Arg Arg Lys 
            


<210>  1571
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  1571

Met Asn Gly Asp Gln Asn Ser Asp Val Tyr Ala Gln Glu Lys Gln Asp 
1               5                   10                  15      


Phe Val Gln His Phe Ser Gln Ile Val Arg Val Leu Thr Glu Asp Glu 
            20                  25                  30          


Met Gly His Pro Glu Ile Gly Asp Ala Ile Ala Arg Leu Lys Glu Val 
        35                  40                  45              


Leu Glu Tyr Asn Ala Ile Gly Gly Lys Tyr Asn Arg Gly Leu Thr Val 
    50                  55                  60                  


Val Val Ala Phe Arg Glu Leu Val Glu Pro Arg Lys Gln Asp Ala Asp 
65                  70                  75                  80  


Ser Leu Gln Arg Ala Trp Thr Val Gly Trp Cys Val Glu Leu Leu Gln 
                85                  90                  95      


Ala Phe Phe Leu Val Ala Asp Asp Ile Met Asp Ser Ser Leu Thr Arg 
            100                 105                 110         


Arg Gly Gln Ile Cys Trp Tyr Gln Lys Pro Gly Val Gly Leu Asp Ala 
        115                 120                 125             


Ile Asn Asp Ala Asn Leu Leu Glu Ala Cys Ile Tyr Arg Leu Leu Lys 
    130                 135                 140                 


Leu Tyr Cys Arg Glu Gln Pro Tyr Tyr Leu Asn Leu Ile Glu Leu Phe 
145                 150                 155                 160 


Leu Gln Ser Ser Tyr Gln Thr Glu Ile Gly Gln Thr Leu Asp Leu Leu 
                165                 170                 175     


Thr Ala Pro Gln Gly Asn Val Asp Leu Val Arg Phe Thr Glu Lys Arg 
            180                 185                 190         


Tyr Lys Ser Ile Val Lys Tyr Lys Thr Ala Phe Tyr Ser Phe Tyr Leu 
        195                 200                 205             


Pro Ile Ala Ala Ala Met Tyr Met Ala Gly Ile Asp Gly Glu Lys Glu 
    210                 215                 220                 


His Ala Asn Ala Lys Lys Ile Leu Leu Glu Met Gly Glu Phe Phe Gln 
225                 230                 235                 240 


Ile Gln Asp Asp Tyr Leu Asp Leu Phe Gly Asp Pro Ser Val Thr Gly 
                245                 250                 255     


Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Leu Val Val 
            260                 265                 270         


Gln Cys Leu Gln Arg Ala Thr Pro Glu Gln Tyr Gln Ile Leu Lys Glu 
        275                 280                 285             


Asn Tyr Gly Gln Lys Glu Ala Glu Lys Val Ala Arg Val Lys Ala Leu 
    290                 295                 300                 


Tyr Glu Glu Leu Asp Leu Pro Ala Val Phe Leu Gln Tyr Glu Glu Asp 
305                 310                 315                 320 


Ser Tyr Ser His Ile Met Ala Leu Ile Glu Gln Tyr Ala Ala Pro Leu 
                325                 330                 335     


Pro Pro Ala Val Phe Leu Gly Leu Ala Arg Lys Ile Tyr Lys Arg Arg 
            340                 345                 350         


Lys 
    


<210>  1572
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  1572

Met Leu Cys Val Ser Tyr Gln Val Asp Glu Arg Thr Cys Ile Gln Phe 
1               5                   10                  15      


Ser Met Lys Leu Leu Tyr Phe Leu Leu Ser Ala Leu Gly Leu Thr Val 
            20                  25                  30          


Cys Val Leu Ala Val Ala Phe Ala Ala His His Tyr Ser Gln Leu Thr 
        35                  40                  45              


Gln Phe Thr Cys Glu Thr Thr Leu Asp Ser Cys Gln Cys Lys Leu Pro 
    50                  55                  60                  


Ser Ser Glu Pro Leu Ser Arg Thr Phe Val Tyr Arg Asp Val Thr Asp 
65                  70                  75                  80  


Cys Thr Ser Val Thr Gly Thr Phe Lys Leu Phe Leu Leu Ile Gln Met 
                85                  90                  95      


Ile Leu Asn Leu Val Cys Gly Leu Val Cys Leu Leu Ala Cys Phe Val 
            100                 105                 110         


Met Trp Lys His Arg Tyr Gln Val Phe Tyr Val Gly Val Arg Ile Cys 
        115                 120                 125             


Ser Leu Thr Ala Ser Glu Gly Pro Gln Gln Lys Ile 
    130                 135                 140 


<210>  1573
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  1573

Met Pro Val Pro Ala Ser Trp Pro His Leu Pro Ser Pro Phe Leu Leu 
1               5                   10                  15      


Met Thr Leu Leu Leu Gly Arg Leu Thr Gly Val Ala Gly Glu Glu Glu 
            20                  25                  30          


Leu Gln Val Ile Gln Pro Asp Lys Ser Ile Ser Val Ala Ala Gly Glu 
        35                  40                  45              


Ser Ala Thr Leu His Cys Thr Val Thr Ser Leu Ile Pro Val Gly Pro 
    50                  55                  60                  


Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu Thr 
                85                  90                  95      


Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Ser Asn Ile Thr Pro 
            100                 105                 110         


Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser Pro 
        115                 120                 125             


Asp His Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val Arg 
    130                 135                 140                 


Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala Thr 
145                 150                 155                 160 


Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro 
                165                 170                 175     


Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp 
            180                 185                 190         


Phe Gln Thr Asn Val Asp Pro Ala Gly Asp Ser Val Ser Tyr Ser Ile 
        195                 200                 205             


His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser Gln 
    210                 215                 220                 


Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg 
225                 230                 235                 240 


Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu Glu 
                245                 250                 255     


Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr Cys 
            260                 265                 270         


Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu Glu 
        275                 280                 285             


Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Leu Thr Glu Asn 
    290                 295                 300                 


Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val Ser 
305                 310                 315                 320 


Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp Gly 
                325                 330                 335     


Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His Pro 
            340                 345                 350         


Lys Glu Gln Gly Ser Asn Thr Ala Pro Gly Pro Ala Leu Ala Ser Ala 
        355                 360                 365             


Ala Pro Leu Leu Ile Ala Phe Leu Leu Gly Pro Lys Val Leu Leu Val 
    370                 375                 380                 


Val Gly Val Ser Val Ile Tyr Val Tyr Trp Lys Gln Lys Ala 
385                 390                 395             


<210>  1574
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  1574

Met Leu Leu Ala Trp Val Gln Ala Phe Leu Val Ser Asn Met Leu Leu 
1               5                   10                  15      


Ala Glu Ala Tyr Gly Ser Gly Gly Cys Phe Trp Asp Asn Gly His Leu 
            20                  25                  30          


Tyr Arg Glu Asp Gln Thr Ser Pro Ala Pro Gly Leu Arg Cys Leu Asn 
        35                  40                  45              


Trp Leu Asp Ala Gln Ser Gly Leu Ala Ser Ala Pro Val Ser Gly Ala 
    50                  55                  60                  


Gly Asn His Ser Tyr Cys Arg Asn Pro Asp Glu Asp Pro Arg Gly Pro 
65                  70                  75                  80  


Trp Cys Tyr Val Ser Gly Glu Ala Gly Val Pro Glu Lys Arg Pro Cys 
                85                  90                  95      


Glu Asp Leu Arg Cys Pro Glu Thr Thr Ser Gln Ala Leu Pro Ala Phe 
            100                 105                 110         


Thr Thr Glu Ile Gln Glu Ala Ser Glu Gly Pro Gly Ala Asp Glu Val 
        115                 120                 125             


Gln Val Phe Ala Pro Ala Asn Ala Leu Pro Ala Arg Ser Glu Ala Ala 
    130                 135                 140                 


Ala Val Gln Pro Val Ile Gly Ile Ser Gln Arg Val Arg Met Asn Ser 
145                 150                 155                 160 


Lys Glu Lys Lys Asp Leu Gly Thr Leu Gly Gly Arg Ile 
                165                 170             


<210>  1575
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  1575

Met Ala Ala Asp Gly Gln Cys Ser Leu Pro Ala Ser Trp Arg Pro Val 
1               5                   10                  15      


Thr Leu Thr His Val Glu Tyr Pro Ala Gly Asp Leu Ser Gly His Leu 
            20                  25                  30          


Leu Ala Tyr Leu Ser Leu Ser Pro Val Phe Val Ile Val Gly Phe Val 
        35                  40                  45              


Thr Leu Ile Ile Phe Lys Arg Glu Leu His Thr Ile Ser Phe Leu Gly 
    50                  55                  60                  


Gly Leu Ala Leu Asn Glu Gly Val Asn Trp Leu Ile Lys Asn Val Ile 
65                  70                  75                  80  


Gln Glu Pro Arg Pro Cys Gly Gly Pro His Thr Ala Val Gly Thr Lys 
                85                  90                  95      


Tyr Gly Met Pro Ser Ser His Ser Gln Phe Met Trp Phe Phe Ser Val 
            100                 105                 110         


Tyr Ser Phe Leu Phe Leu Tyr Leu Arg Met His Gln Thr Asn Asn Ala 
        115                 120                 125             


Arg Phe Leu Asp Leu Leu Trp Arg His Val Leu Ser Leu Gly Leu Leu 
    130                 135                 140                 


Ala Val Ala Phe Leu Val Ser Tyr Ser Arg Pro Val Ser Glu Phe Phe 
145                 150                 155                 160 


Leu Ile Arg Asp Thr Ser Leu Ile Pro Asn Val Leu Trp Phe Glu Tyr 
                165                 170                 175     


Thr Val Thr Arg Ala Glu Ala Arg Asn Arg Gln Arg Lys Leu Gly Thr 
            180                 185                 190         


Lys Leu Gln 
        195 


<210>  1576
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  1576

Met Lys Ile Leu Phe Val Glu Pro Ala Ile Phe Leu Ser Ala Phe Ala 
1               5                   10                  15      


Met Thr Leu Thr Gly Pro Leu Thr Thr Gln Tyr Val Tyr Arg Arg Ile 
            20                  25                  30          


Trp Glu Glu Thr Gly Asn Tyr Thr Phe Ser Ser Asp Ser Asn Ile Ser 
        35                  40                  45              


Glu Cys Glu Lys Asn Lys Ser Ser Pro Ile Phe Ala Phe Gln Glu Glu 
    50                  55                  60                  


Val Gln Lys Lys Val Ser Arg Phe Asn Leu Gln Met Asp Ile Ser Gly 
65                  70                  75                  80  


Leu Ile Pro Gly Leu Val Ser Thr Phe Ile Leu Leu Ser Ile Ser Asp 
                85                  90                  95      


His Tyr Gly Arg Lys Phe Pro Met Ile Leu Ser Ser Val Gly Ala Leu 
            100                 105                 110         


Ala Thr Ser Val Trp Leu Cys Leu Leu Cys Tyr Phe Ala Phe Pro Phe 
        115                 120                 125             


Gln Leu Leu Ile Ala Ser Thr Phe Ile Gly Ala Phe Cys Gly Asn Tyr 
    130                 135                 140                 


Thr Thr Phe Trp Gly Ala Cys Phe Ala Tyr Ile Val Asp Gln Cys Lys 
145                 150                 155                 160 


Glu His Lys Gln Lys Thr Ile Arg Ile Ala Ile Ile Asp Phe Leu Leu 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Thr Gly Leu Ser Ser Gly Tyr Phe Ile Arg 
            180                 185                 190         


Glu Leu Gly Phe Glu Trp Ser Phe Leu Ile Ile Ala Val Ser Leu Ala 
        195                 200                 205             


Val Asn Leu Ile Tyr Ile Leu Phe Phe Leu Gly Asp Pro Val Lys Glu 
    210                 215                 220                 


Cys Ser Ser Gln Asn Val Thr Met Ser Cys Ser Glu Gly Phe Lys Asn 
225                 230                 235                 240 


Leu Phe Tyr Arg Thr Tyr Met Leu Phe Lys Asn Ala Ser Gly Lys Arg 
                245                 250                 255     


Arg Phe Leu Leu Cys Leu Leu Leu Phe Thr Val Ile Thr Tyr Phe Phe 
            260                 265                 270         


Val Val Ile Gly Ile Ala Pro Ile Phe Ile Leu Tyr Glu Leu Asp Ser 
        275                 280                 285             


Pro Leu Cys Trp Asn Glu Val Phe Ile Gly Tyr Gly Ser Ala Leu Gly 
    290                 295                 300                 


Ser Ala Ser Phe Leu Thr Ser Phe Leu Gly Ile Trp Leu Phe Ser Tyr 
305                 310                 315                 320 


Cys Met Glu Asp Ile His Met Ala Phe Ile Gly Ile Phe Thr Thr Met 
                325                 330                 335     


Thr Gly Met Ala Met Thr Ala Phe Ala Ser Thr Thr Leu Met Met Phe 
            340                 345                 350         


Leu Ala Arg Val Pro Phe Leu Phe Thr Ile Val Pro Phe Ser Val Leu 
        355                 360                 365             


Arg Ser Met Leu Ser Lys Val Val Arg Ser Thr Glu Gln Gly Thr Leu 
    370                 375                 380                 


Phe Ala Cys Ile Ala Phe Leu Glu Thr Leu Gly Gly Val Thr Ala Val 
385                 390                 395                 400 


Ser Thr Phe Asn Gly Ile Tyr Ser Ala Thr Val Ala Trp Tyr Pro Gly 
                405                 410                 415     


Phe Thr Phe Leu Leu Ser Ala Gly Leu Leu Leu Leu Pro Ala Ile Ser 
            420                 425                 430         


Leu Cys Val Val Lys Cys Thr Ser Trp Asn Glu Gly Ser Tyr Glu Leu 
        435                 440                 445             


Leu Ile Gln Glu Glu Ser Ser Glu Asp Ala Ser Asp Arg Ala Cys 
    450                 455                 460             


<210>  1577
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  1577

Met Ser Ser Ile Leu Pro Phe Thr Pro Pro Val Val Lys Arg Leu Leu 
1               5                   10                  15      


Gly Trp Lys Lys Ser Ala Gly Gly Ser Gly Gly Ala Gly Gly Gly Glu 
            20                  25                  30          


Gln Asn Gly Gln Glu Glu Lys Trp Cys Glu Lys Ala Val Lys Ser Leu 
        35                  40                  45              


Val Lys Lys Leu Lys Lys Thr Gly Arg Leu Asp Glu Leu Glu Lys Ala 
    50                  55                  60                  


Ile Thr Thr Gln Asn Cys Asn Thr Lys Cys Val Thr Ile Pro Arg Ser 
65                  70                  75                  80  


Leu Asp Gly Arg Leu Gln Val Ser His Arg Lys Gly Leu Pro His Val 
                85                  90                  95      


Ile Tyr Cys Arg Leu Trp Arg Trp Pro Asp Leu His Ser His His Glu 
            100                 105                 110         


Leu Lys Ala Ile Glu Asn Cys Glu Tyr Ala Phe Asn Leu Lys Lys Asp 
        115                 120                 125             


Glu Val Cys Val Asn Pro Tyr His Tyr Gln Arg Val Glu Thr Pro Val 
    130                 135                 140                 


Leu Pro Pro Val Leu Val Pro Arg His Thr Glu Ile Leu Thr Glu Leu 
145                 150                 155                 160 


Pro Pro Leu Asp Asp Tyr Thr His Ser Ile Pro Glu Asn Thr Asn Phe 
                165                 170                 175     


Pro Ala Gly Ile Glu Pro Gln Ser Asn Tyr Ile Pro Glu Thr Pro Pro 
            180                 185                 190         


Pro Gly Tyr Ile Ser Glu Asp Gly Glu Thr Ser Asp Gln Gln Leu Asn 
        195                 200                 205             


Gln Ser Met Asp Thr Gly Ser Pro Ala Glu Leu Ser Pro Thr Thr Leu 
    210                 215                 220                 


Ser Pro Val Asn His Ser Leu Asp Leu Gln Pro Val Thr Tyr Ser Glu 
225                 230                 235                 240 


Pro Ala Phe Trp Cys Ser Ile Ala Tyr Tyr Glu Leu Asn Gln Arg Val 
                245                 250                 255     


Gly Glu Thr Phe His Ala Ser Gln Pro Ser Leu Thr Val Asp Gly Phe 
            260                 265                 270         


Thr Asp Pro Ser Asn Ser Glu Arg Phe Cys Leu Gly Leu Leu Ser Asn 
        275                 280                 285             


Val Asn Arg Asn Ala Thr Val Glu Met Thr Arg Arg His Ile Gly Arg 
    290                 295                 300                 


Gly Val Arg Leu Tyr Tyr Ile Gly Gly Glu Val Phe Ala Glu Cys Leu 
305                 310                 315                 320 


Ser Asp Ser Ala Ile Phe Val Gln Ser Pro Asn Cys Asn Gln Arg Tyr 
                325                 330                 335     


Gly Trp His Pro Ala Thr Val Cys Lys Ile Pro Pro Gly Cys Asn Leu 
            340                 345                 350         


Lys Ile Phe Asn Asn Gln Glu Phe Ala Ala Leu Leu Ala Gln Ser Val 
        355                 360                 365             


Asn Gln Gly Phe Glu Ala Val Tyr Gln Leu Thr Arg Met Cys Thr Ile 
    370                 375                 380                 


Arg Met Ser Phe Val Lys Gly Trp Gly Ala Glu Tyr Arg Arg Gln Thr 
385                 390                 395                 400 


Val Thr Ser Thr Pro Cys Trp Ile Glu Leu His Leu Asn Gly Pro Leu 
                405                 410                 415     


Gln Trp Leu Asp Lys Val Leu Thr Gln Met Gly Ser Pro Ser Val Arg 
            420                 425                 430         


Cys Ser Ser Met Ser 
        435         


<210>  1578
<211>  893
<212>  PRT
<213>  Homo sapiens

<400>  1578

Met Ala Gln Phe Tyr Tyr Lys Arg Asn Val Asn Ala Pro Tyr Arg Asp 
1               5                   10                  15      


Arg Ile Pro Leu Arg Ile Val Arg Ala Glu Ser Glu Leu Ser Pro Ser 
            20                  25                  30          


Glu Lys Ala Tyr Leu Asn Ala Val Glu Lys Gly Asp Tyr Ala Ser Val 
        35                  40                  45              


Lys Lys Ser Leu Glu Glu Ala Glu Ile Tyr Phe Lys Ile Asn Ile Asn 
    50                  55                  60                  


Cys Ile Asp Pro Leu Gly Arg Thr Ala Leu Leu Ile Ala Ile Glu Asn 
65                  70                  75                  80  


Glu Asn Leu Glu Leu Ile Glu Leu Leu Leu Ser Phe Asn Val Tyr Val 
                85                  90                  95      


Gly Asp Ala Leu Leu His Ala Ile Arg Lys Glu Val Val Gly Ala Val 
            100                 105                 110         


Glu Leu Leu Leu Asn His Lys Lys Pro Ser Gly Glu Lys Gln Val Pro 
        115                 120                 125             


Pro Ile Leu Leu Asp Lys Gln Phe Ser Glu Phe Thr Pro Asp Ile Thr 
    130                 135                 140                 


Pro Ile Ile Leu Ala Ala His Thr Asn Asn Tyr Glu Ile Ile Lys Leu 
145                 150                 155                 160 


Leu Val Gln Lys Gly Val Ser Val Pro Arg Pro His Glu Val Arg Cys 
                165                 170                 175     


Asn Cys Val Glu Cys Val Ser Ser Ser Asp Val Asp Ser Leu Arg His 
            180                 185                 190         


Ser Arg Ser Arg Leu Asn Ile Tyr Lys Ala Leu Ala Ser Pro Ser Leu 
        195                 200                 205             


Ile Ala Leu Ser Ser Glu Asp Pro Phe Leu Thr Ala Phe Gln Leu Ser 
    210                 215                 220                 


Trp Glu Leu Gln Glu Leu Ser Lys Val Glu Asn Glu Phe Lys Ser Glu 
225                 230                 235                 240 


Tyr Glu Glu Leu Ser Arg Gln Cys Lys Gln Phe Ala Lys Asp Leu Leu 
                245                 250                 255     


Asp Gln Thr Arg Ser Ser Arg Glu Leu Glu Ile Ile Leu Asn Tyr Arg 
            260                 265                 270         


Asp Asp Asn Ser Leu Ile Glu Glu Gln Ser Gly Asn Asp Leu Ala Arg 
        275                 280                 285             


Leu Lys Leu Ala Ile Lys Tyr Arg Gln Lys Glu Phe Val Ala Gln Pro 
    290                 295                 300                 


Asn Cys Gln Gln Leu Leu Ala Ser Arg Trp Tyr Asp Glu Phe Pro Gly 
305                 310                 315                 320 


Trp Arg Arg Arg His Trp Ala Val Lys Met Val Thr Cys Phe Ile Ile 
                325                 330                 335     


Gly Leu Leu Phe Pro Val Phe Ser Val Cys Tyr Leu Ile Ala Pro Lys 
            340                 345                 350         


Ser Pro Leu Gly Leu Phe Ile Arg Lys Pro Phe Ile Lys Phe Ile Cys 
        355                 360                 365             


His Thr Ala Ser Tyr Leu Thr Phe Leu Phe Leu Leu Leu Leu Ala Ser 
    370                 375                 380                 


Gln His Ile Asp Arg Ser Asp Leu Asn Arg Gln Gly Pro Pro Pro Thr 
385                 390                 395                 400 


Ile Val Glu Trp Met Ile Leu Pro Trp Val Leu Gly Phe Ile Trp Gly 
                405                 410                 415     


Glu Ile Lys Gln Met Trp Asp Gly Gly Leu Gln Asp Tyr Ile His Asp 
            420                 425                 430         


Trp Trp Asn Leu Met Asp Phe Val Met Asn Ser Leu Tyr Leu Ala Thr 
        435                 440                 445             


Ile Ser Leu Lys Ile Val Ala Phe Val Lys Tyr Ser Ala Leu Asn Pro 
    450                 455                 460                 


Arg Glu Ser Trp Asp Met Trp His Pro Thr Leu Val Ala Glu Ala Leu 
465                 470                 475                 480 


Phe Ala Ile Ala Asn Ile Phe Ser Ser Leu Arg Leu Ile Ser Leu Phe 
                485                 490                 495     


Thr Ala Asn Ser His Leu Gly Pro Leu Gln Ile Ser Leu Gly Arg Met 
            500                 505                 510         


Leu Leu Asp Ile Leu Lys Phe Leu Phe Ile Tyr Cys Leu Val Leu Leu 
        515                 520                 525             


Ala Phe Ala Asn Gly Leu Asn Gln Leu Tyr Phe Tyr Tyr Glu Glu Thr 
    530                 535                 540                 


Lys Gly Leu Thr Cys Lys Gly Ile Arg Cys Glu Lys Gln Asn Asn Ala 
545                 550                 555                 560 


Phe Ser Thr Leu Phe Glu Thr Leu Gln Ser Leu Phe Trp Ser Ile Phe 
                565                 570                 575     


Gly Leu Ile Asn Leu Tyr Val Thr Asn Val Lys Ala Gln His Glu Phe 
            580                 585                 590         


Thr Glu Phe Val Gly Ala Thr Met Phe Gly Thr Tyr Asn Val Ile Ser 
        595                 600                 605             


Leu Val Val Leu Leu Asn Met Leu Ile Ala Met Met Asn Asn Ser Tyr 
    610                 615                 620                 


Gln Leu Ile Ala Asp His Ala Asp Ile Glu Trp Lys Phe Ala Arg Thr 
625                 630                 635                 640 


Lys Leu Trp Met Ser Tyr Phe Glu Glu Gly Gly Thr Leu Pro Thr Pro 
                645                 650                 655     


Phe Asn Val Ile Pro Ser Pro Lys Ser Leu Trp Tyr Leu Ile Lys Trp 
            660                 665                 670         


Ile Trp Thr His Leu Cys Lys Lys Lys Met Arg Arg Lys Pro Glu Ser 
        675                 680                 685             


Phe Gly Thr Ile Gly Arg Arg Ala Ala Asp Asn Leu Arg Arg His His 
    690                 695                 700                 


Gln Tyr Gln Glu Val Met Arg Asn Leu Val Lys Arg Tyr Val Ala Ala 
705                 710                 715                 720 


Met Ile Arg Asp Ala Lys Thr Glu Glu Gly Leu Thr Glu Glu Asn Phe 
                725                 730                 735     


Lys Glu Leu Lys Gln Asp Ile Ser Ser Phe Arg Phe Glu Val Leu Gly 
            740                 745                 750         


Leu Leu Arg Gly Ser Lys Leu Ser Thr Ile Gln Ser Ala Asn Ala Ser 
        755                 760                 765             


Lys Glu Ser Ser Asn Ser Ala Asp Ser Asp Glu Lys Ser Asp Ser Glu 
    770                 775                 780                 


Glu Glu Val Ala Arg Gln Gln Ala Ala Gly Pro Leu Glu Arg Asn Ile 
785                 790                 795                 800 


Gln Leu Glu Ser Arg Gly Leu Ala Ser Arg Gly Asp Leu Ser Ile Pro 
                805                 810                 815     


Gly Leu Ser Glu Gln Cys Val Leu Val Asp His Arg Glu Arg Asn Thr 
            820                 825                 830         


Asp Thr Leu Gly Leu Gln Val Gly Lys Arg Val Cys Pro Phe Lys Ser 
        835                 840                 845             


Glu Lys Val Val Val Glu Asp Thr Val Pro Ile Ile Pro Lys Glu Lys 
    850                 855                 860                 


His Ala Lys Glu Glu Asp Ser Ser Ile Asp Tyr Asp Leu Asn Leu Pro 
865                 870                 875                 880 


Asp Thr Val Thr His Glu Asp Tyr Val Thr Thr Arg Leu 
                885                 890             


<210>  1579
<211>  828
<212>  PRT
<213>  Homo sapiens

<400>  1579

Met Ala Gln Phe Tyr Tyr Lys Arg Asn Val Asn Ala Pro Tyr Arg Asp 
1               5                   10                  15      


Arg Ile Pro Leu Arg Ile Val Arg Ala Glu Ser Glu Leu Ser Pro Ser 
            20                  25                  30          


Glu Lys Ala Tyr Leu Asn Ala Val Glu Lys Gly Asp Tyr Ala Ser Val 
        35                  40                  45              


Lys Lys Ser Leu Glu Glu Ala Glu Ile Tyr Phe Lys Ile Asn Ile Asn 
    50                  55                  60                  


Cys Ile Asp Pro Leu Gly Arg Thr Ala Leu Leu Ile Ala Ile Glu Asn 
65                  70                  75                  80  


Glu Asn Leu Glu Leu Ile Glu Leu Leu Leu Ser Phe Asn Val Tyr Val 
                85                  90                  95      


Gly Asp Ala Leu Leu His Ala Ile Arg Lys Glu Val Val Gly Ala Val 
            100                 105                 110         


Glu Leu Leu Leu Asn His Lys Lys Pro Ser Gly Glu Lys Gln Val Pro 
        115                 120                 125             


Pro Ile Leu Leu Asp Lys Gln Phe Ser Glu Phe Thr Pro Asp Ile Thr 
    130                 135                 140                 


Pro Ile Ile Leu Ala Ala His Thr Asn Asn Tyr Glu Ile Ile Lys Leu 
145                 150                 155                 160 


Leu Val Gln Lys Gly Val Ser Val Pro Arg Pro His Glu Val Arg Cys 
                165                 170                 175     


Asn Cys Val Glu Cys Val Ser Ser Ser Asp Val Asp Ser Leu Arg His 
            180                 185                 190         


Ser Arg Ser Arg Leu Asn Ile Tyr Lys Ala Leu Ala Ser Pro Ser Leu 
        195                 200                 205             


Ile Ala Leu Ser Ser Glu Asp Pro Phe Leu Thr Ala Phe Gln Leu Ser 
    210                 215                 220                 


Trp Glu Leu Gln Glu Leu Ser Lys Val Glu Asn Glu Phe Lys Ser Glu 
225                 230                 235                 240 


Tyr Glu Glu Leu Ser Arg Gln Cys Lys Gln Phe Ala Lys Asp Leu Leu 
                245                 250                 255     


Asp Gln Thr Arg Ser Ser Arg Glu Leu Glu Ile Ile Leu Asn Tyr Arg 
            260                 265                 270         


Asp Asp Asn Ser Leu Ile Glu Glu Gln Ser Gly Asn Asp Leu Ala Arg 
        275                 280                 285             


Leu Lys Leu Ala Ile Lys Tyr Arg Gln Lys Glu Phe Val Ala Gln Pro 
    290                 295                 300                 


Asn Cys Gln Gln Leu Leu Ala Ser Arg Trp Tyr Asp Glu Phe Pro Gly 
305                 310                 315                 320 


Trp Arg Arg Arg His Trp Ala Val Lys Met Val Thr Cys Phe Ile Ile 
                325                 330                 335     


Gly Leu Leu Phe Pro Val Phe Ser Val Cys Tyr Leu Ile Ala Pro Lys 
            340                 345                 350         


Ser Pro Leu Gly Leu Phe Ile Arg Lys Pro Phe Ile Lys Phe Ile Cys 
        355                 360                 365             


His Thr Ala Ser Tyr Leu Thr Phe Leu Phe Leu Leu Leu Leu Ala Ser 
    370                 375                 380                 


Gln His Ile Asp Arg Ser Asp Leu Asn Arg Gln Gly Pro Pro Pro Thr 
385                 390                 395                 400 


Ile Val Glu Trp Met Ile Leu Pro Trp Val Leu Gly Phe Ile Trp Gly 
                405                 410                 415     


Glu Ile Lys Gln Met Trp Asp Gly Gly Leu Gln Asp Tyr Ile His Asp 
            420                 425                 430         


Trp Trp Asn Leu Met Asp Phe Val Met Asn Ser Leu Tyr Leu Ala Thr 
        435                 440                 445             


Ile Ser Leu Lys Ile Val Ala Phe Val Lys Tyr Ser Ala Leu Asn Pro 
    450                 455                 460                 


Arg Glu Ser Trp Asp Met Trp His Pro Thr Leu Val Ala Glu Ala Leu 
465                 470                 475                 480 


Phe Ala Ile Ala Asn Ile Phe Ser Ser Leu Arg Leu Ile Ser Leu Phe 
                485                 490                 495     


Thr Ala Asn Ser His Leu Gly Pro Leu Gln Ile Ser Leu Gly Arg Met 
            500                 505                 510         


Leu Leu Asp Ile Leu Lys Phe Leu Phe Ile Tyr Cys Leu Val Leu Leu 
        515                 520                 525             


Ala Phe Ala Asn Gly Leu Asn Gln Leu Tyr Phe Tyr Tyr Glu Glu Thr 
    530                 535                 540                 


Lys Gly Leu Thr Cys Lys Gly Ile Arg Cys Glu Lys Gln Asn Asn Ala 
545                 550                 555                 560 


Phe Ser Thr Leu Phe Glu Thr Leu Gln Ser Leu Phe Trp Ser Ile Phe 
                565                 570                 575     


Gly Leu Ile Asn Leu Tyr Val Thr Asn Val Lys Ala Gln His Glu Phe 
            580                 585                 590         


Thr Glu Phe Val Gly Ala Thr Met Phe Gly Thr Tyr Asn Val Ile Ser 
        595                 600                 605             


Leu Val Val Leu Leu Asn Met Leu Ile Ala Met Met Asn Asn Ser Tyr 
    610                 615                 620                 


Gln Leu Ile Ala Arg Arg Ala Ala Asp Asn Leu Arg Arg His His Gln 
625                 630                 635                 640 


Tyr Gln Glu Val Met Arg Asn Leu Val Lys Arg Tyr Val Ala Ala Met 
                645                 650                 655     


Ile Arg Asp Ala Lys Thr Glu Glu Gly Leu Thr Glu Glu Asn Phe Lys 
            660                 665                 670         


Glu Leu Lys Gln Asp Ile Ser Ser Phe Arg Phe Glu Val Leu Gly Leu 
        675                 680                 685             


Leu Arg Gly Ser Lys Leu Ser Thr Ile Gln Ser Ala Asn Ala Ser Lys 
    690                 695                 700                 


Glu Ser Ser Asn Ser Ala Asp Ser Asp Glu Lys Ser Asp Ser Glu Glu 
705                 710                 715                 720 


Glu Val Ala Arg Gln Gln Ala Ala Gly Pro Leu Glu Arg Asn Ile Gln 
                725                 730                 735     


Leu Glu Ser Arg Gly Leu Ala Ser Arg Gly Asp Leu Ser Ile Pro Gly 
            740                 745                 750         


Leu Ser Glu Gln Cys Val Leu Val Asp His Arg Glu Arg Asn Thr Asp 
        755                 760                 765             


Thr Leu Gly Leu Gln Val Gly Lys Arg Val Cys Pro Phe Lys Ser Glu 
    770                 775                 780                 


Lys Val Val Val Glu Asp Thr Val Pro Ile Ile Pro Lys Glu Lys His 
785                 790                 795                 800 


Ala Lys Glu Glu Asp Ser Ser Ile Asp Tyr Asp Leu Asn Leu Pro Asp 
                805                 810                 815     


Thr Val Thr His Glu Asp Tyr Val Thr Thr Arg Leu 
            820                 825             


<210>  1580
<211>  836
<212>  PRT
<213>  Homo sapiens

<400>  1580

Met Ala Gln Phe Tyr Tyr Lys Arg Asn Val Asn Ala Pro Tyr Arg Asp 
1               5                   10                  15      


Arg Ile Pro Leu Arg Ile Val Arg Ala Glu Ser Glu Leu Ser Pro Ser 
            20                  25                  30          


Glu Lys Ala Tyr Leu Asn Ala Val Glu Lys Gly Asp Tyr Ala Ser Val 
        35                  40                  45              


Lys Lys Ser Leu Glu Glu Ala Glu Ile Tyr Phe Lys Ile Asn Ile Asn 
    50                  55                  60                  


Cys Ile Asp Pro Leu Gly Arg Thr Ala Leu Leu Ile Ala Ile Glu Asn 
65                  70                  75                  80  


Glu Asn Leu Glu Leu Ile Glu Leu Leu Leu Ser Phe Asn Val Tyr Val 
                85                  90                  95      


Gly Asp Ala Leu Leu His Ala Ile Arg Lys Glu Val Val Gly Ala Val 
            100                 105                 110         


Glu Leu Leu Leu Asn His Lys Lys Pro Ser Gly Glu Lys Gln Val Pro 
        115                 120                 125             


Pro Ile Leu Leu Asp Lys Gln Phe Ser Glu Phe Thr Pro Asp Ile Thr 
    130                 135                 140                 


Pro Ile Ile Leu Ala Ala His Thr Asn Asn Tyr Glu Ile Ile Lys Leu 
145                 150                 155                 160 


Leu Val Gln Lys Gly Val Ser Val Pro Arg Pro His Glu Val Arg Cys 
                165                 170                 175     


Asn Cys Val Glu Cys Val Ser Ser Ser Asp Val Asp Ser Leu Arg His 
            180                 185                 190         


Ser Arg Ser Arg Leu Asn Ile Tyr Lys Ala Leu Ala Ser Pro Ser Leu 
        195                 200                 205             


Ile Ala Leu Ser Ser Glu Asp Pro Phe Leu Thr Ala Phe Gln Leu Ser 
    210                 215                 220                 


Trp Glu Leu Gln Glu Leu Ser Lys Val Glu Asn Glu Phe Lys Ser Glu 
225                 230                 235                 240 


Tyr Glu Glu Leu Ser Arg Gln Cys Lys Gln Phe Ala Lys Asp Leu Leu 
                245                 250                 255     


Asp Gln Thr Arg Ser Ser Arg Glu Leu Glu Ile Ile Leu Asn Tyr Arg 
            260                 265                 270         


Asp Asp Asn Ser Leu Ile Glu Glu Gln Ser Gly Asn Asp Leu Ala Arg 
        275                 280                 285             


Leu Lys Leu Ala Ile Lys Tyr Arg Gln Lys Glu Phe Val Ala Gln Pro 
    290                 295                 300                 


Asn Cys Gln Gln Leu Leu Ala Ser Arg Trp Tyr Asp Glu Phe Pro Gly 
305                 310                 315                 320 


Trp Arg Arg Arg His Trp Ala Val Lys Met Val Thr Cys Phe Ile Ile 
                325                 330                 335     


Gly Leu Leu Phe Pro Val Phe Ser Val Cys Tyr Leu Ile Ala Pro Lys 
            340                 345                 350         


Ser Pro Leu Gly Leu Phe Ile Arg Lys Pro Phe Ile Lys Phe Ile Cys 
        355                 360                 365             


His Thr Ala Ser Tyr Leu Thr Phe Leu Phe Leu Leu Leu Leu Ala Ser 
    370                 375                 380                 


Gln His Ile Asp Arg Ser Asp Leu Asn Arg Gln Gly Pro Pro Pro Thr 
385                 390                 395                 400 


Ile Val Glu Trp Met Ile Leu Pro Trp Val Leu Gly Phe Ile Trp Gly 
                405                 410                 415     


Glu Ile Lys Gln Met Trp Asp Gly Gly Leu Gln Asp Tyr Ile His Asp 
            420                 425                 430         


Trp Trp Asn Leu Met Asp Phe Val Met Asn Ser Leu Tyr Leu Ala Thr 
        435                 440                 445             


Ile Ser Leu Lys Ile Val Ala Phe Val Lys Tyr Ser Ala Leu Asn Pro 
    450                 455                 460                 


Arg Glu Ser Trp Asp Met Trp His Pro Thr Leu Val Ala Glu Ala Leu 
465                 470                 475                 480 


Phe Ala Ile Ala Asn Ile Phe Ser Ser Leu Arg Leu Ile Ser Leu Phe 
                485                 490                 495     


Thr Ala Asn Ser His Leu Gly Pro Leu Gln Ile Ser Leu Gly Arg Met 
            500                 505                 510         


Leu Leu Asp Ile Leu Lys Phe Leu Phe Ile Tyr Cys Leu Val Leu Leu 
        515                 520                 525             


Ala Phe Ala Asn Gly Leu Asn Gln Leu Tyr Phe Tyr Tyr Glu Glu Thr 
    530                 535                 540                 


Lys Gly Leu Thr Cys Lys Gly Ile Arg Cys Glu Lys Gln Asn Asn Ala 
545                 550                 555                 560 


Phe Ser Thr Leu Phe Glu Thr Leu Gln Ser Leu Phe Trp Ser Ile Phe 
                565                 570                 575     


Gly Leu Ile Asn Leu Tyr Val Thr Asn Val Lys Ala Gln His Glu Phe 
            580                 585                 590         


Thr Glu Phe Val Gly Ala Thr Met Phe Gly Thr Tyr Asn Val Ile Ser 
        595                 600                 605             


Leu Val Val Leu Leu Asn Met Leu Ile Ala Met Met Asn Asn Ser Tyr 
    610                 615                 620                 


Gln Leu Ile Ala Asp His Ala Asp Ile Glu Trp Lys Phe Ala Arg Thr 
625                 630                 635                 640 


Lys Leu Trp Met Ser Tyr Phe Glu Glu Gly Gly Thr Leu Pro Thr Pro 
                645                 650                 655     


Phe Asn Val Ile Pro Ser Pro Lys Ser Leu Trp Tyr Leu Ile Lys Trp 
            660                 665                 670         


Ile Trp Thr His Leu Cys Lys Lys Lys Met Arg Arg Lys Pro Glu Ser 
        675                 680                 685             


Phe Gly Thr Ile Gly Arg Arg Ala Ala Asp Asn Leu Arg Arg His His 
    690                 695                 700                 


Gln Tyr Gln Glu Val Met Arg Asn Leu Val Lys Arg Tyr Val Ala Ala 
705                 710                 715                 720 


Met Ile Arg Asp Ala Lys Thr Glu Glu Val Ala Arg Gln Gln Ala Ala 
                725                 730                 735     


Gly Pro Leu Glu Arg Asn Ile Gln Leu Glu Ser Arg Gly Leu Ala Ser 
            740                 745                 750         


Arg Gly Asp Leu Ser Ile Pro Gly Leu Ser Glu Gln Cys Val Leu Val 
        755                 760                 765             


Asp His Arg Glu Arg Asn Thr Asp Thr Leu Gly Leu Gln Val Gly Lys 
    770                 775                 780                 


Arg Val Cys Pro Phe Lys Ser Glu Lys Val Val Val Glu Asp Thr Val 
785                 790                 795                 800 


Pro Ile Ile Pro Lys Glu Lys His Ala Lys Glu Glu Asp Ser Ser Ile 
                805                 810                 815     


Asp Tyr Asp Leu Asn Leu Pro Asp Thr Val Thr His Glu Asp Tyr Val 
            820                 825                 830         


Thr Thr Arg Leu 
        835     


<210>  1581
<211>  804
<212>  PRT
<213>  Homo sapiens

<400>  1581

Met Ala Gln Phe Tyr Tyr Lys Arg Asn Val Asn Ala Pro Tyr Arg Asp 
1               5                   10                  15      


Arg Ile Pro Leu Arg Ile Val Arg Ala Glu Ser Glu Leu Ser Pro Ser 
            20                  25                  30          


Glu Lys Ala Tyr Leu Asn Ala Val Glu Lys Gly Asp Tyr Ala Ser Val 
        35                  40                  45              


Lys Lys Ser Leu Glu Glu Ala Glu Ile Tyr Phe Lys Ile Asn Ile Asn 
    50                  55                  60                  


Cys Ile Asp Pro Leu Gly Arg Thr Ala Leu Leu Ile Ala Ile Glu Asn 
65                  70                  75                  80  


Glu Asn Leu Glu Leu Ile Glu Leu Leu Leu Ser Phe Asn Val Tyr Val 
                85                  90                  95      


Gly Asp Ala Leu Leu His Ala Ile Arg Lys Glu Val Val Gly Ala Val 
            100                 105                 110         


Glu Leu Leu Leu Asn His Lys Lys Pro Ser Gly Glu Lys Gln Phe Val 
        115                 120                 125             


Ala Gln Pro Asn Cys Gln Gln Leu Leu Ala Ser Arg Trp Tyr Asp Glu 
    130                 135                 140                 


Phe Pro Gly Trp Arg Arg Arg His Trp Ala Val Lys Met Val Thr Cys 
145                 150                 155                 160 


Phe Ile Ile Gly Leu Leu Phe Pro Val Phe Ser Val Cys Tyr Leu Ile 
                165                 170                 175     


Ala Pro Lys Ser Pro Leu Gly Leu Phe Ile Arg Lys Pro Phe Ile Lys 
            180                 185                 190         


Phe Ile Cys His Thr Ala Ser Tyr Leu Thr Phe Leu Phe Leu Leu Leu 
        195                 200                 205             


Leu Ala Ser Gln His Ile Asp Arg Ser Asp Leu Asn Arg Gln Gly Pro 
    210                 215                 220                 


Pro Pro Thr Ile Val Glu Trp Met Ile Leu Pro Trp Val Leu Gly Phe 
225                 230                 235                 240 


Ile Trp Gly Glu Ile Lys Gln Met Trp Asp Gly Gly Leu Gln Asp Tyr 
                245                 250                 255     


Ile His Asp Trp Trp Asn Leu Met Asp Phe Val Met Asn Ser Leu Tyr 
            260                 265                 270         


Leu Ala Thr Ile Ser Leu Lys Ile Val Ala Phe Val Lys Tyr Ser Ala 
        275                 280                 285             


Leu Asn Pro Arg Glu Ser Trp Asp Met Trp His Pro Thr Leu Val Ala 
    290                 295                 300                 


Glu Ala Leu Phe Ala Ile Ala Asn Ile Phe Ser Ser Leu Arg Leu Ile 
305                 310                 315                 320 


Ser Leu Phe Thr Ala Asn Ser His Leu Gly Pro Leu Gln Ile Ser Leu 
                325                 330                 335     


Gly Arg Met Leu Leu Asp Ile Leu Lys Phe Leu Phe Ile Tyr Cys Leu 
            340                 345                 350         


Val Leu Leu Ala Phe Ala Asn Gly Leu Asn Gln Leu Tyr Phe Tyr Tyr 
        355                 360                 365             


Glu Glu Thr Lys Gly Leu Thr Cys Lys Gly Ile Arg Cys Glu Lys Gln 
    370                 375                 380                 


Asn Asn Ala Phe Ser Thr Leu Phe Glu Thr Leu Gln Ser Leu Phe Trp 
385                 390                 395                 400 


Ser Ile Phe Gly Leu Ile Asn Leu Tyr Val Thr Asn Val Lys Ala Gln 
                405                 410                 415     


His Glu Phe Thr Glu Phe Val Gly Ala Thr Met Phe Gly Thr Tyr Asn 
            420                 425                 430         


Val Ile Ser Leu Val Val Leu Leu Asn Met Leu Ile Ala Met Met Asn 
        435                 440                 445             


Asn Ser Tyr Gln Leu Ile Ala Asp His Ala Asp Ile Glu Trp Lys Phe 
    450                 455                 460                 


Ala Arg Thr Lys Leu Trp Met Ser Tyr Phe Glu Glu Gly Gly Thr Leu 
465                 470                 475                 480 


Pro Thr Pro Phe Asn Val Ile Pro Ser Pro Lys Ser Leu Trp Tyr Leu 
                485                 490                 495     


Ile Lys Trp Ile Trp Thr His Leu Cys Lys Lys Lys Met Arg Arg Lys 
            500                 505                 510         


Pro Glu Ser Phe Gly Thr Ile Gly Arg Arg Ala Ala Asp Asn Leu Arg 
        515                 520                 525             


Arg His His Gln Tyr Gln Glu Val Met Arg Asn Leu Val Lys Arg Tyr 
    530                 535                 540                 


Val Ala Ala Met Ile Arg Asp Ala Lys Thr Glu Glu Gly Leu Thr Glu 
545                 550                 555                 560 


Glu Asn Phe Lys Glu Leu Lys Gln Asp Ile Ser Ser Phe Arg Phe Glu 
                565                 570                 575     


Val Leu Gly Leu Leu Arg Gly Ser Lys Leu Ser Thr Ile Gln Ser Ala 
            580                 585                 590         


Asn Ala Ser Lys Glu Ser Ser Asn Ser Ala Asp Ser Asp Glu Lys Ser 
        595                 600                 605             


Asp Ser Glu Gly Asn Ser Lys Asp Lys Lys Lys Asn Phe Ser Leu Phe 
    610                 615                 620                 


Asp Leu Thr Thr Leu Ile His Pro Arg Ser Ala Ala Ile Ala Ser Glu 
625                 630                 635                 640 


Arg His Asn Ile Ser Asn Gly Ser Ala Leu Val Val Gln Glu Pro Pro 
                645                 650                 655     


Arg Glu Lys Gln Arg Lys Val Asn Phe Val Thr Asp Ile Lys Asn Phe 
            660                 665                 670         


Gly Leu Phe His Arg Arg Ser Lys Gln Asn Ala Ala Glu Gln Asn Ala 
        675                 680                 685             


Asn Gln Ile Phe Ser Val Ser Glu Glu Val Ala Arg Gln Gln Ala Ala 
    690                 695                 700                 


Gly Pro Leu Glu Arg Asn Ile Gln Leu Glu Ser Arg Gly Leu Ala Ser 
705                 710                 715                 720 


Arg Gly Asp Leu Ser Ile Pro Gly Leu Ser Glu Gln Cys Val Leu Val 
                725                 730                 735     


Asp His Arg Glu Arg Asn Thr Asp Thr Leu Gly Leu Gln Val Gly Lys 
            740                 745                 750         


Arg Val Cys Pro Phe Lys Ser Glu Lys Val Val Val Glu Asp Thr Val 
        755                 760                 765             


Pro Ile Ile Pro Lys Glu Lys His Ala Lys Glu Glu Asp Ser Ser Ile 
    770                 775                 780                 


Asp Tyr Asp Leu Asn Leu Pro Asp Thr Val Thr His Glu Asp Tyr Val 
785                 790                 795                 800 


Thr Thr Arg Leu 
                


<210>  1582
<211>  42
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<400>  1582

Asx Glu Thr Ala Ser Asx Cys Met Pro Leu Glu Xaa Ser Asx Asn Ile 
1               5                   10                  15      


Thr Met Ile Thr Cys His Asn Asp Arg Ile Ala Leu Ile Ser Phe Arg 
            20                  25                  30          


Met His Met Ser Ala Pro Ile Glu Asn Ser 
        35                  40          


<210>  1583
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  1583

Met Gly Arg Gly Tyr Ser Gly Ala Leu Gln Ala Arg Gly Gly Leu Glu 
1               5                   10                  15      


Glu Pro Leu Glu Arg Gly Leu Arg Gly Pro Ser Phe Thr Gln Ser Pro 
            20                  25                  30          


Leu His Gly Ala Ala Ala Ala Tyr Leu Ser Ala Gln Arg Asp Ala Ser 
        35                  40                  45              


Leu Pro Val Pro Gly Gln Arg Ser Asp Met Gln Lys Val Thr Leu Gly 
    50                  55                  60                  


Leu Leu Val Phe Leu Ala Gly Phe Pro Val Leu Asp Ala Asn Asp Leu 
65                  70                  75                  80  


Glu Asp Lys Asn Ser Pro Phe Tyr Tyr Asp Trp His Ser Leu Gln Val 
                85                  90                  95      


Gly Gly Leu Ile Cys Ala Gly Val Leu Cys Ala Met Gly Ile Ile Ile 
            100                 105                 110         


Val Met Ser Ala Lys Cys Lys Cys Lys Phe Gly Gln Lys Ser Gly His 
        115                 120                 125             


His Pro Gly Glu Thr Pro Pro Leu Ile Thr Pro Gly Ser Ala Gln Ser 
    130                 135                 140                 


<210>  1584
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  1584

Met Gln Lys Val Thr Leu Gly Leu Leu Val Phe Leu Ala Gly Phe Pro 
1               5                   10                  15      


Val Leu Asp Ala Asn Asp Leu Glu Asp Lys Asn Ser Pro Phe Tyr Tyr 
            20                  25                  30          


Asp Trp His Ser Leu Gln Val Gly Gly Leu Ile Cys Ala Gly Val Leu 
        35                  40                  45              


Cys Ala Met Gly Ile Ile Ile Val Met Ser Glu Trp Arg Ser Ser Gly 
    50                  55                  60                  


Glu Gln Ala Gly Arg Gly Trp Gly Ser Pro Pro Leu Thr Thr Gln Leu 
65                  70                  75                  80  


Ser Pro Thr Gly Ala Lys Cys Lys Cys Lys Phe Gly Gln Lys Ser Gly 
                85                  90                  95      


<210>  1585
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  1585

Met Gln Lys Val Thr Leu Gly Leu Leu Val Phe Leu Ala Gly Phe Pro 
1               5                   10                  15      


Val Leu Asp Ala Asn Asp Leu Glu Asp Lys Asn Ser Pro Phe Tyr Tyr 
            20                  25                  30          


Gly Glu Ser Pro Cys Pro Leu Ser Pro Pro His Asn Pro Thr Tyr Cys 
        35                  40                  45              


Leu Val Pro Arg Val Pro Ile Gln Gly Trp Gly Leu Thr 
    50                  55                  60      


<210>  1586
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  1586

Met Gln Lys Val Thr Leu Gly Leu Leu Val Phe Leu Ala Gly Phe Pro 
1               5                   10                  15      


Val Leu Asp Ala Asn Asp Leu Glu Asp Lys Asn Ser Pro Phe Tyr Tyr 
            20                  25                  30          


Gly Glu Ser Pro Cys Pro Leu Ser Pro Pro His Asn Pro Thr Tyr Cys 
        35                  40                  45              


Leu Val Pro Arg Val Pro Ile Gln Gly Trp Gly Leu Thr 
    50                  55                  60      


<210>  1587
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  1587

Met Gln Lys Val Thr Leu Gly Leu Leu Val Phe Leu Ala Gly Phe Pro 
1               5                   10                  15      


Val Leu Asp Ala Asn Asp Leu Glu Asp Lys Asn Ser Pro Phe Tyr Tyr 
            20                  25                  30          


Asp Trp His Ser Leu Gln Val Gly Gly Leu Ile Cys Ala Gly Val Leu 
        35                  40                  45              


Cys Ala Met Gly Ile Ile Ile Val Met Ser Ala Lys Cys Lys Cys Lys 
    50                  55                  60                  


Phe Gly Gln Lys Ser Gly His His Pro Gly Glu Thr Pro Pro Leu Ile 
65                  70                  75                  80  


Thr Pro Gly Ser Ala Gln Ser 
                85          


<210>  1588
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  1588

Met Gln Lys Val Thr Leu Gly Leu Leu Val Phe Leu Ala Gly Phe Pro 
1               5                   10                  15      


Val Leu Asp Ala Asn Asp Leu Glu Asp Lys Asn Ser Pro Phe Tyr Tyr 
            20                  25                  30          


Asp Trp His Ser Leu Gln Val Gly Gly Leu Ile Cys Ala Gly Val Leu 
        35                  40                  45              


Cys Ala Met Gly Ile Ile Ile Val Met Ser Glu Trp Arg Ser Ser Gly 
    50                  55                  60                  


Glu Gln Ala Gly Arg Gly Trp Gly Ser Pro Pro Leu Thr Thr Gln Leu 
65                  70                  75                  80  


Ser Pro Thr Gly Ala Lys Cys Lys Cys Lys Phe Gly Gln Lys Ser Gly 
                85                  90                  95      


His His Pro Gly Glu Thr Pro Pro Leu Ile Thr Pro Gly Ser Ala Gln 
            100                 105                 110         


Ser 
    


<210>  1589
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  1589

Met Gly Val Pro Arg Pro Gln Pro Trp Ala Leu Gly Leu Leu Leu Phe 
1               5                   10                  15      


Leu Leu Pro Gly Ser Leu Gly Ala Glu Ser His Leu Ser Leu Leu Tyr 
            20                  25                  30          


His Leu Thr Ala Val Ser Ser Pro Ala Pro Gly Thr Pro Ala Phe Trp 
        35                  40                  45              


Val Ser Gly Trp Leu Gly Pro Gln Gln Tyr Leu Ser Tyr Asn Ser Leu 
    50                  55                  60                  


Arg Gly Glu Ala Glu Pro Cys Gly Ala Trp Val Trp Glu Asn Gln Val 
65                  70                  75                  80  


Ser Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Arg Ile Lys Glu Lys 
                85                  90                  95      


Leu Phe Leu Glu Ala Phe Lys Ala Leu Gly Gly Lys Gly Pro Tyr Thr 
            100                 105                 110         


Leu Gln Gly Leu Leu Gly Cys Glu Leu Gly Pro Asp Asn Thr Ser Val 
        115                 120                 125             


Pro Thr Ala Lys Phe Ala Leu Asn Gly Glu Glu Phe Met Asn Phe Asp 
    130                 135                 140                 


Leu Lys Gln Gly Thr Trp Gly Gly Asp Trp Pro Glu Ala Leu Ala Ile 
145                 150                 155                 160 


Ser Gln Arg Trp Gln Gln Gln Asp Lys Ala Ala Asn Lys Glu Leu Thr 
                165                 170                 175     


Phe Leu Leu Phe Ser Cys Pro His Arg Leu Arg Glu His Leu Glu Arg 
            180                 185                 190         


Gly Arg Gly Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg Leu Lys 
        195                 200                 205             


Ala Arg Pro Ser Ser Pro Gly Phe Ser Val Leu Thr Cys Ser Ala Phe 
    210                 215                 220                 


Ser Phe Tyr Pro Pro Glu Leu Gln Leu Arg Phe Leu Arg Asn Gly Leu 
225                 230                 235                 240 


Ala Ala Gly Thr Gly Gln Gly Asp Phe Gly Pro Asn Ser Asp Gly Ser 
                245                 250                 255     


Phe His Ala Ser Ser Ser Leu Thr Val Lys Ser Gly Asp Glu His His 
            260                 265                 270         


Tyr Cys Cys Ile Val Gln His Ala Gly Leu Ala Gln Pro Leu Arg Val 
        275                 280                 285             


Glu Leu Glu Ser Pro Ala Lys Ser Ser Val Leu Val Val Gly Ile Val 
    290                 295                 300                 


Ile Gly Val Leu Leu Leu Thr Ala Ala Ala Val Gly Gly Ala Leu Leu 
305                 310                 315                 320 


Trp Arg Arg Met Arg Ser Gly Leu Pro Ala Pro Trp Ile Ser Leu Arg 
                325                 330                 335     


Gly Asp Asp Thr Gly Val Leu Leu Pro Thr Pro Gly Glu Ala Gln Asp 
            340                 345                 350         


Ala Asp Leu Lys Asp Val Asn Val Ile Pro Ala Thr Ala 
        355                 360                 365 


<210>  1590
<211>  483
<212>  PRT
<213>  Homo sapiens

<400>  1590

Met Ser Gly His Lys Cys Ser Tyr Pro Trp Asp Leu Gln Asp Arg Tyr 
1               5                   10                  15      


Ala Gln Asp Lys Ser Val Val Asn Lys Met Gln Gln Lys Tyr Trp Glu 
            20                  25                  30          


Thr Lys Gln Ala Phe Ile Lys Ala Thr Gly Lys Lys Glu Asp Glu His 
        35                  40                  45              


Val Val Ala Ser Asp Ala Asp Leu Asp Ala Lys Leu Glu Leu Phe His 
    50                  55                  60                  


Ser Ile Gln Arg Thr Cys Leu Asp Leu Ser Lys Ala Ile Val Leu Tyr 
65                  70                  75                  80  


Gln Lys Arg Ile Cys Phe Leu Ser Gln Glu Glu Asn Glu Leu Gly Lys 
                85                  90                  95      


Phe Leu Arg Ser Gln Gly Phe Gln Asp Lys Thr Arg Ala Gly Lys Met 
            100                 105                 110         


Met Gln Ala Thr Gly Lys Ala Leu Cys Phe Ser Ser Gln Gln Arg Leu 
        115                 120                 125             


Ala Leu Arg Asn Pro Leu Cys Arg Phe His Gln Glu Val Glu Thr Phe 
    130                 135                 140                 


Arg His Arg Ala Ile Ser Asp Thr Trp Leu Thr Val Asn Arg Met Glu 
145                 150                 155                 160 


Gln Cys Arg Thr Glu Tyr Arg Gly Ala Leu Leu Trp Met Lys Asp Val 
                165                 170                 175     


Ser Gln Glu Leu Asp Pro Asp Leu Tyr Lys Gln Met Glu Lys Phe Arg 
            180                 185                 190         


Lys Val Gln Thr Gln Val Arg Leu Ala Lys Lys Asn Phe Asp Lys Leu 
        195                 200                 205             


Lys Met Asp Val Cys Gln Lys Val Asp Leu Leu Gly Ala Ser Arg Cys 
    210                 215                 220                 


Asn Leu Leu Ser His Met Leu Ala Thr Tyr Gln Thr Thr Leu Leu His 
225                 230                 235                 240 


Phe Trp Glu Lys Thr Ser His Thr Met Ala Ala Ile His Glu Ser Phe 
                245                 250                 255     


Lys Gly Tyr Gln Pro Tyr Glu Phe Thr Thr Leu Lys Ser Leu Gln Asp 
            260                 265                 270         


Pro Met Lys Lys Leu Val Glu Lys Glu Glu Lys Lys Lys Ile Asn Gln 
        275                 280                 285             


Gln Glu Ser Thr Asp Ala Ala Val Gln Glu Pro Ser Gln Leu Ile Ser 
    290                 295                 300                 


Leu Glu Glu Glu Asn Gln Arg Lys Glu Ser Ser Ser Phe Lys Thr Glu 
305                 310                 315                 320 


Asp Gly Lys Ser Ile Leu Ser Ala Leu Asp Lys Gly Ser Thr His Thr 
                325                 330                 335     


Ala Cys Ser Gly Pro Ile Asp Glu Leu Leu Asp Met Lys Ser Glu Glu 
            340                 345                 350         


Gly Ala Cys Leu Gly Pro Val Ala Gly Thr Pro Glu Pro Glu Gly Ala 
        355                 360                 365             


Asp Lys Asp Asp Leu Leu Leu Leu Ser Glu Ile Phe Asn Ala Ser Ser 
    370                 375                 380                 


Leu Glu Glu Gly Glu Phe Ser Lys Glu Trp Ala Ala Val Phe Gly Asp 
385                 390                 395                 400 


Gly Gln Val Lys Glu Pro Val Pro Thr Met Ala Leu Gly Glu Pro Asp 
                405                 410                 415     


Pro Lys Ala Gln Thr Gly Ser Gly Phe Leu Pro Ser Gln Leu Leu Asp 
            420                 425                 430         


Gln Asn Met Lys Asp Leu Gln Ala Ser Leu Gln Glu Pro Ala Lys Ala 
        435                 440                 445             


Ala Ser Asp Leu Thr Ala Trp Phe Ser Leu Phe Ala Asp Leu Asp Pro 
    450                 455                 460                 


Leu Ser Asn Pro Asp Ala Val Gly Lys Thr Asp Lys Glu His Glu Leu 
465                 470                 475                 480 


Leu Asn Ala 
            


<210>  1591
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  1591

Met Pro Pro Lys Arg Asn Glu Lys Tyr Lys Leu Pro Ile Pro Phe Pro 
1               5                   10                  15      


Glu Gly Lys Val Leu Asp Asp Met Glu Gly Asn Gln Trp Val Leu Gly 
            20                  25                  30          


Lys Lys Ile Gly Ser Gly Gly Phe Gly Leu Ile Tyr Leu Ala Phe Pro 
        35                  40                  45              


Thr Asn Lys Pro Glu Lys Asp Ala Arg His Val Val Lys Val Glu Tyr 
    50                  55                  60                  


Gln Glu Asn Gly Pro Leu Phe Ser Glu Leu Lys Phe Tyr Gln Arg Val 
65                  70                  75                  80  


Ala Lys Lys Asp Cys Ile Lys Lys Trp Ile Glu Arg Lys Gln Leu Asp 
                85                  90                  95      


Tyr Leu Gly Ile Pro Leu Phe Tyr Gly Ser Gly Leu Thr Glu Phe Lys 
            100                 105                 110         


Gly Arg Ser Tyr Arg Phe Met Val Met Glu Arg Leu Gly Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Ser Gly Gln Asn Gly Thr Phe Lys Lys Ser Thr Val Leu 
    130                 135                 140                 


Gln Leu Gly Ile Arg Met Leu Asp Val Leu Glu Tyr Ile His Glu Asn 
145                 150                 155                 160 


Glu Tyr Val His Gly Asp Ile Lys Ala Ala Asn Leu Leu Leu Gly Tyr 
                165                 170                 175     


Lys Asn Pro Asp Gln Val Tyr Leu Ala Asp Tyr Gly Leu Ser Tyr Arg 
            180                 185                 190         


Tyr Cys Pro Asn Gly Asn His Lys Gln Tyr Gln Glu Asn Pro Arg Lys 
        195                 200                 205             


Gly His Asn Gly Thr Ile Glu Phe Thr Ser Leu Asp Ala His Lys Gly 
    210                 215                 220                 


Val Ala Leu Ser Arg Arg Ser Asp Val Glu Ile Leu Gly Tyr Cys Met 
225                 230                 235                 240 


Leu Arg Trp Leu Cys Gly Lys Leu Pro Trp Glu Gln Asn Leu Lys Asp 
                245                 250                 255     


Pro Val Ala Val Gln Thr Ala Lys Thr Asn Leu Leu Asp Glu Leu Pro 
            260                 265                 270         


Gln Ser Val Leu Lys Trp Ala Pro Ser Gly Ser Ser Cys Cys Glu Ile 
        275                 280                 285             


Ala Gln Phe Leu Val Cys Ala His Ser Leu Ala Tyr Asp Glu Lys Pro 
    290                 295                 300                 


Asn Tyr Gln Ala Leu Lys Lys Ile Leu Asn Pro His Gly Ile Pro Leu 
305                 310                 315                 320 


Gly Pro Leu Asp Phe Ser Thr Lys Gly Gln Ser Ile Asn Val His Thr 
                325                 330                 335     


Pro Asn Ser Gln Lys Val Asp Ser Gln Lys Ala Ala Thr Lys Gln Val 
            340                 345                 350         


Asn Lys Ala His Asn Arg Leu Ile Glu Lys Lys Val His Ser Glu Arg 
        355                 360                 365             


Ser Ala Glu Ser Cys Ala Thr Trp Lys Val Gln Lys Glu Glu Lys Leu 
    370                 375                 380                 


Ile Gly Leu Met Asn Asn Glu Ala Ala Gln Glu Ser Thr Arg Arg Arg 
385                 390                 395                 400 


Gln Lys Tyr Gln Glu Ser Gln Glu Pro Leu Asn Glu Val Asn Ser Phe 
                405                 410                 415     


Pro Gln Lys Ile Ser Tyr Thr Gln Phe Pro Asn Ser Phe Tyr Glu Pro 
            420                 425                 430         


His Gln Asp Phe Thr Ser Pro Asp Ile Phe Lys Lys Ser Arg Ser Pro 
        435                 440                 445             


Ser Trp Tyr Lys Tyr Thr Ser Thr Val Ser Thr Gly Ile Thr Asp Leu 
    450                 455                 460                 


Glu Ser Ser Thr Gly Leu Trp Pro Thr Ile Ser Gln Phe Thr Leu Ser 
465                 470                 475                 480 


Glu Glu Thr Asn Ala Asp Val Tyr Tyr Tyr Arg Ile Ile Ile Pro Val 
                485                 490                 495     


Leu Leu Met Leu Val Phe Leu Ala Leu Phe Phe Leu 
            500                 505             


<210>  1592
<211>  439
<212>  PRT
<213>  Homo sapiens

<400>  1592

Met Asp Asp Tyr Asp Lys Thr Cys Leu Glu Ser Ala Leu Val Gly Val 
1               5                   10                  15      


Cys Asn Ile Val Gln Gln Glu Trp Gly Gly Ala Ile Pro Cys Gln Val 
            20                  25                  30          


Val Leu Val Thr Asp Gly Cys Leu Gly Ile Gly Arg Gly Ser Leu Arg 
        35                  40                  45              


His Ser Leu Ala Thr Gln Asn Gln Arg Ser Glu Ser Asn Arg Phe Pro 
    50                  55                  60                  


Leu Pro Phe Pro Phe Pro Ser Lys Leu Tyr Ile Met Cys Met Ala Asn 
65                  70                  75                  80  


Leu Glu Glu Leu Gln Ser Thr Asp Ser Leu Glu Cys Leu Glu Arg Leu 
                85                  90                  95      


Ile Asp Leu Asn Asn Gly Glu Gly Gln Ile Phe Thr Ile Asp Gly Pro 
            100                 105                 110         


Leu Cys Leu Lys Asn Val Gln Ser Met Phe Gly Lys Leu Ile Asp Leu 
        115                 120                 125             


Ala Tyr Thr Pro Phe His Ala Val Leu Lys Cys Gly His Leu Thr Ala 
    130                 135                 140                 


Asp Val Gln Val Phe Pro Arg Pro Glu Pro Phe Val Val Asp Glu Glu 
145                 150                 155                 160 


Ile Asp Pro Ile Pro Lys Val Ile Asn Thr Asp Leu Glu Ile Val Gly 
                165                 170                 175     


Phe Ile Asp Ile Ala Asp Ile Ser Ser Pro Pro Val Leu Ser Arg His 
            180                 185                 190         


Leu Val Leu Pro Ile Ala Leu Asn Lys Glu Gly Asp Glu Val Gly Thr 
        195                 200                 205             


Gly Ile Thr Asp Asp Asn Glu Asp Glu Asn Ser Ala Asn Gln Ile Ala 
    210                 215                 220                 


Gly Lys Ile Pro Asn Phe Cys Val Leu Leu His Gly Ser Leu Lys Val 
225                 230                 235                 240 


Glu Gly Met Val Ala Ile Val Gln Leu Gly Pro Glu Trp His Gly Met 
                245                 250                 255     


Leu Tyr Ser Gln Ala Asp Ser Lys Lys Lys Ser Asn Leu Met Met Ser 
            260                 265                 270         


Leu Phe Glu Pro Gly Pro Glu Pro Leu Pro Trp Leu Gly Lys Met Ala 
        275                 280                 285             


Gln Leu Gly Pro Ile Ser Asp Ala Lys Glu Asn Pro Tyr Gly Glu Asp 
    290                 295                 300                 


Asp Asn Lys Ser Pro Phe Pro Leu Gln Pro Lys Asn Lys Arg Ser Tyr 
305                 310                 315                 320 


Ala Gln Asn Val Thr Val Trp Ile Lys Pro Ser Gly Leu Gln Thr Asp 
                325                 330                 335     


Val Gln Lys Ile Leu Arg Asn Ala Arg Lys Leu Pro Glu Lys Thr Gln 
            340                 345                 350         


Thr Phe Tyr Lys Glu Leu Asn Arg Leu Arg Lys Ala Ala Leu Ala Phe 
        355                 360                 365             


Gly Phe Leu Asp Leu Leu Lys Gly Val Ala Asp Met Leu Glu Arg Glu 
    370                 375                 380                 


Cys Thr Leu Leu Pro Glu Thr Ala His Pro Asp Ala Ala Phe Gln Leu 
385                 390                 395                 400 


Thr His Ala Ala Gln Gln Leu Lys Leu Ala Ser Thr Gly Thr Ser Glu 
                405                 410                 415     


Tyr Ala Ala Tyr Asp Gln Asn Ile Thr Pro Leu His Thr Asp Phe Ser 
            420                 425                 430         


Gly Ser Ser Thr Glu Arg Ile 
        435                 


<210>  1593
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  1593

Met Thr Leu Ile Glu Gly Val Gly Asp Glu Val Thr Val Leu Phe Ser 
1               5                   10                  15      


Val Leu Ala Cys Leu Leu Val Leu Ala Leu Ala Trp Val Ser Thr His 
            20                  25                  30          


Thr Ala Glu Gly Gly Asp Pro Leu Pro Gln Pro Ser Gly Thr Pro Thr 
        35                  40                  45              


Pro Ser Gln Pro Ser Ala Ala Met Ala Ala Thr Asp Ser Met Arg Gly 
    50                  55                  60                  


Glu Ala Pro Gly Ala Glu Thr Pro Ser Leu Arg His Arg Gly Gln Ala 
65                  70                  75                  80  


Ala Gln Pro Glu Pro Ser Thr Gly Phe Thr Ala Thr Pro Pro Ala Pro 
                85                  90                  95      


Asp Ser Pro Gln Glu Pro Leu Val Leu Arg Leu Lys Phe Leu Asn Asp 
            100                 105                 110         


Ser Glu Gln Val Ala Arg Ala Trp Pro His Asp Thr Ile Gly Ser Leu 
        115                 120                 125             


Lys Arg Thr Gln Phe Pro Gly Arg Glu Gln Gln Val Arg Leu Ile Tyr 
    130                 135                 140                 


Gln Gly Gln Leu Leu Gly Asp Asp Thr Gln Thr Leu Gly Ser Leu His 
145                 150                 155                 160 


Leu Pro Pro Asn Cys Val Leu His Cys His Val Ser Thr Arg Val Gly 
                165                 170                 175     


Pro Pro Asn Pro Pro Cys Pro Pro Gly Ser Glu Pro Gly Pro Ser Gly 
            180                 185                 190         


Leu Glu Ile Gly Ser Leu Leu Leu Pro Leu Leu Leu Leu Leu Leu Leu 
        195                 200                 205             


Leu Leu Trp Tyr Cys Gln Ile Gln Tyr Arg Pro Phe Phe Pro Leu Thr 
    210                 215                 220                 


Ala Thr Leu Gly Leu Ala Gly Phe Thr Leu Leu Leu Ser Leu Leu Ala 
225                 230                 235                 240 


Phe Ala Met Tyr Arg Pro 
                245     


<210>  1594
<211>  692
<212>  PRT
<213>  Homo sapiens

<400>  1594

Met Val Thr Thr Leu Gly Pro Lys Met Ala Ala Glu Trp Gly Gly Gly 
1               5                   10                  15      


Val Gly Tyr Ser Gly Ser Gly Pro Gly Arg Ser Arg Trp Arg Trp Ser 
            20                  25                  30          


Gly Ser Val Trp Val Arg Ser Val Leu Leu Leu Leu Gly Gly Leu Arg 
        35                  40                  45              


Ala Ser Ala Thr Ser Thr Pro Val Ser Leu Gly Ser Ser Pro Pro Cys 
    50                  55                  60                  


Arg His His Val Pro Ser Asp Thr Glu Val Ile Asn Lys Val His Leu 
65                  70                  75                  80  


Lys Ala Asn His Val Val Lys Arg Asp Val Asp Glu His Leu Arg Ile 
                85                  90                  95      


Lys Thr Val Tyr Asp Lys Ser Val Glu Glu Leu Leu Pro Glu Lys Lys 
            100                 105                 110         


Asn Leu Val Lys Asn Lys Leu Phe Pro Gln Ala Ile Ser Tyr Leu Glu 
        115                 120                 125             


Lys Thr Phe Gln Val Arg Arg Pro Ala Gly Thr Ile Leu Leu Ser Arg 
    130                 135                 140                 


Gln Cys Ala Thr Asn Gln Tyr Leu Arg Lys Glu Asn Asp Pro His Arg 
145                 150                 155                 160 


Tyr Cys Thr Gly Glu Cys Ala Ala His Thr Lys Cys Gly Pro Val Ile 
                165                 170                 175     


Val Pro Glu Glu His Leu Gln Gln Cys Arg Val Tyr Arg Gly Gly Lys 
            180                 185                 190         


Trp Pro His Gly Ala Val Gly Val Pro Asp Gln Glu Gly Ile Ser Asp 
        195                 200                 205             


Ala Asp Phe Val Leu Tyr Val Gly Ala Leu Ala Thr Glu Arg Cys Ser 
    210                 215                 220                 


His Glu Asn Ile Ile Ser Tyr Ala Ala Tyr Cys Gln Gln Glu Ala Asn 
225                 230                 235                 240 


Met Asp Arg Pro Ile Ala Gly Tyr Ala Asn Leu Cys Pro Asn Met Ile 
                245                 250                 255     


Ser Thr Gln Pro Gln Glu Phe Val Gly Met Leu Ser Thr Val Lys His 
            260                 265                 270         


Glu Val Ile His Ala Leu Gly Phe Ser Ala Gly Leu Phe Ala Phe Tyr 
        275                 280                 285             


His Asp Lys Asp Gly Asn Pro Leu Thr Ser Arg Phe Ala Asp Gly Leu 
    290                 295                 300                 


Pro Pro Phe Asn Tyr Ser Leu Gly Leu Tyr Gln Trp Ser Asp Lys Val 
305                 310                 315                 320 


Val Arg Lys Val Glu Arg Leu Trp Asp Val Arg Asp Asn Lys Ile Val 
                325                 330                 335     


Arg His Thr Val Tyr Leu Leu Val Thr Pro Arg Val Val Glu Glu Ala 
            340                 345                 350         


Arg Lys His Phe Asp Cys Pro Val Leu Glu Gly Met Glu Leu Glu Asn 
        355                 360                 365             


Gln Gly Gly Val Gly Thr Glu Leu Asn His Trp Glu Lys Arg Leu Leu 
    370                 375                 380                 


Glu Asn Glu Ala Met Thr Gly Ser His Thr Gln Asn Arg Val Leu Ser 
385                 390                 395                 400 


Arg Ile Thr Leu Ala Leu Met Glu Asp Thr Gly Trp Tyr Lys Ala Asn 
                405                 410                 415     


Tyr Ser Met Ala Glu Lys Leu Asp Trp Gly Arg Gly Met Gly Cys Asp 
            420                 425                 430         


Phe Val Arg Lys Ser Cys Lys Phe Trp Ile Asp Gln Gln Arg Gln Lys 
        435                 440                 445             


Arg Gln Met Leu Ser Pro Tyr Cys Asp Thr Leu Arg Ser Asn Pro Leu 
    450                 455                 460                 


Gln Leu Thr Cys Arg Gln Asp Gln Arg Ala Val Ala Val Cys Asn Leu 
465                 470                 475                 480 


Gln Lys Phe Pro Lys Pro Leu Pro Gln Glu Tyr Gln Tyr Phe Asp Glu 
                485                 490                 495     


Leu Ser Gly Ile Pro Ala Glu Asp Leu Pro Tyr Tyr Gly Gly Ser Val 
            500                 505                 510         


Glu Ile Ala Asp Tyr Cys Pro Phe Ser Gln Glu Phe Ser Trp His Leu 
        515                 520                 525             


Ser Gly Glu Tyr Gln Arg Ser Ser Asp Cys Arg Ile Leu Glu Asn Gln 
    530                 535                 540                 


Pro Glu Ile Phe Lys Asn Tyr Gly Ala Glu Lys Tyr Gly Pro His Ser 
545                 550                 555                 560 


Val Cys Leu Ile Gln Lys Ser Ala Phe Val Met Glu Lys Cys Glu Arg 
                565                 570                 575     


Lys Leu Ser Tyr Pro Asp Trp Gly Ser Gly Cys Tyr Gln Val Ser Cys 
            580                 585                 590         


Ser Pro Gln Gly Leu Lys Val Trp Val Gln Asp Thr Ser Tyr Leu Cys 
        595                 600                 605             


Ser Arg Ala Gly Gln Val Leu Pro Val Ser Ile Gln Met Asn Gly Trp 
    610                 615                 620                 


Ile His Asp Gly Asn Leu Leu Cys Pro Ser Cys Trp Asp Phe Cys Glu 
625                 630                 635                 640 


Leu Cys Pro Pro Glu Thr Asp Pro Pro Ala Thr Asn Leu Thr Arg Ala 
                645                 650                 655     


Leu Pro Leu Asp Leu Cys Ser Cys Ser Ser Ser Leu Val Val Thr Leu 
            660                 665                 670         


Trp Leu Leu Leu Gly Asn Leu Phe Pro Leu Leu Ala Gly Phe Leu Leu 
        675                 680                 685             


Cys Ile Trp His 
    690         


<210>  1595
<211>  1059
<212>  PRT
<213>  Homo sapiens

<400>  1595

Met Val Asp Val Leu Leu Leu Phe Ser Leu Cys Leu Leu Phe His Ile 
1               5                   10                  15      


Ser Arg Pro Asp Leu Ser His Asn Arg Leu Ser Phe Ile Lys Ala Ser 
            20                  25                  30          


Ser Met Ser His Leu Gln Ser Leu Arg Glu Val Lys Leu Asn Asn Asn 
        35                  40                  45              


Glu Leu Glu Thr Ile Pro Asn Leu Gly Pro Val Ser Ala Asn Ile Thr 
    50                  55                  60                  


Leu Leu Ser Leu Ala Gly Asn Arg Ile Val Glu Ile Leu Pro Glu His 
65                  70                  75                  80  


Leu Lys Glu Phe Gln Ser Leu Glu Thr Leu Asp Leu Ser Ser Asn Asn 
                85                  90                  95      


Ile Ser Glu Leu Gln Thr Ala Phe Pro Ala Leu Gln Leu Lys Tyr Leu 
            100                 105                 110         


Tyr Leu Asn Ser Asn Arg Val Thr Ser Met Glu Pro Gly Tyr Phe Asp 
        115                 120                 125             


Asn Leu Ala Asn Thr Leu Leu Val Leu Lys Leu Asn Arg Asn Arg Ile 
    130                 135                 140                 


Ser Ala Ile Pro Pro Lys Met Phe Lys Leu Pro Gln Leu Gln His Leu 
145                 150                 155                 160 


Glu Leu Asn Arg Asn Lys Ile Lys Asn Val Asp Gly Leu Thr Phe Gln 
                165                 170                 175     


Gly Leu Gly Ala Leu Lys Ser Leu Lys Met Gln Arg Asn Gly Val Thr 
            180                 185                 190         


Lys Leu Met Asp Gly Ala Phe Trp Gly Leu Ser Asn Met Glu Ile Leu 
        195                 200                 205             


Gln Leu Asp His Asn Asn Leu Thr Glu Ile Thr Lys Gly Trp Leu Tyr 
    210                 215                 220                 


Gly Leu Leu Met Leu Gln Glu Leu His Leu Ser Gln Asn Ala Ile Asn 
225                 230                 235                 240 


Arg Ile Ser Pro Asp Ala Trp Glu Phe Cys Gln Lys Leu Ser Glu Leu 
                245                 250                 255     


Asp Leu Thr Phe Asn His Leu Ser Arg Leu Asp Asp Ser Ser Phe Leu 
            260                 265                 270         


Gly Leu Ser Leu Leu Asn Thr Leu His Ile Gly Asn Asn Arg Val Ser 
        275                 280                 285             


Tyr Ile Ala Asp Cys Ala Phe Arg Gly Leu Ser Ser Leu Lys Thr Leu 
    290                 295                 300                 


Asp Leu Lys Asn Asn Glu Ile Ser Trp Thr Ile Glu Asp Met Asn Gly 
305                 310                 315                 320 


Ala Phe Ser Gly Leu Asp Lys Leu Arg Arg Leu Ile Leu Gln Gly Asn 
                325                 330                 335     


Arg Ile Arg Ser Ile Thr Lys Lys Ala Phe Thr Gly Leu Asp Ala Leu 
            340                 345                 350         


Glu His Leu Asp Leu Ser Asp Asn Ala Ile Met Ser Leu Gln Gly Asn 
        355                 360                 365             


Ala Phe Ser Gln Met Lys Lys Leu Gln Gln Leu His Leu Asn Thr Ser 
    370                 375                 380                 


Ser Leu Leu Cys Asp Cys Gln Leu Lys Trp Leu Pro Gln Trp Val Ala 
385                 390                 395                 400 


Glu Asn Asn Phe Gln Ser Phe Val Asn Ala Ser Cys Ala His Pro Gln 
                405                 410                 415     


Leu Leu Lys Gly Arg Ser Ile Phe Ala Val Ser Pro Asp Gly Phe Val 
            420                 425                 430         


Cys Asp Asp Phe Pro Lys Pro Gln Ile Thr Val Gln Pro Glu Thr Gln 
        435                 440                 445             


Ser Ala Ile Lys Gly Ser Asn Leu Ser Phe Ile Cys Ser Ala Ala Ser 
    450                 455                 460                 


Ser Ser Asp Ser Pro Met Thr Phe Ala Trp Lys Lys Asp Asn Glu Leu 
465                 470                 475                 480 


Leu His Asp Ala Glu Met Glu Asn Tyr Ala His Leu Arg Ala Gln Gly 
                485                 490                 495     


Gly Glu Val Met Glu Tyr Thr Thr Ile Leu Arg Leu Arg Glu Val Glu 
            500                 505                 510         


Phe Ala Ser Glu Gly Lys Tyr Gln Cys Val Ile Ser Asn His Phe Gly 
        515                 520                 525             


Ser Ser Tyr Ser Val Lys Ala Lys Leu Thr Val Asn Met Leu Pro Ser 
    530                 535                 540                 


Phe Thr Lys Thr Pro Met Asp Leu Thr Ile Arg Ala Gly Ala Met Ala 
545                 550                 555                 560 


Arg Leu Glu Cys Ala Ala Val Gly His Pro Ala Pro Gln Ile Ala Trp 
                565                 570                 575     


Gln Lys Asp Gly Gly Thr Asp Phe Pro Ala Ala Arg Glu Arg Arg Met 
            580                 585                 590         


His Val Met Pro Glu Asp Asp Val Phe Phe Ile Val Asp Val Lys Ile 
        595                 600                 605             


Glu Asp Ile Gly Val Tyr Ser Cys Thr Ala Gln Asn Ser Ala Gly Ser 
    610                 615                 620                 


Ile Ser Ala Asn Ala Thr Leu Thr Val Leu Glu Thr Pro Ser Phe Leu 
625                 630                 635                 640 


Arg Pro Leu Leu Asp Arg Thr Val Thr Lys Gly Glu Thr Ala Val Leu 
                645                 650                 655     


Gln Cys Ile Ala Gly Gly Ser Pro Pro Pro Lys Leu Asn Trp Thr Lys 
            660                 665                 670         


Asp Asp Ser Pro Leu Val Val Thr Glu Arg His Phe Phe Ala Ala Gly 
        675                 680                 685             


Asn Gln Leu Leu Ile Ile Val Asp Ser Asp Val Ser Asp Ala Gly Lys 
    690                 695                 700                 


Tyr Thr Cys Glu Met Ser Asn Thr Leu Gly Thr Glu Arg Gly Asn Val 
705                 710                 715                 720 


Arg Leu Ser Val Ile Pro Thr Pro Thr Cys Asp Ser Pro Gln Met Thr 
                725                 730                 735     


Ala Pro Ser Leu Asp Asp Asp Gly Trp Ala Thr Val Gly Val Val Ile 
            740                 745                 750         


Ile Ala Val Val Cys Cys Val Val Gly Thr Ser Leu Val Trp Val Val 
        755                 760                 765             


Ile Ile Tyr His Thr Arg Arg Arg Asn Glu Asp Cys Ser Ile Thr Asn 
    770                 775                 780                 


Thr Asp Glu Thr Asn Leu Pro Ala Asp Ile Pro Ser Tyr Leu Ser Ser 
785                 790                 795                 800 


Gln Gly Thr Leu Ala Asp Arg Gln Asp Gly Tyr Val Ser Ser Glu Ser 
                805                 810                 815     


Gly Ser His His Gln Phe Val Thr Ser Ser Gly Ala Gly Phe Phe Leu 
            820                 825                 830         


Pro Gln His Asp Ser Ser Gly Thr Cys His Ile Asp Asn Ser Ser Glu 
        835                 840                 845             


Ala Asp Val Glu Ala Ala Thr Asp Leu Phe Leu Cys Pro Phe Leu Gly 
    850                 855                 860                 


Ser Thr Gly Pro Met Tyr Leu Lys Gly Asn Val Tyr Gly Ser Asp Pro 
865                 870                 875                 880 


Phe Glu Thr Tyr His Thr Gly Cys Ser Pro Asp Pro Arg Thr Val Leu 
                885                 890                 895     


Met Asp His Tyr Glu Pro Ser Tyr Ile Lys Lys Lys Glu Cys Tyr Pro 
            900                 905                 910         


Cys Ser His Pro Ser Glu Glu Ser Cys Glu Arg Ser Phe Ser Asn Ile 
        915                 920                 925             


Ser Trp Pro Ser His Val Arg Lys Leu Leu Asn Thr Ser Tyr Ser His 
    930                 935                 940                 


Asn Glu Gly Pro Gly Met Lys Asn Leu Cys Leu Asn Lys Ser Ser Leu 
945                 950                 955                 960 


Asp Phe Ser Ala Asn Pro Glu Pro Ala Ser Val Ala Ser Ser Asn Ser 
                965                 970                 975     


Phe Met Gly Thr Phe Gly Lys Ala Leu Arg Arg Pro His Leu Asp Ala 
            980                 985                 990         


Tyr Ser Ser Phe Gly Gln Pro Ser  Asp Cys Gln Pro Arg  Ala Phe Tyr 
        995                 1000                 1005             


Leu Lys  Ala His Ser Ser Pro  Asp Leu Asp Ser Gly  Ser Glu Glu 
    1010                 1015                 1020             


Asp Gly  Lys Glu Arg Thr Asp  Phe Gln Glu Glu Asn  His Ile Cys 
    1025                 1030                 1035             


Thr Phe  Lys Gln Thr Leu Glu  Asn Tyr Arg Thr Pro  Asn Phe Gln 
    1040                 1045                 1050             


Ser Tyr  Asp Leu Asp Thr 
    1055                 


<210>  1596
<211>  792
<212>  PRT
<213>  Homo sapiens

<400>  1596

Met Ala Glu Ala His Gln Ala Val Gly Phe Arg Pro Ser Leu Thr Ser 
1               5                   10                  15      


Asp Gly Ala Glu Val Glu Leu Ser Ala Pro Val Leu Gln Glu Ile Tyr 
            20                  25                  30          


Leu Ser Gly Leu Arg Ser Trp Lys Arg His Leu Ser Arg Phe Trp Asn 
        35                  40                  45              


Asp Phe Leu Thr Gly Val Phe Pro Ala Ser Pro Leu Ser Trp Leu Phe 
    50                  55                  60                  


Leu Phe Ser Ala Ile Gln Leu Ala Trp Phe Leu Gln Leu Asp Pro Ser 
65                  70                  75                  80  


Leu Gly Leu Met Glu Lys Ile Lys Glu Leu Leu Pro Asp Trp Gly Gly 
                85                  90                  95      


Gln His His Gly Leu Arg Gly Val Leu Ala Ala Ala Leu Phe Ala Ser 
            100                 105                 110         


Cys Leu Trp Gly Ala Leu Ile Phe Thr Leu His Val Ala Leu Arg Leu 
        115                 120                 125             


Leu Leu Ser Tyr His Gly Trp Leu Leu Glu Pro His Gly Ala Met Ser 
    130                 135                 140                 


Ser Pro Thr Lys Thr Trp Leu Ala Leu Val Arg Ile Phe Ser Gly Arg 
145                 150                 155                 160 


His Pro Met Leu Phe Ser Tyr Gln Arg Ser Leu Pro Arg Gln Pro Val 
                165                 170                 175     


Pro Ser Val Gln Asp Thr Val Arg Lys Tyr Leu Glu Ser Val Arg Pro 
            180                 185                 190         


Ile Leu Ser Asp Glu Asp Phe Asp Trp Thr Ala Val Leu Ala Gln Glu 
        195                 200                 205             


Phe Leu Arg Leu Gln Ala Ser Leu Leu Gln Trp Tyr Leu Arg Leu Lys 
    210                 215                 220                 


Ser Trp Trp Ala Ser Asn Tyr Val Ser Asp Trp Trp Glu Glu Phe Val 
225                 230                 235                 240 


Tyr Leu Arg Ser Arg Asn Pro Leu Met Val Asn Ser Asn Tyr Tyr Met 
                245                 250                 255     


Met Ala Ala Arg Ala Gly Asn Ala Val His Ala Leu Leu Leu Tyr Arg 
            260                 265                 270         


His Arg Leu Asn Arg Gln Glu Ile Pro Pro Thr Leu Leu Met Gly Met 
        275                 280                 285             


Arg Pro Leu Cys Ser Ala Gln Tyr Glu Lys Ile Phe Asn Thr Thr Arg 
    290                 295                 300                 


Ile Pro Gly Val Gln Lys Asp Tyr Ile Arg His Leu His Asp Ser Gln 
305                 310                 315                 320 


His Val Ala Val Phe His Arg Gly Arg Phe Phe Arg Met Gly Thr His 
                325                 330                 335     


Ser Arg Asn Ser Leu Leu Ser Pro Arg Ala Leu Glu Gln Gln Phe Gln 
            340                 345                 350         


Arg Ile Leu Asp Asp Pro Ser Pro Ala Cys Pro His Glu Glu His Leu 
        355                 360                 365             


Ala Ala Leu Thr Ala Ala Pro Arg Gly Thr Trp Ala Gln Val Arg Thr 
    370                 375                 380                 


Ser Leu Lys Thr Gln Ala Ala Glu Ala Leu Glu Ala Val Glu Gly Ala 
385                 390                 395                 400 


Ala Phe Phe Val Ser Leu Asp Ala Glu Pro Ala Gly Leu Thr Arg Glu 
                405                 410                 415     


Asp Pro Ala Ala Ser Leu Asp Ala Tyr Ala His Ala Leu Leu Ala Gly 
            420                 425                 430         


Arg Gly His Asp Arg Trp Phe Asp Lys Ser Phe Thr Leu Ile Val Phe 
        435                 440                 445             


Ser Asn Gly Lys Leu Gly Leu Ser Val Glu His Ser Trp Ala Asp Cys 
    450                 455                 460                 


Pro Ile Ser Gly His Met Trp Glu Phe Thr Leu Ala Thr Glu Cys Phe 
465                 470                 475                 480 


Gln Leu Gly Tyr Ser Thr Asp Gly His Cys Lys Gly His Pro Asp Pro 
                485                 490                 495     


Thr Leu Pro Gln Pro Gln Arg Leu Gln Trp Asp Leu Pro Asp Gln Ile 
            500                 505                 510         


His Ser Ser Ile Ser Leu Ala Leu Arg Gly Ala Lys Ile Leu Ser Glu 
        515                 520                 525             


Asn Val Asp Cys His Val Val Pro Phe Ser Leu Phe Gly Lys Ser Phe 
    530                 535                 540                 


Ile Arg Arg Cys His Leu Ser Ser Asp Ser Phe Ile Gln Ile Ala Leu 
545                 550                 555                 560 


Gln Leu Ala His Phe Arg Asp Arg Gly Gln Phe Cys Leu Thr Tyr Glu 
                565                 570                 575     


Ser Ala Met Thr Arg Leu Phe Leu Glu Gly Arg Thr Glu Thr Val Arg 
            580                 585                 590         


Ser Cys Thr Arg Glu Ala Cys Asn Phe Val Arg Ala Met Glu Asp Lys 
        595                 600                 605             


Glu Lys Thr Asp Pro Gln Cys Leu Ala Leu Phe Arg Val Ala Val Asp 
    610                 615                 620                 


Lys His Gln Ala Leu Leu Lys Ala Ala Met Ser Gly Gln Gly Val Asp 
625                 630                 635                 640 


Arg His Leu Phe Ala Leu Tyr Ile Val Ser Arg Phe Leu His Leu Gln 
                645                 650                 655     


Ser Pro Phe Leu Thr Gln Val His Ser Glu Gln Trp Gln Leu Ser Thr 
            660                 665                 670         


Ser Gln Ile Pro Val Gln Gln Met His Leu Phe Asp Val His Asn Tyr 
        675                 680                 685             


Pro Asp Tyr Val Ser Ser Gly Gly Gly Phe Gly Pro Ala Asp Asp His 
    690                 695                 700                 


Gly Tyr Gly Val Ser Tyr Ile Phe Met Gly Asp Gly Met Ile Thr Phe 
705                 710                 715                 720 


His Ile Ser Ser Lys Lys Ser Ser Thr Lys Thr Asp Ser His Arg Leu 
                725                 730                 735     


Gly Gln His Ile Glu Asp Ala Leu Leu Asp Val Ala Ser Leu Phe Gln 
            740                 745                 750         


Ala Gly Gln His Phe Lys Arg Arg Phe Arg Gly Ser Gly Lys Glu Asn 
        755                 760                 765             


Ser Arg His Arg Cys Gly Phe Leu Ser Arg Gln Thr Gly Ala Ser Lys 
    770                 775                 780                 


Ala Ser Met Thr Ser Thr Asp Phe 
785                 790         


<210>  1597
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  1597

Met Asp Thr Leu Glu Glu Val Thr Trp Ala Asn Gly Ser Thr Ala Leu 
1               5                   10                  15      


Pro Pro Pro Leu Ala Pro Asn Ile Ser Val Pro His Arg Cys Leu Leu 
            20                  25                  30          


Leu Leu Tyr Glu Asp Ile Gly Thr Ser Arg Val Arg Tyr Trp Asp Leu 
        35                  40                  45              


Leu Leu Leu Ile Pro Asn Val Leu Phe Leu Ile Phe Leu Leu Trp Lys 
    50                  55                  60                  


Leu Pro Ser Ala Arg Ala Lys Ile Arg Ile Thr Ser Ser Pro Ile Phe 
65                  70                  75                  80  


Ile Thr Phe Tyr Ile Leu Val Phe Val Val Ala Leu Val Gly Ile Ala 
                85                  90                  95      


Arg Ala Val Val Ser Met Thr Val Ser Thr Ser Asn Ala Ala Thr Val 
            100                 105                 110         


Ala Asp Lys Ile Leu Trp Glu Ile Thr Arg Phe Phe Leu Leu Ala Ile 
        115                 120                 125             


Glu Leu Ser Val Ile Ile Leu Gly Leu Ala Phe Gly His Leu Glu Ser 
    130                 135                 140                 


Lys Ser Ser Ile Lys Arg Val Leu Ala Ile Thr Thr Val Leu Ser Leu 
145                 150                 155                 160 


Ala Tyr Ser Val Thr Gln Gly Thr Leu Glu Ile Leu Tyr Pro Asp Ala 
                165                 170                 175     


His Leu Ser Ala Glu Asp Phe Asn Ile Tyr Gly His Gly Gly Arg Gln 
            180                 185                 190         


Phe Trp Leu Val Ser Ser Cys Phe Phe Phe Leu Val Tyr Ser Leu Val 
        195                 200                 205             


Val Ile Leu Pro Lys Thr Pro Leu Lys Glu Arg Ile Ser Leu Pro Ser 
    210                 215                 220                 


Arg Arg Ser Phe Tyr Val Tyr Ala Gly Ile Leu Ala Leu Leu Asn Leu 
225                 230                 235                 240 


Leu Gln Gly Leu Gly Ser Val Leu Leu Cys Phe Asp Ile Ile Glu Gly 
                245                 250                 255     


Leu Cys Cys Val Asp Ala Thr Thr Phe Leu Tyr Phe Ser Phe Phe Ala 
            260                 265                 270         


Pro Leu Ile Tyr Val Ala Phe Leu Arg Gly Phe Phe Gly Ser Glu Pro 
        275                 280                 285             


Lys Ile Leu Phe Ser Tyr Lys Cys Gln Val Asp Glu Thr Glu Glu Pro 
    290                 295                 300                 


Asp Val His Leu Pro Gln Pro Tyr Ala Val Ala Arg Arg Glu Gly Leu 
305                 310                 315                 320 


Glu Ala Ala Gly Ala Ala Gly Ala Ser Ala Ala Ser Tyr Ser Ser Thr 
                325                 330                 335     


Gln Phe Asp Ser Ala Gly Gly Val Ala Tyr Leu Asp Asp Ile Ala Ser 
            340                 345                 350         


Met Pro Cys His Thr Gly Ser Ile Asn Ser Thr Asp Ser Glu Arg Trp 
        355                 360                 365             


Lys Ala Ile Asn Ala 
    370             


<210>  1598
<211>  1108
<212>  PRT
<213>  Homo sapiens

<400>  1598

Met Arg Ser Glu Gly Ala Ala Pro Gly Pro Ala Ala Pro Leu Cys Gly 
1               5                   10                  15      


Ala Leu Ser Leu Leu Leu Gly Ala Leu Leu Gly Lys Val Ile Glu Gly 
            20                  25                  30          


His Gly Val Thr Asp Asn Ile Gln Arg Phe Ser Ser Leu Pro Pro Tyr 
        35                  40                  45              


Leu Pro Val Ser Tyr His Ile Leu Arg Ala Glu Thr Ser Phe Phe Leu 
    50                  55                  60                  


Lys Glu Ala Asn Gln Asp Leu Leu Arg Asn Ser Ser Leu Gln Ala Arg 
65                  70                  75                  80  


Val Glu Ser Phe Phe Thr Tyr Lys Thr Arg Gln Pro Pro Val Leu Asn 
                85                  90                  95      


Ala Ser Tyr Gly Pro Phe Ser Val Glu Lys Val Val Pro Leu Asp Leu 
            100                 105                 110         


Met Leu Thr Ser Asn Phe Leu Gly Pro Thr Asn Lys Phe Ser Phe Asp 
        115                 120                 125             


Trp Lys Leu Lys Ala His Ile Leu Arg Asp Lys Val Tyr Leu Ser Arg 
    130                 135                 140                 


Pro Lys Val Gln Val Leu Phe His Ile Met Gly Arg Asp Trp Asp Asp 
145                 150                 155                 160 


His Gly Ala Gly Glu Lys Leu Pro Cys Leu Arg Val Phe Ala Phe Arg 
                165                 170                 175     


Glu Thr Arg Glu Val Arg Gly Ser Cys Arg Leu Lys Gly Asp Leu Gly 
            180                 185                 190         


Leu Cys Val Ala Glu Leu Glu Leu Leu Ser Ser Trp Phe Ser Ala Pro 
        195                 200                 205             


Thr Val Gly Ala Gly Arg Lys Lys Ser Met Asp Gln Pro Glu Gly Thr 
    210                 215                 220                 


Pro Val Glu Leu Tyr Tyr Thr Val His Pro Gly Asn Glu Arg Gly Asp 
225                 230                 235                 240 


Cys Ala Gly Gly Asp Phe Arg Lys Gly Asn Ala Ile Arg Pro Gly Lys 
                245                 250                 255     


Asp Gly Leu Glu Glu Thr Thr Ser His Leu Gln Arg Ile Gly Thr Val 
            260                 265                 270         


Gly Leu Tyr Arg Ala Gln Asp Ser Ala Gln Leu Ser Glu Leu Arg Leu 
        275                 280                 285             


Asp Gly Asn Val Val Ile Trp Leu Pro Ser Arg Pro Val Lys Gln Gly 
    290                 295                 300                 


Glu Val Val Thr Ala Tyr Val Thr Ile Ser Ser Asn Ser Ser Val Asp 
305                 310                 315                 320 


Leu Phe Ile Leu Arg Ala Lys Val Lys Lys Gly Val Asn Ile Leu Ser 
                325                 330                 335     


Ala Gln Thr Arg Glu Pro Arg Gln Trp Gly Val Lys Gln Glu Val Gly 
            340                 345                 350         


Ser Gly Gly Lys His Val Thr Ala Thr Val Ala Cys Gln Arg Leu Gly 
        355                 360                 365             


Pro Ser Pro Arg Asn Arg Ser Ser Ser Leu Phe Asn Glu Val Val Gln 
    370                 375                 380                 


Met Asn Phe Glu Ile Ala Ser Phe Ser Ser Leu Ser Gly Thr Gln Pro 
385                 390                 395                 400 


Ile Thr Trp Gln Val Glu Tyr Pro Arg Lys Gly Thr Thr Asp Ile Ala 
                405                 410                 415     


Val Ser Glu Ile Phe Val Ser Gln Lys Asp Leu Val Gly Ile Val Pro 
            420                 425                 430         


Leu Ala Met Asp Thr Glu Ile Leu Asn Thr Ala Val Leu Thr Gly Lys 
        435                 440                 445             


Thr Val Ala Met Pro Ile Lys Val Val Ser Val Glu Glu Asn Ser Ala 
    450                 455                 460                 


Val Met Asp Ile Ser Glu Ser Val Glu Cys Lys Ser Thr Asp Glu Asp 
465                 470                 475                 480 


Val Ile Lys Val Ser Glu Arg Cys Asp Tyr Ile Phe Val Asn Gly Lys 
                485                 490                 495     


Glu Ile Lys Gly Lys Met Asp Ala Val Val Asn Phe Thr Tyr Gln Tyr 
            500                 505                 510         


Leu Ser Ala Pro Leu Cys Val Thr Val Trp Val Pro Arg Leu Pro Leu 
        515                 520                 525             


Gln Ile Glu Val Ser Asp Thr Glu Leu Ser Gln Ile Lys Gly Trp Arg 
    530                 535                 540                 


Val Pro Ile Val Thr Asn Lys Arg Pro Thr Arg Glu Ser Glu Asp Glu 
545                 550                 555                 560 


Asp Glu Glu Glu Arg Arg Gly Arg Gly Cys Ala Leu Gln Tyr Gln His 
                565                 570                 575     


Ala Thr Val Arg Val Leu Thr Gln Phe Val Ser Glu Gly Ala Gly Pro 
            580                 585                 590         


Trp Gly Gln Pro Asn Tyr Leu Leu Ser Pro Asn Trp Gln Phe Asp Ile 
        595                 600                 605             


Thr His Leu Val Ala Asp Phe Met Lys Leu Glu Glu Pro His Val Ala 
    610                 615                 620                 


Thr Leu Gln Asp Ser Arg Val Leu Val Gly Arg Glu Val Gly Met Thr 
625                 630                 635                 640 


Thr Ile Gln Val Leu Ser Pro Leu Ser Asp Ser Ile Leu Ala Glu Lys 
                645                 650                 655     


Thr Ile Thr Val Leu Asp Asp Lys Val Ser Val Thr Asp Leu Ala Ile 
            660                 665                 670         


Gln Leu Val Ala Gly Leu Ser Val Ala Leu Tyr Pro Asn Ala Glu Asn 
        675                 680                 685             


Ser Lys Ala Val Thr Ala Val Val Thr Ala Glu Glu Val Leu Arg Thr 
    690                 695                 700                 


Pro Lys Gln Glu Ala Val Phe Ser Thr Trp Leu Gln Phe Ser Asp Gly 
705                 710                 715                 720 


Ser Val Thr Pro Leu Asp Ile Tyr Asp Thr Lys Asp Phe Ser Leu Ala 
                725                 730                 735     


Ala Thr Ser Gln Asp Glu Ala Val Val Ser Val Pro Gln Pro Arg Ser 
            740                 745                 750         


Pro Arg Trp Pro Val Val Val Ala Glu Gly Glu Gly Gln Gly Pro Leu 
        755                 760                 765             


Ile Arg Val Asp Met Thr Ile Ala Glu Ala Cys Gln Lys Ser Lys Arg 
    770                 775                 780                 


Lys Ser Ile Leu Ala Val Gly Val Gly Asn Val Arg Val Lys Phe Gly 
785                 790                 795                 800 


Gln Asn Asp Ala Asp Ser Ser Pro Gly Gly Asp Tyr Glu Glu Asp Glu 
                805                 810                 815     


Ile Lys Asn His Ala Ser Asp Arg Arg Gln Lys Gly Gln His His Glu 
            820                 825                 830         


Arg Thr Gly Gln Asp Gly His Leu Tyr Gly Ser Ser Pro Val Glu Arg 
        835                 840                 845             


Glu Glu Gly Ala Leu Arg Arg Ala Thr Thr Thr Ala Arg Ser Leu Leu 
    850                 855                 860                 


Asp Asn Lys Val Val Lys Asn Ser Arg Ala Asp Gly Gly Arg Leu Ala 
865                 870                 875                 880 


Gly Glu Gly Gln Leu Gln Asn Ile Pro Ile Asp Phe Thr Asn Phe Pro 
                885                 890                 895     


Ala His Val Asp Leu Pro Lys Ala Gly Ser Gly Leu Glu Glu Asn Asp 
            900                 905                 910         


Leu Val Gln Thr Pro Arg Gly Leu Ser Asp Leu Glu Ile Gly Met Tyr 
        915                 920                 925             


Ala Leu Leu Gly Val Phe Cys Leu Ala Ile Leu Val Phe Leu Ile Asn 
    930                 935                 940                 


Cys Ala Thr Phe Ala Leu Lys Tyr Arg His Lys Gln Val Pro Leu Glu 
945                 950                 955                 960 


Gly Gln Ala Ser Met Thr His Ser His Asp Trp Val Trp Leu Gly Asn 
                965                 970                 975     


Glu Ala Glu Leu Leu Glu Ser Met Gly Asp Ala Pro Pro Pro Gln Asp 
            980                 985                 990         


Glu His Thr Thr Ile Ile Asp Arg  Gly Pro Gly Ala Cys  Glu Glu Ser 
        995                 1000                 1005             


Asn His  Leu Leu Leu Asn Gly  Gly Ser His Lys His  Val Gln Ser 
    1010                 1015                 1020             


Gln Ile  His Arg Ser Ala Asp  Ser Gly Gly Arg Gln  Gly Arg Glu 
    1025                 1030                 1035             


Gln Lys  Gln Asp Pro Leu His  Ser Pro Thr Ser Lys  Arg Lys Lys 
    1040                 1045                 1050             


Val Lys  Phe Thr Thr Phe Thr  Thr Ile Pro Pro Asp  Asp Ser Cys 
    1055                 1060                 1065             


Pro Thr  Val Asn Ser Ile Val  Ser Ser Asn Asp Glu  Asp Ile Lys 
    1070                 1075                 1080             


Trp Val  Cys Gln Asp Val Ala  Val Gly Ala Pro Lys  Glu Leu Arg 
    1085                 1090                 1095             


Asn Tyr  Leu Glu Lys Leu Lys  Asp Lys Ala 
    1100                 1105             


<210>  1599
<211>  725
<212>  PRT
<213>  Homo sapiens

<400>  1599

Met Trp Gly Phe Leu Lys Arg Pro Val Val Val Thr Ala Asp Ile Asn 
1               5                   10                  15      


Leu Ser Leu Val Ala Leu Thr Gly Met Gly Leu Leu Ser Arg Leu Trp 
            20                  25                  30          


Arg Leu Thr Tyr Pro Arg Ala Val Val Phe Asp Glu Val Tyr Tyr Gly 
        35                  40                  45              


Gln Tyr Ile Ser Phe Tyr Met Lys Gln Ile Phe Phe Leu Asp Asp Ser 
    50                  55                  60                  


Gly Pro Pro Phe Gly His Met Val Leu Ala Leu Gly Gly Tyr Leu Gly 
65                  70                  75                  80  


Gly Phe Asp Gly Asn Phe Leu Trp Asn Arg Ile Gly Ala Glu Tyr Ser 
                85                  90                  95      


Ser Asn Val Pro Val Trp Ser Leu Arg Leu Leu Pro Ala Leu Ala Gly 
            100                 105                 110         


Ala Leu Ser Val Pro Met Ala Tyr Gln Ile Val Leu Glu Leu His Phe 
        115                 120                 125             


Ser His Cys Ala Ala Met Gly Ala Ala Leu Leu Met Leu Ile Glu Asn 
    130                 135                 140                 


Ala Leu Ile Thr Gln Ser Arg Leu Met Leu Leu Glu Ser Val Leu Ile 
145                 150                 155                 160 


Phe Phe Asn Leu Leu Ala Val Leu Ser Tyr Leu Lys Phe Phe Asn Cys 
                165                 170                 175     


Gln Lys His Ser Pro Phe Ser Leu Ser Trp Trp Phe Trp Leu Thr Leu 
            180                 185                 190         


Thr Gly Val Ala Cys Ser Cys Ala Val Gly Ile Lys Tyr Met Gly Val 
        195                 200                 205             


Phe Thr Tyr Val Leu Val Leu Gly Val Ala Ala Val His Ala Trp His 
    210                 215                 220                 


Leu Leu Gly Asp Gln Thr Leu Ser Asn Val Cys Val Phe Cys His Leu 
225                 230                 235                 240 


Leu Ala Arg Ala Val Ala Leu Leu Val Ile Pro Val Val Leu Tyr Leu 
                245                 250                 255     


Leu Phe Phe Tyr Val His Leu Ile Leu Val Phe Arg Ser Gly Pro His 
            260                 265                 270         


Asp Gln Ile Met Ser Ser Ala Phe Gln Ala Ser Leu Glu Gly Gly Leu 
        275                 280                 285             


Ala Arg Ile Thr Gln Gly Gln Pro Leu Glu Val Ala Phe Gly Ser Gln 
    290                 295                 300                 


Val Thr Leu Arg Asn Val Phe Gly Lys Pro Val Pro Cys Trp Leu His 
305                 310                 315                 320 


Ser His Gln Asp Thr Tyr Pro Met Ile Tyr Glu Asn Gly Arg Gly Ser 
                325                 330                 335     


Ser His Gln Gln Gln Val Thr Cys Tyr Pro Phe Lys Asp Val Asn Asn 
            340                 345                 350         


Trp Trp Ile Val Lys Asp Pro Arg Arg His Gln Leu Val Val Ser Ser 
        355                 360                 365             


Pro Pro Arg Pro Val Arg His Gly Asp Met Val Gln Leu Val His Gly 
    370                 375                 380                 


Met Thr Thr Arg Ser Leu Asn Thr His Asp Val Ala Ala Pro Leu Ser 
385                 390                 395                 400 


Pro His Ser Gln Glu Val Ser Cys Tyr Ile Asp Tyr Asn Ile Ser Met 
                405                 410                 415     


Pro Ala Gln Asn Leu Trp Arg Leu Glu Ile Val Asn Arg Gly Ser Asp 
            420                 425                 430         


Thr Asp Val Trp Lys Thr Ile Leu Ser Glu Val Arg Phe Val His Val 
        435                 440                 445             


Asn Thr Ser Ala Val Leu Lys Leu Ser Gly Ala His Leu Pro Asp Trp 
    450                 455                 460                 


Gly Tyr Arg Gln Leu Glu Ile Val Gly Glu Lys Leu Ser Arg Gly Tyr 
465                 470                 475                 480 


His Gly Ser Thr Val Trp Asn Val Glu Glu His Arg Tyr Gly Ala Ser 
                485                 490                 495     


Gln Glu Gln Arg Glu Arg Glu Arg Glu Leu His Ser Pro Ala Gln Val 
            500                 505                 510         


Asp Val Ser Arg Asn Leu Ser Phe Met Ala Arg Phe Ser Glu Leu Gln 
        515                 520                 525             


Trp Arg Met Leu Ala Leu Arg Ser Asp Asp Ser Glu His Lys Tyr Ser 
    530                 535                 540                 


Ser Ser Pro Leu Glu Trp Val Thr Leu Asp Thr Asn Ile Ala Tyr Trp 
545                 550                 555                 560 


Leu His Pro Arg Thr Ser Ala Gln Ile His Leu Leu Gly Asn Ile Val 
                565                 570                 575     


Ile Trp Val Ser Gly Ser Leu Ala Leu Ala Ile Tyr Ala Leu Leu Ser 
            580                 585                 590         


Leu Trp Tyr Leu Leu Arg Arg Arg Arg Asn Val His Asp Leu Pro Gln 
        595                 600                 605             


Asp Ala Trp Leu Arg Trp Val Leu Ala Gly Ala Leu Cys Ala Gly Gly 
    610                 615                 620                 


Trp Ala Val Asn Tyr Leu Pro Phe Phe Leu Met Glu Lys Thr Leu Phe 
625                 630                 635                 640 


Leu Tyr His Tyr Leu Pro Ala Leu Thr Phe Gln Ile Leu Leu Leu Pro 
                645                 650                 655     


Val Val Leu Gln His Ile Ser Asp His Leu Cys Arg Ser Gln Leu Gln 
            660                 665                 670         


Arg Ser Ile Phe Ser Ala Leu Val Val Ala Trp Tyr Ser Ser Ala Cys 
        675                 680                 685             


His Val Ser Asn Thr Leu Arg Pro Leu Thr Tyr Gly Asp Lys Ser Leu 
    690                 695                 700                 


Ser Pro His Glu Leu Lys Ala Leu Arg Trp Lys Asp Ser Trp Asp Ile 
705                 710                 715                 720 


Leu Ile Arg Lys His 
                725 


<210>  1600
<211>  608
<212>  PRT
<213>  Homo sapiens

<400>  1600

Met Ala Tyr Gln Ile Val Leu Glu Leu His Phe Ser His Cys Ala Ala 
1               5                   10                  15      


Met Gly Ala Ala Leu Leu Met Leu Ile Glu Asn Ala Leu Ile Thr Gln 
            20                  25                  30          


Ser Arg Leu Met Leu Leu Glu Ser Val Leu Ile Phe Phe Asn Leu Leu 
        35                  40                  45              


Ala Val Leu Ser Tyr Leu Lys Phe Phe Asn Cys Gln Lys His Ser Pro 
    50                  55                  60                  


Phe Ser Leu Ser Trp Trp Phe Trp Leu Thr Leu Thr Gly Val Ala Cys 
65                  70                  75                  80  


Ser Cys Ala Val Gly Ile Lys Tyr Met Gly Val Phe Thr Tyr Val Leu 
                85                  90                  95      


Val Leu Gly Val Ala Ala Val His Ala Trp His Leu Leu Gly Asp Gln 
            100                 105                 110         


Thr Leu Ser Asn Val Cys Val Phe Cys His Leu Leu Ala Arg Ala Val 
        115                 120                 125             


Ala Leu Leu Val Ile Pro Val Val Leu Tyr Leu Leu Phe Phe Tyr Val 
    130                 135                 140                 


His Leu Ile Leu Val Phe Arg Ser Gly Pro His Asp Gln Ile Met Ser 
145                 150                 155                 160 


Ser Ala Phe Gln Ala Ser Leu Glu Gly Gly Leu Ala Arg Ile Thr Gln 
                165                 170                 175     


Gly Gln Pro Leu Glu Val Ala Phe Gly Ser Gln Val Thr Leu Arg Asn 
            180                 185                 190         


Val Phe Gly Lys Pro Val Pro Cys Trp Leu His Ser His Gln Asp Thr 
        195                 200                 205             


Tyr Pro Met Ile Tyr Glu Asn Gly Arg Gly Ser Ser His Gln Gln Gln 
    210                 215                 220                 


Val Thr Cys Tyr Pro Phe Lys Asp Val Asn Asn Trp Trp Ile Val Lys 
225                 230                 235                 240 


Asp Pro Arg Arg His Gln Leu Val Val Ser Ser Pro Pro Arg Pro Val 
                245                 250                 255     


Arg His Gly Asp Met Val Gln Leu Val His Gly Met Thr Thr Arg Ser 
            260                 265                 270         


Leu Asn Thr His Asp Val Ala Ala Pro Leu Ser Pro His Ser Gln Glu 
        275                 280                 285             


Val Ser Cys Tyr Ile Asp Tyr Asn Ile Ser Met Pro Ala Gln Asn Leu 
    290                 295                 300                 


Trp Arg Leu Glu Ile Val Asn Arg Gly Ser Asp Thr Asp Val Trp Lys 
305                 310                 315                 320 


Thr Ile Leu Ser Glu Val Arg Phe Val His Val Asn Thr Ser Ala Val 
                325                 330                 335     


Leu Lys Leu Ser Gly Ala His Leu Pro Asp Trp Gly Tyr Arg Gln Leu 
            340                 345                 350         


Glu Ile Val Gly Glu Lys Leu Ser Arg Gly Tyr His Gly Ser Thr Val 
        355                 360                 365             


Trp Asn Val Glu Glu His Arg Tyr Gly Ala Ser Gln Glu Gln Arg Glu 
    370                 375                 380                 


Arg Glu Arg Glu Leu His Ser Pro Ala Gln Val Asp Val Ser Arg Asn 
385                 390                 395                 400 


Leu Ser Phe Met Ala Arg Phe Ser Glu Leu Gln Trp Arg Met Leu Ala 
                405                 410                 415     


Leu Arg Ser Asp Asp Ser Glu His Lys Tyr Ser Ser Ser Pro Leu Glu 
            420                 425                 430         


Trp Val Thr Leu Asp Thr Asn Ile Ala Tyr Trp Leu His Pro Arg Thr 
        435                 440                 445             


Ser Ala Gln Ile His Leu Leu Gly Asn Ile Val Ile Trp Val Ser Gly 
    450                 455                 460                 


Ser Leu Ala Leu Ala Ile Tyr Ala Leu Leu Ser Leu Trp Tyr Leu Leu 
465                 470                 475                 480 


Arg Arg Arg Arg Asn Val His Asp Leu Pro Gln Asp Ala Trp Leu Arg 
                485                 490                 495     


Trp Val Leu Ala Gly Ala Leu Cys Ala Gly Gly Trp Ala Val Asn Tyr 
            500                 505                 510         


Leu Pro Phe Phe Leu Met Glu Lys Thr Leu Phe Leu Tyr His Tyr Leu 
        515                 520                 525             


Pro Ala Leu Thr Phe Gln Ile Leu Leu Leu Pro Val Val Leu Gln His 
    530                 535                 540                 


Ile Ser Asp His Leu Cys Arg Ser Gln Leu Gln Arg Ser Ile Phe Ser 
545                 550                 555                 560 


Ala Leu Val Val Ala Trp Tyr Ser Ser Ala Cys His Val Ser Asn Thr 
                565                 570                 575     


Leu Arg Pro Leu Thr Tyr Gly Asp Lys Ser Leu Ser Pro His Glu Leu 
            580                 585                 590         


Lys Ala Leu Arg Trp Lys Asp Ser Trp Asp Ile Leu Ile Arg Lys His 
        595                 600                 605             


<210>  1601
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  1601

Met Met Ala Gln Ser Lys Ala Asn Gly Ser His Tyr Ala Leu Thr Ala 
1               5                   10                  15      


Ile Gly Leu Gly Met Leu Val Leu Gly Val Ile Met Ala Met Trp Asn 
            20                  25                  30          


Leu Val Pro Gly Phe Ser Ala Ala Glu Lys Pro Thr Ala Gln Gly Ser 
        35                  40                  45              


Asn Lys Thr Glu Val Gly Gly Gly Ile Leu Lys Ser Lys Thr Phe Ser 
    50                  55                  60                  


Val Ala Tyr Val Leu Val Gly Ala Gly Val Met Leu Leu Leu Leu Ser 
65                  70                  75                  80  


Ile Cys Leu Ser Ile Arg Asp Lys Arg Lys Gln Arg Gln Gly Glu Asp 
                85                  90                  95      


Leu Ala His Val Gln His Pro Thr Gly Ala Gly Pro His Ala Gln Glu 
            100                 105                 110         


Glu Asp Ser Gln Glu Glu Glu Glu Glu Asp Glu Glu Ala Ala Ser Arg 
        115                 120                 125             


Tyr Tyr Val Pro Ser Tyr Glu Glu Val Met Asn Thr Asn Tyr Ser Glu 
    130                 135                 140                 


Ala Arg Gly Glu Glu Gln Asn Pro Arg Leu Ser Ile Ser Leu Pro Ser 
145                 150                 155                 160 


Tyr Glu Ser Leu Thr Gly Leu Asp Glu Thr Thr Pro Thr Ser Thr Arg 
                165                 170                 175     


Ala Asp Val Glu Ala Ser Pro Gly Asn Pro Pro Asp Arg Gln Asn Ser 
            180                 185                 190         


Lys Leu Ala Lys Arg Leu Lys Pro Leu Lys Val Arg Arg Ile Lys Ser 
        195                 200                 205             


Glu Lys Leu His Leu Lys Asp Phe Arg Ile Asn Leu Pro Asp Lys Asn 
    210                 215                 220                 


Val Pro Pro Pro Ser Ile Glu Pro Leu Thr Pro Pro Pro Gln Tyr Asp 
225                 230                 235                 240 


Glu Val Gln Glu Lys Ala Pro Asp Thr Arg Pro Pro Asp 
                245                 250             


<210>  1602
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  1602

Met Met Ala Gln Ser Lys Ala Asn Gly Ser His Tyr Ala Leu Thr Ala 
1               5                   10                  15      


Ile Gly Leu Gly Met Leu Val Leu Gly Val Ile Met Ala Met Trp Asn 
            20                  25                  30          


Leu Val Pro Gly Phe Ser Ala Ala Glu Lys Pro Thr Ala Gln Gly Ser 
        35                  40                  45              


Asn Lys Thr Glu Val Gly Gly Gly Ile Leu Lys Ser Lys Thr Phe Ser 
    50                  55                  60                  


Val Ala Tyr Val Leu Val Gly Ala Gly Val Met Leu Leu Leu Leu Ser 
65                  70                  75                  80  


Ile Cys Leu Ser Ile Arg Asp Lys Arg Lys Gln Arg Gln Gly Glu Asp 
                85                  90                  95      


Leu Ala His Val Gln His Pro Thr Gly Ala Gly Pro His Ala Gln Glu 
            100                 105                 110         


Glu Asp Ser Gln Glu Glu Glu Glu Glu Asp Glu Glu Ala Ala Ser Arg 
        115                 120                 125             


Tyr Tyr Val Pro Ser Tyr Glu Glu Val Met Asn Thr Asn Tyr Ser Glu 
    130                 135                 140                 


Ala Arg Gly Glu Glu Gln Asn Pro Arg Leu Ser Ile Ser Leu Pro Ser 
145                 150                 155                 160 


Tyr Glu Ser Leu Thr Gly Leu Asp Glu Thr Thr Pro Thr Ser Thr Arg 
                165                 170                 175     


Ala Asp Val Glu Ala Ser Pro Gly Asn Pro Pro Asp Arg Gln Asn Ser 
            180                 185                 190         


Lys Leu Ala Lys Arg Leu Lys Pro Leu Lys Val Arg Arg Ile Lys Ser 
        195                 200                 205             


Glu Lys Leu His Leu Lys Asp Phe Arg Ile Asn Leu Pro Asp Lys Asn 
    210                 215                 220                 


Val Pro Pro Pro Ser Ile Glu Pro Leu Thr Pro Pro Pro Gln Tyr Asp 
225                 230                 235                 240 


Glu Val Gln Glu Lys Ala Pro Asp Thr Arg Pro Pro Asp 
                245                 250             


<210>  1603
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  1603

Met Met Ala Gln Ser Lys Ala Asn Gly Ser His Tyr Ala Leu Thr Ala 
1               5                   10                  15      


Ile Gly Leu Gly Met Leu Val Leu Gly Val Ile Met Ala Met Trp Asn 
            20                  25                  30          


Leu Val Pro Gly Phe Ser Ala Ala Glu Lys Pro Thr Ala Gln Gly Ser 
        35                  40                  45              


Asn Lys Thr Glu Val Gly Gly Gly Ile Leu Lys Ser Lys Thr Phe Ser 
    50                  55                  60                  


Val Ala Tyr Val Leu Val Gly Ala Gly Val Met Leu Leu Leu Leu Ser 
65                  70                  75                  80  


Ile Cys Leu Ser Ile Arg Asp Lys Arg Lys Gln Arg Gln Gly Glu Asp 
                85                  90                  95      


Leu Ala His Val Gln His Pro Thr Gly Ala Gly Pro His Ala Gln Glu 
            100                 105                 110         


Glu Asp Ser Gln Glu Glu Glu Glu Glu Asp Glu Glu Ala Ala Ser Arg 
        115                 120                 125             


Tyr Tyr Val Pro Ser Tyr Glu Glu Val Met Asn Thr Asn Tyr Ser Glu 
    130                 135                 140                 


Ala Arg Gly Glu Glu Gln Asn Pro Arg Leu Ser Ile Ser Leu Pro Ser 
145                 150                 155                 160 


Tyr Glu Ser Leu Thr Gly Leu Asp Glu Thr Thr Pro Thr Ser Thr Arg 
                165                 170                 175     


Ala Asp Val Glu Ala Ser Pro Gly Asn Pro Pro Asp Arg Gln Asn Ser 
            180                 185                 190         


Lys Leu Ala Lys Arg Leu Lys Pro Leu Lys Val Arg Arg Ile Lys Ser 
        195                 200                 205             


Glu Lys Leu His Leu Lys Asp Phe Arg Ile Asn Leu Pro Asp Lys Asn 
    210                 215                 220                 


Val Pro Pro Pro Ser Ile Glu Pro Leu Thr Pro Pro Pro Gln Tyr Asp 
225                 230                 235                 240 


Glu Val Gln Glu Lys Ala Pro Asp Thr Arg Pro Pro Asp 
                245                 250             


<210>  1604
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  1604

Met Asp Ile Ile Glu Thr Ala Lys Leu Glu Glu His Leu Glu Asn Gln 
1               5                   10                  15      


Pro Ser Asp Pro Thr Asn Thr Tyr Ala Arg Pro Ala Glu Pro Val Glu 
            20                  25                  30          


Glu Glu Asn Lys Asn Gly Asn Gly Lys Pro Lys Ser Leu Ser Ser Gly 
        35                  40                  45              


Leu Arg Lys Gly Thr Lys Lys Tyr Pro Asp Tyr Ile Gln Ile Ala Met 
    50                  55                  60                  


Pro Thr Glu Ser Arg Asn Lys Phe Pro Leu Glu Trp Trp Lys Thr Gly 
65                  70                  75                  80  


Ile Ala Phe Ile Tyr Ala Val Phe Asn Leu Val Leu Thr Thr Val Met 
                85                  90                  95      


Ile Thr Val Val His Glu Arg Val Pro Pro Lys Glu Leu Ser Pro Pro 
            100                 105                 110         


Leu Pro Asp Lys Phe Phe Asp Tyr Ile Asp Arg Val Lys Trp Ala Phe 
        115                 120                 125             


Ser Val Ser Glu Ile Asn Gly Ile Ile Leu Val Gly Leu Trp Ile Thr 
    130                 135                 140                 


Gln Trp Leu Phe Leu Arg Tyr Lys Ser Ile Val Gly Arg Arg Phe Cys 
145                 150                 155                 160 


Phe Ile Ile Gly Thr Leu Tyr Leu Tyr Arg Cys Ile Thr Met Tyr Val 
                165                 170                 175     


Thr Thr Leu Pro Val Pro Gly Met His Phe Gln Cys Ala Pro Lys Leu 
            180                 185                 190         


Asn Gly Asp Ser Gln Ala Lys Val Gln Arg Ile Leu Arg Leu Ile Ser 
        195                 200                 205             


Gly Gly Gly Leu Ser Ile Thr Gly Ser His Ile Leu Cys Gly Asp Phe 
    210                 215                 220                 


Leu Phe Ser Gly His Thr Val Thr Leu Thr Leu Thr Tyr Leu Phe Ile 
225                 230                 235                 240 


Lys Glu Tyr Ser Pro Arg His Phe Trp Trp Tyr His Leu Ile Cys Trp 
                245                 250                 255     


Leu Leu Ser Ala Ala Gly Ile Ile Cys Ile Leu Val Ala His Glu His 
            260                 265                 270         


Tyr Thr Ile Asp Val Ile Ile Ala Tyr Tyr Ile Thr Thr Arg Leu Phe 
        275                 280                 285             


Trp Trp Tyr His Ser Met Ala Asn Glu Lys Asn Leu Lys Val Ser Ser 
    290                 295                 300                 


Gln Thr Asn Phe Leu Ser Arg Ala Trp Trp Phe Pro Ile Phe Tyr Phe 
305                 310                 315                 320 


Phe Glu Lys Asn Val Gln Gly Ser Ile Pro Cys Cys Phe Ser Trp Pro 
                325                 330                 335     


Leu Ser Trp Pro Pro Gly Cys Phe Lys Ser Ser Cys Lys Lys Tyr Ser 
            340                 345                 350         


Arg Val Gln Lys Ile Gly Glu Asp Asn Glu Lys Ser Thr 
        355                 360                 365 


<210>  1605
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  1605

Met Asp Ile Ile Glu Thr Ala Lys Leu Glu Glu His Leu Glu Asn Gln 
1               5                   10                  15      


Pro Ser Asp Pro Thr Asn Thr Tyr Ala Arg Pro Ala Glu Pro Val Glu 
            20                  25                  30          


Glu Glu Asn Lys Asn Gly Asn Gly Lys Pro Lys Ser Leu Ser Ser Gly 
        35                  40                  45              


Leu Arg Lys Gly Thr Lys Lys Tyr Pro Asp Tyr Ile Gln Ile Ala Met 
    50                  55                  60                  


Pro Thr Glu Ser Arg Asn Lys Phe Pro Leu Glu Trp Trp Lys Thr Gly 
65                  70                  75                  80  


Ile Ala Phe Ile Tyr Ala Val Phe Asn Leu Val Leu Thr Thr Val Met 
                85                  90                  95      


Ile Thr Val Val His Glu Arg Val Pro Pro Lys Glu Leu Ser Pro Pro 
            100                 105                 110         


Leu Pro Asp Lys Phe Phe Asp Tyr Ile Asp Arg Val Lys Trp Ala Phe 
        115                 120                 125             


Ser Val Ser Glu Ile Asn Gly Ile Ile Leu Val Gly Leu Trp Ile Thr 
    130                 135                 140                 


Gln Trp Leu Phe Leu Arg Tyr Lys Ser Ile Val Gly Arg Arg Phe Cys 
145                 150                 155                 160 


Phe Ile Ile Gly Thr Leu Tyr Leu Tyr Arg Cys Ile Thr Met Tyr Val 
                165                 170                 175     


Thr Thr Leu Pro Val Pro Gly Met His Phe Gln Cys Ala Pro Lys Leu 
            180                 185                 190         


Asn Gly Asp Ser Gln Ala Lys Val Gln Arg Ile Leu Arg Leu Ile Ser 
        195                 200                 205             


Gly Gly Gly Leu Ser Ile Thr Gly Ser His Ile Leu Cys Gly Asp Phe 
    210                 215                 220                 


Leu Phe Ser Gly His Thr Val Thr Leu Thr Leu Thr Tyr Leu Phe Ile 
225                 230                 235                 240 


Lys Glu Tyr Ser Pro Arg His Phe Trp Trp Tyr His Leu Ile Cys Trp 
                245                 250                 255     


Leu Leu Ser Ala Ala Gly Ile Ile Cys Ile Leu Val Ala His Glu His 
            260                 265                 270         


Tyr Thr Ile Asp Val Ile Ile Ala Tyr Tyr Ile Thr Thr Arg Leu Phe 
        275                 280                 285             


Trp Trp Tyr His Ser Met Ala Asn Glu Lys Asn Leu Lys Val Ser Ser 
    290                 295                 300                 


Gln Thr Asn Phe Leu Ser Arg Ala Trp Trp Phe Pro Ile Phe Tyr Phe 
305                 310                 315                 320 


Phe Glu Lys Asn Val Gln Gly Ser Ile Pro Cys Cys Phe Ser Trp Pro 
                325                 330                 335     


Leu Ser Trp Pro Pro Gly Cys Phe Lys Ser Ser Cys Lys Lys Tyr Ser 
            340                 345                 350         


Arg Val Gln Lys Ile Gly Glu Asp Asn Glu Lys Ser Thr 
        355                 360                 365 


<210>  1606
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  1606

Met Ala Lys Gly Glu Gly Ala Glu Ser Gly Ser Ala Ala Gly Leu Leu 
1               5                   10                  15      


Pro Thr Ser Ile Leu Gln Ser Thr Glu Arg Pro Ala Gln Val Lys Lys 
            20                  25                  30          


Glu Pro Lys Lys Lys Lys Gln Gln Leu Ser Val Cys Asn Lys Leu Cys 
        35                  40                  45              


Tyr Ala Leu Gly Gly Ala Pro Tyr Gln Val Thr Gly Cys Ala Leu Gly 
    50                  55                  60                  


Phe Phe Leu Gln Ile Tyr Leu Leu Asp Val Ala Gln Lys Asp Glu Glu 
65                  70                  75                  80  


Val Val Phe Cys Phe Ser Ser Phe Gln Val Gly Pro Phe Ser Ala Ser 
                85                  90                  95      


Ile Ile Leu Phe Val Gly Arg Ala Trp Asp Ala Ile Thr Asp Pro Leu 
            100                 105                 110         


Val Gly Leu Cys Ile Ser Lys Ser Pro Trp Thr Cys Leu Gly Arg Leu 
        115                 120                 125             


Met Pro Trp Ile Ile Phe Ser Thr Pro Leu Ala Val Ile Ala Tyr Phe 
    130                 135                 140                 


Leu Ile Trp Phe Val Pro Asp Phe Pro His Gly Gln Thr Tyr Trp Tyr 
145                 150                 155                 160 


Leu Leu Phe Tyr Cys Leu Phe Glu Thr Met Val Thr Cys Phe His Val 
                165                 170                 175     


Pro Tyr Ser Ala Leu Thr Met Phe Ile Ser Thr Glu Gln Thr Glu Arg 
            180                 185                 190         


Asp Ser Ala Thr Ala Tyr Arg Met Thr Val Glu Val Leu Gly Thr Val 
        195                 200                 205             


Leu Gly Thr Ala Ile Gln Gly Gln Ile Val Gly Gln Ala Asp Thr Pro 
    210                 215                 220                 


Cys Phe Gln Asp Leu Asn Ser Ser Thr Val Ala Ser Gln Ser Ala Asn 
225                 230                 235                 240 


His Thr His Gly Thr Thr Ser His Arg Glu Thr Gln Lys Ala Tyr Leu 
                245                 250                 255     


Leu Ala Ala Gly Val Ile Val Cys Ile Tyr Ile Ile Cys Ala Val Ile 
            260                 265                 270         


Leu Ile Leu Gly Val Arg Glu Gln Arg Glu Pro Tyr Glu Ala Gln Gln 
        275                 280                 285             


Ser Glu Pro Ile Ala Tyr Phe Arg Gly Leu Arg Leu Val Met Ser His 
    290                 295                 300                 


Gly Pro Tyr Ile Lys Leu Ile Thr Gly Phe Leu Phe Thr Ser Leu Ala 
305                 310                 315                 320 


Phe Met Leu Val Glu Gly Asn Phe Val Leu Phe Cys Thr Tyr Thr Leu 
                325                 330                 335     


Gly Phe Arg Asn Glu Phe Gln Asn Leu Leu Leu Ala Ile Met Leu Ser 
            340                 345                 350         


Ala Thr Leu Thr Ile Pro Ile Trp Gln Trp Phe Leu Thr Arg Phe Gly 
        355                 360                 365             


Lys Lys Thr Ala Val Tyr Val Gly Ile Ser Ser Ala Val Pro Phe Leu 
    370                 375                 380                 


Ile Leu Val Ala Leu Met Glu Ser Asn Leu Ile Ile Thr Tyr Ala Val 
385                 390                 395                 400 


Ala Val Ala Ala Gly Ile Ser Val Ala Ala Ala Phe Leu Leu Pro Trp 
                405                 410                 415     


Ser Met Leu Pro Asp Val Ile Asp Asp Phe His Leu Lys Gln Pro His 
            420                 425                 430         


Phe His Gly Thr Glu Pro Ile Phe Phe Ser Phe Tyr Val Phe Phe Thr 
        435                 440                 445             


Lys Phe Ala Ser Gly Val Ser Leu Gly Ile Ser Thr Leu Ser Leu Asp 
    450                 455                 460                 


Phe Ala Gly Tyr Gln Thr Arg Gly Cys Ser Gln Pro Glu Arg Val Lys 
465                 470                 475                 480 


Phe Thr Leu Asn Met Leu Val Thr Met Ala Pro Ile Val Leu Ile Leu 
                485                 490                 495     


Leu Gly Leu Leu Leu Phe Lys Met Tyr Pro Ile Asp Glu Glu Arg Arg 
            500                 505                 510         


Arg Gln Asn Lys Lys Ala Leu Gln Ala Leu Arg Asp Glu Ala Ser Ser 
        515                 520                 525             


Ser Gly Cys Ser Glu Thr Asp Ser Thr Glu Leu Ala Ser Ile Leu 
    530                 535                 540             


<210>  1607
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  1607

Met Glu Thr Leu Gly Ala Leu Leu Val Leu Glu Phe Leu Leu Leu Ser 
1               5                   10                  15      


Pro Val Glu Ala Gln Gln Ala Thr Glu His Arg Leu Lys Pro Trp Leu 
            20                  25                  30          


Val Gly Leu Ala Ala Val Val Gly Phe Leu Phe Ile Val Tyr Leu Val 
        35                  40                  45              


Leu Leu Ala Asn Arg Leu Trp Cys Ser Lys Ala Arg Ala Glu Asp Glu 
    50                  55                  60                  


Glu Glu Thr Thr Phe Arg Met Glu Ser Asn Leu Tyr Gln Asp Gln Ser 
65                  70                  75                  80  


Glu Asp Lys Arg Glu Lys Lys Glu Ala Lys Glu Lys Glu Glu Lys Arg 
                85                  90                  95      


Lys Lys Glu Lys Lys Thr Ala Lys Glu Gly Glu Ser Asn Leu Gly Leu 
            100                 105                 110         


Asp Leu Glu Glu Lys Glu Pro Gly Asp His Glu Arg Ala Lys Ser Thr 
        115                 120                 125             


Val Met 
    130 


<210>  1608
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  1608

Met Arg Asn Ile Phe Lys Arg Asn Gln Glu Pro Ile Val Ala Pro Ala 
1               5                   10                  15      


Thr Thr Thr Ala Thr Met Pro Ile Gly Pro Val Asp Asn Ser Thr Glu 
            20                  25                  30          


Ser Gly Gly Ala Gly Glu Ser Gln Glu Asp Met Phe Ala Lys Leu Lys 
        35                  40                  45              


Glu Lys Leu Phe Asn Glu Ile Asn Lys Ile Pro Leu Pro Pro Trp Ala 
    50                  55                  60                  


Leu Ile Ala Ile Ala Val Val Ala Gly Leu Leu Leu Leu Thr Cys Cys 
65                  70                  75                  80  


Phe Cys Ile Cys Lys Lys Cys Cys Cys Lys Lys Lys Lys Asn Lys Lys 
                85                  90                  95      


Glu Lys Gly Lys Gly Met Lys Asn Ala Met Asn Met Lys Asp Met Lys 
            100                 105                 110         


Gly Gly Gln Asp Asp Asp Asp Ala Glu Thr Gly Leu Thr Glu Gly Glu 
        115                 120                 125             


Gly Glu Gly Glu Glu Glu Lys Glu Pro Glu Asn Leu Gly Lys Leu Gln 
    130                 135                 140                 


Phe Ser Leu Asp Tyr Asp Phe Gln Ala Asn Gln Leu Thr Val Gly Val 
145                 150                 155                 160 


Leu Gln Ala Ala Glu Leu Pro Ala Leu Asp Met Gly Gly Thr Ser Asp 
                165                 170                 175     


Pro Tyr Val Lys Val Phe Leu Leu Pro Asp Lys Lys Lys Lys Tyr Glu 
            180                 185                 190         


Thr Lys Val His Arg Lys Thr Leu Asn Pro Ala Phe Asn Glu Thr Phe 
        195                 200                 205             


Thr Phe Lys Val Pro Tyr Gln Glu Leu Gly Gly Lys Thr Leu Val Met 
    210                 215                 220                 


Ala Ile Tyr Asp Phe Asp Arg Phe Ser Lys His Asp Ile Ile Gly Glu 
225                 230                 235                 240 


Val Lys Val Pro Met Asn Thr Val Asp Leu Gly Gln Pro Ile Glu Glu 
                245                 250                 255     


Trp Arg Asp Leu Gln Gly Gly Glu Lys Glu Glu Pro Glu Lys Leu Gly 
            260                 265                 270         


Asp Ile Cys Thr Ser Leu Arg Tyr Val Pro Thr Ala Gly Lys Leu Thr 
        275                 280                 285             


Val Cys Ile Leu Glu Ala Lys Asn Leu Lys Lys Met Asp Val Gly Gly 
    290                 295                 300                 


Leu Ser Asp Pro Tyr Val Lys Ile His Leu Met Gln Asn Gly Lys Arg 
305                 310                 315                 320 


Leu Lys Lys Lys Lys Thr Thr Val Lys Lys Lys Thr Leu Asn Pro Tyr 
                325                 330                 335     


Phe Asn Glu Ser Phe Ser Phe Glu Ile Pro Phe Glu Gln Ile Gln Lys 
            340                 345                 350         


Val Gln Val Val Val Thr Val Leu Asp Tyr Asp Lys Leu Gly Lys Asn 
        355                 360                 365             


Glu Ala Ile Gly Lys Ile Phe Val Gly Ser Asn Ala Thr Gly Thr Glu 
    370                 375                 380                 


Leu Arg His Trp Ser Asp Met Leu Ala Asn Pro Arg Arg Pro Ile Ala 
385                 390                 395                 400 


Gln Trp His Ser Leu Lys Pro Glu Glu Glu Val Asp Ala Leu Leu Gly 
                405                 410                 415     


Lys Asn Lys 
            


<210>  1609
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  1609

Met Gly Phe Asp Val Leu Leu Asp Gln Val Gly Gly Met Gly Arg Phe 
1               5                   10                  15      


Gln Ile Cys Leu Ile Ala Phe Phe Cys Ile Thr Asn Ile Leu Leu Phe 
            20                  25                  30          


Pro Asn Ile Val Leu Glu Asn Phe Thr Ala Phe Thr Pro Ser His Arg 
        35                  40                  45              


Cys Trp Val Pro Leu Leu Asp Asn Asp Thr Val Ser Asp Asn Asp Thr 
    50                  55                  60                  


Gly Thr Leu Ser Lys Asp Asp Leu Leu Arg Ile Ser Ile Pro Leu Asp 
65                  70                  75                  80  


Ser Asn Leu Arg Pro Gln Lys Cys Gln Arg Phe Ile His Pro Gln Trp 
                85                  90                  95      


Gln Leu Leu His Leu Asn Gly Thr Phe Pro Asn Thr Asn Glu Pro Asp 
            100                 105                 110         


Thr Glu Pro Cys Val Asp Gly Trp Val Tyr Asp Arg Ser Ser Phe Leu 
        115                 120                 125             


Ser Thr Ile Val Thr Glu Trp Asp Leu Val Cys Glu Ser Gln Ser Leu 
    130                 135                 140                 


Lys Ser Met Val Gln Ser Leu Phe Met Ala Gly Ser Leu Leu Gly Gly 
145                 150                 155                 160 


Leu Ile Tyr Gly His Leu Ser Asp Arg Val Gly Arg Lys Ile Ile Cys 
                165                 170                 175     


Lys Leu Cys Phe Leu Gln Leu Ala Ile Ser Asn Thr Cys Ala Ala Phe 
            180                 185                 190         


Ala Pro Thr Phe Leu Val Tyr Cys Ile Leu Arg Phe Leu Ala Gly Phe 
        195                 200                 205             


Ser Thr Met Thr Ile Leu Gly Asn Thr Phe Ile Leu Ser Leu Glu Trp 
    210                 215                 220                 


Thr Leu Pro Arg Ser Arg Ser Met Thr Ile Met Val Leu Leu Cys Ser 
225                 230                 235                 240 


Tyr Ser Val Gly Gln Met Leu Leu Gly Gly Leu Ala Phe Ala Ile Gln 
                245                 250                 255     


Asp Trp His Ile Leu Gln Leu Thr Val Ser Thr Pro Ile Ile Val Leu 
            260                 265                 270         


Phe Leu Ser Ser Trp Lys Met Val Glu Ser Ala Arg Trp Leu Ile Ile 
        275                 280                 285             


Asn Asn Gln Leu Asp Glu Gly Leu Lys Glu Leu Arg Arg Val Ala His 
    290                 295                 300                 


Ile Asn Gly Lys Lys Asn Thr Glu Glu Thr Leu Thr Thr Glu Leu Val 
305                 310                 315                 320 


Arg Ser Thr Met Lys Lys Glu Leu Asp Ala Val Arg Ile Lys Thr Ser 
                325                 330                 335     


Ile Phe Ser Leu Phe Arg Ala Pro Lys Leu Arg Met Arg Val Phe Gly 
            340                 345                 350         


Leu Cys Phe Val Arg Phe Ala Ile Thr Val Pro Phe Tyr Gly Leu Ile 
        355                 360                 365             


Leu Asn Leu Gln His Leu Gly Ser Asn Val Ser Leu Phe Gln Ile Leu 
    370                 375                 380                 


Cys Gly Ala Val Thr Phe Thr Ala Arg Cys Val Ser Leu Leu Thr Leu 
385                 390                 395                 400 


Asn His Met Gly Arg Arg Ile Ser Gln Ile Leu Phe Thr Phe Pro Val 
                405                 410                 415     


Gly Leu Phe Ile Leu Val Asn Thr Phe Leu Pro Gln Glu Met Gln Ile 
            420                 425                 430         


Leu Arg Val Val Leu Ala Thr Leu Gly Ile Gly Ser Val Ser Ala Ala 
        435                 440                 445             


Ser Asn Ser Ala Ser Val His His Asn Glu Leu Val Pro Thr Ile Leu 
    450                 455                 460                 


Arg Ser Thr Val Ala Gly Ile Asn Ala Val Ser Gly Arg Thr Gly Ala 
465                 470                 475                 480 


Ala Leu Ala Pro Leu Leu Met Thr Leu Met Ala Tyr Ser Pro His Leu 
                485                 490                 495     


Pro Trp Ile Ser Tyr Gly Val Phe Pro Ile Leu Ala Val Pro Val Ile 
            500                 505                 510         


Leu Leu Leu Pro Glu Thr Arg Asp Leu Pro Leu Pro Asn Thr Ile Gln 
        515                 520                 525             


Asp Val Glu Asn Asp Arg Lys Asp Ser Arg Asn Ile Lys Gln Glu Asp 
    530                 535                 540                 


Thr Cys Met Lys Val Thr Gln Phe 
545                 550         


<210>  1610
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  1610

Met Glu Gly Ala Ala Leu Leu Arg Val Ser Val Leu Cys Ile Trp Met 
1               5                   10                  15      


Ser Ala Leu Phe Leu Gly Val Gly Val Arg Ala Glu Glu Ala Gly Ala 
            20                  25                  30          


Arg Val Gln Gln Asn Val Pro Ser Gly Thr Asp Thr Gly Asp Pro Gln 
        35                  40                  45              


Ser Lys Pro Leu Gly Asp Trp Ala Ala Gly Thr Met Asp Pro Glu Ser 
    50                  55                  60                  


Ser Ile Phe Ile Glu Asp Ala Ile Lys Tyr Phe Lys Glu Lys Val Ser 
65                  70                  75                  80  


Thr Gln Asn Leu Leu Leu Leu Leu Thr Asp Asn Glu Ala Trp Asn Gly 
                85                  90                  95      


Phe Val Ala Ala Ala Glu Leu Pro Arg Asn Glu Ala Asp Glu Leu Arg 
            100                 105                 110         


Lys Ala Leu Asp Asn Leu Ala Arg Gln Met Ile Met Lys Asp Lys Asn 
        115                 120                 125             


Trp His Asp Lys Gly Gln Gln Tyr Arg Asn Trp Phe Leu Lys Glu Phe 
    130                 135                 140                 


Pro Arg Leu Lys Ser Glu Leu Glu Asp Asn Ile Arg Arg Leu Arg Ala 
145                 150                 155                 160 


Leu Ala Asp Gly Val Gln Lys Val His Lys Gly Thr Thr Ile Ala Asn 
                165                 170                 175     


Val Val Ser Gly Ser Leu Ser Ile Ser Ser Gly Ile Leu Thr Leu Val 
            180                 185                 190         


Gly Met Gly Leu Ala Pro Phe Thr Glu Gly Gly Ser Leu Val Leu Leu 
        195                 200                 205             


Glu Pro Gly Met Glu Leu Gly Ile Thr Ala Ala Leu Thr Gly Ile Thr 
    210                 215                 220                 


Ser Ser Thr Met Asp Tyr Gly Lys Lys Trp Trp Thr Gln Ala Gln Ala 
225                 230                 235                 240 


His Asp Leu Val Ile Lys Ser Leu Asp Lys Leu Lys Glu Val Arg Glu 
                245                 250                 255     


Phe Leu Gly Glu Asn Ile Ser Asn Phe Leu Ser Leu Ala Gly Asn Thr 
            260                 265                 270         


Tyr Gln Leu Thr Arg Gly Ile Gly Lys Asp Ile Arg Ala Leu Arg Arg 
        275                 280                 285             


Ala Arg Ala Asn Leu Gln Ser Val Pro His Ala Ser Ala Ser Arg Pro 
    290                 295                 300                 


Arg Val Thr Glu Pro Ile Ser Ala Glu Ser Gly Glu Gln Val Glu Arg 
305                 310                 315                 320 


Val Asn Glu Pro Ser Ile Leu Glu Met Ser Arg Gly Val Lys Leu Thr 
                325                 330                 335     


Asp Val Ala Pro Val Ser Phe Phe Leu Val Leu Asp Val Val Tyr Leu 
            340                 345                 350         


Val Tyr Glu Ser Lys His Leu His Glu Gly Ala Lys Ser Glu Thr Ala 
        355                 360                 365             


Glu Glu Leu Lys Lys Val Ala Gln Glu Leu Glu Glu Lys Leu Asn Ile 
    370                 375                 380                 


Leu Asn Asn Asn Tyr Lys Ile Leu Gln Ala Asp Gln Glu Leu 
385                 390                 395             


<210>  1611
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  1611

Met Glu Gly Ala Ala Leu Leu Arg Val Ser Val Leu Cys Ile Trp Val 
1               5                   10                  15      


Gln Gln Asn Val Pro Ser Gly Thr Asp Thr Gly Asp Pro Gln Ser Lys 
            20                  25                  30          


Pro Leu Gly Asp Trp Ala Ala Gly Thr Met Asp Pro Glu Ser Ser Ile 
        35                  40                  45              


Phe Ile Glu Asp Ala Ile Lys Tyr Phe Lys Glu Lys Val Ser Thr Gln 
    50                  55                  60                  


Asn Leu Leu Leu Leu Leu Thr Asp Asn Glu Ala Trp Asn Gly Phe Val 
65                  70                  75                  80  


Ala Ala Ala Glu Leu Pro Arg Asn Glu Ala Asp Glu Leu Arg Lys Ala 
                85                  90                  95      


Leu Asp Asn Leu Ala Arg Gln Met Ile Met Lys Asp Lys Asn Trp His 
            100                 105                 110         


Asp Lys Gly Gln Gln Tyr Arg Asn Trp Phe Leu Lys Glu Phe Pro Arg 
        115                 120                 125             


Leu Lys Ser Glu Leu Glu Asp Asn Ile Arg Arg Leu Arg Ala Leu Ala 
    130                 135                 140                 


Asp Gly Val Gln Lys Val His Lys Gly Thr Thr Ile Ala Asn Val Val 
145                 150                 155                 160 


Ser Gly Ser Leu Ser Ile Ser Ser Gly Ile Leu Thr Leu Val Gly Met 
                165                 170                 175     


Gly Leu Ala Pro Phe Thr Glu Gly Gly Ser Leu Val Leu Leu Glu Pro 
            180                 185                 190         


Gly Met Glu Leu Gly Ile Thr Ala Ala Leu Thr Gly Ile Thr Ser Ser 
        195                 200                 205             


Thr Met Asp Tyr Gly Lys Lys Trp Trp Thr Gln Ala Gln Ala His Asp 
    210                 215                 220                 


Leu Val Ile Lys Ser Leu Asp Lys Leu Lys Glu Val Arg Glu Phe Leu 
225                 230                 235                 240 


Gly Glu Asn Ile Ser Asn Phe Leu Ser Leu Ala Gly Asn Thr Tyr Gln 
                245                 250                 255     


Leu Thr Arg Gly Ile Gly Lys Asp Ile Arg Ala Leu Arg Arg Ala Arg 
            260                 265                 270         


Ala Asn Leu Gln Ser Val Pro His Ala Ser Ala Ser Arg Pro Arg Val 
        275                 280                 285             


Thr Glu Pro Ile Ser Ala Glu Ser Gly Glu Gln Val Glu Arg Val Asn 
    290                 295                 300                 


Glu Pro Ser Ile Leu Glu Met Ser Arg Gly Val Lys Leu Thr Asp Val 
305                 310                 315                 320 


Ala Pro Val Ser Phe Phe Leu Val Leu Asp Val Val Tyr Leu Val Tyr 
                325                 330                 335     


Glu Ser Lys His Leu His Glu Gly Ala Lys Ser Glu Thr Ala Glu Glu 
            340                 345                 350         


Leu Lys Lys Val Ala Gln Glu Leu Glu Glu Lys Leu Asn Ile Leu Asn 
        355                 360                 365             


Asn Asn Tyr Lys Ile Leu Gln Ala Asp Gln Glu Leu 
    370                 375                 380 


<210>  1612
<211>  600
<212>  PRT
<213>  Homo sapiens

<400>  1612

Met Ala Ala Leu Ala Pro Val Gly Ser Pro Ala Ser Arg Gly Pro Arg 
1               5                   10                  15      


Leu Ala Ala Gly Leu Arg Leu Leu Pro Met Leu Gly Leu Leu Gln Leu 
            20                  25                  30          


Leu Ala Glu Pro Gly Leu Gly Arg Val His His Leu Ala Leu Lys Asp 
        35                  40                  45              


Asp Val Arg His Lys Val His Leu Asn Thr Phe Gly Phe Phe Lys Asp 
    50                  55                  60                  


Gly Tyr Met Val Val Asn Val Ser Ser Leu Ser Leu Asn Glu Pro Glu 
65                  70                  75                  80  


Asp Lys Asp Val Thr Ile Gly Phe Ser Leu Asp Arg Thr Lys Asn Asp 
                85                  90                  95      


Gly Phe Ser Ser Tyr Leu Asp Glu Asp Val Asn Tyr Cys Ile Leu Lys 
            100                 105                 110         


Lys Gln Ser Val Ser Val Thr Leu Leu Ile Leu Asp Ile Ser Arg Ser 
        115                 120                 125             


Glu Val Arg Val Lys Ser Pro Pro Glu Ala Gly Thr Gln Leu Pro Lys 
    130                 135                 140                 


Ile Ile Phe Ser Arg Asp Glu Lys Val Leu Gly Gln Ser Gln Glu Pro 
145                 150                 155                 160 


Asn Val Asn Pro Ala Ser Ala Gly Asn Gln Thr Gln Lys Thr Gln Asp 
                165                 170                 175     


Gly Gly Lys Ser Lys Arg Ser Thr Val Asp Ser Lys Ala Met Gly Glu 
            180                 185                 190         


Lys Ser Phe Ser Val His Asn Asn Gly Gly Ala Val Ser Phe Gln Phe 
        195                 200                 205             


Phe Phe Asn Ile Ser Thr Asp Asp Gln Glu Gly Leu Tyr Ser Leu Tyr 
    210                 215                 220                 


Phe His Lys Cys Leu Gly Lys Glu Leu Pro Ser Asp Lys Phe Thr Phe 
225                 230                 235                 240 


Ser Leu Asp Ile Glu Ile Thr Glu Lys Asn Pro Asp Ser Tyr Leu Ser 
                245                 250                 255     


Ala Gly Glu Ile Pro Leu Pro Lys Leu Tyr Ile Ser Met Ala Phe Phe 
            260                 265                 270         


Phe Phe Leu Ser Gly Thr Ile Trp Ile His Ile Leu Arg Lys Arg Arg 
        275                 280                 285             


Asn Asp Val Phe Lys Ile His Trp Leu Met Ala Ala Leu Pro Phe Thr 
    290                 295                 300                 


Lys Ser Leu Ser Leu Val Phe His Ala Ile Asp Tyr His Tyr Ile Ser 
305                 310                 315                 320 


Ser Gln Gly Phe Pro Ile Glu Gly Trp Ala Val Val Tyr Tyr Ile Thr 
                325                 330                 335     


His Leu Leu Lys Gly Ala Leu Leu Phe Ile Thr Ile Ala Leu Ile Gly 
            340                 345                 350         


Thr Gly Trp Ala Phe Ile Lys His Ile Leu Ser Asp Lys Asp Lys Lys 
        355                 360                 365             


Ile Phe Met Ile Val Ile Pro Leu Gln Val Leu Ala Asn Val Ala Tyr 
    370                 375                 380                 


Ile Ile Ile Glu Ser Thr Glu Glu Gly Thr Thr Glu Tyr Gly Leu Trp 
385                 390                 395                 400 


Lys Asp Ser Leu Phe Leu Val Asp Leu Leu Cys Cys Gly Ala Ile Leu 
                405                 410                 415     


Phe Pro Val Val Trp Ser Ile Arg His Leu Gln Glu Ala Ser Ala Thr 
            420                 425                 430         


Asp Gly Lys Gly Asp Ser Met Gly Pro Leu Gln Gln Arg Ala Asn Leu 
        435                 440                 445             


Arg Ala Gly Ser Arg Ile Glu Ser His His Phe Ala Gln Ala Asp Leu 
    450                 455                 460                 


Glu Leu Leu Ala Ser Ser Cys Pro Pro Ala Ser Val Ser Gln Arg Ala 
465                 470                 475                 480 


Gly Ile Thr Ala Ala Ile Asn Leu Ala Lys Leu Lys Leu Phe Arg His 
                485                 490                 495     


Tyr Tyr Val Leu Ile Val Cys Tyr Ile Tyr Phe Thr Arg Ile Ile Ala 
            500                 505                 510         


Phe Leu Leu Lys Leu Ala Val Pro Phe Gln Trp Lys Trp Leu Tyr Gln 
        515                 520                 525             


Leu Leu Asp Glu Thr Ala Thr Leu Val Phe Phe Val Leu Thr Gly Tyr 
    530                 535                 540                 


Lys Phe Arg Pro Ala Ser Asp Asn Pro Tyr Leu Gln Leu Ser Gln Glu 
545                 550                 555                 560 


Glu Glu Asp Leu Glu Met Glu Ser Val Val Thr Thr Ser Gly Val Met 
                565                 570                 575     


Glu Ser Met Lys Lys Val Lys Lys Val Thr Asn Gly Ser Val Glu Pro 
            580                 585                 590         


Gln Gly Glu Trp Glu Gly Ala Val 
        595                 600 


<210>  1613
<211>  571
<212>  PRT
<213>  Homo sapiens

<400>  1613

Met Ala Ala Leu Ala Pro Val Gly Ser Pro Ala Ser Arg Gly Pro Arg 
1               5                   10                  15      


Leu Ala Ala Gly Leu Arg Leu Leu Pro Met Leu Gly Leu Leu Gln Leu 
            20                  25                  30          


Leu Ala Glu Pro Gly Leu Gly Arg Val His His Leu Ala Leu Lys Asp 
        35                  40                  45              


Asp Val Arg His Lys Val His Leu Asn Thr Phe Gly Phe Phe Lys Asp 
    50                  55                  60                  


Gly Tyr Met Val Val Asn Val Ser Ser Leu Ser Leu Asn Glu Pro Glu 
65                  70                  75                  80  


Asp Lys Asp Val Thr Ile Gly Phe Ser Leu Asp Arg Thr Lys Asn Asp 
                85                  90                  95      


Gly Phe Ser Ser Tyr Leu Asp Glu Asp Val Asn Tyr Cys Ile Leu Lys 
            100                 105                 110         


Lys Gln Ser Val Ser Val Thr Leu Leu Ile Leu Asp Ile Ser Arg Ser 
        115                 120                 125             


Glu Val Arg Val Lys Ser Pro Pro Glu Ala Gly Thr Gln Leu Pro Lys 
    130                 135                 140                 


Ile Ile Phe Ser Arg Asp Glu Lys Val Leu Gly Gln Ser Gln Glu Pro 
145                 150                 155                 160 


Asn Val Asn Pro Ala Ser Ala Gly Asn Gln Thr Gln Lys Thr Gln Asp 
                165                 170                 175     


Gly Gly Lys Ser Lys Arg Ser Thr Val Asp Ser Lys Ala Met Gly Glu 
            180                 185                 190         


Lys Ser Phe Ser Val His Asn Asn Gly Gly Ala Val Ser Phe Gln Phe 
        195                 200                 205             


Phe Phe Asn Ile Ser Thr Asp Asp Gln Glu Gly Leu Tyr Ser Leu Tyr 
    210                 215                 220                 


Phe His Lys Cys Leu Gly Lys Glu Leu Pro Ser Asp Lys Phe Thr Phe 
225                 230                 235                 240 


Ser Leu Asp Ile Glu Ile Thr Glu Lys Asn Pro Asp Ser Tyr Leu Ser 
                245                 250                 255     


Ala Gly Glu Ile Pro Leu Pro Lys Leu Tyr Ile Ser Met Ala Phe Phe 
            260                 265                 270         


Phe Phe Leu Ser Gly Thr Ile Trp Ile His Ile Leu Arg Lys Arg Arg 
        275                 280                 285             


Asn Asp Val Phe Lys Ile His Trp Leu Met Ala Ala Leu Pro Phe Thr 
    290                 295                 300                 


Lys Ser Leu Ser Leu Val Phe His Ala Ile Asp Tyr His Tyr Ile Ser 
305                 310                 315                 320 


Ser Gln Gly Phe Pro Ile Glu Gly Trp Ala Val Val Tyr Tyr Ile Thr 
                325                 330                 335     


His Leu Leu Lys Gly Ala Leu Leu Phe Ile Thr Ile Ala Leu Ile Gly 
            340                 345                 350         


Thr Gly Trp Ala Phe Ile Lys His Ile Leu Ser Asp Lys Asp Lys Lys 
        355                 360                 365             


Ile Phe Met Ile Val Ile Pro Leu Gln Val Leu Ala Asn Val Ala Tyr 
    370                 375                 380                 


Ile Ile Ile Glu Ser Thr Glu Glu Gly Thr Thr Glu Tyr Gly Leu Trp 
385                 390                 395                 400 


Lys Asp Ser Leu Phe Leu Val Asp Leu Leu Cys Cys Gly Ala Ile Leu 
                405                 410                 415     


Phe Pro Val Val Trp Ser Ile Arg His Leu Gln Glu Ala Ser Ala Thr 
            420                 425                 430         


Asp Gly Lys Gly Asp Ser Met Gly Pro Leu Gln Gln Arg Ala Asn Leu 
        435                 440                 445             


Arg Ala Gly Ser Arg Ile Ala Ala Ile Asn Leu Ala Lys Leu Lys Leu 
    450                 455                 460                 


Phe Arg His Tyr Tyr Val Leu Ile Val Cys Tyr Ile Tyr Phe Thr Arg 
465                 470                 475                 480 


Ile Ile Ala Phe Leu Leu Lys Leu Ala Val Pro Phe Gln Trp Lys Trp 
                485                 490                 495     


Leu Tyr Gln Leu Leu Asp Glu Thr Ala Thr Leu Val Phe Phe Val Leu 
            500                 505                 510         


Thr Gly Tyr Lys Phe Arg Pro Ala Ser Asp Asn Pro Tyr Leu Gln Leu 
        515                 520                 525             


Ser Gln Glu Glu Glu Asp Leu Glu Met Glu Ser Val Val Thr Thr Ser 
    530                 535                 540                 


Gly Val Met Glu Ser Met Lys Lys Val Lys Lys Val Thr Asn Gly Ser 
545                 550                 555                 560 


Val Glu Pro Gln Gly Glu Trp Glu Gly Ala Val 
                565                 570     


<210>  1614
<211>  566
<212>  PRT
<213>  Homo sapiens

<400>  1614

Met Ser Pro Pro Gly Ser Ala Ala Gly Glu Ser Ala Ala Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Pro Gly Val Ser Glu Glu Leu Thr Ala Ala Ala 
            20                  25                  30          


Ala Ala Ala Ala Ala Asp Glu Gly Pro Ala Arg Glu Glu Gln Arg Pro 
        35                  40                  45              


Ile Gln Pro Ser Phe Thr Lys Ser Leu Cys Arg Glu Ser His Trp Lys 
    50                  55                  60                  


Cys Leu Leu Leu Ser Leu Leu Met Tyr Gly Cys Leu Gly Ala Val Ala 
65                  70                  75                  80  


Trp Cys His Val Thr Thr Val Thr Arg Leu Thr Phe Ser Ser Ala Tyr 
                85                  90                  95      


Gln Gly Asn Ser Leu Met Tyr His Asp Ser Pro Cys Ser Asn Gly Tyr 
            100                 105                 110         


Val Tyr Ile Pro Leu Ala Phe Leu Leu Met Leu Tyr Ala Val Tyr Leu 
        115                 120                 125             


Val Glu Cys Trp His Cys Gln Ala Arg His Glu Leu Gln His Arg Val 
    130                 135                 140                 


Asp Val Ser Ser Val Arg Glu Arg Val Gly Arg Met Gln Gln Ala Thr 
145                 150                 155                 160 


Pro Cys Ile Trp Trp Lys Ala Ile Ser Tyr His Tyr Val Arg Arg Thr 
                165                 170                 175     


Arg Gln Val Thr Arg Tyr Arg Asn Gly Asp Ala Tyr Thr Thr Thr Gln 
            180                 185                 190         


Val Tyr His Glu Arg Val Asn Thr His Val Ala Glu Ala Glu Phe Asp 
        195                 200                 205             


Tyr Ala Arg Cys Gly Val Arg Asp Val Ser Lys Thr Leu Val Gly Leu 
    210                 215                 220                 


Glu Gly Ala Pro Ala Thr Arg Leu Arg Phe Thr Lys Cys Phe Ser Phe 
225                 230                 235                 240 


Ala Ser Val Glu Ala Glu Asn Ala Tyr Leu Cys Gln Arg Ala Arg Phe 
                245                 250                 255     


Phe Ala Glu Asn Glu Gly Leu Asp Asp Tyr Met Glu Ala Arg Glu Gly 
            260                 265                 270         


Met His Leu Lys Asn Val Asp Phe Arg Glu Phe Met Val Ala Phe Pro 
        275                 280                 285             


Asp Pro Ala Arg Pro Pro Trp Tyr Ala Cys Ser Ser Ala Phe Trp Ala 
    290                 295                 300                 


Ala Ala Leu Leu Thr Leu Ser Trp Pro Leu Arg Val Leu Ala Glu Tyr 
305                 310                 315                 320 


Arg Thr Ala Tyr Ala His Tyr His Val Glu Lys Leu Phe Gly Leu Glu 
                325                 330                 335     


Gly Pro Gly Ser Ala Ser Ser Ala Gly Gly Gly Leu Ser Pro Ser Asp 
            340                 345                 350         


Glu Leu Leu Pro Pro Leu Thr His Arg Leu Pro Arg Val Asn Thr Val 
        355                 360                 365             


Asp Ser Thr Glu Leu Glu Trp His Ile Arg Ser Asn Gln Gln Leu Val 
    370                 375                 380                 


Pro Ser Tyr Ser Glu Ala Val Leu Met Asp Leu Ala Gly Leu Gly Thr 
385                 390                 395                 400 


Arg Cys Gly Gly Ala Gly Gly Gly Tyr Ala Pro Ser Cys Arg Tyr Gly 
                405                 410                 415     


Gly Val Gly Gly Pro Gly Ala Ala Gly Val Ala Pro Tyr Arg Arg Ser 
            420                 425                 430         


Cys Glu His Cys Gln Arg Ala Val Ser Ser Ser Ser Ile Phe Ser Arg 
        435                 440                 445             


Ser Ala Leu Ser Ile Cys Ala Ser Pro Arg Ala Gly Pro Gly Pro Gly 
    450                 455                 460                 


Gly Gly Ala Gly Cys Gly Gly Ser Arg Phe Ser Leu Gly Arg Leu Tyr 
465                 470                 475                 480 


Gly Ser Arg Arg Ser Cys Leu Trp Arg Ser Arg Ser Gly Ser Val Asn 
                485                 490                 495     


Glu Ala Ser Cys Pro Thr Glu Gln Thr Arg Leu Ser Ser Gln Ala Ser 
            500                 505                 510         


Met Gly Asp Asp Glu Asp Asp Asp Glu Glu Glu Ala Gly Pro Pro Pro 
        515                 520                 525             


Pro Tyr His Asp Ala Leu Tyr Phe Pro Val Leu Ile Val His Arg Gln 
    530                 535                 540                 


Glu Gly Cys Leu Gly His Ser His Arg Pro Leu His Arg His Gly Ser 
545                 550                 555                 560 


Cys Val Glu Thr Ser Leu 
                565     


<210>  1615
<211>  1076
<212>  PRT
<213>  Homo sapiens

<400>  1615

Met Ser Ser Ala Glu Ile Ile Gly Ser Thr Asn Leu Ile Ile Leu Leu 
1               5                   10                  15      


Glu Asp Glu Val Phe Ala Asp Phe Phe Asn Thr Phe Leu Ser Leu Pro 
            20                  25                  30          


Val Phe Gly Gln Thr Pro Phe Tyr Thr Val Glu Asn Ser Gln Trp Ser 
        35                  40                  45              


Leu Trp Pro Glu Ile Pro Cys Asn Leu Ile Ala Lys Tyr Lys Gly Leu 
    50                  55                  60                  


Leu Thr Trp Leu Glu Lys Cys Arg Leu Pro Phe Phe Cys Lys Thr Asn 
65                  70                  75                  80  


Leu Cys Phe His Tyr Ile Leu Cys Gln Glu Phe Ile Ser Phe Ile Lys 
                85                  90                  95      


Ser Pro Glu Gly Gly Glu Glu Leu Val Asp Phe Trp Ile Leu Ala Glu 
            100                 105                 110         


Asn Ile Leu Ser Ile Asp Glu Met Asp Leu Glu Val Arg Asp Tyr Tyr 
        115                 120                 125             


Leu Ser Leu Leu Leu Met Leu Arg Ala Thr His Leu Gln Glu Gly Ser 
    130                 135                 140                 


Arg Val Val Thr Leu Cys Asn Met Asn Ile Lys Ser Leu Leu Asn Leu 
145                 150                 155                 160 


Ser Ile Trp His Pro Asn Gln Ser Thr Thr Arg Arg Glu Ile Leu Ser 
                165                 170                 175     


His Met Gln Lys Val Ala Leu Phe Lys Leu Gln Ser Tyr Trp Leu Pro 
            180                 185                 190         


Asn Phe Tyr Thr His Thr Lys Met Thr Met Ala Lys Glu Glu Ala Cys 
        195                 200                 205             


His Gly Leu Met Gln Glu Tyr Glu Thr Arg Leu Tyr Ser Val Cys Tyr 
    210                 215                 220                 


Thr His Ile Gly Gly Leu Pro Leu Asn Met Ser Ile Lys Lys Cys His 
225                 230                 235                 240 


His Phe Gln Lys Arg Tyr Ser Ser Arg Lys Ala Lys Arg Lys Met Trp 
                245                 250                 255     


Gln Leu Val Asp Pro Asp Ser Trp Ser Leu Glu Met Asp Leu Lys Pro 
            260                 265                 270         


Asp Ala Ile Gly Met Pro Leu Gln Glu Thr Cys Pro Gln Glu Lys Val 
        275                 280                 285             


Val Ile Gln Met Pro Ser Leu Lys Met Ala Ser Ser Lys Glu Thr Arg 
    290                 295                 300                 


Ile Ser Ser Leu Glu Lys Asp Met His Tyr Ala Lys Ile Ser Ser Met 
305                 310                 315                 320 


Glu Asn Lys Ala Lys Ser His Leu His Met Glu Ala Pro Phe Glu Thr 
                325                 330                 335     


Lys Val Ser Thr His Leu Arg Thr Val Ile Pro Ile Val Asn His Ser 
            340                 345                 350         


Ser Lys Met Thr Ile Gln Lys Ala Ile Lys Gln Ser Phe Ser Leu Gly 
        355                 360                 365             


Tyr Ile His Leu Ala Leu Cys Ala Asp Ala Cys Ala Gly Asn Pro Phe 
    370                 375                 380                 


Arg Asp His Leu Lys Lys Leu Asn Leu Lys Val Glu Ile Gln Leu Leu 
385                 390                 395                 400 


Asp Leu Trp Gln Asp Leu Gln His Phe Leu Ser Val Leu Leu Asn Asn 
                405                 410                 415     


Lys Lys Asn Gly Asn Ala Ile Phe Arg His Leu Leu Gly Asp Arg Ile 
            420                 425                 430         


Cys Glu Leu Tyr Leu Asn Glu Gln Ile Gly Pro Cys Leu Pro Leu Lys 
        435                 440                 445             


Ser Gln Thr Ile Gln Gly Leu Lys Glu Leu Leu Pro Ser Gly Asp Val 
    450                 455                 460                 


Ile Pro Trp Ile Pro Lys Ala Gln Lys Glu Ile Cys Lys Met Leu Ser 
465                 470                 475                 480 


Pro Trp Tyr Asp Glu Phe Leu Asp Glu Glu Asp Tyr Trp Phe Leu Leu 
                485                 490                 495     


Phe Thr Thr Gln Asn Arg Phe Ile Ser Ser Arg Gln His Lys Arg Glu 
            500                 505                 510         


Phe Ile Gly Lys Glu Glu Asn Ile Leu Leu Tyr Lys Arg Ile Gln Gln 
        515                 520                 525             


Ser Leu Glu Leu Ser Gln Ala Leu Ala Asp Met Lys Glu Met Asp Tyr 
    530                 535                 540                 


Arg Gln Trp Arg Lys Ile Ala Thr Glu Asp Leu Lys Gln Gly Gly Ser 
545                 550                 555                 560 


Leu Gln Val Glu Leu Thr Ser Pro Val Phe Leu Thr Asp Ile Thr Lys 
                565                 570                 575     


Met Ser Phe Glu Glu Leu Cys Tyr Lys Asn Pro Lys Met Ala Ile Gln 
            580                 585                 590         


Lys Ile Ser Asp Asp Tyr Lys Ile Tyr Cys Glu Lys Ala Pro Lys Ile 
        595                 600                 605             


Asp Phe Lys Met Glu Ile Ile Lys Glu Thr Lys Thr Val Ser Arg Ser 
    610                 615                 620                 


Asn Arg Lys Met Ser Leu Leu Lys Arg Thr Leu Val Arg Lys Pro Ser 
625                 630                 635                 640 


Met Arg Pro Arg Asn Leu Thr Glu Val Leu Leu Asn Thr Gln His Leu 
                645                 650                 655     


Glu Phe Phe Arg Glu Phe Leu Lys Glu Arg Lys Ala Lys Ile Pro Leu 
            660                 665                 670         


Gln Phe Leu Thr Ala Val Gln Lys Ile Ser Ile Glu Thr Asn Glu Lys 
        675                 680                 685             


Ile Cys Lys Ser Leu Ile Glu Asn Val Ile Lys Thr Phe Phe Gln Gly 
    690                 695                 700                 


Gln Leu Ser Pro Glu Glu Met Leu Gln Cys Asp Ala Pro Ile Ile Lys 
705                 710                 715                 720 


Glu Ile Ala Ser Met Arg His Val Thr Thr Ser Thr Leu Leu Thr Leu 
                725                 730                 735     


Gln Gly His Val Met Lys Ser Ile Glu Glu Lys Trp Phe Lys Asp Tyr 
            740                 745                 750         


Gln Asp Leu Phe Pro Pro His His Gln Glu Val Glu Val Gln Ser Glu 
        755                 760                 765             


Val Gln Ile Ser Ser Arg Lys Pro Ser Lys Ile Val Ser Thr Tyr Leu 
    770                 775                 780                 


Gln Glu Ser Gln Lys Lys Gly Trp Met Arg Met Ile Ser Phe Ile Arg 
785                 790                 795                 800 


Ser Phe Cys Lys Tyr Arg Arg Phe Met Leu Asn Pro Ser Lys Arg Gln 
                805                 810                 815     


Glu Phe Glu Asp Tyr Leu His Gln Glu Met Gln Asn Ser Lys Glu Asn 
            820                 825                 830         


Phe Thr Thr Ala His Asn Thr Ser Gly Arg Ser Ala Pro Pro Ser Thr 
        835                 840                 845             


Asn Val Arg Ser Ala Asp Gln Glu Asn Gly Glu Ile Thr Leu Val Lys 
    850                 855                 860                 


Arg Arg Ile Phe Gly His Arg Ile Ile Thr Val Asn Phe Ala Ile Asn 
865                 870                 875                 880 


Asp Leu Tyr Phe Phe Ser Glu Met Glu Lys Phe Asn Asp Leu Val Ser 
                885                 890                 895     


Ser Ala His Met Leu Gln Val Asn Arg Ala Tyr Asn Glu Asn Asp Val 
            900                 905                 910         


Ile Leu Met Arg Ser Lys Met Asn Ile Ile Gln Lys Leu Phe Leu Asn 
        915                 920                 925             


Ser Asp Ile Pro Pro Lys Leu Arg Val Asn Val Pro Glu Phe Gln Lys 
    930                 935                 940                 


Asp Ala Ile Leu Ala Ala Ile Thr Glu Gly Tyr Leu Asp Arg Ser Val 
945                 950                 955                 960 


Phe His Gly Ala Ile Met Ser Val Phe Pro Val Val Met Tyr Phe Trp 
                965                 970                 975     


Lys Arg Phe Cys Phe Trp Lys Ala Thr Arg Ser Tyr Leu Gln Tyr Arg 
            980                 985                 990         


Gly Lys Lys Phe Lys Asp Arg Lys  Ser Pro Pro Lys Ser  Thr Asp Lys 
        995                 1000                 1005             


Tyr Pro  Phe Ser Ser Gly Gly  Asp Asn Ala Ile Leu  Arg Phe Thr 
    1010                 1015                 1020             


Leu Leu  Arg Gly Ile Glu Trp  Leu Gln Pro Gln Arg  Glu Ala Ile 
    1025                 1030                 1035             


Ser Ser  Val Gln Asn Ser Ser  Ser Ser Lys Leu Thr  Gln Pro Arg 
    1040                 1045                 1050             


Leu Val  Val Ser Ala Met Gln  Leu His Pro Val Gln  Gly Gln Lys 
    1055                 1060                 1065             


Leu Ser  Tyr Ile Lys Lys Glu  Lys 
    1070                 1075     


<210>  1616
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  1616

Met Ser Leu Gln Trp Thr Ala Val Ala Thr Phe Leu Tyr Ala Glu Val 
1               5                   10                  15      


Phe Val Val Leu Leu Leu Cys Ile Pro Phe Ile Ser Pro Lys Arg Trp 
            20                  25                  30          


Gln Lys Ile Phe Lys Ser Arg Leu Val Glu Leu Leu Val Ser Tyr Gly 
        35                  40                  45              


Asn Thr Phe Phe Val Val Leu Ile Val Ile Leu Val Leu Leu Val Ile 
    50                  55                  60                  


Asp Ala Val Arg Glu Ile Arg Lys Tyr Asp Asp Val Thr Glu Lys Val 
65                  70                  75                  80  


Asn Leu Gln Asn Asn Pro Gly Ala Met Glu His Phe His Met Lys Leu 
                85                  90                  95      


Phe Arg Ala Gln Arg Asn Leu Tyr Ile Ala Gly Phe Ser Leu Leu Leu 
            100                 105                 110         


Ser Phe Leu Leu Arg Arg Leu Val Thr Leu Ile Ser Gln Gln Ala Thr 
        115                 120                 125             


Leu Leu Ala Ser Asn Glu Ala Phe Lys Lys Gln Ala Glu Ser Ala Ser 
    130                 135                 140                 


Glu Ala Ala Lys Lys Tyr Met Glu Glu Asn Asp Gln Leu Lys Lys Gly 
145                 150                 155                 160 


Ala Ala Val Asp Gly Gly Lys Leu Asp Val Gly Asn Ala Glu Val Lys 
                165                 170                 175     


Leu Glu Glu Glu Asn Arg Ser Leu Lys Ala Asp Leu Gln Lys Leu Lys 
            180                 185                 190         


Asp Glu Leu Ala Ser Thr Lys Gln Lys Leu Glu Lys Ala Glu Asn Gln 
        195                 200                 205             


Val Leu Ala Met Arg Lys Gln Ser Glu Gly Leu Thr Lys Glu Tyr Asp 
    210                 215                 220                 


Arg Leu Leu Glu Glu His Ala Lys Leu Gln Ala Ala Val Asp Gly Pro 
225                 230                 235                 240 


Met Asp Lys Lys Glu Glu 
                245     


<210>  1617
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  1617

Met Phe Glu Lys Leu Thr Leu Tyr Cys Asp Ser Tyr Ile Gln Leu Ile 
1               5                   10                  15      


Pro Ile Ser Phe Val Leu Gly Phe Tyr Val Thr Leu Val Val Thr Arg 
            20                  25                  30          


Trp Trp Asn Gln Tyr Glu Asn Leu Pro Trp Pro Asp Arg Leu Met Ser 
        35                  40                  45              


Leu Val Ser Gly Phe Val Glu Gly Lys Asp Glu Gln Gly Arg Leu Leu 
    50                  55                  60                  


Arg Arg Thr Leu Ile Arg Tyr Ala Asn Leu Gly Asn Val Leu Ile Leu 
65                  70                  75                  80  


Arg Ser Val Ser Thr Ala Val Tyr Lys Arg Phe Pro Ser Ala Gln His 
                85                  90                  95      


Leu Val Gln Ala Gly Phe Met Thr Pro Ala Glu His Lys Gln Leu Glu 
            100                 105                 110         


Lys Leu Ser Leu Pro His Asn Met Phe Trp Val Pro Trp Val Trp Phe 
        115                 120                 125             


Ala Asn Leu Ser Met Lys Ala Trp Leu Gly Gly Arg Ile Arg Asp Pro 
    130                 135                 140                 


Ile Leu Leu Gln Ser Leu Leu Asn Glu Met Asn Thr Leu Arg Thr Gln 
145                 150                 155                 160 


Cys Gly His Leu Tyr Ala Tyr Asp Trp Ile Ser Ile Pro Leu Val Tyr 
                165                 170                 175     


Thr Gln Val Val Thr Val Ala Val Tyr Ser Phe Phe Leu Thr Cys Leu 
            180                 185                 190         


Val Gly Arg Gln Phe Leu Asn Pro Ala Lys Ala Tyr Pro Gly His Glu 
        195                 200                 205             


Leu Asp Leu Val Val Pro Val Phe Thr Phe Leu Gln Phe Phe Phe Tyr 
    210                 215                 220                 


Val Gly Trp Leu Lys Val Ala Glu Gln Leu Ile Asn Pro Phe Gly Glu 
225                 230                 235                 240 


Asp Asp Asp Asp Phe Glu Thr Asn Trp Ile Val Asp Arg Asn Leu Gln 
                245                 250                 255     


Val Ser Leu Leu Ala Val Asp Glu Met His Gln Asp Leu Pro Arg Met 
            260                 265                 270         


Glu Pro Asp Met Tyr Trp Asn Lys Pro Glu Pro Gln Pro Pro Tyr Thr 
        275                 280                 285             


Ala Ala Ser Ala Gln Phe Arg Arg Ala Ser Phe Met Gly Ser Thr Phe 
    290                 295                 300                 


Asn Ile Ser Leu Asn Lys Glu Glu Met Glu Phe Gln Pro Asn Gln Glu 
305                 310                 315                 320 


Asp Glu Glu Asp Ala His Ala Gly Ile Ile Gly Arg Phe Leu Gly Leu 
                325                 330                 335     


Gln Ser His Asp His His Pro Pro Arg Ala Asn Ser Arg Thr Lys Leu 
            340                 345                 350         


Leu Trp Pro Lys Arg Glu Ser Leu Leu His Glu Gly Leu Pro Lys Asn 
        355                 360                 365             


His Lys Ala Ala Lys Gln Asn Val Arg Gly Gln Glu Asp Asn Lys Ala 
    370                 375                 380                 


Trp Lys Leu Lys Ala Val Asp Ala Phe Lys Ser Ala Pro Leu Tyr Gln 
385                 390                 395                 400 


Arg Pro Gly Tyr Tyr Ser Ala Pro Gln Thr Pro Leu Ser Pro Thr Pro 
                405                 410                 415     


Met Phe Phe Pro Leu Glu Pro Ser Ala Pro Ser Lys Leu His Ser Val 
            420                 425                 430         


Thr Gly Ile Asp Thr Lys Asp Lys Ser Leu Lys Thr Val Ser Ser Gly 
        435                 440                 445             


Ala Lys Lys Ser Phe Glu Leu Leu Ser Glu Ser Asp Gly Ala Leu Met 
    450                 455                 460                 


Glu His Pro Glu Val Ser Gln Val Arg Arg Lys Thr Val Glu Phe Asn 
465                 470                 475                 480 


Leu Thr Asp Met Pro Glu Ile Pro Glu Asn His Leu Lys Glu Pro Leu 
                485                 490                 495     


Glu Gln Ser Pro Thr Asn Ile His Thr Thr Leu Lys Asp His Met Asp 
            500                 505                 510         


Pro Tyr Trp Ala Leu Glu Asn Arg Ser Val Leu His Leu Asn Gln Gly 
        515                 520                 525             


His Cys Ile Ala Leu Cys Pro Thr Pro Ala Ser Leu Ala Leu Ser Leu 
    530                 535                 540                 


Pro Phe Leu His Asn Phe Leu Gly Phe His His Cys Gln Ser Thr Leu 
545                 550                 555                 560 


Asp Leu Arg Pro Ala Leu Ala Trp Gly Ile Tyr Leu Ala Thr Phe Thr 
                565                 570                 575     


Gly Ile Leu Gly Lys Cys Ser Gly Pro Phe Leu Thr Ser Pro Trp Tyr 
            580                 585                 590         


His Pro Glu Asp Phe Leu Gly Pro Gly Glu Gly Arg 
        595                 600                 


<210>  1618
<211>  492
<212>  PRT
<213>  Homo sapiens

<400>  1618

Met Ala Thr Lys Pro Thr Glu Pro Val Thr Ile Leu Ser Leu Arg Lys 
1               5                   10                  15      


Leu Ser Leu Gly Thr Ala Glu Pro Gln Val Lys Glu Pro Lys Thr Phe 
            20                  25                  30          


Thr Val Glu Asp Ala Val Glu Thr Ile Gly Phe Gly Arg Phe His Ile 
        35                  40                  45              


Ala Leu Phe Leu Ile Met Gly Ser Thr Gly Val Val Glu Ala Met Glu 
    50                  55                  60                  


Ile Met Leu Ile Ala Val Val Ser Pro Val Ile Arg Cys Glu Trp Gln 
65                  70                  75                  80  


Leu Glu Asn Trp Gln Val Ala Leu Val Thr Thr Met Val Phe Phe Gly 
                85                  90                  95      


Tyr Met Val Phe Ser Ile Leu Phe Gly Leu Leu Ala Asp Arg Tyr Gly 
            100                 105                 110         


Arg Trp Lys Ile Leu Leu Ile Ser Phe Leu Trp Gly Ala Tyr Phe Ser 
        115                 120                 125             


Leu Leu Thr Ser Phe Ala Pro Ser Tyr Ile Trp Phe Val Phe Leu Arg 
    130                 135                 140                 


Thr Met Val Gly Cys Gly Val Ser Gly His Ser Gln Gly Leu Ile Ile 
145                 150                 155                 160 


Lys Thr Glu Phe Leu Pro Thr Lys Tyr Arg Gly Tyr Met Leu Pro Leu 
                165                 170                 175     


Ser Gln Val Phe Trp Leu Ala Gly Ser Leu Leu Ile Ile Gly Leu Ala 
            180                 185                 190         


Ser Val Ile Ile Pro Thr Ile Gly Trp Arg Trp Leu Ile Arg Val Ala 
        195                 200                 205             


Ser Ile Pro Gly Ile Ile Leu Ile Val Ala Phe Lys Phe Ile Pro Glu 
    210                 215                 220                 


Ser Ala Arg Phe Asn Val Ser Thr Gly Asn Thr Arg Ala Ala Leu Ala 
225                 230                 235                 240 


Thr Leu Glu Arg Val Ala Lys Met Asn Arg Ser Val Met Pro Glu Gly 
                245                 250                 255     


Lys Leu Val Glu Pro Val Leu Glu Lys Arg Gly Arg Phe Ala Asp Leu 
            260                 265                 270         


Leu Asp Ala Lys Tyr Leu Arg Thr Thr Leu Gln Ile Trp Val Ile Trp 
        275                 280                 285             


Leu Gly Ile Ser Phe Ala Tyr Tyr Gly Val Ile Leu Ala Ser Ala Glu 
    290                 295                 300                 


Leu Leu Glu Arg Asp Leu Val Cys Gly Ser Lys Ser Asp Ser Ala Val 
305                 310                 315                 320 


Val Val Thr Gly Gly Asp Ser Gly Glu Ser Gln Ser Pro Cys Tyr Cys 
                325                 330                 335     


His Met Phe Ala Pro Ser Asp Tyr Arg Thr Met Ile Ile Ser Thr Ile 
            340                 345                 350         


Gly Glu Ile Ala Leu Asn Pro Leu Asn Ile Leu Gly Ile Asn Phe Leu 
        355                 360                 365             


Gly Arg Arg Leu Ser Leu Ser Ile Thr Met Gly Cys Thr Ala Leu Phe 
    370                 375                 380                 


Phe Leu Leu Leu Asn Ile Cys Thr Ser Ser Ala Gly Leu Ile Gly Phe 
385                 390                 395                 400 


Leu Phe Met Leu Arg Ala Leu Val Ala Ala Asn Phe Asn Thr Val Tyr 
                405                 410                 415     


Ile Tyr Thr Ala Glu Val Tyr Pro Thr Thr Met Arg Ala Leu Gly Met 
            420                 425                 430         


Gly Thr Ser Gly Ser Leu Cys Arg Ile Gly Ala Met Val Ala Pro Phe 
        435                 440                 445             


Ile Ser Gln Val Leu Met Ser Ala Ser Ile Leu Gly Ala Leu Cys Leu 
    450                 455                 460                 


Phe Ser Ser Val Cys Val Val Cys Ala Ile Ser Ala Phe Thr Leu Pro 
465                 470                 475                 480 


Ile Glu Thr Lys Gly Arg Ala Leu Gln Gln Ile Lys 
                485                 490         


<210>  1619
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  1619

Met Gly Ala Glu Ala Ser Ser Ser Trp Cys Pro Gly Thr Ala Leu Pro 
1               5                   10                  15      


Glu Glu Arg Leu Ser Val Lys Arg Ala Ser Glu Ile Ser Gly Phe Leu 
            20                  25                  30          


Gly Gln Gly Ser Ser Gly Glu Ala Ala Leu Asp Val Leu Thr His Val 
        35                  40                  45              


Leu Glu Gly Ala Gly Asn Lys Leu Thr Ser Ser Cys Gly Lys Pro Ser 
    50                  55                  60                  


Ser Asn Arg Met Ser Leu Gln Trp Thr Ala Val Ala Thr Phe Leu Tyr 
65                  70                  75                  80  


Ala Glu Val Phe Val Val Leu Leu Leu Cys Ile Pro Phe Ile Ser Pro 
                85                  90                  95      


Lys Arg Trp Gln Lys Ile Phe Lys Ser Arg Leu Val Glu Leu Leu Val 
            100                 105                 110         


Ser Tyr Gly Asn Thr Phe Phe Val Val Leu Ile Val Ile Leu Val Leu 
        115                 120                 125             


Leu Val Ile Asp Ala Val Arg Glu Ile Arg Lys Tyr Asp Asp Val Thr 
    130                 135                 140                 


Glu Lys Val Asn Leu Gln Asn Asn Pro Gly Ala Met Glu His Phe His 
145                 150                 155                 160 


Met Lys Leu Phe Arg Ala Gln Arg Asn Leu Tyr Ile Ala Gly Phe Ser 
                165                 170                 175     


Leu Leu Leu Ser Phe Leu Leu Arg Arg Leu Val Thr Leu Ile Ser Gln 
            180                 185                 190         


Gln Ala Thr Leu Leu Ala Ser Asn Glu Ala Phe Lys Lys Gln Ala Glu 
        195                 200                 205             


Ser Ala Ser Glu Ala Ala Lys Lys Tyr Met Glu Glu Asn Asp Gln Leu 
    210                 215                 220                 


Lys Lys Gly Ala Ala Val Asp Gly Gly Lys Leu Asp Val Gly Asn Ala 
225                 230                 235                 240 


Glu Val Lys Leu Glu Glu Glu Asn Arg Ser Leu Lys Ala Asp Leu Gln 
                245                 250                 255     


Lys Leu Lys Asp Glu Leu Ala Ser Thr Lys Gln Lys Leu Glu Lys Ala 
            260                 265                 270         


Glu Asn Gln Val Leu Ala Met Arg Lys Gln Ser Glu Gly Leu Thr Lys 
        275                 280                 285             


Glu Tyr Asp Arg Leu Leu Glu Glu His Ala Lys Leu Gln Ala Ala Val 
    290                 295                 300                 


Asp Gly Pro Met Asp Lys Lys Glu Glu 
305                 310             


<210>  1620
<211>  616
<212>  PRT
<213>  Homo sapiens

<400>  1620

Met Asp Asp Ser Asp Thr Pro Thr Tyr Tyr Leu Gln Ile Glu Pro Gln 
1               5                   10                  15      


Asp Gly Cys His Pro Gly Asp Ser Val Glu Arg Ser Val Thr Cys Leu 
            20                  25                  30          


Pro Ser Ala Ser Asp Glu Asn Glu Asn Gln Leu Asp Gly Asp Gly His 
        35                  40                  45              


Glu His Leu Thr Ser Ser Asp Ser Ala Met Gly Lys Pro Gln Val Ser 
    50                  55                  60                  


Glu Gln Asp Ser Leu Asn Asn Asn Glu Ser Cys Thr Leu Ser Cys Glu 
65                  70                  75                  80  


Val Ala Ala Gly Glu Asn Leu Gln Asn Thr Leu Cys Glu Ala Ser Arg 
                85                  90                  95      


Asp Glu Gln Ala Phe Leu Gly Lys Asp Lys Lys Ile Pro Gly Lys Arg 
            100                 105                 110         


Ser Pro Arg Ser Lys Lys Gly Thr Ala Lys Lys Ile Pro Pro Gly Leu 
        115                 120                 125             


Phe Ser Gly Asp Ile Ala Pro Leu Met Gln Glu Lys Val Leu Ser Ala 
    130                 135                 140                 


Val Thr Tyr Ala Val Asp Asp Glu Glu Ala Ala Glu Val Asn Ala Asn 
145                 150                 155                 160 


Glu Gln Pro Glu Ala Pro Lys Leu Val Leu Gln Ser Leu Phe Ser Leu 
                165                 170                 175     


Ile Arg Gly Glu Val Glu Gln Leu Asp Ser Arg Ala Leu Pro Leu Cys 
            180                 185                 190         


Leu His Gln Ile Ala Glu Ser Tyr Phe Gln Glu Glu Asp Tyr Glu Lys 
        195                 200                 205             


Ala Met Lys Phe Ile Gln Leu Glu Arg Leu Tyr His Glu Gln Leu Leu 
    210                 215                 220                 


Ala Asn Leu Ser Ala Ile Gln Glu Gln Trp Glu Thr Lys Trp Lys Thr 
225                 230                 235                 240 


Val Gln Pro His Thr Val Thr Ala Leu Arg Asn Ser Glu Lys Gly Phe 
                245                 250                 255     


Asn Gly Glu Asp Phe Glu Arg Leu Thr Lys Ile Cys Ala Thr His Gln 
            260                 265                 270         


Asp Pro Leu Leu Ser Lys His Lys Ile Ala Ala Val Glu Lys Ser Gln 
        275                 280                 285             


Glu Arg Lys Cys Ser Thr Gln Leu Leu Val Ser Glu Asp Pro Lys Glu 
    290                 295                 300                 


Gly Gly Ala Thr Thr Lys Glu Ser Glu Ser Lys Thr Cys Leu Gly Thr 
305                 310                 315                 320 


Glu Ser Ser Lys Glu Ser Gln His Thr Val Glu Pro Leu Gly Ser Ser 
                325                 330                 335     


Pro Cys Cys His Gln Met Asp Val Gln Thr Asp Ser Pro Ser Leu Ser 
            340                 345                 350         


Val Thr Ala Gly Lys Asp His Met Glu Glu Leu Leu Cys Ser Ala Glu 
        355                 360                 365             


Ala Thr Leu Ala Leu His Thr Gln Ser Ser Glu Thr Ala Gly Ser Pro 
    370                 375                 380                 


Ser Gly Pro Asp Ser Ser Glu Asp Ala Cys Glu Asp Asp Ser Arg Leu 
385                 390                 395                 400 


Gln Leu Ala Gln Thr Glu Ala Cys Gln Asp Val Ala Arg Ile Glu Gly 
                405                 410                 415     


Ile Ala Glu Asp Pro Lys Val Phe Leu Ser Ser Lys Ser Lys Thr Glu 
            420                 425                 430         


Pro Leu Ile Ser Pro Gly Cys Asp Arg Ile Pro Pro Ala Leu Ile Ser 
        435                 440                 445             


Glu Gly Lys Tyr Ser Gln Ala Gln Arg Lys Glu Leu Arg Leu Pro Leu 
    450                 455                 460                 


Arg Asp Ala Ser Glu Ala Leu Pro Thr Asp Gln Leu Glu Asn Asn Glu 
465                 470                 475                 480 


Leu Asn Glu Leu Gln Gln Pro Asp Leu Thr Asp Ser Asp Gly Lys Ser 
                485                 490                 495     


Pro Gln Ala Gln Ala Asp Ser Asp Gly Ser Glu Asn Val Leu Cys Gly 
            500                 505                 510         


Asn Asn Gln Ile Ser Asp Leu Gly Ile Leu Leu Pro Glu Val Cys Met 
        515                 520                 525             


Ala Pro Glu Glu Lys Gly Asp Lys Asp Asp Gln Leu Asn Lys Glu Thr 
    530                 535                 540                 


Glu Asp Tyr Leu Asn Ser Leu Leu Glu Gly Cys Leu Lys Asp Thr Glu 
545                 550                 555                 560 


Asp Ser Leu Ser Tyr Glu Asp Asn Gln Asp Asp Asp Ser Asp Leu Leu 
                565                 570                 575     


Gln Asp Leu Ser Pro Glu Glu Ala Ser Tyr Ser Leu Gln Glu Asn Leu 
            580                 585                 590         


Pro Ser Asp Glu Ser Cys Leu Ser Leu Asp Asp Leu Ala Lys Arg Ile 
        595                 600                 605             


Glu Ile Ala Glu Val Asn Gln Arg 
    610                 615     


<210>  1621
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  1621

Met Ala Leu Lys Gln Glu Met Ala Lys Ser Leu Leu Lys Thr Ala Ser 
1               5                   10                  15      


Leu Ser Gly Arg Thr Lys Leu Leu His Gln Thr Gly Leu Ser Leu Tyr 
            20                  25                  30          


Ser Thr Ser His Gly Phe Tyr Glu Glu Glu Val Lys Lys Thr Leu Gln 
        35                  40                  45              


Gln Phe Pro Gly Gly Ser Ile Asp Leu Gln Lys Glu Asp Asn Gly Ile 
    50                  55                  60                  


Gly Ile Leu Thr Leu Asn Asn Pro Ser Arg Met Asn Ala Phe Ser Gly 
65                  70                  75                  80  


Val Met Met Leu Gln Leu Leu Glu Lys Val Ile Glu Leu Glu Asn Trp 
                85                  90                  95      


Thr Glu Gly Lys Gly Leu Ile Val Arg Gly Ala Lys Asn Thr Phe Ser 
            100                 105                 110         


Ser Gly Ser Asp Leu Asn Ala Val Lys Ser Leu Gly Thr Pro Glu Asp 
        115                 120                 125             


Gly Met Ala Val Cys Met Phe Met Gln Asn Thr Leu Thr Arg Phe Met 
    130                 135                 140                 


Arg Leu Pro Leu Ile Ser Val Ala Leu Val Gln Gly Trp Ala Leu Gly 
145                 150                 155                 160 


Gly Gly Ala Glu Phe Thr Thr Ala Cys Asp Phe Arg Leu Met Thr Pro 
                165                 170                 175     


Glu Ser Lys Ile Arg Phe Val His Lys Glu Met Gly Ile Ile Pro Ser 
            180                 185                 190         


Trp Gly Gly Thr Thr Arg Leu Val Glu Ile Ile Gly Ser Arg Gln Ala 
        195                 200                 205             


Leu Lys Val Leu Ser Gly Ala Leu Lys Leu Asp Ser Lys Asn Ala Leu 
    210                 215                 220                 


Asn Ile Gly Met Val Glu Glu Val Leu Gln Ser Ser Asp Glu Thr Lys 
225                 230                 235                 240 


Ser Leu Glu Glu Ala Gln Glu Trp Leu Lys Gln Phe Ile Gln Gly Pro 
                245                 250                 255     


Pro Glu Val Ile Arg Ala Leu Lys Lys Ser Val Cys Ser Gly Arg Glu 
            260                 265                 270         


Leu Tyr Leu Glu Glu Ala Leu Gln Asn Glu Arg Asp Leu Leu Gly Thr 
        275                 280                 285             


Val Trp Gly Gly Pro Ala Asn Leu Glu Ala Ile Ala Lys Lys Gly Lys 
    290                 295                 300                 


Phe Asn Lys 
305         


<210>  1622
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  1622

Met Gly Thr Trp Ile Leu Phe Ala Cys Leu Leu Gly Ala Ala Phe Ala 
1               5                   10                  15      


Met Pro Leu Pro Pro His Pro Gly His Pro Gly Tyr Ile Asn Phe Ser 
            20                  25                  30          


Tyr Glu Val Leu Thr Pro Leu Lys Trp Tyr Gln Ser Ile Arg Pro Pro 
        35                  40                  45              


Tyr Pro Ser Tyr Gly Tyr Glu Pro Met Gly Gly Trp Leu His His Gln 
    50                  55                  60                  


Ile Ile Pro Val Leu Ser Gln Gln His Pro Pro Thr His Thr Leu Gln 
65                  70                  75                  80  


Pro His His His Ile Pro Val Val Pro Ala Gln Gln Pro Val Ile Pro 
                85                  90                  95      


Gln Gln Pro Met Met Pro Val Pro Gly Gln His Ser Met Thr Pro Ile 
            100                 105                 110         


Gln His His Gln Pro Asn Leu Pro Pro Pro Ala Gln Gln Pro Tyr Gln 
        115                 120                 125             


Pro Gln Pro Val Gln Pro Gln Pro His Gln Pro Met Gln Pro Gln Pro 
    130                 135                 140                 


Pro Val His Pro Met Gln Pro Leu Pro Pro Gln Pro Pro Leu Pro Pro 
145                 150                 155                 160 


Met Phe Pro Met Gln Pro Leu Pro Pro Met Leu Pro Asp Leu Thr Leu 
                165                 170                 175     


Glu Ala Trp Pro Ser Thr Asp Lys Thr Lys Arg Glu Glu Val Asp 
            180                 185                 190     


<210>  1623
<211>  643
<212>  PRT
<213>  Homo sapiens

<400>  1623

Met Pro Leu Leu Phe Leu Glu Arg Phe Pro Trp Pro Ser Leu Arg Thr 
1               5                   10                  15      


Tyr Thr Gly Leu Ser Gly Leu Ala Leu Leu Gly Thr Ile Ile Ser Ala 
            20                  25                  30          


Tyr Arg Ala Leu Ser Gln Pro Glu Ala Gly Pro Gly Glu Pro Asp Gln 
        35                  40                  45              


Leu Thr Ala Ser Leu Gln Pro Glu Pro Pro Ala Pro Ala Arg Pro Ser 
    50                  55                  60                  


Ala Gly Gly Pro Arg Ala Arg Asp Val Ala Gln Tyr Leu Leu Ser Asp 
65                  70                  75                  80  


Ser Leu Phe Val Trp Val Leu Val Asn Thr Ala Cys Cys Val Leu Met 
                85                  90                  95      


Leu Val Ala Lys Leu Ile Gln Cys Ile Val Phe Gly Pro Leu Arg Val 
            100                 105                 110         


Ser Glu Arg Gln His Leu Lys Asp Lys Phe Trp Asn Phe Ile Phe Tyr 
        115                 120                 125             


Lys Phe Ile Phe Ile Phe Gly Val Leu Asn Val Gln Thr Val Glu Glu 
    130                 135                 140                 


Val Val Met Trp Cys Leu Trp Phe Ala Gly Leu Val Phe Leu His Leu 
145                 150                 155                 160 


Met Val Gln Leu Cys Lys Asp Arg Phe Glu Tyr Leu Ser Phe Ser Pro 
                165                 170                 175     


Thr Thr Pro Met Ser Ser His Gly Arg Val Leu Ser Leu Leu Val Ala 
            180                 185                 190         


Met Leu Leu Ser Cys Cys Gly Leu Ala Ala Val Cys Ser Ile Thr Gly 
        195                 200                 205             


Tyr Thr His Gly Met His Thr Leu Ala Phe Met Ala Ala Glu Ser Leu 
    210                 215                 220                 


Leu Val Thr Val Arg Thr Ala His Val Ile Leu Arg Tyr Val Ile His 
225                 230                 235                 240 


Leu Trp Asp Leu Asn His Glu Gly Thr Trp Glu Gly Lys Gly Thr Tyr 
                245                 250                 255     


Val Tyr Tyr Thr Asp Phe Val Met Glu Leu Thr Leu Leu Ser Leu Asp 
            260                 265                 270         


Leu Met His His Ile His Met Leu Leu Phe Gly Asn Ile Trp Leu Ser 
        275                 280                 285             


Met Ala Ser Leu Val Ile Phe Met Gln Leu Arg Tyr Leu Phe His Glu 
    290                 295                 300                 


Val Gln Arg Arg Ile Arg Arg His Lys Asn Tyr Leu Arg Val Val Gly 
305                 310                 315                 320 


Asn Met Glu Ala Arg Phe Ala Val Ala Thr Pro Glu Glu Leu Ala Val 
                325                 330                 335     


Asn Asn Asp Asp Cys Ala Ile Cys Trp Asp Ser Met Gln Ala Ala Arg 
            340                 345                 350         


Lys Leu Pro Cys Gly His Leu Phe His Asn Ser Cys Leu Arg Ser Trp 
        355                 360                 365             


Leu Glu Gln Asp Thr Ser Cys Pro Thr Cys Arg Met Ser Leu Asn Ile 
    370                 375                 380                 


Ala Asp Asn Asn Arg Val Arg Glu Glu His Gln Gly Glu Asn Leu Asp 
385                 390                 395                 400 


Glu Asn Leu Val Pro Val Ala Ala Ala Glu Gly Arg Pro Arg Leu Asn 
                405                 410                 415     


Gln His Asn His Phe Phe His Phe Asp Gly Ser Arg Ile Ala Ser Trp 
            420                 425                 430         


Leu Pro Ser Phe Ser Val Glu Val Met His Thr Thr Asn Ile Leu Gly 
        435                 440                 445             


Ile Thr Gln Ala Ser Asn Ser Gln Leu Asn Ala Met Ala His Gln Ile 
    450                 455                 460                 


Gln Glu Met Phe Pro Gln Val Pro Tyr His Leu Val Leu Gln Asp Leu 
465                 470                 475                 480 


Gln Leu Thr Arg Ser Val Glu Ile Thr Thr Asp Asn Ile Leu Glu Gly 
                485                 490                 495     


Arg Ile Gln Val Pro Phe Pro Thr Gln Arg Ser Asp Ser Ile Arg Pro 
            500                 505                 510         


Ala Leu Asn Ser Pro Val Glu Arg Pro Ser Ser Asp Gln Glu Glu Gly 
        515                 520                 525             


Glu Thr Ser Ala Gln Thr Glu Arg Val Pro Leu Asp Leu Ser Pro Arg 
    530                 535                 540                 


Leu Glu Glu Thr Leu Asp Phe Gly Glu Val Glu Val Glu Pro Ser Glu 
545                 550                 555                 560 


Val Glu Asp Phe Glu Ala Arg Gly Ser Arg Phe Ser Lys Ser Ala Asp 
                565                 570                 575     


Glu Arg Gln Arg Met Leu Val Gln Arg Lys Asp Glu Leu Leu Gln Gln 
            580                 585                 590         


Ala Arg Lys Arg Phe Leu Asn Lys Ser Ser Glu Asp Asp Ala Ala Ser 
        595                 600                 605             


Glu Ser Phe Leu Pro Ser Glu Gly Ala Ser Ser Asp Pro Val Thr Leu 
    610                 615                 620                 


Arg Arg Arg Met Leu Ala Ala Ala Ala Glu Arg Arg Leu Gln Lys Gln 
625                 630                 635                 640 


Gln Thr Ser 
            


<210>  1624
<211>  1335
<212>  PRT
<213>  Homo sapiens

<400>  1624

Met Leu Ser Pro Thr Phe Val Leu Trp Glu Val Gly Tyr Pro Leu Tyr 
1               5                   10                  15      


Ile Tyr Gly Ser Ile Phe Ile Val Ile Val Ile Ile Trp Gln Val Lys 
            20                  25                  30          


Arg Ser His His Glu Leu Ser Ser Glu Pro Lys Arg Ser Cys Cys Arg 
        35                  40                  45              


Cys His Gln Lys Val Arg Gln Arg Ala Arg Asp Ala Ala Ser Thr Ala 
    50                  55                  60                  


Arg Arg Arg Ser Arg Glu Glu Ala Glu Lys Pro Gln Lys Leu Leu Ser 
65                  70                  75                  80  


Ile Ile Lys Ser Gln Gly Trp Leu Pro Leu Glu Arg Ser Val Arg Arg 
                85                  90                  95      


Ile Leu Cys Ala Asp Pro Cys Cys Gln Ile Cys Asn Ser Val Ala Leu 
            100                 105                 110         


Glu Ile Gln Gln Leu Leu Val Gly Glu Asn Asn Gln Ile Ser Leu Thr 
        115                 120                 125             


Leu Ser Gly Pro Leu Gln Gly Ser Ser Cys Leu Glu Met Leu Ser Thr 
    130                 135                 140                 


Ser Ser Met Ser Leu Asp Gln Ser Leu Glu Phe His Ser Trp His Thr 
145                 150                 155                 160 


Arg Glu Leu Ser Leu Ser Ser Val Thr Pro Thr Leu Ser Gln Leu Thr 
                165                 170                 175     


Asp Gln Lys Ser Leu Thr Gln Ser Ala Ala Gln Ser Thr Tyr Ala Asp 
            180                 185                 190         


Gly Ile Gln Asp Tyr Trp Ala Asp His Leu Gln Leu Gly Gln Glu Phe 
        195                 200                 205             


Gln Val Pro Asp Val Leu Arg Gly Pro Asn Thr Ile Ala Ser Ser Arg 
    210                 215                 220                 


Ile Glu Lys Pro Arg Ala Pro Leu Asn Gln Glu Glu Met Thr Gln Ser 
225                 230                 235                 240 


Asn Pro Ser Leu Val Gln Gly Asn Gln Gly Gln His His Leu Asn Ser 
                245                 250                 255     


Gln Val Ser Leu Leu Ser Leu Asn Pro Glu Thr Leu Asn Arg Met His 
            260                 265                 270         


Pro Met Ala Leu His Met Val Leu Pro Ala His Leu Pro Phe Leu Ser 
        275                 280                 285             


Pro Glu Val Leu Arg Leu Leu Glu Val His Val Lys Lys Trp Met His 
    290                 295                 300                 


Phe Gln Arg Trp Gly Leu Pro Arg Arg Val Glu Glu Ser Leu Arg Gln 
305                 310                 315                 320 


Leu Met Pro Asn Pro Pro Leu Tyr Tyr Gln Pro Gly Asn Asp Gln Pro 
                325                 330                 335     


Val Ser Phe Asn Leu Lys Asn Thr Pro Gln Val Ser Leu His Arg Phe 
            340                 345                 350         


Glu Thr Ile Ser Leu Gln Thr Trp Cys Ser Cys Val Ala Gly Gln Pro 
        355                 360                 365             


Ile Gln Thr Phe Trp Val Ser Glu Trp Ser Thr Met Asn Pro Glu Gln 
    370                 375                 380                 


Arg His His Cys Gln Gln Thr Pro Asn Pro Met Ala Leu Ala Leu Pro 
385                 390                 395                 400 


Ser Pro Ala Leu Lys Ala Leu Ser Gly Pro His Pro Gln Ser Gly Gly 
                405                 410                 415     


Gln Asp Asn Asp Ser Gly Ser Asp Leu Gln Gln Lys Tyr Ser Gln Leu 
            420                 425                 430         


Phe Cys Gly Leu Pro Ser Leu His Ser Glu Ser Leu Val Ala Thr Phe 
        435                 440                 445             


Met Gly Ser Gln Gly Leu Pro Lys Ile Glu Asn Val Pro Lys Pro Pro 
    450                 455                 460                 


Leu Lys Asp Pro Phe Leu Phe Asn Glu Leu Ser Phe Pro Gln Leu Leu 
465                 470                 475                 480 


Pro Lys Thr Ser Pro Gln Ser Ala Pro Pro Ser Ser Pro Leu Ser Pro 
                485                 490                 495     


Asn Trp Met Ser Pro Ser Asp His Gln Arg Ala Gln Ile Asn Val Pro 
            500                 505                 510         


Phe Leu Thr Leu Ala Glu Tyr Glu Ala Leu Glu Trp His Leu Leu Gln 
        515                 520                 525             


Arg Gln Leu Gln Leu Gln Trp Gly Trp Pro Ala Ala Leu Gln Arg Ser 
    530                 535                 540                 


Gln His Thr Gln Cys Leu Met Gln His Glu Pro Cys Gly Lys Ala Gln 
545                 550                 555                 560 


Ser Pro Glu Thr Thr Thr Ala Ser Gln Thr Gly Lys Ser Ile Ser Val 
                565                 570                 575     


Leu Thr Arg Glu Leu Leu Phe Phe Pro Glu His Ala Arg Lys Leu Leu 
            580                 585                 590         


Glu Phe His Ile Gln Lys Gln Leu Ile Arg His Arg Trp Gly Leu Pro 
        595                 600                 605             


Gln Lys Ile Gln Gln Ser Ile Gln Leu Leu Leu Thr Ser Thr Asp Gln 
    610                 615                 620                 


Gln Thr Val Ser Ser Ser Ser Thr Ala Leu Ala Asn Val Ser Ile Pro 
625                 630                 635                 640 


Gln Pro Val Ala Leu Glu Ala Asn Gly Ala Cys Asp Val Leu Ser Pro 
                645                 650                 655     


Ile Ala Ala Pro Val Ser Ile Pro Arg Pro His Leu Leu Thr Gln Val 
            660                 665                 670         


Lys Ala Ile Leu Gln Ser His Ile Asp Ser Lys Cys Gly Gln Ile His 
        675                 680                 685             


Gln Gly Lys Ile Pro Ala Cys Val His Arg Ser Trp Asp Cys Arg Ile 
    690                 695                 700                 


Ser Gly Val Leu Ala Val Ala Pro Phe Pro Cys Ile Pro Glu Ser Gln 
705                 710                 715                 720 


Phe Leu Glu Leu Gln Thr Ala Ser Asp Pro Asp Leu His His Lys Val 
                725                 730                 735     


Met Pro Trp Met Pro Thr Ala Leu Asp Gln Gln Gln Gln Ala Leu Pro 
            740                 745                 750         


Gly Thr Val Thr Glu His Pro Lys Leu Leu Arg Val Leu Ser Val Glu 
        755                 760                 765             


Ala Ile Glu Lys Leu Glu Thr Thr Leu Arg His Lys His Leu Ala Phe 
    770                 775                 780                 


Leu Ser Gly Leu Pro Ala Leu Tyr Tyr Val Ala Leu Pro Arg Ala Leu 
785                 790                 795                 800 


Ala Pro Ala Val Thr Ser Gln Ser Val Ile Thr Glu Met Glu Pro Ser 
                805                 810                 815     


Pro Val Glu Ile Pro Ala Glu Pro Leu Ile Gln Met Val Ser Phe Glu 
            820                 825                 830         


Glu Gln Cys Ile Ser Leu Gly Pro Cys Pro Gln Gly Asn Asn Glu Ser 
        835                 840                 845             


Cys Thr Asp Val Ala Lys Glu Phe Gln Pro Ala Val Pro Val Lys Gly 
    850                 855                 860                 


Thr Met Glu Thr Leu Pro Leu Glu Ser Gln Thr His Pro Thr Ser Pro 
865                 870                 875                 880 


His Ser Leu Gln Thr His Ile Leu Thr Lys Leu Asn Phe His Leu Arg 
                885                 890                 895     


Lys Lys Val Leu Glu Ile Gln Trp Gly Ile Pro Ile Arg Ala Arg Lys 
            900                 905                 910         


Ser Arg Glu Gln Thr Val Ala Ala Pro Glu Asn Ile Ser Thr Gln Lys 
        915                 920                 925             


Ser Leu Glu Ser Leu Asn His Gln Gly Glu Thr Leu Leu Gln Glu Leu 
    930                 935                 940                 


Pro Ile Pro Pro Asp Thr Leu Pro Ala Pro Asn Pro Glu Gly Val His 
945                 950                 955                 960 


Leu Lys Glu Gln Leu Ala Asn Asp Leu Lys Ala Val Gln Gln Asn Gln 
                965                 970                 975     


Lys Gln Ser Asn Ser Lys Ala Val Pro Gln Gly Ser Ala His Ser Val 
            980                 985                 990         


Ser Lys Ile Ser Gln Pro Ser Gly  Asp Met Thr Glu Ala  His Met Pro 
        995                 1000                 1005             


Cys Val  Gln Val Glu Ala Asn  Val Asn Lys Pro Ser  Leu Glu Glu 
    1010                 1015                 1020             


Pro Cys  Gly Pro Glu Pro Gln  Ser Pro Ser Lys Ser  Lys Asp Pro 
    1025                 1030                 1035             


Ala His  Val Pro Met Leu Ala  Gly Asn Arg Glu Asp  Pro Glu Glu 
    1040                 1045                 1050             


Thr Lys  Ala Ala Arg Asp His  Arg Glu Gly Asp Ala  Gly Phe Gly 
    1055                 1060                 1065             


Arg Ser  Ser Thr Arg Glu Glu  Arg Arg Pro Ala Glu  Asp Gln Arg 
    1070                 1075                 1080             


Pro Ala  Gly Met Leu Pro Asn  Lys Thr Pro Arg Gly  Ser Trp Arg 
    1085                 1090                 1095             


Trp Ser  Arg Ser Phe His Leu  Ala Asp Pro Cys Gln  His Ser Pro 
    1100                 1105                 1110             


Gln His  His Pro Gln Leu Lys  Leu Pro Gln Leu Pro  Pro Arg Val 
    1115                 1120                 1125             


Pro Gly  Glu Lys Glu Ser Glu  Lys Asp Leu Gln Asp  Ser Gln Thr 
    1130                 1135                 1140             


Lys Leu  Thr Val Ile Leu Glu  Pro Ala Thr Ile Pro  Glu Asn Ala 
    1145                 1150                 1155             


Gln Thr  Val Leu Pro Gln Ala  Ser Gln Gly Gln Pro  Phe Leu Ser 
    1160                 1165                 1170             


Gln Pro  Thr Gln Ala Lys Pro  Leu Gln Gly Gln Thr  Leu Gln Gly 
    1175                 1180                 1185             


Gln Val  Leu His Gly Leu Val  Met Pro Val His Ala  Gln Lys Lys 
    1190                 1195                 1200             


Pro Ser  Leu Thr Glu Ser Ser  Phe Arg Asn Lys Ile  Lys Cys Phe 
    1205                 1210                 1215             


Leu Gln  His Ile Asn Pro Lys  Thr Lys Gly Lys Gly  His Glu Asp 
    1220                 1225                 1230             


Ser Met  Phe Ser Ala Ala Ala  Lys Val Ala Lys Thr  Arg Lys Glu 
    1235                 1240                 1245             


Asn Val  Ala Lys Ser Leu Ala  Pro Ala Lys Ser Pro  Val Gly Arg 
    1250                 1255                 1260             


Ser Lys  Thr Glu Lys Pro Thr  Gly Cys Ser Lys Ala  Gln Ser Arg 
    1265                 1270                 1275             


Pro Ala  Gln Lys Leu Val Gly  Pro Ala Phe Leu Asp  Gly Pro Gln 
    1280                 1285                 1290             


Ser Leu  Asp Asp Lys Leu Arg  Leu His Ser Arg Gln  Pro Gly Ser 
    1295                 1300                 1305             


Ala Ser  Ala Leu Gly Tyr Pro  Arg His Cys Pro Arg  His Cys Pro 
    1310                 1315                 1320             


Arg Glu  Ala Cys Ala Asn Lys  Pro Gly His Pro Thr  
    1325                 1330                 1335 


<210>  1625
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  1625

Met Glu Ser Trp Trp Gly Leu Pro Cys Leu Ala Phe Leu Cys Phe Leu 
1               5                   10                  15      


Met His Ala Arg Gly Gln Arg Asp Phe Asp Leu Ala Asp Ala Leu Asp 
            20                  25                  30          


Asp Pro Glu Pro Thr Lys Lys Pro Asn Ser Asp Ile Tyr Pro Lys Pro 
        35                  40                  45              


Lys Pro Pro Tyr Tyr Pro Gln Pro Glu Asn Pro Asp Ser Gly Gly Asn 
    50                  55                  60                  


Ile Tyr Pro Arg Pro Lys Pro Arg Pro Gln Pro Gln Pro Gly Asn Ser 
65                  70                  75                  80  


Gly Asn Ser Gly Gly Tyr Phe Asn Asp Val Asp Arg Asp Asp Gly Arg 
                85                  90                  95      


Tyr Pro Pro Arg Pro Arg Pro Arg Pro Pro Ala Gly Gly Gly Gly Gly 
            100                 105                 110         


Gly Tyr Ser Ser Tyr Gly Asn Ser Asp Asn Thr His Gly Arg Gly Gly 
        115                 120                 125             


Tyr Arg Leu Asn Ser Arg Tyr Gly Asn Thr Tyr Gly Gly Asp His His 
    130                 135                 140                 


Ser Thr Tyr Gly Asn Pro Glu Gly Asn Met Val Ala Lys Ile Val Ser 
145                 150                 155                 160 


Pro Ile Val Ser Val Val Val Val Thr Leu Leu Gly Ala Ala Ala Ser 
                165                 170                 175     


Tyr Phe Lys Leu Asn Asn Arg Arg Asn Cys Phe Arg Thr His Glu Pro 
            180                 185                 190         


Glu Asn Val 
        195 


<210>  1626
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  1626

Met Glu Ser Trp Trp Gly Leu Pro Cys Leu Ala Phe Leu Cys Phe Leu 
1               5                   10                  15      


Met His Ala Arg Gly Gln Arg Asp Phe Asp Leu Ala Asp Ala Leu Asp 
            20                  25                  30          


Asp Pro Glu Pro Thr Lys Lys Pro Asn Ser Asp Ile Tyr Pro Lys Pro 
        35                  40                  45              


Lys Pro Pro Tyr Tyr Pro Gln Pro Glu Asn Pro Asp Ser Gly Gly Asn 
    50                  55                  60                  


Ile Tyr Pro Arg Pro Lys Pro Arg Pro Gln Pro Gln Pro Gly Asn Ser 
65                  70                  75                  80  


Gly Asn Ser Gly Gly Ser Tyr Phe Asn Asp Val Asp Arg Asp Asp Gly 
                85                  90                  95      


Arg Tyr Pro Pro Arg Pro Arg Pro Arg Pro Pro Ala Gly Gly Gly Gly 
            100                 105                 110         


Gly Gly Tyr Ser Ser Tyr Gly Asn Ser Asp Asn Thr His Gly Gly Asp 
        115                 120                 125             


His His Ser Thr Tyr Gly Asn Pro Glu Gly Asn Met Val Ala Lys Ile 
    130                 135                 140                 


Val Ser Pro Ile Val Ser Val Val Val Val Thr Leu Leu Gly Ala Ala 
145                 150                 155                 160 


Ala Ser Tyr Phe Lys Leu Asn Asn Arg Arg Asn Cys Phe Arg Thr His 
                165                 170                 175     


Glu Pro Glu Asn Val 
            180     


<210>  1627
<211>  701
<212>  PRT
<213>  Homo sapiens

<400>  1627

Met Ala Val Ser Ala Gly Ser Ala Arg Thr Ser Pro Ser Ser Gly Phe 
1               5                   10                  15      


Leu Met Val Leu Asp Ile Pro Gln Glu Arg Gly Leu Ser Ser Leu Asp 
            20                  25                  30          


Arg Lys Tyr Leu Asp Gly Leu Asp Val Cys Arg Phe Pro Leu Leu Asp 
        35                  40                  45              


Ala Leu Arg Pro Leu Pro Leu Asp Trp Met Tyr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Met Phe Leu Gly Ala Leu Gly Met Met Leu Gly Leu Cys Tyr Arg Ile 
65                  70                  75                  80  


Ser Cys Val Leu Phe Leu Leu Pro Tyr Trp Tyr Val Phe Leu Leu Asp 
                85                  90                  95      


Lys Thr Ser Trp Asn Asn His Ser Tyr Leu Tyr Gly Leu Leu Ala Phe 
            100                 105                 110         


Gln Leu Thr Phe Met Asp Ala Asn His Tyr Trp Ser Val Asp Gly Leu 
        115                 120                 125             


Leu Asn Ala His Arg Arg Asn Ala His Val Pro Leu Trp Asn Tyr Ala 
    130                 135                 140                 


Val Leu Arg Gly Gln Ile Phe Ile Val Tyr Phe Ile Ala Gly Val Lys 
145                 150                 155                 160 


Lys Leu Asp Ala Asp Trp Val Glu Gly Tyr Ser Met Glu Tyr Leu Ser 
                165                 170                 175     


Arg His Trp Leu Phe Ser Pro Phe Lys Leu Leu Leu Ser Glu Glu Leu 
            180                 185                 190         


Thr Ser Leu Leu Val Val His Trp Gly Gly Leu Leu Leu Asp Leu Ser 
        195                 200                 205             


Ala Gly Phe Leu Leu Phe Phe Asp Val Ser Arg Ser Ile Gly Leu Phe 
    210                 215                 220                 


Phe Val Ser Tyr Phe His Cys Met Asn Ser Gln Leu Phe Ser Ile Gly 
225                 230                 235                 240 


Met Phe Ser Tyr Val Met Leu Ala Ser Ser Pro Leu Phe Cys Ser Pro 
                245                 250                 255     


Glu Trp Pro Arg Lys Leu Val Ser Tyr Cys Pro Arg Arg Leu Gln Gln 
            260                 265                 270         


Leu Leu Pro Leu Lys Ala Ala Pro Gln Pro Ser Val Ser Cys Val Tyr 
        275                 280                 285             


Lys Arg Ser Arg Gly Lys Ser Gly Gln Lys Pro Gly Leu Arg His Gln 
    290                 295                 300                 


Leu Gly Ala Ala Phe Thr Leu Leu Tyr Leu Leu Glu Gln Leu Phe Leu 
305                 310                 315                 320 


Pro Tyr Ser His Phe Leu Thr Gln Gly Tyr Asn Asn Trp Thr Asn Gly 
                325                 330                 335     


Leu Tyr Gly Tyr Ser Trp Asp Met Met Val His Ser Arg Ser His Gln 
            340                 345                 350         


His Val Lys Ile Thr Tyr Arg Asp Gly Arg Thr Gly Glu Leu Gly Tyr 
        355                 360                 365             


Leu Asn Pro Gly Val Phe Thr Gln Ser Arg Arg Trp Lys Asp His Ala 
    370                 375                 380                 


Asp Met Leu Lys Gln Tyr Ala Thr Cys Leu Ser Arg Leu Leu Pro Lys 
385                 390                 395                 400 


Tyr Asn Val Thr Glu Pro Gln Ile Tyr Phe Asp Ile Trp Val Ser Ile 
                405                 410                 415     


Asn Asp Arg Phe Gln Gln Arg Ile Phe Asp Pro Arg Val Asp Ile Val 
            420                 425                 430         


Gln Ala Ala Trp Ser Pro Phe Gln Arg Thr Ser Trp Val Gln Pro Leu 
        435                 440                 445             


Leu Met Asp Leu Ser Pro Trp Arg Ala Lys Leu Gln Glu Ile Lys Ser 
    450                 455                 460                 


Ser Leu Asp Asn His Thr Glu Val Val Phe Ile Ala Asp Phe Pro Gly 
465                 470                 475                 480 


Leu His Leu Glu Asn Phe Val Ser Glu Asp Leu Gly Asn Thr Ser Ile 
                485                 490                 495     


Gln Leu Leu Gln Gly Glu Val Thr Val Glu Leu Val Ala Glu Gln Lys 
            500                 505                 510         


Asn Gln Thr Leu Arg Glu Gly Glu Lys Met Gln Leu Pro Ala Gly Glu 
        515                 520                 525             


Tyr His Lys Val Tyr Thr Thr Ser Pro Ser Pro Ser Cys Tyr Met Tyr 
    530                 535                 540                 


Val Tyr Val Asn Thr Thr Glu Leu Ala Leu Glu Gln Asp Leu Ala Tyr 
545                 550                 555                 560 


Leu Gln Glu Leu Lys Glu Lys Val Glu Asn Gly Ser Glu Thr Gly Pro 
                565                 570                 575     


Leu Pro Pro Glu Leu Gln Pro Leu Leu Glu Gly Glu Val Lys Gly Gly 
            580                 585                 590         


Pro Glu Pro Thr Pro Leu Val Gln Thr Phe Leu Arg Arg Gln Gln Arg 
        595                 600                 605             


Leu Gln Glu Ile Glu Arg Arg Arg Asn Thr Pro Phe His Glu Arg Phe 
    610                 615                 620                 


Phe Arg Phe Leu Leu Arg Lys Leu Tyr Val Phe Arg Arg Ser Phe Leu 
625                 630                 635                 640 


Met Thr Cys Ile Ser Leu Arg Asn Leu Ile Leu Gly Arg Pro Ser Leu 
                645                 650                 655     


Glu Gln Leu Ala Gln Glu Val Thr Tyr Ala Asn Leu Arg Pro Phe Glu 
            660                 665                 670         


Ala Val Gly Glu Leu Asn Pro Ser Asn Thr Asp Ser Ser His Ser Asn 
        675                 680                 685             


Pro Pro Glu Ser Asn Pro Asp Pro Val His Ser Glu Phe 
    690                 695                 700     


<210>  1628
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  1628

Met Leu Phe Trp Val Leu Gly Leu Leu Ile Leu Cys Gly Phe Leu Trp 
1               5                   10                  15      


Thr Arg Lys Gly Lys Leu Lys Ile Glu Asp Ile Thr Asp Lys Tyr Ile 
            20                  25                  30          


Phe Ile Thr Gly Cys Asp Ser Gly Phe Gly Asn Leu Ala Ala Arg Thr 
        35                  40                  45              


Phe Asp Lys Lys Gly Phe His Val Ile Ala Ala Cys Leu Thr Glu Ser 
    50                  55                  60                  


Gly Ser Thr Ala Leu Lys Ala Glu Thr Ser Glu Arg Leu Arg Thr Val 
65                  70                  75                  80  


Leu Leu Asp Val Thr Asp Pro Glu Asn Val Lys Arg Thr Ala Gln Trp 
                85                  90                  95      


Val Lys Asn Gln Val Gly Glu Lys Gly Leu Trp Gly Leu Ile Asn Asn 
            100                 105                 110         


Ala Gly Val Pro Gly Val Leu Ala Pro Thr Asp Trp Leu Thr Leu Glu 
        115                 120                 125             


Asp Tyr Arg Glu Pro Ile Glu Val Asn Leu Phe Gly Leu Ile Ser Val 
    130                 135                 140                 


Thr Leu Asn Met Leu Pro Leu Val Lys Lys Ala Gln Gly Arg Val Ile 
145                 150                 155                 160 


Asn Val Ser Ser Val Gly Gly Arg Leu Ala Ile Val Gly Gly Gly Tyr 
                165                 170                 175     


Thr Pro Ser Lys Tyr Ala Val Glu Gly Phe Asn Asp Ser Leu Arg Arg 
            180                 185                 190         


Asp Met Lys Ala Phe Gly Val His Val Ser Cys Ile Glu Pro Gly Leu 
        195                 200                 205             


Phe Lys Thr Asn Leu Ala Asp Pro Val Lys Val Ile Glu Lys Lys Leu 
    210                 215                 220                 


Ala Ile Trp Glu Gln Leu Ser Pro Asp Ile Lys Gln Gln Tyr Gly Glu 
225                 230                 235                 240 


Gly Tyr Ile Glu Lys Ser Leu Asp Lys Leu Lys Gly Asn Lys Ser Tyr 
                245                 250                 255     


Val Asn Met Asp Leu Ser Pro Val Val Glu Cys Met Asp His Ala Leu 
            260                 265                 270         


Thr Ser Leu Phe Pro Lys Thr His Tyr Ala Ala Gly Lys Asp Ala Lys 
        275                 280                 285             


Ile Phe Trp Ile Pro Leu Ser His Met Pro Ala Ala Leu Gln Asp Phe 
    290                 295                 300                 


Leu Leu Leu Lys Gln Lys Ala Glu Leu Ala Asn Pro Lys Ala Val 
305                 310                 315                 


<210>  1629
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  1629

Met Leu Phe Trp Val Leu Gly Leu Leu Ile Leu Cys Gly Phe Leu Trp 
1               5                   10                  15      


Thr Arg Lys Gly Lys Leu Lys Ile Glu Asp Ile Thr Asp Lys Tyr Ile 
            20                  25                  30          


Phe Ile Thr Gly Cys Asp Ser Gly Phe Gly Asn Leu Ala Ala Arg Thr 
        35                  40                  45              


Phe Asp Lys Lys Gly Phe His Val Ile Ala Ala Cys Leu Thr Glu Ser 
    50                  55                  60                  


Gly Ser Thr Ala Leu Lys Ala Glu Thr Ser Glu Arg Leu Arg Thr Val 
65                  70                  75                  80  


Leu Leu Asp Val Thr Asp Pro Glu Asn Val Lys Arg Thr Ala Gln Trp 
                85                  90                  95      


Val Lys Asn Gln Val Gly Glu Lys Gly Leu Trp Gly Leu Ile Asn Asn 
            100                 105                 110         


Ala Gly Val Pro Gly Val Leu Ala Pro Thr Asp Trp Leu Thr Leu Glu 
        115                 120                 125             


Asp Tyr Arg Glu Pro Ile Glu Val Asn Leu Phe Gly Leu Ile Ser Val 
    130                 135                 140                 


Thr Leu Asn Met Leu Pro Leu Val Lys Lys Ala Gln Gly Arg Val Ile 
145                 150                 155                 160 


Asn Val Ser Ser Val Gly Gly Arg Leu Ala Ile Val Gly Gly Gly Tyr 
                165                 170                 175     


Thr Pro Ser Lys Tyr Ala Val Glu Gly Phe Asn Asp Ser Leu Arg Arg 
            180                 185                 190         


Asp Met Lys Ala Phe Gly Val His Val Ser Cys Ile Glu Pro Gly Leu 
        195                 200                 205             


Phe Lys Thr Asn Leu Ala Asp Pro Val Lys Val Ile Glu Lys Lys Leu 
    210                 215                 220                 


Ala Ile Trp Glu Gln Leu Ser Pro Asp Ile Lys Gln Gln Tyr Gly Glu 
225                 230                 235                 240 


Gly Tyr Ile Glu Lys Ser Leu Asp Lys Leu Lys Gly Asn Lys Ser Tyr 
                245                 250                 255     


Val Asn Met Asp Leu Ser Pro Val Val Glu Cys Met Asp His Ala Leu 
            260                 265                 270         


Thr Ser Leu Phe Pro Lys Thr His Tyr Ala Ala Gly Lys Asp Ala Lys 
        275                 280                 285             


Ile Phe Trp Ile Pro Leu Ser His Met Pro Ala Ala Leu Gln Asp Phe 
    290                 295                 300                 


Leu Leu Leu Lys Gln Lys Ala Glu Leu Ala Asn Pro Lys Ala Val 
305                 310                 315                 


<210>  1630
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  1630

Met Ala Val Gly Gln Ile Gly Asn Phe Leu Ala Tyr Thr Ala Val Pro 
1               5                   10                  15      


Thr Val Leu Val Thr Pro Leu Gly Ala Leu Gly Val Pro Phe Gly Ser 
            20                  25                  30          


Ile Leu Ala Ser Tyr Leu Leu Lys Glu Lys Leu Asn Ile Leu Gly Lys 
        35                  40                  45              


Leu Gly Cys Leu Leu Ser Cys Ala Gly Ser Val Val Leu Ile Ile His 
    50                  55                  60                  


Ser Pro Lys Ser Glu Ser Val Thr Thr Gln Ala Glu Leu Glu Glu Lys 
65                  70                  75                  80  


Leu Thr Asn Pro Val Phe Val Gly Tyr Leu Cys Ile Val Leu Leu Met 
                85                  90                  95      


Leu Leu Leu Leu Ile Phe Trp Ile Ala Pro Ala His Gly Pro Thr Asn 
            100                 105                 110         


Ile Met Val Tyr Ile Ser Ile Cys Ser Leu Leu Gly Ser Phe Thr Val 
        115                 120                 125             


Pro Ser Thr Lys Gly Ile Gly Leu Ala Ala Gln Asp Ile Leu His Asn 
    130                 135                 140                 


Asn Pro Ser Ser Gln Arg Ala Leu Cys Leu Cys Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Gly Cys Ser Ile Ile Val Gln Phe Arg Tyr Ile Asn Lys Ala 
                165                 170                 175     


Leu Glu Cys Phe Asp Ser Ser Val Phe Gly Ala Ile Tyr Tyr Val Val 
            180                 185                 190         


Phe Thr Thr Leu Val Leu Leu Ala Ser Ala Ile Leu Phe Arg Glu Trp 
        195                 200                 205             


Ser Asn Val Gly Leu Val Asp Phe Leu Gly Met Ala Cys Gly Phe Thr 
    210                 215                 220                 


Thr Val Ser Val Gly Ile Val Leu Ile Gln Val Phe Lys Glu Phe Asn 
225                 230                 235                 240 


Phe Asn Leu Gly Glu Met Asn Lys Ser Asn Met Lys Thr Asp 
                245                 250                 


<210>  1631
<211>  751
<212>  PRT
<213>  Homo sapiens

<400>  1631

Met Ala Ala Thr Gly Thr Ala Ala Ala Ala Ala Thr Gly Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Gly Leu Thr Ala Pro Ala Leu Ala Leu Ala Gly 
            20                  25                  30          


Tyr Ile Glu Ala Leu Ala Ala Asn Ala Gly Thr Gly Phe Ala Val Ala 
        35                  40                  45              


Glu Pro Gln Ile Ala Met Phe Cys Gly Lys Leu Asn Met His Val Asn 
    50                  55                  60                  


Ile Gln Thr Gly Lys Trp Glu Pro Asp Pro Thr Gly Thr Lys Ser Cys 
65                  70                  75                  80  


Phe Glu Thr Lys Glu Glu Val Leu Gln Tyr Cys Gln Glu Met Tyr Pro 
                85                  90                  95      


Glu Leu Gln Ile Thr Asn Val Met Glu Ala Asn Gln Arg Val Ser Ile 
            100                 105                 110         


Asp Asn Trp Cys Arg Arg Asp Lys Lys Gln Cys Lys Ser Arg Phe Val 
        115                 120                 125             


Thr Pro Phe Lys Cys Leu Val Gly Glu Phe Val Ser Asp Val Leu Leu 
    130                 135                 140                 


Val Pro Glu Lys Cys Gln Phe Phe His Lys Glu Arg Met Glu Val Cys 
145                 150                 155                 160 


Glu Asn His Gln His Trp His Thr Val Val Lys Glu Ala Cys Leu Thr 
                165                 170                 175     


Gln Gly Met Thr Leu Tyr Ser Tyr Gly Met Leu Leu Pro Cys Gly Val 
            180                 185                 190         


Asp Gln Phe His Gly Thr Glu Tyr Val Cys Cys Pro Gln Thr Lys Ile 
        195                 200                 205             


Ile Gly Ser Val Ser Lys Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu 
    210                 215                 220                 


Glu Glu Glu Asp Glu Glu Glu Asp Tyr Asp Val Tyr Lys Ser Glu Phe 
225                 230                 235                 240 


Pro Thr Glu Ala Asp Leu Glu Asp Phe Thr Glu Ala Ala Val Asp Glu 
                245                 250                 255     


Asp Asp Glu Asp Glu Glu Glu Gly Glu Glu Val Val Glu Asp Arg Asp 
            260                 265                 270         


Tyr Tyr Tyr Asp Thr Phe Lys Gly Asp Asp Tyr Asn Glu Glu Asn Pro 
        275                 280                 285             


Thr Glu Pro Gly Ser Asp Gly Thr Met Ser Asp Lys Glu Ile Thr His 
    290                 295                 300                 


Asp Val Lys Ala Val Cys Ser Gln Glu Ala Met Thr Gly Pro Cys Arg 
305                 310                 315                 320 


Ala Val Met Pro Arg Trp Tyr Phe Asp Leu Ser Lys Gly Lys Cys Val 
                325                 330                 335     


Arg Phe Ile Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Glu Ser 
            340                 345                 350         


Glu Asp Tyr Cys Met Ala Val Cys Lys Ala Met Ile Pro Pro Thr Pro 
        355                 360                 365             


Leu Pro Thr Asn Asp Val Asp Val Tyr Phe Glu Thr Ser Ala Asp Asp 
    370                 375                 380                 


Asn Glu His Ala Arg Phe Gln Lys Ala Lys Glu Gln Leu Glu Ile Arg 
385                 390                 395                 400 


His Arg Asn Arg Met Asp Arg Val Lys Lys Glu Trp Glu Glu Ala Glu 
                405                 410                 415     


Leu Gln Ala Lys Asn Leu Pro Lys Ala Glu Arg Gln Thr Leu Ile Gln 
            420                 425                 430         


His Phe Gln Ala Met Val Lys Ala Leu Glu Lys Glu Ala Ala Ser Glu 
        435                 440                 445             


Lys Gln Gln Leu Val Glu Thr His Leu Ala Arg Val Glu Ala Met Leu 
    450                 455                 460                 


Asn Asp Arg Arg Arg Met Ala Leu Glu Asn Tyr Leu Ala Ala Leu Gln 
465                 470                 475                 480 


Ser Asp Pro Pro Arg Pro His Arg Ile Leu Gln Ala Leu Arg Arg Tyr 
                485                 490                 495     


Val Arg Ala Glu Asn Lys Asp Arg Leu His Thr Ile Arg His Tyr Gln 
            500                 505                 510         


His Val Leu Ala Val Asp Pro Glu Lys Ala Ala Gln Met Lys Ser Gln 
        515                 520                 525             


Val Met Thr His Leu His Val Ile Glu Glu Arg Arg Asn Gln Ser Leu 
    530                 535                 540                 


Ser Leu Leu Tyr Lys Val Pro Tyr Val Ala Gln Glu Ile Gln Glu Glu 
545                 550                 555                 560 


Ile Asp Glu Leu Leu Gln Glu Gln Arg Ala Asp Met Asp Gln Phe Thr 
                565                 570                 575     


Ala Ser Ile Ser Glu Thr Pro Val Asp Val Arg Val Ser Ser Glu Glu 
            580                 585                 590         


Ser Glu Glu Ile Pro Pro Phe His Pro Phe His Pro Phe Pro Ala Leu 
        595                 600                 605             


Pro Glu Asn Glu Gly Ser Gly Val Gly Glu Gln Asp Gly Gly Leu Ile 
    610                 615                 620                 


Gly Ala Glu Glu Lys Val Ile Asn Ser Lys Asn Lys Val Asp Glu Asn 
625                 630                 635                 640 


Met Val Ile Asp Glu Thr Leu Asp Val Lys Glu Met Ile Phe Asn Ala 
                645                 650                 655     


Glu Arg Val Gly Gly Leu Glu Glu Glu Arg Glu Ser Val Gly Pro Leu 
            660                 665                 670         


Arg Glu Asp Phe Ser Leu Ser Ser Ser Ala Leu Ile Gly Leu Leu Val 
        675                 680                 685             


Ile Ala Val Ala Ile Ala Thr Val Ile Val Ile Ser Leu Val Met Leu 
    690                 695                 700                 


Arg Lys Arg Gln Tyr Gly Thr Ile Ser His Gly Ile Val Glu Val Asp 
705                 710                 715                 720 


Pro Met Leu Thr Pro Glu Glu Arg His Leu Asn Lys Met Gln Asn His 
                725                 730                 735     


Gly Tyr Glu Asn Pro Thr Tyr Lys Tyr Leu Glu Gln Met Gln Ile 
            740                 745                 750     


<210>  1632
<211>  695
<212>  PRT
<213>  Homo sapiens

<400>  1632

Met Ala Ala Thr Gly Thr Ala Ala Ala Ala Ala Thr Gly Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Gly Leu Thr Ala Pro Ala Leu Ala Leu Ala Gly 
            20                  25                  30          


Tyr Ile Glu Ala Leu Ala Ala Asn Ala Gly Thr Gly Phe Ala Val Ala 
        35                  40                  45              


Glu Pro Gln Ile Ala Met Phe Cys Gly Lys Leu Asn Met His Val Asn 
    50                  55                  60                  


Ile Gln Thr Gly Lys Trp Glu Pro Asp Pro Thr Gly Thr Lys Ser Cys 
65                  70                  75                  80  


Phe Glu Thr Lys Glu Glu Val Leu Gln Tyr Cys Gln Glu Met Tyr Pro 
                85                  90                  95      


Glu Leu Gln Ile Thr Asn Val Met Glu Ala Asn Gln Arg Val Ser Ile 
            100                 105                 110         


Asp Asn Trp Cys Arg Arg Asp Lys Lys Gln Cys Lys Ser Arg Phe Val 
        115                 120                 125             


Thr Pro Phe Lys Cys Leu Val Gly Glu Phe Val Ser Asp Val Leu Leu 
    130                 135                 140                 


Val Pro Glu Lys Cys Gln Phe Phe His Lys Glu Arg Met Glu Val Cys 
145                 150                 155                 160 


Glu Asn His Gln His Trp His Thr Val Val Lys Glu Ala Cys Leu Thr 
                165                 170                 175     


Gln Gly Met Thr Leu Tyr Ser Tyr Gly Met Leu Leu Pro Cys Gly Val 
            180                 185                 190         


Asp Gln Phe His Gly Thr Glu Tyr Val Cys Cys Pro Gln Thr Lys Ile 
        195                 200                 205             


Ile Gly Ser Val Ser Lys Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu 
    210                 215                 220                 


Glu Glu Glu Asp Glu Glu Glu Asp Tyr Asp Val Tyr Lys Ser Glu Phe 
225                 230                 235                 240 


Pro Thr Glu Ala Asp Leu Glu Asp Phe Thr Glu Ala Ala Val Asp Glu 
                245                 250                 255     


Asp Asp Glu Asp Glu Glu Glu Gly Glu Glu Val Val Glu Asp Arg Asp 
            260                 265                 270         


Tyr Tyr Tyr Asp Thr Phe Lys Gly Asp Asp Tyr Asn Glu Glu Asn Pro 
        275                 280                 285             


Thr Glu Pro Gly Ser Asp Gly Thr Met Ser Asp Lys Glu Ile Thr His 
    290                 295                 300                 


Asp Val Lys Val Pro Pro Thr Pro Leu Pro Thr Asn Asp Val Asp Val 
305                 310                 315                 320 


Tyr Phe Glu Thr Ser Ala Asp Asp Asn Glu His Ala Arg Phe Gln Lys 
                325                 330                 335     


Ala Lys Glu Gln Leu Glu Ile Arg His Arg Asn Arg Met Asp Arg Val 
            340                 345                 350         


Lys Lys Glu Trp Glu Glu Ala Glu Leu Gln Ala Lys Asn Leu Pro Lys 
        355                 360                 365             


Ala Glu Arg Gln Thr Leu Ile Gln His Phe Gln Ala Met Val Lys Ala 
    370                 375                 380                 


Leu Glu Lys Glu Ala Ala Ser Glu Lys Gln Gln Leu Val Glu Thr His 
385                 390                 395                 400 


Leu Ala Arg Val Glu Ala Met Leu Asn Asp Arg Arg Arg Met Ala Leu 
                405                 410                 415     


Glu Asn Tyr Leu Ala Ala Leu Gln Ser Asp Pro Pro Arg Pro His Arg 
            420                 425                 430         


Ile Leu Gln Ala Leu Arg Arg Tyr Val Arg Ala Glu Asn Lys Asp Arg 
        435                 440                 445             


Leu His Thr Ile Arg His Tyr Gln His Val Leu Ala Val Asp Pro Glu 
    450                 455                 460                 


Lys Ala Ala Gln Met Lys Ser Gln Val Met Thr His Leu His Val Ile 
465                 470                 475                 480 


Glu Glu Arg Arg Asn Gln Ser Leu Ser Leu Leu Tyr Lys Val Pro Tyr 
                485                 490                 495     


Val Ala Gln Glu Ile Gln Glu Glu Ile Asp Glu Leu Leu Gln Glu Gln 
            500                 505                 510         


Arg Ala Asp Met Asp Gln Phe Thr Ala Ser Ile Ser Glu Thr Pro Val 
        515                 520                 525             


Asp Val Arg Val Ser Ser Glu Glu Ser Glu Glu Ile Pro Pro Phe His 
    530                 535                 540                 


Pro Phe His Pro Phe Pro Ala Leu Pro Glu Asn Glu Gly Ser Gly Val 
545                 550                 555                 560 


Gly Glu Gln Asp Gly Gly Leu Ile Gly Ala Glu Glu Lys Val Ile Asn 
                565                 570                 575     


Ser Lys Asn Lys Val Asp Glu Asn Met Val Ile Asp Glu Thr Leu Asp 
            580                 585                 590         


Val Lys Glu Met Ile Phe Asn Ala Glu Arg Val Gly Gly Leu Glu Glu 
        595                 600                 605             


Glu Arg Glu Ser Val Gly Pro Leu Arg Glu Asp Phe Ser Leu Ser Ser 
    610                 615                 620                 


Ser Ala Leu Ile Gly Leu Leu Val Ile Ala Val Ala Ile Ala Thr Val 
625                 630                 635                 640 


Ile Val Ile Ser Leu Val Met Leu Arg Lys Arg Gln Tyr Gly Thr Ile 
                645                 650                 655     


Ser His Gly Ile Val Glu Val Asp Pro Met Leu Thr Pro Glu Glu Arg 
            660                 665                 670         


His Leu Asn Lys Met Gln Asn His Gly Tyr Glu Asn Pro Thr Tyr Lys 
        675                 680                 685             


Tyr Leu Glu Gln Met Gln Ile 
    690                 695 


<210>  1633
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  1633

Met Ala Ala Thr Gly Thr Ala Ala Ala Ala Ala Thr Gly Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Gly Leu Thr Ala Pro Ala Leu Ala Leu Ala Gly 
            20                  25                  30          


Tyr Ile Glu Ala Leu Ala Ala Asn Ala Gly Thr Gly Phe Ala Val Ala 
        35                  40                  45              


Glu Pro Gln Ile Ala Met Phe Cys Gly Lys Leu Asn Met His Val Asn 
    50                  55                  60                  


Ile Gln Thr Gly Lys Trp Glu Pro Asp Pro Thr Gly Thr Lys Ser Cys 
65                  70                  75                  80  


Phe Glu Thr Lys Glu Glu Val Leu Gln Tyr Cys Gln Glu Met Tyr Pro 
                85                  90                  95      


Glu Leu Gln Ile Thr Asn Val Met Glu Ala Asn Gln Arg Val Ser Ile 
            100                 105                 110         


Asp Asn Trp Cys Arg Arg Asp Lys Lys Gln Cys Lys Ser Arg Phe Val 
        115                 120                 125             


Thr Pro Phe Lys Cys Leu Val Pro Pro Thr Pro Leu Pro Thr Asn Asp 
    130                 135                 140                 


Val Asp Val Tyr Phe Glu Thr Ser Ala Asp Asp Asn Glu His Ala Arg 
145                 150                 155                 160 


Phe Gln Lys Ala Lys Glu Gln Leu Glu Ile Arg His Arg Asn Arg Met 
                165                 170                 175     


Asp Arg Val Lys Lys Glu Trp Glu Glu Ala Glu Leu Gln Ala Lys Asn 
            180                 185                 190         


Leu Pro Lys Ala Glu Arg Gln Thr Leu Ile Gln His Phe Gln Ala Met 
        195                 200                 205             


Val Lys Ala Leu Glu Lys Glu Ala Ala Ser Glu Lys Gln Gln Leu Val 
    210                 215                 220                 


Glu Thr His Leu Ala Arg Val Glu Ala Met Leu Asn Asp Arg Arg Arg 
225                 230                 235                 240 


Met Ala Leu Glu Asn Tyr Leu Ala Ala Leu Gln Ser Asp Pro Pro Arg 
                245                 250                 255     


Pro His Arg Ile Leu Gln Ala Leu Arg Arg Tyr Val Arg Ala Glu Asn 
            260                 265                 270         


Lys Asp Arg Leu His Thr Ile Arg His Tyr Gln His Val Leu Ala Val 
        275                 280                 285             


Asp Pro Glu Lys Ala Ala Gln Met Lys Ser Gln Val Met Thr His Leu 
    290                 295                 300                 


His Val Ile Glu Glu Arg Arg Asn Gln Ser Leu Ser Leu Leu Tyr Lys 
305                 310                 315                 320 


Val Pro Tyr Val Ala Gln Glu Ile Gln Glu Glu Ile Asp Glu Leu Leu 
                325                 330                 335     


Gln Glu Gln Arg Ala Asp Met Asp Gln Phe Thr Ala Ser Ile Ser Glu 
            340                 345                 350         


Thr Pro Val Asp Val Arg Val Ser Ser Glu Glu Ser Glu Glu Ile Pro 
        355                 360                 365             


Pro Phe His Pro Phe His Pro Phe Pro Ala Leu Pro Glu Asn Glu Gly 
    370                 375                 380                 


Ser Gly Val Gly Glu Gln Asp Gly Gly Leu Ile Gly Ala Glu Glu Lys 
385                 390                 395                 400 


Val Ile Asn Ser Lys Asn Lys Val Asp Glu Asn Met Val Ile Asp Glu 
                405                 410                 415     


Thr Leu Asp Val Lys Glu Met Ile Phe Asn Ala Glu Arg Val Gly Gly 
            420                 425                 430         


Leu Glu Glu Glu Arg Glu Ser Val Gly Pro Leu Arg Glu Asp Phe Ser 
        435                 440                 445             


Leu Ser Ser Ser Ala Leu Ile Gly Leu Leu Val Ile Ala Val Ala Ile 
    450                 455                 460                 


Ala Thr Val Ile Val Ile Ser Leu Val Met Leu Arg Lys Arg Gln Tyr 
465                 470                 475                 480 


Gly Thr Ile Ser His Gly Ile Val Glu Val Asp Pro Met Leu Thr Pro 
                485                 490                 495     


Glu Glu Arg His Leu Asn Lys Met Gln Asn His Gly Tyr Glu Asn Pro 
            500                 505                 510         


Thr Tyr Lys Tyr Leu Glu Gln Met Gln Ile 
        515                 520         


<210>  1634
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  1634

Met Arg Met Cys Thr Pro Ile Arg Gly Leu Leu Met Ala Leu Ala Val 
1               5                   10                  15      


Met Phe Gly Thr Ala Met Ala Phe Ala Pro Ile Pro Arg Ile Thr Trp 
            20                  25                  30          


Glu His Arg Glu Val His Leu Val Gln Phe His Glu Pro Asp Ile Tyr 
        35                  40                  45              


Asn Tyr Ser Ala Leu Leu Leu Ser Glu Asp Lys Asp Thr Leu Tyr Ile 
    50                  55                  60                  


Gly Ala Arg Glu Ala Val Phe Ala Val Asn Ala Leu Asn Ile Ser Glu 
65                  70                  75                  80  


Lys Gln His Glu Val Tyr Trp Lys Val Ser Glu Asp Lys Lys Ala Lys 
                85                  90                  95      


Cys Ala Glu Lys Gly Lys Ser Lys Gln Thr Glu Cys Leu Asn Tyr Ile 
            100                 105                 110         


Arg Val Leu Gln Pro Leu Ser Ala Thr Ser Leu Tyr Val Cys Gly Thr 
        115                 120                 125             


Asn Ala Phe Gln Pro Ala Cys Asp His Leu Asn Leu Thr Ser Phe Lys 
    130                 135                 140                 


Phe Leu Gly Lys Asn Glu Asp Gly Lys Gly Arg Cys Pro Phe Asp Pro 
145                 150                 155                 160 


Ala His Ser Tyr Thr Ser Val Met Val Asp Gly Glu Leu Tyr Ser Gly 
                165                 170                 175     


Thr Ser Tyr Asn Phe Leu Gly Ser Glu Pro Ile Ile Ser Arg Asn Ser 
            180                 185                 190         


Ser His Ser Pro Leu Arg Thr Glu Tyr Ala Ile Pro Trp Leu Asn Glu 
        195                 200                 205             


Pro Ser Phe Val Phe Ala Asp Val Ile Arg Lys Ser Pro Asp Ser Pro 
    210                 215                 220                 


Asp Gly Glu Asp Asp Arg Val Tyr Phe Phe Phe Thr Glu Val Ser Val 
225                 230                 235                 240 


Glu Tyr Glu Phe Val Phe Arg Val Leu Ile Pro Arg Ile Ala Arg Val 
                245                 250                 255     


Cys Lys Gly Asp Gln Gly Gly Leu Arg Thr Leu Gln Lys Lys Trp Thr 
            260                 265                 270         


Ser Phe Leu Lys Ala Arg Leu Ile Cys Ser Arg Pro Asp Ser Gly Leu 
        275                 280                 285             


Val Phe Asn Val Leu Arg Asp Val Phe Val Leu Arg Ser Pro Gly Leu 
    290                 295                 300                 


Lys Val Pro Val Phe Tyr Ala Leu Phe Thr Pro Gln Leu Asn Asn Val 
305                 310                 315                 320 


Gly Leu Ser Ala Val Cys Ala Tyr Asn Leu Ser Thr Ala Glu Glu Val 
                325                 330                 335     


Phe Ser His Gly Lys Tyr Met Gln Ser Thr Thr Val Glu Gln Ser His 
            340                 345                 350         


Thr Lys Trp Val Arg Tyr Asn Gly Pro Val Pro Lys Pro Arg Pro Gly 
        355                 360                 365             


Ala Cys Ile Asp Ser Glu Ala Arg Ala Ala Asn Tyr Thr Ser Ser Leu 
    370                 375                 380                 


Asn Leu Pro Asp Lys Thr Leu Gln Phe Val Lys Asp His Pro Leu Met 
385                 390                 395                 400 


Asp Asp Ser Val Thr Pro Ile Asp Asn Arg Pro Arg Leu Ile Lys Lys 
                405                 410                 415     


Asp Val Asn Tyr Thr Gln Ile Val Val Asp Arg Thr Gln Ala Leu Asp 
            420                 425                 430         


Gly Thr Val Tyr Asp Val Met Phe Val Ser Thr Asp Arg Gly Ala Leu 
        435                 440                 445             


His Lys Ala Ile Ser Leu Glu His Ala Val His Ile Ile Glu Glu Thr 
    450                 455                 460                 


Gln Leu Phe Gln Asp Phe Glu Pro Val Gln Thr Leu Leu Leu Ser Ser 
465                 470                 475                 480 


Lys Lys Gly Asn Arg Phe Val Tyr Ala Gly Ser Asn Ser Gly Val Val 
                485                 490                 495     


Gln Ala Pro Leu Ala Phe Cys Gly Lys His Gly Thr Cys Glu Asp Cys 
            500                 505                 510         


Val Leu Ala Arg Asp Pro Tyr Cys Ala Trp Ser Pro Pro Thr Ala Thr 
        515                 520                 525             


Cys Val Ala Leu His Gln Thr Glu Ser Pro Ser Arg Gly Leu Ile Gln 
    530                 535                 540                 


Glu Met Ser Gly Asp Ala Ser Val Cys Pro Ala Ser Ser Pro Lys Pro 
545                 550                 555                 560 


Leu Pro Pro Pro Gly Ser Ser Ser Leu Ser Cys Leu Gly His Val Gly 
                565                 570                 575     


Asp Arg Arg Leu Ser Ser Pro Trp Thr Pro Trp Pro Ala Ser Gly Ala 
            580                 585                 590         


Gly Pro Asp Ser Ser Ser Arg Val Ser Leu Leu Pro Pro Phe Leu Ser 
        595                 600                 605             


Asp Gln Ala Gln His Val His Ala Leu Gly Asn Phe Tyr Leu Phe Cys 
    610                 615                 620                 


Gln Ala Thr Gly Pro Ala Asp Ile Arg Phe Val Trp Glu Lys Asn Gly 
625                 630                 635                 640 


Arg Ala Leu Glu Thr Cys Val Pro Val Gln Thr His Ala Leu Pro Asp 
                645                 650                 655     


Gly Arg Ala His Ala Leu Ser Trp Leu Gln Asp Ala Ile Arg Glu Ser 
            660                 665                 670         


Ala Glu Tyr Arg Cys Ser Val Leu Ser Ser Ala Gly Asn Lys Thr Ser 
        675                 680                 685             


Lys Val Gln Val Ala Val Met Arg Pro Glu Val Thr His Gln Glu Arg 
    690                 695                 700                 


Trp Thr Arg Glu Leu Ser Ala Trp Arg Ala Val Ala Gly Glu His Asp 
705                 710                 715                 720 


Arg Met Met Gln Ser Trp Arg Lys Ala Trp Glu Ser Cys Ser Lys Asp 
                725                 730                 735     


Thr Leu 
        


<210>  1635
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  1635

Met Ala Ala Thr Leu Gly Pro Leu Gly Ser Trp Gln Gln Trp Arg Arg 
1               5                   10                  15      


Cys Leu Ser Ala Arg Asp Gly Ser Arg Met Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Gly Ser Gly Gln Gly Pro Gln Gln Val Gly Ala Gly Gln Thr Phe 
        35                  40                  45              


Glu Tyr Leu Lys Arg Glu His Ser Leu Ser Lys Pro Tyr Gln Gly Val 
    50                  55                  60                  


Gly Thr Gly Ser Ser Ser Leu Trp Asn Leu Met Gly Asn Ala Met Val 
65                  70                  75                  80  


Met Thr Gln Tyr Ile Arg Leu Thr Pro Asp Met Gln Ser Lys Gln Gly 
                85                  90                  95      


Ala Leu Trp Asn Arg Val Pro Cys Phe Leu Arg Asp Trp Glu Leu Gln 
            100                 105                 110         


Val His Phe Lys Ile His Gly Gln Gly Lys Lys Asn Leu His Gly Asp 
        115                 120                 125             


Gly Leu Ala Ile Trp Tyr Thr Lys Asp Arg Met Gln Pro Gly Pro Val 
    130                 135                 140                 


Phe Gly Asn Met Asp Lys Phe Val Gly Leu Gly Val Phe Val Asp Thr 
145                 150                 155                 160 


Tyr Pro Asn Glu Glu Lys Gln Gln Glu Ala Gln Lys Arg Arg Tyr Ser 
                165                 170                 175     


Pro Gly Val Gln Arg Val Phe Pro Tyr Ile Ser Ala Met Val Asn Asn 
            180                 185                 190         


Gly Ser Leu Ser Tyr Asp His Glu Arg Asp Gly Arg Pro Thr Glu Leu 
        195                 200                 205             


Gly Gly Cys Thr Ala Ile Val Arg Asn Leu His Tyr Asp Thr Phe Leu 
    210                 215                 220                 


Val Ile Arg Tyr Val Lys Arg His Leu Thr Ile Met Met Asp Ile Asp 
225                 230                 235                 240 


Gly Lys His Glu Trp Arg Asp Cys Ile Glu Val Pro Gly Val Arg Leu 
                245                 250                 255     


Pro Arg Gly Tyr Tyr Phe Gly Thr Ser Ser Ile Thr Gly Asp Leu Ser 
            260                 265                 270         


Asp Asn His Asp Val Ile Ser Leu Lys Leu Phe Glu Leu Thr Val Glu 
        275                 280                 285             


Arg Thr Pro Glu Glu Glu Lys Leu His Arg Asp Val Phe Leu Pro Ser 
    290                 295                 300                 


Val Asp Asn Met Lys Leu Pro Glu Met Thr Ala Pro Leu Pro Pro Leu 
305                 310                 315                 320 


Ser Gly Leu Ala Leu Phe Leu Ile Val Phe Phe Ser Leu Val Phe Ser 
                325                 330                 335     


Val Phe Ala Ile Val Ile Gly Ile Ile Leu Tyr Asn Lys Trp Gln Glu 
            340                 345                 350         


Gln Ser Arg Lys Arg Phe Tyr 
        355                 


<210>  1636
<211>  914
<212>  PRT
<213>  Homo sapiens

<400>  1636

Met Ser Leu Ser His Trp Pro Tyr Phe Arg Leu Val Leu Asn Phe Arg 
1               5                   10                  15      


Pro Gln Val Ile Cys Leu Pro Gln Pro Pro Lys Val Leu Gly Tyr Arg 
            20                  25                  30          


Leu Glu Pro Pro His Leu Thr Leu Ala Cys Thr Leu Glu Gly Met Tyr 
        35                  40                  45              


Asn Ile Ile Glu Glu Ile Leu Glu Arg Asp Ile Asn Gly Thr Leu Leu 
    50                  55                  60                  


Ser Gln Ala Thr Cys Glu Leu Cys Asp Gly Asn Glu Asn Ser Phe Met 
65                  70                  75                  80  


Val Val Asn Ala Leu Gly Asp Arg Cys Val Arg Cys Glu Pro Thr Phe 
                85                  90                  95      


Val Asn Thr Ser Arg Ser Cys Ala Cys Ser Glu Pro Asn Ile Leu Thr 
            100                 105                 110         


Gly Gly Leu Cys Phe Ser Ser Thr Gly Asn Phe Pro Leu Arg Arg Ile 
        115                 120                 125             


Ser Ala Ala Arg Tyr Gly Glu Val Gly Met Ser Leu Thr Ser Glu Trp 
    130                 135                 140                 


Phe Ala Lys Tyr Leu Gln Ser Ser Ala Ala Ala Cys Trp Val Tyr Ala 
145                 150                 155                 160 


Asn Leu Thr Ser Cys Gln Ala Leu Gly Asn Met Cys Val Met Asn Met 
                165                 170                 175     


Asn Ser Tyr Asp Phe Ala Thr Phe Asp Ala Cys Gly Leu Phe Gln Phe 
            180                 185                 190         


Ile Phe Glu Asn Thr Ala Gly Leu Ser Thr Val His Ser Ile Ser Phe 
        195                 200                 205             


Trp Arg Gln Asn Leu Pro Trp Leu Phe Tyr Gly Asp Gln Leu Gly Leu 
    210                 215                 220                 


Ala Pro Gln Val Leu Ser Ser Thr Ser Leu Pro Thr Asn Phe Ser Phe 
225                 230                 235                 240 


Lys Gly Glu Asn Gln Asn Thr Lys Leu Lys Phe Val Ala Ala Ser Tyr 
                245                 250                 255     


Asp Ile Arg Gly Asn Phe Leu Lys Trp Gln Thr Leu Glu Gly Gly Val 
            260                 265                 270         


Leu Gln Leu Cys Pro Asp Thr Glu Thr Arg Leu Asn Ala Ala Tyr Ser 
        275                 280                 285             


Phe Gly Thr Thr Tyr Gln Gln Asn Cys Glu Ile Pro Ile Ser Lys Ile 
    290                 295                 300                 


Leu Ile Asp Phe Pro Thr Pro Ile Phe Tyr Asp Val Tyr Leu Glu Tyr 
305                 310                 315                 320 


Thr Asp Glu Asn Gln His Gln Tyr Ile Leu Ala Val Pro Val Leu Asn 
                325                 330                 335     


Leu Asn Leu Gln His Asn Lys Ile Phe Val Asn Gln Asp Ser Asn Ser 
            340                 345                 350         


Gly Lys Trp Leu Leu Thr Arg Arg Ile Phe Leu Val Asp Ala Val Ser 
        355                 360                 365             


Gly Arg Glu Asn Asp Leu Gly Thr Gln Pro Arg Val Ile Arg Val Ala 
    370                 375                 380                 


Thr Gln Ile Ser Leu Ser Val His Leu Val Pro Asn Thr Ile Asn Gly 
385                 390                 395                 400 


Asn Ile Tyr Pro Pro Leu Ile Thr Ile Ala Tyr Ser Asp Ile Asp Ile 
                405                 410                 415     


Lys Asp Ala Asn Ser Gln Ser Val Lys Val Ser Phe Ser Val Thr Tyr 
            420                 425                 430         


Glu Met Asp His Gly Glu Ala His Val Gln Thr Asp Ile Ala Leu Gly 
        435                 440                 445             


Val Leu Gly Gly Leu Ala Val Leu Ala Ser Leu Leu Lys Thr Ala Gly 
    450                 455                 460                 


Trp Lys Arg Arg Ile Gly Ser Pro Met Ile Asp Leu Gln Thr Val Val 
465                 470                 475                 480 


Lys Phe Leu Val Tyr Tyr Ala Gly Asp Leu Ala Asn Val Phe Phe Ile 
                485                 490                 495     


Ile Thr Val Gly Thr Gly Leu Tyr Trp Leu Ile Phe Phe Lys Ala Gln 
            500                 505                 510         


Lys Ser Val Ser Val Leu Leu Pro Met Pro Ile Gln Glu Glu Arg Phe 
        515                 520                 525             


Val Thr Tyr Val Gly Cys Ala Phe Ala Leu Lys Ala Leu Gln Phe Leu 
    530                 535                 540                 


His Lys Leu Ile Ser Gln Ile Thr Ile Asp Val Phe Phe Ile Asp Trp 
545                 550                 555                 560 


Glu Arg Pro Lys Gly Lys Val Leu Lys Ala Val Glu Gly Glu Gly Gly 
                565                 570                 575     


Val Arg Ser Ala Thr Val Pro Val Ser Ile Trp Arg Thr Tyr Phe Val 
            580                 585                 590         


Ala Asn Glu Trp Asn Glu Ile Gln Thr Val Arg Lys Ile Asn Ser Leu 
        595                 600                 605             


Phe Gln Val Leu Thr Val Leu Phe Phe Leu Glu Val Val Gly Phe Lys 
    610                 615                 620                 


Asn Leu Ala Leu Met Asp Ser Ser Ser Ser Leu Ser Arg Asn Pro Pro 
625                 630                 635                 640 


Ser Tyr Ile Ala Pro Tyr Ser Cys Ile Leu Arg Tyr Ala Val Ser Ala 
                645                 650                 655     


Ala Leu Trp Leu Ala Ile Gly Ile Ile Gln Val Val Phe Phe Ala Val 
            660                 665                 670         


Phe Tyr Glu Arg Phe Ile Glu Asp Lys Ile Arg Gln Phe Val Asp Leu 
        675                 680                 685             


Cys Ser Met Ser Asn Ile Ser Val Phe Leu Leu Ser His Lys Cys Phe 
    690                 695                 700                 


Gly Tyr Tyr Ile His Gly Arg Ser Val His Gly His Ala Asp Thr Asn 
705                 710                 715                 720 


Met Glu Glu Met Asn Met Asn Leu Lys Arg Glu Ala Glu Asn Leu Cys 
                725                 730                 735     


Ser Gln Arg Gly Leu Val Pro Asn Thr Asp Gly Gln Thr Phe Glu Ile 
            740                 745                 750         


Ala Ile Ser Asn Gln Met Arg Gln His Tyr Asp Arg Ile His Glu Thr 
        755                 760                 765             


Leu Ile Arg Lys Asn Gly Pro Ala Arg Leu Leu Ser Ser Ser Ala Ser 
    770                 775                 780                 


Thr Phe Glu Gln Ser Ile Lys Ala Tyr His Met Met Asn Lys Phe Leu 
785                 790                 795                 800 


Gly Ser Phe Ile Asp His Val His Lys Glu Met Asp Tyr Phe Ile Lys 
                805                 810                 815     


Asp Lys Leu Leu Leu Glu Arg Ile Leu Gly Met Glu Phe Met Glu Pro 
            820                 825                 830         


Met Glu Lys Ser Ile Phe Tyr Asn Asp Glu Gly Tyr Ser Phe Ser Ser 
        835                 840                 845             


Val Leu Tyr Tyr Gly Asn Glu Ala Thr Leu Leu Ile Phe Asp Leu Leu 
    850                 855                 860                 


Phe Phe Cys Val Val Asp Leu Ala Cys Gln Asn Phe Ile Leu Ala Ser 
865                 870                 875                 880 


Phe Leu Thr Tyr Leu Gln Gln Glu Ile Phe Arg Tyr Ile Arg Asn Thr 
                885                 890                 895     


Val Gly Gln Lys Asn Leu Ala Ser Lys Thr Leu Val Asp Gln Arg Phe 
            900                 905                 910         


Leu Ile 
        


<210>  1637
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  1637

Met Asp Thr Glu Ser Asn Arg Arg Ala Asn Leu Ala Leu Pro Gln Glu 
1               5                   10                  15      


Pro Ser Ser Val Pro Ala Phe Glu Val Leu Glu Ile Ser Pro Gln Glu 
            20                  25                  30          


Val Ser Ser Gly Arg Leu Leu Lys Ser Ala Ser Ser Pro Pro Leu His 
        35                  40                  45              


Thr Trp Leu Thr Val Leu Lys Lys Glu Gln Glu Phe Leu Gly Val Thr 
    50                  55                  60                  


Gln Ile Leu Thr Ala Met Ile Cys Leu Cys Phe Gly Thr Val Val Cys 
65                  70                  75                  80  


Ser Val Leu Asp Ile Ser His Ile Glu Gly Asp Ile Phe Ser Ser Phe 
                85                  90                  95      


Lys Ala Gly Tyr Pro Phe Trp Gly Ala Ile Phe Phe Ser Ile Ser Gly 
            100                 105                 110         


Met Leu Ser Ile Ile Ser Glu Arg Arg Asn Ala Thr Tyr Leu Val Arg 
        115                 120                 125             


Gly Ser Leu Gly Ala Asn Thr Ala Ser Ser Ile Ala Gly Gly Thr Gly 
    130                 135                 140                 


Ile Thr Ile Leu Ile Ile Asn Leu Lys Lys Ser Leu Ala Tyr Ile His 
145                 150                 155                 160 


Ile His Ser Cys Gln Lys Phe Phe Glu Thr Lys Cys Phe Met Ala Ser 
                165                 170                 175     


Phe Ser Thr Glu Ile Val Val Met Met Leu Phe Leu Thr Ile Leu Gly 
            180                 185                 190         


Leu Gly Ser Ala Val Ser Leu Thr Ile Cys Gly Ala Gly Glu Glu Leu 
        195                 200                 205             


Lys Gly Asn Lys Val Pro Glu Asp Arg Val Tyr Glu Glu Leu Asn Ile 
    210                 215                 220                 


Tyr Ser Ala Thr Tyr Ser Glu Leu Glu Asp Pro Gly Glu Met Ser Pro 
225                 230                 235                 240 


Pro Ile Asp Leu 
                


<210>  1638
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  1638

Met Glu Glu Pro Thr Ala Val Glu Gly Gln Val Gln Leu Pro Ser Pro 
1               5                   10                  15      


His Gln Gly Ser Leu Arg Lys Ala Val Ala Ala Ala Leu Ala Leu Asp 
            20                  25                  30          


Gly Glu Ser Thr Met Gly His Arg Lys Lys Lys Arg Lys Glu Ser Arg 
        35                  40                  45              


Pro Glu Ser Ile Ile Ile Tyr Arg Ser Asp Asn Glu Lys Thr Asp Glu 
    50                  55                  60                  


Glu Pro Gly Glu Ser Glu Gly Gly Asp Gln Pro Lys Glu Glu Glu Gly 
65                  70                  75                  80  


Asp Asp Phe Leu Asp Tyr Pro Val Asp Asp Asp Met Trp Asn Leu Pro 
                85                  90                  95      


Leu Asp Ser Arg Tyr Val Thr Leu Thr Gly Thr Ile Thr Arg Gly Lys 
            100                 105                 110         


Lys Lys Gly Gln Met Val Asp Ile His Val Thr Leu Thr Glu Lys Glu 
        115                 120                 125             


Leu Gln Glu Leu Thr Lys Pro Lys Glu Ser Ser Arg Glu Thr Thr Pro 
    130                 135                 140                 


Glu Gly Arg Met Ala Cys Gln Met Gly Ala Asp Arg Gly Pro His Val 
145                 150                 155                 160 


Val Leu Trp Thr Leu Ile Cys Leu Pro Val Val Phe Ile Leu Ser Phe 
                165                 170                 175     


Val Val Ser Phe Tyr Tyr Gly Thr Ile Thr Trp Tyr Asn Ile Phe Leu 
            180                 185                 190         


Val Tyr Asn Glu Glu Arg Thr Phe Trp His Lys Ile Ser Tyr Cys Pro 
        195                 200                 205             


Cys Leu Val Leu Phe Tyr Pro Val Leu Ile Met Ala Met Ala Ser Ser 
    210                 215                 220                 


Leu Gly Leu Tyr Ala Ala Val Val Gln Leu Ser Trp Ser Trp Glu Ala 
225                 230                 235                 240 


Trp Trp Gln Ala Ala Arg Asp Met Glu Lys Gly Phe Cys Gly Trp Leu 
                245                 250                 255     


Cys Ser Lys Leu Gly Leu Glu Asp Cys Ser Pro Tyr Ser Ile Val Glu 
            260                 265                 270         


Leu Leu Glu Ser Asp Asn Ile Ser Ser Thr Leu Ser Asn Lys Asp Pro 
        275                 280                 285             


Ile Gln Glu Val Glu Thr Ser Thr Val 
    290                 295         


<210>  1639
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  1639

Met Glu Glu Pro Thr Ala Val Glu Gly Gln Val Gln Leu Pro Ser Pro 
1               5                   10                  15      


His Gln Gly Ser Leu Arg Lys Ala Val Ala Ala Ala Leu Ala Leu Asp 
            20                  25                  30          


Gly Glu Ser Thr Met Gly His Arg Lys Lys Lys Arg Lys Glu Ser Arg 
        35                  40                  45              


Pro Glu Ser Ile Ile Ile Tyr Arg Ser Asp Asn Glu Lys Thr Asp Glu 
    50                  55                  60                  


Glu Pro Gly Glu Ser Glu Gly Gly Asp Gln Pro Lys Glu Glu Glu Gly 
65                  70                  75                  80  


Asp Asp Phe Leu Asp Tyr Pro Val Asp Asp Asp Met Trp Asn Leu Pro 
                85                  90                  95      


Leu Asp Ser Arg Tyr Val Thr Leu Thr Gly Thr Ile Thr Arg Gly Lys 
            100                 105                 110         


Lys Lys Gly Gln Met Val Asp Ile His Val Thr Leu Thr Glu Lys Glu 
        115                 120                 125             


Leu Gln Glu Leu Thr Lys Pro Lys Glu Ser Ser Arg Glu Thr Thr Pro 
    130                 135                 140                 


Glu Gly Arg Met Ala Cys Gln Met Gly Ala Asp Arg Gly Pro His Val 
145                 150                 155                 160 


Val Leu Trp Thr Leu Ile Cys Leu Pro Val Val Phe Ile Leu Ser Phe 
                165                 170                 175     


Val Val Ser Phe Tyr Tyr Gly Thr Ile Thr Trp Tyr Asn Ile Phe Leu 
            180                 185                 190         


Val Tyr Asn Glu Glu Arg Thr Phe Trp His Lys Ile Ser Tyr Cys Pro 
        195                 200                 205             


Cys Leu Val Leu Phe Tyr Pro Val Leu Ile Met Ala Met Ala Ser Ser 
    210                 215                 220                 


Leu Gly Leu Tyr Ala Ala Val Val Gln Leu Ser Trp Ser Trp Glu Ala 
225                 230                 235                 240 


Trp Trp Gln Ala Ala Arg Asp Met Glu Lys Gly Phe Cys Gly Trp Leu 
                245                 250                 255     


Cys Ser Lys Leu Gly Leu Glu Asp Cys Ser Pro Tyr Ser Ile Val Glu 
            260                 265                 270         


Leu Leu Glu Ser Asp Asn Ile Ser Ser Thr Leu Ser Asn Lys Asp Pro 
        275                 280                 285             


Ile Gln Glu Val Glu Thr Ser Thr Val 
    290                 295         


<210>  1640
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  1640

Met Glu Glu Pro Thr Ala Val Glu Gly Gln Val Gln Leu Pro Ser Pro 
1               5                   10                  15      


His Gln Gly Ser Leu Arg Lys Ala Val Ala Ala Ala Leu Ala Leu Asp 
            20                  25                  30          


Gly Glu Ser Thr Met Gly His Arg Lys Lys Lys Arg Lys Glu Ser Arg 
        35                  40                  45              


Pro Glu Ser Ile Ile Ile Tyr Arg Ser Asp Asn Glu Lys Thr Asp Glu 
    50                  55                  60                  


Glu Pro Gly Glu Ser Glu Gly Gly Asp Gln Pro Lys Glu Glu Glu Gly 
65                  70                  75                  80  


Asp Asp Phe Leu Asp Tyr Pro Val Asp Asp Asp Met Trp Asn Leu Pro 
                85                  90                  95      


Leu Asp Ser Arg Tyr Val Thr Leu Thr Gly Thr Ile Thr Arg Gly Lys 
            100                 105                 110         


Lys Lys Gly Gln Met Val Asp Ile His Val Thr Leu Thr Glu Lys Glu 
        115                 120                 125             


Leu Gln Glu Leu Thr Lys Pro Lys Glu Ser Ser Arg Glu Thr Thr Pro 
    130                 135                 140                 


Glu Gly Arg Met Ala Cys Gln Met Gly Ala Asp Arg Gly Pro His Val 
145                 150                 155                 160 


Val Leu Trp Thr Leu Ile Cys Leu Pro Val Val Phe Ile Leu Ser Phe 
                165                 170                 175     


Val Val Ser Phe Tyr Tyr Gly Thr Ile Thr Trp Tyr Asn Ile Phe Leu 
            180                 185                 190         


Val Tyr Asn Glu Glu Arg Thr Phe Trp His Lys Ile Ser Tyr Cys Pro 
        195                 200                 205             


Cys Leu Val Leu Phe Tyr Pro Val Leu Ile Met Ala Met Ala Ser Ser 
    210                 215                 220                 


Leu Gly Leu Tyr Ala Ala Val Val Gln Leu Ser Trp Ser Trp Glu Ala 
225                 230                 235                 240 


Trp Trp Gln Ala Ala Arg Asp Met Glu Lys Gly Phe Cys Gly Trp Leu 
                245                 250                 255     


Cys Ser Lys Leu Gly Leu Glu Asp Cys Ser Pro Tyr Ser Ile Val Glu 
            260                 265                 270         


Leu Leu Glu Ser Asp Asn Ile Ser Ser Thr Leu Ser Asn Lys Asp Pro 
        275                 280                 285             


Ile Gln Glu Val Glu Thr Ser Thr Val 
    290                 295         


<210>  1641
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  1641

Met Leu Arg Thr Ile Leu Asp Ala Pro Gln Arg Leu Leu Lys Glu Gly 
1               5                   10                  15      


Arg Ala Ser Arg Gln Leu Val Leu Val Val Val Phe Val Ala Leu Leu 
            20                  25                  30          


Leu Asp Asn Met Leu Phe Thr Val Val Val Pro Ile Val Pro Thr Phe 
        35                  40                  45              


Leu Tyr Asp Met Glu Phe Lys Glu Val Asn Ser Ser Leu His Leu Gly 
    50                  55                  60                  


His Ala Gly Ser Ser Pro His Ala Leu Ala Ser Pro Ala Phe Ser Thr 
65                  70                  75                  80  


Ile Phe Ser Phe Phe Asn Asn Asn Thr Val Ala Val Glu Glu Ser Val 
                85                  90                  95      


Pro Ser Gly Ile Ala Trp Met Asn Asp Thr Ala Ser Thr Ile Pro Pro 
            100                 105                 110         


Pro Ala Thr Glu Ala Ile Ser Ala His Lys Asn Asn Cys Leu Gln Gly 
        115                 120                 125             


Thr Gly Phe Leu Glu Glu Glu Ile Thr Arg Val Gly Val Leu Phe Ala 
    130                 135                 140                 


Ser Lys Ala Val Met Gln Leu Leu Val Asn Pro Phe Val Gly Pro Leu 
145                 150                 155                 160 


Thr Asn Arg Ile Gly Tyr His Ile Pro Met Phe Ala Gly Phe Val Ile 
                165                 170                 175     


Met Phe Leu Ser Thr Val Met Phe Ala Phe Ser Gly Thr Tyr Thr Leu 
            180                 185                 190         


Leu Phe Val Ala Arg Thr Leu Gln Gly Ile Gly Ser Ser Phe Ser Ser 
        195                 200                 205             


Val Ala Gly Leu Gly Met Leu Ala Ser Val Tyr Thr Asp Asp His Glu 
    210                 215                 220                 


Arg Gly Arg Ala Met Gly Thr Ala Leu Gly Gly Leu Ala Leu Gly Leu 
225                 230                 235                 240 


Leu Val Gly Ala Pro Phe Gly Ser Val Met Tyr Glu Phe Val Gly Lys 
                245                 250                 255     


Ser Ala Pro Phe Leu Ile Leu Ala Phe Leu Ala Leu Leu Asp Gly Ala 
            260                 265                 270         


Leu Gln Leu Cys Ile Leu Gln Pro Ser Lys Val Ser Pro Glu Ser Ala 
        275                 280                 285             


Lys Gly Thr Pro Leu Phe Met Leu Leu Lys Asp Pro Tyr Ile Leu Val 
    290                 295                 300                 


Ala Ala Gly Leu Ala Phe Leu Pro Ala Ser Val Ser Tyr Leu Ile Gly 
305                 310                 315                 320 


Thr Asn Leu Phe Gly Val Leu Ala Asn Lys Met Gly Arg Trp Leu Cys 
                325                 330                 335     


Ser Leu Ile Gly Met Leu Val Val Gly Thr Ser Leu Leu Cys Val Pro 
            340                 345                 350         


Leu Ala His Asn Ile Phe Gly Leu Ile Gly Pro Asn Ala Gly Leu Gly 
        355                 360                 365             


Leu Ala Ile Gly Met Val Asp Ser Ser Met Met Pro Ile Met Gly His 
    370                 375                 380                 


Leu Val Asp Leu Arg His Thr Ser Val Tyr Gly Ser Val Tyr Ala Ile 
385                 390                 395                 400 


Ala Asp Val Ala Phe Cys Met Gly Phe Ala Ile Gly Pro Ser Thr Gly 
                405                 410                 415     


Gly Ala Ile Val Lys Ala Ile Gly Phe Pro Trp Leu Met Val Ile Thr 
            420                 425                 430         


Gly Val Ile Asn Ile Val Tyr Ala Pro Leu Cys Tyr Tyr Leu Arg Ser 
        435                 440                 445             


Pro Pro Ala Lys Glu Glu Lys Leu Ala Ile Leu Ser Gln Asp Cys Pro 
    450                 455                 460                 


Met Glu Thr Arg Met Tyr Ala Thr Gln Lys Pro Thr Lys Glu Phe Pro 
465                 470                 475                 480 


Leu Gly Glu Asp Ser Asp Glu Glu Pro Asp His Glu Glu 
                485                 490             


<210>  1642
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  1642

Met Leu Arg Thr Ile Leu Asp Ala Pro Gln Arg Leu Leu Lys Glu Gly 
1               5                   10                  15      


Arg Ala Ser Arg Gln Leu Val Leu Val Val Val Phe Val Ala Leu Leu 
            20                  25                  30          


Leu Asp Asn Met Leu Phe Thr Val Val Val Pro Ile Val Pro Thr Phe 
        35                  40                  45              


Leu Tyr Asp Met Glu Phe Lys Glu Val Asn Ser Ser Leu His Leu Gly 
    50                  55                  60                  


His Ala Gly Ser Ser Pro His Ala Leu Ala Ser Pro Ala Phe Ser Thr 
65                  70                  75                  80  


Ile Phe Ser Phe Phe Asn Asn Asn Thr Val Ala Val Glu Glu Ser Val 
                85                  90                  95      


Pro Ser Gly Ile Ala Trp Met Asn Asp Thr Ala Ser Thr Ile Pro Pro 
            100                 105                 110         


Pro Ala Thr Glu Ala Ile Ser Ala His Lys Asn Asn Cys Leu Gln Gly 
        115                 120                 125             


Thr Gly Phe Leu Glu Glu Glu Ile Thr Arg Val Gly Val Leu Phe Ala 
    130                 135                 140                 


Ser Lys Ala Val Met Gln Leu Leu Val Asn Pro Phe Val Gly Pro Leu 
145                 150                 155                 160 


Thr Asn Arg Ile Gly Tyr His Ile Pro Met Phe Ala Gly Phe Val Ile 
                165                 170                 175     


Met Phe Leu Ser Thr Val Met Phe Ala Phe Ser Gly Thr Tyr Thr Leu 
            180                 185                 190         


Leu Phe Val Ala Arg Thr Leu Gln Gly Ile Gly Ser Ser Phe Ser Ser 
        195                 200                 205             


Val Ala Gly Leu Gly Met Leu Ala Ser Val Tyr Thr Asp Asp His Glu 
    210                 215                 220                 


Arg Gly Arg Ala Met Gly Thr Ala Leu Gly Gly Leu Ala Leu Gly Leu 
225                 230                 235                 240 


Leu Val Gly Ala Pro Phe Gly Ser Val Met Tyr Glu Phe Val Gly Lys 
                245                 250                 255     


Ser Ala Pro Phe Leu Ile Leu Ala Phe Leu Ala Leu Leu Asp Gly Ala 
            260                 265                 270         


Leu Gln Leu Cys Ile Leu Gln Pro Ser Lys Val Ser Pro Glu Ser Ala 
        275                 280                 285             


Lys Gly Thr Pro Leu Phe Met Leu Leu Lys Asp Pro Tyr Ile Leu Val 
    290                 295                 300                 


Ala Ala Gly Ser Ile Cys Phe Ala Asn Met Gly Val Ala Ile Leu Glu 
305                 310                 315                 320 


Pro Thr Leu Pro Ile Trp Met Met Gln Thr Met Cys Ser Pro Lys Trp 
                325                 330                 335     


Gln Leu Gly Leu Ala Phe Leu Pro Ala Ser Val Ser Tyr Leu Ile Gly 
            340                 345                 350         


Thr Asn Leu Phe Gly Val Leu Ala Asn Lys Met Gly Arg Trp Leu Cys 
        355                 360                 365             


Ser Leu Ile Gly Met Leu Val Val Gly Thr Ser Leu Leu Cys Val Pro 
    370                 375                 380                 


Leu Ala His Asn Ile Phe Gly Leu Ile Gly Pro Asn Ala Gly Leu Gly 
385                 390                 395                 400 


Leu Ala Ile Gly Met Val Asp Ser Ser Met Met Pro Ile Met Gly His 
                405                 410                 415     


Leu Val Asp Leu Arg His Thr Ser Val Tyr Gly Ser Val Tyr Ala Ile 
            420                 425                 430         


Ala Asp Val Ala Phe Cys Met Gly Phe Ala Ile Gly Tyr Ser Glu Ser 
        435                 440                 445             


Gly Leu Pro His Gly Asp Pro Asp Val Cys Asn Pro Glu Ala His Glu 
    450                 455                 460                 


Gly Ile Ser Ser Gly Gly Gly Gln 
465                 470         


<210>  1643
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  1643

Met Arg Met Glu Asp Glu Asp Tyr Asn Thr Ser Ile Ser Tyr Gly Asp 
1               5                   10                  15      


Glu Tyr Pro Asp Tyr Leu Asp Ser Ile Val Val Leu Glu Asp Leu Ser 
            20                  25                  30          


Pro Leu Glu Ala Arg Val Thr Arg Ile Phe Leu Val Val Val Tyr Ser 
        35                  40                  45              


Ile Val Cys Phe Leu Gly Ile Leu Gly Asn Gly Leu Val Ile Ile Ile 
    50                  55                  60                  


Ala Thr Phe Lys Met Lys Lys Thr Val Asn Met Val Trp Phe Leu Asn 
65                  70                  75                  80  


Leu Ala Val Ala Asp Phe Leu Phe Asn Val Phe Leu Pro Ile His Ile 
                85                  90                  95      


Thr Tyr Ala Ala Met Asp Tyr His Trp Val Phe Gly Thr Ala Met Cys 
            100                 105                 110         


Lys Ile Ser Asn Phe Leu Leu Ile His Asn Met Phe Thr Ser Val Phe 
        115                 120                 125             


Leu Leu Thr Ile Ile Ser Ser Asp Arg Cys Ile Ser Val Leu Leu Pro 
    130                 135                 140                 


Val Trp Ser Gln Asn His Arg Ser Val Arg Leu Ala Tyr Met Ala Cys 
145                 150                 155                 160 


Met Val Ile Trp Val Leu Ala Phe Phe Leu Ser Ser Pro Ser Leu Val 
                165                 170                 175     


Phe Arg Asp Thr Ala Asn Leu His Gly Lys Ile Ser Cys Phe Asn Asn 
            180                 185                 190         


Phe Ser Leu Ser Thr Pro Gly Ser Ser Ser Trp Pro Thr His Ser Gln 
        195                 200                 205             


Met Asp Pro Val Gly Tyr Ser Arg His Met Val Val Thr Val Thr Arg 
    210                 215                 220                 


Phe Leu Cys Gly Phe Leu Val Pro Val Leu Ile Ile Thr Ala Cys Tyr 
225                 230                 235                 240 


Leu Thr Ile Val Cys Lys Leu Gln Arg Asn Arg Leu Ala Lys Thr Lys 
                245                 250                 255     


Lys Pro Phe Lys Ile Ile Val Thr Ile Ile Ile Thr Phe Phe Leu Cys 
            260                 265                 270         


Trp Cys Pro Tyr His Thr Leu Asn Leu Leu Glu Leu His His Thr Ala 
        275                 280                 285             


Met Pro Gly Ser Val Phe Ser Leu Gly Leu Pro Leu Ala Thr Ala Leu 
    290                 295                 300                 


Ala Ile Ala Asn Ser Cys Met Asn Pro Ile Leu Tyr Val Phe Met Gly 
305                 310                 315                 320 


Gln Asp Phe Lys Lys Phe Lys Val Ala Leu Phe Ser Arg Leu Val Asn 
                325                 330                 335     


Ala Leu Ser Glu Asp Thr Gly His Ser Ser Tyr Pro Ser His Arg Ser 
            340                 345                 350         


Phe Thr Lys Met Ser Ser Met Asn Glu Arg Thr Ser Met Asn Glu Arg 
        355                 360                 365             


Glu Thr Gly Met Leu 
    370             


<210>  1644
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  1644

Met Arg Met Glu Asp Glu Asp Tyr Asn Thr Ser Ile Ser Tyr Gly Asp 
1               5                   10                  15      


Glu Tyr Pro Asp Tyr Leu Asp Ser Ile Val Val Leu Glu Asp Leu Ser 
            20                  25                  30          


Pro Leu Glu Ala Arg Val Thr Arg Ile Phe Leu Val Val Val Tyr Ser 
        35                  40                  45              


Ile Val Cys Phe Leu Gly Ile Leu Gly Asn Gly Leu Val Ile Ile Ile 
    50                  55                  60                  


Ala Thr Phe Lys Met Lys Lys Thr Val Asn Met Val Trp Phe Leu Asn 
65                  70                  75                  80  


Leu Ala Val Ala Asp Phe Leu Phe Asn Val Phe Leu Pro Ile His Ile 
                85                  90                  95      


Thr Tyr Ala Ala Met Asp Tyr His Trp Val Phe Gly Thr Ala Met Cys 
            100                 105                 110         


Lys Ile Ser Asn Phe Leu Leu Ile His Asn Met Phe Thr Ser Val Phe 
        115                 120                 125             


Leu Leu Thr Ile Ile Ser Ser Asp Arg Cys Ile Ser Val Leu Leu Pro 
    130                 135                 140                 


Val Trp Ser Gln Asn His Arg Ser Val Arg Leu Ala Tyr Met Ala Cys 
145                 150                 155                 160 


Met Val Ile Trp Val Leu Ala Phe Phe Leu Ser Ser Pro Ser Leu Val 
                165                 170                 175     


Phe Arg Asp Thr Ala Asn Leu His Gly Lys Ile Ser Cys Phe Asn Asn 
            180                 185                 190         


Phe Ser Leu Ser Thr Pro Gly Ser Ser Ser Trp Pro Thr His Ser Gln 
        195                 200                 205             


Met Asp Pro Val Gly Tyr Ser Arg His Met Val Val Thr Val Thr Arg 
    210                 215                 220                 


Phe Leu Cys Gly Phe Leu Val Pro Val Leu Ile Ile Thr Ala Cys Tyr 
225                 230                 235                 240 


Leu Thr Ile Val Cys Lys Leu Gln Arg Asn Arg Leu Ala Lys Thr Lys 
                245                 250                 255     


Lys Pro Phe Lys Ile Ile Val Thr Ile Ile Ile Thr Phe Phe Leu Cys 
            260                 265                 270         


Trp Cys Pro Tyr His Thr Leu Asn Leu Leu Glu Leu His His Thr Ala 
        275                 280                 285             


Met Pro Gly Ser Val Phe Ser Leu Gly Leu Pro Leu Ala Thr Ala Leu 
    290                 295                 300                 


Ala Ile Ala Asn Ser Cys Met Asn Pro Ile Leu Tyr Val Phe Met Gly 
305                 310                 315                 320 


Gln Asp Phe Lys Lys Phe Lys Val Ala Leu Phe Ser Arg Leu Val Asn 
                325                 330                 335     


Ala Leu Ser Glu Asp Thr Gly His Ser Ser Tyr Pro Ser His Arg Ser 
            340                 345                 350         


Phe Thr Lys Met Ser Ser Met Asn Glu Arg Thr Ser Met Asn Glu Arg 
        355                 360                 365             


Glu Thr Gly Met Leu 
    370             


<210>  1645
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  1645

Met Arg Met Glu Asp Glu Asp Tyr Asn Thr Ser Ile Ser Tyr Gly Asp 
1               5                   10                  15      


Glu Tyr Pro Asp Tyr Leu Asp Ser Ile Val Val Leu Glu Asp Leu Ser 
            20                  25                  30          


Pro Leu Glu Ala Arg Val Thr Arg Ile Phe Leu Val Val Val Tyr Ser 
        35                  40                  45              


Ile Val Cys Phe Leu Gly Ile Leu Gly Asn Gly Leu Val Ile Ile Ile 
    50                  55                  60                  


Ala Thr Phe Lys Met Lys Lys Thr Val Asn Met Val Trp Phe Leu Asn 
65                  70                  75                  80  


Leu Ala Val Ala Asp Phe Leu Phe Asn Val Phe Leu Pro Ile His Ile 
                85                  90                  95      


Thr Tyr Ala Ala Met Asp Tyr His Trp Val Phe Gly Thr Ala Met Cys 
            100                 105                 110         


Lys Ile Ser Asn Phe Leu Leu Ile His Asn Met Phe Thr Ser Val Phe 
        115                 120                 125             


Leu Leu Thr Ile Ile Ser Ser Asp Arg Cys Ile Ser Val Leu Leu Pro 
    130                 135                 140                 


Val Trp Ser Gln Asn His Arg Ser Val Arg Leu Ala Tyr Met Ala Cys 
145                 150                 155                 160 


Met Val Ile Trp Val Leu Ala Phe Phe Leu Ser Ser Pro Ser Leu Val 
                165                 170                 175     


Phe Arg Asp Thr Ala Asn Leu His Gly Lys Ile Ser Cys Phe Asn Asn 
            180                 185                 190         


Phe Ser Leu Ser Thr Pro Gly Ser Ser Ser Trp Pro Thr His Ser Gln 
        195                 200                 205             


Met Asp Pro Val Gly Tyr Ser Arg His Met Val Val Thr Val Thr Arg 
    210                 215                 220                 


Phe Leu Cys Gly Phe Leu Val Pro Val Leu Ile Ile Thr Ala Cys Tyr 
225                 230                 235                 240 


Leu Thr Ile Val Cys Lys Leu Gln Arg Asn Arg Leu Ala Lys Thr Lys 
                245                 250                 255     


Lys Pro Phe Lys Ile Ile Val Thr Ile Ile Ile Thr Phe Phe Leu Cys 
            260                 265                 270         


Trp Cys Pro Tyr His Thr Leu Asn Leu Leu Glu Leu His His Thr Ala 
        275                 280                 285             


Met Pro Gly Ser Val Phe Ser Leu Gly Leu Pro Leu Ala Thr Ala Leu 
    290                 295                 300                 


Ala Ile Ala Asn Ser Cys Met Asn Pro Ile Leu Tyr Val Phe Met Gly 
305                 310                 315                 320 


Gln Asp Phe Lys Lys Phe Lys Val Ala Leu Phe Ser Arg Leu Val Asn 
                325                 330                 335     


Ala Leu Ser Glu Asp Thr Gly His Ser Ser Tyr Pro Ser His Arg Ser 
            340                 345                 350         


Phe Thr Lys Met Ser Ser Met Asn Glu Arg Thr Ser Met Asn Glu Arg 
        355                 360                 365             


Glu Thr Gly Met Leu 
    370             


<210>  1646
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  1646

Met Pro Gly Ala Gly Asp Gly Gly Lys Ala Pro Ala Arg Trp Leu Gly 
1               5                   10                  15      


Thr Gly Leu Leu Val Glu Glu Val Asp Asn Thr Val Thr Leu Ile Ile 
            20                  25                  30          


Leu Ala Val Val Gly Gly Val Ile Gly Leu Leu Ile Leu Ile Leu Leu 
        35                  40                  45              


Ile Lys Lys Leu Ile Ile Phe Ile Leu Lys Lys Thr Arg Glu Lys Lys 
    50                  55                  60                  


Lys Glu Cys Leu Val Ser Ser Ser Gly Asn Asp Asn Thr Glu Asn Gly 
65                  70                  75                  80  


Leu Pro Gly Ser Lys Ala Glu Glu Lys Pro Pro Ser Lys Val 
                85                  90                  


<210>  1647
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  1647

Met Asn Asn Ile Ser Ile Val Leu Arg Asp Leu Glu Phe Ser Asp Thr 
1               5                   10                  15      


Gly Lys Tyr Thr Cys His Val Lys Asn Pro Lys Glu Asn Asn Leu Gln 
            20                  25                  30          


His His Ala Thr Ile Phe Leu Gln Val Val Asp Arg Leu Glu Glu Val 
        35                  40                  45              


Asp Asn Thr Val Thr Leu Ile Ile Leu Ala Val Val Gly Gly Val Ile 
    50                  55                  60                  


Gly Leu Leu Ile Leu Ile Leu Leu Ile Lys Lys Leu Ile Ile Phe Ile 
65                  70                  75                  80  


Leu Lys Lys Thr Arg Glu Lys Lys Lys Glu Cys Leu Val Ser Ser Ser 
                85                  90                  95      


Gly Asn Asp Asn Thr Glu Asn Gly Leu Pro Gly Ser Lys Ala Glu Glu 
            100                 105                 110         


Lys Pro Pro Ser Lys Val 
        115             


<210>  1648
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  1648

Met Lys Pro His Leu Lys Gln Trp Arg Gln Arg Met Leu Phe Gly Ile 
1               5                   10                  15      


Phe Ala Trp Gly Leu Leu Phe Leu Leu Ile Phe Ile Tyr Phe Thr Asp 
            20                  25                  30          


Ser Asn Pro Ala Glu Pro Val Pro Ser Ser Leu Ser Phe Leu Glu Thr 
        35                  40                  45              


Arg Arg Leu Leu Pro Val Gln Gly Lys Gln Arg Ala Ile Met Gly Ala 
    50                  55                  60                  


Ala His Glu Pro Ser Pro Pro Gly Gly Leu Asp Ala Arg Gln Ala Leu 
65                  70                  75                  80  


Pro Arg Ala His Pro Ala Gly Ser Phe His Ala Gly Pro Gly Asp Leu 
                85                  90                  95      


Gln Lys Trp Ala Gln Ser Gln Asp Gly Phe Glu His Lys Glu Phe Phe 
            100                 105                 110         


Ser Ser Gln Val Gly Arg Lys Ser Gln Ser Ala Phe Tyr Pro Glu Asp 
        115                 120                 125             


Asp Asp Tyr Phe Phe Ala Ala Gly Gln Pro Gly Trp His Ser His Thr 
    130                 135                 140                 


Gln Gly Thr Leu Gly Phe Pro Ser Pro Gly Glu Pro Gly Pro Arg Glu 
145                 150                 155                 160 


Gly Ala Phe Pro Ala Ala Gln Val Gln Arg Arg Arg Val Lys Lys Arg 
                165                 170                 175     


His Arg Arg Gln Arg Arg Ser His Val Leu Glu Glu Gly Asp Asp Gly 
            180                 185                 190         


Asp Arg Leu Tyr Ser Ser Met Ser Arg Ala Phe Leu Tyr Arg Leu Trp 
        195                 200                 205             


Lys Gly Asn Val Ser Ser Lys Met Leu Asn Pro Arg Leu Gln Lys Ala 
    210                 215                 220                 


Met Lys Asp Tyr Leu Thr Ala Asn Lys His Gly Val Arg Phe Arg Gly 
225                 230                 235                 240 


Lys Arg Glu Ala Gly Leu Ser Arg Ala Gln Leu Leu Cys Gln Leu Arg 
                245                 250                 255     


Ser Arg Ala Arg Val Arg Thr Leu Asp Gly Thr Glu Ala Pro Phe Ser 
            260                 265                 270         


Ala Leu Gly Trp Arg Arg Leu Val Pro Ala Val Pro Leu Ser Gln Leu 
        275                 280                 285             


His Pro Arg Gly Leu Arg Ser Cys Ala Val Val Met Ser Ala Gly Ala 
    290                 295                 300                 


Ile Leu Asn Ser Ser Leu Gly Glu Glu Ile Asp Ser His Asp Ala Val 
305                 310                 315                 320 


Leu Arg Phe Asn Ser Ala Pro Thr Arg Gly Tyr Glu Lys Asp Val Gly 
                325                 330                 335     


Asn Lys Thr Thr Ile Arg Ile Ile Asn Ser Gln Ile Leu Thr Asn Pro 
            340                 345                 350         


Ser His His Phe Ile Asp Ser Ser Leu Tyr Lys Asp Val Ile Leu Val 
        355                 360                 365             


Ala Trp Asp Pro Ala Pro Tyr Ser Ala Asn Leu Asn Leu Trp Tyr Lys 
    370                 375                 380                 


Lys Pro Asp Tyr Asn Leu Phe Thr Pro Tyr Ile Gln His Arg Gln Arg 
385                 390                 395                 400 


Asn Pro Asn Gln Pro Phe Tyr Ile Leu His Pro Lys Phe Ile Trp Gln 
                405                 410                 415     


Leu Trp Asp Ile Ile Gln Glu Asn Thr Lys Glu Lys Ile Gln Pro Asn 
            420                 425                 430         


Pro Pro Ser Ser Gly Phe Ile Gly Ile Leu Ile Met Met Ser Met Cys 
        435                 440                 445             


Arg Glu Val His Val Tyr Glu Tyr Ile Pro Ser Val Arg Gln Thr Glu 
    450                 455                 460                 


Leu Cys His Tyr His Glu Leu Tyr Tyr Asp Ala Ala Cys Thr Leu Gly 
465                 470                 475                 480 


Ala Tyr His Pro Leu Leu Tyr Glu Lys Leu Leu Val Gln Arg Leu Asn 
                485                 490                 495     


Met Gly Thr Gln Gly Asp Leu His Arg Lys Gly Lys Val Val Leu Pro 
            500                 505                 510         


Gly Phe Gln Ala Val His Cys Pro Ala Pro Ser Pro Val Ile Pro His 
        515                 520                 525             


Ser 
    


<210>  1649
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  1649

Met Lys Pro His Leu Lys Gln Trp Arg Gln Arg Met Leu Phe Gly Ile 
1               5                   10                  15      


Phe Ala Trp Gly Leu Leu Phe Leu Leu Ile Phe Ile Tyr Phe Thr Asp 
            20                  25                  30          


Ser Asn Pro Ala Glu Pro Val Pro Ser Ser Leu Ser Phe Leu Glu Thr 
        35                  40                  45              


Arg Arg Leu Leu Pro Val Gln Gly Lys Gln Arg Ala Ile Met Gly Ala 
    50                  55                  60                  


Ala His Glu Pro Ser Pro Pro Gly Gly Leu Asp Ala Arg Gln Ala Leu 
65                  70                  75                  80  


Pro Arg Ala His Pro Ala Gly Ser Phe His Ala Gly Pro Gly Asp Leu 
                85                  90                  95      


Gln Lys Trp Ala Gln Ser Gln Asp Gly Phe Glu His Lys Glu Phe Phe 
            100                 105                 110         


Ser Ser Gln Val Gly Arg Lys Ser Gln Ser Ala Phe Tyr Pro Glu Asp 
        115                 120                 125             


Asp Asp Tyr Phe Phe Ala Ala Gly Gln Pro Gly Trp His Ser His Thr 
    130                 135                 140                 


Gln Gly Thr Leu Gly Phe Pro Ser Pro Gly Glu Pro Gly Pro Arg Glu 
145                 150                 155                 160 


Gly Ala Phe Pro Ala Ala Gln Val Gln Arg Arg Arg Val Lys Lys Arg 
                165                 170                 175     


His Arg Arg Gln Arg Arg Ser His Val Leu Glu Glu Gly Asp Asp Gly 
            180                 185                 190         


Asp Arg Leu Tyr Ser Ser Met Ser Arg Ala Phe Leu Tyr Arg Leu Trp 
        195                 200                 205             


Lys Gly Asn Val Ser Ser Lys Met Leu Asn Pro Arg Leu Gln Lys Ala 
    210                 215                 220                 


Met Lys Asp Tyr Leu Thr Ala Asn Lys His Gly Val Arg Phe Arg Gly 
225                 230                 235                 240 


Lys Arg Glu Ala Gly Leu Ser Arg Ala Gln Leu Leu Cys Gln Leu Arg 
                245                 250                 255     


Ser Arg Ala Arg Val Arg Thr Leu Asp Gly Thr Glu Ala Pro Phe Ser 
            260                 265                 270         


Ala Leu Gly Trp Arg Arg Leu Val Pro Ala Val Pro Leu Ser Gln Leu 
        275                 280                 285             


His Pro Arg Gly Leu Arg Ser Cys Ala Val Val Met Ser Ala Gly Ala 
    290                 295                 300                 


Ile Leu Asn Ser Ser Leu Gly Glu Glu Ile Asp Ser His Asp Ala Val 
305                 310                 315                 320 


Leu Arg Phe Asn Ser Ala Pro Thr Arg Gly Tyr Glu Lys Asp Val Gly 
                325                 330                 335     


Asn Lys Thr Thr Ile Arg Ile Ile Asn Ser Gln Ile Leu Thr Asn Pro 
            340                 345                 350         


Ser His His Phe Ile Asp Ser Ser Leu Tyr Lys Asp Val Ile Leu Val 
        355                 360                 365             


Ala Trp Asp Pro Ala Pro Tyr Ser Ala Asn Leu Asn Leu Trp Tyr Lys 
    370                 375                 380                 


Lys Pro Asp Tyr Asn Leu Phe Thr Pro Tyr Ile Gln His Arg Gln Arg 
385                 390                 395                 400 


Asn Pro Asn Gln Pro Phe Tyr Ile Leu His Pro Lys Phe Ile Trp Gln 
                405                 410                 415     


Leu Trp Asp Ile Ile Gln Glu Asn Thr Lys Glu Lys Ile Gln Pro Asn 
            420                 425                 430         


Pro Pro Ser Ser Gly Phe Ile Gly Ser Phe Val Lys Ile Gly His Ile 
        435                 440                 445             


Arg Ala Cys Ser Glu Pro Arg Ser Arg Asp Cys Thr Pro Ala Trp Thr 
    450                 455                 460                 


Thr Glu 
465     


<210>  1650
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  1650

Met Ala Pro Leu Leu Leu Gln Leu Ala Val Leu Gly Ala Ala Leu Ala 
1               5                   10                  15      


Ala Ala Ala Leu Val Leu Ile Ser Ile Val Ala Phe Thr Thr Ala Thr 
            20                  25                  30          


Lys Met Pro Ala Leu His Arg His Glu Glu Glu Lys Phe Phe Leu Asn 
        35                  40                  45              


Ala Lys Gly Gln Lys Glu Thr Leu Pro Ser Ile Trp Asp Ser Pro Thr 
    50                  55                  60                  


Lys Gln Leu Ser Val Val Val Pro Ser Tyr Asn Glu Glu Lys Arg Leu 
65                  70                  75                  80  


Pro Val Met Met Asp Glu Ala Leu Ser Tyr Leu Glu Lys Arg Gln Lys 
                85                  90                  95      


Tyr Gly Ser Asp Lys Val Arg Val Ile Thr Leu Val Lys Asn Arg Gly 
            100                 105                 110         


Lys Gly Gly Ala Ile Arg Met Gly Ile Phe Ser Ser Arg Gly Glu Lys 
        115                 120                 125             


Ile Leu Met Ala Asp Ala Asp Gly Ala Thr Lys Phe Pro Asp Val Glu 
    130                 135                 140                 


Lys Leu Glu Lys Gly Leu Asn Asp Leu Gln Pro Trp Pro Asn Gln Met 
145                 150                 155                 160 


Ala Ile Ala Cys Gly Ser Arg Ala His Leu Glu Lys Glu Ser Ile Ala 
                165                 170                 175     


Gln Arg Ser Tyr Phe Arg Thr Leu Leu Met Tyr Gly Phe His Phe Leu 
            180                 185                 190         


Val Trp Phe Leu Cys Val Lys Gly Ile Arg Asp Thr Gln Cys Gly Phe 
        195                 200                 205             


Lys Leu Phe Thr Arg Glu Ala Ala Ser Arg Thr Phe Ser Ser Leu His 
    210                 215                 220                 


Val Glu Arg Trp Ala Phe Asp Val Glu Leu Leu Tyr Ile Ala Gln Phe 
225                 230                 235                 240 


Phe Lys Ile Pro Ile Ala Glu Ile Ala Val Asn Trp Thr Glu Ile Glu 
                245                 250                 255     


Gly Ser Lys Leu Val Pro Phe Trp Ser Trp Leu Gln Met Gly Lys Asp 
            260                 265                 270         


Leu Leu Phe Ile Arg Leu Arg Tyr Leu Thr Gly Ala Trp Arg Leu Glu 
        275                 280                 285             


Gln Thr Arg Lys Met Asn 
    290                 


<210>  1651
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  1651

Met Lys His Ile Asn Leu Ser Phe Ala Ala Cys Gly Phe Leu Gly Ile 
1               5                   10                  15      


Tyr His Leu Gly Ala Ala Ser Ala Leu Cys Arg His Gly Lys Lys Leu 
            20                  25                  30          


Val Lys Asp Val Lys Ala Phe Ala Gly Ala Ser Ala Gly Ser Leu Val 
        35                  40                  45              


Ala Ser Val Leu Leu Thr Ala Pro Glu Lys Ile Glu Glu Cys Asn Gln 
    50                  55                  60                  


Phe Thr Tyr Lys Phe Ala Glu Glu Ile Arg Arg Gln Ser Phe Gly Ala 
65                  70                  75                  80  


Val Thr Pro Gly Tyr Asp Phe Met Ala Arg Leu Arg Ser Gly Met Glu 
                85                  90                  95      


Ser Ile Leu Pro Pro Ser Ala His Glu Leu Ala Gln Asn Arg Leu His 
            100                 105                 110         


Val Ser Ile Thr Asn Ala Lys Thr Arg Glu Asn His Leu Val Ser Thr 
        115                 120                 125             


Phe Ser Ser Arg Glu Asp Leu Ile Lys Val Leu Leu Ala Ser Ser Phe 
    130                 135                 140                 


Val Pro Ile Tyr Ala Gly Leu Lys Leu Val Glu Tyr Lys Gly Gln Lys 
145                 150                 155                 160 


Trp Val Asp Gly Gly Leu Thr Asn Ala Leu Pro Ile Leu Pro Val Gly 
                165                 170                 175     


Arg Thr Val Thr Ile Ser Pro Phe Ser Gly Arg Leu Asp Ile Ser Pro 
            180                 185                 190         


Gln Asp Lys Gly Gln Leu Asp Leu Tyr Val Asn Ile Ala Lys Gln Asp 
        195                 200                 205             


Ile Met Leu Ser Leu Ala Asn Leu Val Arg Leu Asn Gln Ala Leu Phe 
    210                 215                 220                 


Pro Pro Ser Lys Arg Lys Met Glu Ser Leu Tyr Gln Cys Gly Phe Asp 
225                 230                 235                 240 


Asp Thr Val Lys Phe Leu Leu Lys Glu Asn Trp Phe Glu 
                245                 250             


<210>  1652
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  1652

Met Val Leu Met Gln Asp Lys Gly Ser Ser Gln Gln Trp Pro Gly Leu 
1               5                   10                  15      


Gly Gly Glu Gly Gly Gly Thr Gly Pro Leu Ser Met Leu Arg Ala Ala 
            20                  25                  30          


Leu Leu Leu Ile Ser Leu Pro Trp Gly Ala Gln Gly Thr Ala Ser Thr 
        35                  40                  45              


Ser Leu Ser Thr Ala Gly Gly His Thr Val Pro Pro Thr Gly Gly Arg 
    50                  55                  60                  


Tyr Leu Ser Ile Gly Asp Gly Ser Val Met Glu Phe Glu Phe Pro Glu 
65                  70                  75                  80  


Asp Ser Glu Gly Ile Ile Val Ile Ser Ser Gln Tyr Pro Gly Gln Ala 
                85                  90                  95      


Asn Arg Thr Ala Pro Gly Pro Met Leu Arg Val Thr Ser Leu Asp Thr 
            100                 105                 110         


Glu Val Leu Thr Ile Lys Asn Leu Val Asp Ala His Glu Ala Pro Pro 
        115                 120                 125             


Thr Leu Ile Glu Glu Arg Arg Asp Phe Cys Ile Lys Val Ser Pro Ala 
    130                 135                 140                 


Glu Asp Thr Pro Ala Thr Leu Ser Ala Asp Leu Ala His Phe Ser Glu 
145                 150                 155                 160 


Asn Pro Ile Leu Tyr Leu Leu Leu Pro Leu Ile Phe Val Asn Lys Cys 
                165                 170                 175     


Ser Phe Gly Cys Lys Val Glu Leu Glu Val Leu Lys Gly Leu Met Gln 
            180                 185                 190         


Ser Pro Gln Pro Met Leu Leu Gly Leu Leu Gly Gln Phe Leu Val Met 
        195                 200                 205             


Pro Leu Tyr Ala Phe Leu Met Ala Lys Val Phe Met Leu Pro Lys Ala 
    210                 215                 220                 


Leu Ala Leu Gly Leu Ile Ile Thr Cys Ser Ser Pro Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Tyr Leu Phe Ser Leu Leu Leu Gly Gly Asp Val Thr Leu Ala Ile 
                245                 250                 255     


Ser Met Thr Phe Leu Ser Thr Val Ala Ala Thr Gly Phe Leu Pro Leu 
            260                 265                 270         


Ser Ser Ala Ile Tyr Ser Arg Leu Leu Ser Ile His Glu Thr Leu His 
        275                 280                 285             


Val Pro Ile Ser Lys Ile Leu Gly Thr Leu Leu Phe Ile Ala Ile Pro 
    290                 295                 300                 


Ile Ala Val Gly Val Leu Ile Lys Ser Lys Leu Pro Lys Phe Ser Gln 
305                 310                 315                 320 


Leu Leu Leu Gln Val Val Lys Pro Phe Ser Phe Val Leu Leu Leu Gly 
                325                 330                 335     


Gly Leu Phe Leu Ala Tyr Arg Met Gly Val Phe Ile Leu Ala Gly Ile 
            340                 345                 350         


Arg Leu Pro Ile Val Leu Val Gly Ile Thr Val Pro Leu Val Gly Leu 
        355                 360                 365             


Leu Val Gly Tyr Cys Leu Ala Thr Cys Leu Lys Leu Pro Val Ala Gln 
    370                 375                 380                 


Arg Arg Thr Val Ser Ile Glu Val Gly Val Gln Asn Ser Leu Leu Ala 
385                 390                 395                 400 


Leu Ala Met Leu Gln Leu Ser Leu Arg Arg Leu Gln Ala Asp Tyr Ala 
                405                 410                 415     


Ser Gln Ala Pro Phe Ile Val Ala Leu Ser Gly Thr Ser Glu Met Leu 
            420                 425                 430         


Ala Leu Val Ile Gly His Phe Ile Tyr Ser Ser Leu Phe Pro Val Pro 
        435                 440                 445             


<210>  1653
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  1653

Met Val Leu Met Gln Asp Lys Gly Ser Ser Gln Gln Trp Pro Gly Leu 
1               5                   10                  15      


Gly Gly Glu Gly Gly Gly Thr Gly Pro Leu Ser Met Leu Arg Ala Ala 
            20                  25                  30          


Leu Leu Leu Ile Ser Leu Pro Trp Gly Ala Gln Gly Thr Ala Ser Thr 
        35                  40                  45              


Ser Leu Ser Thr Ala Gly Gly His Thr Val Pro Pro Thr Gly Gly Arg 
    50                  55                  60                  


Tyr Leu Ser Ile Gly Asp Gly Ser Val Met Glu Phe Glu Phe Pro Glu 
65                  70                  75                  80  


Asp Ser Glu Gly Ile Ile Val Ile Ser Ser Gln Tyr Pro Gly Gln Ala 
                85                  90                  95      


Asn Arg Thr Ala Pro Gly Pro Met Leu Arg Val Thr Ser Leu Asp Thr 
            100                 105                 110         


Glu Val Leu Thr Ile Lys Asn Val Ser Ala Ile Thr Trp Gly Gly Gly 
        115                 120                 125             


Gly Gly Phe Val Val Ser Ile His Ser Gly Leu Ala Gly Leu Ala Pro 
    130                 135                 140                 


Leu His Ile Gln Leu Val Asp Ala His Glu Ala Pro Pro Thr Leu Ile 
145                 150                 155                 160 


Glu Glu Arg Arg Asp Phe Cys Ile Lys Val Ser Pro Ala Glu Asp Thr 
                165                 170                 175     


Pro Ala Thr Leu Ser Ala Asp Leu Ala His Phe Ser Glu Asn Pro Ile 
            180                 185                 190         


Leu Tyr Leu Leu Leu Pro Leu Ile Phe Val Asn Lys Cys Ser Phe Gly 
        195                 200                 205             


Cys Lys Val Glu Leu Glu Val Leu Lys Gly Leu Met Gln Ser Pro Gln 
    210                 215                 220                 


Pro Met Leu Leu Gly Leu Leu Gly Gln Phe Leu Val Met Pro Leu Tyr 
225                 230                 235                 240 


Ala Phe Leu Met Ala Lys Val Phe Met Leu Pro Lys Ala Leu Ala Leu 
                245                 250                 255     


Gly Leu Ile Ile Thr Cys Ser Ser Pro Gly Gly Gly Gly Ser Tyr Leu 
            260                 265                 270         


Phe Ser Leu Leu Leu Gly Gly Asp Val Thr Leu Ala Ile Ser Met Thr 
        275                 280                 285             


Phe Leu Ser Thr Val Ala Ala Thr Gly Phe Leu Pro Leu Ser Ser Ala 
    290                 295                 300                 


Ile Tyr Ser Arg Leu Leu Ser Ile His Glu Thr Leu His Val Pro Ile 
305                 310                 315                 320 


Ser Lys Ile Leu Gly Thr Leu Leu Phe Ile Ala Ile Pro Ile Ala Val 
                325                 330                 335     


Gly Val Leu Ile Lys Ser Lys Leu Pro Lys Phe Ser Gln Leu Leu Leu 
            340                 345                 350         


Gln Val Val Lys Pro Phe Ser Phe Val Leu Leu Leu Gly Gly Leu Phe 
        355                 360                 365             


Leu Ala Tyr Arg Met Gly Val Phe Ile Leu Ala Gly Ile Arg Leu Pro 
    370                 375                 380                 


Ile Val Leu Val Gly Ile Thr Val Pro Leu Val Gly Leu Leu Val Gly 
385                 390                 395                 400 


Tyr Cys Leu Ala Thr Cys Leu Lys Leu Pro Val Ala Gln Arg Arg Thr 
                405                 410                 415     


Val Ser Ile Glu Val Gly Val Gln Asn Ser Leu Leu Ala Leu Ala Met 
            420                 425                 430         


Leu Gln Leu Ser Leu Arg Arg Leu Gln Ala Asp Tyr Ala Ser Gln Ala 
        435                 440                 445             


Pro Phe Ile Val Ala Leu Ser Gly Thr Ser Glu Met Leu Ala Leu Val 
    450                 455                 460                 


Ile Gly His Phe Ile Tyr Ser Ser Leu Phe Pro Val Pro 
465                 470                 475         


<210>  1654
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  1654

Met Gly Arg Val Phe Leu Thr Gly Glu Lys Ala Asn Ser Ile Leu Lys 
1               5                   10                  15      


Arg Tyr Pro Arg Ala Asn Gly Phe Phe Glu Glu Ile Arg Gln Gly Asn 
            20                  25                  30          


Ile Glu Arg Glu Cys Lys Glu Glu Phe Cys Thr Phe Glu Glu Ala Arg 
        35                  40                  45              


Glu Ala Phe Glu Asn Asn Glu Lys Thr Lys Glu Phe Trp Ser Thr Tyr 
    50                  55                  60                  


Thr Lys Ala Gln Gln Gly Glu Ser Asn Arg Gly Ser Asp Trp Phe Gln 
65                  70                  75                  80  


Phe Tyr Leu Thr Phe Pro Leu Ile Phe Gly Leu Phe Ile Ile Leu Leu 
                85                  90                  95      


Val Ile Phe Leu Ile Trp Arg Cys Phe Leu Arg Asn Lys Thr Arg Arg 
            100                 105                 110         


Gln Thr Val Thr Glu Gly His Ile Pro Phe Pro Gln His Leu Asn Ile 
        115                 120                 125             


Ile Thr Pro Pro Pro Pro Pro Asp Glu Val Phe Asp Ser Ser Gly Leu 
    130                 135                 140                 


Ser Pro Gly Phe Leu Gly Tyr Val Val Gly Arg Ser Asp Ser Val Ser 
145                 150                 155                 160 


Thr Arg Leu Ser Asn Cys Asp Pro Pro Pro Thr Tyr Glu Glu Ala Thr 
                165                 170                 175     


Gly Gln Val Asn Leu Gln Arg Ser Glu Thr Glu Pro His Leu Asp Pro 
            180                 185                 190         


Pro Pro Glu Tyr Glu Asp Ile Val Asn Ser Asn Ser Ala Ser Ala Ile 
        195                 200                 205             


Pro Met Val Pro Val Val Thr Thr Ile Lys 
    210                 215             


<210>  1655
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  1655

Met Ser Arg Leu Ser Arg Ser Leu Leu Trp Ala Ala Thr Cys Leu Gly 
1               5                   10                  15      


Val Leu Cys Val Leu Ser Ala Asp Lys Asn Thr Thr Gln His Pro Asn 
            20                  25                  30          


Val Thr Thr Leu Ala Pro Ile Ser Asn Val Thr Ser Ala Pro Val Thr 
        35                  40                  45              


Ser Leu Pro Leu Val Thr Thr Pro Ala Pro Glu Thr Cys Glu Gly Arg 
    50                  55                  60                  


Asn Ser Cys Val Ser Cys Phe Asn Val Ser Val Val Asn Thr Thr Cys 
65                  70                  75                  80  


Phe Trp Ile Glu Cys Lys Asp Glu Ser Tyr Cys Ser His Asn Ser Thr 
                85                  90                  95      


Val Ser Asp Cys Gln Val Gly Asn Thr Thr Asp Phe Cys Ser Ala Lys 
            100                 105                 110         


Pro Thr Val Gln Pro Ser Pro Ser Thr Thr Ser Lys Thr Val Thr Thr 
        115                 120                 125             


Ser Gly Thr Thr Asn Asn Thr Val Thr Pro Thr Ser Gln Pro Val Arg 
    130                 135                 140                 


Lys Ser Thr Phe Asp Ala Ala Ser Phe Ile Gly Gly Ile Val Leu Val 
145                 150                 155                 160 


Leu Gly Val Gln Ala Val Ile Phe Phe Leu Tyr Lys Phe Cys Lys Ser 
                165                 170                 175     


Lys Glu Arg Asn Tyr His Thr Leu 
            180                 


<210>  1656
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  1656

Met Ser Arg Leu Ser Arg Ser Leu Leu Trp Ala Ala Thr Cys Leu Gly 
1               5                   10                  15      


Val Leu Cys Val Leu Ser Ala Asp Lys Asn Thr Thr Gln His Pro Asn 
            20                  25                  30          


Val Thr Thr Leu Ala Pro Ile Ser Asn Val Thr Ser Ala Pro Val Thr 
        35                  40                  45              


Ser Leu Pro Leu Val Thr Thr Pro Ala Pro Glu Thr Cys Glu Gly Arg 
    50                  55                  60                  


Asn Ser Cys Val Ser Cys Phe Asn Val Ser Val Val Asn Thr Thr Cys 
65                  70                  75                  80  


Phe Trp Ile Glu Cys Lys Asp Glu Ser Tyr Cys Ser His Asn Ser Thr 
                85                  90                  95      


Val Ser Asp Cys Gln Val Gly Asn Thr Thr Asp Phe Cys Ser Val Ser 
            100                 105                 110         


Thr Ala Thr Pro Val Pro Thr Ala Asn Ser Thr Gly Thr Thr Asn Asn 
        115                 120                 125             


Thr Val Thr Pro Thr Ser Gln Pro Val Arg Lys Ser Thr Phe Asp Ala 
    130                 135                 140                 


Ala Ser Phe Ile Gly Gly Ile Val Leu Val Leu Gly Val Gln Ala Val 
145                 150                 155                 160 


Ile Phe Phe Leu Tyr Lys Phe Cys Lys Ser Lys Glu Arg Asn Tyr His 
                165                 170                 175     


Thr Leu 
        


<210>  1657
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  1657

Met Ser Arg Leu Ser Arg Ser Leu Leu Trp Ala Ala Thr Cys Leu Gly 
1               5                   10                  15      


Val Leu Cys Val Leu Ser Ala Asp Lys Asn Thr Thr Gln His Pro Asn 
            20                  25                  30          


Val Thr Thr Leu Ala Pro Ile Ser Asn Val Thr Ser Ala Pro Val Thr 
        35                  40                  45              


Ser Leu Pro Leu Val Thr Thr Pro Ala Pro Glu Thr Cys Glu Gly Arg 
    50                  55                  60                  


Asn Ser Cys Val Ser Cys Phe Asn Val Ser Val Val Asn Thr Thr Cys 
65                  70                  75                  80  


Phe Trp Ile Glu Cys Lys Asp Glu Ser Tyr Cys Ser His Asn Ser Thr 
                85                  90                  95      


Val Ser Asp Cys Gln Val Gly Asn Thr Thr Asp Phe Cys Ser Val Ser 
            100                 105                 110         


Thr Ala Thr Pro Val Pro Thr Ala Asn Ser Thr Ala Lys Pro Thr Val 
        115                 120                 125             


Gln Pro Ser Pro Ser Thr Thr Ser Lys Thr Val Thr Thr Ser Gly Thr 
    130                 135                 140                 


Thr Asn Asn Thr Val Thr Pro Thr Ser Gln Pro Val Arg Lys Ser Thr 
145                 150                 155                 160 


Phe Asp Ala Ala Ser Phe Ile Gly Gly Ile Val Leu Val Leu Glu Ile 
                165                 170                 175     


Arg Cys His Thr Arg Asn Tyr Ile Pro Asp Leu Lys Lys 
            180                 185                 


<210>  1658
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  1658

Met Ser Arg Leu Ser Arg Ser Leu Leu Trp Ala Ala Thr Cys Leu Gly 
1               5                   10                  15      


Val Leu Cys Val Leu Ser Ala Asp Lys Asn Thr Thr Gln His Pro Asn 
            20                  25                  30          


Val Thr Thr Leu Ala Pro Ile Ser Asn Val Thr Ser Ala Pro Val Thr 
        35                  40                  45              


Ser Leu Pro Leu Val Thr Thr Pro Ala Pro Glu Thr Cys Glu Gly Arg 
    50                  55                  60                  


Asn Ser Cys Val Ser Cys Phe Asn Val Ser Val Val Asn Thr Thr Cys 
65                  70                  75                  80  


Phe Trp Ile Glu Cys Lys Asp Glu Ser Tyr Cys Ser His Asn Ser Thr 
                85                  90                  95      


Val Ser Asp Cys Gln Val Gly Asn Thr Thr Asp Phe Cys Ser Val Ser 
            100                 105                 110         


Thr Ala Thr Pro Val Pro Thr Ala Asn Ser Thr Ala Lys Pro Thr Val 
        115                 120                 125             


Gln Pro Ser Pro Ser Thr Thr Ser Lys Thr Val Thr Thr Ser Glu Ile 
    130                 135                 140                 


Arg Cys His Thr Arg Asn Tyr Ile Pro Asp Leu Lys Lys 
145                 150                 155         


<210>  1659
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  1659

Met Trp Thr Phe Val Thr Gln Leu Leu Val Thr Leu Val Leu Leu Ser 
1               5                   10                  15      


Phe Phe Leu Val Ser Cys Gln Asn Val Met His Ile Val Arg Gly Ser 
            20                  25                  30          


Leu Cys Phe Val Leu Lys His Ile His Gln Glu Leu Asp Lys Glu Leu 
        35                  40                  45              


Gly Glu Ser Glu Gly Leu Ser Asp Asp Glu Glu Thr Ile Ser Thr Arg 
    50                  55                  60                  


Val Val Arg Arg Arg Val Phe Leu Lys Gly Asn Glu Phe Gln Asn Ile 
65                  70                  75                  80  


Pro Gly Glu Gln Val Thr Glu Glu Gln Phe Thr Asp Glu Gln Gly Asn 
                85                  90                  95      


Ile Val Thr Lys Lys Ile Ile Arg Lys Val Val Arg Gln Ile Asp Leu 
            100                 105                 110         


Ser Ser Ala Asp Ala Ala Gln Glu His Glu Glu Val Thr Val Glu Gly 
        115                 120                 125             


Pro Leu Glu Asp Pro Ser Glu Leu Glu Val Asp Ile Asp Tyr Phe Met 
    130                 135                 140                 


Lys His Ser Lys Asp His Thr Ser Thr Pro Asn Pro 
145                 150                 155     


<210>  1660
<211>  1897
<212>  PRT
<213>  Homo sapiens

<400>  1660

Met Ala Gln Ala Ala Lys Gln Leu Lys Lys Ile Lys Asp Ile Glu Ala 
1               5                   10                  15      


Gln Ala Leu Gln Glu Gln Lys Glu Lys Glu Glu Ser Asn Arg Lys Arg 
            20                  25                  30          


Arg Asn Arg Ser Arg Asp Arg Lys Lys Lys Ala Asp Ala Ala Thr Ser 
        35                  40                  45              


Phe Leu Arg Ala Ala Arg Ser Gly Asn Leu Asp Lys Ala Leu Asp His 
    50                  55                  60                  


Leu Arg Asn Gly Val Asp Ile Asn Thr Cys Asn Gln Asn Gly Leu Asn 
65                  70                  75                  80  


Gly Leu His Leu Ala Ser Lys Glu Gly His Val Lys Met Val Val Glu 
                85                  90                  95      


Leu Leu His Lys Glu Ile Ile Leu Glu Thr Thr Thr Lys Lys Gly Asn 
            100                 105                 110         


Thr Ala Leu His Ile Ala Ala Leu Ala Gly Gln Asp Glu Val Val Arg 
        115                 120                 125             


Glu Leu Val Asn Tyr Gly Ala Asn Val Asn Ala Gln Ser Gln Lys Gly 
    130                 135                 140                 


Phe Thr Pro Leu Tyr Met Ala Ala Gln Glu Asn His Leu Glu Val Val 
145                 150                 155                 160 


Lys Phe Leu Leu Glu Asn Gly Ala Asn Gln Asn Val Ala Thr Glu Asp 
                165                 170                 175     


Gly Phe Thr Pro Leu Ala Val Ala Leu Gln Gln Gly His Glu Asn Val 
            180                 185                 190         


Val Ala His Leu Ile Asn Tyr Gly Thr Lys Gly Lys Val Arg Leu Pro 
        195                 200                 205             


Ala Leu His Ile Ala Ala Arg Asn Asp Asp Thr Arg Thr Ala Ala Val 
    210                 215                 220                 


Leu Leu Gln Asn Asp Pro Asn Pro Asp Val Leu Ser Lys Thr Gly Phe 
225                 230                 235                 240 


Thr Pro Leu His Ile Ala Ala His Tyr Glu Asn Leu Asn Val Ala Gln 
                245                 250                 255     


Leu Leu Leu Asn Arg Gly Ala Ser Val Asn Phe Thr Pro Gln Asn Gly 
            260                 265                 270         


Ile Thr Pro Leu His Ile Ala Ser Arg Arg Gly Asn Val Ile Met Val 
        275                 280                 285             


Arg Leu Leu Leu Asp Arg Gly Ala Gln Ile Glu Thr Lys Thr Lys Asp 
    290                 295                 300                 


Glu Leu Thr Pro Leu His Cys Ala Ala Arg Asn Gly His Val Arg Ile 
305                 310                 315                 320 


Ser Glu Ile Leu Leu Asp His Gly Ala Pro Ile Gln Ala Lys Thr Lys 
                325                 330                 335     


Asn Gly Leu Ser Pro Ile His Met Ala Ala Gln Gly Asp His Leu Asp 
            340                 345                 350         


Cys Val Arg Leu Leu Leu Gln Tyr Asp Ala Glu Ile Asp Asp Ile Thr 
        355                 360                 365             


Leu Asp His Leu Thr Pro Leu His Val Ala Ala His Cys Gly His His 
    370                 375                 380                 


Arg Val Ala Lys Val Leu Leu Asp Lys Gly Ala Lys Pro Asn Ser Arg 
385                 390                 395                 400 


Ala Leu Asn Gly Phe Thr Pro Leu His Ile Ala Cys Lys Lys Asn His 
                405                 410                 415     


Val Arg Val Met Glu Leu Leu Leu Lys Thr Gly Ala Ser Ile Asp Ala 
            420                 425                 430         


Val Thr Glu Ser Gly Leu Thr Pro Leu His Val Ala Ser Phe Met Gly 
        435                 440                 445             


His Leu Pro Ile Val Lys Asn Leu Leu Gln Arg Gly Ala Ser Pro Asn 
    450                 455                 460                 


Val Ser Asn Val Lys Val Glu Thr Pro Leu His Met Ala Ala Arg Ala 
465                 470                 475                 480 


Gly His Thr Glu Val Ala Lys Tyr Leu Leu Gln Asn Lys Ala Lys Val 
                485                 490                 495     


Asn Ala Lys Ala Lys Asp Asp Gln Thr Pro Leu His Cys Ala Ala Arg 
            500                 505                 510         


Ile Gly His Thr Asn Met Val Lys Leu Leu Leu Glu Asn Asn Ala Asn 
        515                 520                 525             


Pro Asn Leu Ala Thr Thr Ala Gly His Thr Pro Leu His Ile Ala Ala 
    530                 535                 540                 


Arg Glu Gly His Val Glu Thr Val Leu Ala Leu Leu Glu Lys Glu Ala 
545                 550                 555                 560 


Ser Gln Ala Cys Met Thr Lys Lys Gly Phe Thr Pro Leu His Val Ala 
                565                 570                 575     


Ala Lys Tyr Gly Lys Val Arg Val Ala Glu Leu Leu Leu Glu Arg Asp 
            580                 585                 590         


Ala His Pro Asn Ala Ala Gly Lys Asn Gly Leu Thr Pro Leu His Val 
        595                 600                 605             


Ala Val His His Asn Asn Leu Asp Ile Val Lys Leu Leu Leu Pro Arg 
    610                 615                 620                 


Gly Gly Ser Pro His Ser Pro Ala Trp Asn Gly Tyr Thr Pro Leu His 
625                 630                 635                 640 


Ile Ala Ala Lys Gln Asn Gln Val Glu Val Ala Arg Ser Leu Leu Gln 
                645                 650                 655     


Tyr Gly Gly Ser Ala Asn Ala Glu Ser Val Gln Gly Val Thr Pro Leu 
            660                 665                 670         


His Leu Ala Ala Gln Glu Gly His Ala Glu Met Val Ala Leu Leu Leu 
        675                 680                 685             


Ser Lys Gln Ala Asn Gly Asn Leu Gly Asn Lys Ser Gly Leu Thr Pro 
    690                 695                 700                 


Leu His Leu Val Ala Gln Glu Gly His Val Pro Val Ala Asp Val Leu 
705                 710                 715                 720 


Ile Lys His Gly Val Met Val Asp Ala Thr Thr Arg Met Gly Tyr Thr 
                725                 730                 735     


Pro Leu His Val Ala Ser His Tyr Gly Asn Ile Lys Leu Val Lys Phe 
            740                 745                 750         


Leu Leu Gln His Gln Ala Asp Val Asn Ala Lys Thr Lys Leu Gly Tyr 
        755                 760                 765             


Ser Pro Leu His Gln Ala Ala Gln Gln Gly His Thr Asp Ile Val Thr 
    770                 775                 780                 


Leu Leu Leu Lys Asn Gly Ala Ser Pro Asn Glu Val Ser Ser Asp Gly 
785                 790                 795                 800 


Thr Thr Pro Leu Ala Ile Ala Lys Arg Leu Gly Tyr Ile Ser Val Thr 
                805                 810                 815     


Asp Val Leu Lys Val Val Thr Asp Glu Thr Ser Phe Val Leu Val Ser 
            820                 825                 830         


Asp Lys His Arg Met Ser Phe Pro Glu Thr Val Asp Glu Ile Leu Asp 
        835                 840                 845             


Val Ser Glu Asp Glu Gly Thr Ala His Ile Thr Ile Met Gly Glu Glu 
    850                 855                 860                 


Leu Ile Ser Phe Lys Ala Glu Arg Arg Asp Ser Arg Asp Val Asp Glu 
865                 870                 875                 880 


Glu Lys Glu Leu Leu Asp Phe Val Pro Lys Leu Asp Gln Val Val Glu 
                885                 890                 895     


Ser Pro Ala Ile Pro Arg Ile Pro Cys Ala Met Pro Glu Thr Val Val 
            900                 905                 910         


Ile Arg Ser Glu Glu Gln Glu Gln Ala Ser Lys Glu Tyr Asp Glu Asp 
        915                 920                 925             


Ser Leu Ile Pro Ser Ser Pro Ala Thr Glu Thr Ser Asp Asn Ile Ser 
    930                 935                 940                 


Pro Val Ala Ser Pro Val His Thr Gly Phe Leu Val Ser Phe Met Val 
945                 950                 955                 960 


Asp Ala Arg Gly Gly Ser Met Arg Gly Ser Arg His Asn Gly Leu Arg 
                965                 970                 975     


Val Val Ile Pro Pro Arg Thr Cys Ala Ala Pro Thr Arg Ile Thr Cys 
            980                 985                 990         


Arg Leu Val Lys Pro Gln Lys Leu  Ser Thr Pro Pro Pro  Leu Ala Glu 
        995                 1000                 1005             


Glu Glu  Gly Leu Ala Ser Arg  Ile Ile Ala Leu Gly  Pro Thr Gly 
    1010                 1015                 1020             


Ala Gln  Phe Leu Ser Pro Val  Ile Val Glu Ile Pro  His Phe Ala 
    1025                 1030                 1035             


Ser His  Gly Arg Gly Asp Arg  Glu Leu Val Val Leu  Arg Ser Glu 
    1040                 1045                 1050             


Asn Gly  Ser Val Trp Lys Glu  His Arg Ser Arg Tyr  Gly Glu Ser 
    1055                 1060                 1065             


Tyr Leu  Asp Gln Ile Leu Asn  Gly Met Asp Glu Glu  Leu Gly Ser 
    1070                 1075                 1080             


Leu Glu  Glu Leu Glu Lys Lys  Arg Val Cys Arg Ile  Ile Thr Thr 
    1085                 1090                 1095             


Asp Phe  Pro Leu Tyr Phe Val  Ile Met Ser Arg Leu  Cys Gln Asp 
    1100                 1105                 1110             


Tyr Asp  Thr Ile Gly Pro Glu  Gly Gly Ser Leu Lys  Ser Lys Leu 
    1115                 1120                 1125             


Val Pro  Leu Val Gln Ala Thr  Phe Pro Glu Asn Ala  Val Thr Lys 
    1130                 1135                 1140             


Arg Val  Lys Leu Ala Leu Gln  Ala Gln Pro Val Pro  Asp Glu Leu 
    1145                 1150                 1155             


Val Thr  Lys Leu Leu Gly Asn  Gln Ala Thr Phe Ser  Pro Ile Val 
    1160                 1165                 1170             


Thr Val  Glu Pro Arg Arg Arg  Lys Phe His Arg Pro  Ile Gly Leu 
    1175                 1180                 1185             


Arg Ile  Pro Leu Pro Pro Ser  Trp Thr Asp Asn Pro  Arg Asp Ser 
    1190                 1195                 1200             


Gly Glu  Gly Asp Thr Thr Ser  Leu Arg Leu Leu Cys  Ser Val Ile 
    1205                 1210                 1215             


Gly Gly  Thr Asp Gln Ala Gln  Trp Glu Asp Ile Thr  Gly Thr Thr 
    1220                 1225                 1230             


Lys Leu  Val Tyr Ala Asn Glu  Cys Ala Asn Phe Thr  Thr Asn Val 
    1235                 1240                 1245             


Ser Ala  Arg Phe Trp Leu Ser  Asp Cys Pro Arg Thr  Ala Glu Ala 
    1250                 1255                 1260             


Val Asn  Phe Ala Thr Leu Leu  Tyr Lys Glu Leu Thr  Ala Val Pro 
    1265                 1270                 1275             


Tyr Met  Ala Lys Phe Val Ile  Phe Ala Lys Met Asn  Asp Pro Arg 
    1280                 1285                 1290             


Glu Gly  Arg Leu Arg Cys Tyr  Cys Met Thr Asp Asp  Lys Val Asp 
    1295                 1300                 1305             


Lys Thr  Leu Glu Gln His Glu  Asn Phe Val Glu Val  Ala Arg Ser 
    1310                 1315                 1320             


Arg Asp  Ile Glu Val Leu Glu  Gly Met Ser Leu Phe  Ala Glu Leu 
    1325                 1330                 1335             


Ser Gly  Asn Leu Val Pro Val  Lys Lys Ala Ala Gln  Gln Arg Ser 
    1340                 1345                 1350             


Phe His  Phe Gln Ser Phe Arg  Glu Asn Arg Leu Ala  Met Pro Val 
    1355                 1360                 1365             


Lys Val  Arg Asp Ser Ser Arg  Glu Pro Gly Gly Ser  Leu Ser Phe 
    1370                 1375                 1380             


Leu Arg  Lys Ala Met Lys Tyr  Glu Asp Thr Gln His  Ile Leu Cys 
    1385                 1390                 1395             


His Leu  Asn Ile Thr Met Pro  Pro Cys Ala Lys Gly  Ser Gly Ala 
    1400                 1405                 1410             


Glu Asp  Arg Arg Arg Thr Pro  Thr Pro Leu Ala Leu  Arg Tyr Ser 
    1415                 1420                 1425             


Ile Leu  Ser Glu Ser Thr Pro  Gly Ser Leu Ser Gly  Thr Glu Gln 
    1430                 1435                 1440             


Ala Glu  Met Lys Met Ala Val  Ile Ser Glu His Leu  Gly Leu Ser 
    1445                 1450                 1455             


Trp Ala  Glu Leu Ala Arg Glu  Leu Gln Phe Ser Val  Glu Asp Ile 
    1460                 1465                 1470             


Asn Arg  Ile Arg Val Glu Asn  Pro Asn Ser Leu Leu  Glu Gln Ser 
    1475                 1480                 1485             


Val Ala  Leu Leu Asn Leu Trp  Val Ile Arg Glu Gly  Gln Asn Ala 
    1490                 1495                 1500             


Asn Met  Glu Asn Leu Tyr Thr  Ala Leu Gln Ser Ile  Asp Arg Gly 
    1505                 1510                 1515             


Glu Ile  Val Asn Met Leu Glu  Gly Ser Gly Arg Gln  Ser Arg Asn 
    1520                 1525                 1530             


Leu Lys  Pro Asp Arg Arg His  Thr Asp Arg Asp Tyr  Ser Leu Ser 
    1535                 1540                 1545             


Pro Ser  Gln Met Asn Gly Tyr  Ser Ser Leu Gln Asp  Glu Leu Leu 
    1550                 1555                 1560             


Ser Pro  Ala Ser Leu Gly Cys  Ala Leu Ser Ser Pro  Leu Arg Ala 
    1565                 1570                 1575             


Asp Gln  Tyr Trp Asn Glu Val  Ala Val Leu Asp Ala  Ile Pro Leu 
    1580                 1585                 1590             


Ala Ala  Thr Glu His Asp Thr  Met Leu Glu Met Ser  Asp Met Gln 
    1595                 1600                 1605             


Val Trp  Ser Ala Gly Leu Thr  Pro Ser Leu Val Thr  Ala Glu Asp 
    1610                 1615                 1620             


Ser Ser  Leu Glu Cys Ser Lys  Ala Glu Asp Ser Asp  Ala Thr Gly 
    1625                 1630                 1635             


His Glu  Trp Lys Leu Glu Gly  Ala Leu Ser Glu Glu  Pro Arg Gly 
    1640                 1645                 1650             


Pro Glu  Leu Gly Ser Leu Glu  Leu Val Glu Asp Asp  Thr Val Asp 
    1655                 1660                 1665             


Ser Asp  Ala Thr Asn Gly Leu  Ile Asp Leu Leu Glu  Gln Glu Glu 
    1670                 1675                 1680             


Gly Gln  Arg Ser Glu Glu Lys  Leu Pro Gly Ser Lys  Arg Gln Asp 
    1685                 1690                 1695             


Asp Ala  Thr Gly Ala Gly Gln  Asp Ser Glu Asn Glu  Val Ser Leu 
    1700                 1705                 1710             


Val Ser  Gly His Gln Arg Gly  Gln Ala Arg Ile Thr  His Ser Pro 
    1715                 1720                 1725             


Thr Val  Ser Gln Val Thr Glu  Arg Ser Gln Asp Arg  Leu Gln Asp 
    1730                 1735                 1740             


Trp Asp  Ala Asp Gly Ser Ile  Val Ser Tyr Leu Gln  Asp Ala Ala 
    1745                 1750                 1755             


Gln Gly  Ser Trp Gln Glu Glu  Val Thr Gln Gly Pro  His Ser Phe 
    1760                 1765                 1770             


Gln Gly  Thr Ser Thr Met Thr  Glu Gly Leu Glu Pro  Gly Gly Ser 
    1775                 1780                 1785             


Gln Glu  Tyr Glu Lys Val Leu  Val Ser Val Ser Glu  His Thr Trp 
    1790                 1795                 1800             


Thr Glu  Gln Pro Glu Ala Glu  Ser Ser Gln Ala Asp  Arg Asp Arg 
    1805                 1810                 1815             


Arg Gln  Gln Gly Gln Glu Glu  Gln Val Gln Glu Ala  Lys Asn Thr 
    1820                 1825                 1830             


Phe Thr  Gln Val Val Gln Gly  Asn Glu Phe Gln Asn  Ile Pro Gly 
    1835                 1840                 1845             


Glu Gln  Val Thr Glu Glu Gln  Phe Thr Asp Glu Gln  Gly Asn Ile 
    1850                 1855                 1860             


Val Thr  Lys Lys Ile Ile Arg  Lys Val Val Arg Gln  Ile Asp Leu 
    1865                 1870                 1875             


Ser Ser  Ala Asp Ala Ala Gln  Glu His Glu Glu Asp  His Thr Ser 
    1880                 1885                 1890             


Thr Pro  Asn Pro 
    1895         


<210>  1661
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  1661

Met Arg Arg Gln Leu Arg Ser Arg Arg Ala Pro Ser Phe Pro Tyr Ser 
1               5                   10                  15      


Tyr Arg Tyr Arg Leu Asp Asp Pro Asp Glu Ala Asn Gln Asn Tyr Leu 
            20                  25                  30          


Ala Asp Glu Glu Glu Glu Ala Glu Glu Glu Ala Arg Val Thr Val Val 
        35                  40                  45              


Pro Lys Ser Glu Glu Glu Glu Glu Glu Glu Glu Lys Glu Glu Glu Glu 
    50                  55                  60                  


Glu Glu Glu Lys Glu Glu Glu Glu Gly Gln Gly Gln Pro Thr Gly Asn 
65                  70                  75                  80  


Ala Trp Trp Gln Lys Leu Gln Ile Met Ser Glu Tyr Leu Trp Asp Pro 
                85                  90                  95      


Glu Arg Arg Met Phe Leu Ala Arg Thr Gly Gln Ser Trp Ser Leu Ile 
            100                 105                 110         


Leu Leu Ile Tyr Phe Phe Phe Tyr Ala Ser Leu Ala Ala Val Ile Thr 
        115                 120                 125             


Leu Cys Met Tyr Thr Leu Phe Leu Thr Ile Ser Pro Tyr Ile Pro Thr 
    130                 135                 140                 


Phe Thr Glu Arg Val Lys Pro Pro Gly Val Met Ile Arg Pro Phe Ala 
145                 150                 155                 160 


His Ser Leu Asn Phe Asn Phe Asn Val Ser Glu Pro Asp Thr Trp Gln 
                165                 170                 175     


His Tyr Val Ile Ser Leu Asn Gly Phe Leu Gln Gly Tyr Asn Asp Ser 
            180                 185                 190         


Leu Gln Glu Glu Met Asn Val Asp Cys Pro Pro Gly Gln Tyr Phe Ile 
        195                 200                 205             


Gln Asp Gly Asn Glu Asp Glu Asp Lys Lys Ala Cys Gln Phe Lys Arg 
    210                 215                 220                 


Ser Phe Leu Lys Asn Cys Ser Gly Leu Glu Asp Pro Thr Phe Gly Tyr 
225                 230                 235                 240 


Ser Thr Gly Gln Pro Cys Ile Leu Leu Lys Met Asn Arg Ile Val Gly 
                245                 250                 255     


Phe Arg Pro Glu Leu Gly Asp Pro Val Lys Val Ser Cys Lys Val Gln 
            260                 265                 270         


Arg Gly Asp Glu Asn Asp Ile Arg Ser Ile Ser Tyr Tyr Pro Glu Ser 
        275                 280                 285             


Ala Ser Phe Asp Leu Arg Tyr Tyr Pro Tyr Tyr Gly Lys Leu Thr His 
    290                 295                 300                 


Val Asn Tyr Thr Ser Pro Leu Val Ala Met His Phe Thr Asp Val Val 
305                 310                 315                 320 


Lys Asn Gln Ala Val Pro Val Gln Cys Gln Leu Lys Gly Lys Gly Val 
                325                 330                 335     


Ile Asn Asp Val Ile Asn Asp Arg Phe Val Gly Arg Val Ile Phe Thr 
            340                 345                 350         


Leu Asn Ile Glu Thr 
        355         


<210>  1662
<211>  528
<212>  PRT
<213>  Homo sapiens

<400>  1662

Met Ala Gly Ser Asp Thr Ala Pro Phe Leu Ser Gln Ala Asp Asp Pro 
1               5                   10                  15      


Asp Asp Gly Pro Val Pro Gly Thr Pro Gly Leu Pro Gly Ser Thr Gly 
            20                  25                  30          


Asn Pro Lys Ser Glu Glu Pro Glu Val Pro Asp Gln Glu Gly Leu Gln 
        35                  40                  45              


Arg Ile Thr Gly Leu Ser Pro Gly Arg Ser Ala Leu Ile Val Ala Val 
    50                  55                  60                  


Leu Cys Tyr Ile Asn Leu Leu Asn Tyr Met Asp Arg Phe Thr Val Ala 
65                  70                  75                  80  


Gly Val Leu Pro Asp Ile Glu Gln Phe Phe Asn Ile Gly Asp Ser Ser 
                85                  90                  95      


Ser Gly Leu Ile Gln Thr Val Phe Ile Ser Ser Tyr Met Val Leu Ala 
            100                 105                 110         


Pro Val Phe Gly Tyr Leu Gly Asp Arg Tyr Asn Arg Lys Tyr Leu Met 
        115                 120                 125             


Cys Gly Gly Ile Ala Phe Trp Ser Leu Val Thr Leu Gly Ser Ser Phe 
    130                 135                 140                 


Ile Pro Gly Glu His Phe Trp Leu Leu Leu Leu Thr Arg Gly Leu Val 
145                 150                 155                 160 


Gly Val Gly Glu Ala Ser Tyr Ser Thr Ile Ala Pro Thr Leu Ile Ala 
                165                 170                 175     


Asp Leu Phe Val Ala Asp Gln Arg Ser Arg Met Leu Ser Ile Phe Tyr 
            180                 185                 190         


Phe Ala Ile Pro Val Gly Ser Gly Leu Gly Tyr Ile Ala Gly Ser Lys 
        195                 200                 205             


Val Lys Asp Met Ala Gly Asp Trp His Trp Ala Leu Arg Val Thr Pro 
    210                 215                 220                 


Gly Leu Gly Val Val Ala Val Leu Leu Leu Phe Leu Val Val Arg Glu 
225                 230                 235                 240 


Pro Pro Arg Gly Ala Val Glu Arg His Ser Asp Leu Pro Pro Leu Asn 
                245                 250                 255     


Pro Thr Ser Trp Trp Ala Asp Leu Arg Ala Leu Ala Arg Asn Pro Ser 
            260                 265                 270         


Phe Val Leu Ser Ser Leu Gly Phe Thr Ala Val Ala Phe Val Thr Gly 
        275                 280                 285             


Ser Leu Ala Leu Trp Ala Pro Ala Phe Leu Leu Arg Ser Arg Val Val 
    290                 295                 300                 


Leu Gly Glu Thr Pro Pro Cys Leu Pro Gly Asp Ser Cys Ser Ser Ser 
305                 310                 315                 320 


Asp Ser Leu Ile Phe Gly Leu Ile Thr Cys Leu Thr Gly Val Leu Gly 
                325                 330                 335     


Val Gly Leu Gly Val Glu Ile Ser Arg Arg Leu Arg His Ser Asn Pro 
            340                 345                 350         


Arg Ala Asp Pro Leu Val Cys Ala Thr Gly Leu Leu Gly Ser Ala Pro 
        355                 360                 365             


Phe Leu Phe Leu Ser Leu Ala Cys Ala Arg Gly Ser Ile Val Ala Thr 
    370                 375                 380                 


Tyr Ile Phe Ile Phe Ile Gly Glu Thr Leu Leu Ser Met Asn Trp Ala 
385                 390                 395                 400 


Ile Val Ala Asp Ile Leu Leu Tyr Val Val Ile Pro Thr Arg Arg Ser 
                405                 410                 415     


Thr Ala Glu Ala Phe Gln Ile Val Leu Ser His Leu Leu Gly Asp Ala 
            420                 425                 430         


Gly Ser Pro Tyr Leu Ile Gly Leu Ile Ser Asp Arg Leu Arg Arg Asn 
        435                 440                 445             


Trp Pro Pro Ser Phe Leu Ser Glu Phe Arg Ala Leu Gln Phe Ser Leu 
    450                 455                 460                 


Met Leu Cys Ala Phe Val Gly Ala Leu Gly Gly Ala Ala Phe Leu Gly 
465                 470                 475                 480 


Thr Ala Ile Phe Ile Glu Ala Asp Arg Arg Arg Ala Gln Leu His Val 
                485                 490                 495     


Gln Gly Leu Leu His Glu Ala Gly Ser Thr Asp Asp Arg Ile Val Val 
            500                 505                 510         


Pro Gln Arg Gly Arg Ser Thr Arg Val Pro Val Ala Ser Val Leu Ile 
        515                 520                 525             


<210>  1663
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  1663

Met Ala Gly Ser Asp Thr Ala Pro Phe Leu Ser Gln Ala Asp Asp Pro 
1               5                   10                  15      


Asp Asp Gly Pro Val Pro Gly Thr Pro Gly Leu Pro Gly Ser Thr Gly 
            20                  25                  30          


Asn Pro Lys Ser Glu Glu Pro Glu Val Pro Asp Gln Glu Gly Leu Gln 
        35                  40                  45              


Arg Ile Thr Gly Leu Ser Pro Gly Arg Ser Ala Leu Ile Val Ala Val 
    50                  55                  60                  


Leu Cys Tyr Ile Asn Leu Leu Asn Tyr Met Asp Arg Phe Thr Val Ala 
65                  70                  75                  80  


Val Phe Ile Ser Ser Tyr Met Val Leu Ala Pro Val Phe Gly Tyr Leu 
                85                  90                  95      


Gly Asp Arg Tyr Asn Arg Lys Tyr Leu Met Cys Gly Gly Ile Ala Phe 
            100                 105                 110         


Trp Ser Leu Val Thr Leu Gly Ser Ser Phe Ile Pro Gly Glu His Phe 
        115                 120                 125             


Trp Leu Leu Leu Leu Thr Arg Gly Leu Val Gly Val Gly Glu Ala Ser 
    130                 135                 140                 


Tyr Ser Thr Ile Ala Pro Thr Leu Ile Ala Asp Leu Phe Val Ala Asp 
145                 150                 155                 160 


Gln Arg Ser Arg Met Leu Ser Ile Phe Tyr Phe Ala Ile Pro Val Gly 
                165                 170                 175     


Ser Gly Leu Gly Tyr Ile Ala Gly Ser Lys Val Lys Asp Met Ala Gly 
            180                 185                 190         


Asp Trp His Trp Ala Leu Arg Val Thr Pro Gly Leu Gly Val Val Ala 
        195                 200                 205             


Val Leu Leu Leu Phe Leu Val Val Arg Glu Pro Pro Arg Gly Ala Val 
    210                 215                 220                 


Glu Arg His Ser Asp Leu Pro Pro Leu Asn Pro Thr Ser Trp Trp Ala 
225                 230                 235                 240 


Asp Leu Arg Ala Leu Ala Arg Asn Leu Ile Phe Gly Leu Ile Thr Cys 
                245                 250                 255     


Leu Thr Gly Val Leu Gly Val Gly Leu Gly Val Glu Ile Ser Arg Arg 
            260                 265                 270         


Leu Arg His Ser Asn Pro Arg Ala Asp Pro Leu Val Cys Ala Thr Gly 
        275                 280                 285             


Leu Leu Gly Ser Ala Pro Phe Leu Phe Leu Ser Leu Ala Cys Ala Arg 
    290                 295                 300                 


Gly Ser Ile Val Ala Thr Tyr Ile Phe Ile Phe Ile Gly Glu Thr Leu 
305                 310                 315                 320 


Leu Ser Met Asn Trp Ala Ile Val Ala Asp Ile Leu Leu Tyr Val Val 
                325                 330                 335     


Ile Pro Thr Arg Arg Ser Thr Ala Glu Ala Phe Gln Ile Val Leu Ser 
            340                 345                 350         


His Leu Leu Gly Asp Ala Gly Ser Pro Tyr Leu Ile Gly Leu Ile Ser 
        355                 360                 365             


Asp Arg Leu Arg Arg Asn Trp Pro Pro Ser Phe Leu Ser Glu Phe Arg 
    370                 375                 380                 


Ala Leu Gln Phe Ser Leu Met Leu Cys Ala Phe Val Gly Ala Leu Gly 
385                 390                 395                 400 


Gly Ala Ala Phe Leu Gly Thr Ala Ile Phe Ile Glu Ala Asp Arg Arg 
                405                 410                 415     


Arg Ala Gln Leu His Val Gln Gly Leu Leu His Glu Ala Gly Ser Thr 
            420                 425                 430         


Asp Asp Arg Ile Val Val Pro Gln Arg Gly Arg Ser Thr Arg Val Pro 
        435                 440                 445             


Val Ala Ser Val Leu Ile 
    450                 


<210>  1664
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  1664

Met Asp Arg Phe Thr Val Ala Gly Val Leu Pro Asp Ile Glu Gln Phe 
1               5                   10                  15      


Phe Asn Ile Gly Asp Ser Ser Ser Gly Leu Ile Gln Thr Val Phe Ile 
            20                  25                  30          


Ser Ser Tyr Met Val Leu Ala Pro Val Phe Gly Tyr Leu Gly Asp Arg 
        35                  40                  45              


Tyr Asn Arg Lys Tyr Leu Met Cys Gly Gly Ile Ala Phe Trp Ser Leu 
    50                  55                  60                  


Val Thr Leu Gly Ser Ser Phe Ile Pro Gly Glu His Phe Trp Leu Leu 
65                  70                  75                  80  


Leu Leu Thr Arg Gly Leu Val Gly Val Gly Glu Ala Ser Tyr Ser Thr 
                85                  90                  95      


Ile Ala Pro Thr Leu Ile Ala Asp Leu Phe Val Ala Asp Gln Arg Ser 
            100                 105                 110         


Arg Met Leu Ser Ile Phe Tyr Phe Ala Ile Pro Val Gly Ser Gly Leu 
        115                 120                 125             


Gly Tyr Ile Ala Gly Ser Lys Val Lys Asp Met Ala Gly Asp Trp His 
    130                 135                 140                 


Trp Ala Leu Arg Val Thr Pro Gly Leu Gly Val Val Ala Val Leu Leu 
145                 150                 155                 160 


Leu Phe Leu Val Val Arg Glu Pro Pro Arg Gly Ala Val Glu Arg His 
                165                 170                 175     


Ser Asp Leu Pro Pro Leu Asn Pro Thr Ser Trp Trp Ala Asp Leu Arg 
            180                 185                 190         


Ala Leu Ala Arg Asn Pro Ser Phe Val Leu Ser Ser Leu Gly Phe Thr 
        195                 200                 205             


Ala Val Ala Phe Val Thr Gly Ser Leu Ala Leu Trp Ala Pro Ala Phe 
    210                 215                 220                 


Leu Leu Arg Ser Arg Val Val Leu Gly Glu Thr Pro Pro Cys Leu Pro 
225                 230                 235                 240 


Gly Asp Ser Cys Ser Ser Ser Asp Ser Leu Ile Phe Gly Leu Ile Thr 
                245                 250                 255     


Cys Leu Thr Gly Val Leu Gly Val Gly Leu Gly Val Glu Ile Ser Arg 
            260                 265                 270         


Arg Leu Arg His Ser Asn Pro Arg Ala Asp Pro Leu Val Cys Ala Thr 
        275                 280                 285             


Gly Leu Leu Gly Ser Ala Pro Phe Leu Phe Leu Ser Leu Ala Cys Ala 
    290                 295                 300                 


Arg Gly Ser Ile Val Ala Thr Tyr Ile Phe Ile Phe Ile Gly Glu Thr 
305                 310                 315                 320 


Leu Leu Ser Met Asn Trp Ala Ile Val Ala Asp Ile Leu Leu Tyr Val 
                325                 330                 335     


Val Ile Pro Thr Arg Arg Ser Thr Ala Glu Ala Phe Gln Ile Val Leu 
            340                 345                 350         


Ser His Leu Leu Gly Asp Ala Gly Ser Pro Tyr Leu Ile Gly Leu Ile 
        355                 360                 365             


Ser Asp Arg Leu Arg Arg Asn Trp Pro Pro Ser Phe Leu Ser Glu Phe 
    370                 375                 380                 


Arg Ala Leu Gln Phe Ser Leu Met Leu Cys Ala Phe Val Gly Ala Leu 
385                 390                 395                 400 


Gly Gly Ala Ala Phe Leu Gly Thr Ala Ile Phe Ile Glu Ala Asp Arg 
                405                 410                 415     


Arg Arg Ala Gln Leu His Val Gln Gly Leu Leu His Glu Ala Gly Ser 
            420                 425                 430         


Thr Asp Asp Arg Ile Val Val Pro Gln Arg Gly Arg Ser Thr Arg Val 
        435                 440                 445             


Pro Val Ala Ser Val Leu Ile 
    450                 455 


<210>  1665
<211>  476
<212>  PRT
<213>  Homo sapiens

<400>  1665

Met Ala Gly Ser Asp Thr Ala Pro Phe Leu Ser Gln Ala Asp Asp Pro 
1               5                   10                  15      


Asp Asp Gly Pro Val Pro Gly Thr Pro Gly Leu Pro Gly Ser Thr Gly 
            20                  25                  30          


Asn Pro Lys Ser Glu Glu Pro Glu Val Pro Asp Gln Glu Gly Leu Gln 
        35                  40                  45              


Arg Ile Thr Gly Leu Ser Pro Gly Arg Ser Ala Leu Ile Val Ala Val 
    50                  55                  60                  


Leu Cys Tyr Ile Asn Leu Leu Asn Tyr Met Asp Arg Phe Thr Val Ala 
65                  70                  75                  80  


Gly Val Leu Pro Asp Ile Glu Gln Phe Phe Asn Ile Gly Asp Ser Ser 
                85                  90                  95      


Ser Gly Leu Ile Gln Thr Val Phe Ile Ser Ser Tyr Met Val Leu Ala 
            100                 105                 110         


Pro Val Phe Gly Tyr Leu Gly Asp Arg Tyr Asn Arg Lys Tyr Leu Met 
        115                 120                 125             


Cys Gly Gly Ile Ala Phe Trp Ser Leu Val Thr Leu Gly Ser Ser Phe 
    130                 135                 140                 


Ile Pro Gly Glu His Phe Trp Leu Leu Leu Leu Thr Arg Gly Leu Val 
145                 150                 155                 160 


Gly Val Gly Glu Ala Ser Tyr Ser Thr Ile Ala Pro Thr Leu Ile Ala 
                165                 170                 175     


Asp Leu Phe Val Ala Asp Gln Arg Ser Arg Met Leu Ser Ile Phe Tyr 
            180                 185                 190         


Phe Ala Ile Pro Val Gly Ser Gly Leu Gly Tyr Ile Ala Gly Ser Lys 
        195                 200                 205             


Val Lys Asp Met Ala Gly Asp Trp His Trp Ala Leu Arg Val Thr Pro 
    210                 215                 220                 


Gly Leu Gly Val Val Ala Val Leu Leu Leu Phe Leu Val Val Arg Glu 
225                 230                 235                 240 


Pro Pro Arg Gly Ala Val Glu Arg His Ser Asp Leu Pro Pro Leu Asn 
                245                 250                 255     


Pro Thr Ser Trp Trp Ala Asp Leu Arg Ala Leu Ala Arg Asn Leu Ile 
            260                 265                 270         


Phe Gly Leu Ile Thr Cys Leu Thr Gly Val Leu Gly Val Gly Leu Gly 
        275                 280                 285             


Val Glu Ile Ser Arg Arg Leu Arg His Ser Asn Pro Arg Ala Asp Pro 
    290                 295                 300                 


Leu Val Cys Ala Thr Gly Leu Leu Gly Ser Ala Pro Phe Leu Phe Leu 
305                 310                 315                 320 


Ser Leu Ala Cys Ala Arg Gly Ser Ile Val Ala Thr Tyr Ile Phe Ile 
                325                 330                 335     


Phe Ile Gly Glu Thr Leu Leu Ser Met Asn Trp Ala Ile Val Ala Asp 
            340                 345                 350         


Ile Leu Leu Tyr Val Val Ile Pro Thr Arg Arg Ser Thr Ala Glu Ala 
        355                 360                 365             


Phe Gln Ile Val Leu Ser His Leu Leu Gly Asp Ala Gly Ser Pro Tyr 
    370                 375                 380                 


Leu Ile Gly Leu Ile Ser Asp Arg Leu Arg Arg Asn Trp Pro Pro Ser 
385                 390                 395                 400 


Phe Leu Ser Glu Phe Arg Ala Leu Gln Phe Ser Leu Met Leu Cys Ala 
                405                 410                 415     


Phe Val Gly Ala Leu Gly Gly Ala Ala Phe Leu Gly Thr Ala Ile Phe 
            420                 425                 430         


Ile Glu Ala Asp Arg Arg Arg Ala Gln Leu His Val Gln Gly Leu Leu 
        435                 440                 445             


His Glu Ala Gly Ser Thr Asp Asp Arg Ile Val Val Pro Gln Arg Gly 
    450                 455                 460                 


Arg Ser Thr Arg Val Pro Val Ala Ser Val Leu Ile 
465                 470                 475     


<210>  1666
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  1666

Met Asp Phe Trp Leu Trp Pro Leu Tyr Phe Leu Pro Glu Tyr Glu Pro 
1               5                   10                  15      


Ser Trp Glu Glu Gln Pro Met Pro Glu Thr Pro Lys Trp Phe His Leu 
            20                  25                  30          


Pro Tyr Leu Phe Gln Met Pro Ala Tyr Ala Ser Ser Ser Lys Phe Val 
        35                  40                  45              


Thr Arg Val Thr Thr Pro Ala Gln Arg Gly Lys Val Pro Pro Val His 
    50                  55                  60                  


His Ser Ser Pro Thr Thr Gln Ile Thr His Arg Pro Arg Val Ser Arg 
65                  70                  75                  80  


Ala Ser Ser Val Ala Gly Asp Lys Pro Arg Thr Phe Leu Pro Ser Thr 
                85                  90                  95      


Thr Ala Ser Lys Ile Ser Ala Leu Glu Gly Leu Leu Lys Pro Gln Thr 
            100                 105                 110         


Pro Ser Tyr Asn His His Thr Arg Leu His Arg Gln Arg Ala Leu Asp 
        115                 120                 125             


Tyr Gly Ser Gln Ser Gly Arg Glu Gly Gln Gly Phe His Ile Leu Ile 
    130                 135                 140                 


Pro Thr Ile Leu Gly Leu Phe Leu Leu Ala Leu Leu Gly Leu Val Val 
145                 150                 155                 160 


Lys Arg Ala Val Glu Arg Arg Lys Ala Leu Ser Arg Arg Ala Arg Arg 
                165                 170                 175     


Leu Ala Val Arg Met Arg Ala Leu Glu Ser Ser Gln Arg Pro Arg Gly 
            180                 185                 190         


Ser Pro Arg Pro Arg Ser Gln Asn Asn Ile Tyr Ser Ala Cys Pro Arg 
        195                 200                 205             


Arg Ala Arg Gly Ala Asp Ala Ala Gly Thr Gly Glu Ala Pro Val Pro 
    210                 215                 220                 


Gly Pro Gly Ala Pro Leu Pro Pro Ala Pro Leu Gln Val Ser Glu Ser 
225                 230                 235                 240 


Pro Trp Leu His Ala Pro Ser Leu Lys Thr Ser Cys Glu Tyr Val Ser 
                245                 250                 255     


Leu Tyr His Gln Pro Ala Ala Met Met Glu Asp Ser Asp Ser Asp Asp 
            260                 265                 270         


Tyr Ile Asn Val Pro Ala 
        275             


<210>  1667
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  1667

Met Asp Phe Trp Leu Trp Pro Leu Tyr Phe Leu Pro Glu Tyr Glu Pro 
1               5                   10                  15      


Ser Trp Glu Glu Gln Pro Met Pro Glu Thr Pro Lys Trp Phe His Leu 
            20                  25                  30          


Pro Tyr Leu Phe Gln Met Pro Ala Tyr Ala Ser Ser Ser Lys Phe Val 
        35                  40                  45              


Thr Arg Val Thr Thr Pro Ala Gln Arg Gly Lys Val Pro Pro Val His 
    50                  55                  60                  


His Ser Ser Pro Thr Thr Gln Ile Thr His Arg Pro Arg Val Ser Arg 
65                  70                  75                  80  


Ala Ser Ser Val Ala Gly Asp Lys Pro Arg Thr Phe Leu Pro Ser Thr 
                85                  90                  95      


Thr Ala Ser Lys Ile Ser Ala Leu Glu Gly Leu Leu Lys Pro Gln Thr 
            100                 105                 110         


Pro Ser Tyr Asn His His Thr Arg Leu His Arg Gln Arg Ala Leu Asp 
        115                 120                 125             


Tyr Gly Ser Gln Ser Gly Arg Glu Gly Gln Gly Phe His Ile Leu Ile 
    130                 135                 140                 


Pro Thr Ile Leu Gly Leu Phe Leu Leu Ala Leu Leu Gly Leu Val Val 
145                 150                 155                 160 


Lys Arg Ala Val Glu Arg Arg Lys Ala Leu Ser Arg Arg Ala Arg Arg 
                165                 170                 175     


Leu Ala Val Arg Met Arg Ala Leu Glu Ser Ser Gln Arg Pro Arg Gly 
            180                 185                 190         


Ser Pro Arg Pro Arg Ser Gln Asn Asn Ile Tyr Ser Ala Cys Pro Arg 
        195                 200                 205             


Arg Ala Arg Gly Ala Asp Ala Ala Gly Thr Gly Glu Ala Pro Val Pro 
    210                 215                 220                 


Gly Pro Gly Ala Pro Leu Pro Pro Ala Pro Leu Gln Val Ser Glu Ser 
225                 230                 235                 240 


Pro Trp Leu His Ala Pro Ser Leu Lys Thr Ser Cys Glu Tyr Val Ser 
                245                 250                 255     


Leu Tyr His Gln Pro Ala Ala Met Met Glu Asp Ser Asp Ser Asp Asp 
            260                 265                 270         


Tyr Ile Asn Val Pro Ala 
        275             


<210>  1668
<211>  646
<212>  PRT
<213>  Homo sapiens

<400>  1668

Met Ala Glu Lys Ala Leu Glu Ala Val Gly Cys Gly Leu Gly Pro Gly 
1               5                   10                  15      


Ala Val Ala Met Ala Val Thr Leu Glu Asp Gly Ala Glu Pro Pro Val 
            20                  25                  30          


Leu Thr Thr His Leu Lys Lys Val Glu Asn His Ile Thr Glu Ala Gln 
        35                  40                  45              


Arg Phe Ser His Leu Pro Lys Arg Ser Ala Val Asp Ile Glu Phe Val 
    50                  55                  60                  


Glu Leu Ser Tyr Ser Val Arg Glu Gly Pro Cys Trp Arg Lys Arg Gly 
65                  70                  75                  80  


Tyr Lys Thr Leu Leu Lys Cys Leu Ser Gly Lys Phe Cys Arg Arg Glu 
                85                  90                  95      


Leu Ile Gly Ile Met Gly Pro Ser Gly Ala Gly Lys Ser Thr Phe Met 
            100                 105                 110         


Asn Ile Leu Ala Gly Tyr Arg Glu Ser Gly Met Lys Gly Gln Ile Leu 
        115                 120                 125             


Val Asn Gly Arg Pro Arg Glu Leu Arg Thr Phe Arg Lys Met Ser Cys 
    130                 135                 140                 


Tyr Ile Met Gln Asp Asp Met Leu Leu Pro His Leu Thr Val Leu Glu 
145                 150                 155                 160 


Ala Met Met Val Ser Ala Asn Leu Lys Leu Ser Glu Lys Gln Glu Val 
                165                 170                 175     


Lys Lys Glu Leu Val Thr Glu Ile Leu Thr Ala Leu Gly Leu Met Ser 
            180                 185                 190         


Cys Ser His Thr Arg Thr Ala Leu Leu Ser Gly Gly Gln Arg Lys Arg 
        195                 200                 205             


Leu Ala Ile Ala Leu Glu Leu Val Asn Asn Pro Pro Val Met Phe Phe 
    210                 215                 220                 


Asp Glu Pro Thr Ser Gly Leu Asp Ser Ala Ser Cys Phe Gln Val Val 
225                 230                 235                 240 


Ser Leu Met Lys Ser Leu Ala Gln Gly Gly Arg Thr Ile Ile Cys Thr 
                245                 250                 255     


Ile His Gln Pro Ser Ala Lys Leu Phe Glu Met Phe Asp Lys Leu Tyr 
            260                 265                 270         


Ile Leu Ser Gln Gly Gln Cys Ile Phe Lys Gly Val Val Thr Asn Leu 
        275                 280                 285             


Ile Pro Tyr Leu Lys Gly Leu Gly Leu His Cys Pro Thr Tyr His Asn 
    290                 295                 300                 


Pro Ala Asp Phe Ile Ile Glu Val Ala Ser Gly Glu Tyr Gly Asp Leu 
305                 310                 315                 320 


Asn Pro Met Leu Phe Arg Ala Val Gln Asn Gly Leu Cys Ala Met Ala 
                325                 330                 335     


Glu Lys Lys Ser Ser Pro Glu Lys Asn Glu Val Pro Ala Pro Cys Pro 
            340                 345                 350         


Pro Cys Pro Pro Glu Val Asp Pro Ile Glu Ser His Thr Phe Ala Thr 
        355                 360                 365             


Ser Thr Leu Thr Gln Phe Cys Ile Leu Phe Lys Arg Thr Phe Leu Ser 
    370                 375                 380                 


Ile Leu Arg Asp Thr Val Leu Thr His Leu Arg Phe Met Ser His Val 
385                 390                 395                 400 


Val Ile Gly Val Leu Ile Gly Leu Leu Tyr Leu His Ile Gly Asp Asp 
                405                 410                 415     


Ala Ser Lys Val Phe Asn Asn Thr Gly Cys Leu Phe Phe Ser Met Leu 
            420                 425                 430         


Phe Leu Met Phe Ala Ala Leu Met Pro Thr Val Leu Thr Phe Pro Leu 
        435                 440                 445             


Glu Met Ala Val Phe Met Arg Glu His Leu Asn Tyr Trp Tyr Ser Leu 
    450                 455                 460                 


Lys Ala Tyr Tyr Leu Ala Lys Thr Met Ala Asp Val Pro Phe Gln Val 
465                 470                 475                 480 


Val Cys Pro Val Val Tyr Cys Ser Ile Val Tyr Trp Met Thr Gly Gln 
                485                 490                 495     


Pro Ala Glu Thr Ser Arg Phe Leu Leu Phe Ser Ala Leu Ala Thr Ala 
            500                 505                 510         


Thr Ala Leu Val Ala Gln Ser Leu Gly Leu Leu Ile Gly Ala Ala Ser 
        515                 520                 525             


Asn Ser Leu Gln Val Ala Thr Phe Val Gly Pro Val Thr Ala Ile Pro 
    530                 535                 540                 


Val Leu Leu Phe Ser Gly Phe Phe Val Ser Phe Lys Thr Ile Pro Thr 
545                 550                 555                 560 


Tyr Leu Gln Trp Ser Ser Tyr Leu Ser Tyr Val Arg Tyr Gly Phe Glu 
                565                 570                 575     


Gly Val Ile Leu Thr Ile Tyr Gly Met Glu Arg Gly Asp Leu Thr Cys 
            580                 585                 590         


Leu Glu Glu Arg Cys Pro Phe Arg Glu Pro Gln Ser Ile Leu Arg Ala 
        595                 600                 605             


Leu Asp Val Glu Asp Ala Lys Leu Tyr Met Asp Phe Leu Val Leu Gly 
    610                 615                 620                 


Ile Phe Phe Leu Ala Leu Arg Leu Leu Ala Tyr Leu Val Leu Arg Tyr 
625                 630                 635                 640 


Arg Val Lys Ser Glu Arg 
                645     


<210>  1669
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  1669

Met Val Met Gly Leu Gly Val Leu Leu Leu Val Phe Val Leu Gly Leu 
1               5                   10                  15      


Gly Leu Thr Pro Pro Thr Leu Ala Gln Asp Asn Ser Arg Tyr Thr His 
            20                  25                  30          


Phe Leu Thr Gln His Tyr Asp Ala Lys Pro Gln Gly Arg Asp Asp Arg 
        35                  40                  45              


Tyr Cys Glu Ser Ile Met Arg Arg Arg Gly Leu Thr Ser Pro Cys Lys 
    50                  55                  60                  


Asp Ile Asn Thr Phe Ile His Gly Asn Lys Arg Ser Ile Lys Ala Ile 
65                  70                  75                  80  


Cys Glu Asn Lys Asn Gly Asn Pro His Arg Glu Asn Leu Arg Ile Ser 
                85                  90                  95      


Lys Ser Ser Phe Gln Val Thr Thr Cys Lys Leu His Gly Gly Ser Pro 
            100                 105                 110         


Trp Pro Pro Cys Gln Tyr Arg Ala Thr Ala Gly Phe Arg Asn Val Val 
        115                 120                 125             


Val Ala Cys Glu Asn Gly Leu Pro Val His Leu Asp Gln Ser Ile Phe 
    130                 135                 140                 


Arg Arg Pro 
145         


<210>  1670
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  1670

Met Asp Leu Thr Gln Gln Ala Lys Asp Ile Gln Asn Ile Thr Val Gln 
1               5                   10                  15      


Glu Thr Asn Lys Asn Asn Ser Glu Ser Ile Glu Cys Ser Lys Ile Thr 
            20                  25                  30          


Met Asp Leu Lys Phe Asn Asn Ser Arg Lys Tyr Ile Ser Ile Thr Val 
        35                  40                  45              


Pro Ser Lys Thr Gln Thr Met Ser Pro His Ile Lys Ser Val Asp Asp 
    50                  55                  60                  


Val Val Val Leu Gly Met Asn Leu Ser Lys Phe Asn Lys Leu Thr Gln 
65                  70                  75                  80  


Phe Phe Ile Cys Val Ala Gly Val Phe Val Phe Tyr Leu Ile Tyr Gly 
                85                  90                  95      


Tyr Leu Gln Glu Leu Ile Phe Ser Val Glu Gly Phe Lys Ser Cys Gly 
            100                 105                 110         


Trp Tyr Leu Thr Leu Val Gln Phe Ala Phe Tyr Ser Ile Phe Gly Leu 
        115                 120                 125             


Ile Glu Leu Gln Leu Ile Gln Asp Lys Arg Arg Arg Ile Pro Gly Lys 
    130                 135                 140                 


Thr Tyr Met Ile Ile Ala Phe Leu Thr Val Gly Thr Met Gly Leu Ser 
145                 150                 155                 160 


Asn Thr Ser Leu Gly Tyr Leu Asn Tyr Pro Thr Gln Val Ile Phe Lys 
                165                 170                 175     


Cys Cys Lys Leu Ile Pro Val Met Leu Gly Gly Val Phe Ile Gln Gly 
            180                 185                 190         


Lys Arg Tyr Asn Val Ala Asp Val Ser Ala Ala Ile Cys Met Ser Leu 
        195                 200                 205             


Gly Leu Ile Trp Phe Thr Leu Ala Asp Ser Thr Thr Ala Pro Asn Phe 
    210                 215                 220                 


Asn Leu Thr Gly Val Val Leu Ile Ser Leu Ala Leu Cys Ala Asp Ala 
225                 230                 235                 240 


Val Ile Gly Asn Val Gln Glu Lys Ala Met Lys Leu His Asn Ala Ser 
                245                 250                 255     


Asn Ser Glu Met Val Leu Tyr Ser Tyr Ser Ile Gly Phe Val Tyr Ile 
            260                 265                 270         


Leu Leu Gly Leu Thr Cys Thr Ser Gly Leu Gly Pro Ala Val Thr Phe 
        275                 280                 285             


Cys Ala Lys Asn Pro Val Arg Thr Tyr Gly Tyr Ala Phe Leu Phe Ser 
    290                 295                 300                 


Leu Thr Gly Tyr Phe Gly Ile Ser Phe Val Leu Ala Leu Ile Lys Ile 
305                 310                 315                 320 


Phe Gly Ala Leu Ile Ala Val Thr Val Thr Thr Gly Arg Lys Ala Met 
                325                 330                 335     


Thr Ile Val Leu Ser Phe Ile Phe Phe Ala Lys Pro Phe Thr Phe Gln 
            340                 345                 350         


Tyr Val Trp Ser Gly Leu Leu Val Val Leu Gly Ile Phe Leu Asn Val 
        355                 360                 365             


Tyr Ser Lys Asn Met Asp Lys Ile Arg Leu Pro Ser Leu Tyr Asp Leu 
    370                 375                 380                 


Ile Asn Lys Ser Val Glu Ala Arg Lys Ser Arg Thr Leu Ala Gln Thr 
385                 390                 395                 400 


Val 
    


<210>  1671
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  1671

Met Asp Leu Thr Gln Gln Ala Lys Asp Ile Gln Asn Ile Thr Val Gln 
1               5                   10                  15      


Glu Thr Asn Lys Asn Asn Ser Glu Ser Ile Glu Cys Ser Lys Ile Thr 
            20                  25                  30          


Met Asp Leu Lys Phe Asn Asn Ser Arg Lys Tyr Ile Ser Ile Thr Val 
        35                  40                  45              


Pro Ser Lys Thr Gln Thr Met Ser Pro His Ile Lys Ser Val Asp Asp 
    50                  55                  60                  


Val Val Val Leu Gly Met Asn Leu Ser Lys Phe Asn Lys Leu Thr Gln 
65                  70                  75                  80  


Phe Phe Ile Cys Val Ala Gly Val Phe Val Phe Tyr Leu Ile Tyr Gly 
                85                  90                  95      


Tyr Leu Gln Glu Leu Ile Phe Ser Val Glu Gly Phe Lys Ser Cys Gly 
            100                 105                 110         


Trp Tyr Leu Thr Leu Val Gln Phe Ala Phe Tyr Ser Ile Phe Gly Leu 
        115                 120                 125             


Ile Glu Leu Gln Leu Ile Gln Asp Lys Arg Arg Arg Ile Pro Gly Lys 
    130                 135                 140                 


Thr Tyr Met Ile Ile Ala Phe Leu Thr Val Gly Thr Met Gly Leu Ser 
145                 150                 155                 160 


Asn Thr Ser Leu Gly Tyr Leu Asn Tyr Pro Thr Gln Val Ile Phe Lys 
                165                 170                 175     


Cys Cys Lys Leu Ile Pro Val Met Leu Gly Gly Val Phe Ile Gln Gly 
            180                 185                 190         


Lys Arg Tyr Asn Val Ala Asp Val Ser Ala Ala Ile Cys Met Ser Leu 
        195                 200                 205             


Gly Leu Ile Trp Phe Thr Leu Ala Asp Ser Thr Thr Ala Pro Asn Phe 
    210                 215                 220                 


Asn Leu Thr Gly Val Val Leu Ile Ser Leu Ala Leu Cys Ala Asp Ala 
225                 230                 235                 240 


Val Ile Gly Asn Val Gln Glu Lys Ala Met Lys Leu His Asn Ala Ser 
                245                 250                 255     


Asn Ser Glu Met Val Leu Tyr Ser Tyr Ser Ile Gly Phe Val Tyr Ile 
            260                 265                 270         


Leu Leu Gly Leu Thr Cys Thr Ser Gly Leu Gly Pro Ala Val Thr Phe 
        275                 280                 285             


Cys Ala Lys Asn Pro Val Arg Thr Tyr Gly Tyr Ala Phe Leu Phe Ser 
    290                 295                 300                 


Leu Thr Gly Tyr Phe Gly Ile Ser Phe Val Leu Ala Leu Ile Lys Ile 
305                 310                 315                 320 


Phe Gly Ala Leu Ile Ala Val Thr Val Thr Thr Gly Arg Lys Ala Met 
                325                 330                 335     


Thr Ile Val Leu Ser Phe Ile Phe Phe Ala Lys Pro Phe Thr Phe Gln 
            340                 345                 350         


Tyr Val Trp Ser Gly Leu Leu Val Val Leu Gly Ile Phe Leu Asn Val 
        355                 360                 365             


Tyr Ser Lys Asn Met Asp Lys Ile Arg Leu Pro Ser Leu Tyr Asp Leu 
    370                 375                 380                 


Ile Asn Lys Ser Val Glu Ala Arg Lys Ser Arg Thr Leu Ala Gln Thr 
385                 390                 395                 400 


Val 
    


<210>  1672
<211>  1369
<212>  PRT
<213>  Homo sapiens

<400>  1672

Met Ser Pro Cys Gly Arg Lys Met Gly Glu Gly Arg Gln Gln Arg Arg 
1               5                   10                  15      


Ala Pro Val Gly Lys Leu Leu Leu Leu Pro Gly Arg Arg Asp Thr Pro 
            20                  25                  30          


His Gly Arg Ser Gly Ser Ser Gly Ala Arg Thr Gln Arg Ser Leu Leu 
        35                  40                  45              


Trp Leu Leu Val His Val Trp Leu Trp Ala Ala Ser Gly Ser Ser Ala 
    50                  55                  60                  


Gln Leu Phe Asn Leu Thr Leu Ser Val Asp Glu Gly Leu Pro Pro Asp 
65                  70                  75                  80  


Thr Leu Val Gly Asp Ile Arg Ala Gly Leu Pro Ala Ala Gln Gln Gln 
                85                  90                  95      


Glu Gly Ser Gly Phe Phe Leu Ser Glu Asp Ser Asp Asp Ser Pro Leu 
            100                 105                 110         


Leu Asp Asp Phe His Val His Pro Asp Thr Gly Ile Ile Arg Thr Ala 
        115                 120                 125             


Arg Arg Leu Asp Arg Glu Arg Arg Asp His Tyr Ser Phe Val Ala Ala 
    130                 135                 140                 


Thr Leu Leu Gly Ala Val Val Gln Val Glu Ile Arg Val Asn Asp Val 
145                 150                 155                 160 


Asn Asp His Ser Pro Arg Phe Pro Leu Asp Ser Leu Gln Leu Asp Val 
                165                 170                 175     


Ser Glu Leu Ser Pro Pro Gly Thr Ala Phe Arg Leu Pro Val Ala His 
            180                 185                 190         


Asp Pro Asp Ala Gly Leu Phe Ser Thr Gln Gly Tyr Thr Leu Val Gln 
        195                 200                 205             


Pro Ser Asp Leu Pro Lys Asp Pro Ala Gly Pro Phe Phe Gln Leu Arg 
    210                 215                 220                 


Tyr Arg Thr Pro Gly Pro Leu Pro Ser Pro Leu Leu Pro Gly Ser Ser 
225                 230                 235                 240 


Ser Pro Leu Glu Pro Leu Asp Leu Val Leu Leu Arg Arg Leu Asp Arg 
                245                 250                 255     


Glu Glu Ala Ala Ala His Arg Leu Gln Ile Glu Ala Trp Asp Gly Gly 
            260                 265                 270         


Arg Pro Arg Arg Thr Gly Leu Leu Ser Val Glu Leu Arg Val Leu Asp 
        275                 280                 285             


Glu Asn Asp Asn Pro Pro Val Phe Glu Gln Asp Glu Tyr Arg Ala Ala 
    290                 295                 300                 


Val Arg Glu Asp Ala Gln Pro Gly Ala Glu Val Cys Arg Val Arg Ala 
305                 310                 315                 320 


Thr Asp Arg Asp Leu Gly Pro Asn Gly Phe Val Arg Tyr Ser Val Arg 
                325                 330                 335     


Ala Arg Gln Val Pro Gly Ala Gly Ser Gly Gly Gly Ala Leu Gly Asp 
            340                 345                 350         


Ala Ala Tyr Phe Ala Val Glu Glu Leu Ser Gly Val Val Arg Val Trp 
        355                 360                 365             


Arg Pro Leu Asp Arg Glu Ala Gln Ala Trp His Gln Leu Val Val Glu 
    370                 375                 380                 


Ala Arg Asp Gly Gly Ala Glu Pro Glu Val Ala Thr Val Arg Val Ser 
385                 390                 395                 400 


Ile Ala Val Leu Asp Val Asn Asp Asn Arg Pro Ala Ile His Val Leu 
                405                 410                 415     


Phe Leu Thr Glu Gly Gly Val Ala Arg Val Ser Glu Gly Ala Arg Pro 
            420                 425                 430         


Gly Asp Tyr Val Ala Arg Val Ser Val Ser Asp Ala Asp Gly Asp Trp 
        435                 440                 445             


Glu Lys Glu Asp Glu Ala Thr Gly Glu Leu Gly Val Gly Leu Gly Asp 
    450                 455                 460                 


Gly Ser Ile Ser Leu Ser Leu Glu Gly Gly Glu Gly Asp Phe Ala Leu 
465                 470                 475                 480 


Leu Pro Gly Gly Pro Pro Gly Val Phe Phe Leu Cys Val Glu Gly Pro 
                485                 490                 495     


Leu Asp Arg Glu Ser Arg Asp Leu Tyr Glu Leu Leu Leu Val Ala Thr 
            500                 505                 510         


Asp Ala Gly Ser Pro Pro Leu Ser Thr Glu Glu Thr Leu Leu Leu Arg 
        515                 520                 525             


Val Ala Asp Leu Asn Asp Gln Pro Pro Leu Phe Ser Gln Gln His Tyr 
    530                 535                 540                 


Lys Ala Ser Val Ser Glu Ala Ala Ala Pro Gly Thr Val Val Met Trp 
545                 550                 555                 560 


Val Ser Ala Ser Asp Ala Asp Glu Ala Gly Ser Asp His Ala Trp Leu 
                565                 570                 575     


Arg Tyr Thr Val Val Gln Leu Ser Ala Pro Cys Asn Leu Gly Ser Leu 
            580                 585                 590         


Gln Ser Lys Met Val His Thr Ala Glu Cys Gly Pro Ser Phe Ala Ile 
        595                 600                 605             


Asp Ser Glu Ser Gly Ala Ile Ser Thr Ile Arg Thr Leu Asp Arg Glu 
    610                 615                 620                 


Val Gln Glu Ala Val Glu Leu Lys Val Val Ala Gln Asp Leu Gly Glu 
625                 630                 635                 640 


Pro Pro Leu Ser Ala Thr Cys Leu Val Ser Ile Thr Val Asp Asp Val 
                645                 650                 655     


Asn Asp Asn Glu Pro Ile Phe Trp Arg Gln Val Tyr Asn Ala Thr Ile 
            660                 665                 670         


Ala Glu His Ala Pro Val Gly His Cys Phe Leu Gln Val Thr Ala Ser 
        675                 680                 685             


Asp Ala Asp Ser Gly Leu Tyr Gly Phe Ile Glu Tyr Ser Leu Tyr Asp 
    690                 695                 700                 


Gly Phe Leu Ser Tyr Glu Ala Pro Gln Ala Phe Arg Ile Asp Pro His 
705                 710                 715                 720 


Asp Gly Gln Ile Cys Val Ser Gln Asp Ile Asp Arg Glu Arg Asp Pro 
                725                 730                 735     


Ala Thr Tyr Asp Leu Leu Val Glu Ala Lys Asp Gly Gly Gly Leu Ser 
            740                 745                 750         


Ala Gln Ala Phe Val Arg Val Asp Leu Glu Asp Val Asn Asp Asn His 
        755                 760                 765             


Pro Val Phe Asn Pro Ser Thr Tyr Val Thr Ser Ile Ser Asp Glu Thr 
    770                 775                 780                 


Gln Pro Gly Thr Glu Ile Ile Asn Val Leu Ala Thr Asp Gln Asp Ser 
785                 790                 795                 800 


Gly Ile Tyr Gly Thr Val Ala Tyr Glu Leu Ile Pro Gly Asn Val Ser 
                805                 810                 815     


Ser Leu Phe Thr Ile Asp Ser Thr Thr Gly Ile Ile Tyr Leu Thr Leu 
            820                 825                 830         


Pro Leu Ser His Leu Glu Ser Thr Thr Leu Ser Leu Met Val Ser Ala 
        835                 840                 845             


Gln Asp Gly Gly Gly Leu Thr Ala Val Ile Asn Ala Asp Val Thr Ile 
    850                 855                 860                 


His Ile Phe Gln Thr Thr Leu Ala Pro Ala Glu Phe Glu Arg Pro Lys 
865                 870                 875                 880 


Tyr Thr Phe Leu Val Tyr Glu Asp Val Pro Glu Asp Ser Pro Ile Gly 
                885                 890                 895     


Thr Val Lys Ala Arg Glu Pro Leu Asn Ser Ser Glu Pro Ile Phe Tyr 
            900                 905                 910         


Arg Ile Ser Ser Gly Asp Leu Gly Gly Lys Phe Ser Ile His Pro Arg 
        915                 920                 925             


Leu Gly Thr Ile Arg Thr Arg Lys Pro Leu Asp His Glu Thr Gln Pro 
    930                 935                 940                 


Val Val Val Leu Thr Val Gln Ala Gln Leu Gly Ser Ala Pro Ala Cys 
945                 950                 955                 960 


Ser Ser Thr Glu Val Asn Ile Thr Val Met Asp Val Asn Asp Asn His 
                965                 970                 975     


Pro Ala Phe Leu Arg Thr Ser Asp Glu Ile Arg Ile Ser Gln Thr Thr 
            980                 985                 990         


Pro Pro Gly Thr Ala Leu Tyr Leu  Ala Arg Ala Glu Asp  Arg Asp Ser 
        995                 1000                 1005             


Gly Arg  Asn Gly Leu Ile Arg  Tyr Ser Ile Ala Ser  Pro Gln Pro 
    1010                 1015                 1020             


Gly Val  Phe Ala Ile Asp Arg  Ala Leu Gly Val Leu  Phe Leu Asn 
    1025                 1030                 1035             


Gly Ser  Leu Gly Ala Gly Glu  Gln Arg Glu Leu Thr  Leu Thr Leu 
    1040                 1045                 1050             


Arg Ala  Glu Asp Gln Gly Val  His Pro Gln Ala Ala  Leu Leu Val 
    1055                 1060                 1065             


Leu Thr  Val Val Ile Glu Lys  Arg Glu His Ser Pro  Ser Trp Thr 
    1070                 1075                 1080             


Phe Glu  His Leu Val Tyr Gln  Val Glu Val Ser Glu  Ser Leu Ser 
    1085                 1090                 1095             


Pro Met  Thr Gln Met Leu Gln  Thr Gln Ala His Pro  Leu Gly Pro 
    1100                 1105                 1110             


Gln Arg  Ala Ala Ser Pro Leu  Arg Tyr Ser Leu Glu  Pro Ser Val 
    1115                 1120                 1125             


Asp Ser  Ala Met Phe Gly Ile  Arg Pro Tyr Thr Gly  Trp Ile Tyr 
    1130                 1135                 1140             


Leu Arg  Arg Gln Phe Asp Tyr  Glu Ser Thr Gln Thr  Tyr Asn Phe 
    1145                 1150                 1155             


Arg Val  Phe Ala Trp Ile Pro  Glu Asp Gly Phe Leu  Gln Asn Val 
    1160                 1165                 1170             


Ser Thr  Thr Val Ile Val Arg  Val Trp Asp Glu Asn  Asp Asn Ser 
    1175                 1180                 1185             


Pro Thr  Phe Leu His Asp Val  Leu Phe Leu Lys Val  Glu Glu Ser 
    1190                 1195                 1200             


Pro Val  Pro Gln Gly Val Ile  Gly Lys Ile Thr Ala  Ile Asp Met 
    1205                 1210                 1215             


Asp Ser  Gly Lys Asn Gly Gln  Leu Leu Tyr Phe Leu  Leu Ser Asp 
    1220                 1225                 1230             


Gly Lys  Phe Phe Lys Met Asn  Pro Asn Thr Gly Glu  Leu Ile Asn 
    1235                 1240                 1245             


Trp Val  Ala Leu Asp Arg Glu  His Arg Gly His His  Glu Met Thr 
    1250                 1255                 1260             


Val Leu  Val Thr Asp Arg Gly  Ser Pro Pro Arg Asn  Ala Thr Met 
    1265                 1270                 1275             


Ala Val  Tyr Val Ser Val Thr  Asp Ile Asn Asp Asn  Arg Pro Phe 
    1280                 1285                 1290             


Phe Pro  Gln Cys Leu Pro Gly  Lys Glu Leu His Val  Lys Val Leu 
    1295                 1300                 1305             


Glu Gly  Gln Pro Val Asn Met  Leu Val Thr Thr Val  Phe Ala Lys 
    1310                 1315                 1320             


Asp Pro  Asp Glu Gly Asn Asn  Ala Glu Val Thr Tyr  Ser Val Ser 
    1325                 1330                 1335             


Ser Ala  Arg Pro Met Pro Leu  Lys Gly Lys Thr Ala  Phe Gly Lys 
    1340                 1345                 1350             


Gln Ser  Cys Lys Lys Gln Thr  Asn Lys Gln Thr Asn  Lys Ile Leu 
    1355                 1360                 1365             


Thr 
    


<210>  1673
<211>  1369
<212>  PRT
<213>  Homo sapiens

<400>  1673

Met Ser Pro Cys Gly Arg Lys Met Gly Glu Gly Arg Gln Gln Arg Arg 
1               5                   10                  15      


Ala Pro Val Gly Lys Leu Leu Leu Leu Pro Gly Arg Arg Asp Thr Pro 
            20                  25                  30          


His Gly Arg Ser Gly Ser Ser Gly Ala Arg Thr Gln Arg Ser Leu Leu 
        35                  40                  45              


Trp Leu Leu Val His Val Trp Leu Trp Ala Ala Ser Gly Ser Ser Ala 
    50                  55                  60                  


Gln Leu Phe Asn Leu Thr Leu Ser Val Asp Glu Gly Leu Pro Pro Asp 
65                  70                  75                  80  


Thr Leu Val Gly Asp Ile Arg Ala Gly Leu Pro Ala Ala Gln Gln Gln 
                85                  90                  95      


Glu Gly Ser Gly Phe Phe Leu Ser Glu Asp Ser Asp Asp Ser Pro Leu 
            100                 105                 110         


Leu Asp Asp Phe His Val His Pro Asp Thr Gly Ile Ile Arg Thr Ala 
        115                 120                 125             


Arg Arg Leu Asp Arg Glu Arg Arg Asp His Tyr Ser Phe Val Ala Ala 
    130                 135                 140                 


Thr Leu Leu Gly Ala Val Val Gln Val Glu Ile Arg Val Asn Asp Val 
145                 150                 155                 160 


Asn Asp His Ser Pro Arg Phe Pro Leu Asp Ser Leu Gln Leu Asp Val 
                165                 170                 175     


Ser Glu Leu Ser Pro Pro Gly Thr Ala Phe Arg Leu Pro Val Ala His 
            180                 185                 190         


Asp Pro Asp Ala Gly Leu Phe Ser Thr Gln Gly Tyr Thr Leu Val Gln 
        195                 200                 205             


Pro Ser Asp Leu Pro Lys Asp Pro Ala Gly Pro Phe Phe Gln Leu Arg 
    210                 215                 220                 


Tyr Arg Thr Pro Gly Pro Leu Pro Ser Pro Leu Leu Pro Gly Ser Ser 
225                 230                 235                 240 


Ser Pro Leu Glu Pro Leu Asp Leu Val Leu Leu Arg Arg Leu Asp Arg 
                245                 250                 255     


Glu Glu Ala Ala Ala His Arg Leu Gln Ile Glu Ala Trp Asp Gly Gly 
            260                 265                 270         


Arg Pro Arg Arg Thr Gly Leu Leu Ser Val Glu Leu Arg Val Leu Asp 
        275                 280                 285             


Glu Asn Asp Asn Pro Pro Val Phe Glu Gln Asp Glu Tyr Arg Ala Ala 
    290                 295                 300                 


Val Arg Glu Asp Ala Gln Pro Gly Ala Glu Val Cys Arg Val Arg Ala 
305                 310                 315                 320 


Thr Asp Arg Asp Leu Gly Pro Asn Gly Phe Val Arg Tyr Ser Val Arg 
                325                 330                 335     


Ala Arg Gln Val Pro Gly Ala Gly Ser Gly Gly Gly Ala Leu Gly Asp 
            340                 345                 350         


Ala Ala Tyr Phe Ala Val Glu Glu Leu Ser Gly Val Val Arg Val Trp 
        355                 360                 365             


Arg Pro Leu Asp Arg Glu Ala Gln Ala Trp His Gln Leu Val Val Glu 
    370                 375                 380                 


Ala Arg Asp Gly Gly Ala Glu Pro Glu Val Ala Thr Val Arg Val Ser 
385                 390                 395                 400 


Ile Ala Val Leu Asp Val Asn Asp Asn Arg Pro Ala Ile His Val Leu 
                405                 410                 415     


Phe Leu Thr Glu Gly Gly Val Ala Arg Val Ser Glu Gly Ala Arg Pro 
            420                 425                 430         


Gly Asp Tyr Val Ala Arg Val Ser Val Ser Asp Ala Asp Gly Asp Trp 
        435                 440                 445             


Glu Lys Glu Asp Glu Ala Thr Gly Glu Leu Gly Val Gly Leu Gly Asp 
    450                 455                 460                 


Gly Ser Ile Ser Leu Ser Leu Glu Gly Gly Glu Gly Asp Phe Ala Leu 
465                 470                 475                 480 


Leu Pro Gly Gly Pro Pro Gly Val Phe Phe Leu Cys Val Glu Gly Pro 
                485                 490                 495     


Leu Asp Arg Glu Ser Arg Asp Leu Tyr Glu Leu Leu Leu Val Ala Thr 
            500                 505                 510         


Asp Ala Gly Ser Pro Pro Leu Ser Thr Glu Glu Thr Leu Leu Leu Arg 
        515                 520                 525             


Val Ala Asp Leu Asn Asp Gln Pro Pro Leu Phe Ser Gln Gln His Tyr 
    530                 535                 540                 


Lys Ala Ser Val Ser Glu Ala Ala Ala Pro Gly Thr Val Val Met Trp 
545                 550                 555                 560 


Val Ser Ala Ser Asp Ala Asp Glu Ala Gly Ser Asp His Ala Trp Leu 
                565                 570                 575     


Arg Tyr Thr Val Val Gln Leu Ser Ala Pro Cys Asn Leu Gly Ser Leu 
            580                 585                 590         


Gln Ser Lys Met Val His Thr Ala Glu Cys Gly Pro Ser Phe Ala Ile 
        595                 600                 605             


Asp Ser Glu Ser Gly Ala Ile Ser Thr Ile Arg Thr Leu Asp Arg Glu 
    610                 615                 620                 


Val Gln Glu Ala Val Glu Leu Lys Val Val Ala Gln Asp Leu Gly Glu 
625                 630                 635                 640 


Pro Pro Leu Ser Ala Thr Cys Leu Val Ser Ile Thr Val Asp Asp Val 
                645                 650                 655     


Asn Asp Asn Glu Pro Ile Phe Trp Arg Gln Val Tyr Asn Ala Thr Ile 
            660                 665                 670         


Ala Glu His Ala Pro Val Gly His Cys Phe Leu Gln Val Thr Ala Ser 
        675                 680                 685             


Asp Ala Asp Ser Gly Leu Tyr Gly Phe Ile Glu Tyr Ser Leu Tyr Asp 
    690                 695                 700                 


Gly Phe Leu Ser Tyr Glu Ala Pro Gln Ala Phe Arg Ile Asp Pro His 
705                 710                 715                 720 


Asp Gly Gln Ile Cys Val Ser Gln Asp Ile Asp Arg Glu Arg Asp Pro 
                725                 730                 735     


Ala Thr Tyr Asp Leu Leu Val Glu Ala Lys Asp Gly Gly Gly Leu Ser 
            740                 745                 750         


Ala Gln Ala Phe Val Arg Val Asp Leu Glu Asp Val Asn Asp Asn His 
        755                 760                 765             


Pro Val Phe Asn Pro Ser Thr Tyr Val Thr Ser Ile Ser Asp Glu Thr 
    770                 775                 780                 


Gln Pro Gly Thr Glu Ile Ile Asn Val Leu Ala Thr Asp Gln Asp Ser 
785                 790                 795                 800 


Gly Ile Tyr Gly Thr Val Ala Tyr Glu Leu Ile Pro Gly Asn Val Ser 
                805                 810                 815     


Ser Leu Phe Thr Ile Asp Ser Thr Thr Gly Ile Ile Tyr Leu Thr Leu 
            820                 825                 830         


Pro Leu Ser His Leu Glu Ser Thr Thr Leu Ser Leu Met Val Ser Ala 
        835                 840                 845             


Gln Asp Gly Gly Gly Leu Thr Ala Val Ile Asn Ala Asp Val Thr Ile 
    850                 855                 860                 


His Ile Phe Gln Thr Thr Leu Ala Pro Ala Glu Phe Glu Arg Pro Lys 
865                 870                 875                 880 


Tyr Thr Phe Leu Val Tyr Glu Asp Val Pro Glu Asp Ser Pro Ile Gly 
                885                 890                 895     


Thr Val Lys Ala Arg Glu Pro Leu Asn Ser Ser Glu Pro Ile Phe Tyr 
            900                 905                 910         


Arg Ile Ser Ser Gly Asp Leu Gly Gly Lys Phe Ser Ile His Pro Arg 
        915                 920                 925             


Leu Gly Thr Ile Arg Thr Arg Lys Pro Leu Asp His Glu Thr Gln Pro 
    930                 935                 940                 


Val Val Val Leu Thr Val Gln Ala Gln Leu Gly Ser Ala Pro Ala Cys 
945                 950                 955                 960 


Ser Ser Thr Glu Val Asn Ile Thr Val Met Asp Val Asn Asp Asn His 
                965                 970                 975     


Pro Ala Phe Leu Arg Thr Ser Asp Glu Ile Arg Ile Ser Gln Thr Thr 
            980                 985                 990         


Pro Pro Gly Thr Ala Leu Tyr Leu  Ala Arg Ala Glu Asp  Arg Asp Ser 
        995                 1000                 1005             


Gly Arg  Asn Gly Leu Ile Arg  Tyr Ser Ile Ala Ser  Pro Gln Pro 
    1010                 1015                 1020             


Gly Val  Phe Ala Ile Asp Arg  Ala Leu Gly Val Leu  Phe Leu Asn 
    1025                 1030                 1035             


Gly Ser  Leu Gly Ala Gly Glu  Gln Arg Glu Leu Thr  Leu Thr Leu 
    1040                 1045                 1050             


Arg Ala  Glu Asp Gln Gly Val  His Pro Gln Ala Ala  Leu Leu Val 
    1055                 1060                 1065             


Leu Thr  Val Val Ile Glu Lys  Arg Glu His Ser Pro  Ser Trp Thr 
    1070                 1075                 1080             


Phe Glu  His Leu Val Tyr Gln  Val Glu Val Ser Glu  Ser Leu Ser 
    1085                 1090                 1095             


Pro Met  Thr Gln Met Leu Gln  Thr Gln Ala His Pro  Leu Gly Pro 
    1100                 1105                 1110             


Gln Arg  Ala Ala Ser Pro Leu  Arg Tyr Ser Leu Glu  Pro Ser Val 
    1115                 1120                 1125             


Asp Ser  Ala Met Phe Gly Ile  Arg Pro Tyr Thr Gly  Trp Ile Tyr 
    1130                 1135                 1140             


Leu Arg  Arg Gln Phe Asp Tyr  Glu Ser Thr Gln Thr  Tyr Asn Phe 
    1145                 1150                 1155             


Arg Val  Phe Ala Trp Ile Pro  Glu Asp Gly Phe Leu  Gln Asn Val 
    1160                 1165                 1170             


Ser Thr  Thr Val Ile Val Arg  Val Trp Asp Glu Asn  Asp Asn Ser 
    1175                 1180                 1185             


Pro Thr  Phe Leu His Asp Val  Leu Phe Leu Lys Val  Glu Glu Ser 
    1190                 1195                 1200             


Pro Val  Pro Gln Gly Val Ile  Gly Lys Ile Thr Ala  Ile Asp Met 
    1205                 1210                 1215             


Asp Ser  Gly Lys Asn Gly Gln  Leu Leu Tyr Phe Leu  Leu Ser Asp 
    1220                 1225                 1230             


Gly Lys  Phe Phe Lys Met Asn  Pro Asn Thr Gly Glu  Leu Ile Asn 
    1235                 1240                 1245             


Trp Val  Ala Leu Asp Arg Glu  His Arg Gly His His  Glu Met Thr 
    1250                 1255                 1260             


Val Leu  Val Thr Asp Arg Gly  Ser Pro Pro Arg Asn  Ala Thr Met 
    1265                 1270                 1275             


Ala Val  Tyr Val Ser Val Thr  Asp Ile Asn Asp Asn  Arg Pro Phe 
    1280                 1285                 1290             


Phe Pro  Gln Cys Leu Pro Gly  Lys Glu Leu His Val  Lys Val Leu 
    1295                 1300                 1305             


Glu Gly  Gln Pro Val Asn Met  Leu Val Thr Thr Val  Phe Ala Lys 
    1310                 1315                 1320             


Asp Pro  Asp Glu Gly Asn Asn  Ala Glu Val Thr Tyr  Ser Val Ser 
    1325                 1330                 1335             


Ser Ala  Arg Pro Met Pro Leu  Lys Gly Lys Thr Ala  Phe Gly Lys 
    1340                 1345                 1350             


Gln Ser  Cys Lys Lys Gln Thr  Asn Lys Gln Thr Asn  Lys Ile Leu 
    1355                 1360                 1365             


Thr 
    


<210>  1674
<211>  759
<212>  PRT
<213>  Homo sapiens

<400>  1674

Met Glu Ser Arg Ser Ser Pro Arg Leu Glu Cys Ser Gly Ala Ile Ser 
1               5                   10                  15      


Ala His Cys Ser Leu His Leu Pro Asp Ser Ser Asp Phe Gln Leu Ile 
            20                  25                  30          


Phe Val Phe Leu Val Glu Met Gly Phe His His Val Gly Gln Ala Gly 
        35                  40                  45              


Leu Glu Leu Leu Ile Ser Ser Asp Leu Pro Thr Ser Ala Ser Gln Ser 
    50                  55                  60                  


Ala Gly Ile Thr Asp Met Lys Leu Ser Met Lys Asn Asn Ile Ile Asn 
65                  70                  75                  80  


Thr Gln Gln Ser Phe Val Thr Met Pro Asn Val Ile Val Pro Asp Ile 
                85                  90                  95      


Glu Lys Glu Ile Arg Arg Met Glu Asn Gly Ala Cys Ser Ser Phe Ser 
            100                 105                 110         


Glu Asp Asp Asp Ser Ala Ser Thr Ser Glu Glu Ser Glu Asn Glu Asn 
        115                 120                 125             


Pro His Ala Arg Gly Ser Phe Ser Tyr Lys Ser Leu Arg Lys Gly Gly 
    130                 135                 140                 


Pro Ser Gln Arg Glu Gln Tyr Leu Pro Gly Ala Ile Ala Leu Phe Asn 
145                 150                 155                 160 


Val Asn Asn Ser Ser Asn Lys Asp Gln Glu Pro Glu Glu Lys Lys Lys 
                165                 170                 175     


Lys Lys Lys Glu Lys Lys Ser Lys Ser Asp Asp Lys Asn Glu Asn Lys 
            180                 185                 190         


Asn Asp Pro Glu Lys Lys Lys Lys Lys Lys Asp Lys Glu Lys Lys Lys 
        195                 200                 205             


Lys Glu Glu Lys Ser Lys Asp Lys Lys Glu Glu Glu Lys Lys Glu Val 
    210                 215                 220                 


Val Val Ile Asp Pro Ser Gly Asn Thr Tyr Tyr Asn Trp Leu Phe Cys 
225                 230                 235                 240 


Ile Thr Leu Pro Val Met Tyr Asn Trp Thr Met Val Ile Ala Arg Ala 
                245                 250                 255     


Cys Phe Asp Glu Leu Gln Ser Asp Tyr Leu Glu Tyr Trp Leu Ile Leu 
            260                 265                 270         


Asp Tyr Val Ser Asp Ile Val Tyr Leu Ile Asp Met Phe Val Arg Thr 
        275                 280                 285             


Arg Thr Gly Tyr Leu Glu Gln Gly Leu Leu Val Lys Glu Glu Leu Lys 
    290                 295                 300                 


Leu Ile Asn Lys Tyr Lys Ser Asn Leu Gln Phe Lys Leu Asp Val Leu 
305                 310                 315                 320 


Ser Leu Ile Pro Thr Asp Leu Leu Tyr Phe Lys Leu Gly Trp Asn Tyr 
                325                 330                 335     


Pro Glu Ile Arg Leu Asn Arg Leu Leu Arg Phe Ser Arg Met Phe Glu 
            340                 345                 350         


Phe Phe Gln Arg Thr Glu Thr Arg Thr Asn Tyr Pro Asn Ile Phe Arg 
        355                 360                 365             


Ile Ser Asn Leu Val Met Tyr Ile Val Ile Ile Ile His Trp Asn Ala 
    370                 375                 380                 


Cys Val Phe Tyr Ser Ile Ser Lys Ala Ile Gly Phe Gly Asn Asp Thr 
385                 390                 395                 400 


Trp Val Tyr Pro Asp Ile Asn Asp Pro Glu Phe Gly Arg Leu Ala Arg 
                405                 410                 415     


Lys Tyr Val Tyr Ser Leu Tyr Trp Ser Thr Leu Thr Leu Thr Thr Ile 
            420                 425                 430         


Gly Glu Thr Pro Pro Pro Val Arg Asp Ser Glu Tyr Val Phe Val Val 
        435                 440                 445             


Val Asp Phe Leu Ile Gly Val Leu Ile Phe Ala Thr Ile Val Gly Asn 
    450                 455                 460                 


Ile Gly Ser Met Ile Ser Asn Met Asn Ala Ala Arg Ala Glu Phe Gln 
465                 470                 475                 480 


Ala Arg Ile Asp Ala Ile Lys Gln Tyr Met His Phe Arg Asn Val Ser 
                485                 490                 495     


Lys Asp Met Glu Lys Arg Val Ile Lys Trp Phe Asp Tyr Leu Trp Thr 
            500                 505                 510         


Asn Lys Lys Thr Val Asp Glu Lys Glu Val Leu Lys Tyr Leu Pro Asp 
        515                 520                 525             


Lys Leu Arg Ala Glu Ile Ala Ile Asn Val His Leu Asp Thr Leu Lys 
    530                 535                 540                 


Lys Val Arg Ile Phe Ala Asp Cys Glu Ala Gly Leu Leu Val Glu Leu 
545                 550                 555                 560 


Val Leu Lys Leu Gln Pro Gln Val Tyr Ser Pro Gly Asp Tyr Ile Cys 
                565                 570                 575     


Lys Lys Gly Asp Ile Gly Arg Glu Met Tyr Ile Ile Lys Glu Gly Lys 
            580                 585                 590         


Leu Ala Val Val Ala Asp Asp Gly Val Thr Gln Phe Val Val Leu Ser 
        595                 600                 605             


Asp Gly Ser Tyr Phe Gly Glu Ile Ser Ile Leu Asn Ile Lys Gly Ser 
    610                 615                 620                 


Lys Ala Gly Asn Arg Arg Thr Ala Asn Ile Lys Ser Ile Gly Tyr Ser 
625                 630                 635                 640 


Asp Leu Phe Cys Leu Ser Lys Asp Asp Leu Met Glu Ala Leu Thr Glu 
                645                 650                 655     


Tyr Pro Asp Ala Lys Thr Met Leu Glu Glu Lys Gly Lys Gln Ile Leu 
            660                 665                 670         


Met Lys Asp Gly Leu Leu Asp Leu Asn Ile Ala Asn Ala Gly Ser Asp 
        675                 680                 685             


Pro Lys Asp Leu Glu Glu Lys Val Thr Arg Met Glu Gly Ser Val Asp 
    690                 695                 700                 


Leu Leu Gln Thr Arg Phe Ala Arg Ile Leu Ala Glu Tyr Glu Ser Met 
705                 710                 715                 720 


Gln Gln Lys Leu Lys Gln Arg Leu Thr Lys Val Glu Lys Phe Leu Lys 
                725                 730                 735     


Pro Leu Ile Asp Thr Glu Phe Ser Ser Ile Glu Gly Pro Gly Ala Glu 
            740                 745                 750         


Ser Gly Pro Ile Asp Ser Thr 
        755                 


<210>  1675
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  1675

Met Lys Leu Trp Val Ser Ala Leu Leu Met Ala Trp Phe Gly Val Leu 
1               5                   10                  15      


Ser Cys Val Gln Ala Glu Phe Phe Thr Ser Ile Gly His Met Thr Asp 
            20                  25                  30          


Leu Ile Tyr Ala Glu Lys Glu Leu Val Gln Ser Leu Lys Glu Tyr Ile 
        35                  40                  45              


Leu Val Glu Glu Ala Lys Leu Ser Lys Ile Lys Ser Trp Ala Asn Lys 
    50                  55                  60                  


Met Glu Ala Leu Thr Ser Lys Ser Ala Ala Asp Ala Glu Gly Tyr Leu 
65                  70                  75                  80  


Ala His Pro Val Asn Ala Tyr Lys Leu Val Lys Arg Leu Asn Thr Asp 
                85                  90                  95      


Trp Pro Ala Leu Glu Asp Leu Val Leu Gln Asp Ser Ala Ala Gly Phe 
            100                 105                 110         


Ile Ala Asn Leu Ser Val Gln Arg Gln Phe Phe Pro Thr Asp Glu Asp 
        115                 120                 125             


Glu Ile Gly Ala Ala Lys Ala Leu Met Arg Leu Gln Asp Thr Tyr Arg 
    130                 135                 140                 


Leu Asp Pro Gly Thr Ile Ser Arg Gly Glu Leu Pro Gly Thr Lys Tyr 
145                 150                 155                 160 


Gln Ala Met Leu Ser Val Asp Asp Cys Phe Gly Met Gly Arg Ser Ala 
                165                 170                 175     


Tyr Asn Glu Gly Asp Tyr Tyr His Thr Val Leu Trp Met Glu Gln Val 
            180                 185                 190         


Leu Lys Gln Leu Asp Ala Gly Glu Glu Ala Thr Thr Thr Lys Ser Gln 
        195                 200                 205             


Val Leu Asp Tyr Leu Ser Tyr Ala Val Phe Gln Leu Gly Asp Leu His 
    210                 215                 220                 


Arg Ala Leu Glu Leu Thr Arg Arg Leu Leu Ser Leu Asp Pro Ser His 
225                 230                 235                 240 


Glu Arg Ala Gly Gly Asn Leu Arg Tyr Phe Glu Gln Leu Leu Glu Glu 
                245                 250                 255     


Glu Arg Glu Lys Thr Leu Thr Asn Gln Thr Glu Ala Glu Leu Ala Thr 
            260                 265                 270         


Pro Glu Gly Ile Tyr Glu Arg Pro Val Asp Tyr Leu Pro Glu Arg Asp 
        275                 280                 285             


Val Tyr Glu Ser Leu Cys Arg Gly Glu Gly Val Lys Leu Thr Pro Arg 
    290                 295                 300                 


Arg Gln Lys Arg Leu Phe Cys Arg Tyr His His Gly Asn Arg Ala Pro 
305                 310                 315                 320 


Gln Leu Leu Ile Ala Pro Phe Lys Glu Glu Asp Glu Trp Asp Ser Pro 
                325                 330                 335     


His Ile Val Arg Tyr Tyr Asp Val Met Ser Asp Glu Glu Ile Glu Arg 
            340                 345                 350         


Ile Lys Glu Ile Ala Lys Pro Lys Leu Ala Arg Ala Thr Val Arg Asp 
        355                 360                 365             


Pro Lys Thr Gly Val Leu Thr Val Ala Ser Tyr Arg Val Ser Lys Ser 
    370                 375                 380                 


Ser Trp Leu Glu Glu Asp Asp Asp Pro Val Val Ala Arg Val Asn Arg 
385                 390                 395                 400 


Arg Met Gln His Ile Thr Gly Leu Thr Val Lys Thr Ala Glu Leu Leu 
                405                 410                 415     


Gln Val Ala Asn Tyr Gly Val Gly Gly Gln Tyr Glu Pro His Phe Asp 
            420                 425                 430         


Phe Ser Arg Arg Pro Phe Asp Ser Gly Leu Lys Thr Glu Gly Asn Arg 
        435                 440                 445             


Leu Ala Thr Phe Leu Asn Tyr Met Ser Asp Val Glu Ala Gly Gly Ala 
    450                 455                 460                 


Thr Val Phe Pro Asp Leu Gly Ala Ala Ile Trp Pro Lys Lys Gly Thr 
465                 470                 475                 480 


Ala Val Phe Trp Tyr Asn Leu Leu Arg Ser Gly Glu Gly Asp Tyr Arg 
                485                 490                 495     


Thr Arg His Ala Ala Cys Pro Val Leu Val Gly Cys Lys Trp Val Ser 
            500                 505                 510         


Asn Lys Trp Phe His Glu Arg Gly Gln Glu Phe Leu Arg Pro Cys Gly 
        515                 520                 525             


Ser Thr Glu Val Asp 
    530             


<210>  1676
<211>  535
<212>  PRT
<213>  Homo sapiens

<400>  1676

Met Lys Leu Trp Val Ser Ala Leu Leu Met Ala Trp Phe Gly Val Leu 
1               5                   10                  15      


Ser Cys Val Gln Ala Glu Phe Phe Thr Ser Ile Gly His Met Thr Asp 
            20                  25                  30          


Leu Ile Tyr Ala Glu Lys Glu Leu Val Gln Ser Leu Lys Glu Tyr Ile 
        35                  40                  45              


Leu Val Glu Glu Ala Lys Leu Ser Lys Ile Lys Ser Trp Ala Asn Lys 
    50                  55                  60                  


Met Glu Ala Leu Thr Ser Lys Ser Ala Ala Asp Ala Glu Gly Tyr Leu 
65                  70                  75                  80  


Ala His Pro Val Asn Ala Tyr Lys Leu Val Lys Arg Leu Asn Thr Asp 
                85                  90                  95      


Trp Pro Ala Leu Glu Asp Leu Val Leu Gln Asp Ser Ala Ala Gly Phe 
            100                 105                 110         


Ile Ala Asn Leu Ser Val Gln Arg Gln Phe Phe Pro Thr Asp Glu Asp 
        115                 120                 125             


Glu Ile Gly Ala Ala Lys Ala Leu Met Arg Leu Gln Asp Thr Tyr Arg 
    130                 135                 140                 


Leu Asp Pro Gly Thr Ile Ser Arg Gly Glu Leu Pro Gly Thr Lys Tyr 
145                 150                 155                 160 


Gln Ala Met Leu Ser Val Asp Asp Cys Phe Gly Met Gly Arg Ser Ala 
                165                 170                 175     


Tyr Asn Glu Gly Asp Tyr Tyr His Thr Val Leu Trp Met Glu Gln Val 
            180                 185                 190         


Leu Lys Gln Leu Asp Ala Gly Glu Glu Ala Thr Thr Thr Lys Ser Gln 
        195                 200                 205             


Val Leu Asp Tyr Leu Ser Tyr Ala Val Phe Gln Leu Gly Asp Leu His 
    210                 215                 220                 


Arg Ala Leu Glu Leu Thr Arg Arg Leu Leu Ser Leu Asp Pro Ser His 
225                 230                 235                 240 


Glu Arg Ala Gly Gly Asn Leu Arg Tyr Phe Glu Gln Leu Leu Glu Glu 
                245                 250                 255     


Glu Arg Glu Lys Thr Leu Thr Asn Gln Thr Glu Ala Glu Leu Ala Thr 
            260                 265                 270         


Pro Glu Gly Ile Tyr Glu Arg Pro Val Asp Tyr Leu Pro Glu Arg Asp 
        275                 280                 285             


Val Tyr Glu Ser Leu Cys Arg Gly Glu Gly Val Lys Leu Thr Pro Arg 
    290                 295                 300                 


Arg Gln Lys Arg Leu Phe Cys Arg Tyr His His Gly Asn Arg Ala Pro 
305                 310                 315                 320 


Gln Leu Leu Ile Ala Pro Phe Lys Glu Glu Asp Glu Trp Asp Ser Pro 
                325                 330                 335     


His Ile Val Arg Tyr Tyr Asp Val Met Ser Asp Glu Glu Ile Glu Arg 
            340                 345                 350         


Ile Lys Glu Ile Ala Lys Pro Lys Leu Ala Arg Ala Thr Val Arg Asp 
        355                 360                 365             


Pro Lys Thr Gly Val Leu Thr Val Ala Ser Tyr Arg Val Ser Lys Ser 
    370                 375                 380                 


Ser Trp Leu Glu Glu Asp Asp Asp Pro Val Val Ala Arg Val Asn Arg 
385                 390                 395                 400 


Arg Met Gln His Ile Thr Gly Leu Thr Val Lys Thr Ala Glu Leu Leu 
                405                 410                 415     


Gln Val Ala Asn Tyr Gly Val Gly Gly Gln Tyr Glu Pro His Phe Asp 
            420                 425                 430         


Phe Ser Arg Asn Asp Glu Arg Asp Thr Phe Lys His Leu Gly Thr Gly 
        435                 440                 445             


Asn Arg Val Ala Thr Phe Leu Asn Tyr Met Ser Asp Val Glu Ala Gly 
    450                 455                 460                 


Gly Ala Thr Val Phe Pro Asp Leu Gly Ala Ala Ile Trp Pro Lys Lys 
465                 470                 475                 480 


Gly Thr Ala Val Phe Trp Tyr Asn Leu Leu Arg Ser Gly Glu Gly Asp 
                485                 490                 495     


Tyr Arg Thr Arg His Ala Ala Cys Pro Val Leu Val Gly Cys Lys Trp 
            500                 505                 510         


Val Ser Asn Lys Trp Phe His Glu Arg Gly Gln Glu Phe Leu Arg Pro 
        515                 520                 525             


Cys Gly Ser Thr Glu Val Asp 
    530                 535 


<210>  1677
<211>  791
<212>  PRT
<213>  Homo sapiens

<400>  1677

Met Ser Gln Pro Arg Pro Arg Tyr Val Val Asp Arg Ala Ala Tyr Ser 
1               5                   10                  15      


Leu Thr Leu Phe Asp Asp Glu Phe Glu Lys Lys Asp Arg Thr Tyr Pro 
            20                  25                  30          


Val Gly Glu Lys Leu Arg Asn Ala Phe Arg Cys Ser Ser Ala Lys Ile 
        35                  40                  45              


Lys Ala Val Val Phe Gly Leu Leu Pro Val Leu Ser Trp Leu Pro Lys 
    50                  55                  60                  


Tyr Lys Ile Lys Asp Tyr Ile Ile Pro Asp Leu Leu Gly Gly Leu Ser 
65                  70                  75                  80  


Gly Gly Ser Ile Gln Val Pro Gln Gly Met Ala Phe Ala Leu Leu Ala 
                85                  90                  95      


Asn Leu Pro Ala Val Asn Gly Leu Tyr Ser Ser Phe Phe Pro Leu Leu 
            100                 105                 110         


Thr Tyr Phe Phe Leu Gly Gly Val His Gln Met Val Pro Gly Thr Phe 
        115                 120                 125             


Ala Val Ile Ser Ile Leu Val Gly Asn Ile Cys Leu Gln Leu Ala Pro 
    130                 135                 140                 


Glu Ser Lys Phe Gln Val Phe Asn Asn Ala Thr Asn Glu Ser Tyr Val 
145                 150                 155                 160 


Asp Thr Ala Ala Met Glu Ala Glu Arg Leu His Val Ser Ala Thr Leu 
                165                 170                 175     


Ala Cys Leu Thr Ala Ile Ile Gln Met Gly Leu Gly Phe Met Gln Phe 
            180                 185                 190         


Gly Phe Val Ala Ile Tyr Leu Ser Glu Ser Phe Ile Arg Gly Phe Met 
        195                 200                 205             


Thr Ala Ala Gly Leu Gln Ile Leu Ile Ser Val Leu Lys Tyr Ile Phe 
    210                 215                 220                 


Gly Leu Thr Ile Pro Ser Tyr Thr Gly Pro Gly Ser Ile Val Phe Thr 
225                 230                 235                 240 


Phe Ile Asp Ile Cys Lys Asn Leu Pro His Thr Asn Ile Ala Ser Leu 
                245                 250                 255     


Ile Phe Ala Leu Ile Ser Gly Ala Phe Leu Val Leu Val Lys Glu Leu 
            260                 265                 270         


Asn Ala Arg Tyr Met His Lys Ile Arg Phe Pro Ile Pro Thr Glu Met 
        275                 280                 285             


Ile Val Val Val Val Ala Thr Ala Ile Ser Gly Gly Cys Lys Met Pro 
    290                 295                 300                 


Lys Lys Tyr His Met Gln Ile Val Gly Glu Ile Gln Arg Gly Phe Pro 
305                 310                 315                 320 


Thr Pro Val Ser Pro Val Val Ser Gln Trp Lys Asp Met Ile Gly Thr 
                325                 330                 335     


Ala Phe Ser Leu Ala Ile Val Ser Tyr Val Ile Asn Leu Ala Met Gly 
            340                 345                 350         


Arg Thr Leu Ala Asn Lys His Gly Tyr Asp Val Asp Ser Asn Gln Glu 
        355                 360                 365             


Met Ile Ala Leu Gly Cys Ser Asn Phe Phe Gly Ser Phe Phe Lys Ile 
    370                 375                 380                 


His Val Ile Cys Cys Ala Leu Ser Val Thr Leu Ala Val Asp Gly Ala 
385                 390                 395                 400 


Gly Gly Lys Ser Gln Val Ala Ser Leu Cys Val Ser Leu Val Val Met 
                405                 410                 415     


Ile Thr Met Leu Val Leu Gly Ile Tyr Leu Tyr Pro Leu Pro Lys Ser 
            420                 425                 430         


Val Leu Gly Ala Leu Ile Ala Val Asn Leu Lys Asn Ser Leu Lys Gln 
        435                 440                 445             


Leu Thr Asp Pro Tyr Tyr Leu Trp Arg Lys Ser Lys Leu Asp Cys Cys 
    450                 455                 460                 


Ile Trp Val Val Ser Phe Leu Ser Ser Phe Phe Leu Ser Leu Pro Tyr 
465                 470                 475                 480 


Gly Val Ala Val Gly Val Ala Phe Ser Val Leu Val Val Val Phe Gln 
                485                 490                 495     


Thr Gln Phe Arg Asn Gly Tyr Ala Leu Ala Gln Val Met Asp Thr Asp 
            500                 505                 510         


Ile Tyr Val Asn Pro Lys Thr Tyr Asn Arg Ala Gln Asp Ile Gln Gly 
        515                 520                 525             


Ile Lys Ile Ile Thr Tyr Cys Ser Pro Leu Tyr Phe Ala Asn Ser Glu 
    530                 535                 540                 


Ile Phe Arg Gln Lys Val Ile Ala Lys Thr Gly Met Asp Pro Gln Lys 
545                 550                 555                 560 


Val Leu Leu Ala Lys Gln Lys Tyr Leu Lys Lys Gln Glu Lys Arg Arg 
                565                 570                 575     


Met Arg Pro Thr Gln Gln Arg Arg Ser Leu Phe Met Lys Thr Lys Thr 
            580                 585                 590         


Val Ser Leu Gln Glu Leu Gln Gln Asp Phe Glu Asn Ala Pro Pro Thr 
        595                 600                 605             


Asp Pro Asn Asn Asn Gln Thr Pro Ala Asn Gly Thr Ser Val Ser Tyr 
    610                 615                 620                 


Ile Thr Phe Ser Pro Asp Ser Ser Ser Pro Ala Gln Ser Glu Pro Pro 
625                 630                 635                 640 


Ala Ser Ala Glu Ala Pro Gly Glu Pro Ser Asp Met Leu Ala Ser Val 
                645                 650                 655     


Pro Pro Phe Val Thr Phe His Thr Leu Ile Leu Asp Met Ser Gly Val 
            660                 665                 670         


Ser Phe Val Asp Leu Met Gly Ile Lys Ala Leu Ala Lys Leu Ser Ser 
        675                 680                 685             


Thr Tyr Gly Lys Ile Gly Val Lys Val Phe Leu Val Asn Ile His Ala 
    690                 695                 700                 


Gln Val Tyr Asn Asp Ile Ser His Gly Gly Val Phe Glu Asp Gly Ser 
705                 710                 715                 720 


Leu Glu Cys Lys His Val Phe Pro Ser Ile His Asp Ala Val Leu Phe 
                725                 730                 735     


Ala Gln Ala Asn Ala Arg Asp Val Thr Pro Gly His Asn Phe Gln Gly 
            740                 745                 750         


Ala Pro Gly Asp Ala Glu Leu Ser Leu Tyr Asp Ser Glu Glu Asp Ile 
        755                 760                 765             


Arg Ser Tyr Trp Asp Leu Glu Gln Glu Met Phe Gly Ser Met Phe His 
    770                 775                 780                 


Ala Glu Thr Leu Thr Ala Leu 
785                 790     


<210>  1678
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  1678

Met Arg Pro Ala Asp Leu Leu Gln Leu Val Leu Leu Leu Asp Leu Pro 
1               5                   10                  15      


Arg Asp Leu Gly Gly Met Gly Cys Ser Ser Pro Pro Cys Glu Cys His 
            20                  25                  30          


Gln Glu Glu Asp Phe Arg Val Thr Cys Lys Asp Ile Gln Arg Ile Pro 
        35                  40                  45              


Ser Leu Pro Pro Ser Thr Gln Thr Leu Lys Leu Ile Glu Thr His Leu 
    50                  55                  60                  


Arg Thr Ile Pro Ser His Ala Phe Ser Asn Leu Pro Asn Ile Ser Arg 
65                  70                  75                  80  


Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu Ser His Ser 
                85                  90                  95      


Phe Tyr Asn Leu Ser Lys Val Thr His Ile Glu Ile Arg Asn Thr Arg 
            100                 105                 110         


Asn Leu Thr Tyr Ile Asp Pro Asp Ala Leu Lys Glu Leu Pro Leu Leu 
        115                 120                 125             


Lys Phe Leu Gly Ile Phe Asn Thr Gly Leu Lys Met Phe Pro Asp Leu 
    130                 135                 140                 


Thr Lys Val Tyr Ser Thr Asp Ile Phe Phe Ile Leu Glu Ile Thr Asp 
145                 150                 155                 160 


Asn Pro Tyr Met Thr Ser Ile Pro Val Asn Ala Phe Gln Gly Leu Cys 
                165                 170                 175     


Asn Glu Thr Leu Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Val 
            180                 185                 190         


Gln Gly Tyr Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu Asn 
        195                 200                 205             


Lys Asn Lys Tyr Leu Thr Val Ile Asp Lys Asp Ala Phe Gly Gly Val 
    210                 215                 220                 


Tyr Ser Gly Pro Ser Leu Leu Val Glu Asn Val Ala Val Ser Gly Lys 
225                 230                 235                 240 


Gly Phe Cys Lys Ser Leu Phe Ser Trp Leu Tyr Arg Leu Pro Leu Gly 
                245                 250                 255     


Arg Lys Ser Leu Ser Phe Glu Thr Gln Lys Ala Pro Arg Ser Ser Met 
            260                 265                 270         


Pro Ser 
        


<210>  1679
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  1679

Met Gly Ile Lys Phe Leu Glu Val Ile Lys Pro Phe Cys Ala Val Leu 
1               5                   10                  15      


Pro Glu Ile Gln Lys Pro Glu Arg Lys Ile Gln Phe Arg Glu Lys Val 
            20                  25                  30          


Leu Trp Thr Ala Ile Thr Leu Phe Ile Phe Leu Val Cys Cys Gln Ile 
        35                  40                  45              


Pro Leu Phe Gly Ile Met Ser Ser Asp Ser Ala Asp Pro Phe Tyr Trp 
    50                  55                  60                  


Met Arg Val Ile Leu Ala Ser Asn Arg Gly Thr Leu Met Glu Leu Gly 
65                  70                  75                  80  


Ile Ser Pro Ile Val Thr Ser Gly Leu Ile Met Gln Leu Leu Ala Gly 
                85                  90                  95      


Ala Lys Ile Ile Glu Val Gly Asp Thr Pro Lys Asp Arg Ala Leu Phe 
            100                 105                 110         


Asn Gly Ala Gln Lys Leu Phe Gly Met Ile Ile Thr Ile Gly Gln Ala 
        115                 120                 125             


Ile Val Tyr Val Met Thr Gly Met Tyr Gly Asp Pro Ala Glu Met Gly 
    130                 135                 140                 


Ala Gly Ile Cys Leu Leu Ile Ile Ile Gln Leu Phe Val Ala Gly Leu 
145                 150                 155                 160 


Ile Val Leu Leu Leu Asp Glu Leu Leu Gln Lys Gly Tyr Gly Leu Gly 
                165                 170                 175     


Ser Gly Ile Ser Leu Phe Ile Ala Thr Asn Ile Cys Glu Thr Ile Val 
            180                 185                 190         


Trp Lys Ala Phe Ser Pro Thr Thr Ile Asn Thr Gly Arg Gly Thr Glu 
        195                 200                 205             


Phe Glu Gly Ala Val Ile Ala Leu Phe His Leu Leu Ala Thr Arg Thr 
    210                 215                 220                 


Asp Lys Val Arg Ala Leu Arg Glu Ala Phe Tyr Arg Gln Asn Leu Pro 
225                 230                 235                 240 


Asn Leu Met Asn Leu Ile Ala Thr Val Phe Val Phe Ala Val Val Ile 
                245                 250                 255     


Tyr Phe Gln Gly Phe Arg Val Asp Leu Pro Ile Lys Ser Ala Arg Tyr 
            260                 265                 270         


Arg Gly Gln Tyr Ser Ser Tyr Pro Ile Lys Leu Phe Tyr Thr Ser Asn 
        275                 280                 285             


Ile Pro Ile Ile Leu Gln Ser Ala Leu Val Ser Asn Leu Tyr Val Ile 
    290                 295                 300                 


Ser Gln Met Leu Ser Val Arg Phe Ser Gly Asn Phe Leu Val Asn Leu 
305                 310                 315                 320 


Leu Gly Gln Trp Ala Asp Val Ser Gly Gly Gly Pro Ala Arg Ser Tyr 
                325                 330                 335     


Pro Val Gly Gly Leu Cys Tyr Tyr Leu Ser Pro Pro Glu Ser Met Gly 
            340                 345                 350         


Ala Ile Phe Glu Asp Pro Val His Val Val Val Tyr Ile Ile Phe Met 
        355                 360                 365             


Leu Gly Ser Cys Ala Phe Phe Ser Lys Thr Trp Ile Glu Val Ser Gly 
    370                 375                 380                 


Ser Ser Ala Lys Asp Val Ala Lys Gln Leu Lys Glu Gln Gln Met Val 
385                 390                 395                 400 


Met Arg Gly His Arg Asp Thr Ser Met Val His Glu Leu Asn Arg Pro 
                405                 410                 415     


Lys Val Lys Leu Arg Arg Trp Lys Gly Glu Gly Arg His Phe Thr Lys 
            420                 425                 430         


Arg Ile Leu Phe Tyr 
        435         


<210>  1680
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  1680

Met Gly Ile Lys Phe Leu Glu Val Ile Lys Pro Phe Cys Ala Val Leu 
1               5                   10                  15      


Pro Glu Ile Gln Lys Pro Glu Arg Lys Ile Pro Leu Phe Gly Ile Met 
            20                  25                  30          


Ser Ser Asp Ser Ala Asp Pro Phe Tyr Trp Met Arg Val Ile Leu Ala 
        35                  40                  45              


Ser Asn Arg Gly Thr Leu Met Glu Leu Gly Ile Ser Pro Ile Val Thr 
    50                  55                  60                  


Ser Gly Leu Ile Met Gln Leu Leu Ala Gly Ala Lys Ile Ile Glu Val 
65                  70                  75                  80  


Gly Asp Thr Pro Lys Asp Arg Ala Leu Phe Asn Gly Ala Gln Lys Leu 
                85                  90                  95      


Phe Gly Met Ile Ile Thr Ile Gly Gln Ala Ile Val Tyr Val Met Thr 
            100                 105                 110         


Gly Met Tyr Gly Asp Pro Ala Glu Met Gly Ala Gly Ile Cys Leu Leu 
        115                 120                 125             


Ile Ile Ile Gln Leu Phe Val Ala Gly Leu Ile Val Leu Leu Leu Asp 
    130                 135                 140                 


Glu Leu Leu Gln Lys Gly Tyr Gly Leu Gly Ser Gly Ile Ser Leu Phe 
145                 150                 155                 160 


Ile Ala Thr Asn Ile Cys Glu Thr Ile Val Trp Lys Ala Phe Ser Pro 
                165                 170                 175     


Thr Thr Ile Asn Thr Gly Arg Gly Thr Glu Phe Glu Gly Ala Val Ile 
            180                 185                 190         


Ala Leu Phe His Leu Leu Ala Thr Arg Thr Asp Lys Val Arg Ala Leu 
        195                 200                 205             


Arg Glu Ala Phe Tyr Arg Gln Asn Leu Pro Asn Leu Met Asn Leu Ile 
    210                 215                 220                 


Ala Thr Val Phe Val Phe Ala Val Val Ile Tyr Phe Gln Gly Phe Arg 
225                 230                 235                 240 


Val Asp Leu Pro Ile Lys Ser Ala Arg Tyr Arg Gly Gln Tyr Ser Ser 
                245                 250                 255     


Tyr Pro Ile Lys Leu Phe Tyr Thr Ser Asn Ile Pro Ile Ile Leu Gln 
            260                 265                 270         


Ser Ala Leu Val Ser Asn Leu Tyr Val Ile Ser Gln Met Leu Ser Val 
        275                 280                 285             


Arg Phe Ser Gly Asn Phe Leu Val Asn Leu Leu Gly Gln Trp Ala Asp 
    290                 295                 300                 


Val Ser Gly Gly Gly Pro Ala Arg Ser Tyr Pro Val Gly Gly Leu Cys 
305                 310                 315                 320 


Tyr Tyr Leu Ser Pro Pro Glu Ser Met Gly Ala Ile Phe Glu Asp Pro 
                325                 330                 335     


Val His Val Val Val Tyr Ile Ile Phe Met Leu Gly Ser Cys Ala Phe 
            340                 345                 350         


Phe Ser Lys Thr Trp Ile Glu Val Ser Gly Ser Ser Ala Lys Asp Val 
        355                 360                 365             


Ala Lys Gln Leu Lys Glu Gln Gln Met Val Met Arg Gly His Arg Asp 
    370                 375                 380                 


Thr Ser Met Val His Glu Leu Asn Arg Tyr Ile Pro Thr Ala Ala Ala 
385                 390                 395                 400 


Phe Gly Gly Leu Cys Ile Gly Ala Leu Ser Val Leu Ala Asp Phe Leu 
                405                 410                 415     


Gly Ala Ile Gly Ser Gly Thr Gly Ile Leu Leu Ala Val Thr Ile Ile 
            420                 425                 430         


Tyr Gln Tyr Phe Glu Ile Phe Val Lys Glu Gln Ala Glu Val Gly Gly 
        435                 440                 445             


Met Gly Ala Leu Phe Phe 
    450                 


<210>  1681
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  1681

Met Gly Pro Arg Gln Gly Arg Trp Trp Leu Leu Leu Trp Leu Pro Pro 
1               5                   10                  15      


Leu Ala Thr Leu Pro Val Arg Gly Glu Ala Ala Ala Ala Ala Leu Ser 
            20                  25                  30          


Val Arg Arg Cys Lys Ala Leu Lys Glu Lys Asp Leu Ile Arg Thr Ser 
        35                  40                  45              


Glu Ser Asp Cys Tyr Cys Tyr Asn Gln Asn Ser Gln Val Glu Trp Lys 
    50                  55                  60                  


Tyr Ile Trp Ser Thr Met Gln Val Lys Ile Thr Ser Pro Gly Leu Phe 
65                  70                  75                  80  


Arg Ile Val Tyr Ile Ala Glu Arg His Asn Cys Gln Tyr Pro Glu Asn 
                85                  90                  95      


Ile Leu Ser Phe Ile Lys Cys Val Ile His Asn Phe Trp Ile Pro Lys 
            100                 105                 110         


Glu Ser Asn Glu Ile Thr Ile Ile Ile Asn Pro Tyr Arg Glu Thr Val 
        115                 120                 125             


Cys Phe Ser Val Glu Pro Val Lys Lys Ile Phe Asn Tyr Met Ile His 
    130                 135                 140                 


Val Asn Arg Asn Ile Met Asp Phe Lys Leu Phe Leu Val Phe Val Ala 
145                 150                 155                 160 


Gly Val Phe Leu Phe Phe Tyr Ala Arg Thr Leu Ser Gln Ser Pro Thr 
                165                 170                 175     


Phe Tyr Tyr Ser Ser Gly Thr Val Leu Gly Val Leu Met Thr Leu Val 
            180                 185                 190         


Phe Val Leu Leu Leu Val Lys Arg Phe Ile Pro Lys Tyr Ser Thr Phe 
        195                 200                 205             


Trp Ala Leu Met Val Gly Cys Trp Phe Ala Ser Val Tyr Ile Val Cys 
    210                 215                 220                 


Gln Leu Met Glu Asp Leu Lys Trp Leu Trp Tyr Glu Asn Arg Ile Tyr 
225                 230                 235                 240 


Val Leu Gly Tyr Val Leu Ile Val Gly Phe Phe Ser Phe Val Val Cys 
                245                 250                 255     


Tyr Lys His Gly Pro Leu Ala Asp Asp Arg Ser Arg Ser Leu Leu Met 
            260                 265                 270         


Trp Met Leu Arg Leu Leu Ser Leu Val Leu Val Tyr Ala Gly Val Ala 
        275                 280                 285             


Val Pro Gln Phe Ala Tyr Ala Ala Ile Ile Leu Leu Met Ser Ser Trp 
    290                 295                 300                 


Ser Leu His Tyr Pro Leu Arg Ala Cys Ser Tyr Met Arg Trp Lys Met 
305                 310                 315                 320 


Glu Gln Trp Phe Thr Ser Lys Glu Leu Val Val Lys Tyr Leu Thr Glu 
                325                 330                 335     


Asp Glu Tyr Arg Glu Gln Ala Asp Ala Glu Thr Asn Ser Ala Leu Glu 
            340                 345                 350         


Glu Leu Arg Arg Ala Cys Arg Lys Pro Asp Phe Pro Ser Trp Leu Val 
        355                 360                 365             


Val Ser Arg Leu His Thr Pro Ser Lys Phe Ala Asp Phe Val Leu Gly 
    370                 375                 380                 


Gly Ser His Leu Ser Pro Glu Glu Ile Ser Leu His Glu Glu Gln Tyr 
385                 390                 395                 400 


Gly Leu Gly Gly Ala Phe Leu Glu Glu Gln Leu Phe Asn Pro Ser Thr 
                405                 410                 415     


Ala 
    


<210>  1682
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  1682

Met Asp Thr Leu Glu Glu Val Thr Trp Ala Asn Gly Ser Thr Ala Leu 
1               5                   10                  15      


Pro Pro Pro Leu Ala Pro Asn Ile Ser Val Pro His Arg Cys Leu Leu 
            20                  25                  30          


Leu Leu Tyr Glu Asp Ile Gly Thr Ser Arg Val Arg Tyr Trp Asp Leu 
        35                  40                  45              


Leu Leu Leu Ile Pro Asn Val Leu Phe Leu Ile Phe Leu Leu Trp Lys 
    50                  55                  60                  


Leu Pro Ser Ala Arg Ala Lys Ile Arg Ile Thr Ser Ser Pro Ile Phe 
65                  70                  75                  80  


Ile Thr Phe Tyr Ile Leu Val Phe Val Val Ala Leu Val Gly Ile Ala 
                85                  90                  95      


Arg Ala Val Val Ser Met Thr Val Ser Thr Ser Asn Ala Ala Thr Val 
            100                 105                 110         


Ala Asp Lys Ile Leu Trp Glu Ile Thr Arg Phe Phe Leu Leu Ala Ile 
        115                 120                 125             


Glu Leu Ser Val Ile Ile Leu Gly Leu Ala Phe Gly His Leu Glu Ser 
    130                 135                 140                 


Lys Ser Ser Ile Lys Arg Val Leu Ala Ile Thr Thr Val Leu Ser Leu 
145                 150                 155                 160 


Ala Tyr Ser Val Thr Gln Gly Thr Leu Glu Ile Leu Tyr Pro Asp Ala 
                165                 170                 175     


His Leu Ser Ala Glu Asp Phe Asn Ile Tyr Gly His Gly Gly Arg Gln 
            180                 185                 190         


Phe Trp Leu Val Ser Ser Cys Phe Phe Phe Leu Leu Cys Arg Cys His 
        195                 200                 205             


Asn Leu Pro Val Leu Gln Leu Leu Arg Ser Ala His Leu Arg Gly Phe 
    210                 215                 220                 


Pro Pro Gly Leu Leu Arg Leu Gly Ala Gln Asp Pro Leu Leu Leu Gln 
225                 230                 235                 240 


Met Pro Ser Gly Arg Asp Arg Gly Ala Arg Cys Thr Pro Thr Pro Ala 
                245                 250                 255     


Leu Arg Cys Gly Pro Ala Gly Gly Pro Gly Gly Cys Arg Gly Cys Trp 
            260                 265                 270         


Gly Leu Ser Cys Gln Leu Leu Glu His Ala Val Arg Leu Cys Arg Arg 
        275                 280                 285             


Gly Gly Leu Pro Gly 
    290             


<210>  1683
<211>  912
<212>  PRT
<213>  Homo sapiens

<400>  1683

Met Gly Asp Pro Asp Leu Leu Glu Val Leu Ala Glu Glu Gly Glu Lys 
1               5                   10                  15      


Val Asn Lys His Ile Asp Tyr Ser Phe Gln Met Ser Glu Ser Leu Ser 
            20                  25                  30          


Ser Arg Glu Thr Ser Phe Leu Ile Asn Glu Glu Thr Met Pro Ala Lys 
        35                  40                  45              


Arg Phe Asn Leu Phe Leu Arg Arg Arg Leu Met Phe Gln Lys Asn Gln 
    50                  55                  60                  


Gln Ser Lys Asp Ser Ile Phe Phe Arg Asp Gly Ile Arg Gln Ile Asp 
65                  70                  75                  80  


Phe Val Leu Ser Tyr Val Asp Asp Val Lys Lys Asp Ala Glu Leu Lys 
                85                  90                  95      


Ala Glu Arg Arg Lys Glu Phe Glu Thr Asn Leu Arg Lys Thr Gly Leu 
            100                 105                 110         


Glu Leu Glu Ile Glu Asp Lys Arg Asp Ser Glu Asp Gly Arg Thr Tyr 
        115                 120                 125             


Phe Val Lys Ile His Ala Pro Trp Glu Val Leu Val Thr Tyr Ala Glu 
    130                 135                 140                 


Val Leu Gly Ile Lys Met Pro Ile Lys Glu Ser Asp Ile Pro Arg Pro 
145                 150                 155                 160 


Lys His Thr Pro Ile Ser Tyr Val Leu Gly Pro Val Arg Leu Pro Leu 
                165                 170                 175     


Ser Val Lys Tyr Pro His Pro Glu Tyr Phe Thr Ala Gln Phe Ser Arg 
            180                 185                 190         


His Arg Gln Glu Leu Phe Leu Ile Glu Asp Gln Ala Thr Phe Phe Pro 
        195                 200                 205             


Ser Ser Ser Arg Asn Arg Ile Val Tyr Tyr Ile Leu Ser Arg Cys Pro 
    210                 215                 220                 


Phe Gly Ile Glu Asp Gly Lys Lys Arg Phe Gly Ile Glu Arg Leu Leu 
225                 230                 235                 240 


Asn Ser Asn Thr Tyr Ser Ser Ala Tyr Pro Leu His Asp Gly Gln Tyr 
                245                 250                 255     


Trp Lys Pro Ser Glu Pro Pro Asn Pro Thr Asn Glu Arg Tyr Thr Leu 
            260                 265                 270         


His Gln Asn Trp Ala Arg Phe Ser Tyr Phe Tyr Lys Glu Gln Pro Leu 
        275                 280                 285             


Asp Leu Ile Lys Asn Tyr Tyr Gly Glu Lys Ile Gly Ile Tyr Phe Val 
    290                 295                 300                 


Phe Leu Gly Phe Tyr Thr Glu Met Leu Phe Phe Ala Ala Val Val Gly 
305                 310                 315                 320 


Leu Ala Cys Phe Ile Tyr Gly Leu Leu Ser Met Glu His Asn Thr Ser 
                325                 330                 335     


Ser Thr Glu Ile Cys Asp Pro Glu Ile Gly Gly Gln Met Ile Met Cys 
            340                 345                 350         


Pro Leu Cys Asp Gln Val Cys Asp Tyr Trp Arg Leu Asn Ser Thr Cys 
        355                 360                 365             


Leu Ala Ser Lys Phe Ser His Leu Phe Asp Asn Glu Ser Thr Val Phe 
    370                 375                 380                 


Phe Ala Ile Phe Met Gly Ile Trp Val Thr Leu Phe Leu Glu Phe Trp 
385                 390                 395                 400 


Lys Gln Arg Gln Ala Arg Leu Glu Tyr Glu Trp Asp Leu Val Asp Phe 
                405                 410                 415     


Glu Glu Glu Gln Gln Gln Leu Gln Leu Arg Pro Glu Phe Glu Ala Met 
            420                 425                 430         


Cys Lys His Arg Lys Leu Asn Ala Val Thr Lys Glu Met Glu Pro Tyr 
        435                 440                 445             


Met Pro Leu Tyr Thr Arg Ile Pro Trp Tyr Phe Leu Ser Gly Ala Thr 
    450                 455                 460                 


Val Thr Leu Trp Met Ser Leu Val Val Thr Ser Met Val Ala Val Ile 
465                 470                 475                 480 


Val Tyr Arg Leu Ser Val Phe Ala Thr Phe Ala Ser Phe Met Glu Ser 
                485                 490                 495     


Asp Ala Ser Leu Lys Gln Val Lys Ser Phe Leu Thr Pro Gln Ile Thr 
            500                 505                 510         


Thr Ser Leu Thr Gly Ser Cys Leu Asn Phe Ile Val Ile Leu Ile Leu 
        515                 520                 525             


Asn Phe Phe Tyr Glu Lys Ile Ser Ala Trp Ile Thr Lys Met Glu Ile 
    530                 535                 540                 


Pro Arg Thr Tyr Gln Glu Tyr Glu Ser Ser Leu Thr Leu Lys Met Phe 
545                 550                 555                 560 


Leu Phe Gln Phe Val Asn Phe Tyr Ser Ser Cys Phe Tyr Val Ala Phe 
                565                 570                 575     


Phe Lys Gly Lys Phe Val Gly Tyr Pro Gly Lys Tyr Thr Tyr Leu Phe 
            580                 585                 590         


Asn Glu Trp Arg Ser Glu Glu Cys Asp Pro Gly Gly Cys Leu Ile Glu 
        595                 600                 605             


Leu Thr Thr Gln Leu Thr Ile Ile Met Thr Gly Lys Gln Ile Phe Gly 
    610                 615                 620                 


Asn Ile Lys Glu Ala Ile Tyr Pro Leu Ala Leu Asn Trp Trp Arg Arg 
625                 630                 635                 640 


Arg Lys Ala Arg Thr Asn Ser Glu Lys Leu Tyr Ser Arg Trp Glu Gln 
                645                 650                 655     


Asp His Asp Leu Glu Ser Phe Gly Pro Leu Gly Leu Phe Tyr Glu Tyr 
            660                 665                 670         


Leu Glu Thr Val Thr Gln Phe Gly Phe Val Thr Leu Phe Val Ala Ser 
        675                 680                 685             


Phe Pro Leu Ala Pro Leu Leu Ala Leu Ile Asn Asn Ile Val Glu Ile 
    690                 695                 700                 


Arg Val Asp Ala Trp Lys Leu Thr Thr Gln Tyr Arg Arg Thr Val Ala 
705                 710                 715                 720 


Ser Lys Ala His Ser Ile Gly Val Trp Gln Asp Ile Leu Tyr Gly Met 
                725                 730                 735     


Ala Val Leu Ser Val Ala Thr Asn Ala Phe Ile Val Ala Phe Thr Ser 
            740                 745                 750         


Asp Ile Ile Pro Arg Leu Val Tyr Tyr Tyr Ala Tyr Ser Thr Asn Ala 
        755                 760                 765             


Thr Gln Pro Met Thr Gly Tyr Val Asn Asn Ser Leu Ser Val Phe Leu 
    770                 775                 780                 


Ile Ala Asp Phe Pro Asn His Thr Ala Pro Ser Glu Lys Arg Asp Phe 
785                 790                 795                 800 


Ile Thr Cys Arg Tyr Arg Asp Tyr Arg Tyr Pro Pro Asp Asp Glu Asn 
                805                 810                 815     


Lys Tyr Phe His Asn Met Gln Phe Trp His Val Leu Ala Ala Lys Met 
            820                 825                 830         


Thr Phe Ile Ile Val Met Glu His Val Val Phe Leu Val Lys Phe Leu 
        835                 840                 845             


Leu Ala Trp Met Ile Pro Asp Val Pro Lys Asp Val Val Glu Arg Ile 
    850                 855                 860                 


Lys Arg Glu Lys Leu Met Thr Ile Lys Ile Leu His Asp Phe Glu Leu 
865                 870                 875                 880 


Asn Lys Leu Lys Glu Asn Leu Gly Ile Asn Ser Asn Glu Phe Ala Lys 
                885                 890                 895     


His Val Met Ile Glu Glu Asn Lys Ala Gln Leu Ala Lys Ser Thr Leu 
            900                 905                 910         


<210>  1684
<211>  892
<212>  PRT
<213>  Homo sapiens

<400>  1684

Met Phe Cys Ala Ala Val Leu Glu Asn Leu Gly Gln Thr Ile Val Pro 
1               5                   10                  15      


Asp Leu Gly Ser Leu Glu Ser Gln His Asp Phe Arg Thr Pro Glu Phe 
            20                  25                  30          


Glu Glu Phe Asn Gly Lys Pro Asp Ser Leu Phe Phe Asn Asp Gly Gln 
        35                  40                  45              


Arg Arg Ile Asp Phe Val Leu Val Tyr Glu Asp Glu Ser Arg Lys Glu 
    50                  55                  60                  


Thr Asn Lys Lys Gly Thr Asn Glu Lys Gln Arg Arg Lys Arg Gln Ala 
65                  70                  75                  80  


Tyr Glu Ser Asn Leu Ile Cys His Gly Leu Gln Leu Glu Ala Thr Arg 
                85                  90                  95      


Ser Val Leu Asp Asp Lys Leu Val Phe Val Lys Val His Ala Pro Trp 
            100                 105                 110         


Glu Val Leu Cys Thr Tyr Ala Glu Ile Met His Ile Lys Leu Pro Leu 
        115                 120                 125             


Lys Pro Asn Asp Leu Lys Asn Arg Ser Ser Ala Phe Gly Thr Leu Asn 
    130                 135                 140                 


Trp Phe Thr Lys Val Leu Ser Val Asp Glu Ser Ile Ile Lys Pro Glu 
145                 150                 155                 160 


Gln Glu Phe Phe Thr Ala Pro Phe Glu Lys Asn Arg Met Asn Asp Phe 
                165                 170                 175     


Tyr Ile Val Asp Arg Asp Ala Phe Phe Asn Pro Ala Thr Arg Ser Arg 
            180                 185                 190         


Ile Val Tyr Phe Ile Leu Ser Arg Val Lys Tyr Gln Val Ile Asn Asn 
        195                 200                 205             


Val Ser Lys Phe Gly Ile Asn Arg Leu Val Asn Ser Gly Ile Tyr Lys 
    210                 215                 220                 


Ala Ala Phe Pro Leu His Asp Cys Lys Phe Arg Arg Gln Ser Glu Asp 
225                 230                 235                 240 


Pro Ser Cys Pro Asn Glu Arg Tyr Leu Leu Tyr Arg Glu Trp Ala His 
                245                 250                 255     


Pro Arg Ser Ile Tyr Lys Lys Gln Pro Leu Asp Leu Ile Arg Lys Tyr 
            260                 265                 270         


Tyr Gly Glu Lys Ile Gly Ile Tyr Phe Ala Trp Leu Gly Tyr Tyr Thr 
        275                 280                 285             


Gln Met Leu Leu Leu Ala Ala Val Val Gly Val Ala Cys Phe Leu Tyr 
    290                 295                 300                 


Gly Tyr Leu Asn Gln Asp Asn Cys Thr Trp Ser Lys Glu Val Cys His 
305                 310                 315                 320 


Pro Asp Ile Gly Gly Lys Ile Ile Met Cys Pro Gln Cys Asp Arg Leu 
                325                 330                 335     


Cys Pro Phe Trp Lys Leu Asn Ile Thr Cys Glu Ser Ser Lys Lys Leu 
            340                 345                 350         


Cys Ile Phe Asp Ser Phe Gly Thr Leu Val Phe Ala Val Phe Met Gly 
        355                 360                 365             


Val Trp Val Thr Leu Phe Leu Glu Phe Trp Lys Arg Arg Gln Ala Glu 
    370                 375                 380                 


Leu Glu Tyr Glu Trp Asp Thr Val Glu Leu Gln Gln Glu Glu Gln Ala 
385                 390                 395                 400 


Arg Pro Glu Tyr Glu Ala Arg Cys Thr His Val Val Ile Asn Glu Ile 
                405                 410                 415     


Thr Gln Glu Glu Glu Arg Ile Pro Phe Thr Ala Trp Gly Lys Cys Ile 
            420                 425                 430         


Arg Ile Thr Leu Cys Ala Ser Ala Val Phe Phe Trp Ile Leu Leu Ile 
        435                 440                 445             


Ile Ala Ser Val Ile Gly Ile Ile Val Tyr Arg Leu Ser Val Phe Ile 
    450                 455                 460                 


Val Phe Ser Ala Lys Leu Pro Lys Asn Ile Asn Gly Thr Asp Pro Ile 
465                 470                 475                 480 


Gln Lys Tyr Leu Thr Pro Gln Thr Ala Thr Ser Ile Thr Ala Ser Ile 
                485                 490                 495     


Ile Ser Phe Ile Ile Ile Met Ile Leu Asn Thr Ile Tyr Glu Lys Val 
            500                 505                 510         


Ala Ile Met Ile Thr Asn Phe Glu Leu Pro Arg Thr Gln Thr Asp Tyr 
        515                 520                 525             


Glu Asn Ser Leu Thr Met Lys Met Phe Leu Phe Gln Phe Val Asn Tyr 
    530                 535                 540                 


Tyr Ser Ser Cys Phe Tyr Ile Ala Phe Phe Lys Gly Lys Phe Val Gly 
545                 550                 555                 560 


Tyr Pro Gly Asp Pro Val Tyr Trp Leu Gly Lys Tyr Arg Asn Glu Glu 
                565                 570                 575     


Cys Asp Pro Gly Gly Cys Leu Leu Glu Leu Thr Thr Gln Leu Thr Ile 
            580                 585                 590         


Ile Met Gly Gly Lys Ala Ile Trp Asn Asn Ile Gln Glu Val Leu Leu 
        595                 600                 605             


Pro Trp Ile Met Asn Leu Ile Gly Arg Phe His Arg Val Ser Gly Ser 
    610                 615                 620                 


Glu Lys Ile Thr Pro Arg Trp Glu Gln Asp Tyr His Leu Gln Pro Met 
625                 630                 635                 640 


Gly Lys Leu Gly Leu Phe Tyr Glu Tyr Leu Glu Met Ile Ile Gln Phe 
                645                 650                 655     


Gly Phe Val Thr Leu Phe Val Ala Ser Phe Pro Leu Ala Pro Leu Leu 
            660                 665                 670         


Ala Leu Val Asn Asn Ile Leu Glu Ile Arg Val Asp Ala Trp Lys Leu 
        675                 680                 685             


Thr Thr Gln Phe Arg Arg Leu Val Pro Glu Lys Ala Gln Asp Ile Gly 
    690                 695                 700                 


Ala Trp Gln Pro Ile Met Gln Gly Ile Ala Ile Leu Ala Val Val Thr 
705                 710                 715                 720 


Asn Ala Met Ile Ile Ala Phe Thr Ser Asp Met Ile Pro Arg Leu Val 
                725                 730                 735     


Tyr Tyr Trp Ser Phe Ser Val Pro Pro Tyr Gly Asp His Thr Ser Tyr 
            740                 745                 750         


Thr Met Glu Gly Tyr Ile Asn Asn Thr Leu Ser Ile Phe Lys Val Ala 
        755                 760                 765             


Asp Phe Lys Asn Lys Ser Lys Gly Asn Pro Tyr Ser Asp Leu Gly Asn 
    770                 775                 780                 


His Thr Thr Cys Arg Tyr Arg Asp Phe Arg Tyr Pro Pro Gly His Pro 
785                 790                 795                 800 


Gln Glu Tyr Lys His Asn Ile Tyr Tyr Trp His Val Ile Ala Ala Lys 
                805                 810                 815     


Leu Ala Phe Ile Ile Val Met Glu His Val Ile Tyr Ser Val Lys Phe 
            820                 825                 830         


Phe Ile Ser Tyr Ala Ile Pro Asp Val Ser Lys Arg Thr Lys Ser Lys 
        835                 840                 845             


Ile Gln Arg Glu Lys Tyr Leu Thr Gln Lys Leu Leu His Glu Asn His 
    850                 855                 860                 


Leu Lys Asp Met Thr Lys Asn Met Gly Val Ile Ala Glu Arg Met Ile 
865                 870                 875                 880 


Glu Ala Val Asp Asn Asn Leu Arg Pro Lys Ser Glu 
                885                 890         


<210>  1685
<211>  929
<212>  PRT
<213>  Homo sapiens

<400>  1685

Met Lys Lys Met Ser Arg Asn Val Leu Leu Gln Met Glu Glu Glu Glu 
1               5                   10                  15      


Asp Asp Asp Asp Gly Asp Ile Val Leu Glu Asn Leu Gly Gln Thr Ile 
            20                  25                  30          


Val Pro Asp Leu Gly Ser Leu Glu Ser Gln His Asp Phe Arg Thr Pro 
        35                  40                  45              


Glu Phe Glu Glu Phe Asn Gly Lys Pro Asp Ser Leu Phe Phe Asn Asp 
    50                  55                  60                  


Gly Gln Arg Arg Ile Asp Phe Val Leu Val Tyr Glu Asp Glu Ser Arg 
65                  70                  75                  80  


Lys Glu Thr Asn Lys Lys Gly Thr Asn Glu Lys Gln Arg Arg Lys Arg 
                85                  90                  95      


Gln Ala Tyr Glu Ser Asn Leu Ile Cys His Gly Leu Gln Leu Glu Ala 
            100                 105                 110         


Thr Arg Ser Val Leu Asp Asp Lys Leu Val Phe Val Lys Val His Ala 
        115                 120                 125             


Pro Trp Glu Val Leu Cys Thr Tyr Ala Glu Ile Met His Ile Lys Leu 
    130                 135                 140                 


Pro Leu Lys Pro Asn Asp Leu Lys Asn Arg Ser Ser Ala Phe Gly Thr 
145                 150                 155                 160 


Leu Asn Trp Phe Thr Lys Val Leu Ser Val Asp Glu Ser Ile Ile Lys 
                165                 170                 175     


Pro Glu Gln Glu Phe Phe Thr Ala Pro Phe Glu Lys Asn Arg Met Asn 
            180                 185                 190         


Asp Phe Tyr Ile Val Asp Arg Asp Ala Phe Phe Asn Pro Ala Thr Arg 
        195                 200                 205             


Ser Arg Ile Val Tyr Phe Ile Leu Ser Arg Val Lys Tyr Gln Val Ile 
    210                 215                 220                 


Asn Asn Val Ser Lys Phe Gly Ile Asn Arg Leu Val Asn Ser Gly Ile 
225                 230                 235                 240 


Tyr Lys Ala Ala Phe Pro Leu His Asp Cys Lys Phe Arg Arg Gln Ser 
                245                 250                 255     


Glu Asp Pro Ser Cys Pro Asn Glu Arg Tyr Leu Leu Tyr Arg Glu Trp 
            260                 265                 270         


Ala His Pro Arg Ser Ile Tyr Lys Lys Gln Pro Leu Asp Leu Ile Arg 
        275                 280                 285             


Lys Tyr Tyr Gly Glu Lys Ile Gly Ile Tyr Phe Ala Trp Leu Gly Tyr 
    290                 295                 300                 


Tyr Thr Gln Met Leu Leu Leu Ala Ala Val Val Gly Val Ala Cys Phe 
305                 310                 315                 320 


Leu Tyr Gly Tyr Leu Asn Gln Asp Asn Cys Thr Trp Ser Lys Glu Val 
                325                 330                 335     


Cys His Pro Asp Ile Gly Gly Lys Ile Ile Met Cys Pro Gln Cys Asp 
            340                 345                 350         


Arg Leu Cys Pro Phe Trp Lys Leu Asn Ile Thr Cys Glu Ser Ser Lys 
        355                 360                 365             


Lys Leu Cys Ile Phe Asp Ser Phe Gly Thr Leu Val Phe Ala Val Phe 
    370                 375                 380                 


Met Gly Val Trp Val Thr Leu Phe Leu Glu Phe Trp Lys Arg Arg Gln 
385                 390                 395                 400 


Ala Glu Leu Glu Tyr Glu Trp Asp Thr Val Glu Leu Gln Gln Glu Glu 
                405                 410                 415     


Gln Ala Arg Pro Glu Tyr Glu Ala Arg Cys Thr His Val Val Ile Asn 
            420                 425                 430         


Glu Ile Thr Gln Glu Glu Glu Arg Ile Pro Phe Thr Ala Trp Gly Lys 
        435                 440                 445             


Cys Ile Arg Ile Thr Leu Cys Ala Ser Ala Val Phe Phe Trp Ile Leu 
    450                 455                 460                 


Leu Ile Ile Ala Ser Val Ile Gly Ile Ile Val Tyr Arg Leu Ser Val 
465                 470                 475                 480 


Phe Ile Val Phe Ser Ala Lys Leu Pro Lys Asn Ile Asn Gly Thr Asp 
                485                 490                 495     


Pro Ile Gln Lys Tyr Leu Thr Pro Gln Thr Ala Thr Ser Ile Thr Ala 
            500                 505                 510         


Ser Ile Ile Ser Phe Ile Ile Ile Met Ile Leu Asn Thr Ile Tyr Glu 
        515                 520                 525             


Lys Val Ala Ile Met Ile Thr Asn Phe Glu Leu Pro Arg Thr Gln Thr 
    530                 535                 540                 


Asp Tyr Glu Asn Ser Leu Thr Met Lys Met Phe Leu Phe Gln Phe Val 
545                 550                 555                 560 


Asn Tyr Tyr Ser Ser Cys Phe Tyr Ile Ala Phe Phe Lys Gly Lys Phe 
                565                 570                 575     


Val Gly Tyr Pro Gly Asp Pro Val Tyr Trp Leu Gly Lys Tyr Arg Asn 
            580                 585                 590         


Glu Glu Cys Asp Pro Gly Gly Cys Leu Leu Glu Leu Thr Thr Gln Leu 
        595                 600                 605             


Thr Ile Ile Met Gly Gly Lys Ala Ile Trp Asn Asn Ile Gln Glu Val 
    610                 615                 620                 


Leu Leu Pro Trp Ile Met Asn Leu Ile Gly Arg Phe His Arg Val Ser 
625                 630                 635                 640 


Gly Ser Glu Lys Ile Thr Pro Arg Trp Glu Gln Asp Tyr His Leu Gln 
                645                 650                 655     


Pro Met Gly Lys Leu Gly Leu Phe Tyr Glu Tyr Leu Glu Met Ile Ile 
            660                 665                 670         


Gln Phe Gly Phe Val Thr Leu Phe Val Ala Ser Phe Pro Leu Ala Pro 
        675                 680                 685             


Leu Leu Ala Leu Val Asn Asn Ile Leu Glu Ile Arg Val Asp Ala Trp 
    690                 695                 700                 


Lys Leu Thr Thr Gln Phe Arg Arg Leu Val Pro Glu Lys Ala Gln Asp 
705                 710                 715                 720 


Ile Gly Ala Trp Gln Pro Ile Met Gln Gly Ile Ala Ile Leu Ala Val 
                725                 730                 735     


Val Thr Asn Ala Met Ile Ile Ala Phe Thr Ser Asp Met Ile Pro Arg 
            740                 745                 750         


Leu Val Tyr Tyr Trp Ser Phe Ser Val Pro Pro Tyr Gly Asp His Thr 
        755                 760                 765             


Ser Tyr Thr Met Glu Gly Tyr Ile Asn Asn Thr Leu Ser Ile Phe Lys 
    770                 775                 780                 


Val Ala Asp Phe Lys Asn Lys Ser Lys Gly Asn Pro Tyr Ser Asp Leu 
785                 790                 795                 800 


Gly Asn His Thr Thr Cys Arg Tyr Arg Asp Phe Arg Tyr Pro Pro Gly 
                805                 810                 815     


His Pro Gln Glu Tyr Lys His Asn Ile Tyr Tyr Trp His Val Ile Ala 
            820                 825                 830         


Ala Lys Leu Ala Phe Ile Ile Val Met Glu Tyr Leu Ala Leu Leu Pro 
        835                 840                 845             


Arg Leu Gly His Ser Gly Met Ile Leu Ala His Cys Asn Leu Arg Leu 
    850                 855                 860                 


Pro Val Asp Cys Cys Met Cys Tyr Arg Phe Val Asp Glu Ile Arg Leu 
865                 870                 875                 880 


Leu Glu Gln Leu Thr Ser Asp Phe Ile Asp Ser Leu Tyr Tyr Ile Phe 
                885                 890                 895     


Ser Ile Ser Ile Ile Ser Ile Phe Phe Ser Val Thr Phe Phe Phe Leu 
            900                 905                 910         


Leu Leu Ser Leu Gly Pro Thr Pro Cys Phe Ser Val Ser Asn Phe Leu 
        915                 920                 925             


Ser 
    


<210>  1686
<211>  910
<212>  PRT
<213>  Homo sapiens

<400>  1686

Met Lys Lys Met Ser Arg Asn Val Leu Leu Gln Met Glu Glu Glu Glu 
1               5                   10                  15      


Asp Asp Asp Asp Gly Asp Ile Val Leu Glu Asn Leu Gly Gln Thr Ile 
            20                  25                  30          


Val Pro Asp Leu Gly Ser Leu Glu Ser Gln His Asp Phe Arg Thr Pro 
        35                  40                  45              


Glu Phe Glu Glu Phe Asn Gly Lys Pro Asp Ser Leu Phe Phe Asn Asp 
    50                  55                  60                  


Gly Gln Arg Arg Ile Asp Phe Val Leu Val Tyr Glu Asp Glu Ser Arg 
65                  70                  75                  80  


Lys Glu Thr Asn Lys Lys Gly Thr Asn Glu Lys Gln Arg Arg Lys Arg 
                85                  90                  95      


Gln Ala Tyr Glu Ser Asn Leu Ile Cys His Gly Leu Gln Leu Glu Ala 
            100                 105                 110         


Thr Arg Ser Val Leu Asp Asp Lys Leu Val Phe Val Lys Val His Ala 
        115                 120                 125             


Pro Trp Glu Val Leu Cys Thr Tyr Ala Glu Ile Met His Ile Lys Leu 
    130                 135                 140                 


Pro Leu Lys Pro Asn Asp Leu Lys Asn Arg Ser Ser Ala Phe Gly Thr 
145                 150                 155                 160 


Leu Asn Trp Phe Thr Lys Val Leu Ser Val Asp Glu Ser Ile Ile Lys 
                165                 170                 175     


Pro Glu Gln Glu Phe Phe Thr Ala Pro Phe Glu Lys Asn Arg Met Asn 
            180                 185                 190         


Asp Phe Tyr Ile Val Asp Arg Asp Ala Phe Phe Asn Pro Ala Thr Arg 
        195                 200                 205             


Ser Arg Ile Val Tyr Phe Ile Leu Ser Arg Val Lys Tyr Gln Val Ile 
    210                 215                 220                 


Asn Asn Val Ser Lys Phe Gly Ile Asn Arg Leu Val Asn Ser Gly Ile 
225                 230                 235                 240 


Tyr Lys Ala Ala Phe Pro Leu His Asp Cys Lys Phe Arg Arg Gln Ser 
                245                 250                 255     


Glu Asp Pro Ser Cys Pro Asn Glu Arg Tyr Leu Leu Tyr Arg Glu Trp 
            260                 265                 270         


Ala His Pro Arg Ser Ile Tyr Lys Lys Gln Pro Leu Asp Leu Ile Arg 
        275                 280                 285             


Lys Tyr Tyr Gly Glu Lys Ile Gly Ile Tyr Phe Ala Trp Leu Gly Tyr 
    290                 295                 300                 


Tyr Thr Gln Met Leu Leu Leu Ala Ala Val Val Gly Val Ala Cys Phe 
305                 310                 315                 320 


Leu Tyr Gly Tyr Leu Asn Gln Asp Asn Cys Thr Trp Ser Lys Glu Val 
                325                 330                 335     


Cys His Pro Asp Ile Gly Gly Lys Ile Ile Met Cys Pro Gln Cys Asp 
            340                 345                 350         


Arg Leu Cys Pro Phe Trp Lys Leu Asn Ile Thr Cys Glu Ser Ser Lys 
        355                 360                 365             


Lys Leu Cys Ile Phe Asp Ser Phe Gly Thr Leu Val Phe Ala Val Phe 
    370                 375                 380                 


Met Gly Val Trp Val Thr Leu Phe Leu Glu Phe Trp Lys Arg Arg Gln 
385                 390                 395                 400 


Ala Glu Leu Glu Tyr Glu Trp Asp Thr Val Glu Leu Gln Gln Glu Glu 
                405                 410                 415     


Gln Ala Arg Pro Glu Tyr Glu Ala Arg Cys Thr His Val Val Ile Asn 
            420                 425                 430         


Glu Ile Thr Gln Glu Glu Glu Arg Ile Pro Phe Thr Ala Trp Gly Lys 
        435                 440                 445             


Cys Ile Arg Ile Thr Leu Cys Ala Ser Ala Val Phe Phe Trp Ile Leu 
    450                 455                 460                 


Leu Ile Ile Ala Ser Val Ile Gly Ile Ile Val Tyr Arg Leu Ser Val 
465                 470                 475                 480 


Phe Ile Val Phe Ser Ala Lys Leu Pro Lys Asn Ile Asn Gly Thr Asp 
                485                 490                 495     


Pro Ile Gln Lys Tyr Leu Thr Pro Gln Thr Ala Thr Ser Ile Thr Ala 
            500                 505                 510         


Ser Ile Ile Ser Phe Ile Ile Ile Met Ile Leu Asn Thr Ile Tyr Glu 
        515                 520                 525             


Lys Val Ala Ile Met Ile Thr Asn Phe Glu Leu Pro Arg Thr Gln Thr 
    530                 535                 540                 


Asp Tyr Glu Asn Ser Leu Thr Met Lys Met Phe Leu Phe Gln Phe Val 
545                 550                 555                 560 


Asn Tyr Tyr Ser Ser Cys Phe Tyr Ile Ala Phe Phe Lys Gly Lys Phe 
                565                 570                 575     


Val Gly Tyr Pro Gly Asp Pro Val Tyr Trp Leu Gly Lys Tyr Arg Asn 
            580                 585                 590         


Glu Glu Cys Asp Pro Gly Gly Cys Leu Leu Glu Leu Thr Thr Gln Leu 
        595                 600                 605             


Thr Ile Ile Met Gly Gly Lys Ala Ile Trp Asn Asn Ile Gln Glu Val 
    610                 615                 620                 


Leu Leu Pro Trp Ile Met Asn Leu Ile Gly Arg Phe His Arg Val Ser 
625                 630                 635                 640 


Gly Ser Glu Lys Ile Thr Pro Arg Trp Glu Gln Asp Tyr His Leu Gln 
                645                 650                 655     


Pro Met Gly Lys Leu Gly Leu Phe Tyr Glu Tyr Leu Glu Met Ile Ile 
            660                 665                 670         


Gln Phe Gly Phe Val Thr Leu Phe Val Ala Ser Phe Pro Leu Ala Pro 
        675                 680                 685             


Leu Leu Ala Leu Val Asn Asn Ile Leu Glu Ile Arg Val Asp Ala Trp 
    690                 695                 700                 


Lys Leu Thr Thr Gln Phe Arg Arg Leu Val Pro Glu Lys Ala Gln Asp 
705                 710                 715                 720 


Ile Gly Ala Trp Gln Pro Ile Met Gln Gly Ile Ala Ile Leu Ala Val 
                725                 730                 735     


Val Thr Asn Ala Met Ile Ile Ala Phe Thr Ser Asp Met Ile Pro Arg 
            740                 745                 750         


Leu Val Tyr Tyr Trp Ser Phe Ser Val Pro Pro Tyr Gly Asp His Thr 
        755                 760                 765             


Ser Tyr Thr Met Glu Gly Tyr Ile Asn Asn Thr Leu Ser Ile Phe Lys 
    770                 775                 780                 


Val Ala Asp Phe Lys Asn Lys Ser Lys Gly Asn Pro Tyr Ser Asp Leu 
785                 790                 795                 800 


Gly Asn His Thr Thr Cys Arg Tyr Arg Asp Phe Arg Tyr Pro Pro Gly 
                805                 810                 815     


His Pro Gln Glu Tyr Lys His Asn Ile Tyr Tyr Trp His Val Ile Ala 
            820                 825                 830         


Ala Lys Leu Ala Phe Ile Ile Val Met Glu His Val Ile Tyr Ser Val 
        835                 840                 845             


Lys Phe Phe Ile Ser Tyr Ala Ile Pro Asp Val Ser Lys Arg Thr Lys 
    850                 855                 860                 


Ser Lys Ile Gln Arg Glu Lys Tyr Leu Thr Gln Lys Leu Leu His Glu 
865                 870                 875                 880 


Asn His Leu Lys Asp Met Thr Lys Asn Met Gly Val Ile Ala Glu Arg 
                885                 890                 895     


Met Ile Glu Ala Val Asp Asn Asn Leu Arg Pro Lys Ser Glu 
            900                 905                 910 


<210>  1687
<211>  1029
<212>  PRT
<213>  Homo sapiens

<400>  1687

Met Leu Phe Arg Ala Arg Gly Pro Val Arg Gly Arg Gly Trp Gly Arg 
1               5                   10                  15      


Pro Ala Glu Ala Pro Arg Arg Gly Arg Ser Pro Pro Trp Ser Pro Ala 
            20                  25                  30          


Trp Ile Cys Cys Trp Ala Leu Ala Gly Cys Gln Ala Ala Trp Ala Gly 
        35                  40                  45              


Asp Leu Pro Ser Ser Ser Ser Arg Pro Leu Pro Pro Cys Gln Glu Lys 
    50                  55                  60                  


Asp Tyr His Phe Glu Tyr Thr Glu Cys Asp Ser Ser Gly Ser Arg Trp 
65                  70                  75                  80  


Arg Val Ala Ile Pro Asn Ser Ala Val Asp Cys Ser Gly Leu Pro Asp 
                85                  90                  95      


Pro Val Arg Gly Lys Glu Cys Thr Phe Ser Cys Ala Ser Gly Glu Tyr 
            100                 105                 110         


Leu Glu Met Lys Asn Gln Val Cys Ser Lys Cys Gly Glu Gly Thr Tyr 
        115                 120                 125             


Ser Leu Gly Ser Gly Ile Lys Phe Asp Glu Trp Asp Glu Leu Pro Ala 
    130                 135                 140                 


Gly Phe Ser Asn Ile Ala Thr Phe Met Asp Thr Val Val Gly Pro Ser 
145                 150                 155                 160 


Asp Ser Arg Pro Asp Gly Cys Asn Asn Ser Ser Trp Ile Pro Arg Gly 
                165                 170                 175     


Asn Tyr Ile Glu Ser Asn Arg Asp Asp Cys Thr Val Ser Leu Ile Tyr 
            180                 185                 190         


Ala Val His Leu Lys Lys Ser Gly Tyr Val Phe Phe Glu Tyr Gln Tyr 
        195                 200                 205             


Val Asp Asn Asn Ile Phe Phe Glu Phe Phe Ile Gln Asn Asp Gln Cys 
    210                 215                 220                 


Gln Glu Met Asp Thr Thr Thr Asp Lys Trp Val Lys Leu Thr Asp Asn 
225                 230                 235                 240 


Gly Glu Trp Gly Ser His Ser Val Met Leu Lys Ser Gly Thr Asn Ile 
                245                 250                 255     


Leu Tyr Trp Arg Thr Thr Gly Ile Leu Met Gly Ser Lys Ala Val Lys 
            260                 265                 270         


Pro Val Leu Val Lys Asn Ile Thr Ile Glu Gly Val Ala Tyr Thr Ser 
        275                 280                 285             


Glu Cys Phe Pro Cys Lys Pro Gly Thr Phe Ser Asn Lys Pro Gly Ser 
    290                 295                 300                 


Phe Asn Cys Gln Val Cys Pro Arg Asn Thr Tyr Ser Glu Lys Gly Ala 
305                 310                 315                 320 


Lys Glu Cys Ile Arg Cys Lys Asp Asp Ser Gln Phe Ser Glu Glu Gly 
                325                 330                 335     


Ser Ser Glu Cys Thr Glu Arg Pro Pro Cys Thr Thr Lys Asp Tyr Phe 
            340                 345                 350         


Gln Ile His Thr Pro Cys Asp Glu Glu Gly Lys Thr Gln Ile Met Tyr 
        355                 360                 365             


Lys Trp Ile Glu Pro Lys Ile Cys Arg Glu Asp Leu Thr Asp Ala Ile 
    370                 375                 380                 


Arg Leu Pro Pro Ser Gly Glu Lys Lys Asp Cys Pro Pro Cys Asn Pro 
385                 390                 395                 400 


Gly Phe Tyr Asn Asn Gly Ser Ser Ser Cys His Pro Cys Pro Pro Gly 
                405                 410                 415     


Thr Phe Ser Asp Gly Thr Lys Glu Cys Arg Pro Cys Pro Ala Gly Thr 
            420                 425                 430         


Glu Pro Ala Leu Gly Phe Glu Tyr Lys Trp Trp Asn Val Leu Pro Gly 
        435                 440                 445             


Asn Met Lys Thr Ser Cys Phe Asn Val Gly Asn Ser Lys Cys Asp Gly 
    450                 455                 460                 


Met Asn Gly Trp Glu Val Ala Gly Asp His Ile Gln Ser Gly Ala Gly 
465                 470                 475                 480 


Gly Ser Asp Asn Asp Tyr Leu Ile Leu Asn Leu His Ile Pro Gly Phe 
                485                 490                 495     


Lys Pro Pro Thr Ser Met Thr Gly Ala Thr Gly Ser Glu Leu Gly Arg 
            500                 505                 510         


Ile Thr Phe Val Phe Glu Thr Leu Cys Ser Ala Asp Cys Val Leu Tyr 
        515                 520                 525             


Phe Met Val Asp Ile Asn Arg Lys Ser Thr Asn Val Val Glu Ser Trp 
    530                 535                 540                 


Gly Gly Thr Lys Glu Lys Gln Ala Tyr Thr His Ile Ile Phe Lys Asn 
545                 550                 555                 560 


Ala Thr Phe Thr Phe Thr Trp Ala Phe Gln Arg Thr Asn Gln Gly Gln 
                565                 570                 575     


Asp Asn Arg Arg Phe Ile Asn Asp Met Val Lys Ile Tyr Ser Ile Thr 
            580                 585                 590         


Ala Thr Asn Ala Val Asp Gly Val Ala Ser Ser Cys Arg Ala Cys Ala 
        595                 600                 605             


Leu Gly Ser Glu Gln Ser Gly Ser Ser Cys Val Pro Cys Pro Pro Gly 
    610                 615                 620                 


His Tyr Ile Glu Lys Glu Thr Asn Gln Cys Lys Glu Cys Pro Pro Asp 
625                 630                 635                 640 


Thr Tyr Leu Ser Ile His Gln Val Tyr Gly Lys Glu Ala Cys Ile Pro 
                645                 650                 655     


Cys Gly Pro Gly Ser Lys Asn Asn Gln Asp His Ser Val Cys Tyr Ser 
            660                 665                 670         


Asp Cys Phe Phe Tyr His Glu Lys Glu Asn Gln Ser Leu His Tyr Asp 
        675                 680                 685             


Phe Ser Asn Leu Ser Ser Val Gly Ser Leu Met Asn Gly Pro Ser Phe 
    690                 695                 700                 


Thr Ser Lys Gly Thr Lys Tyr Phe His Phe Phe Asn Ile Ser Leu Cys 
705                 710                 715                 720 


Gly His Glu Gly Lys Lys Met Ala Leu Cys Thr Asn Asn Ile Thr Asp 
                725                 730                 735     


Phe Thr Val Lys Glu Ile Val Ala Gly Ser Asp Asp Tyr Thr Asn Leu 
            740                 745                 750         


Val Gly Ala Phe Val Cys Gln Ser Thr Ile Ile Pro Ser Glu Ser Lys 
        755                 760                 765             


Gly Phe Arg Ala Ala Leu Ser Ser Gln Ser Ile Ile Leu Ala Asp Thr 
    770                 775                 780                 


Phe Ile Gly Val Thr Val Glu Thr Thr Leu Lys Asn Ile Asn Ile Lys 
785                 790                 795                 800 


Glu Asp Met Phe Pro Val Pro Thr Ser Gln Ile Pro Asp Val His Phe 
                805                 810                 815     


Phe Tyr Lys Ser Ser Thr Ala Thr Thr Ser Cys Ile Asn Gly Arg Ser 
            820                 825                 830         


Thr Ala Val Lys Met Arg Cys Asn Pro Thr Lys Ser Gly Ala Gly Val 
        835                 840                 845             


Ile Ser Val Pro Ser Lys Cys Pro Ala Gly Thr Cys Asp Gly Cys Thr 
    850                 855                 860                 


Phe Tyr Phe Leu Trp Glu Ser Ala Glu Ala Cys Pro Leu Cys Thr Glu 
865                 870                 875                 880 


His Asp Phe His Glu Ile Glu Gly Ala Cys Lys Arg Gly Phe Gln Glu 
                885                 890                 895     


Thr Leu Tyr Val Trp Asn Glu Pro Lys Trp Cys Ile Lys Gly Ile Ser 
            900                 905                 910         


Leu Pro Glu Lys Lys Leu Ala Thr Cys Glu Thr Val Asp Phe Trp Leu 
        915                 920                 925             


Lys Val Gly Ala Gly Val Gly Ala Phe Thr Ala Val Leu Leu Val Ala 
    930                 935                 940                 


Leu Thr Cys Tyr Phe Trp Lys Lys Asn Gln Lys Leu Glu Tyr Lys Tyr 
945                 950                 955                 960 


Ser Lys Leu Val Met Thr Thr Asn Ser Lys Glu Cys Glu Leu Pro Ala 
                965                 970                 975     


Ala Asp Ser Cys Ala Ile Met Glu Gly Glu Asp Asn Glu Glu Glu Val 
            980                 985                 990         


Val Tyr Ser Asn Lys Gln Ser Leu  Leu Gly Lys Leu Lys  Ser Leu Ala 
        995                 1000                 1005             


Thr Lys  Glu Lys Glu Asp His  Phe Glu Ser Val Gln  Leu Lys Thr 
    1010                 1015                 1020             


Ser Arg  Ser Pro Asn Ile 
    1025                 


<210>  1688
<211>  1962
<212>  PRT
<213>  Homo sapiens

<400>  1688

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Trp 
            20                  25                  30          


Gln Tyr Glu Asp Cys Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile 
        35                  40                  45              


Val Ala Ile Asp Glu Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn 
    50                  55                  60                  


Met Leu Ile Lys Gly Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu 
65                  70                  75                  80  


Ser Leu Lys Asp Asn Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys 
                85                  90                  95      


Gln Met Leu Phe Leu Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro 
            100                 105                 110         


Pro Met Asn Ile His Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys 
        115                 120                 125             


Lys Val Gly Thr Ile Ile Tyr His Glu Val Arg Ile Val Val Arg Asp 
    130                 135                 140                 


Arg Asn Asp Asn Ser Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr 
145                 150                 155                 160 


Val Asn Glu Leu Thr Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser 
                165                 170                 175     


Gly Asp Asn Gly Ala Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile 
            180                 185                 190         


Glu Tyr Val Ile Gln Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr 
        195                 200                 205             


Phe Glu Ile Pro Leu Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg 
    210                 215                 220                 


Leu Asn Tyr Glu Asp Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn 
225                 230                 235                 240 


Asp Arg Ala Gln Asn Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu 
                245                 250                 255     


Thr Val Asp Val Leu Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro 
            260                 265                 270         


Cys Val Leu Val Pro Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln 
        275                 280                 285             


Ala Ala Ile Pro Glu Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile 
    290                 295                 300                 


Val Thr Pro Pro Ile Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro 
305                 310                 315                 320 


Pro Ser Asp Arg Pro Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro 
                325                 330                 335     


Glu Asp Tyr Pro Arg Phe Phe His Met His Pro Arg Thr Ala Glu Leu 
            340                 345                 350         


Ser Leu Leu Glu Pro Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu 
        355                 360                 365             


Val Ile Lys Ala Glu Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala 
    370                 375                 380                 


Gly Leu His Ile Glu Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe 
385                 390                 395                 400 


Thr Met Pro Ser Tyr Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly 
                405                 410                 415     


Ala Thr Ile Ser Asp Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val 
            420                 425                 430         


Ala Leu Asp Lys Asp Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu 
        435                 440                 445             


Phe Leu Asn Asp Tyr Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile 
    450                 455                 460                 


Thr Arg Tyr Leu Thr Leu Leu Gln Pro Val Asp Arg Glu Glu Gln Gln 
465                 470                 475                 480 


Thr Tyr Thr Phe Ser Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu 
                485                 490                 495     


Pro Val Ile Val Asn Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro 
            500                 505                 510         


Thr Phe Pro Glu Ile Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg 
        515                 520                 525             


Pro Gly Asp Ser Val Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly 
    530                 535                 540                 


Ser Asn Gly Glu Ile Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp 
545                 550                 555                 560 


Phe Ile Ile Asn Lys Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val 
                565                 570                 575     


Glu Met Ile Val Gly Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp 
            580                 585                 590         


Asn Ala Pro Pro Ala Glu Arg Arg Asn Ser Ile Cys Thr Val Tyr Ile 
        595                 600                 605             


Glu Val Leu Pro Pro Asn Asn Gln Ser Pro Pro Arg Phe Pro Gln Leu 
    610                 615                 620                 


Met Tyr Ser Leu Glu Ile Ser Glu Ala Met Arg Val Gly Ala Val Leu 
625                 630                 635                 640 


Leu Asn Leu Gln Ala Thr Asp Arg Glu Gly Asp Ser Ile Thr Tyr Ala 
                645                 650                 655     


Ile Glu Asn Gly Asp Pro Gln Arg Val Phe Asn Leu Ser Glu Thr Thr 
            660                 665                 670         


Gly Ile Leu Thr Leu Gly Lys Ala Leu Asp Arg Glu Ser Thr Asp Arg 
        675                 680                 685             


Tyr Ile Leu Ile Ile Thr Ala Ser Asp Gly Arg Pro Asp Gly Thr Ser 
    690                 695                 700                 


Thr Ala Thr Val Asn Ile Val Val Thr Asp Val Asn Asp Asn Ala Pro 
705                 710                 715                 720 


Val Phe Asp Pro Tyr Leu Pro Arg Asn Leu Ser Val Val Glu Glu Glu 
                725                 730                 735     


Ala Asn Ala Phe Val Gly Gln Val Lys Ala Thr Asp Pro Asp Ala Gly 
            740                 745                 750         


Ile Asn Gly Gln Val His Tyr Ser Leu Gly Asn Phe Asn Asn Leu Phe 
        755                 760                 765             


Arg Ile Thr Ser Asn Gly Ser Ile Tyr Thr Ala Val Lys Leu Asn Arg 
    770                 775                 780                 


Glu Val Arg Asp Tyr Tyr Glu Leu Val Val Val Ala Thr Asp Gly Ala 
785                 790                 795                 800 


Val His Pro Arg His Ser Thr Leu Thr Leu Ala Ile Lys Val Leu Asp 
                805                 810                 815     


Ile Asp Asp Asn Ser Pro Val Phe Thr Asn Ser Thr Tyr Thr Val Leu 
            820                 825                 830         


Val Glu Glu Asn Leu Pro Ala Gly Thr Thr Ile Leu Gln Ile Glu Ala 
        835                 840                 845             


Lys Asp Val Asp Leu Gly Ala Asn Val Ser Tyr Arg Ile Arg Ser Pro 
    850                 855                 860                 


Glu Val Lys His Phe Phe Ala Leu His Pro Phe Thr Gly Glu Leu Ser 
865                 870                 875                 880 


Leu Leu Arg Ser Leu Asp Tyr Glu Ala Phe Pro Asp Gln Glu Ala Ser 
                885                 890                 895     


Ile Thr Phe Leu Val Glu Ala Phe Asp Ile Tyr Gly Thr Met Pro Pro 
            900                 905                 910         


Gly Ile Ala Thr Val Thr Val Ile Val Lys Asp Met Asn Asp Tyr Pro 
        915                 920                 925             


Pro Val Phe Ser Lys Arg Ile Tyr Lys Gly Met Val Ala Pro Asp Ala 
    930                 935                 940                 


Val Lys Gly Thr Pro Ile Thr Thr Val Tyr Ala Glu Asp Ala Asp Pro 
945                 950                 955                 960 


Pro Gly Leu Pro Ala Ser Arg Val Arg Tyr Arg Val Asp Asp Val Gln 
                965                 970                 975     


Phe Pro Tyr Pro Ala Ser Ile Phe Glu Val Glu Glu Asp Ser Gly Arg 
            980                 985                 990         


Val Ile Thr Arg Val Asn Leu Asn  Glu Glu Pro Thr Thr  Ile Phe Lys 
        995                 1000                 1005             


Leu Val  Val Val Ala Phe Asp  Asp Gly Glu Pro Val  Met Ser Ser 
    1010                 1015                 1020             


Ser Ala  Thr Val Lys Ile Leu  Val Leu His Pro Gly  Glu Ile Pro 
    1025                 1030                 1035             


Arg Phe  Thr Gln Glu Glu Tyr  Arg Pro Pro Pro Val  Ser Glu Leu 
    1040                 1045                 1050             


Ala Thr  Lys Gly Thr Met Val  Gly Val Ile Ser Ala  Ala Ala Ile 
    1055                 1060                 1065             


Asn Gln  Ser Ile Val Tyr Ser  Ile Val Ser Gly Asn  Glu Glu Asp 
    1070                 1075                 1080             


Thr Phe  Gly Ile Asn Asn Ile  Thr Gly Val Ile Tyr  Val Asn Gly 
    1085                 1090                 1095             


Pro Leu  Asp Tyr Glu Thr Arg  Thr Ser Tyr Val Leu  Arg Val Gln 
    1100                 1105                 1110             


Ala Asp  Ser Leu Glu Val Val  Leu Ala Asn Leu Arg  Val Pro Ser 
    1115                 1120                 1125             


Lys Ser  Asn Thr Ala Lys Val  Tyr Ile Glu Ile Gln  Asp Glu Asn 
    1130                 1135                 1140             


Asn His  Pro Pro Val Phe Gln  Lys Lys Phe Tyr Ile  Gly Gly Val 
    1145                 1150                 1155             


Ser Glu  Asp Ala Arg Met Phe  Thr Ser Val Leu Arg  Val Lys Ala 
    1160                 1165                 1170             


Thr Asp  Lys Asp Thr Gly Asn  Tyr Ser Val Met Ala  Tyr Arg Leu 
    1175                 1180                 1185             


Ile Ile  Pro Pro Ile Lys Glu  Gly Lys Glu Gly Phe  Val Val Glu 
    1190                 1195                 1200             


Thr Tyr  Thr Gly Leu Ile Lys  Thr Ala Met Leu Phe  His Asn Met 
    1205                 1210                 1215             


Arg Arg  Ser Tyr Phe Lys Phe  Gln Val Ile Ala Thr  Asp Asp Tyr 
    1220                 1225                 1230             


Gly Lys  Gly Leu Ser Gly Lys  Ala Asp Val Leu Val  Ser Val Val 
    1235                 1240                 1245             


Asn Gln  Leu Asp Met Gln Val  Ile Val Ser Asn Val  Pro Pro Thr 
    1250                 1255                 1260             


Leu Val  Glu Lys Lys Ile Glu  Asp Leu Thr Glu Ile  Leu Asp Arg 
    1265                 1270                 1275             


Tyr Val  Gln Glu Gln Ile Pro  Gly Ala Lys Val Val  Val Glu Ser 
    1280                 1285                 1290             


Ile Gly  Ala Arg Arg His Gly  Asp Ala Phe Ser Leu  Glu Asp Tyr 
    1295                 1300                 1305             


Thr Lys  Cys Asp Leu Thr Val  Tyr Ala Ile Asp Pro  Gln Thr Asn 
    1310                 1315                 1320             


Arg Ala  Ile Asp Arg Asn Glu  Leu Phe Lys Phe Leu  Asp Gly Lys 
    1325                 1330                 1335             


Leu Leu  Asp Ile Asn Lys Asp  Phe Gln Pro Tyr Tyr  Gly Glu Gly 
    1340                 1345                 1350             


Gly Arg  Ile Leu Glu Ile Arg  Thr Pro Glu Ala Val  Thr Ser Ile 
    1355                 1360                 1365             


Lys Lys  Arg Gly Glu Ser Leu  Gly Tyr Thr Glu Gly  Ala Leu Leu 
    1370                 1375                 1380             


Ala Leu  Ala Phe Ile Ile Ile  Leu Cys Cys Ile Pro  Ala Ile Leu 
    1385                 1390                 1395             


Val Val  Leu Val Ser Tyr Arg  Gln Phe Lys Val Arg  Gln Ala Glu 
    1400                 1405                 1410             


Cys Thr  Lys Thr Ala Arg Ile  Gln Ala Ala Leu Pro  Ala Ala Lys 
    1415                 1420                 1425             


Pro Ala  Val Pro Ala Pro Ala  Pro Val Ala Ala Pro  Pro Pro Pro 
    1430                 1435                 1440             


Pro Pro  Pro Pro Pro Gly Ala  His Leu Tyr Glu Glu  Leu Gly Asp 
    1445                 1450                 1455             


Ser Ser  Met His Asn Leu Phe  Leu Leu Tyr His Phe  Gln Gln Ser 
    1460                 1465                 1470             


Arg Gly  Asn Asn Ser Val Ser  Glu Asp Arg Lys His  Gln Gln Val 
    1475                 1480                 1485             


Val Met  Pro Phe Ser Ser Asn  Thr Ile Glu Ala His  Lys Ser Ala 
    1490                 1495                 1500             


His Val  Asp Gly Ser Leu Lys  Ser Asn Lys Leu Lys  Ser Ala Arg 
    1505                 1510                 1515             


Lys Phe  Thr Phe Leu Ser Asp  Glu Asp Asp Leu Ser  Ala His Asn 
    1520                 1525                 1530             


Pro Leu  Tyr Lys Glu Asn Ile  Ser Gln Val Ser Thr  Asn Ser Asp 
    1535                 1540                 1545             


Ile Ser  Gln Arg Thr Asp Phe  Val Asp Pro Phe Ser  Pro Lys Ile 
    1550                 1555                 1560             


Gln Ala  Lys Ser Lys Ser Leu  Arg Gly Pro Arg Glu  Lys Ile Gln 
    1565                 1570                 1575             


Arg Leu  Trp Ser Gln Ser Val  Ser Leu Pro Arg Arg  Leu Met Arg 
    1580                 1585                 1590             


Lys Val  Pro Asn Arg Pro Glu  Ile Ile Asp Leu Gln  Gln Trp Gln 
    1595                 1600                 1605             


Gly Thr  Arg Gln Lys Ala Glu  Asn Glu Asn Thr Gly  Ile Cys Thr 
    1610                 1615                 1620             


Asn Lys  Arg Gly Ser Ser Asn  Pro Leu Leu Thr Thr  Glu Glu Ala 
    1625                 1630                 1635             


Asn Leu  Thr Glu Lys Glu Glu  Ile Arg Gln Gly Glu  Thr Leu Met 
    1640                 1645                 1650             


Ile Glu  Gly Thr Glu Gln Leu  Lys Ser Leu Ser Ser  Asp Ser Ser 
    1655                 1660                 1665             


Phe Cys  Phe Pro Arg Pro His  Phe Ser Phe Ser Thr  Leu Pro Thr 
    1670                 1675                 1680             


Val Ser  Arg Thr Val Glu Leu  Lys Ser Glu Pro Asn  Val Ile Ser 
    1685                 1690                 1695             


Ser Pro  Ala Glu Cys Ser Leu  Glu Leu Ser Pro Ser  Arg Pro Cys 
    1700                 1705                 1710             


Val Leu  His Ser Ser Leu Ser  Arg Arg Glu Thr Pro  Ile Cys Met 
    1715                 1720                 1725             


Leu Pro  Ile Glu Thr Glu Arg  Asn Ile Phe Glu Asn  Phe Ala His 
    1730                 1735                 1740             


Pro Pro  Asn Ile Ser Pro Ser  Ala Cys Pro Leu Pro  Pro Pro Pro 
    1745                 1750                 1755             


Pro Ile  Ser Pro Pro Ser Pro  Pro Pro Ala Pro Ala  Pro Leu Ala 
    1760                 1765                 1770             


Pro Pro  Pro Asp Ile Ser Pro  Phe Ser Leu Phe Cys  Pro Pro Pro 
    1775                 1780                 1785             


Ser Pro  Pro Ser Ile Pro Leu  Pro Leu Pro Pro Pro  Thr Phe Phe 
    1790                 1795                 1800             


Pro Leu  Ser Val Ser Thr Ser  Gly Pro Pro Thr Pro  Pro Leu Leu 
    1805                 1810                 1815             


Pro Pro  Phe Pro Thr Pro Leu  Pro Pro Pro Pro Pro  Ser Ile Pro 
    1820                 1825                 1830             


Cys Pro  Pro Pro Pro Ser Ala  Ser Phe Leu Ser Thr  Glu Cys Val 
    1835                 1840                 1845             


Cys Ile  Thr Gly Val Lys Cys  Thr Thr Asn Leu Met  Pro Ala Glu 
    1850                 1855                 1860             


Lys Ile  Lys Ser Ser Met Thr  Gln Leu Ser Thr Thr  Thr Val Cys 
    1865                 1870                 1875             


Lys Thr  Asp Pro Gln Arg Glu  Pro Lys Gly Ile Leu  Arg His Val 
    1880                 1885                 1890             


Lys Asn  Leu Ala Glu Leu Glu  Lys Ser Val Ala Asn  Met Tyr Ser 
    1895                 1900                 1905             


Gln Ile  Glu Lys Asn Tyr Leu  Arg Thr Asn Val Ser  Glu Leu Gln 
    1910                 1915                 1920             


Thr Met  Cys Pro Ser Glu Val  Thr Asn Met Glu Ile  Thr Ser Glu 
    1925                 1930                 1935             


Gln Asn  Lys Gly Ser Leu Asn  Asn Ile Val Glu Gly  Thr Glu Lys 
    1940                 1945                 1950             


Gln Ser  His Ser Gln Ser Thr  Ser Leu 
    1955                 1960         


<210>  1689
<211>  1957
<212>  PRT
<213>  Homo sapiens

<400>  1689

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Cys 
            20                  25                  30          


Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu 
        35                  40                  45              


Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly 
    50                  55                  60                  


Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn 
65                  70                  75                  80  


Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln Met Leu Phe Leu 
                85                  90                  95      


Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro Pro Met Asn Ile His 
            100                 105                 110         


Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys Lys Val Gly Thr Ile 
        115                 120                 125             


Ile Tyr His Glu Val Arg Ile Val Val Arg Asp Arg Asn Asp Asn Ser 
    130                 135                 140                 


Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr 
145                 150                 155                 160 


Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala 
                165                 170                 175     


Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln 
            180                 185                 190         


Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu 
        195                 200                 205             


Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp 
    210                 215                 220                 


Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn 
225                 230                 235                 240 


Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu Thr Val Asp Val Leu 
                245                 250                 255     


Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro Cys Val Leu Val Pro 
            260                 265                 270         


Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu 
        275                 280                 285             


Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile Val Thr Pro Pro Ile 
    290                 295                 300                 


Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro 
305                 310                 315                 320 


Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg 
                325                 330                 335     


Phe Phe His Met His Pro Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro 
            340                 345                 350         


Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu Val Ile Lys Ala Glu 
        355                 360                 365             


Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala Gly Leu His Ile Glu 
    370                 375                 380                 


Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr 
385                 390                 395                 400 


Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly Ala Thr Ile Ser Asp 
                405                 410                 415     


Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val Ala Leu Asp Lys Asp 
            420                 425                 430         


Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu Phe Leu Asn Asp Tyr 
        435                 440                 445             


Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr 
    450                 455                 460                 


Leu Leu Gln Pro Val Asp Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser 
465                 470                 475                 480 


Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu Pro Val Ile Val Asn 
                485                 490                 495     


Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile 
            500                 505                 510         


Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg Pro Gly Asp Ser Val 
        515                 520                 525             


Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile 
    530                 535                 540                 


Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys 
545                 550                 555                 560 


Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val Glu Met Ile Val Gly 
                565                 570                 575     


Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp Asn Ala Pro Pro Ala 
            580                 585                 590         


Glu Arg Arg Asn Ser Ile Cys Thr Val Tyr Ile Glu Val Leu Pro Pro 
        595                 600                 605             


Asn Asn Gln Ser Pro Pro Arg Phe Pro Gln Leu Met Tyr Ser Leu Glu 
    610                 615                 620                 


Ile Ser Glu Ala Met Arg Val Gly Ala Val Leu Leu Asn Leu Gln Ala 
625                 630                 635                 640 


Thr Asp Arg Glu Gly Asp Ser Ile Thr Tyr Ala Ile Glu Asn Gly Asp 
                645                 650                 655     


Pro Gln Arg Val Phe Asn Leu Ser Glu Thr Thr Gly Ile Leu Thr Leu 
            660                 665                 670         


Gly Lys Ala Leu Asp Arg Glu Ser Thr Asp Arg Tyr Ile Leu Ile Ile 
        675                 680                 685             


Thr Ala Ser Asp Gly Arg Pro Asp Gly Thr Ser Thr Ala Thr Val Asn 
    690                 695                 700                 


Ile Val Val Thr Asp Val Asn Asp Asn Ala Pro Val Phe Asp Pro Tyr 
705                 710                 715                 720 


Leu Pro Arg Asn Leu Ser Val Val Glu Glu Glu Ala Asn Ala Phe Val 
                725                 730                 735     


Gly Gln Val Lys Ala Thr Asp Pro Asp Ala Gly Ile Asn Gly Gln Val 
            740                 745                 750         


His Tyr Ser Leu Gly Asn Phe Asn Asn Leu Phe Arg Ile Thr Ser Asn 
        755                 760                 765             


Gly Ser Ile Tyr Thr Ala Val Lys Leu Asn Arg Glu Val Arg Asp Tyr 
    770                 775                 780                 


Tyr Glu Leu Val Val Val Ala Thr Asp Gly Ala Val His Pro Arg His 
785                 790                 795                 800 


Ser Thr Leu Thr Leu Ala Ile Lys Val Leu Asp Ile Asp Asp Asn Ser 
                805                 810                 815     


Pro Val Phe Thr Asn Ser Thr Tyr Thr Val Leu Val Glu Glu Asn Leu 
            820                 825                 830         


Pro Ala Gly Thr Thr Ile Leu Gln Ile Glu Ala Lys Asp Val Asp Leu 
        835                 840                 845             


Gly Ala Asn Val Ser Tyr Arg Ile Arg Ser Pro Glu Val Lys His Phe 
    850                 855                 860                 


Phe Ala Leu His Pro Phe Thr Gly Glu Leu Ser Leu Leu Arg Ser Leu 
865                 870                 875                 880 


Asp Tyr Glu Ala Phe Pro Asp Gln Glu Ala Ser Ile Thr Phe Leu Val 
                885                 890                 895     


Glu Ala Phe Asp Ile Tyr Gly Thr Met Pro Pro Gly Ile Ala Thr Val 
            900                 905                 910         


Thr Val Ile Val Lys Asp Met Asn Asp Tyr Pro Pro Val Phe Ser Lys 
        915                 920                 925             


Arg Ile Tyr Lys Gly Met Val Ala Pro Asp Ala Val Lys Gly Thr Pro 
    930                 935                 940                 


Ile Thr Thr Val Tyr Ala Glu Asp Ala Asp Pro Pro Gly Leu Pro Ala 
945                 950                 955                 960 


Ser Arg Val Arg Tyr Arg Val Asp Asp Val Gln Phe Pro Tyr Pro Ala 
                965                 970                 975     


Ser Ile Phe Glu Val Glu Glu Asp Ser Gly Arg Val Ile Thr Arg Val 
            980                 985                 990         


Asn Leu Asn Glu Glu Pro Thr Thr  Ile Phe Lys Leu Val  Val Val Ala 
        995                 1000                 1005             


Phe Asp  Asp Gly Glu Pro Val  Met Ser Ser Ser Ala  Thr Val Lys 
    1010                 1015                 1020             


Ile Leu  Val Leu His Pro Gly  Glu Ile Pro Arg Phe  Thr Gln Glu 
    1025                 1030                 1035             


Glu Tyr  Arg Pro Pro Pro Val  Ser Glu Leu Ala Thr  Lys Gly Thr 
    1040                 1045                 1050             


Met Val  Gly Val Ile Ser Ala  Ala Ala Ile Asn Gln  Ser Ile Val 
    1055                 1060                 1065             


Tyr Ser  Ile Val Ser Gly Asn  Glu Glu Asp Thr Phe  Gly Ile Asn 
    1070                 1075                 1080             


Asn Ile  Thr Gly Val Ile Tyr  Val Asn Gly Pro Leu  Asp Tyr Glu 
    1085                 1090                 1095             


Thr Arg  Thr Ser Tyr Val Leu  Arg Val Gln Ala Asp  Ser Leu Glu 
    1100                 1105                 1110             


Val Val  Leu Ala Asn Leu Arg  Val Pro Ser Lys Ser  Asn Thr Ala 
    1115                 1120                 1125             


Lys Val  Tyr Ile Glu Ile Gln  Asp Glu Asn Asn His  Pro Pro Val 
    1130                 1135                 1140             


Phe Gln  Lys Lys Phe Tyr Ile  Gly Gly Val Ser Glu  Asp Ala Arg 
    1145                 1150                 1155             


Met Phe  Thr Ser Val Leu Arg  Val Lys Ala Thr Asp  Lys Asp Thr 
    1160                 1165                 1170             


Gly Asn  Tyr Ser Val Met Ala  Tyr Arg Leu Ile Ile  Pro Pro Ile 
    1175                 1180                 1185             


Lys Glu  Gly Lys Glu Gly Phe  Val Val Glu Thr Tyr  Thr Gly Leu 
    1190                 1195                 1200             


Ile Lys  Thr Ala Met Leu Phe  His Asn Met Arg Arg  Ser Tyr Phe 
    1205                 1210                 1215             


Lys Phe  Gln Val Ile Ala Thr  Asp Asp Tyr Gly Lys  Gly Leu Ser 
    1220                 1225                 1230             


Gly Lys  Ala Asp Val Leu Val  Ser Val Val Asn Gln  Leu Asp Met 
    1235                 1240                 1245             


Gln Val  Ile Val Ser Asn Val  Pro Pro Thr Leu Val  Glu Lys Lys 
    1250                 1255                 1260             


Ile Glu  Asp Leu Thr Glu Ile  Leu Asp Arg Tyr Val  Gln Glu Gln 
    1265                 1270                 1275             


Ile Pro  Gly Ala Lys Val Val  Val Glu Ser Ile Gly  Ala Arg Arg 
    1280                 1285                 1290             


His Gly  Asp Ala Phe Ser Leu  Glu Asp Tyr Thr Lys  Cys Asp Leu 
    1295                 1300                 1305             


Thr Val  Tyr Ala Ile Asp Pro  Gln Thr Asn Arg Ala  Ile Asp Arg 
    1310                 1315                 1320             


Asn Glu  Leu Phe Lys Phe Leu  Asp Gly Lys Leu Leu  Asp Ile Asn 
    1325                 1330                 1335             


Lys Asp  Phe Gln Pro Tyr Tyr  Gly Glu Gly Gly Arg  Ile Leu Glu 
    1340                 1345                 1350             


Ile Arg  Thr Pro Glu Ala Val  Thr Ser Ile Lys Lys  Arg Gly Glu 
    1355                 1360                 1365             


Ser Leu  Gly Tyr Thr Glu Gly  Ala Leu Leu Ala Leu  Ala Phe Ile 
    1370                 1375                 1380             


Ile Ile  Leu Cys Cys Ile Pro  Ala Ile Leu Val Val  Leu Val Ser 
    1385                 1390                 1395             


Tyr Arg  Gln Phe Lys Val Arg  Gln Ala Glu Cys Thr  Lys Thr Ala 
    1400                 1405                 1410             


Arg Ile  Gln Ala Ala Leu Pro  Ala Ala Lys Pro Ala  Val Pro Ala 
    1415                 1420                 1425             


Pro Ala  Pro Val Ala Ala Pro  Pro Pro Pro Pro Pro  Pro Pro Pro 
    1430                 1435                 1440             


Gly Ala  His Leu Tyr Glu Glu  Leu Gly Asp Ser Ser  Met His Asn 
    1445                 1450                 1455             


Leu Phe  Leu Leu Tyr His Phe  Gln Gln Ser Arg Gly  Asn Asn Ser 
    1460                 1465                 1470             


Val Ser  Glu Asp Arg Lys His  Gln Gln Val Val Met  Pro Phe Ser 
    1475                 1480                 1485             


Ser Asn  Thr Ile Glu Ala His  Lys Ser Ala His Val  Asp Gly Ser 
    1490                 1495                 1500             


Leu Lys  Ser Asn Lys Leu Lys  Ser Ala Arg Lys Phe  Thr Phe Leu 
    1505                 1510                 1515             


Ser Asp  Glu Asp Asp Leu Ser  Ala His Asn Pro Leu  Tyr Lys Glu 
    1520                 1525                 1530             


Asn Ile  Ser Gln Val Ser Thr  Asn Ser Asp Ile Ser  Gln Arg Thr 
    1535                 1540                 1545             


Asp Phe  Val Asp Pro Phe Ser  Pro Lys Ile Gln Ala  Lys Ser Lys 
    1550                 1555                 1560             


Ser Leu  Arg Gly Pro Arg Glu  Lys Ile Gln Arg Leu  Trp Ser Gln 
    1565                 1570                 1575             


Ser Val  Ser Leu Pro Arg Arg  Leu Met Arg Lys Val  Pro Asn Arg 
    1580                 1585                 1590             


Pro Glu  Ile Ile Asp Leu Gln  Gln Trp Gln Gly Thr  Arg Gln Lys 
    1595                 1600                 1605             


Ala Glu  Asn Glu Asn Thr Gly  Ile Cys Thr Asn Lys  Arg Gly Ser 
    1610                 1615                 1620             


Ser Asn  Pro Leu Leu Thr Thr  Glu Glu Ala Asn Leu  Thr Glu Lys 
    1625                 1630                 1635             


Glu Glu  Ile Arg Gln Gly Glu  Thr Leu Met Ile Glu  Gly Thr Glu 
    1640                 1645                 1650             


Gln Leu  Lys Ser Leu Ser Ser  Asp Ser Ser Phe Cys  Phe Pro Arg 
    1655                 1660                 1665             


Pro His  Phe Ser Phe Ser Thr  Leu Pro Thr Val Ser  Arg Thr Val 
    1670                 1675                 1680             


Glu Leu  Lys Ser Glu Pro Asn  Val Ile Ser Ser Pro  Ala Glu Cys 
    1685                 1690                 1695             


Ser Leu  Glu Leu Ser Pro Ser  Arg Pro Cys Val Leu  His Ser Ser 
    1700                 1705                 1710             


Leu Ser  Arg Arg Glu Thr Pro  Ile Cys Met Leu Pro  Ile Glu Thr 
    1715                 1720                 1725             


Glu Arg  Asn Ile Phe Glu Asn  Phe Ala His Pro Pro  Asn Ile Ser 
    1730                 1735                 1740             


Pro Ser  Ala Cys Pro Leu Pro  Pro Pro Pro Pro Ile  Ser Pro Pro 
    1745                 1750                 1755             


Ser Pro  Pro Pro Ala Pro Ala  Pro Leu Ala Pro Pro  Pro Asp Ile 
    1760                 1765                 1770             


Ser Pro  Phe Ser Leu Phe Cys  Pro Pro Pro Ser Pro  Pro Ser Ile 
    1775                 1780                 1785             


Pro Leu  Pro Leu Pro Pro Pro  Thr Phe Phe Pro Leu  Ser Val Ser 
    1790                 1795                 1800             


Thr Ser  Gly Pro Pro Thr Pro  Pro Leu Leu Pro Pro  Phe Pro Thr 
    1805                 1810                 1815             


Pro Leu  Pro Pro Pro Pro Pro  Ser Ile Pro Cys Pro  Pro Pro Pro 
    1820                 1825                 1830             


Ser Ala  Ser Phe Leu Ser Thr  Glu Cys Val Cys Ile  Thr Gly Val 
    1835                 1840                 1845             


Lys Cys  Thr Thr Asn Leu Met  Pro Ala Glu Lys Ile  Lys Ser Ser 
    1850                 1855                 1860             


Met Thr  Gln Leu Ser Thr Thr  Thr Val Cys Lys Thr  Asp Pro Gln 
    1865                 1870                 1875             


Arg Glu  Pro Lys Gly Ile Leu  Arg His Val Lys Asn  Leu Ala Glu 
    1880                 1885                 1890             


Leu Glu  Lys Ser Val Ala Asn  Met Tyr Ser Gln Ile  Glu Lys Asn 
    1895                 1900                 1905             


Tyr Leu  Arg Thr Asn Val Ser  Glu Leu Gln Thr Met  Cys Pro Ser 
    1910                 1915                 1920             


Glu Val  Thr Asn Met Glu Ile  Thr Ser Glu Gln Asn  Lys Gly Ser 
    1925                 1930                 1935             


Leu Asn  Asn Ile Val Glu Gly  Thr Glu Lys Gln Ser  His Ser Gln 
    1940                 1945                 1950             


Ser Thr  Ser Leu 
    1955         


<210>  1690
<211>  1886
<212>  PRT
<213>  Homo sapiens

<400>  1690

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Cys 
            20                  25                  30          


Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu 
        35                  40                  45              


Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly 
    50                  55                  60                  


Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn 
65                  70                  75                  80  


Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln Met Leu Phe Leu 
                85                  90                  95      


Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro Pro Met Asn Ile His 
            100                 105                 110         


Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys Lys Val Gly Thr Ile 
        115                 120                 125             


Ile Tyr His Glu Val Arg Ile Val Val Arg Asp Arg Asn Asp Asn Ser 
    130                 135                 140                 


Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr 
145                 150                 155                 160 


Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala 
                165                 170                 175     


Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln 
            180                 185                 190         


Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu 
        195                 200                 205             


Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp 
    210                 215                 220                 


Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn 
225                 230                 235                 240 


Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu Thr Val Asp Val Leu 
                245                 250                 255     


Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro Cys Val Leu Val Pro 
            260                 265                 270         


Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu 
        275                 280                 285             


Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile Val Thr Pro Pro Ile 
    290                 295                 300                 


Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro 
305                 310                 315                 320 


Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg 
                325                 330                 335     


Phe Phe His Met His Pro Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro 
            340                 345                 350         


Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu Val Ile Lys Ala Glu 
        355                 360                 365             


Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala Gly Leu His Ile Glu 
    370                 375                 380                 


Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr 
385                 390                 395                 400 


Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly Ala Thr Ile Ser Asp 
                405                 410                 415     


Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val Ala Leu Asp Lys Asp 
            420                 425                 430         


Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu Phe Leu Asn Asp Tyr 
        435                 440                 445             


Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr 
    450                 455                 460                 


Leu Leu Gln Pro Val Asp Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser 
465                 470                 475                 480 


Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu Pro Val Ile Val Asn 
                485                 490                 495     


Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile 
            500                 505                 510         


Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg Pro Gly Asp Ser Val 
        515                 520                 525             


Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile 
    530                 535                 540                 


Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys 
545                 550                 555                 560 


Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val Glu Met Ile Val Gly 
                565                 570                 575     


Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp Asn Ala Pro Pro Ala 
            580                 585                 590         


Glu Arg Ser Thr Gly Ile Leu Thr Leu Gly Lys Ala Leu Asp Arg Glu 
        595                 600                 605             


Ser Thr Asp Arg Tyr Ile Leu Ile Ile Thr Ala Ser Asp Gly Arg Pro 
    610                 615                 620                 


Asp Gly Thr Ser Thr Ala Thr Val Asn Ile Val Val Thr Asp Val Asn 
625                 630                 635                 640 


Asp Asn Ala Pro Val Phe Asp Pro Tyr Leu Pro Arg Asn Leu Ser Val 
                645                 650                 655     


Val Glu Glu Glu Ala Asn Ala Phe Val Gly Gln Val Lys Ala Thr Asp 
            660                 665                 670         


Pro Asp Ala Gly Ile Asn Gly Gln Val His Tyr Ser Leu Gly Asn Phe 
        675                 680                 685             


Asn Asn Leu Phe Arg Ile Thr Ser Asn Gly Ser Ile Tyr Thr Ala Val 
    690                 695                 700                 


Lys Leu Asn Arg Glu Val Arg Asp Tyr Tyr Glu Leu Val Val Val Ala 
705                 710                 715                 720 


Thr Asp Gly Ala Val His Pro Arg His Ser Thr Leu Thr Leu Ala Ile 
                725                 730                 735     


Lys Val Leu Asp Ile Asp Asp Asn Ser Pro Val Phe Thr Asn Ser Thr 
            740                 745                 750         


Tyr Thr Val Leu Val Glu Glu Asn Leu Pro Ala Gly Thr Thr Ile Leu 
        755                 760                 765             


Gln Ile Glu Ala Lys Asp Val Asp Leu Gly Ala Asn Val Ser Tyr Arg 
    770                 775                 780                 


Ile Arg Ser Pro Glu Val Lys His Phe Phe Ala Leu His Pro Phe Thr 
785                 790                 795                 800 


Gly Glu Leu Ser Leu Leu Arg Ser Leu Asp Tyr Glu Ala Phe Pro Asp 
                805                 810                 815     


Gln Glu Ala Ser Ile Thr Phe Leu Val Glu Ala Phe Asp Ile Tyr Gly 
            820                 825                 830         


Thr Met Pro Pro Gly Ile Ala Thr Val Thr Val Ile Val Lys Asp Met 
        835                 840                 845             


Asn Asp Tyr Pro Pro Val Phe Ser Lys Arg Ile Tyr Lys Gly Met Val 
    850                 855                 860                 


Ala Pro Asp Ala Val Lys Gly Thr Pro Ile Thr Thr Val Tyr Ala Glu 
865                 870                 875                 880 


Asp Ala Asp Pro Pro Gly Leu Pro Ala Ser Arg Val Arg Tyr Arg Val 
                885                 890                 895     


Asp Asp Val Gln Phe Pro Tyr Pro Ala Ser Ile Phe Glu Val Glu Glu 
            900                 905                 910         


Asp Ser Gly Arg Val Ile Thr Arg Val Asn Leu Asn Glu Glu Pro Thr 
        915                 920                 925             


Thr Ile Phe Lys Leu Val Val Val Ala Phe Asp Asp Gly Glu Pro Val 
    930                 935                 940                 


Met Ser Ser Ser Ala Thr Val Lys Ile Leu Val Leu His Pro Gly Glu 
945                 950                 955                 960 


Ile Pro Arg Phe Thr Gln Glu Glu Tyr Arg Pro Pro Pro Val Ser Glu 
                965                 970                 975     


Leu Ala Thr Lys Gly Thr Met Val Gly Val Ile Ser Ala Ala Ala Ile 
            980                 985                 990         


Asn Gln Ser Ile Val Tyr Ser Ile  Val Ser Gly Asn Glu  Glu Asp Thr 
        995                 1000                 1005             


Phe Gly  Ile Asn Asn Ile Thr  Gly Val Ile Tyr Val  Asn Gly Pro 
    1010                 1015                 1020             


Leu Asp  Tyr Glu Thr Arg Thr  Ser Tyr Val Leu Arg  Val Gln Ala 
    1025                 1030                 1035             


Asp Ser  Leu Glu Val Val Leu  Ala Asn Leu Arg Val  Pro Ser Lys 
    1040                 1045                 1050             


Ser Asn  Thr Ala Lys Val Tyr  Ile Glu Ile Gln Asp  Glu Asn Asn 
    1055                 1060                 1065             


His Pro  Pro Val Phe Gln Lys  Lys Phe Tyr Ile Gly  Gly Val Ser 
    1070                 1075                 1080             


Glu Asp  Ala Arg Met Phe Thr  Ser Val Leu Arg Val  Lys Ala Thr 
    1085                 1090                 1095             


Asp Lys  Asp Thr Gly Asn Tyr  Ser Val Met Ala Tyr  Arg Leu Ile 
    1100                 1105                 1110             


Ile Pro  Pro Ile Lys Glu Gly  Lys Glu Gly Phe Val  Val Glu Thr 
    1115                 1120                 1125             


Tyr Thr  Gly Leu Ile Lys Thr  Ala Met Leu Phe His  Asn Met Arg 
    1130                 1135                 1140             


Arg Ser  Tyr Phe Lys Phe Gln  Val Ile Ala Thr Asp  Asp Tyr Gly 
    1145                 1150                 1155             


Lys Gly  Leu Ser Gly Lys Ala  Asp Val Leu Val Ser  Val Val Asn 
    1160                 1165                 1170             


Gln Leu  Asp Met Gln Val Ile  Val Ser Asn Val Pro  Pro Thr Leu 
    1175                 1180                 1185             


Val Glu  Lys Lys Ile Glu Asp  Leu Thr Glu Ile Leu  Asp Arg Tyr 
    1190                 1195                 1200             


Val Gln  Glu Gln Ile Pro Gly  Ala Lys Val Val Val  Glu Ser Ile 
    1205                 1210                 1215             


Gly Ala  Arg Arg His Gly Asp  Ala Phe Ser Leu Glu  Asp Tyr Thr 
    1220                 1225                 1230             


Lys Cys  Asp Leu Thr Val Tyr  Ala Ile Asp Pro Gln  Thr Asn Arg 
    1235                 1240                 1245             


Ala Ile  Asp Arg Asn Glu Leu  Phe Lys Phe Leu Asp  Gly Lys Leu 
    1250                 1255                 1260             


Leu Asp  Ile Asn Lys Asp Phe  Gln Pro Tyr Tyr Gly  Glu Gly Gly 
    1265                 1270                 1275             


Arg Ile  Leu Glu Ile Arg Thr  Pro Glu Ala Val Thr  Ser Ile Lys 
    1280                 1285                 1290             


Lys Arg  Gly Glu Ser Leu Gly  Tyr Thr Glu Gly Ala  Leu Leu Ala 
    1295                 1300                 1305             


Leu Ala  Phe Ile Ile Ile Leu  Cys Cys Ile Pro Ala  Ile Leu Val 
    1310                 1315                 1320             


Val Leu  Val Ser Tyr Arg Gln  Phe Lys Val Arg Gln  Ala Glu Cys 
    1325                 1330                 1335             


Thr Lys  Thr Ala Arg Ile Gln  Ala Ala Leu Pro Ala  Ala Lys Pro 
    1340                 1345                 1350             


Ala Val  Pro Ala Pro Ala Pro  Val Ala Ala Pro Pro  Pro Pro Pro 
    1355                 1360                 1365             


Pro Pro  Pro Pro Gly Ala His  Leu Tyr Glu Glu Leu  Gly Asp Ser 
    1370                 1375                 1380             


Ser Met  His Asn Leu Phe Leu  Leu Tyr His Phe Gln  Gln Ser Arg 
    1385                 1390                 1395             


Gly Asn  Asn Ser Val Ser Glu  Asp Arg Lys His Gln  Gln Val Val 
    1400                 1405                 1410             


Met Pro  Phe Ser Ser Asn Thr  Ile Glu Ala His Lys  Ser Ala His 
    1415                 1420                 1425             


Val Asp  Gly Ser Leu Lys Ser  Asn Lys Leu Lys Ser  Ala Arg Lys 
    1430                 1435                 1440             


Phe Thr  Phe Leu Ser Asp Glu  Asp Asp Leu Ser Ala  His Asn Pro 
    1445                 1450                 1455             


Leu Tyr  Lys Glu Asn Ile Ser  Gln Val Ser Thr Asn  Ser Asp Ile 
    1460                 1465                 1470             


Ser Gln  Arg Thr Asp Phe Val  Asp Pro Phe Ser Pro  Lys Ile Gln 
    1475                 1480                 1485             


Ala Lys  Ser Lys Ser Leu Arg  Gly Pro Arg Glu Lys  Ile Gln Arg 
    1490                 1495                 1500             


Leu Trp  Ser Gln Ser Val Ser  Leu Pro Arg Arg Leu  Met Arg Lys 
    1505                 1510                 1515             


Val Pro  Asn Arg Pro Glu Ile  Ile Asp Leu Gln Gln  Trp Gln Gly 
    1520                 1525                 1530             


Thr Arg  Gln Lys Ala Glu Asn  Glu Asn Thr Gly Ile  Cys Thr Asn 
    1535                 1540                 1545             


Lys Arg  Gly Ser Ser Asn Pro  Leu Leu Thr Thr Glu  Glu Ala Asn 
    1550                 1555                 1560             


Leu Thr  Glu Lys Glu Glu Ile  Arg Gln Gly Glu Thr  Leu Met Ile 
    1565                 1570                 1575             


Glu Gly  Thr Glu Gln Leu Lys  Ser Leu Ser Ser Asp  Ser Ser Phe 
    1580                 1585                 1590             


Cys Phe  Pro Arg Pro His Phe  Ser Phe Ser Thr Leu  Pro Thr Val 
    1595                 1600                 1605             


Ser Arg  Thr Val Glu Leu Lys  Ser Glu Pro Asn Val  Ile Ser Ser 
    1610                 1615                 1620             


Pro Ala  Glu Cys Ser Leu Glu  Leu Ser Pro Ser Arg  Pro Cys Val 
    1625                 1630                 1635             


Leu His  Ser Ser Leu Ser Arg  Arg Glu Thr Pro Ile  Cys Met Leu 
    1640                 1645                 1650             


Pro Ile  Glu Thr Glu Arg Asn  Ile Phe Glu Asn Phe  Ala His Pro 
    1655                 1660                 1665             


Pro Asn  Ile Ser Pro Ser Ala  Cys Pro Leu Pro Pro  Pro Pro Pro 
    1670                 1675                 1680             


Ile Ser  Pro Pro Ser Pro Pro  Pro Ala Pro Ala Pro  Leu Ala Pro 
    1685                 1690                 1695             


Pro Pro  Asp Ile Ser Pro Phe  Ser Leu Phe Cys Pro  Pro Pro Ser 
    1700                 1705                 1710             


Pro Pro  Ser Ile Pro Leu Pro  Leu Pro Pro Pro Thr  Phe Phe Pro 
    1715                 1720                 1725             


Leu Ser  Val Ser Thr Ser Gly  Pro Pro Thr Pro Pro  Leu Leu Pro 
    1730                 1735                 1740             


Pro Phe  Pro Thr Pro Leu Pro  Pro Pro Pro Pro Ser  Ile Pro Cys 
    1745                 1750                 1755             


Pro Pro  Pro Pro Ser Ala Ser  Phe Leu Ser Thr Glu  Cys Val Cys 
    1760                 1765                 1770             


Ile Thr  Gly Val Lys Cys Thr  Thr Asn Leu Met Pro  Ala Glu Lys 
    1775                 1780                 1785             


Ile Lys  Ser Ser Met Thr Gln  Leu Ser Thr Thr Thr  Val Cys Lys 
    1790                 1795                 1800             


Thr Asp  Pro Gln Arg Glu Pro  Lys Gly Ile Leu Arg  His Val Lys 
    1805                 1810                 1815             


Asn Leu  Ala Glu Leu Glu Lys  Ser Val Ala Asn Met  Tyr Ser Gln 
    1820                 1825                 1830             


Ile Glu  Lys Asn Tyr Leu Arg  Thr Asn Val Ser Glu  Leu Gln Thr 
    1835                 1840                 1845             


Met Cys  Pro Ser Glu Val Thr  Asn Met Glu Ile Thr  Ser Glu Gln 
    1850                 1855                 1860             


Asn Lys  Gly Ser Leu Asn Asn  Ile Val Glu Gly Thr  Glu Lys Gln 
    1865                 1870                 1875             


Ser His  Ser Gln Ser Thr Ser  Leu 
    1880                 1885     


<210>  1691
<211>  1952
<212>  PRT
<213>  Homo sapiens

<400>  1691

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Cys 
            20                  25                  30          


Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu 
        35                  40                  45              


Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly 
    50                  55                  60                  


Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn 
65                  70                  75                  80  


Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln Met Leu Phe Leu 
                85                  90                  95      


Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro Pro Met Asn Ile His 
            100                 105                 110         


Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys Lys Val Gly Thr Ile 
        115                 120                 125             


Ile Tyr His Glu Val Arg Ile Val Val Arg Asp Arg Asn Asp Asn Ser 
    130                 135                 140                 


Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr 
145                 150                 155                 160 


Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala 
                165                 170                 175     


Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln 
            180                 185                 190         


Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu 
        195                 200                 205             


Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp 
    210                 215                 220                 


Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn 
225                 230                 235                 240 


Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu Thr Val Asp Val Leu 
                245                 250                 255     


Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro Cys Val Leu Val Pro 
            260                 265                 270         


Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu 
        275                 280                 285             


Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile Val Thr Pro Pro Ile 
    290                 295                 300                 


Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro 
305                 310                 315                 320 


Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg 
                325                 330                 335     


Phe Phe His Met His Pro Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro 
            340                 345                 350         


Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu Val Ile Lys Ala Glu 
        355                 360                 365             


Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala Gly Leu His Ile Glu 
    370                 375                 380                 


Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr 
385                 390                 395                 400 


Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly Ala Thr Ile Ser Asp 
                405                 410                 415     


Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val Ala Leu Asp Lys Asp 
            420                 425                 430         


Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu Phe Leu Asn Asp Tyr 
        435                 440                 445             


Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr 
    450                 455                 460                 


Leu Leu Gln Pro Val Asp Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser 
465                 470                 475                 480 


Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu Pro Val Ile Val Asn 
                485                 490                 495     


Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile 
            500                 505                 510         


Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg Pro Gly Asp Ser Val 
        515                 520                 525             


Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile 
    530                 535                 540                 


Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys 
545                 550                 555                 560 


Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val Glu Met Ile Val Gly 
                565                 570                 575     


Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp Asn Ala Pro Pro Ala 
            580                 585                 590         


Glu Arg Arg Asn Ser Ile Cys Thr Val Tyr Ile Glu Val Leu Pro Pro 
        595                 600                 605             


Asn Asn Gln Ser Pro Pro Arg Phe Pro Gln Leu Met Tyr Ser Leu Glu 
    610                 615                 620                 


Ile Ser Glu Ala Met Arg Val Gly Ala Val Leu Leu Asn Leu Gln Ala 
625                 630                 635                 640 


Thr Asp Arg Glu Gly Asp Ser Ile Thr Tyr Ala Ile Glu Asn Gly Asp 
                645                 650                 655     


Pro Gln Arg Val Phe Asn Leu Ser Glu Thr Thr Gly Ile Leu Thr Leu 
            660                 665                 670         


Gly Lys Ala Leu Asp Arg Glu Ser Thr Asp Arg Tyr Ile Leu Ile Ile 
        675                 680                 685             


Thr Ala Ser Asp Gly Arg Pro Asp Gly Thr Ser Thr Ala Thr Val Asn 
    690                 695                 700                 


Ile Val Val Thr Asp Val Asn Asp Asn Ala Pro Val Phe Asp Pro Tyr 
705                 710                 715                 720 


Leu Pro Arg Asn Leu Ser Val Val Glu Glu Glu Ala Asn Ala Phe Val 
                725                 730                 735     


Gly Gln Val Lys Ala Thr Asp Pro Asp Ala Gly Ile Asn Gly Gln Val 
            740                 745                 750         


His Tyr Ser Leu Gly Asn Phe Asn Asn Leu Phe Arg Ile Thr Ser Asn 
        755                 760                 765             


Gly Ser Ile Tyr Thr Ala Val Lys Leu Asn Arg Glu Val Arg Asp Tyr 
    770                 775                 780                 


Tyr Glu Leu Val Val Val Ala Thr Asp Gly Ala Val His Pro Arg His 
785                 790                 795                 800 


Ser Thr Leu Thr Leu Ala Ile Lys Val Leu Asp Ile Asp Asp Asn Ser 
                805                 810                 815     


Pro Val Phe Thr Asn Ser Thr Tyr Thr Val Leu Val Glu Glu Asn Leu 
            820                 825                 830         


Pro Ala Gly Thr Thr Ile Leu Gln Ile Glu Ala Lys Asp Val Asp Leu 
        835                 840                 845             


Gly Ala Asn Val Ser Tyr Arg Ile Arg Ser Pro Glu Val Lys His Phe 
    850                 855                 860                 


Phe Ala Leu His Pro Phe Thr Gly Glu Leu Ser Leu Leu Arg Ser Leu 
865                 870                 875                 880 


Asp Tyr Glu Ala Phe Pro Asp Gln Glu Ala Ser Ile Thr Phe Leu Val 
                885                 890                 895     


Glu Ala Phe Asp Ile Tyr Gly Thr Met Pro Pro Gly Ile Ala Thr Val 
            900                 905                 910         


Thr Val Ile Val Lys Asp Met Asn Asp Tyr Pro Pro Val Phe Ser Lys 
        915                 920                 925             


Arg Ile Tyr Lys Gly Met Val Ala Pro Asp Ala Val Lys Gly Thr Pro 
    930                 935                 940                 


Ile Thr Thr Val Tyr Ala Glu Asp Ala Asp Pro Pro Gly Leu Pro Ala 
945                 950                 955                 960 


Ser Arg Val Arg Tyr Arg Val Asp Asp Val Gln Phe Pro Tyr Pro Ala 
                965                 970                 975     


Ser Ile Phe Glu Val Glu Glu Asp Ser Gly Arg Val Ile Thr Arg Val 
            980                 985                 990         


Asn Leu Asn Glu Glu Pro Thr Thr  Ile Phe Lys Leu Val  Val Val Ala 
        995                 1000                 1005             


Phe Asp  Asp Gly Glu Pro Val  Met Ser Ser Ser Ala  Thr Val Lys 
    1010                 1015                 1020             


Ile Leu  Val Leu His Pro Gly  Glu Ile Pro Arg Phe  Thr Gln Glu 
    1025                 1030                 1035             


Glu Tyr  Arg Pro Pro Pro Val  Ser Glu Leu Ala Thr  Lys Gly Thr 
    1040                 1045                 1050             


Met Val  Gly Val Ile Ser Ala  Ala Ala Ile Asn Gln  Ser Ile Val 
    1055                 1060                 1065             


Tyr Ser  Ile Val Ser Gly Asn  Glu Glu Asp Thr Phe  Gly Ile Asn 
    1070                 1075                 1080             


Asn Ile  Thr Gly Val Ile Tyr  Val Asn Gly Pro Leu  Asp Tyr Glu 
    1085                 1090                 1095             


Thr Arg  Thr Ser Tyr Val Leu  Arg Val Gln Ala Asp  Ser Leu Glu 
    1100                 1105                 1110             


Val Val  Leu Ala Asn Leu Arg  Val Pro Ser Lys Ser  Asn Thr Ala 
    1115                 1120                 1125             


Lys Val  Tyr Ile Glu Ile Gln  Asp Glu Asn Asn His  Pro Pro Val 
    1130                 1135                 1140             


Phe Gln  Lys Lys Phe Tyr Ile  Gly Gly Val Ser Glu  Asp Ala Arg 
    1145                 1150                 1155             


Met Phe  Thr Ser Val Leu Arg  Val Lys Ala Thr Asp  Lys Asp Thr 
    1160                 1165                 1170             


Gly Asn  Tyr Ser Val Met Ala  Tyr Arg Leu Ile Ile  Pro Pro Ile 
    1175                 1180                 1185             


Lys Glu  Gly Lys Glu Gly Phe  Val Val Glu Thr Tyr  Thr Gly Leu 
    1190                 1195                 1200             


Ile Lys  Thr Ala Met Leu Phe  His Asn Met Arg Arg  Ser Tyr Phe 
    1205                 1210                 1215             


Lys Phe  Gln Val Ile Ala Thr  Asp Asp Tyr Gly Lys  Gly Leu Ser 
    1220                 1225                 1230             


Gly Lys  Ala Asp Val Leu Val  Ser Val Val Asn Gln  Leu Asp Met 
    1235                 1240                 1245             


Gln Val  Ile Val Ser Asn Val  Pro Pro Thr Leu Val  Glu Lys Lys 
    1250                 1255                 1260             


Ile Glu  Asp Leu Thr Glu Ile  Leu Asp Arg Tyr Val  Gln Glu Gln 
    1265                 1270                 1275             


Ile Pro  Gly Ala Lys Val Val  Val Glu Ser Ile Gly  Ala Arg Arg 
    1280                 1285                 1290             


His Gly  Asp Ala Phe Ser Leu  Glu Asp Tyr Thr Lys  Cys Asp Leu 
    1295                 1300                 1305             


Thr Val  Tyr Ala Ile Asp Pro  Gln Thr Asn Arg Ala  Ile Asp Arg 
    1310                 1315                 1320             


Asn Glu  Leu Phe Lys Phe Leu  Asp Gly Lys Leu Leu  Asp Ile Asn 
    1325                 1330                 1335             


Lys Asp  Phe Gln Pro Tyr Tyr  Gly Glu Gly Gly Arg  Ile Leu Glu 
    1340                 1345                 1350             


Ile Arg  Thr Pro Glu Ala Val  Thr Ser Ile Lys Lys  Arg Gly Glu 
    1355                 1360                 1365             


Ser Leu  Gly Tyr Thr Glu Gly  Ala Leu Leu Ala Leu  Ala Phe Ile 
    1370                 1375                 1380             


Ile Ile  Leu Cys Cys Ile Pro  Ala Ile Leu Val Val  Leu Val Ser 
    1385                 1390                 1395             


Tyr Arg  Gln Arg Gln Ala Glu  Cys Thr Lys Thr Ala  Arg Ile Gln 
    1400                 1405                 1410             


Ala Ala  Leu Pro Ala Ala Lys  Pro Ala Val Pro Ala  Pro Ala Pro 
    1415                 1420                 1425             


Val Ala  Ala Pro Pro Pro Pro  Pro Pro Pro Pro Pro  Gly Ala His 
    1430                 1435                 1440             


Leu Tyr  Glu Glu Leu Gly Asp  Ser Ser Ile Leu Phe  Leu Leu Tyr 
    1445                 1450                 1455             


His Phe  Gln Gln Ser Arg Gly  Asn Asn Ser Val Ser  Glu Asp Arg 
    1460                 1465                 1470             


Lys His  Gln Gln Val Val Met  Pro Phe Ser Ser Asn  Thr Ile Glu 
    1475                 1480                 1485             


Ala His  Lys Ser Ala His Val  Asp Gly Ser Leu Lys  Ser Asn Lys 
    1490                 1495                 1500             


Leu Lys  Ser Ala Arg Lys Phe  Thr Phe Leu Ser Asp  Glu Asp Asp 
    1505                 1510                 1515             


Leu Ser  Ala His Asn Pro Leu  Tyr Lys Glu Asn Ile  Ser Gln Val 
    1520                 1525                 1530             


Ser Thr  Asn Ser Asp Ile Ser  Gln Arg Thr Asp Phe  Val Asp Pro 
    1535                 1540                 1545             


Phe Ser  Pro Lys Ile Gln Ala  Lys Ser Lys Ser Leu  Arg Gly Pro 
    1550                 1555                 1560             


Arg Glu  Lys Ile Gln Arg Leu  Trp Ser Gln Ser Val  Ser Leu Pro 
    1565                 1570                 1575             


Arg Arg  Leu Met Arg Lys Val  Pro Asn Arg Pro Glu  Ile Ile Asp 
    1580                 1585                 1590             


Leu Gln  Gln Trp Gln Gly Thr  Arg Gln Lys Ala Glu  Asn Glu Asn 
    1595                 1600                 1605             


Thr Gly  Ile Cys Thr Asn Lys  Arg Gly Ser Ser Asn  Pro Leu Leu 
    1610                 1615                 1620             


Thr Thr  Glu Glu Ala Asn Leu  Thr Glu Lys Glu Glu  Ile Arg Gln 
    1625                 1630                 1635             


Gly Glu  Thr Leu Met Ile Glu  Gly Thr Glu Gln Leu  Lys Ser Leu 
    1640                 1645                 1650             


Ser Ser  Asp Ser Ser Phe Cys  Phe Pro Arg Pro His  Phe Ser Phe 
    1655                 1660                 1665             


Ser Thr  Leu Pro Thr Val Ser  Arg Thr Val Glu Leu  Lys Ser Glu 
    1670                 1675                 1680             


Pro Asn  Val Ile Ser Ser Pro  Ala Glu Cys Ser Leu  Glu Leu Ser 
    1685                 1690                 1695             


Pro Ser  Arg Pro Cys Val Leu  His Ser Ser Leu Ser  Arg Arg Glu 
    1700                 1705                 1710             


Thr Pro  Ile Cys Met Leu Pro  Ile Glu Thr Glu Arg  Asn Ile Phe 
    1715                 1720                 1725             


Glu Asn  Phe Ala His Pro Pro  Asn Ile Ser Pro Ser  Ala Cys Pro 
    1730                 1735                 1740             


Leu Pro  Pro Pro Pro Pro Ile  Ser Pro Pro Ser Pro  Pro Pro Ala 
    1745                 1750                 1755             


Pro Ala  Pro Leu Ala Pro Pro  Pro Asp Ile Ser Pro  Phe Ser Leu 
    1760                 1765                 1770             


Phe Cys  Pro Pro Pro Ser Pro  Pro Ser Ile Pro Leu  Pro Leu Pro 
    1775                 1780                 1785             


Pro Pro  Thr Phe Phe Pro Leu  Ser Val Ser Thr Ser  Gly Pro Pro 
    1790                 1795                 1800             


Thr Pro  Pro Leu Leu Pro Pro  Phe Pro Thr Pro Leu  Pro Pro Pro 
    1805                 1810                 1815             


Pro Pro  Ser Ile Pro Cys Pro  Pro Pro Pro Ser Ala  Ser Phe Leu 
    1820                 1825                 1830             


Ser Thr  Glu Cys Val Cys Ile  Thr Gly Val Lys Cys  Thr Thr Asn 
    1835                 1840                 1845             


Leu Met  Pro Ala Glu Lys Ile  Lys Ser Ser Met Thr  Gln Leu Ser 
    1850                 1855                 1860             


Thr Thr  Thr Val Cys Lys Thr  Asp Pro Gln Arg Glu  Pro Lys Gly 
    1865                 1870                 1875             


Ile Leu  Arg His Val Lys Asn  Leu Ala Glu Leu Glu  Lys Ser Val 
    1880                 1885                 1890             


Ala Asn  Met Tyr Ser Gln Ile  Glu Lys Asn Tyr Leu  Arg Thr Asn 
    1895                 1900                 1905             


Val Ser  Glu Leu Gln Thr Met  Cys Pro Ser Glu Val  Thr Asn Met 
    1910                 1915                 1920             


Glu Ile  Thr Ser Glu Gln Asn  Lys Gly Ser Leu Asn  Asn Ile Val 
    1925                 1930                 1935             


Glu Gly  Thr Glu Lys Gln Ser  His Ser Gln Ser Thr  Ser Leu 
    1940                 1945                 1950         


<210>  1692
<211>  1915
<212>  PRT
<213>  Homo sapiens

<400>  1692

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Cys 
            20                  25                  30          


Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu 
        35                  40                  45              


Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly 
    50                  55                  60                  


Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn 
65                  70                  75                  80  


Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln Met Leu Phe Leu 
                85                  90                  95      


Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro Pro Met Asn Ile His 
            100                 105                 110         


Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys Lys Val Gly Thr Ile 
        115                 120                 125             


Ile Tyr His Glu Val Arg Ile Val Val Arg Asp Arg Asn Asp Asn Ser 
    130                 135                 140                 


Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr 
145                 150                 155                 160 


Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala 
                165                 170                 175     


Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln 
            180                 185                 190         


Tyr Asn Pro Asp Asp Pro Asp Arg Ala Gln Asn Leu Asn Glu Arg Arg 
        195                 200                 205             


Thr Thr Thr Thr Thr Leu Thr Val Asp Val Leu Asp Gly Asp Asp Leu 
    210                 215                 220                 


Gly Pro Met Phe Leu Pro Cys Val Leu Val Pro Asn Thr Arg Asp Cys 
225                 230                 235                 240 


Arg Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu Leu Arg Thr Pro Glu 
                245                 250                 255     


Glu Leu Asn Pro Ile Ile Val Thr Pro Pro Ile Gln Ala Ile Asp Gln 
            260                 265                 270         


Asp Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro Gly Ile Leu Tyr Ser 
        275                 280                 285             


Ile Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg Phe Phe His Met His 
    290                 295                 300                 


Pro Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro Val Asn Arg Asp Phe 
305                 310                 315                 320 


His Gln Lys Phe Asp Leu Val Ile Lys Ala Glu Gln Asp Asn Gly His 
                325                 330                 335     


Pro Leu Pro Ala Phe Ala Gly Leu His Ile Glu Ile Leu Asp Glu Asn 
            340                 345                 350         


Asn Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr Gln Gly Tyr Ile Leu 
        355                 360                 365             


Glu Ser Ala Pro Val Gly Ala Thr Ile Ser Asp Ser Leu Asn Leu Thr 
    370                 375                 380                 


Ser Pro Leu Arg Ile Val Ala Leu Asp Lys Asp Ile Glu Asp Thr Lys 
385                 390                 395                 400 


Asp Pro Glu Leu His Leu Phe Leu Asn Asp Tyr Thr Ser Val Phe Thr 
                405                 410                 415     


Val Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr Leu Leu Gln Pro Val 
            420                 425                 430         


Asp Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser Ile Thr Ala Phe Asp 
        435                 440                 445             


Gly Val Gln Glu Ser Glu Pro Val Ile Val Asn Ile Gln Val Met Asp 
    450                 455                 460                 


Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile Ser Tyr Asp Val Tyr 
465                 470                 475                 480 


Val Tyr Thr Asp Met Arg Pro Gly Asp Ser Val Ile Gln Leu Thr Ala 
                485                 490                 495     


Val Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile Thr Tyr Glu Ile Leu 
            500                 505                 510         


Val Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys Thr Thr Gly Leu Ile 
        515                 520                 525             


Thr Ile Ala Pro Gly Val Glu Met Ile Val Gly Arg Thr Tyr Ala Leu 
    530                 535                 540                 


Thr Val Gln Ala Ala Asp Asn Ala Pro Pro Ala Glu Arg Arg Asn Ser 
545                 550                 555                 560 


Ile Cys Thr Val Tyr Ile Glu Val Leu Pro Pro Asn Asn Gln Ser Pro 
                565                 570                 575     


Pro Arg Phe Pro Gln Leu Met Tyr Ser Leu Glu Ile Ser Glu Ala Met 
            580                 585                 590         


Arg Val Gly Ala Val Leu Leu Asn Leu Gln Ala Thr Asp Arg Glu Gly 
        595                 600                 605             


Asp Ser Ile Thr Tyr Ala Ile Glu Asn Gly Asp Pro Gln Arg Val Phe 
    610                 615                 620                 


Asn Leu Ser Glu Thr Thr Gly Ile Leu Thr Leu Gly Lys Ala Leu Asp 
625                 630                 635                 640 


Arg Glu Ser Thr Asp Arg Tyr Ile Leu Ile Ile Thr Ala Ser Asp Gly 
                645                 650                 655     


Arg Pro Asp Gly Thr Ser Thr Ala Thr Val Asn Ile Val Val Thr Asp 
            660                 665                 670         


Val Asn Asp Asn Ala Pro Val Phe Asp Pro Tyr Leu Pro Arg Asn Leu 
        675                 680                 685             


Ser Val Val Glu Glu Glu Ala Asn Ala Phe Val Gly Gln Val Lys Ala 
    690                 695                 700                 


Thr Asp Pro Asp Ala Gly Ile Asn Gly Gln Val His Tyr Ser Leu Gly 
705                 710                 715                 720 


Asn Phe Asn Asn Leu Phe Arg Ile Thr Ser Asn Gly Ser Ile Tyr Thr 
                725                 730                 735     


Ala Val Lys Leu Asn Arg Glu Val Arg Asp Tyr Tyr Glu Leu Val Val 
            740                 745                 750         


Val Ala Thr Asp Gly Ala Val His Pro Arg His Ser Thr Leu Thr Leu 
        755                 760                 765             


Ala Ile Lys Val Leu Asp Ile Asp Asp Asn Ser Pro Val Phe Thr Asn 
    770                 775                 780                 


Ser Thr Tyr Thr Val Leu Val Glu Glu Asn Leu Pro Ala Gly Thr Thr 
785                 790                 795                 800 


Ile Leu Gln Ile Glu Ala Lys Asp Val Asp Leu Gly Ala Asn Val Ser 
                805                 810                 815     


Tyr Arg Ile Arg Ser Pro Glu Val Lys His Phe Phe Ala Leu His Pro 
            820                 825                 830         


Phe Thr Gly Glu Leu Ser Leu Leu Arg Ser Leu Asp Tyr Glu Ala Phe 
        835                 840                 845             


Pro Asp Gln Glu Ala Ser Ile Thr Phe Leu Val Glu Ala Phe Asp Ile 
    850                 855                 860                 


Tyr Gly Thr Met Pro Pro Gly Ile Ala Thr Val Thr Val Ile Val Lys 
865                 870                 875                 880 


Asp Met Asn Asp Tyr Pro Pro Val Phe Ser Lys Arg Ile Tyr Lys Gly 
                885                 890                 895     


Met Val Ala Pro Asp Ala Val Lys Gly Thr Pro Ile Thr Thr Val Tyr 
            900                 905                 910         


Ala Glu Asp Ala Asp Pro Pro Gly Leu Pro Ala Ser Arg Val Arg Tyr 
        915                 920                 925             


Arg Val Asp Asp Val Gln Phe Pro Tyr Pro Ala Ser Ile Phe Glu Val 
    930                 935                 940                 


Glu Glu Asp Ser Gly Arg Val Ile Thr Arg Val Asn Leu Asn Glu Glu 
945                 950                 955                 960 


Pro Thr Thr Ile Phe Lys Leu Val Val Val Ala Phe Asp Asp Gly Glu 
                965                 970                 975     


Pro Val Met Ser Ser Ser Ala Thr Val Lys Ile Leu Val Leu His Pro 
            980                 985                 990         


Gly Glu Ile Pro Arg Phe Thr Gln  Glu Glu Tyr Arg Pro  Pro Pro Val 
        995                 1000                 1005             


Ser Glu  Leu Ala Thr Lys Gly  Thr Met Val Gly Val  Ile Ser Ala 
    1010                 1015                 1020             


Ala Ala  Ile Asn Gln Ser Ile  Val Tyr Ser Ile Val  Ser Gly Asn 
    1025                 1030                 1035             


Glu Glu  Asp Thr Phe Gly Ile  Asn Asn Ile Thr Gly  Val Ile Tyr 
    1040                 1045                 1050             


Val Asn  Gly Pro Leu Asp Tyr  Glu Thr Arg Thr Ser  Tyr Val Leu 
    1055                 1060                 1065             


Arg Val  Gln Ala Asp Ser Leu  Glu Val Val Leu Ala  Asn Leu Arg 
    1070                 1075                 1080             


Val Pro  Ser Lys Ser Asn Thr  Ala Lys Val Tyr Ile  Glu Ile Gln 
    1085                 1090                 1095             


Asp Glu  Asn Asn His Pro Pro  Val Phe Gln Lys Lys  Phe Tyr Ile 
    1100                 1105                 1110             


Gly Gly  Val Ser Glu Asp Ala  Arg Met Phe Thr Ser  Val Leu Arg 
    1115                 1120                 1125             


Val Lys  Ala Thr Asp Lys Asp  Thr Gly Asn Tyr Ser  Val Met Ala 
    1130                 1135                 1140             


Tyr Arg  Leu Ile Ile Pro Pro  Ile Lys Glu Gly Lys  Glu Gly Phe 
    1145                 1150                 1155             


Val Val  Glu Thr Tyr Thr Gly  Leu Ile Lys Thr Ala  Met Leu Phe 
    1160                 1165                 1170             


His Asn  Met Arg Arg Ser Tyr  Phe Lys Phe Gln Val  Ile Ala Thr 
    1175                 1180                 1185             


Asp Asp  Tyr Gly Lys Gly Leu  Ser Gly Lys Ala Asp  Val Leu Val 
    1190                 1195                 1200             


Ser Val  Val Asn Gln Leu Asp  Met Gln Val Ile Val  Ser Asn Val 
    1205                 1210                 1215             


Pro Pro  Thr Leu Val Glu Lys  Lys Ile Glu Asp Leu  Thr Glu Ile 
    1220                 1225                 1230             


Leu Asp  Arg Tyr Val Gln Glu  Gln Ile Pro Gly Ala  Lys Val Val 
    1235                 1240                 1245             


Val Glu  Ser Ile Gly Ala Arg  Arg His Gly Asp Ala  Phe Ser Leu 
    1250                 1255                 1260             


Glu Asp  Tyr Thr Lys Cys Asp  Leu Thr Val Tyr Ala  Ile Asp Pro 
    1265                 1270                 1275             


Gln Thr  Asn Arg Ala Ile Asp  Arg Asn Glu Leu Phe  Lys Phe Leu 
    1280                 1285                 1290             


Asp Gly  Lys Leu Leu Asp Ile  Asn Lys Asp Phe Gln  Pro Tyr Tyr 
    1295                 1300                 1305             


Gly Glu  Gly Gly Arg Ile Leu  Glu Ile Arg Thr Pro  Glu Ala Val 
    1310                 1315                 1320             


Thr Ser  Ile Lys Lys Arg Gly  Glu Ser Leu Gly Tyr  Thr Glu Gly 
    1325                 1330                 1335             


Ala Leu  Leu Ala Leu Ala Phe  Ile Ile Ile Leu Cys  Cys Ile Pro 
    1340                 1345                 1350             


Ala Ile  Leu Val Val Leu Val  Ser Tyr Arg Gln Arg  Gln Ala Glu 
    1355                 1360                 1365             


Cys Thr  Lys Thr Ala Arg Ile  Gln Ala Ala Leu Pro  Ala Ala Lys 
    1370                 1375                 1380             


Pro Ala  Val Pro Ala Pro Ala  Pro Val Ala Ala Pro  Pro Pro Pro 
    1385                 1390                 1395             


Pro Pro  Pro Pro Pro Gly Ala  His Leu Tyr Glu Glu  Leu Gly Asp 
    1400                 1405                 1410             


Ser Ser  Ile Leu Phe Leu Leu  Tyr His Phe Gln Gln  Ser Arg Gly 
    1415                 1420                 1425             


Asn Asn  Ser Val Ser Glu Asp  Arg Lys His Gln Gln  Val Val Met 
    1430                 1435                 1440             


Pro Phe  Ser Ser Asn Thr Ile  Glu Ala His Lys Ser  Ala His Val 
    1445                 1450                 1455             


Asp Gly  Ser Leu Lys Ser Asn  Lys Leu Lys Ser Ala  Arg Lys Phe 
    1460                 1465                 1470             


Thr Phe  Leu Ser Asp Glu Asp  Asp Leu Ser Ala His  Asn Pro Leu 
    1475                 1480                 1485             


Tyr Lys  Glu Asn Ile Ser Gln  Val Ser Thr Asn Ser  Asp Ile Ser 
    1490                 1495                 1500             


Gln Arg  Thr Asp Phe Val Asp  Pro Phe Ser Pro Lys  Ile Gln Ala 
    1505                 1510                 1515             


Lys Ser  Lys Ser Leu Arg Gly  Pro Arg Glu Lys Ile  Gln Arg Leu 
    1520                 1525                 1530             


Trp Ser  Gln Ser Val Ser Leu  Pro Arg Arg Leu Met  Arg Lys Val 
    1535                 1540                 1545             


Pro Asn  Arg Pro Glu Ile Ile  Asp Leu Gln Gln Trp  Gln Gly Thr 
    1550                 1555                 1560             


Arg Gln  Lys Ala Glu Asn Glu  Asn Thr Gly Ile Cys  Thr Asn Lys 
    1565                 1570                 1575             


Arg Gly  Ser Ser Asn Pro Leu  Leu Thr Thr Glu Glu  Ala Asn Leu 
    1580                 1585                 1590             


Thr Glu  Lys Glu Glu Ile Arg  Gln Gly Glu Thr Leu  Met Ile Glu 
    1595                 1600                 1605             


Gly Thr  Glu Gln Leu Lys Ser  Leu Ser Ser Asp Ser  Ser Phe Cys 
    1610                 1615                 1620             


Phe Pro  Arg Pro His Phe Ser  Phe Ser Thr Leu Pro  Thr Val Ser 
    1625                 1630                 1635             


Arg Thr  Val Glu Leu Lys Ser  Glu Pro Asn Val Ile  Ser Ser Pro 
    1640                 1645                 1650             


Ala Glu  Cys Ser Leu Glu Leu  Ser Pro Ser Arg Pro  Cys Val Leu 
    1655                 1660                 1665             


His Ser  Ser Leu Ser Arg Arg  Glu Thr Pro Ile Cys  Met Leu Pro 
    1670                 1675                 1680             


Ile Glu  Thr Glu Arg Asn Ile  Phe Glu Asn Phe Ala  His Pro Pro 
    1685                 1690                 1695             


Asn Ile  Ser Pro Ser Ala Cys  Pro Leu Pro Pro Pro  Pro Pro Ile 
    1700                 1705                 1710             


Ser Pro  Pro Ser Pro Pro Pro  Ala Pro Ala Pro Leu  Ala Pro Pro 
    1715                 1720                 1725             


Pro Asp  Ile Ser Pro Phe Ser  Leu Phe Cys Pro Pro  Pro Ser Pro 
    1730                 1735                 1740             


Pro Ser  Ile Pro Leu Pro Leu  Pro Pro Pro Thr Phe  Phe Pro Leu 
    1745                 1750                 1755             


Ser Val  Ser Thr Ser Gly Pro  Pro Thr Pro Pro Leu  Leu Pro Pro 
    1760                 1765                 1770             


Phe Pro  Thr Pro Leu Pro Pro  Pro Pro Pro Ser Ile  Pro Cys Pro 
    1775                 1780                 1785             


Pro Pro  Pro Ser Ala Ser Phe  Leu Ser Thr Glu Cys  Val Cys Ile 
    1790                 1795                 1800             


Thr Gly  Val Lys Cys Thr Thr  Asn Leu Met Pro Ala  Glu Lys Ile 
    1805                 1810                 1815             


Lys Ser  Ser Met Thr Gln Leu  Ser Thr Thr Thr Val  Cys Lys Thr 
    1820                 1825                 1830             


Asp Pro  Gln Arg Glu Pro Lys  Gly Ile Leu Arg His  Val Lys Asn 
    1835                 1840                 1845             


Leu Ala  Glu Leu Glu Lys Ser  Val Ala Asn Met Tyr  Ser Gln Ile 
    1850                 1855                 1860             


Glu Lys  Asn Tyr Leu Arg Thr  Asn Val Ser Glu Leu  Gln Thr Met 
    1865                 1870                 1875             


Cys Pro  Ser Glu Val Thr Asn  Met Glu Ile Thr Ser  Glu Gln Asn 
    1880                 1885                 1890             


Lys Gly  Ser Leu Asn Asn Ile  Val Glu Gly Thr Glu  Lys Gln Ser 
    1895                 1900                 1905             


His Ser  Gln Ser Thr Ser Leu  
    1910                 1915 


<210>  1693
<211>  1935
<212>  PRT
<213>  Homo sapiens

<400>  1693

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Gly Thr 
            20                  25                  30          


Ile Leu Val Asp Asn Met Leu Ile Lys Gly Thr Ala Gly Gly Pro Asp 
        35                  40                  45              


Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn Val Asp Tyr Trp Val Leu 
    50                  55                  60                  


Met Asp Pro Val Lys Gln Met Leu Phe Leu Asn Ser Thr Gly Arg Val 
65                  70                  75                  80  


Leu Asp Arg Asp Pro Pro Met Asn Ile His Ser Ile Val Val Gln Val 
                85                  90                  95      


Gln Cys Ile Asn Lys Lys Val Gly Thr Ile Ile Tyr His Glu Val Arg 
            100                 105                 110         


Ile Val Val Arg Asp Arg Asn Asp Asn Ser Pro Thr Phe Lys His Glu 
        115                 120                 125             


Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr Pro Val Gly Thr Thr Ile 
    130                 135                 140                 


Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala Thr Asp Ile Asp Asp Gly 
145                 150                 155                 160 


Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln Tyr Asn Pro Asp Asp Pro 
                165                 170                 175     


Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu Met Leu Thr Gly Asn Ile 
            180                 185                 190         


Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp Lys Thr Arg Tyr Phe Val 
        195                 200                 205             


Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn Leu Asn Glu Arg Arg Thr 
    210                 215                 220                 


Thr Thr Thr Thr Leu Thr Val Asp Val Leu Asp Gly Asp Asp Leu Gly 
225                 230                 235                 240 


Pro Met Phe Leu Pro Cys Val Leu Val Pro Asn Thr Arg Asp Cys Arg 
                245                 250                 255     


Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu Leu Arg Thr Pro Glu Glu 
            260                 265                 270         


Leu Asn Pro Ile Ile Val Thr Pro Pro Ile Gln Ala Ile Asp Gln Asp 
        275                 280                 285             


Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro Gly Ile Leu Tyr Ser Ile 
    290                 295                 300                 


Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg Phe Phe His Met His Pro 
305                 310                 315                 320 


Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro Val Asn Arg Asp Phe His 
                325                 330                 335     


Gln Lys Phe Asp Leu Val Ile Lys Ala Glu Gln Asp Asn Gly His Pro 
            340                 345                 350         


Leu Pro Ala Phe Ala Gly Leu His Ile Glu Ile Leu Asp Glu Asn Asn 
        355                 360                 365             


Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr Gln Gly Tyr Ile Leu Glu 
    370                 375                 380                 


Ser Ala Pro Val Gly Ala Thr Ile Ser Asp Ser Leu Asn Leu Thr Ser 
385                 390                 395                 400 


Pro Leu Arg Ile Val Ala Leu Asp Lys Asp Ile Glu Asp Thr Lys Asp 
                405                 410                 415     


Pro Glu Leu His Leu Phe Leu Asn Asp Tyr Thr Ser Val Phe Thr Val 
            420                 425                 430         


Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr Leu Leu Gln Pro Val Asp 
        435                 440                 445             


Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser Ile Thr Ala Phe Asp Gly 
    450                 455                 460                 


Val Gln Glu Ser Glu Pro Val Ile Val Asn Ile Gln Val Met Asp Ala 
465                 470                 475                 480 


Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile Ser Tyr Asp Val Tyr Val 
                485                 490                 495     


Tyr Thr Asp Met Arg Pro Gly Asp Ser Val Ile Gln Leu Thr Ala Val 
            500                 505                 510         


Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile Thr Tyr Glu Ile Leu Val 
        515                 520                 525             


Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys Thr Thr Gly Leu Ile Thr 
    530                 535                 540                 


Ile Ala Pro Gly Val Glu Met Ile Val Gly Arg Thr Tyr Ala Leu Thr 
545                 550                 555                 560 


Val Gln Ala Ala Asp Asn Ala Pro Pro Ala Glu Arg Arg Asn Ser Ile 
                565                 570                 575     


Cys Thr Val Tyr Ile Glu Val Leu Pro Pro Asn Asn Gln Ser Pro Pro 
            580                 585                 590         


Arg Phe Pro Gln Leu Met Tyr Ser Leu Glu Ile Ser Glu Ala Met Arg 
        595                 600                 605             


Val Gly Ala Val Leu Leu Asn Leu Gln Ala Thr Asp Arg Glu Gly Asp 
    610                 615                 620                 


Ser Ile Thr Tyr Ala Ile Glu Asn Gly Asp Pro Gln Arg Val Phe Asn 
625                 630                 635                 640 


Leu Ser Glu Thr Thr Gly Ile Leu Thr Leu Gly Lys Ala Leu Asp Arg 
                645                 650                 655     


Glu Ser Thr Asp Arg Tyr Ile Leu Ile Ile Thr Ala Ser Asp Gly Arg 
            660                 665                 670         


Pro Asp Gly Thr Ser Thr Ala Thr Val Asn Ile Val Val Thr Asp Val 
        675                 680                 685             


Asn Asp Asn Ala Pro Val Phe Asp Pro Tyr Leu Pro Arg Asn Leu Ser 
    690                 695                 700                 


Val Val Glu Glu Glu Ala Asn Ala Phe Val Gly Gln Val Lys Ala Thr 
705                 710                 715                 720 


Asp Pro Asp Ala Gly Ile Asn Gly Gln Val His Tyr Ser Leu Gly Asn 
                725                 730                 735     


Phe Asn Asn Leu Phe Arg Ile Thr Ser Asn Gly Ser Ile Tyr Thr Ala 
            740                 745                 750         


Val Lys Leu Asn Arg Glu Val Arg Asp Tyr Tyr Glu Leu Val Val Val 
        755                 760                 765             


Ala Thr Asp Gly Ala Val His Pro Arg His Ser Thr Leu Thr Leu Ala 
    770                 775                 780                 


Ile Lys Val Leu Asp Ile Asp Asp Asn Ser Pro Val Phe Thr Asn Ser 
785                 790                 795                 800 


Thr Tyr Thr Val Leu Val Glu Glu Asn Leu Pro Ala Gly Thr Thr Ile 
                805                 810                 815     


Leu Gln Ile Glu Ala Lys Asp Val Asp Leu Gly Ala Asn Val Ser Tyr 
            820                 825                 830         


Arg Ile Arg Ser Pro Glu Val Lys His Phe Phe Ala Leu His Pro Phe 
        835                 840                 845             


Thr Gly Glu Leu Ser Leu Leu Arg Ser Leu Asp Tyr Glu Ala Phe Pro 
    850                 855                 860                 


Asp Gln Glu Ala Ser Ile Thr Phe Leu Val Glu Ala Phe Asp Ile Tyr 
865                 870                 875                 880 


Gly Thr Met Pro Pro Gly Ile Ala Thr Val Thr Val Ile Val Lys Asp 
                885                 890                 895     


Met Asn Asp Tyr Pro Pro Val Phe Ser Lys Arg Ile Tyr Lys Gly Met 
            900                 905                 910         


Val Ala Pro Asp Ala Val Lys Gly Thr Pro Ile Thr Thr Val Tyr Ala 
        915                 920                 925             


Glu Asp Ala Asp Pro Pro Gly Leu Pro Ala Ser Arg Val Arg Tyr Arg 
    930                 935                 940                 


Val Asp Asp Val Gln Phe Pro Tyr Pro Ala Ser Ile Phe Glu Val Glu 
945                 950                 955                 960 


Glu Asp Ser Gly Arg Val Ile Thr Arg Val Asn Leu Asn Glu Glu Pro 
                965                 970                 975     


Thr Thr Ile Phe Lys Leu Val Val Val Ala Phe Asp Asp Gly Glu Pro 
            980                 985                 990         


Val Met Ser Ser Ser Ala Thr Val  Lys Ile Leu Val Leu  His Pro Gly 
        995                 1000                 1005             


Glu Ile  Pro Arg Phe Thr Gln  Glu Glu Tyr Arg Pro  Pro Pro Val 
    1010                 1015                 1020             


Ser Glu  Leu Ala Thr Lys Gly  Thr Met Val Gly Val  Ile Ser Ala 
    1025                 1030                 1035             


Ala Ala  Ile Asn Gln Ser Ile  Val Tyr Ser Ile Val  Ser Gly Asn 
    1040                 1045                 1050             


Glu Glu  Asp Thr Phe Gly Ile  Asn Asn Ile Thr Gly  Val Ile Tyr 
    1055                 1060                 1065             


Val Asn  Gly Pro Leu Asp Tyr  Glu Thr Arg Thr Ser  Tyr Val Leu 
    1070                 1075                 1080             


Arg Val  Gln Ala Asp Ser Leu  Glu Val Val Leu Ala  Asn Leu Arg 
    1085                 1090                 1095             


Val Pro  Ser Lys Ser Asn Thr  Ala Lys Val Tyr Ile  Glu Ile Gln 
    1100                 1105                 1110             


Asp Glu  Asn Asn His Pro Pro  Val Phe Gln Lys Lys  Phe Tyr Ile 
    1115                 1120                 1125             


Gly Gly  Val Ser Glu Asp Ala  Arg Met Phe Thr Ser  Val Leu Arg 
    1130                 1135                 1140             


Val Lys  Ala Thr Asp Lys Asp  Thr Gly Asn Tyr Ser  Val Met Ala 
    1145                 1150                 1155             


Tyr Arg  Leu Ile Ile Pro Pro  Ile Lys Glu Gly Lys  Glu Gly Phe 
    1160                 1165                 1170             


Val Val  Glu Thr Tyr Thr Gly  Leu Ile Lys Thr Ala  Met Leu Phe 
    1175                 1180                 1185             


His Asn  Met Arg Arg Ser Tyr  Phe Lys Phe Gln Val  Ile Ala Thr 
    1190                 1195                 1200             


Asp Asp  Tyr Gly Lys Gly Leu  Ser Gly Lys Ala Asp  Val Leu Val 
    1205                 1210                 1215             


Ser Val  Val Asn Gln Leu Asp  Met Gln Val Ile Val  Ser Asn Val 
    1220                 1225                 1230             


Pro Pro  Thr Leu Val Glu Lys  Lys Ile Glu Asp Leu  Thr Glu Ile 
    1235                 1240                 1245             


Leu Asp  Arg Tyr Val Gln Glu  Gln Ile Pro Gly Ala  Lys Val Val 
    1250                 1255                 1260             


Val Glu  Ser Ile Gly Ala Arg  Arg His Gly Asp Ala  Phe Ser Leu 
    1265                 1270                 1275             


Glu Asp  Tyr Thr Lys Cys Asp  Leu Thr Val Tyr Ala  Ile Asp Pro 
    1280                 1285                 1290             


Gln Thr  Asn Arg Ala Ile Asp  Arg Asn Glu Leu Phe  Lys Phe Leu 
    1295                 1300                 1305             


Asp Gly  Lys Leu Leu Asp Ile  Asn Lys Asp Phe Gln  Pro Tyr Tyr 
    1310                 1315                 1320             


Gly Glu  Gly Gly Arg Ile Leu  Glu Ile Arg Thr Pro  Glu Ala Val 
    1325                 1330                 1335             


Thr Ser  Ile Lys Lys Arg Gly  Glu Ser Leu Gly Tyr  Thr Glu Gly 
    1340                 1345                 1350             


Ala Leu  Leu Ala Leu Ala Phe  Ile Ile Ile Leu Cys  Cys Ile Pro 
    1355                 1360                 1365             


Ala Ile  Leu Val Val Leu Val  Ser Tyr Arg Gln Phe  Lys Val Arg 
    1370                 1375                 1380             


Gln Ala  Glu Cys Thr Lys Thr  Ala Arg Ile Gln Ala  Ala Leu Pro 
    1385                 1390                 1395             


Ala Ala  Lys Pro Ala Val Pro  Ala Pro Ala Pro Val  Ala Ala Pro 
    1400                 1405                 1410             


Pro Pro  Pro Pro Pro Pro Pro  Pro Gly Ala His Leu  Tyr Glu Glu 
    1415                 1420                 1425             


Leu Gly  Asp Ser Ser Met His  Asn Leu Phe Leu Leu  Tyr His Phe 
    1430                 1435                 1440             


Gln Gln  Ser Arg Gly Asn Asn  Ser Val Ser Glu Asp  Arg Lys His 
    1445                 1450                 1455             


Gln Gln  Val Val Met Pro Phe  Ser Ser Asn Thr Ile  Glu Ala His 
    1460                 1465                 1470             


Lys Ser  Ala His Val Asp Gly  Ser Leu Lys Ser Asn  Lys Leu Lys 
    1475                 1480                 1485             


Ser Ala  Arg Lys Phe Thr Phe  Leu Ser Asp Glu Asp  Asp Leu Ser 
    1490                 1495                 1500             


Ala His  Asn Pro Leu Tyr Lys  Glu Asn Ile Ser Gln  Val Ser Thr 
    1505                 1510                 1515             


Asn Ser  Asp Ile Ser Gln Arg  Thr Asp Phe Val Asp  Pro Phe Ser 
    1520                 1525                 1530             


Pro Lys  Ile Gln Ala Lys Ser  Lys Ser Leu Arg Gly  Pro Arg Glu 
    1535                 1540                 1545             


Lys Ile  Gln Arg Leu Trp Ser  Gln Ser Val Ser Leu  Pro Arg Arg 
    1550                 1555                 1560             


Leu Met  Arg Lys Val Pro Asn  Arg Pro Glu Ile Ile  Asp Leu Gln 
    1565                 1570                 1575             


Gln Trp  Gln Gly Thr Arg Gln  Lys Ala Glu Asn Glu  Asn Thr Gly 
    1580                 1585                 1590             


Ile Cys  Thr Asn Lys Arg Gly  Ser Ser Asn Pro Leu  Leu Thr Thr 
    1595                 1600                 1605             


Glu Glu  Ala Asn Leu Thr Glu  Lys Glu Glu Ile Arg  Gln Gly Glu 
    1610                 1615                 1620             


Thr Leu  Met Ile Glu Gly Thr  Glu Gln Leu Lys Ser  Leu Ser Ser 
    1625                 1630                 1635             


Asp Ser  Ser Phe Cys Phe Pro  Arg Pro His Phe Ser  Phe Ser Thr 
    1640                 1645                 1650             


Leu Pro  Thr Val Ser Arg Thr  Val Glu Leu Lys Ser  Glu Pro Asn 
    1655                 1660                 1665             


Val Ile  Ser Ser Pro Ala Glu  Cys Ser Leu Glu Leu  Ser Pro Ser 
    1670                 1675                 1680             


Arg Pro  Cys Val Leu His Ser  Ser Leu Ser Arg Arg  Glu Thr Pro 
    1685                 1690                 1695             


Ile Cys  Met Leu Pro Ile Glu  Thr Glu Arg Asn Ile  Phe Glu Asn 
    1700                 1705                 1710             


Phe Ala  His Pro Pro Asn Ile  Ser Pro Ser Ala Cys  Pro Leu Pro 
    1715                 1720                 1725             


Pro Pro  Pro Pro Ile Ser Pro  Pro Ser Pro Pro Pro  Ala Pro Ala 
    1730                 1735                 1740             


Pro Leu  Ala Pro Pro Pro Asp  Ile Ser Pro Phe Ser  Leu Phe Cys 
    1745                 1750                 1755             


Pro Pro  Pro Ser Pro Pro Ser  Ile Pro Leu Pro Leu  Pro Pro Pro 
    1760                 1765                 1770             


Thr Phe  Phe Pro Leu Ser Val  Ser Thr Ser Gly Pro  Pro Thr Pro 
    1775                 1780                 1785             


Pro Leu  Leu Pro Pro Phe Pro  Thr Pro Leu Pro Pro  Pro Pro Pro 
    1790                 1795                 1800             


Ser Ile  Pro Cys Pro Pro Pro  Pro Ser Ala Ser Phe  Leu Ser Thr 
    1805                 1810                 1815             


Glu Cys  Val Cys Ile Thr Gly  Val Lys Cys Thr Thr  Asn Leu Met 
    1820                 1825                 1830             


Pro Ala  Glu Lys Ile Lys Ser  Ser Met Thr Gln Leu  Ser Thr Thr 
    1835                 1840                 1845             


Thr Val  Cys Lys Thr Asp Pro  Gln Arg Glu Pro Lys  Gly Ile Leu 
    1850                 1855                 1860             


Arg His  Val Lys Asn Leu Ala  Glu Leu Glu Lys Ser  Val Ala Asn 
    1865                 1870                 1875             


Met Tyr  Ser Gln Ile Glu Lys  Asn Tyr Leu Arg Thr  Asn Val Ser 
    1880                 1885                 1890             


Glu Leu  Gln Thr Met Cys Pro  Ser Glu Val Thr Asn  Met Glu Ile 
    1895                 1900                 1905             


Thr Ser  Glu Gln Asn Lys Gly  Ser Leu Asn Asn Ile  Val Glu Gly 
    1910                 1915                 1920             


Thr Glu  Lys Gln Ser His Ser  Gln Ser Thr Ser Leu  
    1925                 1930                 1935 


<210>  1694
<211>  1790
<212>  PRT
<213>  Homo sapiens

<400>  1694

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Trp 
            20                  25                  30          


Gln Tyr Glu Asp Cys Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile 
        35                  40                  45              


Val Ala Ile Asp Glu Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn 
    50                  55                  60                  


Met Leu Ile Lys Gly Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu 
65                  70                  75                  80  


Ser Leu Lys Asp Asn Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys 
                85                  90                  95      


Gln Met Leu Phe Leu Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro 
            100                 105                 110         


Pro Met Asn Ile His Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys 
        115                 120                 125             


Lys Val Gly Thr Ile Ile Tyr His Glu Val Arg Ile Val Val Arg Asp 
    130                 135                 140                 


Arg Asn Asp Asn Ser Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr 
145                 150                 155                 160 


Val Asn Glu Leu Thr Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser 
                165                 170                 175     


Gly Asp Asn Gly Ala Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile 
            180                 185                 190         


Glu Tyr Val Ile Gln Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr 
        195                 200                 205             


Phe Glu Ile Pro Leu Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg 
    210                 215                 220                 


Leu Asn Tyr Glu Asp Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn 
225                 230                 235                 240 


Asp Arg Ala Gln Asn Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu 
                245                 250                 255     


Thr Val Asp Val Leu Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro 
            260                 265                 270         


Cys Val Leu Val Pro Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln 
        275                 280                 285             


Ala Ala Ile Pro Glu Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile 
    290                 295                 300                 


Val Thr Pro Pro Ile Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro 
305                 310                 315                 320 


Pro Ser Asp Arg Pro Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro 
                325                 330                 335     


Glu Asp Tyr Pro Arg Phe Phe His Met His Pro Arg Thr Ala Glu Leu 
            340                 345                 350         


Ser Leu Leu Glu Pro Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu 
        355                 360                 365             


Val Ile Lys Ala Glu Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala 
    370                 375                 380                 


Gly Leu His Ile Glu Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe 
385                 390                 395                 400 


Thr Met Pro Ser Tyr Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly 
                405                 410                 415     


Ala Thr Ile Ser Asp Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val 
            420                 425                 430         


Ala Leu Asp Lys Asp Ile Glu Asp Val Pro Pro Ser Gly Val Pro Thr 
        435                 440                 445             


Lys Asp Pro Glu Leu His Leu Phe Leu Asn Asp Tyr Thr Ser Val Phe 
    450                 455                 460                 


Thr Val Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr Leu Leu Gln Pro 
465                 470                 475                 480 


Val Asp Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser Ile Thr Ala Phe 
                485                 490                 495     


Asp Gly Val Gln Glu Ser Glu Pro Val Ile Val Asn Ile Gln Val Met 
            500                 505                 510         


Asp Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile Ser Tyr Asp Val 
        515                 520                 525             


Tyr Val Tyr Thr Asp Met Arg Pro Gly Asp Ser Val Ile Gln Leu Thr 
    530                 535                 540                 


Ala Val Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile Thr Tyr Glu Ile 
545                 550                 555                 560 


Leu Val Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys Thr Thr Gly Leu 
                565                 570                 575     


Ile Thr Ile Ala Pro Gly Val Glu Met Ile Val Gly Arg Thr Tyr Ala 
            580                 585                 590         


Leu Thr Val Gln Ala Ala Asp Asn Ala Pro Pro Ala Glu Arg Arg Asn 
        595                 600                 605             


Ser Ile Cys Thr Val Tyr Ile Glu Val Leu Pro Pro Asn Asn Gln Ser 
    610                 615                 620                 


Pro Pro Arg Phe Pro Gln Leu Met Tyr Ser Leu Glu Ile Ser Glu Ala 
625                 630                 635                 640 


Met Arg Val Gly Ala Val Leu Leu Asn Leu Gln Ala Thr Asp Arg Glu 
                645                 650                 655     


Gly Asp Ser Ile Thr Tyr Ala Ile Glu Asn Gly Asp Pro Gln Arg Val 
            660                 665                 670         


Phe Asn Leu Ser Glu Thr Thr Gly Ile Leu Thr Leu Gly Lys Ala Leu 
        675                 680                 685             


Asp Arg Glu Ser Thr Asp Arg Tyr Ile Leu Ile Ile Thr Ala Ser Asp 
    690                 695                 700                 


Gly Arg Pro Asp Gly Thr Ser Thr Ala Thr Val Asn Ile Val Val Thr 
705                 710                 715                 720 


Asp Val Asn Asp Asn Ala Pro Val Phe Asp Pro Tyr Leu Pro Arg Asn 
                725                 730                 735     


Leu Ser Val Val Glu Glu Glu Ala Asn Ala Phe Val Gly Gln Val Lys 
            740                 745                 750         


Ala Thr Asp Pro Asp Ala Gly Ile Asn Gly Gln Val His Tyr Ser Leu 
        755                 760                 765             


Gly Asn Phe Asn Asn Leu Phe Arg Ile Thr Ser Asn Gly Ser Ile Tyr 
    770                 775                 780                 


Thr Ala Val Lys Leu Asn Arg Glu Val Arg Asp Tyr Tyr Glu Leu Val 
785                 790                 795                 800 


Val Val Ala Thr Asp Gly Ala Val His Pro Arg His Ser Thr Leu Thr 
                805                 810                 815     


Leu Ala Ile Lys Val Leu Asp Ile Asp Asp Asn Ser Pro Val Phe Thr 
            820                 825                 830         


Asn Ser Thr Tyr Thr Val Leu Val Glu Glu Asn Leu Pro Ala Gly Thr 
        835                 840                 845             


Thr Ile Leu Gln Ile Glu Ala Lys Asp Val Asp Leu Gly Ala Asn Val 
    850                 855                 860                 


Ser Tyr Arg Ile Arg Ser Pro Glu Val Lys His Phe Phe Ala Leu His 
865                 870                 875                 880 


Pro Phe Thr Gly Glu Leu Ser Leu Leu Arg Ser Leu Asp Tyr Glu Ala 
                885                 890                 895     


Phe Pro Asp Gln Glu Ala Ser Ile Thr Phe Leu Val Glu Ala Phe Asp 
            900                 905                 910         


Ile Tyr Gly Thr Met Pro Pro Gly Ile Ala Thr Val Thr Val Ile Val 
        915                 920                 925             


Lys Asp Met Asn Asp Tyr Pro Pro Val Phe Ser Lys Arg Ile Tyr Lys 
    930                 935                 940                 


Gly Met Val Ala Pro Asp Ala Val Lys Gly Thr Pro Ile Thr Thr Val 
945                 950                 955                 960 


Tyr Ala Glu Asp Ala Asp Pro Pro Gly Leu Pro Ala Ser Arg Val Arg 
                965                 970                 975     


Tyr Arg Val Asp Asp Val Gln Phe Pro Tyr Pro Ala Ser Ile Phe Glu 
            980                 985                 990         


Val Glu Glu Asp Ser Gly Arg Val  Ile Thr Arg Val Asn  Leu Asn Glu 
        995                 1000                 1005             


Glu Pro  Thr Thr Ile Phe Lys  Leu Val Val Val Ala  Phe Asp Asp 
    1010                 1015                 1020             


Gly Glu  Pro Val Met Ser Ser  Ser Ala Thr Val Lys  Ile Leu Val 
    1025                 1030                 1035             


Leu His  Pro Gly Glu Ile Pro  Arg Phe Thr Gln Glu  Glu Tyr Arg 
    1040                 1045                 1050             


Pro Pro  Pro Val Ser Glu Leu  Ala Thr Lys Gly Thr  Met Val Gly 
    1055                 1060                 1065             


Val Ile  Ser Ala Ala Ala Ile  Asn Gln Ser Ile Val  Tyr Ser Ile 
    1070                 1075                 1080             


Val Ser  Gly Asn Glu Glu Asp  Thr Phe Gly Ile Asn  Asn Ile Thr 
    1085                 1090                 1095             


Gly Val  Ile Tyr Val Asn Gly  Pro Leu Asp Tyr Glu  Thr Arg Thr 
    1100                 1105                 1110             


Ser Tyr  Val Leu Arg Val Gln  Ala Asp Ser Leu Glu  Val Val Leu 
    1115                 1120                 1125             


Ala Asn  Leu Arg Val Pro Ser  Lys Ser Asn Thr Ala  Lys Val Tyr 
    1130                 1135                 1140             


Ile Glu  Ile Gln Asp Glu Asn  Asn His Pro Pro Val  Phe Gln Lys 
    1145                 1150                 1155             


Lys Phe  Tyr Ile Gly Gly Val  Ser Glu Asp Ala Arg  Met Phe Thr 
    1160                 1165                 1170             


Ser Val  Leu Arg Val Lys Ala  Thr Asp Lys Asp Thr  Gly Asn Tyr 
    1175                 1180                 1185             


Ser Val  Met Ala Tyr Arg Leu  Ile Ile Pro Pro Ile  Lys Glu Gly 
    1190                 1195                 1200             


Lys Glu  Gly Phe Val Val Glu  Thr Tyr Thr Gly Leu  Ile Lys Thr 
    1205                 1210                 1215             


Ala Met  Leu Phe His Asn Met  Arg Arg Ser Tyr Phe  Lys Phe Gln 
    1220                 1225                 1230             


Val Ile  Ala Thr Asp Asp Tyr  Gly Lys Gly Leu Ser  Gly Lys Ala 
    1235                 1240                 1245             


Asp Val  Leu Val Ser Val Val  Asn Gln Leu Asp Met  Gln Val Ile 
    1250                 1255                 1260             


Val Ser  Asn Val Pro Pro Thr  Leu Val Glu Lys Lys  Ile Glu Asp 
    1265                 1270                 1275             


Leu Thr  Glu Ile Leu Asp Arg  Tyr Val Gln Glu Gln  Ile Pro Gly 
    1280                 1285                 1290             


Ala Lys  Val Val Val Glu Ser  Ile Gly Ala Arg Arg  His Gly Asp 
    1295                 1300                 1305             


Ala Phe  Ser Leu Glu Asp Tyr  Thr Lys Cys Asp Leu  Thr Val Tyr 
    1310                 1315                 1320             


Ala Ile  Asp Pro Gln Thr Asn  Arg Ala Ile Asp Arg  Asn Glu Leu 
    1325                 1330                 1335             


Phe Lys  Phe Leu Asp Gly Lys  Leu Leu Asp Ile Asn  Lys Asp Phe 
    1340                 1345                 1350             


Gln Pro  Tyr Tyr Gly Glu Gly  Gly Arg Ile Leu Glu  Ile Arg Thr 
    1355                 1360                 1365             


Pro Glu  Ala Val Thr Ser Ile  Lys Lys Arg Gly Glu  Ser Leu Gly 
    1370                 1375                 1380             


Tyr Thr  Glu Gly Ala Leu Leu  Ala Leu Ala Phe Ile  Ile Ile Leu 
    1385                 1390                 1395             


Cys Cys  Ile Pro Ala Ile Leu  Val Val Leu Val Ser  Tyr Arg Gln 
    1400                 1405                 1410             


Phe Lys  Val Arg Gln Ala Glu  Cys Thr Lys Thr Ala  Arg Ile Gln 
    1415                 1420                 1425             


Ala Ala  Leu Pro Ala Ala Lys  Pro Ala Val Pro Ala  Pro Ala Pro 
    1430                 1435                 1440             


Val Ala  Ala Pro Pro Pro Pro  Pro Pro Pro Pro Pro  Gly Ala His 
    1445                 1450                 1455             


Leu Tyr  Glu Glu Leu Gly Asp  Ser Ser Met His Lys  Tyr Glu Met 
    1460                 1465                 1470             


Pro Gln  Tyr Gly Ser Arg Arg  Arg Leu Leu Pro Pro  Ala Gly Gln 
    1475                 1480                 1485             


Glu Glu  Tyr Gly Glu Val Val  Gly Glu Ala Glu Glu  Glu Tyr Glu 
    1490                 1495                 1500             


Glu Glu  Glu Glu Glu Pro Lys  Lys Ile Lys Lys Pro  Lys Val Glu 
    1505                 1510                 1515             


Ile Arg  Glu Pro Ser Glu Glu  Glu Glu Val Val Val  Thr Ile Glu 
    1520                 1525                 1530             


Lys Pro  Pro Ala Ala Glu Pro  Thr Tyr Thr Thr Trp  Lys Arg Ala 
    1535                 1540                 1545             


Arg Ile  Phe Pro Met Ile Phe  Lys Lys Val Arg Gly  Leu Ala Asp 
    1550                 1555                 1560             


Lys Arg  Gly Ile Val Asp Leu  Glu Gly Glu Glu Trp  Gln Arg Arg 
    1565                 1570                 1575             


Leu Glu  Glu Glu Asp Lys Asp  Tyr Leu Lys Leu Thr  Leu Asp Gln 
    1580                 1585                 1590             


Glu Glu  Ala Thr Glu Ser Thr  Val Glu Ser Glu Glu  Glu Ser Ser 
    1595                 1600                 1605             


Ser Asp  Tyr Thr Glu Tyr Ser  Glu Glu Glu Ser Glu  Phe Ser Glu 
    1610                 1615                 1620             


Ser Glu  Thr Thr Glu Glu Glu  Ser Glu Ser Glu Thr  Pro Ser Glu 
    1625                 1630                 1635             


Glu Glu  Glu Ser Ser Thr Pro  Glu Ser Glu Glu Ser  Glu Ser Thr 
    1640                 1645                 1650             


Glu Ser  Glu Gly Glu Lys Ala  Arg Lys Asn Ile Val  Leu Ala Arg 
    1655                 1660                 1665             


Arg Arg  Pro Met Val Glu Glu  Val Lys Glu Val Lys  Gly Arg Lys 
    1670                 1675                 1680             


Glu Glu  Pro Gln Glu Glu Gln  Lys Glu Pro Lys Met  Glu Glu Glu 
    1685                 1690                 1695             


Glu His  Ser Glu Glu Glu Glu  Ser Gly Pro Ala Pro  Val Glu Glu 
    1700                 1705                 1710             


Ser Thr  Asp Pro Glu Ala Gln  Asp Ile Pro Glu Glu  Gly Ser Ala 
    1715                 1720                 1725             


Glu Ser  Ala Ser Val Glu Gly  Gly Val Glu Ser Glu  Glu Glu Ser 
    1730                 1735                 1740             


Glu Ser  Gly Ser Ser Ser Ser  Ser Ser Glu Ser Gln  Ser Gly Gly 
    1745                 1750                 1755             


Pro Trp  Gly Tyr Gln Val Pro  Ala Tyr Asp Arg Ser  Lys Asn Ala 
    1760                 1765                 1770             


Asn Gln  Lys Lys Ser Pro Gly  Ala Asn Ser Glu Gly  Tyr Asn Thr 
    1775                 1780                 1785             


Ala Leu  
    1790 


<210>  1695
<211>  1539
<212>  PRT
<213>  Homo sapiens

<400>  1695

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Cys 
            20                  25                  30          


Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu 
        35                  40                  45              


Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly 
    50                  55                  60                  


Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn 
65                  70                  75                  80  


Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln Met Leu Phe Leu 
                85                  90                  95      


Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro Pro Met Asn Ile His 
            100                 105                 110         


Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys Lys Val Gly Thr Ile 
        115                 120                 125             


Ile Tyr His Glu Val Arg Ile Val Val Arg Asp Arg Asn Asp Asn Ser 
    130                 135                 140                 


Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr 
145                 150                 155                 160 


Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala 
                165                 170                 175     


Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln 
            180                 185                 190         


Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu 
        195                 200                 205             


Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp 
    210                 215                 220                 


Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn 
225                 230                 235                 240 


Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu Thr Val Asp Val Leu 
                245                 250                 255     


Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro Cys Val Leu Val Pro 
            260                 265                 270         


Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu 
        275                 280                 285             


Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile Val Thr Pro Pro Ile 
    290                 295                 300                 


Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro 
305                 310                 315                 320 


Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg 
                325                 330                 335     


Phe Phe His Met His Pro Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro 
            340                 345                 350         


Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu Val Ile Lys Ala Glu 
        355                 360                 365             


Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala Gly Leu His Ile Glu 
    370                 375                 380                 


Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr 
385                 390                 395                 400 


Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly Ala Thr Ile Ser Asp 
                405                 410                 415     


Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val Ala Leu Asp Lys Asp 
            420                 425                 430         


Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu Phe Leu Asn Asp Tyr 
        435                 440                 445             


Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr 
    450                 455                 460                 


Leu Leu Gln Pro Val Asp Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser 
465                 470                 475                 480 


Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu Pro Val Ile Val Asn 
                485                 490                 495     


Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile 
            500                 505                 510         


Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg Pro Gly Asp Ser Val 
        515                 520                 525             


Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile 
    530                 535                 540                 


Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys 
545                 550                 555                 560 


Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val Glu Met Ile Val Gly 
                565                 570                 575     


Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp Asn Ala Pro Pro Ala 
            580                 585                 590         


Glu Arg Arg Asn Ser Ile Cys Thr Val Tyr Ile Glu Val Leu Pro Pro 
        595                 600                 605             


Asn Asn Gln Ser Pro Pro Arg Phe Pro Gln Leu Met Tyr Ser Leu Glu 
    610                 615                 620                 


Ile Ser Glu Ala Met Arg Val Gly Ala Val Leu Leu Asn Leu Gln Ala 
625                 630                 635                 640 


Thr Asp Arg Glu Gly Asp Ser Ile Thr Tyr Ala Ile Glu Asn Gly Asp 
                645                 650                 655     


Pro Gln Arg Val Phe Asn Leu Ser Glu Thr Thr Gly Ile Leu Thr Leu 
            660                 665                 670         


Gly Lys Ala Leu Asp Arg Glu Ser Thr Asp Arg Tyr Ile Leu Ile Ile 
        675                 680                 685             


Thr Ala Ser Asp Gly Arg Pro Asp Gly Thr Ser Thr Ala Thr Val Asn 
    690                 695                 700                 


Ile Val Val Thr Asp Val Asn Asp Asn Ala Pro Val Phe Asp Pro Tyr 
705                 710                 715                 720 


Leu Pro Arg Asn Leu Ser Val Val Glu Glu Glu Ala Asn Ala Phe Val 
                725                 730                 735     


Gly Gln Val Lys Ala Thr Asp Pro Asp Ala Gly Ile Asn Gly Gln Val 
            740                 745                 750         


His Tyr Ser Leu Gly Asn Phe Asn Asn Leu Phe Arg Ile Thr Ser Asn 
        755                 760                 765             


Gly Ser Ile Tyr Thr Ala Val Lys Leu Asn Arg Glu Val Arg Asp Tyr 
    770                 775                 780                 


Tyr Glu Leu Val Val Val Ala Thr Asp Gly Ala Val His Pro Arg His 
785                 790                 795                 800 


Ser Thr Leu Thr Leu Ala Ile Lys Val Leu Asp Ile Asp Asp Asn Ser 
                805                 810                 815     


Pro Val Phe Thr Asn Ser Thr Tyr Thr Val Leu Val Glu Glu Asn Leu 
            820                 825                 830         


Pro Ala Gly Thr Thr Ile Leu Gln Ile Glu Ala Lys Asp Val Asp Leu 
        835                 840                 845             


Gly Ala Asn Val Ser Tyr Arg Ile Arg Ser Pro Glu Val Lys His Phe 
    850                 855                 860                 


Phe Ala Leu His Pro Phe Thr Gly Glu Leu Ser Leu Leu Arg Ser Leu 
865                 870                 875                 880 


Asp Tyr Glu Ala Phe Pro Asp Gln Glu Ala Ser Ile Thr Phe Leu Val 
                885                 890                 895     


Glu Ala Phe Asp Ile Tyr Gly Thr Met Pro Pro Gly Ile Ala Thr Val 
            900                 905                 910         


Thr Val Ile Val Lys Asp Met Asn Asp Tyr Pro Pro Val Phe Ser Lys 
        915                 920                 925             


Arg Ile Tyr Lys Gly Met Val Ala Pro Asp Ala Val Lys Gly Thr Pro 
    930                 935                 940                 


Ile Thr Thr Val Tyr Ala Glu Asp Ala Asp Pro Pro Gly Leu Pro Ala 
945                 950                 955                 960 


Ser Arg Val Arg Tyr Arg Val Asp Asp Val Gln Phe Pro Tyr Pro Ala 
                965                 970                 975     


Ser Ile Phe Glu Val Glu Glu Asp Ser Gly Arg Val Ile Thr Arg Val 
            980                 985                 990         


Asn Leu Asn Glu Glu Pro Thr Thr  Ile Phe Lys Leu Val  Val Val Ala 
        995                 1000                 1005             


Phe Asp  Asp Gly Glu Pro Val  Met Ser Ser Ser Ala  Thr Val Lys 
    1010                 1015                 1020             


Ile Leu  Val Leu His Pro Gly  Glu Ile Pro Arg Phe  Thr Gln Glu 
    1025                 1030                 1035             


Glu Tyr  Arg Pro Pro Pro Val  Ser Glu Leu Ala Thr  Lys Gly Thr 
    1040                 1045                 1050             


Met Val  Gly Val Ile Ser Ala  Ala Ala Ile Asn Gln  Ser Ile Val 
    1055                 1060                 1065             


Tyr Ser  Ile Val Ser Gly Asn  Glu Glu Asp Thr Phe  Gly Ile Asn 
    1070                 1075                 1080             


Asn Ile  Thr Gly Val Ile Tyr  Val Asn Gly Pro Leu  Asp Tyr Glu 
    1085                 1090                 1095             


Thr Arg  Thr Ser Tyr Val Leu  Arg Val Gln Ala Asp  Ser Leu Glu 
    1100                 1105                 1110             


Val Val  Leu Ala Asn Leu Arg  Val Pro Ser Lys Ser  Asn Thr Ala 
    1115                 1120                 1125             


Lys Val  Tyr Ile Glu Ile Gln  Asp Glu Asn Asn His  Pro Pro Val 
    1130                 1135                 1140             


Phe Gln  Lys Lys Phe Tyr Ile  Gly Gly Val Ser Glu  Asp Ala Arg 
    1145                 1150                 1155             


Met Phe  Thr Ser Val Leu Arg  Val Lys Ala Thr Asp  Lys Asp Thr 
    1160                 1165                 1170             


Gly Asn  Tyr Ser Val Met Ala  Tyr Arg Leu Ile Ile  Pro Pro Ile 
    1175                 1180                 1185             


Lys Glu  Gly Lys Glu Gly Phe  Val Val Glu Thr Tyr  Thr Gly Leu 
    1190                 1195                 1200             


Ile Lys  Thr Ala Met Leu Phe  His Asn Met Arg Arg  Ser Tyr Phe 
    1205                 1210                 1215             


Lys Phe  Gln Val Ile Ala Thr  Asp Asp Tyr Gly Lys  Gly Leu Ser 
    1220                 1225                 1230             


Gly Lys  Ala Asp Val Leu Val  Ser Val Val Asn Gln  Leu Asp Met 
    1235                 1240                 1245             


Gln Val  Ile Val Ser Asn Val  Pro Pro Thr Leu Val  Glu Lys Lys 
    1250                 1255                 1260             


Ile Glu  Asp Leu Thr Glu Ile  Leu Asp Arg Tyr Val  Gln Glu Gln 
    1265                 1270                 1275             


Ile Pro  Gly Ala Lys Val Val  Val Glu Ser Ile Gly  Ala Arg Arg 
    1280                 1285                 1290             


His Gly  Asp Ala Phe Ser Leu  Glu Asp Tyr Thr Lys  Cys Asp Leu 
    1295                 1300                 1305             


Thr Val  Tyr Ala Ile Asp Pro  Gln Thr Asn Arg Ala  Ile Asp Arg 
    1310                 1315                 1320             


Asn Glu  Leu Phe Lys Phe Leu  Asp Gly Lys Leu Leu  Asp Ile Asn 
    1325                 1330                 1335             


Lys Asp  Phe Gln Pro Tyr Tyr  Gly Glu Gly Gly Arg  Ile Leu Glu 
    1340                 1345                 1350             


Ile Arg  Thr Pro Glu Ala Val  Thr Ser Ile Lys Lys  Arg Gly Glu 
    1355                 1360                 1365             


Ser Leu  Gly Tyr Thr Glu Gly  Ala Leu Leu Ala Leu  Ala Phe Ile 
    1370                 1375                 1380             


Ile Ile  Leu Cys Cys Ile Pro  Ala Ile Leu Val Val  Leu Val Ser 
    1385                 1390                 1395             


Tyr Arg  Gln Phe Lys Val Arg  Gln Ala Glu Cys Thr  Lys Thr Ala 
    1400                 1405                 1410             


Arg Ile  Gln Ala Ala Leu Pro  Ala Ala Lys Pro Ala  Val Pro Ala 
    1415                 1420                 1425             


Pro Ala  Pro Val Ala Ala Pro  Pro Pro Pro Pro Pro  Pro Pro Pro 
    1430                 1435                 1440             


Gly Ala  His Leu Tyr Glu Glu  Leu Gly Asp Ser Ser  Met His Lys 
    1445                 1450                 1455             


Asn Tyr  Pro Trp Ser Leu Glu  Leu Ile Leu Ala Arg  Asn Met Asp 
    1460                 1465                 1470             


Lys Ile  Ile Thr Val Met Ser  Met Gly Met Lys Cys  Leu Asn Met 
    1475                 1480                 1485             


Gly Val  Ala Val Asp Cys Tyr  His Gln Leu Asp Arg  Arg Asn Met 
    1490                 1495                 1500             


Val Arg  Trp Leu Val Lys Leu  Arg Lys Asn Met Arg  Arg Lys Arg 
    1505                 1510                 1515             


Lys Ser  Gln Arg Lys Leu Lys  Asn Gln Arg Leu Lys  Leu Glu Ser 
    1520                 1525                 1530             


Leu Val  Arg Arg Lys Lys 
    1535                 


<210>  1696
<211>  1682
<212>  PRT
<213>  Homo sapiens

<400>  1696

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Trp 
            20                  25                  30          


Gln Tyr Glu Asp Cys Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile 
        35                  40                  45              


Val Ala Ile Asp Glu Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn 
    50                  55                  60                  


Met Leu Ile Lys Gly Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu 
65                  70                  75                  80  


Ser Leu Lys Asp Asn Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys 
                85                  90                  95      


Gln Met Leu Phe Leu Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro 
            100                 105                 110         


Pro Met Asn Ile His Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys 
        115                 120                 125             


Lys Val Gly Thr Ile Ile Tyr His Glu Val Arg Ile Val Val Arg Asp 
    130                 135                 140                 


Arg Asn Asp Asn Ser Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr 
145                 150                 155                 160 


Val Asn Glu Leu Thr Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser 
                165                 170                 175     


Gly Asp Asn Gly Ala Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile 
            180                 185                 190         


Glu Tyr Val Ile Gln Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr 
        195                 200                 205             


Phe Glu Ile Pro Leu Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg 
    210                 215                 220                 


Leu Asn Tyr Glu Asp Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn 
225                 230                 235                 240 


Asp Arg Ala Gln Asn Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu 
                245                 250                 255     


Thr Val Asp Val Leu Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro 
            260                 265                 270         


Cys Val Leu Val Pro Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln 
        275                 280                 285             


Ala Ala Ile Pro Glu Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile 
    290                 295                 300                 


Val Thr Pro Pro Ile Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro 
305                 310                 315                 320 


Pro Ser Asp Arg Pro Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro 
                325                 330                 335     


Glu Asp Tyr Pro Arg Phe Phe His Met His Pro Arg Thr Ala Glu Leu 
            340                 345                 350         


Ser Leu Leu Glu Pro Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu 
        355                 360                 365             


Val Ile Lys Ala Glu Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala 
    370                 375                 380                 


Gly Leu His Ile Glu Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe 
385                 390                 395                 400 


Thr Met Pro Ser Tyr Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly 
                405                 410                 415     


Ala Thr Ile Ser Asp Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val 
            420                 425                 430         


Ala Leu Asp Lys Asp Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu 
        435                 440                 445             


Phe Leu Asn Asp Tyr Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile 
    450                 455                 460                 


Thr Arg Tyr Leu Thr Leu Leu Gln Pro Val Asp Arg Glu Glu Gln Gln 
465                 470                 475                 480 


Thr Tyr Thr Phe Ser Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu 
                485                 490                 495     


Pro Val Ile Val Asn Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro 
            500                 505                 510         


Thr Phe Pro Glu Ile Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg 
        515                 520                 525             


Pro Gly Asp Ser Val Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly 
    530                 535                 540                 


Ser Asn Gly Glu Ile Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp 
545                 550                 555                 560 


Phe Ile Ile Asn Lys Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val 
                565                 570                 575     


Glu Met Ile Val Gly Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp 
            580                 585                 590         


Asn Ala Pro Pro Ala Glu Arg Arg Asn Ser Ile Cys Thr Val Tyr Ile 
        595                 600                 605             


Glu Val Leu Pro Pro Asn Asn Gln Ser Pro Pro Arg Phe Pro Gln Leu 
    610                 615                 620                 


Met Tyr Ser Leu Glu Ile Ser Glu Ala Met Arg Val Gly Ala Val Leu 
625                 630                 635                 640 


Leu Asn Leu Gln Ala Thr Asp Arg Glu Gly Asp Ser Ile Thr Tyr Ala 
                645                 650                 655     


Ile Glu Asn Gly Asp Pro Gln Arg Val Phe Asn Leu Ser Glu Thr Thr 
            660                 665                 670         


Gly Ile Leu Thr Leu Gly Lys Ala Leu Asp Arg Glu Ser Thr Asp Arg 
        675                 680                 685             


Tyr Ile Leu Ile Ile Thr Ala Ser Asp Gly Arg Pro Asp Gly Thr Ser 
    690                 695                 700                 


Thr Ala Thr Val Asn Ile Val Val Thr Asp Val Asn Asp Asn Ala Pro 
705                 710                 715                 720 


Val Phe Asp Pro Tyr Leu Pro Arg Asn Leu Ser Val Val Glu Glu Glu 
                725                 730                 735     


Ala Asn Ala Phe Val Gly Gln Val Lys Ala Thr Asp Pro Asp Ala Gly 
            740                 745                 750         


Ile Asn Gly Gln Val His Tyr Ser Leu Gly Asn Phe Asn Asn Leu Phe 
        755                 760                 765             


Arg Ile Thr Ser Asn Gly Ser Ile Tyr Thr Ala Val Lys Leu Asn Arg 
    770                 775                 780                 


Glu Val Arg Asp Tyr Tyr Glu Leu Val Val Val Ala Thr Asp Gly Ala 
785                 790                 795                 800 


Val His Pro Arg His Ser Thr Leu Thr Leu Ala Ile Lys Val Leu Asp 
                805                 810                 815     


Ile Asp Asp Asn Ser Pro Val Phe Thr Asn Ser Thr Tyr Thr Val Leu 
            820                 825                 830         


Val Glu Glu Asn Leu Pro Ala Gly Thr Thr Ile Leu Gln Ile Glu Ala 
        835                 840                 845             


Lys Asp Val Asp Leu Gly Ala Asn Val Ser Tyr Arg Ile Arg Ser Pro 
    850                 855                 860                 


Glu Val Lys His Phe Phe Ala Leu His Pro Phe Thr Gly Glu Leu Ser 
865                 870                 875                 880 


Leu Leu Arg Ser Leu Asp Tyr Glu Ala Phe Pro Asp Gln Glu Ala Ser 
                885                 890                 895     


Ile Thr Phe Leu Val Glu Ala Phe Asp Ile Tyr Gly Thr Met Pro Pro 
            900                 905                 910         


Gly Ile Ala Thr Val Thr Val Ile Val Lys Asp Met Asn Asp Tyr Pro 
        915                 920                 925             


Pro Val Phe Ser Lys Arg Ile Tyr Lys Gly Met Val Ala Pro Asp Ala 
    930                 935                 940                 


Val Lys Gly Thr Pro Ile Thr Thr Val Tyr Ala Glu Asp Ala Asp Pro 
945                 950                 955                 960 


Pro Gly Leu Pro Ala Ser Arg Val Arg Tyr Arg Val Asp Asp Val Gln 
                965                 970                 975     


Phe Pro Tyr Pro Ala Ser Ile Phe Glu Val Glu Glu Asp Ser Gly Arg 
            980                 985                 990         


Val Ile Thr Arg Val Asn Leu Asn  Glu Glu Pro Thr Thr  Ile Phe Lys 
        995                 1000                 1005             


Leu Val  Val Val Ala Phe Asp  Asp Gly Glu Pro Val  Met Ser Ser 
    1010                 1015                 1020             


Ser Ala  Thr Val Lys Ile Leu  Val Leu His Pro Gly  Glu Ile Pro 
    1025                 1030                 1035             


Arg Phe  Thr Gln Glu Glu Tyr  Arg Pro Pro Pro Val  Ser Glu Leu 
    1040                 1045                 1050             


Ala Thr  Lys Gly Thr Met Val  Gly Val Ile Ser Ala  Ala Ala Ile 
    1055                 1060                 1065             


Asn Gln  Ser Ile Val Tyr Ser  Ile Val Ser Gly Asn  Glu Glu Asp 
    1070                 1075                 1080             


Thr Phe  Gly Ile Asn Asn Ile  Thr Gly Val Ile Tyr  Val Asn Gly 
    1085                 1090                 1095             


Pro Leu  Asp Tyr Glu Thr Arg  Thr Ser Tyr Val Leu  Arg Val Gln 
    1100                 1105                 1110             


Ala Asp  Ser Leu Glu Val Val  Leu Ala Asn Leu Arg  Val Pro Ser 
    1115                 1120                 1125             


Lys Ser  Asn Thr Ala Lys Val  Tyr Ile Glu Ile Gln  Asp Glu Asn 
    1130                 1135                 1140             


Asn His  Pro Pro Val Phe Gln  Lys Lys Phe Tyr Ile  Gly Gly Val 
    1145                 1150                 1155             


Ser Glu  Asp Ala Arg Met Phe  Thr Ser Val Leu Arg  Val Lys Ala 
    1160                 1165                 1170             


Thr Asp  Lys Asp Thr Gly Asn  Tyr Ser Val Met Ala  Tyr Arg Leu 
    1175                 1180                 1185             


Ile Ile  Pro Pro Ile Lys Glu  Gly Lys Glu Gly Phe  Val Val Glu 
    1190                 1195                 1200             


Thr Tyr  Thr Gly Leu Ile Lys  Thr Ala Met Leu Phe  His Asn Met 
    1205                 1210                 1215             


Arg Arg  Ser Tyr Phe Lys Phe  Gln Val Ile Ala Thr  Asp Asp Tyr 
    1220                 1225                 1230             


Gly Lys  Gly Leu Ser Gly Lys  Ala Asp Val Leu Val  Ser Val Val 
    1235                 1240                 1245             


Asn Gln  Leu Asp Met Gln Val  Ile Val Ser Asn Val  Pro Pro Thr 
    1250                 1255                 1260             


Leu Val  Glu Lys Lys Ile Glu  Asp Leu Thr Glu Ile  Leu Asp Arg 
    1265                 1270                 1275             


Tyr Val  Gln Glu Gln Ile Pro  Gly Ala Lys Val Val  Val Glu Ser 
    1280                 1285                 1290             


Ile Gly  Ala Arg Arg His Gly  Asp Ala Phe Ser Leu  Glu Asp Tyr 
    1295                 1300                 1305             


Thr Lys  Cys Asp Leu Thr Val  Tyr Ala Ile Asp Pro  Gln Thr Asn 
    1310                 1315                 1320             


Arg Ala  Ile Asp Arg Asn Glu  Leu Phe Lys Phe Leu  Asp Gly Lys 
    1325                 1330                 1335             


Leu Leu  Asp Ile Asn Lys Asp  Phe Gln Pro Tyr Tyr  Gly Glu Gly 
    1340                 1345                 1350             


Gly Arg  Ile Leu Glu Ile Arg  Thr Pro Glu Ala Val  Thr Ser Ile 
    1355                 1360                 1365             


Lys Lys  Arg Gly Glu Ser Leu  Gly Tyr Thr Glu Gly  Ala Leu Leu 
    1370                 1375                 1380             


Ala Leu  Ala Phe Ile Ile Ile  Leu Cys Cys Ile Pro  Ala Ile Leu 
    1385                 1390                 1395             


Val Val  Leu Val Ser Tyr Arg  Gln Phe Lys Val Arg  Gln Ala Glu 
    1400                 1405                 1410             


Cys Thr  Lys Thr Ala Arg Ile  Gln Ala Ala Leu Pro  Ala Ala Lys 
    1415                 1420                 1425             


Pro Ala  Val Pro Ala Pro Ala  Pro Val Ala Ala Pro  Pro Pro Pro 
    1430                 1435                 1440             


Pro Pro  Pro Pro Pro Gly Ala  His Leu Tyr Glu Glu  Leu Gly Asp 
    1445                 1450                 1455             


Ser Ser  Met His Lys Tyr Glu  Met Pro Gln Tyr Gly  Ser Arg Arg 
    1460                 1465                 1470             


Arg Leu  Leu Pro Pro Ala Gly  Gln Glu Glu Tyr Gly  Glu Val Val 
    1475                 1480                 1485             


Gly Glu  Ala Glu Glu Glu Tyr  Glu Glu Glu Glu Trp  Ala Arg Lys 
    1490                 1495                 1500             


Arg Met  Ile Lys Leu Val Val  Asp Arg Glu Tyr Glu  Thr Ser Ser 
    1505                 1510                 1515             


Thr Gly  Glu Asp Ser Ala Pro  Glu Cys Gln Arg Asn  Arg Leu His 
    1520                 1525                 1530             


His Pro  Ser Ile His Ser Asn  Ile Asn Gly Asn Ile  Tyr Ile Ala 
    1535                 1540                 1545             


Gln Asn  Gly Ser Val Val Arg  Thr Arg Arg Ala Cys  Leu Thr Asp 
    1550                 1555                 1560             


Asn Leu  Lys Val Ala Ser Pro  Val Arg Leu Gly Gly  Pro Phe Lys 
    1565                 1570                 1575             


Lys Leu  Asp Lys Leu Ala Val  Thr His Glu Glu Asn  Val Pro Leu 
    1580                 1585                 1590             


Asn Thr  Leu Ser Lys Gly Pro  Phe Ser Thr Glu Lys  Met Asn Ala 
    1595                 1600                 1605             


Arg Pro  Thr Leu Val Thr Phe  Ala Pro Cys Pro Val  Gly Thr Asp 
    1610                 1615                 1620             


Asn Thr  Ala Val Lys Pro Leu  Arg Asn Arg Leu Lys  Ser Thr Val 
    1625                 1630                 1635             


Glu Gln  Glu Ser Met Ile Asp  Ser Lys Asn Ile Lys  Glu Ala Leu 
    1640                 1645                 1650             


Glu Phe  His Ser Asp His Thr  Gln Ser Asp Asp Glu  Glu Leu Trp 
    1655                 1660                 1665             


Met Gly  Pro Trp Asn Asn Leu  His Ile Pro Met Thr  Lys Leu 
    1670                 1675                 1680         


<210>  1697
<211>  1677
<212>  PRT
<213>  Homo sapiens

<400>  1697

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Cys 
            20                  25                  30          


Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu 
        35                  40                  45              


Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly 
    50                  55                  60                  


Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn 
65                  70                  75                  80  


Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln Met Leu Phe Leu 
                85                  90                  95      


Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro Pro Met Asn Ile His 
            100                 105                 110         


Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys Lys Val Gly Thr Ile 
        115                 120                 125             


Ile Tyr His Glu Val Arg Ile Val Val Arg Asp Arg Asn Asp Asn Ser 
    130                 135                 140                 


Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr 
145                 150                 155                 160 


Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala 
                165                 170                 175     


Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln 
            180                 185                 190         


Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu 
        195                 200                 205             


Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp 
    210                 215                 220                 


Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn 
225                 230                 235                 240 


Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu Thr Val Asp Val Leu 
                245                 250                 255     


Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro Cys Val Leu Val Pro 
            260                 265                 270         


Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu 
        275                 280                 285             


Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile Val Thr Pro Pro Ile 
    290                 295                 300                 


Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro 
305                 310                 315                 320 


Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg 
                325                 330                 335     


Phe Phe His Met His Pro Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro 
            340                 345                 350         


Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu Val Ile Lys Ala Glu 
        355                 360                 365             


Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala Gly Leu His Ile Glu 
    370                 375                 380                 


Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr 
385                 390                 395                 400 


Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly Ala Thr Ile Ser Asp 
                405                 410                 415     


Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val Ala Leu Asp Lys Asp 
            420                 425                 430         


Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu Phe Leu Asn Asp Tyr 
        435                 440                 445             


Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr 
    450                 455                 460                 


Leu Leu Gln Pro Val Asp Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser 
465                 470                 475                 480 


Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu Pro Val Ile Val Asn 
                485                 490                 495     


Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile 
            500                 505                 510         


Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg Pro Gly Asp Ser Val 
        515                 520                 525             


Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile 
    530                 535                 540                 


Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys 
545                 550                 555                 560 


Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val Glu Met Ile Val Gly 
                565                 570                 575     


Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp Asn Ala Pro Pro Ala 
            580                 585                 590         


Glu Arg Arg Asn Ser Ile Cys Thr Val Tyr Ile Glu Val Leu Pro Pro 
        595                 600                 605             


Asn Asn Gln Ser Pro Pro Arg Phe Pro Gln Leu Met Tyr Ser Leu Glu 
    610                 615                 620                 


Ile Ser Glu Ala Met Arg Val Gly Ala Val Leu Leu Asn Leu Gln Ala 
625                 630                 635                 640 


Thr Asp Arg Glu Gly Asp Ser Ile Thr Tyr Ala Ile Glu Asn Gly Asp 
                645                 650                 655     


Pro Gln Arg Val Phe Asn Leu Ser Glu Thr Thr Gly Ile Leu Thr Leu 
            660                 665                 670         


Gly Lys Ala Leu Asp Arg Glu Ser Thr Asp Arg Tyr Ile Leu Ile Ile 
        675                 680                 685             


Thr Ala Ser Asp Gly Arg Pro Asp Gly Thr Ser Thr Ala Thr Val Asn 
    690                 695                 700                 


Ile Val Val Thr Asp Val Asn Asp Asn Ala Pro Val Phe Asp Pro Tyr 
705                 710                 715                 720 


Leu Pro Arg Asn Leu Ser Val Val Glu Glu Glu Ala Asn Ala Phe Val 
                725                 730                 735     


Gly Gln Val Lys Ala Thr Asp Pro Asp Ala Gly Ile Asn Gly Gln Val 
            740                 745                 750         


His Tyr Ser Leu Gly Asn Phe Asn Asn Leu Phe Arg Ile Thr Ser Asn 
        755                 760                 765             


Gly Ser Ile Tyr Thr Ala Val Lys Leu Asn Arg Glu Val Arg Asp Tyr 
    770                 775                 780                 


Tyr Glu Leu Val Val Val Ala Thr Asp Gly Ala Val His Pro Arg His 
785                 790                 795                 800 


Ser Thr Leu Thr Leu Ala Ile Lys Val Leu Asp Ile Asp Asp Asn Ser 
                805                 810                 815     


Pro Val Phe Thr Asn Ser Thr Tyr Thr Val Leu Val Glu Glu Asn Leu 
            820                 825                 830         


Pro Ala Gly Thr Thr Ile Leu Gln Ile Glu Ala Lys Asp Val Asp Leu 
        835                 840                 845             


Gly Ala Asn Val Ser Tyr Arg Ile Arg Ser Pro Glu Val Lys His Phe 
    850                 855                 860                 


Phe Ala Leu His Pro Phe Thr Gly Glu Leu Ser Leu Leu Arg Ser Leu 
865                 870                 875                 880 


Asp Tyr Glu Ala Phe Pro Asp Gln Glu Ala Ser Ile Thr Phe Leu Val 
                885                 890                 895     


Glu Ala Phe Asp Ile Tyr Gly Thr Met Pro Pro Gly Ile Ala Thr Val 
            900                 905                 910         


Thr Val Ile Val Lys Asp Met Asn Asp Tyr Pro Pro Val Phe Ser Lys 
        915                 920                 925             


Arg Ile Tyr Lys Gly Met Val Ala Pro Asp Ala Val Lys Gly Thr Pro 
    930                 935                 940                 


Ile Thr Thr Val Tyr Ala Glu Asp Ala Asp Pro Pro Gly Leu Pro Ala 
945                 950                 955                 960 


Ser Arg Val Arg Tyr Arg Val Asp Asp Val Gln Phe Pro Tyr Pro Ala 
                965                 970                 975     


Ser Ile Phe Glu Val Glu Glu Asp Ser Gly Arg Val Ile Thr Arg Val 
            980                 985                 990         


Asn Leu Asn Glu Glu Pro Thr Thr  Ile Phe Lys Leu Val  Val Val Ala 
        995                 1000                 1005             


Phe Asp  Asp Gly Glu Pro Val  Met Ser Ser Ser Ala  Thr Val Lys 
    1010                 1015                 1020             


Ile Leu  Val Leu His Pro Gly  Glu Ile Pro Arg Phe  Thr Gln Glu 
    1025                 1030                 1035             


Glu Tyr  Arg Pro Pro Pro Val  Ser Glu Leu Ala Thr  Lys Gly Thr 
    1040                 1045                 1050             


Met Val  Gly Val Ile Ser Ala  Ala Ala Ile Asn Gln  Ser Ile Val 
    1055                 1060                 1065             


Tyr Ser  Ile Val Ser Gly Asn  Glu Glu Asp Thr Phe  Gly Ile Asn 
    1070                 1075                 1080             


Asn Ile  Thr Gly Val Ile Tyr  Val Asn Gly Pro Leu  Asp Tyr Glu 
    1085                 1090                 1095             


Thr Arg  Thr Ser Tyr Val Leu  Arg Val Gln Ala Asp  Ser Leu Glu 
    1100                 1105                 1110             


Val Val  Leu Ala Asn Leu Arg  Val Pro Ser Lys Ser  Asn Thr Ala 
    1115                 1120                 1125             


Lys Val  Tyr Ile Glu Ile Gln  Asp Glu Asn Asn His  Pro Pro Val 
    1130                 1135                 1140             


Phe Gln  Lys Lys Phe Tyr Ile  Gly Gly Val Ser Glu  Asp Ala Arg 
    1145                 1150                 1155             


Met Phe  Thr Ser Val Leu Arg  Val Lys Ala Thr Asp  Lys Asp Thr 
    1160                 1165                 1170             


Gly Asn  Tyr Ser Val Met Ala  Tyr Arg Leu Ile Ile  Pro Pro Ile 
    1175                 1180                 1185             


Lys Glu  Gly Lys Glu Gly Phe  Val Val Glu Thr Tyr  Thr Gly Leu 
    1190                 1195                 1200             


Ile Lys  Thr Ala Met Leu Phe  His Asn Met Arg Arg  Ser Tyr Phe 
    1205                 1210                 1215             


Lys Phe  Gln Val Ile Ala Thr  Asp Asp Tyr Gly Lys  Gly Leu Ser 
    1220                 1225                 1230             


Gly Lys  Ala Asp Val Leu Val  Ser Val Val Asn Gln  Leu Asp Met 
    1235                 1240                 1245             


Gln Val  Ile Val Ser Asn Val  Pro Pro Thr Leu Val  Glu Lys Lys 
    1250                 1255                 1260             


Ile Glu  Asp Leu Thr Glu Ile  Leu Asp Arg Tyr Val  Gln Glu Gln 
    1265                 1270                 1275             


Ile Pro  Gly Ala Lys Val Val  Val Glu Ser Ile Gly  Ala Arg Arg 
    1280                 1285                 1290             


His Gly  Asp Ala Phe Ser Leu  Glu Asp Tyr Thr Lys  Cys Asp Leu 
    1295                 1300                 1305             


Thr Val  Tyr Ala Ile Asp Pro  Gln Thr Asn Arg Ala  Ile Asp Arg 
    1310                 1315                 1320             


Asn Glu  Leu Phe Lys Phe Leu  Asp Gly Lys Leu Leu  Asp Ile Asn 
    1325                 1330                 1335             


Lys Asp  Phe Gln Pro Tyr Tyr  Gly Glu Gly Gly Arg  Ile Leu Glu 
    1340                 1345                 1350             


Ile Arg  Thr Pro Glu Ala Val  Thr Ser Ile Lys Lys  Arg Gly Glu 
    1355                 1360                 1365             


Ser Leu  Gly Tyr Thr Glu Gly  Ala Leu Leu Ala Leu  Ala Phe Ile 
    1370                 1375                 1380             


Ile Ile  Leu Cys Cys Ile Pro  Ala Ile Leu Val Val  Leu Val Ser 
    1385                 1390                 1395             


Tyr Arg  Gln Phe Lys Val Arg  Gln Ala Glu Cys Thr  Lys Thr Ala 
    1400                 1405                 1410             


Arg Ile  Gln Ala Ala Leu Pro  Ala Ala Lys Pro Ala  Val Pro Ala 
    1415                 1420                 1425             


Pro Ala  Pro Val Ala Ala Pro  Pro Pro Pro Pro Pro  Pro Pro Pro 
    1430                 1435                 1440             


Gly Ala  His Leu Tyr Glu Glu  Leu Gly Asp Ser Ser  Met His Lys 
    1445                 1450                 1455             


Tyr Glu  Met Pro Gln Tyr Gly  Ser Arg Arg Arg Leu  Leu Pro Pro 
    1460                 1465                 1470             


Ala Gly  Gln Glu Glu Tyr Gly  Glu Val Val Gly Glu  Ala Glu Glu 
    1475                 1480                 1485             


Glu Tyr  Glu Glu Glu Glu Trp  Ala Arg Lys Arg Met  Ile Lys Leu 
    1490                 1495                 1500             


Val Val  Asp Arg Glu Tyr Glu  Thr Ser Ser Thr Gly  Glu Asp Ser 
    1505                 1510                 1515             


Ala Pro  Glu Cys Gln Arg Asn  Arg Leu His His Pro  Ser Ile His 
    1520                 1525                 1530             


Ser Asn  Ile Asn Gly Asn Ile  Tyr Ile Ala Gln Asn  Gly Ser Val 
    1535                 1540                 1545             


Val Arg  Thr Arg Arg Ala Cys  Leu Thr Asp Asn Leu  Lys Val Ala 
    1550                 1555                 1560             


Ser Pro  Val Arg Leu Gly Gly  Pro Phe Lys Lys Leu  Asp Lys Leu 
    1565                 1570                 1575             


Ala Val  Thr His Glu Glu Asn  Val Pro Leu Asn Thr  Leu Ser Lys 
    1580                 1585                 1590             


Gly Pro  Phe Ser Thr Glu Lys  Met Asn Ala Arg Pro  Thr Leu Val 
    1595                 1600                 1605             


Thr Phe  Ala Pro Cys Pro Val  Gly Thr Asp Asn Thr  Ala Val Lys 
    1610                 1615                 1620             


Pro Leu  Arg Asn Arg Leu Lys  Ser Thr Val Glu Gln  Glu Ser Met 
    1625                 1630                 1635             


Ile Asp  Ser Lys Asn Ile Lys  Glu Ala Leu Glu Phe  His Ser Asp 
    1640                 1645                 1650             


His Thr  Gln Ser Asp Asp Glu  Glu Leu Trp Met Gly  Pro Trp Asn 
    1655                 1660                 1665             


Asn Leu  His Ile Pro Met Thr  Lys Leu 
    1670                 1675         


<210>  1698
<211>  1932
<212>  PRT
<213>  Homo sapiens

<400>  1698

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Gly Thr 
            20                  25                  30          


Ile Leu Val Asp Asn Met Leu Ile Lys Gly Thr Ala Gly Gly Pro Asp 
        35                  40                  45              


Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn Val Asp Tyr Trp Val Leu 
    50                  55                  60                  


Met Asp Pro Val Lys Gln Met Leu Phe Leu Asn Ser Thr Gly Arg Val 
65                  70                  75                  80  


Leu Asp Arg Asp Pro Pro Met Asn Ile His Ser Ile Val Val Gln Val 
                85                  90                  95      


Gln Cys Ile Asn Lys Lys Val Gly Thr Ile Ile Tyr His Glu Val Arg 
            100                 105                 110         


Ile Val Val Arg Asp Arg Asn Asp Asn Ser Pro Thr Phe Lys His Glu 
        115                 120                 125             


Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr Pro Val Gly Thr Thr Ile 
    130                 135                 140                 


Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala Thr Asp Ile Asp Asp Gly 
145                 150                 155                 160 


Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln Tyr Asn Pro Asp Asp Pro 
                165                 170                 175     


Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu Met Leu Thr Gly Asn Ile 
            180                 185                 190         


Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp Lys Thr Arg Tyr Phe Val 
        195                 200                 205             


Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn Leu Asn Glu Arg Arg Thr 
    210                 215                 220                 


Thr Thr Thr Thr Leu Thr Val Asp Val Leu Asp Gly Asp Asp Leu Gly 
225                 230                 235                 240 


Pro Met Phe Leu Pro Cys Val Leu Val Pro Asn Thr Arg Asp Cys Arg 
                245                 250                 255     


Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu Leu Arg Thr Pro Glu Glu 
            260                 265                 270         


Leu Asn Pro Ile Ile Val Thr Pro Pro Ile Gln Ala Ile Asp Gln Asp 
        275                 280                 285             


Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro Gly Ile Leu Tyr Ser Ile 
    290                 295                 300                 


Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg Phe Phe His Met His Pro 
305                 310                 315                 320 


Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro Val Asn Arg Asp Phe His 
                325                 330                 335     


Gln Lys Phe Asp Leu Val Ile Lys Ala Glu Gln Asp Asn Gly His Pro 
            340                 345                 350         


Leu Pro Ala Phe Ala Gly Leu His Ile Glu Ile Leu Asp Glu Asn Asn 
        355                 360                 365             


Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr Gln Gly Tyr Ile Leu Glu 
    370                 375                 380                 


Ser Ala Pro Val Gly Ala Thr Ile Ser Asp Ser Leu Asn Leu Thr Ser 
385                 390                 395                 400 


Pro Leu Arg Ile Val Ala Leu Asp Lys Asp Ile Glu Asp Thr Lys Asp 
                405                 410                 415     


Pro Glu Leu His Leu Phe Leu Asn Asp Tyr Thr Ser Val Phe Thr Val 
            420                 425                 430         


Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr Leu Leu Gln Pro Val Asp 
        435                 440                 445             


Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser Ile Thr Ala Phe Asp Gly 
    450                 455                 460                 


Val Gln Glu Ser Glu Pro Val Ile Val Asn Ile Gln Val Met Asp Ala 
465                 470                 475                 480 


Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile Ser Tyr Asp Val Tyr Val 
                485                 490                 495     


Tyr Thr Asp Met Arg Pro Gly Asp Ser Val Ile Gln Leu Thr Ala Val 
            500                 505                 510         


Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile Thr Tyr Glu Ile Leu Val 
        515                 520                 525             


Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys Thr Thr Gly Leu Ile Thr 
    530                 535                 540                 


Ile Ala Pro Gly Val Glu Met Ile Val Gly Arg Thr Tyr Ala Leu Thr 
545                 550                 555                 560 


Val Gln Ala Ala Asp Asn Ala Pro Pro Ala Glu Arg Arg Asn Ser Ile 
                565                 570                 575     


Cys Thr Val Tyr Ile Glu Val Leu Pro Pro Asn Asn Gln Ser Pro Pro 
            580                 585                 590         


Arg Phe Pro Gln Leu Met Tyr Ser Leu Glu Ile Ser Glu Ala Met Arg 
        595                 600                 605             


Val Gly Ala Val Leu Leu Asn Leu Gln Ala Thr Asp Arg Glu Gly Asp 
    610                 615                 620                 


Ser Ile Thr Tyr Ala Ile Glu Asn Gly Asp Pro Gln Arg Val Phe Asn 
625                 630                 635                 640 


Leu Ser Glu Thr Thr Gly Ile Leu Thr Leu Gly Lys Ala Leu Asp Arg 
                645                 650                 655     


Glu Ser Thr Asp Arg Tyr Ile Leu Ile Ile Thr Ala Ser Asp Gly Arg 
            660                 665                 670         


Pro Asp Gly Thr Ser Thr Ala Thr Val Asn Ile Val Val Thr Asp Val 
        675                 680                 685             


Asn Asp Asn Ala Pro Val Phe Asp Pro Tyr Leu Pro Arg Asn Leu Ser 
    690                 695                 700                 


Val Val Glu Glu Glu Ala Asn Ala Phe Val Gly Gln Val Lys Ala Thr 
705                 710                 715                 720 


Asp Pro Asp Ala Gly Ile Asn Gly Gln Val His Tyr Ser Leu Gly Asn 
                725                 730                 735     


Phe Asn Asn Leu Phe Arg Ile Thr Ser Asn Gly Ser Ile Tyr Thr Ala 
            740                 745                 750         


Val Lys Leu Asn Arg Glu Val Arg Asp Tyr Tyr Glu Leu Val Val Val 
        755                 760                 765             


Ala Thr Asp Gly Ala Val His Pro Arg His Ser Thr Leu Thr Leu Ala 
    770                 775                 780                 


Ile Lys Val Leu Asp Ile Asp Asp Asn Ser Pro Val Phe Thr Asn Ser 
785                 790                 795                 800 


Thr Tyr Thr Val Leu Val Glu Glu Asn Leu Pro Ala Gly Thr Thr Ile 
                805                 810                 815     


Leu Gln Ile Glu Ala Lys Asp Val Asp Leu Gly Ala Asn Val Ser Tyr 
            820                 825                 830         


Arg Ile Arg Ser Pro Glu Val Lys His Phe Phe Ala Leu His Pro Phe 
        835                 840                 845             


Thr Gly Glu Leu Ser Leu Leu Arg Ser Leu Asp Tyr Glu Ala Phe Pro 
    850                 855                 860                 


Asp Gln Glu Ala Ser Ile Thr Phe Leu Val Glu Ala Phe Asp Ile Tyr 
865                 870                 875                 880 


Gly Thr Met Pro Pro Gly Ile Ala Thr Val Thr Val Ile Val Lys Asp 
                885                 890                 895     


Met Asn Asp Tyr Pro Pro Val Phe Ser Lys Arg Ile Tyr Lys Gly Met 
            900                 905                 910         


Val Ala Pro Asp Ala Val Lys Gly Thr Pro Ile Thr Thr Val Tyr Ala 
        915                 920                 925             


Glu Asp Ala Asp Pro Pro Gly Leu Pro Ala Ser Arg Val Arg Tyr Arg 
    930                 935                 940                 


Val Asp Asp Val Gln Phe Pro Tyr Pro Ala Ser Ile Phe Glu Val Glu 
945                 950                 955                 960 


Glu Asp Ser Gly Arg Val Ile Thr Arg Val Asn Leu Asn Glu Glu Pro 
                965                 970                 975     


Thr Thr Ile Phe Lys Leu Val Val Val Ala Phe Asp Asp Gly Glu Pro 
            980                 985                 990         


Val Met Ser Ser Ser Ala Thr Val  Lys Ile Leu Val Leu  His Pro Gly 
        995                 1000                 1005             


Glu Ile  Pro Arg Phe Thr Gln  Glu Glu Tyr Arg Pro  Pro Pro Val 
    1010                 1015                 1020             


Ser Glu  Leu Ala Thr Lys Gly  Thr Met Val Gly Val  Ile Ser Ala 
    1025                 1030                 1035             


Ala Ala  Ile Asn Gln Ser Ile  Val Tyr Ser Ile Val  Ser Gly Asn 
    1040                 1045                 1050             


Glu Glu  Asp Thr Phe Gly Ile  Asn Asn Ile Thr Gly  Val Ile Tyr 
    1055                 1060                 1065             


Val Asn  Gly Pro Leu Asp Tyr  Glu Thr Arg Thr Ser  Tyr Val Leu 
    1070                 1075                 1080             


Arg Val  Gln Ala Asp Ser Leu  Glu Val Val Leu Ala  Asn Leu Arg 
    1085                 1090                 1095             


Val Pro  Ser Lys Ser Asn Thr  Ala Lys Val Tyr Ile  Glu Ile Gln 
    1100                 1105                 1110             


Asp Glu  Asn Asn His Pro Pro  Val Phe Gln Lys Lys  Phe Tyr Ile 
    1115                 1120                 1125             


Gly Gly  Val Ser Glu Asp Ala  Arg Met Phe Thr Ser  Val Leu Arg 
    1130                 1135                 1140             


Val Lys  Ala Thr Asp Lys Asp  Thr Gly Asn Tyr Ser  Val Met Ala 
    1145                 1150                 1155             


Tyr Arg  Leu Ile Ile Pro Pro  Ile Lys Glu Gly Lys  Glu Gly Phe 
    1160                 1165                 1170             


Val Val  Glu Thr Tyr Thr Gly  Leu Ile Lys Thr Ala  Met Leu Phe 
    1175                 1180                 1185             


His Asn  Met Arg Arg Ser Tyr  Phe Lys Phe Gln Val  Ile Ala Thr 
    1190                 1195                 1200             


Asp Asp  Tyr Gly Lys Gly Leu  Ser Gly Lys Ala Asp  Val Leu Val 
    1205                 1210                 1215             


Ser Val  Val Asn Gln Leu Asp  Met Gln Val Ile Val  Ser Asn Val 
    1220                 1225                 1230             


Pro Pro  Thr Leu Val Glu Lys  Lys Ile Glu Asp Leu  Thr Glu Ile 
    1235                 1240                 1245             


Leu Asp  Arg Tyr Val Gln Glu  Gln Ile Pro Gly Ala  Lys Val Val 
    1250                 1255                 1260             


Val Glu  Ser Ile Gly Ala Arg  Arg His Gly Asp Ala  Phe Ser Leu 
    1265                 1270                 1275             


Glu Asp  Tyr Thr Lys Cys Asp  Leu Thr Val Tyr Ala  Ile Asp Pro 
    1280                 1285                 1290             


Gln Thr  Asn Arg Ala Ile Asp  Arg Asn Glu Leu Phe  Lys Phe Leu 
    1295                 1300                 1305             


Asp Gly  Lys Leu Leu Asp Ile  Asn Lys Asp Phe Gln  Pro Tyr Tyr 
    1310                 1315                 1320             


Gly Glu  Gly Gly Arg Ile Leu  Glu Ile Arg Thr Pro  Glu Ala Val 
    1325                 1330                 1335             


Thr Ser  Ile Lys Lys Arg Gly  Glu Ser Leu Gly Tyr  Thr Glu Gly 
    1340                 1345                 1350             


Ala Leu  Leu Ala Leu Ala Phe  Ile Ile Ile Leu Cys  Cys Ile Pro 
    1355                 1360                 1365             


Ala Ile  Leu Val Val Leu Val  Ser Tyr Arg Gln Arg  Gln Ala Glu 
    1370                 1375                 1380             


Cys Thr  Lys Thr Ala Arg Ile  Gln Ala Ala Leu Pro  Ala Ala Lys 
    1385                 1390                 1395             


Pro Ala  Val Pro Ala Pro Ala  Pro Val Ala Ala Pro  Pro Pro Pro 
    1400                 1405                 1410             


Pro Pro  Pro Pro Pro Gly Ala  His Leu Tyr Glu Glu  Leu Gly Asp 
    1415                 1420                 1425             


Ser Ser  Met His Asn Leu Phe  Leu Leu Tyr His Phe  Gln Gln Ser 
    1430                 1435                 1440             


Arg Gly  Asn Asn Ser Val Ser  Glu Asp Arg Lys His  Gln Gln Val 
    1445                 1450                 1455             


Val Met  Pro Phe Ser Ser Asn  Thr Ile Glu Ala His  Lys Ser Ala 
    1460                 1465                 1470             


His Val  Asp Gly Ser Leu Lys  Ser Asn Lys Leu Lys  Ser Ala Arg 
    1475                 1480                 1485             


Lys Phe  Thr Phe Leu Ser Asp  Glu Asp Asp Leu Ser  Ala His Asn 
    1490                 1495                 1500             


Pro Leu  Tyr Lys Glu Asn Ile  Ser Gln Val Ser Thr  Asn Ser Asp 
    1505                 1510                 1515             


Ile Ser  Gln Arg Thr Asp Phe  Val Asp Pro Phe Ser  Pro Lys Ile 
    1520                 1525                 1530             


Gln Ala  Lys Ser Lys Ser Leu  Arg Gly Pro Arg Glu  Lys Ile Gln 
    1535                 1540                 1545             


Arg Leu  Trp Ser Gln Ser Val  Ser Leu Pro Arg Arg  Leu Met Arg 
    1550                 1555                 1560             


Lys Val  Pro Asn Arg Pro Glu  Ile Ile Asp Leu Gln  Gln Trp Gln 
    1565                 1570                 1575             


Gly Thr  Arg Gln Lys Ala Glu  Asn Glu Asn Thr Gly  Ile Cys Thr 
    1580                 1585                 1590             


Asn Lys  Arg Gly Ser Ser Asn  Pro Leu Leu Thr Thr  Glu Glu Ala 
    1595                 1600                 1605             


Asn Leu  Thr Glu Lys Glu Glu  Ile Arg Gln Gly Glu  Thr Leu Met 
    1610                 1615                 1620             


Ile Glu  Gly Thr Glu Gln Leu  Lys Ser Leu Ser Ser  Asp Ser Ser 
    1625                 1630                 1635             


Phe Cys  Phe Pro Arg Pro His  Phe Ser Phe Ser Thr  Leu Pro Thr 
    1640                 1645                 1650             


Val Ser  Arg Thr Val Glu Leu  Lys Ser Glu Pro Asn  Val Ile Ser 
    1655                 1660                 1665             


Ser Pro  Ala Glu Cys Ser Leu  Glu Leu Ser Pro Ser  Arg Pro Cys 
    1670                 1675                 1680             


Val Leu  His Ser Ser Leu Ser  Arg Arg Glu Thr Pro  Ile Cys Met 
    1685                 1690                 1695             


Leu Pro  Ile Glu Thr Glu Arg  Asn Ile Phe Glu Asn  Phe Ala His 
    1700                 1705                 1710             


Pro Pro  Asn Ile Ser Pro Ser  Ala Cys Pro Leu Pro  Pro Pro Pro 
    1715                 1720                 1725             


Pro Ile  Ser Pro Pro Ser Pro  Pro Pro Ala Pro Ala  Pro Leu Ala 
    1730                 1735                 1740             


Pro Pro  Pro Asp Ile Ser Pro  Phe Ser Leu Phe Cys  Pro Pro Pro 
    1745                 1750                 1755             


Ser Pro  Pro Ser Ile Pro Leu  Pro Leu Pro Pro Pro  Thr Phe Phe 
    1760                 1765                 1770             


Pro Leu  Ser Val Ser Thr Ser  Gly Pro Pro Thr Pro  Pro Leu Leu 
    1775                 1780                 1785             


Pro Pro  Phe Pro Thr Pro Leu  Pro Pro Pro Pro Pro  Ser Ile Pro 
    1790                 1795                 1800             


Cys Pro  Pro Pro Pro Ser Ala  Ser Phe Leu Ser Thr  Glu Cys Val 
    1805                 1810                 1815             


Cys Ile  Thr Gly Val Lys Cys  Thr Thr Asn Leu Met  Pro Ala Glu 
    1820                 1825                 1830             


Lys Ile  Lys Ser Ser Met Thr  Gln Leu Ser Thr Thr  Thr Val Cys 
    1835                 1840                 1845             


Lys Thr  Asp Pro Gln Arg Glu  Pro Lys Gly Ile Leu  Arg His Val 
    1850                 1855                 1860             


Lys Asn  Leu Ala Glu Leu Glu  Lys Ser Val Ala Asn  Met Tyr Ser 
    1865                 1870                 1875             


Gln Ile  Glu Lys Asn Tyr Leu  Arg Thr Asn Val Ser  Glu Leu Gln 
    1880                 1885                 1890             


Thr Met  Cys Pro Ser Glu Val  Thr Asn Met Glu Ile  Thr Ser Glu 
    1895                 1900                 1905             


Gln Asn  Lys Gly Ser Leu Asn  Asn Ile Val Glu Gly  Thr Glu Lys 
    1910                 1915                 1920             


Gln Ser  His Ser Gln Ser Thr  Ser Leu 
    1925                 1930         


<210>  1699
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  1699

Met Ala Asp Ser Ala Gln Ala Gln Lys Leu Val Tyr Leu Val Thr Gly 
1               5                   10                  15      


Gly Cys Gly Phe Leu Gly Glu His Val Val Arg Met Leu Leu Gln Arg 
            20                  25                  30          


Glu Pro Arg Leu Gly Glu Leu Arg Val Phe Asp Gln His Leu Gly Pro 
        35                  40                  45              


Trp Leu Glu Glu Leu Lys Thr Gly Pro Val Arg Val Thr Ala Ile Gln 
    50                  55                  60                  


Gly Asp Val Thr Gln Ala His Glu Val Ala Ala Ala Val Ala Gly Ala 
65                  70                  75                  80  


His Val Val Ile His Thr Ala Gly Leu Val Asp Val Phe Gly Arg Ala 
                85                  90                  95      


Ser Pro Lys Thr Ile His Glu Val Asn Val Gln Gly Thr Arg Asn Val 
            100                 105                 110         


Ile Glu Ala Cys Val Gln Thr Gly Thr Arg Phe Leu Val Tyr Thr Ser 
        115                 120                 125             


Ser Met Glu Val Val Gly Pro Asn Thr Lys Gly His Pro Phe Tyr Arg 
    130                 135                 140                 


Gly Asn Glu Asp Thr Pro Tyr Glu Ala Val His Arg His Pro Tyr Pro 
145                 150                 155                 160 


Cys Ser Lys Ala Leu Ala Glu Trp Leu Val Leu Glu Ala Asn Gly Arg 
                165                 170                 175     


Lys Ala Met Leu Pro Gly Cys Thr Cys Trp Gln Pro Gly Ser Trp Ser 
            180                 185                 190         


Ser Gly Gln Pro 
        195     


<210>  1700
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  1700

Met Ala Asp Ser Ala Gln Ala Gln Lys Leu Val Tyr Leu Val Thr Gly 
1               5                   10                  15      


Gly Cys Gly Phe Leu Gly Glu His Val Val Arg Met Leu Leu Gln Arg 
            20                  25                  30          


Glu Pro Arg Leu Gly Glu Leu Arg Val Phe Asp Gln His Leu Gly Pro 
        35                  40                  45              


Trp Leu Glu Glu Leu Lys Thr Gly Pro Val Arg Val Thr Ala Ile Gln 
    50                  55                  60                  


Gly Asp Val Thr Gln Ala His Glu Val Ala Ala Ala Val Ala Gly Ala 
65                  70                  75                  80  


His Val Val Ile His Thr Ala Gly Leu Val Asp Val Phe Gly Arg Ala 
                85                  90                  95      


Ser Pro Lys Thr Ile His Glu Val Asn Val Gln Gly Thr Arg Asn Val 
            100                 105                 110         


Ile Glu Ala Cys Val Gln Thr Gly Thr Arg Phe Leu Val Tyr Thr Ser 
        115                 120                 125             


Ser Met Glu Val Val Gly Pro Asn Thr Lys Gly His Pro Phe Tyr Arg 
    130                 135                 140                 


Gly Asn Glu Asp Thr Pro Tyr Glu Ala Val His Arg His Pro Tyr Pro 
145                 150                 155                 160 


Cys Ser Lys Ala Leu Ala Glu Trp Leu Val Leu Glu Ala Asn Gly Arg 
                165                 170                 175     


Lys Ala Met Leu Pro Gly Cys Thr Cys Trp Gln Pro Gly Ser Trp Ser 
            180                 185                 190         


Ser Gly Gln Pro 
        195     


<210>  1701
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  1701

Met Ser Ser Ser Cys Ser Gly Leu Ser Arg Val Leu Val Ala Val Ala 
1               5                   10                  15      


Thr Ala Leu Val Ser Ala Ser Ser Pro Cys Pro Gln Ala Trp Gly Pro 
            20                  25                  30          


Pro Gly Val Gln Tyr Gly Gln Pro Gly Arg Ser Val Lys Leu Cys Cys 
        35                  40                  45              


Pro Gly Val Thr Ala Gly Asp Pro Val Ser Trp Phe Arg Asp Gly Glu 
    50                  55                  60                  


Pro Lys Leu Leu Gln Gly Pro Asp Ser Gly Leu Gly His Glu Leu Val 
65                  70                  75                  80  


Leu Ala Gln Ala Asp Ser Thr Asp Glu Gly Thr Tyr Ile Cys Gln Thr 
                85                  90                  95      


Leu Asp Gly Ala Leu Gly Gly Thr Val Thr Leu Gln Leu Gly Tyr Pro 
            100                 105                 110         


Pro Ala Arg Pro Val Val Ser Cys Gln Ala Ala Asp Tyr Glu Asn Phe 
        115                 120                 125             


Ser Cys Thr Trp Ser Pro Ser Gln Ile Ser Gly Leu Pro Thr Arg Tyr 
    130                 135                 140                 


Leu Thr Ser Tyr Arg Lys Lys Thr Val Leu Gly Ala Asp Ser Gln Arg 
145                 150                 155                 160 


Arg Ser Pro Ser Thr Gly Pro Trp Pro Cys Pro Gln Asp Pro Leu Gly 
                165                 170                 175     


Ala Ala Arg Cys Val Val His Gly Ala Glu Phe Trp Ser Gln Tyr Arg 
            180                 185                 190         


Ile Asn Val Thr Glu Val Asn Pro Leu Gly Ala Ser Thr Arg Leu Leu 
        195                 200                 205             


Asp Val Ser Leu Gln Ser Ile Leu Arg Pro Asp Pro Pro Gln Gly Leu 
    210                 215                 220                 


Arg Val Glu Ser Val Pro Gly Tyr Pro Arg Arg Leu Arg Ala Ser Trp 
225                 230                 235                 240 


Thr Tyr Pro Ala Ser Trp Pro Cys Gln Pro His Phe Leu Leu Lys Phe 
                245                 250                 255     


Arg Leu Gln Tyr Arg Pro Ala Gln His Pro Ala Trp Ser Thr Val Glu 
            260                 265                 270         


Pro Ala Gly Leu Glu Glu Val Ile Thr Asp Ala Val Ala Gly Leu Pro 
        275                 280                 285             


His Ala Val Arg Val Ser Ala Arg Asp Phe Leu Asp Ala Gly Thr Trp 
    290                 295                 300                 


Ser Thr Trp Ser Pro Glu Ala Trp Gly Thr Pro Ser Thr Gly Thr Ile 
305                 310                 315                 320 


Pro Lys Glu Ile Pro Ala Trp Gly Gln Leu His Thr Gln Pro Glu Val 
                325                 330                 335     


Glu Pro Gln Val Asp Ser Pro Ala Pro Pro Arg Pro Ser Leu Gln Pro 
            340                 345                 350         


His Pro Arg Leu Leu Asp His Arg Asp Ser Val Glu Gln Val Ala Val 
        355                 360                 365             


Leu Ala Ser Leu Gly Ile Leu Ser Phe Leu Gly Leu Val Ala Gly Ala 
    370                 375                 380                 


Leu Ala Leu Gly Leu Trp Leu Arg Leu Arg Arg Gly Gly Lys Asp Gly 
385                 390                 395                 400 


Ser Pro Lys Pro Gly Phe Leu Ala Ser Val Ile Pro Val Asp Arg Arg 
                405                 410                 415     


Pro Gly Ala Pro Asn Leu 
            420         


<210>  1702
<211>  775
<212>  PRT
<213>  Homo sapiens

<400>  1702

Met Asp Cys Arg Thr Lys Ala Asn Pro Asp Arg Thr Phe Asp Leu Val 
1               5                   10                  15      


Leu Lys Val Lys Cys His Ala Ser Glu Asn Glu Asp Pro Val Val Leu 
            20                  25                  30          


Trp Lys Phe Pro Glu Asp Phe Gly Asp Gln Glu Ile Leu Gln Ser Val 
        35                  40                  45              


Pro Lys Phe Cys Phe Pro Phe Asp Val Glu Arg Val Ser Gln Asn Gln 
    50                  55                  60                  


Val Gly Gln His Phe Thr Phe Val Leu Thr Asp Ile Glu Ser Lys Gln 
65                  70                  75                  80  


Arg Phe Gly Phe Cys Arg Leu Thr Ser Gly Gly Thr Ile Cys Leu Cys 
                85                  90                  95      


Ile Leu Ser Tyr Leu Pro Trp Phe Glu Val Tyr Tyr Lys Leu Leu Asn 
            100                 105                 110         


Thr Leu Ala Asp Tyr Leu Ala Lys Glu Leu Glu Asn Asp Leu Asn Glu 
        115                 120                 125             


Thr Leu Arg Ser Leu Tyr Asn His Pro Val Pro Lys Ala Asn Thr Pro 
    130                 135                 140                 


Val Asn Leu Ser Val Asn Gln Glu Ile Phe Ile Ala Cys Glu Gln Val 
145                 150                 155                 160 


Leu Lys Asp Gln Pro Ala Leu Val Pro His Ser Tyr Phe Ile Ala Pro 
                165                 170                 175     


Asp Val Thr Gly Leu Pro Thr Ile Pro Glu Ser Arg Asn Leu Thr Glu 
            180                 185                 190         


Tyr Phe Val Ala Val Asp Val Asn Asn Met Leu Gln Leu Tyr Ala Ser 
        195                 200                 205             


Met Leu His Glu Arg Arg Ile Val Ile Ile Ser Ser Lys Leu Ser Thr 
    210                 215                 220                 


Leu Thr Ala Cys Ile His Gly Ser Ala Ala Leu Leu Tyr Pro Met Tyr 
225                 230                 235                 240 


Trp Gln His Ile Tyr Ile Pro Val Leu Pro Pro His Leu Leu Asp Tyr 
                245                 250                 255     


Cys Cys Ala Pro Met Pro Tyr Leu Ile Gly Ile His Ser Ser Leu Ile 
            260                 265                 270         


Glu Arg Val Lys Asn Lys Ser Leu Glu Asp Val Val Met Leu Asn Val 
        275                 280                 285             


Asp Thr Asn Thr Leu Glu Ser Pro Phe Ser Asp Leu Asn Asn Leu Pro 
    290                 295                 300                 


Ser Asp Val Val Ser Ala Leu Lys Asn Lys Leu Lys Lys Gln Ser Thr 
305                 310                 315                 320 


Ala Thr Gly Asp Gly Val Ala Arg Ala Phe Leu Arg Ala Gln Ala Ala 
                325                 330                 335     


Leu Phe Gly Ser Tyr Arg Asp Ala Leu Arg Tyr Lys Pro Gly Glu Pro 
            340                 345                 350         


Ile Thr Phe Cys Glu Glu Ser Phe Val Lys His Arg Ser Ser Val Met 
        355                 360                 365             


Lys Gln Phe Leu Glu Thr Ala Ile Asn Leu Gln Leu Phe Lys Gln Phe 
    370                 375                 380                 


Ile Asp Gly Arg Leu Ala Lys Leu Asn Ala Gly Arg Gly Phe Ser Asp 
385                 390                 395                 400 


Val Phe Glu Glu Glu Ile Thr Ser Gly Gly Phe Cys Gly Gly Asn Pro 
                405                 410                 415     


Arg Ser Tyr Gln Gln Trp Val His Thr Val Lys Lys Gly Gly Ala Leu 
            420                 425                 430         


Phe Asn Thr Ala Met Thr Lys Ala Thr Pro Ala Val Arg Thr Ala Tyr 
        435                 440                 445             


Lys Phe Ala Lys Asn His Ala Lys Leu Gly Leu Lys Glu Val Lys Ser 
    450                 455                 460                 


Lys Leu Lys His Lys Glu Asn Glu Glu Asp Tyr Gly Thr Cys Ser Ser 
465                 470                 475                 480 


Ser Val Gln Tyr Thr Pro Val Tyr Lys Leu His Asn Glu Lys Gly Gly 
                485                 490                 495     


Asn Ser Glu Lys Arg Lys Leu Ala Gln Ala Arg Leu Lys Arg Pro Leu 
            500                 505                 510         


Lys Ser Leu Asp Gly Ala Leu Tyr Asp Asp Glu Asp Asp Asp Asp Ile 
        515                 520                 525             


Glu Arg Ala Ser Lys Leu Ser Ser Glu Asp Gly Glu Glu Ala Ser Ala 
    530                 535                 540                 


Tyr Leu Tyr Glu Ser Asp Asp Ser Val Glu Thr Arg Val Lys Thr Pro 
545                 550                 555                 560 


Tyr Ser Gly Glu Met Asp Leu Leu Gly Glu Ile Leu Asp Thr Leu Ser 
                565                 570                 575     


Thr His Ser Ser Asp Gln Gly Lys Leu Ala Ala Ala Lys Ser Leu Asp 
            580                 585                 590         


Phe Phe Arg Ser Met Asp Asp Ile Asp Tyr Lys Pro Thr Asn Lys Ser 
        595                 600                 605             


Asn Ala Pro Ser Glu Asn Asn Leu Ala Phe Leu Cys Gly Gly Ser Gly 
    610                 615                 620                 


Asp Gln Ala Glu Trp Asn Leu Gly Gln Asp Asp Ser Ala Leu His Gly 
625                 630                 635                 640 


Lys His Leu Pro Pro Ser Pro Arg Lys Arg Val Ser Ser Ser Gly Leu 
                645                 650                 655     


Thr Asp Ser Leu Phe Ile Leu Lys Glu Glu Asn Ser Asn Lys His Leu 
            660                 665                 670         


Gly Ala Asp Asn Val Ser Asp Pro Thr Ser Gly Leu Asp Phe Gln Leu 
        675                 680                 685             


Thr Ser Pro Glu Val Ser Gln Thr Asp Lys Gly Lys Thr Glu Lys Arg 
    690                 695                 700                 


Glu Thr Leu Ser Gln Ile Ser Asp Asp Leu Leu Ile Pro Gly Leu Gly 
705                 710                 715                 720 


Arg His Ser Ser Thr Phe Val Pro Trp Glu Lys Glu Gly Lys Glu Ala 
                725                 730                 735     


Lys Glu Thr Ser Glu Asp Ile Gly Leu Leu His Glu Val Val Ser Leu 
            740                 745                 750         


Cys His Met Thr Ser Asp Phe Gln Gln Ser Leu Asn Ile Ser Asp Lys 
        755                 760                 765             


Asn Thr Asn Gly Asn Gln Thr 
    770                 775 


<210>  1703
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  1703

Met Glu Leu Arg Lys Tyr Gly Pro Gly Arg Leu Ala Gly Thr Val Ile 
1               5                   10                  15      


Gly Gly Ala Ala Gln Ser Lys Ser Gln Thr Lys Ser Asp Ser Ile Thr 
            20                  25                  30          


Lys Glu Phe Leu Pro Gly Leu Tyr Thr Ala Pro Ser Ser Pro Phe Pro 
        35                  40                  45              


Pro Ser Gln Val Ser Asp His Gln Val Leu Asn Asp Ala Glu Val Ala 
    50                  55                  60                  


Ala Leu Leu Glu Asn Phe Ser Ser Ser Tyr Asp Tyr Gly Glu Asn Glu 
65                  70                  75                  80  


Ser Asp Ser Cys Cys Thr Ser Pro Pro Cys Pro Gln Asp Phe Ser Leu 
                85                  90                  95      


Asn Phe Asp Arg Ala Phe Leu Pro Ala Leu Tyr Ser Leu Leu Phe Leu 
            100                 105                 110         


Leu Gly Leu Leu Gly Asn Gly Ala Val Ala Ala Val Leu Leu Ser Arg 
        115                 120                 125             


Arg Thr Ala Leu Ser Ser Thr Asp Thr Phe Leu Leu His Leu Ala Val 
    130                 135                 140                 


Ala Asp Thr Leu Leu Val Leu Thr Leu Pro Leu Trp Ala Val Asp Ala 
145                 150                 155                 160 


Ala Val Gln Trp Val Phe Gly Ser Gly Leu Cys Lys Val Ala Gly Ala 
                165                 170                 175     


Leu Phe Asn Ile Asn Phe Tyr Ala Gly Ala Leu Leu Leu Ala Cys Ile 
            180                 185                 190         


Ser Phe Asp Arg Tyr Leu Asn Ile Val His Ala Thr Gln Leu Tyr Arg 
        195                 200                 205             


Arg Gly Pro Pro Ala Arg Val Thr Leu Thr Cys Leu Ala Val Trp Gly 
    210                 215                 220                 


Leu Cys Leu Leu Phe Ala Leu Pro Asp Phe Ile Phe Leu Ser Ala His 
225                 230                 235                 240 


His Asp Glu Arg Leu Asn Ala Thr His Cys Gln Tyr Asn Phe Pro Gln 
                245                 250                 255     


Val Gly Arg Thr Ala Leu Arg Val Leu Gln Leu Val Ala Gly Phe Leu 
            260                 265                 270         


Leu Pro Leu Leu Val Met Ala Tyr Cys Tyr Ala His Ile Leu Ala Val 
        275                 280                 285             


Leu Leu Val Ser Arg Gly Gln Arg Arg Leu Arg Ala Met Arg Leu Val 
    290                 295                 300                 


Val Val Val Val Val Ala Phe Ala Leu Cys Trp Thr Pro Tyr His Leu 
305                 310                 315                 320 


Val Val Leu Val Asp Ile Leu Met Asp Leu Gly Ala Leu Ala Arg Asn 
                325                 330                 335     


Cys Gly Arg Glu Ser Arg Val Asp Val Ala Lys Ser Val Thr Ser Gly 
            340                 345                 350         


Leu Gly Tyr Met His Cys Cys Leu Asn Pro Leu Leu Tyr Ala Phe Val 
        355                 360                 365             


Gly Val Lys Phe Arg Glu Arg Met Trp Met Leu Leu Leu Arg Leu Gly 
    370                 375                 380                 


Cys Pro Asn Gln Arg Gly Leu Gln Arg Gln Pro Ser Ser Ser Arg Arg 
385                 390                 395                 400 


Asp Ser Ser Trp Ser Glu Thr Ser Glu Ala Ser Tyr Ser Gly Leu 
                405                 410                 415 


<210>  1704
<211>  625
<212>  PRT
<213>  Homo sapiens

<400>  1704

Met Ala Lys Lys Ser Ala Glu Asn Gly Ile Tyr Ser Val Ser Gly Asp 
1               5                   10                  15      


Glu Lys Lys Gly Pro Leu Ile Ala Pro Gly Pro Asp Gly Ala Pro Ala 
            20                  25                  30          


Lys Gly Asp Gly Pro Val Gly Leu Gly Thr Pro Gly Gly Arg Leu Ala 
        35                  40                  45              


Val Pro Pro Arg Glu Thr Trp Thr Arg Gln Met Asp Phe Ile Met Ser 
    50                  55                  60                  


Cys Val Gly Phe Ala Val Gly Leu Gly Asn Val Trp Arg Phe Pro Tyr 
65                  70                  75                  80  


Leu Cys Tyr Lys Asn Gly Gly Gly Val Phe Leu Ile Pro Tyr Val Leu 
                85                  90                  95      


Ile Ala Leu Val Gly Gly Ile Pro Ile Phe Phe Leu Glu Ile Ser Leu 
            100                 105                 110         


Gly Gln Phe Met Lys Ala Gly Ser Ile Asn Val Trp Asn Ile Cys Pro 
        115                 120                 125             


Leu Phe Lys Gly Leu Gly Tyr Ala Ser Met Val Ile Val Phe Tyr Cys 
    130                 135                 140                 


Asn Thr Tyr Tyr Ile Met Val Leu Ala Trp Gly Phe Tyr Tyr Leu Val 
145                 150                 155                 160 


Lys Ser Phe Thr Thr Thr Leu Pro Trp Ala Thr Cys Gly His Thr Trp 
                165                 170                 175     


Asn Thr Pro Asp Cys Val Glu Ile Phe Arg His Glu Asp Cys Ala Asn 
            180                 185                 190         


Ala Ser Leu Ala Asn Leu Thr Cys Asp Gln Leu Ala Asp Arg Arg Ser 
        195                 200                 205             


Pro Val Ile Glu Phe Trp Glu Asn Lys Val Leu Arg Leu Ser Gly Gly 
    210                 215                 220                 


Leu Glu Val Pro Gly Ala Leu Asn Trp Glu Val Thr Leu Cys Leu Leu 
225                 230                 235                 240 


Ala Cys Trp Val Leu Val Tyr Phe Cys Val Trp Lys Gly Val Lys Ser 
                245                 250                 255     


Thr Gly Lys Ile Val Tyr Phe Thr Ala Thr Phe Pro Tyr Val Val Leu 
            260                 265                 270         


Val Val Leu Leu Val Arg Gly Val Leu Leu Pro Gly Ala Leu Asp Gly 
        275                 280                 285             


Ile Ile Tyr Tyr Leu Lys Pro Asp Trp Ser Lys Leu Gly Ser Pro Gln 
    290                 295                 300                 


Val Trp Ile Asp Ala Gly Thr Gln Ile Phe Phe Ser Tyr Ala Ile Gly 
305                 310                 315                 320 


Leu Gly Ala Leu Thr Ala Leu Gly Ser Tyr Asn Arg Phe Asn Asn Asn 
                325                 330                 335     


Cys Tyr Asn Gly Thr Ser Phe Phe Ala Gly Phe Val Val Phe Ser Ile 
            340                 345                 350         


Leu Gly Phe Met Ala Ala Glu Gln Gly Val His Ile Ser Lys Val Ala 
        355                 360                 365             


Glu Ser Gly Pro Gly Leu Ala Phe Ile Ala Tyr Pro Arg Ala Val Thr 
    370                 375                 380                 


Leu Met Pro Val Ala Pro Leu Trp Ala Ala Leu Phe Phe Phe Met Leu 
385                 390                 395                 400 


Leu Leu Leu Gly Leu Asp Ser Gln Phe Val Gly Val Glu Gly Phe Ile 
                405                 410                 415     


Thr Gly Leu Leu Asp Leu Leu Pro Ala Ser Tyr Tyr Phe Arg Phe Gln 
            420                 425                 430         


Arg Glu Ile Ser Val Ala Leu Cys Cys Ala Leu Cys Phe Val Ile Asp 
        435                 440                 445             


Leu Ser Met Val Thr Asp Gly Gly Met Tyr Val Phe Gln Leu Phe Asp 
    450                 455                 460                 


Tyr Tyr Ser Ala Ser Gly Thr Thr Leu Leu Trp Gln Ala Phe Trp Glu 
465                 470                 475                 480 


Cys Val Val Val Ala Trp Val Tyr Gly Ala Asp Arg Phe Met Asp Asp 
                485                 490                 495     


Ile Ala Cys Met Ile Gly Tyr Arg Pro Cys Pro Trp Met Lys Trp Cys 
            500                 505                 510         


Trp Ser Phe Phe Thr Pro Leu Val Cys Met Gly Ile Phe Ile Phe Asn 
        515                 520                 525             


Val Val Tyr Tyr Glu Pro Leu Val Tyr Asn Asn Thr Tyr Val Tyr Pro 
    530                 535                 540                 


Trp Trp Gly Glu Ala Met Gly Trp Ala Phe Ala Leu Ser Ser Met Leu 
545                 550                 555                 560 


Cys Val Pro Leu His Leu Leu Gly Cys Leu Leu Arg Ala Lys Gly Thr 
                565                 570                 575     


Met Ala Glu Arg Trp Gln His Leu Thr Gln Pro Ile Trp Gly Leu His 
            580                 585                 590         


His Leu Glu Tyr Arg Ala Gln Asp Ala Asp Val Arg Gly Leu Thr Thr 
        595                 600                 605             


Leu Thr Pro Val Ser Glu Ser Ser Lys Val Val Val Val Glu Ser Val 
    610                 615                 620                 


Met 
625 


<210>  1705
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  1705

Met Lys Ala Gly Ser Ile Asn Val Trp Asn Ile Cys Pro Leu Phe Lys 
1               5                   10                  15      


Gly Leu Gly Tyr Ala Ser Met Val Ile Val Phe Tyr Cys Asn Thr Tyr 
            20                  25                  30          


Tyr Ile Met Val Leu Ala Trp Gly Phe Tyr Tyr Leu Val Lys Ser Phe 
        35                  40                  45              


Thr Thr Thr Leu Pro Trp Ala Thr Cys Gly His Thr Trp Asn Thr Pro 
    50                  55                  60                  


Asp Cys Val Glu Ile Phe Arg His Glu Asp Cys Ala Asn Ala Ser Leu 
65                  70                  75                  80  


Ala Asn Leu Thr Cys Asp Gln Leu Ala Asp Arg Arg Ser Pro Val Ile 
                85                  90                  95      


Glu Phe Trp Glu Asn Lys Val Leu Arg Leu Ser Gly Gly Leu Glu Val 
            100                 105                 110         


Pro Gly Ala Leu Asn Trp Glu Val Thr Leu Cys Leu Leu Ala Cys Trp 
        115                 120                 125             


Val Leu Val Tyr Phe Cys Val Trp Lys Gly Val Lys Ser Thr Gly Lys 
    130                 135                 140                 


Ile Val Tyr Phe Thr Ala Thr Phe Pro Tyr Val Val Leu Val Val Leu 
145                 150                 155                 160 


Leu Val Arg Gly Val Leu Leu Pro Gly Ala Leu Asp Gly Ile Ile Tyr 
                165                 170                 175     


Tyr Leu Lys Pro Asp Trp Ser Lys Leu Gly Ser Pro Gln Val Trp Ile 
            180                 185                 190         


Asp Ala Gly Thr Gln Ile Phe Phe Ser Tyr Ala Ile Gly Leu Gly Ala 
        195                 200                 205             


Leu Thr Ala Leu Gly Ser Tyr Asn Arg Phe Asn Asn Asn Cys Tyr Lys 
    210                 215                 220                 


Asp Ala Ile Ile Leu Ala Leu Ile Asn Ser Gly Thr Ser Phe Phe Ala 
225                 230                 235                 240 


Gly Phe Val Val Phe Ser Ile Leu Gly Phe Met Ala Ala Glu Gln Gly 
                245                 250                 255     


Val His Ile Ser Lys Val Ala Glu Ser Gly Pro Gly Leu Ala Phe Ile 
            260                 265                 270         


Ala Tyr Pro Arg Ala Val Thr Leu Met Pro Val Ala Pro Leu Trp Ala 
        275                 280                 285             


Ala Leu Phe Phe Phe Met Leu Leu Leu Leu Gly Leu Asp Ser Gln Phe 
    290                 295                 300                 


Val Gly Val Glu Gly Phe Ile Thr Gly Leu Leu Asp Leu Leu Pro Ala 
305                 310                 315                 320 


Ser Tyr Tyr Phe Arg Phe Gln Arg Glu Ile Ser Val Ala Leu Cys Cys 
                325                 330                 335     


Ala Leu Cys Phe Val Ile Asp Leu Ser Met Val Thr Asp Gly Gly Met 
            340                 345                 350         


Tyr Val Phe Gln Leu Phe Asp Tyr Tyr Ser Ala Ser Gly Thr Thr Leu 
        355                 360                 365             


Leu Trp Gln Ala Phe Trp Glu Cys Val Val Val Ala Trp Val Tyr Gly 
    370                 375                 380                 


Ala Asp Arg Phe Met Asp Asp Ile Ala Cys Met Ile Gly Tyr Arg Pro 
385                 390                 395                 400 


Cys Pro Trp Met Lys Trp Cys Trp Ser Phe Phe Thr Pro Leu Val Cys 
                405                 410                 415     


Met Gly Ile Phe Ile Phe Asn Val Val Tyr Tyr Glu Pro Leu Val Tyr 
            420                 425                 430         


Asn Asn Thr Tyr Val Tyr Pro Trp Trp Gly Glu Ala Met Gly Trp Ala 
        435                 440                 445             


Phe Ala Leu Ser Ser Met Leu Cys Val Pro Leu His Leu Leu Gly Cys 
    450                 455                 460                 


Leu Leu Arg Ala Lys Gly Thr Met Ala Glu Arg Trp Gln His Leu Thr 
465                 470                 475                 480 


Gln Pro Ile Trp Gly Leu His His Leu Glu Tyr Arg Ala Gln Asp Ala 
                485                 490                 495     


Asp Val Arg Gly Leu Thr Thr Leu Thr Pro Val Ser Glu Ser Ser Lys 
            500                 505                 510         


Val Val Val Val Glu Ser Val Met 
        515                 520 


<210>  1706
<211>  2521
<212>  PRT
<213>  Homo sapiens

<400>  1706

Met Glu Pro His Val Leu Gly Ala Val Leu Tyr Trp Leu Leu Leu Pro 
1               5                   10                  15      


Cys Ala Leu Leu Ala Ala Cys Leu Leu Arg Phe Ser Gly Leu Ser Leu 
            20                  25                  30          


Val Tyr Leu Leu Phe Leu Leu Leu Leu Pro Trp Phe Pro Gly Pro Thr 
        35                  40                  45              


Arg Cys Gly Leu Gln Gly His Thr Gly Arg Leu Leu Arg Ala Leu Leu 
    50                  55                  60                  


Gly Leu Ser Leu Leu Phe Leu Val Ala His Leu Ala Leu Gln Ile Cys 
65                  70                  75                  80  


Leu His Ile Val Pro Arg Leu Asp Gln Leu Leu Gly Pro Ser Cys Ser 
                85                  90                  95      


Arg Trp Glu Thr Leu Ser Arg His Ile Gly Val Thr Arg Leu Asp Leu 
            100                 105                 110         


Lys Asp Ile Pro Asn Ala Ile Arg Leu Val Ala Pro Asp Leu Gly Ile 
        115                 120                 125             


Leu Val Val Ser Ser Val Cys Leu Gly Ile Cys Gly Arg Leu Ala Arg 
    130                 135                 140                 


Asn Thr Arg Gln Ser Pro His Pro Arg Glu Leu Asp Asp Asp Glu Arg 
145                 150                 155                 160 


Asp Val Asp Ala Ser Pro Thr Ala Gly Leu Gln Glu Ala Ala Thr Leu 
                165                 170                 175     


Ala Pro Thr Arg Arg Ser Arg Leu Ala Ala Arg Phe Arg Val Thr Ala 
            180                 185                 190         


His Trp Leu Leu Val Ala Ala Gly Arg Val Leu Ala Val Thr Leu Leu 
        195                 200                 205             


Ala Leu Ala Gly Ile Ala His Pro Ser Ala Leu Ser Ser Val Tyr Leu 
    210                 215                 220                 


Leu Leu Phe Leu Ala Leu Cys Thr Trp Trp Ala Cys His Phe Pro Ile 
225                 230                 235                 240 


Ser Thr Arg Gly Phe Ser Arg Leu Cys Val Ala Val Gly Cys Phe Gly 
                245                 250                 255     


Ala Gly His Leu Ile Cys Leu Tyr Cys Tyr Gln Met Pro Leu Ala Gln 
            260                 265                 270         


Ala Leu Leu Pro Pro Ala Gly Ile Trp Ala Arg Val Leu Gly Leu Lys 
        275                 280                 285             


Asp Phe Val Gly Pro Thr Asn Cys Ser Ser Pro His Ala Leu Val Leu 
    290                 295                 300                 


Asn Thr Gly Leu Asp Trp Pro Val Tyr Ala Ser Pro Gly Val Leu Leu 
305                 310                 315                 320 


Leu Leu Cys Tyr Ala Thr Ala Ser Leu Arg Lys Leu Arg Ala Tyr Arg 
                325                 330                 335     


Pro Ser Gly Gln Arg Lys Glu Ala Ala Lys Gly Tyr Glu Ala Arg Glu 
            340                 345                 350         


Leu Glu Leu Ala Glu Leu Asp Gln Trp Pro Gln Glu Arg Glu Ser Asp 
        355                 360                 365             


Gln His Val Val Pro Thr Ala Pro Asp Thr Glu Ala Asp Asn Cys Ile 
    370                 375                 380                 


Val His Glu Leu Thr Gly Gln Ser Ser Val Leu Arg Arg Pro Val Arg 
385                 390                 395                 400 


Pro Lys Arg Ala Glu Pro Arg Glu Ala Ser Pro Leu His Ser Leu Gly 
                405                 410                 415     


His Leu Ile Met Asp Gln Ser Tyr Val Cys Ala Leu Ile Ala Met Met 
            420                 425                 430         


Val Trp Ser Ile Thr Tyr His Ser Trp Leu Thr Phe Val Leu Leu Leu 
        435                 440                 445             


Trp Ala Cys Leu Ile Trp Thr Val Arg Ser Arg His Gln Leu Ala Met 
    450                 455                 460                 


Leu Cys Ser Pro Cys Ile Leu Leu Tyr Gly Met Thr Leu Cys Cys Leu 
465                 470                 475                 480 


Arg Tyr Val Trp Ala Met Asp Leu Arg Pro Glu Leu Pro Thr Thr Leu 
                485                 490                 495     


Gly Pro Val Ser Leu Arg Gln Leu Gly Leu Glu His Thr Arg Tyr Pro 
            500                 505                 510         


Cys Leu Asp Leu Gly Ala Met Leu Leu Tyr Thr Leu Thr Phe Trp Leu 
        515                 520                 525             


Leu Leu Arg Gln Phe Val Lys Glu Lys Leu Leu Lys Trp Ala Glu Ser 
    530                 535                 540                 


Pro Ala Ala Leu Thr Glu Val Thr Val Ala Asp Thr Glu Pro Thr Arg 
545                 550                 555                 560 


Thr Gln Thr Leu Leu Gln Ser Leu Gly Glu Leu Val Lys Gly Val Tyr 
                565                 570                 575     


Ala Lys Tyr Trp Ile Tyr Val Cys Ala Gly Met Phe Ile Val Val Ser 
            580                 585                 590         


Phe Ala Gly Arg Leu Val Val Tyr Lys Ile Val Tyr Met Phe Leu Phe 
        595                 600                 605             


Leu Leu Cys Leu Thr Leu Phe Gln Val Tyr Tyr Ser Leu Trp Arg Lys 
    610                 615                 620                 


Leu Leu Lys Ala Phe Trp Trp Leu Val Val Ala Tyr Thr Met Leu Val 
625                 630                 635                 640 


Leu Ile Ala Val Tyr Thr Phe Gln Phe Gln Asp Phe Pro Ala Tyr Trp 
                645                 650                 655     


Arg Asn Leu Thr Gly Phe Thr Asp Glu Gln Leu Gly Asp Leu Gly Leu 
            660                 665                 670         


Glu Gln Phe Ser Val Ser Glu Leu Phe Ser Ser Ile Leu Val Pro Gly 
        675                 680                 685             


Phe Phe Leu Leu Ala Cys Ile Leu Gln Leu His Tyr Phe His Arg Pro 
    690                 695                 700                 


Phe Met Gln Leu Thr Asp Met Glu His Val Ser Leu Pro Gly Thr Arg 
705                 710                 715                 720 


Leu Pro Arg Trp Ala His Arg Gln Asp Ala Val Ser Gly Thr Pro Leu 
                725                 730                 735     


Leu Arg Glu Glu Gln Gln Glu His Gln Gln Gln Gln Gln Glu Glu Glu 
            740                 745                 750         


Glu Glu Glu Glu Asp Ser Arg Asp Glu Gly Leu Gly Val Ala Thr Pro 
        755                 760                 765             


His Gln Ala Thr Gln Val Pro Glu Gly Ala Ala Lys Trp Gly Leu Val 
    770                 775                 780                 


Ala Glu Arg Leu Leu Glu Leu Ala Ala Gly Phe Ser Asp Val Leu Ser 
785                 790                 795                 800 


Arg Val Gln Val Phe Leu Arg Arg Leu Leu Glu Leu His Val Phe Lys 
                805                 810                 815     


Leu Val Ala Leu Tyr Thr Val Trp Val Ala Leu Lys Glu Val Ser Val 
            820                 825                 830         


Met Asn Leu Leu Leu Val Val Leu Trp Ala Phe Ala Leu Pro Tyr Pro 
        835                 840                 845             


Arg Phe Arg Pro Met Ala Ser Cys Leu Ser Thr Val Trp Thr Cys Val 
    850                 855                 860                 


Ile Ile Val Cys Lys Met Leu Tyr Gln Leu Lys Val Val Asn Pro Gln 
865                 870                 875                 880 


Glu Tyr Ser Ser Asn Cys Thr Glu Pro Phe Pro Asn Ser Thr Asn Leu 
                885                 890                 895     


Leu Pro Thr Glu Ile Ser Gln Ser Leu Leu Tyr Arg Gly Pro Val Asp 
            900                 905                 910         


Pro Ala Asn Trp Phe Gly Val Arg Lys Gly Phe Pro Asn Leu Gly Tyr 
        915                 920                 925             


Ile Gln Asn His Leu Gln Val Leu Leu Leu Leu Val Phe Glu Ala Ile 
    930                 935                 940                 


Val Tyr Arg Arg Gln Glu His Tyr Arg Arg Gln His Gln Leu Ala Pro 
945                 950                 955                 960 


Leu Pro Ala Gln Ala Val Phe Ala Ser Gly Thr Arg Gln Gln Leu Asp 
                965                 970                 975     


Gln Asp Leu Leu Gly Cys Leu Lys Tyr Phe Ile Asn Phe Phe Phe Tyr 
            980                 985                 990         


Lys Phe Gly Leu Glu Ile Cys Phe  Leu Met Ala Val Asn  Val Ile Gly 
        995                 1000                 1005             


Gln Arg  Met Asn Phe Leu Val  Thr Leu His Gly Cys  Trp Leu Val 
    1010                 1015                 1020             


Ala Ile  Leu Thr Arg Arg His  Arg Gln Ala Ile Ala  Arg Leu Trp 
    1025                 1030                 1035             


Pro Asn  Tyr Cys Leu Phe Leu  Ala Leu Phe Leu Leu  Tyr Gln Tyr 
    1040                 1045                 1050             


Leu Leu  Cys Leu Gly Met Pro  Pro Ala Leu Cys Ile  Asp Tyr Pro 
    1055                 1060                 1065             


Trp Arg  Trp Ser Arg Ala Val  Pro Met Asn Ser Ala  Leu Ile Lys 
    1070                 1075                 1080             


Trp Leu  Tyr Leu Pro Asp Phe  Phe Arg Ala Pro Asn  Ser Thr Asn 
    1085                 1090                 1095             


Leu Ile  Ser Asp Phe Leu Leu  Leu Leu Cys Ala Ser  Gln Gln Trp 
    1100                 1105                 1110             


Gln Val  Phe Ser Ala Glu Arg  Thr Glu Glu Trp Gln  Arg Met Ala 
    1115                 1120                 1125             


Gly Val  Asn Thr Asp Arg Leu  Glu Pro Leu Arg Gly  Glu Pro Asn 
    1130                 1135                 1140             


Pro Val  Pro Asn Phe Ile His  Cys Arg Ser Tyr Leu  Asp Met Leu 
    1145                 1150                 1155             


Lys Val  Ala Val Phe Arg Tyr  Leu Phe Trp Leu Val  Leu Val Val 
    1160                 1165                 1170             


Val Phe  Val Thr Gly Ala Thr  Arg Ile Ser Ile Phe  Gly Leu Gly 
    1175                 1180                 1185             


Tyr Leu  Leu Ala Cys Phe Tyr  Leu Leu Leu Phe Gly  Thr Ala Leu 
    1190                 1195                 1200             


Leu Gln  Arg Asp Thr Arg Ala  Arg Leu Val Leu Trp  Asp Cys Leu 
    1205                 1210                 1215             


Ile Leu  Tyr Asn Val Thr Val  Ile Ile Ser Lys Asn  Met Leu Ser 
    1220                 1225                 1230             


Leu Leu  Ala Cys Val Phe Val  Glu Gln Met Gln Thr  Gly Phe Cys 
    1235                 1240                 1245             


Trp Val  Ile Gln Leu Phe Ser  Leu Val Cys Thr Val  Lys Gly Tyr 
    1250                 1255                 1260             


Tyr Asp  Pro Lys Glu Met Met  Asp Arg Asp Gln Asp  Cys Leu Leu 
    1265                 1270                 1275             


Pro Val  Glu Glu Ala Gly Ile  Ile Trp Asp Ser Val  Cys Phe Phe 
    1280                 1285                 1290             


Phe Leu  Leu Leu Gln Arg Arg  Val Phe Leu Ser His  Tyr Tyr Leu 
    1295                 1300                 1305             


His Val  Arg Ala Asp Leu Gln  Ala Thr Ala Leu Leu  Ala Ser Arg 
    1310                 1315                 1320             


Gly Phe  Ala Leu Tyr Asn Ala  Ala Asn Leu Lys Ser  Ile Asp Phe 
    1325                 1330                 1335             


His Arg  Arg Ile Glu Glu Lys  Ser Leu Ala Gln Leu  Lys Arg Gln 
    1340                 1345                 1350             


Met Glu  Arg Ile Arg Ala Lys  Gln Glu Lys His Arg  Gln Gly Arg 
    1355                 1360                 1365             


Val Asp  Arg Ser Arg Pro Gln  Asp Thr Leu Gly Pro  Lys Asp Pro 
    1370                 1375                 1380             


Gly Leu  Glu Pro Gly Pro Asp  Ser Pro Gly Gly Ser  Ser Pro Pro 
    1385                 1390                 1395             


Arg Arg  Gln Trp Trp Arg Pro  Trp Leu Asp His Ala  Thr Val Ile 
    1400                 1405                 1410             


His Ser  Gly Asp Tyr Phe Leu  Phe Glu Ser Asp Ser  Glu Glu Glu 
    1415                 1420                 1425             


Glu Glu  Ala Val Pro Glu Asp  Pro Arg Pro Ser Ala  Gln Ser Ala 
    1430                 1435                 1440             


Phe Gln  Leu Ala Tyr Gln Ala  Trp Val Thr Asn Ala  Gln Ala Val 
    1445                 1450                 1455             


Leu Arg  Arg Arg Gln Gln Glu  Gln Glu Gln Ala Arg  Gln Glu Gln 
    1460                 1465                 1470             


Ala Gly  Gln Leu Pro Thr Gly  Gly Gly Pro Ser Gln  Glu Val Glu 
    1475                 1480                 1485             


Pro Ala  Glu Gly Pro Glu Glu  Ala Ala Ala Gly Arg  Ser His Val 
    1490                 1495                 1500             


Val Gln  Arg Val Leu Ser Thr  Ala Gln Phe Leu Trp  Met Leu Gly 
    1505                 1510                 1515             


Gln Ala  Leu Val Asp Glu Leu  Thr Arg Trp Leu Gln  Glu Phe Thr 
    1520                 1525                 1530             


Arg His  His Gly Thr Met Ser  Asp Val Leu Arg Ala  Glu Arg Tyr 
    1535                 1540                 1545             


Leu Leu  Thr Gln Glu Leu Leu  Gln Gly Gly Glu Val  His Arg Gly 
    1550                 1555                 1560             


Val Leu  Asp Gln Leu Tyr Thr  Ser Gln Ala Glu Ala  Thr Leu Pro 
    1565                 1570                 1575             


Gly Pro  Thr Glu Ala Pro Asn  Ala Pro Ser Thr Val  Ser Ser Gly 
    1580                 1585                 1590             


Leu Gly  Ala Glu Glu Pro Leu  Ser Ser Met Thr Asp  Asp Met Gly 
    1595                 1600                 1605             


Ser Pro  Leu Ser Thr Gly Tyr  His Thr Arg Ser Gly  Ser Glu Glu 
    1610                 1615                 1620             


Ala Val  Thr Asp Pro Gly Glu  Arg Glu Ala Gly Ala  Ser Leu Tyr 
    1625                 1630                 1635             


Gln Gly  Leu Met Arg Thr Ala  Ser Glu Leu Leu Leu  Asp Arg Arg 
    1640                 1645                 1650             


Leu Arg  Ile Pro Glu Leu Glu  Glu Ala Glu Leu Phe  Ala Glu Gly 
    1655                 1660                 1665             


Gln Gly  Arg Ala Leu Arg Leu  Leu Arg Ala Val Tyr  Gln Cys Val 
    1670                 1675                 1680             


Ala Ala  His Ser Glu Leu Leu  Cys Tyr Phe Ile Ile  Ile Leu Asn 
    1685                 1690                 1695             


His Met  Val Thr Ala Ser Ala  Gly Ser Leu Val Leu  Pro Val Leu 
    1700                 1705                 1710             


Val Phe  Leu Trp Ala Met Leu  Ser Ile Pro Arg Pro  Ser Lys Arg 
    1715                 1720                 1725             


Phe Trp  Met Thr Ala Ile Val  Phe Thr Glu Ile Ala  Val Val Val 
    1730                 1735                 1740             


Lys Tyr  Leu Phe Gln Phe Gly  Phe Phe Pro Trp Asn  Ser His Val 
    1745                 1750                 1755             


Val Leu  Arg Arg Tyr Glu Asn  Lys Pro Tyr Phe Pro  Pro Arg Ile 
    1760                 1765                 1770             


Leu Gly  Leu Glu Lys Thr Asp  Gly Tyr Ile Lys Tyr  Asp Leu Val 
    1775                 1780                 1785             


Gln Leu  Met Ala Leu Phe Phe  His Arg Ser Gln Leu  Leu Cys Tyr 
    1790                 1795                 1800             


Gly Leu  Trp Asp His Glu Glu  Asp Ser Pro Ser Lys  Glu His Asp 
    1805                 1810                 1815             


Lys Ser  Gly Glu Glu Glu Gln  Gly Ala Glu Glu Gly  Pro Gly Val 
    1820                 1825                 1830             


Pro Ala  Ala Thr Thr Glu Asp  His Ile Gln Val Glu  Ala Arg Val 
    1835                 1840                 1845             


Gly Pro  Thr Asp Gly Thr Pro  Glu Pro Gln Val Glu  Leu Arg Pro 
    1850                 1855                 1860             


Arg Asp  Thr Arg Arg Ile Ser  Leu Arg Phe Arg Arg  Arg Lys Lys 
    1865                 1870                 1875             


Glu Gly  Pro Ala Arg Lys Gly  Ala Ala Ala Ile Glu  Ala Glu Asp 
    1880                 1885                 1890             


Arg Glu  Glu Glu Glu Gly Glu  Glu Glu Lys Glu Ala  Pro Thr Gly 
    1895                 1900                 1905             


Arg Glu  Lys Arg Pro Ser Arg  Ser Gly Gly Arg Val  Arg Ala Ala 
    1910                 1915                 1920             


Gly Arg  Arg Leu Gln Gly Phe  Cys Leu Ser Leu Ala  Gln Gly Thr 
    1925                 1930                 1935             


Tyr Arg  Pro Leu Arg Arg Phe  Phe His Asp Ile Leu  His Thr Lys 
    1940                 1945                 1950             


Tyr Arg  Ala Ala Thr Asp Val  Tyr Ala Leu Met Phe  Leu Ala Asp 
    1955                 1960                 1965             


Val Val  Asp Phe Ile Ile Ile  Ile Phe Gly Phe Trp  Ala Phe Gly 
    1970                 1975                 1980             


Lys His  Ser Ala Ala Thr Asp  Ile Thr Ser Ser Leu  Ser Asp Asp 
    1985                 1990                 1995             


Gln Val  Pro Glu Ala Phe Leu  Val Met Leu Leu Ile  Gln Phe Ser 
    2000                 2005                 2010             


Thr Met  Val Val Asp Arg Ala  Leu Tyr Leu Arg Lys  Thr Val Leu 
    2015                 2020                 2025             


Gly Lys  Leu Ala Phe Gln Val  Ala Leu Val Leu Ala  Ile His Leu 
    2030                 2035                 2040             


Trp Met  Phe Phe Ile Leu Pro  Ala Val Thr Glu Arg  Met Phe Asn 
    2045                 2050                 2055             


Gln Asn  Val Val Ala Gln Leu  Trp Tyr Phe Val Lys  Cys Ile Tyr 
    2060                 2065                 2070             


Phe Ala  Leu Ser Ala Tyr Gln  Ile Arg Cys Gly Tyr  Pro Thr Arg 
    2075                 2080                 2085             


Ile Leu  Gly Asn Phe Leu Thr  Lys Lys Tyr Asn His  Leu Asn Leu 
    2090                 2095                 2100             


Phe Leu  Phe Gln Gly Phe Arg  Leu Val Pro Phe Leu  Val Glu Leu 
    2105                 2110                 2115             


Arg Ala  Val Met Asp Trp Val  Trp Thr Asp Thr Thr  Leu Ser Leu 
    2120                 2125                 2130             


Ser Ser  Trp Met Cys Val Glu  Asp Ile Tyr Ala Asn  Ile Phe Ile 
    2135                 2140                 2145             


Ile Lys  Cys Ser Arg Glu Thr  Glu Lys Lys Tyr Pro  Gln Pro Lys 
    2150                 2155                 2160             


Gly Gln  Lys Lys Lys Lys Ile  Val Lys Tyr Gly Met  Gly Gly Leu 
    2165                 2170                 2175             


Ile Ile  Leu Phe Leu Ile Ala  Ile Ile Trp Phe Pro  Leu Leu Phe 
    2180                 2185                 2190             


Met Ser  Leu Val Arg Ser Val  Val Gly Val Val Asn  Gln Pro Ile 
    2195                 2200                 2205             


Asp Val  Thr Val Thr Leu Lys  Leu Gly Gly Tyr Glu  Pro Leu Phe 
    2210                 2215                 2220             


Thr Met  Ser Ala Gln Gln Pro  Ser Ile Ile Pro Phe  Thr Ala Gln 
    2225                 2230                 2235             


Ala Tyr  Glu Glu Leu Ser Arg  Gln Phe Asp Pro Gln  Pro Leu Ala 
    2240                 2245                 2250             


Met Gln  Phe Ile Ser Gln Tyr  Ser Pro Glu Asp Ile  Val Thr Ala 
    2255                 2260                 2265             


Gln Ile  Glu Gly Ser Ser Gly  Ala Leu Trp Arg Ile  Ser Pro Pro 
    2270                 2275                 2280             


Ser Arg  Ala Gln Met Lys Arg  Glu Leu Tyr Asn Gly  Thr Ala Asp 
    2285                 2290                 2295             


Ile Thr  Leu Arg Phe Thr Trp  Asn Phe Gln Arg Asp  Leu Ala Lys 
    2300                 2305                 2310             


Gly Gly  Thr Val Glu Tyr Ala  Asn Glu Lys His Met  Leu Ala Leu 
    2315                 2320                 2325             


Ala Pro  Asn Ser Thr Ala Arg  Arg Gln Leu Ala Ser  Leu Leu Glu 
    2330                 2335                 2340             


Gly Thr  Ser Asp Gln Ser Val  Val Ile Pro Asn Leu  Phe Pro Lys 
    2345                 2350                 2355             


Tyr Ile  Arg Ala Pro Asn Gly  Pro Glu Ala Asn Pro  Val Lys Gln 
    2360                 2365                 2370             


Leu Gln  Pro Asn Glu Glu Ala  Asp Tyr Leu Gly Val  Arg Ile Gln 
    2375                 2380                 2385             


Leu Arg  Arg Glu Gln Gly Ala  Gly Ala Thr Gly Phe  Leu Glu Trp 
    2390                 2395                 2400             


Trp Val  Ile Glu Leu Gln Glu  Cys Arg Thr Asp Cys  Asn Leu Leu 
    2405                 2410                 2415             


Pro Met  Val Ile Phe Ser Asp  Lys Val Ser Pro Pro  Ser Leu Gly 
    2420                 2425                 2430             


Phe Leu  Ala Gly Tyr Gly Ile  Met Gly Leu Tyr Val  Ser Ile Val 
    2435                 2440                 2445             


Leu Val  Ile Gly Lys Phe Val  Arg Gly Phe Phe Ser  Glu Ile Ser 
    2450                 2455                 2460             


His Ser  Ile Met Phe Glu Glu  Leu Pro Cys Val Asp  Arg Ile Leu 
    2465                 2470                 2475             


Lys Leu  Cys Gln Asp Ile Phe  Leu Val Arg Glu Thr  Arg Glu Leu 
    2480                 2485                 2490             


Glu Leu  Glu Glu Glu Leu Tyr  Ala Lys Leu Ile Phe  Leu Tyr Arg 
    2495                 2500                 2505             


Ser Pro  Glu Thr Met Ile Lys  Trp Thr Arg Glu Lys  Glu 
    2510                 2515                 2520     


<210>  1707
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  1707

Met Pro Glu Leu Val Val Thr Ala Leu Leu Ala Pro Ser Arg Leu Ser 
1               5                   10                  15      


Leu Lys Leu Leu Arg Ala Phe Met Trp Ser Leu Val Phe Ser Val Ala 
            20                  25                  30          


Leu Val Ala Ala Ala Val Tyr Gly Cys Ile Ala Leu Thr His Val Leu 
        35                  40                  45              


Cys Arg Pro Arg Arg Gly Cys Cys Gly Arg Arg Arg Ser Ala Ser Pro 
    50                  55                  60                  


Ala Cys Leu Ser Asp Pro Ser Leu Gly Glu His Gly Phe Leu Asn Leu 
65                  70                  75                  80  


Lys Ser Ser Gly Leu Arg Leu His Tyr Val Ser Ala Gly Arg Gly Asn 
                85                  90                  95      


Gly Pro Leu Met Leu Phe Leu His Gly Phe Pro Glu Asn Trp Phe Ser 
            100                 105                 110         


Trp Arg Tyr Gln Leu Arg Glu Phe Gln Ser Arg Phe His Val Val Ala 
        115                 120                 125             


Val Asp Leu Arg Gly Tyr Gly Pro Ser Asp Ala Pro Arg Asp Val Asp 
    130                 135                 140                 


Cys Tyr Thr Ile Asp Leu Leu Leu Val Asp Ile Lys Asp Val Ile Leu 
145                 150                 155                 160 


Gly Leu Gly Tyr Ser Lys Cys Ile Leu Val Ala His Asp Trp Gly Ala 
                165                 170                 175     


Leu Leu Ala Trp His Phe Ser Ile Tyr Tyr Pro Ser Leu Val Glu Arg 
            180                 185                 190         


Met Val Val Val Ser Gly Ala Pro Met Ser Val Tyr Gln Asp Tyr Ser 
        195                 200                 205             


Leu His His Ile Ser Gln Phe Phe Arg Ser His Tyr Met Phe Leu Phe 
    210                 215                 220                 


Gln Leu Pro Trp Leu Pro Glu Lys Leu Leu Ser Met Ser Asp Phe Gln 
225                 230                 235                 240 


Ile Leu Lys Thr Thr Leu Thr His Arg Lys Thr Gly Ile Pro Cys Leu 
                245                 250                 255     


Thr Pro Ser Glu Leu Glu Ala Phe Leu Tyr Asn Phe Ser Gln Pro Gly 
            260                 265                 270         


Gly Leu Thr Gly Pro Leu Asn Tyr Tyr Arg Asn Leu Phe Arg Asn Phe 
        275                 280                 285             


Pro Leu Glu Pro Gln Glu Leu Thr Thr Pro Thr Leu Leu Leu Trp Gly 
    290                 295                 300                 


Glu Lys Asp Thr Tyr Leu Glu Leu Gly Leu Val Glu Ala Ile Gly Ser 
305                 310                 315                 320 


Arg Phe Val Pro Gly Arg Leu Glu Ala His Ile Leu Pro Gly Ile Gly 
                325                 330                 335     


His Trp Ile Pro Gln Ser Asn Pro Gln Glu Met His Gln Tyr Met Trp 
            340                 345                 350         


Ala Phe Leu Gln Asp Leu Leu Asp 
        355                 360 


<210>  1708
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  1708

Met Pro Gly Met Val Leu Phe Gly Arg Arg Trp Ala Ile Ala Ser Asp 
1               5                   10                  15      


Asp Leu Val Phe Pro Gly Phe Phe Glu Leu Val Val Arg Val Leu Trp 
            20                  25                  30          


Trp Ile Gly Ile Leu Thr Leu Tyr Leu Met His Arg Gly Lys Leu Asp 
        35                  40                  45              


Cys Ala Gly Gly Ala Leu Leu Ser Ser Tyr Leu Ile Val Leu Met Ile 
    50                  55                  60                  


Leu Leu Ala Val Val Ile Cys Thr Val Ser Ala Ile Met Cys Val Ser 
65                  70                  75                  80  


Met Arg Gly Thr Ile Cys Asn Pro Gly Pro Arg Lys Ser Met Ser Lys 
                85                  90                  95      


Leu Leu Tyr Ile Arg Leu Ala Leu Phe Phe Pro Glu Met Val Trp Ala 
            100                 105                 110         


Ser Leu Gly Ala Ala Trp Val Ala Asp Gly Val Gln Cys Asp Arg Thr 
        115                 120                 125             


Val Val Asn Gly Ile Ile Ala Thr Val Val Val Arg Thr Gln Ile Trp 
    130                 135                 140                 


Cys Pro Ala Thr Leu Arg Arg Ala Ser Pro Cys Phe Ile Ser Asn Arg 
145                 150                 155                 160 


Thr Ile Ser Gly Thr Thr Lys Ser Leu Pro Arg Trp Ser Ala Met Pro 
                165                 170                 175     


Gln Gly Ala Pro Ser Cys Arg Ser Arg Thr Thr Asp Tyr Asp Leu Val 
            180                 185                 190         


Gly Gly Asp Gln Leu Asn Cys His Phe Gly Ser Ile Leu His Thr Thr 
        195                 200                 205             


Gly Leu Gln Tyr Arg Asp Phe Ile His Val Ser Phe His Asp Lys Val 
    210                 215                 220                 


Tyr Glu Leu Pro Phe Leu Val Ala Leu Asp His Arg Lys Glu Ser Val 
225                 230                 235                 240 


Val Val Ala Val Arg Gly Thr Met Ser Leu Gln Asp Val Leu Thr Asp 
                245                 250                 255     


Leu Ser Ala Glu Ser Glu Val Leu Asp Val Glu Cys Glu Val Gln Asp 
            260                 265                 270         


Arg Leu Ala His Lys Gly Ile Ser Gln Ala Ala Arg Tyr Val Tyr Gln 
        275                 280                 285             


Arg Leu Ile Asn Asp Gly Ile Leu Ser Gln Ala Phe Ser Ile Ala Pro 
    290                 295                 300                 


Glu Tyr Arg Leu Val Ile Val Gly His Ser Leu Gly Gly Gly Ala Ala 
305                 310                 315                 320 


Ala Leu Leu Ala Thr Met Leu Arg Ala Ala Tyr Pro Gln Val Arg Cys 
                325                 330                 335     


Tyr Ala Phe Ser Pro Pro Arg Gly Leu Trp Ser Lys Ala Leu Gln Glu 
            340                 345                 350         


Tyr Ser Gln Ser Phe Ile Val Ser Leu Val Leu Gly Lys Asp Val Ile 
        355                 360                 365             


Pro Arg Leu Ser Val Thr Asn Leu Glu Asp Leu Lys Arg Arg Ile Leu 
    370                 375                 380                 


Arg Val Val Ala His Cys Asn Lys Pro Lys Tyr Lys Ile Leu Leu His 
385                 390                 395                 400 


Gly Leu Trp Tyr Glu Leu Phe Gly Gly Asn Pro Asn Asn Leu Pro Thr 
                405                 410                 415     


Glu Leu Asp Gly Gly Asp Gln Glu Val Leu Thr Gln Pro Leu Leu Gly 
            420                 425                 430         


Glu Gln Ser Leu Leu Thr Arg Trp Ser Pro Ala Tyr Ser Phe Ser Ser 
        435                 440                 445             


Asp Ser Pro Leu Asp Ser Ser Pro Lys Tyr Pro Pro Leu Tyr Pro Pro 
    450                 455                 460                 


Gly Arg Ile Ile His Leu Gln Glu Glu Gly Ala Ser Gly Arg Phe Gly 
465                 470                 475                 480 


Cys Cys Ser Ala Ala His Tyr Ser Ala Lys Trp Ser His Glu Ala Glu 
                485                 490                 495     


Phe Ser Lys Ile Leu Ile Gly Pro Lys Met Leu Thr Asp His Met Pro 
            500                 505                 510         


Asp Ile Leu Met Arg Ala Leu Asp Ser Val Val Ser Asp Arg Ala Ala 
        515                 520                 525             


Cys Val Ser Cys Pro Ala Gln Gly Val Ser Ser Val Asp Val Ala 
    530                 535                 540             


<210>  1709
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  1709

Met Leu Ala Asn Ser Ser Ser Thr Asn Ser Ser Val Leu Pro Cys Pro 
1               5                   10                  15      


Asp Tyr Arg Pro Thr His Arg Leu His Leu Val Val Tyr Ser Leu Val 
            20                  25                  30          


Leu Ala Ala Gly Leu Pro Leu Asn Ala Leu Ala Leu Trp Val Phe Leu 
        35                  40                  45              


Arg Ala Leu Arg Val His Ser Val Val Ser Val Tyr Met Cys Asn Leu 
    50                  55                  60                  


Ala Ala Ser Asp Leu Leu Phe Thr Leu Ser Leu Pro Val Arg Leu Ser 
65                  70                  75                  80  


Tyr Tyr Ala Leu His His Trp Pro Phe Pro Asp Leu Leu Cys Gln Thr 
                85                  90                  95      


Thr Gly Ala Ile Phe Gln Met Asn Met Tyr Gly Ser Cys Ile Phe Leu 
            100                 105                 110         


Met Leu Ile Asn Val Asp Arg Tyr Ala Ala Ile Val His Pro Leu Arg 
        115                 120                 125             


Leu Arg His Leu Arg Arg Pro Arg Val Ala Arg Leu Leu Cys Leu Gly 
    130                 135                 140                 


Val Trp Ala Leu Ile Leu Val Phe Ala Val Pro Ala Ala Arg Val His 
145                 150                 155                 160 


Arg Pro Ser Arg Cys Arg Tyr Arg Asp Leu Glu Val Arg Leu Cys Phe 
                165                 170                 175     


Glu Ser Phe Ser Asp Glu Leu Trp Lys Gly Arg Leu Leu Pro Leu Val 
            180                 185                 190         


Leu Leu Ala Glu Ala Leu Gly Phe Leu Leu Pro Leu Ala Ala Val Val 
        195                 200                 205             


Tyr Ser Ser Gly Arg Val Phe Trp Thr Leu Ala Arg Pro Asp Ala Thr 
    210                 215                 220                 


Gln Ser Gln Arg Arg Arg Lys Thr Val Arg Leu Leu Leu Ala Asn Leu 
225                 230                 235                 240 


Val Ile Phe Leu Leu Cys Phe Val Pro Tyr Asn Ser Thr Leu Ala Val 
                245                 250                 255     


Tyr Gly Leu Leu Arg Ser Lys Leu Val Ala Ala Ser Val Pro Ala Arg 
            260                 265                 270         


Asp Arg Val Arg Gly Val Leu Met Val Met Val Leu Leu Ala Gly Ala 
        275                 280                 285             


Asn Cys Val Leu Asp Pro Leu Val Tyr Tyr Phe Ser Ala Glu Gly Phe 
    290                 295                 300                 


Arg Asn Thr Leu Arg Gly Leu Gly Thr Pro His Arg Ala Arg Thr Ser 
305                 310                 315                 320 


Ala Thr Asn Gly Thr Arg Ala Ala Leu Ala Gln Ser Glu Arg Ser Ala 
                325                 330                 335     


Val Thr Thr Asp Ala Thr Arg Pro Asp Ala Ala Ser Gln Gly Leu Leu 
            340                 345                 350         


Arg Pro Ser Asp Ser His Ser Leu Ser Ser Phe Thr Gln Cys Pro Gln 
        355                 360                 365             


Asp Ser Ala Leu 
    370         


<210>  1710
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  1710

Met Ser Leu Arg Val His Thr Leu Pro Thr Leu Leu Gly Ala Val Val 
1               5                   10                  15      


Arg Pro Gly Cys Arg Glu Leu Leu Cys Leu Leu Met Ile Thr Val Thr 
            20                  25                  30          


Val Gly Pro Gly Ala Ser Gly Val Cys Pro Thr Ala Cys Ile Cys Ala 
        35                  40                  45              


Thr Asp Ile Val Ser Cys Thr Asn Lys Asn Leu Ser Lys Val Pro Gly 
    50                  55                  60                  


Asn Leu Phe Arg Leu Ile Lys Arg Leu Asp Leu Ser Tyr Asn Arg Ile 
65                  70                  75                  80  


Gly Leu Leu Asp Ser Glu Trp Ile Pro Val Ser Phe Ala Lys Leu Asn 
                85                  90                  95      


Thr Leu Ile Leu Arg His Asn Asn Ile Thr Ser Ile Ser Thr Gly Ser 
            100                 105                 110         


Phe Ser Thr Thr Pro Asn Leu Lys Cys Leu Asp Leu Ser Ser Asn Lys 
        115                 120                 125             


Leu Lys Thr Val Lys Asn Ala Val Phe Gln Glu Leu Lys Val Leu Glu 
    130                 135                 140                 


Val Leu Leu Leu Tyr Asn Asn His Ile Ser Tyr Leu Asp Pro Ser Ala 
145                 150                 155                 160 


Phe Gly Gly Leu Ser Gln Leu Gln Lys Leu Tyr Leu Ser Gly Asn Phe 
                165                 170                 175     


Leu Thr Gln Phe Pro Met Asp Leu Tyr Val Gly Arg Phe Lys Leu Ala 
            180                 185                 190         


Glu Leu Met Phe Leu Asp Val Ser Tyr Asn Arg Ile Pro Ser Met Pro 
        195                 200                 205             


Met His His Ile Asn Leu Val Pro Gly Lys Gln Leu Arg Gly Ile Tyr 
    210                 215                 220                 


Leu His Gly Asn Pro Phe Val Cys Asp Cys Ser Leu Tyr Ser Leu Leu 
225                 230                 235                 240 


Val Phe Trp Tyr Arg Arg His Phe Ser Ser Val Met Asp Phe Lys Asn 
                245                 250                 255     


Asp Tyr Thr Cys Arg Leu Trp Ser Asp Ser Arg His Ser Arg Gln Val 
            260                 265                 270         


Leu Leu Leu Gln Asp Ser Phe Met Asn Cys Ser Asp Ser Ile Ile Asn 
        275                 280                 285             


Gly Ser Phe Arg Ala Leu Gly Phe Ile His Glu Ala Gln Val Gly Glu 
    290                 295                 300                 


Arg Leu Met Val His Cys Asp Ser Lys Thr Gly Asn Ala Asn Thr Asp 
305                 310                 315                 320 


Phe Ile Trp Val Gly Pro Asp Asn Arg Leu Leu Glu Pro Asp Lys Glu 
                325                 330                 335     


Met Glu Asn Phe Tyr Val Phe His Asn Gly Ser Leu Val Ile Glu Ser 
            340                 345                 350         


Pro Arg Phe Glu Asp Ala Gly Val Tyr Ser Cys Ile Ala Met Asn Lys 
        355                 360                 365             


Gln Arg Leu Leu Asn Glu Thr Val Asp Val Thr Ile Asn Val Ser Asn 
    370                 375                 380                 


Phe Thr Val Ser Arg Ser His Ala His Glu Ala Phe Asn Thr Ala Phe 
385                 390                 395                 400 


Thr Thr Leu Ala Ala Cys Val Ala Ser Ile Val Leu Val Leu Leu Tyr 
                405                 410                 415     


Leu Tyr Leu Thr Pro Cys Pro Cys Lys Cys Lys Thr Lys Arg Gln Lys 
            420                 425                 430         


Asn Met Leu His Gln Ser Asn Ala His Ser Ser Ile Leu Ser Pro Gly 
        435                 440                 445             


Pro Ala Ser Asp Ala Ser Ala Asp Glu Arg Lys Ala Gly Ala Gly Lys 
    450                 455                 460                 


Arg Val Val Phe Leu Glu Pro Leu Lys Asp Thr Ala Ala Gly Gln Asn 
465                 470                 475                 480 


Gly Lys Val Arg Leu Phe Pro Ser Glu Ala Val Ile Ala Glu Gly Ile 
                485                 490                 495     


Leu Lys Ser Thr Arg Gly Lys Ser Asp Ser Asp Ser Val Asn Ser Val 
            500                 505                 510         


Phe Ser Asp Thr Pro Phe Val Ala Ser Thr 
        515                 520         


<210>  1711
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  1711

Met Ser Gly Asn Trp Val His Pro Gly Gln Ile Leu Ile Trp Ala Ile 
1               5                   10                  15      


Trp Val Leu Ala Ala Pro Thr Lys Gly Pro Ser Ala Glu Gly Pro Gln 
            20                  25                  30          


Arg Asn Thr Arg Leu Gly Trp Ile Gln Gly Lys Gln Val Thr Val Leu 
        35                  40                  45              


Gly Ser Pro Val Pro Val Asn Val Phe Leu Gly Val Pro Phe Ala Ala 
    50                  55                  60                  


Pro Pro Leu Gly Ser Leu Arg Phe Thr Asn Pro Gln Pro Ala Ser Pro 
65                  70                  75                  80  


Trp Asp Asn Leu Arg Glu Ala Thr Ser Tyr Pro Asn Leu Cys Leu Gln 
                85                  90                  95      


Asn Ser Glu Trp Leu Leu Leu Asp Gln His Met Leu Lys Val His Tyr 
            100                 105                 110         


Pro Lys Phe Gly Val Ser Glu Asp Cys Leu Tyr Leu Asn Ile Tyr Ala 
        115                 120                 125             


Pro Ala His Ala Asp Thr Gly Ser Lys Leu Pro Val Leu Val Trp Phe 
    130                 135                 140                 


Pro Gly Gly Ala Phe Lys Thr Gly Ser Ala Ser Ile Phe Asp Gly Ser 
145                 150                 155                 160 


Ala Leu Ala Ala Tyr Glu Asp Val Leu Val Val Val Val Gln Tyr Arg 
                165                 170                 175     


Leu Gly Ile Phe Gly Phe Phe Thr Thr Trp Asp Gln His Ala Pro Gly 
            180                 185                 190         


Asn Trp Ala Phe Lys Asp Gln Val Ala Ala Leu Ser Trp Val Gln Lys 
        195                 200                 205             


Asn Ile Glu Phe Phe Gly Gly Asp Pro Ser Ser Val Thr Ile Phe Gly 
    210                 215                 220                 


Glu Ser Ala Gly Ala Ile Ser Val Ser Ser Leu Ile Leu Ser Pro Met 
225                 230                 235                 240 


Ala Lys Gly Leu Phe His Lys Ala Ile Met Glu Ser Gly Val Ala Ile 
                245                 250                 255     


Ile Pro Tyr Leu Glu Ala His Asp Tyr Glu Lys Ser Glu Asp Leu Gln 
            260                 265                 270         


Val Val Ala His Phe Cys Gly Asn Asn Ala Ser Asp Ser Glu Ala Leu 
        275                 280                 285             


Leu Arg Cys Leu Arg Thr Lys Pro Ser Lys Glu Leu Leu Thr Leu Ser 
    290                 295                 300                 


Gln Lys Thr Lys Ser Phe Thr Arg Val Val Asp Gly Ala Phe Phe Pro 
305                 310                 315                 320 


Asn Glu Pro Leu Asp Leu Leu Ser Gln Lys Ala Phe Lys Ala Ile Pro 
                325                 330                 335     


Ser Ile Ile Gly Val Asn Asn His Glu Cys Gly Phe Leu Leu Pro Met 
            340                 345                 350         


Lys Glu Ala Pro Glu Ile Leu Ser Gly Ser Asn Lys Ser Leu Ala Leu 
        355                 360                 365             


His Leu Ile Gln Asn Ile Leu His Ile Pro Pro Gln Tyr Leu His Leu 
    370                 375                 380                 


Val Ala Asn Glu Tyr Phe His Asp Lys His Ser Leu Thr Glu Ile Arg 
385                 390                 395                 400 


Asp Ser Leu Leu Asp Leu Leu Gly Asp Val Phe Phe Val Val Pro Ala 
                405                 410                 415     


Leu Ile Thr Ala Arg Tyr His Arg Asp Ala Gly Ala Pro Val Tyr Phe 
            420                 425                 430         


Tyr Glu Phe Arg His Arg Pro Gln Cys Phe Glu Asp Thr Lys Pro Ala 
        435                 440                 445             


Phe Val Lys Ala Asp His Ala Asp Glu Val Arg Phe Val Phe Gly Gly 
    450                 455                 460                 


Ala Phe Leu Lys Gly Asp Ile Val Met Phe Glu Gly Ala Thr Glu Glu 
465                 470                 475                 480 


Glu Lys Leu Leu Ser Arg Lys Met Met Lys Tyr Trp Ala Thr Phe Ala 
                485                 490                 495     


Arg Thr Gly Asn Pro Asn Gly Asn Asp Leu Ser Leu Trp Pro Ala Tyr 
            500                 505                 510         


Asn Leu Thr Glu Gln Tyr Leu Gln Leu Asp Leu Asn Met Ser Leu Gly 
        515                 520                 525             


Gln Arg Leu Lys Glu Pro Arg Val Asp Phe Trp Thr Ser Thr Ile Pro 
    530                 535                 540                 


Leu Ile Leu Ser Ala Ser Asp Met Leu His Ser Pro Leu Ser Ser Leu 
545                 550                 555                 560 


Thr Phe Leu Ser Leu Leu Gln Pro Phe Phe Phe Phe Cys Ala Pro 
                565                 570                 575 


<210>  1712
<211>  681
<212>  PRT
<213>  Homo sapiens

<400>  1712

Met Asp Ile Lys His His Gln Asn Gly Thr Arg Gly Gln Arg Arg Lys 
1               5                   10                  15      


Gln Pro His Thr Thr Val Gln Arg Leu Leu Thr Trp Gly Leu Pro Val 
            20                  25                  30          


Ser Cys Ser Trp Phe Leu Trp Arg Gln Pro Gly Glu Phe Pro Val Thr 
        35                  40                  45              


Ala Leu Leu Leu Gly Ala Gly Ala Gly Gly Leu Leu Ala Ile Gly Leu 
    50                  55                  60                  


Gly Ala Met Gly Trp Gly Thr Ser Pro His Ile Arg Cys Ala Ser Leu 
65                  70                  75                  80  


Leu Leu Val Pro Lys Met Leu Gly Lys Glu Gly Arg Leu Phe Val Leu 
                85                  90                  95      


Gly Tyr Ala Leu Ala Ala Ile Tyr Val Gly Pro Val Ala Asn Leu Arg 
            100                 105                 110         


His Asn Leu Asn Asn Val Ile Ala Ser Leu Gly Cys Thr Val Glu Leu 
        115                 120                 125             


Gln Ile Asn Asn Thr Arg Ala Ala Trp Arg Ile Ser Thr Ala Pro Leu 
    130                 135                 140                 


Arg Ala Met Phe Lys Asp Leu Leu Ser Ser Lys Glu Leu Leu Arg Ala 
145                 150                 155                 160 


Glu Thr Arg Asn Ile Ser Ala Thr Phe Glu Asp Leu Asp Ala Gln Val 
                165                 170                 175     


Asn Ser Glu Thr Gly Tyr Thr Pro Glu Asp Thr Met Asp Ser Gly Glu 
            180                 185                 190         


Thr Ala Gln Gly Arg Glu Ala Arg Gln Ala Pro Ala Ser Arg Leu His 
        195                 200                 205             


Leu Ser Thr Gln Lys Met Tyr Glu Leu Lys Thr Lys Leu Arg Cys Ser 
    210                 215                 220                 


Tyr Val Val Asn Gln Ala Ile Leu Ser Cys Arg Arg Trp Phe Asp Arg 
225                 230                 235                 240 


Lys His Glu Gln Cys Met Lys His Ile Trp Val Pro Leu Leu Thr His 
                245                 250                 255     


Leu Leu Cys Leu Pro Met Lys Phe Lys Phe Phe Cys Gly Ile Ala Lys 
            260                 265                 270         


Val Met Glu Val Trp Cys Arg Asn Arg Ile Pro Val Glu Gly Asn Phe 
        275                 280                 285             


Gly Gln Thr Tyr Asp Ser Leu Asn Gln Ser Ile Arg Gly Leu Asp Gly 
    290                 295                 300                 


Glu Phe Ser Ala Asn Ile Asp Phe Lys Glu Glu Lys Gln Ala Gly Val 
305                 310                 315                 320 


Leu Gly Leu Asn Thr Ser Trp Glu Arg Val Ser Thr Glu Val Arg Asp 
                325                 330                 335     


Tyr Val Tyr Arg Gln Glu Ala Arg Leu Glu Trp Ala Leu Gly Leu Leu 
            340                 345                 350         


His Val Leu Leu Ser Cys Thr Phe Leu Leu Val Leu His Ala Ser Phe 
        355                 360                 365             


Ser Tyr Met Asp Ser Tyr Asn His Asp Ile Arg Phe Asp Asn Ile Tyr 
    370                 375                 380                 


Ile Ser Thr Tyr Phe Cys Gln Ile Asp Asp Arg Arg Lys Lys Leu Gly 
385                 390                 395                 400 


Lys Arg Thr Leu Leu Pro Leu Arg Lys Ala Glu Glu Lys Thr Val Ile 
                405                 410                 415     


Phe Pro Cys Lys Pro Thr Ile Gln Ala Ser Glu Met Ser Asn Val Val 
            420                 425                 430         


Arg Glu Leu Leu Glu Thr Leu Pro Ile Leu Leu Leu Leu Val Val Leu 
        435                 440                 445             


Cys Gly Leu Asp Trp Ala Leu Tyr Ser Ile Phe Asp Thr Ile Arg His 
    450                 455                 460                 


His Ser Phe Leu Gln Tyr Ser Phe Arg Ser Ser His Lys Leu Glu Val 
465                 470                 475                 480 


Lys Val Gly Gly Asp Ser Met Leu Ala Arg Leu Leu Arg Lys Thr Ile 
                485                 490                 495     


Gly Ala Leu Asn Thr Ser Ser Glu Thr Val Met Glu Ser Asn Asn Met 
            500                 505                 510         


Pro Cys Leu Pro Gln Pro Val Gly Leu Asp Ala Arg Ala Tyr Trp Arg 
        515                 520                 525             


Ala Ala Val Pro Ile Gly Leu Leu Val Cys Leu Cys Leu Leu Gln Ala 
    530                 535                 540                 


Phe Gly Tyr Arg Leu Arg Arg Val Ile Ala Ala Phe Tyr Phe Pro Lys 
545                 550                 555                 560 


Arg Glu Lys Lys Arg Ile Leu Phe Leu Tyr Asn Asp Leu Leu Lys Lys 
                565                 570                 575     


Arg Ala Ala Phe Thr Lys Leu Arg Arg Ala Ala Ile Leu Arg Arg Glu 
            580                 585                 590         


Arg Gln Gln Lys Ala Pro Arg His Pro Leu Ala Asp Ile Leu His Arg 
        595                 600                 605             


Gly Cys Pro Leu Leu Arg Arg Trp Leu Cys Arg Arg Cys Val Val Cys 
    610                 615                 620                 


Gln Ala Pro Glu Thr Pro Glu Ser Tyr Val Cys Arg Thr Leu Asp Cys 
625                 630                 635                 640 


Glu Ala Val Tyr Cys Trp Ser Cys Trp Asp Asp Met Arg Gln Arg Cys 
                645                 650                 655     


Pro Val Cys Thr Pro Arg Glu Glu Leu Ser Ser Ser Ala Phe Ser Asp 
            660                 665                 670         


Ser Asn Asp Asp Thr Ala Tyr Ala Gly 
        675                 680     


<210>  1713
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  1713

Met Met Arg Thr Gln Cys Leu Leu Gly Leu Arg Thr Phe Val Ala Phe 
1               5                   10                  15      


Ala Ala Lys Leu Trp Ser Phe Phe Ile Tyr Leu Leu Arg Arg Gln Ile 
            20                  25                  30          


Arg Thr Val Ile Gln Tyr Gln Thr Val Arg Tyr Asp Ile Leu Pro Leu 
        35                  40                  45              


Ser Pro Val Ser Arg Asn Arg Leu Ala Gln Val Lys Arg Lys Ile Leu 
    50                  55                  60                  


Val Leu Asp Leu Asp Glu Thr Leu Ile His Ser His His Asp Gly Val 
65                  70                  75                  80  


Leu Arg Pro Thr Val Arg Pro Gly Thr Pro Pro Asp Phe Ile Leu Lys 
                85                  90                  95      


Val Val Ile Asp Lys His Pro Val Arg Phe Phe Val His Lys Arg Pro 
            100                 105                 110         


His Val Asp Phe Phe Leu Glu Val Val Ser Gln Trp Tyr Glu Leu Val 
        115                 120                 125             


Val Phe Thr Ala Ser Met Glu Ile Tyr Gly Ser Ala Val Ala Asp Lys 
    130                 135                 140                 


Leu Asp Asn Ser Arg Ser Ile Leu Lys Arg Arg Tyr Tyr Arg Gln His 
145                 150                 155                 160 


Cys Thr Leu Glu Leu Gly Ser Tyr Ile Lys Asp Leu Ser Val Val His 
                165                 170                 175     


Ser Asp Leu Ser Ser Ile Val Ile Leu Asp Asn Ser Pro Gly Ala Tyr 
            180                 185                 190         


Arg Ser His Pro Asp Asn Ala Ile Pro Ile Lys Ser Trp Phe Ser Asp 
        195                 200                 205             


Pro Ser Asp Thr Ala Leu Leu Asn Leu Leu Pro Met Leu Asp Ala Leu 
    210                 215                 220                 


Arg Phe Thr Ala Asp Val Arg Ser Val Leu Ser Arg Asn Leu His Gln 
225                 230                 235                 240 


His Arg Leu Trp 
                


<210>  1714
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  1714

Met Ala Asp Gln Asp Pro Ala Gly Ile Ser Pro Leu Gln Gln Met Val 
1               5                   10                  15      


Ala Ser Gly Thr Gly Ala Val Val Thr Ser Leu Phe Met Thr Pro Leu 
            20                  25                  30          


Asp Val Val Lys Val Arg Leu Gln Ser Gln Arg Pro Ser Met Ala Ser 
        35                  40                  45              


Glu Leu Met Pro Ser Ser Arg Leu Trp Ser Leu Ser Tyr Thr Lys Leu 
    50                  55                  60                  


Pro Ser Ser Leu Gln Ser Thr Gly Lys Cys Leu Leu Tyr Cys Asn Gly 
65                  70                  75                  80  


Val Leu Glu Pro Leu Tyr Leu Cys Pro Asn Gly Ala Arg Cys Ala Thr 
                85                  90                  95      


Trp Phe Gln Asp Pro Thr Arg Phe Thr Gly Thr Met Asp Ala Phe Val 
            100                 105                 110         


Lys Ile Val Arg His Glu Gly Thr Arg Thr Leu Trp Ser Gly Leu Pro 
        115                 120                 125             


Ala Thr Leu Val Met Thr Val Pro Ala Thr Ala Ile Tyr Phe Thr Ala 
    130                 135                 140                 


Tyr Asp Gln Leu Lys Ala Phe Leu Cys Gly Arg Ala Leu Thr Ser Asp 
145                 150                 155                 160 


Leu Tyr Ala Pro Met Val Ala Gly Ala Leu Ala Arg Leu Gly Thr Val 
                165                 170                 175     


Thr Val Ile Ser Pro Leu Glu Leu Met Arg Thr Lys Leu Gln Ala Gln 
            180                 185                 190         


His Val Ser Tyr Arg Glu Leu Gly Ala Cys Val Arg Thr Ala Val Ala 
        195                 200                 205             


Gln Gly Gly Trp Arg Ser Leu Trp Leu Gly Trp Gly Pro Thr Ala Leu 
    210                 215                 220                 


Arg Asp Val Pro Phe Ser Ala Leu Tyr Trp Phe Asn Tyr Glu Leu Val 
225                 230                 235                 240 


Lys Ser Trp Leu Asn Gly Phe Arg Pro Lys Asp Gln Thr Ser Val Gly 
                245                 250                 255     


Met Ser Phe Val Ala Gly Gly Ile Ser Gly Thr Val Ala Ala Val Leu 
            260                 265                 270         


Thr Leu Pro Phe Asp Val Val Lys Thr Gln Arg Gln Val Ala Leu Gly 
        275                 280                 285             


Ala Met Glu Ala Val Arg Val Asn Pro Leu His Val Asp Ser Thr Trp 
    290                 295                 300                 


Leu Leu Leu Arg Arg Ile Arg Ala Glu Ser Gly Thr Lys Gly Leu Phe 
305                 310                 315                 320 


Ala Gly Phe Leu Pro Arg Ile Ile Lys Ala Ala Pro Ser Cys Ala Ile 
                325                 330                 335     


Met Ile Ser Thr Tyr Glu Phe Gly Lys Ser Phe Phe Gln Arg Leu Asn 
            340                 345                 350         


Gln Asp Arg Leu Leu Gly Gly 
        355                 


<210>  1715
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  1715

Met Cys Val Gly Glu Lys Arg Arg Ala Ile Ile Pro Ser His Leu Ala 
1               5                   10                  15      


Tyr Gly Lys Arg Gly Phe Pro Pro Ser Val Pro Ala Asp Ala Val Val 
            20                  25                  30          


Gln Tyr Asp Val Glu Leu Ile Ala Leu Ile Arg Ala Asn Tyr Trp Leu 
        35                  40                  45              


Lys Leu Val Lys Gly Ile Leu Pro Leu Val Gly Met Ala Met Val Pro 
    50                  55                  60                  


Ala Leu Leu Gly Leu Ile Gly Tyr His Leu Tyr Arg Lys Ala Asn Arg 
65                  70                  75                  80  


Pro Lys Val Ser Lys Lys Lys Leu Lys Glu Glu Lys Arg Asn Lys Ser 
                85                  90                  95      


Lys Lys Lys 
            


<210>  1716
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  1716

Met Thr Leu Arg Pro Ser Leu Leu Pro Leu His Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ala Ala Val Cys Arg Ala Glu Ala Gly Leu Glu Thr Glu 
            20                  25                  30          


Ser Pro Val Arg Thr Leu Gln Val Glu Thr Leu Val Glu Pro Pro Glu 
        35                  40                  45              


Pro Cys Ala Glu Pro Ala Ala Phe Gly Asp Thr Leu His Ile His Tyr 
    50                  55                  60                  


Thr Gly Ser Leu Val Asp Gly Arg Ile Ile Asp Thr Ser Leu Thr Arg 
65                  70                  75                  80  


Asp Pro Leu Val Ile Glu Leu Gly Gln Lys Gln Val Ile Pro Gly Leu 
                85                  90                  95      


Glu Gln Ser Leu Leu Asp Met Cys Val Gly Glu Lys Arg Arg Ala Ile 
            100                 105                 110         


Ile Pro Ser His Leu Ala Tyr Gly Lys Arg Gly Phe Pro Pro Ser Val 
        115                 120                 125             


Pro Gly Thr Lys Asp Asn Leu Met Arg Pro Pro Gly Met Thr Ser Ser 
    130                 135                 140                 


Ser Gln 
145     


<210>  1717
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  1717

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  1718
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  1718

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  1719
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  1719

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  1720
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  1720

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  1721
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  1721

Met Leu Cys Ala Ile Ser Leu Cys Ala Arg Val Arg Lys Leu Arg Ser 
1               5                   10                  15      


Ala Gly Arg Cys Gly Lys Phe His Gln Val Arg Arg Val Met Thr Ile 
            20                  25                  30          


Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met Lys Ala Ala 
        35                  40                  45              


Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu Ala Tyr Pro 
    50                  55                  60                  


Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly Pro Lys Ala 
65                  70                  75                  80  


Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu His Val Ile 
                85                  90                  95      


Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn Glu Glu Asn 
            100                 105                 110         


Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu Ser Ser Gln 
        115                 120                 125             


Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu Tyr Lys Asn 
    130                 135                 140                 


Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg His Ser Asp 
145                 150                 155                 160 


Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile Ser Glu Trp 
                165                 170                 175     


Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser Gly Gly Thr 
            180                 185                 190         


Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln Leu Lys Gln 
        195                 200                 205             


Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr Lys Glu Gly 
    210                 215                 220                 


Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys Arg Thr Thr 
225                 230                 235                 240 


Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys Arg Ile Gly 
                245                 250                 255     


Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr Leu Thr Ile 
            260                 265                 270         


Lys Arg Gly Arg 
        275     


<210>  1722
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  1722

Met Cys Gly Ala Thr Ser Phe Leu His Glu Cys Thr Arg Leu Ile Leu 
1               5                   10                  15      


Val Thr Thr Gln Asn Ala Glu Phe Leu Gln Lys Gly Leu Gln Val His 
            20                  25                  30          


Thr Cys Phe Gly Val Tyr Pro His Ala Ser Val Trp His Asp Cys Ala 
        35                  40                  45              


Ser Gln Lys Lys Gly Cys Ala Val Tyr Leu His Val Ser Val Glu Phe 
    50                  55                  60                  


Asn Lys Leu Ile Pro Glu Asn Gly Phe Ile Lys Phe His Gln Val Arg 
65                  70                  75                  80  


Arg Val Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly 
                85                  90                  95      


Cys Met Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly 
            100                 105                 110         


Gly Leu Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val 
        115                 120                 125             


Asn Gly Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr 
    130                 135                 140                 


Phe Glu His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg 
145                 150                 155                 160 


Pro Asn Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val 
                165                 170                 175     


Met Leu Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu 
            180                 185                 190         


Glu Glu Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val 
        195                 200                 205             


Arg Arg His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp 
    210                 215                 220                 


Ser Ile Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp 
225                 230                 235                 240 


Met Ser Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys 
                245                 250                 255     


Gly Gln Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly 
            260                 265                 270         


Tyr Thr Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser 
        275                 280                 285             


Gln Cys Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser 
    290                 295                 300                 


Lys Lys Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val 
305                 310                 315                 320 


Cys Thr Leu Thr Ile Lys Arg Gly Arg 
                325                 


<210>  1723
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  1723

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  1724
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  1724

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  1725
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  1725

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  1726
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  1726

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  1727
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  1727

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  1728
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  1728

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  1729
<211>  888
<212>  PRT
<213>  Homo sapiens

<400>  1729

Met Glu Ser Cys Tyr Ile Ala Gln Ala Gly Leu Glu Leu Leu Gly Ser 
1               5                   10                  15      


Ser Ser Ser Pro Thr Leu Thr Ser Gln Ser Ala Glu Ile Thr Glu Asp 
            20                  25                  30          


Ala Ser Asn Gly Gly Val Ser Glu Gln His Pro Trp Pro Ser Gly Phe 
        35                  40                  45              


Glu Arg Glu Leu Lys Pro Glu Thr Ile Ser Ser Pro Gly Tyr His Ile 
    50                  55                  60                  


Leu Arg Ala Thr Gly Glu Glu Asn Met Ala Val Ser Leu Asp Asp Asp 
65                  70                  75                  80  


Val Pro Leu Ile Leu Thr Leu Asp Glu Gly Gly Ser Ala Pro Leu Ala 
                85                  90                  95      


Pro Ser Asn Gly Leu Gly Gln Glu Glu Leu Pro Ser Lys Asn Gly Gly 
            100                 105                 110         


Ser Tyr Ala Ile His Asp Ser Gln Ala Pro Ser Leu Ser Ser Gly Gly 
        115                 120                 125             


Glu Ser Ser Pro Ser Ser Pro Ala His Asn Trp Glu Met Asn Tyr Gln 
    130                 135                 140                 


Glu Ala Ala Ile Tyr Leu Gln Glu Gly Glu Asn Asn Asp Lys Phe Phe 
145                 150                 155                 160 


Thr His Pro Lys Asp Ala Lys Ala Leu Ala Ala Tyr Leu Phe Ala His 
                165                 170                 175     


Asn His Leu Phe Tyr Leu Met Glu Leu Ala Thr Ala Leu Leu Leu Leu 
            180                 185                 190         


Leu Leu Ser Leu Cys Glu Ala Pro Ala Val Pro Ala Leu Arg Leu Gly 
        195                 200                 205             


Ile Tyr Val His Ala Thr Leu Glu Leu Phe Ala Leu Met Val Val Val 
    210                 215                 220                 


Phe Glu Leu Cys Met Lys Leu Arg Trp Leu Gly Leu His Thr Phe Ile 
225                 230                 235                 240 


Arg His Lys Arg Thr Met Val Lys Thr Ser Val Leu Val Val Gln Phe 
                245                 250                 255     


Val Glu Ala Ile Val Val Leu Val Arg Gln Met Ser His Val Arg Val 
            260                 265                 270         


Thr Arg Ala Leu Arg Cys Ile Phe Leu Val Asp Cys Arg Tyr Cys Gly 
        275                 280                 285             


Gly Val Arg Arg Asn Leu Arg Gln Ile Phe Gln Ser Leu Pro Pro Phe 
    290                 295                 300                 


Met Asp Ile Leu Leu Leu Leu Leu Phe Phe Met Ile Ile Phe Ala Ile 
305                 310                 315                 320 


Leu Gly Phe Tyr Leu Phe Ser Pro Asn Pro Ser Asp Pro Tyr Phe Ser 
                325                 330                 335     


Thr Leu Glu Asn Ser Ile Val Ser Leu Phe Val Leu Leu Thr Thr Ala 
            340                 345                 350         


Asn Phe Pro Asp Val Met Met Pro Ser Tyr Ser Arg Asn Pro Trp Ser 
        355                 360                 365             


Cys Val Phe Phe Ile Val Tyr Leu Ser Ile Glu Leu Tyr Phe Ile Met 
    370                 375                 380                 


Asn Leu Leu Leu Ala Val Val Phe Asp Thr Phe Asn Asp Ile Glu Lys 
385                 390                 395                 400 


Arg Lys Phe Lys Ser Leu Leu Leu His Lys Arg Thr Ala Ile Gln His 
                405                 410                 415     


Ala Tyr Arg Leu Leu Ile Ser Gln Arg Arg Pro Ala Gly Ile Ser Tyr 
            420                 425                 430         


Arg Gln Phe Glu Gly Leu Met Arg Phe Tyr Lys Pro Arg Met Ser Ala 
        435                 440                 445             


Arg Glu Arg Tyr Leu Thr Phe Lys Ala Leu Asn Gln Asn Asn Thr Pro 
    450                 455                 460                 


Leu Leu Ser Leu Lys Asp Phe Tyr Asp Ile Tyr Glu Val Ala Ala Leu 
465                 470                 475                 480 


Lys Trp Lys Ala Lys Lys Asn Arg Glu His Trp Phe Asp Glu Leu Pro 
                485                 490                 495     


Arg Thr Ala Leu Leu Ile Phe Lys Gly Ile Asn Ile Leu Val Lys Ser 
            500                 505                 510         


Lys Ala Phe Gln Tyr Phe Met Tyr Leu Val Val Ala Val Asn Gly Val 
        515                 520                 525             


Trp Ile Leu Val Glu Thr Phe Met Leu Lys Gly Gly Asn Phe Phe Ser 
    530                 535                 540                 


Lys His Val Pro Trp Ser Tyr Leu Val Phe Leu Thr Ile Tyr Gly Val 
545                 550                 555                 560 


Glu Leu Phe Leu Lys Val Ala Gly Leu Gly Pro Val Glu Tyr Leu Ser 
                565                 570                 575     


Ser Gly Trp Asn Leu Phe Asp Phe Ser Val Thr Val Phe Ala Phe Leu 
            580                 585                 590         


Gly Leu Leu Ala Leu Ala Leu Asn Met Glu Pro Phe Tyr Phe Ile Val 
        595                 600                 605             


Val Leu Arg Pro Leu Gln Leu Leu Arg Leu Phe Lys Leu Lys Glu Arg 
    610                 615                 620                 


Tyr Arg Asn Val Leu Asp Thr Met Phe Glu Leu Leu Pro Arg Met Ala 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Leu Leu Ile Phe Tyr Tyr Ser Phe Ala Ile Val 
                645                 650                 655     


Gly Met Glu Phe Phe Cys Gly Ile Val Phe Pro Asn Cys Cys Asn Thr 
            660                 665                 670         


Ser Thr Val Ala Asp Ala Tyr Arg Trp Arg Asn His Thr Val Gly Asn 
        675                 680                 685             


Arg Thr Val Val Glu Glu Gly Tyr Tyr Tyr Leu Asn Asn Phe Asp Asn 
    690                 695                 700                 


Ile Leu Asn Ser Phe Val Thr Leu Phe Glu Leu Thr Val Val Asn Asn 
705                 710                 715                 720 


Trp Tyr Ile Ile Met Glu Gly Val Thr Ser Gln Thr Ser His Trp Ser 
                725                 730                 735     


Arg Leu Tyr Phe Met Thr Phe Tyr Ile Val Thr Met Val Val Met Thr 
            740                 745                 750         


Ile Ile Val Ala Phe Ile Leu Glu Ala Phe Val Phe Arg Met Asn Tyr 
        755                 760                 765             


Ser Arg Lys Asn Gln Asp Ser Glu Val Asp Gly Gly Ile Thr Leu Glu 
    770                 775                 780                 


Lys Glu Ile Ser Lys Glu Glu Leu Val Ala Val Leu Glu Leu Tyr Arg 
785                 790                 795                 800 


Glu Ala Arg Gly Ala Ser Ser Asp Val Thr Arg Leu Leu Glu Thr Leu 
                805                 810                 815     


Ser Gln Met Glu Arg Tyr Gln Gln His Ser Met Val Phe Leu Gly Arg 
            820                 825                 830         


Arg Ser Arg Thr Lys Ser Asp Leu Ser Leu Lys Met Tyr Gln Glu Glu 
        835                 840                 845             


Ile Gln Glu Trp Tyr Glu Glu His Ala Arg Glu Gln Glu Gln Gln Arg 
    850                 855                 860                 


Gln Leu Ser Ser Ser Ala Ala Pro Ala Ala Gln Gln Pro Pro Gly Ser 
865                 870                 875                 880 


Arg Gln Arg Ser Gln Thr Val Thr 
                885             


<210>  1730
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  1730

Met Pro Asp Thr Asn Ser Thr Ile Asn Leu Ser Leu Ser Thr Arg Val 
1               5                   10                  15      


Thr Leu Ala Phe Phe Met Ser Leu Val Ala Phe Ala Ile Met Leu Gly 
            20                  25                  30          


Asn Ala Leu Val Ile Leu Ala Phe Val Val Asp Lys Asn Leu Arg His 
        35                  40                  45              


Arg Ser Ser Tyr Phe Phe Leu Asn Leu Ala Ile Ser Asp Phe Phe Val 
    50                  55                  60                  


Val Ser Glu Ser Trp Lys Asp Glu Gly Ser Glu Cys Glu Pro Gly Phe 
65                  70                  75                  80  


Phe Ser Glu Trp Tyr Ile Leu Ala Ile Thr Ser Phe Leu Glu Phe Val 
                85                  90                  95      


Ile Pro Val Ile Leu Val Ala Tyr Phe Asn Met Asn Ile Tyr Trp Ser 
            100                 105                 110         


Leu Trp Lys Arg Asp His Leu Ser Arg Cys Gln Ser His Pro Gly Leu 
        115                 120                 125             


Thr Ala Val Ser Ser Asn Ile Cys Gly His Ser Phe Arg Gly Arg Leu 
    130                 135                 140                 


Ser Ser Arg Arg Ser Leu Ser Ala Ser Thr Glu Val Pro Ala Ser Phe 
145                 150                 155                 160 


His Ser Glu Arg Gln Arg Arg Lys Ser Ser Leu Met Phe Ser Ser Arg 
                165                 170                 175     


Thr Lys Met Asn Ser Asn Thr Ile Ala Ser Lys Met Gly Ser Phe Ser 
            180                 185                 190         


Gln Ser Asp Ser Val Ala Leu His Gln Arg Glu His Val Glu Leu Leu 
        195                 200                 205             


Arg Ala Arg Arg Leu Ala Lys Ser Leu Ala Ile Leu Leu Gly Val Phe 
    210                 215                 220                 


Ala Val Cys Trp Ala Pro Tyr Ser Leu Phe Thr Ile Val Leu Ser Phe 
225                 230                 235                 240 


Tyr Ser Ser Ala Thr Gly Pro Lys Ser Val Trp Tyr Arg Ile Ala Phe 
                245                 250                 255     


Trp Leu Gln Trp Phe Asn Ser Phe Val Asn Pro Leu Leu Tyr Pro Leu 
            260                 265                 270         


Cys His Lys Arg Phe Gln Lys Ala Phe Leu Lys Ile Phe Cys Ile Lys 
        275                 280                 285             


Lys Gln Pro Leu Pro Ser Gln His Ser Arg Ser Val Ser Ser 
    290                 295                 300         


<210>  1731
<211>  1212
<212>  PRT
<213>  Homo sapiens

<400>  1731

Met Val Leu Leu Leu Ile Leu Ser Val Leu Leu Leu Lys Glu Asp Val 
1               5                   10                  15      


Arg Gly Ser Ala Gln Ser Ser Glu Arg Arg Val Val Ala His Met Pro 
            20                  25                  30          


Gly Asp Ile Ile Ile Gly Ala Leu Phe Ser Val His His Gln Pro Thr 
        35                  40                  45              


Val Asp Lys Val His Glu Arg Lys Cys Gly Ala Val Arg Glu Gln Tyr 
    50                  55                  60                  


Gly Ile Gln Arg Val Glu Ala Met Leu His Thr Leu Glu Arg Ile Asn 
65                  70                  75                  80  


Ser Asp Pro Thr Leu Leu Pro Asn Ile Thr Leu Gly Cys Glu Ile Arg 
                85                  90                  95      


Asp Ser Cys Trp His Ser Ala Val Ala Leu Glu Gln Ser Ile Glu Phe 
            100                 105                 110         


Ile Arg Asp Ser Leu Ile Ser Ser Glu Glu Glu Glu Gly Leu Val Arg 
        115                 120                 125             


Cys Val Asp Gly Ser Ser Ser Ser Phe Arg Ser Lys Lys Pro Ile Val 
    130                 135                 140                 


Gly Val Ile Gly Pro Gly Ser Ser Ser Val Ala Ile Gln Val Gln Asn 
145                 150                 155                 160 


Leu Leu Gln Leu Phe Asn Ile Pro Gln Ile Ala Tyr Ser Ala Thr Ser 
                165                 170                 175     


Met Asp Leu Ser Asp Lys Thr Leu Phe Lys Tyr Phe Met Arg Val Val 
            180                 185                 190         


Pro Ser Asp Ala Gln Gln Ala Arg Ala Met Val Asp Ile Val Lys Arg 
        195                 200                 205             


Tyr Asn Trp Thr Tyr Val Ser Ala Val His Thr Glu Gly Asn Tyr Gly 
    210                 215                 220                 


Glu Ser Gly Met Glu Ala Phe Lys Asp Met Ser Ala Lys Glu Gly Ile 
225                 230                 235                 240 


Cys Ile Ala His Ser Tyr Lys Ile Tyr Ser Asn Ala Gly Glu Gln Ser 
                245                 250                 255     


Phe Asp Lys Leu Leu Lys Lys Leu Thr Ser His Leu Pro Lys Ala Arg 
            260                 265                 270         


Val Val Ala Cys Phe Cys Glu Gly Met Thr Val Arg Gly Leu Leu Met 
        275                 280                 285             


Ala Met Arg Arg Leu Gly Leu Ala Gly Glu Phe Leu Leu Leu Gly Ser 
    290                 295                 300                 


Asp Gly Trp Ala Asp Arg Tyr Asp Val Thr Asp Gly Tyr Gln Arg Glu 
305                 310                 315                 320 


Ala Val Gly Gly Ile Thr Ile Lys Leu Gln Ser Pro Asp Val Lys Trp 
                325                 330                 335     


Phe Asp Asp Tyr Tyr Leu Lys Leu Arg Pro Glu Thr Asn His Arg Asn 
            340                 345                 350         


Pro Trp Phe Gln Glu Phe Trp Gln His Arg Phe Gln Cys Arg Leu Glu 
        355                 360                 365             


Gly Phe Pro Gln Glu Asn Ser Lys Tyr Asn Lys Thr Cys Asn Ser Ser 
    370                 375                 380                 


Leu Thr Leu Lys Thr His His Val Gln Asp Ser Lys Met Gly Phe Val 
385                 390                 395                 400 


Ile Asn Ala Ile Tyr Ser Met Ala Tyr Gly Leu His Asn Met Gln Met 
                405                 410                 415     


Ser Leu Cys Pro Gly Tyr Ala Gly Leu Cys Asp Ala Met Lys Pro Ile 
            420                 425                 430         


Asp Gly Arg Lys Leu Leu Glu Ser Leu Met Lys Thr Asn Phe Thr Gly 
        435                 440                 445             


Val Ser Gly Asp Thr Ile Leu Phe Asp Glu Asn Gly Asp Ser Pro Gly 
    450                 455                 460                 


Arg Tyr Glu Ile Met Asn Phe Lys Glu Met Gly Lys Asp Tyr Phe Asp 
465                 470                 475                 480 


Tyr Ile Asn Val Gly Ser Trp Asp Asn Gly Glu Leu Lys Met Asp Asp 
                485                 490                 495     


Asp Glu Val Trp Ser Lys Lys Ser Asn Ile Ile Arg Ser Val Cys Ser 
            500                 505                 510         


Glu Pro Cys Glu Lys Gly Gln Ile Lys Val Ile Arg Lys Gly Glu Val 
        515                 520                 525             


Ser Cys Cys Trp Thr Cys Thr Pro Cys Lys Glu Asn Glu Tyr Val Phe 
    530                 535                 540                 


Asp Glu Tyr Thr Cys Lys Ala Cys Gln Leu Gly Ser Trp Pro Thr Asp 
545                 550                 555                 560 


Asp Leu Thr Gly Cys Asp Leu Ile Pro Val Gln Tyr Leu Arg Trp Gly 
                565                 570                 575     


Asp Pro Glu Pro Ile Ala Ala Val Val Phe Ala Cys Leu Gly Leu Leu 
            580                 585                 590         


Ala Thr Leu Phe Val Thr Val Val Phe Ile Ile Tyr Arg Asp Thr Pro 
        595                 600                 605             


Val Val Lys Ser Ser Ser Arg Glu Leu Cys Tyr Ile Ile Leu Ala Gly 
    610                 615                 620                 


Ile Cys Leu Gly Tyr Leu Cys Thr Phe Cys Leu Ile Ala Lys Pro Lys 
625                 630                 635                 640 


Gln Ile Tyr Cys Tyr Leu Gln Arg Ile Gly Ile Gly Leu Ser Pro Ala 
                645                 650                 655     


Met Ser Tyr Ser Ala Leu Val Thr Lys Thr Asn Arg Ile Ala Arg Ile 
            660                 665                 670         


Leu Ala Gly Ser Lys Lys Lys Ile Cys Thr Lys Lys Pro Arg Phe Met 
        675                 680                 685             


Ser Ala Cys Ala Gln Leu Val Ile Ala Phe Ile Leu Ile Cys Ile Gln 
    690                 695                 700                 


Leu Gly Ile Ile Val Ala Leu Phe Ile Met Glu Pro Pro Asp Ile Met 
705                 710                 715                 720 


His Asp Tyr Pro Ser Ile Arg Glu Val Tyr Leu Ile Cys Asn Thr Thr 
                725                 730                 735     


Asn Leu Gly Val Val Thr Pro Leu Gly Tyr Asn Gly Leu Leu Ile Leu 
            740                 745                 750         


Ser Cys Thr Phe Tyr Ala Phe Lys Thr Arg Asn Val Pro Ala Asn Phe 
        755                 760                 765             


Asn Glu Ala Lys Tyr Ile Ala Phe Thr Met Tyr Thr Thr Cys Ile Ile 
    770                 775                 780                 


Trp Leu Ala Phe Val Pro Ile Tyr Phe Gly Ser Asn Tyr Lys Ile Ile 
785                 790                 795                 800 


Thr Met Cys Phe Ser Val Ser Leu Ser Ala Thr Val Ala Leu Gly Cys 
                805                 810                 815     


Met Phe Val Pro Lys Val Tyr Ile Ile Leu Ala Lys Pro Glu Arg Asn 
            820                 825                 830         


Val Arg Ser Ala Phe Thr Thr Ser Thr Val Val Arg Met His Val Gly 
        835                 840                 845             


Asp Gly Lys Ser Ser Ser Ala Ala Ser Arg Ser Ser Ser Leu Val Asn 
    850                 855                 860                 


Leu Trp Lys Arg Arg Gly Ser Ser Gly Glu Thr Leu Arg Tyr Lys Asp 
865                 870                 875                 880 


Arg Arg Leu Ala Gln His Lys Ser Glu Ile Glu Cys Phe Thr Pro Lys 
                885                 890                 895     


Gly Ser Met Gly Asn Gly Gly Arg Ala Thr Met Ser Ser Ser Asn Gly 
            900                 905                 910         


Lys Ser Val Thr Trp Ala Gln Asn Glu Lys Ser Ser Arg Gly Gln His 
        915                 920                 925             


Leu Trp Gln Arg Leu Ser Ile His Ile Asn Lys Lys Glu Asn Pro Asn 
    930                 935                 940                 


Gln Thr Ala Val Ile Lys Pro Phe Pro Lys Ser Thr Glu Ser Arg Gly 
945                 950                 955                 960 


Leu Gly Ala Gly Ala Gly Ala Gly Gly Ser Ala Gly Gly Val Gly Ala 
                965                 970                 975     


Thr Gly Gly Ala Gly Cys Ala Gly Ala Gly Pro Gly Gly Pro Glu Ser 
            980                 985                 990         


Pro Asp Ala Gly Pro Lys Ala Leu  Tyr Asp Val Ala Glu  Ala Glu Glu 
        995                 1000                 1005             


His Phe  Pro Ala Pro Ala Arg  Pro Arg Ser Pro Ser  Pro Ile Ser 
    1010                 1015                 1020             


Thr Leu  Ser His Arg Ala Gly  Ser Ala Ser Arg Thr  Asp Asp Asp 
    1025                 1030                 1035             


Val Pro  Ser Leu His Ser Glu  Pro Val Ala Arg Ser  Ser Ser Ser 
    1040                 1045                 1050             


Gln Gly  Ser Leu Met Glu Gln  Ile Ser Ser Val Val  Thr Arg Phe 
    1055                 1060                 1065             


Thr Ala  Asn Ile Ser Glu Leu  Asn Ser Met Met Leu  Ser Thr Ala 
    1070                 1075                 1080             


Ala Pro  Ser Pro Gly Val Gly  Ala Pro Leu Cys Ser  Ser Tyr Leu 
    1085                 1090                 1095             


Ile Pro  Lys Glu Ile Gln Leu  Pro Thr Thr Met Thr  Thr Phe Ala 
    1100                 1105                 1110             


Glu Ile  Gln Pro Leu Pro Ala  Ile Glu Val Thr Gly  Gly Ala Gln 
    1115                 1120                 1125             


Pro Ala  Ala Gly Ala Gln Ala  Ala Gly Asp Ala Ala  Arg Glu Ser 
    1130                 1135                 1140             


Pro Ala  Ala Gly Pro Glu Ala  Ala Ala Ala Lys Pro  Asp Leu Glu 
    1145                 1150                 1155             


Glu Leu  Val Ala Leu Thr Pro  Pro Ser Pro Phe Arg  Asp Ser Val 
    1160                 1165                 1170             


Asp Ser  Gly Ser Thr Thr Pro  Asn Ser Pro Val Ser  Glu Ser Ala 
    1175                 1180                 1185             


Leu Cys  Ile Pro Ser Ser Pro  Lys Tyr Asp Thr Leu  Ile Ile Arg 
    1190                 1195                 1200             


Asp Tyr  Thr Gln Ser Ser Ser  Ser Leu 
    1205                 1210         


<210>  1732
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  1732

Met Ala Ser Ala Leu Ser Tyr Val Ser Lys Phe Lys Ser Phe Val Ile 
1               5                   10                  15      


Leu Phe Val Thr Pro Leu Leu Leu Leu Pro Leu Val Ile Leu Met Pro 
            20                  25                  30          


Ala Lys Phe Val Arg Cys Ala Tyr Val Ile Ile Leu Met Ala Ile Tyr 
        35                  40                  45              


Trp Cys Thr Glu Val Ile Pro Leu Ala Val Thr Ser Leu Met Pro Val 
    50                  55                  60                  


Leu Leu Phe Pro Leu Phe Gln Ile Leu Asp Ser Arg Gln Val Cys Val 
65                  70                  75                  80  


Gln Tyr Met Lys Asp Thr Asn Met Leu Phe Leu Gly Gly Leu Ile Val 
                85                  90                  95      


Ala Val Ala Val Glu Arg Trp Asn Leu His Lys Arg Ile Ala Leu Arg 
            100                 105                 110         


Thr Leu Leu Trp Val Gly Ala Lys Pro Ala Arg Leu Met Leu Gly Phe 
        115                 120                 125             


Met Gly Val Thr Ala Leu Leu Ser Met Trp Ile Ser Asn Thr Ala Thr 
    130                 135                 140                 


Thr Ala Met Met Val Pro Ile Val Glu Ala Ile Leu Gln Gln Met Glu 
145                 150                 155                 160 


Ala Thr Ser Ala Ala Thr Glu Ala Gly Leu Glu Leu Val Asp Lys Gly 
                165                 170                 175     


Lys Ala Lys Glu Leu Pro Gly Ser Gln Val Ile Phe Glu Gly Pro Thr 
            180                 185                 190         


Leu Gly Gln Gln Glu Asp Gln Glu Arg Lys Arg Leu Cys Lys Ala Met 
        195                 200                 205             


Thr Leu Cys Ile Cys Tyr Ala Ala Ser Ile Gly Gly Thr Ala Thr Leu 
    210                 215                 220                 


Thr Gly Thr Gly Pro Asn Val Val Leu Leu Gly Gln Met Asn Glu Leu 
225                 230                 235                 240 


Phe Pro Asp Ser Lys Asp Leu Val Asn Phe Ala Ser Trp Phe Ala Phe 
                245                 250                 255     


Ala Phe Pro Asn Met Leu Val Met Leu Leu Phe Ala Trp Leu Trp Leu 
            260                 265                 270         


Gln Phe Val Tyr Met Arg Phe Asn Phe Lys Lys Ser Trp Gly Cys Gly 
        275                 280                 285             


Leu Glu Ser Lys Lys Asn Glu Lys Ala Ala Leu Lys Val Leu Gln Glu 
    290                 295                 300                 


Glu Tyr Arg Lys Leu Gly Pro Leu Ser Phe Ala Glu Ile Asn Val Leu 
305                 310                 315                 320 


Ile Cys Phe Phe Leu Leu Val Ile Leu Trp Phe Ser Arg Asp Pro Gly 
                325                 330                 335     


Phe Met Pro Gly Trp Leu Thr Val Ala Trp Val Glu Gly Glu Thr Lys 
            340                 345                 350         


Tyr Val Ser Asp Ala Thr Val Ala Ile Phe Val Ala Thr Leu Leu Phe 
        355                 360                 365             


Ile Val Pro Ser Gln Lys Pro Lys Phe Asn Phe Arg Ser Gln Thr Glu 
    370                 375                 380                 


Glu Glu Arg Lys Thr Pro Phe Tyr Pro Pro Pro Leu Leu Asp Trp Lys 
385                 390                 395                 400 


Val Thr Gln Glu Lys Val Pro Trp Gly Ile Val Leu Leu Leu Gly Gly 
                405                 410                 415     


Gly Phe Ala Leu Ala Lys Gly Ser Glu Ala Ser Gly Leu Ser Val Trp 
            420                 425                 430         


Met Gly Lys Gln Met Glu Pro Leu His Ala Val Pro Pro Ala Ala Ile 
        435                 440                 445             


Thr Leu Ile Leu Ser Leu Leu Val Ala Val Phe Thr Glu Cys Thr Ser 
    450                 455                 460                 


Asn Val Ala Thr Thr Thr Leu Phe Leu Pro Ile Phe Ala Ser Met Val 
465                 470                 475                 480 


Lys Thr Gly Val Ile Met Asn Ile Ile Gly Val Phe Cys Val Phe Leu 
                485                 490                 495     


Ala Val Asn Thr Trp Gly Arg Ala Ile Phe Asp Leu Asp His Phe Pro 
            500                 505                 510         


Asp Trp Ala Asn Val Thr His Ile Glu Thr 
        515                 520         


<210>  1733
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  1733

Met Gly Ser Gln His Ser Ala Ala Ala Arg Pro Ser Ser Cys Arg Arg 
1               5                   10                  15      


Lys Gln Glu Asp Asp Arg Asp Gly Leu Leu Ala Glu Arg Glu Gln Glu 
            20                  25                  30          


Glu Ala Ile Ala Gln Phe Pro Tyr Val Glu Phe Thr Gly Arg Asp Ser 
        35                  40                  45              


Ile Thr Cys Leu Thr Cys Gln Gly Thr Gly Tyr Ile Pro Thr Glu Gln 
    50                  55                  60                  


Val Asn Glu Leu Val Ala Leu Ile Pro His Ser Asp Gln Arg Leu Arg 
65                  70                  75                  80  


Pro Gln Arg Thr Lys Gln Tyr Val Leu Leu Ser Ile Leu Leu Cys Leu 
                85                  90                  95      


Leu Ala Ser Gly Leu Val Val Phe Phe Leu Phe Pro His Ser Val Leu 
            100                 105                 110         


Val Asp Asp Asp Gly Ile Lys Val Val Lys Val Thr Phe Asn Lys Gln 
        115                 120                 125             


Asp Ser Leu Val Ile Leu Thr Ile Met Ala Thr Leu Lys Ile Arg Asn 
    130                 135                 140                 


Ser Asn Phe Tyr Thr Val Ala Val Thr Ser Leu Ser Ser Gln Ile Gln 
145                 150                 155                 160 


Tyr Met Asn Thr Val Val Asn Phe Thr Gly Lys Ala Glu Met Gly Gly 
                165                 170                 175     


Pro Phe Ser Tyr Val Tyr Phe Phe Cys Thr Val Pro Glu Ile Leu Val 
            180                 185                 190         


His Asn Ile Val Ile Phe Met Arg Thr Ser Val Lys Ile Ser Tyr Ile 
        195                 200                 205             


Gly Leu Met Thr Gln Ser Ser Leu Glu Thr His His Tyr Val Asp Cys 
    210                 215                 220                 


Gly Gly Asn Ser Thr Ala Ile 
225                 230     


<210>  1734
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  1734

Met Gly Ser Gln His Ser Ala Ala Ala Arg Pro Ser Ser Cys Arg Arg 
1               5                   10                  15      


Lys Gln Glu Asp Asp Arg Asp Gly Leu Leu Ala Glu Arg Glu Gln Glu 
            20                  25                  30          


Glu Ala Ile Ala Gln Phe Pro Tyr Val Glu Phe Thr Gly Arg Asp Ser 
        35                  40                  45              


Ile Thr Cys Leu Thr Cys Gln Gly Thr Gly Tyr Ile Pro Thr Glu Gln 
    50                  55                  60                  


Val Asn Glu Leu Val Ala Leu Ile Pro His Ser Asp Gln Arg Leu Arg 
65                  70                  75                  80  


Pro Gln Arg Thr Lys Gln Tyr Val Leu Leu Ser Ile Leu Leu Cys Leu 
                85                  90                  95      


Leu Ala Ser Gly Leu Val Val Phe Phe Leu Phe Pro His Ser Val Leu 
            100                 105                 110         


Val Asp Asp Asp Gly Ile Lys Val Val Lys Val Thr Phe Asn Lys Gln 
        115                 120                 125             


Asp Ser Leu Val Ile Leu Thr Ile Met Ala Thr Leu Lys Ile Arg Asn 
    130                 135                 140                 


Ser Asn Phe Tyr Thr Val Ala Val Thr Ser Leu Ser Ser Gln Ile Gln 
145                 150                 155                 160 


Tyr Met Asn Thr Val Val Ser Thr Tyr Val Thr Thr Asn Val Ser Leu 
                165                 170                 175     


Ile Pro Pro Arg Ser Glu Gln Leu Val Asn Phe Thr Gly Lys Ala Glu 
            180                 185                 190         


Met Gly Gly Pro Phe Ser Tyr Val Tyr Phe Phe Cys Thr Val Pro Glu 
        195                 200                 205             


Ile Leu Val His Asn Ile Val Ile Phe Met Arg Thr Ser Val Lys Ile 
    210                 215                 220                 


Ser Tyr Ile Gly Leu Met Thr Gln Ser Ser Leu Glu Thr His His Tyr 
225                 230                 235                 240 


Val Asp Cys Gly Gly Asn Ser Thr Ala Ile 
                245                 250 


<210>  1735
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  1735

Met Gly Ser Gln His Ser Ala Ala Ala Arg Pro Ser Ser Cys Arg Arg 
1               5                   10                  15      


Lys Gln Glu Asp Asp Arg Asp Gly Leu Leu Ala Glu Arg Glu Gln Glu 
            20                  25                  30          


Glu Ala Ile Ala Gln Phe Pro Tyr Val Glu Phe Thr Gly Arg Asp Ser 
        35                  40                  45              


Ile Thr Cys Leu Thr Cys Gln Gly Thr Gly Tyr Ile Pro Thr Glu Gln 
    50                  55                  60                  


Val Asn Glu Leu Val Ala Leu Ile Pro His Ser Asp Gln Arg Leu Arg 
65                  70                  75                  80  


Pro Gln Arg Thr Lys Gln Tyr Val Leu Leu Ser Ile Leu Leu Cys Leu 
                85                  90                  95      


Leu Ala Ser Gly Leu Val Val Phe Phe Leu Phe Pro His Ser Val Leu 
            100                 105                 110         


Val Asp Asp Asp Gly Ile Lys Val Val Lys Val Thr Phe Asn Lys Gln 
        115                 120                 125             


Asp Ser Leu Val Ile Leu Thr Ile Met Ala Thr Leu Lys Ile Arg Asn 
    130                 135                 140                 


Ser Asn Phe Tyr Thr Val Ala Val Thr Ser Leu Ser Ser Gln Ile Gln 
145                 150                 155                 160 


Tyr Met Asn Thr Val Val Asn Phe Thr Gly Lys Ala Glu Met Gly Gly 
                165                 170                 175     


Pro Phe Ser Tyr Val Tyr Phe Phe Cys Thr Val Pro Glu Ile Leu Val 
            180                 185                 190         


His Asn Ile Val Ile Phe Met Arg Thr Ser Val Lys Ile Ser Tyr Ile 
        195                 200                 205             


Gly Leu Met Thr Gln Ser Ser Leu Glu Thr His His Tyr Val Asp Cys 
    210                 215                 220                 


Gly Gly Asn Ser Thr Ala Ile 
225                 230     


<210>  1736
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  1736

Met Asn Thr Thr Ser Ser Ala Ala Pro Pro Ser Leu Gly Val Glu Phe 
1               5                   10                  15      


Ile Ser Leu Leu Ala Ile Ile Leu Leu Ser Val Ala Leu Ala Val Gly 
            20                  25                  30          


Leu Pro Gly Asn Ser Phe Val Val Trp Ser Ile Leu Lys Arg Met Gln 
        35                  40                  45              


Lys Arg Ser Val Thr Ala Leu Met Val Leu Asn Leu Ala Leu Ala Asp 
    50                  55                  60                  


Leu Ala Val Leu Leu Thr Ala Pro Phe Phe Leu His Phe Leu Ala Gln 
65                  70                  75                  80  


Gly Thr Trp Ser Phe Gly Leu Ala Gly Cys Arg Leu Cys His Tyr Val 
                85                  90                  95      


Cys Gly Val Ser Met Tyr Ala Ser Val Leu Leu Ile Thr Ala Met Ser 
            100                 105                 110         


Leu Asp Arg Ser Leu Ala Val Ala Arg Pro Phe Val Ser Gln Lys Leu 
        115                 120                 125             


Arg Thr Lys Ala Met Ala Arg Arg Val Leu Ala Gly Ile Trp Val Leu 
    130                 135                 140                 


Ser Phe Leu Leu Ala Thr Pro Val Leu Ala Tyr Arg Thr Val Val Pro 
145                 150                 155                 160 


Trp Lys Thr Asn Met Ser Leu Cys Phe Pro Arg Tyr Pro Ser Glu Gly 
                165                 170                 175     


His Arg Ala Phe His Leu Ile Phe Glu Ala Val Thr Gly Phe Leu Leu 
            180                 185                 190         


Pro Phe Leu Ala Val Val Ala Ser Tyr Ser Asp Ile Gly Arg Arg Leu 
        195                 200                 205             


Gln Ala Arg Arg Phe Arg Arg Ser Arg Arg Thr Gly Arg Leu Val Val 
    210                 215                 220                 


Leu Ile Ile Leu Thr Phe Ala Ala Phe Trp Leu Pro Tyr His Val Val 
225                 230                 235                 240 


Asn Leu Ala Glu Ala Gly Arg Ala Leu Ala Gly Gln Ala Ala Gly Leu 
                245                 250                 255     


Gly Leu Val Gly Lys Arg Leu Ser Leu Ala Arg Asn Val Leu Ile Ala 
            260                 265                 270         


Leu Ala Phe Leu Ser Ser Ser Val Asn Pro Val Leu Tyr Ala Cys Ala 
        275                 280                 285             


Gly Gly Gly Leu Leu Arg Ser Ala Gly Val Gly Phe Val Ala Lys Leu 
    290                 295                 300                 


Leu Glu Gly Thr Gly Ser Glu Ala Ser Ser Thr Arg Arg Gly Gly Ser 
305                 310                 315                 320 


Leu Gly Gln Thr Ala Arg Ser Gly Pro Ala Ala Leu Glu Pro Gly Pro 
                325                 330                 335     


Ser Glu Ser Leu Thr Ala Ser Ser Pro Leu Lys Leu Asn Glu Leu Asn 
            340                 345                 350         


<210>  1737
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  1737

Met Glu Ala Gln Glu Tyr Ile Ala Asn Val Thr Ser Ser Ser Ser Ala 
1               5                   10                  15      


Lys Phe Glu Ala Ala Leu Thr Trp Ile Leu Ser Ser Asn Lys Asp Val 
            20                  25                  30          


Gly Ile Trp Leu Lys Gly Glu Asp Gln Ser Glu Leu Val Thr Thr Val 
        35                  40                  45              


Asp Lys Val Val Cys Leu Glu Ser Ala His Pro Arg Met Gly Val Gly 
    50                  55                  60                  


Cys Arg Leu Ser Arg Ala Leu Leu Thr Ala Val Thr Asn Val Leu Ile 
65                  70                  75                  80  


Phe Phe Trp Cys Leu Ala Phe Leu Trp Gly Leu Leu Ile Leu Leu Lys 
                85                  90                  95      


Tyr Arg Trp Arg Lys Leu Glu Glu Glu Glu Gln Ala Met Tyr Glu Met 
            100                 105                 110         


Val Lys Lys Ile Ile Asp Val Val Gln Asp His Tyr Val Asp Trp Glu 
        115                 120                 125             


Gln Asp Met Glu Arg Tyr Pro Tyr Val Gly Ile Leu His Val Arg Asp 
    130                 135                 140                 


Ser Leu Ile Pro Pro Gln Ser Arg Arg Arg Met Lys Arg Val Trp Asp 
145                 150                 155                 160 


Arg Ala Val Glu Phe Leu Ala Ser Asn Glu Ser Arg Ile Gln Thr Glu 
                165                 170                 175     


Ser His Arg Val Ala Gly Glu Asp Met Leu Val Trp Arg Trp Thr Lys 
            180                 185                 190         


Pro Ser Ser Phe Ser Asp Ser Glu Arg 
        195                 200     


<210>  1738
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  1738

Met Thr Lys Thr Ser Thr Cys Ile Tyr His Phe Leu Val Leu Ser Trp 
1               5                   10                  15      


Tyr Thr Phe Leu Asn Tyr Tyr Ile Ser Gln Glu Gly Lys Asp Glu Val 
            20                  25                  30          


Lys Pro Lys Ile Leu Ala Asn Gly Ala Arg Trp Lys Tyr Met Thr Leu 
        35                  40                  45              


Leu Asn Leu Leu Lys Asn Arg Thr Ala Gly Phe Asp Ile Tyr Gln Pro 
    50                  55                  60                  


Gly Ser Phe Arg Gln Leu Leu Gln Thr Ile Phe Tyr Gly Val Thr Cys 
65                  70                  75                  80  


Leu Asp Asp Val Leu Lys Arg Thr Lys Gly Gly Lys Asp Ile Lys Phe 
                85                  90                  95      


Leu Thr Ala Phe Arg Asp Leu Leu Phe Thr Thr Leu Ala Phe Pro Val 
            100                 105                 110         


Ser Thr Phe Val Phe Leu Ala Phe Trp Ile Leu Phe Leu Tyr Asn Arg 
        115                 120                 125             


Asp Leu Ile Tyr Pro Lys Val Leu Asp Thr Val Ile Pro Val Trp Leu 
    130                 135                 140                 


Asn His Ala Met His Thr Phe Ile Phe Pro Ile Thr Leu Ala Glu Val 
145                 150                 155                 160 


Val Leu Arg Pro His Ser Tyr Pro Ser Lys Lys Thr Gly Leu Thr Leu 
                165                 170                 175     


Leu Ala Ala Ala Ser Ile Ala Tyr Ile Ser Arg Ile Leu Trp Leu Tyr 
            180                 185                 190         


Phe Glu Thr Gly Thr Trp Val Tyr Pro Val Phe Ala Lys Leu Ser Leu 
        195                 200                 205             


Leu Gly Leu Ala Ala Phe Phe Ser Leu Ser Tyr Val Phe Ile Ala Ser 
    210                 215                 220                 


Ile Tyr Leu Leu Gly Glu Lys Leu Asn His Trp Lys Trp Gly Asp Met 
225                 230                 235                 240 


Arg Gln Pro Arg Lys Lys Arg Lys 
                245             


<210>  1739
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  1739

Met Val Phe Ser Ala Val Leu Thr Ala Phe His Thr Gly Thr Ser Asn 
1               5                   10                  15      


Thr Thr Phe Val Val Tyr Glu Asn Thr Tyr Met Asn Ile Thr Leu Pro 
            20                  25                  30          


Pro Pro Phe Gln His Pro Asp Leu Ser Pro Leu Leu Arg Tyr Ser Phe 
        35                  40                  45              


Glu Thr Met Ala Pro Thr Gly Leu Ser Ser Leu Thr Val Asn Ser Thr 
    50                  55                  60                  


Ala Val Pro Thr Thr Pro Ala Ala Phe Lys Ser Leu Asn Leu Pro Leu 
65                  70                  75                  80  


Gln Ile Thr Leu Ser Ala Ile Met Ile Phe Ile Leu Phe Val Ser Phe 
                85                  90                  95      


Leu Gly Asn Leu Val Val Cys Leu Met Val Tyr Gln Lys Ala Ala Met 
            100                 105                 110         


Arg Ser Ala Ile Asn Ile Leu Leu Ala Ser Leu Ala Phe Ala Asp Met 
        115                 120                 125             


Leu Leu Ala Val Leu Asn Met Pro Phe Ala Leu Val Thr Ile Leu Thr 
    130                 135                 140                 


Thr Arg Trp Ile Phe Gly Lys Phe Phe Cys Arg Val Ser Ala Met Phe 
145                 150                 155                 160 


Phe Trp Leu Phe Val Ile Glu Gly Val Ala Ile Leu Leu Ile Ile Ser 
                165                 170                 175     


Ile Asp Arg Phe Leu Ile Ile Val Gln Arg Gln Asp Lys Leu Asn Pro 
            180                 185                 190         


Tyr Arg Ala Lys Val Leu Ile Ala Val Ser Trp Ala Thr Ser Phe Cys 
        195                 200                 205             


Val Ala Phe Pro Leu Ala Val Gly Asn Pro Asp Leu Gln Ile Pro Ser 
    210                 215                 220                 


Arg Ala Pro Gln Cys Val Phe Gly Tyr Thr Thr Asn Pro Gly Tyr Gln 
225                 230                 235                 240 


Ala Tyr Val Ile Leu Ile Ser Leu Ile Ser Phe Phe Ile Pro Phe Leu 
                245                 250                 255     


Val Ile Leu Tyr Ser Phe Met Gly Ile Leu Asn Thr Leu Arg His Asn 
            260                 265                 270         


Ala Leu Arg Ile His Ser Tyr Pro Glu Gly Ile Cys Leu Ser Gln Ala 
        275                 280                 285             


Ser Lys Leu Gly Leu Met Ser Leu Gln Arg Pro Phe Gln Met Ser Ile 
    290                 295                 300                 


Asp Met Gly Phe Lys Thr Arg Ala Phe Thr Thr Ile Leu Ile Leu Phe 
305                 310                 315                 320 


Ala Val Phe Ile Val Cys Trp Ala Pro Phe Thr Thr Tyr Ser Leu Val 
                325                 330                 335     


Ala Thr Phe Ser Lys His Phe Tyr Tyr Gln His Asn Phe Phe Glu Ile 
            340                 345                 350         


Ser Thr Trp Leu Leu Trp Leu Cys Tyr Leu Lys Ser Ala Leu Asn Pro 
        355                 360                 365             


Leu Ile Tyr Tyr Trp Arg Ile Lys Lys Phe His Asp Ala Cys Leu Asp 
    370                 375                 380                 


Met Met Pro Lys Ser Phe Lys Phe Leu Pro Gln Leu Pro Gly His Thr 
385                 390                 395                 400 


Lys Arg Arg Ile Arg Pro Ser Ala Val Tyr Val Cys Gly Glu His Arg 
                405                 410                 415     


Thr Val Val 
            


<210>  1740
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  1740

Met Ala Met Asn Tyr Asn Ala Lys Asp Glu Val Asp Gly Gly Pro Pro 
1               5                   10                  15      


Cys Ala Pro Gly Gly Thr Ala Lys Thr Arg Arg Pro Asp Asn Thr Ala 
            20                  25                  30          


Phe Lys Gln Gln Arg Leu Pro Ala Trp Gln Pro Ile Leu Thr Ala Gly 
        35                  40                  45              


Thr Val Leu Pro Ile Phe Phe Ile Ile Gly Leu Ile Phe Ile Pro Ile 
    50                  55                  60                  


Gly Ile Gly Ile Phe Val Thr Ser Asn Asn Ile Arg Glu Ile Glu Gly 
65                  70                  75                  80  


Asn Val Phe Met Tyr Tyr Gly Leu Ser Asn Phe Tyr Gln Asn His Arg 
                85                  90                  95      


Arg Tyr Val Lys Ser Arg Asp Asp Ser Gln Leu Asn Gly Asp Ser Ser 
            100                 105                 110         


Ala Leu Leu Asn Pro Ser Lys Glu Cys Glu Pro Tyr Arg Arg Asn Glu 
        115                 120                 125             


Asp Lys Pro Ile Ala Pro Cys Gly Ala Ile Ala Asn Ser Met Phe Asn 
    130                 135                 140                 


Asp Thr Leu Glu Leu Phe Leu Ile Gly Asn Asp Ser Tyr Pro Ile Pro 
145                 150                 155                 160 


Ile Ala Leu Lys Lys Lys Gly Ile Ala Trp Trp Thr Asp Lys Asn Val 
                165                 170                 175     


Lys Phe Arg Asn Pro Pro Gly Gly Asp Asn Leu Glu Glu Arg Phe Lys 
            180                 185                 190         


Gly Thr Thr Lys Pro Val Asn Trp Leu Lys Pro Val Tyr Met Leu Asp 
        195                 200                 205             


Ser Asp Pro Asp Asn Asn Gly Phe Ile Asn Glu Asp Phe Ile Val Trp 
    210                 215                 220                 


Met Arg Thr Ala Ala Leu Pro Thr Phe Arg Lys Leu Tyr Arg Leu Ile 
225                 230                 235                 240 


Glu Arg Lys Ser Asp Leu His Pro Thr Leu Pro Ala Gly Arg Tyr Ser 
                245                 250                 255     


Leu Asn Val Thr Tyr Asn Tyr Pro Val His Tyr Phe Asp Gly Arg Lys 
            260                 265                 270         


Arg Met Ile Leu Ser Thr Ile Ser Trp Met Gly Gly Lys Asn Pro Phe 
        275                 280                 285             


Leu Gly Ile Ala Tyr Ile Ala Val Gly Ser Ile Ser Phe Leu Leu Gly 
    290                 295                 300                 


Val Val Leu Leu Val Ile Asn His Lys Tyr Arg Asn Ser Ser Asn Thr 
305                 310                 315                 320 


Ala Asp Ile Thr Ile 
                325 


<210>  1741
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  1741

Met Ser Leu Leu Ala Lys Pro Met Ser Phe Glu Thr Thr Ala Ile Thr 
1               5                   10                  15      


Phe Phe Ile Ile Leu Leu Ile Cys Leu Ile Cys Ile Leu Leu Leu Leu 
            20                  25                  30          


Val Val Phe Leu Tyr Lys Cys Phe Gln Gly Arg Lys Gly Lys Glu Thr 
        35                  40                  45              


Lys Lys Val Pro Cys Thr Asp Ala Asn Gly Gly Val Asp Cys Ala Ala 
    50                  55                  60                  


Ala Lys Val Val Thr Ser Asn Pro Glu Asp His Glu Arg Ile Leu Met 
65                  70                  75                  80  


Gln Val Met Asn Leu Asn Val Pro Met Arg Pro Gly Ile Leu Val Gln 
                85                  90                  95      


Arg Gln Ser Lys Glu Val Leu Ala Thr Pro Leu Glu Asn Arg Arg Asp 
            100                 105                 110         


Met Glu Ala Glu Glu Glu Asn Gln Ile Asn Glu Lys Gln Glu Pro Glu 
        115                 120                 125             


Asn Ala Gly Glu Thr Gly Gln Glu Glu Asp Asp Gly Leu Gln Lys Ile 
    130                 135                 140                 


His Thr Ser Val Thr Arg Thr Pro Ser Val Val Glu Ser Gln Lys Arg 
145                 150                 155                 160 


Pro Leu Lys Gly Val Thr Phe Ser Arg Glu Val Ile Val Val Asp Leu 
                165                 170                 175     


Gly Asn Glu Tyr Pro Thr Pro Arg Ser Tyr Thr Arg Glu His Lys Glu 
            180                 185                 190         


Arg Lys 
        


<210>  1742
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  1742

Met Gln Val Met Asn Leu Asn Val Pro Met Arg Pro Gly Ile Leu Val 
1               5                   10                  15      


Gln Arg Gln Ser Lys Glu Val Leu Ala Thr Pro Leu Glu Asn Arg Arg 
            20                  25                  30          


Asp Met Glu Ala Glu Glu Glu Asn Gln Ile Asn Glu Lys Gln Glu Pro 
        35                  40                  45              


Glu Asn Ala Gly Glu Thr Gly Gln Glu Glu Asp Asp Gly Leu Gln Lys 
    50                  55                  60                  


Ile His Thr Ser Val Thr Arg Thr Pro Ser Val Val Glu Ser Gln Lys 
65                  70                  75                  80  


Arg Pro Leu Lys Gly Val Thr Phe Ser Arg Glu Val Ile Val Val Asp 
                85                  90                  95      


Leu Gly Asn Glu Tyr Pro Thr Pro Arg Ser Tyr Thr Arg Glu His Lys 
            100                 105                 110         


Glu Arg Lys 
        115 


<210>  1743
<211>  1248
<212>  PRT
<213>  Homo sapiens

<400>  1743

Met Val Val Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro 
1               5                   10                  15      


Cys Leu Leu Ile Gln Ile Pro Glu Glu Leu Met Glu Pro Pro Val Ile 
            20                  25                  30          


Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe Pro Thr Asp Asp Ile 
        35                  40                  45              


Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu Val Gln Phe Arg Trp 
    50                  55                  60                  


Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu Glu Leu Gly Val Thr 
65                  70                  75                  80  


Val Tyr Gln Ser Pro His Ser Gly Ser Phe Thr Ile Thr Gly Asn Asn 
                85                  90                  95      


Ser Asn Phe Ala Gln Arg Phe Gln Gly Ile Tyr Arg Cys Phe Ala Ser 
            100                 105                 110         


Asn Lys Leu Gly Thr Ala Met Ser His Glu Ile Arg Leu Met Ala Glu 
        115                 120                 125             


Gly Ala Pro Lys Trp Pro Lys Glu Thr Val Lys Pro Val Glu Val Glu 
    130                 135                 140                 


Glu Gly Glu Ser Val Val Leu Pro Cys Asn Pro Pro Pro Ser Ala Glu 
145                 150                 155                 160 


Pro Leu Arg Ile Tyr Trp Met Asn Ser Lys Ile Leu His Ile Lys Gln 
                165                 170                 175     


Asp Glu Arg Val Thr Met Gly Gln Asn Gly Asn Leu Tyr Phe Ala Asn 
            180                 185                 190         


Val Leu Thr Ser Asp Asn His Ser Asp Tyr Ile Cys His Ala His Phe 
        195                 200                 205             


Pro Gly Thr Arg Thr Ile Ile Gln Lys Glu Pro Ile Asp Leu Arg Val 
    210                 215                 220                 


Lys Ala Thr Asn Ser Met Ile Asp Arg Lys Pro Arg Leu Leu Phe Pro 
225                 230                 235                 240 


Thr Asn Ser Ser Ser His Leu Val Ala Leu Gln Gly Gln Pro Leu Val 
                245                 250                 255     


Leu Glu Cys Ile Ala Glu Gly Phe Pro Thr Pro Thr Ile Lys Trp Leu 
            260                 265                 270         


Arg Pro Ser Gly Pro Met Pro Ala Asp Arg Val Thr Tyr Gln Asn His 
        275                 280                 285             


Asn Lys Thr Leu Gln Leu Leu Lys Val Gly Glu Glu Asp Asp Gly Glu 
    290                 295                 300                 


Tyr Arg Cys Leu Ala Glu Asn Ser Leu Gly Ser Ala Arg His Ala Tyr 
305                 310                 315                 320 


Tyr Val Thr Val Glu Ala Ala Pro Tyr Trp Leu His Lys Pro Gln Ser 
                325                 330                 335     


His Leu Tyr Gly Pro Gly Glu Thr Ala Arg Leu Asp Cys Gln Val Gln 
            340                 345                 350         


Gly Arg Pro Gln Pro Glu Val Thr Trp Arg Ile Asn Gly Ile Pro Val 
        355                 360                 365             


Glu Glu Leu Ala Lys Asp Gln Lys Tyr Arg Ile Gln Arg Gly Ala Leu 
    370                 375                 380                 


Ile Leu Ser Asn Val Gln Pro Ser Asp Thr Met Val Thr Gln Cys Glu 
385                 390                 395                 400 


Ala Arg Asn Arg His Gly Leu Leu Leu Ala Asn Ala Tyr Ile Tyr Val 
                405                 410                 415     


Val Gln Leu Pro Ala Lys Ile Leu Thr Ala Asp Asn Gln Thr Tyr Met 
            420                 425                 430         


Ala Val Gln Gly Ser Thr Ala Tyr Leu Leu Cys Lys Ala Phe Gly Ala 
        435                 440                 445             


Pro Val Pro Ser Val Gln Trp Leu Asp Glu Asp Gly Thr Thr Val Leu 
    450                 455                 460                 


Gln Asp Glu Arg Phe Phe Pro Tyr Ala Asn Gly Thr Leu Gly Ile Arg 
465                 470                 475                 480 


Asp Leu Gln Ala Asn Asp Thr Gly Arg Tyr Phe Cys Leu Ala Ala Asn 
                485                 490                 495     


Asp Gln Asn Asn Val Thr Ile Met Ala Asn Leu Lys Val Lys Asp Ala 
            500                 505                 510         


Thr Gln Ile Thr Gln Gly Pro Arg Ser Thr Ile Glu Lys Lys Gly Ser 
        515                 520                 525             


Arg Val Thr Phe Thr Cys Gln Ala Ser Phe Asp Pro Ser Leu Gln Pro 
    530                 535                 540                 


Ser Ile Thr Trp Arg Gly Asp Gly Arg Asp Leu Gln Glu Leu Gly Asp 
545                 550                 555                 560 


Ser Asp Lys Tyr Phe Ile Glu Asp Gly Arg Leu Val Ile His Ser Leu 
                565                 570                 575     


Asp Tyr Ser Asp Gln Gly Asn Tyr Ser Cys Val Ala Ser Thr Glu Leu 
            580                 585                 590         


Asp Val Val Glu Ser Arg Ala Gln Leu Leu Val Val Gly Ser Pro Gly 
        595                 600                 605             


Pro Val Pro Arg Leu Val Leu Ser Asp Leu His Leu Leu Thr Gln Ser 
    610                 615                 620                 


Gln Val Arg Val Ser Trp Ser Pro Ala Glu Asp His Asn Ala Pro Ile 
625                 630                 635                 640 


Glu Lys Tyr Asp Ile Glu Phe Glu Asp Lys Glu Met Ala Pro Glu Lys 
                645                 650                 655     


Trp Tyr Ser Leu Gly Lys Val Pro Gly Asn Gln Thr Ser Thr Thr Leu 
            660                 665                 670         


Lys Leu Ser Pro Tyr Val His Tyr Thr Phe Arg Val Thr Ala Ile Asn 
        675                 680                 685             


Lys Tyr Gly Pro Gly Glu Pro Ser Pro Val Ser Glu Thr Val Val Thr 
    690                 695                 700                 


Pro Glu Ala Ala Pro Glu Lys Asn Pro Val Asp Val Lys Gly Glu Gly 
705                 710                 715                 720 


Asn Glu Thr Thr Asn Met Val Ile Thr Trp Lys Pro Leu Arg Trp Met 
                725                 730                 735     


Asp Trp Asn Ala Pro Gln Val Gln Tyr Arg Val Gln Trp Arg Pro Gln 
            740                 745                 750         


Gly Thr Arg Gly Pro Trp Gln Glu Gln Ile Val Ser Asp Pro Phe Leu 
        755                 760                 765             


Val Val Ser Asn Thr Ser Thr Phe Val Pro Tyr Glu Ile Lys Val Gln 
    770                 775                 780                 


Ala Val Asn Ser Gln Gly Lys Gly Pro Glu Pro Gln Val Thr Ile Gly 
785                 790                 795                 800 


Tyr Ser Gly Glu Asp Tyr Pro Gln Ala Ile Pro Glu Leu Glu Gly Ile 
                805                 810                 815     


Glu Ile Leu Asn Ser Ser Ala Val Leu Val Lys Trp Arg Pro Val Asp 
            820                 825                 830         


Leu Ala Gln Val Lys Gly His Leu Arg Gly Tyr Asn Val Thr Tyr Trp 
        835                 840                 845             


Arg Glu Gly Ser Gln Arg Lys His Ser Lys Arg His Ile His Lys Asp 
    850                 855                 860                 


His Val Val Val Pro Ala Asn Thr Thr Ser Val Ile Leu Ser Gly Leu 
865                 870                 875                 880 


Arg Pro Tyr Ser Ser Tyr His Leu Glu Val Gln Ala Phe Asn Gly Arg 
                885                 890                 895     


Gly Ser Gly Pro Ala Ser Glu Phe Thr Phe Ser Thr Pro Glu Gly Val 
            900                 905                 910         


Pro Gly His Pro Glu Ala Leu His Leu Glu Cys Gln Ser Asn Thr Ser 
        915                 920                 925             


Leu Leu Leu Arg Trp Gln Pro Pro Leu Ser His Asn Gly Val Leu Thr 
    930                 935                 940                 


Gly Tyr Val Leu Ser Tyr His Pro Leu Asp Glu Gly Gly Lys Gly Gln 
945                 950                 955                 960 


Leu Ser Phe Asn Leu Arg Asp Pro Glu Leu Arg Thr His Asn Leu Thr 
                965                 970                 975     


Asp Leu Ser Pro His Leu Arg Tyr Arg Phe Gln Leu Gln Ala Thr Thr 
            980                 985                 990         


Lys Glu Gly Pro Gly Glu Ala Ile  Val Arg Glu Gly Gly  Thr Met Ala 
        995                 1000                 1005             


Leu Ser  Gly Ile Ser Asp Phe  Gly Asn Ile Ser Ala  Thr Ala Gly 
    1010                 1015                 1020             


Glu Asn  Tyr Ser Val Val Ser  Trp Val Pro Lys Glu  Gly Gln Cys 
    1025                 1030                 1035             


Asn Phe  Arg Phe His Ile Leu  Phe Lys Ala Leu Gly  Glu Glu Lys 
    1040                 1045                 1050             


Gly Gly  Ala Ser Leu Ser Pro  Gln Tyr Val Ser Tyr  Asn Gln Ser 
    1055                 1060                 1065             


Ser Tyr  Thr Gln Trp Asp Leu  Gln Pro Asp Thr Asp  Tyr Glu Ile 
    1070                 1075                 1080             


His Leu  Phe Lys Glu Arg Met  Phe Arg His Gln Met  Ala Val Lys 
    1085                 1090                 1095             


Thr Asn  Gly Thr Gly Arg Val  Arg Leu Pro Pro Ala  Gly Phe Ala 
    1100                 1105                 1110             


Thr Glu  Gly Trp Phe Ile Gly  Phe Val Ser Ala Ile  Ile Leu Leu 
    1115                 1120                 1125             


Leu Leu  Val Leu Leu Ile Leu  Cys Phe Ile Lys Arg  Ser Lys Gly 
    1130                 1135                 1140             


Gly Lys  Tyr Ser Val Lys Asp  Lys Glu Asp Thr Gln  Val Asp Ser 
    1145                 1150                 1155             


Glu Ala  Arg Pro Met Lys Asp  Glu Thr Phe Gly Glu  Tyr Ser Asp 
    1160                 1165                 1170             


Asn Glu  Glu Lys Ala Phe Gly  Ser Ser Gln Pro Ser  Leu Asn Gly 
    1175                 1180                 1185             


Asp Ile  Lys Pro Leu Gly Ser  Asp Asp Ser Leu Ala  Asp Tyr Gly 
    1190                 1195                 1200             


Gly Ser  Val Asp Val Gln Phe  Asn Glu Asp Gly Ser  Phe Ile Gly 
    1205                 1210                 1215             


Gln Tyr  Ser Gly Lys Lys Glu  Lys Glu Ala Ala Gly  Gly Asn Asp 
    1220                 1225                 1230             


Ser Ser  Gly Ala Thr Ser Pro  Ile Asn Pro Ala Val  Ala Leu Glu 
    1235                 1240                 1245             


<210>  1744
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  1744

Met Thr Glu Asp Ser Gln Arg Asn Phe Arg Ser Val Tyr Tyr Glu Lys 
1               5                   10                  15      


Val Gly Phe Arg Gly Val Glu Glu Lys Lys Ser Leu Glu Ile Leu Leu 
            20                  25                  30          


Lys Asp Asp Arg Leu Asp Thr Glu Lys Leu Cys Thr Phe Ser Gln Arg 
        35                  40                  45              


Phe Pro Leu Pro Ser Met Tyr Arg Ala Leu Val Trp Lys Val Leu Leu 
    50                  55                  60                  


Gly Ile Leu Pro Pro His His Glu Ser His Ala Lys Val Met Met Tyr 
65                  70                  75                  80  


Arg Lys Glu Gln Tyr Leu Asp Val Leu His Ala Leu Lys Val Val Arg 
                85                  90                  95      


Phe Val Ser Asp Ala Thr Pro Gln Ala Glu Val Tyr Leu Arg Met Tyr 
            100                 105                 110         


Gln Leu Glu Ser Gly Lys Leu Pro Arg Ser Pro Ser Phe Pro Leu Glu 
        115                 120                 125             


Pro Asp Asp Glu Val Phe Leu Ala Ile Ala Lys Ala Met Glu Glu Met 
    130                 135                 140                 


Val Glu Asp Ser Val Asp Cys Tyr Trp Ile Thr Arg Arg Phe Val Asn 
145                 150                 155                 160 


Gln Leu Asn Thr Lys Tyr Arg Asp Ser Leu Pro Gln Leu Pro Lys Ala 
                165                 170                 175     


Phe Glu Gln Tyr Leu Asn Leu Glu Asp Gly Arg Leu Leu Thr His Leu 
            180                 185                 190         


Arg Met Cys Ser Ala Ala Pro Lys Leu Pro Tyr Asp Leu Trp Phe Lys 
        195                 200                 205             


Arg Cys Phe Ala Gly Cys Leu Pro Glu Ser Ser Leu Gln Arg Val Trp 
    210                 215                 220                 


Asp Lys Val Val Ser Gly Ser Cys Lys Ile Leu Val Phe Val Ala Val 
225                 230                 235                 240 


Glu Ile Leu Leu Thr Phe Lys Ile Lys Val Met Ala Leu Asn Ser Ala 
                245                 250                 255     


Glu Lys Ile Thr Lys Phe Leu Glu Asn Ile Pro Gln Asp Ser Ser Asp 
            260                 265                 270         


Ala Ile Val Ser Lys Ala Ile Asp Leu Trp His Lys His Cys Gly Thr 
        275                 280                 285             


Pro Val His Ser Ser 
    290             


<210>  1745
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  1745

Met Thr Glu Asp Ser Gln Arg Asn Phe Arg Ser Val Tyr Tyr Glu Lys 
1               5                   10                  15      


Val Gly Phe Arg Gly Val Glu Glu Lys Lys Ser Leu Glu Ile Leu Leu 
            20                  25                  30          


Lys Asp Asp Arg Leu Asp Thr Glu Lys Leu Cys Thr Phe Ser Gln Arg 
        35                  40                  45              


Phe Pro Leu Pro Ser Met Tyr Arg Ala Leu Val Trp Lys Val Leu Leu 
    50                  55                  60                  


Gly Ile Leu Pro Pro His His Glu Ser His Ala Lys Val Met Met Tyr 
65                  70                  75                  80  


Arg Lys Glu Gln Tyr Leu Asp Val Leu His Ala Leu Lys Val Val Arg 
                85                  90                  95      


Phe Val Ser Asp Ala Thr Pro Gln Ala Glu Val Tyr Leu Arg Met Tyr 
            100                 105                 110         


Gln Leu Glu Ser Gly Lys Leu Pro Arg Ser Pro Ser Phe Pro Leu Glu 
        115                 120                 125             


Pro Asp Asp Glu Val Phe Leu Ala Ile Ala Lys Ala Met Glu Glu Met 
    130                 135                 140                 


Val Glu Asp Ser Val Asp Cys Tyr Trp Ile Thr Arg Arg Phe Val Asn 
145                 150                 155                 160 


Gln Leu Asn Thr Lys Tyr Arg Asp Ser Leu Pro Gln Leu Pro Lys Ala 
                165                 170                 175     


Phe Glu Gln Tyr Leu Asn Leu Glu Asp Gly Arg Leu Leu Thr His Leu 
            180                 185                 190         


Arg Met Cys Ser Ala Ala Pro Lys Leu Pro Tyr Asp Leu Trp Phe Lys 
        195                 200                 205             


Arg Cys Phe Ala Gly Cys Leu Pro Glu Ser Ser Leu Gln Arg Val Trp 
    210                 215                 220                 


Asp Lys Val Val Ser Gly Ser Cys Lys Ile Leu Val Phe Val Ala Val 
225                 230                 235                 240 


Glu Ile Leu Leu Thr Phe Lys Ile Lys Val Met Ala Leu Asn Ser Ala 
                245                 250                 255     


Glu Lys Ile Thr Lys Phe Leu Glu Asn Ile Pro Gln Asp Ser Ser Asp 
            260                 265                 270         


Ala Ile Val Ser Lys Ala Ile Asp Leu Trp His Lys His Cys Gly Thr 
        275                 280                 285             


Pro Val His Ser Ser 
    290             


<210>  1746
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  1746

Met Thr Glu Asp Ser Gln Arg Asn Phe Arg Ser Val Tyr Tyr Glu Lys 
1               5                   10                  15      


Val Gly Phe Arg Gly Val Glu Glu Lys Lys Ser Leu Glu Ile Leu Leu 
            20                  25                  30          


Lys Asp Asp Arg Leu Gly Ile Leu Pro Pro His His Glu Ser His Ala 
        35                  40                  45              


Lys Val Met Met Tyr Arg Lys Glu Gln Tyr Leu Asp Val Leu His Ala 
    50                  55                  60                  


Leu Lys Val Val Arg Phe Val Ser Asp Ala Thr Pro Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Leu Arg Met Tyr Gln Leu Glu Ser Gly Lys Leu Pro Arg Ser Pro 
                85                  90                  95      


Ser Phe Pro Leu Glu Pro Asp Asp Glu Val Phe Leu Ala Ile Ala Lys 
            100                 105                 110         


Ala Met Glu Glu Met Val Glu Asp Ser Val Asp Cys Tyr Trp Ile Thr 
        115                 120                 125             


Arg Arg Phe Val Asn Gln Leu Asn Thr Lys Tyr Arg Asp Ser Leu Pro 
    130                 135                 140                 


Gln Leu Pro Lys Ala Phe Glu Gln Tyr Leu Asn Leu Glu Asp Gly Arg 
145                 150                 155                 160 


Leu Leu Thr His Leu Arg Met Cys Ser Ala Ala Pro Lys Leu Pro Tyr 
                165                 170                 175     


Asp Leu Trp Phe Lys Arg Cys Phe Ala Gly Cys Leu Pro Glu Ser Ser 
            180                 185                 190         


Leu Gln Arg Val Trp Asp Lys Val Val Ser Gly Ser Cys Lys Ile Leu 
        195                 200                 205             


Val Phe Val Ala Val Glu Ile Leu Leu Thr Phe Lys Ile Lys Val Met 
    210                 215                 220                 


Ala Leu Asn Ser Ala Glu Lys Ile Thr Lys Phe Leu Glu Asn Ile Pro 
225                 230                 235                 240 


Gln Asp Ser Ser Asp Ala Ile Val Ser Lys Ala Ile Asp Leu Trp His 
                245                 250                 255     


Lys His Cys Gly Thr Pro Val His Ser Ser 
            260                 265     


<210>  1747
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  1747

Met Asp Leu Ala Lys Ser Gly Ile Lys Ile Leu Val Pro Lys Ser Pro 
1               5                   10                  15      


Val Lys Ser Arg Thr Ala Val Asp Gly Phe Gln Ser Glu Ser Pro Glu 
            20                  25                  30          


Lys Leu Asp Pro Val Glu Gln Gly Gln Glu Asp Thr Val Ala Pro Glu 
        35                  40                  45              


Val Ala Ala Glu Lys Pro Val Gly Ala Leu Leu Gly Pro Gly Ala Glu 
    50                  55                  60                  


Arg Ala Arg Met Gly Ser Arg Pro Arg Ile His Pro Leu Val Pro Gln 
65                  70                  75                  80  


Val Pro Gly Pro Val Thr Ala Ala Met Ala Thr Gly Leu Ala Val Asn 
                85                  90                  95      


Gly Lys Gly Thr Ser Pro Phe Met Asp Ala Leu Thr Ala Asn Gly Thr 
            100                 105                 110         


Thr Asn Ile Gln Thr Ser Val Thr Gly Val Thr Ala Ser Lys Arg Lys 
        115                 120                 125             


Phe Ile Asp Asp Arg Arg Asp Gln Pro Phe Asp Lys Arg Leu Arg Phe 
    130                 135                 140                 


Ser Val Arg Gln Thr Glu Ser Ala Tyr Arg Tyr Arg Asp Ile Val Val 
145                 150                 155                 160 


Arg Lys Gln Asp Gly Phe Thr His Ile Leu Leu Ser Thr Lys Ser Ser 
                165                 170                 175     


Glu Asn Asn Ser Leu Asn Pro Glu Val Met Arg Glu Val Gln Ser Ala 
            180                 185                 190         


Leu Ser Thr Ala Ala Ala Asp Asp Ser Lys Leu Val Leu Leu Ser Ala 
        195                 200                 205             


Val Gly Ser Val Phe Cys Cys Gly Leu Asp Phe Ile Tyr Phe Ile Arg 
    210                 215                 220                 


Arg Leu Thr Asp Asp Arg Lys Arg Glu Ser Thr Lys Met Ala Glu Ala 
225                 230                 235                 240 


Ile Arg Asn Phe Val Asn Thr Phe Ile Gln Phe Lys Lys Pro Ile Ile 
                245                 250                 255     


Val Ala Val Asn Gly Pro Ala Ile Gly Leu Gly Ala Ser Ile Leu Pro 
            260                 265                 270         


Leu Cys Asp Val Val Trp Ala Asn Glu Lys Ala Trp Phe Gln Thr Pro 
        275                 280                 285             


Tyr Thr Thr Phe Gly Gln Ser Pro Asp Gly Cys Ser Thr Val Met Phe 
    290                 295                 300                 


Pro Lys Ile Met Gly Gly Ala Ser Ala Asn Glu Met Leu Leu Ser Gly 
305                 310                 315                 320 


Arg Lys Leu Thr Ala Gln Glu Ala Cys Gly Lys Gly Leu Val Ser Gln 
                325                 330                 335     


Val Phe Trp Pro Gly Thr Phe Thr Gln Glu Val Met Val Arg Ile Lys 
            340                 345                 350         


Glu Leu Ala Ser Cys Asn Pro Val Val Leu Glu Glu Ser Lys Ala Leu 
        355                 360                 365             


Val Arg Cys Asn Met Lys Met Glu Leu Glu Gln Ala Asn Glu Arg Glu 
    370                 375                 380                 


Cys Glu Val Leu Lys Lys Ile Trp Gly Ser Ala Gln Gly Met Asp Ser 
385                 390                 395                 400 


Met Leu Lys Tyr Leu Gln Arg Lys Ile Asp Glu Phe 
                405                 410         


<210>  1748
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  1748

Met Asp Leu Ala Lys Ser Gly Ile Lys Ile Leu Val Pro Lys Ser Pro 
1               5                   10                  15      


Val Lys Ser Arg Thr Ala Val Asp Gly Phe Gln Ser Glu Ser Pro Glu 
            20                  25                  30          


Lys Leu Asp Pro Val Glu Gln Gly Gln Glu Asp Thr Val Ala Pro Glu 
        35                  40                  45              


Val Ala Ala Glu Lys Pro Val Gly Ala Leu Leu Gly Pro Gly Ala Glu 
    50                  55                  60                  


Arg Ala Arg Met Gly Ser Arg Pro Arg Ile His Pro Leu Val Pro Gln 
65                  70                  75                  80  


Val Pro Gly Pro Val Thr Ala Ala Met Ala Thr Gly Leu Ala Val Asn 
                85                  90                  95      


Gly Lys Gly Thr Ser Pro Phe Met Asp Ala Leu Thr Ala Asn Gly Thr 
            100                 105                 110         


Thr Asn Ile Gln Thr Ser Val Thr Gly Val Thr Ala Ser Lys Arg Lys 
        115                 120                 125             


Phe Ile Asp Asp Arg Arg Asp Gln Pro Phe Asp Lys Arg Leu Arg Phe 
    130                 135                 140                 


Ser Val Arg Gln Thr Glu Ser Ala Tyr Arg Tyr Arg Asp Ile Val Val 
145                 150                 155                 160 


Arg Lys Gln Asp Gly Phe Thr His Ile Leu Leu Ser Thr Lys Ser Ser 
                165                 170                 175     


Glu Asn Asn Ser Leu Asn Pro Glu Val Met Arg Glu Val Gln Ser Ala 
            180                 185                 190         


Leu Ser Thr Ala Ala Ala Asp Asp Ser Lys Leu Val Leu Leu Ser Ala 
        195                 200                 205             


Val Gly Ser Val Phe Cys Cys Gly Leu Asp Phe Ile Tyr Phe Ile Arg 
    210                 215                 220                 


Arg Leu Thr Asp Asp Arg Lys Arg Glu Ser Thr Lys Met Ala Glu Ala 
225                 230                 235                 240 


Ile Arg Asn Phe Val Asn Thr Phe Ile Gln Phe Lys Lys Pro Ile Ile 
                245                 250                 255     


Val Ala Val Asn Gly Pro Ala Ile Gly Leu Gly Ala Ser Ile Leu Pro 
            260                 265                 270         


Leu Cys Asp Val Val Trp Ala Asn Glu Lys Ala Trp Phe Gln Thr Pro 
        275                 280                 285             


Tyr Thr Thr Phe Gly Gln Ser Pro Asp Gly Cys Ser Thr Val Met Phe 
    290                 295                 300                 


Pro Lys Ile Met Gly Gly Ala Ser Ala Asn Glu Met Leu Leu Ser Gly 
305                 310                 315                 320 


Arg Lys Leu Thr Ala Gln Glu Ala Cys Gly Lys Gly Leu Val Ser Gln 
                325                 330                 335     


Val Phe Trp Pro Gly Thr Phe Thr Gln Glu Val Met Val Arg Ile Lys 
            340                 345                 350         


Glu Leu Ala Ser Cys Asn Pro Val Val Leu Glu Glu Ser Lys Ala Leu 
        355                 360                 365             


Val Arg Cys Asn Met Lys Met Glu Leu Glu Gln Ala Asn Glu Arg Glu 
    370                 375                 380                 


Cys Glu Val Leu Lys Lys Ile Trp Gly Ser Ala Gln Gly Met Asp Ser 
385                 390                 395                 400 


Met Leu Lys Tyr Leu Gln Arg Lys Ile Asp Glu Phe 
                405                 410         


<210>  1749
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  1749

Met Arg Thr Pro Gln Leu Ala Leu Leu Gln Val Phe Phe Leu Val Phe 
1               5                   10                  15      


Pro Asp Gly Val Arg Pro Gln Pro Ser Ser Ser Pro Ser Gly Ala Val 
            20                  25                  30          


Pro Thr Ser Leu Glu Leu Gln Arg Gly Thr Asp Gly Gly Thr Leu Gln 
        35                  40                  45              


Ser Pro Ser Glu Ala Thr Ala Thr Arg Pro Ala Val Pro Gly Leu Pro 
    50                  55                  60                  


Thr Val Val Pro Thr Leu Val Thr Pro Ser Ala Pro Gly Asn Arg Thr 
65                  70                  75                  80  


Val Asp Leu Phe Pro Val Leu Pro Ile Cys Val Cys Asp Leu Thr Pro 
                85                  90                  95      


Gly Ala Cys Asp Ile Asn Cys Cys Cys Asp Arg Asp Cys Tyr Leu Leu 
            100                 105                 110         


His Pro Arg Thr Val Phe Ser Phe Cys Leu Pro Gly Ser Val Arg Ser 
        115                 120                 125             


Ser Ser Trp Val Cys Val Asp Asn Ser Val Ile Phe Arg Ser Asn Ser 
    130                 135                 140                 


Pro Phe Pro Ser Arg Val Phe Met Asp Ser Asn Gly Ile Arg Gln Phe 
145                 150                 155                 160 


Cys Val His Val Asn Asn Cys Phe Leu Glu Ser Lys Ser Thr Thr Cys 
                165                 170                 175     


Thr Arg Phe Phe Lys Asn Leu Ala Ser Ser Cys Thr Leu Asp Ser Ala 
            180                 185                 190         


Leu Asn Ala Ala Ser Tyr Tyr Asn Phe Thr Val Leu Lys Val Pro Arg 
        195                 200                 205             


Ser Met Thr Asp Pro Gln Asn Met Glu Ala Phe Gln Gln Ser Thr Ala 
    210                 215                 220                 


Ala Ser Leu Thr Ser Pro Arg Ser Gly Asn Pro Gly Tyr Ile Val Gly 
225                 230                 235                 240 


Lys Pro Leu Leu Ala Leu Thr Asp Asp Ile Ser Tyr Ser Met Thr Leu 
                245                 250                 255     


Leu Gln Ser Gln Gly Asn Gly Ser Cys Ser Val Lys Arg His Glu Val 
            260                 265                 270         


Gln Phe Gly Val Asn Ala Ile Ser Gly Cys Lys Leu Arg Leu Lys Lys 
        275                 280                 285             


Ala Asp Cys Ser His Leu Gln Gln Glu Ile Tyr Gln Thr Leu His Gly 
    290                 295                 300                 


Arg Pro Arg Pro Glu Tyr Val Ala Ile Phe Gly Asn Ala Asp Pro Ala 
305                 310                 315                 320 


Gln Lys Gly Gly Trp Thr Arg Ile Leu Asn Arg His Cys Ser Ile Ser 
                325                 330                 335     


Ala Ile Asn Cys Thr Ser Cys Cys Leu Ile Pro Val Ser Leu Glu Ile 
            340                 345                 350         


Gln Val Leu Trp Ala Tyr Val Gly Leu Leu Ser Asn Pro Gln Ala His 
        355                 360                 365             


Val Ser Gly Val Arg Phe Leu Tyr Gln Cys Gln Ser Ile Gln Asp Ser 
    370                 375                 380                 


Gln Gln Val Thr Glu Val Ser Leu Thr Thr Leu Val Asn Phe Val Asp 
385                 390                 395                 400 


Ile Thr Gln Lys Pro Gln Pro Pro Arg Gly Gln Pro Lys Met Asp Trp 
                405                 410                 415     


Lys Trp Pro Phe Asp Phe Phe Pro Phe Lys Val Ala Phe Ser Arg Gly 
            420                 425                 430         


Val Phe Ser Gln Lys Cys Ser Val Ser Pro Ile Leu Ile Leu Cys Leu 
        435                 440                 445             


Leu Leu Leu Gly Val Leu Asn Leu Glu Thr Met 
    450                 455                 


<210>  1750
<211>  845
<212>  PRT
<213>  Homo sapiens

<400>  1750

Met Leu Ser Gly Val Trp Phe Leu Ser Val Leu Thr Val Ala Gly Ile 
1               5                   10                  15      


Leu Gln Thr Glu Ser Arg Lys Thr Ala Lys Asp Ile Cys Lys Ile Arg 
            20                  25                  30          


Cys Leu Cys Glu Glu Lys Glu Asn Val Leu Asn Ile Asn Cys Glu Asn 
        35                  40                  45              


Lys Gly Phe Thr Thr Val Ser Leu Leu Gln Pro Pro Gln Tyr Arg Ile 
    50                  55                  60                  


Tyr Gln Leu Phe Leu Asn Gly Asn Leu Leu Thr Arg Leu Tyr Pro Asn 
65                  70                  75                  80  


Glu Phe Val Asn Tyr Ser Asn Ala Val Thr Leu His Leu Gly Asn Asn 
                85                  90                  95      


Gly Leu Gln Glu Ile Arg Thr Gly Ala Phe Ser Gly Leu Lys Thr Leu 
            100                 105                 110         


Lys Arg Leu His Leu Asn Asn Asn Lys Leu Glu Ile Leu Arg Glu Asp 
        115                 120                 125             


Thr Phe Leu Gly Leu Glu Ser Leu Glu Tyr Leu Gln Ala Asp Tyr Asn 
    130                 135                 140                 


Tyr Ile Ser Ala Ile Glu Ala Gly Ala Phe Ser Lys Leu Asn Lys Leu 
145                 150                 155                 160 


Lys Val Leu Ile Leu Asn Asp Asn Leu Leu Leu Ser Leu Pro Ser Asn 
                165                 170                 175     


Val Phe Arg Phe Val Leu Leu Thr His Leu Asp Leu Arg Gly Asn Arg 
            180                 185                 190         


Leu Lys Val Met Pro Phe Ala Gly Val Leu Glu His Ile Gly Gly Ile 
        195                 200                 205             


Met Glu Ile Gln Leu Glu Glu Asn Pro Trp Asn Cys Thr Cys Asp Leu 
    210                 215                 220                 


Leu Pro Leu Lys Ala Trp Leu Asp Thr Ile Thr Val Phe Val Gly Glu 
225                 230                 235                 240 


Ile Val Cys Glu Thr Pro Phe Arg Leu His Gly Lys Asp Val Thr Gln 
                245                 250                 255     


Leu Thr Arg Gln Asp Leu Cys Pro Arg Lys Ser Ala Ser Asp Ser Ser 
            260                 265                 270         


Gln Arg Gly Ser His Ala Asp Thr His Val Gln Arg Leu Ser Pro Thr 
        275                 280                 285             


Met Asn Pro Ala Leu Asn Pro Thr Arg Ala Pro Lys Ala Ser Arg Pro 
    290                 295                 300                 


Pro Lys Met Arg Asn Arg Pro Thr Pro Arg Val Thr Val Ser Lys Asp 
305                 310                 315                 320 


Arg Gln Ser Phe Gly Pro Ile Met Val Tyr Gln Thr Lys Ser Pro Val 
                325                 330                 335     


Pro Leu Thr Cys Pro Ser Ser Cys Val Cys Thr Ser Gln Ser Ser Asp 
            340                 345                 350         


Asn Gly Leu Asn Val Asn Cys Gln Glu Arg Lys Phe Thr Asn Ile Ser 
        355                 360                 365             


Asp Leu Gln Pro Lys Pro Thr Ser Pro Lys Lys Leu Tyr Leu Thr Gly 
    370                 375                 380                 


Asn Tyr Leu Gln Thr Val Tyr Lys Asn Asp Leu Leu Glu Tyr Ser Ser 
385                 390                 395                 400 


Leu Asp Leu Leu His Leu Gly Asn Asn Arg Ile Ala Val Ile Gln Glu 
                405                 410                 415     


Gly Ala Phe Thr Asn Leu Thr Ser Leu Arg Arg Leu Tyr Leu Asn Gly 
            420                 425                 430         


Asn Tyr Leu Glu Val Leu Tyr Pro Ser Met Phe Asp Gly Leu Gln Ser 
        435                 440                 445             


Leu Gln Tyr Leu Tyr Leu Glu Tyr Asn Val Ile Lys Glu Ile Lys Pro 
    450                 455                 460                 


Leu Thr Phe Asp Ala Leu Ile Asn Leu Gln Leu Leu Phe Leu Asn Asn 
465                 470                 475                 480 


Asn Leu Leu Arg Ser Leu Pro Asp Asn Ile Phe Gly Gly Thr Ala Leu 
                485                 490                 495     


Thr Arg Leu Asn Leu Arg Asn Asn His Phe Ser His Leu Pro Val Lys 
            500                 505                 510         


Gly Val Leu Asp Gln Leu Pro Ala Phe Ile Gln Ile Asp Leu Gln Glu 
        515                 520                 525             


Asn Pro Trp Asp Cys Thr Cys Asp Ile Met Gly Leu Lys Asp Trp Thr 
    530                 535                 540                 


Glu His Ala Asn Ser Pro Val Ile Ile Asn Glu Val Thr Cys Glu Ser 
545                 550                 555                 560 


Pro Ala Lys His Ala Gly Glu Ile Leu Lys Phe Leu Gly Arg Glu Ala 
                565                 570                 575     


Ile Cys Pro Asp Ser Pro Asn Leu Ser Asp Gly Thr Val Leu Ser Met 
            580                 585                 590         


Asn His Asn Thr Asp Thr Pro Arg Ser Leu Ser Val Ser Pro Ser Ser 
        595                 600                 605             


Tyr Pro Glu Leu His Thr Glu Val Pro Leu Ser Val Leu Ile Leu Gly 
    610                 615                 620                 


Leu Leu Val Val Phe Ile Leu Ser Val Cys Phe Gly Ala Gly Leu Phe 
625                 630                 635                 640 


Val Phe Val Leu Lys Arg Arg Lys Gly Val Pro Ser Val Pro Arg Asn 
                645                 650                 655     


Thr Asn Asn Leu Asp Val Ser Ser Phe Gln Leu Gln Tyr Gly Ser Tyr 
            660                 665                 670         


Asn Thr Glu Thr His Asp Lys Thr Asp Gly His Val Tyr Asn Tyr Ile 
        675                 680                 685             


Pro Pro Pro Val Gly Gln Met Cys Gln Asn Pro Ile Tyr Met Gln Lys 
    690                 695                 700                 


Glu Gly Asp Pro Val Ala Tyr Tyr Arg Asn Leu Gln Glu Phe Ser Tyr 
705                 710                 715                 720 


Ser Asn Leu Glu Glu Lys Lys Glu Glu Pro Ala Thr Pro Ala Tyr Thr 
                725                 730                 735     


Ile Ser Ala Thr Glu Leu Leu Glu Lys Gln Ala Thr Pro Arg Glu Pro 
            740                 745                 750         


Glu Leu Leu Tyr Gln Asn Ile Ala Glu Arg Val Lys Glu Leu Pro Ser 
        755                 760                 765             


Ala Gly Leu Val His Tyr Asn Phe Cys Thr Leu Pro Lys Arg Gln Phe 
    770                 775                 780                 


Ala Pro Ser Tyr Glu Ser Arg Arg Gln Asn Gln Asp Arg Ile Asn Lys 
785                 790                 795                 800 


Thr Val Leu Tyr Gly Thr Pro Arg Lys Cys Phe Val Gly Gln Ser Lys 
                805                 810                 815     


Pro Asn His Pro Leu Leu Gln Ala Lys Pro Gln Ser Glu Pro Asp Tyr 
            820                 825                 830         


Leu Glu Val Leu Glu Lys Gln Thr Ala Ile Ser Gln Leu 
        835                 840                 845 


<210>  1751
<211>  845
<212>  PRT
<213>  Homo sapiens

<400>  1751

Met Leu Ser Gly Val Trp Phe Leu Ser Val Leu Thr Val Ala Gly Ile 
1               5                   10                  15      


Leu Gln Thr Glu Ser Arg Lys Thr Ala Lys Asp Ile Cys Lys Ile Arg 
            20                  25                  30          


Cys Leu Cys Glu Glu Lys Glu Asn Val Leu Asn Ile Asn Cys Glu Asn 
        35                  40                  45              


Lys Gly Phe Thr Thr Val Ser Leu Leu Gln Pro Pro Gln Tyr Arg Ile 
    50                  55                  60                  


Tyr Gln Leu Phe Leu Asn Gly Asn Leu Leu Thr Arg Leu Tyr Pro Asn 
65                  70                  75                  80  


Glu Phe Val Asn Tyr Ser Asn Ala Val Thr Leu His Leu Gly Asn Asn 
                85                  90                  95      


Gly Leu Gln Glu Ile Arg Thr Gly Ala Phe Ser Gly Leu Lys Thr Leu 
            100                 105                 110         


Lys Arg Leu His Leu Asn Asn Asn Lys Leu Glu Ile Leu Arg Glu Asp 
        115                 120                 125             


Thr Phe Leu Gly Leu Glu Ser Leu Glu Tyr Leu Gln Ala Asp Tyr Asn 
    130                 135                 140                 


Tyr Ile Ser Ala Ile Glu Ala Gly Ala Phe Ser Lys Leu Asn Lys Leu 
145                 150                 155                 160 


Lys Val Leu Ile Leu Asn Asp Asn Leu Leu Leu Ser Leu Pro Ser Asn 
                165                 170                 175     


Val Phe Arg Phe Val Leu Leu Thr His Leu Asp Leu Arg Gly Asn Arg 
            180                 185                 190         


Leu Lys Val Met Pro Phe Ala Gly Val Leu Glu His Ile Gly Gly Ile 
        195                 200                 205             


Met Glu Ile Gln Leu Glu Glu Asn Pro Trp Asn Cys Thr Cys Asp Leu 
    210                 215                 220                 


Leu Pro Leu Lys Ala Trp Leu Asp Thr Ile Thr Val Phe Val Gly Glu 
225                 230                 235                 240 


Ile Val Cys Glu Thr Pro Phe Arg Leu His Gly Lys Asp Val Thr Gln 
                245                 250                 255     


Leu Thr Arg Gln Asp Leu Cys Pro Arg Lys Ser Ala Ser Asp Ser Ser 
            260                 265                 270         


Gln Arg Gly Ser His Ala Asp Thr His Val Gln Arg Leu Ser Pro Thr 
        275                 280                 285             


Met Asn Pro Ala Leu Asn Pro Thr Arg Ala Pro Lys Ala Ser Arg Pro 
    290                 295                 300                 


Pro Lys Met Arg Asn Arg Pro Thr Pro Arg Val Thr Val Ser Lys Asp 
305                 310                 315                 320 


Arg Gln Ser Phe Gly Pro Ile Met Val Tyr Gln Thr Lys Ser Pro Val 
                325                 330                 335     


Pro Leu Thr Cys Pro Ser Ser Cys Val Cys Thr Ser Gln Ser Ser Asp 
            340                 345                 350         


Asn Gly Leu Asn Val Asn Cys Gln Glu Arg Lys Phe Thr Asn Ile Ser 
        355                 360                 365             


Asp Leu Gln Pro Lys Pro Thr Ser Pro Lys Lys Leu Tyr Leu Thr Gly 
    370                 375                 380                 


Asn Tyr Leu Gln Thr Val Tyr Lys Asn Asp Leu Leu Glu Tyr Ser Ser 
385                 390                 395                 400 


Leu Asp Leu Leu His Leu Gly Asn Asn Arg Ile Ala Val Ile Gln Glu 
                405                 410                 415     


Gly Ala Phe Thr Asn Leu Thr Ser Leu Arg Arg Leu Tyr Leu Asn Gly 
            420                 425                 430         


Asn Tyr Leu Glu Val Leu Tyr Pro Ser Met Phe Asp Gly Leu Gln Ser 
        435                 440                 445             


Leu Gln Tyr Leu Tyr Leu Glu Tyr Asn Val Ile Lys Glu Ile Lys Pro 
    450                 455                 460                 


Leu Thr Phe Asp Ala Leu Ile Asn Leu Gln Leu Leu Phe Leu Asn Asn 
465                 470                 475                 480 


Asn Leu Leu Arg Ser Leu Pro Asp Asn Ile Phe Gly Gly Thr Ala Leu 
                485                 490                 495     


Thr Arg Leu Asn Leu Arg Asn Asn His Phe Ser His Leu Pro Val Lys 
            500                 505                 510         


Gly Val Leu Asp Gln Leu Pro Ala Phe Ile Gln Ile Asp Leu Gln Glu 
        515                 520                 525             


Asn Pro Trp Asp Cys Thr Cys Asp Ile Met Gly Leu Lys Asp Trp Thr 
    530                 535                 540                 


Glu His Ala Asn Ser Pro Val Ile Ile Asn Glu Val Thr Cys Glu Ser 
545                 550                 555                 560 


Pro Ala Lys His Ala Gly Glu Ile Leu Lys Phe Leu Gly Arg Glu Ala 
                565                 570                 575     


Ile Cys Pro Asp Ser Pro Asn Leu Ser Asp Gly Thr Val Leu Ser Met 
            580                 585                 590         


Asn His Asn Thr Asp Thr Pro Arg Ser Leu Ser Val Ser Pro Ser Ser 
        595                 600                 605             


Tyr Pro Glu Leu His Thr Glu Val Pro Leu Ser Val Leu Ile Leu Gly 
    610                 615                 620                 


Leu Leu Val Val Phe Ile Leu Ser Val Cys Phe Gly Ala Gly Leu Phe 
625                 630                 635                 640 


Val Phe Val Leu Lys Arg Arg Lys Gly Val Pro Ser Val Pro Arg Asn 
                645                 650                 655     


Thr Asn Asn Leu Asp Val Ser Ser Phe Gln Leu Gln Tyr Gly Ser Tyr 
            660                 665                 670         


Asn Thr Glu Thr His Asp Lys Thr Asp Gly His Val Tyr Asn Tyr Ile 
        675                 680                 685             


Pro Pro Pro Val Gly Gln Met Cys Gln Asn Pro Ile Tyr Met Gln Lys 
    690                 695                 700                 


Glu Gly Asp Pro Val Ala Tyr Tyr Arg Asn Leu Gln Glu Phe Ser Tyr 
705                 710                 715                 720 


Ser Asn Leu Glu Glu Lys Lys Glu Glu Pro Ala Thr Pro Ala Tyr Thr 
                725                 730                 735     


Ile Ser Ala Thr Glu Leu Leu Glu Lys Gln Ala Thr Pro Arg Glu Pro 
            740                 745                 750         


Glu Leu Leu Tyr Gln Asn Ile Ala Glu Arg Val Lys Glu Leu Pro Ser 
        755                 760                 765             


Ala Gly Leu Val His Tyr Asn Phe Cys Thr Leu Pro Lys Arg Gln Phe 
    770                 775                 780                 


Ala Pro Ser Tyr Glu Ser Arg Arg Gln Asn Gln Asp Arg Ile Asn Lys 
785                 790                 795                 800 


Thr Val Leu Tyr Gly Thr Pro Arg Lys Cys Phe Val Gly Gln Ser Lys 
                805                 810                 815     


Pro Asn His Pro Leu Leu Gln Ala Lys Pro Gln Ser Glu Pro Asp Tyr 
            820                 825                 830         


Leu Glu Val Leu Glu Lys Gln Thr Ala Ile Ser Gln Leu 
        835                 840                 845 


<210>  1752
<211>  845
<212>  PRT
<213>  Homo sapiens

<400>  1752

Met Leu Ser Gly Val Trp Phe Leu Ser Val Leu Thr Val Ala Gly Ile 
1               5                   10                  15      


Leu Gln Thr Glu Ser Arg Lys Thr Ala Lys Asp Ile Cys Lys Ile Arg 
            20                  25                  30          


Cys Leu Cys Glu Glu Lys Glu Asn Val Leu Asn Ile Asn Cys Glu Asn 
        35                  40                  45              


Lys Gly Phe Thr Thr Val Ser Leu Leu Gln Pro Pro Gln Tyr Arg Ile 
    50                  55                  60                  


Tyr Gln Leu Phe Leu Asn Gly Asn Leu Leu Thr Arg Leu Tyr Pro Asn 
65                  70                  75                  80  


Glu Phe Val Asn Tyr Ser Asn Ala Val Thr Leu His Leu Gly Asn Asn 
                85                  90                  95      


Gly Leu Gln Glu Ile Arg Thr Gly Ala Phe Ser Gly Leu Lys Thr Leu 
            100                 105                 110         


Lys Arg Leu His Leu Asn Asn Asn Lys Leu Glu Ile Leu Arg Glu Asp 
        115                 120                 125             


Thr Phe Leu Gly Leu Glu Ser Leu Glu Tyr Leu Gln Ala Asp Tyr Asn 
    130                 135                 140                 


Tyr Ile Ser Ala Ile Glu Ala Gly Ala Phe Ser Lys Leu Asn Lys Leu 
145                 150                 155                 160 


Lys Val Leu Ile Leu Asn Asp Asn Leu Leu Leu Ser Leu Pro Ser Asn 
                165                 170                 175     


Val Phe Arg Phe Val Leu Leu Thr His Leu Asp Leu Arg Gly Asn Arg 
            180                 185                 190         


Leu Lys Val Met Pro Phe Ala Gly Val Leu Glu His Ile Gly Gly Ile 
        195                 200                 205             


Met Glu Ile Gln Leu Glu Glu Asn Pro Trp Asn Cys Thr Cys Asp Leu 
    210                 215                 220                 


Leu Pro Leu Lys Ala Trp Leu Asp Thr Ile Thr Val Phe Val Gly Glu 
225                 230                 235                 240 


Ile Val Cys Glu Thr Pro Phe Arg Leu His Gly Lys Asp Val Thr Gln 
                245                 250                 255     


Leu Thr Arg Gln Asp Leu Cys Pro Arg Lys Ser Ala Ser Asp Ser Ser 
            260                 265                 270         


Gln Arg Gly Ser His Ala Asp Thr His Val Gln Arg Leu Ser Pro Thr 
        275                 280                 285             


Met Asn Pro Ala Leu Asn Pro Thr Arg Ala Pro Lys Ala Ser Arg Pro 
    290                 295                 300                 


Pro Lys Met Arg Asn Arg Pro Thr Pro Arg Val Thr Val Ser Lys Asp 
305                 310                 315                 320 


Arg Gln Ser Phe Gly Pro Ile Met Val Tyr Gln Thr Lys Ser Pro Val 
                325                 330                 335     


Pro Leu Thr Cys Pro Ser Ser Cys Val Cys Thr Ser Gln Ser Ser Asp 
            340                 345                 350         


Asn Gly Leu Asn Val Asn Cys Gln Glu Arg Lys Phe Thr Asn Ile Ser 
        355                 360                 365             


Asp Leu Gln Pro Lys Pro Thr Ser Pro Lys Lys Leu Tyr Leu Thr Gly 
    370                 375                 380                 


Asn Tyr Leu Gln Thr Val Tyr Lys Asn Asp Leu Leu Glu Tyr Ser Ser 
385                 390                 395                 400 


Leu Asp Leu Leu His Leu Gly Asn Asn Arg Ile Ala Val Ile Gln Glu 
                405                 410                 415     


Gly Ala Phe Thr Asn Leu Thr Ser Leu Arg Arg Leu Tyr Leu Asn Gly 
            420                 425                 430         


Asn Tyr Leu Glu Val Leu Tyr Pro Ser Met Phe Asp Gly Leu Gln Ser 
        435                 440                 445             


Leu Gln Tyr Leu Tyr Leu Glu Tyr Asn Val Ile Lys Glu Ile Lys Pro 
    450                 455                 460                 


Leu Thr Phe Asp Ala Leu Ile Asn Leu Gln Leu Leu Phe Leu Asn Asn 
465                 470                 475                 480 


Asn Leu Leu Arg Ser Leu Pro Asp Asn Ile Phe Gly Gly Thr Ala Leu 
                485                 490                 495     


Thr Arg Leu Asn Leu Arg Asn Asn His Phe Ser His Leu Pro Val Lys 
            500                 505                 510         


Gly Val Leu Asp Gln Leu Pro Ala Phe Ile Gln Ile Asp Leu Gln Glu 
        515                 520                 525             


Asn Pro Trp Asp Cys Thr Cys Asp Ile Met Gly Leu Lys Asp Trp Thr 
    530                 535                 540                 


Glu His Ala Asn Ser Pro Val Ile Ile Asn Glu Val Thr Cys Glu Ser 
545                 550                 555                 560 


Pro Ala Lys His Ala Gly Glu Ile Leu Lys Phe Leu Gly Arg Glu Ala 
                565                 570                 575     


Ile Cys Pro Asp Ser Pro Asn Leu Ser Asp Gly Thr Val Leu Ser Met 
            580                 585                 590         


Asn His Asn Thr Asp Thr Pro Arg Ser Leu Ser Val Ser Pro Ser Ser 
        595                 600                 605             


Tyr Pro Glu Leu His Thr Glu Val Pro Leu Ser Val Leu Ile Leu Gly 
    610                 615                 620                 


Leu Leu Val Val Phe Ile Leu Ser Val Cys Phe Gly Ala Gly Leu Phe 
625                 630                 635                 640 


Val Phe Val Leu Lys Arg Arg Lys Gly Val Pro Ser Val Pro Arg Asn 
                645                 650                 655     


Thr Asn Asn Leu Asp Val Ser Ser Phe Gln Leu Gln Tyr Gly Ser Tyr 
            660                 665                 670         


Asn Thr Glu Thr His Asp Lys Thr Asp Gly His Val Tyr Asn Tyr Ile 
        675                 680                 685             


Pro Pro Pro Val Gly Gln Met Cys Gln Asn Pro Ile Tyr Met Gln Lys 
    690                 695                 700                 


Glu Gly Asp Pro Val Ala Tyr Tyr Arg Asn Leu Gln Glu Phe Ser Tyr 
705                 710                 715                 720 


Ser Asn Leu Glu Glu Lys Lys Glu Glu Pro Ala Thr Pro Ala Tyr Thr 
                725                 730                 735     


Ile Ser Ala Thr Glu Leu Leu Glu Lys Gln Ala Thr Pro Arg Glu Pro 
            740                 745                 750         


Glu Leu Leu Tyr Gln Asn Ile Ala Glu Arg Val Lys Glu Leu Pro Ser 
        755                 760                 765             


Ala Gly Leu Val His Tyr Asn Phe Cys Thr Leu Pro Lys Arg Gln Phe 
    770                 775                 780                 


Ala Pro Ser Tyr Glu Ser Arg Arg Gln Asn Gln Asp Arg Ile Asn Lys 
785                 790                 795                 800 


Thr Val Leu Tyr Gly Thr Pro Arg Lys Cys Phe Val Gly Gln Ser Lys 
                805                 810                 815     


Pro Asn His Pro Leu Leu Gln Ala Lys Pro Gln Ser Glu Pro Asp Tyr 
            820                 825                 830         


Leu Glu Val Leu Glu Lys Gln Thr Ala Ile Ser Gln Leu 
        835                 840                 845 


<210>  1753
<211>  845
<212>  PRT
<213>  Homo sapiens

<400>  1753

Met Leu Ser Gly Val Trp Phe Leu Ser Val Leu Thr Val Ala Gly Ile 
1               5                   10                  15      


Leu Gln Thr Glu Ser Arg Lys Thr Ala Lys Asp Ile Cys Lys Ile Arg 
            20                  25                  30          


Cys Leu Cys Glu Glu Lys Glu Asn Val Leu Asn Ile Asn Cys Glu Asn 
        35                  40                  45              


Lys Gly Phe Thr Thr Val Ser Leu Leu Gln Pro Pro Gln Tyr Arg Ile 
    50                  55                  60                  


Tyr Gln Leu Phe Leu Asn Gly Asn Leu Leu Thr Arg Leu Tyr Pro Asn 
65                  70                  75                  80  


Glu Phe Val Asn Tyr Ser Asn Ala Val Thr Leu His Leu Gly Asn Asn 
                85                  90                  95      


Gly Leu Gln Glu Ile Arg Thr Gly Ala Phe Ser Gly Leu Lys Thr Leu 
            100                 105                 110         


Lys Arg Leu His Leu Asn Asn Asn Lys Leu Glu Ile Leu Arg Glu Asp 
        115                 120                 125             


Thr Phe Leu Gly Leu Glu Ser Leu Glu Tyr Leu Gln Ala Asp Tyr Asn 
    130                 135                 140                 


Tyr Ile Ser Ala Ile Glu Ala Gly Ala Phe Ser Lys Leu Asn Lys Leu 
145                 150                 155                 160 


Lys Val Leu Ile Leu Asn Asp Asn Leu Leu Leu Ser Leu Pro Ser Asn 
                165                 170                 175     


Val Phe Arg Phe Val Leu Leu Thr His Leu Asp Leu Arg Gly Asn Arg 
            180                 185                 190         


Leu Lys Val Met Pro Phe Ala Gly Val Leu Glu His Ile Gly Gly Ile 
        195                 200                 205             


Met Glu Ile Gln Leu Glu Glu Asn Pro Trp Asn Cys Thr Cys Asp Leu 
    210                 215                 220                 


Leu Pro Leu Lys Ala Trp Leu Asp Thr Ile Thr Val Phe Val Gly Glu 
225                 230                 235                 240 


Ile Val Cys Glu Thr Pro Phe Arg Leu His Gly Lys Asp Val Thr Gln 
                245                 250                 255     


Leu Thr Arg Gln Asp Leu Cys Pro Arg Lys Ser Ala Ser Asp Ser Ser 
            260                 265                 270         


Gln Arg Gly Ser His Ala Asp Thr His Val Gln Arg Leu Ser Pro Thr 
        275                 280                 285             


Met Asn Pro Ala Leu Asn Pro Thr Arg Ala Pro Lys Ala Ser Arg Pro 
    290                 295                 300                 


Pro Lys Met Arg Asn Arg Pro Thr Pro Arg Val Thr Val Ser Lys Asp 
305                 310                 315                 320 


Arg Gln Ser Phe Gly Pro Ile Met Val Tyr Gln Thr Lys Ser Pro Val 
                325                 330                 335     


Pro Leu Thr Cys Pro Ser Ser Cys Val Cys Thr Ser Gln Ser Ser Asp 
            340                 345                 350         


Asn Gly Leu Asn Val Asn Cys Gln Glu Arg Lys Phe Thr Asn Ile Ser 
        355                 360                 365             


Asp Leu Gln Pro Lys Pro Thr Ser Pro Lys Lys Leu Tyr Leu Thr Gly 
    370                 375                 380                 


Asn Tyr Leu Gln Thr Val Tyr Lys Asn Asp Leu Leu Glu Tyr Ser Ser 
385                 390                 395                 400 


Leu Asp Leu Leu His Leu Gly Asn Asn Arg Ile Ala Val Ile Gln Glu 
                405                 410                 415     


Gly Ala Phe Thr Asn Leu Thr Ser Leu Arg Arg Leu Tyr Leu Asn Gly 
            420                 425                 430         


Asn Tyr Leu Glu Val Leu Tyr Pro Ser Met Phe Asp Gly Leu Gln Ser 
        435                 440                 445             


Leu Gln Tyr Leu Tyr Leu Glu Tyr Asn Val Ile Lys Glu Ile Lys Pro 
    450                 455                 460                 


Leu Thr Phe Asp Ala Leu Ile Asn Leu Gln Leu Leu Phe Leu Asn Asn 
465                 470                 475                 480 


Asn Leu Leu Arg Ser Leu Pro Asp Asn Ile Phe Gly Gly Thr Ala Leu 
                485                 490                 495     


Thr Arg Leu Asn Leu Arg Asn Asn His Phe Ser His Leu Pro Val Lys 
            500                 505                 510         


Gly Val Leu Asp Gln Leu Pro Ala Phe Ile Gln Ile Asp Leu Gln Glu 
        515                 520                 525             


Asn Pro Trp Asp Cys Thr Cys Asp Ile Met Gly Leu Lys Asp Trp Thr 
    530                 535                 540                 


Glu His Ala Asn Ser Pro Val Ile Ile Asn Glu Val Thr Cys Glu Ser 
545                 550                 555                 560 


Pro Ala Lys His Ala Gly Glu Ile Leu Lys Phe Leu Gly Arg Glu Ala 
                565                 570                 575     


Ile Cys Pro Asp Ser Pro Asn Leu Ser Asp Gly Thr Val Leu Ser Met 
            580                 585                 590         


Asn His Asn Thr Asp Thr Pro Arg Ser Leu Ser Val Ser Pro Ser Ser 
        595                 600                 605             


Tyr Pro Glu Leu His Thr Glu Val Pro Leu Ser Val Leu Ile Leu Gly 
    610                 615                 620                 


Leu Leu Val Val Phe Ile Leu Ser Val Cys Phe Gly Ala Gly Leu Phe 
625                 630                 635                 640 


Val Phe Val Leu Lys Arg Arg Lys Gly Val Pro Ser Val Pro Arg Asn 
                645                 650                 655     


Thr Asn Asn Leu Asp Val Ser Ser Phe Gln Leu Gln Tyr Gly Ser Tyr 
            660                 665                 670         


Asn Thr Glu Thr His Asp Lys Thr Asp Gly His Val Tyr Asn Tyr Ile 
        675                 680                 685             


Pro Pro Pro Val Gly Gln Met Cys Gln Asn Pro Ile Tyr Met Gln Lys 
    690                 695                 700                 


Glu Gly Asp Pro Val Ala Tyr Tyr Arg Asn Leu Gln Glu Phe Ser Tyr 
705                 710                 715                 720 


Ser Asn Leu Glu Glu Lys Lys Glu Glu Pro Ala Thr Pro Ala Tyr Thr 
                725                 730                 735     


Ile Ser Ala Thr Glu Leu Leu Glu Lys Gln Ala Thr Pro Arg Glu Pro 
            740                 745                 750         


Glu Leu Leu Tyr Gln Asn Ile Ala Glu Arg Val Lys Glu Leu Pro Ser 
        755                 760                 765             


Ala Gly Leu Val His Tyr Asn Phe Cys Thr Leu Pro Lys Arg Gln Phe 
    770                 775                 780                 


Ala Pro Ser Tyr Glu Ser Arg Arg Gln Asn Gln Asp Arg Ile Asn Lys 
785                 790                 795                 800 


Thr Val Leu Tyr Gly Thr Pro Arg Lys Cys Phe Val Gly Gln Ser Lys 
                805                 810                 815     


Pro Asn His Pro Leu Leu Gln Ala Lys Pro Gln Ser Glu Pro Asp Tyr 
            820                 825                 830         


Leu Glu Val Leu Glu Lys Gln Thr Ala Ile Ser Gln Leu 
        835                 840                 845 


<210>  1754
<211>  845
<212>  PRT
<213>  Homo sapiens

<400>  1754

Met Leu Ser Gly Val Trp Phe Leu Ser Val Leu Thr Val Ala Gly Ile 
1               5                   10                  15      


Leu Gln Thr Glu Ser Arg Lys Thr Ala Lys Asp Ile Cys Lys Ile Arg 
            20                  25                  30          


Cys Leu Cys Glu Glu Lys Glu Asn Val Leu Asn Ile Asn Cys Glu Asn 
        35                  40                  45              


Lys Gly Phe Thr Thr Val Ser Leu Leu Gln Pro Pro Gln Tyr Arg Ile 
    50                  55                  60                  


Tyr Gln Leu Phe Leu Asn Gly Asn Leu Leu Thr Arg Leu Tyr Pro Asn 
65                  70                  75                  80  


Glu Phe Val Asn Tyr Ser Asn Ala Val Thr Leu His Leu Gly Asn Asn 
                85                  90                  95      


Gly Leu Gln Glu Ile Arg Thr Gly Ala Phe Ser Gly Leu Lys Thr Leu 
            100                 105                 110         


Lys Arg Leu His Leu Asn Asn Asn Lys Leu Glu Ile Leu Arg Glu Asp 
        115                 120                 125             


Thr Phe Leu Gly Leu Glu Ser Leu Glu Tyr Leu Gln Ala Asp Tyr Asn 
    130                 135                 140                 


Tyr Ile Ser Ala Ile Glu Ala Gly Ala Phe Ser Lys Leu Asn Lys Leu 
145                 150                 155                 160 


Lys Val Leu Ile Leu Asn Asp Asn Leu Leu Leu Ser Leu Pro Ser Asn 
                165                 170                 175     


Val Phe Arg Phe Val Leu Leu Thr His Leu Asp Leu Arg Gly Asn Arg 
            180                 185                 190         


Leu Lys Val Met Pro Phe Ala Gly Val Leu Glu His Ile Gly Gly Ile 
        195                 200                 205             


Met Glu Ile Gln Leu Glu Glu Asn Pro Trp Asn Cys Thr Cys Asp Leu 
    210                 215                 220                 


Leu Pro Leu Lys Ala Trp Leu Asp Thr Ile Thr Val Phe Val Gly Glu 
225                 230                 235                 240 


Ile Val Cys Glu Thr Pro Phe Arg Leu His Gly Lys Asp Val Thr Gln 
                245                 250                 255     


Leu Thr Arg Gln Asp Leu Cys Pro Arg Lys Ser Ala Ser Asp Ser Ser 
            260                 265                 270         


Gln Arg Gly Ser His Ala Asp Thr His Val Gln Arg Leu Ser Pro Thr 
        275                 280                 285             


Met Asn Pro Ala Leu Asn Pro Thr Arg Ala Pro Lys Ala Ser Arg Pro 
    290                 295                 300                 


Pro Lys Met Arg Asn Arg Pro Thr Pro Arg Val Thr Val Ser Lys Asp 
305                 310                 315                 320 


Arg Gln Ser Phe Gly Pro Ile Met Val Tyr Gln Thr Lys Ser Pro Val 
                325                 330                 335     


Pro Leu Thr Cys Pro Ser Ser Cys Val Cys Thr Ser Gln Ser Ser Asp 
            340                 345                 350         


Asn Gly Leu Asn Val Asn Cys Gln Glu Arg Lys Phe Thr Asn Ile Ser 
        355                 360                 365             


Asp Leu Gln Pro Lys Pro Thr Ser Pro Lys Lys Leu Tyr Leu Thr Gly 
    370                 375                 380                 


Asn Tyr Leu Gln Thr Val Tyr Lys Asn Asp Leu Leu Glu Tyr Ser Ser 
385                 390                 395                 400 


Leu Asp Leu Leu His Leu Gly Asn Asn Arg Ile Ala Val Ile Gln Glu 
                405                 410                 415     


Gly Ala Phe Thr Asn Leu Thr Ser Leu Arg Arg Leu Tyr Leu Asn Gly 
            420                 425                 430         


Asn Tyr Leu Glu Val Leu Tyr Pro Ser Met Phe Asp Gly Leu Gln Ser 
        435                 440                 445             


Leu Gln Tyr Leu Tyr Leu Glu Tyr Asn Val Ile Lys Glu Ile Lys Pro 
    450                 455                 460                 


Leu Thr Phe Asp Ala Leu Ile Asn Leu Gln Leu Leu Phe Leu Asn Asn 
465                 470                 475                 480 


Asn Leu Leu Arg Ser Leu Pro Asp Asn Ile Phe Gly Gly Thr Ala Leu 
                485                 490                 495     


Thr Arg Leu Asn Leu Arg Asn Asn His Phe Ser His Leu Pro Val Lys 
            500                 505                 510         


Gly Val Leu Asp Gln Leu Pro Ala Phe Ile Gln Ile Asp Leu Gln Glu 
        515                 520                 525             


Asn Pro Trp Asp Cys Thr Cys Asp Ile Met Gly Leu Lys Asp Trp Thr 
    530                 535                 540                 


Glu His Ala Asn Ser Pro Val Ile Ile Asn Glu Val Thr Cys Glu Ser 
545                 550                 555                 560 


Pro Ala Lys His Ala Gly Glu Ile Leu Lys Phe Leu Gly Arg Glu Ala 
                565                 570                 575     


Ile Cys Pro Asp Ser Pro Asn Leu Ser Asp Gly Thr Val Leu Ser Met 
            580                 585                 590         


Asn His Asn Thr Asp Thr Pro Arg Ser Leu Ser Val Ser Pro Ser Ser 
        595                 600                 605             


Tyr Pro Glu Leu His Thr Glu Val Pro Leu Ser Val Leu Ile Leu Gly 
    610                 615                 620                 


Leu Leu Val Val Phe Ile Leu Ser Val Cys Phe Gly Ala Gly Leu Phe 
625                 630                 635                 640 


Val Phe Val Leu Lys Arg Arg Lys Gly Val Pro Ser Val Pro Arg Asn 
                645                 650                 655     


Thr Asn Asn Leu Asp Val Ser Ser Phe Gln Leu Gln Tyr Gly Ser Tyr 
            660                 665                 670         


Asn Thr Glu Thr His Asp Lys Thr Asp Gly His Val Tyr Asn Tyr Ile 
        675                 680                 685             


Pro Pro Pro Val Gly Gln Met Cys Gln Asn Pro Ile Tyr Met Gln Lys 
    690                 695                 700                 


Glu Gly Asp Pro Val Ala Tyr Tyr Arg Asn Leu Gln Glu Phe Ser Tyr 
705                 710                 715                 720 


Ser Asn Leu Glu Glu Lys Lys Glu Glu Pro Ala Thr Pro Ala Tyr Thr 
                725                 730                 735     


Ile Ser Ala Thr Glu Leu Leu Glu Lys Gln Ala Thr Pro Arg Glu Pro 
            740                 745                 750         


Glu Leu Leu Tyr Gln Asn Ile Ala Glu Arg Val Lys Glu Leu Pro Ser 
        755                 760                 765             


Ala Gly Leu Val His Tyr Asn Phe Cys Thr Leu Pro Lys Arg Gln Phe 
    770                 775                 780                 


Ala Pro Ser Tyr Glu Ser Arg Arg Gln Asn Gln Asp Arg Ile Asn Lys 
785                 790                 795                 800 


Thr Val Leu Tyr Gly Thr Pro Arg Lys Cys Phe Val Gly Gln Ser Lys 
                805                 810                 815     


Pro Asn His Pro Leu Leu Gln Ala Lys Pro Gln Ser Glu Pro Asp Tyr 
            820                 825                 830         


Leu Glu Val Leu Glu Lys Gln Thr Ala Ile Ser Gln Leu 
        835                 840                 845 


<210>  1755
<211>  845
<212>  PRT
<213>  Homo sapiens

<400>  1755

Met Leu Ser Gly Val Trp Phe Leu Ser Val Leu Thr Val Ala Gly Ile 
1               5                   10                  15      


Leu Gln Thr Glu Ser Arg Lys Thr Ala Lys Asp Ile Cys Lys Ile Arg 
            20                  25                  30          


Cys Leu Cys Glu Glu Lys Glu Asn Val Leu Asn Ile Asn Cys Glu Asn 
        35                  40                  45              


Lys Gly Phe Thr Thr Val Ser Leu Leu Gln Pro Pro Gln Tyr Arg Ile 
    50                  55                  60                  


Tyr Gln Leu Phe Leu Asn Gly Asn Leu Leu Thr Arg Leu Tyr Pro Asn 
65                  70                  75                  80  


Glu Phe Val Asn Tyr Ser Asn Ala Val Thr Leu His Leu Gly Asn Asn 
                85                  90                  95      


Gly Leu Gln Glu Ile Arg Thr Gly Ala Phe Ser Gly Leu Lys Thr Leu 
            100                 105                 110         


Lys Arg Leu His Leu Asn Asn Asn Lys Leu Glu Ile Leu Arg Glu Asp 
        115                 120                 125             


Thr Phe Leu Gly Leu Glu Ser Leu Glu Tyr Leu Gln Ala Asp Tyr Asn 
    130                 135                 140                 


Tyr Ile Ser Ala Ile Glu Ala Gly Ala Phe Ser Lys Leu Asn Lys Leu 
145                 150                 155                 160 


Lys Val Leu Ile Leu Asn Asp Asn Leu Leu Leu Ser Leu Pro Ser Asn 
                165                 170                 175     


Val Phe Arg Phe Val Leu Leu Thr His Leu Asp Leu Arg Gly Asn Arg 
            180                 185                 190         


Leu Lys Val Met Pro Phe Ala Gly Val Leu Glu His Ile Gly Gly Ile 
        195                 200                 205             


Met Glu Ile Gln Leu Glu Glu Asn Pro Trp Asn Cys Thr Cys Asp Leu 
    210                 215                 220                 


Leu Pro Leu Lys Ala Trp Leu Asp Thr Ile Thr Val Phe Val Gly Glu 
225                 230                 235                 240 


Ile Val Cys Glu Thr Pro Phe Arg Leu His Gly Lys Asp Val Thr Gln 
                245                 250                 255     


Leu Thr Arg Gln Asp Leu Cys Pro Arg Lys Ser Ala Ser Asp Ser Ser 
            260                 265                 270         


Gln Arg Gly Ser His Ala Asp Thr His Val Gln Arg Leu Ser Pro Thr 
        275                 280                 285             


Met Asn Pro Ala Leu Asn Pro Thr Arg Ala Pro Lys Ala Ser Arg Pro 
    290                 295                 300                 


Pro Lys Met Arg Asn Arg Pro Thr Pro Arg Val Thr Val Ser Lys Asp 
305                 310                 315                 320 


Arg Gln Ser Phe Gly Pro Ile Met Val Tyr Gln Thr Lys Ser Pro Val 
                325                 330                 335     


Pro Leu Thr Cys Pro Ser Ser Cys Val Cys Thr Ser Gln Ser Ser Asp 
            340                 345                 350         


Asn Gly Leu Asn Val Asn Cys Gln Glu Arg Lys Phe Thr Asn Ile Ser 
        355                 360                 365             


Asp Leu Gln Pro Lys Pro Thr Ser Pro Lys Lys Leu Tyr Leu Thr Gly 
    370                 375                 380                 


Asn Tyr Leu Gln Thr Val Tyr Lys Asn Asp Leu Leu Glu Tyr Ser Ser 
385                 390                 395                 400 


Leu Asp Leu Leu His Leu Gly Asn Asn Arg Ile Ala Val Ile Gln Glu 
                405                 410                 415     


Gly Ala Phe Thr Asn Leu Thr Ser Leu Arg Arg Leu Tyr Leu Asn Gly 
            420                 425                 430         


Asn Tyr Leu Glu Val Leu Tyr Pro Ser Met Phe Asp Gly Leu Gln Ser 
        435                 440                 445             


Leu Gln Tyr Leu Tyr Leu Glu Tyr Asn Val Ile Lys Glu Ile Lys Pro 
    450                 455                 460                 


Leu Thr Phe Asp Ala Leu Ile Asn Leu Gln Leu Leu Phe Leu Asn Asn 
465                 470                 475                 480 


Asn Leu Leu Arg Ser Leu Pro Asp Asn Ile Phe Gly Gly Thr Ala Leu 
                485                 490                 495     


Thr Arg Leu Asn Leu Arg Asn Asn His Phe Ser His Leu Pro Val Lys 
            500                 505                 510         


Gly Val Leu Asp Gln Leu Pro Ala Phe Ile Gln Ile Asp Leu Gln Glu 
        515                 520                 525             


Asn Pro Trp Asp Cys Thr Cys Asp Ile Met Gly Leu Lys Asp Trp Thr 
    530                 535                 540                 


Glu His Ala Asn Ser Pro Val Ile Ile Asn Glu Val Thr Cys Glu Ser 
545                 550                 555                 560 


Pro Ala Lys His Ala Gly Glu Ile Leu Lys Phe Leu Gly Arg Glu Ala 
                565                 570                 575     


Ile Cys Pro Asp Ser Pro Asn Leu Ser Asp Gly Thr Val Leu Ser Met 
            580                 585                 590         


Asn His Asn Thr Asp Thr Pro Arg Ser Leu Ser Val Ser Pro Ser Ser 
        595                 600                 605             


Tyr Pro Glu Leu His Thr Glu Val Pro Leu Ser Val Leu Ile Leu Gly 
    610                 615                 620                 


Leu Leu Val Val Phe Ile Leu Ser Val Cys Phe Gly Ala Gly Leu Phe 
625                 630                 635                 640 


Val Phe Val Leu Lys Arg Arg Lys Gly Val Pro Ser Val Pro Arg Asn 
                645                 650                 655     


Thr Asn Asn Leu Asp Val Ser Ser Phe Gln Leu Gln Tyr Gly Ser Tyr 
            660                 665                 670         


Asn Thr Glu Thr His Asp Lys Thr Asp Gly His Val Tyr Asn Tyr Ile 
        675                 680                 685             


Pro Pro Pro Val Gly Gln Met Cys Gln Asn Pro Ile Tyr Met Gln Lys 
    690                 695                 700                 


Glu Gly Asp Pro Val Ala Tyr Tyr Arg Asn Leu Gln Glu Phe Ser Tyr 
705                 710                 715                 720 


Ser Asn Leu Glu Glu Lys Lys Glu Glu Pro Ala Thr Pro Ala Tyr Thr 
                725                 730                 735     


Ile Ser Ala Thr Glu Leu Leu Glu Lys Gln Ala Thr Pro Arg Glu Pro 
            740                 745                 750         


Glu Leu Leu Tyr Gln Asn Ile Ala Glu Arg Val Lys Glu Leu Pro Ser 
        755                 760                 765             


Ala Gly Leu Val His Tyr Asn Phe Cys Thr Leu Pro Lys Arg Gln Phe 
    770                 775                 780                 


Ala Pro Ser Tyr Glu Ser Arg Arg Gln Asn Gln Asp Arg Ile Asn Lys 
785                 790                 795                 800 


Thr Val Leu Tyr Gly Thr Pro Arg Lys Cys Phe Val Gly Gln Ser Lys 
                805                 810                 815     


Pro Asn His Pro Leu Leu Gln Ala Lys Pro Gln Ser Glu Pro Asp Tyr 
            820                 825                 830         


Leu Glu Val Leu Glu Lys Gln Thr Ala Ile Ser Gln Leu 
        835                 840                 845 


<210>  1756
<211>  845
<212>  PRT
<213>  Homo sapiens

<400>  1756

Met Leu Ser Gly Val Trp Phe Leu Ser Val Leu Thr Val Ala Gly Ile 
1               5                   10                  15      


Leu Gln Thr Glu Ser Arg Lys Thr Ala Lys Asp Ile Cys Lys Ile Arg 
            20                  25                  30          


Cys Leu Cys Glu Glu Lys Glu Asn Val Leu Asn Ile Asn Cys Glu Asn 
        35                  40                  45              


Lys Gly Phe Thr Thr Val Ser Leu Leu Gln Pro Pro Gln Tyr Arg Ile 
    50                  55                  60                  


Tyr Gln Leu Phe Leu Asn Gly Asn Leu Leu Thr Arg Leu Tyr Pro Asn 
65                  70                  75                  80  


Glu Phe Val Asn Tyr Ser Asn Ala Val Thr Leu His Leu Gly Asn Asn 
                85                  90                  95      


Gly Leu Gln Glu Ile Arg Thr Gly Ala Phe Ser Gly Leu Lys Thr Leu 
            100                 105                 110         


Lys Arg Leu His Leu Asn Asn Asn Lys Leu Glu Ile Leu Arg Glu Asp 
        115                 120                 125             


Thr Phe Leu Gly Leu Glu Ser Leu Glu Tyr Leu Gln Ala Asp Tyr Asn 
    130                 135                 140                 


Tyr Ile Ser Ala Ile Glu Ala Gly Ala Phe Ser Lys Leu Asn Lys Leu 
145                 150                 155                 160 


Lys Val Leu Ile Leu Asn Asp Asn Leu Leu Leu Ser Leu Pro Ser Asn 
                165                 170                 175     


Val Phe Arg Phe Val Leu Leu Thr His Leu Asp Leu Arg Gly Asn Arg 
            180                 185                 190         


Leu Lys Val Met Pro Phe Ala Gly Val Leu Glu His Ile Gly Gly Ile 
        195                 200                 205             


Met Glu Ile Gln Leu Glu Glu Asn Pro Trp Asn Cys Thr Cys Asp Leu 
    210                 215                 220                 


Leu Pro Leu Lys Ala Trp Leu Asp Thr Ile Thr Val Phe Val Gly Glu 
225                 230                 235                 240 


Ile Val Cys Glu Thr Pro Phe Arg Leu His Gly Lys Asp Val Thr Gln 
                245                 250                 255     


Leu Thr Arg Gln Asp Leu Cys Pro Arg Lys Ser Ala Ser Asp Ser Ser 
            260                 265                 270         


Gln Arg Gly Ser His Ala Asp Thr His Val Gln Arg Leu Ser Pro Thr 
        275                 280                 285             


Met Asn Pro Ala Leu Asn Pro Thr Arg Ala Pro Lys Ala Ser Arg Pro 
    290                 295                 300                 


Pro Lys Met Arg Asn Arg Pro Thr Pro Arg Val Thr Val Ser Lys Asp 
305                 310                 315                 320 


Arg Gln Ser Phe Gly Pro Ile Met Val Tyr Gln Thr Lys Ser Pro Val 
                325                 330                 335     


Pro Leu Thr Cys Pro Ser Ser Cys Val Cys Thr Ser Gln Ser Ser Asp 
            340                 345                 350         


Asn Gly Leu Asn Val Asn Cys Gln Glu Arg Lys Phe Thr Asn Ile Ser 
        355                 360                 365             


Asp Leu Gln Pro Lys Pro Thr Ser Pro Lys Lys Leu Tyr Leu Thr Gly 
    370                 375                 380                 


Asn Tyr Leu Gln Thr Val Tyr Lys Asn Asp Leu Leu Glu Tyr Ser Ser 
385                 390                 395                 400 


Leu Asp Leu Leu His Leu Gly Asn Asn Arg Ile Ala Val Ile Gln Glu 
                405                 410                 415     


Gly Ala Phe Thr Asn Leu Thr Ser Leu Arg Arg Leu Tyr Leu Asn Gly 
            420                 425                 430         


Asn Tyr Leu Glu Val Leu Tyr Pro Ser Met Phe Asp Gly Leu Gln Ser 
        435                 440                 445             


Leu Gln Tyr Leu Tyr Leu Glu Tyr Asn Val Ile Lys Glu Ile Lys Pro 
    450                 455                 460                 


Leu Thr Phe Asp Ala Leu Ile Asn Leu Gln Leu Leu Phe Leu Asn Asn 
465                 470                 475                 480 


Asn Leu Leu Arg Ser Leu Pro Asp Asn Ile Phe Gly Gly Thr Ala Leu 
                485                 490                 495     


Thr Arg Leu Asn Leu Arg Asn Asn His Phe Ser His Leu Pro Val Lys 
            500                 505                 510         


Gly Val Leu Asp Gln Leu Pro Ala Phe Ile Gln Ile Asp Leu Gln Glu 
        515                 520                 525             


Asn Pro Trp Asp Cys Thr Cys Asp Ile Met Gly Leu Lys Asp Trp Thr 
    530                 535                 540                 


Glu His Ala Asn Ser Pro Val Ile Ile Asn Glu Val Thr Cys Glu Ser 
545                 550                 555                 560 


Pro Ala Lys His Ala Gly Glu Ile Leu Lys Phe Leu Gly Arg Glu Ala 
                565                 570                 575     


Ile Cys Pro Asp Ser Pro Asn Leu Ser Asp Gly Thr Val Leu Ser Met 
            580                 585                 590         


Asn His Asn Thr Asp Thr Pro Arg Ser Leu Ser Val Ser Pro Ser Ser 
        595                 600                 605             


Tyr Pro Glu Leu His Thr Glu Val Pro Leu Ser Val Leu Ile Leu Gly 
    610                 615                 620                 


Leu Leu Val Val Phe Ile Leu Ser Val Cys Phe Gly Ala Gly Leu Phe 
625                 630                 635                 640 


Val Phe Val Leu Lys Arg Arg Lys Gly Val Pro Ser Val Pro Arg Asn 
                645                 650                 655     


Thr Asn Asn Leu Asp Val Ser Ser Phe Gln Leu Gln Tyr Gly Ser Tyr 
            660                 665                 670         


Asn Thr Glu Thr His Asp Lys Thr Asp Gly His Val Tyr Asn Tyr Ile 
        675                 680                 685             


Pro Pro Pro Val Gly Gln Met Cys Gln Asn Pro Ile Tyr Met Gln Lys 
    690                 695                 700                 


Glu Gly Asp Pro Val Ala Tyr Tyr Arg Asn Leu Gln Glu Phe Ser Tyr 
705                 710                 715                 720 


Ser Asn Leu Glu Glu Lys Lys Glu Glu Pro Ala Thr Pro Ala Tyr Thr 
                725                 730                 735     


Ile Ser Ala Thr Glu Leu Leu Glu Lys Gln Ala Thr Pro Arg Glu Pro 
            740                 745                 750         


Glu Leu Leu Tyr Gln Asn Ile Ala Glu Arg Val Lys Glu Leu Pro Ser 
        755                 760                 765             


Ala Gly Leu Val His Tyr Asn Phe Cys Thr Leu Pro Lys Arg Gln Phe 
    770                 775                 780                 


Ala Pro Ser Tyr Glu Ser Arg Arg Gln Asn Gln Asp Arg Ile Asn Lys 
785                 790                 795                 800 


Thr Val Leu Tyr Gly Thr Pro Arg Lys Cys Phe Val Gly Gln Ser Lys 
                805                 810                 815     


Pro Asn His Pro Leu Leu Gln Ala Lys Pro Gln Ser Glu Pro Asp Tyr 
            820                 825                 830         


Leu Glu Val Leu Glu Lys Gln Thr Ala Ile Ser Gln Leu 
        835                 840                 845 


<210>  1757
<211>  845
<212>  PRT
<213>  Homo sapiens

<400>  1757

Met Leu Ser Gly Val Trp Phe Leu Ser Val Leu Thr Val Ala Gly Ile 
1               5                   10                  15      


Leu Gln Thr Glu Ser Arg Lys Thr Ala Lys Asp Ile Cys Lys Ile Arg 
            20                  25                  30          


Cys Leu Cys Glu Glu Lys Glu Asn Val Leu Asn Ile Asn Cys Glu Asn 
        35                  40                  45              


Lys Gly Phe Thr Thr Val Ser Leu Leu Gln Pro Pro Gln Tyr Arg Ile 
    50                  55                  60                  


Tyr Gln Leu Phe Leu Asn Gly Asn Leu Leu Thr Arg Leu Tyr Pro Asn 
65                  70                  75                  80  


Glu Phe Val Asn Tyr Ser Asn Ala Val Thr Leu His Leu Gly Asn Asn 
                85                  90                  95      


Gly Leu Gln Glu Ile Arg Thr Gly Ala Phe Ser Gly Leu Lys Thr Leu 
            100                 105                 110         


Lys Arg Leu His Leu Asn Asn Asn Lys Leu Glu Ile Leu Arg Glu Asp 
        115                 120                 125             


Thr Phe Leu Gly Leu Glu Ser Leu Glu Tyr Leu Gln Ala Asp Tyr Asn 
    130                 135                 140                 


Tyr Ile Ser Ala Ile Glu Ala Gly Ala Phe Ser Lys Leu Asn Lys Leu 
145                 150                 155                 160 


Lys Val Leu Ile Leu Asn Asp Asn Leu Leu Leu Ser Leu Pro Ser Asn 
                165                 170                 175     


Val Phe Arg Phe Val Leu Leu Thr His Leu Asp Leu Arg Gly Asn Arg 
            180                 185                 190         


Leu Lys Val Met Pro Phe Ala Gly Val Leu Glu His Ile Gly Gly Ile 
        195                 200                 205             


Met Glu Ile Gln Leu Glu Glu Asn Pro Trp Asn Cys Thr Cys Asp Leu 
    210                 215                 220                 


Leu Pro Leu Lys Ala Trp Leu Asp Thr Ile Thr Val Phe Val Gly Glu 
225                 230                 235                 240 


Ile Val Cys Glu Thr Pro Phe Arg Leu His Gly Lys Asp Val Thr Gln 
                245                 250                 255     


Leu Thr Arg Gln Asp Leu Cys Pro Arg Lys Ser Ala Ser Asp Ser Ser 
            260                 265                 270         


Gln Arg Gly Ser His Ala Asp Thr His Val Gln Arg Leu Ser Pro Thr 
        275                 280                 285             


Met Asn Pro Ala Leu Asn Pro Thr Arg Ala Pro Lys Ala Ser Arg Pro 
    290                 295                 300                 


Pro Lys Met Arg Asn Arg Pro Thr Pro Arg Val Thr Val Ser Lys Asp 
305                 310                 315                 320 


Arg Gln Ser Phe Gly Pro Ile Met Val Tyr Gln Thr Lys Ser Pro Val 
                325                 330                 335     


Pro Leu Thr Cys Pro Ser Ser Cys Val Cys Thr Ser Gln Ser Ser Asp 
            340                 345                 350         


Asn Gly Leu Asn Val Asn Cys Gln Glu Arg Lys Phe Thr Asn Ile Ser 
        355                 360                 365             


Asp Leu Gln Pro Lys Pro Thr Ser Pro Lys Lys Leu Tyr Leu Thr Gly 
    370                 375                 380                 


Asn Tyr Leu Gln Thr Val Tyr Lys Asn Asp Leu Leu Glu Tyr Ser Ser 
385                 390                 395                 400 


Leu Asp Leu Leu His Leu Gly Asn Asn Arg Ile Ala Val Ile Gln Glu 
                405                 410                 415     


Gly Ala Phe Thr Asn Leu Thr Ser Leu Arg Arg Leu Tyr Leu Asn Gly 
            420                 425                 430         


Asn Tyr Leu Glu Val Leu Tyr Pro Ser Met Phe Asp Gly Leu Gln Ser 
        435                 440                 445             


Leu Gln Tyr Leu Tyr Leu Glu Tyr Asn Val Ile Lys Glu Ile Lys Pro 
    450                 455                 460                 


Leu Thr Phe Asp Ala Leu Ile Asn Leu Gln Leu Leu Phe Leu Asn Asn 
465                 470                 475                 480 


Asn Leu Leu Arg Ser Leu Pro Asp Asn Ile Phe Gly Gly Thr Ala Leu 
                485                 490                 495     


Thr Arg Leu Asn Leu Arg Asn Asn His Phe Ser His Leu Pro Val Lys 
            500                 505                 510         


Gly Val Leu Asp Gln Leu Pro Ala Phe Ile Gln Ile Asp Leu Gln Glu 
        515                 520                 525             


Asn Pro Trp Asp Cys Thr Cys Asp Ile Met Gly Leu Lys Asp Trp Thr 
    530                 535                 540                 


Glu His Ala Asn Ser Pro Val Ile Ile Asn Glu Val Thr Cys Glu Ser 
545                 550                 555                 560 


Pro Ala Lys His Ala Gly Glu Ile Leu Lys Phe Leu Gly Arg Glu Ala 
                565                 570                 575     


Ile Cys Pro Asp Ser Pro Asn Leu Ser Asp Gly Thr Val Leu Ser Met 
            580                 585                 590         


Asn His Asn Thr Asp Thr Pro Arg Ser Leu Ser Val Ser Pro Ser Ser 
        595                 600                 605             


Tyr Pro Glu Leu His Thr Glu Val Pro Leu Ser Val Leu Ile Leu Gly 
    610                 615                 620                 


Leu Leu Val Val Phe Ile Leu Ser Val Cys Phe Gly Ala Gly Leu Phe 
625                 630                 635                 640 


Val Phe Val Leu Lys Arg Arg Lys Gly Val Pro Ser Val Pro Arg Asn 
                645                 650                 655     


Thr Asn Asn Leu Asp Val Ser Ser Phe Gln Leu Gln Tyr Gly Ser Tyr 
            660                 665                 670         


Asn Thr Glu Thr His Asp Lys Thr Asp Gly His Val Tyr Asn Tyr Ile 
        675                 680                 685             


Pro Pro Pro Val Gly Gln Met Cys Gln Asn Pro Ile Tyr Met Gln Lys 
    690                 695                 700                 


Glu Gly Asp Pro Val Ala Tyr Tyr Arg Asn Leu Gln Glu Phe Ser Tyr 
705                 710                 715                 720 


Ser Asn Leu Glu Glu Lys Lys Glu Glu Pro Ala Thr Pro Ala Tyr Thr 
                725                 730                 735     


Ile Ser Ala Thr Glu Leu Leu Glu Lys Gln Ala Thr Pro Arg Glu Pro 
            740                 745                 750         


Glu Leu Leu Tyr Gln Asn Ile Ala Glu Arg Val Lys Glu Leu Pro Ser 
        755                 760                 765             


Ala Gly Leu Val His Tyr Asn Phe Cys Thr Leu Pro Lys Arg Gln Phe 
    770                 775                 780                 


Ala Pro Ser Tyr Glu Ser Arg Arg Gln Asn Gln Asp Arg Ile Asn Lys 
785                 790                 795                 800 


Thr Val Leu Tyr Gly Thr Pro Arg Lys Cys Phe Val Gly Gln Ser Lys 
                805                 810                 815     


Pro Asn His Pro Leu Leu Gln Ala Lys Pro Gln Ser Glu Pro Asp Tyr 
            820                 825                 830         


Leu Glu Val Leu Glu Lys Gln Thr Ala Ile Ser Gln Leu 
        835                 840                 845 


<210>  1758
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  1758

Met Ala Val Leu Ala Pro Leu Ile Ala Leu Val Tyr Ser Val Pro Arg 
1               5                   10                  15      


Leu Ser Arg Trp Leu Ala Gln Pro Tyr Tyr Leu Leu Ser Ala Leu Leu 
            20                  25                  30          


Ser Ala Ala Phe Leu Leu Val Arg Lys Leu Pro Pro Leu Cys His Gly 
        35                  40                  45              


Leu Pro Thr Gln Arg Glu Asp Gly Asn Pro Cys Asp Phe Asp Trp Arg 
    50                  55                  60                  


Glu Val Glu Ile Leu Met Phe Leu Ser Ala Ile Val Met Met Lys Asn 
65                  70                  75                  80  


Arg Arg Ser Met Phe Leu Met Thr Cys Lys Pro Pro Leu Tyr Met Gly 
                85                  90                  95      


Pro Glu Tyr Ile Lys Tyr Phe Asn Asp Lys Thr Ile Asp Glu Glu Leu 
            100                 105                 110         


Glu Arg Asp Lys Arg Val Thr Trp Ile Val Glu Phe Phe Ala Asn Trp 
        115                 120                 125             


Ser Asn Asp Cys Gln Ser Phe Ala Pro Ile Tyr Ala Asp Leu Ser Leu 
    130                 135                 140                 


Lys Tyr Asn Cys Thr Gly Leu Asn Phe Gly Lys Val Asp Val Gly Arg 
145                 150                 155                 160 


Tyr Thr Asp Val Ser Thr Arg Tyr Lys Val Ser Thr Ser Pro Leu Thr 
                165                 170                 175     


Lys Gln Leu Pro Thr Leu Ile Leu Phe Gln Gly Gly Lys Glu Ala Met 
            180                 185                 190         


Arg Arg Pro Gln Ile Asp Lys Lys Gly Arg Ala Val Ser Trp Thr Phe 
        195                 200                 205             


Ser Glu Glu Asn Val Ile Arg Glu Phe Asn Leu Asn Glu Leu Tyr Gln 
    210                 215                 220                 


Arg Ala Lys Lys Leu Ser Lys Ala Gly Asp Asn Ile Pro Glu Glu Gln 
225                 230                 235                 240 


Pro Val Ala Ser Thr Pro Thr Thr Val Ser Asp Gly Glu Asn Lys Lys 
                245                 250                 255     


Asp Lys 
        


<210>  1759
<211>  953
<212>  PRT
<213>  Homo sapiens

<400>  1759

Met Arg Gln Leu Gln Lys Lys Ile Lys Asn Gly Thr Leu Asn Ile Lys 
1               5                   10                  15      


Gln Asp Asp Pro Phe Glu Leu Phe Ile Ala Ala Thr Asn Ile Arg Tyr 
            20                  25                  30          


Cys Tyr Tyr Asn Glu Thr His Lys Ile Leu Gly Asn Thr Phe Gly Met 
        35                  40                  45              


Cys Val Leu Gln Asp Phe Glu Ala Leu Thr Pro Asn Leu Leu Ala Arg 
    50                  55                  60                  


Thr Val Glu Thr Val Glu Gly Gly Gly Leu Val Val Ile Leu Leu Arg 
65                  70                  75                  80  


Thr Met Asn Ser Leu Lys Gln Leu Tyr Thr Val Thr Met Asp Val His 
                85                  90                  95      


Ser Arg Tyr Arg Thr Glu Ala His Gln Asp Val Val Gly Arg Phe Asn 
            100                 105                 110         


Glu Arg Phe Ile Leu Ser Leu Ala Ser Cys Lys Lys Cys Leu Val Ile 
        115                 120                 125             


Asp Asp Gln Leu Asn Ile Leu Pro Ile Ser Ser His Val Ala Thr Met 
    130                 135                 140                 


Glu Ala Leu Pro Pro Gln Thr Pro Asp Glu Ser Leu Gly Pro Ser Asp 
145                 150                 155                 160 


Leu Glu Leu Arg Glu Leu Lys Glu Ser Leu Gln Asp Thr Gln Pro Val 
                165                 170                 175     


Gly Val Leu Val Asp Cys Cys Lys Thr Leu Asp Gln Ala Lys Ala Val 
            180                 185                 190         


Leu Lys Phe Ile Glu Gly Ile Ser Glu Lys Thr Leu Arg Ser Thr Val 
        195                 200                 205             


Ala Leu Thr Ala Ala Arg Gly Arg Gly Lys Ser Ala Ala Leu Gly Leu 
    210                 215                 220                 


Ala Ile Ala Gly Ala Val Ala Phe Gly Tyr Ser Asn Ile Phe Val Thr 
225                 230                 235                 240 


Ser Pro Ser Pro Asp Asn Leu His Thr Leu Phe Glu Phe Val Phe Lys 
                245                 250                 255     


Gly Phe Asp Ala Leu Gln Tyr Gln Glu His Leu Asp Tyr Glu Ile Ile 
            260                 265                 270         


Gln Ser Leu Asn Pro Glu Phe Asn Lys Ala Val Ile Arg Val Asn Val 
        275                 280                 285             


Phe Arg Glu His Arg Gln Thr Ile Gln Tyr Ile His Pro Ala Asp Ala 
    290                 295                 300                 


Val Lys Leu Gly Gln Ala Glu Leu Val Val Ile Asp Glu Ala Ala Ala 
305                 310                 315                 320 


Ile Pro Leu Pro Leu Val Lys Ser Leu Leu Gly Pro Tyr Leu Val Phe 
                325                 330                 335     


Met Ala Ser Thr Ile Asn Gly Tyr Glu Gly Thr Gly Arg Ser Leu Ser 
            340                 345                 350         


Leu Lys Leu Ile Gln Gln Leu Arg Gln Gln Ser Ala Gln Ser Gln Val 
        355                 360                 365             


Ser Thr Thr Ala Glu Asn Lys Thr Thr Thr Thr Ala Arg Leu Ala Ser 
    370                 375                 380                 


Ala Arg Thr Leu His Glu Val Ser Leu Gln Glu Ser Ile Arg Tyr Ala 
385                 390                 395                 400 


Pro Gly Asp Ala Val Glu Lys Trp Leu Asn Asp Leu Leu Cys Leu Asp 
                405                 410                 415     


Cys Leu Asn Ile Thr Arg Ile Val Ser Gly Cys Pro Leu Pro Glu Ala 
            420                 425                 430         


Cys Glu Leu Tyr Tyr Val Asn Arg Asp Thr Leu Phe Cys Tyr His Lys 
        435                 440                 445             


Ala Ser Glu Val Phe Leu Gln Arg Leu Met Ala Leu Tyr Val Ala Ser 
    450                 455                 460                 


His Tyr Lys Asn Ser Pro Asn Asp Leu Gln Met Leu Ser Asp Ala Pro 
465                 470                 475                 480 


Ala His His Leu Phe Cys Leu Leu Pro Pro Val Pro Pro Thr Gln Asn 
                485                 490                 495     


Ala Leu Pro Glu Val Leu Ala Val Ile Gln Val Cys Leu Glu Gly Glu 
            500                 505                 510         


Ile Ser Arg Gln Ser Ile Leu Asn Ser Leu Ser Arg Gly Lys Lys Ala 
        515                 520                 525             


Ser Gly Asp Leu Ile Pro Trp Thr Val Ser Glu Gln Phe Gln Asp Pro 
    530                 535                 540                 


Asp Phe Gly Gly Leu Ser Gly Gly Arg Val Val Arg Ile Ala Val His 
545                 550                 555                 560 


Pro Asp Tyr Gln Gly Met Gly Tyr Gly Ser Arg Ala Leu Gln Leu Leu 
                565                 570                 575     


Gln Met Tyr Tyr Glu Gly Arg Phe Pro Cys Leu Glu Glu Lys Val Leu 
            580                 585                 590         


Glu Thr Pro Gln Glu Ile His Thr Val Ser Ser Glu Ala Val Ser Leu 
        595                 600                 605             


Leu Glu Glu Val Ile Thr Pro Arg Lys Asp Leu Pro Pro Leu Leu Leu 
    610                 615                 620                 


Lys Leu Asn Glu Arg Pro Ala Glu Arg Leu Asp Tyr Leu Gly Val Ser 
625                 630                 635                 640 


Tyr Gly Leu Thr Pro Arg Leu Leu Lys Phe Trp Lys Arg Ala Gly Phe 
                645                 650                 655     


Val Pro Val Tyr Leu Arg Gln Thr Pro Asn Asp Leu Thr Gly Glu His 
            660                 665                 670         


Ser Cys Ile Met Leu Lys Thr Leu Thr Asp Glu Asp Glu Ala Asp Gln 
        675                 680                 685             


Gly Gly Trp Leu Ala Ala Phe Trp Lys Asp Phe Arg Arg Arg Phe Leu 
    690                 695                 700                 


Ala Leu Leu Ser Tyr Gln Phe Ser Thr Phe Ser Pro Ser Leu Ala Leu 
705                 710                 715                 720 


Asn Ile Ile Gln Asn Arg Asn Met Gly Lys Pro Ala Gln Pro Ala Leu 
                725                 730                 735     


Ser Arg Glu Glu Leu Glu Ala Leu Phe Leu Pro Tyr Asp Leu Lys Arg 
            740                 745                 750         


Leu Glu Met Tyr Ser Arg Asn Met Val Asp Tyr His Leu Ile Met Asp 
        755                 760                 765             


Met Ile Pro Ala Ile Ser Arg Ile Tyr Phe Leu Asn Gln Leu Gly Asp 
    770                 775                 780                 


Leu Ala Leu Ser Ala Ala Gln Ser Ala Leu Leu Leu Gly Ile Gly Leu 
785                 790                 795                 800 


Gln His Lys Ser Val Asp Gln Leu Glu Lys Glu Ile Glu Leu Pro Ser 
                805                 810                 815     


Gly Gln Leu Met Gly Leu Phe Asn Arg Ile Ile Arg Lys Val Val Lys 
            820                 825                 830         


Leu Phe Asn Glu Val Gln Glu Lys Ala Ile Glu Glu Gln Met Val Ala 
        835                 840                 845             


Ala Lys Asp Val Val Met Glu Pro Thr Met Lys Thr Leu Ser Asp Asp 
    850                 855                 860                 


Leu Asp Glu Ala Ala Lys Glu Phe Gln Glu Lys His Lys Lys Glu Val 
865                 870                 875                 880 


Gly Lys Leu Lys Ser Met Asp Leu Ser Glu Tyr Ile Ile Arg Gly Asp 
                885                 890                 895     


Asp Glu Glu Trp Asn Glu Val Leu Asn Lys Ala Gly Pro Asn Ala Ser 
            900                 905                 910         


Ile Ile Ser Leu Lys Ser Asp Lys Lys Arg Lys Leu Glu Ala Lys Gln 
        915                 920                 925             


Glu Pro Lys Gln Ser Lys Lys Leu Lys Asn Arg Glu Thr Lys Asn Lys 
    930                 935                 940                 


Lys Asp Met Lys Leu Lys Arg Lys Lys 
945                 950             


<210>  1760
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  1760

Met Asn Ser Arg Gly Glu Leu Val Gly Val Asn Asn Lys Arg Leu Gly 
1               5                   10                  15      


Val Cys Gly Trp Ile Leu Phe Ser Leu Ser Phe Leu Leu Val Ile Ile 
            20                  25                  30          


Thr Phe Pro Ile Ser Ile Trp Met Cys Leu Lys Ile Ile Lys Glu Tyr 
        35                  40                  45              


Glu Arg Ala Val Val Phe Arg Leu Gly Arg Ile Gln Ala Asp Lys Ala 
    50                  55                  60                  


Lys Gly Pro Gly Leu Ile Leu Val Leu Pro Cys Ile Asp Val Phe Val 
65                  70                  75                  80  


Lys Val Asp Leu Arg Thr Val Thr Cys Asn Ile Pro Pro Gln Glu Ile 
                85                  90                  95      


Leu Thr Arg Asp Ser Val Thr Thr Gln Val Asp Gly Val Val Tyr Tyr 
            100                 105                 110         


Arg Ile Tyr Ser Ala Val Ser Ala Val Ala Asn Val Asn Asp Val His 
        115                 120                 125             


Gln Ala Thr Phe Leu Leu Ala Gln Thr Thr Leu Arg Asn Val Leu Gly 
    130                 135                 140                 


Thr Gln Thr Leu Ser Gln Ile Leu Ala Gly Arg Glu Glu Ile Ala His 
145                 150                 155                 160 


Ser Ile Gln Thr Leu Leu Asp Asp Ala Thr Glu Leu Trp Gly Ile Arg 
                165                 170                 175     


Val Ala Arg Val Glu Ile Lys Asp Val Arg Ile Pro Val Gln Leu Gln 
            180                 185                 190         


Arg Ser Met Ala Ala Glu Ala Glu Ala Thr Arg Glu Ala Arg Ala Lys 
        195                 200                 205             


Val Leu Ala Ala Glu Gly Glu Met Asn Ala Ser Lys Ser Leu Lys Ser 
    210                 215                 220                 


Ala Ser Met Val Leu Ala Glu Ser Pro Ile Ala Leu Gln Leu Arg Tyr 
225                 230                 235                 240 


Leu Gln Thr Leu Ser Thr Val Ala Thr Glu Lys Asn Ser Thr Ile Val 
                245                 250                 255     


Phe Pro Leu Pro Met Asn Ile Leu Glu Gly Ile Gly Gly Val Ser Tyr 
            260                 265                 270         


Asp Asn His Lys Lys Leu Pro Asn Lys Ala 
        275                 280         


<210>  1761
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  1761

Met Ala Leu Pro Pro Gly Pro Ala Ala Leu Arg His Thr Leu Leu Leu 
1               5                   10                  15      


Leu Pro Ala Leu Leu Ser Ser Gly Trp Gly Glu Leu Glu Pro Gln Ile 
            20                  25                  30          


Asp Gly Gln Thr Trp Ala Glu Arg Ala Leu Arg Glu Asn Glu Arg His 
        35                  40                  45              


Ala Phe Thr Cys Arg Val Ala Gly Gly Pro Gly Thr Pro Arg Leu Ala 
    50                  55                  60                  


Trp Tyr Leu Asp Gly Gln Leu Gln Glu Ala Ser Thr Ser Arg Leu Leu 
65                  70                  75                  80  


Ser Val Gly Gly Glu Ala Phe Ser Gly Gly Thr Ser Thr Phe Thr Val 
                85                  90                  95      


Thr Ala His Arg Ala Gln His Glu Leu Asn Cys Ser Leu Gln Asp Pro 
            100                 105                 110         


Arg Ser Gly Arg Ser Ala Asn Ala Ser Val Ile Leu Asn Val Gln Phe 
        115                 120                 125             


Lys Pro Glu Ile Ala Gln Val Gly Ala Lys Tyr Gln Glu Ala Gln Gly 
    130                 135                 140                 


Pro Gly Leu Leu Val Val Leu Phe Ala Leu Val Arg Ala Asn Pro Pro 
145                 150                 155                 160 


Ala Asn Val Thr Trp Ile Asp Gln Asp Gly Pro Val Thr Val Asn Thr 
                165                 170                 175     


Ser Asp Phe Leu Val Leu Asp Ala Gln Asn Tyr Pro Trp Leu Thr Asn 
            180                 185                 190         


His Thr Val Gln Leu Gln Leu Arg Ser Leu Ala His Asn Leu Ser Val 
        195                 200                 205             


Val Ala Thr Asn Asp Val Gly Val Thr Ser Ala Ser Leu Pro Ala Pro 
    210                 215                 220                 


Gly Pro Ser Arg His Pro Ser Leu Ile Ser Ser Asp Ser Asn Asn Leu 
225                 230                 235                 240 


Lys Leu Asn Asn Val Arg Leu Pro Arg Glu Asn Met Ser Leu Pro Ser 
                245                 250                 255     


Asn Leu Gln Leu Asn Asp Leu Thr Pro Asp Ser Arg Ala Val Lys Pro 
            260                 265                 270         


Ala Asp Arg Gln Met Ala Gln Asn Asn Ser Arg Pro Glu Leu Leu Asp 
        275                 280                 285             


Pro Glu Pro Gly Gly Leu Leu Thr Ser Gln Gly Phe Ile Arg Leu Pro 
    290                 295                 300                 


Val Leu Gly Tyr Ile Tyr Arg Val Ser Ser Val Ser Ser Asp Glu Ile 
305                 310                 315                 320 


Trp Leu 
        


<210>  1762
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  1762

Met Ala Leu Pro Pro Gly Pro Ala Ala Leu Arg His Thr Leu Leu Leu 
1               5                   10                  15      


Leu Pro Ala Leu Leu Ser Ser Gly Trp Gly Glu Leu Glu Pro Gln Ile 
            20                  25                  30          


Asp Gly Gln Thr Trp Ala Glu Arg Ala Leu Arg Glu Asn Glu Arg His 
        35                  40                  45              


Ala Phe Thr Cys Arg Val Ala Gly Gly Pro Gly Thr Pro Arg Leu Ala 
    50                  55                  60                  


Trp Tyr Leu Asp Gly Gln Leu Gln Glu Ala Ser Thr Ser Arg Leu Leu 
65                  70                  75                  80  


Ser Val Gly Gly Glu Ala Phe Ser Gly Gly Thr Ser Thr Phe Thr Val 
                85                  90                  95      


Thr Ala His Arg Ala Gln His Glu Leu Asn Cys Ser Leu Gln Asp Pro 
            100                 105                 110         


Arg Ser Gly Arg Ser Ala Asn Ala Ser Val Ile Leu Asn Val Gln Phe 
        115                 120                 125             


Lys Pro Glu Ile Ala Gln Val Gly Ala Lys Tyr Gln Glu Ala Gln Gly 
    130                 135                 140                 


Pro Gly Leu Leu Val Val Leu Phe Ala Leu Val Arg Ala Asn Pro Pro 
145                 150                 155                 160 


Ala Asn Val Thr Trp Ile Asp Gln Asp Gly Pro Val Thr Val Asn Thr 
                165                 170                 175     


Ser Asp Phe Leu Val Leu Asp Ala Gln Asn Tyr Pro Trp Leu Thr Asn 
            180                 185                 190         


His Thr Val Gln Leu Gln Leu Arg Ser Leu Ala His Asn Leu Ser Val 
        195                 200                 205             


Val Ala Thr Asn Asp Val Gly Val Thr Ser Ala Ser Leu Pro Ala Pro 
    210                 215                 220                 


Gly Pro Ser Arg His Pro Ser Leu Ile Ser Ser Asp Ser Asn Asn Leu 
225                 230                 235                 240 


Lys Leu Asn Asn Val Arg Leu Pro Arg Glu Asn Met Ser Leu Pro Ser 
                245                 250                 255     


Asn Leu Gln Leu Asn Asp Leu Thr Pro Asp Ser Arg Ala Val Lys Pro 
            260                 265                 270         


Ala Asp Arg Gln Met Ala Gln Asn Asn Ser Arg Pro Glu Leu Leu Asp 
        275                 280                 285             


Pro Glu Pro Gly Gly Leu Leu Thr Ser Gln Gly Phe Ile Arg Leu Pro 
    290                 295                 300                 


Val Leu Gly Tyr Ile Tyr Arg Val Ser Ser Val Ser Ser Asp Glu Ile 
305                 310                 315                 320 


Trp Leu 
        


<210>  1763
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  1763

Met Ala Leu Pro Pro Gly Pro Ala Ala Leu Arg His Thr Leu Leu Leu 
1               5                   10                  15      


Leu Pro Ala Leu Leu Ser Ser Val Lys Pro Glu Ile Ala Gln Val Gly 
            20                  25                  30          


Ala Lys Tyr Gln Glu Ala Gln Gly Pro Gly Leu Leu Val Val Leu Phe 
        35                  40                  45              


Ala Leu Val Arg Ala Asn Pro Pro Ala Asn Val Thr Trp Ile Asp Gln 
    50                  55                  60                  


Asp Gly Pro Val Thr Val Asn Thr Ser Asp Phe Leu Val Leu Asp Ala 
65                  70                  75                  80  


Gln Asn Tyr Pro Trp Leu Thr Asn His Thr Val Gln Leu Gln Leu Arg 
                85                  90                  95      


Ser Leu Ala His Asn Leu Ser Val Val Ala Thr Asn Asp Val Gly Val 
            100                 105                 110         


Thr Ser Ala Ser Leu Pro Ala Pro Gly Pro Ser Arg His Pro Ser Leu 
        115                 120                 125             


Ile Ser Ser Asp Ser Asn Asn Leu Lys Leu Asn Asn Val Arg Leu Pro 
    130                 135                 140                 


Arg Glu Asn Met Ser Leu Pro Ser Asn Leu Gln Leu Asn Asp Leu Thr 
145                 150                 155                 160 


Pro Asp Ser Arg Ala Val Lys Pro Ala Asp Arg Gln Met Ala Gln Asn 
                165                 170                 175     


Asn Ser Arg Pro Glu Leu Leu Asp Pro Glu Pro Gly Gly Leu Leu Thr 
            180                 185                 190         


Ser Gln Gly Phe Ile Arg Leu Pro Val Leu Gly Tyr Ile Tyr Arg Val 
        195                 200                 205             


Ser Ser Val Ser Ser Asp Glu Ile Trp Leu 
    210                 215             


<210>  1764
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  1764

Met Ala Leu Pro Pro Gly Pro Ala Ala Leu Arg His Thr Leu Leu Leu 
1               5                   10                  15      


Leu Pro Ala Leu Leu Ser Ser Gly Trp Gly Glu Leu Glu Pro Gln Ile 
            20                  25                  30          


Asp Gly Gln Thr Trp Ala Glu Arg Ala Leu Arg Glu Asn Glu Arg His 
        35                  40                  45              


Ala Phe Thr Cys Arg Val Ala Gly Gly Pro Gly Thr Pro Arg Leu Ala 
    50                  55                  60                  


Trp Tyr Leu Asp Gly Gln Leu Gln Glu Ala Ser Thr Ser Arg Leu Leu 
65                  70                  75                  80  


Ser Val Gly Gly Glu Ala Phe Ser Gly Gly Thr Ser Thr Phe Thr Val 
                85                  90                  95      


Thr Ala His Arg Ala Gln His Glu Leu Asn Cys Ser Leu Gln Asp Pro 
            100                 105                 110         


Arg Ser Gly Arg Ser Ala Asn Ala Ser Val Ile Leu Asn Val Gln Phe 
        115                 120                 125             


Lys Pro Glu Ile Ala Gln Val Gly Ala Lys Tyr Gln Glu Ala Gln Gly 
    130                 135                 140                 


Pro Gly Leu Leu Val Val Leu Phe Ala Leu Val Arg Ala Asn Pro Pro 
145                 150                 155                 160 


Ala Asn Val Thr Trp Ile Asp Gln Asp Gly Pro Val Thr Val Asn Thr 
                165                 170                 175     


Ser Asp Phe Leu Val Leu Asp Ala Gln Asn Tyr Pro Trp Leu Thr Asn 
            180                 185                 190         


His Thr Val Gln Leu Gln Leu Arg Ser Leu Ala His Asn Leu Ser Val 
        195                 200                 205             


Val Ala Thr Asn Asp Val Gly Val Thr Ser Ala Ser Leu Pro Ala Pro 
    210                 215                 220                 


Gly Leu Leu Ala Thr Arg Val Glu Val Pro Leu Leu Gly Ile Val Val 
225                 230                 235                 240 


Ala Ala Gly Leu Ala Leu Gly Thr Leu Val Gly Phe Ser Thr Leu Val 
                245                 250                 255     


Ala Cys Leu Val Cys Arg Lys Glu Lys Lys Thr Lys Gly Pro Ser Arg 
            260                 265                 270         


His Pro Ser Leu Ile Ser Ser Asp Ser Asn Asn Leu Lys Leu Asn Asn 
        275                 280                 285             


Val Arg Leu Pro Arg Glu Asn Met Ser Leu Pro Ser Asn Leu Gln Leu 
    290                 295                 300                 


Asn Asp Leu Thr Pro Asp Ser Arg Ala Val Lys Pro Ala Asp Arg Gln 
305                 310                 315                 320 


Met Ala Gln Asn Asn Ser Arg Pro Glu Leu Leu Asp Pro Glu Pro Gly 
                325                 330                 335     


Gly Leu Leu Thr Ser Gln Gly Arg Arg Asn Gln Asp Lys Asp Ala 
            340                 345                 350     


<210>  1765
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  1765

Met Ala Leu Pro Pro Gly Pro Ala Ala Leu Arg His Thr Leu Leu Leu 
1               5                   10                  15      


Leu Pro Ala Leu Leu Ser Ser Gly Trp Gly Glu Leu Glu Pro Gln Ile 
            20                  25                  30          


Asp Gly Gln Thr Trp Ala Glu Arg Ala Leu Arg Glu Asn Glu Arg His 
        35                  40                  45              


Ala Phe Thr Cys Arg Val Ala Gly Gly Pro Gly Thr Pro Arg Leu Ala 
    50                  55                  60                  


Trp Tyr Leu Asp Gly Gln Leu Gln Glu Ala Ser Thr Ser Arg Leu Leu 
65                  70                  75                  80  


Ser Val Gly Gly Glu Ala Phe Ser Gly Gly Thr Ser Thr Phe Thr Val 
                85                  90                  95      


Thr Ala His Arg Ala Gln His Glu Leu Asn Cys Ser Leu Gln Asp Pro 
            100                 105                 110         


Arg Ser Gly Arg Ser Ala Asn Ala Ser Val Ile Leu Asn Val Gln Phe 
        115                 120                 125             


Lys Pro Glu Ile Ala Gln Val Gly Ala Lys Tyr Gln Glu Ala Gln Gly 
    130                 135                 140                 


Pro Gly Leu Leu Val Val Leu Phe Ala Leu Val Arg Ala Asn Pro Pro 
145                 150                 155                 160 


Ala Asn Val Thr Trp Ile Asp Gln Asp Gly Pro Val Thr Val Asn Thr 
                165                 170                 175     


Ser Asp Phe Leu Val Leu Asp Ala Gln Asn Tyr Pro Trp Leu Thr Asn 
            180                 185                 190         


His Thr Val Gln Leu Gln Leu Arg Ser Leu Ala His Asn Leu Ser Val 
        195                 200                 205             


Val Ala Thr Asn Asp Val Gly Val Thr Ser Ala Ser Leu Pro Ala Pro 
    210                 215                 220                 


Gly Pro Ser Arg His Pro Ser Leu Ile Ser Ser Asp Ser Asn Asn Leu 
225                 230                 235                 240 


Lys Leu Asn Asn Val Arg Leu Pro Arg Glu Asn Met Ser Leu Pro Ser 
                245                 250                 255     


Asn Leu Gln Leu Asn Asp Leu Thr Pro Asp Ser Arg Val Lys Pro Ala 
            260                 265                 270         


Asp Arg Gln Met Ala Gln Asn Asn Ser Arg Pro Glu Leu Leu Asp Pro 
        275                 280                 285             


Glu Pro Gly Gly Leu Leu Thr Ser Gln Gly Arg Arg Asn Gln Asp Lys 
    290                 295                 300                 


Asp Ala 
305     


<210>  1766
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  1766

Met Gly Val Cys Gly Tyr Leu Phe Leu Pro Trp Lys Cys Leu Val Val 
1               5                   10                  15      


Val Ser Leu Arg Leu Leu Phe Leu Val Pro Thr Gly Val Pro Val Arg 
            20                  25                  30          


Ser Gly Asp Ala Thr Phe Pro Lys Ala Met Asp Asn Val Thr Val Arg 
        35                  40                  45              


Gln Gly Glu Ser Ala Thr Leu Arg Cys Thr Ile Asp Asn Arg Val Thr 
    50                  55                  60                  


Arg Val Ala Trp Leu Asn Arg Ser Thr Ile Leu Tyr Ala Gly Asn Asp 
65                  70                  75                  80  


Lys Trp Cys Leu Asp Pro Arg Val Val Leu Leu Ser Asn Thr Gln Thr 
                85                  90                  95      


Gln Tyr Ser Ile Glu Ile Gln Asn Val Asp Val Tyr Asp Glu Gly Pro 
            100                 105                 110         


Tyr Thr Cys Ser Val Gln Thr Asp Asn His Pro Lys Thr Ser Arg Val 
        115                 120                 125             


His Leu Ile Val Gln Val Ser Pro Lys Ile Val Glu Ile Ser Ser Asp 
    130                 135                 140                 


Ile Ser Ile Asn Glu Gly Asn Asn Ile Ser Leu Thr Cys Ile Ala Thr 
145                 150                 155                 160 


Gly Arg Pro Glu Pro Thr Val Thr Trp Arg His Ile Ser Pro Lys Ala 
                165                 170                 175     


Val Gly Phe Val Ser Glu Asp Glu Tyr Leu Glu Ile Gln Gly Ile Thr 
            180                 185                 190         


Arg Glu Gln Ser Gly Asp Tyr Glu Cys Ser Ala Ser Asn Asp Val Ala 
        195                 200                 205             


Ala Pro Val Val Arg Arg Val Lys Val Thr Val Asn Tyr Pro Pro Tyr 
    210                 215                 220                 


Ile Ser Glu Ala Lys Gly Thr Gly Val Pro Val Gly Gln Lys Gly Thr 
225                 230                 235                 240 


Leu Gln Cys Glu Ala Ser Ala Val Pro Ser Ala Glu Phe Gln Trp Tyr 
                245                 250                 255     


Lys Asp Asp Lys Arg Leu Ile Glu Gly Lys Lys Gly Val Lys Val Glu 
            260                 265                 270         


Asn Arg Pro Phe Leu Ser Lys Leu Ile Phe Phe Asn Val Ser Glu His 
        275                 280                 285             


Asp Tyr Gly Asn Tyr Thr Cys Val Ala Ser Asn Lys Leu Gly His Thr 
    290                 295                 300                 


Asn Ala Ser Ile Met Leu Phe Glu Val Lys Thr Thr Ala Leu Thr Pro 
305                 310                 315                 320 


Trp Lys Gly Pro Gly Ala Val Ser Glu Val Ser Asn Gly Thr Ser Arg 
                325                 330                 335     


Arg Ala Gly Cys Val Trp Leu Leu Pro Leu Leu Val Leu His Leu Leu 
            340                 345                 350         


Leu Lys Phe 
        355 


<210>  1767
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  1767

Met Gly Val Cys Gly Tyr Leu Phe Leu Pro Trp Lys Cys Leu Val Val 
1               5                   10                  15      


Val Ser Leu Arg Leu Leu Phe Leu Val Pro Thr Gly Val Pro Val Arg 
            20                  25                  30          


Ser Gly Asp Ala Thr Phe Pro Lys Ala Met Asp Asn Val Thr Val Arg 
        35                  40                  45              


Gln Gly Glu Ser Ala Thr Leu Arg Cys Thr Ile Asp Asn Arg Val Thr 
    50                  55                  60                  


Arg Val Ala Trp Leu Asn Arg Ser Thr Ile Leu Tyr Ala Gly Asn Asp 
65                  70                  75                  80  


Lys Trp Cys Leu Asp Pro Arg Val Val Leu Leu Ser Asn Thr Gln Thr 
                85                  90                  95      


Gln Tyr Ser Ile Glu Ile Gln Asn Val Asp Val Tyr Asp Glu Gly Pro 
            100                 105                 110         


Tyr Thr Cys Ser Val Gln Thr Asp Asn His Pro Lys Thr Ser Arg Val 
        115                 120                 125             


His Leu Ile Val Gln Val Ser Pro Lys Ile Val Glu Ile Ser Ser Asp 
    130                 135                 140                 


Ile Ser Ile Asn Glu Gly Asn Asn Ile Ser Leu Thr Cys Ile Ala Thr 
145                 150                 155                 160 


Gly Arg Pro Glu Pro Thr Val Thr Trp Arg His Ile Ser Pro Lys Ala 
                165                 170                 175     


Val Gly Phe Val Ser Glu Asp Glu Tyr Leu Glu Ile Gln Gly Ile Thr 
            180                 185                 190         


Arg Glu Gln Ser Gly Asp Tyr Glu Cys Ser Ala Ser Asn Asp Val Ala 
        195                 200                 205             


Ala Pro Val Val Arg Arg Val Lys Val Thr Val Asn Tyr Pro Pro Tyr 
    210                 215                 220                 


Ile Ser Glu Ala Lys Gly Thr Gly Val Pro Val Gly Gln Lys Gly Thr 
225                 230                 235                 240 


Leu Gln Cys Glu Ala Ser Ala Val Pro Ser Ala Glu Phe Gln Trp Tyr 
                245                 250                 255     


Lys Asp Asp Lys Arg Leu Ile Glu Gly Lys Lys Gly Val Lys Val Glu 
            260                 265                 270         


Asn Arg Pro Phe Leu Ser Lys Leu Ile Phe Phe Asn Val Ser Glu His 
        275                 280                 285             


Asp Tyr Gly Asn Tyr Thr Cys Val Ala Ser Asn Lys Leu Gly His Thr 
    290                 295                 300                 


Asn Ala Ser Ile Met Leu Phe Gly Glu Thr Val Leu 
305                 310                 315     


<210>  1768
<211>  572
<212>  PRT
<213>  Homo sapiens

<400>  1768

Met Asp Ala Leu Cys Gly Ser Gly Glu Leu Gly Ser Lys Phe Trp Asp 
1               5                   10                  15      


Ser Asn Leu Ser Val His Thr Glu Asn Pro Asp Leu Thr Pro Cys Phe 
            20                  25                  30          


Gln Asn Ser Leu Leu Ala Trp Val Pro Cys Ile Tyr Leu Trp Val Ala 
        35                  40                  45              


Leu Pro Cys Tyr Leu Leu Tyr Leu Arg His His Cys Arg Gly Tyr Ile 
    50                  55                  60                  


Ile Leu Ser His Leu Ser Lys Leu Lys Met Val Leu Gly Val Leu Leu 
65                  70                  75                  80  


Trp Cys Val Ser Trp Ala Asp Leu Phe Tyr Ser Phe His Gly Leu Val 
                85                  90                  95      


His Gly Arg Ala Pro Ala Pro Val Phe Phe Val Thr Pro Leu Val Val 
            100                 105                 110         


Gly Val Thr Met Leu Leu Ala Thr Leu Leu Ile Gln Tyr Glu Arg Leu 
        115                 120                 125             


Gln Gly Val Gln Ser Ser Gly Val Leu Ile Ile Phe Trp Phe Leu Cys 
    130                 135                 140                 


Val Val Cys Ala Ile Val Pro Phe Arg Ser Lys Ile Leu Leu Ala Lys 
145                 150                 155                 160 


Ala Glu Gly Glu Ile Ser Asp Pro Phe Arg Phe Thr Thr Phe Tyr Ile 
                165                 170                 175     


His Phe Ala Leu Val Leu Ser Ala Leu Ile Leu Ala Cys Phe Arg Glu 
            180                 185                 190         


Lys Pro Pro Phe Phe Ser Ala Lys Asn Val Asp Pro Asn Pro Tyr Pro 
        195                 200                 205             


Glu Thr Ser Ala Gly Phe Leu Ser Arg Leu Phe Phe Trp Trp Phe Thr 
    210                 215                 220                 


Lys Met Ala Ile Tyr Gly Tyr Arg His Pro Leu Glu Glu Lys Asp Leu 
225                 230                 235                 240 


Trp Ser Leu Lys Glu Glu Asp Arg Ser Gln Met Val Val Gln Gln Leu 
                245                 250                 255     


Leu Glu Ala Trp Arg Lys Gln Glu Lys Gln Thr Ala Arg His Lys Ala 
            260                 265                 270         


Ser Ala Ala Pro Gly Lys Asn Ala Ser Gly Glu Asp Glu Val Leu Leu 
        275                 280                 285             


Gly Ala Arg Pro Arg Pro Arg Lys Pro Ser Phe Leu Lys Ala Leu Leu 
    290                 295                 300                 


Ala Thr Phe Gly Ser Ser Phe Leu Ile Ser Ala Cys Phe Lys Leu Ile 
305                 310                 315                 320 


Gln Asp Leu Leu Ser Phe Ile Asn Pro Gln Leu Leu Ser Ile Leu Ile 
                325                 330                 335     


Arg Phe Ile Ser Asn Pro Met Ala Pro Ser Trp Trp Gly Phe Leu Val 
            340                 345                 350         


Ala Gly Leu Met Phe Leu Cys Ser Met Met Gln Ser Leu Ile Leu Gln 
        355                 360                 365             


His Tyr Tyr His Tyr Ile Phe Val Thr Gly Val Lys Phe Arg Thr Gly 
    370                 375                 380                 


Ile Met Gly Val Ile Tyr Arg Lys Ala Leu Val Ile Thr Asn Ser Val 
385                 390                 395                 400 


Lys Arg Ala Ser Thr Val Gly Glu Ile Val Asn Leu Met Ser Val Asp 
                405                 410                 415     


Ala Gln Arg Phe Met Asp Leu Ala Pro Phe Leu Asn Leu Leu Trp Ser 
            420                 425                 430         


Ala Pro Leu Gln Ile Ile Leu Ala Ile Tyr Phe Leu Trp Gln Asn Leu 
        435                 440                 445             


Gly Pro Ser Val Leu Ala Gly Val Ala Phe Met Val Leu Leu Ile Pro 
    450                 455                 460                 


Leu Asn Gly Ala Val Ala Val Lys Met Arg Ala Phe Gln Val Lys Gln 
465                 470                 475                 480 


Met Lys Leu Lys Asp Ser Arg Ile Lys Leu Met Ser Glu Ile Leu Asn 
                485                 490                 495     


Gly Ile Lys Val Leu Lys Leu Tyr Ala Trp Glu Pro Ser Phe Leu Lys 
            500                 505                 510         


Gln Val Glu Gly Ile Arg Gln Gly Glu Leu Gln Leu Leu Arg Thr Ala 
        515                 520                 525             


Ala Tyr Leu His Thr Thr Thr Thr Phe Thr Trp Met Cys Ser Pro Phe 
    530                 535                 540                 


Leu Val Arg Leu Gly Thr Gly Leu Gly Pro Cys Leu Gln Gly Ser Gly 
545                 550                 555                 560 


Cys Pro Gly Met Ala Arg Ala His Trp Thr Leu Pro 
                565                 570         


<210>  1769
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  1769

Met Phe Thr Ser Thr Gly Ser Ser Gly Leu Tyr Lys Ala Pro Leu Ser 
1               5                   10                  15      


Lys Ser Leu Leu Leu Val Pro Ser Ala Leu Ser Leu Leu Leu Ala Leu 
            20                  25                  30          


Leu Leu Pro His Cys Gln Lys Leu Phe Val Tyr Asp Leu His Ala Val 
        35                  40                  45              


Lys Asn Asp Phe Gln Ile Trp Arg Leu Ile Cys Gly Arg Ile Ile Cys 
    50                  55                  60                  


Leu Asp Leu Lys Asp Thr Phe Cys Ser Ser Leu Leu Ile Tyr Asn Phe 
65                  70                  75                  80  


Arg Ile Phe Glu Arg Arg Tyr Gly Ser Arg Lys Phe Ala Ser Phe Leu 
                85                  90                  95      


Leu Gly Ser Trp Val Leu Ser Ala Leu Phe Asp Phe Leu Leu Ile Glu 
            100                 105                 110         


Ala Met Gln Tyr Phe Phe Gly Ile Thr Ala Ala Ser Asn Leu Pro Ser 
        115                 120                 125             


Gly Phe Leu Ala Pro Val Phe Ala Leu Phe Val Pro Phe Tyr Cys Ser 
    130                 135                 140                 


Ile Pro Arg Val Gln Val Ala Gln Ile Leu Gly Pro Leu Ser Ile Thr 
145                 150                 155                 160 


Asn Lys Thr Leu Ile Tyr Ile Leu Gly Leu Gln Leu Phe Thr Ser Gly 
                165                 170                 175     


Ser Tyr Ile Trp Ile Val Ala Ile Ser Gly Leu Met Ser Gly Leu Cys 
            180                 185                 190         


Tyr Asp Ser Lys Met Phe Gln Val His Gln Val Leu Cys Ile Pro Ser 
        195                 200                 205             


Trp Met Ala Lys Phe Phe Ser Trp Thr Leu Glu Pro Ile Phe Ser Ser 
    210                 215                 220                 


Ser Glu Pro Thr Ser Glu Ala Arg Ile Gly Met Gly Ala Thr Leu Asp 
225                 230                 235                 240 


Ile Gln Arg Gln Gln Arg Met Glu Leu Leu Asp Arg Gln Leu Met Phe 
                245                 250                 255     


Ser Gln Phe Ala Gln Gly Arg Arg Gln Arg Gln Gln Gln Gly Gly Met 
            260                 265                 270         


Ile Asn Trp Asn Arg Leu Phe Pro Pro Leu Arg Gln Arg Gln Asn Val 
        275                 280                 285             


Asn Tyr Gln Gly Gly Arg Gln Ser Glu Pro Ala Ala Pro Pro Leu Glu 
    290                 295                 300                 


Val Ser Glu Glu Gln Val Ala Arg Leu Met Glu Met Gly Phe Ser Arg 
305                 310                 315                 320 


Gly Asp Ala Leu Glu Ala Leu Arg Ala Ser Asn Asn Asp Leu Asn Val 
                325                 330                 335     


Ala Thr Asn Phe Leu Leu Gln His 
            340                 


<210>  1770
<211>  832
<212>  PRT
<213>  Homo sapiens

<400>  1770

Met Ile Leu Gln Ala His Leu His Ser Leu Cys Leu Leu Met Leu Tyr 
1               5                   10                  15      


Leu Ala Thr Gly Tyr Gly Gln Glu Gly Lys Phe Ser Gly Pro Leu Lys 
            20                  25                  30          


Pro Met Thr Phe Ser Ile Tyr Glu Gly Gln Glu Pro Ser Gln Ile Ile 
        35                  40                  45              


Phe Gln Phe Lys Ala Asn Pro Pro Ala Val Thr Phe Glu Leu Thr Gly 
    50                  55                  60                  


Glu Thr Asp Asn Ile Phe Val Ile Glu Arg Glu Gly Leu Leu Tyr Tyr 
65                  70                  75                  80  


Asn Arg Ala Leu Asp Arg Glu Thr Arg Ser Thr His Asn Leu Gln Val 
                85                  90                  95      


Ala Ala Leu Asp Ala Asn Gly Ile Ile Val Glu Gly Pro Val Pro Ile 
            100                 105                 110         


Thr Ile Lys Val Lys Asp Ile Asn Asp Asn Arg Pro Thr Phe Leu Gln 
        115                 120                 125             


Ser Lys Tyr Glu Gly Ser Val Arg Gln Asn Ser Arg Pro Gly Lys Pro 
    130                 135                 140                 


Phe Leu Tyr Val Asn Ala Thr Asp Leu Asp Asp Pro Ala Thr Pro Asn 
145                 150                 155                 160 


Gly Gln Leu Tyr Tyr Gln Ile Val Ile Gln Leu Pro Met Ile Asn Asn 
                165                 170                 175     


Val Met Tyr Phe Gln Ile Asn Asn Lys Thr Gly Ala Ile Ser Leu Thr 
            180                 185                 190         


Arg Glu Gly Ser Gln Glu Leu Asn Pro Ala Lys Asn Pro Ser Tyr Asn 
        195                 200                 205             


Leu Val Ile Ser Val Lys Asp Met Gly Gly Gln Ser Glu Asn Ser Phe 
    210                 215                 220                 


Ser Asp Thr Thr Ser Val Asp Ile Ile Val Thr Glu Asn Ile Trp Lys 
225                 230                 235                 240 


Ala Pro Lys Pro Val Glu Met Val Glu Asn Ser Thr Asp Pro His Pro 
                245                 250                 255     


Ile Lys Ile Thr Gln Val Arg Trp Asn Asp Pro Gly Ala Gln Tyr Ser 
            260                 265                 270         


Leu Val Asp Lys Glu Lys Leu Pro Arg Phe Pro Phe Ser Ile Asp Gln 
        275                 280                 285             


Glu Gly Asp Ile Tyr Val Thr Gln Pro Leu Asp Arg Glu Glu Lys Asp 
    290                 295                 300                 


Ala Tyr Val Phe Tyr Ala Val Ala Lys Asp Glu Tyr Gly Lys Pro Leu 
305                 310                 315                 320 


Ser Tyr Pro Leu Glu Ile His Val Lys Val Lys Asp Ile Asn Asp Asn 
                325                 330                 335     


Pro Pro Thr Cys Pro Ser Pro Val Thr Val Phe Glu Val Gln Glu Asn 
            340                 345                 350         


Glu Arg Leu Gly Asn Ser Ile Gly Thr Leu Thr Ala His Asp Arg Asp 
        355                 360                 365             


Glu Glu Asn Thr Ala Asn Ser Phe Leu Asn Tyr Arg Ile Val Glu Gln 
    370                 375                 380                 


Thr Pro Lys Leu Pro Met Asp Gly Leu Phe Leu Ile Gln Thr Tyr Ala 
385                 390                 395                 400 


Gly Met Leu Gln Leu Ala Lys Gln Ser Leu Lys Lys Gln Asp Thr Pro 
                405                 410                 415     


Gln Tyr Asn Leu Thr Ile Glu Val Ser Asp Lys Asp Phe Lys Thr Leu 
            420                 425                 430         


Cys Phe Val Gln Ile Asn Val Ile Asp Ile Asn Asp Gln Ile Pro Ile 
        435                 440                 445             


Phe Glu Lys Ser Asp Tyr Gly Asn Leu Thr Leu Ala Glu Asp Thr Asn 
    450                 455                 460                 


Ile Gly Ser Thr Ile Leu Thr Ile Gln Ala Thr Asp Ala Asp Glu Pro 
465                 470                 475                 480 


Phe Thr Gly Ser Ser Lys Ile Leu Tyr His Ile Ile Lys Gly Asp Ser 
                485                 490                 495     


Glu Gly Arg Leu Gly Val Asp Thr Asp Pro His Thr Asn Thr Gly Tyr 
            500                 505                 510         


Val Ile Ile Lys Lys Pro Leu Asp Phe Glu Thr Ala Ala Val Ser Asn 
        515                 520                 525             


Ile Val Phe Lys Ala Glu Asn Pro Glu Pro Leu Val Phe Gly Val Lys 
    530                 535                 540                 


Tyr Asn Ala Ser Ser Phe Ala Lys Phe Thr Leu Ile Val Thr Asp Val 
545                 550                 555                 560 


Asn Glu Ala Pro Gln Phe Ser Gln His Val Phe Gln Ala Lys Val Ser 
                565                 570                 575     


Glu Asp Val Ala Ile Gly Thr Lys Val Gly Asn Val Thr Ala Lys Asp 
            580                 585                 590         


Pro Glu Gly Leu Asp Ile Ser Tyr Ser Leu Arg Gly Asp Thr Arg Gly 
        595                 600                 605             


Trp Leu Lys Ile Asp His Val Thr Gly Glu Ile Phe Ser Val Ala Pro 
    610                 615                 620                 


Leu Asp Arg Glu Ala Gly Ser Pro Tyr Arg Val Gln Val Val Ala Thr 
625                 630                 635                 640 


Glu Val Gly Gly Ser Ser Leu Ser Ser Val Ser Glu Phe His Leu Ile 
                645                 650                 655     


Leu Met Asp Val Asn Asp Asn Pro Pro Arg Leu Ala Lys Asp Tyr Thr 
            660                 665                 670         


Gly Leu Phe Phe Cys His Pro Leu Ser Ala Pro Gly Ser Leu Ile Phe 
        675                 680                 685             


Glu Ala Thr Asp Asp Asp Gln His Leu Phe Arg Gly Pro His Phe Thr 
    690                 695                 700                 


Phe Ser Leu Gly Ser Gly Ser Leu Gln Asn Asp Trp Glu Val Ser Lys 
705                 710                 715                 720 


Ile Asn Gly Thr His Ala Arg Leu Ser Thr Arg His Thr Glu Phe Glu 
                725                 730                 735     


Glu Arg Glu Tyr Val Val Leu Ile Arg Ile Asn Asp Gly Gly Arg Pro 
            740                 745                 750         


Pro Leu Glu Gly Ile Val Ser Leu Pro Val Thr Phe Cys Ser Cys Val 
        755                 760                 765             


Glu Gly Ser Cys Phe Arg Pro Ala Gly His Gln Thr Gly Ile Pro Thr 
    770                 775                 780                 


Val Gly Met Ala Val Gly Ile Leu Leu Thr Thr Leu Leu Val Ile Gly 
785                 790                 795                 800 


Ile Ile Leu Ala Val Val Phe Ile Arg Ile Lys Lys Asp Lys Gly Lys 
                805                 810                 815     


Asp Asn Val Glu Ser Ala Gln Ala Ser Glu Val Lys Pro Leu Arg Ser 
            820                 825                 830         


<210>  1771
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  1771

Met Phe Ile Met Asn Glu Lys Trp Asp Thr Asn Ser Ser Glu Asn Trp 
1               5                   10                  15      


His Pro Ile Trp Asn Val Asn Asp Thr Lys His His Leu Tyr Ser Asp 
            20                  25                  30          


Ile Asn Ile Thr Tyr Val Asn Tyr Tyr Leu His Gln Pro Gln Val Ala 
        35                  40                  45              


Ala Ile Phe Ile Ile Ser Tyr Phe Leu Ile Phe Phe Leu Cys Met Met 
    50                  55                  60                  


Gly Asn Thr Val Val Cys Phe Ile Val Met Arg Asn Lys His Met His 
65                  70                  75                  80  


Thr Val Thr Asn Leu Phe Ile Leu Asn Leu Ala Ile Ser Asp Leu Leu 
                85                  90                  95      


Val Gly Ile Phe Cys Met Pro Ile Thr Leu Leu Asp Asn Ile Ile Ala 
            100                 105                 110         


Gly Trp Pro Phe Gly Asn Thr Met Cys Lys Ile Ser Gly Leu Val Gln 
        115                 120                 125             


Gly Ile Ser Val Ala Ala Ser Val Phe Thr Leu Val Ala Ile Ala Val 
    130                 135                 140                 


Asp Arg Phe Gln Cys Val Val Tyr Pro Phe Lys Pro Lys Leu Thr Ile 
145                 150                 155                 160 


Lys Thr Ala Phe Val Ile Ile Met Ile Ile Trp Val Leu Ala Ile Thr 
                165                 170                 175     


Ile Met Ser Pro Ser Ala Val Met Leu His Val Gln Glu Glu Lys Tyr 
            180                 185                 190         


Tyr Arg Val Arg Leu Asn Ser Gln Asn Lys Thr Ser Pro Val Tyr Trp 
        195                 200                 205             


Cys Arg Glu Asp Trp Pro Asn Gln Glu Met Arg Lys Ile Tyr Thr Thr 
    210                 215                 220                 


Val Leu Phe Ala Asn Ile Tyr Leu Ala Pro Leu Ser Leu Ile Val Ile 
225                 230                 235                 240 


Met Tyr Gly Arg Ile Gly Ile Ser Leu Phe Arg Ala Ala Val Pro His 
                245                 250                 255     


Thr Gly Arg Lys Asn Gln Glu Gln Trp His Val Val Ser Arg Lys Lys 
            260                 265                 270         


Gln Lys Ile Ile Lys Met Leu Leu Ile Val Ala Leu Leu Phe Ile Leu 
        275                 280                 285             


Ser Trp Leu Pro Leu Trp Thr Leu Met Met Leu Ser Asp Tyr Ala Asp 
    290                 295                 300                 


Leu Ser Pro Asn Glu Leu Gln Ile Ile Asn Ile Tyr Ile Tyr Pro Phe 
305                 310                 315                 320 


Ala His Trp Leu Ala Phe Gly Asn Ser Ser Val Asn Pro Ile Ile Tyr 
                325                 330                 335     


Gly Phe Phe Asn Glu Asn Phe Arg Arg Gly Phe Gln Glu Ala Phe Gln 
            340                 345                 350         


Leu Gln Leu Cys Gln Lys Arg Ala Lys Pro Met Glu Ala Tyr Ala Leu 
        355                 360                 365             


Lys Ala Lys Ser His Val Leu Ile Asn Thr Ser Asn Gln Leu Val Gln 
    370                 375                 380                 


Glu Ser Thr Phe Gln Asn Pro His Gly Glu Thr Leu Leu Tyr Arg Lys 
385                 390                 395                 400 


Ser Ala Glu Lys Pro Gln Gln Glu Leu Val Met Glu Glu Leu Lys Glu 
                405                 410                 415     


Thr Thr Asn Ser Ser Glu Ile 
            420             


<210>  1772
<211>  5675
<212>  PRT
<213>  Homo sapiens

<400>  1772

Met Ile Ala Ala Ala Phe Leu Val Leu Leu Arg Pro Tyr Ser Ile Gln 
1               5                   10                  15      


Cys Ala Leu Phe Leu Leu Leu Leu Leu Leu Gly Thr Ile Ala Thr Ile 
            20                  25                  30          


Val Phe Phe Cys Cys Trp His Arg Lys Leu Gln Lys Gly Arg His Pro 
        35                  40                  45              


Met Lys Ser Val Phe Ser Gly Arg Ser Arg Ser Arg Asp Ala Val Leu 
    50                  55                  60                  


Arg Ser His His Phe Arg Ser Glu Gly Phe Arg Ala Ser Pro Arg His 
65                  70                  75                  80  


Leu Arg Arg Arg Val Ala Ala Ala Ala Ala Ala Arg Leu Glu Glu Val 
                85                  90                  95      


Lys Pro Val Val Glu Val His His Gln Ser Glu Gln Glu Thr Ser Val 
            100                 105                 110         


Arg Lys Arg Arg Ile Lys Lys Ser Ser Arg Val Gln Pro Glu Phe Tyr 
        115                 120                 125             


His Ser Val Gln Gly Ala Ser Ile Arg Arg Pro Ser Ser Gly Asn Ala 
    130                 135                 140                 


Ser Tyr Arg Cys Ser Met Ser Ser Ser Ala Asp Phe Ser Asp Glu Asp 
145                 150                 155                 160 


Asp Phe Ser Gln Lys Ser Gly Ser Ala Ser Pro Ala Pro Gly Asp Thr 
                165                 170                 175     


Leu Pro Trp Asn Leu Pro Lys His Glu Arg Ser Lys Arg Lys Ile Gln 
            180                 185                 190         


Gly Gly Ser Val Leu Asp Pro Ala Glu Arg Ala Val Leu Arg Ile Ala 
        195                 200                 205             


Asp Glu Arg Asp Lys Val Gln Lys Lys Thr Phe Thr Lys Trp Ile Asn 
    210                 215                 220                 


Gln His Leu Met Lys Val Arg Lys His Val Asn Asp Leu Tyr Glu Asp 
225                 230                 235                 240 


Leu Arg Asp Gly His Asn Leu Ile Ser Leu Leu Glu Val Leu Ser Gly 
                245                 250                 255     


Asp Thr Leu Pro Arg Glu Lys Gly Arg Met Arg Phe His Arg Leu Gln 
            260                 265                 270         


Asn Val Gln Ile Ala Leu Asp Tyr Leu Lys Arg Arg Gln Val Lys Leu 
        275                 280                 285             


Val Asn Ile Arg Asn Asp Asp Ile Thr Asp Gly Asn Pro Lys Leu Thr 
    290                 295                 300                 


Leu Gly Leu Ile Trp Thr Ile Ile Leu His Phe Gln Ile Ser Asp Ile 
305                 310                 315                 320 


His Val Thr Gly Glu Ser Glu Asp Met Ser Ala Lys Glu Arg Leu Leu 
                325                 330                 335     


Leu Trp Thr Gln Gln Ala Thr Glu Gly Tyr Ala Gly Ile Arg Cys Glu 
            340                 345                 350         


Asn Phe Thr Thr Cys Trp Arg Asp Gly Lys Leu Phe Asn Ala Ile Ile 
        355                 360                 365             


His Lys Tyr Arg Pro Asp Leu Ile Asp Met Asn Thr Val Ala Val Gln 
    370                 375                 380                 


Ser Asn Leu Ala Asn Leu Glu His Ala Phe Tyr Val Ala Glu Lys Ile 
385                 390                 395                 400 


Gly Val Ile Arg Leu Leu Asp Pro Glu Asp Val Asp Val Ser Ser Pro 
                405                 410                 415     


Asp Glu Lys Ser Val Ile Thr Tyr Val Ser Ser Leu Tyr Asp Ala Phe 
            420                 425                 430         


Pro Lys Val Pro Glu Gly Gly Glu Gly Ile Gly Ala Asn Asp Val Glu 
        435                 440                 445             


Val Lys Trp Ile Glu Tyr Gln Asn Met Val Asn Tyr Leu Ile Gln Trp 
    450                 455                 460                 


Ile Arg His His Val Thr Thr Met Ser Glu Arg Thr Phe Pro Asn Asn 
465                 470                 475                 480 


Pro Val Glu Leu Lys Ala Leu Tyr Asn Gln Tyr Leu Gln Phe Lys Glu 
                485                 490                 495     


Thr Glu Ile Pro Pro Lys Glu Thr Glu Lys Ser Lys Ile Lys Arg Leu 
            500                 505                 510         


Tyr Lys Leu Leu Glu Ile Trp Ile Glu Phe Gly Arg Ile Lys Leu Leu 
        515                 520                 525             


Gln Gly Tyr His Pro Asn Asp Ile Glu Lys Glu Trp Gly Lys Leu Ile 
    530                 535                 540                 


Ile Ala Met Leu Glu Arg Glu Lys Ala Leu Arg Pro Glu Val Glu Arg 
545                 550                 555                 560 


Leu Glu Met Leu Gln Gln Ile Ala Asn Arg Val Gln Arg Asp Ser Val 
                565                 570                 575     


Ile Cys Glu Asp Lys Leu Ile Leu Ala Gly Asn Ala Leu Gln Ser Asp 
            580                 585                 590         


Ser Lys Arg Leu Glu Ser Gly Val Gln Phe Gln Asn Glu Ala Glu Ile 
        595                 600                 605             


Ala Gly Tyr Ile Leu Glu Cys Glu Asn Leu Leu Arg Gln His Val Ile 
    610                 615                 620                 


Asp Val Gln Ile Leu Ile Asp Gly Lys Tyr Tyr Gln Ala Asp Gln Leu 
625                 630                 635                 640 


Val Gln Arg Val Ala Lys Leu Arg Asp Glu Ile Met Ala Leu Arg Asn 
                645                 650                 655     


Glu Cys Ser Ser Val Tyr Ser Lys Gly Arg Ile Leu Thr Thr Glu Gln 
            660                 665                 670         


Thr Lys Leu Met Ile Ser Gly Ile Thr Gln Ser Leu Asn Ser Gly Phe 
        675                 680                 685             


Ala Gln Thr Leu His Pro Ser Leu Thr Ser Gly Leu Thr Gln Ser Leu 
    690                 695                 700                 


Thr Pro Ser Leu Thr Ser Ser Ser Met Thr Ser Gly Leu Ser Ser Gly 
705                 710                 715                 720 


Met Thr Ser Arg Leu Thr Pro Ser Val Thr Pro Ala Tyr Thr Pro Gly 
                725                 730                 735     


Phe Pro Ser Gly Leu Val Pro Asn Phe Ser Ser Gly Val Glu Pro Asn 
            740                 745                 750         


Ser Leu Gln Thr Leu Lys Leu Met Gln Ile Arg Lys Pro Leu Leu Lys 
        755                 760                 765             


Ser Ser Leu Leu Asp Gln Asn Leu Thr Glu Glu Glu Ile Asn Met Lys 
    770                 775                 780                 


Phe Val Gln Asp Leu Leu Asn Trp Val Asp Glu Met Gln Val Gln Leu 
785                 790                 795                 800 


Asp Arg Thr Glu Trp Gly Ser Asp Leu Pro Ser Val Glu Ser His Leu 
                805                 810                 815     


Glu Asn His Lys Asn Val His Arg Ala Ile Glu Glu Phe Glu Ser Ser 
            820                 825                 830         


Leu Lys Glu Ala Lys Ile Ser Glu Ile Gln Met Thr Ala Pro Leu Lys 
        835                 840                 845             


Leu Thr Tyr Ala Glu Lys Leu His Arg Leu Glu Ser Gln Tyr Ala Lys 
    850                 855                 860                 


Leu Leu Asn Thr Ser Arg Asn Gln Glu Arg His Leu Asp Thr Leu His 
865                 870                 875                 880 


Asn Phe Val Ser Arg Ala Thr Asn Glu Leu Ile Trp Leu Asn Glu Lys 
                885                 890                 895     


Glu Glu Glu Glu Val Ala Tyr Asp Trp Ser Glu Arg Asn Thr Asn Ile 
            900                 905                 910         


Ala Arg Lys Lys Asp Tyr His Ala Glu Leu Met Arg Glu Leu Asp Gln 
        915                 920                 925             


Lys Glu Glu Asn Ile Lys Ser Val Gln Glu Ile Ala Glu Gln Leu Leu 
    930                 935                 940                 


Leu Glu Asn His Pro Ala Arg Leu Thr Ile Glu Ala Tyr Arg Ala Ala 
945                 950                 955                 960 


Met Gln Thr Gln Trp Ser Trp Ile Leu Gln Leu Cys Gln Cys Val Glu 
                965                 970                 975     


Gln His Ile Lys Glu Asn Thr Ala Tyr Phe Glu Phe Phe Asn Asp Ala 
            980                 985                 990         


Lys Glu Ala Thr Asp Tyr Leu Arg  Asn Leu Lys Asp Ala  Ile Gln Arg 
        995                 1000                 1005             


Lys Tyr  Ser Cys Asp Arg Ser  Ser Ser Ile His Lys  Leu Glu Asp 
    1010                 1015                 1020             


Leu Val  Gln Glu Ser Met Glu  Glu Lys Glu Glu Leu  Leu Gln Tyr 
    1025                 1030                 1035             


Lys Ser  Thr Ile Ala Asn Leu  Met Gly Lys Ala Lys  Thr Ile Ile 
    1040                 1045                 1050             


Gln Leu  Lys Pro Arg Asn Ser  Asp Cys Pro Leu Lys  Thr Ser Ile 
    1055                 1060                 1065             


Pro Ile  Lys Ala Ile Cys Asp  Tyr Arg Gln Ile Glu  Ile Thr Ile 
    1070                 1075                 1080             


Tyr Lys  Asp Asp Glu Cys Val  Leu Ala Asn Asn Ser  His Arg Ala 
    1085                 1090                 1095             


Lys Trp  Lys Val Ile Ser Pro  Thr Gly Asn Glu Ala  Met Val Pro 
    1100                 1105                 1110             


Ser Val  Cys Phe Thr Val Pro  Pro Pro Asn Lys Glu  Ala Val Asp 
    1115                 1120                 1125             


Leu Ala  Asn Arg Ile Glu Gln  Gln Tyr Gln Asn Val  Leu Thr Leu 
    1130                 1135                 1140             


Trp His  Glu Ser His Ile Asn  Met Lys Ser Val Val  Ser Trp His 
    1145                 1150                 1155             


Tyr Leu  Ile Asn Glu Ile Asp  Arg Ile Arg Ala Ser  Asn Val Ala 
    1160                 1165                 1170             


Ser Ile  Lys Thr Met Leu Pro  Gly Glu His Gln Gln  Val Leu Ser 
    1175                 1180                 1185             


Asn Leu  Gln Ser Arg Phe Glu  Asp Phe Leu Glu Asp  Ser Gln Glu 
    1190                 1195                 1200             


Ser Gln  Val Phe Ser Gly Ser  Asp Ile Thr Gln Leu  Glu Lys Glu 
    1205                 1210                 1215             


Val Asn  Val Cys Lys Gln Tyr  Tyr Gln Glu Leu Leu  Lys Ser Ala 
    1220                 1225                 1230             


Glu Arg  Glu Glu Gln Glu Glu  Ser Val Tyr Asn Leu  Tyr Ile Ser 
    1235                 1240                 1245             


Glu Val  Arg Asn Ile Arg Leu  Arg Leu Glu Asn Cys  Glu Asp Arg 
    1250                 1255                 1260             


Leu Ile  Arg Gln Ile Arg Thr  Pro Leu Glu Arg Asp  Asp Leu His 
    1265                 1270                 1275             


Glu Ser  Val Phe Arg Ile Thr  Glu Gln Glu Lys Leu  Lys Lys Glu 
    1280                 1285                 1290             


Leu Glu  Arg Leu Lys Asp Asp  Leu Gly Thr Ile Thr  Asn Lys Cys 
    1295                 1300                 1305             


Glu Glu  Phe Phe Ser Gln Ala  Ala Ala Ser Ser Ser  Val Pro Thr 
    1310                 1315                 1320             


Leu Arg  Ser Glu Leu Asn Val  Val Leu Gln Asn Met  Asn Gln Val 
    1325                 1330                 1335             


Tyr Ser  Met Ser Ser Thr Tyr  Ile Asp Lys Leu Lys  Thr Val Asn 
    1340                 1345                 1350             


Leu Val  Leu Lys Asn Thr Gln  Ala Ala Glu Ala Leu  Val Lys Leu 
    1355                 1360                 1365             


Tyr Glu  Thr Lys Leu Cys Glu  Glu Glu Ala Val Ile  Ala Asp Lys 
    1370                 1375                 1380             


Asn Asn  Ile Glu Asn Leu Ile  Ser Thr Leu Lys Gln  Trp Arg Ser 
    1385                 1390                 1395             


Glu Val  Asp Glu Lys Arg Gln  Val Phe His Ala Leu  Glu Asp Glu 
    1400                 1405                 1410             


Leu Gln  Lys Ala Lys Ala Ile  Ser Asp Glu Met Phe  Lys Thr Tyr 
    1415                 1420                 1425             


Lys Glu  Arg Asp Leu Asp Phe  Asp Trp His Lys Glu  Lys Ala Asp 
    1430                 1435                 1440             


Gln Leu  Val Glu Arg Trp Gln  Asn Val His Val Gln  Ile Asp Asn 
    1445                 1450                 1455             


Arg Leu  Arg Asp Leu Glu Gly  Ile Gly Lys Ser Leu  Lys Tyr Tyr 
    1460                 1465                 1470             


Arg Asp  Thr Tyr His Pro Leu  Asp Asp Trp Ile Gln  Gln Val Glu 
    1475                 1480                 1485             


Thr Thr  Gln Arg Lys Ile Gln  Glu Asn Gln Pro Glu  Asn Ser Lys 
    1490                 1495                 1500             


Thr Leu  Ala Thr Gln Leu Asn  Gln Gln Lys Met Leu  Val Ser Glu 
    1505                 1510                 1515             


Ile Glu  Met Lys Gln Ser Lys  Met Asp Glu Cys Gln  Lys Tyr Ala 
    1520                 1525                 1530             


Glu Gln  Tyr Ser Ala Thr Val  Lys Asp Tyr Glu Leu  Gln Thr Met 
    1535                 1540                 1545             


Thr Tyr  Arg Ala Met Val Asp  Ser Gln Gln Lys Ser  Pro Val Lys 
    1550                 1555                 1560             


Arg Arg  Arg Met Gln Ser Ser  Ala Asp Leu Ile Ile  Gln Glu Phe 
    1565                 1570                 1575             


Met Asp  Leu Arg Thr Arg Tyr  Thr Ala Leu Val Thr  Leu Met Thr 
    1580                 1585                 1590             


Gln Tyr  Ile Lys Phe Ala Gly  Asp Ser Leu Lys Arg  Leu Glu Glu 
    1595                 1600                 1605             


Glu Glu  Lys Ser Leu Glu Glu  Glu Lys Lys Glu His  Val Glu Lys 
    1610                 1615                 1620             


Ala Lys  Glu Leu Gln Lys Trp  Val Ser Asn Ile Ser  Lys Thr Leu 
    1625                 1630                 1635             


Lys Asp  Ala Glu Lys Ala Gly  Lys Pro Pro Phe Ser  Lys Gln Lys 
    1640                 1645                 1650             


Ile Ser  Ser Glu Glu Ile Ser  Thr Lys Lys Glu Gln  Leu Ser Glu 
    1655                 1660                 1665             


Ala Leu  Gln Thr Ile Gln Leu  Phe Leu Ala Lys His  Gly Asp Lys 
    1670                 1675                 1680             


Met Thr  Asp Glu Glu Arg Asn  Glu Leu Glu Lys Gln  Val Lys Thr 
    1685                 1690                 1695             


Leu Gln  Glu Ser Tyr Asn Leu  Leu Phe Ser Glu Ser  Leu Lys Gln 
    1700                 1705                 1710             


Leu Gln  Glu Ser Gln Thr Ser  Gly Asp Val Lys Val  Glu Glu Lys 
    1715                 1720                 1725             


Ile Val  Ala Glu Arg Gln Gln  Glu Tyr Lys Glu Lys  Leu Gln Gly 
    1730                 1735                 1740             


Ile Cys  Asp Leu Leu Thr Gln  Thr Glu Asn Arg Leu  Ile Gly His 
    1745                 1750                 1755             


Gln Glu  Ala Phe Met Ile Gly  Asp Gly Thr Val Glu  Leu Lys Lys 
    1760                 1765                 1770             


Tyr Gln  Ser Lys Gln Glu Glu  Leu Gln Lys Asp Met  Gln Gly Ser 
    1775                 1780                 1785             


Ala Gln  Ala Leu Ala Glu Val  Val Lys Asn Thr Glu  Asn Phe Leu 
    1790                 1795                 1800             


Lys Glu  Asn Gly Glu Lys Leu  Ser Gln Glu Asp Lys  Ala Leu Ile 
    1805                 1810                 1815             


Glu Gln  Lys Leu Asn Glu Ala  Lys Ile Lys Cys Glu  Gln Leu Asn 
    1820                 1825                 1830             


Leu Lys  Ala Glu Gln Ser Lys  Lys Glu Leu Asp Lys  Val Val Thr 
    1835                 1840                 1845             


Thr Ala  Ile Lys Glu Glu Thr  Glu Lys Val Ala Ala  Val Lys Gln 
    1850                 1855                 1860             


Leu Glu  Glu Ser Lys Thr Lys  Ile Glu Asn Leu Leu  Asp Trp Leu 
    1865                 1870                 1875             


Ser Asn  Val Asp Lys Asp Ser  Glu Arg Ala Gly Thr  Lys His Lys 
    1880                 1885                 1890             


Gln Val  Ile Glu Gln Asn Gly  Thr His Phe Gln Glu  Gly Asp Gly 
    1895                 1900                 1905             


Lys Ser  Ala Ile Gly Glu Glu  Asp Glu Val Asn Gly  Asn Leu Leu 
    1910                 1915                 1920             


Glu Thr  Asp Val Asp Gly Gln  Val Gly Thr Thr Gln  Glu Asn Leu 
    1925                 1930                 1935             


Asn Gln  Gln Tyr Gln Lys Val  Lys Ala Gln His Glu  Lys Ile Ile 
    1940                 1945                 1950             


Ser Gln  His Gln Ala Val Ile  Ile Ala Thr Gln Ser  Ala Gln Val 
    1955                 1960                 1965             


Leu Leu  Glu Lys Gln Gly Gln  Tyr Leu Ser Pro Glu  Glu Lys Glu 
    1970                 1975                 1980             


Lys Leu  Gln Lys Asn Met Lys  Glu Leu Lys Val His  Tyr Glu Thr 
    1985                 1990                 1995             


Ala Leu  Ala Glu Ser Glu Lys  Lys Met Lys Leu Thr  His Ser Leu 
    2000                 2005                 2010             


Gln Glu  Glu Leu Glu Lys Phe  Asp Ala Asp Tyr Thr  Glu Phe Glu 
    2015                 2020                 2025             


His Trp  Leu Gln Gln Ser Glu  Gln Glu Leu Glu Asn  Leu Glu Ala 
    2030                 2035                 2040             


Gly Ala  Asp Asp Ile Asn Gly  Leu Met Thr Lys Leu  Lys Arg Gln 
    2045                 2050                 2055             


Lys Ser  Phe Ser Glu Asp Val  Ile Ser His Lys Gly  Asp Leu Arg 
    2060                 2065                 2070             


Tyr Ile  Thr Ile Ser Gly Asn  Arg Val Leu Glu Ala  Ala Lys Ser 
    2075                 2080                 2085             


Cys Ser  Lys Arg Asp Gly Gly  Lys Val Asp Thr Ser  Ala Thr His 
    2090                 2095                 2100             


Arg Glu  Val Gln Arg Lys Leu  Asp His Ala Thr Asp  Arg Phe Arg 
    2105                 2110                 2115             


Ser Leu  Tyr Ser Lys Cys Asn  Val Leu Gly Asn Asn  Leu Lys Asp 
    2120                 2125                 2130             


Leu Val  Asp Lys Tyr Gln His  Tyr Glu Asp Ala Ser  Cys Gly Leu 
    2135                 2140                 2145             


Leu Ala  Gly Leu Gln Ala Cys  Glu Ala Thr Ala Ser  Lys His Leu 
    2150                 2155                 2160             


Ser Glu  Pro Ile Ala Val Asp  Pro Lys Asn Leu Gln  Arg Gln Leu 
    2165                 2170                 2175             


Glu Glu  Thr Lys Ala Leu Gln  Gly Gln Ile Ser Ser  Gln Gln Val 
    2180                 2185                 2190             


Ala Val  Glu Lys Leu Lys Lys  Thr Ala Glu Val Leu  Leu Asp Ala 
    2195                 2200                 2205             


Arg Gly  Ser Leu Leu Pro Ala  Lys Asn Asp Ile Gln  Lys Thr Leu 
    2210                 2215                 2220             


Asp Asp  Ile Val Gly Arg Tyr  Glu Asp Leu Ser Lys  Ser Val Asn 
    2225                 2230                 2235             


Glu Arg  Asn Glu Lys Leu Gln  Ile Thr Leu Thr Arg  Ser Leu Ser 
    2240                 2245                 2250             


Val Gln  Asp Gly Leu Asp Glu  Met Leu Asp Trp Met  Gly Asn Val 
    2255                 2260                 2265             


Glu Ser  Ser Leu Lys Glu Gln  Gly Gln Val Pro Leu  Asn Ser Thr 
    2270                 2275                 2280             


Ala Leu  Gln Asp Ile Ile Ser  Lys Asn Ile Met Leu  Glu Gln Asp 
    2285                 2290                 2295             


Ile Ala  Gly Arg Gln Ser Ser  Ile Asn Ala Met Asn  Glu Lys Val 
    2300                 2305                 2310             


Lys Lys  Phe Met Glu Thr Thr  Asp Pro Ser Thr Ala  Ser Ser Leu 
    2315                 2320                 2325             


Gln Ala  Lys Met Lys Asp Leu  Ser Ala Arg Phe Ser  Glu Ala Ser 
    2330                 2335                 2340             


His Lys  His Lys Glu Thr Leu  Ala Lys Met Glu Glu  Leu Lys Thr 
    2345                 2350                 2355             


Lys Val  Glu Leu Phe Glu Asn  Leu Ser Glu Lys Leu  Gln Thr Phe 
    2360                 2365                 2370             


Leu Glu  Thr Lys Thr Gln Ala  Leu Thr Glu Val Asp  Val Pro Gly 
    2375                 2380                 2385             


Lys Asp  Val Thr Glu Leu Ser  Gln Tyr Met Gln Glu  Ser Thr Ser 
    2390                 2395                 2400             


Glu Phe  Leu Glu His Lys Lys  His Leu Glu Val Leu  His Ser Leu 
    2405                 2410                 2415             


Leu Lys  Glu Ile Ser Ser His  Gly Leu Pro Ser Asp  Lys Ala Leu 
    2420                 2425                 2430             


Val Leu  Glu Lys Thr Asn Asn  Leu Ser Lys Lys Phe  Lys Glu Met 
    2435                 2440                 2445             


Glu Asp  Thr Ile Lys Glu Lys  Lys Glu Ala Val Thr  Ser Cys Gln 
    2450                 2455                 2460             


Glu Gln  Leu Asp Ala Phe Gln  Val Leu Val Lys Ser  Leu Lys Ser 
    2465                 2470                 2475             


Trp Ile  Lys Glu Thr Thr Lys  Lys Val Pro Ile Val  Gln Pro Ser 
    2480                 2485                 2490             


Phe Gly  Ala Glu Asp Leu Gly  Lys Ser Leu Glu Asp  Thr Lys Lys 
    2495                 2500                 2505             


Leu Gln  Glu Lys Trp Ser Leu  Lys Thr Pro Glu Ile  Gln Lys Val 
    2510                 2515                 2520             


Asn Asn  Ser Gly Ile Ser Leu  Cys Asn Leu Ile Ser  Ala Val Thr 
    2525                 2530                 2535             


Thr Pro  Ala Lys Ala Ile Ala  Ala Val Lys Ser Gly  Gly Ala Val 
    2540                 2545                 2550             


Leu Asn  Gly Glu Gly Thr Ala  Thr Asn Thr Glu Glu  Phe Trp Ala 
    2555                 2560                 2565             


Asn Lys  Gly Leu Thr Ser Ile  Lys Lys Asp Met Thr  Asp Ile Ser 
    2570                 2575                 2580             


His Gly  Tyr Glu Asp Leu Gly  Leu Leu Leu Lys Asp  Lys Ile Ala 
    2585                 2590                 2595             


Glu Leu  Asn Thr Lys Leu Ser  Lys Leu Gln Lys Ala  Gln Glu Glu 
    2600                 2605                 2610             


Ser Ser  Ala Met Met Gln Trp  Leu Gln Lys Met Asn  Lys Thr Ala 
    2615                 2620                 2625             


Thr Lys  Trp Gln Gln Thr Pro  Ala Pro Thr Asp Thr  Glu Ala Val 
    2630                 2635                 2640             


Lys Thr  Gln Val Glu Gln Asn  Lys Ser Phe Glu Ala  Glu Leu Lys 
    2645                 2650                 2655             


Gln Asn  Val Asn Lys Val Gln  Glu Leu Lys Asp Lys  Leu Thr Glu 
    2660                 2665                 2670             


Leu Leu  Glu Glu Asn Pro Asp  Thr Pro Glu Ala Pro  Arg Trp Lys 
    2675                 2680                 2685             


Gln Met  Leu Thr Glu Ile Asp  Ser Lys Trp Gln Glu  Leu Asn Gln 
    2690                 2695                 2700             


Leu Thr  Ile Asp Arg Gln Gln  Lys Leu Glu Glu Ser  Ser Asn Asn 
    2705                 2710                 2715             


Leu Thr  Gln Phe Gln Thr Val  Glu Ala Gln Leu Lys  Gln Trp Leu 
    2720                 2725                 2730             


Val Glu  Lys Glu Leu Met Val  Ser Val Leu Gly Pro  Leu Ser Ile 
    2735                 2740                 2745             


Asp Pro  Asn Met Leu Asn Thr  Gln Arg Gln Gln Val  Gln Ile Leu 
    2750                 2755                 2760             


Leu Gln  Glu Phe Ala Thr Arg  Lys Pro Gln Tyr Glu  Gln Leu Thr 
    2765                 2770                 2775             


Ala Ala  Gly Gln Gly Ile Leu  Ser Arg Pro Gly Glu  Asp Pro Ser 
    2780                 2785                 2790             


Leu Arg  Gly Ile Val Lys Glu  Gln Leu Ala Ala Val  Thr Gln Lys 
    2795                 2800                 2805             


Trp Asp  Ser Leu Thr Gly Gln  Leu Ser Asp Arg Cys  Asp Trp Ile 
    2810                 2815                 2820             


Asp Gln  Ala Ile Val Lys Ser  Thr Gln Tyr Gln Ser  Leu Leu Arg 
    2825                 2830                 2835             


Ser Leu  Ser Asp Lys Leu Ser  Asp Leu Asp Asn Lys  Leu Ser Ser 
    2840                 2845                 2850             


Ser Leu  Ala Val Ser Thr His  Pro Asp Ala Met Asn  Gln Gln Leu 
    2855                 2860                 2865             


Glu Thr  Ala Gln Lys Met Lys  Gln Glu Ile Gln Gln  Glu Lys Lys 
    2870                 2875                 2880             


Gln Ile  Lys Val Ala Gln Ala  Leu Cys Glu Asp Leu  Ser Ala Leu 
    2885                 2890                 2895             


Val Lys  Glu Glu Tyr Leu Lys  Ala Glu Leu Ser Arg  Gln Leu Glu 
    2900                 2905                 2910             


Gly Ile  Leu Lys Ser Phe Lys  Asp Val Glu Gln Lys  Ala Glu Asn 
    2915                 2920                 2925             


His Val  Gln His Leu Gln Ser  Ala Cys Ala Ser Ser  His Gln Phe 
    2930                 2935                 2940             


Gln Gln  Met Ser Arg Asp Phe  Gln Ala Trp Leu Asp  Thr Lys Lys 
    2945                 2950                 2955             


Glu Glu  Gln Asn Lys Ser His  Pro Ile Ser Ala Lys  Leu Asp Val 
    2960                 2965                 2970             


Leu Glu  Ser Leu Ile Lys Asp  His Lys Asp Phe Ser  Lys Thr Leu 
    2975                 2980                 2985             


Thr Ala  Gln Ser His Met Tyr  Glu Lys Thr Ile Ala  Glu Gly Glu 
    2990                 2995                 3000             


Asn Leu  Leu Leu Lys Thr Gln  Gly Ser Glu Lys Ala  Ala Leu Gln 
    3005                 3010                 3015             


Leu Gln  Leu Asn Thr Ile Lys  Thr Asn Trp Asp Thr  Phe Asn Lys 
    3020                 3025                 3030             


Gln Val  Lys Glu Arg Glu Asn  Lys Leu Lys Glu Ser  Leu Glu Lys 
    3035                 3040                 3045             


Ala Leu  Lys Tyr Lys Glu Gln  Val Glu Thr Leu Trp  Pro Trp Ile 
    3050                 3055                 3060             


Asp Lys  Cys Gln Asn Asn Leu  Glu Glu Ile Lys Phe  Cys Leu Asp 
    3065                 3070                 3075             


Pro Ala  Glu Gly Glu Asn Ser  Ile Ala Lys Leu Lys  Ser Leu Gln 
    3080                 3085                 3090             


Lys Glu  Met Asp Gln His Phe  Gly Met Val Glu Leu  Leu Asn Asn 
    3095                 3100                 3105             


Thr Ala  Asn Ser Leu Leu Ser  Val Cys Glu Ile Asp  Lys Glu Val 
    3110                 3115                 3120             


Val Thr  Asp Glu Asn Lys Ser  Leu Ile Gln Lys Val  Asp Met Val 
    3125                 3130                 3135             


Thr Glu  Gln Leu His Ser Lys  Lys Phe Cys Leu Glu  Asn Met Thr 
    3140                 3145                 3150             


Gln Lys  Phe Lys Glu Phe Gln  Glu Val Ser Lys Glu  Ser Lys Arg 
    3155                 3160                 3165             


Gln Leu  Gln Cys Ala Lys Glu  Gln Leu Asp Ile His  Asp Ser Leu 
    3170                 3175                 3180             


Gly Ser  Gln Ala Tyr Ser Asn  Lys Tyr Leu Thr Met  Leu Gln Thr 
    3185                 3190                 3195             


Gln Gln  Lys Ser Leu Gln Ala  Leu Lys His Gln Val  Asp Leu Ala 
    3200                 3205                 3210             


Lys Arg  Leu Ala Gln Asp Leu  Val Val Glu Ala Ser  Asp Ser Lys 
    3215                 3220                 3225             


Gly Thr  Ser Asp Val Leu Leu  Gln Val Glu Thr Ile  Ala Gln Glu 
    3230                 3235                 3240             


His Ser  Thr Leu Ser Gln Gln  Val Asp Glu Lys Cys  Ser Phe Leu 
    3245                 3250                 3255             


Glu Thr  Lys Leu Gln Gly Ile  Gly His Phe Gln Asn  Thr Ile Arg 
    3260                 3265                 3270             


Glu Met  Phe Ser Gln Phe Ala  Glu Phe Asp Asp Glu  Leu Asp Ser 
    3275                 3280                 3285             


Met Ala  Pro Val Gly Arg Asp  Ala Glu Thr Leu Gln  Lys Gln Lys 
    3290                 3295                 3300             


Glu Thr  Ile Lys Ala Phe Leu  Lys Lys Leu Glu Ala  Leu Met Ala 
    3305                 3310                 3315             


Ser Asn  Asp Asn Ala Asn Lys  Thr Cys Lys Met Met  Leu Ala Thr 
    3320                 3325                 3330             


Glu Glu  Thr Ser Pro Asp Leu  Val Gly Ile Lys Arg  Asp Leu Glu 
    3335                 3340                 3345             


Ala Leu  Ser Lys Gln Cys Asn  Lys Leu Leu Asp Arg  Ala Gln Ala 
    3350                 3355                 3360             


Arg Glu  Glu Gln Val Glu Gly  Thr Ile Lys Arg Leu  Glu Glu Phe 
    3365                 3370                 3375             


Tyr Ser  Lys Leu Lys Glu Phe  Ser Ile Leu Leu Gln  Lys Ala Glu 
    3380                 3385                 3390             


Glu His  Glu Glu Ser Gln Gly  Pro Val Gly Met Glu  Thr Glu Thr 
    3395                 3400                 3405             


Ile Asn  Gln Gln Leu Asn Met  Phe Lys Val Phe Gln  Lys Glu Glu 
    3410                 3415                 3420             


Ile Glu  Pro Leu Gln Gly Lys  Gln Gln Asp Val Asn  Trp Leu Gly 
    3425                 3430                 3435             


Gln Gly  Leu Ile Gln Ser Ala  Ala Lys Ser Thr Ser  Thr Gln Gly 
    3440                 3445                 3450             


Leu Glu  His Asp Leu Asp Asp  Val Asn Ala Arg Trp  Lys Thr Leu 
    3455                 3460                 3465             


Asn Lys  Lys Val Ala Gln Arg  Ala Ala Gln Leu Gln  Glu Ala Leu 
    3470                 3475                 3480             


Leu His  Cys Gly Arg Phe Gln  Asp Ala Leu Glu Ser  Leu Leu Ser 
    3485                 3490                 3495             


Trp Met  Val Asp Thr Glu Glu  Leu Val Ala Asn Gln  Lys Pro Pro 
    3500                 3505                 3510             


Ser Ala  Glu Phe Lys Val Val  Lys Ala Gln Ile Gln  Glu Gln Lys 
    3515                 3520                 3525             


Leu Leu  Gln Arg Leu Leu Asp  Asp Arg Lys Ser Thr  Val Glu Val 
    3530                 3535                 3540             


Ile Lys  Arg Glu Gly Glu Lys  Ile Ala Thr Thr Ala  Glu Pro Ala 
    3545                 3550                 3555             


Asp Lys  Val Lys Ile Leu Lys  Gln Leu Ser Leu Leu  Asp Ser Arg 
    3560                 3565                 3570             


Trp Glu  Ala Leu Leu Asn Lys  Ala Glu Thr Arg Asn  Arg Gln Leu 
    3575                 3580                 3585             


Glu Gly  Ile Ser Val Val Ala  Gln Gln Phe His Glu  Thr Leu Glu 
    3590                 3595                 3600             


Pro Leu  Asn Glu Trp Leu Thr  Thr Ile Glu Lys Arg  Leu Val Asn 
    3605                 3610                 3615             


Cys Glu  Pro Ile Gly Thr Gln  Ala Ser Lys Leu Glu  Glu Gln Ile 
    3620                 3625                 3630             


Ala Gln  His Lys Ala Leu Glu  Asp Asp Ile Ile Asn  His Asn Lys 
    3635                 3640                 3645             


His Leu  His Gln Ala Val Ser  Ile Gly Gln Ser Leu  Lys Val Leu 
    3650                 3655                 3660             


Ser Ser  Arg Glu Asp Lys Asp  Met Val Gln Ser Lys  Leu Asp Phe 
    3665                 3670                 3675             


Ser Gln  Val Trp Tyr Ile Glu  Ile Gln Glu Lys Ser  His Ser Arg 
    3680                 3685                 3690             


Ser Glu  Leu Leu Gln Gln Ala  Leu Cys Asn Ala Lys  Ile Phe Gly 
    3695                 3700                 3705             


Glu Asp  Glu Val Glu Leu Met  Asn Trp Leu Asn Glu  Val His Asp 
    3710                 3715                 3720             


Lys Leu  Ser Lys Leu Ser Val  Gln Asp Tyr Ser Thr  Glu Gly Leu 
    3725                 3730                 3735             


Trp Lys  Gln Gln Ser Glu Leu  Arg Val Leu Gln Glu  Asp Ile Leu 
    3740                 3745                 3750             


Leu Arg  Lys Gln Asn Val Asp  Gln Ala Leu Leu Asn  Gly Leu Glu 
    3755                 3760                 3765             


Leu Leu  Lys Gln Thr Thr Gly  Asp Glu Val Leu Ile  Ile Gln Asp 
    3770                 3775                 3780             


Lys Leu  Glu Ala Ile Lys Ala  Arg Tyr Lys Asp Ile  Thr Lys Leu 
    3785                 3790                 3795             


Ser Thr  Asp Val Ala Lys Thr  Leu Glu Gln Ala Leu  Gln Leu Ala 
    3800                 3805                 3810             


Arg Arg  Leu His Ser Thr His  Glu Glu Leu Cys Thr  Trp Leu Asp 
    3815                 3820                 3825             


Lys Val  Glu Val Glu Leu Leu  Ser Tyr Glu Thr Gln  Val Leu Lys 
    3830                 3835                 3840             


Gly Glu  Glu Ala Ser Gln Ala  Gln Met Arg Pro Lys  Glu Leu Lys 
    3845                 3850                 3855             


Lys Glu  Ala Lys Asn Asn Lys  Ala Leu Leu Asp Ser  Leu Asn Glu 
    3860                 3865                 3870             


Val Ser  Ser Ala Leu Leu Glu  Leu Val Pro Trp Arg  Ala Arg Glu 
    3875                 3880                 3885             


Gly Leu  Glu Lys Met Val Ala  Glu Asp Asn Glu Arg  Tyr Arg Leu 
    3890                 3895                 3900             


Val Ser  Asp Thr Ile Thr Gln  Lys Val Glu Glu Ile  Asp Ala Ala 
    3905                 3910                 3915             


Ile Leu  Arg Ser Gln Gln Phe  Asp Gln Ala Ala Asp  Ala Glu Leu 
    3920                 3925                 3930             


Ser Trp  Ile Thr Glu Thr Glu  Lys Lys Leu Met Ser  Leu Gly Asp 
    3935                 3940                 3945             


Ile Arg  Leu Glu Gln Asp Gln  Thr Ser Ala Gln Leu  Gln Val Gln 
    3950                 3955                 3960             


Lys Thr  Phe Thr Met Glu Ile  Leu Arg His Lys Asp  Ile Ile Asp 
    3965                 3970                 3975             


Asp Leu  Val Lys Ser Gly His  Lys Ile Met Thr Ala  Cys Ser Glu 
    3980                 3985                 3990             


Glu Glu  Lys Gln Ser Met Lys  Lys Lys Leu Asp Lys  Val Leu Lys 
    3995                 4000                 4005             


Asn Tyr  Asp Thr Ile Cys Gln  Ile Asn Ser Glu Arg  Tyr Leu Gln 
    4010                 4015                 4020             


Leu Glu  Arg Ala Gln Ser Leu  Val Asn Gln Phe Trp  Glu Thr Tyr 
    4025                 4030                 4035             


Glu Glu  Leu Trp Pro Trp Leu  Thr Glu Thr Gln Ser  Ile Ile Ser 
    4040                 4045                 4050             


Gln Leu  Pro Ala Pro Ala Leu  Glu Tyr Glu Thr Leu  Arg Gln Gln 
    4055                 4060                 4065             


Gln Glu  Glu His Arg Gln Leu  Arg Glu Leu Ile Ala  Glu His Lys 
    4070                 4075                 4080             


Pro His  Ile Asp Lys Met Asn  Lys Thr Gly Pro Gln  Leu Leu Glu 
    4085                 4090                 4095             


Leu Ser  Pro Gly Glu Gly Phe  Ser Ile Gln Glu Lys  Tyr Val Ala 
    4100                 4105                 4110             


Ala Asp  Thr Leu Tyr Ser Gln  Ile Lys Glu Asp Val  Lys Lys Arg 
    4115                 4120                 4125             


Ala Val  Ala Leu Asp Glu Ala  Ile Ser Gln Ser Thr  Gln Phe His 
    4130                 4135                 4140             


Asp Lys  Ile Asp Gln Ile Leu  Glu Ser Leu Glu Arg  Ile Val Glu 
    4145                 4150                 4155             


Arg Leu  Arg Gln Pro Pro Ser  Ile Ser Ala Glu Val  Glu Lys Ile 
    4160                 4165                 4170             


Lys Glu  Gln Ile Ser Glu Asn  Lys Asn Val Ser Val  Asp Met Glu 
    4175                 4180                 4185             


Lys Leu  Gln Pro Leu Tyr Glu  Thr Leu Lys Gln Arg  Gly Glu Glu 
    4190                 4195                 4200             


Met Ile  Ala Arg Ser Gly Gly  Thr Asp Lys Asp Ile  Ser Ala Lys 
    4205                 4210                 4215             


Ala Val  Gln Asp Lys Leu Asp  Gln Met Val Phe Ile  Trp Glu Asn 
    4220                 4225                 4230             


Ile His  Thr Leu Val Glu Glu  Arg Glu Ala Lys Leu  Leu Asp Val 
    4235                 4240                 4245             


Met Glu  Leu Ala Glu Lys Phe  Trp Cys Asp His Met  Ser Leu Ile 
    4250                 4255                 4260             


Val Thr  Ile Lys Asp Thr Gln  Asp Phe Ile Arg Asp  Leu Glu Asp 
    4265                 4270                 4275             


Pro Gly  Ile Asp Pro Ser Val  Val Lys Gln Gln Gln  Glu Ala Ala 
    4280                 4285                 4290             


Glu Thr  Ile Arg Glu Glu Ile  Asp Gly Leu Gln Glu  Glu Leu Asp 
    4295                 4300                 4305             


Ile Val  Ile Asn Leu Gly Ser  Glu Leu Ile Ala Ala  Cys Gly Glu 
    4310                 4315                 4320             


Pro Asp  Lys Pro Ile Val Lys  Lys Ser Ile Asp Glu  Leu Asn Ser 
    4325                 4330                 4335             


Ala Trp  Asp Ser Leu Asn Lys  Ala Trp Lys Asp Arg  Ile Asp Lys 
    4340                 4345                 4350             


Leu Glu  Glu Ala Met Gln Ala  Ala Val Gln Tyr Gln  Asp Gly Leu 
    4355                 4360                 4365             


Gln Ala  Val Phe Asp Trp Val  Asp Ile Ala Gly Gly  Lys Leu Ala 
    4370                 4375                 4380             


Ser Met  Ser Pro Ile Gly Thr  Asp Leu Glu Thr Val  Lys Gln Gln 
    4385                 4390                 4395             


Ile Glu  Glu Leu Lys Gln Phe  Lys Ser Glu Ala Tyr  Gln Gln Gln 
    4400                 4405                 4410             


Ile Glu  Met Glu Arg Leu Asn  His Gln Ala Glu Leu  Leu Leu Lys 
    4415                 4420                 4425             


Lys Val  Thr Glu Glu Ser Asp  Lys His Thr Val Gln  Asp Pro Leu 
    4430                 4435                 4440             


Met Glu  Leu Lys Leu Ile Trp  Asp Ser Leu Glu Glu  Arg Ile Ile 
    4445                 4450                 4455             


Asn Arg  Gln His Lys Leu Glu  Gly Ala Leu Leu Ala  Leu Gly Gln 
    4460                 4465                 4470             


Phe Gln  His Ala Leu Asp Glu  Leu Leu Ala Trp Leu  Thr His Thr 
    4475                 4480                 4485             


Glu Gly  Leu Leu Ser Glu Gln  Lys Pro Val Gly Gly  Asp Pro Lys 
    4490                 4495                 4500             


Ala Ile  Glu Ile Glu Leu Ala  Lys His His Val Leu  Gln Asn Asp 
    4505                 4510                 4515             


Val Leu  Ala His Gln Ser Thr  Val Glu Ala Val Asn  Lys Ala Gly 
    4520                 4525                 4530             


Asn Asp  Leu Ile Glu Ser Ser  Ala Gly Glu Glu Ala  Ser Asn Leu 
    4535                 4540                 4545             


Gln Asn  Lys Leu Glu Val Leu  Asn Gln Arg Trp Gln  Asn Val Leu 
    4550                 4555                 4560             


Glu Lys  Thr Glu Gln Arg Lys  Gln Gln Leu Asp Gly  Ala Leu Arg 
    4565                 4570                 4575             


Gln Ala  Lys Gly Phe His Gly  Glu Ile Glu Asp Leu  Gln Gln Trp 
    4580                 4585                 4590             


Leu Thr  Asp Thr Glu Arg His  Leu Leu Ala Ser Lys  Pro Leu Gly 
    4595                 4600                 4605             


Gly Leu  Pro Glu Thr Ala Lys  Glu Gln Leu Asn Val  His Met Glu 
    4610                 4615                 4620             


Val Cys  Ala Ala Phe Glu Ala  Lys Glu Glu Thr Tyr  Lys Ser Leu 
    4625                 4630                 4635             


Met Gln  Lys Gly Gln Gln Met  Leu Ala Arg Cys Pro  Lys Ser Ala 
    4640                 4645                 4650             


Glu Thr  Asn Ile Asp Gln Asp  Ile Asn Asn Leu Lys  Glu Lys Trp 
    4655                 4660                 4665             


Glu Ser  Val Glu Thr Lys Leu  Asn Glu Arg Lys Thr  Lys Leu Glu 
    4670                 4675                 4680             


Glu Ala  Leu Asn Leu Ala Met  Glu Phe His Asn Ser  Leu Gln Asp 
    4685                 4690                 4695             


Phe Ile  Asn Trp Leu Thr Gln  Ala Glu Gln Thr Leu  Asn Val Ala 
    4700                 4705                 4710             


Ser Arg  Pro Ser Leu Ile Leu  Asp Thr Val Leu Phe  Gln Ile Asp 
    4715                 4720                 4725             


Glu His  Lys Val Phe Ala Asn  Glu Val Asn Ser His  Arg Glu Gln 
    4730                 4735                 4740             


Ile Ile  Glu Leu Asp Lys Thr  Gly Thr His Leu Lys  Tyr Phe Ser 
    4745                 4750                 4755             


Gln Lys  Gln Asp Val Val Leu  Ile Lys Asn Leu Leu  Ile Ser Val 
    4760                 4765                 4770             


Gln Ser  Arg Trp Glu Lys Val  Val Gln Arg Leu Val  Glu Arg Gly 
    4775                 4780                 4785             


Arg Ser  Leu Asp Asp Ala Arg  Lys Arg Ala Lys Gln  Phe His Glu 
    4790                 4795                 4800             


Ala Trp  Ser Lys Leu Met Glu  Trp Leu Glu Glu Ser  Glu Lys Ser 
    4805                 4810                 4815             


Leu Asp  Ser Glu Leu Glu Ile  Ala Asn Asp Pro Asp  Lys Ile Lys 
    4820                 4825                 4830             


Thr Gln  Leu Ala Gln His Lys  Glu Phe Gln Lys Ser  Leu Gly Ala 
    4835                 4840                 4845             


Lys His  Ser Val Tyr Asp Thr  Thr Asn Arg Thr Gly  Arg Ser Leu 
    4850                 4855                 4860             


Lys Glu  Lys Thr Ser Leu Ala  Asp Asp Asn Leu Lys  Leu Asp Asp 
    4865                 4870                 4875             


Met Leu  Ser Glu Leu Arg Asp  Lys Trp Asp Thr Ile  Cys Gly Lys 
    4880                 4885                 4890             


Ser Val  Glu Arg Gln Asn Lys  Leu Glu Glu Ala Leu  Leu Phe Ser 
    4895                 4900                 4905             


Gly Gln  Phe Thr Asp Ala Leu  Gln Ala Leu Ile Asp  Trp Leu Tyr 
    4910                 4915                 4920             


Arg Val  Glu Pro Gln Leu Ala  Glu Asp Gln Pro Val  His Gly Asp 
    4925                 4930                 4935             


Ile Asp  Leu Val Met Asn Leu  Ile Asp Asn His Lys  Ala Phe Gln 
    4940                 4945                 4950             


Lys Glu  Leu Gly Lys Arg Thr  Ser Ser Val Gln Ala  Leu Lys Arg 
    4955                 4960                 4965             


Ser Ala  Arg Glu Leu Ile Glu  Gly Ser Arg Asp Asp  Ser Ser Trp 
    4970                 4975                 4980             


Val Lys  Val Gln Met Gln Glu  Leu Ser Thr Arg Trp  Glu Thr Val 
    4985                 4990                 4995             


Cys Ala  Leu Ser Ile Ser Lys  Gln Thr Arg Leu Glu  Ala Ala Leu 
    5000                 5005                 5010             


Arg Gln  Ala Glu Glu Phe His  Ser Val Val His Ala  Leu Leu Glu 
    5015                 5020                 5025             


Trp Leu  Ala Glu Ala Glu Gln  Thr Leu Arg Phe His  Gly Val Leu 
    5030                 5035                 5040             


Pro Asp  Asp Glu Asp Ala Leu  Arg Thr Leu Ile Asp  Gln His Lys 
    5045                 5050                 5055             


Glu Phe  Met Lys Lys Leu Glu  Glu Lys Arg Ala Glu  Leu Asn Lys 
    5060                 5065                 5070             


Ala Thr  Thr Met Gly Asp Thr  Val Leu Ala Ile Cys  His Pro Asp 
    5075                 5080                 5085             


Ser Ile  Thr Thr Ile Lys His  Trp Ile Thr Ile Ile  Arg Ala Arg 
    5090                 5095                 5100             


Phe Glu  Glu Val Leu Ala Trp  Ala Lys Gln His Gln  Gln Arg Leu 
    5105                 5110                 5115             


Ala Ser  Ala Leu Ala Gly Leu  Ile Ala Lys Gln Glu  Leu Leu Glu 
    5120                 5125                 5130             


Ala Leu  Leu Ala Trp Leu Gln  Trp Ala Glu Thr Thr  Leu Thr Asp 
    5135                 5140                 5145             


Lys Asp  Lys Glu Val Ile Pro  Gln Glu Ile Glu Glu  Val Lys Ala 
    5150                 5155                 5160             


Leu Ile  Ala Glu His Gln Thr  Phe Met Glu Glu Met  Thr Arg Lys 
    5165                 5170                 5175             


Gln Pro  Asp Val Asp Lys Val  Thr Lys Thr Tyr Lys  Arg Arg Ala 
    5180                 5185                 5190             


Ala Asp  Pro Ser Ser Leu Gln  Ser His Ile Pro Val  Leu Asp Lys 
    5195                 5200                 5205             


Gly Arg  Ala Gly Arg Lys Arg  Phe Pro Ala Ser Ser  Leu Tyr Pro 
    5210                 5215                 5220             


Ser Gly  Ser Gln Thr Gln Ile  Glu Thr Lys Asn Pro  Arg Val Asn 
    5225                 5230                 5235             


Leu Leu  Val Ser Lys Trp Gln  Gln Val Trp Leu Leu  Ala Leu Glu 
    5240                 5245                 5250             


Arg Arg  Arg Lys Leu Asn Asp  Ala Leu Asp Arg Leu  Glu Glu Leu 
    5255                 5260                 5265             


Arg Glu  Phe Ala Asn Phe Asp  Phe Asp Ile Trp Arg  Lys Lys Tyr 
    5270                 5275                 5280             


Met Arg  Trp Met Asn His Lys  Lys Ser Arg Val Met  Asp Phe Phe 
    5285                 5290                 5295             


Arg Arg  Ile Asp Lys Asp Gln  Asp Gly Lys Ile Thr  Arg Gln Glu 
    5300                 5305                 5310             


Phe Ile  Asp Gly Ile Leu Ser  Ser Lys Phe Pro Thr  Ser Arg Leu 
    5315                 5320                 5325             


Glu Met  Ser Ala Val Ala Asp  Ile Phe Asp Arg Asp  Gly Asp Gly 
    5330                 5335                 5340             


Tyr Ile  Asp Tyr Tyr Glu Phe  Val Ala Ala Leu His  Pro Asn Lys 
    5345                 5350                 5355             


Asp Ala  Tyr Lys Pro Ile Thr  Asp Ala Asp Lys Ile  Glu Asp Glu 
    5360                 5365                 5370             


Val Thr  Arg Gln Val Ala Lys  Cys Lys Cys Ala Lys  Arg Phe Gln 
    5375                 5380                 5385             


Val Glu  Gln Ile Gly Asp Asn  Lys Tyr Arg Phe Phe  Leu Gly Asn 
    5390                 5395                 5400             


Gln Phe  Gly Asp Ser Gln Gln  Leu Arg Leu Val Arg  Ile Leu Arg 
    5405                 5410                 5415             


Ser Thr  Val Met Val Arg Val  Gly Gly Gly Trp Met  Ala Leu Asp 
    5420                 5425                 5430             


Glu Phe  Leu Val Lys Asn Asp  Pro Cys Arg Ala Lys  Gly Arg Thr 
    5435                 5440                 5445             


Asn Met  Glu Leu Arg Glu Lys  Phe Ile Leu Ala Asp  Gly Ala Ser 
    5450                 5455                 5460             


Gln Gly  Met Ala Ala Phe Arg  Pro Arg Gly Arg Arg  Ser Arg Pro 
    5465                 5470                 5475             


Ser Ser  Arg Gly Ala Ser Pro  Asn Arg Ser Thr Ser  Val Ser Ser 
    5480                 5485                 5490             


Gln Ala  Ala Gln Ala Ala Ser  Pro Gln Val Pro Ala  Thr Thr Thr 
    5495                 5500                 5505             


Pro Lys  Ile Leu His Pro Leu  Thr Arg Asn Tyr Gly  Lys Pro Trp 
    5510                 5515                 5520             


Leu Thr  Asn Ser Lys Met Ser  Thr Pro Cys Lys Ala  Ala Glu Cys 
    5525                 5530                 5535             


Ser Asp  Phe Pro Val Pro Ser  Ala Glu Gly Thr Pro  Ile Gln Gly 
    5540                 5545                 5550             


Ser Lys  Leu Arg Leu Pro Gly  Tyr Leu Ser Gly Lys  Gly Phe His 
    5555                 5560                 5565             


Ser Gly  Glu Asp Ser Gly Leu  Ile Thr Thr Ala Ala  Ala Arg Val 
    5570                 5575                 5580             


Arg Thr  Gln Phe Ala Asp Ser  Lys Lys Thr Pro Ser  Arg Pro Gly 
    5585                 5590                 5595             


Ser Arg  Ala Gly Ser Lys Ala  Gly Ser Arg Ala Ser  Ser Arg Arg 
    5600                 5605                 5610             


Gly Ser  Asp Ala Ser Asp Phe  Asp Ile Ser Glu Ile  Gln Ser Val 
    5615                 5620                 5625             


Cys Ser  Asp Val Glu Thr Val  Pro Gln Thr His Arg  Pro Thr Pro 
    5630                 5635                 5640             


Arg Ala  Gly Ser Arg Pro Ser  Thr Ala Lys Pro Ser  Lys Ile Pro 
    5645                 5650                 5655             


Thr Pro  Gln Arg Lys Ser Pro  Ala Ser Lys Leu Asp  Lys Ser Ser 
    5660                 5665                 5670             


Lys Arg  
    5675 


<210>  1773
<211>  5537
<212>  PRT
<213>  Homo sapiens

<400>  1773

Met Ser Ser Gly Asn Ala Ser Tyr Arg Cys Ser Met Ser Ser Ser Ala 
1               5                   10                  15      


Asp Phe Ser Asp Glu Asp Asp Phe Ser Gln Lys Ser Gly Ser Ala Ser 
            20                  25                  30          


Pro Ala Pro Gly Asp Thr Leu Pro Trp Asn Leu Pro Lys His Glu Arg 
        35                  40                  45              


Ser Lys Arg Lys Ile Gln Gly Gly Ser Val Leu Asp Pro Ala Glu Arg 
    50                  55                  60                  


Ala Val Leu Arg Ile Ala Asp Glu Arg Asp Lys Val Gln Lys Lys Thr 
65                  70                  75                  80  


Phe Thr Lys Trp Ile Asn Gln His Leu Met Lys Val Arg Lys His Val 
                85                  90                  95      


Asn Asp Leu Tyr Glu Asp Leu Arg Asp Gly His Asn Leu Ile Ser Leu 
            100                 105                 110         


Leu Glu Val Leu Ser Gly Asp Thr Leu Pro Arg Glu Lys Gly Arg Met 
        115                 120                 125             


Arg Phe His Arg Leu Gln Asn Val Gln Ile Ala Leu Asp Tyr Leu Lys 
    130                 135                 140                 


Arg Arg Gln Val Lys Leu Val Asn Ile Arg Asn Asp Asp Ile Thr Asp 
145                 150                 155                 160 


Gly Asn Pro Lys Leu Thr Leu Gly Leu Ile Trp Thr Ile Ile Leu His 
                165                 170                 175     


Phe Gln Ile Ser Asp Ile His Val Thr Gly Glu Ser Glu Asp Met Ser 
            180                 185                 190         


Ala Lys Glu Arg Leu Leu Leu Trp Thr Gln Gln Ala Thr Glu Gly Tyr 
        195                 200                 205             


Ala Gly Ile Arg Cys Glu Asn Phe Thr Thr Cys Trp Arg Asp Gly Lys 
    210                 215                 220                 


Leu Phe Asn Ala Ile Ile His Lys Tyr Arg Pro Asp Leu Ile Asp Met 
225                 230                 235                 240 


Asn Thr Val Ala Val Gln Ser Asn Leu Ala Asn Leu Glu His Ala Phe 
                245                 250                 255     


Tyr Val Ala Glu Lys Ile Gly Val Ile Arg Leu Leu Asp Pro Glu Asp 
            260                 265                 270         


Val Asp Val Ser Ser Pro Asp Glu Lys Ser Val Ile Thr Tyr Val Ser 
        275                 280                 285             


Ser Leu Tyr Asp Ala Phe Pro Lys Val Pro Glu Gly Gly Glu Gly Ile 
    290                 295                 300                 


Gly Ala Asn Asp Val Glu Val Lys Trp Ile Glu Tyr Gln Asn Met Val 
305                 310                 315                 320 


Asn Tyr Leu Ile Gln Trp Ile Arg His His Val Thr Thr Met Ser Glu 
                325                 330                 335     


Arg Thr Phe Pro Asn Asn Pro Val Glu Leu Lys Ala Leu Tyr Asn Gln 
            340                 345                 350         


Tyr Leu Gln Phe Lys Glu Thr Glu Ile Pro Pro Lys Glu Thr Glu Lys 
        355                 360                 365             


Ser Lys Ile Lys Arg Leu Tyr Lys Leu Leu Glu Ile Trp Ile Glu Phe 
    370                 375                 380                 


Gly Arg Ile Lys Leu Leu Gln Gly Tyr His Pro Asn Asp Ile Glu Lys 
385                 390                 395                 400 


Glu Trp Gly Lys Leu Ile Ile Ala Met Leu Glu Arg Glu Lys Ala Leu 
                405                 410                 415     


Arg Pro Glu Val Glu Arg Leu Glu Met Leu Gln Gln Ile Ala Asn Arg 
            420                 425                 430         


Val Gln Arg Asp Ser Val Ile Cys Glu Asp Lys Leu Ile Leu Ala Gly 
        435                 440                 445             


Asn Ala Leu Gln Ser Asp Ser Lys Arg Leu Glu Ser Gly Val Gln Phe 
    450                 455                 460                 


Gln Asn Glu Ala Glu Ile Ala Gly Tyr Ile Leu Glu Cys Glu Asn Leu 
465                 470                 475                 480 


Leu Arg Gln His Val Ile Asp Val Gln Ile Leu Ile Asp Gly Lys Tyr 
                485                 490                 495     


Tyr Gln Ala Asp Gln Leu Val Gln Arg Val Ala Lys Leu Arg Asp Glu 
            500                 505                 510         


Ile Met Ala Leu Arg Asn Glu Cys Ser Ser Val Tyr Ser Lys Gly Arg 
        515                 520                 525             


Ile Leu Thr Thr Glu Gln Thr Lys Leu Met Ile Ser Gly Ile Thr Gln 
    530                 535                 540                 


Ser Leu Asn Ser Gly Phe Ala Gln Thr Leu His Pro Ser Leu Thr Ser 
545                 550                 555                 560 


Gly Leu Thr Gln Ser Leu Thr Pro Ser Leu Thr Ser Ser Ser Met Thr 
                565                 570                 575     


Ser Gly Leu Ser Ser Gly Met Thr Ser Arg Leu Thr Pro Ser Val Thr 
            580                 585                 590         


Pro Ala Tyr Thr Pro Gly Phe Pro Ser Gly Leu Val Pro Asn Phe Ser 
        595                 600                 605             


Ser Gly Val Glu Pro Asn Ser Leu Gln Thr Leu Lys Leu Met Gln Ile 
    610                 615                 620                 


Arg Lys Pro Leu Leu Lys Ser Ser Leu Leu Asp Gln Asn Leu Thr Glu 
625                 630                 635                 640 


Glu Glu Ile Asn Met Lys Phe Val Gln Asp Leu Leu Asn Trp Val Asp 
                645                 650                 655     


Glu Met Gln Val Gln Leu Asp Arg Thr Glu Trp Gly Ser Asp Leu Pro 
            660                 665                 670         


Ser Val Glu Ser His Leu Glu Asn His Lys Asn Val His Arg Ala Ile 
        675                 680                 685             


Glu Glu Phe Glu Ser Ser Leu Lys Glu Ala Lys Ile Ser Glu Ile Gln 
    690                 695                 700                 


Met Thr Ala Pro Leu Lys Leu Thr Tyr Ala Glu Lys Leu His Arg Leu 
705                 710                 715                 720 


Glu Ser Gln Tyr Ala Lys Leu Leu Asn Thr Ser Arg Asn Gln Glu Arg 
                725                 730                 735     


His Leu Asp Thr Leu His Asn Phe Val Ser Arg Ala Thr Asn Glu Leu 
            740                 745                 750         


Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu Val Ala Tyr Asp Trp Ser 
        755                 760                 765             


Glu Arg Asn Thr Asn Ile Ala Arg Lys Lys Asp Tyr His Ala Glu Leu 
    770                 775                 780                 


Met Arg Glu Leu Asp Gln Lys Glu Glu Asn Ile Lys Ser Val Gln Glu 
785                 790                 795                 800 


Ile Ala Glu Gln Leu Leu Leu Glu Asn His Pro Ala Arg Leu Thr Ile 
                805                 810                 815     


Glu Ala Tyr Arg Ala Ala Met Gln Thr Gln Trp Ser Trp Ile Leu Gln 
            820                 825                 830         


Leu Cys Gln Cys Val Glu Gln His Ile Lys Glu Asn Thr Ala Tyr Phe 
        835                 840                 845             


Glu Phe Phe Asn Asp Ala Lys Glu Ala Thr Asp Tyr Leu Arg Asn Leu 
    850                 855                 860                 


Lys Asp Ala Ile Gln Arg Lys Tyr Ser Cys Asp Arg Ser Ser Ser Ile 
865                 870                 875                 880 


His Lys Leu Glu Asp Leu Val Gln Glu Ser Met Glu Glu Lys Glu Glu 
                885                 890                 895     


Leu Leu Gln Tyr Lys Ser Thr Ile Ala Asn Leu Met Gly Lys Ala Lys 
            900                 905                 910         


Thr Ile Ile Gln Leu Lys Pro Arg Asn Ser Asp Cys Pro Leu Lys Thr 
        915                 920                 925             


Ser Ile Pro Ile Lys Ala Ile Cys Asp Tyr Arg Gln Ile Glu Ile Thr 
    930                 935                 940                 


Ile Tyr Lys Asp Asp Glu Cys Val Leu Ala Asn Asn Ser His Arg Ala 
945                 950                 955                 960 


Lys Trp Lys Val Ile Ser Pro Thr Gly Asn Glu Ala Met Val Pro Ser 
                965                 970                 975     


Val Cys Phe Thr Val Pro Pro Pro Asn Lys Glu Ala Val Asp Leu Ala 
            980                 985                 990         


Asn Arg Ile Glu Gln Gln Tyr Gln  Asn Val Leu Thr Leu  Trp His Glu 
        995                 1000                 1005             


Ser His  Ile Asn Met Lys Ser  Val Val Ser Trp His  Tyr Leu Ile 
    1010                 1015                 1020             


Asn Glu  Ile Asp Arg Ile Arg  Ala Ser Asn Val Ala  Ser Ile Lys 
    1025                 1030                 1035             


Thr Met  Leu Pro Gly Glu His  Gln Gln Val Leu Ser  Asn Leu Gln 
    1040                 1045                 1050             


Ser Arg  Phe Glu Asp Phe Leu  Glu Asp Ser Gln Glu  Ser Gln Val 
    1055                 1060                 1065             


Phe Ser  Gly Ser Asp Ile Thr  Gln Leu Glu Lys Glu  Val Asn Val 
    1070                 1075                 1080             


Cys Lys  Gln Tyr Tyr Gln Glu  Leu Leu Lys Ser Ala  Glu Arg Glu 
    1085                 1090                 1095             


Glu Gln  Glu Glu Ser Val Tyr  Asn Leu Tyr Ile Ser  Glu Val Arg 
    1100                 1105                 1110             


Asn Ile  Arg Leu Arg Leu Glu  Asn Cys Glu Asp Arg  Leu Ile Arg 
    1115                 1120                 1125             


Gln Ile  Arg Thr Pro Leu Glu  Arg Asp Asp Leu His  Glu Ser Val 
    1130                 1135                 1140             


Phe Arg  Ile Thr Glu Gln Glu  Lys Leu Lys Lys Glu  Leu Glu Arg 
    1145                 1150                 1155             


Leu Lys  Asp Asp Leu Gly Thr  Ile Thr Asn Lys Cys  Glu Glu Phe 
    1160                 1165                 1170             


Phe Ser  Gln Ala Ala Ala Ser  Ser Ser Val Pro Thr  Leu Arg Ser 
    1175                 1180                 1185             


Glu Leu  Asn Val Val Leu Gln  Asn Met Asn Gln Val  Tyr Ser Met 
    1190                 1195                 1200             


Ser Ser  Thr Tyr Ile Asp Lys  Leu Lys Thr Val Asn  Leu Val Leu 
    1205                 1210                 1215             


Lys Asn  Thr Gln Ala Ala Glu  Ala Leu Val Lys Leu  Tyr Glu Thr 
    1220                 1225                 1230             


Lys Leu  Cys Glu Glu Glu Ala  Val Ile Ala Asp Lys  Asn Asn Ile 
    1235                 1240                 1245             


Glu Asn  Leu Ile Ser Thr Leu  Lys Gln Trp Arg Ser  Glu Val Asp 
    1250                 1255                 1260             


Glu Lys  Arg Gln Val Phe His  Ala Leu Glu Asp Glu  Leu Gln Lys 
    1265                 1270                 1275             


Ala Lys  Ala Ile Ser Asp Glu  Met Phe Lys Thr Tyr  Lys Glu Arg 
    1280                 1285                 1290             


Asp Leu  Asp Phe Asp Trp His  Lys Glu Lys Ala Asp  Gln Leu Val 
    1295                 1300                 1305             


Glu Arg  Trp Gln Asn Val His  Val Gln Ile Asp Asn  Arg Leu Arg 
    1310                 1315                 1320             


Asp Leu  Glu Gly Ile Gly Lys  Ser Leu Lys Tyr Tyr  Arg Asp Thr 
    1325                 1330                 1335             


Tyr His  Pro Leu Asp Asp Trp  Ile Gln Gln Val Glu  Thr Thr Gln 
    1340                 1345                 1350             


Arg Lys  Ile Gln Glu Asn Gln  Pro Glu Asn Ser Lys  Thr Leu Ala 
    1355                 1360                 1365             


Thr Gln  Leu Asn Gln Gln Lys  Met Leu Val Ser Glu  Ile Glu Met 
    1370                 1375                 1380             


Lys Gln  Ser Lys Met Asp Glu  Cys Gln Lys Tyr Ala  Glu Gln Tyr 
    1385                 1390                 1395             


Ser Ala  Thr Val Lys Asp Tyr  Glu Leu Gln Thr Met  Thr Tyr Arg 
    1400                 1405                 1410             


Ala Met  Val Asp Ser Gln Gln  Lys Ser Pro Val Lys  Arg Arg Arg 
    1415                 1420                 1425             


Met Gln  Ser Ser Ala Asp Leu  Ile Ile Gln Glu Phe  Met Asp Leu 
    1430                 1435                 1440             


Arg Thr  Arg Tyr Thr Ala Leu  Val Thr Leu Met Thr  Gln Tyr Ile 
    1445                 1450                 1455             


Lys Phe  Ala Gly Asp Ser Leu  Lys Arg Leu Glu Glu  Glu Glu Lys 
    1460                 1465                 1470             


Ser Leu  Glu Glu Glu Lys Lys  Glu His Val Glu Lys  Ala Lys Glu 
    1475                 1480                 1485             


Leu Gln  Lys Trp Val Ser Asn  Ile Ser Lys Thr Leu  Lys Asp Ala 
    1490                 1495                 1500             


Glu Lys  Ala Gly Lys Pro Pro  Phe Ser Lys Gln Lys  Ile Ser Ser 
    1505                 1510                 1515             


Glu Glu  Ile Ser Thr Lys Lys  Glu Gln Leu Ser Glu  Ala Leu Gln 
    1520                 1525                 1530             


Thr Ile  Gln Leu Phe Leu Ala  Lys His Gly Asp Lys  Met Thr Asp 
    1535                 1540                 1545             


Glu Glu  Arg Asn Glu Leu Glu  Lys Gln Val Lys Thr  Leu Gln Glu 
    1550                 1555                 1560             


Ser Tyr  Asn Leu Leu Phe Ser  Glu Ser Leu Lys Gln  Leu Gln Glu 
    1565                 1570                 1575             


Ser Gln  Thr Ser Gly Asp Val  Lys Val Glu Glu Lys  Ile Val Ala 
    1580                 1585                 1590             


Glu Arg  Gln Gln Glu Tyr Lys  Glu Lys Leu Gln Gly  Ile Cys Asp 
    1595                 1600                 1605             


Leu Leu  Thr Gln Thr Glu Asn  Arg Leu Ile Gly His  Gln Glu Ala 
    1610                 1615                 1620             


Phe Met  Ile Gly Asp Gly Thr  Val Glu Leu Lys Lys  Tyr Gln Ser 
    1625                 1630                 1635             


Lys Gln  Glu Glu Leu Gln Lys  Asp Met Gln Gly Ser  Ala Gln Ala 
    1640                 1645                 1650             


Leu Ala  Glu Val Val Lys Asn  Thr Glu Asn Phe Leu  Lys Glu Asn 
    1655                 1660                 1665             


Gly Glu  Lys Leu Ser Gln Glu  Asp Lys Ala Leu Ile  Glu Gln Lys 
    1670                 1675                 1680             


Leu Asn  Glu Ala Lys Ile Lys  Cys Glu Gln Leu Asn  Leu Lys Ala 
    1685                 1690                 1695             


Glu Gln  Ser Lys Lys Glu Leu  Asp Lys Val Val Thr  Thr Ala Ile 
    1700                 1705                 1710             


Lys Glu  Glu Thr Glu Lys Val  Ala Ala Val Lys Gln  Leu Glu Glu 
    1715                 1720                 1725             


Ser Lys  Thr Lys Ile Glu Asn  Leu Leu Asp Trp Leu  Ser Asn Val 
    1730                 1735                 1740             


Asp Lys  Asp Ser Glu Arg Ala  Gly Thr Lys His Lys  Gln Val Ile 
    1745                 1750                 1755             


Glu Gln  Asn Gly Thr His Phe  Gln Glu Gly Asp Gly  Lys Ser Ala 
    1760                 1765                 1770             


Ile Gly  Glu Glu Asp Glu Val  Asn Gly Asn Leu Leu  Glu Thr Asp 
    1775                 1780                 1785             


Val Asp  Gly Gln Val Gly Thr  Thr Gln Glu Asn Leu  Asn Gln Gln 
    1790                 1795                 1800             


Tyr Gln  Lys Val Lys Ala Gln  His Glu Lys Ile Ile  Ser Gln His 
    1805                 1810                 1815             


Gln Ala  Val Ile Ile Ala Thr  Gln Ser Ala Gln Val  Leu Leu Glu 
    1820                 1825                 1830             


Lys Gln  Gly Gln Tyr Leu Ser  Pro Glu Glu Lys Glu  Lys Leu Gln 
    1835                 1840                 1845             


Lys Asn  Met Lys Glu Leu Lys  Val His Tyr Glu Thr  Ala Leu Ala 
    1850                 1855                 1860             


Glu Ser  Glu Lys Lys Met Lys  Leu Thr His Ser Leu  Gln Glu Glu 
    1865                 1870                 1875             


Leu Glu  Lys Phe Asp Ala Asp  Tyr Thr Glu Phe Glu  His Trp Leu 
    1880                 1885                 1890             


Gln Gln  Ser Glu Gln Glu Leu  Glu Asn Leu Glu Ala  Gly Ala Asp 
    1895                 1900                 1905             


Asp Ile  Asn Gly Leu Met Thr  Lys Leu Lys Arg Gln  Lys Ser Phe 
    1910                 1915                 1920             


Ser Glu  Asp Val Ile Ser His  Lys Gly Asp Leu Arg  Tyr Ile Thr 
    1925                 1930                 1935             


Ile Ser  Gly Asn Arg Val Leu  Glu Ala Ala Lys Ser  Cys Ser Lys 
    1940                 1945                 1950             


Arg Asp  Gly Gly Lys Val Asp  Thr Ser Ala Thr His  Arg Glu Val 
    1955                 1960                 1965             


Gln Arg  Lys Leu Asp His Ala  Thr Asp Arg Phe Arg  Ser Leu Tyr 
    1970                 1975                 1980             


Ser Lys  Cys Asn Val Leu Gly  Asn Asn Leu Lys Asp  Leu Val Asp 
    1985                 1990                 1995             


Lys Tyr  Gln His Tyr Glu Asp  Ala Ser Cys Gly Leu  Leu Ala Gly 
    2000                 2005                 2010             


Leu Gln  Ala Cys Glu Ala Thr  Ala Ser Lys His Leu  Ser Glu Pro 
    2015                 2020                 2025             


Ile Ala  Val Asp Pro Lys Asn  Leu Gln Arg Gln Leu  Glu Glu Thr 
    2030                 2035                 2040             


Lys Ala  Leu Gln Gly Gln Ile  Ser Ser Gln Gln Val  Ala Val Glu 
    2045                 2050                 2055             


Lys Leu  Lys Lys Thr Ala Glu  Val Leu Leu Asp Ala  Arg Gly Ser 
    2060                 2065                 2070             


Leu Leu  Pro Ala Lys Asn Asp  Ile Gln Lys Thr Leu  Asp Asp Ile 
    2075                 2080                 2085             


Val Gly  Arg Tyr Glu Asp Leu  Ser Lys Ser Val Asn  Glu Arg Asn 
    2090                 2095                 2100             


Glu Lys  Leu Gln Ile Thr Leu  Thr Arg Ser Leu Ser  Val Gln Asp 
    2105                 2110                 2115             


Gly Leu  Asp Glu Met Leu Asp  Trp Met Gly Asn Val  Glu Ser Ser 
    2120                 2125                 2130             


Leu Lys  Glu Gln Gly Gln Val  Pro Leu Asn Ser Thr  Ala Leu Gln 
    2135                 2140                 2145             


Asp Ile  Ile Ser Lys Asn Ile  Met Leu Glu Gln Asp  Ile Ala Gly 
    2150                 2155                 2160             


Arg Gln  Ser Ser Ile Asn Ala  Met Asn Glu Lys Val  Lys Lys Phe 
    2165                 2170                 2175             


Met Glu  Thr Thr Asp Pro Ser  Thr Ala Ser Ser Leu  Gln Ala Lys 
    2180                 2185                 2190             


Met Lys  Asp Leu Ser Ala Arg  Phe Ser Glu Ala Ser  His Lys His 
    2195                 2200                 2205             


Lys Glu  Thr Leu Ala Lys Met  Glu Glu Leu Lys Thr  Lys Val Glu 
    2210                 2215                 2220             


Leu Phe  Glu Asn Leu Ser Glu  Lys Leu Gln Thr Phe  Leu Glu Thr 
    2225                 2230                 2235             


Lys Thr  Gln Ala Leu Thr Glu  Val Asp Val Pro Gly  Lys Asp Val 
    2240                 2245                 2250             


Thr Glu  Leu Ser Gln Tyr Met  Gln Glu Ser Thr Ser  Glu Phe Leu 
    2255                 2260                 2265             


Glu His  Lys Lys His Leu Glu  Val Leu His Ser Leu  Leu Lys Glu 
    2270                 2275                 2280             


Ile Ser  Ser His Gly Leu Pro  Ser Asp Lys Ala Leu  Val Leu Glu 
    2285                 2290                 2295             


Lys Thr  Asn Asn Leu Ser Lys  Lys Phe Lys Glu Met  Glu Asp Thr 
    2300                 2305                 2310             


Ile Lys  Glu Lys Lys Glu Ala  Val Thr Ser Cys Gln  Glu Gln Leu 
    2315                 2320                 2325             


Asp Ala  Phe Gln Val Leu Val  Lys Ser Leu Lys Ser  Trp Ile Lys 
    2330                 2335                 2340             


Glu Thr  Thr Lys Lys Val Pro  Ile Val Gln Pro Ser  Phe Gly Ala 
    2345                 2350                 2355             


Glu Asp  Leu Gly Lys Ser Leu  Glu Asp Thr Lys Lys  Leu Gln Glu 
    2360                 2365                 2370             


Lys Trp  Ser Leu Lys Thr Pro  Glu Ile Gln Lys Val  Asn Asn Ser 
    2375                 2380                 2385             


Gly Ile  Ser Leu Cys Asn Leu  Ile Ser Ala Val Thr  Thr Pro Ala 
    2390                 2395                 2400             


Lys Ala  Ile Ala Ala Val Lys  Ser Gly Gly Ala Val  Leu Asn Gly 
    2405                 2410                 2415             


Glu Gly  Thr Ala Thr Asn Thr  Glu Glu Phe Trp Ala  Asn Lys Gly 
    2420                 2425                 2430             


Leu Thr  Ser Ile Lys Lys Asp  Met Thr Asp Ile Ser  His Gly Tyr 
    2435                 2440                 2445             


Glu Asp  Leu Gly Leu Leu Leu  Lys Asp Lys Ile Ala  Glu Leu Asn 
    2450                 2455                 2460             


Thr Lys  Leu Ser Lys Leu Gln  Lys Ala Gln Glu Glu  Ser Ser Ala 
    2465                 2470                 2475             


Met Met  Gln Trp Leu Gln Lys  Met Asn Lys Thr Ala  Thr Lys Trp 
    2480                 2485                 2490             


Gln Gln  Thr Pro Ala Pro Thr  Asp Thr Glu Ala Val  Lys Thr Gln 
    2495                 2500                 2505             


Val Glu  Gln Asn Lys Ser Phe  Glu Ala Glu Leu Lys  Gln Asn Val 
    2510                 2515                 2520             


Asn Lys  Val Gln Glu Leu Lys  Asp Lys Leu Thr Glu  Leu Leu Glu 
    2525                 2530                 2535             


Glu Asn  Pro Asp Thr Pro Glu  Ala Pro Arg Trp Lys  Gln Met Leu 
    2540                 2545                 2550             


Thr Glu  Ile Asp Ser Lys Trp  Gln Glu Leu Asn Gln  Leu Thr Ile 
    2555                 2560                 2565             


Asp Arg  Gln Gln Lys Leu Glu  Glu Ser Ser Asn Asn  Leu Thr Gln 
    2570                 2575                 2580             


Phe Gln  Thr Val Glu Ala Gln  Leu Lys Gln Trp Leu  Val Glu Lys 
    2585                 2590                 2595             


Glu Leu  Met Val Ser Val Leu  Gly Pro Leu Ser Ile  Asp Pro Asn 
    2600                 2605                 2610             


Met Leu  Asn Thr Gln Arg Gln  Gln Val Gln Ile Leu  Leu Gln Glu 
    2615                 2620                 2625             


Phe Ala  Thr Arg Lys Pro Gln  Tyr Glu Gln Leu Thr  Ala Ala Gly 
    2630                 2635                 2640             


Gln Gly  Ile Leu Ser Arg Pro  Gly Glu Asp Pro Ser  Leu Arg Gly 
    2645                 2650                 2655             


Ile Val  Lys Glu Gln Leu Ala  Ala Val Thr Gln Lys  Trp Asp Ser 
    2660                 2665                 2670             


Leu Thr  Gly Gln Leu Ser Asp  Arg Cys Asp Trp Ile  Asp Gln Ala 
    2675                 2680                 2685             


Ile Val  Lys Ser Thr Gln Tyr  Gln Ser Leu Leu Arg  Ser Leu Ser 
    2690                 2695                 2700             


Asp Lys  Leu Ser Asp Leu Asp  Asn Lys Leu Ser Ser  Ser Leu Ala 
    2705                 2710                 2715             


Val Ser  Thr His Pro Asp Ala  Met Asn Gln Gln Leu  Glu Thr Ala 
    2720                 2725                 2730             


Gln Lys  Met Lys Gln Glu Ile  Gln Gln Glu Lys Lys  Gln Ile Lys 
    2735                 2740                 2745             


Val Ala  Gln Ala Leu Cys Glu  Asp Leu Ser Ala Leu  Val Lys Glu 
    2750                 2755                 2760             


Glu Tyr  Leu Lys Ala Glu Leu  Ser Arg Gln Leu Glu  Gly Ile Leu 
    2765                 2770                 2775             


Lys Ser  Phe Lys Asp Val Glu  Gln Lys Ala Glu Asn  His Val Gln 
    2780                 2785                 2790             


His Leu  Gln Ser Ala Cys Ala  Ser Ser His Gln Phe  Gln Gln Met 
    2795                 2800                 2805             


Ser Arg  Asp Phe Gln Ala Trp  Leu Asp Thr Lys Lys  Glu Glu Gln 
    2810                 2815                 2820             


Asn Lys  Ser His Pro Ile Ser  Ala Lys Leu Asp Val  Leu Glu Ser 
    2825                 2830                 2835             


Leu Ile  Lys Asp His Lys Asp  Phe Ser Lys Thr Leu  Thr Ala Gln 
    2840                 2845                 2850             


Ser His  Met Tyr Glu Lys Thr  Ile Ala Glu Gly Glu  Asn Leu Leu 
    2855                 2860                 2865             


Leu Lys  Thr Gln Gly Ser Glu  Lys Ala Ala Leu Gln  Leu Gln Leu 
    2870                 2875                 2880             


Asn Thr  Ile Lys Thr Asn Trp  Asp Thr Phe Asn Lys  Gln Val Lys 
    2885                 2890                 2895             


Glu Arg  Glu Asn Lys Leu Lys  Glu Ser Leu Glu Lys  Ala Leu Lys 
    2900                 2905                 2910             


Tyr Lys  Glu Gln Val Glu Thr  Leu Trp Pro Trp Ile  Asp Lys Cys 
    2915                 2920                 2925             


Gln Asn  Asn Leu Glu Glu Ile  Lys Phe Cys Leu Asp  Pro Ala Glu 
    2930                 2935                 2940             


Gly Glu  Asn Ser Ile Ala Lys  Leu Lys Ser Leu Gln  Lys Glu Met 
    2945                 2950                 2955             


Asp Gln  His Phe Gly Met Val  Glu Leu Leu Asn Asn  Thr Ala Asn 
    2960                 2965                 2970             


Ser Leu  Leu Ser Val Cys Glu  Ile Asp Lys Glu Val  Val Thr Asp 
    2975                 2980                 2985             


Glu Asn  Lys Ser Leu Ile Gln  Lys Val Asp Met Val  Thr Glu Gln 
    2990                 2995                 3000             


Leu His  Ser Lys Lys Phe Cys  Leu Glu Asn Met Thr  Gln Lys Phe 
    3005                 3010                 3015             


Lys Glu  Phe Gln Glu Val Ser  Lys Glu Ser Lys Arg  Gln Leu Gln 
    3020                 3025                 3030             


Cys Ala  Lys Glu Gln Leu Asp  Ile His Asp Ser Leu  Gly Ser Gln 
    3035                 3040                 3045             


Ala Tyr  Ser Asn Lys Tyr Leu  Thr Met Leu Gln Thr  Gln Gln Lys 
    3050                 3055                 3060             


Ser Leu  Gln Ala Leu Lys His  Gln Val Asp Leu Ala  Lys Arg Leu 
    3065                 3070                 3075             


Ala Gln  Asp Leu Val Val Glu  Ala Ser Asp Ser Lys  Gly Thr Ser 
    3080                 3085                 3090             


Asp Val  Leu Leu Gln Val Glu  Thr Ile Ala Gln Glu  His Ser Thr 
    3095                 3100                 3105             


Leu Ser  Gln Gln Val Asp Glu  Lys Cys Ser Phe Leu  Glu Thr Lys 
    3110                 3115                 3120             


Leu Gln  Gly Ile Gly His Phe  Gln Asn Thr Ile Arg  Glu Met Phe 
    3125                 3130                 3135             


Ser Gln  Phe Ala Glu Phe Asp  Asp Glu Leu Asp Ser  Met Ala Pro 
    3140                 3145                 3150             


Val Gly  Arg Asp Ala Glu Thr  Leu Gln Lys Gln Lys  Glu Thr Ile 
    3155                 3160                 3165             


Lys Ala  Phe Leu Lys Lys Leu  Glu Ala Leu Met Ala  Ser Asn Asp 
    3170                 3175                 3180             


Asn Ala  Asn Lys Thr Cys Lys  Met Met Leu Ala Thr  Glu Glu Thr 
    3185                 3190                 3195             


Ser Pro  Asp Leu Val Gly Ile  Lys Arg Asp Leu Glu  Ala Leu Ser 
    3200                 3205                 3210             


Lys Gln  Cys Asn Lys Leu Leu  Asp Arg Ala Gln Ala  Arg Glu Glu 
    3215                 3220                 3225             


Gln Val  Glu Gly Thr Ile Lys  Arg Leu Glu Glu Phe  Tyr Ser Lys 
    3230                 3235                 3240             


Leu Lys  Glu Phe Ser Ile Leu  Leu Gln Lys Ala Glu  Glu His Glu 
    3245                 3250                 3255             


Glu Ser  Gln Gly Pro Val Gly  Met Glu Thr Glu Thr  Ile Asn Gln 
    3260                 3265                 3270             


Gln Leu  Asn Met Phe Lys Val  Phe Gln Lys Glu Glu  Ile Glu Pro 
    3275                 3280                 3285             


Leu Gln  Gly Lys Gln Gln Asp  Val Asn Trp Leu Gly  Gln Gly Leu 
    3290                 3295                 3300             


Ile Gln  Ser Ala Ala Lys Ser  Thr Ser Thr Gln Gly  Leu Glu His 
    3305                 3310                 3315             


Asp Leu  Asp Asp Val Asn Ala  Arg Trp Lys Thr Leu  Asn Lys Lys 
    3320                 3325                 3330             


Val Ala  Gln Arg Ala Ala Gln  Leu Gln Glu Ala Leu  Leu His Cys 
    3335                 3340                 3345             


Gly Arg  Phe Gln Asp Ala Leu  Glu Ser Leu Leu Ser  Trp Met Val 
    3350                 3355                 3360             


Asp Thr  Glu Glu Leu Val Ala  Asn Gln Lys Pro Pro  Ser Ala Glu 
    3365                 3370                 3375             


Phe Lys  Val Val Lys Ala Gln  Ile Gln Glu Gln Lys  Leu Leu Gln 
    3380                 3385                 3390             


Arg Leu  Leu Asp Asp Arg Lys  Ser Thr Val Glu Val  Ile Lys Arg 
    3395                 3400                 3405             


Glu Gly  Glu Lys Ile Ala Thr  Thr Ala Glu Pro Ala  Asp Lys Val 
    3410                 3415                 3420             


Lys Ile  Leu Lys Gln Leu Ser  Leu Leu Asp Ser Arg  Trp Glu Ala 
    3425                 3430                 3435             


Leu Leu  Asn Lys Ala Glu Thr  Arg Asn Arg Gln Leu  Glu Gly Ile 
    3440                 3445                 3450             


Ser Val  Val Ala Gln Gln Phe  His Glu Thr Leu Glu  Pro Leu Asn 
    3455                 3460                 3465             


Glu Trp  Leu Thr Thr Ile Glu  Lys Arg Leu Val Asn  Cys Glu Pro 
    3470                 3475                 3480             


Ile Gly  Thr Gln Ala Ser Lys  Leu Glu Glu Gln Ile  Ala Gln His 
    3485                 3490                 3495             


Lys Ala  Leu Glu Asp Asp Ile  Ile Asn His Asn Lys  His Leu His 
    3500                 3505                 3510             


Gln Ala  Val Ser Ile Gly Gln  Ser Leu Lys Val Leu  Ser Ser Arg 
    3515                 3520                 3525             


Glu Asp  Lys Asp Met Val Gln  Ser Lys Leu Asp Phe  Ser Gln Val 
    3530                 3535                 3540             


Trp Tyr  Ile Glu Ile Gln Glu  Lys Ser His Ser Arg  Ser Glu Leu 
    3545                 3550                 3555             


Leu Gln  Gln Ala Leu Cys Asn  Ala Lys Ile Phe Gly  Glu Asp Glu 
    3560                 3565                 3570             


Val Glu  Leu Met Asn Trp Leu  Asn Glu Val His Asp  Lys Leu Ser 
    3575                 3580                 3585             


Lys Leu  Ser Val Gln Asp Tyr  Ser Thr Glu Gly Leu  Trp Lys Gln 
    3590                 3595                 3600             


Gln Ser  Glu Leu Arg Val Leu  Gln Glu Asp Ile Leu  Leu Arg Lys 
    3605                 3610                 3615             


Gln Asn  Val Asp Gln Ala Leu  Leu Asn Gly Leu Glu  Leu Leu Lys 
    3620                 3625                 3630             


Gln Thr  Thr Gly Asp Glu Val  Leu Ile Ile Gln Asp  Lys Leu Glu 
    3635                 3640                 3645             


Ala Ile  Lys Ala Arg Tyr Lys  Asp Ile Thr Lys Leu  Ser Thr Asp 
    3650                 3655                 3660             


Val Ala  Lys Thr Leu Glu Gln  Ala Leu Gln Leu Ala  Arg Arg Leu 
    3665                 3670                 3675             


His Ser  Thr His Glu Glu Leu  Cys Thr Trp Leu Asp  Lys Val Glu 
    3680                 3685                 3690             


Val Glu  Leu Leu Ser Tyr Glu  Thr Gln Val Leu Lys  Gly Glu Glu 
    3695                 3700                 3705             


Ala Ser  Gln Ala Gln Met Arg  Pro Lys Glu Leu Lys  Lys Glu Ala 
    3710                 3715                 3720             


Lys Asn  Asn Lys Ala Leu Leu  Asp Ser Leu Asn Glu  Val Ser Ser 
    3725                 3730                 3735             


Ala Leu  Leu Glu Leu Val Pro  Trp Arg Ala Arg Glu  Gly Leu Glu 
    3740                 3745                 3750             


Lys Met  Val Ala Glu Asp Asn  Glu Arg Tyr Arg Leu  Val Ser Asp 
    3755                 3760                 3765             


Thr Ile  Thr Gln Lys Val Glu  Glu Ile Asp Ala Ala  Ile Leu Arg 
    3770                 3775                 3780             


Ser Gln  Gln Phe Asp Gln Ala  Ala Asp Ala Glu Leu  Ser Trp Ile 
    3785                 3790                 3795             


Thr Glu  Thr Glu Lys Lys Leu  Met Ser Leu Gly Asp  Ile Arg Leu 
    3800                 3805                 3810             


Glu Gln  Asp Gln Thr Ser Ala  Gln Leu Gln Val Gln  Lys Thr Phe 
    3815                 3820                 3825             


Thr Met  Glu Ile Leu Arg His  Lys Asp Ile Ile Asp  Asp Leu Val 
    3830                 3835                 3840             


Lys Ser  Gly His Lys Ile Met  Thr Ala Cys Ser Glu  Glu Glu Lys 
    3845                 3850                 3855             


Gln Ser  Met Lys Lys Lys Leu  Asp Lys Val Leu Lys  Asn Tyr Asp 
    3860                 3865                 3870             


Thr Ile  Cys Gln Ile Asn Ser  Glu Arg Tyr Leu Gln  Leu Glu Arg 
    3875                 3880                 3885             


Ala Gln  Ser Leu Val Asn Gln  Phe Trp Glu Thr Tyr  Glu Glu Leu 
    3890                 3895                 3900             


Trp Pro  Trp Leu Thr Glu Thr  Gln Ser Ile Ile Ser  Gln Leu Pro 
    3905                 3910                 3915             


Ala Pro  Ala Leu Glu Tyr Glu  Thr Leu Arg Gln Gln  Gln Glu Glu 
    3920                 3925                 3930             


His Arg  Gln Leu Arg Glu Leu  Ile Ala Glu His Lys  Pro His Ile 
    3935                 3940                 3945             


Asp Lys  Met Asn Lys Thr Gly  Pro Gln Leu Leu Glu  Leu Ser Pro 
    3950                 3955                 3960             


Gly Glu  Gly Phe Ser Ile Gln  Glu Lys Tyr Val Ala  Ala Asp Thr 
    3965                 3970                 3975             


Leu Tyr  Ser Gln Ile Lys Glu  Asp Val Lys Lys Arg  Ala Val Ala 
    3980                 3985                 3990             


Leu Asp  Glu Ala Ile Ser Gln  Ser Thr Gln Phe His  Asp Lys Ile 
    3995                 4000                 4005             


Asp Gln  Ile Leu Glu Ser Leu  Glu Arg Ile Val Glu  Arg Leu Arg 
    4010                 4015                 4020             


Gln Pro  Pro Ser Ile Ser Ala  Glu Val Glu Lys Ile  Lys Glu Gln 
    4025                 4030                 4035             


Ile Ser  Glu Asn Lys Asn Val  Ser Val Asp Met Glu  Lys Leu Gln 
    4040                 4045                 4050             


Pro Leu  Tyr Glu Thr Leu Lys  Gln Arg Gly Glu Glu  Met Ile Ala 
    4055                 4060                 4065             


Arg Ser  Gly Gly Thr Asp Lys  Asp Ile Ser Ala Lys  Ala Val Gln 
    4070                 4075                 4080             


Asp Lys  Leu Asp Gln Met Val  Phe Ile Trp Glu Asn  Ile His Thr 
    4085                 4090                 4095             


Leu Val  Glu Glu Arg Glu Ala  Lys Leu Leu Asp Val  Met Glu Leu 
    4100                 4105                 4110             


Ala Glu  Lys Phe Trp Cys Asp  His Met Ser Leu Ile  Val Thr Ile 
    4115                 4120                 4125             


Lys Asp  Thr Gln Asp Phe Ile  Arg Asp Leu Glu Asp  Pro Gly Ile 
    4130                 4135                 4140             


Asp Pro  Ser Val Val Lys Gln  Gln Gln Glu Ala Ala  Glu Thr Ile 
    4145                 4150                 4155             


Arg Glu  Glu Ile Asp Gly Leu  Gln Glu Glu Leu Asp  Ile Val Ile 
    4160                 4165                 4170             


Asn Leu  Gly Ser Glu Leu Ile  Ala Ala Cys Gly Glu  Pro Asp Lys 
    4175                 4180                 4185             


Pro Ile  Val Lys Lys Ser Ile  Asp Glu Leu Asn Ser  Ala Trp Asp 
    4190                 4195                 4200             


Ser Leu  Asn Lys Ala Trp Lys  Asp Arg Ile Asp Lys  Leu Glu Glu 
    4205                 4210                 4215             


Ala Met  Gln Ala Ala Val Gln  Tyr Gln Asp Gly Leu  Gln Ala Val 
    4220                 4225                 4230             


Phe Asp  Trp Val Asp Ile Ala  Gly Gly Lys Leu Ala  Ser Met Ser 
    4235                 4240                 4245             


Pro Ile  Gly Thr Asp Leu Glu  Thr Val Lys Gln Gln  Ile Glu Glu 
    4250                 4255                 4260             


Leu Lys  Gln Phe Lys Ser Glu  Ala Tyr Gln Gln Gln  Ile Glu Met 
    4265                 4270                 4275             


Glu Arg  Leu Asn His Gln Ala  Glu Leu Leu Leu Lys  Lys Val Thr 
    4280                 4285                 4290             


Glu Glu  Ser Asp Lys His Thr  Val Gln Asp Pro Leu  Met Glu Leu 
    4295                 4300                 4305             


Lys Leu  Ile Trp Asp Ser Leu  Glu Glu Arg Ile Ile  Asn Arg Gln 
    4310                 4315                 4320             


His Lys  Leu Glu Gly Ala Leu  Leu Ala Leu Gly Gln  Phe Gln His 
    4325                 4330                 4335             


Ala Leu  Asp Glu Leu Leu Ala  Trp Leu Thr His Thr  Glu Gly Leu 
    4340                 4345                 4350             


Leu Ser  Glu Gln Lys Pro Val  Gly Gly Asp Pro Lys  Ala Ile Glu 
    4355                 4360                 4365             


Ile Glu  Leu Ala Lys His His  Val Leu Gln Asn Asp  Val Leu Ala 
    4370                 4375                 4380             


His Gln  Ser Thr Val Glu Ala  Val Asn Lys Ala Gly  Asn Asp Leu 
    4385                 4390                 4395             


Ile Glu  Ser Ser Ala Gly Glu  Glu Ala Ser Asn Leu  Gln Asn Lys 
    4400                 4405                 4410             


Leu Glu  Val Leu Asn Gln Arg  Trp Gln Asn Val Leu  Glu Lys Thr 
    4415                 4420                 4425             


Glu Gln  Arg Lys Gln Gln Leu  Asp Gly Ala Leu Arg  Gln Ala Lys 
    4430                 4435                 4440             


Gly Phe  His Gly Glu Ile Glu  Asp Leu Gln Gln Trp  Leu Thr Asp 
    4445                 4450                 4455             


Thr Glu  Arg His Leu Leu Ala  Ser Lys Pro Leu Gly  Gly Leu Pro 
    4460                 4465                 4470             


Glu Thr  Ala Lys Glu Gln Leu  Asn Val His Met Glu  Val Cys Ala 
    4475                 4480                 4485             


Ala Phe  Glu Ala Lys Glu Glu  Thr Tyr Lys Ser Leu  Met Gln Lys 
    4490                 4495                 4500             


Gly Gln  Gln Met Leu Ala Arg  Cys Pro Lys Ser Ala  Glu Thr Asn 
    4505                 4510                 4515             


Ile Asp  Gln Asp Ile Asn Asn  Leu Lys Glu Lys Trp  Glu Ser Val 
    4520                 4525                 4530             


Glu Thr  Lys Leu Asn Glu Arg  Lys Thr Lys Leu Glu  Glu Ala Leu 
    4535                 4540                 4545             


Asn Leu  Ala Met Glu Phe His  Asn Ser Leu Gln Asp  Phe Ile Asn 
    4550                 4555                 4560             


Trp Leu  Thr Gln Ala Glu Gln  Thr Leu Asn Val Ala  Ser Arg Pro 
    4565                 4570                 4575             


Ser Leu  Ile Leu Asp Thr Val  Leu Phe Gln Ile Asp  Glu His Lys 
    4580                 4585                 4590             


Val Phe  Ala Asn Glu Val Asn  Ser His Arg Glu Gln  Ile Ile Glu 
    4595                 4600                 4605             


Leu Asp  Lys Thr Gly Thr His  Leu Lys Tyr Phe Ser  Gln Lys Gln 
    4610                 4615                 4620             


Asp Val  Val Leu Ile Lys Asn  Leu Leu Ile Ser Val  Gln Ser Arg 
    4625                 4630                 4635             


Trp Glu  Lys Val Val Gln Arg  Leu Val Glu Arg Gly  Arg Ser Leu 
    4640                 4645                 4650             


Asp Asp  Ala Arg Lys Arg Ala  Lys Gln Phe His Glu  Ala Trp Ser 
    4655                 4660                 4665             


Lys Leu  Met Glu Trp Leu Glu  Glu Ser Glu Lys Ser  Leu Asp Ser 
    4670                 4675                 4680             


Glu Leu  Glu Ile Ala Asn Asp  Pro Asp Lys Ile Lys  Thr Gln Leu 
    4685                 4690                 4695             


Ala Gln  His Lys Glu Phe Gln  Lys Ser Leu Gly Ala  Lys His Ser 
    4700                 4705                 4710             


Val Tyr  Asp Thr Thr Asn Arg  Thr Gly Arg Ser Leu  Lys Glu Lys 
    4715                 4720                 4725             


Thr Ser  Leu Ala Asp Asp Asn  Leu Lys Leu Asp Asp  Met Leu Ser 
    4730                 4735                 4740             


Glu Leu  Arg Asp Lys Trp Asp  Thr Ile Cys Gly Lys  Ser Val Glu 
    4745                 4750                 4755             


Arg Gln  Asn Lys Leu Glu Glu  Ala Leu Leu Phe Ser  Gly Gln Phe 
    4760                 4765                 4770             


Thr Asp  Ala Leu Gln Ala Leu  Ile Asp Trp Leu Tyr  Arg Val Glu 
    4775                 4780                 4785             


Pro Gln  Leu Ala Glu Asp Gln  Pro Val His Gly Asp  Ile Asp Leu 
    4790                 4795                 4800             


Val Met  Asn Leu Ile Asp Asn  His Lys Ala Phe Gln  Lys Glu Leu 
    4805                 4810                 4815             


Gly Lys  Arg Thr Ser Ser Val  Gln Ala Leu Lys Arg  Ser Ala Arg 
    4820                 4825                 4830             


Glu Leu  Ile Glu Gly Ser Arg  Asp Asp Ser Ser Trp  Val Lys Val 
    4835                 4840                 4845             


Gln Met  Gln Glu Leu Ser Thr  Arg Trp Glu Thr Val  Cys Ala Leu 
    4850                 4855                 4860             


Ser Ile  Ser Lys Gln Thr Arg  Leu Glu Ala Ala Leu  Arg Gln Ala 
    4865                 4870                 4875             


Glu Glu  Phe His Ser Val Val  His Ala Leu Leu Glu  Trp Leu Ala 
    4880                 4885                 4890             


Glu Ala  Glu Gln Thr Leu Arg  Phe His Gly Val Leu  Pro Asp Asp 
    4895                 4900                 4905             


Glu Asp  Ala Leu Arg Thr Leu  Ile Asp Gln His Lys  Glu Phe Met 
    4910                 4915                 4920             


Lys Lys  Leu Glu Glu Lys Arg  Ala Glu Leu Asn Lys  Ala Thr Thr 
    4925                 4930                 4935             


Met Gly  Asp Thr Val Leu Ala  Ile Cys His Pro Asp  Ser Ile Thr 
    4940                 4945                 4950             


Thr Ile  Lys His Trp Ile Thr  Ile Ile Arg Ala Arg  Phe Glu Glu 
    4955                 4960                 4965             


Val Leu  Ala Trp Ala Lys Gln  His Gln Gln Arg Leu  Ala Ser Ala 
    4970                 4975                 4980             


Leu Ala  Gly Leu Ile Ala Lys  Gln Glu Leu Leu Glu  Ala Leu Leu 
    4985                 4990                 4995             


Ala Trp  Leu Gln Trp Ala Glu  Thr Thr Leu Thr Asp  Lys Asp Lys 
    5000                 5005                 5010             


Glu Val  Ile Pro Gln Glu Ile  Glu Glu Val Lys Ala  Leu Ile Ala 
    5015                 5020                 5025             


Glu His  Gln Thr Phe Met Glu  Glu Met Thr Arg Lys  Gln Pro Asp 
    5030                 5035                 5040             


Val Asp  Lys Val Thr Lys Thr  Tyr Lys Arg Arg Ala  Ala Asp Pro 
    5045                 5050                 5055             


Ser Ser  Leu Gln Ser His Ile  Pro Val Leu Asp Lys  Gly Arg Ala 
    5060                 5065                 5070             


Gly Arg  Lys Arg Phe Pro Ala  Ser Ser Leu Tyr Pro  Ser Gly Ser 
    5075                 5080                 5085             


Gln Thr  Gln Ile Glu Thr Lys  Asn Pro Arg Val Asn  Leu Leu Val 
    5090                 5095                 5100             


Ser Lys  Trp Gln Gln Val Trp  Leu Leu Ala Leu Glu  Arg Arg Arg 
    5105                 5110                 5115             


Lys Leu  Asn Asp Ala Leu Asp  Arg Leu Glu Glu Leu  Arg Glu Phe 
    5120                 5125                 5130             


Ala Asn  Phe Asp Phe Asp Ile  Trp Arg Lys Lys Tyr  Met Arg Trp 
    5135                 5140                 5145             


Met Asn  His Lys Lys Ser Arg  Val Met Asp Phe Phe  Arg Arg Ile 
    5150                 5155                 5160             


Asp Lys  Asp Gln Asp Gly Lys  Ile Thr Arg Gln Glu  Phe Ile Asp 
    5165                 5170                 5175             


Gly Ile  Leu Ser Ser Lys Phe  Pro Thr Ser Arg Leu  Glu Met Ser 
    5180                 5185                 5190             


Ala Val  Ala Asp Ile Phe Asp  Arg Asp Gly Asp Gly  Tyr Ile Asp 
    5195                 5200                 5205             


Tyr Tyr  Glu Phe Val Ala Ala  Leu His Pro Asn Lys  Asp Ala Tyr 
    5210                 5215                 5220             


Lys Pro  Ile Thr Asp Ala Asp  Lys Ile Glu Asp Glu  Val Thr Arg 
    5225                 5230                 5235             


Gln Val  Ala Lys Cys Lys Cys  Ala Lys Arg Phe Gln  Val Glu Gln 
    5240                 5245                 5250             


Ile Gly  Asp Asn Lys Tyr Arg  Phe Phe Leu Gly Asn  Gln Phe Gly 
    5255                 5260                 5265             


Asp Ser  Gln Gln Leu Arg Leu  Val Arg Ile Leu Arg  Ser Thr Val 
    5270                 5275                 5280             


Met Val  Arg Val Gly Gly Gly  Trp Met Ala Leu Asp  Glu Phe Leu 
    5285                 5290                 5295             


Val Lys  Asn Asp Pro Cys Arg  Ala Lys Gly Arg Thr  Asn Met Glu 
    5300                 5305                 5310             


Leu Arg  Glu Lys Phe Ile Leu  Ala Asp Gly Ala Ser  Gln Gly Met 
    5315                 5320                 5325             


Ala Ala  Phe Arg Pro Arg Gly  Arg Arg Ser Arg Pro  Ser Ser Arg 
    5330                 5335                 5340             


Gly Ala  Ser Pro Asn Arg Ser  Thr Ser Val Ser Ser  Gln Ala Ala 
    5345                 5350                 5355             


Gln Ala  Ala Ser Pro Gln Val  Pro Ala Thr Thr Thr  Pro Lys Ile 
    5360                 5365                 5370             


Leu His  Pro Leu Thr Arg Asn  Tyr Gly Lys Pro Trp  Leu Thr Asn 
    5375                 5380                 5385             


Ser Lys  Met Ser Thr Pro Cys  Lys Ala Ala Glu Cys  Ser Asp Phe 
    5390                 5395                 5400             


Pro Val  Pro Ser Ala Glu Gly  Thr Pro Ile Gln Gly  Ser Lys Leu 
    5405                 5410                 5415             


Arg Leu  Pro Gly Tyr Leu Ser  Gly Lys Gly Phe His  Ser Gly Glu 
    5420                 5425                 5430             


Asp Ser  Gly Leu Ile Thr Thr  Ala Ala Ala Arg Val  Arg Thr Gln 
    5435                 5440                 5445             


Phe Ala  Asp Ser Lys Lys Thr  Pro Ser Arg Pro Gly  Ser Arg Ala 
    5450                 5455                 5460             


Gly Ser  Lys Ala Gly Ser Arg  Ala Ser Ser Arg Arg  Gly Ser Asp 
    5465                 5470                 5475             


Ala Ser  Asp Phe Asp Ile Ser  Glu Ile Gln Ser Val  Cys Ser Asp 
    5480                 5485                 5490             


Val Glu  Thr Val Pro Gln Thr  His Arg Pro Thr Pro  Arg Ala Gly 
    5495                 5500                 5505             


Ser Arg  Pro Ser Thr Ala Lys  Pro Ser Lys Ile Pro  Thr Pro Gln 
    5510                 5515                 5520             


Arg Lys  Ser Pro Ala Ser Lys  Leu Asp Lys Ser Ser  Lys Arg 
    5525                 5530                 5535         


<210>  1774
<211>  5675
<212>  PRT
<213>  Homo sapiens

<400>  1774

Met Ile Ala Ala Ala Phe Leu Val Leu Leu Arg Pro Tyr Ser Ile Gln 
1               5                   10                  15      


Cys Ala Leu Phe Leu Leu Leu Leu Leu Leu Gly Thr Ile Ala Thr Ile 
            20                  25                  30          


Val Phe Phe Cys Cys Trp His Arg Lys Leu Gln Lys Gly Arg His Pro 
        35                  40                  45              


Met Lys Ser Val Phe Ser Gly Arg Ser Arg Ser Arg Asp Ala Val Leu 
    50                  55                  60                  


Arg Ser His His Phe Arg Ser Glu Gly Phe Arg Ala Ser Pro Arg His 
65                  70                  75                  80  


Leu Arg Arg Arg Val Ala Ala Ala Ala Ala Ala Arg Leu Glu Glu Val 
                85                  90                  95      


Lys Pro Val Val Glu Val His His Gln Ser Glu Gln Glu Thr Ser Val 
            100                 105                 110         


Arg Lys Arg Arg Ile Lys Lys Ser Ser Arg Val Gln Pro Glu Phe Tyr 
        115                 120                 125             


His Ser Val Gln Gly Ala Ser Ile Arg Arg Pro Ser Ser Gly Asn Ala 
    130                 135                 140                 


Ser Tyr Arg Cys Ser Met Ser Ser Ser Ala Asp Phe Ser Asp Glu Asp 
145                 150                 155                 160 


Asp Phe Ser Gln Lys Ser Gly Ser Ala Ser Pro Ala Pro Gly Asp Thr 
                165                 170                 175     


Leu Pro Trp Asn Leu Pro Lys His Glu Arg Ser Lys Arg Lys Ile Gln 
            180                 185                 190         


Gly Gly Ser Val Leu Asp Pro Ala Glu Arg Ala Val Leu Arg Ile Ala 
        195                 200                 205             


Asp Glu Arg Asp Lys Val Gln Lys Lys Thr Phe Thr Lys Trp Ile Asn 
    210                 215                 220                 


Gln His Leu Met Lys Val Arg Lys His Val Asn Asp Leu Tyr Glu Asp 
225                 230                 235                 240 


Leu Arg Asp Gly His Asn Leu Ile Ser Leu Leu Glu Val Leu Ser Gly 
                245                 250                 255     


Asp Thr Leu Pro Arg Glu Lys Gly Arg Met Arg Phe His Arg Leu Gln 
            260                 265                 270         


Asn Val Gln Ile Ala Leu Asp Tyr Leu Lys Arg Arg Gln Val Lys Leu 
        275                 280                 285             


Val Asn Ile Arg Asn Asp Asp Ile Thr Asp Gly Asn Pro Lys Leu Thr 
    290                 295                 300                 


Leu Gly Leu Ile Trp Thr Ile Ile Leu His Phe Gln Ile Ser Asp Ile 
305                 310                 315                 320 


His Val Thr Gly Glu Ser Glu Asp Met Ser Ala Lys Glu Arg Leu Leu 
                325                 330                 335     


Leu Trp Thr Gln Gln Ala Thr Glu Gly Tyr Ala Gly Ile Arg Cys Glu 
            340                 345                 350         


Asn Phe Thr Thr Cys Trp Arg Asp Gly Lys Leu Phe Asn Ala Ile Ile 
        355                 360                 365             


His Lys Tyr Arg Pro Asp Leu Ile Asp Met Asn Thr Val Ala Val Gln 
    370                 375                 380                 


Ser Asn Leu Ala Asn Leu Glu His Ala Phe Tyr Val Ala Glu Lys Ile 
385                 390                 395                 400 


Gly Val Ile Arg Leu Leu Asp Pro Glu Asp Val Asp Val Ser Ser Pro 
                405                 410                 415     


Asp Glu Lys Ser Val Ile Thr Tyr Val Ser Ser Leu Tyr Asp Ala Phe 
            420                 425                 430         


Pro Lys Val Pro Glu Gly Gly Glu Gly Ile Gly Ala Asn Asp Val Glu 
        435                 440                 445             


Val Lys Trp Ile Glu Tyr Gln Asn Met Val Asn Tyr Leu Ile Gln Trp 
    450                 455                 460                 


Ile Arg His His Val Thr Thr Met Ser Glu Arg Thr Phe Pro Asn Asn 
465                 470                 475                 480 


Pro Val Glu Leu Lys Ala Leu Tyr Asn Gln Tyr Leu Gln Phe Lys Glu 
                485                 490                 495     


Thr Glu Ile Pro Pro Lys Glu Thr Glu Lys Ser Lys Ile Lys Arg Leu 
            500                 505                 510         


Tyr Lys Leu Leu Glu Ile Trp Ile Glu Phe Gly Arg Ile Lys Leu Leu 
        515                 520                 525             


Gln Gly Tyr His Pro Asn Asp Ile Glu Lys Glu Trp Gly Lys Leu Ile 
    530                 535                 540                 


Ile Ala Met Leu Glu Arg Glu Lys Ala Leu Arg Pro Glu Val Glu Arg 
545                 550                 555                 560 


Leu Glu Met Leu Gln Gln Ile Ala Asn Arg Val Gln Arg Asp Ser Val 
                565                 570                 575     


Ile Cys Glu Asp Lys Leu Ile Leu Ala Gly Asn Ala Leu Gln Ser Asp 
            580                 585                 590         


Ser Lys Arg Leu Glu Ser Gly Val Gln Phe Gln Asn Glu Ala Glu Ile 
        595                 600                 605             


Ala Gly Tyr Ile Leu Glu Cys Glu Asn Leu Leu Arg Gln His Val Ile 
    610                 615                 620                 


Asp Val Gln Ile Leu Ile Asp Gly Lys Tyr Tyr Gln Ala Asp Gln Leu 
625                 630                 635                 640 


Val Gln Arg Val Ala Lys Leu Arg Asp Glu Ile Met Ala Leu Arg Asn 
                645                 650                 655     


Glu Cys Ser Ser Val Tyr Ser Lys Gly Arg Ile Leu Thr Thr Glu Gln 
            660                 665                 670         


Thr Lys Leu Met Ile Ser Gly Ile Thr Gln Ser Leu Asn Ser Gly Phe 
        675                 680                 685             


Ala Gln Thr Leu His Pro Ser Leu Thr Ser Gly Leu Thr Gln Ser Leu 
    690                 695                 700                 


Thr Pro Ser Leu Thr Ser Ser Ser Met Thr Ser Gly Leu Ser Ser Gly 
705                 710                 715                 720 


Met Thr Ser Arg Leu Thr Pro Ser Val Thr Pro Ala Tyr Thr Pro Gly 
                725                 730                 735     


Phe Pro Ser Gly Leu Val Pro Asn Phe Ser Ser Gly Val Glu Pro Asn 
            740                 745                 750         


Ser Leu Gln Thr Leu Lys Leu Met Gln Ile Arg Lys Pro Leu Leu Lys 
        755                 760                 765             


Ser Ser Leu Leu Asp Gln Asn Leu Thr Glu Glu Glu Ile Asn Met Lys 
    770                 775                 780                 


Phe Val Gln Asp Leu Leu Asn Trp Val Asp Glu Met Gln Val Gln Leu 
785                 790                 795                 800 


Asp Arg Thr Glu Trp Gly Ser Asp Leu Pro Ser Val Glu Ser His Leu 
                805                 810                 815     


Glu Asn His Lys Asn Val His Arg Ala Ile Glu Glu Phe Glu Ser Ser 
            820                 825                 830         


Leu Lys Glu Ala Lys Ile Ser Glu Ile Gln Met Thr Ala Pro Leu Lys 
        835                 840                 845             


Leu Thr Tyr Ala Glu Lys Leu His Arg Leu Glu Ser Gln Tyr Ala Lys 
    850                 855                 860                 


Leu Leu Asn Thr Ser Arg Asn Gln Glu Arg His Leu Asp Thr Leu His 
865                 870                 875                 880 


Asn Phe Val Ser Arg Ala Thr Asn Glu Leu Ile Trp Leu Asn Glu Lys 
                885                 890                 895     


Glu Glu Glu Glu Val Ala Tyr Asp Trp Ser Glu Arg Asn Thr Asn Ile 
            900                 905                 910         


Ala Arg Lys Lys Asp Tyr His Ala Glu Leu Met Arg Glu Leu Asp Gln 
        915                 920                 925             


Lys Glu Glu Asn Ile Lys Ser Val Gln Glu Ile Ala Glu Gln Leu Leu 
    930                 935                 940                 


Leu Glu Asn His Pro Ala Arg Leu Thr Ile Glu Ala Tyr Arg Ala Ala 
945                 950                 955                 960 


Met Gln Thr Gln Trp Ser Trp Ile Leu Gln Leu Cys Gln Cys Val Glu 
                965                 970                 975     


Gln His Ile Lys Glu Asn Thr Ala Tyr Phe Glu Phe Phe Asn Asp Ala 
            980                 985                 990         


Lys Glu Ala Thr Asp Tyr Leu Arg  Asn Leu Lys Asp Ala  Ile Gln Arg 
        995                 1000                 1005             


Lys Tyr  Ser Cys Asp Arg Ser  Ser Ser Ile His Lys  Leu Glu Asp 
    1010                 1015                 1020             


Leu Val  Gln Glu Ser Met Glu  Glu Lys Glu Glu Leu  Leu Gln Tyr 
    1025                 1030                 1035             


Lys Ser  Thr Ile Ala Asn Leu  Met Gly Lys Ala Lys  Thr Ile Ile 
    1040                 1045                 1050             


Gln Leu  Lys Pro Arg Asn Ser  Asp Cys Pro Leu Lys  Thr Ser Ile 
    1055                 1060                 1065             


Pro Ile  Lys Ala Ile Cys Asp  Tyr Arg Gln Ile Glu  Ile Thr Ile 
    1070                 1075                 1080             


Tyr Lys  Asp Asp Glu Cys Val  Leu Ala Asn Asn Ser  His Arg Ala 
    1085                 1090                 1095             


Lys Trp  Lys Val Ile Ser Pro  Thr Gly Asn Glu Ala  Met Val Pro 
    1100                 1105                 1110             


Ser Val  Cys Phe Thr Val Pro  Pro Pro Asn Lys Glu  Ala Val Asp 
    1115                 1120                 1125             


Leu Ala  Asn Arg Ile Glu Gln  Gln Tyr Gln Asn Val  Leu Thr Leu 
    1130                 1135                 1140             


Trp His  Glu Ser His Ile Asn  Met Lys Ser Val Val  Ser Trp His 
    1145                 1150                 1155             


Tyr Leu  Ile Asn Glu Ile Asp  Arg Ile Arg Ala Ser  Asn Val Ala 
    1160                 1165                 1170             


Ser Ile  Lys Thr Met Leu Pro  Gly Glu His Gln Gln  Val Leu Ser 
    1175                 1180                 1185             


Asn Leu  Gln Ser Arg Phe Glu  Asp Phe Leu Glu Asp  Ser Gln Glu 
    1190                 1195                 1200             


Ser Gln  Val Phe Ser Gly Ser  Asp Ile Thr Gln Leu  Glu Lys Glu 
    1205                 1210                 1215             


Val Asn  Val Cys Lys Gln Tyr  Tyr Gln Glu Leu Leu  Lys Ser Ala 
    1220                 1225                 1230             


Glu Arg  Glu Glu Gln Glu Glu  Ser Val Tyr Asn Leu  Tyr Ile Ser 
    1235                 1240                 1245             


Glu Val  Arg Asn Ile Arg Leu  Arg Leu Glu Asn Cys  Glu Asp Arg 
    1250                 1255                 1260             


Leu Ile  Arg Gln Ile Arg Thr  Pro Leu Glu Arg Asp  Asp Leu His 
    1265                 1270                 1275             


Glu Ser  Val Phe Arg Ile Thr  Glu Gln Glu Lys Leu  Lys Lys Glu 
    1280                 1285                 1290             


Leu Glu  Arg Leu Lys Asp Asp  Leu Gly Thr Ile Thr  Asn Lys Cys 
    1295                 1300                 1305             


Glu Glu  Phe Phe Ser Gln Ala  Ala Ala Ser Ser Ser  Val Pro Thr 
    1310                 1315                 1320             


Leu Arg  Ser Glu Leu Asn Val  Val Leu Gln Asn Met  Asn Gln Val 
    1325                 1330                 1335             


Tyr Ser  Met Ser Ser Thr Tyr  Ile Asp Lys Leu Lys  Thr Val Asn 
    1340                 1345                 1350             


Leu Val  Leu Lys Asn Thr Gln  Ala Ala Glu Ala Leu  Val Lys Leu 
    1355                 1360                 1365             


Tyr Glu  Thr Lys Leu Cys Glu  Glu Glu Ala Val Ile  Ala Asp Lys 
    1370                 1375                 1380             


Asn Asn  Ile Glu Asn Leu Ile  Ser Thr Leu Lys Gln  Trp Arg Ser 
    1385                 1390                 1395             


Glu Val  Asp Glu Lys Arg Gln  Val Phe His Ala Leu  Glu Asp Glu 
    1400                 1405                 1410             


Leu Gln  Lys Ala Lys Ala Ile  Ser Asp Glu Met Phe  Lys Thr Tyr 
    1415                 1420                 1425             


Lys Glu  Arg Asp Leu Asp Phe  Asp Trp His Lys Glu  Lys Ala Asp 
    1430                 1435                 1440             


Gln Leu  Val Glu Arg Trp Gln  Asn Val His Val Gln  Ile Asp Asn 
    1445                 1450                 1455             


Arg Leu  Arg Asp Leu Glu Gly  Ile Gly Lys Ser Leu  Lys Tyr Tyr 
    1460                 1465                 1470             


Arg Asp  Thr Tyr His Pro Leu  Asp Asp Trp Ile Gln  Gln Val Glu 
    1475                 1480                 1485             


Thr Thr  Gln Arg Lys Ile Gln  Glu Asn Gln Pro Glu  Asn Ser Lys 
    1490                 1495                 1500             


Thr Leu  Ala Thr Gln Leu Asn  Gln Gln Lys Met Leu  Val Ser Glu 
    1505                 1510                 1515             


Ile Glu  Met Lys Gln Ser Lys  Met Asp Glu Cys Gln  Lys Tyr Ala 
    1520                 1525                 1530             


Glu Gln  Tyr Ser Ala Thr Val  Lys Asp Tyr Glu Leu  Gln Thr Met 
    1535                 1540                 1545             


Thr Tyr  Arg Ala Met Val Asp  Ser Gln Gln Lys Ser  Pro Val Lys 
    1550                 1555                 1560             


Arg Arg  Arg Met Gln Ser Ser  Ala Asp Leu Ile Ile  Gln Glu Phe 
    1565                 1570                 1575             


Met Asp  Leu Arg Thr Arg Tyr  Thr Ala Leu Val Thr  Leu Met Thr 
    1580                 1585                 1590             


Gln Tyr  Ile Lys Phe Ala Gly  Asp Ser Leu Lys Arg  Leu Glu Glu 
    1595                 1600                 1605             


Glu Glu  Lys Ser Leu Glu Glu  Glu Lys Lys Glu His  Val Glu Lys 
    1610                 1615                 1620             


Ala Lys  Glu Leu Gln Lys Trp  Val Ser Asn Ile Ser  Lys Thr Leu 
    1625                 1630                 1635             


Lys Asp  Ala Glu Lys Ala Gly  Lys Pro Pro Phe Ser  Lys Gln Lys 
    1640                 1645                 1650             


Ile Ser  Ser Glu Glu Ile Ser  Thr Lys Lys Glu Gln  Leu Ser Glu 
    1655                 1660                 1665             


Ala Leu  Gln Thr Ile Gln Leu  Phe Leu Ala Lys His  Gly Asp Lys 
    1670                 1675                 1680             


Met Thr  Asp Glu Glu Arg Asn  Glu Leu Glu Lys Gln  Val Lys Thr 
    1685                 1690                 1695             


Leu Gln  Glu Ser Tyr Asn Leu  Leu Phe Ser Glu Ser  Leu Lys Gln 
    1700                 1705                 1710             


Leu Gln  Glu Ser Gln Thr Ser  Gly Asp Val Lys Val  Glu Glu Lys 
    1715                 1720                 1725             


Ile Val  Ala Glu Arg Gln Gln  Glu Tyr Lys Glu Lys  Leu Gln Gly 
    1730                 1735                 1740             


Ile Cys  Asp Leu Leu Thr Gln  Thr Glu Asn Arg Leu  Ile Gly His 
    1745                 1750                 1755             


Gln Glu  Ala Phe Met Ile Gly  Asp Gly Thr Val Glu  Leu Lys Lys 
    1760                 1765                 1770             


Tyr Gln  Ser Lys Gln Glu Glu  Leu Gln Lys Asp Met  Gln Gly Ser 
    1775                 1780                 1785             


Ala Gln  Ala Leu Ala Glu Val  Val Lys Asn Thr Glu  Asn Phe Leu 
    1790                 1795                 1800             


Lys Glu  Asn Gly Glu Lys Leu  Ser Gln Glu Asp Lys  Ala Leu Ile 
    1805                 1810                 1815             


Glu Gln  Lys Leu Asn Glu Ala  Lys Ile Lys Cys Glu  Gln Leu Asn 
    1820                 1825                 1830             


Leu Lys  Ala Glu Gln Ser Lys  Lys Glu Leu Asp Lys  Val Val Thr 
    1835                 1840                 1845             


Thr Ala  Ile Lys Glu Glu Thr  Glu Lys Val Ala Ala  Val Lys Gln 
    1850                 1855                 1860             


Leu Glu  Glu Ser Lys Thr Lys  Ile Glu Asn Leu Leu  Asp Trp Leu 
    1865                 1870                 1875             


Ser Asn  Val Asp Lys Asp Ser  Glu Arg Ala Gly Thr  Lys His Lys 
    1880                 1885                 1890             


Gln Val  Ile Glu Gln Asn Gly  Thr His Phe Gln Glu  Gly Asp Gly 
    1895                 1900                 1905             


Lys Ser  Ala Ile Gly Glu Glu  Asp Glu Val Asn Gly  Asn Leu Leu 
    1910                 1915                 1920             


Glu Thr  Asp Val Asp Gly Gln  Val Gly Thr Thr Gln  Glu Asn Leu 
    1925                 1930                 1935             


Asn Gln  Gln Tyr Gln Lys Val  Lys Ala Gln His Glu  Lys Ile Ile 
    1940                 1945                 1950             


Ser Gln  His Gln Ala Val Ile  Ile Ala Thr Gln Ser  Ala Gln Val 
    1955                 1960                 1965             


Leu Leu  Glu Lys Gln Gly Gln  Tyr Leu Ser Pro Glu  Glu Lys Glu 
    1970                 1975                 1980             


Lys Leu  Gln Lys Asn Met Lys  Glu Leu Lys Val His  Tyr Glu Thr 
    1985                 1990                 1995             


Ala Leu  Ala Glu Ser Glu Lys  Lys Met Lys Leu Thr  His Ser Leu 
    2000                 2005                 2010             


Gln Glu  Glu Leu Glu Lys Phe  Asp Ala Asp Tyr Thr  Glu Phe Glu 
    2015                 2020                 2025             


His Trp  Leu Gln Gln Ser Glu  Gln Glu Leu Glu Asn  Leu Glu Ala 
    2030                 2035                 2040             


Gly Ala  Asp Asp Ile Asn Gly  Leu Met Thr Lys Leu  Lys Arg Gln 
    2045                 2050                 2055             


Lys Ser  Phe Ser Glu Asp Val  Ile Ser His Lys Gly  Asp Leu Arg 
    2060                 2065                 2070             


Tyr Ile  Thr Ile Ser Gly Asn  Arg Val Leu Glu Ala  Ala Lys Ser 
    2075                 2080                 2085             


Cys Ser  Lys Arg Asp Gly Gly  Lys Val Asp Thr Ser  Ala Thr His 
    2090                 2095                 2100             


Arg Glu  Val Gln Arg Lys Leu  Asp His Ala Thr Asp  Arg Phe Arg 
    2105                 2110                 2115             


Ser Leu  Tyr Ser Lys Cys Asn  Val Leu Gly Asn Asn  Leu Lys Asp 
    2120                 2125                 2130             


Leu Val  Asp Lys Tyr Gln His  Tyr Glu Asp Ala Ser  Cys Gly Leu 
    2135                 2140                 2145             


Leu Ala  Gly Leu Gln Ala Cys  Glu Ala Thr Ala Ser  Lys His Leu 
    2150                 2155                 2160             


Ser Glu  Pro Ile Ala Val Asp  Pro Lys Asn Leu Gln  Arg Gln Leu 
    2165                 2170                 2175             


Glu Glu  Thr Lys Ala Leu Gln  Gly Gln Ile Ser Ser  Gln Gln Val 
    2180                 2185                 2190             


Ala Val  Glu Lys Leu Lys Lys  Thr Ala Glu Val Leu  Leu Asp Ala 
    2195                 2200                 2205             


Arg Gly  Ser Leu Leu Pro Ala  Lys Asn Asp Ile Gln  Lys Thr Leu 
    2210                 2215                 2220             


Asp Asp  Ile Val Gly Arg Tyr  Glu Asp Leu Ser Lys  Ser Val Asn 
    2225                 2230                 2235             


Glu Arg  Asn Glu Lys Leu Gln  Ile Thr Leu Thr Arg  Ser Leu Ser 
    2240                 2245                 2250             


Val Gln  Asp Gly Leu Asp Glu  Met Leu Asp Trp Met  Gly Asn Val 
    2255                 2260                 2265             


Glu Ser  Ser Leu Lys Glu Gln  Gly Gln Val Pro Leu  Asn Ser Thr 
    2270                 2275                 2280             


Ala Leu  Gln Asp Ile Ile Ser  Lys Asn Ile Met Leu  Glu Gln Asp 
    2285                 2290                 2295             


Ile Ala  Gly Arg Gln Ser Ser  Ile Asn Ala Met Asn  Glu Lys Val 
    2300                 2305                 2310             


Lys Lys  Phe Met Glu Thr Thr  Asp Pro Ser Thr Ala  Ser Ser Leu 
    2315                 2320                 2325             


Gln Ala  Lys Met Lys Asp Leu  Ser Ala Arg Phe Ser  Glu Ala Ser 
    2330                 2335                 2340             


His Lys  His Lys Glu Thr Leu  Ala Lys Met Glu Glu  Leu Lys Thr 
    2345                 2350                 2355             


Lys Val  Glu Leu Phe Glu Asn  Leu Ser Glu Lys Leu  Gln Thr Phe 
    2360                 2365                 2370             


Leu Glu  Thr Lys Thr Gln Ala  Leu Thr Glu Val Asp  Val Pro Gly 
    2375                 2380                 2385             


Lys Asp  Val Thr Glu Leu Ser  Gln Tyr Met Gln Glu  Ser Thr Ser 
    2390                 2395                 2400             


Glu Phe  Leu Glu His Lys Lys  His Leu Glu Val Leu  His Ser Leu 
    2405                 2410                 2415             


Leu Lys  Glu Ile Ser Ser His  Gly Leu Pro Ser Asp  Lys Ala Leu 
    2420                 2425                 2430             


Val Leu  Glu Lys Thr Asn Asn  Leu Ser Lys Lys Phe  Lys Glu Met 
    2435                 2440                 2445             


Glu Asp  Thr Ile Lys Glu Lys  Lys Glu Ala Val Thr  Ser Cys Gln 
    2450                 2455                 2460             


Glu Gln  Leu Asp Ala Phe Gln  Val Leu Val Lys Ser  Leu Lys Ser 
    2465                 2470                 2475             


Trp Ile  Lys Glu Thr Thr Lys  Lys Val Pro Ile Val  Gln Pro Ser 
    2480                 2485                 2490             


Phe Gly  Ala Glu Asp Leu Gly  Lys Ser Leu Glu Asp  Thr Lys Lys 
    2495                 2500                 2505             


Leu Gln  Glu Lys Trp Ser Leu  Lys Thr Pro Glu Ile  Gln Lys Val 
    2510                 2515                 2520             


Asn Asn  Ser Gly Ile Ser Leu  Cys Asn Leu Ile Ser  Ala Val Thr 
    2525                 2530                 2535             


Thr Pro  Ala Lys Ala Ile Ala  Ala Val Lys Ser Gly  Gly Ala Val 
    2540                 2545                 2550             


Leu Asn  Gly Glu Gly Thr Ala  Thr Asn Thr Glu Glu  Phe Trp Ala 
    2555                 2560                 2565             


Asn Lys  Gly Leu Thr Ser Ile  Lys Lys Asp Met Thr  Asp Ile Ser 
    2570                 2575                 2580             


His Gly  Tyr Glu Asp Leu Gly  Leu Leu Leu Lys Asp  Lys Ile Ala 
    2585                 2590                 2595             


Glu Leu  Asn Thr Lys Leu Ser  Lys Leu Gln Lys Ala  Gln Glu Glu 
    2600                 2605                 2610             


Ser Ser  Ala Met Met Gln Trp  Leu Gln Lys Met Asn  Lys Thr Ala 
    2615                 2620                 2625             


Thr Lys  Trp Gln Gln Thr Pro  Ala Pro Thr Asp Thr  Glu Ala Val 
    2630                 2635                 2640             


Lys Thr  Gln Val Glu Gln Asn  Lys Ser Phe Glu Ala  Glu Leu Lys 
    2645                 2650                 2655             


Gln Asn  Val Asn Lys Val Gln  Glu Leu Lys Asp Lys  Leu Thr Glu 
    2660                 2665                 2670             


Leu Leu  Glu Glu Asn Pro Asp  Thr Pro Glu Ala Pro  Arg Trp Lys 
    2675                 2680                 2685             


Gln Met  Leu Thr Glu Ile Asp  Ser Lys Trp Gln Glu  Leu Asn Gln 
    2690                 2695                 2700             


Leu Thr  Ile Asp Arg Gln Gln  Lys Leu Glu Glu Ser  Ser Asn Asn 
    2705                 2710                 2715             


Leu Thr  Gln Phe Gln Thr Val  Glu Ala Gln Leu Lys  Gln Trp Leu 
    2720                 2725                 2730             


Val Glu  Lys Glu Leu Met Val  Ser Val Leu Gly Pro  Leu Ser Ile 
    2735                 2740                 2745             


Asp Pro  Asn Met Leu Asn Thr  Gln Arg Gln Gln Val  Gln Ile Leu 
    2750                 2755                 2760             


Leu Gln  Glu Phe Ala Thr Arg  Lys Pro Gln Tyr Glu  Gln Leu Thr 
    2765                 2770                 2775             


Ala Ala  Gly Gln Gly Ile Leu  Ser Arg Pro Gly Glu  Asp Pro Ser 
    2780                 2785                 2790             


Leu Arg  Gly Ile Val Lys Glu  Gln Leu Ala Ala Val  Thr Gln Lys 
    2795                 2800                 2805             


Trp Asp  Ser Leu Thr Gly Gln  Leu Ser Asp Arg Cys  Asp Trp Ile 
    2810                 2815                 2820             


Asp Gln  Ala Ile Val Lys Ser  Thr Gln Tyr Gln Ser  Leu Leu Arg 
    2825                 2830                 2835             


Ser Leu  Ser Asp Lys Leu Ser  Asp Leu Asp Asn Lys  Leu Ser Ser 
    2840                 2845                 2850             


Ser Leu  Ala Val Ser Thr His  Pro Asp Ala Met Asn  Gln Gln Leu 
    2855                 2860                 2865             


Glu Thr  Ala Gln Lys Met Lys  Gln Glu Ile Gln Gln  Glu Lys Lys 
    2870                 2875                 2880             


Gln Ile  Lys Val Ala Gln Ala  Leu Cys Glu Asp Leu  Ser Ala Leu 
    2885                 2890                 2895             


Val Lys  Glu Glu Tyr Leu Lys  Ala Glu Leu Ser Arg  Gln Leu Glu 
    2900                 2905                 2910             


Gly Ile  Leu Lys Ser Phe Lys  Asp Val Glu Gln Lys  Ala Glu Asn 
    2915                 2920                 2925             


His Val  Gln His Leu Gln Ser  Ala Cys Ala Ser Ser  His Gln Phe 
    2930                 2935                 2940             


Gln Gln  Met Ser Arg Asp Phe  Gln Ala Trp Leu Asp  Thr Lys Lys 
    2945                 2950                 2955             


Glu Glu  Gln Asn Lys Ser His  Pro Ile Ser Ala Lys  Leu Asp Val 
    2960                 2965                 2970             


Leu Glu  Ser Leu Ile Lys Asp  His Lys Asp Phe Ser  Lys Thr Leu 
    2975                 2980                 2985             


Thr Ala  Gln Ser His Met Tyr  Glu Lys Thr Ile Ala  Glu Gly Glu 
    2990                 2995                 3000             


Asn Leu  Leu Leu Lys Thr Gln  Gly Ser Glu Lys Ala  Ala Leu Gln 
    3005                 3010                 3015             


Leu Gln  Leu Asn Thr Ile Lys  Thr Asn Trp Asp Thr  Phe Asn Lys 
    3020                 3025                 3030             


Gln Val  Lys Glu Arg Glu Asn  Lys Leu Lys Glu Ser  Leu Glu Lys 
    3035                 3040                 3045             


Ala Leu  Lys Tyr Lys Glu Gln  Val Glu Thr Leu Trp  Pro Trp Ile 
    3050                 3055                 3060             


Asp Lys  Cys Gln Asn Asn Leu  Glu Glu Ile Lys Phe  Cys Leu Asp 
    3065                 3070                 3075             


Pro Ala  Glu Gly Glu Asn Ser  Ile Ala Lys Leu Lys  Ser Leu Gln 
    3080                 3085                 3090             


Lys Glu  Met Asp Gln His Phe  Gly Met Val Glu Leu  Leu Asn Asn 
    3095                 3100                 3105             


Thr Ala  Asn Ser Leu Leu Ser  Val Cys Glu Ile Asp  Lys Glu Val 
    3110                 3115                 3120             


Val Thr  Asp Glu Asn Lys Ser  Leu Ile Gln Lys Val  Asp Met Val 
    3125                 3130                 3135             


Thr Glu  Gln Leu His Ser Lys  Lys Phe Cys Leu Glu  Asn Met Thr 
    3140                 3145                 3150             


Gln Lys  Phe Lys Glu Phe Gln  Glu Val Ser Lys Glu  Ser Lys Arg 
    3155                 3160                 3165             


Gln Leu  Gln Cys Ala Lys Glu  Gln Leu Asp Ile His  Asp Ser Leu 
    3170                 3175                 3180             


Gly Ser  Gln Ala Tyr Ser Asn  Lys Tyr Leu Thr Met  Leu Gln Thr 
    3185                 3190                 3195             


Gln Gln  Lys Ser Leu Gln Ala  Leu Lys His Gln Val  Asp Leu Ala 
    3200                 3205                 3210             


Lys Arg  Leu Ala Gln Asp Leu  Val Val Glu Ala Ser  Asp Ser Lys 
    3215                 3220                 3225             


Gly Thr  Ser Asp Val Leu Leu  Gln Val Glu Thr Ile  Ala Gln Glu 
    3230                 3235                 3240             


His Ser  Thr Leu Ser Gln Gln  Val Asp Glu Lys Cys  Ser Phe Leu 
    3245                 3250                 3255             


Glu Thr  Lys Leu Gln Gly Ile  Gly His Phe Gln Asn  Thr Ile Arg 
    3260                 3265                 3270             


Glu Met  Phe Ser Gln Phe Ala  Glu Phe Asp Asp Glu  Leu Asp Ser 
    3275                 3280                 3285             


Met Ala  Pro Val Gly Arg Asp  Ala Glu Thr Leu Gln  Lys Gln Lys 
    3290                 3295                 3300             


Glu Thr  Ile Lys Ala Phe Leu  Lys Lys Leu Glu Ala  Leu Met Ala 
    3305                 3310                 3315             


Ser Asn  Asp Asn Ala Asn Lys  Thr Cys Lys Met Met  Leu Ala Thr 
    3320                 3325                 3330             


Glu Glu  Thr Ser Pro Asp Leu  Val Gly Ile Lys Arg  Asp Leu Glu 
    3335                 3340                 3345             


Ala Leu  Ser Lys Gln Cys Asn  Lys Leu Leu Asp Arg  Ala Gln Ala 
    3350                 3355                 3360             


Arg Glu  Glu Gln Val Glu Gly  Thr Ile Lys Arg Leu  Glu Glu Phe 
    3365                 3370                 3375             


Tyr Ser  Lys Leu Lys Glu Phe  Ser Ile Leu Leu Gln  Lys Ala Glu 
    3380                 3385                 3390             


Glu His  Glu Glu Ser Gln Gly  Pro Val Gly Met Glu  Thr Glu Thr 
    3395                 3400                 3405             


Ile Asn  Gln Gln Leu Asn Met  Phe Lys Val Phe Gln  Lys Glu Glu 
    3410                 3415                 3420             


Ile Glu  Pro Leu Gln Gly Lys  Gln Gln Asp Val Asn  Trp Leu Gly 
    3425                 3430                 3435             


Gln Gly  Leu Ile Gln Ser Ala  Ala Lys Ser Thr Ser  Thr Gln Gly 
    3440                 3445                 3450             


Leu Glu  His Asp Leu Asp Asp  Val Asn Ala Arg Trp  Lys Thr Leu 
    3455                 3460                 3465             


Asn Lys  Lys Val Ala Gln Arg  Ala Ala Gln Leu Gln  Glu Ala Leu 
    3470                 3475                 3480             


Leu His  Cys Gly Arg Phe Gln  Asp Ala Leu Glu Ser  Leu Leu Ser 
    3485                 3490                 3495             


Trp Met  Val Asp Thr Glu Glu  Leu Val Ala Asn Gln  Lys Pro Pro 
    3500                 3505                 3510             


Ser Ala  Glu Phe Lys Val Val  Lys Ala Gln Ile Gln  Glu Gln Lys 
    3515                 3520                 3525             


Leu Leu  Gln Arg Leu Leu Asp  Asp Arg Lys Ser Thr  Val Glu Val 
    3530                 3535                 3540             


Ile Lys  Arg Glu Gly Glu Lys  Ile Ala Thr Thr Ala  Glu Pro Ala 
    3545                 3550                 3555             


Asp Lys  Val Lys Ile Leu Lys  Gln Leu Ser Leu Leu  Asp Ser Arg 
    3560                 3565                 3570             


Trp Glu  Ala Leu Leu Asn Lys  Ala Glu Thr Arg Asn  Arg Gln Leu 
    3575                 3580                 3585             


Glu Gly  Ile Ser Val Val Ala  Gln Gln Phe His Glu  Thr Leu Glu 
    3590                 3595                 3600             


Pro Leu  Asn Glu Trp Leu Thr  Thr Ile Glu Lys Arg  Leu Val Asn 
    3605                 3610                 3615             


Cys Glu  Pro Ile Gly Thr Gln  Ala Ser Lys Leu Glu  Glu Gln Ile 
    3620                 3625                 3630             


Ala Gln  His Lys Ala Leu Glu  Asp Asp Ile Ile Asn  His Asn Lys 
    3635                 3640                 3645             


His Leu  His Gln Ala Val Ser  Ile Gly Gln Ser Leu  Lys Val Leu 
    3650                 3655                 3660             


Ser Ser  Arg Glu Asp Lys Asp  Met Val Gln Ser Lys  Leu Asp Phe 
    3665                 3670                 3675             


Ser Gln  Val Trp Tyr Ile Glu  Ile Gln Glu Lys Ser  His Ser Arg 
    3680                 3685                 3690             


Ser Glu  Leu Leu Gln Gln Ala  Leu Cys Asn Ala Lys  Ile Phe Gly 
    3695                 3700                 3705             


Glu Asp  Glu Val Glu Leu Met  Asn Trp Leu Asn Glu  Val His Asp 
    3710                 3715                 3720             


Lys Leu  Ser Lys Leu Ser Val  Gln Asp Tyr Ser Thr  Glu Gly Leu 
    3725                 3730                 3735             


Trp Lys  Gln Gln Ser Glu Leu  Arg Val Leu Gln Glu  Asp Ile Leu 
    3740                 3745                 3750             


Leu Arg  Lys Gln Asn Val Asp  Gln Ala Leu Leu Asn  Gly Leu Glu 
    3755                 3760                 3765             


Leu Leu  Lys Gln Thr Thr Gly  Asp Glu Val Leu Ile  Ile Gln Asp 
    3770                 3775                 3780             


Lys Leu  Glu Ala Ile Lys Ala  Arg Tyr Lys Asp Ile  Thr Lys Leu 
    3785                 3790                 3795             


Ser Thr  Asp Val Ala Lys Thr  Leu Glu Gln Ala Leu  Gln Leu Ala 
    3800                 3805                 3810             


Arg Arg  Leu His Ser Thr His  Glu Glu Leu Cys Thr  Trp Leu Asp 
    3815                 3820                 3825             


Lys Val  Glu Val Glu Leu Leu  Ser Tyr Glu Thr Gln  Val Leu Lys 
    3830                 3835                 3840             


Gly Glu  Glu Ala Ser Gln Ala  Gln Met Arg Pro Lys  Glu Leu Lys 
    3845                 3850                 3855             


Lys Glu  Ala Lys Asn Asn Lys  Ala Leu Leu Asp Ser  Leu Asn Glu 
    3860                 3865                 3870             


Val Ser  Ser Ala Leu Leu Glu  Leu Val Pro Trp Arg  Ala Arg Glu 
    3875                 3880                 3885             


Gly Leu  Glu Lys Met Val Ala  Glu Asp Asn Glu Arg  Tyr Arg Leu 
    3890                 3895                 3900             


Val Ser  Asp Thr Ile Thr Gln  Lys Val Glu Glu Ile  Asp Ala Ala 
    3905                 3910                 3915             


Ile Leu  Arg Ser Gln Gln Phe  Asp Gln Ala Ala Asp  Ala Glu Leu 
    3920                 3925                 3930             


Ser Trp  Ile Thr Glu Thr Glu  Lys Lys Leu Met Ser  Leu Gly Asp 
    3935                 3940                 3945             


Ile Arg  Leu Glu Gln Asp Gln  Thr Ser Ala Gln Leu  Gln Val Gln 
    3950                 3955                 3960             


Lys Thr  Phe Thr Met Glu Ile  Leu Arg His Lys Asp  Ile Ile Asp 
    3965                 3970                 3975             


Asp Leu  Val Lys Ser Gly His  Lys Ile Met Thr Ala  Cys Ser Glu 
    3980                 3985                 3990             


Glu Glu  Lys Gln Ser Met Lys  Lys Lys Leu Asp Lys  Val Leu Lys 
    3995                 4000                 4005             


Asn Tyr  Asp Thr Ile Cys Gln  Ile Asn Ser Glu Arg  Tyr Leu Gln 
    4010                 4015                 4020             


Leu Glu  Arg Ala Gln Ser Leu  Val Asn Gln Phe Trp  Glu Thr Tyr 
    4025                 4030                 4035             


Glu Glu  Leu Trp Pro Trp Leu  Thr Glu Thr Gln Ser  Ile Ile Ser 
    4040                 4045                 4050             


Gln Leu  Pro Ala Pro Ala Leu  Glu Tyr Glu Thr Leu  Arg Gln Gln 
    4055                 4060                 4065             


Gln Glu  Glu His Arg Gln Leu  Arg Glu Leu Ile Ala  Glu His Lys 
    4070                 4075                 4080             


Pro His  Ile Asp Lys Met Asn  Lys Thr Gly Pro Gln  Leu Leu Glu 
    4085                 4090                 4095             


Leu Ser  Pro Gly Glu Gly Phe  Ser Ile Gln Glu Lys  Tyr Val Ala 
    4100                 4105                 4110             


Ala Asp  Thr Leu Tyr Ser Gln  Ile Lys Glu Asp Val  Lys Lys Arg 
    4115                 4120                 4125             


Ala Val  Ala Leu Asp Glu Ala  Ile Ser Gln Ser Thr  Gln Phe His 
    4130                 4135                 4140             


Asp Lys  Ile Asp Gln Ile Leu  Glu Ser Leu Glu Arg  Ile Val Glu 
    4145                 4150                 4155             


Arg Leu  Arg Gln Pro Pro Ser  Ile Ser Ala Glu Val  Glu Lys Ile 
    4160                 4165                 4170             


Lys Glu  Gln Ile Ser Glu Asn  Lys Asn Val Ser Val  Asp Met Glu 
    4175                 4180                 4185             


Lys Leu  Gln Pro Leu Tyr Glu  Thr Leu Lys Gln Arg  Gly Glu Glu 
    4190                 4195                 4200             


Met Ile  Ala Arg Ser Gly Gly  Thr Asp Lys Asp Ile  Ser Ala Lys 
    4205                 4210                 4215             


Ala Val  Gln Asp Lys Leu Asp  Gln Met Val Phe Ile  Trp Glu Asn 
    4220                 4225                 4230             


Ile His  Thr Leu Val Glu Glu  Arg Glu Ala Lys Leu  Leu Asp Val 
    4235                 4240                 4245             


Met Glu  Leu Ala Glu Lys Phe  Trp Cys Asp His Met  Ser Leu Ile 
    4250                 4255                 4260             


Val Thr  Ile Lys Asp Thr Gln  Asp Phe Ile Arg Asp  Leu Glu Asp 
    4265                 4270                 4275             


Pro Gly  Ile Asp Pro Ser Val  Val Lys Gln Gln Gln  Glu Ala Ala 
    4280                 4285                 4290             


Glu Thr  Ile Arg Glu Glu Ile  Asp Gly Leu Gln Glu  Glu Leu Asp 
    4295                 4300                 4305             


Ile Val  Ile Asn Leu Gly Ser  Glu Leu Ile Ala Ala  Cys Gly Glu 
    4310                 4315                 4320             


Pro Asp  Lys Pro Ile Val Lys  Lys Ser Ile Asp Glu  Leu Asn Ser 
    4325                 4330                 4335             


Ala Trp  Asp Ser Leu Asn Lys  Ala Trp Lys Asp Arg  Ile Asp Lys 
    4340                 4345                 4350             


Leu Glu  Glu Ala Met Gln Ala  Ala Val Gln Tyr Gln  Asp Gly Leu 
    4355                 4360                 4365             


Gln Ala  Val Phe Asp Trp Val  Asp Ile Ala Gly Gly  Lys Leu Ala 
    4370                 4375                 4380             


Ser Met  Ser Pro Ile Gly Thr  Asp Leu Glu Thr Val  Lys Gln Gln 
    4385                 4390                 4395             


Ile Glu  Glu Leu Lys Gln Phe  Lys Ser Glu Ala Tyr  Gln Gln Gln 
    4400                 4405                 4410             


Ile Glu  Met Glu Arg Leu Asn  His Gln Ala Glu Leu  Leu Leu Lys 
    4415                 4420                 4425             


Lys Val  Thr Glu Glu Ser Asp  Lys His Thr Val Gln  Asp Pro Leu 
    4430                 4435                 4440             


Met Glu  Leu Lys Leu Ile Trp  Asp Ser Leu Glu Glu  Arg Ile Ile 
    4445                 4450                 4455             


Asn Arg  Gln His Lys Leu Glu  Gly Ala Leu Leu Ala  Leu Gly Gln 
    4460                 4465                 4470             


Phe Gln  His Ala Leu Asp Glu  Leu Leu Ala Trp Leu  Thr His Thr 
    4475                 4480                 4485             


Glu Gly  Leu Leu Ser Glu Gln  Lys Pro Val Gly Gly  Asp Pro Lys 
    4490                 4495                 4500             


Ala Ile  Glu Ile Glu Leu Ala  Lys His His Val Leu  Gln Asn Asp 
    4505                 4510                 4515             


Val Leu  Ala His Gln Ser Thr  Val Glu Ala Val Asn  Lys Ala Gly 
    4520                 4525                 4530             


Asn Asp  Leu Ile Glu Ser Ser  Ala Gly Glu Glu Ala  Ser Asn Leu 
    4535                 4540                 4545             


Gln Asn  Lys Leu Glu Val Leu  Asn Gln Arg Trp Gln  Asn Val Leu 
    4550                 4555                 4560             


Glu Lys  Thr Glu Gln Arg Lys  Gln Gln Leu Asp Gly  Ala Leu Arg 
    4565                 4570                 4575             


Gln Ala  Lys Gly Phe His Gly  Glu Ile Glu Asp Leu  Gln Gln Trp 
    4580                 4585                 4590             


Leu Thr  Asp Thr Glu Arg His  Leu Leu Ala Ser Lys  Pro Leu Gly 
    4595                 4600                 4605             


Gly Leu  Pro Glu Thr Ala Lys  Glu Gln Leu Asn Val  His Met Glu 
    4610                 4615                 4620             


Val Cys  Ala Ala Phe Glu Ala  Lys Glu Glu Thr Tyr  Lys Ser Leu 
    4625                 4630                 4635             


Met Gln  Lys Gly Gln Gln Met  Leu Ala Arg Cys Pro  Lys Ser Ala 
    4640                 4645                 4650             


Glu Thr  Asn Ile Asp Gln Asp  Ile Asn Asn Leu Lys  Glu Lys Trp 
    4655                 4660                 4665             


Glu Ser  Val Glu Thr Lys Leu  Asn Glu Arg Lys Thr  Lys Leu Glu 
    4670                 4675                 4680             


Glu Ala  Leu Asn Leu Ala Met  Glu Phe His Asn Ser  Leu Gln Asp 
    4685                 4690                 4695             


Phe Ile  Asn Trp Leu Thr Gln  Ala Glu Gln Thr Leu  Asn Val Ala 
    4700                 4705                 4710             


Ser Arg  Pro Ser Leu Ile Leu  Asp Thr Val Leu Phe  Gln Ile Asp 
    4715                 4720                 4725             


Glu His  Lys Val Phe Ala Asn  Glu Val Asn Ser His  Arg Glu Gln 
    4730                 4735                 4740             


Ile Ile  Glu Leu Asp Lys Thr  Gly Thr His Leu Lys  Tyr Phe Ser 
    4745                 4750                 4755             


Gln Lys  Gln Asp Val Val Leu  Ile Lys Asn Leu Leu  Ile Ser Val 
    4760                 4765                 4770             


Gln Ser  Arg Trp Glu Lys Val  Val Gln Arg Leu Val  Glu Arg Gly 
    4775                 4780                 4785             


Arg Ser  Leu Asp Asp Ala Arg  Lys Arg Ala Lys Gln  Phe His Glu 
    4790                 4795                 4800             


Ala Trp  Ser Lys Leu Met Glu  Trp Leu Glu Glu Ser  Glu Lys Ser 
    4805                 4810                 4815             


Leu Asp  Ser Glu Leu Glu Ile  Ala Asn Asp Pro Asp  Lys Ile Lys 
    4820                 4825                 4830             


Thr Gln  Leu Ala Gln His Lys  Glu Phe Gln Lys Ser  Leu Gly Ala 
    4835                 4840                 4845             


Lys His  Ser Val Tyr Asp Thr  Thr Asn Arg Thr Gly  Arg Ser Leu 
    4850                 4855                 4860             


Lys Glu  Lys Thr Ser Leu Ala  Asp Asp Asn Leu Lys  Leu Asp Asp 
    4865                 4870                 4875             


Met Leu  Ser Glu Leu Arg Asp  Lys Trp Asp Thr Ile  Cys Gly Lys 
    4880                 4885                 4890             


Ser Val  Glu Arg Gln Asn Lys  Leu Glu Glu Ala Leu  Leu Phe Ser 
    4895                 4900                 4905             


Gly Gln  Phe Thr Asp Ala Leu  Gln Ala Leu Ile Asp  Trp Leu Tyr 
    4910                 4915                 4920             


Arg Val  Glu Pro Gln Leu Ala  Glu Asp Gln Pro Val  His Gly Asp 
    4925                 4930                 4935             


Ile Asp  Leu Val Met Asn Leu  Ile Asp Asn His Lys  Ala Phe Gln 
    4940                 4945                 4950             


Lys Glu  Leu Gly Lys Arg Thr  Ser Ser Val Gln Ala  Leu Lys Arg 
    4955                 4960                 4965             


Ser Ala  Arg Glu Leu Ile Glu  Gly Ser Arg Asp Asp  Ser Ser Trp 
    4970                 4975                 4980             


Val Lys  Val Gln Met Gln Glu  Leu Ser Thr Arg Trp  Glu Thr Val 
    4985                 4990                 4995             


Cys Ala  Leu Ser Ile Ser Lys  Gln Thr Arg Leu Glu  Ala Ala Leu 
    5000                 5005                 5010             


Arg Gln  Ala Glu Glu Phe His  Ser Val Val His Ala  Leu Leu Glu 
    5015                 5020                 5025             


Trp Leu  Ala Glu Ala Glu Gln  Thr Leu Arg Phe His  Gly Val Leu 
    5030                 5035                 5040             


Pro Asp  Asp Glu Asp Ala Leu  Arg Thr Leu Ile Asp  Gln His Lys 
    5045                 5050                 5055             


Glu Phe  Met Lys Lys Leu Glu  Glu Lys Arg Ala Glu  Leu Asn Lys 
    5060                 5065                 5070             


Ala Thr  Thr Met Gly Asp Thr  Val Leu Ala Ile Cys  His Pro Asp 
    5075                 5080                 5085             


Ser Ile  Thr Thr Ile Lys His  Trp Ile Thr Ile Ile  Arg Ala Arg 
    5090                 5095                 5100             


Phe Glu  Glu Val Leu Ala Trp  Ala Lys Gln His Gln  Gln Arg Leu 
    5105                 5110                 5115             


Ala Ser  Ala Leu Ala Gly Leu  Ile Ala Lys Gln Glu  Leu Leu Glu 
    5120                 5125                 5130             


Ala Leu  Leu Ala Trp Leu Gln  Trp Ala Glu Thr Thr  Leu Thr Asp 
    5135                 5140                 5145             


Lys Asp  Lys Glu Val Ile Pro  Gln Glu Ile Glu Glu  Val Lys Ala 
    5150                 5155                 5160             


Leu Ile  Ala Glu His Gln Thr  Phe Met Glu Glu Met  Thr Arg Lys 
    5165                 5170                 5175             


Gln Pro  Asp Val Asp Lys Val  Thr Lys Thr Tyr Lys  Arg Arg Ala 
    5180                 5185                 5190             


Ala Asp  Pro Ser Ser Leu Gln  Ser His Ile Pro Val  Leu Asp Lys 
    5195                 5200                 5205             


Gly Arg  Ala Gly Arg Lys Arg  Phe Pro Ala Ser Ser  Leu Tyr Pro 
    5210                 5215                 5220             


Ser Gly  Ser Gln Thr Gln Ile  Glu Thr Lys Asn Pro  Arg Val Asn 
    5225                 5230                 5235             


Leu Leu  Val Ser Lys Trp Gln  Gln Val Trp Leu Leu  Ala Leu Glu 
    5240                 5245                 5250             


Arg Arg  Arg Lys Leu Asn Asp  Ala Leu Asp Arg Leu  Glu Glu Leu 
    5255                 5260                 5265             


Arg Glu  Phe Ala Asn Phe Asp  Phe Asp Ile Trp Arg  Lys Lys Tyr 
    5270                 5275                 5280             


Met Arg  Trp Met Asn His Lys  Lys Ser Arg Val Met  Asp Phe Phe 
    5285                 5290                 5295             


Arg Arg  Ile Asp Lys Asp Gln  Asp Gly Lys Ile Thr  Arg Gln Glu 
    5300                 5305                 5310             


Phe Ile  Asp Gly Ile Leu Ser  Ser Lys Phe Pro Thr  Ser Arg Leu 
    5315                 5320                 5325             


Glu Met  Ser Ala Val Ala Asp  Ile Phe Asp Arg Asp  Gly Asp Gly 
    5330                 5335                 5340             


Tyr Ile  Asp Tyr Tyr Glu Phe  Val Ala Ala Leu His  Pro Asn Lys 
    5345                 5350                 5355             


Asp Ala  Tyr Lys Pro Ile Thr  Asp Ala Asp Lys Ile  Glu Asp Glu 
    5360                 5365                 5370             


Val Thr  Arg Gln Val Ala Lys  Cys Lys Cys Ala Lys  Arg Phe Gln 
    5375                 5380                 5385             


Val Glu  Gln Ile Gly Asp Asn  Lys Tyr Arg Phe Phe  Leu Gly Asn 
    5390                 5395                 5400             


Gln Phe  Gly Asp Ser Gln Gln  Leu Arg Leu Val Arg  Ile Leu Arg 
    5405                 5410                 5415             


Ser Thr  Val Met Val Arg Val  Gly Gly Gly Trp Met  Ala Leu Asp 
    5420                 5425                 5430             


Glu Phe  Leu Val Lys Asn Asp  Pro Cys Arg Ala Lys  Gly Arg Thr 
    5435                 5440                 5445             


Asn Met  Glu Leu Arg Glu Lys  Phe Ile Leu Ala Asp  Gly Ala Ser 
    5450                 5455                 5460             


Gln Gly  Met Ala Ala Phe Arg  Pro Arg Gly Arg Arg  Ser Arg Pro 
    5465                 5470                 5475             


Ser Ser  Arg Gly Ala Ser Pro  Asn Arg Ser Thr Ser  Val Ser Ser 
    5480                 5485                 5490             


Gln Ala  Ala Gln Ala Ala Ser  Pro Gln Val Pro Ala  Thr Thr Thr 
    5495                 5500                 5505             


Pro Lys  Ile Leu His Pro Leu  Thr Arg Asn Tyr Gly  Lys Pro Trp 
    5510                 5515                 5520             


Leu Thr  Asn Ser Lys Met Ser  Thr Pro Cys Lys Ala  Ala Glu Cys 
    5525                 5530                 5535             


Ser Asp  Phe Pro Val Pro Ser  Ala Glu Gly Thr Pro  Ile Gln Gly 
    5540                 5545                 5550             


Ser Lys  Leu Arg Leu Pro Gly  Tyr Leu Ser Gly Lys  Gly Phe His 
    5555                 5560                 5565             


Ser Gly  Glu Asp Ser Gly Leu  Ile Thr Thr Ala Ala  Ala Arg Val 
    5570                 5575                 5580             


Arg Thr  Gln Phe Ala Asp Ser  Lys Lys Thr Pro Ser  Arg Pro Gly 
    5585                 5590                 5595             


Ser Arg  Ala Gly Ser Lys Ala  Gly Ser Arg Ala Ser  Ser Arg Arg 
    5600                 5605                 5610             


Gly Ser  Asp Ala Ser Asp Phe  Asp Ile Ser Glu Ile  Gln Ser Val 
    5615                 5620                 5625             


Cys Ser  Asp Val Glu Thr Val  Pro Gln Thr His Arg  Pro Thr Pro 
    5630                 5635                 5640             


Arg Ala  Gly Ser Arg Pro Ser  Thr Ala Lys Pro Ser  Lys Ile Pro 
    5645                 5650                 5655             


Thr Pro  Gln Arg Lys Ser Pro  Ala Ser Lys Leu Asp  Lys Ser Ser 
    5660                 5665                 5670             


Lys Arg  
    5675 


<210>  1775
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  1775

Met Thr Lys Lys Arg Ile Ala Val Ile Gly Gly Gly Val Ser Gly Leu 
1               5                   10                  15      


Ser Ser Ile Lys Cys Cys Val Glu Glu Gly Leu Glu Pro Val Cys Phe 
            20                  25                  30          


Glu Arg Thr Asp Asp Ile Gly Gly Leu Trp Arg Phe Gln Glu Asn Pro 
        35                  40                  45              


Glu Glu Gly Arg Ala Ser Ile Tyr Lys Ser Val Ile Ile Asn Thr Ser 
    50                  55                  60                  


Lys Glu Met Met Cys Phe Ser Asp Tyr Pro Ile Pro Asp His Tyr Pro 
65                  70                  75                  80  


Asn Phe Met His Asn Ala Gln Val Leu Glu Tyr Phe Arg Met Tyr Ala 
                85                  90                  95      


Lys Glu Phe Asp Leu Leu Lys Tyr Ile Arg Phe Lys Thr Thr Val Cys 
            100                 105                 110         


Ser Val Lys Lys Gln Pro Asp Phe Ala Thr Ser Gly Gln Trp Glu Val 
        115                 120                 125             


Val Thr Glu Ser Glu Gly Lys Lys Glu Met Asn Val Phe Asp Gly Val 
    130                 135                 140                 


Met Val Cys Thr Gly His His Thr Asn Ala His Leu Pro Leu Glu Ser 
145                 150                 155                 160 


Phe Pro Gly Ile Glu Lys Phe Lys Gly Gln Tyr Phe His Ser Arg Asp 
                165                 170                 175     


Tyr Lys Asn Pro Glu Gly Phe Thr Gly Lys Arg Val Ile Ile Ile Gly 
            180                 185                 190         


Ile Gly Asn Ser Gly Gly Asp Leu Ala Val Glu Ile Ser Gln Thr Ala 
        195                 200                 205             


Lys Gln Val Phe Leu Ser Thr Arg Arg Gly Ala Trp Ile Leu Asn Arg 
    210                 215                 220                 


Val Gly Asp Tyr Gly Tyr Pro Ala Asp Val Leu Phe Ser Ser Arg Leu 
225                 230                 235                 240 


Thr His Phe Ile Trp Lys Ile Cys Gly Gln Ser Leu Ala Asn Lys Tyr 
                245                 250                 255     


Leu Glu Lys Lys Ile Asn Gln Arg Phe Asp His Glu Met Phe Gly Leu 
            260                 265                 270         


Lys Pro Lys His Arg Ala Leu Ser Gln His Pro Thr Leu Asn Asp Asp 
        275                 280                 285             


Leu Pro Asn Arg Ile Ile Ser Gly Leu Val Lys Val Lys Gly Asn Val 
    290                 295                 300                 


Lys Glu Phe Thr Glu Thr Ala Ala Ile Phe Glu Asp Gly Ser Arg Glu 
305                 310                 315                 320 


Asp Asp Ile Asp Ala Val Ile Phe Ala Thr Gly Tyr Ser Phe Asp Phe 
                325                 330                 335     


Pro Phe Leu Glu Asp Ser Val Lys Val Val Lys Asn Lys Ile Ser Leu 
            340                 345                 350         


Tyr Lys Lys Val Phe Pro Pro Asn Leu Glu Arg Pro Thr Leu Ala Ile 
        355                 360                 365             


Ile Gly Leu Ile Gln Pro Leu Gly Ala Ile Met Pro Ile Ser Glu Leu 
    370                 375                 380                 


Gln Gly Arg Trp Ala Thr Gln Val Phe Lys Gly Leu Lys Thr Leu Pro 
385                 390                 395                 400 


Ser Gln Ser Glu Met Met Ala Glu Ile Ser Lys Ala Gln Glu Glu Ile 
                405                 410                 415     


Asp Lys Ser Leu Thr Met Arg Lys Thr Ser Asp Lys Pro Lys Leu Lys 
            420                 425                 430         


Asn Ile Leu Gln Ile Pro Asp Tyr Leu Lys Thr Val Lys Ile Ile Asn 
        435                 440                 445             


Lys Glu Ser Leu Arg Asn Cys Pro Gly Ile Lys Gly Pro Lys Glu Thr 
    450                 455                 460                 


<210>  1776
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  1776

Met Thr Lys Lys Arg Ile Ala Val Ile Gly Gly Gly Val Ser Gly Leu 
1               5                   10                  15      


Ser Ser Ile Lys Cys Cys Val Glu Glu Gly Leu Glu Pro Val Cys Phe 
            20                  25                  30          


Glu Arg Thr Asp Asp Ile Gly Gly Leu Trp Arg Phe Gln Glu Asn Pro 
        35                  40                  45              


Glu Glu Gly Arg Ala Ser Ile Tyr Lys Ser Val Ile Ile Asn Thr Ser 
    50                  55                  60                  


Lys Glu Met Met Cys Phe Ser Asp Tyr Pro Ile Pro Asp His Tyr Pro 
65                  70                  75                  80  


Asn Phe Met His Asn Ala Gln Val Leu Glu Tyr Phe Arg Met Tyr Ala 
                85                  90                  95      


Lys Glu Phe Asp Leu Leu Lys Tyr Ile Arg Phe Lys Thr Thr Val Cys 
            100                 105                 110         


Ser Val Lys Lys Gln Pro Asp Phe Ala Thr Ser Gly Gln Trp Glu Val 
        115                 120                 125             


Val Thr Glu Ser Glu Gly Lys Lys Glu Met Asn Val Phe Asp Gly Val 
    130                 135                 140                 


Met Val Cys Thr Gly His His Thr Asn Ala His Leu Pro Leu Glu Ser 
145                 150                 155                 160 


Phe Pro Gly Ile Glu Lys Phe Lys Gly Gln Tyr Phe His Ser Arg Asp 
                165                 170                 175     


Tyr Lys Asn Pro Glu Gly Phe Thr Gly Lys Arg Val Ile Ile Ile Gly 
            180                 185                 190         


Ile Gly Asn Ser Gly Gly Asp Leu Ala Val Glu Ile Ser Gln Thr Ala 
        195                 200                 205             


Lys Gln Val Phe Leu Ser Thr Arg Arg Gly Ala Trp Ile Leu Asn Arg 
    210                 215                 220                 


Val Gly Asp Tyr Gly Tyr Pro Ala Asp Val Leu Phe Ser Ser Arg Leu 
225                 230                 235                 240 


Thr His Phe Ile Trp Lys Ile Cys Gly Gln Ser Leu Ala Asn Lys Tyr 
                245                 250                 255     


Leu Glu Lys Lys Ile Asn Gln Arg Phe Asp His Glu Met Phe Gly Leu 
            260                 265                 270         


Lys Pro Lys His Arg Ser Lys Asp Ile Ala Leu Thr Glu 
        275                 280                 285 


<210>  1777
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  1777

Met Ser Gly Glu Ser Met Asn Phe Ser Asp Val Phe Asp Ser Ser Glu 
1               5                   10                  15      


Asp Tyr Phe Val Ser Val Asn Thr Ser Tyr Tyr Ser Val Asp Ser Glu 
            20                  25                  30          


Met Leu Leu Cys Ser Leu Gln Glu Val Arg Gln Phe Ser Arg Leu Phe 
        35                  40                  45              


Val Pro Ile Ala Tyr Ser Leu Ile Cys Val Phe Gly Leu Leu Gly Asn 
    50                  55                  60                  


Ile Leu Val Val Ile Thr Phe Ala Phe Tyr Lys Lys Ala Arg Ser Met 
65                  70                  75                  80  


Thr Asp Val Tyr Leu Leu Asn Met Ala Ile Ala Asp Ile Leu Phe Val 
                85                  90                  95      


Leu Thr Leu Pro Phe Trp Ala Val Ser His Ala Thr Gly Ala Trp Val 
            100                 105                 110         


Phe Ser Asn Ala Thr Cys Lys Leu Leu Lys Gly Ile Tyr Ala Ile Asn 
        115                 120                 125             


Phe Asn Cys Gly Met Leu Leu Leu Thr Cys Ile Ser Met Asp Arg Tyr 
    130                 135                 140                 


Ile Ala Ile Val Gln Ala Thr Lys Ser Phe Arg Leu Arg Ser Arg Thr 
145                 150                 155                 160 


Leu Pro Arg Ser Lys Ile Ile Cys Leu Val Val Trp Gly Leu Ser Val 
                165                 170                 175     


Ile Ile Ser Ser Ser Thr Phe Val Phe Asn Gln Lys Tyr Asn Thr Gln 
            180                 185                 190         


Gly Ser Asp Val Cys Glu Pro Lys Tyr Gln Thr Val Ser Glu Pro Ile 
        195                 200                 205             


Arg Trp Lys Leu Leu Met Leu Gly Leu Glu Leu Leu Phe Gly Phe Phe 
    210                 215                 220                 


Ile Pro Leu Met Phe Met Ile Phe Cys Tyr Thr Phe Ile Val Lys Thr 
225                 230                 235                 240 


Leu Val Gln Ala Gln Asn Ser Lys Arg His Lys Ala Ile Arg Val Ile 
                245                 250                 255     


Ile Ala Val Val Leu Val Phe Leu Ala Cys Gln Ile Pro His Asn Met 
            260                 265                 270         


Val Leu Leu Val Thr Ala Ala Asn Leu Gly Lys Met Asn Arg Ser Cys 
        275                 280                 285             


Gln Ser Glu Lys Leu Ile Gly Tyr Thr Lys Thr Val Thr Glu Val Leu 
    290                 295                 300                 


Ala Phe Leu His Cys Cys Leu Asn Pro Val Leu Tyr Ala Phe Ile Gly 
305                 310                 315                 320 


Gln Lys Phe Arg Asn Tyr Phe Leu Lys Ile Leu Lys Asp Leu Trp Cys 
                325                 330                 335     


Val Arg Arg Lys Tyr Lys Ser Ser Gly Phe Ser Cys Ala Gly Arg Tyr 
            340                 345                 350         


Ser Glu Asn Ile Ser Arg Gln Thr Ser Glu Thr Ala Asp Asn Asp Asn 
        355                 360                 365             


Ala Ser Ser Phe Thr Met 
    370                 


<210>  1778
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  1778

Met Ser Gly Glu Ser Met Asn Phe Ser Asp Val Phe Asp Ser Ser Glu 
1               5                   10                  15      


Asp Tyr Phe Val Ser Val Asn Thr Ser Tyr Tyr Ser Val Asp Ser Glu 
            20                  25                  30          


Met Leu Leu Cys Ser Leu Gln Glu Val Arg Gln Phe Ser Arg Leu Phe 
        35                  40                  45              


Val Pro Ile Ala Tyr Ser Leu Ile Cys Val Phe Gly Leu Leu Gly Asn 
    50                  55                  60                  


Ile Leu Val Val Ile Thr Phe Ala Phe Tyr Lys Lys Ala Arg Ser Met 
65                  70                  75                  80  


Thr Asp Val Tyr Leu Leu Asn Met Ala Ile Ala Asp Ile Leu Phe Val 
                85                  90                  95      


Leu Thr Leu Pro Phe Trp Ala Val Ser His Ala Thr Gly Ala Trp Val 
            100                 105                 110         


Phe Ser Asn Ala Thr Cys Lys Leu Leu Lys Gly Ile Tyr Ala Ile Asn 
        115                 120                 125             


Phe Asn Cys Gly Met Leu Leu Leu Thr Cys Ile Ser Met Asp Arg Tyr 
    130                 135                 140                 


Ile Ala Ile Val Gln Ala Thr Lys Ser Phe Arg Leu Arg Ser Arg Thr 
145                 150                 155                 160 


Leu Pro Arg Ser Lys Ile Ile Cys Leu Val Val Trp Gly Leu Ser Val 
                165                 170                 175     


Ile Ile Ser Ser Ser Thr Phe Val Phe Asn Gln Lys Tyr Asn Thr Gln 
            180                 185                 190         


Gly Ser Asp Val Cys Glu Pro Lys Tyr Gln Thr Val Ser Glu Pro Ile 
        195                 200                 205             


Arg Trp Lys Leu Leu Met Leu Gly Leu Glu Leu Leu Phe Gly Phe Phe 
    210                 215                 220                 


Ile Pro Leu Met Phe Met Ile Phe Cys Tyr Thr Phe Ile Val Lys Thr 
225                 230                 235                 240 


Leu Val Gln Ala Gln Asn Ser Lys Arg His Lys Ala Ile Arg Val Ile 
                245                 250                 255     


Ile Ala Val Val Leu Val Phe Leu Ala Cys Gln Ile Pro His Asn Met 
            260                 265                 270         


Val Leu Leu Val Thr Ala Ala Asn Leu Gly Lys Met Asn Arg Ser Cys 
        275                 280                 285             


Gln Ser Glu Lys Leu Ile Gly Tyr Thr Lys Thr Val Thr Glu Val Leu 
    290                 295                 300                 


Ala Phe Leu His Cys Cys Leu Asn Pro Val Leu Tyr Ala Phe Ile Gly 
305                 310                 315                 320 


Gln Lys Phe Arg Asn Tyr Phe Leu Lys Ile Leu Lys Asp Leu Trp Cys 
                325                 330                 335     


Val Arg Arg Lys Tyr Lys Ser Ser Gly Phe Ser Cys Ala Gly Arg Tyr 
            340                 345                 350         


Ser Glu Asn Ile Ser Arg Gln Thr Ser Glu Thr Ala Asp Asn Asp Asn 
        355                 360                 365             


Ala Ser Ser Phe Thr Met 
    370                 


<210>  1779
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  1779

Met Leu Pro Leu Ser Ile Lys Asp Asp Glu Tyr Lys Pro Pro Lys Phe 
1               5                   10                  15      


Asn Leu Phe Gly Lys Ile Ser Gly Trp Phe Arg Ser Ile Leu Ser Asp 
            20                  25                  30          


Lys Thr Ser Arg Asn Leu Phe Phe Phe Leu Cys Leu Asn Leu Ser Phe 
        35                  40                  45              


Ala Phe Val Glu Leu Leu Tyr Gly Ile Trp Ser Asn Cys Leu Gly Leu 
    50                  55                  60                  


Ile Ser Asp Ser Phe His Met Phe Phe Asp Ser Thr Ala Ile Leu Ala 
65                  70                  75                  80  


Gly Leu Ala Ala Ser Val Ile Ser Lys Trp Arg Asp Asn Asp Ala Phe 
                85                  90                  95      


Ser Tyr Gly Tyr Val Arg Ala Glu Val Leu Ala Gly Phe Val Asn Gly 
            100                 105                 110         


Leu Phe Leu Ile Phe Thr Ala Phe Phe Ile Phe Ser Glu Gly Val Glu 
        115                 120                 125             


Arg Ala Leu Ala Pro Pro Asp Val His His Glu Arg Leu Leu Leu Val 
    130                 135                 140                 


Ser Ile Leu Gly Phe Val Val Asn Leu Ile Gly Ile Phe Val Phe Lys 
145                 150                 155                 160 


His Gly Gly His Gly His Ser His Gly Ser Gly His Gly His Ser His 
                165                 170                 175     


Ser Leu Phe Asn Gly Ala Leu Asp Gln Ala His Gly His Val Asp His 
            180                 185                 190         


Cys His Ser His Glu Val Lys His Gly Ala Ala His Ser His Asp His 
        195                 200                 205             


Ala His Gly His Gly His Phe His Ser His Asp Gly Pro Ser Leu Lys 
    210                 215                 220                 


Glu Thr Thr Gly Pro Ser Arg Gln Ile Leu Gln Gly Val Phe Leu His 
225                 230                 235                 240 


Ile Leu Ala Asp Thr Leu Gly Ser Ile Gly Val Ile Ala Ser Ala Ile 
                245                 250                 255     


Met Met Gln Asn Phe Gly Leu Met Ile Ala Asp Pro Ile Cys Ser Ile 
            260                 265                 270         


Leu Ile Ala Ile Leu Ile Val Val Ser Val Ile Pro Leu Leu Arg Glu 
        275                 280                 285             


Ser Val Gly Ile Leu Met Gln Arg Thr Pro Pro Leu Leu Glu Asn Ser 
    290                 295                 300                 


Leu Pro Gln Cys Tyr Gln Arg Val Gln Gln Leu Gln Gly Val Tyr Ser 
305                 310                 315                 320 


Leu Gln Glu Gln His Phe Trp Thr Leu Cys Ser Asp Val Tyr Val Gly 
                325                 330                 335     


Thr Leu Lys Leu Ile Val Ala Pro Asp Ala Asp Ala Arg Trp Ile Leu 
            340                 345                 350         


Ser Gln Thr His Asn Ile Phe Thr Gln Ala Gly Val Arg Gln Leu Tyr 
        355                 360                 365             


Val Gln Ile Asp Phe Ala Ala Met 
    370                 375     


<210>  1780
<211>  610
<212>  PRT
<213>  Homo sapiens

<400>  1780

Met Ser Arg Ser Pro Leu Asn Pro Ser Gln Leu Arg Ser Val Gly Ser 
1               5                   10                  15      


Gln Asp Ala Leu Ala Pro Leu Pro Pro Pro Ala Pro Gln Asn Pro Ser 
            20                  25                  30          


Thr His Ser Trp Asp Pro Leu Cys Gly Ser Leu Pro Trp Gly Leu Ser 
        35                  40                  45              


Cys Leu Leu Ala Leu Gln His Val Leu Val Met Ala Ser Leu Leu Cys 
    50                  55                  60                  


Val Ser His Leu Leu Leu Leu Cys Ser Leu Ser Pro Gly Gly Leu Ser 
65                  70                  75                  80  


Tyr Ser Pro Ser Gln Leu Leu Ala Ser Ser Phe Phe Ser Cys Gly Met 
                85                  90                  95      


Ser Thr Ile Leu Gln Thr Trp Met Gly Ser Arg Leu Pro Leu Val Gln 
            100                 105                 110         


Ala Pro Ser Leu Glu Phe Leu Ile Pro Ala Leu Val Leu Thr Ser Gln 
        115                 120                 125             


Lys Leu Pro Arg Ala Ile Gln Thr Pro Gly Asn Ser Ser Leu Met Leu 
    130                 135                 140                 


His Leu Cys Arg Gly Pro Ser Cys His Gly Leu Gly His Trp Asn Thr 
145                 150                 155                 160 


Ser Leu Gln Glu Val Ser Gly Ala Val Val Val Ser Gly Leu Leu Gln 
                165                 170                 175     


Gly Met Met Gly Leu Leu Gly Ser Pro Gly His Val Phe Pro His Cys 
            180                 185                 190         


Gly Pro Leu Val Leu Ala Pro Ser Leu Val Val Ala Gly Leu Ser Ala 
        195                 200                 205             


His Arg Glu Val Ala Gln Phe Cys Phe Thr His Trp Gly Leu Ala Leu 
    210                 215                 220                 


Leu Val Ile Leu Leu Met Val Val Cys Ser Gln His Leu Gly Ser Cys 
225                 230                 235                 240 


Gln Phe His Val Cys Pro Trp Arg Arg Ala Ser Thr Ser Ser Thr His 
                245                 250                 255     


Thr Pro Leu Pro Val Phe Arg Leu Leu Ser Val Leu Ile Pro Val Ala 
            260                 265                 270         


Cys Val Trp Ile Val Ser Ala Phe Val Gly Phe Ser Val Ile Pro Gln 
        275                 280                 285             


Glu Leu Ser Ala Pro Thr Lys Ala Pro Trp Ile Trp Leu Pro His Pro 
    290                 295                 300                 


Gly Glu Trp Asn Trp Pro Leu Leu Thr Pro Arg Ala Leu Ala Ala Gly 
305                 310                 315                 320 


Ile Ser Met Ala Leu Ala Ala Ser Thr Ser Ser Leu Gly Cys Tyr Ala 
                325                 330                 335     


Leu Cys Gly Arg Leu Leu His Leu Pro Pro Pro Pro Pro His Ala Cys 
            340                 345                 350         


Ser Arg Gly Leu Ser Leu Glu Gly Leu Gly Ser Val Leu Ala Gly Leu 
        355                 360                 365             


Leu Gly Ser Pro Met Gly Thr Ala Ser Ser Phe Pro Asn Val Gly Lys 
    370                 375                 380                 


Val Gly Leu Ile Gln Ala Gly Ser Gln Gln Val Ala His Leu Val Gly 
385                 390                 395                 400 


Leu Leu Cys Val Gly Leu Gly Leu Ser Pro Arg Leu Ala Gln Leu Leu 
                405                 410                 415     


Thr Thr Ile Pro Leu Pro Val Val Gly Gly Val Leu Gly Val Thr Gln 
            420                 425                 430         


Ala Val Val Leu Ser Ala Gly Phe Ser Ser Phe Tyr Leu Ala Asp Ile 
        435                 440                 445             


Asp Ser Gly Arg Asn Ile Phe Ile Val Gly Phe Ser Ile Phe Met Ala 
    450                 455                 460                 


Leu Leu Leu Pro Arg Trp Phe Arg Glu Ala Pro Val Leu Phe Ser Thr 
465                 470                 475                 480 


Gly Trp Ser Pro Leu Asp Val Leu Leu His Ser Leu Leu Thr Gln Pro 
                485                 490                 495     


Ile Phe Leu Ala Gly Leu Ser Gly Phe Leu Leu Glu Asn Thr Ile Pro 
            500                 505                 510         


Gly Thr Gln Leu Glu Arg Gly Leu Gly Gln Gly Leu Pro Ser Pro Phe 
        515                 520                 525             


Thr Ala Gln Glu Ala Arg Met Pro Gln Lys Pro Arg Glu Lys Ala Ala 
    530                 535                 540                 


Gln Val Tyr Arg Leu Pro Phe Pro Ile Gln Asn Leu Cys Pro Cys Ile 
545                 550                 555                 560 


Pro Gln Pro Leu His Cys Leu Cys Pro Leu Pro Glu Asp Pro Gly Asp 
                565                 570                 575     


Glu Glu Gly Gly Ser Ser Glu Pro Glu Glu Met Ala Asp Leu Leu Pro 
            580                 585                 590         


Gly Ser Gly Glu Pro Cys Pro Glu Ser Ser Arg Glu Gly Phe Arg Ser 
        595                 600                 605             


Gln Lys 
    610 


<210>  1781
<211>  618
<212>  PRT
<213>  Homo sapiens

<400>  1781

Met Ser Arg Ser Pro Leu Asn Pro Ser Gln Leu Arg Ser Val Gly Ser 
1               5                   10                  15      


Gln Asp Ala Leu Ala Pro Leu Pro Pro Pro Ala Pro Gln Asn Pro Ser 
            20                  25                  30          


Thr His Ser Trp Asp Pro Leu Cys Gly Ser Leu Pro Trp Gly Leu Ser 
        35                  40                  45              


Cys Leu Leu Ala Leu Gln His Val Leu Val Met Ala Ser Leu Leu Cys 
    50                  55                  60                  


Val Ser His Leu Leu Leu Leu Cys Ser Leu Ser Pro Gly Gly Leu Ser 
65                  70                  75                  80  


Tyr Ser Pro Ser Gln Leu Leu Ala Ser Ser Phe Phe Ser Cys Gly Met 
                85                  90                  95      


Ser Thr Ile Leu Gln Thr Trp Met Gly Ser Arg Leu Pro Leu Val Gln 
            100                 105                 110         


Ala Pro Ser Leu Glu Phe Leu Ile Pro Ala Leu Val Leu Thr Ser Gln 
        115                 120                 125             


Lys Leu Pro Arg Ala Ile Gln Thr Pro Gly Asn Cys Glu His Arg Ala 
    130                 135                 140                 


Arg Ala Arg Ala Ser Leu Met Leu His Leu Cys Arg Gly Pro Ser Cys 
145                 150                 155                 160 


His Gly Leu Gly His Trp Asn Thr Ser Leu Gln Glu Val Ser Gly Ala 
                165                 170                 175     


Val Val Val Ser Gly Leu Leu Gln Gly Met Met Gly Leu Leu Gly Ser 
            180                 185                 190         


Pro Gly His Val Phe Pro His Cys Gly Pro Leu Val Leu Ala Pro Ser 
        195                 200                 205             


Leu Val Val Ala Gly Leu Ser Ala His Arg Glu Val Ala Gln Phe Cys 
    210                 215                 220                 


Phe Thr His Trp Gly Leu Ala Leu Leu Val Ile Leu Leu Met Val Val 
225                 230                 235                 240 


Cys Ser Gln His Leu Gly Ser Cys Gln Phe His Val Cys Pro Trp Arg 
                245                 250                 255     


Arg Ala Ser Thr Ser Ser Thr His Thr Pro Leu Pro Val Phe Arg Leu 
            260                 265                 270         


Leu Ser Val Leu Ile Pro Val Ala Cys Val Trp Ile Val Ser Ala Phe 
        275                 280                 285             


Val Gly Phe Ser Val Ile Pro Gln Glu Leu Ser Ala Pro Thr Lys Ala 
    290                 295                 300                 


Pro Trp Ile Trp Leu Pro His Pro Gly Glu Trp Asn Trp Pro Leu Leu 
305                 310                 315                 320 


Thr Pro Arg Ala Leu Ala Ala Gly Ile Ser Met Ala Leu Ala Ala Ser 
                325                 330                 335     


Thr Ser Ser Leu Gly Cys Tyr Ala Leu Cys Gly Arg Leu Leu His Leu 
            340                 345                 350         


Pro Pro Pro Pro Pro His Ala Cys Ser Arg Gly Leu Ser Leu Glu Gly 
        355                 360                 365             


Leu Gly Ser Val Leu Ala Gly Leu Leu Gly Ser Pro Met Gly Thr Ala 
    370                 375                 380                 


Ser Ser Phe Pro Asn Val Gly Lys Val Gly Leu Ile Gln Ala Gly Ser 
385                 390                 395                 400 


Gln Gln Val Ala His Leu Val Gly Leu Leu Cys Val Gly Leu Gly Leu 
                405                 410                 415     


Ser Pro Arg Leu Ala Gln Leu Leu Thr Thr Ile Pro Leu Pro Val Val 
            420                 425                 430         


Gly Gly Val Leu Gly Val Thr Gln Ala Val Val Leu Ser Ala Gly Phe 
        435                 440                 445             


Ser Ser Phe Tyr Leu Ala Asp Ile Asp Ser Gly Arg Asn Ile Phe Ile 
    450                 455                 460                 


Val Gly Phe Ser Ile Phe Met Ala Leu Leu Leu Pro Arg Trp Phe Arg 
465                 470                 475                 480 


Glu Ala Pro Val Leu Phe Ser Thr Gly Trp Ser Pro Leu Asp Val Leu 
                485                 490                 495     


Leu His Ser Leu Leu Thr Gln Pro Ile Phe Leu Ala Gly Leu Ser Gly 
            500                 505                 510         


Phe Leu Leu Glu Asn Thr Ile Pro Gly Thr Gln Leu Glu Arg Gly Leu 
        515                 520                 525             


Gly Gln Gly Leu Pro Ser Pro Phe Thr Ala Gln Glu Ala Arg Met Pro 
    530                 535                 540                 


Gln Lys Pro Arg Glu Lys Ala Ala Gln Val Tyr Arg Leu Pro Phe Pro 
545                 550                 555                 560 


Ile Gln Asn Leu Cys Pro Cys Ile Pro Gln Pro Leu His Cys Leu Cys 
                565                 570                 575     


Pro Leu Pro Glu Asp Pro Gly Asp Glu Glu Gly Gly Ser Ser Glu Pro 
            580                 585                 590         


Glu Glu Met Ala Asp Leu Leu Pro Gly Ser Gly Glu Pro Cys Pro Glu 
        595                 600                 605             


Ser Ser Arg Glu Gly Phe Arg Ser Gln Lys 
    610                 615             


<210>  1782
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  1782

Met Ala Glu Phe Ser Gln Lys Arg Gly Lys Arg Arg Ser Asp Glu Gly 
1               5                   10                  15      


Leu Gly Ser Met Val Asp Phe Leu Leu Ala Asn Ala Arg Leu Val Leu 
            20                  25                  30          


Gly Val Gly Gly Ala Ala Val Leu Gly Ile Ala Thr Leu Ala Val Lys 
        35                  40                  45              


Arg Phe Ile Asp Arg Ala Thr Ser Pro Arg Asp Glu Asp Asp Thr Lys 
    50                  55                  60                  


Ala Asp Ser Trp Lys Glu Leu Ser Leu Leu Lys Ala Thr Pro His Leu 
65                  70                  75                  80  


Gln Pro Arg Pro Pro Pro Ala Ala Leu Ser Gln Pro Val Leu Pro Leu 
                85                  90                  95      


Ala Pro Ser Ser Ser Ala Pro Gly Glu Ala Ala Gly Leu Arg Ala Gly 
            100                 105                 110         


Pro Cys Asp His Pro Ser Ser Pro Gly Gly Phe Gly Gln Thr Ala Gly 
        115                 120                 125             


Trp Arg His Arg Pro Gly Ala Ala Gly Leu Leu Ser Glu Gln Val Pro 
    130                 135                 140                 


Gly Thr Ala Leu Trp Gly Ile Arg Ala Trp Gly Ala Ala Leu Arg Arg 
145                 150                 155                 160 


Ala Ala Gly Gly Gly Cys Gly Pro Cys Ala Ser Pro Gly Ala Thr Gly 
                165                 170                 175     


Ala Gly Ala Gly Pro Val Glu Pro Gly Ala Gly Arg Gly His Cys Gly 
            180                 185                 190         


Glu Gly Pro Ser Leu Leu Gly Arg Ala Gln Asp Ala Ala 
        195                 200                 205 


<210>  1783
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  1783

Met Ser Ala Ser Ala Ala Thr Gly Val Phe Val Leu Ser Leu Ser Ala 
1               5                   10                  15      


Ile Pro Val Thr Tyr Val Phe Asn His Leu Ala Ala Gln His Asp Ser 
            20                  25                  30          


Trp Thr Ile Val Gly Val Ala Ala Leu Ile Leu Phe Leu Val Ala Leu 
        35                  40                  45              


Leu Ala Arg Val Leu Val Lys Arg Lys Pro Pro Arg Asp Pro Leu Phe 
    50                  55                  60                  


Tyr Val Tyr Ala Val Phe Gly Phe Thr Ser Val Val Asn Leu Ile Ile 
65                  70                  75                  80  


Gly Leu Glu Gln Asp Gly Ile Ile Asp Gly Phe Met Thr His Tyr Leu 
                85                  90                  95      


Arg Glu Gly Glu Pro Tyr Leu Asn Thr Ala Tyr Gly His Met Ile Cys 
            100                 105                 110         


Tyr Trp Asp Gly Ser Ala His Tyr Leu Met Tyr Leu Val Met Val Ala 
        115                 120                 125             


Ala Ile Ala Trp Glu Glu Thr Tyr Arg Thr Ile Gly Leu Tyr Trp Val 
    130                 135                 140                 


Gly Ser Ile Ile Met Ser Val Val Val Phe Val Pro Gly Asn Ile Val 
145                 150                 155                 160 


Gly Lys Tyr Gly Thr Arg Ile Cys Pro Ala Phe Phe Leu Ser Ile Pro 
                165                 170                 175     


Tyr Thr Cys Leu Pro Val Trp Ala Gly Phe Arg Ile Tyr Asn Gln Pro 
            180                 185                 190         


Ser Glu Asn Tyr Asn Tyr Pro Ser Lys Val Ile Gln Glu Ala Gln Ala 
        195                 200                 205             


Lys Asp Leu Leu Arg Arg Pro Phe Asp Leu Met Leu Val Val Cys Leu 
    210                 215                 220                 


Leu Leu Ala Thr Gly Phe Cys Leu Phe Arg Gly Leu Met Leu Ala Tyr 
225                 230                 235                 240 


Met Phe Tyr Ser Val Pro Tyr Phe Val Thr Ala Leu Tyr Gly Leu Val 
                245                 250                 255     


Val Pro Gly Cys Ser Trp Met Pro Asp Ile Thr Leu Ile His Ala Gly 
            260                 265                 270         


Gly Leu Ala Gln Ala Gln Phe Ser His Ile Gly Ala Ser Leu His Ala 
        275                 280                 285             


Arg Thr Ala Tyr Val Tyr Arg Val Pro Glu Glu Ala Lys Ile Leu Phe 
    290                 295                 300                 


Leu Ala Leu Asn Ile Ala Tyr Gly Val Leu Pro Gln Leu Leu Ala Tyr 
305                 310                 315                 320 


Arg Cys Ile Tyr Lys Pro Glu Phe Phe Ile Lys Thr Lys Ala Glu Glu 
                325                 330                 335     


Lys Val Glu 
            


<210>  1784
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  1784

Met Ser Asp Ser Lys Glu Pro Arg Val Gln Gln Leu Gly Leu Leu Gly 
1               5                   10                  15      


Cys Leu Gly His Gly Ala Leu Val Leu Gln Leu Leu Ser Phe Met Leu 
            20                  25                  30          


Leu Ala Gly Val Leu Val Ala Ile Leu Val Gln Val Ser Lys Val Pro 
        35                  40                  45              


Ser Ser Leu Ser Gln Glu Gln Ser Glu Gln Asp Ala Ile Tyr Gln Asn 
    50                  55                  60                  


Leu Thr Gln Leu Lys Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys 
65                  70                  75                  80  


Leu Gln Glu Ile Tyr Gln Glu Leu Thr Gln Leu Lys Ala Ala Val Gly 
                85                  90                  95      


Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr 
            100                 105                 110         


Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln 
        115                 120                 125             


Glu Ile Tyr Gln Glu Leu Thr Arg Leu Lys Ala Ala Val Gly Glu Leu 
    130                 135                 140                 


Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr Glu Leu 
145                 150                 155                 160 


Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile 
                165                 170                 175     


Tyr Gln Glu Leu Thr Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Asp 
            180                 185                 190         


Gln Ser Lys Gln Gln Gln Ile Tyr Gln Glu Leu Thr Asp Leu Lys Thr 
        195                 200                 205             


Ala Phe Glu Arg Leu Cys Arg His Cys Pro Lys Asp Trp Thr Phe Phe 
    210                 215                 220                 


Gln Gly Asn Cys Tyr Phe Met Ser Asn Ser Gln Arg Asn Trp His Asp 
225                 230                 235                 240 


Ser Val Thr Ala Cys Gln Glu Val Arg Ala Gln Leu Val Val Ile Lys 
                245                 250                 255     


Thr Ala Glu Glu Gln Asn Phe Leu Gln Leu Gln Thr Ser Arg Ser Asn 
            260                 265                 270         


Arg Phe Ser Trp Met Gly Leu Ser Asp Leu Asn Gln Glu Gly Thr Trp 
        275                 280                 285             


Gln Trp Val Asp Gly Ser Pro Leu Ser Pro Ser Phe Gln Arg Tyr Trp 
    290                 295                 300                 


Asn Ser Gly Glu Pro Asn Asn Ser Gly Asn Glu Asp Cys Ala Glu Phe 
305                 310                 315                 320 


Ser Gly Ser Gly Trp Asn Asp Asn Arg Cys Asp Val Asp Asn Tyr Trp 
                325                 330                 335     


Ile Cys Lys Lys Pro Ala Ala Cys Phe Arg Asp Glu 
            340                 345             


<210>  1785
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  1785

Met Ser Asp Ser Lys Glu Pro Arg Val Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Asp Pro Thr Thr Ser Gly Ile Arg Leu Phe Pro Arg Asp Phe Gln Phe 
            20                  25                  30          


Gln Gln Ile His Gly His Lys Ser Ser Thr Gly Cys Leu Gly His Gly 
        35                  40                  45              


Ala Leu Val Leu Gln Leu Leu Ser Phe Met Leu Leu Ala Gly Val Leu 
    50                  55                  60                  


Val Ala Ile Leu Val Gln Val Ser Lys Val Pro Ser Ser Leu Ser Gln 
65                  70                  75                  80  


Glu Gln Ser Glu Gln Asp Ala Ile Tyr Gln Asn Leu Thr Gln Leu Lys 
                85                  90                  95      


Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys Leu Gln Glu Ile Tyr 
            100                 105                 110         


Gln Glu Leu Thr Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys 
        115                 120                 125             


Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr Arg Leu Lys Ala Ala 
    130                 135                 140                 


Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu 
145                 150                 155                 160 


Leu Thr Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys 
                165                 170                 175     


Leu Gln Glu Ile Tyr Gln Glu Leu Thr Glu Leu Lys Ala Ala Val Gly 
            180                 185                 190         


Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr 
        195                 200                 205             


Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Asp Gln Ser Lys Gln Gln 
    210                 215                 220                 


Gln Ile Tyr Gln Glu Leu Thr Asp Leu Lys Thr Ala Phe Glu Arg Leu 
225                 230                 235                 240 


Cys Arg His Cys Pro Lys Asp Trp Thr Phe Phe Gln Gly Asn Cys Tyr 
                245                 250                 255     


Phe Met Ser Asn Ser Gln Arg Asn Trp His Asp Ser Val Thr Ala Cys 
            260                 265                 270         


Gln Glu Val Arg Ala Gln Leu Val Val Ile Lys Thr Ala Glu Glu Gln 
        275                 280                 285             


Asn Phe Leu Gln Leu Gln Thr Ser Arg Ser Asn Arg Phe Ser Trp Met 
    290                 295                 300                 


Gly Leu Ser Asp Leu Asn Gln Glu Gly Thr Trp Gln Trp Val Asp Gly 
305                 310                 315                 320 


Ser Pro Leu Ser Pro Ser Phe Gln Arg Tyr Trp Asn Ser Gly Glu Pro 
                325                 330                 335     


Asn Asn Ser Gly Asn Glu Asp Cys Ala Glu Phe Ser Gly Ser Gly Trp 
            340                 345                 350         


Asn Asp Asn Arg Cys Asp Val Asp Asn Tyr Trp Ile Cys Lys Lys Pro 
        355                 360                 365             


Ala Ala Cys Phe Arg Asp Glu 
    370                 375 


<210>  1786
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  1786

Met Ser Asp Ser Lys Glu Pro Arg Val Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Asp Pro Thr Thr Ser Gly Ile Arg Leu Phe Pro Arg Asp Phe Gln 
            20                  25                  30          


Phe Gln Gln Ile His Gly His Lys Ser Ser Thr Val Pro Phe Leu Leu 
        35                  40                  45              


Gly Pro Val Ser Lys Val Pro Ser Ser Leu Ser Gln Glu Gln Ser Glu 
    50                  55                  60                  


Gln Asp Ala Ile Tyr Gln Asn Leu Thr Gln Leu Lys Ala Ala Val Gly 
65                  70                  75                  80  


Glu Leu Ser Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr 
                85                  90                  95      


Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln 
            100                 105                 110         


Glu Ile Tyr Gln Glu Leu Thr Arg Leu Lys Ala Ala Val Glu Arg Leu 
        115                 120                 125             


Cys Arg His Cys Pro Lys Asp Trp Thr Phe Phe Gln Gly Asn Cys Tyr 
    130                 135                 140                 


Phe Met Ser Asn Ser Gln Arg Asn Trp His Asp Ser Val Thr Ala Cys 
145                 150                 155                 160 


Gln Glu Val Arg Ala Gln Leu Val Val Ile Lys Thr Ala Glu Glu Gln 
                165                 170                 175     


Asn Phe Leu Gln Leu Gln Thr Ser Arg Ser Asn Arg Phe Ser Trp Met 
            180                 185                 190         


Gly Leu Ser Asp Leu Asn Gln Glu Gly Thr Trp Gln Trp Val Asp Gly 
        195                 200                 205             


Ser Pro Leu Ser Pro Ser Phe Gln Arg Tyr Trp Asn Ser Gly Glu Pro 
    210                 215                 220                 


Asn Asn Ser Gly Asn Glu Asp Cys Ala Glu Phe Ser Gly Ser Gly Trp 
225                 230                 235                 240 


Asn Asp Asn Arg Cys Asp Val Asp Asn Tyr Trp Ile Cys Lys Lys Pro 
                245                 250                 255     


Ala Ala Cys Phe Arg Asp Glu 
            260             


<210>  1787
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  1787

Met Ser Asp Ser Lys Glu Pro Arg Val Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Asp Pro Thr Thr Ser Gly Ile Arg Leu Phe Pro Arg Asp Phe Gln 
            20                  25                  30          


Phe Gln Gln Ile His Gly His Lys Ser Ser Thr Val Pro Phe Leu Leu 
        35                  40                  45              


Gly Pro Val Ser Lys Val Pro Ser Ser Leu Ser Gln Glu Gln Ser Glu 
    50                  55                  60                  


Gln Asp Ala Ile Tyr Gln Asn Leu Thr Gln Leu Lys Ala Ala Val Gly 
65                  70                  75                  80  


Glu Leu Ser Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr 
                85                  90                  95      


Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln 
            100                 105                 110         


Glu Ile Tyr Gln Glu Leu Thr Arg Leu Lys Ala Ala Val Gly Glu Leu 
        115                 120                 125             


Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr Arg Leu 
    130                 135                 140                 


Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile 
145                 150                 155                 160 


Tyr Gln Glu Leu Thr Glu Leu Lys Ala Ala Val Gly Glu Leu Pro Glu 
                165                 170                 175     


Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr Gln Leu Lys Ala 
            180                 185                 190         


Ala Val Glu Arg Leu Cys Arg His Cys Pro Lys Asp Trp Thr Phe Phe 
        195                 200                 205             


Gln Gly Asn Cys Tyr Phe Met Ser Asn Ser Gln Arg Asn Trp His Asp 
    210                 215                 220                 


Ser Val Thr Ala Cys Gln Glu Val Arg Ala Gln Leu Val Val Ile Lys 
225                 230                 235                 240 


Thr Ala Glu Glu Gln Asn Phe Leu Gln Leu Gln Thr Ser Arg Ser Asn 
                245                 250                 255     


Arg Phe Ser Trp Met Gly Leu Ser Asp Leu Asn Gln Glu Gly Thr Trp 
            260                 265                 270         


Gln Trp Val Asp Gly Ser Pro Leu Ser Pro Ser Phe Gln Arg Tyr Trp 
        275                 280                 285             


Asn Ser Gly Glu Pro Asn Asn Ser Gly Asn Glu Asp Cys Ala Glu Phe 
    290                 295                 300                 


Ser Gly Ser Gly Trp Asn Asp Asn Arg Cys Asp Val Asp Asn Tyr Trp 
305                 310                 315                 320 


Ile Cys Lys Lys Pro Ala Ala Cys Phe Arg Asp Glu 
                325                 330         


<210>  1788
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  1788

Met Ser Asp Ser Lys Glu Pro Arg Val Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Asp Pro Thr Thr Ser Gly Ile Arg Leu Phe Pro Arg Asp Phe Gln 
            20                  25                  30          


Phe Gln Gln Ile His Gly His Lys Ser Ser Thr Gly Cys Leu Gly His 
        35                  40                  45              


Gly Ala Leu Val Leu Gln Leu Leu Ser Phe Met Leu Leu Ala Gly Val 
    50                  55                  60                  


Leu Val Ala Ile Leu Val Gln Val Ser Lys Val Pro Ser Ser Leu Ser 
65                  70                  75                  80  


Gln Glu Gln Ser Glu Gln Asp Ala Ile Tyr Gln Asn Leu Thr Gln Leu 
                85                  90                  95      


Lys Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys Leu Gln Glu Ile 
            100                 105                 110         


Tyr Gln Glu Leu Thr Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Glu 
        115                 120                 125             


Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr Arg Leu Lys Ala 
    130                 135                 140                 


Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln 
145                 150                 155                 160 


Glu Leu Thr Arg Leu Lys Ala Ala Val Glu Arg Leu Cys Arg His Cys 
                165                 170                 175     


Pro Lys Asp Trp Thr Phe Phe Gln Gly Asn Cys Tyr Phe Met Ser Asn 
            180                 185                 190         


Ser Gln Arg Asn Trp His Asp Ser Val Thr Ala Cys Gln Glu Val Arg 
        195                 200                 205             


Ala Gln Leu Val Val Ile Lys Thr Ala Glu Glu Gln Leu Pro Ala Val 
    210                 215                 220                 


Leu Glu Gln Trp Arg Thr Gln Gln 
225                 230         


<210>  1789
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  1789

Met Ser Asp Ser Lys Glu Pro Arg Val Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Asp Pro Thr Thr Ser Gly Ile Arg Leu Phe Pro Arg Asp Phe Gln 
            20                  25                  30          


Phe Gln Gln Ile His Gly His Lys Ser Ser Thr Gly Cys Leu Gly His 
        35                  40                  45              


Gly Ala Leu Val Leu Gln Leu Leu Ser Phe Met Leu Leu Ala Gly Val 
    50                  55                  60                  


Leu Val Ala Ile Leu Val Gln Val Ser Lys Val Pro Ser Ser Leu Ser 
65                  70                  75                  80  


Gln Glu Gln Ser Glu Gln Asp Ala Ile Tyr Gln Asn Leu Thr Gln Leu 
                85                  90                  95      


Lys Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys Leu Gln Glu Ile 
            100                 105                 110         


Tyr Gln Glu Leu Thr Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Glu 
        115                 120                 125             


Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr Arg Leu Lys Ala 
    130                 135                 140                 


Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln 
145                 150                 155                 160 


Glu Leu Thr Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser 
                165                 170                 175     


Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr Gln Leu Lys Ala Ala Val 
            180                 185                 190         


Gly Glu Leu Pro Asp Gln Ser Lys Gln Gln Gln Ile Tyr Gln Glu Leu 
        195                 200                 205             


Thr Asp Leu Lys Thr Ala Phe Glu Arg Leu Cys Arg His Cys Pro Lys 
    210                 215                 220                 


Asp Trp Thr Phe Phe Gln Gly Asn Cys Tyr Phe Met Ser Asn Ser Gln 
225                 230                 235                 240 


Arg Asn Trp His Asp Ser Val Thr Ala Cys Gln Glu Val Arg Ala Gln 
                245                 250                 255     


Leu Val Val Ile Lys Thr Ala Glu Glu Gln Asn Phe Leu Gln Leu Gln 
            260                 265                 270         


Thr Ser Arg Ser Asn Arg Phe Ser Trp Met Gly Leu Ser Asp Leu Asn 
        275                 280                 285             


Gln Glu Gly Thr Trp Gln Trp Val Asp Gly Ser Pro Leu Ser Pro Ser 
    290                 295                 300                 


Phe Gln Arg Tyr Trp Asn Ser Gly Glu Pro Asn Asn Ser Gly Asn Glu 
305                 310                 315                 320 


Asp Cys Ala Glu Phe Ser Gly Ser Gly Trp Asn Asp Asn Arg Cys Asp 
                325                 330                 335     


Val Asp Asn Tyr Trp Ile Cys Lys Lys Pro Ala Ala Cys Phe Arg Asp 
            340                 345                 350         


Glu 
    


<210>  1790
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  1790

Met Ser Asp Ser Lys Glu Pro Arg Val Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Asp Pro Thr Thr Ser Gly Ile Arg Leu Phe Pro Arg Asp Phe Gln 
            20                  25                  30          


Phe Gln Gln Ile His Gly His Lys Ser Ser Thr Gly Cys Leu Gly His 
        35                  40                  45              


Gly Ala Leu Val Leu Gln Leu Leu Ser Phe Met Leu Leu Ala Gly Val 
    50                  55                  60                  


Leu Val Ala Ile Leu Val Gln Val Ser Lys Val Pro Ser Ser Leu Ser 
65                  70                  75                  80  


Gln Glu Gln Ser Glu Gln Asp Ala Ile Tyr Gln Asn Leu Thr Gln Leu 
                85                  90                  95      


Lys Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys Leu Gln Glu Ile 
            100                 105                 110         


Tyr Gln Glu Leu Thr Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Glu 
        115                 120                 125             


Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr Arg Leu Lys Ala 
    130                 135                 140                 


Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln 
145                 150                 155                 160 


Glu Leu Thr Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser 
                165                 170                 175     


Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr Glu Leu Lys Ala Ala Val 
            180                 185                 190         


Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu 
        195                 200                 205             


Thr Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Asp Gln Ser Lys Gln 
    210                 215                 220                 


Gln Gln Ile Tyr Gln Glu Leu Thr Asp Leu Lys Thr Ala Phe Glu Arg 
225                 230                 235                 240 


Leu Cys Arg His Cys Pro Lys Asp Trp Thr Phe Phe Gln Gly Asn Cys 
                245                 250                 255     


Tyr Phe Met Ser Asn Ser Gln Arg Asn Trp His Asp Ser Val Thr Ala 
            260                 265                 270         


Cys Gln Glu Val Arg Ala Gln Leu Val Val Ile Lys Thr Ala Glu Glu 
        275                 280                 285             


Gln Asn Phe Leu Gln Leu Gln Thr Ser Arg Ser Asn Arg Phe Ser Trp 
    290                 295                 300                 


Met Gly Leu Ser Asp Leu Asn Gln Glu Gly Thr Trp Gln Trp Val Asp 
305                 310                 315                 320 


Gly Ser Pro Leu Ser Pro Ser Phe Gln Arg Tyr Trp Asn Ser Gly Glu 
                325                 330                 335     


Pro Asn Asn Ser Gly Asn Glu Asp Cys Ala Glu Phe Ser Gly Ser Gly 
            340                 345                 350         


Trp Asn Asp Asn Arg Cys Asp Val Asp Asn Tyr Trp Ile Cys Lys Lys 
        355                 360                 365             


Pro Ala Ala Cys Phe Arg Asp Glu 
    370                 375     


<210>  1791
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  1791

Met Ser Asp Ser Lys Glu Pro Arg Val Gln Gln Leu Gly Leu Leu Gly 
1               5                   10                  15      


Cys Leu Gly His Gly Ala Leu Val Leu Gln Leu Leu Ser Phe Met Leu 
            20                  25                  30          


Leu Ala Gly Val Leu Val Ala Ile Leu Val Gln Val Ser Lys Val Pro 
        35                  40                  45              


Ser Ser Leu Ser Gln Glu Gln Ser Glu Gln Asp Ala Ile Tyr Gln Asn 
    50                  55                  60                  


Leu Thr Gln Leu Lys Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys 
65                  70                  75                  80  


Leu Gln Glu Ile Tyr Gln Glu Leu Thr Gln Leu Lys Ala Ala Val Gly 
                85                  90                  95      


Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr 
            100                 105                 110         


Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln 
        115                 120                 125             


Glu Ile Tyr Gln Glu Leu Thr Arg Leu Lys Ala Ala Val Gly Glu Leu 
    130                 135                 140                 


Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr Arg Leu 
145                 150                 155                 160 


Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile 
                165                 170                 175     


Tyr Gln Glu Leu Thr Glu Leu Lys Ala Ala Val Gly Glu Leu Pro Glu 
            180                 185                 190         


Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr Gln Leu Lys Ala 
        195                 200                 205             


Ala Val Gly Glu Leu Pro Asp Gln Ser Lys Gln Gln Gln Ile Tyr Gln 
    210                 215                 220                 


Glu Leu Thr Asp Leu Lys Thr Ala Phe Glu Arg Leu Cys Arg His Cys 
225                 230                 235                 240 


Pro Lys Asp Trp Thr Phe Phe Gln Gly Asn Cys Tyr Phe Met Ser Asn 
                245                 250                 255     


Ser Gln Arg Asn Trp His Asp Ser Val Thr Ala Cys Gln Glu Val Arg 
            260                 265                 270         


Ala Gln Leu Val Val Ile Lys Thr Ala Glu Glu Gln Leu Pro Ala Val 
        275                 280                 285             


Leu Glu Gln Trp Arg Thr Gln Gln 
    290                 295     


<210>  1792
<211>  769
<212>  PRT
<213>  Homo sapiens

<400>  1792

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              


Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu 
    50                  55                  60                  


Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
65                  70                  75                  80  


Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                85                  90                  95      


Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr 
            100                 105                 110         


Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile 
        115                 120                 125             


Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val 
    130                 135                 140                 


Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
145                 150                 155                 160 


Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys 
                165                 170                 175     


Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu 
            180                 185                 190         


Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             


Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
    210                 215                 220                 


Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile 
225                 230                 235                 240 


Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro 
                245                 250                 255     


Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly 
            260                 265                 270         


Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile 
        275                 280                 285             


Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp 
    290                 295                 300                 


Gly Leu Pro Tyr Leu Lys Val Leu Lys His Ser Gly Ile Asn Ser Ser 
305                 310                 315                 320 


Asn Ala Glu Val Leu Ala Leu Phe Asn Val Thr Glu Ala Asp Ala Gly 
                325                 330                 335     


Glu Tyr Ile Cys Lys Val Ser Asn Tyr Ile Gly Gln Ala Asn Gln Ser 
            340                 345                 350         


Ala Trp Leu Thr Val Leu Pro Lys Gln Gln Ala Pro Gly Arg Glu Lys 
        355                 360                 365             


Glu Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile 
    370                 375                 380                 


Gly Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg 
385                 390                 395                 400 


Met Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val 
                405                 410                 415     


His Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser 
            420                 425                 430         


Ala Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile 
        435                 440                 445             


Thr Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val 
    450                 455                 460                 


Ser Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp 
465                 470                 475                 480 


Lys Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val 
                485                 490                 495     


Val Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala 
            500                 505                 510         


Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp 
        515                 520                 525             


Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys 
    530                 535                 540                 


His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro 
545                 550                 555                 560 


Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr 
                565                 570                 575     


Leu Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn 
            580                 585                 590         


Arg Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr 
        595                 600                 605             


Tyr Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile 
    610                 615                 620                 


His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val 
625                 630                 635                 640 


Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp 
                645                 650                 655     


Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala 
            660                 665                 670         


Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp 
        675                 680                 685             


Ser Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro 
    690                 695                 700                 


Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly 
705                 710                 715                 720 


His Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met 
                725                 730                 735     


Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys 
            740                 745                 750         


Gln Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu 
        755                 760                 765             


Ile 
    


<210>  1793
<211>  709
<212>  PRT
<213>  Homo sapiens

<400>  1793

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              


Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu 
    50                  55                  60                  


Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
65                  70                  75                  80  


Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                85                  90                  95      


Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr 
            100                 105                 110         


Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile 
        115                 120                 125             


Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val 
    130                 135                 140                 


Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
145                 150                 155                 160 


Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys 
                165                 170                 175     


Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu 
            180                 185                 190         


Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             


Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
    210                 215                 220                 


Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile 
225                 230                 235                 240 


Asn His Thr Tyr His Leu Asp Val Val Ala Pro Gly Arg Glu Lys Glu 
                245                 250                 255     


Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly 
            260                 265                 270         


Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg Met 
        275                 280                 285             


Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His 
    290                 295                 300                 


Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala 
305                 310                 315                 320 


Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr 
                325                 330                 335     


Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser 
            340                 345                 350         


Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys 
        355                 360                 365             


Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val 
    370                 375                 380                 


Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val 
385                 390                 395                 400 


Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu 
                405                 410                 415     


Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His 
            420                 425                 430         


Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu 
        435                 440                 445             


Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu 
    450                 455                 460                 


Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg 
465                 470                 475                 480 


Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr 
                485                 490                 495     


Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His 
            500                 505                 510         


Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met 
        515                 520                 525             


Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr 
    530                 535                 540                 


Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro 
545                 550                 555                 560 


Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser 
                565                 570                 575     


Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr 
            580                 585                 590         


Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His 
        595                 600                 605             


Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met 
    610                 615                 620                 


Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln 
625                 630                 635                 640 


Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu 
                645                 650                 655     


Tyr Leu Asp Leu Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro 
            660                 665                 670         


Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro 
        675                 680                 685             


Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn 
    690                 695                 700                 


Gly Ser Val Lys Thr 
705                 


<210>  1794
<211>  707
<212>  PRT
<213>  Homo sapiens

<400>  1794

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Asp Ala Ile Ser Ser Gly Asp Asp Glu Asp Asp Thr 
        35                  40                  45              


Asp Gly Ala Glu Asp Phe Val Ser Glu Asn Ser Asn Asn Lys Arg Ala 
    50                  55                  60                  


Pro Tyr Trp Thr Asn Thr Glu Lys Met Glu Lys Arg Leu His Ala Val 
65                  70                  75                  80  


Pro Ala Ala Asn Thr Val Lys Phe Arg Cys Pro Ala Gly Gly Asn Pro 
                85                  90                  95      


Met Pro Thr Met Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Gln Glu 
            100                 105                 110         


His Arg Ile Gly Gly Tyr Lys Val Arg Asn Gln His Trp Ser Leu Ile 
        115                 120                 125             


Met Glu Ser Val Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Val Val 
    130                 135                 140                 


Glu Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr His Leu Asp Val Val 
145                 150                 155                 160 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
                165                 170                 175     


Ala Ser Thr Val Val Gly Gly Asp Val Glu Phe Val Cys Lys Val Tyr 
            180                 185                 190         


Ser Asp Ala Gln Pro His Ile Gln Trp Ile Lys His Val Glu Lys Asn 
        195                 200                 205             


Gly Ser Lys Tyr Gly Pro Asp Gly Leu Pro Tyr Leu Lys Val Leu Lys 
    210                 215                 220                 


Ala Ala Gly Val Asn Thr Thr Asp Lys Glu Ile Glu Val Leu Tyr Ile 
225                 230                 235                 240 


Arg Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                245                 250                 255     


Asn Ser Ile Gly Ile Ser Phe His Ser Ala Trp Leu Thr Val Leu Pro 
            260                 265                 270         


Ala Pro Gly Arg Glu Lys Glu Ile Thr Ala Ser Pro Asp Tyr Leu Glu 
        275                 280                 285             


Ile Ala Ile Tyr Cys Ile Gly Val Phe Leu Ile Ala Cys Met Val Val 
    290                 295                 300                 


Thr Val Ile Leu Cys Arg Met Lys Asn Thr Thr Lys Lys Pro Asp Phe 
305                 310                 315                 320 


Ser Ser Gln Pro Ala Val His Lys Leu Thr Lys Arg Ile Pro Leu Arg 
                325                 330                 335     


Arg Gln Val Thr Val Ser Ala Glu Ser Ser Ser Ser Met Asn Ser Asn 
            340                 345                 350         


Thr Pro Leu Val Arg Ile Thr Thr Arg Leu Ser Ser Thr Ala Asp Thr 
        355                 360                 365             


Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro Glu Asp Pro Lys 
    370                 375                 380                 


Trp Glu Phe Pro Arg Asp Lys Leu Thr Leu Gly Lys Pro Leu Gly Glu 
385                 390                 395                 400 


Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Val Gly Ile Asp Lys 
                405                 410                 415     


Asp Lys Pro Lys Glu Ala Val Thr Val Ala Val Lys Met Leu Lys Asp 
            420                 425                 430         


Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met 
        435                 440                 445             


Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala 
    450                 455                 460                 


Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys 
465                 470                 475                 480 


Gly Asn Leu Arg Glu Tyr Leu Arg Ala Arg Arg Pro Pro Gly Met Glu 
                485                 490                 495     


Tyr Ser Tyr Asp Ile Asn Arg Val Pro Glu Glu Gln Met Thr Phe Lys 
            500                 505                 510         


Asp Leu Val Ser Cys Thr Tyr Gln Leu Ala Arg Gly Met Glu Tyr Leu 
        515                 520                 525             


Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu 
    530                 535                 540                 


Val Thr Glu Asn Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg 
545                 550                 555                 560 


Asp Ile Asn Asn Ile Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu 
                565                 570                 575     


Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr 
            580                 585                 590         


His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Met Trp Glu Ile Phe 
        595                 600                 605             


Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe 
    610                 615                 620                 


Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr 
625                 630                 635                 640 


Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp His Ala Val Pro Ser 
                645                 650                 655     


Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Ile Leu 
            660                 665                 670         


Thr Leu Thr Thr Asn Glu Glu Glu Lys Lys Val Ser Gly Ala Val Asp 
        675                 680                 685             


Cys His Lys Pro Pro Cys Asn Pro Ser His Leu Pro Cys Val Leu Ala 
    690                 695                 700                 


Val Asp Gln 
705         


<210>  1795
<211>  706
<212>  PRT
<213>  Homo sapiens

<400>  1795

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Gly Ala Pro Tyr Trp Thr Asn Thr Glu Lys Met Glu 
        35                  40                  45              


Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys Phe Arg Cys 
    50                  55                  60                  


Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu Lys Asn Gly 
65                  70                  75                  80  


Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys Val Arg Asn 
                85                  90                  95      


Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser Asp Lys Gly 
            100                 105                 110         


Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr 
        115                 120                 125             


Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
    130                 135                 140                 


Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly Asp Val Glu 
145                 150                 155                 160 


Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Ile 
                165                 170                 175     


Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp Gly Leu Pro 
            180                 185                 190         


Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr Asp Lys Glu 
        195                 200                 205             


Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp Ala Gly Glu 
    210                 215                 220                 


Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe His Ser Ala 
225                 230                 235                 240 


Trp Leu Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu Ile Thr Ala 
                245                 250                 255     


Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly Val Phe Leu 
            260                 265                 270         


Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg Met Lys Asn Thr 
        275                 280                 285             


Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His Lys Leu Thr 
    290                 295                 300                 


Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Glu Ser Ser 
305                 310                 315                 320 


Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr Thr Arg Leu 
                325                 330                 335     


Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu 
            340                 345                 350         


Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys Leu Thr Leu 
        355                 360                 365             


Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Met Ala Glu 
    370                 375                 380                 


Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val Thr Val Ala 
385                 390                 395                 400 


Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu 
                405                 410                 415     


Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile 
            420                 425                 430         


Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile 
        435                 440                 445             


Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Arg Ala Arg 
    450                 455                 460                 


Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg Val Pro Glu 
465                 470                 475                 480 


Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr Gln Leu Ala 
                485                 490                 495     


Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His Arg Asp Leu 
            500                 505                 510         


Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met Lys Ile Ala 
        515                 520                 525             


Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr Tyr Lys Lys 
    530                 535                 540                 


Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu 
545                 550                 555                 560 


Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val 
                565                 570                 575     


Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile 
            580                 585                 590         


Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp 
        595                 600                 605             


Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys 
    610                 615                 620                 


Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu 
625                 630                 635                 640 


Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu Tyr Leu Asp 
                645                 650                 655     


Leu Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro Asp Thr Arg 
            660                 665                 670         


Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro Asp Pro Met 
        675                 680                 685             


Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn Gly Ser Val 
    690                 695                 700                 


Lys Thr 
705     


<210>  1796
<211>  705
<212>  PRT
<213>  Homo sapiens

<400>  1796

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              


Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu 
    50                  55                  60                  


Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
65                  70                  75                  80  


Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                85                  90                  95      


Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr 
            100                 105                 110         


Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile 
        115                 120                 125             


Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val 
    130                 135                 140                 


Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
145                 150                 155                 160 


Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys 
                165                 170                 175     


Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu 
            180                 185                 190         


Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             


Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
    210                 215                 220                 


Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile 
225                 230                 235                 240 


Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro 
                245                 250                 255     


Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly 
            260                 265                 270         


Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile 
        275                 280                 285             


Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp 
    290                 295                 300                 


Gly Leu Pro Tyr Leu Lys Val Leu Lys Val Ser Ala Glu Ser Ser Ser 
305                 310                 315                 320 


Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr Thr Arg Leu Ser 
                325                 330                 335     


Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu 
            340                 345                 350         


Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys Leu Thr Leu Gly 
        355                 360                 365             


Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala 
    370                 375                 380                 


Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val Thr Val Ala Val 
385                 390                 395                 400 


Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Val 
                405                 410                 415     


Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile 
            420                 425                 430         


Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val 
        435                 440                 445             


Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Arg Ala Arg Arg 
    450                 455                 460                 


Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg Val Pro Glu Glu 
465                 470                 475                 480 


Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr Gln Leu Ala Arg 
                485                 490                 495     


Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala 
            500                 505                 510         


Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met Lys Ile Ala Asp 
        515                 520                 525             


Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr Tyr Lys Lys Thr 
    530                 535                 540                 


Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe 
545                 550                 555                 560 


Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu 
                565                 570                 575     


Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro 
            580                 585                 590         


Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys 
        595                 600                 605             


Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp 
    610                 615                 620                 


His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp 
625                 630                 635                 640 


Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu Tyr Leu Asp Leu 
                645                 650                 655     


Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro Asp Thr Arg Ser 
            660                 665                 670         


Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro Asp Pro Met Pro 
        675                 680                 685             


Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn Gly Ser Val Lys 
    690                 695                 700                 


Thr 
705 


<210>  1797
<211>  704
<212>  PRT
<213>  Homo sapiens

<400>  1797

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Gly Ala Pro Tyr Trp Thr Asn Thr Glu Lys Met Glu 
        35                  40                  45              


Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys Phe Arg Cys 
    50                  55                  60                  


Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu Lys Asn Gly 
65                  70                  75                  80  


Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys Val Arg Asn 
                85                  90                  95      


Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser Asp Lys Gly 
            100                 105                 110         


Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr 
        115                 120                 125             


Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
    130                 135                 140                 


Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly Asp Val Glu 
145                 150                 155                 160 


Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Ile 
                165                 170                 175     


Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp Gly Leu Pro 
            180                 185                 190         


Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr Asp Lys Glu 
        195                 200                 205             


Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp Ala Gly Glu 
    210                 215                 220                 


Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe His Ser Ala 
225                 230                 235                 240 


Trp Leu Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu Ile Thr Ala 
                245                 250                 255     


Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly Val Phe Leu 
            260                 265                 270         


Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg Met Lys Asn Thr 
        275                 280                 285             


Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His Lys Leu Thr 
    290                 295                 300                 


Lys Arg Ile Pro Leu Arg Arg Gln Val Ser Ala Glu Ser Ser Ser Ser 
305                 310                 315                 320 


Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr Thr Arg Leu Ser Ser 
                325                 330                 335     


Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro 
            340                 345                 350         


Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys Leu Thr Leu Gly Lys 
        355                 360                 365             


Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Val 
    370                 375                 380                 


Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val Thr Val Ala Val Lys 
385                 390                 395                 400 


Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Val Ser 
                405                 410                 415     


Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn 
            420                 425                 430         


Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu 
        435                 440                 445             


Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Arg Ala Arg Arg Pro 
    450                 455                 460                 


Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg Val Pro Glu Glu Gln 
465                 470                 475                 480 


Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr Gln Leu Ala Arg Gly 
                485                 490                 495     


Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala 
            500                 505                 510         


Arg Asn Val Leu Val Thr Glu Asn Asn Val Met Lys Ile Ala Asp Phe 
        515                 520                 525             


Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr Tyr Lys Lys Thr Thr 
    530                 535                 540                 


Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp 
545                 550                 555                 560 


Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Met 
                565                 570                 575     


Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val 
            580                 585                 590         


Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro 
        595                 600                 605             


Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp His 
    610                 615                 620                 


Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu 
625                 630                 635                 640 


Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu Tyr Leu Asp Leu Ser 
                645                 650                 655     


Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro Asp Thr Arg Ser Ser 
            660                 665                 670         


Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro Asp Pro Met Pro Tyr 
        675                 680                 685             


Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn Gly Ser Val Lys Thr 
    690                 695                 700                 


<210>  1798
<211>  680
<212>  PRT
<213>  Homo sapiens

<400>  1798

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Asp Ala Ile Ser Ser Gly Asp Asp Glu Asp Asp Thr 
        35                  40                  45              


Asp Gly Ala Glu Asp Phe Val Ser Glu Asn Ser Asn Asn Lys Arg Ala 
    50                  55                  60                  


Pro Tyr Trp Thr Asn Thr Glu Lys Met Glu Lys Arg Leu His Ala Val 
65                  70                  75                  80  


Pro Ala Ala Asn Thr Val Lys Phe Arg Cys Pro Ala Gly Gly Asn Pro 
                85                  90                  95      


Met Pro Thr Met Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Gln Glu 
            100                 105                 110         


His Arg Ile Gly Gly Tyr Lys Val Arg Asn Gln His Trp Ser Leu Ile 
        115                 120                 125             


Met Glu Ser Val Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Val Val 
    130                 135                 140                 


Glu Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr His Leu Asp Val Val 
145                 150                 155                 160 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
                165                 170                 175     


Ala Ser Thr Val Val Gly Gly Asp Val Glu Phe Val Cys Lys Val Tyr 
            180                 185                 190         


Ser Asp Ala Gln Pro His Ile Gln Trp Ile Lys His Val Glu Lys Asn 
        195                 200                 205             


Gly Ser Lys Tyr Gly Pro Asp Gly Leu Pro Tyr Leu Lys Val Leu Lys 
    210                 215                 220                 


His Ser Gly Ile Asn Ser Ser Asn Ala Glu Val Leu Ala Leu Phe Asn 
225                 230                 235                 240 


Val Thr Glu Ala Asp Ala Gly Glu Tyr Ile Cys Lys Val Ser Asn Tyr 
                245                 250                 255     


Ile Gly Gln Ala Asn Gln Ser Ala Trp Leu Thr Val Leu Pro Lys Gln 
            260                 265                 270         


Gln Ala Pro Gly Arg Glu Lys Glu Ile Thr Ala Ser Pro Asp Tyr Leu 
        275                 280                 285             


Glu Ile Ala Ile Tyr Cys Ile Gly Val Phe Leu Ile Ala Cys Met Val 
    290                 295                 300                 


Val Thr Val Ile Leu Cys Arg Met Lys Asn Thr Thr Lys Lys Pro Asp 
305                 310                 315                 320 


Phe Ser Ser Gln Pro Ala Val His Lys Leu Thr Lys Arg Ile Pro Leu 
                325                 330                 335     


Arg Arg Gln Val Thr Val Ser Ala Glu Ser Ser Ser Ser Met Asn Ser 
            340                 345                 350         


Asn Thr Pro Leu Val Arg Ile Thr Thr Arg Leu Ser Ser Thr Ala Asp 
        355                 360                 365             


Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro Glu Asp Pro 
    370                 375                 380                 


Lys Trp Glu Phe Pro Arg Asp Lys Leu Thr Leu Gly Lys Pro Leu Gly 
385                 390                 395                 400 


Glu Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Val Gly Ile Asp 
                405                 410                 415     


Lys Asp Lys Pro Lys Glu Ala Val Thr Val Ala Val Lys Met Leu Lys 
            420                 425                 430         


Asp Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu 
        435                 440                 445             


Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly 
    450                 455                 460                 


Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser 
465                 470                 475                 480 


Lys Gly Asn Leu Arg Glu Tyr Leu Arg Ala Arg Arg Pro Pro Gly Met 
                485                 490                 495     


Glu Tyr Ser Tyr Asp Ile Asn Arg Val Pro Glu Glu Gln Met Thr Phe 
            500                 505                 510         


Lys Asp Leu Val Ser Cys Thr Tyr Gln Leu Ala Arg Gly Met Glu Tyr 
        515                 520                 525             


Leu Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val 
    530                 535                 540                 


Leu Val Thr Glu Asn Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala 
545                 550                 555                 560 


Arg Asp Ile Asn Asn Ile Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg 
                565                 570                 575     


Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr 
            580                 585                 590         


Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Met Trp Glu Ile 
        595                 600                 605             


Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu 
    610                 615                 620                 


Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys 
625                 630                 635                 640 


Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp His Ala Val Pro 
                645                 650                 655     


Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Ile 
            660                 665                 670         


Leu Thr Leu Thr Thr Asn Glu Ile 
        675                 680 


<210>  1799
<211>  2172
<212>  PRT
<213>  Homo sapiens

<400>  1799

Met Trp Gly Leu Leu Ile Trp Thr Leu Leu Ala Leu His Gln Ile Arg 
1               5                   10                  15      


Ala Ala Arg Ala Gln Asp Asp Val Ser Pro Tyr Phe Lys Thr Glu Pro 
            20                  25                  30          


Val Arg Thr Gln Val His Leu Glu Gly Asn Arg Leu Val Leu Thr Cys 
        35                  40                  45              


Met Ala Glu Gly Ser Trp Pro Leu Glu Phe Lys Trp Leu His Asn Asn 
    50                  55                  60                  


Arg Glu Leu Thr Lys Phe Ser Leu Glu Tyr Arg Tyr Met Ile Thr Ser 
65                  70                  75                  80  


Leu Asp Arg Thr His Ala Gly Phe Tyr Arg Cys Ile Val Arg Asn Arg 
                85                  90                  95      


Met Gly Ala Leu Leu Gln Arg Gln Thr Glu Val Gln Val Ala Tyr Met 
            100                 105                 110         


Gly Ser Phe Glu Glu Gly Glu Lys His Gln Ser Val Ser His Gly Glu 
        115                 120                 125             


Ala Ala Val Ile Arg Ala Pro Arg Ile Ala Ser Phe Pro Gln Pro Gln 
    130                 135                 140                 


Val Thr Trp Phe Arg Asp Gly Arg Lys Ile Pro Pro Ser Ser Arg Ile 
145                 150                 155                 160 


Ala Ile Thr Leu Glu Asn Thr Leu Val Ile Leu Ser Thr Val Ala Pro 
                165                 170                 175     


Asp Ala Gly Arg Tyr Tyr Val Gln Ala Val Asn Asp Lys Asn Gly Asp 
            180                 185                 190         


Asn Lys Thr Ser Gln Pro Ile Thr Leu Thr Val Glu Asn Val Gly Gly 
        195                 200                 205             


Pro Ala Asp Pro Ile Ala Pro Thr Ile Ile Ile Pro Pro Lys Asn Thr 
    210                 215                 220                 


Ser Val Val Ala Gly Thr Ser Glu Val Thr Leu Glu Cys Val Ala Asn 
225                 230                 235                 240 


Ala Arg Pro Leu Ile Lys Leu His Ile Ile Trp Lys Lys Asp Gly Val 
                245                 250                 255     


Leu Leu Ser Gly Gly Ile Ser Asp His Asn Arg Arg Leu Thr Ile Pro 
            260                 265                 270         


Asn Pro Thr Gly Ser Asp Ala Gly Tyr Tyr Glu Cys Glu Ala Val Leu 
        275                 280                 285             


Arg Ser Ser Ser Val Pro Ser Val Val Arg Gly Ala Tyr Leu Ser Val 
    290                 295                 300                 


Leu Glu Pro Pro Gln Phe Val Lys Glu Pro Glu Arg His Ile Thr Ala 
305                 310                 315                 320 


Glu Met Glu Lys Val Val Asp Ile Pro Cys Gln Ala Lys Gly Val Pro 
                325                 330                 335     


Pro Pro Ser Ile Thr Trp Tyr Lys Asp Ala Ala Val Val Glu Val Glu 
            340                 345                 350         


Lys Leu Thr Arg Phe Arg Gln Arg Asn Asp Gly Gly Leu Gln Ile Ser 
        355                 360                 365             


Gly Leu Val Pro Asp Asp Thr Gly Met Phe Gln Cys Phe Ala Arg Asn 
    370                 375                 380                 


Ala Ala Gly Glu Val Gln Thr Ser Thr Tyr Leu Ala Val Thr Ser Ile 
385                 390                 395                 400 


Ala Pro Asn Ile Thr Arg Gly Pro Leu Asp Ser Thr Val Ile Asp Gly 
                405                 410                 415     


Met Ser Val Val Leu Ala Cys Glu Thr Ser Gly Ala Pro Arg Pro Ala 
            420                 425                 430         


Ile Thr Trp Gln Lys Gly Glu Arg Ile Leu Ala Ser Gly Ser Val Gln 
        435                 440                 445             


Leu Pro Arg Phe Thr Pro Leu Glu Ser Gly Ser Leu Leu Ile Ser Pro 
    450                 455                 460                 


Thr His Ile Ser Asp Ala Gly Thr Tyr Thr Cys Leu Ala Thr Asn Ser 
465                 470                 475                 480 


Arg Gly Val Asp Glu Ala Ser Ala Asp Leu Val Val Trp Ala Arg Thr 
                485                 490                 495     


Arg Ile Thr Lys Pro Pro Gln Asp Gln Ser Val Ile Lys Gly Thr Gln 
            500                 505                 510         


Ala Ser Met Val Cys Gly Val Thr His Asp Pro Arg Val Thr Ile Arg 
        515                 520                 525             


Tyr Ile Trp Glu Lys Asp Gly Ala Thr Leu Gly Thr Glu Ser His Pro 
    530                 535                 540                 


Arg Ile Arg Leu Asp Arg Asn Gly Ser Leu His Ile Ser Gln Thr Trp 
545                 550                 555                 560 


Ser Gly Asp Ile Gly Thr Tyr Thr Cys Arg Val Ile Ser Ala Gly Gly 
                565                 570                 575     


Asn Asp Ser Arg Ser Ala His Leu Arg Val Arg Gln Leu Pro His Ala 
            580                 585                 590         


Pro Glu His Pro Val Ala Thr Leu Ser Thr Val Glu Arg Arg Ala Ile 
        595                 600                 605             


Asn Leu Thr Trp Thr Lys Pro Phe Asp Gly Asn Ser Pro Leu Ile Arg 
    610                 615                 620                 


Tyr Ile Leu Glu Met Ser Glu Asn Asn Ala Pro Trp Thr Val Leu Leu 
625                 630                 635                 640 


Ala Ser Val Asp Pro Lys Ala Thr Ser Val Thr Val Lys Gly Leu Val 
                645                 650                 655     


Pro Ala Arg Ser Tyr Gln Phe Arg Leu Cys Ala Val Asn Asp Val Gly 
            660                 665                 670         


Lys Gly Gln Phe Ser Lys Asp Thr Glu Arg Val Ser Leu Pro Glu Glu 
        675                 680                 685             


Pro Pro Thr Ala Pro Pro Gln Asn Val Ile Ala Ser Gly Arg Thr Asn 
    690                 695                 700                 


Gln Ser Ile Met Ile Gln Trp Gln Pro Pro Pro Glu Ser His Gln Asn 
705                 710                 715                 720 


Gly Ile Leu Lys Gly Tyr Ile Ile Arg Tyr Cys Leu Ala Gly Leu Pro 
                725                 730                 735     


Val Gly Tyr Gln Phe Lys Asn Ile Thr Asp Ala Asp Val Asn Asn Leu 
            740                 745                 750         


Leu Leu Glu Asp Leu Ile Ile Trp Thr Asn Tyr Glu Ile Glu Val Ala 
        755                 760                 765             


Ala Tyr Asn Ser Ala Gly Leu Gly Val Tyr Ser Ser Lys Val Thr Glu 
    770                 775                 780                 


Trp Thr Leu Gln Gly Val Pro Thr Val Pro Pro Gly Asn Val His Ala 
785                 790                 795                 800 


Glu Ala Thr Asn Ser Thr Thr Ile Arg Phe Thr Trp Asn Ala Pro Ser 
                805                 810                 815     


Pro Gln Phe Ile Asn Gly Ile Asn Gln Gly Tyr Lys Leu Ile Ala Trp 
            820                 825                 830         


Glu Pro Glu Gln Glu Glu Glu Val Thr Met Val Thr Ala Arg Pro Asn 
        835                 840                 845             


Phe Gln Asp Ser Ile His Val Gly Phe Val Ser Gly Leu Lys Lys Phe 
    850                 855                 860                 


Thr Glu Tyr Phe Thr Ser Val Leu Cys Phe Thr Thr Pro Gly Asp Gly 
865                 870                 875                 880 


Pro Arg Ser Thr Pro Gln Leu Val Arg Thr His Glu Asp Val Pro Gly 
                885                 890                 895     


Pro Val Gly His Leu Ser Phe Ser Glu Ile Leu Asp Thr Ser Leu Lys 
            900                 905                 910         


Val Ser Trp Gln Glu Pro Gly Glu Lys Asn Gly Ile Leu Thr Gly Tyr 
        915                 920                 925             


Arg Ile Ser Trp Glu Glu Tyr Asn Arg Thr Asn Thr Arg Val Thr His 
    930                 935                 940                 


Tyr Leu Pro Asn Val Thr Leu Glu Tyr Arg Val Thr Gly Leu Thr Ala 
945                 950                 955                 960 


Leu Thr Thr Tyr Thr Ile Glu Val Ala Ala Met Thr Ser Lys Gly Gln 
                965                 970                 975     


Gly Gln Val Ser Ala Ser Thr Ile Ser Ser Gly Val Pro Pro Glu Leu 
            980                 985                 990         


Pro Gly Pro Pro Thr Asn Leu Gly  Ile Ser Asn Ile Gly  Pro Arg Ser 
        995                 1000                 1005             


Val Thr  Leu Gln Phe Arg Pro  Gly Tyr Asp Gly Lys  Thr Ser Ile 
    1010                 1015                 1020             


Ser Arg  Trp Leu Val Glu Ala  Gln Val Gly Val Val  Gly Glu Gly 
    1025                 1030                 1035             


Glu Glu  Trp Leu Leu Ile His  Gln Leu Ser Asn Glu  Pro Asp Ala 
    1040                 1045                 1050             


Arg Ser  Met Glu Val Pro Asp  Leu Asn Pro Phe Thr  Cys Tyr Ser 
    1055                 1060                 1065             


Phe Arg  Met Arg Gln Val Asn  Ile Val Gly Thr Ser  Pro Pro Ser 
    1070                 1075                 1080             


Gln Pro  Ser Arg Lys Ile Gln  Thr Leu Gln Ala Pro  Pro Asp Met 
    1085                 1090                 1095             


Ala Pro  Ala Asn Val Ser Leu  Arg Thr Ala Ser Glu  Thr Ser Leu 
    1100                 1105                 1110             


Trp Leu  Arg Trp Met Pro Leu  Pro Glu Met Glu Tyr  Asn Gly Asn 
    1115                 1120                 1125             


Pro Glu  Ser Val Gly Tyr Lys  Ile Lys Tyr Ser Arg  Ser Asp Gly 
    1130                 1135                 1140             


His Gly  Lys Thr Leu Ser His  Val Val Gln Asp Arg  Val Glu Arg 
    1145                 1150                 1155             


Asp Tyr  Thr Ile Glu Asp Leu  Glu Glu Trp Thr Glu  Tyr Arg Val 
    1160                 1165                 1170             


Gln Val  Gln Ala Phe Asn Ala  Ile Gly Ser Gly Pro  Trp Ser Gln 
    1175                 1180                 1185             


Thr Val  Val Gly Arg Thr Arg  Glu Ser Val Pro Ser  Ser Gly Pro 
    1190                 1195                 1200             


Thr Asn  Val Ser Ala Leu Ala  Thr Thr Ser Ser Ser  Met Leu Val 
    1205                 1210                 1215             


Arg Trp  Ser Glu Val Pro Glu  Ala Asp Arg Asn Gly  Leu Val Leu 
    1220                 1225                 1230             


Gly Tyr  Lys Val Met Tyr Lys  Glu Lys Asp Ser Asp  Thr Gln Pro 
    1235                 1240                 1245             


Arg Phe  Trp Leu Val Glu Gly  Asn Ser Ser Arg Ser  Ala Gln Leu 
    1250                 1255                 1260             


Thr Gly  Leu Gly Lys Tyr Val  Leu Tyr Glu Val Gln  Val Leu Ala 
    1265                 1270                 1275             


Phe Thr  Arg Ile Gly Asp Gly  Ser Pro Ser His Pro  Pro Ile Leu 
    1280                 1285                 1290             


Glu Arg  Thr Leu Asp Asp Val  Pro Gly Pro Pro Met  Gly Ile Leu 
    1295                 1300                 1305             


Phe Pro  Glu Val Arg Thr Thr  Ser Val Arg Leu Ile  Trp Gln Pro 
    1310                 1315                 1320             


Pro Ala  Ala Pro Asn Gly Ile  Ile Leu Ala Tyr Gln  Ile Thr His 
    1325                 1330                 1335             


Arg Leu  Asn Thr Thr Thr Ala  Asn Thr Ala Thr Val  Glu Val Leu 
    1340                 1345                 1350             


Ala Pro  Ser Ala Arg Gln Tyr  Thr Ala Thr Gly Leu  Lys Pro Glu 
    1355                 1360                 1365             


Ser Val  Tyr Leu Phe Arg Ile  Thr Ala Gln Thr Arg  Lys Gly Trp 
    1370                 1375                 1380             


Gly Glu  Ala Ala Glu Ala Leu  Val Val Thr Thr Glu  Lys Arg Asp 
    1385                 1390                 1395             


Arg Pro  Gln Pro Pro Ser Arg  Pro Met Val Gln Gln  Glu Asp Val 
    1400                 1405                 1410             


Arg Ala  Arg Ser Val Leu Leu  Ser Trp Glu Pro Gly  Ser Asp Gly 
    1415                 1420                 1425             


Leu Ser  Pro Val Arg Tyr Tyr  Thr Ile Gln Thr Arg  Glu Leu Pro 
    1430                 1435                 1440             


Ser Gly  Arg Trp Ala Leu His  Ser Ala Ser Val Ser  His Asn Ala 
    1445                 1450                 1455             


Ser Ser  Phe Ile Val Asp Arg  Leu Lys Pro Phe Thr  Ser Tyr Lys 
    1460                 1465                 1470             


Phe Arg  Val Lys Ala Thr Asn  Asp Ile Gly Asp Ser  Glu Phe Ser 
    1475                 1480                 1485             


Glu Glu  Ser Glu Ser Leu Thr  Thr Leu Gln Ala Ala  Pro Asp Glu 
    1490                 1495                 1500             


Ala Pro  Thr Ile Leu Ser Val  Thr Pro His Thr Thr  Thr Ser Val 
    1505                 1510                 1515             


Leu Ile  Arg Trp Gln Pro Pro  Ala Glu Asp Lys Ile  Asn Gly Ile 
    1520                 1525                 1530             


Leu Leu  Gly Phe Arg Ile Arg  Tyr Arg Glu Leu Leu  Tyr Glu Gly 
    1535                 1540                 1545             


Leu Arg  Gly Phe Thr Leu Arg  Gly Ile Asn Asn Pro  Gly Ala Thr 
    1550                 1555                 1560             


Trp Ala  Glu Leu Thr Ser Met  Tyr Ser Met Arg Asn  Leu Ser Arg 
    1565                 1570                 1575             


Pro Ser  Leu Thr Gln Tyr Glu  Leu Asp Asn Leu Asn  Lys His Arg 
    1580                 1585                 1590             


Arg Tyr  Glu Ile Arg Met Ser  Val Tyr Asn Ala Val  Gly Glu Gly 
    1595                 1600                 1605             


Pro Ser  Ser Pro Pro Gln Glu  Val Phe Val Gly Glu  Ala Val Pro 
    1610                 1615                 1620             


Thr Ala  Ala Pro Arg Asn Val  Val Val His Gly Ala  Thr Ala Thr 
    1625                 1630                 1635             


Gln Leu  Asp Val Thr Trp Glu  Pro Pro Pro Leu Asp  Ser Gln Asn 
    1640                 1645                 1650             


Gly Asp  Ile Gln Gly Tyr Lys  Ile Tyr Phe Trp Glu  Ala Gln Arg 
    1655                 1660                 1665             


Gly Asn  Leu Thr Glu Arg Val  Lys Thr Leu Phe Leu  Ala Glu Asn 
    1670                 1675                 1680             


Ser Val  Lys Leu Lys Asn Leu  Thr Gly Tyr Thr Ala  Tyr Met Val 
    1685                 1690                 1695             


Ser Val  Ala Ala Phe Asn Ala  Ala Gly Asp Gly Pro  Arg Ser Thr 
    1700                 1705                 1710             


Pro Thr  Gln Gly Gln Thr Gln  Gln Ala Ala Pro Ser  Ala Pro Ser 
    1715                 1720                 1725             


Ser Val  Lys Phe Ser Glu Leu  Thr Thr Thr Ser Val  Asn Val Ser 
    1730                 1735                 1740             


Trp Glu  Ala Pro Gln Phe Pro  Asn Gly Ile Leu Glu  Gly Tyr Arg 
    1745                 1750                 1755             


Leu Val  Tyr Glu Pro Cys Ser  Pro Val Asp Gly Val  Ser Lys Ile 
    1760                 1765                 1770             


Val Thr  Val Asp Val Lys Gly  Asn Ser Pro Leu Trp  Leu Lys Val 
    1775                 1780                 1785             


Lys Asp  Leu Ala Glu Gly Val  Thr Tyr Arg Phe Arg  Ile Arg Ala 
    1790                 1795                 1800             


Lys Thr  Phe Thr Tyr Gly Pro  Glu Ile Glu Ala Asn  Val Thr Thr 
    1805                 1810                 1815             


Gly Pro  Gly Glu Gly Ala Pro  Gly Pro Pro Gly Val  Pro Ile Ile 
    1820                 1825                 1830             


Val Arg  Tyr Ser Ser Ala Ile  Ala Ile His Trp Ser  Ser Gly Asp 
    1835                 1840                 1845             


Pro Gly  Lys Gly Pro Ile Thr  Arg Tyr Val Ile Glu  Ala Arg Pro 
    1850                 1855                 1860             


Ser Asp  Glu Gly Leu Trp Asp  Ile Leu Ile Lys Asp  Ile Pro Lys 
    1865                 1870                 1875             


Glu Val  Ser Ser Tyr Thr Phe  Ser Met Asp Ile Leu  Lys Pro Gly 
    1880                 1885                 1890             


Val Ser  Tyr Asp Phe Arg Val  Ile Ala Val Asn Asp  Tyr Gly Phe 
    1895                 1900                 1905             


Gly Thr  Pro Ser Ser Pro Ser  Gln Ser Val Pro Ala  Gln Lys Ala 
    1910                 1915                 1920             


Asn Pro  Phe Tyr Glu Glu Trp  Trp Phe Leu Val Val  Ile Ala Leu 
    1925                 1930                 1935             


Val Gly  Leu Ile Phe Ile Leu  Leu Leu Val Phe Val  Leu Ile Ile 
    1940                 1945                 1950             


Arg Gly  Gln Ser Lys Lys Tyr  Ala Lys Lys Thr Asp  Ser Gly Asn 
    1955                 1960                 1965             


Ser Ala  Lys Ser Gly Ala Leu  Gly His Ser Glu Met  Met Ser Leu 
    1970                 1975                 1980             


Asp Glu  Ser Ser Phe Pro Ala  Leu Glu Leu Asn Asn  Arg Arg Leu 
    1985                 1990                 1995             


Ser Val  Lys Asn Ser Phe Cys  Arg Lys Asn Gly Leu  Tyr Thr Arg 
    2000                 2005                 2010             


Ser Pro  Pro Arg Pro Ser Pro  Gly Ser Leu His Tyr  Ser Asp Glu 
    2015                 2020                 2025             


Asp Val  Thr Lys Tyr Asn Asp  Leu Ile Pro Ala Glu  Ser Ser Ser 
    2030                 2035                 2040             


Leu Thr  Glu Lys Pro Ser Glu  Ile Ser Asp Ser Gln  Gly Ser Asp 
    2045                 2050                 2055             


Ser Glu  Tyr Glu Val Asp Ser  Asn His Gln Lys Ala  His Ser Phe 
    2060                 2065                 2070             


Val Asn  His Tyr Ile Ser Asp  Pro Thr Tyr Tyr Asn  Ser Trp Arg 
    2075                 2080                 2085             


Arg Gln  Gln Lys Gly Ile Ser  Arg Ala Gln Ala Tyr  Ser Tyr Thr 
    2090                 2095                 2100             


Glu Ser  Asp Ser Gly Glu Pro  Asp His Thr Thr Val  Thr Asn Ser 
    2105                 2110                 2115             


Thr Ser  Thr Gln Gln Gly Ser  Leu Phe Arg Pro Lys  Ala Ser Arg 
    2120                 2125                 2130             


Thr Pro  Thr Pro Gln Asn Pro  Pro Asn Pro Pro Ser  Gln Gln Ser 
    2135                 2140                 2145             


Thr Leu  Tyr Arg Pro Pro Ser  Ser Leu Ala Pro Gly  Ser Arg Ala 
    2150                 2155                 2160             


Pro Ile  Ala Gly Phe Ser Ser  Phe Val 
    2165                 2170         


<210>  1800
<211>  1141
<212>  PRT
<213>  Homo sapiens

<400>  1800

Met Ala Gly Ala Arg Ser Arg Asp Pro Trp Gly Ala Ser Gly Ile Cys 
1               5                   10                  15      


Tyr Leu Phe Gly Ser Leu Leu Val Glu Leu Leu Phe Ser Arg Ala Val 
            20                  25                  30          


Ala Phe Asn Leu Asp Val Met Gly Ala Leu Arg Lys Glu Gly Glu Pro 
        35                  40                  45              


Gly Ser Leu Phe Gly Phe Ser Val Ala Leu His Arg Gln Leu Gln Pro 
    50                  55                  60                  


Arg Pro Gln Ser Trp Leu Leu Val Gly Ala Pro Gln Ala Leu Ala Leu 
65                  70                  75                  80  


Pro Gly Gln Gln Ala Asn Arg Thr Gly Gly Leu Phe Ala Cys Pro Leu 
                85                  90                  95      


Ser Leu Glu Glu Thr Asp Cys Tyr Arg Val Asp Ile Asp Gln Gly Ala 
            100                 105                 110         


Asp Met Gln Lys Glu Ser Lys Glu Asn Gln Trp Leu Gly Val Ser Val 
        115                 120                 125             


Arg Ser Gln Gly Pro Gly Gly Lys Ile Val Thr Cys Ala His Arg Tyr 
    130                 135                 140                 


Glu Ala Arg Gln Arg Val Asp Gln Ile Leu Glu Thr Arg Asp Met Ile 
145                 150                 155                 160 


Gly Arg Cys Phe Val Leu Ser Gln Asp Leu Ala Ile Arg Asp Glu Leu 
                165                 170                 175     


Asp Gly Gly Glu Trp Lys Phe Cys Glu Gly Arg Pro Gln Gly His Glu 
            180                 185                 190         


Gln Phe Gly Phe Cys Gln Gln Gly Thr Ala Ala Ala Phe Ser Pro Asp 
        195                 200                 205             


Ser His Tyr Leu Leu Phe Gly Ala Pro Gly Thr Tyr Asn Trp Lys Gly 
    210                 215                 220                 


Thr Ala Arg Val Glu Leu Cys Ala Gln Gly Ser Ala Asp Leu Ala His 
225                 230                 235                 240 


Leu Asp Asp Gly Pro Tyr Glu Ala Gly Gly Glu Lys Glu Gln Asp Pro 
                245                 250                 255     


Arg Leu Ile Pro Val Pro Ala Asn Ser Tyr Phe Gly Phe Ser Ile Asp 
            260                 265                 270         


Ser Gly Lys Gly Leu Val Arg Ala Glu Glu Leu Ser Phe Val Ala Gly 
        275                 280                 285             


Ala Pro Arg Ala Asn His Lys Gly Ala Val Val Ile Leu Arg Lys Asp 
    290                 295                 300                 


Ser Ala Ser Arg Leu Val Pro Glu Val Met Leu Ser Gly Glu Arg Leu 
305                 310                 315                 320 


Thr Ser Gly Phe Gly Tyr Ser Leu Ala Val Ala Asp Leu Asn Ser Asp 
                325                 330                 335     


Gly Trp Pro Asp Leu Ile Val Gly Ala Pro Tyr Phe Phe Glu Arg Gln 
            340                 345                 350         


Glu Glu Leu Gly Gly Ala Val Tyr Val Tyr Leu Asn Gln Gly Gly His 
        355                 360                 365             


Trp Ala Gly Ile Ser Pro Leu Arg Leu Cys Gly Ser Pro Asp Ser Met 
    370                 375                 380                 


Phe Gly Ile Ser Leu Ala Val Leu Gly Asp Leu Asn Gln Asp Gly Phe 
385                 390                 395                 400 


Pro Asp Ile Ala Val Gly Ala Pro Phe Asp Gly Asp Gly Lys Val Phe 
                405                 410                 415     


Ile Tyr His Gly Ser Ser Leu Gly Val Val Ala Lys Pro Ser Gln Val 
            420                 425                 430         


Leu Glu Gly Glu Ala Val Gly Ile Lys Ser Phe Gly Tyr Ser Leu Ser 
        435                 440                 445             


Gly Ser Leu Asp Met Asp Gly Asn Gln Tyr Pro Asp Leu Leu Val Gly 
    450                 455                 460                 


Ser Leu Ala Asp Thr Ala Val Leu Phe Arg Ala Arg Pro Ile Leu His 
465                 470                 475                 480 


Val Ser His Glu Val Ser Ile Ala Pro Arg Ser Ile Asp Leu Glu Gln 
                485                 490                 495     


Pro Asn Cys Ala Gly Gly His Ser Val Cys Val Asp Leu Arg Val Cys 
            500                 505                 510         


Phe Ser Tyr Ile Ala Val Pro Ser Ser Tyr Ser Pro Thr Val Ala Leu 
        515                 520                 525             


Asp Tyr Val Leu Asp Ala Asp Thr Asp Arg Arg Leu Arg Gly Gln Val 
    530                 535                 540                 


Pro Arg Val Thr Phe Leu Ser Arg Asn Leu Glu Glu Pro Lys His Gln 
545                 550                 555                 560 


Ala Ser Gly Thr Val Trp Leu Lys His Gln His Asp Arg Val Cys Gly 
                565                 570                 575     


Asp Ala Met Phe Gln Leu Gln Glu Asn Val Lys Asp Lys Leu Arg Ala 
            580                 585                 590         


Ile Val Val Thr Leu Ser Tyr Ser Leu Gln Thr Pro Arg Leu Arg Arg 
        595                 600                 605             


Gln Ala Pro Gly Gln Gly Leu Pro Pro Val Ala Pro Ile Leu Asn Ala 
    610                 615                 620                 


His Gln Pro Ser Thr Gln Arg Ala Glu Ile His Phe Leu Lys Gln Gly 
625                 630                 635                 640 


Cys Gly Glu Asp Lys Ile Cys Gln Ser Asn Leu Gln Leu Val Arg Ala 
                645                 650                 655     


Arg Phe Cys Thr Arg Val Ser Asp Thr Glu Phe Gln Pro Leu Pro Met 
            660                 665                 670         


Asp Val Asp Gly Thr Thr Ala Leu Phe Ala Leu Ser Gly Gln Pro Val 
        675                 680                 685             


Ile Gly Leu Glu Leu Met Val Thr Asn Leu Pro Ser Asp Pro Ala Gln 
    690                 695                 700                 


Pro Gln Ala Asp Gly Asp Asp Ala His Glu Ala Gln Leu Leu Val Met 
705                 710                 715                 720 


Leu Pro Asp Ser Leu His Tyr Ser Gly Val Arg Ala Leu Asp Pro Ala 
                725                 730                 735     


Glu Lys Pro Leu Cys Leu Ser Asn Glu Asn Ala Ser His Val Glu Cys 
            740                 745                 750         


Glu Leu Gly Asn Pro Met Lys Arg Gly Ala Gln Val Thr Phe Tyr Leu 
        755                 760                 765             


Ile Leu Ser Thr Ser Gly Ile Ser Ile Glu Thr Thr Glu Leu Glu Val 
    770                 775                 780                 


Glu Leu Leu Leu Ala Thr Ile Ser Glu Gln Glu Leu His Pro Val Ser 
785                 790                 795                 800 


Ala Arg Ala Arg Val Phe Ile Glu Leu Pro Leu Ser Ile Ala Gly Met 
                805                 810                 815     


Ala Ile Pro Gln Gln Leu Phe Phe Ser Gly Val Val Arg Gly Glu Arg 
            820                 825                 830         


Ala Met Gln Ser Glu Arg Asp Val Gly Ser Lys Val Lys Tyr Glu Val 
        835                 840                 845             


Thr Val Ser Asn Gln Gly Gln Ser Leu Arg Thr Leu Gly Ser Ala Phe 
    850                 855                 860                 


Leu Asn Ile Met Trp Pro His Glu Ile Ala Asn Gly Lys Trp Leu Leu 
865                 870                 875                 880 


Tyr Pro Met Gln Val Glu Leu Glu Gly Gly Gln Gly Pro Gly Gln Lys 
                885                 890                 895     


Gly Leu Cys Ser Pro Arg Pro Asn Ile Leu His Leu Asp Val Asp Ser 
            900                 905                 910         


Arg Asp Arg Arg Arg Arg Glu Leu Glu Pro Pro Glu Gln Gln Glu Pro 
        915                 920                 925             


Gly Glu Arg Gln Glu Pro Ser Met Ser Trp Trp Pro Val Ser Ser Ala 
    930                 935                 940                 


Glu Lys Lys Lys Asn Ile Thr Leu Asp Cys Ala Arg Gly Thr Ala Asn 
945                 950                 955                 960 


Cys Val Val Phe Ser Cys Pro Leu Tyr Ser Phe Asp Arg Ala Ala Val 
                965                 970                 975     


Leu His Val Trp Gly Arg Leu Trp Asn Ser Thr Phe Leu Glu Glu Tyr 
            980                 985                 990         


Ser Ala Val Lys Ser Leu Glu Val  Ile Val Arg Ala Asn  Ile Thr Val 
        995                 1000                 1005             


Lys Ser  Ser Ile Lys Asn Leu  Met Leu Arg Asp Ala  Ser Thr Val 
    1010                 1015                 1020             


Ile Pro  Val Met Val Tyr Leu  Asp Pro Met Ala Val  Val Ala Glu 
    1025                 1030                 1035             


Gly Val  Pro Trp Trp Val Ile  Leu Leu Ala Val Leu  Ala Gly Leu 
    1040                 1045                 1050             


Leu Val  Leu Ala Leu Leu Val  Leu Leu Leu Trp Lys  Met Gly Phe 
    1055                 1060                 1065             


Phe Lys  Arg Ala Lys His Pro  Glu Ala Thr Val Pro  Gln Tyr His 
    1070                 1075                 1080             


Ala Val  Lys Ile Pro Arg Glu  Asp Arg Gln Gln Phe  Lys Glu Glu 
    1085                 1090                 1095             


Lys Thr  Gly Thr Ile Leu Arg  Asn Asn Trp Gly Ser  Pro Arg Arg 
    1100                 1105                 1110             


Glu Gly  Pro Asp Ala His Pro  Ile Leu Ala Ala Asp  Gly His Pro 
    1115                 1120                 1125             


Glu Leu  Gly Pro Asp Gly His  Pro Gly Pro Gly Thr  Ala 
    1130                 1135                 1140     


<210>  1801
<211>  1044
<212>  PRT
<213>  Homo sapiens

<400>  1801

Met Ala Pro Phe Ala Thr Pro Met Val Gln Ala Leu Thr Thr Thr Arg 
1               5                   10                  15      


Ile Gln Arg Gln Ala Glu Gly Phe Gln Cys Trp Arg Glu Cys Gly Thr 
            20                  25                  30          


Arg Arg Ser Pro Phe Glu Gly Lys Glu Thr Cys Ala His Arg Tyr Glu 
        35                  40                  45              


Ala Arg Gln Arg Val Asp Gln Ile Leu Glu Thr Arg Asp Met Ile Gly 
    50                  55                  60                  


Arg Cys Phe Val Leu Ser Gln Asp Leu Ala Ile Arg Asp Glu Leu Asp 
65                  70                  75                  80  


Gly Gly Glu Trp Lys Phe Cys Glu Gly Arg Pro Gln Gly His Glu Gln 
                85                  90                  95      


Phe Gly Phe Cys Gln Gln Gly Thr Ala Ala Ala Phe Ser Pro Asp Ser 
            100                 105                 110         


His Tyr Leu Leu Phe Gly Ala Pro Gly Thr Tyr Asn Trp Lys Gly Thr 
        115                 120                 125             


Ala Arg Val Glu Leu Cys Ala Gln Gly Ser Ala Asp Leu Ala His Leu 
    130                 135                 140                 


Asp Asp Gly Pro Tyr Glu Ala Gly Gly Glu Lys Glu Gln Asp Pro Arg 
145                 150                 155                 160 


Leu Ile Pro Val Pro Ala Asn Ser Tyr Phe Gly Phe Ser Ile Asp Ser 
                165                 170                 175     


Gly Lys Gly Leu Val Arg Ala Glu Glu Leu Ser Phe Val Ala Gly Ala 
            180                 185                 190         


Pro Arg Ala Asn His Lys Gly Ala Val Val Ile Leu Arg Lys Asp Ser 
        195                 200                 205             


Ala Ser Arg Leu Val Pro Glu Val Met Leu Ser Gly Glu Arg Leu Thr 
    210                 215                 220                 


Ser Gly Phe Gly Tyr Ser Leu Ala Val Ala Asp Leu Asn Ser Asp Gly 
225                 230                 235                 240 


Trp Pro Asp Leu Ile Val Gly Ala Pro Tyr Phe Phe Glu Arg Gln Glu 
                245                 250                 255     


Glu Leu Gly Gly Ala Val Tyr Val Tyr Leu Asn Gln Gly Gly His Trp 
            260                 265                 270         


Ala Gly Ile Ser Pro Leu Arg Leu Cys Gly Ser Pro Asp Ser Met Phe 
        275                 280                 285             


Gly Ile Ser Leu Ala Val Leu Gly Asp Leu Asn Gln Asp Gly Phe Pro 
    290                 295                 300                 


Asp Ile Ala Val Gly Ala Pro Phe Asp Gly Asp Gly Lys Val Phe Ile 
305                 310                 315                 320 


Tyr His Gly Ser Ser Leu Gly Val Val Ala Lys Pro Ser Gln Val Leu 
                325                 330                 335     


Glu Gly Glu Ala Val Gly Ile Lys Ser Phe Gly Tyr Ser Leu Ser Gly 
            340                 345                 350         


Ser Leu Asp Met Asp Gly Asn Gln Tyr Pro Asp Leu Leu Val Gly Ser 
        355                 360                 365             


Leu Ala Asp Thr Ala Val Leu Phe Arg Ala Arg Pro Ile Leu His Val 
    370                 375                 380                 


Ser His Glu Val Ser Ile Ala Pro Arg Ser Ile Asp Leu Glu Gln Pro 
385                 390                 395                 400 


Asn Cys Ala Gly Gly His Ser Val Cys Val Asp Leu Arg Val Cys Phe 
                405                 410                 415     


Ser Tyr Ile Ala Val Pro Ser Ser Tyr Ser Pro Thr Val Ala Leu Asp 
            420                 425                 430         


Tyr Val Leu Asp Ala Asp Thr Asp Arg Arg Leu Arg Gly Gln Val Pro 
        435                 440                 445             


Arg Val Thr Phe Leu Ser Arg Asn Leu Glu Glu Pro Lys His Gln Ala 
    450                 455                 460                 


Ser Gly Thr Val Trp Leu Lys His Gln His Asp Arg Val Cys Gly Asp 
465                 470                 475                 480 


Ala Met Phe Gln Leu Gln Glu Asn Val Lys Asp Lys Leu Arg Ala Ile 
                485                 490                 495     


Val Val Thr Leu Ser Tyr Ser Leu Gln Thr Pro Arg Leu Arg Arg Gln 
            500                 505                 510         


Ala Pro Gly Gln Gly Leu Pro Pro Val Ala Pro Ile Leu Asn Ala His 
        515                 520                 525             


Gln Pro Ser Thr Gln Arg Ala Glu Ile His Phe Leu Lys Gln Gly Cys 
    530                 535                 540                 


Gly Glu Asp Lys Ile Cys Gln Ser Asn Leu Gln Leu Val Arg Ala Arg 
545                 550                 555                 560 


Phe Cys Thr Arg Val Ser Asp Thr Glu Phe Gln Pro Leu Pro Met Asp 
                565                 570                 575     


Val Asp Gly Thr Thr Ala Leu Phe Ala Leu Ser Gly Gln Pro Val Ile 
            580                 585                 590         


Gly Leu Glu Leu Met Val Thr Asn Leu Pro Ser Asp Pro Ala Gln Pro 
        595                 600                 605             


Gln Ala Asp Gly Asp Asp Ala His Glu Ala Gln Leu Leu Val Met Leu 
    610                 615                 620                 


Pro Asp Ser Leu His Tyr Ser Gly Val Arg Ala Leu Asp Pro Ala Glu 
625                 630                 635                 640 


Lys Pro Leu Cys Leu Ser Asn Glu Asn Ala Ser His Val Glu Cys Glu 
                645                 650                 655     


Leu Gly Asn Pro Met Lys Arg Gly Ala Gln Val Thr Phe Tyr Leu Ile 
            660                 665                 670         


Leu Ser Thr Ser Gly Ile Ser Ile Glu Thr Thr Glu Leu Glu Val Glu 
        675                 680                 685             


Leu Leu Leu Ala Thr Ile Ser Glu Gln Glu Leu His Pro Val Ser Ala 
    690                 695                 700                 


Arg Ala Arg Val Phe Ile Glu Leu Pro Leu Ser Ile Ala Gly Met Ala 
705                 710                 715                 720 


Ile Pro Gln Gln Leu Phe Phe Ser Gly Val Val Arg Gly Glu Arg Ala 
                725                 730                 735     


Met Gln Ser Glu Arg Asp Val Gly Ser Lys Val Lys Tyr Glu Val Thr 
            740                 745                 750         


Val Ser Asn Gln Gly Gln Ser Leu Arg Thr Leu Gly Ser Ala Phe Leu 
        755                 760                 765             


Asn Ile Met Trp Pro His Glu Ile Ala Asn Gly Lys Trp Leu Leu Tyr 
    770                 775                 780                 


Pro Met Gln Val Glu Leu Glu Gly Gly Gln Gly Pro Gly Gln Lys Gly 
785                 790                 795                 800 


Leu Cys Ser Pro Arg Pro Asn Ile Leu His Leu Asp Val Asp Ser Arg 
                805                 810                 815     


Asp Arg Arg Arg Arg Glu Leu Glu Pro Pro Glu Gln Gln Glu Pro Gly 
            820                 825                 830         


Glu Arg Gln Glu Pro Ser Met Ser Trp Trp Pro Val Ser Ser Ala Glu 
        835                 840                 845             


Lys Lys Lys Asn Ile Thr Leu Asp Cys Ala Arg Gly Thr Ala Asn Cys 
    850                 855                 860                 


Val Val Phe Ser Cys Pro Leu Tyr Ser Phe Asp Arg Ala Ala Val Leu 
865                 870                 875                 880 


His Val Trp Gly Arg Leu Trp Asn Ser Thr Phe Leu Glu Glu Tyr Ser 
                885                 890                 895     


Ala Val Lys Ser Leu Glu Val Ile Val Arg Ala Asn Ile Thr Val Lys 
            900                 905                 910         


Ser Ser Ile Lys Asn Leu Met Leu Arg Asp Ala Ser Thr Val Ile Pro 
        915                 920                 925             


Val Met Val Tyr Leu Asp Pro Met Ala Val Val Ala Glu Gly Val Pro 
    930                 935                 940                 


Trp Trp Val Ile Leu Leu Ala Val Leu Ala Gly Leu Leu Val Leu Ala 
945                 950                 955                 960 


Leu Leu Val Leu Leu Leu Trp Lys Met Gly Phe Phe Lys Arg Ala Lys 
                965                 970                 975     


His Pro Glu Ala Thr Val Pro Gln Tyr His Ala Val Lys Ile Pro Arg 
            980                 985                 990         


Glu Asp Arg Gln Gln Phe Lys Glu  Glu Lys Thr Gly Thr  Ile Leu Arg 
        995                 1000                 1005             


Asn Asn  Trp Gly Ser Pro Arg  Arg Glu Gly Pro Asp  Ala His Pro 
    1010                 1015                 1020             


Ile Leu  Ala Ala Asp Gly His  Pro Glu Leu Gly Pro  Asp Gly His 
    1025                 1030                 1035             


Pro Gly  Pro Gly Thr Ala 
    1040                 


<210>  1802
<211>  1002
<212>  PRT
<213>  Homo sapiens

<400>  1802

Met Leu Leu Gly Thr Leu Leu Leu Ile Leu Tyr Ile Leu Met Leu Cys 
1               5                   10                  15      


Arg Met Phe Leu Leu Val Gly Ala Pro Lys Ala Asn Thr Thr Gln Pro 
            20                  25                  30          


Gly Ile Val Glu Gly Gly Gln Val Leu Lys Cys Asp Trp Ser Ser Thr 
        35                  40                  45              


Arg Arg Cys Gln Pro Ile Glu Phe Asp Ala Thr Gly Asn Arg Asp Tyr 
    50                  55                  60                  


Ala Lys Asp Asp Pro Leu Glu Phe Lys Ser His Gln Trp Phe Gly Ala 
65                  70                  75                  80  


Ser Val Arg Ser Lys Gln Asp Lys Ile Leu Ala Cys Ala Pro Leu Tyr 
                85                  90                  95      


His Trp Arg Thr Glu Met Lys Gln Glu Arg Glu Pro Val Gly Thr Cys 
            100                 105                 110         


Phe Leu Gln Asp Gly Thr Lys Thr Val Glu Tyr Ala Pro Cys Arg Ser 
        115                 120                 125             


Gln Asp Ile Asp Ala Asp Gly Gln Gly Phe Cys Gln Gly Gly Phe Ser 
    130                 135                 140                 


Ile Asp Phe Thr Lys Ala Asp Arg Val Leu Leu Gly Gly Pro Gly Ser 
145                 150                 155                 160 


Phe Tyr Trp Gln Gly Gln Leu Ile Ser Asp Gln Val Ala Glu Ile Val 
                165                 170                 175     


Ser Lys Tyr Asp Pro Asn Val Tyr Ser Ile Lys Tyr Asn Asn Gln Leu 
            180                 185                 190         


Ala Thr Arg Thr Ala Gln Ala Ile Phe Asp Asp Ser Tyr Leu Gly Tyr 
        195                 200                 205             


Ser Val Ala Val Gly Asp Phe Asn Gly Asp Gly Ile Asp Asp Phe Val 
    210                 215                 220                 


Ser Gly Val Pro Arg Ala Ala Arg Thr Leu Gly Met Val Tyr Ile Tyr 
225                 230                 235                 240 


Asp Gly Lys Asn Met Ser Ser Leu Tyr Asn Phe Thr Gly Glu Gln Met 
                245                 250                 255     


Ala Ala Tyr Phe Gly Phe Ser Val Ala Ala Thr Asp Ile Asn Gly Asp 
            260                 265                 270         


Asp Tyr Ala Asp Val Phe Ile Gly Ala Pro Leu Phe Met Asp Arg Gly 
        275                 280                 285             


Ser Asp Gly Lys Leu Gln Glu Val Gly Gln Val Ser Val Ser Leu Gln 
    290                 295                 300                 


Arg Ala Ser Gly Asp Phe Gln Thr Thr Lys Leu Asn Gly Phe Glu Val 
305                 310                 315                 320 


Phe Ala Arg Phe Gly Ser Ala Ile Ala Pro Leu Gly Asp Leu Asp Gln 
                325                 330                 335     


Asp Gly Phe Asn Asp Ile Ala Ile Ala Ala Pro Tyr Gly Gly Glu Asp 
            340                 345                 350         


Lys Lys Gly Ile Val Tyr Ile Phe Asn Gly Arg Ser Thr Gly Leu Asn 
        355                 360                 365             


Ala Val Pro Ser Gln Ile Leu Glu Gly Gln Trp Ala Ala Arg Ser Met 
    370                 375                 380                 


Pro Pro Ser Phe Gly Tyr Ser Met Lys Gly Ala Thr Asp Ile Asp Lys 
385                 390                 395                 400 


Asn Gly Tyr Pro Asp Leu Ile Val Gly Ala Phe Gly Val Asp Arg Ala 
                405                 410                 415     


Ile Leu Tyr Arg Ala Arg Pro Val Ile Thr Val Asn Ala Gly Leu Glu 
            420                 425                 430         


Val Tyr Pro Ser Ile Leu Asn Gln Asp Asn Lys Thr Cys Ser Leu Pro 
        435                 440                 445             


Gly Thr Ala Leu Lys Val Ser Cys Phe Asn Val Arg Phe Cys Leu Lys 
    450                 455                 460                 


Ala Asp Gly Lys Gly Val Leu Pro Arg Lys Leu Asn Phe Gln Val Glu 
465                 470                 475                 480 


Leu Leu Leu Asp Lys Leu Lys Gln Lys Gly Ala Ile Arg Arg Ala Leu 
                485                 490                 495     


Phe Leu Tyr Ser Arg Ser Pro Ser His Ser Lys Asn Met Thr Ile Ser 
            500                 505                 510         


Arg Gly Gly Leu Met Gln Cys Glu Glu Leu Ile Ala Tyr Leu Arg Asp 
        515                 520                 525             


Glu Ser Glu Phe Arg Asp Lys Leu Thr Pro Ile Thr Ile Phe Met Glu 
    530                 535                 540                 


Tyr Arg Leu Asp Tyr Arg Thr Ala Ala Asp Thr Thr Gly Leu Gln Pro 
545                 550                 555                 560 


Ile Leu Asn Gln Phe Thr Pro Ala Asn Ile Ser Arg Gln Ala His Ile 
                565                 570                 575     


Leu Leu Asp Cys Gly Glu Asp Asn Val Cys Lys Pro Lys Leu Glu Val 
            580                 585                 590         


Ser Val Asp Ser Asp Gln Lys Lys Ile Tyr Ile Gly Asp Asp Asn Pro 
        595                 600                 605             


Leu Thr Leu Ile Val Lys Ala Gln Asn Gln Gly Glu Gly Ala Tyr Glu 
    610                 615                 620                 


Ala Glu Leu Ile Val Ser Ile Pro Leu Gln Ala Asp Phe Ile Gly Val 
625                 630                 635                 640 


Val Arg Asn Asn Glu Ala Leu Ala Arg Leu Ser Cys Ala Phe Lys Thr 
                645                 650                 655     


Glu Asn Gln Thr Arg Gln Val Val Cys Asp Leu Gly Asn Pro Met Lys 
            660                 665                 670         


Ala Gly Thr Gln Leu Leu Ala Gly Leu Arg Phe Ser Val His Gln Gln 
        675                 680                 685             


Ser Glu Met Asp Thr Ser Val Lys Phe Asp Leu Gln Ile Gln Ser Ser 
    690                 695                 700                 


Asn Leu Phe Asp Lys Val Ser Pro Val Val Ser His Lys Val Asp Leu 
705                 710                 715                 720 


Ala Val Leu Ala Ala Val Glu Ile Arg Gly Val Ser Ser Pro Asp His 
                725                 730                 735     


Ile Phe Leu Pro Ile Pro Asn Trp Glu His Lys Glu Asn Pro Glu Thr 
            740                 745                 750         


Glu Glu Asp Val Gly Pro Val Val Gln His Ile Tyr Glu Leu Arg Asn 
        755                 760                 765             


Asn Gly Pro Ser Ser Phe Ser Lys Ala Met Leu His Leu Gln Trp Pro 
    770                 775                 780                 


Tyr Lys Tyr Asn Asn Asn Thr Leu Leu Tyr Ile Leu His Tyr Asp Ile 
785                 790                 795                 800 


Asp Gly Pro Met Asn Cys Thr Ser Asp Met Glu Ile Asn Pro Leu Arg 
                805                 810                 815     


Ile Lys Ile Ser Ser Leu Gln Thr Thr Glu Lys Asn Asp Thr Val Ala 
            820                 825                 830         


Gly Gln Gly Glu Arg Asp His Leu Ile Thr Lys Arg Asp Leu Ala Leu 
        835                 840                 845             


Ser Glu Gly Asp Ile His Thr Leu Gly Cys Gly Val Ala Gln Cys Leu 
    850                 855                 860                 


Lys Ile Val Cys Gln Val Gly Arg Leu Asp Arg Gly Lys Ser Ala Ile 
865                 870                 875                 880 


Leu Tyr Val Lys Ser Leu Leu Trp Thr Glu Thr Phe Met Asn Lys Glu 
                885                 890                 895     


Asn Gln Asn His Ser Tyr Ser Leu Lys Ser Ser Ala Ser Phe Asn Val 
            900                 905                 910         


Ile Glu Phe Pro Tyr Lys Asn Leu Pro Ile Glu Asp Ile Thr Asn Ser 
        915                 920                 925             


Thr Leu Val Thr Thr Asn Val Thr Trp Gly Ile Gln Pro Ala Pro Met 
    930                 935                 940                 


Pro Val Pro Val Trp Val Ile Ile Leu Ala Val Leu Ala Gly Leu Leu 
945                 950                 955                 960 


Leu Leu Ala Val Leu Val Phe Val Met Tyr Arg Met Gly Phe Phe Lys 
                965                 970                 975     


Arg Val Arg Pro Pro Gln Glu Glu Gln Glu Arg Glu Gln Leu Gln Pro 
            980                 985                 990         


His Glu Asn Gly Glu Gly Asn Ser  Glu Thr 
        995                 1000         


<210>  1803
<211>  1012
<212>  PRT
<213>  Homo sapiens

<400>  1803

Met Ala Phe Pro Pro Arg Arg Arg Leu Arg Leu Gly Pro Arg Gly Leu 
1               5                   10                  15      


Pro Leu Leu Leu Ser Gly Leu Leu Leu Pro Leu Cys Arg Ala Phe Asn 
            20                  25                  30          


Leu Asp Val Asp Ser Pro Ala Glu Tyr Ser Gly Pro Glu Gly Ser Tyr 
        35                  40                  45              


Phe Gly Phe Ala Val Asp Phe Phe Val Pro Ser Ala Ser Ser Arg Met 
    50                  55                  60                  


Phe Leu Leu Val Gly Ala Pro Lys Ala Asn Thr Thr Gln Pro Gly Ile 
65                  70                  75                  80  


Val Glu Gly Gly Gln Val Leu Lys Cys Asp Trp Ser Ser Thr Arg Arg 
                85                  90                  95      


Cys Gln Pro Ile Glu Phe Asp Ala Thr Gly Asn Arg Asp Tyr Ala Lys 
            100                 105                 110         


Asp Asp Pro Leu Glu Phe Lys Ser His Gln Trp Phe Gly Ala Ser Val 
        115                 120                 125             


Arg Ser Lys Gln Asp Lys Ile Leu Ala Cys Ala Pro Leu Tyr His Trp 
    130                 135                 140                 


Arg Thr Glu Met Lys Gln Glu Arg Glu Pro Val Gly Thr Cys Phe Leu 
145                 150                 155                 160 


Gln Asp Gly Thr Lys Thr Val Glu Tyr Ala Pro Cys Arg Ser Arg Gln 
                165                 170                 175     


Leu Ile Ser Asp Gln Val Ala Glu Ile Val Ser Lys Tyr Asp Pro Asn 
            180                 185                 190         


Val Tyr Ser Ile Lys Tyr Asn Asn Gln Leu Ala Thr Arg Thr Ala Gln 
        195                 200                 205             


Ala Ile Phe Asp Asp Ser Tyr Leu Gly Tyr Ser Val Ala Val Gly Asp 
    210                 215                 220                 


Phe Asn Gly Asp Gly Ile Asp Asp Phe Val Ser Gly Val Pro Arg Ala 
225                 230                 235                 240 


Ala Arg Thr Leu Gly Met Val Tyr Ile Tyr Asp Gly Lys Asn Met Ser 
                245                 250                 255     


Ser Leu Tyr Asn Phe Thr Gly Glu Gln Met Ala Ala Tyr Phe Gly Phe 
            260                 265                 270         


Ser Val Ala Ala Thr Asp Ile Asn Gly Asp Asp Tyr Ala Asp Val Phe 
        275                 280                 285             


Ile Gly Ala Pro Leu Phe Met Asp Arg Gly Ser Asp Gly Lys Leu Gln 
    290                 295                 300                 


Glu Val Gly Gln Val Ser Val Ser Leu Gln Arg Ala Ser Gly Asp Phe 
305                 310                 315                 320 


Gln Thr Thr Lys Leu Asn Gly Phe Glu Val Phe Ala Arg Phe Gly Ser 
                325                 330                 335     


Ala Ile Ala Pro Leu Gly Asp Leu Asp Gln Asp Gly Phe Asn Asp Ile 
            340                 345                 350         


Ala Ile Ala Ala Pro Tyr Gly Gly Glu Asp Lys Lys Gly Ile Val Tyr 
        355                 360                 365             


Ile Phe Asn Gly Arg Ser Thr Gly Leu Asn Ala Val Pro Ser Gln Ile 
    370                 375                 380                 


Leu Glu Gly Gln Trp Ala Ala Arg Ser Met Pro Pro Ser Phe Gly Tyr 
385                 390                 395                 400 


Ser Met Lys Gly Ala Thr Asp Ile Asp Lys Asn Gly Tyr Pro Asp Leu 
                405                 410                 415     


Ile Val Gly Ala Phe Gly Val Asp Arg Ala Ile Leu Tyr Arg Ala Arg 
            420                 425                 430         


Pro Val Ile Thr Val Asn Ala Gly Leu Glu Val Tyr Pro Ser Ile Leu 
        435                 440                 445             


Asn Gln Asp Asn Lys Thr Cys Ser Leu Pro Gly Thr Ala Leu Lys Val 
    450                 455                 460                 


Ser Cys Phe Asn Val Arg Phe Cys Leu Lys Ala Asp Gly Lys Gly Val 
465                 470                 475                 480 


Leu Pro Arg Lys Leu Asn Phe Gln Val Glu Leu Leu Leu Asp Lys Leu 
                485                 490                 495     


Lys Gln Lys Gly Ala Ile Arg Arg Ala Leu Phe Leu Tyr Ser Arg Ser 
            500                 505                 510         


Pro Ser His Ser Lys Asn Met Thr Ile Ser Arg Gly Gly Leu Met Gln 
        515                 520                 525             


Cys Glu Glu Leu Ile Ala Tyr Leu Arg Asp Glu Ser Glu Phe Arg Asp 
    530                 535                 540                 


Lys Leu Thr Pro Ile Thr Ile Phe Met Glu Tyr Arg Leu Asp Tyr Arg 
545                 550                 555                 560 


Thr Ala Ala Asp Thr Thr Gly Leu Gln Pro Ile Leu Asn Gln Phe Thr 
                565                 570                 575     


Pro Ala Asn Ile Ser Arg Gln Ala His Ile Leu Leu Asp Cys Gly Glu 
            580                 585                 590         


Asp Asn Val Cys Lys Pro Lys Leu Glu Val Ser Val Asp Ser Asp Gln 
        595                 600                 605             


Lys Lys Ile Tyr Ile Gly Asp Asp Asn Pro Leu Thr Leu Ile Val Lys 
    610                 615                 620                 


Ala Gln Asn Gln Gly Glu Gly Ala Tyr Glu Ala Glu Leu Ile Val Ser 
625                 630                 635                 640 


Ile Pro Leu Gln Ala Asp Phe Ile Gly Val Val Arg Asn Asn Glu Ala 
                645                 650                 655     


Leu Ala Arg Leu Ser Cys Ala Phe Lys Thr Glu Asn Gln Thr Arg Gln 
            660                 665                 670         


Val Val Cys Asp Leu Gly Asn Pro Met Lys Ala Gly Thr Gln Leu Leu 
        675                 680                 685             


Ala Gly Leu Arg Phe Ser Val His Gln Gln Ser Glu Met Asp Thr Ser 
    690                 695                 700                 


Val Lys Phe Asp Leu Gln Ile Gln Ser Ser Asn Leu Phe Asp Lys Val 
705                 710                 715                 720 


Ser Pro Val Val Ser His Lys Val Asp Leu Ala Val Leu Ala Ala Val 
                725                 730                 735     


Glu Ile Arg Gly Val Ser Ser Pro Asp His Ile Phe Leu Pro Ile Pro 
            740                 745                 750         


Asn Trp Glu His Lys Glu Asn Pro Glu Thr Glu Glu Asp Val Gly Pro 
        755                 760                 765             


Val Val Gln His Ile Tyr Glu Leu Arg Asn Asn Gly Pro Ser Ser Phe 
    770                 775                 780                 


Ser Lys Ala Met Leu His Leu Gln Trp Pro Tyr Lys Tyr Asn Asn Asn 
785                 790                 795                 800 


Thr Leu Leu Tyr Ile Leu His Tyr Asp Ile Asp Gly Pro Met Asn Cys 
                805                 810                 815     


Thr Ser Asp Met Glu Ile Asn Pro Leu Arg Ile Lys Ile Ser Ser Leu 
            820                 825                 830         


Gln Thr Thr Glu Lys Asn Asp Thr Val Ala Gly Gln Gly Glu Arg Asp 
        835                 840                 845             


His Leu Ile Thr Lys Arg Asp Leu Ala Leu Ser Glu Gly Asp Ile His 
    850                 855                 860                 


Thr Leu Gly Cys Gly Val Ala Gln Cys Leu Lys Ile Val Cys Gln Val 
865                 870                 875                 880 


Gly Arg Leu Asp Arg Gly Lys Ser Ala Ile Leu Tyr Val Lys Ser Leu 
                885                 890                 895     


Leu Trp Thr Glu Thr Phe Met Asn Lys Glu Asn Gln Asn His Ser Tyr 
            900                 905                 910         


Ser Leu Lys Ser Ser Ala Ser Phe Asn Val Ile Glu Phe Pro Tyr Lys 
        915                 920                 925             


Asn Leu Pro Ile Glu Asp Ile Thr Asn Ser Thr Leu Val Thr Thr Asn 
    930                 935                 940                 


Val Thr Trp Gly Ile Gln Pro Ala Pro Met Pro Val Pro Val Trp Val 
945                 950                 955                 960 


Ile Ile Leu Ala Val Leu Ala Gly Leu Leu Leu Leu Ala Val Leu Val 
                965                 970                 975     


Phe Val Met Tyr Arg Met Gly Phe Phe Lys Arg Val Arg Pro Pro Gln 
            980                 985                 990         


Glu Glu Gln Glu Arg Glu Gln Leu  Gln Pro His Glu Asn  Gly Glu Gly 
        995                 1000                 1005             


Asn Ser  Glu Thr 
    1010         


<210>  1804
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  1804

Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val 
1               5                   10                  15      


Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val Ile Met Arg Gly 
145                 150                 155                 160 


Ser Ser Gly Glu Gly Val Ser Cys Thr Ile Arg Ser Ser Leu Leu Gly 
                165                 170                 175     


Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro Phe Phe Arg Ser 
            180                 185                 190         


Ala Gln Arg Trp Ile Ala Ala Leu Ala Gly Thr Leu Pro Val Leu Leu 
        195                 200                 205             


Leu Leu Leu Gly Gly Ala Gly Tyr Phe Leu Trp Gln Gln Gln Glu Glu 
    210                 215                 220                 


Lys Lys Thr Gln Phe Arg Lys Lys Lys Arg Glu Gln Glu Leu Arg Glu 
225                 230                 235                 240 


Met Ala Trp Ser Thr Met Lys Gln Glu Gln Ser Thr Arg Val Lys Leu 
                245                 250                 255     


Leu Glu Glu Leu Arg Trp Arg Ser Ile Gln Tyr Ala Ser Arg Gly Glu 
            260                 265                 270         


Arg His Ser Ala Tyr Asn Glu Trp Lys Lys Ala Leu Phe Lys Pro Ala 
        275                 280                 285             


Asp Val Ile Leu Asp Pro Lys Thr Ala Asn Pro Ile Leu Leu Val Ser 
    290                 295                 300                 


Glu Asp Gln Arg Ser Val Gln Arg Ala Lys Glu Pro Gln Asp Leu Pro 
305                 310                 315                 320 


Asp Asn Pro Glu Arg Phe Asn Trp His Tyr Cys Val Leu Gly Cys Glu 
                325                 330                 335     


Ser Phe Ile Ser Gly Arg His Tyr Trp Glu Val Glu Val Gly Asp Arg 
            340                 345                 350         


Lys Glu Trp His Ile Gly Val Cys Ser Lys Asn Val Gln Arg Lys Gly 
        355                 360                 365             


Trp Val Lys Met Thr Pro Glu Asn Gly Phe Trp Thr Met Gly Leu Thr 
    370                 375                 380                 


Asp Gly Asn Lys Tyr Arg Thr Leu Thr Glu Pro Arg Thr Asn Leu Lys 
385                 390                 395                 400 


Leu Pro Lys Pro Pro Lys Lys Val Gly Val Phe Leu Asp Tyr Glu Thr 
                405                 410                 415     


Gly Asp Ile Ser Phe Tyr Asn Ala Val Asp Gly Ser His Ile His Thr 
            420                 425                 430         


Phe Leu Asp Val Ser Phe Ser Glu Ala Leu Tyr Pro Val Phe Arg Ile 
        435                 440                 445             


Leu Thr Leu Glu Pro Thr Ala Leu Thr Ile Cys Pro Ala 
    450                 455                 460     


<210>  1805
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  1805

Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val 
1               5                   10                  15      


Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Ala Leu Gly Ser Asp Leu His Val Asp Val Lys Gly Tyr Lys Asp Gly 
145                 150                 155                 160 


Gly Ile His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln 
                165                 170                 175     


Ile Gln Trp Ser Asn Asn Lys Gly Glu Asn Ile Pro Thr Val Glu Ala 
            180                 185                 190         


Pro Val Val Ala Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val 
        195                 200                 205             


Ile Met Arg Gly Ser Ser Gly Glu Gly Val Ser Cys Thr Ile Arg Ser 
    210                 215                 220                 


Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro 
225                 230                 235                 240 


Phe Phe Arg Ser Ala Gln Arg Trp Ile Ala Ala Leu Ala Gly Thr Leu 
                245                 250                 255     


Pro Val Leu Leu Leu Leu Leu Gly Gly Ala Gly Tyr Phe Leu Trp Gln 
            260                 265                 270         


Gln Gln Glu Glu Lys Lys Thr Gln Phe Arg Lys Lys Lys Arg Glu Gln 
        275                 280                 285             


Glu Leu Arg Glu Met Ala Trp Ser Thr Met Lys Gln Glu Gln Ser Thr 
    290                 295                 300                 


Arg Val Lys Leu Leu Glu Glu Leu Arg Trp Arg Ser Ile Gln Tyr Ala 
305                 310                 315                 320 


Ser Arg Gly Glu Arg His Ser Ala Tyr Asn Glu Trp Lys Lys Ala Leu 
                325                 330                 335     


Phe Lys Pro Gly Pro Pro Ile Gly Gln Thr Gln Gln Gln Thr Arg Gly 
            340                 345                 350         


Gln Gly Ser Pro Val Ala Leu Ser Gln Glu Ser Ala Gln Arg Thr Asp 
        355                 360                 365             


Ser Trp Gly Pro Glu Glu Gly Gly Glu Ser 
    370                 375             


<210>  1806
<211>  692
<212>  PRT
<213>  Homo sapiens

<400>  1806

Met Gln Gly Lys Lys Pro Gly Gly Ser Ser Gly Gly Gly Arg Ser Gly 
1               5                   10                  15      


Glu Leu Gln Gly Asp Glu Ala Gln Arg Asn Lys Lys Lys Lys Lys Lys 
            20                  25                  30          


Val Ser Cys Phe Ser Asn Ile Lys Ile Phe Leu Val Ser Glu Cys Ala 
        35                  40                  45              


Leu Met Leu Ala Gln Gly Thr Val Gly Ala Tyr Leu Val Ser Val Leu 
    50                  55                  60                  


Thr Thr Leu Glu Arg Arg Phe Asn Leu Gln Ser Ala Asp Val Gly Val 
65                  70                  75                  80  


Ile Ala Ser Ser Phe Glu Ile Gly Asn Leu Ala Leu Ile Leu Phe Val 
                85                  90                  95      


Ser Tyr Phe Gly Ala Arg Gly His Arg Pro Arg Leu Ile Gly Cys Gly 
            100                 105                 110         


Gly Ile Val Met Ala Leu Gly Ala Leu Leu Ser Ala Leu Pro Glu Phe 
        115                 120                 125             


Leu Thr His Gln Tyr Lys Tyr Glu Ala Gly Glu Ile Arg Trp Gly Ala 
    130                 135                 140                 


Glu Gly Arg Asp Val Cys Ala Ala Asn Gly Ser Gly Gly Asp Glu Gly 
145                 150                 155                 160 


Pro Asp Pro Asp Leu Ile Cys Arg Asn Arg Thr Ala Thr Asn Met Met 
                165                 170                 175     


Tyr Leu Leu Leu Ile Gly Ala Gln Val Leu Leu Gly Ile Gly Ala Thr 
            180                 185                 190         


Pro Val Gln Pro Leu Gly Val Ser Tyr Ile Asp Asp His Val Arg Arg 
        195                 200                 205             


Lys Asp Ser Ser Leu Tyr Ile Gly Ile Leu Phe Thr Met Leu Val Phe 
    210                 215                 220                 


Gly Pro Ala Cys Gly Phe Ile Leu Gly Ser Phe Cys Thr Lys Ile Tyr 
225                 230                 235                 240 


Val Asp Ala Val Phe Ile Asp Thr Ser Asn Leu Asp Ile Thr Pro Asp 
                245                 250                 255     


Asp Pro Arg Trp Ile Gly Ala Trp Trp Gly Gly Phe Leu Leu Cys Gly 
            260                 265                 270         


Ala Leu Leu Phe Phe Ser Ser Leu Leu Met Phe Gly Phe Pro Gln Ser 
        275                 280                 285             


Leu Pro Pro His Ser Glu Pro Ala Met Glu Ser Glu Gln Ala Met Leu 
    290                 295                 300                 


Ser Glu Arg Glu Tyr Glu Arg Pro Lys Pro Ser Asn Gly Val Leu Arg 
305                 310                 315                 320 


His Pro Leu Glu Pro Asp Ser Ser Ala Ser Cys Phe Gln Gln Leu Arg 
                325                 330                 335     


Val Ile Pro Lys Val Thr Lys His Leu Leu Ser Asn Pro Val Phe Thr 
            340                 345                 350         


Cys Ile Ile Leu Ala Ala Cys Met Glu Ile Ala Val Val Ala Gly Phe 
        355                 360                 365             


Ala Ala Phe Leu Gly Lys Tyr Leu Glu Gln Gln Phe Asn Leu Thr Thr 
    370                 375                 380                 


Ser Ser Ala Asn Gln Leu Leu Gly Met Thr Ala Ile Pro Cys Ala Cys 
385                 390                 395                 400 


Leu Gly Ile Phe Leu Gly Gly Leu Leu Val Lys Lys Leu Ser Leu Ser 
                405                 410                 415     


Ala Leu Gly Ala Ile Arg Met Ala Met Leu Val Asn Leu Val Ser Thr 
            420                 425                 430         


Ala Cys Tyr Val Ser Phe Leu Phe Leu Gly Cys Asp Thr Gly Pro Val 
        435                 440                 445             


Ala Gly Val Thr Val Pro Tyr Gly Asn Ser Thr Ala Pro Gly Ser Ala 
    450                 455                 460                 


Leu Asp Pro Tyr Ser Pro Cys Asn Asn Asn Cys Glu Cys Gln Thr Asp 
465                 470                 475                 480 


Ser Phe Thr Pro Val Cys Gly Ala Asp Gly Ile Thr Tyr Leu Ser Ala 
                485                 490                 495     


Cys Phe Ala Gly Cys Asn Ser Thr Asn Leu Thr Gly Cys Ala Cys Leu 
            500                 505                 510         


Thr Thr Val Pro Ala Glu Asn Ala Thr Val Val Pro Gly Lys Cys Pro 
        515                 520                 525             


Ser Pro Gly Cys Gln Glu Ala Phe Leu Thr Phe Leu Cys Val Met Cys 
    530                 535                 540                 


Ile Cys Ser Leu Ile Gly Ala Met Ala Gln Thr Pro Ser Val Ile Ile 
545                 550                 555                 560 


Leu Ile Arg Thr Val Ser Pro Glu Leu Lys Ser Tyr Ala Leu Gly Val 
                565                 570                 575     


Leu Phe Leu Leu Leu Arg Leu Leu Gly Phe Ile Pro Pro Pro Leu Ile 
            580                 585                 590         


Phe Gly Ala Gly Ile Asp Ser Thr Cys Leu Phe Trp Ser Thr Phe Cys 
        595                 600                 605             


Gly Glu Gln Gly Ala Cys Val Leu Tyr Asp Asn Val Val Tyr Arg Tyr 
    610                 615                 620                 


Leu Tyr Val Ser Ile Ala Ile Ala Leu Lys Ser Phe Ala Phe Ile Leu 
625                 630                 635                 640 


Tyr Thr Thr Thr Trp Gln Cys Leu Arg Lys Asn Tyr Lys Arg Tyr Ile 
                645                 650                 655     


Lys Asn His Glu Gly Gly Leu Ser Thr Ser Thr Glu Tyr Gln Asp Ile 
            660                 665                 670         


Glu Thr Glu Lys Thr Cys Pro Glu Ser His Ser Pro Ser Glu Asp Ser 
        675                 680                 685             


Phe Val Arg Ser 
    690         


<210>  1807
<211>  704
<212>  PRT
<213>  Homo sapiens

<400>  1807

Met Glu Asp Glu Arg Lys Asn Gly Ala Tyr Gly Thr Pro Gln Lys Tyr 
1               5                   10                  15      


Asp Pro Thr Phe Lys Gly Pro Ile Tyr Asn Arg Gly Cys Thr Asp Ile 
            20                  25                  30          


Ile Cys Cys Val Phe Leu Leu Leu Ala Ile Val Gly Tyr Val Ala Val 
        35                  40                  45              


Gly Ile Ile Ala Trp Thr His Gly Asp Pro Arg Lys Val Ile Tyr Pro 
    50                  55                  60                  


Thr Asp Ser Arg Gly Glu Phe Cys Gly Gln Lys Gly Thr Lys Asn Glu 
65                  70                  75                  80  


Asn Lys Pro Tyr Leu Phe Tyr Phe Asn Ile Val Lys Cys Ala Ser Pro 
                85                  90                  95      


Leu Val Leu Leu Glu Phe Gln Cys Pro Thr Pro Gln Ile Cys Val Glu 
            100                 105                 110         


Lys Cys Pro Asp Arg Tyr Leu Thr Tyr Leu Asn Ala Arg Ser Ser Arg 
        115                 120                 125             


Asp Phe Glu Tyr Tyr Lys Gln Phe Cys Val Pro Gly Phe Lys Asn Asn 
    130                 135                 140                 


Lys Gly Val Ala Glu Val Leu Gln Asp Gly Asp Cys Pro Ala Val Leu 
145                 150                 155                 160 


Ile Pro Ser Lys Pro Leu Ala Arg Arg Cys Phe Pro Ala Ile His Ala 
                165                 170                 175     


Tyr Lys Gly Val Leu Met Val Gly Asn Glu Thr Thr Tyr Glu Asp Gly 
            180                 185                 190         


His Gly Ser Arg Lys Asn Ile Thr Asp Leu Val Glu Gly Ala Lys Lys 
        195                 200                 205             


Ala Asn Gly Val Leu Glu Ala Arg Gln Leu Ala Met Arg Ile Phe Glu 
    210                 215                 220                 


Asp Tyr Thr Val Ser Trp Tyr Trp Ile Ile Ile Gly Leu Val Ile Ala 
225                 230                 235                 240 


Met Ala Met Ser Leu Leu Phe Ile Ile Leu Leu Arg Phe Leu Ala Gly 
                245                 250                 255     


Ile Met Val Trp Val Met Ile Ile Met Val Ile Leu Val Leu Gly Tyr 
            260                 265                 270         


Gly Ile Phe His Cys Tyr Met Glu Tyr Ser Arg Leu Arg Gly Glu Ala 
        275                 280                 285             


Gly Ser Asp Val Ser Leu Val Asp Leu Gly Phe Gln Thr Asp Phe Arg 
    290                 295                 300                 


Val Tyr Leu His Leu Arg Gln Thr Trp Leu Ala Phe Met Ile Ile Leu 
305                 310                 315                 320 


Ser Ile Leu Glu Val Ile Ile Ile Leu Leu Leu Ile Phe Leu Arg Lys 
                325                 330                 335     


Arg Ile Leu Ile Ala Ile Ala Leu Ile Lys Glu Ala Ser Arg Ala Val 
            340                 345                 350         


Gly Tyr Val Met Cys Ser Leu Leu Tyr Pro Leu Val Thr Phe Phe Leu 
        355                 360                 365             


Leu Cys Leu Cys Ile Ala Tyr Trp Ala Ser Thr Ala Val Phe Leu Ser 
    370                 375                 380                 


Thr Ser Asn Glu Ala Val Tyr Lys Ile Phe Asp Asp Ser Pro Cys Pro 
385                 390                 395                 400 


Phe Thr Ala Lys Thr Cys Asn Pro Glu Thr Phe Pro Ser Ser Asn Glu 
                405                 410                 415     


Ser Arg Gln Cys Pro Asn Ala Arg Cys Gln Phe Ala Phe Tyr Gly Gly 
            420                 425                 430         


Glu Ser Gly Tyr His Arg Ala Leu Leu Gly Leu Gln Ile Phe Asn Ala 
        435                 440                 445             


Phe Met Phe Phe Trp Leu Ala Asn Phe Val Leu Ala Leu Gly Gln Val 
    450                 455                 460                 


Thr Leu Ala Gly Ala Phe Ala Ser Tyr Tyr Trp Ala Leu Arg Lys Pro 
465                 470                 475                 480 


Asp Asp Leu Pro Ala Phe Pro Leu Phe Ser Ala Phe Gly Arg Ala Leu 
                485                 490                 495     


Arg Tyr His Thr Gly Ser Leu Ala Phe Gly Ala Leu Ile Leu Ala Ile 
            500                 505                 510         


Val Gln Ile Ile Arg Val Ile Leu Glu Tyr Leu Asp Gln Arg Leu Lys 
        515                 520                 525             


Ala Ala Glu Asn Lys Phe Ala Lys Cys Leu Met Thr Cys Leu Lys Cys 
    530                 535                 540                 


Cys Phe Trp Cys Leu Glu Lys Phe Ile Lys Phe Leu Asn Arg Asn Ala 
545                 550                 555                 560 


Tyr Ile Met Ile Ala Ile Tyr Gly Thr Asn Phe Cys Thr Ser Ala Arg 
                565                 570                 575     


Asn Ala Phe Phe Leu Leu Met Arg Asn Ile Ile Arg Val Ala Val Leu 
            580                 585                 590         


Asp Lys Val Thr Asp Phe Leu Phe Leu Leu Gly Lys Leu Leu Ile Val 
        595                 600                 605             


Gly Ser Val Gly Ile Leu Ala Phe Phe Phe Phe Thr His Arg Ile Arg 
    610                 615                 620                 


Ile Val Gln Asp Thr Ala Pro Pro Leu Asn Tyr Tyr Trp Val Pro Ile 
625                 630                 635                 640 


Leu Thr Val Ile Val Gly Ser Tyr Leu Ile Ala His Gly Phe Phe Ser 
                645                 650                 655     


Val Tyr Gly Met Cys Val Asp Thr Leu Phe Leu Cys Phe Leu Glu Asp 
            660                 665                 670         


Leu Glu Arg Asn Asp Gly Ser Ala Glu Arg Pro Tyr Phe Met Ser Ser 
        675                 680                 685             


Thr Leu Lys Lys Leu Leu Asn Lys Thr Asn Lys Lys Ala Ala Glu Ser 
    690                 695                 700                 


<210>  1808
<211>  438
<212>  PRT
<213>  Homo sapiens

<400>  1808

Met Cys Lys Asp Tyr Val Tyr Asp Lys Asp Ile Glu Gln Ile Ala Lys 
1               5                   10                  15      


Glu Glu Gln Gly Glu Ala Leu Lys Leu Gln Ala Ser Thr Ser Thr Glu 
            20                  25                  30          


Val Ser His Gln Gln Cys Ser Val Pro Gly Leu Gly Glu Lys Phe Pro 
        35                  40                  45              


Thr Trp Glu Thr Thr Lys Pro Glu Leu Glu Leu Leu Gly His Asn Pro 
    50                  55                  60                  


Arg Arg Arg Arg Ile Thr Ser Ser Phe Thr Ile Gly Leu Arg Gly Leu 
65                  70                  75                  80  


Ile Asn Leu Gly Asn Thr Cys Phe Met Asn Cys Ile Val Gln Ala Leu 
                85                  90                  95      


Thr His Thr Pro Ile Leu Arg Asp Phe Phe Leu Ser Asp Arg His Arg 
            100                 105                 110         


Cys Glu Met Pro Ser Pro Glu Leu Cys Leu Val Cys Glu Met Ser Ser 
        115                 120                 125             


Leu Phe Arg Glu Leu Tyr Ser Gly Asn Pro Ser Pro His Val Pro Tyr 
    130                 135                 140                 


Lys Leu Leu His Leu Val Trp Ile His Ala Arg His Leu Ala Gly Tyr 
145                 150                 155                 160 


Arg Gln Gln Asp Ala His Glu Phe Leu Ile Ala Ala Leu Asp Val Leu 
                165                 170                 175     


His Arg His Cys Lys Gly Asp Asp Val Gly Lys Ala Ala Asn Asn Pro 
            180                 185                 190         


Asn His Cys Asn Cys Ile Ile Asp Gln Ile Phe Thr Gly Gly Leu Gln 
        195                 200                 205             


Ser Asp Val Thr Cys Gln Ala Cys His Gly Val Ser Thr Thr Ile Asp 
    210                 215                 220                 


Pro Cys Trp Asp Ile Ser Leu Asp Leu Pro Gly Ser Cys Thr Ser Phe 
225                 230                 235                 240 


Trp Pro Met Ser Pro Gly Arg Glu Ser Ser Val Asn Gly Glu Ser His 
                245                 250                 255     


Ile Pro Gly Ile Thr Thr Leu Thr Asp Cys Leu Arg Arg Phe Thr Arg 
            260                 265                 270         


Pro Glu His Leu Gly Ser Ser Ala Lys Ile Lys Cys Gly Ser Cys Gln 
        275                 280                 285             


Ser Tyr Gln Glu Ser Thr Lys Gln Leu Thr Met Asn Lys Leu Pro Val 
    290                 295                 300                 


Val Ala Cys Phe His Phe Lys Arg Phe Glu His Ser Ala Lys Gln Arg 
305                 310                 315                 320 


Arg Lys Ile Thr Thr Tyr Ile Ser Phe Pro Leu Glu Leu Asp Met Thr 
                325                 330                 335     


Pro Phe Met Ala Ser Ser Lys Glu Ser Arg Met Asn Gly Gln Leu Gln 
            340                 345                 350         


Leu Pro Thr Asn Ser Gly Asn Asn Glu Asn Lys Tyr Ser Leu Phe Ala 
        355                 360                 365             


Val Val Asn His Gln Gly Thr Leu Glu Ser Gly His Tyr Thr Ser Phe 
    370                 375                 380                 


Ile Arg His His Lys Asp Gln Trp Phe Lys Cys Asp Asp Ala Val Ile 
385                 390                 395                 400 


Thr Lys Ala Ser Ile Lys Asp Val Leu Asp Ser Glu Gly Tyr Leu Leu 
                405                 410                 415     


Phe Tyr His Lys Gln Val Leu Glu His Glu Ser Glu Lys Val Lys Glu 
            420                 425                 430         


Met Asn Thr Gln Ala Tyr 
        435             


<210>  1809
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  1809

Met Gln Glu Pro Leu Leu Gly Ala Glu Gly Pro Asp Tyr Asp Thr Phe 
1               5                   10                  15      


Pro Glu Lys Pro Pro Pro Ser Pro Gly Asp Arg Ala Arg Val Gly Thr 
            20                  25                  30          


Leu Gln Asn Lys Arg Val Phe Leu Ala Thr Phe Ala Ala Val Leu Gly 
        35                  40                  45              


Asn Phe Ser Phe Gly Tyr Ala Leu Val Tyr Thr Ser Pro Val Ile Pro 
    50                  55                  60                  


Ala Leu Glu Arg Ser Leu Asp Pro Asp Leu His Leu Thr Lys Ser Gln 
65                  70                  75                  80  


Ala Ser Trp Phe Gly Ser Val Phe Thr Leu Gly Ala Ala Ala Gly Gly 
                85                  90                  95      


Leu Ser Ala Met Ile Leu Asn Asp Leu Leu Gly Arg Lys Leu Ser Ile 
            100                 105                 110         


Met Phe Ser Ala Val Pro Ser Ala Ala Gly Tyr Ala Leu Met Ala Gly 
        115                 120                 125             


Ala His Gly Leu Trp Met Leu Leu Leu Gly Arg Thr Leu Thr Gly Phe 
    130                 135                 140                 


Ala Gly Gly Leu Thr Ala Ala Cys Ile Pro Val Tyr Val Ser Glu Ile 
145                 150                 155                 160 


Ala Pro Pro Gly Val Arg Gly Ala Leu Gly Ala Thr Pro Gln Leu Met 
                165                 170                 175     


Ala Val Phe Gly Ser Leu Ser Leu Tyr Ala Leu Gly Leu Leu Leu Pro 
            180                 185                 190         


Trp Arg Trp Leu Ala Val Ala Gly Glu Ala Pro Val Leu Ile Met Ile 
        195                 200                 205             


Leu Leu Leu Ser Phe Met Pro Asn Ser Pro Arg Phe Leu Leu Ser Arg 
    210                 215                 220                 


Gly Arg Asp Glu Glu Ala Leu Arg Ala Leu Ala Trp Leu Arg Gly Thr 
225                 230                 235                 240 


Asp Val Asp Val His Trp Glu Phe Glu Gln Ile Gln Asp Asn Val Arg 
                245                 250                 255     


Arg Gln Ser Ser Arg Val Ser Trp Ala Glu Ala Arg Ala Pro His Val 
            260                 265                 270         


Cys Arg Pro Ile Thr Val Ala Leu Leu Met Arg Leu Leu Gln Gln Leu 
        275                 280                 285             


Thr Gly Ile Thr Pro Ile Leu Val Tyr Leu Gln Ser Ile Phe Asp Ser 
    290                 295                 300                 


Thr Ala Val Leu Leu Pro Pro Lys Asp Asp Ala Ala Ile Val Gly Ala 
305                 310                 315                 320 


Val Arg Leu Leu Ser Val Leu Ile Ala Ala Leu Thr Met Asp Leu Ala 
                325                 330                 335     


Gly Arg Lys Val Leu Leu Phe Val Ser Gly Tyr Ala Val Gly Trp Gly 
            340                 345                 350         


Pro Ile Thr Trp Leu Leu Met Ser Glu Val Leu Pro Leu Arg Ala Arg 
        355                 360                 365             


Gly Val Ala Ser Gly Leu Cys Val Leu Ala Ser Trp Leu Thr Ala Phe 
    370                 375                 380                 


Val Leu Thr Lys Ser Phe Leu Pro Val Val Ser Thr Phe Gly Leu Gln 
385                 390                 395                 400 


Val Pro Phe Phe Phe Phe Ala Ala Ile Cys Leu Val Ser Leu Val Phe 
                405                 410                 415     


Thr Gly Cys Cys Val Pro Glu Thr Lys Gly Arg Ser Leu Glu Gln Ile 
            420                 425                 430         


Glu Ser Phe Phe Arg Thr Gly Arg Arg Ser Phe Leu Arg 
        435                 440                 445 


<210>  1810
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  1810

Met Val Asn Asp Arg Trp Lys Thr Met Gly Gly Ala Ala Gln Leu Glu 
1               5                   10                  15      


Asp Arg Pro Arg Asp Lys Pro Gln Arg Pro Ser Cys Gly Tyr Val Leu 
            20                  25                  30          


Cys Thr Val Leu Leu Ala Leu Ala Val Leu Leu Ala Val Ala Val Thr 
        35                  40                  45              


Gly Ala Val Leu Phe Leu Asn His Ala His Ala Pro Gly Thr Ala Pro 
    50                  55                  60                  


Pro Pro Val Val Ser Thr Gly Ala Ala Ser Ala Asn Ser Ala Leu Val 
65                  70                  75                  80  


Thr Val Glu Arg Ala Asp Ser Ser His Leu Ser Ile Leu Ile Asp Pro 
                85                  90                  95      


Arg Cys Pro Asp Leu Thr Asp Ser Phe Ala Arg Leu Glu Ser Ala Gln 
            100                 105                 110         


Ala Ser Val Leu Gln Ala Leu Thr Glu His Gln Ala Gln Pro Arg Leu 
        115                 120                 125             


Val Gly Asp Gln Glu Gln Glu Leu Leu Asp Thr Leu Ala Asp Gln Leu 
    130                 135                 140                 


Pro Arg Leu Leu Ala Arg Ala Ser Glu Leu Gln Thr Glu Cys Met Gly 
145                 150                 155                 160 


Leu Arg Lys Gly His Gly Thr Leu Gly Gln Gly Leu Ser Ala Leu Gln 
                165                 170                 175     


Ser Glu Gln Gly Arg Leu Ile Gln Leu Leu Ser Glu Ser Gln Gly His 
            180                 185                 190         


Met Ala His Leu Val Asn Ser Val Ser Asp Ile Leu Asp Ala Leu Gln 
        195                 200                 205             


Arg Asp Arg Gly Leu Gly Arg Pro Arg Asn Lys Ala Asp Leu Gln Arg 
    210                 215                 220                 


Ala Pro Ala Arg Gly Thr Arg Pro Arg Gly Cys Ala Thr Gly Ser Arg 
225                 230                 235                 240 


Pro Arg Asp Cys Leu Asp Val Leu Leu Ser Gly Gln Gln Asp Asp Gly 
                245                 250                 255     


Val Tyr Ser Val Phe Pro Thr His Tyr Pro Ala Gly Phe Gln Val Tyr 
            260                 265                 270         


Cys Asp Met Arg Thr Asp Gly Gly Gly Trp Thr Val Phe Gln Arg Arg 
        275                 280                 285             


Glu Asp Gly Ser Val Asn Phe Phe Arg Gly Trp Asp Ala Tyr Arg Asp 
    290                 295                 300                 


Gly Phe Gly Arg Leu Thr Gly Glu His Trp Leu Gly Leu Lys Arg Ile 
305                 310                 315                 320 


His Ala Leu Thr Thr Gln Ala Ala Tyr Glu Leu His Val Asp Leu Glu 
                325                 330                 335     


Asp Phe Glu Asn Gly Thr Ala Tyr Ala Arg Tyr Gly Ser Phe Gly Val 
            340                 345                 350         


Gly Leu Phe Ser Val Asp Pro Glu Glu Asp Gly Tyr Pro Leu Thr Val 
        355                 360                 365             


Ala Asp Tyr Ser Gly Thr Ala Gly Asp Ser Leu Leu Lys His Ser Gly 
    370                 375                 380                 


Met Arg Phe Thr Thr Lys Asp Arg Asp Ser Asp His Ser Glu Asn Asn 
385                 390                 395                 400 


Cys Ala Ala Phe Tyr Arg Gly Ala Trp Trp Tyr Arg Asn Cys His Thr 
                405                 410                 415     


Ser Asn Leu Asn Gly Gln Tyr Leu Arg Gly Ala His Ala Ser Tyr Ala 
            420                 425                 430         


Asp Gly Val Glu Trp Ser Ser Trp Thr Gly Trp Gln Tyr Ser Leu Lys 
        435                 440                 445             


Phe Ser Glu Met Lys Ile Arg Pro Val Arg Glu Asp Arg 
    450                 455                 460     


<210>  1811
<211>  866
<212>  PRT
<213>  Homo sapiens

<400>  1811

Met Gly Phe Pro Pro Leu Leu Lys Gly Gln Ala Ser Ala Thr Arg Ser 
1               5                   10                  15      


Ser Leu Ala Ser Cys Ser Trp Val Val Phe Phe Leu Ser Cys Leu Ser 
            20                  25                  30          


Arg His Ala Pro Glu Ile Glu Gly Gly Arg Arg Trp Thr Glu Leu Ile 
        35                  40                  45              


Arg Thr Met Glu Ser Arg Val Leu Leu Arg Thr Phe Cys Leu Ile Phe 
    50                  55                  60                  


Gly Leu Gly Ala Val Trp Gly Leu Gly Val Asp Pro Ser Leu Gln Ile 
65                  70                  75                  80  


Asp Val Leu Thr Glu Leu Glu Leu Gly Glu Ser Thr Thr Gly Val Arg 
                85                  90                  95      


Gln Val Pro Gly Leu His Asn Gly Thr Lys Ala Phe Leu Phe Gln Asp 
            100                 105                 110         


Thr Pro Arg Ser Ile Lys Ala Ser Thr Ala Thr Ala Glu Gln Phe Phe 
        115                 120                 125             


Gln Lys Leu Arg Asn Lys His Glu Phe Thr Ile Leu Val Thr Leu Lys 
    130                 135                 140                 


Gln Thr His Leu Asn Ser Gly Val Ile Leu Ser Ile His His Leu Asp 
145                 150                 155                 160 


His Arg Tyr Leu Glu Leu Glu Ser Ser Gly His Arg Asn Glu Val Arg 
                165                 170                 175     


Leu His Tyr Arg Ser Gly Ser His Arg Pro His Thr Glu Val Phe Pro 
            180                 185                 190         


Tyr Ile Leu Ala Asp Asp Lys Trp His Lys Leu Ser Leu Ala Ile Ser 
        195                 200                 205             


Ala Ser His Leu Ile Leu His Ile Asp Cys Asn Lys Ile Tyr Glu Arg 
    210                 215                 220                 


Val Val Glu Lys Pro Ser Thr Asp Leu Pro Leu Gly Thr Thr Phe Trp 
225                 230                 235                 240 


Leu Gly Gln Arg Asn Asn Ala His Gly Tyr Phe Lys Gly Ile Met Gln 
                245                 250                 255     


Asp Val Gln Leu Leu Val Met Pro Gln Gly Phe Ile Ala Gln Cys Pro 
            260                 265                 270         


Asp Leu Asn Arg Thr Cys Pro Thr Cys Asn Asp Phe His Gly Leu Val 
        275                 280                 285             


Gln Lys Ile Met Glu Leu Gln Asp Ile Leu Ala Lys Thr Ser Ala Lys 
    290                 295                 300                 


Leu Ser Arg Ala Glu Gln Arg Met Asn Arg Leu Asp Gln Cys Tyr Cys 
305                 310                 315                 320 


Glu Arg Thr Cys Thr Met Lys Gly Thr Thr Tyr Arg Glu Phe Glu Ser 
                325                 330                 335     


Trp Ile Asp Gly Cys Lys Asn Cys Thr Cys Leu Asn Gly Thr Ile Gln 
            340                 345                 350         


Cys Glu Thr Leu Ile Cys Pro Asn Pro Asp Cys Pro Leu Lys Ser Ala 
        355                 360                 365             


Leu Ala Tyr Val Asp Gly Lys Cys Cys Lys Glu Cys Lys Ser Ile Cys 
    370                 375                 380                 


Gln Phe Gln Gly Arg Thr Tyr Phe Glu Gly Glu Arg Asn Thr Val Tyr 
385                 390                 395                 400 


Ser Ser Ser Gly Val Cys Val Leu Tyr Glu Cys Lys Asp Gln Thr Met 
                405                 410                 415     


Lys Leu Val Glu Ser Ser Gly Cys Pro Ala Leu Asp Cys Pro Glu Ser 
            420                 425                 430         


His Gln Ile Thr Leu Ser His Ser Cys Cys Lys Val Cys Lys Gly Tyr 
        435                 440                 445             


Asp Phe Cys Ser Glu Arg His Asn Cys Met Glu Asn Ser Ile Cys Arg 
    450                 455                 460                 


Asn Leu Asn Asp Arg Ala Val Cys Ser Cys Arg Asp Gly Phe Arg Ala 
465                 470                 475                 480 


Leu Arg Glu Asp Asn Ala Tyr Cys Glu Asp Ile Asp Glu Cys Ala Glu 
                485                 490                 495     


Gly Arg His Tyr Cys Arg Glu Asn Thr Met Cys Val Asn Thr Pro Gly 
            500                 505                 510         


Ser Phe Met Cys Ile Cys Lys Thr Gly Tyr Ile Arg Ile Asp Asp Tyr 
        515                 520                 525             


Ser Cys Thr Glu His Asp Glu Cys Ile Thr Asn Gln His Asn Cys Asp 
    530                 535                 540                 


Glu Asn Ala Leu Cys Phe Asn Thr Val Gly Gly His Asn Cys Val Cys 
545                 550                 555                 560 


Lys Pro Gly Tyr Thr Gly Asn Gly Thr Thr Cys Lys Ala Phe Cys Lys 
                565                 570                 575     


Asp Gly Cys Arg Asn Gly Gly Ala Cys Ile Ala Ala Asn Val Cys Ala 
            580                 585                 590         


Cys Pro Gln Gly Phe Thr Gly Pro Ser Cys Glu Thr Asp Ile Asp Glu 
        595                 600                 605             


Cys Ser Asp Gly Phe Val Gln Cys Asp Ser Arg Ala Asn Cys Ile Asn 
    610                 615                 620                 


Leu Pro Gly Trp Tyr His Cys Glu Cys Arg Asp Gly Tyr His Asp Asn 
625                 630                 635                 640 


Gly Met Phe Ser Pro Ser Gly Glu Ser Cys Glu Asp Ile Asp Glu Cys 
                645                 650                 655     


Gly Thr Gly Arg His Ser Cys Ala Asn Asp Thr Ile Cys Phe Asn Leu 
            660                 665                 670         


Asp Gly Gly Tyr Asp Cys Arg Cys Pro His Gly Lys Asn Cys Thr Gly 
        675                 680                 685             


Asp Cys Ile His Asp Gly Lys Val Lys His Asn Gly Gln Ile Trp Val 
    690                 695                 700                 


Leu Glu Asn Asp Arg Cys Ser Val Cys Ser Cys Gln Asn Gly Phe Val 
705                 710                 715                 720 


Met Cys Arg Arg Met Val Cys Asp Cys Glu Asn Pro Thr Val Asp Leu 
                725                 730                 735     


Phe Cys Cys Pro Glu Cys Asp Pro Arg Leu Ser Ser Gln Cys Leu His 
            740                 745                 750         


Gln Asn Gly Glu Thr Leu Tyr Asn Ser Gly Asp Thr Trp Val Gln Asn 
        755                 760                 765             


Cys Gln Gln Cys Arg Cys Leu Gln Gly Glu Val Asp Cys Trp Pro Leu 
    770                 775                 780                 


Pro Cys Pro Asp Val Glu Cys Glu Phe Ser Ile Leu Pro Glu Asn Glu 
785                 790                 795                 800 


Cys Cys Pro Arg Cys Val Thr Asp Pro Cys Gln Ala Asp Thr Ile Arg 
                805                 810                 815     


Asn Asp Ile Thr Lys Thr Cys Leu Asp Glu Met Asn Val Val Arg Phe 
            820                 825                 830         


Thr Gly Ser Ser Trp Ile Lys His Gly Thr Glu Cys Thr Leu Cys Gln 
        835                 840                 845             


Cys Lys Asn Gly His Ile Cys Cys Ser Val Asp Pro Gln Cys Leu Gln 
    850                 855                 860                 


Glu Leu 
865     


<210>  1812
<211>  816
<212>  PRT
<213>  Homo sapiens

<400>  1812

Met Glu Ser Arg Val Leu Leu Arg Thr Phe Cys Leu Ile Phe Gly Leu 
1               5                   10                  15      


Gly Ala Val Trp Gly Leu Gly Val Asp Pro Ser Leu Gln Ile Asp Val 
            20                  25                  30          


Leu Thr Glu Leu Glu Leu Gly Glu Ser Thr Thr Gly Val Arg Gln Val 
        35                  40                  45              


Pro Gly Leu His Asn Gly Thr Lys Ala Phe Leu Phe Gln Asp Thr Pro 
    50                  55                  60                  


Arg Ser Ile Lys Ala Ser Thr Ala Thr Ala Glu Gln Phe Phe Gln Lys 
65                  70                  75                  80  


Leu Arg Asn Lys His Glu Phe Thr Ile Leu Val Thr Leu Lys Gln Thr 
                85                  90                  95      


His Leu Asn Ser Gly Val Ile Leu Ser Ile His His Leu Asp His Arg 
            100                 105                 110         


Tyr Leu Glu Leu Glu Ser Ser Gly His Arg Asn Glu Val Arg Leu His 
        115                 120                 125             


Tyr Arg Ser Gly Ser His Arg Pro His Thr Glu Val Phe Pro Tyr Ile 
    130                 135                 140                 


Leu Ala Asp Asp Lys Trp His Lys Leu Ser Leu Ala Ile Ser Ala Ser 
145                 150                 155                 160 


His Leu Ile Leu His Ile Asp Cys Asn Lys Ile Tyr Glu Arg Val Val 
                165                 170                 175     


Glu Lys Pro Ser Thr Asp Leu Pro Leu Gly Thr Thr Phe Trp Leu Gly 
            180                 185                 190         


Gln Arg Asn Asn Ala His Gly Tyr Phe Lys Gly Ile Met Gln Asp Val 
        195                 200                 205             


Gln Leu Leu Val Met Pro Gln Gly Phe Ile Ala Gln Cys Pro Asp Leu 
    210                 215                 220                 


Asn Arg Thr Cys Pro Thr Cys Asn Asp Phe His Gly Leu Val Gln Lys 
225                 230                 235                 240 


Ile Met Glu Leu Gln Asp Ile Leu Ala Lys Thr Ser Ala Lys Leu Ser 
                245                 250                 255     


Arg Ala Glu Gln Arg Met Asn Arg Leu Asp Gln Cys Tyr Cys Glu Arg 
            260                 265                 270         


Thr Cys Thr Met Lys Gly Thr Thr Tyr Arg Glu Phe Glu Ser Trp Ile 
        275                 280                 285             


Asp Gly Cys Lys Asn Cys Thr Cys Leu Asn Gly Thr Ile Gln Cys Glu 
    290                 295                 300                 


Thr Leu Ile Cys Pro Asn Pro Asp Cys Pro Leu Lys Ser Ala Leu Ala 
305                 310                 315                 320 


Tyr Val Asp Gly Lys Cys Cys Lys Glu Cys Lys Ser Ile Cys Gln Phe 
                325                 330                 335     


Gln Gly Arg Thr Tyr Phe Glu Gly Glu Arg Asn Thr Val Tyr Ser Ser 
            340                 345                 350         


Ser Gly Val Cys Val Leu Tyr Glu Cys Lys Asp Gln Thr Met Lys Leu 
        355                 360                 365             


Val Glu Ser Ser Gly Cys Pro Ala Leu Asp Cys Pro Glu Ser His Gln 
    370                 375                 380                 


Ile Thr Leu Ser His Ser Cys Cys Lys Val Cys Lys Gly Tyr Asp Phe 
385                 390                 395                 400 


Cys Ser Glu Arg His Asn Cys Met Glu Asn Ser Ile Cys Arg Asn Leu 
                405                 410                 415     


Asn Asp Arg Ala Val Cys Ser Cys Arg Asp Gly Phe Arg Ala Leu Arg 
            420                 425                 430         


Glu Asp Asn Ala Tyr Cys Glu Asp Ile Asp Glu Cys Ala Glu Gly Arg 
        435                 440                 445             


His Tyr Cys Arg Glu Asn Thr Met Cys Val Asn Thr Pro Gly Ser Phe 
    450                 455                 460                 


Met Cys Ile Cys Lys Thr Gly Tyr Ile Arg Ile Asp Asp Tyr Ser Cys 
465                 470                 475                 480 


Thr Glu His Asp Glu Cys Ile Thr Asn Gln His Asn Cys Asp Glu Asn 
                485                 490                 495     


Ala Leu Cys Phe Asn Thr Val Gly Gly His Asn Cys Val Cys Lys Pro 
            500                 505                 510         


Gly Tyr Thr Gly Asn Gly Thr Thr Cys Lys Ala Phe Cys Lys Asp Gly 
        515                 520                 525             


Cys Arg Asn Gly Gly Ala Cys Ile Ala Ala Asn Val Cys Ala Cys Pro 
    530                 535                 540                 


Gln Gly Phe Thr Gly Pro Ser Cys Glu Thr Asp Ile Asp Glu Cys Ser 
545                 550                 555                 560 


Asp Gly Phe Val Gln Cys Asp Ser Arg Ala Asn Cys Ile Asn Leu Pro 
                565                 570                 575     


Gly Trp Tyr His Cys Glu Cys Arg Asp Gly Tyr His Asp Asn Gly Met 
            580                 585                 590         


Phe Ser Pro Ser Gly Glu Ser Cys Glu Asp Ile Asp Glu Cys Gly Thr 
        595                 600                 605             


Gly Arg His Ser Cys Ala Asn Asp Thr Ile Cys Phe Asn Leu Asp Gly 
    610                 615                 620                 


Gly Tyr Asp Cys Arg Cys Pro His Gly Lys Asn Cys Thr Gly Asp Cys 
625                 630                 635                 640 


Ile His Asp Gly Lys Val Lys His Asn Gly Gln Ile Trp Val Leu Glu 
                645                 650                 655     


Asn Asp Arg Cys Ser Val Cys Ser Cys Gln Asn Gly Phe Val Met Cys 
            660                 665                 670         


Arg Arg Met Val Cys Asp Cys Glu Asn Pro Thr Val Asp Leu Phe Cys 
        675                 680                 685             


Cys Pro Glu Cys Asp Pro Arg Leu Ser Ser Gln Cys Leu His Gln Asn 
    690                 695                 700                 


Gly Glu Thr Leu Tyr Asn Ser Gly Asp Thr Trp Val Gln Asn Cys Gln 
705                 710                 715                 720 


Gln Cys Arg Cys Leu Gln Gly Glu Val Asp Cys Trp Pro Leu Pro Cys 
                725                 730                 735     


Pro Asp Val Glu Cys Glu Phe Ser Ile Leu Pro Glu Asn Glu Cys Cys 
            740                 745                 750         


Pro Arg Cys Val Thr Asp Pro Cys Gln Ala Asp Thr Ile Arg Asn Asp 
        755                 760                 765             


Ile Thr Lys Thr Cys Leu Asp Glu Met Asn Val Val Arg Phe Thr Gly 
    770                 775                 780                 


Ser Ser Trp Ile Lys His Gly Thr Glu Cys Thr Leu Cys Gln Cys Lys 
785                 790                 795                 800 


Asn Gly His Ile Cys Cys Ser Val Asp Pro Gln Cys Leu Gln Glu Leu 
                805                 810                 815     


<210>  1813
<211>  815
<212>  PRT
<213>  Homo sapiens

<400>  1813

Met Glu Thr Gly Leu Gly Ala Pro Leu Phe Lys Ala Trp Leu Leu Ile 
1               5                   10                  15      


Ser Val Trp Gly Leu Gly Val Asp Pro Ser Leu Gln Ile Asp Val Leu 
            20                  25                  30          


Thr Glu Leu Glu Leu Gly Glu Ser Thr Thr Gly Val Arg Gln Val Pro 
        35                  40                  45              


Gly Leu His Asn Gly Thr Lys Ala Phe Leu Phe Gln Asp Thr Pro Arg 
    50                  55                  60                  


Ser Ile Lys Ala Ser Thr Ala Thr Ala Glu Gln Phe Phe Gln Lys Leu 
65                  70                  75                  80  


Arg Asn Lys His Glu Phe Thr Ile Leu Val Thr Leu Lys Gln Thr His 
                85                  90                  95      


Leu Asn Ser Gly Val Ile Leu Ser Ile His His Leu Asp His Arg Tyr 
            100                 105                 110         


Leu Glu Leu Glu Ser Ser Gly His Arg Asn Glu Val Arg Leu His Tyr 
        115                 120                 125             


Arg Ser Gly Ser His Arg Pro His Thr Glu Val Phe Pro Tyr Ile Leu 
    130                 135                 140                 


Ala Asp Asp Lys Trp His Lys Leu Ser Leu Ala Ile Ser Ala Ser His 
145                 150                 155                 160 


Leu Ile Leu His Ile Asp Cys Asn Lys Ile Tyr Glu Arg Val Val Glu 
                165                 170                 175     


Lys Pro Ser Thr Asp Leu Pro Leu Gly Thr Thr Phe Trp Leu Gly Gln 
            180                 185                 190         


Arg Asn Asn Ala His Gly Tyr Phe Lys Gly Ile Met Gln Asp Val Gln 
        195                 200                 205             


Leu Leu Val Met Pro Gln Gly Phe Ile Ala Gln Cys Pro Asp Leu Asn 
    210                 215                 220                 


Arg Thr Cys Pro Thr Cys Asn Asp Phe His Gly Leu Val Gln Lys Ile 
225                 230                 235                 240 


Met Glu Leu Gln Asp Ile Leu Ala Lys Thr Ser Ala Lys Leu Ser Arg 
                245                 250                 255     


Ala Glu Gln Arg Met Asn Arg Leu Asp Gln Cys Tyr Cys Glu Arg Thr 
            260                 265                 270         


Cys Thr Met Lys Gly Thr Thr Tyr Arg Glu Phe Glu Ser Trp Ile Asp 
        275                 280                 285             


Gly Cys Lys Asn Cys Thr Cys Leu Asn Gly Thr Ile Gln Cys Glu Thr 
    290                 295                 300                 


Leu Ile Cys Pro Asn Pro Asp Cys Pro Leu Lys Ser Ala Leu Ala Tyr 
305                 310                 315                 320 


Val Asp Gly Lys Cys Cys Lys Glu Cys Lys Ser Ile Cys Gln Phe Gln 
                325                 330                 335     


Gly Arg Thr Tyr Phe Glu Gly Glu Arg Asn Thr Val Tyr Ser Ser Ser 
            340                 345                 350         


Gly Val Cys Val Leu Tyr Glu Cys Lys Asp Gln Thr Met Lys Leu Val 
        355                 360                 365             


Glu Ser Ser Gly Cys Pro Ala Leu Asp Cys Pro Glu Ser His Gln Ile 
    370                 375                 380                 


Thr Leu Ser His Ser Cys Cys Lys Val Cys Lys Gly Tyr Asp Phe Cys 
385                 390                 395                 400 


Ser Glu Arg His Asn Cys Met Glu Asn Ser Ile Cys Arg Asn Leu Asn 
                405                 410                 415     


Asp Arg Ala Val Cys Ser Cys Arg Asp Gly Phe Arg Ala Leu Arg Glu 
            420                 425                 430         


Asp Asn Ala Tyr Cys Glu Asp Ile Asp Glu Cys Ala Glu Gly Arg His 
        435                 440                 445             


Tyr Cys Arg Glu Asn Thr Met Cys Val Asn Thr Pro Gly Ser Phe Met 
    450                 455                 460                 


Cys Ile Cys Lys Thr Gly Tyr Ile Arg Ile Asp Asp Tyr Ser Cys Thr 
465                 470                 475                 480 


Glu His Asp Glu Cys Ile Thr Asn Gln His Asn Cys Asp Glu Asn Ala 
                485                 490                 495     


Leu Cys Phe Asn Thr Val Gly Gly His Asn Cys Val Cys Lys Pro Gly 
            500                 505                 510         


Tyr Thr Gly Asn Gly Thr Thr Cys Lys Ala Phe Cys Lys Asp Gly Cys 
        515                 520                 525             


Arg Asn Gly Gly Ala Cys Ile Ala Ala Asn Val Cys Ala Cys Pro Gln 
    530                 535                 540                 


Gly Phe Thr Gly Pro Ser Cys Glu Thr Asp Ile Asp Glu Cys Ser Asp 
545                 550                 555                 560 


Gly Phe Val Gln Cys Asp Ser Arg Ala Asn Cys Ile Asn Leu Pro Gly 
                565                 570                 575     


Trp Tyr His Cys Glu Cys Arg Asp Gly Tyr His Asp Asn Gly Met Phe 
            580                 585                 590         


Ser Pro Ser Gly Glu Ser Cys Glu Asp Ile Asp Glu Cys Gly Thr Gly 
        595                 600                 605             


Arg His Ser Cys Ala Asn Asp Thr Ile Cys Phe Asn Leu Asp Gly Gly 
    610                 615                 620                 


Tyr Asp Cys Arg Cys Pro His Gly Lys Asn Cys Thr Gly Asp Cys Ile 
625                 630                 635                 640 


His Asp Gly Lys Val Lys His Asn Gly Gln Ile Trp Val Leu Glu Asn 
                645                 650                 655     


Asp Arg Cys Ser Val Cys Ser Cys Gln Asn Gly Phe Val Met Cys Arg 
            660                 665                 670         


Arg Met Val Cys Asp Cys Glu Asn Pro Thr Val Asp Leu Phe Cys Cys 
        675                 680                 685             


Pro Glu Cys Asp Pro Arg Leu Ser Ser Gln Cys Leu His Gln Asn Gly 
    690                 695                 700                 


Glu Thr Leu Tyr Asn Ser Gly Asp Thr Trp Val Gln Asn Cys Gln Gln 
705                 710                 715                 720 


Cys Arg Cys Leu Gln Gly Glu Val Asp Cys Trp Pro Leu Pro Cys Pro 
                725                 730                 735     


Asp Val Glu Cys Glu Phe Ser Ile Leu Pro Glu Asn Glu Cys Cys Pro 
            740                 745                 750         


Arg Cys Val Thr Asp Pro Cys Gln Ala Asp Thr Ile Arg Asn Asp Ile 
        755                 760                 765             


Thr Lys Thr Cys Leu Asp Glu Met Asn Val Val Arg Phe Thr Gly Ser 
    770                 775                 780                 


Ser Trp Ile Lys His Gly Thr Glu Cys Thr Leu Cys Gln Cys Lys Asn 
785                 790                 795                 800 


Gly His Ile Cys Cys Ser Val Asp Pro Gln Cys Leu Gln Glu Leu 
                805                 810                 815 


<210>  1814
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  1814

Met Ser Ile Arg Arg Leu Leu Ile Leu Ile Leu Lys Ile Gly Arg Arg 
1               5                   10                  15      


Trp Thr Glu Leu Ile Arg Thr Met Glu Ser Arg Val Leu Leu Arg Thr 
            20                  25                  30          


Phe Cys Leu Ile Phe Gly Leu Gly Ala Val Trp Gly Leu Gly Val Asp 
        35                  40                  45              


Pro Ser Leu Gln Ile Asp Val Leu Thr Glu Leu Glu Leu Gly Glu Ser 
    50                  55                  60                  


Thr Thr Gly Val Arg Gln Val Pro Gly Leu His Asn Gly Thr Lys Ala 
65                  70                  75                  80  


Phe Leu Phe Gln Asp Thr Pro Arg Ser Ile Lys Ala Ser Thr Ala Thr 
                85                  90                  95      


Ala Glu Gln Phe Phe Gln Lys Leu Arg Asn Lys His Glu Phe Thr Ile 
            100                 105                 110         


Leu Val Thr Leu Lys Gln Thr His Leu Asn Ser Gly Val Ile Leu Ser 
        115                 120                 125             


Ile His His Leu Asp His Arg Tyr Leu Glu Leu Glu Ser Ser Gly His 
    130                 135                 140                 


Arg Asn Glu Val Arg Leu His Tyr Arg Ser Gly Ser His Arg Pro His 
145                 150                 155                 160 


Thr Glu Val Phe Pro Tyr Ile Leu Ala Asp Asp Lys Trp His Lys Leu 
                165                 170                 175     


Ser Leu Ala Ile Ser Ala Ser His Leu Ile Leu His Ile Asp Cys Asn 
            180                 185                 190         


Lys Ile Tyr Glu Arg Val Val Glu Lys Pro Ser Thr Asp Leu Pro Leu 
        195                 200                 205             


Gly Thr Thr Phe Trp Leu Gly Gln Arg Asn Asn Ala His Gly Tyr Phe 
    210                 215                 220                 


Lys Gly Ile Met Gln Asp Val Gln Leu Leu Val Met Pro Gln Gly Phe 
225                 230                 235                 240 


Ile Ala Gln Cys Pro Asp Leu Asn Arg Thr Cys Pro Thr Cys Asn Asp 
                245                 250                 255     


Phe His Gly Leu Val Gln Lys Ile Met Glu Leu Gln Asp Ile Leu Ala 
            260                 265                 270         


Lys Thr Ser Ala Lys Leu Ser Arg Ala Glu Gln Arg Met Asn Arg Leu 
        275                 280                 285             


Asp Gln Cys Tyr Cys Glu Arg Thr Cys Thr Met Lys Gly Thr Thr Tyr 
    290                 295                 300                 


Arg Glu Phe Glu Ser Trp Ile Asp Gly Cys Lys Asn Cys Thr Cys Leu 
305                 310                 315                 320 


Asn Gly Thr Ile Gln Cys Glu Thr Leu Ile Cys Pro Asn Pro Asp Cys 
                325                 330                 335     


Pro Leu Lys Ser Ala Leu Ala Tyr Val Asp Gly Lys Cys Cys Lys Glu 
            340                 345                 350         


Cys Lys Ser Ile Cys Gln Phe Gln Gly Arg Thr Tyr Phe Glu Gly Glu 
        355                 360                 365             


Arg Asn Thr Val Tyr Ser Ser Ser Gly Val Cys Val Leu Tyr Glu Cys 
    370                 375                 380                 


Lys Asp Gln Thr Met Lys Leu Val Glu Ser Ser Gly Cys Pro Ala Leu 
385                 390                 395                 400 


Asp Cys Pro Glu Ser His Gln Ile Thr Leu Ser His Ser Cys Cys Lys 
                405                 410                 415     


Val Cys Lys Gly Tyr Asp Phe Cys Ser Glu Arg His Asn Cys Met Glu 
            420                 425                 430         


Asn Ser Ile Cys Arg Asn Leu Asn Asp Arg Ala Val Cys Ser Cys Arg 
        435                 440                 445             


Asp Gly Phe Arg Ala Leu Arg Glu Asp Asn Ala Tyr Cys Glu Asp Ile 
    450                 455                 460                 


Asp Glu Cys Ala Glu Gly Arg His Tyr Cys Arg Glu Asn Thr Met Cys 
465                 470                 475                 480 


Val Asn Thr Pro Gly Ser Phe Met Cys Ile Cys Lys Thr Gly Tyr Ile 
                485                 490                 495     


Arg Ile Asp Asp Tyr Ser Cys Thr Glu His Asp Glu Cys Ile Thr Asn 
            500                 505                 510         


Gln His Asn Cys Asp Glu Asn Ala Leu Cys Phe Asn Thr Val Gly Gly 
        515                 520                 525             


His Asn Cys Val Cys Lys Pro Gly Tyr Thr Gly Asn Gly Thr Thr Cys 
    530                 535                 540                 


Lys Ala Phe Cys Lys Asp Gly Cys Arg Asn Gly Gly Ala Cys Ile Ala 
545                 550                 555                 560 


Ala Asn Val Cys Ala Cys Pro Gln Gly Phe Thr Gly Pro Ser Cys Glu 
                565                 570                 575     


Thr Asp Ile Asp Glu Cys Ser Asp Gly Phe Val Gln Cys Asp Ser Arg 
            580                 585                 590         


Ala Asn Cys Ile Asn Leu Pro Gly Trp Tyr His Cys Glu Cys Arg Asp 
        595                 600                 605             


Gly Tyr His Asp Asn Gly Met Phe Ser Pro Ser Gly Glu Ser Cys Glu 
    610                 615                 620                 


Asp Ile Asp Glu Cys Gly Thr Gly Arg His Ser Cys Ala Asn Asp Thr 
625                 630                 635                 640 


Ile Cys Phe Asn Leu Asp Gly Gly Tyr Asp Cys Arg Cys Pro His Gly 
                645                 650                 655     


Lys Asn Cys Thr Gly Asp Cys Ile His Asp Gly Lys Val Lys His Asn 
            660                 665                 670         


Gly Gln Ile Trp Val Leu Glu Asn Asp Arg Cys Ser Val Cys Ser Cys 
        675                 680                 685             


Gln Asn Gly Phe Val Met Cys Arg Arg Met Val Cys Asp Cys Glu Asn 
    690                 695                 700                 


Pro Thr Val Asp Leu Phe Cys Cys Pro Glu Cys Asp Pro Arg Leu Ser 
705                 710                 715                 720 


Ser Gln Cys Leu His Gln Asn Gly Glu Thr Leu Tyr Asn Ser Gly Asp 
                725                 730                 735     


Thr Trp Val Gln Asn Cys Gln Gln Cys Arg Cys Leu Gln Gly Glu Val 
            740                 745                 750         


Asp Cys Trp Pro Leu Pro Cys Pro Asp Val Glu Cys Glu Phe Ser Ile 
        755                 760                 765             


Leu Pro Glu Asn Glu Cys Cys Pro Arg Cys Val Thr Asp Pro Cys Gln 
    770                 775                 780                 


Ala Asp Thr Ile Arg Asn Asp Ile Thr Lys Thr Cys Leu Asp Glu Met 
785                 790                 795                 800 


Asn Val Val Arg Phe Thr Gly Ser Ser Trp Ile Lys His Gly Thr Glu 
                805                 810                 815     


Cys Thr Leu Cys Gln Cys Lys Asn Gly His Ile Cys Cys Ser Val Asp 
            820                 825                 830         


Pro Gln Cys Leu Gln Glu Leu 
        835                 


<210>  1815
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  1815

Met Gly Ser Thr Met Glu Pro Pro Gly Gly Ala Tyr Leu His Leu Gly 
1               5                   10                  15      


Ala Val Thr Ser Pro Val Gly Thr Ala Arg Val Leu Gln Leu Ala Phe 
            20                  25                  30          


Gly Cys Thr Thr Phe Ser Leu Val Ala His Arg Gly Gly Phe Ala Gly 
        35                  40                  45              


Val Gln Gly Thr Phe Cys Met Ala Ala Trp Gly Phe Cys Phe Ala Val 
    50                  55                  60                  


Ser Ala Leu Val Val Ala Cys Glu Phe Thr Arg Leu His Gly Cys Leu 
65                  70                  75                  80  


Arg Leu Ser Trp Gly Asn Phe Thr Ala Ala Phe Ala Met Leu Ala Thr 
                85                  90                  95      


Leu Leu Cys Ala Thr Ala Ala Val Leu Tyr Pro Leu Tyr Phe Ala Arg 
            100                 105                 110         


Arg Glu Cys Ser Pro Glu Pro Ala Gly Cys Ala Ala Arg Asp Phe Arg 
        115                 120                 125             


Leu Ala Ala Ser Val Phe Ala Gly Leu Leu Phe Leu Ala Tyr Ala Val 
    130                 135                 140                 


Glu Val Ala Leu Thr Arg Ala Arg Pro Gly Gln Val Ser Ser Tyr Met 
145                 150                 155                 160 


Ala Thr Val Ser Gly Leu Leu Lys Ile Val Gln Ala Phe Val Ala Cys 
                165                 170                 175     


Ile Ile Phe Gly Ala Leu Val His Asp Ser Arg Tyr Gly Arg Tyr Val 
            180                 185                 190         


Ala Thr Gln Trp Cys Val Ala Val Tyr Ser Leu Cys Phe Leu Ala Thr 
        195                 200                 205             


Val Ala Val Val Ala Leu Ser Val Met Gly His Thr Gly Gly Leu Gly 
    210                 215                 220                 


Cys Pro Phe Asp Arg Leu Val Val Val Tyr Thr Phe Leu Ala Val Leu 
225                 230                 235                 240 


Leu Tyr Leu Ser Ala Ala Val Ile Trp Pro Val Phe Cys Phe Asp Pro 
                245                 250                 255     


Lys Tyr Gly Glu Pro Lys Arg Pro Pro Asn Cys Ala Arg Gly Ser Cys 
            260                 265                 270         


Pro Trp Asp Ser Gln Leu Val Val Ala Ile Phe Thr Tyr Val Asn Leu 
        275                 280                 285             


Leu Leu Tyr Val Val Asp Leu Ala Tyr Ser Gln Arg Ile Arg Phe Val 
    290                 295                 300                 


Pro Ser Leu 
305         


<210>  1816
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  1816

Met Asn Ile Leu Gly Leu Val Val Phe Ala Ile Val Phe Gly Val Ala 
1               5                   10                  15      


Leu Arg Lys Leu Gly Pro Glu Gly Glu Leu Leu Ile Arg Phe Phe Asn 
            20                  25                  30          


Ser Phe Asn Glu Ala Thr Met Val Leu Val Ser Trp Ile Met Trp Tyr 
        35                  40                  45              


Ala Pro Val Gly Ile Met Phe Leu Val Ala Gly Lys Ile Val Glu Met 
    50                  55                  60                  


Glu Asp Val Gly Leu Leu Phe Ala Arg Leu Gly Lys Tyr Ile Leu Cys 
65                  70                  75                  80  


Cys Leu Leu Gly His Ala Ile His Gly Leu Leu Val Leu Pro Leu Ile 
                85                  90                  95      


Tyr Phe Leu Phe Thr Arg Lys Asn Pro Tyr Arg Phe Leu Trp Gly Ile 
            100                 105                 110         


Val Thr Pro Leu Ala Thr Ala Phe Gly Thr Ser Ser Ser Ser Ala Thr 
        115                 120                 125             


Leu Pro Leu Met Met Lys Cys Val Glu Glu Asn Asn Gly Val Ala Lys 
    130                 135                 140                 


His Ile Ser Arg Phe Ile Leu Pro Ile Gly Ala Thr Val Asn Met Asp 
145                 150                 155                 160 


Gly Ala Ala Leu Phe Gln Cys Val Ala Ala Val Phe Ile Ala Gln Leu 
                165                 170                 175     


Ser Gln Gln Ser Leu Asp Phe Val Lys Ile Ile Thr Ile Leu Val Thr 
            180                 185                 190         


Ala Thr Ala Ser Ser Val Gly Ala Ala Gly Ile Pro Ala Gly Gly Val 
        195                 200                 205             


Leu Thr Leu Ala Ile Ile Leu Glu Ala Val Asn Leu Pro Val Asp His 
    210                 215                 220                 


Ile Ser Leu Ile Leu Ala Val Asp Trp Leu Val Asp Arg Ser Cys Thr 
225                 230                 235                 240 


Val Leu Asn Val Glu Gly Asp Ala Leu Gly Ala Gly Leu Leu Gln Asn 
                245                 250                 255     


Tyr Val Asp Arg Thr Glu Ser Arg Ser Thr Glu Pro Glu Leu Ile Gln 
            260                 265                 270         


Val Lys Ser Glu Leu Pro Leu Asp Pro Leu Pro Val Pro Thr Glu Glu 
        275                 280                 285             


Gly Asn Pro Leu Leu Lys His Tyr Arg Gly Pro Ala Gly Asp Ala Thr 
    290                 295                 300                 


Val Ala Ser Glu Lys Glu Ser Val Met 
305                 310             


<210>  1817
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  1817

Met Tyr Ser Thr Thr Tyr Glu Glu Arg Asn Ile Thr Gly Thr Arg Val 
1               5                   10                  15      


Lys Val Pro Val Gly Gln Glu Val Glu Gly Met Asn Ile Leu Gly Leu 
            20                  25                  30          


Val Val Phe Ala Ile Val Phe Gly Val Ala Leu Arg Lys Leu Gly Pro 
        35                  40                  45              


Glu Gly Glu Leu Leu Ile Arg Phe Phe Asn Ser Phe Asn Glu Ala Thr 
    50                  55                  60                  


Met Val Leu Val Ser Trp Ile Met Trp Tyr Ala Pro Val Gly Ile Met 
65                  70                  75                  80  


Phe Leu Val Ala Gly Lys Ile Val Glu Met Glu Asp Val Gly Leu Leu 
                85                  90                  95      


Phe Ala Arg Leu Gly Lys Tyr Ile Leu Cys Cys Leu Leu Gly His Ala 
            100                 105                 110         


Ile His Gly Leu Leu Val Leu Pro Leu Ile Tyr Phe Leu Phe Thr Arg 
        115                 120                 125             


Lys Asn Pro Tyr Arg Phe Leu Trp Gly Ile Val Thr Pro Leu Ala Thr 
    130                 135                 140                 


Ala Phe Gly Thr Ser Ser Ser Ser Ala Thr Leu Pro Leu Met Met Lys 
145                 150                 155                 160 


Cys Val Glu Glu Asn Asn Gly Val Ala Lys His Ile Ser Arg Phe Ile 
                165                 170                 175     


Leu Pro Ile Gly Ala Thr Val Asn Met Asp Gly Ala Ala Leu Phe Gln 
            180                 185                 190         


Cys Val Ala Ala Val Phe Ile Ala Gln Leu Ser Gln Gln Ser Leu Asp 
        195                 200                 205             


Phe Val Lys Ile Ile Thr Ile Leu Val Thr Ala Thr Ala Ser Ser Val 
    210                 215                 220                 


Gly Ala Ala Gly Ile Pro Ala Gly Gly Val Leu Thr Leu Ala Ile Ile 
225                 230                 235                 240 


Leu Glu Ala Val Asn Leu Pro Val Asp His Ile Ser Leu Ile Leu Ala 
                245                 250                 255     


Val Asp Trp Leu Val Asp Arg Ser Cys Thr Val Leu Asn Val Glu Gly 
            260                 265                 270         


Asp Ala Leu Gly Ala Gly Leu Leu Gln Asn Tyr Val Asp Arg Thr Glu 
        275                 280                 285             


Ser Arg Ser Thr Glu Pro Glu Leu Ile Gln Val Lys Ser Glu Leu Pro 
    290                 295                 300                 


Leu Asp Pro Leu Pro Val Pro Thr Glu Glu Gly Asn Pro Leu Leu Lys 
305                 310                 315                 320 


His Tyr Arg Gly Pro Ala Gly Asp Ala Thr Val Ala Ser Glu Lys Glu 
                325                 330                 335     


Ser Val Met 
            


<210>  1818
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  1818

Met Gly Gly His Pro Gln Leu Arg Leu Val Lys Ala Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Asn Pro Val Ser Ala Ser Leu Gln Asp Gln His Cys Glu Ser 
            20                  25                  30          


Leu Ser Leu Ala Ser Asn Ile Ser Gly Leu Gln Cys Asn Ala Ser Val 
        35                  40                  45              


Asp Leu Ile Gly Thr Cys Trp Pro Arg Ser Pro Ala Gly Gln Leu Val 
    50                  55                  60                  


Val Arg Pro Cys Pro Ala Phe Phe Tyr Gly Val Arg Tyr Asn Thr Thr 
65                  70                  75                  80  


Asn Asn Gly Tyr Arg Glu Cys Leu Ala Asn Gly Ser Trp Ala Ala Arg 
                85                  90                  95      


Val Asn Tyr Ser Glu Cys Gln Glu Ile Leu Asn Glu Glu Lys Lys Ser 
            100                 105                 110         


Lys Val His Tyr His Val Ala Val Ile Ile Asn Tyr Leu Gly His Cys 
        115                 120                 125             


Ile Ser Leu Val Ala Leu Leu Val Ala Phe Val Leu Phe Leu Arg Leu 
    130                 135                 140                 


Arg Pro Gly Cys Thr His Trp Gly Asp Gln Ala Asp Gly Ala Leu Glu 
145                 150                 155                 160 


Val Gly Ala Pro Trp Ser Gly Ala Pro Phe Gln Val Arg Arg Ser Ile 
                165                 170                 175     


Arg Cys Leu Arg Asn Ile Ile His Trp Asn Leu Ile Ser Ala Phe Ile 
            180                 185                 190         


Leu Arg Asn Ala Thr Trp Phe Val Val Gln Leu Thr Met Ser Pro Glu 
        195                 200                 205             


Val His Gln Ser Asn Val Gly Trp Cys Arg Leu Val Thr Ala Ala Tyr 
    210                 215                 220                 


Asn Tyr Phe His Val Thr Asn Phe Phe Trp Met Phe Gly Glu Gly Cys 
225                 230                 235                 240 


Tyr Leu His Thr Ala Ile Val Leu Thr Tyr Ser Thr Asp Arg Leu Arg 
                245                 250                 255     


Lys Trp Met Phe Ile Cys Ile Gly Trp Gly Val Pro Phe Pro Ile Ile 
            260                 265                 270         


Val Ala Trp Ala Ile Gly Lys Leu Tyr Tyr Asp Asn Glu Lys Cys Trp 
        275                 280                 285             


Phe Gly Lys Arg Pro Gly Val Tyr Thr Asp Tyr Ile Tyr Gln Gly Pro 
    290                 295                 300                 


Met Ile Leu Val Leu Leu Ile Asn Phe Ile Phe Leu Phe Asn Ile Val 
305                 310                 315                 320 


Arg Ile Leu Met Thr Lys Leu Arg Ala Ser Thr Thr Ser Glu Thr Ile 
                325                 330                 335     


Gln Tyr Arg Lys Ala Val Lys Ala Thr Leu Val Leu Leu Pro Leu Leu 
            340                 345                 350         


Gly Ile Thr Tyr Met Leu Phe Phe Val Asn Pro Gly Glu Asp Glu Val 
        355                 360                 365             


Ser Arg Val Val Phe Ile Tyr Phe Asn Ser Phe Leu Glu Ser Phe Gln 
    370                 375                 380                 


Gly Phe Phe Val Ser Val Phe Tyr Cys Phe Leu Asn Ser Glu Val Arg 
385                 390                 395                 400 


Ser Ala Ile Arg Lys Arg Trp His Arg Trp Gln Asp Lys His Ser Ile 
                405                 410                 415     


Arg Ala Arg Val Ala Arg Ala Met Ser Ile Pro Thr Ser Pro Thr Arg 
            420                 425                 430         


Val Ser Phe His Ser Ile Lys Gln Ser Thr Ala Val 
        435                 440                 


<210>  1819
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  1819

Met Gly Gly His Pro Gln Leu Arg Leu Val Lys Ala Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Asn Pro Val Ser Ala Ser Leu Gln Asp Gln His Cys Glu Ser 
            20                  25                  30          


Leu Ser Leu Ala Ser Asn Ile Ser Asp Asn Gly Tyr Arg Glu Cys Leu 
        35                  40                  45              


Ala Asn Gly Ser Trp Ala Ala Arg Val Asn Tyr Ser Glu Cys Gln Glu 
    50                  55                  60                  


Ile Leu Asn Glu Glu Lys Lys Ser Lys Val His Tyr His Val Ala Val 
65                  70                  75                  80  


Ile Ile Asn Tyr Leu Gly His Cys Ile Ser Leu Val Ala Leu Leu Val 
                85                  90                  95      


Ala Phe Val Leu Phe Leu Arg Leu Arg Ser Ile Arg Cys Leu Arg Asn 
            100                 105                 110         


Ile Ile His Trp Asn Leu Ile Ser Ala Phe Ile Leu Arg Asn Ala Thr 
        115                 120                 125             


Trp Phe Val Val Gln Leu Thr Met Ser Pro Glu Val His Gln Ser Asn 
    130                 135                 140                 


Val Gly Trp Cys Arg Leu Val Thr Ala Ala Tyr Asn Tyr Phe His Val 
145                 150                 155                 160 


Thr Asn Phe Phe Trp Met Phe Gly Glu Gly Cys Tyr Leu His Thr Ala 
                165                 170                 175     


Ile Val Leu Thr Tyr Ser Thr Asp Arg Leu Arg Lys Trp Met Phe Ile 
            180                 185                 190         


Cys Ile Gly Trp Gly Val Pro Phe Pro Ile Ile Val Ala Trp Ala Ile 
        195                 200                 205             


Gly Lys Leu Tyr Tyr Asp Asn Glu Lys Cys Trp Phe Gly Lys Arg Pro 
    210                 215                 220                 


Gly Val Tyr Thr Asp Tyr Ile Tyr Gln Gly Pro Met Ile Leu Val Leu 
225                 230                 235                 240 


Leu Ile Asn Phe Ile Phe Leu Phe Asn Ile Val Arg Ile Leu Met Thr 
                245                 250                 255     


Lys Leu Arg Ala Ser Thr Thr Ser Glu Thr Ile Gln Tyr Arg Lys Ala 
            260                 265                 270         


Val Lys Ala Thr Leu Val Leu Leu Pro Leu Leu Gly Ile Thr Tyr Met 
        275                 280                 285             


Leu Phe Phe Val Asn Pro Gly Glu Asp Glu Val Ser Arg Val Val Phe 
    290                 295                 300                 


Ile Tyr Phe Asn Ser Phe Leu Glu Ser Phe Gln Gly Phe Phe Val Ser 
305                 310                 315                 320 


Val Phe Tyr Cys Phe Leu Asn Ser Glu Val Arg Ser Ala Ile Arg Lys 
                325                 330                 335     


Arg Trp His Arg Trp Gln Asp Lys His Ser Ile Arg Ala Arg Val Ala 
            340                 345                 350         


Arg Ala Met Ser Ile Pro Thr Ser Pro Thr Arg Val Ser Phe His Ser 
        355                 360                 365             


Ile Lys Gln Ser Thr Ala Val 
    370                 375 


<210>  1820
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  1820

Met Gly Gly His Pro Gln Leu Arg Leu Val Lys Ala Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Asn Pro Val Ser Ala Ser Leu Gln Asp Gln His Cys Glu Ser 
            20                  25                  30          


Leu Ser Leu Ala Ser Asn Ile Ser Gly Leu Gln Cys Asn Ala Ser Val 
        35                  40                  45              


Asp Leu Ile Gly Thr Cys Trp Pro Arg Ser Pro Ala Gly Gln Leu Val 
    50                  55                  60                  


Val Arg Pro Cys Pro Ala Phe Phe Tyr Gly Val Arg Tyr Asn Thr Thr 
65                  70                  75                  80  


Asn Asn Gly Tyr Arg Glu Cys Leu Ala Asn Gly Ser Trp Ala Ala Arg 
                85                  90                  95      


Val Asn Tyr Ser Glu Cys Gln Glu Ile Leu Asn Glu Glu Lys Lys Ser 
            100                 105                 110         


Lys Val His Tyr His Val Ala Val Ile Ile Asn Tyr Leu Gly His Cys 
        115                 120                 125             


Ile Ser Leu Val Ala Leu Leu Val Ala Phe Val Leu Phe Leu Arg Leu 
    130                 135                 140                 


Arg Ser Ile Arg Cys Leu Arg Asn Ile Ile His Trp Asn Leu Ile Ser 
145                 150                 155                 160 


Ala Phe Ile Leu Arg Asn Ala Thr Trp Phe Val Val Gln Leu Thr Met 
                165                 170                 175     


Ser Pro Glu Val His Gln Ser Asn Val Gly Trp Cys Arg Leu Val Thr 
            180                 185                 190         


Ala Ala Tyr Asn Tyr Phe His Val Thr Asn Phe Phe Trp Met Phe Gly 
        195                 200                 205             


Glu Gly Cys Tyr Leu His Thr Ala Ile Val Leu Thr Tyr Ser Thr Asp 
    210                 215                 220                 


Arg Leu Arg Lys Trp Met Phe Ile Cys Ile Gly Trp Gly Val Pro Phe 
225                 230                 235                 240 


Pro Ile Ile Val Ala Trp Ala Ile Gly Lys Leu Tyr Tyr Asp Asn Glu 
                245                 250                 255     


Lys Cys Trp Phe Gly Lys Arg Pro Gly Val Tyr Thr Asp Tyr Ile Tyr 
            260                 265                 270         


Gln Gly Pro Met Ile Leu Val Leu Leu Ile Asn Phe Ile Phe Leu Phe 
        275                 280                 285             


Asn Ile Val Arg Ile Leu Met Thr Lys Leu Arg Ala Ser Thr Thr Ser 
    290                 295                 300                 


Glu Thr Ile Gln Tyr Arg Lys Ala Val Lys Ala Thr Leu Val Leu Leu 
305                 310                 315                 320 


Pro Leu Leu Gly Ile Thr Tyr Met Leu Phe Phe Val Asn Pro Gly Glu 
                325                 330                 335     


Asp Glu Val Ser Arg Val Val Phe Ile Tyr Phe Asn Ser Phe Leu Glu 
            340                 345                 350         


Ser Phe Gln Val Arg Ser Ala Ile Arg Lys Arg Trp His Arg Trp Gln 
        355                 360                 365             


Asp Lys His Ser Ile Arg Ala Arg Val Ala Arg Ala Met Ser Ile Pro 
    370                 375                 380                 


Thr Ser Pro Thr Arg Val Ser Phe His Ser Ile Lys Gln Ser Thr Ala 
385                 390                 395                 400 


Val 
    


<210>  1821
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  1821

Met Ala Ile Leu Phe Ala Val Val Ala Arg Gly Thr Thr Ile Leu Ala 
1               5                   10                  15      


Lys His Ala Trp Cys Gly Gly Asn Phe Leu Glu Asp Phe Glu Arg Ser 
            20                  25                  30          


Arg Ala Phe Asn Phe Leu Asn Glu Ile Lys Lys Arg Phe Gln Thr Thr 
        35                  40                  45              


Tyr Gly Ser Arg Ala Gln Thr Ala Leu Pro Tyr Ala Met Asn Ser Glu 
    50                  55                  60                  


Phe Ser Ser Val Leu Ala Ala Gln Leu Lys His His Ser Glu Asn Lys 
65                  70                  75                  80  


Gly Leu Asp Lys Val Met Glu Thr Gln Ala Gln Val Asp Glu Leu Lys 
                85                  90                  95      


Gly Ile Met Val Arg Asn Ile Asp Leu Val Ala Gln Arg Gly Glu Arg 
            100                 105                 110         


Leu Glu Leu Leu Ile Asp Lys Thr Glu Asn Leu Val Asp Ser Ser Val 
        115                 120                 125             


Thr Phe Lys Thr Thr Ser Arg Asn Leu Ala Arg Ala Met Cys Met Lys 
    130                 135                 140                 


Asn Leu Lys Leu Thr Ile Ile Ile Ile Ile Val Ser Ile Val Phe Ile 
145                 150                 155                 160 


Tyr Ile Ile Val Ser Pro Leu Cys Gly Gly Phe Thr Trp Pro Ser Cys 
                165                 170                 175     


Val Lys Lys 
            


<210>  1822
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  1822

Met Tyr Arg Ile Ser Gln Leu Met Ser Thr Pro Val Ala Ser Ser Ser 
1               5                   10                  15      


Arg Leu Glu Arg Glu Tyr Ala Gly Glu Leu Ser Pro Thr Cys Ile Phe 
            20                  25                  30          


Pro Ser Phe Thr Cys Asp Ser Leu Asp Gly Tyr His Ser Phe Glu Cys 
        35                  40                  45              


Gly Ser Ile Asp Pro Leu Thr Gly Ser His Tyr Thr Cys Arg Arg Ser 
    50                  55                  60                  


Pro Arg Leu Leu Thr Asn Gly Tyr Tyr Ile Trp Thr Glu Asp Ser Phe 
65                  70                  75                  80  


Leu Cys Asp Lys Asp Gly Asn Ile Thr Leu Asn Pro Ser Gln Thr Ser 
                85                  90                  95      


Val Met Tyr Lys Glu Asn Leu Val Arg Ile Phe Arg Lys Lys Lys Arg 
            100                 105                 110         


Ile Cys His Ser Phe Ser Ser Leu Phe Asn Leu Ser Thr Ser Lys Ser 
        115                 120                 125             


Trp Leu His Gly Ser Ile Phe Gly Asp Ile Asn Ser Ser Pro Ser Glu 
    130                 135                 140                 


Asp Asn Trp Leu Lys Gly Thr Arg Arg Leu Asp Thr Asp His Cys Asn 
145                 150                 155                 160 


Gly Asn Glu Thr Arg Leu Leu Gln Glu Val Phe Phe Gln Ala Ile Leu 
                165                 170                 175     


Leu Ala Val Cys Leu Ile Ile Ser Ala Cys Ala Arg Trp Phe Met Gly 
            180                 185                 190         


Glu Ile Leu Ala Ser Val Phe Thr Cys Ser Leu Met Ile Thr Val Ala 
        195                 200                 205             


Tyr Val Lys Ser Leu Phe Leu Ser Leu Ala Ser Tyr Phe Lys Thr Thr 
    210                 215                 220                 


Ala Cys Ala Arg Phe Val Lys Ile 
225                 230         


<210>  1823
<211>  642
<212>  PRT
<213>  Homo sapiens

<400>  1823

Met Ala Arg His Arg Asn Val Arg Gly Tyr Asn Tyr Asp Glu Asp Phe 
1               5                   10                  15      


Glu Asp Asp Asp Leu Tyr Gly Gln Ser Val Glu Asp Asp Tyr Cys Ile 
            20                  25                  30          


Ser Pro Ser Thr Ala Arg Leu Tyr Ser Cys Leu Asp His Met Arg Glu 
        35                  40                  45              


Val Leu Gly Asp Ala Val Pro Asp Glu Ile Leu Ile Glu Ala Val Leu 
    50                  55                  60                  


Lys Asn Lys Phe Asp Val Gln Lys Ala Leu Ser Gly Val Leu Glu Gln 
65                  70                  75                  80  


Asp Arg Val Gln Ser Leu Lys Asp Lys Asn Glu Ala Thr Val Ser Thr 
                85                  90                  95      


Gly Lys Ile Ala Lys Gly Lys Pro Val Asp Ser Gln Thr Ser Arg Ser 
            100                 105                 110         


Glu Ser Glu Ile Val Pro Lys Val Ala Lys Met Thr Val Ser Gly Lys 
        115                 120                 125             


Lys Gln Thr Met Gly Phe Glu Val Pro Gly Val Ser Ser Glu Glu Asn 
    130                 135                 140                 


Gly His Ser Phe His Thr Pro Gln Lys Gly Pro Pro Ile Glu Asp Ala 
145                 150                 155                 160 


Ile Ala Ser Ser Asp Val Leu Glu Thr Ala Ser Lys Ser Ala Asn Pro 
                165                 170                 175     


Pro His Thr Ile Gln Ala Ser Glu Glu Gln Ser Ser Thr Pro Ala Pro 
            180                 185                 190         


Val Lys Lys Ser Gly Lys Leu Arg Gln Gln Ile Asp Val Lys Ala Glu 
        195                 200                 205             


Leu Glu Lys Arg Gln Gly Gly Lys Gln Leu Leu Asn Leu Val Val Ile 
    210                 215                 220                 


Gly His Val Asp Ala Gly Lys Ser Thr Leu Met Gly His Met Leu Tyr 
225                 230                 235                 240 


Leu Leu Gly Asn Ile Asn Lys Arg Thr Met His Lys Tyr Glu Gln Glu 
                245                 250                 255     


Ser Lys Lys Ala Gly Lys Ala Ser Phe Ala Tyr Ala Trp Val Leu Asp 
            260                 265                 270         


Glu Thr Gly Glu Glu Arg Glu Arg Gly Val Thr Met Asp Val Gly Met 
        275                 280                 285             


Thr Lys Phe Glu Thr Thr Thr Lys Val Ile Thr Leu Met Asp Ala Pro 
    290                 295                 300                 


Gly His Lys Asp Phe Ile Pro Asn Met Ile Thr Gly Ala Ala Gln Ala 
305                 310                 315                 320 


Asp Val Ala Val Leu Val Val Asp Ala Ser Arg Gly Glu Phe Glu Ala 
                325                 330                 335     


Gly Phe Glu Thr Gly Gly Gln Thr Arg Glu His Gly Leu Leu Val Arg 
            340                 345                 350         


Ser Leu Gly Val Thr Gln Leu Ala Val Ala Val Asn Lys Met Asp Gln 
        355                 360                 365             


Val Asn Trp Gln Gln Glu Arg Phe Gln Glu Ile Thr Gly Lys Leu Gly 
    370                 375                 380                 


His Phe Leu Lys Gln Ala Gly Phe Lys Glu Ser Asp Val Gly Phe Ile 
385                 390                 395                 400 


Pro Thr Ser Gly Leu Ser Gly Glu Asn Leu Ile Thr Arg Ser Gln Ser 
                405                 410                 415     


Ser Glu Leu Thr Lys Trp Tyr Lys Gly Leu Cys Leu Leu Glu Gln Ile 
            420                 425                 430         


Asp Ser Phe Lys Pro Pro Gln Arg Ser Ile Asp Lys Pro Phe Arg Leu 
        435                 440                 445             


Cys Val Ser Asp Val Phe Lys Asp Gln Gly Ser Gly Phe Cys Ile Thr 
    450                 455                 460                 


Gly Lys Ile Glu Ala Gly Tyr Ile Gln Thr Gly Asp Arg Leu Leu Ala 
465                 470                 475                 480 


Met Pro Pro Asn Glu Thr Cys Thr Val Lys Gly Ile Thr Leu His Asp 
                485                 490                 495     


Glu Pro Val Asp Trp Ala Ala Ala Gly Asp His Val Ser Leu Thr Leu 
            500                 505                 510         


Val Gly Met Asp Ile Ile Lys Ile Asn Val Gly Cys Ile Phe Cys Gly 
        515                 520                 525             


Pro Lys Val Pro Ile Lys Ala Cys Thr Arg Phe Arg Ala Arg Ile Leu 
    530                 535                 540                 


Ile Phe Asn Ile Glu Ile Pro Ile Thr Lys Gly Phe Pro Val Leu Leu 
545                 550                 555                 560 


His Tyr Gln Thr Val Ser Glu Pro Ala Val Ile Lys Arg Leu Ile Ser 
                565                 570                 575     


Val Leu Asn Lys Ser Thr Gly Glu Val Thr Lys Lys Lys Pro Lys Phe 
            580                 585                 590         


Leu Thr Lys Gly Gln Asn Ala Leu Val Glu Leu Gln Thr Gln Arg Pro 
        595                 600                 605             


Ile Ala Leu Glu Leu Tyr Lys Asp Phe Lys Glu Leu Gly Arg Phe Met 
    610                 615                 620                 


Leu Arg Tyr Gly Gly Ser Thr Ile Ala Ala Gly Val Val Thr Glu Ile 
625                 630                 635                 640 


Lys Glu 
        


<210>  1824
<211>  1079
<212>  PRT
<213>  Homo sapiens

<400>  1824

Met Val Cys Ser Ala Ala Pro Leu Leu Leu Leu Ala Thr Thr Leu Pro 
1               5                   10                  15      


Leu Leu Gly Ser Pro Val Ala Gln Ala Ser Gln Pro Val Ser Glu Thr 
            20                  25                  30          


Gly Val Arg Pro Arg Glu Gly Leu Gln Arg Arg Gln Trp Gly Pro Leu 
        35                  40                  45              


Ile Gly Arg Asp Lys Ala Trp Asn Glu Arg Ile Asp Arg Pro Phe Pro 
    50                  55                  60                  


Ala Cys Pro Ile Pro Leu Ser Ser Ser Phe Gly Arg Trp Pro Lys Gly 
65                  70                  75                  80  


Gln Thr Met Trp Ala Gln Thr Ser Thr Leu Thr Leu Thr Glu Glu Glu 
                85                  90                  95      


Leu Gly Gln Ser Gln Ala Gly Gly Glu Ser Gly Ser Gly Gln Leu Leu 
            100                 105                 110         


Asp Gln Glu Asn Gly Ala Gly Glu Ser Ala Leu Val Ser Val Tyr Val 
        115                 120                 125             


His Leu Asp Phe Pro Asp Lys Thr Trp Pro Pro Glu Leu Ser Arg Thr 
    130                 135                 140                 


Leu Thr Leu Pro Ala Ala Ser Ala Ser Ser Ser Pro Arg Pro Leu Leu 
145                 150                 155                 160 


Thr Gly Leu Arg Leu Thr Thr Glu Cys Asn Val Asn His Lys Gly Asn 
                165                 170                 175     


Phe Tyr Cys Ala Cys Leu Ser Gly Tyr Gln Trp Asn Thr Ser Ile Cys 
            180                 185                 190         


Leu His Tyr Pro Pro Cys Gln Ser Leu His Asn His Gln Pro Cys Gly 
        195                 200                 205             


Cys Leu Val Phe Ser His Pro Glu Pro Gly Tyr Cys Gln Leu Leu Pro 
    210                 215                 220                 


Pro Gly Ser Pro Val Thr Cys Leu Pro Ala Val Pro Gly Ile Leu Asn 
225                 230                 235                 240 


Leu Asn Ser Gln Leu Gln Met Pro Gly Asp Thr Leu Ser Leu Thr Leu 
                245                 250                 255     


His Leu Ser Gln Glu Ala Thr Asn Leu Ser Trp Phe Leu Arg His Pro 
            260                 265                 270         


Gly Ser Pro Ser Pro Ile Leu Leu Gln Pro Gly Thr Gln Val Ser Val 
        275                 280                 285             


Thr Ser Ser His Gly Gln Ala Ala Leu Ser Val Ser Asn Met Ser His 
    290                 295                 300                 


His Trp Ala Gly Glu Tyr Met Ser Cys Phe Glu Ala Gln Gly Phe Lys 
305                 310                 315                 320 


Trp Asn Leu Tyr Glu Val Val Arg Val Pro Leu Lys Ala Thr Asp Val 
                325                 330                 335     


Ala Arg Leu Pro Tyr Gln Leu Ser Ile Ser Cys Ala Thr Ser Pro Gly 
            340                 345                 350         


Phe Gln Leu Ser Cys Cys Ile Pro Ser Thr Asn Leu Ala Tyr Thr Ala 
        355                 360                 365             


Ala Trp Ser Pro Gly Glu Gly Ser Lys Ala Ser Ser Phe Asn Glu Ser 
    370                 375                 380                 


Gly Ser Gln Cys Phe Val Leu Ala Val Gln Arg Cys Pro Met Ala Asp 
385                 390                 395                 400 


Thr Thr Tyr Ala Cys Asp Leu Gln Ser Leu Gly Leu Ala Pro Leu Arg 
                405                 410                 415     


Val Pro Ile Ser Ile Thr Ile Ile Gln Asp Gly Asp Ile Thr Cys Pro 
            420                 425                 430         


Glu Asp Ala Ser Val Leu Thr Trp Asn Val Thr Lys Ala Gly His Val 
        435                 440                 445             


Ala Gln Ala Pro Cys Pro Glu Ser Lys Arg Gly Ile Val Arg Arg Leu 
    450                 455                 460                 


Cys Gly Ala Asp Gly Val Trp Gly Pro Val His Ser Ser Cys Thr Asp 
465                 470                 475                 480 


Ala Arg Leu Leu Ala Leu Phe Thr Arg Thr Lys Leu Leu Gln Ala Gly 
                485                 490                 495     


Gln Gly Ser Pro Ala Glu Glu Val Pro Gln Ile Leu Ala Gln Leu Pro 
            500                 505                 510         


Gly Gln Ala Ala Glu Ala Ser Ser Pro Ser Asp Leu Leu Thr Leu Leu 
        515                 520                 525             


Ser Thr Met Lys Tyr Val Ala Lys Val Val Ala Glu Ala Arg Ile Gln 
    530                 535                 540                 


Leu Asp Arg Arg Ala Leu Lys Asn Leu Leu Ile Ala Thr Asp Lys Val 
545                 550                 555                 560 


Leu Asp Met Asp Thr Arg Ser Leu Trp Thr Leu Ala Gln Ala Arg Lys 
                565                 570                 575     


Pro Trp Ala Gly Ser Thr Leu Leu Leu Ala Val Glu Thr Leu Ala Cys 
            580                 585                 590         


Ser Leu Cys Pro Gln Asp His Pro Phe Ala Phe Ser Leu Pro Asn Val 
        595                 600                 605             


Leu Leu Gln Ser Gln Leu Phe Gly Pro Thr Phe Pro Ala Asp Tyr Ser 
    610                 615                 620                 


Ile Ser Phe Pro Thr Arg Pro Pro Leu Gln Ala Gln Ile Pro Arg His 
625                 630                 635                 640 


Ser Leu Ala Pro Leu Val Arg Asn Gly Thr Glu Ile Ser Ile Thr Ser 
                645                 650                 655     


Leu Val Leu Arg Lys Leu Asp His Leu Leu Pro Ser Asn Tyr Gly Gln 
            660                 665                 670         


Gly Leu Gly Asp Ser Leu Tyr Ala Thr Pro Gly Leu Val Leu Val Ile 
        675                 680                 685             


Ser Ile Met Ala Gly Asp Arg Ala Phe Ser Gln Gly Glu Val Ile Met 
    690                 695                 700                 


Asp Phe Gly Asn Thr Asp Gly Ser Pro His Cys Val Phe Trp Asp His 
705                 710                 715                 720 


Ser Leu Phe Gln Gly Arg Gly Gly Trp Ser Lys Glu Gly Cys Gln Ala 
                725                 730                 735     


Gln Val Ala Ser Ala Ser Pro Thr Ala Gln Cys Leu Cys Gln His Leu 
            740                 745                 750         


Thr Ala Phe Ser Val Leu Met Ser Pro His Thr Val Pro Glu Glu Pro 
        755                 760                 765             


Ala Leu Ala Leu Leu Thr Gln Val Gly Leu Gly Ala Ser Ile Leu Ala 
    770                 775                 780                 


Leu Leu Val Cys Leu Gly Val Tyr Trp Leu Val Trp Arg Val Val Val 
785                 790                 795                 800 


Arg Asn Lys Ile Ser Tyr Phe Arg His Ala Ala Leu Leu Asn Met Val 
                805                 810                 815     


Phe Cys Leu Leu Ala Ala Asp Thr Cys Phe Leu Gly Ala Pro Phe Leu 
            820                 825                 830         


Ser Pro Gly Pro Arg Ser Pro Leu Cys Leu Ala Ala Ala Phe Leu Cys 
        835                 840                 845             


His Phe Leu Tyr Leu Ala Thr Phe Phe Trp Met Leu Ala Gln Ala Leu 
    850                 855                 860                 


Val Leu Ala His Gln Leu Leu Phe Val Phe His Gln Leu Ala Lys His 
865                 870                 875                 880 


Arg Val Leu Pro Leu Met Val Leu Leu Gly Tyr Leu Cys Pro Leu Gly 
                885                 890                 895     


Leu Ala Gly Val Thr Leu Gly Leu Tyr Leu Pro Gln Gly Gln Tyr Leu 
            900                 905                 910         


Arg Glu Gly Glu Cys Trp Leu Asp Gly Lys Gly Gly Ala Leu Tyr Thr 
        915                 920                 925             


Phe Val Gly Pro Val Leu Ala Ile Ile Gly Val Asn Gly Leu Val Leu 
    930                 935                 940                 


Ala Met Ala Met Leu Lys Leu Leu Arg Pro Ser Leu Ser Glu Gly Pro 
945                 950                 955                 960 


Pro Ala Glu Lys Arg Gln Ala Leu Leu Gly Val Ile Lys Ala Leu Leu 
                965                 970                 975     


Ile Leu Thr Pro Ile Phe Gly Leu Thr Trp Gly Leu Gly Leu Ala Thr 
            980                 985                 990         


Leu Leu Glu Glu Val Ser Thr Val  Pro His Tyr Ile Phe  Thr Ile Leu 
        995                 1000                 1005             


Asn Thr  Leu Gln Gly Val Phe  Ile Leu Leu Phe Gly  Cys Leu Met 
    1010                 1015                 1020             


Asp Arg  Lys Ile Gln Glu Ala  Leu Arg Lys Arg Phe  Cys Arg Ala 
    1025                 1030                 1035             


Gln Ala  Pro Ser Ser Thr Ile  Ser Leu Val Ser Cys  Cys Leu Gln 
    1040                 1045                 1050             


Ile Leu  Ser Cys Ala Ser Lys  Ser Met Ser Glu Gly  Ile Pro Trp 
    1055                 1060                 1065             


Pro Ser  Ser Glu Asp Met Gly  Thr Ala Arg Ser 
    1070                 1075                 


<210>  1825
<211>  997
<212>  PRT
<213>  Homo sapiens

<400>  1825

Met Val Cys Ser Ala Ala Pro Leu Leu Leu Leu Ala Thr Thr Leu Pro 
1               5                   10                  15      


Leu Leu Gly Ser Pro Val Ala Gln Ala Ser Gln Pro Gly Gln Ser Gln 
            20                  25                  30          


Ala Gly Gly Glu Ser Gly Ser Gly Gln Leu Leu Asp Gln Glu Asn Gly 
        35                  40                  45              


Ala Gly Glu Ser Ala Leu Val Ser Val Tyr Val His Leu Asp Phe Pro 
    50                  55                  60                  


Asp Lys Thr Trp Pro Pro Glu Leu Ser Arg Thr Leu Thr Leu Pro Ala 
65                  70                  75                  80  


Ala Ser Ala Ser Ser Ser Pro Arg Pro Leu Leu Thr Gly Leu Arg Leu 
                85                  90                  95      


Thr Thr Glu Cys Asn Val Asn His Lys Gly Asn Phe Tyr Cys Ala Cys 
            100                 105                 110         


Leu Ser Gly Tyr Gln Trp Asn Thr Ser Ile Cys Leu His Tyr Pro Pro 
        115                 120                 125             


Cys Gln Ser Leu His Asn His Gln Pro Cys Gly Cys Leu Val Phe Ser 
    130                 135                 140                 


His Pro Glu Pro Gly Tyr Cys Gln Leu Leu Pro Pro Gly Ser Pro Val 
145                 150                 155                 160 


Thr Cys Leu Pro Ala Val Pro Gly Ile Leu Asn Leu Asn Ser Gln Leu 
                165                 170                 175     


Gln Met Pro Gly Asp Thr Leu Ser Leu Thr Leu His Leu Ser Gln Glu 
            180                 185                 190         


Ala Thr Asn Leu Ser Trp Phe Leu Arg His Pro Gly Ser Pro Ser Pro 
        195                 200                 205             


Ile Leu Leu Gln Pro Gly Thr Gln Val Ser Val Thr Ser Ser His Gly 
    210                 215                 220                 


Gln Ala Ala Leu Ser Val Ser Asn Met Ser His His Trp Ala Gly Glu 
225                 230                 235                 240 


Tyr Met Ser Cys Phe Glu Ala Gln Gly Phe Lys Trp Asn Leu Tyr Glu 
                245                 250                 255     


Val Val Arg Val Pro Leu Lys Ala Thr Asp Val Ala Arg Leu Pro Tyr 
            260                 265                 270         


Gln Leu Ser Ile Ser Cys Ala Thr Ser Pro Gly Phe Gln Leu Ser Cys 
        275                 280                 285             


Cys Ile Pro Ser Thr Asn Leu Ala Tyr Thr Ala Ala Trp Ser Pro Gly 
    290                 295                 300                 


Glu Gly Ser Lys Ala Ser Ser Phe Asn Glu Ser Gly Ser Gln Cys Phe 
305                 310                 315                 320 


Val Leu Ala Val Gln Arg Cys Pro Met Ala Asp Thr Thr Tyr Ala Cys 
                325                 330                 335     


Asp Leu Gln Ser Leu Gly Leu Ala Pro Leu Arg Val Pro Ile Ser Ile 
            340                 345                 350         


Thr Ile Ile Gln Asp Gly Asp Ile Thr Cys Pro Glu Asp Ala Ser Val 
        355                 360                 365             


Leu Thr Trp Asn Val Thr Lys Ala Gly His Val Ala Gln Ala Pro Cys 
    370                 375                 380                 


Pro Glu Ser Lys Arg Gly Ile Val Arg Arg Leu Cys Gly Ala Asp Gly 
385                 390                 395                 400 


Val Trp Gly Pro Val His Ser Ser Cys Thr Asp Ala Arg Leu Leu Ala 
                405                 410                 415     


Leu Phe Thr Arg Thr Lys Leu Leu Gln Ala Gly Gln Gly Ser Pro Ala 
            420                 425                 430         


Glu Glu Val Pro Gln Ile Leu Ala Gln Leu Pro Gly Gln Ala Ala Glu 
        435                 440                 445             


Ala Ser Ser Pro Ser Asp Leu Leu Thr Leu Leu Ser Thr Met Lys Tyr 
    450                 455                 460                 


Val Ala Lys Val Val Ala Glu Ala Arg Ile Gln Leu Asp Arg Arg Ala 
465                 470                 475                 480 


Leu Lys Asn Leu Leu Ile Ala Thr Asp Lys Val Leu Asp Met Asp Thr 
                485                 490                 495     


Arg Ser Leu Trp Thr Leu Ala Gln Ala Arg Lys Pro Trp Ala Gly Ser 
            500                 505                 510         


Thr Leu Leu Leu Ala Val Glu Thr Leu Ala Cys Ser Leu Cys Pro Gln 
        515                 520                 525             


Asp His Pro Phe Ala Phe Ser Leu Pro Asn Val Leu Leu Gln Ser Gln 
    530                 535                 540                 


Leu Phe Gly Pro Thr Phe Pro Ala Asp Tyr Ser Ile Ser Phe Pro Thr 
545                 550                 555                 560 


Arg Pro Pro Leu Gln Ala Gln Ile Pro Arg His Ser Leu Ala Pro Leu 
                565                 570                 575     


Val Arg Asn Gly Thr Glu Ile Ser Ile Thr Ser Leu Val Leu Arg Lys 
            580                 585                 590         


Leu Asp His Leu Leu Pro Ser Asn Tyr Gly Gln Gly Leu Gly Asp Ser 
        595                 600                 605             


Leu Tyr Ala Thr Pro Gly Leu Val Leu Val Ile Ser Ile Met Ala Gly 
    610                 615                 620                 


Asp Arg Ala Phe Ser Gln Gly Glu Val Ile Met Asp Phe Gly Asn Thr 
625                 630                 635                 640 


Asp Gly Ser Pro His Cys Val Phe Trp Asp His Ser Leu Phe Gln Gly 
                645                 650                 655     


Arg Gly Gly Trp Ser Lys Glu Gly Cys Gln Ala Gln Val Ala Ser Ala 
            660                 665                 670         


Ser Pro Thr Ala Gln Cys Leu Cys Gln His Leu Thr Ala Phe Ser Val 
        675                 680                 685             


Leu Met Ser Pro His Thr Val Pro Glu Glu Pro Ala Leu Ala Leu Leu 
    690                 695                 700                 


Thr Gln Val Gly Leu Gly Ala Ser Ile Leu Ala Leu Leu Val Cys Leu 
705                 710                 715                 720 


Gly Val Tyr Trp Leu Val Trp Arg Val Val Val Arg Asn Lys Ile Ser 
                725                 730                 735     


Tyr Phe Arg His Ala Ala Leu Leu Asn Met Val Phe Cys Leu Leu Ala 
            740                 745                 750         


Ala Asp Thr Cys Phe Leu Gly Ala Pro Phe Leu Ser Pro Gly Pro Arg 
        755                 760                 765             


Ser Pro Leu Cys Leu Ala Ala Ala Phe Leu Cys His Phe Leu Tyr Leu 
    770                 775                 780                 


Ala Thr Phe Phe Trp Met Leu Ala Gln Ala Leu Val Leu Ala His Gln 
785                 790                 795                 800 


Leu Leu Phe Val Phe His Gln Leu Ala Lys His Arg Val Leu Pro Leu 
                805                 810                 815     


Met Val Leu Leu Gly Tyr Leu Cys Pro Leu Gly Leu Ala Gly Val Thr 
            820                 825                 830         


Leu Gly Leu Tyr Leu Pro Gln Gly Gln Tyr Leu Arg Glu Gly Glu Cys 
        835                 840                 845             


Trp Leu Asp Gly Lys Gly Gly Ala Leu Tyr Thr Phe Val Gly Pro Val 
    850                 855                 860                 


Leu Ala Ile Ile Gly Val Asn Gly Leu Val Leu Ala Met Ala Met Leu 
865                 870                 875                 880 


Lys Leu Leu Arg Pro Ser Leu Ser Glu Gly Pro Pro Ala Glu Lys Arg 
                885                 890                 895     


Gln Ala Leu Leu Gly Val Ile Lys Ala Leu Leu Ile Leu Thr Pro Ile 
            900                 905                 910         


Phe Gly Leu Thr Trp Gly Leu Gly Leu Ala Thr Leu Leu Glu Glu Val 
        915                 920                 925             


Ser Thr Val Pro His Tyr Ile Phe Thr Ile Leu Asn Thr Leu Gln Gly 
    930                 935                 940                 


Val Phe Ile Leu Leu Phe Gly Cys Leu Met Asp Arg Lys Ile Gln Glu 
945                 950                 955                 960 


Ala Leu Arg Lys Arg Phe Cys Arg Ala Gln Ala Pro Ser Ser Thr Ile 
                965                 970                 975     


Ser Leu Ala Thr Asn Glu Gly Cys Ile Leu Glu His Ser Lys Gly Gly 
            980                 985                 990         


Ser Asp Thr Ala Arg 
        995         


<210>  1826
<211>  691
<212>  PRT
<213>  Homo sapiens

<400>  1826

Met Cys Phe Arg Thr Lys Leu Ser Val Ser Trp Val Pro Leu Phe Leu 
1               5                   10                  15      


Leu Leu Ser Arg Val Phe Ser Thr Glu Thr Asp Lys Pro Ser Ala Gln 
            20                  25                  30          


Asp Ser Arg Ser Arg Gly Ser Ser Gly Gln Pro Ala Asp Leu Leu Gln 
        35                  40                  45              


Val Leu Ser Ala Gly Asp His Pro Pro His Asn His Ser Arg Ser Leu 
    50                  55                  60                  


Ile Lys Thr Leu Leu Glu Lys Thr Gly Cys Pro Arg Arg Arg Asn Gly 
65                  70                  75                  80  


Met Gln Gly Asp Cys Asn Leu Cys Phe Glu Pro Asp Ala Leu Leu Leu 
                85                  90                  95      


Ile Ala Gly Gly Asn Phe Glu Asp Gln Leu Arg Glu Glu Val Val Gln 
            100                 105                 110         


Arg Val Ser Leu Leu Leu Leu Tyr Tyr Ile Ile His Gln Glu Glu Ile 
        115                 120                 125             


Cys Ser Ser Lys Leu Asn Met Ser Asn Lys Glu Tyr Lys Phe Tyr Leu 
    130                 135                 140                 


His Ser Leu Leu Ser Leu Arg Gln Asp Glu Asp Ser Ser Phe Leu Ser 
145                 150                 155                 160 


Gln Asn Glu Thr Glu Asp Ile Leu Ala Phe Thr Arg Gln Tyr Phe Asp 
                165                 170                 175     


Thr Ser Gln Ser Gln Cys Met Glu Thr Lys Thr Leu Gln Lys Lys Ser 
            180                 185                 190         


Gly Ile Val Ser Ser Glu Gly Ala Asn Glu Ser Thr Leu Pro Gln Leu 
        195                 200                 205             


Ala Ala Met Ile Ile Thr Leu Ser Leu Gln Gly Val Cys Leu Gly Gln 
    210                 215                 220                 


Gly Asn Leu Pro Ser Pro Asp Tyr Phe Thr Glu Tyr Ile Phe Ser Ser 
225                 230                 235                 240 


Leu Asn Arg Thr Asn Thr Leu Arg Leu Ser Glu Leu Asp Gln Leu Leu 
                245                 250                 255     


Asn Thr Leu Trp Thr Arg Ser Thr Cys Ile Lys Asn Glu Lys Ile His 
            260                 265                 270         


Gln Phe Gln Arg Lys Gln Asn Asn Ile Ile Thr His Asp Gln Asp Tyr 
        275                 280                 285             


Ser Asn Phe Ser Ser Ser Met Glu Lys Glu Ser Glu Asp Gly Pro Val 
    290                 295                 300                 


Ser Trp Asp Gln Thr Cys Phe Ser Ala Arg Gln Leu Val Glu Ile Phe 
305                 310                 315                 320 


Leu Gln Lys Gly Leu Ser Leu Ile Ser Lys Glu Asp Phe Lys Gln Met 
                325                 330                 335     


Ser Pro Gly Ile Ile Gln Gln Leu Leu Ser Cys Ser Cys His Leu Pro 
            340                 345                 350         


Lys Asp Gln Gln Ala Lys Leu Pro Pro Thr Thr Leu Glu Lys Tyr Gly 
        355                 360                 365             


Tyr Ser Thr Val Ala Val Thr Leu Leu Thr Leu Gly Ser Met Leu Gly 
    370                 375                 380                 


Thr Ala Leu Val Leu Phe His Ser Cys Glu Glu Asn Tyr Arg Leu Ile 
385                 390                 395                 400 


Leu Gln Leu Phe Val Gly Leu Ala Val Gly Thr Leu Ser Gly Asp Ala 
                405                 410                 415     


Leu Leu His Leu Ile Pro Gln Val Leu Gly Leu His Lys Gln Glu Ala 
            420                 425                 430         


Pro Glu Phe Gly His Phe His Glu Ser Lys Gly His Ile Trp Lys Leu 
        435                 440                 445             


Met Gly Leu Ile Gly Gly Ile His Gly Phe Phe Leu Ile Glu Lys Cys 
    450                 455                 460                 


Phe Ile Leu Leu Val Ser Pro Asn Asp Lys Gln Gly Leu Ser Leu Val 
465                 470                 475                 480 


Asn Gly His Val Gly His Ser His His Leu Ala Leu Asn Ser Glu Leu 
                485                 490                 495     


Ser Asp Gln Ala Gly Arg Gly Lys Ser Ala Ser Thr Ile Gln Leu Lys 
            500                 505                 510         


Ser Pro Glu Asp Ser Gln Ala Ala Glu Met Pro Ile Gly Ser Met Thr 
        515                 520                 525             


Ala Ser Asn Arg Lys Cys Lys Ala Ile Ser Leu Leu Ala Ile Met Ile 
    530                 535                 540                 


Leu Val Gly Asp Ser Leu His Asn Phe Ala Asp Gly Leu Ala Ile Gly 
545                 550                 555                 560 


Ala Ala Phe Ser Ser Ser Ser Glu Ser Gly Val Thr Thr Thr Ile Ala 
                565                 570                 575     


Ile Leu Cys His Glu Ile Pro His Glu Met Gly Asp Phe Ala Val Leu 
            580                 585                 590         


Leu Ser Ser Gly Leu Ser Met Lys Thr Ala Ile Leu Met Asn Phe Ile 
        595                 600                 605             


Ser Ser Leu Thr Ala Phe Met Gly Leu Tyr Ile Gly Leu Ser Val Ser 
    610                 615                 620                 


Ala Asp Pro Cys Val Gln Asp Trp Ile Phe Thr Val Thr Ala Gly Met 
625                 630                 635                 640 


Phe Leu Tyr Leu Ser Leu Val Glu Met Leu Pro Glu Met Thr His Val 
                645                 650                 655     


Gln Thr Gln Arg Pro Trp Met Met Phe Leu Leu Gln Asn Phe Gly Leu 
            660                 665                 670         


Ile Leu Gly Trp Leu Ser Leu Leu Leu Leu Ala Ile Tyr Glu Gln Asn 
        675                 680                 685             


Ile Lys Ile 
    690     


<210>  1827
<211>  632
<212>  PRT
<213>  Homo sapiens

<400>  1827

Met Ala Arg His Arg Asn Val Arg Gly Tyr Asn Tyr Asp Glu Asp Phe 
1               5                   10                  15      


Glu Asp Asp Asp Leu Tyr Gly Gln Ser Val Glu Asp Asp Tyr Cys Ile 
            20                  25                  30          


Ser Pro Ser Thr Ala Ala Gln Phe Ile Tyr Ser Arg Arg Asp Lys Pro 
        35                  40                  45              


Ser Val Glu Pro Val Glu Glu Tyr Asp Tyr Glu Asp Leu Lys Glu Ser 
    50                  55                  60                  


Ser Asn Ser Val Ser Asn His Gln Leu Ser Gly Phe Asp Gln Ala Arg 
65                  70                  75                  80  


Leu Tyr Ser Cys Leu Asp His Met Arg Glu Val Leu Gly Asp Ala Val 
                85                  90                  95      


Pro Asp Glu Ile Leu Ile Glu Ala Val Leu Lys Asn Lys Phe Asp Val 
            100                 105                 110         


Gln Lys Ala Leu Ser Gly Val Leu Glu Gln Asp Arg Val Gln Ser Leu 
        115                 120                 125             


Lys Asp Lys Asn Glu Ala Thr Val Ser Thr Gly Lys Ile Ala Lys Gly 
    130                 135                 140                 


Val Leu Phe Ser Ser Ser Glu Val Ser Ala Asp Asn Val Gln Ser Ser 
145                 150                 155                 160 


Tyr Pro Gln Ser Ala Asn His Leu Asp Tyr Ser Ser Lys Pro Phe Asp 
                165                 170                 175     


Phe Ala Ser Ser Val Gly Lys Tyr Gly Leu Ser His Asn Ser Ser Val 
            180                 185                 190         


Pro Thr His Cys Leu Leu His Arg Lys Lys Lys Leu Asp Thr Arg Lys 
        195                 200                 205             


Ser Glu Lys Lys Leu Glu Ser Cys Lys Leu Thr Lys Glu Leu Ser Leu 
    210                 215                 220                 


Ala Asn Leu Ile His Asp Met Ser Arg Asp Ser Cys Glu Ser Gln Pro 
225                 230                 235                 240 


Ser Val Arg Leu Ser Ser Thr Asp Ser Leu Glu Ser Leu Leu Ser Lys 
                245                 250                 255     


Asn Leu Asp Ala Asp Leu Leu Arg Pro His Ala Ser Glu Cys Ile Ser 
            260                 265                 270         


Lys Asp Asp Ser Ala Phe Lys Glu Ile Pro Asp Leu Lys Thr Ile Ile 
        275                 280                 285             


Ile Lys Gly Thr Thr Pro Asn Asn Ser Leu Tyr Ile Gln Asn Asn Ser 
    290                 295                 300                 


Leu Ser Asp Phe Gln Asn Ile Pro Val Gln Asp Ser Leu Gly Ser Ser 
305                 310                 315                 320 


Asn Asn Pro Leu Tyr Leu Thr Ser Ser Leu Glu Asn Met Thr Val Asp 
                325                 330                 335     


Asn Leu Asn Ala Ser Lys Glu Thr Glu Val Gly Asn Val Ser Leu Val 
            340                 345                 350         


Glu Gln Ser Ala Lys Asn His Thr Phe Lys Asn Asp Asn Leu Gln Phe 
        355                 360                 365             


Ser Gln Cys Glu Ser Pro Ser Leu Thr Glu Leu Phe Gln Glu His Lys 
    370                 375                 380                 


Glu Asn Asn Ile Ser Gln Cys Phe Thr Leu Ser Asp Leu Cys Asn Gln 
385                 390                 395                 400 


Ser Ser Ala Ser Phe Thr Asp Leu Ser Leu Gly Ser Phe Pro Leu Ser 
                405                 410                 415     


Gln Leu Ala Asn Arg Cys Gln Ser Ser Pro Gly Ile Ser Glu Leu Thr 
            420                 425                 430         


Gly Ser Leu Ser Ser Leu Ala Phe His Lys Ala Ser Pro Thr Arg Asp 
        435                 440                 445             


Leu Glu Asn Leu Ser Leu Ser Glu Leu Ile Ala Glu Thr Ile Asp Val 
    450                 455                 460                 


Asp Asn Ser Gln Ile Lys Lys Glu Ser Phe Glu Val Ser Leu Ser Glu 
465                 470                 475                 480 


Val Arg Ser Pro Gly Ile Asp Ser Asn Ile Asp Leu Ser Val Leu Ile 
                485                 490                 495     


Lys Asn Pro Asp Phe Val Pro Lys Pro Val Val Asp Pro Ser Ile Ala 
            500                 505                 510         


Pro Ser Ser Arg Thr Lys Val Leu Ser Ser Lys Leu Gly Lys Asn Ser 
        515                 520                 525             


Asn Phe Ala Lys Asp Asn Lys Lys Asn Asn Lys Gly Ser Leu Thr Arg 
    530                 535                 540                 


Lys Pro Pro Phe Ser Leu Ser Trp Thr Lys Ala Leu Ala Ala Arg Pro 
545                 550                 555                 560 


Ser Ala Phe Ala Ser Thr Leu Cys Leu Arg Tyr Pro Leu Lys Ser Cys 
                565                 570                 575     


Lys Arg Arg Thr Leu Asp Leu Tyr Lys Thr Phe Leu Tyr Ser Arg Gln 
            580                 585                 590         


Val Gln Asp Val Lys Asp Lys Glu Ile Ser Pro Leu Val Ala Ile Thr 
        595                 600                 605             


Pro Phe Asp Phe Lys Ser Ala Ser Pro Asp Asp Ile Val Lys Ala Asn 
    610                 615                 620                 


Gln Lys Lys Ala Phe Thr Arg Glu 
625                 630         


<210>  1828
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  1828

Met Gly Thr Glu Asn Thr Pro Gly Gly Lys Ala Ser Pro Asp Pro Gln 
1               5                   10                  15      


Asp Val Arg Pro Ser Val Phe His Asn Ile Lys Leu Phe Val Leu Cys 
            20                  25                  30          


His Ser Leu Leu Gln Leu Ala Gln Leu Met Ile Ser Gly Tyr Leu Lys 
        35                  40                  45              


Ser Ser Ile Ser Thr Val Glu Lys Arg Phe Gly Leu Ser Ser Gln Thr 
    50                  55                  60                  


Ser Gly Leu Leu Ala Ser Phe Asn Glu Val Gly Asn Thr Ala Leu Ile 
65                  70                  75                  80  


Val Phe Val Ser Tyr Phe Gly Ser Arg Val His Arg Pro Arg Met Ile 
                85                  90                  95      


Gly Tyr Gly Ala Ile Leu Val Ala Leu Ala Gly Leu Leu Met Thr Leu 
            100                 105                 110         


Pro His Phe Ile Ser Glu Pro Tyr Arg Tyr Asp Asn Thr Ser Pro Glu 
        115                 120                 125             


Asp Met Pro Gln Asp Phe Lys Ala Ser Leu Cys Leu Pro Thr Thr Ser 
    130                 135                 140                 


Ala Pro Ala Ser Ala Pro Ser Asn Gly Asn Cys Ser Ser Tyr Thr Glu 
145                 150                 155                 160 


Thr Gln His Leu Ser Val Val Gly Ile Met Phe Val Ala Gln Thr Leu 
                165                 170                 175     


Leu Gly Val Gly Gly Val Pro Ile Gln Pro Phe Gly Ile Ser Tyr Ile 
            180                 185                 190         


Asp Asp Phe Ala His Asn Ser Asn Ser Pro Leu Tyr Leu Gly Ile Leu 
        195                 200                 205             


Phe Ala Val Thr Met Met Gly Pro Gly Leu Ala Phe Gly Leu Gly Ser 
    210                 215                 220                 


Leu Met Leu Arg Leu Tyr Val Asp Ile Asn Gln Met Pro Glu Gly Gly 
225                 230                 235                 240 


Ile Ser Leu Thr Ile Lys Asp Pro Arg Trp Val Gly Ala Trp Trp Leu 
                245                 250                 255     


Gly Phe Leu Ile Ala Ala Gly Ala Val Ala Leu Ala Ala Ile Pro Tyr 
            260                 265                 270         


Phe Phe Phe Pro Lys Glu Met Pro Lys Glu Lys Arg Glu Leu Gln Phe 
        275                 280                 285             


Arg Arg Lys Val Leu Ala Val Thr Asp Ser Pro Ala Arg Lys Gly Lys 
    290                 295                 300                 


Asp Ser Pro Ser Lys Gln Ser Pro Gly Glu Ser Thr Lys Lys Gln Asp 
305                 310                 315                 320 


Gly Leu Val Gln Ile Ala Pro Asn Leu Thr Val Ile Gln Phe Ile Lys 
                325                 330                 335     


Val Phe Pro Arg Val Leu Leu Gln Thr Leu Arg His Pro Ile Phe Leu 
            340                 345                 350         


Leu Val Val Leu Ser Gln Val Cys Leu Ser Ser Met Ala Ala Gly Met 
        355                 360                 365             


Ala Thr Phe Leu Pro Lys Phe Leu Glu Arg Gln Phe Ser Ile Thr Ala 
    370                 375                 380                 


Ser Tyr Ala Asn Leu Leu Ile Gly Cys Leu Ser Phe Pro Ser Val Ile 
385                 390                 395                 400 


Val Gly Ile Val Val Gly Gly Val Leu Val Lys Arg Leu His Leu Gly 
                405                 410                 415     


Pro Val Gly Cys Gly Ala Leu Cys Leu Leu Gly Met Leu Leu Cys Leu 
            420                 425                 430         


Phe Phe Ser Leu Pro Leu Phe Phe Ile Gly Cys Ser Ser His Gln Ile 
        435                 440                 445             


Ala Gly Ile Thr His Gln Thr Ser Ala His Pro Gly Leu Glu Leu Ser 
    450                 455                 460                 


Pro Ser Cys Met Glu Ala Cys Ser Cys Pro Leu Asp Gly Phe Asn Pro 
465                 470                 475                 480 


Val Cys Asp Pro Ser Thr Arg Val Glu Tyr Ile Thr Pro Cys His Ala 
                485                 490                 495     


Gly Cys Ser Ser Trp Val Val Gln Asp Ala Leu Asp Asn Ser Gln Val 
            500                 505                 510         


Phe Tyr Thr Asn Cys Ser Cys Val Val Glu Gly Asn Pro Val Leu Ala 
        515                 520                 525             


Gly Ser Cys Asp Ser Thr Cys Ser His Leu Val Val Pro Phe Leu Leu 
    530                 535                 540                 


Leu Val Ser Leu Gly Ser Ala Leu Ala Cys Leu Thr His Thr Pro Ser 
545                 550                 555                 560 


Phe Met Leu Ile Leu Arg Gly Val Lys Lys Glu Asp Lys Thr Leu Ala 
                565                 570                 575     


Val Gly Ile Gln Phe Met Phe Leu Arg Ile Leu Ala Trp Met Pro Ser 
            580                 585                 590         


Pro Val Ile His Gly Ser Ala Ile Asp Thr Thr Cys Val His Trp Ala 
        595                 600                 605             


Leu Ser Cys Gly Arg Arg Ala Val Cys Arg Tyr Tyr Asn Asn Asp Leu 
    610                 615                 620                 


Leu Arg Asn Arg Phe Ile Gly Leu Gln Phe Phe Phe Lys Thr Gly Ser 
625                 630                 635                 640 


Val Ile Cys Phe Ala Leu Val Leu Ala Val Leu Arg Gln Gln Asp Lys 
                645                 650                 655     


Glu Ala Arg Thr Lys Glu Ser Arg Ser Ser Pro Ala Val Glu Gln Gln 
            660                 665                 670         


Leu Leu Val Ser Gly Pro Gly Lys Lys Pro Glu Asp Ser Arg Val 
        675                 680                 685         


<210>  1829
<211>  565
<212>  PRT
<213>  Homo sapiens

<400>  1829

Met Gly Pro Arg Ile Glu Asp Met Pro Gln Asp Phe Lys Ala Ser Leu 
1               5                   10                  15      


Cys Leu Pro Thr Thr Ser Ala Pro Ala Ser Ala Pro Ser Asn Gly Asn 
            20                  25                  30          


Cys Ser Ser Tyr Thr Glu Thr Gln His Leu Ser Val Val Gly Ile Met 
        35                  40                  45              


Phe Val Ala Gln Thr Leu Leu Gly Val Gly Gly Val Pro Ile Gln Pro 
    50                  55                  60                  


Phe Gly Ile Ser Tyr Ile Asp Asp Phe Ala His Asn Ser Asn Ser Pro 
65                  70                  75                  80  


Leu Tyr Leu Gly Ile Leu Phe Ala Val Thr Met Met Gly Pro Gly Leu 
                85                  90                  95      


Ala Phe Gly Leu Gly Ser Leu Met Leu Arg Leu Tyr Val Asp Ile Asn 
            100                 105                 110         


Gln Met Pro Glu Gly Gly Ile Ser Leu Thr Ile Lys Asp Pro Arg Trp 
        115                 120                 125             


Val Gly Ala Trp Trp Leu Gly Phe Leu Ile Ala Ala Gly Ala Val Ala 
    130                 135                 140                 


Leu Ala Ala Ile Pro Tyr Phe Phe Phe Pro Lys Glu Met Pro Lys Glu 
145                 150                 155                 160 


Lys Arg Glu Leu Gln Phe Arg Arg Lys Val Leu Ala Val Thr Asp Ser 
                165                 170                 175     


Pro Ala Arg Lys Gly Lys Asp Ser Pro Ser Lys Gln Ser Pro Gly Glu 
            180                 185                 190         


Ser Thr Lys Lys Gln Asp Gly Leu Val Gln Ile Ala Pro Asn Leu Thr 
        195                 200                 205             


Val Ile Gln Phe Ile Lys Val Phe Pro Arg Val Leu Leu Gln Thr Leu 
    210                 215                 220                 


Arg His Pro Ile Phe Leu Leu Val Val Leu Ser Gln Val Cys Leu Ser 
225                 230                 235                 240 


Ser Met Ala Ala Gly Met Ala Thr Phe Leu Pro Lys Phe Leu Glu Arg 
                245                 250                 255     


Gln Phe Ser Ile Thr Ala Ser Tyr Ala Asn Leu Leu Ile Gly Cys Leu 
            260                 265                 270         


Ser Phe Pro Ser Val Ile Val Gly Ile Val Val Gly Gly Val Leu Val 
        275                 280                 285             


Lys Arg Leu His Leu Gly Pro Val Gly Cys Gly Ala Leu Cys Leu Leu 
    290                 295                 300                 


Gly Met Leu Leu Cys Leu Phe Phe Ser Leu Pro Leu Phe Phe Ile Gly 
305                 310                 315                 320 


Cys Ser Ser His Gln Ile Ala Gly Ile Thr His Gln Thr Ser Ala His 
                325                 330                 335     


Pro Gly Leu Glu Leu Ser Pro Ser Cys Met Glu Ala Cys Ser Cys Pro 
            340                 345                 350         


Leu Asp Gly Phe Asn Pro Val Cys Asp Pro Ser Thr Arg Val Glu Tyr 
        355                 360                 365             


Ile Thr Pro Cys His Ala Gly Cys Ser Ser Trp Val Val Gln Asp Ala 
    370                 375                 380                 


Leu Asp Asn Ser Gln Val Phe Tyr Thr Asn Cys Ser Cys Val Val Glu 
385                 390                 395                 400 


Gly Asn Pro Val Leu Ala Gly Ser Cys Asp Ser Thr Cys Ser His Leu 
                405                 410                 415     


Val Val Pro Phe Leu Leu Leu Val Ser Leu Gly Ser Ala Leu Ala Cys 
            420                 425                 430         


Leu Thr His Thr Pro Ser Phe Met Leu Ile Leu Arg Gly Val Lys Lys 
        435                 440                 445             


Glu Asp Lys Thr Leu Ala Val Gly Ile Gln Phe Met Phe Leu Arg Ile 
    450                 455                 460                 


Leu Ala Trp Met Pro Ser Pro Val Ile His Gly Ser Ala Ile Asp Thr 
465                 470                 475                 480 


Thr Cys Val His Trp Ala Leu Ser Cys Gly Arg Arg Ala Val Cys Arg 
                485                 490                 495     


Tyr Tyr Asn Asn Asp Leu Leu Arg Asn Arg Phe Ile Gly Leu Gln Phe 
            500                 505                 510         


Phe Phe Lys Thr Gly Ser Val Ile Cys Phe Ala Leu Val Leu Ala Val 
        515                 520                 525             


Leu Arg Gln Gln Asp Lys Glu Ala Arg Thr Lys Glu Ser Arg Ser Ser 
    530                 535                 540                 


Pro Ala Val Glu Gln Gln Leu Leu Val Ser Gly Pro Gly Lys Lys Pro 
545                 550                 555                 560 


Glu Asp Ser Arg Val 
                565 


<210>  1830
<211>  484
<212>  PRT
<213>  Homo sapiens

<400>  1830

Met Ala Thr Ser Ile Leu Gly Glu Glu Pro Arg Phe Gly Thr Thr Pro 
1               5                   10                  15      


Leu Ala Met Leu Ala Ala Thr Cys Asn Lys Ile Gly Asn Thr Ser Pro 
            20                  25                  30          


Leu Thr Thr Leu Pro Glu Ser Ser Ala Phe Ala Lys Gly Gly Phe His 
        35                  40                  45              


Pro Trp Lys Arg Ser Ser Ser Ser Cys Asn Leu Gly Ser Ser Leu Ser 
    50                  55                  60                  


Gly Phe Ala Val Ala Thr Gly Gly Arg Gly Ser Gly Gly Leu Ala Gly 
65                  70                  75                  80  


Gly Ser Gly Ala Ala Asn Ser Ala Phe Cys Leu Ala Ser Thr Ser Pro 
                85                  90                  95      


Thr Ser Ser Ala Phe Ser Ser Asp Tyr Gly Gly Leu Phe Ser Asn Ser 
            100                 105                 110         


Ala Ala Ala Ala Ala Ala Ala Ala Gly Val Ser Pro Gln Glu Ala Gly 
        115                 120                 125             


Gly Gln Ser Ala Phe Ile Ser Lys Val His Thr Thr Ala Ala Asp Gly 
    130                 135                 140                 


Leu Tyr Pro Arg Val Gly Met Ala His Pro Tyr Glu Ser Trp Tyr Lys 
145                 150                 155                 160 


Ser Gly Phe His Ser Thr Leu Ala Ala Gly Glu Val Thr Asn Gly Ala 
                165                 170                 175     


Ala Ser Ser Trp Trp Asp Val His Ser Ser Pro Gly Ser Trp Leu Glu 
            180                 185                 190         


Val Gln Asn Pro Ala Gly Gly Leu Gln Ser Ser Leu His Ser Gly Ala 
        195                 200                 205             


Pro Gln Ala Ser Leu His Ser Gln Leu Gly Thr Tyr Asn Pro Asp Phe 
    210                 215                 220                 


Ser Ser Leu Thr His Ser Ala Phe Ser Ser Thr Gly Leu Gly Ser Ser 
225                 230                 235                 240 


Ala Ala Ala Ala Ser His Leu Leu Ser Thr Ser Gln His Leu Leu Ala 
                245                 250                 255     


Gln Asp Gly Phe Lys Pro Val Leu Pro Ser Tyr Ser Asp Ser Ser Ala 
            260                 265                 270         


Ala Val Ala Ala Ala Ala Ala Ser Ala Met Ile Ser Gly Ala Ala Ala 
        275                 280                 285             


Ala Ala Ala Gly Gly Ser Ser Ala Arg Ser Ala Arg Arg Tyr Ser Gly 
    290                 295                 300                 


Arg Ala Thr Cys Asp Cys Pro Asn Cys Gln Glu Ala Glu Arg Leu Gly 
305                 310                 315                 320 


Pro Ala Gly Ala Ser Leu Arg Arg Lys Gly Leu His Ser Cys His Ile 
                325                 330                 335     


Pro Gly Cys Gly Lys Val Tyr Gly Lys Thr Ser His Leu Lys Ala His 
            340                 345                 350         


Leu Arg Trp His Thr Gly Glu Arg Pro Phe Val Cys Asn Trp Leu Phe 
        355                 360                 365             


Cys Gly Lys Arg Phe Thr Arg Ser Asp Glu Leu Gln Arg His Leu Arg 
    370                 375                 380                 


Thr His Thr Gly Glu Lys Arg Phe Ala Cys Pro Val Cys Asn Lys Arg 
385                 390                 395                 400 


Phe Met Arg Ser Asp His Leu Ser Lys His Ile Lys Thr His Asn Gly 
                405                 410                 415     


Gly Gly Gly Gly Lys Lys Gly Ser Asp Ser Asp Thr Asp Ala Ser Asn 
            420                 425                 430         


Leu Glu Thr Pro Arg Ser Glu Ser Pro Asp Leu Ile Leu His Asp Ser 
        435                 440                 445             


Gly Val Ser Ala Ala Arg Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
    450                 455                 460                 


Ala Ala Ala Ala Ala Ala Ser Ala Gly Gly Lys Glu Ala Ala Ser Gly 
465                 470                 475                 480 


Pro Asn Asp Ser 
                


<210>  1831
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  1831

Met Ala Leu Thr Gly Ala Ser Asp Pro Ser Ala Glu Ala Glu Ala Asn 
1               5                   10                  15      


Gly Glu Lys Pro Phe Leu Leu Arg Ala Leu Gln Ile Ala Leu Val Val 
            20                  25                  30          


Ser Leu Tyr Trp Val Thr Ser Ile Ser Met Val Phe Leu Asn Lys Tyr 
        35                  40                  45              


Leu Leu Asp Ser Pro Ser Leu Arg Leu Asp Thr Pro Ile Phe Val Thr 
    50                  55                  60                  


Phe Tyr Gln Cys Leu Val Thr Thr Leu Leu Cys Lys Gly Leu Ser Ala 
65                  70                  75                  80  


Leu Ala Ala Cys Cys Pro Gly Ala Val Asp Phe Pro Ser Leu Arg Leu 
                85                  90                  95      


Asp Leu Arg Val Ala Arg Ser Val Leu Pro Leu Ser Val Val Phe Ile 
            100                 105                 110         


Gly Met Ile Thr Phe Asn Asn Leu Cys Leu Lys Tyr Val Gly Val Ala 
        115                 120                 125             


Phe Tyr Asn Val Gly Arg Ser Leu Thr Thr Val Phe Asn Val Leu Leu 
    130                 135                 140                 


Ser Tyr Leu Leu Leu Lys Gln Thr Thr Ser Phe Tyr Ala Leu Leu Thr 
145                 150                 155                 160 


Cys Gly Ile Ile Ile Gly Gly Phe Trp Leu Gly Val Asp Gln Glu Gly 
                165                 170                 175     


Ala Glu Gly Thr Leu Ser Trp Leu Gly Thr Val Phe Gly Val Leu Ala 
            180                 185                 190         


Ser Leu Cys Val Ser Leu Asn Ala Ile Tyr Thr Thr Lys Val Leu Pro 
        195                 200                 205             


Ala Val Asp Gly Ser Ile Trp Arg Leu Thr Phe Tyr Asn Asn Val Asn 
    210                 215                 220                 


Ala Cys Ile Leu Phe Leu Pro Leu Leu Leu Leu Leu Gly Glu Leu Gln 
225                 230                 235                 240 


Ala Leu Arg Asp Phe Ala Gln Leu Gly Ser Ala His Phe Trp Gly Met 
                245                 250                 255     


Met Thr Leu Gly Gly Leu Phe Gly Phe Ala Ile Gly Tyr Val Thr Gly 
            260                 265                 270         


Leu Gln Ile Lys Phe Thr Ser Pro Leu Thr His Asn Val Ser Gly Thr 
        275                 280                 285             


Ala Lys Ala Cys Ala Gln Thr Val Leu Ala Val Leu Tyr Tyr Glu Glu 
    290                 295                 300                 


Thr Lys Ser Phe Leu Trp Trp Thr Ser Asn Met Met Val Leu Gly Gly 
305                 310                 315                 320 


Ser Ser Ala Tyr Thr Trp Val Arg Gly Trp Glu Met Lys Lys Thr Pro 
                325                 330                 335     


Glu Glu Pro Ser Pro Lys Asp Ser Glu Lys Ser Ala Met Gly Val 
            340                 345                 350     


<210>  1832
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  1832

Met Ala Leu Thr Gly Ala Ser Asp Pro Ser Ala Glu Ala Glu Ala Asn 
1               5                   10                  15      


Gly Glu Lys Pro Phe Leu Leu Arg Ala Leu Gln Ile Ala Leu Val Val 
            20                  25                  30          


Ser Leu Tyr Trp Val Thr Ser Ile Ser Met Val Phe Leu Asn Lys Tyr 
        35                  40                  45              


Leu Leu Asp Ser Pro Ser Leu Arg Leu Asp Thr Pro Ile Phe Val Thr 
    50                  55                  60                  


Phe Tyr Gln Cys Leu Val Thr Thr Leu Leu Cys Lys Gly Leu Ser Ala 
65                  70                  75                  80  


Leu Ala Ala Cys Cys Pro Gly Ala Val Asp Phe Pro Ser Leu Arg Leu 
                85                  90                  95      


Asp Leu Arg Val Ala Arg Ser Val Leu Pro Leu Ser Val Val Phe Ile 
            100                 105                 110         


Gly Met Ile Thr Phe Asn Asn Leu Cys Leu Lys Tyr Val Gly Val Ala 
        115                 120                 125             


Phe Tyr Asn Val Gly Arg Ser Leu Thr Thr Val Phe Asn Val Leu Leu 
    130                 135                 140                 


Ser Tyr Leu Leu Leu Lys Gln Thr Thr Ser Phe Tyr Ala Leu Leu Thr 
145                 150                 155                 160 


Cys Gly Ile Ile Ile Gly Gly Phe Trp Leu Gly Val Asp Gln Glu Gly 
                165                 170                 175     


Ala Glu Gly Thr Leu Ser Trp Leu Gly Thr Val Phe Gly Val Leu Ala 
            180                 185                 190         


Ser Leu Cys Val Ser Leu Asn Ala Ile Tyr Thr Thr Lys Val Leu Pro 
        195                 200                 205             


Ala Val Asp Gly Ser Ile Trp Arg Leu Thr Phe Tyr Asn Asn Val Asn 
    210                 215                 220                 


Ala Cys Ile Leu Phe Leu Pro Leu Leu Leu Leu Leu Gly Glu Leu Gln 
225                 230                 235                 240 


Ala Leu Arg Asp Phe Ala Gln Leu Gly Ser Ala His Phe Trp Gly Met 
                245                 250                 255     


Met Thr Leu Gly Gly Leu Phe Gly Phe Ala Ile Gly Tyr Val Thr Gly 
            260                 265                 270         


Leu Gln Ile Lys Phe Thr Ser Pro Leu Thr His Asn Val Ser Gly Thr 
        275                 280                 285             


Ala Lys Ala Cys Ala Gln Thr Val Leu Ala Val Leu Tyr Tyr Glu Glu 
    290                 295                 300                 


Thr Lys Ser Phe Leu Trp Trp Thr Ser Asn Met Met Val Leu Gly Gly 
305                 310                 315                 320 


Ser Ser Ala Tyr Thr Trp Val Arg Gly Trp Glu Met Lys Lys Thr Pro 
                325                 330                 335     


Glu Glu Pro Ser Pro Lys Asp Ser Glu Lys Ser Ala Met Gly Val 
            340                 345                 350     


<210>  1833
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  1833

Met Cys Leu His Arg Arg Val Pro Ser Glu Glu Thr Tyr Ser Leu Asp 
1               5                   10                  15      


Arg Phe Ala Gln Asn Pro Pro Leu Phe Pro Pro Pro Ser Leu Pro Ala 
            20                  25                  30          


Ser Glu Ser Arg Met Ala His Ala Pro Leu Leu Gln Arg Cys Gly Ala 
        35                  40                  45              


Ala Arg Thr Gly Phe Cys Lys Lys Gln Gln Glu Leu Trp Gln Arg Arg 
    50                  55                  60                  


Lys Glu Ala Ala Glu Ala Leu Gly Thr Arg Lys Val Ser Val Leu Leu 
65                  70                  75                  80  


Ala Thr Ser His Ser Gly Ala Arg Pro Ala Val Ser Thr Met Asp Ser 
                85                  90                  95      


Ser Ala Ala Pro Thr Asn Ala Ser Asn Cys Thr Asp Ala Leu Ala Tyr 
            100                 105                 110         


Ser Ser Cys Ser Pro Ala Pro Ser Pro Gly Ser Trp Val Asn Leu Ser 
        115                 120                 125             


His Leu Asp Gly Asn Leu Ser Asp Pro Cys Gly Pro Asn Arg Thr Asp 
    130                 135                 140                 


Leu Gly Gly Arg Asp Ser Leu Cys Pro Pro Thr Gly Ser Pro Ser Met 
145                 150                 155                 160 


Ile Thr Ala Ile Thr Ile Met Ala Leu Tyr Ser Ile Val Cys Val Val 
                165                 170                 175     


Gly Leu Phe Gly Asn Phe Leu Val Met Tyr Val Ile Val Arg Tyr Thr 
            180                 185                 190         


Lys Met Lys Thr Ala Thr Asn Ile Tyr Ile Phe Asn Leu Ala Leu Ala 
        195                 200                 205             


Asp Ala Leu Ala Thr Ser Thr Leu Pro Phe Gln Ser Val Asn Tyr Leu 
    210                 215                 220                 


Met Gly Thr Trp Pro Phe Gly Thr Ile Leu Cys Lys Ile Val Ile Ser 
225                 230                 235                 240 


Ile Asp Tyr Tyr Asn Met Phe Thr Ser Ile Phe Thr Leu Cys Thr Met 
                245                 250                 255     


Ser Val Asp Arg Tyr Ile Ala Val Cys His Pro Val Lys Ala Leu Asp 
            260                 265                 270         


Phe Arg Thr Pro Arg Asn Ala Lys Ile Ile Asn Val Cys Asn Trp Ile 
        275                 280                 285             


Leu Ser Ser Ala Ile Gly Leu Pro Val Met Phe Met Ala Thr Thr Lys 
    290                 295                 300                 


Tyr Arg Gln Gly Ser Ile Asp Cys Thr Leu Thr Phe Ser His Pro Thr 
305                 310                 315                 320 


Trp Tyr Trp Glu Asn Leu Leu Lys Ile Cys Val Phe Ile Phe Ala Phe 
                325                 330                 335     


Ile Met Pro Val Leu Ile Ile Thr Val Cys Tyr Gly Leu Met Ile Leu 
            340                 345                 350         


Arg Leu Lys Ser Val Arg Met Leu Ser Gly Ser Lys Glu Lys Asp Arg 
        355                 360                 365             


Asn Leu Arg Arg Ile Thr Arg Met Val Leu Val Val Val Ala Val Phe 
    370                 375                 380                 


Ile Val Cys Trp Thr Pro Ile His Ile Tyr Val Ile Ile Lys Ala Leu 
385                 390                 395                 400 


Val Thr Ile Pro Glu Thr Thr Phe Gln Thr Val Ser Trp His Phe Cys 
                405                 410                 415     


Ile Ala Leu Gly Tyr Thr Asn Ser Cys Leu Asn Pro Val Leu Tyr Ala 
            420                 425                 430         


Phe Leu Asp Glu Asn Phe Lys Arg Cys Phe Arg Glu Phe Cys Ile Pro 
        435                 440                 445             


Thr Ser Ser Asn Ile Glu Gln Gln Asn Ser Thr Arg Ile Arg Gln Asn 
    450                 455                 460                 


Thr Arg Asp His Pro Ser Thr Ala Asn Thr Val Asp Arg Thr Asn His 
465                 470                 475                 480 


Gln Leu Glu Asn Leu Glu Ala Glu Thr Ala Pro Leu Pro 
                485                 490             


<210>  1834
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  1834

Met Lys Thr Ala Thr Asn Ile Tyr Ile Phe Asn Leu Ala Leu Ala Asp 
1               5                   10                  15      


Ala Leu Ala Thr Ser Thr Leu Pro Phe Gln Ser Val Asn Tyr Leu Met 
            20                  25                  30          


Gly Thr Trp Pro Phe Gly Thr Ile Leu Cys Lys Ile Val Ile Ser Ile 
        35                  40                  45              


Asp Tyr Tyr Asn Met Phe Thr Ser Ile Phe Thr Leu Cys Thr Met Ser 
    50                  55                  60                  


Val Asp Arg Tyr Ile Ala Val Cys His Pro Val Lys Ala Leu Asp Phe 
65                  70                  75                  80  


Arg Thr Pro Arg Asn Ala Lys Ile Ile Asn Val Cys Asn Trp Ile Leu 
                85                  90                  95      


Ser Ser Ala Ile Gly Leu Pro Val Met Phe Met Ala Thr Thr Lys Tyr 
            100                 105                 110         


Arg Gln Gly Ser Ile Asp Cys Thr Leu Thr Phe Ser His Pro Thr Trp 
        115                 120                 125             


Tyr Trp Glu Asn Leu Leu Lys Ile Cys Val Phe Ile Phe Ala Phe Ile 
    130                 135                 140                 


Met Pro Val Leu Ile Ile Thr Val Cys Tyr Gly Leu Met Ile Leu Arg 
145                 150                 155                 160 


Leu Lys Ser Val Arg Met Leu Ser Gly Ser Lys Glu Lys Asp Arg Asn 
                165                 170                 175     


Leu Arg Arg Ile Thr Arg Met Val Leu Val Val Val Ala Val Phe Ile 
            180                 185                 190         


Val Cys Trp Thr Pro Ile His Ile Tyr Val Ile Ile Lys Ala Leu Val 
        195                 200                 205             


Thr Ile Pro Glu Thr Thr Phe Gln Thr Val Ser Trp His Phe Cys Ile 
    210                 215                 220                 


Ala Leu Gly Tyr Thr Asn Ser Cys Leu Asn Pro Val Leu Tyr Ala Phe 
225                 230                 235                 240 


Leu Asp Glu Asn Phe Lys Arg Cys Phe Arg Glu Phe Cys Ile Pro Thr 
                245                 250                 255     


Ser Ser Asn Ile Glu Gln Gln Asn Ser Thr Arg Ile Arg Gln Asn Thr 
            260                 265                 270         


Arg Asp His Pro Ser Thr Ala Asn Thr Val Asp Arg Thr Asn His Gln 
        275                 280                 285             


Leu Glu Asn Leu Glu Ala Glu Thr Ala Pro Leu Pro 
    290                 295                 300 


<210>  1835
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  1835

Met Met Arg Ala Lys Ser Ile Ser Thr Lys Ala Gly Lys Pro Ser Arg 
1               5                   10                  15      


Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile Tyr Ile Phe Asn Leu Ala 
            20                  25                  30          


Leu Ala Asp Ala Leu Ala Thr Ser Thr Leu Pro Phe Gln Ser Val Asn 
        35                  40                  45              


Tyr Leu Met Gly Thr Trp Pro Phe Gly Thr Ile Leu Cys Lys Ile Val 
    50                  55                  60                  


Ile Ser Ile Asp Tyr Tyr Asn Met Phe Thr Ser Ile Phe Thr Leu Cys 
65                  70                  75                  80  


Thr Met Ser Val Asp Arg Tyr Ile Ala Val Cys His Pro Val Lys Ala 
                85                  90                  95      


Leu Asp Phe Arg Thr Pro Arg Asn Ala Lys Ile Ile Asn Val Cys Asn 
            100                 105                 110         


Trp Ile Leu Ser Ser Ala Ile Gly Leu Pro Val Met Phe Met Ala Thr 
        115                 120                 125             


Thr Lys Tyr Arg Gln Gly Ser Ile Asp Cys Thr Leu Thr Phe Ser His 
    130                 135                 140                 


Pro Thr Trp Tyr Trp Glu Asn Leu Leu Lys Ile Cys Val Phe Ile Phe 
145                 150                 155                 160 


Ala Phe Ile Met Pro Val Leu Ile Ile Thr Val Cys Tyr Gly Leu Met 
                165                 170                 175     


Ile Leu Arg Leu Lys Ser Val Arg Met Leu Ser Gly Ser Lys Glu Lys 
            180                 185                 190         


Asp Arg Asn Leu Arg Arg Ile Thr Arg Met Val Leu Val Val Val Ala 
        195                 200                 205             


Val Phe Ile Val Cys Trp Thr Pro Ile His Ile Tyr Val Ile Ile Lys 
    210                 215                 220                 


Ala Leu Val Thr Ile Pro Glu Thr Thr Phe Gln Thr Val Ser Trp His 
225                 230                 235                 240 


Phe Cys Ile Ala Leu Gly Tyr Thr Asn Ser Cys Leu Asn Pro Val Leu 
                245                 250                 255     


Tyr Ala Phe Leu Asp Glu Asn Phe Lys Arg Cys Phe Arg Glu Phe Cys 
            260                 265                 270         


Ile Pro Thr Ser Ser Asn Ile Glu Gln Gln Asn Ser Thr Arg Ile Arg 
        275                 280                 285             


Gln Asn Thr Arg Asp His Pro Ser Thr Ala Asn Thr Val Asp Arg Thr 
    290                 295                 300                 


Asn His Gln Leu Glu Asn Leu Glu Ala Glu Thr Ala Pro Leu Pro 
305                 310                 315                 


<210>  1836
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  1836

Met Asp Ser Ser Ala Ala Pro Thr Asn Ala Ser Asn Cys Thr Asp Ala 
1               5                   10                  15      


Leu Ala Tyr Ser Ser Cys Ser Pro Ala Pro Ser Pro Gly Ser Trp Val 
            20                  25                  30          


Asn Leu Ser His Leu Asp Gly Asn Leu Ser Asp Pro Cys Gly Pro Asn 
        35                  40                  45              


Arg Thr Asp Leu Gly Gly Arg Asp Ser Leu Cys Pro Pro Thr Gly Ser 
    50                  55                  60                  


Pro Ser Met Ile Thr Ala Ile Thr Ile Met Ala Leu Tyr Ser Ile Val 
65                  70                  75                  80  


Cys Val Val Gly Leu Phe Gly Asn Phe Leu Val Met Tyr Val Ile Val 
                85                  90                  95      


Arg Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile Tyr Ile Phe Asn Leu 
            100                 105                 110         


Ala Leu Ala Asp Ala Leu Ala Thr Ser Thr Leu Pro Phe Gln Ser Val 
        115                 120                 125             


Asn Tyr Leu Met Gly Thr Trp Pro Phe Gly Thr Ile Leu Cys Lys Ile 
    130                 135                 140                 


Val Ile Ser Ile Asp Tyr Tyr Asn Met Phe Thr Ser Ile Phe Thr Leu 
145                 150                 155                 160 


Cys Thr Met Ser Val Asp Arg Tyr Ile Ala Val Cys His Pro Val Lys 
                165                 170                 175     


Ala Leu Asp Phe Arg Thr Pro Arg Asn Ala Lys Ile Ile Asn Val Cys 
            180                 185                 190         


Asn Trp Ile Leu Ser Ser Ala Ile Gly Leu Pro Val Met Phe Met Ala 
        195                 200                 205             


Thr Thr Lys Tyr Arg Gln Gly Ser Ile Asp Cys Thr Leu Thr Phe Ser 
    210                 215                 220                 


His Pro Thr Trp Tyr Trp Glu Asn Leu Leu Lys Ile Cys Val Phe Ile 
225                 230                 235                 240 


Phe Ala Phe Ile Met Pro Val Leu Ile Ile Thr Val Cys Tyr Gly Leu 
                245                 250                 255     


Met Ile Leu Arg Leu Lys Ser Val Arg Met Leu Ser Gly Ser Lys Glu 
            260                 265                 270         


Lys Asp Arg Asn Leu Arg Arg Ile Thr Arg Met Val Leu Val Val Val 
        275                 280                 285             


Ala Val Phe Ile Val Cys Trp Thr Pro Ile His Ile Tyr Val Ile Ile 
    290                 295                 300                 


Lys Ala Leu Val Thr Ile Pro Glu Thr Thr Phe Gln Thr Val Ser Trp 
305                 310                 315                 320 


His Phe Cys Ile Ala Leu Gly Tyr Thr Asn Ser Cys Leu Asn Pro Val 
                325                 330                 335     


Leu Tyr Ala Phe Leu Asp Glu Asn Phe Lys Arg Cys Phe Arg Glu Phe 
            340                 345                 350         


Cys Ile Pro Thr Ser Ser Asn Ile Glu Gln Gln Asn Ser Thr Arg Ile 
        355                 360                 365             


Arg Gln Asn Thr Arg Asp His Pro Ser Thr Ala Asn Thr Val Asp Arg 
    370                 375                 380                 


Thr Asn His Gln Lys Ile Asp Leu Phe Gln Lys Ser Ser Leu Leu Asn 
385                 390                 395                 400 


Cys Glu His Thr Lys Gly 
                405     


<210>  1837
<211>  397
<212>  PRT
<213>  Homo sapiens

<400>  1837

Met Asp Ser Ser Ala Ala Pro Thr Asn Ala Ser Asn Cys Thr Asp Ala 
1               5                   10                  15      


Leu Ala Tyr Ser Ser Cys Ser Pro Ala Pro Ser Pro Gly Ser Trp Val 
            20                  25                  30          


Asn Leu Ser His Leu Asp Gly Asn Leu Ser Asp Pro Cys Gly Pro Asn 
        35                  40                  45              


Arg Thr Asp Leu Gly Gly Arg Asp Ser Leu Cys Pro Pro Thr Gly Ser 
    50                  55                  60                  


Pro Ser Met Ile Thr Ala Ile Thr Ile Met Ala Leu Tyr Ser Ile Val 
65                  70                  75                  80  


Cys Val Val Gly Leu Phe Gly Asn Phe Leu Val Met Tyr Val Ile Val 
                85                  90                  95      


Arg Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile Tyr Ile Phe Asn Leu 
            100                 105                 110         


Ala Leu Ala Asp Ala Leu Ala Thr Ser Thr Leu Pro Phe Gln Ser Val 
        115                 120                 125             


Asn Tyr Leu Met Gly Thr Trp Pro Phe Gly Thr Ile Leu Cys Lys Ile 
    130                 135                 140                 


Val Ile Ser Ile Asp Tyr Tyr Asn Met Phe Thr Ser Ile Phe Thr Leu 
145                 150                 155                 160 


Cys Thr Met Ser Val Asp Arg Tyr Ile Ala Val Cys His Pro Val Lys 
                165                 170                 175     


Ala Leu Asp Phe Arg Thr Pro Arg Asn Ala Lys Ile Ile Asn Val Cys 
            180                 185                 190         


Asn Trp Ile Leu Ser Ser Ala Ile Gly Leu Pro Val Met Phe Met Ala 
        195                 200                 205             


Thr Thr Lys Tyr Arg Gln Gly Ser Ile Asp Cys Thr Leu Thr Phe Ser 
    210                 215                 220                 


His Pro Thr Trp Tyr Trp Glu Asn Leu Leu Lys Ile Cys Val Phe Ile 
225                 230                 235                 240 


Phe Ala Phe Ile Met Pro Val Leu Ile Ile Thr Val Cys Tyr Gly Leu 
                245                 250                 255     


Met Ile Leu Arg Leu Lys Ser Val Arg Met Leu Ser Gly Ser Lys Glu 
            260                 265                 270         


Lys Asp Arg Asn Leu Arg Arg Ile Thr Arg Met Val Leu Val Val Val 
        275                 280                 285             


Ala Val Phe Ile Val Cys Trp Thr Pro Ile His Ile Tyr Val Ile Ile 
    290                 295                 300                 


Lys Ala Leu Val Thr Ile Pro Glu Thr Thr Phe Gln Thr Val Ser Trp 
305                 310                 315                 320 


His Phe Cys Ile Ala Leu Gly Tyr Thr Asn Ser Cys Leu Asn Pro Val 
                325                 330                 335     


Leu Tyr Ala Phe Leu Asp Glu Asn Phe Lys Arg Cys Phe Arg Glu Phe 
            340                 345                 350         


Cys Ile Pro Thr Ser Ser Asn Ile Glu Gln Gln Asn Ser Thr Arg Ile 
        355                 360                 365             


Arg Gln Asn Thr Arg Asp His Pro Ser Thr Ala Asn Thr Val Asp Arg 
    370                 375                 380                 


Thr Asn His Gln Arg Glu Arg Arg Gln Lys Ser Asp Trp 
385                 390                 395         


<210>  1838
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  1838

Met Asp Ser Ser Ala Ala Pro Thr Asn Ala Ser Asn Cys Thr Asp Ala 
1               5                   10                  15      


Leu Ala Tyr Ser Ser Cys Ser Pro Ala Pro Ser Pro Gly Ser Trp Val 
            20                  25                  30          


Asn Leu Ser His Leu Asp Gly Asn Leu Ser Asp Pro Cys Gly Pro Asn 
        35                  40                  45              


Arg Thr Asp Leu Gly Gly Arg Asp Ser Leu Cys Pro Pro Thr Gly Ser 
    50                  55                  60                  


Pro Ser Met Ile Thr Ala Ile Thr Ile Met Ala Leu Tyr Ser Ile Val 
65                  70                  75                  80  


Cys Val Val Gly Leu Phe Gly Asn Phe Leu Val Met Tyr Val Ile Val 
                85                  90                  95      


Arg Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile Tyr Ile Phe Asn Leu 
            100                 105                 110         


Ala Leu Ala Asp Ala Leu Ala Thr Ser Thr Leu Pro Phe Gln Ser Val 
        115                 120                 125             


Asn Tyr Leu Met Gly Thr Trp Pro Phe Gly Thr Ile Leu Cys Lys Ile 
    130                 135                 140                 


Val Ile Ser Ile Asp Tyr Tyr Asn Met Phe Thr Ser Ile Phe Thr Leu 
145                 150                 155                 160 


Cys Thr Met Ser Val Asp Arg Tyr Ile Ala Val Cys His Pro Val Lys 
                165                 170                 175     


Ala Leu Asp Phe Arg Thr Pro Arg Asn Ala Lys Ile Ile Asn Val Cys 
            180                 185                 190         


Asn Trp Ile Leu Ser Ser Ala Ile Gly Leu Pro Val Met Phe Met Ala 
        195                 200                 205             


Thr Thr Lys Tyr Arg Gln Gly Ser Ile Asp Cys Thr Leu Thr Phe Ser 
    210                 215                 220                 


His Pro Thr Trp Tyr Trp Glu Asn Leu Leu Lys Ile Cys Val Phe Ile 
225                 230                 235                 240 


Phe Ala Phe Ile Met Pro Val Leu Ile Ile Thr Val Cys Tyr Gly Leu 
                245                 250                 255     


Met Ile Leu Arg Leu Lys Ser Val Arg Met Leu Ser Gly Ser Lys Glu 
            260                 265                 270         


Lys Asp Arg Asn Leu Arg Arg Ile Thr Arg Met Val Leu Val Val Val 
        275                 280                 285             


Ala Val Phe Ile Val Cys Trp Thr Pro Ile His Ile Tyr Val Ile Ile 
    290                 295                 300                 


Lys Ala Leu Val Thr Ile Pro Glu Thr Thr Phe Gln Thr Val Ser Trp 
305                 310                 315                 320 


His Phe Cys Ile Ala Leu Gly Tyr Thr Asn Ser Cys Leu Asn Pro Val 
                325                 330                 335     


Leu Tyr Ala Phe Leu Asp Glu Asn Phe Lys Arg Cys Phe Arg Glu Phe 
            340                 345                 350         


Cys Ile Pro Thr Ser Ser Asn Ile Glu Gln Gln Asn Ser Thr Arg Ile 
        355                 360                 365             


Arg Gln Asn Thr Arg Asp His Pro Ser Thr Ala Asn Thr Val Asp Arg 
    370                 375                 380                 


Thr Asn His Gln Gly Pro Pro Ala Lys Phe Val Ala Asp Gln Leu Ala 
385                 390                 395                 400 


Gly Ser Ser 
            


<210>  1839
<211>  389
<212>  PRT
<213>  Homo sapiens

<400>  1839

Met Asp Ser Ser Ala Ala Pro Thr Asn Ala Ser Asn Cys Thr Asp Ala 
1               5                   10                  15      


Leu Ala Tyr Ser Ser Cys Ser Pro Ala Pro Ser Pro Gly Ser Trp Val 
            20                  25                  30          


Asn Leu Ser His Leu Asp Gly Asn Leu Ser Asp Pro Cys Gly Pro Asn 
        35                  40                  45              


Arg Thr Asp Leu Gly Gly Arg Asp Ser Leu Cys Pro Pro Thr Gly Ser 
    50                  55                  60                  


Pro Ser Met Ile Thr Ala Ile Thr Ile Met Ala Leu Tyr Ser Ile Val 
65                  70                  75                  80  


Cys Val Val Gly Leu Phe Gly Asn Phe Leu Val Met Tyr Val Ile Val 
                85                  90                  95      


Arg Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile Tyr Ile Phe Asn Leu 
            100                 105                 110         


Ala Leu Ala Asp Ala Leu Ala Thr Ser Thr Leu Pro Phe Gln Ser Val 
        115                 120                 125             


Asn Tyr Leu Met Gly Thr Trp Pro Phe Gly Thr Ile Leu Cys Lys Ile 
    130                 135                 140                 


Val Ile Ser Ile Asp Tyr Tyr Asn Met Phe Thr Ser Ile Phe Thr Leu 
145                 150                 155                 160 


Cys Thr Met Ser Val Asp Arg Tyr Ile Ala Val Cys His Pro Val Lys 
                165                 170                 175     


Ala Leu Asp Phe Arg Thr Pro Arg Asn Ala Lys Ile Ile Asn Val Cys 
            180                 185                 190         


Asn Trp Ile Leu Ser Ser Ala Ile Gly Leu Pro Val Met Phe Met Ala 
        195                 200                 205             


Thr Thr Lys Tyr Arg Gln Gly Ser Ile Asp Cys Thr Leu Thr Phe Ser 
    210                 215                 220                 


His Pro Thr Trp Tyr Trp Glu Asn Leu Leu Lys Ile Cys Val Phe Ile 
225                 230                 235                 240 


Phe Ala Phe Ile Met Pro Val Leu Ile Ile Thr Val Cys Tyr Gly Leu 
                245                 250                 255     


Met Ile Leu Arg Leu Lys Ser Val Arg Met Leu Ser Gly Ser Lys Glu 
            260                 265                 270         


Lys Asp Arg Asn Leu Arg Arg Ile Thr Arg Met Val Leu Val Val Val 
        275                 280                 285             


Ala Val Phe Ile Val Cys Trp Thr Pro Ile His Ile Tyr Val Ile Ile 
    290                 295                 300                 


Lys Ala Leu Val Thr Ile Pro Glu Thr Thr Phe Gln Thr Val Ser Trp 
305                 310                 315                 320 


His Phe Cys Ile Ala Leu Gly Tyr Thr Asn Ser Cys Leu Asn Pro Val 
                325                 330                 335     


Leu Tyr Ala Phe Leu Asp Glu Asn Phe Lys Arg Cys Phe Arg Glu Phe 
            340                 345                 350         


Cys Ile Pro Thr Ser Ser Asn Ile Glu Gln Gln Asn Ser Thr Arg Ile 
        355                 360                 365             


Arg Gln Asn Thr Arg Asp His Pro Ser Thr Ala Asn Thr Val Asp Arg 
    370                 375                 380                 


Thr Asn His Gln Ser 
385                 


<210>  1840
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  1840

Met Asp Ser Ser Ala Ala Pro Thr Asn Ala Ser Asn Cys Thr Asp Ala 
1               5                   10                  15      


Leu Ala Tyr Ser Ser Cys Ser Pro Ala Pro Ser Pro Gly Ser Trp Val 
            20                  25                  30          


Asn Leu Ser His Leu Asp Gly Asn Leu Ser Asp Pro Cys Gly Pro Asn 
        35                  40                  45              


Arg Thr Asp Leu Gly Gly Arg Asp Ser Leu Cys Pro Pro Thr Gly Ser 
    50                  55                  60                  


Pro Ser Met Ile Thr Ala Ile Thr Ile Met Ala Leu Tyr Ser Ile Val 
65                  70                  75                  80  


Cys Val Val Gly Leu Phe Gly Asn Phe Leu Val Met Tyr Val Ile Val 
                85                  90                  95      


Arg Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile Tyr Ile Phe Asn Leu 
            100                 105                 110         


Ala Leu Ala Asp Ala Leu Ala Thr Ser Thr Leu Pro Phe Gln Ser Val 
        115                 120                 125             


Asn Tyr Leu Met Gly Thr Trp Pro Phe Gly Thr Ile Leu Cys Lys Ile 
    130                 135                 140                 


Val Ile Ser Ile Asp Tyr Tyr Asn Met Phe Thr Ser Ile Phe Thr Leu 
145                 150                 155                 160 


Cys Thr Met Ser Val Asp Arg Tyr Ile Ala Val Cys His Pro Val Lys 
                165                 170                 175     


Ala Leu Asp Phe Arg Thr Pro Arg Asn Ala Lys Ile Ile Asn Val Cys 
            180                 185                 190         


Asn Trp Ile Leu Ser Ser Ala Ile Gly Leu Pro Val Met Phe Met Ala 
        195                 200                 205             


Thr Thr Lys Tyr Arg Gln Gly Ser Ile Asp Cys Thr Leu Thr Phe Ser 
    210                 215                 220                 


His Pro Thr Trp Tyr Trp Glu Asn Leu Leu Lys Ile Cys Val Phe Ile 
225                 230                 235                 240 


Phe Ala Phe Ile Met Pro Val Leu Ile Ile Thr Val Cys Tyr Gly Leu 
                245                 250                 255     


Met Ile Leu Arg Leu Lys Ser Val Arg Met Leu Ser Gly Ser Lys Glu 
            260                 265                 270         


Lys Asp Arg Asn Leu Arg Arg Ile Thr Arg Met Val Leu Val Val Val 
        275                 280                 285             


Ala Val Phe Ile Val Cys Trp Thr Pro Ile His Ile Tyr Val Ile Ile 
    290                 295                 300                 


Lys Ala Leu Val Thr Ile Pro Glu Thr Thr Phe Gln Thr Val Ser Trp 
305                 310                 315                 320 


His Phe Cys Ile Ala Leu Gly Tyr Thr Asn Ser Cys Leu Asn Pro Val 
                325                 330                 335     


Leu Tyr Ala Phe Leu Asp Glu Asn Phe Lys Arg Cys Phe Arg Glu Phe 
            340                 345                 350         


Cys Ile Pro Thr Ser Ser Asn Ile Glu Gln Gln Asn Ser Thr Arg Ile 
        355                 360                 365             


Arg Gln Asn Thr Arg Asp His Pro Ser Thr Ala Asn Thr Val Asp Arg 
    370                 375                 380                 


Thr Asn His Gln Val Glu Leu Asn Leu Asp Cys His Cys Glu Asn Ala 
385                 390                 395                 400 


Lys Pro Trp Pro Leu Ser Tyr Asn Ala Gly Gln Ser Pro Phe Pro Phe 
                405                 410                 415     


Pro Gly Arg Val 
            420 


<210>  1841
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  1841

Met Lys Thr Ala Thr Asn Ile Tyr Ile Phe Asn Leu Ala Leu Ala Asp 
1               5                   10                  15      


Ala Leu Ala Thr Ser Thr Leu Pro Phe Gln Ser Val Asn Tyr Leu Met 
            20                  25                  30          


Gly Thr Trp Pro Phe Gly Thr Ile Leu Cys Lys Ile Val Ile Ser Ile 
        35                  40                  45              


Asp Tyr Tyr Asn Met Phe Thr Ser Ile Phe Thr Leu Cys Thr Met Ser 
    50                  55                  60                  


Val Asp Arg Tyr Ile Ala Val Cys His Pro Val Lys Ala Leu Asp Phe 
65                  70                  75                  80  


Arg Thr Pro Arg Asn Ala Lys Ile Ile Asn Val Cys Asn Trp Ile Leu 
                85                  90                  95      


Ser Ser Ala Ile Gly Leu Pro Val Met Phe Met Ala Thr Thr Lys Tyr 
            100                 105                 110         


Arg Gln Gly Ser Ile Asp Cys Thr Leu Thr Phe Ser His Pro Thr Trp 
        115                 120                 125             


Tyr Trp Glu Asn Leu Leu Lys Ile Cys Val Phe Ile Phe Ala Phe Ile 
    130                 135                 140                 


Met Pro Val Leu Ile Ile Thr Val Cys Tyr Gly Leu Met Ile Leu Arg 
145                 150                 155                 160 


Leu Lys Ser Val Arg Met Leu Ser Gly Ser Lys Glu Lys Asp Arg Asn 
                165                 170                 175     


Leu Arg Arg Ile Thr Arg Met Val Leu Val Val Val Ala Val Phe Ile 
            180                 185                 190         


Val Cys Trp Thr Pro Ile His Ile Tyr Val Ile Ile Lys Ala Leu Val 
        195                 200                 205             


Thr Ile Pro Glu Thr Thr Phe Gln Thr Val Ser Trp His Phe Cys Ile 
    210                 215                 220                 


Ala Leu Gly Tyr Thr Asn Ser Cys Leu Asn Pro Val Leu Tyr Ala Phe 
225                 230                 235                 240 


Leu Asp Glu Asn Phe Lys Arg Cys Phe Arg Glu Phe Cys Ile Pro Thr 
                245                 250                 255     


Ser Ser Asn Ile Glu Gln Gln Asn Ser Thr Arg Ile Arg Gln Asn Thr 
            260                 265                 270         


Arg Asp His Pro Ser Thr Ala Asn Thr Val Asp Arg Thr Asn His Gln 
        275                 280                 285             


Leu Glu Asn Leu Glu Ala Glu Thr Ala Pro Leu Pro 
    290                 295                 300 


<210>  1842
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  1842

Met Pro Phe Lys Ala Phe Asp Thr Phe Lys Glu Lys Ile Leu Lys Pro 
1               5                   10                  15      


Gly Lys Glu Gly Val Lys Asn Ala Val Gly Asp Ser Leu Gly Ile Leu 
            20                  25                  30          


Gln Arg Lys Ile Asp Gly Thr Thr Glu Glu Glu Asp Asn Ile Glu Leu 
        35                  40                  45              


Asn Glu Glu Gly Arg Pro Val Gln Thr Ser Arg Pro Ser Pro Pro Leu 
    50                  55                  60                  


Cys Asp Cys His Cys Cys Gly Leu Pro Lys Arg Tyr Ile Ile Ala Ile 
65                  70                  75                  80  


Met Ser Gly Leu Gly Phe Cys Ile Ser Phe Gly Ile Arg Cys Asn Leu 
                85                  90                  95      


Gly Val Ala Ile Val Glu Met Val Asn Asn Ser Thr Val Tyr Val Asp 
            100                 105                 110         


Gly Lys Pro Glu Ile Gln Thr Ala Gln Phe Asn Trp Asp Pro Glu Thr 
        115                 120                 125             


Val Gly Leu Ile His Gly Ser Phe Phe Trp Gly Tyr Ile Met Thr Gln 
    130                 135                 140                 


Ile Pro Gly Gly Phe Ile Ser Asn Lys Phe Ala Ala Asn Arg Val Phe 
145                 150                 155                 160 


Gly Ala Ala Ile Phe Leu Thr Ser Thr Leu Asn Met Phe Ile Pro Ser 
                165                 170                 175     


Ala Ala Arg Val His Tyr Gly Cys Val Met Cys Val Arg Ile Leu Gln 
            180                 185                 190         


Gly Leu Val Glu Gly Val Thr Tyr Pro Ala Cys His Gly Met Trp Ser 
        195                 200                 205             


Lys Trp Ala Pro Pro Leu Glu Arg Ser Arg Leu Ala Thr Thr Ser Phe 
    210                 215                 220                 


Cys Gly Ser Tyr Ala Gly Ala Val Val Ala Met Pro Leu Ala Gly Val 
225                 230                 235                 240 


Leu Val Gln Tyr Ile Gly Trp Ser Ser Val Phe Tyr Ile Tyr Gly Met 
                245                 250                 255     


Phe Gly Ile Ile Trp Tyr Met Phe Trp Leu Leu Gln Ala Tyr Glu Cys 
            260                 265                 270         


Pro Ala Ala His Pro Thr Ile Ser Asn Glu Glu Lys Thr Tyr Ile Glu 
        275                 280                 285             


Thr Ser Ile Gly Glu Gly Ala Asn Val Val Ser Leu Ser Val Gly Leu 
    290                 295                 300                 


Leu Ser Ala Val Pro His Met Val Met Thr Ile Val Val Pro Ile Gly 
305                 310                 315                 320 


Gly Gln Leu Ala Asp Tyr Leu Arg Ser Arg Gln Ile Leu Thr Thr Thr 
                325                 330                 335     


Ala Val Arg Lys Ile Met Asn Cys Gly Gly Phe Gly Met Glu Ala Thr 
            340                 345                 350         


Leu Leu Leu Val Val Gly Phe Ser His Thr Lys Gly Val Ala Ile Ser 
        355                 360                 365             


Phe Leu Val Leu Ala Val Gly Phe Ser Gly Phe Ala Ile Ser Gly Phe 
    370                 375                 380                 


Asn Val Asn His Leu Asp Ile Ala Pro Arg Tyr Ala Ser Ile Leu Met 
385                 390                 395                 400 


Gly Ile Ser Asn Gly Val Gly Thr Leu Ser Gly Met Val Cys Pro Leu 
                405                 410                 415     


Ile Val Gly Ala Met Thr Arg His Lys Thr Arg Glu Glu Trp Gln Asn 
            420                 425                 430         


Val Phe Leu Ile Ala Ala Leu Val His Tyr Ser Gly Val Ile Phe Tyr 
        435                 440                 445             


Gly Val Phe Ala Ser Gly Glu Lys Gln Glu Trp Ala Asp Pro Glu Asn 
    450                 455                 460                 


Leu Ser Glu Glu Lys Cys Gly Ile Ile Asp Gln Asp Glu Leu Ala Glu 
465                 470                 475                 480 


Glu Ile Glu Leu Asn His Glu Ser Phe Ala Ser Pro Lys Lys Lys Met 
                485                 490                 495     


Ser Tyr Gly Ala Thr Ser Gln Asn Cys Glu Val Gln Lys Lys Glu Trp 
            500                 505                 510         


Lys Gly Gln Arg Gly Ala Thr Leu Asp Glu Glu Glu Leu Thr Ser Tyr 
        515                 520                 525             


Gln Asn Glu Glu Arg Asn Phe Ser Thr Ile Ser 
    530                 535                 


<210>  1843
<211>  853
<212>  PRT
<213>  Homo sapiens

<400>  1843

Met Ser Leu Ser Glu Glu Gln Ala Arg Ser Phe Leu Asp Gln Asn Pro 
1               5                   10                  15      


Asp Phe Ala Arg Gln Tyr Phe Gly Lys Lys Leu Ser Pro Glu Asn Val 
            20                  25                  30          


Ala Ala Ala Cys Glu Asp Gly Cys Pro Pro Asp Cys Asp Ser Leu Arg 
        35                  40                  45              


Asp Leu Cys Gln Val Glu Glu Ser Thr Ala Leu Leu Glu Leu Val Gln 
    50                  55                  60                  


Asp Met Gln Glu Ser Ile Asn Met Glu Arg Val Val Phe Lys Val Leu 
65                  70                  75                  80  


Arg Arg Leu Cys Thr Leu Leu Gln Ala Asp Arg Cys Ser Leu Phe Met 
                85                  90                  95      


Tyr Arg Gln Arg Asn Gly Val Ala Glu Leu Ala Thr Arg Leu Phe Ser 
            100                 105                 110         


Val Gln Pro Asp Ser Val Leu Glu Asp Cys Leu Val Pro Pro Asp Ser 
        115                 120                 125             


Glu Ile Val Phe Pro Leu Asp Ile Gly Val Val Gly His Val Ala Gln 
    130                 135                 140                 


Thr Lys Lys Met Val Asn Val Glu Asp Val Ala Glu Cys Pro His Phe 
145                 150                 155                 160 


Ser Ser Phe Ala Asp Glu Leu Thr Asp Tyr Lys Thr Lys Asn Met Leu 
                165                 170                 175     


Ala Thr Pro Ile Met Asn Gly Lys Asp Val Val Ala Val Ile Met Ala 
            180                 185                 190         


Val Asn Lys Leu Asn Gly Pro Phe Phe Thr Ser Glu Asp Glu Asp Val 
        195                 200                 205             


Phe Leu Lys Tyr Leu Asn Phe Ala Thr Leu Tyr Leu Lys Ile Tyr His 
    210                 215                 220                 


Leu Ser Tyr Leu His Asn Cys Glu Thr Arg Arg Gly Gln Val Leu Leu 
225                 230                 235                 240 


Trp Ser Ala Asn Lys Val Phe Glu Glu Leu Thr Asp Ile Glu Arg Gln 
                245                 250                 255     


Phe His Lys Ala Phe Tyr Thr Val Arg Ala Tyr Leu Asn Cys Glu Arg 
            260                 265                 270         


Tyr Ser Val Gly Leu Leu Asp Met Thr Lys Glu Lys Glu Phe Phe Asp 
        275                 280                 285             


Val Trp Ser Val Leu Met Gly Glu Ser Gln Pro Tyr Ser Gly Pro Arg 
    290                 295                 300                 


Thr Pro Asp Gly Arg Glu Ile Val Phe Tyr Lys Val Ile Asp Tyr Ile 
305                 310                 315                 320 


Leu His Gly Lys Glu Glu Ile Lys Val Ile Pro Thr Pro Ser Ala Asp 
                325                 330                 335     


His Trp Ala Leu Ala Ser Gly Leu Pro Ser Tyr Val Ala Glu Ser Gly 
            340                 345                 350         


Phe Ile Cys Asn Ile Met Asn Ala Ser Ala Asp Glu Met Phe Lys Phe 
        355                 360                 365             


Gln Glu Gly Ala Leu Asp Asp Ser Gly Trp Leu Ile Lys Asn Val Leu 
    370                 375                 380                 


Ser Met Pro Ile Val Asn Lys Lys Glu Glu Ile Val Gly Val Ala Thr 
385                 390                 395                 400 


Phe Tyr Asn Arg Lys Asp Gly Lys Pro Phe Asp Glu Gln Asp Glu Val 
                405                 410                 415     


Leu Met Glu Ser Leu Thr Gln Phe Leu Gly Trp Ser Val Met Asn Thr 
            420                 425                 430         


Asp Thr Tyr Asp Lys Met Asn Lys Leu Glu Asn Arg Lys Asp Ile Ala 
        435                 440                 445             


Gln Asp Met Val Leu Tyr His Val Lys Cys Asp Arg Asp Glu Ile Gln 
    450                 455                 460                 


Leu Ile Leu Pro Thr Arg Ala Arg Leu Gly Lys Glu Pro Ala Asp Cys 
465                 470                 475                 480 


Asp Glu Asp Glu Leu Gly Glu Ile Leu Lys Glu Glu Leu Pro Gly Pro 
                485                 490                 495     


Thr Thr Phe Asp Ile Tyr Glu Phe His Phe Ser Asp Leu Glu Cys Thr 
            500                 505                 510         


Glu Leu Asp Leu Val Lys Cys Gly Ile Gln Met Tyr Tyr Glu Leu Gly 
        515                 520                 525             


Val Val Arg Lys Phe Gln Ile Pro Gln Glu Val Leu Val Arg Phe Leu 
    530                 535                 540                 


Phe Ser Ile Ser Lys Gly Tyr Arg Arg Ile Thr Tyr His Asn Trp Arg 
545                 550                 555                 560 


His Gly Phe Asn Val Ala Gln Thr Met Phe Thr Leu Leu Met Thr Gly 
                565                 570                 575     


Lys Leu Lys Ser Tyr Tyr Thr Asp Leu Glu Ala Phe Ala Met Val Thr 
            580                 585                 590         


Ala Gly Leu Cys His Asp Ile Asp His Arg Gly Thr Asn Asn Leu Tyr 
        595                 600                 605             


Gln Met Lys Ser Gln Asn Pro Leu Ala Lys Leu His Gly Ser Ser Ile 
    610                 615                 620                 


Leu Glu Arg His His Leu Glu Phe Gly Lys Phe Leu Leu Ser Glu Glu 
625                 630                 635                 640 


Thr Leu Asn Ile Tyr Gln Asn Leu Asn Arg Arg Gln His Glu His Val 
                645                 650                 655     


Ile His Leu Met Asp Ile Ala Ile Ile Ala Thr Asp Leu Ala Leu Tyr 
            660                 665                 670         


Phe Lys Lys Arg Ala Met Phe Gln Lys Ile Val Asp Glu Ser Lys Asn 
        675                 680                 685             


Tyr Gln Asp Lys Lys Ser Trp Val Glu Tyr Leu Ser Leu Glu Thr Thr 
    690                 695                 700                 


Arg Lys Glu Ile Val Met Ala Met Met Met Thr Ala Cys Asp Leu Ser 
705                 710                 715                 720 


Ala Ile Thr Lys Pro Trp Glu Val Gln Ser Lys Val Ala Leu Leu Val 
                725                 730                 735     


Ala Ala Glu Phe Trp Glu Gln Gly Asp Leu Glu Arg Thr Val Leu Asp 
            740                 745                 750         


Gln Gln Pro Ile Pro Met Met Asp Arg Asn Lys Ala Ala Glu Leu Pro 
        755                 760                 765             


Lys Leu Gln Val Gly Phe Ile Asp Phe Val Cys Thr Phe Val Tyr Lys 
    770                 775                 780                 


Glu Phe Ser Arg Phe His Glu Glu Ile Leu Pro Met Phe Asp Arg Leu 
785                 790                 795                 800 


Gln Asn Asn Arg Lys Glu Trp Lys Ala Leu Ala Asp Glu Tyr Glu Ala 
                805                 810                 815     


Lys Val Lys Ala Leu Glu Glu Lys Glu Glu Glu Glu Arg Val Ala Ala 
            820                 825                 830         


Lys Lys Gly Thr Glu Ile Cys Asn Gly Gly Pro Ala Pro Lys Ser Ser 
        835                 840                 845             


Thr Cys Cys Ile Leu 
    850             


<210>  1844
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  1844

Met Thr Lys Glu Lys Glu Phe Phe Asp Val Trp Ser Val Leu Met Gly 
1               5                   10                  15      


Glu Ser Gln Pro Tyr Ser Gly Pro Arg Thr Pro Asp Gly Arg Glu Ile 
            20                  25                  30          


Val Phe Tyr Lys Val Ile Asp Tyr Ile Leu His Gly Lys Glu Glu Ile 
        35                  40                  45              


Lys Val Ile Pro Thr Pro Ser Ala Asp His Trp Ala Leu Ala Ser Gly 
    50                  55                  60                  


Leu Pro Ser Tyr Val Ala Glu Ser Gly Phe Ile Cys Asn Ile Met Asn 
65                  70                  75                  80  


Ala Ser Ala Asp Glu Met Phe Lys Phe Gln Glu Gly Ala Leu Asp Asp 
                85                  90                  95      


Ser Gly Trp Leu Ile Lys Asn Val Leu Ser Met Pro Ile Val Asn Lys 
            100                 105                 110         


Lys Glu Glu Ile Val Gly Val Ala Thr Phe Tyr Asn Arg Lys Asp Gly 
        115                 120                 125             


Lys Pro Phe Asp Glu Gln Asp Glu Val Leu Met Glu Ser Leu Thr Gln 
    130                 135                 140                 


Phe Leu Gly Trp Ser Val Met Asn Thr Asp Thr Tyr Asp Lys Met Asn 
145                 150                 155                 160 


Lys Leu Glu Asn Arg Lys Asp Ile Ala Gln Asp Met Val Leu Tyr His 
                165                 170                 175     


Val Lys Cys Asp Arg Asp Glu Ile Gln Leu Ile Leu Pro Thr Arg Ala 
            180                 185                 190         


Arg Leu Gly Lys Glu Pro Ala Asp Cys Asp Glu Asp Glu Leu Gly Glu 
        195                 200                 205             


Ile Leu Lys Glu Glu Leu Pro Gly Pro Thr Thr Phe Asp Ile Tyr Glu 
    210                 215                 220                 


Phe His Phe Ser Asp Leu Glu Cys Thr Glu Leu Asp Leu Val Lys Cys 
225                 230                 235                 240 


Gly Ile Gln Met Tyr Tyr Glu Leu Gly Val Val Arg Lys Phe Gln Ile 
                245                 250                 255     


Pro Gln Glu Val Leu Val Arg Phe Leu Phe Ser Ile Ser Lys Gly Tyr 
            260                 265                 270         


Arg Arg Ile Thr Tyr His Asn Trp Arg His Gly Phe Asn Val Ala Gln 
        275                 280                 285             


Thr Met Phe Thr Leu Leu Met Thr Gly Lys Leu Lys Ser Tyr Tyr Thr 
    290                 295                 300                 


Asp Leu Glu Ala Phe Ala Met Val Thr Ala Gly Leu Cys His Asp Ile 
305                 310                 315                 320 


Asp His Arg Gly Thr Asn Asn Leu Tyr Gln Met Lys Ser Gln Asn Pro 
                325                 330                 335     


Leu Ala Lys Leu His Gly Ser Ser Ile Leu Glu Arg His His Leu Glu 
            340                 345                 350         


Phe Gly Lys Phe Leu Leu Ser Glu Glu Thr Leu Asn Ile Tyr Gln Asn 
        355                 360                 365             


Leu Asn Arg Arg Gln His Glu His Val Ile His Leu Met Asp Ile Ala 
    370                 375                 380                 


Ile Ile Ala Thr Asp Leu Ala Leu Tyr Phe Lys Lys Arg Ala Met Phe 
385                 390                 395                 400 


Gln Lys Ile Val Asp Glu Ser Lys Asn Tyr Gln Asp Lys Lys Ser Trp 
                405                 410                 415     


Val Glu Tyr Leu Ser Leu Glu Thr Thr Arg Lys Glu Ile Val Met Ala 
            420                 425                 430         


Met Met Met Thr Ala Cys Asp Leu Ser Ala Ile Thr Lys Pro Trp Glu 
        435                 440                 445             


Val Gln Ser Lys Val Ala Leu Leu Val Ala Ala Glu Phe Trp Glu Gln 
    450                 455                 460                 


Gly Asp Leu Glu Arg Thr Val Leu Asp Gln Gln Pro Ile Pro Met Met 
465                 470                 475                 480 


Asp Arg Asn Lys Ala Ala Glu Leu Pro Lys Leu Gln Val Gly Phe Ile 
                485                 490                 495     


Asp Phe Val Cys Thr Phe Val Tyr Lys Glu Phe Ser Arg Phe His Glu 
            500                 505                 510         


Glu Ile Leu Pro Met Phe Asp Arg Leu Gln Asn Asn Arg Lys Glu Trp 
        515                 520                 525             


Lys Ala Leu Ala Asp Glu Tyr Glu Ala Lys Val Lys Ala Leu Glu Glu 
    530                 535                 540                 


Lys Glu Glu Glu Glu Arg Val Ala Ala Lys Lys Val Gly Thr Glu Ile 
545                 550                 555                 560 


Cys Asn Gly Gly Pro Ala Pro Lys Ser Ser Thr Cys Cys Ile Leu 
                565                 570                 575 


<210>  1845
<211>  636
<212>  PRT
<213>  Homo sapiens

<400>  1845

Met Ala Ala Ala Ala Leu Gly Ser Ser Ser Gly Ser Ala Ser Pro Ala 
1               5                   10                  15      


Val Ala Glu Leu Cys Gln Asn Thr Pro Glu Thr Phe Leu Glu Ala Ser 
            20                  25                  30          


Lys Leu Leu Leu Thr Tyr Ala Asp Asn Ile Leu Arg Asn Pro Asn Asp 
        35                  40                  45              


Glu Lys Tyr Arg Ser Ile Arg Ile Gly Asn Thr Ala Phe Ser Thr Arg 
    50                  55                  60                  


Leu Leu Pro Val Arg Gly Ala Val Glu Cys Leu Phe Glu Met Gly Phe 
65                  70                  75                  80  


Glu Glu Gly Glu Thr His Leu Ile Phe Pro Lys Lys Ala Ser Val Glu 
                85                  90                  95      


Gln Leu Gln Lys Ile Arg Asp Leu Ile Ala Ile Glu Arg Ser Ser Arg 
            100                 105                 110         


Leu Asp Gly Ser Asn Lys Ser His Lys Val Lys Ser Ser Gln Gln Pro 
        115                 120                 125             


Ala Ala Ser Thr Gln Leu Pro Thr Thr Pro Ser Ser Asn Pro Ser Gly 
    130                 135                 140                 


Leu Asn Gln His Thr Arg Asn Arg Gln Gly Gln Ser Ser Asp Pro Pro 
145                 150                 155                 160 


Ser Ala Ser Thr Val Ala Ala Asp Ser Ala Ile Leu Glu Val Leu Gln 
                165                 170                 175     


Ser Asn Ile Gln His Val Leu Val Tyr Glu Asn Pro Ala Leu Gln Glu 
            180                 185                 190         


Lys Ala Leu Ala Cys Ile Pro Val Gln Glu Leu Lys Arg Lys Ser Gln 
        195                 200                 205             


Glu Lys Leu Ser Arg Ala Arg Lys Leu Asp Lys Gly Ile Asn Ile Ser 
    210                 215                 220                 


Asp Glu Asp Phe Leu Leu Leu Glu Leu Leu His Trp Phe Lys Glu Glu 
225                 230                 235                 240 


Phe Phe His Trp Val Asn Asn Val Leu Cys Ser Lys Cys Gly Gly Gln 
                245                 250                 255     


Thr Arg Ser Arg Asp Arg Ser Leu Leu Pro Ser Asp Asp Glu Leu Lys 
            260                 265                 270         


Trp Gly Ala Lys Glu Val Glu Asp His Tyr Cys Asp Ala Cys Gln Phe 
        275                 280                 285             


Ser Asn Arg Phe Pro Arg Tyr Asn Asn Pro Glu Lys Leu Leu Glu Thr 
    290                 295                 300                 


Arg Cys Gly Arg Cys Gly Glu Trp Ala Asn Cys Phe Thr Leu Cys Cys 
305                 310                 315                 320 


Arg Ala Val Gly Phe Glu Ala Arg Tyr Val Trp Asp Tyr Thr Glu Leu 
                325                 330                 335     


Gln Arg Thr Leu Ser Leu Lys Leu Thr Thr Leu Lys Glu Ile Gly Lys 
            340                 345                 350         


Thr Phe Leu Arg Ile Ser Lys Arg Gln Lys Leu Ile Gln Val Val Asp 
        355                 360                 365             


Val Thr Trp Arg Tyr Ser Cys Lys His Glu Glu Val Ile Ala Arg Arg 
    370                 375                 380                 


Thr Lys Val Lys Glu Ala Leu Leu Arg Asp Thr Ile Asn Gly Leu Asn 
385                 390                 395                 400 


Lys Gln Arg Gln Leu Phe Leu Ser Glu Asn Arg Arg Lys Glu Leu Leu 
                405                 410                 415     


Gln Arg Ile Ile Val Glu Leu Val Glu Phe Ile Ser Pro Lys Thr Pro 
            420                 425                 430         


Lys Pro Gly Glu Leu Gly Gly Arg Ile Ser Gly Ser Val Ala Trp Arg 
        435                 440                 445             


Val Ala Arg Gly Glu Met Gly Leu Gln Arg Lys Glu Thr Leu Phe Ile 
    450                 455                 460                 


Pro Cys Glu Asn Glu Lys Ile Ser Lys Gln Leu His Leu Cys Tyr Asn 
465                 470                 475                 480 


Ile Val Lys Asp Arg Tyr Val Arg Val Ser Asn Asn Asn Gln Thr Ile 
                485                 490                 495     


Ser Gly Trp Glu Asn Gly Val Trp Lys Met Glu Ser Ile Phe Arg Lys 
            500                 505                 510         


Val Glu Thr Asp Trp His Met Val Tyr Leu Ala Arg Lys Glu Gly Ser 
        515                 520                 525             


Ser Phe Ala Tyr Ile Ser Trp Lys Phe Glu Cys Gly Ser Val Gly Leu 
    530                 535                 540                 


Lys Val Asp Ser Ile Ser Ile Arg Thr Ser Ser Gln Thr Phe Gln Thr 
545                 550                 555                 560 


Gly Thr Val Glu Trp Lys Leu Arg Ser Asp Thr Ala Gln Val Glu Leu 
                565                 570                 575     


Thr Gly Asp Asn Ser Leu His Ser Tyr Ala Asp Phe Ser Gly Ala Thr 
            580                 585                 590         


Glu Val Ile Leu Glu Ala Glu Leu Ser Arg Gly Asp Gly Asp Val Ala 
        595                 600                 605             


Trp Gln His Thr Gln Leu Phe Arg Gln Ser Leu Asn Asp His Glu Glu 
    610                 615                 620                 


Asn Cys Leu Glu Ile Ile Ile Lys Phe Ser Asp Leu 
625                 630                 635     


<210>  1846
<211>  612
<212>  PRT
<213>  Homo sapiens

<400>  1846

Met Arg Asn Pro Asn Asp Glu Lys Tyr Arg Ser Ile Arg Ile Gly Asn 
1               5                   10                  15      


Thr Ala Phe Ser Thr Arg Leu Leu Pro Val Arg Gly Ala Val Glu Cys 
            20                  25                  30          


Leu Phe Glu Met Gly Phe Glu Glu Gly Glu Thr His Leu Ile Phe Pro 
        35                  40                  45              


Lys Lys Ala Ser Val Glu Gln Leu Gln Lys Ile Arg Asp Leu Ile Ala 
    50                  55                  60                  


Ile Glu Arg Ser Ser Arg Leu Asp Gly Ser Asn Lys Ser His Lys Val 
65                  70                  75                  80  


Lys Ser Ser Gln Gln Pro Ala Ala Ser Thr Gln Leu Pro Thr Thr Pro 
                85                  90                  95      


Ser Ser Asn Pro Ser Gly Leu Asn Gln His Thr Arg Asn Arg Gln Gly 
            100                 105                 110         


Gln Ser Ser Asp Pro Pro Ser Ala Ser Thr Val Ala Ala Asp Ser Ala 
        115                 120                 125             


Ile Leu Glu Val Leu Gln Ser Asn Ile Gln His Val Leu Val Tyr Glu 
    130                 135                 140                 


Asn Pro Ala Leu Gln Glu Lys Ala Leu Ala Cys Ile Pro Val Gln Glu 
145                 150                 155                 160 


Leu Lys Arg Lys Ser Gln Glu Lys Leu Ser Arg Ala Arg Lys Leu Asp 
                165                 170                 175     


Lys Gly Ile Asn Ile Ser Asp Glu Asp Phe Leu Leu Leu Glu Leu Leu 
            180                 185                 190         


His Trp Phe Lys Glu Glu Phe Phe His Trp Val Asn Asn Val Leu Cys 
        195                 200                 205             


Ser Lys Cys Gly Gly Gln Thr Arg Ser Arg Asp Arg Ser Leu Leu Pro 
    210                 215                 220                 


Ser Asp Asp Glu Leu Lys Trp Gly Ala Lys Glu Val Glu Asp His Tyr 
225                 230                 235                 240 


Cys Asp Ala Cys Gln Phe Ser Asn Arg Phe Pro Arg Tyr Asn Asn Pro 
                245                 250                 255     


Glu Lys Leu Leu Glu Thr Arg Cys Gly Arg Cys Gly Glu Trp Ala Asn 
            260                 265                 270         


Cys Phe Thr Leu Cys Cys Arg Ala Val Gly Phe Glu Ala Arg Tyr Val 
        275                 280                 285             


Trp Asp Tyr Thr Asp His Val Trp Thr Glu Val Tyr Ser Pro Ser Gln 
    290                 295                 300                 


Gln Arg Trp Leu His Cys Asp Ala Cys Glu Asp Val Cys Asp Lys Pro 
305                 310                 315                 320 


Leu Leu Tyr Glu Ile Gly Trp Gly Lys Lys Leu Ser Tyr Val Ile Ala 
                325                 330                 335     


Phe Ser Lys Asp Glu Val Val Asp Val Thr Trp Arg Tyr Ser Cys Lys 
            340                 345                 350         


His Glu Glu Val Ile Ala Arg Arg Thr Lys Val Lys Glu Ala Leu Leu 
        355                 360                 365             


Arg Asp Thr Ile Asn Gly Leu Asn Lys Gln Arg Gln Leu Phe Leu Ser 
    370                 375                 380                 


Glu Asn Arg Arg Lys Glu Leu Leu Gln Arg Ile Ile Val Glu Leu Val 
385                 390                 395                 400 


Glu Phe Ile Ser Pro Lys Thr Pro Lys Pro Gly Glu Leu Gly Gly Arg 
                405                 410                 415     


Ile Ser Gly Ser Val Ala Trp Arg Val Ala Arg Gly Glu Met Gly Leu 
            420                 425                 430         


Gln Arg Lys Glu Thr Leu Phe Ile Pro Cys Glu Asn Glu Lys Ile Ser 
        435                 440                 445             


Lys Gln Leu His Leu Cys Tyr Asn Ile Val Lys Asp Arg Tyr Val Arg 
    450                 455                 460                 


Val Ser Asn Asn Asn Gln Thr Ile Ser Gly Trp Glu Asn Gly Val Trp 
465                 470                 475                 480 


Lys Met Glu Ser Ile Phe Arg Lys Val Glu Thr Asp Trp His Met Val 
                485                 490                 495     


Tyr Leu Ala Arg Lys Glu Gly Ser Ser Phe Ala Tyr Ile Ser Trp Lys 
            500                 505                 510         


Phe Glu Cys Gly Ser Val Gly Leu Lys Val Asp Ser Ile Ser Ile Arg 
        515                 520                 525             


Thr Ser Ser Gln Thr Phe Gln Thr Gly Thr Val Glu Trp Lys Leu Arg 
    530                 535                 540                 


Ser Asp Thr Ala Gln Val Glu Leu Thr Gly Asp Asn Ser Leu His Ser 
545                 550                 555                 560 


Tyr Ala Asp Phe Ser Gly Ala Thr Glu Val Ile Leu Glu Ala Glu Leu 
                565                 570                 575     


Ser Arg Gly Asp Gly Asp Val Ala Trp Gln His Thr Gln Leu Phe Arg 
            580                 585                 590         


Gln Ser Leu Asn Asp His Glu Glu Asn Cys Leu Glu Ile Ile Ile Lys 
        595                 600                 605             


Phe Ser Asp Leu 
    610         


<210>  1847
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  1847

Met Ala Ala Ala Ala Leu Gly Ser Ser Ser Gly Ser Ala Ser Pro Ala 
1               5                   10                  15      


Val Ala Glu Leu Cys Gln Asn Thr Pro Glu Thr Phe Leu Glu Ala Ser 
            20                  25                  30          


Lys Leu Leu Leu Thr Tyr Ala Asp Asn Ile Leu Arg Asn Pro Asn Asp 
        35                  40                  45              


Glu Lys Tyr Arg Ser Ile Arg Ile Gly Asn Thr Ala Phe Ser Thr Arg 
    50                  55                  60                  


Leu Leu Pro Val Arg Gly Ala Val Glu Cys Leu Phe Glu Met Gly Phe 
65                  70                  75                  80  


Glu Glu Gly Glu Thr His Leu Ile Phe Pro Lys Lys Ala Ser Val Glu 
                85                  90                  95      


Gln Leu Gln Lys Ile Arg Asp Leu Ile Ala Ile Glu Arg Ser Ser Arg 
            100                 105                 110         


Leu Asp Gly Ser Asn Lys Ser His Lys Val Lys Ser Ser Gln Gln Pro 
        115                 120                 125             


Ala Ala Ser Thr Gln Leu Pro Thr Thr Pro Ser Ser Asn Pro Ser Gly 
    130                 135                 140                 


Leu Asn Gln His Thr Arg Asn Arg Gln Gly Gln Ser Ser Asp Pro Pro 
145                 150                 155                 160 


Ser Ala Ser Thr Val Ala Ala Asp Ser Ala Ile Leu Glu Val Leu Gln 
                165                 170                 175     


Ser Asn Ile Gln His Val Leu Val Tyr Glu Asn Pro Ala Leu Gln Glu 
            180                 185                 190         


Lys Ala Leu Ala Cys Ile Pro Val Gln Glu Leu Lys Arg Lys Ser Gln 
        195                 200                 205             


Glu Lys Leu Ser Arg Ala Arg Lys Leu Asp Lys Gly Ile Asn Ile Ser 
    210                 215                 220                 


Asp Glu Asp Phe Leu Leu Leu Glu Leu Leu His Trp Phe Lys Glu Glu 
225                 230                 235                 240 


Phe Phe His Trp Val Asn Asn Val Leu Cys Ser Lys Cys Gly Gly Gln 
                245                 250                 255     


Thr Arg Ser Arg Asp Arg Ser Leu Leu Pro Ser Asp Asp Glu Leu Lys 
            260                 265                 270         


Trp Gly Ala Lys Glu Val Glu Asp His Tyr Cys Asp Ala Cys Gln Phe 
        275                 280                 285             


Ser Asn Arg Phe Pro Arg Tyr Asn Asn Pro Glu Lys Leu Leu Glu Thr 
    290                 295                 300                 


Arg Cys Gly Arg Cys Gly Glu Trp Ala Asn Cys Phe Thr Leu Cys Cys 
305                 310                 315                 320 


Arg Ala Val Gly Phe Glu Ala Arg Tyr Val Trp Asp Tyr Thr Asp His 
                325                 330                 335     


Val Trp Thr Glu Val Tyr Ser Pro Ser Gln Gln Arg Trp Leu His Cys 
            340                 345                 350         


Asp Ala Cys Glu Asp Val Cys Asp Lys Pro Leu Leu Tyr Glu Ile Gly 
        355                 360                 365             


Trp Gly Lys Lys Leu Ser Tyr Val Ile Ala Phe Ser Lys Asp Glu Val 
    370                 375                 380                 


Val Asp Val Thr Trp Arg Tyr Ser Cys Lys His Glu Glu Val Ile Ala 
385                 390                 395                 400 


Arg Arg Thr Lys Val Lys Glu Ala Leu Leu Arg Asp Thr Ile Asn Gly 
                405                 410                 415     


Leu Asn Lys Gln Arg Gln Leu Phe Leu Ser Glu Asn Arg Arg Lys Glu 
            420                 425                 430         


Leu Leu Gln Arg Ile Ile Val Glu Leu Val Glu Phe Ile Ser Pro Lys 
        435                 440                 445             


Thr Pro Lys Pro Gly Glu Leu Gly Gly Arg Ile Ser Gly Ser Val Ala 
    450                 455                 460                 


Trp Arg Val Ala Arg Gly Glu Met Gly Leu Gln Arg Lys Glu Thr Leu 
465                 470                 475                 480 


Phe Ile Pro Cys Glu Asn Glu Lys Ile Ser Lys Gln Leu His Leu Cys 
                485                 490                 495     


Tyr Asn Ile Val Lys Asp Arg Tyr Val Arg Val Ser Asn Asn Asn Gln 
            500                 505                 510         


Thr Ile Ser Gly Trp Glu Asn Gly Val Trp Lys Met Glu Ser Ile Phe 
        515                 520                 525             


Arg Lys Val Glu Thr Asp Trp His Met Ile Thr Val Phe Thr Pro Met 
    530                 535                 540                 


Leu Ile Phe Leu Val Pro Leu Lys Leu Phe Trp Lys Gln Asn 
545                 550                 555             


<210>  1848
<211>  712
<212>  PRT
<213>  Homo sapiens

<400>  1848

Met Glu Glu Asn Pro Thr Leu Glu Ser Glu Ala Trp Gly Ser Ser Arg 
1               5                   10                  15      


Glu Trp Leu Ala Pro Arg Glu Ala Arg Gly Ala Pro Cys Ser Ser Pro 
            20                  25                  30          


Gly Pro Ser Leu Ser Ser Val Leu Asn Glu Leu Pro Ser Ala Ala Thr 
        35                  40                  45              


Leu Arg Tyr Arg Asp Pro Gly Val Leu Pro Trp Gly Ala Leu Glu Glu 
    50                  55                  60                  


Glu Glu Glu Asp Gly Gly Arg Ser Arg Lys Ala Phe Thr Glu Val Thr 
65                  70                  75                  80  


Gln Thr Glu Leu Gln Asp Pro His Pro Ser Arg Glu Leu Pro Trp Pro 
                85                  90                  95      


Met Gln Ala Arg Arg Ala His Arg Gln Arg Asn Ala Ser Arg Asp Gln 
            100                 105                 110         


Val Val Tyr Gly Ser Gly Thr Lys Thr Asp Arg Trp Ala Arg Leu Leu 
        115                 120                 125             


Arg Arg Ser Lys Glu Lys Thr Lys Glu Gly Leu Arg Ser Leu Gln Pro 
    130                 135                 140                 


Trp Ala Trp Thr Leu Lys Arg Ile Gly Gly Gln Phe Gly Ala Gly Thr 
145                 150                 155                 160 


Glu Ser Tyr Phe Ser Leu Leu Arg Phe Leu Leu Leu Leu Asn Val Leu 
                165                 170                 175     


Ala Ser Val Leu Met Ala Cys Met Thr Leu Leu Pro Thr Trp Leu Gly 
            180                 185                 190         


Gly Ala Pro Pro Gly Pro Pro Gly Pro Asp Ile Ser Ser Pro Cys Gly 
        195                 200                 205             


Ser Tyr Asn Pro His Ser Gln Gly Leu Val Thr Phe Ala Thr Gln Leu 
    210                 215                 220                 


Phe Asn Leu Leu Ser Gly Glu Gly Tyr Leu Glu Trp Ser Pro Leu Phe 
225                 230                 235                 240 


Tyr Gly Phe Tyr Pro Pro Arg Pro Arg Leu Ala Val Thr Tyr Leu Cys 
                245                 250                 255     


Trp Ala Phe Ala Val Gly Leu Ile Cys Leu Leu Leu Ile Leu His Arg 
            260                 265                 270         


Ser Val Ser Gly Leu Lys Gln Thr Leu Leu Ala Glu Ser Glu Ala Leu 
        275                 280                 285             


Thr Ser Tyr Ser His Arg Val Phe Ser Ala Trp Asp Phe Gly Leu Cys 
    290                 295                 300                 


Gly Asp Val His Val Arg Leu Arg Gln Arg Ile Ile Leu Tyr Glu Leu 
305                 310                 315                 320 


Lys Val Glu Leu Glu Glu Thr Val Val Arg Arg Gln Ala Ala Val Arg 
                325                 330                 335     


Thr Leu Gly Gln Gln Ala Arg Val Trp Leu Val Arg Val Leu Leu Asn 
            340                 345                 350         


Leu Leu Val Val Ala Leu Leu Gly Ala Ala Phe Tyr Gly Val Tyr Trp 
        355                 360                 365             


Ala Thr Gly Cys Thr Val Glu Leu Gln Glu Met Pro Leu Val Gln Glu 
    370                 375                 380                 


Leu Pro Leu Leu Lys Leu Gly Val Asn Tyr Leu Pro Ser Ile Phe Ile 
385                 390                 395                 400 


Ala Gly Val Asn Phe Val Leu Pro Pro Val Phe Lys Leu Ile Ala Pro 
                405                 410                 415     


Leu Glu Gly Tyr Thr Arg Ser Arg Gln Ile Val Phe Ile Leu Leu Arg 
            420                 425                 430         


Thr Val Phe Leu Arg Leu Ala Ser Leu Val Val Leu Leu Phe Ser Leu 
        435                 440                 445             


Trp Asn Gln Ile Thr Cys Gly Gly Asp Ser Glu Ala Glu Asp Cys Lys 
    450                 455                 460                 


Thr Cys Gly Tyr Asn Tyr Lys Gln Leu Pro Cys Trp Glu Thr Val Leu 
465                 470                 475                 480 


Gly Gln Glu Met Tyr Lys Leu Leu Leu Phe Asp Leu Leu Thr Val Leu 
                485                 490                 495     


Ala Val Ala Leu Leu Ile Gln Phe Pro Arg Lys Leu Leu Cys Gly Leu 
            500                 505                 510         


Cys Pro Gly Ala Leu Gly Arg Leu Ala Gly Thr Gln Glu Phe Gln Val 
        515                 520                 525             


Pro Asp Glu Val Leu Gly Leu Ile Tyr Ala Gln Thr Val Val Trp Val 
    530                 535                 540                 


Gly Ser Phe Phe Cys Pro Leu Leu Pro Leu Leu Asn Thr Val Lys Phe 
545                 550                 555                 560 


Leu Leu Leu Phe Tyr Leu Lys Lys Leu Thr Leu Phe Ser Thr Cys Ser 
                565                 570                 575     


Pro Ala Ala Arg Thr Phe Arg Ala Ser Ala Ala Asn Phe Phe Phe Pro 
            580                 585                 590         


Leu Val Leu Leu Leu Gly Leu Ala Ile Ser Ser Val Pro Leu Leu Tyr 
        595                 600                 605             


Ser Ile Phe Leu Ile Pro Pro Ser Lys Leu Cys Gly Pro Phe Arg Gly 
    610                 615                 620                 


Gln Ser Ser Ile Trp Ala Gln Ile Pro Glu Ser Ile Ser Ser Leu Pro 
625                 630                 635                 640 


Glu Thr Thr Gln Asn Phe Leu Phe Phe Leu Gly Thr Gln Ala Phe Ala 
                645                 650                 655     


Val Pro Leu Leu Leu Ile Ser Ser Ile Leu Met Ala Tyr Thr Val Ala 
            660                 665                 670         


Leu Ala Asn Ser Tyr Gly Arg Leu Ile Ser Glu Leu Lys Arg Gln Arg 
        675                 680                 685             


Glu Thr Glu Ala Gln Asn Lys Val Phe Leu Ala Arg Arg Ala Val Ala 
    690                 695                 700                 


Leu Thr Ser Thr Lys Pro Ala Leu 
705                 710         


<210>  1849
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  1849

Met Asn Lys Arg Asp Tyr Met Asn Thr Ser Val Gln Glu Pro Pro Leu 
1               5                   10                  15      


Asp Tyr Ser Phe Arg Ser Ile His Val Ile Gln Asp Leu Val Asn Glu 
            20                  25                  30          


Glu Pro Arg Thr Gly Leu Arg Pro Leu Lys Arg Ser Lys Ser Gly Lys 
        35                  40                  45              


Ser Leu Thr Gln Ser Leu Trp Leu Asn Asn Asn Val Leu Asn Asp Leu 
    50                  55                  60                  


Arg Asp Phe Asn Gln Val Ala Ser Gln Leu Leu Glu His Pro Glu Asn 
65                  70                  75                  80  


Leu Ala Trp Ile Asp Leu Ser Phe Asn Asp Leu Thr Ser Ile Asp Pro 
                85                  90                  95      


Val Leu Thr Thr Phe Phe Asn Leu Ser Val Leu Tyr Leu His Gly Asn 
            100                 105                 110         


Ser Ile Gln Arg Leu Gly Glu Val Asn Lys Leu Ala Val Leu Pro Arg 
        115                 120                 125             


Leu Arg Ser Leu Thr Leu His Gly Asn Pro Met Glu Glu Glu Lys Gly 
    130                 135                 140                 


Tyr Arg Val Pro Gly Ser Val Glu Met Pro His Arg Pro Pro 
145                 150                 155             


<210>  1850
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  1850

Met Gly Thr Pro Trp Arg Lys Arg Lys Gly Ile Ala Gly Pro Gly Leu 
1               5                   10                  15      


Pro Asp Leu Ser Cys Ala Leu Val Leu Gln Pro Arg Ala Gln Val Gly 
            20                  25                  30          


Thr Met Ser Pro Ala Ile Ala Leu Ala Phe Leu Pro Leu Val Val Thr 
        35                  40                  45              


Leu Leu Val Arg Tyr Arg His Tyr Phe Arg Leu Leu Val Arg Thr Val 
    50                  55                  60                  


Leu Leu Arg Ser Leu Arg Asp Cys Leu Ser Gly Leu Arg Ile Glu Glu 
65                  70                  75                  80  


Arg Ala Phe Ser Tyr Val Leu Thr His Ala Leu Pro Gly Asp Pro Gly 
                85                  90                  95      


His Ile Leu Thr Thr Leu Asp His Trp Ser Ser Arg Cys Glu Tyr Leu 
            100                 105                 110         


Ser His Met Gly Pro Val Lys Gly Gln Ile Leu Met Arg Leu Val Glu 
        115                 120                 125             


Glu Lys Ala Pro Ala Cys Val Leu Glu Leu Gly Thr Tyr Cys Gly Tyr 
    130                 135                 140                 


Ser Thr Leu Leu Ile Ala Arg Ala Leu Pro Pro Gly Gly Arg Leu Leu 
145                 150                 155                 160 


Thr Val Glu Arg Asp Pro Arg Thr Ala Ala Val Ala Glu Lys Leu Ile 
                165                 170                 175     


Arg Leu Ala Gly Phe Asp Glu His Met Val Glu Leu Ile Val Gly Ser 
            180                 185                 190         


Ser Glu Asp Val Ile Pro Cys Leu Arg Thr Gln Tyr Gln Leu Ser Arg 
        195                 200                 205             


Ala Asp Leu Val Leu Leu Ala His Arg Pro Arg Cys Tyr Leu Arg Asp 
    210                 215                 220                 


Leu Gln Leu Leu Glu Ala His Ala Leu Leu Pro Ala Gly Ala Thr Val 
225                 230                 235                 240 


Leu Ala Asp His Val Leu Phe Pro Gly Ala Pro Arg Phe Leu Gln Tyr 
                245                 250                 255     


Ala Lys Ser Cys Gly Arg Tyr Arg Cys Arg Leu His His Thr Gly Leu 
            260                 265                 270         


Pro Asp Phe Pro Ala Ile Lys Asp Gly Ile Ala Gln Leu Thr Tyr Ala 
        275                 280                 285             


Gly Pro Gly 
    290     


<210>  1851
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  1851

Met Gly Thr Pro Trp Arg Lys Arg Lys Gly Ile Ala Gly Pro Gly Leu 
1               5                   10                  15      


Pro Asp Leu Ser Cys Ala Leu Val Leu Gln Pro Arg Ala Gln Val Gly 
            20                  25                  30          


Thr Met Ser Pro Ala Ile Ala Leu Ala Phe Leu Pro Leu Val Val Thr 
        35                  40                  45              


Leu Leu Val Arg Tyr Arg His Tyr Phe Arg Leu Leu Val Arg Thr Val 
    50                  55                  60                  


Leu Leu Arg Ser Leu Arg Asp Cys Leu Ser Gly Leu Arg Ile Glu Glu 
65                  70                  75                  80  


Arg Ala Phe Ser Tyr Val Leu Thr His Ala Leu Pro Gly Asp Pro Gly 
                85                  90                  95      


His Ile Leu Thr Thr Leu Asp His Trp Ser Ser Arg Cys Glu Tyr Leu 
            100                 105                 110         


Ser His Met Gly Pro Val Lys Gly Gln Ile Leu Met Arg Leu Val Glu 
        115                 120                 125             


Glu Lys Ala Pro Ala Cys Val Leu Glu Leu Gly Thr Tyr Cys Gly Tyr 
    130                 135                 140                 


Ser Thr Leu Leu Ile Ala Arg Ala Leu Pro Pro Gly Gly Arg Leu Leu 
145                 150                 155                 160 


Thr Val Glu Arg Asp Pro Arg Thr Ala Ala Val Ala Glu Lys Leu Ile 
                165                 170                 175     


Arg Leu Ala Gly Phe Asp Glu His Met Val Glu Leu Ile Val Gly Ser 
            180                 185                 190         


Ser Glu Asp Val Ile Pro Cys Leu Arg Thr Gln Tyr Gln Leu Ser Arg 
        195                 200                 205             


Ala Asp Leu Val Leu Leu Ala His Arg Pro Arg Cys Tyr Leu Arg Asp 
    210                 215                 220                 


Leu Gln Leu Leu Glu Ala His Ala Leu Leu Pro Ala Gly Ala Thr Val 
225                 230                 235                 240 


Leu Ala Asp His Val Leu Phe Pro Gly Ala Pro Arg Phe Leu Gln Tyr 
                245                 250                 255     


Ala Lys Ser Cys Gly Arg Tyr Arg Cys Arg Leu His His Thr Gly Leu 
            260                 265                 270         


Pro Asp Phe Pro Ala Ile Lys Asp Gly Ile Ala Gln Leu Thr Tyr Ala 
        275                 280                 285             


Gly Pro Gly 
    290     


<210>  1852
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  1852

Met Gly Thr Pro Trp Arg Lys Arg Lys Gly Ile Ala Gly Pro Gly Leu 
1               5                   10                  15      


Pro Asp Leu Ser Cys Ala Leu Val Leu Gln Pro Ser Leu Arg Asp Cys 
            20                  25                  30          


Leu Ser Gly Leu Arg Ile Glu Glu Arg Ala Phe Ser Tyr Val Leu Thr 
        35                  40                  45              


His Ala Leu Pro Gly Asp Pro Gly His Ile Leu Thr Thr Leu Asp His 
    50                  55                  60                  


Trp Ser Ser Arg Cys Glu Tyr Leu Ser His Met Gly Pro Val Lys Gly 
65                  70                  75                  80  


Gln Ile Leu Met Arg Leu Val Glu Glu Lys Ala Pro Ala Cys Val Leu 
                85                  90                  95      


Glu Leu Gly Thr Tyr Cys Gly Tyr Ser Thr Leu Leu Ile Ala Arg Ala 
            100                 105                 110         


Leu Pro Pro Gly Gly Arg Leu Leu Thr Val Glu Arg Asp Pro Arg Thr 
        115                 120                 125             


Ala Ala Val Ala Glu Lys Leu Ile Arg Leu Ala Gly Phe Asp Glu His 
    130                 135                 140                 


Met Val Glu Leu Ile Val Gly Ser Ser Glu Asp Val Ile Pro Cys Leu 
145                 150                 155                 160 


Arg Thr Gln Tyr Gln Leu Ser Arg Ala Asp Leu Val Leu Leu Ala His 
                165                 170                 175     


Arg Pro Arg Cys Tyr Leu Arg Asp Leu Gln Leu Leu Glu Ala His Ala 
            180                 185                 190         


Leu Leu Pro Ala Gly Ala Thr Val Leu Ala Asp His Val Leu Phe Pro 
        195                 200                 205             


Gly Ala Pro Arg Phe Leu Gln Tyr Ala Lys Ser Cys Gly Arg Tyr Arg 
    210                 215                 220                 


Cys Arg Leu His His Thr Gly Leu Pro Asp Phe Pro Ala Ile Lys Asp 
225                 230                 235                 240 


Gly Ile Ala Gln Leu Thr Tyr Ala Gly Pro Gly 
                245                 250     


<210>  1853
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  1853

Met Ala Val Asn Lys Gly Leu Thr Leu Leu Asp Gly Asp Leu Pro Glu 
1               5                   10                  15      


Gln Glu Asn Val Leu Gln Arg Val Leu Gln Leu Pro Val Val Ser Gly 
            20                  25                  30          


Thr Cys Glu Cys Phe Gln Lys Thr Tyr Thr Ser Thr Lys Glu Ala His 
        35                  40                  45              


Pro Leu Val Ala Ser Val Cys Asn Ala Tyr Glu Lys Gly Val Gln Ser 
    50                  55                  60                  


Ala Ser Ser Leu Ala Ala Trp Ser Met Glu Pro Val Val Arg Arg Leu 
65                  70                  75                  80  


Ser Thr Gln Phe Thr Ala Ala Asn Glu Leu Ala Cys Arg Gly Leu Asp 
                85                  90                  95      


His Leu Glu Glu Lys Ile Pro Ala Leu Gln Tyr Pro Pro Glu Lys Ile 
            100                 105                 110         


Ala Ser Glu Leu Lys Asp Thr Ile Ser Thr Arg Leu Arg Ser Ala Arg 
        115                 120                 125             


Asn Ser Ile Ser Val Pro Ile Ala Ser Thr Ser Asp Lys Val Leu Gly 
    130                 135                 140                 


Ala Ala Leu Ala Gly Cys Glu Leu Ala Trp Gly Val Ala Arg Asp Thr 
145                 150                 155                 160 


Ala Glu Phe Ala Ala Asn Thr Arg Ala Gly Arg Leu Ala Ser Gly Gly 
                165                 170                 175     


Ala Asp Leu Ala Leu Gly Ser Ile Glu Lys Val Val Glu Tyr Leu Leu 
            180                 185                 190         


Pro Pro Asp Lys Glu Glu Ser Ala Pro Ala Pro Gly His Gln Gln Ala 
        195                 200                 205             


Gln Lys Ser Pro Lys Ala Lys Pro Ser Leu Leu Ser Arg Val Gly Ala 
    210                 215                 220                 


Leu Thr Asn Thr Leu Ser Arg Tyr Thr Val Gln Thr Met Ala Arg Ala 
225                 230                 235                 240 


Leu Glu Gln Gly His Thr Val Ala Met Trp Ile Pro Gly Val Val Pro 
                245                 250                 255     


Leu Ser Ser Leu Ala Gln Trp Gly Ala Ser Val Ala Met Gln Ala Val 
            260                 265                 270         


Ser Arg Arg Arg Ser Glu Val Arg Val Pro Trp Leu His Ser Leu Ala 
        275                 280                 285             


Ala Ala Gln Glu Glu Asp His Glu Asp Gln Thr Asp Thr Glu Gly Glu 
    290                 295                 300                 


Asp Thr Glu Glu Glu Glu Glu Leu Glu Thr Glu Glu Asn Lys Phe Ser 
305                 310                 315                 320 


Glu Val Ala Ala Leu Pro Gly Pro Arg Gly Leu Leu Gly Gly Val Ala 
                325                 330                 335     


His Thr Leu Gln Lys Thr Leu Gln Thr Thr Ile Ser Ala Val Thr Trp 
            340                 345                 350         


Ala Pro Ala Ala Val Leu Gly Met Ala Gly Arg Val Leu His Leu Thr 
        355                 360                 365             


Pro Ala Pro Ala Val Ser Ser Thr Lys Gly Arg Ala Met Ser Leu Ser 
    370                 375                 380                 


Asp Ala Leu Lys Gly Val Thr Asp Asn Val Val Asp Thr Val Val His 
385                 390                 395                 400 


Tyr Val Pro Leu Pro Arg Leu Ser Leu Met Glu Pro Glu Ser Glu Phe 
                405                 410                 415     


Arg Asp Ile Asp Asn Pro Pro Ala Glu Val Glu Arg Arg Glu Ala Glu 
            420                 425                 430         


Arg Arg Ala Ser Gly Ala Pro Ser Ala Gly Pro Glu Pro Ala Pro Arg 
        435                 440                 445             


Leu Ala Gln Pro Arg Arg Ser Leu Arg Ser Ala Gln Ser Pro Gly Ala 
    450                 455                 460                 


Pro Pro Gly Pro Gly Leu Glu Asp Glu Val Ala Thr Pro Ala Ala Pro 
465                 470                 475                 480 


Arg Pro Gly Phe Pro Ala Val Pro Arg Glu Lys Pro Lys Arg Arg Val 
                485                 490                 495     


Ser Asp Ser Phe Phe Arg Pro Ser Val Met Glu Pro Ile Leu Gly Arg 
            500                 505                 510         


Thr His Tyr Ser Gln Leu Arg Lys Lys Ser 
        515                 520         


<210>  1854
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  1854

Met Lys Arg Trp Gln Ile Phe Val Leu Trp Val Phe Trp Val Leu Ile 
1               5                   10                  15      


Leu Trp Leu Met Thr Pro Tyr Leu Asp Leu Thr Pro Glu Ser Ala Pro 
            20                  25                  30          


Gln Glu Lys Arg Met Tyr Leu Val Pro Gln His Cys Asp Cys Pro Trp 
        35                  40                  45              


Phe Ser Ser Gly Lys Cys Gly Cys Pro Ser Glu Thr Leu Asn Cys Ser 
    50                  55                  60                  


Ser Cys His His Thr Ala Asp Glu Trp Asn Trp Leu Asp Ala Cys Ser 
65                  70                  75                  80  


Arg Lys Thr Met Gly Tyr Leu Met Arg Thr Arg Glu Ser Met Thr Ser 
                85                  90                  95      


Asp Thr Val Leu Trp Trp Leu Gly Met Asn Ser Gly Ser Glu Leu Gly 
            100                 105                 110         


Lys Leu Trp Arg Lys Leu Phe Lys Gly Ile Pro Arg Leu Ser Val Ser 
        115                 120                 125             


His Phe Asp Phe Tyr Cys Gly Thr Cys Val Leu Leu Gly Arg Pro Gln 
    130                 135                 140                 


Ile Pro Gln Gly Ser Ser Leu Gly Asn Asp Ile Asp Gln Tyr Pro Val 
145                 150                 155                 160 


Val Phe Arg Asn Ala Ser Asp Gln Gly Ser Trp Met Gln Leu Glu Met 
                165                 170                 175     


Leu Leu Arg Lys Leu Ser Asp Leu Val Trp Thr Ser Asp Ala Leu Ser 
            180                 185                 190         


Asp Lys Ile Leu Glu Asp Gly Leu Val Pro 
        195                 200         


<210>  1855
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  1855

Met Glu Glu Gly Gly Asn Leu Gly Gly Leu Ile Lys Met Val His Leu 
1               5                   10                  15      


Leu Val Leu Ser Gly Ala Trp Gly Met Gln Met Trp Val Thr Phe Val 
            20                  25                  30          


Ser Gly Phe Leu Leu Phe Arg Ser Leu Pro Arg His Thr Phe Gly Leu 
        35                  40                  45              


Val Gln Ser Lys Leu Phe Pro Phe Tyr Phe His Ile Ser Met Gly Cys 
    50                  55                  60                  


Ala Phe Ile Asn Leu Cys Ile Leu Ala Ser Gln His Ala Trp Ala Gln 
65                  70                  75                  80  


Leu Thr Phe Trp Glu Ala Ser Gln Leu Tyr Leu Leu Phe Leu Ser Leu 
                85                  90                  95      


Thr Leu Ala Thr Val Asn Ala Arg Trp Leu Glu Pro Arg Thr Thr Ala 
            100                 105                 110         


Ala Met Trp Ala Leu Gln Thr Val Glu Lys Glu Arg Gly Leu Gly Gly 
        115                 120                 125             


Glu Val Pro Gly Ser His Gln Gly Pro Asp Pro Tyr Arg Gln Leu Arg 
    130                 135                 140                 


Glu Lys Asp Pro Lys Tyr Ser Ala Leu Arg Gln Asn Phe Phe Arg Tyr 
145                 150                 155                 160 


His Gly Leu Ser Ser Leu Cys Asn Leu Gly Cys Val Leu Ser Asn Gly 
                165                 170                 175     


Leu Cys Leu Ala Gly Leu Ala Leu Glu Ile Arg Ser Leu 
            180                 185                 


<210>  1856
<211>  2481
<212>  PRT
<213>  Homo sapiens

<400>  1856

Met Glu Gln Ser Pro Pro Pro Ala Pro Glu Pro Thr Gln Gly Pro Thr 
1               5                   10                  15      


Pro Ala Arg Ser Arg Arg Arg Arg Glu Pro Glu Ser Pro Pro Ala Ser 
            20                  25                  30          


Ala Pro Ile Pro Leu Phe Gly Ala Asp Thr Ile Gly Gln Arg Ser Pro 
        35                  40                  45              


Asp Gly Pro Val Leu Ser Lys Ala Glu Phe Val Glu Lys Val Arg Gln 
    50                  55                  60                  


Ser Asn Gln Ala Cys His Asp Gly Asp Phe His Thr Ala Ile Val Leu 
65                  70                  75                  80  


Tyr Asn Glu Ala Leu Ala Val Asp Pro Gln Asn Cys Ile Leu Tyr Ser 
                85                  90                  95      


Asn Arg Ser Ala Ala Tyr Met Lys Ile Gln Gln Tyr Asp Lys Ala Leu 
            100                 105                 110         


Asp Asp Ala Ile Lys Ala Arg Leu Leu Asn Pro Lys Trp Pro Lys Ala 
        115                 120                 125             


Tyr Phe Arg Gln Gly Val Ala Leu Gln Tyr Leu Gly Arg His Ala Asp 
    130                 135                 140                 


Ala Leu Ala Ala Phe Ala Ser Gly Leu Ala Gln Asp Pro Lys Ser Leu 
145                 150                 155                 160 


Gln Leu Leu Val Gly Met Val Glu Ala Ala Met Lys Ser Pro Met Arg 
                165                 170                 175     


Asp Ser Leu Glu Pro Thr Tyr Gln Gln Leu Gln Lys Met Lys Leu Asp 
            180                 185                 190         


Lys Ser Pro Phe Val Val Val Ser Val Val Gly Gln Glu Leu Leu Thr 
        195                 200                 205             


Ala Gly His His Gly Ala Ser Val Val Val Leu Glu Ala Ala Leu Lys 
    210                 215                 220                 


Ile Gly Thr Cys Ser Leu Lys Leu Arg Gly Ser Val Phe Ser Ala Leu 
225                 230                 235                 240 


Ser Ser Ala Tyr Trp Ser Leu Gly Asn Thr Glu Lys Ser Thr Gly Tyr 
                245                 250                 255     


Met Gln Gln Asp Leu Asp Val Ala Lys Thr Leu Gly Asp Gln Thr Gly 
            260                 265                 270         


Glu Cys Arg Ala His Gly Asn Leu Gly Ser Ala Phe Phe Ser Lys Gly 
        275                 280                 285             


Asn Tyr Arg Glu Ala Leu Thr Asn His Arg His Gln Leu Val Leu Ala 
    290                 295                 300                 


Met Lys Leu Lys Asp Arg Glu Ala Ala Ser Ser Ala Leu Ser Ser Leu 
305                 310                 315                 320 


Gly His Val Tyr Thr Ala Ile Gly Asp Tyr Pro Asn Ala Leu Ala Ser 
                325                 330                 335     


His Lys Gln Cys Val Leu Leu Ala Lys Gln Ser Lys Asp Glu Leu Ser 
            340                 345                 350         


Glu Ala Arg Glu Leu Gly Asn Met Gly Ala Val Tyr Ile Ala Met Gly 
        355                 360                 365             


Asp Phe Glu Asn Ala Val Gln Cys His Glu Gln His Leu Lys Ile Ala 
    370                 375                 380                 


Lys Asp Leu Gly Asn Lys Arg Glu Glu Ala Arg Ala Tyr Ser Asn Leu 
385                 390                 395                 400 


Gly Ser Ala Tyr His Tyr Arg Arg Asn Phe Asp Lys Ala Met Ser Tyr 
                405                 410                 415     


His Asn Tyr Val Leu Glu Leu Ala Gln Glu Leu Met Glu Lys Ala Ile 
            420                 425                 430         


Glu Met Arg Ala Tyr Ala Gly Leu Gly His Ala Ala Arg Cys Met Gln 
        435                 440                 445             


Asp Leu Glu Arg Ala Lys Gln Tyr His Glu Gln Gln Leu Gly Ile Ala 
    450                 455                 460                 


Glu Asp Leu Lys Asp Arg Ala Ala Glu Gly Arg Ala Ser Ser Asn Leu 
465                 470                 475                 480 


Gly Ile Ile His Gln Met Lys Gly Asp Tyr Asp Thr Ala Leu Lys Leu 
                485                 490                 495     


His Lys Thr His Leu Cys Ile Ala Gln Glu Leu Ser Asp Tyr Ala Ala 
            500                 505                 510         


Gln Gly Arg Ala Tyr Gly Asn Met Gly Asn Ala Tyr Asn Ala Leu Gly 
        515                 520                 525             


Met Tyr Asp Gln Ala Val Lys Tyr His Arg Gln Glu Leu Gln Ile Ser 
    530                 535                 540                 


Met Glu Val Asn Asp Arg Ala Ser Gln Ala Ser Thr His Gly Asn Leu 
545                 550                 555                 560 


Ala Val Ala Tyr Gln Ala Leu Gly Ala His Asp Arg Ala Leu Gln His 
                565                 570                 575     


Tyr Gln Asn His Leu Asn Ile Ala Arg Glu Leu Arg Asp Ile Gln Ser 
            580                 585                 590         


Glu Ala Arg Ala Leu Ser Asn Leu Gly Asn Phe His Cys Ser Arg Gly 
        595                 600                 605             


Glu Tyr Val Gln Ala Ala Pro Tyr Tyr Glu Gln Tyr Leu Arg Leu Ala 
    610                 615                 620                 


Pro Asp Leu Gln Asp Met Glu Gly Glu Gly Lys Val Cys His Asn Leu 
625                 630                 635                 640 


Gly Tyr Ala His Tyr Cys Leu Gly Asn Tyr Gln Glu Ala Val Lys Tyr 
                645                 650                 655     


Tyr Glu Gln Asp Leu Ala Leu Ala Lys Asp Leu His Asp Lys Leu Ser 
            660                 665                 670         


Gln Ala Lys Ala Tyr Cys Asn Leu Gly Leu Ala Phe Lys Ala Leu Leu 
        675                 680                 685             


Asn Phe Ser Lys Ala Glu Glu Cys Gln Lys Tyr Leu Leu Ser Leu Ala 
    690                 695                 700                 


Gln Ser Leu Asn Asn Ser Gln Ala Lys Phe Arg Ala Leu Gly Asn Leu 
705                 710                 715                 720 


Gly Asp Ile Phe Ile Cys Lys Lys Asp Ile Asn Gly Ala Ile Lys Phe 
                725                 730                 735     


Tyr Glu Gln Gln Leu Gly Leu Ala His Gln Val Lys Asp Arg Arg Leu 
            740                 745                 750         


Glu Ala Ser Ala Tyr Ala Ala Leu Gly Thr Ala Tyr Arg Met Ile Gln 
        755                 760                 765             


Lys Tyr Asp Lys Ala Leu Gly Tyr His Thr Gln Glu Leu Glu Val Tyr 
    770                 775                 780                 


Gln Glu Leu Ser Asp Leu Pro Gly Glu Cys Arg Ala His Gly His Leu 
785                 790                 795                 800 


Ala Ala Val Tyr Met Ala Leu Gly Lys Tyr Thr Met Ala Phe Lys Cys 
                805                 810                 815     


Tyr Glu Glu Gln Leu Asp Leu Gly Gln Lys Leu Lys Asp Pro Ser Leu 
            820                 825                 830         


Glu Ala Gln Val Tyr Gly Asn Met Gly Ile Thr Lys Met Asn Met Asn 
        835                 840                 845             


Val Met Glu Glu Ala Ile Gly Tyr Phe Glu Gln Gln Leu Ala Met Leu 
    850                 855                 860                 


Gln Gln Leu Ser Gly Asn Glu Ser Val Leu Asp Arg Gly Arg Ala Tyr 
865                 870                 875                 880 


Gly Asn Leu Gly Asp Cys Tyr Glu Ala Leu Gly Asp Tyr Glu Glu Ala 
                885                 890                 895     


Ile Lys Tyr Tyr Glu Gln Tyr Leu Ser Val Ala Gln Ser Leu Asn Arg 
            900                 905                 910         


Met Gln Asp Gln Ala Lys Ala Tyr Arg Gly Leu Gly Asn Gly His Arg 
        915                 920                 925             


Ala Met Gly Ser Leu Gln Gln Ala Leu Val Cys Phe Glu Lys Arg Leu 
    930                 935                 940                 


Val Val Ala His Glu Leu Gly Glu Ala Phe Asn Lys Ala Gln Ala Tyr 
945                 950                 955                 960 


Gly Glu Leu Gly Ser Leu His Ser Gln Leu Gly Asn Tyr Glu Gln Ala 
                965                 970                 975     


Ile Ser Cys Leu Glu Arg Gln Leu Asn Ile Ala Arg Asp Met Lys Asp 
            980                 985                 990         


Arg Ala Leu Glu Ser Asp Ala Ala  Cys Gly Leu Gly Gly  Val Tyr Gln 
        995                 1000                 1005             


Gln Met  Gly Glu Tyr Asp Thr  Ala Leu Gln Tyr His  Gln Leu Asp 
    1010                 1015                 1020             


Leu Gln  Ile Ala Glu Glu Thr  Asn Asn Pro Thr Cys  Gln Gly Arg 
    1025                 1030                 1035             


Ala Tyr  Gly Asn Leu Gly Leu  Thr Tyr Glu Ser Leu  Gly Thr Phe 
    1040                 1045                 1050             


Glu Arg  Ala Val Val Tyr Gln  Glu Gln His Leu Ser  Ile Ala Ala 
    1055                 1060                 1065             


Gln Met  Asn Asp Leu Ala Ala  Lys Thr Val Ser Tyr  Ser Ser Leu 
    1070                 1075                 1080             


Gly Arg  Thr His His Ala Leu  Gln Asn Tyr Ser Gln  Ala Val Met 
    1085                 1090                 1095             


Tyr Leu  Gln Glu Gly Leu Arg  Leu Ala Glu Gln Leu  Gly Arg Arg 
    1100                 1105                 1110             


Glu Asp  Glu Ala Lys Ile Arg  His Gly Leu Gly Leu  Ser Leu Trp 
    1115                 1120                 1125             


Ala Ser  Gly Asn Leu Glu Glu  Ala Gln His Gln Leu  Tyr Arg Ala 
    1130                 1135                 1140             


Ser Ala  Leu Phe Glu Thr Ile  Arg His Glu Ala Gln  Leu Ser Thr 
    1145                 1150                 1155             


Asp Tyr  Lys Leu Ser Leu Phe  Asp Leu Gln Thr Ser  Ser Tyr Gln 
    1160                 1165                 1170             


Ala Leu  Gln Arg Val Leu Val  Ser Leu Gly His His  Asp Glu Ala 
    1175                 1180                 1185             


Leu Ala  Val Ala Glu Arg Gly  Arg Thr Arg Ala Phe  Ala Asp Leu 
    1190                 1195                 1200             


Leu Val  Glu Arg Gln Thr Gly  Gln Gln Asp Ser Asp  Pro Tyr Ser 
    1205                 1210                 1215             


Pro Val  Thr Ile Asp Gln Ile  Leu Glu Met Val Asn  Gly Gln Arg 
    1220                 1225                 1230             


Gly Leu  Val Leu Tyr Tyr Ser  Leu Ala Ala Gly Tyr  Leu Tyr Ser 
    1235                 1240                 1245             


Trp Leu  Leu Ala Pro Gly Ala  Gly Ile Val Lys Phe  His Glu His 
    1250                 1255                 1260             


Tyr Leu  Gly Glu Asn Thr Val  Glu Asn Ser Ser Asp  Phe Gln Ala 
    1265                 1270                 1275             


Ser Ser  Ser Val Thr Leu Pro  Thr Ala Thr Gly Ser  Ala Leu Glu 
    1280                 1285                 1290             


Gln His  Ile Ala Ser Val Arg  Glu Ala Leu Gly Val  Glu Ser His 
    1295                 1300                 1305             


Tyr Ser  Arg Ala Cys Ala Ser  Ser Glu Thr Glu Ser  Glu Ala Gly 
    1310                 1315                 1320             


Asp Ile  Met Asp Gln Gln Phe  Glu Glu Met Asn Asn  Lys Leu Asn 
    1325                 1330                 1335             


Ser Val  Thr Asp Pro Thr Gly  Phe Leu Arg Met Val  Arg Arg Asn 
    1340                 1345                 1350             


Asn Leu  Phe Asn Arg Ser Cys  Gln Ser Met Thr Ser  Leu Phe Ser 
    1355                 1360                 1365             


Asn Thr  Val Ser Pro Thr Gln  Asp Gly Thr Ser Ser  Leu Pro Arg 
    1370                 1375                 1380             


Arg Gln  Ser Ser Phe Ala Lys  Pro Pro Leu Arg Ala  Leu Tyr Asp 
    1385                 1390                 1395             


Leu Leu  Ile Ala Pro Met Glu  Gly Gly Leu Met His  Ser Ser Gly 
    1400                 1405                 1410             


Pro Val  Gly Arg His Arg Gln  Leu Ile Leu Val Leu  Glu Gly Glu 
    1415                 1420                 1425             


Leu Tyr  Leu Ile Pro Phe Ala  Leu Leu Lys Gly Ser  Ser Ser Asn 
    1430                 1435                 1440             


Glu Tyr  Leu Tyr Glu Arg Phe  Gly Leu Leu Ala Val  Pro Ser Ile 
    1445                 1450                 1455             


Arg Ser  Leu Ser Val Gln Ser  Lys Ser His Leu Arg  Lys Asn Pro 
    1460                 1465                 1470             


Pro Thr  Tyr Ser Ser Ser Thr  Ser Met Ala Ala Val  Ile Gly Asn 
    1475                 1480                 1485             


Pro Lys  Leu Pro Ser Ala Val  Met Asp Arg Trp Leu  Trp Gly Pro 
    1490                 1495                 1500             


Met Pro  Ser Ala Glu Glu Glu  Ala Tyr Met Val Ser  Glu Leu Leu 
    1505                 1510                 1515             


Gly Cys  Gln Pro Leu Val Gly  Ser Val Ala Thr Lys  Glu Arg Val 
    1520                 1525                 1530             


Met Ser  Ala Leu Thr Gln Ala  Glu Cys Val His Phe  Ala Thr His 
    1535                 1540                 1545             


Ile Ser  Trp Lys Leu Ser Ala  Leu Val Leu Thr Pro  Ser Met Asp 
    1550                 1555                 1560             


Gly Asn  Pro Ala Ser Ser Lys  Ser Ser Phe Gly His  Pro Tyr Thr 
    1565                 1570                 1575             


Ile Pro  Glu Ser Leu Arg Val  Gln Asp Asp Ala Ser  Asp Gly Glu 
    1580                 1585                 1590             


Ser Ile  Ser Asp Cys Pro Pro  Leu Gln Glu Leu Leu  Leu Thr Ala 
    1595                 1600                 1605             


Ala Asp  Val Leu Asp Leu Gln  Leu Pro Val Lys Leu  Val Val Leu 
    1610                 1615                 1620             


Gly Ser  Ser Gln Glu Ser Asn  Ser Lys Val Thr Ala  Asp Gly Val 
    1625                 1630                 1635             


Ile Ala  Leu Thr Arg Ala Phe  Leu Ala Ala Gly Ala  Gln Cys Val 
    1640                 1645                 1650             


Leu Val  Ser Leu Trp Pro Val  Pro Val Ala Ala Ser  Lys Met Phe 
    1655                 1660                 1665             


Ile His  Ala Phe Tyr Ser Ser  Leu Leu Asn Gly Leu  Lys Ala Ser 
    1670                 1675                 1680             


Ala Ala  Leu Gly Glu Ala Met  Lys Val Val Gln Ser  Ser Lys Ala 
    1685                 1690                 1695             


Phe Ser  His Pro Ser Asn Trp  Ala Gly Phe Met Leu  Ile Gly Ser 
    1700                 1705                 1710             


Asp Val  Lys Leu Asn Ser Pro  Ser Ser Leu Ile Gly  Gln Ala Leu 
    1715                 1720                 1725             


Thr Glu  Ile Leu Gln His Pro  Glu Arg Ala Arg Asp  Ala Leu Arg 
    1730                 1735                 1740             


Val Leu  Leu His Leu Val Glu  Lys Ser Leu Gln Arg  Ile Gln Asn 
    1745                 1750                 1755             


Gly Gln  Arg Asn Ala Met Tyr  Thr Ser Gln Gln Ser  Val Glu Asn 
    1760                 1765                 1770             


Lys Val  Gly Gly Ile Pro Gly  Trp Gln Ala Leu Leu  Thr Ala Val 
    1775                 1780                 1785             


Gly Phe  Arg Leu Asp Pro Pro  Thr Ser Gly Leu Pro  Ala Ala Val 
    1790                 1795                 1800             


Phe Phe  Pro Thr Ser Asp Pro  Gly Asp Arg Leu Gln  Gln Cys Ser 
    1805                 1810                 1815             


Ser Thr  Leu Gln Ser Leu Leu  Gly Leu Pro Asn Pro  Ala Leu Gln 
    1820                 1825                 1830             


Ala Leu  Cys Lys Leu Ile Thr  Ala Ser Glu Thr Gly  Glu Gln Leu 
    1835                 1840                 1845             


Ile Ser  Arg Ala Val Lys Asn  Met Val Gly Met Leu  His Gln Val 
    1850                 1855                 1860             


Leu Val  Gln Leu Gln Ala Gly  Glu Lys Glu Gln Asp  Leu Ala Ser 
    1865                 1870                 1875             


Ala Pro  Ile Gln Val Ser Ile  Ser Val Gln Leu Trp  Arg Leu Pro 
    1880                 1885                 1890             


Gly Cys  His Glu Phe Leu Ala  Ala Leu Gly Phe Asp  Leu Cys Glu 
    1895                 1900                 1905             


Val Gly  Gln Glu Glu Val Ile  Leu Lys Thr Gly Lys  Gln Ala Asn 
    1910                 1915                 1920             


Arg Arg  Thr Val His Phe Ala  Leu Gln Ser Leu Leu  Ser Leu Phe 
    1925                 1930                 1935             


Asp Ser  Thr Glu Leu Pro Lys  Arg Leu Ser Leu Asp  Ser Ser Ser 
    1940                 1945                 1950             


Ser Leu  Glu Ser Leu Ala Ser  Ala Gln Ser Val Ser  Asn Ala Leu 
    1955                 1960                 1965             


Pro Leu  Gly Tyr Gln Gln Pro  Pro Phe Ser Pro Thr  Gly Ala Asp 
    1970                 1975                 1980             


Ser Ile  Ala Ser Asp Ala Ile  Ser Val Tyr Ser Leu  Ser Ser Ile 
    1985                 1990                 1995             


Ala Ser  Ser Met Ser Phe Val  Ser Lys Pro Glu Gly  Gly Ser Glu 
    2000                 2005                 2010             


Gly Gly  Gly Pro Gly Gly Arg  Gln Asp His Asp Arg  Ser Lys Asn 
    2015                 2020                 2025             


Ala Tyr  Leu Gln Arg Ser Thr  Leu Pro Arg Ser Gln  Leu Pro Pro 
    2030                 2035                 2040             


Gln Thr  Arg Pro Ala Gly Asn  Lys Asp Glu Glu Glu  Tyr Glu Gly 
    2045                 2050                 2055             


Phe Ser  Ile Ile Ser Asn Glu  Pro Leu Ala Thr Tyr  Gln Glu Asn 
    2060                 2065                 2070             


Arg Asn  Thr Cys Phe Ser Pro  Asp His Lys Gln Pro  Gln Pro Gly 
    2075                 2080                 2085             


Thr Ala  Gly Gly Met Arg Val  Ser Val Ser Ser Lys  Gly Ser Ile 
    2090                 2095                 2100             


Ser Thr  Pro Asn Ser Pro Val  Lys Met Thr Leu Ile  Pro Ser Pro 
    2105                 2110                 2115             


Asn Ser  Pro Phe Gln Lys Val  Gly Lys Leu Ala Ser  Ser Asp Thr 
    2120                 2125                 2130             


Gly Glu  Ser Asp Gln Ser Ser  Thr Glu Thr Asp Ser  Thr Val Lys 
    2135                 2140                 2145             


Ser Gln  Glu Glu Ser Asn Pro  Lys Leu Asp Pro Gln  Glu Leu Ala 
    2150                 2155                 2160             


Gln Lys  Ile Leu Glu Glu Thr  Gln Ser His Leu Ile  Ala Val Glu 
    2165                 2170                 2175             


Arg Leu  Gln Arg Ser Gly Gly  Gln Val Ser Lys Ser  Asn Asn Pro 
    2180                 2185                 2190             


Glu Asp  Gly Val Gln Ala Pro  Ser Ser Thr Ala Val  Phe Arg Ala 
    2195                 2200                 2205             


Ser Glu  Thr Ser Ala Phe Ser  Arg Pro Val Leu Ser  His Gln Lys 
    2210                 2215                 2220             


Ser Gln  Pro Ser Pro Val Thr  Val Lys Pro Lys Pro  Pro Ala Arg 
    2225                 2230                 2235             


Ser Ser  Ser Leu Pro Lys Val  Ser Ser Gly Tyr Ser  Ser Pro Thr 
    2240                 2245                 2250             


Thr Ser  Glu Met Ser Ile Lys  Asp Ser Pro Ser Gln  His Ser Gly 
    2255                 2260                 2265             


Arg Pro  Ser Pro Gly Cys Asp  Ser Gln Thr Ser Gln  Leu Asp Gln 
    2270                 2275                 2280             


Pro Leu  Phe Lys Leu Lys Tyr  Pro Ser Ser Pro Tyr  Ser Ala His 
    2285                 2290                 2295             


Ile Ser  Lys Ser Pro Arg Asn  Met Ser Pro Ser Ser  Gly His Gln 
    2300                 2305                 2310             


Ser Pro  Ala Gly Ser Ala Pro  Ser Pro Ala Leu Ser  Tyr Ser Ser 
    2315                 2320                 2325             


Ala Gly  Ser Ala Arg Ser Ser  Pro Ala Asp Ala Pro  Asp Ile Asp 
    2330                 2335                 2340             


Lys Leu  Lys Met Ala Ala Ile  Asp Glu Lys Val Gln  Ala Val His 
    2345                 2350                 2355             


Asn Leu  Lys Met Phe Trp Gln  Ser Thr Pro Gln His  Ser Thr Gly 
    2360                 2365                 2370             


Pro Met  Lys Ile Phe Arg Gly  Ala Pro Gly Thr Met  Thr Ser Lys 
    2375                 2380                 2385             


Arg Asp  Val Leu Ser Leu Leu  Asn Leu Ser Pro Arg  His Asn Lys 
    2390                 2395                 2400             


Lys Glu  Glu Gly Val Asp Lys  Leu Glu Leu Lys Glu  Leu Ser Leu 
    2405                 2410                 2415             


Gln Gln  His Asp Gly Ala Pro  Pro Lys Ala Pro Pro  Asn Gly His 
    2420                 2425                 2430             


Trp Arg  Thr Glu Thr Thr Ser  Leu Gly Ser Leu Pro  Leu Pro Ala 
    2435                 2440                 2445             


Gly Pro  Pro Ala Thr Ala Pro  Ala Arg Pro Leu Arg  Leu Pro Ser 
    2450                 2455                 2460             


Gly Asn  Gly Tyr Lys Phe Leu  Ser Pro Gly Arg Phe  Phe Pro Ser 
    2465                 2470                 2475             


Ser Lys  Cys 
    2480     


<210>  1857
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  1857

Met Ser Arg Asn Leu Arg Thr Ala Leu Ile Phe Gly Gly Phe Ile Ser 
1               5                   10                  15      


Leu Ile Gly Ala Ala Phe Tyr Pro Ile Tyr Phe Arg Pro Leu Met Arg 
            20                  25                  30          


Leu Glu Glu Tyr Lys Lys Glu Gln Ala Ile Asn Arg Ala Gly Ile Val 
        35                  40                  45              


Gln Glu Asp Val Gln Pro Pro Gly Leu Lys Val Trp Ser Asp Pro Phe 
    50                  55                  60                  


Gly Arg Lys 
65          


<210>  1858
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  1858

Met Ala Arg Leu Gly Ser Thr Gly Gly Val Ser Gly Arg Val Val Thr 
1               5                   10                  15      


Gln His Arg Asp Ser Ala Pro Phe Leu Gly Ala Pro Arg Leu Gly Leu 
            20                  25                  30          


Arg Glu Leu Gly Pro Ile Arg Gly Thr Ala Pro Glu Trp His Gly Arg 
        35                  40                  45              


Trp Asn Ala Ala Glu Arg Ser Asp Lys Met Tyr Gln Val Pro Leu Pro 
    50                  55                  60                  


Leu Asp Arg Asp Gly Thr Leu Val Arg Leu Arg Phe Thr Met Val Ala 
65                  70                  75                  80  


Leu Val Thr Val Cys Cys Pro Leu Val Ala Phe Leu Phe Cys Ile Leu 
                85                  90                  95      


Trp Ser Leu Leu Phe His Phe Lys Glu Thr Thr Ala Thr His Cys Gly 
            100                 105                 110         


Val Pro Asn Tyr Leu Pro Ser Val Ser Ser Ala Ile Gly Gly Glu Val 
        115                 120                 125             


Pro Gln Arg Tyr Val Trp Arg Phe Cys Ile Gly Leu His Ser Ala Pro 
    130                 135                 140                 


Arg Phe Leu Val Ala Phe Ala Tyr Trp Asn His Tyr Leu Ser Cys Thr 
145                 150                 155                 160 


Ser Pro Cys Ser Cys Tyr Arg Pro Leu Cys Arg Leu Asn Phe Gly Leu 
                165                 170                 175     


Asn Val Val Glu Asn Leu Ala Leu Leu Val Leu Thr Tyr Val Ser Ser 
            180                 185                 190         


Ser Glu Asp Phe Thr Ile His Glu Asn Ala Phe Ile Val Phe Ile Ala 
        195                 200                 205             


Ser Ser Leu Gly His Met Leu Leu Thr Cys Ile Leu Trp Arg Leu Thr 
    210                 215                 220                 


Lys Lys His Thr Asp Arg Lys Ser Tyr Ser Trp Lys Gln Arg Leu Phe 
225                 230                 235                 240 


Ile Ile Asn Phe Ile Ser Phe Phe Ser Ala Leu Ala Val Tyr Phe Arg 
                245                 250                 255     


His Asn Met Tyr Cys Glu Ala Gly Val Tyr Thr Ile Phe Ala Ile Leu 
            260                 265                 270         


Glu Tyr Thr Val Val Leu Thr Asn Met Ala Phe His Met Thr Ala Trp 
        275                 280                 285             


Trp Asp Phe Gly Asn Lys Glu Leu Leu Ile Thr Ser Gln Pro Glu Glu 
    290                 295                 300                 


Lys Arg Phe 
305         


<210>  1859
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  1859

Met Ala Arg Leu Gly Ser Thr Gly Gly Val Ser Gly Arg Val Val Thr 
1               5                   10                  15      


Gln His Arg Asp Ser Ala Pro Phe Leu Gly Ala Pro Arg Leu Gly Leu 
            20                  25                  30          


Arg Glu Leu Gly Pro Ile Arg Gly Thr Ala Pro Glu Trp His Gly Arg 
        35                  40                  45              


Trp Asn Ala Ala Glu Arg Ser Asp Lys Met Tyr Gln Val Pro Leu Pro 
    50                  55                  60                  


Leu Asp Arg Asp Gly Thr Leu Val Arg Leu Arg Phe Thr Met Val Ala 
65                  70                  75                  80  


Leu Val Thr Val Cys Cys Pro Leu Val Ala Phe Leu Phe Cys Ile Leu 
                85                  90                  95      


Trp Ser Leu Leu Phe His Phe Lys Glu Thr Thr Ala Thr His Cys Gly 
            100                 105                 110         


Val Pro Asn Tyr Leu Pro Ser Val Ser Ser Ala Ile Gly Gly Glu Val 
        115                 120                 125             


Pro Gln Arg Tyr Val Trp Arg Phe Cys Ile Gly Leu His Ser Ala Pro 
    130                 135                 140                 


Arg Phe Leu Val Ala Phe Ala Tyr Trp Asn His Tyr Leu Ser Cys Thr 
145                 150                 155                 160 


Ser Pro Cys Ser Cys Tyr Arg Pro Leu Cys Arg Leu Asn Phe Gly Leu 
                165                 170                 175     


Asn Val Val Glu Asn Leu Ala Leu Leu Val Leu Thr Tyr Val Ser Ser 
            180                 185                 190         


Ser Glu Asp Phe Thr Ile His Glu Asn Ala Phe Ile Val Phe Ile Ala 
        195                 200                 205             


Ser Ser Leu Gly His Met Leu Leu Thr Cys Ile Leu Trp Arg Leu Thr 
    210                 215                 220                 


Lys Lys His Thr Asp Arg Lys Ser Tyr Ser Trp Lys Gln Arg Leu Phe 
225                 230                 235                 240 


Ile Ile Asn Phe Ile Ser Phe Phe Ser Ala Leu Ala Val Tyr Phe Arg 
                245                 250                 255     


His Asn Met Tyr Cys Glu Ala Gly Val Tyr Thr Ile Phe Ala Ile Leu 
            260                 265                 270         


Glu Tyr Thr Val Val Leu Thr Asn Met Ala Phe His Met Thr Ala Trp 
        275                 280                 285             


Trp Asp Phe Gly Asn Lys Glu Leu Leu Ile Thr Ser Gln Pro Glu Glu 
    290                 295                 300                 


Lys Arg Phe 
305         


<210>  1860
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  1860

Met Ser Ser Thr Leu Pro Ala Leu Leu Cys Val Gly Leu Cys Leu Ser 
1               5                   10                  15      


Gln Arg Ile Ser Ala Gln Gln Gln Thr Leu Pro Lys Pro Phe Ile Trp 
            20                  25                  30          


Ala Glu Pro His Phe Met Val Pro Lys Glu Lys Gln Val Thr Ile Cys 
        35                  40                  45              


Cys Gln Gly Asn Tyr Gly Ala Val Glu Tyr Gln Leu His Phe Glu Gly 
    50                  55                  60                  


Ser Leu Phe Ala Val Asp Arg Pro Lys Pro Pro Glu Arg Ile Asn Lys 
65                  70                  75                  80  


Val Gln Phe Tyr Ile Pro Asp Met Asn Ser Arg Met Ala Gly Gln Tyr 
                85                  90                  95      


Ser Cys Ile Tyr Arg Val Gly Glu Leu Trp Ser Glu Pro Ser Asn Leu 
            100                 105                 110         


Leu Asp Leu Val Val Thr Glu Met Tyr Asp Thr Pro Thr Leu Ser Val 
        115                 120                 125             


His Pro Gly Pro Glu Val Ile Ser Gly Glu Lys Val Thr Phe Tyr Cys 
    130                 135                 140                 


Arg Leu Asp Thr Ala Thr Ser Met Phe Leu Leu Leu Lys Glu Gly Arg 
145                 150                 155                 160 


Ser Ser His Val Gln Arg Gly Tyr Gly Lys Val Gln Ala Glu Phe Pro 
                165                 170                 175     


Leu Gly Pro Val Thr Thr Ala His Arg Gly Thr Tyr Arg Cys Phe Gly 
            180                 185                 190         


Ser Tyr Asn Asn His Ala Trp Ser Phe Pro Ser Glu Pro Val Lys Leu 
        195                 200                 205             


Leu Val Thr Gly Asp Ile Glu Asn Thr Ser Leu Ala Pro Glu Asp Pro 
    210                 215                 220                 


Thr Phe Pro Asp Thr Trp Gly Thr Tyr Leu Leu Thr Thr Glu Thr Gly 
225                 230                 235                 240 


Leu Gln Lys Asp His Ala Leu Trp Asp His Thr Ala Gln Asn Leu Leu 
                245                 250                 255     


Arg Met Gly Leu Ala Phe Leu Val Leu Val Ala Leu Val Trp Phe Leu 
            260                 265                 270         


Val Glu Asp Trp Leu Ser Arg Lys Arg Thr Arg Glu Arg Ala Ser Arg 
        275                 280                 285             


Ala Ser Thr Trp Glu Gly Arg Arg Arg Leu Asn Thr Gln Thr Leu 
    290                 295                 300             


<210>  1861
<211>  287
<212>  PRT
<213>  Homo sapiens

<400>  1861

Met Ser Ser Thr Leu Pro Ala Leu Leu Cys Val Gly Leu Cys Leu Ser 
1               5                   10                  15      


Gln Arg Ile Ser Ala Gln Gln Gln Thr Leu Pro Lys Pro Phe Ile Trp 
            20                  25                  30          


Ala Glu Pro His Phe Met Val Pro Lys Glu Lys Gln Val Thr Ile Cys 
        35                  40                  45              


Cys Gln Gly Asn Tyr Gly Ala Val Glu Tyr Gln Leu His Phe Glu Gly 
    50                  55                  60                  


Ser Leu Phe Ala Val Asp Arg Pro Lys Pro Pro Glu Arg Ile Asn Lys 
65                  70                  75                  80  


Val Gln Phe Tyr Ile Pro Asp Met Asn Ser Arg Met Ala Gly Gln Tyr 
                85                  90                  95      


Ser Cys Ile Tyr Arg Val Gly Glu Leu Trp Ser Glu Pro Ser Asn Leu 
            100                 105                 110         


Leu Asp Leu Val Val Thr Glu Met Tyr Asp Thr Pro Thr Leu Ser Val 
        115                 120                 125             


His Pro Gly Pro Glu Val Ile Ser Gly Glu Lys Val Thr Phe Tyr Cys 
    130                 135                 140                 


Arg Leu Asp Thr Ala Thr Ser Met Phe Leu Leu Leu Lys Glu Gly Arg 
145                 150                 155                 160 


Ser Ser His Val Gln Arg Gly Tyr Gly Lys Val Gln Ala Glu Phe Pro 
                165                 170                 175     


Leu Gly Pro Val Thr Thr Ala His Arg Gly Thr Tyr Arg Cys Phe Gly 
            180                 185                 190         


Ser Tyr Asn Asn His Ala Trp Ser Phe Pro Ser Glu Pro Val Lys Leu 
        195                 200                 205             


Leu Val Thr Gly Asp Ile Glu Asn Thr Ser Leu Ala Pro Glu Asp Pro 
    210                 215                 220                 


Thr Phe Pro Asp His Ala Leu Trp Asp His Thr Ala Gln Asn Leu Leu 
225                 230                 235                 240 


Arg Met Gly Leu Ala Phe Leu Val Leu Val Ala Leu Val Trp Phe Leu 
                245                 250                 255     


Val Glu Asp Trp Leu Ser Arg Lys Arg Thr Arg Glu Arg Ala Ser Arg 
            260                 265                 270         


Ala Ser Thr Trp Glu Gly Arg Arg Arg Leu Asn Thr Gln Thr Leu 
        275                 280                 285         


<210>  1862
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  1862

Met Pro Ala Ser Lys Arg Arg Ile Pro Val Ser Gln Pro Gly Met Ala 
1               5                   10                  15      


Asp Pro His Gln Leu Phe Asp Asp Thr Ser Ser Ala Gln Ser Arg Gly 
            20                  25                  30          


Tyr Gly Ala Gln Arg Ala Pro Gly Gly Leu Ser Tyr Pro Ala Ala Ser 
        35                  40                  45              


Pro Thr Pro His Ala Ala Phe Leu Ala Asp Pro Val Ser Asn Met Ala 
    50                  55                  60                  


Met Ala Tyr Gly Ser Ser Leu Ala Ala Gln Gly Lys Glu Leu Val Asp 
65                  70                  75                  80  


Lys Asn Ile Asp Arg Phe Ile Pro Ile Thr Lys Leu Lys Tyr Tyr Phe 
                85                  90                  95      


Ala Val Asp Thr Met Tyr Val Gly Arg Lys Leu Gly Leu Leu Phe Phe 
            100                 105                 110         


Pro Tyr Leu His Gln Asp Trp Glu Val Gln Tyr Gln Gln Asp Thr Pro 
        115                 120                 125             


Val Ala Pro Arg Phe Asp Val Asn Ala Pro Asp Leu Tyr Ile Pro Ala 
    130                 135                 140                 


Met Ala Phe Ile Thr Tyr Val Leu Val Ala Gly Leu Ala Leu Gly Thr 
145                 150                 155                 160 


Gln Asp Arg Phe Ser Pro Asp Leu Leu Gly Leu Gln Ala Ser Ser Ala 
                165                 170                 175     


Leu Ala Trp Leu Thr Leu Glu Val Leu Ala Ile Leu Leu Ser Leu Tyr 
            180                 185                 190         


Leu Val Thr Val Asn Thr Asp Leu Thr Thr Ile Asp Leu Val Ala Phe 
        195                 200                 205             


Leu Gly Tyr Lys Tyr Val Gly Met Ile Gly Gly Val Leu Met Gly Leu 
    210                 215                 220                 


Leu Phe Gly Lys Ile Gly Tyr Tyr Leu Val Leu Gly Trp Cys Cys Val 
225                 230                 235                 240 


Ala Ile Phe Val Phe Met Ile Arg Thr Leu Arg Leu Lys Ile Leu Ala 
                245                 250                 255     


Asp Ala Ala Ala Glu Gly Val Pro Val Arg Gly Ala Arg Asn Gln Leu 
            260                 265                 270         


Arg Met Tyr Leu Thr Met Ala Val Ala Ala Ala Gln Pro Met Leu Met 
        275                 280                 285             


Tyr Trp Leu Thr Phe His Leu Val Arg 
    290                 295         


<210>  1863
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  1863

Met Ala Asp Pro His Gln Leu Phe Asp Asp Thr Ser Ser Ala Gln Ser 
1               5                   10                  15      


Arg Gly Tyr Gly Ala Gln Arg Ala Pro Gly Gly Leu Ser Tyr Pro Ala 
            20                  25                  30          


Ala Ser Pro Thr Pro His Ala Ala Phe Leu Ala Asp Pro Val Ser Asn 
        35                  40                  45              


Met Ala Met Ala Tyr Gly Ser Ser Leu Ala Ala Gln Gly Lys Glu Leu 
    50                  55                  60                  


Val Asp Lys Asn Ile Asp Arg Phe Ile Pro Ile Thr Lys Leu Lys Tyr 
65                  70                  75                  80  


Tyr Phe Ala Val Asp Thr Met Tyr Val Gly Arg Lys Leu Gly Leu Leu 
                85                  90                  95      


Phe Phe Pro Tyr Leu His Gln Asp Trp Glu Val Gln Tyr Gln Gln Asp 
            100                 105                 110         


Thr Pro Val Ala Pro Arg Phe Asp Val Asn Ala Pro Asp Leu Tyr Ile 
        115                 120                 125             


Pro Ala Met Ala Phe Ile Thr Tyr Val Leu Val Ala Gly Leu Ala Leu 
    130                 135                 140                 


Gly Thr Gln Asp Arg Phe Ser Pro Asp Leu Leu Gly Leu Gln Ala Ser 
145                 150                 155                 160 


Ser Ala Leu Ala Trp Leu Thr Leu Glu Val Leu Ala Ile Leu Leu Ser 
                165                 170                 175     


Leu Tyr Leu Val Thr Val Asn Thr Asp Leu Thr Thr Ile Asp Leu Val 
            180                 185                 190         


Ala Phe Leu Gly Tyr Lys Tyr Val Gly Met Ile Gly Gly Val Leu Met 
        195                 200                 205             


Gly Leu Leu Phe Gly Lys Ile Gly Tyr Tyr Leu Val Leu Gly Trp Cys 
    210                 215                 220                 


Cys Val Ala Ile Phe Val Phe Met Ile Arg Thr Leu Arg Leu Lys Ile 
225                 230                 235                 240 


Leu Ala Asp Ala Ala Ala Glu Gly Val Pro Val Arg Gly Ala Arg Asn 
                245                 250                 255     


Gln Leu Arg Met Tyr Leu Thr Met Ala Val Ala Ala Ala Gln Pro Met 
            260                 265                 270         


Leu Met Tyr Trp Leu Thr Phe His Leu Val Arg 
        275                 280             


<210>  1864
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  1864

Met His Pro Ala Gly Leu Ala Ala Ala Ala Ala Gly Thr Pro Arg Leu 
1               5                   10                  15      


Pro Ser Lys Arg Arg Ile Pro Val Ser Gln Pro Gly Met Ala Asp Pro 
            20                  25                  30          


His Gln Leu Phe Asp Asp Thr Ser Ser Ala Gln Ser Arg Gly Tyr Gly 
        35                  40                  45              


Ala Gln Arg Ala Pro Gly Gly Leu Ser Tyr Pro Ala Ala Ser Pro Thr 
    50                  55                  60                  


Pro His Ala Ala Phe Leu Ala Asp Pro Val Ser Asn Met Ala Met Ala 
65                  70                  75                  80  


Tyr Gly Ser Ser Leu Ala Ala Gln Gly Lys Glu Leu Val Asp Lys Asn 
                85                  90                  95      


Ile Asp Arg Phe Ile Pro Ile Thr Lys Leu Lys Tyr Tyr Phe Ala Val 
            100                 105                 110         


Asp Thr Met Tyr Val Gly Arg Lys Leu Gly Leu Leu Phe Phe Pro Tyr 
        115                 120                 125             


Leu His Gln Asp Trp Glu Val Gln Tyr Gln Gln Asp Thr Pro Val Ala 
    130                 135                 140                 


Pro Arg Phe Asp Val Asn Ala Pro Asp Leu Tyr Ile Pro Ala Met Ala 
145                 150                 155                 160 


Phe Ile Thr Tyr Val Leu Val Ala Gly Leu Ala Leu Gly Thr Gln Asp 
                165                 170                 175     


Arg Phe Ser Pro Asp Leu Leu Gly Leu Gln Ala Ser Ser Ala Leu Ala 
            180                 185                 190         


Trp Leu Thr Leu Glu Val Leu Ala Ile Leu Leu Ser Leu Tyr Leu Val 
        195                 200                 205             


Thr Val Asn Thr Asp Leu Thr Thr Ile Asp Leu Val Ala Phe Leu Gly 
    210                 215                 220                 


Tyr Lys Tyr Val Gly Met Ile Gly Gly Val Leu Met Gly Leu Leu Phe 
225                 230                 235                 240 


Gly Lys Ile Gly Tyr Tyr Leu Val Leu Gly Trp Cys Cys Val Ala Ile 
                245                 250                 255     


Phe Val Phe Met Phe Pro Leu Leu Pro Gly Ala Val Ala His Ala Cys 
            260                 265                 270         


Asn Pro Ser Thr Leu Gly Gly Arg Gly Gly Arg Ile Thr Arg Ser Gly 
        275                 280                 285             


Arg Cys Gly 
    290     


<210>  1865
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  1865

Met Ala Ile Lys Ser Ile Ala Ser Arg Leu Arg Gly Ser Arg Arg Phe 
1               5                   10                  15      


Leu Ser Gly Phe Val Ala Gly Ala Val Val Gly Ala Ala Gly Ala Gly 
            20                  25                  30          


Leu Ala Ala Leu Gln Phe Phe Arg Ser Gln Gly Ala Glu Gly Ala Leu 
        35                  40                  45              


Thr Gly Lys Gln Pro Asp Gly Asp Ala Asp Arg Lys His Cys Lys Phe 
    50                  55                  60                  


Lys Pro Asp Pro Asn Ile Pro Pro Thr Phe Ser Ala Phe Asn Glu Asp 
65                  70                  75                  80  


Tyr Val Gly Ser Gly Trp Ser Arg Gly His Met Ala Pro Ala Gly Asn 
                85                  90                  95      


Asn Lys Phe Ser Ser Lys Ala Met Ala Glu Thr Phe Tyr Leu Ser Asn 
            100                 105                 110         


Ile Val Pro Gln Asp Phe Asp Asn Asn Ser Gly Tyr Trp Asn Arg Ile 
        115                 120                 125             


Glu Met Tyr Cys Arg Glu Leu Thr Glu Arg Phe Glu Asp Val Trp Val 
    130                 135                 140                 


Val Ser Gly Pro Leu Thr Leu Pro Gln Thr Arg Gly Asp Gly Lys Lys 
145                 150                 155                 160 


Ile Val Ser Tyr Gln Val Ile Gly Glu Asp Asn Val Ala Val Pro Ser 
                165                 170                 175     


His Leu Tyr Lys Val Ile Leu Ala Arg Arg Ser Ser Val Ser Thr Glu 
            180                 185                 190         


Pro Leu Ala Leu Gly Ala Phe Val Val Pro Asn Glu Ala Ile Gly Phe 
        195                 200                 205             


Gln Pro Gln Leu Thr Glu Phe Gln Val Ser Leu Gln Asp Leu Glu Lys 
    210                 215                 220                 


Leu Ser Gly Leu Val Phe Phe Pro His Leu Asp Arg Thr Ser Asp Ile 
225                 230                 235                 240 


Arg Asn Ile Cys Ser Val Asp Thr Cys Lys Leu Leu Asp Phe Gln Glu 
                245                 250                 255     


Phe Thr Leu Tyr Leu Ser Thr Arg Lys Ile Glu Gly Ala Arg Ser Val 
            260                 265                 270         


Leu Arg Leu Glu Lys Ile Met Glu Asn Leu Lys Asn Ala Glu Ile Glu 
        275                 280                 285             


Pro Asp Asp Tyr Phe Met Ser Arg Tyr Glu Lys Lys Leu Glu Glu Leu 
    290                 295                 300                 


Lys Ala Lys Glu Gln Ser Gly Thr Gln Ile Arg Lys Pro Ser 
305                 310                 315             


<210>  1866
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  1866

Met Ala Trp Met Leu Leu Leu Ile Leu Ile Met Val His Pro Gly Ser 
1               5                   10                  15      


Cys Ala Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly 
            20                  25                  30          


Ser Ser Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu 
        35                  40                  45              


Ala Ile Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys 
    50                  55                  60                  


Glu Val Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu 
65                  70                  75                  80  


Ala Ser Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg 
                85                  90                  95      


Asp Val Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val 
            100                 105                 110         


Leu Gly Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu 
        115                 120                 125             


Lys Glu His Pro Gln Leu Gly Ala Gly Thr Val Leu Leu Leu Arg Ala 
    130                 135                 140                 


Gly Phe Tyr Ala Val Ser Phe Leu Ser Val Ala Val Gly Ser Thr Val 
145                 150                 155                 160 


Tyr Tyr Gln Gly Lys Tyr Ala Lys Ser Thr Leu Ser Gly Phe Pro Gln 
                165                 170                 175     


Leu 
    


<210>  1867
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  1867

Met Ala Trp Met Leu Leu Leu Ile Leu Ile Met Val His Pro Gly Ser 
1               5                   10                  15      


Cys Ala Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly 
            20                  25                  30          


Ser Ser Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu 
        35                  40                  45              


Ala Ile Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys 
    50                  55                  60                  


Glu Val Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu 
65                  70                  75                  80  


Ala Ser Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg 
                85                  90                  95      


Asp Val Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val 
            100                 105                 110         


Leu Gly Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu 
        115                 120                 125             


Lys Glu His Pro Gln Leu Gly Ala Gly Thr Val Leu Leu Leu Arg Ala 
    130                 135                 140                 


Gly Phe Tyr Ala Val Ser Phe Leu Ser Val Ala Val Gly Ser Thr Val 
145                 150                 155                 160 


Tyr Tyr Gln Gly Lys Cys His Cys His Met Gly Thr His Cys His Ser 
                165                 170                 175     


Ser Asp Gly Pro Arg Gly Val Ile Pro Glu Pro Arg Cys Pro 
            180                 185                 190 


<210>  1868
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  1868

Met Asp Ser Gln Gln Glu Asp Leu Arg Phe Pro Gly Met Trp Val Ser 
1               5                   10                  15      


Leu Tyr Phe Gly Ile Leu Gly Leu Cys Ser Val Ile Thr Gly Gly Cys 
            20                  25                  30          


Ile Ile Phe Leu His Trp Arg Lys Asn Leu Arg Arg Glu Glu His Ala 
        35                  40                  45              


Gln Gln Trp Val Glu Val Met Arg Ala Ala Thr Phe Thr Tyr Ser Pro 
    50                  55                  60                  


Leu Leu Tyr Trp Ile Asn Lys Arg Arg Arg Tyr Gly Met Asn Ala Ala 
65                  70                  75                  80  


Ile Asn Thr Gly Pro Ala Pro Ala Val Thr Lys Thr Glu Thr Glu Val 
                85                  90                  95      


Gln Asn Pro Asp Val Leu Trp Asp Leu Asp Ile Pro Glu Gly Arg Ser 
            100                 105                 110         


His Ala Asp Gln Asp Ser Asn Pro Lys Ala Glu Ala Pro Ala Pro Leu 
        115                 120                 125             


Gln Pro Ala Leu Gln Leu Ala Pro Gln Gln Pro Gln Ala Arg Ser Pro 
    130                 135                 140                 


Phe Pro Leu Pro Ile Phe Gln Glu Val Pro Phe Ala Pro Pro Leu Cys 
145                 150                 155                 160 


Asn Leu Pro Pro Leu Leu Asn His Ser Val Ser Tyr Pro Leu Ala Thr 
                165                 170                 175     


Cys Pro Glu Arg Asn Val Leu Phe His Ser Leu Leu Asn Leu Ala Gln 
            180                 185                 190         


Glu Asp His Ser Phe Asn Ala Lys Pro Phe Pro Ser Glu Leu 
        195                 200                 205     


<210>  1869
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  1869

Met Ala Arg Leu Gly Ala Leu Leu Leu Ala Ala Ala Leu Gly Ala Leu 
1               5                   10                  15      


Leu Ser Phe Ala Leu Leu Ala Ala Ala Val Ala Ser Asp Tyr Trp Tyr 
            20                  25                  30          


Ile Leu Glu Val Ala Asp Ala Gly Asn Gly Ser Ala Trp Pro Gly Arg 
        35                  40                  45              


Ala Glu Leu Leu Ser Ser His Ser Gly Leu Trp Arg Ile Cys Glu Gly 
    50                  55                  60                  


Gln Asn Gly Cys Ile Pro Leu Val Asp Pro Phe Ala Ser Glu Ser Leu 
65                  70                  75                  80  


Asp Val Ser Thr Ser Val Gln His Leu Ile Leu Leu His Arg Ala Val 
                85                  90                  95      


Ile Val Val Leu Pro Leu Ser Leu Val Leu Leu Val Cys Gly Trp Ile 
            100                 105                 110         


Cys Gly Leu Leu Ser Ser Leu Ala Gln Ser Val Ser Leu Leu Leu Phe 
        115                 120                 125             


Thr Gly Cys Tyr Phe Leu Leu Gly Ser Val Leu Thr Leu Ala Gly Val 
    130                 135                 140                 


Ser Ile Tyr Ile Ser Tyr Ser His Leu Ala Phe Ala Glu Thr Val Gln 
145                 150                 155                 160 


Gln Tyr Gly Pro Gln His Met Gln Gly Val Arg Val Ser Phe Gly Trp 
                165                 170                 175     


Ser Met Ala Leu Ala Trp Gly Ser Cys Ala Leu Glu Ala Phe Ser Gly 
            180                 185                 190         


Thr Leu Leu Leu Ser Ala Ala Trp Thr Leu Ser Leu Ser Pro Pro Ile 
        195                 200                 205             


Cys Gly His Leu Ser Pro Gln Gln Val Gly Gly Arg Gly Gly Asp 
    210                 215                 220             


<210>  1870
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  1870

Met Gln Pro Ser Gly His Arg Leu Arg Asp Val Glu His His Pro Leu 
1               5                   10                  15      


Leu Ala Glu Asn Asp Asn Tyr Asp Ser Ser Ser Ser Ser Ser Ser Glu 
            20                  25                  30          


Ala Asp Val Ala Asp Arg Val Trp Phe Ile Arg Asp Gly Cys Gly Met 
        35                  40                  45              


Ile Cys Ala Val Met Thr Trp Leu Leu Val Ala Tyr Ala Asp Phe Val 
    50                  55                  60                  


Val Thr Phe Val Met Leu Leu Pro Ser Lys Asp Phe Trp Tyr Ser Val 
65                  70                  75                  80  


Val Asn Gly Val Ile Phe Asn Cys Leu Ala Val Leu Ala Leu Ser Ser 
                85                  90                  95      


His Leu Arg Thr Met Leu Thr Asp Pro Glu Lys Ser Ser Asp Cys Arg 
            100                 105                 110         


Pro Ser Ala Cys Thr Val Lys Thr Gly Leu Asp Pro Thr Leu Val Gly 
        115                 120                 125             


Ile Cys Gly Glu Gly Thr Glu Ser Val Gln Ser Leu Leu Leu Gly Ala 
    130                 135                 140                 


Val Pro Lys Gly Asn Ala Thr Lys Glu Tyr Met Glu Ser Leu Gln Leu 
145                 150                 155                 160 


Lys Pro Gly Glu Val Ile Tyr Lys Cys Pro Lys Cys Cys Cys Ile Lys 
                165                 170                 175     


Pro Glu Arg Ala His His Cys Ser Ile Cys Lys Arg Cys Ile Arg Lys 
            180                 185                 190         


Met Asp His His Cys Pro Trp Val Asn Asn Cys Val Gly Glu Lys Asn 
        195                 200                 205             


Gln Arg Phe Phe Val Leu Phe Thr Met Tyr Ile Ala Leu Ser Ser Val 
    210                 215                 220                 


His Ala Leu Ile Leu Cys Gly Phe Gln Phe Ile Ser Cys Val Arg Gly 
225                 230                 235                 240 


Gln Trp Thr Glu Cys Ser Asp Phe Ser Pro Pro Ile Thr Val Ile Leu 
                245                 250                 255     


Leu Ile Phe Leu Cys Leu Glu Gly Leu Leu Phe Phe Thr Phe Thr Ala 
            260                 265                 270         


Val Met Phe Gly Thr Gln Ile His Ser Ile Cys Asn Asp Glu Thr Glu 
        275                 280                 285             


Ile Glu Arg Leu Lys Ser Glu Lys Pro Thr Trp Glu Arg Arg Leu Arg 
    290                 295                 300                 


Trp Glu Gly Met Lys Ser Val Phe Gly Gly Pro Pro Ser Leu Leu Trp 
305                 310                 315                 320 


Met Asn Pro Phe Val Gly Phe Arg Phe Arg Arg Leu Pro Thr Arg Pro 
                325                 330                 335     


Arg Lys Gly Gly Pro Glu Phe Ser Val 
            340                 345 


<210>  1871
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  1871

Met Asp Asp Ser Thr Glu Arg Glu Gln Ser Arg Leu Thr Ser Cys Leu 
1               5                   10                  15      


Lys Lys Arg Glu Glu Met Lys Leu Lys Glu Cys Val Ser Ile Leu Pro 
            20                  25                  30          


Arg Lys Glu Ser Pro Ser Val Arg Ser Ser Lys Asp Gly Lys Leu Leu 
        35                  40                  45              


Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Cys Cys Leu Thr Val Val 
    50                  55                  60                  


Ser Phe Tyr Gln Val Ala Ala Leu Gln Gly Asp Leu Ala Ser Leu Arg 
65                  70                  75                  80  


Ala Glu Leu Gln Gly His His Ala Glu Lys Leu Pro Ala Gly Ala Gly 
                85                  90                  95      


Ala Pro Lys Ala Gly Leu Glu Glu Ala Pro Ala Val Thr Ala Gly Leu 
            100                 105                 110         


Lys Ile Phe Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Asn 
        115                 120                 125             


Ser Arg Asn Lys Arg Ala Val Gln Gly Pro Glu Glu Thr Gly Ser Tyr 
    130                 135                 140                 


Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser Ala Leu Glu 
145                 150                 155                 160 


Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr Phe Phe Ile 
                165                 170                 175     


Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met Gly His Leu 
            180                 185                 190         


Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser Leu Val 
        195                 200                 205             


Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu Pro Asn Asn 
    210                 215                 220                 


Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu Leu 
225                 230                 235                 240 


Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu Asp Gly Asp 
                245                 250                 255     


Val Thr Phe Phe Gly Ala Leu Lys Leu Leu 
            260                 265     


<210>  1872
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  1872

Met Thr Ala Ala Val Phe Phe Gly Cys Ala Phe Ile Ala Phe Gly Pro 
1               5                   10                  15      


Ala Leu Ala Leu Tyr Val Phe Thr Ile Ala Thr Glu Pro Leu Arg Ile 
            20                  25                  30          


Ile Phe Leu Ile Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Ile 
        35                  40                  45              


Ser Ser Leu Val Trp Phe Met Ala Arg Val Ile Ile Asp Asn Lys Asp 
    50                  55                  60                  


Gly Pro Thr Gln Lys Tyr Leu Leu Ile Phe Gly Ala Phe Val Ser Val 
65                  70                  75                  80  


Tyr Ile Gln Glu Met Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Ser Glu Gly Leu Lys Ser Ile Asn Pro Gly Glu Thr Ala Pro Ser 
            100                 105                 110         


Met Arg Leu Leu Ala Tyr Ala Phe Met Thr Leu Val Ile Ile Leu Leu 
        115                 120                 125             


His Val Phe Trp Gly Ile Val Phe Phe Asp Gly Cys Glu Lys Lys Lys 
    130                 135                 140                 


Trp Gly Ile Leu Leu Ile Val Leu Leu Thr His Leu Leu Val Ser Ala 
145                 150                 155                 160 


Gln Thr Phe Ile Ser Ser Tyr Tyr Gly Ile Asn Leu Ala Ser Ala Phe 
                165                 170                 175     


Ile Ile Leu Val Leu Met Gly Thr Trp Ala Phe Leu Ala Ala Gly Gly 
            180                 185                 190         


Ser Cys Arg Ser Leu Lys Leu Cys Leu Leu Cys Gln Asp Lys Asn Phe 
        195                 200                 205             


Leu Leu Tyr Asn Gln Arg Ser Arg 
    210                 215     


<210>  1873
<211>  777
<212>  PRT
<213>  Homo sapiens

<400>  1873

Met Glu Glu Pro Gly Ala Thr Pro Gln Pro Tyr Leu Gly Leu Val Leu 
1               5                   10                  15      


Glu Glu Leu Gly Arg Val Val Ala Ala Leu Pro Glu Ser Met Arg Pro 
            20                  25                  30          


Asp Glu Asn Pro Tyr Gly Phe Pro Ser Glu Leu Val Val Cys Ala Ala 
        35                  40                  45              


Val Ile Gly Phe Phe Val Val Leu Leu Phe Leu Trp Arg Ser Phe Arg 
    50                  55                  60                  


Ser Val Arg Ser Arg Leu Tyr Val Gly Arg Glu Gln Lys Leu Gly Ala 
65                  70                  75                  80  


Thr Leu Ser Gly Leu Ile Glu Glu Lys Cys Lys Leu Leu Glu Lys Phe 
                85                  90                  95      


Ser Leu Ile Gln Lys Glu Tyr Glu Gly Tyr Glu Val Glu Ser Ser Leu 
            100                 105                 110         


Glu Asp Ala Ser Phe Glu Lys Ala Ala Ala Glu Glu Ala Arg Ser Leu 
        115                 120                 125             


Glu Ala Thr Cys Glu Lys Leu Ser Arg Ser Asn Ser Glu Leu Glu Asp 
    130                 135                 140                 


Glu Ile Leu Cys Leu Glu Lys Asp Leu Lys Glu Glu Lys Ser Lys His 
145                 150                 155                 160 


Ser Gln Gln Asp Glu Leu Met Ala Asp Ile Ser Lys Ser Ile Gln Ser 
                165                 170                 175     


Leu Glu Asp Glu Ser Lys Ser Leu Lys Ser Gln Ile Ala Glu Ala Lys 
            180                 185                 190         


Ile Ile Cys Lys Thr Phe Lys Met Ser Glu Glu Arg Arg Ala Ile Ala 
        195                 200                 205             


Ile Lys Asp Ala Leu Asn Glu Asn Ser Gln Leu Gln Thr Ser His Lys 
    210                 215                 220                 


Gln Leu Phe Gln Gln Glu Ala Glu Val Trp Lys Gly Gln Val Ser Glu 
225                 230                 235                 240 


Leu Asn Lys Gln Lys Ile Thr Phe Glu Asp Ser Lys Val His Ala Glu 
                245                 250                 255     


Gln Val Leu Asn Asp Lys Glu Asn His Ile Lys Thr Leu Thr Gly His 
            260                 265                 270         


Leu Pro Met Met Lys Asp Gln Ala Ala Val Leu Glu Glu Asp Thr Thr 
        275                 280                 285             


Asp Asp Asp Asn Leu Glu Leu Lys Val Asn Ser Gln Trp Glu Asn Gly 
    290                 295                 300                 


Ala Asn Leu Asp Asp Pro Pro Lys Gly Ala Leu Lys Lys Leu Ile His 
305                 310                 315                 320 


Ala Ala Lys Leu Asn Val Ser Leu Lys Ser Leu Glu Gly Glu Arg Asn 
                325                 330                 335     


His Ile Ile Ile Gln Leu Ser Glu Val Asp Lys Thr Lys Glu Glu Leu 
            340                 345                 350         


Thr Glu His Ile Lys Asn Leu Gln Thr Gln Gln Ala Ser Leu Gln Ser 
        355                 360                 365             


Glu Asn Ile Tyr Phe Glu Ser Glu Asn Gln Lys Leu Gln Gln Lys Leu 
    370                 375                 380                 


Lys Ile Met Thr Glu Phe Tyr Gln Glu Asn Glu Met Lys Leu Tyr Arg 
385                 390                 395                 400 


Lys Leu Thr Val Glu Glu Asn Tyr Arg Ile Glu Glu Glu Glu Lys Leu 
                405                 410                 415     


Ser Arg Val Glu Glu Lys Ile Ser His Ala Thr Glu Glu Leu Glu Thr 
            420                 425                 430         


Tyr Arg Lys Leu Ala Lys Asp Leu Glu Glu Glu Leu Glu Arg Thr Val 
        435                 440                 445             


His Phe Tyr Gln Lys Gln Val Ile Ser Tyr Glu Lys Arg Gly His Asp 
    450                 455                 460                 


Asn Trp Leu Ala Ala Arg Thr Ala Glu Arg Asn Leu Ser Asp Leu Arg 
465                 470                 475                 480 


Lys Glu Asn Ala His Asn Lys Gln Lys Leu Thr Glu Arg Glu Leu Lys 
                485                 490                 495     


Phe Glu Leu Leu Glu Lys Asp Pro Asn Ala Leu Asp Val Ser Asn Thr 
            500                 505                 510         


Ala Phe Gly Arg Glu His Ser Pro Cys Ser Pro Ser Pro Leu Gly Arg 
        515                 520                 525             


Pro Ser Ser Glu Thr Arg Ala Phe Pro Ser Pro Gln Thr Leu Leu Glu 
    530                 535                 540                 


Asp Pro Leu Arg Leu Ser Pro Val Leu Pro Gly Gly Gly Gly Arg Gly 
545                 550                 555                 560 


Pro Ser Ser Pro Gly Asn Pro Leu Asp His Gln Ile Thr Asn Glu Arg 
                565                 570                 575     


Gly Glu Pro Ser Tyr Asp Arg Leu Ile Asp Pro His Arg Ala Pro Ser 
            580                 585                 590         


Asp Thr Gly Ser Leu Ser Ser Pro Val Glu Gln Asp Arg Arg Met Met 
        595                 600                 605             


Phe Pro Pro Pro Gly Gln Ser Tyr Pro Asp Ser Thr Leu Pro Pro Gln 
    610                 615                 620                 


Arg Glu Asp Arg Phe Tyr Ser Asn Ser Glu Arg Leu Ser Gly Pro Ala 
625                 630                 635                 640 


Glu Pro Arg Ser Phe Lys Met Thr Ser Leu Asp Lys Met Asp Arg Ser 
                645                 650                 655     


Met Pro Ser Glu Met Glu Ser Ser Arg Asn Asp Ala Lys Asp Asp Leu 
            660                 665                 670         


Gly Asn Leu Asn Val Pro Asp Ser Ser Leu Pro Ala Glu Asn Glu Ala 
        675                 680                 685             


Thr Gly Pro Gly Leu Ile Pro Pro Pro Leu Ala Pro Ile Ser Gly Pro 
    690                 695                 700                 


Leu Phe Pro Val Asp Thr Arg Gly Pro Phe Met Arg Arg Gly Pro Pro 
705                 710                 715                 720 


Phe Pro Pro Pro Pro Pro Gly Thr Met Phe Gly Ala Ser Arg Gly Tyr 
                725                 730                 735     


Phe Pro Pro Arg Asp Phe Pro Gly Pro Pro His Ala Pro Phe Ala Met 
            740                 745                 750         


Arg Asn Ile Tyr Pro Pro Arg Gly Leu Pro Pro Tyr Leu His Pro Arg 
        755                 760                 765             


Pro Gly Phe Tyr Pro Asn Pro Thr Phe 
    770                 775         


<210>  1874
<211>  1192
<212>  PRT
<213>  Homo sapiens

<400>  1874

Met Ala Ala Cys Gly Arg Val Arg Arg Met Phe Arg Leu Ser Ala Ala 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Phe Ala Ala Gly Ala Glu Lys Leu Pro Gly 
            20                  25                  30          


Gln Gly Val His Ser Gln Gly Gln Gly Pro Gly Ala Asn Phe Val Ser 
        35                  40                  45              


Phe Val Gly Gln Ala Gly Gly Gly Gly Pro Ala Gly Gln Gln Leu Pro 
    50                  55                  60                  


Gln Leu Pro Gln Ser Ser Gln Leu Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Gln Gln Gln Gln Pro Gln Pro Pro Gln Pro Pro Phe Pro Ala Gly Gly 
                85                  90                  95      


Pro Pro Ala Arg Arg Gly Gly Ala Gly Ala Gly Gly Gly Trp Lys Leu 
            100                 105                 110         


Ala Glu Glu Glu Ser Cys Arg Glu Asp Val Thr Arg Val Cys Pro Lys 
        115                 120                 125             


His Thr Trp Ser Asn Asn Leu Ala Val Leu Glu Cys Leu Gln Asp Val 
    130                 135                 140                 


Arg Glu Leu Leu Trp Asn Tyr Lys Leu Asn Leu Thr Thr Asp Pro Lys 
145                 150                 155                 160 


Phe Glu Ser Val Ala Arg Glu Val Cys Lys Ser Thr Ile Thr Glu Ile 
                165                 170                 175     


Lys Glu Cys Ala Asp Glu Pro Val Gly Lys Gly Tyr Met Val Ser Cys 
            180                 185                 190         


Leu Val Asp His Arg Gly Asn Ile Thr Glu Tyr Gln Cys His Gln Tyr 
        195                 200                 205             


Ile Thr Lys Met Thr Ala Ile Ile Phe Ser Asp Tyr Arg Leu Ile Cys 
    210                 215                 220                 


Gly Phe Met Asp Asp Cys Lys Asn Asp Ile Asn Ile Leu Lys Cys Gly 
225                 230                 235                 240 


Ser Ile Arg Leu Gly Glu Lys Asp Ala His Ser Gln Gly Glu Val Val 
                245                 250                 255     


Ser Cys Leu Glu Lys Gly Leu Val Lys Glu Ala Glu Glu Arg Glu Pro 
            260                 265                 270         


Lys Ile Gln Val Ser Glu Leu Cys Lys Lys Ala Ile Leu Arg Val Ala 
        275                 280                 285             


Glu Leu Ser Ser Asp Asp Phe His Leu Asp Arg His Leu Tyr Phe Ala 
    290                 295                 300                 


Cys Arg Asp Asp Arg Glu Arg Phe Cys Glu Asn Thr Gln Ala Gly Glu 
305                 310                 315                 320 


Gly Arg Val Tyr Lys Cys Leu Phe Asn His Lys Phe Glu Glu Ser Met 
                325                 330                 335     


Ser Glu Lys Cys Arg Glu Ala Leu Thr Thr Arg Gln Lys Leu Ile Ala 
            340                 345                 350         


Gln Asp Tyr Lys Val Ser Tyr Ser Leu Ala Lys Ser Cys Lys Ser Asp 
        355                 360                 365             


Leu Lys Lys Tyr Arg Cys Asn Val Glu Asn Leu Pro Arg Ser Arg Glu 
    370                 375                 380                 


Ala Arg Leu Ser Tyr Leu Leu Met Cys Leu Glu Ser Ala Val His Arg 
385                 390                 395                 400 


Gly Arg Gln Val Ser Ser Glu Cys Gln Gly Glu Met Leu Asp Tyr Arg 
                405                 410                 415     


Arg Met Leu Met Glu Asp Phe Ser Leu Ser Pro Glu Ile Ile Leu Ser 
            420                 425                 430         


Cys Arg Gly Glu Ile Glu His His Cys Ser Gly Leu His Arg Lys Gly 
        435                 440                 445             


Arg Thr Leu His Cys Leu Met Lys Val Val Arg Gly Glu Lys Gly Asn 
    450                 455                 460                 


Leu Gly Met Asn Cys Gln Gln Ala Leu Gln Thr Leu Ile Gln Glu Thr 
465                 470                 475                 480 


Asp Pro Gly Ala Asp Tyr Arg Ile Asp Arg Ala Leu Asn Glu Ala Cys 
                485                 490                 495     


Glu Ser Val Ile Gln Thr Ala Cys Lys His Ile Arg Ser Gly Asp Pro 
            500                 505                 510         


Met Ile Leu Ser Cys Leu Met Glu His Leu Tyr Thr Glu Lys Met Val 
        515                 520                 525             


Glu Asp Cys Glu His Arg Leu Leu Glu Leu Gln Tyr Phe Ile Ser Arg 
    530                 535                 540                 


Asp Trp Lys Leu Asp Pro Val Leu Tyr Arg Lys Cys Gln Gly Asp Ala 
545                 550                 555                 560 


Ser Arg Leu Cys His Thr His Gly Trp Asn Glu Thr Ser Glu Phe Met 
                565                 570                 575     


Pro Gln Gly Ala Val Phe Ser Cys Leu Tyr Arg His Ala Tyr Arg Thr 
            580                 585                 590         


Glu Glu Gln Gly Arg Arg Leu Ser Arg Glu Cys Arg Ala Glu Val Gln 
        595                 600                 605             


Arg Ile Leu His Gln Arg Ala Met Asp Val Lys Leu Asp Pro Ala Leu 
    610                 615                 620                 


Gln Asp Lys Cys Leu Ile Asp Leu Gly Lys Trp Cys Ser Glu Lys Thr 
625                 630                 635                 640 


Glu Thr Gly Gln Glu Leu Glu Cys Leu Gln Asp His Leu Asp Asp Leu 
                645                 650                 655     


Val Val Glu Cys Arg Asp Ile Val Gly Asn Leu Thr Glu Leu Glu Ser 
            660                 665                 670         


Glu Asp Ile Gln Ile Glu Ala Leu Leu Met Arg Ala Cys Glu Pro Ile 
        675                 680                 685             


Ile Gln Asn Phe Cys His Asp Val Ala Asp Asn Gln Ile Asp Ser Gly 
    690                 695                 700                 


Asp Leu Met Glu Cys Leu Ile Gln Asn Lys His Gln Lys Asp Met Asn 
705                 710                 715                 720 


Glu Lys Cys Ala Ile Gly Val Thr His Phe Gln Leu Val Gln Met Lys 
                725                 730                 735     


Asp Phe Arg Phe Ser Tyr Lys Phe Lys Met Ala Cys Lys Glu Asp Val 
            740                 745                 750         


Leu Lys Leu Cys Pro Asn Ile Lys Lys Lys Val Asp Val Val Ile Cys 
        755                 760                 765             


Leu Ser Thr Thr Val Arg Asn Asp Thr Leu Gln Glu Ala Lys Glu His 
    770                 775                 780                 


Arg Val Ser Leu Lys Cys Arg Arg Gln Leu Arg Val Glu Glu Leu Glu 
785                 790                 795                 800 


Met Thr Glu Asp Ile Arg Leu Glu Pro Asp Leu Tyr Glu Ala Cys Lys 
                805                 810                 815     


Ser Asp Ile Lys Asn Phe Cys Ser Ala Val Gln Tyr Gly Asn Ala Gln 
            820                 825                 830         


Ile Ile Glu Cys Leu Lys Glu Asn Lys Lys Gln Leu Ser Thr Arg Cys 
        835                 840                 845             


His Gln Lys Val Phe Lys Leu Gln Glu Thr Glu Met Met Asp Pro Glu 
    850                 855                 860                 


Leu Asp Tyr Thr Leu Met Arg Val Cys Lys Gln Met Ile Lys Arg Phe 
865                 870                 875                 880 


Cys Pro Glu Ala Asp Ser Lys Thr Met Leu Gln Cys Leu Lys Gln Asn 
                885                 890                 895     


Lys Asn Ser Glu Leu Met Asp Pro Lys Cys Lys Gln Met Ile Thr Lys 
            900                 905                 910         


Arg Gln Ile Thr Gln Asn Thr Asp Tyr Arg Leu Asn Pro Met Leu Arg 
        915                 920                 925             


Lys Ala Cys Lys Ala Asp Ile Pro Lys Phe Cys His Gly Ile Leu Thr 
    930                 935                 940                 


Lys Ala Lys Asp Asp Ser Glu Leu Glu Gly Gln Val Ile Ser Cys Leu 
945                 950                 955                 960 


Lys Leu Arg Tyr Ala Asp Gln Arg Leu Ser Ser Asp Cys Glu Asp Gln 
                965                 970                 975     


Ile Arg Ile Ile Ile Gln Glu Ser Ala Leu Asp Tyr Arg Leu Asp Pro 
            980                 985                 990         


Gln Leu Gln Leu His Cys Ser Asp  Glu Ile Ser Ser Leu  Cys Ala Glu 
        995                 1000                 1005             


Glu Ala  Ala Ala Gln Glu Gln  Thr Gly Gln Val Glu  Glu Cys Leu 
    1010                 1015                 1020             


Lys Val  Asn Leu Leu Lys Ile  Lys Thr Glu Leu Cys  Lys Lys Glu 
    1025                 1030                 1035             


Val Leu  Asn Met Leu Lys Glu  Ser Lys Ala Asp Ile  Phe Val Asp 
    1040                 1045                 1050             


Pro Val  Leu His Thr Ala Cys  Ala Leu Asp Ile Lys  His His Cys 
    1055                 1060                 1065             


Ala Ala  Ile Thr Pro Gly Arg  Gly Arg Gln Met Ser  Cys Leu Met 
    1070                 1075                 1080             


Glu Ala  Leu Glu Asp Lys Arg  Val Arg Leu Gln Pro  Glu Cys Lys 
    1085                 1090                 1095             


Lys Arg  Leu Asn Asp Arg Ile  Glu Met Trp Ser Tyr  Ala Ala Lys 
    1100                 1105                 1110             


Val Ala  Pro Ala Asp Gly Phe  Ser Asp Leu Ala Met  Gln Val Met 
    1115                 1120                 1125             


Thr Ser  Pro Ser Lys Asn Tyr  Ile Leu Ser Val Ile  Ser Gly Ser 
    1130                 1135                 1140             


Ile Cys  Ile Leu Phe Leu Ile  Gly Leu Met Cys Gly  Arg Ile Thr 
    1145                 1150                 1155             


Lys Arg  Val Thr Arg Glu Leu  Lys Asp Arg Leu Gln  Tyr Arg Ser 
    1160                 1165                 1170             


Glu Thr  Met Ala Tyr Lys Gly  Leu Val Trp Ser Gln  Asp Val Thr 
    1175                 1180                 1185             


Gly Ser  Pro Ala 
    1190         


<210>  1875
<211>  1179
<212>  PRT
<213>  Homo sapiens

<400>  1875

Met Ala Ala Cys Gly Arg Val Arg Arg Met Phe Arg Leu Ser Ala Ala 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Phe Ala Ala Gly Ala Glu Lys Leu Pro Gly 
            20                  25                  30          


Gln Gly Val His Ser Gln Gly Gln Gly Pro Gly Ala Asn Phe Val Ser 
        35                  40                  45              


Phe Val Gly Gln Ala Gly Gly Gly Gly Pro Ala Gly Gln Gln Leu Pro 
    50                  55                  60                  


Gln Leu Pro Gln Ser Ser Gln Leu Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Gln Gln Gln Gln Pro Gln Pro Pro Gln Pro Pro Phe Pro Ala Gly Gly 
                85                  90                  95      


Pro Pro Ala Arg Arg Gly Gly Ala Gly Ala Gly Gly Gly Trp Lys Leu 
            100                 105                 110         


Ala Glu Glu Glu Ser Cys Arg Glu Asp Val Thr Arg Val Cys Pro Lys 
        115                 120                 125             


His Thr Trp Ser Asn Asn Leu Ala Val Leu Glu Cys Leu Gln Asp Val 
    130                 135                 140                 


Arg Glu Pro Glu Asn Glu Ile Ser Ser Asp Cys Asn His Leu Leu Trp 
145                 150                 155                 160 


Asn Tyr Lys Leu Asn Leu Thr Thr Asp Pro Lys Phe Glu Ser Val Ala 
                165                 170                 175     


Arg Glu Val Cys Lys Ser Thr Ile Thr Glu Ile Lys Glu Cys Ala Asp 
            180                 185                 190         


Glu Pro Val Gly Lys Gly Tyr Met Val Ser Cys Leu Val Asp His Arg 
        195                 200                 205             


Gly Asn Ile Thr Glu Tyr Gln Cys His Gln Tyr Ile Thr Lys Met Thr 
    210                 215                 220                 


Ala Ile Ile Phe Ser Asp Tyr Arg Leu Ile Cys Gly Phe Met Asp Asp 
225                 230                 235                 240 


Cys Lys Asn Asp Ile Asn Ile Leu Lys Cys Gly Ser Ile Arg Leu Gly 
                245                 250                 255     


Glu Lys Asp Ala His Ser Gln Gly Glu Val Val Ser Cys Leu Glu Lys 
            260                 265                 270         


Gly Leu Val Lys Glu Ala Glu Glu Arg Glu Pro Lys Ile Gln Val Ser 
        275                 280                 285             


Glu Leu Cys Lys Lys Ala Ile Leu Arg Val Ala Glu Leu Ser Ser Asp 
    290                 295                 300                 


Asp Phe His Leu Asp Arg His Leu Tyr Phe Ala Cys Arg Asp Asp Arg 
305                 310                 315                 320 


Glu Arg Phe Cys Glu Asn Thr Gln Ala Gly Glu Gly Arg Val Tyr Lys 
                325                 330                 335     


Cys Leu Phe Asn His Lys Phe Glu Glu Ser Met Ser Glu Lys Cys Arg 
            340                 345                 350         


Glu Ala Leu Thr Thr Arg Gln Lys Leu Ile Ala Gln Asp Tyr Lys Val 
        355                 360                 365             


Ser Tyr Ser Leu Ala Lys Ser Cys Lys Ser Asp Leu Lys Lys Tyr Arg 
    370                 375                 380                 


Cys Asn Val Glu Asn Leu Pro Arg Ser Arg Glu Ala Arg Leu Ser Tyr 
385                 390                 395                 400 


Leu Leu Met Cys Leu Glu Ser Ala Val His Arg Gly Arg Gln Val Ser 
                405                 410                 415     


Ser Glu Cys Gln Gly Glu Met Leu Asp Tyr Arg Arg Met Leu Met Glu 
            420                 425                 430         


Asp Phe Ser Leu Ser Pro Glu Ile Ile Leu Ser Cys Arg Gly Glu Ile 
        435                 440                 445             


Glu His His Cys Ser Gly Leu His Arg Lys Gly Arg Thr Leu His Cys 
    450                 455                 460                 


Leu Met Lys Val Val Arg Gly Glu Lys Gly Asn Leu Gly Met Asn Cys 
465                 470                 475                 480 


Gln Gln Ala Leu Gln Thr Leu Ile Gln Glu Thr Asp Pro Gly Ala Asp 
                485                 490                 495     


Tyr Arg Ile Asp Arg Ala Leu Asn Glu Ala Cys Glu Ser Val Ile Gln 
            500                 505                 510         


Thr Ala Cys Lys His Ile Arg Ser Gly Asp Pro Met Ile Leu Ser Cys 
        515                 520                 525             


Leu Met Glu His Leu Tyr Thr Glu Lys Met Val Glu Asp Cys Glu His 
    530                 535                 540                 


Arg Leu Leu Glu Leu Gln Tyr Phe Ile Ser Arg Asp Trp Lys Leu Asp 
545                 550                 555                 560 


Pro Val Leu Tyr Arg Lys Cys Gln Gly Asp Ala Ser Arg Leu Cys His 
                565                 570                 575     


Thr His Gly Trp Asn Glu Thr Ser Glu Phe Met Pro Gln Gly Ala Val 
            580                 585                 590         


Phe Ser Cys Leu Tyr Arg His Ala Tyr Arg Thr Glu Glu Gln Gly Arg 
        595                 600                 605             


Arg Leu Ser Arg Glu Cys Arg Ala Glu Val Gln Arg Ile Leu His Gln 
    610                 615                 620                 


Arg Ala Met Asp Val Lys Leu Asp Pro Ala Leu Gln Asp Lys Cys Leu 
625                 630                 635                 640 


Ile Asp Leu Gly Lys Trp Cys Ser Glu Lys Thr Glu Thr Gly Gln Glu 
                645                 650                 655     


Leu Glu Cys Leu Gln Asp His Leu Asp Asp Leu Val Val Glu Cys Arg 
            660                 665                 670         


Asp Ile Val Gly Asn Leu Thr Glu Leu Glu Ser Glu Asp Ile Gln Ile 
        675                 680                 685             


Glu Ala Leu Leu Met Arg Ala Cys Glu Pro Ile Ile Gln Asn Phe Cys 
    690                 695                 700                 


His Asp Val Ala Asp Asn Gln Ile Asp Ser Gly Asp Leu Met Glu Cys 
705                 710                 715                 720 


Leu Ile Gln Asn Lys His Gln Lys Asp Met Asn Glu Lys Cys Ala Ile 
                725                 730                 735     


Gly Val Thr His Phe Gln Leu Val Gln Met Lys Asp Phe Arg Phe Ser 
            740                 745                 750         


Tyr Lys Phe Lys Met Ala Cys Lys Glu Asp Val Leu Lys Leu Cys Pro 
        755                 760                 765             


Asn Ile Lys Lys Lys Val Asp Val Val Ile Cys Leu Ser Thr Thr Val 
    770                 775                 780                 


Arg Asn Asp Thr Leu Gln Glu Ala Lys Glu His Arg Val Ser Leu Lys 
785                 790                 795                 800 


Cys Arg Arg Gln Leu Arg Val Glu Glu Leu Glu Met Thr Glu Asp Ile 
                805                 810                 815     


Arg Leu Glu Pro Asp Leu Tyr Glu Ala Cys Lys Ser Asp Ile Lys Asn 
            820                 825                 830         


Phe Cys Ser Ala Val Gln Tyr Gly Asn Ala Gln Ile Ile Glu Cys Leu 
        835                 840                 845             


Lys Glu Asn Lys Lys Gln Leu Ser Thr Arg Cys His Gln Lys Val Phe 
    850                 855                 860                 


Lys Leu Gln Glu Thr Glu Met Met Asp Pro Glu Leu Asp Tyr Thr Leu 
865                 870                 875                 880 


Met Arg Val Cys Lys Gln Met Ile Lys Arg Phe Cys Pro Glu Ala Asp 
                885                 890                 895     


Ser Lys Thr Met Leu Gln Cys Leu Lys Gln Asn Lys Asn Ser Glu Leu 
            900                 905                 910         


Met Asp Pro Lys Cys Lys Gln Met Ile Thr Lys Arg Gln Ile Thr Gln 
        915                 920                 925             


Asn Thr Asp Tyr Arg Leu Asn Pro Met Leu Arg Lys Ala Cys Lys Ala 
    930                 935                 940                 


Asp Ile Pro Lys Phe Cys His Gly Ile Leu Thr Lys Ala Lys Asp Asp 
945                 950                 955                 960 


Ser Glu Leu Glu Gly Gln Val Ile Ser Cys Leu Lys Leu Arg Tyr Ala 
                965                 970                 975     


Asp Gln Arg Leu Ser Ser Asp Cys Glu Asp Gln Ile Arg Ile Ile Ile 
            980                 985                 990         


Gln Glu Ser Ala Leu Asp Tyr Arg  Leu Asp Pro Gln Leu  Gln Leu His 
        995                 1000                 1005             


Cys Ser  Asp Glu Ile Ser Ser  Leu Cys Ala Glu Glu  Ala Ala Ala 
    1010                 1015                 1020             


Gln Glu  Gln Thr Gly Gln Val  Glu Glu Cys Leu Lys  Val Asn Leu 
    1025                 1030                 1035             


Leu Lys  Ile Lys Thr Glu Leu  Cys Lys Lys Glu Val  Leu Asn Met 
    1040                 1045                 1050             


Leu Lys  Glu Ser Lys Ala Asp  Ile Phe Val Asp Pro  Val Leu His 
    1055                 1060                 1065             


Thr Ala  Cys Ala Leu Asp Ile  Lys His His Cys Ala  Ala Ile Thr 
    1070                 1075                 1080             


Pro Gly  Arg Gly Arg Gln Met  Ser Cys Leu Met Glu  Ala Leu Glu 
    1085                 1090                 1095             


Asp Lys  Arg Val Arg Leu Gln  Pro Glu Cys Lys Lys  Arg Leu Asn 
    1100                 1105                 1110             


Asp Arg  Ile Glu Met Trp Ser  Tyr Ala Ala Lys Val  Ala Pro Ala 
    1115                 1120                 1125             


Asp Gly  Phe Ser Asp Leu Ala  Met Gln Val Met Thr  Ser Pro Ser 
    1130                 1135                 1140             


Lys Asn  Tyr Ile Leu Ser Val  Ile Ser Gly Ser Ile  Cys Ile Leu 
    1145                 1150                 1155             


Phe Leu  Ile Gly Leu Met Cys  Gly Arg Ile Thr Lys  Arg Val Thr 
    1160                 1165                 1170             


Arg Glu  Leu Lys Asp Arg 
    1175                 


<210>  1876
<211>  489
<212>  PRT
<213>  Homo sapiens

<400>  1876

Met Val Ala Glu Arg Ser Pro Ala Arg Ser Pro Gly Ser Trp Leu Phe 
1               5                   10                  15      


Pro Gly Leu Trp Leu Leu Val Leu Ser Gly Pro Gly Gly Leu Leu Arg 
            20                  25                  30          


Ala Gln Glu Gln Pro Ser Cys Arg Arg Ala Phe Asp Leu Tyr Phe Val 
        35                  40                  45              


Leu Asp Lys Ser Gly Ser Val Ala Asn Asn Trp Ile Glu Ile Tyr Asn 
    50                  55                  60                  


Phe Val Gln Gln Leu Ala Glu Arg Phe Val Ser Pro Glu Met Arg Leu 
65                  70                  75                  80  


Ser Phe Ile Val Phe Ser Ser Gln Ala Thr Ile Ile Leu Pro Leu Thr 
                85                  90                  95      


Gly Asp Arg Gly Lys Ile Ser Lys Gly Leu Glu Asp Leu Lys Arg Val 
            100                 105                 110         


Ser Pro Val Gly Glu Thr Tyr Ile His Glu Gly Leu Lys Leu Ala Asn 
        115                 120                 125             


Glu Gln Ile Gln Lys Ala Gly Gly Leu Lys Thr Ser Ser Ile Ile Ile 
    130                 135                 140                 


Ala Leu Thr Asp Gly Lys Leu Asp Gly Leu Val Pro Ser Tyr Ala Glu 
145                 150                 155                 160 


Lys Glu Ala Lys Ile Ser Arg Ser Leu Gly Ala Ser Val Tyr Cys Val 
                165                 170                 175     


Gly Val Leu Asp Phe Glu Gln Ala Gln Leu Glu Arg Ile Ala Asp Ser 
            180                 185                 190         


Lys Glu Gln Val Phe Pro Val Lys Gly Gly Phe Gln Ala Leu Lys Gly 
        195                 200                 205             


Ile Ile Asn Ser Ile Leu Ala Gln Ser Cys Thr Glu Ile Leu Glu Leu 
    210                 215                 220                 


Gln Pro Ser Ser Val Cys Val Gly Glu Glu Phe Gln Ile Val Leu Ser 
225                 230                 235                 240 


Gly Arg Gly Phe Met Leu Gly Ser Arg Asn Gly Ser Val Leu Cys Thr 
                245                 250                 255     


Tyr Thr Val Asn Glu Thr Tyr Thr Thr Ser Val Lys Pro Val Ser Val 
            260                 265                 270         


Gln Leu Asn Ser Met Leu Cys Pro Ala Pro Ile Leu Asn Lys Ala Gly 
        275                 280                 285             


Glu Thr Leu Asp Val Ser Val Ser Phe Asn Gly Gly Lys Ser Val Ile 
    290                 295                 300                 


Ser Gly Ser Leu Ile Val Thr Ala Thr Glu Cys Ser Asn Gly Ile Ala 
305                 310                 315                 320 


Ala Ile Ile Val Ile Leu Val Leu Leu Leu Leu Leu Gly Ile Gly Leu 
                325                 330                 335     


Met Trp Trp Phe Trp Pro Leu Cys Cys Lys Val Val Ile Lys Asp Pro 
            340                 345                 350         


Pro Pro Pro Pro Ala Pro Ala Pro Lys Glu Glu Glu Glu Glu Pro Leu 
        355                 360                 365             


Pro Thr Lys Lys Trp Pro Thr Val Asp Ala Ser Tyr Tyr Gly Gly Arg 
    370                 375                 380                 


Gly Val Gly Gly Ile Lys Arg Met Glu Val Arg Trp Gly Asp Lys Gly 
385                 390                 395                 400 


Ser Thr Glu Glu Gly Ala Arg Leu Glu Lys Ala Lys Asn Ala Val Val 
                405                 410                 415     


Lys Ile Pro Glu Glu Thr Glu Glu Pro Ile Arg Pro Arg Pro Pro Arg 
            420                 425                 430         


Pro Lys Pro Thr His Gln Pro Pro Gln Thr Lys Trp Tyr Thr Pro Ile 
        435                 440                 445             


Lys Gly Arg Leu Asp Ala Leu Trp Ala Leu Leu Arg Arg Gln Tyr Asp 
    450                 455                 460                 


Arg Val Ser Leu Met Arg Pro Gln Glu Gly Asp Glu Val Cys Ile Trp 
465                 470                 475                 480 


Glu Cys Ile Glu Lys Glu Leu Thr Ala 
                485                 


<210>  1877
<211>  1153
<212>  PRT
<213>  Homo sapiens

<400>  1877

Met Ala Leu Arg Val Leu Leu Leu Thr Ala Leu Thr Leu Cys His Gly 
1               5                   10                  15      


Phe Asn Leu Asp Thr Glu Asn Ala Met Thr Phe Gln Glu Asn Ala Arg 
            20                  25                  30          


Gly Phe Gly Gln Ser Val Val Gln Leu Gln Gly Ser Arg Val Val Val 
        35                  40                  45              


Gly Ala Pro Gln Glu Ile Val Ala Ala Asn Gln Arg Gly Ser Leu Tyr 
    50                  55                  60                  


Gln Cys Asp Tyr Ser Thr Gly Ser Cys Glu Pro Ile Arg Leu Gln Val 
65                  70                  75                  80  


Pro Val Glu Ala Val Asn Met Ser Leu Gly Leu Ser Leu Ala Ala Thr 
                85                  90                  95      


Thr Ser Pro Pro Gln Leu Leu Ala Cys Gly Pro Thr Val His Gln Thr 
            100                 105                 110         


Cys Ser Glu Asn Thr Tyr Val Lys Gly Leu Cys Phe Leu Phe Gly Ser 
        115                 120                 125             


Asn Leu Arg Gln Gln Pro Gln Lys Phe Pro Glu Ala Leu Arg Gly Cys 
    130                 135                 140                 


Pro Gln Glu Asp Ser Asp Ile Ala Phe Leu Ile Asp Gly Ser Gly Ser 
145                 150                 155                 160 


Ile Ile Pro His Asp Phe Arg Arg Met Lys Glu Phe Val Ser Thr Val 
                165                 170                 175     


Met Glu Gln Leu Lys Lys Ser Lys Thr Leu Phe Ser Leu Met Gln Tyr 
            180                 185                 190         


Ser Glu Glu Phe Arg Ile His Phe Thr Phe Lys Glu Phe Gln Asn Asn 
        195                 200                 205             


Pro Asn Pro Arg Ser Leu Val Lys Pro Ile Thr Gln Leu Leu Gly Arg 
    210                 215                 220                 


Thr His Thr Ala Thr Gly Ile Arg Lys Val Val Arg Glu Leu Phe Asn 
225                 230                 235                 240 


Ile Thr Asn Gly Ala Arg Lys Asn Ala Phe Lys Ile Leu Val Val Ile 
                245                 250                 255     


Thr Asp Gly Glu Lys Phe Gly Asp Pro Leu Gly Tyr Glu Asp Val Ile 
            260                 265                 270         


Pro Glu Ala Asp Arg Glu Gly Val Ile Arg Tyr Val Ile Gly Val Gly 
        275                 280                 285             


Asp Ala Phe Arg Ser Glu Lys Ser Arg Gln Glu Leu Asn Thr Ile Ala 
    290                 295                 300                 


Ser Lys Pro Pro Arg Asp His Val Phe Gln Val Asn Asn Phe Glu Ala 
305                 310                 315                 320 


Leu Lys Thr Ile Gln Asn Gln Leu Arg Glu Lys Ile Phe Ala Ile Glu 
                325                 330                 335     


Gly Thr Gln Thr Gly Ser Ser Ser Ser Phe Glu His Glu Met Ser Gln 
            340                 345                 350         


Glu Gly Phe Ser Ala Ala Ile Thr Ser Asn Gly Pro Leu Leu Ser Thr 
        355                 360                 365             


Val Gly Ser Tyr Asp Trp Ala Gly Gly Val Phe Leu Tyr Thr Ser Lys 
    370                 375                 380                 


Glu Lys Ser Thr Phe Ile Asn Met Thr Arg Val Asp Ser Asp Met Asn 
385                 390                 395                 400 


Asp Ala Tyr Leu Gly Tyr Ala Ala Ala Ile Ile Leu Arg Asn Arg Val 
                405                 410                 415     


Gln Ser Leu Val Leu Gly Ala Pro Arg Tyr Gln His Ile Gly Leu Val 
            420                 425                 430         


Ala Met Phe Arg Gln Asn Thr Gly Met Trp Glu Ser Asn Ala Asn Val 
        435                 440                 445             


Lys Gly Thr Gln Ile Gly Ala Tyr Phe Gly Ala Ser Leu Cys Ser Val 
    450                 455                 460                 


Asp Val Asp Ser Asn Gly Ser Thr Asp Leu Val Leu Ile Gly Ala Pro 
465                 470                 475                 480 


His Tyr Tyr Glu Gln Thr Arg Gly Gly Gln Val Ser Val Cys Pro Leu 
                485                 490                 495     


Pro Arg Gly Gln Arg Ala Arg Trp Gln Cys Asp Ala Val Leu Tyr Gly 
            500                 505                 510         


Glu Gln Gly Gln Pro Trp Gly Arg Phe Gly Ala Ala Leu Thr Val Leu 
        515                 520                 525             


Gly Asp Val Asn Gly Asp Lys Leu Thr Asp Val Ala Ile Gly Ala Pro 
    530                 535                 540                 


Gly Glu Glu Asp Asn Arg Gly Ala Val Tyr Leu Phe His Gly Thr Ser 
545                 550                 555                 560 


Gly Ser Gly Ile Ser Pro Ser His Ser Gln Arg Ile Ala Gly Ser Lys 
                565                 570                 575     


Leu Ser Pro Arg Leu Gln Tyr Phe Gly Gln Ser Leu Ser Gly Gly Gln 
            580                 585                 590         


Asp Leu Thr Met Asp Gly Leu Val Asp Leu Thr Val Gly Ala Gln Gly 
        595                 600                 605             


His Val Leu Leu Leu Arg Ser Gln Pro Val Leu Arg Val Lys Ala Ile 
    610                 615                 620                 


Met Glu Phe Asn Pro Arg Glu Val Ala Arg Asn Val Phe Glu Cys Asn 
625                 630                 635                 640 


Asp Gln Val Val Lys Gly Lys Glu Ala Gly Glu Val Arg Val Cys Leu 
                645                 650                 655     


His Val Gln Lys Ser Thr Arg Asp Arg Leu Arg Glu Gly Gln Ile Gln 
            660                 665                 670         


Ser Val Val Thr Tyr Asp Leu Ala Leu Asp Ser Gly Arg Pro His Ser 
        675                 680                 685             


Arg Ala Val Phe Asn Glu Thr Lys Asn Ser Thr Arg Arg Gln Thr Gln 
    690                 695                 700                 


Val Leu Gly Leu Thr Gln Thr Cys Glu Thr Leu Lys Leu Gln Leu Pro 
705                 710                 715                 720 


Asn Cys Ile Glu Asp Pro Val Ser Pro Ile Val Leu Arg Leu Asn Phe 
                725                 730                 735     


Ser Leu Val Gly Thr Pro Leu Ser Ala Phe Gly Asn Leu Arg Pro Val 
            740                 745                 750         


Leu Ala Glu Asp Ala Gln Arg Leu Phe Thr Ala Leu Phe Pro Phe Glu 
        755                 760                 765             


Lys Asn Cys Gly Asn Asp Asn Ile Cys Gln Asp Asp Leu Ser Ile Thr 
    770                 775                 780                 


Phe Ser Phe Met Ser Leu Asp Cys Leu Val Val Gly Gly Pro Arg Glu 
785                 790                 795                 800 


Phe Asn Val Thr Val Thr Val Arg Asn Asp Gly Glu Asp Ser Tyr Arg 
                805                 810                 815     


Thr Gln Val Thr Phe Phe Phe Pro Leu Asp Leu Ser Tyr Arg Lys Val 
            820                 825                 830         


Ser Thr Leu Gln Asn Gln Arg Ser Gln Arg Ser Trp Arg Leu Ala Cys 
        835                 840                 845             


Glu Ser Ala Ser Ser Thr Glu Val Ser Gly Ala Leu Lys Ser Thr Ser 
    850                 855                 860                 


Cys Ser Ile Asn His Pro Ile Phe Pro Glu Asn Ser Glu Val Thr Phe 
865                 870                 875                 880 


Asn Ile Thr Phe Asp Val Asp Ser Lys Ala Ser Leu Gly Asn Lys Leu 
                885                 890                 895     


Leu Leu Lys Ala Asn Val Thr Ser Glu Asn Asn Met Pro Arg Thr Asn 
            900                 905                 910         


Lys Thr Glu Phe Gln Leu Glu Leu Pro Val Lys Tyr Ala Val Tyr Met 
        915                 920                 925             


Val Val Thr Ser His Gly Val Ser Thr Lys Tyr Leu Asn Phe Thr Ala 
    930                 935                 940                 


Ser Glu Asn Thr Ser Arg Val Met Gln His Gln Tyr Gln Val Ser Asn 
945                 950                 955                 960 


Leu Gly Gln Arg Ser Leu Pro Ile Ser Leu Val Phe Leu Val Pro Val 
                965                 970                 975     


Arg Leu Asn Gln Thr Val Ile Trp Asp Arg Pro Gln Val Thr Phe Ser 
            980                 985                 990         


Glu Asn Leu Ser Ser Thr Cys His  Thr Lys Glu Arg Leu  Pro Ser His 
        995                 1000                 1005             


Ser Asp  Phe Leu Ala Glu Leu  Arg Lys Ala Pro Val  Val Asn Cys 
    1010                 1015                 1020             


Ser Ile  Ala Val Cys Gln Arg  Ile Gln Cys Asp Ile  Pro Phe Phe 
    1025                 1030                 1035             


Gly Ile  Gln Glu Glu Phe Asn  Ala Thr Leu Lys Gly  Asn Leu Ser 
    1040                 1045                 1050             


Phe Asp  Trp Tyr Ile Lys Thr  Ser His Asn His Leu  Leu Ile Val 
    1055                 1060                 1065             


Ser Thr  Ala Glu Ile Leu Phe  Asn Asp Ser Val Phe  Thr Leu Leu 
    1070                 1075                 1080             


Pro Gly  Gln Gly Ala Phe Val  Arg Ser Gln Thr Glu  Thr Lys Val 
    1085                 1090                 1095             


Glu Pro  Phe Glu Val Pro Asn  Pro Leu Pro Leu Ile  Val Gly Ser 
    1100                 1105                 1110             


Ser Val  Gly Gly Leu Leu Leu  Leu Ala Leu Ile Thr  Ala Ala Leu 
    1115                 1120                 1125             


Tyr Lys  Leu Gly Phe Phe Lys  Arg Gln Tyr Lys Asp  Met Met Ser 
    1130                 1135                 1140             


Glu Gly  Gly Pro Pro Gly Ala  Glu Pro Gln 
    1145                 1150             


<210>  1878
<211>  856
<212>  PRT
<213>  Homo sapiens

<400>  1878

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15      


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30          


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45              


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60                  


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80  


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Ile Val Tyr Tyr 
                85                  90                  95      


Glu Ala Gly Ile Ile Leu Cys Cys Val Leu Gly Leu Leu Phe Ile Ile 
            100                 105                 110         


Leu Met Pro Leu Val Gly Tyr Phe Phe Cys Met Cys Arg Cys Cys Asn 
        115                 120                 125             


Lys Cys Gly Gly Glu Met His Gln Arg Gln Lys Glu Asn Gly Pro Phe 
    130                 135                 140                 


Leu Arg Lys Cys Phe Ala Ile Ser Leu Leu Val Ile Cys Ile Ile Ile 
145                 150                 155                 160 


Ser Ile Gly Ile Phe Tyr Gly Phe Val Ala Asn His Gln Val Arg Thr 
                165                 170                 175     


Arg Ile Lys Arg Ser Arg Lys Leu Ala Asp Ser Asn Phe Lys Asp Leu 
            180                 185                 190         


Arg Thr Leu Leu Asn Glu Thr Pro Glu Gln Ile Lys Tyr Ile Leu Ala 
        195                 200                 205             


Gln Tyr Asn Thr Thr Lys Asp Lys Ala Phe Thr Asp Leu Asn Ser Ile 
    210                 215                 220                 


Asn Ser Val Leu Gly Gly Gly Ile Leu Asp Arg Leu Arg Pro Asn Ile 
225                 230                 235                 240 


Ile Pro Val Leu Asp Glu Ile Lys Ser Met Ala Thr Ala Ile Lys Glu 
                245                 250                 255     


Thr Lys Glu Ala Leu Glu Asn Met Asn Ser Thr Leu Lys Ser Leu His 
            260                 265                 270         


Gln Gln Ser Thr Gln Leu Ser Ser Ser Leu Thr Ser Val Lys Thr Ser 
        275                 280                 285             


Leu Arg Ser Ser Leu Asn Asp Pro Leu Cys Leu Val His Pro Ser Ser 
    290                 295                 300                 


Glu Thr Cys Asn Ser Ile Arg Leu Ser Leu Ser Gln Leu Asn Ser Asn 
305                 310                 315                 320 


Pro Glu Leu Arg Gln Leu Pro Pro Val Asp Ala Glu Leu Asp Asn Val 
                325                 330                 335     


Asn Asn Val Leu Arg Thr Asp Leu Asp Gly Leu Val Gln Gln Gly Tyr 
            340                 345                 350         


Gln Ser Leu Asn Asp Ile Pro Asp Arg Val Gln Arg Gln Thr Thr Thr 
        355                 360                 365             


Val Val Ala Gly Ile Lys Arg Val Leu Asn Ser Ile Gly Ser Asp Ile 
    370                 375                 380                 


Asp Asn Val Thr Gln Arg Leu Pro Ile Gln Asp Ile Leu Ser Ala Phe 
385                 390                 395                 400 


Ser Val Tyr Val Asn Asn Thr Glu Ser Tyr Ile His Arg Asn Leu Pro 
                405                 410                 415     


Thr Leu Glu Glu Tyr Asp Ser Tyr Trp Trp Leu Gly Gly Leu Val Ile 
            420                 425                 430         


Cys Ser Leu Leu Thr Leu Ile Val Ile Phe Tyr Tyr Leu Gly Leu Leu 
        435                 440                 445             


Cys Gly Val Cys Gly Tyr Asp Arg His Ala Thr Pro Thr Thr Arg Gly 
    450                 455                 460                 


Cys Val Ser Asn Thr Gly Gly Val Phe Leu Met Val Gly Val Gly Leu 
465                 470                 475                 480 


Ser Phe Leu Phe Cys Trp Ile Leu Met Ile Ile Val Val Leu Thr Phe 
                485                 490                 495     


Val Phe Gly Ala Asn Val Glu Lys Leu Ile Cys Glu Pro Tyr Thr Ser 
            500                 505                 510         


Lys Glu Leu Phe Arg Val Leu Asp Thr Pro Tyr Leu Leu Asn Glu Asp 
        515                 520                 525             


Trp Glu Tyr Tyr Leu Ser Gly Lys Leu Phe Asn Lys Ser Lys Met Lys 
    530                 535                 540                 


Leu Thr Phe Glu Gln Val Tyr Ser Asp Cys Lys Lys Asn Arg Gly Thr 
545                 550                 555                 560 


Tyr Gly Thr Leu His Leu Gln Asn Ser Phe Asn Ile Ser Glu His Leu 
                565                 570                 575     


Asn Ile Asn Glu His Thr Gly Ser Ile Ser Ser Glu Leu Glu Ser Leu 
            580                 585                 590         


Lys Val Asn Leu Asn Ile Phe Leu Leu Gly Ala Ala Gly Arg Lys Asn 
        595                 600                 605             


Leu Gln Asp Phe Ala Ala Cys Gly Ile Asp Arg Met Asn Tyr Asp Ser 
    610                 615                 620                 


Tyr Leu Ala Gln Thr Gly Lys Ser Pro Ala Gly Val Asn Leu Leu Ser 
625                 630                 635                 640 


Phe Ala Tyr Asp Leu Glu Ala Lys Ala Asn Ser Leu Pro Pro Gly Asn 
                645                 650                 655     


Leu Arg Asn Ser Leu Lys Arg Asp Ala Gln Thr Ile Lys Thr Ile His 
            660                 665                 670         


Gln Gln Arg Val Leu Pro Ile Glu Gln Ser Leu Ser Thr Leu Tyr Gln 
        675                 680                 685             


Ser Val Lys Ile Leu Gln Arg Thr Gly Asn Gly Leu Leu Glu Arg Val 
    690                 695                 700                 


Thr Arg Ile Leu Ala Ser Leu Asp Phe Ala Gln Asn Phe Ile Thr Asn 
705                 710                 715                 720 


Asn Thr Ser Ser Val Ile Ile Glu Glu Thr Lys Lys Tyr Gly Arg Thr 
                725                 730                 735     


Ile Ile Gly Tyr Phe Glu His Tyr Leu Gln Trp Ile Glu Phe Ser Ile 
            740                 745                 750         


Ser Glu Lys Val Ala Ser Cys Lys Pro Val Ala Thr Ala Leu Asp Thr 
        755                 760                 765             


Ala Val Asp Val Phe Leu Cys Ser Tyr Ile Ile Asp Pro Leu Asn Leu 
    770                 775                 780                 


Phe Trp Phe Gly Ile Gly Lys Ala Thr Val Phe Leu Leu Pro Ala Leu 
785                 790                 795                 800 


Ile Phe Ala Val Lys Leu Ala Lys Tyr Tyr Arg Arg Met Asp Ser Glu 
                805                 810                 815     


Asp Val Tyr Asp Asp Val Glu Thr Ile Pro Met Lys Asn Met Glu Asn 
            820                 825                 830         


Gly Asn Asn Gly Tyr His Lys Asp His Val Tyr Gly Ile His Asn Pro 
        835                 840                 845             


Val Met Thr Ser Pro Ser Gln His 
    850                 855     


<210>  1879
<211>  856
<212>  PRT
<213>  Homo sapiens

<400>  1879

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15      


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30          


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45              


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60                  


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80  


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Ile Val Tyr Tyr 
                85                  90                  95      


Glu Ala Gly Ile Ile Leu Cys Cys Val Leu Gly Leu Leu Phe Ile Ile 
            100                 105                 110         


Leu Met Pro Leu Val Gly Tyr Phe Phe Cys Met Cys Arg Cys Cys Asn 
        115                 120                 125             


Lys Cys Gly Gly Glu Met His Gln Arg Gln Lys Glu Asn Gly Pro Phe 
    130                 135                 140                 


Leu Arg Lys Cys Phe Ala Ile Ser Leu Leu Val Ile Cys Ile Ile Ile 
145                 150                 155                 160 


Ser Ile Gly Ile Phe Tyr Gly Phe Val Ala Asn His Gln Val Arg Thr 
                165                 170                 175     


Arg Ile Lys Arg Ser Arg Lys Leu Ala Asp Ser Asn Phe Lys Asp Leu 
            180                 185                 190         


Arg Thr Leu Leu Asn Glu Thr Pro Glu Gln Ile Lys Tyr Ile Leu Ala 
        195                 200                 205             


Gln Tyr Asn Thr Thr Lys Asp Lys Ala Phe Thr Asp Leu Asn Ser Ile 
    210                 215                 220                 


Asn Ser Val Leu Gly Gly Gly Ile Leu Asp Arg Leu Arg Pro Asn Ile 
225                 230                 235                 240 


Ile Pro Val Leu Asp Glu Ile Lys Ser Met Ala Thr Ala Ile Lys Glu 
                245                 250                 255     


Thr Lys Glu Ala Leu Glu Asn Met Asn Ser Thr Leu Lys Ser Leu His 
            260                 265                 270         


Gln Gln Ser Thr Gln Leu Ser Ser Ser Leu Thr Ser Val Lys Thr Ser 
        275                 280                 285             


Leu Arg Ser Ser Leu Asn Asp Pro Leu Cys Leu Val His Pro Ser Ser 
    290                 295                 300                 


Glu Thr Cys Asn Ser Ile Arg Leu Ser Leu Ser Gln Leu Asn Ser Asn 
305                 310                 315                 320 


Pro Glu Leu Arg Gln Leu Pro Pro Val Asp Ala Glu Leu Asp Asn Val 
                325                 330                 335     


Asn Asn Val Leu Arg Thr Asp Leu Asp Gly Leu Val Gln Gln Gly Tyr 
            340                 345                 350         


Gln Ser Leu Asn Asp Ile Pro Asp Arg Val Gln Arg Gln Thr Thr Thr 
        355                 360                 365             


Val Val Ala Gly Ile Lys Arg Val Leu Asn Ser Ile Gly Ser Asp Ile 
    370                 375                 380                 


Asp Asn Val Thr Gln Arg Leu Pro Ile Gln Asp Ile Leu Ser Ala Phe 
385                 390                 395                 400 


Ser Val Tyr Val Asn Asn Thr Glu Ser Tyr Ile His Arg Asn Leu Pro 
                405                 410                 415     


Thr Leu Glu Glu Tyr Asp Ser Tyr Trp Trp Leu Gly Gly Leu Val Ile 
            420                 425                 430         


Cys Ser Leu Leu Thr Leu Ile Val Ile Phe Tyr Tyr Leu Gly Leu Leu 
        435                 440                 445             


Cys Gly Val Cys Gly Tyr Asp Arg His Ala Thr Pro Thr Thr Arg Gly 
    450                 455                 460                 


Cys Val Ser Asn Thr Gly Gly Val Phe Leu Met Val Gly Val Gly Leu 
465                 470                 475                 480 


Ser Phe Leu Phe Cys Trp Ile Leu Met Ile Ile Val Val Leu Thr Phe 
                485                 490                 495     


Val Phe Gly Ala Asn Val Glu Lys Leu Ile Cys Glu Pro Tyr Thr Ser 
            500                 505                 510         


Lys Glu Leu Phe Arg Val Leu Asp Thr Pro Tyr Leu Leu Asn Glu Asp 
        515                 520                 525             


Trp Glu Tyr Tyr Leu Ser Gly Lys Leu Phe Asn Lys Ser Lys Met Lys 
    530                 535                 540                 


Leu Thr Phe Glu Gln Val Tyr Ser Asp Cys Lys Lys Asn Arg Gly Thr 
545                 550                 555                 560 


Tyr Gly Thr Leu His Leu Gln Asn Ser Phe Asn Ile Ser Glu His Leu 
                565                 570                 575     


Asn Ile Asn Glu His Thr Gly Ser Ile Ser Ser Glu Leu Glu Ser Leu 
            580                 585                 590         


Lys Val Asn Leu Asn Ile Phe Leu Leu Gly Ala Ala Gly Arg Lys Asn 
        595                 600                 605             


Leu Gln Asp Phe Ala Ala Cys Gly Ile Asp Arg Met Asn Tyr Asp Ser 
    610                 615                 620                 


Tyr Leu Ala Gln Thr Gly Lys Ser Pro Ala Gly Val Asn Leu Leu Ser 
625                 630                 635                 640 


Phe Ala Tyr Asp Leu Glu Ala Lys Ala Asn Ser Leu Pro Pro Gly Asn 
                645                 650                 655     


Leu Arg Asn Ser Leu Lys Arg Asp Ala Gln Thr Ile Lys Thr Ile His 
            660                 665                 670         


Gln Gln Arg Val Leu Pro Ile Glu Gln Ser Leu Ser Thr Leu Tyr Gln 
        675                 680                 685             


Ser Val Lys Ile Leu Gln Arg Thr Gly Asn Gly Leu Leu Glu Arg Val 
    690                 695                 700                 


Thr Arg Ile Leu Ala Ser Leu Asp Phe Ala Gln Asn Phe Ile Thr Asn 
705                 710                 715                 720 


Asn Thr Ser Ser Val Ile Ile Glu Glu Thr Lys Lys Tyr Gly Arg Thr 
                725                 730                 735     


Ile Ile Gly Tyr Phe Glu His Tyr Leu Gln Trp Ile Glu Phe Ser Ile 
            740                 745                 750         


Ser Glu Lys Val Ala Ser Cys Lys Pro Val Ala Thr Ala Leu Asp Thr 
        755                 760                 765             


Ala Val Asp Val Phe Leu Cys Ser Tyr Ile Ile Asp Pro Leu Asn Leu 
    770                 775                 780                 


Phe Trp Phe Gly Ile Gly Lys Ala Thr Val Phe Leu Leu Pro Ala Leu 
785                 790                 795                 800 


Ile Phe Ala Val Lys Leu Ala Lys Tyr Tyr Arg Arg Met Asp Ser Glu 
                805                 810                 815     


Asp Val Tyr Asp Asp Val Glu Thr Ile Pro Met Lys Asn Met Glu Asn 
            820                 825                 830         


Gly Asn Asn Gly Tyr His Lys Asp His Val Tyr Gly Ile His Asn Pro 
        835                 840                 845             


Val Met Thr Ser Pro Ser Gln His 
    850                 855     


<210>  1880
<211>  842
<212>  PRT
<213>  Homo sapiens

<400>  1880

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15      


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30          


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45              


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60                  


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80  


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Pro Glu Thr Val 
                85                  90                  95      


Ile Leu Gly Leu Lys Ile Val Tyr Tyr Glu Ala Gly Ile Ile Leu Cys 
            100                 105                 110         


Cys Val Leu Gly Leu Leu Phe Ile Ile Leu Met Pro Leu Val Gly Tyr 
        115                 120                 125             


Phe Phe Cys Met Cys Arg Cys Cys Asn Lys Cys Gly Gly Glu Met His 
    130                 135                 140                 


Gln Arg Gln Lys Glu Asn Gly Pro Phe Leu Arg Lys Cys Phe Ala Ile 
145                 150                 155                 160 


Ser Leu Leu Val Ile Cys Ile Ile Ile Ser Ile Gly Ile Phe Tyr Gly 
                165                 170                 175     


Phe Val Ala Asn His Gln Val Arg Thr Arg Ile Lys Arg Ser Arg Lys 
            180                 185                 190         


Leu Ala Asp Ser Asn Phe Lys Asp Leu Arg Thr Leu Leu Asn Glu Thr 
        195                 200                 205             


Pro Glu Gln Ile Lys Tyr Ile Leu Ala Gln Tyr Asn Thr Thr Lys Asp 
    210                 215                 220                 


Lys Ala Phe Thr Asp Leu Asn Ser Ile Asn Ser Val Leu Gly Gly Gly 
225                 230                 235                 240 


Ile Leu Asp Arg Leu Arg Pro Asn Ile Ile Pro Val Leu Asp Glu Ile 
                245                 250                 255     


Lys Ser Met Ala Thr Ala Ile Lys Glu Thr Lys Glu Ala Leu Glu Asn 
            260                 265                 270         


Met Asn Ser Thr Leu Lys Ser Leu His Gln Gln Ser Thr Gln Leu Ser 
        275                 280                 285             


Ser Ser Leu Thr Ser Val Lys Thr Ser Leu Arg Ser Ser Leu Asn Asp 
    290                 295                 300                 


Pro Leu Cys Leu Val His Pro Ser Ser Glu Thr Cys Asn Ser Ile Arg 
305                 310                 315                 320 


Leu Ser Leu Ser Gln Leu Asn Ser Asn Pro Glu Leu Arg Gln Leu Pro 
                325                 330                 335     


Pro Val Asp Ala Glu Leu Asp Asn Val Asn Asn Val Leu Arg Thr Asp 
            340                 345                 350         


Leu Asp Gly Leu Val Gln Gln Gly Tyr Gln Ser Leu Asn Asp Ile Pro 
        355                 360                 365             


Asp Arg Val Gln Arg Gln Thr Thr Thr Val Val Ala Gly Ile Lys Arg 
    370                 375                 380                 


Val Leu Asn Ser Ile Gly Ser Asp Ile Asp Asn Val Thr Gln Arg Leu 
385                 390                 395                 400 


Pro Ile Gln Asp Ile Leu Ser Ala Phe Ser Val Tyr Val Asn Asn Thr 
                405                 410                 415     


Glu Ser Tyr Ile His Arg Asn Leu Pro Thr Leu Glu Glu Tyr Asp Ser 
            420                 425                 430         


Tyr Trp Trp Leu Gly Gly Leu Val Ile Cys Ser Leu Leu Thr Leu Ile 
        435                 440                 445             


Val Ile Phe Tyr Tyr Leu Gly Leu Leu Cys Gly Val Cys Gly Tyr Asp 
    450                 455                 460                 


Arg His Ala Thr Pro Thr Thr Arg Gly Cys Val Ser Asn Thr Gly Gly 
465                 470                 475                 480 


Val Phe Leu Met Val Gly Val Gly Leu Ser Phe Leu Phe Cys Trp Ile 
                485                 490                 495     


Leu Met Ile Ile Val Val Leu Thr Phe Val Phe Gly Ala Asn Val Glu 
            500                 505                 510         


Lys Leu Ile Cys Glu Pro Tyr Thr Ser Lys Glu Leu Phe Arg Val Leu 
        515                 520                 525             


Asp Thr Pro Tyr Leu Leu Asn Glu Asp Trp Glu Tyr Tyr Leu Ser Gly 
    530                 535                 540                 


Lys Leu Phe Asn Lys Ser Lys Met Lys Leu Thr Phe Glu Gln Val Tyr 
545                 550                 555                 560 


Ser Asp Cys Lys Lys Asn Arg Gly Thr Tyr Gly Thr Leu His Leu Gln 
                565                 570                 575     


Asn Ser Phe Asn Ile Ser Glu His Leu Asn Ile Asn Glu His Thr Gly 
            580                 585                 590         


Ser Ile Ser Ser Glu Leu Glu Ser Leu Lys Val Asn Leu Asn Ile Phe 
        595                 600                 605             


Leu Leu Gly Ala Ala Gly Arg Lys Asn Leu Gln Asp Phe Ala Ala Cys 
    610                 615                 620                 


Gly Ile Asp Arg Met Asn Tyr Asp Ser Tyr Leu Ala Gln Thr Gly Lys 
625                 630                 635                 640 


Ser Pro Ala Gly Val Asn Leu Leu Ser Phe Ala Tyr Asp Leu Glu Ala 
                645                 650                 655     


Lys Ala Asn Ser Leu Pro Pro Gly Asn Leu Arg Asn Ser Leu Lys Arg 
            660                 665                 670         


Asp Ala Gln Thr Ile Lys Thr Ile His Gln Gln Arg Val Leu Pro Ile 
        675                 680                 685             


Glu Gln Ser Leu Ser Thr Leu Tyr Gln Ser Val Lys Ile Leu Gln Arg 
    690                 695                 700                 


Thr Gly Asn Gly Leu Leu Glu Arg Val Thr Arg Ile Leu Ala Ser Leu 
705                 710                 715                 720 


Asp Phe Ala Gln Asn Phe Ile Thr Asn Asn Thr Ser Ser Val Ile Ile 
                725                 730                 735     


Glu Glu Thr Lys Lys Tyr Gly Arg Thr Ile Ile Gly Tyr Phe Glu His 
            740                 745                 750         


Tyr Leu Gln Trp Ile Glu Phe Ser Ile Ser Glu Lys Val Ala Ser Cys 
        755                 760                 765             


Lys Pro Val Ala Thr Ala Leu Asp Thr Ala Val Asp Val Phe Leu Cys 
    770                 775                 780                 


Ser Tyr Ile Ile Asp Pro Leu Asn Leu Phe Trp Phe Gly Ile Gly Lys 
785                 790                 795                 800 


Ala Thr Val Phe Leu Leu Pro Ala Leu Ile Phe Ala Val Lys Leu Ala 
                805                 810                 815     


Lys Tyr Tyr Arg Arg Met Asp Ser Glu Asp Val Tyr Asp Asp Val Glu 
            820                 825                 830         


Thr Ile Pro Met Lys Asn Pro Ser Gln His 
        835                 840         


<210>  1881
<211>  834
<212>  PRT
<213>  Homo sapiens

<400>  1881

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15      


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30          


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45              


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60                  


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80  


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Pro Glu Thr Val 
                85                  90                  95      


Ile Leu Gly Leu Lys Ile Val Tyr Tyr Glu Ala Gly Ile Ile Leu Cys 
            100                 105                 110         


Cys Val Leu Gly Leu Leu Phe Ile Ile Leu Met Pro Leu Val Gly Tyr 
        115                 120                 125             


Phe Phe Cys Met Cys Arg Cys Cys Asn Lys Cys Gly Gly Glu Met His 
    130                 135                 140                 


Gln Arg Gln Lys Glu Asn Gly Pro Phe Leu Arg Lys Cys Phe Ala Ile 
145                 150                 155                 160 


Ser Leu Leu Val Ile Cys Ile Ile Ile Ser Ile Gly Ile Phe Tyr Gly 
                165                 170                 175     


Phe Val Ala Asn His Gln Val Arg Thr Arg Ile Lys Arg Ser Arg Lys 
            180                 185                 190         


Leu Ala Asp Ser Asn Phe Lys Asp Leu Arg Thr Leu Leu Asn Glu Thr 
        195                 200                 205             


Pro Glu Gln Ile Lys Tyr Ile Leu Ala Gln Tyr Asn Thr Thr Lys Asp 
    210                 215                 220                 


Lys Ala Phe Thr Asp Leu Asn Ser Ile Asn Ser Val Leu Gly Gly Gly 
225                 230                 235                 240 


Ile Leu Asp Arg Leu Arg Pro Asn Ile Ile Pro Val Leu Asp Glu Ile 
                245                 250                 255     


Lys Ser Met Ala Thr Ala Ile Lys Glu Thr Lys Glu Ala Leu Glu Asn 
            260                 265                 270         


Met Asn Ser Thr Leu Lys Ser Leu His Gln Gln Ser Thr Gln Leu Ser 
        275                 280                 285             


Ser Ser Leu Thr Ser Val Lys Thr Ser Leu Arg Ser Ser Leu Asn Asp 
    290                 295                 300                 


Pro Leu Cys Leu Val His Pro Ser Ser Glu Thr Cys Asn Ser Ile Arg 
305                 310                 315                 320 


Leu Ser Leu Ser Gln Leu Asn Ser Asn Pro Glu Leu Arg Gln Leu Pro 
                325                 330                 335     


Pro Val Asp Ala Glu Leu Asp Asn Val Asn Asn Val Leu Arg Thr Asp 
            340                 345                 350         


Leu Asp Gly Leu Val Gln Gln Gly Tyr Gln Ser Leu Asn Asp Ile Pro 
        355                 360                 365             


Asp Arg Val Gln Arg Gln Thr Thr Thr Val Val Ala Gly Ile Lys Arg 
    370                 375                 380                 


Val Leu Asn Ser Ile Gly Ser Asp Ile Asp Asn Val Thr Gln Arg Leu 
385                 390                 395                 400 


Pro Ile Gln Asp Ile Leu Ser Ala Phe Ser Val Tyr Val Asn Asn Thr 
                405                 410                 415     


Glu Ser Tyr Ile His Arg Asn Leu Pro Thr Leu Glu Glu Tyr Asp Ser 
            420                 425                 430         


Tyr Trp Trp Leu Gly Gly Leu Val Ile Cys Ser Leu Leu Thr Leu Ile 
        435                 440                 445             


Val Ile Phe Tyr Tyr Leu Gly Leu Leu Cys Gly Val Cys Gly Tyr Asp 
    450                 455                 460                 


Arg His Ala Thr Pro Thr Thr Arg Gly Cys Val Ser Asn Thr Gly Gly 
465                 470                 475                 480 


Val Phe Leu Met Val Gly Val Gly Leu Ser Phe Leu Phe Cys Trp Ile 
                485                 490                 495     


Leu Met Ile Ile Val Val Leu Thr Phe Val Phe Gly Ala Asn Val Glu 
            500                 505                 510         


Lys Leu Ile Cys Glu Pro Tyr Thr Ser Lys Glu Leu Phe Arg Val Leu 
        515                 520                 525             


Asp Thr Pro Tyr Leu Leu Asn Glu Asp Trp Glu Tyr Tyr Leu Ser Gly 
    530                 535                 540                 


Lys Leu Phe Asn Lys Ser Lys Met Lys Leu Thr Phe Glu Gln Val Tyr 
545                 550                 555                 560 


Ser Asp Cys Lys Lys Asn Arg Gly Thr Tyr Gly Thr Leu His Leu Gln 
                565                 570                 575     


Asn Ser Phe Asn Ile Ser Glu His Leu Asn Ile Asn Glu His Thr Gly 
            580                 585                 590         


Ser Ile Ser Ser Glu Leu Glu Ser Leu Lys Val Asn Leu Asn Ile Phe 
        595                 600                 605             


Leu Leu Gly Ala Ala Gly Arg Lys Asn Leu Gln Asp Phe Ala Ala Cys 
    610                 615                 620                 


Gly Ile Asp Arg Met Asn Tyr Asp Ser Tyr Leu Ala Gln Thr Gly Lys 
625                 630                 635                 640 


Ser Pro Ala Gly Val Asn Leu Leu Ser Phe Ala Tyr Asp Leu Glu Ala 
                645                 650                 655     


Lys Ala Asn Ser Leu Pro Pro Gly Asn Leu Arg Asn Ser Leu Lys Arg 
            660                 665                 670         


Asp Ala Gln Thr Ile Lys Thr Ile His Gln Gln Arg Val Leu Pro Ile 
        675                 680                 685             


Glu Gln Ser Leu Ser Thr Leu Tyr Gln Ser Val Lys Ile Leu Gln Arg 
    690                 695                 700                 


Thr Gly Asn Gly Leu Leu Glu Arg Val Thr Arg Ile Leu Ala Ser Leu 
705                 710                 715                 720 


Asp Phe Ala Gln Asn Phe Ile Thr Asn Asn Thr Ser Ser Val Ile Ile 
                725                 730                 735     


Glu Glu Thr Lys Lys Tyr Gly Arg Thr Ile Ile Gly Tyr Phe Glu His 
            740                 745                 750         


Tyr Leu Gln Trp Ile Glu Phe Ser Ile Ser Glu Lys Val Ala Ser Cys 
        755                 760                 765             


Lys Pro Val Ala Thr Ala Leu Asp Thr Ala Val Asp Val Phe Leu Cys 
    770                 775                 780                 


Ser Tyr Ile Ile Asp Pro Leu Asn Leu Phe Trp Phe Gly Ile Gly Lys 
785                 790                 795                 800 


Ala Thr Val Phe Leu Leu Pro Ala Leu Ile Phe Ala Val Lys Leu Ala 
                805                 810                 815     


Lys Tyr Tyr Arg Arg Met Asp Ser Glu Asp Val Tyr Asp Asp Pro Ser 
            820                 825                 830         


Gln His 
        


<210>  1882
<211>  833
<212>  PRT
<213>  Homo sapiens

<400>  1882

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15      


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30          


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45              


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60                  


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80  


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Ile Val Tyr Tyr 
                85                  90                  95      


Glu Ala Gly Ile Ile Leu Cys Cys Val Leu Gly Leu Leu Phe Ile Ile 
            100                 105                 110         


Leu Met Pro Leu Val Gly Tyr Phe Phe Cys Met Cys Arg Cys Cys Asn 
        115                 120                 125             


Lys Cys Gly Gly Glu Met His Gln Arg Gln Lys Glu Asn Gly Pro Phe 
    130                 135                 140                 


Leu Arg Lys Cys Phe Ala Ile Ser Leu Leu Val Ile Cys Ile Ile Ile 
145                 150                 155                 160 


Ser Ile Gly Ile Phe Tyr Gly Phe Val Ala Asn His Gln Val Arg Thr 
                165                 170                 175     


Arg Ile Lys Arg Ser Arg Lys Leu Ala Asp Ser Asn Phe Lys Asp Leu 
            180                 185                 190         


Arg Thr Leu Leu Asn Glu Thr Pro Glu Gln Ile Lys Tyr Ile Leu Ala 
        195                 200                 205             


Gln Tyr Asn Thr Thr Lys Asp Lys Ala Phe Thr Asp Leu Asn Ser Ile 
    210                 215                 220                 


Asn Ser Val Leu Gly Gly Gly Ile Leu Asp Arg Leu Arg Pro Asn Ile 
225                 230                 235                 240 


Ile Pro Val Leu Asp Glu Ile Lys Ser Met Ala Thr Ala Ile Lys Glu 
                245                 250                 255     


Thr Lys Glu Ala Leu Glu Asn Met Asn Ser Thr Leu Lys Ser Leu His 
            260                 265                 270         


Gln Gln Ser Thr Gln Leu Ser Ser Ser Leu Thr Ser Val Lys Thr Ser 
        275                 280                 285             


Leu Arg Ser Ser Leu Asn Asp Pro Leu Cys Leu Val His Pro Ser Ser 
    290                 295                 300                 


Glu Thr Cys Asn Ser Ile Arg Leu Ser Leu Ser Gln Leu Asn Ser Asn 
305                 310                 315                 320 


Pro Glu Leu Arg Gln Leu Pro Pro Val Asp Ala Glu Leu Asp Asn Val 
                325                 330                 335     


Asn Asn Val Leu Arg Thr Asp Leu Asp Gly Leu Val Gln Gln Gly Tyr 
            340                 345                 350         


Gln Ser Leu Asn Asp Ile Pro Asp Arg Val Gln Arg Gln Thr Thr Thr 
        355                 360                 365             


Val Val Ala Gly Ile Lys Arg Val Leu Asn Ser Ile Gly Ser Asp Ile 
    370                 375                 380                 


Asp Asn Val Thr Gln Arg Leu Pro Ile Gln Asp Ile Leu Ser Ala Phe 
385                 390                 395                 400 


Ser Val Tyr Val Asn Asn Thr Glu Ser Tyr Ile His Arg Asn Leu Pro 
                405                 410                 415     


Thr Leu Glu Glu Tyr Asp Ser Tyr Trp Trp Leu Gly Gly Leu Val Ile 
            420                 425                 430         


Cys Ser Leu Leu Thr Leu Ile Val Ile Phe Tyr Tyr Leu Gly Leu Leu 
        435                 440                 445             


Cys Gly Val Cys Gly Tyr Asp Arg His Ala Thr Pro Thr Thr Arg Gly 
    450                 455                 460                 


Cys Val Ser Asn Thr Gly Gly Val Phe Leu Met Val Gly Val Gly Leu 
465                 470                 475                 480 


Ser Phe Leu Phe Cys Trp Ile Leu Met Ile Ile Val Val Leu Thr Phe 
                485                 490                 495     


Val Phe Gly Ala Asn Val Glu Lys Leu Ile Cys Glu Pro Tyr Thr Ser 
            500                 505                 510         


Lys Glu Leu Phe Arg Val Leu Asp Thr Pro Tyr Leu Leu Asn Glu Asp 
        515                 520                 525             


Trp Glu Tyr Tyr Leu Ser Gly Lys Leu Phe Asn Lys Ser Lys Met Lys 
    530                 535                 540                 


Leu Thr Phe Glu Gln Val Tyr Ser Asp Cys Lys Lys Asn Arg Gly Thr 
545                 550                 555                 560 


Tyr Gly Thr Leu His Leu Gln Asn Ser Phe Asn Ile Ser Glu His Leu 
                565                 570                 575     


Asn Ile Asn Glu His Thr Gly Ser Ile Ser Ser Glu Leu Glu Ser Leu 
            580                 585                 590         


Lys Val Asn Leu Asn Ile Phe Leu Leu Gly Ala Ala Gly Arg Lys Asn 
        595                 600                 605             


Leu Gln Asp Phe Ala Ala Cys Gly Ile Asp Arg Met Asn Tyr Asp Ser 
    610                 615                 620                 


Tyr Leu Ala Gln Thr Gly Lys Ser Pro Ala Gly Val Asn Leu Leu Ser 
625                 630                 635                 640 


Phe Ala Tyr Asp Leu Glu Ala Lys Ala Asn Ser Leu Pro Pro Gly Asn 
                645                 650                 655     


Leu Arg Asn Ser Leu Lys Arg Asp Ala Gln Thr Ile Lys Thr Ile His 
            660                 665                 670         


Gln Gln Arg Val Leu Pro Ile Glu Gln Ser Leu Ser Thr Leu Tyr Gln 
        675                 680                 685             


Ser Val Lys Ile Leu Gln Arg Thr Gly Asn Gly Leu Leu Glu Arg Val 
    690                 695                 700                 


Thr Arg Ile Leu Ala Ser Leu Asp Phe Ala Gln Asn Phe Ile Thr Asn 
705                 710                 715                 720 


Asn Thr Ser Ser Val Ile Ile Glu Glu Thr Lys Lys Tyr Gly Arg Thr 
                725                 730                 735     


Ile Ile Gly Tyr Phe Glu His Tyr Leu Gln Trp Ile Glu Phe Ser Ile 
            740                 745                 750         


Ser Glu Lys Val Ala Ser Cys Lys Pro Val Ala Thr Ala Leu Asp Thr 
        755                 760                 765             


Ala Val Asp Val Phe Leu Cys Ser Tyr Ile Ile Asp Pro Leu Asn Leu 
    770                 775                 780                 


Phe Trp Phe Gly Ile Gly Lys Ala Thr Val Phe Leu Leu Pro Ala Leu 
785                 790                 795                 800 


Ile Phe Ala Val Lys Leu Ala Lys Tyr Tyr Arg Arg Met Asp Ser Glu 
                805                 810                 815     


Asp Val Tyr Asp Asp Val Glu Thr Ile Pro Met Lys Asn Pro Ser Gln 
            820                 825                 830         


His 
    


<210>  1883
<211>  825
<212>  PRT
<213>  Homo sapiens

<400>  1883

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15      


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30          


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45              


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60                  


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80  


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Ile Val Tyr Tyr 
                85                  90                  95      


Glu Ala Gly Ile Ile Leu Cys Cys Val Leu Gly Leu Leu Phe Ile Ile 
            100                 105                 110         


Leu Met Pro Leu Val Gly Tyr Phe Phe Cys Met Cys Arg Cys Cys Asn 
        115                 120                 125             


Lys Cys Gly Gly Glu Met His Gln Arg Gln Lys Glu Asn Gly Pro Phe 
    130                 135                 140                 


Leu Arg Lys Cys Phe Ala Ile Ser Leu Leu Val Ile Cys Ile Ile Ile 
145                 150                 155                 160 


Ser Ile Gly Ile Phe Tyr Gly Phe Val Ala Asn His Gln Val Arg Thr 
                165                 170                 175     


Arg Ile Lys Arg Ser Arg Lys Leu Ala Asp Ser Asn Phe Lys Asp Leu 
            180                 185                 190         


Arg Thr Leu Leu Asn Glu Thr Pro Glu Gln Ile Lys Tyr Ile Leu Ala 
        195                 200                 205             


Gln Tyr Asn Thr Thr Lys Asp Lys Ala Phe Thr Asp Leu Asn Ser Ile 
    210                 215                 220                 


Asn Ser Val Leu Gly Gly Gly Ile Leu Asp Arg Leu Arg Pro Asn Ile 
225                 230                 235                 240 


Ile Pro Val Leu Asp Glu Ile Lys Ser Met Ala Thr Ala Ile Lys Glu 
                245                 250                 255     


Thr Lys Glu Ala Leu Glu Asn Met Asn Ser Thr Leu Lys Ser Leu His 
            260                 265                 270         


Gln Gln Ser Thr Gln Leu Ser Ser Ser Leu Thr Ser Val Lys Thr Ser 
        275                 280                 285             


Leu Arg Ser Ser Leu Asn Asp Pro Leu Cys Leu Val His Pro Ser Ser 
    290                 295                 300                 


Glu Thr Cys Asn Ser Ile Arg Leu Ser Leu Ser Gln Leu Asn Ser Asn 
305                 310                 315                 320 


Pro Glu Leu Arg Gln Leu Pro Pro Val Asp Ala Glu Leu Asp Asn Val 
                325                 330                 335     


Asn Asn Val Leu Arg Thr Asp Leu Asp Gly Leu Val Gln Gln Gly Tyr 
            340                 345                 350         


Gln Ser Leu Asn Asp Ile Pro Asp Arg Val Gln Arg Gln Thr Thr Thr 
        355                 360                 365             


Val Val Ala Gly Ile Lys Arg Val Leu Asn Ser Ile Gly Ser Asp Ile 
    370                 375                 380                 


Asp Asn Val Thr Gln Arg Leu Pro Ile Gln Asp Ile Leu Ser Ala Phe 
385                 390                 395                 400 


Ser Val Tyr Val Asn Asn Thr Glu Ser Tyr Ile His Arg Asn Leu Pro 
                405                 410                 415     


Thr Leu Glu Glu Tyr Asp Ser Tyr Trp Trp Leu Gly Gly Leu Val Ile 
            420                 425                 430         


Cys Ser Leu Leu Thr Leu Ile Val Ile Phe Tyr Tyr Leu Gly Leu Leu 
        435                 440                 445             


Cys Gly Val Cys Gly Tyr Asp Arg His Ala Thr Pro Thr Thr Arg Gly 
    450                 455                 460                 


Cys Val Ser Asn Thr Gly Gly Val Phe Leu Met Val Gly Val Gly Leu 
465                 470                 475                 480 


Ser Phe Leu Phe Cys Trp Ile Leu Met Ile Ile Val Val Leu Thr Phe 
                485                 490                 495     


Val Phe Gly Ala Asn Val Glu Lys Leu Ile Cys Glu Pro Tyr Thr Ser 
            500                 505                 510         


Lys Glu Leu Phe Arg Val Leu Asp Thr Pro Tyr Leu Leu Asn Glu Asp 
        515                 520                 525             


Trp Glu Tyr Tyr Leu Ser Gly Lys Leu Phe Asn Lys Ser Lys Met Lys 
    530                 535                 540                 


Leu Thr Phe Glu Gln Val Tyr Ser Asp Cys Lys Lys Asn Arg Gly Thr 
545                 550                 555                 560 


Tyr Gly Thr Leu His Leu Gln Asn Ser Phe Asn Ile Ser Glu His Leu 
                565                 570                 575     


Asn Ile Asn Glu His Thr Gly Ser Ile Ser Ser Glu Leu Glu Ser Leu 
            580                 585                 590         


Lys Val Asn Leu Asn Ile Phe Leu Leu Gly Ala Ala Gly Arg Lys Asn 
        595                 600                 605             


Leu Gln Asp Phe Ala Ala Cys Gly Ile Asp Arg Met Asn Tyr Asp Ser 
    610                 615                 620                 


Tyr Leu Ala Gln Thr Gly Lys Ser Pro Ala Gly Val Asn Leu Leu Ser 
625                 630                 635                 640 


Phe Ala Tyr Asp Leu Glu Ala Lys Ala Asn Ser Leu Pro Pro Gly Asn 
                645                 650                 655     


Leu Arg Asn Ser Leu Lys Arg Asp Ala Gln Thr Ile Lys Thr Ile His 
            660                 665                 670         


Gln Gln Arg Val Leu Pro Ile Glu Gln Ser Leu Ser Thr Leu Tyr Gln 
        675                 680                 685             


Ser Val Lys Ile Leu Gln Arg Thr Gly Asn Gly Leu Leu Glu Arg Val 
    690                 695                 700                 


Thr Arg Ile Leu Ala Ser Leu Asp Phe Ala Gln Asn Phe Ile Thr Asn 
705                 710                 715                 720 


Asn Thr Ser Ser Val Ile Ile Glu Glu Thr Lys Lys Tyr Gly Arg Thr 
                725                 730                 735     


Ile Ile Gly Tyr Phe Glu His Tyr Leu Gln Trp Ile Glu Phe Ser Ile 
            740                 745                 750         


Ser Glu Lys Val Ala Ser Cys Lys Pro Val Ala Thr Ala Leu Asp Thr 
        755                 760                 765             


Ala Val Asp Val Phe Leu Cys Ser Tyr Ile Ile Asp Pro Leu Asn Leu 
    770                 775                 780                 


Phe Trp Phe Gly Ile Gly Lys Ala Thr Val Phe Leu Leu Pro Ala Leu 
785                 790                 795                 800 


Ile Phe Ala Val Lys Leu Ala Lys Tyr Tyr Arg Arg Met Asp Ser Glu 
                805                 810                 815     


Asp Val Tyr Asp Asp Pro Ser Gln His 
            820                 825 


<210>  1884
<211>  890
<212>  PRT
<213>  Homo sapiens

<400>  1884

Met Asp Ser Asn Thr Ala Pro Leu Gly Pro Ser Cys Pro Gln Pro Pro 
1               5                   10                  15      


Pro Ala Pro Gln Pro Gln Ala Arg Ser Arg Leu Asn Ala Thr Ala Ser 
            20                  25                  30          


Leu Glu Gln Glu Arg Ser Glu Arg Pro Arg Ala Pro Gly Pro Gln Ala 
        35                  40                  45              


Gly Pro Gly Pro Gly Val Arg Asp Ala Ala Ala Pro Ala Glu Pro Gln 
    50                  55                  60                  


Ala Gln His Thr Arg Ser Arg Glu Arg Ala Asp Gly Thr Gly Pro Thr 
65                  70                  75                  80  


Lys Gly Asp Met Glu Ile Pro Phe Glu Glu Val Leu Glu Arg Ala Lys 
                85                  90                  95      


Ala Gly Asp Pro Lys Ala Gln Thr Glu Val Gly Lys His Tyr Leu Gln 
            100                 105                 110         


Leu Ala Gly Asp Thr Asp Glu Glu Leu Asn Ser Cys Thr Ala Val Asp 
        115                 120                 125             


Trp Leu Val Leu Ala Ala Lys Gln Gly Arg Arg Glu Ala Val Lys Leu 
    130                 135                 140                 


Leu Arg Arg Cys Leu Ala Asp Arg Arg Gly Ile Thr Ser Glu Asn Glu 
145                 150                 155                 160 


Arg Glu Val Arg Gln Leu Ser Ser Glu Thr Asp Leu Glu Arg Ala Val 
                165                 170                 175     


Arg Lys Ala Ala Leu Val Met Tyr Trp Lys Leu Asn Pro Lys Lys Lys 
            180                 185                 190         


Lys Gln Val Ala Val Ala Glu Leu Leu Glu Asn Val Gly Gln Val Asn 
        195                 200                 205             


Glu His Asp Gly Gly Ala Gln Pro Gly Pro Val Pro Lys Ser Leu Gln 
    210                 215                 220                 


Lys Gln Arg Arg Met Leu Glu Arg Leu Val Ser Ser Glu Ser Lys Asn 
225                 230                 235                 240 


Tyr Ile Ala Leu Asp Asp Phe Val Glu Ile Thr Lys Lys Tyr Ala Lys 
                245                 250                 255     


Gly Val Ile Pro Ser Ser Leu Phe Leu Gln Asp Asp Glu Asp Asp Asp 
            260                 265                 270         


Glu Leu Ala Gly Lys Ser Pro Glu Asp Leu Pro Leu Arg Leu Lys Val 
        275                 280                 285             


Val Lys Tyr Pro Leu His Ala Ile Met Glu Ile Lys Glu Tyr Leu Ile 
    290                 295                 300                 


Asp Met Ala Ser Arg Ala Gly Met His Trp Leu Ser Thr Ile Ile Pro 
305                 310                 315                 320 


Thr His His Ile Asn Ala Leu Ile Phe Phe Phe Ile Val Ser Asn Leu 
                325                 330                 335     


Thr Ile Asp Phe Phe Ala Phe Phe Ile Pro Leu Val Ile Phe Tyr Leu 
            340                 345                 350         


Ser Phe Ile Ser Met Val Ile Cys Thr Leu Lys Val Phe Gln Asp Ser 
        355                 360                 365             


Lys Ala Trp Glu Asn Phe Arg Thr Leu Thr Asp Leu Leu Leu Arg Phe 
    370                 375                 380                 


Glu Pro Asn Leu Asp Val Glu Gln Ala Glu Val Asn Phe Gly Trp Asn 
385                 390                 395                 400 


His Leu Glu Pro Tyr Ala His Phe Leu Leu Ser Val Phe Phe Val Ile 
                405                 410                 415     


Phe Ser Phe Pro Ile Ala Ser Lys Asp Cys Ile Pro Cys Ser Glu Leu 
            420                 425                 430         


Ala Val Ile Thr Gly Phe Phe Thr Val Thr Ser Tyr Leu Ser Leu Ser 
        435                 440                 445             


Thr His Ala Glu Pro Tyr Thr Arg Arg Ala Leu Ala Thr Glu Val Thr 
    450                 455                 460                 


Ala Gly Leu Leu Ser Leu Leu Pro Ser Met Pro Leu Asn Trp Pro Tyr 
465                 470                 475                 480 


Leu Lys Val Leu Gly Gln Thr Phe Ile Thr Val Pro Val Gly His Leu 
                485                 490                 495     


Val Val Leu Asn Val Ser Val Pro Cys Leu Leu Tyr Val Tyr Leu Leu 
            500                 505                 510         


Tyr Leu Phe Phe Arg Met Ala Gln Leu Arg Asn Phe Lys Gly Thr Tyr 
        515                 520                 525             


Cys Tyr Leu Val Pro Tyr Leu Val Cys Phe Met Trp Cys Glu Leu Ser 
    530                 535                 540                 


Val Val Ile Leu Leu Glu Ser Thr Gly Leu Gly Leu Leu Arg Ala Ser 
545                 550                 555                 560 


Ile Gly Tyr Phe Leu Phe Leu Phe Ala Leu Pro Ile Leu Val Ala Gly 
                565                 570                 575     


Leu Ala Leu Val Gly Val Leu Gln Phe Ala Arg Trp Phe Thr Ser Leu 
            580                 585                 590         


Glu Leu Thr Lys Ile Ala Val Thr Val Ala Val Cys Ser Val Pro Leu 
        595                 600                 605             


Leu Leu Arg Trp Trp Thr Lys Ala Ser Phe Ser Val Val Gly Met Val 
    610                 615                 620                 


Lys Ser Leu Thr Arg Ser Ser Met Val Lys Leu Ile Leu Val Trp Leu 
625                 630                 635                 640 


Thr Ala Ile Val Leu Phe Cys Trp Phe Tyr Val Tyr Arg Ser Glu Gly 
                645                 650                 655     


Met Lys Val Tyr Asn Ser Thr Leu Thr Trp Gln Gln Tyr Gly Ala Leu 
            660                 665                 670         


Cys Gly Pro Arg Ala Trp Lys Glu Thr Asn Met Ala Arg Thr Gln Ile 
        675                 680                 685             


Leu Cys Ser His Leu Glu Gly His Arg Val Thr Trp Thr Gly Arg Phe 
    690                 695                 700                 


Lys Tyr Val Arg Val Thr Asp Ile Asp Asn Ser Ala Glu Ser Ala Ile 
705                 710                 715                 720 


Asn Met Leu Pro Phe Phe Ile Gly Asp Trp Met Arg Cys Leu Tyr Gly 
                725                 730                 735     


Glu Ala Tyr Pro Ala Cys Ser Pro Gly Asn Thr Ser Thr Ala Glu Glu 
            740                 745                 750         


Glu Leu Cys Arg Leu Lys Leu Leu Ala Lys His Pro Cys His Ile Lys 
        755                 760                 765             


Lys Phe Asp Arg Tyr Lys Phe Glu Ile Thr Val Gly Met Pro Phe Ser 
    770                 775                 780                 


Ser Gly Ala Asp Gly Ser Arg Ser Arg Glu Glu Asp Asp Val Thr Lys 
785                 790                 795                 800 


Asp Ile Val Leu Arg Ala Ser Ser Glu Phe Lys Ser Val Leu Leu Ser 
                805                 810                 815     


Leu Arg Gln Gly Ser Leu Ile Glu Phe Ser Thr Ile Leu Glu Gly Arg 
            820                 825                 830         


Leu Gly Ser Lys Trp Pro Val Phe Glu Leu Lys Ala Ile Ser Cys Leu 
        835                 840                 845             


Asn Cys Met Ala Gln Leu Ser Pro Thr Arg Arg His Val Lys Ile Glu 
    850                 855                 860                 


His Asp Trp Arg Ser Thr Val His Gly Ala Val Lys Phe Ala Phe Asp 
865                 870                 875                 880 


Phe Phe Phe Phe Pro Phe Leu Ser Ala Ala 
                885                 890 


<210>  1885
<211>  612
<212>  PRT
<213>  Homo sapiens

<400>  1885

Met Gly Val Gly Thr Leu Leu Ile Ala Met Pro Gln Phe Phe Met Glu 
1               5                   10                  15      


Gln Tyr Lys Tyr Glu Arg Tyr Ser Pro Ser Ser Asn Ser Thr Leu Ser 
            20                  25                  30          


Ile Ser Pro Cys Leu Leu Glu Ser Ser Ser Gln Leu Pro Val Ser Val 
        35                  40                  45              


Met Glu Lys Ser Lys Ser Lys Ile Ser Asn Glu Cys Glu Val Asp Thr 
    50                  55                  60                  


Ser Ser Ser Met Trp Ile Tyr Val Phe Leu Gly Asn Leu Leu Arg Gly 
65                  70                  75                  80  


Ile Gly Glu Thr Pro Ile Gln Pro Leu Gly Ile Ala Tyr Leu Asp Asp 
                85                  90                  95      


Phe Ala Ser Glu Asp Asn Ala Ala Phe Tyr Ile Gly Cys Val Gln Thr 
            100                 105                 110         


Val Ala Ile Ile Gly Pro Ile Phe Gly Phe Leu Leu Gly Ser Leu Cys 
        115                 120                 125             


Ala Lys Leu Tyr Val Asp Ile Gly Phe Val Asn Leu Asp His Ile Thr 
    130                 135                 140                 


Ile Thr Pro Lys Asp Pro Gln Trp Val Gly Ala Trp Trp Leu Gly Tyr 
145                 150                 155                 160 


Leu Ile Ala Gly Ile Ile Ser Leu Leu Ala Ala Val Pro Phe Trp Tyr 
                165                 170                 175     


Leu Pro Lys Ser Leu Pro Arg Ser Gln Ser Arg Glu Asp Ser Asn Ser 
            180                 185                 190         


Ser Ser Glu Lys Ser Lys Phe Ile Ile Asp Asp His Thr Asp Tyr Gln 
        195                 200                 205             


Thr Pro Gln Gly Glu Asn Ala Lys Ile Met Glu Met Ala Arg Asp Phe 
    210                 215                 220                 


Leu Pro Ser Leu Lys Asn Leu Phe Gly Asn Pro Val Tyr Phe Leu Tyr 
225                 230                 235                 240 


Leu Cys Thr Ser Thr Val Gln Phe Asn Ser Leu Phe Gly Met Val Thr 
                245                 250                 255     


Tyr Lys Pro Lys Tyr Ile Glu Gln Gln Tyr Gly Gln Ser Ser Ser Arg 
            260                 265                 270         


Ala Asn Phe Val Ile Gly Leu Ile Asn Ile Pro Ala Val Ala Leu Gly 
        275                 280                 285             


Ile Phe Ser Gly Gly Ile Val Met Lys Lys Phe Arg Ile Ser Val Cys 
    290                 295                 300                 


Gly Ala Ala Lys Leu Tyr Leu Gly Ser Ser Val Phe Gly Tyr Leu Leu 
305                 310                 315                 320 


Phe Leu Ser Leu Phe Ala Leu Gly Cys Glu Asn Ser Asp Val Ala Gly 
                325                 330                 335     


Leu Thr Val Ser Tyr Gln Gly Thr Lys Pro Val Ser Tyr His Glu Arg 
            340                 345                 350         


Ala Leu Phe Ser Asp Cys Asn Ser Arg Cys Lys Cys Ser Glu Thr Lys 
        355                 360                 365             


Trp Glu Pro Met Cys Gly Glu Asn Gly Ile Thr Tyr Val Ser Ala Cys 
    370                 375                 380                 


Leu Ala Gly Cys Gln Thr Ser Asn Arg Ser Gly Lys Asn Ile Ile Phe 
385                 390                 395                 400 


Tyr Asn Cys Thr Cys Val Gly Ile Ala Ala Ser Lys Ser Gly Asn Ser 
                405                 410                 415     


Ser Gly Ile Val Gly Arg Cys Gln Lys Asp Asn Gly Cys Pro Gln Met 
            420                 425                 430         


Phe Leu Tyr Phe Leu Val Ile Ser Val Ile Thr Ser Tyr Thr Leu Ser 
        435                 440                 445             


Leu Gly Gly Ile Pro Gly Tyr Ile Leu Leu Leu Arg Cys Ile Lys Pro 
    450                 455                 460                 


Gln Leu Lys Ser Phe Ala Leu Gly Ile Tyr Thr Leu Ala Ile Arg Val 
465                 470                 475                 480 


Leu Ala Gly Ile Pro Ala Pro Val Tyr Phe Gly Val Leu Ile Asp Thr 
                485                 490                 495     


Ser Cys Leu Lys Trp Gly Phe Lys Arg Cys Gly Ser Arg Gly Ser Cys 
            500                 505                 510         


Arg Leu Tyr Asp Ser Asn Val Phe Arg Tyr Gln Ile Lys Ser Ile Pro 
        515                 520                 525             


Ala Ser His Cys Tyr Ser Ile Pro Asp Leu His Asn Ala Thr Asp Thr 
    530                 535                 540                 


Asn Lys Phe Ser Cys His Phe Thr Ala Cys Lys Thr Tyr Ile Ser Gly 
545                 550                 555                 560 


Thr Asn Cys Asp Thr Gly His Ser Val Asn Ser Pro Lys His Cys Ser 
                565                 570                 575     


Thr Phe His Phe Lys Glu Lys Leu Cys Phe Lys Thr Gln Lys Phe Tyr 
            580                 585                 590         


Asn Gln Glu Arg Lys Asn Asn Gly Val Tyr Lys Ile Pro Lys Gly Lys 
        595                 600                 605             


Leu His Tyr Lys 
    610         


<210>  1886
<211>  663
<212>  PRT
<213>  Homo sapiens

<400>  1886

Met Asp Thr Ser Ser Lys Glu Asn Ile Gln Leu Phe Cys Lys Thr Ser 
1               5                   10                  15      


Val Gln Pro Val Gly Arg Pro Ser Phe Lys Thr Glu Tyr Pro Ser Ser 
            20                  25                  30          


Glu Glu Lys Gln Pro Cys Cys Gly Glu Leu Lys Val Phe Leu Cys Ala 
        35                  40                  45              


Leu Ser Phe Val Tyr Phe Ala Lys Ala Leu Ala Glu Gly Tyr Leu Lys 
    50                  55                  60                  


Ser Thr Ile Thr Gln Ile Glu Arg Arg Phe Asp Ile Pro Ser Ser Leu 
65                  70                  75                  80  


Val Gly Val Ile Asp Gly Ser Phe Glu Ile Gly Asn Leu Leu Val Ile 
                85                  90                  95      


Thr Phe Val Ser Tyr Phe Gly Ala Lys Leu His Arg Pro Lys Ile Ile 
            100                 105                 110         


Gly Ala Gly Cys Val Ile Met Gly Val Gly Thr Leu Leu Ile Ala Met 
        115                 120                 125             


Pro Gln Phe Phe Met Glu Gln Tyr Lys Tyr Glu Arg Tyr Ser Pro Ser 
    130                 135                 140                 


Ser Asn Ser Thr Leu Ser Ile Ser Pro Cys Leu Leu Glu Ser Ser Ser 
145                 150                 155                 160 


Gln Leu Pro Val Ser Val Met Glu Lys Ser Lys Ser Lys Ile Ser Asn 
                165                 170                 175     


Gly Cys Val Gln Thr Val Ala Ile Ile Gly Pro Ile Phe Gly Phe Leu 
            180                 185                 190         


Leu Gly Ser Leu Cys Ala Lys Leu Tyr Val Asp Ile Gly Phe Val Asn 
        195                 200                 205             


Leu Asp His Ile Thr Ile Thr Pro Lys Asp Pro Gln Trp Val Gly Ala 
    210                 215                 220                 


Trp Trp Leu Gly Tyr Leu Ile Ala Gly Ile Ile Ser Leu Leu Ala Ala 
225                 230                 235                 240 


Val Pro Phe Trp Tyr Leu Pro Lys Ser Leu Pro Arg Ser Gln Ser Arg 
                245                 250                 255     


Glu Asp Ser Asn Ser Ser Ser Glu Lys Ser Lys Phe Ile Ile Asp Asp 
            260                 265                 270         


His Thr Asp Tyr Gln Thr Pro Gln Gly Glu Asn Ala Lys Ile Met Glu 
        275                 280                 285             


Met Ala Arg Asp Phe Leu Pro Ser Leu Lys Asn Leu Phe Gly Asn Pro 
    290                 295                 300                 


Val Tyr Phe Leu Tyr Leu Cys Thr Ser Thr Val Gln Phe Asn Ser Leu 
305                 310                 315                 320 


Phe Gly Met Val Thr Tyr Lys Pro Lys Tyr Ile Glu Gln Gln Tyr Gly 
                325                 330                 335     


Gln Ser Ser Ser Arg Ala Asn Phe Val Ile Gly Leu Ile Asn Ile Pro 
            340                 345                 350         


Ala Val Ala Leu Gly Ile Phe Ser Gly Gly Ile Val Met Lys Lys Phe 
        355                 360                 365             


Arg Ile Ser Val Cys Gly Ala Ala Lys Leu Tyr Leu Gly Ser Ser Val 
    370                 375                 380                 


Phe Gly Tyr Leu Leu Phe Leu Ser Leu Phe Ala Leu Gly Cys Glu Asn 
385                 390                 395                 400 


Ser Asp Val Ala Gly Leu Thr Val Ser Tyr Gln Gly Thr Lys Pro Val 
                405                 410                 415     


Ser Tyr His Glu Arg Ala Leu Phe Ser Asp Cys Asn Ser Arg Cys Lys 
            420                 425                 430         


Cys Ser Glu Thr Lys Trp Glu Pro Met Cys Gly Glu Asn Gly Ile Thr 
        435                 440                 445             


Tyr Val Ser Ala Cys Leu Ala Gly Cys Gln Thr Ser Asn Arg Ser Gly 
    450                 455                 460                 


Lys Asn Ile Ile Phe Tyr Asn Cys Thr Cys Val Gly Ile Ala Ala Ser 
465                 470                 475                 480 


Lys Ser Gly Asn Ser Ser Gly Ile Val Gly Arg Cys Gln Lys Asp Asn 
                485                 490                 495     


Gly Cys Pro Gln Met Phe Leu Tyr Phe Leu Val Ile Ser Val Ile Thr 
            500                 505                 510         


Ser Tyr Thr Leu Ser Leu Gly Gly Ile Pro Gly Tyr Ile Leu Leu Leu 
        515                 520                 525             


Arg Cys Ile Lys Pro Gln Leu Lys Ser Phe Ala Leu Gly Ile Tyr Thr 
    530                 535                 540                 


Leu Ala Ile Arg Val Leu Ala Gly Ile Pro Ala Pro Val Tyr Phe Gly 
545                 550                 555                 560 


Val Leu Ile Asp Thr Ser Cys Leu Lys Trp Gly Phe Lys Arg Cys Gly 
                565                 570                 575     


Ser Arg Gly Ser Cys Arg Leu Tyr Asp Ser Asn Val Phe Arg His Ile 
            580                 585                 590         


Tyr Leu Gly Leu Thr Val Ile Leu Gly Thr Val Ser Ile Leu Leu Ser 
        595                 600                 605             


Ile Ala Val Leu Phe Ile Leu Lys Lys Asn Tyr Val Ser Lys His Arg 
    610                 615                 620                 


Ser Phe Ile Thr Lys Arg Glu Arg Thr Met Val Ser Thr Arg Phe Gln 
625                 630                 635                 640 


Lys Glu Asn Tyr Thr Thr Ser Asp His Leu Leu Gln Pro Asn Tyr Trp 
                645                 650                 655     


Pro Gly Lys Glu Thr Gln Leu 
            660             


<210>  1887
<211>  730
<212>  PRT
<213>  Homo sapiens

<400>  1887

Met Asp Thr Ser Ser Lys Glu Asn Ile Gln Leu Phe Cys Lys Thr Ser 
1               5                   10                  15      


Val Gln Pro Val Gly Arg Pro Ser Phe Lys Thr Glu Tyr Pro Ser Ser 
            20                  25                  30          


Glu Glu Lys Gln Pro Cys Cys Gly Glu Leu Lys Val Phe Leu Cys Ala 
        35                  40                  45              


Leu Ser Phe Val Tyr Phe Ala Lys Ala Leu Ala Glu Gly Tyr Leu Lys 
    50                  55                  60                  


Ser Thr Ile Thr Gln Ile Glu Arg Arg Phe Asp Ile Pro Ser Ser Leu 
65                  70                  75                  80  


Val Gly Val Ile Asp Gly Ser Phe Glu Ile Gly Asn Leu Leu Val Ile 
                85                  90                  95      


Thr Phe Val Ser Tyr Phe Gly Ala Lys Leu His Arg Pro Lys Ile Ile 
            100                 105                 110         


Gly Ala Gly Cys Val Ile Met Gly Val Gly Thr Leu Leu Ile Ala Met 
        115                 120                 125             


Pro Gln Phe Phe Met Glu Gln Tyr Lys Tyr Glu Arg Tyr Ser Pro Ser 
    130                 135                 140                 


Ser Asn Ser Thr Leu Ser Ile Ser Pro Cys Leu Leu Glu Ser Ser Ser 
145                 150                 155                 160 


Gln Leu Pro Val Ser Val Met Glu Lys Ser Lys Ser Lys Ile Ser Asn 
                165                 170                 175     


Glu Cys Glu Val Asp Thr Ser Ser Ser Met Trp Ile Tyr Val Phe Leu 
            180                 185                 190         


Gly Asn Leu Leu Arg Gly Ile Gly Glu Thr Pro Ile Gln Pro Leu Gly 
        195                 200                 205             


Ile Ala Tyr Leu Asp Asp Phe Ala Ser Glu Asp Asn Ala Ala Phe Tyr 
    210                 215                 220                 


Ile Gly Cys Val Gln Thr Val Ala Ile Ile Gly Pro Ile Phe Gly Phe 
225                 230                 235                 240 


Leu Leu Gly Ser Leu Cys Ala Lys Leu Tyr Val Asp Ile Gly Phe Val 
                245                 250                 255     


Asn Leu Asp His Ile Thr Ile Thr Pro Lys Asp Pro Gln Trp Val Gly 
            260                 265                 270         


Ala Trp Trp Leu Gly Tyr Leu Ile Ala Gly Ile Ile Ser Leu Leu Ala 
        275                 280                 285             


Ala Val Pro Phe Trp Tyr Leu Pro Lys Ser Leu Pro Arg Ser Gln Ser 
    290                 295                 300                 


Arg Glu Asp Ser Asn Ser Ser Ser Glu Lys Ser Lys Phe Ile Ile Asp 
305                 310                 315                 320 


Asp His Thr Asp Tyr Gln Thr Pro Gln Gly Glu Asn Ala Lys Ile Met 
                325                 330                 335     


Glu Met Ala Arg Asp Phe Leu Pro Ser Leu Lys Asn Leu Phe Gly Asn 
            340                 345                 350         


Pro Val Tyr Phe Leu Tyr Leu Cys Thr Ser Thr Val Gln Phe Asn Ser 
        355                 360                 365             


Leu Phe Gly Met Val Thr Tyr Lys Pro Lys Tyr Ile Glu Gln Gln Tyr 
    370                 375                 380                 


Gly Gln Ser Ser Ser Arg Ala Asn Phe Val Ile Gly Leu Ile Asn Ile 
385                 390                 395                 400 


Pro Ala Val Ala Leu Gly Ile Phe Ser Gly Gly Ile Val Met Lys Lys 
                405                 410                 415     


Phe Arg Ile Ser Val Cys Gly Ala Ala Lys Leu Tyr Leu Gly Ser Ser 
            420                 425                 430         


Val Phe Gly Tyr Leu Leu Phe Leu Ser Leu Phe Ala Leu Gly Cys Glu 
        435                 440                 445             


Asn Ser Asp Val Ala Gly Leu Thr Val Ser Tyr Gln Gly Thr Lys Pro 
    450                 455                 460                 


Val Ser Tyr His Glu Arg Ala Leu Phe Ser Asp Cys Asn Ser Arg Cys 
465                 470                 475                 480 


Lys Cys Ser Glu Thr Lys Trp Glu Pro Met Cys Gly Glu Asn Gly Ile 
                485                 490                 495     


Thr Tyr Val Ser Ala Cys Leu Ala Gly Cys Gln Thr Ser Asn Arg Ser 
            500                 505                 510         


Gly Lys Asn Ile Ile Phe Tyr Asn Cys Thr Cys Val Gly Ile Ala Ala 
        515                 520                 525             


Ser Lys Ser Gly Asn Ser Ser Gly Ile Val Gly Arg Cys Gln Lys Asp 
    530                 535                 540                 


Asn Gly Cys Pro Gln Met Phe Leu Tyr Phe Leu Val Ile Ser Val Ile 
545                 550                 555                 560 


Thr Ser Tyr Thr Leu Ser Leu Gly Gly Ile Pro Gly Tyr Ile Leu Leu 
                565                 570                 575     


Leu Arg Cys Ile Lys Pro Gln Leu Lys Ser Phe Ala Leu Gly Ile Tyr 
            580                 585                 590         


Thr Leu Ala Ile Arg Val Leu Ala Gly Ile Pro Ala Pro Val Tyr Phe 
        595                 600                 605             


Gly Val Leu Ile Asp Thr Ser Cys Leu Lys Trp Gly Phe Lys Arg Cys 
    610                 615                 620                 


Gly Ser Arg Gly Ser Cys Arg Leu Tyr Asp Ser Asn Val Phe Arg Tyr 
625                 630                 635                 640 


Gln Ile Lys Ser Ile Pro Ala Ser His Cys Tyr Ser Ile Pro Asp Leu 
                645                 650                 655     


His Asn Ala Thr Asp Thr Asn Lys Phe Ser Cys His Phe Thr Ala Cys 
            660                 665                 670         


Lys Thr Tyr Ile Ser Gly Thr Asn Cys Asp Thr Gly His Ser Val Asn 
        675                 680                 685             


Ser Pro Lys His Cys Ser Thr Phe His Phe Lys Glu Lys Leu Cys Phe 
    690                 695                 700                 


Lys Thr Gln Lys Phe Tyr Asn Gln Glu Arg Lys Asn Asn Gly Val Tyr 
705                 710                 715                 720 


Lys Ile Pro Lys Gly Lys Leu His Tyr Lys 
                725                 730 


<210>  1888
<211>  1079
<212>  PRT
<213>  Homo sapiens

<400>  1888

Met Pro His Phe Thr Val Val Pro Val Asp Gly Pro Arg Arg Gly Asp 
1               5                   10                  15      


Tyr Asp Asn Leu Glu Gly Leu Ser Trp Val Asp Tyr Gly Glu Arg Ala 
            20                  25                  30          


Glu Leu Asp Asp Ser Asp Gly His Gly Asn His Arg Glu Ser Ser Pro 
        35                  40                  45              


Phe Leu Ser Pro Leu Glu Ala Ser Arg Gly Ile Asp Tyr Tyr Asp Arg 
    50                  55                  60                  


Asn Leu Ala Leu Phe Glu Glu Glu Leu Asp Ile Arg Pro Lys Val Ser 
65                  70                  75                  80  


Ser Leu Leu Gly Lys Leu Val Ser Tyr Thr Asn Leu Thr Gln Gly Ala 
                85                  90                  95      


Lys Glu His Glu Glu Ala Glu Ser Gly Glu Gly Thr Arg Arg Arg Ala 
            100                 105                 110         


Ala Glu Ala Pro Ser Met Gly Thr Leu Met Gly Val Tyr Leu Pro Cys 
        115                 120                 125             


Leu Gln Asn Ile Phe Gly Val Ile Leu Phe Leu Arg Leu Thr Trp Met 
    130                 135                 140                 


Val Gly Thr Ala Gly Val Leu Gln Ala Leu Leu Ile Val Leu Ile Cys 
145                 150                 155                 160 


Cys Cys Cys Thr Leu Leu Thr Ala Ile Ser Met Ser Ala Ile Ala Thr 
                165                 170                 175     


Asn Gly Val Val Pro Ala Gly Gly Ser Tyr Phe Met Ile Ser Arg Ser 
            180                 185                 190         


Leu Gly Pro Glu Phe Gly Gly Ala Val Gly Leu Cys Phe Tyr Leu Gly 
        195                 200                 205             


Thr Thr Phe Ala Ala Ala Met Tyr Ile Leu Gly Ala Ile Glu Ile Leu 
    210                 215                 220                 


Leu Thr Tyr Ile Ala Pro Pro Ala Ala Ile Phe Tyr Pro Ser Gly Ala 
225                 230                 235                 240 


His Asp Thr Ser Asn Ala Thr Leu Asn Asn Met Arg Val Tyr Gly Thr 
                245                 250                 255     


Ile Phe Leu Thr Phe Met Thr Leu Val Val Phe Val Gly Val Lys Tyr 
            260                 265                 270         


Val Asn Lys Phe Ala Ser Leu Phe Leu Ala Cys Val Ile Ile Ser Ile 
        275                 280                 285             


Leu Ser Ile Tyr Ala Gly Gly Ile Lys Ser Ile Phe Asp Pro Pro Val 
    290                 295                 300                 


Phe Pro Val Cys Met Leu Gly Asn Arg Thr Leu Ser Arg Asp Gln Phe 
305                 310                 315                 320 


Asp Ile Cys Ala Lys Thr Ala Val Val Asp Asn Glu Thr Val Ala Thr 
                325                 330                 335     


Gln Leu Trp Ser Phe Phe Cys His Ser Pro Asn Leu Thr Thr Asp Ser 
            340                 345                 350         


Cys Asp Pro Tyr Phe Met Leu Asn Asn Val Thr Glu Ile Pro Gly Ile 
        355                 360                 365             


Pro Gly Ala Ala Ala Gly Val Leu Gln Glu Asn Leu Trp Ser Ala Tyr 
    370                 375                 380                 


Leu Glu Lys Gly Asp Ile Val Glu Lys His Gly Leu Pro Ser Ala Asp 
385                 390                 395                 400 


Ala Pro Ser Leu Lys Glu Ser Leu Pro Leu Tyr Val Val Ala Asp Ile 
                405                 410                 415     


Ala Thr Ser Phe Thr Val Leu Val Gly Ile Phe Phe Pro Ser Val Thr 
            420                 425                 430         


Gly Ile Met Ala Gly Ser Asn Arg Ser Gly Asp Leu Arg Asp Ala Gln 
        435                 440                 445             


Lys Ser Ile Pro Val Gly Thr Ile Leu Ala Ile Ile Thr Thr Ser Leu 
    450                 455                 460                 


Val Tyr Phe Ser Ser Val Val Leu Phe Gly Ala Cys Ile Glu Gly Val 
465                 470                 475                 480 


Val Leu Arg Asp Lys Tyr Gly Asp Gly Val Ser Arg Asn Leu Val Val 
                485                 490                 495     


Gly Thr Leu Ala Trp Pro Ser Pro Trp Val Ile Val Ile Gly Ser Phe 
            500                 505                 510         


Phe Ser Thr Cys Gly Ala Gly Leu Gln Ser Leu Thr Gly Ala Pro Arg 
        515                 520                 525             


Leu Leu Gln Ala Ile Ala Lys Asp Asn Ile Ile Pro Phe Leu Arg Val 
    530                 535                 540                 


Phe Gly His Gly Lys Val Asn Gly Glu Pro Thr Trp Ala Leu Leu Leu 
545                 550                 555                 560 


Thr Ala Leu Ile Ala Glu Leu Gly Ile Leu Ile Ala Ser Leu Asp Met 
                565                 570                 575     


Val Ala Pro Ile Leu Ser Met Phe Phe Leu Met Cys Tyr Leu Phe Val 
            580                 585                 590         


Asn Leu Ala Cys Ala Val Gln Thr Leu Leu Arg Thr Pro Asn Trp Arg 
        595                 600                 605             


Pro Arg Phe Lys Tyr Tyr His Trp Ala Leu Ser Phe Leu Gly Met Ser 
    610                 615                 620                 


Leu Cys Leu Ala Leu Met Phe Val Ser Ser Trp Tyr Tyr Ala Leu Val 
625                 630                 635                 640 


Ala Met Leu Ile Ala Gly Met Ile Tyr Lys Tyr Ile Glu Tyr Gln Gly 
                645                 650                 655     


Ala Glu Lys Glu Trp Gly Asp Gly Ile Arg Gly Leu Ser Leu Ser Ala 
            660                 665                 670         


Ala Arg Tyr Ala Leu Leu Arg Leu Glu Glu Gly Pro Pro His Thr Lys 
        675                 680                 685             


Asn Trp Arg Pro Gln Leu Leu Val Leu Leu Lys Leu Asp Glu Asp Leu 
    690                 695                 700                 


His Val Lys Tyr Pro Arg Leu Leu Thr Phe Ala Ser Gln Leu Lys Ala 
705                 710                 715                 720 


Gly Lys Gly Leu Thr Ile Val Gly Ser Val Ile Gln Gly Ser Phe Leu 
                725                 730                 735     


Glu Ser Tyr Gly Glu Ala Gln Ala Ala Glu Gln Thr Ile Lys Asn Met 
            740                 745                 750         


Met Glu Ile Glu Lys Val Lys Gly Phe Cys Gln Val Val Val Ala Ser 
        755                 760                 765             


Lys Val Arg Glu Gly Leu Ala His Leu Ile Gln Ser Cys Gly Leu Gly 
    770                 775                 780                 


Gly Met Arg His Asn Ser Val Val Leu Gly Trp Pro Tyr Gly Trp Arg 
785                 790                 795                 800 


Gln Ser Glu Asp Pro Arg Ala Trp Lys Thr Phe Ile Asp Thr Val Arg 
                805                 810                 815     


Cys Thr Thr Ala Ala His Leu Ala Leu Leu Val Pro Lys Asn Ile Ala 
            820                 825                 830         


Phe Tyr Pro Ser Asn His Glu Arg Tyr Leu Glu Gly His Ile Asp Val 
        835                 840                 845             


Trp Trp Ile Val His Asp Gly Gly Met Leu Met Leu Leu Pro Phe Leu 
    850                 855                 860                 


Leu Arg Gln His Lys Val Trp Arg Lys Cys Arg Met Arg Ile Phe Thr 
865                 870                 875                 880 


Val Ala Gln Met Asp Asp Asn Ser Ile Gln Met Lys Lys Asp Leu Ala 
                885                 890                 895     


Val Phe Leu Tyr His Leu Arg Leu Glu Ala Glu His Asn Ser Asp Ile 
            900                 905                 910         


Ser Ala Tyr Thr Tyr Glu Arg Thr Leu Met Met Glu Gln Arg Ser Gln 
        915                 920                 925             


Met Leu Arg Gln Met Arg Leu Thr Lys Thr Glu Arg Glu Arg Glu Ala 
    930                 935                 940                 


Gln Leu Val Lys Asp Arg His Ser Ala Leu Arg Leu Glu Ser Leu Tyr 
945                 950                 955                 960 


Ser Asp Glu Glu Asp Glu Ser Ala Val Gly Ala Asp Lys Ile Gln Met 
                965                 970                 975     


Thr Trp Thr Arg Asp Lys Tyr Met Thr Glu Thr Trp Asp Pro Ser His 
            980                 985                 990         


Ala Pro Asp Asn Phe Arg Glu Leu  Val His Ile Lys Pro  Asp Gln Ser 
        995                 1000                 1005             


Asn Val  Arg Arg Met His Thr  Ala Val Lys Leu Asn  Glu Val Ile 
    1010                 1015                 1020             


Val Thr  Arg Ser His Asp Ala  Arg Leu Val Leu Leu  Asn Met Pro 
    1025                 1030                 1035             


Gly Pro  Pro Arg Asn Ser Glu  Gly Asp Glu Asn Tyr  Met Glu Phe 
    1040                 1045                 1050             


Leu Glu  Val Leu Thr Glu Gly  Leu Glu Arg Val Leu  Leu Val Arg 
    1055                 1060                 1065             


Gly Gly  Gly Arg Glu Val Ile  Thr Ile Tyr Ser 
    1070                 1075                 


<210>  1889
<211>  1087
<212>  PRT
<213>  Homo sapiens

<400>  1889

Met Arg Ala Gly Gly Ala Cys Arg Pro Gly Ala Ala Gly Thr Ala Ala 
1               5                   10                  15      


Gly Thr Ala Ala Gly Gly Trp Asp Gly Gly Cys Gly Gly Ala Glu Pro 
            20                  25                  30          


Ala Arg Cys Leu Thr Ser Pro Trp Cys Gln Trp Thr Gly Arg Gly Ala 
        35                  40                  45              


Ala Thr Met Thr Thr Ser Arg Gly Ser Val Gly Trp Thr Thr Gly Ser 
    50                  55                  60                  


Ala Pro Ser Trp Met Thr Arg Thr Glu Glu Leu Asp Ile Arg Pro Lys 
65                  70                  75                  80  


Val Ser Ser Leu Leu Gly Lys Leu Val Ser Tyr Thr Asn Leu Thr Gln 
                85                  90                  95      


Gly Ala Lys Glu His Glu Glu Ala Glu Ser Gly Glu Gly Thr Arg Arg 
            100                 105                 110         


Arg Ala Ala Glu Ala Pro Ser Met Gly Thr Leu Met Gly Val Tyr Leu 
        115                 120                 125             


Pro Cys Leu Gln Asn Ile Phe Gly Val Ile Leu Phe Leu Arg Leu Thr 
    130                 135                 140                 


Trp Met Val Gly Thr Ala Gly Val Leu Gln Ala Leu Leu Ile Val Leu 
145                 150                 155                 160 


Ile Cys Cys Cys Cys Thr Leu Leu Thr Ala Ile Ser Met Ser Ala Ile 
                165                 170                 175     


Ala Thr Asn Gly Val Val Pro Ala Gly Gly Ser Tyr Phe Met Ile Ser 
            180                 185                 190         


Arg Ser Leu Gly Pro Glu Phe Gly Gly Ala Val Gly Leu Cys Phe Tyr 
        195                 200                 205             


Leu Gly Thr Thr Phe Ala Ala Ala Met Tyr Ile Leu Gly Ala Ile Glu 
    210                 215                 220                 


Ile Leu Leu Thr Tyr Ile Ala Pro Pro Ala Ala Ile Phe Tyr Pro Ser 
225                 230                 235                 240 


Gly Ala His Asp Thr Ser Asn Ala Thr Leu Asn Asn Met Arg Val Tyr 
                245                 250                 255     


Gly Thr Ile Phe Leu Thr Phe Met Thr Leu Val Val Phe Val Gly Val 
            260                 265                 270         


Lys Tyr Val Asn Lys Phe Ala Ser Leu Phe Leu Ala Cys Val Ile Ile 
        275                 280                 285             


Ser Ile Leu Ser Ile Tyr Ala Gly Gly Ile Lys Ser Ile Phe Asp Pro 
    290                 295                 300                 


Pro Val Phe Pro Val Cys Met Leu Gly Asn Arg Thr Leu Ser Arg Asp 
305                 310                 315                 320 


Gln Phe Asp Ile Cys Ala Lys Thr Ala Val Val Asp Asn Glu Thr Val 
                325                 330                 335     


Ala Thr Gln Leu Trp Ser Phe Phe Cys His Ser Pro Asn Leu Thr Thr 
            340                 345                 350         


Asp Ser Cys Asp Pro Tyr Phe Met Leu Asn Asn Val Thr Glu Ile Pro 
        355                 360                 365             


Gly Ile Pro Gly Ala Ala Ala Gly Val Leu Gln Glu Asn Leu Trp Ser 
    370                 375                 380                 


Ala Tyr Leu Glu Lys Gly Asp Ile Val Glu Lys His Gly Leu Pro Ser 
385                 390                 395                 400 


Ala Asp Ala Pro Ser Leu Lys Glu Ser Leu Pro Leu Tyr Val Val Ala 
                405                 410                 415     


Asp Ile Ala Thr Ser Phe Thr Val Leu Val Gly Ile Phe Phe Pro Ser 
            420                 425                 430         


Val Thr Gly Ile Met Ala Gly Ser Asn Arg Ser Gly Asp Leu Arg Asp 
        435                 440                 445             


Ala Gln Lys Ser Ile Pro Val Gly Thr Ile Leu Ala Ile Ile Thr Thr 
    450                 455                 460                 


Ser Leu Val Tyr Phe Ser Ser Val Val Leu Phe Gly Ala Cys Ile Glu 
465                 470                 475                 480 


Gly Val Val Leu Arg Asp Lys Tyr Gly Asp Gly Val Ser Arg Asn Leu 
                485                 490                 495     


Val Val Gly Thr Leu Ala Trp Pro Ser Pro Trp Val Ile Val Ile Gly 
            500                 505                 510         


Ser Phe Phe Ser Thr Cys Gly Ala Gly Leu Gln Ser Leu Thr Gly Ala 
        515                 520                 525             


Pro Arg Leu Leu Gln Ala Ile Ala Lys Asp Asn Ile Ile Pro Phe Leu 
    530                 535                 540                 


Arg Val Phe Gly His Gly Lys Val Asn Gly Glu Pro Thr Trp Ala Leu 
545                 550                 555                 560 


Leu Leu Thr Ala Leu Ile Ala Glu Leu Gly Ile Leu Ile Ala Ser Leu 
                565                 570                 575     


Asp Met Val Ala Pro Ile Leu Ser Met Phe Phe Leu Met Cys Tyr Leu 
            580                 585                 590         


Phe Val Asn Leu Ala Cys Ala Val Gln Thr Leu Leu Arg Thr Pro Asn 
        595                 600                 605             


Trp Arg Pro Arg Phe Lys Tyr Tyr His Trp Ala Leu Ser Phe Leu Gly 
    610                 615                 620                 


Met Ser Leu Cys Leu Ala Leu Met Phe Val Ser Ser Trp Tyr Tyr Ala 
625                 630                 635                 640 


Leu Val Ala Met Leu Ile Ala Gly Met Ile Tyr Lys Tyr Ile Glu Tyr 
                645                 650                 655     


Gln Gly Ala Glu Lys Glu Trp Gly Asp Gly Ile Arg Gly Leu Ser Leu 
            660                 665                 670         


Ser Ala Ala Arg Tyr Ala Leu Leu Arg Leu Glu Glu Gly Pro Pro His 
        675                 680                 685             


Thr Lys Asn Trp Arg Pro Gln Leu Leu Val Leu Leu Lys Leu Asp Glu 
    690                 695                 700                 


Asp Leu His Val Lys Tyr Pro Arg Leu Leu Thr Phe Ala Ser Gln Leu 
705                 710                 715                 720 


Lys Ala Gly Lys Gly Leu Thr Ile Val Gly Ser Val Ile Gln Gly Ser 
                725                 730                 735     


Phe Leu Glu Ser Tyr Gly Glu Ala Gln Ala Ala Glu Gln Thr Ile Lys 
            740                 745                 750         


Asn Met Met Glu Ile Glu Lys Val Lys Gly Phe Cys Gln Val Val Val 
        755                 760                 765             


Ala Ser Lys Val Arg Glu Gly Leu Ala His Leu Ile Gln Ser Cys Gly 
    770                 775                 780                 


Leu Gly Gly Met Arg His Asn Ser Val Val Leu Gly Trp Pro Tyr Gly 
785                 790                 795                 800 


Trp Arg Gln Ser Glu Asp Pro Arg Ala Trp Lys Thr Phe Ile Asp Thr 
                805                 810                 815     


Val Arg Cys Thr Thr Ala Ala His Leu Ala Leu Leu Val Pro Lys Asn 
            820                 825                 830         


Ile Ala Phe Tyr Pro Ser Asn His Glu Arg Tyr Leu Glu Gly His Ile 
        835                 840                 845             


Asp Val Trp Trp Ile Val His Asp Gly Gly Met Leu Met Leu Leu Pro 
    850                 855                 860                 


Phe Leu Leu Arg Gln His Lys Val Trp Arg Lys Cys Arg Met Arg Ile 
865                 870                 875                 880 


Phe Thr Val Ala Gln Met Asp Asp Asn Ser Ile Gln Met Lys Lys Asp 
                885                 890                 895     


Leu Ala Val Phe Leu Tyr His Leu Arg Leu Glu Ala Glu Val Glu Val 
            900                 905                 910         


Val Glu Met His Asn Ser Asp Ile Ser Ala Tyr Thr Tyr Glu Arg Thr 
        915                 920                 925             


Leu Met Met Glu Gln Arg Ser Gln Met Leu Arg Gln Met Arg Leu Thr 
    930                 935                 940                 


Lys Thr Glu Arg Glu Arg Glu Ala Gln Leu Val Lys Asp Arg His Ser 
945                 950                 955                 960 


Ala Leu Arg Leu Glu Ser Leu Tyr Ser Asp Glu Glu Asp Glu Ser Ala 
                965                 970                 975     


Val Gly Ala Asp Lys Ile Gln Met Thr Trp Thr Arg Asp Lys Tyr Met 
            980                 985                 990         


Thr Glu Thr Trp Asp Pro Ser His  Ala Pro Asp Asn Phe  Arg Glu Leu 
        995                 1000                 1005             


Val His  Ile Lys Pro Asp Gln  Ser Asn Val Arg Arg  Met His Thr 
    1010                 1015                 1020             


Ala Val  Lys Leu Asn Glu Val  Ile Val Thr Arg Ser  His Asp Ala 
    1025                 1030                 1035             


Arg Leu  Val Leu Leu Asn Met  Pro Gly Pro Pro Arg  Asn Ser Glu 
    1040                 1045                 1050             


Gly Asp  Glu Asn Tyr Met Glu  Phe Leu Glu Val Leu  Thr Glu Gly 
    1055                 1060                 1065             


Leu Glu  Arg Val Leu Leu Val  Arg Gly Gly Gly Arg  Glu Val Ile 
    1070                 1075                 1080             


Thr Ile  Tyr Ser 
    1085         


<210>  1890
<211>  1079
<212>  PRT
<213>  Homo sapiens

<400>  1890

Met Ala Ala Glu Gly Ala Val Cys Gly Phe Val Tyr Leu Glu Gly Thr 
1               5                   10                  15      


Ala Trp Ala Val Pro Glu Asp Thr Glu Pro Leu Ala Ser Cys Thr Leu 
            20                  25                  30          


Gly His Gly Asn His Arg Glu Ser Ser Pro Phe Leu Ser Pro Leu Glu 
        35                  40                  45              


Ala Ser Arg Gly Ile Asp Tyr Tyr Asp Arg Asn Leu Ala Leu Phe Glu 
    50                  55                  60                  


Glu Glu Leu Asp Ile Arg Pro Lys Val Ser Ser Leu Leu Gly Lys Leu 
65                  70                  75                  80  


Val Ser Tyr Thr Asn Leu Thr Gln Gly Ala Lys Glu His Glu Glu Ala 
                85                  90                  95      


Glu Ser Gly Glu Gly Thr Arg Arg Arg Ala Ala Glu Ala Pro Ser Met 
            100                 105                 110         


Gly Thr Leu Met Gly Val Tyr Leu Pro Cys Leu Gln Asn Ile Phe Gly 
        115                 120                 125             


Val Ile Leu Phe Leu Arg Leu Thr Trp Met Val Gly Thr Ala Gly Val 
    130                 135                 140                 


Leu Gln Ala Leu Leu Ile Val Leu Ile Cys Cys Cys Cys Thr Leu Leu 
145                 150                 155                 160 


Thr Ala Ile Ser Met Ser Ala Ile Ala Thr Asn Gly Val Val Pro Ala 
                165                 170                 175     


Gly Gly Ser Tyr Phe Met Ile Ser Arg Ser Leu Gly Pro Glu Phe Gly 
            180                 185                 190         


Gly Ala Val Gly Leu Cys Phe Tyr Leu Gly Thr Thr Phe Ala Ala Ala 
        195                 200                 205             


Met Tyr Ile Leu Gly Ala Ile Glu Ile Leu Leu Thr Tyr Ile Ala Pro 
    210                 215                 220                 


Pro Ala Ala Ile Phe Tyr Pro Ser Gly Ala His Asp Thr Ser Asn Ala 
225                 230                 235                 240 


Thr Leu Asn Asn Met Arg Val Tyr Gly Thr Ile Phe Leu Thr Phe Met 
                245                 250                 255     


Thr Leu Val Val Phe Val Gly Val Lys Tyr Val Asn Lys Phe Ala Ser 
            260                 265                 270         


Leu Phe Leu Ala Cys Val Ile Ile Ser Ile Leu Ser Ile Tyr Ala Gly 
        275                 280                 285             


Gly Ile Lys Ser Ile Phe Asp Pro Pro Val Phe Pro Val Cys Met Leu 
    290                 295                 300                 


Gly Asn Arg Thr Leu Ser Arg Asp Gln Phe Asp Ile Cys Ala Lys Thr 
305                 310                 315                 320 


Ala Val Val Asp Asn Glu Thr Val Ala Thr Gln Leu Trp Ser Phe Phe 
                325                 330                 335     


Cys His Ser Pro Asn Leu Thr Thr Asp Ser Cys Asp Pro Tyr Phe Met 
            340                 345                 350         


Leu Asn Asn Val Thr Glu Ile Pro Gly Ile Pro Gly Ala Ala Ala Gly 
        355                 360                 365             


Val Leu Gln Glu Asn Leu Trp Ser Ala Tyr Leu Glu Lys Gly Asp Ile 
    370                 375                 380                 


Val Glu Lys His Gly Leu Pro Ser Ala Asp Ala Pro Ser Leu Lys Glu 
385                 390                 395                 400 


Ser Leu Pro Leu Tyr Val Val Ala Asp Ile Ala Thr Ser Phe Thr Val 
                405                 410                 415     


Leu Val Gly Ile Phe Phe Pro Ser Val Thr Gly Ile Met Ala Gly Ser 
            420                 425                 430         


Asn Arg Ser Gly Asp Leu Arg Asp Ala Gln Lys Ser Ile Pro Val Gly 
        435                 440                 445             


Thr Ile Leu Ala Ile Ile Thr Thr Ser Leu Val Tyr Phe Ser Ser Val 
    450                 455                 460                 


Val Leu Phe Gly Ala Cys Ile Glu Gly Val Val Leu Arg Asp Lys Tyr 
465                 470                 475                 480 


Gly Asp Gly Val Ser Arg Asn Leu Val Val Gly Thr Leu Ala Trp Pro 
                485                 490                 495     


Ser Pro Trp Val Ile Val Ile Gly Ser Phe Phe Ser Thr Cys Gly Ala 
            500                 505                 510         


Gly Leu Gln Ser Leu Thr Gly Ala Pro Arg Leu Leu Gln Ala Ile Ala 
        515                 520                 525             


Lys Asp Asn Ile Ile Pro Phe Leu Arg Val Phe Gly His Gly Lys Val 
    530                 535                 540                 


Asn Gly Glu Pro Thr Trp Ala Leu Leu Leu Thr Ala Leu Ile Ala Glu 
545                 550                 555                 560 


Leu Gly Ile Leu Ile Ala Ser Leu Asp Met Val Ala Pro Ile Leu Ser 
                565                 570                 575     


Met Phe Phe Leu Met Cys Tyr Leu Phe Val Asn Leu Ala Cys Ala Val 
            580                 585                 590         


Gln Thr Leu Leu Arg Thr Pro Asn Trp Arg Pro Arg Phe Lys Tyr Tyr 
        595                 600                 605             


His Trp Ala Leu Ser Phe Leu Gly Met Ser Leu Cys Leu Ala Leu Met 
    610                 615                 620                 


Phe Val Ser Ser Trp Tyr Tyr Ala Leu Val Ala Met Leu Ile Ala Gly 
625                 630                 635                 640 


Met Ile Tyr Lys Tyr Ile Glu Tyr Gln Gly Ala Glu Lys Glu Trp Gly 
                645                 650                 655     


Asp Gly Ile Arg Gly Leu Ser Leu Ser Ala Ala Arg Tyr Ala Leu Leu 
            660                 665                 670         


Arg Leu Glu Glu Gly Pro Pro His Thr Lys Asn Trp Arg Pro Gln Leu 
        675                 680                 685             


Leu Val Leu Leu Lys Leu Asp Glu Asp Leu His Val Lys Tyr Pro Arg 
    690                 695                 700                 


Leu Leu Thr Phe Ala Ser Gln Leu Lys Ala Gly Lys Gly Leu Thr Ile 
705                 710                 715                 720 


Val Gly Ser Val Ile Gln Gly Ser Phe Leu Glu Ser Tyr Gly Glu Ala 
                725                 730                 735     


Gln Ala Ala Glu Gln Thr Ile Lys Asn Met Met Glu Ile Glu Lys Val 
            740                 745                 750         


Lys Gly Phe Cys Gln Val Val Val Ala Ser Lys Val Arg Glu Gly Leu 
        755                 760                 765             


Ala His Leu Ile Gln Ser Cys Gly Leu Gly Gly Met Arg His Asn Ser 
    770                 775                 780                 


Val Val Leu Gly Trp Pro Tyr Gly Trp Arg Gln Ser Glu Asp Pro Arg 
785                 790                 795                 800 


Ala Trp Lys Thr Phe Ile Asp Thr Val Arg Cys Thr Thr Ala Ala His 
                805                 810                 815     


Leu Ala Leu Leu Val Pro Lys Asn Ile Ala Phe Tyr Pro Ser Asn His 
            820                 825                 830         


Glu Arg Tyr Leu Glu Gly His Ile Asp Val Trp Trp Ile Val His Asp 
        835                 840                 845             


Gly Gly Met Leu Met Leu Leu Pro Phe Leu Leu Arg Gln His Lys Val 
    850                 855                 860                 


Trp Arg Lys Cys Arg Met Arg Ile Phe Thr Val Ala Gln Met Asp Asp 
865                 870                 875                 880 


Asn Ser Ile Gln Met Lys Lys Asp Leu Ala Val Phe Leu Tyr His Leu 
                885                 890                 895     


Arg Leu Glu Ala Glu Val Glu Val Val Glu Met His Asn Ser Asp Ile 
            900                 905                 910         


Ser Ala Tyr Thr Tyr Glu Arg Thr Leu Met Met Glu Gln Arg Ser Gln 
        915                 920                 925             


Met Leu Arg Gln Met Arg Leu Thr Lys Thr Glu Arg Glu Arg Glu Ala 
    930                 935                 940                 


Gln Leu Val Lys Asp Arg His Ser Ala Leu Arg Leu Glu Ser Leu Tyr 
945                 950                 955                 960 


Ser Asp Glu Glu Asp Glu Ser Ala Val Gly Ala Asp Lys Ile Gln Met 
                965                 970                 975     


Thr Trp Thr Arg Asp Lys Tyr Met Thr Glu Thr Trp Asp Pro Ser His 
            980                 985                 990         


Ala Pro Asp Asn Phe Arg Glu Leu  Val His Ile Lys Pro  Asp Gln Ser 
        995                 1000                 1005             


Asn Val  Arg Arg Met His Thr  Ala Val Lys Leu Asn  Glu Val Ile 
    1010                 1015                 1020             


Val Thr  Arg Ser His Asp Ala  Arg Leu Val Leu Leu  Asn Met Pro 
    1025                 1030                 1035             


Gly Pro  Pro Arg Asn Ser Glu  Gly Asp Glu Asn Tyr  Met Glu Phe 
    1040                 1045                 1050             


Leu Glu  Val Leu Thr Glu Gly  Leu Glu Arg Val Leu  Leu Val Arg 
    1055                 1060                 1065             


Gly Gly  Gly Arg Glu Val Ile  Thr Ile Tyr Ser 
    1070                 1075                 


<210>  1891
<211>  1054
<212>  PRT
<213>  Homo sapiens

<400>  1891

Met Gly Asp Thr Leu Ser Pro Gly His Gly Asn His Arg Glu Ser Ser 
1               5                   10                  15      


Pro Phe Leu Ser Pro Leu Glu Ala Ser Arg Gly Ile Asp Tyr Tyr Asp 
            20                  25                  30          


Arg Asn Leu Ala Leu Phe Glu Glu Glu Leu Asp Ile Arg Pro Lys Val 
        35                  40                  45              


Ser Ser Leu Leu Gly Lys Leu Val Ser Tyr Thr Asn Leu Thr Gln Gly 
    50                  55                  60                  


Ala Lys Glu His Glu Glu Ala Glu Ser Gly Glu Gly Thr Arg Arg Arg 
65                  70                  75                  80  


Ala Ala Glu Ala Pro Ser Met Gly Thr Leu Met Gly Val Tyr Leu Pro 
                85                  90                  95      


Cys Leu Gln Asn Ile Phe Gly Val Ile Leu Phe Leu Arg Leu Thr Trp 
            100                 105                 110         


Met Val Gly Thr Ala Gly Val Leu Gln Ala Leu Leu Ile Val Leu Ile 
        115                 120                 125             


Cys Cys Cys Cys Thr Leu Leu Thr Ala Ile Ser Met Ser Ala Ile Ala 
    130                 135                 140                 


Thr Asn Gly Val Val Pro Ala Gly Gly Ser Tyr Phe Met Ile Ser Arg 
145                 150                 155                 160 


Ser Leu Gly Pro Glu Phe Gly Gly Ala Val Gly Leu Cys Phe Tyr Leu 
                165                 170                 175     


Gly Thr Thr Phe Ala Ala Ala Met Tyr Ile Leu Gly Ala Ile Glu Ile 
            180                 185                 190         


Leu Leu Thr Tyr Ile Ala Pro Pro Ala Ala Ile Phe Tyr Pro Ser Gly 
        195                 200                 205             


Ala His Asp Thr Ser Asn Ala Thr Leu Asn Asn Met Arg Val Tyr Gly 
    210                 215                 220                 


Thr Ile Phe Leu Thr Phe Met Thr Leu Val Val Phe Val Gly Val Lys 
225                 230                 235                 240 


Tyr Val Asn Lys Phe Ala Ser Leu Phe Leu Ala Cys Val Ile Ile Ser 
                245                 250                 255     


Ile Leu Ser Ile Tyr Ala Gly Gly Ile Lys Ser Ile Phe Asp Pro Pro 
            260                 265                 270         


Val Phe Pro Val Cys Met Leu Gly Asn Arg Thr Leu Ser Arg Asp Gln 
        275                 280                 285             


Phe Asp Ile Cys Ala Lys Thr Ala Val Val Asp Asn Glu Thr Val Ala 
    290                 295                 300                 


Thr Gln Leu Trp Ser Phe Phe Cys His Ser Pro Asn Leu Thr Thr Asp 
305                 310                 315                 320 


Ser Cys Asp Pro Tyr Phe Met Leu Asn Asn Val Thr Glu Ile Pro Gly 
                325                 330                 335     


Ile Pro Gly Ala Ala Ala Gly Val Leu Gln Glu Asn Leu Trp Ser Ala 
            340                 345                 350         


Tyr Leu Glu Lys Gly Asp Ile Val Glu Lys His Gly Leu Pro Ser Ala 
        355                 360                 365             


Asp Ala Pro Ser Leu Lys Glu Ser Leu Pro Leu Tyr Val Val Ala Asp 
    370                 375                 380                 


Ile Ala Thr Ser Phe Thr Val Leu Val Gly Ile Phe Phe Pro Ser Val 
385                 390                 395                 400 


Thr Gly Ile Met Ala Gly Ser Asn Arg Ser Gly Asp Leu Arg Asp Ala 
                405                 410                 415     


Gln Lys Ser Ile Pro Val Gly Thr Ile Leu Ala Ile Ile Thr Thr Ser 
            420                 425                 430         


Leu Val Tyr Phe Ser Ser Val Val Leu Phe Gly Ala Cys Ile Glu Gly 
        435                 440                 445             


Val Val Leu Arg Asp Lys Tyr Gly Asp Gly Val Ser Arg Asn Leu Val 
    450                 455                 460                 


Val Gly Thr Leu Ala Trp Pro Ser Pro Trp Val Ile Val Ile Gly Ser 
465                 470                 475                 480 


Phe Phe Ser Thr Cys Gly Ala Gly Leu Gln Ser Leu Thr Gly Ala Pro 
                485                 490                 495     


Arg Leu Leu Gln Ala Ile Ala Lys Asp Asn Ile Ile Pro Phe Leu Arg 
            500                 505                 510         


Val Phe Gly His Gly Lys Val Asn Gly Glu Pro Thr Trp Ala Leu Leu 
        515                 520                 525             


Leu Thr Ala Leu Ile Ala Glu Leu Gly Ile Leu Ile Ala Ser Leu Asp 
    530                 535                 540                 


Met Val Ala Pro Ile Leu Ser Met Phe Phe Leu Met Cys Tyr Leu Phe 
545                 550                 555                 560 


Val Asn Leu Ala Cys Ala Val Gln Thr Leu Leu Arg Thr Pro Asn Trp 
                565                 570                 575     


Arg Pro Arg Phe Lys Tyr Tyr His Trp Ala Leu Ser Phe Leu Gly Met 
            580                 585                 590         


Ser Leu Cys Leu Ala Leu Met Phe Val Ser Ser Trp Tyr Tyr Ala Leu 
        595                 600                 605             


Val Ala Met Leu Ile Ala Gly Met Ile Tyr Lys Tyr Ile Glu Tyr Gln 
    610                 615                 620                 


Gly Ala Glu Lys Glu Trp Gly Asp Gly Ile Arg Gly Leu Ser Leu Ser 
625                 630                 635                 640 


Ala Ala Arg Tyr Ala Leu Leu Arg Leu Glu Glu Gly Pro Pro His Thr 
                645                 650                 655     


Lys Asn Trp Arg Pro Gln Leu Leu Val Leu Leu Lys Leu Asp Glu Asp 
            660                 665                 670         


Leu His Val Lys Tyr Pro Arg Leu Leu Thr Phe Ala Ser Gln Leu Lys 
        675                 680                 685             


Ala Gly Lys Gly Leu Thr Ile Val Gly Ser Val Ile Gln Gly Ser Phe 
    690                 695                 700                 


Leu Glu Ser Tyr Gly Glu Ala Gln Ala Ala Glu Gln Thr Ile Lys Asn 
705                 710                 715                 720 


Met Met Glu Ile Glu Lys Val Lys Gly Phe Cys Gln Val Val Val Ala 
                725                 730                 735     


Ser Lys Val Arg Glu Gly Leu Ala His Leu Ile Gln Ser Cys Gly Leu 
            740                 745                 750         


Gly Gly Met Arg His Asn Ser Val Val Leu Gly Trp Pro Tyr Gly Trp 
        755                 760                 765             


Arg Gln Ser Glu Asp Pro Arg Ala Trp Lys Thr Phe Ile Asp Thr Val 
    770                 775                 780                 


Arg Cys Thr Thr Ala Ala His Leu Ala Leu Leu Val Pro Lys Asn Ile 
785                 790                 795                 800 


Ala Phe Tyr Pro Ser Asn His Glu Arg Tyr Leu Glu Gly His Ile Asp 
                805                 810                 815     


Val Trp Trp Ile Val His Asp Gly Gly Met Leu Met Leu Leu Pro Phe 
            820                 825                 830         


Leu Leu Arg Gln His Lys Val Trp Arg Lys Cys Arg Met Arg Ile Phe 
        835                 840                 845             


Thr Val Ala Gln Met Asp Asp Asn Ser Ile Gln Met Lys Lys Asp Leu 
    850                 855                 860                 


Ala Val Phe Leu Tyr His Leu Arg Leu Glu Ala Glu Val Glu Val Val 
865                 870                 875                 880 


Glu Met His Asn Ser Asp Ile Ser Ala Tyr Thr Tyr Glu Arg Thr Leu 
                885                 890                 895     


Met Met Glu Gln Arg Ser Gln Met Leu Arg Gln Met Arg Leu Thr Lys 
            900                 905                 910         


Thr Glu Arg Glu Arg Glu Ala Gln Leu Val Lys Asp Arg His Ser Ala 
        915                 920                 925             


Leu Arg Leu Glu Ser Leu Tyr Ser Asp Glu Glu Asp Glu Ser Ala Val 
    930                 935                 940                 


Gly Ala Asp Lys Ile Gln Met Thr Trp Thr Arg Asp Lys Tyr Met Thr 
945                 950                 955                 960 


Glu Thr Trp Asp Pro Ser His Ala Pro Asp Asn Phe Arg Glu Leu Val 
                965                 970                 975     


His Ile Lys Pro Asp Gln Ser Asn Val Arg Arg Met His Thr Ala Val 
            980                 985                 990         


Lys Leu Asn Glu Val Ile Val Thr  Arg Ser His Asp Ala  Arg Leu Val 
        995                 1000                 1005             


Leu Leu  Asn Met Pro Gly Pro  Pro Arg Asn Ser Glu  Gly Asp Glu 
    1010                 1015                 1020             


Asn Tyr  Met Glu Phe Leu Glu  Val Leu Thr Glu Gly  Leu Glu Arg 
    1025                 1030                 1035             


Val Leu  Leu Val Arg Gly Gly  Gly Arg Glu Val Ile  Thr Ile Tyr 
    1040                 1045                 1050             


Ser 
    


<210>  1892
<211>  641
<212>  PRT
<213>  Homo sapiens

<400>  1892

Met Ala Thr Cys Trp Gln Ala Leu Trp Ala Tyr Arg Ser Tyr Leu Ile 
1               5                   10                  15      


Val Phe Phe Val Pro Ile Leu Leu Leu Pro Leu Pro Ile Leu Val Pro 
            20                  25                  30          


Ser Lys Glu Ala Tyr Cys Ala Tyr Ala Ile Ile Leu Met Ala Leu Phe 
        35                  40                  45              


Trp Cys Thr Glu Ala Leu Pro Leu Ala Val Thr Ala Leu Phe Pro Leu 
    50                  55                  60                  


Ile Leu Phe Pro Met Met Gly Ile Val Asp Ala Ser Glu Ile Ile Gln 
65                  70                  75                  80  


Arg Pro Phe Pro Ser Ser Phe Glu Ser Pro Gly Glu Cys Gln Ser Val 
                85                  90                  95      


Gly Met Ser Val Thr Ala Ser His Asn Leu Gly Gly Thr Val Gly Asp 
            100                 105                 110         


Ser Arg Val Phe Pro Pro Leu Ser His Val Ser Thr Cys Gln Val Ala 
        115                 120                 125             


Val Glu Tyr Leu Lys Asp Ser Asn Leu Leu Phe Phe Gly Gly Leu Leu 
    130                 135                 140                 


Val Ala Ile Ala Val Glu His Trp Asn Leu His Lys Arg Ile Ala Leu 
145                 150                 155                 160 


Arg Val Leu Leu Ile Val Gly Val Arg Pro Ala Pro Leu Ile Leu Gly 
                165                 170                 175     


Phe Met Leu Val Thr Ala Phe Leu Ser Met Trp Ile Ser Asn Thr Ala 
            180                 185                 190         


Thr Ser Ala Met Met Val Pro Ile Ala His Ala Val Leu Asp Gln Leu 
        195                 200                 205             


His Ser Ser Gln Ala Ser Ser Asn Val Glu Glu Gly Ser Asn Asn Pro 
    210                 215                 220                 


Thr Phe Glu Leu Gln Glu Pro Ser Pro Gln Lys Glu Val Thr Lys Leu 
225                 230                 235                 240 


Asp Asn Gly Gln Ala Leu Pro Val Thr Ser Ala Ser Ser Glu Gly Arg 
                245                 250                 255     


Ala His Leu Ser Gln Lys His Leu His Leu Thr Gln Cys Met Ser Leu 
            260                 265                 270         


Cys Val Cys Tyr Ser Ala Ser Ile Gly Gly Ile Ala Thr Leu Thr Gly 
        275                 280                 285             


Thr Ala Pro Asn Leu Val Leu Gln Gly Gln Ile Asn Ser Leu Phe Pro 
    290                 295                 300                 


Gln Asn Gly Asn Val Val Asn Phe Ala Ser Trp Phe Ser Phe Ala Phe 
305                 310                 315                 320 


Pro Thr Met Val Ile Leu Leu Leu Leu Ala Trp Leu Trp Leu Gln Ile 
                325                 330                 335     


Leu Phe Leu Gly Phe Asn Phe Arg Lys Asn Phe Gly Ile Gly Glu Lys 
            340                 345                 350         


Met Gln Glu Gln Gln Gln Ala Ala Tyr Cys Val Ile Gln Thr Glu His 
        355                 360                 365             


Arg Leu Leu Gly Pro Met Thr Phe Ala Glu Lys Ala Ile Ser Ile Leu 
    370                 375                 380                 


Phe Val Ile Leu Val Leu Leu Trp Phe Thr Arg Glu Pro Gly Phe Phe 
385                 390                 395                 400 


Leu Gly Trp Gly Asn Leu Ala Phe Pro Asn Ala Lys Gly Glu Ser Met 
                405                 410                 415     


Val Ser Asp Gly Thr Val Ala Ile Phe Ile Gly Ile Ile Met Phe Ile 
            420                 425                 430         


Ile Pro Ser Lys Phe Pro Gly Leu Thr Gln Asp Pro Glu Asn Pro Gly 
        435                 440                 445             


Lys Leu Lys Ala Pro Leu Gly Leu Leu Asp Trp Lys Thr Val Asn Gln 
    450                 455                 460                 


Lys Met Pro Trp Asn Ile Val Leu Leu Leu Gly Gly Gly Tyr Ala Leu 
465                 470                 475                 480 


Ala Lys Gly Ser Glu Arg Ser Gly Leu Ser Glu Trp Leu Gly Asn Lys 
                485                 490                 495     


Leu Thr Pro Leu Gln Ser Val Pro Ala Pro Ala Ile Ala Ile Ile Leu 
            500                 505                 510         


Ser Leu Leu Val Ala Thr Phe Thr Glu Cys Thr Ser Asn Val Ala Thr 
        515                 520                 525             


Thr Thr Ile Phe Leu Pro Ile Leu Ala Ser Met Ala Gln Ala Ile Cys 
    530                 535                 540                 


Leu His Pro Leu Tyr Val Met Leu Pro Cys Thr Leu Ala Thr Ser Leu 
545                 550                 555                 560 


Ala Phe Met Leu Pro Val Ala Thr Pro Pro Asn Ala Ile Val Phe Ser 
                565                 570                 575     


Phe Gly Asp Leu Lys Val Leu Asp Met Ala Arg Ala Gly Phe Leu Leu 
            580                 585                 590         


Asn Ile Ile Gly Val Leu Ile Ile Ala Leu Ala Ile Asn Ser Trp Gly 
        595                 600                 605             


Ile Pro Leu Phe Ser Leu His Ser Phe Pro Ser Trp Ala Gln Ser Asn 
    610                 615                 620                 


Thr Thr Ala Gln Cys Leu Pro Ser Leu Ala Asn Thr Thr Thr Pro Ser 
625                 630                 635                 640 


Pro 
    


<210>  1893
<211>  641
<212>  PRT
<213>  Homo sapiens

<400>  1893

Met Ala Thr Cys Trp Gln Ala Leu Trp Ala Tyr Arg Ser Tyr Leu Ile 
1               5                   10                  15      


Val Phe Phe Val Pro Ile Leu Leu Leu Pro Leu Pro Ile Leu Val Pro 
            20                  25                  30          


Ser Lys Glu Ala Tyr Cys Ala Tyr Ala Ile Ile Leu Met Ala Leu Phe 
        35                  40                  45              


Trp Cys Thr Glu Ala Leu Pro Leu Ala Val Thr Ala Leu Phe Pro Leu 
    50                  55                  60                  


Ile Leu Phe Pro Met Met Gly Ile Val Asp Ala Ser Glu Ile Ile Gln 
65                  70                  75                  80  


Arg Pro Phe Pro Ser Ser Phe Glu Ser Pro Gly Glu Cys Gln Ser Val 
                85                  90                  95      


Gly Met Ser Val Thr Ala Ser His Asn Leu Gly Gly Thr Val Gly Asp 
            100                 105                 110         


Ser Arg Val Phe Pro Pro Leu Ser His Val Ser Thr Cys Gln Val Ala 
        115                 120                 125             


Val Glu Tyr Leu Lys Asp Ser Asn Leu Leu Phe Phe Gly Gly Leu Leu 
    130                 135                 140                 


Val Ala Ile Ala Val Glu His Trp Asn Leu His Lys Arg Ile Ala Leu 
145                 150                 155                 160 


Arg Val Leu Leu Ile Val Gly Val Arg Pro Ala Pro Leu Ile Leu Gly 
                165                 170                 175     


Phe Met Leu Val Thr Ala Phe Leu Ser Met Trp Ile Ser Asn Thr Ala 
            180                 185                 190         


Thr Ser Ala Met Met Val Pro Ile Ala His Ala Val Leu Asp Gln Leu 
        195                 200                 205             


His Ser Ser Gln Ala Ser Ser Asn Val Glu Glu Gly Ser Asn Asn Pro 
    210                 215                 220                 


Thr Phe Glu Leu Gln Glu Pro Ser Pro Gln Lys Glu Val Thr Lys Leu 
225                 230                 235                 240 


Asp Asn Gly Gln Ala Leu Pro Val Thr Ser Ala Ser Ser Glu Gly Arg 
                245                 250                 255     


Ala His Leu Ser Gln Lys His Leu His Leu Thr Gln Cys Met Ser Leu 
            260                 265                 270         


Cys Val Cys Tyr Ser Ala Ser Ile Gly Gly Ile Ala Thr Leu Thr Gly 
        275                 280                 285             


Thr Ala Pro Asn Leu Val Leu Gln Gly Gln Ile Asn Ser Leu Phe Pro 
    290                 295                 300                 


Gln Asn Gly Asn Val Val Asn Phe Ala Ser Trp Phe Ser Phe Ala Phe 
305                 310                 315                 320 


Pro Thr Met Val Ile Leu Leu Leu Leu Ala Trp Leu Trp Leu Gln Ile 
                325                 330                 335     


Leu Phe Leu Gly Phe Asn Phe Arg Lys Asn Phe Gly Ile Gly Glu Lys 
            340                 345                 350         


Met Gln Glu Gln Gln Gln Ala Ala Tyr Cys Val Ile Gln Thr Glu His 
        355                 360                 365             


Arg Leu Leu Gly Pro Met Thr Phe Ala Glu Lys Ala Ile Ser Ile Leu 
    370                 375                 380                 


Phe Val Ile Leu Val Leu Leu Trp Phe Thr Arg Glu Pro Gly Phe Phe 
385                 390                 395                 400 


Leu Gly Trp Gly Asn Leu Ala Phe Pro Asn Ala Lys Gly Glu Ser Met 
                405                 410                 415     


Val Ser Asp Gly Thr Val Ala Ile Phe Ile Gly Ile Ile Met Phe Ile 
            420                 425                 430         


Ile Pro Ser Lys Phe Pro Gly Leu Thr Gln Asp Pro Glu Asn Pro Gly 
        435                 440                 445             


Lys Leu Lys Ala Pro Leu Gly Leu Leu Asp Trp Lys Thr Val Asn Gln 
    450                 455                 460                 


Lys Met Pro Trp Asn Ile Val Leu Leu Leu Gly Gly Gly Tyr Ala Leu 
465                 470                 475                 480 


Ala Lys Gly Ser Glu Arg Ser Gly Leu Ser Glu Trp Leu Gly Asn Lys 
                485                 490                 495     


Leu Thr Pro Leu Gln Ser Val Pro Ala Pro Ala Ile Ala Ile Ile Leu 
            500                 505                 510         


Ser Leu Leu Val Ala Thr Phe Thr Glu Cys Thr Ser Asn Val Ala Thr 
        515                 520                 525             


Thr Thr Ile Phe Leu Pro Ile Leu Ala Ser Met Ala Gln Ala Ile Cys 
    530                 535                 540                 


Leu His Pro Leu Tyr Val Met Leu Pro Cys Thr Leu Ala Thr Ser Leu 
545                 550                 555                 560 


Ala Phe Met Leu Pro Val Ala Thr Pro Pro Asn Ala Ile Val Phe Ser 
                565                 570                 575     


Phe Gly Asp Leu Lys Val Leu Asp Met Ala Arg Ala Gly Phe Leu Leu 
            580                 585                 590         


Asn Ile Ile Gly Val Leu Ile Ile Ala Leu Ala Ile Asn Ser Trp Gly 
        595                 600                 605             


Ile Pro Leu Phe Ser Leu His Ser Phe Pro Ser Trp Ala Gln Ser Asn 
    610                 615                 620                 


Thr Thr Ala Gln Cys Leu Pro Ser Leu Ala Asn Thr Thr Thr Pro Ser 
625                 630                 635                 640 


Pro 
    


<210>  1894
<211>  698
<212>  PRT
<213>  Homo sapiens

<400>  1894

Met Asn Pro Phe Gln Lys Asn Glu Ser Lys Glu Thr Leu Phe Ser Pro 
1               5                   10                  15      


Val Ser Ile Glu Glu Val Pro Pro Arg Pro Pro Ser Pro Pro Lys Lys 
            20                  25                  30          


Pro Ser Pro Thr Ile Cys Gly Ser Asn Tyr Pro Leu Ser Ile Ala Phe 
        35                  40                  45              


Ile Val Val Asn Glu Phe Cys Glu Arg Phe Ser Tyr Tyr Gly Met Lys 
    50                  55                  60                  


Ala Val Leu Ile Leu Tyr Phe Leu Tyr Phe Leu His Trp Asn Glu Asp 
65                  70                  75                  80  


Thr Ser Thr Ser Ile Tyr His Ala Phe Ser Ser Leu Cys Tyr Phe Thr 
                85                  90                  95      


Pro Ile Leu Gly Ala Ala Ile Ala Asp Ser Trp Leu Gly Lys Phe Lys 
            100                 105                 110         


Val Leu Ser Leu Ile Gly Leu Ser Leu Ile Ala Leu Gly Thr Gly Gly 
        115                 120                 125             


Ile Lys Pro Cys Val Ala Ala Phe Gly Gly Asp Gln Phe Glu Glu Lys 
    130                 135                 140                 


His Ala Glu Glu Arg Thr Arg Tyr Phe Ser Val Phe Tyr Leu Ser Ile 
145                 150                 155                 160 


Asn Ala Gly Ser Leu Ile Ser Thr Phe Ile Thr Pro Met Leu Arg Gly 
                165                 170                 175     


Asp Val Gln Cys Phe Gly Glu Asp Cys Tyr Ala Leu Ala Phe Gly Val 
            180                 185                 190         


Pro Gly Leu Leu Met Val Ile Ala Leu Val Val Phe Ala Met Gly Ser 
        195                 200                 205             


Lys Ile Tyr Asn Lys Pro Pro Pro Glu Gly Asn Ile Val Ala Gln Val 
    210                 215                 220                 


Phe Lys Cys Ile Trp Phe Ala Ile Ser Asn Arg Phe Lys Asn Arg Ser 
225                 230                 235                 240 


Gly Asp Ile Pro Lys Arg Gln His Trp Leu Asp Trp Ala Ala Glu Lys 
                245                 250                 255     


Tyr Pro Lys Gln Leu Ile Met Asp Val Lys Ala Leu Thr Arg Val Leu 
            260                 265                 270         


Phe Leu Tyr Ile Pro Leu Pro Met Phe Trp Ala Leu Leu Asp Gln Gln 
        275                 280                 285             


Gly Ser Arg Trp Thr Leu Gln Ala Ile Arg Met Asn Arg Asn Leu Gly 
    290                 295                 300                 


Phe Phe Val Leu Gln Pro Asp Gln Met Gln Val Leu Asn Pro Leu Leu 
305                 310                 315                 320 


Val Leu Ile Phe Ile Pro Leu Phe Asp Phe Val Ile Tyr Arg Leu Val 
                325                 330                 335     


Ser Lys Cys Gly Ile Asn Phe Ser Ser Leu Arg Lys Met Ala Val Gly 
            340                 345                 350         


Met Ile Leu Ala Cys Leu Ala Phe Ala Val Ala Ala Ala Val Glu Ile 
        355                 360                 365             


Lys Ile Asn Glu Met Ala Pro Ala Gln Pro Gly Pro Gln Glu Val Phe 
    370                 375                 380                 


Leu Gln Val Leu Asn Leu Ala Asp Asp Glu Val Lys Val Thr Val Val 
385                 390                 395                 400 


Gly Asn Glu Asn Asn Ser Leu Leu Ile Glu Ser Ile Lys Ser Phe Gln 
                405                 410                 415     


Lys Thr Pro His Tyr Ser Lys Leu His Leu Lys Thr Lys Ser Gln Asp 
            420                 425                 430         


Phe His Phe His Leu Lys Tyr His Asn Leu Ser Leu Tyr Thr Glu His 
        435                 440                 445             


Ser Val Gln Glu Lys Asn Trp Tyr Ser Leu Val Ile Arg Glu Asp Gly 
    450                 455                 460                 


Asn Ser Ile Ser Ser Met Met Val Lys Asp Thr Glu Ser Arg Thr Thr 
465                 470                 475                 480 


Asn Gly Met Thr Thr Val Arg Phe Val Asn Thr Leu His Lys Asp Val 
                485                 490                 495     


Asn Ile Ser Leu Ser Thr Asp Thr Ser Leu Asn Val Gly Glu Asp Tyr 
            500                 505                 510         


Gly Val Ser Ala Tyr Arg Thr Val Gln Arg Gly Glu Tyr Pro Ala Val 
        515                 520                 525             


His Cys Arg Thr Glu Asp Lys Asn Phe Ser Leu Asn Leu Gly Leu Leu 
    530                 535                 540                 


Asp Phe Gly Ala Ala Tyr Leu Phe Val Ile Thr Asn Asn Thr Asn Gln 
545                 550                 555                 560 


Gly Leu Gln Ala Trp Lys Ile Glu Asp Ile Pro Ala Asn Lys Met Ser 
                565                 570                 575     


Ile Ala Trp Gln Leu Pro Gln Tyr Ala Leu Val Thr Ala Gly Glu Val 
            580                 585                 590         


Met Phe Ser Val Thr Gly Leu Glu Phe Ser Tyr Ser Gln Ala Pro Ser 
        595                 600                 605             


Ser Met Lys Ser Val Leu Gln Ala Ala Trp Leu Leu Thr Ile Ala Val 
    610                 615                 620                 


Gly Asn Ile Ile Val Leu Val Val Ala Gln Phe Ser Gly Leu Val Gln 
625                 630                 635                 640 


Trp Ala Glu Phe Ile Leu Phe Ser Cys Leu Leu Leu Val Ile Cys Leu 
                645                 650                 655     


Ile Phe Ser Ile Met Gly Tyr Tyr Tyr Val Pro Val Lys Thr Glu Asp 
            660                 665                 670         


Met Arg Gly Pro Ala Asp Lys His Ile Pro His Ile Gln Gly Asn Met 
        675                 680                 685             


Ile Lys Leu Glu Thr Lys Lys Thr Lys Leu 
    690                 695             


<210>  1895
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  1895

Met Asp Glu Gly Thr Gly Leu Gln Pro Gly Ala Gly Glu Gln Leu Glu 
1               5                   10                  15      


Ala Pro Ala Thr Ala Glu Ala Val Gln Glu Arg Cys Glu Pro Glu Thr 
            20                  25                  30          


Leu Arg Ser Lys Ser Leu Pro Val Leu Ser Ser Ala Ser Cys Arg Pro 
        35                  40                  45              


Ser Leu Ser Pro Thr Ser Gly Asp Ala Asn Pro Ala Phe Gly Cys Val 
    50                  55                  60                  


Asp Ser Ser Gly His Gln Glu Leu Lys Gln Gly Pro Asn Pro Leu Ala 
65                  70                  75                  80  


Pro Ser Pro Ser Ala Pro Ser Thr Ser Ala Gly Leu Gly Asp Cys Asn 
                85                  90                  95      


His Arg Val Asp Leu Ser Lys Thr Phe Ser Val Ser Ser Ala Leu Ala 
            100                 105                 110         


Met Leu Gln Glu Arg Arg Cys Leu Tyr Val Val Leu Thr Asp Ser Arg 
        115                 120                 125             


Cys Phe Leu Val Cys Met Cys Phe Leu Thr Phe Ile Gln Ala Leu Met 
    130                 135                 140                 


Val Ser Gly Tyr Leu Ser Ser Val Ile Thr Thr Ile Glu Arg Arg Tyr 
145                 150                 155                 160 


Ser Leu Lys Ser Ser Glu Ser Gly Leu Leu Val Ser Cys Phe Asp Ile 
                165                 170                 175     


Gly Asn Leu Val Val Val Val Phe Val Ser Tyr Phe Gly Gly Arg Gly 
            180                 185                 190         


Arg Arg Pro Leu Trp Leu Ala Val Gly Gly Leu Leu Ile Ala Phe Gly 
        195                 200                 205             


Ala Ala Leu Phe Ala Leu Pro His Phe Ile Ser Pro Pro Tyr Gln Ile 
    210                 215                 220                 


Gln Glu Leu Asn Ala Ser Ala Pro Asn Asp Gly Leu Cys Gln Gly Gly 
225                 230                 235                 240 


Asn Ser Thr Ala Thr Leu Glu Pro Pro Ala Cys Pro Lys Asp Ser Gly 
                245                 250                 255     


Gly Asn Asn His Trp Val Tyr Val Ala Leu Phe Ile Cys Ala Gln Ile 
            260                 265                 270         


Leu Ile Gly Met Gly Ser Thr Pro Ile Tyr Thr Leu Gly Pro Thr Tyr 
        275                 280                 285             


Leu Asp Asp Asn Val Lys Lys Glu Asn Ser Ser Leu Tyr Leu Ala Ile 
    290                 295                 300                 


Met Tyr Val Met Gly Ala Leu Gly Pro Ala Val Gly Tyr Leu Leu Gly 
305                 310                 315                 320 


Gly Leu Leu Ile Gly Phe Tyr Val Asp Pro Arg Asn Pro Val His Leu 
                325                 330                 335     


Asp Gln Asn Asp Pro Arg Phe Ile Gly Asn Trp Trp Ser Gly Phe Leu 
            340                 345                 350         


Leu Cys Ala Ile Ala Met Phe Leu Val Ile Phe Pro Met Phe Thr Phe 
        355                 360                 365             


Pro Lys Lys Leu Pro Pro Arg His Lys Lys Lys Lys Lys Lys Lys Phe 
    370                 375                 380                 


Ser Val Asp Ala Val Ser Asp Asp Asp Val Leu Lys Glu Lys Ser Asn 
385                 390                 395                 400 


Asn Ser Glu Gln Ala Asp Lys Lys Val Ser Ser Met Gly Phe Gly Lys 
                405                 410                 415     


Asp Val Arg Asp Leu Pro Arg Ala Ala Val Arg Ile Leu Ser Asn Met 
            420                 425                 430         


Thr Phe Leu Phe Val Ser Leu Ser Tyr Thr Ala Glu Ser Ala Ile Val 
        435                 440                 445             


Thr Ala Phe Ile Thr Phe Ile Pro Lys Phe Ile Glu Ser Gln Phe Gly 
    450                 455                 460                 


Ile Pro Ala Ser Asn Ala Ser Ile Tyr Thr Gly Val Ile Ile Val Pro 
465                 470                 475                 480 


Ser Ala Gly Val Gly Ile Val Leu Gly Gly Tyr Ile Ile Lys Lys Leu 
                485                 490                 495     


Lys Leu Gly Ala Arg Glu Ser Ala Lys Leu Ala Met Ile Cys Ser Gly 
            500                 505                 510         


Val Ser Leu Leu Cys Phe Ser Thr Leu Phe Ile Val Gly Cys Glu Ser 
        515                 520                 525             


Ile Asn Leu Gly Gly Ile Asn Ile Pro Tyr Thr Thr Gly Pro Ser Leu 
    530                 535                 540                 


Thr Met Pro His Arg Asn Leu Thr Gly Ser Cys Asn Val Asn Cys Gly 
545                 550                 555                 560 


Cys Lys Ile His Glu Tyr Glu Pro Val Cys Gly Ser Asp Gly Ile Thr 
                565                 570                 575     


Tyr Phe Asn Pro Cys Leu Ala Gly Cys Val Asn Ser Gly Asn Leu Ser 
            580                 585                 590         


Thr Gly Ile Arg Asn Tyr Thr Glu Cys Thr Cys Val Gln Ser Arg Gln 
        595                 600                 605             


Val Ile Thr Pro Pro Thr Val Gly Gln Arg Ser Gln Leu Arg Val Val 
    610                 615                 620                 


Ile Val Lys Thr Tyr Leu Asn Glu Asn Gly Tyr Ala Val Ser Gly Lys 
625                 630                 635                 640 


Cys Lys Arg Thr Cys Asn Thr Leu Ile Pro Phe Leu Val Phe Leu Phe 
                645                 650                 655     


Ile Val Thr Phe Ile Thr Ala Cys Ala Gln Pro Ser Ala Ile Ile Val 
            660                 665                 670         


Thr Leu Ser Ile His Ser Tyr Ser Asn Leu Leu Trp Ser Ser His 
        675                 680                 685         


<210>  1896
<211>  793
<212>  PRT
<213>  Homo sapiens

<400>  1896

Met Asp Glu Gly Thr Gly Leu Gln Pro Gly Ala Gly Glu Gln Leu Glu 
1               5                   10                  15      


Ala Pro Ala Thr Ala Glu Ala Val Gln Glu Arg Cys Glu Pro Glu Thr 
            20                  25                  30          


Leu Arg Ser Lys Ser Leu Pro Val Leu Ser Ser Ala Ser Cys Arg Pro 
        35                  40                  45              


Ser Leu Ser Pro Thr Ser Gly Asp Ala Asn Pro Ala Phe Gly Cys Val 
    50                  55                  60                  


Asp Ser Ser Gly His Gln Glu Leu Lys Gln Gly Pro Asn Pro Leu Ala 
65                  70                  75                  80  


Pro Ser Pro Ser Ala Pro Ser Thr Ser Ala Gly Leu Gly Asp Cys Asn 
                85                  90                  95      


His Arg Val Asp Leu Ser Lys Thr Phe Ser Val Ser Ser Ala Leu Ala 
            100                 105                 110         


Met Leu Gln Glu Arg Arg Cys Leu Tyr Val Val Leu Thr Asp Ser Arg 
        115                 120                 125             


Cys Phe Leu Val Cys Met Cys Phe Leu Thr Phe Ile Gln Ala Leu Met 
    130                 135                 140                 


Val Ser Gly Tyr Leu Ser Ser Val Ile Thr Thr Ile Glu Arg Arg Tyr 
145                 150                 155                 160 


Ser Leu Lys Ser Ser Glu Ser Gly Leu Leu Val Ser Cys Phe Asp Ile 
                165                 170                 175     


Gly Asn Leu Val Val Val Val Phe Val Ser Tyr Phe Gly Gly Arg Gly 
            180                 185                 190         


Arg Arg Pro Leu Trp Leu Ala Val Gly Gly Leu Leu Ile Ala Phe Gly 
        195                 200                 205             


Ala Ala Leu Phe Ala Leu Pro His Phe Ile Ser Pro Pro Tyr Gln Ile 
    210                 215                 220                 


Gln Glu Leu Asn Ala Ser Ala Pro Asn Asp Gly Leu Cys Gln Gly Gly 
225                 230                 235                 240 


Asn Ser Thr Ala Thr Leu Glu Pro Pro Ala Cys Pro Lys Asp Ser Gly 
                245                 250                 255     


Gly Asn Asn His Trp Val Tyr Val Ala Leu Phe Ile Cys Ala Gln Ile 
            260                 265                 270         


Leu Ile Gly Met Gly Ser Thr Pro Ile Tyr Thr Leu Gly Pro Thr Tyr 
        275                 280                 285             


Leu Asp Asp Asn Val Lys Lys Glu Asn Ser Ser Leu Tyr Leu Ala Ile 
    290                 295                 300                 


Met Tyr Val Met Gly Ala Leu Gly Pro Ala Val Gly Tyr Leu Leu Gly 
305                 310                 315                 320 


Gly Leu Leu Ile Gly Phe Tyr Val Asp Pro Arg Asn Pro Val His Leu 
                325                 330                 335     


Asp Gln Asn Asp Pro Arg Phe Ile Gly Asn Trp Trp Ser Gly Phe Leu 
            340                 345                 350         


Leu Cys Ala Ile Ala Met Phe Leu Val Ile Phe Pro Met Phe Thr Phe 
        355                 360                 365             


Pro Lys Lys Leu Pro Pro Arg His Lys Lys Lys Lys Lys Lys Lys Phe 
    370                 375                 380                 


Ser Val Asp Ala Val Ser Asp Asp Asp Val Leu Lys Glu Lys Ser Asn 
385                 390                 395                 400 


Asn Ser Glu Gln Ala Asp Lys Lys Val Ser Ser Met Gly Phe Gly Lys 
                405                 410                 415     


Asp Val Arg Gly Val Ile Ile Val Pro Ser Ala Gly Val Gly Ile Val 
            420                 425                 430         


Leu Gly Gly Tyr Ile Ile Lys Lys Leu Lys Leu Gly Ala Arg Glu Ser 
        435                 440                 445             


Ala Lys Leu Ala Met Ile Cys Ser Gly Val Ser Leu Leu Cys Phe Ser 
    450                 455                 460                 


Thr Leu Phe Ile Val Gly Cys Glu Ser Ile Asn Leu Gly Gly Ile Asn 
465                 470                 475                 480 


Ile Pro Tyr Thr Thr Gly Pro Ser Leu Thr Met Pro His Arg Asn Leu 
                485                 490                 495     


Thr Gly Ser Cys Asn Val Asn Cys Gly Cys Lys Ile His Glu Tyr Glu 
            500                 505                 510         


Pro Val Cys Gly Ser Asp Gly Ile Thr Tyr Phe Asn Pro Cys Leu Ala 
        515                 520                 525             


Gly Cys Val Asn Ser Gly Asn Leu Ser Thr Gly Ile Arg Asn Tyr Thr 
    530                 535                 540                 


Glu Cys Thr Cys Val Gln Ser Arg Gln Val Ile Thr Pro Pro Thr Val 
545                 550                 555                 560 


Gly Gln Arg Ser Gln Leu Arg Val Val Ile Val Lys Thr Tyr Leu Asn 
                565                 570                 575     


Glu Asn Gly Tyr Ala Val Ser Gly Lys Cys Lys Arg Thr Cys Asn Thr 
            580                 585                 590         


Leu Ile Pro Phe Leu Val Phe Leu Phe Ile Val Thr Phe Ile Thr Ala 
        595                 600                 605             


Cys Ala Gln Pro Ser Ala Ile Ile Val Thr Leu Arg Ser Val Glu Asp 
    610                 615                 620                 


Glu Glu Arg Pro Phe Ala Leu Gly Met Gln Phe Val Leu Leu Arg Thr 
625                 630                 635                 640 


Leu Ala Tyr Ile Pro Thr Pro Ile Tyr Phe Gly Ala Val Ile Asp Thr 
                645                 650                 655     


Thr Cys Met Leu Trp Gln Gln Glu Cys Gly Val Gln Gly Ser Cys Trp 
            660                 665                 670         


Glu Tyr Asn Val Thr Ser Phe Arg Phe Val Tyr Phe Gly Leu Ala Ala 
        675                 680                 685             


Gly Leu Lys Phe Val Gly Phe Ile Phe Ile Phe Leu Ala Trp Tyr Ser 
    690                 695                 700                 


Ile Lys Tyr Lys Glu Asp Gly Leu Gln Arg Arg Arg Gln Arg Glu Phe 
705                 710                 715                 720 


Pro Leu Ser Thr Val Ser Glu Arg Val Gly His Pro Asp Asn Ala Arg 
                725                 730                 735     


Thr Arg Ser Cys Pro Ala Phe Ser Thr Gln Gly Glu Phe His Glu Glu 
            740                 745                 750         


Thr Gly Leu Gln Lys Gly Ile Gln Cys Ala Ala Gln Thr Tyr Pro Gly 
        755                 760                 765             


Pro Phe Pro Glu Ala Ile Ser Ser Ser Ala Asp Pro Gly Leu Glu Glu 
    770                 775                 780                 


Ser Pro Ala Ala Leu Glu Pro Pro Ser 
785                 790             


<210>  1897
<211>  389
<212>  PRT
<213>  Homo sapiens

<400>  1897

Met Glu Asp Ser Pro Thr Met Val Arg Val Asp Ser Pro Thr Met Val 
1               5                   10                  15      


Arg Gly Glu Asn Gln Val Ser Pro Cys Gln Gly Arg Arg Cys Phe Pro 
            20                  25                  30          


Lys Ala Leu Gly Tyr Val Thr Gly Asp Met Lys Glu Leu Ala Asn Gln 
        35                  40                  45              


Leu Lys Asp Lys Pro Val Val Leu Gln Phe Ile Asp Trp Ile Leu Arg 
    50                  55                  60                  


Gly Ile Ser Gln Val Val Phe Val Asn Asn Pro Val Ser Gly Ile Leu 
65                  70                  75                  80  


Ile Leu Val Gly Leu Leu Val Gln Asn Pro Trp Trp Ala Leu Thr Gly 
                85                  90                  95      


Trp Leu Gly Thr Val Val Ser Thr Leu Met Ala Leu Leu Leu Ser Gln 
            100                 105                 110         


Asp Arg Ser Leu Ile Ala Ser Gly Leu Tyr Gly Tyr Asn Ala Thr Leu 
        115                 120                 125             


Val Gly Val Leu Met Ala Val Phe Ser Asp Lys Gly Asp Tyr Phe Trp 
    130                 135                 140                 


Trp Leu Leu Leu Pro Val Cys Ala Met Ser Met Thr Cys Pro Ile Phe 
145                 150                 155                 160 


Ser Ser Ala Leu Asn Ser Met Leu Ser Lys Trp Asp Leu Pro Val Phe 
                165                 170                 175     


Thr Leu Pro Phe Asn Met Ala Leu Ser Met Tyr Leu Ser Ala Thr Gly 
            180                 185                 190         


His Tyr Asn Pro Phe Phe Pro Ala Lys Leu Val Ile Pro Ile Thr Thr 
        195                 200                 205             


Ala Pro Asn Ile Ser Trp Ser Asp Leu Ser Ala Leu Glu Leu Leu Lys 
    210                 215                 220                 


Ser Ile Pro Val Gly Val Gly Gln Ile Tyr Gly Cys Asp Asn Pro Trp 
225                 230                 235                 240 


Thr Gly Gly Ile Phe Leu Gly Ala Ile Leu Leu Ser Ser Pro Leu Met 
                245                 250                 255     


Cys Leu His Ala Ala Ile Gly Ser Leu Leu Gly Ile Ala Ala Gly Leu 
            260                 265                 270         


Ser Leu Ser Ala Pro Phe Glu Asp Ile Tyr Phe Gly Leu Trp Gly Phe 
        275                 280                 285             


Asn Ser Ser Leu Ala Cys Ile Ala Met Gly Gly Met Phe Met Ala Leu 
    290                 295                 300                 


Thr Trp Gln Thr His Leu Leu Ala Leu Gly Cys Ala Leu Phe Thr Ala 
305                 310                 315                 320 


Tyr Leu Gly Val Gly Met Ala Asn Phe Met Ala Glu Val Gly Leu Pro 
                325                 330                 335     


Ala Cys Thr Trp Pro Phe Cys Leu Ala Thr Leu Leu Phe Leu Ile Met 
            340                 345                 350         


Thr Thr Lys Asn Ser Asn Ile Tyr Lys Met Pro Leu Ser Lys Val Thr 
        355                 360                 365             


Tyr Pro Glu Glu Asn Arg Ile Phe Tyr Leu Gln Ala Lys Lys Arg Met 
    370                 375                 380                 


Val Glu Ser Pro Leu 
385                 


<210>  1898
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  1898

Met Asn Gly Arg Ser Leu Ile Gly Gly Ala Gly Asp Ala Arg His Gly 
1               5                   10                  15      


Pro Val Trp Lys Asp Pro Phe Gly Thr Lys Ala Gly Asp Ala Ala Arg 
            20                  25                  30          


Arg Gly Ile Ala Arg Leu Ser Leu Ala Leu Ala Asp Gly Ser Gln Glu 
        35                  40                  45              


Gln Glu Pro Glu Glu Glu Ile Ala Met Glu Asp Ser Pro Thr Met Val 
    50                  55                  60                  


Arg Val Asp Ser Pro Thr Met Val Arg Gly Glu Asn Gln Val Ser Pro 
65                  70                  75                  80  


Cys Gln Gly Arg Arg Cys Phe Pro Lys Ala Leu Gly Tyr Val Thr Gly 
                85                  90                  95      


Asp Met Lys Glu Leu Ala Asn Gln Leu Lys Asp Lys Pro Val Val Leu 
            100                 105                 110         


Gln Phe Ile Asp Trp Ile Leu Arg Gly Ile Ser Gln Val Val Phe Val 
        115                 120                 125             


Asn Asn Pro Val Ser Gly Ile Leu Ile Leu Val Gly Leu Leu Val Gln 
    130                 135                 140                 


Asn Pro Trp Trp Ala Leu Thr Gly Trp Leu Gly Thr Val Val Ser Thr 
145                 150                 155                 160 


Leu Met Ala Leu Leu Leu Ser Gln Asp Arg Ser Leu Ile Ala Ser Gly 
                165                 170                 175     


Leu Tyr Gly Tyr Asn Ala Thr Leu Val Gly Val Leu Met Ala Val Phe 
            180                 185                 190         


Ser Asp Lys Gly Asp Tyr Phe Trp Trp Leu Leu Leu Pro Val Cys Ala 
        195                 200                 205             


Met Ser Met Thr Cys Pro Ile Phe Ser Ser Ala Leu Asn Ser Met Leu 
    210                 215                 220                 


Ser Lys Trp Asp Leu Pro Val Phe Thr Leu Pro Phe Asn Met Ala Leu 
225                 230                 235                 240 


Ser Met Tyr Leu Ser Ala Thr Gly His Tyr Asn Pro Phe Phe Pro Ala 
                245                 250                 255     


Lys Leu Val Ile Pro Ile Thr Thr Ala Pro Asn Ile Ser Trp Ser Asp 
            260                 265                 270         


Leu Ser Ala Leu Glu Leu Leu Lys Ser Ile Pro Val Gly Val Gly Gln 
        275                 280                 285             


Ile Tyr Gly Cys Asp Asn Pro Trp Thr Gly Gly Ile Phe Leu Gly Ala 
    290                 295                 300                 


Ile Leu Leu Ser Ser Pro Leu Met Cys Leu His Ala Ala Ile Gly Ser 
305                 310                 315                 320 


Leu Leu Gly Ile Ala Ala Gly Leu Ser Leu Ser Ala Pro Phe Glu Asp 
                325                 330                 335     


Ile Tyr Phe Gly Leu Trp Gly Phe Asn Ser Ser Leu Ala Cys Ile Ala 
            340                 345                 350         


Met Gly Gly Met Phe Met Ala Leu Thr Trp Gln Thr His Leu Leu Ala 
        355                 360                 365             


Leu Gly Cys Ala Leu Phe Thr Ala Tyr Leu Gly Val Gly Met Ala Asn 
    370                 375                 380                 


Phe Met Ala Glu Val Gly Leu Pro Ala Cys Thr Trp Pro Phe Cys Leu 
385                 390                 395                 400 


Ala Thr Leu Leu Phe Leu Ile Met Thr Thr Lys Asn Ser Asn Ile Tyr 
                405                 410                 415     


Lys Met Pro Leu Ser Lys Val Thr Tyr Pro Glu Glu Asn Arg Ile Phe 
            420                 425                 430         


Tyr Leu Gln Ala Lys Lys Arg Met Val Glu Ser Pro Leu 
        435                 440                 445 


<210>  1899
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  1899

Met Tyr Ser Phe Asn Thr Leu Arg Leu Tyr Leu Trp Glu Thr Ile Val 
1               5                   10                  15      


Phe Phe Ser Leu Ala Ala Ser Lys Glu Ala Glu Ala Ala Arg Ser Ala 
            20                  25                  30          


Pro Lys Pro Met Ser Pro Ser Asp Phe Leu Asp Lys Leu Met Gly Arg 
        35                  40                  45              


Thr Ser Gly Tyr Asp Ala Arg Ile Arg Pro Asn Phe Lys Gly Pro Pro 
    50                  55                  60                  


Val Asn Val Ser Cys Asn Ile Phe Ile Asn Ser Phe Gly Ser Ile Ala 
65                  70                  75                  80  


Glu Thr Thr Met Asp Tyr Arg Val Asn Ile Phe Leu Arg Gln Gln Trp 
                85                  90                  95      


Asn Asp Pro Arg Leu Ala Tyr Asn Glu Tyr Pro Asp Asp Ser Leu Asp 
            100                 105                 110         


Leu Asp Pro Ser Met Leu Asp Ser Ile Trp Lys Pro Asp Leu Phe Phe 
        115                 120                 125             


Ala Asn Glu Lys Gly Ala His Phe His Glu Ile Thr Thr Asp Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Ser Arg Asn Gly Asn Val Leu Tyr Ser Ile Arg Ile 
145                 150                 155                 160 


Thr Leu Thr Leu Ala Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
                165                 170                 175     


Val Gln Thr Cys Ile Met Gln Leu Glu Ser Phe Gly Tyr Thr Met Asn 
            180                 185                 190         


Asp Leu Ile Phe Glu Trp Gln Glu Gln Gly Ala Val Gln Val Ala Asp 
        195                 200                 205             


Gly Leu Thr Leu Pro Gln Phe Ile Leu Lys Glu Glu Lys Asp Leu Arg 
    210                 215                 220                 


Tyr Cys Thr Lys His Tyr Asn Thr Gly Lys Phe Thr Cys Ile Glu Ala 
225                 230                 235                 240 


Arg Phe His Leu Glu Arg Gln Met Gly Tyr Tyr Leu Ile Gln Met Tyr 
                245                 250                 255     


Ile Pro Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile 
            260                 265                 270         


Asn Met Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val 
        275                 280                 285             


Leu Thr Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys 
    290                 295                 300                 


Val Ser Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu 
305                 310                 315                 320 


Phe Val Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser 
                325                 330                 335     


Arg Gln His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His 
            340                 345                 350         


Lys Ser Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly 
        355                 360                 365             


Arg Phe Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala 
    370                 375                 380                 


Lys Asp Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn 
385                 390                 395                 400 


Pro Pro Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe 
                405                 410                 415     


Ile Gln Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro 
            420                 425                 430         


Met Ala Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile 
        435                 440                 445             


Val Arg Arg Glu Asp Val His Asn Gln 
    450                 455         


<210>  1900
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  1900

Met Gly Ser Ser Arg Cys Gly Pro Gly Ala His Pro Val His Leu Trp 
1               5                   10                  15      


Pro Pro His Phe Ala Phe Ser Gly His His Pro Arg Asp Leu Gly Pro 
            20                  25                  30          


His Ser Gly Pro Ala Leu Leu Val Ser Leu Ala Ser Glu Val Gln Asp 
        35                  40                  45              


Leu His Leu Ala Gln Arg Lys Glu Met Ala Ser Gly Phe Ser Lys Gly 
    50                  55                  60                  


Pro Thr Leu Gly Leu Leu Pro Asp Val Pro Ser Leu Met Glu Thr Leu 
65                  70                  75                  80  


Ser Tyr Ser Tyr Cys Tyr Val Gly Ile Met Thr Gly Pro Phe Phe Arg 
                85                  90                  95      


Tyr Arg Thr Tyr Leu Asp Trp Leu Glu Gln Pro Phe Pro Gly Ala Val 
            100                 105                 110         


Pro Ser Leu Arg Pro Leu Leu Arg Arg Ala Trp Pro Ala Pro Leu Phe 
        115                 120                 125             


Gly Leu Leu Phe Leu Leu Ser Ser His Leu Phe Pro Leu Glu Ala Val 
    130                 135                 140                 


Arg Glu Asp Ala Phe Tyr Ala Arg Pro Leu Pro Ala Arg Leu Phe Tyr 
145                 150                 155                 160 


Met Ile Pro Val Phe Phe Ala Phe Arg Met Arg Phe Tyr Val Ala Trp 
                165                 170                 175     


Ile Ala Ala Glu Cys Gly Cys Ile Ala Ala Gly Phe Gly Ala Tyr Pro 
            180                 185                 190         


Val Ala Ala Lys Ala Arg Ala Gly Gly Gly Pro Thr Leu Gln Cys Pro 
        195                 200                 205             


Pro Pro Ser Ser Pro Glu Lys Ala Ala Ser Leu Glu Tyr Asp Tyr Glu 
    210                 215                 220                 


Thr Ile Arg Asn Ile Asp Cys Tyr Ser Thr Asp Phe Cys Val Arg Val 
225                 230                 235                 240 


Arg Asp Gly Met Arg Tyr Trp Asn Met Thr Val Gln Trp Trp Leu Ala 
                245                 250                 255     


Gln Tyr Ile Tyr Lys Ser Ala Pro Ala Arg Ser Tyr Val Leu Arg Ser 
            260                 265                 270         


Ala Trp Thr Met Leu Leu Ser Ala Tyr Trp His Gly Leu His Pro Gly 
        275                 280                 285             


Tyr Tyr Leu Ser Phe Leu Thr Ile Pro Leu Cys Leu Ala Ala Glu Gly 
    290                 295                 300                 


Arg Leu Glu Ser Ala Leu Arg Gly Arg Leu Ser Pro Gly Gly Gln Lys 
305                 310                 315                 320 


Ala Trp Asp Trp Val His Trp Phe Leu Lys Met Arg Ala Tyr Asp Tyr 
                325                 330                 335     


Met Cys Met Gly Phe Val Leu Leu Ser Leu Ala Asp Thr Leu Arg Tyr 
            340                 345                 350         


Trp Ala Ser Ile Tyr Phe Cys Ile His Phe Leu Ala Leu Ala Ala Leu 
        355                 360                 365             


Gly Leu Gly Leu Ala Leu Gly Gly Gly Ser Pro Ser Arg Arg Lys Ala 
    370                 375                 380                 


Ala Ser Gln Pro Thr Ser Leu Ala Pro Glu Lys Leu Arg Glu Glu 
385                 390                 395                 


<210>  1901
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  1901

Met Gly Trp Gly Gly Gly Gly Gly Cys Thr Pro Arg Pro Pro Ile His 
1               5                   10                  15      


Gln Gln Pro Pro Glu Arg Arg Val Val Thr Val Val Phe Leu Gly Leu 
            20                  25                  30          


Leu Leu Asp Leu Leu Ala Phe Thr Leu Leu Leu Pro Leu Leu Pro Gly 
        35                  40                  45              


Leu Leu Glu Ser His Gly Arg Ala His Asp Pro Leu Tyr Gly Ser Trp 
    50                  55                  60                  


Gln Gly Gly Val Asp Trp Phe Ala Thr Ala Ile Gly Met Pro Val Glu 
65                  70                  75                  80  


Lys Arg Tyr Asn Ser Val Leu Phe Gly Gly Leu Ile Gly Ser Ala Phe 
                85                  90                  95      


Ser Val Leu Gln Phe Leu Cys Ala Pro Leu Thr Gly Ala Thr Ser Asp 
            100                 105                 110         


Cys Leu Gly Arg Arg Pro Val Met Leu Leu Cys Leu Met Gly Val Ala 
        115                 120                 125             


Thr Ser Tyr Ala Val Trp Ala Thr Ser Arg Ser Phe Ala Ala Phe Leu 
    130                 135                 140                 


Ala Ser Arg Leu Ile Gly Gly Ile Ser Lys Gly Asn Val Ser Leu Ser 
145                 150                 155                 160 


Thr Ala Ile Val Ala Asp Leu Gly Ser Pro Leu Ala Arg Ser Gln Gly 
                165                 170                 175     


Met Ala Val Ile Gly Val Ala Phe Ser Leu Gly Phe Thr Leu Gly Pro 
            180                 185                 190         


Met Leu Gly Ala Ser Leu Pro Leu Glu Met Ala Pro Trp Phe Ala Leu 
        195                 200                 205             


Leu Phe Ala Ala Ser Asp Leu Leu Phe Ile Phe Cys Phe Leu Pro Glu 
    210                 215                 220                 


Thr Leu Pro Leu Glu Lys Arg Ala Pro Ser Ile Ala Leu Gly Phe Arg 
225                 230                 235                 240 


Asp Ala Ala Asp Leu Leu Ser Pro Leu Ala Leu Leu Arg Phe Ser Ala 
                245                 250                 255     


Val Ala Arg Gly Gln Asp Pro Pro Ser Gly Asp Arg Leu Ser Ser Leu 
            260                 265                 270         


Arg Arg Leu Gly Leu Val Tyr Phe Leu Tyr Leu Phe Leu Phe Ser Gly 
        275                 280                 285             


Leu Glu Tyr Thr Leu Ser Phe Leu Thr His Gln Arg Phe Gln Phe Ser 
    290                 295                 300                 


Ser Leu Gln Gln Gly Lys Met Phe Phe Leu Ile Gly Leu Thr Met Ala 
305                 310                 315                 320 


Thr Ile Gln Gly Ala Tyr Ala Arg Arg Ile His Pro Gly Gly Glu Val 
                325                 330                 335     


Ala Ala Val Lys Arg Ala Leu Leu Leu Leu Val Pro Ala Phe Leu Leu 
            340                 345                 350         


Ile Gly Trp Gly Arg Ser Leu Pro Val Leu Gly Leu Gly Leu Leu Leu 
        355                 360                 365             


Tyr Ser Phe Ala Ala Ala Val Val Val Pro Cys Leu Ser Ser Val Val 
    370                 375                 380                 


Ala Gly Tyr Gly Ser Pro Gly Gln Lys Gly Thr Val Met Gly Thr Leu 
385                 390                 395                 400 


Arg Ser Leu Gly Ala Leu Ala Arg Ala Ala Gly Pro Leu Val Ala Ala 
                405                 410                 415     


Ser Val Tyr Trp Leu Ala Gly Ala Gln Ala Cys Phe Thr Thr Trp Ser 
            420                 425                 430         


Gly Leu Phe Leu Leu Pro Phe Phe Leu Leu Gln Lys Leu Ser Tyr Pro 
        435                 440                 445             


Ala Gln Thr Leu Lys Ala Glu 
    450                 455 


<210>  1902
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  1902

Met Ala Ser Thr Ala Val Gln Leu Leu Gly Phe Leu Leu Ser Phe Leu 
1               5                   10                  15      


Gly Met Val Gly Thr Leu Ile Thr Thr Ile Leu Pro His Trp Arg Arg 
            20                  25                  30          


Thr Ala His Val Gly Thr Asn Ile Leu Thr Ala Val Ser Tyr Leu Lys 
        35                  40                  45              


Gly Leu Trp Met Glu Cys Val Trp His Ser Thr Gly Ile Tyr Gln Cys 
    50                  55                  60                  


Gln Ile Tyr Arg Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala 
65                  70                  75                  80  


Arg Ala Leu Met Val Ile Ser Cys Leu Leu Ser Gly Ile Ala Cys Ala 
                85                  90                  95      


Cys Ala Val Ile Gly Met Lys Cys Thr Arg Cys Ala Lys Gly Thr Pro 
            100                 105                 110         


Ala Lys Thr Thr Phe Ala Ile Leu Gly Gly Thr Leu Phe Ile Leu Ala 
        115                 120                 125             


Gly Leu Leu Cys Met Val Ala Val Ser Trp Thr Thr Asn Asp Val Val 
    130                 135                 140                 


Gln Asn Phe Tyr Asn Pro Leu Leu Pro Ser Gly Met Lys Phe Glu Ile 
145                 150                 155                 160 


Gly Gln Ala Leu Tyr Leu Gly Phe Ile Ser Ser Ser Leu Ser Leu Ile 
                165                 170                 175     


Gly Gly Thr Leu Leu Cys Leu Ser Cys Gln Asp Glu Ala Pro Tyr Arg 
            180                 185                 190         


Pro Tyr Gln Ala Pro Pro Arg Ala Thr Thr Thr Thr Ala Asn Thr Ala 
        195                 200                 205             


Pro Ala Tyr Gln Pro Pro Ala Ala Tyr Lys Asp Asn Arg Ala Pro Ser 
    210                 215                 220                 


Val Thr Ser Ala Thr His Ser Gly Tyr Arg Leu Asn Asp Tyr Val 
225                 230                 235                 


<210>  1903
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  1903

Met Ala Ser Thr Ala Val Gln Leu Leu Gly Phe Leu Leu Ser Phe Leu 
1               5                   10                  15      


Gly Met Val Gly Thr Leu Ile Thr Thr Ile Leu Pro His Trp Arg Arg 
            20                  25                  30          


Thr Ala His Val Gly Thr Asn Ile Leu Thr Ala Val Ser Tyr Leu Lys 
        35                  40                  45              


Gly Leu Trp Met Glu Cys Val Trp His Ser Thr Gly Ile Tyr Gln Cys 
    50                  55                  60                  


Gln Ile Tyr Arg Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala 
65                  70                  75                  80  


Arg Ala Leu Met Val Ile Ser Cys Leu Leu Ser Gly Ile Ala Cys Ala 
                85                  90                  95      


Cys Ala Val Ile Gly Met Lys Cys Thr Arg Cys Ala Lys Gly Thr Pro 
            100                 105                 110         


Ala Lys Thr Thr Phe Ala Ile Leu Gly Gly Thr Leu Phe Ile Leu Ala 
        115                 120                 125             


Gly Leu Leu Cys Met Val Ala Val Ser Trp Thr Thr Asn Asp Val Val 
    130                 135                 140                 


Gln Asn Phe Tyr Asn Pro Leu Leu Pro Ser Gly Met Lys Phe Glu Ile 
145                 150                 155                 160 


Gly Gln Ala Leu Tyr Leu Gly Phe Ile Ser Ser Ser Leu Ser Leu Ile 
                165                 170                 175     


Gly Gly Thr Leu Leu Cys Leu Ser Cys Gln Asp Glu Ala Pro Tyr Arg 
            180                 185                 190         


Pro Tyr Gln Ala Pro Pro Arg Ala Thr Thr Thr Thr Ala Asn Thr Ala 
        195                 200                 205             


Pro Ala Tyr Gln Pro Pro Ala Ala Tyr Lys Asp Asn Arg Ala Pro Ser 
    210                 215                 220                 


Val Thr Ser Ala Thr His Ser Gly Tyr Arg Leu Asn Asp Tyr Val 
225                 230                 235                 


<210>  1904
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  1904

Met Ala Ser Thr Ala Val Gln Leu Leu Gly Phe Leu Leu Ser Phe Leu 
1               5                   10                  15      


Gly Met Val Gly Thr Leu Ile Thr Thr Ile Leu Pro His Trp Arg Arg 
            20                  25                  30          


Thr Ala His Val Gly Thr Asn Ile Leu Thr Ala Val Ser Tyr Leu Lys 
        35                  40                  45              


Gly Leu Trp Met Glu Cys Val Trp His Ser Thr Gly Ile Tyr Gln Cys 
    50                  55                  60                  


Gln Ile Tyr Arg Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala 
65                  70                  75                  80  


Arg Ala Leu Met Val Ile Ser Cys Leu Leu Ser Gly Ile Ala Cys Ala 
                85                  90                  95      


Cys Ala Val Ile Gly Met Lys Cys Thr Arg Cys Ala Lys Gly Thr Pro 
            100                 105                 110         


Ala Lys Thr Thr Phe Ala Ile Leu Gly Gly Thr Leu Phe Ile Leu Ala 
        115                 120                 125             


Gly Leu Leu Cys Met Val Ala Val Ser Trp Thr Thr Asn Asp Val Val 
    130                 135                 140                 


Gln Asn Phe Tyr Asn Pro Leu Leu Pro Ser Gly Met Lys Phe Glu Ile 
145                 150                 155                 160 


Gly Gln Ala Leu Tyr Leu Gly Phe Ile Ser Ser Ser Leu Ser Leu Ile 
                165                 170                 175     


Gly Gly Thr Leu Leu Cys Leu Ser Cys Gln Asp Glu Ala Pro Tyr Arg 
            180                 185                 190         


Pro Tyr Gln Ala Pro Pro Arg Ala Thr Thr Thr Thr Ala Asn Thr Ala 
        195                 200                 205             


Pro Ala Tyr Gln Pro Pro Ala Ala Tyr Lys Asp Asn Arg Ala Pro Ser 
    210                 215                 220                 


Val Thr Ser Ala Thr His Ser Gly Tyr Arg Leu Asn Asp Tyr Val 
225                 230                 235                 


<210>  1905
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  1905

Met Ser Pro Glu Glu Trp Thr Tyr Leu Val Val Leu Leu Ile Ser Ile 
1               5                   10                  15      


Pro Ile Gly Phe Leu Phe Lys Lys Ala Gly Pro Gly Leu Lys Arg Trp 
            20                  25                  30          


Gly Ala Ala Ala Val Gly Leu Gly Leu Thr Leu Phe Thr Cys Gly Pro 
        35                  40                  45              


His Thr Leu His Ser Leu Val Thr Ile Leu Gly Thr Trp Ala Leu Ile 
    50                  55                  60                  


Gln Ala Gln Pro Cys Ser Cys His Ala Leu Ala Leu Ala Trp Thr Phe 
65                  70                  75                  80  


Ser Tyr Leu Leu Phe Phe Arg Ala Leu Ser Leu Leu Gly Leu Pro Thr 
                85                  90                  95      


Pro Thr Pro Phe Thr Asn Ala Val Gln Leu Leu Leu Thr Leu Lys Leu 
            100                 105                 110         


Val Ser Leu Ala Ser Glu Val Gln Asp Leu His Leu Ala Gln Arg Lys 
        115                 120                 125             


Glu Met Ala Ser Gly Phe Ser Lys Gly Pro Thr Leu Gly Leu Leu Pro 
    130                 135                 140                 


Asp Val Pro Ser Leu Met Glu Thr Leu Ser Tyr Ser Tyr Cys Tyr Val 
145                 150                 155                 160 


Gly Ile Met Thr Gly Pro Phe Phe Arg Tyr Arg Thr Tyr Leu Asp Trp 
                165                 170                 175     


Leu Glu Gln Pro Phe Pro Gly Ala Val Pro Ser Leu Arg Pro Leu Leu 
            180                 185                 190         


Arg Arg Ala Trp Pro Ala Pro Leu Phe Gly Leu Leu Phe Leu Leu Ser 
        195                 200                 205             


Ser His Leu Phe Pro Leu Glu Ala Val Arg Glu Asp Ala Phe Tyr Ala 
    210                 215                 220                 


Arg Pro Leu Pro Ala Arg Leu Phe Tyr Met Ile Pro Val Phe Phe Ala 
225                 230                 235                 240 


Phe Arg Met Arg Phe Tyr Val Ala Trp Ile Ala Ala Glu Cys Gly Cys 
                245                 250                 255     


Ile Ala Ala Gly Phe Gly Ala Tyr Pro Val Ala Ala Lys Ala Arg Ala 
            260                 265                 270         


Gly Gly Gly Pro Thr Leu Gln Cys Pro Pro Pro Ser Ser Pro Glu Lys 
        275                 280                 285             


Ala Ala Ser Leu Glu Tyr Asp Tyr Glu Thr Ile Arg Asn Ile Asp Cys 
    290                 295                 300                 


Tyr Ser Thr Asp Phe Cys Val Arg Val Arg Asp Gly Met Arg Tyr Trp 
305                 310                 315                 320 


Asn Met Thr Val Gln Trp Trp Leu Ala Gln Tyr Ile Tyr Lys Ser Ala 
                325                 330                 335     


Pro Ala Arg Ser Tyr Val Leu Arg 
            340                 


<210>  1906
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  1906

Met Gly Ser Ser Arg Cys Gly Pro Gly Ala His Pro Val His Leu Trp 
1               5                   10                  15      


Pro Pro His Phe Ala Phe Ser Gly His His Pro Arg Asp Leu Gly Pro 
            20                  25                  30          


His Ser Gly Pro Ala Leu Leu Val Ser Leu Ala Ser Glu Val Gln Asp 
        35                  40                  45              


Leu His Leu Ala Gln Arg Lys Glu Met Ala Ser Gly Phe Ser Lys Gly 
    50                  55                  60                  


Pro Thr Leu Gly Leu Leu Pro Asp Val Pro Ser Leu Met Glu Thr Leu 
65                  70                  75                  80  


Ser Tyr Ser Tyr Cys Tyr Val Gly Ile Met Thr Gly Pro Phe Phe Arg 
                85                  90                  95      


Tyr Arg Thr Tyr Leu Asp Trp Leu Glu Gln Pro Phe Pro Gly Ala Val 
            100                 105                 110         


Pro Ser Leu Arg Pro Leu Leu Arg Arg Ala Trp Pro Ala Pro Leu Phe 
        115                 120                 125             


Gly Leu Leu Phe Leu Leu Ser Ser His Leu Phe Pro Leu Glu Ala Val 
    130                 135                 140                 


Arg Glu Asp Ala Phe Tyr Ala Arg Pro Leu Pro Ala Arg Leu Phe Tyr 
145                 150                 155                 160 


Met Ile Pro Val Phe Phe Ala Phe Arg Met Arg Phe Tyr Val Ala Trp 
                165                 170                 175     


Ile Ala Ala Glu Cys Gly Cys Ile Ala Ala Gly Phe Gly Ala Tyr Pro 
            180                 185                 190         


Val Ala Ala Lys Ala Arg Ala Gly Gly Gly Pro Thr Leu Gln Cys Pro 
        195                 200                 205             


Pro Pro Ser Ser Pro Glu Lys Ala Ala Ser Leu Glu Tyr Asp Tyr Glu 
    210                 215                 220                 


Thr Ile Arg Asn Ile Asp Cys Tyr Ser Thr Asp Phe Cys Val Arg Val 
225                 230                 235                 240 


Arg Asp Gly Met Arg Tyr Trp Asn Met Thr Val Gln Trp Trp Leu Ala 
                245                 250                 255     


Gln Tyr Ile Tyr Lys Ser Ala Pro Ala Arg Ser Tyr Val Leu Arg Ser 
            260                 265                 270         


Ala Trp Thr Met Leu Leu Ser Ala Tyr Trp His Gly Leu His Pro Gly 
        275                 280                 285             


Tyr Tyr Leu Ser Phe Leu Thr Ile Pro Leu Cys Leu Ala Ala Glu Gly 
    290                 295                 300                 


Arg Leu Glu Ser Ala Leu Arg Gly Arg Leu Ser Pro Gly Gly Gln Lys 
305                 310                 315                 320 


Ala Trp Asp Trp Val His Trp Phe Leu Lys Met Arg Ala Tyr Asp Tyr 
                325                 330                 335     


Met Cys Met Gly Phe Val Leu Leu Ser Leu Ala Asp Thr Leu Arg Tyr 
            340                 345                 350         


Trp Ala Ser Ile Tyr Phe Cys Ile His Phe Leu Ala Leu Ala Ala Leu 
        355                 360                 365             


Gly Leu Gly Leu Ala Leu Gly Gly Gly Ser Pro Ser Arg Arg Lys Ala 
    370                 375                 380                 


Ala Ser Gln Pro Thr Ser Leu Ala Pro Glu Lys Leu Arg Glu Glu 
385                 390                 395                 


<210>  1907
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  1907

Met Leu Met Ala Ser Thr Thr Ser Ala Val Pro Gly His Pro Ser Leu 
1               5                   10                  15      


Pro Ser Leu Pro Ser Asn Ser Ser Gln Glu Arg Pro Leu Asp Thr Arg 
            20                  25                  30          


Asp Pro Leu Leu Ala Arg Ala Glu Leu Ala Leu Leu Ser Ile Val Phe 
        35                  40                  45              


Val Ala Val Ala Leu Ser Asn Gly Leu Val Leu Ala Ala Leu Ala Arg 
    50                  55                  60                  


Arg Gly Arg Arg Gly His Trp Ala Pro Ile His Val Phe Ile Gly His 
65                  70                  75                  80  


Leu Cys Leu Ala Asp Leu Ala Val Ala Leu Phe Gln Val Leu Pro Gln 
                85                  90                  95      


Leu Ala Trp Lys Ala Thr Asp Arg Phe Arg Gly Pro Asp Ala Leu Cys 
            100                 105                 110         


Arg Ala Val Lys Tyr Leu Gln Met Val Gly Met Tyr Ala Ser Ser Tyr 
        115                 120                 125             


Met Ile Leu Ala Met Thr Leu Asp Arg His Arg Ala Ile Cys Arg Pro 
    130                 135                 140                 


Met Leu Ala Tyr Arg His Gly Ser Gly Ala His Trp Asn Arg Pro Val 
145                 150                 155                 160 


Leu Val Ala Trp Ala Phe Ser Leu Leu Leu Ser Leu Pro Gln Leu Phe 
                165                 170                 175     


Ile Phe Ala Gln Arg Asn Val Glu Gly Gly Ser Gly Val Thr Asp Cys 
            180                 185                 190         


Trp Ala Cys Phe Ala Glu Pro Trp Gly Arg Arg Thr Tyr Val Thr Trp 
        195                 200                 205             


Ile Ala Leu Met Val Phe Val Ala Pro Thr Leu Gly Ile Ala Ala Cys 
    210                 215                 220                 


Gln Val Leu Ile Phe Arg Glu Ile His Ala Ser Leu Val Pro Gly Pro 
225                 230                 235                 240 


Ser Glu Arg Pro Gly Gly Arg Arg Arg Gly Arg Arg Thr Gly Ser Pro 
                245                 250                 255     


Gly Glu Gly Ala His Val Ser Ala Ala Val Ala Lys Thr Val Arg Met 
            260                 265                 270         


Thr Leu Val Ile Val Val Val Tyr Val Leu Cys Trp Ala Pro Phe Phe 
        275                 280                 285             


Leu Val Gln Leu Trp Ala Ala Trp Asp Pro Glu Ala Pro Leu Glu Gly 
    290                 295                 300                 


Gly Cys Ser Arg Gly 
305                 


<210>  1908
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  1908

Met Val Gly Lys Thr Phe Thr Tyr Leu Leu Gly Ser Asp Ala Ala Ala 
1               5                   10                  15      


Leu Leu Phe Asn Ser Lys Asn Glu Asp Leu Asn Ala Glu Asp Val Tyr 
            20                  25                  30          


Ser Arg Leu Thr Thr Pro Val Phe Gly Lys Gly Val Ala Tyr Asp Val 
        35                  40                  45              


Pro Asn Pro Val Phe Leu Glu Gln Lys Lys Met Leu Lys Ser Gly Leu 
    50                  55                  60                  


Asn Ile Ala His Phe Lys Gln His Val Ser Ile Ile Glu Lys Glu Thr 
65                  70                  75                  80  


Lys Glu Tyr Phe Glu Ser Trp Gly Glu Ser Gly Glu Lys Asn Val Phe 
                85                  90                  95      


Glu Ala Leu Ser Glu Leu Ile Ile Leu Thr Ala Ser His Cys Leu His 
            100                 105                 110         


Gly Lys Glu Ile Arg Ser Gln Leu Asn Glu Lys Val Ala Gln Leu Tyr 
        115                 120                 125             


Ala Asp Leu Asp Gly Gly Phe Ser His Ala Ala Trp Leu Leu Pro Gly 
    130                 135                 140                 


Trp Leu Pro Leu Pro Ser Phe Arg Arg Arg Asp Arg Ala His Arg Glu 
145                 150                 155                 160 


Ile Lys Asp Ile Phe Tyr Lys Ala Ile Gln Lys Arg Arg Gln Ser Gln 
                165                 170                 175     


Glu Lys Ile Asp Asp Ile Leu Gln Thr Leu Leu Asp Ala Thr Tyr Lys 
            180                 185                 190         


Asp Gly Arg Pro Leu Thr Asp Asp Glu Val Ala Gly Met Leu Ile Gly 
        195                 200                 205             


Leu Leu Leu Ala Gly Gln His Thr Ser Ser Thr Thr Ser Ala Trp Met 
    210                 215                 220                 


Gly Phe Phe Leu Ala Arg Asp Lys Thr Leu Gln Lys Lys Cys Tyr Leu 
225                 230                 235                 240 


Glu Gln Lys Thr Val Cys Gly Glu Asn Leu Pro Pro Leu Thr Tyr Asp 
                245                 250                 255     


Gln Leu Lys Asp Leu Asn Leu Leu Asp Arg Cys Ile Lys Glu Thr Leu 
            260                 265                 270         


Arg Leu Arg Pro Pro Ile Met Ile Met Met Arg Met Ala Arg Thr Pro 
        275                 280                 285             


Gln Thr Val Ala Gly Tyr Thr Ile Pro Pro Gly His Gln Val Cys Val 
    290                 295                 300                 


Ser Pro Thr Val Asn Gln Arg Leu Lys Asp Ser Trp Val Glu Arg Leu 
305                 310                 315                 320 


Asp Phe Asn Pro Asp Arg Tyr Leu Gln Asp Asn Pro Ala Ser Gly Glu 
                325                 330                 335     


Lys Phe Ala Tyr Val Pro Phe Gly Ala Gly Arg His Arg Cys Ile Gly 
            340                 345                 350         


Glu Asn Phe Ala Tyr Val Gln Ile Lys Thr Ile Trp Ser Thr Met Leu 
        355                 360                 365             


Arg Leu Tyr Glu Phe Asp Leu Ile Asp Gly Tyr Phe Pro Thr Val Asn 
    370                 375                 380                 


Tyr Thr Thr Met Ile His Thr Pro Glu Asn Pro Val Ile Arg Tyr Lys 
385                 390                 395                 400 


Arg Arg Ser Lys 
                


<210>  1909
<211>  731
<212>  PRT
<213>  Homo sapiens

<400>  1909

Met Lys Thr Arg Ser Pro Lys Pro Leu Leu Thr Gly Leu Met Trp Ala 
1               5                   10                  15      


Gln Gln Gly Thr Thr Pro Gly Thr Pro Lys Leu Arg His Thr Cys Glu 
            20                  25                  30          


Gln Gly Asp Gly Val Gly Pro Tyr Gly Trp Glu Phe His Asp Gly Leu 
        35                  40                  45              


Ser Phe Gly Arg Gln His Ile Gln Asp Gly Ala Leu Arg Leu Thr Thr 
    50                  55                  60                  


Glu Phe Val Lys Arg Pro Gly Gly Gln His Gly Gly Asp Trp Ser Trp 
65                  70                  75                  80  


Arg Val Thr Val Glu Pro Gln Asp Ser Gly Thr Ser Ala Leu Pro Leu 
                85                  90                  95      


Val Ser Leu Phe Phe Tyr Val Val Thr Asp Gly Lys Glu Val Leu Leu 
            100                 105                 110         


Pro Glu Val Gly Ala Lys Gly Gln Leu Lys Phe Ile Ser Gly His Thr 
        115                 120                 125             


Ser Glu Leu Gly Asp Phe Arg Phe Thr Leu Leu Pro Pro Thr Ser Pro 
    130                 135                 140                 


Gly Asp Thr Ala Pro Lys Tyr Gly Ser Tyr Asn Val Phe Trp Thr Ser 
145                 150                 155                 160 


Asn Pro Gly Leu Pro Leu Leu Thr Glu Met Val Lys Ser Arg Leu Asn 
                165                 170                 175     


Ser Trp Phe Gln His Arg Pro Pro Gly Ala Pro Pro Glu Arg Tyr Leu 
            180                 185                 190         


Gly Leu Pro Gly Ser Leu Lys Trp Glu Asp Arg Gly Pro Ser Gly Gln 
        195                 200                 205             


Gly Gln Gly Gln Phe Leu Ile Gln Gln Val Thr Leu Lys Ile Pro Ile 
    210                 215                 220                 


Ser Ile Glu Phe Val Phe Glu Ser Gly Ser Ala Gln Ala Gly Gly Asn 
225                 230                 235                 240 


Gln Ala Leu Pro Arg Leu Ala Gly Ser Leu Leu Thr Gln Ala Leu Glu 
                245                 250                 255     


Ser His Ala Glu Gly Phe Arg Glu Arg Phe Glu Lys Thr Phe Gln Leu 
            260                 265                 270         


Lys Glu Lys Gly Leu Ser Ser Gly Glu Gln Val Leu Gly Gln Ala Ala 
        275                 280                 285             


Leu Ser Gly Leu Leu Gly Gly Ile Gly Tyr Phe Tyr Gly Gln Gly Leu 
    290                 295                 300                 


Val Leu Pro Asp Ile Gly Val Glu Gly Ser Glu Gln Lys Val Asp Pro 
305                 310                 315                 320 


Ala Leu Phe Pro Pro Val Pro Leu Phe Thr Ala Val Pro Ser Arg Ser 
                325                 330                 335     


Phe Phe Pro Arg Gly Phe Leu Trp Asp Glu Gly Phe His Gln Leu Val 
            340                 345                 350         


Val Gln Arg Trp Asp Pro Ser Leu Thr Arg Glu Ala Leu Gly His Trp 
        355                 360                 365             


Leu Gly Leu Leu Asn Ala Asp Gly Trp Ile Gly Arg Glu Gln Ile Leu 
    370                 375                 380                 


Gly Asp Glu Ala Arg Ala Arg Val Pro Pro Glu Phe Leu Val Gln Arg 
385                 390                 395                 400 


Ala Val His Ala Asn Pro Pro Thr Leu Leu Leu Pro Val Ala His Met 
                405                 410                 415     


Leu Glu Val Gly Asp Pro Asp Asp Leu Ala Phe Leu Arg Lys Ala Leu 
            420                 425                 430         


Pro Arg Leu His Ala Trp Phe Ser Trp Leu His Gln Ser Gln Ala Gly 
        435                 440                 445             


Pro Leu Pro Leu Ser Tyr Arg Trp Arg Gly Arg Asp Pro Ala Leu Pro 
    450                 455                 460                 


Thr Leu Leu Asn Pro Lys Thr Leu Pro Ser Gly Leu Asp Asp Tyr Pro 
465                 470                 475                 480 


Arg Ala Ser His Pro Ser Val Thr Glu Arg His Leu Asp Leu Arg Cys 
                485                 490                 495     


Trp Val Ala Leu Gly Ala Arg Val Leu Thr Arg Leu Ala Glu His Leu 
            500                 505                 510         


Gly Glu Ala Glu Val Ala Ala Glu Leu Gly Pro Leu Ala Ala Ser Leu 
        515                 520                 525             


Glu Ala Ala Glu Ser Leu Asp Glu Leu His Trp Ala Pro Glu Leu Gly 
    530                 535                 540                 


Val Phe Ala Asp Phe Gly Asn His Thr Lys Ala Val Gln Leu Lys Pro 
545                 550                 555                 560 


Arg Pro Pro Gln Gly Leu Val Arg Val Val Gly Arg Pro Gln Pro Gln 
                565                 570                 575     


Leu Gln Tyr Val Asp Ala Leu Gly Tyr Val Ser Leu Phe Pro Leu Leu 
            580                 585                 590         


Leu Arg Leu Leu Asp Pro Thr Ser Ser Arg Leu Gly Pro Leu Leu Asp 
        595                 600                 605             


Ile Leu Ala Asp Ser Arg His Leu Trp Ser Pro Phe Gly Leu Arg Ser 
    610                 615                 620                 


Leu Ala Ala Ser Ser Ser Phe Tyr Gly Gln Arg Asn Ser Glu His Asp 
625                 630                 635                 640 


Pro Pro Tyr Trp Arg Gly Ala Val Trp Leu Asn Val Asn Tyr Leu Ala 
                645                 650                 655     


Leu Gly Ala Leu His His Tyr Gly His Leu Glu Gly Pro His Gln Ala 
            660                 665                 670         


Arg Ala Ala Lys Leu His Gly Glu Leu Arg Ala Asn Val Val Gly Asn 
        675                 680                 685             


Val Trp Arg Gln Tyr Gln Ala Thr Gly Phe Leu Trp Glu Gln Tyr Ser 
    690                 695                 700                 


Asp Arg Asp Gly Arg Gly Met Gly Cys Arg Pro Phe His Gly Trp Thr 
705                 710                 715                 720 


Ser Leu Val Leu Leu Ala Met Ala Glu Asp Tyr 
                725                 730     


<210>  1910
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  1910

Met Cys Ala Phe Pro Trp Leu Leu Leu Leu Leu Leu Leu Gln Glu Gly 
1               5                   10                  15      


Ser Gln Arg Arg Leu Trp Arg Trp Cys Gly Ser Glu Glu Val Val Ala 
            20                  25                  30          


Val Leu Gln Glu Ser Ile Ser Leu Pro Leu Glu Ile Pro Pro Asp Glu 
        35                  40                  45              


Glu Val Glu Asn Ile Ile Trp Ser Ser His Lys Ser Leu Ala Thr Val 
    50                  55                  60                  


Val Pro Gly Lys Glu Gly His Pro Ala Thr Ile Met Val Thr Asn Pro 
65                  70                  75                  80  


His Tyr Gln Gly Gln Val Ser Phe Leu Asp Pro Ser Tyr Ser Leu His 
                85                  90                  95      


Ile Ser Asn Leu Ser Trp Glu Asp Ser Gly Leu Tyr Gln Ala Gln Val 
            100                 105                 110         


Asn Leu Arg Thr Ser Gln Ile Ser Thr Met Gln Gln Tyr Asn Ile Cys 
        115                 120                 125             


Val Tyr His Pro Asn Tyr Ala Ser Glu Lys Pro Ser Thr Ala Phe Cys 
    130                 135                 140                 


Leu Leu Ala Lys Gly Leu Leu Ile Phe Leu Leu Leu Val Ile Leu Ala 
145                 150                 155                 160 


Met Gly Leu Trp Val Ile Arg Val Gln Lys Arg His Lys Met Pro Arg 
                165                 170                 175     


Met Lys Lys Leu Met Arg Asn Arg Met Lys Leu Arg Lys Glu Ala Lys 
            180                 185                 190         


Pro Gly Ser Ser Pro Ala 
        195             


<210>  1911
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  1911

Met Cys Ala Phe Pro Trp Leu Leu Leu Leu Leu Leu Leu Gln Glu Gly 
1               5                   10                  15      


Ser Gln Arg Arg Leu Trp Arg Trp Cys Gly Ser Glu Glu Val Val Ala 
            20                  25                  30          


Val Leu Gln Glu Ser Ile Ser Leu Pro Leu Glu Ile Pro Pro Asp Glu 
        35                  40                  45              


Glu Val Glu Asn Ile Ile Trp Ser Ser His Lys Ser Leu Ala Thr Val 
    50                  55                  60                  


Val Pro Gly Lys Glu Gly His Pro Ala Thr Ile Met Val Thr Asn Pro 
65                  70                  75                  80  


His Tyr Gln Gly Gln Ile Leu Thr Met Leu Leu Arg Ser Leu Gln Gln 
                85                  90                  95      


Pro Ser Ala Ser Trp Pro Arg Asp Cys Ser Ser Ser Cys Ser Trp 
            100                 105                 110     


<210>  1912
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  1912

Met Ala Ala Ser Ala Gly Ala Gly Ala Val Ile Ala Ala Pro Asp Ser 
1               5                   10                  15      


Arg Arg Trp Leu Trp Ser Val Leu Ala Ala Ala Leu Gly Leu Leu Thr 
            20                  25                  30          


Ala Gly Val Ser Ala Leu Glu Val Tyr Thr Pro Lys Glu Ile Phe Val 
        35                  40                  45              


Ala Asn Gly Thr Gln Gly Lys Leu Thr Cys Lys Phe Lys Ser Thr Ser 
    50                  55                  60                  


Thr Thr Gly Gly Leu Thr Ser Val Ser Trp Ser Phe Gln Pro Glu Gly 
65                  70                  75                  80  


Ala Asp Thr Thr Val Ser Gly Pro Val Ile Tyr Ala Gln Leu Asp His 
                85                  90                  95      


Ser Gly Gly His His Ser Asp Lys Ile Asn Lys Ser Glu Ser Val Val 
            100                 105                 110         


Tyr Ala Asp Ile Arg Lys Asn 
        115                 


<210>  1913
<211>  7081
<212>  PRT
<213>  Homo sapiens

<400>  1913

Met Ser Lys Gln Tyr Tyr Ser Phe Lys Lys Gly Val Gly Ser Gly Leu 
1               5                   10                  15      


Glu Asp Asn Thr Phe Met Thr Leu Trp Asp Phe Leu Glu Ser Trp Ile 
            20                  25                  30          


Ile Gln Asn Asp Trp Val Ala Ile Phe Phe Ile Ile Leu Leu Gly Ile 
        35                  40                  45              


Ile Phe Glu Ile Ile Leu Met Lys Ala Cys Ala Ser Phe Trp Lys Lys 
    50                  55                  60                  


Pro Thr Leu Pro Glu Lys Gly Ser Ser Asp Val Gln Glu Thr Glu Asp 
65                  70                  75                  80  


Ser Cys Pro Lys Ser Arg Lys Leu Ala Pro Glu Asn Trp Ser Val Ile 
                85                  90                  95      


Asn Ser Ser Ser Gly Glu Arg Val Gly Thr Phe Leu Glu Lys Arg Ile 
            100                 105                 110         


Thr Ser Ser Leu Thr Ser Glu Glu Lys Glu Cys Asn Phe Glu Asp Arg 
        115                 120                 125             


Ile Leu Phe Ser Arg Glu Ile Leu Trp Ser Gly Thr Ser Glu Ser Glu 
    130                 135                 140                 


Asp Gln Val Ser Pro Ser Ser Glu Ser His Val Pro Ser Ser Asn Gly 
145                 150                 155                 160 


Ile Ser Ser Ser Leu Pro Leu Phe Tyr Ser Glu Val Glu Glu Thr Cys 
                165                 170                 175     


Leu Ser His Thr Glu His Pro Asp Arg Glu Tyr Glu Thr Ile Gln Phe 
            180                 185                 190         


Ser Ser Lys Lys Leu Phe Ser Met Met Lys Thr Asn Lys Asn Lys Asn 
        195                 200                 205             


Ser Gly Phe Ser Ser Asp Leu Ser Phe Ser Ala Ser Arg Phe Thr Val 
    210                 215                 220                 


Glu Asn Glu Asp Leu Asp Val Ala Pro Cys Pro Leu Ala His Leu Phe 
225                 230                 235                 240 


Leu Ser Arg Asp Gln Val Arg Leu Leu Glu Glu Asn Val Arg Asn Gln 
                245                 250                 255     


Ile Pro Ser Lys Pro Lys Thr Lys Leu Gly Ser Arg Thr Thr Tyr Gln 
            260                 265                 270         


Cys Ser Arg Ser Gln Glu Ser Leu Asn Gln Asn Gln Pro Ser Val Gly 
        275                 280                 285             


Met Val Ile Ser Val Gln Ala Gln Asp Ser Phe Pro Gly Gln Asn Ala 
    290                 295                 300                 


Phe Gln Asn Gln Gly Leu Tyr Glu Val Gln Phe Thr Ser Gln Ala Gln 
305                 310                 315                 320 


Tyr Ile Asn His Asn Gln Glu Ser Ile Lys Ser Gln Pro Glu Ser Lys 
                325                 330                 335     


Ala Ser Asn Phe Ala Gln Pro Glu Asp Val Met Lys Lys Pro Phe Ser 
            340                 345                 350         


Ser Ser Thr Gln Asp Ser Phe Gln Ser Gln Asp Leu Asp Arg Asn Gln 
        355                 360                 365             


His Phe Val Glu Val Pro Ser Ile Val Glu Ala Lys Tyr Ser Val Lys 
    370                 375                 380                 


Gly Leu Glu Ser Asp Glu His Leu Gly Glu Asp Gln His Cys Val Trp 
385                 390                 395                 400 


Phe Ile Asp Ser Asn Lys Val Lys Tyr Ser Ile Lys Gly Gln Asp Thr 
                405                 410                 415     


Ile Phe Lys Asn Ala Glu Phe Leu Val Leu Thr Leu Asn Pro Asn Leu 
            420                 425                 430         


Val Thr Glu Asp Met Pro Gln Leu Arg Ser Val Lys Ala Gln Gly Gln 
        435                 440                 445             


Gln Gln Ile Val Ser Ser Glu Leu Asn Gln Asp Ser Val Tyr Ser Ser 
    450                 455                 460                 


Val Pro Leu Leu Ser Thr Ile Lys Gly Gln Lys Asn Arg Arg Lys Thr 
465                 470                 475                 480 


Pro Asp Ser Lys Ser Lys Leu Ser Leu Asn Val Pro Ser Leu Lys Ala 
                485                 490                 495     


Lys Lys Thr Pro Thr Ser Gln Val Phe Gln Ile Thr Val Cys His Thr 
            500                 505                 510         


Leu Lys Asn Arg Asn Glu Leu Gly Cys Lys Asn Asn Thr Glu Lys Lys 
        515                 520                 525             


Glu Leu His Glu Arg Lys Asp Ile Ser Asp Ile Ala Leu His Leu Ile 
    530                 535                 540                 


Ser Val Ser Lys Leu Ile Leu Pro Tyr Val Lys Asn Tyr Ser Arg Lys 
545                 550                 555                 560 


Gln Leu Val Lys Val Met Pro Gly Leu Ile Lys Cys Gly His Phe Leu 
                565                 570                 575     


Gln Lys Gln Asn Lys Ser Pro Asp Thr Glu Lys Ile Asn Tyr Ala Gly 
            580                 585                 590         


Pro Leu Glu Glu Thr Gly Ile Ser Asp Ile Thr Lys Lys Glu Lys Glu 
        595                 600                 605             


Tyr Asp Lys Glu Asn Lys Arg Leu Lys Asn Ile Ser Pro Lys Met Leu 
    610                 615                 620                 


Pro Gln Leu Glu Gln Ser Phe Met Val Asn Thr Val Gln Leu Lys Ala 
625                 630                 635                 640 


Pro Cys Leu Leu Val Glu Thr Asn Gly Lys Ser Lys Glu Ser Leu Lys 
                645                 650                 655     


Asp Ser Ile Thr Gln Ala Lys Gly Ile Gly Ile Thr Glu Phe His Val 
            660                 665                 670         


Leu Asn Ser Lys Lys Pro Phe Asp Leu His Ile Pro Lys His Lys Thr 
        675                 680                 685             


Ser Leu Glu Glu Ala Ile Ser Lys Pro Met Gln Lys Leu Val Ser Ser 
    690                 695                 700                 


Pro Glu Met Glu Ser Asn Asn Arg Met Lys Ile Gln Glu Asp Leu Gln 
705                 710                 715                 720 


Ser Ser Glu Asn Ser His Leu Gln Leu Ser Asn Gly Glu Glu Leu Pro 
                725                 730                 735     


Thr Ser Thr Pro Lys Thr Gln Arg Cys Phe Pro Arg Glu Asn Thr Gln 
            740                 745                 750         


Lys Gln Lys Asp Phe Leu Glu Leu Val Leu Glu Leu Ser Asn Val Gly 
        755                 760                 765             


Leu Leu Ile Ser Pro Gly Ser Lys Met His Lys Ser Ser Glu Glu Leu 
    770                 775                 780                 


Glu Ala Ile Lys Ile Gln Val Asn Thr Glu Ser Val Asn Leu Lys Glu 
785                 790                 795                 800 


Ser Lys Pro Leu Ile Leu Asn Val Thr Glu Asp Ser Asp Leu Arg Glu 
                805                 810                 815     


Ser Glu Glu Leu Glu Cys Asn Thr Gly Ser Asn Ile Thr Asn Met His 
            820                 825                 830         


Gln Asp Lys Glu Thr Ser Asp Ala Phe His Ser Ala Thr Tyr Thr Thr 
        835                 840                 845             


Ile Ser Gln Leu Pro Asp Thr Glu Thr His Ser Ile Ser Lys Ala Lys 
    850                 855                 860                 


Ala Asp Thr Leu Arg Ile Ile Arg Leu Ser His Ser Ala Ser Lys Gln 
865                 870                 875                 880 


Glu Lys Leu Pro Asp Glu Lys Glu Thr Gln Asn Ala Glu Tyr Ile Asp 
                885                 890                 895     


Lys Ser Cys Thr Phe Lys Lys Pro Gln Gln Cys Asp Arg Lys Glu Gln 
            900                 905                 910         


Glu Lys Glu Ala Asn Ser Glu Leu Thr Gln Gly Phe Arg Phe Ser Ile 
        915                 920                 925             


His Leu Lys Gln Lys Pro Lys Tyr Val Lys Phe Gln Met Glu Gln Ile 
    930                 935                 940                 


Ser Ser Gly Ser Ser Lys Ala Pro Asn Lys Glu Gln Glu Val Gln Pro 
945                 950                 955                 960 


Gln Thr Leu Ser Thr Gln Thr Ile Leu Glu Asn Ser Pro Cys Pro Met 
                965                 970                 975     


Met Asp Pro Phe Gln Val Glu Lys Val Lys Gln Ser Thr Asp Arg Pro 
            980                 985                 990         


Thr Asp Arg Glu Ser Ala Gly Asp  Pro Lys Asn Pro Leu  Thr Met Pro 
        995                 1000                 1005             


Glu Asn  Leu Pro Val Gly Glu  Leu Leu Ile Glu Thr  Thr Glu Tyr 
    1010                 1015                 1020             


Ser Val  Pro Phe Gly Gly Asn  Leu Gln Lys Thr Thr  Asp Ser His 
    1025                 1030                 1035             


Ile Ala  Glu Glu Lys Glu Asp  Val Lys Arg Tyr Leu  Pro Ala Val 
    1040                 1045                 1050             


Ala Leu  Gly Ser Phe Asn Asn  His Leu Leu Thr Leu  Pro Tyr Phe 
    1055                 1060                 1065             


Lys Arg  Gln Glu Ile Lys Lys  Lys Leu Ser Glu Thr  Lys Ser Val 
    1070                 1075                 1080             


Leu Ser  Val Lys Tyr Val Ile  Met Lys Val Lys Lys  Pro Ala Ile 
    1085                 1090                 1095             


Ser Leu  Met Pro Tyr Ile Asn  Ile Cys Gly Thr Ser  Asn His Arg 
    1100                 1105                 1110             


Lys Lys  Met Gly Gly Asn Phe  Glu Ile Ile Ile Lys  Gln Ile Leu 
    1115                 1120                 1125             


Gln Asp  Lys Ile Ala Ala Gly  Met Leu Leu Asn Val  Ile Tyr Pro 
    1130                 1135                 1140             


Pro Met  Ser Ile Leu Pro Asn  Thr Arg Met Tyr Ser  Arg Leu Asn 
    1145                 1150                 1155             


Ala Glu  Asn His Ser His Ile  Lys Leu Val Gln Glu  Glu Ser Gln 
    1160                 1165                 1170             


Ile Glu  Arg Glu Glu Lys Tyr  Pro Tyr Phe Ile Asn  Glu Gly Asn 
    1175                 1180                 1185             


Glu Ser  Gln Asn Thr Leu Asp  Ala Lys Leu Gln Asp  Glu Val Lys 
    1190                 1195                 1200             


Gly Val  Lys Glu Thr Leu Pro  Lys Ala Val Leu His  Asp Ser Cys 
    1205                 1210                 1215             


Asn Leu  Gly Leu Asp Ala His  Leu Glu Lys Glu Ile  Lys Thr Glu 
    1220                 1225                 1230             


Lys Glu  Met His Gln Pro Ile  Pro Phe Thr Glu Thr  Ile Ile Glu 
    1235                 1240                 1245             


Ser Val  Val Ser Pro Ile Met  Glu Leu Ser His Ala  Glu Asn Val 
    1250                 1255                 1260             


Lys Ser  Thr Gln Lys Thr Gln  Thr Asp Cys Lys Cys  Thr Ala Asp 
    1265                 1270                 1275             


Ser Glu  Thr Pro Ser Pro Ile  Ser Gly Lys Ser Leu  Ile Gly Asp 
    1280                 1285                 1290             


Pro Leu  Asn Gln Thr Arg Glu  Ser Tyr Ile Pro Ser  Asn Gly Ser 
    1295                 1300                 1305             


Asp Thr  Arg Glu Met Gly Tyr  Cys Phe Ala Glu Glu  Lys Thr Glu 
    1310                 1315                 1320             


Ile Pro  Lys Asp Leu Pro Ala  Thr Ser Pro Glu Thr  Phe Asn Tyr 
    1325                 1330                 1335             


Cys Thr  Pro Val Leu Ser Cys  Ser Lys Val Met Lys  Lys Arg Val 
    1340                 1345                 1350             


Thr Phe  Ala Leu Thr Thr Ser  Thr Ala Lys Pro Lys  Cys Val Asn 
    1355                 1360                 1365             


Thr Lys  Ala Val Lys Pro Ser  Ile Ser Glu Thr Val  Ser Val Thr 
    1370                 1375                 1380             


Ser His  Arg Lys Lys Ser Glu  Leu Asp Phe Lys Thr  Lys Phe Lys 
    1385                 1390                 1395             


Lys Ile  Asn Gln Thr Lys Gly  Leu Val Pro Glu Cys  Leu Asn Thr 
    1400                 1405                 1410             


Leu Cys  Ser Pro Met His Ser  Arg Leu Gln Arg Glu  Phe Cys Leu 
    1415                 1420                 1425             


Pro Ala  Ser Gln Leu Lys Gln  Gly Glu Thr Ala Asp  Lys Thr Tyr 
    1430                 1435                 1440             


Thr Asp  Val Phe Ala Lys Asn  Ser Ile Ser His Asp  Arg Glu Glu 
    1445                 1450                 1455             


Lys Leu  Gln Asp Gly Lys Glu  Glu Glu His Lys Val  Leu Leu Glu 
    1460                 1465                 1470             


Ala Ala  Pro Gln Leu Ser Gln  His Leu Gly Ser Glu  Ala Gly Gln 
    1475                 1480                 1485             


Met Lys  Glu Ile His Leu Glu  Ser Asp Pro Val Leu  Asn Cys Leu 
    1490                 1495                 1500             


Thr Leu  Glu Leu His Ile Asn  Gly Gln Arg Leu Gln  His Gln Thr 
    1505                 1510                 1515             


Gly Phe  Glu Gln Thr Thr Leu  Glu Thr Ser Leu Gln  Met Gly Pro 
    1520                 1525                 1530             


Leu Glu  Ala Glu Glu Leu Gln  Lys Ala Asn Glu Thr  Glu Asn Asp 
    1535                 1540                 1545             


Ile Lys  Val Leu Gly Gly Pro  Lys Ile Pro Pro Pro  Lys Ala Leu 
    1550                 1555                 1560             


Gln Ala  Leu Glu Asn Ser Asp  Gly Leu Ile Leu Asn  Ala Tyr Gln 
    1565                 1570                 1575             


Lys Asp  Asn Glu Leu Val Lys  Ser Asp Glu Glu Leu  Asn Gln Pro 
    1580                 1585                 1590             


Gly Ser  Thr Asn Ile Gln Val  Gln Pro Gln Thr His  Phe Thr Gln 
    1595                 1600                 1605             


Thr Ile  Leu Lys Ser Thr Ser  Cys Pro Thr Leu Asp  Gln Phe Pro 
    1610                 1615                 1620             


Phe Glu  Lys Val Glu Ser His  Val Arg Phe Ser Pro  Leu Lys Ser 
    1625                 1630                 1635             


Gly Glu  Ala Lys Val Asp Glu  Ile Ile Phe Tyr Ala  Arg Glu Gly 
    1640                 1645                 1650             


Gly Ile  Ser Ser Asp Ser Ser  His Gln Lys Glu Gln  Ala Gly Gly 
    1655                 1660                 1665             


Thr Glu  Lys Lys Glu Thr Ala  Ile Phe Gly Ser Cys  Met Pro Ala 
    1670                 1675                 1680             


Leu Ser  Thr Pro Lys Thr Thr  Arg Asn Leu Lys Gln  Phe Ser Asp 
    1685                 1690                 1695             


Met Lys  Thr Leu Val Asn Pro  Lys Cys Gly Ile Ile  Lys Ala Lys 
    1700                 1705                 1710             


Lys Pro  Ser Ile Ser Tyr Met  Leu Asn Ile Arg Ala  Gly Ala Gly 
    1715                 1720                 1725             


Pro Lys  Arg Arg Lys Glu Leu  Ser Cys Asn Leu Thr  Thr Lys Met 
    1730                 1735                 1740             


Lys Glu  Leu His Gln Gly Lys  Lys Gly Val Asp Glu  Thr Tyr Ala 
    1745                 1750                 1755             


Phe Leu  Thr Met Thr Pro Asp  Ile Asn Lys Tyr Ser  Lys Val Glu 
    1760                 1765                 1770             


Thr Glu  Lys Asp Thr Leu Arg  Glu Lys Arg Leu Ser  Ser Thr Gln 
    1775                 1780                 1785             


Val Lys  Gln Asp Thr Ser Pro  His Glu Asp Ser Ile  Thr Ser Arg 
    1790                 1795                 1800             


Asp Ile  Lys Glu Thr Leu Leu  Gln Asp Glu Glu Gln  Glu Glu Arg 
    1805                 1810                 1815             


Lys Gln  Glu Ala Leu Leu Lys  Val Ile Pro Gln His  Leu Gln His 
    1820                 1825                 1830             


Phe Met  Phe Arg Ser Gly Gln  Gly Lys Asp Leu Asp  Phe His Lys 
    1835                 1840                 1845             


Leu Glu  Asn Gln Gly Ser Arg  Lys Ile Leu Phe Val  Thr Lys Gln 
    1850                 1855                 1860             


Asp Val  Pro Gln Gln Leu Gln  Pro Ala Glu Pro Ile  Gln Arg Glu 
    1865                 1870                 1875             


Glu Thr  Lys Lys Cys Leu Gln  Thr Gln Asn Gly Thr  Ile Cys Thr 
    1880                 1885                 1890             


Val Asn  Ser Lys Leu Leu Pro  Leu Lys Ser Glu Asp  Ser Val Asn 
    1895                 1900                 1905             


Gly Glu  Val Leu Thr Gly Ala  Ile Lys Arg Gly Val  Pro Thr Asp 
    1910                 1915                 1920             


Arg Lys  Cys Met Gly Glu Gln  His Asn Ser Gly Lys  Gly Glu Lys 
    1925                 1930                 1935             


Ala Glu  Phe Asn Lys Asp Leu  Gln Ala Thr Val Leu  Glu Leu Gln 
    1940                 1945                 1950             


Lys Ser  Pro His Gly Gly Glu  Ala Gln Lys Ala Asn  Leu Thr Asp 
    1955                 1960                 1965             


Met Glu  Ser Gly Ser Ser Asn  Ala Met Asn Met Asn  Val Gln His 
    1970                 1975                 1980             


Glu Arg  Glu Asp Lys Asn Ile  Gln Lys Met Leu Thr  Glu Ser Val 
    1985                 1990                 1995             


Pro Cys  Tyr Ser Gln His Leu  Arg Phe Ser Thr His  Gln Met Lys 
    2000                 2005                 2010             


Asp Pro  Asp Pro Cys Lys Ser  Gly Ser Glu Pro Lys  Ser Pro Glu 
    2015                 2020                 2025             


Gly Arg  Ser Trp Asn Leu Ser  His Ile Val Gln Lys  Thr Lys Gln 
    2030                 2035                 2040             


Glu Thr  His Phe Arg Glu Thr  Val Leu Glu Pro Ile  Ser Gly Tyr 
    2045                 2050                 2055             


Met Met  Lys Gln Ser Pro His  Met Gln Glu Gly Ile  Lys Cys Met 
    2060                 2065                 2070             


Glu Gly  Leu Lys Thr Ser Phe  Pro Lys Thr Gly Lys  Ser Lys Ile 
    2075                 2080                 2085             


Gly Ser  Ile Pro Arg Asp Thr  Pro Trp Asp Glu Asn  Pro Arg Arg 
    2090                 2095                 2100             


Lys Trp  Asp Ser Ser Ile Ser  Glu Lys Thr Ala Trp  Asn Gln Lys 
    2105                 2110                 2115             


Asn Leu  Gln Thr Val Leu Lys  Pro Leu Asp Phe Ser  Ser Leu Met 
    2120                 2125                 2130             


Ser Ser  Glu Tyr Glu Ser Arg  Ser Tyr Thr Leu Glu  Phe Ile Gly 
    2135                 2140                 2145             


Lys Lys  Ser Met Ser Pro Lys  Cys Val Thr Leu Lys  Ala Lys Gln 
    2150                 2155                 2160             


Leu Arg  Ile Leu Gln Leu Phe  Asn Ile Ile Arg Tyr  Ser Thr Glu 
    2165                 2170                 2175             


Asn His  Arg Lys Lys Lys Gln  His Arg Phe Lys Tyr  Lys Met Lys 
    2180                 2185                 2190             


Gly Lys  Gln Trp Tyr Thr Ser  Ile Gly Glu Ala Leu  Leu Ser Ala 
    2195                 2200                 2205             


Thr Glu  Tyr Ala Lys Ser Thr  Thr Ser Lys Ser Met  Ile Asp Lys 
    2210                 2215                 2220             


Leu Leu  Tyr Asn Thr Ala Ala  Arg Cys Ile Leu Ser  Asn Arg Thr 
    2225                 2230                 2235             


Arg Arg  Gln Asn Leu Asp Gly  His Ile Thr Glu Glu  Lys Glu Glu 
    2240                 2245                 2250             


Val Gln  Glu Asn Val Ala Ala  Ile Phe Leu Gly Leu  Leu Asp Phe 
    2255                 2260                 2265             


Phe Met  Pro Val Leu Ser Asp  Ser Lys Asn Gln Arg  Asn Thr Ala 
    2270                 2275                 2280             


Gln Leu  Ser Glu Lys Glu Ile  Ile Phe Asn Ala Lys  Cys Leu Thr 
    2285                 2290                 2295             


Met Lys  Glu Lys Lys Ser Ser  Ile Ser Gln Ile His  Lys Ile Asn 
    2300                 2305                 2310             


Arg Glu  Ser Thr Arg Lys His  Arg Lys Lys Cys Lys  Ser Tyr Leu 
    2315                 2320                 2325             


Lys Thr  Val Ser Asn Arg Lys  Cys Gln Glu Asn His  Gly His Ile 
    2330                 2335                 2340             


Thr Glu  Glu Glu Glu Glu Val  Gln Glu Asn Ser Pro  Ala Thr Phe 
    2345                 2350                 2355             


Leu Gly  Pro Leu Asp Phe Phe  Met Pro Val Leu Ser  Asp Ser Lys 
    2360                 2365                 2370             


Asn Gln  Ile Asn Thr Ile Gln  Leu Ser Glu Arg Lys  Ile Ile Leu 
    2375                 2380                 2385             


Asn Pro  Lys Cys Leu Thr Met  Lys Glu Lys Lys Pro  Pro Ile Ser 
    2390                 2395                 2400             


Gln Ile  His Lys Ile Ser Gly  Gln Phe Thr Thr Lys  His Arg Lys 
    2405                 2410                 2415             


Lys Leu  Glu Ser Asn Leu Lys  Thr Lys Leu Lys Ala  Met Trp Gln 
    2420                 2425                 2430             


Gly Glu  Asn Val Ala Asp Thr  Phe Pro Asn Thr Thr  Ser Phe Thr 
    2435                 2440                 2445             


Pro Asp  Ser Ser Asp Ile Lys  Arg Gln Ser Gly Phe  Gln Thr Glu 
    2450                 2455                 2460             


Ile Asp  Met Arg Ile Ser Gly  Leu Ser His Thr Gln  Pro Thr Gln 
    2465                 2470                 2475             


Ile Glu  Ser Leu Ala Glu Gly  Ile Ala Arg Tyr Ser  Asp Pro Ile 
    2480                 2485                 2490             


Asp Lys  Arg Arg Thr Ser Asn  Leu Val Lys Gly Ala  Lys Leu His 
    2495                 2500                 2505             


Asp Arg  Glu Ser Gly Glu Glu  Lys Gln Glu His Leu  Thr Glu Met 
    2510                 2515                 2520             


Asp Pro  Phe Tyr Ala Glu Asn  Phe Met Ala Asn Thr  Tyr Leu Arg 
    2525                 2530                 2535             


Lys Asp  Arg His Leu Gly Lys  Ser Glu Asp Val Leu  Leu Gly Glu 
    2540                 2545                 2550             


Thr Phe  Phe Ser Lys Ser Gln  Ile Tyr Lys Gly Asn  Ser Glu Lys 
    2555                 2560                 2565             


Asn Val  Lys Ile Glu Lys Asn  Lys Asn Gly Lys Glu  Ser Leu Lys 
    2570                 2575                 2580             


Val Gly  Leu Ala Arg Met Glu  Lys Ser Asp Asn Cys  Ala Glu Leu 
    2585                 2590                 2595             


Ser Glu  Ala Thr Asp Asp Ala  Ile Ser Asn Lys Tyr  Asp Lys Gln 
    2600                 2605                 2610             


Asn Ile  Gly His Ser Val Leu  Lys Glu Asn Ala Phe  Cys Asn Leu 
    2615                 2620                 2625             


Ala Ala  Ile Val Pro Asp Ser  Val Gly Arg His Ser  Pro Ala Ser 
    2630                 2635                 2640             


Glu Glu  Met Lys Arg Gln Asn  Gly Arg Leu Lys Met  Ala Asp Arg 
    2645                 2650                 2655             


Ser Ser  Pro Gln Gly Arg Pro  Leu Gln Ala Lys Gln  Ser Ala Val 
    2660                 2665                 2670             


Ser Gln  Ser Pro Asp Thr Ala  Gly Tyr Ala Val Val  Ser Asn Asn 
    2675                 2680                 2685             


Lys Glu  Gln Lys Gln Asn Phe  Lys Ala Gln Lys Thr  Glu Ala Glu 
    2690                 2695                 2700             


Val Asp  Leu Ile Asp Gln Glu  Ala Lys Ile Asn Val  Ala Glu Glu 
    2705                 2710                 2715             


Phe Asn  Pro Glu Ser Val Phe  Phe Ser Lys Ile His  Pro Leu Gln 
    2720                 2725                 2730             


Ile Glu  Asn Lys Lys Glu Phe  Lys Thr Ala Asp Trp  Lys Thr Arg 
    2735                 2740                 2745             


Ala Asp  Pro Lys Thr Phe Ala  Leu Pro Lys Lys Gln  Gln Glu Leu 
    2750                 2755                 2760             


Cys Val  Ser Gly Thr Ile Trp  Ser Tyr Pro Asn Pro  Tyr Thr Ser 
    2765                 2770                 2775             


Ile Ser  Pro Lys Ile Ile Arg  His Lys Asp Lys Ala  Lys Thr Ala 
    2780                 2785                 2790             


Asp Val  Glu Ser Thr Met His  Thr Lys Gln Ile Lys  Leu Lys Ala 
    2795                 2800                 2805             


Lys Arg  Ile Thr Val Ser Gln  Leu Leu Glu Tyr Gly  Thr Ala Ser 
    2810                 2815                 2820             


Asn Lys  Lys Glu Leu Arg Gly  Asn Ile Gln Gln Gln  Lys Ser Phe 
    2825                 2830                 2835             


Gln Leu  Ser Lys Asn Ala Val  His Arg Val Leu Lys  Ala Val Tyr 
    2840                 2845                 2850             


Asp Ser  Gly Tyr Cys Val Ser  Ser Ile Lys Lys Leu  Thr Glu Val 
    2855                 2860                 2865             


Lys Met  Glu Lys Asp Lys Pro  Lys Asp Arg Thr Cys  Ile Leu Pro 
    2870                 2875                 2880             


Gln Pro  Lys Leu Glu Lys Pro  Leu Lys Glu Met Gln  Arg Ser Leu 
    2885                 2890                 2895             


Ser Gly  Cys Thr Asp Met Ser  Ser Ile Leu Arg Lys  Gln Glu Gln 
    2900                 2905                 2910             


Asp Ile  Arg Glu Lys Glu Gln  Lys His Gln Ser Ile  Ser Glu Asp 
    2915                 2920                 2925             


Ile Ser  Gln Tyr Tyr Ile Gly  Pro Leu Arg Ile Ser  Ser Gln Gln 
    2930                 2935                 2940             


Ile Asn  Tyr Ser Ser Phe Asp  Ala Pro Arg Ile Arg  Thr Asp Glu 
    2945                 2950                 2955             


Glu Leu  Glu Phe Leu Ile Ala  Gln Arg Ala Lys Glu  Lys Asp Val 
    2960                 2965                 2970             


Gly Ile  Ala Lys His Ser Val  Ser Ile Pro Trp Glu  Arg Glu Gly 
    2975                 2980                 2985             


Ser Lys  Arg Leu Asp Ile Pro  Leu Asn Ser Lys Gly  Gln Asn Ile 
    2990                 2995                 3000             


Phe Phe  Thr Glu Leu Asp Thr  Ser Gln Gln Lys Thr  Cys Gln Glu 
    3005                 3010                 3015             


Gln Glu  Leu Leu Lys Gln Glu  Asp Ile Ser Met Thr  Asn Leu Gly 
    3020                 3025                 3030             


Ser Met  Ala Cys Pro Ile Met  Glu Pro Leu His Leu  Glu Asn Thr 
    3035                 3040                 3045             


Gly Lys  Val Thr Glu Glu Glu  Asp Val Tyr Ile Asn  Arg Lys Ile 
    3050                 3055                 3060             


Ser Ser  His Val Leu Gly Lys  Glu Gly Leu Lys Glu  Thr Asp Ile 
    3065                 3070                 3075             


Phe Val  Gly Ser Lys Gly Gln  Lys Phe Leu Cys Thr  Asn Ser Glu 
    3080                 3085                 3090             


Val Gln  His Lys Val Pro Ala  Glu Gln Lys Glu Gln  Val Asn Pro 
    3095                 3100                 3105             


Asp His  Val Pro Glu Ser Ile  Leu Asp Ser Glu Ser  Phe Leu Ser 
    3110                 3115                 3120             


Lys Asp  Pro Leu His Leu Lys  Gln Ala Val Asn Thr  Ala Arg Lys 
    3125                 3130                 3135             


Glu Asn  Val Thr Ile Ser Glu  Ser Phe Asn Glu Asn  Leu Trp Gly 
    3140                 3145                 3150             


Lys Glu  Gln Ser Lys Leu Asp  Ile Thr Leu Lys Ser  Asn Arg Gln 
    3155                 3160                 3165             


Lys Met  Asp Phe Ser Lys Lys  Leu Arg Met Lys His  Leu Ser Asn 
    3170                 3175                 3180             


Tyr Tyr  Gln Asn Lys Glu Asn  Ile Leu Glu Ser Val  Leu Pro Cys 
    3185                 3190                 3195             


Ile Leu  His Gln Leu Tyr Ile  Glu Asn Pro Lys Lys  Glu Gly Ser 
    3200                 3205                 3210             


Ala Glu  Glu Ile Met Ser Ser  Lys Val Leu Ser Pro  Met Val Glu 
    3215                 3220                 3225             


Lys Ala  Ser His Glu Val Gly  Ile Pro Val Asp Gln  Pro Pro Cys 
    3230                 3235                 3240             


Ser Glu  Gly Ile His Leu Asn  Ile Lys Gly Arg Lys  Glu His Pro 
    3245                 3250                 3255             


Gln Glu  Ser Thr His Glu Ala  Phe Pro Ala Ser Val  Ser His Ser 
    3260                 3265                 3270             


Leu Met  Asp Val Leu Gln Ile  Lys Ser Pro Lys Val  Lys Lys Ala 
    3275                 3280                 3285             


Leu Lys  Ala Ile Asn Ser Leu  Gly Tyr Leu Thr Ser  Asn Thr Lys 
    3290                 3295                 3300             


Gly Ile  Gly Leu Leu Phe Pro  Arg Gln Ala Glu Lys  Glu Glu Lys 
    3305                 3310                 3315             


Tyr Thr  Tyr Lys Ala Leu Pro  Lys Pro Ala Ser His  Ser Lys Thr 
    3320                 3325                 3330             


Asp Leu  Phe Gln Phe Asn Ala  Ser Met Gln Gln Glu  Lys Leu Asp 
    3335                 3340                 3345             


Ala Met  Asp Ile Pro His Tyr  Asp Tyr Leu Thr Ser  Gln Thr Arg 
    3350                 3355                 3360             


Glu Ala  Val Lys Gln Met Asp  Val Ile Val Gly Tyr  Thr Gln Asn 
    3365                 3370                 3375             


Ser Lys  Lys Arg Gln Asp Leu  Leu Lys Thr Gly Gln  Lys Trp Gln 
    3380                 3385                 3390             


Tyr Leu  Pro Ile Ser Tyr Glu  Asn Phe Trp Glu His  Ile Ser Cys 
    3395                 3400                 3405             


Pro Gln  Lys Tyr Pro Cys Leu  Leu Gln His Leu Met  Pro Gln Glu 
    3410                 3415                 3420             


Lys Glu  Ala Leu Ser Glu Gly  Gly Asn Leu Ser Ser  Arg Thr Pro 
    3425                 3430                 3435             


Gly Leu  Asp Leu Phe Ser Ala  Asp Gln Leu Ser Thr  Ile Thr Lys 
    3440                 3445                 3450             


Asn Arg  Leu Glu Trp Ile Val  Pro Leu Ile Ser Pro  Arg Gln Met 
    3455                 3460                 3465             


Lys Lys  Gln Asp Ser Met Leu  Pro Leu Gly Ser Tyr  His Lys Thr 
    3470                 3475                 3480             


Ile Lys  Tyr Ala Ser Leu Leu  Phe Pro Lys Gly Met  Lys Ser Ser 
    3485                 3490                 3495             


Asp Gly  Val Gln Val Phe Asp  Leu Ile Ser Asn Asn  Ser Ser Pro 
    3500                 3505                 3510             


Lys Leu  Arg Leu Gly Lys Lys  Ile Glu Thr Gln Lys  Ala Asn Glu 
    3515                 3520                 3525             


Lys Val  Gln Lys Glu Val Cys  Leu Pro Ile Thr Leu  His Ser Leu 
    3530                 3535                 3540             


Ser Ala  Ser Met Pro Ile Leu  Gln Glu Ser Lys Gly  Gln Lys Asp 
    3545                 3550                 3555             


Ser Val  Glu Gln Val Ile Arg  Lys Gly Val Ile Cys  His Lys Arg 
    3560                 3565                 3570             


Arg Thr  Ser Lys Trp Lys Lys  Ser Val Phe Ser His  Ile Leu Asn 
    3575                 3580                 3585             


Thr Ser  Asp Cys Gly Ala Ser  Ser Asn Arg Leu Glu  Met Gln Trp 
    3590                 3595                 3600             


Asn Met  Thr Asp Lys Met Val  Asn Val Lys His Arg  Met Ser Glu 
    3605                 3610                 3615             


Ile Asp  Leu Val Ala Ala Lys  Ile Cys Glu Ser Ile  Leu Ser Leu 
    3620                 3625                 3630             


Pro His  Phe Lys Leu Asn Lys  Glu Thr Ile Asp Gly  Val Ile Ser 
    3635                 3640                 3645             


Ser Asn  Val Lys Ser Thr Lys  Gln His Ile Ser Gln  Gly Lys Asn 
    3650                 3655                 3660             


Asp Arg  Val Lys Ala Met Asp  Met Lys Arg Ile Lys  Ser Pro Asn 
    3665                 3670                 3675             


Ile Ile  Leu Lys Pro Arg Lys  Ser Ser Leu Ser His  Ile Leu Ser 
    3680                 3685                 3690             


Ile Lys  Glu Phe Pro Leu Leu  Leu Asp Ile Ile Lys  Gln Glu Gly 
    3695                 3700                 3705             


Lys Met  Gln Glu Gly Lys Gly  Lys Ser Ser Met Lys  Leu Thr Asn 
    3710                 3715                 3720             


Leu Cys  Thr Ser Leu Pro Ser  Leu Ser His Ser Asn  Ser Asn Ser 
    3725                 3730                 3735             


Arg Thr  Lys Ala Gly Lys Asp  Lys Ser Gly Thr Leu  Lys Gly Cys 
    3740                 3745                 3750             


Leu Pro  Pro Leu Lys Leu Gln  Ala Ser Ser Asn Ala  Arg Arg Val 
    3755                 3760                 3765             


Ser Ser  Ala Glu Ser Ile Asn  Arg Asp Ser Leu Ser  Asn Val Ile 
    3770                 3775                 3780             


Glu Ser  Lys Cys Phe Pro Gln  Lys Lys Lys Glu Asp  Arg Glu Asn 
    3785                 3790                 3795             


Ile Val  Asp Val Lys Asp Val  Met Gly Leu Lys Cys  Ile Thr Leu 
    3800                 3805                 3810             


Lys Gly  Lys Lys Ser Leu Phe  Arg His Leu Leu His  Gly Lys Glu 
    3815                 3820                 3825             


Pro Gln  Arg Ser Asn Lys Lys  Leu Glu Lys Met Thr  Gln Glu Asp 
    3830                 3835                 3840             


Glu Ser  Asn Leu Asn Val Val  Gln Asn Lys Leu Cys  Ala Ser Ile 
    3845                 3850                 3855             


Leu Ser  Pro Pro His Leu Glu  Trp Asn Pro Arg Ile  Lys Glu Val 
    3860                 3865                 3870             


Tyr Met  Arg Gly Ile Thr Arg  Phe Cys Leu Ser Ser  Ser Thr Gln 
    3875                 3880                 3885             


Gln Glu  Leu Ser Asp Thr Met  Glu Lys Cys Glu Gln  Pro Ile Asp 
    3890                 3895                 3900             


Asp Ser  Leu Ser Ser Ile Glu  Lys Ala Lys His Met  Pro Gln Lys 
    3905                 3910                 3915             


Asp Lys  Asp Arg Val Glu Lys  Ala Leu Glu Lys Ile  Met His Ser 
    3920                 3925                 3930             


Lys Arg  Ile Ala Leu Glu Val  Lys Gln Pro Ser Ile  Phe Gln Glu 
    3935                 3940                 3945             


Leu Glu  Leu Asn Ile Lys Glu  Lys Gly Gly Lys Ile  Gln Glu Asp 
    3950                 3955                 3960             


Lys Glu  Val Glu Ile Trp Ser  Lys Pro Phe Ala Ser  Ile Ser Phe 
    3965                 3970                 3975             


Leu Pro  Tyr Ser Lys Val Gly  Thr Ile Glu Gly Glu  Glu Ala Met 
    3980                 3985                 3990             


Arg Ile  Lys Met Arg Ser Ser  Phe Ser Gln Pro Asn  Leu Gln Glu 
    3995                 4000                 4005             


Ser Ser  Asp Thr Glu Lys Thr  Ala Tyr Glu Lys Cys  Ile Ser Asp 
    4010                 4015                 4020             


Asn Ile  Ser Asn Ser Val Lys  Lys Ala Leu Glu Ser  Ile Leu Gln 
    4025                 4030                 4035             


Lys Glu  Gln Arg Gln Lys Met  Glu Lys Ile Arg Ala  Leu Lys Lys 
    4040                 4045                 4050             


Met Lys  Ser Ser Ile Ser Gln  Gly Ile Gln Leu Asp  Ile Lys Glu 
    4055                 4060                 4065             


Gln Glu  Lys Arg Ile Glu His  Ile Lys Gly Glu Pro  Ser Val Leu 
    4070                 4075                 4080             


Leu Thr  Asn Ala Cys Ala Ser  Ile Pro Ser Pro Ser  His Leu Gln 
    4085                 4090                 4095             


Leu Asp  Thr Arg Arg Glu Lys  Ala Glu Tyr Val Thr  Glu Ile Thr 
    4100                 4105                 4110             


Arg Tyr  Tyr Leu Pro Glu Leu  Ser His Gln Lys Ser  Ser Glu Ala 
    4115                 4120                 4125             


Gly Glu  Lys Ala Asp Gly Val  Ala Ser Lys Gly Asp  Ile Thr Ile 
    4130                 4135                 4140             


Lys Val  Gln Lys Ala Lys Asp  Tyr Met Gln Gln Lys  Glu Asp Asp 
    4145                 4150                 4155             


Glu Val  Lys Ile Ser Ala Lys  Lys Asp Ile Met His  Pro Glu Asp 
    4160                 4165                 4170             


Lys Gly  Leu Lys Ala Lys Lys  Ala Leu Ser Gln Asp  Leu Pro Leu 
    4175                 4180                 4185             


Asn Thr  Lys Glu Pro Gly Lys  Met Asp Gln Glu Ala  Gln Glu Gln 
    4190                 4195                 4200             


Gly Lys  Glu Asp Arg Glu Gly  Glu Glu Gln Gly Lys  Glu Asp Arg 
    4205                 4210                 4215             


Arg Gly  Ala Gly Gln Glu Lys  Val Asp Arg Glu Asp  Lys Glu Gln 
    4220                 4225                 4230             


Gly Lys  Met Asp His Glu Val  Glu Glu Gln Gln Lys  Ala Asp Gly 
    4235                 4240                 4245             


Val Gly  Ile Glu Gln Gly Lys  Met Asp Gly Asp Lys  Asn Glu Gln 
    4250                 4255                 4260             


Glu Arg  Val Leu Phe Leu Tyr  Leu Pro Ser Asn Ser  Ser Leu Thr 
    4265                 4270                 4275             


His Tyr  Ile Leu Asp Thr Arg  Ile Glu Gly Glu Glu  Asp Gln Gln 
    4280                 4285                 4290             


Gly Ile  Ile Arg Pro Gly Ile  Leu Gln Pro Arg His  Gln Lys Ser 
    4295                 4300                 4305             


Ser Glu  Thr Gly Lys Lys Ala  Asn Gly Val Pro Ser  Glu Gly Asp 
    4310                 4315                 4320             


Ser Ala  Ser Glu Val Gln Lys  Ala Lys Asp Tyr Met  Gln Gln Lys 
    4325                 4330                 4335             


Glu Glu  Asp Glu Val Lys Ile  Ser Ala Glu Lys Asp  Leu Met His 
    4340                 4345                 4350             


Pro Glu  Asp Lys Asp Leu Lys  Gly Lys Lys Ala Leu  Ser Gln Asn 
    4355                 4360                 4365             


Leu Pro  Leu Asn Pro Lys Glu  Pro Gly Lys Arg Asp  Gly Glu Gly 
    4370                 4375                 4380             


Gln Glu  Gln Gly Lys Glu Asp  Gly Glu Gly Glu Glu  Gln Gly Asn 
    4385                 4390                 4395             


Arg Asp  Gly Glu Thr Glu Glu  Gln Gln Gln Ala Asp  Gly Val Gly 
    4400                 4405                 4410             


Thr Glu  Gln Glu Lys Arg Asp  Gly His Lys Ser Lys  Gln Glu Thr 
    4415                 4420                 4425             


Val Leu  Phe Leu His Leu Pro  Ser Glu Ser Ser Leu  Thr Cys Tyr 
    4430                 4435                 4440             


Glu Leu  Asn Thr Arg Lys Glu  Gly Glu Glu Asp Leu  Gln Gly Ile 
    4445                 4450                 4455             


Ile Lys  Ser Ala Thr Leu Gln  Leu Arg Gln Gln Lys  Ser Phe Asp 
    4460                 4465                 4470             


Ala Gly  Lys Ile Ala His Thr  Lys Ser Phe Gly Val  Asp Ser Ser 
    4475                 4480                 4485             


Asn Asp  Val Lys Thr Val Gln  Glu Tyr Lys Pro Gln  Lys Glu Val 
    4490                 4495                 4500             


Asp Arg  Gly Lys Thr Val Ser  Val Asp Tyr Ile Met  Gln Pro Glu 
    4505                 4510                 4515             


Gly Thr  Ile Phe Glu Ala Glu  Gln Leu Ser Leu Pro  His Thr Leu 
    4520                 4525                 4530             


Asn Ile  Pro Gly Ser Ser Gly  Ser Lys Thr Arg Glu  Val Leu Thr 
    4535                 4540                 4545             


Asn Ile  Lys Glu Lys Leu Arg  His Val Gln Glu Arg  Lys Ser Glu 
    4550                 4555                 4560             


Leu Asp  Val Phe Leu Thr Ile  Pro Ser Leu Ser His  Cys Lys Leu 
    4565                 4570                 4575             


Asp Lys  Arg Thr Ala Gly Lys  Lys Glu Glu Gln Gly  Val Thr Arg 
    4580                 4585                 4590             


Ser Phe  Leu Pro Pro Ser Trp  His Met Glu Ser Ser  Asp Thr Gly 
    4595                 4600                 4605             


Lys Leu  Lys Tyr Thr Leu Ser  Tyr Leu Asn Asp Ile  Thr Gly Asp 
    4610                 4615                 4620             


Ser Asn  Arg Thr Lys Tyr Met  Ala Gln Ile Gln Lys  Asp Lys Ala 
    4625                 4630                 4635             


Asn Ile  Ser Glu Lys Ser Val  Met His Pro Glu Tyr  Ile Ala Val 
    4640                 4645                 4650             


Lys Ala  Glu Lys Ser Pro Leu  Ser His Ile Leu Lys  Thr Lys Glu 
    4655                 4660                 4665             


Leu Gln  Val Asn Ile Ser Gln  Gln Gly Glu Lys Ala  Gln Glu Gly 
    4670                 4675                 4680             


Glu Val  Glu Ile Val Val Leu  Leu Ser Lys Thr Cys  Pro Phe Val 
    4685                 4690                 4695             


Thr Ser  Ser Ala Phe Leu Glu  Leu Asp Ser Ile Lys  Glu Glu Glu 
    4700                 4705                 4710             


Gly Glu  Pro Arg Ile Thr Arg  Ser Phe Met Pro His  Leu Glu Ile 
    4715                 4720                 4725             


Gln Glu  Ser Leu Pro Ser Arg  Gln Thr Ala Pro Thr  Lys Pro Thr 
    4730                 4735                 4740             


Glu Ser  Leu Val Lys Lys Glu  Lys Gln Leu Leu Pro  Gln Lys Glu 
    4745                 4750                 4755             


Asp Arg  Val Gln Thr Val Ser  Met His Gly Leu Met  His Pro Asn 
    4760                 4765                 4770             


Gly Ala  Val Phe Lys Ala Lys  Thr Ser Ala Pro Pro  Gln Val Phe 
    4775                 4780                 4785             


Ser Ile  Thr Glu His Ser Pro  Leu Ser Lys Arg Lys  Glu Pro Gln 
    4790                 4795                 4800             


Trp Gly  Met Lys Glu Arg Ala  Gly Gln Lys Gln Asp  Arg Thr Gly 
    4805                 4810                 4815             


Arg Pro  His Val Ile Leu Thr  Lys Thr His Pro Phe  Met Pro Ser 
    4820                 4825                 4830             


Leu Ser  His His Arg Phe Ser  Pro Ser Gln Pro Lys  Leu Pro Ile 
    4835                 4840                 4845             


Ser Ser  Gly Ala Gly Lys Ser  Arg Leu Ala Asn Ser  Asn Glu Gly 
    4850                 4855                 4860             


Ile Ser  Ser His Lys Val Ile  Leu Lys Ala Asn Gln  Gln Met Pro 
    4865                 4870                 4875             


Tyr Lys  Glu Ala Lys Asp Arg  Val Lys Ile Glu Gly  Arg Glu Gly 
    4880                 4885                 4890             


Arg Ile  Leu Pro Lys Arg Ile  His Leu Arg Ala Glu  Ala Leu Pro 
    4895                 4900                 4905             


Leu Ala  Leu Leu Cys Asn Gly  Lys Asn Tyr Ser Leu  His Ile Glu 
    4910                 4915                 4920             


Glu Gln  Gly Glu Gly Val Gln  Glu Ser Lys Lys Glu  Pro Gly Val 
    4925                 4930                 4935             


Val Pro  Arg Lys Ser Ala Ser  Phe Pro Pro Pro Pro  Phe Tyr Leu 
    4940                 4945                 4950             


Asn Cys  Asp Thr Arg Arg Asn  Glu Lys Glu Gly Thr  Leu Gly Lys 
    4955                 4960                 4965             


Thr Gln  Phe Ser Phe Pro Pro  Leu Lys Ile Gln Asp  Ser Ser Asp 
    4970                 4975                 4980             


Ser Gly  Lys Lys Ala Tyr Thr  Glu Ser Leu His Gly  Tyr Thr Leu 
    4985                 4990                 4995             


Ser Asn  Ser Lys Gly Pro Val  Gln Pro Thr Ala Gln  Gly Glu Glu 
    5000                 5005                 5010             


Lys Gly  Gly Leu Arg Ile Asp  Met Glu Asp Lys Met  Leu Pro Lys 
    5015                 5020                 5025             


Cys Thr  Asp Leu Lys Ala Lys  Gln Leu Leu Leu Ser  Asp Ile Leu 
    5030                 5035                 5040             


Asn Thr  Lys Lys Leu Gln Trp  Lys Ser Lys Glu Gln  Lys Arg Lys 
    5045                 5050                 5055             


Ile Gln  Glu Asp Lys Asn Lys  Gln Val Lys Gly Leu  Pro Ser Ile 
    5060                 5065                 5070             


Asn Thr  Ser Leu Leu Thr Pro  Pro Tyr Leu Lys Phe  Asp Thr Thr 
    5075                 5080                 5085             


Glu Gly  Gln Glu Asn Val Ile  Arg Ile Ala Lys Val  Ser Leu Pro 
    5090                 5095                 5100             


Gln Ser  Arg Ser Lys Glu Ser  Ser Asp Ala Gly Arg  Ile Ala Cys 
    5105                 5110                 5115             


Pro Glu  Ala Thr His Gly Glu  Leu Ser Ser Asp Val  Lys Gln Leu 
    5120                 5125                 5130             


Lys Ala  His Leu Leu Gln Lys  Glu Glu Lys Asp Arg  Glu Lys Val 
    5135                 5140                 5145             


Ala Asp  Met Thr Ser Val Leu  Asp Pro Asn Lys Met  Tyr Leu Lys 
    5150                 5155                 5160             


Ala Lys  Lys Ser Pro Val Leu  His Thr His Ser Phe  Ser Asp Leu 
    5165                 5170                 5175             


Gln Trp  Lys Thr Arg Glu Gln  Glu Glu Glu Lys Val  Gln Lys Val 
    5180                 5185                 5190             


Lys Ser  Gly Pro Gly Val Met  Leu Ser Lys Ser Pro  Ser Arg Ser 
    5195                 5200                 5205             


Ser Pro  Leu His Leu Asn Val  Asn Thr Gly Phe Gln  Glu Glu Ser 
    5210                 5215                 5220             


Ile Pro  Ile Leu Thr Arg Pro  Ser Phe Pro Leu Val  Lys Leu Gln 
    5225                 5230                 5235             


Val Ser  Pro Asp Thr Glu Gly  Gly Thr Cys Ile Arg  Pro Ile Ala 
    5240                 5245                 5250             


Gly Asp  Ile Leu Ile Tyr Leu  Gln Lys Gly Lys His  Val Ser Gln 
    5255                 5260                 5265             


Asn Lys  Glu Glu Asp Asp Val  Gln Ile Val Ser Ile  Leu Ile Phe 
    5270                 5275                 5280             


Pro Lys  His Gln Glu Glu Lys  Val Gln Glu Cys Glu  Gly Glu Pro 
    5285                 5290                 5295             


Gly Val  Val Leu Thr Lys Ser  Thr Ser Leu Pro Ser  Leu Ser Gln 
    5300                 5305                 5310             


Leu Glu  Leu Asp Lys Glu Thr  His Leu Gly Asn Glu  Met Leu Arg 
    5315                 5320                 5325             


Leu Lys  Arg Pro Ile Leu Arg  Arg Ile Ser His Ile  Gly Glu Thr 
    5330                 5335                 5340             


Val His  Arg Glu Ser Val Val  Gly Asp Ile Pro Lys  Asp Val Lys 
    5345                 5350                 5355             


Asn Glu  Lys Gln His Ile Pro  Gln Lys Glu Glu Arg  Asn Gln Lys 
    5360                 5365                 5370             


Lys Ile  Ile Asp Met Arg Gly  Thr Asp Ile Thr Leu  Lys Ser Lys 
    5375                 5380                 5385             


Lys Ser  Pro Arg Ser Cys Met  Leu His Arg Thr Glu  Leu His Val 
    5390                 5395                 5400             


Asn Ile  Gly Gly Gln Gly Arg  Lys Glu His Glu Gly  Gln Asp Lys 
    5405                 5410                 5415             


Pro Pro  Gly Met Ile Gln Arg  Lys Met Cys Ile Leu  Phe Ser Lys 
    5420                 5425                 5430             


Pro Leu  Pro Ser Asn Leu Lys  Leu Glu Arg Ala Thr  His Ala Asp 
    5435                 5440                 5445             


Glu Glu  Arg Leu Gly Gly Lys  Thr Ser Phe Val Leu  Pro Leu Met 
    5450                 5455                 5460             


Pro Ser  Ala Leu Pro Asp Thr  Glu Lys Thr Ala Asp  Ala Glu Ala 
    5465                 5470                 5475             


Arg Ser  Gly Asp Val Arg Lys  Gly Lys Pro His Arg  Ser Gln Lys 
    5480                 5485                 5490             


Glu Asn  Arg His Glu Val Lys  Thr Ile Asp Met Arg  Phe Arg Ile 
    5495                 5500                 5505             


His Cys  Gln Glu Ala Arg Ile  Ser Pro Met Ser His  Ile Leu Asn 
    5510                 5515                 5520             


Ala Lys  Glu Leu Val Leu Asn  Ile Asn Lys Leu Glu  Lys Lys Val 
    5525                 5530                 5535             


His Lys  Asp Lys Asp Glu Ala  Cys Val Val Leu Ser  Arg Thr Phe 
    5540                 5545                 5550             


Leu Ser  Ile Pro Ser Ala Pro  Pro Leu Tyr Leu Asp  Ser Gly Asn 
    5555                 5560                 5565             


Lys Thr  Asp Lys Asp Thr Pro  Gly Ile Thr Gly Ser  Ser Cys Pro 
    5570                 5575                 5580             


Gln Arg  Thr Leu His Val Pro  Ser Asn Thr Gln Lys  Ile Thr Asn 
    5585                 5590                 5595             


Arg Asp  Ser Val Glu Gly Val  Asp Lys Asn Val Val  Lys Gln Ala 
    5600                 5605                 5610             


Glu Gln  Tyr Val Pro Arg Pro  Glu Ala Glu Gln Gln  Leu Thr Ser 
    5615                 5620                 5625             


Asn Phe  Met Ile Ser Val Gln  Gln Arg Asn Gln Pro  Ser Arg Val 
    5630                 5635                 5640             


Arg Ser  Glu Glu Asp Leu Asn  Gln Leu Val Leu Asn  Ser Arg Asp 
    5645                 5650                 5655             


Glu Asp  Ile Tyr Phe Thr Gly  Phe Gly Thr Ile Arg  Ser Gly Lys 
    5660                 5665                 5670             


Arg Pro  Glu Trp Leu Phe Thr  Gly Lys Lys Ala Gln  Pro Val Lys 
    5675                 5680                 5685             


Tyr Lys  Thr Glu Thr Leu Thr  Ala Phe Leu Ser Tyr  Pro Thr Met 
    5690                 5695                 5700             


Asp Ala  Thr Lys Met Gly Gly  Leu Glu Glu Asp Thr  Glu Ile Met 
    5705                 5710                 5715             


Asp Asn  Leu Asn His Lys Ile  Ser Pro Lys Ala Ser  Val Ser Leu 
    5720                 5725                 5730             


Ile Arg  Lys Ile Ser Lys Glu  Leu Tyr Val Thr Leu  Gly Thr Pro 
    5735                 5740                 5745             


Ala Asn  Ser Lys Gly Phe Ser  Val Ser Glu Arg Tyr  Ala His Gln 
    5750                 5755                 5760             


Gln Glu  Thr Ser Ser Lys Val  Ser Pro Glu Leu Ala  Gly Ser Cys 
    5765                 5770                 5775             


Lys Phe  Asp Lys Pro Lys Glu  Asp Gly Gln Ser Asn  Asp Arg Ile 
    5780                 5785                 5790             


Ser Lys  Met Phe Ser Pro Lys  Val Leu Ala Pro Gln  Thr Lys Gly 
    5795                 5800                 5805             


Ser Leu  Lys Lys Ile Ser Ile  Val Thr Asn Trp Asn  Ala Pro Gln 
    5810                 5815                 5820             


Asn Ile  Glu Glu Gln Asp Ile  Val Met Lys Lys Gln  Val Ile Arg 
    5825                 5830                 5835             


Arg Cys  Glu His Gly His Lys  Thr Arg Thr Asn Thr  Ile Leu Ser 
    5840                 5845                 5850             


Lys Phe  Pro Leu Gln Ser Gly  Lys Gln Lys Thr Pro  Ser Glu Thr 
    5855                 5860                 5865             


Asp Val  Asp Lys Lys Thr Thr  Ala His Leu Ser Leu  Gln Met Leu 
    5870                 5875                 5880             


Pro Gly  Ile His Met Asp Met  Thr Glu Ile Asp Pro  Ala Lys Gly 
    5885                 5890                 5895             


Gly Arg  Lys Gln Ala Leu Leu  Ile Ser Glu Gln Glu  Glu Gly Val 
    5900                 5905                 5910             


Leu Glu  Phe Leu Pro Lys Ser  Leu Phe Pro Pro Trp  Thr Phe Gln 
    5915                 5920                 5925             


Phe Gln  Ser Gly Asp Leu Glu  Glu Lys His Gln Thr  Asp Ala Asn 
    5930                 5935                 5940             


Thr Asn  Ile Asn Leu Glu Gln  Lys Lys Leu Glu Met  Asp Asn Asp 
    5945                 5950                 5955             


Ser Thr  Val Asn Gln Lys Glu  Gly Lys Leu Lys Ile  Gly Thr Asn 
    5960                 5965                 5970             


Arg Ala  Leu His Leu Gln Glu  Glu Lys Thr Glu Met  His Lys Ala 
    5975                 5980                 5985             


Arg Thr  Ala Asn Leu Glu Lys  Glu Arg Gly Arg Met  Asp Thr Ser 
    5990                 5995                 6000             


Ser Ser  Ala His Pro His Leu  Leu Ser Leu Lys Ala  Glu Glu Ser 
    6005                 6010                 6015             


Gln Met  Lys Thr Gln Val Ile  Thr His Arg Glu Asn  Ser Arg Leu 
    6020                 6025                 6030             


Ile Met  Gln Lys Gln Lys Lys  Glu Leu Glu Ala Ser  Asn Ala Lys 
    6035                 6040                 6045             


Gln Ser  Ile Gln Leu Gln Lys  Leu Phe Gln Arg Asn  Val Leu Asp 
    6050                 6055                 6060             


Ser Phe  Tyr Ser Tyr Val Pro  Leu Ser Pro Lys Arg  Lys Asp Gln 
    6065                 6070                 6075             


Lys Gly  Arg Leu Thr Ile Arg  Asp Leu Lys Arg Glu  Leu Ser Thr 
    6080                 6085                 6090             


Lys Tyr  Leu Thr Met Lys Ile  Gln Asn His Pro Ile  Pro Gln Met 
    6095                 6100                 6105             


Leu Asn  Ile Thr Gly Arg Gly  Thr Pro Ser Asn Arg  Lys Lys Leu 
    6110                 6115                 6120             


Glu Tyr  Asp Val Lys Leu Lys  Asn Ile Ala Ser Trp  Ser Lys Asp 
    6125                 6130                 6135             


Val Ser  Gly Ile Phe Ile Arg  Ser Leu Ser Ile Ser  Ile Met Arg 
    6140                 6145                 6150             


Ser Pro  His Thr Asp Pro Lys  Thr Asn Leu Glu Arg  Glu Lys Arg 
    6155                 6160                 6165             


Ile Cys  Leu Pro Lys Phe Gln  Glu Lys Ser Pro Asn  Thr Ser Glu 
    6170                 6175                 6180             


Met Ser  Lys Arg Asp Thr Leu  Thr Ile Val Lys Gly  Glu Gln Asn 
    6185                 6190                 6195             


Phe Thr  Asn Thr Val Pro Gln  Asp Pro Gln Pro Phe  Ala Val Asp 
    6200                 6205                 6210             


Lys Gln  Gln Met Gln Lys Leu  Pro Asn Val Lys Ser  Glu Ala Asn 
    6215                 6220                 6225             


Leu Arg  Ser Glu Met Asn Lys  Lys Tyr Leu Lys Ala  Gln Thr Lys 
    6230                 6235                 6240             


Glu Arg  Ile Val Pro Glu His  Asp Val Ser Arg Ile  Ile Lys Lys 
    6245                 6250                 6255             


Pro Asp  Leu Arg Ile Ile Glu  Gln Glu Glu Lys Ile  Leu Lys Arg 
    6260                 6265                 6270             


Ile Leu  Thr Pro Thr Glu Cys  Pro Ser Met Leu Glu  Asp Pro Lys 
    6275                 6280                 6285             


Leu Pro  Lys Gln Arg Asp Gln  Ser Glu Pro Val Trp  Asp Met Thr 
    6290                 6295                 6300             


Thr Gln  Lys Val Gln Gln Gln  Lys Ala Phe Pro Gly  Thr Val Pro 
    6305                 6310                 6315             


Ile Pro  Pro Gln Val Lys Ser  Ser Glu Val Lys Ile  Val Ala Asp 
    6320                 6325                 6330             


Ser Thr  Asn Ala Glu His Leu  Leu Pro Ile Cys Glu  Ala Thr Lys 
    6335                 6340                 6345             


Ala Ile  Ser Glu Ser Gln Val  Lys Asn Met Ile Gln  Asp Lys Val 
    6350                 6355                 6360             


Ser Ser  Asp Lys Leu Asp Asn  Ile Gln Ala Tyr Lys  Pro Asp Asp 
    6365                 6370                 6375             


Leu Lys  Ser Pro Pro Phe Pro  Glu Gly Pro Asp Thr  Ile Ser Thr 
    6380                 6385                 6390             


Ala Ile  Tyr Pro Lys Thr Gln  His Lys Ser Leu Leu  Glu Gln Phe 
    6395                 6400                 6405             


Thr Pro  Lys Glu Lys Asn Lys  Leu Thr Ser His Leu  Glu Ser Lys 
    6410                 6415                 6420             


Ala Leu  Glu Ile Gln Leu Asn  Leu Ile Pro Glu Met  Ala Arg Lys 
    6425                 6430                 6435             


Ser Leu  Gln Met Phe Asn Phe  Tyr Pro Lys Gly Thr  Ile Ser Lys 
    6440                 6445                 6450             


Asp Asn  Ser Trp Arg Phe Tyr  Ser Arg His Lys Thr  Met Asn Phe 
    6455                 6460                 6465             


Met Ser  Leu Glu Gly Thr Asp  Thr Ile Glu Pro Asn  Ser Lys His 
    6470                 6475                 6480             


Lys His  Gln Lys Asp Ser Pro  Leu Ala Ser Asn Met  Lys Thr Leu 
    6485                 6490                 6495             


Ile Val  Asp Val Ser Ser Asp  Ser Glu Glu Thr Ile  Thr Lys Leu 
    6500                 6505                 6510             


Gln Ser  Ile Asn Lys Leu Glu  Asn Gly Thr Ser Ala  Val Thr Ser 
    6515                 6520                 6525             


Ala Ser  Glu Met Leu Leu Pro  His Thr Leu Gln Asn  His Ser Val 
    6530                 6535                 6540             


Lys Glu  Lys Gly Lys Leu Leu  Met His Phe Ser Val  Lys Thr Leu 
    6545                 6550                 6555             


Glu Ile  Gln Met Lys Ala Phe  Pro Arg Ile Val Arg  Glu Ser Tyr 
    6560                 6565                 6570             


Ala Met  Thr Ser Ala His Glu  Arg Lys Lys Pro Leu  Ser Asn Cys 
    6575                 6580                 6585             


Ile His  Pro Gly Phe Thr Gly  Pro Lys Arg Gln Asn  Arg Ile Leu 
    6590                 6595                 6600             


Leu Leu  Ser Glu Glu Lys Ser  Leu His Gln Ile Asp  Leu Asp Leu 
    6605                 6610                 6615             


Gln Tyr  Lys Tyr Leu Arg Phe  Leu Leu Gly Leu Pro  Val Gly Ser 
    6620                 6625                 6630             


Thr Phe  Pro Lys Pro Asn Val  Leu Pro Lys His Ser  Lys Leu Asn 
    6635                 6640                 6645             


Thr Ile  Ala Val Cys Lys Asn  Val Asn Ala Gly Gly  Gln Ser Gly 
    6650                 6655                 6660             


Ser Leu  Ser Ile Asp Thr Glu  Leu Leu Glu Gln His  Ile Ser Phe 
    6665                 6670                 6675             


Lys Lys  Gln Ser Pro His Glu  Asn Ser Ser Leu Ile  Arg Lys Phe 
    6680                 6685                 6690             


Pro Gln  Pro Thr Leu Val Cys  Ala Ser Asp Arg Asp  Leu His Ser 
    6695                 6700                 6705             


Pro Arg  Lys Lys Asp Thr Gln  Val Leu Ser Glu Ser  Glu Phe His 
    6710                 6715                 6720             


Val Thr  Pro Glu Lys Asn Lys  Gln Tyr His Val Trp  Phe Gln Glu 
    6725                 6730                 6735             


Arg Asn  Thr Cys Glu Ser Val  Asp Leu Arg Thr Gln  Arg Asn Ala 
    6740                 6745                 6750             


Thr Gly  Ser Ala Val Ser Cys  Glu Thr Gln Ile Ser  Glu Asp Phe 
    6755                 6760                 6765             


Val Asp  Ile Gln Thr Asp Ile  Glu Ser Pro Ala Asp  Leu Asp Glu 
    6770                 6775                 6780             


Cys Ser  Cys Leu Glu Val Ser  Glu Ser Glu Glu Cys  Val Phe Leu 
    6785                 6790                 6795             


Glu Ala  Asn Ser Tyr Leu Ser  Gln Glu Ser Glu Asn  Ile Leu Phe 
    6800                 6805                 6810             


Glu Leu  Gln Thr Gly Ile Pro  Leu Glu Asn Val Tyr  Lys Ile Thr 
    6815                 6820                 6825             


Thr Asp  Leu Lys Ser Phe Tyr  Ser Glu Asp Ser Gly  Ser His Cys 
    6830                 6835                 6840             


Thr Arg  Glu Cys Arg Lys Glu  Thr Leu Ile Ile Thr  Pro Pro Ser 
    6845                 6850                 6855             


Cys Lys  Ser His Lys Ser Arg  Lys Tyr Arg Ser Ser  Ser Lys Met 
    6860                 6865                 6870             


Lys Ser  Pro Asp Trp Leu Cys  His Ser Ser Ser Asn  Thr Ala Glu 
    6875                 6880                 6885             


Ile Gln  Ser Arg Ser Ser Ser  Val Ser Phe Ser Glu  Glu Lys Ile 
    6890                 6895                 6900             


Ser Trp  Thr Thr Lys Ser Arg  Thr Ser Tyr Ser Ser  Ala Pro Leu 
    6905                 6910                 6915             


Thr Glu  Ser Asn Ile Lys Ser  His Leu Ala Lys Asn  Gln Gly Lys 
    6920                 6925                 6930             


Ser His  Arg His Pro Glu Ser  Gln Glu Arg Lys Lys  Ala Arg Ser 
    6935                 6940                 6945             


Asp Leu  Phe Arg Lys Asn Ser  Ser His Trp Asp His  Asp Tyr Ser 
    6950                 6955                 6960             


Cys Thr  His Ser Lys Gly Lys  Arg Asp Arg Lys Lys  Arg Val Tyr 
    6965                 6970                 6975             


Asp Tyr  Glu Ser Glu Arg Leu  Asp Cys Phe Gln Ser  Lys His Lys 
    6980                 6985                 6990             


Ser Ala  Ser Lys Pro His His  Asp Asp Ile Asn Phe  Tyr Ser Glu 
    6995                 7000                 7005             


Arg Lys  Gln Asn Arg Pro Phe  Phe Phe Ala Cys Val  Pro Ala Asp 
    7010                 7015                 7020             


Ser Leu  Glu Val Ile Pro Lys  Thr Ile Arg Trp Thr  Ile Pro Pro 
    7025                 7030                 7035             


Glu Thr  Leu Arg Lys Arg Asn  Phe Arg Ile Pro Leu  Val Ala Lys 
    7040                 7045                 7050             


Ile Ser  Ser Ser Trp Asn Ile  Trp Ser Ser Ser Lys  Lys Leu Leu 
    7055                 7060                 7065             


Gly Ser  Leu Ser Gly Ser Leu  Thr Thr Val Phe His  Ser 
    7070                 7075                 7080     


<210>  1914
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  1914

Met Ser Arg Val Leu Gln Lys Asp Ala Glu Gln Glu Ser Gln Met Arg 
1               5                   10                  15      


Ala Glu Ile Gln Asp Met Lys Gln Glu Leu Ser Thr Val Asn Met Met 
            20                  25                  30          


Asp Glu Phe Ala Arg Tyr Ala Arg Leu Glu Arg Lys Ile Asn Lys Met 
        35                  40                  45              


Thr Asp Lys Leu Lys Thr His Val Lys Ala Arg Thr Ala Gln Leu Ala 
    50                  55                  60                  


Lys Ile Lys Trp Val Ile Ser Val Ala Phe Tyr Val Leu Gln Ala Ala 
65                  70                  75                  80  


Leu Met Ile Ser Leu Ile Trp Lys Tyr Tyr Ser Val Pro Val Ala Val 
                85                  90                  95      


Val Pro Ser Lys Trp Ile Thr Pro Leu Asp Arg Leu Val Ala Phe Pro 
            100                 105                 110         


Thr Arg Val Ala Gly Gly Val Gly Ile Thr Cys Trp Ile Leu Val Cys 
        115                 120                 125             


Asn Lys Val Val Ala Ile Val Leu His Pro Phe Ser 
    130                 135                 140 


<210>  1915
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  1915

Met Arg Arg Gly Trp Lys Met Ala Leu Ser Gly Gly Leu Arg Cys Cys 
1               5                   10                  15      


Arg Arg Val Leu Ser Trp Val Pro Val Leu Val Ile Val Leu Val Val 
            20                  25                  30          


Leu Trp Ser Tyr Tyr Ala Tyr Val Phe Glu Leu Cys Leu Val Ile Tyr 
        35                  40                  45              


Leu Ile Leu Tyr His Ala Ile Phe Val Phe Phe Thr Trp Thr Tyr Trp 
    50                  55                  60                  


Lys Ser Ile Phe Thr Leu Pro Gln Gln Pro Asn Gln Lys Phe His Leu 
65                  70                  75                  80  


Ser Tyr Thr Asp Lys Glu Arg Tyr Glu Asn Glu Glu Arg Pro Glu Val 
                85                  90                  95      


Gln Lys Gln Met Leu Val Asp Met Ala Lys Lys Leu Pro Val Tyr Thr 
            100                 105                 110         


Arg Thr Gly Ser Gly Ala Val Arg Phe Cys Asp Arg Cys His Leu Ile 
        115                 120                 125             


Lys Pro Asp Arg Cys His His Cys Ser Val Cys Ala Met Cys Val Leu 
    130                 135                 140                 


Lys Met Asp His His Cys Pro Trp Val Asn Asn Cys Ile Gly Phe Ser 
145                 150                 155                 160 


Asn Tyr Lys Phe Phe Leu Gln Phe Leu Ala Tyr Ser Val Leu Tyr Cys 
                165                 170                 175     


Leu Tyr Ile Ala Thr Thr Val Phe Ser Tyr Phe Ile Lys Tyr Trp Arg 
            180                 185                 190         


Gly Glu Leu Pro Ser Val Arg Ser Lys Phe His Val Leu Phe Leu Leu 
        195                 200                 205             


Phe Val Ala Cys Met Phe Phe Val Ser Leu Val Ile Leu Phe Gly Tyr 
    210                 215                 220                 


His Cys Trp Leu Val Ser Arg Asn Lys Thr Thr Leu Glu Ala Phe Cys 
225                 230                 235                 240 


Thr Pro Val Phe Thr Ser Gly Pro Glu Lys Asn Gly Phe Asn Leu Gly 
                245                 250                 255     


Phe Ile Lys Asn Ile Gln Gln Val Phe Gly Asp Lys Lys Lys Phe Trp 
            260                 265                 270         


Leu Ile Pro Ile Gly Ser Ser Pro Gly Asp Gly His Ser Phe Pro Met 
        275                 280                 285             


Arg Ser Met Asn Glu Ser Gln Asn Pro Leu Leu Ala Asn Glu Glu Thr 
    290                 295                 300                 


Trp Glu Asp Asn Glu Asp Asp Asn Gln Asp Tyr Pro Glu Gly Ser Ser 
305                 310                 315                 320 


Ser Leu Ala Val Glu Thr Glu Thr 
                325             


<210>  1916
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  1916

Met Arg Arg Gly Trp Lys Met Ala Leu Ser Gly Gly Leu Arg Cys Cys 
1               5                   10                  15      


Arg Arg Val Leu Ser Trp Val Pro Val Leu Val Ile Val Leu Val Val 
            20                  25                  30          


Leu Trp Ser Tyr Tyr Ala Tyr Val Phe Glu Leu Cys Leu Val Ile Tyr 
        35                  40                  45              


Leu Ile Leu Tyr His Ala Ile Phe Val Phe Phe Thr Trp Thr Tyr Trp 
    50                  55                  60                  


Lys Ser Ile Phe Thr Leu Pro Gln Gln Pro Asn Gln Lys Phe His Leu 
65                  70                  75                  80  


Ser Tyr Thr Asp Lys Glu Arg Tyr Glu Asn Glu Glu Arg Pro Glu Val 
                85                  90                  95      


Gln Lys Gln Met Leu Val Asp Met Ala Lys Lys Leu Pro Val Tyr Thr 
            100                 105                 110         


Arg Thr Gly Ser Gly Gly Gln Phe Ile Gln Arg Gln Leu Glu Arg Gln 
        115                 120                 125             


Leu Ser Lys Tyr Leu Arg Lys Ala Lys Ser Tyr Met Phe Ser Asn 
    130                 135                 140             


<210>  1917
<211>  619
<212>  PRT
<213>  Homo sapiens

<400>  1917

Met Ala Ser Ala Ser Trp Arg Leu Lys Val Glu Arg Glu Pro Val Glu 
1               5                   10                  15      


Tyr Met Asn Leu Ser Val Leu Glu Lys Ile Gly Tyr Phe Ser Val Ala 
            20                  25                  30          


Arg Leu Glu Tyr Ser Gly Thr Ile Leu Ala His Cys Asn Phe Arg Leu 
        35                  40                  45              


Leu Gly Ser Asn Asp Ser Ser Ala Ser Ala Ser Gln Val Thr Gly Thr 
    50                  55                  60                  


Thr Val Ser Pro Glu Ala Val Gly Phe Leu Ser Ala Val Gly Val Phe 
65                  70                  75                  80  


Ile Ile Leu Met Leu Leu Leu Phe Leu Tyr Ile Asn Lys Lys Phe Cys 
                85                  90                  95      


Phe Glu Asn Val Gly Gly Phe Pro Asp Leu Gly Ser Glu Tyr Ser Thr 
            100                 105                 110         


Arg Lys Asn Ser Gln Asp Lys Ile Tyr Asn Ser Tyr Met Asp Lys Asp 
        115                 120                 125             


Glu His Gly Ser Ser Ser Glu Ser Glu Asp Glu Ala Leu Gly Lys Tyr 
    130                 135                 140                 


His Glu Ala Leu Ser Arg Thr His Asn Ser Arg Leu Pro Leu Ala Asp 
145                 150                 155                 160 


Ser Arg Gln Arg Asn Tyr Ala Trp Glu Thr Arg Gln Lys Tyr Ser Pro 
                165                 170                 175     


Leu Ser Ala Glu Tyr Asp Gly Tyr Ser Ser Glu Ala Ser Ile Asp Glu 
            180                 185                 190         


Gly Asn Cys Ile Gln Arg Met Arg Arg Thr Pro Pro Leu Asp Glu Leu 
        195                 200                 205             


Gln Pro Pro Pro Tyr Gln Asp Asp Ser Gly Ser Pro His Leu Ser Cys 
    210                 215                 220                 


Thr Pro Ser Glu Ile Gly Asp Ser Lys Cys Glu Phe Ser His Cys Ser 
225                 230                 235                 240 


Asn Ser Pro Arg Cys Ser Tyr Asn Lys Cys Pro Ser Glu Gly Ser Thr 
                245                 250                 255     


Gly His Glu Ile Glu Ser Phe His Asn Lys Gly Tyr Glu Glu Asp Val 
            260                 265                 270         


Pro Ser Asp Ser Thr Ala Val Leu Ser Pro Glu Asp Met Ser Ala Gln 
        275                 280                 285             


Gly Ser Ser Ser Gln Leu Pro Lys Pro Phe Asp Pro Glu Pro Glu Ala 
    290                 295                 300                 


Lys Tyr Gly Thr Leu Asp Val Thr Phe Asp Tyr Asp Ser Gln Glu Gln 
305                 310                 315                 320 


Lys Leu Leu Val Thr Val Thr Ala Val Thr Asp Ile Pro Thr Tyr Asn 
                325                 330                 335     


Arg Thr Gly Gly Asn Ser Trp Gln Val His Leu Val Leu Leu Pro Ile 
            340                 345                 350         


Lys Lys Gln Arg Ala Lys Thr Ser Ile Gln Arg Gly Pro Cys Pro Val 
        355                 360                 365             


Phe Thr Glu Thr Phe Lys Phe Asn His Val Glu Ser Glu Met Ile Gly 
    370                 375                 380                 


Asn Tyr Ala Val Arg Phe Arg Leu Tyr Gly Val His Arg Met Lys Lys 
385                 390                 395                 400 


Glu Lys Ile Val Gly Glu Lys Ile Phe Tyr Leu Thr Lys Leu Asn Leu 
                405                 410                 415     


Gln Gly Lys Met Ser Leu Pro Val Ile Leu Glu Pro Ser Tyr Asn His 
            420                 425                 430         


Ser Gly Cys Asp Ser Gln Met Ser Val Ser Glu Met Ser Cys Ser Glu 
        435                 440                 445             


Ser Thr Ser Ser Cys Gln Ser Leu Glu His Gly Ser Val Pro Glu Ile 
    450                 455                 460                 


Leu Ile Gly Leu Leu Tyr Asn Ala Thr Thr Gly Arg Leu Ser Ala Glu 
465                 470                 475                 480 


Val Ile Lys Gly Ser His Phe Lys Asn Leu Ala Ala Asn Arg Pro Pro 
                485                 490                 495     


Asn Gly Leu Phe Cys Cys Leu Lys His Leu Ile Gly Gly Gln Val Tyr 
            500                 505                 510         


Ile Ile Arg Asp Thr Tyr Val Lys Leu Thr Leu Leu Asn Ser Met Gly 
        515                 520                 525             


Gln Glu Met Ser Lys Cys Lys Thr Ser Ile Arg Arg Gly Gln Pro Asn 
    530                 535                 540                 


Pro Val Tyr Lys Glu Thr Phe Val Phe Gln Val Ala Leu Phe Gln Leu 
545                 550                 555                 560 


Ser Asp Val Thr Leu Ile Leu Ser Val Tyr Asn Lys Arg Ser Met Lys 
                565                 570                 575     


Arg Lys Glu Met Ile Gly Trp Ile Ser Leu Gly Leu Asn Ser Ser Gly 
            580                 585                 590         


Glu Glu Glu Leu Asn His Trp Thr Glu Met Lys Glu Ser Lys Gly Gln 
        595                 600                 605             


Gln Val Cys Arg Trp His Ala Leu Leu Glu Ser 
    610                 615                 


<210>  1918
<211>  574
<212>  PRT
<213>  Homo sapiens

<400>  1918

Met Ala Ile Glu Gly Gly Glu Arg Thr Cys Gly Val His Glu Leu Ile 
1               5                   10                  15      


Cys Ile Arg Lys Val Ser Pro Glu Ala Val Gly Phe Leu Ser Ala Val 
            20                  25                  30          


Gly Val Phe Ile Ile Leu Met Leu Leu Leu Phe Leu Tyr Ile Asn Lys 
        35                  40                  45              


Lys Phe Cys Phe Glu Asn Val Gly Gly Phe Pro Asp Leu Gly Ser Glu 
    50                  55                  60                  


Tyr Ser Thr Arg Lys Asn Ser Gln Asp Lys Ile Tyr Asn Ser Tyr Met 
65                  70                  75                  80  


Asp Lys Asp Glu His Gly Ser Ser Ser Glu Ser Glu Asp Glu Ala Leu 
                85                  90                  95      


Gly Lys Tyr His Glu Ala Leu Ser Arg Thr His Asn Ser Arg Leu Pro 
            100                 105                 110         


Leu Ala Asp Ser Arg Gln Arg Asn Tyr Ala Trp Glu Thr Arg Gln Lys 
        115                 120                 125             


Tyr Ser Pro Leu Ser Ala Glu Tyr Asp Gly Tyr Ser Ser Glu Ala Ser 
    130                 135                 140                 


Ile Asp Glu Gly Asn Cys Ile Gln Arg Met Arg Arg Thr Pro Pro Leu 
145                 150                 155                 160 


Asp Glu Leu Gln Pro Pro Pro Tyr Gln Asp Asp Ser Gly Ser Pro His 
                165                 170                 175     


Leu Ser Cys Thr Pro Ser Glu Ile Gly Asp Ser Lys Cys Glu Phe Ser 
            180                 185                 190         


His Cys Ser Asn Ser Pro Arg Cys Ser Tyr Asn Lys Cys Pro Ser Glu 
        195                 200                 205             


Gly Ser Thr Gly His Glu Ile Glu Ser Phe His Asn Lys Gly Tyr Glu 
    210                 215                 220                 


Glu Asp Val Pro Ser Asp Ser Thr Ala Val Leu Ser Pro Glu Asp Met 
225                 230                 235                 240 


Ser Ala Gln Gly Ser Ser Ser Gln Leu Pro Lys Pro Phe Asp Pro Glu 
                245                 250                 255     


Pro Glu Ala Lys Tyr Gly Thr Leu Asp Val Thr Phe Asp Tyr Asp Ser 
            260                 265                 270         


Gln Glu Gln Lys Leu Leu Val Thr Val Thr Ala Val Thr Asp Ile Pro 
        275                 280                 285             


Thr Tyr Asn Arg Thr Gly Gly Asn Ser Trp Gln Val His Leu Val Leu 
    290                 295                 300                 


Leu Pro Ile Lys Lys Gln Arg Ala Lys Thr Ser Ile Gln Arg Gly Pro 
305                 310                 315                 320 


Cys Pro Val Phe Thr Glu Thr Phe Lys Phe Asn His Val Glu Ser Glu 
                325                 330                 335     


Met Ile Gly Asn Tyr Ala Val Arg Phe Arg Leu Tyr Gly Val His Arg 
            340                 345                 350         


Met Lys Lys Glu Lys Ile Val Gly Glu Lys Ile Phe Tyr Leu Thr Lys 
        355                 360                 365             


Leu Asn Leu Gln Gly Lys Met Ser Leu Pro Val Ile Leu Glu Pro Ser 
    370                 375                 380                 


Tyr Asn His Ser Gly Cys Asp Ser Gln Met Ser Val Ser Glu Met Ser 
385                 390                 395                 400 


Cys Ser Glu Ser Thr Ser Ser Cys Gln Ser Leu Glu His Gly Ser Val 
                405                 410                 415     


Pro Glu Ile Leu Ile Gly Leu Leu Tyr Asn Ala Thr Thr Gly Arg Leu 
            420                 425                 430         


Ser Ala Glu Val Ile Lys Gly Ser His Phe Lys Asn Leu Ala Ala Asn 
        435                 440                 445             


Arg Pro Pro Asn Gly Leu Phe Cys Cys Leu Lys His Leu Ile Gly Gly 
    450                 455                 460                 


Gln Val Tyr Ile Ile Arg Asp Thr Tyr Val Lys Leu Thr Leu Leu Asn 
465                 470                 475                 480 


Ser Met Gly Gln Glu Met Ser Lys Cys Lys Thr Ser Ile Arg Arg Gly 
                485                 490                 495     


Gln Pro Asn Pro Val Tyr Lys Glu Thr Phe Val Phe Gln Val Ala Leu 
            500                 505                 510         


Phe Gln Leu Ser Asp Val Thr Leu Ile Leu Ser Val Tyr Asn Lys Arg 
        515                 520                 525             


Ser Met Lys Arg Lys Glu Met Ile Gly Trp Ile Ser Leu Gly Leu Asn 
    530                 535                 540                 


Ser Ser Gly Glu Glu Glu Leu Asn His Trp Thr Glu Met Lys Glu Ser 
545                 550                 555                 560 


Lys Gly Gln Gln Val Cys Arg Trp His Ala Leu Leu Glu Ser 
                565                 570                 


<210>  1919
<211>  600
<212>  PRT
<213>  Homo sapiens

<400>  1919

Met Ala Ser Ala Ser Trp Arg Leu Lys Val Glu Arg Glu Pro Val Glu 
1               5                   10                  15      


Tyr Met Asn Leu Ser Val Leu Glu Lys Ile Gly Tyr Phe Ser Val Ala 
            20                  25                  30          


Arg Leu Glu Tyr Ser Gly Thr Ile Leu Ala His Cys Asn Phe Arg Leu 
        35                  40                  45              


Leu Gly Ser Asn Asp Ser Ser Ala Ser Ala Ser Gln Val Thr Gly Thr 
    50                  55                  60                  


Thr Val Ser Pro Glu Ala Val Gly Phe Leu Ser Ala Val Gly Val Phe 
65                  70                  75                  80  


Ile Ile Leu Met Leu Leu Leu Phe Leu Tyr Ile Asn Lys Lys Phe Cys 
                85                  90                  95      


Phe Glu Asn Val Gly Gly Phe Pro Asp Leu Gly Ser Glu Tyr Ser Thr 
            100                 105                 110         


Arg Lys Asn Ser Gln Asp Lys Ile Tyr Asn Ser Tyr Met Asp Lys Asp 
        115                 120                 125             


Glu His Gly Ser Ser Ser Glu Ser Glu Asp Glu Ala Leu Gly Lys Tyr 
    130                 135                 140                 


His Glu Ala Leu Ser Arg Thr His Asn Ser Arg Leu Pro Leu Ala Asp 
145                 150                 155                 160 


Ser Arg Gln Arg Asn Tyr Ala Trp Glu Thr Arg Gln Lys Tyr Ser Pro 
                165                 170                 175     


Leu Ser Ala Glu Tyr Asp Gly Tyr Ser Ser Glu Ala Ser Ile Asp Glu 
            180                 185                 190         


Gly Asn Cys Ile Gln Arg Met Arg Arg Thr Pro Pro Leu Asp Glu Leu 
        195                 200                 205             


Gln Pro Pro Pro Tyr Gln Asp Asp Ser Gly Ser Pro His Leu Ser Cys 
    210                 215                 220                 


Thr Pro Ser Glu Ile Gly Asp Ser Lys Cys Glu Phe Ser His Cys Ser 
225                 230                 235                 240 


Asn Ser Pro Arg Cys Ser Tyr Asn Lys Cys Pro Ser Glu Gly Ser Thr 
                245                 250                 255     


Gly His Glu Ile Glu Ser Phe His Asn Lys Gly Tyr Glu Glu Asp Val 
            260                 265                 270         


Pro Ser Asp Ser Thr Ala Val Leu Ser Pro Glu Asp Met Ser Ala Gln 
        275                 280                 285             


Gly Ser Ser Ser Gln Leu Pro Lys Pro Phe Asp Pro Glu Pro Glu Ala 
    290                 295                 300                 


Lys Tyr Gly Thr Leu Asp Val Thr Phe Asp Tyr Asp Ser Gln Glu Gln 
305                 310                 315                 320 


Lys Leu Leu Val Thr Val Thr Ala Val Thr Asp Ile Pro Thr Tyr Asn 
                325                 330                 335     


Arg Thr Gly Gly Asn Ser Trp Gln Val His Leu Val Leu Leu Pro Ile 
            340                 345                 350         


Lys Lys Gln Arg Ala Lys Thr Ser Ile Gln Arg Gly Pro Cys Pro Val 
        355                 360                 365             


Phe Thr Glu Thr Phe Lys Phe Asn His Val Glu Ser Glu Met Ile Gly 
    370                 375                 380                 


Asn Tyr Ala Val Arg Phe Arg Leu Tyr Gly Val His Arg Met Lys Lys 
385                 390                 395                 400 


Glu Lys Ile Val Gly Glu Lys Ile Phe Tyr Leu Thr Lys Leu Asn Leu 
                405                 410                 415     


Gln Gly Lys Met Ser Leu Pro Val Ile Leu Glu Pro Ser Tyr Asn His 
            420                 425                 430         


Ser Gly Cys Asp Ser Gln Met Ser Val Ser Glu Met Ser Cys Ser Glu 
        435                 440                 445             


Ser Thr Ser Ser Cys Gln Ser Leu Glu His Gly Ser Val Pro Glu Ile 
    450                 455                 460                 


Leu Ile Gly Leu Leu Tyr Asn Ala Thr Thr Gly Arg Leu Ser Ala Glu 
465                 470                 475                 480 


Val Ile Lys Gly Ser His Phe Lys Asn Leu Ala Ala Asn Arg Pro Pro 
                485                 490                 495     


Asn Thr Tyr Val Lys Leu Thr Leu Leu Asn Ser Met Gly Gln Glu Met 
            500                 505                 510         


Ser Lys Cys Lys Thr Ser Ile Arg Arg Gly Gln Pro Asn Pro Val Tyr 
        515                 520                 525             


Lys Glu Thr Phe Val Phe Gln Val Ala Leu Phe Gln Leu Ser Asp Val 
    530                 535                 540                 


Thr Leu Ile Leu Ser Val Tyr Asn Lys Arg Ser Met Lys Arg Lys Glu 
545                 550                 555                 560 


Met Ile Gly Trp Ile Ser Leu Gly Leu Asn Ser Ser Gly Glu Glu Glu 
                565                 570                 575     


Leu Asn His Trp Thr Glu Met Lys Glu Ser Lys Gly Gln Gln Val Cys 
            580                 585                 590         


Arg Trp His Ala Leu Leu Glu Ser 
        595                 600 


<210>  1920
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  1920

Met Ala Asn Tyr Ser His Ala Ala Asp Asn Ile Leu Gln Asn Leu Ser 
1               5                   10                  15      


Pro Leu Thr Ala Phe Leu Lys Leu Thr Ser Leu Gly Phe Ile Ile Gly 
            20                  25                  30          


Val Ser Val Val Gly Asn Leu Leu Ile Ser Ile Leu Leu Val Lys Asp 
        35                  40                  45              


Lys Thr Leu His Arg Ala Pro Tyr Tyr Phe Leu Leu Asp Leu Cys Cys 
    50                  55                  60                  


Ser Asp Ile Leu Arg Ser Ala Ile Cys Phe Pro Phe Val Phe Asn Ser 
65                  70                  75                  80  


Val Lys Asn Gly Ser Thr Trp Thr Tyr Gly Thr Leu Thr Cys Lys Val 
                85                  90                  95      


Ile Ala Phe Leu Gly Val Leu Ser Cys Phe His Thr Ala Phe Met Leu 
            100                 105                 110         


Phe Cys Ile Ser Val Thr Arg Tyr Leu Ala Ile Ala His His Arg Phe 
        115                 120                 125             


Tyr Thr Lys Arg Leu Thr Phe Trp Thr Cys Leu Ala Val Ile Cys Met 
    130                 135                 140                 


Val Trp Thr Leu Ser Val Ala Met Ala Phe Pro Pro Val Leu Asp Val 
145                 150                 155                 160 


Gly Thr Tyr Ser Phe Ile Arg Glu Glu Asp Gln Cys Thr Phe Gln His 
                165                 170                 175     


Arg Ser Phe Arg Ala Asn Asp Ser Leu Gly Phe Met Leu Leu Leu Ala 
            180                 185                 190         


Leu Ile Leu Leu Ala Thr Gln Leu Val Tyr Leu Lys Leu Ile Phe Phe 
        195                 200                 205             


Val His Asp Arg Arg Lys Met Lys Pro Val Gln Phe Val Ala Ala Val 
    210                 215                 220                 


Ser Gln Asn Trp Thr Phe His Gly Pro Gly Ala Ser Gly Gln Ala Ala 
225                 230                 235                 240 


Ala Asn Trp Leu Ala Gly Phe Gly Arg Gly Pro Thr Pro Pro Thr Leu 
                245                 250                 255     


Leu Gly Ile Arg Gln Asn Ala Asn Thr Thr Gly Arg Arg Arg Leu Leu 
            260                 265                 270         


Val Leu Asp Glu Phe Lys Met Glu Lys Arg Ile Ser Arg Met Phe Tyr 
        275                 280                 285             


Ile Met Thr Phe Leu Phe Leu Thr Leu Trp Gly Pro Tyr Leu Val Ala 
    290                 295                 300                 


Cys Tyr Trp Arg Val Phe Ala Arg Gly Pro Val Val Pro Gly Gly Phe 
305                 310                 315                 320 


Leu Thr Ala Ala Val Trp Met Ser Phe Ala Gln Ala Gly Ile Asn Pro 
                325                 330                 335     


Phe Val Cys Ile Phe Ser Asn Arg Glu Leu Arg Arg Cys Phe Ser Thr 
            340                 345                 350         


Thr Leu Leu Tyr Cys Arg Lys Ser Arg Leu Pro Arg Glu Pro Tyr Cys 
        355                 360                 365             


Val Ile 
    370 


<210>  1921
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  1921

Met Ala Asn Tyr Ser His Ala Ala Asp Asn Ile Leu Gln Asn Leu Ser 
1               5                   10                  15      


Pro Leu Thr Ala Phe Leu Lys Leu Thr Ser Leu Gly Phe Ile Ile Gly 
            20                  25                  30          


Val Ser Val Val Gly Asn Leu Leu Ile Ser Ile Leu Leu Val Lys Asp 
        35                  40                  45              


Lys Thr Leu His Arg Ala Pro Tyr Tyr Phe Leu Leu Asp Leu Cys Cys 
    50                  55                  60                  


Ser Asp Ile Leu Arg Ser Ala Ile Cys Phe Pro Phe Val Phe Asn Ser 
65                  70                  75                  80  


Val Lys Asn Gly Ser Thr Trp Thr Tyr Gly Thr Leu Thr Cys Lys Val 
                85                  90                  95      


Ile Ala Phe Leu Gly Val Leu Ser Cys Phe His Thr Ala Phe Met Leu 
            100                 105                 110         


Phe Cys Ile Ser Val Thr Arg Tyr Leu Ala Ile Ala His His Arg Phe 
        115                 120                 125             


Tyr Thr Lys Arg Leu Thr Phe Trp Thr Cys Leu Ala Val Ile Cys Met 
    130                 135                 140                 


Val Trp Thr Leu Ser Val Ala Met Ala Phe Pro Pro Val Leu Asp Val 
145                 150                 155                 160 


Gly Thr Tyr Ser Phe Ile Arg Glu Glu Asp Gln Cys Thr Phe Gln His 
                165                 170                 175     


Arg Ser Phe Arg Ala Asn Asp Ser Leu Gly Phe Met Leu Leu Leu Ala 
            180                 185                 190         


Leu Ile Leu Leu Ala Thr Gln Leu Val Tyr Leu Lys Leu Ile Phe Phe 
        195                 200                 205             


Val His Asp Arg Arg Lys Met Lys Pro Val Gln Phe Val Ala Ala Val 
    210                 215                 220                 


Ser Gln Asn Trp Thr Phe His Gly Pro Gly Ala Ser Gly Gln Ala Ala 
225                 230                 235                 240 


Ala Asn Trp Leu Ala Gly Phe Gly Arg Gly Pro Thr Pro Pro Thr Leu 
                245                 250                 255     


Leu Gly Ile Arg Gln Asn Ala Asn Thr Thr Gly Arg Arg Arg Leu Leu 
            260                 265                 270         


Val Leu Asp Glu Phe Lys Met Glu Lys Arg Ile Ser Arg Met Phe Tyr 
        275                 280                 285             


Ile Met Thr Phe Leu Phe Leu Thr Leu Trp Gly Pro Tyr Leu Val Ala 
    290                 295                 300                 


Cys Tyr Trp Arg Val Phe Ala Arg Gly Pro Val Val Pro Gly Gly Phe 
305                 310                 315                 320 


Leu Thr Ala Ala Val Trp Met Ser Phe Ala Gln Ala Gly Ile Asn Pro 
                325                 330                 335     


Phe Val Cys Ile Phe Ser Asn Arg Glu Leu Arg Arg Cys Phe Ser Thr 
            340                 345                 350         


Thr Leu Leu Tyr Cys Arg Lys Ser Arg Leu Pro Arg Glu Pro Tyr Cys 
        355                 360                 365             


Val Ile 
    370 


<210>  1922
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  1922

Met Ala Asn Tyr Ser His Ala Ala Asp Asn Ile Leu Gln Asn Leu Ser 
1               5                   10                  15      


Pro Leu Thr Ala Phe Leu Lys Leu Thr Ser Leu Gly Phe Ile Ile Gly 
            20                  25                  30          


Val Ser Val Val Gly Asn Leu Leu Ile Ser Ile Leu Leu Val Lys Asp 
        35                  40                  45              


Lys Thr Leu His Arg Ala Pro Tyr Tyr Phe Leu Leu Asp Leu Cys Cys 
    50                  55                  60                  


Ser Asp Ile Leu Arg Ser Ala Ile Cys Phe Pro Phe Val Phe Asn Ser 
65                  70                  75                  80  


Val Lys Asn Gly Ser Thr Trp Thr Tyr Gly Thr Leu Thr Cys Lys Val 
                85                  90                  95      


Ile Ala Phe Leu Gly Val Leu Ser Cys Phe His Thr Ala Phe Met Leu 
            100                 105                 110         


Phe Cys Ile Ser Val Thr Arg Tyr Leu Ala Ile Ala His His Arg Phe 
        115                 120                 125             


Tyr Thr Lys Arg Leu Thr Phe Trp Thr Cys Leu Ala Val Ile Cys Met 
    130                 135                 140                 


Val Trp Thr Leu Ser Val Ala Met Ala Phe Pro Pro Val Leu Asp Val 
145                 150                 155                 160 


Gly Thr Tyr Ser Phe Ile Arg Glu Glu Asp Gln Cys Thr Phe Gln His 
                165                 170                 175     


Arg Ser Phe Arg Ala Asn Asp Ser Leu Gly Phe Met Leu Leu Leu Ala 
            180                 185                 190         


Leu Ile Leu Leu Ala Thr Gln Leu Val Tyr Leu Lys Leu Ile Phe Phe 
        195                 200                 205             


Val His Asp Arg Arg Lys Met Lys Pro Val Gln Phe Val Ala Ala Val 
    210                 215                 220                 


Ser Gln Asn Trp Thr Phe His Gly Pro Gly Ala Ser Gly Gln Ala Ala 
225                 230                 235                 240 


Ala Asn Trp Leu Ala Gly Phe Gly Arg Gly Pro Thr Pro Pro Thr Leu 
                245                 250                 255     


Leu Gly Ile Arg Gln Asn Ala Asn Thr Thr Gly Arg Arg Arg Leu Leu 
            260                 265                 270         


Val Leu Asp Glu Phe Lys Met Glu Lys Arg Ile Ser Arg Met Phe Tyr 
        275                 280                 285             


Ile Met Thr Phe Leu Phe Leu Thr Leu Trp Gly Pro Tyr Leu Val Ala 
    290                 295                 300                 


Cys Tyr Trp Arg Val Phe Ala Arg Gly Pro Val Val Pro Gly Gly Phe 
305                 310                 315                 320 


Leu Thr Ala Ala Val Trp Met Ser Phe Ala Gln Ala Gly Ile Asn Pro 
                325                 330                 335     


Phe Val Cys Ile Phe Ser Asn Arg Glu Leu Arg Arg Cys Phe Ser Thr 
            340                 345                 350         


Thr Leu Leu Tyr Cys Arg Lys Ser Arg Leu Pro Arg Glu Pro Tyr Cys 
        355                 360                 365             


Val Ile 
    370 


<210>  1923
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  1923

Met Arg Ser Pro Gly Gly Ile Leu Leu Gln Ala Leu Pro Arg Leu Leu 
1               5                   10                  15      


Gln His Ala Ala Leu Pro Gly Leu Ala Glu Leu Pro Ala Arg Trp Ala 
            20                  25                  30          


Leu Pro Arg Gly Ala Gly Gly Asp Gly Pro Ala Asp Arg Leu Pro Arg 
        35                  40                  45              


Gly Gly Gly Ala Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Ala 
    50                  55                  60                  


Leu Leu Gly Ala Tyr Leu Glu Arg His Gly Pro Pro Glu Ala Ser Glu 
65                  70                  75                  80  


Leu Pro Glu Pro Gly Gly Ala Leu Ala Gly Gly Pro Gly Ser Gly Gly 
                85                  90                  95      


Gly Gly Val Val Val Gly Val Ala Glu Val Arg Asn Trp Arg Cys Cys 
            100                 105                 110         


Cys Leu Gly Ser Thr Cys Trp Cys Arg Ser Leu Val Leu Val Cys Val 
        115                 120                 125             


Leu Ala Ala Leu Cys Phe Ala Ser Leu Ala Leu Val Arg Arg Tyr Leu 
    130                 135                 140                 


His His Leu Leu Leu Trp Val Glu Ser Leu Asp Ser Leu Leu Gly Val 
145                 150                 155                 160 


Leu Leu Phe Val Val Gly Phe Ile Val Val Ser Phe Pro Cys Gly Trp 
                165                 170                 175     


Gly Tyr Ile Val Leu Asn Val Ala Ala Gly Tyr Leu Tyr Gly Phe Val 
            180                 185                 190         


Leu Gly Met Gly Leu Met Met Val Gly Val Leu Ile Gly Thr Phe Ile 
        195                 200                 205             


Ala His Val Val Cys Lys Arg Leu Leu Thr Ala Trp Val Ala Ala Arg 
    210                 215                 220                 


Ile Gln Ser Ser Glu Lys Leu Ser Ala Val Ile Arg Val Val Glu Gly 
225                 230                 235                 240 


Gly Ser Gly Leu Lys Val Val Ala Leu Ala Arg Leu Thr Pro Ile Pro 
                245                 250                 255     


Phe Gly Leu Gln Asn Ala Val Phe Ser Ile Ile Ile Ser Ile Gly Leu 
            260                 265                 270         


Met Phe Tyr Val Val His Arg Ala Gln Val Glu Leu Asn Ala Ala Ile 
        275                 280                 285             


Val Ala Cys Glu Met Glu Leu Lys Ser Ser Leu Val Lys Gly Asn Gln 
    290                 295                 300                 


Pro Asn Thr Ser Gly Ser Ser Phe Tyr Asn Lys Arg Thr Leu Thr Phe 
305                 310                 315                 320 


Ser Gly Gly Gly Ile Asn Val Val 
                325             


<210>  1924
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  1924

Met Ser Ser Cys Arg Gly Gln Lys Val Ala Gly Gly Leu Arg Val Val 
1               5                   10                  15      


Ser Pro Phe Pro Leu Cys Gln Pro Ala Gly Glu Pro Ser Gln Gly Lys 
            20                  25                  30          


Met Arg Ser Ser Cys Val Leu Leu Thr Ala Leu Val Ala Leu Ala Ala 
        35                  40                  45              


Tyr Tyr Val Tyr Ile Pro Leu Pro Gly Ser Val Ser Asp Pro Trp Lys 
    50                  55                  60                  


Leu Met Leu Leu Asp Ala Thr Phe Arg Gly Ala Gln Gln Val Ser Asn 
65                  70                  75                  80  


Leu Ile His Tyr Leu Gly Leu Ser His His Leu Leu Ala Leu Asn Phe 
                85                  90                  95      


Ile Ile Val Ser Phe Gly Lys Lys Ser Ala Trp Ser Ser Ala Gln Val 
            100                 105                 110         


Lys Val Thr Asp Thr Asp Phe Asp Gly Val Glu Val Arg Val Phe Glu 
        115                 120                 125             


Gly Pro Pro Lys Pro Glu Glu Pro Leu Lys Arg Ser Val Val Tyr Ile 
    130                 135                 140                 


His Gly Gly Gly Trp Ala Leu Ala Ser Ala Ser Ala Ser Trp Ser Pro 
145                 150                 155                 160 


Ser Asp Glu Ile Arg Tyr Tyr Asp Glu Leu Cys Thr Ala Met Ala Glu 
                165                 170                 175     


Glu Leu Asn Ala Val Ile Val Ser Ile Glu Tyr Arg Leu Val Pro Lys 
            180                 185                 190         


Val Tyr Phe Pro Glu Gln Ile His Asp Val Val Arg Ala Thr Lys Tyr 
        195                 200                 205             


Phe Leu Lys Pro Glu Val Leu Gln Lys Tyr Met Val Asp Pro Gly Arg 
    210                 215                 220                 


Ile Cys Ile Ser Gly Asp Ser Ala Gly Gly Asn Leu Ala Ala Ala Leu 
225                 230                 235                 240 


Gly Gln Gln Phe Thr Gln Asp Ala Ser Leu Lys Asn Lys Leu Lys Leu 
                245                 250                 255     


Gln Ala Leu Ile Tyr Pro Val Leu Gln Ala Leu Asp Phe Asn Thr Pro 
            260                 265                 270         


Ser Tyr Gln Gln Asn Val Asn Thr Pro Ile Leu Pro Arg Tyr Val Met 
        275                 280                 285             


Val Lys Tyr Trp Val Asp Tyr Phe Lys Gly Asn Tyr Asp Phe Val Gln 
    290                 295                 300                 


Ala Met Ile Val Asn Asn His Thr Ser Leu Asp Val Glu Glu Ala Ala 
305                 310                 315                 320 


Ala Val Arg Ala Arg Leu Asn Trp Thr Ser Leu Leu Pro Ala Ser Phe 
                325                 330                 335     


Thr Lys Asn Tyr Lys Pro Val Val Gln Thr Thr Gly Asn Ala Arg Ile 
            340                 345                 350         


Val Gln Glu Leu Pro Gln Leu Leu Asp Ala Arg Ser Ala Pro Leu Ile 
        355                 360                 365             


Ala Asp Gln Ala Val Leu Gln Leu Leu Pro Lys Thr Tyr Ile Leu Thr 
    370                 375                 380                 


Cys Glu His Asp Val Leu Arg Asp Asp Gly Ile Met Tyr Ala Lys Arg 
385                 390                 395                 400 


Leu Glu Ser Ala Gly Val Glu Val Thr Leu Asp His Phe Glu Asp Gly 
                405                 410                 415     


Phe His Gly Cys Met Ile Phe Thr Ser Trp Pro Thr Asn Phe Ser Val 
            420                 425                 430         


Gly Ile Arg Thr Arg Asn Ser Tyr Ile Lys Trp Leu Asp Gln Asn Leu 
        435                 440                 445             


<210>  1925
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  1925

Met Ala Glu Glu Leu Asn Ala Val Ile Val Ser Ile Glu Tyr Arg Leu 
1               5                   10                  15      


Val Pro Lys Val Tyr Phe Pro Glu Gln Ile His Asp Val Val Arg Ala 
            20                  25                  30          


Thr Lys Tyr Phe Leu Lys Pro Glu Val Leu Gln Lys Tyr Met Val Asp 
        35                  40                  45              


Pro Gly Arg Ile Cys Ile Ser Gly Asp Ser Ala Gly Gly Asn Leu Ala 
    50                  55                  60                  


Ala Ala Leu Gly Gln Gln Phe Thr Gln Asp Ala Ser Leu Lys Asn Lys 
65                  70                  75                  80  


Leu Lys Leu Gln Ala Leu Ile Tyr Pro Val Leu Gln Ala Leu Asp Phe 
                85                  90                  95      


Asn Thr Pro Ser Tyr Gln Gln Asn Val Asn Thr Pro Ile Leu Pro Arg 
            100                 105                 110         


Tyr Val Met Val Lys Tyr Trp Val Asp Tyr Phe Lys Gly Asn Tyr Asp 
        115                 120                 125             


Phe Val Gln Ala Met Ile Val Asn Asn His Thr Ser Leu Asp Val Glu 
    130                 135                 140                 


Glu Ala Ala Ala Val Arg Ala Arg Leu Asn Trp Thr Ser Leu Leu Pro 
145                 150                 155                 160 


Ala Ser Phe Thr Lys Asn Tyr Lys Pro Val Val Gln Thr Thr Gly Asn 
                165                 170                 175     


Ala Arg Ile Val Gln Glu Leu Pro Gln Leu Leu Asp Ala Arg Ser Ala 
            180                 185                 190         


Pro Leu Ile Ala Asp Gln Ala Val Leu Gln Leu Leu Pro Lys Thr Tyr 
        195                 200                 205             


Ile Leu Thr Cys Glu His Asp Val Leu Arg Asp Asp Gly Ile Met Tyr 
    210                 215                 220                 


Ala Lys Arg Leu Glu Ser Ala Gly Val Glu Val Thr Leu Asp His Phe 
225                 230                 235                 240 


Glu Asp Gly Phe His Gly Cys Met Ile Phe Thr Ser Trp Pro Thr Asn 
                245                 250                 255     


Phe Ser Val Gly Ile Arg Thr Arg Asn Ser Tyr Ile Lys Trp Leu Asp 
            260                 265                 270         


Gln Asn Leu 
        275 


<210>  1926
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  1926

Met Ala Glu Glu Leu Asn Ala Val Ile Val Ser Ile Glu Tyr Arg Leu 
1               5                   10                  15      


Val Pro Lys Val Tyr Phe Pro Glu Gln Ile His Asp Val Val Arg Ala 
            20                  25                  30          


Thr Lys Tyr Phe Leu Lys Pro Glu Val Leu Gln Lys Tyr Met Val Asp 
        35                  40                  45              


Pro Gly Arg Ile Cys Ile Ser Gly Asp Ser Ala Gly Gly Asn Leu Ala 
    50                  55                  60                  


Ala Ala Leu Gly Gln Gln Phe Thr Gln Asp Ala Ser Leu Lys Asn Lys 
65                  70                  75                  80  


Leu Lys Leu Gln Ala Leu Ile Tyr Pro Val Leu Gln Ala Leu Asp Phe 
                85                  90                  95      


Asn Thr Pro Ser Tyr Gln Gln Asn Val Asn Thr Pro Ile Leu Pro Arg 
            100                 105                 110         


Tyr Val Met Val Lys Tyr Trp Val Asp Tyr Phe Lys Gly Asn Tyr Asp 
        115                 120                 125             


Phe Val Gln Ala Met Ile Val Asn Asn His Thr Ser Leu Asp Val Glu 
    130                 135                 140                 


Glu Ala Ala Ala Val Arg Ala Arg Leu Asn Trp Thr Ser Leu Leu Pro 
145                 150                 155                 160 


Ala Ser Phe Thr Lys Asn Tyr Lys Pro Val Val Gln Thr Thr Gly Asn 
                165                 170                 175     


Ala Arg Ile Val Gln Glu Leu Pro Gln Leu Leu Asp Ala Arg Ser Ala 
            180                 185                 190         


Pro Leu Ile Ala Asp Gln Ala Val Leu Gln Leu Leu Pro Lys Thr Tyr 
        195                 200                 205             


Ile Leu Thr Cys Glu His Asp Val Leu Arg Asp Asp Gly Ile Met Tyr 
    210                 215                 220                 


Ala Lys Arg Leu Glu Ser Ala Gly Val Glu Val Thr Leu Asp His Phe 
225                 230                 235                 240 


Glu Asp Gly Phe His Gly Cys Met Ile Phe Thr Ser Trp Pro Thr Asn 
                245                 250                 255     


Phe Ser Val Gly Ile Arg Thr Arg Asn Ser Tyr Ile Lys Trp Leu Asp 
            260                 265                 270         


Gln Asn Leu 
        275 


<210>  1927
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  1927

Met Thr Arg Arg Gln Gln Val Leu Gln Ala Lys Arg Ser Ile Gln Gln 
1               5                   10                  15      


Thr Phe Gln Ala Gln Leu Met Pro Trp Lys Ser Met Phe His Gly Arg 
            20                  25                  30          


Glu Val Lys Pro Val Gly Pro Asp Leu Glu Leu Ser Glu Ala Glu Asn 
        35                  40                  45              


Gly Val Glu Glu Lys Lys Lys Ala Cys Arg Ser Pro Thr Ala Gln Ser 
    50                  55                  60                  


Pro Thr Pro Ser Val Glu Ala Asp Ser Pro Asp Gln Lys Lys Ile Ile 
65                  70                  75                  80  


Ser Leu Trp Ser Lys Ser Ser Phe Asp Gly Ala Ser Leu Ala Ser Asp 
                85                  90                  95      


Lys Asn Asp Cys Lys Thr Glu Ser Lys Asn Asp Pro Lys Thr Glu Arg 
            100                 105                 110         


Lys Lys Ser Ser Ser Ser Ser Gln Tyr Lys Ala Asn Met His Phe His 
        115                 120                 125             


Lys Leu Phe Leu Ser Val Pro Thr Glu Glu Pro Leu Lys Gln Ser Phe 
    130                 135                 140                 


Thr Cys Ala Leu Gln Lys Glu Ile Leu Tyr Gln Gly Lys Leu Phe Val 
145                 150                 155                 160 


Ser Glu Asn Trp Ile Cys Phe His Ser Lys Val Phe Gly Lys Asp Thr 
                165                 170                 175     


Lys Ile Ser Ile Pro Ala Phe Ser Val Thr Leu Ile Lys Lys Thr Lys 
            180                 185                 190         


Thr Ala Leu Leu Val Pro Asn Ala Leu Ile Ile Ala Thr Val Thr Asp 
        195                 200                 205             


Arg Tyr Ile Phe Val Ser Leu Leu Ser Arg Asp Ser Thr Tyr Lys Leu 
    210                 215                 220                 


Leu Lys Ser Val Cys Gly His Leu Glu Asn Thr Ser Val Gly Asn Ser 
225                 230                 235                 240 


Pro Asn Pro Ser Ser Ala Glu Asn Ser Phe Arg Ala Asp Arg Pro Ser 
                245                 250                 255     


Ser Leu Pro Leu Asp Phe Asn Asp Glu Phe Ser Asp Leu Asp Gly Val 
            260                 265                 270         


Val Gln Gln Arg Arg Gln Asp Met Glu Gly Tyr Ser Ser Ser Gly Ser 
        275                 280                 285             


Gln Thr Pro Glu Ser Glu Asn Ser Arg Asp Phe His Ala Thr Glu Ser 
    290                 295                 300                 


Gln Thr Val Leu Asn Val Ser Lys Gly Glu Ala Lys Pro Thr Arg Ala 
305                 310                 315                 320 


Asp Ala His Val Asn Arg Val Pro Glu Gly Lys Ala Lys Ser Leu Pro 
                325                 330                 335     


Val Gln Gly Leu Ser Glu Thr Val Gly Ile Leu His Lys Val Lys Ser 
            340                 345                 350         


Gln Lys Cys Pro Met Leu His His Ile Leu Ile Phe Tyr Ala Ile Val 
        355                 360                 365             


Val Cys Ala Leu Ile Ile Ser Thr Phe Tyr Met Arg Tyr Arg Ile Asn 
    370                 375                 380                 


Thr Leu Glu Glu Gln Leu Gly Leu Leu Thr Ser Ile Val Asp Thr His 
385                 390                 395                 400 


Asn Thr Glu Gln Ala Ala Pro Ser Gly Leu Arg Ser Gln Val Gln Phe 
                405                 410                 415     


Asn Val Glu Val Leu Cys Gln Glu Leu Thr Ala Asn Ile Val Lys Leu 
            420                 425                 430         


Glu Lys Ile Gln Asn Asn Leu Gln Lys Leu Leu Glu Asn Gly Asp 
        435                 440                 445         


<210>  1928
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  1928

Met Tyr Lys Ala Asn Met His Phe His Lys Leu Phe Leu Ser Val Pro 
1               5                   10                  15      


Thr Glu Glu Pro Leu Lys Gln Ser Phe Thr Cys Ala Leu Gln Lys Glu 
            20                  25                  30          


Ile Leu Tyr Gln Gly Lys Leu Phe Val Ser Glu Asn Trp Ile Cys Phe 
        35                  40                  45              


His Ser Lys Val Phe Gly Lys Asp Thr Lys Ile Ser Ile Pro Ala Phe 
    50                  55                  60                  


Ser Val Thr Leu Ile Lys Lys Thr Lys Thr Ala Leu Leu Val Pro Asn 
65                  70                  75                  80  


Ala Leu Ile Ile Ala Thr Val Thr Asp Arg Tyr Ile Phe Val Ser Leu 
                85                  90                  95      


Leu Ser Arg Asp Ser Thr Tyr Lys Leu Leu Lys Ser Val Cys Gly His 
            100                 105                 110         


Leu Glu Asn Thr Ser Val Gly Asn Ser Pro Asn Pro Ser Ser Ala Glu 
        115                 120                 125             


Asn Ser Phe Arg Ala Asp Arg Pro Ser Ser Leu Pro Leu Asp Phe Asn 
    130                 135                 140                 


Asp Glu Phe Ser Asp Leu Asp Gly Val Val Gln Gln Arg Arg Gln Asp 
145                 150                 155                 160 


Met Glu Gly Tyr Ser Ser Ser Gly Ser Gln Thr Pro Glu Ser Glu Asn 
                165                 170                 175     


Ser Arg Asp Phe His Ala Thr Glu Ser Gln Thr Val Leu Asn Val Ser 
            180                 185                 190         


Lys Gly Glu Ala Lys Pro Thr Arg Ala Asp Ala His Val Asn Arg Val 
        195                 200                 205             


Pro Glu Gly Lys Ala Lys Ser Leu Pro Val Gln Gly Leu Ser Glu Thr 
    210                 215                 220                 


Val Gly Ile Leu His Lys Val Lys Ser Gln Lys Cys Pro Met Leu His 
225                 230                 235                 240 


His Ile Leu Ile Phe Tyr Ala Ile Val Val Cys Ala Leu Ile Ile Ser 
                245                 250                 255     


Thr Phe Tyr Met Arg Tyr Arg Ile Asn Thr Leu Glu Glu Gln Leu Gly 
            260                 265                 270         


Leu Leu Thr Ser Ile Val Asp Thr His Asn Thr Glu Gln Ala Ala Pro 
        275                 280                 285             


Ser Gly Leu Arg Ser Gln Val Gln Phe Asn Val Glu Val Leu Cys Gln 
    290                 295                 300                 


Glu Leu Thr Ala Asn Ile Val Lys Leu Glu Lys Ile Gln Asn Asn Leu 
305                 310                 315                 320 


Gln Lys Leu Leu Glu Asn Gly Asp 
                325             


<210>  1929
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  1929

Met Trp Lys Thr Gln Ser Leu Arg Lys Cys Ser Gly Arg Gly Arg Ala 
1               5                   10                  15      


Asn Leu Ala Gln Pro Thr Gln Arg Leu Arg Met Val Trp Arg Arg Lys 
            20                  25                  30          


Arg Lys Pro Ala Gly Arg Gln Gln Pro Asn Pro Leu Pro His Leu Trp 
        35                  40                  45              


Arg Arg Thr Pro Gln Thr Arg Arg Lys Ser Leu Ala Tyr Ala His Ile 
    50                  55                  60                  


Phe Ser Pro Asn Leu Cys Phe Ile Gln Asp Gln Glu Ser Lys Ser Ser 
65                  70                  75                  80  


Phe Asp Gly Ala Ser Leu Ala Ser Asp Lys Asn Asp Cys Lys Thr Glu 
                85                  90                  95      


Ser Lys Asn Asp Pro Lys Thr Glu Arg Lys Lys Ser Ser Ser Ser Ser 
            100                 105                 110         


Gln Tyr Lys Ala Asn Met His Phe His Lys Leu Phe Leu Ser Val Pro 
        115                 120                 125             


Thr Glu Glu Pro Leu Lys Gln Ser Phe Thr Cys Ala Leu Gln Lys Glu 
    130                 135                 140                 


Ile Leu Tyr Gln Gly Lys Leu Phe Val Ser Glu Asn Trp Ile Cys Phe 
145                 150                 155                 160 


His Ser Lys Val Phe Gly Lys Asp Thr Lys Ile Ser Ile Pro Ala Phe 
                165                 170                 175     


Ser Val Thr Leu Ile Lys Lys Thr Lys Thr Ala Leu Leu Val Pro Asn 
            180                 185                 190         


Ala Leu Ile Ile Ala Thr Val Thr Asp Arg Tyr Ile Phe Val Ser Leu 
        195                 200                 205             


Leu Ser Arg Asp Ser Thr Tyr Lys Leu Leu Lys Ser Val Cys Gly His 
    210                 215                 220                 


Leu Glu Asn Thr Ser Val Gly Asn Ser Pro Asn Pro Ser Ser Ala Glu 
225                 230                 235                 240 


Asn Ser Phe Arg Ala Asp Arg Pro Ser Ser Leu Pro Leu Asp Phe Asn 
                245                 250                 255     


Asp Glu Phe Ser Asp Leu Asp Gly Val Val Gln Gln Arg Arg Gln Asp 
            260                 265                 270         


Met Glu Gly Tyr Ser Ser Ser Gly Ser Gln Thr Pro Glu Ser Glu Asn 
        275                 280                 285             


Ser Arg Asp Phe His Ala Thr Glu Ser Gln Thr Val Leu Asn Val Ser 
    290                 295                 300                 


Lys Gly Glu Ala Lys Pro Thr Arg Ala Asp Ala His Val Asn Arg Val 
305                 310                 315                 320 


Pro Glu Gly Lys Ala Lys Ser Leu Pro Val Gln Gly Leu Ser Glu Thr 
                325                 330                 335     


Val Gly Ile Leu His Lys Val Lys Ser Gln Lys Cys Pro Met Leu His 
            340                 345                 350         


His Ile Leu Ile Phe Tyr Ala Ile Val Val Cys Ala Leu Ile Ile Ser 
        355                 360                 365             


Thr Phe Tyr Met Arg Tyr Arg Ile Asn Thr Leu Glu Glu Gln Leu Gly 
    370                 375                 380                 


Leu Leu Thr Ser Ile Val Asp Thr His Asn Thr Glu Gln Ala Ala Pro 
385                 390                 395                 400 


Ser Gly Leu Arg Ser Gln Val Gln Phe Asn Val Glu Val Leu Cys Gln 
                405                 410                 415     


Glu Leu Thr Ala Asn Ile Val Lys Leu Glu Lys Ile Gln Asn Asn Leu 
            420                 425                 430         


Gln Lys Leu Leu Glu Asn Gly Asp 
        435                 440 


<210>  1930
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  1930

Met Ser Lys Val Lys Arg Phe Pro Phe Phe Phe Ser Ser Glu Ala Glu 
1               5                   10                  15      


Asn Gly Val Glu Glu Lys Lys Lys Ala Cys Arg Ser Pro Thr Ala Gln 
            20                  25                  30          


Ser Pro Thr Pro Ser Val Glu Ala Asp Ser Pro Asp Gln Lys Lys Ile 
        35                  40                  45              


Ile Ser Leu Trp Ser Lys Ser Ser Phe Asp Gly Ala Ser Leu Ala Ser 
    50                  55                  60                  


Asp Lys Asn Asp Cys Lys Thr Glu Ser Lys Asn Asp Pro Lys Thr Glu 
65                  70                  75                  80  


Arg Lys Lys Ser Ser Ser Ser Ser Gln Tyr Lys Ala Asn Met His Phe 
                85                  90                  95      


His Lys Leu Phe Leu Ser Val Pro Thr Glu Glu Pro Leu Lys Gln Ser 
            100                 105                 110         


Phe Thr Cys Ala Leu Gln Lys Glu Ile Leu Tyr Gln Gly Lys Leu Phe 
        115                 120                 125             


Val Ser Glu Asn Trp Ile Cys Phe His Ser Lys Val Phe Gly Lys Asp 
    130                 135                 140                 


Thr Lys Ile Ser Ile Pro Ala Phe Ser Val Thr Leu Ile Lys Lys Thr 
145                 150                 155                 160 


Lys Thr Ala Leu Leu Val Pro Asn Ala Leu Ile Ile Ala Thr Val Thr 
                165                 170                 175     


Asp Arg Tyr Ile Phe Val Ser Leu Leu Ser Arg Asp Ser Thr Tyr Lys 
            180                 185                 190         


Leu Leu Lys Ser Val Cys Gly His Leu Glu Asn Thr Ser Val Gly Asn 
        195                 200                 205             


Ser Pro Asn Pro Ser Ser Ala Glu Asn Ser Phe Arg Ala Asp Arg Pro 
    210                 215                 220                 


Ser Ser Leu Pro Leu Asp Phe Asn Asp Glu Phe Ser Asp Leu Asp Gly 
225                 230                 235                 240 


Val Val Gln Gln Arg Arg Gln Asp Met Glu Gly Tyr Ser Ser Ser Gly 
                245                 250                 255     


Ser Gln Thr Pro Glu Ser Glu Asn Ser Arg Asp Phe His Ala Thr Glu 
            260                 265                 270         


Ser Gln Thr Val Leu Asn Val Ser Lys Gly Glu Ala Lys Pro Thr Arg 
        275                 280                 285             


Ala Asp Ala His Val Asn Arg Val Pro Glu Gly Lys Ala Lys Ser Leu 
    290                 295                 300                 


Pro Val Gln Gly Leu Ser Glu Thr Val Gly Ile Leu His Lys Val Lys 
305                 310                 315                 320 


Ser Gln Lys Cys Pro Met Leu His His Ile Leu Ile Phe Tyr Ala Ile 
                325                 330                 335     


Val Val Cys Ala Leu Ile Ile Ser Thr Phe Tyr Met Arg Tyr Arg Ile 
            340                 345                 350         


Asn Thr Leu Glu Glu Gln Leu Gly Leu Leu Thr Ser Ile Val Asp Thr 
        355                 360                 365             


His Asn Thr Glu Gln Ala Ala Pro Ser Gly Leu Arg Ser Gln Val Gln 
    370                 375                 380                 


Phe Asn Val Glu Val Leu Cys Gln Glu Leu Thr Ala Asn Ile Val Lys 
385                 390                 395                 400 


Leu Glu Lys Ile Gln Asn Asn Leu Gln Lys Leu Leu Glu Asn Gly Asp 
                405                 410                 415     


<210>  1931
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  1931

Met Phe Gly Trp Ser Phe Val Phe Glu Asp Phe Val Ser Asp Glu Leu 
1               5                   10                  15      


Arg Asn Lys Ala Thr Gln Pro Met Lys Ser Val Leu Trp Trp Leu Pro 
            20                  25                  30          


Val Glu Lys Ala Phe Trp Arg Gln Pro Ala Gly Pro Gly Ser Gly Ile 
        35                  40                  45              


Arg Glu Arg Leu Glu His Pro Val Leu His Val Ser Trp Asn Asp Ala 
    50                  55                  60                  


Arg Ala Tyr Cys Ala Trp Arg Gly Lys Arg Leu Pro Thr Glu Glu Glu 
65                  70                  75                  80  


Trp Glu Phe Ala Ala Arg Gly Gly Leu Lys Gly Gln Val Tyr Pro Trp 
                85                  90                  95      


Gly Asn Trp Phe Gln Pro Asn Arg Thr Asn Leu Trp Gln Gly Lys Phe 
            100                 105                 110         


Pro Lys Gly Asp Lys Ala Glu Asp Gly Phe His Gly Val Ser Pro Val 
        115                 120                 125             


Asn Ala Phe Pro Ala Gln Asn Asn Tyr Gly Leu Tyr Asp Leu Leu Gly 
    130                 135                 140                 


Asn Val Trp Glu Trp Thr Ala Ser Pro Tyr Gln Ala Ala Glu Gln Asp 
145                 150                 155                 160 


Met Arg Val Leu Arg Gly Ala Ser Trp Ile Asp Thr Ala Asp Gly Ser 
                165                 170                 175     


Ala Asn His Arg Ala Arg Val Thr Thr Arg Met Gly Asn Thr Pro Asp 
            180                 185                 190         


Ser Ala Ser Asp Asn Leu Gly Phe Arg Cys Ala Ala Asp Ala Gly Arg 
        195                 200                 205             


Pro Pro Gly Glu Leu 
    210             


<210>  1932
<211>  623
<212>  PRT
<213>  Homo sapiens

<400>  1932

Met Val Ile Gly Ile Pro Leu Phe Phe Leu Glu Leu Ser Val Gly Gln 
1               5                   10                  15      


Arg Ile Arg Arg Gly Ser Ile Gly Val Trp Asn Tyr Ile Ser Pro Lys 
            20                  25                  30          


Leu Gly Gly Ile Gly Phe Ala Ser Cys Val Val Cys Tyr Phe Val Ala 
        35                  40                  45              


Leu Tyr Tyr Asn Val Ile Ile Gly Trp Ser Leu Phe Tyr Phe Ser Gln 
    50                  55                  60                  


Ser Phe Gln Gln Pro Leu Pro Trp Asp Gln Cys Pro Leu Val Lys Asn 
65                  70                  75                  80  


Ala Ser His Thr Phe Val Glu Pro Glu Cys Glu Gln Ser Ser Ala Thr 
                85                  90                  95      


Thr Tyr Tyr Trp Tyr Arg Glu Ala Leu Asn Ile Ser Ser Ser Ile Ser 
            100                 105                 110         


Glu Ser Gly Gly Leu Asn Trp Lys Met Thr Ile Cys Leu Leu Ala Ala 
        115                 120                 125             


Trp Val Met Val Cys Leu Ala Met Ile Lys Gly Ile Gln Ser Ser Gly 
    130                 135                 140                 


Lys Ile Ile Tyr Phe Ser Ser Leu Phe Pro Tyr Val Val Leu Ile Cys 
145                 150                 155                 160 


Phe Leu Ile Arg Ala Phe Leu Leu Asn Gly Ser Ile Asp Gly Ile Arg 
                165                 170                 175     


His Met Phe Thr Pro Lys Leu Glu Ile Met Leu Glu Pro Lys Val Trp 
            180                 185                 190         


Arg Glu Ala Ala Thr Gln Val Phe Phe Ala Leu Gly Leu Gly Phe Gly 
        195                 200                 205             


Gly Val Ile Ala Phe Ser Ser Tyr Asn Lys Arg Asp Asn Asn Cys His 
    210                 215                 220                 


Phe Asp Ala Val Leu Val Ser Phe Ile Asn Phe Phe Thr Ser Val Leu 
225                 230                 235                 240 


Ala Thr Leu Val Val Phe Ala Val Leu Gly Phe Lys Ala Asn Val Ile 
                245                 250                 255     


Asn Glu Lys Cys Ile Thr Gln Asn Ser Glu Thr Ile Met Lys Phe Leu 
            260                 265                 270         


Lys Met Gly Asn Ile Ser Gln Asp Ile Ile Pro His His Ile Asn Leu 
        275                 280                 285             


Ser Thr Val Thr Ala Glu Asp Tyr His Leu Val Tyr Asp Ile Ile Gln 
    290                 295                 300                 


Lys Val Lys Glu Glu Glu Phe Pro Ala Leu His Leu Asn Ser Cys Lys 
305                 310                 315                 320 


Ile Glu Glu Glu Leu Asn Lys Ala Val Gln Gly Thr Gly Leu Ala Phe 
                325                 330                 335     


Ile Ala Phe Thr Glu Ala Met Thr His Phe Pro Ala Ser Pro Phe Trp 
            340                 345                 350         


Ser Val Met Phe Phe Leu Met Leu Val Asn Leu Gly Leu Gly Ser Met 
        355                 360                 365             


Phe Gly Thr Ile Glu Gly Ile Val Thr Pro Ile Val Asp Thr Phe Lys 
    370                 375                 380                 


Val Arg Lys Glu Ile Leu Thr Val Ile Cys Cys Leu Leu Ala Phe Cys 
385                 390                 395                 400 


Ile Gly Leu Ile Phe Val Gln Arg Ser Gly Asn Tyr Phe Val Thr Met 
                405                 410                 415     


Phe Asp Asp Tyr Ser Ala Thr Leu Pro Leu Leu Ile Val Val Ile Leu 
            420                 425                 430         


Glu Asn Ile Ala Val Cys Phe Val Tyr Gly Ile Asp Lys Phe Met Glu 
        435                 440                 445             


Asp Leu Lys Asp Met Leu Gly Phe Ala Pro Ser Arg Tyr Tyr Tyr Tyr 
    450                 455                 460                 


Met Trp Lys Tyr Ile Ser Pro Leu Met Leu Leu Ser Leu Leu Ile Ala 
465                 470                 475                 480 


Ser Val Val Asn Met Gly Leu Ser Pro Pro Gly Tyr Asn Ala Trp Ile 
                485                 490                 495     


Glu Asp Lys Ala Ser Glu Glu Phe Leu Ser Tyr Pro Thr Trp Gly Leu 
            500                 505                 510         


Val Val Cys Val Ser Leu Val Val Phe Ala Ile Leu Pro Val Pro Val 
        515                 520                 525             


Val Phe Ile Val Arg Arg Phe Asn Leu Ile Asp Asp Ser Ser Gly Asn 
    530                 535                 540                 


Leu Ala Ser Val Thr Tyr Lys Arg Gly Arg Val Leu Lys Glu Pro Val 
545                 550                 555                 560 


Asn Leu Glu Gly Asp Asp Thr Ser Leu Ile His Gly Lys Ile Pro Ser 
                565                 570                 575     


Glu Met Pro Ser Pro Asn Phe Gly Lys Asn Ile Tyr Arg Lys Gln Ser 
            580                 585                 590         


Gly Ser Pro Thr Leu Asp Thr Ala Pro Asn Gly Arg Tyr Gly Ile Gly 
        595                 600                 605             


Tyr Leu Met Ala Asp Ile Met Pro Asp Met Pro Glu Ser Asp Leu 
    610                 615                 620             


<210>  1933
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  1933

Met Glu Ala Glu Gly Leu Asp Trp Leu Leu Val Pro Leu His Gln Leu 
1               5                   10                  15      


Val Ser Trp Gly Ala Ala Ala Ala Met Val Phe Gly Gly Val Val Pro 
            20                  25                  30          


Tyr Val Pro Gln Tyr Arg Asp Ile Arg Arg Thr Gln Asn Ala Asp Gly 
        35                  40                  45              


Phe Ser Thr Tyr Val Cys Leu Val Leu Leu Val Ala Asn Ile Leu Arg 
    50                  55                  60                  


Ile Leu Phe Trp Phe Gly Arg Arg Phe Glu Ser Pro Leu Leu Trp Gln 
65                  70                  75                  80  


Ser Ala Ile Met Ile Leu Thr Met Leu Leu Met Leu Lys Leu Cys Thr 
                85                  90                  95      


Glu Val Arg Val Ala Asn Glu Leu Asn Ala Arg Arg Arg Ser Phe Thr 
            100                 105                 110         


Ala Ser Arg Trp Cys Ser Cys Gly Pro Val Val Thr Pro Ser Arg Arg 
        115                 120                 125             


Pro Thr Ser Cys 
    130         


<210>  1934
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  1934

Met Glu Ala Glu Gly Leu Asp Trp Leu Leu Val Pro Leu His Gln Leu 
1               5                   10                  15      


Val Ser Trp Gly Ala Ala Ala Ala Met Val Phe Gly Gly Val Val Pro 
            20                  25                  30          


Tyr Val Pro Gln Tyr Arg Asp Ile Arg Arg Thr Gln Asn Ala Asp Gly 
        35                  40                  45              


Phe Ser Thr Tyr Val Cys Leu Val Leu Leu Val Ala Asn Ile Leu Arg 
    50                  55                  60                  


Ile Leu Phe Trp Phe Gly Arg Arg Phe Glu Ser Pro Leu Leu Trp Gln 
65                  70                  75                  80  


Ser Ala Ile Met Ile Leu Thr Met Leu Leu Met Leu Lys Leu Cys Thr 
                85                  90                  95      


Glu Val Arg Val Ala Asn Glu Leu Asn Ala Arg Arg Arg Ser Phe Thr 
            100                 105                 110         


Asp Phe Asp Pro His His Phe Trp Gln Trp Ser Ser Phe Ser Asp Tyr 
        115                 120                 125             


Val Gln Cys Val Leu Ala Phe Thr Gly Val Ala Gly Tyr Ile Thr Tyr 
    130                 135                 140                 


Leu Ser Ile Asp Ser Ala Leu Phe Val Glu Thr Leu Gly Phe Leu Ala 
145                 150                 155                 160 


Val Leu Thr Glu Ala Met Leu Gly Val Pro Gln Leu Tyr Arg Asn His 
                165                 170                 175     


Arg His Gln Ser Thr Glu Gly Met Ser Ile Lys Met Val Leu Met Trp 
            180                 185                 190         


Thr Ser Gly Asp Ala Phe Lys Thr Ala Tyr Phe Leu Leu Lys Gly Ala 
        195                 200                 205             


Pro Leu Gln Phe Ser Val Cys Gly Leu Leu Gln Val Leu Val Asp Leu 
    210                 215                 220                 


Ala Ile Leu Gly Gln Ala Tyr Ala Phe Ala Arg His Pro Gln Lys Pro 
225                 230                 235                 240 


Ala Pro His Ala Val His Pro Thr Gly Thr Lys Ala Leu 
                245                 250             


<210>  1935
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  1935

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Ala Ser Asp 
                245                 250                 255     


Thr Ala Val Pro Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp 
            260                 265                 270         


Gly Ile Pro Met Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu 
        275                 280                 285             


Met Ile Ile Ala Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val 
    290                 295                 300                 


Ala Phe Leu Leu Arg Gly Lys Leu Met Glu Thr Tyr Cys Ser Gln Lys 
305                 310                 315                 320 


His Thr Arg Leu Asp Tyr Ile Gly Asp Ser Lys Asn Val Leu Asn Asp 
                325                 330                 335     


Val Gln His Gly Arg Glu Asp Glu Asp Gly Leu Phe Thr Leu 
            340                 345                 350 


<210>  1936
<211>  967
<212>  PRT
<213>  Homo sapiens

<400>  1936

Met Ala Lys Gly Phe Tyr Ile Ser Lys Ser Leu Gly Ile Leu Gly Ile 
1               5                   10                  15      


Leu Leu Gly Val Ala Ala Val Cys Thr Ile Ile Ala Leu Ser Val Val 
            20                  25                  30          


Tyr Ser Gln Glu Lys Asn Lys Asn Ala Asn Ser Ser Pro Val Ala Ser 
        35                  40                  45              


Thr Thr Pro Ser Ala Ser Ala Thr Thr Asn Pro Ala Ser Ala Thr Thr 
    50                  55                  60                  


Leu Asp Gln Ser Lys Ala Trp Asn Arg Tyr Arg Leu Pro Asn Thr Leu 
65                  70                  75                  80  


Lys Pro Asp Ser Tyr Arg Val Thr Leu Arg Pro Tyr Leu Thr Pro Asn 
                85                  90                  95      


Asp Arg Gly Leu Tyr Val Phe Lys Gly Ser Ser Thr Val Arg Phe Thr 
            100                 105                 110         


Cys Lys Glu Ala Thr Asp Val Ile Ile Ile His Ser Lys Lys Leu Asn 
        115                 120                 125             


Tyr Thr Leu Ser Gln Gly His Arg Val Val Leu Arg Gly Val Gly Gly 
    130                 135                 140                 


Ser Gln Pro Pro Asp Ile Asp Lys Thr Glu Leu Val Glu Pro Thr Glu 
145                 150                 155                 160 


Tyr Leu Val Val His Leu Lys Gly Ser Leu Val Lys Asp Ser Gln Tyr 
                165                 170                 175     


Glu Met Asp Ser Glu Phe Glu Gly Glu Leu Ala Asp Asp Leu Ala Gly 
            180                 185                 190         


Phe Tyr Arg Ser Glu Tyr Met Glu Gly Asn Val Arg Lys Val Val Ala 
        195                 200                 205             


Thr Thr Gln Met Gln Ala Ala Asp Ala Arg Lys Ser Phe Pro Cys Phe 
    210                 215                 220                 


Asp Glu Pro Ala Met Lys Ala Glu Phe Asn Ile Thr Leu Ile His Pro 
225                 230                 235                 240 


Lys Asp Leu Thr Ala Leu Ser Asn Met Leu Pro Lys Gly Pro Ser Thr 
                245                 250                 255     


Pro Leu Pro Glu Asp Pro Asn Trp Asn Val Thr Glu Phe His Thr Thr 
            260                 265                 270         


Pro Lys Met Ser Thr Tyr Leu Leu Ala Phe Ile Val Ser Glu Phe Asp 
        275                 280                 285             


Tyr Val Glu Lys Gln Ala Ser Asn Gly Val Leu Ile Arg Ile Trp Ala 
    290                 295                 300                 


Arg Pro Ser Ala Ile Ala Ala Gly His Gly Asp Tyr Ala Leu Asn Val 
305                 310                 315                 320 


Thr Gly Pro Ile Leu Asn Phe Phe Ala Gly His Tyr Asp Thr Pro Tyr 
                325                 330                 335     


Pro Leu Pro Lys Ser Asp Gln Ile Gly Leu Pro Asp Phe Asn Ala Gly 
            340                 345                 350         


Ala Met Glu Asn Trp Gly Leu Val Thr Tyr Arg Glu Asn Ser Leu Leu 
        355                 360                 365             


Phe Asp Pro Leu Ser Ser Ser Ser Ser Asn Lys Glu Arg Val Val Thr 
    370                 375                 380                 


Val Ile Ala His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr 
385                 390                 395                 400 


Ile Glu Trp Trp Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Ser Tyr 
                405                 410                 415     


Val Glu Tyr Leu Gly Ala Asp Tyr Ala Glu Pro Thr Trp Asn Leu Lys 
            420                 425                 430         


Asp Leu Met Val Leu Asn Asp Val Tyr Arg Val Met Ala Val Asp Ala 
        435                 440                 445             


Leu Ala Ser Ser His Pro Leu Ser Thr Pro Ala Ser Glu Ile Asn Thr 
    450                 455                 460                 


Pro Ala Gln Ile Ser Glu Leu Phe Asp Ala Ile Ser Tyr Ser Lys Gly 
465                 470                 475                 480 


Ala Ser Val Leu Arg Met Leu Ser Ser Phe Leu Ser Glu Asp Val Phe 
                485                 490                 495     


Lys Gln Gly Leu Ala Ser Tyr Leu His Thr Phe Ala Tyr Gln Asn Thr 
            500                 505                 510         


Ile Tyr Leu Asn Leu Trp Asp His Leu Gln Glu Ala Val Asn Asn Arg 
        515                 520                 525             


Ser Ile Gln Leu Pro Thr Thr Val Arg Asp Ile Met Asn Arg Trp Thr 
    530                 535                 540                 


Leu Gln Met Gly Phe Pro Val Ile Thr Val Asp Thr Ser Thr Gly Thr 
545                 550                 555                 560 


Leu Ser Gln Glu His Phe Leu Leu Asp Pro Asp Ser Asn Val Thr Arg 
                565                 570                 575     


Pro Ser Glu Phe Asn Tyr Val Trp Ile Val Pro Ile Thr Ser Ile Arg 
            580                 585                 590         


Asp Gly Arg Gln Gln Gln Asp Tyr Trp Leu Ile Asp Val Arg Ala Gln 
        595                 600                 605             


Asn Asp Leu Phe Ser Thr Ser Gly Asn Glu Trp Val Leu Leu Asn Leu 
    610                 615                 620                 


Asn Val Thr Gly Tyr Tyr Arg Val Asn Tyr Asp Glu Glu Asn Trp Arg 
625                 630                 635                 640 


Lys Ile Gln Thr Gln Leu Gln Arg Asp His Ser Ala Ile Pro Val Ile 
                645                 650                 655     


Asn Arg Ala Gln Ile Ile Asn Asp Ala Phe Asn Leu Ala Ser Ala His 
            660                 665                 670         


Lys Val Pro Val Thr Leu Ala Leu Asn Asn Thr Leu Phe Leu Ile Glu 
        675                 680                 685             


Glu Arg Gln Tyr Met Pro Trp Glu Ala Ala Leu Ser Ser Leu Ser Tyr 
    690                 695                 700                 


Phe Lys Leu Met Phe Asp Arg Ser Glu Val Tyr Gly Pro Met Lys Asn 
705                 710                 715                 720 


Tyr Leu Lys Lys Gln Val Thr Pro Leu Phe Ile His Phe Arg Asn Asn 
                725                 730                 735     


Thr Asn Asn Trp Arg Glu Ile Pro Glu Asn Leu Met Asp Gln Tyr Ser 
            740                 745                 750         


Glu Val Asn Ala Ile Ser Thr Ala Cys Ser Asn Gly Val Pro Glu Cys 
        755                 760                 765             


Glu Glu Met Val Ser Gly Leu Phe Lys Gln Trp Met Glu Asn Pro Asn 
    770                 775                 780                 


Asn Asn Pro Ile His Pro Asn Leu Arg Ser Thr Val Tyr Cys Asn Ala 
785                 790                 795                 800 


Ile Ala Gln Gly Gly Glu Glu Glu Trp Asp Phe Ala Trp Glu Gln Phe 
                805                 810                 815     


Arg Asn Ala Thr Leu Val Asn Glu Ala Asp Lys Leu Arg Ala Ala Leu 
            820                 825                 830         


Ala Cys Ser Lys Glu Leu Trp Ile Leu Asn Arg Tyr Leu Ser Tyr Thr 
        835                 840                 845             


Leu Asn Pro Asp Leu Ile Arg Lys Gln Asp Ala Thr Ser Thr Ile Ile 
    850                 855                 860                 


Ser Ile Thr Asn Asn Val Ile Gly Gln Gly Leu Val Trp Asp Phe Val 
865                 870                 875                 880 


Gln Ser Asn Trp Lys Lys Leu Phe Asn Asp Tyr Gly Gly Gly Ser Phe 
                885                 890                 895     


Ser Phe Ser Asn Leu Ile Gln Ala Val Thr Arg Arg Phe Ser Thr Glu 
            900                 905                 910         


Tyr Glu Leu Gln Gln Leu Glu Gln Phe Lys Lys Asp Asn Glu Glu Thr 
        915                 920                 925             


Gly Phe Gly Ser Gly Thr Arg Ala Leu Glu Gln Ala Leu Glu Lys Thr 
    930                 935                 940                 


Lys Ala Asn Ile Lys Trp Val Lys Glu Asn Lys Glu Val Val Leu Gln 
945                 950                 955                 960 


Trp Phe Thr Glu Asn Ser Lys 
                965         


<210>  1937
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  1937

Met Gly Asp His Ala Trp Ser Phe Leu Lys Asp Phe Leu Ala Gly Gly 
1               5                   10                  15      


Val Ala Ala Ala Val Ser Lys Thr Ala Val Ala Pro Ile Glu Arg Val 
            20                  25                  30          


Lys Leu Leu Leu Gln Val Gln His Ala Ser Lys Gln Ile Ser Ala Glu 
        35                  40                  45              


Lys Gln Tyr Lys Gly Ile Ile Asp Cys Val Val Arg Ile Pro Lys Glu 
    50                  55                  60                  


Gln Gly Phe Leu Ser Phe Trp Arg Gly Asn Leu Ala Asn Val Ile Arg 
65                  70                  75                  80  


Tyr Phe Pro Thr Gln Ala Leu Asn Phe Ala Phe Lys Asp Lys Tyr Lys 
                85                  90                  95      


Gln Leu Phe Leu Gly Gly Val Asp Arg His Lys Gln Phe Trp Arg Tyr 
            100                 105                 110         


Phe Ala Gly Asn Leu Ala Ser Gly Gly Ala Ala Gly Ala Thr Ser Leu 
        115                 120                 125             


Cys Phe Val Tyr Pro Leu Asp Phe Ala Arg Thr Arg Leu Ala Ala Asp 
    130                 135                 140                 


Val Gly Lys Gly Ala Ala Gln Arg Glu Phe His Gly Leu Gly Asp Cys 
145                 150                 155                 160 


Ile Ile Lys Ile Phe Lys Ser Asp Gly Leu Arg Gly Leu Tyr Gln Gly 
                165                 170                 175     


Phe Asn Val Ser Val Gln Gly Ile Ile Ile Tyr Arg Ala Ala Tyr Phe 
            180                 185                 190         


Gly Val Tyr Asp Thr Ala Lys Gly Met Leu Pro Asp Pro Lys Asn Val 
        195                 200                 205             


His Ile Phe Val Ser Trp Met Ile Ala Gln Ser Val Thr Ala Val Ala 
    210                 215                 220                 


Gly Leu Val Ser Tyr Pro Phe Asp Thr Val Arg Arg Arg Met Met Met 
225                 230                 235                 240 


Gln Ser Gly Arg Lys Gly Ala Asp Ile Met Tyr Thr Gly Thr Val Asp 
                245                 250                 255     


Cys Trp Arg Lys Ile Ala Lys Asp Glu Gly Ala Lys Ala Phe Phe Lys 
            260                 265                 270         


Gly Ala Trp Ser Asn Val Leu Arg Gly Met Gly Gly Ala Phe Val Leu 
        275                 280                 285             


Val Leu Tyr Asp Glu Ile Lys Lys Tyr Val 
    290                 295             


<210>  1938
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  1938

Met Thr Asp Ala Ala Val Ser Phe Ala Lys Asp Phe Leu Ala Gly Gly 
1               5                   10                  15      


Val Ala Ala Ala Ile Ser Lys Thr Ala Val Ala Pro Ile Glu Arg Val 
            20                  25                  30          


Lys Leu Leu Leu Gln Val Gln His Ala Ser Lys Gln Ile Thr Ala Asp 
        35                  40                  45              


Lys Gln Tyr Lys Gly Ile Ile Asp Cys Val Val Arg Ile Pro Lys Glu 
    50                  55                  60                  


Gln Gly Val Leu Ser Phe Trp Arg Gly Asn Leu Ala Asn Val Ile Arg 
65                  70                  75                  80  


Tyr Phe Pro Thr Gln Ala Leu Asn Phe Ala Phe Lys Asp Lys Tyr Lys 
                85                  90                  95      


Gln Ile Phe Leu Gly Gly Val Asp Lys Arg Thr Gln Phe Trp Leu Tyr 
            100                 105                 110         


Phe Ala Gly Asn Leu Ala Ser Gly Gly Ala Ala Gly Ala Thr Ser Leu 
        115                 120                 125             


Cys Phe Val Tyr Pro Leu Asp Phe Ala Arg Thr Arg Leu Ala Ala Asp 
    130                 135                 140                 


Val Gly Lys Ala Gly Ala Glu Arg Glu Phe Arg Gly Leu Gly Asp Cys 
145                 150                 155                 160 


Leu Val Lys Ile Tyr Lys Ser Asp Gly Ile Lys Gly Leu Tyr Gln Gly 
                165                 170                 175     


Phe Asn Val Ser Val Gln Gly Ile Ile Ile Tyr Arg Ala Ala Tyr Phe 
            180                 185                 190         


Gly Ile Tyr Asp Thr Ala Lys Gly Met Leu Pro Asp Pro Lys Asn Thr 
        195                 200                 205             


His Ile Val Ile Ser Trp Met Ile Ala Gln Thr Val Thr Ala Val Ala 
    210                 215                 220                 


Gly Leu Thr Ser Tyr Pro Phe Asp Thr Val Arg Arg Arg Met Met Met 
225                 230                 235                 240 


Gln Ser Gly Arg Lys Gly Thr Asp Ile Met Tyr Thr Gly Thr Leu Asp 
                245                 250                 255     


Cys Trp Arg Lys Ile Ala Arg Asp Glu Gly Gly Lys Ala Phe Phe Lys 
            260                 265                 270         


Gly Ala Trp Ser Asn Val Leu Arg Gly Met Gly Gly Ala Phe Val Leu 
        275                 280                 285             


Val Leu Tyr Asp Glu Ile Lys Lys Tyr Thr 
    290                 295             


<210>  1939
<211>  506
<212>  PRT
<213>  Homo sapiens

<400>  1939

Met Thr Ser Gly Gly Ser Arg Phe Leu Trp Leu Leu Lys Ile Leu Val 
1               5                   10                  15      


Ile Ile Leu Val Leu Gly Ile Val Gly Phe Met Phe Gly Ser Met Phe 
            20                  25                  30          


Leu Gln Ala Val Phe Ser Ser Pro Lys Pro Glu Leu Pro Ser Pro Ala 
        35                  40                  45              


Pro Gly Val Gln Lys Leu Lys Leu Leu Pro Glu Glu Arg Leu Arg Asn 
    50                  55                  60                  


Leu Phe Ser Tyr Asp Gly Ile Trp Leu Phe Pro Lys Asn Gln Cys Lys 
65                  70                  75                  80  


Cys Glu Ala Asn Lys Glu Gln Gly Gly Tyr Asn Phe Gln Asp Ala Tyr 
                85                  90                  95      


Gly Gln Ser Asp Leu Pro Ala Val Lys Ala Arg Arg Gln Ala Glu Phe 
            100                 105                 110         


Glu His Phe Gln Arg Arg Glu Gly Leu Pro Arg Pro Leu Pro Leu Leu 
        115                 120                 125             


Val Gln Pro Asn Leu Pro Phe Gly Tyr Pro Val His Gly Val Glu Val 
    130                 135                 140                 


Met Pro Leu His Thr Val Pro Ile Pro Gly Leu Gln Phe Glu Gly Pro 
145                 150                 155                 160 


Asp Ala Pro Val Tyr Glu Val Thr Leu Thr Ala Ser Leu Gly Thr Leu 
                165                 170                 175     


Asn Thr Leu Ala Asp Val Pro Asp Ser Val Val Gln Gly Arg Gly Gln 
            180                 185                 190         


Lys Gln Leu Ile Ile Ser Thr Ser Asp Arg Lys Leu Leu Lys Phe Ile 
        195                 200                 205             


Leu Gln His Val Thr Tyr Thr Ser Thr Gly Tyr Gln His Gln Lys Val 
    210                 215                 220                 


Asp Ile Val Ser Leu Glu Ser Arg Ser Ser Val Ala Lys Phe Pro Val 
225                 230                 235                 240 


Thr Ile Arg His Pro Val Ile Pro Lys Leu Tyr Asp Pro Gly Pro Glu 
                245                 250                 255     


Arg Lys Leu Arg Asn Leu Val Thr Ile Ala Thr Lys Thr Phe Leu Arg 
            260                 265                 270         


Pro His Lys Leu Met Ile Met Leu Arg Ser Ile Arg Glu Tyr Tyr Pro 
        275                 280                 285             


Asp Leu Thr Val Ile Val Ala Asp Asp Ser Gln Lys Pro Leu Glu Ile 
    290                 295                 300                 


Lys Asp Asn His Val Glu Tyr Tyr Thr Met Pro Phe Gly Lys Gly Trp 
305                 310                 315                 320 


Phe Ala Gly Arg Asn Leu Ala Ile Ser Gln Val Thr Thr Lys Tyr Val 
                325                 330                 335     


Leu Trp Val Asp Asp Asp Phe Leu Phe Asn Glu Glu Thr Lys Ile Glu 
            340                 345                 350         


Val Leu Val Asp Val Leu Glu Lys Thr Glu Leu Asp Val Val Gly Gly 
        355                 360                 365             


Ser Val Leu Gly Asn Val Phe Gln Phe Lys Leu Leu Leu Glu Gln Ser 
    370                 375                 380                 


Glu Asn Gly Ala Cys Leu His Lys Arg Met Gly Phe Phe Gln Pro Leu 
385                 390                 395                 400 


Asp Gly Phe Pro Ser Cys Val Val Thr Ser Gly Val Val Asn Phe Phe 
                405                 410                 415     


Leu Ala His Thr Glu Arg Leu Gln Arg Val Gly Phe Asp Pro Arg Leu 
            420                 425                 430         


Gln Arg Val Ala His Ser Glu Phe Phe Ile Asp Gly Leu Gly Thr Leu 
        435                 440                 445             


Leu Val Gly Ser Cys Pro Glu Val Ile Ile Gly His Gln Ser Arg Ser 
    450                 455                 460                 


Pro Val Val Asp Ser Glu Leu Ala Ala Leu Glu Lys Thr Tyr Asn Thr 
465                 470                 475                 480 


Tyr Arg Ser Asn Thr Leu Thr Arg Val Gln Phe Lys Leu Ala Leu His 
                485                 490                 495     


Tyr Phe Lys Asn His Leu Gln Cys Ala Ala 
            500                 505     


<210>  1940
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  1940

Met Phe Gly Ser Met Phe Leu Gln Ala Val Phe Ser Ser Pro Lys Pro 
1               5                   10                  15      


Glu Leu Pro Ser Pro Ala Pro Gly Val Gln Lys Leu Lys Leu Leu Pro 
            20                  25                  30          


Glu Glu Arg Leu Arg Asn Leu Phe Ser Tyr Asp Gly Ile Trp Leu Phe 
        35                  40                  45              


Pro Lys Asn Gln Cys Lys Cys Glu Ala Asn Lys Glu Gln Gly Gly Tyr 
    50                  55                  60                  


Asn Phe Gln Asp Ala Tyr Gly Gln Ser Asp Leu Pro Ala Val Lys Ala 
65                  70                  75                  80  


Arg Arg Gln Ala Glu Phe Glu His Phe Gln Arg Arg Glu Gly Leu Pro 
                85                  90                  95      


Arg Pro Leu Pro Leu Leu Val Gln Pro Asn Leu Pro Phe Gly Tyr Pro 
            100                 105                 110         


Val His Gly Val Glu Val Met Pro Leu His Thr Val Pro Ile Pro Gly 
        115                 120                 125             


Leu Gln Phe Glu Gly Pro Asp Ala Pro Val Tyr Glu Val Thr Leu Thr 
    130                 135                 140                 


Ala Ser Leu Gly Thr Leu Asn Thr Leu Ala Asp Val Pro Asp Ser Val 
145                 150                 155                 160 


Val Gln Gly Arg Gly Gln Lys Gln Leu Ile Ile Ser Thr Ser Asp Arg 
                165                 170                 175     


Lys Leu Leu Lys Phe Ile Leu Gln His Val Thr Tyr Thr Ser Thr Gly 
            180                 185                 190         


Tyr Gln His Gln Lys Val Asp Ile Val Ser Leu Glu Ser Arg Ser Ser 
        195                 200                 205             


Val Ala Lys Phe Pro Val Thr Ile Arg His Pro Val Ile Pro Lys Leu 
    210                 215                 220                 


Tyr Asp Pro Gly Pro Glu Arg Lys Leu Arg Asn Leu Val Thr Ile Ala 
225                 230                 235                 240 


Thr Lys Thr Phe Leu Arg Pro His Lys Leu Met Ile Met Leu Arg Ser 
                245                 250                 255     


Ile Arg Glu Tyr Tyr Pro Asp Leu Thr Val Ile Val Ala Asp Asp Ser 
            260                 265                 270         


Gln Lys Pro Leu Glu Ile Lys Asp Asn His Val Glu Tyr Tyr Thr Met 
        275                 280                 285             


Pro Phe Gly Lys Gly Trp Phe Ala Gly Arg Asn Leu Ala Ile Ser Gln 
    290                 295                 300                 


Val Thr Thr Lys Tyr Val Leu Trp Val Asp Asp Asp Phe Leu Phe Asn 
305                 310                 315                 320 


Glu Glu Thr Lys Ile Glu Val Leu Val Asp Val Leu Glu Lys Thr Glu 
                325                 330                 335     


Leu Asp Val Val Gly Gly Ser Val Leu Gly Asn Val Phe Gln Phe Lys 
            340                 345                 350         


Leu Leu Leu Glu Gln Ser Glu Asn Gly Ala Cys Leu His Lys Arg Met 
        355                 360                 365             


Gly Phe Phe Gln Pro Leu Asp Gly Phe Pro Ser Cys Val Val Thr Ser 
    370                 375                 380                 


Gly Val Val Asn Phe Phe Leu Ala His Thr Glu Arg Leu Gln Arg Val 
385                 390                 395                 400 


Gly Phe Asp Pro Arg Leu Gln Arg Val Ala His Ser Glu Phe Phe Ile 
                405                 410                 415     


Asp Gly Leu Gly Thr Leu Leu Val Gly Ser Cys Pro Glu Val Ile Ile 
            420                 425                 430         


Gly His Gln Ser Arg Ser Pro Val Val Asp Ser Glu Leu Ala Ala Leu 
        435                 440                 445             


Glu Lys Thr Tyr Asn Thr Tyr Arg Ser Asn Thr Leu Thr Arg Val Gln 
    450                 455                 460                 


Phe Lys Leu Ala Leu His Tyr Phe Lys Asn His Leu Gln Cys Ala Ala 
465                 470                 475                 480 


<210>  1941
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  1941

Met Leu Pro Arg Leu Leu Leu Leu Ile Cys Ala Pro Leu Cys Glu Pro 
1               5                   10                  15      


Ala Glu Leu Phe Leu Ile Ala Ser Pro Ser His Pro Thr Glu Gly Ser 
            20                  25                  30          


Pro Val Thr Leu Thr Cys Lys Met Pro Phe Leu Gln Ser Ser Asp Ala 
        35                  40                  45              


Gln Phe Gln Phe Cys Phe Phe Arg Asp Thr Arg Ala Leu Gly Pro Gly 
    50                  55                  60                  


Trp Ser Ser Ser Pro Lys Leu Gln Ile Ala Ala Met Trp Lys Glu Asp 
65                  70                  75                  80  


Thr Gly Ser Tyr Trp Cys Glu Ala Gln Thr Met Ala Ser Lys Val Leu 
                85                  90                  95      


Arg Ser Arg Arg Ser Gln Ile Asn Val His Arg Val Pro Val Ala Asp 
            100                 105                 110         


Val Ser Leu Glu Thr Gln Pro Pro Gly Gly Gln Val Met Glu Gly Asp 
        115                 120                 125             


Arg Leu Val Leu Ile Cys Ser Val Ala Met Gly Thr Gly Asp Ile Thr 
    130                 135                 140                 


Phe Leu Trp Tyr Lys Gly Ala Val Gly Leu Asn Leu Gln Ser Lys Thr 
145                 150                 155                 160 


Gln Arg Ser Leu Thr Ala Glu Tyr Glu Ile Pro Ser Val Arg Glu Ser 
                165                 170                 175     


Asp Ala Glu Gln Tyr Tyr Cys Val Ala Glu Asn Gly Tyr Gly Pro Ser 
            180                 185                 190         


Pro Ser Gly Leu Val Ser Ile Thr Val Arg Ile Pro Val Ser Arg Pro 
        195                 200                 205             


Ile Leu Met Leu Arg Ala Pro Arg Ala Gln Ala Ala Val Glu Asp Val 
    210                 215                 220                 


Leu Glu Leu His Cys Glu Ala Leu Arg Gly Ser Pro Pro Ile Leu Tyr 
225                 230                 235                 240 


Trp Phe Tyr His Glu Asp Ile Thr Leu Gly Ser Arg Ser Ala Pro Ser 
                245                 250                 255     


Gly Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Glu Glu His Ser Gly 
            260                 265                 270         


Asn Tyr Ser Cys Glu Ala Asn Asn Gly Leu Gly Ala Gln Arg Ser Glu 
        275                 280                 285             


Ala Val Thr Leu Asn Phe Thr Gly Arg Arg Ser Ala Arg Asp Pro Leu 
    290                 295                 300                 


Arg Ser Leu Pro Ser Pro Leu Pro Gln Glu Phe Thr Tyr Leu Asn Ser 
305                 310                 315                 320 


Pro Thr Pro Gly Gln Leu Gln Pro Ile Tyr Glu Asn Glu Pro Arg Glu 
                325                 330                 335     


Gln Ser Val Ala Val His Gly Arg Gln Gln His Ser Ser Glu Gln Lys 
            340                 345                 350         


Ala Gln Lys Pro Trp Gly His Ile Trp Arg Thr Arg Phe Pro 
        355                 360                 365     


<210>  1942
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  1942

Met Leu Pro Arg Leu Leu Leu Leu Ile Cys Ala Pro Leu Cys Glu Pro 
1               5                   10                  15      


Ala Glu Leu Phe Leu Ile Ala Ser Pro Ser His Pro Thr Glu Gly Ser 
            20                  25                  30          


Pro Val Thr Leu Thr Cys Lys Met Pro Phe Leu Gln Ser Ser Asp Ala 
        35                  40                  45              


Gln Phe Gln Phe Cys Phe Phe Arg Asp Thr Arg Ala Leu Gly Pro Gly 
    50                  55                  60                  


Trp Ser Ser Ser Pro Lys Leu Gln Ile Ala Ala Met Trp Lys Glu Asp 
65                  70                  75                  80  


Thr Gly Ser Tyr Trp Cys Glu Ala Gln Thr Met Ala Ser Lys Val Leu 
                85                  90                  95      


Arg Ser Arg Arg Ser Gln Ile Asn Val His Arg Val Pro Val Ala Asp 
            100                 105                 110         


Val Ser Leu Glu Thr Gln Pro Pro Gly Gly Gln Val Met Glu Gly Asp 
        115                 120                 125             


Arg Leu Val Leu Ile Cys Ser Val Ala Met Gly Thr Gly Asp Ile Thr 
    130                 135                 140                 


Phe Leu Trp Tyr Lys Gly Ala Val Gly Leu Asn Leu Gln Ser Lys Thr 
145                 150                 155                 160 


Gln Arg Ser Leu Thr Ala Glu Tyr Glu Ile Pro Ser Val Arg Glu Ser 
                165                 170                 175     


Asp Ala Glu Gln Tyr Tyr Cys Val Ala Glu Asn Gly Tyr Gly Pro Ser 
            180                 185                 190         


Pro Ser Gly Leu Val Ser Ile Thr Val Arg Ile Pro Val Ser Arg Pro 
        195                 200                 205             


Ile Leu Met Leu Arg Ala Pro Arg Ala Gln Ala Ala Val Glu Asp Val 
    210                 215                 220                 


Leu Glu Leu His Cys Glu Ala Leu Arg Gly Ser Pro Pro Ile Leu Tyr 
225                 230                 235                 240 


Trp Phe Tyr His Glu Asp Ile Thr Leu Gly Ser Arg Ser Ala Pro Ser 
                245                 250                 255     


Gly Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Glu Glu His Ser Gly 
            260                 265                 270         


Asn Tyr Ser Cys Glu Ala Asn Asn Gly Leu Gly Ala Gln Arg Ser Glu 
        275                 280                 285             


Ala Val Thr Leu Asn Phe Thr Val Pro Thr Gly Ala Arg Ser Asn His 
    290                 295                 300                 


Leu Thr Ser Gly Val Ile Glu Gly Leu Leu Ser Thr Leu Gly Pro Ala 
305                 310                 315                 320 


Thr Val Ala Leu Leu Phe Cys Tyr Gly Leu Lys Arg Lys Ile Gly Arg 
                325                 330                 335     


Arg Ser Ala Arg Asp Pro Leu Arg Ser Leu Pro Ser Pro Leu Pro Gln 
            340                 345                 350         


Glu Phe Thr Tyr Leu Asn Ser Pro Thr Pro Gly Gln Leu Gln Pro Ile 
        355                 360                 365             


Tyr Glu Asn Val Asn Val Val Ser Gly Asp Glu Val Tyr Ser Leu Ala 
    370                 375                 380                 


Tyr Tyr Asn Gln Pro Glu Gln Glu Ser Val Ala Glu Thr Leu Gly Thr 
385                 390                 395                 400 


His Met Glu Asp Lys Val Ser Leu Asp Ile Tyr Ser Arg Leu Arg Lys 
                405                 410                 415     


Ala Asn Ile Thr Asp Val Asp Tyr Glu Asp Ala Met 
            420                 425             


<210>  1943
<211>  1736
<212>  PRT
<213>  Homo sapiens

<400>  1943

Met Thr Gly Cys Pro Ala Ser Ser Arg Arg Arg Gly Phe Gly Leu Phe 
1               5                   10                  15      


Phe Phe Leu Arg Leu His Arg Leu Leu Leu Leu Phe Leu Val Leu Arg 
            20                  25                  30          


Gly Thr Leu Ala Asn Lys Leu Asn Val Pro Gln Val Leu Leu Pro Phe 
        35                  40                  45              


Gly Arg Glu Pro Gly Arg Val Pro Phe Leu Leu Glu Ala Gln Arg Gly 
    50                  55                  60                  


Cys Tyr Thr Trp His Ser Thr His His Asp Ala Val Thr Val Glu Pro 
65                  70                  75                  80  


Leu Tyr Glu Asn Gly Thr Leu Cys Ser Gln Lys Ala Val Leu Ile Ala 
                85                  90                  95      


Glu Ser Thr Gln Pro Ile Arg Leu Ser Ser Ile Ile Leu Ala Arg Glu 
            100                 105                 110         


Ile Val Thr Asp His Glu Leu Arg Cys Asp Val Lys Val Asp Val Ile 
        115                 120                 125             


Asn Ser Ile Glu Ile Val Ser Arg Ala Arg Glu Leu Tyr Val Asp Asp 
    130                 135                 140                 


Ser Pro Leu Glu Leu Met Val Arg Ala Leu Asp Ala Glu Gly Asn Thr 
145                 150                 155                 160 


Phe Ser Ser Leu Ala Gly Met Met Phe Glu Trp Ser Ile Ala Gln Asp 
                165                 170                 175     


Asn Glu Ser Ala Arg Glu Glu Leu Ser Ser Lys Ile Arg Ile Leu Lys 
            180                 185                 190         


Tyr Ser Glu Ala Glu Tyr Ala Pro Pro Ile Tyr Ile Ala Glu Met Glu 
        195                 200                 205             


Lys Glu Glu Lys Gln Gly Asp Val Ile Leu Val Ser Gly Ile Arg Thr 
    210                 215                 220                 


Gly Ala Ala Val Val Lys Val Arg Ile His Glu Pro Phe Tyr Lys Lys 
225                 230                 235                 240 


Val Ala Ala Ala Leu Ile Arg Leu Leu Val Leu Glu Asn Ile Phe Leu 
                245                 250                 255     


Ile Pro Ser His Asp Ile Tyr Leu Leu Val Gly Thr Tyr Ile Lys Tyr 
            260                 265                 270         


Gln Val Ala Lys Met Val Gln Gly Arg Val Thr Glu Val Lys Phe Pro 
        275                 280                 285             


Leu Glu His Tyr Ile Leu Glu Leu Gln Asp His Arg Val Ala Leu Asn 
    290                 295                 300                 


Gly Ser His Ser Glu Lys Val Ala Ile Leu Asp Asp Lys Thr Ala Met 
305                 310                 315                 320 


Val Thr Ala Ser Gln Leu Gly Gln Thr Asn Leu Val Phe Val His Lys 
                325                 330                 335     


Asn Val His Met Arg Ser Val Ser Gly Leu Pro Asn Cys Thr Ile Tyr 
            340                 345                 350         


Val Val Glu Pro Gly Phe Leu Gly Phe Thr Val Gln Pro Gly Asn Arg 
        355                 360                 365             


Trp Ser Leu Glu Val Gly Gln Val Tyr Val Ile Thr Val Asp Val Phe 
    370                 375                 380                 


Asp Lys Ser Ser Thr Lys Val Tyr Ile Ser Asp Asn Leu Arg Ile Thr 
385                 390                 395                 400 


Tyr Asp Phe Pro Lys Glu Tyr Phe Glu Glu Gln Leu Thr Thr Val Asn 
                405                 410                 415     


Gly Ser Tyr His Ile Val Lys Ala Leu Lys Asp Gly Val Val Val Ile 
            420                 425                 430         


Asn Ala Ser Leu Thr Ser Ile Ile Tyr Gln Asn Lys Asp Ile Gln Pro 
        435                 440                 445             


Ile Lys Phe Leu Ile Lys His Gln Gln Glu Val Lys Ile Tyr Phe Pro 
    450                 455                 460                 


Ile Met Leu Thr Pro Lys Phe Leu Ala Phe Pro His His Pro Met Gly 
465                 470                 475                 480 


Met Leu Tyr Arg Tyr Lys Val Gln Val Glu Gly Gly Ser Gly Asn Phe 
                485                 490                 495     


Thr Trp Thr Ser Ser Asn Glu Thr Val Val Ile Val Thr Thr Lys Gly 
            500                 505                 510         


Val Val Thr Ala Gly Gln Val Arg Gly Asn Ser Thr Val Leu Ala Arg 
        515                 520                 525             


Asp Val Gln Asn Pro Phe Arg Tyr Gly Glu Ile Lys Ile His Val Leu 
    530                 535                 540                 


Lys Leu Asn Lys Met Glu Leu Leu Pro Phe His Ala Asp Val Glu Ile 
545                 550                 555                 560 


Gly Gln Ile Ile Glu Ile Pro Ile Ala Met Tyr His Ile Asn Lys Glu 
                565                 570                 575     


Thr Lys Glu Ala Met Ala Phe Thr Asp Cys Ser His Leu Ser Leu Asp 
            580                 585                 590         


Leu Asn Met Asp Lys Gln Gly Val Phe Thr Leu Leu Lys Glu Gly Ile 
        595                 600                 605             


Gln Arg Pro Gly Pro Met His Cys Ser Ser Thr His Ile Ala Ala Lys 
    610                 615                 620                 


Ser Leu Gly His Thr Leu Val Thr Val Ser Val Asn Glu Cys Asp Lys 
625                 630                 635                 640 


Tyr Leu Glu Ser Ser Ala Thr Phe Ala Ala Tyr Glu Pro Leu Lys Ala 
                645                 650                 655     


Leu Asn Pro Val Glu Val Ala Leu Val Thr Trp Gln Ser Val Lys Glu 
            660                 665                 670         


Met Val Phe Glu Gly Gly Pro Arg Pro Trp Ile Leu Glu Pro Ser Arg 
        675                 680                 685             


Phe Phe Leu Glu Leu Asn Ala Glu Lys Thr Glu Lys Ile Gly Ile Ala 
    690                 695                 700                 


Gln Val Trp Leu Pro Ser Lys Arg Lys Gln Asn Gln Tyr Ile Tyr Arg 
705                 710                 715                 720 


Ile Gln Cys Leu Asp Leu Gly Glu Gln Val Leu Thr Phe Arg Ile Gly 
                725                 730                 735     


Asn His Pro Gly Val Leu Asn Pro Ser Pro Ala Val Glu Val Leu Gln 
            740                 745                 750         


Val Arg Phe Ile Cys Ala His Pro Ala Ser Met Ser Val Thr Pro Val 
        755                 760                 765             


Tyr Lys Val Pro Ala Gly Ala Gln Pro Cys Pro Leu Pro Gln His Asn 
    770                 775                 780                 


Lys Trp Leu Ile Pro Val Ser Arg Leu Arg Asp Thr Val Leu Glu Leu 
785                 790                 795                 800 


Ala Val Phe Asp Gln His Arg Arg Lys Phe Asp Asn Phe Ser Ser Leu 
                805                 810                 815     


Met Leu Glu Trp Lys Ser Ser Asn Glu Thr Leu Ala His Phe Glu Asp 
            820                 825                 830         


Tyr Lys Ser Val Glu Met Val Ala Lys Asp Asp Gly Ser Gly Gln Thr 
        835                 840                 845             


Arg Leu His Gly His Gln Ile Leu Lys Val His Gln Ile Lys Gly Thr 
    850                 855                 860                 


Val Leu Ile Gly Val Asn Phe Val Gly Tyr Ser Glu Lys Lys Ser Pro 
865                 870                 875                 880 


Lys Glu Ile Ser Asn Leu Pro Arg Ser Val Asp Val Glu Leu Leu Leu 
                885                 890                 895     


Val Asp Asp Val Thr Val Val Pro Glu Asn Ala Thr Ile Tyr Asn His 
            900                 905                 910         


Pro Asp Val Lys Glu Thr Phe Ser Leu Val Glu Gly Ser Gly Tyr Phe 
        915                 920                 925             


Leu Val Asn Ser Ser Glu Gln Gly Val Val Thr Ile Thr Tyr Met Glu 
    930                 935                 940                 


Ala Glu Ser Ser Val Glu Leu Val Pro Leu His Pro Gly Phe Phe Thr 
945                 950                 955                 960 


Leu Glu Val Tyr Asp Leu Cys Leu Ala Phe Leu Gly Pro Ala Thr Ala 
                965                 970                 975     


His Leu Arg Val Ser Asp Ile Gln Glu Leu Glu Leu Asp Leu Ile Asp 
            980                 985                 990         


Lys Val Glu Ile Asp Lys Thr Val  Leu Val Thr Val Arg  Val Leu Gly 
        995                 1000                 1005             


Ser Ser  Lys Arg Pro Phe Gln  Asn Lys Tyr Phe Arg  Asn Met Glu 
    1010                 1015                 1020             


Leu Lys  Leu Gln Leu Ala Ser  Ala Ile Val Thr Leu  Thr Pro Met 
    1025                 1030                 1035             


Glu Gln  Gln Asp Glu Tyr Ser  Glu Asn Tyr Ile Leu  Arg Ala Thr 
    1040                 1045                 1050             


Thr Ile  Gly Gln Thr Thr Leu  Val Ala Ile Ala Lys  Asp Lys Met 
    1055                 1060                 1065             


Gly Arg  Lys Tyr Thr Ser Thr  Pro Arg His Ile Glu  Val Phe Pro 
    1070                 1075                 1080             


Pro Phe  Arg Leu Leu Pro Glu  Lys Met Thr Leu Ile  Pro Met Asn 
    1085                 1090                 1095             


Met Met  Gln Val Met Ser Glu  Gly Gly Pro Gln Pro  Gln Ser Ile 
    1100                 1105                 1110             


Val His  Phe Ser Ile Ser Asn  Gln Thr Val Ala Val  Val Asn Arg 
    1115                 1120                 1125             


Arg Gly  Gln Val Thr Gly Lys  Ile Val Gly Thr Ala  Val Val His 
    1130                 1135                 1140             


Gly Thr  Ile Gln Thr Val Asn  Glu Asp Thr Gly Lys  Val Ile Val 
    1145                 1150                 1155             


Phe Ser  Gln Asp Glu Val Gln  Ile Glu Val Val Gln  Leu Arg Ala 
    1160                 1165                 1170             


Val Arg  Ile Leu Ala Ala Ala  Thr Arg Leu Ile Thr  Ala Thr Lys 
    1175                 1180                 1185             


Met Pro  Val Tyr Val Met Gly  Val Thr Ser Thr Gln  Thr Pro Phe 
    1190                 1195                 1200             


Ser Phe  Ser Asn Ala Asn Pro  Gly Leu Thr Phe His  Trp Ser Met 
    1205                 1210                 1215             


Ser Lys  Arg Asp Val Leu Asp  Leu Val Pro Arg His  Ser Glu Val 
    1220                 1225                 1230             


Phe Leu  Gln Leu Pro Val Glu  His Asn Phe Ala Met  Val Val His 
    1235                 1240                 1245             


Thr Lys  Ala Ala Gly Arg Thr  Ser Ile Lys Val Thr  Val His Cys 
    1250                 1255                 1260             


Met Asn  Ser Ser Ser Gly Gln  Phe Glu Gly Asn Leu  Leu Glu Leu 
    1265                 1270                 1275             


Ser Asp  Glu Val Gln Ile Leu  Val Phe Glu Lys Leu  Gln Leu Phe 
    1280                 1285                 1290             


Tyr Pro  Glu Cys Gln Pro Glu  Gln Ile Leu Met Pro  Ile Asn Ser 
    1295                 1300                 1305             


Gln Leu  Lys Leu His Thr Asn  Arg Glu Gly Ala Ala  Phe Val Ser 
    1310                 1315                 1320             


Ser Arg  Val Leu Lys Cys Phe  Pro Asn Ser Ser Val  Ile Glu Glu 
    1325                 1330                 1335             


Asp Gly  Glu Gly Leu Leu Lys  Ala Gly Ser Ile Ala  Gly Thr Ala 
    1340                 1345                 1350             


Val Leu  Glu Val Thr Ser Ile  Glu Pro Phe Gly Val  Asn Gln Thr 
    1355                 1360                 1365             


Thr Ile  Thr Gly Val Gln Val  Ala Pro Val Thr Tyr  Leu Arg Val 
    1370                 1375                 1380             


Ser Ser  Gln Pro Lys Leu Tyr  Thr Ala Gln Gly Arg  Thr Leu Ser 
    1385                 1390                 1395             


Ala Phe  Pro Leu Gly Met Ser  Leu Thr Phe Thr Val  Gln Phe Tyr 
    1400                 1405                 1410             


Asn Ser  Ile Gly Glu Lys Phe  His Thr His Asn Thr  Gln Leu Tyr 
    1415                 1420                 1425             


Leu Ala  Leu Asn Arg Asp Asp  Leu Leu His Ile Gly  Pro Gly Asn 
    1430                 1435                 1440             


Lys Asn  Tyr Thr Tyr Met Ala  Gln Ala Val Asn Arg  Gly Leu Thr 
    1445                 1450                 1455             


Leu Val  Gly Leu Trp Asp Arg  Arg His Pro Gly Met  Ala Asp Tyr 
    1460                 1465                 1470             


Ile Pro  Val Ala Val Glu His  Ala Ile Glu Pro Asp  Thr Lys Leu 
    1475                 1480                 1485             


Thr Phe  Val Gly Asp Ile Ile  Cys Phe Ser Thr His  Leu Val Ser 
    1490                 1495                 1500             


Gln His  Gly Glu Pro Gly Ile  Trp Met Ile Ser Ala  Asn Asn Ile 
    1505                 1510                 1515             


Leu Gln  Thr Asp Ile Val Thr  Gly Val Gly Val Ala  Arg Ser Pro 
    1520                 1525                 1530             


Gly Thr  Ala Met Ile Phe His  Asp Ile Pro Gly Val  Val Lys Thr 
    1535                 1540                 1545             


Tyr Arg  Glu Val Val Val Asn  Ala Ser Ser Arg Leu  Met Leu Ser 
    1550                 1555                 1560             


Tyr Asp  Leu Lys Thr Tyr Leu  Thr Asn Thr Leu Asn  Ser Thr Val 
    1565                 1570                 1575             


Phe Lys  Leu Phe Ile Thr Thr  Gly Arg Asn Gly Val  Asn Leu Lys 
    1580                 1585                 1590             


Gly Phe  Cys Thr Pro Asn Gln  Ala Leu Ala Ile Thr  Lys Val Leu 
    1595                 1600                 1605             


Leu Pro  Ala Thr Leu Met Leu  Cys His Val Gln Phe  Ser Asn Thr 
    1610                 1615                 1620             


Leu Leu  Asp Ile Pro Ala Ser  Lys Val Phe Gln Val  His Ser Asp 
    1625                 1630                 1635             


Phe Ser  Met Glu Lys Asp His  Cys Glu Asp Ser Ala  Ile Leu Lys 
    1640                 1645                 1650             


Arg Phe  Thr Gly Ser Tyr Gln  Ile Leu Leu Leu Thr  Leu Phe Ala 
    1655                 1660                 1665             


Val Leu  Ala Ser Thr Ala Ser  Ile Phe Leu Ala Tyr  Asn Ala Phe 
    1670                 1675                 1680             


Leu Asn  Lys Ile Gln Thr Val  Pro Val Val Tyr Val  Pro Thr Leu 
    1685                 1690                 1695             


Gly Thr  Pro Gln Pro Gly Phe  Phe Asn Ser Thr Ser  Ser Pro Pro 
    1700                 1705                 1710             


His Phe  Met Ser Leu Gln Pro  Pro Leu Ala Gln Ser  Arg Leu Gln 
    1715                 1720                 1725             


His Trp  Leu Trp Ser Ile Arg  His 
    1730                 1735     


<210>  1944
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  1944

Met Asp His Lys Pro Leu Leu Gln Glu Arg Pro Pro Ala Tyr Asn Leu 
1               5                   10                  15      


Glu Ala Gly Gln Gly Asp Tyr Ala Cys Gly Pro His Gly Tyr Gly Ala 
            20                  25                  30          


Ile Pro Ala Ala Pro Pro Pro Pro Pro Tyr Pro Tyr Leu Val Thr Gly 
        35                  40                  45              


Ile Pro Thr His His Pro Arg Val Tyr Asn Ile His Ser Arg Thr Val 
    50                  55                  60                  


Thr Arg Tyr Pro Ala Asn Ser Ile Val Val Val Gly Gly Cys Pro Val 
65                  70                  75                  80  


Cys Arg His Gln Arg Ser Ser Trp Leu Tyr Thr Tyr Pro Leu Arg Val 
                85                  90                  95      


Cys Thr 
        


<210>  1945
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  1945

Met Cys Pro Gln Leu Ala Gly Ala Gly Ser Met Gly Ser Pro Gly Ala 
1               5                   10                  15      


Thr Thr Gly Trp Gly Leu Leu Asp Tyr Lys Thr Glu Lys Trp Ala Leu 
            20                  25                  30          


Leu Ala Lys Lys Gly Tyr Gln Glu Arg Asp Leu Glu Pro Gln Phe Ser 
        35                  40                  45              


Ile Ile Thr Lys Leu Lys Gly Val Ser Val Thr Gln Ile Lys Glu Leu 
    50                  55                  60                  


Gly Asn Arg Leu Trp Asp Val Ala Asp Phe Val Lys Pro Pro Gln Gly 
65                  70                  75                  80  


Glu Asn Val Phe Phe Leu Val Thr Asn Phe Leu Val Thr Pro Ala Gln 
                85                  90                  95      


Val Gln Gly Arg Cys Pro Glu His Pro Ser Val Pro Leu Ala Asn Cys 
            100                 105                 110         


Trp Val Asp Glu Asp Cys Pro Glu Gly Glu Gly Gly Thr His Ser His 
        115                 120                 125             


Gly Val Lys Thr Gly Gln Cys Val Val Phe Asn Gly Thr His Arg Thr 
    130                 135                 140                 


Cys Glu Ile Trp Ser Trp Cys Pro Val Glu Ser Gly Val Val Pro Ser 
145                 150                 155                 160 


Arg Pro Leu Leu Ala Gln Ala Gln Asn Phe Thr Leu Phe Ile Lys Asn 
                165                 170                 175     


Thr Val Thr Phe Ser Lys Phe Asn Phe Ser Lys Ser Asn Ala Leu Glu 
            180                 185                 190         


Thr Trp Asp Pro Thr Tyr Phe Lys His Cys Arg Tyr Glu Pro Gln Phe 
        195                 200                 205             


Ser Pro Tyr Cys Pro Val Phe Arg Ile Gly Asp Leu Val Ala Lys Ala 
    210                 215                 220                 


Gly Gly Thr Phe Glu Asp Leu Ala Leu Leu Gly Gly Ser Val Gly Ile 
225                 230                 235                 240 


Arg Val His Trp Asp Cys Asp Leu Asp Thr Gly Asp Ser Gly Cys Trp 
                245                 250                 255     


Pro His Tyr Ser Phe Gln Leu Gln Glu Lys Ser Tyr Asn Phe Arg Thr 
            260                 265                 270         


Ala Thr His Trp Trp Glu Gln Pro Gly Val Glu Ala Arg Thr Leu Leu 
        275                 280                 285             


Lys Leu Tyr Gly Ile Arg Phe Asp Ile Leu Val Thr Gly Gln Ala Gly 
    290                 295                 300                 


Lys Phe Gly Leu Ile Pro Thr Ala Val Thr Leu Gly Thr Gly Ala Ala 
305                 310                 315                 320 


Trp Leu Gly Val Val Thr Phe Phe Cys Asp Leu Leu Leu Leu Tyr Val 
                325                 330                 335     


Asp Arg Glu Ala His Phe Tyr Trp Arg Thr Lys Tyr Glu Glu Ala Lys 
            340                 345                 350         


Ala Pro Lys Ala Thr Ala Asn Ser Val Trp Arg Glu Leu Ala Leu Ala 
        355                 360                 365             


Ser Gln Ala Arg Leu Ala Glu Cys Leu Arg Arg Ser Ser Ala Pro Ala 
    370                 375                 380                 


Pro Thr Ala Thr Ala Ala Gly Ser Gln Thr Gln Thr Pro Gly Trp Pro 
385                 390                 395                 400 


Cys Pro Ser Ser Asp Thr His Leu Pro Thr His Ser Gly Ser Leu 
                405                 410                 415 


<210>  1946
<211>  692
<212>  PRT
<213>  Homo sapiens

<400>  1946

Met Ser Ser Ile Lys Gly Asn Lys Leu Glu Glu Gln Asp Pro Arg Pro 
1               5                   10                  15      


Leu Gln Pro Ile Pro Gly Leu Met Glu Gly Asn Lys Leu Glu Glu Gln 
            20                  25                  30          


Asp Ser Ser Pro Pro Gln Ser Thr Pro Gly Leu Met Lys Gly Asn Lys 
        35                  40                  45              


Arg Glu Glu Gln Gly Leu Gly Pro Glu Pro Ala Ala Pro Gln Gln Pro 
    50                  55                  60                  


Thr Ala Glu Glu Glu Ala Leu Ile Glu Phe His Arg Ser Tyr Arg Glu 
65                  70                  75                  80  


Leu Phe Glu Phe Phe Cys Asn Asn Thr Thr Ile His Gly Ala Ile Arg 
                85                  90                  95      


Leu Val Cys Ser Gln His Asn Arg Met Lys Thr Ala Phe Trp Ala Val 
            100                 105                 110         


Leu Trp Leu Cys Thr Phe Gly Met Met Tyr Trp Gln Phe Gly Leu Leu 
        115                 120                 125             


Phe Gly Glu Tyr Phe Ser Tyr Pro Val Ser Leu Asn Ile Asn Leu Asn 
    130                 135                 140                 


Ser Asp Lys Leu Val Phe Pro Ala Val Thr Ile Cys Thr Leu Asn Pro 
145                 150                 155                 160 


Tyr Arg Tyr Pro Glu Ile Lys Glu Glu Leu Glu Glu Leu Asp Arg Ile 
                165                 170                 175     


Thr Glu Gln Thr Leu Phe Asp Leu Tyr Lys Tyr Ser Ser Phe Thr Thr 
            180                 185                 190         


Leu Val Ala Gly Ser Arg Ser Arg Arg Asp Leu Arg Gly Thr Leu Pro 
        195                 200                 205             


His Pro Leu Gln Arg Leu Arg Val Pro Pro Pro Pro His Gly Ala Arg 
    210                 215                 220                 


Arg Ala Arg Ser Val Ala Ser Ser Leu Arg Asp Asn Asn Pro Gln Val 
225                 230                 235                 240 


Asp Trp Lys Asp Trp Lys Ile Gly Phe Gln Leu Cys Asn Gln Asn Lys 
                245                 250                 255     


Ser Asp Cys Phe Tyr Gln Thr Tyr Ser Ser Gly Val Asp Ala Val Arg 
            260                 265                 270         


Glu Trp Tyr Arg Phe His Tyr Ile Asn Ile Leu Ser Arg Leu Pro Glu 
        275                 280                 285             


Thr Leu Pro Ser Leu Glu Glu Asp Thr Leu Gly Asn Phe Ile Phe Ala 
    290                 295                 300                 


Cys Arg Phe Asn Gln Val Ser Cys Asn Gln Ala Asn Tyr Ser His Phe 
305                 310                 315                 320 


His His Pro Met Tyr Gly Asn Cys Tyr Thr Phe Asn Asp Lys Asn Asn 
                325                 330                 335     


Ser Asn Leu Trp Met Ser Ser Met Pro Gly Ile Asn Asn Gly Leu Ser 
            340                 345                 350         


Leu Met Leu Arg Ala Glu Gln Asn Asp Phe Ile Pro Leu Leu Ser Thr 
        355                 360                 365             


Val Thr Gly Ala Arg Val Met Val His Gly Gln Asp Glu Pro Ala Phe 
    370                 375                 380                 


Met Asp Asp Gly Gly Phe Asn Leu Arg Pro Gly Val Glu Thr Ser Ile 
385                 390                 395                 400 


Ser Met Arg Lys Glu Thr Leu Asp Arg Leu Gly Gly Asp Tyr Gly Asp 
                405                 410                 415     


Cys Thr Lys Asn Gly Ser Asp Val Pro Val Glu Asn Leu Tyr Pro Ser 
            420                 425                 430         


Lys Tyr Thr Gln Gln Val Cys Ile His Ser Cys Phe Gln Glu Ser Met 
        435                 440                 445             


Ile Lys Glu Cys Gly Cys Ala Tyr Ile Phe Tyr Pro Arg Pro Gln Asn 
    450                 455                 460                 


Val Glu Tyr Cys Asp Tyr Arg Lys His Ser Ser Trp Gly Tyr Cys Tyr 
465                 470                 475                 480 


Tyr Lys Leu Gln Val Asp Phe Ser Ser Asp His Leu Gly Cys Phe Thr 
                485                 490                 495     


Lys Cys Arg Lys Pro Cys Ser Val Thr Ser Tyr Gln Leu Ser Ala Gly 
            500                 505                 510         


Tyr Ser Arg Trp Pro Ser Val Thr Ser Gln Glu Trp Val Phe Gln Met 
        515                 520                 525             


Leu Ser Arg Gln Asn Asn Tyr Thr Val Asn Asn Lys Arg Asn Gly Val 
    530                 535                 540                 


Ala Lys Val Asn Ile Phe Phe Lys Glu Leu Asn Tyr Lys Thr Asn Ser 
545                 550                 555                 560 


Glu Ser Pro Ser Val Thr Met Val Thr Leu Leu Ser Asn Leu Gly Ser 
                565                 570                 575     


Gln Trp Ser Leu Trp Phe Gly Ser Ser Val Leu Ser Val Val Glu Met 
            580                 585                 590         


Ala Glu Leu Val Phe Asp Leu Leu Val Ile Met Phe Leu Met Leu Leu 
        595                 600                 605             


Arg Arg Phe Arg Ser Arg Tyr Trp Ser Pro Gly Arg Gly Gly Arg Gly 
    610                 615                 620                 


Ala Gln Glu Val Ala Ser Thr Leu Ala Ser Ser Pro Pro Ser His Phe 
625                 630                 635                 640 


Cys Pro His Pro Met Ser Leu Ser Leu Ser Gln Pro Gly Pro Ala Pro 
                645                 650                 655     


Ser Pro Ala Leu Thr Ala Pro Pro Pro Ala Tyr Ala Thr Leu Gly Pro 
            660                 665                 670         


Arg Pro Ser Pro Gly Gly Ser Ala Gly Ala Ser Ser Ser Thr Cys Pro 
        675                 680                 685             


Leu Gly Gly Pro 
    690         


<210>  1947
<211>  728
<212>  PRT
<213>  Homo sapiens

<400>  1947

Met Gly Met Ala Arg Gly Ser Leu Thr Arg Val Pro Gly Val Met Gly 
1               5                   10                  15      


Glu Gly Thr Gln Gly Pro Glu Leu Ser Leu Asp Pro Asp Pro Cys Ser 
            20                  25                  30          


Pro Gln Ser Thr Pro Gly Leu Met Lys Gly Asn Lys Leu Glu Glu Gln 
        35                  40                  45              


Asp Pro Arg Pro Leu Gln Pro Ile Pro Gly Leu Met Glu Gly Asn Lys 
    50                  55                  60                  


Leu Glu Glu Gln Asp Ser Ser Pro Pro Gln Ser Thr Pro Gly Leu Met 
65                  70                  75                  80  


Lys Gly Asn Lys Arg Glu Glu Gln Gly Leu Gly Pro Glu Pro Ala Ala 
                85                  90                  95      


Pro Gln Gln Pro Thr Ala Glu Glu Glu Ala Leu Ile Glu Phe His Arg 
            100                 105                 110         


Ser Tyr Arg Glu Leu Phe Glu Phe Phe Cys Asn Asn Thr Thr Ile His 
        115                 120                 125             


Gly Ala Ile Arg Leu Val Cys Ser Gln His Asn Arg Met Lys Thr Ala 
    130                 135                 140                 


Phe Trp Ala Val Leu Trp Leu Cys Thr Phe Gly Met Met Tyr Trp Gln 
145                 150                 155                 160 


Phe Gly Leu Leu Phe Gly Glu Tyr Phe Ser Tyr Pro Val Ser Leu Asn 
                165                 170                 175     


Ile Asn Leu Asn Ser Asp Lys Leu Val Phe Pro Ala Val Thr Ile Cys 
            180                 185                 190         


Thr Leu Asn Pro Tyr Arg Tyr Pro Glu Ile Lys Glu Glu Leu Glu Glu 
        195                 200                 205             


Leu Asp Arg Ile Thr Glu Gln Thr Leu Phe Asp Leu Tyr Lys Tyr Ser 
    210                 215                 220                 


Ser Phe Thr Thr Leu Val Ala Gly Ser Arg Ser Arg Arg Asp Leu Arg 
225                 230                 235                 240 


Gly Thr Leu Pro His Pro Leu Gln Arg Leu Arg Val Pro Pro Pro Pro 
                245                 250                 255     


His Gly Ala Arg Arg Ala Arg Ser Val Ala Ser Ser Leu Arg Asp Asn 
            260                 265                 270         


Asn Pro Gln Val Asp Trp Lys Asp Trp Lys Ile Gly Phe Gln Leu Cys 
        275                 280                 285             


Asn Gln Asn Lys Ser Asp Cys Phe Tyr Gln Thr Tyr Ser Ser Gly Val 
    290                 295                 300                 


Asp Ala Val Arg Glu Trp Tyr Arg Phe His Tyr Ile Asn Ile Leu Ser 
305                 310                 315                 320 


Arg Leu Pro Glu Thr Leu Pro Ser Leu Glu Glu Asp Thr Leu Gly Asn 
                325                 330                 335     


Phe Ile Phe Ala Cys Arg Phe Asn Gln Val Ser Cys Asn Gln Ala Asn 
            340                 345                 350         


Tyr Ser His Phe His His Pro Met Tyr Gly Asn Cys Tyr Thr Phe Asn 
        355                 360                 365             


Asp Lys Asn Asn Ser Asn Leu Trp Met Ser Ser Met Pro Gly Ile Asn 
    370                 375                 380                 


Asn Gly Leu Ser Leu Met Leu Arg Ala Glu Gln Asn Asp Phe Ile Pro 
385                 390                 395                 400 


Leu Leu Ser Thr Val Thr Gly Ala Arg Val Met Val His Gly Gln Asp 
                405                 410                 415     


Glu Pro Ala Phe Met Asp Asp Gly Gly Phe Asn Leu Arg Pro Gly Val 
            420                 425                 430         


Glu Thr Ser Ile Ser Met Arg Lys Glu Thr Leu Asp Arg Leu Gly Gly 
        435                 440                 445             


Asp Tyr Gly Asp Cys Thr Lys Asn Gly Ser Asp Val Pro Val Glu Asn 
    450                 455                 460                 


Leu Tyr Pro Ser Lys Tyr Thr Gln Gln Val Cys Ile His Ser Cys Phe 
465                 470                 475                 480 


Gln Glu Ser Met Ile Lys Glu Cys Gly Cys Ala Tyr Ile Phe Tyr Pro 
                485                 490                 495     


Arg Pro Gln Asn Val Glu Tyr Cys Asp Tyr Arg Lys His Ser Ser Trp 
            500                 505                 510         


Gly Tyr Cys Tyr Tyr Lys Leu Gln Val Asp Phe Ser Ser Asp His Leu 
        515                 520                 525             


Gly Cys Phe Thr Lys Cys Arg Lys Pro Cys Ser Val Thr Ser Tyr Gln 
    530                 535                 540                 


Leu Ser Ala Gly Tyr Ser Arg Trp Pro Ser Val Thr Ser Gln Glu Trp 
545                 550                 555                 560 


Val Phe Gln Met Leu Ser Arg Gln Asn Asn Tyr Thr Val Asn Asn Lys 
                565                 570                 575     


Arg Asn Gly Val Ala Lys Val Asn Ile Phe Phe Lys Glu Leu Asn Tyr 
            580                 585                 590         


Lys Thr Asn Ser Glu Ser Pro Ser Val Thr Met Val Thr Leu Leu Ser 
        595                 600                 605             


Asn Leu Gly Ser Gln Trp Ser Leu Trp Phe Gly Ser Ser Val Leu Ser 
    610                 615                 620                 


Val Val Glu Met Ala Glu Leu Val Phe Asp Leu Leu Val Ile Met Phe 
625                 630                 635                 640 


Leu Met Leu Leu Arg Arg Phe Arg Ser Arg Tyr Trp Ser Pro Gly Arg 
                645                 650                 655     


Gly Gly Arg Gly Ala Gln Glu Val Ala Ser Thr Leu Ala Ser Ser Pro 
            660                 665                 670         


Pro Ser His Phe Cys Pro His Pro Met Ser Leu Ser Leu Ser Gln Pro 
        675                 680                 685             


Gly Pro Ala Pro Ser Pro Ala Leu Thr Ala Pro Pro Pro Ala Tyr Ala 
    690                 695                 700                 


Thr Leu Gly Pro Arg Pro Ser Pro Gly Gly Ser Ala Gly Ala Ser Ser 
705                 710                 715                 720 


Ser Thr Cys Pro Leu Gly Gly Pro 
                725             


<210>  1948
<211>  567
<212>  PRT
<213>  Homo sapiens

<400>  1948

Met Leu Ser Ala Ile Tyr Thr Val Leu Ala Gly Leu Leu Phe Leu Pro 
1               5                   10                  15      


Leu Leu Val Asn Leu Cys Cys Pro Tyr Phe Phe Gln Asp Ile Gly Tyr 
            20                  25                  30          


Phe Leu Lys Val Ala Ala Val Gly Arg Arg Val Arg Ser Tyr Gly Lys 
        35                  40                  45              


Arg Arg Pro Ala Arg Thr Ile Leu Arg Ala Phe Leu Glu Lys Ala Arg 
    50                  55                  60                  


Gln Thr Pro His Lys Pro Phe Leu Leu Phe Arg Asp Glu Thr Leu Thr 
65                  70                  75                  80  


Tyr Ala Gln Val Asp Arg Arg Ser Asn Gln Val Ala Arg Ala Leu His 
                85                  90                  95      


Asp His Leu Gly Leu Arg Gln Gly Asp Cys Val Ala Leu Leu Met Gly 
            100                 105                 110         


Asn Glu Pro Ala Tyr Val Trp Leu Trp Leu Gly Leu Val Lys Leu Gly 
        115                 120                 125             


Cys Ala Met Ala Cys Leu Asn Tyr Asn Ile Arg Ala Lys Ser Leu Leu 
    130                 135                 140                 


His Cys Phe Gln Cys Cys Gly Ala Lys Val Leu Leu Val Ser Pro Glu 
145                 150                 155                 160 


Leu Gln Ala Ala Val Glu Glu Ile Leu Pro Ser Leu Lys Lys Asp Asp 
                165                 170                 175     


Val Ser Ile Tyr Tyr Val Ser Arg Thr Ser Asn Thr Asp Gly Ile Asp 
            180                 185                 190         


Ser Phe Leu Asp Lys Val Asp Glu Val Ser Thr Glu Pro Ile Pro Glu 
        195                 200                 205             


Ser Trp Arg Ser Glu Val Thr Phe Ser Thr Pro Ala Leu Tyr Ile Tyr 
    210                 215                 220                 


Thr Ser Gly Thr Thr Gly Ala Thr Leu Ala Leu Arg Thr Lys Phe Ser 
225                 230                 235                 240 


Ala Ser Gln Phe Trp Asp Asp Cys Arg Lys Tyr Asn Val Thr Val Ile 
                245                 250                 255     


Gln Tyr Ile Gly Glu Leu Leu Arg Tyr Leu Cys Asn Ser Pro Gln Lys 
            260                 265                 270         


Pro Asn Asp Arg Asp His Lys Val Arg Leu Ala Leu Gly Asn Gly Leu 
        275                 280                 285             


Arg Gly Asp Val Trp Arg Gln Phe Val Lys Arg Phe Gly Asp Ile Cys 
    290                 295                 300                 


Ile Tyr Glu Phe Tyr Ala Ala Thr Glu Gly Asn Ile Gly Phe Met Asn 
305                 310                 315                 320 


Tyr Ala Arg Lys Val Gly Ala Val Gly Arg Val Asn Tyr Leu Gln Lys 
                325                 330                 335     


Lys Ile Ile Thr Tyr Asp Leu Ile Lys Tyr Asp Val Glu Lys Asp Glu 
            340                 345                 350         


Pro Val Arg Asp Glu Asn Gly Tyr Cys Val Arg Val Pro Lys Gly Glu 
        355                 360                 365             


Val Gly Leu Leu Val Cys Lys Ile Thr Gln Leu Thr Pro Phe Asn Gly 
    370                 375                 380                 


Tyr Ala Gly Ala Lys Ala Gln Thr Glu Lys Lys Lys Leu Arg Asp Val 
385                 390                 395                 400 


Phe Lys Lys Gly Asp Leu Tyr Phe Asn Ser Gly Asp Leu Leu Met Val 
                405                 410                 415     


Asp His Glu Asn Phe Ile Tyr Phe His Asp Arg Val Gly Asp Thr Phe 
            420                 425                 430         


Arg Trp Lys Gly Glu Asn Val Ala Thr Thr Glu Val Ala Asp Thr Val 
        435                 440                 445             


Gly Leu Val Asp Phe Val Gln Glu Val Asn Val Tyr Gly Val His Val 
    450                 455                 460                 


Pro Asp His Glu Gly Arg Ile Gly Met Ala Ser Ile Lys Met Lys Glu 
465                 470                 475                 480 


Asn His Glu Phe Asp Gly Lys Lys Leu Phe Gln His Ile Ala Asp Tyr 
                485                 490                 495     


Leu Pro Ser Tyr Ala Arg Pro Arg Phe Leu Arg Ile Gln Asp Thr Ile 
            500                 505                 510         


Glu Ile Thr Gly Thr Phe Lys His Arg Lys Met Thr Leu Val Glu Glu 
        515                 520                 525             


Gly Phe Asn Pro Ala Val Ile Lys Asp Ala Leu Tyr Phe Leu Asp Asp 
    530                 535                 540                 


Thr Ala Lys Met Tyr Val Pro Met Thr Glu Asp Ile Tyr Asn Ala Ile 
545                 550                 555                 560 


Ser Ala Lys Thr Leu Lys Leu 
                565         


<210>  1949
<211>  823
<212>  PRT
<213>  Homo sapiens

<400>  1949

Met Asp Leu Asp Lys Pro Ser Val Trp Gly Ser Leu Lys Gln Arg Thr 
1               5                   10                  15      


Arg Pro Leu Leu Ile Asn Leu Ser Lys Lys Lys Val Lys Lys Asn Pro 
            20                  25                  30          


Ser Lys Pro Pro Asp Leu Arg Ala Arg His His Leu Asp Arg Arg Leu 
        35                  40                  45              


Ser Leu Ser Val Pro Asp Leu Leu Glu Ala Glu Ala Leu Ala Pro Glu 
    50                  55                  60                  


Gly Arg Pro Tyr Ser Gly Pro Gln Ser Ser Tyr Thr Ser Val Pro Ser 
65                  70                  75                  80  


Ser Leu Ser Thr Ala Gly Ile Phe Pro Lys Ser Ser Ser Ser Ser Leu 
                85                  90                  95      


Lys Gln Ser Glu Glu Glu Leu Asp Trp Ser Gln Glu Glu Ala Ser His 
            100                 105                 110         


Leu His Val Val Glu Thr Asp Ser Glu Glu Ala Tyr Ala Ser Pro Ala 
        115                 120                 125             


Glu Arg Arg Arg Val Ser Ser Asn Gly Ile Phe Asp Leu Gln Lys Thr 
    130                 135                 140                 


Ser Leu Gly Gly Asp Ala Pro Glu Glu Pro Glu Lys Leu Cys Gly Ser 
145                 150                 155                 160 


Ser Asp Leu Asn Ala Ser Met Thr Ser Gln His Phe Glu Glu Gln Ser 
                165                 170                 175     


Val Pro Gly Glu Ala Ser Asp Gly Leu Ser Asn Leu Pro Ser Pro Phe 
            180                 185                 190         


Ala Tyr Leu Leu Thr Ile His Leu Lys Glu Gly Arg Asn Leu Val Val 
        195                 200                 205             


Arg Asp Arg Cys Gly Thr Ser Asp Pro Tyr Val Lys Phe Lys Leu Asn 
    210                 215                 220                 


Gly Lys Thr Leu Tyr Lys Ser Lys Val Ile Tyr Lys Asn Leu Asn Pro 
225                 230                 235                 240 


Val Trp Asp Glu Ile Val Val Leu Pro Ile Gln Ser Leu Asp Gln Lys 
                245                 250                 255     


Leu Arg Val Lys Val Tyr Asp Arg Asp Leu Thr Thr Ser Asp Phe Met 
            260                 265                 270         


Gly Ser Ala Phe Val Ile Leu Ser Asp Leu Glu Leu Asn Arg Thr Thr 
        275                 280                 285             


Glu His Ile Leu Lys Leu Glu Asp Pro Asn Ser Leu Glu Asp Asp Met 
    290                 295                 300                 


Gly Val Ile Val Leu Asn Leu Asn Leu Val Val Lys Gln Gly Asp Phe 
305                 310                 315                 320 


Lys Arg His Arg Trp Ser Asn Arg Lys Arg Leu Ser Ala Ser Lys Ser 
                325                 330                 335     


Ser Leu Ile Arg Asn Leu Arg Leu Ser Glu Ser Leu Lys Lys Asn Gln 
            340                 345                 350         


Leu Trp Asn Gly Ile Ile Ser Ile Thr Leu Leu Glu Gly Lys Asn Val 
        355                 360                 365             


Ser Gly Gly Ser Met Thr Glu Met Phe Val Gln Leu Lys Leu Gly Asp 
    370                 375                 380                 


Gln Arg Tyr Lys Ser Lys Thr Leu Cys Lys Ser Ala Asn Pro Gln Trp 
385                 390                 395                 400 


Gln Glu Gln Phe Asp Phe His Tyr Phe Ser Asp Arg Met Gly Ile Leu 
                405                 410                 415     


Asp Ile Glu Val Trp Gly Lys Asp Asn Lys Lys His Glu Glu Arg Leu 
            420                 425                 430         


Gly Thr Cys Lys Val Asp Ile Ser Ala Leu Pro Leu Lys Gln Ala Asn 
        435                 440                 445             


Cys Leu Glu Leu Pro Leu Asp Ser Cys Leu Gly Ala Leu Leu Met Leu 
    450                 455                 460                 


Val Thr Leu Thr Pro Cys Ala Gly Val Ser Val Ser Asp Leu Cys Val 
465                 470                 475                 480 


Cys Pro Leu Ala Asp Leu Ser Glu Arg Lys Gln Ile Thr Gln Arg Tyr 
                485                 490                 495     


Cys Leu Gln Asn Ser Leu Lys Asp Val Lys Asp Val Gly Ile Leu Gln 
            500                 505                 510         


Val Lys Val Leu Lys Ala Ala Asp Leu Leu Ala Ala Asp Phe Ser Gly 
        515                 520                 525             


Lys Ser Asp Pro Phe Cys Leu Leu Glu Leu Gly Asn Asp Arg Leu Gln 
    530                 535                 540                 


Thr His Thr Val Tyr Lys Asn Leu Asn Pro Glu Trp Asn Lys Val Phe 
545                 550                 555                 560 


Thr Phe Pro Ile Lys Asp Ile His Asp Val Leu Glu Val Thr Val Phe 
                565                 570                 575     


Asp Glu Asp Gly Asp Lys Pro Pro Asp Phe Leu Gly Lys Val Ala Ile 
            580                 585                 590         


Pro Leu Leu Ser Ile Arg Asp Gly Gln Pro Asn Cys Tyr Val Leu Lys 
        595                 600                 605             


Asn Lys Asp Leu Glu Gln Ala Phe Lys Gly Val Ile Tyr Leu Glu Met 
    610                 615                 620                 


Asp Leu Ile Tyr Asn Pro Val Lys Ala Ser Ile Arg Thr Phe Thr Pro 
625                 630                 635                 640 


Arg Glu Lys Arg Phe Val Glu Asp Ser Arg Lys Leu Ser Lys Lys Ile 
                645                 650                 655     


Leu Ser Arg Asp Val Asp Arg Val Lys Arg Ile Thr Met Ala Ile Trp 
            660                 665                 670         


Asn Thr Met Gln Phe Leu Lys Ser Cys Phe Gln Trp Glu Ser Thr Leu 
        675                 680                 685             


Arg Ser Thr Ile Ala Phe Ala Glu Ser Glu Lys Lys Gly Leu Ile Glu 
    690                 695                 700                 


Arg Ile Tyr Met Val Gln Asp Ile Val Ser Thr Val Gln Asn Val Leu 
705                 710                 715                 720 


Glu Glu Ile Ala Ser Phe Gly Glu Arg Ile Lys Asn Thr Phe Asn Trp 
                725                 730                 735     


Thr Val Pro Phe Leu Ser Ser Leu Ala Cys Leu Ile Leu Ala Ala Ala 
            740                 745                 750         


Thr Ile Ile Leu Tyr Phe Ile Pro Leu Arg Tyr Ile Ile Leu Ile Trp 
        755                 760                 765             


Gly Ile Asn Lys Phe Thr Lys Lys Leu Arg Asn Pro Tyr Ser Ile Asp 
    770                 775                 780                 


Asn Asn Glu Leu Leu Asp Phe Leu Ser Arg Val Pro Ser Asp Val Gln 
785                 790                 795                 800 


Lys Val Gln Tyr Ala Glu Leu Lys Leu Cys Ser Ser His Ser Pro Leu 
                805                 810                 815     


Arg Lys Lys Arg Ser Ala Leu 
            820             


<210>  1950
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  1950

Met Gly Ile Leu Asp Ile Glu Val Trp Gly Lys Asp Asn Lys Lys His 
1               5                   10                  15      


Glu Glu Arg Leu Gly Thr Cys Lys Val Asp Ile Ser Ala Leu Pro Leu 
            20                  25                  30          


Lys Gln Ala Asn Cys Leu Glu Leu Pro Leu Asp Ser Cys Leu Gly Ala 
        35                  40                  45              


Leu Leu Met Leu Val Thr Leu Thr Pro Cys Ala Gly Val Ser Val Ser 
    50                  55                  60                  


Asp Leu Cys Val Cys Pro Leu Ala Asp Leu Ser Glu Arg Lys Gln Ile 
65                  70                  75                  80  


Thr Gln Arg Tyr Cys Leu Gln Asn Ser Leu Lys Asp Val Lys Asp Val 
                85                  90                  95      


Gly Ile Leu Gln Val Lys Val Leu Lys Ala Ala Asp Leu Leu Ala Ala 
            100                 105                 110         


Asp Phe Ser Gly Lys Ser Asp Pro Phe Cys Leu Leu Glu Leu Gly Asn 
        115                 120                 125             


Asp Arg Leu Gln Thr His Thr Val Tyr Lys Asn Leu Asn Pro Glu Trp 
    130                 135                 140                 


Asn Lys Val Phe Thr Phe Pro Ile Lys Asp Ile His Asp Val Leu Glu 
145                 150                 155                 160 


Val Thr Val Phe Asp Glu Asp Gly Asp Lys Pro Pro Asp Phe Leu Gly 
                165                 170                 175     


Lys Val Ala Ile Pro Leu Leu Ser Ile Arg Asp Gly Gln Pro Asn Cys 
            180                 185                 190         


Tyr Val Leu Lys Asn Lys Asp Leu Glu Gln Ala Phe Lys Gly Val Ile 
        195                 200                 205             


Tyr Leu Glu Met Asp Leu Ile Tyr Asn Pro Val Lys Ala Ser Ile Arg 
    210                 215                 220                 


Thr Phe Thr Pro Arg Glu Lys Arg Phe Val Glu Asp Ser Arg Lys Leu 
225                 230                 235                 240 


Ser Lys Lys Ile Leu Ser Arg Asp Val Asp Arg Val Lys Arg Ile Thr 
                245                 250                 255     


Met Ala Ile Trp Asn Thr Met Gln Phe Leu Lys Ser Cys Phe Gln Trp 
            260                 265                 270         


Glu Ser Thr Leu Arg Ser Thr Ile Ala Phe Ala His Arg Lys Glu Glu 
        275                 280                 285             


Pro Pro Leu Ser Met Lys Cys Thr Leu Phe Ser Gly Asp Ile Gly Pro 
    290                 295                 300                 


Ser Leu 
305     


<210>  1951
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  1951

Met Glu Leu Leu Gln Val Thr Ile Leu Phe Leu Leu Pro Ser Ile Cys 
1               5                   10                  15      


Ser Ser Asn Ser Thr Gly Val Leu Glu Ala Ala Asn Asn Ser Leu Val 
            20                  25                  30          


Val Thr Thr Thr Lys Pro Ser Ile Thr Thr Pro Asn Thr Glu Ser Leu 
        35                  40                  45              


Gln Lys Asn Val Val Thr Pro Thr Thr Gly Thr Thr Pro Lys Gly Thr 
    50                  55                  60                  


Ile Thr Asn Glu Leu Leu Lys Met Ser Leu Met Ser Thr Ala Thr Phe 
65                  70                  75                  80  


Leu Thr Ser Lys Asp Glu Gly Leu Lys Ala Thr Thr Thr Asp Val Arg 
                85                  90                  95      


Lys Asn Asp Ser Ile Ile Ser Asn Val Thr Val Thr Ser Val Thr Leu 
            100                 105                 110         


Pro Asn Ala Val Ser Thr Leu Gln Ser Ser Lys Pro Lys Ser Ser Val 
        115                 120                 125             


Leu Gln Pro Asp Ala Ser Pro Ser Lys Thr Gly Thr Leu Thr Ser Ile 
    130                 135                 140                 


Pro Val Thr Ile Pro Glu Asn Thr Ser Gln Ser Gln Val Ile Gly Thr 
145                 150                 155                 160 


Glu Gly Gly Lys Asn Ala Ser Thr Ser Ala Thr Ser Arg Ser Tyr Ser 
                165                 170                 175     


Ser Ile Ile Leu Pro Val Val Ile Ala Leu Ile Val Ile Thr Leu Ser 
            180                 185                 190         


Val Phe Val Leu Val Gly Leu Tyr Arg Met Cys Trp Lys Ala Asp Pro 
        195                 200                 205             


Gly Thr Pro Glu Asn Gly Asn Asp Gln Pro Gln Ser Asp Lys Glu Ser 
    210                 215                 220                 


Val Lys Leu Leu Thr Val Lys Thr Ile Ser His Glu Ser Gly Glu His 
225                 230                 235                 240 


Ser Ala Gln Gly Lys Thr Lys Asn 
                245             


<210>  1952
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  1952

Met Ala Leu Met Leu Ser Leu Val Leu Ser Leu Leu Lys Leu Gly Ser 
1               5                   10                  15      


Ala Leu Gly Ser Val Pro Leu Ile Ser Ile Thr Gly Tyr Val Asp Arg 
            20                  25                  30          


Asp Ile Gln Leu Leu Cys Gln Ser Ser Gly Trp Phe Pro Arg Pro Thr 
        35                  40                  45              


Ala Lys Trp Lys Gly Pro Gln Gly Gln Asp Leu Ser Thr Asp Ser Arg 
    50                  55                  60                  


Thr Asn Arg Asp Met His Gly Leu Phe Asp Val Glu Ile Ser Leu Thr 
65                  70                  75                  80  


Val Gln Glu Asn Ala Gly Ser Ile Ser Cys Ser Met Arg His Ala His 
                85                  90                  95      


Leu Ser Arg Glu Val Glu Ser Arg Val Gln Ile Gly Asp Thr Phe Phe 
            100                 105                 110         


Glu Pro Ile Ser Trp His Leu Ala Thr Lys Val Leu Gly Ile Leu Cys 
        115                 120                 125             


Cys Gly Leu Phe Phe Gly Ile Val Gly Leu Lys Ile Phe Phe Ser Lys 
    130                 135                 140                 


Phe Gln Trp Lys Ile Gln Ala Glu Leu Asp Trp Arg Arg Lys His Gly 
145                 150                 155                 160 


Gln Ala Glu Leu Arg Asp Ala Arg Lys His Ala Val Glu Val Thr Leu 
                165                 170                 175     


Asp Pro Glu Thr Ala His Pro Lys Leu Cys Val Ser Asp Leu Lys Thr 
            180                 185                 190         


Val Thr His Arg Lys Ala Pro Gln Glu Val Pro His Ser Glu Lys Arg 
        195                 200                 205             


Phe Thr Arg Lys Ser Val Val Ala Ser Gln Ser Phe Gln Ala Gly Lys 
    210                 215                 220                 


His Tyr Trp Glu Val Asp Gly Gly His Asn Lys Arg Trp Arg Val Gly 
225                 230                 235                 240 


Val Cys Arg Asp Asp Val Asp Arg Arg Lys Glu Tyr Val Thr Leu Ser 
                245                 250                 255     


Pro Asp His Gly Tyr Trp Val Leu Arg Leu Asn Gly Glu His Leu Tyr 
            260                 265                 270         


Phe Thr Leu Asn Pro Arg Phe Ile Ser Val Phe Pro Arg Thr Pro Pro 
        275                 280                 285             


Thr Lys Ile Gly Val Phe Leu Asp Tyr Glu Cys Gly Thr Ile Ser Phe 
    290                 295                 300                 


Phe Asn Ile Asn Asp Gln Ser Leu Ile Tyr Thr Leu Thr Cys Arg Phe 
305                 310                 315                 320 


Glu Gly Leu Leu Arg Pro Tyr Ile Glu Tyr Pro Ser Tyr Asn Glu Gln 
                325                 330                 335     


Asn Gly Thr Pro Ile Val Ile Cys Pro Val Thr Gln Glu Ser Glu Lys 
            340                 345                 350         


Glu Ala Ser Trp Gln Arg Ala Ser Ala Ile Pro Glu Thr Ser Asn Ser 
        355                 360                 365             


Glu Ser Ser Ser Gln Ala Thr Thr Pro Phe Leu Pro Arg Gly Glu Met 
    370                 375                 380                 


<210>  1953
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  1953

Met Ala Leu Met Leu Ser Leu Val Leu Ser Leu Leu Lys Leu Gly Ser 
1               5                   10                  15      


Gly Gln Trp Gln Val Phe Gly Pro Asp Lys Pro Val Gln Ala Leu Val 
            20                  25                  30          


Gly Glu Asp Ala Ala Phe Ser Cys Phe Leu Ser Pro Lys Thr Asn Ala 
        35                  40                  45              


Glu Ala Met Glu Val Arg Phe Phe Arg Gly Gln Phe Ser Ser Val Val 
    50                  55                  60                  


His Leu Tyr Arg Asp Gly Lys Asp Gln Pro Phe Met Gln Met Pro Gln 
65                  70                  75                  80  


Tyr Gln Gly Arg Thr Lys Leu Val Lys Asp Ser Ile Ala Glu Gly Arg 
                85                  90                  95      


Ile Ser Leu Arg Leu Glu Asn Ile Thr Val Leu Asp Ala Gly Leu Tyr 
            100                 105                 110         


Gly Cys Arg Ile Ser Ser Gln Ser Tyr Tyr Gln Lys Ala Ile Trp Glu 
        115                 120                 125             


Leu Gln Val Ser Ala Leu Gly Ser Val Pro Leu Ile Ser Ile Thr Gly 
    130                 135                 140                 


Tyr Val Asp Arg Asp Ile Gln Leu Leu Cys Gln Ser Ser Gly Trp Phe 
145                 150                 155                 160 


Pro Arg Pro Thr Ala Lys Trp Lys Gly Pro Gln Gly Gln Asp Leu Ser 
                165                 170                 175     


Thr Asp Ser Arg Thr Asn Arg Asp Met His Gly Leu Phe Asp Val Glu 
            180                 185                 190         


Ile Ser Leu Thr Val Gln Glu Asn Ala Gly Ser Ile Ser Cys Ser Met 
        195                 200                 205             


Arg His Ala His Leu Ser Arg Glu Val Glu Ser Arg Val Gln Ile Gly 
    210                 215                 220                 


Asp Thr Phe Phe Glu Pro Ile Ser Trp His Leu Ala Thr Lys Val Leu 
225                 230                 235                 240 


Gly Ile Leu Cys Cys Gly Leu Phe Phe Gly Ile Val Gly Leu Lys Ile 
                245                 250                 255     


Phe Phe Ser Lys Phe Gln Cys Lys Arg Glu Arg Glu Ala Trp Ala Gly 
            260                 265                 270         


Ala Leu Phe Met Val Pro Ala Gly Thr Gly Ser Glu Met Leu Pro His 
        275                 280                 285             


Pro Ala Ala Ser Leu Leu Leu Val Leu Ala Ser Arg Gly Pro Gly Pro 
    290                 295                 300                 


Lys Lys Leu Glu Lys Lys Ala Arg Thr Gly Arg Ile Glu Arg Arg Pro 
305                 310                 315                 320 


Glu Thr Arg Ser Gly Gly Asp Ser Gly Ser Arg Asp Gly Ser Pro Glu 
                325                 330                 335     


Ala Leu Arg Phe 
            340 


<210>  1954
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  1954

Met Trp Thr Trp Phe Val Lys Ser Leu Gly Ser Val Pro Leu Ile Ser 
1               5                   10                  15      


Ile Thr Gly Tyr Val Asp Arg Asp Ile Gln Leu Leu Cys Gln Ser Ser 
            20                  25                  30          


Gly Trp Phe Pro Arg Pro Thr Ala Lys Trp Lys Gly Pro Gln Gly Gln 
        35                  40                  45              


Asp Leu Ser Thr Asp Ser Arg Thr Asn Arg Asp Met His Gly Leu Phe 
    50                  55                  60                  


Asp Val Glu Ile Ser Leu Thr Val Gln Glu Asn Ala Gly Ser Ile Ser 
65                  70                  75                  80  


Cys Ser Met Arg His Ala His Leu Ser Arg Glu Val Glu Ser Arg Val 
                85                  90                  95      


Gln Ile Gly Asp Thr Phe Phe Glu Pro Ile Ser Trp His Leu Ala Thr 
            100                 105                 110         


Lys Val Leu Gly Ile Leu Cys Cys Gly Leu Phe Phe Gly Ile Val Gly 
        115                 120                 125             


Leu Lys Ile Phe Phe Ser Lys Phe Gln Trp Lys Ile Gln Ala Glu Leu 
    130                 135                 140                 


Asp Trp Arg Arg Lys His Gly Gln Ala Glu Leu Arg Asp Ala Arg Lys 
145                 150                 155                 160 


His Ala Val Glu Val Thr Leu Asp Pro Glu Thr Ala His Pro Lys Leu 
                165                 170                 175     


Cys Val Ser Asp Leu Lys Thr Val Thr His Arg Lys Ala Pro Gln Glu 
            180                 185                 190         


Val Pro His Ser Glu Lys Arg Phe Thr Arg Lys Ser Val Val Ala Ser 
        195                 200                 205             


Gln Ser Phe Gln Ala Gly Lys His Tyr Trp Glu Val Asp Gly Gly His 
    210                 215                 220                 


Asn Lys Arg Trp Arg Val Gly Val Cys Arg Asp Asp Val Asp Arg Arg 
225                 230                 235                 240 


Lys Glu Tyr Val Thr Leu Ser Pro Asp His Gly Tyr Trp Val Leu Arg 
                245                 250                 255     


Leu Asn Gly Glu His Leu Tyr Phe Thr Leu Asn Pro Arg Phe Ile Ser 
            260                 265                 270         


Val Phe Pro Arg Thr Pro Pro Thr Lys Ile Gly Val Phe Leu Asp Tyr 
        275                 280                 285             


Glu Cys Gly Thr Ile Ser Phe Phe Asn Ile Asn Asp Gln Ser Leu Ile 
    290                 295                 300                 


Tyr Thr Leu Thr Cys Arg Phe Glu Gly Leu Leu Arg Pro Tyr Ile Glu 
305                 310                 315                 320 


Tyr Pro Ser Tyr Asn Glu Gln Asn Gly Thr Pro Ile Val Ile Cys Pro 
                325                 330                 335     


Val Thr Gln Glu Ser Glu Lys Glu Ala Ser Trp Gln Arg Ala Ser Ala 
            340                 345                 350         


Ile Pro Glu Thr Ser Asn Ser Glu Ser Ser Ser Gln Ala Thr Thr Pro 
        355                 360                 365             


Phe Leu Pro Arg Gly Glu Met 
    370                 375 


<210>  1955
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  1955

Met His Gly Leu Phe Asp Val Glu Ile Ser Leu Thr Val Gln Glu Asn 
1               5                   10                  15      


Ala Gly Ser Ile Ser Cys Ser Met Arg His Ala His Leu Ser Arg Glu 
            20                  25                  30          


Val Glu Ser Arg Val Gln Ile Gly Asp Thr Phe Phe Glu Pro Ile Ser 
        35                  40                  45              


Trp His Leu Ala Thr Lys Val Leu Gly Ile Leu Cys Cys Gly Leu Phe 
    50                  55                  60                  


Phe Gly Ile Val Gly Leu Lys Ile Phe Phe Ser Lys Phe Gln Trp Lys 
65                  70                  75                  80  


Ile Gln Ala Glu Leu Asp Trp Arg Arg Lys His Gly Gln Ala Glu Leu 
                85                  90                  95      


Arg Asp Ala Arg Lys His Ala Val Glu Val Thr Leu Asp Pro Glu Thr 
            100                 105                 110         


Ala His Pro Lys Leu Cys Val Ser Asp Leu Lys Thr Val Thr His Arg 
        115                 120                 125             


Lys Ala Pro Gln Glu Val Pro His Ser Glu Lys Arg Phe Thr Arg Lys 
    130                 135                 140                 


Ser Val Val Ala Ser Gln Ser Phe Gln Ala Gly Lys His Tyr Trp Glu 
145                 150                 155                 160 


Val Asp Gly Gly His Asn Lys Arg Trp Arg Val Gly Val Cys Arg Asp 
                165                 170                 175     


Asp Val Asp Arg Arg Lys Glu Tyr Val Thr Leu Ser Pro Asp His Gly 
            180                 185                 190         


Tyr Trp Val Leu Arg Leu Asn Gly Glu His Leu Tyr Phe Thr Leu Asn 
        195                 200                 205             


Pro Arg Phe Ile Ser Val Phe Pro Arg Thr Pro Pro Thr Lys Ile Gly 
    210                 215                 220                 


Val Phe Leu Asp Tyr Glu Cys Gly Thr Ile Ser Phe Phe Asn Ile Asn 
225                 230                 235                 240 


Asp Gln Ser Leu Ile Tyr Thr Leu Thr Cys Arg Phe Glu Gly Leu Leu 
                245                 250                 255     


Arg Pro Tyr Ile Glu Tyr Pro Ser Tyr Asn Glu Gln Asn Gly Thr Pro 
            260                 265                 270         


Ile Val Ile Cys Pro Val Thr Gln Glu Ser Glu Lys Glu Ala Ser Trp 
        275                 280                 285             


Gln Arg Ala Ser Ala Ile Pro Glu Thr Ser Asn Ser Glu Ser Ser Ser 
    290                 295                 300                 


Gln Ala Thr Thr Pro Phe Leu Pro Arg Gly Glu Met 
305                 310                 315     


<210>  1956
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  1956

Met Arg Leu Gln Gly Ala Ile Phe Val Leu Leu Pro His Leu Gly Pro 
1               5                   10                  15      


Ile Leu Val Trp Leu Phe Thr Arg Asp His Met Ser Gly Trp Cys Glu 
            20                  25                  30          


Gly Pro Arg Met Leu Ser Trp Cys Pro Phe Tyr Lys Val Leu Leu Leu 
        35                  40                  45              


Val Gln Thr Ala Ile Tyr Ser Val Val Gly Tyr Ala Ser Tyr Leu Val 
    50                  55                  60                  


Trp Lys Asp Leu Gly Gly Gly Leu Gly Trp Pro Leu Ala Leu Pro Leu 
65                  70                  75                  80  


Gly Leu Tyr Ala Val Gln Leu Thr Ile Ser Trp Thr Val Leu Val Leu 
                85                  90                  95      


Phe Phe Thr Val His Asn Pro Gly Leu Ala Leu Leu His Leu Leu Leu 
            100                 105                 110         


Leu Tyr Gly Leu Val Val Ser Thr Ala Leu Ile Trp His Pro Ile Asn 
        115                 120                 125             


Lys Leu Ala Ala Leu Leu Leu Leu Pro Tyr Leu Ala Trp Leu Thr Val 
    130                 135                 140                 


Thr Ser Ala Leu Thr Tyr His Leu Trp Arg Asp Ser Leu Cys Pro Val 
145                 150                 155                 160 


His Gln Pro Gln Pro Thr Glu Lys Ser Asp 
                165                 170 


<210>  1957
<211>  557
<212>  PRT
<213>  Homo sapiens

<400>  1957

Met Val Gly Gln Met Tyr Cys Tyr Pro Gly Ser His Leu Ala Arg Ala 
1               5                   10                  15      


Leu Thr Arg Ala Leu Ala Leu Ala Leu Val Leu Ala Leu Leu Val Gly 
            20                  25                  30          


Pro Phe Leu Ser Gly Leu Ala Gly Ala Ile Pro Ala Pro Gly Gly Arg 
        35                  40                  45              


Trp Ala Arg Asp Gly Gln Val Pro Pro Ala Ser Arg Ser Arg Ser Val 
    50                  55                  60                  


Leu Leu Asp Val Ser Ala Gly Gln Leu Leu Met Val Asp Gly Arg His 
65                  70                  75                  80  


Pro Asp Ala Val Ala Trp Ala Asn Leu Thr Asn Ala Ile Arg Glu Thr 
                85                  90                  95      


Gly Trp Ala Phe Leu Glu Leu Gly Thr Ser Gly Gln Tyr Asn Asp Ser 
            100                 105                 110         


Leu Gln Ala Tyr Ala Ala Gly Val Val Glu Ala Ala Val Ser Glu Glu 
        115                 120                 125             


Leu Ile Tyr Met His Trp Met Asn Thr Val Val Asn Tyr Cys Gly Pro 
    130                 135                 140                 


Phe Glu Tyr Glu Val Gly Tyr Cys Glu Arg Leu Lys Ser Phe Leu Glu 
145                 150                 155                 160 


Ala Asn Leu Glu Trp Met Gln Glu Glu Met Glu Ser Asn Pro Asp Ser 
                165                 170                 175     


Pro Tyr Trp His Gln Val Arg Leu Thr Leu Leu Gln Leu Lys Gly Leu 
            180                 185                 190         


Glu Asp Ser Tyr Glu Gly Arg Val Ser Phe Pro Ala Gly Lys Phe Thr 
        195                 200                 205             


Ile Lys Pro Leu Gly Phe Leu Leu Leu Gln Leu Ser Gly Asp Leu Glu 
    210                 215                 220                 


Asp Leu Glu Leu Ala Leu Asn Lys Thr Lys Ile Lys Pro Ser Leu Gly 
225                 230                 235                 240 


Ser Gly Ser Cys Ser Ala Leu Ile Lys Leu Leu Pro Gly Gln Ser Asp 
                245                 250                 255     


Leu Leu Val Ala His Asn Thr Trp Asn Asn Tyr Gln His Met Leu Arg 
            260                 265                 270         


Val Ile Lys Lys Tyr Trp Leu Gln Phe Arg Glu Gly Pro Trp Gly Asp 
        275                 280                 285             


Tyr Pro Leu Val Pro Gly Asn Lys Leu Val Phe Ser Ser Tyr Pro Gly 
    290                 295                 300                 


Thr Ile Phe Ser Cys Asp Asp Phe Tyr Ile Leu Gly Ser Gly Leu Val 
305                 310                 315                 320 


Thr Leu Glu Thr Thr Ile Gly Asn Lys Asn Pro Ala Leu Trp Lys Tyr 
                325                 330                 335     


Val Arg Pro Arg Gly Cys Val Leu Glu Trp Val Arg Asn Ile Val Ala 
            340                 345                 350         


Asn Arg Leu Ala Ser Asp Gly Ala Thr Trp Ala Asp Ile Phe Lys Arg 
        355                 360                 365             


Phe Asn Ser Gly Thr Gly Met Val Val Val Ala Asp Lys Thr Ser Glu 
    370                 375                 380                 


Leu Tyr Gln Lys Thr Tyr Trp Ala Ser Tyr Asn Ile Pro Ser Phe Glu 
385                 390                 395                 400 


Thr Val Phe Asn Ala Ser Gly Leu Gln Ala Leu Val Ala Gln Tyr Gly 
                405                 410                 415     


Asp Trp Phe Ser Tyr Asp Gly Ser Pro Arg Ala Gln Ile Phe Arg Arg 
            420                 425                 430         


Asn Gln Ser Leu Val Gln Asp Met Asp Ser Met Val Arg Leu Met Arg 
        435                 440                 445             


Tyr Asn Asp Phe Leu His Asp Pro Leu Ser Leu Cys Lys Ala Cys Asn 
    450                 455                 460                 


Pro Gln Pro Asn Gly Glu Asn Ala Ile Ser Ala Arg Ser Asp Leu Asn 
465                 470                 475                 480 


Pro Ala Asn Gly Ser Tyr Pro Phe Gln Ala Leu Arg Gln Arg Ser His 
                485                 490                 495     


Gly Gly Ile Asp Val Lys Val Thr Ser Met Ser Leu Ala Arg Ile Leu 
            500                 505                 510         


Ser Leu Leu Ala Ala Ser Gly Pro Thr Trp Asp Gln Val Pro Pro Phe 
        515                 520                 525             


Gln Trp Ser Thr Ser Pro Phe Ser Gly Leu Leu His Met Gly Gln Pro 
    530                 535                 540                 


Asp Leu Trp Lys Phe Ala Pro Val Lys Val Ser Trp Asp 
545                 550                 555         


<210>  1958
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  1958

Met Thr Pro Pro Glu Arg Leu Phe Leu Pro Arg Val Cys Gly Thr Thr 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Gly Leu Leu Leu Val Leu Leu Pro Gly Ala 
            20                  25                  30          


Gln Gly Leu Pro Gly Val Gly Leu Thr Pro Ser Ala Ala Gln Thr Ala 
        35                  40                  45              


Arg Gln His Pro Lys Met His Leu Ala His Ser Thr Leu Lys Pro Ala 
    50                  55                  60                  


Ala His Leu Ile Gly Asp Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg 
65                  70                  75                  80  


Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp Gly Phe Ser Leu Ser Asn 
                85                  90                  95      


Asn Ser Leu Leu Val Pro Thr Ser Gly Ile Tyr Phe Val Tyr Ser Gln 
            100                 105                 110         


Val Val Phe Ser Gly Lys Ala Tyr Ser Pro Lys Ala Thr Ser Ser Pro 
        115                 120                 125             


Leu Tyr Leu Ala His Glu Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe 
    130                 135                 140                 


His Val Pro Leu Leu Ser Ser Gln Lys Met Val Tyr Pro Gly Leu Gln 
145                 150                 155                 160 


Glu Pro Trp Leu His Ser Met Tyr His Gly Ala Ala Phe Gln Leu Thr 
                165                 170                 175     


Gln Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Pro His Leu Val 
            180                 185                 190         


Leu Ser Pro Ser Thr Val Phe Phe Gly Ala Phe Ala Leu 
        195                 200                 205 


<210>  1959
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  1959

Met Leu Gln Gly His Ser Ser Val Phe Gln Ala Leu Leu Gly Thr Phe 
1               5                   10                  15      


Phe Thr Trp Gly Met Thr Ala Ala Gly Ala Ala Leu Val Phe Val Phe 
            20                  25                  30          


Ser Ser Gly Gln Arg Arg Ile Leu Asp Gly Ser Leu Gly Phe Ala Ala 
        35                  40                  45              


Gly Val Met Leu Ala Ala Ser Tyr Trp Ser Leu Leu Ala Pro Ala Val 
    50                  55                  60                  


Glu Met Ala Thr Ser Ser Gly Gly Phe Gly Ala Phe Ala Phe Phe Pro 
65                  70                  75                  80  


Val Ala Val Gly Phe Thr Leu Gly Ala Ala Phe Val Tyr Leu Ala Asp 
                85                  90                  95      


Leu Leu Met Pro His Leu Gly Ala Ala Glu Asp Pro Gln Thr Thr Leu 
            100                 105                 110         


Ala Leu Asn Phe Gly Ser Thr Leu Met Lys Lys Lys Ser Asp Pro Glu 
        115                 120                 125             


Gly Pro Ala Leu Leu Phe Pro Glu Ser Glu Leu Ser Ile Arg Ile Gly 
    130                 135                 140                 


Arg Ala Gly Leu Leu Ser Asp Lys Ser Glu Asn Gly Glu Ala Tyr Gln 
145                 150                 155                 160 


Arg Lys Lys Ala Ala Ala Thr Gly Leu Pro Glu Gly Pro Ala Val Pro 
                165                 170                 175     


Val Pro Ser Arg Gly Asn Leu Ala Gln Pro Gly Gly Ser Ser Trp Arg 
            180                 185                 190         


Arg Ile Ala Leu Leu Ile Leu Ala Ile Thr Ile His Asn Val Pro Glu 
        195                 200                 205             


Gly Leu Ala Val Gly Val Gly Phe Gly Ala Ile Glu Lys Thr Ala Ser 
    210                 215                 220                 


Ala Thr Phe Glu Ser Ala Arg Asn Leu Ala Ile Gly Ile Gly Ile Gln 
225                 230                 235                 240 


Asn Phe Pro Glu Gly Leu Ala Val Ser Leu Pro Leu Arg Gly Ala Gly 
                245                 250                 255     


Phe Ser Thr Trp Arg Ala Phe Trp Tyr Gly Gln Leu Ser Gly Met Val 
            260                 265                 270         


Glu Pro Leu Ala Gly Val Phe Gly Ala Phe Ala Val Val Leu Ala Glu 
        275                 280                 285             


Pro Ile Leu Pro Tyr Ala Leu Ala Phe Ala Ala Gly Ala Met Val Tyr 
    290                 295                 300                 


Val Val Met Asp Asp Ile Ile Pro Glu Ala Gln Ile Ser Gly Asn Gly 
305                 310                 315                 320 


Lys Leu Ala Ser Trp Ala Ser Ile Leu Gly Phe Val Val Met Met Ser 
                325                 330                 335     


Leu Asp Val Gly Leu Gly 
            340         


<210>  1960
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  1960

Met Pro Val Gln Leu Ser Glu His Pro Glu Trp Asn Glu Ser Met His 
1               5                   10                  15      


Ser Leu Arg Ile Ser Val Gly Gly Leu Pro Val Leu Ala Ser Met Thr 
            20                  25                  30          


Lys Ala Ala Asp Pro Arg Phe Arg Pro Arg Trp Lys Val Ile Leu Thr 
        35                  40                  45              


Phe Phe Val Gly Ala Ala Ile Leu Trp Leu Leu Cys Ser His Arg Pro 
    50                  55                  60                  


Ala Pro Gly Arg Pro Pro Thr His Asn Ala His Asn Trp Arg Leu Gly 
65                  70                  75                  80  


Gln Ala Pro Ala Asn Trp Tyr Asn Asp Thr Tyr Pro Leu Ser Pro Pro 
                85                  90                  95      


Gln Arg Thr Pro Ala Gly Ile Arg Tyr Arg Ile Ala Val Ile Ala Asp 
            100                 105                 110         


Leu Asp Thr Glu Ser Arg Ala Gln Glu Glu Asn Thr Trp Phe Ser Tyr 
        115                 120                 125             


Leu Lys Lys Gly Tyr Leu Thr Leu Ser Asp Ser Gly Asp Lys Val Ala 
    130                 135                 140                 


Val Glu Trp Asp Lys Asp His Gly Val Leu Glu Ser His Leu Ala Glu 
145                 150                 155                 160 


Lys Gly Arg Gly Met Glu Leu Ser Asp Leu Ile Val Phe Asn Gly Lys 
                165                 170                 175     


Leu Tyr Ser Val Asp Asp Arg Thr Gly Val Val Tyr Gln Ile Glu Gly 
            180                 185                 190         


Ser Lys Ala Val Pro Trp Val Ile Leu Ser Asp Gly Asp Gly Thr Val 
        195                 200                 205             


Glu Lys Gly Phe Lys Ala Glu Trp Leu Ala Val Lys Asp Glu Arg Leu 
    210                 215                 220                 


Tyr Val Gly Gly Leu Gly Lys Glu Trp Thr Thr Thr Thr Gly Asp Val 
225                 230                 235                 240 


Val Asn Glu Asn Pro Glu Trp Val Lys Val Val Gly Tyr Lys Gly Ser 
                245                 250                 255     


Val Asp His Glu Asn Trp Val Ser Asn Tyr Asn Ala Leu Arg Ala Ala 
            260                 265                 270         


Ala Gly Ile Gln Pro Pro Gly Tyr Leu Ile His Glu Ser Ala Cys Trp 
        275                 280                 285             


Ser Asp Thr Leu Gln Arg Trp Phe Phe Leu Pro Arg Arg Ala Ser Gln 
    290                 295                 300                 


Glu Arg Tyr Ser Glu Lys Asp Asp Glu Arg Lys Gly Ala Asn Leu Leu 
305                 310                 315                 320 


Leu Ser Ala Ser Pro Asp Phe Gly Asp Ile Ala Val Ser His Val Gly 
                325                 330                 335     


Ala Val Val Pro Thr His Gly Phe Ser Ser Phe Lys Phe Ile Pro Asn 
            340                 345                 350         


Thr Asp Asp Gln Ile Ile Val Ala Leu Lys Ser Glu Glu Asp Ser Gly 
        355                 360                 365             


Arg Val Ala Ser Tyr Ile Met Ala Phe Thr Leu Asp Gly Arg Phe Leu 
    370                 375                 380                 


Leu Pro Glu Thr Lys Ile Gly Ser Val Lys Tyr Glu Gly Ile Glu Phe 
385                 390                 395                 400 


Ile 
    


<210>  1961
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  1961

Met Pro Val Gln Leu Ser Glu His Pro Glu Trp Asn Glu Ser Met His 
1               5                   10                  15      


Ser Leu Arg Ile Ser Val Gly Gly Leu Pro Val Leu Ala Ser Met Thr 
            20                  25                  30          


Lys Ala Ala Asp Pro Arg Phe Arg Pro Arg Trp Lys Val Ile Leu Thr 
        35                  40                  45              


Phe Phe Val Gly Ala Ala Ile Leu Trp Leu Leu Cys Ser His Arg Pro 
    50                  55                  60                  


Ala Pro Gly Arg Pro Pro Thr His Asn Ala His Asn Trp Arg Leu Gly 
65                  70                  75                  80  


Gln Ala Pro Ala Asn Trp Tyr Asn Asp Thr Tyr Pro Leu Ser Pro Pro 
                85                  90                  95      


Gln Arg Thr Pro Ala Gly Ile Arg Tyr Arg Ile Ala Val Ile Ala Asp 
            100                 105                 110         


Leu Asp Thr Glu Ser Arg Ala Gln Glu Glu Asn Thr Trp Phe Ser Tyr 
        115                 120                 125             


Leu Lys Lys Gly Tyr Leu Thr Leu Ser Asp Ser Gly Asp Lys Val Ala 
    130                 135                 140                 


Val Glu Trp Asp Lys Asp His Gly Val Leu Glu Ser His Leu Ala Glu 
145                 150                 155                 160 


Lys Gly Arg Gly Met Glu Leu Ser Asp Leu Ile Val Phe Asn Gly Lys 
                165                 170                 175     


Leu Tyr Ser Val Asp Asp Arg Thr Gly Val Val Tyr Gln Ile Glu Gly 
            180                 185                 190         


Ser Lys Ala Val Pro Trp Val Ile Leu Ser Asp Gly Asp Gly Thr Val 
        195                 200                 205             


Glu Lys Gly Phe Lys Ala Glu Trp Leu Ala Val Lys Asp Glu Arg Leu 
    210                 215                 220                 


Tyr Val Gly Gly Leu Gly Lys Glu Trp Thr Thr Thr Thr Gly Asp Val 
225                 230                 235                 240 


Val Asn Glu Asn Pro Glu Trp Val Lys Val Val Gly Tyr Lys Gly Ser 
                245                 250                 255     


Val Asp His Glu Asn Trp Val Ser Asn Tyr Asn Ala Leu Arg Ala Ala 
            260                 265                 270         


Ala Gly Ile Gln Pro Pro Gly Tyr Leu Ile His Glu Ser Ala Cys Trp 
        275                 280                 285             


Ser Asp Thr Leu Gln Arg Trp Phe Phe Leu Pro Arg Arg Ala Ser Gln 
    290                 295                 300                 


Glu Arg Tyr Ser Glu Lys Asp Asp Glu Arg Lys Gly Ala Asn Leu Leu 
305                 310                 315                 320 


Leu Ser Ala Ser Pro Asp Phe Gly Asp Ile Ala Val Ser His Val Gly 
                325                 330                 335     


Ala Val Val Pro Thr His Gly Phe Ser Ser Phe Lys Phe Ile Pro Asn 
            340                 345                 350         


Thr Asp Asp Gln Ile Ile Val Ala Leu Lys Ser Glu Glu Asp Ser Gly 
        355                 360                 365             


Arg Val Ala Ser Tyr Ile Met Ala Phe Thr Leu Asp Gly Arg Phe Leu 
    370                 375                 380                 


Leu Pro Glu Thr Lys Ile Gly Ser Val Lys Tyr Glu Gly Ile Glu Phe 
385                 390                 395                 400 


Ile 
    


<210>  1962
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  1962

Met Glu Ala Phe Ala Leu Gly Pro Ala Arg Arg Gly Arg Arg Arg Thr 
1               5                   10                  15      


Arg Ala Ala Gly Ser Leu Leu Ser Arg Ala Ala Ile Leu Leu Phe Ile 
            20                  25                  30          


Ser Ala Phe Leu Val Arg Val Pro Ser Ser Val Gly His Leu Val Arg 
        35                  40                  45              


Leu Pro Arg Ala Phe Arg Leu Thr Lys Asp Ser Val Lys Ile Val Gly 
    50                  55                  60                  


Ser Thr Ser Phe Pro Val Lys Ala Tyr Val Met Leu His Gln Lys Ser 
65                  70                  75                  80  


Pro His Val Leu Cys Val Thr Gln Gln Leu Arg Asn Ala Glu Leu Ile 
                85                  90                  95      


Asp Pro Ser Phe Gln Trp Tyr Gly Pro Lys Gly Lys Val Val Ser Glu 
            100                 105                 110         


Asn Arg Thr Ala Gln Ile Thr Ser Thr Gly Ser Leu Val Phe Gln Asn 
        115                 120                 125             


Phe Glu Glu Ser Met Ser Gly Ile Tyr Thr Cys Phe Leu Glu Tyr Lys 
    130                 135                 140                 


Pro Thr Val Glu Glu Ile Val Lys Arg Leu Gln Leu Lys Tyr Ala Ile 
145                 150                 155                 160 


Tyr Ala Tyr Arg Glu Pro His Tyr Tyr Tyr Gln Phe Thr Ala Arg Tyr 
                165                 170                 175     


His Ala Ala Pro Cys Asn Ser Ile Tyr Asn Ile Ser Phe Glu Lys Lys 
            180                 185                 190         


Leu Leu Gln Ile Leu Ser Lys Leu Leu Leu Asp Leu Ser Cys Glu Ile 
        195                 200                 205             


Ser Leu Leu Lys Ser Glu Cys His Arg Val Lys Met Gln Arg Ala Gly 
    210                 215                 220                 


Leu Gln Asn Glu Leu Phe Phe Ala Phe Ser Val Ser Ser Leu Asp Thr 
225                 230                 235                 240 


Glu Lys Gly Pro Lys Arg Cys Thr Asp His Asn Cys Glu Pro Tyr Lys 
                245                 250                 255     


Arg Leu Phe Lys Ala Lys Asn Leu Ile Glu Arg Phe Phe Asn Gln Gln 
            260                 265                 270         


Val Glu Ile Leu Gly Arg Arg Ala Glu Gln Leu Pro Gln Ile Tyr Tyr 
        275                 280                 285             


Ile Glu Gly Thr Leu Gln Met Val Trp Ile Asn Arg Cys Phe Pro Gly 
    290                 295                 300                 


Tyr Gly Met Asn Val Gln Gln His Pro Lys Cys Pro Glu Cys Cys Val 
305                 310                 315                 320 


Ile Cys Ser Pro Gly Ser Tyr Asn Pro Arg Asp Gly Ile His Cys Leu 
                325                 330                 335     


Gln Cys Asn Ser Ser Leu Val Tyr Gly Ala Lys Thr Cys Leu 
            340                 345                 350 


<210>  1963
<211>  805
<212>  PRT
<213>  Homo sapiens

<400>  1963

Met Ala Ser Pro Thr Leu Ser Pro Asp Ser Ser Ser Gln Glu Ala Leu 
1               5                   10                  15      


Ser Ala Pro Thr Cys Ser Pro Thr Ser Asp Ser Glu Asn Leu Ser Pro 
            20                  25                  30          


Asp Glu Leu Glu Leu Leu Ala Lys Leu Glu Glu Gln Asn Arg Leu Leu 
        35                  40                  45              


Glu Ala Asp Ser Lys Ser Met Arg Ser Met Asn Gly Ser Arg Arg Asn 
    50                  55                  60                  


Ser Gly Ser Ser Leu Val Ser Ser Ser Ser Ala Ser Ser Asn Leu Ser 
65                  70                  75                  80  


His Leu Glu Glu Asp Thr Trp Ile Leu Trp Gly Arg Ile Ala Asn Glu 
                85                  90                  95      


Trp Glu Glu Trp Arg Arg Arg Lys Glu Lys Leu Leu Lys Glu Leu Ile 
            100                 105                 110         


Arg Lys Gly Ile Pro His His Phe Arg Ala Ile Val Trp Gln Leu Leu 
        115                 120                 125             


Cys Ser Ala Thr Asp Met Pro Val Lys Asn Gln Tyr Ser Glu Leu Leu 
    130                 135                 140                 


Lys Met Ser Ser Pro Cys Glu Lys Leu Ile Arg Arg Asp Ile Ala Arg 
145                 150                 155                 160 


Thr Tyr Pro Glu His Glu Phe Phe Lys Gly Gln Asp Ser Leu Gly Gln 
                165                 170                 175     


Glu Val Leu Phe Asn Val Met Lys Ala Tyr Ser Leu Val Asp Arg Glu 
            180                 185                 190         


Val Gly Tyr Cys Gln Gly Ser Ala Phe Ile Val Gly Leu Leu Leu Met 
        195                 200                 205             


Gln Met Pro Glu Glu Glu Ala Phe Cys Val Phe Val Arg Leu Met Gln 
    210                 215                 220                 


Glu Tyr Arg Leu Arg Glu Leu Phe Lys Pro Ser Met Ala Glu Leu Gly 
225                 230                 235                 240 


Leu Cys Ile Tyr Gln Phe Glu Tyr Met Leu Gln Glu Gln Leu Pro Asp 
                245                 250                 255     


Leu Asn Thr His Phe Arg Ser Gln Ser Phe His Thr Ser Met Tyr Ala 
            260                 265                 270         


Ser Ser Trp Phe Leu Thr Leu Phe Leu Thr Thr Phe Pro Leu Pro Val 
        275                 280                 285             


Ala Thr Arg Val Phe Asp Ile Phe Met Tyr Glu Gly Leu Glu Ile Val 
    290                 295                 300                 


Phe Arg Val Gly Leu Ala Leu Leu Gln Val Asn Gln Ala Glu Leu Met 
305                 310                 315                 320 


Gln Leu Asp Met Glu Gly Met Ser Gln Tyr Phe Gln Arg Val Ile Pro 
                325                 330                 335     


His Gln Phe Asp Ser Cys Pro Asp Lys Leu Val Leu Lys Ala Tyr Gln 
            340                 345                 350         


Val Lys Tyr Asn Pro Lys Lys Met Lys Arg Leu Glu Lys Glu Tyr Ala 
        355                 360                 365             


Ala Met Lys Ser Lys Glu Met Glu Glu Gln Ile Glu Ile Lys Arg Leu 
    370                 375                 380                 


Arg Thr Glu Asn Arg Leu Leu Lys Gln Arg Ile Glu Thr Leu Glu Lys 
385                 390                 395                 400 


Glu Ser Ala Ala Leu Ala Asp Arg Leu Ile Gln Gly Gln Val Thr Arg 
                405                 410                 415     


Ala Gln Glu Ala Glu Glu Asn Tyr Val Ile Lys Arg Glu Leu Ala Val 
            420                 425                 430         


Val Arg Gln Gln Cys Ser Ser Ala Ala Glu Asp Leu Gln Lys Ala Gln 
        435                 440                 445             


Ser Thr Ile Arg Gln Leu Gln Glu Gln Gln Glu Asn Pro Arg Leu Thr 
    450                 455                 460                 


Glu Asp Phe Val Ser His Leu Glu Thr Glu Leu Glu Gln Ser Arg Leu 
465                 470                 475                 480 


Arg Glu Thr Glu Thr Leu Gly Ala Leu Arg Glu Met Gln Asp Lys Val 
                485                 490                 495     


Leu Asp Met Glu Lys Arg Asn Ser Ser Leu Pro Asp Glu Asn Asn Val 
            500                 505                 510         


Ala Gln Leu Gln Glu Glu Leu Lys Ala Leu Lys Val Arg Glu Gly Gln 
        515                 520                 525             


Ala Val Ala Ser Thr Arg Glu Leu Lys Leu Gln Leu Gln Glu Leu Ser 
    530                 535                 540                 


Asp Thr Trp Gln Ala His Leu Ala Arg Gly Gly Arg Trp Lys Glu Ser 
545                 550                 555                 560 


Pro Arg Lys Leu Val Val Gly Glu Leu Gln Asp Glu Leu Met Ser Val 
                565                 570                 575     


Arg Leu Arg Glu Ala Gln Ala Leu Ala Glu Gly Arg Glu Leu Arg Gln 
            580                 585                 590         


Arg Val Val Glu Leu Glu Thr Gln Asp His Ile His Arg Asn Leu Leu 
        595                 600                 605             


Asn Arg Val Glu Ala Glu Arg Ala Ala Leu Gln Glu Lys Leu Gln Tyr 
    610                 615                 620                 


Leu Ala Ala Gln Asn Lys Gly Leu Gln Thr Gln Leu Ser Glu Ser Arg 
625                 630                 635                 640 


Arg Lys Gln Ala Glu Ala Glu Cys Lys Ser Lys Glu Glu Val Met Ala 
                645                 650                 655     


Val Arg Leu Arg Glu Ala Asp Ser Met Ala Ala Val Ala Glu Met Arg 
            660                 665                 670         


Gln Arg Ile Ala Glu Leu Glu Ile Gln Arg Glu Glu Gly Arg Ile Gln 
        675                 680                 685             


Gly Gln Leu Asn His Ser Asp Ser Ser Gln Tyr Ile Arg Glu Leu Lys 
    690                 695                 700                 


Asp Gln Ile Glu Glu Leu Lys Ala Glu Val Arg Leu Leu Lys Gly Pro 
705                 710                 715                 720 


Pro Pro Phe Glu Asp Pro Leu Ala Phe Asp Gly Leu Ser Leu Ala Arg 
                725                 730                 735     


His Leu Asp Glu Asp Ser Leu Pro Ser Ser Asp Glu Glu Leu Leu Gly 
            740                 745                 750         


Val Gly Val Gly Ala Ala Leu Gln Asp Ala Leu Tyr Pro Leu Ser Pro 
        755                 760                 765             


Arg Asp Ala Arg Phe Phe Arg Arg Leu Glu Arg Pro Ala Lys Asp Ser 
    770                 775                 780                 


Glu Gly Ser Ser Asp Ser Asp Ala Asp Glu Leu Ala Ala Pro Tyr Ser 
785                 790                 795                 800 


Gln Gly Leu Asp Asn 
                805 


<210>  1964
<211>  607
<212>  PRT
<213>  Homo sapiens

<400>  1964

Met Gly Lys Gly Arg Ala Gly Arg Val Gly Thr Thr Ala Leu Pro Pro 
1               5                   10                  15      


Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala Ala Gly Ser Lys Leu 
            20                  25                  30          


Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser Ser Leu Arg Phe Lys 
        35                  40                  45              


Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys Asn Lys Pro Gln Asn 
    50                  55                  60                  


Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu Leu Arg Ile Asn Lys 
65                  70                  75                  80  


Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys Lys Val Ile Ser Lys 
                85                  90                  95      


Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr Ile Val Glu Ser Asn 
            100                 105                 110         


Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu Gly Ala Tyr Val Ser 
        115                 120                 125             


Ser Ala Thr Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys 
    130                 135                 140                 


Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met 
145                 150                 155                 160 


Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn 
                165                 170                 175     


Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr 
            180                 185                 190         


Lys His Leu Gly Ile Glu Phe Met Glu Ala Glu Glu Leu Tyr Gln Lys 
        195                 200                 205             


Arg Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly 
    210                 215                 220                 


Ile Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys 
225                 230                 235                 240 


Leu His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met 
                245                 250                 255     


Met Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn 
            260                 265                 270         


Val Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu 
        275                 280                 285             


His Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr 
    290                 295                 300                 


Thr Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His 
305                 310                 315                 320 


Ser Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser 
                325                 330                 335     


Val Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr 
            340                 345                 350         


Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys 
        355                 360                 365             


Asn Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp 
    370                 375                 380                 


Ser Pro His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala Arg 
385                 390                 395                 400 


Met Ser Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro Pro 
                405                 410                 415     


Ser Glu Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro Ser 
            420                 425                 430         


Met Ala Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu Val 
        435                 440                 445             


Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln Gln 
    450                 455                 460                 


Phe Ser Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu Pro 
465                 470                 475                 480 


Ala Ser Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr Gln 
                485                 490                 495     


Glu Tyr Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser Arg 
            500                 505                 510         


Arg Ala Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu Glu 
        515                 520                 525             


Val Asp Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu Thr 
    530                 535                 540                 


Glu Asp Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln Asn 
545                 550                 555                 560 


Pro Leu Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala Asp 
                565                 570                 575     


Ser Arg Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile Gln 
            580                 585                 590         


Ala Arg Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
        595                 600                 605         


<210>  1965
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  1965

Met Gln Ile Pro Lys His Ile Ser Ile Glu Asp Ile Thr Ala Thr Ser 
1               5                   10                  15      


Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys Glu 
            20                  25                  30          


Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp Leu 
        35                  40                  45              


Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Gln Pro Gly Phe Thr Gly 
    50                  55                  60                  


Ala Arg Cys Thr Glu Asn Val Pro Met Lys Val Gln Asn Gln Glu Lys 
65                  70                  75                  80  


Ala Glu Glu Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly Ile Cys 
                85                  90                  95      


Ile Ala Leu Leu Val Val Gly Ile Met Cys Val Val Ala Tyr Cys Lys 
            100                 105                 110         


Thr Lys Lys Gln Arg Lys Lys Leu His Asp Arg Leu Arg Gln Ser Leu 
        115                 120                 125             


Arg Ser Glu Arg Asn Asn Met Met Asn Ile Ala Asn Gly Pro His His 
    130                 135                 140                 


Pro Asn Pro Pro Pro Glu Asn Val Gln Leu Val Asn Gln Tyr Val Ser 
145                 150                 155                 160 


Lys Asn Val Ile Ser Ser Glu His Ile Val Glu Arg Glu Ala Glu Thr 
                165                 170                 175     


Ser Phe Ser Thr Ser His Tyr Thr Ser Thr Ala His His Ser Thr Thr 
            180                 185                 190         


Val Thr Gln Thr Pro Ser His Ser Trp Ser Asn Gly His Thr Glu Ser 
        195                 200                 205             


Ile Leu Ser Glu Ser His Ser Val Ile Val Met Ser Ser Val Glu Asn 
    210                 215                 220                 


Ser Arg His Ser Ser Pro Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly 
225                 230                 235                 240 


Thr Gly Gly Pro Arg Glu Cys Asn Ser Phe Leu Arg His Ala Arg Glu 
                245                 250                 255     


Thr Pro Asp Ser Tyr Arg Asp Ser Pro His Ser Glu Arg His Asn Leu 
            260                 265                 270         


Ile Ala Glu Leu Arg Arg Asn Lys Ala His Arg Ser Lys Cys Met Gln 
        275                 280                 285             


Ile Gln Leu Ser Ala Thr His Leu Arg Ser Ser Ser Ile Pro His Leu 
    290                 295                 300                 


Gly Phe Ile Leu 
305             


<210>  1966
<211>  624
<212>  PRT
<213>  Homo sapiens

<400>  1966

Met Gly Lys Gly Arg Ala Gly Arg Val Gly Thr Thr Ala Leu Pro Pro 
1               5                   10                  15      


Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala Ala Gly Ser Lys Leu 
            20                  25                  30          


Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser Ser Leu Arg Phe Lys 
        35                  40                  45              


Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys Asn Lys Pro Gln Asn 
    50                  55                  60                  


Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu Leu Arg Ile Asn Lys 
65                  70                  75                  80  


Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys Lys Val Ile Ser Lys 
                85                  90                  95      


Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr Ile Val Glu Ser Asn 
            100                 105                 110         


Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu Gly Ala Tyr Val Ser 
        115                 120                 125             


Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr Glu Gly Ala Asn Thr 
    130                 135                 140                 


Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys 
145                 150                 155                 160 


Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe 
                165                 170                 175     


Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro 
            180                 185                 190         


Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe 
        195                 200                 205             


Tyr Lys His Leu Gly Ile Glu Phe Met Glu Ala Glu Glu Leu Tyr Gln 
    210                 215                 220                 


Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val 
225                 230                 235                 240 


Gly Ile Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys 
                245                 250                 255     


Lys Leu His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn 
            260                 265                 270         


Met Met Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu 
        275                 280                 285             


Asn Val Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser 
    290                 295                 300                 


Glu His Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His 
305                 310                 315                 320 


Tyr Thr Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser 
                325                 330                 335     


His Ser Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His 
            340                 345                 350         


Ser Val Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro 
        355                 360                 365             


Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu 
    370                 375                 380                 


Cys Asn Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg 
385                 390                 395                 400 


Asp Ser Pro His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala 
                405                 410                 415     


Arg Met Ser Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro 
            420                 425                 430         


Pro Ser Glu Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro 
        435                 440                 445             


Ser Met Ala Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu 
    450                 455                 460                 


Val Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln 
465                 470                 475                 480 


Gln Phe Ser Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu 
                485                 490                 495     


Pro Ala Ser Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr 
            500                 505                 510         


Gln Glu Tyr Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser 
        515                 520                 525             


Arg Arg Ala Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu 
    530                 535                 540                 


Glu Val Asp Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu 
545                 550                 555                 560 


Thr Glu Asp Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln 
                565                 570                 575     


Asn Pro Leu Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala 
            580                 585                 590         


Asp Ser Arg Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile 
        595                 600                 605             


Gln Ala Arg Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
    610                 615                 620                 


<210>  1967
<211>  590
<212>  PRT
<213>  Homo sapiens

<400>  1967

Met Gly Lys Gly Arg Ala Gly Arg Val Gly Thr Thr Ala Leu Pro Pro 
1               5                   10                  15      


Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala Ala Gly Ser Lys Leu 
            20                  25                  30          


Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser Ser Leu Arg Phe Lys 
        35                  40                  45              


Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys Asn Lys Pro Gln Asn 
    50                  55                  60                  


Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu Leu Arg Ile Asn Lys 
65                  70                  75                  80  


Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys Lys Val Ile Ser Lys 
                85                  90                  95      


Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr Ile Val Glu Ser Asn 
            100                 105                 110         


Ala Thr Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala 
        115                 120                 125             


Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val 
    130                 135                 140                 


Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu 
145                 150                 155                 160 


Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr Lys 
                165                 170                 175     


His Leu Gly Ile Glu Phe Met Glu Ala Glu Glu Leu Tyr Gln Lys Arg 
            180                 185                 190         


Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly Ile 
        195                 200                 205             


Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys Leu 
    210                 215                 220                 


His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met Met 
225                 230                 235                 240 


Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn Val 
                245                 250                 255     


Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu His 
            260                 265                 270         


Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr Thr 
        275                 280                 285             


Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His Ser 
    290                 295                 300                 


Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser Val 
305                 310                 315                 320 


Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr Gly 
                325                 330                 335     


Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys Asn 
            340                 345                 350         


Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp Ser 
        355                 360                 365             


Pro His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala Arg Met 
    370                 375                 380                 


Ser Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro Pro Ser 
385                 390                 395                 400 


Glu Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro Ser Met 
                405                 410                 415     


Ala Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu Val Thr 
            420                 425                 430         


Pro Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln Gln Phe 
        435                 440                 445             


Ser Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu Pro Ala 
    450                 455                 460                 


Ser Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr Gln Glu 
465                 470                 475                 480 


Tyr Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser Arg Arg 
                485                 490                 495     


Ala Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu Glu Val 
            500                 505                 510         


Asp Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu Thr Glu 
        515                 520                 525             


Asp Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln Asn Pro 
    530                 535                 540                 


Leu Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala Asp Ser 
545                 550                 555                 560 


Arg Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile Gln Ala 
                565                 570                 575     


Arg Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
            580                 585                 590 


<210>  1968
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  1968

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Ala Thr Ser Thr Ser Thr Thr Gly Thr Ser 
145                 150                 155                 160 


His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly 
                165                 170                 175     


Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu 
            180                 185                 190         


Cys Lys 
        


<210>  1969
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  1969

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
    210                 215                 220                 


Val Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Lys Arg Val 
225                 230                 235                 240 


Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly Ile Met 
                245                 250                 255     


Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys Leu His 
            260                 265                 270         


Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met Met Asn 
        275                 280                 285             


Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn Val Gln 
    290                 295                 300                 


Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu His Ile 
305                 310                 315                 320 


Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr Thr Ser 
                325                 330                 335     


Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His Ser Trp 
            340                 345                 350         


Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser Val Ile 
        355                 360                 365             


Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr Gly Gly 
    370                 375                 380                 


Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys Asn Ser 
385                 390                 395                 400 


Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp Ser Pro 
                405                 410                 415     


His Ser Glu Arg His Asn Leu Ile Ala Glu Leu Arg Arg Asn Lys Ala 
            420                 425                 430         


His Arg Ser Lys Cys Met Gln Ile Gln Leu Ser Ala Thr His Leu Arg 
        435                 440                 445             


Ser Ser Ser Ile Pro His Leu Gly Phe Ile Leu 
    450                 455                 


<210>  1970
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  1970

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Ala Thr Ser Thr Ser Thr Thr Gly Thr Ser His 
    130                 135                 140                 


Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly 
145                 150                 155                 160 


Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys 
                165                 170                 175     


Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val Met 
            180                 185                 190         


Ala Ser Phe Tyr Ser Thr Ser Thr Pro Phe Leu Ser Leu Pro Glu 
        195                 200                 205         


<210>  1971
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  1971

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Ala Thr Ser Thr Ser Thr Thr Gly Thr Ser His 
    130                 135                 140                 


Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly 
145                 150                 155                 160 


Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys 
                165                 170                 175     


Lys 
    


<210>  1972
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  1972

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
    210                 215                 220                 


Val Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Lys Arg Val 
225                 230                 235                 240 


Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly Ile Met 
                245                 250                 255     


Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys Leu His 
            260                 265                 270         


Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met Met Asn 
        275                 280                 285             


Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn Val Gln 
    290                 295                 300                 


Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu His Ile 
305                 310                 315                 320 


Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr Thr Ser 
                325                 330                 335     


Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His Ser Trp 
            340                 345                 350         


Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser Val Ile 
        355                 360                 365             


Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr Gly Gly 
    370                 375                 380                 


Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys Asn Ser 
385                 390                 395                 400 


Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp Ser Pro 
                405                 410                 415     


His Ser Glu Arg 
            420 


<210>  1973
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  1973

Met Ala Cys Ile Leu Lys Arg Lys Ser Val Ile Ala Val Ser Phe Ile 
1               5                   10                  15      


Ala Ala Phe Leu Phe Leu Leu Val Val Arg Leu Val Asn Glu Val Asn 
            20                  25                  30          


Phe Pro Leu Leu Leu Asn Cys Phe Gly Gln Pro Gly Thr Lys Trp Ile 
        35                  40                  45              


Pro Phe Ser Tyr Thr Tyr Arg Arg Pro Leu Arg Thr His Tyr Gly Tyr 
    50                  55                  60                  


Ile Asn Val Lys Thr Gln Glu Pro Leu Gln Leu Asp Cys Asp Leu Cys 
65                  70                  75                  80  


Ala Ile Val Ser Asn Ser Gly Gln Met Val Gly Gln Lys Val Gly Asn 
                85                  90                  95      


Glu Ile Asp Arg Ser Ser Cys Ile Trp Arg Met Asn Asn Ala Pro Thr 
            100                 105                 110         


Lys Gly Tyr Glu Glu Asp Val Gly Arg Met Thr Met Ile Arg Val Val 
        115                 120                 125             


Ser His Thr Ser Val Pro Leu Leu Leu Lys Asn Pro Asp Tyr Phe Phe 
    130                 135                 140                 


Lys Glu Ala Asn Thr Thr Ile Tyr Val Ile Trp Gly Pro Phe Arg Asn 
145                 150                 155                 160 


Met Arg Lys Asp Gly Asn Gly Ile Val Tyr Asn Met Leu Lys Lys Thr 
                165                 170                 175     


Val Gly Ile Tyr Pro Asn Ala Gln Ile Tyr Val Thr Thr Glu Lys Arg 
            180                 185                 190         


Met Ser Tyr Cys Asp Gly Val Phe Lys Lys Glu Thr Gly Lys Asp Ser 
        195                 200                 205             


Thr Glu 
    210 


<210>  1974
<211>  820
<212>  PRT
<213>  Homo sapiens

<400>  1974

Met Phe Ser Gly Phe Asn Val Phe Arg Val Gly Ile Ser Phe Val Ile 
1               5                   10                  15      


Met Cys Ile Phe Tyr Met Pro Thr Val Asn Ser Leu Pro Glu Leu Ser 
            20                  25                  30          


Pro Gln Lys Tyr Phe Ser Thr Leu Gln Pro Gly Lys Ala Ser Leu Ala 
        35                  40                  45              


Tyr Phe Cys Gln Ala Asp Ser Pro Arg Thr Ser Val Phe Leu Glu Glu 
    50                  55                  60                  


Leu Asn Glu Ala Val Arg Pro Leu Gln Asp Tyr Gly Ile Ser Val Ala 
65                  70                  75                  80  


Lys Val Asn Cys Val Lys Glu Glu Ile Ser Arg Tyr Cys Gly Lys Glu 
                85                  90                  95      


Lys Asp Leu Met Lys Ala Tyr Leu Phe Lys Gly Asn Ile Leu Leu Arg 
            100                 105                 110         


Glu Phe Pro Thr Asp Thr Leu Phe Asp Val Asn Ala Ile Val Ala His 
        115                 120                 125             


Val Leu Phe Glu Val Lys Tyr Ile Thr Asn Leu Glu Asp Leu Gln Asn 
    130                 135                 140                 


Ile Glu Asn Ala Leu Lys Gly Lys Ala Asn Ile Ile Phe Ser Tyr Val 
145                 150                 155                 160 


Arg Ala Ile Gly Ile Pro Glu His Arg Ala Val Met Glu Ala Ala Phe 
                165                 170                 175     


Val Tyr Gly Thr Thr Tyr Gln Phe Val Leu Thr Thr Glu Ile Ala Leu 
            180                 185                 190         


Leu Glu Ser Ile Gly Ser Glu Asp Val Glu Tyr Ala His Leu Tyr Phe 
        195                 200                 205             


Phe His Cys Lys Leu Val Leu Asp Leu Thr Gln Gln Cys Arg Arg Thr 
    210                 215                 220                 


Leu Met Glu Gln Pro Leu Thr Thr Leu Asn Ile His Leu Phe Ile Lys 
225                 230                 235                 240 


Thr Met Lys Ala Pro Leu Leu Thr Glu Val Ala Glu Asp Pro Gln Gln 
                245                 250                 255     


Val Ser Thr Val His Leu Gln Leu Gly Leu Pro Leu Val Phe Ile Val 
            260                 265                 270         


Ser Gln Gln Ala Thr Tyr Glu Ala Asp Arg Arg Thr Ala Glu Trp Val 
        275                 280                 285             


Ala Trp Arg Leu Leu Gly Lys Ala Gly Val Leu Leu Leu Leu Arg Asp 
    290                 295                 300                 


Ser Leu Glu Val Asn Ile Pro Gln Asp Ala Asn Val Val Phe Lys Arg 
305                 310                 315                 320 


Ala Glu Glu Gly Val Pro Val Glu Phe Leu Val Leu His Asp Val Asp 
                325                 330                 335     


Leu Ile Ile Ser His Val Glu Asn Asn Met His Ile Glu Glu Ile Gln 
            340                 345                 350         


Glu Asp Glu Asp Asn Asp Met Glu Gly Pro Asp Ile Asp Val Gln Asp 
        355                 360                 365             


Asp Glu Val Ala Glu Thr Val Phe Arg Asp Arg Lys Arg Lys Leu Pro 
    370                 375                 380                 


Leu Glu Leu Thr Val Glu Leu Thr Glu Glu Thr Phe Asn Ala Thr Val 
385                 390                 395                 400 


Met Ala Ser Asp Ser Ile Val Leu Phe Tyr Ala Gly Trp Gln Ala Val 
                405                 410                 415     


Ser Met Ala Phe Leu Gln Ser Tyr Ile Asp Val Ala Val Lys Leu Lys 
            420                 425                 430         


Gly Thr Ser Thr Met Leu Leu Thr Arg Ile Asn Cys Ala Asp Trp Ser 
        435                 440                 445             


Asp Val Cys Thr Lys Gln Asn Val Thr Glu Phe Pro Ile Ile Lys Met 
    450                 455                 460                 


Tyr Lys Lys Gly Glu Asn Pro Val Ser Tyr Ala Gly Met Leu Gly Thr 
465                 470                 475                 480 


Glu Asp Leu Leu Lys Phe Ile Gln Leu Asn Arg Ile Ser Tyr Pro Val 
                485                 490                 495     


Asn Ile Thr Ser Ile Gln Glu Ala Glu Glu Tyr Leu Ser Gly Glu Leu 
            500                 505                 510         


Tyr Lys Asp Leu Ile Leu Tyr Ser Ser Val Ser Val Leu Gly Leu Phe 
        515                 520                 525             


Ser Pro Thr Met Lys Thr Ala Lys Glu Asp Phe Ser Glu Ala Gly Asn 
    530                 535                 540                 


Tyr Leu Lys Gly Tyr Val Ile Thr Gly Ile Tyr Ser Glu Glu Asp Val 
545                 550                 555                 560 


Leu Leu Leu Ser Thr Lys Tyr Ala Ala Ser Leu Pro Ala Leu Leu Leu 
                565                 570                 575     


Ala Arg His Thr Glu Gly Lys Ile Glu Ser Ile Pro Leu Ala Ser Thr 
            580                 585                 590         


His Ala Gln Asp Ile Val Gln Ile Ile Thr Asp Ala Leu Leu Glu Met 
        595                 600                 605             


Phe Pro Glu Ile Thr Val Glu Asn Leu Pro Ser Tyr Phe Arg Leu Gln 
    610                 615                 620                 


Lys Pro Leu Leu Ile Leu Phe Ser Asp Gly Thr Val Asn Pro Gln Tyr 
625                 630                 635                 640 


Lys Lys Ala Ile Leu Thr Leu Val Lys Gln Lys Tyr Leu Asp Ser Phe 
                645                 650                 655     


Thr Pro Cys Trp Leu Asn Leu Lys Asn Thr Pro Val Gly Arg Gly Ile 
            660                 665                 670         


Leu Arg Ala Tyr Phe Asp Pro Leu Pro Pro Leu Pro Leu Leu Val Leu 
        675                 680                 685             


Val Asn Leu His Ser Gly Gly Gln Val Phe Ala Phe Pro Ser Asp Gln 
    690                 695                 700                 


Ala Ile Ile Glu Glu Asn Leu Val Leu Trp Leu Lys Lys Leu Glu Ala 
705                 710                 715                 720 


Gly Leu Glu Asn His Ile Thr Ile Leu Pro Ala Gln Glu Trp Lys Pro 
                725                 730                 735     


Pro Leu Pro Ala Tyr Asp Phe Leu Ser Met Ile Asp Ala Ala Thr Ser 
            740                 745                 750         


Gln Arg Gly Thr Arg Lys Val Pro Lys Cys Met Lys Glu Thr Asp Val 
        755                 760                 765             


Gln Glu Asn Asp Lys Glu Gln His Glu Asp Lys Ser Ala Val Arg Lys 
    770                 775                 780                 


Glu Pro Ile Glu Thr Leu Arg Ile Lys His Trp Asn Arg Ser Asn Trp 
785                 790                 795                 800 


Phe Lys Glu Ala Glu Lys Ser Phe Arg Arg Asp Lys Glu Leu Gly Cys 
                805                 810                 815     


Ser Lys Val Asn 
            820 


<210>  1975
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  1975

Met Ser Arg Ala Gln Ile Trp Ala Leu Val Ser Gly Val Gly Gly Phe 
1               5                   10                  15      


Gly Ala Leu Val Ala Ala Thr Thr Ser Asn Glu Trp Lys Val Thr Thr 
            20                  25                  30          


Arg Ala Ser Ser Val Ile Thr Ala Thr Trp Val Tyr Gln Gly Leu Trp 
        35                  40                  45              


Met Asn Cys Ala Gly Tyr Ile Gln Ala Cys Arg Gly Leu Met Ile Ala 
    50                  55                  60                  


Ala Val Ser Leu Gly Phe Phe Gly Ser Ile Phe Ala Leu Phe Gly Met 
65                  70                  75                  80  


Lys Cys Thr Lys Val Gly Gly Ser Asp Lys Ala Lys Ala Lys Ile Ala 
                85                  90                  95      


Cys Leu Ala Gly Ile Val Phe Ile Leu Ser Gly Leu Cys Ser Met Thr 
            100                 105                 110         


Gly Cys Ser Leu Tyr Ala Asn Lys Ile Thr Thr Glu Phe Phe Asp Pro 
        115                 120                 125             


Leu Phe Val Glu Gln Lys Tyr Glu Leu Gly Ala Ala Leu Phe Ile Gly 
    130                 135                 140                 


Trp Ala Gly Ala Ser Leu Cys Ile Ile Gly Gly Val Ile Phe Cys Phe 
145                 150                 155                 160 


Ser Ile Ser Asp Asn Asn Lys Thr Pro Arg Tyr Thr Tyr Asn Gly Ala 
                165                 170                 175     


Thr Ser Val Met Ser Ser Arg Thr Lys Tyr His Gly Gly Glu Asp Phe 
            180                 185                 190         


Lys Thr Thr Asn Pro Ser Lys Gln Phe Asp Lys Asn Ala Tyr Val 
        195                 200                 205         


<210>  1976
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  1976

Met Asn Tyr Ser Ile Thr Val Ser Ile Val Met Gly Ile Pro Thr Val 
1               5                   10                  15      


Lys Arg Glu Val Lys Ser Tyr Leu Ile Glu Thr Leu His Ser Leu Ile 
            20                  25                  30          


Asp Asn Leu Tyr Pro Glu Glu Lys Leu Asp Cys Val Ile Val Val Phe 
        35                  40                  45              


Ile Gly Glu Thr Asp Ile Asp Tyr Val His Gly Val Val Ala Asn Leu 
    50                  55                  60                  


Glu Lys Glu Phe Ser Lys Glu Ile Ser Ser Gly Leu Val Glu Val Ile 
65                  70                  75                  80  


Ser Pro Pro Glu Ser Tyr Tyr Pro Asp Leu Thr Asn Leu Lys Glu Thr 
                85                  90                  95      


Phe Gly Asp Ser Lys Glu Arg Val Arg Trp Arg Thr Lys Gln Asn Leu 
            100                 105                 110         


Asp Tyr Cys Phe Leu Met Met Tyr Ala Gln Glu Lys Gly Ile Tyr Tyr 
        115                 120                 125             


Ile Gln Leu Glu Asp Asp Ile Ile Val Lys Gln Asn Tyr Phe Asn Thr 
    130                 135                 140                 


Ile Lys Asn Phe Ala Leu Gln Leu Ser Ser Glu Glu Trp Met Ile Leu 
145                 150                 155                 160 


Glu Phe Ser Gln Leu Gly Phe Ile Gly Lys Met Phe Gln Ala Pro Asp 
                165                 170                 175     


Leu Thr Leu Ile Val Glu Phe Ile Phe Met Phe Tyr Lys Glu Lys Pro 
            180                 185                 190         


Ile Asp Trp Leu Leu Asp His Ile Leu Trp Val Lys Val Cys Asn Pro 
        195                 200                 205             


Glu Lys Asp Ala Lys His Cys Asp Arg Gln Lys Ala Asn Leu Arg Ile 
    210                 215                 220                 


Arg Phe Arg Pro Ser Leu Phe Gln His Val Gly Leu His Ser Ser Leu 
225                 230                 235                 240 


Ser Gly Lys Ile Gln Lys Leu Thr Asp Lys Asp Tyr Met Lys Pro Leu 
                245                 250                 255     


Leu Leu Lys Ile His Val Asn Pro Pro Ala Glu Val Ser Thr Ser Leu 
            260                 265                 270         


Lys Val Tyr Gln Gly His Thr Leu Glu Lys Thr Tyr Met Gly Glu Asp 
        275                 280                 285             


Phe Phe Trp Ala Ile Thr Pro Ile Ala Gly Asp Tyr Ile Leu Phe Lys 
    290                 295                 300                 


Phe Asp Lys Pro Val Asn Val Glu Ser Tyr Leu Phe His Ser Gly Asn 
305                 310                 315                 320 


Gln Glu His Pro Gly Asp Ile Leu Leu Asn Thr Thr Val Glu Val Leu 
                325                 330                 335     


Pro Phe Lys Ser Glu Gly Leu Glu Ile Ser Lys Glu Thr Lys Asp Lys 
            340                 345                 350         


Arg Leu Glu Asp Gly Tyr Phe Arg Ile Gly Lys Phe Glu Asn Gly Val 
        355                 360                 365             


Ala Glu Gly Met Val Asp Pro Ser Leu Asn Pro Ile Ser Ala Phe Arg 
    370                 375                 380                 


Leu Ser Val Ile Gln Asn Ser Ala Val Trp Ala Ile Leu Asn Glu Gln 
385                 390                 395                 400 


Arg Val Phe Ser Gly Trp Trp Gln Lys Ser Arg Asp Lys Ala Glu Gly 
                405                 410                 415     


Pro Gln Ala Pro Leu Leu Phe 
            420             


<210>  1977
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  1977

Met Pro Asp Thr Asn Ser Thr Ile Asn Leu Ser Leu Ser Thr Arg Val 
1               5                   10                  15      


Thr Leu Ala Phe Phe Met Ser Leu Val Ala Phe Ala Ile Met Leu Gly 
            20                  25                  30          


Asn Ala Leu Val Ile Leu Ala Phe Val Val Asp Lys Asn Leu Arg His 
        35                  40                  45              


Arg Ser Ser Tyr Phe Phe Leu Asn Leu Ala Ile Ser Asp Phe Phe Val 
    50                  55                  60                  


Gly Val Leu 
65          


<210>  1978
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  1978

Met Gly Pro Leu Thr Phe Met Asp Val Ala Ile Glu Phe Ser Leu Glu 
1               5                   10                  15      


Glu Trp Gln Cys Leu Asp Thr Ala Gln Arg Asn Val Tyr Arg His Val 
            20                  25                  30          


Met Leu Glu Asn Tyr Arg Asn Leu Val Phe Leu Asp Leu Ile Thr Cys 
        35                  40                  45              


Leu Glu Gln Gly Lys Glu Pro Trp Asn Met Lys Arg His Glu Met Val 
    50                  55                  60                  


Val Ala Lys His Ser Ala Val Ala Phe Thr Phe Asp Leu Ser Gly Leu 
65                  70                  75                  80  


Asn Ile Leu Ser Phe Gln Ser Ile Leu Pro Phe Val Ser Ala Leu Tyr 
                85                  90                  95      


Val Met Gly Asn Arg Asn Gln Cys Leu Gln Lys His Leu Glu Ala Arg 
            100                 105                 110         


Asn Lys Asp Leu Cys Val Leu Val Leu Pro Lys Thr Phe Gly 
        115                 120                 125     


<210>  1979
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  1979

Met Ala Lys Tyr Gln Gly Glu Val Gln Ser Leu Lys Leu Asp Asp Asp 
1               5                   10                  15      


Ser Val Ile Glu Gly Val Ser Asp Gln Val Leu Val Ala Val Val Val 
            20                  25                  30          


Ser Phe Ala Leu Ile Ala Thr Leu Val Tyr Ala Leu Phe Arg Asn Val 
        35                  40                  45              


His Gln Asn Ile His Pro Glu Asn Gln Glu Leu Val Arg Val Leu Arg 
    50                  55                  60                  


Glu Gln Leu Gln Thr Glu Gln Asp Ala Pro Ala Ala Thr Arg Gln Gln 
65                  70                  75                  80  


Phe Tyr Thr Asp Met Tyr Cys Pro Ile Cys Leu His Gln Ala Ser Phe 
                85                  90                  95      


Pro Val Glu Thr Asn Cys Gly His Leu Phe Cys Gly Ala Cys Ile Ile 
            100                 105                 110         


Ala Tyr Trp Arg Tyr Gly Ser Trp Leu Gly Ala Ile Ser Cys Pro Ile 
        115                 120                 125             


Cys Arg Gln Thr Val Thr Leu Leu Leu Thr Val Phe Gly Glu Asp Asp 
    130                 135                 140                 


Gln Ser Gln Asp Val Leu Arg Leu His Gln Asp Ile Asn Asp Tyr Asn 
145                 150                 155                 160 


Arg Arg Phe Ser Gly Gln Pro Arg Ser Ile Met Glu Arg Ile Met Asp 
                165                 170                 175     


Leu Pro Thr Leu Leu Arg His Ala Phe Arg Glu Met Phe Ser Val Gly 
            180                 185                 190         


Gly Leu Phe Trp Met Phe Arg Ile Arg Ile Ile Leu Cys Leu Met Gly 
        195                 200                 205             


Ala Phe Phe Tyr Leu Ile Ser Pro Leu Asp Phe Val Pro Glu Ala Leu 
    210                 215                 220                 


Phe Gly Ile Leu Gly Phe Leu Asp Asp Phe Phe Val Ile Phe Leu Leu 
225                 230                 235                 240 


Leu Ile Tyr Ile Ser Ile Met Tyr Arg Glu Val Ile Thr Gln Arg Leu 
                245                 250                 255     


Thr Arg 
        


<210>  1980
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  1980

Met Ala Lys Tyr Gln Gly Glu Val Gln Ser Leu Lys Leu Asp Asp Asp 
1               5                   10                  15      


Ser Val Ile Glu Gly Val Ser Asp Gln Val Leu Val Ala Val Val Val 
            20                  25                  30          


Ser Phe Ala Leu Ile Ala Thr Leu Val Tyr Ala Leu Phe Arg Asn Val 
        35                  40                  45              


His Gln Asn Ile His Pro Glu Asn Gln Glu Leu Val Arg Val Leu Arg 
    50                  55                  60                  


Glu Gln Leu Gln Thr Glu Gln Asp Ala Pro Ala Ala Thr Arg Gln Gln 
65                  70                  75                  80  


Phe Tyr Thr Asp Met Tyr Cys Pro Ile Cys Leu His Gln Ala Ser Phe 
                85                  90                  95      


Pro Val Glu Thr Asn Cys Gly His Leu Phe Cys Gly Ala Cys Ile Ile 
            100                 105                 110         


Ala Tyr Trp Arg Tyr Gly Ser Trp Leu Gly Ala Ile Ser Cys Pro Ile 
        115                 120                 125             


Cys Arg Gln Thr Gly Ser Ser Glu Lys Ser Ser Arg Ala Ser Glu Gln 
    130                 135                 140                 


Thr His Gln Glu Ala Val Ala Cys Leu Asp Thr Gln Asn Ser Pro Ala 
145                 150                 155                 160 


Cys Thr Val Gly Cys Arg Ser Gly Pro Gln His Ile Pro His Asp Arg 
                165                 170                 175     


Met Leu Pro Ser Ala Ser Pro Arg Leu Cys Phe Thr Leu Leu Asp Cys 
            180                 185                 190         


Val Ser Ile Leu Trp Phe Ser Gly 
        195                 200 


<210>  1981
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  1981

Met Tyr Cys Pro Ile Cys Leu His Gln Ala Ser Phe Pro Val Glu Thr 
1               5                   10                  15      


Asn Cys Gly His Leu Phe Cys Gly Ala Cys Ile Ile Ala Tyr Trp Arg 
            20                  25                  30          


Tyr Gly Ser Trp Leu Gly Ala Ile Ser Cys Pro Ile Cys Arg Gln Thr 
        35                  40                  45              


Val Thr Leu Leu Leu Thr Val Phe Gly Glu Asp Asp Gln Ser Gln Asp 
    50                  55                  60                  


Val Leu Arg Leu His Gln Asp Ile Asn Asp Tyr Asn Arg Arg Phe Ser 
65                  70                  75                  80  


Gly Gln Pro Arg Ser Ile Met Glu Arg Ile Met Asp Leu Pro Thr Leu 
                85                  90                  95      


Leu Arg His Ala Phe Arg Glu Met Phe Ser Val Gly Gly Leu Phe Trp 
            100                 105                 110         


Met Phe Arg Ile Arg Ile Ile Leu Cys Leu Met Gly Ala Phe Phe Tyr 
        115                 120                 125             


Leu Ile Ser Pro Leu Asp Phe Val Pro Glu Ala Leu Phe Gly Ile Leu 
    130                 135                 140                 


Gly Phe Leu Asp Asp Phe Phe Val Ile Phe Leu Leu Leu Ile Tyr Ile 
145                 150                 155                 160 


Ser Ile Met Tyr Arg Glu Val Ile Thr Gln Arg Leu Thr Arg 
                165                 170                 


<210>  1982
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  1982

Met Lys Ser Ile Leu Asp Gly Leu Ala Asp Thr Thr Phe Arg Thr Ile 
1               5                   10                  15      


Thr Thr Asp Leu Leu Tyr Val Gly Ser Asn Asp Ile Gln Tyr Glu Asp 
            20                  25                  30          


Ile Lys Gly Asp Met Ala Ser Lys Leu Gly Tyr Phe Pro Gln Lys Phe 
        35                  40                  45              


Pro Leu Thr Ser Phe Arg Gly Ser Pro Phe Gln Glu Lys Met Thr Ala 
    50                  55                  60                  


Gly Asp Asn Pro Gln Leu Val Pro Ala Asp Gln Val Asn Ile Thr Glu 
65                  70                  75                  80  


Phe Tyr Asn Lys Ser Leu Ser Ser Phe Lys Glu Asn Glu Glu Asn Ile 
                85                  90                  95      


Gln Cys Gly Glu Asn Phe Met Asp Ile Glu Cys Phe Met Val Leu Asn 
            100                 105                 110         


Pro Ser Gln Gln Leu Ala Ile Ala Val Leu Ser Leu Thr Leu Gly Thr 
        115                 120                 125             


Phe Thr Val Leu Glu Asn Leu Leu Val Leu Cys Val Ile Leu His Ser 
    130                 135                 140                 


Arg Ser Leu Arg Cys Arg Pro Ser Tyr His Phe Ile Gly Ser Leu Ala 
145                 150                 155                 160 


Val Ala Asp Leu Leu Gly Ser Val Ile Phe Val Tyr Ser Phe Ile Asp 
                165                 170                 175     


Phe His Val Phe His Arg Lys Asp Ser Arg Asn Val Phe Leu Phe Lys 
            180                 185                 190         


Leu Gly Gly Val Thr Ala Ser Phe Thr Ala Ser Val Gly Ser Leu Phe 
        195                 200                 205             


Leu Thr Ala Ile Asp Arg Tyr Ile Ser Ile His Arg Pro Leu Ala Tyr 
    210                 215                 220                 


Lys Arg Ile Val Thr Arg Pro Lys Ala Val Val Ala Phe Cys Leu Met 
225                 230                 235                 240 


Trp Thr Ile Ala Ile Val Ile Ala Val Leu Pro Leu Leu Gly Trp Asn 
                245                 250                 255     


Cys Glu Lys Leu Gln Ser Val Cys Ser Asp Ile Phe Pro His Ile Asp 
            260                 265                 270         


Glu Thr Tyr Leu Met Phe Trp Ile Gly Val Thr Ser Val Leu Leu Leu 
        275                 280                 285             


Phe Ile Val Tyr Ala Tyr Met Tyr Ile Leu Trp Lys Ala His Ser His 
    290                 295                 300                 


Ala Val Arg Met Ile Gln Arg Gly Thr Gln Lys Ser Ile Ile Ile His 
305                 310                 315                 320 


Thr Ser Glu Asp Gly Lys Val Gln Val Thr Arg Pro Asp Gln Ala Arg 
                325                 330                 335     


Met Asp Ile Arg Leu Ala Lys Thr Leu Val Leu Ile Leu Val Val Leu 
            340                 345                 350         


Ile Ile Cys Trp Gly Pro Leu Leu Ala Ile Met Val Tyr Asp Val Phe 
        355                 360                 365             


Gly Lys Met Asn Lys Leu Ile Lys Thr Val Phe Ala Phe Cys Ser Met 
    370                 375                 380                 


Leu Cys Leu Leu Asn Ser Thr Val Asn Pro Ile Ile Tyr Ala Leu Arg 
385                 390                 395                 400 


Ser Lys Asp Leu Arg His Ala Phe Arg Ser Met Phe Pro Ser Cys Glu 
                405                 410                 415     


Gly Thr Ala Gln Pro Leu Asp Asn Ser Met Gly Asp Ser Asp Cys Leu 
            420                 425                 430         


His Lys His Ala Asn Asn Ala Ala Ser Val His Arg Ala Ala Glu Ser 
        435                 440                 445             


Cys Ile Lys Ser Thr Val Lys Ile Ala Lys Val Thr Met Ser Val Ser 
    450                 455                 460                 


Thr Asp Thr Ser Ala Glu Ala Leu 
465                 470         


<210>  1983
<211>  1023
<212>  PRT
<213>  Homo sapiens

<400>  1983

Met Ala Phe Lys Val Gly Arg Asp Lys Tyr Glu Pro Ala Ala Val Ser 
1               5                   10                  15      


Glu Gln Gly Asp Lys Lys Gly Lys Lys Gly Lys Lys Asp Arg Asp Met 
            20                  25                  30          


Asp Glu Leu Lys Lys Glu Val Ser Met Asp Asp His Lys Leu Ser Leu 
        35                  40                  45              


Asp Glu Leu His Arg Lys Tyr Gly Thr Asp Leu Ser Arg Gly Leu Thr 
    50                  55                  60                  


Ser Ala Arg Ala Ala Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala Leu 
65                  70                  75                  80  


Thr Pro Pro Pro Thr Thr Pro Glu Trp Ile Lys Phe Cys Arg Gln Leu 
                85                  90                  95      


Phe Gly Gly Phe Ser Met Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe 
            100                 105                 110         


Leu Ala Tyr Ser Ile Gln Ala Ala Thr Glu Glu Glu Pro Gln Asn Asp 
        115                 120                 125             


Asn Leu Tyr Leu Gly Val Val Leu Ser Ala Val Val Ile Ile Thr Gly 
    130                 135                 140                 


Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Glu Ser 
145                 150                 155                 160 


Phe Lys Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Asn Gly Glu 
                165                 170                 175     


Lys Met Ser Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val Glu 
            180                 185                 190         


Val Lys Gly Gly Asp Arg Ile Pro Ala Asp Leu Arg Ile Ile Ser Ala 
        195                 200                 205             


Asn Gly Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro 
    210                 215                 220                 


Gln Thr Arg Ser Pro Asp Phe Thr Asn Glu Asn Pro Leu Glu Thr Arg 
225                 230                 235                 240 


Asn Ile Ala Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly 
                245                 250                 255     


Ile Val Val Tyr Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr 
            260                 265                 270         


Leu Ala Ser Gly Leu Glu Gly Gly Gln Thr Pro Ile Ala Ala Glu Ile 
        275                 280                 285             


Glu His Phe Ile His Ile Ile Thr Gly Val Ala Val Phe Leu Gly Val 
    290                 295                 300                 


Ser Phe Phe Ile Leu Ser Leu Ile Leu Glu Tyr Thr Trp Leu Glu Ala 
305                 310                 315                 320 


Val Ile Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu 
                325                 330                 335     


Leu Ala Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala 
            340                 345                 350         


Arg Lys Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly 
        355                 360                 365             


Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn 
    370                 375                 380                 


Arg Met Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala 
385                 390                 395                 400 


Asp Thr Thr Glu Asn Gln Ser Gly Val Ser Phe Asp Lys Thr Ser Ala 
                405                 410                 415     


Thr Trp Leu Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val 
            420                 425                 430         


Phe Gln Ala Asn Gln Glu Asn Leu Pro Ile Leu Lys Arg Ala Val Ala 
        435                 440                 445             


Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Cys Cys 
    450                 455                 460                 


Gly Ser Val Lys Glu Met Arg Glu Arg Tyr Ala Lys Ile Val Glu Ile 
465                 470                 475                 480 


Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Lys Asn Pro 
                485                 490                 495     


Asn Thr Ser Glu Pro Gln His Leu Leu Val Met Lys Gly Ala Pro Glu 
            500                 505                 510         


Arg Ile Leu Asp Arg Cys Ser Ser Ile Leu Leu His Gly Lys Glu Gln 
        515                 520                 525             


Pro Leu Asp Glu Glu Leu Lys Asp Ala Phe Gln Asn Ala Tyr Leu Glu 
    530                 535                 540                 


Leu Gly Gly Leu Gly Glu Arg Val Leu Gly Phe Cys His Leu Phe Leu 
545                 550                 555                 560 


Pro Asp Glu Gln Phe Pro Glu Gly Phe Gln Phe Asp Thr Asp Asp Val 
                565                 570                 575     


Asn Phe Pro Ile Asp Asn Leu Cys Phe Val Gly Leu Ile Ser Met Ile 
            580                 585                 590         


Asp Pro Pro Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser 
        595                 600                 605             


Ala Gly Ile Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala 
    610                 615                 620                 


Lys Ala Ile Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr 
625                 630                 635                 640 


Val Glu Asp Ile Ala Ala Arg Leu Asn Ile Pro Val Ser Gln Val Asn 
                645                 650                 655     


Pro Arg Asp Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp 
            660                 665                 670         


Met Thr Ser Glu Gln Leu Asp Asp Ile Leu Lys Tyr His Thr Glu Ile 
        675                 680                 685             


Val Phe Ala Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly 
    690                 695                 700                 


Cys Gln Arg Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn 
705                 710                 715                 720 


Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile Gly Val Ala Met Gly Ile 
                725                 730                 735     


Ala Gly Ser Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp 
            740                 745                 750         


Asp Asn Phe Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile 
        755                 760                 765             


Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile 
    770                 775                 780                 


Pro Glu Ile Thr Pro Phe Leu Ile Phe Ile Ile Ala Asn Ile Pro Leu 
785                 790                 795                 800 


Pro Leu Gly Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met 
                805                 810                 815     


Val Pro Ala Ile Ser Leu Ala Tyr Glu Gln Ala Glu Ser Asp Ile Met 
            820                 825                 830         


Lys Arg Gln Pro Arg Asn Pro Lys Thr Asp Lys Leu Val Asn Glu Arg 
        835                 840                 845             


Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly 
    850                 855                 860                 


Gly Phe Phe Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu Pro 
865                 870                 875                 880 


Ile His Leu Leu Gly Leu Arg Val Asp Trp Asp Asp Arg Trp Ile Asn 
                885                 890                 895     


Asp Val Glu Asp Ser Tyr Gly Gln Gln Trp Thr Tyr Glu Gln Arg Lys 
            900                 905                 910         


Ile Val Glu Phe Thr Cys His Thr Ala Phe Phe Val Ser Ile Val Val 
        915                 920                 925             


Val Gln Trp Ala Asp Leu Val Ile Cys Lys Thr Arg Arg Asn Ser Val 
    930                 935                 940                 


Phe Gln Gln Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Phe Glu 
945                 950                 955                 960 


Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Val 
                965                 970                 975     


Ala Leu Arg Met Tyr Pro Leu Lys Pro Thr Trp Trp Phe Cys Ala Phe 
            980                 985                 990         


Pro Tyr Ser Leu Leu Ile Phe Val  Tyr Asp Glu Val Arg  Lys Leu Ile 
        995                 1000                 1005             


Ile Arg  Arg Arg Pro Gly Gly  Trp Val Glu Lys Glu  Thr Tyr Tyr 
    1010                 1015                 1020             


<210>  1984
<211>  992
<212>  PRT
<213>  Homo sapiens

<400>  1984

Met Asp Glu Leu Lys Lys Glu Val Ser Met Asp Asp His Lys Leu Ser 
1               5                   10                  15      


Leu Asp Glu Leu His Arg Lys Tyr Gly Thr Asp Leu Ser Arg Gly Leu 
            20                  25                  30          


Thr Ser Ala Arg Ala Ala Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala 
        35                  40                  45              


Leu Thr Pro Pro Pro Thr Thr Pro Glu Trp Ile Lys Phe Cys Arg Gln 
    50                  55                  60                  


Leu Phe Gly Gly Phe Ser Met Leu Leu Trp Ile Gly Ala Ile Leu Cys 
65                  70                  75                  80  


Phe Leu Ala Tyr Ser Ile Gln Ala Ala Thr Glu Glu Glu Pro Gln Asn 
                85                  90                  95      


Asp Asn Leu Tyr Leu Gly Val Val Leu Ser Ala Val Val Ile Ile Thr 
            100                 105                 110         


Gly Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Glu 
        115                 120                 125             


Ser Phe Lys Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Asn Gly 
    130                 135                 140                 


Glu Lys Met Ser Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val 
145                 150                 155                 160 


Glu Val Lys Gly Gly Asp Arg Ile Pro Ala Asp Leu Arg Ile Ile Ser 
                165                 170                 175     


Ala Asn Gly Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu 
            180                 185                 190         


Pro Gln Thr Arg Ser Pro Asp Phe Thr Asn Glu Asn Pro Leu Glu Thr 
        195                 200                 205             


Arg Asn Ile Ala Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg 
    210                 215                 220                 


Gly Ile Val Val Tyr Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala 
225                 230                 235                 240 


Thr Leu Ala Ser Gly Leu Glu Gly Gly Gln Thr Pro Ile Ala Ala Glu 
                245                 250                 255     


Ile Glu His Phe Ile His Ile Ile Thr Gly Val Ala Val Phe Leu Gly 
            260                 265                 270         


Val Ser Phe Phe Ile Leu Ser Leu Ile Leu Glu Tyr Thr Trp Leu Glu 
        275                 280                 285             


Ala Val Ile Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly 
    290                 295                 300                 


Leu Leu Ala Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met 
305                 310                 315                 320 


Ala Arg Lys Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu 
                325                 330                 335     


Gly Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln 
            340                 345                 350         


Asn Arg Met Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu 
        355                 360                 365             


Ala Asp Thr Thr Glu Asn Gln Ser Gly Val Ser Phe Asp Lys Thr Ser 
    370                 375                 380                 


Ala Thr Trp Leu Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala 
385                 390                 395                 400 


Val Phe Gln Ala Asn Gln Glu Asn Leu Pro Ile Leu Lys Arg Ala Val 
                405                 410                 415     


Ala Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Cys 
            420                 425                 430         


Cys Gly Ser Val Lys Glu Met Arg Glu Arg Tyr Ala Lys Ile Val Glu 
        435                 440                 445             


Ile Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Lys Asn 
    450                 455                 460                 


Pro Asn Thr Ser Glu Pro Gln His Leu Leu Val Met Lys Gly Ala Pro 
465                 470                 475                 480 


Glu Arg Ile Leu Asp Arg Cys Ser Ser Ile Leu Leu His Gly Lys Glu 
                485                 490                 495     


Gln Pro Leu Asp Glu Glu Leu Lys Asp Ala Phe Gln Asn Ala Tyr Leu 
            500                 505                 510         


Glu Leu Gly Gly Leu Gly Glu Arg Val Leu Gly Phe Cys His Leu Phe 
        515                 520                 525             


Leu Pro Asp Glu Gln Phe Pro Glu Gly Phe Gln Phe Asp Thr Asp Asp 
    530                 535                 540                 


Val Asn Phe Pro Ile Asp Asn Leu Cys Phe Val Gly Leu Ile Ser Met 
545                 550                 555                 560 


Ile Asp Pro Pro Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg 
                565                 570                 575     


Ser Ala Gly Ile Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr 
            580                 585                 590         


Ala Lys Ala Ile Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu 
        595                 600                 605             


Thr Val Glu Asp Ile Ala Ala Arg Leu Asn Ile Pro Val Ser Gln Val 
    610                 615                 620                 


Asn Pro Arg Asp Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys 
625                 630                 635                 640 


Asp Met Thr Ser Glu Gln Leu Asp Asp Ile Leu Lys Tyr His Thr Glu 
                645                 650                 655     


Ile Val Phe Ala Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu 
            660                 665                 670         


Gly Cys Gln Arg Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val 
        675                 680                 685             


Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile Gly Val Ala Met Gly 
    690                 695                 700                 


Ile Ala Gly Ser Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu 
705                 710                 715                 720 


Asp Asp Asn Phe Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu 
                725                 730                 735     


Ile Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn 
            740                 745                 750         


Ile Pro Glu Ile Thr Pro Phe Leu Ile Phe Ile Ile Ala Asn Ile Pro 
        755                 760                 765             


Leu Pro Leu Gly Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp 
    770                 775                 780                 


Met Val Pro Ala Ile Ser Leu Ala Tyr Glu Gln Ala Glu Ser Asp Ile 
785                 790                 795                 800 


Met Lys Arg Gln Pro Arg Asn Pro Lys Thr Asp Lys Leu Val Asn Glu 
                805                 810                 815     


Arg Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu 
            820                 825                 830         


Gly Gly Phe Phe Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu 
        835                 840                 845             


Pro Ile His Leu Leu Gly Leu Arg Val Asp Trp Asp Asp Arg Trp Ile 
    850                 855                 860                 


Asn Asp Val Glu Asp Ser Tyr Gly Gln Gln Trp Thr Tyr Glu Gln Arg 
865                 870                 875                 880 


Lys Ile Val Glu Phe Thr Cys His Thr Ala Phe Phe Val Ser Ile Val 
                885                 890                 895     


Val Val Gln Trp Ala Asp Leu Val Ile Cys Lys Thr Arg Arg Asn Ser 
            900                 905                 910         


Val Phe Gln Gln Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Phe 
        915                 920                 925             


Glu Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly 
    930                 935                 940                 


Val Ala Leu Arg Met Tyr Pro Leu Lys Pro Thr Trp Trp Phe Cys Ala 
945                 950                 955                 960 


Phe Pro Tyr Ser Leu Leu Ile Phe Val Tyr Asp Glu Val Arg Lys Leu 
                965                 970                 975     


Ile Ile Arg Arg Arg Pro Gly Gly Trp Val Glu Lys Glu Thr Tyr Tyr 
            980                 985                 990         


<210>  1985
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  1985

Met Lys Ser Ile Leu Asp Gly Leu Ala Asp Thr Thr Phe Arg Thr Ile 
1               5                   10                  15      


Thr Thr Asp Leu Leu Tyr Val Gly Ser Asn Asp Ile Gln Tyr Glu Asp 
            20                  25                  30          


Ile Lys Gly Asp Met Ala Ser Lys Leu Gly Tyr Phe Pro Gln Lys Phe 
        35                  40                  45              


Pro Leu Thr Ser Phe Arg Gly Ser Pro Phe Gln Glu Lys Met Thr Ala 
    50                  55                  60                  


Gly Asp Asn Pro Gln Leu Val Pro Ala Asp Gln Val Asn Ile Thr Glu 
65                  70                  75                  80  


Phe Tyr Asn Lys Ser Leu Ser Ser Phe Lys Glu Asn Glu Glu Asn Ile 
                85                  90                  95      


Gln Cys Gly Glu Asn Phe Met Asp Ile Glu Cys Phe Met Val Leu Asn 
            100                 105                 110         


Pro Ser Gln Gln Leu Ala Ile Ala Val Leu Ser Leu Thr Leu Gly Thr 
        115                 120                 125             


Phe Thr Val Leu Glu Asn Leu Leu Val Leu Cys Val Ile Leu His Ser 
    130                 135                 140                 


Arg Ser Leu Arg Cys Arg Pro Ser Tyr His Phe Ile Gly Ser Leu Ala 
145                 150                 155                 160 


Val Ala Asp Leu Leu Gly Ser Val Ile Phe Val Tyr Ser Phe Ile Asp 
                165                 170                 175     


Phe His Val Phe His Arg Lys Asp Ser Arg Asn Val Phe Leu Phe Lys 
            180                 185                 190         


Leu Gly Gly Val Thr Ala Ser Phe Thr Ala Ser Val Gly Ser Leu Phe 
        195                 200                 205             


Leu Thr Ala Ile Asp Arg Tyr Ile Ser Ile His Arg Pro Leu Ala Tyr 
    210                 215                 220                 


Lys Arg Ile Val Thr Arg Pro Lys Ala Val Val Ala Phe Cys Leu Met 
225                 230                 235                 240 


Trp Thr Ile Ala Ile Val Ile Ala Val Leu Pro Leu Leu Gly Trp Asn 
                245                 250                 255     


Cys Glu Lys Leu Gln Ser Val Cys Ser Asp Ile Phe Pro His Ile Asp 
            260                 265                 270         


Glu Thr Tyr Leu Met Phe Trp Ile Gly Val Thr Ser Val Leu Leu Leu 
        275                 280                 285             


Phe Ile Val Tyr Ala Tyr Met Tyr Ile Leu Trp Lys Ala His Ser His 
    290                 295                 300                 


Ala Val Arg Met Ile Gln Arg Gly Thr Gln Lys Ser Ile Ile Ile His 
305                 310                 315                 320 


Thr Ser Glu Asp Gly Lys Val Gln Val Thr Arg Pro Asp Gln Ala Arg 
                325                 330                 335     


Met Asp Ile Arg Leu Ala Lys Thr Leu Val Leu Ile Leu Val Val Leu 
            340                 345                 350         


Ile Ile Cys Trp Gly Pro Leu Leu Ala Ile Met Val Tyr Asp Val Phe 
        355                 360                 365             


Gly Lys Met Asn Lys Leu Ile Lys Thr Val Phe Ala Phe Cys Ser Met 
    370                 375                 380                 


Leu Cys Leu Leu Asn Ser Thr Val Asn Pro Ile Ile Tyr Ala Leu Arg 
385                 390                 395                 400 


Ser Lys Asp Leu Arg His Ala Phe Arg Ser Met Phe Pro Ser Cys Glu 
                405                 410                 415     


Gly Thr Ala Gln Pro Leu Asp Asn Ser Met Gly Asp Ser Asp Cys Leu 
            420                 425                 430         


His Lys His Ala Asn Asn Ala Ala Ser Val His Arg Ala Ala Glu Ser 
        435                 440                 445             


Cys Ile Lys Ser Thr Val Lys Ile Ala Lys Val Thr Met Ser Val Ser 
    450                 455                 460                 


Thr Asp Thr Ser Ala Glu Ala Leu 
465                 470         


<210>  1986
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  1986

Met Lys Ser Ile Leu Asp Gly Leu Ala Asp Thr Thr Phe Arg Thr Ile 
1               5                   10                  15      


Thr Thr Asp Leu Leu Tyr Val Gly Ser Asn Asp Ile Gln Tyr Glu Asp 
            20                  25                  30          


Ile Lys Gly Asp Met Ala Ser Lys Leu Gly Tyr Phe Pro Gln Lys Phe 
        35                  40                  45              


Pro Leu Thr Ser Phe Arg Gly Ser Pro Phe Gln Glu Lys Met Thr Ala 
    50                  55                  60                  


Gly Asp Asn Pro Gln Leu Val Pro Ala Asp Gln Val Asn Ile Thr Glu 
65                  70                  75                  80  


Phe Tyr Asn Lys Ser Leu Ser Ser Phe Lys Glu Asn Glu Glu Asn Ile 
                85                  90                  95      


Gln Cys Gly Glu Asn Phe Met Asp Ile Glu Cys Phe Met Val Leu Asn 
            100                 105                 110         


Pro Ser Gln Gln Leu Ala Ile Ala Val Leu Ser Leu Thr Leu Gly Thr 
        115                 120                 125             


Phe Thr Val Leu Glu Asn Leu Leu Val Leu Cys Val Ile Leu His Ser 
    130                 135                 140                 


Arg Ser Leu Arg Cys Arg Pro Ser Tyr His Phe Ile Gly Ser Leu Ala 
145                 150                 155                 160 


Val Ala Asp Leu Leu Gly Ser Val Ile Phe Val Tyr Ser Phe Ile Asp 
                165                 170                 175     


Phe His Val Phe His Arg Lys Asp Ser Arg Asn Val Phe Leu Phe Lys 
            180                 185                 190         


Leu Gly Gly Val Thr Ala Ser Phe Thr Ala Ser Val Gly Ser Leu Phe 
        195                 200                 205             


Leu Thr Ala Ile Asp Arg Tyr Ile Ser Ile His Arg Pro Leu Ala Tyr 
    210                 215                 220                 


Lys Arg Ile Val Thr Arg Pro Lys Ala Val Val Ala Phe Cys Leu Met 
225                 230                 235                 240 


Trp Thr Ile Ala Ile Val Ile Ala Val Leu Pro Leu Leu Gly Trp Asn 
                245                 250                 255     


Cys Glu Lys Leu Gln Ser Val Cys Ser Asp Ile Phe Pro His Ile Asp 
            260                 265                 270         


Glu Thr Tyr Leu Met Phe Trp Ile Gly Val Thr Ser Val Leu Leu Leu 
        275                 280                 285             


Phe Ile Val Tyr Ala Tyr Met Tyr Ile Leu Trp Lys Ala His Ser His 
    290                 295                 300                 


Ala Val Arg Met Ile Gln Arg Gly Thr Gln Lys Ser Ile Ile Ile His 
305                 310                 315                 320 


Thr Ser Glu Asp Gly Lys Val Gln Val Thr Arg Pro Asp Gln Ala Arg 
                325                 330                 335     


Met Asp Ile Arg Leu Ala Lys Thr Leu Val Leu Ile Leu Val Val Leu 
            340                 345                 350         


Ile Ile Cys Trp Gly Pro Leu Leu Ala Ile Met Val Tyr Asp Val Phe 
        355                 360                 365             


Gly Lys Met Asn Lys Leu Ile Lys Thr Val Phe Ala Phe Cys Ser Met 
    370                 375                 380                 


Leu Cys Leu Leu Asn Ser Thr Val Asn Pro Ile Ile Tyr Ala Leu Arg 
385                 390                 395                 400 


Ser Lys Asp Leu Arg His Ala Phe Arg Ser Met Phe Pro Ser Cys Glu 
                405                 410                 415     


Gly Thr Ala Gln Pro Leu Asp Asn Ser Met Gly Asp Ser Asp Cys Leu 
            420                 425                 430         


His Lys His Ala Asn Asn Ala Ala Ser Val His Arg Ala Ala Glu Ser 
        435                 440                 445             


Cys Ile Lys Ser Thr Val Lys Ile Ala Lys Val Thr Met Ser Val Ser 
    450                 455                 460                 


Thr Asp Thr Ser Ala Glu Ala Leu 
465                 470         


<210>  1987
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  1987

Met Lys Ser Ile Leu Asp Gly Leu Ala Asp Thr Thr Phe Arg Thr Ile 
1               5                   10                  15      


Thr Thr Asp Leu Leu Tyr Val Gly Ser Asn Asp Ile Gln Tyr Glu Asp 
            20                  25                  30          


Ile Lys Gly Asp Met Ala Ser Lys Leu Gly Tyr Phe Pro Gln Lys Phe 
        35                  40                  45              


Pro Leu Thr Ser Phe Arg Gly Ser Pro Phe Gln Glu Lys Met Thr Ala 
    50                  55                  60                  


Gly Asp Asn Pro Gln Leu Val Pro Ala Asp Gln Val Asn Ile Thr Glu 
65                  70                  75                  80  


Phe Tyr Asn Lys Ser Leu Ser Ser Phe Lys Glu Asn Glu Glu Asn Ile 
                85                  90                  95      


Gln Cys Gly Glu Asn Phe Met Asp Ile Glu Cys Phe Met Val Leu Asn 
            100                 105                 110         


Pro Ser Gln Gln Leu Ala Ile Ala Val Leu Ser Leu Thr Leu Gly Thr 
        115                 120                 125             


Phe Thr Val Leu Glu Asn Leu Leu Val Leu Cys Val Ile Leu His Ser 
    130                 135                 140                 


Arg Ser Leu Arg Cys Arg Pro Ser Tyr His Phe Ile Gly Ser Leu Ala 
145                 150                 155                 160 


Val Ala Asp Leu Leu Gly Ser Val Ile Phe Val Tyr Ser Phe Ile Asp 
                165                 170                 175     


Phe His Val Phe His Arg Lys Asp Ser Arg Asn Val Phe Leu Phe Lys 
            180                 185                 190         


Leu Gly Gly Val Thr Ala Ser Phe Thr Ala Ser Val Gly Ser Leu Phe 
        195                 200                 205             


Leu Thr Ala Ile Asp Arg Tyr Ile Ser Ile His Arg Pro Leu Ala Tyr 
    210                 215                 220                 


Lys Arg Ile Val Thr Arg Pro Lys Ala Val Val Ala Phe Cys Leu Met 
225                 230                 235                 240 


Trp Thr Ile Ala Ile Val Ile Ala Val Leu Pro Leu Leu Gly Trp Asn 
                245                 250                 255     


Cys Glu Lys Leu Gln Ser Val Cys Ser Asp Ile Phe Pro His Ile Asp 
            260                 265                 270         


Glu Thr Tyr Leu Met Phe Trp Ile Gly Val Thr Ser Val Leu Leu Leu 
        275                 280                 285             


Phe Ile Val Tyr Ala Tyr Met Tyr Ile Leu Trp Lys Ala His Ser His 
    290                 295                 300                 


Ala Val Arg Met Ile Gln Arg Gly Thr Gln Lys Ser Ile Ile Ile His 
305                 310                 315                 320 


Thr Ser Glu Asp Gly Lys Val Gln Val Thr Arg Pro Asp Gln Ala Arg 
                325                 330                 335     


Met Asp Ile Arg Leu Ala Lys Thr Leu Val Leu Ile Leu Val Val Leu 
            340                 345                 350         


Ile Ile Cys Trp Gly Pro Leu Leu Ala Ile Met Val Tyr Asp Val Phe 
        355                 360                 365             


Gly Lys Met Asn Lys Leu Ile Lys Thr Val Phe Ala Phe Cys Ser Met 
    370                 375                 380                 


Leu Cys Leu Leu Asn Ser Thr Val Asn Pro Ile Ile Tyr Ala Leu Arg 
385                 390                 395                 400 


Ser Lys Asp Leu Arg His Ala Phe Arg Ser Met Phe Pro Ser Cys Glu 
                405                 410                 415     


Gly Thr Ala Gln Pro Leu Asp Asn Ser Met Gly Asp Ser Asp Cys Leu 
            420                 425                 430         


His Lys His Ala Asn Asn Ala Ala Ser Val His Arg Ala Ala Glu Ser 
        435                 440                 445             


Cys Ile Lys Ser Thr Val Lys Ile Ala Lys Val Thr Met Ser Val Ser 
    450                 455                 460                 


Thr Asp Thr Ser Ala Glu Ala Leu 
465                 470         


<210>  1988
<211>  643
<212>  PRT
<213>  Homo sapiens

<400>  1988

Met His His Leu Leu Glu Gln Ser Ala Asp Met Ala Thr Ala Leu Leu 
1               5                   10                  15      


Ala Gly Glu Lys Leu Arg Glu Leu Ile Leu Pro Gly Ala Gln Asp Asp 
            20                  25                  30          


Lys Ala Gly Ala Leu Ala Ala Leu Leu Leu Gln Leu Lys Leu Glu Leu 
        35                  40                  45              


Pro Phe Asp Arg Val Val Thr Ile Gly Thr Val Leu Val Pro Ile Leu 
    50                  55                  60                  


Leu Val Thr Leu Val Phe Thr Lys Asn Phe Ala Glu Glu Pro Ile Tyr 
65                  70                  75                  80  


Cys Tyr Thr Pro His Asn Phe Thr Arg Asp Gln Ala Leu Tyr Ala Arg 
                85                  90                  95      


Gly Tyr Cys Trp Thr Glu Leu Arg Asp Ala Leu Pro Gly Val Asp Ala 
            100                 105                 110         


Ser Leu Trp Pro Ser Leu Phe Glu His Lys Phe Leu Pro Tyr Ala Leu 
        115                 120                 125             


Leu Ala Phe Ala Ala Ile Met Tyr Val Pro Ala Leu Gly Trp Glu Phe 
    130                 135                 140                 


Leu Ala Ser Thr Arg Leu Thr Ser Glu Leu Asn Phe Leu Leu Gln Glu 
145                 150                 155                 160 


Ile Asp Asn Cys Tyr His Arg Ala Ala Glu Gly Arg Ala Pro Lys Ile 
                165                 170                 175     


Glu Lys Gln Ile Gln Ser Lys Gly Pro Gly Ile Thr Glu Arg Glu Lys 
            180                 185                 190         


Arg Glu Ile Ile Glu Asn Ala Glu Lys Glu Lys Ser Pro Glu Gln Asn 
        195                 200                 205             


Leu Phe Glu Lys Tyr Leu Glu Arg Arg Gly Arg Ser Asn Phe Leu Ala 
    210                 215                 220                 


Lys Leu Tyr Leu Ala Arg His Val Leu Ile Leu Leu Leu Ser Ala Val 
225                 230                 235                 240 


Pro Ile Ser Tyr Leu Cys Thr Tyr Tyr Ala Thr Gln Lys Gln Asn Glu 
                245                 250                 255     


Phe Thr Cys Ala Leu Gly Ala Ser Pro Asp Gly Ala Ala Gly Ala Gly 
            260                 265                 270         


Pro Ala Val Arg Val Ser Cys Lys Leu Pro Ser Val Gln Leu Gln Arg 
        275                 280                 285             


Ile Ile Ala Gly Val Asp Ile Val Leu Leu Cys Val Met Asn Leu Ile 
    290                 295                 300                 


Ile Leu Val Asn Leu Ile His Leu Phe Ile Phe Arg Lys Ser Asn Phe 
305                 310                 315                 320 


Ile Phe Asp Lys Leu His Lys Val Gly Ile Lys Thr Arg Arg Gln Trp 
                325                 330                 335     


Arg Arg Ser Gln Phe Cys Asp Ile Asn Ile Leu Ala Met Phe Cys Asn 
            340                 345                 350         


Glu Asn Arg Asp His Ile Lys Ser Leu Asn Arg Leu Asp Phe Ile Thr 
        355                 360                 365             


Asn Glu Ser Asp Leu Met Tyr Asp Asn Val Val Arg Gln Leu Leu Ala 
    370                 375                 380                 


Ala Leu Ala Gln Ser Asn His Asp Ala Thr Pro Thr Val Arg Asp Ser 
385                 390                 395                 400 


Gly Val Gln Thr Val Asp Pro Ser Ala Asn Pro Ala Glu Pro Asp Gly 
                405                 410                 415     


Ala Ala Glu Pro Pro Val Val Lys Arg Pro Arg Lys Lys Met Lys Trp 
            420                 425                 430         


Ile Pro Thr Ser Asn Pro Leu Pro Gln Pro Phe Lys Glu Pro Leu Ala 
        435                 440                 445             


Ile Met Arg Val Glu Asn Ser Lys Ala Glu Lys Pro Lys Pro Ala Arg 
    450                 455                 460                 


Arg Lys Thr Ala Thr Asp Thr Leu Ile Ala Pro Leu Leu Asp Arg Ser 
465                 470                 475                 480 


Ala His His Tyr Lys Gly Gly Gly Gly Asp Pro Gly Pro Gly Pro Ala 
                485                 490                 495     


Pro Ala Pro Ala Pro Pro Pro Ala Pro Asp Lys Lys His Ala Arg His 
            500                 505                 510         


Phe Ser Leu Asp Val His Pro Tyr Ile Leu Gly Thr Lys Lys Ala Lys 
        515                 520                 525             


Ala Glu Ala Val Pro Ala Ala Leu Pro Ala Ser Arg Ser Gln Glu Gly 
    530                 535                 540                 


Gly Phe Leu Ser Gln Ala Glu Asp Cys Gly Leu Gly Leu Ala Pro Ala 
545                 550                 555                 560 


Pro Ile Lys Asp Ala Pro Leu Pro Glu Lys Glu Ile Pro Tyr Pro Thr 
                565                 570                 575     


Glu Pro Ala Arg Ala Gly Leu Pro Ser Gly Gly Pro Phe His Val Arg 
            580                 585                 590         


Ser Pro Pro Ala Ala Pro Ala Val Ala Pro Leu Thr Pro Ala Ser Leu 
        595                 600                 605             


Gly Lys Ala Glu Pro Leu Thr Ile Leu Ser Arg Asn Ala Thr His Pro 
    610                 615                 620                 


Leu Leu His Ile Asn Thr Leu Ser Ser Ser Pro Pro Ser Thr Ser Arg 
625                 630                 635                 640 


Glu Arg Ser 
            


<210>  1989
<211>  1189
<212>  PRT
<213>  Homo sapiens

<400>  1989

Met Ala Arg Gln Pro Pro Pro Pro Trp Val His Ala Ala Phe Leu Leu 
1               5                   10                  15      


Cys Leu Leu Ser Leu Gly Gly Ala Ile Glu Ile Pro Met Asp Leu Thr 
            20                  25                  30          


Gln Pro Pro Thr Ile Thr Lys Gln Ser Ala Lys Asp His Ile Val Asp 
        35                  40                  45              


Pro Arg Asp Asn Ile Leu Ile Glu Cys Glu Ala Lys Gly Asn Pro Ala 
    50                  55                  60                  


Pro Ser Phe His Trp Thr Arg Asn Ser Arg Phe Phe Asn Ile Ala Lys 
65                  70                  75                  80  


Asp Pro Arg Val Ser Met Arg Arg Arg Ser Gly Thr Leu Val Ile Asp 
                85                  90                  95      


Phe Arg Ser Gly Gly Arg Pro Glu Glu Tyr Glu Gly Glu Tyr Gln Cys 
            100                 105                 110         


Phe Ala Arg Asn Lys Phe Gly Thr Ala Leu Ser Asn Arg Ile Arg Leu 
        115                 120                 125             


Gln Val Ser Lys Ser Pro Leu Trp Pro Lys Glu Asn Leu Asp Pro Val 
    130                 135                 140                 


Val Val Gln Glu Gly Ala Pro Leu Thr Leu Gln Cys Asn Pro Pro Pro 
145                 150                 155                 160 


Gly Leu Pro Ser Pro Val Ile Phe Trp Met Ser Ser Ser Met Glu Pro 
                165                 170                 175     


Ile Thr Gln Asp Lys Arg Val Ser Gln Gly His Asn Gly Asp Leu Tyr 
            180                 185                 190         


Phe Ser Asn Val Met Leu Gln Asp Met Gln Thr Asp Tyr Ser Cys Asn 
        195                 200                 205             


Ala Arg Phe His Phe Thr His Thr Ile Gln Gln Lys Asn Pro Phe Thr 
    210                 215                 220                 


Leu Lys Val Leu Thr Asn His Pro Tyr Asn Asp Ser Ser Leu Arg Asn 
225                 230                 235                 240 


His Pro Asp Met Tyr Ser Ala Arg Gly Val Ala Glu Arg Thr Pro Ser 
                245                 250                 255     


Phe Met Tyr Pro Gln Gly Thr Ala Ser Ser Gln Met Val Leu Arg Gly 
            260                 265                 270         


Met Asp Leu Leu Leu Glu Cys Ile Ala Ser Gly Val Pro Thr Pro Asp 
        275                 280                 285             


Ile Ala Trp Tyr Lys Lys Gly Gly Asp Leu Pro Ser Asp Lys Ala Lys 
    290                 295                 300                 


Phe Glu Asn Phe Asn Lys Ala Leu Arg Ile Thr Asn Val Ser Glu Glu 
305                 310                 315                 320 


Asp Ser Gly Glu Tyr Phe Cys Leu Ala Ser Asn Lys Met Gly Ser Ile 
                325                 330                 335     


Arg His Thr Ile Ser Val Arg Val Lys Ala Ala Pro Tyr Trp Leu Asp 
            340                 345                 350         


Glu Pro Lys Asn Leu Ile Leu Ala Pro Gly Glu Asp Gly Arg Leu Val 
        355                 360                 365             


Cys Arg Ala Asn Gly Asn Pro Lys Pro Thr Val Gln Trp Met Val Asn 
    370                 375                 380                 


Gly Glu Pro Leu Gln Ser Ala Pro Pro Asn Pro Asn Arg Glu Val Ala 
385                 390                 395                 400 


Gly Asp Thr Ile Ile Phe Arg Asp Thr Gln Ile Ser Ser Arg Ala Val 
                405                 410                 415     


Tyr Gln Cys Asn Thr Ser Asn Glu His Gly Tyr Leu Leu Ala Asn Ala 
            420                 425                 430         


Phe Val Ser Val Leu Asp Val Pro Pro Arg Met Leu Ser Pro Arg Asn 
        435                 440                 445             


Gln Leu Ile Arg Val Ile Leu Tyr Asn Arg Thr Arg Leu Asp Cys Pro 
    450                 455                 460                 


Phe Phe Gly Ser Pro Ile Pro Thr Leu Arg Trp Phe Lys Asn Gly Gln 
465                 470                 475                 480 


Gly Ser Asn Leu Asp Gly Gly Asn Tyr His Val Tyr Glu Asn Gly Ser 
                485                 490                 495     


Leu Glu Ile Lys Met Ile Arg Lys Glu Asp Gln Gly Ile Tyr Thr Cys 
            500                 505                 510         


Val Ala Thr Asn Ile Leu Gly Lys Ala Glu Asn Gln Val Arg Leu Glu 
        515                 520                 525             


Val Lys Asp Pro Thr Arg Ile Tyr Arg Met Pro Glu Asp Gln Val Ala 
    530                 535                 540                 


Arg Arg Gly Thr Thr Val Gln Leu Glu Cys Arg Val Lys His Asp Pro 
545                 550                 555                 560 


Ser Leu Lys Leu Thr Val Ser Trp Leu Lys Asp Asp Glu Pro Leu Tyr 
                565                 570                 575     


Ile Gly Asn Arg Met Lys Lys Glu Asp Asp Ser Leu Thr Ile Phe Gly 
            580                 585                 590         


Val Ala Glu Arg Asp Gln Gly Ser Tyr Thr Cys Val Ala Ser Thr Glu 
        595                 600                 605             


Leu Asp Gln Asp Leu Ala Lys Ala Tyr Leu Thr Val Leu Ala Asp Gln 
    610                 615                 620                 


Ala Thr Pro Thr Asn Arg Leu Ala Ala Leu Pro Lys Gly Arg Pro Asp 
625                 630                 635                 640 


Arg Pro Arg Asp Leu Glu Leu Thr Asp Leu Ala Glu Arg Ser Val Arg 
                645                 650                 655     


Leu Thr Trp Ile Pro Gly Asp Ala Asn Asn Ser Pro Ile Thr Asp Tyr 
            660                 665                 670         


Val Val Gln Phe Glu Glu Asp Gln Phe Gln Pro Gly Val Trp His Asp 
        675                 680                 685             


His Ser Lys Tyr Pro Gly Ser Val Asn Ser Ala Val Leu Arg Leu Ser 
    690                 695                 700                 


Pro Tyr Val Asn Tyr Gln Phe Arg Val Ile Ala Ile Asn Glu Val Gly 
705                 710                 715                 720 


Ser Ser His Pro Ser Leu Pro Ser Glu Arg Tyr Arg Thr Ser Gly Ala 
                725                 730                 735     


Pro Pro Glu Ser Asn Pro Gly Asp Val Lys Gly Glu Gly Thr Arg Lys 
            740                 745                 750         


Asn Asn Met Glu Ile Thr Trp Thr Pro Met Asn Ala Thr Ser Ala Phe 
        755                 760                 765             


Gly Pro Asn Leu Arg Tyr Ile Val Lys Trp Arg Arg Arg Glu Thr Arg 
    770                 775                 780                 


Glu Ala Trp Asn Asn Val Thr Val Trp Gly Ser Arg Tyr Val Val Gly 
785                 790                 795                 800 


Gln Thr Pro Val Tyr Val Pro Tyr Glu Ile Arg Val Gln Ala Glu Asn 
                805                 810                 815     


Asp Phe Gly Lys Gly Pro Glu Pro Glu Ser Val Ile Gly Tyr Ser Gly 
            820                 825                 830         


Glu Asp Tyr Pro Arg Ala Ala Pro Thr Glu Val Lys Val Arg Val Met 
        835                 840                 845             


Asn Ser Thr Ala Ile Ser Leu Gln Trp Asn Arg Val Tyr Ser Asp Thr 
    850                 855                 860                 


Val Gln Gly Gln Leu Arg Glu Tyr Arg Ala Tyr Tyr Trp Arg Glu Ser 
865                 870                 875                 880 


Ser Leu Leu Lys Asn Leu Trp Val Ser Gln Lys Arg Gln Gln Ala Ser 
                885                 890                 895     


Phe Pro Gly Asp Arg Leu Arg Gly Val Val Ser Arg Leu Phe Pro Tyr 
            900                 905                 910         


Ser Asn Tyr Lys Leu Glu Met Val Val Val Asn Gly Arg Gly Asp Gly 
        915                 920                 925             


Pro Arg Ser Glu Thr Lys Glu Phe Thr Thr Pro Glu Gly Val Pro Ser 
    930                 935                 940                 


Ala Pro Arg Arg Phe Arg Val Arg Gln Pro Asn Leu Glu Thr Ile Asn 
945                 950                 955                 960 


Leu Glu Trp Asp His Pro Glu His Pro Asn Gly Ile Met Ile Gly Tyr 
                965                 970                 975     


Thr Leu Lys Tyr Val Ala Phe Asn Gly Thr Lys Val Gly Lys Gln Ile 
            980                 985                 990         


Val Glu Asn Phe Ser Pro Asn Gln  Thr Lys Phe Thr Val  Gln Arg Thr 
        995                 1000                 1005             


Asp Pro  Val Ser Arg Tyr Arg  Phe Thr Leu Ser Ala  Arg Thr Gln 
    1010                 1015                 1020             


Val Gly  Ser Gly Glu Ala Val  Thr Glu Glu Ser Pro  Ala Pro Pro 
    1025                 1030                 1035             


Asn Glu  Ala Thr Pro Thr Ala  Ala Tyr Thr Asn Asn  Gln Ala Asp 
    1040                 1045                 1050             


Ile Ala  Thr Gln Gly Trp Phe  Ile Gly Leu Met Cys  Ala Ile Ala 
    1055                 1060                 1065             


Leu Leu  Val Leu Ile Leu Leu  Ile Val Cys Phe Ile  Lys Arg Ser 
    1070                 1075                 1080             


Arg Gly  Gly Lys Tyr Pro Val  Arg Glu Lys Lys Asp  Val Pro Leu 
    1085                 1090                 1095             


Gly Pro  Glu Asp Pro Lys Glu  Glu Asp Gly Ser Phe  Asp Tyr Ser 
    1100                 1105                 1110             


Asp Glu  Asp Asn Lys Pro Leu  Gln Gly Ser Gln Thr  Ser Leu Asp 
    1115                 1120                 1125             


Gly Thr  Ile Lys Gln Gln Glu  Ser Asp Asp Ser Leu  Val Asp Tyr 
    1130                 1135                 1140             


Gly Glu  Gly Gly Glu Gly Gln  Phe Asn Glu Asp Gly  Ser Phe Ile 
    1145                 1150                 1155             


Gly Gln  Tyr Thr Val Lys Lys  Asp Lys Glu Glu Thr  Glu Gly Asn 
    1160                 1165                 1170             


Glu Ser  Ser Glu Ala Thr Ser  Pro Val Asn Ala Ile  Tyr Ser Leu 
    1175                 1180                 1185             


Ala 
    


<210>  1990
<211>  1174
<212>  PRT
<213>  Homo sapiens

<400>  1990

Met Ala Arg Gln Pro Pro Pro Pro Trp Val His Ala Ala Phe Leu Leu 
1               5                   10                  15      


Cys Leu Leu Ser Leu Gly Gly Ala Ile Glu Ile Pro Met Asp Leu Thr 
            20                  25                  30          


Gln Pro Pro Thr Ile Thr Lys Gln Ser Ala Lys Asp His Ile Val Asp 
        35                  40                  45              


Pro Arg Asp Asn Ile Leu Ile Glu Cys Glu Ala Lys Gly Asn Pro Ala 
    50                  55                  60                  


Pro Ser Phe His Trp Thr Arg Asn Ser Arg Phe Phe Asn Ile Ala Lys 
65                  70                  75                  80  


Asp Pro Arg Val Ser Met Arg Arg Arg Ser Gly Thr Leu Val Ile Asp 
                85                  90                  95      


Phe Arg Ser Gly Gly Arg Pro Glu Glu Tyr Glu Gly Glu Tyr Gln Cys 
            100                 105                 110         


Phe Ala Arg Asn Lys Phe Gly Thr Ala Leu Ser Asn Arg Ile Arg Leu 
        115                 120                 125             


Gln Val Ser Lys Ser Pro Leu Trp Pro Lys Glu Asn Leu Asp Pro Val 
    130                 135                 140                 


Val Val Gln Glu Gly Ala Pro Leu Thr Leu Gln Cys Asn Pro Pro Pro 
145                 150                 155                 160 


Gly Leu Pro Ser Pro Val Ile Phe Trp Met Ser Ser Ser Met Glu Pro 
                165                 170                 175     


Ile Thr Gln Asp Lys Arg Val Ser Gln Gly His Asn Gly Asp Leu Tyr 
            180                 185                 190         


Phe Ser Asn Val Met Leu Gln Asp Met Gln Thr Asp Tyr Ser Cys Asn 
        195                 200                 205             


Ala Arg Phe His Phe Thr His Thr Ile Gln Gln Lys Asn Pro Phe Thr 
    210                 215                 220                 


Leu Lys Val Leu Thr Asn His Pro Tyr Asn Asp Ser Ser Leu Arg Asn 
225                 230                 235                 240 


His Pro Asp Met Tyr Ser Ala Arg Gly Val Ala Glu Arg Thr Pro Ser 
                245                 250                 255     


Phe Met Tyr Pro Gln Gly Thr Ala Ser Ser Gln Met Val Leu Arg Gly 
            260                 265                 270         


Met Asp Leu Leu Leu Glu Cys Ile Ala Ser Gly Val Pro Thr Pro Asp 
        275                 280                 285             


Ile Ala Trp Tyr Lys Lys Gly Gly Asp Leu Pro Ser Asp Lys Ala Lys 
    290                 295                 300                 


Phe Glu Asn Phe Asn Lys Ala Leu Arg Ile Thr Asn Val Ser Glu Glu 
305                 310                 315                 320 


Asp Ser Gly Glu Tyr Phe Cys Leu Ala Ser Asn Lys Met Gly Ser Ile 
                325                 330                 335     


Arg His Thr Ile Ser Val Arg Val Lys Ala Ala Pro Tyr Trp Leu Asp 
            340                 345                 350         


Glu Pro Lys Asn Leu Ile Leu Ala Pro Gly Glu Asp Gly Arg Leu Val 
        355                 360                 365             


Cys Arg Ala Asn Gly Asn Pro Lys Pro Thr Val Gln Trp Met Val Asn 
    370                 375                 380                 


Gly Glu Pro Leu Gln Ser Ala Pro Pro Asn Pro Asn Arg Glu Val Ala 
385                 390                 395                 400 


Gly Asp Thr Ile Ile Phe Arg Asp Thr Gln Ile Ser Ser Arg Ala Val 
                405                 410                 415     


Tyr Gln Cys Asn Thr Ser Asn Glu His Gly Tyr Leu Leu Ala Asn Ala 
            420                 425                 430         


Phe Val Ser Val Leu Asp Val Pro Pro Arg Met Leu Ser Pro Arg Asn 
        435                 440                 445             


Gln Leu Ile Arg Val Ile Leu Tyr Asn Arg Thr Arg Leu Asp Cys Pro 
    450                 455                 460                 


Phe Phe Gly Ser Pro Ile Pro Thr Leu Arg Trp Phe Lys Asn Gly Gln 
465                 470                 475                 480 


Gly Ser Asn Leu Asp Gly Gly Asn Tyr His Val Tyr Glu Asn Gly Ser 
                485                 490                 495     


Leu Glu Ile Lys Met Ile Arg Lys Glu Asp Gln Gly Ile Tyr Thr Cys 
            500                 505                 510         


Val Ala Thr Asn Ile Leu Gly Lys Ala Glu Asn Gln Val Arg Leu Glu 
        515                 520                 525             


Val Lys Asp Pro Thr Arg Ile Tyr Arg Met Pro Glu Asp Gln Val Ala 
    530                 535                 540                 


Arg Arg Gly Thr Thr Val Gln Leu Glu Cys Arg Val Lys His Asp Pro 
545                 550                 555                 560 


Ser Leu Lys Leu Thr Val Ser Trp Leu Lys Asp Asp Glu Pro Leu Tyr 
                565                 570                 575     


Ile Gly Asn Arg Met Lys Lys Glu Asp Asp Ser Leu Thr Ile Phe Gly 
            580                 585                 590         


Val Ala Glu Arg Asp Gln Gly Ser Tyr Thr Cys Val Ala Ser Thr Glu 
        595                 600                 605             


Leu Asp Gln Asp Leu Ala Lys Ala Tyr Leu Thr Val Leu Gly Arg Pro 
    610                 615                 620                 


Asp Arg Pro Arg Asp Leu Glu Leu Thr Asp Leu Ala Glu Arg Ser Val 
625                 630                 635                 640 


Arg Leu Thr Trp Ile Pro Gly Asp Ala Asn Asn Ser Pro Ile Thr Asp 
                645                 650                 655     


Tyr Val Val Gln Phe Glu Glu Asp Gln Phe Gln Pro Gly Val Trp His 
            660                 665                 670         


Asp His Ser Lys Tyr Pro Gly Ser Val Asn Ser Ala Val Leu Arg Leu 
        675                 680                 685             


Ser Pro Tyr Val Asn Tyr Gln Phe Arg Val Ile Ala Ile Asn Glu Val 
    690                 695                 700                 


Gly Ser Ser His Pro Ser Leu Pro Ser Glu Arg Tyr Arg Thr Ser Gly 
705                 710                 715                 720 


Ala Pro Pro Glu Ser Asn Pro Gly Asp Val Lys Gly Glu Gly Thr Arg 
                725                 730                 735     


Lys Asn Asn Met Glu Ile Thr Trp Thr Pro Met Asn Ala Thr Ser Ala 
            740                 745                 750         


Phe Gly Pro Asn Leu Arg Tyr Ile Val Lys Trp Arg Arg Arg Glu Thr 
        755                 760                 765             


Arg Glu Ala Trp Asn Asn Val Thr Val Trp Gly Ser Arg Tyr Val Val 
    770                 775                 780                 


Gly Gln Thr Pro Val Tyr Val Pro Tyr Glu Ile Arg Val Gln Ala Glu 
785                 790                 795                 800 


Asn Asp Phe Gly Lys Gly Pro Glu Pro Glu Ser Val Ile Gly Tyr Ser 
                805                 810                 815     


Gly Glu Asp Tyr Pro Arg Ala Ala Pro Thr Glu Val Lys Val Arg Val 
            820                 825                 830         


Met Asn Ser Thr Ala Ile Ser Leu Gln Trp Asn Arg Val Tyr Ser Asp 
        835                 840                 845             


Thr Val Gln Gly Gln Leu Arg Glu Tyr Arg Ala Tyr Tyr Trp Arg Glu 
    850                 855                 860                 


Ser Ser Leu Leu Lys Asn Leu Trp Val Ser Gln Lys Arg Gln Gln Ala 
865                 870                 875                 880 


Ser Phe Pro Gly Asp Arg Leu Arg Gly Val Val Ser Arg Leu Phe Pro 
                885                 890                 895     


Tyr Ser Asn Tyr Lys Leu Glu Met Val Val Val Asn Gly Arg Gly Asp 
            900                 905                 910         


Gly Pro Arg Ser Glu Thr Lys Glu Phe Thr Thr Pro Glu Gly Val Pro 
        915                 920                 925             


Ser Ala Pro Arg Arg Phe Arg Val Arg Gln Pro Asn Leu Glu Thr Ile 
    930                 935                 940                 


Asn Leu Glu Trp Asp His Pro Glu His Pro Asn Gly Ile Met Ile Gly 
945                 950                 955                 960 


Tyr Thr Leu Lys Tyr Val Ala Phe Asn Gly Thr Lys Val Gly Lys Gln 
                965                 970                 975     


Ile Val Glu Asn Phe Ser Pro Asn Gln Thr Lys Phe Thr Val Gln Arg 
            980                 985                 990         


Thr Asp Pro Val Ser Arg Tyr Arg  Phe Thr Leu Ser Ala  Arg Thr Gln 
        995                 1000                 1005             


Val Gly  Ser Gly Glu Ala Val  Thr Glu Glu Ser Pro  Ala Pro Pro 
    1010                 1015                 1020             


Asn Glu  Ala Thr Pro Thr Ala  Ala Tyr Thr Asn Asn  Gln Ala Asp 
    1025                 1030                 1035             


Ile Ala  Thr Gln Gly Trp Phe  Ile Gly Leu Met Cys  Ala Ile Ala 
    1040                 1045                 1050             


Leu Leu  Val Leu Ile Leu Leu  Ile Val Cys Phe Ile  Lys Arg Ser 
    1055                 1060                 1065             


Arg Gly  Gly Lys Tyr Pro Val  Arg Glu Lys Lys Asp  Val Pro Leu 
    1070                 1075                 1080             


Gly Pro  Glu Asp Pro Lys Glu  Glu Asp Gly Ser Phe  Asp Tyr Ser 
    1085                 1090                 1095             


Asp Glu  Asp Asn Lys Pro Leu  Gln Gly Ser Gln Thr  Ser Leu Asp 
    1100                 1105                 1110             


Gly Thr  Ile Lys Gln Gln Glu  Ser Asp Asp Ser Leu  Val Asp Tyr 
    1115                 1120                 1125             


Gly Glu  Gly Gly Glu Gly Gln  Phe Asn Glu Asp Gly  Ser Phe Ile 
    1130                 1135                 1140             


Gly Gln  Tyr Thr Val Lys Lys  Asp Lys Glu Glu Thr  Glu Gly Asn 
    1145                 1150                 1155             


Glu Ser  Ser Glu Ala Thr Ser  Pro Val Asn Ala Ile  Tyr Ser Leu 
    1160                 1165                 1170             


Ala 
    


<210>  1991
<211>  613
<212>  PRT
<213>  Homo sapiens

<400>  1991

Met Ala Arg Gln Pro Pro Pro Pro Trp Val His Ala Ala Phe Leu Leu 
1               5                   10                  15      


Cys Leu Leu Ser Leu Gly Gly Ala Ile Glu Ile Pro Met Asp Leu Thr 
            20                  25                  30          


Gln Pro Pro Thr Ile Thr Lys Gln Ser Ala Lys Asp His Ile Val Asp 
        35                  40                  45              


Pro Arg Asp Asn Ile Leu Ile Glu Cys Glu Ala Lys Gly Asn Pro Ala 
    50                  55                  60                  


Pro Ser Phe His Trp Thr Arg Asn Ser Arg Phe Phe Asn Ile Ala Lys 
65                  70                  75                  80  


Asp Pro Arg Val Ser Met Arg Arg Arg Ser Gly Thr Leu Val Ile Asp 
                85                  90                  95      


Phe Arg Ser Gly Gly Arg Pro Glu Glu Tyr Glu Gly Glu Tyr Gln Cys 
            100                 105                 110         


Phe Ala Arg Asn Lys Phe Gly Thr Ala Leu Ser Asn Arg Ile Arg Leu 
        115                 120                 125             


Gln Val Ser Lys Ser Pro Leu Trp Pro Lys Glu Asn Leu Asp Pro Val 
    130                 135                 140                 


Val Val Gln Glu Gly Ala Pro Leu Thr Leu Gln Cys Asn Pro Pro Pro 
145                 150                 155                 160 


Gly Leu Pro Ser Pro Val Ile Phe Trp Met Ser Ser Ser Met Glu Pro 
                165                 170                 175     


Ile Thr Gln Asp Lys Arg Val Ser Gln Gly His Asn Gly Asp Leu Tyr 
            180                 185                 190         


Phe Ser Asn Val Met Leu Gln Asp Met Gln Thr Asp Tyr Ser Cys Asn 
        195                 200                 205             


Ala Arg Phe His Phe Thr His Thr Ile Gln Gln Lys Asn Pro Phe Thr 
    210                 215                 220                 


Leu Lys Val Leu Thr Thr Arg Gly Val Ala Glu Arg Thr Pro Ser Phe 
225                 230                 235                 240 


Met Tyr Pro Gln Gly Thr Ala Ser Ser Gln Met Val Leu Arg Gly Met 
                245                 250                 255     


Asp Leu Leu Leu Glu Cys Ile Ala Ser Gly Val Pro Thr Pro Asp Ile 
            260                 265                 270         


Ala Trp Tyr Lys Lys Gly Gly Asp Leu Pro Ser Asp Lys Ala Lys Phe 
        275                 280                 285             


Glu Asn Phe Asn Lys Ala Leu Arg Ile Thr Asn Val Ser Glu Glu Asp 
    290                 295                 300                 


Ser Gly Glu Tyr Phe Cys Leu Ala Ser Asn Lys Met Gly Ser Ile Arg 
305                 310                 315                 320 


His Thr Ile Ser Val Arg Val Lys Ala Ala Pro Tyr Trp Leu Asp Glu 
                325                 330                 335     


Pro Lys Asn Leu Ile Leu Ala Pro Gly Glu Asp Gly Arg Leu Val Cys 
            340                 345                 350         


Arg Ala Asn Gly Asn Pro Lys Pro Thr Val Gln Trp Met Val Asn Gly 
        355                 360                 365             


Glu Pro Leu Gln Ser Ala Pro Pro Asn Pro Asn Arg Glu Val Ala Gly 
    370                 375                 380                 


Asp Thr Ile Ile Phe Arg Asp Thr Gln Ile Ser Ser Arg Ala Val Tyr 
385                 390                 395                 400 


Gln Cys Asn Thr Ser Asn Glu His Gly Tyr Leu Leu Ala Asn Ala Phe 
                405                 410                 415     


Val Ser Val Leu Asp Val Pro Pro Arg Met Leu Ser Pro Arg Asn Gln 
            420                 425                 430         


Leu Ile Arg Val Ile Leu Tyr Asn Arg Thr Arg Leu Asp Cys Pro Phe 
        435                 440                 445             


Phe Gly Ser Pro Ile Pro Thr Leu Arg Trp Phe Lys Asn Gly Gln Gly 
    450                 455                 460                 


Ser Asn Leu Asp Gly Gly Asn Tyr His Val Tyr Glu Asn Gly Ser Leu 
465                 470                 475                 480 


Glu Ile Lys Met Ile Arg Lys Glu Asp Gln Gly Ile Tyr Thr Cys Val 
                485                 490                 495     


Ala Thr Asn Ile Leu Gly Lys Ala Glu Asn Gln Val Arg Leu Glu Val 
            500                 505                 510         


Lys Asp Pro Thr Arg Ile Tyr Arg Met Pro Glu Asp Gln Val Ala Arg 
        515                 520                 525             


Arg Gly Thr Thr Val Gln Leu Glu Cys Arg Val Lys His Asp Pro Ser 
    530                 535                 540                 


Leu Lys Leu Thr Val Ser Trp Leu Lys Asp Asp Glu Pro Leu Tyr Ile 
545                 550                 555                 560 


Gly Asn Arg Met Lys Lys Glu Asp Asp Ser Leu Thr Ile Phe Gly Val 
                565                 570                 575     


Ala Glu Arg Asp Gln Gly Ser Tyr Thr Cys Val Ala Ser Thr Glu Leu 
            580                 585                 590         


Asp Gln Asp Leu Ala Lys Ala Tyr Leu Thr Val Leu Gly Asn Cys Pro 
        595                 600                 605             


Cys Ser Pro Trp His 
    610             


<210>  1992
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  1992

Met Ala Leu Leu Ala Leu Leu Leu Val Val Ala Leu Pro Arg Val Trp 
1               5                   10                  15      


Thr Asp Ala Asn Leu Thr Ala Arg Gln Arg Asp Pro Glu Asp Ser Gln 
            20                  25                  30          


Arg Thr Asp Glu Gly Asp Asn Arg Val Trp Cys His Val Cys Glu Arg 
        35                  40                  45              


Glu Asn Thr Phe Glu Cys Gln Asn Pro Arg Arg Cys Lys Trp Thr Glu 
    50                  55                  60                  


Pro Tyr Cys Val Ile Ala Ala Val Thr Thr Pro Arg Pro Ala Phe Pro 
65                  70                  75                  80  


Val His Met Asp Arg Pro Tyr His Ala Glu Ala Ser Pro Ser Leu Lys 
                85                  90                  95      


Gln His Ser Thr His Arg Pro Gly Pro Arg Pro Pro Asp Ser Pro Leu 
            100                 105                 110         


Val Pro Gln Leu Thr Val His Leu 
        115                 120 


<210>  1993
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  1993

Met Ala Leu Leu Ala Leu Leu Leu Val Val Ala Leu Pro Arg Val Trp 
1               5                   10                  15      


Thr Asp Ala Asn Leu Thr Ala Arg Gln Arg Asp Pro Glu Asp Ser Gln 
            20                  25                  30          


Arg Thr Asp Glu Gly Asp Asn Arg Val Trp Cys His Val Cys Glu Arg 
        35                  40                  45              


Glu Asn Thr Phe Glu Cys Gln Asn Pro Arg Arg Cys Lys Trp Thr Glu 
    50                  55                  60                  


Pro Tyr Cys Val Ile Ala Ala Val Thr Val Leu Arg Trp Leu Cys Ser 
65                  70                  75                  80  


Asp Gly Glu Thr Gln Ala Arg Gly Glu Ala Val Ser Pro Gly Arg Ala 
                85                  90                  95      


His Ala Leu Leu Leu Pro Gln Val Leu 
            100                 105 


<210>  1994
<211>  613
<212>  PRT
<213>  Homo sapiens

<400>  1994

Met Lys Tyr Leu Ser Glu Trp Asp Gln Trp Lys Arg Tyr Ser Ser Lys 
1               5                   10                  15      


Ser Trp Lys Arg Phe Leu Glu Lys Ala Arg Glu Met Thr Thr His Leu 
            20                  25                  30          


Glu Leu Trp Arg Glu Asp Ile Arg Ser Ile Glu Gly Lys Phe Gly Thr 
        35                  40                  45              


Gly Ile Gln Ser Tyr Phe Ser Phe Leu Arg Phe Leu Val Leu Leu Asn 
    50                  55                  60                  


Leu Val Ile Phe Leu Ile Ile Phe Met Leu Val Leu Leu Pro Val Leu 
65                  70                  75                  80  


Leu Thr Lys Tyr Lys Ile Thr Asn Ser Ser Phe Val Leu Ile Pro Phe 
                85                  90                  95      


Lys Asp Met Asp Lys Gln Cys Thr Val Tyr Pro Val Ser Ser Ser Gly 
            100                 105                 110         


Leu Ile Tyr Phe Tyr Ser Tyr Ile Ile Asp Leu Leu Ser Gly Thr Gly 
        115                 120                 125             


Phe Leu Glu Glu Thr Ser Leu Phe Tyr Gly His Tyr Thr Ile Asp Gly 
    130                 135                 140                 


Val Lys Phe Gln Asn Phe Thr Tyr Asp Leu Pro Leu Ala Tyr Leu Leu 
145                 150                 155                 160 


Ser Thr Ile Ala Ser Leu Ala Leu Ser Leu Leu Trp Ile Val Lys Arg 
                165                 170                 175     


Ser Val Glu Gly Phe Lys Ile Asn Leu Ile Arg Ser Glu Glu His Phe 
            180                 185                 190         


Gln Ser Tyr Cys Asn Lys Ile Phe Ala Gly Trp Asp Phe Cys Ile Thr 
        195                 200                 205             


Asn Arg Ser Met Ala Asp Leu Lys His Ser Ser Leu Arg Tyr Glu Leu 
    210                 215                 220                 


Arg Ala Asp Leu Glu Glu Glu Arg Met Arg Gln Lys Ile Ala Glu Arg 
225                 230                 235                 240 


Thr Ser Glu Glu Thr Ile Arg Ile Tyr Ser Leu Arg Leu Phe Leu Asn 
                245                 250                 255     


Cys Ile Val Leu Ala Val Leu Gly Ala Cys Phe Tyr Ala Ile Tyr Val 
            260                 265                 270         


Ala Thr Val Phe Ser Gln Glu His Met Lys Lys Glu Ile Asp Lys Met 
        275                 280                 285             


Val Phe Gly Glu Asn Leu Phe Ile Leu Tyr Leu Pro Ser Ile Val Ile 
    290                 295                 300                 


Thr Leu Ala Asn Phe Ile Thr Pro Met Ile Phe Ala Lys Ile Ile Arg 
305                 310                 315                 320 


Tyr Glu Asp Tyr Ser Pro Gly Phe Glu Ile Arg Leu Thr Ile Leu Arg 
                325                 330                 335     


Cys Val Phe Met Arg Leu Ala Thr Ile Cys Val Leu Val Phe Thr Leu 
            340                 345                 350         


Gly Ser Lys Ile Thr Ser Cys Asp Asp Asp Thr Cys Asp Leu Cys Gly 
        355                 360                 365             


Tyr Asn Gln Lys Leu Tyr Pro Cys Trp Glu Thr Gln Val Gly Gln Glu 
    370                 375                 380                 


Met Tyr Lys Leu Met Ile Phe Asp Phe Ile Ile Ile Leu Ala Val Thr 
385                 390                 395                 400 


Leu Phe Val Asp Phe Pro Arg Lys Leu Leu Val Thr Tyr Cys Ser Ser 
                405                 410                 415     


Cys Lys Leu Ile Gln Cys Trp Gly Gln Gln Glu Phe Ala Ile Pro Asp 
            420                 425                 430         


Asn Val Leu Gly Ile Val Tyr Gly Gln Thr Ile Cys Trp Ile Gly Ala 
        435                 440                 445             


Phe Phe Ser Pro Leu Leu Pro Ala Ile Ala Thr Leu Lys Phe Ile Ile 
    450                 455                 460                 


Ile Phe Tyr Val Lys Glu Trp Ser Leu Leu Tyr Thr Cys Arg Pro Ser 
465                 470                 475                 480 


Pro Arg Pro Phe Arg Ala Ser Asn Ser Asn Phe Phe Phe Leu Leu Val 
                485                 490                 495     


Leu Leu Ile Gly Leu Cys Leu Ala Ile Ile Pro Leu Thr Ile Ser Ile 
            500                 505                 510         


Ser Arg Ile Pro Ser Ser Lys Ala Cys Gly Pro Phe Thr Asn Phe Asn 
        515                 520                 525             


Thr Thr Trp Glu Val Ile Pro Lys Thr Val Ser Thr Phe Pro Ser Ser 
    530                 535                 540                 


Leu Gln Ser Phe Ile His Gly Val Thr Ser Glu Ala Phe Ala Val Pro 
545                 550                 555                 560 


Phe Phe Met Ile Ile Cys Leu Ile Met Phe Tyr Phe Ile Ala Leu Ala 
                565                 570                 575     


Gly Ala His Lys Arg Val Val Ile Gln Leu Arg Glu Gln Leu Ser Leu 
            580                 585                 590         


Glu Ser Arg Asp Lys Cys Tyr Leu Ile Gln Lys Leu Thr Glu Ala Gln 
        595                 600                 605             


Arg Asp Met Arg Asn 
    610             


<210>  1995
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  1995

Met Gly Tyr Ser Ala Val Pro Lys Cys Pro Pro Arg Gly Arg Gly Arg 
1               5                   10                  15      


Asp Ser Val Trp Gln Thr Pro Asp Met Leu Val Glu Ile Glu Thr Ala 
            20                  25                  30          


Trp Ser Leu Ser Gly Tyr Leu Leu Val Cys Phe Ser Ala Gly Tyr Phe 
        35                  40                  45              


Ile His Asp Thr Val Asp Ile Val Ala Ser Gly Gln Thr Arg Ala Ser 
    50                  55                  60                  


Trp Glu Tyr Leu Val His His Val Met Ala Met Gly Ala Phe Phe Ser 
65                  70                  75                  80  


Gly Ile Phe Trp Ser Ser Phe Val Gly Gly Gly Val Leu Thr Leu Leu 
                85                  90                  95      


Val Glu Val Ser Asn Ile Phe Leu Thr Ile Arg Met Met Met Lys Ile 
            100                 105                 110         


Ser Asn Ala Gln Asp His Leu Leu Tyr Arg Val Asn Lys Tyr Val Asn 
        115                 120                 125             


Leu Val Met Tyr Phe Leu Phe Arg Leu Ala Pro Gln Ala Tyr Leu Thr 
    130                 135                 140                 


His Phe Phe Leu Arg Tyr Val Asn Gln Arg Thr Leu Gly Thr Phe Leu 
145                 150                 155                 160 


Leu Gly Ile Leu Leu Met Leu Asp Val Met Ile Ile Ile Tyr Phe Ser 
                165                 170                 175     


Arg Leu Leu Arg Ser Asp Phe Cys Pro Glu His Val Pro Lys Lys Gln 
            180                 185                 190         


His Lys Asp Lys Phe Leu Thr Glu 
        195                 200 


<210>  1996
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  1996

Met Gly Gly Pro Arg Gly Ala Gly Trp Val Ala Ala Gly Leu Leu Leu 
1               5                   10                  15      


Gly Ala Gly Ala Cys Tyr Cys Ile Tyr Arg Leu Thr Arg Gly Arg Arg 
            20                  25                  30          


Arg Gly Asp Arg Glu Leu Gly Ile Arg Ser Ser Lys Ser Ala Glu Asp 
        35                  40                  45              


Leu Thr Asp Gly Ser Tyr Asp Asp Val Leu Asn Ala Glu Gln Leu Gln 
    50                  55                  60                  


Lys Leu Leu Tyr Leu Leu Glu Ser Thr Glu Asp Pro Val Ile Ile Glu 
65                  70                  75                  80  


Arg Ala Leu Ile Thr Leu Gly Asn Asn Ala Ala Phe Ser Val Asn Gln 
                85                  90                  95      


Ala Ile Ile Arg Glu Leu Gly Gly Ile Pro Ile Val Ala Asn Lys Ile 
            100                 105                 110         


Asn His Ser Asn Gln Ser Ile Lys Glu Lys Ala Leu Asn Ala Leu Asn 
        115                 120                 125             


Asn Leu Ser Val Asn Val Glu Asn Gln Ile Lys Ile Lys Ile Tyr Ile 
    130                 135                 140                 


Ser Gln Val Cys Glu Asp Val Phe Ser Gly Pro Leu Asn Ser Ala Val 
145                 150                 155                 160 


Gln Leu Ala Gly Leu Thr Leu Leu Thr Asn Met Thr Val Thr Asn Asp 
                165                 170                 175     


His Gln His Met Leu His Ser Tyr Ile Thr Asp Leu Phe Gln Val Leu 
            180                 185                 190         


Leu Thr Gly Asn Gly Asn Thr Lys Val Gln Val Leu Lys Leu Leu Leu 
        195                 200                 205             


Asn Leu Ser Glu Asn Pro Ala Met Thr Glu Gly Leu Leu Arg Ala Gln 
    210                 215                 220                 


Val Asp Ser Ser Phe Leu Ser Leu Tyr Asp Ser His Val Ala Lys Glu 
225                 230                 235                 240 


Ile Leu Leu Arg Val Leu Thr Leu Phe Gln Asn Ile Lys Asn Cys Leu 
                245                 250                 255     


Lys Ile Glu Gly His Leu Ala Val Gln Pro Thr Phe Thr Glu Gly Ser 
            260                 265                 270         


Leu Phe Phe Leu Leu His Gly Glu Glu Cys Ala Gln Lys Ile Arg Ala 
        275                 280                 285             


Leu Val Asp His His Asp Ala Glu Val Lys Glu Lys Val Val Thr Ile 
    290                 295                 300                 


Ile Pro Lys Ile 
305             


<210>  1997
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  1997

Met Gly Gly Pro Arg Gly Ala Gly Trp Val Ala Ala Gly Leu Leu Leu 
1               5                   10                  15      


Gly Ala Gly Ala Cys Tyr Cys Ile Tyr Arg Leu Thr Arg Gly Arg Arg 
            20                  25                  30          


Arg Gly Asp Arg Glu Leu Gly Ile Arg Ser Ser Lys Ser Ala Gly Ala 
        35                  40                  45              


Leu Glu Glu Gly Thr Ser Glu Gly Gln Leu Cys Gly Arg Ser Ala Arg 
    50                  55                  60                  


Pro Gln Thr Gly Gly Thr Trp Glu Ser Gln Trp Ser Lys Thr Ser Gln 
65                  70                  75                  80  


Pro Glu Asp Leu Thr Asp Gly Ser Tyr Asp Asp Val Leu Asn Ala Glu 
                85                  90                  95      


Gln Leu Gln Lys Leu Leu Tyr Leu Leu Glu Ser Thr Glu Asp Pro Val 
            100                 105                 110         


Ile Ile Glu Arg Ala Leu Ile Thr Leu Gly Asn Asn Ala Ala Phe Ser 
        115                 120                 125             


Val Asn Gln Ala Ile Ile Arg Glu Leu Gly Gly Ile Pro Ile Val Ala 
    130                 135                 140                 


Asn Lys Ile Asn His Ser Asn Gln Ser Ile Lys Glu Lys Ala Leu Asn 
145                 150                 155                 160 


Ala Leu Asn Asn Leu Ser Val Asn Val Glu Asn Gln Ile Lys Ile Lys 
                165                 170                 175     


Val Gln Val Leu Lys Leu Leu Leu Asn Leu Ser Glu Asn Pro Ala Met 
            180                 185                 190         


Thr Glu Gly Leu Leu Arg Ala Gln Val Asp Ser Ser Phe Leu Ser Leu 
        195                 200                 205             


Tyr Asp Ser His Val Ala Lys Glu Ile Leu Leu Arg Val Leu Thr Leu 
    210                 215                 220                 


Phe Gln Asn Ile Lys Asn Cys Leu Lys Ile Glu Gly His Leu Ala Val 
225                 230                 235                 240 


Gln Pro Thr Phe Thr Glu Gly Ser Leu Phe Phe Leu Leu His Gly Glu 
                245                 250                 255     


Glu Cys Ala Gln Lys Ile Arg Ala Leu Val Asp His His Asp Ala Glu 
            260                 265                 270         


Val Lys Glu Lys Val Val Thr Ile Ile Pro Lys Ile 
        275                 280                 


<210>  1998
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  1998

Met Gly Gly Pro Arg Gly Ala Gly Trp Val Ala Ala Gly Leu Leu Leu 
1               5                   10                  15      


Gly Ala Gly Ala Cys Tyr Cys Ile Tyr Arg Leu Thr Arg Gly Arg Arg 
            20                  25                  30          


Arg Gly Asp Arg Glu Leu Gly Ile Arg Ser Ser Lys Ser Ala Glu Asp 
        35                  40                  45              


Leu Thr Asp Gly Ser Tyr Asp Asp Val Leu Asn Ala Glu Gln Leu Gln 
    50                  55                  60                  


Lys Leu Leu Tyr Leu Leu Glu Ser Thr Glu Asp Pro Val Ile Ile Glu 
65                  70                  75                  80  


Arg Ala Leu Ile Thr Leu Gly Asn Asn Ala Ala Phe Ser Val Asn Gln 
                85                  90                  95      


Ala Ile Ile Arg Glu Leu Gly Gly Ile Pro Ile Val Ala Asn Lys Ile 
            100                 105                 110         


Asn His Ser Asn Gln Ser Ile Lys Glu Lys Ala Leu Asn Ala Leu Asn 
        115                 120                 125             


Asn Leu Ser Val Asn Val Glu Asn Gln Ile Lys Ile Lys Ile Tyr Ile 
    130                 135                 140                 


Ser Gln Val Cys Glu Asp Val Phe Ser Gly Pro Leu Asn Ser Ala Val 
145                 150                 155                 160 


Gln Leu Ala Gly Leu Thr Leu Leu Thr Asn Met Thr Val Thr Asn Asp 
                165                 170                 175     


His Gln His Met Leu His Ser Tyr Ile Thr Asp Leu Phe Gln Val Leu 
            180                 185                 190         


Leu Thr Gly Asn Gly Asn Thr Lys Val Asp Ser Ser Phe Leu Ser Leu 
        195                 200                 205             


Tyr Asp Ser His Val Ala Lys Glu Ile Leu Leu Arg Val Leu Thr Leu 
    210                 215                 220                 


Phe Gln Asn Ile Lys Asn Cys Leu Lys Ile Glu Gly His Leu Ala Val 
225                 230                 235                 240 


Gln Pro Thr Phe Thr Glu Gly Ser Leu Phe Phe Leu Leu His Gly Glu 
                245                 250                 255     


Glu Cys Ala Gln Lys Ile Arg Ala Leu Val Asp His His Asp Ala Glu 
            260                 265                 270         


Val Lys Glu Lys Val Val Thr Ile Ile Pro Lys Ile 
        275                 280                 


<210>  1999
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  1999

Met Gly Gly Pro Arg Gly Ala Gly Trp Val Ala Ala Gly Leu Leu Leu 
1               5                   10                  15      


Gly Ala Gly Ala Cys Tyr Cys Ile Tyr Arg Leu Thr Arg Gly Arg Arg 
            20                  25                  30          


Arg Gly Asp Arg Glu Leu Gly Ile Arg Ser Ser Lys Ser Ala Glu Asp 
        35                  40                  45              


Leu Thr Asp Gly Ser Tyr Asp Asp Val Leu Asn Ala Glu Gln Leu Gln 
    50                  55                  60                  


Lys Leu Leu Tyr Leu Leu Glu Ser Thr Glu Asp Pro Val Ile Ile Glu 
65                  70                  75                  80  


Arg Ala Leu Ile Thr Leu Gly Asn Asn Ala Ala Phe Ser Val Asn Gln 
                85                  90                  95      


Ala Ile Ile Arg Glu Leu Gly Gly Ile Pro Ile Val Ala Asn Lys Ile 
            100                 105                 110         


Asn His Ser Asn Gln Ser Ile Lys Glu Lys Ala Leu Asn Ala Leu Asn 
        115                 120                 125             


Asn Leu Ser Val Asn Val Glu Asn Gln Ile Lys Ile Lys Val Gln Val 
    130                 135                 140                 


Leu Lys Leu Leu Leu Asn Leu Ser Glu Asn Pro Ala Met Thr Glu Gly 
145                 150                 155                 160 


Leu Leu Arg Ala Gln Val Asp Ser Ser Phe Leu Ser Leu Tyr Asp Ser 
                165                 170                 175     


His Val Ala Lys Glu Ile Leu Leu Arg Val Leu Thr Leu Phe Gln Asn 
            180                 185                 190         


Ile Lys Asn Cys Leu Lys Ile Glu Gly His Leu Ala Val Gln Pro Thr 
        195                 200                 205             


Phe Thr Glu Gly Ser Leu Phe Phe Leu Leu His Gly Glu Glu Cys Ala 
    210                 215                 220                 


Gln Lys Ile Arg Ala Leu Val Asp His His Asp Ala Glu Val Lys Glu 
225                 230                 235                 240 


Lys Val Val Thr Ile Ile Pro Lys Ile 
                245                 


<210>  2000
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  2000

Met Gly Gly Pro Arg Gly Ala Gly Trp Val Ala Ala Gly Leu Leu Leu 
1               5                   10                  15      


Gly Ala Gly Ala Cys Tyr Cys Ile Tyr Arg Leu Thr Arg Gly Arg Arg 
            20                  25                  30          


Arg Gly Asp Arg Glu Leu Gly Ile Arg Ser Ser Lys Ser Ala Glu Asp 
        35                  40                  45              


Leu Thr Asp Gly Ser Tyr Asp Asp Val Leu Asn Ala Glu Gln Leu Gln 
    50                  55                  60                  


Lys Leu Leu Tyr Leu Leu Glu Ser Thr Glu Asp Pro Val Ile Ile Glu 
65                  70                  75                  80  


Arg Ala Leu Ile Thr Leu Gly Asn Asn Ala Ala Phe Ser Val Asn Gln 
                85                  90                  95      


Ala Ile Ile Arg Glu Leu Gly Gly Ile Pro Ile Val Ala Asn Lys Ile 
            100                 105                 110         


Asn His Ser Asn Gln Ser Ile Lys Glu Lys Ala Leu Asn Ala Leu Asn 
        115                 120                 125             


Asn Leu Ser Val Asn Val Glu Asn Gln Ile Lys Ile Lys Val Asp Ser 
    130                 135                 140                 


Ser Phe Leu Ser Leu Tyr Asp Ser His Val Ala Lys Glu Ile Leu Leu 
145                 150                 155                 160 


Arg Val Leu Thr Leu Phe Gln Asn Ile Lys Asn Cys Leu Lys Ile Glu 
                165                 170                 175     


Gly His Leu Ala Val Gln Pro Thr Phe Thr Glu Gly Ser Leu Phe Phe 
            180                 185                 190         


Leu Leu His Gly Glu Glu Cys Ala Gln Lys Ile Arg Ala Leu Val Asp 
        195                 200                 205             


His His Asp Ala Glu Val Lys Glu Lys Val Val Thr Ile Ile Pro Lys 
    210                 215                 220                 


Ile 
225 


<210>  2001
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  2001

Met Ser Pro Ala Ala Ala Ala Glu Pro Asp Gly Asp Gln Gln Asp Arg 
1               5                   10                  15      


His Val Ser Lys Leu Ile Phe Cys Phe Phe Val Phe Gly Ala Val Leu 
            20                  25                  30          


Leu Cys Val Gly Val Leu Leu Ser Ile Phe Gly Phe Gln Ala Cys Gln 
        35                  40                  45              


Tyr Lys Pro Leu Pro Asp Cys Pro Met Val Leu Lys Val Ala Gly Pro 
    50                  55                  60                  


Ala Cys Ala Val Val Gly Leu Gly Ala Val Ile Leu Ala Arg Ser Arg 
65                  70                  75                  80  


Ala Gln Leu Gln Leu Arg Ala Gly Leu Gln Arg Gly Gln Gln Met Asp 
                85                  90                  95      


Pro Asp Arg Ala Phe Ile Cys Gly Glu Ser Arg Gln Phe Ala Gln Cys 
            100                 105                 110         


Leu Ile Phe Gly Phe Leu Phe Leu Thr Ser Gly Met Leu Ile Ser Val 
        115                 120                 125             


Leu Gly Ile Trp Val Pro Gly Cys Gly Ser Asn Trp Ala Gln Glu Pro 
    130                 135                 140                 


Leu Asn Glu Thr Asp Thr Gly Asp Ser Glu Pro Arg Met Cys Gly Phe 
145                 150                 155                 160 


Leu Ser Leu Gln Ile Met Gly Pro Leu Ile Val Leu Val Gly Leu Cys 
                165                 170                 175     


Phe Phe Val Val Ala His Val Lys Lys Arg Asn Thr Leu Asn Ala Gly 
            180                 185                 190         


Gln Asp Ala Ser Glu Arg Glu Glu Gly Gln Ile Gln Ile Met Glu Pro 
        195                 200                 205             


Val Gln Val Thr Val Gly Asp Ser Val Ile Ile Phe Pro Pro Pro Pro 
    210                 215                 220                 


Pro Pro Tyr Phe Pro Glu Ser Ser Ala Ser Ala Val Ala Glu Ser Pro 
225                 230                 235                 240 


Gly Thr Asn Ser Leu Leu Pro Asn Glu Asn Pro Pro Ser Tyr Tyr Ser 
                245                 250                 255     


Ile Phe Asn Tyr Gly Thr Pro Thr Ser Glu Gly Ala Ala Ser Glu Arg 
            260                 265                 270         


Asp Cys Glu Ser Ile Tyr Thr Ile Ser Gly Thr Asn Ser Ser Ser Glu 
        275                 280                 285             


Ala Ser His Thr Pro His Leu Pro Ser Glu Leu Pro Pro Arg Tyr Glu 
    290                 295                 300                 


Glu Lys Glu Asn Ala Ala Ala Thr Phe Leu Pro Leu Ser Ser Glu Pro 
305                 310                 315                 320 


Ser Pro Pro 
            


<210>  2002
<211>  1236
<212>  PRT
<213>  Homo sapiens

<400>  2002

Met Ala Asn Gly Gly Gly Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Ser Ser Leu Arg Met Ser Ser Asn Ile His Ala Asn 
            20                  25                  30          


His Leu Ser Leu Asp Ala Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
        35                  40                  45              


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Val His Glu Pro 
    50                  55                  60                  


Lys Met Asp Ala Leu Ile Ile Pro Val Thr Met Glu Val Pro Cys Asp 
65                  70                  75                  80  


Ser Arg Gly Gln Arg Met Trp Trp Ala Phe Leu Ala Ser Ser Met Val 
                85                  90                  95      


Thr Phe Phe Gly Gly Leu Phe Ile Ile Leu Leu Trp Arg Thr Leu Lys 
            100                 105                 110         


Tyr Leu Trp Thr Val Cys Cys His Cys Gly Gly Lys Thr Lys Glu Ala 
        115                 120                 125             


Gln Lys Ile Asn Asn Gly Ser Ser Gln Ala Asp Gly Thr Leu Lys Pro 
    130                 135                 140                 


Val Asp Glu Lys Glu Glu Ala Val Ala Ala Glu Val Gly Trp Met Thr 
145                 150                 155                 160 


Ser Val Lys Asp Trp Ala Gly Val Met Ile Ser Ala Gln Thr Leu Thr 
                165                 170                 175     


Gly Arg Val Leu Val Val Leu Val Phe Ala Leu Ser Ile Gly Ala Leu 
            180                 185                 190         


Val Ile Tyr Phe Ile Asp Ser Ser Asn Pro Ile Glu Ser Cys Gln Asn 
        195                 200                 205             


Phe Tyr Lys Asp Phe Thr Leu Gln Ile Asp Met Ala Phe Asn Val Phe 
    210                 215                 220                 


Phe Leu Leu Tyr Phe Gly Leu Arg Phe Ile Ala Ala Asn Asp Lys Leu 
225                 230                 235                 240 


Trp Phe Trp Leu Glu Val Asn Ser Val Val Asp Phe Phe Thr Val Pro 
                245                 250                 255     


Pro Val Phe Val Ser Val Tyr Leu Asn Arg Ser Trp Leu Gly Leu Arg 
            260                 265                 270         


Phe Leu Arg Ala Leu Arg Leu Ile Gln Phe Ser Glu Ile Leu Gln Phe 
        275                 280                 285             


Leu Asn Ile Leu Lys Thr Ser Asn Ser Ile Lys Leu Val Asn Leu Leu 
    290                 295                 300                 


Ser Ile Phe Ile Ser Thr Trp Leu Thr Ala Ala Gly Phe Ile His Leu 
305                 310                 315                 320 


Val Glu Asn Ser Gly Asp Pro Trp Glu Asn Phe Gln Asn Asn Gln Ala 
                325                 330                 335     


Leu Thr Tyr Trp Glu Cys Val Tyr Leu Leu Met Val Thr Met Ser Thr 
            340                 345                 350         


Val Gly Tyr Gly Asp Val Tyr Ala Lys Thr Thr Leu Gly Arg Leu Phe 
        355                 360                 365             


Met Val Phe Phe Ile Leu Gly Gly Leu Ala Met Phe Ala Ser Tyr Val 
    370                 375                 380                 


Pro Glu Ile Ile Glu Leu Ile Gly Asn Arg Lys Lys Tyr Gly Gly Ser 
385                 390                 395                 400 


Tyr Ser Ala Val Ser Gly Arg Lys His Ile Val Val Cys Gly His Ile 
                405                 410                 415     


Thr Leu Glu Ser Val Ser Asn Phe Leu Lys Asp Phe Leu His Lys Asp 
            420                 425                 430         


Arg Asp Asp Val Asn Val Glu Ile Val Phe Leu His Asn Ile Ser Pro 
        435                 440                 445             


Asn Leu Glu Leu Glu Ala Leu Phe Lys Arg His Phe Thr Gln Val Glu 
    450                 455                 460                 


Phe Tyr Gln Gly Ser Val Leu Asn Pro His Asp Leu Ala Arg Val Lys 
465                 470                 475                 480 


Ile Glu Ser Ala Asp Ala Cys Leu Ile Leu Ala Asn Lys Tyr Cys Ala 
                485                 490                 495     


Asp Pro Asp Ala Glu Asp Ala Ser Asn Ile Met Arg Val Ile Ser Ile 
            500                 505                 510         


Lys Asn Tyr His Pro Lys Ile Arg Ile Ile Thr Gln Met Leu Gln Tyr 
        515                 520                 525             


His Asn Lys Ala His Leu Leu Asn Ile Pro Ser Trp Asn Trp Lys Glu 
    530                 535                 540                 


Gly Asp Asp Ala Ile Cys Leu Ala Glu Leu Lys Leu Gly Phe Ile Ala 
545                 550                 555                 560 


Gln Ser Cys Leu Ala Gln Gly Leu Ser Thr Met Leu Ala Asn Leu Phe 
                565                 570                 575     


Ser Met Arg Ser Phe Ile Lys Ile Glu Glu Asp Thr Trp Gln Lys Tyr 
            580                 585                 590         


Tyr Leu Glu Gly Val Ser Asn Glu Met Tyr Thr Glu Tyr Leu Ser Ser 
        595                 600                 605             


Ala Phe Val Gly Leu Ser Phe Pro Thr Val Cys Glu Leu Cys Phe Val 
    610                 615                 620                 


Lys Leu Lys Leu Leu Met Ile Ala Ile Glu Tyr Lys Ser Ala Asn Arg 
625                 630                 635                 640 


Glu Ser Arg Ile Leu Ile Asn Pro Gly Asn His Leu Lys Ile Gln Glu 
                645                 650                 655     


Gly Thr Leu Gly Phe Phe Ile Ala Ser Asp Ala Lys Glu Val Lys Arg 
            660                 665                 670         


Ala Phe Phe Tyr Cys Lys Ala Cys His Asp Asp Ile Thr Asp Pro Lys 
        675                 680                 685             


Arg Ile Lys Lys Cys Gly Cys Lys Arg Pro Lys Met Ser Ile Tyr Lys 
    690                 695                 700                 


Arg Met Arg Arg Ala Cys Cys Phe Asp Cys Gly Arg Ser Glu Arg Asp 
705                 710                 715                 720 


Cys Ser Cys Met Ser Gly Arg Val Arg Gly Asn Val Asp Thr Leu Glu 
                725                 730                 735     


Arg Ala Phe Pro Leu Ser Ser Val Ser Val Asn Asp Cys Ser Thr Ser 
            740                 745                 750         


Phe Arg Ala Phe Glu Asp Glu Gln Pro Ser Thr Leu Ser Pro Lys Lys 
        755                 760                 765             


Lys Gln Arg Asn Gly Gly Met Arg Asn Ser Pro Asn Thr Ser Pro Lys 
    770                 775                 780                 


Leu Met Arg His Asp Pro Leu Leu Ile Pro Gly Asn Asp Gln Ile Asp 
785                 790                 795                 800 


Asn Met Asp Ser Asn Val Lys Lys Tyr Asp Ser Thr Gly Met Phe His 
                805                 810                 815     


Trp Cys Ala Pro Lys Glu Ile Glu Lys Val Ile Leu Thr Arg Ser Glu 
            820                 825                 830         


Ala Ala Met Thr Val Leu Ser Gly His Val Val Val Cys Ile Phe Gly 
        835                 840                 845             


Asp Val Ser Ser Ala Leu Ile Gly Leu Arg Asn Leu Val Met Pro Leu 
    850                 855                 860                 


Arg Ala Ser Asn Phe His Tyr His Glu Leu Lys His Ile Val Phe Val 
865                 870                 875                 880 


Gly Ser Ile Glu Tyr Leu Lys Arg Glu Trp Glu Thr Leu His Asn Phe 
                885                 890                 895     


Pro Lys Val Ser Ile Leu Pro Gly Thr Pro Leu Ser Arg Ala Asp Leu 
            900                 905                 910         


Arg Ala Val Asn Ile Asn Leu Cys Asp Met Cys Val Ile Leu Ser Ala 
        915                 920                 925             


Asn Gln Asn Asn Ile Asp Asp Thr Ser Leu Gln Asp Lys Glu Cys Ile 
    930                 935                 940                 


Leu Ala Ser Leu Asn Ile Lys Ser Met Gln Phe Asp Asp Ser Ile Gly 
945                 950                 955                 960 


Val Leu Gln Ala Asn Ser Gln Gly Phe Thr Pro Pro Gly Met Asp Arg 
                965                 970                 975     


Ser Ser Pro Asp Asn Ser Pro Val His Gly Met Leu Arg Gln Pro Ser 
            980                 985                 990         


Ile Thr Thr Gly Val Asn Ile Pro  Ile Ile Thr Glu Leu  Val Asn Asp 
        995                 1000                 1005             


Thr Asn  Val Gln Phe Leu Asp  Gln Asp Asp Asp Asp  Asp Pro Asp 
    1010                 1015                 1020             


Thr Glu  Leu Tyr Leu Thr Gln  Pro Phe Ala Cys Gly  Thr Ala Phe 
    1025                 1030                 1035             


Ala Val  Ser Val Leu Asp Ser  Leu Met Ser Ala Thr  Tyr Phe Asn 
    1040                 1045                 1050             


Asp Asn  Ile Leu Thr Leu Ile  Arg Thr Leu Val Thr  Gly Gly Ala 
    1055                 1060                 1065             


Thr Pro  Glu Leu Glu Ala Leu  Ile Ala Glu Glu Asn  Ala Leu Arg 
    1070                 1075                 1080             


Gly Gly  Tyr Ser Thr Pro Gln  Thr Leu Ala Asn Arg  Asp Arg Cys 
    1085                 1090                 1095             


Arg Val  Ala Gln Leu Ala Leu  Leu Asp Gly Pro Phe  Ala Asp Leu 
    1100                 1105                 1110             


Gly Asp  Gly Gly Cys Tyr Gly  Asp Leu Phe Cys Lys  Ala Leu Lys 
    1115                 1120                 1125             


Thr Tyr  Asn Met Leu Cys Phe  Gly Ile Tyr Arg Leu  Arg Asp Ala 
    1130                 1135                 1140             


His Leu  Ser Thr Pro Ser Gln  Cys Thr Lys Arg Tyr  Val Ile Thr 
    1145                 1150                 1155             


Asn Pro  Pro Tyr Glu Phe Glu  Leu Val Pro Thr Asp  Leu Ile Phe 
    1160                 1165                 1170             


Cys Leu  Met Gln Phe Asp His  Asn Ala Gly Gln Ser  Arg Ala Ser 
    1175                 1180                 1185             


Leu Ser  His Ser Ser His Ser  Ser Gln Ser Ser Ser  Lys Lys Ser 
    1190                 1195                 1200             


Ser Ser  Val His Ser Ile Pro  Ser Thr Ala Asn Arg  Gln Asn Arg 
    1205                 1210                 1215             


Pro Lys  Ser Arg Glu Ser Arg  Asp Lys Gln Lys Tyr  Val Gln Glu 
    1220                 1225                 1230             


Glu Arg  Leu 
    1235     


<210>  2003
<211>  1219
<212>  PRT
<213>  Homo sapiens

<400>  2003

Met Ala Asn Gly Gly Gly Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Ser Ser Leu Arg Met Ser Ser Asn Ile His Ala Asn 
            20                  25                  30          


His Leu Ser Leu Asp Ala Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
        35                  40                  45              


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Val His Glu Pro 
    50                  55                  60                  


Lys Met Asp Ala Leu Ile Ile Pro Val Thr Met Glu Val Pro Cys Asp 
65                  70                  75                  80  


Ser Arg Gly Gln Arg Met Trp Trp Ala Phe Leu Ala Ser Ser Met Val 
                85                  90                  95      


Thr Phe Phe Gly Gly Leu Phe Ile Ile Leu Leu Trp Arg Thr Leu Lys 
            100                 105                 110         


Tyr Leu Trp Thr Val Cys Cys His Cys Gly Gly Lys Thr Lys Glu Ala 
        115                 120                 125             


Gln Lys Ile Asn Asn Gly Ser Ser Gln Ala Asp Gly Thr Leu Lys Pro 
    130                 135                 140                 


Val Asp Glu Lys Glu Glu Ala Val Ala Ala Glu Val Gly Trp Met Thr 
145                 150                 155                 160 


Ser Val Lys Asp Trp Ala Gly Val Met Ile Ser Ala Gln Thr Leu Thr 
                165                 170                 175     


Gly Arg Val Leu Val Val Leu Val Phe Ala Leu Ser Ile Gly Ala Leu 
            180                 185                 190         


Val Ile Tyr Phe Ile Asp Ser Ser Asn Pro Ile Glu Ser Cys Gln Asn 
        195                 200                 205             


Phe Tyr Lys Asp Phe Thr Leu Gln Ile Asp Met Ala Phe Asn Val Phe 
    210                 215                 220                 


Phe Leu Leu Tyr Phe Gly Leu Arg Phe Ile Ala Ala Asn Asp Lys Leu 
225                 230                 235                 240 


Trp Phe Trp Leu Glu Val Asn Ser Val Val Asp Phe Phe Thr Val Pro 
                245                 250                 255     


Pro Val Phe Val Ser Val Tyr Leu Asn Arg Ser Trp Leu Gly Leu Arg 
            260                 265                 270         


Phe Leu Arg Ala Leu Arg Leu Ile Gln Phe Ser Glu Ile Leu Gln Phe 
        275                 280                 285             


Leu Asn Ile Leu Lys Thr Ser Asn Ser Ile Lys Leu Val Asn Leu Leu 
    290                 295                 300                 


Ser Ile Phe Ile Ser Thr Trp Leu Thr Ala Ala Gly Phe Ile His Leu 
305                 310                 315                 320 


Val Glu Asn Ser Gly Asp Pro Trp Glu Asn Phe Gln Asn Asn Gln Ala 
                325                 330                 335     


Leu Thr Tyr Trp Glu Cys Val Tyr Leu Leu Met Val Thr Met Ser Thr 
            340                 345                 350         


Val Gly Tyr Gly Asp Val Tyr Ala Lys Thr Thr Leu Gly Arg Leu Phe 
        355                 360                 365             


Met Val Phe Phe Ile Leu Gly Gly Leu Ala Met Phe Ala Ser Tyr Val 
    370                 375                 380                 


Pro Glu Ile Ile Glu Leu Ile Gly Asn Arg Lys Lys Tyr Gly Gly Ser 
385                 390                 395                 400 


Tyr Ser Ala Val Ser Gly Arg Lys His Ile Val Val Cys Gly His Ile 
                405                 410                 415     


Thr Leu Glu Ser Val Ser Asn Phe Leu Lys Asp Phe Leu His Lys Asp 
            420                 425                 430         


Arg Asp Asp Val Asn Val Glu Ile Val Phe Leu His Asn Ile Ser Pro 
        435                 440                 445             


Asn Leu Glu Leu Glu Ala Leu Phe Lys Arg His Phe Thr Gln Val Glu 
    450                 455                 460                 


Phe Tyr Gln Gly Ser Val Leu Asn Pro His Asp Leu Ala Arg Val Lys 
465                 470                 475                 480 


Ile Glu Ser Ala Asp Ala Cys Leu Ile Leu Ala Asn Lys Tyr Cys Ala 
                485                 490                 495     


Asp Pro Asp Ala Glu Asp Ala Ser Asn Ile Met Arg Val Ile Ser Ile 
            500                 505                 510         


Lys Asn Tyr His Pro Lys Ile Arg Ile Ile Thr Gln Met Leu Gln Tyr 
        515                 520                 525             


His Asn Lys Ala His Leu Leu Asn Ile Pro Ser Trp Asn Trp Lys Glu 
    530                 535                 540                 


Gly Asp Asp Ala Ile Cys Leu Ala Glu Leu Lys Leu Gly Phe Ile Ala 
545                 550                 555                 560 


Gln Ser Cys Leu Ala Gln Gly Leu Ser Thr Met Leu Ala Asn Leu Phe 
                565                 570                 575     


Ser Met Arg Ser Phe Ile Lys Ile Glu Glu Asp Thr Trp Gln Lys Tyr 
            580                 585                 590         


Tyr Leu Glu Gly Val Ser Asn Glu Met Tyr Thr Glu Tyr Leu Ser Ser 
        595                 600                 605             


Ala Phe Val Gly Leu Ser Phe Pro Thr Val Cys Glu Leu Cys Phe Val 
    610                 615                 620                 


Lys Leu Lys Leu Leu Met Ile Ala Ile Glu Tyr Lys Ser Ala Asn Arg 
625                 630                 635                 640 


Glu Ser Arg Ile Leu Ile Asn Pro Gly Asn His Leu Lys Ile Gln Glu 
                645                 650                 655     


Gly Thr Leu Gly Phe Phe Ile Ala Ser Asp Ala Lys Glu Val Lys Arg 
            660                 665                 670         


Ala Phe Phe Tyr Cys Lys Ala Cys His Asp Asp Ile Thr Asp Pro Lys 
        675                 680                 685             


Arg Ile Lys Lys Cys Gly Cys Lys Arg Leu Glu Asp Glu Gln Pro Ser 
    690                 695                 700                 


Thr Leu Ser Pro Lys Lys Lys Gln Arg Asn Gly Gly Met Arg Asn Ser 
705                 710                 715                 720 


Pro Asn Thr Ser Pro Lys Leu Met Arg His Asp Pro Leu Leu Ile Pro 
                725                 730                 735     


Gly Asn Asp Gln Ile Asp Asn Met Asp Ser Asn Val Lys Lys Tyr Asp 
            740                 745                 750         


Ser Thr Gly Met Phe His Trp Cys Ala Pro Lys Glu Ile Glu Lys Val 
        755                 760                 765             


Ile Leu Val Thr Gly Trp Met Pro Tyr Leu Gly Pro Arg Val Leu Met 
    770                 775                 780                 


Thr Cys Leu Asp Ile Gly Val Val Cys Met Pro Thr Asp Ile Gln Ser 
785                 790                 795                 800 


Thr Ser Pro Ala Ser Ile Lys Lys Phe Lys Glu Thr Arg Ser Glu Ala 
                805                 810                 815     


Ala Met Thr Val Leu Ser Gly His Val Val Val Cys Ile Phe Gly Asp 
            820                 825                 830         


Val Ser Ser Ala Leu Ile Gly Leu Arg Asn Leu Val Met Pro Leu Arg 
        835                 840                 845             


Ala Ser Asn Phe His Tyr His Glu Leu Lys His Ile Val Phe Val Gly 
    850                 855                 860                 


Ser Ile Glu Tyr Leu Lys Arg Glu Trp Glu Thr Leu His Asn Phe Pro 
865                 870                 875                 880 


Lys Val Ser Ile Leu Pro Gly Thr Pro Leu Ser Arg Ala Asp Leu Arg 
                885                 890                 895     


Ala Val Asn Ile Asn Leu Cys Asp Met Cys Val Ile Leu Ser Ala Asn 
            900                 905                 910         


Gln Asn Asn Ile Asp Asp Thr Ser Leu Gln Asp Lys Glu Cys Ile Leu 
        915                 920                 925             


Ala Ser Leu Asn Ile Lys Ser Met Gln Phe Asp Asp Ser Ile Gly Val 
    930                 935                 940                 


Leu Gln Ala Asn Ser Gln Gly Phe Thr Pro Pro Gly Met Asp Arg Ser 
945                 950                 955                 960 


Ser Pro Asp Asn Ser Pro Val His Gly Met Leu Arg Gln Pro Ser Ile 
                965                 970                 975     


Thr Thr Gly Val Asn Ile Pro Ile Ile Thr Glu Leu Val Asn Asp Thr 
            980                 985                 990         


Asn Val Gln Phe Leu Asp Gln Asp  Asp Asp Asp Asp Pro  Asp Thr Glu 
        995                 1000                 1005             


Leu Tyr  Leu Thr Gln Pro Phe  Ala Cys Gly Thr Ala  Phe Ala Val 
    1010                 1015                 1020             


Ser Val  Leu Asp Ser Leu Met  Ser Ala Thr Tyr Phe  Asn Asp Asn 
    1025                 1030                 1035             


Ile Leu  Thr Leu Ile Arg Thr  Leu Val Thr Gly Gly  Ala Thr Pro 
    1040                 1045                 1050             


Glu Leu  Glu Ala Leu Ile Ala  Glu Glu Asn Ala Leu  Arg Gly Gly 
    1055                 1060                 1065             


Tyr Ser  Thr Pro Gln Thr Leu  Ala Asn Arg Asp Arg  Cys Arg Val 
    1070                 1075                 1080             


Ala Gln  Leu Ala Leu Leu Asp  Gly Pro Phe Ala Asp  Leu Gly Asp 
    1085                 1090                 1095             


Gly Gly  Cys Tyr Gly Asp Leu  Phe Cys Lys Ala Leu  Lys Thr Tyr 
    1100                 1105                 1110             


Asn Met  Leu Cys Phe Gly Ile  Tyr Arg Leu Arg Asp  Ala His Leu 
    1115                 1120                 1125             


Ser Thr  Pro Ser Gln Cys Thr  Lys Arg Tyr Val Ile  Thr Asn Pro 
    1130                 1135                 1140             


Pro Tyr  Glu Phe Glu Leu Val  Pro Thr Asp Leu Ile  Phe Cys Leu 
    1145                 1150                 1155             


Met Gln  Phe Asp His Asn Ala  Gly Gln Ser Arg Ala  Ser Leu Ser 
    1160                 1165                 1170             


His Ser  Ser His Ser Ser Gln  Ser Ser Ser Lys Lys  Ser Ser Ser 
    1175                 1180                 1185             


Val His  Ser Ile Pro Ser Thr  Ala Asn Arg Gln Asn  Arg Pro Lys 
    1190                 1195                 1200             


Ser Arg  Glu Ser Arg Asp Lys  Gln Lys Tyr Val Gln  Glu Glu Arg 
    1205                 1210                 1215             


Leu 
    


<210>  2004
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  2004

Met Ser Gly Ser Ser Leu Pro Ser Ala Leu Ala Leu Ser Leu Leu Leu 
1               5                   10                  15      


Val Ser Gly Ser Leu Leu Pro Gly Pro Gly Ala Ala Gln Asn Ala Gly 
            20                  25                  30          


Phe Val Lys Ser Pro Met Ser Glu Thr Lys Leu Thr Gly Asp Ala Phe 
        35                  40                  45              


Glu Leu Tyr Cys Asp Val Val Gly Ser Pro Thr Pro Glu Ile Gln Trp 
    50                  55                  60                  


Trp Tyr Ala Glu Val Asn Arg Ala Glu Ser Phe Arg Gln Leu Trp Asp 
65                  70                  75                  80  


Gly Ala Arg Lys Arg Arg Val Thr Val Asn Thr Ala Tyr Gly Ser Asn 
                85                  90                  95      


Gly Val Ser Val Leu Arg Ile Thr Arg Leu Thr Leu Glu Asp Ser Gly 
            100                 105                 110         


Thr Tyr Glu Cys Arg Ala Ser Asn Asp Pro Lys Arg Asn Asp Leu Arg 
        115                 120                 125             


Gln Asn Pro Ser Ile Thr Trp Ile Arg Ala Gln Ala Thr Ile Ser Val 
    130                 135                 140                 


Leu Gln Lys Pro Arg Ile Val Thr Ser Glu Glu Val Ile Ile Arg Asp 
145                 150                 155                 160 


Ser Pro Val Leu Pro Val Thr Leu Gln Cys Asn Leu Thr Ser Ser Ser 
                165                 170                 175     


His Thr Leu Thr Tyr Ser Tyr Trp Thr Lys Asn Gly Val Glu Leu Ser 
            180                 185                 190         


Ala Thr Arg Lys Asn Ala Ser Asn Met Glu Tyr Arg Ile Asn Lys Pro 
        195                 200                 205             


Arg Ala Glu Asp Ser Gly Glu Tyr His Cys Val Tyr His Phe Val Ser 
    210                 215                 220                 


Ala Pro Lys Ala Asn Ala Thr Ile Glu Val Lys Ala Ala Pro Asp Ile 
225                 230                 235                 240 


Thr Gly His Lys Arg Ser Glu Asn Lys Asn Glu Gly Gln Asp Ala Thr 
                245                 250                 255     


Met Tyr Cys Lys Ser Val Gly Tyr Pro His Pro Asp Trp Ile Trp Arg 
            260                 265                 270         


Lys Lys Glu Asn Gly Met Pro Met Asp Ile Val Asn Thr Ser Gly Arg 
        275                 280                 285             


Phe Phe Ile Ile Asn Lys Glu Asn Tyr Thr Glu Leu Asn Ile Val Asn 
    290                 295                 300                 


Leu Gln Ile Thr Glu Asp Pro Gly Glu Tyr Glu Cys Asn Ala Thr Asn 
305                 310                 315                 320 


Ala Ile Gly Ser Ala Ser Val Val Thr Val Leu Arg Val Arg Ser His 
                325                 330                 335     


Leu Ala Pro Leu Trp Pro Phe Leu Gly Ile Leu Ala Glu Ile Ile Ile 
            340                 345                 350         


Leu Val Val Ile Ile Val Val Tyr Glu Lys Arg Lys Arg Pro Asp Glu 
        355                 360                 365             


Val Pro Asp Ala Gly Pro Met Lys Thr Asn Ser Thr Asn Asn His Lys 
    370                 375                 380                 


Asp Lys Asn Leu Arg Gln Arg Asn Thr Asn 
385                 390                 


<210>  2005
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  2005

Met Ser Gly Ser Ser Leu Pro Ser Ala Leu Ala Leu Ser Leu Leu Leu 
1               5                   10                  15      


Val Ser Gly Ser Leu Leu Pro Gly Pro Gly Ala Ala Gln Asn Glu Pro 
            20                  25                  30          


Arg Ile Val Thr Ser Glu Glu Val Ile Ile Arg Asp Ser Pro Val Leu 
        35                  40                  45              


Pro Val Thr Leu Gln Cys Asn Leu Thr Ser Ser Ser His Thr Leu Thr 
    50                  55                  60                  


Tyr Ser Tyr Trp Thr Lys Asn Gly Val Glu Leu Ser Ala Thr Arg Lys 
65                  70                  75                  80  


Asn Ala Ser Asn Met Glu Tyr Arg Ile Asn Lys Pro Arg Ala Glu Asp 
                85                  90                  95      


Ser Gly Glu Tyr His Cys Val Tyr His Phe Val Ser Ala Pro Lys Ala 
            100                 105                 110         


Asn Ala Thr Ile Glu Val Lys Ala Ala Pro Asp Ile Thr Gly His Lys 
        115                 120                 125             


Arg Ser Glu Asn Lys Asn Glu Gly Gln Asp Ala Thr Met Tyr Cys Lys 
    130                 135                 140                 


Ser Val Gly Tyr Pro His Pro Asp Trp Ile Trp Arg Lys Lys Glu Asn 
145                 150                 155                 160 


Gly Met Pro Met Asp Ile Val Asn Thr Ser Gly Arg Phe Phe Ile Ile 
                165                 170                 175     


Asn Lys Glu Asn Tyr Thr Glu Leu Asn Ile Val Asn Leu Gln Ile Thr 
            180                 185                 190         


Glu Asp Pro Gly Glu Tyr Glu Cys Asn Ala Thr Asn Ala Ile Gly Ser 
        195                 200                 205             


Ala Ser Val Val Thr Val Leu Arg Val Arg Ser His Leu Ala Pro Leu 
    210                 215                 220                 


Trp Pro Phe Leu Gly Ile Leu Ala Glu Ile Ile Ile Leu Val Val Ile 
225                 230                 235                 240 


Ile Val Val Tyr Glu Lys Arg Lys Arg Pro Asp Glu Val Pro Asp Ala 
                245                 250                 255     


Gly Pro Met Lys Thr Asn Ser Thr Asn Asn His Lys Asp Lys Asn Leu 
            260                 265                 270         


Arg Gln Arg Asn Thr Asn 
        275             


<210>  2006
<211>  496
<212>  PRT
<213>  Homo sapiens

<400>  2006

Met Tyr Gln Pro Ser Arg Gly Ala Ala Arg Arg Leu Gly Pro Cys Leu 
1               5                   10                  15      


Arg Ala Tyr Gln Ala Arg Pro Gln Val Ser Gly Gly Glu Glu Gly Gly 
            20                  25                  30          


Arg Arg Gly Gly Gly Glu Arg Pro Ser Ser Lys Pro Val Arg Gly Ala 
        35                  40                  45              


Glu Arg Ala Leu Gly Ser Ala Gln Ala Gln Arg His Pro Pro Pro Leu 
    50                  55                  60                  


Pro Thr Cys Ala Leu Gln Arg Val Asp Arg Leu Gly Val Ala Gly Ala 
65                  70                  75                  80  


Gly Gly Arg Arg Cys Arg Ala Cys Arg Ala Arg Thr Ser Val Leu Pro 
                85                  90                  95      


Gly Leu Arg Ala Val Arg Arg Gly Gln Gly Gln Ala Ala Gly Arg Val 
            100                 105                 110         


Cys Val Ala Pro Asp Ser Pro Arg Leu Pro Val Pro Arg Gly Asp Leu 
        115                 120                 125             


Lys Gly Arg Gly Arg Glu Ile Arg Ser Pro Ala Ala Ala Pro Ser Arg 
    130                 135                 140                 


Ser Ser Pro Ala Gln Thr Arg Pro Ala Gly Arg Pro Gln Gln Pro Ala 
145                 150                 155                 160 


Arg Leu Ala Leu Gly Glu Arg Ser Trp Gln Glu Gly Arg Pro Val Cys 
                165                 170                 175     


Thr Arg Phe Gly Pro Leu Arg Pro Gly Trp Gln Asp Gly His Ala Pro 
            180                 185                 190         


Ser Arg Asp Gly Ala Ser Arg Thr Pro Ser Gly Thr Glu Asp Gln Leu 
        195                 200                 205             


Tyr Pro Gly Thr Leu Pro Phe Pro Pro Leu Trp Pro His Ser Thr Thr 
    210                 215                 220                 


Thr Thr Ser Pro Ser Ser Pro Leu Phe Trp Ser Pro Leu Pro Pro Arg 
225                 230                 235                 240 


Leu Pro Thr Gln Arg Leu Pro Gln Val Pro Pro Leu Pro Leu Pro Gln 
                245                 250                 255     


Ile Gln Ala Leu Ser Ser Ala Trp Val Val Leu Pro Pro Gly Lys Gly 
            260                 265                 270         


Glu Glu Gly Pro Gly Pro Glu Leu His Ser Gly Cys Leu Asp Gly Leu 
        275                 280                 285             


Arg Ser Leu Phe Glu Gly Pro Pro Cys Pro Tyr Pro Gly Ala Trp Ile 
    290                 295                 300                 


Pro Phe Gln Val Pro Gly Thr Ala His Pro Ser Pro Ala Thr Pro Ser 
305                 310                 315                 320 


Gly Asp Pro Ser Met Glu Glu His Leu Ser Val Met Tyr Glu Arg Leu 
                325                 330                 335     


Arg Gln Glu Leu Pro Lys Leu Phe Leu Gln Ser His Asp Tyr Ser Leu 
            340                 345                 350         


Tyr Ser Leu Asp Val Glu Phe Ile Asn Glu Ile Leu Asn Ile Arg Thr 
        355                 360                 365             


Lys Gly Arg Thr Trp Tyr Ile Leu Ser Leu Thr Leu Cys Arg Phe Leu 
    370                 375                 380                 


Ala Trp Asn Tyr Phe Ala His Leu Arg Leu Glu Val Leu Gln Leu Thr 
385                 390                 395                 400 


Arg His Pro Glu Asn Trp Thr Leu Gln Ala Arg Trp Arg Leu Val Gly 
                405                 410                 415     


Leu Pro Val His Leu Leu Phe Leu Arg Phe Tyr Lys Arg Asp Lys Asp 
            420                 425                 430         


Glu His Tyr Arg Thr Tyr Asp Ala Tyr Ser Thr Phe Tyr Leu Asn Ser 
        435                 440                 445             


Ser Gly Leu Ile Cys Arg His Arg Leu Asp Lys Leu Met Pro Ser His 
    450                 455                 460                 


Ser Pro Pro Thr Pro Val Lys Lys Leu Leu Val Gly Ala Leu Val Ala 
465                 470                 475                 480 


Leu Gly Leu Ser Glu Pro Glu Pro Asp Leu Asn Leu Cys Ser Lys Pro 
                485                 490                 495     


<210>  2007
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  2007

Met Ala Arg Arg Arg Ser Gln Arg Val Cys Ala Ser Gly Pro Ser Met 
1               5                   10                  15      


Leu Asn Ser Ala Arg Gly Ala Pro Glu Leu Leu Arg Gly Thr Ala Thr 
            20                  25                  30          


Asn Ala Glu Val Ser Ala Ala Ala Ala Gly Ala Thr Gly Ser Glu Glu 
        35                  40                  45              


Leu Pro Pro Gly Asp Arg Gly Cys Arg Asn Gly Gly Gly Arg Gly Pro 
    50                  55                  60                  


Ala Ala Thr Thr Ser Ser Thr Gly Val Ala Val Gly Ala Glu His Gly 
65                  70                  75                  80  


Glu Asp Ser Leu Ser Arg Lys Pro Asp Pro Glu Pro Gly Arg Met Asp 
                85                  90                  95      


His His Gln Pro Gly Thr Gly Arg Tyr Gln Val Leu Leu Asn Glu Glu 
            100                 105                 110         


Asp Asn Ser Glu Ser Ser Ala Ile Glu Gln Pro Pro Thr Ser Asn Pro 
        115                 120                 125             


Ala Pro Gln Ile Val Gln Ala Ala Ser Ser Ala Pro Ala Leu Glu Thr 
    130                 135                 140                 


Asp Ser Ser Pro Pro Pro Tyr Ser Ser Ile Thr Val Glu Val Pro Thr 
145                 150                 155                 160 


Thr Ser Asp Thr Glu Val Tyr Gly Glu Phe Tyr Pro Val Pro Pro Pro 
                165                 170                 175     


Tyr Ser Val Ala Thr Ser Leu Pro Thr Tyr Asp Glu Ala Glu Lys Ala 
            180                 185                 190         


Lys Ala Ala Ala Met Ala Ala Ala Ala Ala Glu Thr Ser Gln Arg Ile 
        195                 200                 205             


Gln Glu Glu Glu Cys Pro Pro Arg Asp Asp Phe Ser Asp Ala Asp Gln 
    210                 215                 220                 


Leu Arg Val Gly Asn Asp Gly Ile Phe Met Leu Ala Phe Phe Thr Gly 
225                 230                 235                 240 


Arg Tyr Gly Ala Ile Cys Gly Phe Gly Leu Ser Leu Ile Lys Trp Ile 
                245                 250                 255     


Leu Ile Val Arg Phe Ser Asp Tyr Phe Thr Gly Tyr Phe Asn Gly Gln 
            260                 265                 270         


Tyr Trp Leu Trp Trp Ile Phe Leu Val Leu Gly Leu Leu Leu Phe Phe 
        275                 280                 285             


Arg Gly Phe Val Asn Tyr Leu Lys Val Arg Asn Met Ser Glu Ser Met 
    290                 295                 300                 


Ala Ala Ala His Arg Thr Arg Tyr Phe Phe Leu Leu 
305                 310                 315     


<210>  2008
<211>  367
<212>  PRT
<213>  Homo sapiens

<400>  2008

Met Ser Lys Arg Ser Trp Trp Ala Gly Ser Arg Lys Pro Pro Arg Glu 
1               5                   10                  15      


Met Leu Lys Leu Ser Gly Ser Asp Ser Ser Gln Ser Met Asn Gly Leu 
            20                  25                  30          


Glu Val Ala Pro Pro Gly Leu Ile Thr Asn Phe Ser Leu Ala Thr Ala 
        35                  40                  45              


Glu Gln Cys Gly Gln Glu Thr Pro Leu Glu Asn Met Leu Phe Ala Ser 
    50                  55                  60                  


Phe Tyr Leu Leu Asp Phe Ile Leu Ala Leu Val Gly Asn Thr Leu Ala 
65                  70                  75                  80  


Leu Trp Leu Phe Ile Arg Asp His Lys Ser Gly Thr Pro Ala Asn Val 
                85                  90                  95      


Phe Leu Met His Leu Ala Val Ala Asp Leu Ser Cys Val Leu Val Leu 
            100                 105                 110         


Pro Thr Arg Leu Val Tyr His Phe Ser Gly Asn His Trp Pro Phe Gly 
        115                 120                 125             


Glu Ile Ala Cys Arg Leu Thr Gly Phe Leu Phe Tyr Leu Asn Met Tyr 
    130                 135                 140                 


Ala Ser Ile Tyr Phe Leu Thr Cys Ile Ser Ala Asp Arg Phe Leu Ala 
145                 150                 155                 160 


Ile Val His Pro Val Lys Ser Leu Lys Leu Arg Arg Pro Leu Tyr Ala 
                165                 170                 175     


His Leu Ala Cys Ala Phe Leu Trp Val Val Val Ala Val Ala Met Ala 
            180                 185                 190         


Pro Leu Leu Val Ser Pro Gln Thr Val Gln Thr Asn His Thr Val Val 
        195                 200                 205             


Cys Leu Gln Leu Tyr Arg Glu Lys Ala Ser His His Ala Leu Val Ser 
    210                 215                 220                 


Leu Ala Val Ala Phe Thr Phe Pro Phe Ile Thr Thr Val Thr Cys Tyr 
225                 230                 235                 240 


Leu Leu Ile Ile Arg Ser Leu Arg Gln Gly Leu Arg Val Glu Lys Arg 
                245                 250                 255     


Leu Lys Thr Lys Ala Val Arg Met Ile Ala Ile Val Leu Ala Ile Phe 
            260                 265                 270         


Leu Val Cys Phe Val Pro Tyr His Val Asn Arg Ser Val Tyr Val Leu 
        275                 280                 285             


His Tyr Arg Ser His Gly Ala Ser Cys Ala Thr Gln Arg Ile Leu Ala 
    290                 295                 300                 


Leu Ala Asn Arg Ile Thr Ser Cys Leu Thr Ser Leu Asn Gly Ala Leu 
305                 310                 315                 320 


Asp Pro Ile Met Tyr Phe Phe Val Ala Glu Lys Phe Arg His Ala Leu 
                325                 330                 335     


Cys Asn Leu Leu Cys Gly Lys Arg Leu Lys Gly Pro Pro Pro Ser Phe 
            340                 345                 350         


Glu Gly Lys Thr Asn Glu Ser Ser Leu Ser Ala Lys Ser Glu Leu 
        355                 360                 365         


<210>  2009
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  2009

Met Asn Gly Leu Glu Val Ala Pro Pro Gly Leu Ile Thr Asn Phe Ser 
1               5                   10                  15      


Leu Ala Thr Ala Glu Gln Cys Gly Gln Glu Thr Pro Leu Glu Asn Met 
            20                  25                  30          


Leu Phe Ala Ser Phe Tyr Leu Leu Asp Phe Ile Leu Ala Leu Val Gly 
        35                  40                  45              


Asn Thr Leu Ala Leu Trp Leu Phe Ile Arg Asp His Lys Ser Gly Thr 
    50                  55                  60                  


Pro Ala Asn Val Phe Leu Met His Leu Ala Val Ala Asp Leu Ser Cys 
65                  70                  75                  80  


Val Leu Val Leu Pro Thr Arg Leu Val Tyr His Phe Ser Gly Asn His 
                85                  90                  95      


Trp Pro Phe Gly Glu Ile Ala Cys Arg Leu Thr Gly Phe Leu Phe Tyr 
            100                 105                 110         


Leu Asn Met Tyr Ala Ser Ile Tyr Phe Leu Thr Cys Ile Ser Ala Asp 
        115                 120                 125             


Arg Phe Leu Ala Ile Val His Pro Val Lys Ser Leu Lys Leu Arg Arg 
    130                 135                 140                 


Pro Leu Tyr Ala His Leu Ala Cys Ala Phe Leu Trp Val Val Val Ala 
145                 150                 155                 160 


Val Ala Met Ala Pro Leu Leu Val Ser Pro Gln Thr Val Gln Thr Asn 
                165                 170                 175     


His Thr Val Val Cys Leu Gln Leu Tyr Arg Glu Lys Ala Ser His His 
            180                 185                 190         


Ala Leu Val Ser Leu Ala Val Ala Phe Thr Phe Pro Phe Ile Thr Thr 
        195                 200                 205             


Val Thr Cys Tyr Leu Leu Ile Ile Arg Ser Leu Arg Gln Gly Leu Arg 
    210                 215                 220                 


Val Glu Lys Arg Leu Lys Thr Lys Ala Val Arg Met Ile Ala Ile Val 
225                 230                 235                 240 


Leu Ala Ile Phe Leu Val Cys Phe Val Pro Tyr His Val Asn Arg Ser 
                245                 250                 255     


Val Tyr Val Leu His Tyr Arg Ser His Gly Ala Ser Cys Ala Thr Gln 
            260                 265                 270         


Arg Ile Leu Ala Leu Ala Asn Arg Ile Thr Ser Cys Leu Thr Ser Leu 
        275                 280                 285             


Asn Gly Ala Leu Asp Pro Ile Met Tyr Phe Phe Val Ala Glu Lys Phe 
    290                 295                 300                 


Arg His Ala Leu Cys Asn Leu Leu Cys Gly Lys Arg Leu Lys Gly Pro 
305                 310                 315                 320 


Pro Pro Ser Phe Glu Gly Lys Thr Asn Glu Ser Ser Leu Ser Ala Lys 
                325                 330                 335     


Ser Glu Leu 
            


<210>  2010
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  2010

Met Asn Gly Leu Glu Val Ala Pro Pro Gly Leu Ile Thr Asn Phe Ser 
1               5                   10                  15      


Leu Ala Thr Ala Glu Gln Cys Gly Gln Glu Thr Pro Leu Glu Asn Met 
            20                  25                  30          


Leu Phe Ala Ser Phe Tyr Leu Leu Asp Phe Ile Leu Ala Leu Val Gly 
        35                  40                  45              


Asn Thr Leu Ala Leu Trp Leu Phe Ile Arg Asp His Lys Ser Gly Thr 
    50                  55                  60                  


Pro Ala Asn Val Phe Leu Met His Leu Ala Val Ala Asp Leu Ser Cys 
65                  70                  75                  80  


Val Leu Val Leu Pro Thr Arg Leu Val Tyr His Phe Ser Gly Asn His 
                85                  90                  95      


Trp Pro Phe Gly Glu Ile Ala Cys Arg Leu Thr Gly Phe Leu Phe Tyr 
            100                 105                 110         


Leu Asn Met Tyr Ala Ser Ile Tyr Phe Leu Thr Cys Ile Ser Ala Asp 
        115                 120                 125             


Arg Phe Leu Ala Ile Val His Pro Val Lys Ser Leu Lys Leu Arg Arg 
    130                 135                 140                 


Pro Leu Tyr Ala His Leu Ala Cys Ala Phe Leu Trp Val Val Val Ala 
145                 150                 155                 160 


Val Ala Met Ala Pro Leu Leu Val Ser Pro Gln Thr Val Gln Thr Asn 
                165                 170                 175     


His Thr Val Val Cys Leu Gln Leu Tyr Arg Glu Lys Ala Ser His His 
            180                 185                 190         


Ala Leu Val Ser Leu Ala Val Ala Phe Thr Phe Pro Phe Ile Thr Thr 
        195                 200                 205             


Val Thr Cys Tyr Leu Leu Ile Ile Arg Ser Leu Arg Gln Gly Leu Arg 
    210                 215                 220                 


Val Glu Lys Arg Leu Lys Thr Lys Ala Val Arg Met Ile Ala Ile Val 
225                 230                 235                 240 


Leu Ala Ile Phe Leu Val Cys Phe Val Pro Tyr His Val Asn Arg Ser 
                245                 250                 255     


Val Tyr Val Leu His Tyr Arg Ser His Gly Ala Ser Cys Ala Thr Gln 
            260                 265                 270         


Arg Ile Leu Ala Leu Ala Asn Arg Ile Thr Ser Cys Leu Thr Ser Leu 
        275                 280                 285             


Asn Gly Ala Leu Asp Pro Ile Met Tyr Phe Phe Val Ala Glu Lys Phe 
    290                 295                 300                 


Arg His Ala Leu Cys Asn Leu Leu Cys Gly Lys Arg Leu Lys Gly Pro 
305                 310                 315                 320 


Pro Pro Ser Phe Glu Gly Lys Thr Asn Glu Ser Ser Leu Ser Ala Lys 
                325                 330                 335     


Ser Glu Leu 
            


<210>  2011
<211>  937
<212>  PRT
<213>  Homo sapiens

<400>  2011

Met Ala Gly Ala Gly Gly Gly Leu Gly Val Trp Gly Asn Leu Val Leu 
1               5                   10                  15      


Leu Gly Leu Cys Ser Trp Thr Gly Ala Arg Ala Pro Ala Pro Asn Pro 
            20                  25                  30          


Gly Arg Asn Leu Thr Val Glu Thr Gln Thr Thr Ser Ser Ile Ser Leu 
        35                  40                  45              


Ser Trp Glu Val Pro Asp Gly Leu Asp Ser Gln Asn Ser Asn Tyr Trp 
    50                  55                  60                  


Val Gln Cys Thr Gly Asp Gly Gly Thr Thr Glu Thr Arg Asn Thr Thr 
65                  70                  75                  80  


Ala Thr Asn Val Thr Val Asp Gly Leu Gly Pro Gly Ser Leu Tyr Thr 
                85                  90                  95      


Cys Ser Val Trp Val Glu Lys Asp Gly Val Asn Ser Ser Val Gly Thr 
            100                 105                 110         


Val Thr Thr Ala Thr Ala Pro Asn Pro Val Arg Asn Leu Thr Val Glu 
        115                 120                 125             


Ala Gln Thr Asn Ser Ser Ile Ala Leu Thr Trp Glu Val Pro Asp Gly 
    130                 135                 140                 


Pro Asp Pro Gln Asn Ser Thr Tyr Gly Val Glu Tyr Thr Gly Asp Gly 
145                 150                 155                 160 


Gly Arg Ala Gly Thr Arg Ser Thr Ala His Thr Asn Ile Thr Val Asp 
                165                 170                 175     


Arg Leu Glu Pro Gly Cys Leu Tyr Val Phe Ser Val Trp Val Gly Lys 
            180                 185                 190         


Asn Gly Ile Asn Ser Ser Arg Glu Thr Arg Asn Ala Thr Thr Ala Pro 
        195                 200                 205             


Asn Pro Val Arg Asn Leu His Met Glu Thr Gln Thr Asn Ser Ser Ile 
    210                 215                 220                 


Ala Leu Cys Trp Glu Val Pro Asp Gly Pro Tyr Pro Gln Asp Tyr Thr 
225                 230                 235                 240 


Tyr Trp Val Glu Tyr Thr Gly Asp Gly Gly Gly Thr Glu Thr Arg Asn 
                245                 250                 255     


Thr Thr Asn Thr Ser Val Thr Ala Glu Arg Leu Glu Pro Gly Thr Leu 
            260                 265                 270         


Tyr Thr Phe Ser Val Trp Ala Glu Lys Asn Gly Ala Arg Gly Ser Arg 
        275                 280                 285             


Gln Asn Val Ser Ile Ser Thr Val Pro Asn Ala Val Thr Ser Leu Ser 
    290                 295                 300                 


Lys Gln Asp Trp Thr Asn Ser Thr Ile Ala Leu Arg Trp Thr Ala Pro 
305                 310                 315                 320 


Gln Gly Pro Gly Gln Ser Ser Tyr Ser Tyr Trp Val Ser Trp Val Arg 
                325                 330                 335     


Glu Gly Met Thr Asp Pro Arg Thr Gln Ser Thr Ser Gly Thr Asp Ile 
            340                 345                 350         


Thr Leu Lys Glu Leu Glu Ala Gly Ser Leu Tyr His Leu Thr Val Trp 
        355                 360                 365             


Ala Glu Arg Asn Glu Val Arg Gly Tyr Asn Ser Thr Leu Thr Ala Ala 
    370                 375                 380                 


Thr Ala Pro Asn Glu Val Thr Asp Leu Gln Asn Glu Thr Gln Thr Lys 
385                 390                 395                 400 


Asn Ser Val Met Leu Trp Trp Lys Ala Pro Gly Asp Pro His Ser Gln 
                405                 410                 415     


Leu Tyr Val Tyr Trp Val Gln Trp Ala Ser Lys Gly His Pro Arg Arg 
            420                 425                 430         


Gly Gln Asp Pro Gln Ala Asn Trp Val Asn Gln Thr Ser Arg Thr Asn 
        435                 440                 445             


Glu Thr Trp Tyr Lys Val Glu Ala Leu Glu Pro Gly Thr Leu Tyr Asn 
    450                 455                 460                 


Phe Thr Val Trp Ala Glu Arg Asn Asp Val Ala Ser Ser Thr Gln Ser 
465                 470                 475                 480 


Leu Cys Ala Ser Thr Tyr Pro Asp Thr Val Thr Ile Thr Ser Cys Val 
                485                 490                 495     


Ser Thr Ser Ala Gly Tyr Gly Val Asn Leu Ile Trp Ser Cys Pro Gln 
            500                 505                 510         


Gly Gly Tyr Glu Ala Phe Glu Leu Glu Val Gly Gly Gln Arg Gly Ser 
        515                 520                 525             


Gln Asp Arg Ser Ser Cys Gly Glu Ala Val Ser Val Leu Gly Leu Gly 
    530                 535                 540                 


Pro Ala Arg Ser Tyr Pro Ala Thr Ile Thr Thr Ile Trp Asp Gly Met 
545                 550                 555                 560 


Lys Val Val Ser His Ser Val Val Cys His Thr Glu Ser Ala Gly Val 
                565                 570                 575     


Ile Ala Gly Ala Phe Val Gly Ile Leu Leu Phe Leu Ile Leu Val Gly 
            580                 585                 590         


Leu Leu Ile Phe Phe Leu Lys Arg Arg Asn Lys Lys Lys Gln Gln Lys 
        595                 600                 605             


Pro Glu Leu Arg Asp Leu Val Phe Ser Ser Pro Gly Asp Ile Pro Ala 
    610                 615                 620                 


Glu Asp Phe Ala Asp His Val Arg Lys Asn Glu Arg Asp Ser Asn Cys 
625                 630                 635                 640 


Gly Phe Ala Asp Glu Tyr Gln Gln Leu Ser Leu Val Gly His Ser Gln 
                645                 650                 655     


Ser Gln Met Val Ala Ser Ala Ser Glu Asn Asn Ala Lys Asn Arg Tyr 
            660                 665                 670         


Arg Asn Val Leu Pro Tyr Asp Trp Ser Arg Val Pro Leu Lys Pro Ile 
        675                 680                 685             


His Glu Glu Pro Gly Ser Asp Tyr Ile Asn Ala Ser Phe Met Pro Gly 
    690                 695                 700                 


Leu Trp Ser Pro Gln Glu Phe Ile Ala Thr Gln Gly Pro Leu Pro Gln 
705                 710                 715                 720 


Thr Val Gly Asp Phe Trp Arg Leu Val Trp Glu Gln Gln Ser His Thr 
                725                 730                 735     


Leu Val Met Leu Thr Asn Cys Met Glu Ala Gly Arg Val Lys Cys Glu 
            740                 745                 750         


His Tyr Trp Pro Leu Asp Ser Gln Pro Cys Thr His Gly His Leu Arg 
        755                 760                 765             


Val Thr Leu Val Gly Glu Glu Val Met Glu Asn Trp Thr Val Arg Glu 
    770                 775                 780                 


Leu Leu Leu Leu Gln Val Glu Glu Gln Lys Thr Leu Ser Val Arg Gln 
785                 790                 795                 800 


Phe His Tyr Gln Ala Trp Pro Asp His Gly Val Pro Ser Ser Pro Asp 
                805                 810                 815     


Thr Leu Leu Ala Phe Trp Arg Met Leu Arg Gln Trp Leu Asp Gln Thr 
            820                 825                 830         


Met Glu Gly Gly Pro Pro Ile Val His Cys Ser Ala Gly Val Gly Arg 
        835                 840                 845             


Thr Gly Thr Leu Ile Ala Leu Asp Val Leu Leu Arg Gln Leu Gln Ser 
    850                 855                 860                 


Glu Gly Leu Leu Gly Pro Phe Ser Phe Val Arg Lys Met Arg Glu Ser 
865                 870                 875                 880 


Arg Pro Leu Met Val Gln Thr Glu Ala Gln Tyr Val Phe Leu His Gln 
                885                 890                 895     


Cys Ile Leu Arg Phe Leu Gln Gln Ser Ala Gln Ala Pro Ala Glu Lys 
            900                 905                 910         


Glu Val Pro Tyr Glu Asp Val Glu Asn Leu Ile Tyr Glu Asn Val Ala 
        915                 920                 925             


Ala Ile Gln Ala His Lys Leu Glu Val 
    930                 935         


<210>  2012
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  2012

Met Val Ser Gly Arg Phe Tyr Leu Ser Cys Leu Leu Leu Gly Ser Leu 
1               5                   10                  15      


Gly Ser Met Cys Ile Leu Phe Thr Ile Tyr Trp Met Gln Tyr Trp Arg 
            20                  25                  30          


Gly Gly Phe Ala Trp Asn Gly Ser Ile Tyr Met Phe Asn Trp His Pro 
        35                  40                  45              


Val Leu Met Val Ala Gly Met Val Val Phe Tyr Gly Gly Ala Ser Leu 
    50                  55                  60                  


Val Tyr Arg Leu Pro Gln Ser Trp Val Gly Pro Lys Leu Pro Trp Lys 
65                  70                  75                  80  


Leu Leu His Ala Ala Leu His Leu Met Ala Phe Val Leu Thr Val Val 
                85                  90                  95      


Gly Leu Val Ala Val Phe Thr Phe His Asn His Gly Arg Thr Ala Asn 
            100                 105                 110         


Leu Tyr Ser Leu His Ser Trp Leu Gly Ile Thr Thr Val Phe Leu Phe 
        115                 120                 125             


Ala Cys Gln Trp Phe Leu Gly Phe Ala Val Phe Leu Leu Pro Trp Ala 
    130                 135                 140                 


Ser Met Trp Leu Arg Ser Leu Leu Lys Pro Ile His Val Phe Phe Gly 
145                 150                 155                 160 


Ala Ala Ile Leu Ser Leu Ser Ile Ala Ser Val Ile Ser Gly Ile Asn 
                165                 170                 175     


Glu Lys Leu Phe Phe Ser Leu Lys Asn Thr Thr Arg Pro Tyr His Ser 
            180                 185                 190         


Leu Pro Ser Glu Ala Val Phe Ala Asn Ser Thr Gly Met Leu Val Val 
        195                 200                 205             


Ala Phe Gly Leu Leu Val Leu Tyr Ile Leu Leu Ala Ser Ser Trp Lys 
    210                 215                 220                 


Arg Pro Glu Pro Gly Ile Leu Thr Asp Arg Gln Pro Leu Leu His Asp 
225                 230                 235                 240 


Gly Glu 
        


<210>  2013
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  2013

Met Gly Lys Asn Phe Ser Asp Ser Phe Leu Ser Arg Glu Cys Val Ile 
1               5                   10                  15      


Arg Met Val Ser Gly Arg Phe Tyr Leu Ser Cys Leu Leu Leu Gly Ser 
            20                  25                  30          


Leu Gly Ser Met Cys Ile Leu Phe Thr Ile Tyr Trp Met Gln Tyr Trp 
        35                  40                  45              


Arg Gly Gly Phe Ala Trp Asn Gly Ser Ile Tyr Met Phe Asn Trp His 
    50                  55                  60                  


Pro Val Leu Met Val Ala Gly Met Val Val Phe Tyr Gly Gly Ala Ser 
65                  70                  75                  80  


Leu Val Tyr Arg Leu Pro Gln Ser Trp Val Gly Pro Lys Leu Pro Trp 
                85                  90                  95      


Lys Leu Leu His Ala Ala Leu His Leu Met Ala Phe Val Leu Thr Val 
            100                 105                 110         


Val Gly Leu Val Ala Val Phe Thr Phe His Asn His Gly Arg Thr Ala 
        115                 120                 125             


Asn Leu Tyr Ser Leu His Ser Trp Leu Gly Ile Thr Thr Val Phe Leu 
    130                 135                 140                 


Phe Ala Cys Gln Trp Phe Leu Gly Phe Ala Val Phe Leu Leu Pro Trp 
145                 150                 155                 160 


Ala Ser Met Trp Leu Arg Ser Leu Leu Lys Pro Ile His Val Phe Phe 
                165                 170                 175     


Gly Ala Ala Ile Leu Ser Leu Ser Ile Ala Ser Val Ile Ser Gly Ile 
            180                 185                 190         


Asn Glu Lys Leu Phe Phe Ser Leu Lys Asn Thr Thr Arg Pro Tyr His 
        195                 200                 205             


Ser Leu Pro Ser Glu Ala Val Phe Ala Asn Ser Thr Gly Met Leu Val 
    210                 215                 220                 


Val Ala Phe Gly Leu Leu Val Leu Tyr Ile Leu Leu Ala Ser Ser Trp 
225                 230                 235                 240 


Lys Arg Pro Glu Pro Gly Ile Leu Thr Asp Arg Gln Pro Leu Leu His 
                245                 250                 255     


Asp Gly Glu 
            


<210>  2014
<211>  548
<212>  PRT
<213>  Homo sapiens

<400>  2014

Met Ala Arg Leu Thr Lys Arg Arg Gln Ala Asp Thr Lys Ala Ile Gln 
1               5                   10                  15      


His Leu Trp Ala Ala Ile Glu Ile Ile Arg Asn Gln Lys Gln Ile Ala 
            20                  25                  30          


Asn Ile Asp Arg Ile Thr Lys Tyr Met Ser Arg Val His Gly Met His 
        35                  40                  45              


Pro Lys Glu Thr Thr Arg Gln Leu Ser Leu Ala Val Lys Asp Gly Leu 
    50                  55                  60                  


Ile Val Glu Thr Leu Thr Val Gly Cys Lys Gly Ser Lys Ala Gly Ile 
65                  70                  75                  80  


Glu Gln Glu Gly Tyr Trp Leu Pro Gly Asp Glu Ile Ser Ile Lys Lys 
                85                  90                  95      


Lys Asn Thr Asn Lys Gln Glu Met Gly Thr Tyr Leu Arg Phe Ile Val 
            100                 105                 110         


Ser Arg Met Lys Glu Arg Ala Ile Asp Leu Asn Lys Lys Gly Lys Asp 
        115                 120                 125             


Asn Lys His Pro Met Tyr Arg Arg Leu Val His Ser Ala Val Asp Val 
    130                 135                 140                 


Pro Thr Ile Gln Glu Lys Val Asn Glu Gly Lys Tyr Arg Ser Tyr Glu 
145                 150                 155                 160 


Glu Phe Lys Ala Asp Ala Gln Leu Leu Leu His Asn Thr Val Ile Phe 
                165                 170                 175     


Tyr Gly Ala Asp Ser Glu Gln Ala Asp Ile Ala Arg Met Leu Tyr Lys 
            180                 185                 190         


Asp Thr Cys His Glu Leu Asp Glu Leu Gln Leu Cys Lys Asn Cys Phe 
        195                 200                 205             


Tyr Leu Ser Asn Ala Arg Pro Asp Asn Trp Phe Cys Tyr Pro Cys Ile 
    210                 215                 220                 


Pro Asn His Glu Leu Val Trp Ala Lys Met Lys Gly Phe Gly Phe Trp 
225                 230                 235                 240 


Pro Ala Lys Val Met Gln Lys Glu Asp Asn Gln Val Asp Val Arg Phe 
                245                 250                 255     


Phe Gly His His His Gln Arg Ala Trp Ile Pro Ser Glu Asn Ile Gln 
            260                 265                 270         


Asp Ile Thr Val Asn Ile His Arg Leu His Val Lys Arg Ser Met Gly 
        275                 280                 285             


Trp Lys Lys Ala Cys Asp Glu Leu Glu Leu His Gln Arg Phe Leu Arg 
    290                 295                 300                 


Glu Gly Arg Phe Trp Lys Ser Lys Asn Glu Asp Arg Gly Glu Glu Glu 
305                 310                 315                 320 


Ala Glu Ser Ser Ile Ser Ser Thr Ser Asn Glu Gln Leu Lys Val Thr 
                325                 330                 335     


Gln Glu Pro Arg Ala Lys Lys Gly Arg Arg Asn Gln Ser Val Glu Pro 
            340                 345                 350         


Lys Lys Glu Glu Pro Glu Pro Glu Thr Glu Ala Val Ser Ser Ser Gln 
        355                 360                 365             


Glu Ile Pro Thr Met Pro Gln Pro Ile Glu Lys Val Ser Val Ser Thr 
    370                 375                 380                 


Gln Thr Lys Lys Leu Ser Ala Ser Ser Pro Arg Met Leu His Arg Ser 
385                 390                 395                 400 


Thr Gln Thr Thr Asn Asp Gly Val Cys Gln Ser Met Cys His Asp Lys 
                405                 410                 415     


Tyr Thr Lys Ile Phe Asn Asp Phe Lys Asp Arg Met Lys Ser Asp His 
            420                 425                 430         


Lys Arg Glu Thr Glu Arg Val Val Arg Glu Ala Leu Glu Lys Leu Arg 
        435                 440                 445             


Ser Glu Met Glu Glu Glu Lys Arg Gln Ala Val Asn Lys Ala Val Ala 
    450                 455                 460                 


Asn Met Gln Gly Glu Met Asp Arg Lys Cys Lys Gln Val Lys Glu Lys 
465                 470                 475                 480 


Cys Lys Glu Glu Phe Val Glu Glu Ile Lys Lys Leu Ala Thr Gln His 
                485                 490                 495     


Lys Gln Leu Ile Ser Gln Thr Lys Lys Lys Gln Trp Cys Tyr Asn Cys 
            500                 505                 510         


Glu Glu Glu Ala Met Tyr His Cys Cys Trp Asn Thr Ser Tyr Cys Ser 
        515                 520                 525             


Ile Lys Cys Gln Gln Glu His Trp His Ala Glu His Lys Arg Thr Cys 
    530                 535                 540                 


Arg Arg Lys Arg 
545             


<210>  2015
<211>  597
<212>  PRT
<213>  Homo sapiens

<400>  2015

Met Val Trp Leu Glu Ala Arg Pro Gln Ile Leu Phe Val Cys Thr Lys 
1               5                   10                  15      


Gln Gly His Gln Lys Pro Leu Asp Ser Lys Asp Asp Asn Thr Glu Lys 
            20                  25                  30          


His Cys Pro Val Thr Val Asn Pro Trp His Met Lys Lys Ala Phe Lys 
        35                  40                  45              


Val Met Asn Glu Leu Arg Ser Gln Asn Leu Leu Cys Asp Val Thr Ile 
    50                  55                  60                  


Val Ala Glu Asp Met Glu Ile Ser Ala His Arg Val Val Leu Ala Ala 
65                  70                  75                  80  


Cys Ser Pro Tyr Phe His Ala Met Phe Thr Gly Glu Met Ser Glu Ser 
                85                  90                  95      


Arg Ala Lys Arg Val Arg Ile Lys Glu Val Asp Gly Trp Thr Leu Arg 
            100                 105                 110         


Met Leu Ile Asp Tyr Val Tyr Thr Ala Glu Ile Gln Val Thr Glu Glu 
        115                 120                 125             


Asn Val Gln Val Leu Leu Pro Ala Ala Gly Leu Leu Gln Leu Gln Asp 
    130                 135                 140                 


Val Lys Lys Thr Cys Cys Glu Phe Leu Glu Ser Gln Leu His Pro Val 
145                 150                 155                 160 


Asn Cys Leu Gly Ile Arg Ala Phe Ala Asp Met His Ala Cys Thr Asp 
                165                 170                 175     


Leu Leu Asn Lys Ala Asn Thr Tyr Ala Glu Gln His Phe Ala Asp Val 
            180                 185                 190         


Val Leu Ser Glu Glu Phe Leu Asn Leu Gly Ile Glu Gln Val Cys Ser 
        195                 200                 205             


Leu Ile Ser Ser Asp Lys Leu Thr Ile Ser Ser Glu Glu Lys Val Phe 
    210                 215                 220                 


Glu Ala Val Ile Ala Trp Val Asn His Asp Lys Asp Val Arg Gln Glu 
225                 230                 235                 240 


Phe Met Ala Arg Leu Met Glu His Val Arg Leu Pro Leu Leu Pro Arg 
                245                 250                 255     


Glu Tyr Leu Val Gln Arg Val Glu Glu Glu Ala Leu Val Lys Asn Ser 
            260                 265                 270         


Ser Ala Cys Lys Asp Tyr Leu Ile Glu Ala Met Lys Tyr His Leu Leu 
        275                 280                 285             


Pro Thr Glu Gln Arg Ile Leu Met Lys Ser Val Arg Thr Arg Leu Arg 
    290                 295                 300                 


Thr Pro Met Asn Leu Pro Lys Leu Met Val Val Val Gly Gly Gln Ala 
305                 310                 315                 320 


Pro Lys Ala Ile Arg Ser Val Glu Cys Tyr Asp Phe Lys Glu Glu Arg 
                325                 330                 335     


Trp His Gln Val Ala Glu Leu Pro Ser Arg Arg Cys Arg Ala Gly Met 
            340                 345                 350         


Val Tyr Met Ala Gly Leu Val Phe Ala Val Gly Gly Phe Asn Gly Ser 
        355                 360                 365             


Leu Arg Val Arg Thr Val Asp Ser Tyr Asp Pro Val Lys Asp Gln Trp 
    370                 375                 380                 


Thr Ser Val Ala Asn Met Arg Asp Arg Arg Ser Thr Leu Gly Ala Ala 
385                 390                 395                 400 


Val Leu Asn Gly Leu Leu Tyr Ala Val Gly Gly Phe Asp Gly Ser Thr 
                405                 410                 415     


Gly Leu Ser Ser Val Glu Ala Tyr Asn Ile Lys Ser Asn Glu Trp Phe 
            420                 425                 430         


His Val Ala Pro Met Asn Thr Arg Arg Ser Ser Val Gly Val Gly Val 
        435                 440                 445             


Val Gly Gly Leu Leu Tyr Ala Val Gly Gly Tyr Asp Gly Ala Ser Arg 
    450                 455                 460                 


Gln Cys Leu Ser Thr Val Glu Cys Tyr Asn Ala Thr Thr Asn Glu Trp 
465                 470                 475                 480 


Thr Tyr Ile Ala Glu Met Ser Thr Arg Arg Ser Gly Ala Gly Val Gly 
                485                 490                 495     


Val Leu Asn Asn Leu Leu Tyr Ala Val Gly Gly His Asp Gly Pro Leu 
            500                 505                 510         


Val Arg Lys Ser Val Glu Val Tyr Asp Pro Thr Thr Asn Ala Trp Arg 
        515                 520                 525             


Gln Val Ala Asp Met Asn Met Cys Arg Arg Asn Ala Gly Val Cys Ala 
    530                 535                 540                 


Val Asn Gly Leu Leu Tyr Val Val Gly Gly Asp Asp Gly Ser Cys Asn 
545                 550                 555                 560 


Leu Ala Ser Val Glu Tyr Tyr Asn Pro Thr Thr Asp Lys Trp Thr Val 
                565                 570                 575     


Val Ser Ser Cys Met Ser Thr Gly Arg Ser Tyr Ala Gly Val Thr Val 
            580                 585                 590         


Ile Asp Lys Pro Leu 
        595         


<210>  2016
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  2016

Met Ser Glu Ser Arg Ala Lys Arg Val Arg Ile Lys Glu Val Asp Gly 
1               5                   10                  15      


Trp Thr Leu Arg Met Leu Ile Asp Tyr Val Tyr Thr Ala Glu Ile Gln 
            20                  25                  30          


Val Thr Glu Glu Asn Val Gln Val Leu Leu Pro Ala Ala Gly Leu Leu 
        35                  40                  45              


Gln Leu Gln Asp Val Lys Lys Thr Cys Cys Glu Phe Leu Glu Ser Gln 
    50                  55                  60                  


Leu His Pro Val Asn Cys Leu Gly Ile Arg Ala Phe Ala Asp Met His 
65                  70                  75                  80  


Ala Cys Thr Asp Leu Leu Asn Lys Ala Asn Thr Tyr Ala Glu Gln His 
                85                  90                  95      


Phe Ala Asp Val Val Leu Ser Glu Glu Phe Leu Asn Leu Gly Ile Glu 
            100                 105                 110         


Gln Val Cys Ser Leu Ile Ser Ser Asp Lys Leu Thr Ile Ser Ser Glu 
        115                 120                 125             


Glu Lys Val Phe Glu Ala Val Ile Ala Trp Val Asn His Asp Lys Asp 
    130                 135                 140                 


Val Arg Gln Glu Phe Met Ala Arg Leu Met Glu His Val Arg Leu Pro 
145                 150                 155                 160 


Leu Leu Pro Arg Glu Tyr Leu Val Gln Arg Val Glu Glu Glu Ala Leu 
                165                 170                 175     


Val Lys Asn Ser Ser Ala Cys Lys Asp Tyr Leu Ile Glu Ala Met Lys 
            180                 185                 190         


Tyr His Leu Leu Pro Thr Glu Gln Arg Ile Leu Met Lys Ser Val Arg 
        195                 200                 205             


Thr Arg Leu Arg Thr Pro Met Asn Leu Pro Lys Leu Met Val Val Val 
    210                 215                 220                 


Gly Gly Gln Ala Pro Lys Ala Ile Arg Ser Val Glu Cys Tyr Asp Phe 
225                 230                 235                 240 


Lys Glu Glu Arg Trp His Gln Val Ala Glu Leu Pro Ser Arg Arg Cys 
                245                 250                 255     


Arg Ala Gly Met Val Tyr Met Ala Gly Leu Val Phe Ala Val Gly Gly 
            260                 265                 270         


Phe Asn Gly Ser Leu Arg Val Arg Thr Val Asp Ser Tyr Asp Pro Val 
        275                 280                 285             


Lys Asp Gln Trp Thr Ser Val Ala Asn Met Arg Asp Arg Arg Ser Thr 
    290                 295                 300                 


Leu Gly Ala Ala Val Leu Asn Gly Leu Leu Tyr Ala Val Gly Gly Phe 
305                 310                 315                 320 


Asp Gly Ser Thr Gly Leu Ser Ser Val Glu Ala Tyr Asn Ile Lys Ser 
                325                 330                 335     


Asn Glu Trp Phe His Val Ala Pro Met Asn Thr Arg Arg Ser Ser Val 
            340                 345                 350         


Gly Val Gly Val Val Gly Gly Leu Leu Tyr Ala Val Gly Gly Tyr Asp 
        355                 360                 365             


Gly Ala Ser Arg Gln Cys Leu Ser Thr Val Glu Cys Tyr Asn Ala Thr 
    370                 375                 380                 


Thr Asn Glu Trp Thr Tyr Ile Ala Glu Met Ser Thr Arg Arg Ser Gly 
385                 390                 395                 400 


Ala Gly Val Gly Val Leu Asn Asn Leu Leu Tyr Ala Val Gly Gly His 
                405                 410                 415     


Asp Gly Pro Leu Val Arg Lys Ser Val Glu Val Tyr Asp Pro Thr Thr 
            420                 425                 430         


Asn Ala Trp Arg Gln Val Ala Asp Met Asn Met Cys Arg Arg Asn Ala 
        435                 440                 445             


Gly Val Cys Ala Val Asn Gly Leu Leu Tyr Val Val Gly Gly Asp Asp 
    450                 455                 460                 


Gly Ser Cys Asn Leu Ala Ser Val Glu Tyr Tyr Asn Pro Thr Thr Asp 
465                 470                 475                 480 


Lys Trp Thr Val Val Ser Ser Cys Met Ser Thr Gly Arg Ser Tyr Ala 
                485                 490                 495     


Gly Val Thr Val Ile Asp Lys Pro Leu 
            500                 505 


<210>  2017
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  2017

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser 
65                  70                  75                  80  


Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val 
                85                  90                  95      


His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro 
            100                 105                 110         


Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile 
        115                 120                 125             


Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala 
    130                 135                 140                 


Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg 
145                 150                 155                 160 


Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val 
                165                 170                 175     


Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe 
            180                 185                 190         


Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser 
        195                 200                 205             


Leu Leu Asp Thr Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val 
    210                 215                 220                 


Thr Val Arg Cys Asn Thr Thr His Cys Leu Val Arg Trp Lys Gln Pro 
225                 230                 235                 240 


Arg Thr Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp 
                245                 250                 255     


Val His Arg Lys Asn Thr Gln Pro Gly Thr Glu Asn Leu Leu Ile Asn 
            260                 265                 270         


Val Ser Gly Asp Leu Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro 
        275                 280                 285             


Arg Ala Lys His Ser Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu 
    290                 295                 300                 


Asn Trp Ser Ser Trp Ser Glu Ala Ile Glu Phe Gly Ser Asp Asp Gly 
305                 310                 315                 320 


Asn Leu Gly Ser Val Tyr Ile Tyr Val Leu Leu Ile Val Gly Thr Leu 
                325                 330                 335     


Val Cys Gly Ile Val Leu Gly Phe Leu Phe Lys Arg Phe Leu Arg Ile 
            340                 345                 350         


Gln Arg Leu Phe Pro Pro Val Pro Gln Ile Lys Asp Lys Leu Asn Asp 
        355                 360                 365             


Asn His Glu Val Glu Asp Glu Ile Ile Trp Glu Glu Phe Thr Pro Glu 
    370                 375                 380                 


Glu Gly Lys Gly Tyr Arg Glu Glu Val Leu Thr Val Lys Glu Ile Thr 
385                 390                 395                 400 


<210>  2018
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  2018

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser 
65                  70                  75                  80  


Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val 
                85                  90                  95      


His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro 
            100                 105                 110         


Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile 
        115                 120                 125             


Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala 
    130                 135                 140                 


Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg 
145                 150                 155                 160 


Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val 
                165                 170                 175     


Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe 
            180                 185                 190         


Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser 
        195                 200                 205             


Leu Leu Asp Thr Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val 
    210                 215                 220                 


Thr Val Arg Cys Asn Thr Thr His Cys Leu Val Arg Trp Lys Gln Pro 
225                 230                 235                 240 


Arg Thr Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp 
                245                 250                 255     


Val His Arg Lys Asn Thr Gln Pro Gly Thr Glu Asn Leu Leu Ile Asn 
            260                 265                 270         


Val Ser Gly Asp Leu Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro 
        275                 280                 285             


Arg Ala Lys His Ser Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu 
    290                 295                 300                 


Asn Trp Ser Ser Trp Ser Glu Ala Ile Glu Phe Gly Ser His Ser Val 
305                 310                 315                 320 


Thr Gln Ala Gly Val Gln Trp His Asn Leu Gly Ser Leu Gln Pro Pro 
                325                 330                 335     


Ser Pro Arg Leu Lys Arg Phe Ser Cys Leu Arg Leu Pro Gly Ser Asp 
            340                 345                 350         


Asp Gly Asn Leu Gly Ser Val Tyr Ile Tyr Val Leu Leu Ile Val Gly 
        355                 360                 365             


Thr Leu Val Cys Gly Ile Val Leu Gly Phe Leu Phe Lys Arg Phe Leu 
    370                 375                 380                 


Arg Ile Gln Arg Leu Phe Pro Pro Val Pro Gln Ile Lys Asp Lys Leu 
385                 390                 395                 400 


Asn Asp Asn His Glu Val Glu Asp Glu Ile Ile Trp Glu Glu Phe Thr 
                405                 410                 415     


Pro Glu Glu Gly Lys Gly Tyr Arg Glu Glu Val Leu Thr Val Lys Glu 
            420                 425                 430         


Ile Thr 
        


<210>  2019
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  2019

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser 
65                  70                  75                  80  


Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val 
                85                  90                  95      


His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro 
            100                 105                 110         


Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile 
        115                 120                 125             


Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala 
    130                 135                 140                 


Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg 
145                 150                 155                 160 


Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val 
                165                 170                 175     


Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe 
            180                 185                 190         


Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser 
        195                 200                 205             


Leu Leu Asp Thr Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val 
    210                 215                 220                 


Thr Val Arg Cys Asn Thr Thr His Cys Leu Val Arg Trp Lys Gln Pro 
225                 230                 235                 240 


Arg Thr Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp 
                245                 250                 255     


Val His Arg Lys Asn Thr Gln Pro Gly Thr Glu Asn Leu Leu Ile Asn 
            260                 265                 270         


Val Ser Gly Asp Leu Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro 
        275                 280                 285             


Arg Ala Lys His Ser Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu 
    290                 295                 300                 


Asn Trp Ser Ser Trp Ser Glu Ala Ile Glu Phe Gly Ser Asp Asp Gly 
305                 310                 315                 320 


Asn Leu Gly Ser Val Tyr Ile Tyr Val Leu Leu Ile Val Gly Thr Leu 
                325                 330                 335     


Val Cys Gly Ile Val Leu Gly Phe Leu Phe Lys Arg Phe Leu Arg Ile 
            340                 345                 350         


Gln Arg Leu Phe Pro Pro Val Pro Gln Ile Lys Asp Lys Leu Asn Asp 
        355                 360                 365             


Asn His Glu Val Glu Asp Glu Met Gly Pro Gln Arg His His Arg Cys 
    370                 375                 380                 


Gly Trp Asn Leu Tyr Pro Thr Pro Gly Pro Ser Pro Gly Ser Gly Ser 
385                 390                 395                 400 


Ser Pro Arg Leu Gly Ser Glu Ser Ser Leu 
                405                 410 


<210>  2020
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  2020

Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala Pro Arg Asp Val Gln 
1               5                   10                  15      


Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg Arg Glu Ile Arg Cys 
            20                  25                  30          


Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val Gly Cys His Leu Asp 
        35                  40                  45              


Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe Leu Val Asn Gly Thr 
    50                  55                  60                  


Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser Leu Leu Asp Thr Lys 
65                  70                  75                  80  


Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val Thr Val Arg Cys Asn 
                85                  90                  95      


Thr Thr His Cys Leu Val Arg Trp Lys Gln Pro Arg Thr Tyr Gln Lys 
            100                 105                 110         


Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp Val His Arg Lys Asn 
        115                 120                 125             


Thr Gln Pro Gly Thr Glu Asn Leu Leu Ile Asn Val Ser Gly Asp Leu 
    130                 135                 140                 


Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro Arg Ala Lys His Ser 
145                 150                 155                 160 


Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu Asn Trp Ser Ser Trp 
                165                 170                 175     


Ser Glu Ala Ile Glu Phe Gly Ser Asp Asp Gly Asn Leu Gly Ser Val 
            180                 185                 190         


Tyr Ile Tyr Val Leu Leu Ile Val Gly Thr Leu Val Cys Gly Ile Val 
        195                 200                 205             


Leu Gly Phe Leu Phe Lys Arg Phe Leu Arg Ile Gln Arg Leu Phe Pro 
    210                 215                 220                 


Pro Val Pro Gln Ile Lys Asp Lys Leu Asn Asp Asn His Glu Val Glu 
225                 230                 235                 240 


Asp Glu Ile Ile Trp Glu Glu Phe Thr Pro Glu Glu Gly Lys Gly Tyr 
                245                 250                 255     


Arg Glu Glu Val Leu Thr Val Lys Glu Ile Thr 
            260                 265         


<210>  2021
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  2021

Met Asn Phe Ile Leu Phe Ile Phe Ile Pro Gly Val Phe Ser Leu Lys 
1               5                   10                  15      


Ser Ser Thr Leu Lys Pro Thr Ile Glu Ala Leu Pro Asn Val Leu Pro 
            20                  25                  30          


Leu Asn Glu Asp Val Asn Lys Gln Glu Glu Lys Asn Glu Asp His Thr 
        35                  40                  45              


Pro Asn Tyr Ala Pro Ala Asn Glu Lys Asn Gly Asn Tyr Tyr Lys Asp 
    50                  55                  60                  


Ile Lys Gln Tyr Val Phe Thr Thr Gln Asn Pro Asn Gly Thr Glu Ser 
65                  70                  75                  80  


Glu Ile Ser Val Arg Ala Thr Thr Asp Leu Asn Phe Ala Leu Lys Asn 
                85                  90                  95      


Gly Ser Thr Pro Asn Val Pro Ala Phe Trp Thr Met Leu Ala Lys Ala 
            100                 105                 110         


Ile Asn Gly Thr Ala Val Val Met Asp Asp Lys Asp Gln Leu Phe His 
        115                 120                 125             


Pro Ile Pro Glu Ser Asp Val Asn Ala Thr Gln Gly Glu Asn Gln Pro 
    130                 135                 140                 


Asp Leu Glu Asp Leu Lys Ile Lys Ile Met Leu Gly Ile Ser Leu Met 
145                 150                 155                 160 


Thr Leu Leu Leu Phe Val Val Leu Leu Ala Phe Cys Ser Ala Thr Leu 
                165                 170                 175     


Tyr Lys Leu Arg His Leu Ser Tyr Lys Ser Cys Glu Ser Gln Tyr Ser 
            180                 185                 190         


Val Asn Pro Glu Leu Ala Thr Met Ser Tyr Phe His Pro Ser Glu Gly 
        195                 200                 205             


Val Ser Asp Thr Ser Phe Ser Lys Ser Ala Glu Ser Ser Thr Phe Leu 
    210                 215                 220                 


Gly Thr Thr Ser Ser Asp Met Arg Arg Ser Gly Thr Arg Thr Ser Glu 
225                 230                 235                 240 


Ser Lys Ile Met Thr Asp Ile Ile Ser Ile Gly Ser Asp Asn Glu Met 
                245                 250                 255     


His Glu Asn Asp Glu Ser Val Thr Arg 
            260                 265 


<210>  2022
<211>  600
<212>  PRT
<213>  Homo sapiens

<400>  2022

Met Lys Pro Phe Gln Leu Asp Leu Leu Phe Val Cys Phe Phe Leu Phe 
1               5                   10                  15      


Ser Gln Glu Leu Gly Leu Gln Lys Arg Gly Cys Cys Leu Val Leu Gly 
            20                  25                  30          


Tyr Met Ala Lys Asp Lys Phe Arg Arg Met Asn Glu Gly Gln Val Tyr 
        35                  40                  45              


Ser Phe Ser Gln Gln Pro Gln Asp Gln Val Val Val Ser Gly Gln Pro 
    50                  55                  60                  


Val Thr Leu Leu Cys Ala Ile Pro Glu Tyr Asp Gly Phe Val Leu Trp 
65                  70                  75                  80  


Ile Lys Asp Gly Leu Ala Leu Gly Val Gly Arg Asp Leu Ser Ser Tyr 
                85                  90                  95      


Pro Gln Tyr Leu Val Val Gly Asn His Leu Ser Gly Glu His His Leu 
            100                 105                 110         


Lys Ile Leu Arg Ala Glu Leu Gln Asp Asp Ala Val Tyr Glu Cys Gln 
        115                 120                 125             


Ala Ile Gln Ala Ala Ile Arg Ser Arg Pro Ala Arg Leu Thr Val Leu 
    130                 135                 140                 


Val Pro Pro Asp Asp Pro Val Ile Leu Gly Gly Pro Val Ile Ser Leu 
145                 150                 155                 160 


Arg Ala Gly Asp Pro Leu Asn Leu Thr Cys His Ala Asp Asn Ala Lys 
                165                 170                 175     


Pro Ala Ala Ser Ile Ile Trp Leu Arg Lys Gly Glu Val Ile Asn Gly 
            180                 185                 190         


Ala Thr Tyr Ser Lys Thr Leu Leu Arg Asp Gly Lys Arg Glu Ser Ile 
        195                 200                 205             


Val Ser Thr Leu Phe Ile Ser Pro Gly Asp Val Glu Asn Gly Gln Ser 
    210                 215                 220                 


Ile Val Cys Arg Ala Thr Asn Lys Ala Ile Pro Gly Gly Lys Glu Thr 
225                 230                 235                 240 


Ser Val Thr Ile Asp Ile Gln His Pro Pro Leu Val Asn Leu Ser Val 
                245                 250                 255     


Glu Pro Gln Pro Val Leu Glu Asp Asn Val Val Thr Phe His Cys Ser 
            260                 265                 270         


Ala Lys Ala Asn Pro Ala Val Thr Gln Tyr Arg Trp Ala Lys Arg Gly 
        275                 280                 285             


Gln Ile Ile Lys Glu Ala Ser Gly Glu Val Tyr Arg Thr Thr Val Asp 
    290                 295                 300                 


Tyr Thr Tyr Phe Ser Glu Pro Val Ser Cys Glu Val Thr Asn Ala Leu 
305                 310                 315                 320 


Gly Ser Thr Asn Leu Ser Arg Thr Val Asp Val Tyr Phe Gly Pro Arg 
                325                 330                 335     


Met Thr Thr Glu Pro Gln Ser Leu Leu Val Asp Leu Gly Ser Asp Ala 
            340                 345                 350         


Ile Phe Ser Cys Ala Trp Thr Gly Asn Pro Ser Leu Thr Ile Val Trp 
        355                 360                 365             


Met Lys Arg Gly Ser Gly Val Val Leu Ser Asn Glu Lys Thr Leu Thr 
    370                 375                 380                 


Leu Lys Ser Val Arg Gln Glu Asp Ala Gly Lys Tyr Val Cys Arg Ala 
385                 390                 395                 400 


Val Val Pro Arg Val Gly Ala Gly Glu Arg Glu Val Thr Leu Thr Val 
                405                 410                 415     


Asn Gly Pro Pro Ile Ile Ser Ser Thr Gln Thr Gln His Ala Leu His 
            420                 425                 430         


Gly Glu Lys Gly Gln Ile Lys Cys Phe Ile Arg Ser Thr Pro Pro Pro 
        435                 440                 445             


Asp Arg Ile Ala Trp Ser Trp Lys Glu Asn Val Leu Glu Ser Gly Thr 
    450                 455                 460                 


Ser Gly Arg Tyr Thr Val Glu Thr Ile Ser Thr Glu Glu Gly Val Ile 
465                 470                 475                 480 


Ser Thr Leu Thr Ile Ser Asn Ile Val Arg Ala Asp Phe Gln Thr Ile 
                485                 490                 495     


Tyr Asn Cys Thr Ala Trp Asn Ser Phe Gly Ser Asp Thr Glu Ile Ile 
            500                 505                 510         


Arg Leu Lys Glu Gln Gly Ser Glu Met Lys Ser Gly Ala Gly Leu Glu 
        515                 520                 525             


Ala Glu Ser Val Pro Met Ala Val Ile Ile Gly Val Ala Val Gly Ala 
    530                 535                 540                 


Gly Val Ala Phe Leu Val Leu Met Ala Thr Ile Val Ala Phe Cys Cys 
545                 550                 555                 560 


Ala Arg Ser Gln Arg Ser Thr Gly Gly Arg Ser Gly Ile Ser Gly Arg 
                565                 570                 575     


Gly Thr Glu Lys Lys Ala Arg Leu Arg Leu Pro Arg Arg Ala Ser Lys 
            580                 585                 590         


Gln Glu Cys Asn Glu Gln Gly Ser 
        595                 600 


<210>  2023
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  2023

Met Lys Thr Leu Leu Leu Leu Ala Val Ile Met Ile Phe Gly Leu Leu 
1               5                   10                  15      


Gln Ala His Gly Asn Leu Val Asn Phe His Arg Met Ile Lys Leu Thr 
            20                  25                  30          


Thr Gly Lys Glu Ala Ala Leu Ser Tyr Gly Phe Tyr Gly Cys His Cys 
        35                  40                  45              


Gly Val Gly Gly Arg Gly Ser Pro Lys Asp Ala Thr Asp Arg Cys Cys 
    50                  55                  60                  


Val Thr His Asp Cys Cys Tyr Lys Arg Leu Glu Lys Arg Gly Cys Gly 
65                  70                  75                  80  


Thr Lys Phe Leu Ser Tyr Lys Phe Ser Asn Ser Gly Ser Arg Ile Thr 
                85                  90                  95      


Cys Ala Lys Gln Asp Ser Cys Arg Ser Gln Leu Cys Glu Cys Asp Lys 
            100                 105                 110         


Ala Ala Ala Thr Cys Phe Ala Arg Asn Lys Thr Thr Tyr Asn Lys Lys 
        115                 120                 125             


Tyr Gln Tyr Tyr Ser Asn Lys His Cys Arg Gly Ser Thr Pro Arg Cys 
    130                 135                 140                 


<210>  2024
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  2024

Met Lys Thr Leu Leu Leu Leu Ala Val Ile Met Ile Phe Gly Leu Leu 
1               5                   10                  15      


Gln Ala His Gly Asn Leu Val Asn Phe His Arg Met Ile Lys Leu Thr 
            20                  25                  30          


Thr Gly Lys Glu Ala Ala Leu Ser Tyr Gly Phe Tyr Gly Cys His Cys 
        35                  40                  45              


Gly Val Gly Gly Arg Gly Ser Pro Lys Asp Ala Thr Asp Arg Cys Cys 
    50                  55                  60                  


Val Thr His Asp Cys Cys Tyr Lys Arg Leu Glu Lys Arg Gly Cys Gly 
65                  70                  75                  80  


Thr Lys Phe Leu Ser Tyr Lys Phe Ser Asn Ser Gly Ser Arg Ile Thr 
                85                  90                  95      


Cys Ala Lys Gln Asp Ser Cys Arg Ser Gln Leu Cys Glu Cys Asp Lys 
            100                 105                 110         


Ala Ala Ala Thr Cys Phe Ala Arg Asn Lys Thr Thr Tyr Asn Lys Lys 
        115                 120                 125             


Tyr Gln Tyr Tyr Ser Asn Lys His Cys Arg Gly Ser Thr Pro Arg Cys 
    130                 135                 140                 


<210>  2025
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  2025

Met Lys Thr Leu Leu Leu Leu Ala Val Ile Met Ile Phe Gly Leu Leu 
1               5                   10                  15      


Gln Ala His Gly Asn Leu Val Asn Phe His Arg Met Ile Lys Leu Thr 
            20                  25                  30          


Thr Gly Lys Glu Ala Ala Leu Ser Tyr Gly Phe Tyr Gly Cys His Cys 
        35                  40                  45              


Gly Val Gly Gly Arg Gly Ser Pro Lys Asp Ala Thr Asp Arg Cys Cys 
    50                  55                  60                  


Val Thr His Asp Cys Cys Tyr Lys Arg Leu Glu Lys Arg Gly Cys Gly 
65                  70                  75                  80  


Thr Lys Phe Leu Ser Tyr Lys Phe Ser Asn Ser Gly Ser Arg Ile Thr 
                85                  90                  95      


Cys Ala Lys Gln Asp Ser Cys Arg Ser Gln Leu Cys Glu Cys Asp Lys 
            100                 105                 110         


Ala Ala Ala Thr Cys Phe Ala Arg Asn Lys Thr Thr Tyr Asn Lys Lys 
        115                 120                 125             


Tyr Gln Tyr Tyr Ser Asn Lys His Cys Arg Gly Ser Thr Pro Arg Cys 
    130                 135                 140                 


<210>  2026
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  2026

Met Tyr Ser Phe Met Gly Gly Gly Leu Phe Cys Ala Trp Val Gly Thr 
1               5                   10                  15      


Ile Leu Leu Val Val Ala Met Ala Thr Asp His Trp Met Gln Tyr Arg 
            20                  25                  30          


Leu Ser Gly Ser Phe Ala His Gln Gly Leu Trp Arg Tyr Cys Leu Gly 
        35                  40                  45              


Asn Lys Cys Tyr Leu Gln Thr Asp Ser Ile Ala Tyr Trp Asn Ala Thr 
    50                  55                  60                  


Arg Ala Phe Met Ile Leu Ser Ala Leu Cys Ala Ile Ser Gly Ile Ile 
65                  70                  75                  80  


Met Gly Ile Met Ala Phe Ala His Gln Pro Thr Phe Ser Arg Ile Ser 
                85                  90                  95      


Arg Pro Phe Ser Ala Gly Ile Met Phe Phe Ser Ser Thr Leu Phe Val 
            100                 105                 110         


Val Leu Ala Leu Ala Ile Tyr Thr Gly Val Thr Val Ser Phe Leu Gly 
        115                 120                 125             


Arg Arg Phe Gly Asp Trp Arg Phe Ser Trp Ser Tyr Ile Leu Gly Trp 
    130                 135                 140                 


Val Ala Val Leu Met Thr Phe Phe Ala Gly Ile Phe Tyr Met Cys Ala 
145                 150                 155                 160 


Tyr Arg Val His Glu Cys Arg Arg Leu Ser Thr Pro Arg 
                165                 170             


<210>  2027
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  2027

Met His Arg Ser Phe Leu Gln Ala Arg Arg Ser Arg Asn Thr Thr Arg 
1               5                   10                  15      


Pro Ala Leu Leu Arg Leu Ser Asp Tyr Leu Leu Thr Asn Tyr Arg Lys 
            20                  25                  30          


Gly Val Arg Pro Val Arg Asp Trp Arg Lys Pro Thr Thr Val Ser Ile 
        35                  40                  45              


Asp Val Ile Val Tyr Ala Ile Leu Asn Val Asp Glu Lys Asn Gln Val 
    50                  55                  60                  


Leu Thr Thr Tyr Ile Trp Tyr Arg Gln Tyr Trp Thr Asp Glu Phe Leu 
65                  70                  75                  80  


Gln Trp Asn Pro Glu Asp Phe Asp Asn Ile Thr Lys Leu Ser Ile Pro 
                85                  90                  95      


Thr Asp Ser Ile Trp Val Pro Asp Ile Leu Ile Asn Glu Phe Val Asp 
            100                 105                 110         


Val Gly Lys Ser Pro Asn Ile Pro Tyr Val Tyr Ile Arg His Gln Gly 
        115                 120                 125             


Glu Val Gln Asn Tyr Lys Pro Leu Gln Val Val Thr Ala Cys Ser Leu 
    130                 135                 140                 


Asp Ile Tyr Asn Phe Pro Phe Asp Val Gln Asn Cys Ser Leu Thr Phe 
145                 150                 155                 160 


Thr Ser Trp Leu His Thr Ile Gln Asp Ile Asn Ile Ser Leu Trp Arg 
                165                 170                 175     


Leu Pro Glu Lys Val Lys Ser Asp Arg Ser Val Phe Met Asn Gln Gly 
            180                 185                 190         


Glu Trp Glu Leu Leu Gly Val Leu Pro Tyr Phe Arg Glu Phe Ser Met 
        195                 200                 205             


Glu Ser Ser Asn Tyr Tyr Ala Glu Met Lys Phe Tyr Val Val Ile Arg 
    210                 215                 220                 


Arg Arg Pro Leu Phe Tyr Val Val Ser Leu Leu Leu Pro Ser Ile Phe 
225                 230                 235                 240 


Leu Met Val Met Asp Ile Val Gly Phe Tyr Leu Pro Pro Asn Ser Gly 
                245                 250                 255     


Glu Arg Val Ser Phe Lys Ile Thr Leu Leu Leu Gly Tyr Ser Val Phe 
            260                 265                 270         


Leu Ile Ile Val Ser Asp Thr Leu Pro Ala Thr Ala Ile Gly Thr Pro 
        275                 280                 285             


Leu Ile Gly Val Tyr Phe Val Val Cys Met Ala Leu Leu Val Ile Ser 
    290                 295                 300                 


Leu Ala Glu Thr Ile Phe Ile Val Arg Leu Val His Lys Gln Asp Leu 
305                 310                 315                 320 


Gln Gln Pro Val Pro Ala Trp Leu Arg His Leu Val Leu Glu Arg Ile 
                325                 330                 335     


Ala Trp Leu Leu Cys Leu Arg Glu Gln Ser Thr Ser Gln Arg Pro Pro 
            340                 345                 350         


Ala Thr Ser Gln Ala Thr Lys Thr Asp Asp Cys Ser Ala Met Gly Asn 
        355                 360                 365             


His Cys Ser His Met Gly Gly Pro Gln Asp Phe Glu Lys Ser Pro Arg 
    370                 375                 380                 


Asp Arg Cys Ser Pro Pro Pro Pro Pro Arg Glu Ala Ser Leu Ala Val 
385                 390                 395                 400 


Cys Gly Leu Leu Gln Glu Leu Ser Ser Ile Arg Gln Phe Leu Glu Lys 
                405                 410                 415     


Arg Asp Glu Ile Arg Glu Val Ala Arg Asp Trp Leu Arg Val Gly Ser 
            420                 425                 430         


Val Leu Asp Lys Leu Leu Phe His Ile Tyr Leu Leu Ala Val Leu Ala 
        435                 440                 445             


Tyr Ser Ile Thr Leu Val Met Leu Trp Ser Ile Trp Gln Tyr Ala 
    450                 455                 460             


<210>  2028
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  2028

Met Arg Arg Ala Gly Leu Gly Glu Gly Val Pro Pro Gly Asn Tyr Gly 
1               5                   10                  15      


Asn Tyr Gly Tyr Ala Asn Ser Gly Tyr Ser Ala Cys Glu Glu Glu Asn 
            20                  25                  30          


Glu Arg Leu Thr Glu Ser Leu Arg Ser Lys Val Thr Ala Ile Lys Ser 
        35                  40                  45              


Leu Ser Ile Glu Ile Gly His Glu Val Lys Thr Gln Asn Lys Leu Leu 
    50                  55                  60                  


Ala Glu Met Asp Ser Gln Phe Asp Ser Thr Thr Gly Phe Leu Gly Leu 
65                  70                  75                  80  


Cys Pro Met 
            


<210>  2029
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  2029

Met Glu Asp Tyr Ala Leu Thr Phe Gly Ile Asn Pro Phe Ile Ala Leu 
1               5                   10                  15      


Met Ile Gln Pro Ile Val Thr Met Thr Val Val Asp Asn Gln Gly Leu 
            20                  25                  30          


Gly Leu Pro Val Asp Ile Gln His Lys Ala Lys Pro Ser Pro Lys Ala 
        35                  40                  45              


Ser Gln Met Leu Pro Pro Asp Leu Gly Pro Pro Ser Phe Gln Asn Cys 
    50                  55                  60                  


Phe Thr Cys Arg Thr Ala Pro Ser Leu Val Met Val Leu Ser Trp Lys 
65                  70                  75                  80  


Ser Gly Val Arg Arg Glu Val Pro Val His Pro Ser Tyr Ala Lys Tyr 
                85                  90                  95      


<210>  2030
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  2030

Met Val Ser Val Asn Ser Ser His Cys Phe Tyr Asn Asp Ser Phe Lys 
1               5                   10                  15      


Tyr Thr Leu Tyr Gly Cys Met Phe Ser Met Val Phe Val Leu Gly Leu 
            20                  25                  30          


Ile Ser Asn Cys Val Ala Ile Tyr Ile Phe Ile Cys Val Leu Lys Val 
        35                  40                  45              


Arg Asn Glu Thr Thr Thr Tyr Met Ile Asn Leu Ala Met Ser Asp Leu 
    50                  55                  60                  


Leu Phe Val Phe Thr Leu Pro Phe Arg Ile Phe Tyr Phe Thr Thr Arg 
65                  70                  75                  80  


Asn Trp Pro Phe Gly Asp Leu Leu Cys Lys Ile Ser Val Met Leu Phe 
                85                  90                  95      


Tyr Thr Asn Met Tyr Gly Ser Ile Leu Phe Leu Thr Cys Ile Ser Val 
            100                 105                 110         


Asp Arg Phe Leu Ala Ile Val Tyr Pro Phe Lys Ser Lys Thr Leu Arg 
        115                 120                 125             


Thr Lys Arg Asn Ala Lys Ile Val Cys Thr Gly Val Trp Leu Thr Val 
    130                 135                 140                 


Ile Gly Gly Ser Ala Pro Ala Val Phe Val Gln Ser Thr His Ser Gln 
145                 150                 155                 160 


Gly Asn Asn Ala Ser Glu Ala Cys Phe Glu Asn Phe Pro Glu Ala Thr 
                165                 170                 175     


Trp Lys Thr Tyr Leu Ser Arg Ile Val Ile Phe Ile Glu Ile Val Gly 
            180                 185                 190         


Phe Phe Ile Pro Leu Ile Leu Asn Val Thr Cys Ser Ser Met Val Leu 
        195                 200                 205             


Lys Thr Leu Thr Lys Pro Val Thr Leu Ser Arg Ser Lys Ile Asn Lys 
    210                 215                 220                 


Thr Lys Val Leu Lys Met Ile Phe Val His Leu Ile Ile Phe Cys Phe 
225                 230                 235                 240 


Cys Phe Val Pro Tyr Asn Ile Asn Leu Ile Leu Tyr Ser Leu Val Arg 
                245                 250                 255     


Thr Gln Thr Phe Val Asn Cys Ser Val Val Ala Ala Val Arg Thr Met 
            260                 265                 270         


Tyr Pro Ile Thr Leu Cys Ile Ala Val Ser Asn Cys Cys Phe Asp Pro 
        275                 280                 285             


Ile Val Tyr Tyr Phe Thr Ser Asp Thr Ile Gln Asn Ser Ile Lys Met 
    290                 295                 300                 


Lys Asn Trp Ser Val Arg Arg Ser Asp Phe Arg Phe Ser Glu Val His 
305                 310                 315                 320 


Gly Ala Glu Asn Phe Ile Gln His Asn Leu Gln Thr Leu Lys Ser Lys 
                325                 330                 335     


Ile Phe Asp Asn Glu Ser Ala Ala 
            340                 


<210>  2031
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  2031

Met Val Ser Val Asn Ser Ser His Cys Phe Tyr Asn Asp Ser Phe Lys 
1               5                   10                  15      


Tyr Thr Leu Tyr Gly Cys Met Phe Ser Met Val Phe Val Leu Gly Leu 
            20                  25                  30          


Ile Ser Asn Cys Val Ala Ile Tyr Ile Phe Ile Cys Val Leu Lys Val 
        35                  40                  45              


Arg Asn Glu Thr Thr Thr Tyr Met Ile Asn Leu Ala Met Ser Asp Leu 
    50                  55                  60                  


Leu Phe Val Phe Thr Leu Pro Phe Arg Ile Phe Tyr Phe Thr Thr Arg 
65                  70                  75                  80  


Asn Trp Pro Phe Gly Asp Leu Leu Cys Lys Ile Ser Val Met Leu Phe 
                85                  90                  95      


Tyr Thr Asn Met Tyr Gly Ser Ile Leu Phe Leu Thr Cys Ile Ser Val 
            100                 105                 110         


Asp Arg Phe Leu Ala Ile Val Tyr Pro Phe Lys Ser Lys Thr Leu Arg 
        115                 120                 125             


Thr Lys Arg Asn Ala Lys Ile Val Cys Thr Gly Val Trp Leu Thr Val 
    130                 135                 140                 


Ile Gly Gly Ser Ala Pro Ala Val Phe Val Gln Ser Thr His Ser Gln 
145                 150                 155                 160 


Gly Asn Asn Ala Ser Glu Ala Cys Phe Glu Asn Phe Pro Glu Ala Thr 
                165                 170                 175     


Trp Lys Thr Tyr Leu Ser Arg Ile Val Ile Phe Ile Glu Ile Val Gly 
            180                 185                 190         


Phe Phe Ile Pro Leu Ile Leu Asn Val Thr Cys Ser Ser Met Val Leu 
        195                 200                 205             


Lys Thr Leu Thr Lys Pro Val Thr Leu Ser Arg Ser Lys Ile Asn Lys 
    210                 215                 220                 


Thr Lys Val Leu Lys Met Ile Phe Val His Leu Ile Ile Phe Cys Phe 
225                 230                 235                 240 


Cys Phe Val Pro Tyr Asn Ile Asn Leu Ile Leu Tyr Ser Leu Val Arg 
                245                 250                 255     


Thr Gln Thr Phe Val Asn Cys Ser Val Val Ala Ala Val Arg Thr Met 
            260                 265                 270         


Tyr Pro Ile Thr Leu Cys Ile Ala Val Ser Asn Cys Cys Phe Asp Pro 
        275                 280                 285             


Ile Val Tyr Tyr Phe Thr Ser Asp Thr Ile Gln Asn Ser Ile Lys Met 
    290                 295                 300                 


Lys Asn Trp Ser Val Arg Arg Ser Asp Phe Arg Phe Ser Glu Val His 
305                 310                 315                 320 


Gly Ala Glu Asn Phe Ile Gln His Asn Leu Gln Thr Leu Lys Ser Lys 
                325                 330                 335     


Ile Phe Asp Asn Glu Ser Ala Ala 
            340                 


<210>  2032
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  2032

Met Ala Gly Ala Glu Asp Trp Pro Gly Gln Gln Leu Glu Leu Asp Glu 
1               5                   10                  15      


Asp Glu Ala Ser Cys Cys Arg Trp Gly Ala Gln His Ala Gly Ala Arg 
            20                  25                  30          


Glu Leu Ala Ala Leu Tyr Ser Pro Gly Lys Arg Leu Gln Glu Trp Cys 
        35                  40                  45              


Ser Val Ile Leu Cys Phe Ser Leu Ile Ala His Asn Leu Val His Leu 
    50                  55                  60                  


Leu Leu Leu Ala Arg Trp Glu Asp Thr Pro Leu Val Ile Leu Gly Val 
65                  70                  75                  80  


Val Ala Gly Ala Leu Ile Ala Asp Phe Leu Ser Gly Leu Val His Trp 
                85                  90                  95      


Gly Ala Asp Thr Trp Gly Ser Val Glu Leu Pro Ile Ala Phe Ile Arg 
            100                 105                 110         


Pro Phe Arg Glu His His Ile Asp Pro Thr Ala Ile Thr Arg His Asp 
        115                 120                 125             


Phe Ile Glu Thr Asn Gly Asp Asn Cys Leu Val Thr Leu Leu Pro Leu 
    130                 135                 140                 


Leu Asn Met Ala Tyr Lys Phe Arg Thr His Ser Pro Glu Ala Leu Glu 
145                 150                 155                 160 


Gln Leu Tyr Pro Trp Glu Cys Phe Val Phe Cys Leu Ile Ile Phe Gly 
                165                 170                 175     


Thr Phe Thr Asn Gln Ile His Lys Trp Ser His Thr Tyr Phe Gly Leu 
            180                 185                 190         


Pro Arg Trp Val Thr Leu Leu Gln Asp Trp His Val Ile Leu Pro Arg 
        195                 200                 205             


Lys His His Arg Ile His His Val Ser Pro His Glu Thr Tyr Phe Cys 
    210                 215                 220                 


Ile Thr Thr Gly Trp Leu Asn Tyr Pro Leu Glu Lys Ile Gly Phe Trp 
225                 230                 235                 240 


Arg Arg Leu Glu Asp Leu Ile Gln Gly Leu Thr Gly Glu Lys Pro Arg 
                245                 250                 255     


Ala Asp Asp Met Lys Trp Ala Gln Lys Ile Lys 
            260                 265         


<210>  2033
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  2033

Met Gly Gly Leu Trp Arg Pro Gly Trp Arg Cys Val Pro Phe Cys Gly 
1               5                   10                  15      


Trp Arg Trp Ile His Pro Gly Ser Pro Thr Arg Ala Ala Glu Arg Val 
            20                  25                  30          


Glu Pro Phe Leu Arg Pro Glu Trp Ser Gly Thr Gly Gly Ala Glu Arg 
        35                  40                  45              


Gly Leu Arg Trp Leu Gly Thr Trp Lys Arg Cys Ser Leu Arg Ala Arg 
    50                  55                  60                  


His Pro Ala Leu Gln Pro Pro Arg Arg Pro Lys Ser Ser Asn Pro Phe 
65                  70                  75                  80  


Thr Arg Ala Gln Glu Glu Glu Arg Arg Arg Gln Asn Lys Thr Thr Leu 
                85                  90                  95      


Thr Tyr Val Ala Ala Val Ala Val Gly Met Leu Gly Ala Ser Tyr Ala 
            100                 105                 110         


Ala Val Pro Leu Tyr Arg Leu Tyr Cys Gln Thr Thr Gly Leu Gly Gly 
        115                 120                 125             


Ser Ala Val Ala Gly His Ala Ser Asp Lys Ile Glu Asn Met Val Pro 
    130                 135                 140                 


Val Lys Asp Arg Ile Ile Lys Ile Ser Phe Asn Ala Asp Val His Ala 
145                 150                 155                 160 


Ser Leu Gln Trp Asn Phe Arg Pro Gln Gln Thr Glu Ile Tyr Val Val 
                165                 170                 175     


Pro Gly Glu Thr Ala Leu Ala Phe Tyr Arg Ala Lys Asn Pro Thr Asp 
            180                 185                 190         


Lys Pro Val Ile Gly Ile Ser Thr Tyr Asn Ile Val Pro Phe Glu Ala 
        195                 200                 205             


Gly Gln Tyr Phe Asn Lys Ile Gln Val Leu Ser Ser Arg Leu Gln Ser 
    210                 215                 220                 


Cys Thr Glu Ser Thr Phe 
225                 230 


<210>  2034
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  2034

Met Gly Gly Leu Trp Arg Pro Gly Trp Arg Cys Val Pro Phe Cys Gly 
1               5                   10                  15      


Trp Arg Trp Ile His Pro Gly Ser Pro Thr Arg Ala Ala Glu Arg Val 
            20                  25                  30          


Glu Pro Phe Leu Arg Pro Glu Trp Ser Gly Thr Gly Gly Ala Glu Arg 
        35                  40                  45              


Gly Leu Arg Trp Leu Gly Thr Trp Lys Arg Cys Ser Leu Arg Ala Arg 
    50                  55                  60                  


His Pro Ala Leu Gln Pro Pro Arg Arg Pro Lys Ser Ser Asn Pro Phe 
65                  70                  75                  80  


Thr Arg Ala Gln Glu Glu Glu Arg Arg Arg Gln Asn Lys Thr Thr Leu 
                85                  90                  95      


Thr Tyr Val Ala Ala Val Ala Val Gly Met Leu Gly Ala Ser Tyr Ala 
            100                 105                 110         


Ala Val Pro Leu Tyr Arg Leu Tyr Cys Gln Thr Thr Gly Leu Gly Gly 
        115                 120                 125             


Ser Ala Val Ala Gly His Ala Ser Asp Lys Ile Glu Asn Met Val Pro 
    130                 135                 140                 


Val Lys Asp Arg Ile Ile Lys Ile Ser Phe Asn Ala Asp Val His Ala 
145                 150                 155                 160 


Ser Leu Gln Trp Asn Phe Arg Pro Gln Gln Thr Glu Ile Tyr Val Val 
                165                 170                 175     


Pro Gly Glu Thr Ala Leu Ala Phe Tyr Arg Ala Lys Asn Pro Thr Asp 
            180                 185                 190         


Lys Pro Val Ile Gly Ile Ser Thr Tyr Asn Ile Val Pro Phe Glu Ala 
        195                 200                 205             


Gly Gln Tyr Phe Asn Lys Ile Gln Ala Ser Lys Leu His Arg Val Tyr 
    210                 215                 220                 


Val Leu Glu Ser Trp His Leu 
225                 230     


<210>  2035
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  2035

Met Glu Arg Ile Ser Ala Phe Phe Ser Ser Ile Trp Asp Thr Ile Leu 
1               5                   10                  15      


Thr Lys His Gln Glu Gly Ile Tyr Asn Thr Ile Cys Leu Gly Val Leu 
            20                  25                  30          


Leu Gly Leu Pro Leu Leu Val Ile Ile Thr Leu Leu Phe Ile Cys Cys 
        35                  40                  45              


His Cys Cys Trp Ser Pro Pro Gly Lys Arg Gly Gln Gln Pro Glu Lys 
    50                  55                  60                  


Asn Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Asp Glu Glu Asp Leu 
65                  70                  75                  80  


Trp Ile Ser Ala Gln Pro Lys Leu Leu Gln Met Glu Lys Arg Pro Ser 
                85                  90                  95      


Leu Pro Val 
            


<210>  2036
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  2036

Met Glu Arg Ile Ser Ala Phe Phe Ser Ser Ile Trp Asp Thr Ile Leu 
1               5                   10                  15      


Thr Lys His Gln Glu Gly Ile Tyr Asn Thr Ile Cys Leu Gly Val Leu 
            20                  25                  30          


Leu Gly Leu Pro Leu Leu Val Ile Ile Thr Leu Leu Phe Ile Cys Cys 
        35                  40                  45              


His Cys Cys Trp Ser Pro Pro Gly Lys Arg Gly Gln Gln Pro Glu Lys 
    50                  55                  60                  


Asn Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Asp Glu Glu Asp Leu 
65                  70                  75                  80  


Trp Ile Ser Ala Gln Pro Lys Leu Leu Gln Met Glu Lys Arg Pro Ser 
                85                  90                  95      


Leu Pro Val 
            


<210>  2037
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  2037

Met Glu Arg Ile Ser Ala Phe Phe Ser Ser Ile Trp Asp Thr Ile Leu 
1               5                   10                  15      


Thr Lys His Gln Glu Gly Ile Tyr Asn Thr Ile Cys Leu Gly Val Leu 
            20                  25                  30          


Leu Gly Leu Pro Leu Leu Val Ile Ile Thr Leu Leu Phe Ile Cys Cys 
        35                  40                  45              


His Cys Cys Trp Ser Pro Pro Gly Lys Arg Gly Gln Gln Pro Glu Lys 
    50                  55                  60                  


Asn Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Asp Glu Glu Asp Leu 
65                  70                  75                  80  


Trp Ile Ser Ala Gln Pro Lys Leu Leu Gln Met Glu Lys Arg Pro Ser 
                85                  90                  95      


Leu Pro Val 
            


<210>  2038
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  2038

Met Lys Gln Gln Gln Trp Cys Gly Met Thr Ala Lys Met Gly Thr Val 
1               5                   10                  15      


Leu Ser Gly Val Phe Thr Ile Met Ala Val Asp Met Tyr Leu Ile Phe 
            20                  25                  30          


Glu Gln Lys His Leu Gly Asn Gly Ser Cys Thr Glu Ile Thr Pro Lys 
        35                  40                  45              


Tyr Arg Gly Ala Ser Asn Ile Ile Asn Asn Phe Ile Ile Cys Trp Ser 
    50                  55                  60                  


Phe Lys Ile Val Leu Phe Leu Ser Phe Ile Thr Ile Leu Ile Ser Cys 
65                  70                  75                  80  


Phe Leu Leu Tyr Ser Val Tyr Ala Gln Ile Phe Arg Gly Leu Val Ile 
                85                  90                  95      


Tyr Ile Val Trp Ile Phe Phe Tyr Glu Thr Ala Asn Val Val Ile Gln 
            100                 105                 110         


Ile Leu Thr Asn Asn Asp Phe Asp Ile Lys Glu Val Arg Ile Met Arg 
        115                 120                 125             


Trp Phe Gly Leu Val Ser Arg Thr Val Met His Cys Phe Trp Met Phe 
    130                 135                 140                 


Phe Val Ile Asn Tyr Ala His Ile Thr Tyr Lys Asn Arg Ser Gln Gly 
145                 150                 155                 160 


Asn Ile Ile Ser Tyr Lys Arg Arg Ile Ser Thr Ala Glu Ile Leu His 
                165                 170                 175     


Ser Arg Asn Lys Arg Leu Ser Ile Ser Ser Gly Phe Ser Gly Ser His 
            180                 185                 190         


Leu Glu Ser Gln Tyr Phe Glu Arg Gln Arg 
        195                 200         


<210>  2039
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  2039

Met Ala Ala Thr Asp Phe Val Gln Glu Met Arg Ala Val Gly Glu Arg 
1               5                   10                  15      


Leu Leu Leu Lys Leu Gln Arg Leu Pro Gln Ala Glu Pro Val Glu Ile 
            20                  25                  30          


Val Ala Phe Ser Val Ile Ile Leu Phe Thr Ala Thr Val Leu Leu Leu 
        35                  40                  45              


Leu Leu Ile Ala Cys Ser Cys Cys Cys Thr His Cys Cys Cys Pro Glu 
    50                  55                  60                  


Arg Arg Gly Arg Lys Val Gln Val Gln Pro Thr Pro Pro 
65                  70                  75          


<210>  2040
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  2040

Met Asp Gln Leu Val Phe Lys Glu Thr Ile Trp Asn Asp Ala Phe Trp 
1               5                   10                  15      


Gln Asn Pro Trp Asp Gln Gly Gly Leu Ala Val Ile Ile Leu Phe Ile 
            20                  25                  30          


Thr Ala Val Leu Leu Leu Ile Leu Phe Ala Ile Val Phe Gly Leu Leu 
        35                  40                  45              


Thr Ser Thr Glu Asn Thr Gln Cys Glu Ala Gly Glu Glu Glu 
    50                  55                  60          


<210>  2041
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  2041

Met Ala Leu Ser Val Pro Leu Leu Tyr Ser Leu Val Arg Ala Ile Ser 
1               5                   10                  15      


Glu Ala Gly Ala Pro Pro Gly Ser Ala Gly Pro Leu Leu Leu Gln Pro 
            20                  25                  30          


Gln Arg His Arg Ala Ala Gly Cys Phe Leu Gly Thr Cys Leu Asp Leu 
        35                  40                  45              


Leu Asp Ser Phe Thr Leu Val Glu Leu Met Leu Glu Gly Arg Val Pro 
    50                  55                  60                  


Leu Pro Ala His Leu Arg Tyr Leu Leu Ile Ala Val Tyr Phe Leu Thr 
65                  70                  75                  80  


Leu Ala Ser Pro Val Leu Trp Leu Tyr Glu Leu Asn Ala Ala Ala Ala 
                85                  90                  95      


Ala Ala Ala Ser Trp Gly Gln Ala Ser Gly Pro Gly Ser Cys Ser Arg 
            100                 105                 110         


Leu Leu Arg Leu Leu Gly Gly Cys Leu Val Asp Val Pro Leu Leu Ala 
        115                 120                 125             


Leu Arg Cys Leu Leu Val Val Ser Tyr Gln Gln Pro Leu Ser Ile Phe 
    130                 135                 140                 


Met Leu Lys Asn Leu Phe Phe Leu Gly Cys Arg Gly Leu Glu Ala Leu 
145                 150                 155                 160 


Glu Gly Cys Trp Asp Arg Gly Asn Arg Ala Ser Pro Ser Arg Ala Arg 
                165                 170                 175     


Gly Gly Tyr Gly Ala Pro Pro Ser Ala Pro Pro Pro Pro Pro Pro Pro 
            180                 185                 190         


Pro Gln Gly Gly Ser Gln Leu Gly His Cys Ile Ser Glu Asn Glu Gly 
        195                 200                 205             


Gly Ala His Gly Tyr Val Asn Thr Leu Ala Val Ala Ser Gln Asn 
    210                 215                 220             


<210>  2042
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  2042

Met Ala Glu Leu Val Pro Phe Ala Val Pro Ile Glu Ser Asp Lys Thr 
1               5                   10                  15      


Leu Leu Val Trp Glu Leu Ser Ser Gly Pro Thr Ala Glu Ala Leu His 
            20                  25                  30          


His Ser Leu Phe Thr Ala Phe Ser Gln Phe Gly Leu Leu Tyr Ser Val 
        35                  40                  45              


Arg Val Phe Pro Asn Ala Ala Val Ala His Pro Gly Phe Tyr Ala Val 
    50                  55                  60                  


Ile Lys Phe Tyr Ser Ala Arg Ala Ala His Arg Ala Gln Lys Ala Cys 
65                  70                  75                  80  


Asp Arg Lys Gln Leu Phe Gln Lys Ser Pro Val Lys Val Arg Leu Gly 
                85                  90                  95      


Thr Arg His Lys Ala Val Gln His Gln Ala Leu Ala Leu Asn Ser Ser 
            100                 105                 110         


Lys Cys Gln Glu Leu Ala Asn Tyr Tyr Phe Gly Phe Asn Gly Cys Ser 
        115                 120                 125             


Lys Arg Ile Ile Lys Val Pro Cys Ser Pro Trp Lys Gln Tyr Gly Gln 
    130                 135                 140                 


Glu Glu Glu Gly Tyr Leu Ser Asp Phe Ser Leu Glu Glu Glu Glu Phe 
145                 150                 155                 160 


Arg Leu Pro Glu Leu Asp 
                165     


<210>  2043
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  2043

Met Ala Glu Leu Val Pro Phe Ala Val Pro Ile Glu Ser Asp Lys Thr 
1               5                   10                  15      


Leu Leu Val Trp Glu Leu Ser Ser Gly Pro Thr Ala Glu Ala Leu His 
            20                  25                  30          


His Ser Leu Phe Thr Ala Phe Ser Gln Phe Gly Leu Leu Tyr Ser Val 
        35                  40                  45              


Arg Val Phe Pro Asn Ala Ala Val Ala His Pro Gly Phe Tyr Ala Val 
    50                  55                  60                  


Ile Lys Phe Tyr Ser Ala Arg Ala Ala His Arg Ala Gln Lys Ala Cys 
65                  70                  75                  80  


Asp Arg Lys Gln Leu Phe Gln Lys Ser Pro Val Lys Val Arg Leu Gly 
                85                  90                  95      


Thr Arg His Lys Ala Val Gln His Gln Ala Leu Ala Leu Asn Ser Ser 
            100                 105                 110         


Lys Cys Gln Glu Leu Ala Asn Tyr Tyr Phe Gly Phe Asn Gly Cys Ser 
        115                 120                 125             


Lys Arg Ile Ile Lys Leu Gln Glu Leu Ser Asp Leu Glu Glu Arg Glu 
    130                 135                 140                 


Asn Glu Asp Ser Met Val Pro Leu Pro Lys Gln Ser Leu Lys Phe Phe 
145                 150                 155                 160 


Cys Ala Leu Glu Val Val Leu Pro Ser Cys Asp Cys Arg Ser Pro Gly 
                165                 170                 175     


Ile Gly Leu Val Glu Glu Pro Met Asp Lys Val Glu Glu Glu Ser Gly 
            180                 185                 190         


Lys Ile Ala Val Glu Tyr Arg Pro Ser Glu Asp Ile Val Gly Val Arg 
        195                 200                 205             


Cys Glu Glu Glu Leu His Gly Leu Ile Gln Val Pro Cys Ser Pro Trp 
    210                 215                 220                 


Lys Gln Tyr Gly Gln Glu Glu Glu Gly Tyr Leu Ser Asp Phe Ser Leu 
225                 230                 235                 240 


Glu Glu Glu Glu Phe Arg Leu Pro Glu Leu Asp 
                245                 250     


<210>  2044
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  2044

Met His Leu Leu Val Pro Pro Pro Gln His Ser Leu Phe Thr Ala Phe 
1               5                   10                  15      


Ser Gln Phe Gly Leu Leu Tyr Ser Val Arg Val Phe Pro Asn Ala Ala 
            20                  25                  30          


Val Ala His Pro Gly Phe Tyr Ala Val Ile Lys Phe Tyr Ser Ala Arg 
        35                  40                  45              


Ala Ala His Arg Ala Gln Lys Ala Cys Asp Arg Lys Gln Leu Phe Gln 
    50                  55                  60                  


Lys Ser Pro Val Lys Val Arg Leu Gly Thr Arg His Lys Ala Val Gln 
65                  70                  75                  80  


His Gln Ala Leu Ala Leu Asn Ser Ser Lys Cys Gln Glu Leu Ala Asn 
                85                  90                  95      


Tyr Tyr Phe Gly Phe Asn Gly Cys Ser Lys Arg Ile Ile Lys Leu Gln 
            100                 105                 110         


Glu Leu Ser Asp Leu Glu Glu Arg Glu Asn Glu Asp Ser Met Val Pro 
        115                 120                 125             


Leu Pro Lys Gln Ser Leu Lys Phe Phe Cys Ala Leu Glu Val Val Leu 
    130                 135                 140                 


Pro Ser Cys Asp Cys Arg Ser Pro Gly Ile Gly Leu Val Glu Glu Pro 
145                 150                 155                 160 


Met Asp Lys Val Glu Glu Glu Ser Gly Lys Ile Ala Val Glu Tyr Arg 
                165                 170                 175     


Pro Ser Glu Asp Ile Val Gly Val Arg Cys Glu Glu Glu Leu His Gly 
            180                 185                 190         


Leu Ile Gln Val Pro Cys Ser Pro Trp Lys Gln Tyr Gly Gln Glu Glu 
        195                 200                 205             


Glu Gly Tyr Leu Ser Asp Phe Ser Leu Glu Glu Glu Glu Phe Arg Leu 
    210                 215                 220                 


Pro Glu Leu Asp 
225             


<210>  2045
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  2045

Met His Leu Leu Val Pro Pro Pro Gln His Ser Leu Phe Thr Ala Phe 
1               5                   10                  15      


Ser Gln Phe Gly Leu Leu Tyr Ser Val Arg Val Phe Pro Asn Ala Ala 
            20                  25                  30          


Val Ala His Pro Gly Phe Tyr Ala Val Ile Lys Phe Tyr Ser Ala Arg 
        35                  40                  45              


Ala Ala His Arg Ala Gln Lys Ala Cys Asp Arg Lys Gln Leu Phe Gln 
    50                  55                  60                  


Lys Ser Pro Val Lys Val Arg Leu Gly Thr Arg His Lys Ala Val Gln 
65                  70                  75                  80  


His Gln Ala Leu Ala Leu Asn Ser Ser Lys Cys Gln Glu Leu Ala Asn 
                85                  90                  95      


Tyr Tyr Phe Gly Phe Asn Gly Cys Ser Lys Arg Ile Ile Lys Val Pro 
            100                 105                 110         


Cys Ser Pro Trp Lys Gln Tyr Gly Gln Glu Glu Glu Gly Tyr Leu Ser 
        115                 120                 125             


Asp Phe Ser Leu Glu Glu Glu Glu Phe Arg Leu Pro Glu Leu Asp 
    130                 135                 140             


<210>  2046
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  2046

Met His Leu Leu Val Pro Pro Pro Gln His Ser Leu Phe Thr Ala Phe 
1               5                   10                  15      


Ser Gln Phe Gly Leu Leu Tyr Ser Val Arg Val Phe Pro Asn Ala Ala 
            20                  25                  30          


Val Ala His Pro Gly Phe Tyr Ala Val Ile Lys Phe Tyr Ser Ala Arg 
        35                  40                  45              


Ala Ala His Arg Ala Gln Lys Ala Cys Asp Arg Lys Gln Leu Phe Gln 
    50                  55                  60                  


Lys Ser Pro Val Lys Val Arg Leu Gly Thr Arg His Lys Ala Val Gln 
65                  70                  75                  80  


His Gln Ala Leu Ala Leu Asn Ser Ser Lys Cys Gln Glu Leu Ala Asn 
                85                  90                  95      


Tyr Tyr Phe Gly Phe Asn Gly Cys Ser Lys Arg Ile Ile Lys Asp His 
            100                 105                 110         


Tyr His Ser Leu 
        115     


<210>  2047
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  2047

Met His Leu Leu Val Pro Pro Pro Gln His Ser Leu Phe Thr Ala Phe 
1               5                   10                  15      


Ser Gln Phe Gly Leu Leu Tyr Ser Val Arg Val Phe Pro Asn Ala Ala 
            20                  25                  30          


Val Ala His Pro Gly Phe Tyr Ala Val Ile Lys Phe Tyr Ser Ala Arg 
        35                  40                  45              


Ala Ala His Arg Ala Gln Lys Ala Cys Asp Arg Lys Gln Leu Phe Gln 
    50                  55                  60                  


Lys Ser Pro Val Lys Val Arg Leu Gly Thr Arg His Lys Ala Val Gln 
65                  70                  75                  80  


His Gln Ala Leu Ala Leu Asn Ser Ser Lys Cys Gln Glu Leu Ala Asn 
                85                  90                  95      


Tyr Tyr Phe Gly Phe Asn Gly Cys Ser Lys Arg Ile Ile Lys Leu Gln 
            100                 105                 110         


Glu Leu Ser Asp Leu Glu Glu Arg Glu Asn Glu Asp Ser Met Val Pro 
        115                 120                 125             


Leu Pro Lys Gln Ser Leu Lys Phe Phe Cys Ala Leu Glu Val Val Leu 
    130                 135                 140                 


Pro Ser Cys Asp Cys Arg Ser Pro Gly Ile Gly Leu Val Glu Glu Pro 
145                 150                 155                 160 


Met Asp Lys Val Glu Glu Gly Pro Leu Ser Phe Leu Met Lys Arg Lys 
                165                 170                 175     


Thr Ala Gln Lys Leu Ala Ile Gln Lys Ala Leu Ser Asp Ala Phe Gln 
            180                 185                 190         


Lys Leu Leu Ile Val Val Leu Glu Ser Gly Lys Ile Ala Val Glu Tyr 
        195                 200                 205             


Arg Pro Ser Glu Asp Ile Val Gly Val Arg Cys Glu Glu Glu Leu His 
    210                 215                 220                 


Gly Leu Ile Gln Val Pro Cys Ser Pro Trp Lys Gln Tyr Gly Gln Glu 
225                 230                 235                 240 


Glu Glu Gly Tyr Leu Ser Asp Phe Ser Leu Glu Glu Glu Glu Phe Arg 
                245                 250                 255     


Leu Pro Glu Leu Asp 
            260     


<210>  2048
<211>  808
<212>  PRT
<213>  Homo sapiens

<400>  2048

Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile 
1               5                   10                  15      


Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val 
            20                  25                  30          


Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln 
        35                  40                  45              


Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro 
    50                  55                  60                  


Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly 
65                  70                  75                  80  


Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val 
                85                  90                  95      


Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg 
            100                 105                 110         


Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala 
        115                 120                 125             


Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr 
    130                 135                 140                 


Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp 
145                 150                 155                 160 


Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys 
                165                 170                 175     


Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly 
            180                 185                 190         


Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His 
        195                 200                 205             


Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly 
    210                 215                 220                 


Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr 
225                 230                 235                 240 


Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
                245                 250                 255     


Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu 
            260                 265                 270         


Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu 
        275                 280                 285             


Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro 
    290                 295                 300                 


Tyr Val Thr Val Leu Lys Ser Trp Ile Ser Glu Ser Val Glu Ala Asp 
305                 310                 315                 320 


Val Arg Leu Arg Leu Ala Asn Val Ser Glu Arg Asp Gly Gly Glu Tyr 
                325                 330                 335     


Leu Cys Arg Ala Thr Asn Phe Ile Gly Val Ala Glu Lys Ala Phe Trp 
            340                 345                 350         


Leu Ser Val His Gly Pro Arg Ala Ala Glu Glu Glu Leu Val Glu Ala 
        355                 360                 365             


Asp Glu Ala Gly Ser Val Tyr Ala Gly Ile Leu Ser Tyr Gly Val Gly 
    370                 375                 380                 


Phe Phe Leu Phe Ile Leu Val Val Ala Ala Val Thr Leu Cys Arg Leu 
385                 390                 395                 400 


Arg Ser Pro Pro Lys Lys Gly Leu Gly Ser Pro Thr Val His Lys Ile 
                405                 410                 415     


Ser Arg Phe Pro Leu Lys Arg Gln Val Ser Leu Glu Ser Asn Ala Ser 
            420                 425                 430         


Met Ser Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser Ser Gly 
        435                 440                 445             


Glu Gly Pro Thr Leu Ala Asn Val Ser Glu Leu Glu Leu Pro Ala Asp 
    450                 455                 460                 


Pro Lys Trp Glu Leu Ser Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu 
465                 470                 475                 480 


Gly Glu Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile Gly Ile 
                485                 490                 495     


Asp Lys Asp Arg Ala Ala Lys Pro Val Thr Val Ala Val Lys Met Leu 
            500                 505                 510         


Lys Asp Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met 
        515                 520                 525             


Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu 
    530                 535                 540                 


Gly Ala Cys Thr Gln Gly Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala 
545                 550                 555                 560 


Ala Lys Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly 
                565                 570                 575     


Leu Asp Tyr Ser Phe Asp Thr Cys Lys Pro Pro Glu Glu Gln Leu Thr 
            580                 585                 590         


Phe Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu 
        595                 600                 605             


Tyr Leu Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn 
    610                 615                 620                 


Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu 
625                 630                 635                 640 


Ala Arg Asp Val His Asn Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly 
                645                 650                 655     


Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val 
            660                 665                 670         


Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu 
        675                 680                 685             


Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu 
    690                 695                 700                 


Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn 
705                 710                 715                 720 


Cys Thr His Asp Leu Tyr Met Ile Met Arg Glu Cys Trp His Ala Ala 
                725                 730                 735     


Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg 
            740                 745                 750         


Val Leu Thr Val Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser Ala Pro 
        755                 760                 765             


Phe Glu Gln Tyr Ser Pro Gly Gly Gln Asp Thr Pro Ser Ser Ser Ser 
    770                 775                 780                 


Ser Gly Asp Asp Ser Val Phe Ala His Asp Leu Leu Pro Pro Ala Pro 
785                 790                 795                 800 


Pro Ser Ser Gly Gly Ser Arg Thr 
                805             


<210>  2049
<211>  2732
<212>  PRT
<213>  Homo sapiens

<400>  2049

Met Glu Gln Thr Asp Cys Lys Pro Tyr Gln Pro Leu Pro Lys Val Lys 
1               5                   10                  15      


His Glu Met Asp Leu Ala Tyr Thr Ser Ser Ser Asp Glu Ser Glu Asp 
            20                  25                  30          


Gly Arg Lys Pro Arg Gln Ser Tyr Asn Ser Arg Glu Thr Leu His Glu 
        35                  40                  45              


Tyr Asn Gln Glu Leu Arg Met Asn Tyr Asn Ser Gln Ser Arg Lys Arg 
    50                  55                  60                  


Lys Glu Val Glu Lys Ser Thr Gln Glu Met Glu Phe Cys Glu Thr Ser 
65                  70                  75                  80  


His Thr Leu Cys Ser Gly Tyr Gln Thr Asp Met His Ser Val Ser Arg 
                85                  90                  95      


His Gly Tyr Gln Leu Glu Met Gly Ser Asp Val Asp Thr Glu Thr Glu 
            100                 105                 110         


Gly Ala Ala Ser Pro Asp His Ala Leu Arg Met Trp Ile Arg Gly Met 
        115                 120                 125             


Lys Ser Glu His Ser Ser Cys Leu Ser Ser Arg Ala Asn Ser Ala Leu 
    130                 135                 140                 


Ser Leu Thr Asp Thr Asp His Glu Arg Lys Ser Asp Gly Glu Asn Gly 
145                 150                 155                 160 


Phe Lys Phe Ser Pro Val Cys Cys Asp Met Glu Ala Gln Ala Gly Ser 
                165                 170                 175     


Thr Gln Asp Val Gln Ser Ser Pro His Asn Gln Phe Thr Phe Arg Pro 
            180                 185                 190         


Leu Pro Pro Pro Pro Pro Pro Pro His Ala Cys Thr Cys Ala Arg Lys 
        195                 200                 205             


Pro Pro Pro Ala Ala Asp Ser Leu Gln Arg Arg Ser Met Thr Thr Arg 
    210                 215                 220                 


Ser Gln Pro Ser Pro Ala Ala Pro Ala Pro Pro Thr Ser Thr Gln Asp 
225                 230                 235                 240 


Ser Val His Leu His Asn Ser Trp Val Leu Asn Ser Asn Ile Pro Leu 
                245                 250                 255     


Glu Thr Arg His Phe Leu Phe Lys His Gly Ser Gly Ser Ser Ala Ile 
            260                 265                 270         


Phe Ser Ala Ala Ser Gln Asn Tyr Pro Leu Thr Ser Asn Thr Val Tyr 
        275                 280                 285             


Ser Pro Pro Pro Arg Pro Leu Pro Arg Ser Thr Phe Ser Arg Pro Ala 
    290                 295                 300                 


Phe Thr Phe Asn Lys Pro Tyr Arg Cys Cys Asn Trp Lys Cys Thr Ala 
305                 310                 315                 320 


Leu Ser Ala Thr Ala Ile Thr Val Thr Leu Ala Leu Leu Leu Ala Tyr 
                325                 330                 335     


Val Ile Ala Val His Leu Phe Gly Leu Thr Trp Gln Leu Gln Pro Val 
            340                 345                 350         


Glu Gly Glu Leu Tyr Ala Asn Gly Val Ser Lys Gly Asn Arg Gly Thr 
        355                 360                 365             


Glu Ser Met Asp Thr Thr Tyr Ser Pro Ile Gly Gly Lys Val Ser Asp 
    370                 375                 380                 


Lys Ser Glu Lys Lys Val Phe Gln Lys Gly Arg Ala Ile Asp Thr Gly 
385                 390                 395                 400 


Glu Val Asp Ile Gly Ala Gln Val Met Gln Thr Ile Pro Pro Gly Leu 
                405                 410                 415     


Phe Trp Arg Phe Gln Ile Thr Ile His His Pro Ile Tyr Leu Lys Phe 
            420                 425                 430         


Asn Ile Ser Leu Ala Lys Asp Ser Leu Leu Gly Ile Tyr Gly Arg Arg 
        435                 440                 445             


Asn Ile Pro Pro Thr His Thr Gln Phe Asp Phe Val Lys Leu Met Asp 
    450                 455                 460                 


Gly Lys Gln Leu Val Lys Gln Asp Ser Lys Gly Ser Asp Asp Thr Gln 
465                 470                 475                 480 


His Ser Pro Arg Asn Leu Ile Leu Thr Ser Leu Gln Glu Thr Gly Phe 
                485                 490                 495     


Ile Glu Tyr Met Asp Gln Gly Pro Trp Tyr Leu Ala Phe Tyr Asn Asp 
            500                 505                 510         


Gly Lys Lys Met Glu Gln Val Phe Val Leu Thr Thr Ala Ile Glu Ile 
        515                 520                 525             


Met Asp Asp Cys Ser Thr Asn Cys Asn Gly Asn Gly Glu Cys Ile Ser 
    530                 535                 540                 


Gly His Cys His Cys Phe Pro Gly Phe Leu Gly Pro Asp Cys Ala Arg 
545                 550                 555                 560 


Asp Ser Cys Pro Val Leu Cys Gly Gly Asn Gly Glu Tyr Glu Lys Gly 
                565                 570                 575     


His Cys Val Cys Arg His Gly Trp Lys Gly Pro Glu Cys Asp Val Pro 
            580                 585                 590         


Glu Glu Gln Cys Ile Asp Pro Thr Cys Phe Gly His Gly Thr Cys Ile 
        595                 600                 605             


Met Gly Val Cys Ile Cys Val Pro Gly Tyr Lys Gly Glu Ile Cys Glu 
    610                 615                 620                 


Glu Glu Asp Cys Leu Asp Pro Met Cys Ser Asn His Gly Ile Cys Val 
625                 630                 635                 640 


Lys Gly Glu Cys His Cys Ser Thr Gly Trp Gly Gly Val Asn Cys Glu 
                645                 650                 655     


Thr Pro Leu Pro Val Cys Gln Glu Gln Cys Ser Gly His Gly Thr Phe 
            660                 665                 670         


Leu Leu Asp Ala Gly Val Cys Ser Cys Asp Pro Lys Trp Thr Gly Ser 
        675                 680                 685             


Asp Cys Ser Thr Glu Leu Cys Thr Met Glu Cys Gly Ser His Gly Val 
    690                 695                 700                 


Cys Ser Arg Gly Ile Cys Gln Cys Glu Glu Gly Trp Val Gly Pro Thr 
705                 710                 715                 720 


Cys Glu Glu Arg Ser Cys His Ser His Cys Thr Glu His Gly Gln Cys 
                725                 730                 735     


Lys Asp Gly Lys Cys Glu Cys Ser Pro Gly Trp Glu Gly Asp His Cys 
            740                 745                 750         


Thr Ile Ala His Tyr Leu Asp Ala Val Arg Asp Gly Cys Pro Gly Leu 
        755                 760                 765             


Cys Phe Gly Asn Gly Arg Cys Thr Leu Asp Gln Asn Gly Trp His Cys 
    770                 775                 780                 


Val Cys Gln Val Gly Trp Ser Gly Thr Gly Cys Asn Val Val Met Glu 
785                 790                 795                 800 


Met Leu Cys Gly Asp Asn Leu Asp Asn Asp Gly Asp Gly Leu Thr Asp 
                805                 810                 815     


Cys Val Asp Pro Asp Cys Cys Gln Gln Ser Asn Cys Tyr Ile Ser Pro 
            820                 825                 830         


Leu Cys Gln Gly Ser Pro Asp Pro Leu Asp Leu Ile Gln Gln Ser Gln 
        835                 840                 845             


Thr Leu Phe Ser Gln His Thr Ser Arg Leu Phe Tyr Asp Arg Ile Lys 
    850                 855                 860                 


Phe Leu Ile Gly Lys Asp Ser Thr His Val Ile Pro Pro Glu Val Ser 
865                 870                 875                 880 


Phe Asp Ser Arg Arg Ala Cys Val Ile Arg Gly Gln Val Val Ala Ile 
                885                 890                 895     


Asp Gly Thr Pro Leu Val Gly Val Asn Val Ser Phe Leu His His Ser 
            900                 905                 910         


Asp Tyr Gly Phe Thr Ile Ser Arg Gln Asp Gly Ser Phe Asp Leu Val 
        915                 920                 925             


Ala Ile Gly Gly Ile Ser Val Ile Leu Ile Phe Asp Arg Ser Pro Phe 
    930                 935                 940                 


Leu Pro Glu Lys Arg Thr Leu Trp Leu Pro Trp Asn Gln Phe Ile Val 
945                 950                 955                 960 


Val Glu Lys Val Thr Met Gln Arg Val Val Ser Asp Pro Pro Ser Cys 
                965                 970                 975     


Asp Ile Ser Asn Phe Ile Ser Pro Asn Pro Ile Val Leu Pro Ser Pro 
            980                 985                 990         


Leu Thr Ser Phe Gly Gly Ser Cys  Pro Glu Arg Gly Thr  Ile Val Pro 
        995                 1000                 1005             


Glu Leu  Gln Val Val Gln Glu  Glu Ile Pro Ile Pro  Ser Ser Phe 
    1010                 1015                 1020             


Val Arg  Leu Ser Tyr Leu Ser  Ser Arg Thr Pro Gly  Tyr Lys Thr 
    1025                 1030                 1035             


Leu Leu  Arg Ile Leu Leu Thr  His Ser Thr Ile Pro  Val Gly Met 
    1040                 1045                 1050             


Ile Lys  Val His Leu Thr Val  Ala Val Glu Gly Arg  Leu Thr Gln 
    1055                 1060                 1065             


Lys Trp  Phe Pro Ala Ala Ile  Asn Leu Val Tyr Thr  Phe Ala Trp 
    1070                 1075                 1080             


Asn Lys  Thr Asp Ile Tyr Gly  Gln Lys Val Trp Gly  Leu Ala Glu 
    1085                 1090                 1095             


Ala Leu  Val Ser Val Gly Tyr  Glu Tyr Glu Thr Cys  Pro Asp Phe 
    1100                 1105                 1110             


Ile Leu  Trp Glu Gln Arg Thr  Val Val Leu Gln Gly  Phe Glu Met 
    1115                 1120                 1125             


Asp Ala  Ser Asn Leu Gly Gly  Trp Ser Leu Asn Lys  His His Ile 
    1130                 1135                 1140             


Leu Asn  Pro Gln Ser Gly Ile  Ile His Lys Gly Asn  Gly Glu Asn 
    1145                 1150                 1155             


Met Phe  Ile Ser Gln Gln Pro  Pro Val Ile Ser Thr  Ile Met Gly 
    1160                 1165                 1170             


Asn Gly  His Gln Arg Ser Val  Ala Cys Thr Asn Cys  Asn Gly Pro 
    1175                 1180                 1185             


Ala His  Asn Asn Lys Leu Phe  Ala Pro Val Ala Leu  Ala Ser Gly 
    1190                 1195                 1200             


Pro Asp  Gly Ser Val Tyr Val  Gly Asp Phe Asn Phe  Val Arg Arg 
    1205                 1210                 1215             


Ile Phe  Pro Ser Gly Asn Ser  Val Ser Ile Leu Glu  Leu Arg Asn 
    1220                 1225                 1230             


Arg Asp  Thr Arg His Ser Thr  Ser Pro Ala His Lys  Tyr Tyr Leu 
    1235                 1240                 1245             


Ala Met  Asp Pro Val Ser Glu  Ser Leu Tyr Leu Ser  Asp Thr Asn 
    1250                 1255                 1260             


Thr Arg  Lys Val Tyr Lys Leu  Lys Ser Leu Val Glu  Thr Lys Asp 
    1265                 1270                 1275             


Leu Ser  Lys Asn Phe Glu Val  Val Ala Gly Thr Gly  Asp Gln Cys 
    1280                 1285                 1290             


Leu Pro  Phe Asp Gln Ser His  Cys Gly Asp Gly Gly  Arg Ala Ser 
    1295                 1300                 1305             


Glu Ala  Ser Leu Asn Ser Pro  Arg Gly Ile Thr Val  Asp Arg His 
    1310                 1315                 1320             


Gly Phe  Ile Tyr Phe Val Asp  Gly Thr Met Ile Arg  Lys Ile Asp 
    1325                 1330                 1335             


Glu Asn  Ala Val Ile Thr Thr  Val Ile Gly Ser Asn  Gly Leu Thr 
    1340                 1345                 1350             


Ser Thr  Gln Pro Leu Ser Cys  Asp Ser Gly Met Asp  Ile Thr Gln 
    1355                 1360                 1365             


Val Arg  Leu Glu Trp Pro Thr  Asp Leu Ala Val Asn  Pro Met Asp 
    1370                 1375                 1380             


Asn Ser  Leu Tyr Val Leu Asp  Asn Asn Ile Val Leu  Gln Ile Ser 
    1385                 1390                 1395             


Glu Asn  Arg Arg Val Arg Ile  Ile Ala Gly Arg Pro  Ile His Cys 
    1400                 1405                 1410             


Gln Val  Pro Gly Ile Asp His  Phe Leu Val Ser Lys  Val Ala Ile 
    1415                 1420                 1425             


His Ser  Thr Leu Glu Ser Ala  Arg Ala Ile Ser Val  Ser His Ser 
    1430                 1435                 1440             


Gly Leu  Leu Phe Ile Ala Glu  Thr Asp Glu Arg Lys  Val Asn Arg 
    1445                 1450                 1455             


Ile Gln  Gln Val Thr Thr Asn  Gly Glu Ile Tyr Ile  Ile Ala Gly 
    1460                 1465                 1470             


Ala Pro  Thr Asp Cys Asp Cys  Lys Ile Asp Pro Asn  Cys Asp Cys 
    1475                 1480                 1485             


Phe Ser  Gly Asp Gly Gly Tyr  Ala Lys Asp Ala Lys  Met Lys Ala 
    1490                 1495                 1500             


Pro Ser  Ser Leu Ala Val Ser  Pro Asp Gly Thr Leu  Tyr Val Ala 
    1505                 1510                 1515             


Asp Leu  Gly Asn Val Arg Ile  Arg Thr Ile Ser Arg  Asn Gln Ala 
    1520                 1525                 1530             


His Leu  Asn Asp Met Asn Ile  Tyr Glu Ile Ala Ser  Pro Ala Asp 
    1535                 1540                 1545             


Gln Glu  Leu Tyr Gln Phe Thr  Val Asn Gly Thr His  Leu His Thr 
    1550                 1555                 1560             


Leu Asn  Leu Ile Thr Arg Asp  Tyr Val Tyr Asn Phe  Thr Tyr Asn 
    1565                 1570                 1575             


Ser Glu  Gly Asp Leu Gly Ala  Ile Thr Ser Ser Asn  Gly Asn Ser 
    1580                 1585                 1590             


Val His  Ile Arg Arg Asp Ala  Gly Gly Met Pro Leu  Trp Leu Val 
    1595                 1600                 1605             


Val Pro  Gly Gly Gln Val Tyr  Trp Leu Thr Ile Ser  Ser Asn Gly 
    1610                 1615                 1620             


Val Leu  Lys Arg Val Ser Ala  Gln Gly Tyr Asn Leu  Ala Leu Met 
    1625                 1630                 1635             


Thr Tyr  Pro Gly Asn Thr Gly  Leu Leu Ala Thr Lys  Ser Asn Glu 
    1640                 1645                 1650             


Asn Gly  Trp Thr Thr Val Tyr  Glu Tyr Asp Pro Glu  Gly His Leu 
    1655                 1660                 1665             


Thr Asn  Ala Thr Phe Pro Thr  Gly Glu Val Ser Ser  Phe His Ser 
    1670                 1675                 1680             


Asp Leu  Glu Lys Leu Thr Lys  Val Glu Leu Asp Thr  Ser Asn Arg 
    1685                 1690                 1695             


Glu Asn  Val Leu Met Ser Thr  Asn Leu Thr Ala Thr  Ser Thr Ile 
    1700                 1705                 1710             


Tyr Ile  Leu Lys Gln Glu Asn  Thr Gln Ser Thr Tyr  Arg Val Asn 
    1715                 1720                 1725             


Pro Asp  Gly Ser Leu Arg Val  Thr Phe Ala Ser Gly  Met Glu Ile 
    1730                 1735                 1740             


Gly Leu  Ser Ser Glu Pro His  Ile Leu Ala Gly Ala  Val Asn Pro 
    1745                 1750                 1755             


Thr Leu  Gly Lys Cys Asn Ile  Ser Leu Pro Gly Glu  His Asn Ala 
    1760                 1765                 1770             


Asn Leu  Ile Glu Trp Arg Gln  Arg Lys Glu Gln Asn  Lys Gly Asn 
    1775                 1780                 1785             


Val Ser  Ala Phe Glu Arg Arg  Leu Arg Ala His Asn  Arg Asn Leu 
    1790                 1795                 1800             


Leu Ser  Ile Asp Phe Asp His  Ile Thr Arg Thr Gly  Lys Ile Tyr 
    1805                 1810                 1815             


Asp Asp  His Arg Lys Phe Thr  Leu Arg Ile Leu Tyr  Asp Gln Thr 
    1820                 1825                 1830             


Gly Arg  Pro Ile Leu Trp Ser  Pro Val Ser Arg Tyr  Asn Glu Val 
    1835                 1840                 1845             


Asn Ile  Thr Tyr Ser Pro Ser  Gly Leu Val Thr Phe  Ile Gln Arg 
    1850                 1855                 1860             


Gly Thr  Trp Asn Glu Lys Met  Glu Tyr Asp Gln Ser  Gly Lys Ile 
    1865                 1870                 1875             


Ile Ser  Arg Thr Trp Ala Asp  Gly Lys Ile Trp Ser  Tyr Thr Tyr 
    1880                 1885                 1890             


Leu Glu  Lys Ser Val Met Leu  Leu Leu His Ser Gln  Arg Arg Tyr 
    1895                 1900                 1905             


Ile Phe  Glu Tyr Asp Gln Pro  Asp Cys Leu Leu Ser  Val Thr Met 
    1910                 1915                 1920             


Pro Ser  Met Val Arg His Ser  Leu Gln Thr Met Leu  Ser Val Gly 
    1925                 1930                 1935             


Tyr Tyr  Arg Asn Ile Tyr Thr  Pro Pro Asp Ser Ser  Thr Ser Phe 
    1940                 1945                 1950             


Ile Gln  Asp Tyr Ser Arg Asp  Gly Arg Leu Leu Gln  Thr Leu His 
    1955                 1960                 1965             


Leu Gly  Thr Gly Arg Arg Val  Leu Tyr Lys Tyr Thr  Lys Gln Ala 
    1970                 1975                 1980             


Arg Leu  Ser Glu Val Leu Tyr  Asp Thr Thr Gln Val  Thr Leu Thr 
    1985                 1990                 1995             


Tyr Glu  Glu Ser Ser Gly Val  Ile Lys Thr Ile His  Leu Met His 
    2000                 2005                 2010             


Asp Gly  Phe Ile Cys Thr Ile  Arg Tyr Arg Gln Thr  Gly Pro Leu 
    2015                 2020                 2025             


Ile Gly  Arg Gln Ile Phe Arg  Phe Ser Glu Glu Gly  Leu Val Asn 
    2030                 2035                 2040             


Ala Arg  Phe Asp Tyr Ser Tyr  Asn Asn Phe Arg Val  Thr Ser Met 
    2045                 2050                 2055             


Gln Ala  Val Ile Asn Glu Thr  Pro Leu Pro Ile Asp  Leu Tyr Arg 
    2060                 2065                 2070             


Tyr Val  Asp Val Ser Gly Arg  Thr Glu Gln Phe Gly  Lys Phe Ser 
    2075                 2080                 2085             


Val Ile  Asn Tyr Asp Leu Asn  Gln Val Ile Thr Thr  Thr Val Met 
    2090                 2095                 2100             


Lys His  Thr Lys Ile Phe Ser  Ala Asn Gly Gln Val  Ile Glu Val 
    2105                 2110                 2115             


Gln Tyr  Glu Ile Leu Lys Ala  Ile Ala Tyr Trp Met  Thr Ile Gln 
    2120                 2125                 2130             


Tyr Asp  Asn Val Gly Arg Met  Val Ile Cys Asp Ile  Arg Val Gly 
    2135                 2140                 2145             


Val Asp  Ala Asn Ile Thr Arg  Tyr Phe Tyr Glu Tyr  Asp Ala Asp 
    2150                 2155                 2160             


Gly Gln  Leu Gln Thr Val Ser  Val Asn Asp Lys Thr  Gln Trp Arg 
    2165                 2170                 2175             


Tyr Ser  Tyr Asp Leu Asn Gly  Asn Ile Asn Leu Leu  Ser His Gly 
    2180                 2185                 2190             


Lys Ser  Ala Arg Leu Thr Pro  Leu Arg Tyr Asp Leu  Arg Asp Arg 
    2195                 2200                 2205             


Ile Thr  Arg Leu Gly Glu Ile  Gln Tyr Lys Met Asp  Glu Asp Gly 
    2210                 2215                 2220             


Phe Leu  Arg Gln Arg Gly Asn  Asp Ile Phe Glu Tyr  Asn Ser Asn 
    2225                 2230                 2235             


Gly Leu  Leu Gln Lys Ala Tyr  Asn Lys Ala Ser Gly  Trp Thr Val 
    2240                 2245                 2250             


Gln Tyr  Tyr Tyr Asp Gly Leu  Gly Arg Arg Val Ala  Ser Lys Ser 
    2255                 2260                 2265             


Ser Leu  Gly Gln His Leu Gln  Phe Phe Tyr Ala Asp  Leu Thr Asn 
    2270                 2275                 2280             


Pro Ile  Arg Val Thr His Leu  Tyr Asn His Thr Ser  Ser Glu Ile 
    2285                 2290                 2295             


Thr Ser  Leu Tyr Tyr Asp Leu  Gln Gly His Leu Ile  Ala Met Glu 
    2300                 2305                 2310             


Leu Ser  Ser Gly Glu Glu Tyr  Tyr Val Ala Cys Asp  Asn Thr Gly 
    2315                 2320                 2325             


Thr Pro  Leu Ala Val Phe Ser  Ser Arg Gly Gln Val  Ile Lys Glu 
    2330                 2335                 2340             


Ile Leu  Tyr Thr Pro Tyr Gly  Asp Ile Tyr His Asp  Thr Tyr Pro 
    2345                 2350                 2355             


Asp Phe  Gln Val Ile Ile Gly  Phe His Gly Gly Leu  Tyr Asp Phe 
    2360                 2365                 2370             


Leu Thr  Lys Leu Val His Leu  Gly Gln Arg Asp Tyr  Asp Val Val 
    2375                 2380                 2385             


Ala Gly  Arg Trp Thr Thr Pro  Asn His His Ile Trp  Lys Gln Leu 
    2390                 2395                 2400             


Asn Leu  Leu Pro Lys Pro Phe  Asn Leu Tyr Ser Phe  Glu Asn Asn 
    2405                 2410                 2415             


Tyr Pro  Val Gly Lys Ile Gln  Asp Val Ala Lys Tyr  Thr Thr Asp 
    2420                 2425                 2430             


Ile Arg  Ser Trp Leu Glu Leu  Phe Gly Phe Gln Leu  His Asn Val 
    2435                 2440                 2445             


Leu Pro  Gly Phe Pro Lys Pro  Glu Leu Glu Asn Leu  Glu Leu Thr 
    2450                 2455                 2460             


Tyr Glu  Leu Leu Arg Leu Gln  Thr Lys Thr Gln Glu  Trp Asp Pro 
    2465                 2470                 2475             


Gly Lys  Thr Ile Leu Gly Ile  Gln Cys Glu Leu Gln  Lys Gln Leu 
    2480                 2485                 2490             


Arg Asn  Phe Ile Ser Leu Asp  Gln Leu Pro Met Thr  Pro Arg Tyr 
    2495                 2500                 2505             


Asn Asp  Gly Arg Cys Leu Glu  Gly Gly Lys Gln Pro  Arg Phe Ala 
    2510                 2515                 2520             


Ala Val  Pro Ser Val Phe Gly  Lys Gly Ile Lys Phe  Ala Ile Lys 
    2525                 2530                 2535             


Asp Gly  Ile Val Thr Ala Asp  Ile Ile Gly Val Ala  Asn Glu Asp 
    2540                 2545                 2550             


Ser Arg  Arg Leu Ala Ala Ile  Leu Asn Asn Ala His  Tyr Leu Glu 
    2555                 2560                 2565             


Asn Leu  His Phe Thr Ile Glu  Gly Arg Asp Thr His  Tyr Phe Ile 
    2570                 2575                 2580             


Lys Leu  Gly Ser Leu Glu Glu  Asp Leu Val Leu Ile  Gly Asn Thr 
    2585                 2590                 2595             


Gly Gly  Arg Arg Ile Leu Glu  Asn Gly Val Asn Val  Thr Val Ser 
    2600                 2605                 2610             


Gln Met  Thr Ser Val Leu Asn  Gly Arg Thr Arg Arg  Phe Ala Asp 
    2615                 2620                 2625             


Ile Gln  Leu Gln His Gly Ala  Leu Cys Phe Asn Ile  Arg Tyr Gly 
    2630                 2635                 2640             


Thr Thr  Val Glu Glu Glu Lys  Asn His Val Leu Glu  Ile Ala Arg 
    2645                 2650                 2655             


Gln Arg  Ala Val Ala Gln Ala  Trp Thr Lys Glu Gln  Arg Arg Leu 
    2660                 2665                 2670             


Gln Glu  Gly Glu Glu Gly Ile  Arg Ala Trp Thr Glu  Gly Glu Lys 
    2675                 2680                 2685             


Gln Gln  Leu Leu Ser Thr Gly  Arg Val Gln Gly Tyr  Asp Gly Tyr 
    2690                 2695                 2700             


Phe Val  Leu Ser Val Glu Gln  Tyr Leu Glu Leu Ser  Asp Ser Ala 
    2705                 2710                 2715             


Asn Asn  Ile His Phe Met Arg  Gln Ser Glu Ile Gly  Arg Arg 
    2720                 2725                 2730         


<210>  2050
<211>  2731
<212>  PRT
<213>  Homo sapiens

<400>  2050

Met Glu Gln Thr Asp Cys Lys Pro Tyr Gln Pro Leu Pro Lys Val Lys 
1               5                   10                  15      


His Glu Met Asp Leu Ala Tyr Thr Ser Ser Ser Asp Glu Ser Glu Asp 
            20                  25                  30          


Gly Arg Lys Pro Arg Gln Ser Tyr Asn Ser Arg Glu Thr Leu His Glu 
        35                  40                  45              


Tyr Asn Gln Glu Leu Arg Met Asn Tyr Asn Ser Gln Ser Arg Lys Arg 
    50                  55                  60                  


Lys Glu Val Glu Lys Ser Thr Gln Glu Met Glu Phe Cys Glu Thr Ser 
65                  70                  75                  80  


His Thr Leu Cys Ser Gly Tyr Gln Thr Asp Met His Ser Val Ser Arg 
                85                  90                  95      


His Gly Tyr Gln Leu Glu Met Gly Ser Asp Val Asp Thr Glu Thr Glu 
            100                 105                 110         


Gly Ala Ala Ser Pro Asp His Ala Leu Arg Met Trp Ile Arg Gly Met 
        115                 120                 125             


Lys Ser Glu His Ser Ser Cys Leu Ser Ser Arg Ala Asn Ser Ala Leu 
    130                 135                 140                 


Ser Leu Thr Asp Thr Asp His Glu Arg Lys Ser Asp Gly Glu Asn Gly 
145                 150                 155                 160 


Phe Lys Phe Ser Pro Val Cys Cys Asp Met Glu Ala Gln Ala Gly Ser 
                165                 170                 175     


Thr Gln Asp Val Gln Ser Ser Pro His Asn Gln Phe Thr Phe Arg Pro 
            180                 185                 190         


Leu Pro Pro Pro Pro Pro Pro Pro His Ala Cys Thr Cys Ala Arg Lys 
        195                 200                 205             


Pro Pro Pro Ala Ala Asp Ser Leu Gln Arg Arg Ser Met Thr Thr Arg 
    210                 215                 220                 


Ser Gln Pro Ser Pro Ala Ala Pro Ala Pro Pro Thr Ser Thr Gln Asp 
225                 230                 235                 240 


Ser Val His Leu His Asn Ser Trp Val Leu Asn Ser Asn Ile Pro Leu 
                245                 250                 255     


Glu Thr Arg His Phe Leu Phe Lys His Gly Ser Gly Ser Ser Ala Ile 
            260                 265                 270         


Phe Ser Ala Ala Ser Gln Asn Tyr Pro Leu Thr Ser Asn Thr Val Tyr 
        275                 280                 285             


Ser Pro Pro Pro Arg Pro Leu Pro Arg Ser Thr Phe Ser Arg Pro Ala 
    290                 295                 300                 


Phe Thr Phe Asn Lys Pro Tyr Arg Cys Cys Asn Trp Lys Cys Thr Ala 
305                 310                 315                 320 


Leu Ser Ala Thr Ala Ile Thr Val Thr Leu Ala Leu Leu Leu Ala Tyr 
                325                 330                 335     


Val Ile Val His Leu Phe Gly Leu Thr Trp Gln Leu Gln Pro Val Glu 
            340                 345                 350         


Gly Glu Leu Tyr Ala Asn Gly Val Ser Lys Gly Asn Arg Gly Thr Glu 
        355                 360                 365             


Ser Met Asp Thr Thr Tyr Ser Pro Ile Gly Gly Lys Val Ser Asp Lys 
    370                 375                 380                 


Ser Glu Lys Lys Val Phe Gln Lys Gly Arg Ala Ile Asp Thr Gly Glu 
385                 390                 395                 400 


Val Asp Ile Gly Ala Gln Val Met Gln Thr Ile Pro Pro Gly Leu Phe 
                405                 410                 415     


Trp Arg Phe Gln Ile Thr Ile His His Pro Ile Tyr Leu Lys Phe Asn 
            420                 425                 430         


Ile Ser Leu Ala Lys Asp Ser Leu Leu Gly Ile Tyr Gly Arg Arg Asn 
        435                 440                 445             


Ile Pro Pro Thr His Thr Gln Phe Asp Phe Val Lys Leu Met Asp Gly 
    450                 455                 460                 


Lys Gln Leu Val Lys Gln Asp Ser Lys Gly Ser Asp Asp Thr Gln His 
465                 470                 475                 480 


Ser Pro Arg Asn Leu Ile Leu Thr Ser Leu Gln Glu Thr Gly Phe Ile 
                485                 490                 495     


Glu Tyr Met Asp Gln Gly Pro Trp Tyr Leu Ala Phe Tyr Asn Asp Gly 
            500                 505                 510         


Lys Lys Met Glu Gln Val Phe Val Leu Thr Thr Ala Ile Glu Ile Met 
        515                 520                 525             


Asp Asp Cys Ser Thr Asn Cys Asn Gly Asn Gly Glu Cys Ile Ser Gly 
    530                 535                 540                 


His Cys His Cys Phe Pro Gly Phe Leu Gly Pro Asp Cys Ala Arg Asp 
545                 550                 555                 560 


Ser Cys Pro Val Leu Cys Gly Gly Asn Gly Glu Tyr Glu Lys Gly His 
                565                 570                 575     


Cys Val Cys Arg His Gly Trp Lys Gly Pro Glu Cys Asp Val Pro Glu 
            580                 585                 590         


Glu Gln Cys Ile Asp Pro Thr Cys Phe Gly His Gly Thr Cys Ile Met 
        595                 600                 605             


Gly Val Cys Ile Cys Val Pro Gly Tyr Lys Gly Glu Ile Cys Glu Glu 
    610                 615                 620                 


Glu Asp Cys Leu Asp Pro Met Cys Ser Asn His Gly Ile Cys Val Lys 
625                 630                 635                 640 


Gly Glu Cys His Cys Ser Thr Gly Trp Gly Gly Val Asn Cys Glu Thr 
                645                 650                 655     


Pro Leu Pro Val Cys Gln Glu Gln Cys Ser Gly His Gly Thr Phe Leu 
            660                 665                 670         


Leu Asp Ala Gly Val Cys Ser Cys Asp Pro Lys Trp Thr Gly Ser Asp 
        675                 680                 685             


Cys Ser Thr Glu Leu Cys Thr Met Glu Cys Gly Ser His Gly Val Cys 
    690                 695                 700                 


Ser Arg Gly Ile Cys Gln Cys Glu Glu Gly Trp Val Gly Pro Thr Cys 
705                 710                 715                 720 


Glu Glu Arg Ser Cys His Ser His Cys Thr Glu His Gly Gln Cys Lys 
                725                 730                 735     


Asp Gly Lys Cys Glu Cys Ser Pro Gly Trp Glu Gly Asp His Cys Thr 
            740                 745                 750         


Ile Ala His Tyr Leu Asp Ala Val Arg Asp Gly Cys Pro Gly Leu Cys 
        755                 760                 765             


Phe Gly Asn Gly Arg Cys Thr Leu Asp Gln Asn Gly Trp His Cys Val 
    770                 775                 780                 


Cys Gln Val Gly Trp Ser Gly Thr Gly Cys Asn Val Val Met Glu Met 
785                 790                 795                 800 


Leu Cys Gly Asp Asn Leu Asp Asn Asp Gly Asp Gly Leu Thr Asp Cys 
                805                 810                 815     


Val Asp Pro Asp Cys Cys Gln Gln Ser Asn Cys Tyr Ile Ser Pro Leu 
            820                 825                 830         


Cys Gln Gly Ser Pro Asp Pro Leu Asp Leu Ile Gln Gln Ser Gln Thr 
        835                 840                 845             


Leu Phe Ser Gln His Thr Ser Arg Leu Phe Tyr Asp Arg Ile Lys Phe 
    850                 855                 860                 


Leu Ile Gly Lys Asp Ser Thr His Val Ile Pro Pro Glu Val Ser Phe 
865                 870                 875                 880 


Asp Ser Arg Arg Ala Cys Val Ile Arg Gly Gln Val Val Ala Ile Asp 
                885                 890                 895     


Gly Thr Pro Leu Val Gly Val Asn Val Ser Phe Leu His His Ser Asp 
            900                 905                 910         


Tyr Gly Phe Thr Ile Ser Arg Gln Asp Gly Ser Phe Asp Leu Val Ala 
        915                 920                 925             


Ile Gly Gly Ile Ser Val Ile Leu Ile Phe Asp Arg Ser Pro Phe Leu 
    930                 935                 940                 


Pro Glu Lys Arg Thr Leu Trp Leu Pro Trp Asn Gln Phe Ile Val Val 
945                 950                 955                 960 


Glu Lys Val Thr Met Gln Arg Val Val Ser Asp Pro Pro Ser Cys Asp 
                965                 970                 975     


Ile Ser Asn Phe Ile Ser Pro Asn Pro Ile Val Leu Pro Ser Pro Leu 
            980                 985                 990         


Thr Ser Phe Gly Gly Ser Cys Pro  Glu Arg Gly Thr Ile  Val Pro Glu 
        995                 1000                 1005             


Leu Gln  Val Val Gln Glu Glu  Ile Pro Ile Pro Ser  Ser Phe Val 
    1010                 1015                 1020             


Arg Leu  Ser Tyr Leu Ser Ser  Arg Thr Pro Gly Tyr  Lys Thr Leu 
    1025                 1030                 1035             


Leu Arg  Ile Leu Leu Thr His  Ser Thr Ile Pro Val  Gly Met Ile 
    1040                 1045                 1050             


Lys Val  His Leu Thr Val Ala  Val Glu Gly Arg Leu  Thr Gln Lys 
    1055                 1060                 1065             


Trp Phe  Pro Ala Ala Ile Asn  Leu Val Tyr Thr Phe  Ala Trp Asn 
    1070                 1075                 1080             


Lys Thr  Asp Ile Tyr Gly Gln  Lys Val Trp Gly Leu  Ala Glu Ala 
    1085                 1090                 1095             


Leu Val  Ser Val Gly Tyr Glu  Tyr Glu Thr Cys Pro  Asp Phe Ile 
    1100                 1105                 1110             


Leu Trp  Glu Gln Arg Thr Val  Val Leu Gln Gly Phe  Glu Met Asp 
    1115                 1120                 1125             


Ala Ser  Asn Leu Gly Gly Trp  Ser Leu Asn Lys His  His Ile Leu 
    1130                 1135                 1140             


Asn Pro  Gln Ser Gly Ile Ile  His Lys Gly Asn Gly  Glu Asn Met 
    1145                 1150                 1155             


Phe Ile  Ser Gln Gln Pro Pro  Val Ile Ser Thr Ile  Met Gly Asn 
    1160                 1165                 1170             


Gly His  Gln Arg Ser Val Ala  Cys Thr Asn Cys Asn  Gly Pro Ala 
    1175                 1180                 1185             


His Asn  Asn Lys Leu Phe Ala  Pro Val Ala Leu Ala  Ser Gly Pro 
    1190                 1195                 1200             


Asp Gly  Ser Val Tyr Val Gly  Asp Phe Asn Phe Val  Arg Arg Ile 
    1205                 1210                 1215             


Phe Pro  Ser Gly Asn Ser Val  Ser Ile Leu Glu Leu  Arg Asn Arg 
    1220                 1225                 1230             


Asp Thr  Arg His Ser Thr Ser  Pro Ala His Lys Tyr  Tyr Leu Ala 
    1235                 1240                 1245             


Met Asp  Pro Val Ser Glu Ser  Leu Tyr Leu Ser Asp  Thr Asn Thr 
    1250                 1255                 1260             


Arg Lys  Val Tyr Lys Leu Lys  Ser Leu Val Glu Thr  Lys Asp Leu 
    1265                 1270                 1275             


Ser Lys  Asn Phe Glu Val Val  Ala Gly Thr Gly Asp  Gln Cys Leu 
    1280                 1285                 1290             


Pro Phe  Asp Gln Ser His Cys  Gly Asp Gly Gly Arg  Ala Ser Glu 
    1295                 1300                 1305             


Ala Ser  Leu Asn Ser Pro Arg  Gly Ile Thr Val Asp  Arg His Gly 
    1310                 1315                 1320             


Phe Ile  Tyr Phe Val Asp Gly  Thr Met Ile Arg Lys  Ile Asp Glu 
    1325                 1330                 1335             


Asn Ala  Val Ile Thr Thr Val  Ile Gly Ser Asn Gly  Leu Thr Ser 
    1340                 1345                 1350             


Thr Gln  Pro Leu Ser Cys Asp  Ser Gly Met Asp Ile  Thr Gln Val 
    1355                 1360                 1365             


Arg Leu  Glu Trp Pro Thr Asp  Leu Ala Val Asn Pro  Met Asp Asn 
    1370                 1375                 1380             


Ser Leu  Tyr Val Leu Asp Asn  Asn Ile Val Leu Gln  Ile Ser Glu 
    1385                 1390                 1395             


Asn Arg  Arg Val Arg Ile Ile  Ala Gly Arg Pro Ile  His Cys Gln 
    1400                 1405                 1410             


Val Pro  Gly Ile Asp His Phe  Leu Val Ser Lys Val  Ala Ile His 
    1415                 1420                 1425             


Ser Thr  Leu Glu Ser Ala Arg  Ala Ile Ser Val Ser  His Ser Gly 
    1430                 1435                 1440             


Leu Leu  Phe Ile Ala Glu Thr  Asp Glu Arg Lys Val  Asn Arg Ile 
    1445                 1450                 1455             


Gln Gln  Val Thr Thr Asn Gly  Glu Ile Tyr Ile Ile  Ala Gly Ala 
    1460                 1465                 1470             


Pro Thr  Asp Cys Asp Cys Lys  Ile Asp Pro Asn Cys  Asp Cys Phe 
    1475                 1480                 1485             


Ser Gly  Asp Gly Gly Tyr Ala  Lys Asp Ala Lys Met  Lys Ala Pro 
    1490                 1495                 1500             


Ser Ser  Leu Ala Val Ser Pro  Asp Gly Thr Leu Tyr  Val Ala Asp 
    1505                 1510                 1515             


Leu Gly  Asn Val Arg Ile Arg  Thr Ile Ser Arg Asn  Gln Ala His 
    1520                 1525                 1530             


Leu Asn  Asp Met Asn Ile Tyr  Glu Ile Ala Ser Pro  Ala Asp Gln 
    1535                 1540                 1545             


Glu Leu  Tyr Gln Phe Thr Val  Asn Gly Thr His Leu  His Thr Leu 
    1550                 1555                 1560             


Asn Leu  Ile Thr Arg Asp Tyr  Val Tyr Asn Phe Thr  Tyr Asn Ser 
    1565                 1570                 1575             


Glu Gly  Asp Leu Gly Ala Ile  Thr Ser Ser Asn Gly  Asn Ser Val 
    1580                 1585                 1590             


His Ile  Arg Arg Asp Ala Gly  Gly Met Pro Leu Trp  Leu Val Val 
    1595                 1600                 1605             


Pro Gly  Gly Gln Val Tyr Trp  Leu Thr Ile Ser Ser  Asn Gly Val 
    1610                 1615                 1620             


Leu Lys  Arg Val Ser Ala Gln  Gly Tyr Asn Leu Ala  Leu Met Thr 
    1625                 1630                 1635             


Tyr Pro  Gly Asn Thr Gly Leu  Leu Ala Thr Lys Ser  Asn Glu Asn 
    1640                 1645                 1650             


Gly Trp  Thr Thr Val Tyr Glu  Tyr Asp Pro Glu Gly  His Leu Thr 
    1655                 1660                 1665             


Asn Ala  Thr Phe Pro Thr Gly  Glu Val Ser Ser Phe  His Ser Asp 
    1670                 1675                 1680             


Leu Glu  Lys Leu Thr Lys Val  Glu Leu Asp Thr Ser  Asn Arg Glu 
    1685                 1690                 1695             


Asn Val  Leu Met Ser Thr Asn  Leu Thr Ala Thr Ser  Thr Ile Tyr 
    1700                 1705                 1710             


Ile Leu  Lys Gln Glu Asn Thr  Gln Ser Thr Tyr Arg  Val Asn Pro 
    1715                 1720                 1725             


Asp Gly  Ser Leu Arg Val Thr  Phe Ala Ser Gly Met  Glu Ile Gly 
    1730                 1735                 1740             


Leu Ser  Ser Glu Pro His Ile  Leu Ala Gly Ala Val  Asn Pro Thr 
    1745                 1750                 1755             


Leu Gly  Lys Cys Asn Ile Ser  Leu Pro Gly Glu His  Asn Ala Asn 
    1760                 1765                 1770             


Leu Ile  Glu Trp Arg Gln Arg  Lys Glu Gln Asn Lys  Gly Asn Val 
    1775                 1780                 1785             


Ser Ala  Phe Glu Arg Arg Leu  Arg Ala His Asn Arg  Asn Leu Leu 
    1790                 1795                 1800             


Ser Ile  Asp Phe Asp His Ile  Thr Arg Thr Gly Lys  Ile Tyr Asp 
    1805                 1810                 1815             


Asp His  Arg Lys Phe Thr Leu  Arg Ile Leu Tyr Asp  Gln Thr Gly 
    1820                 1825                 1830             


Arg Pro  Ile Leu Trp Ser Pro  Val Ser Arg Tyr Asn  Glu Val Asn 
    1835                 1840                 1845             


Ile Thr  Tyr Ser Pro Ser Gly  Leu Val Thr Phe Ile  Gln Arg Gly 
    1850                 1855                 1860             


Thr Trp  Asn Glu Lys Met Glu  Tyr Asp Gln Ser Gly  Lys Ile Ile 
    1865                 1870                 1875             


Ser Arg  Thr Trp Ala Asp Gly  Lys Ile Trp Ser Tyr  Thr Tyr Leu 
    1880                 1885                 1890             


Glu Lys  Ser Val Met Leu Leu  Leu His Ser Gln Arg  Arg Tyr Ile 
    1895                 1900                 1905             


Phe Glu  Tyr Asp Gln Pro Asp  Cys Leu Leu Ser Val  Thr Met Pro 
    1910                 1915                 1920             


Ser Met  Val Arg His Ser Leu  Gln Thr Met Leu Ser  Val Gly Tyr 
    1925                 1930                 1935             


Tyr Arg  Asn Ile Tyr Thr Pro  Pro Asp Ser Ser Thr  Ser Phe Ile 
    1940                 1945                 1950             


Gln Asp  Tyr Ser Arg Asp Gly  Arg Leu Leu Gln Thr  Leu His Leu 
    1955                 1960                 1965             


Gly Thr  Gly Arg Arg Val Leu  Tyr Lys Tyr Thr Lys  Gln Ala Arg 
    1970                 1975                 1980             


Leu Ser  Glu Val Leu Tyr Asp  Thr Thr Gln Val Thr  Leu Thr Tyr 
    1985                 1990                 1995             


Glu Glu  Ser Ser Gly Val Ile  Lys Thr Ile His Leu  Met His Asp 
    2000                 2005                 2010             


Gly Phe  Ile Cys Thr Ile Arg  Tyr Arg Gln Thr Gly  Pro Leu Ile 
    2015                 2020                 2025             


Gly Arg  Gln Ile Phe Arg Phe  Ser Glu Glu Gly Leu  Val Asn Ala 
    2030                 2035                 2040             


Arg Phe  Asp Tyr Ser Tyr Asn  Asn Phe Arg Val Thr  Ser Met Gln 
    2045                 2050                 2055             


Ala Val  Ile Asn Glu Thr Pro  Leu Pro Ile Asp Leu  Tyr Arg Tyr 
    2060                 2065                 2070             


Val Asp  Val Ser Gly Arg Thr  Glu Gln Phe Gly Lys  Phe Ser Val 
    2075                 2080                 2085             


Ile Asn  Tyr Asp Leu Asn Gln  Val Ile Thr Thr Thr  Val Met Lys 
    2090                 2095                 2100             


His Thr  Lys Ile Phe Ser Ala  Asn Gly Gln Val Ile  Glu Val Gln 
    2105                 2110                 2115             


Tyr Glu  Ile Leu Lys Ala Ile  Ala Tyr Trp Met Thr  Ile Gln Tyr 
    2120                 2125                 2130             


Asp Asn  Val Gly Arg Met Val  Ile Cys Asp Ile Arg  Val Gly Val 
    2135                 2140                 2145             


Asp Ala  Asn Ile Thr Arg Tyr  Phe Tyr Glu Tyr Asp  Ala Asp Gly 
    2150                 2155                 2160             


Gln Leu  Gln Thr Val Ser Val  Asn Asp Lys Thr Gln  Trp Arg Tyr 
    2165                 2170                 2175             


Ser Tyr  Asp Leu Asn Gly Asn  Ile Asn Leu Leu Ser  His Gly Lys 
    2180                 2185                 2190             


Ser Ala  Arg Leu Thr Pro Leu  Arg Tyr Asp Leu Arg  Asp Arg Ile 
    2195                 2200                 2205             


Thr Arg  Leu Gly Glu Ile Gln  Tyr Lys Met Asp Glu  Asp Gly Phe 
    2210                 2215                 2220             


Leu Arg  Gln Arg Gly Asn Asp  Ile Phe Glu Tyr Asn  Ser Asn Gly 
    2225                 2230                 2235             


Leu Leu  Gln Lys Ala Tyr Asn  Lys Ala Ser Gly Trp  Thr Val Gln 
    2240                 2245                 2250             


Tyr Tyr  Tyr Asp Gly Leu Gly  Arg Arg Val Ala Ser  Lys Ser Ser 
    2255                 2260                 2265             


Leu Gly  Gln His Leu Gln Phe  Phe Tyr Ala Asp Leu  Thr Asn Pro 
    2270                 2275                 2280             


Ile Arg  Val Thr His Leu Tyr  Asn His Thr Ser Ser  Glu Ile Thr 
    2285                 2290                 2295             


Ser Leu  Tyr Tyr Asp Leu Gln  Gly His Leu Ile Ala  Met Glu Leu 
    2300                 2305                 2310             


Ser Ser  Gly Glu Glu Tyr Tyr  Val Ala Cys Asp Asn  Thr Gly Thr 
    2315                 2320                 2325             


Pro Leu  Ala Val Phe Ser Ser  Arg Gly Gln Val Ile  Lys Glu Ile 
    2330                 2335                 2340             


Leu Tyr  Thr Pro Tyr Gly Asp  Ile Tyr His Asp Thr  Tyr Pro Asp 
    2345                 2350                 2355             


Phe Gln  Val Ile Ile Gly Phe  His Gly Gly Leu Tyr  Asp Phe Leu 
    2360                 2365                 2370             


Thr Lys  Leu Val His Leu Gly  Gln Arg Asp Tyr Asp  Val Val Ala 
    2375                 2380                 2385             


Gly Arg  Trp Thr Thr Pro Asn  His His Ile Trp Lys  Gln Leu Asn 
    2390                 2395                 2400             


Leu Leu  Pro Lys Pro Phe Asn  Leu Tyr Ser Phe Glu  Asn Asn Tyr 
    2405                 2410                 2415             


Pro Val  Gly Lys Ile Gln Asp  Val Ala Lys Tyr Thr  Thr Asp Ile 
    2420                 2425                 2430             


Arg Ser  Trp Leu Glu Leu Phe  Gly Phe Gln Leu His  Asn Val Leu 
    2435                 2440                 2445             


Pro Gly  Phe Pro Lys Pro Glu  Leu Glu Asn Leu Glu  Leu Thr Tyr 
    2450                 2455                 2460             


Glu Leu  Leu Arg Leu Gln Thr  Lys Thr Gln Glu Trp  Asp Pro Gly 
    2465                 2470                 2475             


Lys Thr  Ile Leu Gly Ile Gln  Cys Glu Leu Gln Lys  Gln Leu Arg 
    2480                 2485                 2490             


Asn Phe  Ile Ser Leu Asp Gln  Leu Pro Met Thr Pro  Arg Tyr Asn 
    2495                 2500                 2505             


Asp Gly  Arg Cys Leu Glu Gly  Gly Lys Gln Pro Arg  Phe Ala Ala 
    2510                 2515                 2520             


Val Pro  Ser Val Phe Gly Lys  Gly Ile Lys Phe Ala  Ile Lys Asp 
    2525                 2530                 2535             


Gly Ile  Val Thr Ala Asp Ile  Ile Gly Val Ala Asn  Glu Asp Ser 
    2540                 2545                 2550             


Arg Arg  Leu Ala Ala Ile Leu  Asn Asn Ala His Tyr  Leu Glu Asn 
    2555                 2560                 2565             


Leu His  Phe Thr Ile Glu Gly  Arg Asp Thr His Tyr  Phe Ile Lys 
    2570                 2575                 2580             


Leu Gly  Ser Leu Glu Glu Asp  Leu Val Leu Ile Gly  Asn Thr Gly 
    2585                 2590                 2595             


Gly Arg  Arg Ile Leu Glu Asn  Gly Val Asn Val Thr  Val Ser Gln 
    2600                 2605                 2610             


Met Thr  Ser Val Leu Asn Gly  Arg Thr Arg Arg Phe  Ala Asp Ile 
    2615                 2620                 2625             


Gln Leu  Gln His Gly Ala Leu  Cys Phe Asn Ile Arg  Tyr Gly Thr 
    2630                 2635                 2640             


Thr Val  Glu Glu Glu Lys Asn  His Val Leu Glu Ile  Ala Arg Gln 
    2645                 2650                 2655             


Arg Ala  Val Ala Gln Ala Trp  Thr Lys Glu Gln Arg  Arg Leu Gln 
    2660                 2665                 2670             


Glu Gly  Glu Glu Gly Ile Arg  Ala Trp Thr Glu Gly  Glu Lys Gln 
    2675                 2680                 2685             


Gln Leu  Leu Ser Thr Gly Arg  Val Gln Gly Tyr Asp  Gly Tyr Phe 
    2690                 2695                 2700             


Val Leu  Ser Val Glu Gln Tyr  Leu Glu Leu Ser Asp  Ser Ala Asn 
    2705                 2710                 2715             


Asn Ile  His Phe Met Arg Gln  Ser Glu Ile Gly Arg  Arg 
    2720                 2725                 2730     


<210>  2051
<211>  701
<212>  PRT
<213>  Homo sapiens

<400>  2051

Met Gly His Leu Leu Ser Lys Glu Pro Arg Asn Arg Pro Ser Gln Lys 
1               5                   10                  15      


Arg Pro Arg Cys Cys Ser Trp Cys Arg Arg Arg Arg Pro Leu Leu Arg 
            20                  25                  30          


Leu Pro Arg Arg Thr Pro Ala Lys Val Pro Pro Gln Pro Ala Ala Pro 
        35                  40                  45              


Arg Ser Arg Asp Cys Phe Phe Arg Gly Pro Cys Met Leu Cys Phe Ile 
    50                  55                  60                  


Val His Ser Pro Gly Ala Pro Ala Pro Ala Gly Pro Glu Glu Glu Pro 
65                  70                  75                  80  


Pro Leu Ser Pro Pro Pro Arg Asp Gly Ala Tyr Ala Ala Ala Ser Ser 
                85                  90                  95      


Ser Gln His Leu Ala Arg Arg Tyr Ala Ala Leu Ala Ala Glu Asp Cys 
            100                 105                 110         


Ala Ala Ala Ala Arg Arg Phe Leu Leu Ser Ser Ala Ala Ala Ala Ala 
        115                 120                 125             


Ala Ala Ala Ala Ser Ala Ser Ser Pro Ala Ser Cys Cys Lys Glu Leu 
    130                 135                 140                 


Gly Leu Ala Ala Ala Ala Ala Trp Glu Gln Gln Gly Arg Ser Leu Phe 
145                 150                 155                 160 


Leu Ala Ser Leu Gly Pro Val Arg Phe Leu Gly Pro Pro Ala Ala Val 
                165                 170                 175     


Gln Leu Phe Arg Gly Pro Thr Pro Ser Pro Ala Glu Leu Pro Thr Pro 
            180                 185                 190         


Pro Glu Met Val Cys Lys Arg Lys Gly Ala Gly Val Pro Ala Cys Thr 
        195                 200                 205             


Pro Cys Lys Gln Pro Arg Cys Gly Gly Gly Gly Cys Gly Gly Gly Gly 
    210                 215                 220                 


Gly Gly Gly Gly Gly Gly Gly Pro Ala Gly Gly Gly Ala Ser Pro Pro 
225                 230                 235                 240 


Arg Pro Pro Asp Ala Gly Cys Cys Gln Ala Pro Glu Gln Pro Pro Gln 
                245                 250                 255     


Pro Leu Cys Pro Pro Pro Ser Ser Pro Thr Ser Glu Gly Ala Pro Thr 
            260                 265                 270         


Glu Ala Gly Gly Asp Ala Val Arg Ala Gly Gly Thr Ala Pro Leu Ser 
        275                 280                 285             


Ala Gln Gln Gln His Glu Cys Gly Asp Ala Asp Cys Arg Glu Ser Pro 
    290                 295                 300                 


Glu Asn Pro Cys Asp Cys His Arg Glu Pro Pro Pro Glu Thr Pro Asp 
305                 310                 315                 320 


Ile Asn Gln Leu Pro Pro Ser Ile Leu Leu Lys Ile Phe Ser Asn Leu 
                325                 330                 335     


Ser Leu Asp Glu Arg Cys Leu Ser Ala Ser Leu Val Cys Lys Tyr Trp 
            340                 345                 350         


Arg Asp Leu Cys Leu Asp Phe Gln Phe Trp Lys Gln Leu Asp Leu Ser 
        355                 360                 365             


Ser Arg Gln Gln Val Thr Asp Glu Leu Leu Glu Lys Ile Ala Ser Arg 
    370                 375                 380                 


Ser Gln Asn Ile Ile Glu Ile Asn Ile Ser Asp Cys Arg Ser Met Ser 
385                 390                 395                 400 


Asp Asn Gly Val Cys Val Leu Ala Phe Lys Cys Pro Gly Leu Leu Arg 
                405                 410                 415     


Tyr Thr Ala Tyr Arg Cys Lys Gln Leu Ser Asp Thr Ser Ile Ile Ala 
            420                 425                 430         


Val Ala Ser His Cys Pro Leu Leu Gln Lys Val His Val Gly Asn Gln 
        435                 440                 445             


Asp Lys Leu Thr Asp Glu Gly Leu Lys Gln Leu Gly Ser Lys Cys Arg 
    450                 455                 460                 


Glu Leu Lys Asp Ile His Phe Gly Gln Cys Tyr Lys Ile Ser Asp Glu 
465                 470                 475                 480 


Gly Met Ile Val Ile Ala Lys Gly Cys Leu Lys Leu Gln Arg Ile Tyr 
                485                 490                 495     


Met Gln Glu Asn Lys Leu Val Thr Asp Gln Ser Val Lys Ala Phe Ala 
            500                 505                 510         


Glu His Cys Pro Glu Leu Gln Tyr Val Gly Phe Met Gly Cys Ser Val 
        515                 520                 525             


Thr Ser Lys Gly Val Ile His Leu Thr Lys Leu Arg Asn Leu Ser Ser 
    530                 535                 540                 


Leu Asp Leu Arg His Ile Thr Glu Leu Asp Asn Glu Thr Val Met Glu 
545                 550                 555                 560 


Ile Val Lys Arg Cys Lys Asn Leu Ser Ser Leu Asn Leu Cys Leu Asn 
                565                 570                 575     


Trp Ile Ile Asn Asp Arg Cys Val Glu Val Ile Ala Lys Glu Gly Gln 
            580                 585                 590         


Asn Leu Lys Glu Leu Tyr Leu Val Ser Cys Lys Ile Thr Asp Tyr Ala 
        595                 600                 605             


Leu Ile Ala Ile Gly Arg Tyr Ser Met Thr Ile Glu Thr Val Asp Val 
    610                 615                 620                 


Gly Trp Cys Lys Glu Ile Thr Asp Gln Gly Ala Thr Leu Ile Ala Gln 
625                 630                 635                 640 


Ser Ser Lys Ser Leu Arg Tyr Leu Gly Leu Met Arg Cys Asp Lys Val 
                645                 650                 655     


Asn Glu Val Thr Val Glu Gln Leu Val Gln Gln Tyr Pro His Ile Thr 
            660                 665                 670         


Phe Ser Thr Val Leu Gln Asp Cys Lys Arg Thr Leu Glu Arg Ala Tyr 
        675                 680                 685             


Gln Met Gly Trp Thr Pro Asn Met Ser Ala Ala Ser Ser 
    690                 695                 700     


<210>  2052
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  2052

Met Arg Ser Gly Gly Arg Gly Arg Pro Arg Leu Arg Leu Gly Glu Arg 
1               5                   10                  15      


Gly Leu Met Glu Pro Leu Leu Pro Pro Lys Arg Arg Leu Leu Pro Arg 
            20                  25                  30          


Val Arg Leu Leu Pro Leu Leu Leu Ala Leu Ala Val Gly Ser Ala Phe 
        35                  40                  45              


Tyr Thr Ile Trp Ser Gly Trp His Arg Arg Thr Glu Glu Leu Pro Leu 
    50                  55                  60                  


Gly Arg Glu Leu Arg Val Pro Leu Ile Gly Ser Leu Pro Glu Ala Arg 
65                  70                  75                  80  


Leu Arg Arg Val Val Gly Gln Leu Asp Pro Gln Arg Leu Trp Ser Thr 
                85                  90                  95      


Tyr Leu Arg Pro Leu Leu Val Val Arg Thr Pro Gly Ser Pro Gly Asn 
            100                 105                 110         


Leu Gln Val Arg Lys Ala Ala Pro Val Thr Leu Gln Leu Leu Phe Leu 
        115                 120                 125             


Asp Gly Glu Glu Ala Leu Lys Glu Trp Gly Pro Lys Asp Ser Leu Tyr 
    130                 135                 140                 


Gly Ser Arg His Leu Ala Gln Leu Met Glu Ser Ile Pro His Ser Pro 
145                 150                 155                 160 


Gly Pro Thr Arg Ile Gln Ala Ile Glu Leu Phe Met Leu Leu Asp Leu 
                165                 170                 175     


Leu Gly Ala Pro Asn Pro Thr Phe Tyr Ser His Phe Pro Arg Thr Val 
            180                 185                 190         


Arg Trp Phe His Arg Leu Arg Ser Ile Glu Lys Arg Leu His Arg Leu 
        195                 200                 205             


Asn Leu Leu Gln Ser His Pro Gln Glu Val Met Tyr Phe Gln Pro Gly 
    210                 215                 220                 


Glu Pro Phe Gly Ser Val Glu Asp Asp His Ile Pro Phe Leu Arg Arg 
225                 230                 235                 240 


Gly Val Pro Val Leu His Leu Ile Ser Thr Pro Phe Pro Ala Val Trp 
                245                 250                 255     


His Thr Pro Ala Asp Thr Glu Val Asn Leu His Pro Pro Thr Val His 
            260                 265                 270         


Asn Leu Cys Arg Ile Leu Ala Val Phe Leu Ala Glu Tyr Leu Gly Leu 
        275                 280                 285             


<210>  2053
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  2053

Met Glu Ala Leu Gly Ser Gly His Tyr Val Gly Gly Ser Ile Arg Ser 
1               5                   10                  15      


Met Ala Ala Ala Ala Leu Ser Gly Leu Ala Val Arg Leu Ser Arg Pro 
            20                  25                  30          


Gln Gly Thr Arg Gly Ser Tyr Gly Ala Phe Cys Lys Thr Leu Thr Arg 
        35                  40                  45              


Thr Leu Leu Thr Phe Phe Asp Leu Ala Trp Arg Leu Arg Lys Asn Phe 
    50                  55                  60                  


Phe Tyr Phe Tyr Ile Leu Ala Ser Val Ile Leu Asn Val His Leu Gln 
65                  70                  75                  80  


Val Tyr Ile 
            


<210>  2054
<211>  547
<212>  PRT
<213>  Homo sapiens

<400>  2054

Met Ala Val Ile Ser Leu Leu Phe Leu Ala Val Met Tyr Val Val His 
1               5                   10                  15      


His Pro Leu Met Val Ser Asp Arg Met Asp Leu Asp Thr Leu Ala Arg 
            20                  25                  30          


Ser Arg Gln Leu Glu Lys Arg Met Ser Glu Glu Met Arg Leu Leu Glu 
        35                  40                  45              


Met Glu Phe Glu Glu Arg Lys Arg Ala Ala Glu Gln Arg Gln Lys Ala 
    50                  55                  60                  


Glu Asn Phe Trp Thr Gly Asp Thr Ser Ser Asp Gln Leu Val Leu Gly 
65                  70                  75                  80  


Lys Lys Asp Met Gly Trp Pro Phe Gln Ala Asp Gly Gln Glu Gly Pro 
                85                  90                  95      


Leu Gly Trp Met Leu Gly Asn Leu Trp Asn Thr Gly Leu Phe Cys Leu 
            100                 105                 110         


Phe Leu Val Phe Glu Leu Leu Arg Gln Asn Met Gln His Glu Pro Ala 
        115                 120                 125             


Phe Asp Ser Ser Ser Glu Glu Glu Glu Glu Glu Val Arg Val Val Pro 
    130                 135                 140                 


Val Thr Ser Tyr Asn Trp Leu Thr Asp Phe Pro Ser Gln Glu Ala Leu 
145                 150                 155                 160 


Asp Ser Phe Tyr Lys His Tyr Val Gln Asn Ala Ile Arg Asp Leu Pro 
                165                 170                 175     


Cys Thr Cys Glu Phe Val Glu Ser Phe Val Asp Asp Leu Ile Glu Ala 
            180                 185                 190         


Cys Arg Val Leu Ser Arg Gln Glu Ala His Pro Gln Leu Glu Asp Cys 
        195                 200                 205             


Leu Gly Ile Gly Ala Ala Phe Glu Lys Trp Gly Thr Leu His Glu Thr 
    210                 215                 220                 


Gln Lys Phe Asp Ile Leu Val Pro Ile Val Pro Pro Gln Gly Thr Met 
225                 230                 235                 240 


Phe Val Leu Glu Met Arg Asp Pro Ala Leu Gly Arg Arg Cys Gly Cys 
                245                 250                 255     


Val Leu Val Glu Ser Glu Cys Val Cys Lys Arg Glu Lys Leu Leu Gly 
            260                 265                 270         


Asp Val Leu Cys Leu Val His His His Arg Asp Pro Ser Ala Val Leu 
        275                 280                 285             


Gly Lys Cys Ser Ser Ser Ile Lys Ala Ala Leu Cys Thr Gly Phe His 
    290                 295                 300                 


Leu Asp Val Cys Lys Thr Val Gln Trp Phe Arg Asn Met Met Gly Asn 
305                 310                 315                 320 


Ala Trp Ala Leu Val Ala His Lys Tyr Asp Phe Lys Leu Ser Leu Pro 
                325                 330                 335     


Pro Ser Thr Thr Ser Cys Lys Leu Arg Leu Asp Tyr Arg Ser Gly Arg 
            340                 345                 350         


Phe Leu Ser Ile His Leu Val Leu Gly Val Gln Arg Glu Asp Thr Leu 
        355                 360                 365             


Val Tyr Leu Val Ser Gln Ala Pro Asp Gln Glu Gln Leu Thr Ser Val 
    370                 375                 380                 


Asp Trp Pro Glu Ser Phe Val Ala Cys Glu His Leu Phe Leu Lys Leu 
385                 390                 395                 400 


Val Gly Arg Phe Ala Pro Glu Asn Thr Cys His Leu Lys Cys Leu Gln 
                405                 410                 415     


Ile Ile Leu Ser Leu Arg Gln His Gln Ser Leu Pro His Gly Ala Ser 
            420                 425                 430         


Arg Pro Ile Leu Thr Ser Tyr His Phe Lys Thr Ala Leu Met His Leu 
        435                 440                 445             


Leu Leu Arg Leu Pro Leu Thr Asp Trp Ala His Asn Met Leu Ser Gln 
    450                 455                 460                 


Arg Leu Gln Asp Ile Leu Trp Phe Leu Gly Arg Gly Leu Gln Gln Arg 
465                 470                 475                 480 


Ser Leu His His Phe Leu Ile Gly Asn Asn Phe Leu Pro Leu Thr Ile 
                485                 490                 495     


Pro Ile Pro Lys Thr Phe Arg Asn Ala Glu Pro Val Asn Leu Phe Gln 
            500                 505                 510         


His Leu Val Leu Asn Pro Lys Ala His Ser Gln Ala Val Glu Glu Phe 
        515                 520                 525             


Gln Asn Leu Leu Thr Gln Val Lys Thr Leu Pro His Ala Pro Leu Ala 
    530                 535                 540                 


Ala Ala Pro 
545         


<210>  2055
<211>  547
<212>  PRT
<213>  Homo sapiens

<400>  2055

Met Ala Val Ile Ser Leu Leu Phe Leu Ala Val Met Tyr Val Val His 
1               5                   10                  15      


His Pro Leu Met Val Ser Asp Arg Met Asp Leu Asp Thr Leu Ala Arg 
            20                  25                  30          


Ser Arg Gln Leu Glu Lys Arg Met Ser Glu Glu Met Arg Leu Leu Glu 
        35                  40                  45              


Met Glu Phe Glu Glu Arg Lys Arg Ala Ala Glu Gln Arg Gln Lys Ala 
    50                  55                  60                  


Glu Asn Phe Trp Thr Gly Asp Thr Ser Ser Asp Gln Leu Val Leu Gly 
65                  70                  75                  80  


Lys Lys Asp Met Gly Trp Pro Phe Gln Ala Asp Gly Gln Glu Gly Pro 
                85                  90                  95      


Leu Gly Trp Met Leu Gly Asn Leu Trp Asn Thr Gly Leu Phe Cys Leu 
            100                 105                 110         


Phe Leu Val Phe Glu Leu Leu Arg Gln Asn Met Gln His Glu Pro Ala 
        115                 120                 125             


Phe Asp Ser Ser Ser Glu Glu Glu Glu Glu Glu Val Arg Val Val Pro 
    130                 135                 140                 


Val Thr Ser Tyr Asn Trp Leu Thr Asp Phe Pro Ser Gln Glu Ala Leu 
145                 150                 155                 160 


Asp Ser Phe Tyr Lys His Tyr Val Gln Asn Ala Ile Arg Asp Leu Pro 
                165                 170                 175     


Cys Thr Cys Glu Phe Val Glu Ser Phe Val Asp Asp Leu Ile Glu Ala 
            180                 185                 190         


Cys Arg Val Leu Ser Arg Gln Glu Ala His Pro Gln Leu Glu Asp Cys 
        195                 200                 205             


Leu Gly Ile Gly Ala Ala Phe Glu Lys Trp Gly Thr Leu His Glu Thr 
    210                 215                 220                 


Gln Lys Phe Asp Ile Leu Val Pro Ile Val Pro Pro Gln Gly Thr Met 
225                 230                 235                 240 


Phe Val Leu Glu Met Arg Asp Pro Ala Leu Gly Arg Arg Cys Gly Cys 
                245                 250                 255     


Val Leu Val Glu Ser Glu Cys Val Cys Lys Arg Glu Lys Leu Leu Gly 
            260                 265                 270         


Asp Val Leu Cys Leu Val His His His Arg Asp Pro Ser Ala Val Leu 
        275                 280                 285             


Gly Lys Cys Ser Ser Ser Ile Lys Ala Ala Leu Cys Thr Gly Phe His 
    290                 295                 300                 


Leu Asp Val Cys Lys Thr Val Gln Trp Phe Arg Asn Met Met Gly Asn 
305                 310                 315                 320 


Ala Trp Ala Leu Val Ala His Lys Tyr Asp Phe Lys Leu Ser Leu Pro 
                325                 330                 335     


Pro Ser Thr Thr Ser Cys Lys Leu Arg Leu Asp Tyr Arg Ser Gly Arg 
            340                 345                 350         


Phe Leu Ser Ile His Leu Val Leu Gly Val Gln Arg Glu Asp Thr Leu 
        355                 360                 365             


Val Tyr Leu Val Ser Gln Ala Pro Asp Gln Glu Gln Leu Thr Ser Val 
    370                 375                 380                 


Asp Trp Pro Glu Ser Phe Val Ala Cys Glu His Leu Phe Leu Lys Leu 
385                 390                 395                 400 


Val Gly Arg Phe Ala Pro Glu Asn Thr Cys His Leu Lys Cys Leu Gln 
                405                 410                 415     


Ile Ile Leu Ser Leu Arg Gln His Gln Ser Leu Pro His Gly Ala Ser 
            420                 425                 430         


Arg Pro Ile Leu Thr Ser Tyr His Phe Lys Thr Ala Leu Met His Leu 
        435                 440                 445             


Leu Leu Arg Leu Pro Leu Thr Asp Trp Ala His Asn Met Leu Ser Gln 
    450                 455                 460                 


Arg Leu Gln Asp Ile Leu Trp Phe Leu Gly Arg Gly Leu Gln Gln Arg 
465                 470                 475                 480 


Ser Leu His His Phe Leu Ile Gly Asn Asn Phe Leu Pro Leu Thr Ile 
                485                 490                 495     


Pro Ile Pro Lys Thr Phe Arg Asn Ala Glu Pro Val Asn Leu Phe Gln 
            500                 505                 510         


His Leu Val Leu Asn Pro Lys Ala His Ser Gln Ala Val Glu Glu Phe 
        515                 520                 525             


Gln Asn Leu Leu Thr Gln Val Lys Thr Leu Pro His Ala Pro Leu Ala 
    530                 535                 540                 


Ala Ala Pro 
545         


<210>  2056
<211>  78
<212>  PRT
<213>  Homo sapiens

<400>  2056

Met Gln Pro Gln Glu Ser His Val His Tyr Ser Arg Trp Glu Asp Gly 
1               5                   10                  15      


Ser Arg Asp Gly Val Ser Leu Gly Ala Val Ser Ser Thr Glu Glu Ala 
            20                  25                  30          


Ser Arg Cys Arg Arg Ile Ser Gln Arg Leu Cys Thr Gly Lys Leu Gly 
        35                  40                  45              


Ile Ala Met Lys Val Leu Gly Gly Val Ala Leu Phe Trp Ile Ile Phe 
    50                  55                  60                  


Ile Leu Gly Tyr Leu Thr Gly Tyr Tyr Val His Lys Cys Lys 
65                  70                  75              


<210>  2057
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  2057

Met Glu Arg Cys Ser Arg Cys His Arg Leu Leu Leu Leu Leu Pro Leu 
1               5                   10                  15      


Val Leu Gly Leu Ser Ala Ala Pro Gly Trp Ala Gly Ala Pro Pro Val 
            20                  25                  30          


Asp Val Leu Arg Ala Leu Arg Phe Pro Ser Leu Pro Asp Gly Val Arg 
        35                  40                  45              


Arg Ala Lys Gly Ile Cys Pro Ala Asp Val Ala Tyr Arg Val Ala Arg 
    50                  55                  60                  


Pro Ala Gln Leu Ser Ala Pro Thr Arg Gln Leu Phe Pro Gly Gly Phe 
65                  70                  75                  80  


Pro Lys Asp Phe Ser Leu Leu Thr Val Val Arg Thr Arg Pro Gly Leu 
                85                  90                  95      


Gln Ala Pro Leu Leu Thr Leu Tyr Ser Ala Gln Gly Val Arg Gln Leu 
            100                 105                 110         


Gly Leu Glu Leu Gly Arg Pro Val Arg Phe Leu Tyr Glu Asp Gln Thr 
        115                 120                 125             


Gly Arg Pro Gln Pro Pro Ser Gln Pro Val Phe Arg Gly Leu Ser Leu 
    130                 135                 140                 


Ala Asp Gly Lys Trp His Arg Val Ala Val Ala Val Lys Gly Gln Ser 
145                 150                 155                 160 


Val Thr Leu Ile Val Asp Cys Lys Lys Arg Val Thr Arg Pro Leu Pro 
                165                 170                 175     


Arg Ser Ala Arg Pro Val Leu Asp Thr His Gly Val Ile Ile Phe Gly 
            180                 185                 190         


Ala Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Val Gln Glu Leu 
        195                 200                 205             


Ala Ile Val Pro Gly Val Gln Ala Ala Tyr Glu Ser Cys Glu Gln Lys 
    210                 215                 220                 


Glu Leu Glu Cys Glu Gly Gly Gln Arg Glu Arg Pro Gln Asn Gln Gln 
225                 230                 235                 240 


Pro His Arg Ala Gln Arg Ser Pro Gln Gln Gln Pro Ser Arg Leu His 
                245                 250                 255     


Arg Pro Gln Asn Gln Glu Pro Gln Ser Gln Val Arg Glu Leu Gly Glu 
            260                 265                 270         


Pro Pro Ser Ala Ala His Pro Arg Glu Gly Arg His Pro Gly Ile Ser 
        275                 280                 285             


Pro Pro 
    290 


<210>  2058
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  2058

Met Ala Ala Lys Ser Gln Pro Asn Ile Pro Lys Ala Lys Ser Leu Asp 
1               5                   10                  15      


Gly Val Thr Asn Asp Arg Thr Ala Ser Gln Gly Gln Trp Gly Arg Ala 
            20                  25                  30          


Trp Glu Val Asp Trp Phe Ser Leu Ala Ser Val Ile Phe Leu Leu Leu 
        35                  40                  45              


Phe Ala Pro Phe Ile Val Tyr Tyr Phe Ile Met Ala Cys Asp Gln Tyr 
    50                  55                  60                  


Ser Cys Ala Leu Thr Gly Pro Val Val Asp Ile Val Thr Gly His Ala 
65                  70                  75                  80  


Arg Leu Ser Asp Ile Trp Ala Lys Thr Pro Pro Ile Thr Arg Lys Ala 
                85                  90                  95      


Ala Gln Leu Tyr Thr Leu Trp Val Thr Phe Gln Val Leu Leu Tyr Thr 
            100                 105                 110         


Ser Leu Pro Asp Phe Cys His Lys Phe Leu Pro Gly Tyr Val Gly Gly 
        115                 120                 125             


Ile Gln Glu Gly Ala Val Thr Pro Ala Gly Val Val Asn Lys Tyr Gln 
    130                 135                 140                 


Ile Asn Gly Leu Gln Ala Trp Leu Leu Thr His Leu Leu Trp Phe Ala 
145                 150                 155                 160 


Asn Ala His Leu Leu Ser Trp Phe Ser Pro Thr Ile Ile Phe Asp Asn 
                165                 170                 175     


Trp Ile Pro Leu Leu Trp Cys Ala Asn Ile Leu Gly Tyr Ala Val Ser 
            180                 185                 190         


Thr Phe Ala Met Val Lys Gly Tyr Phe Phe Pro Thr Ser Ala Arg Asp 
        195                 200                 205             


Cys Lys Phe Thr Gly Asn Phe Phe Tyr Asn Tyr Met Met Gly Ile Glu 
    210                 215                 220                 


Phe Asn Pro Arg Ile Gly Lys Trp Phe Asp Phe Lys Leu Phe Phe Asn 
225                 230                 235                 240 


Gly Arg Pro Gly Ile Val Ala Trp Thr Leu Ile Asn Leu Ser Phe Ala 
                245                 250                 255     


Ala Lys Gln Arg Glu Leu His Ser His Val Thr Asn Ala Met Val Leu 
            260                 265                 270         


Val Asn Val Leu Gln Ala Ile Tyr Val Ile Asp Phe Phe Trp Asn Glu 
        275                 280                 285             


Thr Trp Tyr Leu Lys Thr Ile Asp Ile Cys His Asp His Phe Gly Trp 
    290                 295                 300                 


Tyr Leu Gly Trp Gly Asp Cys Val Trp Leu Pro Tyr Leu Tyr Thr Leu 
305                 310                 315                 320 


Gln Gly Leu Tyr Leu Val Tyr His Pro Val Gln Leu Ser Thr Pro His 
                325                 330                 335     


Ala Val Gly Val Leu Leu Leu Gly Leu Val Gly Tyr Tyr Ile Phe Arg 
            340                 345                 350         


Val Ala Asn His Gln Lys Asp Leu Phe Arg Arg Thr Asp Gly Arg Cys 
        355                 360                 365             


Leu Ile Trp Gly Arg Lys Pro Lys Val Ile Glu Cys Ser Tyr Thr Ser 
    370                 375                 380                 


Ala Asp Gly Gln Arg His His Ser Lys Leu Leu Val Ser Gly Phe Trp 
385                 390                 395                 400 


Gly Val Ala Arg His Phe Asn Tyr Val Gly Asp Leu Met Gly Ser Leu 
                405                 410                 415     


Ala Tyr Cys Leu Ala Cys Gly Gly Gly His Leu Leu Pro Tyr Phe Tyr 
            420                 425                 430         


Ile Ile Tyr Met Ala Ile Leu Leu Thr His Arg Cys Leu Arg Asp Glu 
        435                 440                 445             


His Arg Cys Ala Ser Lys Tyr Gly Arg Asp Trp Glu Arg Tyr Thr Ala 
    450                 455                 460                 


Ala Val Pro Tyr Arg Leu Leu Pro Gly Ile Phe 
465                 470                 475 


<210>  2059
<211>  867
<212>  PRT
<213>  Homo sapiens

<400>  2059

Met Asp Asn Pro Gln Ala Leu Pro Leu Phe Leu Leu Leu Ala Ser Leu 
1               5                   10                  15      


Val Gly Ile Leu Thr Leu Arg Ala Ser Ser Gly Leu Gln Gln Thr Asn 
            20                  25                  30          


Phe Ser Ser Ala Phe Ser Ser Asp Ser Lys Ser Ser Ser Gln Gly Leu 
        35                  40                  45              


Gly Val Glu Val Pro Ser Ile Lys Pro Pro Ser Trp Lys Val Pro Asp 
    50                  55                  60                  


Gln Phe Leu Asp Ser Lys Ala Ser Ala Gly Ile Ser Asp Ser Ser Trp 
65                  70                  75                  80  


Phe Pro Glu Ala Leu Ser Ser Asn Met Ser Gly Ser Phe Trp Ser Asn 
                85                  90                  95      


Val Ser Ala Glu Gly Gln Asp Leu Ser Pro Val Ser Pro Phe Ser Glu 
            100                 105                 110         


Thr Pro Gly Ser Glu Val Phe Pro Asp Ile Ser Asp Pro Gln Val Pro 
        115                 120                 125             


Ala Lys Asp Pro Lys Pro Ser Phe Thr Val Lys Thr Pro Ala Ser Asn 
    130                 135                 140                 


Ile Ser Thr Gln Val Ser His Thr Lys Leu Ser Val Glu Ala Pro Asp 
145                 150                 155                 160 


Ser Lys Phe Ser Pro Asp Asp Met Asp Leu Lys Leu Ser Ala Gln Ser 
                165                 170                 175     


Pro Glu Ser Lys Phe Ser Ala Glu Thr His Ser Ala Ala Ser Phe Pro 
            180                 185                 190         


Gln Gln Val Gly Gly Pro Leu Ala Val Leu Val Gly Thr Thr Ile Arg 
        195                 200                 205             


Leu Pro Leu Val Pro Ile Pro Asn Pro Gly Pro Pro Thr Ser Leu Val 
    210                 215                 220                 


Val Trp Arg Arg Gly Ser Lys Val Leu Ala Ala Gly Gly Leu Gly Pro 
225                 230                 235                 240 


Gly Ala Pro Leu Ile Ser Leu Asp Pro Ala His Arg Asp His Leu Arg 
                245                 250                 255     


Phe Asp Gln Ala Arg Gly Val Leu Glu Leu Ala Ser Ala Gln Leu Asp 
            260                 265                 270         


Asp Ala Gly Val Tyr Thr Ala Glu Val Ile Arg Ala Gly Val Ser Gln 
        275                 280                 285             


Gln Thr His Glu Phe Thr Val Gly Val Tyr Glu Pro Leu Pro Gln Leu 
    290                 295                 300                 


Ser Val Gln Pro Lys Ala Pro Glu Thr Glu Glu Gly Ala Ala Glu Leu 
305                 310                 315                 320 


Arg Leu Arg Cys Leu Gly Trp Gly Pro Gly Arg Gly Glu Leu Ser Trp 
                325                 330                 335     


Ser Arg Asp Gly Arg Ala Leu Glu Ala Ala Glu Ser Glu Gly Ala Glu 
            340                 345                 350         


Thr Pro Arg Met Arg Ser Glu Gly Asp Gln Leu Leu Ile Val Arg Pro 
        355                 360                 365             


Val Arg Ser Asp His Ala Arg Tyr Thr Cys Arg Val Arg Ser Pro Phe 
    370                 375                 380                 


Gly His Arg Glu Ala Ala Ala Asp Val Ser Val Phe Tyr Gly Pro Asp 
385                 390                 395                 400 


Pro Pro Thr Ile Thr Val Ser Ser Asp Arg Asp Ala Ala Pro Ala Arg 
                405                 410                 415     


Phe Val Thr Ala Gly Ser Asn Val Thr Leu Arg Cys Ala Ala Ala Ser 
            420                 425                 430         


Arg Pro Pro Ala Asp Ile Thr Trp Ser Leu Ala Asp Pro Ala Glu Ala 
        435                 440                 445             


Ala Val Pro Ala Gly Ser Arg Leu Leu Leu Pro Ala Val Gly Pro Gly 
    450                 455                 460                 


His Ala Gly Thr Tyr Ala Cys Leu Ala Ala Asn Pro Arg Thr Gly Arg 
465                 470                 475                 480 


Arg Arg Arg Ser Leu Leu Asn Leu Thr Val Ala Asp Leu Pro Pro Gly 
                485                 490                 495     


Ala Pro Gln Cys Ser Val Glu Gly Gly Pro Gly Asp Arg Ser Leu Arg 
            500                 505                 510         


Phe Arg Cys Ser Trp Pro Gly Gly Ala Pro Ala Ala Ser Leu Gln Phe 
        515                 520                 525             


Gln Gly Leu Pro Glu Gly Ile Arg Ala Gly Pro Val Ser Ser Val Leu 
    530                 535                 540                 


Leu Ala Ala Val Pro Ala His Pro Arg Leu Ser Gly Val Pro Ile Thr 
545                 550                 555                 560 


Cys Leu Ala Arg His Leu Val Ala Thr Arg Thr Cys Thr Val Thr Pro 
                565                 570                 575     


Glu Ala Pro Arg Glu Val Leu Leu His Pro Leu Val Ala Glu Thr Arg 
            580                 585                 590         


Leu Gly Glu Ala Glu Val Ala Leu Glu Ala Ser Gly Cys Pro Pro Pro 
        595                 600                 605             


Ser Arg Ala Ser Trp Ala Arg Glu Gly Arg Pro Leu Ala Pro Gly Gly 
    610                 615                 620                 


Gly Ser Arg Leu Arg Leu Ser Gln Asp Gly Arg Lys Leu His Ile Gly 
625                 630                 635                 640 


Asn Phe Ser Leu Asp Trp Asp Leu Gly Asn Tyr Ser Val Leu Cys Ser 
                645                 650                 655     


Gly Ala Leu Gly Ala Gly Gly Asp Gln Ile Thr Leu Ile Gly Pro Ser 
            660                 665                 670         


Ile Ser Ser Trp Arg Leu Gln Arg Ala Arg Asp Ala Ala Val Leu Thr 
        675                 680                 685             


Trp Asp Val Glu Arg Gly Ala Leu Ile Ser Ser Phe Glu Ile Gln Ala 
    690                 695                 700                 


Trp Pro Asp Gly Pro Ala Leu Gly Arg Thr Ser Thr Tyr Arg Asp Trp 
705                 710                 715                 720 


Val Ser Leu Leu Ile Leu Gly Pro Gln Glu Arg Ser Ala Val Val Pro 
                725                 730                 735     


Leu Pro Pro Arg Asn Pro Gly Thr Trp Thr Phe Arg Ile Leu Pro Ile 
            740                 745                 750         


Leu Gly Gly Gln Pro Gly Thr Pro Ser Gln Ser Arg Val Tyr Arg Ala 
        755                 760                 765             


Gly Pro Thr Leu Ser His Gly Ala Ile Ala Gly Ile Val Leu Gly Ser 
    770                 775                 780                 


Leu Leu Gly Leu Ala Leu Leu Ala Val Leu Leu Leu Leu Cys Ile Cys 
785                 790                 795                 800 


Cys Leu Cys Arg Phe Arg Gly Lys Thr Pro Glu Lys Lys Lys His Pro 
                805                 810                 815     


Ser Thr Leu Val Pro Val Val Thr Pro Ser Glu Lys Lys Met His Ser 
            820                 825                 830         


Val Thr Pro Val Glu Ile Ser Trp Pro Leu Asp Leu Lys Val Pro Leu 
        835                 840                 845             


Glu Asp His Ser Ser Thr Arg Ala Tyr Gln Ala Gln Thr Pro Val Gln 
    850                 855                 860                 


Leu Ser Leu 
865         


<210>  2060
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  2060

Met Leu Ala Pro Gly Ser Ser Pro Gly Gln Arg Gly Arg Leu Ala Leu 
1               5                   10                  15      


Gln Trp Arg Gln Val Ser Trp Ile Thr Cys Trp Ile Ala Leu Tyr Ala 
            20                  25                  30          


Val Glu Ala Leu Pro Thr Cys Pro Phe Ser Cys Lys Cys Asp Ser Arg 
        35                  40                  45              


Ser Leu Glu Val Asp Cys Ser Gly Leu Gly Leu Thr Thr Val Pro Pro 
    50                  55                  60                  


Asp Val Pro Ala Ala Thr Arg Thr Leu Leu Leu Leu Asn Asn Lys Leu 
65                  70                  75                  80  


Ser Ala Leu Pro Ser Trp Ala Phe Ala Asn Leu Ser Ser Leu Gln Arg 
                85                  90                  95      


Leu Asp Leu Ser Asn Asn Phe Leu Asp Arg Leu Pro Arg Ser Ile Phe 
            100                 105                 110         


Gly Asp Leu Thr Asn Leu Thr Glu Leu Gln Leu Arg Asn Asn Ser Ile 
        115                 120                 125             


Arg Thr Leu Asp Arg Asp Leu Leu Arg His Ser Pro Leu Leu Arg His 
    130                 135                 140                 


Leu Asp Leu Ser Ile Asn Gly Leu Ala Gln Leu Pro Pro Gly Leu Phe 
145                 150                 155                 160 


Asp Gly Leu Leu Ala Leu Arg Ser Leu Ser Leu Arg Ser Asn Arg Leu 
                165                 170                 175     


Gln Asn Leu Asp Arg Leu Thr Phe Glu Pro Leu Ala Asn Leu Gln Leu 
            180                 185                 190         


Leu Gln Val Gly Asp Asn Pro Trp Glu Cys Asp Cys Asn Leu Arg Glu 
        195                 200                 205             


Phe Lys His Trp Met Glu Trp Phe Ser Tyr Arg Gly Gly Arg Leu Asp 
    210                 215                 220                 


Gln Leu Ala Cys Thr Leu Pro Lys Glu Leu Arg Gly Lys Asp Met Arg 
225                 230                 235                 240 


Met Val Pro Met Glu Met Phe Asn Tyr Cys Ser Gln Leu Glu Asp Glu 
                245                 250                 255     


Asn Ser Ser Ala Gly Leu Asp Ile Pro Gly Pro Pro Cys Thr Lys Ala 
            260                 265                 270         


Ser Pro Glu Pro Ala Lys Pro Lys Pro Gly Ala Glu Pro Glu Pro Glu 
        275                 280                 285             


Pro Ser Thr Ala Cys Pro Gln Lys Gln Arg His Arg Pro Ala Ser Val 
    290                 295                 300                 


Arg Arg Ala Met Gly Thr Val Ile Ile Ala Gly Val Val Cys Gly Val 
305                 310                 315                 320 


Val Cys Ile Met Met Val Val Ala Ala Ala Tyr Gly Cys Ile Tyr Ala 
                325                 330                 335     


Ser Leu Met Ala Lys Tyr His Arg Glu Leu Lys Lys Arg Gln Pro Leu 
            340                 345                 350         


Met Gly Asp Pro Glu Gly Glu His Glu Asp Gln Lys Gln Ile Ser Ser 
        355                 360                 365             


Val Ala 
    370 


<210>  2061
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  2061

Met Leu Ala Pro Gly Ser Ser Pro Gly Gln Arg Gly Arg Leu Ala Leu 
1               5                   10                  15      


Gln Trp Arg Gln Val Ser Trp Ile Thr Cys Trp Ile Ala Leu Tyr Ala 
            20                  25                  30          


Val Glu Ala Leu Pro Thr Cys Pro Phe Ser Cys Lys Cys Asp Ser Arg 
        35                  40                  45              


Ser Leu Glu Val Asp Cys Ser Gly Leu Gly Leu Thr Thr Val Pro Pro 
    50                  55                  60                  


Asp Val Pro Ala Ala Thr Arg Thr Leu Leu Leu Leu Asn Asn Lys Leu 
65                  70                  75                  80  


Ser Ala Leu Pro Ser Trp Ala Phe Ala Asn Leu Ser Ser Leu Gln Arg 
                85                  90                  95      


Leu Asp Leu Ser Asn Asn Phe Leu Asp Arg Leu Pro Arg Ser Ile Phe 
            100                 105                 110         


Gly Asp Leu Thr Asn Leu Thr Glu Leu Gln Leu Arg Asn Asn Ser Ile 
        115                 120                 125             


Arg Thr Leu Asp Arg Asp Leu Leu Arg His Ser Pro Leu Leu Arg His 
    130                 135                 140                 


Leu Asp Leu Ser Ile Asn Gly Leu Ala Gln Leu Pro Pro Gly Leu Phe 
145                 150                 155                 160 


Asp Gly Leu Leu Ala Leu Arg Ser Leu Ser Leu Arg Ser Asn Arg Leu 
                165                 170                 175     


Gln Asn Leu Asp Arg Leu Thr Phe Glu Pro Leu Ala Asn Leu Gln Leu 
            180                 185                 190         


Leu Gln Val Gly Asp Asn Pro Trp Glu Cys Asp Cys Asn Leu Arg Glu 
        195                 200                 205             


Phe Lys His Trp Met Glu Trp Phe Ser Tyr Arg Gly Gly Arg Leu Asp 
    210                 215                 220                 


Gln Leu Ala Cys Thr Leu Pro Lys Glu Leu Arg Gly Lys Asp Met Arg 
225                 230                 235                 240 


Met Val Pro Met Glu Met Phe Asn Tyr Cys Ser Gln Leu Glu Asp Glu 
                245                 250                 255     


Asn Ser Ser Ala Gly Leu Asp Ile Pro Gly Pro Pro Cys Thr Lys Ala 
            260                 265                 270         


Ser Pro Glu Pro Ala Lys Pro Lys Pro Gly Ala Glu Pro Glu Pro Glu 
        275                 280                 285             


Pro Ser Thr Ala Cys Pro Gln Lys Gln Arg His Arg Pro Ala Ser Val 
    290                 295                 300                 


Arg Arg Ala Met Gly Thr Val Ile Ile Ala Gly Val Val Cys Gly Val 
305                 310                 315                 320 


Val Cys Ile Met Met Val Val Ala Ala Ala Tyr Gly Cys Ile Tyr Ala 
                325                 330                 335     


Ser Leu Met Ala Lys Tyr His Arg Glu Leu Lys Lys Arg Gln Pro Leu 
            340                 345                 350         


Met Gly Asp Pro Glu Gly Glu His Glu Asp Gln Lys Gln Ile Ser Ser 
        355                 360                 365             


Val Ala 
    370 


<210>  2062
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  2062

Met Gly Arg Glu Glu Leu Phe Leu Thr Phe Ser Phe Ser Ser Gly Phe 
1               5                   10                  15      


Gln Glu Ser Asn Val Lys Thr Phe Cys Ser Lys Asn Ile Leu Ala Ile 
            20                  25                  30          


Leu Gly Phe Ser Ser Ile Ile Ala Val Ile Ala Leu Leu Ala Val Gly 
        35                  40                  45              


Leu Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val 
    50                  55                  60                  


Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro 
65                  70                  75                  80  


Ala Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys 
                85                  90                  95      


Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu 
            100                 105                 110         


Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile 
        115                 120                 125             


Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala 
    130                 135                 140                 


Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val 
145                 150                 155                 160 


Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln 
                165                 170                 175     


Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile 
            180                 185                 190         


Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Thr Arg Trp Phe 
        195                 200                 205             


Ser Ile Val Pro Tyr Glu Thr Asn Asn Gln Glu Thr Phe Gly Ala Leu 
    210                 215                 220                 


Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro Gln Asn Gln 
225                 230                 235                 240 


Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu Tyr Gly Lys 
                245                 250                 255     


Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly Lys Asp Gln 
            260                 265                 270         


Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala Ser Asn Glu 
        275                 280                 285             


Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys Val Val Asn 
    290                 295                 300                 


Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe Glu Met Thr 
305                 310                 315                 320 


Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn Tyr Gln Gln 
                325                 330                 335     


Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr Cys Pro Tyr 
            340                 345                 350         


Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu Gln Gly Asp 
        355                 360                 365             


Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe Leu Asn Leu 
    370                 375                 380                 


Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met Met Lys Lys 
385                 390                 395                 400 


Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr Ala Gly Val 
                405                 410                 415     


Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr Tyr Ile Leu 
            420                 425                 430         


Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser Trp Glu His 
        435                 440                 445             


Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly Trp Thr Leu 
    450                 455                 460                 


Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu Gln Pro Leu 
465                 470                 475                 480 


Ser Thr Pro Leu Ser His Ser Thr Tyr Val Phe Leu Met Val Leu Phe 
                485                 490                 495     


Ser Leu Val Leu Phe Thr Val Ala Ile Ile Gly Leu Leu Ile Phe His 
            500                 505                 510         


Lys Pro Ser Tyr Phe Trp Lys Asp Met Val 
        515                 520         


<210>  2063
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  2063

Met Glu Asp Thr Lys Glu Ser Asn Val Lys Thr Phe Cys Ser Lys Asn 
1               5                   10                  15      


Ile Leu Ala Ile Leu Gly Phe Ser Ser Ile Ile Ala Val Ile Ala Leu 
            20                  25                  30          


Leu Ala Val Gly Leu Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys 
        35                  40                  45              


Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile 
    50                  55                  60                  


Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val His Gln 
65                  70                  75                  80  


Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln 
                85                  90                  95      


Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala 
            100                 105                 110         


Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu 
        115                 120                 125             


Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu 
    130                 135                 140                 


Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro 
145                 150                 155                 160 


Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala 
                165                 170                 175     


Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys 
            180                 185                 190         


Thr Arg Trp Phe Ser Ile Val Pro Tyr Glu Thr Asn Asn Gln Glu Thr 
        195                 200                 205             


Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val 
    210                 215                 220                 


Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg 
225                 230                 235                 240 


Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr 
                245                 250                 255     


Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Gln 
            260                 265                 270         


Phe Glu Ile Gln Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile 
        275                 280                 285             


Leu Glu Leu Phe Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe 
    290                 295                 300                 


Asn Gly Ile Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser 
305                 310                 315                 320 


Ala Phe Tyr Phe Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val 
                325                 330                 335     


Ser Gln Glu Lys Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro 
            340                 345                 350         


Trp Glu Glu Ile Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu 
        355                 360                 365             


Ser Glu Tyr Cys Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln 
    370                 375                 380                 


Gly Tyr His Phe Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly 
385                 390                 395                 400 


Lys Ile Gln Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn 
                405                 410                 415     


Leu Thr Asn Met Ile Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser 
            420                 425                 430         


His Ser Thr Tyr Val Phe Leu Met Val Leu Phe Ser Leu Val Leu Phe 
        435                 440                 445             


Thr Val Ala Ile Ile Gly Leu Leu Ile Phe His Lys Pro Ser Tyr Phe 
    450                 455                 460                 


Trp Lys Asp Met Val 
465                 


<210>  2064
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  2064

Met Glu Arg Ala Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr 
1               5                   10                  15      


Pro Val Tyr Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu 
            20                  25                  30          


Ser Glu Glu Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu 
        35                  40                  45              


Ser Asn Tyr Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln 
    50                  55                  60                  


Glu Glu Gly Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys 
65                  70                  75                  80  


Phe Ser Gln Lys Thr Arg Trp Phe Ser Ile Val Pro Tyr Glu Thr Asn 
                85                  90                  95      


Asn Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln 
            100                 105                 110         


Val Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala 
        115                 120                 125             


Leu Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser 
    130                 135                 140                 


Phe Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys 
145                 150                 155                 160 


Asp Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His 
                165                 170                 175     


Pro Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro 
            180                 185                 190         


Cys Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile 
        195                 200                 205             


Gln Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu 
    210                 215                 220                 


Phe Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile 
225                 230                 235                 240 


Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr 
                245                 250                 255     


Phe Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu 
            260                 265                 270         


Lys Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu 
        275                 280                 285             


Ile Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr 
    290                 295                 300                 


Cys Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His 
305                 310                 315                 320 


Phe Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile Gln 
                325                 330                 335     


Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn 
            340                 345                 350         


Met Ile Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr 
        355                 360                 365             


Tyr Val Phe Leu Met Val Leu Phe Ser Leu Val Leu Phe Thr Val Ala 
    370                 375                 380                 


Ile Ile Gly Leu Leu Ile Phe His Lys Pro Ser Tyr Phe Trp Lys Asp 
385                 390                 395                 400 


Met Val 
        


<210>  2065
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  2065

Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg 
1               5                   10                  15      


Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr 
            20                  25                  30          


Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu 
        35                  40                  45              


Gly Lys Phe Ser Gln Lys Thr Arg Trp Phe Ser Ile Val Pro Tyr Glu 
    50                  55                  60                  


Thr Asn Asn Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser 
65                  70                  75                  80  


Thr Gln Val Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp 
                85                  90                  95      


Asn Ala Leu Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr 
            100                 105                 110         


His Ser Phe Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu 
        115                 120                 125             


Ala Lys Asp Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys 
    130                 135                 140                 


Phe His Pro Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys 
145                 150                 155                 160 


Thr Pro Cys Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe 
                165                 170                 175     


Glu Ile Gln Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu 
            180                 185                 190         


Glu Leu Phe Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn 
        195                 200                 205             


Gly Ile Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala 
    210                 215                 220                 


Phe Tyr Phe Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser 
225                 230                 235                 240 


Gln Glu Lys Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp 
                245                 250                 255     


Glu Glu Ile Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser 
            260                 265                 270         


Glu Tyr Cys Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly 
        275                 280                 285             


Tyr His Phe Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys 
    290                 295                 300                 


Ile Gln Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu 
305                 310                 315                 320 


Thr Asn Met Ile Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser His 
                325                 330                 335     


Ser Thr Tyr Val Phe Leu Met Val Leu Phe Ser Leu Val Leu Phe Thr 
            340                 345                 350         


Val Ala Ile Ile Gly Leu Leu Ile Phe His Lys Pro Ser Tyr Phe Trp 
        355                 360                 365             


Lys Asp Met Val 
    370         


<210>  2066
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  2066

Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg 
1               5                   10                  15      


Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr 
            20                  25                  30          


Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu 
        35                  40                  45              


Gly Lys Phe Ser Gln Lys Thr Arg Trp Phe Ser Ile Val Pro Tyr Glu 
    50                  55                  60                  


Thr Asn Asn Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser 
65                  70                  75                  80  


Thr Gln Val Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp 
                85                  90                  95      


Asn Ala Leu Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr 
            100                 105                 110         


His Ser Phe Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu 
        115                 120                 125             


Ala Lys Asp Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys 
    130                 135                 140                 


Phe His Pro Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys 
145                 150                 155                 160 


Thr Pro Cys Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe 
                165                 170                 175     


Glu Ile Gln Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu 
            180                 185                 190         


Glu Leu Phe Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn 
        195                 200                 205             


Gly Ile Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala 
    210                 215                 220                 


Phe Tyr Phe Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser 
225                 230                 235                 240 


Gln Glu Lys Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp 
                245                 250                 255     


Glu Glu Ile Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser 
            260                 265                 270         


Glu Tyr Cys Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly 
        275                 280                 285             


Tyr His Phe Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys 
    290                 295                 300                 


Ile Gln Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu 
305                 310                 315                 320 


Thr Asn Met Ile Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser His 
                325                 330                 335     


Ser Thr Tyr Val Phe Leu Met Val Leu Phe Ser Leu Val Leu Phe Thr 
            340                 345                 350         


Val Ala Ile Ile Gly Leu Leu Ile Phe His Lys Pro Ser Tyr Phe Trp 
        355                 360                 365             


Lys Asp Met Val 
    370         


<210>  2067
<211>  763
<212>  PRT
<213>  Homo sapiens

<400>  2067

Met Ala Thr Pro Gly Ser Glu Pro Gln Pro Phe Val Pro Ala Leu Ser 
1               5                   10                  15      


Val Ala Thr Leu His Pro Leu His His Pro His His His His His His 
            20                  25                  30          


His Gln His His Gly Gly Thr Gly Ala Pro Gly Gly Ala Gly Gly Gly 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Phe Asn Leu Pro Leu Asn Arg Gly Leu Glu 
    50                  55                  60                  


Arg Ala Leu Glu Glu Ala Ala Asn Ser Gly Gly Leu Asn Leu Ser Ala 
65                  70                  75                  80  


Arg Lys Leu Lys Glu Phe Pro Arg Thr Ala Ala Pro Gly His Asp Leu 
                85                  90                  95      


Ser Asp Thr Val Gln Ala Asp Leu Ser Lys Asn Arg Leu Val Glu Val 
            100                 105                 110         


Pro Met Glu Leu Cys His Phe Val Ser Leu Glu Ile Leu Asn Leu Tyr 
        115                 120                 125             


His Asn Cys Ile Arg Val Ile Pro Glu Ala Ile Val Asn Leu Gln Met 
    130                 135                 140                 


Leu Thr Tyr Leu Asn Leu Ser Arg Asn Gln Leu Ser Ala Leu Pro Ala 
145                 150                 155                 160 


Cys Leu Cys Gly Leu Pro Leu Lys Val Leu Ile Ala Ser Asn Asn Lys 
                165                 170                 175     


Leu Gly Ser Leu Pro Glu Glu Ile Gly Gln Leu Lys Gln Leu Met Glu 
            180                 185                 190         


Leu Asp Val Ser Cys Asn Glu Ile Thr Ala Leu Pro Gln Gln Ile Gly 
        195                 200                 205             


Gln Leu Lys Ser Leu Arg Glu Leu Asn Val Arg Arg Asn Tyr Leu Lys 
    210                 215                 220                 


Val Leu Pro Gln Glu Leu Val Asp Leu Pro Leu Val Lys Phe Asp Phe 
225                 230                 235                 240 


Ser Cys Asn Lys Val Leu Val Ile Pro Ile Cys Phe Arg Glu Met Lys 
                245                 250                 255     


Gln Leu Gln Val Leu Leu Leu Glu Asn Asn Pro Leu Gln Ser Pro Pro 
            260                 265                 270         


Ala Gln Ile Cys Thr Lys Gly Lys Val His Ile Phe Lys Tyr Leu Ser 
        275                 280                 285             


Ile Gln Ala Cys Gln Ile Lys Thr Ala Asp Ser Leu Tyr Leu His Thr 
    290                 295                 300                 


Met Glu Arg Pro His Leu His Gln His Val Glu Asp Gly Lys Lys Asp 
305                 310                 315                 320 


Ser Asp Ser Gly Val Gly Ser Asp Asn Gly Asp Lys Arg Leu Ser Ala 
                325                 330                 335     


Thr Glu Pro Ser Asp Glu Asp Thr Val Ser Leu Asn Val Pro Met Ser 
            340                 345                 350         


Asn Ile Met Glu Glu Glu Gln Ile Ile Lys Glu Asp Ser Cys His Arg 
        355                 360                 365             


Leu Ser Pro Val Lys Gly Glu Phe His Gln Glu Phe Gln Pro Glu Pro 
    370                 375                 380                 


Ser Leu Leu Gly Asp Ser Thr Asn Ser Gly Glu Glu Arg Asp Gln Phe 
385                 390                 395                 400 


Thr Asp Arg Ala Asp Gly Leu His Ser Glu Phe Met Asn Tyr Lys Ala 
                405                 410                 415     


Arg Ala Glu Asp Cys Glu Glu Leu Leu Arg Ile Glu Glu Asp Val His 
            420                 425                 430         


Trp Gln Thr Glu Gly Ile Ile Ser Ser Ser Lys Asp Gln Asp Met Asp 
        435                 440                 445             


Ile Ala Met Ile Glu Gln Leu Arg Glu Ala Val Asp Leu Leu Gln Asp 
    450                 455                 460                 


Pro Asn Gly Leu Ser Thr Asp Ile Thr Glu Arg Ser Val Leu Asn Leu 
465                 470                 475                 480 


Tyr Pro Met Gly Ser Ala Glu Ala Leu Glu Leu Gln Asp Ser Ala Leu 
                485                 490                 495     


Asn Gly Gln Ile Gln Leu Glu Thr Ser Pro Val Cys Glu Val Gln Ser 
            500                 505                 510         


Asp Leu Thr Leu Gln Ser Asn Gly Ser Gln Tyr Ser Pro Asn Glu Ile 
        515                 520                 525             


Arg Glu Asn Ser Pro Ala Val Ser Pro Thr Thr Asn Ser Thr Ala Pro 
    530                 535                 540                 


Phe Gly Leu Lys Pro Arg Ser Asp Pro Ala Leu Ile Leu Pro Pro Ile 
545                 550                 555                 560 


Ser Phe Asn Thr Leu Thr Gln Ala Gln Thr Trp Asp Ser Ser Ser Tyr 
                565                 570                 575     


Ser Val Pro Ser Glu Gly Asp Ser Asp Asn Val Phe Leu Arg Pro Gln 
            580                 585                 590         


Arg Asn Leu Glu Ser Ile Asp Pro Gln Phe Thr Ile Arg Arg Lys Met 
        595                 600                 605             


Glu Gln Met Arg Glu Glu Lys Glu Leu Val Glu Gln Leu Arg Glu Ser 
    610                 615                 620                 


Ile Glu Met Arg Leu Lys Val Ser Leu His Glu Asp Leu Gly Ala Ala 
625                 630                 635                 640 


Leu Met Asp Gly Val Val Leu Cys His Leu Val Asn His Ile Arg Pro 
                645                 650                 655     


Arg Ser Val Ala Ser Ile His Val Pro Ser Pro Ala Val Pro Lys Leu 
            660                 665                 670         


Ser Met Ala Lys Cys Arg Arg Asn Val Glu Asn Phe Leu Glu Ala Cys 
        675                 680                 685             


Arg Lys Leu Gly Val Pro Glu Ala Asp Leu Cys Ser Pro Cys Asp Ile 
    690                 695                 700                 


Leu Gln Leu Asp Phe Arg His Ile Arg Lys Thr Val Asp Thr Leu Leu 
705                 710                 715                 720 


Ala Leu Gly Glu Lys Ala Pro Pro Pro Thr Ser Ala Leu Arg Ser Arg 
                725                 730                 735     


Asp Leu Ile Gly Phe Cys Leu Val His Ile Leu Phe Ile Val Leu Val 
            740                 745                 750         


Tyr Ile Thr Tyr His Trp Asn Ala Leu Ser Ala 
        755                 760             


<210>  2068
<211>  696
<212>  PRT
<213>  Homo sapiens

<400>  2068

Met Ala Thr Pro Gly Ser Glu Pro Gln Pro Phe Val Pro Ala Leu Ser 
1               5                   10                  15      


Val Ala Thr Leu His Pro Leu His His Pro His His His His His His 
            20                  25                  30          


His Gln His His Gly Gly Thr Gly Ala Pro Gly Gly Ala Gly Gly Gly 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Phe Asn Leu Pro Leu Asn Arg Gly Leu Glu 
    50                  55                  60                  


Arg Ala Leu Glu Glu Ala Ala Asn Ser Gly Gly Leu Asn Leu Ser Ala 
65                  70                  75                  80  


Arg Lys Leu Lys Glu Phe Pro Arg Thr Ala Ala Pro Gly His Asp Leu 
                85                  90                  95      


Ser Asp Thr Val Gln Ala Asp Leu Ser Lys Asn Arg Leu Val Glu Val 
            100                 105                 110         


Pro Met Glu Leu Cys His Phe Val Ser Leu Glu Ile Leu Asn Leu Tyr 
        115                 120                 125             


His Asn Cys Ile Arg Val Ile Pro Glu Ala Ile Val Asn Leu Gln Met 
    130                 135                 140                 


Leu Thr Tyr Leu Asn Leu Ser Arg Asn Gln Leu Ser Ala Leu Pro Ala 
145                 150                 155                 160 


Cys Leu Cys Gly Leu Pro Leu Lys Val Leu Ile Ala Ser Asn Asn Lys 
                165                 170                 175     


Leu Gly Ser Leu Pro Glu Glu Ile Gly Gln Leu Lys Gln Leu Met Glu 
            180                 185                 190         


Leu Asp Val Ser Cys Asn Glu Ile Thr Ala Leu Pro Gln Gln Ile Gly 
        195                 200                 205             


Gln Leu Lys Ser Leu Arg Glu Leu Asn Val Arg Arg Asn Tyr Leu Lys 
    210                 215                 220                 


Val Leu Pro Gln Glu Leu Val Asp Leu Pro Leu Val Lys Phe Asp Phe 
225                 230                 235                 240 


Ser Cys Asn Lys Val Leu Val Ile Pro Ile Cys Phe Arg Glu Met Lys 
                245                 250                 255     


Gln Leu Gln Val Leu Leu Leu Glu Asn Asn Pro Leu Gln Ser Pro Pro 
            260                 265                 270         


Ala Gln Ile Cys Thr Lys Gly Lys Val His Ile Phe Lys Tyr Leu Ser 
        275                 280                 285             


Ile Gln Ala Cys Gln Ile Lys Thr Ala Asp Ser Leu Tyr Leu His Thr 
    290                 295                 300                 


Met Glu Arg Pro His Leu His Gln His Val Glu Asp Gly Lys Lys Asp 
305                 310                 315                 320 


Ser Asp Ser Gly Val Gly Ser Asp Asn Gly Asp Lys Arg Leu Ser Ala 
                325                 330                 335     


Thr Glu Pro Ser Asp Glu Asp Thr Val Ser Leu Asn Val Pro Met Ser 
            340                 345                 350         


Asn Ile Met Glu Glu Glu Gln Ile Ile Lys Glu Asp Ser Cys His Arg 
        355                 360                 365             


Leu Ser Pro Val Lys Gly Glu Phe His Gln Glu Phe Gln Pro Glu Pro 
    370                 375                 380                 


Ser Leu Leu Gly Asp Ser Thr Asn Ser Gly Glu Glu Arg Asp Gln Phe 
385                 390                 395                 400 


Thr Asp Arg Ala Asp Gly Leu His Ser Glu Phe Met Asn Tyr Lys Ala 
                405                 410                 415     


Arg Ala Glu Asp Cys Glu Glu Leu Leu Arg Ile Glu Glu Asp Val His 
            420                 425                 430         


Trp Gln Thr Glu Gly Ile Ile Ser Ser Ser Lys Asp Gln Asp Met Asp 
        435                 440                 445             


Ile Ala Met Ile Glu Gln Leu Arg Glu Ala Val Asp Leu Leu Gln Asp 
    450                 455                 460                 


Pro Asn Gly Leu Ser Thr Asp Ile Thr Glu Arg Ser Val Leu Asn Leu 
465                 470                 475                 480 


Tyr Pro Met Gly Ser Ala Glu Ala Leu Glu Leu Gln Asp Ser Ala Leu 
                485                 490                 495     


Asn Gly Gln Ile Gln Leu Glu Thr Ser Pro Val Cys Glu Val Gln Ser 
            500                 505                 510         


Asp Leu Thr Leu Gln Ser Asn Gly Ser Gln Tyr Ser Pro Asn Glu Ile 
        515                 520                 525             


Arg Glu Asn Ser Pro Ala Val Ser Pro Thr Thr Asn Ser Thr Ala Pro 
    530                 535                 540                 


Phe Gly Leu Lys Pro Arg Ser Val Phe Leu Arg Pro Gln Arg Asn Leu 
545                 550                 555                 560 


Glu Ser Ile Asp Pro Gln Phe Thr Ile Arg Arg Lys Met Glu Gln Met 
                565                 570                 575     


Arg Glu Glu Lys Glu Leu Val Glu Gln Leu Arg Glu Ser Ile Glu Met 
            580                 585                 590         


Arg Leu Lys Val Ser Leu His Glu Asp Leu Gly Ala Ala Leu Met Asp 
        595                 600                 605             


Gly Val Val Leu Cys His Leu Val Asn His Ile Arg Pro Arg Ser Val 
    610                 615                 620                 


Ala Ser Ile His Val Pro Ser Pro Ala Val Pro Lys Leu Ser Met Ala 
625                 630                 635                 640 


Lys Cys Arg Arg Asn Val Glu Asn Phe Leu Glu Ala Cys Arg Lys Leu 
                645                 650                 655     


Gly Val Pro Glu Glu Lys Leu Cys Leu Pro His His Ile Leu Glu Glu 
            660                 665                 670         


Lys Gly Leu Val Lys Val Gly Ile Thr Ile Gln Ala Leu Leu Asp Ile 
        675                 680                 685             


Thr Val Thr Lys Ala Leu Phe Thr 
    690                 695     


<210>  2069
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  2069

Met Leu Arg Pro Gln Gly Leu Leu Trp Leu Pro Leu Leu Phe Thr Ser 
1               5                   10                  15      


Val Cys Val Met Leu Asn Ser Asn Val Leu Leu Trp Ile Thr Ala Leu 
            20                  25                  30          


Ala Ile Lys Phe Thr Leu Ile Asp Ser Gln Ala Gln Tyr Pro Val Val 
        35                  40                  45              


Asn Thr Asn Tyr Gly Lys Ile Gln Gly Leu Arg Thr Pro Leu Pro Ser 
    50                  55                  60                  


Glu Ile Leu Gly Pro Val Glu Gln Tyr Leu Gly Val Pro Tyr Ala Ser 
65                  70                  75                  80  


Pro Pro Thr Gly Glu Arg Arg Phe Gln Pro Pro Glu Ser Pro Ser Ser 
                85                  90                  95      


Trp Thr Gly Ile Arg Asn Ala Thr Gln Phe Ser Ala Val Cys Pro Gln 
            100                 105                 110         


His Leu Asp Glu Arg Phe Leu Leu His Asp Met Leu Pro Ile Trp Phe 
        115                 120                 125             


Thr Thr Ser Leu Asp Thr Leu Met Thr Tyr Val Gln Asp Gln Asn Glu 
    130                 135                 140                 


Asp Cys Leu Tyr Leu Asn Ile Tyr Val Pro Met Glu Asp Gly Thr Asn 
145                 150                 155                 160 


Ile Lys Arg Asn Ala Asp Asp Ile Thr Ser Asn Asp His Gly Glu Asp 
                165                 170                 175     


Lys Asp Ile His Glu Gln Asn Ser Lys Lys Pro Val Met Val Tyr Ile 
            180                 185                 190         


His Gly Gly Ser Tyr Met Glu Gly Thr Gly Asn Met Ile Asp Gly Ser 
        195                 200                 205             


Ile Leu Ala Ser Tyr Gly Asn Val Ile Val Ile Thr Ile Asn Tyr Arg 
    210                 215                 220                 


Leu Gly Ile Leu Gly Met Gln Glu Ala Arg Leu Cys Gly Ser Ser Lys 
225                 230                 235                 240 


Met Phe Asn Tyr Phe Lys Ser Pro Phe Thr Asn Leu Ile Asn Phe Phe 
                245                 250                 255     


<210>  2070
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  2070

Met Gly Arg Thr Tyr Ile Val Glu Glu Thr Val Gly Gln Tyr Leu Ser 
1               5                   10                  15      


Asn Ile Asn Leu Gln Gly Lys Ala Phe Val Ser Gly Leu Leu Ile Gly 
            20                  25                  30          


Gln Cys Ser Ser Gln Lys Asp Tyr Val Ile Leu Ala Thr Arg Thr Pro 
        35                  40                  45              


Pro Lys Glu Glu Gln Ser Glu Asn Leu Lys His Pro Lys Ala Lys Leu 
    50                  55                  60                  


Asp Asn Leu Asp Glu Glu Trp Ala Thr Glu His Ala Cys Gln Val Ser 
65                  70                  75                  80  


Arg Met Leu Pro Gly Gly Leu Leu Val Leu Gly Val Phe Ile Ile Thr 
                85                  90                  95      


Thr Leu Glu Leu Ala Asn Asp Phe Gln Asn Ala Leu Arg Arg Leu Met 
            100                 105                 110         


Phe Ala Val Glu Lys Ser Ile Asn Arg Lys Arg Leu Trp Asn Phe Thr 
        115                 120                 125             


Glu Glu Glu Val Ser Glu Arg Val Thr Leu His Ile Cys Ala Ser Thr 
    130                 135                 140                 


Lys Lys Ile Phe Cys Arg Thr Tyr Asp Ile His Asp Pro Lys Ser Ser 
145                 150                 155                 160 


Ala Arg Pro Ala Asp Trp Lys Tyr Gln Ser Gly Leu Ser Ser Ser Trp 
                165                 170                 175     


Leu Ser Leu Glu Cys Thr Val His Ile Asn Ile His Ile Pro Leu Ser 
            180                 185                 190         


Ala Thr Ser Val Ser Tyr Thr Leu Glu Lys Asn Thr Lys Asn Gly Leu 
        195                 200                 205             


Thr Arg Trp Ala Lys Glu Ile Glu Asn Gly Val Tyr Leu Ile Asn Gly 
    210                 215                 220                 


Gln Val Lys Asp Glu Asp Cys Asp Leu Leu Glu Gly Gln Leu Leu Asn 
225                 230                 235                 240 


Ser Asp His Arg Ser Thr Ala Thr Val Gln Ile Cys Ser Gly Ser Val 
                245                 250                 255     


Asn Leu Lys Gly Ala Val Lys Cys Arg Ala Tyr Ile His Ser Ser Lys 
            260                 265                 270         


Pro Lys Val Lys Asp Ala Val Gln Ala Val Lys Arg Asp Ile Leu Asn 
        275                 280                 285             


Thr Val Ala Asp Arg Cys Glu Met Leu Phe Glu Asp Leu Leu Leu Asn 
    290                 295                 300                 


Glu Ile Pro Glu Lys Lys Asp Ser Glu Lys Glu Phe His Val Leu Pro 
305                 310                 315                 320 


Tyr Arg Val Phe Val Pro Leu Pro Gly Ser Thr Val Met Leu Cys Asp 
                325                 330                 335     


Tyr Lys Phe Asp Asp Glu Ser Ala Glu Glu Ile Arg Asp His Phe Met 
            340                 345                 350         


Glu Met Leu Asp His Thr Ile Gln Ile Glu Asp Leu Glu Ile Ala Glu 
        355                 360                 365             


Glu Thr Asn Thr Ala Cys Met Ser Ser Ser Met Asn Ser Gln Ala Ser 
    370                 375                 380                 


Leu Asp Asn Thr Asp Asp Glu Gln Pro Lys Gln Pro Ile Lys Thr Thr 
385                 390                 395                 400 


Met Leu Leu Lys Ile Gln Gln Asn Ile Gly Val Ile Ala Ala Phe Thr 
                405                 410                 415     


Val Ala Val Leu Ala Ala Gly Ile Ser Phe His Tyr Phe Ser Asp 
            420                 425                 430     


<210>  2071
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  2071

Met Gly Arg Thr Tyr Ile Val Glu Glu Thr Val Gly Gln Tyr Leu Ser 
1               5                   10                  15      


Asn Ile Asn Leu Gln Gly Lys Ala Phe Val Ser Gly Leu Leu Ile Gly 
            20                  25                  30          


Gln Cys Ser Ser Gln Lys Asp Tyr Val Ile Leu Ala Thr Arg Thr Pro 
        35                  40                  45              


Pro Lys Glu Glu Gln Ser Glu Asn Leu Lys His Pro Lys Ala Lys Leu 
    50                  55                  60                  


Asp Asn Leu Asp Glu Glu Trp Ala Thr Glu His Ala Cys Gln Leu Met 
65                  70                  75                  80  


Phe Ala Val Glu Lys Ser Ile Asn Arg Lys Arg Leu Trp Asn Phe Thr 
                85                  90                  95      


Glu Glu Glu Val Ser Glu Arg Val Thr Leu His Ile Cys Ala Ser Thr 
            100                 105                 110         


Lys Lys Ile Phe Cys Arg Thr Tyr Asp Ile His Asp Pro Lys Ser Ser 
        115                 120                 125             


Ala Arg Pro Ala Asp Trp Lys Tyr Gln Ser Gly Leu Ser Ser Ser Trp 
    130                 135                 140                 


Leu Ser Leu Glu Cys Thr Val His Ile Asn Ile His Ile Pro Leu Ser 
145                 150                 155                 160 


Ala Thr Ser Val Ser Tyr Thr Leu Glu Lys Asn Thr Lys Asn Gly Leu 
                165                 170                 175     


Thr Arg Trp Ala Lys Glu Ile Glu Asn Gly Val Tyr Leu Ile Asn Gly 
            180                 185                 190         


Gln Val Lys Asp Glu Asp Cys Asp Leu Leu Glu Gly Gln Lys Lys Ser 
        195                 200                 205             


Ser Arg Gly Asn Thr Gln Ala Thr Ser His Ser Phe Asp Val Arg Val 
    210                 215                 220                 


Leu Thr Gln Leu Leu Leu Asn Ser Asp His Arg Ser Thr Ala Thr Val 
225                 230                 235                 240 


Gln Ile Cys Ser Gly Ser Val Asn Leu Lys Gly Ala Val Lys Cys Arg 
                245                 250                 255     


Ala Tyr Ile His Ser Ser Lys Pro Lys Val Lys Asp Ala Val Gln Ala 
            260                 265                 270         


Val Lys Arg Asp Ile Leu Asn Thr Val Ala Asp Arg Cys Glu Met Leu 
        275                 280                 285             


Phe Glu Asp Leu Leu Leu Asn Glu Ile Pro Glu Lys Lys Asp Ser Glu 
    290                 295                 300                 


Lys Glu Phe His Val Leu Pro Tyr Arg Val Phe Val Pro Leu Pro Gly 
305                 310                 315                 320 


Ser Thr Val Met Leu Cys Asp Tyr Lys Phe Asp Asp Glu Ser Ala Glu 
                325                 330                 335     


Glu Ile Arg Asp His Phe Met Glu Met Leu Asp His Thr Ile Gln Ile 
            340                 345                 350         


Glu Asp Leu Glu Ile Ala Glu Glu Thr Asn Thr Ala Cys Met Ser Ser 
        355                 360                 365             


Ser Met Asn Ser Gln Ala Ser Leu Asp Asn Thr Asp Asp Glu Gln Pro 
    370                 375                 380                 


Lys Gln Pro Ile Lys Thr Thr Met Leu Leu Lys Ile Gln Gln Asn Ile 
385                 390                 395                 400 


Gly Val Ile Ala Ala Phe Thr Val Ala Val Leu Ala Ala Gly Ile Ser 
                405                 410                 415     


Phe His Tyr Phe Ser Asp 
            420         


<210>  2072
<211>  1139
<212>  PRT
<213>  Homo sapiens

<400>  2072

Met Asn Gly Gly Gln Cys Ser Ser Arg Asn Gln Cys Leu Cys Pro Pro 
1               5                   10                  15      


Asp Phe Thr Gly Arg Phe Cys Gln Val Pro Ala Gly Gly Ala Gly Gly 
            20                  25                  30          


Gly Thr Gly Gly Ser Gly Pro Gly Leu Ser Arg Thr Gly Ala Leu Ser 
        35                  40                  45              


Thr Gly Ala Leu Pro Pro Leu Ala Pro Glu Gly Asp Ser Val Ala Ser 
    50                  55                  60                  


Lys His Ala Ile Tyr Ala Val Gln Val Ile Ala Asp Pro Pro Gly Pro 
65                  70                  75                  80  


Gly Glu Gly Pro Pro Ala Gln His Ala Ala Phe Leu Val Pro Leu Gly 
                85                  90                  95      


Pro Gly Gln Ile Ser Ala Glu Val Gln Ala Pro Pro Pro Val Val Asn 
            100                 105                 110         


Val Arg Val His His Pro Pro Glu Ala Ser Val Gln Val His Arg Ile 
        115                 120                 125             


Glu Ser Ser Asn Ala Glu Ser Ala Ala Pro Ser Gln His Leu Leu Pro 
    130                 135                 140                 


His Pro Lys Pro Ser His Pro Arg Pro Pro Thr Gln Lys Pro Leu Gly 
145                 150                 155                 160 


Arg Cys Phe Gln Asp Thr Leu Pro Lys Gln Pro Cys Gly Ser Asn Pro 
                165                 170                 175     


Leu Pro Gly Leu Thr Lys Gln Glu Asp Cys Cys Gly Ser Ile Gly Thr 
            180                 185                 190         


Ala Trp Gly Gln Ser Lys Cys His Lys Cys Pro Gln Leu Gln Tyr Thr 
        195                 200                 205             


Gly Val Gln Lys Pro Gly Pro Val Arg Gly Glu Val Gly Ala Asp Cys 
    210                 215                 220                 


Pro Gln Gly Tyr Lys Arg Leu Asn Ser Thr His Cys Gln Asp Ile Asn 
225                 230                 235                 240 


Glu Cys Ala Met Pro Gly Val Cys Arg His Gly Asp Cys Leu Asn Asn 
                245                 250                 255     


Pro Gly Ser Tyr Arg Cys Val Cys Pro Pro Gly His Ser Leu Gly Pro 
            260                 265                 270         


Ser Arg Thr Gln Cys Ile Ala Asp Lys Pro Glu Glu Lys Ser Leu Cys 
        275                 280                 285             


Phe Arg Leu Val Ser Pro Glu His Gln Cys Gln His Pro Leu Thr Thr 
    290                 295                 300                 


Arg Leu Thr Arg Gln Leu Cys Cys Cys Ser Val Gly Lys Ala Trp Gly 
305                 310                 315                 320 


Ala Arg Cys Gln Arg Cys Pro Thr Asp Gly Thr Ala Ala Phe Lys Glu 
                325                 330                 335     


Ile Cys Pro Ala Gly Lys Gly Tyr His Ile Leu Thr Ser His Gln Thr 
            340                 345                 350         


Leu Thr Ile Gln Gly Glu Ser Asp Phe Ser Leu Phe Leu His Pro Asp 
        355                 360                 365             


Gly Pro Pro Lys Pro Gln Gln Leu Pro Glu Ser Pro Ser Gln Ala Pro 
    370                 375                 380                 


Pro Pro Glu Asp Thr Glu Glu Glu Arg Gly Val Thr Thr Asp Ser Pro 
385                 390                 395                 400 


Val Ser Glu Glu Arg Ser Val Gln Gln Ser His Pro Thr Ala Thr Thr 
                405                 410                 415     


Thr Pro Ala Arg Pro Tyr Pro Glu Leu Ile Ser Arg Pro Ser Pro Pro 
            420                 425                 430         


Thr Met Arg Trp Phe Leu Pro Asp Leu Pro Pro Ser Arg Ser Ala Val 
        435                 440                 445             


Glu Ile Ala Pro Thr Gln Val Thr Glu Thr Asp Glu Cys Arg Leu Asn 
    450                 455                 460                 


Gln Asn Ile Cys Gly His Gly Glu Cys Val Pro Gly Pro Pro Asp Tyr 
465                 470                 475                 480 


Ser Cys His Cys Asn Pro Gly Tyr Arg Ser His Pro Gln His Arg Tyr 
                485                 490                 495     


Cys Val Asp Val Asn Glu Cys Glu Ala Glu Pro Cys Gly Pro Gly Arg 
            500                 505                 510         


Gly Ile Cys Met Asn Thr Gly Gly Ser Tyr Asn Cys His Cys Asn Arg 
        515                 520                 525             


Gly Tyr Arg Leu His Val Gly Ala Gly Gly Arg Ser Cys Val Asp Leu 
    530                 535                 540                 


Asn Glu Cys Ala Lys Pro His Leu Cys Gly Asp Gly Gly Phe Cys Ile 
545                 550                 555                 560 


Asn Phe Pro Gly His Tyr Lys Cys Asn Cys Tyr Pro Gly Tyr Arg Leu 
                565                 570                 575     


Lys Ala Ser Arg Pro Pro Val Cys Glu Asp Ile Asp Glu Cys Arg Asp 
            580                 585                 590         


Pro Ser Ser Cys Pro Asp Gly Lys Cys Glu Asn Lys Pro Gly Ser Phe 
        595                 600                 605             


Lys Cys Ile Ala Cys Gln Pro Gly Tyr Arg Ser Gln Gly Gly Gly Ala 
    610                 615                 620                 


Cys Arg Asp Val Asn Glu Cys Ala Glu Gly Ser Pro Cys Ser Pro Gly 
625                 630                 635                 640 


Trp Cys Glu Asn Leu Pro Gly Ser Phe Arg Cys Thr Cys Ala Gln Gly 
                645                 650                 655     


Tyr Ala Pro Ala Pro Asp Gly Arg Ser Cys Leu Asp Val Asp Glu Cys 
            660                 665                 670         


Glu Ala Gly Asp Val Cys Asp Asn Gly Ile Cys Ser Asn Thr Pro Gly 
        675                 680                 685             


Ser Phe Gln Cys Gln Cys Leu Ser Gly Tyr His Leu Ser Arg Asp Arg 
    690                 695                 700                 


Ser His Cys Glu Asp Ile Asp Glu Cys Asp Phe Pro Ala Ala Cys Ile 
705                 710                 715                 720 


Gly Gly Asp Cys Ile Asn Thr Asn Gly Ser Tyr Arg Cys Leu Cys Pro 
                725                 730                 735     


Gln Gly His Arg Leu Val Gly Gly Arg Lys Cys Gln Asp Ile Asp Glu 
            740                 745                 750         


Cys Ser Gln Asp Pro Ser Leu Cys Leu Pro His Gly Ala Cys Lys Asn 
        755                 760                 765             


Leu Gln Gly Ser Tyr Val Cys Val Cys Asp Glu Gly Phe Thr Pro Thr 
    770                 775                 780                 


Gln Asp Gln His Gly Cys Glu Glu Val Glu Gln Pro His His Lys Lys 
785                 790                 795                 800 


Glu Cys Tyr Leu Asn Phe Asp Asp Thr Val Phe Cys Asp Ser Val Leu 
                805                 810                 815     


Ala Thr Asn Val Thr Gln Gln Glu Cys Cys Cys Ser Leu Gly Ala Gly 
            820                 825                 830         


Trp Gly Asp His Cys Glu Ile Tyr Pro Cys Pro Val Tyr Ser Ser Ala 
        835                 840                 845             


Glu Phe His Ser Leu Cys Pro Asp Gly Lys Gly Tyr Thr Gln Asp Asn 
    850                 855                 860                 


Asn Ile Val Asn Tyr Gly Ile Pro Ala His Arg Asp Ile Asp Glu Cys 
865                 870                 875                 880 


Met Leu Phe Gly Ser Glu Ile Cys Lys Glu Gly Lys Cys Val Asn Thr 
                885                 890                 895     


Gln Pro Gly Tyr Glu Cys Tyr Cys Lys Gln Gly Phe Tyr Tyr Asp Gly 
            900                 905                 910         


Asn Leu Leu Glu Cys Val Asp Val Asp Glu Cys Leu Asp Glu Ser Asn 
        915                 920                 925             


Cys Arg Asn Gly Val Cys Glu Asn Thr Arg Gly Gly Tyr Arg Cys Ala 
    930                 935                 940                 


Cys Thr Pro Pro Ala Glu Tyr Ser Pro Ala Gln Arg Gln Cys Leu Ser 
945                 950                 955                 960 


Pro Glu Glu Met Glu Arg Ala Pro Glu Arg Arg Asp Val Cys Trp Ser 
                965                 970                 975     


Gln Arg Gly Glu Asp Gly Met Cys Ala Gly Pro Leu Ala Gly Pro Ala 
            980                 985                 990         


Leu Thr Phe Asp Asp Cys Cys Cys  Arg Gln Gly Arg Gly  Trp Gly Ala 
        995                 1000                 1005             


Gln Cys  Arg Pro Cys Pro Pro  Arg Gly Ala Gly Ser  His Cys Pro 
    1010                 1015                 1020             


Thr Ser  Gln Ser Glu Ser Asn  Ser Phe Trp Asp Thr  Ser Pro Leu 
    1025                 1030                 1035             


Leu Leu  Gly Lys Pro Pro Arg  Asp Glu Asp Ser Ser  Glu Glu Asp 
    1040                 1045                 1050             


Ser Asp  Glu Cys Arg Cys Val  Ser Gly Arg Cys Val  Pro Arg Pro 
    1055                 1060                 1065             


Gly Gly  Ala Val Cys Glu Cys  Pro Gly Gly Phe Gln  Leu Asp Ala 
    1070                 1075                 1080             


Ser Arg  Ala Arg Cys Val Asp  Ile Asp Glu Cys Arg  Glu Leu Asn 
    1085                 1090                 1095             


Gln Arg  Gly Leu Leu Cys Lys  Ser Glu Arg Cys Val  Asn Thr Ser 
    1100                 1105                 1110             


Gly Ser  Phe Arg Cys Val Cys  Lys Ala Gly Phe Ala  Arg Ser Arg 
    1115                 1120                 1125             


Pro His  Gly Ala Cys Val Pro  Gln Arg Arg Arg 
    1130                 1135                 


<210>  2073
<211>  429
<212>  PRT
<213>  Homo sapiens

<400>  2073

Met Ala Ala Gln Gly Tyr Gly Tyr Tyr Arg Thr Val Ile Phe Ser Ala 
1               5                   10                  15      


Met Phe Gly Gly Tyr Ser Leu Tyr Tyr Phe Asn Arg Lys Thr Phe Ser 
            20                  25                  30          


Phe Val Met Pro Ser Leu Val Glu Glu Ile Pro Leu Asp Lys Asp Asp 
        35                  40                  45              


Leu Gly Phe Ile Thr Ser Ser Gln Ser Ala Ala Tyr Ala Ile Ser Lys 
    50                  55                  60                  


Phe Val Ser Gly Val Leu Ser Asp Gln Met Ser Ala Arg Trp Leu Phe 
65                  70                  75                  80  


Ser Ser Gly Leu Leu Leu Val Gly Leu Val Asn Ile Phe Phe Ala Trp 
                85                  90                  95      


Ser Ser Thr Val Pro Val Phe Ala Ala Leu Trp Phe Leu Asn Gly Leu 
            100                 105                 110         


Ala Gln Gly Leu Gly Trp Pro Pro Cys Gly Lys Val Leu Arg Lys Trp 
        115                 120                 125             


Phe Glu Pro Ser Gln Phe Gly Thr Trp Trp Ala Ile Leu Ser Thr Ser 
    130                 135                 140                 


Met Asn Leu Ala Gly Gly Leu Gly Pro Ile Leu Ala Thr Ile Leu Ala 
145                 150                 155                 160 


Gln Ser Tyr Ser Trp Arg Ser Thr Leu Ala Leu Ser Gly Ala Leu Cys 
                165                 170                 175     


Val Val Val Ser Phe Leu Cys Leu Leu Leu Ile His Asn Glu Pro Ala 
            180                 185                 190         


Asp Val Gly Leu Arg Asn Leu Asp Pro Met Pro Ser Glu Gly Lys Lys 
        195                 200                 205             


Gly Ser Leu Lys Glu Glu Ser Thr Leu Gln Glu Leu Leu Leu Ser Pro 
    210                 215                 220                 


Tyr Leu Trp Val Leu Ser Thr Gly Tyr Leu Val Val Phe Gly Val Lys 
225                 230                 235                 240 


Thr Cys Cys Thr Asp Trp Gly Gln Phe Phe Leu Ile Gln Glu Lys Gly 
                245                 250                 255     


Gln Ser Ala Leu Val Gly Ser Ser Tyr Met Ser Ala Leu Glu Val Gly 
            260                 265                 270         


Gly Leu Val Gly Ser Ile Ala Ala Gly Tyr Leu Ser Asp Arg Ala Met 
        275                 280                 285             


Ala Lys Ala Gly Leu Ser Asn Tyr Gly Asn Pro Arg His Gly Leu Leu 
    290                 295                 300                 


Leu Phe Met Met Ala Gly Met Thr Val Ser Met Tyr Leu Phe Arg Val 
305                 310                 315                 320 


Thr Val Thr Ser Asp Ser Pro Lys Leu Trp Ile Leu Val Leu Gly Ala 
                325                 330                 335     


Val Phe Gly Phe Ser Ser Tyr Gly Pro Ile Ala Leu Phe Gly Val Ile 
            340                 345                 350         


Ala Asn Glu Ser Ala Pro Pro Asn Leu Cys Gly Thr Ser His Ala Ile 
        355                 360                 365             


Val Gly Leu Met Ala Asn Val Gly Gly Phe Leu Ala Gly Leu Pro Phe 
    370                 375                 380                 


Ser Thr Ile Ala Lys His Tyr Ser Trp Ser Thr Ala Phe Trp Val Ala 
385                 390                 395                 400 


Glu Val Ile Cys Ala Ala Ser Thr Ala Ala Phe Phe Leu Leu Arg Asn 
                405                 410                 415     


Ile Arg Thr Lys Met Gly Arg Val Ser Lys Lys Ala Glu 
            420                 425                 


<210>  2074
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  2074

Met Ala Ala Gln Gly Tyr Gly Tyr Tyr Arg Thr Val Ile Phe Ser Ala 
1               5                   10                  15      


Met Phe Gly Gly Tyr Ser Leu Tyr Tyr Phe Asn Arg Lys Thr Phe Ser 
            20                  25                  30          


Phe Val Met Pro Ser Leu Val Glu Glu Ile Pro Leu Asp Lys Asp Asp 
        35                  40                  45              


Leu Gly Phe Ile Thr Ser Ser Gln Ser Ala Ala Tyr Ala Ile Ser Lys 
    50                  55                  60                  


Phe Val Ser Gly Val Leu Ser Asp Gln Met Ser Ala Arg Trp Leu Phe 
65                  70                  75                  80  


Ser Ser Gly Leu Leu Leu Val Gly Leu Val Asn Ile Phe Phe Ala Trp 
                85                  90                  95      


Ser Ser Thr Val Pro Val Phe Ala Ala Leu Trp Phe Leu Asn Gly Leu 
            100                 105                 110         


Ala Gln Gly Leu Gly Trp Pro Pro Cys Gly Lys Val Leu Arg Lys Trp 
        115                 120                 125             


Phe Glu Pro Ser Gln Phe Gly Thr Trp Trp Ala Ile Leu Ser Thr Ser 
    130                 135                 140                 


Met Asn Leu Ala Gly Gly Leu Gly Pro Ile Leu Ala Thr Ile Leu Ala 
145                 150                 155                 160 


Gln Ser Tyr Ser Trp Arg Ser Thr Leu Ala Leu Ser Gly Ala Leu Cys 
                165                 170                 175     


Val Val Val Ser Phe Leu Cys Leu Leu Leu Ile His Asn Glu Pro Ala 
            180                 185                 190         


Asp Val Gly Leu Arg Asn Leu Asp Pro Met Pro Ser Glu Gly Lys Lys 
        195                 200                 205             


Gly Ser Leu Lys Glu Glu Ser Thr Leu Gln Glu Leu Leu Leu Ser Pro 
    210                 215                 220                 


Tyr Leu Trp Val Leu Ser Thr Gly Tyr Leu Val Val Phe Gly Val Lys 
225                 230                 235                 240 


Thr Cys Cys Thr Asp Trp Gly Gln Phe Phe Leu Ile Gln Glu Lys Gly 
                245                 250                 255     


Gln Ser Ala Leu Val Gly Ser Ser Tyr Met Ser Ala Leu Glu Val Gly 
            260                 265                 270         


Gly Leu Val Gly Ser Ile Ala Ala Gly Tyr Leu Ser Asp Arg Ala Met 
        275                 280                 285             


Ala Lys Ala Gly Leu Ser Asn Tyr Gly Asn Pro Arg His Gly Leu Leu 
    290                 295                 300                 


Leu Phe Met Met Ala Gly Met Thr Val Ser Met Tyr Leu Phe Arg Val 
305                 310                 315                 320 


Thr Val Thr Ser Asp Ser Pro Lys Asp Val Ala Phe Trp Thr Leu Ala 
                325                 330                 335     


Leu His Pro Leu Ala Glu Leu Thr Gly Phe Thr Glu His Glu Leu Trp 
            340                 345                 350         


Ile Leu Val Leu Gly Ala Val Phe Gly Phe Ser Ser Tyr Gly Pro Ile 
        355                 360                 365             


Ala Leu Phe Gly Val Ile Ala Asn Glu Ser Ala Pro Pro Asn Leu Cys 
    370                 375                 380                 


Gly Thr Ser His Ala Ile Val Gly Leu Met Ala Asn Val Gly Gly Phe 
385                 390                 395                 400 


Leu Ala Gly Leu Pro Phe Ser Thr Ile Ala Lys His Tyr Ser Trp Ser 
                405                 410                 415     


Thr Ala Phe Trp Val Ala Glu Val Ile Cys Ala Ala Ser Thr Ala Ala 
            420                 425                 430         


Phe Phe Leu Leu Arg Asn Ile Arg Thr Lys Met Gly Arg Val Ser Lys 
        435                 440                 445             


Lys Ala Glu 
    450     


<210>  2075
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  2075

Met Ser Ala Arg Trp Leu Phe Ser Ser Gly Leu Leu Leu Val Gly Leu 
1               5                   10                  15      


Val Asn Ile Phe Phe Ala Trp Ser Ser Thr Val Pro Val Phe Ala Ala 
            20                  25                  30          


Leu Trp Phe Leu Asn Gly Leu Ala Gln Gly Leu Gly Trp Pro Pro Cys 
        35                  40                  45              


Gly Lys Val Leu Arg Lys Trp Phe Glu Pro Ser Gln Phe Gly Thr Trp 
    50                  55                  60                  


Trp Ala Ile Leu Ser Thr Ser Met Asn Leu Ala Gly Gly Leu Gly Pro 
65                  70                  75                  80  


Ile Leu Ala Thr Ile Leu Ala Gln Ser Tyr Ser Trp Arg Ser Thr Leu 
                85                  90                  95      


Ala Leu Ser Gly Ala Leu Cys Val Val Val Ser Phe Leu Cys Leu Leu 
            100                 105                 110         


Leu Ile His Asn Glu Pro Ala Asp Val Gly Leu Arg Asn Leu Asp Pro 
        115                 120                 125             


Met Pro Ser Glu Gly Lys Lys Gly Ser Leu Lys Glu Glu Ser Thr Leu 
    130                 135                 140                 


Gln Glu Leu Leu Leu Ser Pro Tyr Leu Trp Val Leu Ser Thr Gly Tyr 
145                 150                 155                 160 


Leu Val Val Phe Gly Val Lys Thr Cys Cys Thr Asp Trp Gly Gln Phe 
                165                 170                 175     


Phe Leu Ile Gln Glu Lys Gly Gln Ser Ala Leu Val Gly Ser Ser Tyr 
            180                 185                 190         


Met Ser Ala Leu Glu Val Gly Gly Leu Val Gly Ser Ile Ala Ala Gly 
        195                 200                 205             


Tyr Leu Ser Asp Arg Ala Met Ala Lys Ala Gly Leu Ser Asn Tyr Gly 
    210                 215                 220                 


Asn Pro Arg His Gly Leu Leu Leu Phe Met Met Ala Gly Met Thr Val 
225                 230                 235                 240 


Ser Met Tyr Leu Phe Arg Val Thr Val Thr Ser Asp Ser Pro Lys Leu 
                245                 250                 255     


Trp Ile Leu Val Leu Gly Ala Val Phe Gly Phe Ser Ser Tyr Gly Pro 
            260                 265                 270         


Ile Ala Leu Phe Gly Val Ile Ala Asn Glu Ser Ala Pro Pro Asn Leu 
        275                 280                 285             


Cys Gly Thr Ser His Ala Ile Val Gly Leu Met Ala Asn Val Gly Gly 
    290                 295                 300                 


Phe Leu Ala Gly Leu Pro Phe Ser Thr Ile Ala Lys His Tyr Ser Trp 
305                 310                 315                 320 


Ser Thr Ala Phe Trp Val Ala Glu Val Ile Cys Ala Ala Ser Thr Ala 
                325                 330                 335     


Ala Phe Phe Leu Leu Arg Asn Ile Arg Thr Lys Met Gly Arg Val Ser 
            340                 345                 350         


Lys Lys Ala Glu 
        355     


<210>  2076
<211>  429
<212>  PRT
<213>  Homo sapiens

<400>  2076

Met Ala Ala Gln Gly Tyr Gly Tyr Tyr Arg Thr Val Ile Phe Ser Ala 
1               5                   10                  15      


Met Phe Gly Gly Tyr Ser Leu Tyr Tyr Phe Asn Arg Lys Thr Phe Ser 
            20                  25                  30          


Phe Val Met Pro Ser Leu Val Glu Glu Ile Pro Leu Asp Lys Asp Asp 
        35                  40                  45              


Leu Gly Phe Ile Thr Ser Ser Gln Ser Ala Ala Tyr Ala Ile Ser Lys 
    50                  55                  60                  


Phe Val Ser Gly Val Leu Ser Asp Gln Met Ser Ala Arg Trp Leu Phe 
65                  70                  75                  80  


Ser Ser Gly Leu Leu Leu Val Gly Leu Val Asn Ile Phe Phe Ala Trp 
                85                  90                  95      


Ser Ser Thr Val Pro Val Phe Ala Ala Leu Trp Phe Leu Asn Gly Leu 
            100                 105                 110         


Ala Gln Gly Leu Gly Trp Pro Pro Cys Gly Lys Val Leu Arg Lys Trp 
        115                 120                 125             


Phe Glu Pro Ser Gln Phe Gly Thr Trp Trp Ala Ile Leu Ser Thr Ser 
    130                 135                 140                 


Met Asn Leu Ala Gly Gly Leu Gly Pro Ile Leu Ala Thr Ile Leu Ala 
145                 150                 155                 160 


Gln Ser Tyr Ser Trp Arg Ser Thr Leu Ala Leu Ser Gly Ala Leu Cys 
                165                 170                 175     


Val Val Val Ser Phe Leu Cys Leu Leu Leu Ile His Asn Glu Pro Ala 
            180                 185                 190         


Asp Val Gly Leu Arg Asn Leu Asp Pro Met Pro Ser Glu Gly Lys Lys 
        195                 200                 205             


Gly Ser Leu Lys Glu Glu Ser Thr Leu Gln Glu Leu Leu Leu Ser Pro 
    210                 215                 220                 


Tyr Leu Trp Val Leu Ser Thr Gly Tyr Leu Val Val Phe Gly Val Lys 
225                 230                 235                 240 


Thr Cys Cys Thr Asp Trp Gly Gln Phe Phe Leu Ile Gln Glu Lys Gly 
                245                 250                 255     


Gln Ser Ala Leu Val Gly Ser Ser Tyr Met Ser Ala Leu Glu Val Gly 
            260                 265                 270         


Gly Leu Val Gly Ser Ile Ala Ala Gly Tyr Leu Ser Asp Arg Ala Met 
        275                 280                 285             


Ala Lys Ala Gly Leu Ser Asn Tyr Gly Asn Pro Arg His Gly Leu Leu 
    290                 295                 300                 


Leu Phe Met Met Ala Gly Met Thr Val Ser Met Tyr Leu Phe Arg Val 
305                 310                 315                 320 


Thr Val Thr Ser Asp Ser Pro Lys Leu Trp Ile Leu Val Leu Gly Ala 
                325                 330                 335     


Val Phe Gly Phe Ser Ser Tyr Gly Pro Ile Ala Leu Phe Gly Val Ile 
            340                 345                 350         


Ala Asn Glu Ser Ala Pro Pro Asn Leu Cys Gly Thr Ser His Ala Ile 
        355                 360                 365             


Val Gly Leu Met Ala Asn Val Gly Gly Phe Leu Ala Gly Leu Pro Phe 
    370                 375                 380                 


Ser Thr Ile Ala Lys His Tyr Ser Trp Ser Thr Ala Phe Trp Val Ala 
385                 390                 395                 400 


Glu Val Ile Cys Ala Ala Ser Thr Ala Ala Phe Phe Leu Leu Arg Asn 
                405                 410                 415     


Ile Arg Thr Lys Met Gly Arg Val Ser Lys Lys Ala Glu 
            420                 425                 


<210>  2077
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  2077

Met Ala Pro Thr Gly Leu Leu Val Ala Gly Ala Ser Phe Leu Ala Phe 
1               5                   10                  15      


Arg Gly Leu His Trp Gly Leu Arg Arg Leu Pro Thr Pro Glu Ser Ala 
            20                  25                  30          


Ala Arg Asp Arg Trp Gln Trp Trp Asn Leu Cys Val Ser Leu Ala His 
        35                  40                  45              


Ser Leu Leu Ser Gly Thr Gly Ala Leu Leu Gly Leu Ser Leu Tyr Pro 
    50                  55                  60                  


Gln Met Ala Ala Asp Pro Ile His Gly His Pro Arg Trp Ala Leu Val 
65                  70                  75                  80  


Leu Val Ala Val Ser Val Gly Tyr Phe Leu Ala Asp Gly Ala Asp Leu 
                85                  90                  95      


Leu Trp Asn Gln Thr Leu Gly Lys Thr Trp Asp Leu Leu Cys His His 
            100                 105                 110         


Leu Val Val Val Ser Cys Leu Ser Thr Ala Val Leu Ser Gly His Tyr 
        115                 120                 125             


Val Gly Phe Ser Met Val Ser Leu Leu Leu Glu Leu Asn Ser Ala Cys 
    130                 135                 140                 


Leu His Leu Arg Lys Leu Leu Leu Leu Ser Arg Gln Ala Pro Ser Leu 
145                 150                 155                 160 


Ala Phe Ser Val Thr Ser Trp Ala Ser Leu Ala Thr Leu Ala Leu Phe 
                165                 170                 175     


Arg Leu Val Pro Leu Gly Trp Met Ser Leu Trp Leu Phe Arg Gln His 
            180                 185                 190         


His Gln Val Pro Leu Ala Leu Val Thr Leu Gly Gly Ile Gly Leu Val 
        195                 200                 205             


Thr Val Gly Ile Met Ser Ile Ile Leu Gly Ile Arg Ile Leu Val Asn 
    210                 215                 220                 


Asp Val Leu Gln Ser Arg Pro His Pro Pro Ser Pro Gly His Glu Lys 
225                 230                 235                 240 


Thr Arg Gly Thr Arg Thr Arg Arg Asp Asn Gly Pro Val Thr Ser Asn 
                245                 250                 255     


Ser Ser Thr Leu Ser Leu Lys Asp 
            260                 


<210>  2078
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  2078

Met Lys Gly Leu Tyr Gln Ala Ala Gly Arg Ile Leu Val Thr Leu Gly 
1               5                   10                  15      


Ile Leu Ser Val Cys Ser Gly Val Ile Ala Phe Phe Pro Val Phe Ser 
            20                  25                  30          


Tyr Lys Pro Trp Phe Thr Gly Trp Ser Val Arg Ile Ala Cys Pro Ile 
        35                  40                  45              


Trp Asn Gly Ala Leu Ala Ile Thr Thr Gly Val Leu Leu Leu Leu Ala 
    50                  55                  60                  


Tyr Arg Glu Trp Thr Gln Arg Tyr Leu Gly Glu Ala Thr Phe Thr Phe 
65                  70                  75                  80  


Val Ile Leu Ser Ile Met Gly Cys Pro Leu His Phe Ala Ile Ala Leu 
                85                  90                  95      


Glu Ser Ala Leu Leu Gly Pro Tyr Cys Phe Tyr Ser Phe Ser Gly Ile 
            100                 105                 110         


Ala Gly Thr Asn Tyr Leu Gly Tyr Ala Val Thr Phe Pro Tyr Pro Tyr 
        115                 120                 125             


Ala Lys Phe Pro Leu Ala Cys Val Asp Pro Pro His Tyr Glu Glu Tyr 
    130                 135                 140                 


His Leu Thr Leu Gln Ala Leu Asp Leu Cys Leu Ser Phe Thr Leu Leu 
145                 150                 155                 160 


Cys Thr Ser Leu Thr Val Phe Ile Lys Leu Ser Ala Arg Leu Ile Gln 
                165                 170                 175     


Asn Gly His Ile Asn Met Gln Leu Pro Ala Gly Asn Pro Asn Pro Phe 
            180                 185                 190         


Ser Pro 
        


<210>  2079
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  2079

Met Glu Ser Arg Lys Asp Ile Thr Asn Gln Glu Glu Ile Trp Lys Met 
1               5                   10                  15      


Lys Pro Arg Arg Asn Leu Glu Asp Asn Asp Tyr Leu His Glu Asp Thr 
            20                  25                  30          


Gly Glu Thr Ser Met Leu Lys Arg Pro Val Leu Leu His Leu Gln Gln 
        35                  40                  45              


Thr Ala His Ala Asp Glu Phe Asp Cys Pro Ser Glu Leu Gln His Ala 
    50                  55                  60                  


Gln Glu Leu Phe Pro Gln Trp His Leu Pro Ile Lys Ile Ala Ala Val 
65                  70                  75                  80  


Met Ala Ser Leu Thr Phe Leu Tyr Thr Leu Leu Arg Glu Val Ile His 
                85                  90                  95      


Pro Leu Ala Thr Ser His Gln Gln Tyr Phe Tyr Lys Ile Pro Ile Leu 
            100                 105                 110         


Val Ile Asn Lys Val Leu Pro Met Val Ser Ile Thr Leu Leu Ala Leu 
        115                 120                 125             


Val Tyr Leu Pro Gly Val Ile Ala Ala Ile Val Gln Val His Asn Gly 
    130                 135                 140                 


Thr Lys Tyr Lys Lys Phe Pro His Trp Leu Asp Lys Trp Met Leu Thr 
145                 150                 155                 160 


Arg Lys Gln Phe Gly Leu Leu Ser Leu Phe Phe Ala Val Leu His Ala 
                165                 170                 175     


Ile Tyr Thr Leu Ser Tyr Ala Met Arg Arg Ser Tyr Arg Tyr Lys Leu 
            180                 185                 190         


Leu Asn Trp Ala Tyr Gln Gln Val Gln Gln Asn Lys Glu Asp Ala Trp 
        195                 200                 205             


Ile Glu His Asp Val Trp Arg Met Glu Ile Tyr Val Ser Leu Gly Ile 
    210                 215                 220                 


Val Gly Leu Ala Ile Leu Ala Leu Leu Ala Val Thr Ser Ile Pro Ser 
225                 230                 235                 240 


Val Ser Asp Ser Leu Thr Trp Arg Glu Phe His Tyr Ile Gln Ala Ile 
                245                 250                 255     


Leu Thr Gly Ser Leu Val Ala Leu Cys Asn Phe Gln Ala Thr Lys Leu 
            260                 265                 270         


Ala Lys Thr Gln Leu Val Gly Thr Pro Asn Phe Trp Gln Glu Gln Gln 
        275                 280                 285             


Cys Gly Ile His Phe Pro Pro Pro Ser Lys Thr Arg Ser Tyr Ile Tyr 
    290                 295                 300                 


Phe Ile Leu Ser Ala Ala Ser Pro Ser Lys Gly Asn Val Ser Ser His 
305                 310                 315                 320 


Met Phe Gln Leu His Leu Glu Asn Leu Asn Lys Lys Asp Lys Leu Leu 
                325                 330                 335     


Leu Ile Ile Phe Gln Ile 
            340         


<210>  2080
<211>  5335
<212>  PRT
<213>  Homo sapiens

<400>  2080

Met Leu Val Ile Trp Ile Leu Thr Leu Ala Leu Arg Leu Cys Ala Ser 
1               5                   10                  15      


Val Thr Thr Val Thr Pro Gly Ser Thr Val Asn Thr Ser Ile Gly Gly 
            20                  25                  30          


Asn Thr Thr Ser Ala Ser Thr Pro Ser Ser Ser Asp Pro Phe Thr Thr 
        35                  40                  45              


Phe Ser Asp Tyr Gly Val Ser Val Thr Phe Ile Thr Gly Ser Thr Ala 
    50                  55                  60                  


Thr Lys His Phe Leu Asp Ser Ser Thr Asn Ser Gly His Ser Glu Glu 
65                  70                  75                  80  


Ser Thr Val Ser His Ser Gly Pro Gly Ala Thr Gly Thr Thr Leu Phe 
                85                  90                  95      


Pro Ser His Ser Ala Thr Ser Val Phe Val Gly Glu Pro Lys Thr Ser 
            100                 105                 110         


Pro Ile Thr Ser Ala Ser Met Glu Thr Thr Ala Leu Pro Gly Ser Thr 
        115                 120                 125             


Thr Thr Ala Gly Leu Ser Glu Lys Ser Thr Thr Phe Tyr Ser Ser Pro 
    130                 135                 140                 


Arg Ser Pro Asp Arg Thr Leu Ser Pro Ala Arg Thr Thr Ser Ser Gly 
145                 150                 155                 160 


Val Ser Glu Lys Ser Thr Thr Ser His Ser Arg Pro Gly Pro Thr His 
                165                 170                 175     


Thr Ile Ala Phe Pro Asp Ser Thr Thr Met Pro Gly Val Ser Gln Glu 
            180                 185                 190         


Ser Thr Ala Ser His Ser Ile Pro Gly Ser Thr Asp Thr Thr Leu Ser 
        195                 200                 205             


Pro Gly Thr Thr Thr Pro Ser Ser Leu Gly Pro Glu Ser Thr Thr Phe 
    210                 215                 220                 


His Ser Ser Pro Gly Tyr Thr Lys Thr Thr Arg Leu Pro Asp Asn Thr 
225                 230                 235                 240 


Thr Thr Ser Gly Leu Leu Glu Ala Ser Thr Pro Val His Ser Ser Thr 
                245                 250                 255     


Gly Ser Pro His Thr Thr Leu Ser Pro Ser Ser Ser Thr Thr His Glu 
            260                 265                 270         


Gly Glu Pro Thr Thr Phe Gln Ser Trp Pro Ser Ser Lys Asp Thr Ser 
        275                 280                 285             


Pro Ala Pro Ser Gly Thr Thr Ser Ala Phe Val Lys Leu Ser Thr Thr 
    290                 295                 300                 


Tyr His Ser Ser Pro Ser Ser Thr Pro Thr Thr His Phe Ser Ala Ser 
305                 310                 315                 320 


Ser Thr Thr Leu Gly His Ser Glu Glu Ser Thr Pro Val His Ser Ser 
                325                 330                 335     


Pro Val Ala Thr Ala Thr Thr Pro Pro Pro Ala Arg Ser Ala Thr Ser 
            340                 345                 350         


Gly His Val Glu Glu Ser Thr Ala Tyr His Arg Ser Pro Gly Ser Thr 
        355                 360                 365             


Gln Thr Met His Phe Pro Glu Ser Ser Thr Thr Ser Gly His Ser Glu 
    370                 375                 380                 


Glu Ser Ala Thr Phe His Gly Ser Thr Thr His Thr Lys Ser Ser Thr 
385                 390                 395                 400 


Pro Ser Thr Thr Ala Ala Leu Ala His Thr Ser Tyr His Ser Ser Leu 
                405                 410                 415     


Gly Ser Thr Glu Thr Thr His Phe Arg Asp Ser Ser Thr Ile Ser Gly 
            420                 425                 430         


Arg Ser Glu Glu Ser Lys Ala Ser His Ser Ser Pro Asp Ala Met Ala 
        435                 440                 445             


Thr Thr Val Leu Pro Ala Gly Ser Thr Pro Ser Val Leu Val Gly Asp 
    450                 455                 460                 


Ser Thr Pro Ser Pro Ile Ser Ser Gly Ser Met Glu Thr Thr Ala Leu 
465                 470                 475                 480 


Pro Gly Ser Thr Thr Lys Pro Gly Leu Ser Glu Lys Ser Thr Thr Phe 
                485                 490                 495     


Tyr Ser Ser Pro Arg Ser Pro Asp Thr Thr His Leu Pro Ala Ser Met 
            500                 505                 510         


Thr Ser Ser Gly Val Ser Glu Glu Ser Thr Thr Ser His Ser Arg Pro 
        515                 520                 525             


Gly Ser Thr His Thr Thr Ala Phe Pro Gly Ser Thr Thr Met Pro Gly 
    530                 535                 540                 


Leu Ser Gln Glu Ser Thr Ala Ser His Ser Ser Pro Gly Pro Thr Asp 
545                 550                 555                 560 


Thr Thr Leu Ser Pro Gly Ser Thr Thr Ala Ser Ser Leu Gly Pro Glu 
                565                 570                 575     


Tyr Thr Thr Phe His Ser Arg Pro Gly Ser Thr Glu Thr Thr Leu Leu 
            580                 585                 590         


Pro Asp Asn Thr Thr Ala Ser Gly Leu Leu Glu Ala Ser Met Pro Val 
        595                 600                 605             


His Ser Ser Thr Arg Ser Pro His Thr Thr Leu Ser Pro Ala Gly Ser 
    610                 615                 620                 


Thr Thr Arg Gln Gly Glu Ser Thr Thr Phe His Ser Trp Pro Ser Ser 
625                 630                 635                 640 


Lys Asp Thr Arg Pro Ala Pro Pro Thr Thr Thr Ser Ala Phe Val Glu 
                645                 650                 655     


Pro Ser Thr Thr Ser His Gly Ser Pro Ser Ser Ile Pro Thr Thr His 
            660                 665                 670         


Ile Ser Ala Arg Ser Thr Thr Ser Gly Leu Val Glu Glu Ser Thr Thr 
        675                 680                 685             


Tyr His Ser Ser Pro Gly Ser Thr Gln Thr Met His Phe Pro Glu Ser 
    690                 695                 700                 


Asp Thr Thr Ser Gly Arg Gly Glu Glu Ser Thr Thr Ser His Ser Ser 
705                 710                 715                 720 


Thr Thr His Thr Ile Ser Ser Ala Pro Ser Thr Thr Ser Ala Leu Val 
                725                 730                 735     


Glu Glu Pro Thr Ser Tyr His Ser Ser Pro Gly Ser Thr Ala Thr Thr 
            740                 745                 750         


His Phe Pro Asp Ser Ser Thr Thr Ser Gly Arg Ser Glu Glu Ser Thr 
        755                 760                 765             


Ala Ser His Ser Ser Gln Asp Ala Thr Gly Thr Ile Val Leu Pro Ala 
    770                 775                 780                 


Arg Ser Thr Thr Ser Val Leu Leu Gly Glu Ser Thr Thr Ser Pro Ile 
785                 790                 795                 800 


Ser Ser Gly Ser Met Glu Thr Thr Ala Leu Pro Gly Ser Thr Thr Thr 
                805                 810                 815     


Pro Gly Leu Ser Glu Arg Ser Thr Thr Phe His Ser Ser Pro Arg Ser 
            820                 825                 830         


Pro Ala Thr Thr Leu Ser Pro Ala Ser Thr Thr Ser Ser Gly Val Ser 
        835                 840                 845             


Glu Glu Ser Thr Thr Ser Arg Ser Arg Pro Gly Ser Thr His Thr Thr 
    850                 855                 860                 


Ala Phe Pro Asp Ser Thr Thr Thr Pro Gly Leu Ser Arg His Ser Thr 
865                 870                 875                 880 


Thr Ser His Ser Ser Pro Gly Ser Thr Asp Thr Thr Leu Leu Pro Ala 
                885                 890                 895     


Ser Thr Thr Thr Ser Gly Pro Ser Gln Glu Ser Thr Thr Ser His Ser 
            900                 905                 910         


Ser Ser Gly Ser Thr Asp Thr Ala Leu Ser Pro Gly Ser Thr Thr Ala 
        915                 920                 925             


Leu Ser Phe Gly Gln Glu Ser Thr Thr Phe His Ser Asn Pro Gly Ser 
    930                 935                 940                 


Thr His Thr Thr Leu Phe Pro Asp Ser Thr Thr Ser Ser Gly Ile Val 
945                 950                 955                 960 


Glu Ala Ser Thr Arg Val His Ser Ser Thr Gly Ser Pro Arg Thr Thr 
                965                 970                 975     


Leu Ser Pro Ala Ser Ser Thr Ser Pro Gly Leu Gln Gly Glu Ser Thr 
            980                 985                 990         


Ala Phe Gln Thr His Pro Ala Ser  Thr His Thr Thr Pro  Ser Pro Pro 
        995                 1000                 1005             


Ser Thr  Ala Thr Ala Pro Val  Glu Glu Ser Thr Thr  Tyr His Arg 
    1010                 1015                 1020             


Ser Pro  Gly Ser Thr Pro Thr  Thr His Phe Pro Ala  Ser Ser Thr 
    1025                 1030                 1035             


Thr Ser  Gly His Ser Glu Lys  Ser Thr Ile Phe His  Ser Ser Pro 
    1040                 1045                 1050             


Asp Ala  Ser Gly Thr Thr Pro  Ser Ser Ala His Ser  Thr Thr Ser 
    1055                 1060                 1065             


Gly Arg  Gly Glu Ser Thr Thr  Ser Arg Ile Ser Pro  Gly Ser Thr 
    1070                 1075                 1080             


Glu Ile  Thr Thr Leu Pro Gly  Ser Thr Thr Thr Pro  Gly Leu Ser 
    1085                 1090                 1095             


Glu Ala  Ser Thr Thr Phe Tyr  Ser Ser Pro Arg Ser  Pro Thr Thr 
    1100                 1105                 1110             


Thr Leu  Ser Pro Ala Ser Met  Thr Ser Leu Gly Val  Gly Glu Glu 
    1115                 1120                 1125             


Ser Thr  Thr Ser Arg Ser Gln  Pro Gly Ser Thr His  Ser Thr Val 
    1130                 1135                 1140             


Ser Pro  Ala Ser Thr Thr Thr  Pro Gly Leu Ser Glu  Glu Ser Thr 
    1145                 1150                 1155             


Thr Val  Tyr Ser Ser Ser Arg  Gly Ser Thr Glu Thr  Thr Val Phe 
    1160                 1165                 1170             


Pro His  Ser Thr Thr Thr Ser  Val His Gly Glu Glu  Pro Thr Thr 
    1175                 1180                 1185             


Phe His  Ser Arg Pro Ala Ser  Thr His Thr Thr Leu  Phe Thr Glu 
    1190                 1195                 1200             


Asp Ser  Thr Thr Ser Gly Leu  Thr Glu Glu Ser Thr  Ala Phe Pro 
    1205                 1210                 1215             


Gly Ser  Pro Ala Ser Thr Gln  Thr Gly Leu Pro Ala  Thr Leu Thr 
    1220                 1225                 1230             


Thr Ala  Asp Leu Gly Glu Glu  Ser Thr Thr Phe Pro  Ser Ser Ser 
    1235                 1240                 1245             


Gly Ser  Thr Gly Thr Lys Leu  Ser Pro Ala Arg Ser  Thr Thr Ser 
    1250                 1255                 1260             


Gly Leu  Val Gly Glu Ser Thr  Pro Ser Arg Leu Ser  Pro Ser Ser 
    1265                 1270                 1275             


Thr Glu  Thr Thr Thr Leu Pro  Gly Ser Pro Thr Thr  Pro Ser Leu 
    1280                 1285                 1290             


Ser Glu  Lys Ser Thr Thr Phe  Tyr Thr Ser Pro Arg  Ser Pro Asp 
    1295                 1300                 1305             


Ala Thr  Leu Ser Pro Ala Thr  Thr Thr Ser Ser Gly  Val Ser Glu 
    1310                 1315                 1320             


Glu Ser  Ser Thr Ser His Ser  Gln Pro Gly Ser Thr  His Thr Thr 
    1325                 1330                 1335             


Ala Phe  Pro Asp Ser Thr Thr  Thr Ser Asp Leu Ser  Gln Glu Pro 
    1340                 1345                 1350             


Thr Thr  Ser His Ser Ser Gln  Gly Ser Thr Glu Ala  Thr Leu Ser 
    1355                 1360                 1365             


Pro Gly  Ser Thr Thr Ala Ser  Ser Leu Gly Gln Gln  Ser Thr Thr 
    1370                 1375                 1380             


Phe His  Ser Ser Pro Gly Asp  Thr Glu Thr Thr Leu  Leu Pro Asp 
    1385                 1390                 1395             


Asp Thr  Ile Thr Ser Gly Leu  Val Glu Ala Ser Thr  Pro Thr His 
    1400                 1405                 1410             


Ser Ser  Thr Gly Ser Leu His  Thr Thr Leu Thr Pro  Ala Ser Ser 
    1415                 1420                 1425             


Thr Ser  Ala Gly Leu Gln Glu  Glu Ser Thr Thr Phe  Gln Ser Trp 
    1430                 1435                 1440             


Pro Ser  Ser Ser Asp Thr Thr  Pro Ser Pro Pro Gly  Thr Thr Ala 
    1445                 1450                 1455             


Ala Pro  Val Glu Val Ser Thr  Thr Tyr His Ser Arg  Pro Ser Ser 
    1460                 1465                 1470             


Thr Pro  Thr Thr His Phe Ser  Ala Ser Ser Thr Thr  Leu Gly Arg 
    1475                 1480                 1485             


Ser Glu  Glu Ser Thr Thr Val  His Ser Ser Pro Gly  Ala Thr Gly 
    1490                 1495                 1500             


Thr Ala  Leu Phe Pro Thr Arg  Ser Ala Thr Ser Val  Leu Val Gly 
    1505                 1510                 1515             


Glu Pro  Thr Thr Ser Pro Ile  Ser Ser Gly Ser Thr  Glu Thr Thr 
    1520                 1525                 1530             


Ala Leu  Pro Gly Ser Thr Thr  Thr Ala Gly Leu Ser  Glu Lys Ser 
    1535                 1540                 1545             


Thr Thr  Phe Tyr Ser Ser Pro  Arg Ser Pro Asp Thr  Thr Leu Ser 
    1550                 1555                 1560             


Pro Ala  Ser Thr Thr Ser Ser  Gly Val Ser Glu Glu  Ser Thr Thr 
    1565                 1570                 1575             


Ser His  Ser Arg Pro Gly Ser  Thr His Thr Thr Ala  Phe Pro Gly 
    1580                 1585                 1590             


Ser Thr  Thr Met Pro Gly Val  Ser Gln Glu Ser Thr  Ala Ser His 
    1595                 1600                 1605             


Ser Ser  Pro Gly Ser Thr Asp  Thr Thr Leu Ser Pro  Gly Ser Thr 
    1610                 1615                 1620             


Thr Ala  Ser Ser Leu Gly Pro  Glu Ser Thr Thr Phe  His Ser Ser 
    1625                 1630                 1635             


Pro Gly  Ser Thr Glu Thr Thr  Leu Leu Pro Asp Asn  Thr Thr Ala 
    1640                 1645                 1650             


Ser Gly  Leu Leu Glu Ala Ser  Thr Pro Val His Ser  Ser Thr Gly 
    1655                 1660                 1665             


Ser Pro  His Thr Thr Leu Ser  Pro Ala Gly Ser Thr  Thr Arg Gln 
    1670                 1675                 1680             


Gly Glu  Ser Thr Thr Phe Gln  Ser Trp Pro Ser Ser  Lys Asp Thr 
    1685                 1690                 1695             


Met Pro  Ala Pro Pro Thr Thr  Thr Ser Ala Phe Val  Glu Leu Ser 
    1700                 1705                 1710             


Thr Thr  Ser His Gly Ser Pro  Ser Ser Thr Pro Thr  Thr His Phe 
    1715                 1720                 1725             


Ser Ala  Ser Ser Thr Thr Leu  Gly Arg Ser Glu Glu  Ser Thr Thr 
    1730                 1735                 1740             


Val His  Ser Ser Pro Val Ala  Thr Ala Thr Thr Pro  Ser Pro Ala 
    1745                 1750                 1755             


Arg Ser  Thr Thr Ser Gly Leu  Val Glu Glu Ser Thr  Ala Tyr His 
    1760                 1765                 1770             


Ser Ser  Pro Gly Ser Thr Gln  Thr Met His Phe Pro  Glu Ser Ser 
    1775                 1780                 1785             


Thr Ala  Ser Gly Arg Ser Glu  Glu Ser Arg Thr Ser  His Ser Ser 
    1790                 1795                 1800             


Thr Thr  His Thr Ile Ser Ser  Pro Pro Ser Thr Thr  Ser Ala Leu 
    1805                 1810                 1815             


Val Glu  Glu Pro Thr Ser Tyr  His Ser Ser Pro Gly  Ser Thr Ala 
    1820                 1825                 1830             


Thr Thr  His Phe Pro Asp Ser  Ser Thr Thr Ser Gly  Arg Ser Glu 
    1835                 1840                 1845             


Glu Ser  Thr Ala Ser His Ser  Ser Gln Asp Ala Thr  Gly Thr Ile 
    1850                 1855                 1860             


Val Leu  Pro Ala Arg Ser Thr  Thr Ser Val Leu Leu  Gly Glu Ser 
    1865                 1870                 1875             


Thr Thr  Ser Pro Ile Ser Ser  Gly Ser Met Glu Thr  Thr Ala Leu 
    1880                 1885                 1890             


Pro Gly  Ser Thr Thr Thr Pro  Gly Leu Ser Glu Lys  Ser Thr Thr 
    1895                 1900                 1905             


Phe His  Ser Ser Pro Arg Ser  Pro Ala Thr Thr Leu  Ser Pro Ala 
    1910                 1915                 1920             


Ser Thr  Thr Ser Ser Gly Val  Ser Glu Glu Ser Thr  Thr Ser His 
    1925                 1930                 1935             


Ser Arg  Pro Gly Ser Thr His  Thr Thr Ala Phe Pro  Asp Ser Thr 
    1940                 1945                 1950             


Thr Thr  Pro Gly Leu Ser Arg  His Ser Thr Thr Ser  His Ser Ser 
    1955                 1960                 1965             


Pro Gly  Ser Thr Asp Thr Thr  Leu Leu Pro Ala Ser  Thr Thr Thr 
    1970                 1975                 1980             


Ser Gly  Pro Ser Gln Glu Ser  Thr Thr Ser His Ser  Ser Pro Gly 
    1985                 1990                 1995             


Ser Thr  Asp Thr Ala Leu Ser  Pro Gly Ser Thr Thr  Ala Leu Ser 
    2000                 2005                 2010             


Phe Gly  Gln Glu Ser Thr Thr  Phe His Ser Ser Pro  Gly Ser Thr 
    2015                 2020                 2025             


His Thr  Thr Leu Phe Pro Asp  Ser Thr Thr Ser Ser  Gly Ile Val 
    2030                 2035                 2040             


Glu Ala  Ser Thr Arg Val His  Ser Ser Thr Gly Ser  Pro Arg Thr 
    2045                 2050                 2055             


Thr Leu  Ser Pro Ala Ser Ser  Thr Ser Pro Gly Leu  Gln Gly Glu 
    2060                 2065                 2070             


Ser Thr  Ala Phe Gln Thr His  Pro Ala Ser Thr His  Thr Thr Pro 
    2075                 2080                 2085             


Ser Pro  Pro Ser Thr Ala Thr  Ala Pro Val Glu Glu  Ser Thr Thr 
    2090                 2095                 2100             


Tyr His  Arg Ser Pro Gly Ser  Thr Pro Thr Thr His  Phe Pro Ala 
    2105                 2110                 2115             


Ser Ser  Thr Thr Ser Gly His  Ser Glu Lys Ser Thr  Ile Phe His 
    2120                 2125                 2130             


Ser Ser  Pro Asp Ala Ser Gly  Thr Thr Pro Ser Ser  Ala His Ser 
    2135                 2140                 2145             


Thr Thr  Ser Gly Arg Gly Glu  Ser Thr Thr Ser Arg  Ile Ser Pro 
    2150                 2155                 2160             


Gly Ser  Thr Glu Ile Thr Thr  Leu Pro Gly Ser Thr  Thr Thr Pro 
    2165                 2170                 2175             


Gly Leu  Ser Glu Ala Ser Thr  Thr Phe Tyr Ser Ser  Pro Arg Ser 
    2180                 2185                 2190             


Pro Thr  Thr Thr Leu Ser Pro  Ala Ser Met Thr Ser  Leu Gly Val 
    2195                 2200                 2205             


Gly Glu  Glu Ser Thr Thr Ser  Arg Ser Gln Pro Gly  Ser Thr His 
    2210                 2215                 2220             


Ser Thr  Val Ser Pro Ala Ser  Thr Thr Thr Pro Gly  Leu Ser Glu 
    2225                 2230                 2235             


Glu Ser  Thr Thr Val Tyr Ser  Ser Ser Pro Gly Ser  Thr Glu Thr 
    2240                 2245                 2250             


Thr Val  Phe Pro Arg Thr Pro  Thr Thr Ser Val Arg  Gly Glu Glu 
    2255                 2260                 2265             


Pro Thr  Thr Phe His Ser Arg  Pro Ala Ser Thr His  Thr Thr Leu 
    2270                 2275                 2280             


Phe Thr  Glu Asp Ser Thr Thr  Ser Gly Leu Thr Glu  Glu Ser Thr 
    2285                 2290                 2295             


Ala Phe  Pro Gly Ser Pro Ala  Ser Thr Gln Thr Gly  Leu Pro Ala 
    2300                 2305                 2310             


Thr Leu  Thr Thr Ala Asp Leu  Gly Glu Glu Ser Thr  Thr Phe Pro 
    2315                 2320                 2325             


Ser Ser  Ser Gly Ser Thr Gly  Thr Thr Leu Ser Pro  Ala Arg Ser 
    2330                 2335                 2340             


Thr Thr  Ser Gly Leu Val Gly  Glu Ser Thr Pro Ser  Arg Leu Ser 
    2345                 2350                 2355             


Pro Ser  Ser Thr Glu Thr Thr  Thr Leu Pro Gly Ser  Pro Thr Thr 
    2360                 2365                 2370             


Pro Ser  Leu Ser Glu Lys Ser  Thr Thr Phe Tyr Thr  Ser Pro Arg 
    2375                 2380                 2385             


Ser Pro  Asp Ala Thr Leu Ser  Pro Ala Thr Thr Thr  Ser Ser Gly 
    2390                 2395                 2400             


Val Ser  Glu Glu Ser Ser Thr  Ser His Ser Gln Pro  Gly Ser Thr 
    2405                 2410                 2415             


His Thr  Thr Ala Phe Pro Asp  Ser Thr Thr Thr Pro  Gly Leu Ser 
    2420                 2425                 2430             


Arg His  Ser Thr Thr Ser His  Ser Ser Pro Gly Ser  Thr Asp Thr 
    2435                 2440                 2445             


Thr Leu  Leu Pro Ala Ser Thr  Thr Thr Ser Gly Pro  Ser Gln Glu 
    2450                 2455                 2460             


Ser Thr  Thr Ser His Ser Ser  Pro Gly Ser Thr Asp  Thr Ala Leu 
    2465                 2470                 2475             


Ser Pro  Gly Ser Thr Thr Ala  Leu Ser Phe Gly Gln  Glu Ser Thr 
    2480                 2485                 2490             


Thr Phe  His Ser Ser Pro Gly  Ser Thr His Thr Thr  Leu Phe Pro 
    2495                 2500                 2505             


Asp Ser  Thr Thr Ser Ser Gly  Ile Val Glu Ala Ser  Thr Arg Val 
    2510                 2515                 2520             


His Ser  Ser Thr Gly Ser Pro  Arg Thr Thr Leu Ser  Pro Ala Ser 
    2525                 2530                 2535             


Ser Thr  Ser Pro Gly Leu Gln  Gly Glu Ser Thr Thr  Phe Gln Thr 
    2540                 2545                 2550             


His Pro  Ala Ser Thr His Thr  Thr Pro Ser Pro Pro  Ser Thr Ala 
    2555                 2560                 2565             


Thr Ala  Pro Val Glu Glu Ser  Thr Thr Tyr His Arg  Ser Pro Gly 
    2570                 2575                 2580             


Ser Thr  Pro Thr Thr His Phe  Pro Ala Ser Ser Thr  Thr Ser Gly 
    2585                 2590                 2595             


His Ser  Glu Lys Ser Thr Ile  Phe His Ser Ser Pro  Asp Ala Ser 
    2600                 2605                 2610             


Gly Thr  Thr Pro Ser Ser Ala  His Ser Thr Thr Ser  Gly Arg Gly 
    2615                 2620                 2625             


Glu Ser  Thr Thr Ser Arg Ile  Ser Pro Gly Ser Thr  Glu Ile Thr 
    2630                 2635                 2640             


Thr Leu  Pro Gly Ser Thr Thr  Thr Pro Gly Leu Ser  Glu Ala Ser 
    2645                 2650                 2655             


Thr Thr  Phe Tyr Ser Ser Pro  Arg Ser Pro Thr Thr  Thr Leu Ser 
    2660                 2665                 2670             


Pro Ala  Ser Met Thr Ser Leu  Gly Val Gly Glu Glu  Ser Thr Thr 
    2675                 2680                 2685             


Ser Arg  Ser Gln Pro Gly Ser  Thr His Ser Thr Val  Ser Pro Ala 
    2690                 2695                 2700             


Ser Thr  Thr Thr Pro Gly Leu  Ser Glu Glu Ser Thr  Thr Val Tyr 
    2705                 2710                 2715             


Ser Ser  Ser Pro Gly Ser Thr  Glu Thr Thr Val Phe  Pro Arg Ser 
    2720                 2725                 2730             


Thr Thr  Thr Ser Val Arg Gly  Glu Glu Pro Thr Thr  Phe His Ser 
    2735                 2740                 2745             


Arg Pro  Ala Ser Thr His Thr  Thr Leu Phe Thr Glu  Asp Ser Thr 
    2750                 2755                 2760             


Thr Ser  Gly Leu Thr Glu Glu  Ser Thr Ala Phe Pro  Gly Ser Pro 
    2765                 2770                 2775             


Ala Ser  Thr Gln Thr Gly Leu  Pro Ala Thr Leu Thr  Thr Ala Asp 
    2780                 2785                 2790             


Leu Gly  Glu Glu Ser Thr Thr  Phe Pro Ser Ser Ser  Gly Ser Thr 
    2795                 2800                 2805             


Gly Thr  Thr Leu Ser Pro Ala  Arg Ser Thr Thr Ser  Gly Leu Val 
    2810                 2815                 2820             


Gly Glu  Ser Thr Pro Ser Arg  Leu Ser Pro Ser Ser  Thr Glu Thr 
    2825                 2830                 2835             


Thr Thr  Leu Pro Gly Ser Pro  Thr Thr Pro Ser Leu  Ser Glu Lys 
    2840                 2845                 2850             


Ser Thr  Thr Phe Tyr Thr Ser  Pro Arg Ser Pro Asp  Ala Thr Leu 
    2855                 2860                 2865             


Ser Pro  Ala Thr Thr Thr Ser  Ser Gly Val Ser Glu  Glu Ser Ser 
    2870                 2875                 2880             


Thr Ser  His Ser Gln Pro Gly  Ser Thr His Thr Thr  Ala Phe Pro 
    2885                 2890                 2895             


Asp Ser  Thr Thr Thr Ser Gly  Leu Ser Gln Glu Pro  Thr Ala Ser 
    2900                 2905                 2910             


His Ser  Ser Gln Gly Ser Thr  Glu Ala Thr Leu Ser  Pro Gly Ser 
    2915                 2920                 2925             


Thr Thr  Ala Ser Ser Leu Gly  Gln Gln Ser Thr Thr  Phe His Ser 
    2930                 2935                 2940             


Ser Pro  Gly Asp Thr Glu Thr  Thr Leu Leu Pro Asp  Asp Thr Ile 
    2945                 2950                 2955             


Thr Ser  Gly Leu Val Glu Ala  Ser Thr Pro Thr His  Ser Ser Thr 
    2960                 2965                 2970             


Gly Ser  Leu His Thr Thr Leu  Thr Pro Ala Ser Ser  Thr Ser Ala 
    2975                 2980                 2985             


Gly Leu  Gln Glu Glu Ser Thr  Thr Phe Gln Ser Trp  Pro Ser Ser 
    2990                 2995                 3000             


Ser Asp  Thr Thr Pro Ser Pro  Pro Gly Thr Thr Ala  Ala Pro Val 
    3005                 3010                 3015             


Glu Val  Ser Thr Thr Tyr His  Ser Arg Pro Ser Ser  Thr Pro Thr 
    3020                 3025                 3030             


Thr His  Phe Ser Ala Ser Ser  Thr Thr Leu Gly Arg  Ser Glu Glu 
    3035                 3040                 3045             


Ser Thr  Thr Val His Ser Ser  Pro Gly Ala Thr Gly  Thr Ala Leu 
    3050                 3055                 3060             


Phe Pro  Thr Arg Ser Ala Thr  Ser Val Leu Val Gly  Glu Pro Thr 
    3065                 3070                 3075             


Thr Ser  Pro Ile Ser Ser Gly  Ser Thr Glu Thr Thr  Ala Leu Pro 
    3080                 3085                 3090             


Gly Ser  Thr Thr Thr Ala Gly  Leu Ser Glu Lys Ser  Thr Thr Phe 
    3095                 3100                 3105             


Tyr Ser  Ser Pro Arg Ser Pro  Asp Thr Thr Leu Ser  Pro Ala Ser 
    3110                 3115                 3120             


Thr Thr  Ser Ser Gly Val Ser  Glu Glu Ser Thr Thr  Ser His Ser 
    3125                 3130                 3135             


Arg Pro  Gly Ser Thr His Thr  Thr Ala Phe Pro Gly  Ser Thr Thr 
    3140                 3145                 3150             


Met Pro  Gly Val Ser Gln Glu  Ser Thr Ala Ser His  Ser Ser Pro 
    3155                 3160                 3165             


Gly Ser  Thr Asp Thr Thr Leu  Ser Pro Gly Ser Thr  Thr Ala Ser 
    3170                 3175                 3180             


Ser Leu  Gly Pro Glu Ser Thr  Thr Phe His Ser Gly  Pro Gly Ser 
    3185                 3190                 3195             


Thr Glu  Thr Thr Leu Leu Pro  Asp Asn Thr Thr Ala  Ser Gly Leu 
    3200                 3205                 3210             


Leu Glu  Ala Ser Thr Pro Val  His Ser Ser Thr Gly  Ser Pro His 
    3215                 3220                 3225             


Thr Thr  Leu Ser Pro Ala Gly  Ser Thr Thr Arg Gln  Gly Glu Ser 
    3230                 3235                 3240             


Thr Thr  Phe Gln Ser Trp Pro  Asn Ser Lys Asp Thr  Thr Pro Ala 
    3245                 3250                 3255             


Pro Pro  Thr Thr Thr Ser Ala  Phe Val Glu Leu Ser  Thr Thr Ser 
    3260                 3265                 3270             


His Gly  Ser Pro Ser Ser Thr  Pro Thr Thr His Phe  Ser Ala Ser 
    3275                 3280                 3285             


Ser Thr  Thr Leu Gly Arg Ser  Glu Glu Ser Thr Thr  Val His Ser 
    3290                 3295                 3300             


Ser Pro  Val Ala Thr Ala Thr  Thr Pro Ser Pro Ala  Arg Ser Thr 
    3305                 3310                 3315             


Thr Ser  Gly Leu Val Glu Glu  Ser Thr Thr Tyr His  Ser Ser Pro 
    3320                 3325                 3330             


Gly Ser  Thr Gln Thr Met His  Phe Pro Glu Ser Asp  Thr Thr Ser 
    3335                 3340                 3345             


Gly Arg  Gly Glu Glu Ser Thr  Thr Ser His Ser Ser  Thr Thr His 
    3350                 3355                 3360             


Thr Ile  Ser Ser Ala Pro Ser  Thr Thr Ser Ala Leu  Val Glu Glu 
    3365                 3370                 3375             


Pro Thr  Ser Tyr His Ser Ser  Pro Gly Ser Thr Ala  Thr Thr His 
    3380                 3385                 3390             


Phe Pro  Asp Ser Ser Thr Thr  Ser Gly Arg Ser Glu  Glu Ser Thr 
    3395                 3400                 3405             


Ala Ser  His Ser Ser Gln Asp  Ala Thr Gly Thr Ile  Val Leu Pro 
    3410                 3415                 3420             


Ala Arg  Ser Thr Thr Ser Val  Leu Leu Gly Glu Ser  Thr Thr Ser 
    3425                 3430                 3435             


Pro Ile  Ser Ser Gly Ser Met  Glu Thr Thr Ala Leu  Pro Gly Ser 
    3440                 3445                 3450             


Thr Thr  Thr Pro Gly Leu Ser  Glu Lys Ser Thr Thr  Phe His Ser 
    3455                 3460                 3465             


Ser Pro  Arg Ser Pro Ala Thr  Thr Leu Ser Pro Ala  Ser Thr Thr 
    3470                 3475                 3480             


Ser Ser  Gly Val Ser Glu Glu  Ser Thr Thr Ser His  Ser Arg Pro 
    3485                 3490                 3495             


Gly Ser  Thr His Thr Thr Ala  Phe Pro Asp Ser Thr  Thr Thr Pro 
    3500                 3505                 3510             


Gly Leu  Ser Arg His Ser Thr  Thr Ser His Ser Ser  Pro Gly Ser 
    3515                 3520                 3525             


Thr Asp  Thr Thr Leu Leu Pro  Ala Ser Thr Thr Thr  Ser Gly Ser 
    3530                 3535                 3540             


Ser Gln  Glu Ser Thr Thr Ser  His Ser Ser Ser Gly  Ser Thr Asp 
    3545                 3550                 3555             


Thr Ala  Leu Ser Pro Gly Ser  Thr Thr Ala Leu Ser  Phe Gly Gln 
    3560                 3565                 3570             


Glu Ser  Thr Thr Phe His Ser  Ser Pro Gly Ser Thr  His Thr Thr 
    3575                 3580                 3585             


Leu Phe  Pro Asp Ser Thr Thr  Ser Ser Gly Ile Val  Glu Ala Ser 
    3590                 3595                 3600             


Thr Arg  Val His Ser Ser Thr  Gly Ser Pro Arg Thr  Thr Leu Ser 
    3605                 3610                 3615             


Pro Ala  Ser Ser Thr Ser Pro  Gly Leu Gln Gly Glu  Ser Thr Ala 
    3620                 3625                 3630             


Phe Gln  Thr His Pro Ala Ser  Thr His Thr Thr Pro  Ser Pro Pro 
    3635                 3640                 3645             


Ser Thr  Ala Thr Ala Pro Val  Glu Glu Ser Thr Thr  Tyr His Arg 
    3650                 3655                 3660             


Ser Pro  Gly Ser Thr Pro Thr  Thr His Phe Pro Ala  Ser Ser Thr 
    3665                 3670                 3675             


Thr Ser  Gly His Ser Glu Lys  Ser Thr Ile Phe His  Ser Ser Pro 
    3680                 3685                 3690             


Asp Ala  Ser Gly Thr Thr Pro  Ser Ser Ala His Ser  Thr Thr Ser 
    3695                 3700                 3705             


Gly Arg  Gly Glu Ser Thr Thr  Ser Arg Ile Ser Pro  Gly Ser Thr 
    3710                 3715                 3720             


Glu Ile  Thr Thr Leu Pro Gly  Ser Thr Thr Thr Pro  Gly Leu Ser 
    3725                 3730                 3735             


Glu Ala  Ser Thr Thr Phe Tyr  Ser Ser Pro Arg Ser  Pro Thr Thr 
    3740                 3745                 3750             


Thr Leu  Ser Pro Ala Ser Met  Thr Ser Leu Gly Val  Gly Glu Glu 
    3755                 3760                 3765             


Ser Thr  Thr Ser Arg Ser Gln  Pro Gly Ser Thr His  Ser Thr Val 
    3770                 3775                 3780             


Ser Pro  Ala Ser Thr Thr Thr  Pro Gly Leu Ser Glu  Glu Ser Thr 
    3785                 3790                 3795             


Thr Val  Tyr Ser Ser Ser Pro  Gly Ser Thr Glu Thr  Thr Val Phe 
    3800                 3805                 3810             


Pro Arg  Ser Thr Thr Thr Ser  Val Arg Arg Glu Glu  Pro Thr Thr 
    3815                 3820                 3825             


Phe His  Ser Arg Pro Ala Ser  Thr His Thr Thr Leu  Phe Thr Glu 
    3830                 3835                 3840             


Asp Ser  Thr Thr Ser Gly Leu  Thr Glu Glu Ser Thr  Ala Phe Pro 
    3845                 3850                 3855             


Gly Ser  Pro Ala Ser Thr Gln  Thr Gly Leu Pro Ala  Thr Leu Thr 
    3860                 3865                 3870             


Thr Ala  Asp Leu Gly Glu Glu  Ser Thr Thr Phe Pro  Ser Ser Ser 
    3875                 3880                 3885             


Gly Ser  Thr Gly Thr Lys Leu  Ser Pro Ala Arg Ser  Thr Thr Ser 
    3890                 3895                 3900             


Gly Leu  Val Gly Glu Ser Thr  Pro Ser Arg Leu Ser  Pro Ser Ser 
    3905                 3910                 3915             


Thr Glu  Thr Thr Thr Leu Pro  Gly Ser Pro Thr Thr  Pro Ser Leu 
    3920                 3925                 3930             


Ser Glu  Lys Ser Thr Thr Phe  Tyr Thr Ser Pro Arg  Ser Pro Asp 
    3935                 3940                 3945             


Ala Thr  Leu Ser Pro Ala Thr  Thr Thr Ser Ser Gly  Val Ser Glu 
    3950                 3955                 3960             


Glu Ser  Ser Thr Ser His Ser  Gln Pro Gly Ser Thr  His Thr Thr 
    3965                 3970                 3975             


Ala Phe  Pro Asp Ser Thr Thr  Thr Ser Gly Leu Ser  Gln Glu Pro 
    3980                 3985                 3990             


Thr Thr  Ser His Ser Ser Gln  Gly Ser Thr Glu Ala  Thr Leu Ser 
    3995                 4000                 4005             


Pro Gly  Ser Thr Thr Ala Ser  Ser Leu Gly Gln Gln  Ser Thr Thr 
    4010                 4015                 4020             


Phe His  Ser Ser Pro Gly Asp  Thr Glu Thr Thr Leu  Leu Pro Asp 
    4025                 4030                 4035             


Asp Thr  Ile Thr Ser Gly Leu  Val Glu Ala Ser Thr  Pro Thr His 
    4040                 4045                 4050             


Ser Ser  Thr Gly Ser Leu His  Thr Thr Leu Thr Pro  Ala Ser Ser 
    4055                 4060                 4065             


Thr Ser  Thr Gly Leu Gln Glu  Glu Ser Thr Thr Phe  Gln Ser Trp 
    4070                 4075                 4080             


Pro Ser  Ser Ser Asp Thr Thr  Pro Ser Pro Pro Ser  Thr Thr Ala 
    4085                 4090                 4095             


Val Pro  Val Glu Val Ser Thr  Thr Tyr His Ser Arg  Pro Ser Ser 
    4100                 4105                 4110             


Thr Pro  Thr Thr His Phe Ser  Ala Ser Ser Thr Thr  Leu Gly Arg 
    4115                 4120                 4125             


Ser Glu  Glu Ser Thr Thr Val  His Ser Ser Pro Gly  Ala Thr Gly 
    4130                 4135                 4140             


Thr Ala  Leu Phe Pro Thr Arg  Ser Ala Thr Ser Val  Leu Val Gly 
    4145                 4150                 4155             


Glu Pro  Thr Thr Ser Pro Ile  Ser Ser Gly Ser Thr  Glu Thr Thr 
    4160                 4165                 4170             


Ala Leu  Pro Gly Ser Thr Thr  Thr Ala Gly Leu Ser  Glu Lys Ser 
    4175                 4180                 4185             


Thr Thr  Phe Tyr Ser Ser Pro  Arg Ser Pro Asp Thr  Thr Leu Ser 
    4190                 4195                 4200             


Pro Ala  Ser Thr Thr Ser Ser  Gly Val Ser Glu Glu  Ser Thr Thr 
    4205                 4210                 4215             


Ser His  Ser Arg Pro Gly Ser  Met His Thr Thr Ala  Phe Pro Ser 
    4220                 4225                 4230             


Ser Thr  Thr Met Pro Gly Val  Ser Gln Glu Ser Thr  Ala Ser His 
    4235                 4240                 4245             


Ser Ser  Pro Gly Ser Thr Asp  Thr Thr Leu Ser Pro  Gly Ser Thr 
    4250                 4255                 4260             


Thr Ala  Ser Ser Leu Gly Pro  Glu Ser Thr Thr Phe  His Ser Ser 
    4265                 4270                 4275             


Pro Gly  Ser Thr Glu Thr Thr  Leu Leu Pro Asp Asn  Thr Thr Ala 
    4280                 4285                 4290             


Ser Gly  Leu Leu Glu Ala Ser  Thr Pro Val His Ser  Ser Thr Gly 
    4295                 4300                 4305             


Ser Pro  His Thr Thr Leu Ser  Pro Ala Gly Ser Thr  Thr Arg Gln 
    4310                 4315                 4320             


Gly Glu  Ser Thr Thr Phe Gln  Ser Trp Pro Asn Ser  Lys Asp Thr 
    4325                 4330                 4335             


Thr Pro  Ala Pro Pro Thr Thr  Thr Ser Ala Phe Val  Glu Leu Ser 
    4340                 4345                 4350             


Thr Thr  Ser His Gly Ser Pro  Ser Ser Thr Pro Thr  Thr His Phe 
    4355                 4360                 4365             


Ser Ala  Ser Ser Thr Thr Leu  Gly Arg Ser Glu Glu  Ser Thr Thr 
    4370                 4375                 4380             


Val His  Ser Ser Pro Val Ala  Thr Ala Thr Thr Pro  Ser Pro Ala 
    4385                 4390                 4395             


Arg Ser  Thr Thr Ser Gly Leu  Val Glu Glu Ser Thr  Thr Tyr His 
    4400                 4405                 4410             


Ser Ser  Pro Gly Ser Thr Gln  Thr Met His Phe Pro  Glu Ser Asn 
    4415                 4420                 4425             


Thr Thr  Ser Gly Arg Gly Glu  Glu Ser Thr Thr Ser  His Ser Ser 
    4430                 4435                 4440             


Thr Thr  His Thr Ile Ser Ser  Ala Pro Ser Thr Thr  Ser Ala Leu 
    4445                 4450                 4455             


Val Glu  Glu Pro Thr Ser Tyr  His Ser Ser Pro Gly  Ser Thr Ala 
    4460                 4465                 4470             


Thr Thr  His Phe Pro Asp Ser  Ser Thr Thr Ser Gly  Arg Ser Glu 
    4475                 4480                 4485             


Glu Ser  Thr Ala Ser His Ser  Ser Gln Asp Ala Thr  Gly Thr Ile 
    4490                 4495                 4500             


Val Leu  Pro Ala Arg Ser Thr  Thr Ser Val Leu Leu  Gly Glu Ser 
    4505                 4510                 4515             


Thr Thr  Ser Pro Ile Ser Ser  Gly Ser Met Glu Thr  Thr Ala Leu 
    4520                 4525                 4530             


Pro Gly  Ser Thr Thr Thr Pro  Gly Leu Ser Glu Lys  Ser Thr Thr 
    4535                 4540                 4545             


Phe His  Ser Ser Pro Ser Ser  Thr Pro Thr Thr His  Phe Ser Ala 
    4550                 4555                 4560             


Ser Ser  Thr Thr Leu Gly Arg  Ser Glu Glu Ser Thr  Thr Val His 
    4565                 4570                 4575             


Ser Ser  Pro Val Ala Thr Ala  Thr Thr Pro Ser Pro  Ala Arg Ser 
    4580                 4585                 4590             


Thr Thr  Ser Gly Leu Val Glu  Glu Ser Thr Ala Tyr  His Ser Ser 
    4595                 4600                 4605             


Pro Gly  Ser Thr Gln Thr Met  His Phe Pro Glu Ser  Ser Thr Ala 
    4610                 4615                 4620             


Ser Gly  Arg Ser Glu Glu Ser  Arg Thr Ser His Ser  Ser Thr Thr 
    4625                 4630                 4635             


His Thr  Ile Ser Ser Pro Pro  Ser Thr Thr Ser Ala  Leu Val Glu 
    4640                 4645                 4650             


Glu Pro  Thr Ser Tyr His Ser  Ser Pro Gly Ser Ile  Ala Thr Thr 
    4655                 4660                 4665             


His Phe  Pro Glu Ser Ser Thr  Thr Ser Gly Arg Ser  Glu Glu Ser 
    4670                 4675                 4680             


Thr Ala  Ser His Ser Ser Pro  Asp Thr Asn Gly Ile  Thr Pro Leu 
    4685                 4690                 4695             


Pro Ala  His Phe Thr Thr Ser  Gly Arg Ile Ala Glu  Ser Thr Thr 
    4700                 4705                 4710             


Phe Tyr  Ile Ser Pro Gly Ser  Met Glu Thr Thr Leu  Ala Ser Thr 
    4715                 4720                 4725             


Ala Thr  Thr Pro Gly Leu Ser  Ala Lys Ser Thr Ile  Leu Tyr Ser 
    4730                 4735                 4740             


Ser Ser  Arg Ser Pro Asp Gln  Thr Leu Ser Pro Ala  Ser Met Thr 
    4745                 4750                 4755             


Ser Ser  Ser Ile Ser Gly Glu  Pro Thr Ser Leu Tyr  Ser Gln Ala 
    4760                 4765                 4770             


Glu Ser  Thr His Thr Thr Ala  Phe Pro Ala Ser Thr  Thr Thr Ser 
    4775                 4780                 4785             


Gly Leu  Ser Gln Glu Ser Thr  Thr Phe His Ser Lys  Pro Gly Ser 
    4790                 4795                 4800             


Thr Glu  Thr Thr Leu Ser Pro  Gly Ser Ile Thr Thr  Ser Ser Phe 
    4805                 4810                 4815             


Ala Gln  Glu Phe Thr Thr Pro  His Ser Gln Pro Gly  Ser Ala Leu 
    4820                 4825                 4830             


Ser Thr  Val Ser Pro Ala Ser  Thr Thr Val Pro Gly  Leu Ser Glu 
    4835                 4840                 4845             


Glu Ser  Thr Thr Phe Tyr Ser  Ser Pro Gly Ser Thr  Glu Thr Thr 
    4850                 4855                 4860             


Ala Phe  Ser His Ser Asn Thr  Met Ser Ile His Ser  Gln Gln Ser 
    4865                 4870                 4875             


Thr Pro  Phe Pro Asp Ser Pro  Gly Phe Thr His Thr  Val Leu Pro 
    4880                 4885                 4890             


Ala Thr  Leu Thr Thr Thr Asp  Ile Gly Gln Glu Ser  Thr Ala Phe 
    4895                 4900                 4905             


His Ser  Ser Ser Asp Ala Thr  Gly Thr Thr Pro Leu  Pro Ala Arg 
    4910                 4915                 4920             


Ser Thr  Ala Ser Asp Leu Val  Gly Glu Pro Thr Thr  Phe Tyr Ile 
    4925                 4930                 4935             


Ser Pro  Ser Pro Thr Tyr Thr  Thr Leu Phe Pro Ala  Ser Ser Ser 
    4940                 4945                 4950             


Thr Ser  Gly Leu Thr Glu Glu  Ser Thr Thr Phe His  Thr Ser Pro 
    4955                 4960                 4965             


Ser Phe  Thr Ser Thr Ile Val  Ser Thr Glu Ser Leu  Glu Thr Leu 
    4970                 4975                 4980             


Ala Pro  Gly Leu Cys Gln Glu  Gly Gln Ile Trp Asn  Gly Lys Gln 
    4985                 4990                 4995             


Cys Val  Cys Pro Gln Gly Tyr  Val Gly Tyr Gln Cys  Leu Ser Pro 
    5000                 5005                 5010             


Leu Glu  Ser Phe Pro Val Glu  Thr Pro Glu Lys Leu  Asn Ala Thr 
    5015                 5020                 5025             


Leu Gly  Met Thr Val Lys Val  Thr Tyr Arg Asn Phe  Thr Glu Lys 
    5030                 5035                 5040             


Met Asn  Asp Ala Ser Ser Gln  Glu Tyr Gln Asn Phe  Ser Thr Leu 
    5045                 5050                 5055             


Phe Lys  Asn Arg Met Asp Val  Val Leu Lys Gly Asp  Asn Leu Pro 
    5060                 5065                 5070             


Gln Tyr  Arg Gly Val Asn Ile  Arg Arg Leu Leu Asn  Gly Ser Ile 
    5075                 5080                 5085             


Val Val  Lys Asn Asp Val Ile  Leu Glu Ala Asp Tyr  Thr Leu Glu 
    5090                 5095                 5100             


Tyr Glu  Glu Leu Phe Glu Asn  Leu Ala Glu Ile Val  Lys Ala Lys 
    5105                 5110                 5115             


Ile Met  Asn Glu Thr Arg Thr  Thr Leu Leu Asp Pro  Asp Ser Cys 
    5120                 5125                 5130             


Arg Lys  Ala Ile Leu Cys Tyr  Ser Glu Glu Asp Thr  Phe Val Asp 
    5135                 5140                 5145             


Ser Ser  Val Thr Pro Gly Phe  Asp Phe Gln Glu Gln  Cys Thr Gln 
    5150                 5155                 5160             


Lys Ala  Ala Glu Gly Tyr Thr  Gln Phe Tyr Tyr Val  Asp Val Leu 
    5165                 5170                 5175             


Asp Gly  Lys Leu Ala Cys Val  Asn Lys Cys Thr Lys  Gly Thr Lys 
    5180                 5185                 5190             


Ser Gln  Met Asn Cys Asn Leu  Gly Thr Cys Gln Leu  Gln Arg Ser 
    5195                 5200                 5205             


Gly Pro  Arg Cys Leu Cys Pro  Asn Thr Asn Thr His  Trp Tyr Trp 
    5210                 5215                 5220             


Gly Glu  Thr Cys Glu Phe Asn  Ile Ala Lys Ser Leu  Val Tyr Gly 
    5225                 5230                 5235             


Ile Val  Gly Ala Val Met Ala  Val Leu Leu Leu Ala  Leu Ile Ile 
    5240                 5245                 5250             


Leu Ile  Ile Leu Phe Ser Leu  Ser Gln Arg Lys Arg  His Arg Glu 
    5255                 5260                 5265             


Gln Tyr  Asp Val Pro Gln Glu  Trp Arg Lys Glu Gly  Thr Pro Gly 
    5270                 5275                 5280             


Ile Phe  Gln Lys Thr Ala Ile  Trp Glu Asp Gln Asn  Leu Arg Glu 
    5285                 5290                 5295             


Ser Arg  Phe Gly Leu Glu Asn  Ala Tyr Asn Asn Phe  Arg Pro Thr 
    5300                 5305                 5310             


Leu Glu  Thr Val Asp Ser Gly  Thr Glu Leu His Ile  Gln Arg Pro 
    5315                 5320                 5325             


Glu Met  Val Ala Ser Thr Val  
    5330                 5335 


<210>  2081
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  2081

Met Pro Arg Pro Gly Ser Ala Gln Arg Trp Ala Ala Val Ala Gly Arg 
1               5                   10                  15      


Trp Gly Cys Arg Leu Leu Ala Leu Leu Leu Leu Val Pro Gly Pro Gly 
            20                  25                  30          


Gly Ala Ser Glu Ile Thr Phe Glu Leu Pro Asp Asn Ala Lys Gln Cys 
        35                  40                  45              


Phe Tyr Glu Asp Ile Ala Gln Gly Thr Lys Cys Thr Leu Glu Phe Gln 
    50                  55                  60                  


Val Ile Thr Gly Gly His Tyr Asp Val Asp Cys Arg Leu Glu Asp Pro 
65                  70                  75                  80  


Asp Gly Lys Val Leu Tyr Lys Glu Met Lys Lys Gln Tyr Asp Ser Phe 
                85                  90                  95      


Thr Phe Thr Ala Ser Lys Asn Gly Thr Tyr Lys Phe Cys Phe Ser Asn 
            100                 105                 110         


Glu Phe Ser Thr Phe Thr His Lys Thr Val Tyr Phe Asp Phe Gln Val 
        115                 120                 125             


Gly Glu Asp Pro Pro Leu Phe Pro Ser Glu Asn Arg Val Ser Ala Leu 
    130                 135                 140                 


Thr Gln Met Glu Ser Ala Cys Val Ser Ile His Glu Ala Leu Lys Ser 
145                 150                 155                 160 


Val Ile Asp Tyr Gln Thr His Phe Arg Leu Arg Glu Ala Gln Gly Arg 
                165                 170                 175     


Ser Arg Ala Glu Asp Leu Asn Thr Arg Val Ala Tyr 
            180                 185             


<210>  2082
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  2082

Met Met Ser Ser Lys Pro Thr Ser His Ala Glu Val Asn Glu Thr Ile 
1               5                   10                  15      


Pro Asn Pro Tyr Pro Pro Ser Ser Phe Met Ala Pro Gly Phe Gln Gln 
            20                  25                  30          


Pro Leu Gly Ser Ile Asn Leu Glu Asn Gln Ala Gln Gly Ala Gln Arg 
        35                  40                  45              


Ala Gln Pro Tyr Gly Ile Thr Ser Pro Gly Ile Phe Ala Ser Ser Gln 
    50                  55                  60                  


Pro Gly Gln Gly Asn Ile Gln Met Ile Asn Pro Ser Val Gly Thr Ala 
65                  70                  75                  80  


Val Met Asn Phe Lys Glu Glu Ala Lys Ala Leu Gly Phe Ile Ile Ser 
                85                  90                  95      


Gly Ser Leu Ser Val Ser Ala Ser Lys Glu Leu Ser Arg Cys Leu Val 
            100                 105                 110         


Lys Gly Ser Leu Gly Met Asn Ile Val Ser Ser Ile Leu Ala Phe Ile 
        115                 120                 125             


Gly Val Ile Leu Leu Leu Val Asp Met Cys Ile Asn Gly Val Ala Gly 
    130                 135                 140                 


Gln Asp Tyr Trp Ala Val Leu Ser Gly Lys Gly Ile Ser Ala Thr Leu 
145                 150                 155                 160 


Met Ile Phe Ser Leu Leu Glu Phe Phe Val Ala Cys Ala Thr Ala His 
                165                 170                 175     


Phe Ala Asn Gln Ala Asn Thr Thr Thr Asn Met Ser Val Leu Val Ile 
            180                 185                 190         


Pro Asn Met Tyr Glu Ser Asn Pro Val Thr Pro Ala Ser Ser Ser Ala 
        195                 200                 205             


Pro Pro Arg Cys Asn Asn Tyr Ser Ala Asn Ala Pro Lys 
    210                 215                 220     


<210>  2083
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  2083

Met Thr Leu Ala Ser Arg Leu Ser Thr Ala Ala Asn Thr Gly Gln Ile 
1               5                   10                  15      


Asp Asp Pro Gln Glu Gln His Arg Val Ile Ser Ser Asn Leu Ala Leu 
            20                  25                  30          


Ile Gln Val Gln Ala Thr Val Val Gly Leu Leu Ala Ala Val Ala Ala 
        35                  40                  45              


Leu Leu Leu Gly Val Val Ser Arg Glu Glu Val Asp Val Ala Lys Val 
    50                  55                  60                  


Glu Leu Leu Cys Ala Ser Ser Val Leu Thr Ala Phe Leu Ala Ala Phe 
65                  70                  75                  80  


Ala Leu Gly Val Leu Met Val Cys Ile Val Ile Gly Ala Arg Lys Leu 
                85                  90                  95      


Gly Val Asn Pro Asp Asn Ile Ala Thr Pro Ile Ala Ala Ser Leu Gly 
            100                 105                 110         


Asp Leu Ile Thr Leu Ser Ile Leu Ala Leu Val Ser Ser Phe Phe Tyr 
        115                 120                 125             


Arg His Lys Asp Ser Arg Tyr Leu Thr Pro Leu Val Cys Leu Ser Phe 
    130                 135                 140                 


Ala Ala Leu Thr Pro Val Trp Val Leu Ile Ala Lys Gln Ser Pro Pro 
145                 150                 155                 160 


Ile Val Lys Ile Leu Lys Phe Gly Trp Phe Pro Ile Ile Leu Ala Met 
                165                 170                 175     


Val Ile Ser Ser Phe Gly Gly Leu Ile Leu Ser Lys Thr Val Ser Lys 
            180                 185                 190         


Gln Gln Tyr Lys Gly Met Ala Ile Phe Thr Pro Val Ile Cys Gly Val 
        195                 200                 205             


Gly Gly Asn Leu Val Ala Ile Gln Thr Ser Arg Ile Ser Thr Tyr Leu 
    210                 215                 220                 


His Met Trp Ser Ala Pro Gly Val Leu Pro Leu Gln Met Lys Lys Phe 
225                 230                 235                 240 


Trp Pro Asn Pro Cys Ser Thr Phe Cys Thr Ser Glu Ile Asn Ser Met 
                245                 250                 255     


Ser Ala Arg Val Leu Leu Leu Leu Val Val Pro Gly His Leu Ile Phe 
            260                 265                 270         


Phe Tyr Ile Ile Tyr Leu Val Glu Gly Gln Ser Val Ile Asn Ser Gln 
        275                 280                 285             


Thr Phe Val Val Leu Tyr Leu Leu Ala Gly Leu Ile Gln Val Thr Ile 
    290                 295                 300                 


Leu Leu Tyr Leu Ala Glu Val Met Val Arg Leu Thr Trp His Gln Ala 
305                 310                 315                 320 


Leu Asp Pro Asp Asn His Cys Ile Pro Tyr Leu Thr Gly Leu Gly Asp 
                325                 330                 335     


Leu Leu Gly Thr Gly Leu Leu Ala Leu Cys Phe Phe Thr Asp Trp Leu 
            340                 345                 350         


Leu Lys Ser Lys Ala Glu Leu Gly Gly Ile Ser Glu Leu Ala Ser Gly 
        355                 360                 365             


Pro Pro 
    370 


<210>  2084
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  2084

Met Arg Gly Leu Gly Leu Trp Leu Leu Gly Ala Met Met Leu Pro Ala 
1               5                   10                  15      


Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val Val 
            20                  25                  30          


Leu Pro Trp Arg Leu Pro Gly Pro Arg Val Arg Arg Ala Leu Pro Ser 
        35                  40                  45              


His Leu Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala Thr 
    50                  55                  60                  


Gly His Asn Phe Thr Leu His Leu Arg Lys Asn Arg Asp Leu Leu Gly 
65                  70                  75                  80  


Ser Gly Tyr Thr Glu Thr Tyr Thr Ala Ala Asn Gly Ser Glu Val Thr 
                85                  90                  95      


Glu Gln Pro Arg Gly Gln Asp His Cys Phe Tyr Gln Gly His Val Glu 
            100                 105                 110         


Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Thr Cys Ala Gly Leu Arg 
        115                 120                 125             


Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu Asp 
    130                 135                 140                 


Glu Gly Gly Glu Gly Gly Arg His Ala Val Tyr Gln Ala Glu His Leu 
145                 150                 155                 160 


Leu Gln Thr Ala Gly Thr Cys Gly Val Ser Asp Asp Ser Leu Gly Ser 
                165                 170                 175     


Leu Leu Gly Pro Arg Thr Ala Ala Val Phe Arg Pro Arg Pro Gly Asp 
            180                 185                 190         


Ser Leu Pro Ser Arg Glu Thr Arg Tyr Val Glu Leu Tyr Val Val Val 
        195                 200                 205             


Asp Asn Ala Glu Phe Gln Met Leu Gly Ser Glu Ala Ala Val Arg His 
    210                 215                 220                 


Arg Val Leu Glu Val Val Asn His Val Asp Lys Leu Tyr Gln Lys Leu 
225                 230                 235                 240 


Asn Phe Arg Val Val Leu Val Gly Leu Glu Ile Trp Asn Ser Gln Asp 
                245                 250                 255     


Arg Phe His Val Ser Pro Asp Pro Ser Val Thr Leu Glu Asn Leu Leu 
            260                 265                 270         


Thr Trp Gln Ala Arg Gln Arg Thr Arg Arg His Leu His Asp Asn Val 
        275                 280                 285             


Gln Leu Ile Thr Gly Val Asp Phe Thr Gly Thr Thr Val Gly Phe Ala 
    290                 295                 300                 


Arg Val Ser Ala Met Cys Ser His Ser Ser Gly Ala Val Asn Gln Asp 
305                 310                 315                 320 


His Ser Lys Asn Pro Val Gly Val Ala Cys Thr Met Ala His Glu Met 
                325                 330                 335     


Gly His Asn Leu Gly Met Asp His Asp Glu Asn Val Gln Gly Cys Arg 
            340                 345                 350         


Cys Gln Glu Arg Phe Glu Ala Gly Arg Cys Ile Met Ala Gly Ser Ile 
        355                 360                 365             


Gly Ser Ser Phe Pro Arg Met Phe Ser Asp Cys Ser Gln Ala Tyr Leu 
    370                 375                 380                 


Glu Ser Phe Leu Glu Arg Pro Gln Ser Val Cys Leu Ala Asn Ala Pro 
385                 390                 395                 400 


Asp Leu Ser His Leu Val Gly Gly Pro Val Cys Gly Asn Leu Phe Val 
                405                 410                 415     


Glu Arg Gly Glu Gln Cys Asp Cys Gly Pro Pro Glu Asp Cys Arg Asn 
            420                 425                 430         


Arg Cys Cys Asn Ser Thr Thr Cys Gln Leu Ala Glu Gly Ala Gln Cys 
        435                 440                 445             


Ala His Gly Thr Cys Cys Gln Glu Cys Lys Val Lys Pro Ala Gly Glu 
    450                 455                 460                 


Leu Cys Arg Pro Lys Lys Asp Met Cys Asp Leu Glu Glu Phe Cys Asp 
465                 470                 475                 480 


Gly Arg His Pro Glu Cys Pro Glu Asp Ala Phe Gln Glu Asn Gly Thr 
                485                 490                 495     


Pro Cys Ser Gly Gly Tyr Cys Tyr Asn Gly Ala Cys Pro Thr Leu Ala 
            500                 505                 510         


Gln Gln Cys Gln Ala Phe Trp Gly Pro Gly Gly Gln Ala Ala Glu Glu 
        515                 520                 525             


Ser Cys Phe Ser Tyr Asp Ile Leu Pro Gly Cys Lys Ala Ser Arg Tyr 
    530                 535                 540                 


Arg Ala Asp Met Cys Gly Val Leu Gln Cys Lys Gly Gly Gln Gln Pro 
545                 550                 555                 560 


Leu Gly Arg Ala Ile Cys Ile Val Asp Val Cys His Ala Leu Thr Thr 
                565                 570                 575     


Glu Asp Gly Thr Ala Tyr Glu Pro Val Pro Glu Gly Thr Arg Cys Gly 
            580                 585                 590         


Pro Glu Lys Val Cys Trp Lys Gly Arg Cys Gln Asp Leu His Val Tyr 
        595                 600                 605             


Arg Ser Ser Asn Cys Ser Ala Gln Cys His Asn His Gly Val Cys Asn 
    610                 615                 620                 


His Lys Gln Glu Cys His Cys His Ala Gly Trp Ala Pro Pro His Cys 
625                 630                 635                 640 


Ala Lys Leu Leu Thr Glu Val His Ala Gly Cys Gln Pro Arg Ala Gly 
                645                 650                 655     


Gln Gly Arg Gly Ser Ser Pro Ile Gln Gly Pro Pro Arg Ala Gly Pro 
            660                 665                 670         


His His Pro Pro Gly Pro Ala Arg Pro Thr Pro Gly Leu Leu Gly Gly 
        675                 680                 685             


Ser Glu Glu Ala Ala Pro Cys Ser Ser Gly His Cys Val Gln Pro Thr 
    690                 695                 700                 


Leu Pro Ser Ser Cys Leu His Pro Ala Gly Thr Lys Ala Gly His Gln 
705                 710                 715                 720 


Ala Asn Val Arg Thr Pro Ser Ala Pro Ser Gln Thr Arg Gly Trp Cys 
                725                 730                 735     


Gly Gln Pro Trp Ser Ser 
            740         


<210>  2085
<211>  733
<212>  PRT
<213>  Homo sapiens

<400>  2085

Met Arg Gly Leu Gly Leu Trp Leu Leu Gly Ala Met Met Leu Pro Gly 
1               5                   10                  15      


Pro Ala Pro Arg Glu Gly Glu Leu Arg Pro Trp Gly His Arg Ala Gln 
            20                  25                  30          


Leu His Pro Pro Pro Ala Glu Glu Gln Gly Pro Ala Gly Leu Arg Leu 
        35                  40                  45              


His Arg Asp Leu Tyr Gly Cys Gln Trp Leu Arg Gly Asp Gly Ala Ala 
    50                  55                  60                  


Ser Arg Ala Gly Pro Leu Leu Leu Pro Gly Pro Arg Arg Gly Val Pro 
65                  70                  75                  80  


Gly Leu Ser Arg Gln Pro Gln His Leu Cys Arg Pro Gln Val Gly Ser 
                85                  90                  95      


Asp Leu His Leu Ile Glu Pro Leu Asp Glu Gly Gly Glu Gly Gly Arg 
            100                 105                 110         


His Ala Val Tyr Gln Ala Glu His Leu Leu Gln Thr Ala Gly Thr Cys 
        115                 120                 125             


Gly Val Ser Asp Asp Ser Leu Gly Ser Leu Leu Gly Pro Arg Thr Ala 
    130                 135                 140                 


Ala Val Phe Arg Pro Arg Pro Gly Asp Ser Leu Pro Ser Arg Glu Thr 
145                 150                 155                 160 


Arg Tyr Val Glu Leu Tyr Val Val Val Asp Asn Ala Glu Phe Gln Met 
                165                 170                 175     


Leu Gly Ser Glu Ala Ala Val Arg His Arg Val Leu Glu Val Val Asn 
            180                 185                 190         


His Val Asp Lys Leu Tyr Gln Lys Leu Asn Phe Arg Val Val Leu Val 
        195                 200                 205             


Gly Leu Glu Ile Trp Asn Ser Gln Asp Arg Phe His Val Ser Pro Asp 
    210                 215                 220                 


Pro Ser Val Thr Leu Glu Asn Leu Leu Thr Trp Gln Ala Arg Gln Arg 
225                 230                 235                 240 


Thr Arg Arg His Leu His Asp Asn Val Gln Leu Ile Thr Gly Val Asp 
                245                 250                 255     


Phe Thr Gly Thr Thr Val Gly Phe Ala Arg Val Ser Ala Met Cys Ser 
            260                 265                 270         


His Ser Ser Gly Ala Val Asn Gln Asp His Ser Lys Asn Pro Val Gly 
        275                 280                 285             


Val Ala Cys Thr Met Ala His Glu Met Gly His Asn Leu Gly Met Asp 
    290                 295                 300                 


His Asp Glu Asn Val Gln Gly Cys Arg Cys Gln Glu Arg Phe Glu Ala 
305                 310                 315                 320 


Gly Arg Cys Ile Met Ala Gly Ser Ile Gly Ser Ser Phe Pro Arg Met 
                325                 330                 335     


Phe Ser Asp Cys Ser Gln Ala Tyr Leu Glu Ser Phe Leu Glu Arg Pro 
            340                 345                 350         


Gln Ser Val Cys Leu Ala Asn Ala Pro Asp Leu Ser His Leu Val Gly 
        355                 360                 365             


Gly Pro Val Cys Gly Asn Leu Phe Val Glu Arg Gly Glu Gln Cys Asp 
    370                 375                 380                 


Cys Gly Pro Pro Glu Asp Cys Arg Asn Arg Cys Cys Asn Ser Thr Thr 
385                 390                 395                 400 


Cys Gln Leu Ala Glu Gly Ala Gln Cys Ala His Gly Thr Cys Cys Gln 
                405                 410                 415     


Glu Cys Lys Val Lys Pro Ala Gly Glu Leu Cys Arg Pro Lys Lys Asp 
            420                 425                 430         


Met Cys Asp Leu Glu Glu Phe Cys Asp Gly Arg His Pro Glu Cys Pro 
        435                 440                 445             


Glu Asp Ala Phe Gln Glu Asn Gly Thr Pro Cys Ser Gly Gly Tyr Cys 
    450                 455                 460                 


Tyr Asn Gly Ala Cys Pro Thr Leu Ala Gln Gln Cys Gln Ala Phe Trp 
465                 470                 475                 480 


Gly Pro Gly Gly Gln Ala Ala Glu Glu Ser Cys Phe Ser Tyr Asp Ile 
                485                 490                 495     


Leu Pro Gly Cys Lys Ala Ser Arg Tyr Arg Ala Asp Met Cys Gly Val 
            500                 505                 510         


Leu Gln Cys Lys Gly Gly Gln Gln Pro Leu Gly Arg Ala Ile Cys Ile 
        515                 520                 525             


Val Asp Val Cys His Ala Leu Thr Thr Glu Asp Gly Thr Ala Tyr Glu 
    530                 535                 540                 


Pro Val Pro Glu Gly Thr Arg Cys Gly Pro Glu Lys Val Cys Asn His 
545                 550                 555                 560 


Lys Gln Glu Cys His Cys His Ala Gly Trp Ala Pro Pro His Cys Ala 
                565                 570                 575     


Lys Leu Leu Thr Glu Val His Ala Ala Ser Gly Ser Leu Pro Val Phe 
            580                 585                 590         


Val Val Val Val Leu Val Leu Leu Ala Val Val Leu Val Thr Leu Ala 
        595                 600                 605             


Gly Ile Ile Val Tyr Arg Lys Ala Arg Ser Arg Ile Leu Ser Arg Asn 
    610                 615                 620                 


Val Ala Pro Lys Thr Thr Met Gly Arg Ser Asn Pro Leu Phe His Gln 
625                 630                 635                 640 


Ala Ala Ser Arg Val Pro Ala Lys Gly Gly Ala Pro Ala Pro Ser Arg 
                645                 650                 655     


Gly Pro Gln Glu Leu Val Pro Thr Thr His Pro Gly Gln Pro Ala Arg 
            660                 665                 670         


His Pro Ala Ser Ser Val Ala Leu Lys Arg Pro Pro Pro Ala Pro Pro 
        675                 680                 685             


Val Thr Val Ser Ser Pro Pro Phe Pro Val Pro Val Tyr Thr Arg Gln 
    690                 695                 700                 


Ala Pro Lys Gln Gly Ala Val Gly Pro Lys Val Ala Leu Lys Pro Pro 
705                 710                 715                 720 


Ile Gln Arg Lys Gln Gly Ala Gly Ala Pro Thr Ala Pro 
                725                 730             


<210>  2086
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  2086

Met Ser Pro Ser Gly Arg Leu Cys Leu Leu Thr Ile Val Gly Leu Ile 
1               5                   10                  15      


Leu Pro Thr Arg Gly Gln Thr Leu Lys Asp Thr Thr Ser Ser Ser Ser 
            20                  25                  30          


Ala Asp Ser Thr Ile Met Asp Ile Gln Val Pro Thr Arg Ala Pro Asp 
        35                  40                  45              


Ala Val Tyr Thr Glu Leu Gln Pro Thr Ser Pro Thr Pro Thr Trp Pro 
    50                  55                  60                  


Ala Asp Glu Thr Pro Gln Pro Gln Thr Gln Thr Gln Gln Leu Glu Gly 
65                  70                  75                  80  


Thr Asp Gly Pro Leu Val Thr Asp Pro Glu Thr His Lys Ser Thr Lys 
                85                  90                  95      


Ala Ala His Pro Thr Asp Asp Thr Thr Thr Leu Ser Glu Arg Pro Ser 
            100                 105                 110         


Pro Ser Thr Asp Val Gln Thr Asp Pro Gln Thr Leu Lys Pro Ser Gly 
        115                 120                 125             


Phe His Glu Asp Asp Pro Phe Phe Tyr Asp Glu His Thr Leu Arg Lys 
    130                 135                 140                 


Arg Gly Leu Leu Val Ala Ala Val Leu Phe Ile Thr Gly Ile Ile Ile 
145                 150                 155                 160 


Leu Thr Ser Gly Lys Cys Arg Gln Leu Ser Arg Leu Cys Arg Asn Arg 
                165                 170                 175     


Cys Arg 
        


<210>  2087
<211>  706
<212>  PRT
<213>  Homo sapiens

<400>  2087

Met Glu Met Phe Thr Phe Leu Leu Thr Cys Ile Phe Leu Pro Leu Leu 
1               5                   10                  15      


Arg Gly His Ser Leu Phe Thr Cys Glu Pro Ile Thr Val Pro Arg Cys 
            20                  25                  30          


Met Lys Met Ala Tyr Asn Met Thr Phe Phe Pro Asn Leu Met Gly His 
        35                  40                  45              


Tyr Asp Gln Ser Ile Ala Ala Val Glu Met Glu His Phe Leu Pro Leu 
    50                  55                  60                  


Ala Asn Leu Glu Cys Ser Pro Asn Ile Glu Thr Phe Leu Cys Lys Ala 
65                  70                  75                  80  


Phe Val Pro Thr Cys Ile Glu Gln Ile His Val Val Pro Pro Cys Arg 
                85                  90                  95      


Lys Leu Cys Glu Lys Val Tyr Ser Asp Cys Lys Lys Leu Ile Asp Thr 
            100                 105                 110         


Phe Gly Ile Arg Trp Pro Glu Glu Leu Glu Cys Asp Arg Leu Gln Tyr 
        115                 120                 125             


Cys Asp Glu Thr Val Pro Val Thr Phe Asp Pro His Thr Glu Phe Leu 
    130                 135                 140                 


Gly Pro Gln Lys Lys Thr Glu Gln Val Gln Arg Asp Ile Gly Phe Trp 
145                 150                 155                 160 


Cys Pro Arg His Leu Lys Thr Ser Gly Gly Gln Gly Tyr Lys Phe Leu 
                165                 170                 175     


Gly Ile Asp Gln Cys Ala Pro Pro Cys Pro Asn Met Tyr Phe Lys Ser 
            180                 185                 190         


Asp Glu Leu Glu Phe Ala Lys Ser Phe Ile Gly Thr Val Ser Ile Phe 
        195                 200                 205             


Cys Leu Cys Ala Thr Leu Phe Thr Phe Leu Thr Phe Leu Ile Asp Val 
    210                 215                 220                 


Arg Arg Phe Arg Tyr Pro Glu Arg Pro Ile Ile Tyr Tyr Ser Val Cys 
225                 230                 235                 240 


Tyr Ser Ile Val Ser Leu Met Tyr Phe Ile Gly Phe Leu Leu Gly Asp 
                245                 250                 255     


Ser Thr Ala Cys Asn Lys Ala Asp Glu Lys Leu Glu Leu Gly Asp Thr 
            260                 265                 270         


Val Val Leu Gly Ser Gln Asn Lys Ala Cys Thr Val Leu Phe Met Leu 
        275                 280                 285             


Leu Tyr Phe Phe Thr Met Ala Gly Thr Val Trp Trp Val Ile Leu Thr 
    290                 295                 300                 


Ile Thr Trp Phe Leu Ala Ala Gly Arg Lys Trp Ser Cys Glu Ala Ile 
305                 310                 315                 320 


Glu Gln Lys Ala Val Trp Phe His Ala Val Ala Trp Gly Thr Pro Gly 
                325                 330                 335     


Phe Leu Thr Val Met Leu Leu Ala Met Asn Lys Val Glu Gly Asp Asn 
            340                 345                 350         


Ile Ser Gly Val Cys Phe Val Gly Leu Tyr Asp Leu Asp Ala Ser Arg 
        355                 360                 365             


Tyr Phe Val Leu Leu Pro Leu Cys Leu Cys Val Phe Val Gly Leu Ser 
    370                 375                 380                 


Leu Leu Leu Ala Gly Ile Ile Ser Leu Asn His Val Arg Gln Val Ile 
385                 390                 395                 400 


Gln His Asp Gly Arg Asn Gln Glu Lys Leu Lys Lys Phe Met Ile Arg 
                405                 410                 415     


Ile Gly Val Phe Ser Gly Leu Tyr Leu Val Pro Leu Val Thr Leu Leu 
            420                 425                 430         


Gly Cys Tyr Val Tyr Glu Gln Val Asn Arg Ile Thr Trp Glu Ile Thr 
        435                 440                 445             


Trp Val Ser Asp His Cys Arg Gln Tyr His Ile Pro Cys Pro Tyr Gln 
    450                 455                 460                 


Ala Lys Ala Lys Ala Arg Pro Glu Leu Ala Leu Phe Met Ile Lys Tyr 
465                 470                 475                 480 


Leu Met Thr Leu Ile Val Gly Ile Ser Ala Val Phe Trp Val Gly Ser 
                485                 490                 495     


Lys Lys Thr Cys Thr Glu Trp Ala Gly Phe Phe Lys Arg Asn Arg Lys 
            500                 505                 510         


Arg Asp Pro Ile Ser Glu Ser Arg Arg Val Leu Gln Glu Ser Cys Glu 
        515                 520                 525             


Phe Phe Leu Lys His Asn Ser Lys Val Lys His Lys Lys Lys His Tyr 
    530                 535                 540                 


Lys Pro Ser Ser His Lys Leu Lys Val Ile Ser Lys Ser Met Gly Thr 
545                 550                 555                 560 


Ser Thr Gly Ala Thr Ala Asn His Gly Thr Ser Ala Val Ala Ile Thr 
                565                 570                 575     


Ser His Asp Tyr Leu Gly Gln Glu Thr Leu Thr Glu Ile Gln Thr Ser 
            580                 585                 590         


Pro Glu Thr Ser Met Arg Glu Val Lys Ala Asp Gly Ala Ser Thr Pro 
        595                 600                 605             


Arg Leu Arg Glu Gln Asp Cys Gly Glu Pro Ala Ser Pro Ala Ala Ser 
    610                 615                 620                 


Ile Ser Arg Leu Ser Gly Glu Gln Val Asp Gly Lys Gly Gln Ala Gly 
625                 630                 635                 640 


Ser Val Ser Glu Ser Ala Arg Ser Glu Gly Arg Ile Ser Pro Lys Ser 
                645                 650                 655     


Asp Ile Thr Asp Thr Gly Leu Ala Gln Ser Asn Asn Leu Gln Val Pro 
            660                 665                 670         


Ser Ser Ser Glu Pro Ser Ser Leu Lys Gly Ser Thr Ser Leu Leu Val 
        675                 680                 685             


His Pro Val Ser Gly Val Arg Lys Glu Gln Gly Gly Gly Cys His Ser 
    690                 695                 700                 


Asp Thr 
705     


<210>  2088
<211>  674
<212>  PRT
<213>  Homo sapiens

<400>  2088

Met Lys Met Ala Tyr Asn Met Thr Phe Phe Pro Asn Leu Met Gly His 
1               5                   10                  15      


Tyr Asp Gln Ser Ile Ala Ala Val Glu Met Glu His Phe Leu Pro Leu 
            20                  25                  30          


Ala Asn Leu Glu Cys Ser Pro Asn Ile Glu Thr Phe Leu Cys Lys Ala 
        35                  40                  45              


Phe Val Pro Thr Cys Ile Glu Gln Ile His Val Val Pro Pro Cys Arg 
    50                  55                  60                  


Lys Leu Cys Glu Lys Val Tyr Ser Asp Cys Lys Lys Leu Ile Asp Thr 
65                  70                  75                  80  


Phe Gly Ile Arg Trp Pro Glu Glu Leu Glu Cys Asp Arg Leu Gln Tyr 
                85                  90                  95      


Cys Asp Glu Thr Val Pro Val Thr Phe Asp Pro His Thr Glu Phe Leu 
            100                 105                 110         


Gly Pro Gln Lys Lys Thr Glu Gln Val Gln Arg Asp Ile Gly Phe Trp 
        115                 120                 125             


Cys Pro Arg His Leu Lys Thr Ser Gly Gly Gln Gly Tyr Lys Phe Leu 
    130                 135                 140                 


Gly Ile Asp Gln Cys Ala Pro Pro Cys Pro Asn Met Tyr Phe Lys Ser 
145                 150                 155                 160 


Asp Glu Leu Glu Phe Ala Lys Ser Phe Ile Gly Thr Val Ser Ile Phe 
                165                 170                 175     


Cys Leu Cys Ala Thr Leu Phe Thr Phe Leu Thr Phe Leu Ile Asp Val 
            180                 185                 190         


Arg Arg Phe Arg Tyr Pro Glu Arg Pro Ile Ile Tyr Tyr Ser Val Cys 
        195                 200                 205             


Tyr Ser Ile Val Ser Leu Met Tyr Phe Ile Gly Phe Leu Leu Gly Asp 
    210                 215                 220                 


Ser Thr Ala Cys Asn Lys Ala Asp Glu Lys Leu Glu Leu Gly Asp Thr 
225                 230                 235                 240 


Val Val Leu Gly Ser Gln Asn Lys Ala Cys Thr Val Leu Phe Met Leu 
                245                 250                 255     


Leu Tyr Phe Phe Thr Met Ala Gly Thr Val Trp Trp Val Ile Leu Thr 
            260                 265                 270         


Ile Thr Trp Phe Leu Ala Ala Gly Arg Lys Trp Ser Cys Glu Ala Ile 
        275                 280                 285             


Glu Gln Lys Ala Val Trp Phe His Ala Val Ala Trp Gly Thr Pro Gly 
    290                 295                 300                 


Phe Leu Thr Val Met Leu Leu Ala Met Asn Lys Val Glu Gly Asp Asn 
305                 310                 315                 320 


Ile Ser Gly Val Cys Phe Val Gly Leu Tyr Asp Leu Asp Ala Ser Arg 
                325                 330                 335     


Tyr Phe Val Leu Leu Pro Leu Cys Leu Cys Val Phe Val Gly Leu Ser 
            340                 345                 350         


Leu Leu Leu Ala Gly Ile Ile Ser Leu Asn His Val Arg Gln Val Ile 
        355                 360                 365             


Gln His Asp Gly Arg Asn Gln Glu Lys Leu Lys Lys Phe Met Ile Arg 
    370                 375                 380                 


Ile Gly Val Phe Ser Gly Leu Tyr Leu Val Pro Leu Val Thr Leu Leu 
385                 390                 395                 400 


Gly Cys Tyr Val Tyr Glu Gln Val Asn Arg Ile Thr Trp Glu Ile Thr 
                405                 410                 415     


Trp Val Ser Asp His Cys Arg Gln Tyr His Ile Pro Cys Pro Tyr Gln 
            420                 425                 430         


Ala Lys Ala Lys Ala Arg Pro Glu Leu Ala Leu Phe Met Ile Lys Tyr 
        435                 440                 445             


Leu Met Thr Leu Ile Val Gly Ile Ser Ala Val Phe Trp Val Gly Ser 
    450                 455                 460                 


Lys Lys Thr Cys Thr Glu Trp Ala Gly Phe Phe Lys Arg Asn Arg Lys 
465                 470                 475                 480 


Arg Asp Pro Ile Ser Glu Ser Arg Arg Val Leu Gln Glu Ser Cys Glu 
                485                 490                 495     


Phe Phe Leu Lys His Asn Ser Lys Val Lys His Lys Lys Lys His Tyr 
            500                 505                 510         


Lys Pro Ser Ser His Lys Leu Lys Val Ile Ser Lys Ser Met Gly Thr 
        515                 520                 525             


Ser Thr Gly Ala Thr Ala Asn His Gly Thr Ser Ala Val Ala Ile Thr 
    530                 535                 540                 


Ser His Asp Tyr Leu Gly Gln Glu Thr Leu Thr Glu Ile Gln Thr Ser 
545                 550                 555                 560 


Pro Glu Thr Ser Met Arg Glu Val Lys Ala Asp Gly Ala Ser Thr Pro 
                565                 570                 575     


Arg Leu Arg Glu Gln Asp Cys Gly Glu Pro Ala Ser Pro Ala Ala Ser 
            580                 585                 590         


Ile Ser Arg Leu Ser Gly Glu Gln Val Asp Gly Lys Gly Gln Ala Gly 
        595                 600                 605             


Ser Val Ser Glu Ser Ala Arg Ser Glu Gly Arg Ile Ser Pro Lys Ser 
    610                 615                 620                 


Asp Ile Thr Asp Thr Gly Leu Ala Gln Ser Asn Asn Leu Gln Val Pro 
625                 630                 635                 640 


Ser Ser Ser Glu Pro Ser Ser Leu Lys Gly Ser Thr Ser Leu Leu Val 
                645                 650                 655     


His Pro Val Ser Gly Val Arg Lys Glu Gln Gly Gly Gly Cys His Ser 
            660                 665                 670         


Asp Thr 
        


<210>  2089
<211>  603
<212>  PRT
<213>  Homo sapiens

<400>  2089

Met Ala Gly Thr Val Arg Thr Ala Cys Leu Val Val Ala Met Leu Leu 
1               5                   10                  15      


Ser Leu Asp Phe Pro Gly Gln Ala Gln Pro Pro Pro Pro Pro Pro Asp 
            20                  25                  30          


Ala Thr Cys His Gln Val Arg Ser Phe Phe Gln Arg Leu Gln Pro Gly 
        35                  40                  45              


Leu Lys Trp Val Pro Glu Thr Pro Val Pro Gly Ser Asp Leu Gln Val 
    50                  55                  60                  


Cys Leu Pro Lys Gly Pro Thr Cys Cys Ser Arg Lys Met Glu Glu Lys 
65                  70                  75                  80  


Tyr Gln Leu Thr Ala Arg Leu Asn Met Glu Gln Leu Leu Gln Ser Ala 
                85                  90                  95      


Ser Met Glu Leu Lys Phe Leu Ile Ile Gln Asn Ala Ala Val Phe Gln 
            100                 105                 110         


Glu Ala Phe Glu Ile Val Val Arg His Ala Lys Asn Tyr Thr Asn Ala 
        115                 120                 125             


Met Phe Lys Asn Asn Tyr Pro Ser Leu Thr Pro Gln Ala Phe Glu Phe 
    130                 135                 140                 


Val Gly Glu Phe Phe Thr Asp Val Ser Leu Tyr Ile Leu Gly Ser Asp 
145                 150                 155                 160 


Ile Asn Val Asp Asp Met Val Asn Glu Leu Phe Asp Ser Leu Phe Pro 
                165                 170                 175     


Val Ile Tyr Thr Gln Leu Met Asn Pro Gly Leu Pro Asp Ser Ala Leu 
            180                 185                 190         


Asp Ile Asn Glu Cys Leu Arg Gly Ala Arg Arg Asp Leu Lys Val Phe 
        195                 200                 205             


Gly Asn Phe Pro Lys Leu Ile Met Thr Gln Val Ser Lys Ser Leu Gln 
    210                 215                 220                 


Val Thr Arg Ile Phe Leu Gln Ala Leu Asn Leu Gly Ile Glu Val Ile 
225                 230                 235                 240 


Asn Thr Thr Asp His Leu Lys Phe Ser Lys Asp Cys Gly Arg Met Leu 
                245                 250                 255     


Thr Arg Met Trp Tyr Cys Ser Tyr Cys Gln Gly Leu Met Met Val Lys 
            260                 265                 270         


Pro Cys Gly Gly Tyr Cys Asn Val Val Met Gln Gly Cys Met Ala Gly 
        275                 280                 285             


Val Val Glu Ile Asp Lys Tyr Trp Arg Glu Tyr Ile Leu Ser Leu Glu 
    290                 295                 300                 


Glu Leu Val Asn Gly Met Tyr Arg Ile Tyr Asp Met Glu Asn Val Leu 
305                 310                 315                 320 


Leu Gly Leu Phe Ser Thr Ile His Asp Ser Ile Gln Tyr Val Gln Lys 
                325                 330                 335     


Asn Ala Gly Lys Leu Thr Thr Thr Glu Thr Glu Lys Lys Ile Trp His 
            340                 345                 350         


Phe Lys Tyr Pro Ile Phe Phe Leu Cys Ile Gly Leu Asp Leu Gln Ile 
        355                 360                 365             


Gly Lys Leu Cys Ala His Ser Gln Gln Arg Gln Tyr Arg Ser Ala Tyr 
    370                 375                 380                 


Tyr Pro Glu Asp Leu Phe Ile Asp Lys Lys Val Leu Lys Val Ala His 
385                 390                 395                 400 


Val Glu His Glu Glu Thr Leu Ser Ser Arg Arg Arg Glu Leu Ile Gln 
                405                 410                 415     


Lys Leu Lys Ser Phe Ile Ser Phe Tyr Ser Ala Leu Pro Gly Tyr Ile 
            420                 425                 430         


Cys Ser His Ser Pro Val Ala Glu Asn Asp Thr Leu Cys Trp Asn Gly 
        435                 440                 445             


Gln Glu Leu Val Glu Arg Tyr Ser Gln Lys Ala Ala Arg Asn Gly Met 
    450                 455                 460                 


Lys Asn Gln Phe Asn Leu His Glu Leu Lys Met Lys Gly Pro Glu Pro 
465                 470                 475                 480 


Val Val Ser Gln Ile Ile Asp Lys Leu Lys His Ile Asn Gln Leu Leu 
                485                 490                 495     


Arg Thr Met Ser Met Pro Lys Gly Arg Val Leu Asp Lys Asn Leu Asp 
            500                 505                 510         


Glu Glu Gly Phe Glu Ser Gly Asp Cys Gly Asp Asp Glu Asp Glu Cys 
        515                 520                 525             


Ile Gly Gly Ser Gly Asp Gly Met Ile Lys Val Lys Asn Gln Leu Arg 
    530                 535                 540                 


Phe Leu Ala Glu Leu Ala Tyr Asp Leu Asp Val Asp Asp Ala Pro Gly 
545                 550                 555                 560 


Asn Ser Gln Gln Ala Thr Pro Lys Asp Asn Glu Ile Ser Thr Phe His 
                565                 570                 575     


Asn Leu Gly Asn Val His Ser Pro Leu Lys Leu Leu Thr Ser Met Ala 
            580                 585                 590         


Ile Ser Val Val Cys Phe Phe Phe Leu Val His 
        595                 600             


<210>  2090
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  2090

Met Ala Gly Thr Val Arg Thr Ala Cys Leu Val Val Ala Met Leu Leu 
1               5                   10                  15      


Ser Leu Asp Phe Pro Gly Gln Ala Gln Pro Pro Pro Pro Pro Pro Asp 
            20                  25                  30          


Ala Thr Cys His Gln Val Arg Ser Phe Phe Gln Arg Leu Gln Pro Gly 
        35                  40                  45              


Leu Lys Trp Val Pro Glu Thr Pro Val Pro Gly Ser Asp Leu Gln Val 
    50                  55                  60                  


Cys Leu Pro Lys Gly Pro Thr Cys Cys Ser Arg Lys Met Glu Glu Lys 
65                  70                  75                  80  


Tyr Gln Leu Thr Ala Arg Leu Asn Met Glu Gln Leu Leu Gln Ser Ala 
                85                  90                  95      


Lys Ala Phe Glu Ile Val Val Arg His Ala Lys Asn Tyr Thr Asn Ala 
            100                 105                 110         


Met Phe Lys Asn Asn Tyr Pro Ser Leu Thr Pro Gln Ala Phe Glu Phe 
        115                 120                 125             


Val Gly Glu Phe Phe Thr Asp Val Ser Leu Tyr Ile Leu Gly Ser Asp 
    130                 135                 140                 


Ile Asn Val Asp Asp Met Val Asn Glu Leu Phe Asp Ser Leu Phe Pro 
145                 150                 155                 160 


Val Ile Tyr Thr Gln Leu Met Asn Pro Gly Leu Pro Asp Ser Ala Leu 
                165                 170                 175     


Asp Ile Asn Glu Cys Leu Arg Gly Ala Arg Arg Asp Leu Lys Val Phe 
            180                 185                 190         


Gly Asn Phe Pro Lys Leu Ile Met Thr Gln Val Ser Lys Ser Leu Gln 
        195                 200                 205             


Val Thr Arg Ile Phe Leu Gln Ala Leu Asn Leu Gly Ile Glu Val Ile 
    210                 215                 220                 


Asn Thr Thr Asp His Leu Lys Phe Ser Lys Asp Cys Gly Arg Met Leu 
225                 230                 235                 240 


Thr Arg Met Trp Tyr Cys Ser Tyr Cys Gln Gly Leu Met Met Val Lys 
                245                 250                 255     


Pro Cys Gly Gly Tyr Cys Asn Val Val Met Gln Gly Cys Met Ala Gly 
            260                 265                 270         


Val Val Glu Ile Asp Lys Tyr Trp Arg Glu Tyr Ile Leu Ser Leu Glu 
        275                 280                 285             


Glu Leu Val Asn Gly Met Tyr Arg Ile Tyr Asp Met Glu Asn Val Leu 
    290                 295                 300                 


Leu Gly Leu Phe Ser Thr Ile His Asp Ser Ile Gln Tyr Val Gln Lys 
305                 310                 315                 320 


Asn Ala Gly Lys Leu Thr Thr Thr Ile Gly Lys Leu Cys Ala His Ser 
                325                 330                 335     


Gln Gln Arg Gln Tyr Arg Ser Ala Tyr Tyr Pro Glu Asp Leu Phe Ile 
            340                 345                 350         


Asp Lys Lys Val Leu Lys Val Ala His Val Glu His Glu Glu Thr Leu 
        355                 360                 365             


Ser Ser Arg Arg Arg Glu Leu Ile Gln Lys Leu Lys Ser Phe Ile Ser 
    370                 375                 380                 


Phe Tyr Ser Ala Leu Pro Gly Tyr Ile Cys Ser His Ser Pro Val Ala 
385                 390                 395                 400 


Glu Asn Asp Thr Leu Cys Trp Asn Gly Gln Glu Leu Val Glu Arg Tyr 
                405                 410                 415     


Ser Gln Lys Ala Ala Arg Asn Gly Met Lys Asn Gln Phe Asn Leu His 
            420                 425                 430         


Glu Leu Lys Met Lys Gly Pro Glu Pro Val Val Ser Gln Ile Ile Asp 
        435                 440                 445             


Lys Leu Lys His Ile Asn Gln Leu Leu Arg Thr Met Ser Met Pro Lys 
    450                 455                 460                 


Gly Arg Val Leu Asp Lys Asn Leu Asp Glu Glu Gly Phe Glu Ser Gly 
465                 470                 475                 480 


Asp Cys Gly Asp Asp Glu Asp Glu Cys Ile Gly Gly Ser Gly Asp Gly 
                485                 490                 495     


Met Ile Lys Val Lys Asn Gln Leu Arg Phe Leu Ala Glu Leu Ala Tyr 
            500                 505                 510         


Asp Leu Asp Val Asp Asp Ala Pro Gly Asn Ser Gln Gln Ala Thr Pro 
        515                 520                 525             


Lys Asp Asn Glu Ile Ser Thr Phe His Asn Leu Gly Asn Val His Ser 
    530                 535                 540                 


Pro Leu Lys Leu Leu Thr Ser Met Ala Ile Ser Val Val Cys Phe Phe 
545                 550                 555                 560 


Phe Leu Val His 
                


<210>  2091
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  2091

Met Ala Gly Thr Val Arg Thr Ala Cys Leu Val Val Ala Met Leu Leu 
1               5                   10                  15      


Ser Leu Asp Phe Pro Gly Gln Ala Gln Pro Pro Pro Pro Pro Pro Asp 
            20                  25                  30          


Ala Thr Cys His Gln Val Arg Ser Phe Phe Gln Arg Leu Gln Pro Gly 
        35                  40                  45              


Leu Lys Trp Val Pro Glu Thr Pro Val Pro Glu Ala Phe Glu Ile Val 
    50                  55                  60                  


Val Arg His Ala Lys Asn Tyr Thr Asn Ala Met Phe Lys Asn Asn Tyr 
65                  70                  75                  80  


Pro Ser Leu Thr Pro Gln Ala Phe Glu Phe Val Gly Glu Phe Phe Thr 
                85                  90                  95      


Asp Val Ser Leu Tyr Ile Leu Gly Ser Asp Ile Asn Val Asp Asp Met 
            100                 105                 110         


Val Asn Glu Leu Phe Asp Ser Leu Phe Pro Val Ile Tyr Thr Gln Leu 
        115                 120                 125             


Met Asn Pro Gly Leu Pro Asp Ser Ala Leu Asp Ile Asn Glu Cys Leu 
    130                 135                 140                 


Arg Gly Ala Arg Arg Asp Leu Lys Val Phe Gly Asn Phe Pro Lys Leu 
145                 150                 155                 160 


Ile Met Thr Gln Val Ser Lys Ser Leu Gln Val Thr Arg Ile Phe Leu 
                165                 170                 175     


Gln Ala Leu Asn Leu Gly Ile Glu Val Ile Asn Thr Thr Asp His Leu 
            180                 185                 190         


Lys Phe Ser Lys Asp Cys Gly Arg Met Leu Thr Arg Met Trp Tyr Cys 
        195                 200                 205             


Ser Tyr Cys Gln Gly Leu Met Met Val Lys Pro Cys Gly Gly Tyr Cys 
    210                 215                 220                 


Asn Val Val Met Gln Gly Cys Met Ala Gly Val Val Glu Ile Asp Lys 
225                 230                 235                 240 


Tyr Trp Arg Glu Tyr Ile Leu Ser Leu Glu Glu Leu Val Asn Gly Met 
                245                 250                 255     


Tyr Arg Ile Tyr Asp Met Glu Asn Val Leu Leu Gly Leu Phe Ser Thr 
            260                 265                 270         


Ile His Asp Ser Ile Gln Tyr Val Gln Lys Asn Ala Gly Lys Leu Thr 
        275                 280                 285             


Thr Thr Ile Gly Lys Leu Cys Ala His Ser Gln Gln Arg Gln Tyr Arg 
    290                 295                 300                 


Ser Ala Tyr Tyr Pro Glu Asp Leu Phe Ile Asp Lys Lys Val Leu Lys 
305                 310                 315                 320 


Val Ala His Val Glu His Glu Glu Thr Leu Ser Ser Arg Arg Arg Glu 
                325                 330                 335     


Leu Ile Gln Lys Leu Lys Ser Phe Ile Ser Phe Tyr Ser Ala Leu Pro 
            340                 345                 350         


Gly Tyr Ile Cys Ser His Ser Pro Val Ala Glu Asn Asp Thr Leu Cys 
        355                 360                 365             


Trp Asn Gly Gln Glu Leu Val Glu Arg Tyr Ser Gln Lys Ala Ala Arg 
    370                 375                 380                 


Asn Gly Met Lys Asn Gln Phe Asn Leu His Glu Leu Lys Met Lys Gly 
385                 390                 395                 400 


Pro Glu Pro Val Val Ser Gln Ile Ile Asp Lys Leu Lys His Ile Asn 
                405                 410                 415     


Gln Leu Leu Arg Thr Met Ser Met Pro Lys Gly Arg Val Leu Asp Lys 
            420                 425                 430         


Asn Leu Asp Glu Glu Gly Phe Glu Ser Gly Asp Cys Gly Asp Asp Glu 
        435                 440                 445             


Asp Glu Cys Ile Gly Gly Ser Gly Asp Gly Met Ile Lys Val Lys Asn 
    450                 455                 460                 


Gln Leu Arg Phe Leu Ala Glu Leu Ala Tyr Asp Leu Asp Val Asp Asp 
465                 470                 475                 480 


Ala Pro Gly Asn Ser Gln Gln Ala Thr Pro Lys Asp Asn Glu Ile Ser 
                485                 490                 495     


Thr Phe His Asn Leu Gly Asn Val His Ser Pro Leu Lys Leu Leu Thr 
            500                 505                 510         


Ser Met Ala Ile Ser Val Val Cys Phe Phe Phe Leu Val His 
        515                 520                 525     


<210>  2092
<211>  1950
<212>  PRT
<213>  Homo sapiens

<400>  2092

Met Pro Gly Ala Arg Arg Arg Arg Arg Gly Ala Ala Met Glu Gly Lys 
1               5                   10                  15      


Pro Arg Ala Gly Val Ala Leu Ala Pro Gly Pro Ser Gly Arg Arg Pro 
            20                  25                  30          


Ser Ala Arg Cys Ala Arg Arg Arg Arg Pro Gly Leu Leu Leu Pro Gly 
        35                  40                  45              


Leu Trp Leu Leu Leu Leu Ala Arg Pro Ala Ser Cys Ala Pro Asp Glu 
    50                  55                  60                  


Leu Ser Pro Glu Gln His Asn Leu Ser Leu Tyr Ser Met Glu Leu Val 
65                  70                  75                  80  


Leu Lys Lys Ser Thr Gly His Ser Ala Ala Gln Val Ala Leu Thr Glu 
                85                  90                  95      


Thr Ala Pro Gly Ser Gln His Ser Ser Pro Leu His Val Thr Ala Pro 
            100                 105                 110         


Pro Ser Ala Thr Thr Phe Asp Thr Ala Phe Phe Asn Gln Gly Lys Gln 
        115                 120                 125             


Thr Lys Ser Thr Ala Asp Pro Ser Ile Phe Val Ala Thr Tyr Val Ser 
    130                 135                 140                 


Val Thr Ser Lys Glu Val Ala Val Asn Asp Asp Glu Met Asp Asn Phe 
145                 150                 155                 160 


Leu Pro Asp Thr His Trp Thr Thr Pro Arg Met Val Ser Pro Ile Gln 
                165                 170                 175     


Tyr Ile Thr Val Ser Pro Pro Gly Leu Pro Arg Glu Ala Leu Glu Pro 
            180                 185                 190         


Met Leu Thr Pro Ser Leu Pro Met Val Ser Leu Gln Asp Glu Glu Val 
        195                 200                 205             


Thr Ser Gly Trp Gln Asn Thr Thr Arg Gln Pro Ala Ala Tyr Ala Glu 
    210                 215                 220                 


Ser Ala Ser His Phe His Thr Phe Arg Ser Ala Phe Arg Thr Ser Glu 
225                 230                 235                 240 


Gly Ile Val Pro Thr Pro Gly Arg Asn Leu Val Leu Tyr Pro Thr Asp 
                245                 250                 255     


Ala Tyr Ser His Leu Ser Ser Arg Thr Leu Pro Glu Ile Val Ala Ser 
            260                 265                 270         


Leu Thr Glu Gly Val Glu Thr Thr Leu Phe Leu Ser Ser Arg Ser Leu 
        275                 280                 285             


Met Pro Gln Pro Leu Gly Asp Gly Ile Thr Ile Pro Leu Pro Ser Leu 
    290                 295                 300                 


Gly Glu Val Ser Gln Pro Pro Glu Glu Val Trp Ala Thr Ser Ala Asp 
305                 310                 315                 320 


Arg Tyr Thr Asp Val Thr Thr Val Leu Ser Gln Ser Leu Glu Glu Thr 
                325                 330                 335     


Ile Ser Pro Arg Thr Tyr Pro Thr Val Thr Ala Ser His Ala Ala Leu 
            340                 345                 350         


Ala Phe Ser Arg Thr His Ser Pro Leu Leu Ser Thr Pro Leu Ala Phe 
        355                 360                 365             


Ala Ser Ser Ala Ser Pro Thr Asp Val Ser Ser Asn Pro Phe Leu Pro 
    370                 375                 380                 


Ser Asp Ser Ser Lys Thr Ser Glu Leu His Ser Asn Ser Ala Leu Pro 
385                 390                 395                 400 


Gly Pro Val Asp Asn Thr His Ile Leu Ser Pro Val Ser Ser Phe Arg 
                405                 410                 415     


Pro Tyr Thr Trp Cys Ala Ala Cys Thr Val Pro Ser Pro Gln Gln Val 
            420                 425                 430         


Leu Ala Thr Ser Leu Met Glu Lys Asp Val Gly Ser Gly Asp Gly Ala 
        435                 440                 445             


Glu Thr Leu Cys Met Thr Val Leu Glu Glu Ser Ser Ile Ser Leu Met 
    450                 455                 460                 


Ser Ser Val Val Ala Asp Phe Ser Glu Phe Glu Glu Asp Pro Gln Val 
465                 470                 475                 480 


Phe Asn Thr Leu Phe Pro Ser Arg Pro Ile Val Pro Leu Ser Ser Arg 
                485                 490                 495     


Ser Met Glu Ile Ser Glu Thr Ser Val Gly Ile Ser Ala Glu Val Asp 
            500                 505                 510         


Met Ser Ser Val Thr Thr Thr Gln Val Pro Pro Ala His Gly Arg Leu 
        515                 520                 525             


Ser Val Pro Ala Ser Leu Asp Pro Thr Ala Gly Ser Leu Ser Val Ala 
    530                 535                 540                 


Glu Thr Gln Val Thr Pro Ser Ser Val Thr Thr Ala Phe Phe Ser Val 
545                 550                 555                 560 


Ile Thr Ser Ile Leu Leu Asp Ser Ser Phe Ser Val Ile Ala Asn Lys 
                565                 570                 575     


Asn Thr Pro Ser Leu Ala Val Arg Asp Pro Ser Val Phe Thr Pro Tyr 
            580                 585                 590         


Ser Leu Val Pro Ser Val Glu Ser Ser Leu Phe Ser Asp Gln Glu Arg 
        595                 600                 605             


Ser Ser Phe Ser Glu His Lys Pro Arg Gly Ala Leu Asp Phe Ala Ser 
    610                 615                 620                 


Ser Phe Phe Ser Thr Pro Pro Leu Glu Leu Ser Gly Ser Ile Ser Ser 
625                 630                 635                 640 


Pro Ser Glu Ala Pro Ala Ser Leu Ser Leu Met Pro Ser Asp Leu Ser 
                645                 650                 655     


Pro Phe Thr Ser Gln Ser Phe Ser Pro Leu Val Glu Thr Phe Thr Leu 
            660                 665                 670         


Phe Asp Ser Ser Asp Leu Gln Ser Ser Gln Leu Ser Leu Pro Ser Ser 
        675                 680                 685             


Thr Asn Leu Glu Phe Ser Gln Leu Gln Pro Ser Ser Glu Leu Pro Leu 
    690                 695                 700                 


Asn Thr Ile Met Leu Leu Pro Ser Arg Ser Glu Val Ser Pro Trp Ser 
705                 710                 715                 720 


Ser Phe Pro Ser Asp Ser Leu Glu Phe Val Glu Ala Ser Thr Val Ser 
                725                 730                 735     


Leu Thr Asp Ser Glu Ala His Phe Thr Ser Ala Phe Ile Glu Thr Thr 
            740                 745                 750         


Ser Tyr Leu Glu Ser Ser Leu Ile Ser His Glu Ser Ala Val Thr Ala 
        755                 760                 765             


Leu Val Pro Pro Gly Ser Glu Ser Phe Asp Ile Leu Thr Ala Gly Ile 
    770                 775                 780                 


Gln Ala Thr Ser Pro Leu Thr Thr Val His Thr Thr Pro Ile Leu Thr 
785                 790                 795                 800 


Glu Ser Ser Leu Phe Ser Thr Leu Thr Pro Pro Asp Asp Gln Ile Ser 
                805                 810                 815     


Ala Leu Asp Gly His Val Ser Val Leu Ala Ser Phe Ser Lys Ala Ile 
            820                 825                 830         


Pro Thr Gly Thr Val Leu Ile Thr Asp Ala Tyr Leu Pro Ser Gly Ser 
        835                 840                 845             


Ser Phe Val Ser Glu Ala Thr Pro Phe Pro Leu Pro Thr Glu Leu Thr 
    850                 855                 860                 


Val Val Gly Pro Ser Leu Thr Pro Thr Glu Val Pro Leu Asn Thr Ser 
865                 870                 875                 880 


Thr Glu Val Ser Thr Thr Ser Thr Gly Ala Ala Thr Gly Gly Pro Leu 
                885                 890                 895     


Asp Ser Thr Leu Met Gly Asp Ala Ala Ser Gln Ser Pro Pro Glu Ser 
            900                 905                 910         


Ser Ala Ala Pro Pro Leu Pro Ser Leu Arg Pro Val Thr Ala Phe Thr 
        915                 920                 925             


Leu Glu Ala Thr Val Asp Thr Pro Thr Leu Ala Thr Ala Lys Pro Pro 
    930                 935                 940                 


Tyr Val Cys Asp Ile Thr Val Pro Asp Ala Tyr Leu Ile Thr Thr Val 
945                 950                 955                 960 


Leu Ala Arg Arg Ala Val Gln Glu Tyr Ile Ile Thr Ala Ile Lys Glu 
                965                 970                 975     


Val Leu Arg Ile His Phe Asn Arg Ala Val Glu Leu Lys Val Tyr Glu 
            980                 985                 990         


Leu Phe Thr Asp Phe Thr Phe Leu  Val Thr Ser Gly Pro  Phe Val Tyr 
        995                 1000                 1005             


Thr Ala  Ile Ser Val Ile Asn  Val Leu Ile Asn Ser  Lys Leu Val 
    1010                 1015                 1020             


Arg Asp  Gln Thr Pro Leu Ile  Leu Ser Val Lys Pro  Ser Phe Leu 
    1025                 1030                 1035             


Val Pro  Glu Ser Arg Phe Gln  Val Gln Thr Val Leu  Gln Phe Val 
    1040                 1045                 1050             


Pro Pro  Ser Val Asp Thr Gly  Phe Cys Asn Phe Thr  Gln Arg Ile 
    1055                 1060                 1065             


Glu Lys  Gly Leu Met Thr Ala  Leu Phe Glu Val Arg  Lys His His 
    1070                 1075                 1080             


Gln Gly  Thr Tyr Asn Leu Thr  Val Gln Ile Leu Asn  Ile Thr Ile 
    1085                 1090                 1095             


Ser Ser  Ser Arg Val Thr Pro  Arg Arg Gly Pro Val  Asn Ile Ile 
    1100                 1105                 1110             


Phe Ala  Val Lys Ser Thr Gln  Gly Phe Leu Asn Gly  Ser Glu Val 
    1115                 1120                 1125             


Ser Glu  Leu Leu Arg Asn Leu  Ser Val Val Glu Phe  Ser Phe Tyr 
    1130                 1135                 1140             


Leu Gly  Tyr Pro Val Leu Gln  Ile Ala Glu Pro Phe  Gln Tyr Pro 
    1145                 1150                 1155             


Gln Leu  Asn Leu Ser Gln Leu  Leu Lys Ser Ser Trp  Val Arg Thr 
    1160                 1165                 1170             


Val Leu  Leu Gly Val Met Glu  Lys Gln Leu Gln Asn  Glu Val Phe 
    1175                 1180                 1185             


Gln Ala  Glu Met Glu Arg Lys  Leu Ala Gln Leu Leu  Ser Glu Val 
    1190                 1195                 1200             


Ser Thr  Arg Arg Arg Met Trp  Arg Arg Ala Thr Val  Ala Ala Gly 
    1205                 1210                 1215             


Asn Ser  Val Val Gln Val Val  Asn Val Ser Arg Leu  Glu Gly Asp 
    1220                 1225                 1230             


Asp Asn  Pro Val Gln Leu Ile  Tyr Phe Val Glu Asp  Gln Asp Gly 
    1235                 1240                 1245             


Glu Arg  Leu Ser Ala Val Lys  Ser Ser Asp Leu Ile  Asn Lys Met 
    1250                 1255                 1260             


Asp Leu  Gln Arg Ala Ala Ile  Ile Leu Gly Tyr Arg  Ile Gln Gly 
    1265                 1270                 1275             


Val Ile  Ala Gln Pro Val Asp  Arg Val Lys Arg Pro  Ser Pro Glu 
    1280                 1285                 1290             


Ser Gln  Ser Asn Asn Leu Trp  Val Ile Val Gly Val  Val Ile Pro 
    1295                 1300                 1305             


Val Leu  Val Val Met Val Ile  Val Val Ile Leu Tyr  Trp Lys Leu 
    1310                 1315                 1320             


Cys Arg  Thr Asp Lys Leu Asp  Phe Gln Pro Asp Thr  Val Ala Asn 
    1325                 1330                 1335             


Ile Gln  Gln Arg Gln Lys Leu  Gln Ile Pro Ser Val  Lys Gly Phe 
    1340                 1345                 1350             


Asp Phe  Ala Lys Gln His Leu  Gly Gln His Asn Lys  Asp Asp Ile 
    1355                 1360                 1365             


Leu Ile  Ile His Glu Pro Ala  Pro Leu Pro Gly Pro  Leu Lys Asp 
    1370                 1375                 1380             


His Thr  Thr Pro Ser Glu Asn  Gly Asp Val Pro Ser  Pro Lys Ser 
    1385                 1390                 1395             


Lys Ile  Pro Ser Lys Asn Val  Arg His Arg Gly Arg  Val Ser Pro 
    1400                 1405                 1410             


Ser Asp  Ala Asp Ser Thr Val  Ser Glu Glu Ser Ser  Glu Arg Asp 
    1415                 1420                 1425             


Ala Gly  Asp Lys Thr Pro Gly  Ala Val Asn Asp Gly  Arg Ser His 
    1430                 1435                 1440             


Arg Ala  Pro Gln Ser Gly Pro  Pro Leu Pro Ser Ser  Gly Asn Glu 
    1445                 1450                 1455             


Gln His  Ser Ser Ala Ser Ile  Phe Glu His Val Asp  Arg Ile Ser 
    1460                 1465                 1470             


Arg Pro  Pro Glu Ala Ser Arg  Arg Val Pro Ser Lys  Ile Gln Leu 
    1475                 1480                 1485             


Ile Ala  Met Gln Pro Ile Pro  Ala Pro Pro Val Gln  Arg Pro Ser 
    1490                 1495                 1500             


Pro Ala  Asp Arg Val Ala Glu  Ser Asn Lys Ile Asn  Lys Glu Ile 
    1505                 1510                 1515             


Gln Thr  Ala Leu Arg His Lys  Ser Glu Ile Glu His  His Arg Asn 
    1520                 1525                 1530             


Lys Ile  Arg Leu Arg Ala Lys  Arg Arg Gly His Tyr  Glu Phe Pro 
    1535                 1540                 1545             


Val Val  Asp Asp Leu Ser Ser  Gly Asp Thr Lys Glu  Arg His Arg 
    1550                 1555                 1560             


Val Tyr  Arg Arg Ala Gln Met  Gln Ile Asp Lys Ile  Leu Asp Pro 
    1565                 1570                 1575             


Thr Ala  Ser Val Pro Ser Val  Phe Ile Glu Pro Arg  Lys Ser Ser 
    1580                 1585                 1590             


Arg Ile  Lys Arg Ser Pro Lys  Pro Arg Arg Lys His  Gln Val Asn 
    1595                 1600                 1605             


Gly Cys  Pro Ala Asp Ala Glu  Lys Asp Arg Leu Ile  Thr Thr Asp 
    1610                 1615                 1620             


Ser Asp  Gly Thr Tyr Arg Arg  Pro Pro Gly Val His  Asn Ser Ala 
    1625                 1630                 1635             


Tyr Ile  Gly Cys Pro Ser Asp  Pro Asp Leu Pro Ala  Asp Val Gln 
    1640                 1645                 1650             


Thr Pro  Ser Ser Val Glu Leu  Gly Arg Tyr Pro Ala  Leu Pro Phe 
    1655                 1660                 1665             


Pro Ala  Ser Gln Tyr Ile Pro  Pro Gln Pro Ser Ile  Glu Glu Ala 
    1670                 1675                 1680             


Arg Gln  Thr Met His Ser Leu  Leu Asp Asp Ala Phe  Ala Leu Val 
    1685                 1690                 1695             


Ala Pro  Ser Ser Gln Pro Ala  Ser Thr Ala Gly Val  Gly Pro Gly 
    1700                 1705                 1710             


Val Pro  Pro Gly Leu Pro Ala  Asn Ser Thr Pro Ser  Gln Glu Glu 
    1715                 1720                 1725             


Arg Arg  Ala Thr Gln Trp Gly  Ser Phe Tyr Ser Pro  Ala Gln Thr 
    1730                 1735                 1740             


Ala Asn  Asn Pro Cys Ser Arg  Tyr Glu Asp Tyr Gly  Met Thr Pro 
    1745                 1750                 1755             


Pro Thr  Gly Pro Leu Pro Arg  Pro Gly Phe Gly Pro  Gly Leu Leu 
    1760                 1765                 1770             


Gln Ser  Thr Glu Leu Val Pro  Pro Asp Pro Gln Gln  Pro Gln Ala 
    1775                 1780                 1785             


Ser Ala  Glu Ala Pro Phe Ala  Ala Arg Gly Ile Tyr  Ser Glu Glu 
    1790                 1795                 1800             


Met Pro  Ser Val Ala Arg Pro  Arg Pro Val Gly Gly  Thr Thr Gly 
    1805                 1810                 1815             


Ser Gln  Ile Gln His Leu Thr  Gln Val Gly Ile Ala  Ser Arg Ile 
    1820                 1825                 1830             


Gly Ala  Gln Pro Val Glu Ile  Pro Pro Ser Arg Gly  Ser Gln Tyr 
    1835                 1840                 1845             


Gly Gly  Pro Gly Trp Pro Ser  Tyr Gly Glu Asp Glu  Ala Gly Arg 
    1850                 1855                 1860             


Arg Glu  Ala Thr His Met Leu  Gly His Gln Glu Tyr  Ser Ser Ser 
    1865                 1870                 1875             


Pro Leu  Phe Gln Val Pro Arg  Thr Ser Gly Arg Glu  Pro Ser Ala 
    1880                 1885                 1890             


Pro Ser  Gly Asn Leu Pro His  Arg Gly Leu Gln Gly  Pro Gly Leu 
    1895                 1900                 1905             


Gly Tyr  Pro Thr Ser Ser Thr  Glu Asp Leu Gln Pro  Gly His Ser 
    1910                 1915                 1920             


Ser Ala  Ser Leu Ile Lys Ala  Ile Arg Glu Glu Leu  Leu Arg Leu 
    1925                 1930                 1935             


Ser Gln  Lys Gln Ser Thr Val  Gln Asn Phe His Ser  
    1940                 1945                 1950 


<210>  2093
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  2093

Met Pro Phe Gly Ile Arg Met Leu Leu Arg Ala His Lys Pro Gly Arg 
1               5                   10                  15      


Ser Glu Met Thr Thr Ser Leu Asp Thr Val Glu Thr Phe Gly Thr Thr 
            20                  25                  30          


Ser Tyr Tyr Asp Asp Val Gly Leu Leu Cys Glu Lys Ala Asp Thr Arg 
        35                  40                  45              


Ala Leu Met Ala Gln Phe Val Pro Pro Leu Tyr Ser Leu Val Phe Thr 
    50                  55                  60                  


Val Gly Leu Leu Gly Asn Val Val Val Val Met Ile Leu Ile Lys Tyr 
65                  70                  75                  80  


Arg Arg Leu Arg Ile Met Thr Asn Ile Tyr Leu Leu Asn Leu Ala Ile 
                85                  90                  95      


Ser Asp Leu Leu Phe Leu Val Thr Leu Pro Phe Trp Ile His Tyr Val 
            100                 105                 110         


Arg Gly His Asn Trp Val Phe Gly His Gly Met Cys Lys Leu Leu Ser 
        115                 120                 125             


Gly Phe Tyr His Thr Gly Leu Tyr Ser Glu Ile Phe Phe Ile Ile Leu 
    130                 135                 140                 


Leu Thr Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe Ala Leu 
145                 150                 155                 160 


Arg Ala Arg Thr Val Thr Phe Gly Val Ile Thr Ser Ile Val Thr Trp 
                165                 170                 175     


Gly Leu Ala Val Leu Ala Ala Leu Pro Glu Phe Ile Phe Tyr Glu Thr 
            180                 185                 190         


Glu Glu Leu Phe Glu Glu Thr Leu Cys Ser Ala Leu Tyr Pro Glu Asp 
        195                 200                 205             


Thr Val Tyr Ser Trp Arg His Phe His Thr Leu Arg Met Thr Ile Phe 
    210                 215                 220                 


Cys Leu Val Leu Pro Leu Leu Val Met Ala Ile Cys Tyr Thr Gly Ile 
225                 230                 235                 240 


Ile Lys Thr Leu Leu Arg Cys Pro Ser Lys Lys Lys Tyr Lys Ala Ile 
                245                 250                 255     


Arg Leu Ile Phe Val Ile Met Ala Val Phe Phe Ile Phe Trp Thr Pro 
            260                 265                 270         


Tyr Asn Val Ala Ile Leu Leu Ser Ser Tyr Gln Ser Ile Leu Phe Gly 
        275                 280                 285             


Asn Asp Cys Glu Arg Ser Lys His Leu Asp Leu Val Met Leu Val Thr 
    290                 295                 300                 


Glu Val Ile Ala Tyr Ser His Cys Cys Met Asn Pro Val Ile Tyr Ala 
305                 310                 315                 320 


Phe Val Gly Glu Arg Phe Arg Lys Tyr Leu Arg His Phe Phe His Arg 
                325                 330                 335     


His Leu Leu Met His Leu Gly Arg Tyr Ile Pro Phe Leu Pro Ser Glu 
            340                 345                 350         


Lys Leu Glu Arg Thr Ser Ser Val Ser Pro Ser Thr Ala Glu Pro Glu 
        355                 360                 365             


Leu Ser Ile Val Phe 
    370             


<210>  2094
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  2094

Met Leu Gly Ser Leu Gly Leu Trp Ala Leu Leu Pro Thr Ala Val Glu 
1               5                   10                  15      


Ala Pro Pro Asn Arg Arg Thr Cys Val Phe Phe Glu Ala Pro Gly Val 
            20                  25                  30          


Arg Gly Ser Thr Lys Thr Leu Gly Glu Leu Leu Asp Thr Gly Thr Glu 
        35                  40                  45              


Leu Pro Arg Ala Ile Arg Cys Leu Tyr Ser Arg Cys Cys Phe Gly Ile 
    50                  55                  60                  


Trp Asn Leu Thr Gln Asp Arg Ala Gln Val Glu Met Gln Gly Cys Arg 
65                  70                  75                  80  


Asp Ser Asp Glu Pro Gly Cys Glu Ser Leu His Cys Asp Pro Ser Pro 
                85                  90                  95      


Arg Ala His Pro Ser Pro Gly Ser Thr Leu Phe Thr Cys Ser Cys Gly 
            100                 105                 110         


Thr Asp Phe Cys Asn Ala Asn Tyr Ser His Leu Pro Pro Pro Gly Ser 
        115                 120                 125             


Pro Gly Thr Pro Gly Ser Gln Gly Pro Gln Ala Ala Pro Gly Glu Ser 
    130                 135                 140                 


Ile Trp Met Ala Leu Val Leu Leu Gly Leu Phe Leu Leu Leu Leu Leu 
145                 150                 155                 160 


Leu Leu Gly Ser Ile Ile Leu Ala Leu Leu Gln Arg Lys Asn Tyr Arg 
                165                 170                 175     


Val Arg Gly Glu Pro Val Pro Glu Pro Arg Pro Asp Ser Gly Arg Asp 
            180                 185                 190         


Trp Ser Val Glu Leu Gln Glu Leu Pro Glu Leu Cys Phe Ser Gln Val 
        195                 200                 205             


Ile Arg Glu Gly Gly His Ala Val Val Trp Ala Gly Gln Leu Gln Gly 
    210                 215                 220                 


Lys Leu Val Ala Ile Lys Ala Phe Pro Pro Arg Ser Val Ala Gln Phe 
225                 230                 235                 240 


Gln Ala Glu Arg Ala Leu Tyr Glu Leu Pro Gly Leu Gln His Asp His 
                245                 250                 255     


Ile Val Arg Phe Ile Thr Ala Ser Arg Gly Gly Pro Gly Arg Leu Leu 
            260                 265                 270         


Ser Gly Pro Leu Leu Val Leu Glu Leu His Pro Lys Gly Ser Leu Cys 
        275                 280                 285             


His Tyr Leu Thr Gln Tyr Thr Ser Asp Trp Gly Ser Ser Leu Arg Met 
    290                 295                 300                 


Ala Leu Ser Leu Ala Gln Gly Leu Ala Phe Leu His Glu Glu Arg Trp 
305                 310                 315                 320 


Gln Asn Gly Gln Tyr Lys Pro Gly Ile Ala His Arg Asp Leu Ser Ser 
                325                 330                 335     


Gln Asn Val Leu Ile Arg Glu Asp Gly Ser Cys Ala Ile Gly Asp Leu 
            340                 345                 350         


Gly Leu Ala Leu Val Leu Pro Gly Leu Thr Gln Pro Pro Ala Trp Thr 
        355                 360                 365             


Pro Thr Gln Pro Gln Gly Pro Ala Ala Ile Met Glu Ala Gly Thr Gln 
    370                 375                 380                 


Arg Tyr Met Ala Pro Glu Leu Leu Asp Lys Thr Leu Asp Leu Gln Asp 
385                 390                 395                 400 


Trp Gly Met Ala Leu Arg Arg Ala Asp Ile Tyr Ser Leu Ala Leu Leu 
                405                 410                 415     


Leu Trp Glu Ile Leu Ser Arg Cys Pro Asp Leu Arg Pro Ala Val His 
            420                 425                 430         


His Pro Ser Asn Trp Pro Met Arg Gln Asn Trp Ala Ile Pro Leu Pro 
        435                 440                 445             


Leu Met Ser Tyr Gly Pro Trp Gln Cys Arg Arg Gly Gly Val Pro Thr 
    450                 455                 460                 


Ser His Pro Pro Gly Ala Ala Leu Pro Gln Thr Leu Met Gly 
465                 470                 475             


<210>  2095
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  2095

Met Leu Gly Ser Leu Gly Leu Trp Ala Leu Leu Pro Thr Ala Val Glu 
1               5                   10                  15      


Ala Pro Pro Asn Arg Arg Thr Cys Val Phe Phe Glu Ala Pro Gly Val 
            20                  25                  30          


Arg Gly Ser Thr Lys Thr Leu Gly Glu Leu Leu Asp Thr Gly Thr Glu 
        35                  40                  45              


Leu Pro Arg Ala Ile Arg Cys Leu Tyr Ser Arg Cys Cys Phe Gly Ile 
    50                  55                  60                  


Trp Asn Leu Thr Gln Asp Arg Ala Gln Val Glu Met Gln Gly Cys Arg 
65                  70                  75                  80  


Asp Ser Asp Glu Pro Gly Cys Glu Ser Leu His Cys Asp Pro Ser Pro 
                85                  90                  95      


Arg Ala His Pro Ser Pro Gly Ser Thr Leu Phe Thr Cys Ser Cys Gly 
            100                 105                 110         


Thr Asp Phe Cys Asn Ala Asn Tyr Ser His Leu Pro Pro Pro Gly Ser 
        115                 120                 125             


Pro Gly Thr Pro Gly Ser Gln Gly Pro Gln Ala Ala Pro Gly Glu Ser 
    130                 135                 140                 


Ile Trp Met Ala Leu Val Leu Leu Gly Leu Phe Leu Leu Leu Leu Leu 
145                 150                 155                 160 


Leu Leu Gly Ser Ile Ile Leu Ala Leu Leu Gln Arg Lys Asn Tyr Arg 
                165                 170                 175     


Val Arg Gly Glu Pro Val Pro Glu Pro Arg Pro Asp Ser Gly Arg Asp 
            180                 185                 190         


Trp Ser Val Glu Leu Gln Glu Leu Pro Glu Leu Cys Phe Ser Gln Val 
        195                 200                 205             


Ile Arg Glu Gly Gly His Ala Val Val Trp Ala Gly Gln Leu Gln Gly 
    210                 215                 220                 


Lys Leu Val Ala Ile Lys Ala Phe Pro Pro Arg Ser Val Ala Gln Phe 
225                 230                 235                 240 


Gln Ala Glu Arg Ala Leu Tyr Glu Leu Pro Gly Leu Gln His Asp His 
                245                 250                 255     


Ile Val Arg Phe Ile Thr Ala Ser Arg Gly Gly Pro Gly Arg Leu Leu 
            260                 265                 270         


Ser Gly Pro Leu Leu Val Leu Glu Leu His Pro Lys Gly Ser Leu Cys 
        275                 280                 285             


His Tyr Leu Thr Gln Tyr Thr Ser Asp Trp Gly Ser Ser Leu Arg Met 
    290                 295                 300                 


Ala Leu Ser Leu Ala Gln Gly Leu Ala Phe Leu His Glu Glu Arg Trp 
305                 310                 315                 320 


Gln Asn Gly Gln Tyr Lys Pro Gly Ile Ala His Arg Asp Leu Ser Ser 
                325                 330                 335     


Gln Asn Val Leu Ile Arg Glu Asp Gly Ser Cys Ala Ile Gly Asp Leu 
            340                 345                 350         


Gly Leu Ala Leu Val Leu Pro Gly Leu Thr Gln Pro Pro Ala Trp Thr 
        355                 360                 365             


Pro Thr Gln Pro Gln Gly Pro Ala Ala Ile Met Glu Asp Pro Asp Gly 
    370                 375                 380                 


Leu Arg Glu Leu Leu Glu Asp Cys Trp Asp Ala Asp Pro Glu Ala Arg 
385                 390                 395                 400 


Leu Thr Ala Glu Cys Val Gln Gln Arg Leu Ala Ala Leu Ala His Pro 
                405                 410                 415     


Gln Glu Ser His Pro Phe Pro Glu Ser Cys Pro Arg Gly Cys Pro Pro 
            420                 425                 430         


Leu Cys Pro Glu Asp Cys Thr Ser Ile Pro Ala Pro Thr Ile Leu Pro 
        435                 440                 445             


Cys Arg Pro Gln Arg Ser Ala Cys His Phe Ser Val Gln Gln Gly Pro 
    450                 455                 460                 


Cys Ser Arg Asn Pro Gln Pro Ala Cys Thr Leu Ser Pro Val 
465                 470                 475             


<210>  2096
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  2096

Met Ser Val Cys Tyr Arg Pro Pro Gly Asn Glu Thr Leu Leu Ser Trp 
1               5                   10                  15      


Lys Thr Ser Arg Ala Thr Gly Thr Ala Phe Leu Leu Leu Ala Ala Leu 
            20                  25                  30          


Leu Gly Leu Pro Gly Asn Gly Phe Val Val Trp Ser Leu Ala Gly Trp 
        35                  40                  45              


Arg Pro Ala Arg Gly Arg Pro Leu Ala Ala Thr Leu Val Leu His Leu 
    50                  55                  60                  


Ala Leu Ala Asp Gly Ala Val Leu Leu Leu Thr Pro Leu Phe Val Ala 
65                  70                  75                  80  


Phe Leu Thr Arg Gln Ala Trp Pro Leu Gly Gln Ala Gly Cys Lys Ala 
                85                  90                  95      


Val Tyr Tyr Val Cys Ala Leu Ser Met Tyr Ala Ser Val Leu Leu Thr 
            100                 105                 110         


Gly Leu Leu Ser Leu Gln Arg Cys Leu Ala Val Thr Arg Pro Phe Leu 
        115                 120                 125             


Ala Pro Arg Leu Arg Ser Pro Ala Leu Ala Arg Arg Leu Leu Leu Ala 
    130                 135                 140                 


Val Trp Leu Ala Ala Leu Leu Leu Ala Val Pro Ala Ala Val Tyr Arg 
145                 150                 155                 160 


His Leu Trp Arg Asp Arg Val Cys Gln Leu Cys His Pro Ser Pro Val 
                165                 170                 175     


His Ala Ala Ala His Leu Ser Leu Glu Thr Leu Thr Ala Phe Val Leu 
            180                 185                 190         


Pro Phe Gly Leu Met Leu Gly Cys Tyr Ser Val Thr Leu Ala Arg Leu 
        195                 200                 205             


Arg Gly Ala Arg Trp Gly Ser Gly Arg His Gly Ala Arg Val Gly Arg 
    210                 215                 220                 


Leu Val Ser Ala Ile Val Leu Ala Phe Gly Leu Leu Trp Ala Pro Tyr 
225                 230                 235                 240 


His Ala Val Asn Leu Leu Gln Ala Val Ala Ala Leu Ala Pro Pro Glu 
                245                 250                 255     


Gly Ala Leu Ala Lys Leu Gly Gly Ala Gly Gln Ala Ala Arg Ala Gly 
            260                 265                 270         


Thr Thr Ala Leu Ala Phe Phe Ser Ser Ser Val Asn Pro Val Leu Tyr 
        275                 280                 285             


Val Phe Thr Ala Gly Asp Leu Leu Pro Arg Ala Gly Pro Arg Phe Leu 
    290                 295                 300                 


Thr Arg Leu Phe Glu Gly Ser Gly Glu Ala Arg Gly Gly Gly Arg Ser 
305                 310                 315                 320 


Arg Glu Gly Thr Met Glu Leu Arg Thr Thr Pro Gln Leu Lys Val Val 
                325                 330                 335     


Gly Gln Gly Arg Gly Asn Gly Asp Pro Gly Gly Gly Met Glu Lys Asp 
            340                 345                 350         


Gly Pro Glu Trp Asp Leu 
        355             


<210>  2097
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  2097

Met Ser Val Cys Tyr Arg Pro Pro Gly Asn Glu Thr Leu Leu Ser Trp 
1               5                   10                  15      


Lys Thr Ser Arg Ala Thr Gly Thr Ala Phe Leu Leu Leu Ala Ala Leu 
            20                  25                  30          


Leu Gly Leu Pro Gly Asn Gly Phe Val Val Trp Ser Leu Ala Gly Trp 
        35                  40                  45              


Arg Pro Ala Arg Gly Arg Pro Leu Ala Ala Thr Leu Val Leu His Leu 
    50                  55                  60                  


Ala Leu Ala Asp Gly Ala Val Leu Leu Leu Thr Pro Leu Phe Val Ala 
65                  70                  75                  80  


Phe Leu Thr Arg Gln Ala Trp Pro Leu Gly Gln Ala Gly Cys Lys Ala 
                85                  90                  95      


Val Tyr Tyr Val Cys Ala Leu Ser Met Tyr Ala Ser Val Leu Leu Thr 
            100                 105                 110         


Gly Leu Leu Ser Leu Gln Arg Cys Leu Ala Val Thr Arg Pro Phe Leu 
        115                 120                 125             


Ala Pro Arg Leu Arg Ser Pro Ala Leu Ala Arg Arg Leu Leu Leu Ala 
    130                 135                 140                 


Val Trp Leu Ala Ala Leu Leu Leu Ala Val Pro Ala Ala Val Tyr Arg 
145                 150                 155                 160 


His Leu Trp Arg Asp Arg Val Cys Gln Leu Cys His Pro Ser Pro Val 
                165                 170                 175     


His Ala Ala Ala His Leu Ser Leu Glu Thr Leu Thr Ala Phe Val Leu 
            180                 185                 190         


Pro Phe Gly Leu Met Leu Gly Cys Tyr Ser Val Thr Leu Ala Arg Leu 
        195                 200                 205             


Arg Gly Ala Arg Trp Gly Ser Gly Arg His Gly Ala Arg Val Gly Arg 
    210                 215                 220                 


Leu Val Ser Ala Ile Val Leu Ala Phe Gly Leu Leu Trp Ala Pro Tyr 
225                 230                 235                 240 


His Ala Val Asn Leu Leu Gln Ala Val Ala Ala Leu Ala Pro Pro Glu 
                245                 250                 255     


Gly Ala Leu Ala Lys Leu Gly Gly Ala Gly Gln Ala Ala Arg Ala Gly 
            260                 265                 270         


Thr Thr Ala Leu Ala Phe Phe Ser Ser Ser Val Asn Pro Val Leu Tyr 
        275                 280                 285             


Val Phe Thr Ala Gly Asp Leu Leu Pro Arg Ala Gly Pro Arg Phe Leu 
    290                 295                 300                 


Thr Arg Leu Phe Glu Gly Ser Gly Glu Ala Arg Gly Gly Gly Arg Ser 
305                 310                 315                 320 


Arg Glu Gly Thr Met Glu Leu Arg Thr Thr Pro Gln Leu Lys Val Val 
                325                 330                 335     


Gly Gln Gly Arg Gly Asn Gly Asp Pro Gly Gly Gly Met Glu Lys Asp 
            340                 345                 350         


Gly Pro Glu Trp Asp Leu 
        355             


<210>  2098
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  2098

Met Tyr Phe Leu Thr Pro Ile Leu Val Ala Ile Leu Cys Ile Leu Val 
1               5                   10                  15      


Val Trp Ile Phe Lys Asn Ala Asp Arg Ser Met Glu Lys Lys Lys Gly 
            20                  25                  30          


Glu Pro Arg Thr Arg Ala Glu Ala Arg Pro Trp Val Asp Glu Asp Leu 
        35                  40                  45              


Lys Asp Ser Ser Asp Leu His Gln Ala Glu Glu Asp Ala Asp Glu Trp 
    50                  55                  60                  


Gln Glu Ser Glu Glu Asn Val Glu His Ile Pro Phe Ser His Asn His 
65                  70                  75                  80  


Tyr Pro Glu Lys Glu Met Val Lys Arg Ser Gln Glu Phe Tyr Glu Leu 
                85                  90                  95      


Leu Asn Lys Arg Arg Ser Val Arg Phe Ile Ser Asn Glu Gln Val Pro 
            100                 105                 110         


Met Glu Val Ile Asp Asn Val Ile Arg Thr Ala Gly Thr Ala Pro Ser 
        115                 120                 125             


Gly Ala His Thr Glu Pro Trp Thr Phe Val Val Val Lys Asp Pro Asp 
    130                 135                 140                 


Val Lys His Lys Ile Arg Lys Ile Ile Glu Glu Glu Glu Glu Ile Asn 
145                 150                 155                 160 


Tyr Met Lys Arg Met Gly His Arg Trp Val Thr Asp Leu Lys Lys Leu 
                165                 170                 175     


Arg Thr Asn Trp Ile Lys Glu Tyr Leu Asp Thr Ala Pro Ile Leu Ile 
            180                 185                 190         


Leu Ile Phe Lys Gln Val His Gly Phe Ala Ala Asn Gly Lys Lys Lys 
        195                 200                 205             


Val His Tyr Tyr Asn Glu Ile Ser Val Ser Ile Ala Cys Gly Ile Leu 
    210                 215                 220                 


Leu Ala Ala Leu Gln Val Asn Asn Gly Ile Thr Met Arg His Gln Thr 
225                 230                 235                 240 


Ala Arg His Arg His Leu Ile Glu Gly Pro Gly Arg Ser Ser Glu Ala 
                245                 250                 255     


Cys Ser Lys Leu Ser Ser Gln Gly Cys Pro Glu Cys Arg Ser Gly Asp 
            260                 265                 270         


Cys His Tyr His Ser Ser Gln Leu Trp Pro Ser Thr Glu Gly Ala Pro 
        275                 280                 285             


Gly Pro Pro Arg Thr 
    290             


<210>  2099
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  2099

Met Tyr Phe Leu Thr Pro Ile Leu Val Ala Ile Leu Cys Ile Leu Val 
1               5                   10                  15      


Val Trp Ile Phe Lys Asn Ala Asp Arg Ser Met Glu Lys Lys Lys Gly 
            20                  25                  30          


Glu Pro Arg Thr Arg Ala Glu Ala Arg Pro Trp Val Asp Glu Asp Leu 
        35                  40                  45              


Lys Asp Ser Ser Asp Leu His Gln Ala Glu Glu Asp Ala Asp Glu Trp 
    50                  55                  60                  


Gln Glu Ser Glu Glu Asn Val Glu His Ile Pro Phe Ser His Asn His 
65                  70                  75                  80  


Tyr Pro Glu Lys Glu Met Val Lys Arg Ser Gln Glu Phe Tyr Glu Leu 
                85                  90                  95      


Leu Asn Lys Arg Arg Ser Val Arg Phe Ile Ser Asn Glu Gln Val Pro 
            100                 105                 110         


Met Glu Val Ile Asp Asn Val Ile Arg Thr Ala Gly Thr Ala Pro Ser 
        115                 120                 125             


Gly Ala His Thr Glu Pro Trp Thr Phe Val Val Val Lys Asp Pro Asp 
    130                 135                 140                 


Val Lys His Lys Ile Arg Lys Ile Ile Glu Glu Glu Glu Glu Ile Asn 
145                 150                 155                 160 


Tyr Met Lys Arg Met Gly His Arg Trp Val Thr Asp Leu Lys Lys Leu 
                165                 170                 175     


Arg Thr Asn Trp Ile Lys Glu Tyr Leu Asp Thr Ala Pro Ile Leu Ile 
            180                 185                 190         


Leu Ile Phe Lys Gln Val His Gly Phe Ala Ala Asn Gly Lys Lys Lys 
        195                 200                 205             


Val His Tyr Tyr Asn Glu Ile Ser Val Ser Ile Ala Cys Gly Ile Leu 
    210                 215                 220                 


Leu Ala Ala Leu Gln Val Phe Gly Lys Ile Ile Leu Lys Glu Leu Ala 
225                 230                 235                 240 


Leu Ile Ser Phe Leu Asn Leu 
                245         


<210>  2100
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  2100

Met Glu Pro His Asp Ser Ser His Met Asp Ser Glu Phe Arg Tyr Thr 
1               5                   10                  15      


Leu Phe Pro Ile Val Tyr Ser Ile Ile Phe Val Leu Gly Val Ile Ala 
            20                  25                  30          


Asn Gly Tyr Val Leu Trp Val Phe Ala Arg Leu Tyr Pro Cys Lys Lys 
        35                  40                  45              


Phe Asn Glu Ile Lys Ile Phe Met Val Asn Leu Thr Met Ala Asp Met 
    50                  55                  60                  


Leu Phe Leu Ile Thr Leu Pro Leu Trp Ile Val Tyr Tyr Gln Asn Gln 
65                  70                  75                  80  


Gly Asn Trp Ile Leu Pro Lys Phe Leu Cys Asn Val Ala Gly Cys Leu 
                85                  90                  95      


Phe Phe Ile Asn Thr Tyr Cys Ser Val Ala Phe Leu Gly Val Ile Thr 
            100                 105                 110         


Tyr Asn Arg Phe Gln Ala Val Thr Arg Pro Ile Lys Thr Ala Gln Ala 
        115                 120                 125             


Asn Thr Arg Lys Arg Gly Ile Ser Leu Ser Leu Val Ile Trp Val Ala 
    130                 135                 140                 


Ile Val Gly Ala Ala Ser Tyr Phe Leu Ile Leu Asp Ser Thr Asn Thr 
145                 150                 155                 160 


Val Pro Asp Ser Ala Gly Ser Gly Asn Val Thr Arg Cys Phe Glu His 
                165                 170                 175     


Tyr Glu Lys Gly Ser Val Pro Val Leu Ile Ile His Ile Phe Ile Val 
            180                 185                 190         


Phe Ser Phe Phe Leu Val Phe Leu Ile Ile Leu Phe Cys Asn Leu Val 
        195                 200                 205             


Ile Ile Arg Thr Leu Leu Met Gln Pro Val Gln Gln Gln Arg Asn Ala 
    210                 215                 220                 


Glu Val Lys Arg Arg Ala Leu Trp Met Val Cys Thr Val Leu Ala Val 
225                 230                 235                 240 


Phe Ile Ile Cys Phe Val Pro His His Val Val Gln Leu Pro Trp Thr 
                245                 250                 255     


Leu Ala Glu Leu Gly Phe Gln Asp Ser Lys Phe His Gln Ala Ile Asn 
            260                 265                 270         


Asp Ala His Gln Val Thr Leu Cys Leu Leu Ser Thr Asn Cys Val Leu 
        275                 280                 285             


Asp Pro Val Ile Tyr Cys Phe Leu Thr Lys Lys Phe Arg Lys His Leu 
    290                 295                 300                 


Thr Glu Lys Phe Tyr Ser Met Arg Ser Ser Arg Lys Cys Ser Arg Ala 
305                 310                 315                 320 


Thr Thr Asp Thr Val Thr Glu Val Val Val Pro Phe Asn Gln Ile Pro 
                325                 330                 335     


Gly Asn Ser Leu Lys Asn 
            340         


<210>  2101
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  2101

Met Glu Pro His Asp Ser Ser His Met Asp Ser Glu Phe Arg Tyr Thr 
1               5                   10                  15      


Leu Phe Pro Ile Val Tyr Ser Ile Ile Phe Val Leu Gly Val Ile Ala 
            20                  25                  30          


Asn Gly Tyr Val Leu Trp Val Phe Ala Arg Leu Tyr Pro Cys Lys Lys 
        35                  40                  45              


Phe Asn Glu Ile Lys Ile Phe Met Val Asn Leu Thr Met Ala Asp Met 
    50                  55                  60                  


Leu Phe Leu Ile Thr Leu Pro Leu Trp Ile Val Tyr Tyr Gln Asn Gln 
65                  70                  75                  80  


Gly Asn Trp Ile Leu Pro Lys Phe Leu Cys Asn Val Ala Gly Cys Leu 
                85                  90                  95      


Phe Phe Ile Asn Thr Tyr Cys Ser Val Ala Phe Leu Gly Val Ile Thr 
            100                 105                 110         


Tyr Asn Arg Phe Gln Ala Val Thr Arg Pro Ile Lys Thr Ala Gln Ala 
        115                 120                 125             


Asn Thr Arg Lys Arg Gly Ile Ser Leu Ser Leu Val Ile Trp Val Ala 
    130                 135                 140                 


Ile Val Gly Ala Ala Ser Tyr Phe Leu Ile Leu Asp Ser Thr Asn Thr 
145                 150                 155                 160 


Val Pro Asp Ser Ala Gly Ser Gly Asn Val Thr Arg Cys Phe Glu His 
                165                 170                 175     


Tyr Glu Lys Gly Ser Val Pro Val Leu Ile Ile His Ile Phe Ile Val 
            180                 185                 190         


Phe Ser Phe Phe Leu Val Phe Leu Ile Ile Leu Phe Cys Asn Leu Val 
        195                 200                 205             


Ile Ile Arg Thr Leu Leu Met Gln Pro Val Gln Gln Gln Arg Asn Ala 
    210                 215                 220                 


Glu Val Lys Arg Arg Ala Leu Trp Met Val Cys Thr Val Leu Ala Val 
225                 230                 235                 240 


Phe Ile Ile Cys Phe Val Pro His His Val Val Gln Leu Pro Trp Thr 
                245                 250                 255     


Leu Ala Glu Leu Gly Phe Gln Asp Ser Lys Phe His Gln Ala Ile Asn 
            260                 265                 270         


Asp Ala His Gln Val Thr Leu Cys Leu Leu Ser Thr Asn Cys Val Leu 
        275                 280                 285             


Asp Pro Val Ile Tyr Cys Phe Leu Thr Lys Lys Phe Arg Lys His Leu 
    290                 295                 300                 


Thr Glu Lys Phe Tyr Ser Met Arg Ser Ser Arg Lys Cys Ser Arg Ala 
305                 310                 315                 320 


Thr Thr Asp Thr Val Thr Glu Val Val Val Pro Phe Asn Gln Ile Pro 
                325                 330                 335     


Gly Asn Ser Leu Lys Asn 
            340         


<210>  2102
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  2102

Met Glu Pro His Asp Ser Ser His Met Asp Ser Glu Phe Arg Tyr Thr 
1               5                   10                  15      


Leu Phe Pro Ile Val Tyr Ser Ile Ile Phe Val Leu Gly Val Ile Ala 
            20                  25                  30          


Asn Gly Tyr Val Leu Trp Val Phe Ala Arg Leu Tyr Pro Cys Lys Lys 
        35                  40                  45              


Phe Asn Glu Ile Lys Ile Phe Met Val Asn Leu Thr Met Ala Asp Met 
    50                  55                  60                  


Leu Phe Leu Ile Thr Leu Pro Leu Trp Ile Val Tyr Tyr Gln Asn Gln 
65                  70                  75                  80  


Gly Asn Trp Ile Leu Pro Lys Phe Leu Cys Asn Val Ala Gly Cys Leu 
                85                  90                  95      


Phe Phe Ile Asn Thr Tyr Cys Ser Val Ala Phe Leu Gly Val Ile Thr 
            100                 105                 110         


Tyr Asn Arg Phe Gln Ala Val Thr Arg Pro Ile Lys Thr Ala Gln Ala 
        115                 120                 125             


Asn Thr Arg Lys Arg Gly Ile Ser Leu Ser Leu Val Ile Trp Val Ala 
    130                 135                 140                 


Ile Val Gly Ala Ala Ser Tyr Phe Leu Ile Leu Asp Ser Thr Asn Thr 
145                 150                 155                 160 


Val Pro Asp Ser Ala Gly Ser Gly Asn Val Thr Arg Cys Phe Glu His 
                165                 170                 175     


Tyr Glu Lys Gly Ser Val Pro Val Leu Ile Ile His Ile Phe Ile Val 
            180                 185                 190         


Phe Ser Phe Phe Leu Val Phe Leu Ile Ile Leu Phe Cys Asn Leu Val 
        195                 200                 205             


Ile Ile Arg Thr Leu Leu Met Gln Pro Val Gln Gln Gln Arg Asn Ala 
    210                 215                 220                 


Glu Val Lys Arg Arg Ala Leu Trp Met Val Cys Thr Val Leu Ala Val 
225                 230                 235                 240 


Phe Ile Ile Cys Phe Val Pro His His Val Val Gln Leu Pro Trp Thr 
                245                 250                 255     


Leu Ala Glu Leu Gly Phe Gln Asp Ser Lys Phe His Gln Ala Ile Asn 
            260                 265                 270         


Asp Ala His Gln Val Thr Leu Cys Leu Leu Ser Thr Asn Cys Val Leu 
        275                 280                 285             


Asp Pro Val Ile Tyr Cys Phe Leu Thr Lys Lys Phe Arg Lys His Leu 
    290                 295                 300                 


Thr Glu Lys Phe Tyr Ser Met Arg Ser Ser Arg Lys Cys Ser Arg Ala 
305                 310                 315                 320 


Thr Thr Asp Thr Val Thr Glu Val Val Val Pro Phe Asn Gln Ile Pro 
                325                 330                 335     


Gly Asn Ser Leu Lys Asn 
            340         


<210>  2103
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  2103

Met Gln Phe Ser Gly Glu Lys Ile Ser Gly Gln Arg Asp Leu Gln Lys 
1               5                   10                  15      


Ser Lys Met Arg Phe Thr Phe Thr Ser Arg Cys Leu Ala Leu Phe Leu 
            20                  25                  30          


Leu Leu Asn His Pro Thr Pro Ile Leu Pro Ala Phe Ser Asn Gln Thr 
        35                  40                  45              


Tyr Pro Thr Ile Glu Pro Lys Pro Phe Leu Tyr Val Val Gly Arg Lys 
    50                  55                  60                  


Lys Met Met Asp Ala Gln Tyr Lys Cys Tyr Asp Arg Met Gln Gln Leu 
65                  70                  75                  80  


Pro Ala Tyr Gln Gly Glu Gly Pro Tyr Cys Asn Arg Thr Trp Asp Gly 
                85                  90                  95      


Trp Leu Cys Trp Asp Asp Thr Pro Ala Gly Val Leu Ser Tyr Gln Phe 
            100                 105                 110         


Cys Pro Asp Tyr Phe Pro Asp Phe Asp Pro Ser Glu Lys Val Thr Lys 
        115                 120                 125             


Tyr Cys Asp Glu Lys Gly Val Trp Phe Lys His Pro Glu Asn Asn Arg 
    130                 135                 140                 


Thr Trp Ser Asn Tyr Thr Met Cys Asn Ala Phe Thr Pro Glu Lys Leu 
145                 150                 155                 160 


Lys Asn Ala Tyr Val Leu Tyr Tyr Leu Ala Ile Val Gly His Ser Leu 
                165                 170                 175     


Ser Ile Phe Thr Leu Val Ile Ser Leu Gly Ile Phe Val Phe Phe Arg 
            180                 185                 190         


Lys Leu Thr Thr Ile Phe Pro Leu Asn Trp Lys Tyr Arg Lys Ala Leu 
        195                 200                 205             


Ser Leu Gly Cys Gln Arg Val Thr Leu His Lys Asn Met Phe Leu Thr 
    210                 215                 220                 


Tyr Ile Leu Asn Ser Met Ile Ile Ile Ile His Leu Val Glu Val Val 
225                 230                 235                 240 


Pro Asn Gly Glu Leu Val Arg Arg Asp Pro Val Ser Cys Lys Ile Leu 
                245                 250                 255     


His Phe Phe His Gln Tyr Met Met Ala Cys Asn Tyr Phe Trp Met Leu 
            260                 265                 270         


Cys Glu Gly Ile Tyr Leu His Thr Leu Ile Val Val Ala Val Phe Thr 
        275                 280                 285             


Glu Lys Gln Arg Leu Arg Trp Tyr Tyr Leu Leu Gly Trp Gly Phe Pro 
    290                 295                 300                 


Leu Val Pro Thr Thr Ile His Ala Ile Thr Arg Ala Val Tyr Phe Asn 
305                 310                 315                 320 


Asp Asn Cys Trp Leu Ser Val Glu Thr His Leu Leu Tyr Ile Ile His 
                325                 330                 335     


Gly Pro Val Met Ala Ala Leu Val Val Asn Phe Phe Phe Leu Leu Asn 
            340                 345                 350         


Ile Val Arg Val Leu Val Thr Lys Met Arg Glu Thr His Glu Ala Glu 
        355                 360                 365             


Ser His Met Tyr Leu Lys Ala Val Lys Ala Thr Met Ile Leu Val Pro 
    370                 375                 380                 


Leu Leu Gly Ile Gln Phe Val Val Phe Pro Trp Arg Pro Ser Asn Lys 
385                 390                 395                 400 


Met Leu Gly Lys Ile Tyr Asp Tyr Val Met His Ser Leu Ile His Phe 
                405                 410                 415     


Gln Gly Phe Phe Val Ala Thr Ile Tyr Cys Phe Cys Asn Asn Glu Val 
            420                 425                 430         


Gln Thr Thr Val Lys Arg Gln Trp Ala Gln Phe Lys Ile Gln Trp Asn 
        435                 440                 445             


Gln Arg Trp Gly Arg Arg Pro Ser Asn Arg Ser Ala Arg Ala Ala Ala 
    450                 455                 460                 


Ala Ala Ala Glu Ala Gly Asp Ile Pro Ile Tyr Ile Cys His Gln Glu 
465                 470                 475                 480 


Leu Arg Asn Glu Pro Ala Asn Asn Gln Gly Glu Glu Ser Ala Glu Ile 
                485                 490                 495     


Ile Pro Leu Asn Ile Ile Glu Gln Glu Ser Ser Ala 
            500                 505             


<210>  2104
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  2104

Met Arg Phe Thr Phe Thr Ser Arg Cys Leu Ala Leu Phe Leu Leu Leu 
1               5                   10                  15      


Asn His Pro Thr Pro Ile Leu Pro Ala Phe Ser Asn Gln Thr Tyr Pro 
            20                  25                  30          


Thr Ile Glu Pro Lys Pro Phe Leu Tyr Val Val Gly Arg Lys Lys Met 
        35                  40                  45              


Met Asp Ala Gln Tyr Lys Cys Tyr Asp Arg Met Gln Gln Leu Pro Ala 
    50                  55                  60                  


Tyr Gln Gly Glu Gly Pro Tyr Cys Asn Arg Thr Trp Asp Gly Trp Leu 
65                  70                  75                  80  


Cys Trp Asp Asp Thr Pro Ala Gly Val Leu Ser Tyr Gln Phe Cys Pro 
                85                  90                  95      


Asp Tyr Phe Pro Asp Phe Asp Pro Ser Glu Lys Val Thr Lys Tyr Cys 
            100                 105                 110         


Asp Glu Lys Gly Val Trp Phe Lys His Pro Glu Asn Asn Arg Thr Trp 
        115                 120                 125             


Ser Asn Tyr Thr Met Cys Asn Ala Phe Thr Pro Glu Lys Leu Lys Asn 
    130                 135                 140                 


Ala Tyr Val Leu Tyr Tyr Leu Ala Ile Val Gly His Ser Leu Ser Ile 
145                 150                 155                 160 


Phe Thr Leu Val Ile Ser Leu Gly Ile Phe Val Phe Phe Arg Ser Leu 
                165                 170                 175     


Gly Cys Gln Arg Val Thr Leu His Lys Asn Met Phe Leu Thr Tyr Ile 
            180                 185                 190         


Leu Asn Ser Met Ile Ile Ile Ile His Leu Val Glu Val Val Pro Asn 
        195                 200                 205             


Gly Glu Leu Val Arg Arg Asp Pro Val Ser Cys Lys Ile Leu His Phe 
    210                 215                 220                 


Phe His Gln Tyr Met Met Ala Cys Asn Tyr Phe Trp Met Leu Cys Glu 
225                 230                 235                 240 


Gly Ile Tyr Leu His Thr Leu Ile Val Val Ala Val Phe Thr Glu Lys 
                245                 250                 255     


Gln Arg Leu Arg Trp Tyr Tyr Leu Leu Gly Trp Gly Phe Pro Leu Val 
            260                 265                 270         


Pro Thr Thr Ile His Ala Ile Thr Arg Ala Val Tyr Phe Asn Asp Asn 
        275                 280                 285             


Cys Trp Leu Ser Val Glu Thr His Leu Leu Tyr Ile Ile His Gly Pro 
    290                 295                 300                 


Val Met Ala Ala Leu Val Val Asn Phe Phe Phe Leu Leu Asn Ile Val 
305                 310                 315                 320 


Arg Val Leu Val Thr Lys Met Arg Glu Thr His Glu Ala Glu Ser His 
                325                 330                 335     


Met Tyr Leu Lys Ala Val Lys Ala Thr Met Ile Leu Val Pro Leu Leu 
            340                 345                 350         


Gly Ile Gln Phe Val Val Phe Pro Trp Arg Pro Ser Asn Lys Met Leu 
        355                 360                 365             


Gly Lys Ile Tyr Asp Tyr Val Met His Ser Leu Ile His Phe Gln Gly 
    370                 375                 380                 


Phe Phe Val Ala Thr Ile Tyr Cys Phe Cys Asn Asn Glu Val Gln Thr 
385                 390                 395                 400 


Thr Val Lys Arg Gln Trp Ala Gln Phe Lys Ile Gln Trp Asn Gln Arg 
                405                 410                 415     


Trp Gly Arg Arg Pro Ser Asn Arg Ser Ala Arg Ala Ala Ala Ala Ala 
            420                 425                 430         


Ala Glu Ala Gly Asp Ile Pro Ile Tyr Ile Cys His Gln Glu Leu Arg 
        435                 440                 445             


Asn Glu Pro Ala Asn Asn Gln Gly Glu Glu Ser Ala Glu Ile Ile Pro 
    450                 455                 460                 


Leu Asn Ile Ile Glu Gln Glu Ser Ser Ala 
465                 470                 


<210>  2105
<211>  729
<212>  PRT
<213>  Homo sapiens

<400>  2105

Met Ala Glu Asp Lys Glu Thr Lys His Gly Gly His Lys Asn Gly Arg 
1               5                   10                  15      


Lys Gly Gly Leu Ser Gly Thr Ser Phe Phe Thr Trp Phe Met Val Ile 
            20                  25                  30          


Ala Leu Leu Gly Val Trp Thr Ser Val Ala Val Val Trp Phe Asp Leu 
        35                  40                  45              


Val Asp Tyr Glu Glu Val Leu Gly Lys Leu Gly Ile Tyr Asp Ala Asp 
    50                  55                  60                  


Gly Asp Gly Asp Phe Asp Val Asp Asp Ala Lys Val Leu Leu Gly Leu 
65                  70                  75                  80  


Lys Glu Arg Ser Thr Ser Glu Pro Ala Val Pro Pro Glu Glu Ala Glu 
                85                  90                  95      


Pro His Thr Glu Pro Glu Glu Gln Val Pro Val Glu Ala Glu Pro Gln 
            100                 105                 110         


Asn Ile Glu Asp Glu Ala Lys Glu Gln Ile Gln Ser Leu Leu His Glu 
        115                 120                 125             


Met Val His Ala Glu His Val Glu Gly Glu Asp Leu Gln Gln Glu Asp 
    130                 135                 140                 


Gly Pro Thr Gly Glu Pro Gln Gln Glu Asp Asp Glu Phe Leu Met Ala 
145                 150                 155                 160 


Thr Asp Val Asp Asp Arg Phe Glu Thr Leu Glu Pro Glu Val Ser His 
                165                 170                 175     


Glu Glu Thr Glu His Ser Tyr His Val Glu Glu Thr Val Ser Gln Asp 
            180                 185                 190         


Cys Asn Gln Asp Met Glu Glu Met Met Ser Glu Gln Glu Asn Pro Asp 
        195                 200                 205             


Ser Ser Glu Pro Val Val Glu Asp Glu Arg Leu His His Asp Thr Asp 
    210                 215                 220                 


Asp Val Thr Tyr Gln Val Tyr Glu Glu Gln Ala Val Tyr Glu Pro Leu 
225                 230                 235                 240 


Glu Asn Glu Gly Ile Glu Ile Thr Glu Val Thr Ala Pro Pro Glu Asp 
                245                 250                 255     


Asn Pro Val Glu Asp Ser Gln Val Ile Val Glu Glu Val Ser Ile Phe 
            260                 265                 270         


Pro Val Glu Glu Gln Gln Glu Val Pro Pro Glu Thr Asn Arg Lys Thr 
        275                 280                 285             


Asp Asp Pro Glu Gln Lys Ala Lys Val Lys Lys Lys Lys Pro Lys Leu 
    290                 295                 300                 


Leu Asn Lys Phe Asp Lys Thr Ile Lys Ala Glu Leu Asp Ala Ala Glu 
305                 310                 315                 320 


Lys Leu Arg Lys Arg Gly Lys Ile Glu Glu Ala Val Asn Ala Phe Lys 
                325                 330                 335     


Glu Leu Val Arg Lys Tyr Pro Gln Ser Pro Arg Ala Arg Tyr Gly Lys 
            340                 345                 350         


Ala Gln Cys Glu Asp Asp Leu Ala Glu Lys Arg Arg Ser Asn Glu Val 
        355                 360                 365             


Leu Arg Gly Ala Ile Glu Thr Tyr Gln Glu Val Ala Ser Leu Pro Asp 
    370                 375                 380                 


Val Pro Ala Asp Leu Leu Lys Leu Ser Leu Lys Arg Arg Ser Asp Arg 
385                 390                 395                 400 


Gln Gln Phe Leu Gly His Met Arg Gly Ser Leu Leu Thr Leu Gln Arg 
                405                 410                 415     


Leu Val Gln Leu Phe Pro Asn Asp Thr Ser Leu Lys Asn Asp Leu Gly 
            420                 425                 430         


Val Gly Tyr Leu Leu Ile Gly Asp Asn Asp Asn Ala Lys Lys Val Tyr 
        435                 440                 445             


Glu Glu Val Leu Ser Val Thr Pro Asn Asp Gly Phe Ala Lys Val His 
    450                 455                 460                 


Tyr Gly Phe Ile Leu Lys Ala Gln Asn Lys Ile Ala Glu Ser Ile Pro 
465                 470                 475                 480 


Tyr Leu Lys Glu Gly Ile Glu Ser Gly Asp Pro Gly Thr Asp Asp Gly 
                485                 490                 495     


Arg Phe Tyr Phe His Leu Gly Asp Ala Met Gln Arg Val Gly Asn Lys 
            500                 505                 510         


Glu Ala Tyr Lys Trp Tyr Glu Leu Gly His Lys Arg Gly His Phe Ala 
        515                 520                 525             


Ser Val Trp Gln Arg Ser Leu Tyr Asn Val Asn Gly Leu Lys Ala Gln 
    530                 535                 540                 


Pro Trp Trp Thr Pro Lys Glu Thr Gly Tyr Thr Glu Leu Val Lys Ser 
545                 550                 555                 560 


Leu Glu Arg Asn Trp Lys Leu Ile Arg Asp Glu Gly Leu Ala Val Met 
                565                 570                 575     


Asp Lys Ala Lys Gly Leu Phe Leu Pro Glu Asp Glu Asn Leu Arg Glu 
            580                 585                 590         


Lys Gly Asp Trp Ser Gln Phe Thr Leu Trp Gln Gln Gly Arg Arg Asn 
        595                 600                 605             


Glu Asn Ala Cys Lys Gly Ala Pro Lys Thr Cys Thr Leu Leu Glu Lys 
    610                 615                 620                 


Phe Pro Glu Thr Thr Gly Cys Arg Arg Gly Gln Ile Lys Tyr Ser Ile 
625                 630                 635                 640 


Met His Pro Gly Thr His Val Trp Pro His Thr Gly Pro Thr Asn Cys 
                645                 650                 655     


Arg Leu Arg Met His Leu Gly Leu Val Ile Pro Lys Glu Gly Cys Lys 
            660                 665                 670         


Ile Arg Cys Ala Asn Glu Thr Lys Thr Trp Glu Glu Gly Lys Val Leu 
        675                 680                 685             


Ile Phe Asp Asp Ser Phe Glu His Glu Val Trp Gln Asp Ala Ser Ser 
    690                 695                 700                 


Phe Arg Leu Ile Phe Ile Val Asp Val Trp His Pro Glu Leu Thr Pro 
705                 710                 715                 720 


Gln Gln Arg Arg Ser Leu Pro Ala Ile 
                725                 


<210>  2106
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  2106

Met Ala Glu Asp Lys Glu Thr Lys His Gly Gly His Lys Asn Gly Arg 
1               5                   10                  15      


Lys Gly Gly Leu Ser Gly Thr Ser Phe Phe Thr Trp Phe Met Val Ile 
            20                  25                  30          


Ala Leu Leu Gly Val Trp Thr Ser Val Ala Val Val Trp Phe Asp Leu 
        35                  40                  45              


Val Asp Tyr Glu Glu Val Leu Ala Lys Ala Lys Asp Phe Arg Tyr Asn 
    50                  55                  60                  


Leu Ser Glu Val Leu Gln Gly Lys Leu Gly Ile Tyr Asp Ala Asp Gly 
65                  70                  75                  80  


Asp Gly Asp Phe Asp Val Asp Asp Ala Lys Val Leu Leu Gly Leu Lys 
                85                  90                  95      


Glu Arg Ser Thr Ser Glu Pro Ala Val Pro Pro Glu Glu Ala Glu Pro 
            100                 105                 110         


His Thr Glu Pro Glu Glu Gln Val Pro Val Glu Ala Glu Pro Gln Asn 
        115                 120                 125             


Ile Glu Asp Glu Ala Lys Glu Gln Ile Gln Ser Leu Leu His Glu Met 
    130                 135                 140                 


Val His Ala Glu His Val Glu Gly Glu Asp Leu Gln Gln Glu Asp Gly 
145                 150                 155                 160 


Pro Thr Gly Glu Pro Gln Gln Glu Asp Asp Glu Phe Leu Met Ala Thr 
                165                 170                 175     


Asp Val Asp Asp Arg Phe Glu Thr Leu Glu Pro Glu Val Ser His Glu 
            180                 185                 190         


Glu Thr Glu His Ser Tyr His Val Glu Glu Thr Val Ser Gln Asp Cys 
        195                 200                 205             


Asn Gln Asp Met Glu Glu Met Met Ser Glu Gln Glu Asn Pro Asp Ser 
    210                 215                 220                 


Ser Glu Pro Val Val Glu Asp Glu Arg Leu His His Asp Thr Asp Asp 
225                 230                 235                 240 


Val Thr Tyr Gln Val Tyr Glu Glu Gln Val Tyr Glu Pro Leu Glu Asn 
                245                 250                 255     


Glu Gly Ile Glu Ile Thr Glu Val Thr Ala Pro Pro Glu Asp Asn Pro 
            260                 265                 270         


Val Glu Asp Ser Gln Val Ile Val Glu Glu Val Ser Ile Phe Pro Val 
        275                 280                 285             


Glu Glu Gln Gln Glu Val Pro Pro Asp Thr 
    290                 295             


<210>  2107
<211>  279
<212>  PRT
<213>  Homo sapiens

<400>  2107

Met Ala Glu Asp Lys Glu Thr Lys His Gly Gly His Lys Asn Gly Arg 
1               5                   10                  15      


Lys Gly Gly Leu Ser Gly Thr Ser Phe Phe Thr Trp Phe Met Val Ile 
            20                  25                  30          


Ala Leu Leu Gly Val Trp Thr Ser Val Ala Val Val Trp Phe Asp Leu 
        35                  40                  45              


Val Asp Tyr Glu Glu Val Leu Ala Lys Ala Lys Asp Phe Arg Tyr Asn 
    50                  55                  60                  


Leu Ser Glu Val Leu Gln Gly Lys Leu Gly Ile Tyr Asp Ala Asp Gly 
65                  70                  75                  80  


Asp Gly Asp Phe Asp Val Asp Asp Ala Lys Val Leu Leu Gly Leu Lys 
                85                  90                  95      


Glu Arg Ser Thr Ser Glu Pro Ala Val Pro Pro Glu Glu Ala Glu Pro 
            100                 105                 110         


His Thr Glu Pro Glu Glu Gln Val Pro Val Glu Ala Glu Pro Gln Asn 
        115                 120                 125             


Ile Glu Asp Glu Ala Lys Glu Gln Ile Gln Ser Leu Leu His Glu Met 
    130                 135                 140                 


Val His Ala Glu His Val Glu Gly Glu Asp Leu Gln Gln Glu Asp Gly 
145                 150                 155                 160 


Pro Thr Gly Glu Pro Gln Gln Glu Asp Asp Glu Phe Leu Met Ala Thr 
                165                 170                 175     


Asp Val Asp Asp Arg Phe Glu Thr Leu Glu Pro Glu Val Ser His Glu 
            180                 185                 190         


Glu Thr Glu His Ser Tyr His Val Glu Glu Thr Asp Ser Ser Glu Pro 
        195                 200                 205             


Val Val Glu Asp Glu Arg Leu His His Asp Thr Asp Asp Val Thr Tyr 
    210                 215                 220                 


Gln Val Tyr Glu Glu Gln Val Tyr Glu Pro Leu Glu Asn Glu Gly Ile 
225                 230                 235                 240 


Glu Ile Thr Glu Val Thr Ala Pro Pro Glu Asp Asn Pro Val Glu Asp 
                245                 250                 255     


Ser Gln Val Ile Val Glu Glu Val Ser Ile Phe Pro Val Glu Glu Gln 
            260                 265                 270         


Gln Glu Val Pro Pro Asp Thr 
        275                 


<210>  2108
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  2108

Met Ala Glu Asp Lys Glu Thr Lys His Gly Gly His Lys Asn Gly Arg 
1               5                   10                  15      


Lys Gly Gly Leu Ser Gly Thr Ser Phe Phe Thr Trp Phe Met Val Ile 
            20                  25                  30          


Ala Leu Leu Gly Val Trp Thr Ser Val Ala Val Val Trp Phe Asp Leu 
        35                  40                  45              


Val Asp Tyr Glu Glu Val Leu Ala Lys Ala Lys Asp Phe Arg Tyr Asn 
    50                  55                  60                  


Leu Ser Glu Val Leu Gln Gly Lys Leu Gly Ile Tyr Asp Ala Asp Gly 
65                  70                  75                  80  


Asp Gly Asp Phe Asp Val Asp Asp Ala Lys Val Leu Leu Gly Leu Lys 
                85                  90                  95      


Glu Arg Ser Thr Ser Glu Pro Ala Val Pro Pro Glu Glu Ala Glu Pro 
            100                 105                 110         


His Thr Glu Pro Glu Glu Gln Val Pro Val Glu Ala Glu Pro Gln Asn 
        115                 120                 125             


Ile Glu Asp Glu Ala Lys Glu Gln Ile Gln Ser Leu Leu His Glu Met 
    130                 135                 140                 


Val His Ala Glu His Glu Thr Glu His Ser Tyr His Val Glu Glu Thr 
145                 150                 155                 160 


Val Ser Gln Asp Cys Asn Gln Asp Met Glu Glu Met Met Ser Glu Gln 
                165                 170                 175     


Glu Asn Pro Asp Ser Ser Glu Pro Val Val Glu Asp Glu Arg Leu His 
            180                 185                 190         


His Asp Thr Asp Asp Val Thr Tyr Gln Val Tyr Glu Glu Gln Ala Val 
        195                 200                 205             


Tyr Glu Pro Leu Glu Asn Glu Gly Ile Glu Ile Thr Glu Val Thr Ala 
    210                 215                 220                 


Pro Pro Glu Asp Asn Pro Val Glu Asp Ser Gln Val Ile Val Glu Glu 
225                 230                 235                 240 


Val Ser Ile Phe Pro Val Glu Glu Gln Gln Glu Val Pro Pro Asp Thr 
                245                 250                 255     


<210>  2109
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  2109

Met Ala Gln Arg Lys Asn Ala Lys Ser Ser Gly Asn Ser Ser Ser Ser 
1               5                   10                  15      


Gly Ser Gly Ser Gly Ser Thr Ser Ala Gly Ser Ser Ser Pro Gly Ala 
            20                  25                  30          


Arg Arg Glu Thr Lys His Gly Gly His Lys Asn Gly Arg Lys Gly Gly 
        35                  40                  45              


Leu Ser Gly Thr Ser Phe Phe Thr Trp Phe Met Val Ile Ala Leu Leu 
    50                  55                  60                  


Gly Val Trp Thr Ser Val Ala Val Val Trp Phe Asp Leu Val Asp Tyr 
65                  70                  75                  80  


Glu Glu Val Leu Gly Lys Leu Gly Ile Tyr Asp Ala Asp Gly Asp Gly 
                85                  90                  95      


Asp Phe Asp Val Asp Asp Ala Lys Val Leu Leu Gly Leu Lys Glu Arg 
            100                 105                 110         


Ser Thr Ser Glu Pro Ala Val Pro Pro Glu Glu Ala Glu Pro His Thr 
        115                 120                 125             


Glu Pro Glu Glu Gln Val Pro Val Glu Ala Glu Pro Gln Asn Ile Glu 
    130                 135                 140                 


Asp Glu Ala Lys Glu Gln Ile Gln Ser Leu Leu His Glu Met Val His 
145                 150                 155                 160 


Ala Glu His Val Glu Gly Glu Asp Leu Gln Gln Glu Asp Gly Pro Thr 
                165                 170                 175     


Gly Glu Pro Gln Gln Glu Asp Asp Glu Phe Leu Met Ala Thr Asp Val 
            180                 185                 190         


Asp Asp Arg Phe Glu Thr Leu Glu Pro Glu Val Ser His Glu Glu Thr 
        195                 200                 205             


Glu His Ser Tyr His Val Glu Glu Thr Asp Ser Ser Glu Pro Val Val 
    210                 215                 220                 


Glu Asp Glu Arg Leu His His Asp Thr Asp Asp Val Thr Tyr Gln Val 
225                 230                 235                 240 


Tyr Glu Glu Gln Ala Val Tyr Glu Pro Leu Glu Asn Glu Gly Ile Glu 
                245                 250                 255     


Ile Thr Glu Val Thr Ala Pro Pro Glu Asp Asn Pro Val Glu Asp Ser 
            260                 265                 270         


Gln Val Ile Val Glu Glu Val Ser Ile Phe Pro Val Glu Glu Gln Gln 
        275                 280                 285             


Glu Val Pro Pro Asp Thr 
    290                 


<210>  2110
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  2110

Met Ala Gln Arg Lys Asn Ala Lys Ser Ser Gly Asn Ser Ser Ser Ser 
1               5                   10                  15      


Gly Ser Gly Ser Gly Ser Thr Ser Ala Gly Ser Ser Ser Pro Gly Ala 
            20                  25                  30          


Arg Arg Glu Thr Lys His Gly Gly His Lys Asn Gly Arg Lys Gly Gly 
        35                  40                  45              


Leu Ser Gly Thr Ser Phe Phe Thr Trp Phe Met Val Ile Ala Leu Leu 
    50                  55                  60                  


Gly Val Trp Thr Ser Val Ala Val Val Trp Phe Asp Leu Val Asp Tyr 
65                  70                  75                  80  


Glu Glu Val Leu Gly Lys Leu Gly Ile Tyr Asp Ala Asp Gly Asp Gly 
                85                  90                  95      


Asp Phe Asp Val Asp Asp Ala Lys Val Leu Leu Gly Leu Lys Glu Arg 
            100                 105                 110         


Ser Thr Ser Glu Pro Ala Val Pro Pro Glu Glu Ala Glu Pro His Thr 
        115                 120                 125             


Glu Pro Glu Glu Gln Val Pro Val Glu Ala Glu Pro Gln Asn Ile Glu 
    130                 135                 140                 


Asp Glu Ala Lys Glu Gln Ile Gln Ser Leu Leu His Glu Met Val His 
145                 150                 155                 160 


Ala Glu His Glu Thr Glu His Ser Tyr His Val Glu Glu Thr Val Ser 
                165                 170                 175     


Gln Asp Cys Asn Gln Asp Met Glu Glu Met Met Ser Glu Gln Glu Asn 
            180                 185                 190         


Pro Asp Ser Ser Glu Pro Val Val Glu Asp Glu Arg Leu His His Asp 
        195                 200                 205             


Thr Asp Asp Val Thr Tyr Gln Val Tyr Glu Glu Gln Ala Val Tyr Glu 
    210                 215                 220                 


Pro Leu Glu Asn Glu Gly Ile Glu Ile Thr Glu Val Thr Ala Pro Pro 
225                 230                 235                 240 


Glu Asp Asn Pro Val Glu Asp Ser Gln Val Ile Val Glu Glu Val Ser 
                245                 250                 255     


Ile Phe Pro Val Glu Glu Gln Gln Glu Val Pro Pro Asp Thr 
            260                 265                 270 


<210>  2111
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  2111

Met Ala Gln Arg Lys Asn Ala Lys Ser Ser Gly Asn Ser Ser Ser Ser 
1               5                   10                  15      


Gly Ser Gly Ser Gly Ser Thr Ser Ala Gly Ser Ser Ser Pro Gly Ala 
            20                  25                  30          


Arg Arg Glu Thr Lys His Gly Gly His Lys Asn Gly Arg Lys Gly Gly 
        35                  40                  45              


Leu Ser Gly Thr Ser Phe Phe Thr Trp Phe Met Val Ile Ala Leu Leu 
    50                  55                  60                  


Gly Val Trp Thr Ser Val Ala Val Val Trp Phe Asp Leu Val Asp Tyr 
65                  70                  75                  80  


Glu Glu Val Leu Ala Lys Ala Lys Asp Phe Arg Tyr Asn Leu Ser Glu 
                85                  90                  95      


Val Leu Gln Gly Lys Leu Gly Ile Tyr Asp Ala Asp Gly Asp Gly Asp 
            100                 105                 110         


Phe Asp Val Asp Asp Ala Lys Val Leu Leu Gly Leu Thr Lys Asp Gly 
        115                 120                 125             


Ser Asn Glu Asn Ile Asp Ser Leu Glu Glu Val Leu Asn Ile Leu Ala 
    130                 135                 140                 


Glu Glu Ser Ser Asp Trp Phe Tyr Gly Phe Leu Ser Phe Leu Tyr Asp 
145                 150                 155                 160 


Ile Met Thr Pro Phe Glu Met Leu Glu Glu Glu Glu Glu Glu Ser Glu 
                165                 170                 175     


Thr Ala Asp Gly Val Asp Gly Thr Ser Gln Asn Glu Gly Val Gln Gly 
            180                 185                 190         


Lys Thr Cys Val Ile Leu Asp Leu His Asn Gln 
        195                 200             


<210>  2112
<211>  698
<212>  PRT
<213>  Homo sapiens

<400>  2112

Met Lys Ile Glu Thr Ser Gly Tyr Asn Ser Asp Lys Leu Ile Cys Arg 
1               5                   10                  15      


Gly Phe Ile Gly Thr Pro Ala Pro Pro Val Cys Asp Ser Lys Phe Leu 
            20                  25                  30          


Leu Ser Pro Ser Ser Asp Val Arg Met Ile Pro Cys Arg Ala Ala Leu 
        35                  40                  45              


Thr Phe Ala Arg Cys Leu Ile Arg Arg Lys Ile Val Thr Leu Asp Ser 
    50                  55                  60                  


Leu Glu Asp Thr Lys Leu Cys Arg Cys Leu Ser Thr Met Asp Leu Ile 
65                  70                  75                  80  


Ala Leu Gly Val Gly Ser Thr Leu Gly Ala Gly Val Tyr Val Leu Ala 
                85                  90                  95      


Gly Glu Val Ala Lys Ala Asp Ser Gly Pro Ser Ile Val Val Ser Phe 
            100                 105                 110         


Leu Ile Ala Ala Leu Ala Ser Val Met Ala Gly Leu Cys Tyr Ala Glu 
        115                 120                 125             


Phe Gly Ala Arg Val Pro Lys Thr Gly Ser Ala Tyr Leu Tyr Thr Tyr 
    130                 135                 140                 


Val Thr Val Gly Glu Leu Trp Ala Phe Ile Thr Gly Trp Asn Leu Ile 
145                 150                 155                 160 


Leu Ser Tyr Val Ile Gly Thr Ser Ser Val Ala Arg Ala Trp Ser Gly 
                165                 170                 175     


Thr Phe Asp Glu Leu Leu Ser Lys Gln Ile Gly Gln Phe Leu Arg Thr 
            180                 185                 190         


Tyr Phe Arg Met Asn Tyr Thr Gly Leu Ala Glu Tyr Pro Asp Phe Phe 
        195                 200                 205             


Ala Val Cys Leu Ile Leu Leu Leu Ala Gly Leu Leu Ser Phe Gly Val 
    210                 215                 220                 


Lys Glu Ser Ala Trp Val Asn Lys Val Phe Thr Ala Val Asn Ile Leu 
225                 230                 235                 240 


Val Leu Leu Phe Val Met Val Ala Gly Phe Val Lys Gly Asn Val Ala 
                245                 250                 255     


Asn Trp Lys Ile Ser Glu Glu Phe Leu Lys Asn Ile Ser Ala Ser Ala 
            260                 265                 270         


Arg Glu Pro Pro Ser Glu Asn Gly Thr Ser Ile Tyr Gly Ala Gly Gly 
        275                 280                 285             


Phe Met Pro Tyr Gly Phe Thr Gly Thr Leu Ala Gly Ala Ala Thr Cys 
    290                 295                 300                 


Phe Tyr Ala Phe Val Gly Phe Asp Cys Ile Ala Thr Thr Gly Glu Glu 
305                 310                 315                 320 


Val Arg Asn Pro Gln Lys Ala Ile Pro Ile Gly Ile Val Thr Ser Leu 
                325                 330                 335     


Leu Val Cys Phe Met Ala Tyr Phe Gly Val Ser Ala Ala Leu Thr Leu 
            340                 345                 350         


Met Met Pro Tyr Tyr Leu Leu Asp Glu Lys Ser Pro Leu Pro Val Ala 
        355                 360                 365             


Phe Glu Tyr Val Gly Trp Gly Pro Ala Lys Tyr Val Val Ala Ala Gly 
    370                 375                 380                 


Ser Leu Cys Ala Leu Ser Thr Ser Leu Leu Gly Ser Ile Phe Pro Met 
385                 390                 395                 400 


Pro Arg Val Ile Tyr Ala Met Ala Glu Asp Gly Leu Leu Phe Lys Cys 
                405                 410                 415     


Leu Ala Gln Ile Asn Ser Lys Thr Lys Thr Pro Ile Ile Ala Thr Leu 
            420                 425                 430         


Ser Ser Gly Ala Val Ala Ala Leu Met Ala Phe Leu Phe Asp Leu Lys 
        435                 440                 445             


Ala Leu Val Asp Met Met Ser Ile Gly Thr Leu Met Ala Tyr Ser Leu 
    450                 455                 460                 


Val Ala Ala Cys Val Leu Ile Leu Arg Tyr Gln Pro Gly Leu Ser Tyr 
465                 470                 475                 480 


Asp Gln Pro Lys Cys Ser Pro Glu Lys Asp Gly Leu Gly Ser Ser Pro 
                485                 490                 495     


Arg Val Thr Ser Lys Ser Glu Ser Gln Val Thr Met Leu Gln Arg Gln 
            500                 505                 510         


Gly Phe Ser Met Arg Thr Leu Phe Cys Pro Ser Leu Leu Pro Thr Gln 
        515                 520                 525             


Gln Ser Ala Ser Leu Val Ser Phe Leu Val Gly Phe Leu Ala Phe Leu 
    530                 535                 540                 


Val Leu Gly Leu Ser Val Leu Thr Thr Tyr Gly Val His Ala Ile Thr 
545                 550                 555                 560 


Arg Leu Glu Ala Trp Ser Leu Ala Leu Leu Ala Leu Phe Leu Val Leu 
                565                 570                 575     


Phe Val Ala Ile Val Leu Thr Ile Trp Arg Gln Pro Gln Asn Gln Gln 
            580                 585                 590         


Lys Val Ala Phe Met Val Pro Phe Leu Pro Phe Leu Pro Ala Phe Ser 
        595                 600                 605             


Ile Leu Val Asn Ile Tyr Leu Met Val Gln Leu Ser Ala Asp Thr Trp 
    610                 615                 620                 


Val Arg Phe Ser Ile Trp Met Ala Ile Gly Phe Leu Ile Tyr Phe Ser 
625                 630                 635                 640 


Tyr Gly Ile Arg His Ser Leu Glu Gly His Leu Arg Asp Glu Asn Asn 
                645                 650                 655     


Glu Glu Asp Ala Tyr Pro Asp Asn Val His Ala Ala Ala Glu Glu Lys 
            660                 665                 670         


Ser Ala Ile Gln Ala Asn Asp His His Pro Arg Asn Leu Ser Ser Pro 
        675                 680                 685             


Phe Ile Phe His Glu Lys Thr Ser Glu Phe 
    690                 695             


<210>  2113
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  2113

Met Lys His Met Leu Ala Ala Ser Ala Gly Glu Val Val Ala Cys Leu 
1               5                   10                  15      


Ile Arg Val Pro Ser Glu Val Val Lys Gln Arg Ala Gln Val Ser Ala 
            20                  25                  30          


Ser Thr Arg Thr Phe Gln Ile Phe Ser Asn Ile Leu Tyr Glu Glu Gly 
        35                  40                  45              


Ile Gln Gly Leu Tyr Arg Gly Tyr Lys Ser Thr Val Leu Arg Glu Ile 
    50                  55                  60                  


Pro Phe Ser Leu Val Gln Phe Pro Leu Trp Glu Ser Leu Lys Ala Leu 
65                  70                  75                  80  


Trp Ser Trp Arg Gln Asp His Val Val Asp Ser Trp Gln Ser Ala Val 
                85                  90                  95      


Cys Gly Ala Phe Ala Gly Gly Phe Ala Ala Ala Val Thr Thr Pro Leu 
            100                 105                 110         


Asp Val Ala Lys Thr Arg Ile Thr Leu Ala Lys Ala Gly Ser Ser Thr 
        115                 120                 125             


Ala Asp Gly Asn Val Leu Ser Val Leu His Gly Val Trp Arg Ser Gln 
    130                 135                 140                 


Gly Leu Ala Gly Leu Phe Ala Gly Val Phe Pro Arg Met Ala Ala Ile 
145                 150                 155                 160 


Ser Leu Gly Gly Phe Ile Phe Leu Gly Ala Tyr Asp Arg Thr His Ser 
                165                 170                 175     


Leu Leu Leu Glu Val Gly Arg Lys Ser Pro 
            180                 185     


<210>  2114
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  2114

Met Trp Pro Val Phe Trp Thr Val Val Arg Thr Tyr Ala Pro Tyr Val 
1               5                   10                  15      


Thr Phe Pro Val Ala Phe Val Val Gly Ala Val Gly Tyr His Leu Glu 
            20                  25                  30          


Trp Phe Ile Arg Gly Lys Asp Pro Gln Pro Val Glu Glu Glu Lys Ser 
        35                  40                  45              


Ile Ser Glu Arg Arg Glu Asp Arg Lys Leu Asp Glu Leu Leu Gly Lys 
    50                  55                  60                  


Asp His Thr Gln Val Val Ser Leu Lys Asp Lys Leu Glu Phe Ala Pro 
65                  70                  75                  80  


Lys Ala Val Leu Asn Arg Asn Arg Pro Glu Lys Asn 
                85                  90          


<210>  2115
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  2115

Met Trp Pro Val Phe Trp Thr Val Val Arg Thr Tyr Ala Pro Tyr Val 
1               5                   10                  15      


Thr Phe Pro Val Ala Phe Val Val Gly Ala Val Gly Tyr His Leu Glu 
            20                  25                  30          


Trp Phe Ile Arg Gly Lys Asp Pro Gln Pro Val Glu Glu Glu Lys Ser 
        35                  40                  45              


Ile Ser Glu Arg Arg Glu Asp Arg Lys Leu Asp Glu Leu Leu Gly Lys 
    50                  55                  60                  


Asp His Thr Gln Val Val Ser Leu Lys Asp Lys Leu Glu Phe Ala Pro 
65                  70                  75                  80  


Lys Ala Val Leu Asn Arg Asn Arg Pro Glu Lys Asn 
                85                  90          


<210>  2116
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  2116

Met Asn Glu Thr Asn Lys Thr Leu Val Gly Pro Ser Glu Leu Pro Thr 
1               5                   10                  15      


Ala Ser Ala Val Ala Pro Gly Pro Gly Thr Gly Ala Arg Ala Trp Pro 
            20                  25                  30          


Val Leu Val Gly Phe Val Leu Gly Ala Val Val Leu Ser Leu Leu Ile 
        35                  40                  45              


Ala Leu Ala Ala Lys Cys His Leu Cys Arg Arg Tyr His Ala Ser Tyr 
    50                  55                  60                  


Arg His Arg Pro Leu Pro Glu Thr Gly Arg Gly Gly Arg Pro Gln Val 
65                  70                  75                  80  


Ala Glu Asp Glu Asp Asp Asp Gly Phe Ile Glu Asp Asn Tyr Ile Gln 
                85                  90                  95      


Pro Gly Thr Gly Glu Leu Gly Thr Glu Gly Ser Arg Asp His Phe Ser 
            100                 105                 110         


Leu 
    


<210>  2117
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  2117

Met Glu Leu Val Leu Val Phe Leu Cys Ser Leu Leu Ala Pro Met Val 
1               5                   10                  15      


Leu Ala Ser Ala Ala Glu Lys Glu Lys Glu Met Asp Pro Phe His Tyr 
            20                  25                  30          


Asp Tyr Gln Thr Leu Arg Ile Gly Gly Leu Val Phe Ala Val Val Leu 
        35                  40                  45              


Phe Ser Val Gly Ile Leu Leu Ile Leu Ser Arg Arg Cys Lys Cys Ser 
    50                  55                  60                  


Phe Asn Gln Lys Pro Arg Ala Pro Gly Asp Glu Glu Ala Gln Val Glu 
65                  70                  75                  80  


Asn Leu Ile Thr Ala Asn Ala Thr Glu Pro Gln Lys Ala Glu Asn 
                85                  90                  95  


<210>  2118
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  2118

Met Glu Leu Val Leu Val Phe Leu Cys Ser Leu Leu Ala Pro Met Val 
1               5                   10                  15      


Leu Ala Ser Ala Ala Glu Lys Glu Lys Glu Met Asp Pro Phe His Tyr 
            20                  25                  30          


Asp Tyr Gln Thr Leu Arg Ile Gly Gly Leu Val Phe Ala Val Val Leu 
        35                  40                  45              


Phe Ser Val Gly Ile Leu Leu Ile Leu Ser Arg Arg Cys Lys Cys Ser 
    50                  55                  60                  


Phe Asn Gln Lys Pro Arg Ala Pro Gly Asp Glu Glu Ala Gln Val Glu 
65                  70                  75                  80  


Asn Leu Ile Thr Ala Asn Ala Thr Glu Pro Gln Lys Ala Glu Asn 
                85                  90                  95  


<210>  2119
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  2119

Met Glu Leu Val Leu Val Phe Leu Cys Ser Leu Leu Ala Pro Met Val 
1               5                   10                  15      


Leu Ala Ser Ala Ala Glu Lys Glu Lys Glu Met Asp Pro Phe His Tyr 
            20                  25                  30          


Asp Tyr Gln Thr Leu Arg Ile Gly Gly Leu Val Phe Ala Val Val Leu 
        35                  40                  45              


Phe Ser Val Gly Ile Leu Leu Ile Leu Ser Arg Arg Cys Lys Cys Ser 
    50                  55                  60                  


Phe Asn Gln Lys Pro Arg Ala Pro Gly Asp Glu Glu Ala Gln Val Glu 
65                  70                  75                  80  


Asn Leu Ile Thr Ala Asn Ala Thr Glu Pro Gln Lys Ala Glu Asn 
                85                  90                  95  


<210>  2120
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  2120

Met Glu Leu Val Leu Val Phe Leu Cys Ser Leu Leu Ala Pro Met Val 
1               5                   10                  15      


Leu Ala Ser Ala Ala Glu Lys Glu Lys Glu Met Asp Pro Phe His Tyr 
            20                  25                  30          


Asp Tyr Gln Thr Leu Arg Ile Gly Gly Leu Val Phe Ala Val Val Leu 
        35                  40                  45              


Phe Ser Val Gly Ile Leu Leu Ile Leu Ser Arg Arg Cys Lys Cys Ser 
    50                  55                  60                  


Phe Asn Gln Lys Pro Arg Ala Pro Gly Asp Glu Glu Ala Gln Val Glu 
65                  70                  75                  80  


Asn Leu Ile Thr Ala Asn Ala Thr Glu Pro Gln Lys Ala Glu Asn 
                85                  90                  95  


<210>  2121
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  2121

Met Ala Lys Gly Arg Val Ala Glu Arg Ser Gln Leu Gly Ala His His 
1               5                   10                  15      


Thr Thr Pro Val Gly Asp Gly Ala Ala Gly Thr Arg Gly Leu Ala Ala 
            20                  25                  30          


Pro Gly Ser Arg Asp His Gln Lys Glu Lys Ser Trp Val Glu Ala Gly 
        35                  40                  45              


Ser Ala Arg Met Ser Leu Leu Ile Leu Val Ser Ile Phe Leu Ser Ala 
    50                  55                  60                  


Ala Phe Val Met Phe Leu Val Tyr Lys Asn Phe Pro Gln Leu Ser Glu 
65                  70                  75                  80  


Glu Glu Arg Val Asn Met Lys Val Pro Arg Asp Met Asp Asp Ala Lys 
                85                  90                  95      


Ala Leu Gly Lys Val Leu Ser Lys Tyr Lys Asp Thr Phe Tyr Val Gln 
            100                 105                 110         


Val Leu Val Ala Tyr Phe Ala Thr Tyr Ile Leu Tyr Pro Phe Asn 
        115                 120                 125         


<210>  2122
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  2122

Met Ala Ser Gln Pro Pro Glu Asp Thr Ala Glu Ser Gln Ala Ser Asp 
1               5                   10                  15      


Glu Leu Glu Cys Lys Ile Cys Tyr Asn Arg Tyr Asn Leu Lys Gln Arg 
            20                  25                  30          


Lys Pro Lys Val Leu Glu Cys Cys His Arg Val Cys Ala Lys Cys Leu 
        35                  40                  45              


Tyr Lys Ile Ile Asp Phe Gly Asp Ser Pro Gln Gly Val Ile Val Cys 
    50                  55                  60                  


Pro Phe Cys Arg Phe Glu Thr Cys Leu Pro Asp Asp Glu Val Ser Ser 
65                  70                  75                  80  


Leu Pro Asp Asp Asn Asn Ile Leu Val Asn Leu Thr Cys Gly Gly Lys 
                85                  90                  95      


Gly Lys Lys Cys Leu Pro Glu Asn Pro Thr Glu Leu Leu Leu Thr Pro 
            100                 105                 110         


Lys Arg Leu Ala Ser Leu Val Ser Pro Ser His Thr Ser Ser Asn Cys 
        115                 120                 125             


Leu Val Ile Thr Ile Met Glu Val Gln Arg Glu Ser Ser Pro Ser Leu 
    130                 135                 140                 


Ser Ser Thr Pro Val Val Glu Phe Tyr Arg Pro Ala Ser Phe Asp Ser 
145                 150                 155                 160 


Val Thr Thr Val Ser His Asn Trp Thr Val Trp Asn Cys Thr Ser Leu 
                165                 170                 175     


Leu Phe Gln Thr Ser Ile Arg Val Leu Val Trp Leu Leu Gly Leu Leu 
            180                 185                 190         


Tyr Phe Ser Ser Leu Pro Leu Gly Ile Tyr Leu Leu Val Ser Lys Lys 
        195                 200                 205             


Val Thr Leu Gly Val Val Phe Val Ser Leu Val Pro Ser Ser Leu Val 
    210                 215                 220                 


Ile Leu Met Val Tyr Gly Phe Cys Gln Cys Val Cys His Glu Phe Leu 
225                 230                 235                 240 


Asp Cys Met Ala Pro Pro Ser 
                245         


<210>  2123
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  2123

Met Ala Ser Gln Pro Pro Glu Asp Thr Ala Glu Ser Gln Ala Ser Asp 
1               5                   10                  15      


Glu Leu Glu Cys Lys Ile Cys Tyr Asn Arg Tyr Asn Leu Lys Gln Arg 
            20                  25                  30          


Lys Pro Lys Val Leu Glu Cys Cys His Arg Val Cys Ala Lys Cys Leu 
        35                  40                  45              


Tyr Lys Ile Ile Asp Phe Gly Asp Ser Pro Gln Gly Val Ile Val Cys 
    50                  55                  60                  


Pro Phe Cys Arg Phe Glu Thr Cys Leu Pro Asp Asp Glu Val Ser Ser 
65                  70                  75                  80  


Leu Pro Asp Asp Asn Asn Ile Leu Val Asn Leu Thr Cys Gly Gly Lys 
                85                  90                  95      


Gly Lys Lys Cys Leu Pro Glu Asn Pro Thr Glu Leu Leu Leu Thr Pro 
            100                 105                 110         


Lys Arg Leu Ala Ser Leu Val Ser Pro Ser His Thr Ser Ser Asn Cys 
        115                 120                 125             


Leu Val Ile Thr Ile Met Glu Val Gln Arg Glu Ser Ser Pro Ser Leu 
    130                 135                 140                 


Ser Ser Thr Pro Val Val Glu Phe Tyr Arg Pro Ala Ser Phe Asp Ser 
145                 150                 155                 160 


Val Thr Thr Val Ser His Asn Trp Thr Val Trp Asn Cys Thr Ser Leu 
                165                 170                 175     


Leu Phe Gln Thr Ser Ile Arg Val Leu Val Trp Leu Leu Gly Leu Leu 
            180                 185                 190         


Tyr Phe Ser Ser Leu Pro Leu Gly Ile Tyr Leu Leu Val Ser Lys Lys 
        195                 200                 205             


Val Thr Leu Gly Val Val Phe Val Ser Leu Val Pro Ser Ser Leu Val 
    210                 215                 220                 


Ile Leu Met Val Tyr Gly Phe Cys Gln Cys Val Cys His Glu Phe Leu 
225                 230                 235                 240 


Asp Cys Met Ala Pro Pro Ser 
                245         


<210>  2124
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  2124

Met Ala Ser Gln Pro Pro Glu Asp Thr Ala Glu Ser Gln Ala Ser Asp 
1               5                   10                  15      


Glu Leu Glu Cys Lys Ile Cys Tyr Asn Arg Tyr Asn Leu Lys Gln Arg 
            20                  25                  30          


Lys Pro Lys Val Leu Glu Cys Cys His Arg Val Cys Ala Lys Cys Leu 
        35                  40                  45              


Tyr Lys Ile Ile Asp Phe Gly Asp Ser Pro Gln Gly Val Ile Val Cys 
    50                  55                  60                  


Pro Phe Cys Arg Phe Glu Thr Cys Leu Pro Asp Asp Glu Val Ser Ser 
65                  70                  75                  80  


Leu Pro Asp Asp Asn Asn Ile Leu Val Asn Leu Thr Cys Gly Gly Lys 
                85                  90                  95      


Gly Lys Lys Cys Leu Pro Glu Asn Pro Thr Glu Leu Leu Leu Thr Pro 
            100                 105                 110         


Lys Arg Leu Ala Ser Leu Val Ser Pro Ser His Thr Ser Ser Asn Cys 
        115                 120                 125             


Leu Val Ile Thr Ile Met Glu Val Gln Arg Glu Ser Ser Pro Ser Leu 
    130                 135                 140                 


Ser Ser Thr Pro Val Val Glu Phe Tyr Arg Pro Ala Ser Phe Asp Ser 
145                 150                 155                 160 


Val Thr Thr Val Ser His Asn Trp Thr Val Trp Asn Cys Thr Ser Leu 
                165                 170                 175     


Leu Phe Gln Thr Ser Ile Arg Val Leu Val Trp Leu Leu Gly Leu Leu 
            180                 185                 190         


Tyr Phe Ser Ser Leu Pro Leu Gly Ile Tyr Leu Leu Val Ser Lys Lys 
        195                 200                 205             


Val Thr Leu Gly Val Val Phe Val Ser Leu Val Pro Ser Ser Leu Val 
    210                 215                 220                 


Ile Leu Met Val Tyr Gly Phe Cys Gln Cys Val Cys His Glu Phe Leu 
225                 230                 235                 240 


Asp Cys Met Ala Pro Pro Ser 
                245         


<210>  2125
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  2125

Met Asp Asn Gly Met Phe Ser Gly Phe Ile Met Ile Lys Asn Leu Leu 
1               5                   10                  15      


Leu Phe Cys Ile Ser Met Asn Leu Ser Ser His Phe Gly Phe Ser Gln 
            20                  25                  30          


Met Pro Thr Ser Ser Val Lys Asp Glu Thr Asn Asp Asn Ile Thr Ile 
        35                  40                  45              


Phe Thr Arg Ile Leu Asp Gly Leu Leu Asp Gly Tyr Asp Asn Arg Leu 
    50                  55                  60                  


Arg Pro Gly Leu Gly Glu Arg Ile Thr Gln Val Arg Thr Asp Ile Tyr 
65                  70                  75                  80  


Val Thr Ser Phe Gly Pro Val Ser Asp Thr Glu Met Glu Tyr Thr Ile 
                85                  90                  95      


Asp Val Phe Phe Arg Gln Ser Trp Lys Asp Glu Arg Leu Arg Phe Lys 
            100                 105                 110         


Gly Pro Met Gln Arg Leu Pro Leu Asn Asn Leu Leu Ala Ser Lys Ile 
        115                 120                 125             


Trp Thr Pro Asp Thr Phe Phe His Asn Gly Lys Lys Ser Ile Ala His 
    130                 135                 140                 


Asn Met Thr Thr Pro Asn Lys Leu Leu Arg Leu Glu Asp Asp Gly Thr 
145                 150                 155                 160 


Leu Leu Tyr Thr Met Arg Leu Thr Ile Ser Ala Glu Cys Pro Met Gln 
                165                 170                 175     


Leu Glu Asp Phe Pro Met Asp Ala His Ala Cys Pro Leu Lys Phe Gly 
            180                 185                 190         


Ser Tyr Ala Tyr Pro Asn Ser Glu Val Val Tyr Val Trp Thr Asn Gly 
        195                 200                 205             


Ser Thr Lys Ser Val Val Val Ala Glu Asp Gly Ser Arg Leu Asn Gln 
    210                 215                 220                 


Tyr His Leu Met Gly Gln Thr Val Gly Thr Glu Asn Ile Ser Thr Ser 
225                 230                 235                 240 


Thr Gly Glu Tyr Thr Ile Met Thr Ala His Phe His Leu Lys Arg Lys 
                245                 250                 255     


Ile Gly Tyr Phe Val Ile Gln Thr Tyr Leu Pro Cys Ile Met Thr Val 
            260                 265                 270         


Ile Leu Ser Gln Val Ser Phe Trp Leu Asn Arg Glu Ser Val Pro Ala 
        275                 280                 285             


Arg Thr Val Phe Gly Val Thr Thr Val Leu Thr Met Thr Thr Leu Ser 
    290                 295                 300                 


Ile Ser Ala Arg Asn Ser Leu Pro Lys Val Ala Tyr Ala Thr Ala Met 
305                 310                 315                 320 


Asp Trp Phe Ile Ala Val Cys Tyr Ala Phe Val Phe Ser Ala Leu Ile 
                325                 330                 335     


Glu Phe Ala Thr Val Asn Tyr Phe Thr Lys Arg Gly Trp Ala Trp Asp 
            340                 345                 350         


Gly Lys Lys Ala Leu Glu Ala Ala Lys Ile Lys Lys Lys Arg Glu Val 
        355                 360                 365             


Ile Leu Asn Lys Ser Thr Asn Ala Phe Thr Thr Gly Lys Met Ser His 
    370                 375                 380                 


Pro Pro Asn Ile Pro Lys Glu Gln Thr Pro Ala Gly Thr Ser Asn Thr 
385                 390                 395                 400 


Thr Ser Val Ser Val Lys Pro Ser Glu Glu Lys Thr Ser Glu Ser Lys 
                405                 410                 415     


Lys Thr Tyr Asn Ser Ile Ser Lys Ile Asp Lys Met Ser Arg Ile Val 
            420                 425                 430         


Phe Pro Val Leu Phe Gly Thr Phe Asn Leu Val Tyr Trp Ala Thr Tyr 
        435                 440                 445             


Leu Asn Arg Glu Pro Val Ile Lys Gly Ala Ala Ser Pro Lys 
    450                 455                 460         


<210>  2126
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  2126

Met Gln Asp Thr Gly Ser Val Val Pro Leu His Trp Phe Gly Phe Gly 
1               5                   10                  15      


Tyr Ala Ala Leu Val Ala Ser Gly Gly Ile Ile Gly Tyr Val Lys Ala 
            20                  25                  30          


Gly Ser Val Pro Ser Leu Ala Ala Gly Leu Leu Phe Gly Ser Leu Ala 
        35                  40                  45              


Gly Leu Gly Ala Tyr Gln Leu Ser Gln Asp Pro Arg Asn Val Trp Val 
    50                  55                  60                  


Phe Leu Ala Thr Ser Gly Thr Leu Ala Gly Ile Met Gly Met Arg Phe 
65                  70                  75                  80  


Tyr His Ser Gly Lys Phe Met Pro Ala Gly Leu Ile Ala Gly Ala Ser 
                85                  90                  95      


Leu Leu Met Val Ala Lys Val Gly Val Ser Met Phe Asn Arg Pro His 
            100                 105                 110         


<210>  2127
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  2127

Met Ser Gly Gly Trp Met Ala Gln Val Gly Ala Trp Arg Thr Gly Ala 
1               5                   10                  15      


Leu Gly Leu Ala Leu Leu Leu Leu Leu Gly Leu Gly Leu Gly Leu Glu 
            20                  25                  30          


Ala Ala Ala Ser Pro Leu Ser Thr Pro Thr Ser Ala Gln Ala Ala Gly 
        35                  40                  45              


Ile Glu Pro Cys Thr Gln Lys Gly Gln Cys Pro Pro Pro Pro Gly Leu 
    50                  55                  60                  


Pro Cys Pro Cys Thr Gly Val Ser Asp Cys Ser Gly Gly Thr Asp Lys 
65                  70                  75                  80  


Lys Leu Arg Asn Cys Ser Arg Leu Ala Cys Leu Ala Gly Glu Leu Arg 
                85                  90                  95      


Cys Thr Leu Ser Asp Asp Cys Ile Pro Leu Thr Trp Arg Cys Asp Gly 
            100                 105                 110         


His Pro Asp Cys Pro Asp Ser Ser Asp Glu Leu Gly Cys Gly Thr Asn 
        115                 120                 125             


Glu Ile Leu Pro Glu Gly Asp Ala Thr Thr Met Gly Pro Pro Val Thr 
    130                 135                 140                 


Leu Glu Ser Val Thr Ser Leu Arg Asn Ala Thr Thr Met Gly Pro Pro 
145                 150                 155                 160 


Val Thr Leu Glu Ser Val Pro Ser Val Gly Asn Ala Thr Ser Ser Ser 
                165                 170                 175     


Ala Gly Asp Gln Ser Gly Ser Pro Thr Ala Tyr Gly Val Ile Ala Ala 
            180                 185                 190         


Ala Ala Val Leu Ser Ala Ser Leu Val Thr Ala Thr Leu Leu Leu Leu 
        195                 200                 205             


Ser Trp Leu Arg Ala Gln Glu Arg Leu Arg Pro Leu Gly Leu Leu Val 
    210                 215                 220                 


Ala Met Lys Glu Ser Leu Leu Leu Ser Glu Gln Lys Thr Ser Leu Pro 
225                 230                 235                 240 


<210>  2128
<211>  895
<212>  PRT
<213>  Homo sapiens

<400>  2128

Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Trp Gly Arg 
1               5                   10                  15      


Thr Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro 
            20                  25                  30          


Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu Asn Gln Leu Glu Ala 
        35                  40                  45              


Ser Met His Ser Val Leu Ser Asp Leu His Glu Ala Val Pro Thr Val 
    50                  55                  60                  


Val Gly Ile Pro Asp Gly Thr Ala Val Val Gly Arg Ser Phe Arg Val 
65                  70                  75                  80  


Thr Ile Pro Thr Asp Leu Ile Ala Ser Ser Gly Asp Ile Ile Lys Val 
                85                  90                  95      


Ser Ala Ala Gly Lys Glu Ala Leu Pro Ser Trp Leu His Trp Asp Ser 
            100                 105                 110         


Gln Ser His Thr Leu Glu Gly Leu Pro Leu Asp Thr Asp Lys Gly Val 
        115                 120                 125             


His Tyr Ile Ser Val Ser Ala Thr Arg Leu Gly Ala Asn Gly Ser His 
    130                 135                 140                 


Ile Pro Gln Thr Ser Ser Val Phe Ser Ile Glu Val Tyr Pro Glu Asp 
145                 150                 155                 160 


His Ser Glu Leu Gln Ser Val Arg Thr Ala Ser Pro Asp Pro Gly Glu 
                165                 170                 175     


Val Val Ser Ser Ala Cys Ala Ala Asp Glu Pro Val Thr Val Leu Thr 
            180                 185                 190         


Val Ile Leu Asp Ala Asp Leu Thr Lys Met Thr Pro Lys Gln Arg Ile 
        195                 200                 205             


Asp Leu Leu His Arg Met Arg Ser Phe Ser Glu Val Glu Leu His Asn 
    210                 215                 220                 


Met Lys Leu Val Pro Val Val Asn Asn Arg Leu Phe Asp Met Ser Ala 
225                 230                 235                 240 


Phe Met Ala Gly Pro Gly Asn Ala Lys Lys Val Val Glu Asn Gly Ala 
                245                 250                 255     


Leu Leu Ser Trp Lys Leu Gly Cys Ser Leu Asn Gln Asn Ser Val Pro 
            260                 265                 270         


Asp Ile His Gly Val Glu Ala Pro Ala Arg Glu Gly Ala Met Ser Ala 
        275                 280                 285             


Gln Leu Gly Tyr Pro Val Val Gly Trp His Ile Ala Asn Lys Lys Pro 
    290                 295                 300                 


Pro Leu Pro Lys Arg Val Arg Arg Gln Ile His Ala Thr Pro Thr Pro 
305                 310                 315                 320 


Val Thr Ala Ile Gly Pro Pro Thr Thr Ala Ile Gln Glu Pro Pro Ser 
                325                 330                 335     


Arg Ile Val Pro Thr Pro Thr Ser Pro Ala Ile Ala Pro Pro Thr Glu 
            340                 345                 350         


Thr Met Ala Pro Pro Val Arg Asp Pro Val Pro Gly Lys Pro Thr Val 
        355                 360                 365             


Thr Ile Arg Thr Arg Gly Ala Ile Ile Gln Thr Pro Thr Leu Gly Pro 
    370                 375                 380                 


Ile Gln Pro Thr Arg Val Ser Glu Ala Gly Thr Thr Val Pro Gly Gln 
385                 390                 395                 400 


Ile Arg Pro Thr Met Thr Ile Pro Gly Tyr Val Glu Pro Thr Ala Val 
                405                 410                 415     


Ala Thr Pro Pro Thr Thr Thr Thr Lys Lys Pro Arg Val Ser Thr Pro 
            420                 425                 430         


Lys Pro Ala Thr Pro Ser Thr Asp Ser Thr Thr Thr Thr Thr Arg Arg 
        435                 440                 445             


Pro Thr Lys Lys Pro Arg Thr Pro Arg Pro Val Pro Arg Val Thr Thr 
    450                 455                 460                 


Lys Val Ser Ile Thr Arg Leu Glu Thr Ala Ser Pro Pro Thr Arg Ile 
465                 470                 475                 480 


Arg Thr Thr Thr Ser Gly Val Pro Arg Gly Gly Glu Pro Asn Gln Arg 
                485                 490                 495     


Pro Glu Leu Lys Asn His Ile Asp Arg Val Asp Ala Trp Val Gly Thr 
            500                 505                 510         


Tyr Phe Glu Val Lys Ile Pro Ser Asp Thr Phe Tyr Asp His Glu Asp 
        515                 520                 525             


Thr Thr Thr Asp Lys Leu Lys Leu Thr Leu Lys Leu Arg Glu Gln Gln 
    530                 535                 540                 


Leu Val Gly Glu Lys Ser Trp Val Gln Phe Asn Ser Asn Ser Gln Leu 
545                 550                 555                 560 


Met Tyr Gly Leu Pro Asp Ser Ser His Val Gly Lys His Glu Tyr Phe 
                565                 570                 575     


Met His Ala Thr Asp Lys Gly Gly Leu Ser Ala Val Asp Ala Phe Glu 
            580                 585                 590         


Ile His Val His Arg Arg Pro Gln Gly Asp Arg Ala Pro Ala Arg Phe 
        595                 600                 605             


Lys Ala Lys Phe Val Gly Asp Pro Ala Leu Val Leu Asn Asp Ile His 
    610                 615                 620                 


Lys Lys Ile Ala Leu Val Lys Lys Leu Ala Phe Ala Phe Gly Asp Arg 
625                 630                 635                 640 


Asn Cys Ser Thr Ile Thr Leu Gln Asn Ile Thr Arg Gly Ser Ile Val 
                645                 650                 655     


Val Glu Trp Thr Asn Asn Thr Leu Pro Leu Glu Pro Cys Pro Lys Glu 
            660                 665                 670         


Gln Ile Ala Gly Leu Ser Arg Arg Ile Ala Glu Asp Asp Gly Lys Pro 
        675                 680                 685             


Arg Pro Ala Phe Ser Asn Ala Leu Glu Pro Asp Phe Lys Ala Thr Ser 
    690                 695                 700                 


Ile Thr Val Thr Gly Ser Gly Ser Cys Arg His Leu Gln Phe Ile Pro 
705                 710                 715                 720 


Val Val Pro Pro Arg Arg Val Pro Ser Glu Ala Pro Pro Thr Glu Val 
                725                 730                 735     


Pro Asp Arg Asp Pro Glu Lys Ser Ser Glu Asp Asp Val Tyr Leu His 
            740                 745                 750         


Thr Val Ile Pro Ala Val Val Val Ala Ala Ile Leu Leu Ile Ala Gly 
        755                 760                 765             


Ile Ile Ala Met Ile Cys Tyr Arg Lys Lys Arg Lys Gly Lys Leu Thr 
    770                 775                 780                 


Leu Glu Asp Gln Ala Thr Phe Ile Lys Lys Gly Val Pro Ile Ile Phe 
785                 790                 795                 800 


Ala Asp Glu Leu Asp Asp Ser Lys Pro Pro Pro Ser Ser Ser Met Pro 
                805                 810                 815     


Leu Ile Leu Gln Glu Glu Lys Ala Pro Leu Pro Pro Pro Glu Tyr Pro 
            820                 825                 830         


Asn Gln Ser Val Pro Glu Thr Thr Pro Leu Asn Gln Asp Thr Met Gly 
        835                 840                 845             


Glu Tyr Thr Pro Leu Arg Asp Glu Asp Pro Asn Ala Pro Pro Tyr Gln 
    850                 855                 860                 


Pro Pro Pro Pro Phe Thr Ala Pro Met Glu Gly Lys Gly Ser Arg Pro 
865                 870                 875                 880 


Lys Asn Met Thr Pro Tyr Arg Ser Pro Pro Pro Tyr Val Pro Pro 
                885                 890                 895 


<210>  2129
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  2129

Met Ser Lys Leu Pro Arg Glu Leu Thr Arg Asp Leu Glu Arg Ser Leu 
1               5                   10                  15      


Pro Ala Val Ala Ser Leu Gly Ser Ser Leu Ser His Ser Gln Ser Leu 
            20                  25                  30          


Ser Ser His Leu Leu Pro Pro Pro Glu Lys Arg Arg Ala Ile Ser Asp 
        35                  40                  45              


Val Arg Arg Thr Phe Cys Leu Phe Val Thr Phe Asp Leu Leu Phe Ile 
    50                  55                  60                  


Ser Leu Leu Trp Ile Ile Glu Leu Asn Thr Asn Thr Gly Ile Arg Lys 
65                  70                  75                  80  


Asn Leu Glu Gln Glu Ile Ile Gln Tyr Asn Phe Lys Thr Ser Phe Phe 
                85                  90                  95      


Asp Ile Phe Val Leu Ala Phe Phe Arg Phe Ser Gly Leu Leu Leu Gly 
            100                 105                 110         


Tyr Ala Val Leu Arg Leu Arg His Trp Ser Arg Arg Trp Cys Pro Val 
        115                 120                 125             


His Ser Ser Leu Ser Arg Ser Ser Ser Leu Ser Cys Ser Ala Lys Gly 
    130                 135                 140                 


His Leu Ala Thr Cys Ser Pro Ser Ser Leu Leu Ser Ser Pro Gly Trp 
145                 150                 155                 160 


Arg Pro Gly Ser Leu Thr Ser Lys Ser Tyr Pro Arg Lys Leu Lys Arg 
                165                 170                 175     


Ser Asp Ser Ala Pro Pro Gly Tyr Leu Ala Ala Gln Val Ala Val Ala 
            180                 185                 190         


Arg Gly Pro Leu Leu Phe Ser Gly Ala Leu Ser Glu Gly Gln Phe Tyr 
        195                 200                 205             


Ser Pro Pro Glu Ser Phe Ala Gly Ser Asp Asn Glu Ser Asp Glu Glu 
    210                 215                 220                 


Val Ala Gly Lys Lys Ser Phe Ser Ala Gln Glu Arg Glu Tyr Ile Arg 
225                 230                 235                 240 


Gln Gly Lys Glu Ala Thr Ala Val Val Asp Gln Ile Leu Ala Gln Glu 
                245                 250                 255     


Glu Asn Trp Lys Phe Glu Lys Asn Asn Glu Tyr Gly Asp Thr Val Tyr 
            260                 265                 270         


Thr Ile Glu Val Pro Phe His Gly Lys Thr Phe Ile Leu Lys Thr Phe 
        275                 280                 285             


Leu Pro Cys Pro Ala Glu Leu Val Tyr Gln Glu Val Ile Leu Gln Pro 
    290                 295                 300                 


Glu Arg Met Val Leu Trp Asn Lys Thr Val Thr Ala Cys Gln Ile Leu 
305                 310                 315                 320 


Gln Arg Val Glu Asp Asn Thr Leu Ile Ser Tyr Asp Val Ser Ala Gly 
                325                 330                 335     


Ala Ala Gly Gly Val Val Ser Pro Arg Asp Phe Val Asn Val Arg Arg 
            340                 345                 350         


Ile Glu Arg Arg Arg Asp Arg Tyr Leu Ser Ser Gly Ile Ala Thr Ser 
        355                 360                 365             


His Ser Ala Lys Pro Pro Thr His Lys Tyr Val Arg Gly Glu Asn Gly 
    370                 375                 380                 


Pro Gly Gly Phe Ile Val Leu Lys Ser Ala Ser Asn Pro Arg Val Cys 
385                 390                 395                 400 


Thr Phe Val Trp Ile Leu Asn Thr Asp Leu Lys Gly Arg Leu Pro Arg 
                405                 410                 415     


Tyr Leu Ile His Gln Ser Leu Ala Ala Thr Met Phe Glu Phe Ala Phe 
            420                 425                 430         


His Leu Arg Gln Arg Ile Ser Glu Leu Gly Ala Arg Ala 
        435                 440                 445 


<210>  2130
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  2130

Met Ser Lys Leu Pro Arg Glu Leu Thr Arg Asp Leu Glu Arg Ser Leu 
1               5                   10                  15      


Pro Ala Val Ala Ser Leu Gly Ser Ser Leu Ser His Ser Gln Ser Leu 
            20                  25                  30          


Ser Ser His Leu Leu Pro Pro Pro Glu Lys Arg Arg Ala Ile Ser Asp 
        35                  40                  45              


Val Arg Arg Thr Phe Cys Leu Phe Val Thr Phe Asp Leu Leu Phe Ile 
    50                  55                  60                  


Ser Leu Leu Trp Ile Ile Glu Leu Asn Thr Asn Thr Gly Ile Arg Lys 
65                  70                  75                  80  


Asn Leu Glu Gln Glu Ile Ile Gln Tyr Asn Phe Lys Thr Ser Phe Phe 
                85                  90                  95      


Asp Ile Phe Val Leu Ala Phe Phe Arg Phe Ser Gly Leu Leu Leu Gly 
            100                 105                 110         


Tyr Ala Val Leu Arg Leu Arg His Trp Trp Val Ile Ala Leu Leu Ser 
        115                 120                 125             


Lys Gly Ala Phe Gly Tyr Leu Leu Pro Ile Val Ser Phe Val Leu Ala 
    130                 135                 140                 


Trp Leu Glu Thr Trp Phe Leu Asp Phe Lys Val Leu Pro Gln Glu Ala 
145                 150                 155                 160 


Glu Glu Glu Arg Trp Tyr Leu Ala Ala Gln Val Ala Val Ala Arg Gly 
                165                 170                 175     


Pro Leu Leu Phe Ser Gly Ala Leu Ser Glu Gly Gln Phe Tyr Ser Pro 
            180                 185                 190         


Pro Glu Ser Phe Ala Gly Ser Asp Asn Glu Ser Asp Glu Glu Val Ala 
        195                 200                 205             


Gly Lys Lys Ser Phe Ser Ala Gln Glu Arg Glu Tyr Ile Arg Gln Gly 
    210                 215                 220                 


Lys Glu Ala Thr Ala Val Val Asp Gln Ile Leu Ala Gln Glu Glu Asn 
225                 230                 235                 240 


Trp Lys Phe Glu Lys Asn Asn Glu Tyr Gly Asp Thr Val Tyr Thr Ile 
                245                 250                 255     


Glu Val Pro Phe His Gly Lys Thr Phe Ile Leu Lys Thr Phe Leu Pro 
            260                 265                 270         


Cys Pro Ala Glu Leu Val Tyr Gln Glu Val Ile Leu Gln Pro Glu Arg 
        275                 280                 285             


Met Val Leu Trp Asn Lys Thr Val Thr Ala Cys Gln Ile Leu Gln Arg 
    290                 295                 300                 


Val Glu Asp Asn Thr Leu Ile Ser Tyr Asp Val Ser Ala Gly Ala Ala 
305                 310                 315                 320 


Gly Gly Val Val Ser Pro Arg Asp Phe Val Asn Val Arg Arg Ile Glu 
                325                 330                 335     


Arg Arg Arg Asp Arg Tyr Leu Ser Ser Gly Ile Ala Thr Ser His Ser 
            340                 345                 350         


Ala Lys Pro Pro Thr His Lys Tyr Val Arg Gly Glu Asn Gly Pro Gly 
        355                 360                 365             


Gly Phe Ile Val Leu Lys Ser Ala Ser Asn Pro Arg Val Cys Thr Phe 
    370                 375                 380                 


Val Trp Ile Leu Asn Thr Asp Leu Lys Gly Arg Leu Pro Arg Tyr Leu 
385                 390                 395                 400 


Ile His Gln Ser Leu Ala Ala Thr Met Phe Glu Phe Ala Phe His Leu 
                405                 410                 415     


Arg Gln Arg Ile Ser Glu Leu Gly Ala Arg Ala 
            420                 425         


<210>  2131
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  2131

Met Pro Cys Pro Pro Leu Leu Ser Val Pro Val Arg Ala Ala Gly Glu 
1               5                   10                  15      


Gln Asp Arg Trp Val Arg Glu Glu Val Thr Trp Gly Gly Gly Pro Thr 
            20                  25                  30          


Val Thr Gly Gly Trp Gly Trp Arg Ala His Leu Arg Ser Val Ser Pro 
        35                  40                  45              


Pro Gly Val Leu Phe Ser Ile Glu Val Met Ser Ser His Phe Ser Val 
    50                  55                  60                  


Trp Asp Tyr Trp Arg Gly Phe Phe Ala Ala Thr Cys Gly Ala Phe Met 
65                  70                  75                  80  


Phe Arg Leu Leu Ala Val Phe Asn Ser Glu Gln Glu Thr Ile Thr Ser 
                85                  90                  95      


Leu Tyr Lys Thr Ser Phe Arg Val Asp Val Pro Phe Asp Leu Pro Glu 
            100                 105                 110         


Ile Phe Phe Phe Val Ala Leu Gly Gly Leu Cys Gly Ile Leu Gly Ser 
        115                 120                 125             


Ala Tyr Leu Phe Cys Gln Arg Ile Phe Phe Gly Phe Ile Arg Asn Asn 
    130                 135                 140                 


Arg Phe Ser Ser Lys Leu Leu Ala Thr Ser Lys Pro Val Tyr Ser Ala 
145                 150                 155                 160 


Leu Ala Thr Leu Val Leu Ala Ser Ile Thr Tyr Pro Pro Ser Ala Gly 
                165                 170                 175     


Arg Phe Leu Ala Ser Arg Leu Ser Met Lys Gln His Leu Asp Ser Leu 
            180                 185                 190         


Phe Asp Asn His Ser Trp Ala Leu Met Thr Gln Asn Ser Ser Pro Pro 
        195                 200                 205             


Trp Pro Glu Glu Leu Asp Pro Gln His Leu Trp Trp Glu Trp Tyr His 
    210                 215                 220                 


Pro Arg Phe Thr Ile Phe Gly Thr Leu Ala Phe Phe Leu Val Met Lys 
225                 230                 235                 240 


Phe Trp Met Leu Ile Leu Ala Thr Thr Ile Pro Met Pro Ala Gly Tyr 
                245                 250                 255     


Phe Met Pro Ile Phe Val Tyr Gly Ala Ala Ile Gly Arg Leu Phe Gly 
            260                 265                 270         


Glu Thr Leu Ser Phe Ile Phe Pro Glu Gly Ile Val Ala Gly Gly Ile 
        275                 280                 285             


Thr Asn Pro Ile Met Pro Gly Gly Tyr Ala Leu Ala Gly Ala Ala Ala 
    290                 295                 300                 


Phe Ser Gly Ala Val Thr His Thr Ile Ser Thr Ala Leu Leu Ala Phe 
305                 310                 315                 320 


Glu Val Thr Gly Gln Ile Val His Ala Leu Pro Val Leu Met Ala Val 
                325                 330                 335     


Leu Ala Ala Asn Ala Ile Ala Gln Ser Cys Gln Pro Ser Phe Tyr Asp 
            340                 345                 350         


Gly Thr Val Ile Val Lys Lys Leu Pro Tyr Leu Pro Arg Ile Leu Gly 
        355                 360                 365             


Arg Asn Ile Gly Ser His Arg Val Arg Val Glu His Phe Met Asn His 
    370                 375                 380                 


Ser Ile Thr Thr Leu Ala Lys Asp Met Pro Leu Glu Glu Val Val Lys 
385                 390                 395                 400 


Val Val Thr Ser Thr Asp Val Ala Lys Tyr Pro Leu Val Glu Ser Thr 
                405                 410                 415     


Glu Ser Gln Ile Leu Val Gly Ile Val Arg Arg Ala Gln Leu Val Gln 
            420                 425                 430         


Ala Leu Lys Ala Glu Pro Pro Ser Trp Ala Pro Gly His Gln Cys Leu 
        435                 440                 445             


Gln Asp Ile Leu Ala Ala Gly Cys Pro Thr Glu Pro Val Thr Leu Lys 
    450                 455                 460                 


Leu Ser Pro Glu Thr Ser Leu His Glu Ala His Asn Leu Phe Glu Leu 
465                 470                 475                 480 


Leu Asn Leu His Ser Leu Phe Val Thr Ser Arg Gly Arg Ala Val Gly 
                485                 490                 495     


Cys Val Ser Trp Val Glu Met Lys Lys Ala Ile Ser Asn Leu Thr Asn 
            500                 505                 510         


Pro Pro Ala Pro Lys 
        515         


<210>  2132
<211>  387
<212>  PRT
<213>  Homo sapiens

<400>  2132

Met Gln Phe Leu Lys Ser Ala Lys Gln Lys Pro Asn Tyr Tyr His Ile 
1               5                   10                  15      


Met Leu Val Glu Asp Gln Glu Glu Gly Thr Leu His Gln Phe Asn Tyr 
            20                  25                  30          


Cys Glu Arg Cys Ser Glu Ser Gln Asn Asn Lys Cys Ile Ser Cys Val 
        35                  40                  45              


Asp Pro Glu Asp Lys Trp Tyr Arg Trp Pro Leu Pro Ser Lys Leu Cys 
    50                  55                  60                  


Ala Val Trp Ile Tyr Leu Asp Val Leu Phe Ser Thr Ala Ser Ile Met 
65                  70                  75                  80  


His Leu Cys Ala Ile Ser Leu Asp Arg Tyr Val Ala Ile Gln Asn Pro 
                85                  90                  95      


Ile His His Ser Arg Phe Asn Ser Arg Thr Lys Ala Phe Leu Lys Ile 
            100                 105                 110         


Ile Ala Val Trp Thr Ile Ser Val Gly Ile Ser Met Pro Ile Pro Val 
        115                 120                 125             


Phe Gly Leu Gln Asp Asp Ser Lys Val Phe Lys Glu Gly Ser Cys Leu 
    130                 135                 140                 


Leu Ala Asp Asp Asn Phe Val Leu Ile Gly Ser Phe Val Ser Phe Phe 
145                 150                 155                 160 


Ile Pro Leu Thr Ile Met Val Ile Thr Tyr Phe Leu Thr Ile Lys Ser 
                165                 170                 175     


Leu Gln Lys Glu Ala Thr Leu Cys Val Ser Asp Leu Gly Thr Arg Ala 
            180                 185                 190         


Lys Leu Ala Ser Phe Ser Phe Leu Pro Gln Ser Ser Leu Ser Ser Glu 
        195                 200                 205             


Lys Leu Phe Gln Arg Ser Ile His Arg Glu Pro Gly Ser Tyr Thr Gly 
    210                 215                 220                 


Arg Arg Thr Met Gln Ser Ile Ser Asn Glu Gln Lys Ala Cys Lys Val 
225                 230                 235                 240 


Leu Gly Ile Val Phe Phe Leu Phe Val Val Met Trp Cys Pro Phe Phe 
                245                 250                 255     


Ile Thr Asn Ile Met Ala Val Ile Cys Lys Glu Ser Cys Asn Glu Asp 
            260                 265                 270         


Val Ile Gly Ala Leu Leu Asn Val Phe Val Trp Ile Gly Tyr Leu Ser 
        275                 280                 285             


Ser Ala Val Asn Pro Leu Val Tyr Thr Leu Phe Asn Lys Thr Tyr Arg 
    290                 295                 300                 


Ser Ala Phe Ser Arg Tyr Ile Gln Cys Gln Tyr Lys Glu Asn Lys Lys 
305                 310                 315                 320 


Pro Leu Gln Leu Ile Leu Val Asn Thr Ile Pro Ala Leu Ala Tyr Lys 
                325                 330                 335     


Ser Ser Gln Leu Gln Met Gly Gln Lys Lys Asn Ser Lys Gln Asp Ala 
            340                 345                 350         


Lys Thr Thr Asp Asn Asp Cys Ser Met Val Ala Leu Gly Lys Gln His 
        355                 360                 365             


Ser Glu Glu Ala Ser Lys Asp Asn Ser Asp Gly Val Asn Glu Lys Val 
    370                 375                 380                 


Ser Cys Val 
385         


<210>  2133
<211>  2009
<212>  PRT
<213>  Homo sapiens

<400>  2133

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Gly 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn Glu 
        995                 1000                 1005             


Met Asn  Asn Leu Gln Ile Ala  Val Asp Arg Met His  Lys Gly Val 
    1010                 1015                 1020             


Ala Tyr  Val Lys Arg Lys Ile  Tyr Glu Phe Ile Gln  Gln Ser Phe 
    1025                 1030                 1035             


Ile Arg  Lys Gln Lys Ile Leu  Asp Glu Ile Lys Pro  Leu Asp Asp 
    1040                 1045                 1050             


Leu Asn  Asn Lys Lys Asp Ser  Cys Met Ser Asn His  Thr Ala Glu 
    1055                 1060                 1065             


Ile Gly  Lys Asp Leu Asp Tyr  Leu Lys Asp Val Asn  Gly Thr Thr 
    1070                 1075                 1080             


Ser Gly  Ile Gly Thr Gly Ser  Ser Val Glu Lys Tyr  Ile Ile Asp 
    1085                 1090                 1095             


Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn Pro Ser  Leu Thr Val 
    1100                 1105                 1110             


Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp Phe Glu  Asn Leu Asn 
    1115                 1120                 1125             


Thr Glu  Asp Phe Ser Ser Glu  Ser Asp Leu Glu Glu  Ser Lys Glu 
    1130                 1135                 1140             


Lys Leu  Asn Glu Ser Ser Ser  Ser Ser Glu Gly Ser  Thr Val Asp 
    1145                 1150                 1155             


Ile Gly  Ala Pro Val Glu Glu  Gln Pro Val Val Glu  Pro Glu Glu 
    1160                 1165                 1170             


Thr Leu  Glu Pro Glu Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg 
    1175                 1180                 1185             


Phe Lys  Cys Cys Gln Ile Asn  Val Glu Glu Gly Arg  Gly Lys Gln 
    1190                 1195                 1200             


Trp Trp  Asn Leu Arg Arg Thr  Cys Phe Arg Ile Val  Glu His Asn 
    1205                 1210                 1215             


Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile Leu Leu  Ser Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Asp Gln Arg  Lys Thr Ile 
    1235                 1240                 1245             


Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe 
    1250                 1255                 1260             


Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala Tyr Gly  Tyr Gln Thr 
    1265                 1270                 1275             


Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp Phe Leu  Ile Val Asp 
    1280                 1285                 1290             


Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala Leu Gly  Tyr Ser Glu 
    1295                 1300                 1305             


Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro 
    1310                 1315                 1320             


Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met Arg Val  Val Val Asn 
    1325                 1330                 1335             


Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met Asn Val  Leu Leu Val 
    1340                 1345                 1350             


Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu 
    1355                 1360                 1365             


Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn Thr Thr  Thr Gly Asp 
    1370                 1375                 1380             


Arg Phe  Asp Ile Glu Asp Val  Asn Asn His Thr Asp  Cys Leu Lys 
    1385                 1390                 1395             


Leu Ile  Glu Arg Asn Glu Thr  Ala Arg Trp Lys Asn  Val Lys Val 
    1400                 1405                 1410             


Asn Phe  Asp Asn Val Gly Phe  Gly Tyr Leu Ser Leu  Leu Gln Val 
    1415                 1420                 1425             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1430                 1435                 1440             


Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr Glu Glu  Ser Leu Tyr 
    1445                 1450                 1455             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1460                 1465                 1470             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1475                 1480                 1485             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1490                 1495                 1500             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1505                 1510                 1515             


Pro Gln  Lys Pro Ile Pro Arg  Pro Gly Asn Lys Phe  Gln Gly Met 
    1520                 1525                 1530             


Val Phe  Asp Phe Val Thr Arg  Gln Val Phe Asp Ile  Ser Ile Met 
    1535                 1540                 1545             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1550                 1555                 1560             


Asp Gln  Ser Glu Tyr Val Thr  Thr Ile Leu Ser Arg  Ile Asn Leu 
    1565                 1570                 1575             


Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys Val Leu  Lys Leu Ile 
    1580                 1585                 1590             


Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1595                 1600                 1605             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Met Phe  Leu Ala Glu 
    1610                 1615                 1620             


Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Arg Val Ile 
    1625                 1630                 1635             


Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg Leu Ile  Lys Gly Ala 
    1640                 1645                 1650             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1655                 1660                 1665             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1670                 1675                 1680             


Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Arg Glu 
    1685                 1690                 1695             


Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu Thr Phe  Gly Asn Ser 
    1700                 1705                 1710             


Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1715                 1720                 1725             


Leu Leu  Ala Pro Ile Leu Asn  Ser Lys Pro Pro Asp  Cys Asp Pro 
    1730                 1735                 1740             


Asn Lys  Val Asn Pro Gly Ser  Ser Val Lys Gly Asp  Cys Gly Asn 
    1745                 1750                 1755             


Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser 
    1760                 1765                 1770             


Phe Leu  Val Val Val Asn Met  Tyr Ile Ala Val Ile  Leu Glu Asn 
    1775                 1780                 1785             


Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu Pro Leu  Ser Glu Asp 
    1790                 1795                 1800             


Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu Lys Phe  Asp Pro Asp 
    1805                 1810                 1815             


Ala Thr  Gln Phe Met Glu Phe  Glu Lys Leu Ser Gln  Phe Ala Ala 
    1820                 1825                 1830             


Ala Leu  Glu Pro Pro Leu Asn  Leu Pro Gln Pro Asn  Lys Leu Gln 
    1835                 1840                 1845             


Leu Ile  Ala Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1850                 1855                 1860             


Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1865                 1870                 1875             


Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln Met Glu  Glu Arg Phe 
    1880                 1885                 1890             


Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr Gln Pro  Ile Thr Thr 
    1895                 1900                 1905             


Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser Ala Val  Ile Ile Gln 
    1910                 1915                 1920             


Arg Ala  Tyr Arg Arg His Leu  Leu Lys Arg Thr Val  Lys Gln Ala 
    1925                 1930                 1935             


Ser Phe  Thr Tyr Asn Lys Asn  Lys Ile Lys Gly Gly  Ala Asn Leu 
    1940                 1945                 1950             


Leu Ile  Lys Glu Asp Met Ile  Ile Asp Arg Ile Asn  Glu Asn Ser 
    1955                 1960                 1965             


Ile Thr  Glu Lys Thr Asp Leu  Thr Met Ser Thr Ala  Ala Cys Pro 
    1970                 1975                 1980             


Pro Ser  Tyr Asp Arg Val Thr  Lys Pro Ile Val Glu  Lys His Glu 
    1985                 1990                 1995             


Gln Glu  Gly Lys Asp Glu Lys  Ala Lys Gly Lys 
    2000                 2005                 


<210>  2134
<211>  1981
<212>  PRT
<213>  Homo sapiens

<400>  2134

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Gly 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Gly Thr Thr 
                645                 650                 655     


Thr Glu Thr Glu Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser 
            660                 665                 670         


Met Asp Phe Leu Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile 
        675                 680                 685             


Ala Ser Ile Leu Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln 
    690                 695                 700                 


Lys Cys Pro Pro Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp 
705                 710                 715                 720 


Asp Cys Ser Pro Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val 
                725                 730                 735     


Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu 
            740                 745                 750         


Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe 
        755                 760                 765             


Asn Asn Val Leu Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr 
    770                 775                 780                 


Ala Glu Met Phe Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe 
785                 790                 795                 800 


Gln Glu Gly Trp Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu 
                805                 810                 815     


Val Glu Leu Gly Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser 
            820                 825                 830         


Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu 
        835                 840                 845             


Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn 
    850                 855                 860                 


Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly 
865                 870                 875                 880 


Met Gln Leu Phe Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala 
                885                 890                 895     


Ser Asp Cys Gln Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser 
            900                 905                 910         


Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met 
        915                 920                 925             


Trp Asp Cys Met Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe 
    930                 935                 940                 


Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu 
945                 950                 955                 960 


Ala Leu Leu Leu Ser Ser Phe Ser Ala Asp Asn Leu Ala Ala Thr Asp 
                965                 970                 975     


Asp Asp Asn Glu Met Asn Asn Leu Gln Ile Ala Val Asp Arg Met His 
            980                 985                 990         


Lys Gly Val Ala Tyr Val Lys Arg  Lys Ile Tyr Glu Phe  Ile Gln Gln 
        995                 1000                 1005             


Ser Phe  Ile Arg Lys Gln Lys  Ile Leu Asp Glu Ile  Lys Pro Leu 
    1010                 1015                 1020             


Asp Asp  Leu Asn Asn Lys Lys  Asp Ser Cys Met Ser  Asn His Thr 
    1025                 1030                 1035             


Ala Glu  Ile Gly Lys Asp Leu  Asp Tyr Leu Lys Asp  Val Asn Gly 
    1040                 1045                 1050             


Thr Thr  Ser Gly Ile Gly Thr  Gly Ser Ser Val Glu  Lys Tyr Ile 
    1055                 1060                 1065             


Ile Asp  Glu Ser Asp Tyr Met  Ser Phe Ile Asn Asn  Pro Ser Leu 
    1070                 1075                 1080             


Thr Val  Thr Val Pro Ile Ala  Val Gly Glu Ser Asp  Phe Glu Asn 
    1085                 1090                 1095             


Leu Asn  Thr Glu Asp Phe Ser  Ser Glu Ser Asp Leu  Glu Glu Ser 
    1100                 1105                 1110             


Lys Glu  Lys Leu Asn Glu Ser  Ser Ser Ser Ser Glu  Gly Ser Thr 
    1115                 1120                 1125             


Val Asp  Ile Gly Ala Pro Val  Glu Glu Gln Pro Val  Val Glu Pro 
    1130                 1135                 1140             


Glu Glu  Thr Leu Glu Pro Glu  Ala Cys Phe Thr Glu  Gly Cys Val 
    1145                 1150                 1155             


Gln Arg  Phe Lys Cys Cys Gln  Ile Asn Val Glu Glu  Gly Arg Gly 
    1160                 1165                 1170             


Lys Gln  Trp Trp Asn Leu Arg  Arg Thr Cys Phe Arg  Ile Val Glu 
    1175                 1180                 1185             


His Asn  Trp Phe Glu Thr Phe  Ile Val Phe Met Ile  Leu Leu Ser 
    1190                 1195                 1200             


Ser Gly  Ala Leu Ala Phe Glu  Asp Ile Tyr Ile Asp  Gln Arg Lys 
    1205                 1210                 1215             


Thr Ile  Lys Thr Met Leu Glu  Tyr Ala Asp Lys Val  Phe Thr Tyr 
    1220                 1225                 1230             


Ile Phe  Ile Leu Glu Met Leu  Leu Lys Trp Val Ala  Tyr Gly Tyr 
    1235                 1240                 1245             


Gln Thr  Tyr Phe Thr Asn Ala  Trp Cys Trp Leu Asp  Phe Leu Ile 
    1250                 1255                 1260             


Val Asp  Val Ser Leu Val Ser  Leu Thr Ala Asn Ala  Leu Gly Tyr 
    1265                 1270                 1275             


Ser Glu  Leu Gly Ala Ile Lys  Ser Leu Arg Thr Leu  Arg Ala Leu 
    1280                 1285                 1290             


Arg Pro  Leu Arg Ala Leu Ser  Arg Phe Glu Gly Met  Arg Val Val 
    1295                 1300                 1305             


Val Asn  Ala Leu Leu Gly Ala  Ile Pro Ser Ile Met  Asn Val Leu 
    1310                 1315                 1320             


Leu Val  Cys Leu Ile Phe Trp  Leu Ile Phe Ser Ile  Met Gly Val 
    1325                 1330                 1335             


Asn Leu  Phe Ala Gly Lys Phe  Tyr His Cys Ile Asn  Thr Thr Thr 
    1340                 1345                 1350             


Gly Asp  Arg Phe Asp Ile Glu  Asp Val Asn Asn His  Thr Asp Cys 
    1355                 1360                 1365             


Leu Lys  Leu Ile Glu Arg Asn  Glu Thr Ala Arg Trp  Lys Asn Val 
    1370                 1375                 1380             


Lys Val  Asn Phe Asp Asn Val  Gly Phe Gly Tyr Leu  Ser Leu Leu 
    1385                 1390                 1395             


Gln Val  Ala Thr Phe Lys Gly  Trp Met Asp Ile Met  Tyr Ala Ala 
    1400                 1405                 1410             


Val Asp  Ser Arg Asn Val Glu  Leu Gln Pro Lys Tyr  Glu Glu Ser 
    1415                 1420                 1425             


Leu Tyr  Met Tyr Leu Tyr Phe  Val Ile Phe Ile Ile  Phe Gly Ser 
    1430                 1435                 1440             


Phe Phe  Thr Leu Asn Leu Phe  Ile Gly Val Ile Ile  Asp Asn Phe 
    1445                 1450                 1455             


Asn Gln  Gln Lys Lys Lys Phe  Gly Gly Gln Asp Ile  Phe Met Thr 
    1460                 1465                 1470             


Glu Glu  Gln Lys Lys Tyr Tyr  Asn Ala Met Lys Lys  Leu Gly Ser 
    1475                 1480                 1485             


Lys Lys  Pro Gln Lys Pro Ile  Pro Arg Pro Gly Asn  Lys Phe Gln 
    1490                 1495                 1500             


Gly Met  Val Phe Asp Phe Val  Thr Arg Gln Val Phe  Asp Ile Ser 
    1505                 1510                 1515             


Ile Met  Ile Leu Ile Cys Leu  Asn Met Val Thr Met  Met Val Glu 
    1520                 1525                 1530             


Thr Asp  Asp Gln Ser Glu Tyr  Val Thr Thr Ile Leu  Ser Arg Ile 
    1535                 1540                 1545             


Asn Leu  Val Phe Ile Val Leu  Phe Thr Gly Glu Cys  Val Leu Lys 
    1550                 1555                 1560             


Leu Ile  Ser Leu Arg His Tyr  Tyr Phe Thr Ile Gly  Trp Asn Ile 
    1565                 1570                 1575             


Phe Asp  Phe Val Val Val Ile  Leu Ser Ile Val Gly  Met Phe Leu 
    1580                 1585                 1590             


Ala Glu  Leu Ile Glu Lys Tyr  Phe Val Ser Pro Thr  Leu Phe Arg 
    1595                 1600                 1605             


Val Ile  Arg Leu Ala Arg Ile  Gly Arg Ile Leu Arg  Leu Ile Lys 
    1610                 1615                 1620             


Gly Ala  Lys Gly Ile Arg Thr  Leu Leu Phe Ala Leu  Met Met Ser 
    1625                 1630                 1635             


Leu Pro  Ala Leu Phe Asn Ile  Gly Leu Leu Leu Phe  Leu Val Met 
    1640                 1645                 1650             


Phe Ile  Tyr Ala Ile Phe Gly  Met Ser Asn Phe Ala  Tyr Val Lys 
    1655                 1660                 1665             


Arg Glu  Val Gly Ile Asp Asp  Met Phe Asn Phe Glu  Thr Phe Gly 
    1670                 1675                 1680             


Asn Ser  Met Ile Cys Leu Phe  Gln Ile Thr Thr Ser  Ala Gly Trp 
    1685                 1690                 1695             


Asp Gly  Leu Leu Ala Pro Ile  Leu Asn Ser Lys Pro  Pro Asp Cys 
    1700                 1705                 1710             


Asp Pro  Asn Lys Val Asn Pro  Gly Ser Ser Val Lys  Gly Asp Cys 
    1715                 1720                 1725             


Gly Asn  Pro Ser Val Gly Ile  Phe Phe Phe Val Ser  Tyr Ile Ile 
    1730                 1735                 1740             


Ile Ser  Phe Leu Val Val Val  Asn Met Tyr Ile Ala  Val Ile Leu 
    1745                 1750                 1755             


Glu Asn  Phe Ser Val Ala Thr  Glu Glu Ser Ala Glu  Pro Leu Ser 
    1760                 1765                 1770             


Glu Asp  Asp Phe Glu Met Phe  Tyr Glu Val Trp Glu  Lys Phe Asp 
    1775                 1780                 1785             


Pro Asp  Ala Thr Gln Phe Met  Glu Phe Glu Lys Leu  Ser Gln Phe 
    1790                 1795                 1800             


Ala Ala  Ala Leu Glu Pro Pro  Leu Asn Leu Pro Gln  Pro Asn Lys 
    1805                 1810                 1815             


Leu Gln  Leu Ile Ala Met Asp  Leu Pro Met Val Ser  Gly Asp Arg 
    1820                 1825                 1830             


Ile His  Cys Leu Asp Ile Leu  Phe Ala Phe Thr Lys  Arg Val Leu 
    1835                 1840                 1845             


Gly Glu  Ser Gly Glu Met Asp  Ala Leu Arg Ile Gln  Met Glu Glu 
    1850                 1855                 1860             


Arg Phe  Met Ala Ser Asn Pro  Ser Lys Val Ser Tyr  Gln Pro Ile 
    1865                 1870                 1875             


Thr Thr  Thr Leu Lys Arg Lys  Gln Glu Glu Val Ser  Ala Val Ile 
    1880                 1885                 1890             


Ile Gln  Arg Ala Tyr Arg Arg  His Leu Leu Lys Arg  Thr Val Lys 
    1895                 1900                 1905             


Gln Ala  Ser Phe Thr Tyr Asn  Lys Asn Lys Ile Lys  Gly Gly Ala 
    1910                 1915                 1920             


Asn Leu  Leu Ile Lys Glu Asp  Met Ile Ile Asp Arg  Ile Asn Glu 
    1925                 1930                 1935             


Asn Ser  Ile Thr Glu Lys Thr  Asp Leu Thr Met Ser  Thr Ala Ala 
    1940                 1945                 1950             


Cys Pro  Pro Ser Tyr Asp Arg  Val Thr Lys Pro Ile  Val Glu Lys 
    1955                 1960                 1965             


His Glu  Gln Glu Gly Lys Asp  Glu Lys Ala Lys Gly  Lys 
    1970                 1975                 1980     


<210>  2135
<211>  695
<212>  PRT
<213>  Homo sapiens

<400>  2135

Met Ser Glu Gly Ala Ala Ala Ala Ser Pro Pro Gly Ala Ala Ser Ala 
1               5                   10                  15      


Ala Ala Ala Ser Ala Glu Glu Gly Thr Ala Ala Ala Ala Ala Ala Ala 
            20                  25                  30          


Ala Ala Gly Gly Gly Pro Asp Gly Gly Gly Glu Gly Ala Ala Glu Pro 
        35                  40                  45              


Pro Arg Glu Leu Arg Cys Ser Asp Cys Ile Val Trp Asn Arg Gln Gln 
    50                  55                  60                  


Thr Trp Leu Cys Val Val Pro Leu Phe Ile Gly Phe Ile Gly Leu Gly 
65                  70                  75                  80  


Leu Ser Leu Met Leu Leu Lys Trp Ile Val Val Gly Ser Val Lys Glu 
                85                  90                  95      


Tyr Val Pro Thr Asp Leu Val Asp Ser Lys Gly Met Gly Gln Asp Pro 
            100                 105                 110         


Phe Phe Leu Ser Lys Pro Ser Ser Phe Pro Lys Ala Met Glu Thr Thr 
        115                 120                 125             


Thr Thr Thr Thr Ser Thr Thr Ser Pro Ala Thr Pro Ser Ala Gly Gly 
    130                 135                 140                 


Ala Ala Ser Ser Arg Thr Pro Asn Arg Ile Ser Thr Arg Leu Thr Thr 
145                 150                 155                 160 


Ile Thr Arg Ala Pro Thr Arg Phe Pro Gly His Arg Val Pro Ile Arg 
                165                 170                 175     


Ala Ser Pro Arg Ser Thr Thr Ala Arg Asn Thr Ala Ala Pro Ala Thr 
            180                 185                 190         


Val Pro Ser Thr Thr Ala Pro Phe Phe Ser Ser Ser Thr Leu Gly Ser 
        195                 200                 205             


Arg Pro Pro Val Pro Gly Thr Pro Ser Thr Gln Ala Met Pro Ser Trp 
    210                 215                 220                 


Pro Thr Ala Ala Tyr Ala Thr Ser Ser Tyr Leu His Asp Ser Thr Pro 
225                 230                 235                 240 


Ser Trp Thr Leu Ser Pro Phe Gln Asp Ala Ala Ser Ser Ser Ser Ser 
                245                 250                 255     


Ser Ser Ser Ser Ala Thr Thr Thr Thr Pro Glu Thr Ser Thr Ser Pro 
            260                 265                 270         


Lys Phe His Thr Thr Thr Tyr Ser Thr Glu Arg Ser Glu His Phe Lys 
        275                 280                 285             


Pro Cys Arg Asp Lys Asp Leu Ala Tyr Cys Leu Asn Asp Gly Glu Cys 
    290                 295                 300                 


Phe Val Ile Glu Thr Leu Thr Gly Ser His Lys His Cys Arg Cys Lys 
305                 310                 315                 320 


Glu Gly Tyr Gln Gly Val Arg Cys Asp Gln Phe Leu Pro Lys Thr Asp 
                325                 330                 335     


Ser Ile Leu Ser Asp Pro Asn His Leu Gly Ile Glu Phe Met Glu Ser 
            340                 345                 350         


Glu Glu Val Tyr Gln Arg Gln Val Leu Ser Ile Ser Cys Ile Ile Phe 
        355                 360                 365             


Gly Ile Val Ile Val Gly Met Phe Cys Ala Ala Phe Tyr Phe Lys Ser 
    370                 375                 380                 


Lys Lys Gln Ala Lys Gln Ile Gln Glu Gln Leu Lys Val Pro Gln Asn 
385                 390                 395                 400 


Gly Lys Ser Tyr Ser Leu Lys Ala Ser Ser Thr Met Ala Lys Ser Glu 
                405                 410                 415     


Asn Leu Val Lys Ser His Val Gln Leu Gln Asn Tyr Ser Lys Val Glu 
            420                 425                 430         


Arg His Pro Val Thr Ala Leu Glu Lys Met Met Glu Ser Ser Phe Val 
        435                 440                 445             


Gly Pro Gln Ser Phe Pro Glu Val Pro Ser Pro Asp Arg Gly Ser Gln 
    450                 455                 460                 


Ser Val Lys His His Arg Ser Leu Ser Ser Cys Cys Ser Pro Gly Gln 
465                 470                 475                 480 


Arg Ser Gly Met Leu His Arg Asn Ala Phe Arg Arg Thr Pro Pro Ser 
                485                 490                 495     


Pro Arg Ser Arg Leu Gly Gly Ile Val Gly Pro Ala Tyr Gln Gln Leu 
            500                 505                 510         


Glu Glu Ser Arg Ile Pro Asp Gln Asp Thr Ile Pro Cys Gln Gly Tyr 
        515                 520                 525             


Ser Ser Ser Gly Leu Lys Thr Gln Arg Asn Thr Ser Ile Asn Met Gln 
    530                 535                 540                 


Leu Pro Ser Arg Glu Thr Asn Pro Tyr Phe Asn Ser Leu Glu Gln Lys 
545                 550                 555                 560 


Asp Leu Val Gly Tyr Ser Ser Thr Arg Ala Ser Ser Val Pro Ile Ile 
                565                 570                 575     


Pro Ser Val Gly Leu Glu Glu Thr Cys Leu Gln Met Pro Gly Ile Ser 
            580                 585                 590         


Glu Val Lys Ser Ile Lys Trp Cys Lys Asn Ser Tyr Ser Ala Asp Val 
        595                 600                 605             


Val Asn Val Ser Ile Pro Val Ser Asp Cys Leu Ile Ala Glu Gln Gln 
    610                 615                 620                 


Glu Val Lys Ile Leu Leu Glu Thr Val Gln Glu Gln Ile Arg Ile Leu 
625                 630                 635                 640 


Thr Asp Ala Arg Arg Ser Glu Asp Tyr Glu Leu Ala Ser Val Glu Thr 
                645                 650                 655     


Glu Asp Ser Ala Ser Glu Asn Thr Ala Phe Leu Pro Leu Ser Pro Thr 
            660                 665                 670         


Ala Lys Ser Glu Arg Glu Ala Gln Phe Val Leu Arg Asn Glu Ile Gln 
        675                 680                 685             


Arg Asp Ser Ala Leu Thr Lys 
    690                 695 


<210>  2136
<211>  499
<212>  PRT
<213>  Homo sapiens

<400>  2136

Met Glu Cys Gly Ile Pro Pro Thr Leu Val Cys Val Gly Arg Gly Gly 
1               5                   10                  15      


Gly Leu His Thr Ile Asn Ile Ile Ile Trp Tyr Tyr Phe Pro Ser Ala 
            20                  25                  30          


Trp Arg Thr Cys Phe Asn Ile Ser Ser Ser Val Gly Leu Leu Leu Thr 
        35                  40                  45              


Asn Ser Tyr Lys Phe Tyr Thr Thr Thr Tyr Ser Thr Glu Arg Ser Glu 
    50                  55                  60                  


His Phe Lys Pro Cys Arg Asp Lys Asp Leu Ala Tyr Cys Leu Asn Asp 
65                  70                  75                  80  


Gly Glu Cys Phe Val Ile Glu Thr Leu Thr Gly Ser His Lys His Cys 
                85                  90                  95      


Arg Cys Lys Glu Gly Tyr Gln Gly Val Arg Cys Asp Gln Phe Leu Pro 
            100                 105                 110         


Lys Thr Asp Ser Ile Leu Ser Asp Pro Thr Asp His Leu Gly Ile Glu 
        115                 120                 125             


Phe Met Glu Ser Glu Glu Val Tyr Gln Arg Gln Val Leu Ser Ile Ser 
    130                 135                 140                 


Cys Ile Ile Phe Gly Ile Val Ile Val Gly Met Phe Cys Ala Ala Phe 
145                 150                 155                 160 


Tyr Phe Lys Ser Lys Lys Gln Ala Lys Gln Ile Gln Glu Gln Leu Lys 
                165                 170                 175     


Val Pro Gln Asn Gly Lys Ser Tyr Ser Leu Lys Ala Ser Ser Thr Met 
            180                 185                 190         


Ala Lys Ser Glu Asn Leu Val Lys Ser His Val Gln Leu Gln Asn Tyr 
        195                 200                 205             


Ser Lys Val Glu Arg His Pro Val Thr Ala Leu Glu Lys Met Met Glu 
    210                 215                 220                 


Ser Ser Phe Val Gly Pro Gln Ser Phe Pro Glu Val Pro Ser Pro Asp 
225                 230                 235                 240 


Arg Gly Ser Gln Ser Val Lys His His Arg Ser Leu Ser Ser Cys Cys 
                245                 250                 255     


Ser Pro Gly Gln Arg Ser Gly Met Leu His Arg Asn Ala Phe Arg Arg 
            260                 265                 270         


Thr Pro Pro Ser Pro Arg Ser Arg Leu Gly Gly Ile Val Gly Pro Ala 
        275                 280                 285             


Tyr Gln Gln Leu Glu Glu Ser Arg Ile Pro Asp Gln Asp Thr Ile Pro 
    290                 295                 300                 


Cys Gln Gly Ile Glu Val Arg Lys Thr Ile Ser His Leu Pro Ile Gln 
305                 310                 315                 320 


Leu Trp Cys Val Glu Arg Pro Leu Asp Leu Lys Tyr Ser Ser Ser Gly 
                325                 330                 335     


Leu Lys Thr Gln Arg Asn Thr Ser Ile Asn Met Gln Leu Pro Ser Arg 
            340                 345                 350         


Glu Thr Asn Pro Tyr Phe Asn Ser Leu Glu Gln Lys Asp Leu Val Gly 
        355                 360                 365             


Tyr Ser Ser Thr Arg Ala Ser Ser Val Pro Ile Ile Pro Ser Val Gly 
    370                 375                 380                 


Leu Glu Glu Thr Cys Leu Gln Met Pro Gly Ile Ser Glu Val Lys Ser 
385                 390                 395                 400 


Ile Lys Trp Cys Lys Asn Ser Tyr Ser Ala Asp Val Val Asn Val Ser 
                405                 410                 415     


Ile Pro Val Ser Asp Cys Leu Ile Ala Glu Gln Gln Glu Val Lys Ile 
            420                 425                 430         


Leu Leu Glu Thr Val Gln Glu Gln Ile Arg Ile Leu Thr Asp Ala Arg 
        435                 440                 445             


Arg Ser Glu Asp Tyr Glu Leu Ala Ser Val Glu Thr Glu Asp Ser Ala 
    450                 455                 460                 


Ser Glu Asn Thr Ala Phe Leu Pro Leu Ser Pro Thr Ala Lys Ser Glu 
465                 470                 475                 480 


Arg Glu Ala Gln Phe Val Leu Arg Asn Glu Ile Gln Arg Asp Ser Ala 
                485                 490                 495     


Leu Thr Lys 
            


<210>  2137
<211>  834
<212>  PRT
<213>  Homo sapiens

<400>  2137

Met Lys His Thr Leu Ala Leu Leu Ala Pro Leu Leu Gly Leu Gly Leu 
1               5                   10                  15      


Gly Leu Ala Leu Ser Gln Leu Ala Ala Gly Ala Thr Asp Cys Lys Phe 
            20                  25                  30          


Leu Gly Pro Ala Glu His Leu Thr Phe Thr Pro Ala Ala Arg Ala Arg 
        35                  40                  45              


Trp Leu Ala Pro Arg Val Arg Ala Pro Gly Leu Leu Asp Ser Leu Tyr 
    50                  55                  60                  


Gly Thr Val Arg Arg Phe Leu Ser Val Val Gln Leu Asn Pro Phe Pro 
65                  70                  75                  80  


Ser Glu Leu Val Lys Ala Leu Leu Asn Glu Leu Ala Ser Val Lys Val 
                85                  90                  95      


Asn Glu Val Val Arg Tyr Glu Ala Gly Tyr Val Val Cys Ala Val Ile 
            100                 105                 110         


Ala Gly Leu Tyr Leu Leu Leu Val Pro Thr Ala Gly Leu Cys Phe Cys 
        115                 120                 125             


Cys Cys Arg Cys His Arg Arg Cys Gly Gly Arg Val Lys Thr Glu His 
    130                 135                 140                 


Lys Ala Leu Ala Cys Glu Arg Ala Ala Leu Met Val Phe Leu Leu Leu 
145                 150                 155                 160 


Thr Thr Leu Leu Leu Leu Ile Gly Val Val Cys Ala Phe Val Thr Asn 
                165                 170                 175     


Gln Arg Thr His Glu Gln Met Gly Pro Ser Ile Glu Ala Met Pro Glu 
            180                 185                 190         


Thr Leu Leu Ser Leu Trp Gly Leu Val Ser Asp Val Pro Gln Glu Leu 
        195                 200                 205             


Gln Ala Val Ala Gln Gln Phe Ser Leu Pro Gln Glu Gln Val Ser Glu 
    210                 215                 220                 


Glu Leu Asp Gly Val Gly Val Ser Ile Gly Ser Ala Ile His Thr Gln 
225                 230                 235                 240 


Leu Arg Ser Ser Val Tyr Pro Leu Leu Ala Ala Val Gly Ser Leu Gly 
                245                 250                 255     


Gln Val Leu Gln Val Ser Val His His Leu Gln Thr Leu Asn Ala Thr 
            260                 265                 270         


Val Val Glu Leu Gln Ala Gly Gln Gln Asp Leu Glu Pro Ala Ile Arg 
        275                 280                 285             


Glu His Arg Asp Arg Leu Leu Glu Leu Leu Gln Glu Ala Arg Cys Gln 
    290                 295                 300                 


Gly Asp Cys Ala Gly Ala Leu Ser Trp Ala Arg Thr Leu Glu Leu Gly 
305                 310                 315                 320 


Ala Asp Phe Ser Gln Val Pro Ser Val Asp His Val Leu His Gln Leu 
                325                 330                 335     


Lys Gly Val Pro Glu Ala Asn Phe Ser Ser Met Val Gln Glu Glu Asn 
            340                 345                 350         


Ser Thr Phe Asn Ala Leu Pro Ala Leu Ala Ala Met Gln Thr Ser Ser 
        355                 360                 365             


Val Val Gln Glu Leu Lys Lys Ala Val Ala Gln Gln Pro Glu Gly Val 
    370                 375                 380                 


Arg Thr Leu Ala Glu Gly Phe Pro Gly Leu Glu Ala Ala Ser Arg Trp 
385                 390                 395                 400 


Ala Gln Ala Leu Gln Glu Val Glu Glu Ser Ser Arg Pro Tyr Leu Gln 
                405                 410                 415     


Glu Val Gln Arg Tyr Glu Thr Tyr Arg Trp Ile Val Gly Cys Val Leu 
            420                 425                 430         


Cys Ser Val Val Leu Phe Val Val Leu Cys Asn Leu Leu Gly Leu Asn 
        435                 440                 445             


Leu Gly Ile Trp Gly Leu Ser Ala Arg Asp Asp Pro Ser His Pro Glu 
    450                 455                 460                 


Ala Lys Gly Glu Ala Gly Ala Arg Phe Leu Met Ala Gly Val Gly Leu 
465                 470                 475                 480 


Ser Phe Leu Phe Ala Ala Pro Leu Ile Leu Leu Val Phe Ala Thr Phe 
                485                 490                 495     


Leu Val Gly Gly Asn Val Gln Thr Leu Val Cys Gln Ser Trp Glu Asn 
            500                 505                 510         


Gly Glu Leu Phe Glu Phe Ala Asp Thr Pro Gly Asn Leu Pro Pro Ser 
        515                 520                 525             


Met Asn Leu Ser Gln Leu Leu Gly Leu Arg Lys Asn Ile Ser Ile His 
    530                 535                 540                 


Gln Ala Tyr Gln Gln Cys Lys Glu Gly Ala Ala Leu Trp Thr Val Leu 
545                 550                 555                 560 


Gln Leu Asn Asp Ser Tyr Asp Leu Glu Glu His Leu Asp Ile Asn Gln 
                565                 570                 575     


Tyr Thr Asn Lys Leu Arg Gln Glu Leu Gln Ser Leu Lys Val Asp Thr 
            580                 585                 590         


Gln Ser Leu Asp Leu Leu Ser Ser Ala Ala Arg Arg Asp Leu Glu Ala 
        595                 600                 605             


Leu Gln Ser Ser Gly Leu Gln Arg Ile His Tyr Pro Asp Phe Leu Val 
    610                 615                 620                 


Gln Ile Gln Arg Pro Val Val Lys Thr Ser Met Glu Gln Leu Ala Gln 
625                 630                 635                 640 


Glu Leu Gln Gly Leu Ala Gln Ala Gln Asp Asn Ser Val Leu Gly Gln 
                645                 650                 655     


Arg Leu Gln Glu Glu Ala Gln Gly Leu Arg Asn Leu His Gln Glu Lys 
            660                 665                 670         


Val Val Pro Gln Gln Ser Leu Val Ala Lys Leu Asn Leu Ser Val Arg 
        675                 680                 685             


Ala Leu Glu Ser Ser Ala Pro Asn Leu Gln Leu Glu Thr Ser Asp Val 
    690                 695                 700                 


Leu Ala Asn Val Thr Tyr Leu Lys Gly Glu Leu Pro Ala Trp Ala Ala 
705                 710                 715                 720 


Arg Ile Leu Arg Asn Val Ser Glu Cys Phe Leu Ala Arg Glu Met Gly 
                725                 730                 735     


Tyr Phe Ser Gln Tyr Val Ala Trp Val Arg Glu Glu Val Thr Gln Arg 
            740                 745                 750         


Ile Ala Thr Cys Gln Pro Leu Ser Gly Ala Leu Asp Asn Ser Arg Val 
        755                 760                 765             


Ile Leu Cys Asp Met Met Ala Asp Pro Trp Asn Ala Phe Trp Phe Cys 
    770                 775                 780                 


Leu Ala Trp Cys Thr Phe Phe Leu Ile Pro Ser Ile Ile Phe Ala Val 
785                 790                 795                 800 


Lys Thr Ser Lys Tyr Phe Arg Pro Ile Arg Lys Arg Leu Ser Ser Thr 
                805                 810                 815     


Ser Ser Glu Glu Thr Gln Leu Phe His Ile Pro Arg Val Thr Ser Leu 
            820                 825                 830         


Lys Leu 
        


<210>  2138
<211>  834
<212>  PRT
<213>  Homo sapiens

<400>  2138

Met Lys His Thr Leu Ala Leu Leu Ala Pro Leu Leu Gly Leu Gly Leu 
1               5                   10                  15      


Gly Leu Ala Leu Ser Gln Leu Ala Ala Gly Ala Thr Asp Cys Lys Phe 
            20                  25                  30          


Leu Gly Pro Ala Glu His Leu Thr Phe Thr Pro Ala Ala Arg Ala Arg 
        35                  40                  45              


Trp Leu Ala Pro Arg Val Arg Ala Pro Gly Leu Leu Asp Ser Leu Tyr 
    50                  55                  60                  


Gly Thr Val Arg Arg Phe Leu Ser Val Val Gln Leu Asn Pro Phe Pro 
65                  70                  75                  80  


Ser Glu Leu Val Lys Ala Leu Leu Asn Glu Leu Ala Ser Val Lys Val 
                85                  90                  95      


Asn Glu Val Val Arg Tyr Glu Ala Gly Tyr Val Val Cys Ala Val Ile 
            100                 105                 110         


Ala Gly Leu Tyr Leu Leu Leu Val Pro Thr Ala Gly Leu Cys Phe Cys 
        115                 120                 125             


Cys Cys Arg Cys His Arg Arg Cys Gly Gly Arg Val Lys Thr Glu His 
    130                 135                 140                 


Lys Ala Leu Ala Cys Glu Arg Ala Ala Leu Met Val Phe Leu Leu Leu 
145                 150                 155                 160 


Thr Thr Leu Leu Leu Leu Ile Gly Val Val Cys Ala Phe Val Thr Asn 
                165                 170                 175     


Gln Arg Thr His Glu Gln Met Gly Pro Ser Ile Glu Ala Met Pro Glu 
            180                 185                 190         


Thr Leu Leu Ser Leu Trp Gly Leu Val Ser Asp Val Pro Gln Glu Leu 
        195                 200                 205             


Gln Ala Val Ala Gln Gln Phe Ser Leu Pro Gln Glu Gln Val Ser Glu 
    210                 215                 220                 


Glu Leu Asp Gly Val Gly Val Ser Ile Gly Ser Ala Ile His Thr Gln 
225                 230                 235                 240 


Leu Arg Ser Ser Val Tyr Pro Leu Leu Ala Ala Val Gly Ser Leu Gly 
                245                 250                 255     


Gln Val Leu Gln Val Ser Val His His Leu Gln Thr Leu Asn Ala Thr 
            260                 265                 270         


Val Val Glu Leu Gln Ala Gly Gln Gln Asp Leu Glu Pro Ala Ile Arg 
        275                 280                 285             


Glu His Arg Asp Arg Leu Leu Glu Leu Leu Gln Glu Ala Arg Cys Gln 
    290                 295                 300                 


Gly Asp Cys Ala Gly Ala Leu Ser Trp Ala Arg Thr Leu Glu Leu Gly 
305                 310                 315                 320 


Ala Asp Phe Ser Gln Val Pro Ser Val Asp His Val Leu His Gln Leu 
                325                 330                 335     


Lys Gly Val Pro Glu Ala Asn Phe Ser Ser Met Val Gln Glu Glu Asn 
            340                 345                 350         


Ser Thr Phe Asn Ala Leu Pro Ala Leu Ala Ala Met Gln Thr Ser Ser 
        355                 360                 365             


Val Val Gln Glu Leu Lys Lys Ala Val Ala Gln Gln Pro Glu Gly Val 
    370                 375                 380                 


Arg Thr Leu Ala Glu Gly Phe Pro Gly Leu Glu Ala Ala Ser Arg Trp 
385                 390                 395                 400 


Ala Gln Ala Leu Gln Glu Val Glu Glu Ser Ser Arg Pro Tyr Leu Gln 
                405                 410                 415     


Glu Val Gln Arg Tyr Glu Thr Tyr Arg Trp Ile Val Gly Cys Val Leu 
            420                 425                 430         


Cys Ser Val Val Leu Phe Val Val Leu Cys Asn Leu Leu Gly Leu Asn 
        435                 440                 445             


Leu Gly Ile Trp Gly Leu Ser Ala Arg Asp Asp Pro Ser His Pro Glu 
    450                 455                 460                 


Ala Lys Gly Glu Ala Gly Ala Arg Phe Leu Met Ala Gly Val Gly Leu 
465                 470                 475                 480 


Ser Phe Leu Phe Ala Ala Pro Leu Ile Leu Leu Val Phe Ala Thr Phe 
                485                 490                 495     


Leu Val Gly Gly Asn Val Gln Thr Leu Val Cys Gln Ser Trp Glu Asn 
            500                 505                 510         


Gly Glu Leu Phe Glu Phe Ala Asp Thr Pro Gly Asn Leu Pro Pro Ser 
        515                 520                 525             


Met Asn Leu Ser Gln Leu Leu Gly Leu Arg Lys Asn Ile Ser Ile His 
    530                 535                 540                 


Gln Ala Tyr Gln Gln Cys Lys Glu Gly Ala Ala Leu Trp Thr Val Leu 
545                 550                 555                 560 


Gln Leu Asn Asp Ser Tyr Asp Leu Glu Glu His Leu Asp Ile Asn Gln 
                565                 570                 575     


Tyr Thr Asn Lys Leu Arg Gln Glu Leu Gln Ser Leu Lys Val Asp Thr 
            580                 585                 590         


Gln Ser Leu Asp Leu Leu Ser Ser Ala Ala Arg Arg Asp Leu Glu Ala 
        595                 600                 605             


Leu Gln Ser Ser Gly Leu Gln Arg Ile His Tyr Pro Asp Phe Leu Val 
    610                 615                 620                 


Gln Ile Gln Arg Pro Val Val Lys Thr Ser Met Glu Gln Leu Ala Gln 
625                 630                 635                 640 


Glu Leu Gln Gly Leu Ala Gln Ala Gln Asp Asn Ser Val Leu Gly Gln 
                645                 650                 655     


Arg Leu Gln Glu Glu Ala Gln Gly Leu Arg Asn Leu His Gln Glu Lys 
            660                 665                 670         


Val Val Pro Gln Gln Ser Leu Val Ala Lys Leu Asn Leu Ser Val Arg 
        675                 680                 685             


Ala Leu Glu Ser Ser Ala Pro Asn Leu Gln Leu Glu Thr Ser Asp Val 
    690                 695                 700                 


Leu Ala Asn Val Thr Tyr Leu Lys Gly Glu Leu Pro Ala Trp Ala Ala 
705                 710                 715                 720 


Arg Ile Leu Arg Asn Val Ser Glu Cys Phe Leu Ala Arg Glu Met Gly 
                725                 730                 735     


Tyr Phe Ser Gln Tyr Val Ala Trp Val Arg Glu Glu Val Thr Gln Arg 
            740                 745                 750         


Ile Ala Thr Cys Gln Pro Leu Ser Gly Ala Leu Asp Asn Ser Arg Val 
        755                 760                 765             


Ile Leu Cys Asp Met Met Ala Asp Pro Trp Asn Ala Phe Trp Phe Cys 
    770                 775                 780                 


Leu Ala Trp Cys Thr Phe Phe Leu Ile Pro Ser Ile Ile Phe Ala Val 
785                 790                 795                 800 


Lys Thr Ser Lys Tyr Phe Arg Pro Ile Arg Lys Arg Leu Ser Ser Thr 
                805                 810                 815     


Ser Ser Glu Glu Thr Gln Leu Phe His Ile Pro Arg Val Thr Ser Leu 
            820                 825                 830         


Lys Leu 
        


<210>  2139
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  2139

Met Ser Ser Thr Ala Ala Phe Tyr Leu Leu Ser Thr Leu Gly Gly Tyr 
1               5                   10                  15      


Leu Val Thr Ser Phe Leu Leu Leu Lys Tyr Pro Thr Leu Leu His Gln 
            20                  25                  30          


Arg Lys Lys Gln Arg Phe Leu Ser Lys His Ile Ser His Arg Gly Gly 
        35                  40                  45              


Ala Gly Glu Asn Leu Glu Asn Thr Met Ala Ala Phe Gln His Ala Val 
    50                  55                  60                  


Lys Ile Gly Thr Asp Met Leu Glu Leu Asp Cys His Ile Thr Lys Asp 
65                  70                  75                  80  


Glu Gln Val Val Val Ser His Asp Glu Asn Leu Lys Arg Ala Thr Gly 
                85                  90                  95      


Val Asn Val Asn Ile Ser Asp Leu Lys Tyr Cys Glu Leu Pro Pro Tyr 
            100                 105                 110         


Leu Gly Lys Leu Asp Val Ser Phe Gln Arg Ala Cys Gln Cys Glu Gly 
        115                 120                 125             


Lys Asp Asn Arg Ile Pro Leu Leu Lys Glu Val Phe Glu Ala Phe Pro 
    130                 135                 140                 


Asn Thr Pro Ile Asn Ile Asp Ile Lys Val Asn Asn Asn Val Leu Ile 
145                 150                 155                 160 


Lys Lys Val Ser Glu Leu Val Lys Arg Tyr Asn Arg Glu His Leu Thr 
                165                 170                 175     


Val Trp Gly Asn Ala Asn Tyr Glu Ile Val Glu Lys Cys Tyr Lys Glu 
            180                 185                 190         


Asn Ser Asp Ile Pro Ile Leu Phe Ser Leu Gln Arg Val Leu Leu Ile 
        195                 200                 205             


Leu Gly Leu Phe Phe Thr Gly Leu Leu Pro Phe Val Pro Ile Arg Glu 
    210                 215                 220                 


Gln Phe Phe Glu Ile Pro Met Pro Ser Ile Ile Leu Lys Leu Lys Glu 
225                 230                 235                 240 


Pro His Thr Met Ser Arg Ser Gln Lys Phe Leu Ile Trp Leu Ser Asp 
                245                 250                 255     


Leu Leu Leu Met Arg Lys Ala Leu Phe Glu Pro Leu His Pro Ala Ser 
            260                 265                 270         


Lys Arg Asn Phe Glu Gly His Cys Ser Tyr Leu Val Val Ser Cys Tyr 
        275                 280                 285             


Phe 
    


<210>  2140
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  2140

Met Ser Ser Thr Ala Ala Phe Tyr Leu Leu Ser Thr Leu Gly Gly Tyr 
1               5                   10                  15      


Leu Val Thr Ser Phe Leu Leu Leu Lys Tyr Pro Thr Leu Leu His Gln 
            20                  25                  30          


Arg Lys Lys Gln Arg Phe Leu Ser Lys His Ile Ser His Arg Gly Gly 
        35                  40                  45              


Ala Gly Glu Asn Leu Glu Asn Thr Met Ala Ala Phe Gln His Ala Val 
    50                  55                  60                  


Lys Ile Gly Thr Asp Met Leu Glu Leu Asp Cys His Ile Thr Lys Asp 
65                  70                  75                  80  


Glu Gln Val Val Val Ser His Asp Glu Asn Leu Lys Arg Ala Thr Gly 
                85                  90                  95      


Val Asn Val Asn Ile Ser Asp Leu Lys Tyr Cys Glu Leu Pro Pro Tyr 
            100                 105                 110         


Leu Gly Lys Leu Asp Val Ser Phe Gln Arg Ala Cys Gln Cys Glu Gly 
        115                 120                 125             


Lys Asp Asn Arg Ile Pro Leu Leu Lys Glu Val Phe Glu Ala Phe Pro 
    130                 135                 140                 


Asn Thr Pro Ile Asn Ile Asp Ile Lys Val Asn Asn Asn Val Leu Ile 
145                 150                 155                 160 


Lys Lys Val Ser Glu Leu Val Lys Arg Tyr Asn Arg Glu His Leu Thr 
                165                 170                 175     


Val Trp Gly Asn Ala Asn Tyr Glu Ile Val Glu Lys Cys Tyr Lys Glu 
            180                 185                 190         


Asn Ser Asp Ile Pro Ile Leu Phe Ser Leu Gln Arg Val Leu Leu Ile 
        195                 200                 205             


Leu Gly Leu Phe Phe Thr Gly Leu Leu Pro Phe Val Pro Ile Arg Glu 
    210                 215                 220                 


Gln Phe Phe Glu Ile Pro Met Pro Ser Ile Ile Leu Lys Leu Lys Glu 
225                 230                 235                 240 


Pro His Thr Met Ser Arg Ser Gln Lys Phe Leu Ile Trp Leu Ser Asp 
                245                 250                 255     


Leu Leu Leu Met Arg Lys Ala Leu Phe Asp His Leu Thr Ala Arg Gly 
            260                 265                 270         


Ile Gln Val Ser Phe Trp Asn Asp Ala Phe Trp Lys Gln His Ser Ser 
        275                 280                 285             


Pro Val 
    290 


<210>  2141
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  2141

Met Glu Thr Leu Cys Leu Arg Ala Ser Phe Trp Leu Ala Leu Val Gly 
1               5                   10                  15      


Cys Val Ile Ser Asp Asn Pro Glu Arg Tyr Ser Thr Asn Leu Ser Asn 
            20                  25                  30          


His Val Asp Asp Phe Thr Thr Phe Arg Gly Thr Glu Leu Ser Phe Leu 
        35                  40                  45              


Val Thr Thr His Gln Pro Thr Asn Leu Val Leu Pro Ser Asn Gly Ser 
    50                  55                  60                  


Met His Asn Tyr Cys Pro Gln Gln Thr Lys Ile Thr Ser Ala Phe Lys 
65                  70                  75                  80  


Tyr Ile Asn Thr Val Ile Ser Cys Thr Ile Phe Ile Val Gly Met Val 
                85                  90                  95      


Gly Asn Ala Thr Leu Leu Arg Ile Ile Tyr Gln Asn Lys Cys Met Arg 
            100                 105                 110         


Asn Gly Pro Asn Ala Leu Ile Ala Ser Leu Ala Leu Gly Asp Leu Ile 
        115                 120                 125             


Tyr Val Val Ile Asp Leu Pro Ile Asn Val Phe Lys Phe Tyr Gln Asp 
    130                 135                 140                 


Val Lys Asp Trp Trp Leu Phe Gly Phe Tyr Phe Cys Met Pro Leu Val 
145                 150                 155                 160 


Cys Thr Ala Ile Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Asn Arg 
                165                 170                 175     


Arg Asn Gly Ser Leu Arg Ile Ala Leu Ser Glu His Leu Lys Gln Arg 
            180                 185                 190         


Arg Glu Val Ala Lys Thr Val Phe Cys Leu Val Val Ile Phe Ala Leu 
        195                 200                 205             


Cys Trp Phe Pro Leu His Leu Ser Arg Ile Leu Lys Lys Thr Val Tyr 
    210                 215                 220                 


Asn Glu Met Asp Lys Asn Arg Cys Glu Leu Leu Ser Phe Leu Leu Leu 
225                 230                 235                 240 


Met Asp Tyr Ile Gly Ile Asn Leu Ala Thr Met Asn Ser Cys Ile Asn 
                245                 250                 255     


Pro Ile Ala Leu Tyr Phe Val Ser Lys Lys Phe Lys Asn Cys Phe Gln 
            260                 265                 270         


Ser Cys Leu Cys Cys Cys Cys Tyr Gln Ser Lys Ser Leu Met Thr Ser 
        275                 280                 285             


Val Pro Met Asn Gly Thr Ser Ile Gln Trp Lys Asn His Asp Gln Asn 
    290                 295                 300                 


Asn His Asn Thr Asp Arg Ser Ser His Lys Asp Ser Met Asn 
305                 310                 315             


<210>  2142
<211>  730
<212>  PRT
<213>  Homo sapiens

<400>  2142

Met Ile Val Phe Leu Val Phe Lys His Leu Phe Ser Leu Arg Leu Ile 
1               5                   10                  15      


Thr Met Phe Phe Leu Leu His Phe Ile Val Leu Ile Asn Val Lys Asp 
            20                  25                  30          


Phe Ala Leu Thr Gln Gly Ser Met Ile Thr Pro Ser Cys Gln Lys Gly 
        35                  40                  45              


Tyr Phe Pro Cys Gly Asn Leu Thr Lys Cys Leu Pro Arg Ala Phe His 
    50                  55                  60                  


Cys Asp Gly Lys Asp Asp Cys Gly Asn Gly Ala Asp Glu Glu Asn Cys 
65                  70                  75                  80  


Gly Asp Thr Ser Gly Trp Ala Thr Ile Phe Gly Thr Val His Gly Asn 
                85                  90                  95      


Ala Asn Ser Val Ala Leu Thr Gln Glu Cys Phe Leu Lys Gln Tyr Pro 
            100                 105                 110         


Gln Cys Cys Asp Cys Lys Glu Thr Glu Leu Glu Cys Val Asn Gly Asp 
        115                 120                 125             


Leu Lys Ser Val Pro Met Ile Ser Asn Asn Val Thr Leu Leu Ser Leu 
    130                 135                 140                 


Lys Lys Asn Lys Ile His Ser Leu Pro Asp Lys Val Phe Ile Lys Tyr 
145                 150                 155                 160 


Thr Lys Leu Lys Lys Ile Phe Leu Gln His Asn Cys Ile Arg His Ile 
                165                 170                 175     


Ser Arg Lys Ala Phe Phe Gly Leu Cys Asn Leu Gln Ile Leu Tyr Leu 
            180                 185                 190         


Asn His Asn Cys Ile Thr Thr Leu Arg Pro Gly Ile Phe Lys Asp Leu 
        195                 200                 205             


His Gln Leu Thr Trp Leu Ile Leu Asp Asp Asn Pro Ile Thr Arg Ile 
    210                 215                 220                 


Ser Gln Arg Leu Phe Thr Gly Leu Asn Ser Leu Phe Phe Leu Ser Met 
225                 230                 235                 240 


Val Asn Asn Tyr Leu Glu Ala Leu Pro Lys Gln Met Cys Ala Gln Met 
                245                 250                 255     


Pro Gln Leu Asn Trp Val Asp Leu Glu Gly Asn Arg Ile Lys Tyr Leu 
            260                 265                 270         


Thr Asn Ser Thr Phe Leu Ser Cys Asp Ser Leu Thr Val Leu Asp Leu 
        275                 280                 285             


Ser Ser Asn Thr Ile Thr Glu Leu Ser Pro His Leu Phe Lys Asp Leu 
    290                 295                 300                 


Lys Leu Leu Gln Lys Leu Asn Leu Ser Ser Asn Pro Leu Met Tyr Leu 
305                 310                 315                 320 


His Lys Asn Gln Phe Glu Ser Leu Lys Gln Leu Gln Ser Leu Asp Leu 
                325                 330                 335     


Glu Arg Ile Glu Ile Pro Asn Ile Asn Thr Arg Met Phe Gln Pro Met 
            340                 345                 350         


Lys Asn Leu Ser His Ile Tyr Phe Lys Asn Phe Arg Tyr Cys Ser Tyr 
        355                 360                 365             


Ala Pro His Val Arg Ile Cys Met Pro Leu Thr Asp Gly Ile Ser Ser 
    370                 375                 380                 


Phe Glu Asp Leu Leu Ala Asn Asn Ile Leu Arg Ile Phe Val Trp Val 
385                 390                 395                 400 


Ile Ala Phe Ile Thr Cys Phe Gly Asn Leu Phe Val Ile Gly Met Arg 
                405                 410                 415     


Ser Phe Ile Lys Ala Glu Asn Thr Thr His Ala Met Ser Ile Lys Ile 
            420                 425                 430         


Leu Cys Cys Ala Asp Cys Leu Met Gly Val Tyr Leu Phe Phe Val Gly 
        435                 440                 445             


Ile Phe Asp Ile Lys Tyr Arg Gly Gln Tyr Gln Lys Tyr Ala Leu Leu 
    450                 455                 460                 


Trp Met Glu Ser Val Gln Cys Arg Leu Met Gly Phe Leu Ala Met Leu 
465                 470                 475                 480 


Ser Thr Glu Val Ser Val Leu Leu Leu Thr Tyr Leu Thr Leu Glu Lys 
                485                 490                 495     


Phe Leu Val Ile Val Phe Pro Phe Ser Asn Ile Arg Pro Gly Lys Arg 
            500                 505                 510         


Gln Thr Ser Val Ile Leu Ile Cys Ile Trp Met Ala Gly Phe Leu Ile 
        515                 520                 525             


Ala Val Ile Pro Phe Trp Asn Lys Asp Tyr Phe Gly Asn Phe Tyr Gly 
    530                 535                 540                 


Lys Asn Gly Val Cys Phe Pro Leu Tyr Tyr Asp Gln Thr Glu Asp Ile 
545                 550                 555                 560 


Gly Ser Lys Gly Tyr Ser Leu Gly Ile Phe Leu Gly Val Asn Leu Leu 
                565                 570                 575     


Ala Phe Leu Ile Ile Val Phe Ser Tyr Ile Thr Met Phe Cys Ser Ile 
            580                 585                 590         


Gln Lys Thr Ala Leu Gln Thr Thr Glu Val Arg Asn Cys Phe Gly Arg 
        595                 600                 605             


Glu Val Ala Val Ala Asn Arg Phe Phe Phe Ile Val Phe Ser Asp Ala 
    610                 615                 620                 


Ile Cys Trp Ile Pro Val Phe Val Val Lys Ile Leu Ser Leu Phe Arg 
625                 630                 635                 640 


Val Glu Ile Pro Asp Thr Met Thr Ser Trp Ile Val Ile Phe Phe Leu 
                645                 650                 655     


Pro Val Asn Ser Ala Leu Asn Pro Ile Leu Tyr Thr Leu Thr Thr Asn 
            660                 665                 670         


Phe Phe Lys Asp Lys Leu Lys Gln Leu Leu His Lys His Gln Arg Lys 
        675                 680                 685             


Ser Ile Phe Lys Ile Lys Lys Lys Ser Leu Ser Thr Ser Ile Val Trp 
    690                 695                 700                 


Ile Glu Asp Ser Ser Ser Leu Lys Leu Gly Val Leu Asn Lys Ile Thr 
705                 710                 715                 720 


Leu Gly Asp Ser Ile Met Lys Pro Val Ser 
                725                 730 


<210>  2143
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  2143

Met Lys Phe Leu Leu Thr Thr Ala Phe Leu Ile Leu Ile Ser Leu Trp 
1               5                   10                  15      


Val Glu Glu Ala Tyr Ser Lys Glu Lys Ser Ser Lys Lys Gly Lys Gly 
            20                  25                  30          


Lys Lys Lys Gln Tyr Leu Cys Pro Ser Gln Gln Ser Ala Glu Asp Leu 
        35                  40                  45              


Ala Arg Val Pro Ala Asn Ser Thr Ser Asn Ile Leu Asn Arg Leu Leu 
    50                  55                  60                  


Val Ser Tyr Asp Pro Arg Ile Arg Pro Asn Phe Lys Gly Ile Pro Val 
65                  70                  75                  80  


Asp Val Val Val Asn Ile Phe Ile Asn Ser Phe Gly Ser Ile Gln Glu 
                85                  90                  95      


Thr Thr Met Asp Tyr Arg Val Asn Ile Phe Leu Arg Gln Lys Trp Asn 
            100                 105                 110         


Asp Pro Arg Leu Lys Leu Pro Ser Asp Phe Arg Gly Ser Asp Ala Leu 
        115                 120                 125             


Thr Val Asp Pro Thr Met Tyr Lys Cys Leu Trp Lys Pro Asp Leu Phe 
    130                 135                 140                 


Phe Ala Asn Glu Lys Ser Ala Asn Phe His Asp Val Thr Gln Glu Asn 
145                 150                 155                 160 


Ile Leu Leu Phe Ile Phe Arg Asp Gly Asp Val Leu Val Ser Met Arg 
                165                 170                 175     


Leu Ser Ile Thr Leu Ser Cys Pro Leu Asp Leu Thr Leu Phe Pro Met 
            180                 185                 190         


Asp Thr Gln Arg Cys Lys Met Gln Leu Glu Ser Phe Gly Tyr Thr Thr 
        195                 200                 205             


Asp Asp Leu Arg Phe Ile Trp Gln Ser Gly Asp Pro Val Gln Leu Glu 
    210                 215                 220                 


Lys Ile Ala Leu Pro Gln Phe Asp Ile Lys Lys Glu Asp Ile Glu Tyr 
225                 230                 235                 240 


Gly Asn Cys Thr Lys Tyr Tyr Lys Gly Thr Gly Tyr Tyr Thr Cys Val 
                245                 250                 255     


Glu Val Ile Phe Thr Leu Arg Arg Gln Val Gly Phe Tyr Met Met Gly 
            260                 265                 270         


Val Tyr Ala Pro Thr Leu Leu Ile Val Val Leu Ser Trp Leu Ser Phe 
        275                 280                 285             


Trp Ile Asn Pro Asp Ala Ser Ala Ala Arg Val Pro Leu Gly Ile Phe 
    290                 295                 300                 


Ser Val Leu Ser Leu Ala Ser Glu Cys Thr Thr Leu Ala Ala Glu Leu 
305                 310                 315                 320 


Pro Lys Val Ser Tyr Val Lys Ala Leu Asp Val Trp Leu Ile Ala Cys 
                325                 330                 335     


Leu Leu Phe Gly Phe Ala Ser Leu Val Glu Tyr Ala Val Val Gln Val 
            340                 345                 350         


Met Leu Asn Asn Pro Lys Arg Val Glu Ala Glu Lys Ala Arg Ile Ala 
        355                 360                 365             


Lys Ala Glu Gln Ala Asp Gly Lys Gly Gly Asn Val Ala Lys Lys Asn 
    370                 375                 380                 


Thr Val Asn Gly Thr Gly Thr Pro Val His Ile Ser Thr Leu Gln Val 
385                 390                 395                 400 


Gly Glu Thr Arg Cys Lys Lys Val Cys Thr Ser Lys Ser Asp Leu Arg 
                405                 410                 415     


Ser Asn Asp Phe Ser Ile Val Gly Ser Leu Pro Arg Asp Phe Glu Leu 
            420                 425                 430         


Ser Asn Tyr Asp Cys Tyr Gly Lys Pro Ile Glu Val Asn Asn Gly Leu 
        435                 440                 445             


Gly Lys Ser Gln Ala Lys Asn Asn Lys Lys Pro Pro Pro Ala Lys Pro 
    450                 455                 460                 


Val Ile Pro Thr Ala Ala Lys Arg Ile Asp Leu Tyr Ala Arg Ala Leu 
465                 470                 475                 480 


Phe Pro Phe Cys Phe Leu Phe Phe Asn Val Ile Tyr Trp Ser Ile Tyr 
                485                 490                 495     


Leu 
    


<210>  2144
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  2144

Met Lys Phe Leu Leu Thr Thr Ala Phe Leu Ile Leu Ile Ser Leu Trp 
1               5                   10                  15      


Val Glu Glu Ala Tyr Ser Lys Glu Lys Ser Ser Lys Lys Gly Lys Gly 
            20                  25                  30          


Lys Lys Lys Gln Tyr Leu Cys Pro Ser Gln Gln Ser Ala Glu Asp Leu 
        35                  40                  45              


Ala Arg Val Pro Ala Asn Ser Thr Ser Asn Ile Leu Asn Arg Leu Leu 
    50                  55                  60                  


Val Ser Tyr Asp Pro Arg Ile Arg Pro Asn Phe Lys Gly Ile Pro Val 
65                  70                  75                  80  


Asp Val Val Val Asn Ile Phe Ile Asn Ser Phe Gly Ser Ile Gln Glu 
                85                  90                  95      


Thr Thr Met Asp Tyr Arg Val Asn Ile Phe Leu Arg Gln Lys Trp Asn 
            100                 105                 110         


Asp Pro Arg Leu Lys Leu Pro Ser Asp Phe Arg Gly Ser Asp Ala Leu 
        115                 120                 125             


Thr Val Asp Pro Thr Met Tyr Lys Cys Leu Trp Lys Pro Asp Leu Phe 
    130                 135                 140                 


Phe Ala Asn Glu Lys Ser Ala Asn Phe His Asp Val Thr Gln Glu Asn 
145                 150                 155                 160 


Ile Leu Leu Phe Ile Phe Arg Asp Gly Asp Val Leu Val Ser Met Arg 
                165                 170                 175     


Leu Ser Ile Thr Leu Ser Cys Pro Leu Asp Leu Thr Leu Phe Pro Met 
            180                 185                 190         


Asp Thr Gln Arg Cys Lys Met Gln Leu Glu Ser Phe Gly Tyr Thr Thr 
        195                 200                 205             


Asp Asp Leu Arg Phe Ile Trp Gln Ser Gly Asp Pro Val Gln Leu Glu 
    210                 215                 220                 


Lys Ile Ala Leu Pro Gln Phe Asp Ile Lys Lys Glu Asp Ile Glu Tyr 
225                 230                 235                 240 


Gly Asn Cys Thr Lys Tyr Tyr Lys Gly Thr Gly Tyr Tyr Thr Cys Val 
                245                 250                 255     


Glu Val Ile Phe Thr Leu Arg Arg Gln Val Gly Phe Tyr Met Met Gly 
            260                 265                 270         


Val Tyr Ala Pro Thr Leu Leu Ile Val Val Leu Ser Trp Leu Ser Phe 
        275                 280                 285             


Trp Ile Asn Pro Asp Ala Ser Ala Ala Arg Val Pro Leu Gly Trp 
    290                 295                 300             


<210>  2145
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  2145

Met Ala Gln Leu Cys Gly Leu Arg Arg Ser Arg Ala Phe Leu Ala Leu 
1               5                   10                  15      


Leu Gly Ser Leu Leu Leu Ser Gly Val Leu Ala Ala Asp Arg Glu Arg 
            20                  25                  30          


Ser Ile His Glu Asn Ala Thr Gly Asp Leu Ala Thr Ser Arg Asn Ala 
        35                  40                  45              


Ala Asp Ser Ser Val Pro Ser Ala Pro Arg Arg Gln Asp Ser Glu Asp 
    50                  55                  60                  


His Ser Ser Asp Met Phe Asn Tyr Glu Glu Tyr Cys Thr Ala Asn Ala 
65                  70                  75                  80  


Val Thr Gly Pro Cys Arg Ala Ser Phe Pro Arg Trp Tyr Phe Asp Val 
                85                  90                  95      


Glu Arg Asn Ser Cys Asn Asn Phe Ile Tyr Gly Gly Cys Arg Gly Asn 
            100                 105                 110         


Lys Asn Ser Tyr Arg Ser Glu Glu Ala Cys Met Leu Arg Cys Phe Arg 
        115                 120                 125             


Gln Gln Glu Asn Pro Pro Leu Pro Leu Gly Ser Lys Val Val Val Leu 
    130                 135                 140                 


Ala Gly Leu Phe Val Met Val Leu Ile Leu Phe Leu Gly Ala Ser Met 
145                 150                 155                 160 


Val Tyr Leu Ile Arg Val Ala Arg Arg Asn Gln Glu Arg Ala Leu Arg 
                165                 170                 175     


Thr Val Trp Ser Ser Gly Asp Asp Lys Glu Gln Leu Val Lys Asn Thr 
            180                 185                 190         


Tyr Val Leu 
        195 


<210>  2146
<211>  1375
<212>  PRT
<213>  Homo sapiens

<400>  2146

Met Glu Ala Pro Leu Gln Thr Gly Met Met Gly Thr Ser Ser His Gly 
1               5                   10                  15      


Leu Ala Thr Asn Ser Ser Gly Ala Lys Val Ala Glu Arg Asp Gly Phe 
            20                  25                  30          


Gln Asp Val Leu Ala Pro Gly Glu Gly Ser Ala Gly Arg Ile Cys Gly 
        35                  40                  45              


Ala Gln Pro Val Pro Phe Val Pro Gln Val Leu Gly Val Met Ile Gly 
    50                  55                  60                  


Ala Gly Val Ala Val Val Val Thr Ala Val Leu Ile Leu Leu Val Val 
65                  70                  75                  80  


Arg Arg Leu Arg Val Pro Lys Thr Pro Ala Pro Asp Gly Pro Arg Tyr 
                85                  90                  95      


Arg Phe Arg Lys Arg Asp Lys Val Leu Phe Tyr Gly Arg Lys Ile Met 
            100                 105                 110         


Arg Lys Val Ser Gln Ser Thr Ser Ser Leu Val Asp Thr Ser Val Ser 
        115                 120                 125             


Ala Thr Ser Arg Pro Arg Met Arg Lys Lys Leu Lys Met Leu Asn Ile 
    130                 135                 140                 


Ala Lys Lys Ile Leu Arg Ile Gln Lys Glu Thr Pro Thr Leu Gln Arg 
145                 150                 155                 160 


Lys Glu Pro Pro Pro Ala Val Leu Glu Ala Asp Leu Thr Glu Gly Asp 
                165                 170                 175     


Leu Ala Asn Ser His Leu Pro Ser Glu Val Leu Tyr Met Leu Lys Asn 
            180                 185                 190         


Val Arg Val Leu Gly His Phe Glu Lys Pro Leu Phe Leu Glu Leu Cys 
        195                 200                 205             


Arg His Met Val Phe Gln Arg Leu Gly Gln Gly Asp Tyr Val Phe Arg 
    210                 215                 220                 


Pro Gly Gln Pro Asp Ala Ser Ile Tyr Val Val Gln Asp Gly Leu Leu 
225                 230                 235                 240 


Glu Leu Cys Leu Pro Gly Pro Asp Gly Lys Glu Cys Val Val Lys Glu 
                245                 250                 255     


Val Val Pro Gly Asp Ser Val Asn Ser Leu Leu Ser Ile Leu Asp Val 
            260                 265                 270         


Ile Thr Gly His Gln His Pro Gln Arg Thr Val Ser Ala Arg Ala Ala 
        275                 280                 285             


Arg Asp Ser Thr Val Leu Arg Leu Pro Val Glu Ala Phe Ser Ala Val 
    290                 295                 300                 


Phe Thr Lys Tyr Pro Glu Ser Leu Val Arg Val Val Gln Ile Ile Met 
305                 310                 315                 320 


Val Arg Leu Gln Arg Val Thr Phe Leu Ala Leu His Asn Tyr Leu Gly 
                325                 330                 335     


Leu Thr Asn Glu Leu Phe Ser His Glu Ile Gln Pro Leu Arg Leu Phe 
            340                 345                 350         


Pro Ser Pro Gly Leu Pro Thr Arg Thr Ser Pro Val Arg Gly Ser Lys 
        355                 360                 365             


Arg Met Val Ser Thr Ser Ala Thr Asp Glu Pro Arg Glu Thr Pro Gly 
    370                 375                 380                 


Arg Pro Pro Asp Pro Thr Gly Ala Pro Leu Pro Gly Pro Thr Gly Asp 
385                 390                 395                 400 


Pro Val Lys Pro Thr Ser Leu Glu Thr Pro Ser Ala Pro Leu Leu Ser 
                405                 410                 415     


Arg Cys Val Ser Met Pro Gly Asp Ile Ser Gly Leu Gln Gly Gly Pro 
            420                 425                 430         


Arg Ser Asp Phe Asp Met Ala Tyr Glu Arg Gly Arg Ile Ser Val Ser 
        435                 440                 445             


Leu Gln Glu Glu Ala Ser Gly Gly Ser Leu Ala Ala Pro Ala Arg Thr 
    450                 455                 460                 


Pro Thr Gln Glu Pro Arg Glu Gln Pro Ala Gly Ala Cys Glu Tyr Ser 
465                 470                 475                 480 


Tyr Cys Glu Asp Glu Ser Ala Thr Gly Gly Cys Pro Phe Gly Pro Tyr 
                485                 490                 495     


Gln Gly Arg Gln Thr Ser Ser Ile Phe Glu Ala Ala Lys Gln Glu Leu 
            500                 505                 510         


Ala Lys Leu Met Arg Ile Glu Asp Pro Ser Leu Leu Asn Ser Arg Val 
        515                 520                 525             


Leu Leu His His Ala Lys Ala Gly Thr Ile Ile Ala Arg Gln Gly Asp 
    530                 535                 540                 


Gln Asp Val Ser Leu His Phe Val Leu Trp Gly Cys Leu His Val Tyr 
545                 550                 555                 560 


Gln Arg Met Ile Asp Lys Ala Glu Asp Val Cys Leu Phe Val Ala Gln 
                565                 570                 575     


Pro Gly Glu Leu Val Gly Gln Leu Ala Val Leu Thr Gly Glu Pro Leu 
            580                 585                 590         


Ile Phe Thr Leu Arg Ala Gln Arg Asp Cys Thr Phe Leu Arg Ile Ser 
        595                 600                 605             


Lys Ser Asp Phe Tyr Glu Ile Met Arg Ala Gln Pro Ser Val Val Leu 
    610                 615                 620                 


Ser Ala Ala His Thr Val Ala Ala Arg Met Ser Pro Phe Val Arg Gln 
625                 630                 635                 640 


Met Asp Phe Ala Ile Asp Trp Thr Ala Val Glu Ala Gly Arg Ala Leu 
                645                 650                 655     


Tyr Arg Gln Gly Asp Arg Ser Asp Cys Thr Tyr Ile Val Leu Asn Gly 
            660                 665                 670         


Arg Leu Arg Ser Val Ile Gln Arg Gly Ser Gly Lys Lys Glu Leu Val 
        675                 680                 685             


Gly Glu Tyr Gly Arg Gly Asp Leu Ile Gly Val Val Glu Ala Leu Thr 
    690                 695                 700                 


Arg Gln Pro Arg Ala Thr Thr Val His Ala Val Arg Asp Thr Glu Leu 
705                 710                 715                 720 


Ala Lys Leu Pro Glu Gly Thr Leu Gly His Ile Lys Arg Arg Tyr Pro 
                725                 730                 735     


Gln Val Val Thr Arg Leu Ile His Leu Leu Ser Gln Lys Ile Leu Gly 
            740                 745                 750         


Asn Leu Gln Gln Leu Gln Gly Pro Phe Pro Ala Gly Ser Gly Leu Gly 
        755                 760                 765             


Val Pro Pro His Ser Glu Leu Thr Asn Pro Ala Ser Asn Leu Ala Thr 
    770                 775                 780                 


Val Ala Ile Leu Pro Val Cys Ala Glu Val Pro Met Val Ala Phe Thr 
785                 790                 795                 800 


Leu Glu Leu Gln His Ala Leu Gln Ala Ile Gly Pro Thr Leu Leu Leu 
                805                 810                 815     


Asn Ser Asp Ile Ile Arg Ala Arg Leu Gly Ala Ser Ala Leu Asp Ser 
            820                 825                 830         


Ile Gln Glu Phe Arg Leu Ser Gly Trp Leu Ala Gln Gln Glu Asp Ala 
        835                 840                 845             


His Arg Ile Val Leu Tyr Gln Thr Asp Ala Ser Leu Thr Pro Trp Thr 
    850                 855                 860                 


Val Arg Cys Leu Arg Gln Ala Asp Cys Ile Leu Ile Val Gly Leu Gly 
865                 870                 875                 880 


Asp Gln Glu Pro Thr Leu Gly Gln Leu Glu Gln Met Leu Glu Asn Thr 
                885                 890                 895     


Ala Val Arg Ala Leu Lys Gln Leu Val Leu Leu His Arg Glu Glu Gly 
            900                 905                 910         


Ala Gly Pro Thr Arg Thr Val Glu Trp Leu Asn Met Arg Ser Trp Cys 
        915                 920                 925             


Ser Gly His Leu His Leu Arg Cys Pro Arg Arg Leu Phe Ser Arg Arg 
    930                 935                 940                 


Ser Pro Ala Lys Leu His Glu Leu Tyr Glu Lys Val Phe Ser Arg Arg 
945                 950                 955                 960 


Ala Asp Arg His Ser Asp Phe Ser Arg Leu Ala Arg Val Leu Thr Gly 
                965                 970                 975     


Asn Thr Ile Ala Leu Val Leu Gly Gly Gly Gly Ala Arg Gly Cys Ser 
            980                 985                 990         


His Ile Gly Val Leu Lys Ala Leu  Glu Glu Ala Gly Val  Pro Val Asp 
        995                 1000                 1005             


Leu Val  Gly Gly Thr Ser Ile  Gly Ser Phe Ile Gly  Ala Leu Tyr 
    1010                 1015                 1020             


Ala Glu  Glu Arg Ser Ala Ser  Arg Thr Lys Gln Arg  Ala Arg Glu 
    1025                 1030                 1035             


Trp Ala  Lys Ser Met Thr Ser  Val Leu Glu Pro Val  Leu Asp Leu 
    1040                 1045                 1050             


Thr Tyr  Pro Val Thr Ser Met  Phe Thr Gly Ser Ala  Phe Asn Arg 
    1055                 1060                 1065             


Ser Ile  His Arg Val Phe Gln  Asp Lys Gln Ile Glu  Asp Leu Trp 
    1070                 1075                 1080             


Leu Pro  Tyr Phe Asn Val Thr  Thr Asp Ile Thr Ala  Ser Ala Met 
    1085                 1090                 1095             


Arg Val  His Lys Asp Gly Ser  Leu Trp Arg Tyr Val  Arg Ala Ser 
    1100                 1105                 1110             


Met Thr  Leu Ser Gly Tyr Leu  Pro Pro Leu Cys Asp  Pro Lys Asp 
    1115                 1120                 1125             


Gly His  Leu Leu Met Asp Gly  Gly Tyr Ile Asn Asn  Leu Pro Ala 
    1130                 1135                 1140             


Asp Ile  Ala Arg Ser Met Gly  Ala Lys Thr Val Ile  Ala Ile Asp 
    1145                 1150                 1155             


Val Gly  Ser Gln Asp Glu Thr  Asp Leu Ser Thr Tyr  Gly Asp Ser 
    1160                 1165                 1170             


Leu Ser  Gly Trp Trp Leu Leu  Trp Lys Arg Leu Asn  Pro Trp Ala 
    1175                 1180                 1185             


Asp Lys  Val Lys Val Pro Asp  Met Ala Glu Ile Gln  Ser Arg Leu 
    1190                 1195                 1200             


Ala Tyr  Val Ser Cys Val Arg  Gln Leu Glu Val Val  Lys Ser Ser 
    1205                 1210                 1215             


Ser Tyr  Cys Glu Tyr Leu Arg  Pro Pro Ile Asp Cys  Phe Lys Thr 
    1220                 1225                 1230             


Met Asp  Phe Gly Lys Phe Asp  Gln Ile Tyr Asp Val  Gly Tyr Gln 
    1235                 1240                 1245             


Tyr Gly  Lys Ala Val Phe Gly  Gly Trp Ser Arg Gly  Asn Val Ile 
    1250                 1255                 1260             


Glu Lys  Met Leu Thr Asp Arg  Arg Ser Thr Asp Leu  Asn Glu Ser 
    1265                 1270                 1275             


Arg Arg  Ala Asp Val Leu Ala  Phe Pro Ser Ser Gly  Phe Thr Asp 
    1280                 1285                 1290             


Leu Ala  Glu Ile Val Ser Arg  Ile Glu Pro Pro Thr  Ser Tyr Val 
    1295                 1300                 1305             


Ser Asp  Gly Cys Ala Asp Gly  Glu Glu Ser Asp Cys  Leu Thr Glu 
    1310                 1315                 1320             


Tyr Glu  Glu Asp Ala Gly Pro  Asp Cys Ser Arg Asp  Glu Gly Gly 
    1325                 1330                 1335             


Ser Pro  Glu Gly Ala Ser Pro  Ser Thr Ala Ser Glu  Met Glu Glu 
    1340                 1345                 1350             


Glu Lys  Ser Ile Leu Arg Gln  Arg Arg Cys Leu Pro  Gln Glu Pro 
    1355                 1360                 1365             


Pro Gly  Ser Ala Thr Asp Ala  
    1370                 1375 


<210>  2147
<211>  1300
<212>  PRT
<213>  Homo sapiens

<400>  2147

Met Glu Ala Pro Leu Gln Thr Gly Met Val Leu Gly Val Met Ile Gly 
1               5                   10                  15      


Ala Gly Val Ala Val Val Val Thr Ala Val Leu Ile Leu Leu Val Val 
            20                  25                  30          


Arg Arg Leu Arg Val Pro Lys Thr Pro Ala Pro Asp Gly Pro Arg Tyr 
        35                  40                  45              


Arg Phe Arg Lys Arg Asp Lys Val Leu Phe Tyr Gly Arg Lys Ile Met 
    50                  55                  60                  


Arg Lys Val Ser Gln Ser Thr Ser Ser Leu Val Asp Thr Ser Val Ser 
65                  70                  75                  80  


Ala Thr Ser Arg Pro Arg Met Arg Lys Lys Leu Lys Met Leu Asn Ile 
                85                  90                  95      


Ala Lys Lys Ile Leu Arg Ile Gln Lys Glu Thr Pro Thr Leu Gln Arg 
            100                 105                 110         


Lys Glu Pro Pro Pro Ala Val Leu Glu Ala Asp Leu Thr Glu Gly Asp 
        115                 120                 125             


Leu Ala Asn Ser His Leu Pro Ser Glu Val Leu Tyr Met Leu Lys Asn 
    130                 135                 140                 


Val Arg Val Leu Gly His Phe Glu Lys Pro Leu Phe Leu Glu Leu Cys 
145                 150                 155                 160 


Arg His Met Val Phe Gln Arg Leu Gly Gln Gly Asp Tyr Val Phe Arg 
                165                 170                 175     


Pro Gly Gln Pro Asp Ala Ser Ile Tyr Val Val Gln Asp Gly Leu Leu 
            180                 185                 190         


Glu Leu Cys Leu Pro Gly Pro Asp Gly Lys Glu Cys Val Val Lys Glu 
        195                 200                 205             


Val Val Pro Gly Asp Ser Val Asn Ser Leu Leu Ser Ile Leu Asp Val 
    210                 215                 220                 


Ile Thr Gly His Gln His Pro Gln Arg Thr Val Ser Ala Arg Ala Ala 
225                 230                 235                 240 


Arg Asp Ser Thr Val Leu Arg Leu Pro Val Glu Ala Phe Ser Ala Val 
                245                 250                 255     


Phe Thr Lys Tyr Pro Glu Ser Leu Val Arg Val Val Gln Ile Ile Met 
            260                 265                 270         


Val Arg Leu Gln Arg Val Thr Phe Leu Ala Leu His Asn Tyr Leu Gly 
        275                 280                 285             


Leu Thr Asn Glu Leu Phe Ser His Glu Ile Gln Pro Leu Arg Leu Phe 
    290                 295                 300                 


Pro Ser Pro Gly Leu Pro Thr Arg Thr Ser Pro Val Arg Gly Ser Lys 
305                 310                 315                 320 


Arg Met Val Ser Thr Ser Ala Thr Asp Glu Pro Arg Glu Thr Pro Gly 
                325                 330                 335     


Arg Pro Pro Asp Pro Thr Gly Ala Pro Leu Pro Gly Pro Thr Gly Asp 
            340                 345                 350         


Pro Val Lys Pro Thr Ser Leu Glu Thr Pro Ser Ala Pro Leu Leu Ser 
        355                 360                 365             


Arg Cys Val Ser Met Pro Gly Asp Ile Ser Gly Leu Gln Gly Gly Pro 
    370                 375                 380                 


Arg Ser Asp Phe Asp Met Ala Tyr Glu Arg Gly Arg Ile Ser Val Ser 
385                 390                 395                 400 


Leu Gln Glu Glu Ala Ser Gly Gly Ser Leu Ala Ala Pro Ala Arg Thr 
                405                 410                 415     


Pro Thr Gln Glu Pro Arg Glu Gln Pro Ala Gly Ala Cys Glu Tyr Ser 
            420                 425                 430         


Tyr Cys Glu Asp Glu Ser Ala Thr Gly Gly Cys Pro Phe Gly Pro Tyr 
        435                 440                 445             


Gln Gly Arg Gln Thr Ser Ser Ile Phe Glu Ala Ala Lys Gln Glu Leu 
    450                 455                 460                 


Ala Lys Leu Met Arg Ile Glu Asp Val Ser Leu His Phe Val Leu Trp 
465                 470                 475                 480 


Gly Cys Leu His Val Tyr Gln Arg Met Ile Asp Lys Ala Glu Asp Val 
                485                 490                 495     


Cys Leu Phe Val Ala Gln Pro Gly Glu Leu Val Gly Gln Leu Ala Val 
            500                 505                 510         


Leu Thr Gly Glu Pro Leu Ile Phe Thr Leu Arg Ala Gln Arg Asp Cys 
        515                 520                 525             


Thr Phe Leu Arg Ile Ser Lys Ser Asp Phe Tyr Glu Ile Met Arg Ala 
    530                 535                 540                 


Gln Pro Ser Val Val Leu Ser Ala Ala His Thr Val Ala Ala Arg Met 
545                 550                 555                 560 


Ser Pro Phe Val Arg Gln Met Asp Phe Ala Ile Asp Trp Thr Ala Val 
                565                 570                 575     


Glu Ala Gly Arg Ala Leu Tyr Arg Gln Gly Asp Arg Ser Asp Cys Thr 
            580                 585                 590         


Tyr Ile Val Leu Asn Gly Arg Leu Arg Ser Val Ile Gln Arg Gly Ser 
        595                 600                 605             


Gly Lys Lys Glu Leu Val Gly Glu Tyr Gly Arg Gly Asp Leu Ile Gly 
    610                 615                 620                 


Val Val Glu Ala Leu Thr Arg Gln Pro Arg Ala Thr Thr Val His Ala 
625                 630                 635                 640 


Val Arg Asp Thr Glu Leu Ala Lys Leu Pro Glu Gly Thr Leu Gly His 
                645                 650                 655     


Ile Lys Arg Arg Tyr Pro Gln Val Val Thr Arg Leu Ile His Leu Leu 
            660                 665                 670         


Ser Gln Lys Ile Leu Gly Asn Leu Gln Gln Leu Gln Gly Pro Phe Pro 
        675                 680                 685             


Gly Ser Gly Leu Gly Val Pro Pro His Ser Glu Leu Thr Asn Pro Ala 
    690                 695                 700                 


Ser Asn Leu Ala Thr Val Ala Ile Leu Pro Val Cys Ala Glu Val Pro 
705                 710                 715                 720 


Met Val Ala Phe Thr Leu Glu Leu Gln His Ala Leu Gln Ala Ile Gly 
                725                 730                 735     


Pro Thr Leu Leu Leu Asn Ser Asp Ile Ile Arg Ala Arg Leu Gly Ala 
            740                 745                 750         


Ser Ala Leu Asp Ser Ile Gln Glu Phe Arg Leu Ser Gly Trp Leu Ala 
        755                 760                 765             


Gln Gln Glu Asp Ala His Arg Ile Val Leu Tyr Gln Thr Asp Ala Ser 
    770                 775                 780                 


Leu Thr Pro Trp Thr Val Arg Cys Leu Arg Gln Ala Asp Cys Ile Leu 
785                 790                 795                 800 


Ile Val Gly Leu Gly Asp Gln Glu Pro Thr Leu Gly Gln Leu Glu Gln 
                805                 810                 815     


Met Leu Glu Asn Thr Ala Val Arg Ala Leu Lys Gln Leu Val Leu Leu 
            820                 825                 830         


His Arg Glu Glu Gly Ala Gly Pro Thr Arg Thr Val Glu Trp Leu Asn 
        835                 840                 845             


Met Arg Ser Trp Cys Ser Gly His Leu His Leu Arg Cys Pro Arg Arg 
    850                 855                 860                 


Leu Phe Ser Arg Arg Ser Pro Ala Lys Leu His Glu Leu Tyr Glu Lys 
865                 870                 875                 880 


Val Phe Ser Arg Arg Ala Asp Arg His Ser Asp Phe Ser Arg Leu Ala 
                885                 890                 895     


Arg Val Leu Thr Gly Asn Thr Ile Ala Leu Val Leu Gly Gly Gly Gly 
            900                 905                 910         


Ala Arg Gly Cys Ser His Ile Gly Val Leu Lys Ala Leu Glu Glu Ala 
        915                 920                 925             


Gly Val Pro Val Asp Leu Val Gly Gly Thr Ser Ile Gly Ser Phe Ile 
    930                 935                 940                 


Gly Ala Leu Tyr Ala Glu Glu Arg Ser Ala Ser Arg Thr Lys Gln Arg 
945                 950                 955                 960 


Ala Arg Glu Trp Ala Lys Ser Met Thr Ser Val Leu Glu Pro Val Leu 
                965                 970                 975     


Asp Leu Thr Tyr Pro Val Thr Ser Met Phe Thr Gly Ser Ala Phe Asn 
            980                 985                 990         


Arg Ser Ile His Arg Val Phe Gln  Asp Lys Gln Ile Glu  Asp Leu Trp 
        995                 1000                 1005             


Leu Pro  Tyr Phe Asn Val Thr  Thr Asp Ile Thr Ala  Ser Ala Met 
    1010                 1015                 1020             


Arg Val  His Lys Asp Gly Ser  Leu Trp Arg Tyr Val  Arg Ala Ser 
    1025                 1030                 1035             


Met Thr  Leu Ser Gly Tyr Leu  Pro Pro Leu Cys Asp  Pro Lys Asp 
    1040                 1045                 1050             


Gly His  Leu Leu Met Asp Gly  Gly Tyr Ile Asn Asn  Leu Pro Ala 
    1055                 1060                 1065             


Asp Ile  Ala Arg Ser Met Gly  Ala Lys Thr Val Ile  Ala Ile Asp 
    1070                 1075                 1080             


Val Gly  Ser Gln Asp Glu Thr  Asp Leu Ser Thr Tyr  Gly Asp Ser 
    1085                 1090                 1095             


Leu Ser  Gly Trp Trp Leu Leu  Trp Lys Arg Leu Asn  Pro Trp Ala 
    1100                 1105                 1110             


Asp Lys  Val Lys Val Pro Asp  Met Ala Glu Ile Gln  Ser Arg Leu 
    1115                 1120                 1125             


Ala Tyr  Val Ser Cys Val Arg  Gln Leu Glu Val Val  Lys Ser Ser 
    1130                 1135                 1140             


Ser Tyr  Cys Glu Tyr Leu Arg  Pro Pro Ile Asp Cys  Phe Lys Thr 
    1145                 1150                 1155             


Met Asp  Phe Gly Lys Phe Asp  Gln Ile Tyr Asp Val  Gly Tyr Gln 
    1160                 1165                 1170             


Tyr Gly  Lys Ala Val Phe Gly  Gly Trp Ser Arg Gly  Asn Val Ile 
    1175                 1180                 1185             


Glu Lys  Met Leu Thr Asp Arg  Arg Ser Thr Asp Leu  Asn Glu Ser 
    1190                 1195                 1200             


Arg Arg  Ala Asp Val Leu Ala  Phe Pro Ser Ser Gly  Phe Thr Asp 
    1205                 1210                 1215             


Leu Ala  Glu Ile Val Ser Arg  Ile Glu Pro Pro Thr  Ser Tyr Val 
    1220                 1225                 1230             


Ser Asp  Gly Cys Ala Asp Gly  Glu Glu Ser Asp Cys  Leu Thr Glu 
    1235                 1240                 1245             


Tyr Glu  Glu Asp Ala Gly Pro  Asp Cys Ser Arg Asp  Glu Gly Gly 
    1250                 1255                 1260             


Ser Pro  Glu Gly Ala Ser Pro  Ser Thr Ala Ser Glu  Met Glu Glu 
    1265                 1270                 1275             


Glu Lys  Ser Ile Leu Arg Gln  Arg Arg Cys Leu Pro  Gln Glu Pro 
    1280                 1285                 1290             


Pro Gly  Ser Ala Thr Asp Ala  
    1295                 1300 


<210>  2148
<211>  1327
<212>  PRT
<213>  Homo sapiens

<400>  2148

Met Glu Ala Pro Leu Gln Thr Gly Met Val Leu Gly Val Met Ile Gly 
1               5                   10                  15      


Ala Gly Val Ala Val Val Val Thr Ala Val Leu Ile Leu Leu Val Val 
            20                  25                  30          


Arg Arg Leu Arg Val Pro Lys Thr Pro Ala Pro Asp Gly Pro Arg Tyr 
        35                  40                  45              


Arg Phe Arg Lys Arg Asp Lys Val Leu Phe Tyr Gly Arg Lys Ile Met 
    50                  55                  60                  


Arg Lys Val Ser Gln Ser Thr Ser Ser Leu Val Asp Thr Ser Val Ser 
65                  70                  75                  80  


Ala Thr Ser Arg Pro Arg Met Arg Lys Lys Leu Lys Met Leu Asn Ile 
                85                  90                  95      


Ala Lys Lys Ile Leu Arg Ile Gln Lys Glu Thr Pro Thr Leu Gln Arg 
            100                 105                 110         


Lys Glu Pro Pro Pro Ala Val Leu Glu Ala Asp Leu Thr Glu Gly Asp 
        115                 120                 125             


Leu Ala Asn Ser His Leu Pro Ser Glu Val Leu Tyr Met Leu Lys Asn 
    130                 135                 140                 


Val Arg Val Leu Gly His Phe Glu Lys Pro Leu Phe Leu Glu Leu Cys 
145                 150                 155                 160 


Arg His Met Val Phe Gln Arg Leu Gly Gln Gly Asp Tyr Val Phe Arg 
                165                 170                 175     


Pro Gly Gln Pro Asp Ala Ser Ile Tyr Val Val Gln Asp Gly Leu Leu 
            180                 185                 190         


Glu Leu Cys Leu Pro Gly Pro Asp Gly Lys Glu Cys Val Val Lys Glu 
        195                 200                 205             


Val Val Pro Gly Asp Ser Val Asn Ser Leu Leu Ser Ile Leu Asp Val 
    210                 215                 220                 


Ile Thr Gly His Gln His Pro Gln Arg Thr Val Ser Ala Arg Ala Ala 
225                 230                 235                 240 


Arg Asp Ser Thr Val Leu Arg Leu Pro Val Glu Ala Phe Ser Ala Val 
                245                 250                 255     


Phe Thr Lys Tyr Pro Glu Ser Leu Val Arg Val Val Gln Ile Ile Met 
            260                 265                 270         


Val Arg Leu Gln Arg Val Thr Phe Leu Ala Leu His Asn Tyr Leu Gly 
        275                 280                 285             


Leu Thr Asn Glu Leu Phe Ser His Glu Ile Gln Pro Leu Arg Leu Phe 
    290                 295                 300                 


Pro Ser Pro Gly Leu Pro Thr Arg Thr Ser Pro Val Arg Gly Ser Lys 
305                 310                 315                 320 


Arg Met Val Ser Thr Ser Ala Thr Asp Glu Pro Arg Glu Thr Pro Gly 
                325                 330                 335     


Arg Pro Pro Asp Pro Thr Gly Ala Pro Leu Pro Gly Pro Thr Gly Asp 
            340                 345                 350         


Pro Val Lys Pro Thr Ser Leu Glu Thr Pro Ser Ala Pro Leu Leu Ser 
        355                 360                 365             


Arg Cys Val Ser Met Pro Gly Asp Ile Ser Gly Leu Gln Gly Gly Pro 
    370                 375                 380                 


Arg Ser Asp Phe Asp Met Ala Tyr Glu Arg Gly Arg Ile Ser Val Ser 
385                 390                 395                 400 


Leu Gln Glu Glu Ala Ser Gly Gly Ser Leu Ala Ala Pro Ala Arg Thr 
                405                 410                 415     


Pro Thr Gln Glu Pro Arg Glu Gln Pro Ala Gly Ala Cys Glu Tyr Ser 
            420                 425                 430         


Tyr Cys Glu Asp Glu Ser Ala Thr Gly Gly Cys Pro Phe Gly Pro Tyr 
        435                 440                 445             


Gln Gly Arg Gln Thr Ser Ser Ile Phe Glu Ala Ala Lys Gln Glu Leu 
    450                 455                 460                 


Ala Lys Leu Met Arg Ile Glu Asp Pro Ser Leu Leu Asn Ser Arg Val 
465                 470                 475                 480 


Leu Leu His His Ala Lys Ala Gly Thr Ile Ile Ala Arg Gln Gly Asp 
                485                 490                 495     


Gln Asp Val Ser Leu His Phe Val Leu Trp Gly Cys Leu His Val Tyr 
            500                 505                 510         


Gln Arg Met Ile Asp Lys Ala Glu Asp Val Cys Leu Phe Val Ala Gln 
        515                 520                 525             


Pro Gly Glu Leu Val Gly Gln Leu Ala Val Leu Thr Gly Glu Pro Leu 
    530                 535                 540                 


Ile Phe Thr Leu Arg Ala Gln Arg Asp Cys Thr Phe Leu Arg Ile Ser 
545                 550                 555                 560 


Lys Ser Asp Phe Tyr Glu Ile Met Arg Ala Gln Pro Ser Val Val Leu 
                565                 570                 575     


Ser Ala Ala His Thr Val Ala Ala Arg Met Ser Pro Phe Val Arg Gln 
            580                 585                 590         


Met Asp Phe Ala Ile Asp Trp Thr Ala Val Glu Ala Gly Arg Ala Leu 
        595                 600                 605             


Tyr Arg Gln Gly Asp Arg Ser Asp Cys Thr Tyr Ile Val Leu Asn Gly 
    610                 615                 620                 


Arg Leu Arg Ser Val Ile Gln Arg Gly Ser Gly Lys Lys Glu Leu Val 
625                 630                 635                 640 


Gly Glu Tyr Gly Arg Gly Asp Leu Ile Gly Val Val Glu Ala Leu Thr 
                645                 650                 655     


Arg Gln Pro Arg Ala Thr Thr Val His Ala Val Arg Asp Thr Glu Leu 
            660                 665                 670         


Ala Lys Leu Pro Glu Gly Thr Leu Gly His Ile Lys Arg Arg Tyr Pro 
        675                 680                 685             


Gln Val Val Thr Arg Leu Ile His Leu Leu Ser Gln Lys Ile Leu Gly 
    690                 695                 700                 


Asn Leu Gln Gln Leu Gln Gly Pro Phe Pro Ala Gly Ser Gly Leu Gly 
705                 710                 715                 720 


Val Pro Pro His Ser Glu Leu Thr Asn Pro Ala Ser Asn Leu Ala Thr 
                725                 730                 735     


Val Ala Ile Leu Pro Val Cys Ala Glu Val Pro Met Val Ala Phe Thr 
            740                 745                 750         


Leu Glu Leu Gln His Ala Leu Gln Ala Ile Gly Pro Thr Leu Leu Leu 
        755                 760                 765             


Asn Ser Asp Ile Ile Arg Ala Arg Leu Gly Ala Ser Ala Leu Asp Ser 
    770                 775                 780                 


Ile Gln Glu Phe Arg Leu Ser Gly Trp Leu Ala Gln Gln Glu Asp Ala 
785                 790                 795                 800 


His Arg Ile Val Leu Tyr Gln Thr Asp Ala Ser Leu Thr Pro Trp Thr 
                805                 810                 815     


Val Arg Cys Leu Arg Gln Ala Asp Cys Ile Leu Ile Val Gly Leu Gly 
            820                 825                 830         


Asp Gln Glu Pro Thr Leu Gly Gln Leu Glu Gln Met Leu Glu Asn Thr 
        835                 840                 845             


Ala Val Arg Ala Leu Lys Gln Leu Val Leu Leu His Arg Glu Glu Gly 
    850                 855                 860                 


Ala Gly Pro Thr Arg Thr Val Glu Trp Leu Asn Met Arg Ser Trp Cys 
865                 870                 875                 880 


Ser Gly His Leu His Leu Arg Cys Pro Arg Arg Leu Phe Ser Arg Arg 
                885                 890                 895     


Ser Pro Ala Lys Leu His Glu Leu Tyr Glu Lys Val Phe Ser Arg Arg 
            900                 905                 910         


Ala Asp Arg His Ser Asp Phe Ser Arg Leu Ala Arg Val Leu Thr Gly 
        915                 920                 925             


Asn Thr Ile Ala Leu Val Leu Gly Gly Gly Gly Ala Arg Gly Cys Ser 
    930                 935                 940                 


His Ile Gly Val Leu Lys Ala Leu Glu Glu Ala Gly Val Pro Val Asp 
945                 950                 955                 960 


Leu Val Gly Gly Thr Ser Ile Gly Ser Phe Ile Gly Ala Leu Tyr Ala 
                965                 970                 975     


Glu Glu Arg Ser Ala Ser Arg Thr Lys Gln Arg Ala Arg Glu Trp Ala 
            980                 985                 990         


Lys Ser Met Thr Ser Val Leu Glu  Pro Val Leu Asp Leu  Thr Tyr Pro 
        995                 1000                 1005             


Val Thr  Ser Met Phe Thr Gly  Ser Ala Phe Asn Arg  Ser Ile His 
    1010                 1015                 1020             


Arg Val  Phe Gln Asp Lys Gln  Ile Glu Asp Leu Trp  Leu Pro Tyr 
    1025                 1030                 1035             


Phe Asn  Val Thr Thr Asp Ile  Thr Ala Ser Ala Met  Arg Val His 
    1040                 1045                 1050             


Lys Asp  Gly Ser Leu Trp Arg  Tyr Val Arg Ala Ser  Met Thr Leu 
    1055                 1060                 1065             


Ser Gly  Tyr Leu Pro Pro Leu  Cys Asp Pro Lys Asp  Gly His Leu 
    1070                 1075                 1080             


Leu Met  Asp Gly Gly Tyr Ile  Asn Asn Leu Pro Ala  Asp Ile Ala 
    1085                 1090                 1095             


Arg Ser  Met Gly Ala Lys Thr  Val Ile Ala Ile Asp  Val Gly Ser 
    1100                 1105                 1110             


Gln Asp  Glu Thr Asp Leu Ser  Thr Tyr Gly Asp Ser  Leu Ser Gly 
    1115                 1120                 1125             


Trp Trp  Leu Leu Trp Lys Arg  Leu Asn Pro Trp Ala  Asp Lys Val 
    1130                 1135                 1140             


Lys Val  Pro Asp Met Ala Glu  Ile Gln Ser Arg Leu  Ala Tyr Val 
    1145                 1150                 1155             


Ser Cys  Val Arg Gln Leu Glu  Val Val Lys Ser Ser  Ser Tyr Cys 
    1160                 1165                 1170             


Glu Tyr  Leu Arg Pro Pro Ile  Asp Cys Phe Lys Thr  Met Asp Phe 
    1175                 1180                 1185             


Gly Lys  Phe Asp Gln Ile Tyr  Asp Val Gly Tyr Gln  Tyr Gly Lys 
    1190                 1195                 1200             


Ala Val  Phe Gly Gly Trp Ser  Arg Gly Asn Val Ile  Glu Lys Met 
    1205                 1210                 1215             


Leu Thr  Asp Arg Arg Ser Thr  Asp Leu Asn Glu Ser  Arg Arg Ala 
    1220                 1225                 1230             


Asp Val  Leu Ala Phe Pro Ser  Ser Gly Phe Thr Asp  Leu Ala Glu 
    1235                 1240                 1245             


Ile Val  Ser Arg Ile Glu Pro  Pro Thr Ser Tyr Val  Ser Asp Gly 
    1250                 1255                 1260             


Cys Ala  Asp Gly Glu Glu Ser  Asp Cys Leu Thr Glu  Tyr Glu Glu 
    1265                 1270                 1275             


Asp Ala  Gly Pro Asp Cys Ser  Arg Asp Glu Gly Gly  Ser Pro Glu 
    1280                 1285                 1290             


Gly Ala  Ser Pro Ser Thr Ala  Ser Glu Met Glu Glu  Glu Lys Ser 
    1295                 1300                 1305             


Ile Leu  Arg Gln Arg Arg Cys  Leu Pro Gln Glu Pro  Pro Gly Ser 
    1310                 1315                 1320             


Ala Thr  Asp Ala 
    1325         


<210>  2149
<211>  1365
<212>  PRT
<213>  Homo sapiens

<400>  2149

Met Gly Thr Ser Ser His Gly Leu Ala Thr Asn Ser Ser Gly Ala Lys 
1               5                   10                  15      


Val Ala Glu Arg Asp Gly Phe Gln Asp Val Leu Ala Pro Gly Glu Gly 
            20                  25                  30          


Ser Ala Gly Arg Ile Cys Gly Ala Gln Pro Val Pro Phe Val Pro Gln 
        35                  40                  45              


Val Leu Gly Val Met Ile Gly Ala Gly Val Ala Val Val Val Thr Ala 
    50                  55                  60                  


Val Leu Ile Leu Leu Val Val Arg Arg Leu Arg Val Pro Lys Thr Pro 
65                  70                  75                  80  


Ala Pro Asp Gly Pro Arg Tyr Arg Phe Arg Lys Arg Asp Lys Val Leu 
                85                  90                  95      


Phe Tyr Gly Arg Lys Ile Met Arg Lys Val Ser Gln Ser Thr Ser Ser 
            100                 105                 110         


Leu Val Asp Thr Ser Val Ser Ala Thr Ser Arg Pro Arg Met Arg Lys 
        115                 120                 125             


Lys Leu Lys Met Leu Asn Ile Ala Lys Lys Ile Leu Arg Ile Gln Lys 
    130                 135                 140                 


Glu Thr Pro Thr Leu Gln Arg Lys Glu Pro Pro Pro Ala Val Leu Glu 
145                 150                 155                 160 


Ala Asp Leu Thr Glu Gly Asp Leu Ala Asn Ser His Leu Pro Ser Glu 
                165                 170                 175     


Val Leu Tyr Met Leu Lys Asn Val Arg Val Leu Gly His Phe Glu Lys 
            180                 185                 190         


Pro Leu Phe Leu Glu Leu Cys Arg His Met Val Phe Gln Arg Leu Gly 
        195                 200                 205             


Gln Gly Asp Tyr Val Phe Arg Pro Gly Gln Pro Asp Ala Ser Ile Tyr 
    210                 215                 220                 


Val Val Gln Asp Gly Leu Leu Glu Leu Cys Leu Pro Gly Pro Asp Gly 
225                 230                 235                 240 


Lys Glu Cys Val Val Lys Glu Val Val Pro Gly Asp Ser Val Asn Ser 
                245                 250                 255     


Leu Leu Ser Ile Leu Asp Val Ile Thr Gly His Gln His Pro Gln Arg 
            260                 265                 270         


Thr Val Ser Ala Arg Ala Ala Arg Asp Ser Thr Val Leu Arg Leu Pro 
        275                 280                 285             


Val Glu Ala Phe Ser Ala Val Phe Thr Lys Tyr Pro Glu Ser Leu Val 
    290                 295                 300                 


Arg Val Val Gln Ile Ile Met Val Arg Leu Gln Arg Val Thr Phe Leu 
305                 310                 315                 320 


Ala Leu His Asn Tyr Leu Gly Leu Thr Asn Glu Leu Phe Ser His Glu 
                325                 330                 335     


Ile Gln Pro Leu Arg Leu Phe Pro Ser Pro Gly Leu Pro Thr Arg Thr 
            340                 345                 350         


Ser Pro Val Arg Gly Ser Lys Arg Met Val Ser Thr Ser Ala Thr Asp 
        355                 360                 365             


Glu Pro Arg Glu Thr Pro Gly Arg Pro Pro Asp Pro Thr Gly Ala Pro 
    370                 375                 380                 


Leu Pro Gly Pro Thr Gly Asp Pro Val Lys Pro Thr Ser Leu Glu Thr 
385                 390                 395                 400 


Pro Ser Ala Pro Leu Leu Ser Arg Cys Val Ser Met Pro Gly Asp Ile 
                405                 410                 415     


Ser Gly Leu Gln Gly Gly Pro Arg Ser Asp Phe Asp Met Ala Tyr Glu 
            420                 425                 430         


Arg Gly Arg Ile Ser Val Ser Leu Gln Glu Glu Ala Ser Gly Gly Ser 
        435                 440                 445             


Leu Ala Ala Pro Ala Arg Thr Pro Thr Gln Glu Pro Arg Glu Gln Pro 
    450                 455                 460                 


Ala Gly Ala Cys Glu Tyr Ser Tyr Cys Glu Asp Glu Ser Ala Thr Gly 
465                 470                 475                 480 


Gly Cys Pro Phe Gly Pro Tyr Gln Gly Arg Gln Thr Ser Ser Ile Phe 
                485                 490                 495     


Glu Ala Ala Lys Gln Glu Leu Ala Lys Leu Met Arg Ile Glu Asp Pro 
            500                 505                 510         


Ser Leu Leu Asn Ser Arg Val Leu Leu His His Ala Lys Ala Gly Thr 
        515                 520                 525             


Ile Ile Ala Arg Gln Gly Asp Gln Asp Val Ser Leu His Phe Val Leu 
    530                 535                 540                 


Trp Gly Cys Leu His Val Tyr Gln Arg Met Ile Asp Lys Ala Glu Asp 
545                 550                 555                 560 


Val Cys Leu Phe Val Ala Gln Pro Gly Glu Leu Val Gly Gln Leu Ala 
                565                 570                 575     


Val Leu Thr Gly Glu Pro Leu Ile Phe Thr Leu Arg Ala Gln Arg Asp 
            580                 585                 590         


Cys Thr Phe Leu Arg Ile Ser Lys Ser Asp Phe Tyr Glu Ile Met Arg 
        595                 600                 605             


Ala Gln Pro Ser Val Val Leu Ser Ala Ala His Thr Val Ala Ala Arg 
    610                 615                 620                 


Met Ser Pro Phe Val Arg Gln Met Asp Phe Ala Ile Asp Trp Thr Ala 
625                 630                 635                 640 


Val Glu Ala Gly Arg Ala Leu Tyr Arg Gln Gly Asp Arg Ser Asp Cys 
                645                 650                 655     


Thr Tyr Ile Val Leu Asn Gly Arg Leu Arg Ser Val Ile Gln Arg Gly 
            660                 665                 670         


Ser Gly Lys Lys Glu Leu Val Gly Glu Tyr Gly Arg Gly Asp Leu Ile 
        675                 680                 685             


Gly Val Val Glu Ala Leu Thr Arg Gln Pro Arg Ala Thr Thr Val His 
    690                 695                 700                 


Ala Val Arg Asp Thr Glu Leu Ala Lys Leu Pro Glu Gly Thr Leu Gly 
705                 710                 715                 720 


His Ile Lys Arg Arg Tyr Pro Gln Val Val Thr Arg Leu Ile His Leu 
                725                 730                 735     


Leu Ser Gln Lys Ile Leu Gly Asn Leu Gln Gln Leu Gln Gly Pro Phe 
            740                 745                 750         


Pro Gly Ser Gly Leu Gly Val Pro Pro His Ser Glu Leu Thr Asn Pro 
        755                 760                 765             


Ala Ser Asn Leu Ala Thr Val Ala Ile Leu Pro Val Cys Ala Glu Val 
    770                 775                 780                 


Pro Met Val Ala Phe Thr Leu Glu Leu Gln His Ala Leu Gln Ala Ile 
785                 790                 795                 800 


Gly Pro Thr Leu Leu Leu Asn Ser Asp Ile Ile Arg Ala Arg Leu Gly 
                805                 810                 815     


Ala Ser Ala Leu Asp Ser Ile Gln Glu Phe Arg Leu Ser Gly Trp Leu 
            820                 825                 830         


Ala Gln Gln Glu Asp Ala His Arg Ile Val Leu Tyr Gln Thr Asp Ala 
        835                 840                 845             


Ser Leu Thr Pro Trp Thr Val Arg Cys Leu Arg Gln Ala Asp Cys Ile 
    850                 855                 860                 


Leu Ile Val Gly Leu Gly Asp Gln Glu Pro Thr Leu Gly Gln Leu Glu 
865                 870                 875                 880 


Gln Met Leu Glu Asn Thr Ala Val Arg Ala Leu Lys Gln Leu Val Leu 
                885                 890                 895     


Leu His Arg Glu Glu Gly Ala Gly Pro Thr Arg Thr Val Glu Trp Leu 
            900                 905                 910         


Asn Met Arg Ser Trp Cys Ser Gly His Leu His Leu Arg Cys Pro Arg 
        915                 920                 925             


Arg Leu Phe Ser Arg Arg Ser Pro Ala Lys Leu His Glu Leu Tyr Glu 
    930                 935                 940                 


Lys Val Phe Ser Arg Arg Ala Asp Arg His Ser Asp Phe Ser Arg Leu 
945                 950                 955                 960 


Ala Arg Val Leu Thr Gly Asn Thr Ile Ala Leu Val Leu Gly Gly Gly 
                965                 970                 975     


Gly Ala Arg Gly Cys Ser His Ile Gly Val Leu Lys Ala Leu Glu Glu 
            980                 985                 990         


Ala Gly Val Pro Val Asp Leu Val  Gly Gly Thr Ser Ile  Gly Ser Phe 
        995                 1000                 1005             


Ile Gly  Ala Leu Tyr Ala Glu  Glu Arg Ser Ala Ser  Arg Thr Lys 
    1010                 1015                 1020             


Gln Arg  Ala Arg Glu Trp Ala  Lys Ser Met Thr Ser  Val Leu Glu 
    1025                 1030                 1035             


Pro Val  Leu Asp Leu Thr Tyr  Pro Val Thr Ser Met  Phe Thr Gly 
    1040                 1045                 1050             


Ser Ala  Phe Asn Arg Ser Ile  His Arg Val Phe Gln  Asp Lys Gln 
    1055                 1060                 1065             


Ile Glu  Asp Leu Trp Leu Pro  Tyr Phe Asn Val Thr  Thr Asp Ile 
    1070                 1075                 1080             


Thr Ala  Ser Ala Met Arg Val  His Lys Asp Gly Ser  Leu Trp Arg 
    1085                 1090                 1095             


Tyr Val  Arg Ala Ser Met Thr  Leu Ser Gly Tyr Leu  Pro Pro Leu 
    1100                 1105                 1110             


Cys Asp  Pro Lys Asp Gly His  Leu Leu Met Asp Gly  Gly Tyr Ile 
    1115                 1120                 1125             


Asn Asn  Leu Pro Ala Asp Ile  Ala Arg Ser Met Gly  Ala Lys Thr 
    1130                 1135                 1140             


Val Ile  Ala Ile Asp Val Gly  Ser Gln Asp Glu Thr  Asp Leu Ser 
    1145                 1150                 1155             


Thr Tyr  Gly Asp Ser Leu Ser  Gly Trp Trp Leu Leu  Trp Lys Arg 
    1160                 1165                 1170             


Leu Asn  Pro Trp Ala Asp Lys  Val Lys Val Pro Asp  Met Ala Glu 
    1175                 1180                 1185             


Ile Gln  Ser Arg Leu Ala Tyr  Val Ser Cys Val Arg  Gln Leu Glu 
    1190                 1195                 1200             


Val Val  Lys Ser Ser Ser Tyr  Cys Glu Tyr Leu Arg  Pro Pro Ile 
    1205                 1210                 1215             


Asp Cys  Phe Lys Thr Met Asp  Phe Gly Lys Phe Asp  Gln Ile Tyr 
    1220                 1225                 1230             


Asp Val  Gly Tyr Gln Tyr Gly  Lys Ala Val Phe Gly  Gly Trp Ser 
    1235                 1240                 1245             


Arg Gly  Asn Val Ile Glu Lys  Met Leu Thr Asp Arg  Arg Ser Thr 
    1250                 1255                 1260             


Asp Leu  Asn Glu Ser Arg Arg  Ala Asp Val Leu Ala  Phe Pro Ser 
    1265                 1270                 1275             


Ser Gly  Phe Thr Asp Leu Ala  Glu Ile Val Ser Arg  Ile Glu Pro 
    1280                 1285                 1290             


Pro Thr  Ser Tyr Val Ser Asp  Gly Cys Ala Asp Gly  Glu Glu Ser 
    1295                 1300                 1305             


Asp Cys  Leu Thr Glu Tyr Glu  Glu Asp Ala Gly Pro  Asp Cys Ser 
    1310                 1315                 1320             


Arg Asp  Glu Gly Gly Ser Pro  Glu Gly Ala Ser Pro  Ser Thr Ala 
    1325                 1330                 1335             


Ser Glu  Met Glu Glu Glu Lys  Ser Ile Leu Arg Gln  Arg Arg Cys 
    1340                 1345                 1350             


Leu Pro  Gln Glu Pro Pro Gly  Ser Ala Thr Asp Ala  
    1355                 1360                 1365 


<210>  2150
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  2150

Met Pro Glu Phe Gln Lys Ser Ser Val Arg Ile Lys Asn Pro Thr Arg 
1               5                   10                  15      


Val Glu Glu Ile Ile Cys Gly Leu Ile Lys Gly Gly Ala Ala Lys Leu 
            20                  25                  30          


Gln Ile Ile Thr Asp Phe Asp Met Thr Leu Ser Arg Phe Ser Tyr Lys 
        35                  40                  45              


Gly Lys Arg Cys Pro Thr Cys His Asn Ile Ile Asp Asn Cys Lys Leu 
    50                  55                  60                  


Val Thr Asp Glu Cys Arg Lys Lys Leu Leu Gln Leu Lys Glu Lys Tyr 
65                  70                  75                  80  


Tyr Ala Ile Glu Val Asp Pro Val Leu Thr Val Glu Glu Lys Tyr Pro 
                85                  90                  95      


Tyr Met Val Glu Trp Tyr Thr Lys Ser His Gly Leu Leu Val Gln Gln 
            100                 105                 110         


Ala Leu Pro Lys Ala Lys Leu Lys Glu Ile Val Ala Glu Ser Asp Val 
        115                 120                 125             


Met Leu Lys Glu Gly Tyr Glu Asn Phe Phe Asp Lys Leu Gln Gln His 
    130                 135                 140                 


Ser Ile Pro Val Phe Ile Phe Ser Ala Gly Ile Gly Asp Val Leu Glu 
145                 150                 155                 160 


Glu Val Ile Arg Gln Ala Gly Val Tyr His Pro Asn Val Lys Val Val 
                165                 170                 175     


Ser Asn Phe Met Asp Phe Asp Glu Thr Gly Val Leu Lys Gly Phe Lys 
            180                 185                 190         


Gly Glu Leu Ile His Val Phe Asn Lys His Asp Gly Ala Leu Arg Asn 
        195                 200                 205             


Thr Glu Tyr Phe Asn Gln Leu Lys Asp Asn Ser Asn Ile Ile Leu Leu 
    210                 215                 220                 


Gly Asp Ser Gln Gly Asp Leu Arg Met Ala Asp Gly Val Ala Asn Val 
225                 230                 235                 240 


Glu His Ile Leu Lys Ile Gly Tyr Leu Asn Asp Arg Val Asp Glu Leu 
                245                 250                 255     


Leu Glu Lys Tyr Met Asp Ser Tyr Asp Ile Val Leu Val Gln Asp Glu 
            260                 265                 270         


Ser Leu Glu Val Ala Asn Ser Ile Leu Gln Lys Ile Leu 
        275                 280                 285 


<210>  2151
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  2151

Met Gly Trp Ser Cys Leu Val Thr Gly Ala Gly Gly Leu Leu Gly Gln 
1               5                   10                  15      


Arg Ile Val Arg Leu Leu Val Glu Glu Lys Glu Leu Lys Glu Ile Arg 
            20                  25                  30          


Ala Leu Asp Lys Ala Phe Arg Pro Glu Leu Arg Glu Glu Phe Ser Lys 
        35                  40                  45              


Leu Gln Asn Arg Thr Lys Leu Thr Val Leu Glu Gly Asp Ile Leu Asp 
    50                  55                  60                  


Glu Pro Phe Leu Lys Arg Ala Cys Gln Asp Val Ser Val Val Ile His 
65                  70                  75                  80  


Thr Ala Cys Ile Ile Asp Val Phe Gly Val Thr His Arg Glu Ser Ile 
                85                  90                  95      


Met Asn Val Asn Val Lys Gly Thr Gln Leu Leu Leu Glu Ala Cys Val 
            100                 105                 110         


Gln Ala Ser Val Pro Val Phe Ile Tyr Thr Ser Ser Ile Glu Val Ala 
        115                 120                 125             


Gly Pro Asn Ser Tyr Lys Glu Ile Ile Gln Asn Gly His Glu Glu Glu 
    130                 135                 140                 


Pro Leu Glu Asn Thr Trp Pro Thr Pro Tyr Pro Tyr Ser Lys Lys Leu 
145                 150                 155                 160 


Ala Glu Lys Ala Val Leu Ala Ala Asn Gly Trp Asn Leu Lys Asn Gly 
                165                 170                 175     


Asp Thr Leu Tyr Thr Cys Ala Leu Arg Pro Thr Tyr Ile Tyr Gly Glu 
            180                 185                 190         


Gly Gly Pro Phe Leu Ser Ala Ser Ile Asn Glu Ala Leu Asn Asn Asn 
        195                 200                 205             


Gly Ile Leu Ser Ser Val Gly Lys Phe Ser Thr Val Asn Pro Val Tyr 
    210                 215                 220                 


Val Gly Asn Val Ala Trp Ala His Ile Leu Ala Leu Arg Ala Leu Arg 
225                 230                 235                 240 


Asp Pro Lys Lys Ala Pro Ser Val Arg Gly Gln Phe Tyr Tyr Ile Ser 
                245                 250                 255     


Asp Asp Thr Pro His Gln Ser Tyr Asp Asn Leu Asn Tyr Ile Leu Ser 
            260                 265                 270         


Lys Glu Phe Gly Leu Arg Leu Asp Ser Arg Trp Ser Leu Pro Leu Thr 
        275                 280                 285             


Leu Met Tyr Trp Ile Gly Phe Leu Leu Glu Val Val Ser Phe Leu Leu 
    290                 295                 300                 


Ser Pro Ile Tyr Ser Tyr Gln Pro Pro Phe Asn Arg His Thr Val Thr 
305                 310                 315                 320 


Leu Ser Asn Ser Val Phe Thr Phe Ser Tyr Lys Lys Ala Gln Arg Asp 
                325                 330                 335     


Leu Ala Tyr Lys Pro Leu Tyr Ser Trp Glu Glu Ala Lys Gln Lys Thr 
            340                 345                 350         


Val Glu Trp Val Gly Ser Leu Val Asp Arg His Lys Glu Thr Leu Lys 
        355                 360                 365             


Ser Lys Thr Gln 
    370         


<210>  2152
<211>  1976
<212>  PRT
<213>  Homo sapiens

<400>  2152

Met Gly Val Leu Lys Val Trp Leu Gly Leu Ala Leu Ala Leu Ala Glu 
1               5                   10                  15      


Phe Ala Val Leu Pro His His Ser Glu Gly Ala Cys Val Tyr Gln Asp 
            20                  25                  30          


Ser Leu Leu Ala Asp Ala Thr Ile Trp Lys Pro Asp Ser Cys Gln Ser 
        35                  40                  45              


Cys Arg Cys His Gly Asp Ile Val Ile Cys Lys Pro Ala Val Cys Arg 
    50                  55                  60                  


Asn Pro Gln Cys Ala Phe Glu Lys Gly Glu Val Leu Gln Ile Ala Ala 
65                  70                  75                  80  


Asn Gln Cys Cys Pro Glu Cys Val Leu Arg Thr Pro Gly Ser Cys His 
                85                  90                  95      


His Glu Lys Lys Ile His Glu His Gly Thr Glu Trp Ala Ser Ser Pro 
            100                 105                 110         


Cys Ser Val Cys Ser Cys Asn His Gly Glu Val Arg Cys Thr Pro Gln 
        115                 120                 125             


Pro Cys Pro Pro Leu Ser Cys Gly His Gln Glu Leu Ala Phe Ile Pro 
    130                 135                 140                 


Glu Gly Ser Cys Cys Pro Val Cys Val Gly Leu Gly Lys Pro Cys Ser 
145                 150                 155                 160 


Tyr Glu Gly His Val Phe Gln Asp Gly Glu Asp Trp Arg Leu Ser Arg 
                165                 170                 175     


Cys Ala Lys Cys Leu Cys Arg Asn Gly Val Ala Gln Cys Phe Thr Ala 
            180                 185                 190         


Gln Cys Gln Pro Leu Phe Cys Asn Gln Asp Glu Thr Val Val Arg Val 
        195                 200                 205             


Pro Gly Lys Cys Cys Pro Gln Cys Ser Ala Arg Ser Cys Ser Ala Ala 
    210                 215                 220                 


Gly Gln Val Tyr Glu His Gly Glu Gln Trp Ser Glu Asn Ala Cys Thr 
225                 230                 235                 240 


Thr Cys Ile Cys Asp Arg Gly Glu Val Arg Cys His Lys Gln Ala Cys 
                245                 250                 255     


Leu Pro Leu Arg Cys Gly Lys Gly Gln Ser Arg Ala Arg Arg His Gly 
            260                 265                 270         


Gln Cys Cys Glu Glu Cys Val Ser Pro Ala Gly Ser Cys Ser Tyr Asp 
        275                 280                 285             


Gly Val Val Arg Tyr Gln Asp Glu Met Trp Lys Gly Ser Ala Cys Glu 
    290                 295                 300                 


Phe Cys Met Cys Asp His Gly Gln Val Thr Cys Gln Thr Gly Glu Cys 
305                 310                 315                 320 


Ala Lys Val Glu Cys Ala Arg Asp Glu Glu Leu Ile His Leu Asp Gly 
                325                 330                 335     


Lys Cys Cys Pro Glu Cys Ile Ser Arg Asn Gly Tyr Cys Val Tyr Glu 
            340                 345                 350         


Glu Thr Gly Glu Phe Met Ser Ser Asn Ala Ser Glu Val Lys Arg Ile 
        355                 360                 365             


Pro Glu Gly Glu Lys Trp Glu Asp Gly Pro Cys Lys Val Cys Glu Cys 
    370                 375                 380                 


Arg Gly Ala Gln Val Thr Cys Tyr Glu Pro Ser Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Val Gly Thr Leu Ala Leu Glu Val Lys Gly Gln Cys Cys Pro Asp Cys 
                405                 410                 415     


Thr Ser Val His Cys His Pro Asp Cys Leu Thr Cys Ser Gln Ser Pro 
            420                 425                 430         


Asp His Cys Asp Leu Cys Gln Asp Pro Thr Lys Leu Leu Gln Asn Gly 
        435                 440                 445             


Trp Cys Val His Ser Cys Gly Leu Gly Phe Tyr Gln Ala Gly Ser Leu 
    450                 455                 460                 


Cys Leu Ala Cys Gln Pro Gln Cys Ser Thr Cys Thr Ser Gly Leu Glu 
465                 470                 475                 480 


Cys Ser Ser Cys Gln Pro Pro Leu Leu Met Arg His Gly Gln Cys Val 
                485                 490                 495     


Pro Thr Cys Gly Asp Gly Phe Tyr Gln Asp Arg His Ser Cys Ala Val 
            500                 505                 510         


Cys His Glu Ser Cys Ala Gly Cys Trp Gly Pro Thr Glu Lys His Cys 
        515                 520                 525             


Leu Ala Cys Arg Asp Pro Leu His Val Leu Arg Asp Gly Gly Cys Glu 
    530                 535                 540                 


Ser Ser Cys Gly Lys Gly Phe Tyr Asn Arg Gln Gly Thr Cys Ser Ala 
545                 550                 555                 560 


Cys Asp Gln Ser Cys Asp Ser Cys Gly Pro Ser Ser Pro Arg Cys Leu 
                565                 570                 575     


Thr Cys Thr Glu Lys Thr Val Leu His Asp Gly Lys Cys Met Ser Glu 
            580                 585                 590         


Cys Pro Gly Gly Tyr Tyr Ala Asp Ala Thr Gly Arg Cys Lys Val Cys 
        595                 600                 605             


His Asn Ser Cys Ala Ser Cys Ser Gly Pro Thr Pro Ser His Cys Thr 
    610                 615                 620                 


Ala Cys Ser Pro Pro Lys Ala Leu Arg Gln Gly His Cys Leu Pro Arg 
625                 630                 635                 640 


Cys Gly Glu Gly Phe Tyr Ser Asp His Gly Val Cys Lys Ala Cys His 
                645                 650                 655     


Ser Ser Cys Leu Ala Cys Met Gly Pro Ala Pro Ser His Cys Thr Gly 
            660                 665                 670         


Cys Lys Lys Pro Glu Glu Gly Leu Gln Val Glu Gln Leu Ser Asp Val 
        675                 680                 685             


Gly Ile Pro Ser Gly Glu Cys Leu Ala Gln Cys Arg Ala His Phe Tyr 
    690                 695                 700                 


Leu Glu Ser Thr Gly Ile Cys Glu Ala Cys His Gln Ser Cys Phe Arg 
705                 710                 715                 720 


Cys Ala Gly Lys Ser Pro His Asn Cys Thr Asp Cys Gly Pro Ser His 
                725                 730                 735     


Val Leu Leu Asp Gly Gln Cys Leu Ser Gln Cys Pro Asp Gly Tyr Phe 
            740                 745                 750         


His Gln Glu Gly Ser Cys Thr Glu Cys His Pro Thr Cys Arg Gln Cys 
        755                 760                 765             


His Gly Pro Leu Glu Ser Asp Cys Ile Ser Cys Tyr Pro His Ile Ser 
    770                 775                 780                 


Leu Thr Asn Gly Asn Cys Arg Thr Ser Cys Arg Glu Glu Gln Phe Leu 
785                 790                 795                 800 


Asn Leu Val Gly Tyr Cys Ala Asp Cys His His Leu Cys Gln His Cys 
                805                 810                 815     


Ala Ala Asp Leu His Asn Thr Gly Ser Ile Cys Leu Arg Cys Gln Asn 
            820                 825                 830         


Ala His Tyr Leu Leu Leu Gly Asp His Cys Val Pro Asp Cys Pro Ser 
        835                 840                 845             


Gly Tyr Tyr Ala Glu Arg Gly Ala Cys Lys Lys Cys His Ser Ser Cys 
    850                 855                 860                 


Arg Thr Cys Gln Gly Arg Gly Pro Phe Ser Cys Ser Ser Cys Asp Thr 
865                 870                 875                 880 


Asn Leu Val Leu Ser His Thr Gly Thr Cys Ser Thr Thr Cys Phe Pro 
                885                 890                 895     


Gly His Tyr Leu Asp Asp Asn His Val Cys Gln Pro Cys Asn Thr His 
            900                 905                 910         


Cys Gly Ser Cys Asp Ser Gln Ala Ser Cys Thr Ser Cys Arg Asp Pro 
        915                 920                 925             


Asn Lys Val Leu Leu Phe Gly Glu Cys Gln Tyr Glu Ser Cys Ala Pro 
    930                 935                 940                 


Gln Tyr Tyr Leu Asp Phe Ser Thr Asn Thr Cys Lys Glu Cys Asp Trp 
945                 950                 955                 960 


Ser Cys Ser Ala Cys Ser Gly Pro Leu Lys Thr Asp Cys Leu Gln Cys 
                965                 970                 975     


Met Asp Gly Tyr Val Leu Gln Asp Gly Ala Cys Val Glu Gln Cys Leu 
            980                 985                 990         


Ser Ser Phe Tyr Gln Asp Ser Gly  Leu Cys Lys Asn Cys  Asp Ser Tyr 
        995                 1000                 1005             


Cys Leu  Gln Cys Gln Gly Pro  His Glu Cys Thr Arg  Cys Lys Gly 
    1010                 1015                 1020             


Pro Phe  Leu Leu Leu Glu Ala  Gln Cys Val Gln Glu  Cys Gly Lys 
    1025                 1030                 1035             


Gly Tyr  Phe Ala Asp His Ala  Lys His Lys Cys Thr  Ala Cys Pro 
    1040                 1045                 1050             


Gln Gly  Cys Leu Gln Cys Ser  His Arg Asp Arg Cys  His Leu Cys 
    1055                 1060                 1065             


Asp His  Gly Phe Phe Leu Lys  Ser Gly Leu Cys Val  Tyr Asn Cys 
    1070                 1075                 1080             


Val Pro  Gly Phe Ser Val His  Thr Ser Asn Glu Thr  Cys Ser Gly 
    1085                 1090                 1095             


Lys Ile  His Thr Pro Ser Leu  His Val Asn Gly Ser  Leu Ile Leu 
    1100                 1105                 1110             


Pro Ile  Gly Ser Ile Lys Pro  Leu Asp Phe Ser Leu  Leu Asn Val 
    1115                 1120                 1125             


Gln Asp  Gln Glu Gly Arg Val  Glu Asp Leu Leu Phe  His Val Val 
    1130                 1135                 1140             


Ser Thr  Pro Thr Asn Gly Gln  Leu Val Leu Ser Arg  Asn Gly Lys 
    1145                 1150                 1155             


Glu Val  Gln Leu Asp Lys Ala  Gly Arg Phe Ser Trp  Lys Asp Val 
    1160                 1165                 1170             


Asn Glu  Lys Lys Val Arg Phe  Val His Ser Lys Glu  Lys Leu Arg 
    1175                 1180                 1185             


Lys Gly  Tyr Leu Phe Leu Lys  Ile Ser Asp Gln Gln  Phe Phe Ser 
    1190                 1195                 1200             


Glu Pro  Gln Leu Ile Asn Ile  Gln Ala Phe Ser Thr  Gln Ala Pro 
    1205                 1210                 1215             


Tyr Val  Leu Arg Asn Glu Val  Leu His Ile Ser Arg  Gly Glu Arg 
    1220                 1225                 1230             


Ala Thr  Ile Thr Thr Gln Met  Leu Asp Ile Arg Asp  Asp Asp Asn 
    1235                 1240                 1245             


Pro Gln  Asp Val Val Ile Glu  Ile Ile Asp Pro Pro  Leu His Gly 
    1250                 1255                 1260             


Gln Leu  Leu Gln Thr Leu Gln  Ser Pro Ala Thr Pro  Ile Tyr Gln 
    1265                 1270                 1275             


Phe Gln  Leu Asp Glu Leu Ser  Arg Gly Leu Leu His  Tyr Ala His 
    1280                 1285                 1290             


Asp Gly  Ser Asp Ser Thr Ser  Asp Val Ala Val Leu  Gln Ala Asn 
    1295                 1300                 1305             


Asp Gly  His Ser Phe His Asn  Ile Leu Phe Gln Val  Lys Thr Val 
    1310                 1315                 1320             


Pro Gln  Asn Asp Arg Gly Leu  Gln Leu Val Ala Asn  Ser Met Val 
    1325                 1330                 1335             


Trp Val  Pro Glu Gly Gly Met  Leu Gln Ile Thr Asn  Arg Ile Leu 
    1340                 1345                 1350             


Gln Ala  Glu Ala Pro Gly Ala  Ser Ala Glu Glu Ile  Ile Tyr Lys 
    1355                 1360                 1365             


Ile Thr  Gln Asp Tyr Pro Gln  Phe Gly Glu Val Val  Leu Leu Val 
    1370                 1375                 1380             


Asn Met  Pro Ala Asp Ser Pro  Ala Asp Glu Gly Gln  His Leu Pro 
    1385                 1390                 1395             


Asp Gly  Arg Thr Ala Thr Pro  Thr Ser Thr Phe Thr  Gln Gln Asp 
    1400                 1405                 1410             


Ile Asn  Glu Gly Ile Val Trp  Tyr Arg His Ser Gly  Ala Pro Ala 
    1415                 1420                 1425             


Gln Ser  Asp Ser Phe Arg Phe  Glu Val Ser Ser Ala  Ser Asn Ala 
    1430                 1435                 1440             


Gln Thr  Arg Leu Glu Ser His  Met Phe Asn Ile Ala  Ile Leu Pro 
    1445                 1450                 1455             


Gln Thr  Pro Glu Ala Pro Lys  Val Ser Leu Glu Ala  Ser Leu His 
    1460                 1465                 1470             


Met Thr  Ala Arg Glu Asp Gly  Leu Thr Val Ile Gln  Pro His Ser 
    1475                 1480                 1485             


Leu Ser  Phe Ile Asn Ser Glu  Lys Pro Ser Gly Lys  Ile Val Tyr 
    1490                 1495                 1500             


Asn Ile  Thr Leu Pro Leu His  Pro Asn Gln Gly Ile  Ile Glu His 
    1505                 1510                 1515             


Arg Asp  His Pro His Ser Pro  Ile Arg Tyr Phe Thr  Gln Glu Asp 
    1520                 1525                 1530             


Ile Asn  Gln Gly Lys Val Met  Tyr Arg Pro Pro Pro  Ala Ala Pro 
    1535                 1540                 1545             


His Leu  Gln Glu Leu Met Ala  Phe Ser Phe Ala Gly  Leu Pro Glu 
    1550                 1555                 1560             


Ser Val  Lys Phe His Phe Thr  Val Ser Asp Gly Glu  His Thr Ser 
    1565                 1570                 1575             


Pro Glu  Met Val Leu Thr Ile  His Leu Leu Pro Ser  Asp Gln Gln 
    1580                 1585                 1590             


Leu Pro  Val Phe Gln Val Thr  Ala Pro Arg Leu Ala  Val Ser Pro 
    1595                 1600                 1605             


Gly Gly  Ser Thr Ser Val Gly  Leu Gln Val Val Val  Arg Asp Ala 
    1610                 1615                 1620             


Glu Thr  Ala Pro Lys Glu Leu  Phe Phe Glu Leu Arg  Arg Pro Pro 
    1625                 1630                 1635             


Gln His  Gly Val Leu Leu Lys  His Thr Ala Glu Phe  Arg Arg Pro 
    1640                 1645                 1650             


Met Ala  Thr Gly Asp Thr Phe  Thr Tyr Glu Asp Val  Glu Lys Asn 
    1655                 1660                 1665             


Ala Leu  Gln Tyr Ile His Asp  Gly Ser Ser Thr Arg  Glu Asp Ser 
    1670                 1675                 1680             


Met Glu  Ile Ser Val Thr Asp  Gly Leu Thr Val Thr  Met Leu Glu 
    1685                 1690                 1695             


Val Arg  Val Glu Val Ser Leu  Ser Glu Asp Arg Gly  Pro Arg Leu 
    1700                 1705                 1710             


Ala Ala  Gly Ser Ser Leu Ser  Ile Thr Val Ala Ser  Lys Ser Thr 
    1715                 1720                 1725             


Ala Ile  Ile Thr Arg Ser His  Leu Ala Tyr Val Asp  Asp Ser Ser 
    1730                 1735                 1740             


Pro Asp  Pro Glu Ile Trp Ile  Gln Leu Asn Tyr Leu  Pro Ser Tyr 
    1745                 1750                 1755             


Gly Thr  Leu Leu Arg Ile Ser  Gly Ser Glu Val Glu  Glu Leu Ser 
    1760                 1765                 1770             


Glu Val  Ser Asn Phe Thr Met  Glu Asp Ile Asn Asn  Lys Lys Ile 
    1775                 1780                 1785             


Arg Tyr  Ser Ala Val Phe Glu  Thr Asp Gly His Leu  Val Thr Asp 
    1790                 1795                 1800             


Ser Phe  Tyr Phe Ser Val Ser  Asp Met Asp His Asn  His Leu Asp 
    1805                 1810                 1815             


Asn Gln  Ile Phe Thr Ile Met  Ile Thr Pro Ala Glu  Asn Pro Pro 
    1820                 1825                 1830             


Pro Val  Ile Ala Phe Ala Asp  Leu Ile Thr Val Asp  Glu Gly Gly 
    1835                 1840                 1845             


Arg Ala  Pro Leu Ser Phe His  His Phe Phe Ala Thr  Asp Asp Asp 
    1850                 1855                 1860             


Asp Asn  Leu Gln Arg Asp Ala  Ile Ile Lys Leu Ser  Ala Leu Pro 
    1865                 1870                 1875             


Lys Tyr  Gly Cys Ile Glu Asn  Thr Gly Thr Gly Asp  Arg Phe Gly 
    1880                 1885                 1890             


Pro Glu  Thr Ala Ser Asp Leu  Glu Ala Ser Phe Pro  Ile Gln Asp 
    1895                 1900                 1905             


Val Leu  Glu Asn Tyr Ile Tyr  Tyr Phe Gln Ser Val  His Glu Ser 
    1910                 1915                 1920             


Ile Glu  Pro Thr His Asp Ile  Phe Ser Phe Tyr Val  Ser Asp Gly 
    1925                 1930                 1935             


Thr Ser  Arg Ser Glu Ile His  Ser Ile Asn Ile Thr  Ile Glu Val 
    1940                 1945                 1950             


Lys Thr  Leu Glu Val Gly Lys  Val Glu Pro Leu Thr  Thr Ile Phe 
    1955                 1960                 1965             


His Thr  Ile Arg Glu Leu Ser  Leu 
    1970                 1975     


<210>  2153
<211>  1228
<212>  PRT
<213>  Homo sapiens

<400>  2153

Met Ile Trp Pro Lys Val Glu Cys Cys His Phe Lys Thr Ala Val Glu 
1               5                   10                  15      


Ala Pro Leu Gly Met Lys Leu Asp Lys Lys Met Glu Val Phe Ile Pro 
            20                  25                  30          


Leu Ser Thr Ser Ala Ala Ser Ser Gly Pro Trp Ala His Ser Leu Phe 
        35                  40                  45              


Ala Phe Ile Pro Ser Trp Pro Lys Lys Asn Leu Phe Lys Arg Glu Ser 
    50                  55                  60                  


Pro Ile Thr His Arg Leu Tyr Gly Asp Ile Ser Arg Glu Val Gln Gly 
65                  70                  75                  80  


Thr Ser Glu Asn Gly Val Ile Phe Gln Lys Cys Ala Leu Val Ser Gly 
                85                  90                  95      


Ser Ser Glu Ala Gln Thr Ala Arg Ile Trp Leu Leu Val Asn Asn Thr 
            100                 105                 110         


Lys Thr Thr Ser Ser Ala Asn Leu Ser Glu Leu Leu Leu Leu Asp Ser 
        115                 120                 125             


Ile Ala Gly Leu Thr Ile Trp Asp Ser Val Gly Asn Arg Thr Ser Glu 
    130                 135                 140                 


Gly Phe Gln Ala Phe Ser Lys Lys Phe Leu Gln Val Gly Asp Ala Phe 
145                 150                 155                 160 


Ala Val Ser Tyr Ala Ala Thr Leu Gln Ala Gly Asp Leu Gly Asn Gly 
                165                 170                 175     


Glu Ser Leu Lys Leu Pro Ala Gln Leu Thr Phe Gln Ser Ser Ser Arg 
            180                 185                 190         


Asn Arg Thr Gln Leu Lys Val Leu Phe Ser Ile Thr Ala Glu Glu Asn 
        195                 200                 205             


Val Thr Val Leu Pro His His Gly Leu His Ala Ala Gly Phe Phe Ile 
    210                 215                 220                 


Ala Phe Leu Leu Ser Leu Val Leu Thr Trp Ala Ala Leu Phe Leu Met 
225                 230                 235                 240 


Val Arg Tyr Gln Cys Leu Lys Gly Asn Met Leu Thr Arg His Arg Val 
                245                 250                 255     


Trp Gln Tyr Glu Ser Lys Leu Glu Pro Leu Pro Phe Thr Ser Ala Asp 
            260                 265                 270         


Gly Val Asn Glu Asp Leu Ser Leu Asn Asp Gln Met Ile Asp Ile Leu 
        275                 280                 285             


Ser Ser Glu Asp Pro Gly Ser Met Leu Gln Ala Leu Glu Glu Leu Glu 
    290                 295                 300                 


Ile Ala Thr Leu Asn Arg Ala Asp Ala Asp Leu Glu Ala Cys Arg Thr 
305                 310                 315                 320 


Gln Ile Ser Lys Asp Ile Ile Ala Leu Leu Leu Lys Asn Leu Thr Ser 
                325                 330                 335     


Ser Gly His Leu Ser Pro Gln Val Glu Arg Lys Met Ser Ala Val Phe 
            340                 345                 350         


Lys Lys Gln Phe Leu Leu Leu Glu Asn Glu Ile Gln Glu Glu Tyr Asp 
        355                 360                 365             


Arg Lys Met Val Ala Leu Thr Ala Glu Cys Asp Leu Glu Thr Arg Lys 
    370                 375                 380                 


Lys Met Glu Asn Gln Tyr Gln Arg Glu Met Met Ala Met Glu Glu Ala 
385                 390                 395                 400 


Glu Glu Leu Leu Lys Arg Ala Gly Glu Arg Ser Ala Val Glu Cys Ser 
                405                 410                 415     


Asn Leu Leu Arg Thr Leu His Gly Leu Glu Gln Glu His Leu Arg Lys 
            420                 425                 430         


Ser Leu Ala Leu Gln Gln Glu Glu Asp Phe Ala Lys Ala His Arg Gln 
        435                 440                 445             


Leu Ala Val Phe Gln Arg Asn Glu Leu His Ser Ile Phe Phe Thr Gln 
    450                 455                 460                 


Ile Lys Ser Ala Ile Phe Lys Gly Glu Leu Lys Pro Glu Ala Ala Lys 
465                 470                 475                 480 


Met Leu Leu Gln Asn Tyr Ser Lys Ile Gln Glu Asn Val Glu Glu Leu 
                485                 490                 495     


Met Asp Phe Phe Gln Ala Ser Lys Arg Tyr His Leu Ser Lys Arg Phe 
            500                 505                 510         


Gly His Arg Glu Tyr Leu Val Gln Asn Leu Gln Ser Ser Glu Thr Arg 
        515                 520                 525             


Val Gln Gly Leu Leu Ser Thr Ala Ala Ala Gln Leu Thr His Leu Ile 
    530                 535                 540                 


Gln Lys His Glu Arg Ala Gly Tyr Leu Asp Glu Asp Gln Met Glu Met 
545                 550                 555                 560 


Leu Leu Glu Arg Ala Gln Thr Glu Val Phe Ser Ile Lys Gln Lys Leu 
                565                 570                 575     


Asp Asn Asp Leu Lys Gln Glu Lys Lys Lys Leu His Gln Lys Leu Ile 
            580                 585                 590         


Thr Lys Arg Arg Arg Glu Leu Leu Gln Lys His Arg Glu Gln Arg Arg 
        595                 600                 605             


Glu Gln Ala Ser Val Gly Glu Ala Phe Arg Thr Val Glu Asp Ala Gly 
    610                 615                 620                 


Gln Tyr Leu His Gln Lys Arg Ser Leu Met Glu Glu His Gly Ala Thr 
625                 630                 635                 640 


Leu Glu Glu Leu Gln Glu Arg Leu Asp Gln Ala Ala Leu Asp Asp Leu 
                645                 650                 655     


Arg Thr Leu Thr Leu Ser Leu Phe Glu Lys Ala Thr Asp Glu Leu Arg 
            660                 665                 670         


Arg Leu Gln Asn Ser Ala Met Thr Gln Glu Leu Leu Lys Arg Gly Val 
        675                 680                 685             


Pro Trp Leu Phe Leu Gln Gln Ile Leu Glu Glu His Gly Lys Glu Met 
    690                 695                 700                 


Ala Ala Arg Ala Glu Gln Leu Glu Gly Glu Glu Arg Asp Arg Asp Gln 
705                 710                 715                 720 


Glu Gly Val Gln Ser Val Arg Gln Arg Leu Lys Asp Asp Ala Pro Glu 
                725                 730                 735     


Ala Val Thr Glu Glu Gln Ala Glu Leu Arg Arg Trp Glu His Leu Ile 
            740                 745                 750         


Phe Met Lys Leu Cys Ser Ser Val Phe Ser Leu Ser Glu Glu Glu Leu 
        755                 760                 765             


Leu Arg Met Arg Gln Glu Val His Gly Cys Phe Ala Gln Met Asp Arg 
    770                 775                 780                 


Ser Leu Ala Leu Pro Lys Ile Arg Ala Arg Val Leu Leu Gln Gln Phe 
785                 790                 795                 800 


Gln Thr Ala Trp Arg Glu Ala Glu Phe Val Lys Leu Asp Gln Ala Val 
                805                 810                 815     


Ala Ala Pro Glu Leu Gln Gln Gln Ser Lys Val Arg Lys Ser Arg Ser 
            820                 825                 830         


Lys Ser Lys Ser Lys Gly Glu Leu Leu Lys Lys Cys Ile Glu Asp Lys 
        835                 840                 845             


Ile His Leu Cys Glu Glu Gln Ala Ser Glu Asp Leu Val Glu Lys Val 
    850                 855                 860                 


Arg Gly Glu Leu Leu Arg Glu Arg Val Gln Arg Met Glu Ala Gln Glu 
865                 870                 875                 880 


Gly Gly Phe Ala Gln Ser Leu Val Ala Leu Gln Phe Gln Lys Ala Ser 
                885                 890                 895     


Arg Val Thr Glu Thr Leu Ser Ala Tyr Thr Ala Leu Leu Ser Ile Gln 
            900                 905                 910         


Asp Leu Leu Leu Glu Glu Leu Ser Ala Ser Glu Met Leu Thr Lys Ser 
        915                 920                 925             


Ala Cys Thr Gln Ile Leu Glu Ser His Ser Arg Glu Leu Gln Glu Leu 
    930                 935                 940                 


Glu Arg Lys Leu Glu Asp Gln Leu Val Gln Gln Glu Ala Ala Gln Gln 
945                 950                 955                 960 


Gln Gln Ala Leu Ala Ser Trp Gln Gln Trp Val Ala Asp Gly Pro Gly 
                965                 970                 975     


Ile Leu Asn Glu Pro Gly Glu Val Asp Ser Glu Arg Gln Val Ser Thr 
            980                 985                 990         


Val Leu His Gln Ala Leu Ser Lys  Ser Gln Thr Leu Leu  Glu Gln His 
        995                 1000                 1005             


Gln Gln  Cys Leu Arg Glu Glu  Gln Gln Asn Ser Val  Val Leu Glu 
    1010                 1015                 1020             


Asp Leu  Leu Glu Asn Met Glu  Ala Asp Thr Phe Ala  Thr Leu Cys 
    1025                 1030                 1035             


Ser Gln  Glu Leu Arg Leu Ala  Ser Tyr Leu Ala Arg  Met Ala Met 
    1040                 1045                 1050             


Val Pro  Gly Ala Thr Leu Arg  Arg Leu Leu Ser Val  Val Leu Pro 
    1055                 1060                 1065             


Thr Ala  Ser Gln Pro Gln Leu  Leu Ala Leu Leu Asp  Ser Ala Thr 
    1070                 1075                 1080             


Glu Arg  His Val Asp His Ala  Ala Glu Ser Asp Gly  Gly Ala Glu 
    1085                 1090                 1095             


Gln Ala  Asp Val Gly Arg Arg  Arg Lys His Gln Ser  Trp Trp Gln 
    1100                 1105                 1110             


Ala Leu  Asp Gly Lys Leu Arg  Gly Asp Leu Ile Ser  Arg Gly Leu 
    1115                 1120                 1125             


Glu Lys  Met Leu Trp Ala Arg  Lys Arg Lys Gln Ser  Ile Leu Lys 
    1130                 1135                 1140             


Lys Thr  Cys Leu Pro Leu Arg  Glu Arg Met Ile Phe  Ser Gly Lys 
    1145                 1150                 1155             


Gly Ser  Trp Pro His Leu Ser  Leu Glu Pro Ile Gly  Glu Leu Ala 
    1160                 1165                 1170             


Pro Val  Pro Ile Val Gly Ala  Glu Thr Ile Asp Leu  Leu Asn Thr 
    1175                 1180                 1185             


Gly Glu  Lys Leu Phe Ile Phe  Arg Asn Pro Lys Glu  Pro Glu Ile 
    1190                 1195                 1200             


Ser Leu  His Val Pro Pro Arg  Lys Lys Lys Asn Phe  Leu Asn Ala 
    1205                 1210                 1215             


Lys Lys  Ala Met Arg Ala Leu  Gly Met Asp 
    1220                 1225             


<210>  2154
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  2154

Met Glu Ser Gly Leu Leu Arg Pro Ala Pro Val Ser Glu Val Ile Val 
1               5                   10                  15      


Leu His Tyr Asn Tyr Thr Gly Lys Leu Arg Gly Ala Arg Tyr Gln Pro 
            20                  25                  30          


Gly Ala Gly Leu Arg Ala Asp Ala Val Val Cys Leu Ala Val Cys Ala 
        35                  40                  45              


Phe Ile Val Leu Glu Asn Leu Ala Val Leu Leu Val Leu Gly Arg His 
    50                  55                  60                  


Pro Arg Phe His Ala Pro Met Phe Leu Leu Leu Gly Ser Leu Thr Leu 
65                  70                  75                  80  


Ser Asp Leu Leu Ala Gly Ala Ala Tyr Ala Ala Asn Ile Leu Leu Ser 
                85                  90                  95      


Gly Pro Leu Thr Leu Lys Leu Ser Pro Ala Leu Trp Phe Ala Arg Glu 
            100                 105                 110         


Gly Gly Val Phe Val Ala Leu Thr Ala Ser Val Leu Ser Leu Leu Ala 
        115                 120                 125             


Ile Ala Leu Glu Arg Ser Leu Thr Met Ala Arg Arg Gly Pro Ala Pro 
    130                 135                 140                 


Val Ser Ser Arg Gly Arg Thr Leu Ala Met Ala Ala Ala Ala Trp Gly 
145                 150                 155                 160 


Val Ser Leu Leu Leu Gly Leu Leu Pro Ala Leu Gly Trp Asn Cys Leu 
                165                 170                 175     


Gly Arg Leu Asp Ala Cys Ser Thr Val Leu Pro Leu Tyr Ala Lys Ala 
            180                 185                 190         


Tyr Val Leu Phe Cys Val Leu Ala Phe Val Gly Ile Leu Ala Ala Ile 
        195                 200                 205             


Cys Ala Leu Tyr Ala Arg Ile Tyr Cys Gln Val Arg Ala Asn Ala Arg 
    210                 215                 220                 


Arg Leu Pro Ala Arg Pro Gly Thr Ala Gly Thr Thr Ser Thr Arg Ala 
225                 230                 235                 240 


Arg Arg Lys Pro Arg Ser Leu Ala Leu Leu Arg Thr Leu Ser Val Val 
                245                 250                 255     


Leu Leu Ala Phe Val Ala Cys Trp Gly Pro Leu Phe Leu Leu Leu Leu 
            260                 265                 270         


Leu Asp Val Ala Cys Pro Ala Arg Thr Cys Pro Val Leu Leu Gln Ala 
        275                 280                 285             


Asp Pro Phe Leu Gly Leu Ala Met Ala Asn Ser Leu Leu Asn Pro Ile 
    290                 295                 300                 


Ile Tyr Thr Leu Thr Asn Arg Asp Leu Arg His Ala Leu Leu Arg Leu 
305                 310                 315                 320 


Val Cys Cys Gly Arg His Ser Cys Gly Arg Asp Pro Ser Gly Ser Gln 
                325                 330                 335     


Gln Ser Ala Ser Ala Ala Glu Ala Ser Gly Gly Leu Arg Arg Cys Leu 
            340                 345                 350         


Pro Pro Gly Leu Asp Gly Ser Phe Ser Gly Ser Glu Arg Ser Ser Pro 
        355                 360                 365             


Gln Arg Asp Gly Leu Asp Thr Ser Gly Ser Thr Gly Ser Pro Gly Ala 
    370                 375                 380                 


Pro Thr Ala Ala Arg Thr Leu Val Ser Glu Pro Ala Ala Asp 
385                 390                 395             


<210>  2155
<211>  892
<212>  PRT
<213>  Homo sapiens

<400>  2155

Met Lys Ile Ile Phe Pro Ile Leu Ser Asn Pro Val Phe Arg Arg Thr 
1               5                   10                  15      


Val Lys Leu Leu Leu Cys Leu Leu Trp Ile Gly Tyr Ser Gln Gly Thr 
            20                  25                  30          


Thr His Val Leu Arg Phe Gly Gly Ile Phe Glu Tyr Val Glu Ser Gly 
        35                  40                  45              


Pro Met Gly Ala Glu Glu Leu Ala Phe Arg Phe Ala Val Asn Thr Ile 
    50                  55                  60                  


Asn Arg Asn Arg Thr Leu Leu Pro Asn Thr Thr Leu Thr Tyr Asp Thr 
65                  70                  75                  80  


Gln Lys Ile Asn Leu Tyr Asp Ser Phe Glu Ala Ser Lys Lys Ala Cys 
                85                  90                  95      


Asp Gln Leu Ser Leu Gly Val Ala Ala Ile Phe Gly Pro Ser His Ser 
            100                 105                 110         


Ser Ser Ala Asn Ala Val Gln Ser Ile Cys Asn Ala Leu Gly Val Pro 
        115                 120                 125             


His Ile Gln Thr Arg Trp Lys His Gln Val Ser Asp Asn Lys Asp Ser 
    130                 135                 140                 


Phe Tyr Val Ser Leu Tyr Pro Asp Phe Ser Ser Leu Ser Arg Ala Ile 
145                 150                 155                 160 


Leu Asp Leu Val Gln Phe Phe Lys Trp Lys Thr Val Thr Val Val Tyr 
                165                 170                 175     


Asp Asp Ser Thr Gly Leu Ile Arg Leu Gln Glu Leu Ile Lys Ala Pro 
            180                 185                 190         


Ser Arg Tyr Asn Leu Arg Leu Lys Ile Arg Gln Leu Pro Ala Asp Thr 
        195                 200                 205             


Lys Asp Ala Lys Pro Leu Leu Lys Glu Met Lys Arg Gly Lys Glu Phe 
    210                 215                 220                 


His Val Ile Phe Asp Cys Ser His Glu Met Ala Ala Gly Ile Leu Lys 
225                 230                 235                 240 


Gln Ala Leu Ala Met Gly Met Met Thr Glu Tyr Tyr His Tyr Ile Phe 
                245                 250                 255     


Thr Thr Leu Asp Leu Phe Ala Leu Asp Val Glu Pro Tyr Arg Tyr Ser 
            260                 265                 270         


Gly Val Asn Met Thr Gly Phe Arg Ile Leu Asn Thr Glu Asn Thr Gln 
        275                 280                 285             


Val Ser Ser Ile Ile Glu Lys Trp Ser Met Glu Arg Leu Gln Ala Pro 
    290                 295                 300                 


Pro Lys Pro Asp Ser Gly Leu Leu Asp Gly Phe Met Thr Thr Asp Ala 
305                 310                 315                 320 


Ala Leu Met Tyr Asp Ala Val His Val Val Ser Val Ala Val Gln Gln 
                325                 330                 335     


Phe Pro Gln Met Thr Val Ser Ser Leu Gln Cys Asn Arg His Lys Pro 
            340                 345                 350         


Trp Arg Phe Gly Thr Arg Phe Met Ser Leu Ile Lys Glu Ala His Trp 
        355                 360                 365             


Glu Gly Leu Thr Gly Arg Ile Thr Phe Asn Lys Thr Asn Gly Leu Arg 
    370                 375                 380                 


Thr Asp Phe Asp Leu Asp Val Ile Ser Leu Lys Glu Glu Gly Leu Glu 
385                 390                 395                 400 


Lys Ile Gly Thr Trp Asp Pro Ala Ser Gly Leu Asn Met Thr Glu Ser 
                405                 410                 415     


Gln Lys Gly Lys Pro Ala Asn Ile Thr Asp Ser Leu Ser Asn Arg Ser 
            420                 425                 430         


Leu Ile Val Thr Thr Ile Leu Glu Glu Pro Tyr Val Leu Phe Lys Lys 
        435                 440                 445             


Ser Asp Lys Pro Leu Tyr Gly Asn Asp Arg Phe Glu Gly Tyr Cys Ile 
    450                 455                 460                 


Asp Leu Leu Arg Glu Leu Ser Thr Ile Leu Gly Phe Thr Tyr Glu Ile 
465                 470                 475                 480 


Arg Leu Val Glu Asp Gly Lys Tyr Gly Ala Gln Asp Asp Ala Asn Gly 
                485                 490                 495     


Gln Trp Asn Gly Met Val Arg Glu Leu Ile Asp His Lys Ala Asp Leu 
            500                 505                 510         


Ala Val Ala Pro Leu Ala Ile Thr Tyr Val Arg Glu Lys Val Ile Asp 
        515                 520                 525             


Phe Ser Lys Pro Phe Met Thr Leu Gly Ile Ser Ile Leu Tyr Arg Lys 
    530                 535                 540                 


Pro Asn Gly Thr Asn Pro Gly Val Phe Ser Phe Leu Asn Pro Leu Ser 
545                 550                 555                 560 


Pro Asp Ile Trp Met Tyr Ile Leu Leu Ala Tyr Leu Gly Val Ser Cys 
                565                 570                 575     


Val Leu Phe Val Ile Ala Arg Phe Ser Pro Tyr Glu Trp Tyr Asn Pro 
            580                 585                 590         


His Pro Cys Asn Pro Asp Ser Asp Val Val Glu Asn Asn Phe Thr Leu 
        595                 600                 605             


Leu Asn Ser Phe Trp Phe Gly Val Gly Ala Leu Met Gln Gln Gly Ser 
    610                 615                 620                 


Glu Leu Met Pro Lys Ala Leu Ser Thr Arg Ile Val Gly Gly Ile Trp 
625                 630                 635                 640 


Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala 
                645                 650                 655     


Ala Phe Leu Thr Val Glu Arg Met Glu Ser Pro Ile Asp Ser Ala Asp 
            660                 665                 670         


Asp Leu Ala Lys Gln Thr Lys Ile Glu Tyr Gly Ala Val Glu Asp Gly 
        675                 680                 685             


Ala Thr Met Thr Phe Phe Lys Lys Ser Lys Ile Ser Thr Tyr Asp Lys 
    690                 695                 700                 


Met Trp Ala Phe Met Ser Ser Arg Arg Gln Ser Val Leu Val Lys Ser 
705                 710                 715                 720 


Asn Glu Glu Gly Ile Gln Arg Val Leu Thr Ser Asp Tyr Ala Phe Leu 
                725                 730                 735     


Met Glu Ser Thr Thr Ile Glu Phe Val Thr Gln Arg Asn Cys Asn Leu 
            740                 745                 750         


Thr Gln Ile Gly Gly Leu Ile Asp Ser Lys Gly Tyr Gly Val Gly Thr 
        755                 760                 765             


Pro Met Gly Ser Pro Tyr Arg Asp Lys Ile Thr Ile Ala Ile Leu Gln 
    770                 775                 780                 


Leu Gln Glu Glu Gly Lys Leu His Met Met Lys Glu Lys Trp Trp Arg 
785                 790                 795                 800 


Gly Asn Gly Cys Pro Glu Glu Glu Ser Lys Glu Ala Ser Ala Leu Gly 
                805                 810                 815     


Val Gln Asn Ile Gly Gly Ile Phe Ile Val Leu Ala Ala Gly Leu Val 
            820                 825                 830         


Leu Ser Val Phe Val Ala Val Gly Glu Phe Leu Tyr Lys Ser Lys Lys 
        835                 840                 845             


Asn Ala Gln Leu Glu Lys Arg Ala Lys Thr Lys Leu Pro Gln Asp Tyr 
    850                 855                 860                 


Val Phe Leu Pro Ile Leu Glu Ser Val Ser Ile Ser Thr Val Leu Ser 
865                 870                 875                 880 


Ser Ser Pro Ser Ser Ser Ser Leu Ser Ser Cys Ser 
                885                 890         


<210>  2156
<211>  705
<212>  PRT
<213>  Homo sapiens

<400>  2156

Met Gln Arg Ala Gly Ser Ser Gly Gly Arg Gly Glu Cys Asp Ile Ser 
1               5                   10                  15      


Gly Ala Gly Arg Leu Gly Leu Glu Glu Ala Ala Arg Leu Ser Cys Ala 
            20                  25                  30          


Val His Thr Ser Pro Gly Gly Gly Arg Arg Pro Gly Gln Ala Ala Gly 
        35                  40                  45              


Met Ser Ala Lys Glu Arg Pro Lys Gly Lys Val Ile Lys Asp Ser Val 
    50                  55                  60                  


Thr Leu Leu Pro Cys Phe Tyr Phe Val Glu Leu Pro Ile Leu Ala Ser 
65                  70                  75                  80  


Ser Val Val Ser Leu Tyr Phe Leu Glu Leu Thr Asp Val Phe Lys Pro 
                85                  90                  95      


Val His Ser Gly Phe Ser Cys Tyr Asp Arg Ser Leu Ser Met Pro Tyr 
            100                 105                 110         


Ile Glu Pro Thr Gln Glu Ala Ile Pro Phe Leu Met Leu Leu Ser Leu 
        115                 120                 125             


Ala Phe Ala Gly Pro Ala Ile Thr Ile Met Val Gly Glu Gly Ile Leu 
    130                 135                 140                 


Tyr Cys Cys Leu Ser Lys Arg Arg Asn Gly Val Gly Leu Glu Pro Asn 
145                 150                 155                 160 


Ile Asn Ala Gly Gly Cys Asn Phe Asn Ser Phe Leu Arg Arg Ala Val 
                165                 170                 175     


Arg Phe Val Gly Val His Val Phe Gly Leu Cys Ser Thr Ala Leu Ile 
            180                 185                 190         


Thr Asp Ile Ile Gln Leu Ser Thr Gly Tyr Gln Ala Pro Tyr Phe Leu 
        195                 200                 205             


Thr Val Cys Lys Pro Asn Tyr Thr Ser Leu Asn Val Ser Cys Lys Glu 
    210                 215                 220                 


Asn Ser Tyr Ile Val Glu Asp Ile Cys Ser Gly Ser Asp Leu Thr Val 
225                 230                 235                 240 


Ile Asn Ser Gly Arg Lys Ser Phe Pro Ser Gln His Ala Thr Leu Ala 
                245                 250                 255     


Ala Phe Ala Ala Val Tyr Val Ser Gly Leu Tyr Ala Val Gly Asn Phe 
            260                 265                 270         


Leu Pro Ser Asp Glu Ser Met Phe Gln His Arg Asp Ala Leu Arg Ser 
        275                 280                 285             


Leu Thr Asp Leu Asn Gln Asp Pro Asn Arg Leu Leu Ser Ala Lys Asn 
    290                 295                 300                 


Gly Ser Ser Ser Asp Gly Ile Ala His Thr Glu Gly Ile Leu Asn Arg 
305                 310                 315                 320 


Asn His Arg Asp Ala Ser Ser Leu Thr Asn Leu Lys Arg Ala Asn Ala 
                325                 330                 335     


Asp Val Glu Ile Ile Thr Pro Arg Ser Pro Met Gly Lys Glu Asn Met 
            340                 345                 350         


Val Thr Phe Ser Asn Thr Leu Pro Arg Ala Asn Thr Pro Ser Val Glu 
        355                 360                 365             


Asp Pro Val Arg Arg Asn Ala Ser Ile His Ala Ser Met Asp Ser Ala 
    370                 375                 380                 


Arg Ser Lys Gln Leu Leu Thr Gln Trp Lys Asn Lys Asn Glu Ser Arg 
385                 390                 395                 400 


Lys Leu Ser Leu Gln Val Ile Glu Pro Glu Pro Gly Gln Ser Pro Pro 
                405                 410                 415     


Arg Ser Ile Glu Met Arg Ser Ser Ser Glu Pro Ser Arg Val Gly Val 
            420                 425                 430         


Asn Gly Asp His His Gly Pro Gly Asn Gln Tyr Leu Lys Ile Gln Pro 
        435                 440                 445             


Gly Ala Val Pro Gly Cys Asn Asn Ser Met Pro Gly Gly Pro Arg Val 
    450                 455                 460                 


Ser Ile Gln Ser Arg Pro Gly Ser Ser Gln Leu Val His Ile Pro Glu 
465                 470                 475                 480 


Glu Thr Gln Glu Asn Ile Ser Thr Ser Pro Lys Ser Ser Ser Ala Arg 
                485                 490                 495     


Ala Lys Trp Leu Lys Ala Ala Glu Lys Thr Val Ala Cys Asn Arg Ser 
            500                 505                 510         


Asn Ser Gln Pro Arg Ile Met Gln Val Ile Ala Met Ser Lys Gln Gln 
        515                 520                 525             


Gly Val Leu Gln Ser Ser Pro Lys Asn Thr Glu Gly Ser Thr Val Ser 
    530                 535                 540                 


Cys Thr Gly Ser Ile Arg Tyr Lys Thr Leu Thr Asp His Glu Pro Ser 
545                 550                 555                 560 


Gly Ile Val Arg Val Glu Ala His Pro Glu Asn Asn Arg Pro Ile Ile 
                565                 570                 575     


Gln Ile Pro Ser Thr Glu Gly Glu Gly Ser Gly Ser Trp Lys Trp Lys 
            580                 585                 590         


Ala Pro Glu Lys Gly Ser Leu Arg Gln Thr Tyr Glu Leu Asn Asp Leu 
        595                 600                 605             


Asn Arg Asp Ser Glu Ser Cys Glu Ser Leu Lys Asp Ser Phe Gly Ser 
    610                 615                 620                 


Gly Asp Arg Lys Arg Ser Asn Ile Asp Ser Asn Glu His His His His 
625                 630                 635                 640 


Gly Ile Thr Thr Ile Arg Val Thr Pro Val Glu Gly Ser Glu Ile Gly 
                645                 650                 655     


Ser Glu Thr Leu Ser Ile Ser Ser Ser Arg Asp Ser Thr Leu Arg Arg 
            660                 665                 670         


Lys Gly Asn Ile Ile Leu Ile Pro Glu Arg Ser Asn Ser Pro Glu Asn 
        675                 680                 685             


Thr Arg Asn Ile Phe Tyr Lys Gly Thr Ser Pro Thr Arg Ala Tyr Lys 
    690                 695                 700                 


Asp 
705 


<210>  2157
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  2157

Met Ala Trp Trp Leu Ile Ala Phe Ala His Gly Asp Leu Ala Pro Ser 
1               5                   10                  15      


Glu Gly Thr Ala Glu Pro Cys Val Thr Ser Ile His Ser Phe Ser Ser 
            20                  25                  30          


Ala Phe Leu Phe Ser Ile Glu Val Gln Val Thr Ile Gly Phe Gly Gly 
        35                  40                  45              


Arg Met Val Thr Glu Glu Cys Pro Leu Ala Ile Leu Ile Leu Ile Val 
    50                  55                  60                  


Gln Asn Ile Val Gly Leu Met Ile Asn Ala Ile Met Leu Gly Cys Ile 
65                  70                  75                  80  


Phe Met Lys Thr Ala Gln Ala His Arg Arg Ala Glu Thr Leu Ile Phe 
                85                  90                  95      


Ser Lys His Ala Val Ile Ala Leu Arg His Gly Arg Leu Cys Phe Met 
            100                 105                 110         


Leu Arg Val Gly Asp Leu Arg Lys Ser Met Ile Ile Ser Ala Thr Ile 
        115                 120                 125             


His Met Gln Val Val Arg Lys Thr Thr Ser Pro Glu Gly Glu Val Val 
    130                 135                 140                 


Pro Leu His Gln Val Asp Ile Pro Met Glu Asn Gly Val Gly Gly Asn 
145                 150                 155                 160 


Ser Ile Phe Leu Val Ala Pro Leu Ile Ile Tyr His Val Ile Asp Ala 
                165                 170                 175     


Asn Ser Pro Leu Tyr Asp Leu Ala Pro Ser Asp Leu His His His Gln 
            180                 185                 190         


Asp Leu Glu Ile Ile Val Ile Leu Glu Gly Val Val Glu Thr Thr Gly 
        195                 200                 205             


Ile Thr Thr Gln Ala Arg Thr Ser Tyr Leu Ala Asp Glu Ile Leu Trp 
    210                 215                 220                 


Gly Gln Arg Phe Val Pro Ile Val Ala Glu Glu Asp Gly Arg Tyr Ser 
225                 230                 235                 240 


Val Asp Tyr Ser Lys Phe Gly Asn Thr Val Lys Val Pro Thr Pro Leu 
                245                 250                 255     


Cys Thr Ala Arg Gln Leu Asp Glu Asp His Ser Leu Leu Glu Ala Leu 
            260                 265                 270         


Thr Leu Ala Ser Ala Arg Gly Pro Leu Arg Lys Arg Ser Val Pro Met 
        275                 280                 285             


Ala Lys Ala Lys Pro Lys Phe Ser Ile Ser Pro Asp Ser Leu Ser 
    290                 295                 300             


<210>  2158
<211>  1146
<212>  PRT
<213>  Homo sapiens

<400>  2158

Met Thr Arg Ser Pro Pro Leu Arg Glu Leu Pro Pro Ser Tyr Thr Pro 
1               5                   10                  15      


Pro Ala Arg Thr Ala Ala Pro Gln Ile Leu Ala Gly Ser Leu Lys Ala 
            20                  25                  30          


Pro Leu Trp Leu Arg Ala Tyr Phe Gln Gly Leu Leu Phe Ser Leu Gly 
        35                  40                  45              


Cys Gly Ile Gln Arg His Cys Gly Lys Val Leu Phe Leu Gly Leu Leu 
    50                  55                  60                  


Ala Phe Gly Ala Leu Ala Leu Gly Leu Arg Met Ala Ile Ile Glu Thr 
65                  70                  75                  80  


Asn Leu Glu Gln Leu Trp Val Glu Val Gly Ser Arg Val Ser Gln Glu 
                85                  90                  95      


Leu His Tyr Thr Lys Glu Lys Leu Gly Glu Glu Ala Ala Tyr Thr Ser 
            100                 105                 110         


Gln Met Leu Ile Gln Thr Ala Arg Gln Glu Gly Glu Asn Ile Leu Thr 
        115                 120                 125             


Pro Glu Ala Leu Gly Leu His Leu Gln Ala Ala Leu Thr Ala Ser Lys 
    130                 135                 140                 


Val Gln Val Ser Leu Tyr Gly Lys Ser Trp Asp Leu Asn Lys Ile Cys 
145                 150                 155                 160 


Tyr Lys Ser Gly Val Pro Leu Ile Glu Asn Gly Met Ile Glu Arg Met 
                165                 170                 175     


Ile Glu Lys Leu Phe Pro Cys Val Ile Leu Thr Pro Leu Asp Cys Phe 
            180                 185                 190         


Trp Glu Gly Ala Lys Leu Gln Gly Gly Ser Ala Tyr Leu Pro Gly Arg 
        195                 200                 205             


Pro Asp Ile Gln Trp Thr Asn Leu Asp Pro Glu Gln Leu Leu Glu Glu 
    210                 215                 220                 


Leu Gly Pro Phe Ala Ser Leu Glu Gly Phe Arg Glu Leu Leu Asp Lys 
225                 230                 235                 240 


Ala Gln Val Gly Gln Ala Tyr Val Gly Arg Pro Cys Leu His Pro Asp 
                245                 250                 255     


Asp Leu His Cys Pro Pro Ser Ala Pro Asn His His Ser Arg Gln Ala 
            260                 265                 270         


Pro Asn Val Ala His Glu Leu Ser Gly Gly Cys His Gly Phe Ser His 
        275                 280                 285             


Lys Phe Met His Trp Gln Glu Glu Leu Leu Leu Gly Gly Met Ala Arg 
    290                 295                 300                 


Asp Pro Gln Gly Glu Leu Leu Arg Ala Glu Ala Leu Gln Ser Thr Phe 
305                 310                 315                 320 


Leu Leu Met Ser Pro Arg Gln Leu Tyr Glu His Phe Arg Gly Asp Tyr 
                325                 330                 335     


Gln Thr His Asp Ile Gly Trp Ser Glu Glu Gln Ala Ser Thr Val Leu 
            340                 345                 350         


Gln Ala Trp Gln Arg Arg Phe Val Gln Leu Ala Gln Glu Ala Leu Pro 
        355                 360                 365             


Glu Asn Ala Ser Gln Gln Ile His Ala Phe Ser Ser Thr Thr Leu Asp 
    370                 375                 380                 


Asp Ile Leu His Ala Phe Ser Glu Val Ser Ala Ala Arg Val Val Gly 
385                 390                 395                 400 


Gly Tyr Leu Leu Met Leu Ala Tyr Ala Cys Val Thr Met Leu Arg Trp 
                405                 410                 415     


Asp Cys Ala Gln Ser Gln Gly Ser Val Gly Leu Ala Gly Val Leu Leu 
            420                 425                 430         


Val Ala Leu Ala Val Ala Ser Gly Leu Gly Leu Cys Ala Leu Leu Gly 
        435                 440                 445             


Ile Thr Phe Asn Ala Ala Thr Thr Gln Val Leu Pro Phe Leu Ala Leu 
    450                 455                 460                 


Gly Ile Gly Val Asp Asp Val Phe Leu Leu Ala His Ala Phe Thr Glu 
465                 470                 475                 480 


Ala Leu Pro Gly Thr Pro Leu Gln Glu Arg Met Gly Glu Cys Leu Gln 
                485                 490                 495     


Arg Thr Gly Thr Ser Val Val Leu Thr Ser Ile Asn Asn Met Ala Ala 
            500                 505                 510         


Phe Leu Met Ala Ala Leu Val Pro Ile Pro Ala Leu Arg Ala Phe Ser 
        515                 520                 525             


Leu Gln Ala Ala Ile Val Val Gly Cys Thr Phe Val Ala Val Met Leu 
    530                 535                 540                 


Val Phe Pro Ala Ile Leu Ser Leu Asp Leu Arg Arg Arg His Cys Gln 
545                 550                 555                 560 


Arg Leu Asp Val Leu Cys Cys Phe Ser Ser Pro Cys Ser Ala Gln Val 
                565                 570                 575     


Ile Gln Ile Leu Pro Gln Glu Leu Gly Asp Gly Thr Val Pro Val Gly 
            580                 585                 590         


Ile Ala His Leu Thr Ala Thr Val Gln Ala Phe Thr His Cys Glu Ala 
        595                 600                 605             


Ser Ser Gln His Val Val Thr Ile Leu Pro Pro Gln Ala His Leu Val 
    610                 615                 620                 


Pro Pro Pro Ser Asp Pro Leu Gly Ser Glu Leu Phe Ser Pro Gly Gly 
625                 630                 635                 640 


Ser Thr Arg Asp Leu Leu Gly Gln Glu Glu Glu Thr Arg Gln Lys Ala 
                645                 650                 655     


Ala Cys Lys Ser Leu Pro Cys Ala Arg Trp Asn Leu Ala His Phe Ala 
            660                 665                 670         


Arg Tyr Gln Phe Ala Pro Leu Leu Leu Gln Ser His Ala Lys Ala Ile 
        675                 680                 685             


Val Leu Val Leu Phe Gly Ala Leu Leu Gly Leu Ser Leu Tyr Gly Ala 
    690                 695                 700                 


Thr Leu Val Gln Asp Gly Leu Ala Leu Thr Asp Val Val Pro Arg Gly 
705                 710                 715                 720 


Thr Lys Glu His Ala Phe Leu Ser Ala Gln Leu Arg Tyr Phe Ser Leu 
                725                 730                 735     


Tyr Glu Val Ala Leu Val Thr Gln Gly Gly Phe Asp Tyr Ala His Ser 
            740                 745                 750         


Gln Arg Ala Leu Phe Asp Leu His Gln Arg Phe Ser Ser Leu Lys Ala 
        755                 760                 765             


Val Leu Pro Pro Pro Ala Thr Gln Ala Pro Arg Thr Trp Leu His Tyr 
    770                 775                 780                 


Tyr Arg Asn Trp Leu Gln Gly Ile Gln Ala Ala Phe Asp Gln Asp Trp 
785                 790                 795                 800 


Ala Ser Gly Arg Ile Thr Arg His Ser Tyr Arg Asn Gly Ser Glu Asp 
                805                 810                 815     


Gly Ala Leu Ala Tyr Lys Leu Leu Ile Gln Thr Gly Asp Ala Gln Glu 
            820                 825                 830         


Pro Leu Asp Phe Ser Gln Leu Thr Thr Arg Lys Leu Val Asp Arg Glu 
        835                 840                 845             


Gly Leu Ile Pro Pro Glu Leu Phe Tyr Met Gly Leu Thr Val Trp Val 
    850                 855                 860                 


Ser Ser Asp Pro Leu Gly Leu Ala Ala Ser Gln Ala Asn Phe Tyr Pro 
865                 870                 875                 880 


Pro Pro Pro Glu Trp Leu His Asp Lys Tyr Asp Thr Thr Gly Glu Asn 
                885                 890                 895     


Leu Arg Ile Pro Pro Ala Gln Pro Leu Glu Phe Ala Gln Phe Pro Phe 
            900                 905                 910         


Leu Leu Arg Gly Leu Gln Lys Thr Ala Asp Phe Val Glu Ala Ile Glu 
        915                 920                 925             


Gly Ala Arg Ala Ala Cys Ala Glu Ala Gly Gln Ala Gly Val His Ala 
    930                 935                 940                 


Tyr Pro Ser Gly Ser Pro Phe Leu Phe Trp Glu Gln Tyr Leu Gly Leu 
945                 950                 955                 960 


Arg Arg Cys Phe Leu Leu Ala Val Cys Ile Leu Leu Val Cys Thr Phe 
                965                 970                 975     


Leu Val Cys Ala Leu Leu Leu Leu Asn Pro Trp Thr Ala Gly Leu Ile 
            980                 985                 990         


Val Leu Val Leu Ala Met Met Thr  Val Glu Leu Phe Gly  Ile Met Gly 
        995                 1000                 1005             


Phe Leu  Gly Ile Lys Leu Ser  Ala Ile Pro Val Val  Ile Leu Val 
    1010                 1015                 1020             


Ala Ser  Val Gly Ile Gly Val  Glu Phe Thr Val His  Val Ala Leu 
    1025                 1030                 1035             


Gly Phe  Leu Thr Thr Gln Gly  Ser Arg Asn Leu Arg  Ala Ala His 
    1040                 1045                 1050             


Ala Leu  Glu His Thr Phe Ala  Pro Val Thr Asp Gly  Ala Ile Ser 
    1055                 1060                 1065             


Thr Leu  Leu Gly Leu Leu Met  Leu Ala Gly Ser His  Phe Asp Phe 
    1070                 1075                 1080             


Ile Val  Arg Tyr Phe Phe Ala  Ala Leu Thr Val Leu  Thr Leu Leu 
    1085                 1090                 1095             


Gly Leu  Leu His Gly Leu Val  Leu Leu Pro Val Leu  Leu Ser Ile 
    1100                 1105                 1110             


Leu Gly  Pro Pro Pro Glu Val  Ile Gln Met Tyr Lys  Glu Ser Pro 
    1115                 1120                 1125             


Glu Ile  Leu Ser Pro Pro Ala  Pro Gln Gly Gly Gly  Leu Arg Pro 
    1130                 1135                 1140             


Glu Glu  Ile 
    1145     


<210>  2159
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  2159

Met Ala Ala Arg Val Ala Ala Val Arg Ala Ala Ala Trp Leu Leu Leu 
1               5                   10                  15      


Gly Ala Ala Thr Gly Leu Thr Arg Gly Pro Ala Ala Ala Phe Thr Ala 
            20                  25                  30          


Ala Arg Ser Asp Ala Gly Ile Arg Ala Met Cys Ser Glu Ile Ile Leu 
        35                  40                  45              


Arg Gln Glu Val Leu Lys Asp Gly Phe His Arg Asp Leu Leu Ile Lys 
    50                  55                  60                  


Val Lys Phe Gly Glu Ser Ile Glu Asp Leu His Thr Cys Arg Leu Leu 
65                  70                  75                  80  


Ile Lys Gln Asp Ile Pro Ala Gly Leu Tyr Val Asp Pro Tyr Glu Leu 
                85                  90                  95      


Ala Ser Leu Arg Glu Arg Asn Ile Thr Glu Ala Val Met Val Ser Glu 
            100                 105                 110         


Asn Phe Asp Ile Glu Ala Pro Asn Tyr Leu Ser Lys Glu Ser Glu Val 
        115                 120                 125             


Leu Ile Tyr Ala Arg Arg Asp Ser Gln Cys Ile Asp Cys Phe Gln Ala 
    130                 135                 140                 


Phe Leu Pro Val His Cys Arg Tyr His Arg Pro His Ser Glu Asp Gly 
145                 150                 155                 160 


Glu Ala Ser Ile Val Val Asn Asn Pro Asp Leu Leu Met Phe Cys Asp 
                165                 170                 175     


Gln Ala Gly Ser Arg Arg Met Ile Arg Phe Arg Phe Asp Ser Phe Asp 
            180                 185                 190         


Lys Thr Ile Glu Phe Pro Ile Leu Lys Cys Trp Ala His Ser Glu Val 
        195                 200                 205             


Ala Ala Pro Cys Ala Leu Glu Asn Glu Asp Ile Cys Gln Trp Asn Lys 
    210                 215                 220                 


Met Lys Tyr Lys Ser Val Tyr Lys Asn Val Ile Leu Gln Val Pro Val 
225                 230                 235                 240 


Gly Leu Thr Val His Thr Ser Leu Val Cys Ser Val Thr Leu Leu Ile 
                245                 250                 255     


Thr Ile Leu Cys Ser Thr Leu Ile Leu Val Ala Val Phe Lys Tyr Gly 
            260                 265                 270         


His Phe Ser Leu 
        275     


<210>  2160
<211>  606
<212>  PRT
<213>  Homo sapiens

<400>  2160

Met Pro Ser Ser Val Thr Ala Leu Gly Gln Ala Arg Ser Ser Gly Pro 
1               5                   10                  15      


Gly Met Ala Pro Ser Ala Cys Cys Cys Ser Pro Ala Ala Leu Gln Arg 
            20                  25                  30          


Arg Leu Pro Ile Leu Ala Trp Leu Pro Ser Tyr Ser Leu Gln Trp Leu 
        35                  40                  45              


Lys Met Asp Phe Val Ala Gly Leu Ser Val Gly Leu Thr Ala Ile Pro 
    50                  55                  60                  


Gln Ala Leu Ala Tyr Ala Glu Val Ala Gly Leu Pro Pro Gln Tyr Gly 
65                  70                  75                  80  


Leu Tyr Ser Ala Phe Met Gly Cys Phe Val Tyr Phe Phe Leu Gly Thr 
                85                  90                  95      


Ser Arg Asp Val Thr Leu Gly Pro Thr Ala Ile Met Ser Leu Leu Val 
            100                 105                 110         


Ser Phe Tyr Thr Phe His Glu Pro Ala Tyr Ala Val Leu Leu Ala Phe 
        115                 120                 125             


Leu Ser Gly Cys Ile Gln Leu Ala Met Gly Val Leu Arg Leu Gly Phe 
    130                 135                 140                 


Leu Leu Asp Phe Ile Ser Tyr Pro Val Ile Lys Gly Phe Thr Ser Ala 
145                 150                 155                 160 


Ala Ala Val Thr Ile Gly Phe Gly Gln Ile Lys Asn Leu Leu Gly Leu 
                165                 170                 175     


Gln Asn Ile Pro Arg Pro Phe Phe Leu Gln Val Tyr His Thr Phe Leu 
            180                 185                 190         


Arg Ile Ala Glu Thr Arg Val Gly Asp Ala Val Leu Gly Leu Val Cys 
        195                 200                 205             


Met Leu Leu Leu Leu Val Leu Lys Leu Met Arg Asp His Val Pro Pro 
    210                 215                 220                 


Val His Pro Glu Met Pro Pro Gly Val Arg Leu Ser Arg Gly Leu Val 
225                 230                 235                 240 


Trp Ala Ala Thr Thr Ala Arg Asn Ala Leu Val Val Ser Phe Ala Ala 
                245                 250                 255     


Leu Val Ala Tyr Ser Phe Glu Val Thr Gly Tyr Gln Pro Phe Ile Leu 
            260                 265                 270         


Thr Gly Glu Thr Ala Glu Gly Leu Pro Pro Val Arg Ile Pro Pro Phe 
        275                 280                 285             


Ser Val Thr Thr Ala Asn Gly Thr Ile Ser Phe Thr Glu Met Val Gln 
    290                 295                 300                 


Asp Met Gly Ala Gly Leu Ala Val Val Pro Leu Met Gly Leu Leu Glu 
305                 310                 315                 320 


Ser Ile Ala Val Ala Lys Ala Phe Ala Ser Gln Asn Asn Tyr Arg Ile 
                325                 330                 335     


Asp Ala Asn Gln Glu Leu Leu Ala Ile Gly Leu Thr Asn Met Leu Gly 
            340                 345                 350         


Ser Leu Val Ser Ser Tyr Pro Val Thr Gly Ser Phe Gly Arg Thr Ala 
        355                 360                 365             


Val Asn Ala Gln Ser Gly Val Cys Thr Pro Ala Gly Gly Leu Val Thr 
    370                 375                 380                 


Gly Val Leu Val Leu Leu Ser Leu Asp Tyr Leu Thr Ser Leu Phe Tyr 
385                 390                 395                 400 


Tyr Ile Pro Lys Ser Ala Leu Ala Ala Val Ile Ile Met Ala Val Ala 
                405                 410                 415     


Pro Leu Phe Asp Thr Lys Ile Phe Arg Thr Leu Trp Arg Val Lys Arg 
            420                 425                 430         


Leu Asp Leu Leu Pro Leu Cys Val Thr Phe Leu Leu Cys Phe Trp Glu 
        435                 440                 445             


Val Gln Tyr Gly Ile Leu Ala Gly Ala Leu Val Ser Leu Leu Met Leu 
    450                 455                 460                 


Leu His Ser Ala Ala Arg Pro Glu Thr Lys Val Ser Glu Gly Pro Val 
465                 470                 475                 480 


Leu Val Leu Gln Pro Ala Ser Gly Leu Ser Phe Pro Ala Met Glu Ala 
                485                 490                 495     


Leu Arg Glu Glu Ile Leu Ser Arg Ala Leu Glu Val Ser Pro Pro Arg 
            500                 505                 510         


Cys Leu Val Leu Glu Cys Thr His Val Cys Ser Ile Asp Tyr Thr Val 
        515                 520                 525             


Val Leu Gly Leu Gly Glu Leu Leu Gln Asp Phe Gln Lys Gln Gly Val 
    530                 535                 540                 


Ala Leu Ala Phe Val Gly Leu Gln Val Pro Val Leu Arg Val Leu Leu 
545                 550                 555                 560 


Ser Ala Asp Leu Lys Gly Phe Gln Tyr Phe Ser Thr Leu Glu Glu Ala 
                565                 570                 575     


Glu Lys His Leu Arg Gln Glu Pro Gly Thr Gln Pro Tyr Asn Ile Arg 
            580                 585                 590         


Glu Asp Ser Ile Leu Asp Gln Lys Val Ala Leu Leu Lys Ala 
        595                 600                 605     


<210>  2161
<211>  606
<212>  PRT
<213>  Homo sapiens

<400>  2161

Met Pro Ser Ser Val Thr Ala Leu Gly Gln Ala Arg Ser Ser Gly Pro 
1               5                   10                  15      


Gly Met Ala Pro Ser Ala Cys Cys Cys Ser Pro Ala Ala Leu Gln Arg 
            20                  25                  30          


Arg Leu Pro Ile Leu Ala Trp Leu Pro Ser Tyr Ser Leu Gln Trp Leu 
        35                  40                  45              


Lys Met Asp Phe Val Ala Gly Leu Ser Val Gly Leu Thr Ala Ile Pro 
    50                  55                  60                  


Gln Ala Leu Ala Tyr Ala Glu Val Ala Gly Leu Pro Pro Gln Tyr Gly 
65                  70                  75                  80  


Leu Tyr Ser Ala Phe Met Gly Cys Phe Val Tyr Phe Phe Leu Gly Thr 
                85                  90                  95      


Ser Arg Asp Val Thr Leu Gly Pro Thr Ala Ile Met Ser Leu Leu Val 
            100                 105                 110         


Ser Phe Tyr Thr Phe His Glu Pro Ala Tyr Ala Val Leu Leu Ala Phe 
        115                 120                 125             


Leu Ser Gly Cys Ile Gln Leu Ala Met Gly Val Leu Arg Leu Gly Phe 
    130                 135                 140                 


Leu Leu Asp Phe Ile Ser Tyr Pro Val Ile Lys Gly Phe Thr Ser Ala 
145                 150                 155                 160 


Ala Ala Val Thr Ile Gly Phe Gly Gln Ile Lys Asn Leu Leu Gly Leu 
                165                 170                 175     


Gln Asn Ile Pro Arg Pro Phe Phe Leu Gln Val Tyr His Thr Phe Leu 
            180                 185                 190         


Arg Ile Ala Glu Thr Arg Val Gly Asp Ala Val Leu Gly Leu Val Cys 
        195                 200                 205             


Met Leu Leu Leu Leu Val Leu Lys Leu Met Arg Asp His Val Pro Pro 
    210                 215                 220                 


Val His Pro Glu Met Pro Pro Gly Val Arg Leu Ser Arg Gly Leu Val 
225                 230                 235                 240 


Trp Ala Ala Thr Thr Ala Arg Asn Ala Leu Val Val Ser Phe Ala Ala 
                245                 250                 255     


Leu Val Ala Tyr Ser Phe Glu Val Thr Gly Tyr Gln Pro Phe Ile Leu 
            260                 265                 270         


Thr Gly Glu Thr Ala Glu Gly Leu Pro Pro Val Arg Ile Pro Pro Phe 
        275                 280                 285             


Ser Val Thr Thr Ala Asn Gly Thr Ile Ser Phe Thr Glu Met Val Gln 
    290                 295                 300                 


Asp Met Gly Ala Gly Leu Ala Val Val Pro Leu Met Gly Leu Leu Glu 
305                 310                 315                 320 


Ser Ile Ala Val Ala Lys Ala Phe Ala Ser Gln Asn Asn Tyr Arg Ile 
                325                 330                 335     


Asp Ala Asn Gln Glu Leu Leu Ala Ile Gly Leu Thr Asn Met Leu Gly 
            340                 345                 350         


Ser Leu Val Ser Ser Tyr Pro Val Thr Gly Ser Phe Gly Arg Thr Ala 
        355                 360                 365             


Val Asn Ala Gln Ser Gly Val Cys Thr Pro Ala Gly Gly Leu Val Thr 
    370                 375                 380                 


Gly Val Leu Val Leu Leu Ser Leu Asp Tyr Leu Thr Ser Leu Phe Tyr 
385                 390                 395                 400 


Tyr Ile Pro Lys Ser Ala Leu Ala Ala Val Ile Ile Met Ala Val Ala 
                405                 410                 415     


Pro Leu Phe Asp Thr Lys Ile Phe Arg Thr Leu Trp Arg Val Lys Arg 
            420                 425                 430         


Leu Asp Leu Leu Pro Leu Cys Val Thr Phe Leu Leu Cys Phe Trp Glu 
        435                 440                 445             


Val Gln Tyr Gly Ile Leu Ala Gly Ala Leu Val Ser Leu Leu Met Leu 
    450                 455                 460                 


Leu His Ser Ala Ala Arg Pro Glu Thr Lys Val Ser Glu Gly Pro Val 
465                 470                 475                 480 


Leu Val Leu Gln Pro Ala Ser Gly Leu Ser Phe Pro Ala Met Glu Ala 
                485                 490                 495     


Leu Arg Glu Glu Ile Leu Ser Arg Ala Leu Glu Val Ser Pro Pro Arg 
            500                 505                 510         


Cys Leu Val Leu Glu Cys Thr His Val Cys Ser Ile Asp Tyr Thr Val 
        515                 520                 525             


Val Leu Gly Leu Gly Glu Leu Leu Gln Asp Phe Gln Lys Gln Gly Val 
    530                 535                 540                 


Ala Leu Ala Phe Val Gly Leu Gln Val Pro Val Leu Arg Val Leu Leu 
545                 550                 555                 560 


Ser Ala Asp Leu Lys Gly Phe Gln Tyr Phe Ser Thr Leu Glu Glu Ala 
                565                 570                 575     


Glu Lys His Leu Arg Gln Glu Pro Gly Thr Gln Pro Tyr Asn Ile Arg 
            580                 585                 590         


Glu Asp Ser Ile Leu Asp Gln Lys Val Ala Leu Leu Lys Ala 
        595                 600                 605     


<210>  2162
<211>  606
<212>  PRT
<213>  Homo sapiens

<400>  2162

Met Pro Ser Ser Val Thr Ala Leu Gly Gln Ala Arg Ser Ser Gly Pro 
1               5                   10                  15      


Gly Met Ala Pro Ser Ala Cys Cys Cys Ser Pro Ala Ala Leu Gln Arg 
            20                  25                  30          


Arg Leu Pro Ile Leu Ala Trp Leu Pro Ser Tyr Ser Leu Gln Trp Leu 
        35                  40                  45              


Lys Met Asp Phe Val Ala Gly Leu Ser Val Gly Leu Thr Ala Ile Pro 
    50                  55                  60                  


Gln Ala Leu Ala Tyr Ala Glu Val Ala Gly Leu Pro Pro Gln Tyr Gly 
65                  70                  75                  80  


Leu Tyr Ser Ala Phe Met Gly Cys Phe Val Tyr Phe Phe Leu Gly Thr 
                85                  90                  95      


Ser Arg Asp Val Thr Leu Gly Pro Thr Ala Ile Met Ser Leu Leu Val 
            100                 105                 110         


Ser Phe Tyr Thr Phe His Glu Pro Ala Tyr Ala Val Leu Leu Ala Phe 
        115                 120                 125             


Leu Ser Gly Cys Ile Gln Leu Ala Met Gly Val Leu Arg Leu Gly Phe 
    130                 135                 140                 


Leu Leu Asp Phe Ile Ser Tyr Pro Val Ile Lys Gly Phe Thr Ser Ala 
145                 150                 155                 160 


Ala Ala Val Thr Ile Gly Phe Gly Gln Ile Lys Asn Leu Leu Gly Leu 
                165                 170                 175     


Gln Asn Ile Pro Arg Pro Phe Phe Leu Gln Val Tyr His Thr Phe Leu 
            180                 185                 190         


Arg Ile Ala Glu Thr Arg Val Gly Asp Ala Val Leu Gly Leu Val Cys 
        195                 200                 205             


Met Leu Leu Leu Leu Val Leu Lys Leu Met Arg Asp His Val Pro Pro 
    210                 215                 220                 


Val His Pro Glu Met Pro Pro Gly Val Arg Leu Ser Arg Gly Leu Val 
225                 230                 235                 240 


Trp Ala Ala Thr Thr Ala Arg Asn Ala Leu Val Val Ser Phe Ala Ala 
                245                 250                 255     


Leu Val Ala Tyr Ser Phe Glu Val Thr Gly Tyr Gln Pro Phe Ile Leu 
            260                 265                 270         


Thr Gly Glu Thr Ala Glu Gly Leu Pro Pro Val Arg Ile Pro Pro Phe 
        275                 280                 285             


Ser Val Thr Thr Ala Asn Gly Thr Ile Ser Phe Thr Glu Met Val Gln 
    290                 295                 300                 


Asp Met Gly Ala Gly Leu Ala Val Val Pro Leu Met Gly Leu Leu Glu 
305                 310                 315                 320 


Ser Ile Ala Val Ala Lys Ala Phe Ala Ser Gln Asn Asn Tyr Arg Ile 
                325                 330                 335     


Asp Ala Asn Gln Glu Leu Leu Ala Ile Gly Leu Thr Asn Met Leu Gly 
            340                 345                 350         


Ser Leu Val Ser Ser Tyr Pro Val Thr Gly Ser Phe Gly Arg Thr Ala 
        355                 360                 365             


Val Asn Ala Gln Ser Gly Val Cys Thr Pro Ala Gly Gly Leu Val Thr 
    370                 375                 380                 


Gly Val Leu Val Leu Leu Ser Leu Asp Tyr Leu Thr Ser Leu Phe Tyr 
385                 390                 395                 400 


Tyr Ile Pro Lys Ser Ala Leu Ala Ala Val Ile Ile Met Ala Val Ala 
                405                 410                 415     


Pro Leu Phe Asp Thr Lys Ile Phe Arg Thr Leu Trp Arg Val Lys Arg 
            420                 425                 430         


Leu Asp Leu Leu Pro Leu Cys Val Thr Phe Leu Leu Cys Phe Trp Glu 
        435                 440                 445             


Val Gln Tyr Gly Ile Leu Ala Gly Ala Leu Val Ser Leu Leu Met Leu 
    450                 455                 460                 


Leu His Ser Ala Ala Arg Pro Glu Thr Lys Val Ser Glu Gly Pro Val 
465                 470                 475                 480 


Leu Val Leu Gln Pro Ala Ser Gly Leu Ser Phe Pro Ala Met Glu Ala 
                485                 490                 495     


Leu Arg Glu Glu Ile Leu Ser Arg Ala Leu Glu Val Ser Pro Pro Arg 
            500                 505                 510         


Cys Leu Val Leu Glu Cys Thr His Val Cys Ser Ile Asp Tyr Thr Val 
        515                 520                 525             


Val Leu Gly Leu Gly Glu Leu Leu Gln Asp Phe Gln Lys Gln Gly Val 
    530                 535                 540                 


Ala Leu Ala Phe Val Gly Leu Gln Val Pro Val Leu Arg Val Leu Leu 
545                 550                 555                 560 


Ser Ala Asp Leu Lys Gly Phe Gln Tyr Phe Ser Thr Leu Glu Glu Ala 
                565                 570                 575     


Glu Lys His Leu Arg Gln Glu Pro Gly Thr Gln Pro Tyr Asn Ile Arg 
            580                 585                 590         


Glu Asp Ser Ile Leu Asp Gln Lys Val Ala Leu Leu Lys Ala 
        595                 600                 605     


<210>  2163
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  2163

Met Asp Glu Gln Thr Gly Arg Leu Arg Leu Asp Thr Tyr Cys Met Ser 
1               5                   10                  15      


Ala Lys Gln Ile Trp Ala Trp Ser Lys Cys Ser Gly Arg Leu Trp Asp 
            20                  25                  30          


Glu His Met Lys Trp Met Glu Gly Trp Thr Asp Arg Trp Thr Asp Gly 
        35                  40                  45              


Trp Met Asp Gly Trp Met Asp Glu Trp Ser Pro Thr Pro Ala Leu Arg 
    50                  55                  60                  


Ser Tyr Gly Gly Gly Leu Ser Gln Gln Thr Phe Ile Phe Thr Asp Gly 
65                  70                  75                  80  


Glu Asp Glu Ala Leu Ala Arg His Thr Gly Asn Val Val Ile Thr Asn 
                85                  90                  95      


Cys Ser Ala Ala His Ser Arg Gln Ala Leu Ser Cys Lys Met Ala Val 
            100                 105                 110         


Glu Tyr Asp Arg Phe Ile Glu Ser Gly Arg Lys Trp Phe Cys His Val 
        115                 120                 125             


Asp Asp Asp Asn Tyr Val Asn Leu Arg Ala Leu Leu Arg Leu Leu Ala 
    130                 135                 140                 


Ser Tyr Pro His Thr Arg Asp Val Tyr Val Gly Lys Pro Ser Leu Asp 
145                 150                 155                 160 


Arg Pro Ile Gln Ala Met Glu Arg Val Ser Glu Asn Lys Val Arg Pro 
                165                 170                 175     


Val His Phe Trp Phe Ala Thr Gly Gly Ala Gly Phe Cys Ile Ser Arg 
            180                 185                 190         


Gly Leu Ala Leu Lys Met Ser Pro Trp Ala Ser Gly Gly His Phe Met 
        195                 200                 205             


Asn Thr Ala Glu Arg Ile Arg Leu Pro Asp Asp Cys Thr Ile Gly Tyr 
    210                 215                 220                 


Ile Val Glu Ala Leu Leu Gly Val Pro Leu Ile Arg Ser Gly Leu Phe 
225                 230                 235                 240 


His Ser His Leu Glu Asn Leu Gln Gln Val Pro Thr Ser Glu Leu His 
                245                 250                 255     


Glu Gln Val Thr Leu Ser Tyr Gly Met Phe Glu Asn Lys Arg Asn Ala 
            260                 265                 270         


Val His Val Lys Gly Pro Phe Ser Val Glu Ala Asp Pro Ser Arg Phe 
        275                 280                 285             


Arg Ser Ile His Cys His Leu Tyr Pro Asp Thr Pro Trp Cys Pro Arg 
    290                 295                 300                 


Thr Ala Ile Phe 
305             


<210>  2164
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  2164

Met Pro Gly Gly Cys Ser Arg Gly Pro Ala Ala Gly Asp Gly Arg Leu 
1               5                   10                  15      


Arg Leu Ala Arg Leu Ala Leu Val Leu Leu Gly Trp Val Ser Ser Ser 
            20                  25                  30          


Ser Pro Thr Ser Ser Ala Ser Ser Phe Ser Ser Ser Ala Pro Phe Leu 
        35                  40                  45              


Ala Ser Ala Val Ser Ala Gln Pro Pro Leu Pro Asp Gln Cys Pro Ala 
    50                  55                  60                  


Leu Cys Glu Cys Ser Glu Ala Ala Arg Thr Val Lys Cys Val Asn Arg 
65                  70                  75                  80  


Asn Leu Thr Glu Val Pro Thr Asp Leu Pro Ala Tyr Val Arg Asn Leu 
                85                  90                  95      


Phe Leu Thr Gly Asn Gln Leu Ala Val Leu Pro Ala Gly Ala Phe Ala 
            100                 105                 110         


Arg Arg Pro Pro Leu Ala Glu Leu Ala Ala Leu Asn Leu Ser Gly Ser 
        115                 120                 125             


Arg Leu Asp Glu Val Arg Ala Gly Ala Phe Glu His Leu Pro Ser Leu 
    130                 135                 140                 


Arg Gln Leu Asp Leu Ser His Asn Pro Leu Ala Asp Leu Ser Pro Phe 
145                 150                 155                 160 


Ala Phe Ser Gly Ser Asn Ala Ser Val Ser Ala Pro Ser Pro Leu Val 
                165                 170                 175     


Glu Leu Ile Leu Asn His Ile Val Pro Pro Glu Asp Glu Arg Gln Asn 
            180                 185                 190         


Arg Ser Phe Glu Gly Met Val Val Ala Ala Leu Leu Ala Gly Arg Ala 
        195                 200                 205             


Leu Gln Gly Leu Arg Arg Leu Glu Leu Ala Ser Asn His Phe Leu Tyr 
    210                 215                 220                 


Leu Pro Arg Asp Val Leu Ala Gln Leu Pro Ser Leu Arg His Leu Asp 
225                 230                 235                 240 


Leu Ser Asn Asn Ser Leu Val Ser Leu Thr Tyr Val Ser Phe Arg Asn 
                245                 250                 255     


Leu Thr His Leu Glu Ser Leu His Leu Glu Asp Asn Ala Leu Lys Val 
            260                 265                 270         


Leu His Asn Gly Thr Leu Ala Glu Leu Gln Gly Leu Pro His Ile Arg 
        275                 280                 285             


Val Phe Leu Asp Asn Asn Pro Trp Val Cys Asp Cys His Met Ala Asp 
    290                 295                 300                 


Met Val Thr Trp Leu Lys Glu Thr Glu Val Val Gln Gly Lys Asp Arg 
305                 310                 315                 320 


Leu Thr Cys Ala Tyr Pro Glu Lys Met Arg Asn Arg Val Leu Leu Glu 
                325                 330                 335     


Leu Asn Ser Ala Asp Leu Asp Cys Asp Pro Ile Leu Pro Pro Ser Leu 
            340                 345                 350         


Gln Thr Ser Tyr Val Phe Leu Gly Ile Val Leu Ala Leu Ile Gly Ala 
        355                 360                 365             


Ile Phe Leu Leu Val Leu Tyr Leu Asn Arg Lys Gly Ile Lys Lys Trp 
    370                 375                 380                 


Met His Asn Ile Arg Asp Ala Cys Arg Asp His Met Glu Gly Tyr His 
385                 390                 395                 400 


Tyr Arg Tyr Glu Ile Asn Ala Asp Pro Arg Leu Thr Asn Leu Ser Ser 
                405                 410                 415     


Asn Ser Asp Val 
            420 


<210>  2165
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  2165

Met Lys Thr Pro Pro Lys Gly Pro Ser Arg Lys Asn Leu Phe Thr Ala 
1               5                   10                  15      


Leu Asn Ala Val Glu Lys Ser Arg Gln Lys Asn Pro Arg Ser Leu Cys 
            20                  25                  30          


Ile Gln Pro Gln Thr Ala Pro Asp Ala Leu Pro Pro Glu Lys Thr Leu 
        35                  40                  45              


Glu Leu Thr Gln Tyr Lys Thr Lys Cys Glu Asn Gln Ser Gly Phe Ile 
    50                  55                  60                  


Leu Gln Leu Lys Gln Leu Leu Ala Cys Gly Asn Thr Lys Phe Glu Ala 
65                  70                  75                  80  


Leu Thr Val Val Ile Gln His Leu Leu Ser Glu Arg Glu Glu Ala Leu 
                85                  90                  95      


Lys Gln His Lys Thr Leu Ser Gln Glu Leu Val Asn Leu Arg Gly Glu 
            100                 105                 110         


Leu Val Thr Ala Ser Thr Thr Cys Glu Lys Leu Glu Lys Ala Arg Asn 
        115                 120                 125             


Glu Leu Gln Thr Val Tyr Glu Ala Phe Val Gln Gln His Gln Ala Glu 
    130                 135                 140                 


Lys Thr Glu Arg Glu Asn Arg Leu Lys Glu Phe Tyr Thr Arg Glu Tyr 
145                 150                 155                 160 


Glu Lys Leu Arg Asp Thr Tyr Ile Glu Glu Ala Glu Lys Tyr Lys Met 
                165                 170                 175     


Gln Leu Gln Glu Gln Phe Asp Asn Leu Asn Ala Ala His Glu Thr Ser 
            180                 185                 190         


Lys Leu Glu Ile Glu Ala Ser His Ser Glu Lys Leu Glu Leu Leu Lys 
        195                 200                 205             


Lys Ala Tyr Glu Ala Ser Leu Ser Glu Ile Lys Lys Gly His Glu Ile 
    210                 215                 220                 


Glu Lys Lys Ser Leu Glu Asp Leu Leu Ser Glu Lys Gln Glu Ser Leu 
225                 230                 235                 240 


Glu Lys Gln Ile Asn Asp Leu Lys Ser Glu Asn Asp Ala Leu Asn Glu 
                245                 250                 255     


Lys Leu Lys Ser Glu Glu Gln Lys Arg Arg Ala Arg Glu Lys Ala Asn 
            260                 265                 270         


Leu Lys Asn Pro Gln Ile Met Tyr Leu Glu Gln Glu Leu Glu Ser Leu 
        275                 280                 285             


Lys Ala Val Leu Glu Ile Lys Asn Glu Lys Leu His Gln Gln Asp Ile 
    290                 295                 300                 


Lys Leu Met Lys Met Glu Lys Leu Val Asp Asn Asn Thr Ala Leu Val 
305                 310                 315                 320 


Asp Lys Leu Lys Arg Phe Gln Gln Glu Asn Glu Glu Leu Lys Ala Arg 
                325                 330                 335     


Met Asp Lys His Met Ala Ile Ser Arg Gln Leu Ser Thr Glu Gln Ala 
            340                 345                 350         


Val Leu Gln Glu Ser Leu Glu Lys Glu Ser Lys Val Asn Lys Arg Leu 
        355                 360                 365             


Ser Met Glu Asn Glu Glu Leu Leu Trp Lys Leu His Asn Gly Asp Leu 
    370                 375                 380                 


Cys Ser Pro Lys Arg Ser Pro Thr Ser Ser Ala Ile Pro Leu Gln Ser 
385                 390                 395                 400 


Pro Arg Asn Ser Gly Ser Phe Pro Ser Pro Ser Ile Ser Pro Arg 
                405                 410                 415 


<210>  2166
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  2166

Met Leu Leu Pro Lys Lys Met Lys Leu Leu Leu Phe Leu Val Ser Gln 
1               5                   10                  15      


Met Ala Ile Leu Ala Leu Phe Phe His Met Tyr Ser His Asn Ile Ser 
            20                  25                  30          


Ser Leu Ser Met Lys Ala Gln Pro Glu Arg Met His Val Leu Val Leu 
        35                  40                  45              


Ser Ser Trp Arg Ser Gly Ser Ser Phe Val Gly Gln Leu Phe Gly Gln 
    50                  55                  60                  


His Pro Asp Val Phe Tyr Leu Met Glu Pro Ala Trp His Val Trp Met 
65                  70                  75                  80  


Thr Phe Lys Gln Ser Thr Ala Trp Met Leu His Met Ala Val Arg Asp 
                85                  90                  95      


Leu Ile Arg Ala Val Phe Leu Cys Asp Met Ser Val Phe Asp Ala Tyr 
            100                 105                 110         


Met Glu Pro Gly Pro Arg Arg Gln Ser Ser Leu Phe Gln Trp Glu Asn 
        115                 120                 125             


Ser Arg Ala Leu Cys Ser Ala Pro Ala Cys Asp Ile Ile Pro Gln Asp 
    130                 135                 140                 


Glu Ile Ile Pro Arg Ala His Cys Arg Leu Leu Cys Ser Gln Gln Pro 
145                 150                 155                 160 


Phe Glu Val Val Glu Lys Ala Cys Arg Ser Tyr Ser His Val Val Leu 
                165                 170                 175     


Lys Glu Val Arg Phe Phe Asn Leu Gln Ser Leu Tyr Pro Leu Leu Lys 
            180                 185                 190         


Asp Pro Ser Leu Asn Leu His Ile Val His Leu Val Arg Asp Pro Arg 
        195                 200                 205             


Ala Val Phe Arg Ser Arg Glu Arg Thr Lys Gly Asp Leu Met Ile Asp 
    210                 215                 220                 


Ser Arg Ile Val Met Gly Gln His Glu Gln Lys Leu Lys Lys Glu Asp 
225                 230                 235                 240 


Gln Pro Tyr Tyr Val Met Gln Val Ile Cys Gln Ser Gln Leu Glu Ile 
                245                 250                 255     


Tyr Lys Thr Ile Gln Ser Leu Pro Lys Ala Leu Gln Glu Arg Tyr Leu 
            260                 265                 270         


Leu Val Arg Tyr Glu Asp Leu Ala Arg Ala Pro Val Ala Gln Thr Ser 
        275                 280                 285             


Arg Met Tyr Glu Phe Val Gly Leu Glu Phe Leu Pro His Leu Gln Thr 
    290                 295                 300                 


Trp Val His Asn Ile Thr Arg Gly Lys Gly Met Gly Asp His Ala Phe 
305                 310                 315                 320 


His Thr Asn Ala Arg Asp Ala Leu Asn Val Ser Gln Ala Trp Arg Trp 
                325                 330                 335     


Ser Leu Pro Tyr Glu Lys Val Ser Arg Leu Gln Lys Ala Cys Gly Asp 
            340                 345                 350         


Ala Met Asn Leu Leu Gly Tyr Arg His Val Arg Ser Glu Gln Glu Gln 
        355                 360                 365             


Arg Asn Leu Leu Leu Asp Leu Leu Ser Thr Trp Thr Val Pro Glu Gln 
    370                 375                 380                 


Ile His 
385     


<210>  2167
<211>  446
<212>  PRT
<213>  Homo sapiens

<400>  2167

Met Leu Leu Pro Gln Leu Cys Trp Leu Pro Leu Leu Ala Gly Leu Leu 
1               5                   10                  15      


Pro Pro Val Pro Ala Gln Lys Phe Ser Ala Leu Thr Phe Leu Arg Val 
            20                  25                  30          


Asp Gln Asp Lys Asp Lys Asp Cys Ser Leu Asp Cys Ala Gly Ser Pro 
        35                  40                  45              


Gln Lys Pro Leu Cys Ala Ser Asp Gly Arg Thr Phe Leu Ser Arg Cys 
    50                  55                  60                  


Glu Phe Gln Arg Ala Lys Cys Lys Asp Pro Gln Leu Glu Ile Ala Tyr 
65                  70                  75                  80  


Arg Gly Asn Cys Lys Asp Val Ser Arg Cys Val Ala Glu Arg Lys Tyr 
                85                  90                  95      


Thr Gln Glu Gln Ala Arg Lys Glu Phe Gln Gln Val Phe Ile Pro Glu 
            100                 105                 110         


Cys Asn Asp Asp Gly Thr Tyr Ser Gln Val Gln Cys His Ser Tyr Thr 
        115                 120                 125             


Gly Tyr Cys Trp Cys Val Thr Pro Asn Gly Arg Pro Ile Ser Gly Thr 
    130                 135                 140                 


Ala Val Ala His Lys Thr Pro Arg Cys Pro Gly Ser Val Asn Glu Lys 
145                 150                 155                 160 


Leu Pro Gln Arg Glu Gly Thr Gly Lys Thr Asp Asp Ala Ala Ala Pro 
                165                 170                 175     


Ala Leu Glu Thr Gln Pro Gln Gly Asp Glu Glu Asp Ile Ala Ser Arg 
            180                 185                 190         


Tyr Pro Thr Leu Trp Thr Glu Gln Val Lys Ser Arg Gln Asn Lys Thr 
        195                 200                 205             


Asn Lys Asn Ser Val Ser Ser Cys Asp Gln Glu His Gln Ser Ala Leu 
    210                 215                 220                 


Glu Glu Ala Lys Gln Pro Lys Asn Asp Asn Val Val Ile Pro Glu Cys 
225                 230                 235                 240 


Ala His Gly Gly Leu Tyr Lys Pro Val Gln Cys His Pro Ser Thr Gly 
                245                 250                 255     


Tyr Cys Trp Cys Val Leu Val Asp Thr Gly Arg Pro Ile Pro Gly Thr 
            260                 265                 270         


Ser Thr Arg Tyr Glu Gln Pro Lys Cys Asp Asn Thr Ala Arg Ala His 
        275                 280                 285             


Pro Ala Lys Ala Arg Asp Leu Tyr Lys Gly Arg Gln Leu Gln Gly Cys 
    290                 295                 300                 


Pro Gly Ala Lys Lys His Glu Phe Leu Thr Ser Val Leu Asp Ala Leu 
305                 310                 315                 320 


Ser Thr Asp Met Val His Ala Ala Ser Asp Pro Ser Ser Ser Ser Gly 
                325                 330                 335     


Arg Leu Ser Glu Pro Asp Pro Ser His Thr Leu Glu Glu Arg Val Val 
            340                 345                 350         


His Trp Tyr Phe Lys Leu Leu Asp Lys Asn Ser Ser Gly Asp Ile Gly 
        355                 360                 365             


Lys Lys Glu Ile Lys Pro Phe Lys Arg Phe Leu Arg Lys Lys Ser Lys 
    370                 375                 380                 


Pro Lys Lys Cys Val Lys Lys Phe Val Glu Tyr Cys Asp Val Asn Asn 
385                 390                 395                 400 


Asp Lys Ser Ile Ser Val Gln Glu Leu Met Gly Cys Leu Gly Val Ala 
                405                 410                 415     


Lys Glu Asp Gly Lys Ala Asp Thr Lys Lys Arg His Thr Pro Arg Gly 
            420                 425                 430         


His Ala Glu Ser Thr Ser Asn Arg Gln Pro Arg Lys Gln Gly 
        435                 440                 445     


<210>  2168
<211>  769
<212>  PRT
<213>  Homo sapiens

<400>  2168

Met Glu Gln Phe Thr Ile His Leu Thr Val Asn Pro Gln Ser Lys Val 
1               5                   10                  15      


Thr Phe Gln Leu Thr Tyr Glu Glu Val Leu Lys Arg Asn His Met Gln 
            20                  25                  30          


Tyr Glu Ile Val Ile Lys Val Lys Pro Lys Gln Leu Val His His Phe 
        35                  40                  45              


Glu Ile Asp Val Asp Ile Phe Glu Pro Gln Gly Ile Ser Lys Leu Asp 
    50                  55                  60                  


Ala Gln Ala Ser Phe Leu Pro Lys Glu Leu Ala Ala Gln Thr Ile Lys 
65                  70                  75                  80  


Lys Ser Phe Ser Gly Lys Lys Gly His Val Leu Phe Arg Pro Thr Val 
                85                  90                  95      


Ser Gln Gln Gln Ser Cys Pro Thr Cys Ser Thr Ser Leu Leu Asn Gly 
            100                 105                 110         


His Phe Lys Val Thr Tyr Asp Val Ser Arg Asp Lys Ile Cys Asp Leu 
        115                 120                 125             


Leu Val Ala Asn Asn His Phe Ala His Phe Phe Ala Pro Gln Asn Leu 
    130                 135                 140                 


Thr Asn Met Asn Lys Asn Val Val Phe Val Ile Asp Ile Ser Gly Ser 
145                 150                 155                 160 


Met Arg Gly Gln Lys Val Lys Gln Thr Lys Glu Ala Leu Leu Lys Ile 
                165                 170                 175     


Leu Gly Asp Met Gln Pro Gly Asp Tyr Phe Asp Leu Val Leu Phe Gly 
            180                 185                 190         


Thr Arg Val Gln Ser Trp Lys Gly Ser Leu Val Gln Ala Ser Glu Ala 
        195                 200                 205             


Asn Leu Gln Ala Ala Gln Asp Phe Val Arg Gly Phe Ser Leu Asp Glu 
    210                 215                 220                 


Ala Thr Asn Leu Asn Gly Gly Leu Leu Arg Gly Ile Glu Ile Leu Asn 
225                 230                 235                 240 


Gln Val Gln Glu Ser Leu Pro Glu Leu Ser Asn His Ala Ser Ile Leu 
                245                 250                 255     


Ile Met Leu Thr Asp Gly Asp Pro Thr Glu Gly Val Thr Asp Arg Ser 
            260                 265                 270         


Gln Ile Leu Lys Asn Val Arg Asn Ala Ile Arg Gly Arg Phe Pro Leu 
        275                 280                 285             


Tyr Asn Leu Gly Phe Gly His Asn Val Asp Phe Asn Phe Leu Glu Val 
    290                 295                 300                 


Met Ser Met Glu Asn Asn Gly Arg Ala Gln Arg Ile Tyr Glu Asp His 
305                 310                 315                 320 


Asp Ala Thr Gln Gln Leu Gln Gly Phe Tyr Ser Gln Val Ala Lys Pro 
                325                 330                 335     


Leu Leu Val Asp Val Asp Leu Gln Tyr Pro Gln Asp Ala Val Leu Ala 
            340                 345                 350         


Leu Thr Gln Asn His His Lys Gln Tyr Tyr Glu Gly Ser Glu Ile Val 
        355                 360                 365             


Val Ala Gly Arg Ile Ala Asp Asn Lys Gln Ser Ser Phe Lys Ala Asp 
    370                 375                 380                 


Val Gln Ala His Gly Glu Gly Gln Glu Phe Ser Ile Thr Cys Leu Val 
385                 390                 395                 400 


Asp Glu Glu Glu Met Lys Lys Leu Leu Arg Glu Arg Gly His Met Leu 
                405                 410                 415     


Glu Asn His Val Glu Arg Leu Trp Ala Tyr Leu Thr Ile Gln Glu Leu 
            420                 425                 430         


Leu Ala Lys Arg Met Lys Val Asp Arg Glu Glu Arg Ala Asn Leu Ser 
        435                 440                 445             


Ser Gln Ala Leu Gln Met Ser Leu Asp Tyr Gly Phe Val Thr Pro Leu 
    450                 455                 460                 


Thr Ser Met Ser Ile Arg Gly Met Ala Asp Gln Asp Gly Leu Lys Pro 
465                 470                 475                 480 


Thr Ile Asp Lys Pro Ser Glu Asp Ser Pro Pro Leu Glu Met Leu Gly 
                485                 490                 495     


Pro Arg Arg Thr Phe Val Leu Ser Ala Leu Gln Pro Ser Pro Thr His 
            500                 505                 510         


Ser Ser Ser Asn Thr Gln Arg Leu Pro Asp Arg Val Thr Gly Val Asp 
        515                 520                 525             


Thr Asp Pro His Phe Ile Ile His Val Pro Gln Lys Glu Asp Thr Leu 
    530                 535                 540                 


Cys Phe Asn Ile Asn Glu Glu Pro Gly Val Ile Leu Ser Leu Val Gln 
545                 550                 555                 560 


Asp Pro Asn Thr Gly Phe Ser Val Asn Gly Gln Leu Ile Gly Asn Lys 
                565                 570                 575     


Ala Arg Ser Pro Gly Gln His Asp Gly Thr Tyr Phe Gly Arg Leu Gly 
            580                 585                 590         


Ile Ala Asn Pro Ala Thr Asp Phe Gln Leu Glu Val Thr Pro Gln Asn 
        595                 600                 605             


Ile Thr Leu Asn Pro Gly Phe Gly Gly Pro Val Phe Ser Trp Arg Asp 
    610                 615                 620                 


Gln Ala Val Leu Arg Gln Asp Gly Val Val Val Thr Ile Asn Lys Lys 
625                 630                 635                 640 


Arg Asn Leu Val Val Ser Val Asp Asp Gly Gly Thr Phe Glu Val Val 
                645                 650                 655     


Leu His Arg Val Trp Lys Gly Ser Ser Val His Gln Asp Phe Leu Gly 
            660                 665                 670         


Phe Tyr Val Leu Asp Ser His Arg Met Ser Ala Arg Thr His Gly Leu 
        675                 680                 685             


Leu Gly Gln Phe Phe His Pro Ile Gly Phe Glu Val Ser Asp Ile His 
    690                 695                 700                 


Pro Gly Ser Asp Pro Thr Lys Pro Asp Ala Thr Met Val Val Arg Asn 
705                 710                 715                 720 


Arg Arg Leu Thr Val Thr Arg Gly Leu Gln Lys Asp Tyr Ser Lys Asp 
                725                 730                 735     


Pro Trp His Gly Ala Glu Val Ser Cys Trp Phe Ile His Asn Asn Gly 
            740                 745                 750         


Ala Gly Leu Ile Asp Gly Ala Tyr Thr Asp Tyr Ile Val Pro Asp Ile 
        755                 760                 765             


Phe 
    


<210>  2169
<211>  623
<212>  PRT
<213>  Homo sapiens

<400>  2169

Met Asn Lys Asn Val Val Phe Val Ile Asp Ile Ser Gly Ser Met Arg 
1               5                   10                  15      


Gly Gln Lys Val Lys Gln Thr Lys Glu Ala Leu Leu Lys Ile Leu Gly 
            20                  25                  30          


Asp Met Gln Pro Gly Asp Tyr Phe Asp Leu Val Leu Phe Gly Thr Arg 
        35                  40                  45              


Val Gln Ser Trp Lys Gly Ser Leu Val Gln Ala Ser Glu Ala Asn Leu 
    50                  55                  60                  


Gln Ala Ala Gln Asp Phe Val Arg Gly Phe Ser Leu Asp Glu Ala Thr 
65                  70                  75                  80  


Asn Leu Asn Gly Gly Leu Leu Arg Gly Ile Glu Ile Leu Asn Gln Val 
                85                  90                  95      


Gln Glu Ser Leu Pro Glu Leu Ser Asn His Ala Ser Ile Leu Ile Met 
            100                 105                 110         


Leu Thr Asp Gly Asp Pro Thr Glu Gly Val Thr Asp Arg Ser Gln Ile 
        115                 120                 125             


Leu Lys Asn Val Arg Asn Ala Ile Arg Gly Arg Phe Pro Leu Tyr Asn 
    130                 135                 140                 


Leu Gly Phe Gly His Asn Val Asp Phe Asn Phe Leu Glu Val Met Ser 
145                 150                 155                 160 


Met Glu Asn Asn Gly Arg Ala Gln Arg Ile Tyr Glu Asp His Asp Ala 
                165                 170                 175     


Thr Gln Gln Leu Gln Gly Phe Tyr Ser Gln Val Ala Lys Pro Leu Leu 
            180                 185                 190         


Val Asp Val Asp Leu Gln Tyr Pro Gln Asp Ala Val Leu Ala Leu Thr 
        195                 200                 205             


Gln Asn His His Lys Gln Tyr Tyr Glu Gly Ser Glu Ile Val Val Ala 
    210                 215                 220                 


Gly Arg Ile Ala Asp Asn Lys Gln Ser Ser Phe Lys Ala Asp Val Gln 
225                 230                 235                 240 


Ala His Gly Glu Gly Gln Glu Phe Ser Ile Thr Cys Leu Val Asp Glu 
                245                 250                 255     


Glu Glu Met Lys Lys Leu Leu Arg Glu Arg Gly His Met Leu Glu Asn 
            260                 265                 270         


His Val Glu Arg Leu Trp Ala Tyr Leu Thr Ile Gln Glu Leu Leu Ala 
        275                 280                 285             


Lys Arg Met Lys Val Asp Arg Glu Glu Arg Ala Asn Leu Ser Ser Gln 
    290                 295                 300                 


Ala Leu Gln Met Ser Leu Asp Tyr Gly Phe Val Thr Pro Leu Thr Ser 
305                 310                 315                 320 


Met Ser Ile Arg Gly Met Ala Asp Gln Asp Gly Leu Lys Pro Thr Ile 
                325                 330                 335     


Asp Lys Pro Ser Glu Asp Ser Pro Pro Leu Glu Met Leu Gly Pro Arg 
            340                 345                 350         


Arg Thr Phe Val Leu Ser Ala Leu Gln Pro Ser Pro Thr His Ser Ser 
        355                 360                 365             


Ser Asn Thr Gln Arg Leu Pro Asp Arg Val Thr Gly Val Asp Thr Asp 
    370                 375                 380                 


Pro His Phe Ile Ile His Val Pro Gln Lys Glu Asp Thr Leu Cys Phe 
385                 390                 395                 400 


Asn Ile Asn Glu Glu Pro Gly Val Ile Leu Ser Leu Val Gln Asp Pro 
                405                 410                 415     


Asn Thr Gly Phe Ser Val Asn Gly Gln Leu Ile Gly Asn Lys Ala Arg 
            420                 425                 430         


Ser Pro Gly Gln His Asp Gly Thr Tyr Phe Gly Arg Leu Gly Ile Ala 
        435                 440                 445             


Asn Pro Ala Thr Asp Phe Gln Leu Glu Val Thr Pro Gln Asn Ile Thr 
    450                 455                 460                 


Leu Asn Pro Gly Phe Gly Gly Pro Val Phe Ser Trp Arg Asp Gln Ala 
465                 470                 475                 480 


Val Leu Arg Gln Asp Gly Val Val Val Thr Ile Asn Lys Lys Arg Asn 
                485                 490                 495     


Leu Val Val Ser Val Asp Asp Gly Gly Thr Phe Glu Val Val Leu His 
            500                 505                 510         


Arg Val Trp Lys Gly Ser Ser Val His Gln Asp Phe Leu Gly Phe Tyr 
        515                 520                 525             


Val Leu Asp Ser His Arg Met Ser Ala Arg Thr His Gly Leu Leu Gly 
    530                 535                 540                 


Gln Phe Phe His Pro Ile Gly Phe Glu Val Ser Asp Ile His Pro Gly 
545                 550                 555                 560 


Ser Asp Pro Thr Lys Pro Asp Ala Thr Met Val Val Arg Asn Arg Arg 
                565                 570                 575     


Leu Thr Val Thr Arg Gly Leu Gln Lys Asp Tyr Ser Lys Asp Pro Trp 
            580                 585                 590         


His Gly Ala Glu Val Ser Cys Trp Phe Ile His Asn Asn Gly Ala Gly 
        595                 600                 605             


Leu Ile Asp Gly Ala Tyr Thr Asp Tyr Ile Val Pro Asp Ile Phe 
    610                 615                 620             


<210>  2170
<211>  623
<212>  PRT
<213>  Homo sapiens

<400>  2170

Met Asn Lys Asn Val Val Phe Val Ile Asp Ile Ser Gly Ser Met Arg 
1               5                   10                  15      


Gly Gln Lys Val Lys Gln Thr Lys Glu Ala Leu Leu Lys Ile Leu Gly 
            20                  25                  30          


Asp Met Gln Pro Gly Asp Tyr Phe Asp Leu Val Leu Phe Gly Thr Arg 
        35                  40                  45              


Val Gln Ser Trp Lys Gly Ser Leu Val Gln Ala Ser Glu Ala Asn Leu 
    50                  55                  60                  


Gln Ala Ala Gln Asp Phe Val Arg Gly Phe Ser Leu Asp Glu Ala Thr 
65                  70                  75                  80  


Asn Leu Asn Gly Gly Leu Leu Arg Gly Ile Glu Ile Leu Asn Gln Val 
                85                  90                  95      


Gln Glu Ser Leu Pro Glu Leu Ser Asn His Ala Ser Ile Leu Ile Met 
            100                 105                 110         


Leu Thr Asp Gly Asp Pro Thr Glu Gly Val Thr Asp Arg Ser Gln Ile 
        115                 120                 125             


Leu Lys Asn Val Arg Asn Ala Ile Arg Gly Arg Phe Pro Leu Tyr Asn 
    130                 135                 140                 


Leu Gly Phe Gly His Asn Val Asp Phe Asn Phe Leu Glu Val Met Ser 
145                 150                 155                 160 


Met Glu Asn Asn Gly Arg Ala Gln Arg Ile Tyr Glu Asp His Asp Ala 
                165                 170                 175     


Thr Gln Gln Leu Gln Gly Phe Tyr Ser Gln Val Ala Lys Pro Leu Leu 
            180                 185                 190         


Val Asp Val Asp Leu Gln Tyr Pro Gln Asp Ala Val Leu Ala Leu Thr 
        195                 200                 205             


Gln Asn His His Lys Gln Tyr Tyr Glu Gly Ser Glu Ile Val Val Ala 
    210                 215                 220                 


Gly Arg Ile Ala Asp Asn Lys Gln Ser Ser Phe Lys Ala Asp Val Gln 
225                 230                 235                 240 


Ala His Gly Glu Gly Gln Glu Phe Ser Ile Thr Cys Leu Val Asp Glu 
                245                 250                 255     


Glu Glu Met Lys Lys Leu Leu Arg Glu Arg Gly His Met Leu Glu Asn 
            260                 265                 270         


His Val Glu Arg Leu Trp Ala Tyr Leu Thr Ile Gln Glu Leu Leu Ala 
        275                 280                 285             


Lys Arg Met Lys Val Asp Arg Glu Glu Arg Ala Asn Leu Ser Ser Gln 
    290                 295                 300                 


Ala Leu Gln Met Ser Leu Asp Tyr Gly Phe Val Thr Pro Leu Thr Ser 
305                 310                 315                 320 


Met Ser Ile Arg Gly Met Ala Asp Gln Asp Gly Leu Lys Pro Thr Ile 
                325                 330                 335     


Asp Lys Pro Ser Glu Asp Ser Pro Pro Leu Glu Met Leu Gly Pro Arg 
            340                 345                 350         


Arg Thr Phe Val Leu Ser Ala Leu Gln Pro Ser Pro Thr His Ser Ser 
        355                 360                 365             


Ser Asn Thr Gln Arg Leu Pro Asp Arg Val Thr Gly Val Asp Thr Asp 
    370                 375                 380                 


Pro His Phe Ile Ile His Val Pro Gln Lys Glu Asp Thr Leu Cys Phe 
385                 390                 395                 400 


Asn Ile Asn Glu Glu Pro Gly Val Ile Leu Ser Leu Val Gln Asp Pro 
                405                 410                 415     


Asn Thr Gly Phe Ser Val Asn Gly Gln Leu Ile Gly Asn Lys Ala Arg 
            420                 425                 430         


Ser Pro Gly Gln His Asp Gly Thr Tyr Phe Gly Arg Leu Gly Ile Ala 
        435                 440                 445             


Asn Pro Ala Thr Asp Phe Gln Leu Glu Val Thr Pro Gln Asn Ile Thr 
    450                 455                 460                 


Leu Asn Pro Gly Phe Gly Gly Pro Val Phe Ser Trp Arg Asp Gln Ala 
465                 470                 475                 480 


Val Leu Arg Gln Asp Gly Val Val Val Thr Ile Asn Lys Lys Arg Asn 
                485                 490                 495     


Leu Val Val Ser Val Asp Asp Gly Gly Thr Phe Glu Val Val Leu His 
            500                 505                 510         


Arg Val Trp Lys Gly Ser Ser Val His Gln Asp Phe Leu Gly Phe Tyr 
        515                 520                 525             


Val Leu Asp Ser His Arg Met Ser Ala Arg Thr His Gly Leu Leu Gly 
    530                 535                 540                 


Gln Phe Phe His Pro Ile Gly Phe Glu Val Ser Asp Ile His Pro Gly 
545                 550                 555                 560 


Ser Asp Pro Thr Lys Pro Asp Ala Thr Met Val Val Arg Asn Arg Arg 
                565                 570                 575     


Leu Thr Val Thr Arg Gly Leu Gln Lys Asp Tyr Ser Lys Asp Pro Trp 
            580                 585                 590         


His Gly Ala Glu Val Ser Cys Trp Phe Ile His Asn Asn Gly Ala Gly 
        595                 600                 605             


Leu Ile Asp Gly Ala Tyr Thr Asp Tyr Ile Val Pro Asp Ile Phe 
    610                 615                 620             


<210>  2171
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  2171

Met Pro Pro Ala Val Gly Gly Pro Val Gly Tyr Thr Pro Pro Asp Gly 
1               5                   10                  15      


Gly Trp Gly Trp Ala Val Val Ile Gly Ala Phe Ile Ser Ile Gly Phe 
            20                  25                  30          


Ser Tyr Ala Phe Pro Lys Ser Ile Thr Val Phe Phe Lys Glu Ile Glu 
        35                  40                  45              


Gly Ile Phe His Ala Thr Thr Ser Glu Val Ser Trp Ile Ser Ser Ile 
    50                  55                  60                  


Met Leu Ala Val Met Tyr Gly Gly Gly Pro Ile Ser Ser Ile Leu Val 
65                  70                  75                  80  


Asn Lys Tyr Gly Ser Arg Ile Val Met Ile Val Gly Gly Cys Leu Ser 
                85                  90                  95      


Gly Cys Gly Leu Ile Ala Ala Ser Phe Cys Asn Thr Val Gln Gln Leu 
            100                 105                 110         


Tyr Val Cys Ile Gly Val Ile Gly Gly Leu Gly Leu Ala Phe Asn Leu 
        115                 120                 125             


Asn Pro Ala Leu Thr Met Ile Gly Lys Tyr Phe Tyr Lys Arg Arg Pro 
    130                 135                 140                 


Leu Ala Asn Gly Leu Ala Met Ala Gly Ser Pro Val Phe Leu Cys Thr 
145                 150                 155                 160 


Leu Ala Pro Leu Asn Gln Val Phe Phe Gly Ile Phe Gly Trp Arg Gly 
                165                 170                 175     


Ser Phe Leu Ile Leu Gly Gly Leu Leu Leu Asn Cys Cys Val Ala Gly 
            180                 185                 190         


Ala Leu Met Arg Pro Ile Gly Pro Lys Pro Thr Lys Ala Gly Lys Asp 
        195                 200                 205             


Lys Ser Lys Ala Ser Leu Glu Lys Ala Gly Lys Ser Gly Val Lys Lys 
    210                 215                 220                 


Asp Leu His Asp Ala Asn Thr Asp Leu Ile Gly Arg His Pro Lys Gln 
225                 230                 235                 240 


Glu Lys Arg Ser Val Phe Gln Thr Ile Asn Gln Phe Leu Asp Leu Thr 
                245                 250                 255     


Leu Phe Thr His Arg Gly Phe Leu Leu Tyr Leu Ser Gly Asn Val Ile 
            260                 265                 270         


Met Phe Phe Gly Leu Phe Ala Pro Leu Val Phe Leu Ser Ser Tyr Gly 
        275                 280                 285             


Lys Ser Gln His Tyr Ser Ser Glu Lys Ser Ala Phe Leu Leu Ser Ile 
    290                 295                 300                 


Leu Ala Phe Val Asp Met Val Ala Arg Pro Ser Met Gly Leu Val Ala 
305                 310                 315                 320 


Asn Thr Lys Pro Ile Arg Pro Arg Ile Gln Tyr Phe Phe Ala Ala Ser 
                325                 330                 335     


Val Val Ala Asn Gly Val Cys His Met Leu Ala Pro Leu Ser Thr Thr 
            340                 345                 350         


Tyr Val Gly Phe Cys Val Tyr Ala Gly Phe Phe Gly Phe Ala Phe Gly 
        355                 360                 365             


Trp Leu Ser Ser Val Leu Phe Glu Thr Leu Met Asp Leu Val Gly Pro 
    370                 375                 380                 


Gln Arg Phe Ser Ser Ala Val Gly Leu Val Thr Ile Val Glu Cys Cys 
385                 390                 395                 400 


Pro Val Leu Leu Gly Pro Pro Leu Leu Gly Arg Leu Asn Asp Met Tyr 
                405                 410                 415     


Gly Asp Tyr Lys Tyr Thr Tyr Trp Ala Cys Gly Val Val Leu Ile Ile 
            420                 425                 430         


Ser Gly Ile Tyr Leu Phe Ile Gly Met Gly Ile Asn Tyr Arg Leu Leu 
        435                 440                 445             


Ala Lys Glu Gln Lys Ala Asn Glu Gln Lys Lys Glu Ser Lys Glu Glu 
    450                 455                 460                 


Glu Thr Ser Ile Asp Val Ala Gly Lys Pro Asn Glu Val Thr Lys Ala 
465                 470                 475                 480 


Ala Glu Ser Pro Asp Gln Lys Asp Thr Asp Gly Gly Pro Lys Glu Glu 
                485                 490                 495     


Glu Ser Pro Val 
            500 


<210>  2172
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  2172

Met Ser Gly Glu Ile Ala Met Cys Glu Pro Glu Phe Gly Asn Asp Lys 
1               5                   10                  15      


Ala Arg Glu Pro Ser Val Gly Gly Arg Trp Arg Val Ser Trp Tyr Glu 
            20                  25                  30          


Arg Phe Val Gln Pro Cys Leu Val Glu Leu Leu Gly Ser Ala Leu Phe 
        35                  40                  45              


Ile Phe Ile Gly Cys Leu Ser Val Ile Glu Asn Gly Thr Asp Thr Gly 
    50                  55                  60                  


Leu Leu Gln Pro Ala Leu Ala His Gly Leu Ala Leu Gly Leu Val Ile 
65                  70                  75                  80  


Ala Thr Leu Gly Asn Ile Ser Gly Gly His Phe Asn Pro Ala Val Ser 
                85                  90                  95      


Leu Ala Ala Met Leu Ile Gly Gly Leu Asn Leu Val Met Leu Leu Pro 
            100                 105                 110         


Tyr Trp Val Ser Gln Leu Leu Gly Gly Met Leu Gly Ala Ala Leu Ala 
        115                 120                 125             


Lys Ala Val Ser Pro Glu Glu Arg Phe Trp Asn Ala Ser Gly Ala Ala 
    130                 135                 140                 


Phe Val Thr Val Gln Glu Gln Gly Gln Val Ala Gly Ala Leu Val Ala 
145                 150                 155                 160 


Glu Ile Ile Leu Thr Thr Leu Leu Ala Leu Ala Val Cys Met Gly Ala 
                165                 170                 175     


Ile Asn Glu Lys Thr Lys Gly Pro Leu Ala Pro Phe Ser Ile Gly Phe 
            180                 185                 190         


Ala Val Thr Val Asp Ile Leu Ala Gly Gly Pro Val Ser Gly Gly Cys 
        195                 200                 205             


Met Asn Pro Ala Arg Ala Phe Gly Pro Ala Val Val Ala Asn His Trp 
    210                 215                 220                 


Asn Phe His Trp Ile Tyr Trp Leu Gly Pro Leu Leu Ala Gly Leu Leu 
225                 230                 235                 240 


Val Gly Leu Leu Ile Arg Cys Phe Ile Gly Asp Gly Lys Thr Arg Leu 
                245                 250                 255     


Ile Leu Lys Ala Arg 
            260     


<210>  2173
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  2173

Met Leu Ser Arg Asn Asp Val Lys Arg Leu Glu Arg Ser Trp His Leu 
1               5                   10                  15      


Leu Ser Trp Ser Gln Ala Gln Gly Ser Ser Glu Gln Glu Leu His Tyr 
            20                  25                  30          


Ala Ser Leu Gln Arg Leu Pro Val Pro Ser Ser Glu Gly Pro Asp Leu 
        35                  40                  45              


Arg Gly Arg Asp Lys Arg Gly Thr Lys Glu Asp Pro Arg Ala Asp Tyr 
    50                  55                  60                  


Ala Cys Ile Ala Glu Asn Lys Pro Thr 
65                  70              


<210>  2174
<211>  808
<212>  PRT
<213>  Homo sapiens

<400>  2174

Met Trp Leu Arg Leu Gly Pro Pro Ser Leu Ser Leu Ser Pro Lys Pro 
1               5                   10                  15      


Thr Val Gly Arg Ser Leu Cys Leu Thr Leu Trp Phe Leu Ser Leu Ala 
            20                  25                  30          


Leu Arg Ala Ser Thr Gln Ala Pro Ala Pro Thr Val Asn Thr His Phe 
        35                  40                  45              


Gly Lys Leu Arg Gly Ala Arg Val Pro Leu Pro Ser Glu Ile Leu Gly 
    50                  55                  60                  


Pro Val Asp Gln Tyr Leu Gly Val Pro Tyr Ala Ala Pro Pro Ile Gly 
65                  70                  75                  80  


Glu Lys Arg Phe Leu Pro Pro Glu Pro Pro Pro Ser Trp Ser Gly Ile 
                85                  90                  95      


Arg Asn Ala Thr His Phe Pro Pro Val Cys Pro Gln Asn Ile His Thr 
            100                 105                 110         


Ala Val Pro Glu Val Met Leu Pro Val Trp Phe Thr Ala Asn Leu Asp 
        115                 120                 125             


Ile Val Ala Thr Tyr Ile Gln Glu Pro Asn Glu Asp Cys Leu Tyr Leu 
    130                 135                 140                 


Asn Val Tyr Val Pro Thr Glu Asp Asp Ile Arg Asp Ser Gly Ala Lys 
145                 150                 155                 160 


Pro Val Met Val Tyr Ile His Gly Gly Ser Tyr Met Glu Gly Thr Gly 
                165                 170                 175     


Asn Met Ile Asp Gly Ser Ile Leu Ala Ser Tyr Gly Asn Val Ile Val 
            180                 185                 190         


Ile Thr Leu Asn Tyr Arg Val Gly Val Leu Gly Phe Leu Ser Thr Gly 
        195                 200                 205             


Asp Gln Ala Ala Lys Gly Asn Tyr Gly Leu Leu Asp Gln Ile Gln Ala 
    210                 215                 220                 


Leu Arg Trp Val Ser Glu Asn Ile Ala Phe Phe Gly Gly Asp Pro Arg 
225                 230                 235                 240 


Arg Ile Thr Val Phe Gly Ser Gly Ile Gly Ala Ser Cys Val Ser Leu 
                245                 250                 255     


Leu Thr Leu Ser His His Ser Glu Gly Leu Phe Gln Arg Ala Ile Ile 
            260                 265                 270         


Gln Ser Gly Ser Ala Leu Ser Ser Trp Ala Val Asn Tyr Gln Pro Val 
        275                 280                 285             


Lys Tyr Thr Ser Leu Leu Ala Asp Lys Val Gly Cys Asn Val Leu Asp 
    290                 295                 300                 


Thr Val Asp Met Val Asp Cys Leu Arg Gln Lys Ser Ala Lys Glu Leu 
305                 310                 315                 320 


Val Glu Gln Asp Ile Gln Pro Ala Arg Tyr His Val Ala Phe Gly Pro 
                325                 330                 335     


Val Ile Asp Gly Asp Val Ile Pro Asp Asp Pro Glu Ile Leu Met Glu 
            340                 345                 350         


Gln Gly Glu Phe Leu Asn Tyr Asp Ile Met Leu Gly Val Asn Gln Gly 
        355                 360                 365             


Glu Gly Leu Lys Phe Val Glu Gly Val Val Asp Pro Glu Asp Gly Val 
    370                 375                 380                 


Ser Gly Thr Asp Phe Asp Tyr Ser Val Ser Asn Phe Val Asp Asn Leu 
385                 390                 395                 400 


Tyr Gly Tyr Pro Glu Gly Lys Asp Thr Leu Arg Glu Thr Ile Lys Phe 
                405                 410                 415     


Met Tyr Thr Asp Trp Ala Asp Arg Asp Asn Pro Glu Thr Arg Arg Lys 
            420                 425                 430         


Thr Leu Val Ala Leu Phe Thr Asp His Gln Trp Val Glu Pro Ser Val 
        435                 440                 445             


Val Thr Ala Asp Leu His Ala Arg Tyr Gly Ser Pro Thr Tyr Phe Tyr 
    450                 455                 460                 


Ala Phe Tyr His His Cys Gln Ser Leu Met Lys Pro Ala Trp Ser Asp 
465                 470                 475                 480 


Ala Ala His Gly Asp Glu Val Pro Tyr Val Phe Gly Val Pro Met Val 
                485                 490                 495     


Gly Pro Thr Asp Leu Phe Pro Cys Asn Phe Ser Lys Asn Asp Val Met 
            500                 505                 510         


Leu Ser Ala Val Val Met Thr Tyr Trp Thr Asn Phe Ala Lys Thr Gly 
        515                 520                 525             


Asp Pro Asn Lys Pro Val Pro Gln Asp Thr Lys Phe Ile His Thr Lys 
    530                 535                 540                 


Ala Asn Arg Phe Glu Glu Val Ala Trp Ser Lys Tyr Asn Pro Arg Asp 
545                 550                 555                 560 


Gln Leu Tyr Leu His Ile Gly Leu Lys Pro Arg Val Arg Asp His Tyr 
                565                 570                 575     


Arg Ala Thr Lys Val Ala Phe Trp Lys His Leu Val Pro His Leu Tyr 
            580                 585                 590         


Asn Leu His Asp Met Phe His Tyr Thr Ser Thr Thr Thr Lys Val Pro 
        595                 600                 605             


Pro Pro Asp Thr Thr His Ser Ser His Ile Thr Arg Arg Pro Asn Gly 
    610                 615                 620                 


Lys Thr Trp Ser Thr Lys Arg Pro Ala Ile Ser Pro Ala Tyr Ser Asn 
625                 630                 635                 640 


Glu Asn Ala Gln Gly Ser Trp Asn Gly Asp Gln Asp Ala Gly Pro Leu 
                645                 650                 655     


Leu Val Glu Asn Pro Arg Asp Tyr Ser Thr Glu Leu Ser Val Thr Ile 
            660                 665                 670         


Ala Val Gly Ala Ser Leu Leu Phe Leu Asn Val Leu Ala Phe Ala Ala 
        675                 680                 685             


Leu Tyr Tyr Arg Lys Asp Lys Arg Arg Gln Glu Pro Leu Arg Gln Pro 
    690                 695                 700                 


Ser Pro Gln Arg Gly Ala Gly Ala Pro Glu Leu Gly Ala Ala Pro Glu 
705                 710                 715                 720 


Glu Glu Leu Ala Ala Leu Gln Leu Gly Pro Thr His His Glu Cys Glu 
                725                 730                 735     


Ala Gly Pro Pro His Asp Thr Leu Arg Leu Thr Ala Leu Pro Asp Tyr 
            740                 745                 750         


Thr Leu Thr Leu Arg Arg Ser Pro Asp Asp Ile Pro Leu Met Thr Pro 
        755                 760                 765             


Asn Thr Ile Thr Met Ile Pro Asn Ser Leu Val Gly Leu Gln Thr Leu 
    770                 775                 780                 


His Pro Tyr Asn Thr Phe Ala Ala Gly Phe Asn Ser Thr Gly Leu Pro 
785                 790                 795                 800 


His Ser His Ser Thr Thr Arg Val 
                805             


<210>  2175
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  2175

Met Leu Gly Gln Val Val Thr Leu Ile Leu Leu Leu Leu Leu Lys Val 
1               5                   10                  15      


Tyr Gln Gly Lys Gly Cys Gln Gly Ser Ala Asp His Val Val Ser Ile 
            20                  25                  30          


Ser Gly Val Pro Leu Gln Leu Gln Pro Asn Ser Ile Gln Thr Lys Val 
        35                  40                  45              


Asp Ser Ile Ala Trp Lys Lys Leu Leu Pro Ser Gln Asn Gly Phe His 
    50                  55                  60                  


His Ile Leu Lys Trp Glu Asn Gly Ser Leu Pro Ser Asn Thr Ser Asn 
65                  70                  75                  80  


Asp Arg Phe Ser Phe Ile Val Lys Asn Leu Ser Leu Leu Ile Lys Ala 
                85                  90                  95      


Ala Gln Gln Gln Asp Ser Gly Leu Tyr Cys Leu Glu Val Thr Ser Ile 
            100                 105                 110         


Ser Gly Lys Val Gln Thr Ala Thr Phe Gln Val Phe Val Phe Glu Ser 
        115                 120                 125             


Leu Leu Pro Asp Lys Val Glu Lys Pro Arg Leu Gln Gly Gln Gly Lys 
    130                 135                 140                 


Ile Leu Asp Arg Gly Arg Cys Gln Val Ala Leu Ser Cys Leu Val Ser 
145                 150                 155                 160 


Arg Asp Gly Asn Val Ser Tyr Ala Trp Tyr Arg Gly Ser Lys Leu Ile 
                165                 170                 175     


Gln Thr Ala Gly Asn Leu Thr Tyr Leu Asp Glu Glu Val Asp Ile Asn 
            180                 185                 190         


Gly Thr His Thr Tyr Thr Cys Asn Val Ser Asn Pro Val Ser Trp Glu 
        195                 200                 205             


Ser His Thr Leu Asn Leu Thr Gln Asp Cys Gln Asn Ala His Gln Glu 
    210                 215                 220                 


Phe Arg Phe Trp Pro Phe Leu Val Ile Ile Val Ile Leu Ser Ala Leu 
225                 230                 235                 240 


Phe Leu Gly Thr Leu Ala Cys Phe Cys Val Trp Arg Arg Lys Arg Lys 
                245                 250                 255     


Glu Lys Gln Ser Glu Thr Ser Pro Lys Glu Phe Leu Thr Ile Tyr Glu 
            260                 265                 270         


Asp Val Lys Asp Leu Lys Thr Arg Arg Asn His Glu Gln Glu Gln Thr 
        275                 280                 285             


Phe Pro Gly Gly Gly Ser Thr Ile Tyr Ser Met Ile Gln Ser Gln Ser 
    290                 295                 300                 


Ser Ala Pro Thr Ser Gln Glu Pro Ala Tyr Thr Leu Tyr Ser Leu Ile 
305                 310                 315                 320 


Gln Pro Ser Arg Lys Ser Gly Ser Arg Lys Arg Asn His Ser Pro Ser 
                325                 330                 335     


Phe Asn Ser Thr Ile Tyr Glu Val Ile Gly Lys Ser Gln Pro Lys Ala 
            340                 345                 350         


Gln Asn Pro Ala Arg Leu Ser Arg Lys Glu Leu Glu Asn Phe Asp Val 
        355                 360                 365             


Tyr Ser 
    370 


<210>  2176
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  2176

Met Leu Gly Gln Val Val Thr Leu Ile Leu Leu Leu Leu Leu Lys Val 
1               5                   10                  15      


Tyr Gln Gly Lys Gly Cys Gln Gly Ser Ala Asp His Val Val Ser Ile 
            20                  25                  30          


Ser Gly Val Pro Leu Gln Leu Gln Pro Asn Ser Ile Gln Thr Lys Val 
        35                  40                  45              


Asp Ser Ile Ala Trp Lys Lys Leu Leu Pro Ser Gln Asn Gly Phe His 
    50                  55                  60                  


His Ile Leu Lys Trp Glu Asn Gly Ser Leu Pro Ser Asn Thr Ser Asn 
65                  70                  75                  80  


Asp Arg Phe Ser Phe Ile Val Lys Asn Leu Ser Leu Leu Ile Lys Ala 
                85                  90                  95      


Ala Gln Gln Gln Asp Ser Gly Leu Tyr Cys Leu Glu Val Thr Ser Ile 
            100                 105                 110         


Ser Gly Lys Val Gln Thr Ala Thr Phe Gln Val Phe Val Phe Glu Phe 
        115                 120                 125             


Arg Phe Trp Pro Phe Leu Val Ile Ile Val Ile Leu Ser Ala Leu Phe 
    130                 135                 140                 


Leu Gly Thr Leu Ala Cys Phe Cys Val Trp Arg Arg Lys Arg Lys Glu 
145                 150                 155                 160 


Lys Gln Ser Glu Thr Ser Pro Lys Glu Phe Leu Thr Ile Tyr Glu Asp 
                165                 170                 175     


Val Lys Asp Leu Lys Thr Arg Arg Asn His Glu Gln Glu Gln Thr Phe 
            180                 185                 190         


Pro Gly Gly Gly Ser Thr Ile Tyr Ser Met Ile Gln Ser Gln Ser Ser 
        195                 200                 205             


Ala Pro Thr Ser Gln Glu Pro Ala Tyr Thr Leu Tyr Ser Leu Ile Gln 
    210                 215                 220                 


Pro Ser Arg Lys Ser Gly Ser Arg Lys Arg Asn His Ser Pro Ser Phe 
225                 230                 235                 240 


Asn Ser Thr Ile Tyr Glu Val Ile Gly Lys Ser Gln Pro Lys Ala Gln 
                245                 250                 255     


Asn Pro Ala Arg Leu Ser Arg Lys Glu Leu Glu Asn Phe Asp Val Tyr 
            260                 265                 270         


Ser 
    


<210>  2177
<211>  489
<212>  PRT
<213>  Homo sapiens

<400>  2177

Met Gly Ser Gly Pro Leu Ser Leu Pro Leu Ala Leu Ser Pro Pro Arg 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Ser Leu Leu Pro Val Ala Arg Ala Ser 
            20                  25                  30          


Glu Ala Glu His Arg Leu Phe Glu Arg Leu Phe Glu Asp Tyr Asn Glu 
        35                  40                  45              


Ile Ile Arg Pro Val Ala Asn Val Ser Asp Pro Val Ile Ile His Phe 
    50                  55                  60                  


Glu Val Ser Met Ser Gln Leu Val Lys Val Asp Glu Val Asn Gln Ile 
65                  70                  75                  80  


Met Glu Thr Asn Leu Trp Leu Lys Gln Ile Trp Asn Asp Tyr Lys Leu 
                85                  90                  95      


Lys Trp Asn Pro Ser Asp Tyr Gly Gly Ala Glu Phe Met Arg Val Pro 
            100                 105                 110         


Ala Gln Lys Ile Trp Lys Pro Asp Ile Val Leu Tyr Asn Asn Ala Val 
        115                 120                 125             


Gly Asp Phe Gln Val Asp Asp Lys Thr Lys Ala Leu Leu Lys Tyr Thr 
    130                 135                 140                 


Gly Glu Val Thr Trp Ile Pro Pro Ala Ile Phe Lys Ser Ser Cys Lys 
145                 150                 155                 160 


Ile Asp Val Thr Tyr Phe Pro Phe Asp Tyr Gln Asn Cys Thr Met Lys 
                165                 170                 175     


Phe Gly Ser Trp Ser Tyr Asp Lys Ala Lys Ile Asp Leu Val Leu Ile 
            180                 185                 190         


Gly Ser Ser Met Asn Leu Lys Asp Tyr Trp Glu Ser Gly Glu Trp Ala 
        195                 200                 205             


Ile Ile Lys Ala Pro Gly Tyr Lys His Asp Ile Lys Tyr Asn Cys Cys 
    210                 215                 220                 


Glu Glu Ile Tyr Pro Asp Ile Thr Tyr Ser Leu Tyr Ile Arg Arg Leu 
225                 230                 235                 240 


Pro Leu Phe Tyr Thr Ile Asn Leu Ile Ile Pro Cys Leu Leu Ile Ser 
                245                 250                 255     


Phe Leu Thr Val Leu Val Phe Tyr Leu Pro Ser Asp Cys Gly Glu Lys 
            260                 265                 270         


Val Thr Leu Cys Ile Ser Val Leu Leu Ser Leu Thr Val Phe Leu Leu 
        275                 280                 285             


Val Ile Thr Glu Thr Ile Pro Ser Thr Ser Leu Val Ile Pro Leu Ile 
    290                 295                 300                 


Gly Glu Tyr Leu Leu Phe Thr Met Ile Phe Val Thr Leu Ser Ile Val 
305                 310                 315                 320 


Ile Thr Val Phe Val Leu Asn Val His Tyr Arg Thr Pro Thr Thr His 
                325                 330                 335     


Thr Met Pro Ser Trp Val Lys Thr Val Phe Leu Asn Leu Leu Pro Arg 
            340                 345                 350         


Val Met Phe Met Thr Arg Pro Thr Ser Asn Glu Gly Asn Ala Gln Lys 
        355                 360                 365             


Pro Arg Pro Leu Tyr Gly Ala Glu Leu Ser Asn Leu Asn Cys Phe Ser 
    370                 375                 380                 


Arg Ala Glu Ser Lys Gly Cys Lys Glu Gly Tyr Pro Cys Gln Asp Gly 
385                 390                 395                 400 


Met Cys Gly Tyr Cys His His Arg Arg Ile Lys Ile Ser Asn Phe Ser 
                405                 410                 415     


Ala Asn Leu Thr Arg Ser Ser Ser Ser Glu Ser Val Asp Ala Val Leu 
            420                 425                 430         


Ser Leu Ser Ala Leu Ser Pro Glu Ile Lys Glu Ala Ile Gln Ser Val 
        435                 440                 445             


Lys Tyr Ile Ala Glu Asn Met Lys Ala Gln Asn Glu Ala Lys Glu Glu 
    450                 455                 460                 


Gln Lys Ala Gln Glu Ile Gln Gln Leu Lys Arg Lys Glu Lys Ser Thr 
465                 470                 475                 480 


Glu Thr Ser Asp Gln Glu Pro Gly Leu 
                485                 


<210>  2178
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  2178

Met Thr Lys Ser Asn Gly Glu Glu Pro Lys Met Gly Gly Arg Met Glu 
1               5                   10                  15      


Arg Phe Gln Gln Gly Val Arg Lys Arg Thr Leu Leu Ala Lys Lys Lys 
            20                  25                  30          


Val Gln Asn Ile Thr Lys Glu Asp Val Lys Ser Tyr Leu Phe Arg Asn 
        35                  40                  45              


Ala Phe Val Leu Leu Thr Val Thr Ala Val Ile Val Gly Thr Ile Leu 
    50                  55                  60                  


Gly Phe Thr Leu Arg Pro Tyr Arg Met Ser Tyr Arg Glu Val Lys Tyr 
65                  70                  75                  80  


Phe Ser Phe Pro Gly Glu Leu Leu Met Arg Met Leu Gln Met Leu Val 
                85                  90                  95      


Leu Pro Leu Ile Ile Ser Ser Leu Val Thr Gly Met Ala Ala Leu Asp 
            100                 105                 110         


Ser Lys Ala Ser Gly Lys Met Gly Met Arg Ala Val Val Tyr Tyr Met 
        115                 120                 125             


Thr Thr Thr Ile Ile Ala Val Val Ile Gly Ile Ile Ile Val Ile Ile 
    130                 135                 140                 


Ile His Pro Gly Lys Gly Thr Lys Glu Asn Met His Arg Glu Gly Lys 
145                 150                 155                 160 


Ile Val Arg Val Thr Ala Ala Asp Ala Phe Leu Asp Leu Ile Arg Asn 
                165                 170                 175     


Met Phe Pro Pro Asn Leu Val Glu Ala Cys Phe Lys Gln Phe Lys Thr 
            180                 185                 190         


Asn Tyr Glu Lys Arg Ser Phe Lys Val Pro Ile Gln Ala Asn Glu Thr 
        195                 200                 205             


Leu Val Gly Ala Val Ile Asn Asn Val Ser Glu Ala Met Glu Thr Leu 
    210                 215                 220                 


Thr Arg Ile Thr Glu Glu Leu Val Pro Val Pro Gly Ser Val Asn Gly 
225                 230                 235                 240 


Val Asn Ala Leu Gly Leu Val Val Phe Ser Met Cys Phe Gly Phe Val 
                245                 250                 255     


Ile Gly Asn Met Lys Glu Gln Gly Gln Ala Leu Arg Glu Phe Phe Asp 
            260                 265                 270         


Ser Leu Asn Glu Ala Ile Met Arg Leu Val Ala Val Ile Met Trp Tyr 
        275                 280                 285             


Ala Pro Val Gly Ile Leu Phe Leu Ile Ala Gly Lys Ile Val Glu Met 
    290                 295                 300                 


Glu Asp Met Gly Val Ile Gly Gly Gln Leu Ala Met Tyr Thr Val Thr 
305                 310                 315                 320 


Val Ile Val Gly Leu Leu Ile His Ala Val Ile Val Leu Pro Leu Leu 
                325                 330                 335     


Tyr Phe Leu Val Thr Arg Lys Asn Pro Trp Val Phe Ile Gly Gly Leu 
            340                 345                 350         


Leu Gln Ala Leu Ile Thr Ala Leu Gly Thr Ser Ser Ser Ser Ala Thr 
        355                 360                 365             


Leu Pro Ile Thr Phe Lys Cys Leu Glu Glu Asn Asn Gly Val Asp Lys 
    370                 375                 380                 


Arg Val Thr Arg Phe Val Leu Pro Val Gly Ala Thr Ile Asn Met Asp 
385                 390                 395                 400 


Gly Thr Ala Leu Tyr Glu Ala Leu Ala Ala Ile Phe Ile Ala Gln Val 
                405                 410                 415     


Asn Asn Phe Glu Leu Asn Phe Gly Gln Ile Ile Thr Ile Arg Asp Arg 
            420                 425                 430         


Leu Arg Thr Thr Thr Asn Val Leu Gly Asp Ser Leu Gly Ala Gly Ile 
        435                 440                 445             


Val Glu His Leu Ser Arg His Glu Leu Lys Asn Arg Asp Val Glu Met 
    450                 455                 460                 


Gly Asn Ser Val Ile Glu Glu Asn Glu Met Lys Lys Pro Tyr Gln Leu 
465                 470                 475                 480 


Ile Ala Gln Asp Asn Glu Thr Glu Lys Pro Ile Asp Ser Glu Thr Lys 
                485                 490                 495     


Met 
    


<210>  2179
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  2179

Met Thr Lys Ser Asn Gly Glu Glu Pro Lys Met Gly Gly Arg Met Glu 
1               5                   10                  15      


Arg Phe Gln Gln Gly Val Arg Lys Arg Thr Leu Leu Ala Lys Lys Lys 
            20                  25                  30          


Val Gln Asn Ile Thr Lys Glu Asp Val Lys Ser Tyr Leu Phe Arg Asn 
        35                  40                  45              


Ala Phe Val Leu Leu Thr Val Thr Ala Val Ile Val Gly Glu Ser Phe 
    50                  55                  60                  


Asp 
65  


<210>  2180
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  2180

Met Val Gln Ala Ser Gly His Arg Arg Ser Thr Arg Gly Ser Lys Met 
1               5                   10                  15      


Val Ser Trp Ser Val Ile Ala Lys Ile Gln Glu Ile Leu Gln Arg Lys 
            20                  25                  30          


Met Val Arg Glu Phe Leu Ala Glu Phe Met Ser Thr Tyr Val Met Met 
        35                  40                  45              


Val Phe Gly Leu Gly Ser Val Ala His Met Val Leu Asn Lys Lys Tyr 
    50                  55                  60                  


Gly Ser Tyr Leu Gly Val Asn Leu Gly Phe Gly Phe Gly Val Thr Met 
65                  70                  75                  80  


Gly Val His Val Ala Gly Arg Ile Ser Gly Ala His Met Asn Ala Ala 
                85                  90                  95      


Val Thr Phe Ala Asn Cys Ala Leu Gly Arg Val Pro Trp Arg Lys Phe 
            100                 105                 110         


Pro Val Tyr Val Leu Gly Gln Phe Leu Gly Ser Phe Leu Ala Ala Ala 
        115                 120                 125             


Thr Ile Tyr Ser Leu Phe Tyr Thr Ala Ile Leu His Phe Ser Gly Gly 
    130                 135                 140                 


Gln Leu Met Val Thr Gly Pro Val Ala Thr Ala Gly Ile Phe Ala Thr 
145                 150                 155                 160 


Tyr Leu Pro Asp His Met Thr Leu Trp Arg Gly Phe Leu Asn Glu Ala 
                165                 170                 175     


Trp Leu Thr Gly Met Leu Gln Leu Cys Leu Phe Ala Ile Thr Asp Gln 
            180                 185                 190         


Glu Asn Asn Pro Ala Leu Pro Gly Thr Glu Ala Leu Val Ile Gly Ile 
        195                 200                 205             


Leu Val Val Ile Ile Gly Val Ser Leu Gly Met Asn Thr Gly Tyr Ala 
    210                 215                 220                 


Ile Asn Pro Ser Arg Asp Leu Pro Pro Arg Ile Phe Thr Phe Ile Ala 
225                 230                 235                 240 


Gly Trp Gly Lys Gln Val Phe Ser Asn Gly Glu Asn Trp Trp Trp Val 
                245                 250                 255     


Pro Val Val Ala Pro Leu Leu Gly Ala Tyr Leu Gly Gly Ile Ile Tyr 
            260                 265                 270         


Leu Val Phe Ile Gly Ser Thr Ile Pro Arg Glu Pro Leu Lys Leu Glu 
        275                 280                 285             


Asp Ser Val Ala Tyr Glu Asp His Gly Ile Thr Val Leu Pro Lys Met 
    290                 295                 300                 


Gly Ser His Glu Pro Thr Ile Ser Pro Leu Thr Pro Val Ser Val Ser 
305                 310                 315                 320 


Pro Ala Asn Arg Ser Ser Val His Pro Ala Pro Pro Leu His Glu Ser 
                325                 330                 335     


Met Ala Leu Glu His Phe 
            340         


<210>  2181
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  2181

Met Pro Pro Leu Trp Ala Leu Leu Ala Leu Gly Cys Leu Arg Phe Gly 
1               5                   10                  15      


Ser Ala Val Asn Leu Gln Pro Gln Leu Ala Ser Val Thr Phe Ala Thr 
            20                  25                  30          


Asn Asn Pro Thr Leu Thr Thr Val Ala Leu Glu Lys Pro Leu Cys Met 
        35                  40                  45              


Phe Asp Ser Lys Glu Ala Leu Thr Gly Thr His Glu Val Tyr Leu Tyr 
    50                  55                  60                  


Val Leu Val Asp Ser Val Thr Pro Tyr Ser Thr Ile Asp Thr Trp Pro 
65                  70                  75                  80  


Gly Arg Arg Ser Gly Gly Met Ile Val Ile Thr Ser Ile Leu Gly Ser 
                85                  90                  95      


Leu Pro Phe Phe Leu Leu Val Gly Phe Ala Gly Ala Ile Ala Leu Ser 
            100                 105                 110         


Leu Val Asp Met Gly Ser Ser Asp Gly Glu Thr Thr His Asp Ser Gln 
        115                 120                 125             


Ile Thr Gln Glu Ala Val Pro Lys Ser Leu Gly Ala Ser Glu Ser Ser 
    130                 135                 140                 


Tyr Thr Ser Val Asn Arg Gly Pro Pro Leu Asp Arg Ala Glu Val Tyr 
145                 150                 155                 160 


Ser Ser Lys Leu Gln Asp 
                165     


<210>  2182
<211>  746
<212>  PRT
<213>  Homo sapiens

<400>  2182

Met Leu Arg Asn Ser Thr Phe Lys Asn Met Gln Arg Arg His Thr Thr 
1               5                   10                  15      


Leu Arg Glu Lys Gly Arg Arg Gln Ala Ile Arg Gly Pro Ala Tyr Met 
            20                  25                  30          


Phe Asn Glu Lys Gly Thr Ser Leu Thr Pro Glu Glu Glu Arg Phe Leu 
        35                  40                  45              


Asp Ser Ala Glu Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu Glu 
    50                  55                  60                  


Glu Ser Lys Thr Leu Asn Phe Asn Cys Val Asp Tyr Met Gly Gln Asn 
65                  70                  75                  80  


Ala Leu Gln Leu Ala Val Gly Asn Glu His Leu Glu Val Thr Glu Leu 
                85                  90                  95      


Leu Leu Lys Lys Glu Asn Leu Ala Arg Val Gly Asp Ala Leu Leu Leu 
            100                 105                 110         


Ala Ile Ser Lys Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Asn His 
        115                 120                 125             


Pro Ala Phe Ala Gln Gly Gln Arg Leu Thr Leu Ser Pro Leu Glu Gln 
    130                 135                 140                 


Glu Leu Arg Asp Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr Arg 
145                 150                 155                 160 


Phe Ser His Asp Ile Thr Pro Ile Ile Leu Ala Ala His Cys Gln Glu 
                165                 170                 175     


Tyr Glu Ile Val His Ile Leu Leu Leu Lys Gly Ala Arg Ile Glu Arg 
            180                 185                 190         


Pro His Asp Tyr Phe Cys Lys Cys Asn Glu Cys Thr Glu Lys Gln Arg 
        195                 200                 205             


Lys Asp Ser Phe Ser His Ser Arg Ser Arg Met Asn Ala Tyr Lys Gly 
    210                 215                 220                 


Leu Ala Ser Ala Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val Leu 
225                 230                 235                 240 


Thr Ala Leu Glu Leu Ser Asn Glu Leu Ala Arg Leu Ala Asn Ile Glu 
                245                 250                 255     


Thr Glu Phe Lys Leu Gly Arg Thr Leu Arg Ser Pro Phe Met Lys Phe 
            260                 265                 270         


Val Ala His Ala Val Ser Phe Thr Ile Phe Leu Gly Leu Leu Val Val 
        275                 280                 285             


Asn Ala Ser Asp Arg Phe Glu Gly Val Lys Thr Leu Pro Asn Glu Thr 
    290                 295                 300                 


Phe Thr Asp Tyr Pro Lys Gln Ile Phe Arg Val Lys Thr Thr Gln Phe 
305                 310                 315                 320 


Ser Trp Thr Glu Met Leu Ile Met Lys Trp Val Leu Gly Met Ile Trp 
                325                 330                 335     


Ser Glu Cys Lys Glu Ile Trp Glu Glu Gly Pro Arg Glu Tyr Val Leu 
            340                 345                 350         


His Leu Trp Asn Leu Leu Asp Phe Gly Met Leu Ser Ile Phe Val Ala 
        355                 360                 365             


Ser Phe Thr Ala Arg Phe Met Ala Phe Leu Lys Ala Thr Glu Ala Gln 
    370                 375                 380                 


Leu Tyr Val Asp Gln His Val Gln Asp Asp Thr Leu His Asn Val Ser 
385                 390                 395                 400 


Leu Pro Pro Glu Val Ala Tyr Phe Thr Tyr Ala Arg Asp Lys Trp Trp 
                405                 410                 415     


Pro Ser Asp Pro Gln Ile Ile Ser Glu Gly Leu Tyr Ala Ile Ala Val 
            420                 425                 430         


Val Leu Ser Phe Ser Arg Ile Ala Tyr Ile Leu Pro Ala Asn Glu Ser 
        435                 440                 445             


Phe Gly Pro Leu Gln Ile Ser Leu Gly Arg Thr Val Lys Asp Ile Phe 
    450                 455                 460                 


Lys Phe Met Val Ile Phe Ile Met Val Phe Val Ala Phe Met Ile Gly 
465                 470                 475                 480 


Met Phe Asn Leu Tyr Ser Tyr Tyr Arg Gly Ala Lys Tyr Asn Pro Ala 
                485                 490                 495     


Phe Thr Thr Val Glu Glu Ser Phe Lys Thr Leu Phe Trp Ser Ile Phe 
            500                 505                 510         


Gly Leu Ser Glu Val Ile Ser Val Val Leu Lys Tyr Asp His Lys Phe 
        515                 520                 525             


Ile Glu Asn Ile Gly Tyr Val Leu Tyr Gly Val Tyr Asn Val Thr Met 
    530                 535                 540                 


Val Val Val Leu Leu Asn Met Leu Ile Ala Met Ile Asn Asn Ser Tyr 
545                 550                 555                 560 


Gln Glu Ile Glu Glu Asp Ala Asp Val Glu Trp Lys Phe Ala Arg Ala 
                565                 570                 575     


Lys Leu Trp Leu Ser Tyr Phe Asp Glu Gly Arg Thr Leu Pro Ala Pro 
            580                 585                 590         


Phe Asn Leu Val Pro Ser Pro Lys Ser Phe Tyr Tyr Leu Ile Met Arg 
        595                 600                 605             


Ile Lys Met Cys Leu Ile Lys Leu Cys Lys Ser Lys Ala Lys Ser Cys 
    610                 615                 620                 


Glu Asn Asp Leu Glu Met Gly Met Leu Asn Ser Lys Phe Lys Lys Thr 
625                 630                 635                 640 


Arg Tyr Gln Ala Gly Met Arg Asn Ser Glu Asn Leu Thr Ala Asn Asn 
                645                 650                 655     


Thr Leu Ser Lys Pro Thr Arg Tyr Gln Lys Ile Met Lys Arg Leu Ile 
            660                 665                 670         


Lys Arg Tyr Val Leu Lys Ala Gln Val Asp Arg Glu Asn Asp Glu Val 
        675                 680                 685             


Asn Glu Gly Glu Leu Lys Glu Ile Lys Gln Asp Ile Ser Ser Leu Arg 
    690                 695                 700                 


Tyr Glu Leu Leu Glu Glu Lys Ser Gln Ala Thr Gly Glu Leu Ala Asp 
705                 710                 715                 720 


Leu Ile Gln Gln Leu Ser Glu Lys Phe Gly Lys Asn Leu Asn Lys Asp 
                725                 730                 735     


His Leu Arg Val Asn Lys Gly Lys Asp Ile 
            740                 745     


<210>  2183
<211>  801
<212>  PRT
<213>  Homo sapiens

<400>  2183

Met Leu Arg Asn Ser Thr Phe Lys Asn Met Gln Arg Arg His Thr Thr 
1               5                   10                  15      


Leu Arg Glu Lys Gly Arg Arg Gln Ala Ile Arg Gly Pro Ala Tyr Met 
            20                  25                  30          


Phe Asn Glu Lys Gly Thr Ser Leu Thr Pro Glu Glu Glu Arg Phe Leu 
        35                  40                  45              


Asp Ser Ala Glu Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu Glu 
    50                  55                  60                  


Glu Ser Lys Thr Leu Asn Phe Asn Cys Val Asp Tyr Met Gly Gln Asn 
65                  70                  75                  80  


Ala Leu Gln Leu Ala Val Gly Asn Glu His Leu Glu Val Thr Glu Leu 
                85                  90                  95      


Leu Leu Lys Lys Glu Asn Leu Ala Arg Val Gly Asp Ala Leu Leu Leu 
            100                 105                 110         


Ala Ile Ser Lys Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Asn His 
        115                 120                 125             


Pro Ala Phe Ala Gln Gly Gln Arg Leu Thr Leu Ser Pro Leu Glu Gln 
    130                 135                 140                 


Glu Leu Arg Asp Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr Arg 
145                 150                 155                 160 


Phe Ser His Asp Ile Thr Pro Ile Ile Leu Ala Ala His Cys Gln Glu 
                165                 170                 175     


Tyr Glu Ile Val His Ile Leu Leu Leu Lys Gly Ala Arg Ile Glu Arg 
            180                 185                 190         


Pro His Asp Tyr Phe Cys Lys Cys Asn Glu Cys Thr Glu Lys Gln Arg 
        195                 200                 205             


Lys Asp Ser Phe Ser His Ser Arg Ser Arg Met Asn Ala Tyr Lys Gly 
    210                 215                 220                 


Leu Ala Ser Ala Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val Leu 
225                 230                 235                 240 


Thr Ala Leu Glu Leu Ser Asn Glu Leu Ala Arg Leu Ala Asn Ile Glu 
                245                 250                 255     


Thr Glu Phe Lys Phe Val Ala His Pro Asn Cys Gln Gln Gln Leu Leu 
            260                 265                 270         


Thr Met Trp Tyr Glu Asn Leu Ser Gly Leu Arg Gln Gln Ser Ile Ala 
        275                 280                 285             


Val Lys Phe Leu Ala Val Phe Gly Val Ser Ile Gly Leu Pro Phe Leu 
    290                 295                 300                 


Ala Ile Ala Tyr Trp Ile Ala Pro Cys Ser Lys Leu Gly Arg Thr Leu 
305                 310                 315                 320 


Arg Ser Pro Phe Met Lys Phe Val Ala His Ala Val Ser Phe Thr Ile 
                325                 330                 335     


Phe Leu Gly Leu Leu Val Val Asn Ala Ser Asp Arg Phe Glu Gly Val 
            340                 345                 350         


Lys Thr Leu Pro Asn Glu Thr Phe Thr Asp Tyr Pro Lys Gln Ile Phe 
        355                 360                 365             


Arg Val Lys Thr Thr Gln Phe Ser Trp Thr Glu Met Leu Ile Met Lys 
    370                 375                 380                 


Trp Val Leu Gly Met Ile Trp Ser Glu Cys Lys Glu Ile Trp Glu Glu 
385                 390                 395                 400 


Gly Pro Arg Glu Tyr Val Leu His Leu Trp Asn Leu Leu Asp Phe Gly 
                405                 410                 415     


Met Leu Ser Ile Phe Val Ala Ser Phe Thr Ala Arg Phe Met Ala Phe 
            420                 425                 430         


Leu Lys Ala Thr Glu Ala Gln Leu Tyr Val Asp Gln His Val Gln Asp 
        435                 440                 445             


Asp Thr Leu His Asn Val Ser Leu Pro Pro Glu Val Ala Tyr Phe Thr 
    450                 455                 460                 


Tyr Ala Arg Asp Lys Trp Trp Pro Ser Asp Pro Gln Ile Ile Ser Glu 
465                 470                 475                 480 


Gly Leu Tyr Ala Ile Ala Val Val Leu Ser Phe Ser Arg Ile Ala Tyr 
                485                 490                 495     


Ile Leu Pro Ala Asn Glu Ser Phe Gly Pro Leu Gln Ile Ser Leu Gly 
            500                 505                 510         


Arg Thr Val Lys Asp Ile Phe Lys Phe Met Val Ile Phe Ile Met Val 
        515                 520                 525             


Phe Val Ala Phe Met Ile Gly Met Phe Asn Leu Tyr Ser Tyr Tyr Arg 
    530                 535                 540                 


Gly Ala Lys Tyr Asn Pro Ala Phe Thr Thr Val Glu Glu Ser Phe Lys 
545                 550                 555                 560 


Thr Leu Phe Trp Ser Ile Phe Gly Leu Ser Glu Val Ile Ser Val Val 
                565                 570                 575     


Leu Lys Tyr Asp His Lys Phe Ile Glu Asn Ile Gly Tyr Val Leu Tyr 
            580                 585                 590         


Gly Val Tyr Asn Val Thr Met Val Val Val Leu Leu Asn Met Leu Ile 
        595                 600                 605             


Ala Met Ile Asn Asn Ser Tyr Gln Glu Ile Glu Glu Asp Ala Asp Val 
    610                 615                 620                 


Glu Trp Lys Phe Ala Arg Ala Lys Leu Trp Leu Ser Tyr Phe Asp Glu 
625                 630                 635                 640 


Gly Arg Thr Leu Pro Ala Pro Phe Asn Leu Val Pro Ser Pro Lys Ser 
                645                 650                 655     


Phe Tyr Tyr Leu Ile Met Arg Ile Lys Met Cys Leu Ile Lys Leu Cys 
            660                 665                 670         


Lys Ser Lys Ala Lys Ser Cys Glu Asn Asp Leu Glu Met Gly Met Leu 
        675                 680                 685             


Asn Ser Lys Phe Lys Lys Thr Arg Tyr Gln Ala Gly Met Arg Asn Ser 
    690                 695                 700                 


Glu Asn Leu Thr Ala Asn Asn Thr Leu Ser Lys Pro Thr Arg Tyr Gln 
705                 710                 715                 720 


Lys Ile Met Lys Arg Leu Ile Lys Arg Tyr Val Leu Lys Ala Gln Val 
                725                 730                 735     


Asp Arg Glu Asn Asp Glu Val Asn Glu Gly Glu Leu Lys Glu Ile Lys 
            740                 745                 750         


Gln Asp Ile Ser Ser Leu Arg Tyr Glu Leu Leu Glu Glu Lys Ser Gln 
        755                 760                 765             


Ala Thr Gly Glu Leu Ala Asp Leu Ile Gln Gln Leu Ser Glu Lys Phe 
    770                 775                 780                 


Gly Lys Asn Leu Asn Lys Asp His Leu Arg Val Asn Lys Gly Lys Asp 
785                 790                 795                 800 


Ile 
    


<210>  2184
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  2184

Met Leu Ser Tyr Gly Glu Arg Leu Gly Ser Pro Ala Val Ser Pro Leu 
1               5                   10                  15      


Pro Val Arg Gly Gly His Val Met Arg Gly Thr Ala Phe Ala Tyr Val 
            20                  25                  30          


Pro Ser Pro Gln Val Leu His Arg Ile Pro Gly Thr Ser Ala Tyr Ala 
        35                  40                  45              


Phe Pro Ser Leu Gly Pro Val Ala Leu Ala Glu His Thr Cys Pro Cys 
    50                  55                  60                  


Gly Glu Val Leu Glu Arg His Glu Pro Leu Pro Ala Lys Leu Ala Leu 
65                  70                  75                  80  


Glu Glu Glu Gln Lys Pro Glu Ser Arg Leu Val Pro Lys Leu Arg Gln 
                85                  90                  95      


Ala Gly Ala Met Leu Leu Lys Val Pro Leu Met Leu Thr Phe Leu Tyr 
            100                 105                 110         


Leu Phe Val Cys Ser Leu Asp Met Leu Ser Ser Ala Phe Gln Leu Ala 
        115                 120                 125             


Gly Gly Lys Val Ala Gly Asp Ile Phe Lys Asp Asn Ala Ile Leu Ser 
    130                 135                 140                 


Asn Pro Val Ala Gly Leu Val Val Gly Ile Leu Val Thr Val Leu Val 
145                 150                 155                 160 


Gln Ser Ser Ser Thr Ser Thr Ser Ile Ile Val Ser Met Val Ser Ser 
                165                 170                 175     


Gly Leu Leu Glu Val Ser Ser Ala Ile Pro Ile Ile Met Gly Ser Asn 
            180                 185                 190         


Ile Gly Thr Ser Val Thr Asn Thr Ile Val Ala Leu Met Gln Ala Gly 
        195                 200                 205             


Asp Arg Thr Asp Phe Arg Arg Ala Phe Ala Gly Ala Thr Val His Asp 
    210                 215                 220                 


Cys Phe Asn Trp Leu Ser Val Leu Val Leu Leu Pro Leu Glu Ala Ala 
225                 230                 235                 240 


Thr Gly Tyr Leu His His Ile Thr Arg Leu Val Val Ala Ser Phe Asn 
                245                 250                 255     


Ile His Gly Gly Arg Asp Ala Pro Asp Leu Leu Lys Ile Ile Thr Glu 
            260                 265                 270         


Pro Phe Thr Lys Leu Ile Ile Gln Leu Asp Glu Ser Val Ile Thr Ser 
        275                 280                 285             


Ile Ala Thr Gly Asp Glu Ser Leu Arg Asn His Ser Leu Ile Gln Ile 
    290                 295                 300                 


Trp Cys His Pro Asp Ser Leu Gln Gln Asn Leu Glu Gly Arg Glu Ile 
305                 310                 315                 320 


Thr His Phe Asp Leu Arg Lys Lys Gln Ala Met Glu Asp Ser Ser Val 
                325                 330                 335     


Pro His Cys Pro 
            340 


<210>  2185
<211>  532
<212>  PRT
<213>  Homo sapiens

<400>  2185

Met Ile Val Tyr Leu Gly Met Met Ala Gly Ala Phe Ile Leu Gly Gly 
1               5                   10                  15      


Leu Ala Asp Lys Leu Gly Arg Lys Arg Val Leu Ser Met Ser Leu Ala 
            20                  25                  30          


Val Asn Ala Ser Phe Ala Ser Leu Ser Ser Phe Val Gln Gly Tyr Gly 
        35                  40                  45              


Ala Phe Leu Phe Cys Arg Leu Ile Ser Gly Ile Gly Ile Gly Gly Ala 
    50                  55                  60                  


Leu Pro Ile Val Phe Ala Tyr Phe Ser Glu Phe Leu Ser Arg Glu Lys 
65                  70                  75                  80  


Arg Gly Glu His Leu Ser Trp Leu Gly Ile Phe Trp Met Thr Gly Gly 
                85                  90                  95      


Leu Tyr Ala Ser Ala Met Ala Trp Ser Ile Ile Pro His Tyr Gly Trp 
            100                 105                 110         


Gly Phe Ser Met Gly Thr Asn Tyr His Phe His Ser Trp Arg Val Phe 
        115                 120                 125             


Val Ile Val Cys Ala Leu Pro Cys Thr Val Ser Met Val Ala Leu Lys 
    130                 135                 140                 


Phe Met Pro Glu Ser Pro Arg Phe Leu Leu Glu Met Gly Lys His Asp 
145                 150                 155                 160 


Glu Ala Trp Met Ile Leu Lys Gln Val His Asp Thr Asn Met Arg Ala 
                165                 170                 175     


Lys Gly Thr Pro Glu Lys Val Phe Thr Val Ser Asn Ile Lys Thr Pro 
            180                 185                 190         


Lys Gln Met Asp Glu Phe Ile Glu Ile Gln Ser Ser Thr Gly Thr Trp 
        195                 200                 205             


Tyr Gln Arg Trp Leu Val Arg Phe Lys Thr Ile Phe Lys Gln Val Trp 
    210                 215                 220                 


Asp Asn Ala Leu Tyr Cys Val Met Gly Pro Tyr Arg Met Asn Thr Leu 
225                 230                 235                 240 


Ile Leu Ala Val Val Trp Phe Ala Met Ala Phe Ser Tyr Tyr Gly Leu 
                245                 250                 255     


Thr Val Trp Phe Pro Asp Met Ile Arg Tyr Phe Gln Asp Glu Glu Tyr 
            260                 265                 270         


Lys Ser Lys Met Lys Val Phe Phe Gly Glu His Val Tyr Gly Ala Thr 
        275                 280                 285             


Ile Asn Phe Thr Met Glu Asn Gln Ile His Gln His Gly Lys Leu Val 
    290                 295                 300                 


Asn Asp Lys Phe Thr Arg Met Tyr Phe Lys His Val Leu Phe Glu Asp 
305                 310                 315                 320 


Thr Phe Phe Asp Glu Cys Tyr Phe Glu Asp Val Thr Ser Thr Asp Thr 
                325                 330                 335     


Tyr Phe Lys Asn Cys Thr Ile Glu Ser Thr Ile Phe Tyr Asn Thr Asp 
            340                 345                 350         


Leu Tyr Glu His Lys Phe Ile Asn Cys Arg Phe Ile Asn Ser Thr Phe 
        355                 360                 365             


Leu Glu Gln Lys Glu Gly Cys His Met Asp Leu Glu Gln Asp Asn Asp 
    370                 375                 380                 


Phe Leu Ile Tyr Leu Val Ser Phe Leu Gly Ser Leu Ser Val Leu Pro 
385                 390                 395                 400 


Gly Asn Ile Ile Ser Ala Leu Leu Met Asp Arg Ile Gly Arg Leu Lys 
                405                 410                 415     


Met Ile Gly Gly Ser Met Leu Ile Ser Ala Val Cys Cys Phe Phe Leu 
            420                 425                 430         


Phe Phe Gly Asn Ser Glu Ser Ala Met Ile Gly Trp Gln Cys Leu Phe 
        435                 440                 445             


Cys Gly Thr Ser Ile Ala Ala Trp Asn Ala Leu Asp Val Ile Thr Val 
    450                 455                 460                 


Glu Leu Tyr Pro Thr Asn Gln Arg Ala Thr Ala Phe Gly Ile Leu Asn 
465                 470                 475                 480 


Gly Leu Cys Lys Phe Gly Ala Ile Leu Gly Asn Thr Ile Phe Ala Ser 
                485                 490                 495     


Phe Val Gly Ile Thr Lys Val Val Pro Ile Leu Leu Ala Ala Ala Ser 
            500                 505                 510         


Leu Val Gly Gly Gly Leu Ile Ala Leu Arg Leu Pro Glu Thr Arg Glu 
        515                 520                 525             


Gln Val Leu Met 
    530         


<210>  2186
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  2186

Met Thr Ser Ser Pro Arg Ala Pro Pro Gly Glu Gln Gly Arg Gly Gly 
1               5                   10                  15      


Ala Glu Met Ile Arg Ala Ala Pro Pro Pro Leu Phe Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Val Ser Trp Ala Ser Arg Gly Glu Ala Ala Pro 
        35                  40                  45              


Asp Gln Asp Glu Ile Gln Arg Leu Pro Gly Leu Ala Lys Gln Pro Ser 
    50                  55                  60                  


Phe Arg Gln Tyr Ser Gly Tyr Leu Lys Gly Ser Gly Ser Lys His Leu 
65                  70                  75                  80  


His Tyr Trp Phe Val Glu Ser Gln Lys Asp Pro Glu Asn Ser Pro Val 
                85                  90                  95      


Val Leu Trp Leu Asn Gly Gly Pro Gly Cys Ser Ser Leu Asp Gly Leu 
            100                 105                 110         


Leu Thr Glu His Gly Pro Phe Leu Ile Ala Asn Val Leu Tyr Leu Glu 
        115                 120                 125             


Ser Pro Ala Gly Val Gly Phe Ser Tyr Ser Asp Asp Lys Phe Tyr Ala 
    130                 135                 140                 


Thr Asn Asp Thr Glu Val Ala Gln Ser Asn Phe Glu Ala Leu Gln Asp 
145                 150                 155                 160 


Phe Phe Arg Leu Phe Pro Glu Tyr Lys Asn Asn Lys Leu Phe Leu Thr 
                165                 170                 175     


Gly Glu Ser Tyr Ala Gly Ile Tyr Ile Pro Thr Leu Ala Val Leu Val 
            180                 185                 190         


Met Gln Asp Pro Ser Met Asn Leu Gln Gly Leu Ala Val Gly Asn Gly 
        195                 200                 205             


Leu Ser Ser Tyr Glu Gln Asn Asp Asn Ser Leu Val Tyr Phe Ala Tyr 
    210                 215                 220                 


Tyr His Gly Leu Leu Gly Asn Arg Leu Trp Ser Ser Leu Gln Thr His 
225                 230                 235                 240 


Cys Cys Ser Gln Asn Lys Cys Asn Phe Tyr Asp Asn Lys Asp Leu Glu 
                245                 250                 255     


Cys Val Thr Asn Leu Gln Glu Val Ala Arg Ile Val Gly Asn Ser Gly 
            260                 265                 270         


Leu Asn Ile Tyr Asn Leu Tyr Ala Pro Cys Ala Gly Gly Val Pro Ser 
        275                 280                 285             


His Phe Arg Tyr Glu Lys Asp Thr Val Val Val Gln Asp Leu Gly Asn 
    290                 295                 300                 


Ile Phe Thr Arg Leu Pro Leu Lys Arg Met Trp His Gln Ala Leu Leu 
305                 310                 315                 320 


Arg Ser Gly Asp Lys Val Arg Met Asp Pro Pro Cys Thr Asn Thr Thr 
                325                 330                 335     


Ala Ala Ser Thr Tyr Leu Asn Asn Pro Tyr Val Arg Lys Ala Leu Asn 
            340                 345                 350         


Ile Pro Glu Gln Leu Pro Gln Trp Asp Met Cys Asn Phe Leu Val Asn 
        355                 360                 365             


Leu Gln Tyr Arg Arg Leu Tyr Arg Ser Met Asn Ser Gln Tyr Leu Lys 
    370                 375                 380                 


Leu Leu Ser Ser Gln Lys Tyr Gln Ile Leu Leu Tyr Asn Gly Asp Val 
385                 390                 395                 400 


Asp Met Ala Cys Asn Phe Met Gly Asp Glu Trp Phe Val Asp Ser Leu 
                405                 410                 415     


Asn Gln Lys Met Glu Val Gln Arg Arg Pro Trp Leu Val Lys Tyr Gly 
            420                 425                 430         


Asp Ser Gly Glu Gln Ile Ala Gly Phe Val Lys Glu Phe Ser His Ile 
        435                 440                 445             


Ala Phe Leu Thr Ile Lys Gly Ala Gly His Met Val Pro Thr Asp Lys 
    450                 455                 460                 


Pro Leu Ala Ala Phe Thr Met Phe Ser Arg Phe Leu Asn Lys Gln Pro 
465                 470                 475                 480 


Tyr 
    


<210>  2187
<211>  315
<212>  PRT
<213>  Homo sapiens

<400>  2187

Met Gln Arg Arg Ser Arg Gly Ile Asn Thr Gly Leu Ile Leu Leu Leu 
1               5                   10                  15      


Ser Gln Ile Phe His Val Gly Ile Asn Asn Ile Pro Pro Val Thr Leu 
            20                  25                  30          


Ala Thr Leu Ala Leu Asn Ile Trp Phe Phe Leu Asn Pro Gln Lys Pro 
        35                  40                  45              


Leu Tyr Ser Ser Cys Leu Ser Val Glu Lys Cys Tyr Gln Gln Lys Asp 
    50                  55                  60                  


Trp Gln Arg Leu Leu Leu Ser Pro Leu His His Ala Asp Asp Trp His 
65                  70                  75                  80  


Leu Tyr Phe Asn Met Ala Ser Met Leu Trp Lys Gly Ile Asn Leu Glu 
                85                  90                  95      


Arg Arg Leu Gly Ser Arg Trp Phe Ala Tyr Val Ile Thr Ala Phe Ser 
            100                 105                 110         


Val Leu Thr Gly Val Val Tyr Leu Leu Leu Gln Phe Ala Val Ala Glu 
        115                 120                 125             


Phe Met Asp Glu Pro Asp Phe Lys Arg Ser Cys Ala Val Gly Phe Ser 
    130                 135                 140                 


Gly Val Leu Phe Ala Leu Lys Val Leu Asn Asn His Tyr Cys Pro Gly 
145                 150                 155                 160 


Gly Phe Val Asn Ile Leu Gly Phe Pro Val Pro Asn Arg Phe Ala Cys 
                165                 170                 175     


Trp Val Glu Leu Val Ala Ile His Leu Phe Ser Pro Gly Thr Ser Phe 
            180                 185                 190         


Ala Gly His Leu Ala Gly Ile Leu Val Gly Leu Met Tyr Thr Gln Gly 
        195                 200                 205             


Pro Leu Lys Lys Ile Met Glu Ala Cys Ala Gly Gly Phe Ser Ser Ser 
    210                 215                 220                 


Val Gly Tyr Pro Gly Arg Gln Tyr Tyr Phe Asn Ser Ser Gly Ser Ser 
225                 230                 235                 240 


Gly Tyr Gln Asp Tyr Tyr Pro His Gly Arg Pro Asp His Tyr Glu Glu 
                245                 250                 255     


Ala Pro Arg Asn Tyr Asp Thr Tyr Thr Ala Gly Leu Ser Glu Glu Glu 
            260                 265                 270         


Gln Leu Glu Arg Ala Leu Gln Ala Ser Leu Trp Asp Arg Gly Asn Thr 
        275                 280                 285             


Arg Asn Ser Pro Pro Pro Tyr Gly Phe His Leu Ser Pro Glu Glu Met 
    290                 295                 300                 


Arg Arg Gln Arg Leu His Arg Phe Asp Ser Gln 
305                 310                 315 


<210>  2188
<211>  910
<212>  PRT
<213>  Homo sapiens

<400>  2188

Met Ala Ala Ala Ala Ala Ser Ala Pro Gln Gln Leu Ser Asp Glu Glu 
1               5                   10                  15      


Leu Phe Ser Gln Leu Arg Arg Tyr Gly Leu Ser Pro Gly Pro Val Thr 
            20                  25                  30          


Glu Ser Thr Arg Pro Val Tyr Leu Lys Lys Leu Lys Lys Leu Arg Glu 
        35                  40                  45              


Glu Glu Gln Gln Gln His Arg Ser Gly Gly Arg Gly Asn Lys Thr Arg 
    50                  55                  60                  


Asn Ser Asn Asn Asn Asn Thr Ala Ala Ala Thr Val Ala Ala Ala Gly 
65                  70                  75                  80  


Pro Ala Ala Ala Ala Ala Ala Gly Met Gly Val Arg Pro Val Ser Gly 
                85                  90                  95      


Asp Leu Ser Tyr Leu Arg Thr Pro Gly Gly Leu Cys Arg Ile Ser Ala 
            100                 105                 110         


Ser Gly Pro Glu Ser Leu Leu Gly Gly Pro Gly Gly Ala Ser Ala Ala 
        115                 120                 125             


Pro Ala Ala Gly Ser Lys Val Leu Leu Gly Phe Ser Ser Asp Glu Ser 
    130                 135                 140                 


Asp Val Glu Ala Ser Pro Arg Asp Gln Ala Gly Gly Gly Gly Arg Lys 
145                 150                 155                 160 


Asp Arg Ala Ser Leu Gln Tyr Arg Gly Leu Lys Ala Pro Pro Ala Pro 
                165                 170                 175     


Leu Ala Ala Ser Glu Val Thr Asn Ser Asn Ser Ala Glu Arg Arg Lys 
            180                 185                 190         


Pro His Ser Trp Trp Gly Ala Arg Arg Pro Ala Gly Pro Glu Leu Gln 
        195                 200                 205             


Thr Pro Pro Gly Lys Asp Gly Ala Val Glu Asp Glu Glu Gly Glu Gly 
    210                 215                 220                 


Glu Asp Gly Glu Glu Arg Asp Pro Glu Thr Glu Glu Pro Leu Trp Ala 
225                 230                 235                 240 


Ser Arg Thr Val Asn Gly Ser Arg Leu Val Pro Tyr Ser Cys Arg Glu 
                245                 250                 255     


Asn Tyr Ser Asp Ser Glu Glu Glu Asp Asp Asp Asp Val Ala Ser Ser 
            260                 265                 270         


Arg Gln Val Leu Lys Asp Asp Ser Leu Ser Arg His Arg Pro Arg Arg 
        275                 280                 285             


Thr His Ser Lys Pro Leu Pro Pro Leu Thr Ala Lys Ser Ala Gly Gly 
    290                 295                 300                 


Arg Leu Glu Thr Ser Val Gln Gly Gly Gly Gly Leu Ala Met Asn Asp 
305                 310                 315                 320 


Arg Ala Ala Ala Ala Gly Ser Leu Asp Arg Ser Arg Asn Leu Glu Glu 
                325                 330                 335     


Ala Ala Ala Ala Glu Gln Gly Gly Gly Cys Asp Gln Val Asp Ser Ser 
            340                 345                 350         


Pro Val Pro Arg Tyr Arg Val Asn Ala Lys Lys Leu Thr Pro Leu Leu 
        355                 360                 365             


Pro Pro Pro Leu Thr Asp Met Asp Ser Thr Leu Asp Ser Ser Thr Gly 
    370                 375                 380                 


Ser Leu Leu Lys Thr Asn Asn His Ile Gly Gly Gly Ala Phe Ser Val 
385                 390                 395                 400 


Asp Ser Pro Arg Ile Tyr Ser Asn Ser Leu Pro Pro Ser Ala Ala Val 
                405                 410                 415     


Ala Ala Ser Ser Ser Leu Arg Ile Asn His Ala Asn His Thr Gly Ser 
            420                 425                 430         


Asn His Thr Tyr Leu Lys Asn Thr Tyr Asn Lys Pro Lys Leu Ser Glu 
        435                 440                 445             


Pro Glu Glu Glu Leu Leu Gln Gln Phe Lys Arg Glu Glu Val Ser Pro 
    450                 455                 460                 


Thr Gly Ser Phe Ser Ala His Tyr Leu Ser Met Phe Leu Leu Thr Ala 
465                 470                 475                 480 


Ala Cys Leu Phe Phe Leu Ile Leu Gly Leu Thr Tyr Leu Gly Met Arg 
                485                 490                 495     


Gly Thr Gly Val Ser Glu Asp Gly Glu Leu Ser Lys Asn Pro Phe Gly 
            500                 505                 510         


Glu Thr Phe Gly Lys Ile Gln Glu Ser Glu Lys Thr Leu Met Met Asn 
        515                 520                 525             


Thr Leu Tyr Lys Leu His Asp Arg Leu Ala Gln Leu Ala Gly Asp His 
    530                 535                 540                 


Glu Cys Gly Ser Ser Ser Gln Arg Thr Leu Ser Val Gln Glu Ala Ala 
545                 550                 555                 560 


Ala Tyr Leu Lys Asp Leu Gly Pro Glu Tyr Glu Gly Ile Phe Asn Thr 
                565                 570                 575     


Ser Leu Gln Trp Ile Leu Glu Asn Gly Lys Asp Val Gly Ile Arg Cys 
            580                 585                 590         


Val Gly Phe Gly Pro Glu Glu Glu Leu Thr Asn Ile Thr Asp Val Gln 
        595                 600                 605             


Phe Leu Gln Ser Thr Arg Pro Leu Met Ser Phe Trp Cys Arg Phe Arg 
    610                 615                 620                 


Arg Ala Phe Val Thr Val Thr His Arg Leu Leu Leu Leu Cys Leu Gly 
625                 630                 635                 640 


Val Val Met Val Cys Val Val Leu Arg Tyr Met Lys Tyr Arg Trp Thr 
                645                 650                 655     


Lys Glu Glu Glu Glu Thr Arg Gln Met Tyr Asp Met Val Val Lys Ile 
            660                 665                 670         


Ile Asp Val Leu Arg Ser His Asn Glu Ala Cys Gln Glu Asn Lys Asp 
        675                 680                 685             


Leu Gln Pro Tyr Met Pro Ile Pro His Val Arg Asp Ser Leu Ile Gln 
    690                 695                 700                 


Pro His Asp Arg Lys Lys Met Lys Lys Val Trp Asp Arg Ala Val Asp 
705                 710                 715                 720 


Phe Leu Ala Ala Asn Glu Ser Arg Val Arg Thr Glu Thr Arg Arg Ile 
                725                 730                 735     


Gly Gly Ala Asp Phe Leu Val Trp Arg Trp Ile Gln Pro Ser Ala Ser 
            740                 745                 750         


Cys Asp Lys Ile Leu Val Ile Pro Ser Lys Val Trp Gln Gly Gln Ala 
        755                 760                 765             


Phe His Leu Asp Arg Arg Asn Ser Pro Pro Asn Ser Leu Thr Pro Cys 
    770                 775                 780                 


Leu Lys Ile Arg Asn Met Phe Asp Pro Val Met Glu Ile Gly Asp Gln 
785                 790                 795                 800 


Trp His Leu Ala Ile Gln Glu Ala Ile Leu Glu Lys Cys Ser Asp Asn 
                805                 810                 815     


Asp Gly Ile Val His Ile Ala Val Asp Lys Asn Ser Arg Glu Gly Cys 
            820                 825                 830         


Val Tyr Val Lys Cys Leu Ser Pro Glu Tyr Ala Gly Lys Ala Phe Lys 
        835                 840                 845             


Ala Leu His Gly Ser Trp Phe Asp Gly Lys Leu Val Thr Val Lys Tyr 
    850                 855                 860                 


Leu Arg Leu Asp Arg Tyr His His Arg Phe Pro Gln Ala Leu Thr Ser 
865                 870                 875                 880 


Asn Thr Pro Leu Lys Pro Ser Asn Lys His Met Asn Ser Met Ser His 
                885                 890                 895     


Leu Arg Leu Arg Thr Gly Leu Thr Asn Ser Gln Gly Ser Ser 
            900                 905                 910 


<210>  2189
<211>  2138
<212>  PRT
<213>  Homo sapiens

<400>  2189

Met Val Asn Glu Asn Thr Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser Thr Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Thr Thr 
                85                  90                  95      


Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Thr 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Thr Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val 
        355                 360                 365             


Leu Tyr Trp Met Gln Asp Ala Met Gly Tyr Glu Leu Pro Trp Val Tyr 
    370                 375                 380                 


Phe Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Thr Glu Val Gln Asp Thr Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Thr Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr Ile Leu Val Glu Thr 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Thr Arg Arg Ser Thr 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Thr Val Phe Gln Ile Leu Thr 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Thr Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Thr Thr Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Thr Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Thr Thr Ile Phe 
    930                 935                 940                 


Thr Ile Glu Ile Ala Leu Lys Met Thr Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Thr Ile Gly  Asn Ile Val Ile Val  Thr Thr Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Thr Cys Ser Asp  Ser Ser Lys Gln Thr  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Thr  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Thr  Val Ser Thr 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Thr Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Thr Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Thr Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Thr 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Thr Gly  Leu Phe Thr 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys Gly Tyr 
    1265                 1270                 1275             


Phe Ser  Asp Pro Trp Asn Val  Phe Asp Phe Leu Ile  Val Ile Gly 
    1280                 1285                 1290             


Ser Ile  Ile Asp Val Ile Leu  Ser Glu Thr Asn Pro  Ala Glu His 
    1295                 1300                 1305             


Thr Gln  Cys Ser Pro Ser Met  Asn Ala Glu Glu Asn  Ser Arg Ile 
    1310                 1315                 1320             


Ser Ile  Thr Phe Phe Arg Leu  Phe Arg Val Met Arg  Leu Val Lys 
    1325                 1330                 1335             


Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Thr Leu Leu  Trp Thr Phe 
    1340                 1345                 1350             


Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Val 
    1355                 1360                 1365             


Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly Met Gln  Val Phe Gly 
    1370                 1375                 1380             


Lys Ile  Ala Leu Asn Asp Thr  Thr Glu Ile Asn Arg  Asn Asn Asn 
    1385                 1390                 1395             


Phe Gln  Thr Phe Pro Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala 
    1400                 1405                 1410             


Thr Gly  Glu Ala Trp Gln Asp  Ile Met Leu Ala Cys  Met Pro Gly 
    1415                 1420                 1425             


Lys Lys  Cys Ala Pro Glu Ser  Glu Pro Ser Asn Ser  Thr Glu Gly 
    1430                 1435                 1440             


Glu Thr  Pro Cys Gly Ser Ser  Phe Ala Val Phe Tyr  Phe Ile Ser 
    1445                 1450                 1455             


Phe Tyr  Met Leu Cys Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala 
    1460                 1465                 1470             


Val Ile  Met Asp Asn Phe Asp  Tyr Leu Thr Arg Asp  Trp Ser Ile 
    1475                 1480                 1485             


Leu Gly  Pro His His Leu Asp  Glu Phe Lys Arg Ile  Trp Ala Glu 
    1490                 1495                 1500             


Tyr Asp  Pro Glu Ala Lys Gly  Arg Ile Lys His Leu  Asp Val Val 
    1505                 1510                 1515             


Thr Leu  Leu Arg Arg Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu 
    1520                 1525                 1530             


Cys Pro  His Arg Val Ala Cys  Lys Arg Leu Val Ser  Met Asn Met 
    1535                 1540                 1545             


Pro Leu  Asn Ser Asp Gly Thr  Val Met Phe Asn Ala  Thr Leu Phe 
    1550                 1555                 1560             


Ala Leu  Val Arg Thr Ala Leu  Arg Ile Lys Thr Glu  Gly Asn Leu 
    1565                 1570                 1575             


Glu Gln  Ala Asn Glu Glu Leu  Arg Ala Ile Ile Lys  Lys Ile Trp 
    1580                 1585                 1590             


Lys Arg  Thr Ser Met Lys Leu  Leu Asp Gln Val Val  Pro Pro Ala 
    1595                 1600                 1605             


Gly Asp  Asp Glu Val Thr Val  Gly Lys Phe Tyr Ala  Thr Phe Leu 
    1610                 1615                 1620             


Ile Gln  Glu Tyr Phe Arg Lys  Phe Lys Lys Arg Lys  Glu Gln Gly 
    1625                 1630                 1635             


Leu Val  Gly Lys Pro Ser Gln  Arg Asn Ala Leu Ser  Leu Gln Ala 
    1640                 1645                 1650             


Gly Leu  Arg Thr Leu His Asp  Ile Gly Pro Glu Ile  Arg Arg Ala 
    1655                 1660                 1665             


Ile Ser  Gly Asp Leu Thr Ala  Glu Glu Glu Leu Asp  Lys Ala Met 
    1670                 1675                 1680             


Lys Glu  Ala Val Ser Ala Ala  Ser Glu Asp Asp Ile  Phe Arg Arg 
    1685                 1690                 1695             


Ala Gly  Gly Leu Phe Gly Asn  His Val Ser Tyr Tyr  Gln Ser Asp 
    1700                 1705                 1710             


Gly Arg  Ser Ala Phe Pro Gln  Thr Phe Thr Thr Gln  Arg Pro Leu 
    1715                 1720                 1725             


His Ile  Asn Lys Ala Gly Ser  Ser Gln Gly Asp Thr  Glu Ser Pro 
    1730                 1735                 1740             


Ser His  Glu Lys Leu Val Asp  Ser Thr Phe Thr Pro  Ser Ser Tyr 
    1745                 1750                 1755             


Ser Ser  Thr Gly Ser Asn Ala  Asn Ile Asn Asn Ala  Asn Asn Thr 
    1760                 1765                 1770             


Ala Leu  Gly Arg Leu Pro Arg  Pro Ala Gly Tyr Pro  Ser Thr Val 
    1775                 1780                 1785             


Ser Thr  Val Glu Gly His Gly  Pro Pro Leu Ser Pro  Ala Ile Arg 
    1790                 1795                 1800             


Val Gln  Glu Val Ala Trp Lys  Leu Ser Ser Asn Arg  Cys His Ser 
    1805                 1810                 1815             


Arg Glu  Ser Gln Ala Ala Met  Ala Gly Gln Glu Glu  Thr Ser Gln 
    1820                 1825                 1830             


Asp Glu  Thr Tyr Glu Val Lys  Met Asn His Asp Thr  Glu Ala Cys 
    1835                 1840                 1845             


Ser Glu  Pro Ser Leu Leu Ser  Thr Glu Met Leu Ser  Tyr Gln Asp 
    1850                 1855                 1860             


Asp Glu  Asn Arg Gln Leu Thr  Leu Pro Glu Glu Asp  Lys Arg Asp 
    1865                 1870                 1875             


Ile Arg  Gln Ser Pro Lys Arg  Gly Phe Leu Arg Ser  Ala Ser Leu 
    1880                 1885                 1890             


Gly Arg  Arg Ala Ser Phe His  Leu Glu Cys Leu Lys  Arg Gln Lys 
    1895                 1900                 1905             


Asp Arg  Gly Gly Asp Ile Ser  Gln Lys Thr Val Leu  Pro Leu His 
    1910                 1915                 1920             


Leu Val  His His Gln Ala Leu  Ala Val Ala Gly Leu  Ser Pro Leu 
    1925                 1930                 1935             


Leu Gln  Arg Ser His Ser Pro  Ala Ser Phe Pro Arg  Pro Phe Ala 
    1940                 1945                 1950             


Thr Pro  Pro Ala Thr Pro Gly  Ser Arg Gly Trp Pro  Pro Gln Pro 
    1955                 1960                 1965             


Val Pro  Thr Leu Arg Leu Glu  Gly Val Glu Ser Ser  Glu Lys Leu 
    1970                 1975                 1980             


Asn Ser  Ser Phe Pro Ser Ile  His Cys Gly Ser Trp  Ala Glu Thr 
    1985                 1990                 1995             


Thr Pro  Gly Gly Gly Gly Ser  Ser Ala Ala Arg Arg  Val Arg Pro 
    2000                 2005                 2010             


Val Ser  Leu Met Val Pro Ser  Gln Ala Gly Ala Pro  Gly Arg Gln 
    2015                 2020                 2025             


Phe His  Gly Ser Ala Ser Ser  Leu Val Glu Ala Val  Leu Ile Ser 
    2030                 2035                 2040             


Glu Gly  Leu Gly Gln Phe Ala  Gln Asp Pro Lys Phe  Ile Glu Val 
    2045                 2050                 2055             


Thr Thr  Gln Glu Leu Ala Asp  Ala Cys Asp Met Thr  Ile Glu Glu 
    2060                 2065                 2070             


Met Glu  Ser Ala Ala Asp Asn  Ile Leu Ser Gly Gly  Ala Pro Gln 
    2075                 2080                 2085             


Ser Pro  Asn Gly Ala Leu Leu  Pro Phe Val Asn Cys  Arg Asp Ala 
    2090                 2095                 2100             


Gly Gln  Asp Arg Ala Gly Gly  Glu Glu Asp Ala Gly  Cys Val Arg 
    2105                 2110                 2115             


Ala Arg  Gly Arg Pro Ser Glu  Glu Glu Leu Gln Asp  Ser Arg Val 
    2120                 2125                 2130             


Tyr Val  Ser Ser Leu 
    2135             


<210>  2190
<211>  2173
<212>  PRT
<213>  Homo sapiens

<400>  2190

Met Val Asn Glu Asn Thr Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser Thr Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Thr Thr 
                85                  90                  95      


Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Thr 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Thr Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val 
        355                 360                 365             


Leu Tyr Trp Met Gln Asp Ala Met Gly Tyr Glu Leu Pro Trp Val Tyr 
    370                 375                 380                 


Phe Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Thr Glu Val Gln Asp Thr Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Thr Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr Ile Leu Val Glu Thr 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Thr Arg Arg Ser Thr 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Thr Val Phe Gln Ile Leu Thr 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Thr Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Thr Thr Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Thr Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Thr Thr Ile Phe 
    930                 935                 940                 


Thr Ile Glu Ile Ala Leu Lys Met Thr Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Thr Ile Gly  Asn Ile Val Ile Val  Thr Thr Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Thr Cys Ser Asp  Ser Ser Lys Gln Thr  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Thr  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Thr  Val Ser Thr 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Thr Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Thr Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Thr Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Thr 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Thr Gly  Leu Phe Thr 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys Gly Tyr 
    1265                 1270                 1275             


Phe Ser  Asp Pro Trp Asn Val  Phe Asp Phe Leu Ile  Val Ile Gly 
    1280                 1285                 1290             


Ser Ile  Ile Asp Val Ile Leu  Ser Glu Thr Asn Pro  Ala Glu His 
    1295                 1300                 1305             


Thr Gln  Cys Ser Pro Ser Met  Asn Ala Glu Glu Asn  Ser Arg Ile 
    1310                 1315                 1320             


Ser Ile  Thr Phe Phe Arg Leu  Phe Arg Val Met Arg  Leu Val Lys 
    1325                 1330                 1335             


Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Thr Leu Leu  Trp Thr Phe 
    1340                 1345                 1350             


Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Val 
    1355                 1360                 1365             


Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly Met Gln  Val Phe Gly 
    1370                 1375                 1380             


Lys Ile  Ala Leu Asn Asp Thr  Thr Glu Ile Asn Arg  Asn Asn Asn 
    1385                 1390                 1395             


Phe Gln  Thr Phe Pro Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala 
    1400                 1405                 1410             


Thr Gly  Glu Ala Trp Gln Asp  Ile Met Leu Ala Cys  Met Pro Gly 
    1415                 1420                 1425             


Lys Lys  Cys Ala Pro Glu Ser  Glu Pro Ser Asn Ser  Thr Glu Gly 
    1430                 1435                 1440             


Glu Thr  Pro Cys Gly Ser Ser  Phe Ala Val Phe Tyr  Phe Ile Ser 
    1445                 1450                 1455             


Phe Tyr  Met Leu Cys Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala 
    1460                 1465                 1470             


Val Ile  Met Asp Asn Phe Asp  Tyr Leu Thr Arg Asp  Trp Ser Ile 
    1475                 1480                 1485             


Leu Gly  Pro His His Leu Asp  Glu Phe Lys Arg Ile  Trp Ala Glu 
    1490                 1495                 1500             


Tyr Asp  Pro Glu Ala Lys Gly  Arg Ile Lys His Leu  Asp Val Val 
    1505                 1510                 1515             


Thr Leu  Leu Arg Arg Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu 
    1520                 1525                 1530             


Cys Pro  His Arg Val Ala Cys  Lys Arg Leu Val Ser  Met Asn Met 
    1535                 1540                 1545             


Pro Leu  Asn Ser Asp Gly Thr  Val Met Phe Asn Ala  Thr Leu Phe 
    1550                 1555                 1560             


Ala Leu  Val Arg Thr Ala Leu  Arg Ile Lys Thr Glu  Gly Asn Leu 
    1565                 1570                 1575             


Glu Gln  Ala Asn Glu Glu Leu  Arg Ala Ile Ile Lys  Lys Ile Trp 
    1580                 1585                 1590             


Lys Arg  Thr Ser Met Lys Leu  Leu Asp Gln Val Val  Pro Pro Ala 
    1595                 1600                 1605             


Gly Asp  Asp Glu Val Thr Val  Gly Lys Phe Tyr Ala  Thr Phe Leu 
    1610                 1615                 1620             


Ile Gln  Glu Tyr Phe Arg Lys  Phe Lys Lys Arg Lys  Glu Gln Gly 
    1625                 1630                 1635             


Leu Val  Gly Lys Pro Ser Gln  Arg Asn Ala Leu Ser  Leu Gln Ala 
    1640                 1645                 1650             


Gly Leu  Arg Thr Leu His Asp  Ile Gly Pro Glu Ile  Arg Arg Ala 
    1655                 1660                 1665             


Ile Ser  Gly Asp Leu Thr Ala  Glu Glu Glu Leu Asp  Lys Ala Met 
    1670                 1675                 1680             


Lys Glu  Ala Val Ser Ala Ala  Ser Glu Asp Asp Ile  Phe Arg Arg 
    1685                 1690                 1695             


Ala Gly  Gly Leu Phe Gly Asn  His Val Ser Tyr Tyr  Gln Ser Asp 
    1700                 1705                 1710             


Gly Arg  Ser Ala Phe Pro Gln  Thr Phe Thr Thr Gln  Arg Pro Leu 
    1715                 1720                 1725             


His Ile  Asn Lys Ala Gly Ser  Ser Gln Gly Asp Thr  Glu Ser Pro 
    1730                 1735                 1740             


Ser His  Glu Lys Leu Val Asp  Ser Thr Phe Thr Pro  Ser Ser Tyr 
    1745                 1750                 1755             


Ser Ser  Thr Gly Ser Asn Ala  Asn Ile Asn Asn Ala  Asn Asn Thr 
    1760                 1765                 1770             


Ala Leu  Gly Arg Leu Pro Arg  Pro Ala Gly Tyr Pro  Ser Thr Val 
    1775                 1780                 1785             


Ser Thr  Val Glu Gly His Gly  Pro Pro Leu Ser Pro  Ala Ile Arg 
    1790                 1795                 1800             


Val Gln  Glu Val Ala Trp Lys  Leu Ser Ser Asn Arg  Glu Arg His 
    1805                 1810                 1815             


Val Pro  Met Cys Glu Asp Leu  Glu Leu Arg Arg Asp  Ser Gly Ser 
    1820                 1825                 1830             


Ala Gly  Thr Gln Ala His Cys  Leu Leu Leu Arg Arg  Ala Asn Pro 
    1835                 1840                 1845             


Ser Arg  Cys His Ser Arg Glu  Ser Gln Ala Ala Met  Ala Gly Gln 
    1850                 1855                 1860             


Glu Glu  Thr Ser Gln Asp Glu  Thr Tyr Glu Val Lys  Met Asn His 
    1865                 1870                 1875             


Asp Thr  Glu Ala Cys Ser Glu  Pro Ser Leu Leu Ser  Thr Glu Met 
    1880                 1885                 1890             


Leu Ser  Tyr Gln Asp Asp Glu  Asn Arg Gln Leu Thr  Leu Pro Glu 
    1895                 1900                 1905             


Glu Asp  Lys Arg Asp Ile Arg  Gln Ser Pro Lys Arg  Gly Phe Leu 
    1910                 1915                 1920             


Arg Ser  Ala Ser Leu Gly Arg  Arg Ala Ser Phe His  Leu Glu Cys 
    1925                 1930                 1935             


Leu Lys  Arg Gln Lys Asp Arg  Gly Gly Asp Ile Ser  Gln Lys Thr 
    1940                 1945                 1950             


Val Leu  Pro Leu His Leu Val  His His Gln Ala Leu  Ala Val Ala 
    1955                 1960                 1965             


Gly Leu  Ser Pro Leu Leu Gln  Arg Ser His Ser Pro  Ala Ser Phe 
    1970                 1975                 1980             


Pro Arg  Pro Phe Ala Thr Pro  Pro Ala Thr Pro Gly  Ser Arg Gly 
    1985                 1990                 1995             


Trp Pro  Pro Gln Pro Val Pro  Thr Leu Arg Leu Glu  Gly Val Glu 
    2000                 2005                 2010             


Ser Ser  Glu Lys Leu Asn Ser  Ser Phe Pro Ser Ile  His Cys Gly 
    2015                 2020                 2025             


Ser Trp  Ala Glu Thr Thr Pro  Gly Gly Gly Gly Ser  Ser Ala Ala 
    2030                 2035                 2040             


Arg Arg  Val Arg Pro Val Ser  Leu Met Val Pro Ser  Gln Ala Gly 
    2045                 2050                 2055             


Ala Pro  Gly Arg Gln Phe His  Gly Ser Ala Ser Ser  Leu Val Glu 
    2060                 2065                 2070             


Ala Val  Leu Ile Ser Glu Gly  Leu Gly Gln Phe Ala  Gln Asp Pro 
    2075                 2080                 2085             


Lys Phe  Ile Glu Val Thr Thr  Gln Glu Leu Ala Asp  Ala Cys Asp 
    2090                 2095                 2100             


Met Thr  Ile Glu Glu Met Glu  Ser Ala Ala Asp Asn  Ile Leu Ser 
    2105                 2110                 2115             


Gly Gly  Ala Pro Gln Ser Pro  Asn Gly Ala Leu Leu  Pro Phe Val 
    2120                 2125                 2130             


Asn Cys  Arg Asp Ala Gly Gln  Asp Arg Ala Gly Gly  Glu Glu Asp 
    2135                 2140                 2145             


Ala Gly  Cys Val Arg Ala Arg  Gly Arg Pro Ser Glu  Glu Glu Leu 
    2150                 2155                 2160             


Gln Asp  Ser Arg Val Tyr Val  Ser Ser Leu 
    2165                 2170             


<210>  2191
<211>  2198
<212>  PRT
<213>  Homo sapiens

<400>  2191

Met Val Asn Glu Asn Thr Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser Thr Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Thr Thr 
                85                  90                  95      


Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Thr 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Thr Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val 
        355                 360                 365             


Leu Tyr Trp Met Gln Asp Ala Met Gly Tyr Glu Leu Pro Trp Val Tyr 
    370                 375                 380                 


Phe Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Thr Glu Val Gln Asp Thr Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Thr Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr Ile Leu Val Glu Thr 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Thr Arg Arg Ser Thr 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Thr Val Phe Gln Ile Leu Thr 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Thr Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Thr Thr Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Thr Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Thr Thr Ile Phe 
    930                 935                 940                 


Thr Ile Glu Ile Ala Leu Lys Met Thr Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Thr Ile Gly  Asn Ile Val Ile Val  Thr Thr Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Thr Cys Ser Asp  Ser Ser Lys Gln Thr  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Thr  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Thr  Val Ser Thr 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Thr Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Thr Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Thr Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Thr 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Thr Gly  Leu Phe Thr 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys His Tyr 
    1265                 1270                 1275             


Phe Cys  Asp Ala Trp Asn Thr  Phe Asp Ala Leu Ile  Val Val Gly 
    1280                 1285                 1290             


Ser Ile  Val Asp Ile Ala Ile  Thr Glu Val Asn Asn  Ala Glu Glu 
    1295                 1300                 1305             


Asn Ser  Arg Ile Ser Ile Thr  Phe Phe Arg Leu Phe  Arg Val Met 
    1310                 1315                 1320             


Arg Leu  Val Lys Leu Leu Ser  Arg Gly Glu Gly Ile  Arg Thr Leu 
    1325                 1330                 1335             


Leu Trp  Thr Phe Ile Lys Ser  Phe Gln Ala Leu Pro  Tyr Val Ala 
    1340                 1345                 1350             


Leu Leu  Ile Val Met Leu Phe  Phe Ile Tyr Ala Val  Ile Gly Met 
    1355                 1360                 1365             


Gln Val  Phe Gly Lys Ile Ala  Leu Asn Asp Thr Thr  Glu Ile Asn 
    1370                 1375                 1380             


Arg Asn  Asn Asn Phe Gln Thr  Phe Pro Gln Ala Val  Leu Leu Leu 
    1385                 1390                 1395             


Phe Arg  Cys Ala Thr Gly Glu  Ala Trp Gln Asp Ile  Met Leu Ala 
    1400                 1405                 1410             


Cys Met  Pro Gly Lys Lys Cys  Ala Pro Glu Ser Glu  Pro Ser Asn 
    1415                 1420                 1425             


Ser Thr  Glu Gly Glu Thr Pro  Cys Gly Ser Ser Phe  Ala Val Phe 
    1430                 1435                 1440             


Tyr Phe  Ile Ser Phe Tyr Met  Leu Cys Ala Phe Leu  Ile Ile Asn 
    1445                 1450                 1455             


Leu Phe  Val Ala Val Ile Met  Asp Asn Phe Asp Tyr  Leu Thr Arg 
    1460                 1465                 1470             


Asp Trp  Ser Ile Leu Gly Pro  His His Leu Asp Glu  Phe Lys Arg 
    1475                 1480                 1485             


Ile Trp  Ala Glu Tyr Asp Pro  Glu Ala Lys Gly Arg  Ile Lys His 
    1490                 1495                 1500             


Leu Asp  Val Val Thr Leu Leu  Arg Arg Ile Gln Pro  Pro Leu Gly 
    1505                 1510                 1515             


Phe Gly  Lys Leu Cys Pro His  Arg Val Ala Cys Lys  Arg Leu Val 
    1520                 1525                 1530             


Ser Met  Asn Met Pro Leu Asn  Ser Asp Gly Thr Val  Met Phe Asn 
    1535                 1540                 1545             


Ala Thr  Leu Phe Ala Leu Val  Arg Thr Ala Leu Arg  Ile Lys Thr 
    1550                 1555                 1560             


Glu Gly  Asn Leu Glu Gln Ala  Asn Glu Glu Leu Arg  Ala Ile Ile 
    1565                 1570                 1575             


Lys Lys  Ile Trp Lys Arg Thr  Ser Met Lys Leu Leu  Asp Gln Val 
    1580                 1585                 1590             


Val Pro  Pro Ala Gly Asp Asp  Glu Val Thr Val Gly  Lys Phe Tyr 
    1595                 1600                 1605             


Ala Thr  Phe Leu Ile Gln Glu  Tyr Phe Arg Lys Phe  Lys Lys Arg 
    1610                 1615                 1620             


Lys Glu  Gln Gly Leu Val Gly  Lys Pro Ser Gln Arg  Asn Ala Leu 
    1625                 1630                 1635             


Ser Leu  Gln Ala Gly Leu Arg  Thr Leu His Asp Ile  Gly Pro Glu 
    1640                 1645                 1650             


Ile Arg  Arg Ala Ile Ser Gly  Asp Leu Thr Ala Glu  Glu Glu Leu 
    1655                 1660                 1665             


Asp Lys  Ala Met Lys Glu Ala  Val Ser Ala Ala Ser  Glu Asp Asp 
    1670                 1675                 1680             


Ile Phe  Arg Arg Ala Gly Gly  Leu Phe Gly Asn His  Val Ser Tyr 
    1685                 1690                 1695             


Tyr Gln  Ser Asp Gly Arg Ser  Ala Phe Pro Gln Thr  Phe Thr Thr 
    1700                 1705                 1710             


Gln Arg  Pro Leu His Ile Asn  Lys Ala Gly Ser Ser  Gln Gly Asp 
    1715                 1720                 1725             


Thr Glu  Ser Pro Ser His Glu  Lys Leu Val Asp Ser  Thr Phe Thr 
    1730                 1735                 1740             


Pro Ser  Ser Tyr Ser Ser Thr  Gly Ser Asn Ala Asn  Ile Asn Asn 
    1745                 1750                 1755             


Ala Asn  Asn Thr Ala Leu Gly  Arg Leu Pro Arg Pro  Ala Gly Tyr 
    1760                 1765                 1770             


Pro Ser  Thr Val Ser Thr Val  Glu Gly His Gly Pro  Pro Leu Ser 
    1775                 1780                 1785             


Pro Ala  Ile Arg Val Gln Glu  Val Ala Trp Lys Leu  Ser Ser Asn 
    1790                 1795                 1800             


Arg Met  His Cys Cys Asp Met  Leu Asp Gly Gly Thr  Phe Pro Pro 
    1805                 1810                 1815             


Ala Leu  Gly Pro Arg Arg Ala  Pro Pro Cys Leu His  Gln Gln Leu 
    1820                 1825                 1830             


Gln Gly  Ser Leu Ala Gly Leu  Arg Glu Asp Thr Pro  Cys Ile Val 
    1835                 1840                 1845             


Pro Gly  His Ala Ser Leu Cys  Cys Ser Ser Arg Val  Gly Glu Trp 
    1850                 1855                 1860             


Leu Pro  Ala Gly Cys Thr Ala  Pro Gln His Ala Arg  Cys His Ser 
    1865                 1870                 1875             


Arg Glu  Ser Gln Ala Ala Met  Ala Gly Gln Glu Glu  Thr Ser Gln 
    1880                 1885                 1890             


Asp Glu  Thr Tyr Glu Val Lys  Met Asn His Asp Thr  Glu Ala Cys 
    1895                 1900                 1905             


Ser Glu  Pro Ser Leu Leu Ser  Thr Glu Met Leu Ser  Tyr Gln Asp 
    1910                 1915                 1920             


Asp Glu  Asn Arg Gln Leu Thr  Leu Pro Glu Glu Asp  Lys Arg Asp 
    1925                 1930                 1935             


Ile Arg  Gln Ser Pro Lys Arg  Gly Phe Leu Arg Ser  Ala Ser Leu 
    1940                 1945                 1950             


Gly Arg  Arg Ala Ser Phe His  Leu Glu Cys Leu Lys  Arg Gln Lys 
    1955                 1960                 1965             


Asp Arg  Gly Gly Asp Ile Ser  Gln Lys Thr Val Leu  Pro Leu His 
    1970                 1975                 1980             


Leu Val  His His Gln Ala Leu  Ala Val Ala Gly Leu  Ser Pro Leu 
    1985                 1990                 1995             


Leu Gln  Arg Ser His Ser Pro  Ala Ser Phe Pro Arg  Pro Phe Ala 
    2000                 2005                 2010             


Thr Pro  Pro Ala Thr Pro Gly  Ser Arg Gly Trp Pro  Pro Gln Pro 
    2015                 2020                 2025             


Val Pro  Thr Leu Arg Leu Glu  Gly Val Glu Ser Ser  Glu Lys Leu 
    2030                 2035                 2040             


Asn Ser  Ser Phe Pro Ser Ile  His Cys Gly Ser Trp  Ala Glu Thr 
    2045                 2050                 2055             


Thr Pro  Gly Gly Gly Gly Ser  Ser Ala Ala Arg Arg  Val Arg Pro 
    2060                 2065                 2070             


Val Ser  Leu Met Val Pro Ser  Gln Ala Gly Ala Pro  Gly Arg Gln 
    2075                 2080                 2085             


Phe His  Gly Ser Ala Ser Ser  Leu Val Glu Ala Val  Leu Ile Ser 
    2090                 2095                 2100             


Glu Gly  Leu Gly Gln Phe Ala  Gln Asp Pro Lys Phe  Ile Glu Val 
    2105                 2110                 2115             


Thr Thr  Gln Glu Leu Ala Asp  Ala Cys Asp Met Thr  Ile Glu Glu 
    2120                 2125                 2130             


Met Glu  Ser Ala Ala Asp Asn  Ile Leu Ser Gly Gly  Ala Pro Gln 
    2135                 2140                 2145             


Ser Pro  Asn Gly Ala Leu Leu  Pro Phe Val Asn Cys  Arg Asp Ala 
    2150                 2155                 2160             


Gly Gln  Asp Arg Ala Gly Gly  Glu Glu Asp Ala Gly  Cys Val Arg 
    2165                 2170                 2175             


Ala Arg  Gly Arg Pro Ser Glu  Glu Glu Leu Gln Asp  Ser Arg Val 
    2180                 2185                 2190             


Tyr Val  Ser Ser Leu 
    2195             


<210>  2192
<211>  574
<212>  PRT
<213>  Homo sapiens

<400>  2192

Met Lys Ile Thr Ser Thr Ser Cys Ile Cys Pro Val Leu Val Cys Leu 
1               5                   10                  15      


Cys Phe Val Gln Arg Cys Tyr Gly Thr Ala His His Ser Ser Ile Lys 
            20                  25                  30          


Val Met Arg Asn Gln Thr Lys His Ile Glu Gly Glu Thr Glu Val His 
        35                  40                  45              


His Arg Pro Lys Arg Gly Trp Val Trp Asn Gln Phe Phe Val Leu Glu 
    50                  55                  60                  


Glu His Met Gly Pro Asp Pro Gln Tyr Val Gly Lys Leu His Ser Asn 
65                  70                  75                  80  


Ser Asp Lys Gly Asp Gly Ser Val Lys Tyr Ile Leu Thr Gly Glu Gly 
                85                  90                  95      


Ala Gly Thr Ile Phe Ile Ile Asp Asp Thr Thr Gly Asp Ile His Ser 
            100                 105                 110         


Thr Lys Ser Leu Asp Arg Glu Gln Lys Thr His Tyr Val Leu His Ala 
        115                 120                 125             


Gln Ala Ile Asp Arg Arg Thr Asn Lys Pro Leu Glu Pro Glu Ser Glu 
    130                 135                 140                 


Phe Ile Ile Lys Val Gln Asp Ile Asn Asp Asn Ala Pro Lys Phe Thr 
145                 150                 155                 160 


Asp Gly Pro Tyr Ile Val Thr Val Pro Glu Met Ser Asp Met Gly Thr 
                165                 170                 175     


Ser Val Leu Gln Val Thr Ala Thr Asp Ala Asp Asp Pro Thr Tyr Gly 
            180                 185                 190         


Asn Ser Ala Arg Val Val Tyr Ser Ile Leu Gln Gly Gln Pro Tyr Phe 
        195                 200                 205             


Ser Val Asp Pro Lys Thr Gly Val Ile Arg Thr Ala Leu His Asn Met 
    210                 215                 220                 


Asp Arg Glu Ala Arg Glu His Tyr Ser Val Val Ile Gln Ala Lys Asp 
225                 230                 235                 240 


Met Ala Gly Gln Val Gly Gly Leu Ser Gly Ser Thr Thr Val Asn Ile 
                245                 250                 255     


Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Arg Phe Pro Gln Lys His 
            260                 265                 270         


Tyr Gln Leu Tyr Val Pro Glu Ser Ala Gln Val Gly Ser Ala Val Gly 
        275                 280                 285             


Lys Ile Lys Ala Asn Asp Ala Asp Thr Gly Ser Asn Ala Asp Met Thr 
    290                 295                 300                 


Tyr Ser Ile Ile Asn Gly Asp Gly Met Gly Ile Phe Ser Ile Ser Thr 
305                 310                 315                 320 


Asp Lys Glu Thr Arg Glu Gly Ile Leu Ser Leu Lys Lys Pro Leu Asn 
                325                 330                 335     


Tyr Glu Lys Lys Lys Ser Tyr Thr Leu Asn Ile Glu Gly Ala Asn Thr 
            340                 345                 350         


His Leu Asp Phe Arg Phe Ser His Leu Gly Pro Phe Lys Asp Ala Thr 
        355                 360                 365             


Met Leu Lys Ile Ile Val Gly Asp Val Asp Glu Pro Pro Leu Phe Ser 
    370                 375                 380                 


Met Pro Ser Tyr Leu Met Glu Val Tyr Glu Asn Ala Lys Ile Gly Thr 
385                 390                 395                 400 


Val Val Gly Thr Val Leu Ala Gln Asp Pro Asp Ser Thr Asn Ser Leu 
                405                 410                 415     


Val Arg Tyr Phe Ile Asn Tyr Asn Val Glu Asp Asp Arg Phe Phe Asn 
            420                 425                 430         


Ile Asp Ala Asn Thr Gly Thr Ile Arg Thr Thr Lys Val Leu Asp Arg 
        435                 440                 445             


Glu Glu Thr Pro Trp Tyr Asn Ile Thr Val Thr Ala Ser Glu Ile Asp 
    450                 455                 460                 


Asn Pro Asp Leu Leu Ser His Val Thr Val Gly Ile Arg Val Leu Asp 
465                 470                 475                 480 


Val Asn Asp Asn Pro Pro Glu Leu Ala Arg Glu Tyr Asp Ile Ile Val 
                485                 490                 495     


Cys Glu Asn Ser Lys Pro Gly Gln Val Ile His Thr Ile Ser Ala Thr 
            500                 505                 510         


Asp Lys Asp Asp Phe Ala Asn Gly Pro Arg Phe Asn Phe Phe Leu Asp 
        515                 520                 525             


Glu Arg Leu Pro Val Asn Pro Asn Phe Thr Leu Lys Asp Asn Glu Ala 
    530                 535                 540                 


Ala Ala Pro Ser Pro Ser Gly Phe Val His Ala Arg Glu Met Gly Val 
545                 550                 555                 560 


Cys Gly Pro Ala Met Gln Lys Pro Ser Cys Pro Arg Leu Val 
                565                 570                 


<210>  2193
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  2193

Met Met Gln Gln Pro Arg Val Glu Thr Asp Thr Ile Gly Ala Gly Glu 
1               5                   10                  15      


Gly Pro Gln Gln Ala Val Pro Trp Ser Ala Trp Val Thr Arg His Gly 
            20                  25                  30          


Trp Val Arg Trp Trp Val Ser His Met Pro Pro Ser Trp Ile Gln Trp 
        35                  40                  45              


Trp Ser Thr Ser Asn Trp Arg Gln Pro Leu Gln Arg Leu Leu Trp Gly 
    50                  55                  60                  


Leu Glu Gly Ile Leu Tyr Leu Leu Leu Ala Leu Met Leu Cys His Ala 
65                  70                  75                  80  


Leu Phe Thr Thr Gly Ser His Leu Leu Ser Ser Leu Trp Pro Val Val 
                85                  90                  95      


Ala Ala Val Trp Arg His Leu Leu Pro Ala Leu Leu Leu Leu Val Leu 
            100                 105                 110         


Ser Ala Leu Pro Ala Leu Leu Phe Thr Ala Ser Phe Leu Leu Leu Phe 
        115                 120                 125             


Ser Thr Leu Leu Ser Leu Val Gly Leu Leu Thr Ser Met Thr His Pro 
    130                 135                 140                 


Gly Asp Thr Gln Asp Leu Asp Gln 
145                 150         


<210>  2194
<211>  435
<212>  PRT
<213>  Homo sapiens

<400>  2194

Met Ile Trp Lys Arg Ser Ala Val Leu Arg Phe Tyr Ser Val Cys Gly 
1               5                   10                  15      


Leu Leu Leu Gln Gly Ser Gln Gly Gln Phe Pro Leu Thr Gln Asn Val 
            20                  25                  30          


Thr Val Val Glu Gly Gly Thr Ala Ile Leu Thr Cys Arg Val Asp Gln 
        35                  40                  45              


Asn Asp Asn Thr Ser Leu Gln Trp Ser Asn Pro Ala Gln Gln Thr Leu 
    50                  55                  60                  


Tyr Phe Asp Asp Lys Lys Ala Leu Arg Asp Asn Arg Ile Glu Leu Val 
65                  70                  75                  80  


Arg Ala Ser Trp His Glu Leu Ser Ile Ser Val Ser Asp Val Ser Leu 
                85                  90                  95      


Ser Asp Glu Gly Gln Tyr Thr Cys Ser Leu Phe Thr Met Pro Val Lys 
            100                 105                 110         


Thr Ser Lys Ala Tyr Leu Thr Val Leu Gly Val Pro Glu Lys Pro Gln 
        115                 120                 125             


Ile Ser Gly Phe Ser Ser Pro Val Met Glu Gly Asp Leu Met Gln Leu 
    130                 135                 140                 


Thr Cys Lys Thr Ser Gly Ser Lys Pro Ala Ala Asp Ile Arg Trp Phe 
145                 150                 155                 160 


Lys Asn Asp Lys Glu Ile Lys Asp Val Lys Tyr Leu Lys Glu Glu Asp 
                165                 170                 175     


Ala Asn Arg Lys Thr Phe Thr Val Ser Ser Thr Leu Asp Phe Arg Val 
            180                 185                 190         


Asp Arg Ser Asp Asp Gly Val Ala Val Ile Cys Arg Val Asp His Glu 
        195                 200                 205             


Ser Leu Asn Ala Thr Pro Gln Val Ala Met Gln Val Leu Glu Ile His 
    210                 215                 220                 


Tyr Thr Pro Ser Val Lys Ile Ile Pro Ser Thr Pro Phe Pro Gln Glu 
225                 230                 235                 240 


Gly Gln Pro Leu Ile Leu Thr Cys Glu Ser Lys Gly Lys Pro Leu Pro 
                245                 250                 255     


Glu Pro Val Leu Trp Thr Lys Asp Gly Gly Glu Leu Pro Asp Pro Asp 
            260                 265                 270         


Arg Met Val Val Ser Gly Arg Glu Leu Asn Ile Leu Phe Leu Asn Lys 
        275                 280                 285             


Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Thr Asn Thr Ile Gly Gln 
    290                 295                 300                 


Ser Ser Ala Glu Tyr Val Leu Ile Val His Asp Val Pro Asn Thr Leu 
305                 310                 315                 320 


Leu Pro Thr Thr Ile Ile Pro Ser Leu Thr Thr Ala Thr Val Thr Thr 
                325                 330                 335     


Thr Val Ala Ile Thr Thr Ser Pro Thr Thr Ser Ala Thr Thr Ser Ser 
            340                 345                 350         


Ile Arg Asp Pro Asn Ala Leu Ala Gly Gln Asn Gly Pro Asp His Ala 
        355                 360                 365             


Leu Ile Gly Gly Ile Val Ala Val Val Val Phe Val Thr Leu Cys Ser 
    370                 375                 380                 


Ile Phe Leu Leu Gly Arg Tyr Leu Ala Arg His Lys Gly Thr Tyr Leu 
385                 390                 395                 400 


Thr Asn Glu Ala Lys Gly Ala Glu Asp Ala Pro Asp Ala Asp Thr Ala 
                405                 410                 415     


Ile Ile Asn Ala Glu Gly Ser Gln Val Asn Ala Glu Glu Lys Lys Glu 
            420                 425                 430         


Tyr Phe Ile 
        435 


<210>  2195
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  2195

Met Ile Trp Lys Arg Ser Ala Val Leu Arg Phe Tyr Ser Val Cys Gly 
1               5                   10                  15      


Leu Leu Leu Gln Ala Ala Ala Ser Lys Asn Lys Val Lys Gly Ser Gln 
            20                  25                  30          


Gly Gln Phe Pro Leu Thr Gln Asn Val Thr Val Val Glu Gly Gly Thr 
        35                  40                  45              


Ala Ile Leu Thr Cys Arg Val Asp Gln Asn Asp Asn Thr Ser Leu Gln 
    50                  55                  60                  


Trp Ser Asn Pro Ala Gln Gln Thr Leu Tyr Phe Asp Asp Lys Lys Ala 
65                  70                  75                  80  


Leu Arg Asp Asn Arg Ile Glu Leu Val Arg Ala Ser Trp His Glu Leu 
                85                  90                  95      


Ser Ile Ser Val Ser Asp Val Ser Leu Ser Asp Glu Gly Gln Tyr Thr 
            100                 105                 110         


Cys Ser Leu Phe Thr Met Pro Val Lys Thr Ser Lys Ala Tyr Leu Thr 
        115                 120                 125             


Val Leu Gly Val Pro Glu Lys Pro Gln Ile Ser Gly Phe Ser Ser Pro 
    130                 135                 140                 


Val Met Glu Gly Asp Leu Met Gln Leu Thr Cys Lys Thr Ser Gly Ser 
145                 150                 155                 160 


Lys Pro Ala Ala Asp Ile Arg Trp Phe Lys Asn Asp Lys Glu Ile Lys 
                165                 170                 175     


Asp Val Lys Tyr Leu Lys Glu Glu Asp Ala Asn Arg Lys Thr Phe Thr 
            180                 185                 190         


Val Ser Ser Thr Leu Asp Phe Arg Val Asp Arg Ser Asp Asp Gly Val 
        195                 200                 205             


Ala Val Ile Cys Arg Val Asp His Glu Ser Leu Asn Ala Thr Pro Gln 
    210                 215                 220                 


Val Ala Met Gln Val Leu Glu Ile His Tyr Thr Pro Ser Val Lys Ile 
225                 230                 235                 240 


Ile Pro Ser Thr Pro Phe Pro Gln Glu Gly Gln Pro Leu Ile Leu Thr 
                245                 250                 255     


Cys Glu Ser Lys Gly Lys Pro Leu Pro Glu Pro Val Leu Trp Thr Lys 
            260                 265                 270         


Asp Gly Gly Glu Leu Pro Asp Pro Asp Arg Met Val Val Ser Gly Arg 
        275                 280                 285             


Glu Leu Asn Ile Leu Phe Leu Asn Lys Thr Asp Asn Gly Thr Tyr Arg 
    290                 295                 300                 


Cys Glu Ala Thr Asn Thr Ile Gly Gln Ser Ser Ala Glu Tyr Val Leu 
305                 310                 315                 320 


Ile Val His Asp Pro Asn Ala Leu Ala Gly Gln Asn Gly Pro Asp His 
                325                 330                 335     


Ala Leu Ile Gly Gly Ile Val Ala Val Val Val Phe Val Thr Leu Cys 
            340                 345                 350         


Ser Ile Phe Leu Leu Gly Arg Tyr Leu Ala Arg His Lys Gly Thr Tyr 
        355                 360                 365             


Leu Thr Asn Glu Ala Lys Gly Ala Glu Asp Ala Pro Asp Ala Asp Thr 
    370                 375                 380                 


Ala Ile Ile Asn Ala Glu Gly Ser Gln Val Asn Ala Glu Glu Lys Lys 
385                 390                 395                 400 


Glu Tyr Phe Ile 
                


<210>  2196
<211>  1457
<212>  PRT
<213>  Homo sapiens

<400>  2196

Met Leu Val Phe Gly Asp Glu Thr His Ser His Phe Leu Val Ile Gly 
1               5                   10                  15      


Gln Ala Val Asp Asp Val Arg Leu Ala Gln Asn Met Ala Gln Met Asn 
            20                  25                  30          


Asp Val Ile Leu Ser Pro Asn Cys Trp Gln Leu Cys Asp Arg Ser Met 
        35                  40                  45              


Ile Glu Ile Glu Ser Val Pro Asp Gln Arg Ala Val Lys Val Asn Phe 
    50                  55                  60                  


Leu Lys Pro Pro Pro Asn Phe Asn Phe Asp Glu Phe Phe Thr Lys Cys 
65                  70                  75                  80  


Thr Thr Phe Met His Tyr Tyr Pro Ser Gly Glu His Lys Asn Leu Leu 
                85                  90                  95      


Arg Leu Ala Cys Thr Leu Lys Pro Asp Pro Glu Leu Glu Met Ser Leu 
            100                 105                 110         


Gln Lys Tyr Val Met Glu Ser Ile Leu Lys Gln Ile Asp Asn Lys Gln 
        115                 120                 125             


Leu Gln Gly Tyr Leu Ser Glu Leu Arg Pro Val Thr Ile Val Phe Val 
    130                 135                 140                 


Asn Leu Met Phe Glu Asp Gln Asp Lys Ala Glu Glu Ile Gly Pro Ala 
145                 150                 155                 160 


Ile Gln Asp Ala Tyr Met His Ile Thr Ser Val Leu Lys Ile Phe Gln 
                165                 170                 175     


Gly Gln Ile Asn Lys Val Phe Met Phe Asp Lys Gly Cys Ser Phe Leu 
            180                 185                 190         


Cys Val Phe Gly Phe Pro Gly Glu Lys Val Pro Asp Glu Leu Thr His 
        195                 200                 205             


Ala Leu Glu Cys Ala Met Asp Ile Phe Asp Phe Cys Ser Gln Val His 
    210                 215                 220                 


Lys Ile Gln Thr Val Ser Ile Gly Val Ala Ser Gly Ile Val Phe Cys 
225                 230                 235                 240 


Gly Ile Val Gly His Thr Val Arg His Glu Tyr Thr Val Ile Gly Gln 
                245                 250                 255     


Lys Val Asn Leu Ala Ala Arg Met Met Met Tyr Tyr Pro Gly Ile Val 
            260                 265                 270         


Thr Cys Asp Ser Val Thr Tyr Asn Gly Ser Asn Leu Pro Ala Tyr Phe 
        275                 280                 285             


Phe Lys Glu Leu Pro Lys Lys Val Met Lys Gly Val Ala Asp Ser Gly 
    290                 295                 300                 


Pro Leu Tyr Gln Tyr Trp Gly Arg Thr Glu Lys Val Met Phe Gly Met 
305                 310                 315                 320 


Ala Cys Leu Ile Cys Asn Arg Lys Glu Asp Tyr Pro Leu Leu Gly Arg 
                325                 330                 335     


Asn Lys Glu Ile Asn Tyr Phe Met Tyr Thr Met Lys Lys Phe Leu Ile 
            340                 345                 350         


Ser Asn Ser Ser Gln Val Leu Met Tyr Glu Gly Leu Pro Gly Tyr Gly 
        355                 360                 365             


Lys Ser Gln Ile Leu Met Lys Ile Glu Tyr Leu Ala Gln Gly Lys Asn 
    370                 375                 380                 


His Arg Ile Ile Ala Ile Ser Leu Asn Lys Ile Ser Phe His Gln Thr 
385                 390                 395                 400 


Phe Tyr Thr Ile Gln Met Phe Met Ala Asn Val Leu Gly Leu Asp Thr 
                405                 410                 415     


Cys Lys His Tyr Lys Glu Arg Gln Thr Asn Leu Arg Asn Lys Val Met 
            420                 425                 430         


Thr Leu Leu Asp Glu Lys Phe Tyr Cys Leu Leu Asn Asp Ile Phe His 
        435                 440                 445             


Val Gln Phe Pro Ile Ser Arg Glu Ile Ser Arg Met Ser Thr Leu Lys 
    450                 455                 460                 


Lys Gln Lys Gln Leu Glu Ile Leu Phe Met Lys Ile Leu Lys Leu Ile 
465                 470                 475                 480 


Val Lys Glu Glu Arg Ile Ile Phe Ile Ile Asp Glu Ala Gln Phe Val 
                485                 490                 495     


Asp Ser Thr Ser Trp Arg Phe Met Glu Lys Leu Ile Arg Thr Leu Pro 
            500                 505                 510         


Ile Phe Ile Ile Met Ser Leu Cys Pro Phe Val Asn Ile Pro Cys Ala 
        515                 520                 525             


Ala Ala Arg Ala Val Ile Lys Asn Arg Asn Thr Thr Tyr Ile Val Ile 
    530                 535                 540                 


Gly Ala Val Gln Pro Asn Asp Ile Ser Asn Lys Ile Cys Leu Asp Leu 
545                 550                 555                 560 


Asn Val Ser Cys Ile Ser Lys Glu Leu Asp Ser Tyr Leu Gly Glu Gly 
                565                 570                 575     


Ser Cys Gly Ile Pro Phe Tyr Cys Glu Glu Leu Leu Lys Asn Leu Glu 
            580                 585                 590         


His His Glu Val Leu Val Phe Gln Gln Thr Glu Ser Glu Glu Lys Thr 
        595                 600                 605             


Asn Arg Thr Trp Asn Asn Leu Phe Lys Tyr Ser Ile Lys Leu Thr Glu 
    610                 615                 620                 


Lys Leu Asn Met Val Thr Leu His Ser Asp Lys Glu Ser Glu Glu Val 
625                 630                 635                 640 


Cys His Leu Thr Ser Gly Val Arg Leu Lys Asn Leu Ser Pro Pro Thr 
                645                 650                 655     


Ser Leu Lys Glu Ile Ser Leu Ile Gln Leu Asp Ser Met Arg Leu Ser 
            660                 665                 670         


His Gln Met Leu Val Arg Cys Ala Ala Ile Ile Gly Leu Thr Phe Thr 
        675                 680                 685             


Thr Glu Leu Leu Phe Glu Ile Leu Pro Cys Trp Asn Met Lys Met Met 
    690                 695                 700                 


Ile Lys Thr Leu Ala Thr Leu Val Glu Ser Asn Ile Phe Tyr Cys Phe 
705                 710                 715                 720 


Arg Asn Gly Lys Glu Leu Gln Lys Ala Leu Lys Gln Asn Asp Pro Ser 
                725                 730                 735     


Phe Glu Val His Tyr Arg Ser Leu Ser Leu Lys Pro Ser Glu Gly Met 
            740                 745                 750         


Asp His Gly Glu Glu Glu Gln Leu Arg Glu Leu Glu Asn Glu Val Ile 
        755                 760                 765             


Glu Cys His Arg Ile Arg Phe Cys Asn Pro Met Met Gln Lys Thr Ala 
    770                 775                 780                 


Tyr Glu Leu Trp Leu Lys Asp Gln Arg Lys Ala Met His Leu Lys Cys 
785                 790                 795                 800 


Ala Arg Phe Leu Glu Glu Asp Ala His Arg Cys Asp His Cys Arg Gly 
                805                 810                 815     


Arg Asp Phe Ile Pro Tyr His His Phe Thr Val Asn Ile Arg Leu Asn 
            820                 825                 830         


Ala Leu Asp Met Asp Ala Ile Lys Lys Met Ala Met Ser His Gly Phe 
        835                 840                 845             


Lys Thr Glu Glu Lys Leu Ile Leu Ser Asn Ser Glu Ile Pro Glu Thr 
    850                 855                 860                 


Ser Ala Phe Phe Pro Glu Asn Arg Ser Pro Glu Glu Ile Arg Glu Lys 
865                 870                 875                 880 


Ile Leu Asn Phe Phe Asp His Val Leu Thr Lys Met Lys Thr Ser Asp 
                885                 890                 895     


Glu Asp Ile Ile Pro Leu Glu Ser Cys Gln Cys Glu Glu Ile Leu Glu 
            900                 905                 910         


Ile Val Ile Leu Pro Leu Ala His His Phe Leu Ala Leu Gly Glu Asn 
        915                 920                 925             


Asp Lys Ala Leu Tyr Tyr Phe Leu Glu Ile Ala Ser Ala Tyr Leu Ile 
    930                 935                 940                 


Phe Cys Asp Asn Tyr Met Ala Tyr Met Tyr Leu Asn Glu Gly Gln Lys 
945                 950                 955                 960 


Leu Leu Lys Thr Leu Lys Lys Asp Lys Ser Trp Ser Gln Thr Phe Glu 
                965                 970                 975     


Ser Ala Thr Phe Tyr Ser Leu Lys Gly Glu Val Cys Phe Asn Met Gly 
            980                 985                 990         


Gln Ile Val Leu Ala Lys Lys Met  Leu Arg Lys Ala Leu  Lys Leu Leu 
        995                 1000                 1005             


Asn Arg  Ile Phe Pro Tyr Asn  Leu Ile Ser Leu Phe  Leu His Ile 
    1010                 1015                 1020             


His Val  Glu Lys Asn Arg His  Phe His Tyr Val Asn  Arg Gln Ala 
    1025                 1030                 1035             


Gln Glu  Ser Pro Pro Pro Gly  Lys Lys Arg Leu Ala  Gln Leu Tyr 
    1040                 1045                 1050             


Arg Gln  Thr Val Cys Leu Ser  Leu Leu Trp Arg Ile  Tyr Ser Tyr 
    1055                 1060                 1065             


Ser Tyr  Leu Phe His Cys Lys  Tyr Tyr Ala His Leu  Ala Val Met 
    1070                 1075                 1080             


Met Gln  Met Asn Thr Ala Leu  Glu Thr Gln Asn Cys  Phe Gln Ile 
    1085                 1090                 1095             


Ile Lys  Ala Tyr Leu Asp Tyr  Ser Leu Tyr His His  Leu Ala Gly 
    1100                 1105                 1110             


Tyr Lys  Gly Val Trp Phe Lys  Tyr Glu Val Met Ala  Met Glu His 
    1115                 1120                 1125             


Ile Phe  Asn Leu Pro Leu Lys  Gly Glu Gly Ile Glu  Ile Val Ala 
    1130                 1135                 1140             


Tyr Val  Ala Glu Thr Leu Val  Phe Asn Lys Leu Ile  Met Gly His 
    1145                 1150                 1155             


Leu Asp  Leu Ala Ile Glu Leu  Gly Ser Arg Ala Leu  Gln Met Trp 
    1160                 1165                 1170             


Ala Leu  Leu Gln Asn Pro Asn  Arg His Tyr Gln Ser  Leu Cys Arg 
    1175                 1180                 1185             


Leu Ser  Arg Cys Leu Leu Leu  Asn Ser Arg Tyr Pro  Gln Leu Ile 
    1190                 1195                 1200             


Gln Val  Leu Gly Arg Leu Trp  Glu Leu Ser Val Thr  Gln Glu His 
    1205                 1210                 1215             


Ile Phe  Ser Lys Ala Phe Phe  Tyr Phe Val Cys Leu  Asp Ile Leu 
    1220                 1225                 1230             


Leu Tyr  Ser Gly Phe Val Tyr  Arg Thr Phe Glu Glu  Cys Leu Glu 
    1235                 1240                 1245             


Phe Ile  His Gln Tyr Glu Asn  Asn Arg Ile Leu Lys  Phe His Ser 
    1250                 1255                 1260             


Gly Leu  Leu Leu Gly Leu Tyr  Ser Ser Val Ala Ile  Trp Tyr Ala 
    1265                 1270                 1275             


Arg Leu  Gln Glu Trp Asp Asn  Phe Tyr Lys Phe Ser  Asn Arg Ala 
    1280                 1285                 1290             


Lys Asn  Leu Leu Pro Arg Arg  Thr Met Thr Leu Thr  Tyr Tyr Asp 
    1295                 1300                 1305             


Gly Ile  Ser Arg Tyr Met Glu  Gly Gln Val Leu His  Leu Gln Lys 
    1310                 1315                 1320             


Gln Ile  Lys Glu Gln Ser Glu  Asn Ala Gln Ala Ser  Gly Glu Glu 
    1325                 1330                 1335             


Leu Leu  Lys Asn Leu Glu Asn  Leu Val Ala Gln Asn  Thr Thr Gly 
    1340                 1345                 1350             


Pro Val  Phe Cys Pro Arg Leu  Tyr His Leu Met Ala  Tyr Val Cys 
    1355                 1360                 1365             


Ile Leu  Met Gly Asp Gly Gln  Lys Cys Gly Leu Phe  Leu Asn Thr 
    1370                 1375                 1380             


Ala Leu  Arg Leu Ser Glu Thr  Gln Gly Asn Ile Leu  Glu Lys Cys 
    1385                 1390                 1395             


Trp Leu  Asn Met Asn Lys Glu  Ser Trp Tyr Ser Thr  Ser Glu Leu 
    1400                 1405                 1410             


Lys Glu  Asp Gln Trp Leu Gln  Thr Ile Leu Ser Leu  Pro Ser Trp 
    1415                 1420                 1425             


Glu Lys  Ile Val Ala Gly Arg  Val Asn Ile Gln Asp  Leu Gln Lys 
    1430                 1435                 1440             


Asn Lys  Phe Leu Met Arg Ala  Asn Thr Val Asp Asn  His Phe 
    1445                 1450                 1455         


<210>  2197
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  2197

Met Ser Val Leu Thr Ser Pro Arg Gly Lys Val Glu Val Val His Cys 
1               5                   10                  15      


Arg Arg Thr Glu Ser Gln Asp Val Tyr Cys Ile Lys Ser Leu Ile Arg 
            20                  25                  30          


Lys Phe Thr Cys Lys Leu Phe Gly Lys Leu Asn Ile Ile Tyr Leu Leu 
        35                  40                  45              


Glu Lys Ala Asn Leu Ala Val Thr Leu Cys Asn Asp Lys Glu Glu Ile 
    50                  55                  60                  


Met Ala Gln Ala Thr Phe Leu Asp Tyr Pro Asn Trp Asn Val Ala Lys 
65                  70                  75                  80  


Gln Asp Asp Trp Val Ser Val Phe Arg Glu Leu Asp Ser Asp Ile Pro 
                85                  90                  95      


Cys Thr Pro Leu Asn Thr Leu Phe Met His Leu Phe Val Ala Val Asp 
            100                 105                 110         


Glu Tyr Ser Val Gly Cys Cys Lys Glu Ile Leu Arg Thr Val Tyr Lys 
        115                 120                 125             


Ala Val Pro Glu Leu His Phe Ile Phe Leu Ile Val Pro Ser Tyr Met 
    130                 135                 140                 


Ser Leu Gly Ser Thr Leu Ile Thr Val Phe Asp Gln Val Gly Asn Ile 
145                 150                 155                 160 


Pro Cys Leu Thr Tyr Glu Glu Asp Phe Ala Val His Ile Cys His Arg 
                165                 170                 175     


His Ser His Tyr Pro Gln Leu His Val Arg Lys Ala Arg Val Glu Asp 
            180                 185                 190         


His Asp Asp Leu Met Pro Ile Phe Met Arg Tyr Asp Thr Ile Leu Lys 
        195                 200                 205             


Glu Thr Tyr Gly Glu Tyr Phe Leu Ala Glu Leu Ile Glu Ala Gln Asp 
    210                 215                 220                 


Glu Glu Asn His Ala Val Val Cys Glu Val Glu Gly Thr Ala Val Gly 
225                 230                 235                 240 


Phe Met Ser Val Cys Ser Arg Val Asn Met Gln Leu Leu His Glu Cys 
                245                 250                 255     


Phe Asp Leu Gly Pro Phe His Gly Leu Cys Phe Pro His Pro Asp Asp 
            260                 265                 270         


Val Leu Glu Ser Pro Gln Asp Leu Ser Val Arg Arg Ser Gln Asp Ala 
        275                 280                 285             


Glu Leu Arg Ser Ser Ser Gln Gly Ser Gln Lys Ile Val Glu Glu Leu 
    290                 295                 300                 


Gln Glu Pro Val Ser Pro Asp Thr Met Glu Asn Ile Gln Gly Asn Ile 
305                 310                 315                 320 


Ala Arg Glu Ala Ala Ser Glu Glu Ala Leu Thr Ala Val Gln Ser Gly 
                325                 330                 335     


Asn Val Ser Glu Pro Glu Asp Ile Glu Lys Leu Ser Asp Ile Ser Thr 
            340                 345                 350         


Gly Tyr Ala Gln Tyr His His Val Ser Ser Arg Ser Leu Ala Ser Leu 
        355                 360                 365             


Val Leu Pro Glu Glu Pro Val His Phe Arg Pro Ile Tyr Arg Gly Ala 
    370                 375                 380                 


Ser Ala Ala Phe Cys Ile Gln Leu Phe Cys Ile Asp Glu Lys Tyr Glu 
385                 390                 395                 400 


Ala Arg Ser Leu Asp Phe Met Asn Phe Val Phe Ser Leu Phe Ser Asp 
                405                 410                 415     


Lys Asn Phe Cys Val Ile Ser Leu Pro His Leu Thr Pro Glu Phe Phe 
            420                 425                 430         


Leu Ile Gln Asn Phe Val Lys Met Val Pro Phe Asn Thr Cys Thr Leu 
        435                 440                 445             


Glu Gln Asp Leu Tyr Val Phe His Arg Ala Gly Leu Leu Lys Asn Ile 
    450                 455                 460                 


Cys Leu Gly Arg Ser Ser 
465                 470 


<210>  2198
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  2198

Met Tyr Cys Leu Gln Trp Leu Leu Pro Val Leu Leu Ile Pro Lys Pro 
1               5                   10                  15      


Leu Asn Pro Ala Leu Trp Phe Ser His Ser Met Phe Met Gly Phe Tyr 
            20                  25                  30          


Leu Leu Ser Phe Leu Leu Glu Arg Lys Pro Cys Thr Ile Cys Ala Leu 
        35                  40                  45              


Val Phe Leu Ala Ala Leu Phe Leu Ile Cys Tyr Ser Cys Trp Gly Asn 
    50                  55                  60                  


Cys Phe Leu Tyr His Cys Ser Asp Ser Pro Leu Pro Glu Ser Ala His 
65                  70                  75                  80  


Asp Pro Gly Val Val Gly Thr 
                85          


<210>  2199
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  2199

Met Tyr Cys Leu Gln Trp Leu Leu Pro Val Leu Leu Ile Pro Lys Pro 
1               5                   10                  15      


Leu Asn Pro Ala Leu Trp Phe Ser His Ser Met Phe Met Gly Phe Tyr 
            20                  25                  30          


Leu Leu Ser Phe Leu Leu Glu Arg Lys Pro Cys Thr Ile Cys Ala Leu 
        35                  40                  45              


Val Phe Leu Ala Ala Leu Phe Leu Ile Cys Tyr Ser Cys Trp Gly Asn 
    50                  55                  60                  


Cys Phe Leu Tyr His Cys Ser Asp Ser Pro Leu Pro Glu Ser Ala His 
65                  70                  75                  80  


Asp Pro Gly Val Val Gly Thr 
                85          


<210>  2200
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  2200

Met Tyr Cys Leu Gln Trp Leu Leu Pro Val Leu Leu Ile Pro Lys Pro 
1               5                   10                  15      


Leu Asn Pro Ala Leu Trp Phe Ser His Ser Met Phe Met Gly Phe Tyr 
            20                  25                  30          


Leu Leu Ser Phe Leu Leu Glu Arg Lys Pro Cys Thr Ile Cys Ala Leu 
        35                  40                  45              


Val Phe Leu Ala Ala Leu Phe Leu Ile Cys Tyr Ser Cys Trp Gly Asn 
    50                  55                  60                  


Cys Phe Leu Tyr His Cys Ser Asp Ser Pro Leu Pro Glu Ser Ala His 
65                  70                  75                  80  


Asp Pro Gly Val Val Gly Thr 
                85          


<210>  2201
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  2201

Met Tyr Cys Leu Gln Trp Leu Leu Pro Val Leu Leu Ile Pro Lys Pro 
1               5                   10                  15      


Leu Asn Pro Ala Leu Trp Phe Ser His Ser Met Phe Met Gly Phe Tyr 
            20                  25                  30          


Leu Leu Ser Phe Leu Leu Glu Arg Lys Pro Cys Thr Ile Cys Ala Leu 
        35                  40                  45              


Val Phe Leu Ala Ala Leu Phe Leu Ile Cys Tyr Ser Cys Trp Gly Asn 
    50                  55                  60                  


Cys Phe Leu Tyr His Cys Ser Asp Ser Pro Leu Pro Glu Ser Ala His 
65                  70                  75                  80  


Asp Pro Gly Val Val Gly Thr 
                85          


<210>  2202
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  2202

Met Gly Asp Lys Ile Trp Leu Pro Phe Pro Val Leu Leu Leu Ala Ala 
1               5                   10                  15      


Leu Pro Pro Val Leu Leu Pro Gly Ala Ala Gly Phe Thr Pro Ser Leu 
            20                  25                  30          


Asp Ser Asp Phe Thr Phe Thr Leu Pro Ala Gly Gln Lys Glu Cys Phe 
        35                  40                  45              


Tyr Gln Pro Met Pro Leu Lys Ala Ser Leu Glu Ile Glu Tyr Gln Val 
    50                  55                  60                  


Leu Asp Gly Ala Gly Leu Asp Ile Asp Phe His Leu Ala Ser Pro Glu 
65                  70                  75                  80  


Gly Lys Thr Leu Val Phe Glu Gln Arg Lys Ser Asp Gly Val His Thr 
                85                  90                  95      


Val Glu Thr Glu Val Gly Asp Tyr Met Phe Cys Phe Asp Asn Thr Phe 
            100                 105                 110         


Ser Thr Ile Ser Glu Lys Val Ile Phe Phe Glu Leu Ile Leu Asp Asn 
        115                 120                 125             


Met Gly Glu Gln Ala Gln Glu Gln Glu Asp Trp Lys Lys Tyr Ile Thr 
    130                 135                 140                 


Gly Thr Asp Ile Leu Asp Met Lys Leu Glu Asp Ile Leu Asp Pro Ile 
145                 150                 155                 160 


Ile Lys Ile Ala Ser Asp Val Gln Ile Arg Leu His Leu Gly Ile His 
                165                 170                 175     


Gln Gln His Gln Val Gln Thr Lys Gln Lys Trp Ala His Thr Asn Ser 
            180                 185                 190         


Ala 
    


<210>  2203
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  2203

Met Gly Val Ala Leu Arg Asp Leu Pro Gly Arg His Val Ser Ser Arg 
1               5                   10                  15      


Ser His Val Thr Ala Val Leu Thr Val Phe His Gly Arg Cys Phe Leu 
            20                  25                  30          


Pro Gly Phe Gly Val Val Thr Thr Phe Pro Ser Pro Ser Pro Ala Gly 
        35                  40                  45              


Ala Met Glu Glu Glu Asp Glu Glu Ala Arg Ala Leu Leu Ala Gly Gly 
    50                  55                  60                  


Pro Asp Glu Ala Asp Arg Gly Ala Pro Ala Ala Pro Gly Ala Leu Pro 
65                  70                  75                  80  


Ala Leu Cys Asp Pro Ser Arg Leu Ala His Arg Leu Leu Val Leu Leu 
                85                  90                  95      


Leu Met Cys Phe Leu Gly Phe Ala Ile Phe Ala Met Ile Ile Leu Leu 
            100                 105                 110         


Pro Phe Arg Leu Lys Leu Asn Glu Trp Gly Thr Ile Ile Phe Ser Cys 
        115                 120                 125             


Phe Val Cys Ile Gly Gln Val Val Phe Ala Leu Gly Gly Ile Phe Asn 
    130                 135                 140                 


Ala Phe Trp Leu Met Glu Phe Gly Arg Phe Val Phe Gly Ile Gly Gly 
145                 150                 155                 160 


Glu Ser Leu Ala Val Ala Gln Asn Thr Tyr Ala Val Ser Trp Phe Lys 
                165                 170                 175     


Gly Lys Glu Leu Asn Leu Val Phe Gly Leu Gln Leu Ser Met Ala Arg 
            180                 185                 190         


Ile Gly Ser Thr Val Asn Met Asn Leu Met Gly Trp Leu Tyr Ser Lys 
        195                 200                 205             


Ile Glu Ala Leu Leu Gly Ser Ala Gly His Thr Thr Leu Gly Ile Thr 
    210                 215                 220                 


Leu Met Ile Gly Gly Ile Thr Cys Ile Leu Ser Leu Ile Cys Ala Leu 
225                 230                 235                 240 


Ala Leu Ala Tyr Leu Asp Gln Arg Ala Glu Arg Ile Leu His Lys Glu 
                245                 250                 255     


Gln Gly Lys Thr Gly Glu Val Ile Lys Leu Thr Asp Val Lys Asp Phe 
            260                 265                 270         


Ser Leu Pro Leu Trp Leu Ile Phe Ile Ile Cys Val Cys Tyr Tyr Val 
        275                 280                 285             


Ala Val Phe Pro Phe Ile Gly Leu Gly Lys Val Phe Phe Thr Glu Lys 
    290                 295                 300                 


Phe Gly Phe Ser Ser Gln Ala Ala Ser Ala Ile Asn Ser Val Val Tyr 
305                 310                 315                 320 


Val Ile Ser Ala Pro Met Ser Pro Val Phe Gly Leu Leu Val Asp Lys 
                325                 330                 335     


Thr Gly Lys Asn Ile Ile Trp Val Leu Cys Ala Val Ala Ala Thr Leu 
            340                 345                 350         


Val Ser His Met Met Leu Ala Phe Thr Met Trp Asn Pro Trp Ile Ala 
        355                 360                 365             


Met Cys Leu Leu Gly Leu Ser Tyr Ser Leu Leu Ala Cys Ala Leu Trp 
    370                 375                 380                 


Pro Met Val Ala Phe Val Val Pro Glu His Gln Leu Gly Thr Ala Tyr 
385                 390                 395                 400 


Gly Phe Met Gln Ser Ile Gln Asn Leu Gly Leu Ala Ile Ile Ser Ile 
                405                 410                 415     


Ile Ala Gly Met Ile Leu Asp Ser Arg Gly Tyr Leu Phe Leu Glu Val 
            420                 425                 430         


Phe Phe Ile Ala Cys Val Ser Leu Ser Leu Leu Ser Val Val Leu Leu 
        435                 440                 445             


Tyr Leu Val Asn Arg Ala Gln Gly Gly Asn Leu Asn Tyr Ser Ala Arg 
    450                 455                 460                 


Gln Arg Glu Glu Ile Lys Phe Ser His Thr Glu 
465                 470                 475 


<210>  2204
<211>  570
<212>  PRT
<213>  Homo sapiens

<400>  2204

Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu 
1               5                   10                  15      


Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met 
            20                  25                  30          


Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro 
        35                  40                  45              


Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala 
    50                  55                  60                  


Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu 
65                  70                  75                  80  


Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys 
                85                  90                  95      


Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro 
        115                 120                 125             


Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu 
    130                 135                 140                 


Pro Val His Lys Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys 
145                 150                 155                 160 


Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr 
                165                 170                 175     


Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro 
            180                 185                 190         


Glu Gly Met Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly 
        195                 200                 205             


Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His 
    210                 215                 220                 


Leu Thr Arg Thr Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala 
225                 230                 235                 240 


Val Pro Pro Val Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys 
                245                 250                 255     


Glu Pro Gly Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe 
            260                 265                 270         


Leu Met Asp Ser Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys 
        275                 280                 285             


Pro Asp Asp Ile Thr Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His 
    290                 295                 300                 


Ser Arg Thr Glu Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys 
305                 310                 315                 320 


Val Thr Ser Glu Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser 
                325                 330                 335     


Ala Lys Gly Glu Val Ala Lys Ala Ala Lys Val Lys Gln Lys Val Pro 
            340                 345                 350         


Ala Pro Arg Tyr Thr Val Glu Leu Ala Cys Gly Phe Gly Ala Thr Val 
        355                 360                 365             


Leu Leu Val Val Ile Leu Ile Val Val Tyr His Val Tyr Trp Leu Glu 
    370                 375                 380                 


Met Val Leu Phe Tyr Arg Ala His Phe Gly Thr Asp Glu Thr Ile Leu 
385                 390                 395                 400 


Asp Gly Lys Glu Tyr Asp Ile Tyr Val Ser Tyr Ala Arg Asn Ala Glu 
                405                 410                 415     


Glu Glu Glu Phe Val Leu Leu Thr Leu Arg Gly Val Leu Glu Asn Glu 
            420                 425                 430         


Phe Gly Tyr Lys Leu Cys Ile Phe Asp Arg Asp Ser Leu Pro Gly Gly 
        435                 440                 445             


Ile Val Thr Asp Glu Thr Leu Ser Phe Ile Gln Lys Ser Arg Arg Leu 
    450                 455                 460                 


Leu Val Val Leu Ser Pro Asn Tyr Val Leu Gln Gly Thr Gln Ala Leu 
465                 470                 475                 480 


Leu Glu Leu Lys Ala Gly Leu Glu Asn Met Ala Ser Arg Gly Asn Ile 
                485                 490                 495     


Asn Val Ile Leu Val Gln Tyr Lys Ala Val Lys Glu Thr Lys Val Lys 
            500                 505                 510         


Glu Leu Lys Arg Ala Lys Thr Val Leu Thr Val Ile Lys Trp Lys Gly 
        515                 520                 525             


Glu Lys Ser Lys Tyr Pro Gln Gly Arg Phe Trp Lys Gln Leu Gln Val 
    530                 535                 540                 


Ala Met Pro Val Lys Lys Ser Pro Arg Arg Ser Ser Ser Asp Glu Gln 
545                 550                 555                 560 


Gly Leu Ser Tyr Ser Ser Leu Lys Asn Val 
                565                 570 


<210>  2205
<211>  570
<212>  PRT
<213>  Homo sapiens

<400>  2205

Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu 
1               5                   10                  15      


Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met 
            20                  25                  30          


Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro 
        35                  40                  45              


Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala 
    50                  55                  60                  


Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu 
65                  70                  75                  80  


Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys 
                85                  90                  95      


Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro 
        115                 120                 125             


Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu 
    130                 135                 140                 


Pro Val His Lys Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys 
145                 150                 155                 160 


Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr 
                165                 170                 175     


Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro 
            180                 185                 190         


Glu Gly Met Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly 
        195                 200                 205             


Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His 
    210                 215                 220                 


Leu Thr Arg Thr Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala 
225                 230                 235                 240 


Val Pro Pro Val Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys 
                245                 250                 255     


Glu Pro Gly Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe 
            260                 265                 270         


Leu Met Asp Ser Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys 
        275                 280                 285             


Pro Asp Asp Ile Thr Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His 
    290                 295                 300                 


Ser Arg Thr Glu Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys 
305                 310                 315                 320 


Val Thr Ser Glu Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser 
                325                 330                 335     


Ala Lys Gly Glu Val Ala Lys Ala Ala Lys Val Lys Gln Lys Val Pro 
            340                 345                 350         


Ala Pro Arg Tyr Thr Val Glu Leu Ala Cys Gly Phe Gly Ala Thr Val 
        355                 360                 365             


Leu Leu Val Val Ile Leu Ile Val Val Tyr His Val Tyr Trp Leu Glu 
    370                 375                 380                 


Met Val Leu Phe Tyr Arg Ala His Phe Gly Thr Asp Glu Thr Ile Leu 
385                 390                 395                 400 


Asp Gly Lys Glu Tyr Asp Ile Tyr Val Ser Tyr Ala Arg Asn Ala Glu 
                405                 410                 415     


Glu Glu Glu Phe Val Leu Leu Thr Leu Arg Gly Val Leu Glu Asn Glu 
            420                 425                 430         


Phe Gly Tyr Lys Leu Cys Ile Phe Asp Arg Asp Ser Leu Pro Gly Gly 
        435                 440                 445             


Ile Val Thr Asp Glu Thr Leu Ser Phe Ile Gln Lys Ser Arg Arg Leu 
    450                 455                 460                 


Leu Val Val Leu Ser Pro Asn Tyr Val Leu Gln Gly Thr Gln Ala Leu 
465                 470                 475                 480 


Leu Glu Leu Lys Ala Gly Leu Glu Asn Met Ala Ser Arg Gly Asn Ile 
                485                 490                 495     


Asn Val Ile Leu Val Gln Tyr Lys Ala Val Lys Glu Thr Lys Val Lys 
            500                 505                 510         


Glu Leu Lys Arg Ala Lys Thr Val Leu Thr Val Ile Lys Trp Lys Gly 
        515                 520                 525             


Glu Lys Ser Lys Tyr Pro Gln Gly Arg Phe Trp Lys Gln Leu Gln Val 
    530                 535                 540                 


Ala Met Pro Val Lys Lys Ser Pro Arg Arg Ser Ser Ser Asp Glu Gln 
545                 550                 555                 560 


Gly Leu Ser Tyr Ser Ser Leu Lys Asn Val 
                565                 570 


<210>  2206
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  2206

Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu 
1               5                   10                  15      


Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met 
            20                  25                  30          


Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro 
        35                  40                  45              


Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala 
    50                  55                  60                  


Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu 
65                  70                  75                  80  


Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys 
                85                  90                  95      


Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro 
        115                 120                 125             


Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu 
    130                 135                 140                 


Pro Val His Lys Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys 
145                 150                 155                 160 


Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr 
                165                 170                 175     


Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro 
            180                 185                 190         


Glu Gly Met Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly 
        195                 200                 205             


Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His 
    210                 215                 220                 


Leu Thr Arg Thr Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala 
225                 230                 235                 240 


Val Pro Pro Val Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys 
                245                 250                 255     


Glu Pro Gly Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe 
            260                 265                 270         


Leu Met Asp Ser Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys 
        275                 280                 285             


Pro Asp Asp Ile Thr Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His 
    290                 295                 300                 


Ser Arg Thr Glu Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys 
305                 310                 315                 320 


Val Thr Ser Glu Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser 
                325                 330                 335     


Ala Lys Gly Glu Val Ala Lys Ala Ala Lys Val Lys Gln Lys Gly Asn 
            340                 345                 350         


Arg Cys Gly Gln 
        355     


<210>  2207
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  2207

Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu 
1               5                   10                  15      


Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met 
            20                  25                  30          


Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro 
        35                  40                  45              


Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala 
    50                  55                  60                  


Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu 
65                  70                  75                  80  


Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys 
                85                  90                  95      


Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro 
        115                 120                 125             


Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu 
    130                 135                 140                 


Pro Val His Lys Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys 
145                 150                 155                 160 


Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr 
                165                 170                 175     


Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro 
            180                 185                 190         


Glu Gly Met Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly 
        195                 200                 205             


Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His 
    210                 215                 220                 


Leu Thr Arg Thr Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala 
225                 230                 235                 240 


Val Pro Pro Val Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys 
                245                 250                 255     


Glu Pro Gly Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe 
            260                 265                 270         


Leu Met Asp Ser Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys 
        275                 280                 285             


Pro Asp Asp Ile Thr Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His 
    290                 295                 300                 


Ser Arg Thr Glu Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys 
305                 310                 315                 320 


Val Thr Ser Glu Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser 
                325                 330                 335     


Ala Lys Gly Glu Val Ala Lys Ala Ala Lys Val Lys Gln Lys Val Pro 
            340                 345                 350         


Ala Pro Arg Tyr Thr Val Glu Leu Ala Cys Gly Phe Gly Ala Thr Val 
        355                 360                 365             


Leu Leu Val Val Ile Leu Ile Val Val Tyr His Val Tyr Trp Leu Glu 
    370                 375                 380                 


Met Val Leu Phe Tyr Arg Ala His Phe Gly Thr Asp Glu Thr Ile Leu 
385                 390                 395                 400 


Asp Gly Lys Glu Tyr Asp Ile Tyr Val Ser Tyr Ala Arg Asn Ala Glu 
                405                 410                 415     


Glu Glu Glu Phe Val Leu Leu Thr Leu Arg Gly Val Leu Glu Asn Glu 
            420                 425                 430         


Phe Gly Tyr Lys Leu Cys Ile Phe Asp Arg Asp Ser Leu Pro Gly Gly 
        435                 440                 445             


Asn Thr Val Glu Ala Val Phe Asp Phe Ile Gln Arg Ser Arg Arg Met 
    450                 455                 460                 


Ile Val Val Leu Ser Pro Asp Tyr Val Thr Glu Lys Ser Ile Ser Met 
465                 470                 475                 480 


Leu Glu Phe Lys Leu Gly Val Met Cys Gln Asn Ser Ile Ala Thr Lys 
                485                 490                 495     


Leu Ile Val Val Glu Tyr Arg Pro Leu Glu His Pro His Pro Gly Ile 
            500                 505                 510         


Leu Gln Leu Lys Glu Ser Val Ser Phe Val Ser Trp Lys Gly Glu Lys 
        515                 520                 525             


Ser Lys His Ser Gly Ser Lys Phe Trp Lys Ala Leu Arg Leu Ala Leu 
    530                 535                 540                 


Pro Leu Arg Ser Leu Ser Ala Ser Ser Gly Trp Asn Glu Ser Cys Ser 
545                 550                 555                 560 


Ser Gln Ser Asp Ile Ser Leu Asp His Val Gln Arg Arg Arg Ser Arg 
                565                 570                 575     


Leu Lys Glu Pro Pro Glu Leu Gln Ser Ser Glu Arg Ala Ala Gly Ser 
            580                 585                 590         


Pro Pro Ala Pro Gly Thr Met Ser Lys His Arg Gly Lys Ser Ser Ala 
        595                 600                 605             


Thr Cys Arg Cys Cys Val Thr Tyr Cys Glu Gly Glu Asn His Leu Arg 
    610                 615                 620                 


Asn Lys Ser Arg Ala Glu Ile His Asn Gln Pro Gln Trp Glu Thr His 
625                 630                 635                 640 


Leu Cys Lys Pro Val Pro Gln Glu Ser Glu Thr Gln Trp Ile Gln Asn 
                645                 650                 655     


Gly Thr Arg Leu Glu Pro Pro Ala Pro Gln Ile Ser Ala Leu Ala Leu 
            660                 665                 670         


His His Phe Thr Asp Leu Ser Asn Asn Asn Asp Phe Tyr Ile Leu 
        675                 680                 685         


<210>  2208
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  2208

Met Glu Glu Tyr Ala Arg Glu Pro Cys Pro Trp Arg Ile Val Asp Asp 
1               5                   10                  15      


Cys Gly Gly Ala Phe Thr Met Gly Val Ile Gly Gly Gly Val Phe Gln 
            20                  25                  30          


Ala Ile Lys Gly Phe Arg Asn Ala Pro Val Cys Arg Leu Leu Ser Glu 
        35                  40                  45              


Ala Pro Leu Phe Ile Tyr Ser Cys Ser Arg Ser Val Ser Pro Thr Val 
    50                  55                  60                  


Asn Val Ser Ser Glu Arg Ala Glu Ser Arg Pro Thr Leu Phe Met Ala 
65                  70                  75                  80  


Val Ser Leu His Met Ala Trp Cys Leu Ala His Ile Gly Ile Arg His 
                85                  90                  95      


Arg Leu Arg Gly Ser Ala Asn Ala Val Arg Ile Arg Ala Pro Gln Ile 
            100                 105                 110         


Gly Gly Ser Phe Ala Val Trp Gly Gly Leu Phe Ser Thr Ile Asp Cys 
        115                 120                 125             


Gly Leu Val Arg Leu Arg Gly Lys Glu Asp Pro Trp Asn Ser Ile Thr 
    130                 135                 140                 


Ser Gly Ala Leu Thr Gly Ala Val Leu Ala Ala Arg Ser Gly Pro Leu 
145                 150                 155                 160 


Ala Met Val Gly Ser Ala Met Met Gly Gly Ile Leu Leu Ala Leu Ile 
                165                 170                 175     


Glu Gly Val Gly Ile Leu Leu Thr Arg Tyr Thr Ala Gln Gln Phe Arg 
            180                 185                 190         


Asn Ala Pro Pro Phe Leu Glu Asp Pro Ser Gln Leu Pro Pro Lys Asp 
        195                 200                 205             


Gly Thr Pro Ala Pro Gly Tyr Pro Ser Tyr Gln Gln Tyr His 
    210                 215                 220         


<210>  2209
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  2209

Met Ala Val Ala Val Leu Leu Cys Gly Cys Ile Val Ala Thr Val Ser 
1               5                   10                  15      


Phe Phe Trp Glu Glu Ser Leu Thr Gln His Val Ala Gly Leu Leu Phe 
            20                  25                  30          


Leu Met Thr Gly Ile Phe Cys Thr Ile Ser Leu Cys Thr Tyr Ala Ala 
        35                  40                  45              


Ser Ile Ser Tyr Asp Leu Asn Arg Leu Pro Lys Leu Ile Tyr Ser Leu 
    50                  55                  60                  


Pro Ala Asp Val Glu His Gly Tyr Ser Trp Ser Ile Phe Cys Ala Trp 
65                  70                  75                  80  


Cys Ser Leu Gly Phe Ile Val Ala Ala Gly Gly Leu Cys Ile Ala Tyr 
                85                  90                  95      


Pro Phe Ile Ser Arg Thr Lys Ile Ala Gln Leu Lys Ser Gly Arg Asp 
            100                 105                 110         


Ser Thr Val 
        115 


<210>  2210
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  2210

Met Trp Gly Pro Gly Val Thr Ala Glu Gly Leu Ser Val Ala Pro Ala 
1               5                   10                  15      


Pro Pro Pro Leu Leu Pro Leu Leu Leu Leu Leu Ala Leu Ala Leu Val 
            20                  25                  30          


Ala Pro Ser Arg Gly Gly Gly Gly Cys Ala Glu Leu Ala Cys Gly Glu 
        35                  40                  45              


Arg Glu Arg Cys Cys Asp Ala Thr Asn Ala Thr Ala Val Arg Cys Cys 
    50                  55                  60                  


Lys Leu Pro Leu His Ala Phe Leu Asp Asn Val Gly Trp Phe Val Arg 
65                  70                  75                  80  


Lys Leu Ser Gly Leu Leu Ile Leu Leu Val Leu Phe Ala Ile Gly Tyr 
                85                  90                  95      


Phe Leu Gln Arg Ile Ile Cys Pro Ser Pro Arg Arg Tyr Pro Arg Gly 
            100                 105                 110         


Gln Ala Arg Pro Gly Gln Arg Pro Gly Pro Pro Gly Gly Ala Gly Pro 
        115                 120                 125             


Leu Gly Gly Ala Gly Pro Pro Asp Asp Asp Asp Asp Ser Pro Ala Leu 
    130                 135                 140                 


Leu Arg Asp Glu Ala Ala Ala Gly Ser Gln Asp Ser Leu Leu Asp Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Arg Gly Arg Gly Gly Gly Gly Arg Ser Asp Pro Ser 
                165                 170                 175     


Cys Ala Ser Glu His Glu Met Arg Val Val Ser Pro Val Phe Leu Gln 
            180                 185                 190         


Leu Pro Ser Tyr Glu Glu Val Lys Tyr Leu Pro Thr Tyr Glu Glu Ser 
        195                 200                 205             


Met Arg Leu Gln Gln Leu Ser Pro Gly Glu Val Val Leu Pro Val Ser 
    210                 215                 220                 


Val Leu Gly Arg Pro Arg Gly Gly Val Ala Ala Glu Pro Asp Gly Gly 
225                 230                 235                 240 


Glu Gly Arg Tyr Pro Leu Ile 
                245         


<210>  2211
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  2211

Met Ser Gln Ala Trp Val Pro Gly Leu Ala Pro Thr Leu Leu Phe Ser 
1               5                   10                  15      


Leu Leu Ala Gly Pro Gln Lys Ile Ala Ala Lys Cys Gly Leu Ile Leu 
            20                  25                  30          


Ala Cys Pro Lys Gly Phe Lys Cys Cys Gly Asp Ser Cys Cys Gln Glu 
        35                  40                  45              


Asn Glu Leu Phe Pro Gly Pro Val Arg Ile Phe Val Ile Ile Phe Leu 
    50                  55                  60                  


Val Ile Leu Ser Val Phe Cys Ile Cys Gly Leu Ala Lys Cys Phe Cys 
65                  70                  75                  80  


Arg Asn Cys Arg Glu Pro Glu Pro Asp Ser Pro Val Asp Cys Arg Gly 
                85                  90                  95      


Pro Leu Glu Leu Pro Ser Ile Ile Pro Pro Glu Arg Val Arg Val Ser 
            100                 105                 110         


Leu Ser Ala Pro Pro Pro Pro Tyr Ser Glu Val Ile Leu Lys Pro Ser 
        115                 120                 125             


Leu Gly Pro Thr Pro Thr Glu Pro Pro Pro Pro Tyr Ser Phe Arg Pro 
    130                 135                 140                 


Glu Glu Tyr Thr Gly Asp Gln Arg Gly Ile Asp Asn Pro Ala Phe 
145                 150                 155                 


<210>  2212
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  2212

Met Glu Cys Gly Lys Met Asn Gly Arg Ala Asp Phe Arg Glu Pro Asn 
1               5                   10                  15      


Ala Glu Val Pro Arg Pro Ile Pro His Ile Gly Pro Asp Tyr Ile Pro 
            20                  25                  30          


Thr Glu Glu Glu Arg Arg Val Phe Ala Glu Cys Asn Asp Glu Ser Phe 
        35                  40                  45              


Trp Phe Arg Ser Val Pro Leu Ala Ala Thr Ser Met Leu Ile Thr Gln 
    50                  55                  60                  


Gly Leu Ile Ser Lys Gly Ile Leu Ser Ser His Pro Lys Tyr Gly Ser 
65                  70                  75                  80  


Ile Pro Lys Leu Ile Leu Ala Cys Ile Met Gly Tyr Phe Ala Gly Lys 
                85                  90                  95      


Leu Ser Tyr Val Lys Thr Cys Gln Glu Lys Phe Lys Lys Leu Glu Asn 
            100                 105                 110         


Ser Pro Leu Gly Glu Ala Leu Arg Ser Gly Gln Ala Arg Arg Ser Ser 
        115                 120                 125             


Pro Pro Gly His Tyr Tyr Gln Lys Ser Lys Tyr Asp Ser Ser Val Ser 
    130                 135                 140                 


Gly Gln Ser Ser Phe Val Thr Ser Pro Ala Ala Asp Asn Ile Glu Met 
145                 150                 155                 160 


Leu Pro His Tyr Glu Pro Ile Pro Phe Ser Ser Ser Met Asn Glu Ser 
                165                 170                 175     


Ala Pro Thr Gly Ile Thr Asp His Ile Val Gln Gly Pro Asp Pro Asn 
            180                 185                 190         


Leu Glu Glu Ser Pro Lys Arg Lys Asn Ile Thr Tyr Glu Glu Leu Arg 
        195                 200                 205             


Asn Lys Asn Arg Glu Ser Tyr Glu Val Ser Leu Thr Gln Lys Thr Asp 
    210                 215                 220                 


Pro Ser Val Arg Pro Met His Glu Arg Val Pro Lys Lys Glu Val Lys 
225                 230                 235                 240 


Val Asn Lys Tyr Gly Asp Thr Trp Asp Glu 
                245                 250 


<210>  2213
<211>  810
<212>  PRT
<213>  Homo sapiens

<400>  2213

Met Glu Pro Glu Ile Asn Cys Ser Glu Leu Cys Asp Ser Phe Pro Gly 
1               5                   10                  15      


Gln Glu Leu Asp Arg Arg Pro Leu His Asp Leu Cys Lys Thr Thr Ile 
            20                  25                  30          


Thr Ser Ser His His Ser Ser Lys Thr Ile Ser Ser Leu Ser Pro Val 
        35                  40                  45              


Leu Leu Gly Ile Val Trp Thr Phe Leu Ser Cys Gly Leu Leu Leu Ile 
    50                  55                  60                  


Leu Phe Phe Leu Ala Phe Thr Ile His Cys Arg Lys Asn Arg Ile Val 
65                  70                  75                  80  


Lys Met Ser Ser Pro Asn Leu Asn Ile Val Thr Leu Leu Gly Ser Cys 
                85                  90                  95      


Leu Thr Tyr Ser Ser Ala Tyr Leu Phe Gly Ile Gln Asp Val Leu Val 
            100                 105                 110         


Gly Ser Ser Met Glu Thr Leu Ile Gln Thr Arg Leu Ser Met Leu Cys 
        115                 120                 125             


Ile Gly Thr Ser Leu Val Phe Gly Pro Ile Leu Gly Lys Ser Trp Arg 
    130                 135                 140                 


Leu Tyr Lys Val Phe Thr Gln Arg Val Pro Asp Lys Arg Val Ile Ile 
145                 150                 155                 160 


Lys Asp Leu Gln Leu Leu Gly Leu Val Ala Ala Leu Leu Met Ala Asp 
                165                 170                 175     


Val Ile Leu Leu Met Thr Trp Val Leu Thr Asp Pro Ile Gln Cys Leu 
            180                 185                 190         


Gln Ile Leu Ser Val Thr Gly Lys Asp Val Ser Cys Thr Ser Thr Ser 
        195                 200                 205             


Thr His Phe Cys Ala Ser Arg Tyr Ser Asp Val Trp Ile Ala Leu Ile 
    210                 215                 220                 


Trp Gly Cys Lys Gly Leu Leu Leu Leu Tyr Gly Ala Tyr Leu Ala Gly 
225                 230                 235                 240 


Leu Thr Gly His Val Ser Ser Pro Pro Val Asn Gln Ser Leu Thr Ile 
                245                 250                 255     


Met Val Gly Val Asn Leu Leu Val Leu Ala Ala Gly Leu Leu Phe Val 
            260                 265                 270         


Val Thr Arg Tyr Leu His Ser Trp Pro Asn Leu Val Phe Gly Leu Thr 
        275                 280                 285             


Ser Gly Gly Ile Phe Val Cys Thr Thr Thr Ile Asn Cys Phe Ile Phe 
    290                 295                 300                 


Ile Pro Gln Leu Lys Gln Trp Lys Ala Phe Glu Glu Glu Asn Gln Thr 
305                 310                 315                 320 


Ile Arg Arg Met Ala Lys Tyr Phe Ser Thr Pro Asn Lys Ser Phe His 
                325                 330                 335     


Thr Gln Tyr Gly Glu Glu Glu Asn Cys His Pro Arg Gly Glu Lys Ser 
            340                 345                 350         


Ser Met Glu Arg Leu Leu Thr Glu Lys Asn Ala Val Ile Glu Ser Leu 
        355                 360                 365             


Gln Glu Gln Val Asn Asn Ala Lys Glu Lys Ile Val Arg Leu Met Ser 
    370                 375                 380                 


Ala Glu Cys Thr Tyr Asp Leu Pro Glu Gly Ala Ala Pro Pro Ala Ser 
385                 390                 395                 400 


Ser Pro Asn Lys Asp Val Gln Ala Val Ala Ser Val His Thr Leu Ala 
                405                 410                 415     


Ala Ala Gln Gly Pro Ser Gly His Leu Ser Asp Phe Gln Asn Asp Pro 
            420                 425                 430         


Gly Met Ala Ala Arg Asp Ser Gln Cys Thr Ser Gly Pro Ser Ser Tyr 
        435                 440                 445             


Ala Gln Ser Leu Glu Gly Pro Gly Lys Asp Ser Ser Phe Ser Pro Gly 
    450                 455                 460                 


Lys Glu Glu Lys Ile Ser Asp Ser Lys Asp Phe Ser Asp His Leu Asp 
465                 470                 475                 480 


Ser Gly Cys Ser Gln Lys Pro Trp Thr Glu Gln Ser Leu Gly Pro Glu 
                485                 490                 495     


Arg Gly Asp Gln Val Pro Met Asn Pro Ser Gln Ser Leu Leu Pro Glu 
            500                 505                 510         


Arg Gly Gly Ser Asp Pro Gln Arg Gln Arg His Leu Glu Asn Ser Glu 
        515                 520                 525             


Glu Pro Pro Glu Arg Arg Ser Arg Val Ser Ser Val Ile Arg Glu Lys 
    530                 535                 540                 


Leu Gln Glu Val Leu Gln Asp Leu Gly Leu Gly Pro Glu Ala Ser Leu 
545                 550                 555                 560 


Ser Thr Ala Pro Ser Cys His Gln Gln Thr Trp Lys Asn Ser Ala Ala 
                565                 570                 575     


Phe Ser Pro Gln Lys Met Pro Leu Ser Lys Glu Leu Gly Phe Ser Pro 
            580                 585                 590         


Tyr Met Val Arg Arg Arg Arg Ala Ala Gln Arg Ala Arg Ser His Phe 
        595                 600                 605             


Pro Gly Ser Ala Pro Ser Ser Val Gly His Arg Ala Asn Arg Thr Val 
    610                 615                 620                 


Pro Gly Ala His Ser Arg Leu His Val Gln Asn Gly Asp Ser Pro Ser 
625                 630                 635                 640 


Leu Ala Pro Gln Thr Thr Asp Ser Arg Val Arg Arg Pro Ser Ser Arg 
                645                 650                 655     


Lys Pro Ser Leu Pro Ser Asp Pro Gln Asp Arg Pro Gly Thr Leu Glu 
            660                 665                 670         


Gly Ser Lys Gln Ser Gln Thr Glu Pro Glu Gly Ala Arg Gly Ser Lys 
        675                 680                 685             


Ala Ala Phe Leu Arg Gln Pro Ser Gly Ser Gly Arg Ala Pro Ser Pro 
    690                 695                 700                 


Ala Ala Pro Cys Leu Ser Lys Ala Ser Pro Asp Leu Pro Glu Gln Trp 
705                 710                 715                 720 


Gln Leu Trp Pro Pro Val Pro Ser Gly Cys Ala Ser Leu Ser Ser Gln 
                725                 730                 735     


His Ser Tyr Phe Asp Thr Glu Ser Ser Ser Ser Asp Glu Phe Phe Cys 
            740                 745                 750         


Arg Cys His Arg Pro Tyr Cys Glu Ile Cys Phe Gln Ser Ser Ser Asp 
        755                 760                 765             


Ser Ser Asp Ser Gly Thr Ser Asp Thr Asp Pro Glu Pro Thr Gly Gly 
    770                 775                 780                 


Leu Ala Ser Trp Glu Lys Leu Trp Ala Arg Ser Lys Pro Ile Val Asn 
785                 790                 795                 800 


Phe Lys Asp Asp Leu Lys Pro Thr Leu Val 
                805                 810 


<210>  2214
<211>  2743
<212>  PRT
<213>  Homo sapiens

<400>  2214

Met Ser Asp Lys Met Ser Ser Phe Leu His Ile Gly Asp Ile Cys Ser 
1               5                   10                  15      


Leu Tyr Ala Glu Gly Ser Thr Asn Gly Phe Ile Ser Thr Leu Gly Leu 
            20                  25                  30          


Val Asp Asp Arg Cys Val Val Gln Pro Glu Thr Gly Asp Leu Asn Asn 
        35                  40                  45              


Pro Pro Lys Lys Phe Arg Asp Cys Leu Phe Lys Leu Cys Pro Met Asn 
    50                  55                  60                  


Arg Tyr Ser Ala Gln Lys Gln Phe Trp Lys Ala Ala Lys Pro Gly Ala 
65                  70                  75                  80  


Asn Ser Thr Thr Asp Ala Val Leu Leu Asn Lys Leu His His Ala Ala 
                85                  90                  95      


Asp Leu Glu Lys Lys Gln Asn Glu Thr Glu Asn Arg Lys Leu Leu Gly 
            100                 105                 110         


Thr Val Ile Gln Tyr Gly Asn Val Ile Gln Leu Leu His Leu Lys Ser 
        115                 120                 125             


Asn Lys Tyr Leu Thr Val Asn Lys Arg Leu Pro Ala Leu Leu Glu Lys 
    130                 135                 140                 


Asn Ala Met Arg Val Thr Leu Asp Glu Ala Gly Asn Glu Gly Ser Trp 
145                 150                 155                 160 


Phe Tyr Ile Gln Pro Phe Tyr Lys Leu Arg Ser Ile Gly Asp Ser Val 
                165                 170                 175     


Val Ile Gly Asp Lys Val Val Leu Asn Pro Val Asn Ala Gly Gln Pro 
            180                 185                 190         


Leu His Ala Ser Ser His Gln Leu Val Asp Asn Pro Gly Cys Asn Glu 
        195                 200                 205             


Val Asn Ser Val Asn Cys Asn Thr Ser Trp Lys Ile Val Leu Phe Met 
    210                 215                 220                 


Lys Trp Ser Asp Asn Lys Asp Asp Ile Leu Lys Gly Gly Asp Val Val 
225                 230                 235                 240 


Arg Leu Phe His Ala Glu Gln Glu Lys Phe Leu Thr Cys Asp Glu His 
                245                 250                 255     


Arg Lys Lys Gln His Val Phe Leu Arg Thr Thr Gly Arg Gln Ser Ala 
            260                 265                 270         


Thr Ser Ala Thr Ser Ser Lys Ala Leu Trp Glu Val Glu Val Val Gln 
        275                 280                 285             


His Asp Pro Cys Arg Gly Gly Ala Gly Tyr Trp Asn Ser Leu Phe Arg 
    290                 295                 300                 


Phe Lys His Leu Ala Thr Gly His Tyr Leu Ala Ala Glu Val Asp Pro 
305                 310                 315                 320 


Asp Gln Asp Ala Ser Arg Ser Arg Leu Arg Asn Ala Gln Glu Lys Met 
                325                 330                 335     


Val Tyr Ser Leu Val Ser Val Pro Glu Gly Asn Asp Ile Ser Ser Ile 
            340                 345                 350         


Phe Glu Leu Asp Pro Thr Thr Leu Arg Gly Gly Asp Ser Leu Val Pro 
        355                 360                 365             


Arg Asn Ser Tyr Val Arg Leu Arg His Leu Cys Thr Asn Thr Trp Val 
    370                 375                 380                 


His Ser Thr Asn Ile Pro Ile Asp Lys Glu Glu Glu Lys Pro Val Met 
385                 390                 395                 400 


Leu Lys Ile Gly Thr Ser Pro Val Lys Glu Asp Lys Glu Ala Phe Ala 
                405                 410                 415     


Ile Val Pro Val Ser Pro Ala Glu Val Arg Asp Leu Asp Phe Ala Asn 
            420                 425                 430         


Asp Ala Ser Lys Val Leu Gly Ser Ile Ala Gly Lys Leu Glu Lys Gly 
        435                 440                 445             


Thr Ile Thr Gln Asn Glu Arg Arg Ser Val Thr Lys Leu Leu Glu Asp 
    450                 455                 460                 


Leu Val Tyr Phe Val Thr Gly Gly Thr Asn Ser Gly Gln Asp Val Leu 
465                 470                 475                 480 


Glu Val Val Phe Ser Lys Pro Asn Arg Glu Arg Gln Lys Leu Met Arg 
                485                 490                 495     


Glu Gln Asn Ile Leu Lys Gln Ile Phe Lys Leu Leu Gln Ala Pro Phe 
            500                 505                 510         


Thr Asp Cys Gly Asp Gly Pro Met Leu Arg Leu Glu Glu Leu Gly Asp 
        515                 520                 525             


Gln Arg His Ala Pro Phe Arg His Ile Cys Arg Leu Cys Tyr Arg Val 
    530                 535                 540                 


Leu Arg His Ser Gln Gln Asp Tyr Arg Lys Asn Gln Glu Tyr Ile Ala 
545                 550                 555                 560 


Lys Gln Phe Gly Phe Met Gln Lys Gln Ile Gly Tyr Asp Val Leu Ala 
                565                 570                 575     


Glu Asp Thr Ile Thr Ala Leu Leu His Asn Asn Arg Lys Leu Leu Glu 
            580                 585                 590         


Lys His Ile Thr Ala Ala Glu Ile Asp Thr Phe Val Ser Leu Val Arg 
        595                 600                 605             


Lys Asn Arg Glu Pro Arg Phe Leu Asp Tyr Leu Ser Asp Leu Cys Val 
    610                 615                 620                 


Ser Met Asn Lys Ser Ile Pro Val Thr Gln Glu Leu Ile Cys Lys Ala 
625                 630                 635                 640 


Val Leu Asn Pro Thr Asn Ala Asp Ile Leu Ile Glu Thr Lys Leu Val 
                645                 650                 655     


Leu Ser Arg Phe Glu Phe Glu Gly Val Ser Ser Thr Gly Glu Asn Ala 
            660                 665                 670         


Leu Glu Ala Gly Glu Asp Glu Glu Glu Val Trp Leu Phe Trp Arg Asp 
        675                 680                 685             


Ser Asn Lys Glu Ile Arg Ser Lys Ser Val Arg Glu Leu Ala Gln Asp 
    690                 695                 700                 


Ala Lys Glu Gly Gln Lys Glu Asp Arg Asp Val Leu Ser Tyr Tyr Arg 
705                 710                 715                 720 


Tyr Gln Leu Asn Leu Phe Ala Arg Met Cys Leu Asp Arg Gln Tyr Leu 
                725                 730                 735     


Ala Ile Asn Glu Ile Ser Gly Gln Leu Asp Val Asp Leu Ile Leu Arg 
            740                 745                 750         


Cys Met Ser Asp Glu Asn Leu Pro Tyr Asp Leu Arg Ala Ser Phe Cys 
        755                 760                 765             


Arg Leu Met Leu His Met His Val Asp Arg Asp Pro Gln Glu Gln Val 
    770                 775                 780                 


Thr Pro Val Lys Tyr Ala Arg Leu Trp Ser Glu Ile Pro Ser Glu Ile 
785                 790                 795                 800 


Ala Ile Asp Asp Tyr Asp Ser Ser Gly Ala Ser Lys Asp Glu Ile Lys 
                805                 810                 815     


Glu Arg Phe Ala Gln Thr Met Glu Phe Val Glu Glu Tyr Leu Arg Asp 
            820                 825                 830         


Val Val Cys Gln Arg Phe Pro Phe Ser Asp Lys Glu Lys Asn Lys Leu 
        835                 840                 845             


Thr Phe Glu Val Val Asn Leu Ala Arg Asn Leu Ile Tyr Phe Gly Phe 
    850                 855                 860                 


Tyr Asn Phe Ser Asp Leu Leu Arg Leu Thr Lys Ile Leu Leu Ala Ile 
865                 870                 875                 880 


Leu Asp Cys Val His Val Thr Thr Ile Phe Pro Ile Ser Lys Met Ala 
                885                 890                 895     


Lys Gly Glu Glu Asn Lys Gly Asn Asn Asp Val Glu Lys Leu Lys Ser 
            900                 905                 910         


Ser Asn Val Met Arg Ser Ile His Gly Val Gly Glu Leu Met Thr Gln 
        915                 920                 925             


Val Val Leu Arg Gly Gly Gly Phe Leu Pro Met Thr Pro Met Ala Ala 
    930                 935                 940                 


Ala Pro Glu Gly Asn Val Lys Gln Ala Glu Pro Glu Lys Glu Asp Ile 
945                 950                 955                 960 


Met Val Met Asp Thr Lys Leu Lys Ile Ile Glu Ile Leu Gln Phe Ile 
                965                 970                 975     


Leu Asn Val Arg Leu Asp Tyr Arg Ile Ser Cys Leu Leu Cys Ile Phe 
            980                 985                 990         


Lys Arg Glu Phe Asp Glu Ser Asn  Ser Gln Thr Ser Glu  Thr Ser Ser 
        995                 1000                 1005             


Gly Asn  Ser Ser Gln Glu Gly  Pro Ser Asn Val Pro  Gly Ala Leu 
    1010                 1015                 1020             


Asp Phe  Glu His Ile Glu Glu  Gln Ala Glu Gly Ile  Phe Gly Gly 
    1025                 1030                 1035             


Ser Glu  Glu Asn Thr Pro Leu  Asp Leu Asp Asp His  Gly Gly Arg 
    1040                 1045                 1050             


Thr Phe  Leu Arg Val Leu Leu  His Leu Thr Met His  Asp Tyr Pro 
    1055                 1060                 1065             


Pro Leu  Val Ser Gly Ala Leu  Gln Leu Leu Phe Arg  His Phe Ser 
    1070                 1075                 1080             


Gln Arg  Gln Glu Val Leu Gln  Ala Phe Lys Gln Val  Gln Leu Leu 
    1085                 1090                 1095             


Val Thr  Ser Gln Asp Val Asp  Asn Tyr Lys Gln Ile  Lys Gln Asp 
    1100                 1105                 1110             


Leu Asp  Gln Leu Arg Ser Ile  Val Glu Lys Ser Glu  Leu Trp Val 
    1115                 1120                 1125             


Tyr Lys  Gly Gln Gly Pro Asp  Glu Thr Met Asp Gly  Ala Ser Gly 
    1130                 1135                 1140             


Glu Asn  Glu His Lys Lys Thr  Glu Glu Gly Asn Asn  Lys Pro Gln 
    1145                 1150                 1155             


Lys His  Glu Ser Thr Ser Ser  Tyr Asn Tyr Arg Val  Val Lys Glu 
    1160                 1165                 1170             


Ile Leu  Ile Arg Leu Ser Lys  Leu Cys Val Gln Glu  Ser Ala Ser 
    1175                 1180                 1185             


Val Arg  Lys Ser Arg Lys Gln  Gln Gln Arg Leu Leu  Arg Asn Met 
    1190                 1195                 1200             


Gly Ala  His Ala Val Val Leu  Glu Leu Leu Gln Ile  Pro Tyr Glu 
    1205                 1210                 1215             


Lys Ala  Glu Asp Thr Lys Met  Gln Glu Ile Met Arg  Leu Ala His 
    1220                 1225                 1230             


Glu Phe  Leu Gln Asn Phe Cys  Ala Gly Asn Gln Gln  Asn Gln Ala 
    1235                 1240                 1245             


Leu Leu  His Lys His Ile Asn  Leu Phe Leu Asn Pro  Gly Ile Leu 
    1250                 1255                 1260             


Glu Ala  Val Thr Met Gln His  Ile Phe Met Asn Asn  Phe Gln Leu 
    1265                 1270                 1275             


Cys Ser  Glu Ile Asn Glu Arg  Val Val Gln His Phe  Val His Cys 
    1280                 1285                 1290             


Ile Glu  Thr His Gly Arg Asn  Val Gln Tyr Ile Lys  Phe Leu Gln 
    1295                 1300                 1305             


Thr Ile  Val Lys Ala Glu Gly  Lys Phe Ile Lys Lys  Cys Gln Asp 
    1310                 1315                 1320             


Met Val  Met Ala Glu Leu Val  Asn Ser Gly Glu Asp  Val Leu Val 
    1325                 1330                 1335             


Phe Tyr  Asn Asp Arg Ala Ser  Phe Gln Thr Leu Ile  Gln Met Met 
    1340                 1345                 1350             


Arg Ser  Glu Arg Asp Arg Met  Asp Glu Asn Ser Pro  Leu Met Tyr 
    1355                 1360                 1365             


His Ile  His Leu Val Glu Leu  Leu Ala Val Cys Thr  Glu Gly Lys 
    1370                 1375                 1380             


Asn Val  Tyr Thr Glu Ile Lys  Cys Asn Ser Leu Leu  Pro Leu Asp 
    1385                 1390                 1395             


Asp Ile  Val Arg Val Val Thr  His Glu Asp Cys Ile  Pro Glu Val 
    1400                 1405                 1410             


Lys Ile  Ala Tyr Ile Asn Phe  Leu Asn His Cys Tyr  Val Asp Thr 
    1415                 1420                 1425             


Glu Val  Glu Met Lys Glu Ile  Tyr Thr Ser Asn His  Met Trp Lys 
    1430                 1435                 1440             


Leu Phe  Glu Asn Phe Leu Val  Asp Ile Cys Arg Ala  Cys Asn Asn 
    1445                 1450                 1455             


Thr Ser  Asp Arg Lys His Ala  Asp Ser Ile Leu Glu  Lys Tyr Val 
    1460                 1465                 1470             


Thr Glu  Ile Val Met Ser Ile  Val Thr Thr Phe Phe  Ser Ser Pro 
    1475                 1480                 1485             


Phe Ser  Asp Gln Ser Thr Thr  Leu Gln Thr Arg Gln  Pro Val Phe 
    1490                 1495                 1500             


Val Gln  Leu Leu Gln Gly Val  Phe Arg Val Tyr His  Cys Asn Trp 
    1505                 1510                 1515             


Leu Met  Pro Ser Gln Lys Ala  Ser Val Glu Ser Cys  Ile Arg Val 
    1520                 1525                 1530             


Leu Ser  Asp Val Ala Lys Ser  Arg Ala Ile Ala Ile  Pro Val Asp 
    1535                 1540                 1545             


Leu Asp  Ser Gln Val Asn Asn  Leu Phe Leu Lys Ser  His Ser Ile 
    1550                 1555                 1560             


Val Gln  Lys Thr Ala Met Asn  Trp Arg Leu Ser Ala  Arg Asn Ala 
    1565                 1570                 1575             


Ala Arg  Arg Asp Ser Val Leu  Ala Ala Ser Arg Asp  Tyr Arg Asn 
    1580                 1585                 1590             


Ile Ile  Glu Arg Leu Gln Asp  Ile Val Ser Ala Leu  Glu Asp Arg 
    1595                 1600                 1605             


Leu Arg  Pro Leu Val Gln Ala  Glu Leu Ser Val Leu  Val Asp Val 
    1610                 1615                 1620             


Leu His  Arg Pro Glu Leu Leu  Phe Pro Glu Asn Thr  Asp Ala Arg 
    1625                 1630                 1635             


Arg Lys  Cys Glu Ser Gly Gly  Phe Ile Cys Lys Leu  Ile Lys His 
    1640                 1645                 1650             


Thr Lys  Gln Leu Leu Glu Glu  Asn Glu Glu Lys Leu  Cys Ile Lys 
    1655                 1660                 1665             


Val Leu  Gln Thr Leu Arg Glu  Met Met Thr Lys Asp  Arg Gly Tyr 
    1670                 1675                 1680             


Gly Glu  Lys Leu Ile Ser Ile  Asp Glu Leu Asp Asn  Ala Glu Leu 
    1685                 1690                 1695             


Pro Pro  Ala Pro Asp Ser Glu  Asn Ala Thr Glu Glu  Leu Glu Pro 
    1700                 1705                 1710             


Ser Pro  Pro Leu Arg Gln Leu  Glu Asp His Lys Arg  Gly Glu Ala 
    1715                 1720                 1725             


Leu Arg  Gln Val Leu Val Asn  Arg Tyr Tyr Gly Asn  Val Arg Pro 
    1730                 1735                 1740             


Ser Gly  Arg Arg Glu Ser Leu  Thr Ser Phe Gly Asn  Gly Pro Leu 
    1745                 1750                 1755             


Ser Ala  Gly Gly Pro Gly Lys  Pro Gly Gly Gly Gly  Gly Gly Ser 
    1760                 1765                 1770             


Gly Ser  Ser Ser Met Ser Arg  Gly Glu Met Ser Leu  Ala Glu Val 
    1775                 1780                 1785             


Gln Cys  His Leu Asp Lys Glu  Gly Ala Ser Asn Leu  Val Ile Asp 
    1790                 1795                 1800             


Leu Ile  Met Asn Ala Ser Ser  Asp Arg Val Phe His  Glu Ser Ile 
    1805                 1810                 1815             


Leu Leu  Ala Ile Ala Leu Leu  Glu Gly Gly Asn Thr  Thr Ile Gln 
    1820                 1825                 1830             


His Ser  Phe Phe Cys Arg Leu  Thr Glu Asp Lys Lys  Ser Glu Lys 
    1835                 1840                 1845             


Phe Phe  Lys Val Phe Tyr Asp  Arg Met Lys Val Ala  Gln Gln Glu 
    1850                 1855                 1860             


Ile Lys  Ala Thr Val Thr Val  Asn Thr Ser Asp Leu  Gly Asn Lys 
    1865                 1870                 1875             


Lys Lys  Asp Asp Glu Val Asp  Arg Asp Ala Pro Ser  Arg Lys Lys 
    1880                 1885                 1890             


Ala Lys  Glu Pro Thr Thr Gln  Ile Thr Glu Glu Val  Arg Asp Gln 
    1895                 1900                 1905             


Leu Leu  Glu Ala Ser Ala Ala  Thr Arg Lys Ala Phe  Thr Thr Phe 
    1910                 1915                 1920             


Arg Arg  Glu Ala Asp Pro Asp  Asp His Tyr Gln Pro  Gly Glu Gly 
    1925                 1930                 1935             


Thr Gln  Ala Thr Ala Asp Lys  Ala Lys Asp Asp Leu  Glu Met Ser 
    1940                 1945                 1950             


Ala Val  Ile Thr Ile Met Gln  Pro Ile Leu Arg Phe  Leu Gln Leu 
    1955                 1960                 1965             


Leu Cys  Glu Asn His Asn Arg  Asp Leu Gln Asn Phe  Leu Arg Cys 
    1970                 1975                 1980             


Gln Asn  Asn Lys Thr Asn Tyr  Asn Leu Val Cys Glu  Thr Leu Gln 
    1985                 1990                 1995             


Phe Leu  Asp Cys Ile Cys Gly  Ser Thr Thr Gly Gly  Leu Gly Leu 
    2000                 2005                 2010             


Leu Gly  Leu Tyr Ile Asn Glu  Lys Asn Val Ala Leu  Ile Asn Gln 
    2015                 2020                 2025             


Thr Leu  Glu Ser Leu Thr Glu  Tyr Cys Gln Gly Pro  Cys His Glu 
    2030                 2035                 2040             


Asn Gln  Asn Cys Ile Ala Thr  His Glu Ser Asn Gly  Ile Asp Ile 
    2045                 2050                 2055             


Ile Thr  Ala Leu Ile Leu Asn  Asp Ile Asn Pro Leu  Gly Lys Lys 
    2060                 2065                 2070             


Arg Met  Asp Leu Val Leu Glu  Leu Lys Asn Asn Ala  Ser Lys Leu 
    2075                 2080                 2085             


Leu Leu  Ala Ile Met Glu Ser  Arg His Asp Ser Glu  Asn Ala Glu 
    2090                 2095                 2100             


Arg Ile  Leu Tyr Asn Met Arg  Pro Lys Glu Leu Val  Glu Val Ile 
    2105                 2110                 2115             


Lys Lys  Ala Tyr Met Gln Gly  Glu Val Glu Phe Glu  Asp Gly Glu 
    2120                 2125                 2130             


Asn Gly  Glu Asp Gly Ala Ala  Ser Pro Arg Asn Val  Gly His Asn 
    2135                 2140                 2145             


Ile Tyr  Ile Leu Ala His Gln  Leu Ala Arg His Asn  Lys Glu Leu 
    2150                 2155                 2160             


Gln Ser  Met Leu Lys Pro Gly  Gly Gln Val Asp Gly  Asp Glu Ala 
    2165                 2170                 2175             


Leu Glu  Phe Tyr Ala Lys His  Thr Ala Gln Ile Glu  Ile Val Arg 
    2180                 2185                 2190             


Leu Asp  Arg Thr Met Glu Gln  Ile Val Phe Pro Val  Pro Ser Ile 
    2195                 2200                 2205             


Cys Glu  Phe Leu Thr Lys Glu  Ser Lys Leu Arg Ile  Tyr Tyr Thr 
    2210                 2215                 2220             


Thr Glu  Arg Asp Glu Gln Gly  Ser Lys Ile Asn Asp  Phe Phe Leu 
    2225                 2230                 2235             


Arg Ser  Glu Asp Leu Phe Asn  Glu Met Asn Trp Gln  Lys Lys Leu 
    2240                 2245                 2250             


Arg Ala  Gln Pro Val Leu Tyr  Trp Cys Ala Arg Asn  Met Ser Phe 
    2255                 2260                 2265             


Trp Ser  Ser Ile Ser Phe Asn  Leu Ala Val Leu Met  Asn Leu Leu 
    2270                 2275                 2280             


Val Ala  Phe Phe Tyr Pro Phe  Lys Gly Val Arg Gly  Gly Thr Leu 
    2285                 2290                 2295             


Glu Pro  His Trp Ser Gly Leu  Leu Trp Thr Ala Met  Leu Ile Ser 
    2300                 2305                 2310             


Leu Ala  Ile Val Ile Ala Leu  Pro Lys Pro His Gly  Ile Arg Ala 
    2315                 2320                 2325             


Leu Ile  Ala Ser Thr Ile Leu  Arg Leu Ile Phe Ser  Val Gly Leu 
    2330                 2335                 2340             


Gln Pro  Thr Leu Phe Leu Leu  Gly Ala Phe Asn Val  Cys Asn Lys 
    2345                 2350                 2355             


Ile Ile  Phe Leu Met Ser Phe  Val Gly Asn Cys Gly  Thr Phe Thr 
    2360                 2365                 2370             


Arg Gly  Tyr Arg Ala Met Val  Leu Asp Val Glu Phe  Leu Tyr His 
    2375                 2380                 2385             


Leu Leu  Tyr Leu Val Ile Cys  Ala Met Gly Leu Phe  Val His Glu 
    2390                 2395                 2400             


Phe Phe  Tyr Ser Leu Leu Leu  Phe Asp Leu Val Tyr  Arg Glu Glu 
    2405                 2410                 2415             


Thr Leu  Leu Asn Val Ile Lys  Ser Val Thr Arg Asn  Gly Arg Ser 
    2420                 2425                 2430             


Ile Ile  Leu Thr Ala Val Leu  Ala Leu Ile Leu Val  Tyr Leu Phe 
    2435                 2440                 2445             


Ser Ile  Val Gly Tyr Leu Phe  Phe Lys Asp Asp Phe  Ile Leu Glu 
    2450                 2455                 2460             


Val Asp  Arg Leu Pro Asn Glu  Thr Ala Val Pro Glu  Thr Gly Glu 
    2465                 2470                 2475             


Ser Leu  Ala Ser Glu Phe Leu  Phe Ser Asp Val Cys  Arg Val Glu 
    2480                 2485                 2490             


Ser Gly  Glu Asn Cys Ser Ser  Pro Ala Pro Arg Glu  Glu Leu Val 
    2495                 2500                 2505             


Pro Ala  Glu Glu Thr Glu Gln  Asp Lys Glu His Thr  Cys Glu Thr 
    2510                 2515                 2520             


Leu Leu  Met Cys Ile Val Thr  Val Leu Ser His Gly  Leu Arg Ser 
    2525                 2530                 2535             


Gly Gly  Gly Val Gly Asp Val  Leu Arg Lys Pro Ser  Lys Glu Glu 
    2540                 2545                 2550             


Pro Leu  Phe Ala Ala Arg Val  Ile Tyr Asp Leu Leu  Phe Phe Phe 
    2555                 2560                 2565             


Met Val  Ile Ile Ile Val Leu  Asn Leu Ile Phe Gly  Val Ile Ile 
    2570                 2575                 2580             


Asp Thr  Phe Ala Asp Leu Arg  Ser Glu Lys Gln Lys  Lys Glu Glu 
    2585                 2590                 2595             


Ile Leu  Lys Thr Thr Cys Phe  Ile Cys Gly Leu Glu  Arg Asp Lys 
    2600                 2605                 2610             


Phe Asp  Asn Lys Thr Val Thr  Phe Glu Glu His Ile  Lys Glu Glu 
    2615                 2620                 2625             


His Asn  Met Trp His Tyr Leu  Cys Phe Ile Val Leu  Val Lys Val 
    2630                 2635                 2640             


Lys Asp  Ser Thr Glu Tyr Thr  Gly Pro Glu Ser Tyr  Val Ala Glu 
    2645                 2650                 2655             


Met Ile  Lys Glu Arg Asn Leu  Asp Trp Phe Pro Arg  Met Arg Ala 
    2660                 2665                 2670             


Met Ser  Leu Val Ser Ser Asp  Ser Glu Gly Glu Gln  Asn Glu Leu 
    2675                 2680                 2685             


Arg Asn  Leu Gln Glu Lys Leu  Glu Ser Thr Met Lys  Leu Val Thr 
    2690                 2695                 2700             


Asn Leu  Ser Gly Gln Leu Ser  Glu Leu Lys Asp Gln  Met Thr Glu 
    2705                 2710                 2715             


Gln Arg  Lys Gln Lys Gln Arg  Ile Gly Leu Leu Gly  His Pro Pro 
    2720                 2725                 2730             


His Met  Asn Val Asn Pro Gln  Gln Pro Ala 
    2735                 2740             


<210>  2215
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  2215

Met Glu Asp Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys 
1               5                   10                  15      


Gly Glu Asp Leu Ser Asn Tyr Ser Tyr Ser Ser Thr Leu Pro Pro Phe 
            20                  25                  30          


Leu Leu Asp Ala Ala Pro Cys Glu Pro Glu Ser Leu Glu Ile Asn Lys 
        35                  40                  45              


Tyr Phe Val Val Ile Ile Tyr Ala Leu Val Phe Leu Leu Ser Leu Leu 
    50                  55                  60                  


Gly Asn Ser Leu Val Met Leu Val Ile Leu Tyr Ser Arg Val Gly Arg 
65                  70                  75                  80  


Ser Val Thr Asp Val Tyr Leu Leu Asn Leu Ala Leu Ala Asp Leu Leu 
                85                  90                  95      


Phe Ala Leu Thr Leu Pro Ile Trp Ala Ala Ser Lys Val Asn Gly Trp 
            100                 105                 110         


Ile Phe Gly Thr Phe Leu Cys Lys Val Val Ser Leu Leu Lys Glu Val 
        115                 120                 125             


Asn Phe Tyr Ser Gly Ile Leu Leu Leu Ala Cys Ile Ser Val Asp Arg 
    130                 135                 140                 


Tyr Leu Ala Ile Val His Ala Thr Arg Thr Leu Thr Gln Lys Arg Tyr 
145                 150                 155                 160 


Leu Val Lys Phe Ile Cys Leu Ser Ile Trp Gly Leu Ser Leu Leu Leu 
                165                 170                 175     


Ala Leu Pro Val Leu Leu Phe Arg Arg Thr Val Tyr Ser Ser Asn Val 
            180                 185                 190         


Ser Pro Ala Cys Tyr Glu Asp Met Gly Asn Asn Thr Ala Asn Trp Arg 
        195                 200                 205             


Met Leu Leu Arg Ile Leu Pro Gln Ser Phe Gly Phe Ile Val Pro Leu 
    210                 215                 220                 


Leu Ile Met Leu Phe Cys Tyr Gly Phe Thr Leu Arg Thr Leu Phe Lys 
225                 230                 235                 240 


Ala His Met Gly Gln Lys His Arg Ala Met Arg Val Ile Phe Ala Val 
                245                 250                 255     


Val Leu Ile Phe Leu Leu Cys Trp Leu Pro Tyr Asn Leu Val Leu Leu 
            260                 265                 270         


Ala Asp Thr Leu Met Arg Thr Gln Val Ile Gln Glu Thr Cys Glu Arg 
        275                 280                 285             


Arg Asn His Ile Asp Arg Ala Leu Asp Ala Thr Glu Ile Leu Gly Ile 
    290                 295                 300                 


Leu His Ser Cys Leu Asn Pro Leu Ile Tyr Ala Phe Ile Gly Gln Lys 
305                 310                 315                 320 


Phe Arg His Gly Leu Leu Lys Ile Leu Ala Ile His Gly Leu Ile Ser 
                325                 330                 335     


Lys Asp Ser Leu Pro Lys Asp Ser Arg Pro Ser Phe Val Gly Ser Ser 
            340                 345                 350         


Ser Gly His Thr Ser Thr Thr Leu 
        355                 360 


<210>  2216
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  2216

Met Ala Arg Gly Cys Leu Cys Cys Leu Lys Tyr Met Met Phe Leu Phe 
1               5                   10                  15      


Asn Leu Ile Phe Trp Leu Cys Gly Cys Gly Leu Leu Gly Val Gly Ile 
            20                  25                  30          


Trp Leu Ser Val Ser Gln Gly Asn Phe Ala Thr Phe Ser Pro Ser Phe 
        35                  40                  45              


Pro Ser Leu Ser Ala Ala Asn Leu Val Ile Ala Ile Gly Thr Ile Val 
    50                  55                  60                  


Met Val Thr Gly Phe Leu Gly Cys Leu Gly Ala Ile Lys Glu Asn Lys 
65                  70                  75                  80  


Cys Leu Leu Leu Ser Phe Phe Ile Val Leu Leu Val Ile Leu Leu Ala 
                85                  90                  95      


Glu Leu Ile Leu Leu Ile Leu Phe Phe Val Tyr Met Asp Lys Val Asn 
            100                 105                 110         


Glu Asn Ala Lys Lys Asp Leu Lys Glu Gly Leu Leu Leu Tyr His Thr 
        115                 120                 125             


Glu Asn Asn Val Gly Leu Lys Asn Ala Trp Asn Ile Ile Gln Ala Glu 
    130                 135                 140                 


Met Arg Cys Cys Gly Val Thr Asp Tyr Thr Asp Trp Tyr Pro Val Leu 
145                 150                 155                 160 


Gly Glu Asn Thr Val Pro Asp Arg Cys Cys Met Glu Asn Ser Gln Gly 
                165                 170                 175     


Cys Gly Arg Asn Ala Thr Thr Pro Leu Trp Arg Thr Gly Cys Tyr Glu 
            180                 185                 190         


Lys Val Lys Met Trp Phe Asp Asp Asn Lys His Val Leu Gly Thr Val 
        195                 200                 205             


Gly Met Cys Ile Leu Ile Met Gln Ile Leu Gly Met Ala Phe Ser Met 
    210                 215                 220                 


Thr Leu Phe Gln His Ile His Arg Thr Gly Lys Lys Tyr Asp Ala 
225                 230                 235                 


<210>  2217
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  2217

Met Arg Leu Leu Val Leu Leu Trp Gly Cys Leu Leu Leu Pro Gly Tyr 
1               5                   10                  15      


Glu Ala Leu Glu Gly Pro Glu Glu Ile Ser Gly Phe Glu Gly Asp Thr 
            20                  25                  30          


Val Ser Leu Gln Cys Thr Tyr Arg Glu Glu Leu Arg Asp His Arg Lys 
        35                  40                  45              


Tyr Trp Cys Arg Lys Gly Gly Ile Leu Phe Ser Arg Cys Ser Gly Thr 
    50                  55                  60                  


Ile Tyr Ala Glu Glu Glu Gly Gln Glu Thr Met Lys Gly Arg Val Ser 
65                  70                  75                  80  


Ile Arg Asp Ser Arg Gln Glu Leu Ser Leu Ile Val Thr Leu Trp Asn 
                85                  90                  95      


Leu Thr Leu Gln Asp Ala Gly Glu Tyr Trp Cys Gly Val Glu Lys Arg 
            100                 105                 110         


Gly Pro Asp Glu Ser Leu Leu Ile Ser Leu Phe Val Phe Pro Gly Pro 
        115                 120                 125             


Cys Cys Pro Pro Ser Pro Ser Pro Thr Phe Gln Pro Leu Ala Thr Thr 
    130                 135                 140                 


Arg Leu Gln Pro Lys Ala Lys Ala Gln Gln Thr Gln Pro Pro Gly Leu 
145                 150                 155                 160 


Thr Ser Pro Gly Leu Tyr Pro Ala Ala Thr Thr Ala Lys Gln Gly Lys 
                165                 170                 175     


Thr Gly Ala Glu Ala Pro Pro Leu Pro Gly Thr Ser Gln Tyr Gly His 
            180                 185                 190         


Glu Arg Thr Ser Gln Tyr Thr Gly Thr Ser Pro His Pro Ala Thr Ser 
        195                 200                 205             


Pro Pro Ala Gly Ser Ser Arg Pro Pro Met Gln Leu Asp Ser Thr Ser 
    210                 215                 220                 


Ala Glu Asp Thr Ser Pro Ala Leu Ser Ser Gly Ser Ser Lys Pro Arg 
225                 230                 235                 240 


Val Ser Ile Pro Met Val Arg Ile Leu Ala Pro Val Leu Val Leu Leu 
                245                 250                 255     


Ser Leu Leu Ser Ala Ala Gly Leu Ile Ala Phe Cys Ser His Leu Leu 
            260                 265                 270         


Leu Trp Arg Lys Glu Ala Gln Gln Ala Thr Glu Thr Gln Arg Asn Glu 
        275                 280                 285             


Lys Phe Cys Leu Ser Arg Leu Asn Ser Leu Met Phe Ser Leu Ser Leu 
    290                 295                 300                 


Pro Trp Leu 
305         


<210>  2218
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  2218

Met Arg Leu Leu Val Leu Leu Trp Gly Cys Leu Leu Leu Pro Gly Tyr 
1               5                   10                  15      


Glu Ala Leu Glu Gly Pro Glu Glu Ile Ser Gly Phe Glu Gly Asp Thr 
            20                  25                  30          


Val Ser Leu Gln Cys Thr Tyr Arg Glu Glu Leu Arg Asp His Arg Lys 
        35                  40                  45              


Tyr Trp Cys Arg Lys Gly Gly Ile Leu Phe Ser Arg Cys Ser Gly Thr 
    50                  55                  60                  


Ile Tyr Ala Glu Glu Glu Gly Gln Glu Thr Met Lys Gly Arg Val Ser 
65                  70                  75                  80  


Ile Arg Asp Ser Arg Gln Glu Leu Ser Leu Ile Val Thr Leu Trp Asn 
                85                  90                  95      


Leu Thr Leu Gln Asp Ala Gly Glu Tyr Trp Cys Gly Val Glu Lys Arg 
            100                 105                 110         


Gly Pro Asp Glu Ser Leu Leu Ile Ser Leu Phe Val Phe Pro Ala Ser 
        115                 120                 125             


Pro Gly Leu Tyr Pro Ala Ala Thr Thr Ala Lys Gln Gly Lys Thr Gly 
    130                 135                 140                 


Ala Glu Ala Pro Pro Leu Pro Gly Thr Ser Gln Tyr Gly His Glu Arg 
145                 150                 155                 160 


Thr Ser Gln Tyr Thr Gly Thr Ser Pro His Pro Ala Thr Ser Pro Pro 
                165                 170                 175     


Ala Gly Ser Ser Arg Pro Pro Met Gln Leu Asp Ser Thr Ser Ala Glu 
            180                 185                 190         


Asp Thr Ser Pro Ala Leu Ser Ser Gly Ser Ser Lys Pro Arg Val Ser 
        195                 200                 205             


Ile Pro Met Val Arg Ile Leu Ala Pro Val Leu Val Leu Leu Ser Leu 
    210                 215                 220                 


Leu Ser Ala Ala Gly Leu Ile Ala Phe Cys Ser His Leu Leu Leu Trp 
225                 230                 235                 240 


Arg Lys Glu Ala Gln Gln Ala Thr Glu Thr Gln Arg Asn Glu Lys Phe 
                245                 250                 255     


Cys Leu Ser Arg Leu Asn Ser Leu Met Phe Ser Leu Ser Leu Pro Trp 
            260                 265                 270         


Leu 
    


<210>  2219
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  2219

Met Arg Leu Leu Val Leu Leu Trp Gly Cys Leu Leu Leu Pro Gly Tyr 
1               5                   10                  15      


Glu Ala Leu Glu Gly Pro Glu Glu Ile Ser Gly Phe Glu Gly Asp Thr 
            20                  25                  30          


Val Ser Leu Gln Cys Thr Tyr Arg Glu Glu Leu Arg Asp His Arg Lys 
        35                  40                  45              


Tyr Trp Cys Arg Lys Gly Gly Ile Leu Phe Ser Arg Cys Ser Gly Thr 
    50                  55                  60                  


Ile Tyr Ala Glu Glu Glu Gly Gln Glu Thr Met Lys Gly Arg Val Ser 
65                  70                  75                  80  


Ile Arg Asp Ser Arg Gln Glu Leu Ser Leu Ile Val Thr Leu Trp Asn 
                85                  90                  95      


Leu Thr Leu Gln Asp Ala Gly Glu Tyr Trp Cys Gly Val Glu Lys Arg 
            100                 105                 110         


Gly Pro Asp Glu Ser Leu Leu Ile Ser Leu Phe Val Phe Pro Gly Ser 
        115                 120                 125             


Ser Arg Pro Pro Met Gln Leu Asp Ser Thr Ser Ala Glu Asp Thr Ser 
    130                 135                 140                 


Pro Ala Leu Ser Ser Gly Ser Ser Lys Pro Arg Val Ser Ile Pro Met 
145                 150                 155                 160 


Val Arg Ile Leu Ala Pro Val Leu Val Leu Leu Ser Leu Leu Ser Ala 
                165                 170                 175     


Ala Gly Leu Ile Ala Phe Cys Ser His Leu Leu Leu Trp Arg Lys Glu 
            180                 185                 190         


Ala Gln Gln Ala Thr Glu Thr Gln Arg Asn Glu Lys Phe Cys Leu Ser 
        195                 200                 205             


Arg Leu Asn His Arg Thr Ser Glu Leu Asp Pro Asp Glu Ala Phe Glu 
    210                 215                 220                 


Ile Ser Ser Leu Thr Phe Leu Ser Val 
225                 230             


<210>  2220
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  2220

Met Ala Leu Phe Ala Val Phe Gln Thr Thr Phe Phe Leu Thr Leu Leu 
1               5                   10                  15      


Ser Leu Arg Thr Tyr Gln Ser Glu Val Leu Ala Glu Arg Leu Pro Leu 
            20                  25                  30          


Thr Pro Val Ser Leu Lys Val Ser Thr Asn Ser Thr Arg Gln Ser Leu 
        35                  40                  45              


His Leu Gln Trp Thr Val His Asn Leu Pro Tyr His Gln Glu Leu Lys 
    50                  55                  60                  


Met Val Phe Gln Ile Gln Ile Ser Arg Ile Glu Thr Ser Asn Val Ile 
65                  70                  75                  80  


Trp Val Gly Asn Tyr Ser Thr Thr Val Lys Trp Asn Gln Val Leu His 
                85                  90                  95      


Trp Ser Trp Glu Ser Glu Leu Pro Leu Glu Cys Ala Thr His Phe Val 
            100                 105                 110         


Arg Ile Lys Ser Leu Val Asp Asp Ala Lys Phe Pro Glu Pro Asn Phe 
        115                 120                 125             


Trp Ser Asn Trp Ser Ser Trp Glu Glu Val Ser Val Gln Asp Ser Thr 
    130                 135                 140                 


Gly Gln Asp Ile Leu Phe Val Phe Pro Lys Asp Lys Leu Val Glu Glu 
145                 150                 155                 160 


Gly Thr Asn Val Thr Ile Cys Tyr Val Ser Arg Asn Ile Gln Asn Asn 
                165                 170                 175     


Val Ser Cys Tyr Leu Glu Gly Lys Gln Ile His Gly Glu Gln Leu Asp 
            180                 185                 190         


Pro His Val Thr Ala Phe Asn Leu Asn Ser Val Pro Phe Ile Arg Asn 
        195                 200                 205             


Lys Gly Thr Asn Ile Tyr Cys Glu Ala Ser Gln Gly Asn Val Ser Glu 
    210                 215                 220                 


Gly Met Lys Gly Ile Val Leu Phe Val Ser Lys Val Leu Glu Glu Pro 
225                 230                 235                 240 


Lys Asp Phe Ser Cys Glu Thr Glu Asp Phe Lys Thr Leu His Cys Thr 
                245                 250                 255     


Trp Asp Pro Gly Thr Asp Thr Ala Leu Gly Trp Ser Lys Gln Pro Ser 
            260                 265                 270         


Gln Ser Tyr Thr Leu Phe Glu Ser Phe Ser Gly Glu Lys Lys Leu Cys 
        275                 280                 285             


Thr His Lys Asn Trp Cys Asn Trp Gln Ile Thr Gln Asp Ser Gln Glu 
    290                 295                 300                 


Thr Tyr Asn Phe Thr Leu Ile Ala Glu Asn Tyr Leu Arg Lys Arg Ser 
305                 310                 315                 320 


Val Asn Ile Leu Phe Asn Leu Thr His Arg Gly Glu Thr Arg Val Val 
                325                 330                 335     


Thr Ala His Arg Gly His 
            340         


<210>  2221
<211>  1339
<212>  PRT
<213>  Homo sapiens

<400>  2221

Met Asp Leu Leu Ser Gly Thr Tyr Ile Phe Ala Val Leu Leu Ala Cys 
1               5                   10                  15      


Val Val Phe His Ser Gly Ala Gln Glu Lys Asn Tyr Thr Ile Arg Glu 
            20                  25                  30          


Glu Met Pro Glu Asn Val Leu Ile Gly Asp Leu Leu Lys Asp Leu Asn 
        35                  40                  45              


Leu Ser Leu Ile Pro Asn Lys Ser Leu Thr Thr Ala Met Gln Phe Lys 
    50                  55                  60                  


Leu Val Tyr Lys Thr Gly Asp Val Pro Leu Ile Arg Ile Glu Glu Asp 
65                  70                  75                  80  


Thr Gly Glu Ile Phe Thr Thr Gly Ala Arg Ile Asp Arg Glu Lys Leu 
                85                  90                  95      


Cys Ala Gly Ile Pro Arg Asp Glu His Cys Phe Tyr Glu Val Glu Val 
            100                 105                 110         


Ala Ile Leu Pro Asp Glu Ile Phe Arg Leu Val Lys Ile Arg Phe Leu 
        115                 120                 125             


Ile Glu Asp Ile Asn Asp Asn Ala Pro Leu Phe Pro Ala Thr Val Ile 
    130                 135                 140                 


Asn Ile Ser Ile Pro Glu Asn Ser Ala Ile Asn Ser Lys Tyr Thr Leu 
145                 150                 155                 160 


Pro Ala Ala Val Asp Pro Asp Val Gly Ile Asn Gly Val Gln Asn Tyr 
                165                 170                 175     


Glu Leu Ile Lys Ser Gln Asn Ile Phe Gly Leu Asp Val Ile Glu Thr 
            180                 185                 190         


Pro Glu Gly Asp Lys Met Pro Gln Leu Ile Val Gln Lys Glu Leu Asp 
        195                 200                 205             


Arg Glu Glu Lys Asp Thr Tyr Val Met Lys Val Lys Val Glu Asp Gly 
    210                 215                 220                 


Gly Phe Pro Gln Arg Ser Ser Thr Ala Ile Leu Gln Val Ser Val Thr 
225                 230                 235                 240 


Asp Thr Asn Asp Asn His Pro Val Phe Lys Glu Thr Glu Ile Glu Val 
                245                 250                 255     


Ser Ile Pro Glu Asn Ala Pro Val Gly Thr Ser Val Thr Gln Leu His 
            260                 265                 270         


Ala Thr Asp Ala Asp Ile Gly Glu Asn Ala Lys Ile His Phe Ser Phe 
        275                 280                 285             


Ser Asn Leu Val Ser Asn Ile Ala Arg Arg Leu Phe His Leu Asn Ala 
    290                 295                 300                 


Thr Thr Gly Leu Ile Thr Ile Lys Glu Pro Leu Asp Arg Glu Glu Thr 
305                 310                 315                 320 


Pro Asn His Lys Leu Leu Val Leu Ala Ser Asp Gly Gly Leu Met Pro 
                325                 330                 335     


Ala Arg Ala Met Val Leu Val Asn Val Thr Asp Val Asn Asp Asn Val 
            340                 345                 350         


Pro Ser Ile Asp Ile Arg Tyr Ile Val Asn Pro Val Asn Asp Thr Val 
        355                 360                 365             


Val Leu Ser Glu Asn Ile Pro Leu Asn Thr Lys Ile Ala Leu Ile Thr 
    370                 375                 380                 


Val Thr Asp Lys Asp Ala Asp His Asn Gly Arg Val Thr Cys Phe Thr 
385                 390                 395                 400 


Asp His Glu Ile Pro Phe Arg Leu Arg Pro Val Phe Ser Asn Gln Phe 
                405                 410                 415     


Leu Leu Glu Thr Ala Ala Tyr Leu Asp Tyr Glu Ser Thr Lys Glu Tyr 
            420                 425                 430         


Ala Ile Lys Leu Leu Ala Ala Asp Ala Gly Lys Pro Pro Leu Asn Gln 
        435                 440                 445             


Ser Ala Met Leu Phe Ile Lys Val Lys Asp Glu Asn Asp Asn Ala Pro 
    450                 455                 460                 


Val Phe Thr Gln Ser Phe Val Thr Val Ser Ile Pro Glu Asn Asn Ser 
465                 470                 475                 480 


Pro Gly Ile Gln Leu Thr Lys Val Ser Ala Met Asp Ala Asp Ser Gly 
                485                 490                 495     


Pro Asn Ala Lys Ile Asn Tyr Leu Leu Gly Pro Asp Ala Pro Pro Glu 
            500                 505                 510         


Phe Ser Leu Asp Cys Arg Thr Gly Met Leu Thr Val Val Lys Lys Leu 
        515                 520                 525             


Asp Arg Glu Lys Glu Asp Lys Tyr Leu Phe Thr Ile Leu Ala Lys Asp 
    530                 535                 540                 


Asn Gly Val Pro Pro Leu Thr Ser Asn Val Thr Val Phe Val Ser Ile 
545                 550                 555                 560 


Ile Asp Gln Asn Asp Asn Ser Pro Val Phe Thr His Asn Glu Tyr Asn 
                565                 570                 575     


Phe Tyr Val Pro Glu Asn Leu Pro Arg His Gly Thr Val Gly Leu Ile 
            580                 585                 590         


Thr Val Thr Asp Pro Asp Tyr Gly Asp Asn Ser Ala Val Thr Leu Ser 
        595                 600                 605             


Ile Leu Asp Glu Asn Asp Asp Phe Thr Ile Asp Ser Gln Thr Gly Val 
    610                 615                 620                 


Ile Arg Pro Asn Ile Ser Phe Asp Arg Glu Lys Gln Glu Ser Tyr Thr 
625                 630                 635                 640 


Phe Tyr Val Lys Ala Glu Asp Gly Gly Arg Val Ser Arg Ser Ser Ser 
                645                 650                 655     


Ala Lys Val Thr Ile Asn Val Val Asp Val Asn Asp Asn Lys Pro Val 
            660                 665                 670         


Phe Ile Val Pro Pro Ser Asn Cys Ser Tyr Glu Leu Val Leu Pro Ser 
        675                 680                 685             


Thr Asn Pro Gly Thr Val Val Phe Gln Val Ile Ala Val Asp Asn Asp 
    690                 695                 700                 


Thr Gly Met Asn Ala Glu Val Arg Tyr Ser Ile Val Gly Gly Asn Thr 
705                 710                 715                 720 


Arg Asp Leu Phe Ala Ile Asp Gln Glu Thr Gly Asn Ile Thr Leu Met 
                725                 730                 735     


Glu Lys Cys Asp Val Thr Asp Leu Gly Leu His Arg Val Leu Val Lys 
            740                 745                 750         


Ala Asn Asp Leu Gly Gln Pro Asp Ser Leu Phe Ser Val Val Ile Val 
        755                 760                 765             


Asn Leu Phe Val Asn Glu Ser Val Thr Asn Ala Thr Leu Ile Asn Glu 
    770                 775                 780                 


Leu Val Arg Lys Ser Thr Glu Ala Pro Val Thr Pro Asn Thr Glu Ile 
785                 790                 795                 800 


Ala Asp Val Ser Ser Pro Thr Ser Asp Tyr Val Lys Ile Leu Val Ala 
                805                 810                 815     


Ala Val Ala Gly Thr Ile Thr Val Val Val Val Ile Phe Ile Thr Ala 
            820                 825                 830         


Val Val Arg Cys Arg Gln Ala Pro His Leu Lys Ala Ala Gln Lys Asn 
        835                 840                 845             


Lys Gln Asn Ser Glu Trp Ala Thr Pro Asn Pro Glu Asn Arg Gln Met 
    850                 855                 860                 


Ile Met Met Lys Lys Lys Lys Lys Lys Lys Lys His Ser Pro Lys Asn 
865                 870                 875                 880 


Leu Leu Leu Asn Phe Val Thr Ile Glu Glu Thr Lys Ala Asp Asp Val 
                885                 890                 895     


Asp Ser Asp Gly Asn Arg Val Thr Leu Asp Leu Pro Ile Asp Leu Glu 
            900                 905                 910         


Glu Gln Thr Met Gly Lys Tyr Asn Trp Val Thr Thr Pro Thr Thr Phe 
        915                 920                 925             


Lys Pro Asp Ser Pro Asp Leu Ala Arg His Tyr Lys Ser Ala Ser Pro 
    930                 935                 940                 


Gln Pro Ala Phe Gln Ile Gln Pro Glu Thr Pro Leu Asn Ser Lys His 
945                 950                 955                 960 


His Ile Ile Gln Glu Leu Pro Leu Asp Asn Thr Phe Val Ala Cys Asp 
                965                 970                 975     


Ser Ile Ser Lys Cys Ser Ser Ser Ser Ser Asp Pro Tyr Ser Val Ser 
            980                 985                 990         


Asp Cys Gly Tyr Pro Val Thr Thr  Phe Glu Val Pro Val  Ser Val His 
        995                 1000                 1005             


Thr Arg  Pro Pro Met Lys Glu  Val Val Arg Ser Cys  Thr Pro Met 
    1010                 1015                 1020             


Lys Glu  Ser Thr Thr Met Glu  Ile Trp Ile His Pro  Gln Pro Gln 
    1025                 1030                 1035             


Arg Lys  Ser Glu Gly Lys Val  Ala Gly Lys Ser Gln  Arg Arg Val 
    1040                 1045                 1050             


Thr Phe  His Leu Pro Glu Gly  Ser Gln Glu Ser Ser  Ser Asp Gly 
    1055                 1060                 1065             


Gly Leu  Gly Asp His Asp Ala  Gly Ser Leu Thr Ser  Thr Ser His 
    1070                 1075                 1080             


Gly Leu  Pro Leu Gly Tyr Pro  Gln Glu Glu Tyr Phe  Asp Arg Ala 
    1085                 1090                 1095             


Thr Pro  Ser Asn Arg Thr Glu  Gly Asp Gly Asn Ser  Asp Pro Glu 
    1100                 1105                 1110             


Ser Thr  Ala Glu Ile Thr Val  Gln Pro Thr Val Glu  Glu Ala Ser 
    1115                 1120                 1125             


Asp Asn  Cys Thr Gln Glu Cys  Leu Ile Tyr Gly His  Ser Asp Ala 
    1130                 1135                 1140             


Cys Trp  Met Pro Ala Ser Leu  Asp His Ser Ser Ser  Ser Gln Ala 
    1145                 1150                 1155             


Gln Ala  Ser Ala Leu Cys His  Ser Pro Pro Leu Ser  Gln Ala Ser 
    1160                 1165                 1170             


Thr Gln  His His Ser Pro Arg  Val Thr Gln Thr Ile  Ala Leu Cys 
    1175                 1180                 1185             


His Ser  Pro Pro Val Thr Gln  Thr Ile Ala Leu Cys  His Ser Pro 
    1190                 1195                 1200             


Pro Pro  Ile Gln Val Ser Ala  Leu His His Ser Pro  Pro Leu Val 
    1205                 1210                 1215             


Gln Ala  Thr Ala Leu His His  Ser Pro Pro Ser Ala  Gln Ala Ser 
    1220                 1225                 1230             


Ala Leu  Cys Tyr Ser Pro Pro  Leu Ala Gln Ala Ala  Ala Ile Ser 
    1235                 1240                 1245             


His Ser  Ser Pro Leu Pro Gln  Val Ile Ala Leu His  Arg Ser Gln 
    1250                 1255                 1260             


Ala Gln  Ser Ser Val Ser Leu  Gln Gln Gly Trp Val  Gln Gly Ala 
    1265                 1270                 1275             


Asp Gly  Leu Cys Ser Val Asp  Gln Gly Val Gln Gly  Ser Ala Thr 
    1280                 1285                 1290             


Ser Gln  Phe Tyr Thr Met Ser  Glu Arg Leu His Pro  Ser Asp Asp 
    1295                 1300                 1305             


Ser Ile  Lys Val Ile Pro Leu  Thr Thr Phe Thr Pro  Arg Gln Gln 
    1310                 1315                 1320             


Ala Arg  Pro Ser Arg Gly Asp  Ser Pro Ile Met Glu  Glu His Pro 
    1325                 1330                 1335             


Leu 
    


<210>  2222
<211>  1065
<212>  PRT
<213>  Homo sapiens

<400>  2222

Met Asp Leu Leu Ser Gly Thr Tyr Ile Phe Ala Val Leu Leu Ala Cys 
1               5                   10                  15      


Val Val Phe His Ser Gly Ala Gln Glu Lys Asn Tyr Thr Ile Arg Glu 
            20                  25                  30          


Glu Met Pro Glu Asn Val Leu Ile Gly Asp Leu Leu Lys Asp Leu Asn 
        35                  40                  45              


Leu Ser Leu Ile Pro Asn Lys Ser Leu Thr Thr Ala Met Gln Phe Lys 
    50                  55                  60                  


Leu Val Tyr Lys Thr Gly Asp Val Pro Leu Ile Arg Ile Glu Glu Asp 
65                  70                  75                  80  


Thr Gly Glu Ile Phe Thr Thr Gly Ala Arg Ile Asp Arg Glu Lys Leu 
                85                  90                  95      


Cys Ala Gly Ile Pro Arg Asp Glu His Cys Phe Tyr Glu Val Glu Val 
            100                 105                 110         


Ala Ile Leu Pro Asp Glu Ile Phe Arg Leu Val Lys Ile Arg Phe Leu 
        115                 120                 125             


Ile Glu Asp Ile Asn Asp Asn Ala Pro Leu Phe Pro Ala Thr Val Ile 
    130                 135                 140                 


Asn Ile Ser Ile Pro Glu Asn Ser Ala Ile Asn Ser Lys Tyr Thr Leu 
145                 150                 155                 160 


Pro Ala Ala Val Asp Pro Asp Val Gly Ile Asn Gly Val Gln Asn Tyr 
                165                 170                 175     


Glu Leu Ile Lys Ser Gln Asn Ile Phe Gly Leu Asp Val Ile Glu Thr 
            180                 185                 190         


Pro Glu Gly Asp Lys Met Pro Gln Leu Ile Val Gln Lys Glu Leu Asp 
        195                 200                 205             


Arg Glu Glu Lys Asp Thr Tyr Val Met Lys Val Lys Val Glu Asp Gly 
    210                 215                 220                 


Gly Phe Pro Gln Arg Ser Ser Thr Ala Ile Leu Gln Val Ser Val Thr 
225                 230                 235                 240 


Asp Thr Asn Asp Asn His Pro Val Phe Lys Glu Thr Glu Ile Glu Val 
                245                 250                 255     


Ser Ile Pro Glu Asn Ala Pro Val Gly Thr Ser Val Thr Gln Leu His 
            260                 265                 270         


Ala Thr Asp Ala Asp Ile Gly Glu Asn Ala Lys Ile His Phe Ser Phe 
        275                 280                 285             


Ser Asn Leu Val Ser Asn Ile Ala Arg Arg Leu Phe His Leu Asn Ala 
    290                 295                 300                 


Thr Thr Gly Leu Ile Thr Ile Lys Glu Pro Leu Asp Arg Glu Glu Thr 
305                 310                 315                 320 


Pro Asn His Lys Leu Leu Val Leu Ala Ser Asp Gly Gly Leu Met Pro 
                325                 330                 335     


Ala Arg Ala Met Val Leu Val Asn Val Thr Asp Val Asn Asp Asn Val 
            340                 345                 350         


Pro Ser Ile Asp Ile Arg Tyr Ile Val Asn Pro Val Asn Asp Thr Val 
        355                 360                 365             


Val Leu Ser Glu Asn Ile Pro Leu Asn Thr Lys Ile Ala Leu Ile Thr 
    370                 375                 380                 


Val Thr Asp Lys Asp Ala Asp His Asn Gly Arg Val Thr Cys Phe Thr 
385                 390                 395                 400 


Asp His Glu Ile Pro Phe Arg Leu Arg Pro Val Phe Ser Asn Gln Phe 
                405                 410                 415     


Leu Leu Glu Thr Ala Ala Tyr Leu Asp Tyr Glu Ser Thr Lys Glu Tyr 
            420                 425                 430         


Ala Ile Lys Leu Leu Ala Ala Asp Ala Gly Lys Pro Pro Leu Asn Gln 
        435                 440                 445             


Ser Ala Met Leu Phe Ile Lys Val Lys Asp Glu Asn Asp Asn Ala Pro 
    450                 455                 460                 


Val Phe Thr Gln Ser Phe Val Thr Val Ser Ile Pro Glu Asn Asn Ser 
465                 470                 475                 480 


Pro Gly Ile Gln Leu Thr Lys Val Ser Ala Met Asp Ala Asp Ser Gly 
                485                 490                 495     


Pro Asn Ala Lys Ile Asn Tyr Leu Leu Gly Pro Asp Ala Pro Pro Glu 
            500                 505                 510         


Phe Ser Leu Asp Cys Arg Thr Gly Met Leu Thr Val Val Lys Lys Leu 
        515                 520                 525             


Asp Arg Glu Lys Glu Asp Lys Tyr Leu Phe Thr Ile Leu Ala Lys Asp 
    530                 535                 540                 


Asn Gly Val Pro Pro Leu Thr Ser Asn Val Thr Val Phe Val Ser Ile 
545                 550                 555                 560 


Ile Asp Gln Asn Asp Asn Ser Pro Val Phe Thr His Asn Glu Tyr Asn 
                565                 570                 575     


Phe Tyr Val Pro Glu Asn Leu Pro Arg His Gly Thr Val Gly Leu Ile 
            580                 585                 590         


Thr Val Thr Asp Pro Asp Tyr Gly Asp Asn Ser Ala Val Thr Leu Ser 
        595                 600                 605             


Ile Leu Asp Glu Asn Asp Asp Phe Thr Ile Asp Ser Gln Thr Gly Val 
    610                 615                 620                 


Ile Arg Pro Asn Ile Ser Phe Asp Arg Glu Lys Gln Glu Ser Tyr Thr 
625                 630                 635                 640 


Phe Tyr Val Lys Ala Glu Asp Gly Gly Arg Val Ser Arg Ser Ser Ser 
                645                 650                 655     


Ala Lys Val Thr Ile Asn Val Val Asp Val Asn Asp Asn Lys Pro Val 
            660                 665                 670         


Phe Ile Val Pro Pro Ser Asn Cys Ser Tyr Glu Leu Val Leu Pro Ser 
        675                 680                 685             


Thr Asn Pro Gly Thr Val Val Phe Gln Val Ile Ala Val Asp Asn Asp 
    690                 695                 700                 


Thr Gly Met Asn Ala Glu Val Arg Tyr Ser Ile Val Gly Gly Asn Thr 
705                 710                 715                 720 


Arg Asp Leu Phe Ala Ile Asp Gln Glu Thr Gly Asn Ile Thr Leu Met 
                725                 730                 735     


Glu Lys Cys Asp Val Thr Asp Leu Gly Leu His Arg Val Leu Val Lys 
            740                 745                 750         


Ala Asn Asp Leu Gly Gln Pro Asp Ser Leu Phe Ser Val Val Ile Val 
        755                 760                 765             


Asn Leu Phe Val Asn Glu Ser Val Thr Asn Ala Thr Leu Ile Asn Glu 
    770                 775                 780                 


Leu Val Arg Lys Ser Thr Glu Ala Pro Val Thr Pro Asn Thr Glu Ile 
785                 790                 795                 800 


Ala Asp Val Ser Ser Pro Thr Ser Asp Tyr Val Lys Ile Leu Val Ala 
                805                 810                 815     


Ala Val Ala Gly Thr Ile Thr Val Val Val Val Ile Phe Ile Thr Ala 
            820                 825                 830         


Val Val Arg Cys Arg Gln Ala Pro His Leu Lys Ala Ala Gln Lys Asn 
        835                 840                 845             


Lys Gln Asn Ser Glu Trp Ala Thr Pro Asn Pro Glu Asn Arg Gln Met 
    850                 855                 860                 


Ile Met Met Lys Lys Lys Lys Lys Lys Lys Lys His Ser Pro Lys Asn 
865                 870                 875                 880 


Leu Leu Leu Asn Phe Val Thr Ile Glu Glu Thr Lys Ala Asp Asp Val 
                885                 890                 895     


Asp Ser Asp Gly Asn Arg Val Thr Leu Asp Leu Pro Ile Asp Leu Glu 
            900                 905                 910         


Glu Gln Thr Met Gly Lys Tyr Asn Trp Val Thr Thr Pro Thr Thr Phe 
        915                 920                 925             


Lys Pro Asp Ser Pro Asp Leu Ala Arg His Tyr Lys Ser Ala Ser Pro 
    930                 935                 940                 


Gln Pro Ala Phe Gln Ile Gln Pro Glu Thr Pro Leu Asn Ser Lys His 
945                 950                 955                 960 


His Ile Ile Gln Glu Leu Pro Leu Asp Asn Thr Phe Val Ala Cys Asp 
                965                 970                 975     


Ser Ile Ser Lys Cys Ser Ser Ser Ser Ser Asp Pro Tyr Ser Val Ser 
            980                 985                 990         


Asp Cys Gly Tyr Pro Val Thr Thr  Phe Glu Val Pro Val  Ser Val His 
        995                 1000                 1005             


Thr Arg  Pro Pro Met Lys Glu  Val Val Arg Ser Cys  Thr Pro Met 
    1010                 1015                 1020             


Lys Glu  Ser Thr Thr Met Glu  Ile Trp Ile His Pro  Gln Pro Gln 
    1025                 1030                 1035             


Arg Lys  Ser Glu Gly Lys Val  Ala Gly Lys Thr Val  Leu Thr Ser 
    1040                 1045                 1050             


Ser Ser  Pro Ser Ala Met Thr  Leu Ser Tyr Leu Asp  
    1055                 1060                 1065 


<210>  2223
<211>  1310
<212>  PRT
<213>  Homo sapiens

<400>  2223

Met Asp Leu Leu Ser Gly Thr Tyr Ile Phe Ala Val Leu Leu Ala Cys 
1               5                   10                  15      


Val Val Phe His Ser Gly Ala Gln Glu Lys Asn Tyr Thr Ile Arg Glu 
            20                  25                  30          


Glu Met Pro Glu Asn Val Leu Ile Gly Asp Leu Leu Lys Asp Leu Asn 
        35                  40                  45              


Leu Ser Leu Ile Pro Asn Lys Ser Leu Thr Thr Ala Met Gln Phe Lys 
    50                  55                  60                  


Leu Val Tyr Lys Thr Gly Asp Val Pro Leu Ile Arg Ile Glu Glu Asp 
65                  70                  75                  80  


Thr Gly Glu Ile Phe Thr Thr Gly Ala Arg Ile Asp Arg Glu Lys Leu 
                85                  90                  95      


Cys Ala Gly Ile Pro Arg Asp Glu His Cys Phe Tyr Glu Val Glu Val 
            100                 105                 110         


Ala Ile Leu Pro Asp Glu Ile Phe Arg Leu Val Lys Ile Arg Phe Leu 
        115                 120                 125             


Ile Glu Asp Ile Asn Asp Asn Ala Pro Leu Phe Pro Ala Thr Val Ile 
    130                 135                 140                 


Asn Ile Ser Ile Pro Glu Asn Ser Ala Ile Asn Ser Lys Tyr Thr Leu 
145                 150                 155                 160 


Pro Ala Ala Val Asp Pro Asp Val Gly Ile Asn Gly Val Gln Asn Tyr 
                165                 170                 175     


Glu Leu Ile Lys Ser Gln Asn Ile Phe Gly Leu Asp Val Ile Glu Thr 
            180                 185                 190         


Pro Glu Gly Asp Lys Met Pro Gln Leu Ile Val Gln Lys Glu Leu Asp 
        195                 200                 205             


Arg Glu Glu Lys Asp Thr Tyr Val Met Lys Val Lys Val Glu Asp Gly 
    210                 215                 220                 


Gly Phe Pro Gln Arg Ser Ser Thr Ala Ile Leu Gln Val Ser Val Thr 
225                 230                 235                 240 


Asp Thr Asn Asp Asn His Pro Val Phe Lys Glu Thr Glu Ile Glu Val 
                245                 250                 255     


Ser Ile Pro Glu Asn Ala Pro Val Gly Thr Ser Val Thr Gln Leu His 
            260                 265                 270         


Ala Thr Asp Ala Asp Ile Gly Glu Asn Ala Lys Ile His Phe Ser Phe 
        275                 280                 285             


Ser Asn Leu Val Ser Asn Ile Ala Arg Arg Leu Phe His Leu Asn Ala 
    290                 295                 300                 


Thr Thr Gly Leu Ile Thr Ile Lys Glu Pro Leu Asp Arg Glu Glu Thr 
305                 310                 315                 320 


Pro Asn His Lys Leu Leu Val Leu Ala Ser Asp Gly Gly Leu Met Pro 
                325                 330                 335     


Ala Arg Ala Met Val Leu Val Asn Val Thr Asp Val Asn Asp Asn Val 
            340                 345                 350         


Pro Ser Ile Asp Ile Arg Tyr Ile Val Asn Pro Val Asn Asp Thr Val 
        355                 360                 365             


Val Leu Ser Glu Asn Ile Pro Leu Asn Thr Lys Ile Ala Leu Ile Thr 
    370                 375                 380                 


Val Thr Asp Lys Asp Ala Asp His Asn Gly Arg Val Thr Cys Phe Thr 
385                 390                 395                 400 


Asp His Glu Ile Pro Phe Arg Leu Arg Pro Val Phe Ser Asn Gln Phe 
                405                 410                 415     


Leu Leu Glu Thr Ala Ala Tyr Leu Asp Tyr Glu Ser Thr Lys Glu Tyr 
            420                 425                 430         


Ala Ile Lys Leu Leu Ala Ala Asp Ala Gly Lys Pro Pro Leu Asn Gln 
        435                 440                 445             


Ser Ala Met Leu Phe Ile Lys Val Lys Asp Glu Asn Asp Asn Ala Pro 
    450                 455                 460                 


Val Phe Thr Gln Ser Phe Val Thr Val Ser Ile Pro Glu Asn Asn Ser 
465                 470                 475                 480 


Pro Gly Ile Gln Leu Thr Lys Val Ser Ala Met Asp Ala Asp Ser Gly 
                485                 490                 495     


Pro Asn Ala Lys Ile Asn Tyr Leu Leu Gly Pro Asp Ala Pro Pro Glu 
            500                 505                 510         


Phe Ser Leu Asp Cys Arg Thr Gly Met Leu Thr Val Val Lys Lys Leu 
        515                 520                 525             


Asp Arg Glu Lys Glu Asp Lys Tyr Leu Phe Thr Ile Leu Ala Lys Asp 
    530                 535                 540                 


Asn Gly Val Pro Pro Leu Thr Ser Asn Val Thr Val Phe Val Ser Ile 
545                 550                 555                 560 


Ile Asp Gln Asn Asp Asn Ser Pro Val Phe Thr His Asn Glu Tyr Asn 
                565                 570                 575     


Phe Tyr Val Pro Glu Asn Leu Pro Arg His Gly Thr Val Gly Leu Ile 
            580                 585                 590         


Thr Val Thr Asp Pro Asp Tyr Gly Asp Asn Ser Ala Val Thr Leu Ser 
        595                 600                 605             


Ile Leu Asp Glu Asn Asp Asp Phe Thr Ile Asp Ser Gln Thr Gly Val 
    610                 615                 620                 


Ile Arg Pro Asn Ile Ser Phe Asp Arg Glu Lys Gln Glu Ser Tyr Thr 
625                 630                 635                 640 


Phe Tyr Val Lys Ala Glu Asp Gly Gly Arg Val Ser Arg Ser Ser Ser 
                645                 650                 655     


Ala Lys Val Thr Ile Asn Val Val Asp Val Asn Asp Asn Lys Pro Val 
            660                 665                 670         


Phe Ile Val Pro Pro Ser Asn Cys Ser Tyr Glu Leu Val Leu Pro Ser 
        675                 680                 685             


Thr Asn Pro Gly Thr Val Val Phe Gln Val Ile Ala Val Asp Asn Asp 
    690                 695                 700                 


Thr Gly Met Asn Ala Glu Val Arg Tyr Ser Ile Val Gly Gly Asn Thr 
705                 710                 715                 720 


Arg Asp Leu Phe Ala Ile Asp Gln Glu Thr Gly Asn Ile Thr Leu Met 
                725                 730                 735     


Glu Lys Cys Asp Val Thr Asp Leu Gly Leu His Arg Val Leu Val Lys 
            740                 745                 750         


Ala Asn Asp Leu Gly Gln Pro Asp Ser Leu Phe Ser Val Val Ile Val 
        755                 760                 765             


Asn Leu Phe Val Asn Glu Ser Val Thr Asn Ala Thr Leu Ile Asn Glu 
    770                 775                 780                 


Leu Val Arg Lys Ser Thr Glu Ala Pro Val Thr Pro Asn Thr Glu Ile 
785                 790                 795                 800 


Ala Asp Val Ser Ser Pro Thr Ser Asp Tyr Val Lys Ile Leu Val Ala 
                805                 810                 815     


Ala Val Ala Gly Thr Ile Thr Val Val Val Val Ile Phe Ile Thr Ala 
            820                 825                 830         


Val Val Arg Cys Arg Gln Ala Pro His Leu Lys Ala Ala Gln Lys Asn 
        835                 840                 845             


Lys Gln Asn Ser Glu Trp Ala Thr Pro Asn Pro Glu Asn Arg Gln Met 
    850                 855                 860                 


Ile Met Met Lys Lys Lys Lys Lys Lys Lys Lys His Ser Pro Lys Asn 
865                 870                 875                 880 


Leu Leu Leu Asn Phe Val Thr Ile Glu Glu Thr Lys Ala Asp Asp Val 
                885                 890                 895     


Asp Ser Asp Gly Asn Arg Val Thr Leu Asp Leu Pro Ile Asp Leu Glu 
            900                 905                 910         


Glu Gln Thr Met Gly Lys Tyr Asn Trp Val Thr Thr Pro Thr Thr Phe 
        915                 920                 925             


Lys Pro Asp Ser Pro Asp Leu Ala Arg His Tyr Lys Ser Ala Ser Pro 
    930                 935                 940                 


Gln Pro Ala Phe Gln Ile Gln Pro Glu Thr Pro Leu Asn Ser Lys His 
945                 950                 955                 960 


His Ile Ile Gln Glu Leu Pro Leu Asp Asn Thr Phe Val Ala Cys Asp 
                965                 970                 975     


Ser Ile Ser Lys Cys Ser Ser Ser Ser Ser Asp Pro Tyr Ser Val Ser 
            980                 985                 990         


Asp Cys Gly Tyr Pro Val Thr Thr  Phe Glu Val Pro Val  Ser Val His 
        995                 1000                 1005             


Thr Arg  Pro Ser Gln Arg Arg  Val Thr Phe His Leu  Pro Glu Gly 
    1010                 1015                 1020             


Ser Gln  Glu Ser Ser Ser Asp  Gly Gly Leu Gly Asp  His Asp Ala 
    1025                 1030                 1035             


Gly Ser  Leu Thr Ser Thr Ser  His Gly Leu Pro Leu  Gly Tyr Pro 
    1040                 1045                 1050             


Gln Glu  Glu Tyr Phe Asp Arg  Ala Thr Pro Ser Asn  Arg Thr Glu 
    1055                 1060                 1065             


Gly Asp  Gly Asn Ser Asp Pro  Glu Ser Thr Phe Ile  Pro Gly Leu 
    1070                 1075                 1080             


Lys Lys  Ala Ala Glu Ile Thr  Val Gln Pro Thr Val  Glu Glu Ala 
    1085                 1090                 1095             


Ser Asp  Asn Cys Thr Gln Glu  Cys Leu Ile Tyr Gly  His Ser Asp 
    1100                 1105                 1110             


Ala Cys  Trp Met Pro Ala Ser  Leu Asp His Ser Ser  Ser Ser Gln 
    1115                 1120                 1125             


Ala Gln  Ala Ser Ala Leu Cys  His Ser Pro Pro Leu  Ser Gln Ala 
    1130                 1135                 1140             


Ser Thr  Gln His His Ser Pro  Arg Val Thr Gln Thr  Ile Ala Leu 
    1145                 1150                 1155             


Cys His  Ser Pro Pro Val Thr  Gln Thr Ile Ala Leu  Cys His Ser 
    1160                 1165                 1170             


Pro Pro  Pro Ile Gln Val Ser  Ala Leu His His Ser  Pro Pro Leu 
    1175                 1180                 1185             


Val Gln  Ala Thr Ala Leu His  His Ser Pro Pro Ser  Ala Gln Ala 
    1190                 1195                 1200             


Ser Ala  Leu Cys Tyr Ser Pro  Pro Leu Ala Gln Ala  Ala Ala Ile 
    1205                 1210                 1215             


Ser His  Ser Ser Pro Leu Pro  Gln Val Ile Ala Leu  His Arg Ser 
    1220                 1225                 1230             


Gln Ala  Gln Ser Ser Val Ser  Leu Gln Gln Gly Trp  Val Gln Gly 
    1235                 1240                 1245             


Ala Asp  Gly Leu Cys Ser Val  Asp Gln Gly Val Gln  Gly Ser Ala 
    1250                 1255                 1260             


Thr Ser  Gln Phe Tyr Thr Met  Ser Glu Arg Leu His  Pro Ser Asp 
    1265                 1270                 1275             


Asp Ser  Ile Lys Val Ile Pro  Leu Thr Thr Phe Thr  Pro Arg Gln 
    1280                 1285                 1290             


Gln Ala  Arg Pro Ser Arg Gly  Asp Ser Pro Ile Met  Glu Glu His 
    1295                 1300                 1305             


Pro Leu  
    1310 


<210>  2224
<211>  1329
<212>  PRT
<213>  Homo sapiens

<400>  2224

Met Asp Leu Leu Ser Gly Thr Tyr Ile Phe Ala Val Leu Leu Ala Cys 
1               5                   10                  15      


Val Val Phe His Ser Gly Ala Gln Glu Lys Asn Tyr Thr Ile Arg Glu 
            20                  25                  30          


Glu Met Pro Glu Asn Val Leu Ile Gly Asp Leu Leu Lys Asp Leu Asn 
        35                  40                  45              


Leu Ser Leu Ile Pro Asn Lys Ser Leu Thr Thr Ala Met Gln Phe Lys 
    50                  55                  60                  


Leu Val Tyr Lys Thr Gly Asp Val Pro Leu Ile Arg Ile Glu Glu Asp 
65                  70                  75                  80  


Thr Gly Glu Ile Phe Thr Thr Gly Ala Arg Ile Asp Arg Glu Lys Leu 
                85                  90                  95      


Cys Ala Gly Ile Pro Arg Asp Glu His Cys Phe Tyr Glu Val Glu Val 
            100                 105                 110         


Ala Ile Leu Pro Asp Glu Ile Phe Arg Leu Val Lys Ile Arg Phe Leu 
        115                 120                 125             


Ile Glu Asp Ile Asn Asp Asn Ala Pro Leu Phe Pro Ala Thr Val Ile 
    130                 135                 140                 


Asn Ile Ser Ile Pro Glu Asn Ser Ala Ile Asn Ser Lys Tyr Thr Leu 
145                 150                 155                 160 


Pro Ala Ala Val Asp Pro Asp Val Gly Ile Asn Gly Val Gln Asn Tyr 
                165                 170                 175     


Glu Leu Ile Lys Ser Gln Asn Ile Phe Gly Leu Asp Val Ile Glu Thr 
            180                 185                 190         


Pro Glu Gly Asp Lys Met Pro Gln Leu Ile Val Gln Lys Glu Leu Asp 
        195                 200                 205             


Arg Glu Glu Lys Asp Thr Tyr Val Met Lys Val Lys Val Glu Asp Gly 
    210                 215                 220                 


Gly Phe Pro Gln Arg Ser Ser Thr Ala Ile Leu Gln Val Ser Val Thr 
225                 230                 235                 240 


Asp Thr Asn Asp Asn His Pro Val Phe Lys Glu Thr Glu Ile Glu Val 
                245                 250                 255     


Ser Ile Pro Glu Asn Ala Pro Val Gly Thr Ser Val Thr Gln Leu His 
            260                 265                 270         


Ala Thr Asp Ala Asp Ile Gly Glu Asn Ala Lys Ile His Phe Ser Phe 
        275                 280                 285             


Ser Asn Leu Val Ser Asn Ile Ala Arg Arg Leu Phe His Leu Asn Ala 
    290                 295                 300                 


Thr Thr Gly Leu Ile Thr Ile Lys Glu Pro Leu Asp Arg Glu Glu Thr 
305                 310                 315                 320 


Pro Asn His Lys Leu Leu Val Leu Ala Ser Asp Gly Gly Leu Met Pro 
                325                 330                 335     


Ala Arg Ala Met Val Leu Val Asn Val Thr Asp Val Asn Asp Asn Val 
            340                 345                 350         


Pro Ser Ile Asp Ile Arg Tyr Ile Val Asn Pro Val Asn Asp Thr Val 
        355                 360                 365             


Val Leu Ser Glu Asn Ile Pro Leu Asn Thr Lys Ile Ala Leu Ile Thr 
    370                 375                 380                 


Val Thr Asp Lys Asp Ala Asp His Asn Gly Arg Val Thr Cys Phe Thr 
385                 390                 395                 400 


Asp His Glu Ile Pro Phe Arg Leu Arg Pro Val Phe Ser Asn Gln Phe 
                405                 410                 415     


Leu Leu Glu Thr Ala Ala Tyr Leu Asp Tyr Glu Ser Thr Lys Glu Tyr 
            420                 425                 430         


Ala Ile Lys Leu Leu Ala Ala Asp Ala Gly Lys Pro Pro Leu Asn Gln 
        435                 440                 445             


Ser Ala Met Leu Phe Ile Lys Val Lys Asp Glu Asn Asp Asn Ala Pro 
    450                 455                 460                 


Val Phe Thr Gln Ser Phe Val Thr Val Ser Ile Pro Glu Asn Asn Ser 
465                 470                 475                 480 


Pro Gly Ile Gln Leu Thr Lys Val Ser Ala Met Asp Ala Asp Ser Gly 
                485                 490                 495     


Pro Asn Ala Lys Ile Asn Tyr Leu Leu Gly Pro Asp Ala Pro Pro Glu 
            500                 505                 510         


Phe Ser Leu Asp Cys Arg Thr Gly Met Leu Thr Val Val Lys Lys Leu 
        515                 520                 525             


Asp Arg Glu Lys Glu Asp Lys Tyr Leu Phe Thr Ile Leu Ala Lys Asp 
    530                 535                 540                 


Asn Gly Val Pro Pro Leu Thr Ser Asn Val Thr Val Phe Val Ser Ile 
545                 550                 555                 560 


Ile Asp Gln Asn Asp Asn Ser Pro Val Phe Thr His Asn Glu Tyr Asn 
                565                 570                 575     


Phe Tyr Val Pro Glu Asn Leu Pro Arg His Gly Thr Val Gly Leu Ile 
            580                 585                 590         


Thr Val Thr Asp Pro Asp Tyr Gly Asp Asn Ser Ala Val Thr Leu Ser 
        595                 600                 605             


Ile Leu Asp Glu Asn Asp Asp Phe Thr Ile Asp Ser Gln Thr Gly Val 
    610                 615                 620                 


Ile Arg Pro Asn Ile Ser Phe Asp Arg Glu Lys Gln Glu Ser Tyr Thr 
625                 630                 635                 640 


Phe Tyr Val Lys Ala Glu Asp Gly Gly Arg Val Ser Arg Ser Ser Ser 
                645                 650                 655     


Ala Lys Val Thr Ile Asn Val Val Asp Val Asn Asp Asn Lys Pro Val 
            660                 665                 670         


Phe Ile Val Pro Pro Ser Asn Cys Ser Tyr Glu Leu Val Leu Pro Ser 
        675                 680                 685             


Thr Asn Pro Gly Thr Val Val Phe Gln Val Ile Ala Val Asp Asn Asp 
    690                 695                 700                 


Thr Gly Met Asn Ala Glu Val Arg Tyr Ser Ile Val Gly Gly Asn Thr 
705                 710                 715                 720 


Arg Asp Leu Phe Ala Ile Asp Gln Glu Thr Gly Asn Ile Thr Leu Met 
                725                 730                 735     


Glu Lys Cys Asp Val Thr Asp Leu Gly Leu His Arg Val Leu Val Lys 
            740                 745                 750         


Ala Asn Asp Leu Gly Gln Pro Asp Ser Leu Phe Ser Val Val Ile Val 
        755                 760                 765             


Asn Leu Phe Val Asn Glu Ser Val Thr Asn Ala Thr Leu Ile Asn Glu 
    770                 775                 780                 


Leu Val Arg Lys Ser Thr Glu Ala Pro Val Thr Pro Asn Thr Glu Ile 
785                 790                 795                 800 


Ala Asp Val Ser Ser Pro Thr Ser Asp Tyr Val Lys Ile Leu Val Ala 
                805                 810                 815     


Ala Val Ala Gly Thr Ile Thr Val Val Val Val Ile Phe Ile Thr Ala 
            820                 825                 830         


Val Val Arg Cys Arg Gln Ala Pro His Leu Lys Ala Ala Gln Lys Asn 
        835                 840                 845             


Lys Gln Asn Ser Glu Trp Ala Thr Pro Asn Pro Glu Asn Arg Gln Met 
    850                 855                 860                 


Ile Met Met Lys Lys Lys Lys Lys Lys Lys Lys His Ser Pro Lys Asn 
865                 870                 875                 880 


Leu Leu Leu Asn Phe Val Thr Ile Glu Glu Thr Lys Ala Asp Asp Val 
                885                 890                 895     


Asp Ser Asp Gly Asn Arg Val Thr Leu Asp Leu Pro Ile Asp Leu Glu 
            900                 905                 910         


Glu Gln Thr Met Gly Lys Tyr Asn Trp Val Thr Thr Pro Thr Thr Phe 
        915                 920                 925             


Lys Pro Asp Ser Pro Asp Leu Ala Arg His Tyr Lys Ser Ala Ser Pro 
    930                 935                 940                 


Gln Pro Ala Phe Gln Ile Gln Pro Glu Thr Pro Leu Asn Ser Lys His 
945                 950                 955                 960 


His Ile Ile Gln Glu Leu Pro Leu Asp Asn Thr Phe Val Ala Cys Asp 
                965                 970                 975     


Ser Ile Ser Lys Cys Ser Ser Ser Ser Ser Asp Pro Tyr Ser Val Ser 
            980                 985                 990         


Asp Cys Gly Tyr Pro Val Thr Thr  Phe Glu Val Pro Val  Ser Val His 
        995                 1000                 1005             


Thr Arg  Pro Pro Met Lys Glu  Val Val Arg Ser Cys  Thr Pro Met 
    1010                 1015                 1020             


Lys Glu  Ser Thr Thr Met Glu  Ile Trp Ile His Pro  Gln Pro Gln 
    1025                 1030                 1035             


Ser Gln  Arg Arg Val Thr Phe  His Leu Pro Glu Gly  Ser Gln Glu 
    1040                 1045                 1050             


Ser Ser  Ser Asp Gly Gly Leu  Gly Asp His Asp Ala  Gly Ser Leu 
    1055                 1060                 1065             


Thr Ser  Thr Ser His Gly Leu  Pro Leu Gly Tyr Pro  Gln Glu Glu 
    1070                 1075                 1080             


Tyr Phe  Asp Arg Ala Thr Pro  Ser Asn Arg Thr Glu  Gly Asp Gly 
    1085                 1090                 1095             


Asn Ser  Asp Pro Glu Ser Thr  Ala Glu Ile Thr Val  Gln Pro Thr 
    1100                 1105                 1110             


Val Glu  Glu Ala Ser Asp Asn  Cys Thr Gln Glu Cys  Leu Ile Tyr 
    1115                 1120                 1125             


Gly His  Ser Asp Ala Cys Trp  Met Pro Ala Ser Leu  Asp His Ser 
    1130                 1135                 1140             


Ser Ser  Ser Gln Ala Gln Ala  Ser Ala Leu Cys His  Ser Pro Pro 
    1145                 1150                 1155             


Leu Ser  Gln Ala Ser Thr Gln  His His Ser Pro Arg  Val Thr Gln 
    1160                 1165                 1170             


Thr Ile  Ala Leu Cys His Ser  Pro Pro Val Thr Gln  Thr Ile Ala 
    1175                 1180                 1185             


Leu Cys  His Ser Pro Pro Pro  Ile Gln Val Ser Ala  Leu His His 
    1190                 1195                 1200             


Ser Pro  Pro Leu Val Gln Ala  Thr Ala Leu His His  Ser Pro Pro 
    1205                 1210                 1215             


Ser Ala  Gln Ala Ser Ala Leu  Cys Tyr Ser Pro Pro  Leu Ala Gln 
    1220                 1225                 1230             


Ala Ala  Ala Ile Ser His Ser  Ser Pro Leu Pro Gln  Val Ile Ala 
    1235                 1240                 1245             


Leu His  Arg Ser Gln Ala Gln  Ser Ser Val Ser Leu  Gln Gln Gly 
    1250                 1255                 1260             


Trp Val  Gln Gly Ala Asp Gly  Leu Cys Ser Val Asp  Gln Gly Val 
    1265                 1270                 1275             


Gln Gly  Ser Ala Thr Ser Gln  Phe Tyr Thr Met Ser  Glu Arg Leu 
    1280                 1285                 1290             


His Pro  Ser Asp Asp Ser Ile  Lys Val Ile Pro Leu  Thr Thr Phe 
    1295                 1300                 1305             


Thr Pro  Arg Gln Gln Ala Arg  Pro Ser Arg Gly Asp  Ser Pro Ile 
    1310                 1315                 1320             


Met Glu  Glu His Pro Leu 
    1325                 


<210>  2225
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  2225

Met Arg Arg Cys Ser Leu Cys Ala Phe Asp Ala Ala Arg Gly Pro Arg 
1               5                   10                  15      


Arg Leu Met Arg Val Gly Leu Ala Leu Ile Leu Val Gly His Val Asn 
            20                  25                  30          


Leu Leu Leu Gly Ala Val Leu His Gly Thr Val Leu Arg His Val Ala 
        35                  40                  45              


Asn Pro Arg Gly Ala Val Thr Pro Glu Tyr Thr Val Ala Asn Val Ile 
    50                  55                  60                  


Ser Val Gly Ser Gly Leu Leu Ser Val Ser Val Gly Leu Val Ala Leu 
65                  70                  75                  80  


Leu Ala Ser Arg Asn Leu Leu Arg Pro Pro Leu His Trp Val Leu Leu 
                85                  90                  95      


Ala Leu Ala Leu Val Asn Leu Leu Leu Ser Val Ala Cys Ser Leu Gly 
            100                 105                 110         


Leu Leu Leu Ala Val Ser Leu Thr Val Ala Asn Gly Gly Arg Arg Leu 
        115                 120                 125             


Ile Ala Asp Cys His Pro Gly Leu Leu Asp Pro Leu Val Pro Leu Asp 
    130                 135                 140                 


Glu Gly Pro Gly His Thr Asp Cys Pro Phe Asp Pro Thr Arg Ile Tyr 
145                 150                 155                 160 


Asp Thr Ala Leu Ala Leu Trp Ile Pro Ser Leu Leu Met Ser Ala Gly 
                165                 170                 175     


Glu Ala Ala Leu Ser Gly Tyr Cys Cys Val Ala Ala Leu Thr Leu Arg 
            180                 185                 190         


Gly Val Gly Pro Cys Arg Lys Asp Gly Leu Gln Gly Gln Leu Glu Glu 
        195                 200                 205             


Met Thr Glu Leu Glu Ser Pro Lys Cys Lys Arg Gln Glu Asn Glu Gln 
    210                 215                 220                 


Leu Leu Asp Gln Asn Gln Glu Ile Arg Ala Ser Gln Arg Ser Trp Val 
225                 230                 235                 240 


<210>  2226
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  2226

Met Arg Lys Ile Arg Ala Asn Ala Ile Ala Ile Leu Thr Val Ala Trp 
1               5                   10                  15      


Ile Leu Gly Thr Phe Tyr Tyr Leu Trp Gln Asp Asn Arg Ala His Ala 
            20                  25                  30          


Ala Ser Ser Gly Gly Arg Gly Ala Gln Arg Ala Gly Arg Arg Ser Glu 
        35                  40                  45              


Gln Leu Arg Glu Asp Arg Thr Ile Pro Leu Ile Val Thr Gly Thr Pro 
    50                  55                  60                  


Ser Lys Gly Phe Asp Glu Lys Ala Tyr Leu Ser Ala Lys Gln Leu Lys 
65                  70                  75                  80  


Ala Gly Glu Asp Pro Tyr Arg Gln His Ala Phe Asn Gln Leu Glu Ser 
                85                  90                  95      


Asp Lys Leu Ser Pro Asp Arg Pro Ile Arg Asp Thr Arg His Tyr Ser 
            100                 105                 110         


Cys Pro Ser Val Ser Tyr Ser Ser Asp Leu Pro Ala Thr Ser Val Ile 
        115                 120                 125             


Ile Thr Phe His Asn Glu Ala Arg Ser Thr Leu Leu Arg Thr Val Lys 
    130                 135                 140                 


Ser Val Leu Asn Arg Thr Pro Ala Asn Leu Ile Gln Glu Ile Ile Leu 
145                 150                 155                 160 


Val Asp Asp Phe Ser Ser Asp Pro Glu Asp Cys Leu Leu Leu Thr Arg 
                165                 170                 175     


Ile Pro Lys Val Lys Cys Leu Arg Asn Asp Arg Arg Glu Gly Leu Ile 
            180                 185                 190         


Arg Ser Arg Val Arg Gly Ala Asp Val Ala Ala Ala Thr Val Leu Thr 
        195                 200                 205             


Phe Leu Asp Ser His Cys Glu Val Asn Thr Glu Trp Leu Pro Pro Met 
    210                 215                 220                 


Leu Gln Arg Val Lys Glu Asp His Thr Arg Val Val Ser Pro Ile Ile 
225                 230                 235                 240 


Asp Val Ile Ser Leu Asp Asn Phe Ala Tyr Leu Ala Ala Ser Ala Asp 
                245                 250                 255     


Leu Arg Gly Gly Phe Asp Trp Ser Leu His Phe Lys Trp Glu Gln Ile 
            260                 265                 270         


Pro Leu Glu Gln Lys Met Thr Arg Thr Asp Pro Thr Arg Pro Ile Arg 
        275                 280                 285             


Thr Pro Val Ile Ala Gly Gly Ile Phe Val Ile Asp Lys Ser Trp Phe 
    290                 295                 300                 


Asn His Leu Gly Lys Tyr Asp Ala Gln Met Asp Ile Trp Gly Gly Glu 
305                 310                 315                 320 


Asn Phe Glu Leu Ser Phe Arg Val Trp Met Cys Gly Gly Ser Leu Glu 
                325                 330                 335     


Ile Val Pro Cys Ser Arg Val Gly His Val Phe Arg Lys Arg His Pro 
            340                 345                 350         


Tyr Asn Phe Pro Glu Gly Asn Ala Leu Thr Tyr Ile Arg Asn Thr Lys 
        355                 360                 365             


Arg Thr Ala Glu Val Trp Met Asp Glu Tyr Lys Gln Tyr Tyr Tyr Glu 
    370                 375                 380                 


Ala Arg Pro Ser Ala Ile Gly Lys Ala Phe Gly Ser Val Ala Thr Arg 
385                 390                 395                 400 


Ile Glu Gln Arg Lys Lys Met Asn Cys Lys Ser Phe Arg Trp Tyr Leu 
                405                 410                 415     


Glu Asn Val Tyr Pro Glu Leu Thr Val Pro Val Lys Glu Ala Leu Pro 
            420                 425                 430         


Gly Ile Ile Lys Gln Gly Val Asn Cys Leu Glu Ser Gln Gly Gln Asn 
        435                 440                 445             


Thr Ala Gly Asp Phe Leu Leu Gly Met Gly Ile Cys Arg Gly Ser Ala 
    450                 455                 460                 


Lys Asn Pro Gln Pro Ala Gln Ala Trp Leu Phe Ser Asp His Leu Ile 
465                 470                 475                 480 


Gln Gln Gln Gly Lys Cys Leu Ala Ala Thr Ser Thr Leu Met Ser Ser 
                485                 490                 495     


Pro Gly Ser Pro Val Ile Leu Gln Met Cys Asn Pro Arg Glu Gly Lys 
            500                 505                 510         


Gln Lys Trp Arg Arg Lys Gly Ser Phe Ile Gln His Ser Val Ser Gly 
        515                 520                 525             


Leu Cys Leu Glu Thr Lys Pro Ala Gln Leu Val Thr Ser Lys Cys Gln 
    530                 535                 540                 


Ala Asp Ala Gln Ala Gln Gln Trp Gln Leu Leu Pro His Thr 
545                 550                 555             


<210>  2227
<211>  1063
<212>  PRT
<213>  Homo sapiens

<400>  2227

Met Thr Arg Leu Gly Trp Pro Ser Pro Cys Cys Ala Arg Lys Gln Cys 
1               5                   10                  15      


Ser Glu Gly Arg Thr Tyr Ser Asn Ala Val Ile Ser Pro Asn Leu Glu 
            20                  25                  30          


Thr Thr Arg Ile Met Arg Val Ser His Thr Phe Pro Val Val Asp Cys 
        35                  40                  45              


Thr Ala Ala Cys Cys Asp Leu Ser Ser Cys Asp Leu Ala Trp Trp Phe 
    50                  55                  60                  


Glu Gly Arg Cys Tyr Leu Val Ser Cys Pro His Lys Glu Asn Cys Glu 
65                  70                  75                  80  


Pro Lys Lys Met Gly Pro Ile Arg Ser Tyr Leu Thr Phe Val Leu Arg 
                85                  90                  95      


Pro Val Gln Arg Pro Ala Gln Leu Leu Asp Tyr Gly Asp Met Met Leu 
            100                 105                 110         


Asn Arg Gly Ser Pro Ser Gly Ile Trp Gly Asp Ser Pro Glu Asp Ile 
        115                 120                 125             


Arg Lys Asp Leu Thr Phe Leu Gly Lys Asp Trp Gly Leu Glu Glu Met 
    130                 135                 140                 


Ser Glu Tyr Ser Asp Asp Tyr Arg Glu Leu Glu Lys Asp Leu Leu Gln 
145                 150                 155                 160 


Pro Ser Gly Lys Gln Glu Pro Arg Gly Ser Ala Glu Tyr Thr Asp Trp 
                165                 170                 175     


Gly Leu Leu Pro Gly Ser Glu Gly Ala Phe Asn Ser Ser Val Gly Asp 
            180                 185                 190         


Ser Pro Ala Val Pro Ala Glu Thr Gln Gln Asp Pro Glu Leu His Tyr 
        195                 200                 205             


Leu Asn Glu Ser Ala Ser Thr Pro Ala Pro Lys Leu Pro Glu Arg Ser 
    210                 215                 220                 


Val Leu Leu Pro Leu Pro Thr Thr Pro Ser Ser Gly Glu Val Leu Glu 
225                 230                 235                 240 


Lys Glu Lys Ala Ser Gln Leu Gln Glu Gln Ser Ser Asn Ser Ser Gly 
                245                 250                 255     


Lys Glu Val Leu Met Pro Ser His Ser Leu Pro Pro Ala Ser Leu Glu 
            260                 265                 270         


Leu Ser Ser Val Thr Val Glu Lys Ser Pro Val Leu Thr Val Thr Pro 
        275                 280                 285             


Gly Ser Thr Glu His Ser Ile Pro Thr Pro Pro Thr Ser Ala Ala Pro 
    290                 295                 300                 


Ser Glu Ser Thr Pro Ser Glu Leu Pro Ile Ser Pro Thr Thr Ala Pro 
305                 310                 315                 320 


Arg Thr Val Lys Glu Leu Thr Val Ser Ala Gly Asp Asn Leu Ile Ile 
                325                 330                 335     


Thr Leu Pro Asp Asn Glu Val Glu Leu Lys Ala Phe Val Ala Pro Ala 
            340                 345                 350         


Pro Pro Val Glu Thr Thr Tyr Asn Tyr Glu Trp Asn Leu Ile Ser His 
        355                 360                 365             


Pro Thr Asp Tyr Gln Gly Glu Ile Lys Gln Gly His Lys Gln Thr Leu 
    370                 375                 380                 


Asn Leu Ser Gln Leu Ser Val Gly Leu Tyr Val Phe Lys Val Thr Val 
385                 390                 395                 400 


Ser Ser Glu Asn Ala Phe Gly Glu Gly Phe Val Asn Val Thr Val Lys 
                405                 410                 415     


Pro Ala Arg Arg Val Asn Leu Pro Pro Val Ala Val Val Ser Pro Gln 
            420                 425                 430         


Leu Gln Glu Leu Thr Leu Pro Leu Thr Ser Ala Leu Ile Asp Gly Ser 
        435                 440                 445             


Gln Ser Thr Asp Asp Thr Glu Ile Val Ser Tyr His Trp Glu Glu Ile 
    450                 455                 460                 


Asn Gly Pro Phe Ile Glu Glu Lys Thr Ser Val Asp Ser Pro Val Leu 
465                 470                 475                 480 


Arg Leu Ser Asn Leu Asp Pro Gly Asn Tyr Ser Phe Arg Leu Thr Val 
                485                 490                 495     


Thr Asp Ser Asp Gly Ala Thr Asn Ser Thr Thr Ala Ala Leu Ile Val 
            500                 505                 510         


Asn Asn Ala Val Asp Tyr Pro Pro Val Ala Asn Ala Gly Pro Asn His 
        515                 520                 525             


Thr Ile Thr Leu Pro Gln Asn Ser Ile Thr Leu Asn Gly Asn Gln Ser 
    530                 535                 540                 


Ser Asp Asp His Gln Ile Val Leu Tyr Glu Trp Ser Leu Gly Pro Gly 
545                 550                 555                 560 


Ser Glu Gly Lys His Val Val Met Gln Gly Val Gln Thr Pro Tyr Leu 
                565                 570                 575     


His Leu Ser Ala Met Gln Glu Gly Asp Tyr Thr Phe Gln Leu Lys Val 
            580                 585                 590         


Thr Asp Ser Ser Arg Gln Gln Ser Thr Ala Val Val Thr Val Ile Val 
        595                 600                 605             


Gln Pro Glu Asn Asn Arg Pro Pro Val Ala Val Ala Gly Pro Asp Lys 
    610                 615                 620                 


Glu Leu Ile Phe Pro Val Glu Ser Ala Thr Leu Asp Gly Ser Ser Ser 
625                 630                 635                 640 


Ser Asp Asp His Gly Ile Val Phe Tyr His Trp Glu His Val Arg Gly 
                645                 650                 655     


Pro Ser Ala Val Glu Met Glu Asn Ile Asp Lys Ala Ile Ala Thr Val 
            660                 665                 670         


Thr Gly Leu Gln Val Gly Thr Tyr His Phe Arg Leu Thr Val Lys Asp 
        675                 680                 685             


Gln Gln Gly Leu Ser Ser Thr Ser Thr Leu Thr Val Ala Val Lys Lys 
    690                 695                 700                 


Glu Asn Asn Ser Pro Pro Arg Ala Arg Ala Gly Gly Arg His Val Leu 
705                 710                 715                 720 


Val Leu Pro Asn Asn Ser Ile Thr Leu Asp Gly Ser Arg Ser Thr Asp 
                725                 730                 735     


Asp Gln Arg Ile Val Ser Tyr Leu Trp Ile Arg Asp Gly Gln Ser Pro 
            740                 745                 750         


Ala Ala Gly Asp Val Ile Asp Gly Ser Asp His Ser Val Ala Leu Gln 
        755                 760                 765             


Leu Thr Asn Leu Val Glu Gly Val Tyr Thr Phe His Leu Arg Val Thr 
    770                 775                 780                 


Asp Ser Gln Gly Ala Ser Asp Thr Asp Thr Ala Thr Val Glu Val Gln 
785                 790                 795                 800 


Pro Asp Pro Arg Lys Ser Gly Leu Val Glu Leu Thr Leu Gln Val Gly 
                805                 810                 815     


Val Gly Gln Leu Thr Glu Gln Arg Lys Asp Thr Leu Val Arg Gln Leu 
            820                 825                 830         


Ala Val Leu Leu Asn Val Leu Asp Ser Asp Ile Lys Val Gln Lys Ile 
        835                 840                 845             


Arg Ala His Ser Asp Leu Ser Thr Val Ile Val Phe Tyr Val Gln Ser 
    850                 855                 860                 


Arg Pro Pro Phe Lys Val Leu Lys Ala Ala Glu Val Ala Arg Asn Leu 
865                 870                 875                 880 


His Met Arg Leu Ser Lys Glu Lys Ala Asp Phe Leu Leu Phe Lys Val 
                885                 890                 895     


Leu Arg Val Asp Thr Ala Gly Cys Leu Leu Lys Cys Ser Gly His Gly 
            900                 905                 910         


His Cys Asp Pro Leu Thr Lys Arg Cys Ile Cys Ser His Leu Trp Met 
        915                 920                 925             


Glu Asn Leu Ile Gln Arg Tyr Ile Trp Asp Gly Glu Ser Asn Cys Glu 
    930                 935                 940                 


Trp Ser Ile Phe Tyr Val Thr Val Leu Ala Phe Thr Leu Ile Val Leu 
945                 950                 955                 960 


Thr Gly Gly Phe Thr Trp Leu Cys Ile Cys Cys Cys Lys Arg Gln Lys 
                965                 970                 975     


Arg Thr Lys Ile Arg Lys Lys Thr Lys Tyr Thr Ile Leu Asp Asn Met 
            980                 985                 990         


Asp Glu Gln Glu Arg Met Glu Leu  Arg Pro Lys Tyr Gly  Ile Lys His 
        995                 1000                 1005             


Arg Ser  Thr Glu His Asn Ser  Ser Leu Met Val Ser  Glu Ser Glu 
    1010                 1015                 1020             


Phe Asp  Ser Asp Gln Asp Thr  Ile Phe Ser Arg Glu  Lys Met Glu 
    1025                 1030                 1035             


Arg Gly  Asn Pro Lys Val Ser  Met Asn Gly Ser Ile  Arg Asn Gly 
    1040                 1045                 1050             


Ala Ser  Phe Ser Tyr Cys Ser  Lys Asp Arg 
    1055                 1060             


<210>  2228
<211>  1072
<212>  PRT
<213>  Homo sapiens

<400>  2228

Met Ala Pro Pro Thr Gly Val Leu Ser Ser Leu Leu Leu Leu Val Thr 
1               5                   10                  15      


Ile Ala Gly Cys Ala Arg Lys Gln Cys Ser Glu Gly Arg Thr Tyr Ser 
            20                  25                  30          


Asn Ala Val Ile Ser Pro Asn Leu Glu Thr Thr Arg Ile Met Arg Val 
        35                  40                  45              


Ser His Thr Phe Pro Val Val Asp Cys Thr Ala Ala Cys Cys Asp Leu 
    50                  55                  60                  


Ser Ser Cys Asp Leu Ala Trp Trp Phe Glu Gly Arg Cys Tyr Leu Val 
65                  70                  75                  80  


Ser Cys Pro His Lys Glu Asn Cys Glu Pro Lys Lys Met Gly Pro Ile 
                85                  90                  95      


Arg Ser Tyr Leu Thr Phe Val Leu Arg Pro Val Gln Arg Pro Ala Gln 
            100                 105                 110         


Leu Leu Asp Tyr Gly Asp Met Met Leu Asn Arg Gly Ser Pro Ser Gly 
        115                 120                 125             


Ile Trp Gly Asp Ser Pro Glu Asp Ile Arg Lys Asp Leu Thr Phe Leu 
    130                 135                 140                 


Gly Lys Asp Trp Gly Leu Glu Glu Met Ser Glu Tyr Ser Asp Asp Tyr 
145                 150                 155                 160 


Arg Glu Leu Glu Lys Asp Leu Leu Gln Pro Ser Gly Lys Gln Glu Pro 
                165                 170                 175     


Arg Gly Ser Ala Glu Tyr Thr Asp Trp Gly Leu Leu Pro Gly Ser Glu 
            180                 185                 190         


Gly Ala Phe Asn Ser Ser Val Gly Asp Ser Pro Ala Val Pro Ala Glu 
        195                 200                 205             


Thr Gln Gln Asp Pro Glu Leu His Tyr Leu Asn Glu Ser Ala Ser Thr 
    210                 215                 220                 


Pro Ala Pro Lys Leu Pro Glu Arg Ser Val Leu Leu Pro Leu Pro Thr 
225                 230                 235                 240 


Thr Pro Ser Ser Gly Glu Val Leu Glu Lys Glu Lys Ala Ser Gln Leu 
                245                 250                 255     


Gln Glu Gln Ser Ser Asn Ser Ser Gly Lys Glu Val Leu Met Pro Ser 
            260                 265                 270         


His Ser Leu Pro Pro Ala Ser Leu Glu Leu Ser Ser Val Thr Val Glu 
        275                 280                 285             


Lys Ser Pro Val Leu Thr Val Thr Pro Gly Ser Thr Glu His Ser Ile 
    290                 295                 300                 


Pro Thr Pro Pro Thr Ser Ala Ala Pro Ser Glu Ser Thr Pro Ser Glu 
305                 310                 315                 320 


Leu Pro Ile Ser Pro Thr Thr Ala Pro Arg Thr Val Lys Glu Leu Thr 
                325                 330                 335     


Val Ser Ala Gly Asp Asn Leu Ile Ile Thr Leu Pro Asp Asn Glu Val 
            340                 345                 350         


Glu Leu Lys Ala Phe Val Ala Pro Ala Pro Pro Val Glu Thr Thr Tyr 
        355                 360                 365             


Asn Tyr Glu Trp Asn Leu Ile Ser His Pro Thr Asp Tyr Gln Gly Glu 
    370                 375                 380                 


Ile Lys Gln Gly His Lys Gln Thr Leu Asn Leu Ser Gln Leu Ser Val 
385                 390                 395                 400 


Gly Leu Tyr Val Phe Lys Val Thr Val Ser Ser Glu Asn Ala Phe Gly 
                405                 410                 415     


Glu Gly Phe Val Asn Val Thr Val Lys Pro Ala Arg Arg Val Asn Leu 
            420                 425                 430         


Pro Pro Val Ala Val Val Ser Pro Gln Leu Gln Glu Leu Thr Leu Pro 
        435                 440                 445             


Leu Thr Ser Ala Leu Ile Asp Gly Ser Gln Ser Thr Asp Asp Thr Glu 
    450                 455                 460                 


Ile Val Ser Tyr His Trp Glu Glu Ile Asn Gly Pro Phe Ile Glu Glu 
465                 470                 475                 480 


Lys Thr Ser Val Asp Ser Pro Val Leu Arg Leu Ser Asn Leu Asp Pro 
                485                 490                 495     


Gly Asn Tyr Ser Phe Arg Leu Thr Val Thr Asp Ser Asp Gly Ala Thr 
            500                 505                 510         


Asn Ser Thr Thr Ala Ala Leu Ile Val Asn Asn Ala Val Asp Tyr Pro 
        515                 520                 525             


Pro Val Ala Asn Ala Gly Pro Asn His Thr Ile Thr Leu Pro Gln Asn 
    530                 535                 540                 


Ser Ile Thr Leu Asn Gly Asn Gln Ser Ser Asp Asp His Gln Ile Val 
545                 550                 555                 560 


Leu Tyr Glu Trp Ser Leu Gly Pro Gly Ser Glu Gly Lys His Val Val 
                565                 570                 575     


Met Gln Gly Val Gln Thr Pro Tyr Leu His Leu Ser Ala Met Gln Glu 
            580                 585                 590         


Gly Asp Tyr Thr Phe Gln Leu Lys Val Thr Asp Ser Ser Arg Gln Gln 
        595                 600                 605             


Ser Thr Ala Val Val Thr Val Ile Val Gln Pro Glu Asn Asn Arg Pro 
    610                 615                 620                 


Pro Val Ala Val Ala Gly Pro Asp Lys Glu Leu Ile Phe Pro Val Glu 
625                 630                 635                 640 


Ser Ala Thr Leu Asp Gly Ser Ser Ser Ser Asp Asp His Gly Ile Val 
                645                 650                 655     


Phe Tyr His Trp Glu His Val Arg Gly Pro Ser Ala Val Glu Met Glu 
            660                 665                 670         


Asn Ile Asp Lys Ala Ile Ala Thr Val Thr Gly Leu Gln Val Gly Thr 
        675                 680                 685             


Tyr His Phe Arg Leu Thr Val Lys Asp Gln Gln Gly Leu Ser Ser Thr 
    690                 695                 700                 


Ser Thr Leu Thr Val Ala Val Lys Lys Glu Asn Asn Ser Pro Pro Arg 
705                 710                 715                 720 


Ala Arg Ala Gly Gly Arg His Val Leu Val Leu Pro Asn Asn Ser Ile 
                725                 730                 735     


Thr Leu Asp Gly Ser Arg Ser Thr Asp Asp Gln Arg Ile Val Ser Tyr 
            740                 745                 750         


Leu Trp Ile Arg Asp Gly Gln Ser Pro Ala Ala Gly Asp Val Ile Asp 
        755                 760                 765             


Gly Ser Asp His Ser Val Ala Leu Gln Leu Thr Asn Leu Val Glu Gly 
    770                 775                 780                 


Val Tyr Thr Phe His Leu Arg Val Thr Asp Ser Gln Gly Ala Ser Asp 
785                 790                 795                 800 


Thr Asp Thr Ala Thr Val Glu Val Gln Pro Asp Pro Arg Lys Ser Gly 
                805                 810                 815     


Leu Val Glu Leu Thr Leu Gln Val Gly Val Gly Gln Leu Thr Glu Gln 
            820                 825                 830         


Arg Lys Asp Thr Leu Val Arg Gln Leu Ala Val Leu Leu Asn Val Leu 
        835                 840                 845             


Asp Ser Asp Ile Lys Val Gln Lys Ile Arg Ala His Ser Asp Leu Ser 
    850                 855                 860                 


Thr Val Ile Val Phe Tyr Val Gln Ser Arg Pro Pro Phe Lys Val Leu 
865                 870                 875                 880 


Lys Ala Ala Glu Val Ala Arg Asn Leu His Met Arg Leu Ser Lys Glu 
                885                 890                 895     


Lys Ala Asp Phe Leu Leu Phe Lys Val Leu Arg Val Asp Thr Ala Gly 
            900                 905                 910         


Cys Leu Leu Lys Cys Ser Gly His Gly His Cys Asp Pro Leu Thr Lys 
        915                 920                 925             


Arg Cys Ile Cys Ser His Leu Trp Met Glu Asn Leu Ile Gln Arg Tyr 
    930                 935                 940                 


Ile Trp Asp Gly Glu Ser Asn Cys Glu Trp Ser Ile Phe Tyr Val Thr 
945                 950                 955                 960 


Val Leu Ala Phe Thr Leu Ile Val Leu Thr Gly Gly Phe Thr Trp Leu 
                965                 970                 975     


Cys Ile Cys Cys Cys Lys Arg Gln Lys Arg Thr Lys Ile Arg Lys Lys 
            980                 985                 990         


Thr Lys Tyr Thr Ile Leu Asp Asn  Met Asp Glu Gln Glu  Arg Met Glu 
        995                 1000                 1005             


Leu Arg  Pro Lys Tyr Gly Ile  Lys His Arg Ser Thr  Glu His Asn 
    1010                 1015                 1020             


Ser Ser  Leu Met Val Ser Glu  Ser Glu Phe Asp Ser  Asp Gln Asp 
    1025                 1030                 1035             


Thr Ile  Phe Ser Arg Glu Lys  Met Glu Arg Gly Asn  Pro Lys Val 
    1040                 1045                 1050             


Ser Met  Asn Gly Ser Ile Arg  Asn Gly Ala Ser Phe  Ser Tyr Cys 
    1055                 1060                 1065             


Ser Lys  Asp Arg 
    1070         


<210>  2229
<211>  1027
<212>  PRT
<213>  Homo sapiens

<400>  2229

Met Arg Val Ser His Thr Phe Pro Val Val Asp Cys Thr Ala Ala Cys 
1               5                   10                  15      


Cys Asp Leu Ser Ser Cys Asp Leu Ala Trp Trp Phe Glu Gly Arg Cys 
            20                  25                  30          


Tyr Leu Val Ser Cys Pro His Lys Glu Asn Cys Glu Pro Lys Lys Met 
        35                  40                  45              


Gly Pro Ile Arg Ser Tyr Leu Thr Phe Val Leu Arg Pro Val Gln Arg 
    50                  55                  60                  


Pro Ala Gln Leu Leu Asp Tyr Gly Asp Met Met Leu Asn Arg Gly Ser 
65                  70                  75                  80  


Pro Ser Gly Ile Trp Gly Asp Ser Pro Glu Asp Ile Arg Lys Asp Leu 
                85                  90                  95      


Thr Phe Leu Gly Lys Asp Trp Gly Leu Glu Glu Met Ser Glu Tyr Ser 
            100                 105                 110         


Asp Asp Tyr Arg Glu Leu Glu Lys Asp Leu Leu Gln Pro Ser Gly Lys 
        115                 120                 125             


Gln Glu Pro Arg Gly Ser Ala Glu Tyr Thr Asp Trp Gly Leu Leu Pro 
    130                 135                 140                 


Gly Ser Glu Gly Ala Phe Asn Ser Ser Val Gly Asp Ser Pro Ala Val 
145                 150                 155                 160 


Pro Ala Glu Thr Gln Gln Asp Pro Glu Leu His Tyr Leu Asn Glu Ser 
                165                 170                 175     


Ala Ser Thr Pro Ala Pro Lys Leu Pro Glu Arg Ser Val Leu Leu Pro 
            180                 185                 190         


Leu Pro Thr Thr Pro Ser Ser Gly Glu Val Leu Glu Lys Glu Lys Ala 
        195                 200                 205             


Ser Gln Leu Gln Glu Gln Ser Ser Asn Ser Ser Gly Lys Glu Val Leu 
    210                 215                 220                 


Met Pro Ser His Ser Leu Pro Pro Ala Ser Leu Glu Leu Ser Ser Val 
225                 230                 235                 240 


Thr Val Glu Lys Ser Pro Val Leu Thr Val Thr Pro Gly Ser Thr Glu 
                245                 250                 255     


His Ser Ile Pro Thr Pro Pro Thr Ser Ala Ala Pro Ser Glu Ser Thr 
            260                 265                 270         


Pro Ser Glu Leu Pro Ile Ser Pro Thr Thr Ala Pro Arg Thr Val Lys 
        275                 280                 285             


Glu Leu Thr Val Ser Ala Gly Asp Asn Leu Ile Ile Thr Leu Pro Asp 
    290                 295                 300                 


Asn Glu Val Glu Leu Lys Ala Phe Val Ala Pro Ala Pro Pro Val Glu 
305                 310                 315                 320 


Thr Thr Tyr Asn Tyr Glu Trp Asn Leu Ile Ser His Pro Thr Asp Tyr 
                325                 330                 335     


Gln Gly Glu Ile Lys Gln Gly His Lys Gln Thr Leu Asn Leu Ser Gln 
            340                 345                 350         


Leu Ser Val Gly Leu Tyr Val Phe Lys Val Thr Val Ser Ser Glu Asn 
        355                 360                 365             


Ala Phe Gly Glu Gly Phe Val Asn Val Thr Val Lys Pro Ala Arg Arg 
    370                 375                 380                 


Val Asn Leu Pro Pro Val Ala Val Val Ser Pro Gln Leu Gln Glu Leu 
385                 390                 395                 400 


Thr Leu Pro Leu Thr Ser Ala Leu Ile Asp Gly Ser Gln Ser Thr Asp 
                405                 410                 415     


Asp Thr Glu Ile Val Ser Tyr His Trp Glu Glu Ile Asn Gly Pro Phe 
            420                 425                 430         


Ile Glu Glu Lys Thr Ser Val Asp Ser Pro Val Leu Arg Leu Ser Asn 
        435                 440                 445             


Leu Asp Pro Gly Asn Tyr Ser Phe Arg Leu Thr Val Thr Asp Ser Asp 
    450                 455                 460                 


Gly Ala Thr Asn Ser Thr Thr Ala Ala Leu Ile Val Asn Asn Ala Val 
465                 470                 475                 480 


Asp Tyr Pro Pro Val Ala Asn Ala Gly Pro Asn His Thr Ile Thr Leu 
                485                 490                 495     


Pro Gln Asn Ser Ile Thr Leu Asn Gly Asn Gln Ser Ser Asp Asp His 
            500                 505                 510         


Gln Ile Val Leu Tyr Glu Trp Ser Leu Gly Pro Gly Ser Glu Gly Lys 
        515                 520                 525             


His Val Val Met Gln Gly Val Gln Thr Pro Tyr Leu His Leu Ser Ala 
    530                 535                 540                 


Met Gln Glu Gly Asp Tyr Thr Phe Gln Leu Lys Val Thr Asp Ser Ser 
545                 550                 555                 560 


Arg Gln Gln Ser Thr Ala Val Val Thr Val Ile Val Gln Pro Glu Asn 
                565                 570                 575     


Asn Arg Pro Pro Val Ala Val Ala Gly Pro Asp Lys Glu Leu Ile Phe 
            580                 585                 590         


Pro Val Glu Ser Ala Thr Leu Asp Gly Ser Ser Ser Ser Asp Asp His 
        595                 600                 605             


Gly Ile Val Phe Tyr His Trp Glu His Val Arg Gly Pro Ser Ala Val 
    610                 615                 620                 


Glu Met Glu Asn Ile Asp Lys Ala Ile Ala Thr Val Thr Gly Leu Gln 
625                 630                 635                 640 


Val Gly Thr Tyr His Phe Arg Leu Thr Val Lys Asp Gln Gln Gly Leu 
                645                 650                 655     


Ser Ser Thr Ser Thr Leu Thr Val Ala Val Lys Lys Glu Asn Asn Ser 
            660                 665                 670         


Pro Pro Arg Ala Arg Ala Gly Gly Arg His Val Leu Val Leu Pro Asn 
        675                 680                 685             


Asn Ser Ile Thr Leu Asp Gly Ser Arg Ser Thr Asp Asp Gln Arg Ile 
    690                 695                 700                 


Val Ser Tyr Leu Trp Ile Arg Asp Gly Gln Ser Pro Ala Ala Gly Asp 
705                 710                 715                 720 


Val Ile Asp Gly Ser Asp His Ser Val Ala Leu Gln Leu Thr Asn Leu 
                725                 730                 735     


Val Glu Gly Val Tyr Thr Phe His Leu Arg Val Thr Asp Ser Gln Gly 
            740                 745                 750         


Ala Ser Asp Thr Asp Thr Ala Thr Val Glu Val Gln Pro Asp Pro Arg 
        755                 760                 765             


Lys Ser Gly Leu Val Glu Leu Thr Leu Gln Val Gly Val Gly Gln Leu 
    770                 775                 780                 


Thr Glu Gln Arg Lys Asp Thr Leu Val Arg Gln Leu Ala Val Leu Leu 
785                 790                 795                 800 


Asn Val Leu Asp Ser Asp Ile Lys Val Gln Lys Ile Arg Ala His Ser 
                805                 810                 815     


Asp Leu Ser Thr Val Ile Val Phe Tyr Val Gln Ser Arg Pro Pro Phe 
            820                 825                 830         


Lys Val Leu Lys Ala Ala Glu Val Ala Arg Asn Leu His Met Arg Leu 
        835                 840                 845             


Ser Lys Glu Lys Ala Asp Phe Leu Leu Phe Lys Val Leu Arg Val Asp 
    850                 855                 860                 


Thr Ala Gly Cys Leu Leu Lys Cys Ser Gly His Gly His Cys Asp Pro 
865                 870                 875                 880 


Leu Thr Lys Arg Cys Ile Cys Ser His Leu Trp Met Glu Asn Leu Ile 
                885                 890                 895     


Gln Arg Tyr Ile Trp Asp Gly Glu Ser Asn Cys Glu Trp Ser Ile Phe 
            900                 905                 910         


Tyr Val Thr Val Leu Ala Phe Thr Leu Ile Val Leu Thr Gly Gly Phe 
        915                 920                 925             


Thr Trp Leu Cys Ile Cys Cys Cys Lys Arg Gln Lys Arg Thr Lys Ile 
    930                 935                 940                 


Arg Lys Lys Thr Lys Tyr Thr Ile Leu Asp Asn Met Asp Glu Gln Glu 
945                 950                 955                 960 


Arg Met Glu Leu Arg Pro Lys Tyr Gly Ile Lys His Arg Ser Thr Glu 
                965                 970                 975     


His Asn Ser Ser Leu Met Val Ser Glu Ser Glu Phe Asp Ser Asp Gln 
            980                 985                 990         


Asp Thr Ile Phe Ser Arg Glu Lys  Met Glu Arg Gly Asn  Pro Lys Val 
        995                 1000                 1005             


Ser Met  Asn Gly Ser Ile Arg  Asn Gly Ala Ser Phe  Ser Tyr Cys 
    1010                 1015                 1020             


Ser Lys  Asp Arg 
    1025         


<210>  2230
<211>  1011
<212>  PRT
<213>  Homo sapiens

<400>  2230

Met Ala Pro Pro Thr Gly Val Leu Ser Ser Leu Leu Leu Leu Val Thr 
1               5                   10                  15      


Ile Ala Gly Cys Ala Arg Lys Gln Cys Ser Glu Gly Arg Thr Tyr Ser 
            20                  25                  30          


Asn Ala Val Ile Ser Pro Asn Leu Glu Thr Thr Arg Ile Met Arg Val 
        35                  40                  45              


Ser His Thr Phe Pro Val Val Asp Cys Thr Ala Ala Cys Cys Asp Leu 
    50                  55                  60                  


Ser Ser Cys Asp Leu Ala Trp Trp Phe Glu Gly Arg Cys Tyr Leu Val 
65                  70                  75                  80  


Ser Cys Pro His Lys Glu Asn Cys Glu Pro Lys Lys Met Gly Pro Ile 
                85                  90                  95      


Arg Ser Tyr Leu Thr Phe Val Leu Arg Pro Val Gln Arg Pro Ala Gln 
            100                 105                 110         


Leu Leu Asp Tyr Gly Asp Met Met Leu Asn Arg Gly Ser Pro Ser Gly 
        115                 120                 125             


Ile Trp Gly Asp Ser Pro Glu Asp Ile Arg Lys Asp Leu Thr Phe Leu 
    130                 135                 140                 


Gly Lys Asp Trp Gly Leu Glu Glu Met Ser Glu Tyr Ser Asp Asp Tyr 
145                 150                 155                 160 


Arg Glu Leu Glu Lys Asp Leu Leu Gln Pro Ser Gly Lys Gln Glu Pro 
                165                 170                 175     


Arg Gly Ser Ala Glu Tyr Thr Asp Trp Gly Leu Leu Pro Gly Ser Glu 
            180                 185                 190         


Gly Ala Phe Asn Ser Ser Val Gly Asp Ser Pro Ala Val Pro Ala Glu 
        195                 200                 205             


Thr Gln Gln Asp Pro Glu Leu His Tyr Leu Asn Glu Ser Ala Ser Thr 
    210                 215                 220                 


Pro Ala Pro Lys Leu Pro Glu Arg Ser Val Leu Leu Pro Leu Pro Thr 
225                 230                 235                 240 


Thr Pro Ser Ser Gly Glu Val Leu Glu Lys Glu Lys Ala Ser Gln Leu 
                245                 250                 255     


Gln Glu Gln Ser Ser Asn Ser Ser Gly Lys Glu Val Leu Met Pro Ser 
            260                 265                 270         


His Ser Leu Pro Pro Ala Ser Leu Glu Leu Ser Ser Val Thr Val Glu 
        275                 280                 285             


Lys Ser Pro Val Leu Thr Val Thr Pro Gly Ser Thr Glu His Ser Ile 
    290                 295                 300                 


Pro Thr Pro Pro Thr Ser Ala Ala Pro Ser Glu Ser Thr Pro Ser Glu 
305                 310                 315                 320 


Leu Pro Ile Ser Pro Thr Thr Ala Pro Arg Thr Val Lys Glu Leu Thr 
                325                 330                 335     


Val Ser Ala Gly Asp Asn Leu Ile Ile Thr Leu Pro Asp Asn Glu Val 
            340                 345                 350         


Glu Leu Lys Ala Phe Val Ala Pro Ala Pro Pro Val Glu Thr Thr Tyr 
        355                 360                 365             


Asn Tyr Glu Trp Asn Leu Ile Ser His Pro Thr Asp Tyr Gln Gly Glu 
    370                 375                 380                 


Ile Lys Gln Gly His Lys Gln Thr Leu Asn Leu Ser Gln Leu Ser Val 
385                 390                 395                 400 


Gly Leu Tyr Val Phe Lys Val Thr Val Ser Ser Glu Asn Ala Phe Gly 
                405                 410                 415     


Glu Gly Phe Val Asn Val Thr Val Lys Pro Ala Arg Arg Val Asn Leu 
            420                 425                 430         


Pro Pro Val Ala Val Val Ser Pro Gln Leu Gln Glu Leu Thr Leu Pro 
        435                 440                 445             


Leu Thr Ser Ala Leu Ile Asp Gly Ser Gln Ser Thr Asp Asp Thr Glu 
    450                 455                 460                 


Ile Val Ser Tyr His Trp Glu Glu Ile Asn Gly Pro Phe Ile Glu Glu 
465                 470                 475                 480 


Lys Thr Ser Val Asp Ser Pro Val Leu Arg Leu Ser Asn Leu Asp Pro 
                485                 490                 495     


Gly Asn Tyr Ser Phe Arg Leu Thr Val Thr Asp Ser Asp Gly Ala Thr 
            500                 505                 510         


Asn Ser Thr Thr Ala Ala Leu Ile Val Asn Asn Ala Val Asp Tyr Pro 
        515                 520                 525             


Pro Val Ala Asn Ala Gly Pro Asn His Thr Ile Thr Leu Pro Gln Asn 
    530                 535                 540                 


Ser Ile Thr Leu Asn Gly Asn Gln Ser Ser Asp Asp His Gln Ile Val 
545                 550                 555                 560 


Leu Tyr Glu Trp Ser Leu Gly Pro Gly Ser Glu Gly Lys His Val Val 
                565                 570                 575     


Met Gln Gly Val Gln Thr Pro Tyr Leu His Leu Ser Ala Met Gln Glu 
            580                 585                 590         


Gly Asp Tyr Thr Phe Gln Leu Lys Val Thr Asp Ser Ser Arg Gln Gln 
        595                 600                 605             


Ser Thr Ala Val Val Thr Val Ile Val Gln Pro Glu Asn Asn Arg Pro 
    610                 615                 620                 


Pro Val Ala Val Ala Gly Pro Asp Lys Glu Leu Ile Phe Pro Val Glu 
625                 630                 635                 640 


Ser Ala Thr Leu Asp Gly Ser Ser Ser Ser Asp Asp His Gly Ile Val 
                645                 650                 655     


Phe Tyr His Trp Glu His Val Arg Gly Pro Ser Ala Val Glu Met Glu 
            660                 665                 670         


Asn Ile Asp Lys Ala Ile Ala Thr Val Thr Gly Leu Gln Val Gly Thr 
        675                 680                 685             


Tyr His Phe Arg Leu Thr Val Lys Asp Gln Gln Gly Leu Ser Ser Thr 
    690                 695                 700                 


Ser Thr Leu Thr Val Ala Val Lys Lys Glu Asn Asn Ser Pro Pro Arg 
705                 710                 715                 720 


Ala Arg Ala Gly Gly Arg His Val Leu Val Leu Pro Asn Asn Ser Ile 
                725                 730                 735     


Thr Leu Asp Gly Ser Arg Ser Thr Asp Asp Gln Arg Ile Val Ser Tyr 
            740                 745                 750         


Leu Trp Ile Arg Asp Gly Gln Ser Pro Ala Ala Gly Asp Val Ile Asp 
        755                 760                 765             


Gly Ser Asp His Ser Val Ala Leu Gln Leu Thr Asn Leu Val Glu Gly 
    770                 775                 780                 


Val Tyr Thr Phe His Leu Arg Val Thr Asp Ser Gln Gly Ala Ser Asp 
785                 790                 795                 800 


Thr Asp Thr Ala Thr Val Glu Val Gln Pro Asp Pro Arg Lys Ser Gly 
                805                 810                 815     


Leu Val Glu Leu Thr Leu Gln Val Gly Val Gly Gln Leu Thr Glu Gln 
            820                 825                 830         


Arg Lys Asp Thr Leu Val Arg Gln Leu Ala Val Leu Leu Asn Val Leu 
        835                 840                 845             


Asp Ser Asp Ile Lys Val Gln Lys Ile Arg Ala His Ser Asp Leu Ser 
    850                 855                 860                 


Thr Val Ile Val Phe Tyr Val Gln Ser Arg Pro Pro Phe Lys Val Leu 
865                 870                 875                 880 


Lys Ala Ala Glu Val Ala Arg Asn Leu His Met Arg Leu Ser Lys Glu 
                885                 890                 895     


Lys Ala Asp Phe Leu Leu Phe Lys Val Leu Arg Val Asp Thr Ala Gly 
            900                 905                 910         


Cys Leu Leu Lys Cys Ser Gly His Gly His Cys Asp Pro Leu Thr Lys 
        915                 920                 925             


Arg Cys Ile Cys Ser His Leu Trp Met Glu Asn Leu Ile Gln Arg Tyr 
    930                 935                 940                 


Ile Trp Asp Gly Glu Ser Asn Cys Gly Ile Lys His Arg Ser Thr Glu 
945                 950                 955                 960 


His Asn Ser Ser Leu Met Val Ser Glu Ser Glu Phe Asp Ser Asp Gln 
                965                 970                 975     


Asp Thr Ile Phe Ser Arg Glu Lys Met Glu Arg Gly Asn Pro Lys Val 
            980                 985                 990         


Ser Met Asn Gly Ser Ile Arg Asn  Gly Ala Ser Phe Ser  Tyr Cys Ser 
        995                 1000                 1005             


Lys Asp  Arg 
    1010     


<210>  2231
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  2231

Met Ala Ala Pro Arg Asp Asn Val Thr Leu Leu Phe Lys Leu Tyr Cys 
1               5                   10                  15      


Leu Ala Val Met Thr Leu Met Ala Ala Val Tyr Thr Ile Ala Leu Arg 
            20                  25                  30          


Tyr Thr Arg Thr Ser Asp Lys Glu Leu Tyr Phe Ser Thr Thr Ala Val 
        35                  40                  45              


Cys Ile Thr Glu Val Ile Lys Leu Leu Leu Ser Val Gly Ile Leu Ala 
    50                  55                  60                  


Lys Glu Thr Gly Ser Leu Gly Arg Phe Lys Ala Ser Leu Arg Glu Asn 
65                  70                  75                  80  


Val Leu Gly Ser Pro Lys Glu Leu Leu Lys Leu Ser Val Pro Ser Leu 
                85                  90                  95      


Val Tyr Ala Val Gln Asn Asn Met Ala Phe Leu Ala Leu Ser Asn Leu 
            100                 105                 110         


Asp Ala Ala Val Tyr Gln Val Thr Tyr Gln Leu Lys Ile Pro Cys Thr 
        115                 120                 125             


Ala Leu Cys Thr Val Leu Met Leu Asn Arg Thr Leu Ser Lys Leu Gln 
    130                 135                 140                 


Trp Val Ser Val Phe Met Leu Cys Ala Gly Val Thr Leu Val Gln Trp 
145                 150                 155                 160 


Lys Pro Ala Gln Ala Thr Lys Val Val Val Glu Gln Asn Pro Leu Leu 
                165                 170                 175     


Gly Phe Gly Ala Ile Ala Ile Ala Val Leu Cys Ser Gly Phe Ala Val 
            180                 185                 190         


Leu Ala Ser Val Gly Gly Leu Tyr Thr Ser Val Val Val Lys Tyr Thr 
        195                 200                 205             


Asp Asn Ile Met Lys Gly Phe Ser Ala Ala Ala Ala Ile Val Leu Ser 
    210                 215                 220                 


Thr Ile Ala Ser Val Met Leu Phe Gly Leu Gln Ile Thr Leu Thr Phe 
225                 230                 235                 240 


Ala Leu Gly Thr Leu Leu Val Cys Val Ser Ile Tyr Leu Tyr Gly Leu 
                245                 250                 255     


Pro Arg Gln Asp Thr Thr Ser Ile Gln Gln Gly Glu Thr Ala Ser Lys 
            260                 265                 270         


Glu Arg Val Ile Gly Val 
        275             


<210>  2232
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  2232

Met Gly Gln Cys Gly Ile Thr Ser Ser Lys Thr Val Leu Val Phe Leu 
1               5                   10                  15      


Asn Leu Ile Phe Trp Phe Val Ile Ile Leu Leu Leu Val Phe Val Thr 
            20                  25                  30          


Glu Val Val Val Val Val Leu Gly Tyr Val Tyr Arg Ala Lys Val Glu 
        35                  40                  45              


Asn Glu Val Asp Arg Ser Ile Gln Lys Val Tyr Lys Thr Tyr Asn Gly 
    50                  55                  60                  


Thr Asn Pro Asp Ala Ala Ser Arg Ala Ile Asp Tyr Val Gln Arg Gln 
65                  70                  75                  80  


Leu His Cys Cys Gly Ile His Asn Tyr Ser Asp Trp Glu Asn Thr Asp 
                85                  90                  95      


Trp Phe Lys Glu Thr Lys Asn Gln Ser Val Pro Leu Ser Cys Cys Arg 
            100                 105                 110         


Glu Thr Ala Ser Asn Cys Asn Gly Ser Leu Ala His Pro Ser Asp Leu 
        115                 120                 125             


Tyr Ala Glu Gly Cys Glu Ala Leu Val Val Lys Lys Leu Gln Glu Ile 
    130                 135                 140                 


Met Met His Val Ile Trp Ala Ala Leu Ala Phe Ala Ala Ile Gln Leu 
145                 150                 155                 160 


Leu Gly Met Leu Cys Ala Cys Ile Val Leu Cys Arg Arg Ser Arg Asp 
                165                 170                 175     


Pro Ala Tyr Glu Leu Leu Ile Thr Gly Gly Thr Tyr Ala 
            180                 185                 


<210>  2233
<211>  1503
<212>  PRT
<213>  Homo sapiens

<400>  2233

Met Ala Ala Pro Ala Glu Pro Cys Ala Gly Gln Gly Val Trp Asn Gln 
1               5                   10                  15      


Thr Glu Pro Glu Pro Ala Ala Thr Ser Leu Leu Ser Leu Cys Phe Leu 
            20                  25                  30          


Arg Thr Ala Gly Val Trp Val Pro Pro Met Tyr Leu Trp Val Leu Gly 
        35                  40                  45              


Pro Ile Tyr Leu Leu Phe Ile His His His Gly Arg Gly Tyr Leu Arg 
    50                  55                  60                  


Met Ser Pro Leu Phe Lys Ala Lys Met Val Leu Gly Phe Ala Leu Ile 
65                  70                  75                  80  


Val Leu Cys Thr Ser Ser Val Ala Val Ala Leu Trp Lys Ile Gln Gln 
                85                  90                  95      


Gly Thr Pro Glu Ala Pro Glu Phe Leu Ile His Pro Thr Val Trp Leu 
            100                 105                 110         


Thr Thr Met Ser Phe Ala Val Phe Leu Ile His Thr Glu Arg Lys Lys 
        115                 120                 125             


Gly Val Gln Ser Ser Gly Val Leu Phe Gly Tyr Trp Leu Leu Cys Phe 
    130                 135                 140                 


Val Leu Pro Ala Thr Asn Ala Ala Gln Gln Ala Ser Gly Ala Gly Phe 
145                 150                 155                 160 


Gln Ser Asp Pro Val Arg His Leu Ser Thr Tyr Leu Cys Leu Ser Leu 
                165                 170                 175     


Val Val Ala Gln Phe Val Leu Ser Cys Leu Ala Asp Gln Pro Pro Phe 
            180                 185                 190         


Phe Pro Glu Asp Pro Gln Gln Ser Asn Pro Cys Pro Glu Thr Gly Ala 
        195                 200                 205             


Ala Phe Pro Ser Lys Ala Thr Phe Trp Trp Val Ser Gly Leu Val Trp 
    210                 215                 220                 


Arg Gly Tyr Arg Arg Pro Leu Arg Pro Lys Asp Leu Trp Ser Leu Gly 
225                 230                 235                 240 


Arg Glu Asn Ser Ser Glu Glu Leu Val Ser Arg Leu Glu Lys Glu Trp 
                245                 250                 255     


Met Arg Asn Arg Ser Ala Ala Arg Arg His Asn Lys Ala Ile Ala Phe 
            260                 265                 270         


Lys Arg Lys Gly Gly Ser Gly Met Lys Ala Pro Glu Thr Glu Pro Phe 
        275                 280                 285             


Leu Arg Gln Glu Gly Ser Gln Trp Arg Pro Leu Leu Lys Ala Ile Trp 
    290                 295                 300                 


Gln Val Phe His Ser Thr Phe Leu Leu Gly Thr Leu Ser Leu Ile Ile 
305                 310                 315                 320 


Ser Asp Val Phe Arg Phe Thr Val Pro Lys Leu Leu Ser Leu Phe Leu 
                325                 330                 335     


Glu Phe Ile Gly Asp Pro Lys Pro Pro Ala Trp Lys Gly Tyr Leu Leu 
            340                 345                 350         


Ala Val Leu Met Phe Leu Ser Ala Cys Leu Gln Thr Leu Phe Glu Gln 
        355                 360                 365             


Gln Asn Met Tyr Arg Leu Lys Val Leu Gln Met Arg Leu Arg Ser Ala 
    370                 375                 380                 


Ile Thr Gly Leu Val Tyr Arg Lys Val Leu Ala Leu Ser Ser Gly Ser 
385                 390                 395                 400 


Arg Lys Ala Ser Ala Val Gly Asp Val Val Asn Leu Val Ser Val Asp 
                405                 410                 415     


Val Gln Arg Leu Thr Glu Ser Val Leu Tyr Leu Asn Gly Leu Trp Leu 
            420                 425                 430         


Pro Leu Val Trp Ile Val Val Cys Phe Val Tyr Leu Trp Gln Leu Leu 
        435                 440                 445             


Gly Pro Ser Ala Leu Thr Ala Ile Ala Val Phe Leu Ser Leu Leu Pro 
    450                 455                 460                 


Leu Asn Phe Phe Ile Ser Lys Lys Arg Asn His His Gln Glu Glu Gln 
465                 470                 475                 480 


Met Arg Gln Lys Asp Ser Arg Ala Arg Leu Thr Ser Ser Ile Leu Arg 
                485                 490                 495     


Asn Ser Lys Thr Ile Lys Phe His Gly Trp Glu Gly Ala Phe Leu Asp 
            500                 505                 510         


Arg Val Leu Gly Ile Arg Gly Gln Glu Leu Gly Ala Leu Arg Thr Ser 
        515                 520                 525             


Gly Leu Leu Phe Ser Val Ser Leu Val Ser Phe Gln Val Ser Thr Phe 
    530                 535                 540                 


Leu Val Ala Leu Val Val Phe Ala Val His Thr Leu Val Ala Glu Asn 
545                 550                 555                 560 


Ala Met Asn Ala Glu Lys Ala Phe Val Thr Leu Thr Val Leu Asn Ile 
                565                 570                 575     


Leu Asn Lys Ala Gln Ala Phe Leu Pro Phe Ser Ile His Ser Leu Val 
            580                 585                 590         


Gln Ala Arg Val Ser Phe Asp Arg Leu Val Thr Phe Leu Cys Leu Glu 
        595                 600                 605             


Glu Val Asp Pro Gly Val Val Asp Ser Ser Ser Ser Gly Ser Ala Ala 
    610                 615                 620                 


Gly Lys Asp Cys Ile Thr Ile His Ser Ala Thr Phe Ala Trp Ser Gln 
625                 630                 635                 640 


Glu Ser Pro Pro Cys Leu His Arg Ile Asn Leu Thr Val Pro Gln Gly 
                645                 650                 655     


Cys Leu Leu Ala Val Val Gly Pro Val Gly Ala Gly Lys Ser Ser Leu 
            660                 665                 670         


Leu Ser Ala Leu Leu Gly Glu Leu Ser Lys Val Glu Gly Phe Val Ser 
        675                 680                 685             


Ile Glu Gly Ala Val Ala Tyr Val Pro Gln Glu Ala Trp Val Gln Asn 
    690                 695                 700                 


Thr Ser Val Val Glu Asn Val Cys Phe Gly Gln Glu Leu Asp Pro Pro 
705                 710                 715                 720 


Trp Leu Glu Arg Val Leu Glu Ala Cys Ala Leu Gln Pro Asp Val Asp 
                725                 730                 735     


Ser Phe Pro Glu Gly Ile His Thr Ser Ile Gly Glu Gln Gly Met Asn 
            740                 745                 750         


Leu Ser Gly Gly Gln Lys Gln Arg Leu Ser Leu Ala Arg Ala Val Tyr 
        755                 760                 765             


Arg Lys Ala Ala Val Tyr Leu Leu Asp Asp Pro Leu Ala Ala Leu Asp 
    770                 775                 780                 


Ala His Val Gly Gln His Val Phe Asn Gln Val Ile Gly Pro Gly Gly 
785                 790                 795                 800 


Leu Leu Gln Gly Thr Thr Arg Ile Leu Val Thr His Ala Leu His Ile 
                805                 810                 815     


Leu Pro Gln Ala Asp Trp Ile Ile Val Leu Ala Asn Gly Ala Ile Ala 
            820                 825                 830         


Glu Met Gly Ser Tyr Gln Glu Leu Leu Gln Arg Lys Gly Ala Leu Val 
        835                 840                 845             


Cys Leu Leu Asp Gln Ala Arg Gln Pro Gly Asp Arg Gly Glu Gly Glu 
    850                 855                 860                 


Thr Glu Pro Gly Thr Ser Thr Lys Asp Pro Arg Gly Thr Ser Ala Gly 
865                 870                 875                 880 


Arg Arg Pro Glu Leu Arg Arg Glu Arg Ser Ile Lys Ser Val Pro Glu 
                885                 890                 895     


Lys Asp Arg Thr Thr Ser Glu Ala Gln Thr Glu Val Pro Leu Asp Asp 
            900                 905                 910         


Pro Asp Arg Ala Gly Trp Pro Ala Gly Lys Asp Ser Ile Gln Tyr Gly 
        915                 920                 925             


Arg Val Lys Ala Thr Val His Leu Ala Tyr Leu Arg Ala Val Gly Thr 
    930                 935                 940                 


Pro Leu Cys Leu Tyr Ala Leu Phe Leu Phe Leu Cys Gln Gln Val Ala 
945                 950                 955                 960 


Ser Phe Cys Arg Gly Tyr Trp Leu Ser Leu Trp Ala Asp Asp Pro Ala 
                965                 970                 975     


Val Gly Gly Gln Gln Thr Gln Ala Ala Leu Arg Gly Gly Ile Phe Gly 
            980                 985                 990         


Leu Leu Gly Cys Leu Gln Ala Ile  Gly Leu Phe Ala Ser  Met Ala Ala 
        995                 1000                 1005             


Val Leu  Leu Gly Gly Ala Arg  Ala Ser Arg Leu Leu  Phe Gln Arg 
    1010                 1015                 1020             


Leu Leu  Trp Asp Val Val Arg  Ser Pro Ile Ser Phe  Phe Glu Arg 
    1025                 1030                 1035             


Thr Pro  Ile Gly His Leu Leu  Asn Arg Phe Ser Lys  Glu Thr Asp 
    1040                 1045                 1050             


Thr Val  Asp Val Asp Ile Pro  Asp Lys Leu Arg Ser  Leu Leu Met 
    1055                 1060                 1065             


Tyr Ala  Phe Gly Leu Leu Glu  Val Ser Leu Val Val  Ala Val Ala 
    1070                 1075                 1080             


Thr Pro  Leu Ala Thr Val Ala  Ile Leu Pro Leu Phe  Leu Leu Tyr 
    1085                 1090                 1095             


Ala Gly  Phe Gln Ser Leu Tyr  Val Val Ser Ser Cys  Gln Leu Arg 
    1100                 1105                 1110             


Arg Leu  Glu Ser Ala Ser Tyr  Ser Ser Val Cys Ser  His Met Ala 
    1115                 1120                 1125             


Glu Thr  Phe Gln Gly Ser Thr  Val Val Arg Ala Phe  Arg Thr Gln 
    1130                 1135                 1140             


Ala Pro  Phe Val Ala Gln Asn  Asn Ala Arg Val Asp  Glu Ser Gln 
    1145                 1150                 1155             


Arg Ile  Ser Phe Pro Arg Leu  Val Ala Asp Arg Trp  Leu Ala Ala 
    1160                 1165                 1170             


Asn Val  Glu Leu Leu Gly Asn  Gly Leu Val Phe Ala  Ala Ala Thr 
    1175                 1180                 1185             


Cys Ala  Val Leu Ser Lys Ala  His Leu Ser Ala Gly  Leu Val Gly 
    1190                 1195                 1200             


Phe Ser  Val Ser Ala Ala Leu  Gln Val Thr Gln Thr  Leu Gln Trp 
    1205                 1210                 1215             


Val Val  Arg Asn Trp Thr Asp  Leu Glu Asn Ser Ile  Val Ser Val 
    1220                 1225                 1230             


Glu Arg  Met Gln Asp Tyr Ala  Trp Thr Pro Lys Glu  Ala Pro Trp 
    1235                 1240                 1245             


Arg Leu  Pro Thr Cys Ala Ala  Gln Pro Pro Trp Pro  Gln Gly Gly 
    1250                 1255                 1260             


Gln Ile  Glu Phe Arg Asp Phe  Gly Leu Arg Tyr Arg  Pro Glu Leu 
    1265                 1270                 1275             


Pro Leu  Ala Val Gln Gly Val  Ser Phe Lys Ile His  Ala Gly Glu 
    1280                 1285                 1290             


Lys Val  Gly Ile Val Gly Arg  Thr Gly Ala Gly Lys  Ser Ser Leu 
    1295                 1300                 1305             


Ala Ser  Gly Leu Leu Arg Leu  Gln Glu Ala Ala Glu  Gly Gly Ile 
    1310                 1315                 1320             


Trp Ile  Asp Gly Val Pro Ile  Ala His Val Gly Leu  His Thr Leu 
    1325                 1330                 1335             


Arg Ser  Arg Ile Ser Ile Ile  Pro Gln Asp Pro Ile  Leu Phe Pro 
    1340                 1345                 1350             


Gly Ser  Leu Arg Met Asn Leu  Asp Leu Leu Gln Glu  His Ser Asp 
    1355                 1360                 1365             


Glu Ala  Ile Trp Ala Ala Leu  Glu Thr Val Gln Leu  Lys Ala Leu 
    1370                 1375                 1380             


Val Ala  Ser Leu Pro Gly Gln  Leu Gln Tyr Lys Cys  Ala Asp Arg 
    1385                 1390                 1395             


Gly Glu  Asp Leu Ser Val Gly  Gln Lys Gln Leu Leu  Cys Leu Ala 
    1400                 1405                 1410             


Arg Ala  Leu Leu Arg Lys Thr  Gln Ile Leu Ile Leu  Asp Glu Ala 
    1415                 1420                 1425             


Thr Ala  Ala Val Asp Pro Gly  Thr Glu Leu Gln Met  Gln Ala Met 
    1430                 1435                 1440             


Leu Gly  Ser Trp Phe Ala Gln  Cys Thr Val Leu Leu  Ile Ala His 
    1445                 1450                 1455             


Arg Leu  Arg Ser Val Met Asp  Cys Ala Arg Val Leu  Val Met Asp 
    1460                 1465                 1470             


Lys Gly  Gln Val Ala Glu Ser  Gly Ser Pro Ala Gln  Leu Leu Ala 
    1475                 1480                 1485             


Gln Lys  Gly Leu Phe Tyr Arg  Leu Ala Gln Glu Ser  Gly Leu Val 
    1490                 1495                 1500             


<210>  2234
<211>  634
<212>  PRT
<213>  Homo sapiens

<400>  2234

Met Ala Thr Ala Val Ser Arg Pro Cys Ala Gly Arg Ser Arg Asp Ile 
1               5                   10                  15      


Leu Trp Arg Val Leu Gly Trp Arg Ile Val Ala Ser Ile Val Trp Ser 
            20                  25                  30          


Val Leu Phe Leu Pro Ile Cys Thr Thr Val Phe Ile Ile Phe Ser Arg 
        35                  40                  45              


Ile Asp Leu Phe His Pro Ile Gln Trp Leu Ser Asp Ser Phe Ser Asp 
    50                  55                  60                  


Leu Tyr Ser Ser Tyr Val Ile Phe Tyr Phe Leu Leu Leu Ser Val Val 
65                  70                  75                  80  


Ile Ile Ile Ile Ser Ile Phe Asn Val Glu Phe Tyr Ala Val Ile Thr 
                85                  90                  95      


Gln Gly Gln Tyr Ser Phe Leu Val Val Pro Cys Thr Gly Thr Asn Ser 
            100                 105                 110         


Phe Gly Ser Pro Ala Ala Gln Thr Cys Leu Asn Glu Tyr His Leu Phe 
        115                 120                 125             


Phe Leu Leu Thr Gly Ala Phe Met Gly Tyr Ser Tyr Ser Leu Leu Tyr 
    130                 135                 140                 


Phe Val Asn Asn Met Asn Tyr Leu Pro Phe Pro Ile Ile Gln Gln Tyr 
145                 150                 155                 160 


Lys Phe Leu Arg Phe Arg Arg Ser Leu Leu Leu Leu Val Lys His Ser 
                165                 170                 175     


Cys Val Glu Ser Leu Phe Leu Val Arg Asn Phe Cys Ile Leu Tyr Tyr 
            180                 185                 190         


Phe Leu Gly Tyr Ile Pro Lys Ala Trp Ile Ser Thr Ala Met Asn Leu 
        195                 200                 205             


His Ile Asp Glu Gln Val His Arg Pro Leu Asp Thr Val Ser Gly Leu 
    210                 215                 220                 


Leu Asn Leu Ser Leu Leu Tyr His Val Trp Leu Cys Gly Val Phe Leu 
225                 230                 235                 240 


Leu Thr Thr Trp Tyr Val Ser Trp Ile Leu Phe Lys Ile Tyr Ala Thr 
                245                 250                 255     


Glu Ala His Val Phe Pro Val Gln Pro Pro Phe Ala Glu Gly Ser Asp 
            260                 265                 270         


Glu Cys Leu Pro Lys Val Leu Asn Ser Asn Pro Pro Pro Ile Ile Lys 
        275                 280                 285             


Tyr Leu Ala Leu Gln Asp Leu Met Leu Leu Ser Gln Tyr Ser Pro Ser 
    290                 295                 300                 


Arg Arg Gln Glu Val Phe Ser Leu Ser Gln Pro Gly Gly His Pro His 
305                 310                 315                 320 


Asn Trp Thr Ala Ile Ser Arg Glu Cys Leu Asn Leu Leu Asn Gly Met 
                325                 330                 335     


Thr Gln Lys Leu Ile Leu Tyr Gln Glu Ala Ala Ala Thr Asn Gly Arg 
            340                 345                 350         


Val Ser Ser Ser Tyr Pro Val Glu Pro Lys Lys Leu Asn Ser Pro Glu 
        355                 360                 365             


Glu Thr Ala Phe Gln Thr Pro Lys Ser Ser Gln Met Pro Arg Pro Ser 
    370                 375                 380                 


Val Pro Pro Leu Val Lys Thr Ser Leu Phe Ser Ser Lys Leu Ser Thr 
385                 390                 395                 400 


Pro Asp Val Val Ser Pro Phe Gly Thr Pro Phe Gly Ser Ser Val Met 
                405                 410                 415     


Asn Arg Met Ala Gly Ile Phe Asp Val Asn Thr Cys Tyr Gly Ser Pro 
            420                 425                 430         


Gln Ser Pro Gln Leu Ile Arg Arg Gly Pro Arg Leu Trp Thr Ser Ala 
        435                 440                 445             


Ser Asp Gln Gln Met Thr Glu Phe Ser Asn Pro Ser Pro Ser Thr Ser 
    450                 455                 460                 


Ile Ser Ala Glu Gly Lys Thr Met Arg Gln Pro Ser Val Ile Tyr Ser 
465                 470                 475                 480 


Trp Ile Gln Asn Lys Arg Glu Gln Ile Lys Asn Phe Leu Ser Lys Arg 
                485                 490                 495     


Val Leu Ile Met Tyr Phe Phe Ser Lys His Pro Glu Ala Ser Ile Gln 
            500                 505                 510         


Ala Val Phe Ser Asp Ala Gln Met His Ile Trp Ala Leu Glu Gly Leu 
        515                 520                 525             


Ser His Leu Val Ala Ala Ser Phe Thr Glu Asp Arg Phe Gly Val Val 
    530                 535                 540                 


Gln Thr Thr Leu Pro Ala Ile Leu Asn Thr Leu Leu Thr Leu Gln Glu 
545                 550                 555                 560 


Ala Val Asp Lys Tyr Phe Lys Leu Pro His Ala Ser Ser Lys Pro Pro 
                565                 570                 575     


Arg Ile Ser Gly Ser Leu Val Asp Thr Ser Tyr Lys Thr Leu Arg Phe 
            580                 585                 590         


Ala Phe Arg Ala Ser Leu Lys Thr Ala Ile Tyr Arg Ile Thr Thr Thr 
        595                 600                 605             


Phe Gly Glu His Leu Asn Ala Val Gln Ala Ser Ala Glu His Gln Lys 
    610                 615                 620                 


Arg Leu Gln Gln Phe Leu Glu Phe Lys Glu 
625                 630                 


<210>  2235
<211>  436
<212>  PRT
<213>  Homo sapiens

<400>  2235

Met Ala Ala Leu Ser Lys Ser Ile Pro His Asn Cys Tyr Glu Ile Gly 
1               5                   10                  15      


His Thr Trp His Pro Ser Cys Arg Val Ser Phe Leu Gln Ile Thr Gly 
            20                  25                  30          


Gly Ala Leu Glu Glu Ser Leu Lys Ile Tyr Ala Pro Leu Tyr Leu Ile 
        35                  40                  45              


Ala Ala Ile Leu Arg Lys Arg Lys Leu Asp Tyr Tyr Leu His Lys Leu 
    50                  55                  60                  


Leu Pro Glu Ile Leu Gln Ser Ala Ser Phe Leu Thr Ala Asn Gly Ala 
65                  70                  75                  80  


Leu Tyr Met Ala Phe Phe Cys Ile Leu Arg Lys Ile Leu Gly Lys Phe 
                85                  90                  95      


Tyr Ser Trp Thr Pro Gly Phe Gly Ala Ala Leu Pro Ala Ser Tyr Val 
            100                 105                 110         


Ala Ile Leu Ile Glu Arg Lys Ser Arg Arg Gly Leu Leu Thr Ile Tyr 
        115                 120                 125             


Met Ala Asn Leu Val Leu Leu Phe Cys Ile Thr Ala Ala Met Tyr Met 
    130                 135                 140                 


Phe Phe Phe Arg Cys Lys Asp Gly Leu Lys Gly Phe Thr Phe Ser Ala 
145                 150                 155                 160 


Leu Arg Phe Ile Val Gly Lys Glu Glu Ile Pro Thr His Ser Phe Ser 
                165                 170                 175     


Pro Glu Ala Ala Tyr Ala Lys Val Glu Gln Lys Arg Glu Gln His Glu 
            180                 185                 190         


Glu Lys Pro Gly Arg Met Asn Met Ile Gly Leu Val Arg Lys Phe Val 
        195                 200                 205             


Asp Ser Ile Cys Lys His Gly Pro Arg His Arg Cys Cys Lys His Tyr 
    210                 215                 220                 


Glu Asp Asn Cys Ile Ser Tyr Cys Ile Lys Gly Phe Ile Arg Met Phe 
225                 230                 235                 240 


Ser Val Gly Tyr Leu Ile Gln Cys Cys Leu Arg Ile Pro Ser Ala Phe 
                245                 250                 255     


Arg His Leu Phe Thr Gln Pro Ser Arg Leu Leu Ser Leu Phe Tyr Asn 
            260                 265                 270         


Lys Glu Asn Phe Gln Leu Gly Ala Phe Leu Gly Ser Phe Val Ser Ile 
        275                 280                 285             


Tyr Lys Gly Thr Ser Cys Phe Leu Arg Trp Ile Arg Asn Leu Asp Asp 
    290                 295                 300                 


Glu Leu His Ala Ile Ile Ala Gly Phe Leu Ala Gly Ile Ser Met Met 
305                 310                 315                 320 


Phe Tyr Lys Ser Thr Thr Ile Ser Met Tyr Leu Ala Ser Lys Leu Val 
                325                 330                 335     


Glu Thr Met Tyr Phe Lys Gly Ile Glu Ala Gly Lys Val Pro Tyr Phe 
            340                 345                 350         


Pro His Ala Asp Thr Ile Ile Tyr Ser Ile Ser Thr Ala Ile Cys Phe 
        355                 360                 365             


Gln Ala Ala Val Met Glu Val Gln Thr Leu Arg Pro Ser Tyr Trp Lys 
    370                 375                 380                 


Phe Leu Leu Arg Leu Thr Lys Gly Lys Phe Ala Val Met Asn Arg Lys 
385                 390                 395                 400 


Val Leu Asp Val Phe Gly Thr Gly Ala Ser Lys His Phe Gln Asp Phe 
                405                 410                 415     


Ile Pro Arg Leu Asp Pro Arg Tyr Thr Thr Val Thr Pro Glu Leu Pro 
            420                 425                 430         


Thr Glu Phe Ser 
        435     


<210>  2236
<211>  599
<212>  PRT
<213>  Homo sapiens

<400>  2236

Met Leu Val Leu Gly Leu Leu Val Ala Gly Ala Ala Asp Gly Cys Glu 
1               5                   10                  15      


Leu Val Pro Arg His Leu Arg Gly Arg Arg Ala Thr Gly Ser Ala Ala 
            20                  25                  30          


Thr Ala Ala Ser Ser Pro Ala Ala Ala Ala Gly Asp Ser Pro Ala Leu 
        35                  40                  45              


Met Thr Asp Pro Cys Met Ser Leu Ser Pro Pro Cys Phe Thr Glu Glu 
    50                  55                  60                  


Asp Arg Phe Ser Leu Glu Ala Leu Gln Thr Ile His Lys Gln Met Asp 
65                  70                  75                  80  


Asp Asp Lys Asp Gly Gly Ile Glu Val Glu Glu Ser Asp Glu Phe Ile 
                85                  90                  95      


Arg Glu Asp Met Lys Tyr Lys Asp Ala Thr Asn Lys His Ser His Leu 
            100                 105                 110         


His Arg Glu Asp Lys His Ile Thr Ile Glu Asp Leu Trp Lys Arg Trp 
        115                 120                 125             


Lys Thr Ser Glu Val His Asn Trp Thr Leu Glu Asp Thr Leu Gln Trp 
    130                 135                 140                 


Leu Ile Glu Phe Val Glu Leu Pro Gln Tyr Glu Lys Asn Phe Arg Asp 
145                 150                 155                 160 


Asn Asn Val Lys Gly Thr Thr Leu Pro Arg Ile Ala Val His Glu Pro 
                165                 170                 175     


Ser Phe Met Ile Ser Gln Leu Lys Ile Ser Asp Arg Ser His Arg Gln 
            180                 185                 190         


Lys Leu Gln Leu Lys Ala Leu Asp Val Val Leu Phe Gly Pro Leu Thr 
        195                 200                 205             


Arg Pro Pro His Asn Trp Met Lys Asp Phe Ile Leu Thr Val Ser Ile 
    210                 215                 220                 


Val Ile Gly Val Gly Gly Cys Trp Phe Ala Tyr Thr Gln Asn Lys Thr 
225                 230                 235                 240 


Ser Lys Glu His Val Ala Lys Met Met Lys Asp Leu Glu Ser Leu Gln 
                245                 250                 255     


Thr Ala Glu Gln Ser Leu Met Asp Leu Gln Glu Arg Leu Glu Lys Ala 
            260                 265                 270         


Gln Glu Glu Asn Arg Asn Val Ala Val Glu Lys Gln Asn Leu Glu Arg 
        275                 280                 285             


Lys Met Met Asp Glu Ile Asn Tyr Ala Lys Glu Glu Ala Cys Arg Leu 
    290                 295                 300                 


Arg Glu Leu Arg Glu Gly Ala Glu Cys Glu Leu Ser Arg Arg Gln Tyr 
305                 310                 315                 320 


Ala Glu Gln Glu Leu Glu Gln Val Arg Met Ala Leu Lys Lys Ala Glu 
                325                 330                 335     


Lys Glu Phe Glu Leu Arg Ser Ser Trp Ser Val Pro Asp Ala Leu Gln 
            340                 345                 350         


Lys Trp Leu Gln Leu Thr His Glu Val Glu Val Gln Tyr Tyr Asn Ile 
        355                 360                 365             


Lys Arg Gln Asn Ala Glu Met Gln Leu Ala Ile Ala Lys Asp Glu Ala 
    370                 375                 380                 


Glu Lys Ile Lys Lys Lys Arg Ser Thr Val Phe Gly Thr Leu His Val 
385                 390                 395                 400 


Ala His Ser Ser Ser Leu Asp Glu Val Asp His Lys Ile Leu Glu Ala 
                405                 410                 415     


Lys Lys Ala Leu Ser Glu Leu Thr Thr Cys Leu Arg Glu Arg Leu Phe 
            420                 425                 430         


Arg Trp Gln Gln Ile Glu Lys Ile Cys Gly Phe Gln Ile Ala His Asn 
        435                 440                 445             


Ser Gly Leu Pro Ser Leu Thr Ser Ser Leu Tyr Ser Asp His Ser Trp 
    450                 455                 460                 


Val Val Met Pro Arg Val Ser Ile Pro Pro Tyr Pro Ile Ala Gly Gly 
465                 470                 475                 480 


Val Asp Asp Leu Asp Glu Asp Thr Pro Pro Ile Val Ser Gln Phe Pro 
                485                 490                 495     


Gly Thr Met Ala Lys Pro Pro Gly Ser Leu Ala Arg Ser Ser Ser Leu 
            500                 505                 510         


Cys Arg Ser Arg Arg Ser Ile Val Pro Ser Ser Pro Gln Pro Gln Arg 
        515                 520                 525             


Ala Gln Leu Ala Pro His Ala Pro His Pro Ser His Pro Arg His Pro 
    530                 535                 540                 


His His Pro Gln His Thr Pro His Ser Leu Pro Ser Pro Asp Pro Asp 
545                 550                 555                 560 


Ile Leu Ser Val Ser Ser Cys Pro Ala Leu Tyr Arg Asn Glu Glu Glu 
                565                 570                 575     


Glu Glu Ala Ile Tyr Phe Ser Ala Glu Lys Gln Cys Ile His Leu Gly 
            580                 585                 590         


Leu Gly Ala Cys Lys Ser Glu 
        595                 


<210>  2237
<211>  754
<212>  PRT
<213>  Homo sapiens

<400>  2237

Met Leu Val Leu Gly Leu Leu Val Ala Gly Ala Ala Asp Gly Cys Glu 
1               5                   10                  15      


Leu Val Pro Arg His Leu Arg Gly Arg Arg Ala Thr Gly Ser Ala Ala 
            20                  25                  30          


Thr Ala Ala Ser Ser Pro Ala Ala Ala Ala Gly Asp Ser Pro Ala Leu 
        35                  40                  45              


Met Thr Asp Pro Cys Met Ser Leu Ser Pro Pro Cys Phe Thr Glu Glu 
    50                  55                  60                  


Asp Arg Phe Ser Leu Glu Ala Leu Gln Thr Ile His Lys Gln Met Asp 
65                  70                  75                  80  


Asp Asp Lys Asp Gly Gly Ile Glu Val Glu Glu Ser Asp Glu Phe Ile 
                85                  90                  95      


Arg Glu Asp Met Lys Tyr Lys Asp Ala Thr Asn Lys His Ser His Leu 
            100                 105                 110         


His Arg Glu Asp Lys His Ile Thr Ile Glu Asp Leu Trp Lys Arg Trp 
        115                 120                 125             


Lys Thr Ser Glu Val His Asn Trp Thr Leu Glu Asp Thr Leu Gln Trp 
    130                 135                 140                 


Leu Ile Glu Phe Val Glu Leu Pro Gln Tyr Glu Lys Asn Phe Arg Asp 
145                 150                 155                 160 


Asn Asn Val Lys Gly Thr Thr Leu Pro Arg Ile Ala Val His Glu Pro 
                165                 170                 175     


Ser Phe Met Ile Ser Gln Leu Lys Ile Ser Asp Arg Ser His Arg Gln 
            180                 185                 190         


Lys Leu Gln Leu Lys Ala Leu Asp Val Val Leu Phe Gly Pro Leu Thr 
        195                 200                 205             


Arg Pro Pro His Asn Trp Met Lys Asp Phe Ile Leu Thr Val Ser Ile 
    210                 215                 220                 


Val Ile Gly Val Gly Gly Cys Trp Phe Ala Tyr Thr Gln Asn Lys Thr 
225                 230                 235                 240 


Ser Lys Glu His Val Ala Lys Met Met Lys Asp Leu Glu Ser Leu Gln 
                245                 250                 255     


Thr Ala Glu Gln Ser Leu Met Asp Leu Gln Glu Arg Leu Glu Lys Ala 
            260                 265                 270         


Gln Glu Glu Asn Arg Asn Val Ala Val Glu Lys Gln Asn Leu Glu Arg 
        275                 280                 285             


Lys Met Met Asp Glu Ile Asn Tyr Ala Lys Glu Glu Ala Cys Arg Leu 
    290                 295                 300                 


Arg Glu Leu Arg Glu Gly Ala Glu Cys Glu Leu Ser Arg Arg Gln Tyr 
305                 310                 315                 320 


Ala Glu Gln Glu Leu Glu Gln Val Arg Met Ala Leu Lys Lys Ala Glu 
                325                 330                 335     


Lys Glu Phe Glu Leu Arg Ser Ser Trp Ser Val Pro Asp Ala Leu Gln 
            340                 345                 350         


Lys Trp Leu Gln Leu Thr His Glu Val Glu Val Gln Tyr Tyr Asn Ile 
        355                 360                 365             


Lys Arg Gln Asn Ala Glu Met Gln Leu Ala Ile Ala Lys Asp Glu Val 
    370                 375                 380                 


Ala Ala Ser Tyr Leu Ile Gln Ala Glu Lys Ile Lys Lys Lys Arg Ser 
385                 390                 395                 400 


Thr Val Phe Gly Thr Leu His Val Ala His Ser Ser Ser Leu Asp Glu 
                405                 410                 415     


Val Asp His Lys Ile Leu Glu Ala Lys Lys Ala Leu Ser Glu Leu Thr 
            420                 425                 430         


Thr Cys Leu Arg Glu Arg Leu Phe Arg Trp Gln Gln Ile Glu Lys Ile 
        435                 440                 445             


Cys Gly Phe Gln Ile Ala His Asn Ser Gly Leu Pro Ser Leu Thr Ser 
    450                 455                 460                 


Ser Leu Tyr Ser Asp His Ser Trp Val Val Met Pro Arg Val Ser Ile 
465                 470                 475                 480 


Pro Pro Tyr Pro Ile Ala Gly Gly Val Asp Asp Leu Asp Glu Asp Thr 
                485                 490                 495     


Pro Pro Ile Val Ser Gln Phe Pro Gly Thr Met Ala Lys Pro Pro Gly 
            500                 505                 510         


Ser Leu Ala Arg Ser Ser Ser Leu Cys Arg Ser Arg Arg Ser Ile Val 
        515                 520                 525             


Pro Ser Ser Pro Gln Pro Gln Arg Ala Gln Leu Ala Pro His Ala Pro 
    530                 535                 540                 


His Pro Ser His Pro Arg His Pro His His Pro Gln His Thr Pro His 
545                 550                 555                 560 


Ser Leu Pro Ser Pro Asp Pro Asp Ile Leu Ser Val Ser Ser Cys Pro 
                565                 570                 575     


Ala Leu Tyr Arg Asn Glu Glu Glu Glu Glu Ala Ile Tyr Phe Ser Ala 
            580                 585                 590         


Glu Lys Gln Trp Glu Val Pro Asp Thr Ala Ser Glu Cys Asp Ser Leu 
        595                 600                 605             


Asn Ser Ser Ile Gly Arg Lys Gln Ser Pro Pro Leu Ser Leu Glu Ile 
    610                 615                 620                 


Tyr Gln Thr Leu Ser Pro Arg Lys Ile Ser Arg Asp Glu Val Ser Leu 
625                 630                 635                 640 


Glu Asp Ser Ser Arg Gly Asp Ser Pro Val Thr Val Asp Val Ser Trp 
                645                 650                 655     


Gly Ser Pro Asp Cys Val Gly Leu Thr Glu Thr Lys Ser Met Ile Phe 
            660                 665                 670         


Ser Pro Ala Ser Lys Val Tyr Asn Gly Ile Leu Glu Lys Ser Cys Ser 
        675                 680                 685             


Met Asn Gln Leu Ser Ser Gly Ile Pro Val Pro Lys Pro Arg His Thr 
    690                 695                 700                 


Ser Cys Ser Ser Ala Gly Asn Asp Ser Lys Pro Val Gln Glu Ala Pro 
705                 710                 715                 720 


Ser Val Ala Arg Ile Ser Ser Ile Pro His Asp Leu Cys His Asn Gly 
                725                 730                 735     


Glu Lys Ser Lys Lys Pro Ser Lys Ile Lys Ser Leu Phe Lys Lys Lys 
            740                 745                 750         


Ser Lys 
        


<210>  2238
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  2238

Met Gly Ser Pro Gly Met Val Leu Gly Leu Leu Val Gln Ile Trp Ala 
1               5                   10                  15      


Leu Gln Glu Ala Ser Ser Leu Ser Val Gln Gln Gly Pro Asn Leu Leu 
            20                  25                  30          


Gln Val Arg Gln Gly Ser Gln Ala Thr Leu Val Cys Gln Val Asp Gln 
        35                  40                  45              


Ala Thr Ala Trp Glu Arg Leu Arg Val Lys Trp Thr Lys Asp Gly Ala 
    50                  55                  60                  


Ile Leu Cys Gln Pro Tyr Ile Thr Asn Gly Ser Leu Ser Leu Gly Val 
65                  70                  75                  80  


Cys Gly Pro Gln Gly Arg Leu Ser Trp Gln Ala Pro Ser His Leu Thr 
                85                  90                  95      


Leu Gln Leu Asp Pro Val Ser Leu Asn His Ser Gly Ala Tyr Val Cys 
            100                 105                 110         


Trp Ala Ala Val Glu Ile Pro Glu Leu Glu Glu Ala Glu Gly Asn Ile 
        115                 120                 125             


Thr Arg Leu Phe Val Asp Pro Asp Asp Pro Thr Gln Asn Arg Asn Arg 
    130                 135                 140                 


Ile Ala Ser Phe Pro Gly Phe Leu Phe Val Leu Leu Gly Val Gly Ser 
145                 150                 155                 160 


Met Gly Val Ala Ala Ile Val Trp Gly Ala Trp Phe Trp Gly Arg Arg 
                165                 170                 175     


Ser Cys Gln Gln Arg Asp Ser Gly Asn Ala Phe Tyr Ser Asn Val Leu 
            180                 185                 190         


Tyr Arg Pro Arg Gly Ala Pro Lys Lys Ser Glu Asp Cys Ser Gly Glu 
        195                 200                 205             


Gly Lys Asp Gln Arg Gly Gln Ser Ile Tyr Ser Thr Ser Phe Pro Gln 
    210                 215                 220                 


Pro Ala Pro Arg Gln Pro His Leu Ala Ser Arg Pro Cys Pro Ser Pro 
225                 230                 235                 240 


Arg Pro Cys Pro Ser Pro Arg Pro Gly His Pro Val Ser Met Val Arg 
                245                 250                 255     


Val Ser Pro Arg Pro Ser Pro Thr Gln Gln Pro Arg Pro Lys Gly Phe 
            260                 265                 270         


Pro Lys Val Gly Glu Glu 
        275             


<210>  2239
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  2239

Met Thr Ser Leu Ile Asn Ser Pro Ile Asn Arg Arg Pro Leu Gln Asn 
1               5                   10                  15      


Val Glu Gly Asn Asn Arg Cys Gln Arg Lys Ala Lys Asn Tyr Gly Asn 
            20                  25                  30          


Lys Tyr Phe Ile His Cys Leu Asp Leu Glu Lys Ile Thr Leu Ser Pro 
        35                  40                  45              


Arg Arg Lys His Asp Ile Glu Gly Gly Asp Lys Leu Asn Val Lys Phe 
    50                  55                  60                  


Ser Gln Leu Arg Ser Arg Arg Gln Arg Lys Ala Glu Pro Gly Ala Cys 
65                  70                  75                  80  


Ala Leu Gly Arg Val Gly Ser Glu Cys Ile Pro Glu Pro Gly Ala Arg 
                85                  90                  95      


Arg Thr Ala Gln Ala Ala Gly Leu Arg Ser Val Ser Gly Ala Ala Asn 
            100                 105                 110         


Thr Lys Val Arg Glu Leu Lys His Phe Arg Phe Leu Gly Leu Leu Arg 
        115                 120                 125             


Ser Cys Arg Ser Glu Met Glu Val Asp Ala Pro Gly Val Asp Gly Arg 
    130                 135                 140                 


Asp Gly Leu Arg Glu Arg Arg Gly Phe Ser Glu Gly Gly Arg Gln Asn 
145                 150                 155                 160 


Phe Asp Val Arg Pro Gln Ser Gly Ala Asn Gly Leu Pro Lys His Ser 
                165                 170                 175     


Tyr Trp Leu Asp Leu Trp Leu Phe Ile Leu Phe Asp Val Val Val Phe 
            180                 185                 190         


Leu Phe Val Tyr Phe Leu Pro 
        195                 


<210>  2240
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  2240

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Asp Pro Phe 
            20                  25                  30          


Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala Val Leu Pro Val 
        35                  40                  45              


Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu Cys Leu Gln Tyr 
    50                  55                  60                  


Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn Leu His Arg Thr 
65                  70                  75                  80  


Phe Glu Ser Phe Gly Val Leu Gly Pro Gln Val Lys Glu Pro Lys Lys 
                85                  90                  95      


Thr Gly Gln Phe Leu Glu Glu Leu Arg Asn Pro Phe 
            100                 105             


<210>  2241
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  2241

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Glu Ser Phe Gly Val Leu Gly Pro Gln Val Lys 
        195                 200                 205             


Glu Pro Lys Lys Thr Gly Gln Phe Leu Glu Glu Leu Arg Asn Pro Phe 
    210                 215                 220                 


<210>  2242
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  2242

Met Ala Phe Arg Gln Ala Leu Gln Leu Ala Ala Cys Gly Leu Ala Gly 
1               5                   10                  15      


Gly Ser Ala Ala Val Leu Phe Ser Ala Val Ala Val Gly Lys Pro Arg 
            20                  25                  30          


Ala Gly Gly Asp Ala Glu Pro Arg Pro Ala Glu Pro Pro Ala Trp Ala 
        35                  40                  45              


Gly Gly Ala Arg Pro Gly Pro Gly Val Trp Asp Pro Asn Trp Asp Arg 
    50                  55                  60                  


Arg Glu Pro Leu Ser Leu Ile Asn Val Arg Lys Arg Asn Val Glu Ser 
65                  70                  75                  80  


Gly Glu Glu Glu Leu Ala Ser Lys Leu Asp His Tyr Lys Ala Lys Ala 
                85                  90                  95      


Thr Arg His Ile Phe Leu Ile Arg His Ser Gln Tyr His Val Asp Gly 
            100                 105                 110         


Ser Leu Glu Lys Asp Arg Thr Leu Thr Pro Leu Gly Arg Glu Gln Ala 
        115                 120                 125             


Glu Leu Thr Gly Leu Arg Leu Ala Ser Leu Gly Leu Lys Phe Asn Lys 
    130                 135                 140                 


Ile Val His Ser Ser Met Thr Arg Ala Ile Glu Thr Thr Asp Ile Ile 
145                 150                 155                 160 


Ser Arg His Leu Pro Gly Val Cys Lys Val Ser Thr Asp Leu Leu Arg 
                165                 170                 175     


Glu Gly Ala Pro Ile Glu Pro Asp Pro Pro Val Ser His Trp Lys Pro 
            180                 185                 190         


Glu Ala Val Gln Tyr Tyr Glu Asp Gly Ala Arg Ile Glu Ala Ala Phe 
        195                 200                 205             


Arg Asn Tyr Ile His Arg Ala Asp Ala Arg Gln Glu Glu Asp Ser Tyr 
    210                 215                 220                 


Glu Ile Phe Ile Cys His Ala Asn Val Ile Arg Tyr Ile Val Cys Arg 
225                 230                 235                 240 


Ala Leu Gln Phe Pro Pro Glu Gly Trp Leu Arg Leu Ser Leu Asn Asn 
                245                 250                 255     


Gly Ser Ile Thr His Leu Val Ile Arg Pro Asn Gly Arg Val Ala Leu 
            260                 265                 270         


Arg Thr Leu Gly Asp Thr Gly Phe Met Pro Pro Asp Lys Ile Thr Arg 
        275                 280                 285             


Ser 
    


<210>  2243
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  2243

Met Ala Phe Arg Gln Ala Leu Gln Leu Ala Ala Cys Gly Leu Ala Gly 
1               5                   10                  15      


Gly Ser Ala Ala Val Leu Phe Ser Ala Val Ala Val Gly Lys Pro Arg 
            20                  25                  30          


Ala Gly Gly Asp Ala Glu Pro Arg Pro Ala Glu Pro Pro Ala Trp Ala 
        35                  40                  45              


Gly Gly Ala Arg Pro Gly Pro Gly Val Trp Asp Pro Asn Trp Asp Arg 
    50                  55                  60                  


Arg Glu Pro Leu Ser Leu Ile Asn Val Arg Lys Arg Asn Val Glu Ser 
65                  70                  75                  80  


Gly Glu Glu Glu Leu Ala Ser Lys Leu Asp His Tyr Lys Ala Lys Ala 
                85                  90                  95      


Thr Arg His Ile Phe Leu Ile Arg His Ser Gln Tyr His Val Asp Gly 
            100                 105                 110         


Ser Leu Glu Lys Asp Arg Thr Leu Thr Pro Leu Gly Arg Glu Gln Ala 
        115                 120                 125             


Glu Leu Thr Gly Leu Arg Leu Ala Ser Leu Gly Leu Lys Phe Asn Lys 
    130                 135                 140                 


Ile Val His Ser Ser Met Thr Arg Ala Ile Glu Thr Thr Asp Ile Ile 
145                 150                 155                 160 


Ser Arg His Leu Pro Gly Val Cys Lys Val Ser Thr Asp Leu Leu Arg 
                165                 170                 175     


Glu Gly Ala Pro Ile Glu Pro Asp Pro Pro Val Ser His Trp Lys Pro 
            180                 185                 190         


Glu Ala Val Tyr Tyr Glu Asp Gly Ala Arg Ile Glu Ala Ala Phe Arg 
        195                 200                 205             


Asn Tyr Ile His Arg Ala Asp Ala Arg Gln Glu Glu Asp Ser Tyr Glu 
    210                 215                 220                 


Ile Phe Ile Cys His Ala Asn Val Ile Arg Tyr Ile Val Cys Arg Ala 
225                 230                 235                 240 


Leu Gln Phe Pro Pro Glu Gly Trp Leu Arg Leu Ser Leu Asn Asn Gly 
                245                 250                 255     


Ser Ile Thr His Leu Val Ile Arg Pro Asn Gly Arg Val Ala Leu Arg 
            260                 265                 270         


Thr Leu Gly Asp Thr Gly Phe Met Pro Pro Asp Lys Ile Thr Arg Ser 
        275                 280                 285             


<210>  2244
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  2244

Met Val Phe Ala Phe Trp Lys Val Phe Leu Ile Leu Ser Cys Leu Ala 
1               5                   10                  15      


Gly Gln Val Ser Val Val Gln Val Thr Ile Pro Asp Gly Phe Val Asn 
            20                  25                  30          


Val Thr Val Gly Ser Asn Val Thr Leu Ile Cys Ile Tyr Thr Thr Thr 
        35                  40                  45              


Val Ala Ser Arg Glu Gln Leu Ser Ile Gln Trp Ser Phe Phe His Lys 
    50                  55                  60                  


Lys Glu Met Glu Pro Ile Ser His Ser Ser Cys Leu Ser Thr Glu Gly 
65                  70                  75                  80  


Met Glu Glu Lys Ala Val Ser Gln Cys Leu Lys Met Thr His Ala Arg 
                85                  90                  95      


Asp Ala Arg Gly Arg Cys Ser Trp Thr Ser Glu Ile Tyr Phe Ser Gln 
            100                 105                 110         


Gly Gly Gln Ala Val Ala Ile Gly Gln Phe Lys Asp Arg Ile Thr Gly 
        115                 120                 125             


Ser Asn Asp Pro Gly Asn Ala Ser Ile Thr Ile Ser His Met Gln Pro 
    130                 135                 140                 


Ala Asp Ser Gly Ile Tyr Ile Cys Asp Val Asn Asn Pro Pro Asp Phe 
145                 150                 155                 160 


Leu Gly Gln Asn Gln Gly Ile Leu Asn Val Ser Val Leu Val Lys Pro 
                165                 170                 175     


Ser Lys Pro Leu Cys Ser Val Gln Gly Arg Pro Glu Thr Gly His Thr 
            180                 185                 190         


Ile Ser Leu Ser Cys Leu Ser Ala Leu Gly Thr Pro Ser Pro Val Tyr 
        195                 200                 205             


Tyr Trp His Lys Leu Glu Gly Arg Asp Ile Val Pro Val Lys Glu Asn 
    210                 215                 220                 


Phe Asn Pro Thr Thr Gly Ile Leu Val Ile Gly Asn Leu Thr Asn Phe 
225                 230                 235                 240 


Glu Gln Gly Tyr Tyr Gln Cys Thr Ala Ile Asn Arg Leu Gly Asn Ser 
                245                 250                 255     


Ser Cys Glu Ile Asp Leu Thr Ser Ser His Pro Glu Val Gly Ile Ile 
            260                 265                 270         


Val Gly Ala Leu Ile Gly Ser Leu Val Gly Ala Ala Ile Ile Ile Ser 
        275                 280                 285             


Val Val Cys Phe Ala Arg Asn Lys Ala Lys Ala Lys Ala Lys Glu Arg 
    290                 295                 300                 


Asn Ser Lys Thr Ile Ala Glu Leu Glu Pro Met Thr Lys Ile Asn Pro 
305                 310                 315                 320 


Arg Gly Glu Ser Glu Ala Met Pro Arg Glu Asp Ala Thr Gln Leu Glu 
                325                 330                 335     


Val Thr Leu Pro Ser Ser Ile His Glu Thr Gly Pro Asp Thr Ile Gln 
            340                 345                 350         


Glu Pro Asp Tyr Glu Pro Lys Pro Thr Gln Glu Pro Ala Pro Glu Pro 
        355                 360                 365             


Ala Pro Gly Ser Glu Pro Met Ala Val Pro Asp Leu Asp Ile Glu Leu 
    370                 375                 380                 


Glu Leu Glu Pro Glu Thr Gln Ser Glu Leu Glu Pro Glu Pro Glu Pro 
385                 390                 395                 400 


Glu Pro Glu Ser Glu Pro Gly Val Val Val Glu Pro Leu Ser Glu Asp 
                405                 410                 415     


Glu Lys Gly Val Val Lys Ala 
            420             


<210>  2245
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  2245

Met Leu Pro Arg Trp Glu Leu Ala Leu Tyr Leu Leu Ala Ser Leu Gly 
1               5                   10                  15      


Phe His Phe Tyr Ser Phe Tyr Glu Val Tyr Lys Val Ser Arg Glu His 
            20                  25                  30          


Glu Glu Glu Leu Asp Gln Glu Phe Glu Leu Glu Thr Asp Thr Leu Phe 
        35                  40                  45              


Gly Gly Leu Lys Lys Asp Ala Thr Asp Phe Glu Trp Ser Phe Trp Met 
    50                  55                  60                  


Glu Trp Gly Lys Gln Trp Leu Val Trp Leu Leu Leu Gly His Met Val 
65                  70                  75                  80  


Val Ser Gln Met Ala Thr Leu Leu Ala Arg Lys Met Gln Gln Gln Glu 
                85                  90                  95      


His Asp Ser Leu Lys Ala Ser Leu Cys Val Leu Ala Leu Gly Leu Gly 
            100                 105                 110         


Arg Leu Leu Cys Trp Trp Trp Leu Ala Glu Leu Met Ala His Leu Met 
        115                 120                 125             


Tyr Met His Ala Ile Tyr Ser Ser Ile Pro Leu Leu Glu Thr Val Ser 
    130                 135                 140                 


Cys Trp Thr Leu Gly Gly Leu Ala Leu Ala Gln Val Leu Phe Phe Tyr 
145                 150                 155                 160 


Val Lys Tyr Leu Val Leu Phe Gly Val Pro Ala Leu Leu Met Arg Leu 
                165                 170                 175     


Asp Gly Leu Thr Pro Pro Ala Leu Pro Arg Cys Val Ser Thr Met Phe 
            180                 185                 190         


Ser Phe Thr Gly Met Trp Arg Tyr Phe Asp Val Gly Leu His Asn Phe 
        195                 200                 205             


Leu Ile Arg Tyr Val Tyr Ile Pro Val Gly Gly Ser Gln His Gly Leu 
    210                 215                 220                 


Leu Gly Thr Leu Phe Ser Thr Ala Met Thr Phe Ala Phe Val Ser Tyr 
225                 230                 235                 240 


Trp His Gly Gly Tyr Asp Tyr Leu Trp Cys Trp Ala Ala Leu Asn Trp 
                245                 250                 255     


Leu Gly Val Thr Val Glu Asn Gly Val Arg Arg Leu Val Glu Thr Pro 
            260                 265                 270         


Cys Ile Gln Asp Ser Leu Ala Arg Tyr Phe Ser Pro Gln Ala Arg Arg 
        275                 280                 285             


Arg Phe His Ala Ala Leu Ala Ser Cys Ser Thr Ser Met Leu Ile Leu 
    290                 295                 300                 


Ser Asn Leu Val Phe Leu Gly Gly Asn Glu Val Gly Lys Thr Tyr Trp 
305                 310                 315                 320 


Asn Arg Ile Phe Ile Gln Gly Trp Pro Trp Val Thr Leu Ser Val Leu 
                325                 330                 335     


Gly Phe Leu Tyr Cys Tyr Ser His Val Gly Ile Ala Trp Ala Gln Thr 
            340                 345                 350         


Tyr Ala Thr Asp 
        355     


<210>  2246
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  2246

Met Leu Pro Arg Trp Glu Leu Ala Leu Tyr Leu Leu Ala Ser Leu Gly 
1               5                   10                  15      


Phe His Phe Tyr Ser Phe Tyr Glu Val Tyr Lys Val Ser Arg Glu His 
            20                  25                  30          


Glu Glu Glu Leu Asp Gln Glu Phe Glu Leu Glu Thr Asp Thr Leu Phe 
        35                  40                  45              


Gly Gly Leu Lys Lys Asp Ala Thr Asp Phe Glu Trp Ser Phe Trp Met 
    50                  55                  60                  


Glu Trp Gly Lys Gln Trp Leu Val Trp Leu Leu Leu Gly His Met Val 
65                  70                  75                  80  


Val Ser Gln Met Ala Thr Leu Leu Ala Arg Lys His Arg Pro Trp Ile 
                85                  90                  95      


Leu Met Leu Tyr Gly Met Trp Ala Cys Trp Cys Val Leu Gly Thr Pro 
            100                 105                 110         


Gly Val Ala Met Val Leu Leu His Thr Thr Ile Ser Phe Cys Val Ala 
        115                 120                 125             


Gln Phe Arg Ser Gln Leu Leu Thr Trp Leu Cys Ser Leu Leu Leu Leu 
    130                 135                 140                 


Ser Thr Leu Arg Leu Gln Gly Val Glu Glu Val Lys Arg Arg Trp Tyr 
145                 150                 155                 160 


Lys Thr Glu Asn Glu Tyr Tyr Leu Leu Gln Phe Thr Leu Thr Val Arg 
                165                 170                 175     


Cys Leu Tyr Tyr Thr Ser Phe Ser Leu Glu Leu Cys Trp Gln Gln Leu 
            180                 185                 190         


Pro Ala Ala Ser Thr Ser Tyr Ser Phe Pro Trp Met Leu Ala Tyr Val 
        195                 200                 205             


Phe Tyr Tyr Pro Val Leu His Asn Gly Pro Ile Leu Ser Phe Ser Glu 
    210                 215                 220                 


Phe Ile Lys Gln Met Gln Gln Gln Glu His Asp Ser Leu Lys Ala Ser 
225                 230                 235                 240 


Leu Cys Val Leu Ala Leu Gly Leu Gly Arg Leu Leu Cys Trp Trp Trp 
                245                 250                 255     


Leu Ala Glu Leu Met Ala His Leu Met Tyr Met His Ala Ile Tyr Ser 
            260                 265                 270         


Ser Ile Pro Leu Leu Glu Thr Val Ser Cys Trp Thr Leu Gly Gly Leu 
        275                 280                 285             


Ala Leu Ala Gln Val Leu Phe Phe Tyr Val Lys Tyr Leu Val Leu Phe 
    290                 295                 300                 


Gly Val Pro Ala Leu Leu Met Arg Leu Asp Gly Leu Thr Pro Pro Ala 
305                 310                 315                 320 


Leu Pro Arg Cys Val Ser Thr Met Phe Ser Phe Thr Gly Met Trp Arg 
                325                 330                 335     


Tyr Phe Asp Val Gly Leu His Asn Phe Leu Ile Arg Tyr Val Tyr Ile 
            340                 345                 350         


Pro Val Gly Gly Ser Gln His Gly Leu Leu Gly Thr Leu Phe Ser Thr 
        355                 360                 365             


Ala Met Thr Phe Ala Phe Val Ser Tyr Trp His Gly Gly Tyr Asp Tyr 
    370                 375                 380                 


Leu Trp Cys Trp Ala Ala Leu Asn Trp Leu Gly Val Thr Val Glu Asn 
385                 390                 395                 400 


Gly Val Arg Arg Leu Val Glu Thr Pro Cys Ile Gln Asp Ser Leu Ala 
                405                 410                 415     


Arg Tyr Phe Ser Pro Gln Ala Arg Arg Arg Phe His Ala Ala Leu Ala 
            420                 425                 430         


Ser Cys Ser Thr Ser Met Leu Ile Leu Ser Asn Leu Val Phe Leu Gly 
        435                 440                 445             


Gly Asn Glu Val Gly Lys Thr Tyr Trp Asn Arg Ile Phe Ile Gln Gly 
    450                 455                 460                 


Trp Pro Trp Val Thr Leu Ser Val Leu Gly Phe Leu Tyr Cys Tyr Ser 
465                 470                 475                 480 


His Val Gly Ile Ala Trp Ala Gln Thr Tyr Ala Thr Asp 
                485                 490             


<210>  2247
<211>  1447
<212>  PRT
<213>  Homo sapiens

<400>  2247

Met Gly Leu Arg Pro Gly Ile Phe Leu Leu Glu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Gly Gln Gly Thr Pro Gln Ile His Thr Ser Pro Arg Lys Ser Thr Leu 
            20                  25                  30          


Glu Gly Gln Leu Trp Pro Glu Thr Leu Lys Asn Ser Pro Phe Pro Cys 
        35                  40                  45              


Asn Pro Asn Lys Leu Gly Val Asn Met Pro Ser Lys Ser Val His Ser 
    50                  55                  60                  


Leu Lys Pro Ser Asp Ile Lys Phe Val Ala Ala Ile Gly Asn Leu Glu 
65                  70                  75                  80  


Ile Pro Pro Asp Pro Gly Thr Gly Asp Leu Glu Lys Gln Asp Trp Thr 
                85                  90                  95      


Glu Arg Pro Gln Gln Val Cys Met Gly Val Met Thr Val Leu Ser Asp 
            100                 105                 110         


Ile Ile Arg Tyr Phe Ser Pro Ser Val Pro Met Pro Val Cys His Thr 
        115                 120                 125             


Gly Lys Arg Val Ile Pro His Asp Gly Ala Glu Asp Leu Trp Ile Gln 
    130                 135                 140                 


Ala Gln Glu Leu Val Arg Asn Met Lys Glu Asn Leu Gln Leu Asp Phe 
145                 150                 155                 160 


Gln Phe Asp Trp Lys Leu Ile Asn Val Phe Phe Ser Asn Ala Ser Gln 
                165                 170                 175     


Cys Tyr Leu Cys Pro Ser Ala Gln Gln Ala Pro Ser Leu Ser Thr Val 
            180                 185                 190         


Leu Leu Ser Gln Asn Gly Leu Ala Ala Gly Gly Val Asp Glu Leu Met 
        195                 200                 205             


Gly Val Leu Asp Tyr Leu Gln Gln Glu Val Pro Arg Ala Phe Val Asn 
    210                 215                 220                 


Leu Val Asp Leu Ser Glu Val Ala Glu Val Ser Arg Gln Tyr His Gly 
225                 230                 235                 240 


Thr Trp Leu Ser Pro Ala Pro Glu Pro Cys Asn Cys Ser Glu Glu Thr 
                245                 250                 255     


Thr Arg Leu Ala Lys Val Val Met Gln Trp Ser Tyr Gln Glu Ala Trp 
            260                 265                 270         


Asn Ser Leu Leu Ala Ser Ser Arg Tyr Ser Glu Gln Glu Ser Phe Thr 
        275                 280                 285             


Val Val Phe Gln Pro Phe Phe Tyr Glu Thr Thr Pro Ser Leu His Ser 
    290                 295                 300                 


Glu Asp Pro Arg Leu Gln Asp Ser Thr Thr Leu Ala Trp His Leu Trp 
305                 310                 315                 320 


Asn Arg Met Met Glu Pro Ala Gly Glu Lys Asp Glu Pro Leu Ser Val 
                325                 330                 335     


Lys His Gly Arg Pro Met Lys Cys Pro Ser Gln Glu Ser Pro Tyr Leu 
            340                 345                 350         


Phe Ser Tyr Arg Asn Ser Asn Tyr Leu Thr Arg Leu Gln Lys Pro Gln 
        355                 360                 365             


Asp Lys Leu Glu Val Arg Glu Gly Ala Glu Ile Arg Cys Pro Asp Lys 
    370                 375                 380                 


Asp Pro Ser Asp Thr Val Pro Thr Ser Val His Arg Leu Lys Pro Ala 
385                 390                 395                 400 


Asp Ile Asn Val Ile Gly Ala Leu Gly Asp Ser Leu Thr Ala Gly Asn 
                405                 410                 415     


Gly Ala Gly Ser Thr Pro Gly Asn Val Leu Asp Val Leu Thr Gln Tyr 
            420                 425                 430         


Arg Gly Leu Ser Trp Ser Val Gly Gly Asp Glu Asn Ile Gly Thr Val 
        435                 440                 445             


Thr Thr Leu Ala Asn Ile Leu Arg Glu Phe Asn Pro Ser Leu Lys Gly 
    450                 455                 460                 


Phe Ser Val Gly Thr Gly Lys Glu Thr Ser Pro Asn Ala Phe Leu Asn 
465                 470                 475                 480 


Gln Ala Val Ala Gly Gly Arg Ala Glu Asp Leu Pro Val Gln Ala Arg 
                485                 490                 495     


Arg Leu Val Asp Leu Met Lys Asn Asp Thr Arg Ile His Phe Gln Glu 
            500                 505                 510         


Asp Trp Lys Ile Ile Thr Leu Phe Ile Gly Gly Asn Asp Leu Cys Asp 
        515                 520                 525             


Phe Cys Asn Asp Leu Val Pro Arg Ala Phe Val Asn Leu Val Thr Val 
    530                 535                 540                 


Leu Glu Ile Val Asn Leu Arg Glu Leu Tyr Gln Glu Lys Lys Val Tyr 
545                 550                 555                 560 


Cys Pro Arg Met Ile Leu Arg Ser Leu Cys Pro Cys Val Leu Lys Phe 
                565                 570                 575     


Asp Asp Asn Ser Thr Glu Leu Ala Thr Leu Ile Glu Phe Asn Lys Lys 
            580                 585                 590         


Phe Gln Glu Lys Thr His Gln Leu Ile Glu Ser Gly Arg Tyr Asp Thr 
        595                 600                 605             


Arg Glu Asp Phe Thr Val Val Val Gln Pro Phe Phe Glu Asn Val Asp 
    610                 615                 620                 


Met Pro Lys Thr Ser Glu Gly Leu Pro Asp Asn Ser Phe Phe Ala Pro 
625                 630                 635                 640 


Asp Cys Phe His Phe Ser Ser Lys Ser His Ser Arg Ala Ala Ser Ala 
                645                 650                 655     


Leu Trp Asn Asn Met Leu Glu Pro Val Gly Gln Lys Thr Thr Arg His 
            660                 665                 670         


Lys Phe Glu Asn Lys Ile Asn Ile Thr Cys Pro Asn Gln Val Gln Pro 
        675                 680                 685             


Phe Leu Arg Thr Tyr Lys Asn Ser Met Gln Gly His Gly Thr Trp Leu 
    690                 695                 700                 


Pro Cys Arg Asp Arg Ala Pro Ser Ala Leu His Pro Thr Ser Val His 
705                 710                 715                 720 


Ala Leu Arg Pro Ala Asp Ile Gln Val Val Ala Ala Leu Gly Asp Ser 
                725                 730                 735     


Leu Thr Ala Gly Asn Gly Ile Gly Ser Lys Pro Asp Asp Leu Pro Asp 
            740                 745                 750         


Val Thr Thr Gln Tyr Arg Gly Leu Ser Tyr Ser Ala Gly Gly Asp Gly 
        755                 760                 765             


Ser Leu Glu Asn Val Thr Thr Leu Pro Asn Ile Leu Arg Glu Phe Asn 
    770                 775                 780                 


Arg Asn Leu Thr Gly Tyr Ala Val Gly Thr Gly Asp Ala Asn Asp Thr 
785                 790                 795                 800 


Asn Ala Phe Leu Asn Gln Ala Val Pro Gly Ala Lys Ala Glu Asp Leu 
                805                 810                 815     


Met Ser Gln Val Gln Thr Leu Met Gln Lys Met Lys Asp Asp His Arg 
            820                 825                 830         


Val Asn Phe His Glu Asp Trp Lys Val Ile Thr Val Leu Ile Gly Gly 
        835                 840                 845             


Ser Asp Leu Cys Asp Tyr Cys Thr Asp Ser Asn Leu Tyr Ser Ala Ala 
    850                 855                 860                 


Asn Phe Val His His Leu Arg Asn Ala Leu Asp Val Leu His Arg Glu 
865                 870                 875                 880 


Val Pro Arg Val Leu Val Asn Leu Val Asp Phe Leu Asn Pro Thr Ile 
                885                 890                 895     


Met Arg Gln Val Phe Leu Gly Asn Pro Asp Lys Cys Pro Val Gln Gln 
            900                 905                 910         


Ala Ser Val Leu Cys Asn Cys Val Leu Thr Leu Arg Glu Asn Ser Gln 
        915                 920                 925             


Glu Leu Ala Arg Leu Glu Ala Phe Ser Arg Ala Tyr Arg Ser Ser Met 
    930                 935                 940                 


Arg Glu Leu Val Gly Ser Gly Arg Tyr Asp Thr Gln Glu Asp Phe Ser 
945                 950                 955                 960 


Val Val Leu Gln Pro Phe Phe Gln Asn Ile Gln Leu Pro Val Leu Ala 
                965                 970                 975     


Asp Gly Leu Pro Asp Thr Ser Phe Phe Ala Pro Asp Cys Ile His Pro 
            980                 985                 990         


Asn Gln Lys Phe His Ser Gln Leu  Ala Arg Ala Leu Trp  Thr Asn Met 
        995                 1000                 1005             


Leu Glu  Pro Leu Gly Ser Lys  Thr Glu Thr Leu Asp  Leu Arg Ala 
    1010                 1015                 1020             


Glu Met  Pro Ile Thr Cys Pro  Thr Gln Asn Glu Pro  Phe Leu Arg 
    1025                 1030                 1035             


Thr Pro  Arg Asn Ser Asn Tyr  Thr Tyr Pro Ile Lys  Pro Ala Ile 
    1040                 1045                 1050             


Glu Asn  Trp Gly Ser Asp Phe  Leu Cys Thr Glu Trp  Lys Ala Ser 
    1055                 1060                 1065             


Asn Ser  Val Pro Thr Ser Val  His Gln Leu Arg Pro  Ala Asp Ile 
    1070                 1075                 1080             


Lys Val  Val Ala Ala Leu Gly  Asp Ser Leu Thr Thr  Ala Val Gly 
    1085                 1090                 1095             


Ala Arg  Pro Asn Asn Ser Ser  Asp Leu Pro Thr Ser  Trp Arg Gly 
    1100                 1105                 1110             


Leu Ser  Trp Ser Ile Gly Gly  Asp Gly Asn Leu Glu  Thr His Thr 
    1115                 1120                 1125             


Thr Leu  Pro Asn Ile Leu Lys  Lys Phe Asn Pro Tyr  Leu Leu Gly 
    1130                 1135                 1140             


Phe Ser  Thr Ser Thr Trp Glu  Gly Thr Ala Gly Leu  Asn Val Ala 
    1145                 1150                 1155             


Ala Glu  Gly Ala Arg Ala Arg  Asp Met Pro Ala Gln  Ala Trp Asp 
    1160                 1165                 1170             


Leu Val  Glu Arg Met Lys Asn  Ser Pro Asp Ile Asn  Leu Glu Lys 
    1175                 1180                 1185             


Asp Trp  Lys Leu Val Thr Leu  Phe Ile Gly Val Asn  Asp Leu Cys 
    1190                 1195                 1200             


His Tyr  Cys Glu Asn Pro Glu  Ala His Leu Ala Thr  Glu Tyr Val 
    1205                 1210                 1215             


Gln His  Ile Gln Gln Ala Leu  Asp Ile Leu Ser Glu  Glu Leu Pro 
    1220                 1225                 1230             


Arg Ala  Phe Val Asn Val Val  Glu Val Met Glu Leu  Ala Ser Leu 
    1235                 1240                 1245             


Tyr Gln  Gly Gln Gly Gly Lys  Cys Ala Met Leu Ala  Ala Gln Asn 
    1250                 1255                 1260             


Asn Cys  Thr Cys Leu Arg His  Ser Gln Ser Ser Leu  Glu Lys Gln 
    1265                 1270                 1275             


Glu Leu  Lys Lys Val Asn Trp  Asn Leu Gln His Gly  Ile Ser Ser 
    1280                 1285                 1290             


Phe Ser  Tyr Trp His Gln Tyr  Thr Gln Arg Glu Asp  Phe Ala Val 
    1295                 1300                 1305             


Val Val  Gln Pro Phe Phe Gln  Asn Thr Leu Thr Pro  Leu Asn Glu 
    1310                 1315                 1320             


Arg Gly  Asp Thr Asp Leu Thr  Phe Phe Ser Glu Asp  Cys Phe His 
    1325                 1330                 1335             


Phe Ser  Asp Arg Gly His Ala  Glu Met Ala Ile Ala  Leu Trp Asn 
    1340                 1345                 1350             


Asn Met  Leu Glu Pro Val Gly  Arg Lys Thr Thr Ser  Asn Asn Phe 
    1355                 1360                 1365             


Thr His  Ser Arg Ala Lys Leu  Lys Cys Pro Ser Pro  Glu Ser Pro 
    1370                 1375                 1380             


Tyr Leu  Tyr Thr Leu Arg Asn  Ser Arg Leu Leu Pro  Asp Gln Ala 
    1385                 1390                 1395             


Glu Glu  Ala Pro Glu Val Leu  Tyr Trp Ala Val Pro  Val Ala Ala 
    1400                 1405                 1410             


Gly Val  Gly Leu Val Val Gly  Ile Ile Gly Thr Val  Val Trp Arg 
    1415                 1420                 1425             


Cys Arg  Arg Gly Gly Arg Arg  Glu Asp Pro Pro Met  Ser Leu Arg 
    1430                 1435                 1440             


Thr Val  Ala Leu 
    1445         


<210>  2248
<211>  494
<212>  PRT
<213>  Homo sapiens

<400>  2248

Met Ser Leu Gly Leu Gly Ser Ala Glu Arg Gly Val Leu Gly Thr Arg 
1               5                   10                  15      


Gly Ala Arg Glu Arg Cys Arg Arg Arg Arg Pro Gly Gln Pro Gly Glu 
            20                  25                  30          


His Glu Glu Glu Leu Asp Gln Glu Phe Glu Leu Glu Thr Asp Thr Leu 
        35                  40                  45              


Phe Gly Gly Leu Lys Lys Asp Ala Thr Asp Phe Glu Trp Ser Phe Trp 
    50                  55                  60                  


Met Glu Trp Gly Lys Gln Trp Leu Val Trp Leu Leu Leu Gly His Met 
65                  70                  75                  80  


Val Val Ser Gln Met Ala Thr Leu Leu Ala Arg Lys His Arg Pro Trp 
                85                  90                  95      


Ile Leu Met Leu Tyr Gly Met Trp Ala Cys Trp Cys Val Leu Gly Thr 
            100                 105                 110         


Pro Gly Val Ala Met Val Leu Leu His Thr Thr Ile Ser Phe Cys Val 
        115                 120                 125             


Ala Gln Phe Arg Ser Gln Leu Leu Thr Trp Leu Cys Ser Leu Leu Leu 
    130                 135                 140                 


Leu Ser Thr Leu Arg Leu Gln Gly Val Glu Glu Val Lys Arg Arg Trp 
145                 150                 155                 160 


Tyr Lys Thr Glu Asn Glu Tyr Tyr Leu Leu Gln Phe Thr Leu Thr Val 
                165                 170                 175     


Arg Cys Leu Tyr Tyr Thr Ser Phe Ser Leu Glu Leu Cys Trp Gln Gln 
            180                 185                 190         


Leu Pro Ala Ala Ser Thr Ser Tyr Ser Phe Pro Trp Met Leu Ala Tyr 
        195                 200                 205             


Val Phe Tyr Tyr Pro Val Leu His Asn Gly Pro Ile Leu Ser Phe Ser 
    210                 215                 220                 


Glu Phe Ile Lys Gln Met Gln Gln Gln Glu His Asp Ser Leu Lys Ala 
225                 230                 235                 240 


Ser Leu Cys Val Leu Ala Leu Gly Leu Gly Arg Leu Leu Cys Trp Trp 
                245                 250                 255     


Trp Leu Ala Glu Leu Met Ala His Leu Met Tyr Met His Ala Ile Tyr 
            260                 265                 270         


Ser Ser Ile Pro Leu Leu Glu Thr Val Ser Cys Trp Thr Leu Gly Gly 
        275                 280                 285             


Leu Ala Leu Ala Gln Val Leu Phe Phe Tyr Val Lys Tyr Leu Val Leu 
    290                 295                 300                 


Phe Gly Val Pro Ala Leu Leu Met Arg Leu Asp Gly Leu Thr Pro Pro 
305                 310                 315                 320 


Ala Leu Pro Arg Cys Val Ser Thr Met Phe Ser Phe Thr Gly Met Trp 
                325                 330                 335     


Arg Tyr Phe Asp Val Gly Leu His Asn Phe Leu Ile Arg Tyr Val Tyr 
            340                 345                 350         


Ile Pro Val Gly Gly Ser Gln His Gly Leu Leu Gly Thr Leu Phe Ser 
        355                 360                 365             


Thr Ala Met Thr Phe Ala Phe Val Ser Tyr Trp His Gly Gly Tyr Asp 
    370                 375                 380                 


Tyr Leu Trp Cys Trp Ala Ala Leu Asn Trp Leu Gly Val Thr Val Glu 
385                 390                 395                 400 


Asn Gly Val Arg Arg Leu Val Glu Thr Pro Cys Ile Gln Asp Ser Leu 
                405                 410                 415     


Ala Arg Tyr Phe Ser Pro Gln Ala Arg Arg Arg Phe His Ala Ala Leu 
            420                 425                 430         


Ala Ser Cys Ser Thr Ser Met Leu Ile Leu Ser Asn Leu Val Phe Leu 
        435                 440                 445             


Gly Gly Asn Glu Val Gly Lys Thr Tyr Trp Asn Arg Ile Phe Ile Gln 
    450                 455                 460                 


Gly Trp Pro Trp Val Thr Leu Ser Val Leu Gly Phe Leu Tyr Cys Tyr 
465                 470                 475                 480 


Ser His Val Gly Ile Ala Trp Ala Gln Thr Tyr Ala Thr Asp 
                485                 490                 


<210>  2249
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  2249

Met Leu Pro Arg Trp Glu Leu Ala Leu Tyr Leu Leu Ala Ser Leu Gly 
1               5                   10                  15      


Phe His Phe Tyr Ser Phe Tyr Glu Val Tyr Lys Val Ser Arg Glu His 
            20                  25                  30          


Glu Glu Glu Leu Asp Gln Glu Phe Glu Leu Glu Thr Asp Thr Leu Phe 
        35                  40                  45              


Gly Gly Leu Lys Lys Asp Ala Thr Asp Phe Glu Trp Ser Phe Trp Met 
    50                  55                  60                  


Glu Trp Gly Lys Gln Trp Leu Val Trp Leu Leu Leu Gly His Met Val 
65                  70                  75                  80  


Val Ser Gln Met Ala Thr Leu Leu Ala Arg Lys Arg Arg Trp Tyr Lys 
                85                  90                  95      


Thr Glu Asn Glu Tyr Tyr Leu Leu Gln Phe Thr Leu Thr Val Arg Cys 
            100                 105                 110         


Leu Tyr Tyr Thr Ser Phe Ser Leu Glu Leu Cys Trp Gln Gln Leu Pro 
        115                 120                 125             


Ala Ala Ser Thr Ser Tyr Ser Phe Pro Trp Met Leu Ala Tyr Val Phe 
    130                 135                 140                 


Tyr Tyr Pro Val Leu His Asn Gly Pro Ile Leu Ser Phe Ser Glu Phe 
145                 150                 155                 160 


Ile Lys Gln Met Gln Gln Gln Glu His Asp Ser Leu Lys Ala Ser Leu 
                165                 170                 175     


Cys Val Leu Ala Leu Gly Leu Gly Arg Leu Leu Cys Trp Trp Trp Leu 
            180                 185                 190         


Ala Glu Leu Met Ala His Leu Met Tyr Met His Ala Ile Tyr Ser Ser 
        195                 200                 205             


Ile Pro Leu Leu Glu Thr Val Ser Cys Trp Thr Leu Gly Gly Leu Ala 
    210                 215                 220                 


Leu Ala Gln Val Leu Phe Phe Tyr Val Lys Tyr Leu Val Leu Phe Gly 
225                 230                 235                 240 


Val Pro Ala Leu Leu Met Arg Leu Asp Gly Leu Thr Pro Pro Ala Leu 
                245                 250                 255     


Pro Arg Cys Val Ser Thr Met Phe Ser Phe Thr Gly Met Trp Arg Tyr 
            260                 265                 270         


Phe Asp Val Gly Leu His Asn Phe Leu Ile Arg Tyr Val Tyr Ile Pro 
        275                 280                 285             


Val Gly Gly Ser Gln His Gly Leu Leu Gly Thr Leu Phe Ser Thr Ala 
    290                 295                 300                 


Met Thr Phe Ala Phe Val Ser Tyr Trp His Gly Gly Tyr Asp Tyr Leu 
305                 310                 315                 320 


Trp Cys Trp Ala Ala Leu Asn Trp Leu Gly Val Thr Val Glu Asn Gly 
                325                 330                 335     


Val Arg Arg Leu Val Glu Thr Pro Cys Ile Gln Asp Ser Leu Ala Arg 
            340                 345                 350         


Tyr Phe Ser Pro Gln Ala Arg Arg Arg Phe His Ala Ala Leu Ala Ser 
        355                 360                 365             


Cys Ser Thr Ser Met Leu Ile Leu Ser Asn Leu Val Phe Leu Gly Gly 
    370                 375                 380                 


Asn Glu Val Gly Lys Thr Tyr Trp Asn Arg Ile Phe Ile Gln Gly Trp 
385                 390                 395                 400 


Pro Trp Val Thr Leu Ser Val Leu Gly Phe Leu Tyr Cys Tyr Ser His 
                405                 410                 415     


Val Gly Ile Ala Trp Ala Gln Thr Tyr Ala Thr Asp 
            420                 425             


<210>  2250
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  2250

Met Ala Gly Gly Arg Pro His Leu Lys Arg Ser Phe Ser Ile Ile Pro 
1               5                   10                  15      


Cys Phe Val Phe Val Glu Gly Phe Phe Cys Tyr Asp Ser Thr Tyr Ala 
            20                  25                  30          


Lys Pro Tyr Pro Gly Pro Glu Ala Ala Ser Arg Val Pro Pro Ala Leu 
        35                  40                  45              


Val Tyr Ala Leu Val Thr Ala Gly Pro Thr Leu Thr Ile Leu Leu Gly 
    50                  55                  60                  


Glu Leu Ala Arg Ala Phe Phe Pro Ala Pro Pro Ser Ala Val Pro Val 
65                  70                  75                  80  


Ile Gly Glu Ser Thr Ile Val Ser Gly Ala Cys Cys Arg Phe Ser Pro 
                85                  90                  95      


Pro Val Arg Arg Leu Val Arg Phe Leu Gly Val Tyr Ser Phe Gly Leu 
            100                 105                 110         


Phe Thr Thr Thr Ile Phe Ala Asn Ala Gly Gln Val Val Thr Gly Asn 
        115                 120                 125             


Pro Thr Pro His Phe Leu Ser Val Cys Arg Pro Asn Tyr Thr Ala Leu 
    130                 135                 140                 


Gly Cys Leu Pro Pro Ser Pro Asp Arg Pro Gly Pro Asp Arg Phe Val 
145                 150                 155                 160 


Thr Asp Gln Gly Ala Cys Ala Gly Ser Pro Ser Leu Val Ala Ala Ala 
                165                 170                 175     


Arg Arg Ala Phe Pro Cys Lys Asp Ala Ala Leu Cys Ala Tyr Ala Val 
            180                 185                 190         


Thr Tyr Thr Ala Met Tyr Val Thr Leu Val Phe Arg Val Lys Gly Ser 
        195                 200                 205             


Arg Leu Val Lys Pro Ser Leu Cys Leu Ala Leu Leu Cys Pro Ala Phe 
    210                 215                 220                 


Leu Val Gly Val Val Arg Val Ala Glu Tyr Arg Asn His Trp Ser Asp 
225                 230                 235                 240 


Val Leu Ala Gly Phe Leu Thr Gly Ala Ala Ile Ala Thr Phe Leu Val 
                245                 250                 255     


Thr Cys Val Val His Asn Phe Gln Ser Arg Pro Pro Ser Gly Arg Arg 
            260                 265                 270         


Leu Ser Pro Trp Glu Asp Leu Gly Gln Ala Pro Thr Met Asp Ser Pro 
        275                 280                 285             


Leu Glu Lys Leu Ser Val Ala Gln Glu Pro Glu Val Cys Arg Pro His 
    290                 295                 300                 


Ser Thr Pro Ala Arg Leu Thr Pro Ser Lys Ser Gln Asn Cys Ala Arg 
305                 310                 315                 320 


Arg Gly His Leu Ile Pro Ser Cys Val Ser Ser Arg Ala Pro Ala Met 
                325                 330                 335     


Cys Ser Ser Pro Arg Val Pro Arg Pro Arg Leu Arg Ser Glu Pro Thr 
            340                 345                 350         


Pro Leu Pro Leu Pro Leu Pro Leu Pro Ala Pro Thr Pro Ser Gln Gly 
        355                 360                 365             


Pro Ser Pro Ser Ser Pro Gly Pro Gly Gly Pro Gly Gly Gly Gly Gly 
    370                 375                 380                 


Arg Gly Arg Lys Leu Leu Leu Pro Thr Pro Leu Leu Arg Asp Leu Tyr 
385                 390                 395                 400 


Thr Leu Ser Gly Leu Tyr Pro Ser Pro Phe His Arg Asp Asn Phe Ser 
                405                 410                 415     


Pro Tyr Leu Phe Ala Ser Arg Asp His Leu Leu 
            420                 425         


<210>  2251
<211>  807
<212>  PRT
<213>  Homo sapiens

<400>  2251

Met Gly Val Ala Gly Arg Asn Arg Pro Gly Ala Ala Trp Ala Val Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Pro Pro Leu Leu Leu Leu Ala Gly Ala Val 
            20                  25                  30          


Pro Pro Gly Arg Gly Arg Ala Ala Gly Pro Gln Glu Asp Val Asp Glu 
        35                  40                  45              


Cys Ala Gln Gly Leu Asp Asp Cys His Ala Asp Ala Leu Cys Gln Asn 
    50                  55                  60                  


Thr Pro Thr Ser Tyr Lys Cys Ser Cys Lys Pro Gly Tyr Gln Gly Glu 
65                  70                  75                  80  


Gly Arg Gln Cys Glu Asp Ile Asp Glu Cys Gly Asn Glu Leu Asn Gly 
                85                  90                  95      


Gly Cys Val His Asp Cys Leu Asn Ile Pro Gly Asn Tyr Arg Cys Thr 
            100                 105                 110         


Cys Phe Asp Gly Phe Met Leu Ala His Asp Gly His Asn Cys Leu Asp 
        115                 120                 125             


Val Asp Glu Cys Leu Glu Asn Asn Gly Gly Cys Gln His Thr Cys Val 
    130                 135                 140                 


Asn Val Met Gly Ser Tyr Glu Cys Cys Cys Lys Glu Gly Phe Phe Leu 
145                 150                 155                 160 


Ser Asp Asn Gln His Thr Cys Ile His Arg Ser Glu Glu Gly Leu Ser 
                165                 170                 175     


Cys Met Asn Lys Asp His Gly Cys Ser His Ile Cys Lys Glu Ala Pro 
            180                 185                 190         


Arg Gly Ser Val Ala Cys Glu Cys Arg Pro Gly Phe Glu Leu Ala Lys 
        195                 200                 205             


Asn Gln Arg Asp Cys Ile Leu Thr Cys Asn His Gly Asn Gly Gly Cys 
    210                 215                 220                 


Gln His Ser Cys Asp Asp Thr Ala Asp Gly Pro Glu Cys Ser Cys His 
225                 230                 235                 240 


Pro Gln Tyr Lys Met His Thr Asp Gly Arg Ser Cys Leu Glu Arg Glu 
                245                 250                 255     


Asp Thr Val Leu Glu Val Thr Glu Ser Asn Thr Thr Ser Val Val Asp 
            260                 265                 270         


Gly Asp Lys Arg Val Lys Arg Arg Leu Leu Met Glu Thr Cys Ala Val 
        275                 280                 285             


Asn Asn Gly Gly Cys Asp Arg Thr Cys Lys Asp Thr Ser Thr Gly Val 
    290                 295                 300                 


His Cys Ser Cys Pro Val Gly Phe Thr Leu Gln Leu Asp Gly Lys Thr 
305                 310                 315                 320 


Cys Lys Asp Ile Asp Glu Cys Gln Thr Arg Asn Gly Gly Cys Asp His 
                325                 330                 335     


Phe Cys Lys Asn Ile Val Gly Ser Phe Asp Cys Gly Cys Lys Lys Gly 
            340                 345                 350         


Phe Lys Leu Leu Thr Asp Glu Lys Ser Cys Gln Asp Val Asp Glu Cys 
        355                 360                 365             


Ser Leu Asp Arg Thr Cys Asp His Ser Cys Ile Asn His Pro Gly Thr 
    370                 375                 380                 


Phe Ala Cys Ala Cys Asn Arg Gly Tyr Thr Leu Tyr Gly Phe Thr His 
385                 390                 395                 400 


Cys Gly Asp Thr Asn Glu Cys Ser Ile Asn Asn Gly Gly Cys Gln Gln 
                405                 410                 415     


Val Cys Val Asn Thr Val Gly Ser Tyr Glu Cys Gln Cys His Pro Gly 
            420                 425                 430         


Tyr Lys Leu His Trp Asn Lys Lys Asp Cys Val Ala Ser Cys Asp Leu 
        435                 440                 445             


Ser Cys Ile Val Lys Arg Thr Glu Lys Arg Leu Arg Lys Ala Ile Arg 
    450                 455                 460                 


Thr Leu Arg Lys Ala Val His Arg Glu Gln Phe His Leu Gln Leu Ser 
465                 470                 475                 480 


Gly Met Asn Leu Asp Val Ala Lys Lys Pro Pro Arg Thr Ser Glu Arg 
                485                 490                 495     


Gln Ala Glu Ser Cys Gly Val Gly Gln Gly His Ala Glu Asn Gln Cys 
            500                 505                 510         


Val Ser Cys Arg Ala Gly Thr Tyr Tyr Asp Gly Ala Arg Glu Arg Cys 
        515                 520                 525             


Ile Leu Cys Pro Asn Gly Thr Phe Gln Asn Glu Glu Gly Gln Met Thr 
    530                 535                 540                 


Cys Glu Pro Cys Pro Arg Pro Gly Asn Ser Gly Ala Leu Lys Thr Pro 
545                 550                 555                 560 


Glu Ala Trp Asn Met Ser Glu Cys Gly Gly Leu Cys Gln Pro Gly Glu 
                565                 570                 575     


Tyr Ser Ala Asp Gly Phe Ala Pro Cys Gln Leu Cys Ala Leu Gly Thr 
            580                 585                 590         


Phe Gln Pro Glu Ala Gly Arg Thr Ser Cys Phe Pro Cys Gly Gly Gly 
        595                 600                 605             


Leu Ala Thr Lys His Gln Gly Ala Thr Ser Phe Gln Asp Cys Glu Thr 
    610                 615                 620                 


Arg Val Gln Cys Ser Pro Gly His Phe Tyr Asn Thr Thr Thr His Arg 
625                 630                 635                 640 


Cys Ile Arg Cys Pro Val Gly Thr Tyr Gln Pro Glu Phe Gly Lys Asn 
                645                 650                 655     


Asn Cys Val Ser Cys Pro Gly Asn Thr Thr Thr Asp Phe Asp Gly Ser 
            660                 665                 670         


Thr Asn Ile Thr Gln Cys Lys Thr Ser Ser Asn Ser Val Thr Thr Tyr 
        675                 680                 685             


Glu Thr Cys Gln Thr Tyr Glu Arg Pro Ile Ala Phe Thr Ser Arg Ser 
    690                 695                 700                 


Lys Lys Leu Trp Ile Gln Phe Lys Ser Asn Glu Gly Asn Ser Ala Arg 
705                 710                 715                 720 


Gly Phe Gln Val Pro Tyr Val Thr Tyr Asp Glu Asp Tyr Gln Glu Leu 
                725                 730                 735     


Ile Glu Asp Ile Val Arg Asp Gly Arg Leu Tyr Ala Ser Glu Asn His 
            740                 745                 750         


Gln Glu Ile Leu Lys Asp Lys Lys Leu Ile Lys Ala Leu Phe Asp Val 
        755                 760                 765             


Leu Ala His Pro Gln Asn Tyr Phe Lys Tyr Thr Ala Gln Glu Ser Arg 
    770                 775                 780                 


Glu Met Phe Pro Arg Ser Phe Ile Arg Leu Leu Arg Ser Lys Val Ser 
785                 790                 795                 800 


Arg Phe Leu Arg Pro Tyr Lys 
                805         


<210>  2252
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  2252

Met Leu Trp Ala Val Arg Thr Arg Cys Tyr Val Val Lys Ala Gln Leu 
1               5                   10                  15      


Gly Pro Thr Val Ala Leu Glu Gly Arg Ala Pro Arg Ala Pro Gly Pro 
            20                  25                  30          


Ser Cys Leu Gly Asn Gly Asn Cys Gln Arg Pro Gly Pro Ile Thr Ser 
        35                  40                  45              


Arg Asn Val Thr Arg Ala Ser Leu Pro Asp Met Glu Ser Asn Leu Ser 
    50                  55                  60                  


Gly Leu Val Pro Ala Ala Gly Leu Val Pro Ala Leu Pro Pro Ala Val 
65                  70                  75                  80  


Thr Leu Gly Leu Thr Ala Ala Tyr Thr Thr Leu Tyr Ala Leu Leu Phe 
                85                  90                  95      


Phe Ser Val Tyr Ala Gln Leu Trp Leu Val Leu Leu Tyr Gly His Lys 
            100                 105                 110         


Arg Leu Ser Tyr Gln Thr Val Phe Leu Ala Leu Cys Leu Leu Trp Ala 
        115                 120                 125             


Ala Leu Arg Thr Thr Leu Phe Ser Phe Tyr Phe Arg Asp Thr Pro Arg 
    130                 135                 140                 


Ala Asn Arg Leu Gly Pro Leu Pro Phe Trp Leu Leu Tyr Cys Cys Pro 
145                 150                 155                 160 


Val Cys Leu Gln Phe Phe Thr Leu Thr Leu Met Asn Leu Tyr Phe Ala 
                165                 170                 175     


Gln Val Val Phe Lys Ala Lys Val Lys Arg Arg Pro Glu Met Ser Arg 
            180                 185                 190         


Gly Leu Leu Ala Val Arg Gly Ala Phe Val Gly Ala Ser Leu Leu Phe 
        195                 200                 205             


Leu Leu Val Asn Val Leu Cys Ala Val Leu Ser His Arg Arg Arg Ala 
    210                 215                 220                 


Gln Pro Trp Ala Leu Leu Leu Val Arg Val Leu Val Ser Asp Ser Leu 
225                 230                 235                 240 


Phe Val Ile Cys Ala Leu Ser Leu Ala Ala Cys Leu Cys Leu Val Ala 
                245                 250                 255     


Arg Arg Ala Pro Ser Thr Ser Ile Tyr Leu Glu Ala Lys Gly Thr Ser 
            260                 265                 270         


Val Cys Gln Ala Ala Ala Met Gly Gly Ala Met Val Leu Leu Tyr Ala 
        275                 280                 285             


Ser Arg Ala Cys Tyr Asn Leu Thr Ala Leu Ala Leu Ala Pro Gln Ser 
    290                 295                 300                 


Arg Leu Asp Thr Phe Asp Tyr Asp Trp Tyr Asn Val Ser Asp Gln Ala 
305                 310                 315                 320 


Asp Leu Val Asn Asp Leu Gly Asn Lys Gly Tyr Leu Val Phe Gly Leu 
                325                 330                 335     


Ile Leu Phe Val Trp Glu Leu Leu Pro Thr Thr Leu Leu Val Gly Phe 
            340                 345                 350         


Phe Arg Val His Arg Pro Pro Gln Asp Leu Ser Thr Ser His Ile Leu 
        355                 360                 365             


Asn Gly Gln Val Phe Ala Ser Arg Ser Tyr Phe Phe Asp Arg Ala Gly 
    370                 375                 380                 


His Cys Glu Asp Glu Gly Cys Ser Trp Glu His Ser Arg Gly Glu Ser 
385                 390                 395                 400 


Thr Arg Cys Gln Asp Gln Ala Ala Thr Thr Thr Val Ser Thr Pro Pro 
                405                 410                 415     


His Arg Arg Asp Pro Pro Pro Ser Pro Thr Glu Tyr Pro Gly Pro Ser 
            420                 425                 430         


Pro Pro His Pro Arg Pro Leu Cys Gln Val Cys Leu Pro Leu Leu Ala 
        435                 440                 445             


Gln Asp Pro Gly Gly Arg Gly Tyr Pro Leu Leu Trp Pro Ala Pro Cys 
    450                 455                 460                 


Cys Ser Cys His Ser Glu Leu Val Pro Ser Pro 
465                 470                 475 


<210>  2253
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  2253

Met Pro Tyr Ser Thr Asn Lys Glu Leu Ile Leu Gly Ile Met Val Gly 
1               5                   10                  15      


Thr Ala Gly Ile Ser Leu Leu Leu Leu Trp Tyr His Lys Val Arg Lys 
            20                  25                  30          


Pro Gly Ile Ala Met Lys Leu Pro Glu Phe Leu Ser Leu Gly Asn Thr 
        35                  40                  45              


Phe Asn Ser Ile Thr Leu Gln Asp Glu Ile His Asp Asp Gln Gly Thr 
    50                  55                  60                  


Thr Val Ile Phe Gln Glu Arg Gln Leu Gln Ile Leu Glu Lys Leu Asn 
65                  70                  75                  80  


Glu Leu Leu Thr Asn Met Glu Glu Leu Lys Glu Glu Ile Arg Phe Leu 
                85                  90                  95      


Lys Glu Ala Ile Pro Lys Leu Glu Glu Tyr Ile Gln Asp Glu Leu Gly 
            100                 105                 110         


Gly Lys Ile Thr Val His Lys Ile Ser Pro Gln His Arg Ala Arg Lys 
        115                 120                 125             


Arg Arg Leu Pro Thr Ile Gln Ser Ser Ala Thr Ser Asn Ser Ser Glu 
    130                 135                 140                 


Glu Ala Glu Ser Glu Gly Gly Tyr Ile Thr Ala Asn Thr Asp Thr Glu 
145                 150                 155                 160 


Glu Gln Ser Phe Pro Val Pro Lys Ala Phe Asn Thr Arg Val Glu Glu 
                165                 170                 175     


Leu Asn Leu Asp Val Leu Leu Gln Lys Val Asp His Leu Arg Met Ser 
            180                 185                 190         


Glu Ser Gly Lys Ser Glu Ser Phe Glu Leu Leu Arg Asp His Lys Glu 
        195                 200                 205             


Lys Phe Arg Asp Glu Ile Glu Phe Met Trp Arg Phe Ala Arg Ala Tyr 
    210                 215                 220                 


Gly Asp Met Tyr Glu Leu Ser Thr Asn Thr Gln Glu Lys Lys His Tyr 
225                 230                 235                 240 


Ala Asn Ile Gly Lys Thr Leu Ser Glu Arg Ala Ile Asn Arg Ala Pro 
                245                 250                 255     


Met Asn Gly His Cys His Leu Trp Tyr Ala Val Leu Cys Gly Tyr Val 
            260                 265                 270         


Ser Glu Phe Glu Gly Leu Gln Asn Lys Ile Asn Tyr Gly His Leu Phe 
        275                 280                 285             


Lys Glu His Leu Asp Ile Ala Ile Lys Leu Leu Pro Glu Glu Pro Phe 
    290                 295                 300                 


Leu Tyr Tyr Leu Lys Gly Arg Tyr Cys Tyr Thr Val Ser Lys Leu Ser 
305                 310                 315                 320 


Trp Ile Glu Lys Lys Met Ala Ala Thr Leu Phe Gly Lys Ile Pro Ser 
                325                 330                 335     


Ser Thr Val Gln Glu Ala Leu His Asn Phe Leu Lys Ala Glu Glu Leu 
            340                 345                 350         


Cys Pro Gly Tyr Ser Asn Pro Asn Tyr Met Tyr Leu Ala Lys Cys Tyr 
        355                 360                 365             


Thr Asp Leu Glu Glu Asn Gln Asn Ala Leu Lys Phe Cys Asn Leu Ala 
    370                 375                 380                 


Leu Leu Leu Pro Thr Val Thr Lys Glu Asp Lys Glu Ala Gln Lys Glu 
385                 390                 395                 400 


Met Gln Lys Ile Met Thr Ser Leu Lys Arg 
                405                 410 


<210>  2254
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  2254

Met Pro Tyr Ser Thr Asn Lys Glu Leu Ile Leu Gly Ile Met Val Gly 
1               5                   10                  15      


Thr Ala Gly Ile Ser Leu Leu Leu Leu Trp Tyr His Lys Val Arg Lys 
            20                  25                  30          


Pro Gly Ile Ala Met Lys Leu Pro Glu Phe Leu Ser Leu Gly Asn Thr 
        35                  40                  45              


Phe Asn Ser Ile Thr Leu Gln Asp Glu Ile His Asp Asp Gln Gly Thr 
    50                  55                  60                  


Thr Val Ile Phe Gln Glu Arg Gln Leu Gln Ile Leu Glu Lys Leu Asn 
65                  70                  75                  80  


Glu Leu Leu Thr Asn Met Glu Glu Leu Lys Glu Glu Ile Arg Phe Leu 
                85                  90                  95      


Lys Glu Ala Ile Pro Lys Leu Glu Glu Tyr Ile Gln Asp Glu Leu Gly 
            100                 105                 110         


Gly Lys Ile Thr Val His Lys Ile Ser Pro Gln His Arg Ala Arg Lys 
        115                 120                 125             


Arg Arg Leu Pro Thr Ile Gln Ser Ser Ala Thr Ser Asn Ser Ser Glu 
    130                 135                 140                 


Glu Ala Glu Ser Glu Gly Gly Tyr Ile Thr Ala Asn Thr Asp Thr Glu 
145                 150                 155                 160 


Glu Gln Ser Phe Pro Val Pro Lys Ala Phe Asn Thr Arg Val Glu Glu 
                165                 170                 175     


Leu Asn Leu Asp Val Leu Leu Gln Lys Val Asp His Leu Arg Met Ser 
            180                 185                 190         


Glu Ser Gly Lys Ser Glu Ser Phe Glu Leu Leu Arg Asp His Lys Glu 
        195                 200                 205             


Lys Phe Arg Asp Glu Ile Glu Phe Met Trp Arg Phe Ala Arg Ala Tyr 
    210                 215                 220                 


Gly Asp Met Tyr Glu Leu Ser Thr Asn Thr Gln Glu Lys Lys His Tyr 
225                 230                 235                 240 


Ala Asn Ile Gly Lys Thr Leu Ser Glu Arg Ala Ile Asn Arg Ala Pro 
                245                 250                 255     


Met Asn Gly His Cys His Leu Trp Tyr Ala Val Leu Cys Gly Tyr Val 
            260                 265                 270         


Ser Glu Phe Glu Gly Leu Gln Asn Lys Ile Asn Tyr Gly His Leu Phe 
        275                 280                 285             


Lys Glu His Leu Asp Ile Ala Ile Lys Leu Leu Pro Glu Glu Pro Phe 
    290                 295                 300                 


Leu Tyr Tyr Leu Lys Gly Arg Tyr Cys Tyr Thr Val Ser Lys Leu Ser 
305                 310                 315                 320 


Trp Ile Glu Lys Lys Met Ala Ala Thr Leu Phe Gly Lys Ile Pro Ser 
                325                 330                 335     


Ser Thr Val Gln Glu Ala Leu His Asn Phe Leu Lys Ala Glu Glu Leu 
            340                 345                 350         


Cys Pro Gly Tyr Ser Asn Pro Asn Tyr Met Tyr Leu Ala Lys Cys Tyr 
        355                 360                 365             


Thr Asp Leu Glu Glu Asn Gln Asn Ala Leu Lys Phe Cys Asn Leu Ala 
    370                 375                 380                 


Leu Leu Leu Pro Thr Val Thr Lys Glu Asp Lys Glu Ala Gln Lys Glu 
385                 390                 395                 400 


Met Gln Lys Ile Met Thr Ser Leu Lys Arg 
                405                 410 


<210>  2255
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  2255

Met Gly Lys Cys Leu Arg Tyr Ile Thr Ala Asn Thr Asp Thr Glu Glu 
1               5                   10                  15      


Gln Ser Phe Pro Val Pro Lys Ala Phe Asn Thr Arg Val Glu Glu Leu 
            20                  25                  30          


Asn Leu Asp Val Leu Leu Gln Lys Val Asp His Leu Arg Met Ser Glu 
        35                  40                  45              


Ser Gly Lys Ser Glu Ser Phe Glu Leu Leu Arg Asp His Lys Glu Lys 
    50                  55                  60                  


Phe Arg Asp Glu Ile Glu Phe Met Trp Arg Phe Ala Arg Ala Tyr Gly 
65                  70                  75                  80  


Asp Met Tyr Glu Leu Ser Thr Asn Thr Gln Glu Lys Lys His Tyr Ala 
                85                  90                  95      


Asn Ile Gly Lys Thr Leu Ser Glu Arg Ala Ile Asn Arg Ala Pro Met 
            100                 105                 110         


Asn Gly His Cys His Leu Trp Tyr Ala Val Leu Cys Gly Tyr Val Ser 
        115                 120                 125             


Glu Phe Glu Gly Leu Gln Asn Lys Ile Asn Tyr Gly His Leu Phe Lys 
    130                 135                 140                 


Glu His Leu Asp Ile Ala Ile Lys Leu Leu Pro Glu Glu Pro Phe Leu 
145                 150                 155                 160 


Tyr Tyr Leu Lys Gly Arg Tyr Cys Tyr Thr Val Ser Lys Leu Ser Trp 
                165                 170                 175     


Ile Glu Lys Lys Met Ala Ala Thr Leu Phe Gly Lys Ile Pro Ser Ser 
            180                 185                 190         


Thr Val Gln Glu Ala Leu His Asn Phe Leu Lys Ala Glu Glu Leu Cys 
        195                 200                 205             


Pro Gly Tyr Ser Asn Pro Asn Tyr Met Tyr Leu Ala Lys Cys Tyr Thr 
    210                 215                 220                 


Asp Leu Glu Glu Asn Gln Asn Ala Leu Lys Phe Cys Asn Leu Ala Leu 
225                 230                 235                 240 


Leu Leu Pro Thr Val Thr Lys Glu Asp Lys Glu Ala Gln Lys Glu Met 
                245                 250                 255     


Gln Lys Ile Met Thr Ser Leu Lys Arg 
            260                 265 


<210>  2256
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  2256

Met Ala Pro His Asp Pro Gly Ser Leu Thr Thr Leu Val Pro Trp Ala 
1               5                   10                  15      


Ala Ala Leu Leu Leu Ala Leu Gly Val Glu Arg Ala Leu Ala Leu Pro 
            20                  25                  30          


Glu Ile Cys Thr Gln Cys Pro Gly Ser Val Gln Asn Leu Ser Lys Val 
        35                  40                  45              


Ala Phe Tyr Cys Lys Thr Thr Arg Glu Leu Met Leu His Ala Arg Cys 
    50                  55                  60                  


Cys Leu Asn Gln Lys Gly Thr Ile Leu Gly Leu Asp Leu Gln Asn Cys 
65                  70                  75                  80  


Ser Leu Glu Asp Pro Gly Pro Asn Phe His Gln Ala His Thr Thr Val 
                85                  90                  95      


Ile Ile Asp Leu Gln Ala Asn Pro Leu Lys Gly Asp Leu Ala Asn Thr 
            100                 105                 110         


Phe Arg Gly Phe Thr Gln Leu Gln Thr Leu Ile Leu Pro Gln His Val 
        115                 120                 125             


Asn Cys Pro Gly Gly Ile Asn Ala Trp Asn Thr Ile Thr Ser Tyr Ile 
    130                 135                 140                 


Asp Asn Gln Ile Cys Gln Gly Gln Lys Asn Leu Cys Asn Asn Thr Gly 
145                 150                 155                 160 


Asp Pro Glu Met Cys Pro Glu Asn Gly Ser Cys Val Pro Asp Gly Pro 
                165                 170                 175     


Gly Leu Leu Gln Cys Val Cys Ala Asp Gly Phe His Gly Tyr Lys Cys 
            180                 185                 190         


Met Arg Gln Gly Ser Phe Ser Leu Leu Met Phe Phe Gly Ile Leu Gly 
        195                 200                 205             


Ala Thr Thr Leu Ser Val Ser Ile Leu Leu Trp Ala Thr Gln Arg Arg 
    210                 215                 220                 


Lys Ala Lys Thr Ser 
225                 


<210>  2257
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  2257

Met Arg Glu Gly Lys Arg Gly Pro Pro Cys Ile Leu Ser Phe Arg Gly 
1               5                   10                  15      


Thr Leu Glu Arg Val Glu Ala Gln Trp Glu Leu Glu Ala Gln Gly Pro 
            20                  25                  30          


Gly Gln Cys Pro Ala Pro Leu Gly Asp Pro Ala Ser Thr Thr Asp Gly 
        35                  40                  45              


Ala Gln Glu Ala Arg Val Pro Leu Asp Gly Ala Phe Trp Ile Pro Arg 
    50                  55                  60                  


Pro Pro Ala Gly Ser Pro Lys Gly Cys Phe Ala Cys Val Ser Lys Pro 
65                  70                  75                  80  


Pro Ala Leu Gln Ala Pro Ala Ala Pro Ala Pro Glu Pro Ser Ala Ser 
                85                  90                  95      


Pro Pro Met Ala Pro Thr Leu Phe Pro Met Glu Ser Lys Ser Ser Lys 
            100                 105                 110         


Thr Asp Ser Val Arg Ala Ala Gly Ala Pro Pro Ala Cys Lys His Leu 
        115                 120                 125             


Ala Glu Lys Lys Thr Met Thr Asn Pro Thr Thr Val Ile Glu Val Tyr 
    130                 135                 140                 


Pro Asp Thr Thr Glu Val Asn Asp Tyr Tyr Leu Trp Ser Ile Phe Asn 
145                 150                 155                 160 


Phe Val Tyr Leu Asn Phe Cys Cys Leu Gly Phe Ile Ala Leu Ala Tyr 
                165                 170                 175     


Ser Leu Lys Val Arg Asp Lys Lys Leu Leu Asn Asp Leu Asn Gly Ala 
            180                 185                 190         


Val Glu Asp Ala Lys Thr Ala Arg Leu Phe Asn Ile Thr Ser Ser Ala 
        195                 200                 205             


Leu Ala Ala Ser Cys Ile Ile Leu Val Phe Ile Phe Leu Arg Tyr Pro 
    210                 215                 220                 


Leu Thr Asp Tyr 
225             


<210>  2258
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  2258

Met Glu Ser Asn Leu Ser Gly Leu Val Pro Ala Ala Gly Leu Val Pro 
1               5                   10                  15      


Ala Leu Pro Pro Ala Val Thr Leu Gly Leu Thr Ala Ala Tyr Thr Thr 
            20                  25                  30          


Leu Tyr Ala Leu Leu Phe Phe Ser Val Tyr Ala Gln Leu Trp Leu Val 
        35                  40                  45              


Leu Leu Tyr Gly His Lys Arg Leu Ser Tyr Gln Thr Val Phe Leu Ala 
    50                  55                  60                  


Leu Cys Leu Leu Trp Ala Ala Leu Arg Thr Thr Leu Phe Ser Phe Tyr 
65                  70                  75                  80  


Phe Arg Asp Thr Pro Arg Ala Asn Arg Leu Gly Pro Leu Pro Phe Trp 
                85                  90                  95      


Leu Leu Tyr Cys Cys Pro Val Cys Leu Gln Phe Phe Thr Leu Thr Leu 
            100                 105                 110         


Met Asn Leu Tyr Phe Ala Gln Val Val Phe Lys Ala Lys Val Lys Arg 
        115                 120                 125             


Arg Pro Glu Met Ser Arg Gly Leu Leu Ala Val Arg Gly Ala Phe Val 
    130                 135                 140                 


Gly Ala Ser Leu Leu Phe Leu Leu Val Asn Val Leu Cys Ala Val Leu 
145                 150                 155                 160 


Ser His Arg Arg Arg Ala Gln Pro Trp Ala Leu Leu Leu Val Arg Val 
                165                 170                 175     


Leu Val Ser Asp Ser Leu Phe Val Ile Cys Ala Leu Ser Leu Ala Ala 
            180                 185                 190         


Cys Leu Cys Leu Val Ala Arg Arg Ala Pro Ser Thr Ser Ile Tyr Leu 
        195                 200                 205             


Glu Ala Lys Gly Thr Ser Val Cys Gln Ala Ala Ala Met Gly Gly Ala 
    210                 215                 220                 


Met Val Leu Leu Tyr Ala Ser Arg Ala Cys Tyr Asn Leu Thr Ala Leu 
225                 230                 235                 240 


Ala Leu Ala Pro Gln Ser Arg Leu Asp Thr Phe Asp Tyr Asp Trp Tyr 
                245                 250                 255     


Asn Val Ser Asp Gln Ala Asp Leu Val Asn Asp Leu Gly Asn Lys Gly 
            260                 265                 270         


Tyr Leu Val Phe Gly Leu Ile Leu Phe Val Trp Glu Leu Leu Pro Thr 
        275                 280                 285             


Thr Leu Leu Val Gly Phe Phe Arg Val His Arg Pro Pro Gln Asp Leu 
    290                 295                 300                 


Ser Thr Ser His Ile Leu Asn Gly Gln Val Phe Ala Ser Arg Ser Tyr 
305                 310                 315                 320 


Phe Phe Asp Arg Ala Gly His Cys Glu Asp Glu Gly Cys Ser Trp Glu 
                325                 330                 335     


His Ser Arg Gly Glu Ser Thr Ser Met Ser Gly Ser Leu Gly Ser Gly 
            340                 345                 350         


Ser Trp Tyr Gly Ala Ile Gly Arg Glu Pro Gly Trp Tyr Gly Gly Ser 
        355                 360                 365             


Gln Thr Lys Thr Thr Pro Leu Leu Phe Ser Gln Val Pro Gly Pro Gly 
    370                 375                 380                 


Gly His His His Ser Leu Tyr Ser Thr Pro Gln Thr 
385                 390                 395     


<210>  2259
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  2259

Met Glu Ser Asn Leu Ser Gly Leu Val Pro Ala Ala Gly Leu Val Pro 
1               5                   10                  15      


Ala Leu Pro Pro Ala Val Thr Leu Gly Leu Thr Ala Ala Tyr Thr Thr 
            20                  25                  30          


Leu Tyr Ala Leu Leu Phe Phe Ser Val Tyr Ala Gln Leu Trp Leu Val 
        35                  40                  45              


Leu Leu Tyr Gly His Lys Arg Leu Ser Tyr Gln Thr Val Phe Leu Ala 
    50                  55                  60                  


Leu Cys Leu Leu Trp Ala Ala Leu Arg Thr Thr Leu Phe Ser Phe Tyr 
65                  70                  75                  80  


Phe Arg Asp Thr Pro Arg Ala Asn Arg Leu Gly Pro Leu Pro Phe Trp 
                85                  90                  95      


Leu Leu Tyr Cys Cys Pro Val Cys Leu Gln Phe Phe Thr Leu Thr Leu 
            100                 105                 110         


Met Asn Leu Tyr Phe Ala Gln Val Val Phe Lys Ala Lys Val Lys Arg 
        115                 120                 125             


Arg Pro Glu Met Ser Arg Gly Leu Leu Ala Val Arg Gly Ala Phe Val 
    130                 135                 140                 


Gly Ala Ser Leu Leu Phe Leu Leu Val Asn Val Leu Cys Ala Val Leu 
145                 150                 155                 160 


Ser His Arg Arg Arg Ala Gln Pro Trp Ala Leu Leu Leu Val Arg Val 
                165                 170                 175     


Leu Val Ser Asp Ser Leu Phe Val Ile Cys Ala Leu Ser Leu Ala Ala 
            180                 185                 190         


Cys Leu Cys Leu Val Ala Arg Arg Ala Pro Ser Thr Ser Ile Tyr Leu 
        195                 200                 205             


Glu Ala Lys Ala Asp Leu Val Asn Asp Leu Gly Asn Lys Gly Tyr Leu 
    210                 215                 220                 


Val Phe Gly Leu Ile Leu Phe Val Trp Glu Leu Leu Pro Thr Thr Leu 
225                 230                 235                 240 


Leu Val Gly Phe Phe Arg Val His Arg Pro Pro Gln Asp Leu Ser Thr 
                245                 250                 255     


Ser His Ile Leu Asn Gly Gln Val Phe Ala Ser Arg Ser Tyr Phe Phe 
            260                 265                 270         


Asp Arg Ala Gly His Cys Glu Asp Glu Gly Cys Ser Trp Glu His Ser 
        275                 280                 285             


Arg Gly Glu Ser Thr Ser Met Ser Gly Ser Leu Gly Ser Gly Ser Trp 
    290                 295                 300                 


Tyr Gly Ala Ile Gly Arg Glu Pro Gly Trp Tyr Gly Gly Ser Gln Thr 
305                 310                 315                 320 


Lys Thr Thr Pro Leu Leu Phe Ser Gln Val Pro Gly Pro Gly Gly His 
                325                 330                 335     


His His Ser Leu Tyr Ser Thr Pro Gln Thr 
            340                 345     


<210>  2260
<211>  1341
<212>  PRT
<213>  Homo sapiens

<400>  2260

Met Thr Leu Asp Arg Pro Gly Glu Gly Ala Thr Met Leu Lys Thr Phe 
1               5                   10                  15      


Thr Val Leu Leu Phe Cys Ile Arg Met Ser Leu Gly Met Thr Ser Ile 
            20                  25                  30          


Val Met Asp Pro Gln Pro Glu Leu Trp Ile Glu Ser Asn Tyr Pro Gln 
        35                  40                  45              


Ala Pro Trp Glu Asn Ile Thr Leu Trp Cys Arg Ser Pro Ser Arg Ile 
    50                  55                  60                  


Ser Ser Lys Phe Leu Leu Leu Lys Asp Lys Thr Gln Met Thr Trp Ile 
65                  70                  75                  80  


Arg Pro Ser His Lys Thr Phe Gln Val Ser Phe Leu Ile Gly Ala Leu 
                85                  90                  95      


Thr Glu Ser Asn Ala Gly Leu Tyr Arg Cys Cys Tyr Trp Lys Glu Thr 
            100                 105                 110         


Gly Trp Ser Lys Pro Ser Lys Val Leu Glu Leu Glu Ala Pro Gly Gln 
        115                 120                 125             


Leu Pro Lys Pro Ile Phe Trp Ile Gln Ala Glu Thr Pro Ala Leu Pro 
    130                 135                 140                 


Gly Cys Asn Val Asn Ile Leu Cys His Gly Trp Leu Gln Asp Leu Val 
145                 150                 155                 160 


Phe Met Leu Phe Lys Glu Gly Tyr Ala Glu Pro Val Asp Tyr Gln Val 
                165                 170                 175     


Pro Thr Gly Thr Met Ala Ile Phe Ser Ile Asp Asn Leu Thr Pro Glu 
            180                 185                 190         


Asp Glu Gly Val Tyr Ile Cys Arg Thr His Ile Gln Met Leu Pro Thr 
        195                 200                 205             


Leu Trp Ser Glu Pro Ser Asn Pro Leu Lys Leu Val Val Ala Gly Leu 
    210                 215                 220                 


Tyr Pro Lys Pro Thr Leu Thr Ala His Pro Gly Pro Ile Met Ala Pro 
225                 230                 235                 240 


Gly Glu Ser Leu Asn Leu Arg Cys Gln Gly Pro Ile Tyr Gly Met Thr 
                245                 250                 255     


Phe Ala Leu Met Arg Val Glu Asp Leu Glu Lys Ser Phe Tyr His Lys 
            260                 265                 270         


Lys Thr Ile Lys Asn Glu Ala Asn Phe Phe Phe Gln Ser Leu Lys Ile 
        275                 280                 285             


Gln Asp Thr Gly His Tyr Leu Cys Phe Tyr Tyr Asp Ala Ser Tyr Arg 
    290                 295                 300                 


Gly Ser Leu Leu Ser Asp Val Leu Lys Ile Trp Val Thr Asp Thr Phe 
305                 310                 315                 320 


Pro Lys Thr Trp Leu Leu Ala Arg Pro Ser Ala Val Val Gln Met Gly 
                325                 330                 335     


Gln Asn Val Ser Leu Arg Cys Arg Gly Pro Val Asp Gly Val Gly Leu 
            340                 345                 350         


Ala Leu Tyr Lys Lys Gly Glu Asp Lys Pro Leu Gln Phe Leu Asp Ala 
        355                 360                 365             


Thr Ser Ile Asp Asp Asn Thr Ser Phe Phe Leu Asn Asn Val Thr Tyr 
    370                 375                 380                 


Ser Asp Thr Gly Ile Tyr Ser Cys His Tyr Leu Leu Thr Trp Lys Thr 
385                 390                 395                 400 


Ser Ile Arg Met Pro Ser His Asn Thr Val Glu Leu Met Val Val Asp 
                405                 410                 415     


Lys Pro Pro Lys Pro Ser Leu Ser Ala Trp Pro Ser Thr Val Phe Lys 
            420                 425                 430         


Leu Gly Lys Ala Ile Thr Leu Gln Cys Arg Val Ser His Pro Val Leu 
        435                 440                 445             


Glu Phe Ser Leu Glu Trp Glu Glu Arg Glu Thr Phe Gln Lys Phe Ser 
    450                 455                 460                 


Val Asn Gly Asp Phe Ile Ile Ser Asn Val Asp Gly Lys Gly Thr Gly 
465                 470                 475                 480 


Thr Tyr Ser Cys Ser Tyr Arg Val Glu Thr His Pro Asn Ile Trp Ser 
                485                 490                 495     


His Arg Ser Glu Pro Leu Lys Leu Met Gly Pro Ala Gly Tyr Leu Thr 
            500                 505                 510         


Trp Asn Tyr Val Leu Asn Glu Ala Ile Arg Leu Ser Leu Ile Met Gln 
        515                 520                 525             


Leu Val Ala Leu Leu Leu Val Val Leu Trp Ile Arg Trp Lys Cys Arg 
    530                 535                 540                 


Arg Leu Arg Ile Arg Glu Ala Trp Leu Leu Gly Thr Ala Gln Gly Val 
545                 550                 555                 560 


Thr Met Leu Phe Ile Val Thr Ala Leu Leu Cys Cys Ala Ile Ser Phe 
                565                 570                 575     


Ala Gly Leu Cys Asn Gly Val Leu Ile Glu Glu Thr Glu Ile Val Met 
            580                 585                 590         


Pro Thr Pro Lys Pro Glu Leu Trp Ala Glu Thr Asn Phe Pro Leu Ala 
        595                 600                 605             


Pro Trp Lys Asn Leu Thr Leu Trp Cys Arg Ser Pro Ser Gly Ser Thr 
    610                 615                 620                 


Lys Glu Phe Val Leu Leu Lys Asp Gly Thr Gly Trp Ile Ala Thr Arg 
625                 630                 635                 640 


Pro Ala Ser Glu Gln Val Arg Ala Ala Phe Pro Leu Gly Ala Leu Thr 
                645                 650                 655     


Gln Ser His Thr Gly Ser Tyr His Cys His Ser Trp Glu Glu Met Ala 
            660                 665                 670         


Val Ser Glu Pro Ser Glu Ala Leu Glu Leu Val Gly Thr Asp Ile Leu 
        675                 680                 685             


Pro Lys Pro Val Ile Ser Ala Ser Pro Thr Ile Arg Gly Gln Glu Leu 
    690                 695                 700                 


Gln Leu Arg Cys Lys Gly Trp Leu Ala Gly Met Gly Phe Ala Leu Tyr 
705                 710                 715                 720 


Lys Glu Gly Glu Gln Glu Pro Val Gln Gln Leu Gly Ala Val Gly Arg 
                725                 730                 735     


Glu Ala Phe Phe Thr Ile Gln Arg Met Glu Asp Lys Asp Glu Gly Asn 
            740                 745                 750         


Tyr Ser Cys Arg Thr His Thr Glu Lys Arg Pro Phe Lys Trp Ser Glu 
        755                 760                 765             


Pro Ser Glu Pro Leu Glu Leu Val Ile Lys Glu Met Tyr Pro Lys Pro 
    770                 775                 780                 


Phe Phe Lys Thr Trp Ala Ser Pro Val Val Thr Pro Gly Ala Arg Val 
785                 790                 795                 800 


Thr Phe Asn Cys Ser Thr Pro His Gln His Met Ser Phe Ile Leu Tyr 
                805                 810                 815     


Lys Asp Gly Ser Glu Ile Ala Ser Ser Asp Arg Ser Trp Ala Ser Pro 
            820                 825                 830         


Gly Ala Ser Ala Ala His Phe Leu Ile Ile Ser Val Gly Ile Gly Asp 
        835                 840                 845             


Gly Gly Asn Tyr Ser Cys Arg Tyr Tyr Asp Phe Ser Ile Trp Ser Glu 
    850                 855                 860                 


Pro Ser Asp Pro Val Glu Leu Val Val Thr Glu Phe Tyr Pro Lys Pro 
865                 870                 875                 880 


Thr Leu Leu Ala Gln Pro Gly Pro Val Val Phe Pro Gly Lys Ser Val 
                885                 890                 895     


Ile Leu Arg Cys Gln Gly Thr Phe Gln Gly Met Arg Phe Ala Leu Leu 
            900                 905                 910         


Gln Glu Gly Ala His Val Pro Leu Gln Phe Arg Ser Val Ser Gly Asn 
        915                 920                 925             


Ser Ala Asp Phe Leu Leu His Thr Val Gly Ala Glu Asp Ser Gly Asn 
    930                 935                 940                 


Tyr Ser Cys Ile Tyr Tyr Glu Thr Thr Met Ser Asn Arg Gly Ser Tyr 
945                 950                 955                 960 


Leu Ser Met Pro Leu Met Ile Trp Val Thr Asp Thr Phe Pro Lys Pro 
                965                 970                 975     


Trp Leu Phe Ala Glu Pro Ser Ser Val Val Pro Met Gly Gln Asn Val 
            980                 985                 990         


Thr Leu Trp Cys Arg Gly Pro Val  His Gly Val Gly Tyr  Ile Leu His 
        995                 1000                 1005             


Lys Glu  Gly Glu Ala Thr Ser  Met Gln Leu Trp Gly  Ser Thr Ser 
    1010                 1015                 1020             


Asn Asp  Gly Ala Phe Pro Ile  Thr Asn Ile Ser Gly  Thr Ser Met 
    1025                 1030                 1035             


Gly Arg  Tyr Ser Cys Cys Tyr  His Pro Asp Trp Thr  Ser Ser Ile 
    1040                 1045                 1050             


Lys Ile  Gln Pro Ser Asn Thr  Leu Glu Leu Leu Val  Thr Gly Leu 
    1055                 1060                 1065             


Leu Pro  Lys Pro Ser Leu Leu  Ala Gln Pro Gly Pro  Met Val Ala 
    1070                 1075                 1080             


Pro Gly  Glu Asn Met Thr Leu  Gln Cys Gln Gly Glu  Leu Pro Asp 
    1085                 1090                 1095             


Ser Thr  Phe Val Leu Leu Lys  Glu Gly Ala Gln Glu  Pro Leu Glu 
    1100                 1105                 1110             


Gln Gln  Arg Pro Ser Gly Tyr  Arg Ala Asp Phe Trp  Met Pro Ala 
    1115                 1120                 1125             


Val Arg  Gly Glu Asp Ser Gly  Ile Tyr Ser Cys Val  Tyr Tyr Leu 
    1130                 1135                 1140             


Asp Ser  Thr Pro Phe Ala Ala  Ser Asn His Ser Asp  Ser Leu Glu 
    1145                 1150                 1155             


Ile Trp  Val Thr Asp Lys Pro  Pro Lys Pro Ser Leu  Ser Ala Trp 
    1160                 1165                 1170             


Pro Ser  Thr Met Phe Lys Leu  Gly Lys Asp Ile Thr  Leu Gln Cys 
    1175                 1180                 1185             


Arg Gly  Pro Leu Pro Gly Val  Glu Phe Val Leu Glu  His Asp Gly 
    1190                 1195                 1200             


Glu Glu  Ala Pro Gln Gln Phe  Ser Glu Asp Gly Asp  Phe Val Ile 
    1205                 1210                 1215             


Asn Asn  Val Glu Gly Lys Gly  Ile Gly Asn Tyr Ser  Cys Ser Tyr 
    1220                 1225                 1230             


Arg Leu  Gln Ala Tyr Pro Asp  Ile Trp Ser Glu Pro  Ser Asp Pro 
    1235                 1240                 1245             


Leu Glu  Leu Val Gly Ala Ala  Gly Pro Val Ala Gln  Glu Cys Thr 
    1250                 1255                 1260             


Val Gly  Asn Ile Val Arg Ser  Ser Leu Ile Val Val  Val Val Val 
    1265                 1270                 1275             


Ala Leu  Gly Val Val Leu Ala  Ile Glu Trp Lys Lys  Trp Pro Arg 
    1280                 1285                 1290             


Leu Arg  Thr Arg Gly Ser Glu  Thr Asp Gly Arg Asp  Gln Thr Ile 
    1295                 1300                 1305             


Ala Leu  Glu Glu Cys Asn Gln  Glu Gly Glu Pro Gly  Thr Pro Ala 
    1310                 1315                 1320             


Asn Ser  Pro Ser Ser Thr Ser  Gln Arg Ile Ser Val  Glu Leu Pro 
    1325                 1330                 1335             


Val Pro  Ile 
    1340     


<210>  2261
<211>  1327
<212>  PRT
<213>  Homo sapiens

<400>  2261

Met Thr Leu Asp Arg Pro Gly Glu Gly Ala Thr Met Leu Lys Thr Phe 
1               5                   10                  15      


Thr Val Leu Leu Phe Cys Ile Leu Met Asp Pro Gln Pro Glu Leu Trp 
            20                  25                  30          


Ile Glu Ser Asn Tyr Pro Gln Ala Pro Trp Glu Asn Ile Thr Leu Trp 
        35                  40                  45              


Cys Arg Ser Pro Ser Arg Ile Ser Ser Lys Phe Leu Leu Leu Lys Asp 
    50                  55                  60                  


Lys Thr Gln Met Thr Trp Ile Arg Pro Ser His Lys Thr Phe Gln Val 
65                  70                  75                  80  


Ser Phe Leu Ile Gly Ala Leu Thr Glu Ser Asn Ala Gly Leu Tyr Arg 
                85                  90                  95      


Cys Cys Tyr Trp Lys Glu Thr Gly Trp Ser Lys Pro Ser Lys Val Leu 
            100                 105                 110         


Glu Leu Glu Ala Pro Gly Gln Leu Pro Lys Pro Ile Phe Trp Ile Gln 
        115                 120                 125             


Ala Glu Thr Pro Ala Leu Pro Gly Cys Asn Val Asn Ile Leu Cys His 
    130                 135                 140                 


Gly Trp Leu Gln Asp Leu Val Phe Met Leu Phe Lys Glu Gly Tyr Ala 
145                 150                 155                 160 


Glu Pro Val Asp Tyr Gln Val Pro Thr Gly Thr Met Ala Ile Phe Ser 
                165                 170                 175     


Ile Asp Asn Leu Thr Pro Glu Asp Glu Gly Val Tyr Ile Cys Arg Thr 
            180                 185                 190         


His Ile Gln Met Leu Pro Thr Leu Trp Ser Glu Pro Ser Asn Pro Leu 
        195                 200                 205             


Lys Leu Val Val Ala Gly Leu Tyr Pro Lys Pro Thr Leu Thr Ala His 
    210                 215                 220                 


Pro Gly Pro Ile Met Ala Pro Gly Glu Ser Leu Asn Leu Arg Cys Gln 
225                 230                 235                 240 


Gly Pro Ile Tyr Gly Met Thr Phe Ala Leu Met Arg Val Glu Asp Leu 
                245                 250                 255     


Glu Lys Ser Phe Tyr His Lys Lys Thr Ile Lys Asn Glu Ala Asn Phe 
            260                 265                 270         


Phe Phe Gln Ser Leu Lys Ile Gln Asp Thr Gly His Tyr Leu Cys Phe 
        275                 280                 285             


Tyr Tyr Asp Ala Ser Tyr Arg Gly Ser Leu Leu Ser Asp Val Leu Lys 
    290                 295                 300                 


Ile Trp Val Thr Asp Thr Phe Pro Lys Thr Trp Leu Leu Ala Arg Pro 
305                 310                 315                 320 


Ser Ala Val Val Gln Met Gly Gln Asn Val Ser Leu Arg Cys Arg Gly 
                325                 330                 335     


Pro Val Asp Gly Val Gly Leu Ala Leu Tyr Lys Lys Gly Glu Asp Lys 
            340                 345                 350         


Pro Leu Gln Phe Leu Asp Ala Thr Ser Ile Asp Asp Asn Thr Ser Phe 
        355                 360                 365             


Phe Leu Asn Asn Val Thr Tyr Ser Asp Thr Gly Ile Tyr Ser Cys His 
    370                 375                 380                 


Tyr Leu Leu Thr Trp Lys Thr Ser Ile Arg Met Pro Ser His Asn Thr 
385                 390                 395                 400 


Val Glu Leu Met Val Val Asp Lys Pro Pro Lys Pro Ser Leu Ser Ala 
                405                 410                 415     


Trp Pro Ser Thr Val Phe Lys Leu Gly Lys Ala Ile Thr Leu Gln Cys 
            420                 425                 430         


Arg Val Ser His Pro Val Leu Glu Phe Ser Leu Glu Trp Glu Glu Arg 
        435                 440                 445             


Glu Thr Phe Gln Lys Phe Ser Val Asn Gly Asp Phe Ile Ile Ser Asn 
    450                 455                 460                 


Val Asp Gly Lys Gly Thr Gly Thr Tyr Ser Cys Ser Tyr Arg Val Glu 
465                 470                 475                 480 


Thr His Pro Asn Ile Trp Ser His Arg Ser Glu Pro Leu Lys Leu Met 
                485                 490                 495     


Gly Pro Ala Gly Tyr Leu Thr Trp Asn Tyr Val Leu Asn Glu Ala Ile 
            500                 505                 510         


Arg Leu Ser Leu Ile Met Gln Leu Val Ala Leu Leu Leu Val Val Leu 
        515                 520                 525             


Trp Ile Arg Trp Lys Cys Arg Arg Leu Arg Ile Arg Glu Ala Trp Leu 
    530                 535                 540                 


Leu Gly Thr Ala Gln Gly Val Thr Met Leu Phe Ile Val Thr Ala Leu 
545                 550                 555                 560 


Leu Cys Cys Gly Leu Cys Asn Gly Val Leu Ile Glu Glu Thr Glu Ile 
                565                 570                 575     


Val Met Pro Thr Pro Lys Pro Glu Leu Trp Ala Glu Thr Asn Phe Pro 
            580                 585                 590         


Leu Ala Pro Trp Lys Asn Leu Thr Leu Trp Cys Arg Ser Pro Ser Gly 
        595                 600                 605             


Ser Thr Lys Glu Phe Val Leu Leu Lys Asp Gly Thr Gly Trp Ile Ala 
    610                 615                 620                 


Thr Arg Pro Ala Ser Glu Gln Val Arg Ala Ala Phe Pro Leu Gly Ala 
625                 630                 635                 640 


Leu Thr Gln Ser His Thr Gly Ser Tyr His Cys His Ser Trp Glu Glu 
                645                 650                 655     


Met Ala Val Ser Glu Pro Ser Glu Ala Leu Glu Leu Val Gly Thr Asp 
            660                 665                 670         


Ile Leu Pro Lys Pro Val Ile Ser Ala Ser Pro Thr Ile Arg Gly Gln 
        675                 680                 685             


Glu Leu Gln Leu Arg Cys Lys Gly Trp Leu Ala Gly Met Gly Phe Ala 
    690                 695                 700                 


Leu Tyr Lys Glu Gly Glu Gln Glu Pro Val Gln Gln Leu Gly Ala Val 
705                 710                 715                 720 


Gly Arg Glu Ala Phe Phe Thr Ile Gln Arg Met Glu Asp Lys Asp Glu 
                725                 730                 735     


Gly Asn Tyr Ser Cys Arg Thr His Thr Glu Lys Arg Pro Phe Lys Trp 
            740                 745                 750         


Ser Glu Pro Ser Glu Pro Leu Glu Leu Val Ile Lys Glu Met Tyr Pro 
        755                 760                 765             


Lys Pro Phe Phe Lys Thr Trp Ala Ser Pro Val Val Thr Pro Gly Ala 
    770                 775                 780                 


Arg Val Thr Phe Asn Cys Ser Thr Pro His Gln His Met Ser Phe Ile 
785                 790                 795                 800 


Leu Tyr Lys Asp Gly Ser Glu Ile Ala Ser Ser Asp Arg Ser Trp Ala 
                805                 810                 815     


Ser Pro Gly Ala Ser Ala Ala His Phe Leu Ile Ile Ser Val Gly Ile 
            820                 825                 830         


Gly Asp Gly Gly Asn Tyr Ser Cys Arg Tyr Tyr Asp Phe Ser Ile Trp 
        835                 840                 845             


Ser Glu Pro Ser Asp Pro Val Glu Leu Val Val Thr Glu Phe Tyr Pro 
    850                 855                 860                 


Lys Pro Thr Leu Leu Ala Gln Pro Gly Pro Val Val Phe Pro Gly Lys 
865                 870                 875                 880 


Ser Val Ile Leu Arg Cys Gln Gly Thr Phe Gln Gly Met Arg Phe Ala 
                885                 890                 895     


Leu Leu Gln Glu Gly Ala His Val Pro Leu Gln Phe Arg Ser Val Ser 
            900                 905                 910         


Gly Asn Ser Ala Asp Phe Leu Leu His Thr Val Gly Ala Glu Asp Ser 
        915                 920                 925             


Gly Asn Tyr Ser Cys Ile Tyr Tyr Glu Thr Thr Met Ser Asn Arg Gly 
    930                 935                 940                 


Ser Tyr Leu Ser Met Pro Leu Met Ile Trp Val Thr Asp Thr Phe Pro 
945                 950                 955                 960 


Lys Pro Trp Leu Phe Ala Glu Pro Ser Ser Val Val Pro Met Gly Gln 
                965                 970                 975     


Asn Val Thr Leu Trp Cys Arg Gly Pro Val His Gly Val Gly Tyr Ile 
            980                 985                 990         


Leu His Lys Glu Gly Glu Ala Thr  Ser Met Gln Leu Trp  Gly Ser Thr 
        995                 1000                 1005             


Ser Asn  Asp Gly Ala Phe Pro  Ile Thr Asn Ile Ser  Gly Thr Ser 
    1010                 1015                 1020             


Met Gly  Arg Tyr Ser Cys Cys  Tyr His Pro Asp Trp  Thr Ser Ser 
    1025                 1030                 1035             


Ile Lys  Ile Gln Pro Ser Asn  Thr Leu Glu Leu Leu  Val Thr Gly 
    1040                 1045                 1050             


Leu Leu  Pro Lys Pro Ser Leu  Leu Ala Gln Pro Gly  Pro Met Val 
    1055                 1060                 1065             


Ala Pro  Gly Glu Asn Met Thr  Leu Gln Cys Gln Gly  Glu Leu Pro 
    1070                 1075                 1080             


Asp Ser  Thr Phe Val Leu Leu  Lys Glu Gly Ala Gln  Glu Pro Leu 
    1085                 1090                 1095             


Glu Gln  Gln Arg Pro Ser Gly  Tyr Arg Ala Asp Phe  Trp Met Pro 
    1100                 1105                 1110             


Ala Val  Arg Gly Glu Asp Ser  Gly Ile Tyr Ser Cys  Val Tyr Tyr 
    1115                 1120                 1125             


Leu Asp  Ser Thr Pro Phe Ala  Ala Ser Asn His Ser  Asp Ser Leu 
    1130                 1135                 1140             


Glu Ile  Trp Val Thr Asp Lys  Pro Pro Lys Pro Ser  Leu Ser Ala 
    1145                 1150                 1155             


Trp Pro  Ser Thr Met Phe Lys  Leu Gly Lys Asp Ile  Thr Leu Gln 
    1160                 1165                 1170             


Cys Arg  Gly Pro Leu Pro Gly  Val Glu Phe Val Leu  Glu His Asp 
    1175                 1180                 1185             


Gly Glu  Glu Ala Pro Gln Gln  Phe Ser Glu Asp Gly  Asp Phe Val 
    1190                 1195                 1200             


Ile Asn  Asn Val Glu Gly Lys  Gly Ile Gly Asn Tyr  Ser Cys Ser 
    1205                 1210                 1215             


Tyr Arg  Leu Gln Ala Tyr Pro  Asp Ile Trp Ser Glu  Pro Ser Asp 
    1220                 1225                 1230             


Pro Leu  Glu Leu Val Gly Ala  Ala Gly Pro Val Ala  Gln Glu Cys 
    1235                 1240                 1245             


Thr Val  Gly Asn Ile Val Arg  Ser Ser Leu Ile Val  Val Val Val 
    1250                 1255                 1260             


Val Ala  Leu Gly Val Val Leu  Ala Ile Glu Trp Lys  Lys Trp Pro 
    1265                 1270                 1275             


Arg Leu  Arg Thr Arg Gly Ser  Glu Thr Asp Gly Arg  Asp Gln Thr 
    1280                 1285                 1290             


Ile Ala  Leu Glu Glu Cys Asn  Gln Glu Gly Glu Pro  Gly Thr Pro 
    1295                 1300                 1305             


Ala Asn  Ser Pro Ser Ser Thr  Ser Gln Arg Ile Ser  Val Glu Leu 
    1310                 1315                 1320             


Pro Val  Pro Ile 
    1325         


<210>  2262
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  2262

Met Thr Leu Asp Arg Pro Gly Glu Gly Ala Thr Met Leu Lys Thr Phe 
1               5                   10                  15      


Thr Val Leu Leu Phe Cys Ile Arg Met Ser Leu Gly Met Thr Ser Ile 
            20                  25                  30          


Val Met Asp Pro Gln Pro Glu Leu Trp Ile Glu Ser Asn Tyr Pro Gln 
        35                  40                  45              


Ala Pro Trp Glu Asn Ile Thr Leu Trp Cys Arg Ser Pro Ser Arg Ile 
    50                  55                  60                  


Ser Ser Lys Phe Leu Leu Leu Lys Asp Lys Thr Gln Met Thr Trp Ile 
65                  70                  75                  80  


Arg Pro Ser His Lys Thr Phe Gln Val Ser Phe Leu Ile Gly Ala Leu 
                85                  90                  95      


Thr Glu Ser Asn Ala Gly Leu Tyr Arg Cys Cys Tyr Trp Lys Glu Thr 
            100                 105                 110         


Gly Trp Ser Lys Pro Ser Lys Val Leu Glu Leu Glu Ala Pro Gly Gln 
        115                 120                 125             


Leu Pro Lys Pro Ile Phe Trp Ile Gln Ala Glu Thr Pro Ala Leu Pro 
    130                 135                 140                 


Gly Cys Asn Val Asn Ile Leu Cys His Gly Trp Leu Gln Asp Leu Val 
145                 150                 155                 160 


Phe Met Leu Phe Lys Glu Gly Tyr Ala Glu Pro Val Asp Tyr Gln Val 
                165                 170                 175     


Pro Thr Gly Thr Met Ala Ile Phe Ser Ile Asp Asn Leu Thr Pro Glu 
            180                 185                 190         


Asp Glu Gly Val Tyr Ile Cys Arg Thr His Ile Gln Met Leu Pro Thr 
        195                 200                 205             


Leu Trp Ser Glu Pro Ser Asn Pro Leu Lys Leu Val Val Ala Gly Gly 
    210                 215                 220                 


Cys Gly Tyr Gly Cys Trp His Leu Ala Ile Val Val Pro Gly Ile Met 
225                 230                 235                 240 


Ala Gly 
        


<210>  2263
<211>  1505
<212>  PRT
<213>  Homo sapiens

<400>  2263

Met Val His Val Ala Arg Leu Leu Leu Leu Leu Leu Thr Phe Phe Leu 
1               5                   10                  15      


Arg Thr Asp Ala Glu Thr Pro Pro Arg Phe Thr Arg Thr Pro Val Asp 
            20                  25                  30          


Gln Thr Gly Val Ser Gly Gly Val Ala Ser Phe Ile Cys Gln Ala Thr 
        35                  40                  45              


Gly Asp Pro Arg Pro Lys Ile Val Trp Asn Lys Lys Gly Lys Lys Val 
    50                  55                  60                  


Ser Asn Gln Arg Phe Glu Val Ile Glu Phe Asp Asp Gly Ser Gly Ser 
65                  70                  75                  80  


Val Leu Arg Ile Gln Pro Leu Arg Thr Pro Arg Asp Glu Ala Ile Tyr 
                85                  90                  95      


Glu Cys Val Ala Ser Asn Asn Val Gly Glu Ile Ser Val Ser Thr Arg 
            100                 105                 110         


Leu Thr Val Leu Arg Glu Asp Gln Ile Pro Arg Gly Phe Pro Thr Ile 
        115                 120                 125             


Asp Met Gly Pro Gln Leu Lys Val Val Glu Arg Thr Arg Thr Ala Thr 
    130                 135                 140                 


Met Leu Cys Ala Ala Ser Gly Asn Pro Asp Pro Glu Ile Thr Trp Phe 
145                 150                 155                 160 


Lys Asp Phe Leu Pro Val Asp Thr Ser Asn Asn Asn Gly Arg Ile Lys 
                165                 170                 175     


Gln Leu Arg Ser Glu Ser Ile Gly Ala Leu Gln Ile Glu Gln Ser Glu 
            180                 185                 190         


Glu Ser Asp Gln Gly Lys Tyr Glu Cys Val Ala Thr Asn Ser Ala Gly 
        195                 200                 205             


Thr Arg Tyr Ser Ala Pro Ala Asn Leu Tyr Val Arg Val Arg Arg Val 
    210                 215                 220                 


Pro Pro Arg Phe Ser Ile Pro Pro Thr Asn His Glu Ile Met Pro Gly 
225                 230                 235                 240 


Gly Ser Val Asn Ile Thr Cys Val Ala Val Gly Ser Pro Met Pro Tyr 
                245                 250                 255     


Val Lys Trp Met Leu Gly Ala Glu Asp Leu Thr Pro Glu Asp Asp Met 
            260                 265                 270         


Pro Ile Gly Arg Asn Val Leu Glu Leu Asn Asp Val Arg Gln Ser Ala 
        275                 280                 285             


Asn Tyr Thr Cys Val Ala Met Ser Thr Leu Gly Val Ile Glu Ala Ile 
    290                 295                 300                 


Ala Gln Ile Thr Val Lys Ala Leu Pro Lys Pro Pro Gly Thr Pro Val 
305                 310                 315                 320 


Val Thr Glu Ser Thr Ala Thr Ser Ile Thr Leu Thr Trp Asp Ser Gly 
                325                 330                 335     


Asn Pro Glu Pro Val Ser Tyr Tyr Ile Ile Gln His Lys Pro Lys Asn 
            340                 345                 350         


Ser Glu Glu Leu Tyr Lys Glu Ile Asp Gly Val Ala Thr Thr Arg Tyr 
        355                 360                 365             


Ser Val Ala Gly Leu Ser Pro Tyr Ser Asp Tyr Glu Phe Arg Val Val 
    370                 375                 380                 


Ala Val Asn Asn Ile Gly Arg Gly Pro Pro Ser Glu Pro Val Leu Thr 
385                 390                 395                 400 


Gln Thr Ser Glu Gln Ala Pro Ser Ser Ala Pro Arg Asp Val Gln Ala 
                405                 410                 415     


Arg Met Leu Ser Ser Thr Thr Ile Leu Val Gln Trp Lys Glu Pro Glu 
            420                 425                 430         


Glu Pro Asn Gly Gln Ile Gln Gly Tyr Arg Val Tyr Tyr Thr Met Asp 
        435                 440                 445             


Pro Thr Gln His Val Asn Asn Trp Met Lys His Asn Val Ala Asp Ser 
    450                 455                 460                 


Gln Ile Thr Thr Ile Gly Asn Leu Val Pro Gln Lys Thr Tyr Ser Val 
465                 470                 475                 480 


Lys Val Leu Ala Phe Thr Ser Ile Gly Asp Gly Pro Leu Ser Ser Asp 
                485                 490                 495     


Ile Gln Val Ile Thr Gln Thr Gly Val Pro Gly Gln Pro Leu Asn Phe 
            500                 505                 510         


Lys Ala Glu Pro Glu Ser Glu Thr Ser Ile Leu Leu Ser Trp Thr Pro 
        515                 520                 525             


Pro Arg Ser Asp Thr Ile Ala Asn Tyr Glu Leu Val Tyr Lys Asp Gly 
    530                 535                 540                 


Glu His Gly Glu Glu Gln Arg Ile Thr Ile Glu Pro Gly Thr Ser Tyr 
545                 550                 555                 560 


Arg Leu Gln Gly Leu Lys Pro Asn Ser Leu Tyr Tyr Phe Arg Leu Ala 
                565                 570                 575     


Ala Arg Ser Pro Gln Gly Leu Gly Ala Ser Thr Ala Glu Ile Ser Ala 
            580                 585                 590         


Arg Thr Met Gln Ser Met Phe Ala Lys Asn Phe His Val Lys Ala Val 
        595                 600                 605             


Met Lys Thr Ser Val Leu Leu Ser Trp Glu Ile Pro Glu Asn Tyr Asn 
    610                 615                 620                 


Ser Ala Met Pro Phe Lys Ile Leu Tyr Asp Asp Gly Lys Met Val Glu 
625                 630                 635                 640 


Glu Val Asp Gly Arg Ala Thr Gln Lys Leu Ile Val Asn Leu Lys Pro 
                645                 650                 655     


Glu Lys Ser Tyr Ser Phe Val Leu Thr Asn Arg Gly Asn Ser Ala Gly 
            660                 665                 670         


Gly Leu Gln His Arg Val Thr Ala Lys Thr Ala Pro Asp Val Leu Arg 
        675                 680                 685             


Thr Lys Pro Ala Phe Ile Gly Lys Thr Asn Leu Asp Gly Met Ile Thr 
    690                 695                 700                 


Val Gln Leu Pro Glu Val Pro Ala Asn Glu Asn Ile Lys Gly Tyr Tyr 
705                 710                 715                 720 


Ile Ile Ile Val Pro Leu Lys Lys Ser Arg Gly Lys Phe Ile Lys Pro 
                725                 730                 735     


Trp Glu Ser Pro Asp Glu Met Glu Leu Asp Glu Leu Leu Lys Glu Ile 
            740                 745                 750         


Ser Arg Lys Arg Arg Ser Ile Arg Tyr Gly Arg Glu Val Glu Leu Lys 
        755                 760                 765             


Pro Tyr Ile Ala Ala His Phe Asp Val Leu Pro Thr Glu Phe Thr Leu 
    770                 775                 780                 


Gly Asp Asp Lys His Tyr Gly Gly Phe Thr Asn Lys Gln Leu Gln Ser 
785                 790                 795                 800 


Gly Gln Glu Tyr Val Phe Phe Val Leu Ala Val Met Glu His Ala Glu 
                805                 810                 815     


Ser Lys Met Tyr Ala Thr Ser Pro Tyr Ser Asp Pro Val Val Ser Met 
            820                 825                 830         


Asp Leu Asp Pro Gln Pro Ile Thr Asp Glu Glu Glu Gly Leu Ile Trp 
        835                 840                 845             


Val Val Gly Pro Val Leu Ala Val Val Phe Ile Ile Cys Ile Val Ile 
    850                 855                 860                 


Ala Ile Leu Leu Tyr Lys Arg Lys Arg Ala Glu Ser Asp Ser Arg Lys 
865                 870                 875                 880 


Ser Ser Ile Pro Asn Asn Lys Glu Ile Pro Ser His His Pro Thr Asp 
                885                 890                 895     


Pro Val Glu Leu Arg Arg Leu Asn Phe Gln Thr Pro Gly Ser Asp Asp 
            900                 905                 910         


Ser Gly Tyr Pro Gly Asn Leu His Ser Ser Ser Met Ala Ser His Pro 
        915                 920                 925             


Pro Ile Pro Ile Leu Glu Leu Ala Asp His Ile Glu Arg Leu Lys Ala 
    930                 935                 940                 


Asn Asp Asn Leu Lys Phe Ser Gln Glu Tyr Glu Ser Ile Asp Pro Gly 
945                 950                 955                 960 


Gln Gln Phe Thr Trp Glu His Ser Asn Leu Glu Val Asn Lys Pro Lys 
                965                 970                 975     


Asn Arg Tyr Ala Asn Val Ile Ala Tyr Asp His Ser Arg Val Leu Leu 
            980                 985                 990         


Ser Ala Ile Glu Gly Ile Pro Gly  Ser Asp Tyr Val Asn  Ala Asn Tyr 
        995                 1000                 1005             


Ile Asp  Gly Tyr Arg Lys Gln  Asn Ala Tyr Ile Ala  Thr Gln Gly 
    1010                 1015                 1020             


Ser Leu  Pro Glu Thr Phe Gly  Asp Phe Trp Arg Met  Ile Trp Glu 
    1025                 1030                 1035             


Gln Arg  Ser Ala Thr Val Val  Met Met Thr Lys Leu  Glu Glu Arg 
    1040                 1045                 1050             


Ser Arg  Val Lys Cys Asp Gln  Tyr Trp Pro Ser Arg  Gly Thr Glu 
    1055                 1060                 1065             


Thr His  Gly Leu Val Gln Val  Thr Leu Leu Asp Thr  Val Glu Leu 
    1070                 1075                 1080             


Ala Thr  Tyr Cys Val Arg Thr  Phe Ala Leu Tyr Lys  Asn Gly Ser 
    1085                 1090                 1095             


Ser Glu  Lys Arg Glu Val Arg  Gln Phe Gln Phe Thr  Ala Trp Pro 
    1100                 1105                 1110             


Asp His  Gly Val Pro Glu His  Pro Thr Pro Phe Leu  Ala Phe Leu 
    1115                 1120                 1125             


Arg Arg  Val Lys Thr Cys Asn  Pro Pro Asp Ala Gly  Pro Met Val 
    1130                 1135                 1140             


Val His  Cys Ser Ala Gly Val  Gly Arg Thr Gly Cys  Phe Ile Val 
    1145                 1150                 1155             


Ile Asp  Ala Met Leu Glu Arg  Ile Lys His Glu Lys  Thr Val Asp 
    1160                 1165                 1170             


Ile Tyr  Gly His Val Thr Leu  Met Arg Ala Gln Arg  Asn Tyr Met 
    1175                 1180                 1185             


Val Gln  Thr Glu Asp Gln Tyr  Ile Phe Ile His Asp  Ala Leu Leu 
    1190                 1195                 1200             


Glu Ala  Val Thr Cys Gly Asn  Thr Glu Val Pro Ala  Arg Asn Leu 
    1205                 1210                 1215             


Tyr Ala  Tyr Ile Gln Lys Leu  Thr Gln Ile Glu Thr  Gly Glu Asn 
    1220                 1225                 1230             


Val Thr  Gly Met Glu Leu Glu  Phe Lys Arg Leu Ala  Ser Ser Lys 
    1235                 1240                 1245             


Ala His  Thr Ser Arg Phe Ile  Ser Ala Asn Leu Pro  Cys Asn Lys 
    1250                 1255                 1260             


Phe Lys  Asn Arg Leu Val Asn  Ile Met Pro Tyr Glu  Ser Thr Arg 
    1265                 1270                 1275             


Val Cys  Leu Gln Pro Ile Arg  Gly Val Glu Gly Ser  Asp Tyr Ile 
    1280                 1285                 1290             


Asn Ala  Ser Phe Ile Asp Gly  Tyr Arg Gln Gln Lys  Ala Tyr Ile 
    1295                 1300                 1305             


Ala Thr  Gln Gly Pro Leu Ala  Glu Thr Thr Glu Asp  Phe Trp Arg 
    1310                 1315                 1320             


Met Leu  Trp Glu His Asn Ser  Thr Ile Val Val Met  Leu Thr Lys 
    1325                 1330                 1335             


Leu Arg  Glu Met Gly Arg Glu  Lys Cys His Gln Tyr  Trp Pro Ala 
    1340                 1345                 1350             


Glu Arg  Ser Ala Arg Tyr Gln  Tyr Phe Val Val Asp  Pro Met Ala 
    1355                 1360                 1365             


Glu Tyr  Asn Met Pro Gln Tyr  Ile Leu Arg Glu Phe  Lys Val Thr 
    1370                 1375                 1380             


Asp Ala  Arg Asp Gly Gln Ser  Arg Thr Val Arg Gln  Phe Gln Phe 
    1385                 1390                 1395             


Thr Asp  Trp Pro Glu Gln Gly  Val Pro Lys Ser Gly  Glu Gly Phe 
    1400                 1405                 1410             


Ile Asp  Phe Ile Gly Gln Val  His Lys Thr Lys Glu  Gln Phe Gly 
    1415                 1420                 1425             


Gln Asp  Gly Pro Ile Ser Val  His Cys Ser Ala Gly  Val Gly Arg 
    1430                 1435                 1440             


Thr Gly  Val Phe Ile Thr Leu  Ser Ile Val Leu Glu  Arg Met Arg 
    1445                 1450                 1455             


Tyr Glu  Gly Val Val Asp Ile  Phe Gln Thr Val Lys  Met Leu Arg 
    1460                 1465                 1470             


Thr Gln  Arg Pro Ala Met Val  Gln Thr Glu Asp Gln  Tyr Gln Phe 
    1475                 1480                 1485             


Ser Tyr  Arg Ala Ala Leu Glu  Tyr Leu Gly Ser Phe  Asp His Tyr 
    1490                 1495                 1500             


Ala Thr  
    1505 


<210>  2264
<211>  881
<212>  PRT
<213>  Homo sapiens

<400>  2264

Met Ala Ala Ala Ala Ala Glu Glu Gly Met Glu Pro Arg Ala Leu Gln 
1               5                   10                  15      


Tyr Glu Gln Thr Leu Met Tyr Gly Arg Tyr Thr Gln Asp Leu Gly Ala 
            20                  25                  30          


Phe Ala Lys Glu Glu Ala Ala Arg Ile Arg Leu Gly Gly Pro Glu Pro 
        35                  40                  45              


Trp Lys Gly Pro Pro Ser Ser Arg Ala Ala Pro Glu Leu Leu Glu Tyr 
    50                  55                  60                  


Gly Arg Ser Arg Cys Ala Arg Cys Arg Val Cys Ser Val Arg Cys His 
65                  70                  75                  80  


Lys Phe Leu Val Ser Arg Val Gly Glu Asp Trp Ile Phe Leu Val Leu 
                85                  90                  95      


Leu Gly Leu Leu Met Ala Leu Val Ser Trp Val Met Asp Tyr Ala Ile 
            100                 105                 110         


Ala Ala Cys Leu Gln Ala Gln Gln Trp Met Ser Arg Gly Leu Asn Thr 
        115                 120                 125             


Ser Ile Leu Leu Gln Tyr Leu Ala Trp Val Thr Tyr Pro Val Val Leu 
    130                 135                 140                 


Ile Thr Phe Ser Ala Gly Phe Thr Gln Ile Leu Ala Pro Gln Ala Val 
145                 150                 155                 160 


Gly Ser Gly Ile Pro Glu Met Lys Thr Ile Leu Arg Gly Val Val Leu 
                165                 170                 175     


Lys Glu Tyr Leu Thr Leu Lys Thr Phe Ile Ala Lys Val Ile Gly Leu 
            180                 185                 190         


Thr Cys Ala Leu Gly Ser Gly Met Pro Leu Gly Lys Glu Gly Pro Phe 
        195                 200                 205             


Val His Ile Ala Ser Met Cys Ala Ala Leu Leu Ser Lys Phe Leu Ser 
    210                 215                 220                 


Leu Phe Gly Gly Ile Tyr Glu Asn Glu Ser Arg Asn Thr Glu Met Leu 
225                 230                 235                 240 


Ala Ala Ala Cys Ala Val Gly Val Gly Cys Cys Phe Ala Ala Pro Ile 
                245                 250                 255     


Gly Gly Val Leu Phe Ser Ile Glu Val Thr Ser Thr Phe Phe Ala Val 
            260                 265                 270         


Arg Asn Tyr Trp Arg Gly Phe Phe Ala Ala Thr Phe Ser Ala Phe Ile 
        275                 280                 285             


Phe Arg Val Leu Ala Val Trp Asn Arg Asp Glu Glu Thr Ile Thr Ala 
    290                 295                 300                 


Leu Phe Lys Thr Arg Phe Arg Leu Asp Phe Pro Phe Asp Leu Gln Glu 
305                 310                 315                 320 


Leu Pro Ala Phe Ala Val Ile Gly Ile Ala Ser Gly Phe Gly Gly Ala 
                325                 330                 335     


Leu Phe Val Tyr Leu Asn Arg Lys Ile Val Gln Val Met Arg Lys Gln 
            340                 345                 350         


Lys Thr Ile Asn Arg Phe Leu Met Arg Lys Arg Leu Leu Phe Pro Ala 
        355                 360                 365             


Leu Val Thr Leu Leu Ile Ser Thr Leu Thr Phe Pro Pro Gly Phe Gly 
    370                 375                 380                 


Gln Phe Met Ala Gly Gln Leu Ser Gln Lys Glu Thr Leu Val Thr Leu 
385                 390                 395                 400 


Phe Asp Asn Arg Thr Trp Val Arg Gln Gly Leu Val Glu Glu Leu Glu 
                405                 410                 415     


Pro Pro Ser Thr Ser Gln Ala Trp Asn Pro Pro Arg Ala Asn Val Phe 
            420                 425                 430         


Leu Thr Leu Val Ile Phe Ile Leu Met Lys Phe Trp Met Ser Ala Leu 
        435                 440                 445             


Ala Thr Thr Ile Pro Val Pro Cys Gly Ala Phe Met Pro Val Phe Val 
    450                 455                 460                 


Ile Asp Gly Ile His Thr Asp Ser Ser Thr Tyr Arg Ile Val Pro Gly 
465                 470                 475                 480 


Gly Tyr Ala Val Val Gly Ala Ala Ala Leu Ala Gly Ala Val Thr His 
                485                 490                 495     


Thr Val Ser Thr Ala Val Ile Val Phe Glu Leu Thr Gly Gln Ile Ala 
            500                 505                 510         


His Ile Leu Pro Val Met Ile Ala Val Ile Leu Ala Asn Ala Val Ala 
        515                 520                 525             


Gln Ser Leu Gln Pro Ser Leu Tyr Asp Ser Ile Ile Arg Ile Lys Lys 
    530                 535                 540                 


Leu Pro Tyr Leu Pro Glu Leu Gly Trp Gly Arg His Gln Gln Tyr Arg 
545                 550                 555                 560 


Val Arg Val Glu Asp Ile Met Val Arg Asp Val Pro His Val Ala Leu 
                565                 570                 575     


Ser Cys Thr Phe Arg Asp Leu Arg Leu Ala Leu His Arg Thr Lys Gly 
            580                 585                 590         


Arg Met Leu Ala Leu Val Glu Ser Pro Glu Ser Met Ile Leu Leu Gly 
        595                 600                 605             


Ser Ile Glu Arg Ser Gln Val Val Ala Leu Leu Gly Ala Gln Leu Ser 
    610                 615                 620                 


Pro Ala Arg Arg Arg Gln His Met Gln Glu Arg Arg Ala Thr Gln Thr 
625                 630                 635                 640 


Ser Pro Leu Ser Asp Gln Glu Gly Pro Pro Thr Pro Glu Ala Ser Val 
                645                 650                 655     


Cys Phe Gln Val Asn Thr Glu Asp Ser Ala Phe Pro Ala Ala Arg Gly 
            660                 665                 670         


Glu Thr His Lys Pro Leu Lys Pro Ala Leu Lys Arg Gly Pro Ser Val 
        675                 680                 685             


Thr Arg Asn Leu Gly Glu Ser Pro Thr Gly Ser Ala Glu Ser Ala Gly 
    690                 695                 700                 


Ile Ala Leu Arg Ser Leu Phe Cys Gly Ser Pro Pro Pro Glu Ala Ala 
705                 710                 715                 720 


Ser Glu Lys Leu Glu Ser Cys Glu Lys Arg Lys Leu Lys Arg Val Arg 
                725                 730                 735     


Ile Ser Leu Ala Ser Asp Ala Asp Leu Glu Gly Glu Met Ser Pro Glu 
            740                 745                 750         


Glu Ile Leu Glu Trp Glu Glu Gln Gln Leu Asp Glu Pro Val Asn Phe 
        755                 760                 765             


Ser Asp Cys Lys Ile Asp Pro Ala Pro Phe Gln Leu Val Glu Arg Thr 
    770                 775                 780                 


Ser Leu His Lys Thr His Thr Ile Phe Ser Leu Leu Gly Val Asp His 
785                 790                 795                 800 


Ala Tyr Val Thr Ser Ile Gly Arg Leu Ile Gly Ile Val Thr Leu Lys 
                805                 810                 815     


Glu Leu Arg Lys Ala Ile Glu Gly Ser Val Thr Ala Gln Gly Val Lys 
            820                 825                 830         


Val Arg Pro Pro Leu Ala Ser Phe Arg Asp Ser Ala Thr Ser Ser Ser 
        835                 840                 845             


Asp Thr Glu Thr Thr Glu Val His Ala Leu Trp Gly Pro His Ser Arg 
    850                 855                 860                 


His Gly Leu Pro Arg Glu Gly Ser Pro Ser Asp Ser Asp Asp Lys Cys 
865                 870                 875                 880 


Gln 
    


<210>  2265
<211>  854
<212>  PRT
<213>  Homo sapiens

<400>  2265

Met Ala Ala Ala Ala Ala Glu Glu Gly Met Glu Pro Arg Ala Leu Gln 
1               5                   10                  15      


Tyr Glu Gln Thr Leu Met Tyr Gly Arg Tyr Thr Gln Asp Leu Gly Ala 
            20                  25                  30          


Phe Ala Lys Glu Glu Ala Ala Arg Ile Arg Leu Gly Gly Pro Glu Pro 
        35                  40                  45              


Trp Lys Gly Pro Pro Ser Ser Arg Ala Ala Pro Glu Leu Leu Glu Tyr 
    50                  55                  60                  


Gly Arg Ser Arg Cys Ala Arg Cys Arg Ala Gln Gln Trp Met Ser Arg 
65                  70                  75                  80  


Gly Leu Asn Thr Ser Ile Leu Leu Gln Tyr Leu Ala Trp Val Thr Tyr 
                85                  90                  95      


Pro Val Val Leu Ile Thr Phe Ser Ala Gly Phe Thr Gln Ile Leu Ala 
            100                 105                 110         


Pro Gln Ala Val Gly Ser Gly Ile Pro Glu Met Lys Thr Ile Leu Arg 
        115                 120                 125             


Gly Val Val Leu Lys Glu Tyr Leu Thr Leu Lys Thr Phe Ile Ala Lys 
    130                 135                 140                 


Val Ile Gly Leu Thr Cys Ala Leu Gly Ser Gly Met Pro Leu Gly Lys 
145                 150                 155                 160 


Glu Gly Pro Phe Val His Ile Ala Ser Met Cys Ala Ala Leu Leu Ser 
                165                 170                 175     


Lys Phe Leu Ser Leu Phe Gly Gly Ile Tyr Glu Asn Glu Ser Arg Asn 
            180                 185                 190         


Thr Glu Met Leu Ala Ala Ala Cys Ala Val Gly Val Gly Cys Cys Phe 
        195                 200                 205             


Ala Ala Pro Ile Gly Gly Val Leu Phe Ser Ile Glu Val Thr Ser Thr 
    210                 215                 220                 


Phe Phe Ala Val Arg Asn Tyr Trp Arg Gly Phe Phe Ala Ala Thr Phe 
225                 230                 235                 240 


Ser Ala Phe Ile Phe Arg Val Leu Ala Val Trp Asn Arg Asp Glu Glu 
                245                 250                 255     


Thr Ile Thr Ala Leu Phe Lys Thr Arg Phe Arg Leu Asp Phe Pro Phe 
            260                 265                 270         


Asp Leu Gln Glu Leu Pro Ala Phe Ala Val Ile Gly Ile Ala Ser Gly 
        275                 280                 285             


Phe Gly Gly Ala Leu Phe Val Tyr Leu Asn Arg Lys Ile Val Gln Val 
    290                 295                 300                 


Met Arg Lys Gln Lys Thr Ile Asn Arg Phe Leu Met Arg Lys Arg Leu 
305                 310                 315                 320 


Leu Phe Pro Ala Leu Val Thr Leu Leu Ile Ser Thr Leu Thr Phe Pro 
                325                 330                 335     


Pro Gly Phe Gly Gln Phe Met Ala Gly Gln Leu Ser Gln Lys Glu Thr 
            340                 345                 350         


Leu Val Thr Leu Phe Asp Asn Arg Thr Trp Val Arg Gln Gly Leu Val 
        355                 360                 365             


Glu Glu Leu Glu Pro Pro Ser Thr Ser Gln Ala Trp Asn Pro Pro Arg 
    370                 375                 380                 


Ala Asn Val Phe Leu Thr Leu Val Ile Phe Ile Leu Met Lys Phe Trp 
385                 390                 395                 400 


Met Ser Ala Leu Ala Thr Thr Ile Pro Val Pro Cys Gly Ala Phe Met 
                405                 410                 415     


Pro Val Phe Val Ile Gly Ala Ala Phe Gly Arg Leu Val Gly Glu Ser 
            420                 425                 430         


Met Ala Ala Trp Phe Pro Asp Gly Ile His Thr Asp Ser Ser Thr Tyr 
        435                 440                 445             


Arg Ile Val Pro Gly Gly Tyr Ala Val Val Gly Ala Ala Ala Leu Ala 
    450                 455                 460                 


Gly Ala Val Thr His Thr Val Ser Thr Ala Val Ile Val Phe Glu Leu 
465                 470                 475                 480 


Thr Gly Gln Ile Ala His Ile Leu Pro Val Met Ile Ala Val Ile Leu 
                485                 490                 495     


Ala Asn Ala Val Ala Gln Ser Leu Gln Pro Ser Leu Tyr Asp Ser Ile 
            500                 505                 510         


Ile Arg Ile Lys Lys Leu Pro Tyr Leu Pro Glu Leu Gly Trp Gly Arg 
        515                 520                 525             


His Gln Gln Tyr Arg Val Arg Val Glu Asp Ile Met Val Arg Asp Val 
    530                 535                 540                 


Pro His Val Ala Leu Ser Cys Thr Phe Arg Asp Leu Arg Leu Ala Leu 
545                 550                 555                 560 


His Arg Thr Lys Gly Arg Met Leu Ala Leu Val Glu Ser Pro Glu Ser 
                565                 570                 575     


Met Ile Leu Leu Gly Ser Ile Glu Arg Ser Gln Val Val Ala Leu Leu 
            580                 585                 590         


Gly Ala Gln Leu Ser Pro Ala Arg Arg Arg Gln His Met Gln Glu Arg 
        595                 600                 605             


Arg Ala Thr Gln Thr Ser Pro Leu Ser Asp Gln Glu Gly Pro Pro Thr 
    610                 615                 620                 


Pro Glu Ala Ser Val Cys Phe Gln Val Asn Thr Glu Asp Ser Ala Phe 
625                 630                 635                 640 


Pro Ala Ala Arg Gly Glu Thr His Lys Pro Leu Lys Pro Ala Leu Lys 
                645                 650                 655     


Arg Gly Pro Ser Val Thr Arg Asn Leu Gly Glu Ser Pro Thr Gly Ser 
            660                 665                 670         


Ala Glu Ser Ala Gly Ile Ala Leu Arg Ser Leu Phe Cys Gly Ser Pro 
        675                 680                 685             


Pro Pro Glu Ala Ala Ser Glu Lys Leu Glu Ser Cys Glu Lys Arg Lys 
    690                 695                 700                 


Leu Lys Arg Val Arg Ile Ser Leu Ala Ser Asp Ala Asp Leu Glu Gly 
705                 710                 715                 720 


Glu Met Ser Pro Glu Glu Ile Leu Glu Trp Glu Glu Gln Gln Leu Asp 
                725                 730                 735     


Glu Pro Val Asn Phe Ser Asp Cys Lys Ile Asp Pro Ala Pro Phe Gln 
            740                 745                 750         


Leu Val Glu Arg Thr Ser Leu His Lys Thr His Thr Ile Phe Ser Leu 
        755                 760                 765             


Leu Gly Val Asp His Ala Tyr Val Thr Ser Ile Gly Arg Leu Ile Gly 
    770                 775                 780                 


Ile Val Thr Leu Lys Glu Leu Arg Lys Ala Ile Glu Gly Ser Val Thr 
785                 790                 795                 800 


Ala Gln Gly Val Lys Val Arg Pro Pro Leu Ala Ser Phe Arg Asp Ser 
                805                 810                 815     


Ala Thr Ser Ser Ser Asp Thr Glu Thr Thr Glu Val His Ala Leu Trp 
            820                 825                 830         


Gly Pro His Ser Arg His Gly Leu Pro Arg Glu Gly Ser Pro Ser Asp 
        835                 840                 845             


Ser Asp Asp Lys Cys Gln 
    850                 


<210>  2266
<211>  869
<212>  PRT
<213>  Homo sapiens

<400>  2266

Met Ala Ala Ala Ala Ala Glu Glu Gly Met Glu Pro Arg Ala Leu Gln 
1               5                   10                  15      


Tyr Glu Gln Thr Leu Met Tyr Gly Arg Tyr Thr Gln Asp Leu Gly Ala 
            20                  25                  30          


Phe Ala Lys Glu Glu Ala Ala Arg Ile Arg Leu Gly Gly Pro Glu Pro 
        35                  40                  45              


Trp Lys Gly Pro Pro Ser Ser Arg Ala Ala Pro Glu Leu Leu Glu Tyr 
    50                  55                  60                  


Gly Arg Ser Arg Cys Ala Arg Cys Arg Val Cys Ser Val Arg Cys His 
65                  70                  75                  80  


Lys Phe Leu Val Ser Arg Val Gly Glu Asp Trp Ile Phe Leu Val Leu 
                85                  90                  95      


Leu Gly Leu Leu Met Ala Leu Val Ser Trp Val Met Asp Tyr Ala Ile 
            100                 105                 110         


Ala Ala Cys Leu Gln Ala Gln Gln Trp Met Ser Arg Gly Leu Asn Thr 
        115                 120                 125             


Ser Ile Leu Leu Gln Tyr Leu Ala Trp Val Thr Tyr Pro Val Val Leu 
    130                 135                 140                 


Ile Thr Phe Ser Ala Gly Phe Thr Gln Ile Leu Ala Pro Gln Ala Val 
145                 150                 155                 160 


Gly Ser Gly Ile Pro Glu Met Lys Thr Ile Leu Arg Gly Val Val Leu 
                165                 170                 175     


Lys Glu Tyr Leu Thr Leu Lys Thr Phe Ile Ala Lys Val Ile Gly Leu 
            180                 185                 190         


Thr Cys Ala Leu Gly Ser Gly Met Pro Leu Gly Lys Glu Gly Pro Phe 
        195                 200                 205             


Val His Ile Ala Ser Met Cys Ala Ala Leu Leu Ser Lys Phe Leu Ser 
    210                 215                 220                 


Leu Phe Gly Gly Ile Tyr Glu Asn Glu Ser Arg Asn Thr Glu Met Leu 
225                 230                 235                 240 


Ala Ala Ala Cys Ala Val Gly Val Gly Cys Cys Phe Ala Ala Pro Ile 
                245                 250                 255     


Gly Gly Val Leu Phe Ser Ile Glu Val Thr Ser Thr Phe Phe Ala Val 
            260                 265                 270         


Arg Asn Tyr Trp Arg Gly Phe Phe Ala Ala Thr Phe Ser Ala Phe Ile 
        275                 280                 285             


Phe Arg Val Leu Ala Val Trp Asn Arg Asp Glu Glu Thr Ile Thr Ala 
    290                 295                 300                 


Leu Phe Lys Thr Arg Phe Arg Leu Asp Phe Pro Phe Asp Leu Gln Glu 
305                 310                 315                 320 


Leu Pro Ala Phe Ala Val Ile Gly Ile Ala Ser Gly Phe Gly Gly Ala 
                325                 330                 335     


Leu Phe Val Tyr Leu Asn Arg Lys Ile Val Gln Val Met Arg Lys Gln 
            340                 345                 350         


Lys Thr Ile Asn Arg Phe Leu Met Arg Lys Arg Leu Leu Phe Pro Ala 
        355                 360                 365             


Leu Val Thr Leu Leu Ile Ser Thr Leu Thr Phe Pro Pro Gly Phe Gly 
    370                 375                 380                 


Gln Phe Met Ala Gly Gln Leu Ser Gln Lys Glu Thr Leu Val Thr Leu 
385                 390                 395                 400 


Phe Asp Asn Arg Thr Trp Val Arg Gln Gly Leu Val Glu Glu Leu Glu 
                405                 410                 415     


Pro Pro Ser Thr Ser Gln Ala Trp Asn Pro Pro Arg Ala Asn Val Phe 
            420                 425                 430         


Leu Thr Leu Val Ile Phe Ile Leu Met Lys Phe Trp Met Ser Ala Leu 
        435                 440                 445             


Ala Thr Thr Ile Pro Val Pro Cys Gly Ala Phe Met Pro Val Phe Val 
    450                 455                 460                 


Ile Gly Ala Ala Phe Gly Arg Leu Val Gly Glu Ser Met Ala Ala Trp 
465                 470                 475                 480 


Phe Pro Asp Gly Ile His Thr Asp Ser Ser Thr Tyr Arg Ile Val Pro 
                485                 490                 495     


Gly Gly Tyr Ala Val Val Gly Ala Ala Ala Leu Ala Gly Ala Val Thr 
            500                 505                 510         


His Thr Val Ser Thr Ala Val Ile Val Phe Glu Leu Thr Gly Gln Ile 
        515                 520                 525             


Ala His Ile Leu Pro Val Met Ile Ala Val Ile Leu Ala Asn Ala Val 
    530                 535                 540                 


Ala Gln Ser Leu Gln Pro Ser Leu Tyr Asp Ser Ile Ile Arg Ile Lys 
545                 550                 555                 560 


Lys Leu Pro Tyr Leu Pro Glu Leu Gly Trp Gly Arg His Gln Gln Tyr 
                565                 570                 575     


Arg Val Arg Val Glu Asp Ile Met Val Arg Asp Val Pro His Val Ala 
            580                 585                 590         


Leu Ser Cys Thr Phe Arg Asp Leu Arg Leu Ala Leu His Arg Thr Lys 
        595                 600                 605             


Gly Arg Met Leu Ala Leu Val Glu Ser Pro Glu Ser Met Ile Leu Leu 
    610                 615                 620                 


Gly Ser Ile Glu Arg Ser Gln Val Val Ala Leu Leu Gly Ala Gln Leu 
625                 630                 635                 640 


Ser Pro Ala Arg Arg Arg Gln His Met Gln Glu Arg Arg Ala Thr Gln 
                645                 650                 655     


Thr Ser Pro Leu Ser Asp Gln Glu Gly Pro Pro Thr Pro Glu Ala Ser 
            660                 665                 670         


Val Cys Phe Gln Val Asn Thr Glu Asp Ser Ala Phe Pro Ala Ala Arg 
        675                 680                 685             


Gly Glu Thr His Lys Pro Leu Lys Pro Ala Leu Lys Arg Gly Pro Ser 
    690                 695                 700                 


Val Thr Arg Asn Leu Gly Glu Ser Pro Thr Gly Ser Ala Glu Ser Ala 
705                 710                 715                 720 


Gly Ile Ala Leu Arg Ser Leu Phe Cys Gly Ser Pro Pro Pro Glu Ala 
                725                 730                 735     


Ala Ser Glu Lys Leu Glu Ser Cys Glu Lys Arg Lys Leu Lys Arg Val 
            740                 745                 750         


Arg Ile Ser Leu Ala Ser Asp Ala Asp Leu Glu Gly Glu Met Ser Pro 
        755                 760                 765             


Glu Glu Ile Leu Glu Trp Glu Glu Gln Gln Leu Asp Glu Pro Val Asn 
    770                 775                 780                 


Phe Ser Asp Cys Lys Ile Asp Pro Ala Pro Phe Gln Leu Val Glu Arg 
785                 790                 795                 800 


Thr Ser Leu His Lys Leu Arg Lys Ala Ile Glu Gly Ser Val Thr Ala 
                805                 810                 815     


Gln Gly Val Lys Val Arg Pro Pro Leu Ala Ser Phe Arg Asp Ser Ala 
            820                 825                 830         


Thr Ser Ser Ser Asp Thr Glu Thr Thr Glu Val His Ala Leu Trp Gly 
        835                 840                 845             


Pro His Ser Arg His Gly Leu Pro Arg Glu Gly Ser Pro Ser Asp Ser 
    850                 855                 860                 


Asp Asp Lys Cys Gln 
865                 


<210>  2267
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  2267

Met Ala Ser Leu Gly Leu Gln Leu Val Gly Tyr Ile Leu Gly Leu Leu 
1               5                   10                  15      


Gly Leu Leu Gly Thr Leu Val Ala Met Leu Leu Pro Ser Trp Lys Thr 
            20                  25                  30          


Ser Ser Tyr Val Gly Ala Ser Ile Val Thr Ala Val Gly Phe Ser Lys 
        35                  40                  45              


Gly Leu Trp Met Glu Cys Ala Thr His Ser Thr Gly Ile Thr Gln Cys 
    50                  55                  60                  


Asp Ile Tyr Ser Thr Leu Leu Gly Leu Pro Ala Asp Ile Gln Ala Ala 
65                  70                  75                  80  


Gln Ala Met Met Val Thr Ser Ser Ala Ile Ser Ser Leu Ala Cys Ile 
                85                  90                  95      


Ile Ser Val Val Gly Met Arg Cys Thr Val Phe Cys Gln Glu Ser Arg 
            100                 105                 110         


Ala Lys Asp Arg Val Ala Val Ala Gly Gly Val Phe Phe Ile Leu Gly 
        115                 120                 125             


Gly Leu Leu Gly Phe Ile Pro Val Ala Trp Asn Leu His Gly Ile Leu 
    130                 135                 140                 


Arg Asp Phe Tyr Ser Pro Leu Val Pro Asp Ser Met Lys Phe Glu Ile 
145                 150                 155                 160 


Gly Glu Ala Leu Tyr Leu Gly Ile Ile Ser Ser Leu Phe Ser Leu Ile 
                165                 170                 175     


Ala Gly Ile Ile Leu Cys Phe Ser Cys Ser Ser Gln Arg Asn Arg Ser 
            180                 185                 190         


Asn Tyr Tyr Asp Ala Tyr Gln Ala Gln Pro Leu Ala Thr Arg Ser Ser 
        195                 200                 205             


Pro Arg Pro Gly Gln Pro Pro Lys Val Lys Ser Glu Phe Asn Ser Tyr 
    210                 215                 220                 


Ser Leu Thr Gly Tyr Val 
225                 230 


<210>  2268
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  2268

Met Ala Ser Leu Gly Leu Gln Leu Val Gly Tyr Ile Leu Gly Leu Leu 
1               5                   10                  15      


Gly Leu Leu Gly Thr Leu Val Ala Met Leu Leu Pro Ser Trp Lys Thr 
            20                  25                  30          


Ser Ser Tyr Val Gly Ala Ser Ile Val Thr Ala Val Gly Phe Ser Lys 
        35                  40                  45              


Gly Leu Trp Met Glu Cys Ala Thr His Ser Thr Gly Ile Thr Gln Cys 
    50                  55                  60                  


Asp Ile Tyr Ser Thr Leu Leu Gly Leu Pro Ala Asp Ile Gln Ala Ala 
65                  70                  75                  80  


Gln Ala Met Met Val Thr Ser Ser Ala Ile Ser Ser Leu Ala Cys Ile 
                85                  90                  95      


Ile Ser Val Val Gly Met Arg Cys Thr Val Phe Cys Gln Glu Ser Arg 
            100                 105                 110         


Ala Lys Asp Arg Val Ala Val Ala Gly Gly Val Phe Phe Ile Leu Gly 
        115                 120                 125             


Gly Leu Leu Gly Phe Ile Pro Val Ala Trp Asn Leu His Gly Ile Leu 
    130                 135                 140                 


Arg Asp Phe Tyr Ser Pro Leu Val Pro Asp Ser Met Lys Phe Glu Ile 
145                 150                 155                 160 


Gly Glu Ala Leu Tyr Leu Gly Ile Ile Ser Ser Leu Phe Ser Leu Ile 
                165                 170                 175     


Ala Gly Ile Ile Leu Cys Phe Ser Cys Ser Ser Gln Arg Asn Arg Ser 
            180                 185                 190         


Asn Tyr Tyr Asp Ala Tyr Gln Ala Gln Pro Leu Ala Thr Arg Ser Ser 
        195                 200                 205             


Pro Arg Pro Gly Gln Pro Pro Lys Val Lys Ser Glu Phe Asn Ser Tyr 
    210                 215                 220                 


Ser Leu Thr Gly Tyr Val 
225                 230 


<210>  2269
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  2269

Met Arg Leu Ala Gly Pro Leu Arg Ile Val Val Leu Val Val Ser Val 
1               5                   10                  15      


Gly Val Thr Trp Ile Val Val Ser Ile Leu Leu Gly Gly Pro Gly Ser 
            20                  25                  30          


Gly Phe Pro Arg Ile Gln Gln Leu Phe Thr Ser Pro Glu Ser Ser Val 
        35                  40                  45              


Thr Ala Ala Pro Arg Ala Arg Lys Tyr Lys Cys Gly Leu Pro Gln Pro 
    50                  55                  60                  


Cys Pro Glu Glu His Leu Ala Phe Arg Val Val Ser Gly Ala Ala Asn 
65                  70                  75                  80  


Val Ile Gly Pro Lys Ile Cys Leu Glu Asp Lys Met Leu Met Ser Ser 
                85                  90                  95      


Val Lys Asp Asn Val Gly Arg Gly Leu Asn Ile Ala Leu Val Asn Gly 
            100                 105                 110         


Val Ser Gly Glu Leu Ile Glu Ala Arg Ala Phe Asp Met Trp Ala Gly 
        115                 120                 125             


Asp Val Asn Asp Leu Leu Lys Phe Ile Arg Pro Leu His Glu Gly Thr 
    130                 135                 140                 


Leu Val Phe Val Ala Ser Tyr Asp Asp Pro Ala Thr Lys Met Asn Glu 
145                 150                 155                 160 


Glu Thr Arg Lys Leu Phe Ser Glu Leu Gly Ser Arg Asn Ala Lys Glu 
                165                 170                 175     


Leu Ala Phe Arg Asp Ser Trp Val Phe Val Gly Ala Lys Gly Val Gln 
            180                 185                 190         


Asn Lys Ser Pro Phe Glu Gln His Val Lys Asn Ser Lys His Ser Asn 
        195                 200                 205             


Lys Tyr Glu Gly Trp Pro Glu Ala Leu Glu Met Glu Gly Cys Ile Pro 
    210                 215                 220                 


Arg Arg Ser Thr Ala Ser 
225                 230 


<210>  2270
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  2270

Met Arg Leu Ala Gly Pro Glu Ser Ser Val Thr Ala Ala Pro Arg Ala 
1               5                   10                  15      


Arg Lys Tyr Lys Cys Gly Leu Pro Gln Pro Cys Pro Glu Glu His Leu 
            20                  25                  30          


Ala Phe Arg Val Val Ser Gly Ala Ala Asn Val Ile Gly Pro Lys Ile 
        35                  40                  45              


Cys Leu Glu Asp Lys Met Leu Met Ser Ser Val Lys Asp Asn Val Gly 
    50                  55                  60                  


Arg Gly Leu Asn Ile Ala Leu Val Asn Gly Val Ser Gly Glu Leu Ile 
65                  70                  75                  80  


Glu Ala Arg Ala Phe Asp Met Trp Ala Gly Asp Val Asn Asp Leu Leu 
                85                  90                  95      


Lys Phe Ile Arg Pro Leu His Glu Gly Thr Leu Val Phe Val Ala Ser 
            100                 105                 110         


Tyr Asp Asp Pro Ala Thr Lys Met Asn Glu Glu Thr Arg Lys Leu Phe 
        115                 120                 125             


Ser Glu Leu Gly Ser Arg Asn Ala Lys Glu Leu Ala Phe Arg Asp Ser 
    130                 135                 140                 


Trp Val Phe Val Gly Ala Lys Gly Val Gln Asn Lys Ser Pro Phe Glu 
145                 150                 155                 160 


Gln His Val Lys Asn Ser Lys His Ser Asn Lys Tyr Glu Gly Trp Pro 
                165                 170                 175     


Glu Ala Leu Glu Met Glu Gly Cys Ile Pro Arg Arg Ser Thr Ala Ser 
            180                 185                 190         


<210>  2271
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  2271

Met Arg Leu Ala Gly Pro Leu Arg Ile Val Val Leu Val Val Ser Val 
1               5                   10                  15      


Gly Val Thr Trp Ile Val Val Ser Ile Leu Leu Gly Gly Pro Gly Ser 
            20                  25                  30          


Gly Phe Pro Arg Ile Gln Gln Leu Phe Thr Ser Pro Glu Ser Ser Val 
        35                  40                  45              


Thr Ala Ala Pro Arg Ala Arg Lys Tyr Lys Cys Gly Leu Pro Gln Pro 
    50                  55                  60                  


Cys Pro Glu Glu His Leu Ala Phe Arg Val Val Ser Gly Ala Ala Asn 
65                  70                  75                  80  


Val Ile Gly Pro Lys Ile Cys Leu Glu Asp Lys Met Leu Met Ser Ser 
                85                  90                  95      


Val Lys Asp Asn Val Gly Arg Gly Leu Asn Ile Ala Leu Val Asn Asp 
            100                 105                 110         


Val Asn Asp Leu Leu Lys Phe Ile Arg Pro Leu His Glu Gly Thr Leu 
        115                 120                 125             


Val Phe Val Ala Ser Tyr Asp Asp Pro Ala Thr Lys Met Asn Glu Glu 
    130                 135                 140                 


Thr Arg Lys Leu Phe Ser Glu Leu Gly Ser Arg Asn Ala Lys Glu Leu 
145                 150                 155                 160 


Ala Phe Arg Asp Ser Trp Val Phe Val Gly Ala Lys Gly Val Gln Asn 
                165                 170                 175     


Lys Ser Pro Phe Glu Gln His Val Lys Asn Ser Lys His Ser Asn Lys 
            180                 185                 190         


Tyr Glu Gly Trp Pro Glu Ala Leu Glu Met Glu Gly Cys Ile Pro Arg 
        195                 200                 205             


Arg Ser Thr Ala Ser 
    210             


<210>  2272
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  2272

Met Asp Gln Phe Pro Glu Ser Val Thr Glu Asn Phe Glu Tyr Asp Asp 
1               5                   10                  15      


Leu Ala Glu Ala Cys Tyr Ile Gly Asp Ile Val Val Phe Gly Thr Val 
            20                  25                  30          


Phe Leu Ser Ile Phe Tyr Ser Val Ile Phe Ala Ile Gly Leu Val Gly 
        35                  40                  45              


Asn Leu Leu Val Val Phe Ala Leu Thr Asn Ser Lys Lys Pro Lys Ser 
    50                  55                  60                  


Val Thr Asp Ile Tyr Leu Leu Asn Leu Ala Leu Ser Asp Leu Leu Phe 
65                  70                  75                  80  


Val Ala Thr Leu Pro Phe Trp Thr His Tyr Leu Ile Asn Glu Lys Gly 
                85                  90                  95      


Leu His Asn Ala Met Cys Lys Phe Thr Thr Ala Phe Phe Phe Ile Gly 
            100                 105                 110         


Phe Phe Gly Ser Ile Phe Phe Ile Thr Val Ile Ser Ile Asp Arg Tyr 
        115                 120                 125             


Leu Ala Ile Val Leu Ala Ala Asn Ser Met Asn Asn Arg Thr Val Gln 
    130                 135                 140                 


His Gly Val Thr Ile Ser Leu Gly Val Trp Ala Ala Ala Ile Leu Val 
145                 150                 155                 160 


Ala Ala Pro Gln Phe Met Phe Thr Lys Gln Lys Glu Asn Glu Cys Leu 
                165                 170                 175     


Gly Asp Tyr Pro Glu Val Leu Gln Glu Ile Trp Pro Val Leu Arg Asn 
            180                 185                 190         


Val Glu Thr Asn Phe Leu Gly Phe Leu Leu Pro Leu Leu Ile Met Ser 
        195                 200                 205             


Tyr Cys Tyr Phe Arg Ile Ile Gln Thr Leu Phe Ser Cys Lys Asn His 
    210                 215                 220                 


Lys Lys Ala Lys Ala Ile Lys Leu Ile Leu Leu Val Val Ile Val Phe 
225                 230                 235                 240 


Phe Leu Phe Trp Thr Pro Tyr Asn Val Met Ile Phe Leu Glu Thr Leu 
                245                 250                 255     


Lys Leu Tyr Asp Phe Phe Pro Ser Cys Asp Met Arg Lys Asp Leu Arg 
            260                 265                 270         


Leu Ala Leu Ser Val Thr Glu Thr Val Ala Phe Ser His Cys Cys Leu 
        275                 280                 285             


Asn Pro Leu Ile Tyr Ala Phe Ala Gly Glu Lys Phe Arg Arg Tyr Leu 
    290                 295                 300                 


Tyr His Leu Tyr Gly Lys Cys Leu Ala Val Leu Cys Gly Arg Ser Val 
305                 310                 315                 320 


His Val Asp Phe Ser Ser Ser Glu Ser Gln Arg Ser Arg His Gly Ser 
                325                 330                 335     


Val Leu Ser Ser Asn Phe Thr Tyr His Thr Ser Asp Gly Asp Ala Leu 
            340                 345                 350         


Leu Leu Leu 
        355 


<210>  2273
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  2273

Met Asp Gln Phe Pro Glu Ser Val Thr Glu Asn Phe Glu Tyr Asp Asp 
1               5                   10                  15      


Leu Ala Glu Ala Cys Tyr Ile Gly Asp Ile Val Val Phe Gly Thr Val 
            20                  25                  30          


Phe Leu Ser Ile Phe Tyr Ser Val Ile Phe Ala Ile Gly Leu Val Gly 
        35                  40                  45              


Asn Leu Leu Val Val Phe Ala Leu Thr Asn Ser Lys Lys Pro Lys Ser 
    50                  55                  60                  


Val Thr Asp Ile Tyr Leu Leu Asn Leu Ala Leu Ser Asp Leu Leu Phe 
65                  70                  75                  80  


Val Ala Thr Leu Pro Phe Trp Thr His Tyr Leu Ile Asn Glu Lys Gly 
                85                  90                  95      


Leu His Asn Ala Met Cys Lys Phe Thr Thr Ala Phe Phe Phe Ile Gly 
            100                 105                 110         


Phe Phe Gly Ser Ile Phe Phe Ile Thr Val Ile Ser Ile Asp Arg Tyr 
        115                 120                 125             


Leu Ala Ile Val Leu Ala Ala Asn Ser Met Asn Asn Arg Thr Val Gln 
    130                 135                 140                 


His Gly Val Thr Ile Ser Leu Gly Val Trp Ala Ala Ala Ile Leu Val 
145                 150                 155                 160 


Ala Ala Pro Gln Phe Met Phe Thr Lys Gln Lys Glu Asn Glu Cys Leu 
                165                 170                 175     


Gly Asp Tyr Pro Glu Val Leu Gln Glu Ile Trp Pro Val Leu Arg Asn 
            180                 185                 190         


Val Glu Thr Asn Phe Leu Gly Phe Leu Leu Pro Leu Leu Ile Met Ser 
        195                 200                 205             


Tyr Cys Tyr Phe Arg Ile Ile Gln Thr Leu Phe Ser Cys Lys Asn His 
    210                 215                 220                 


Lys Lys Ala Lys Ala Ile Lys Leu Ile Leu Leu Val Val Ile Val Phe 
225                 230                 235                 240 


Phe Leu Phe Trp Thr Pro Tyr Asn Val Met Ile Phe Leu Glu Thr Leu 
                245                 250                 255     


Lys Leu Tyr Asp Phe Phe Pro Ser Cys Asp Met Arg Lys Asp Leu Arg 
            260                 265                 270         


Leu Ala Leu Ser Val Thr Glu Thr Val Ala Phe Ser His Cys Cys Leu 
        275                 280                 285             


Asn Pro Leu Ile Tyr Ala Phe Ala Gly Glu Lys Phe Arg Arg Tyr Leu 
    290                 295                 300                 


Tyr His Leu Tyr Gly Lys Cys Leu Ala Val Leu Cys Gly Arg Ser Val 
305                 310                 315                 320 


His Val Asp Phe Ser Ser Ser Glu Ser Gln Arg Ser Arg His Gly Ser 
                325                 330                 335     


Val Leu Ser Ser Asn Phe Thr Tyr His Thr Ser Asp Gly Asp Ala Leu 
            340                 345                 350         


Leu Leu Leu 
        355 


<210>  2274
<211>  387
<212>  PRT
<213>  Homo sapiens

<400>  2274

Met Arg Glu Pro Leu Glu Ala Phe Lys Leu Ala Asp Leu Asp Phe Arg 
1               5                   10                  15      


Lys Ser Ser Leu Ala Ser Gly Trp Arg Met Ala Ser Gly Ala Phe Thr 
            20                  25                  30          


Met Asp Gln Phe Pro Glu Ser Val Thr Glu Asn Phe Glu Tyr Asp Asp 
        35                  40                  45              


Leu Ala Glu Ala Cys Tyr Ile Gly Asp Ile Val Val Phe Gly Thr Val 
    50                  55                  60                  


Phe Leu Ser Ile Phe Tyr Ser Val Ile Phe Ala Ile Gly Leu Val Gly 
65                  70                  75                  80  


Asn Leu Leu Val Val Phe Ala Leu Thr Asn Ser Lys Lys Pro Lys Ser 
                85                  90                  95      


Val Thr Asp Ile Tyr Leu Leu Asn Leu Ala Leu Ser Asp Leu Leu Phe 
            100                 105                 110         


Val Ala Thr Leu Pro Phe Trp Thr His Tyr Leu Ile Asn Glu Lys Gly 
        115                 120                 125             


Leu His Asn Ala Met Cys Lys Phe Thr Thr Ala Phe Phe Phe Ile Gly 
    130                 135                 140                 


Phe Phe Gly Ser Ile Phe Phe Ile Thr Val Ile Ser Ile Asp Arg Tyr 
145                 150                 155                 160 


Leu Ala Ile Val Leu Ala Ala Asn Ser Met Asn Asn Arg Thr Val Gln 
                165                 170                 175     


His Gly Val Thr Ile Ser Leu Gly Val Trp Ala Ala Ala Ile Leu Val 
            180                 185                 190         


Ala Ala Pro Gln Phe Met Phe Thr Lys Gln Lys Glu Asn Glu Cys Leu 
        195                 200                 205             


Gly Asp Tyr Pro Glu Val Leu Gln Glu Ile Trp Pro Val Leu Arg Asn 
    210                 215                 220                 


Val Glu Thr Asn Phe Leu Gly Phe Leu Leu Pro Leu Leu Ile Met Ser 
225                 230                 235                 240 


Tyr Cys Tyr Phe Arg Ile Ile Gln Thr Leu Phe Ser Cys Lys Asn His 
                245                 250                 255     


Lys Lys Ala Lys Ala Ile Lys Leu Ile Leu Leu Val Val Ile Val Phe 
            260                 265                 270         


Phe Leu Phe Trp Thr Pro Tyr Asn Val Met Ile Phe Leu Glu Thr Leu 
        275                 280                 285             


Lys Leu Tyr Asp Phe Phe Pro Ser Cys Asp Met Arg Lys Asp Leu Arg 
    290                 295                 300                 


Leu Ala Leu Ser Val Thr Glu Thr Val Ala Phe Ser His Cys Cys Leu 
305                 310                 315                 320 


Asn Pro Leu Ile Tyr Ala Phe Ala Gly Glu Lys Phe Arg Arg Tyr Leu 
                325                 330                 335     


Tyr His Leu Tyr Gly Lys Cys Leu Ala Val Leu Cys Gly Arg Ser Val 
            340                 345                 350         


His Val Asp Phe Ser Ser Ser Glu Ser Gln Arg Ser Arg His Gly Ser 
        355                 360                 365             


Val Leu Ser Ser Asn Phe Thr Tyr His Thr Ser Asp Gly Asp Ala Leu 
    370                 375                 380                 


Leu Leu Leu 
385         


<210>  2275
<211>  460
<212>  PRT
<213>  Homo sapiens

<400>  2275

Met Asp Trp Ser Leu Ala Phe Leu Leu Val Ile Ser Leu Leu Val Thr 
1               5                   10                  15      


Tyr Ala Ser Leu Leu Leu Val Leu Ala Leu Leu Leu Arg Leu Cys Arg 
            20                  25                  30          


Gln Pro Leu His Leu His Ser Leu His Lys Val Leu Leu Leu Leu Ile 
        35                  40                  45              


Met Leu Leu Val Ala Ala Gly Leu Val Gly Leu Asp Ile Gln Trp Gln 
    50                  55                  60                  


Gln Glu Trp His Ser Leu Arg Val Ser Leu Gln Ala Thr Ala Pro Phe 
65                  70                  75                  80  


Leu His Ile Gly Ala Ala Ala Gly Ile Ala Leu Leu Ala Trp Pro Val 
                85                  90                  95      


Ala Asp Thr Phe Tyr Arg Ile His Arg Arg Gly Pro Lys Ile Leu Leu 
            100                 105                 110         


Leu Leu Leu Phe Phe Gly Val Val Leu Val Ile Tyr Leu Ala Pro Leu 
        115                 120                 125             


Cys Ile Ser Ser Pro Cys Ile Met Glu Pro Arg Asp Leu Pro Pro Lys 
    130                 135                 140                 


Pro Gly Leu Val Gly His Arg Gly Ala Pro Met Leu Ala Pro Glu Asn 
145                 150                 155                 160 


Thr Leu Met Ser Leu Arg Lys Thr Ala Glu Cys Gly Ala Thr Val Phe 
                165                 170                 175     


Glu Thr Asp Val Met Val Ser Ser Asp Gly Val Pro Phe Leu Met His 
            180                 185                 190         


Asp Glu His Leu Ser Arg Thr Thr Asn Val Ala Ser Val Phe Pro Thr 
        195                 200                 205             


Arg Ile Thr Ala His Ser Ser Asp Phe Ser Trp Thr Glu Leu Lys Arg 
    210                 215                 220                 


Leu Asn Ala Gly Ser Trp Phe Leu Glu Arg Arg Pro Phe Trp Gly Ala 
225                 230                 235                 240 


Lys Pro Leu Ala Gly Pro Asp Gln Lys Glu Ala Glu Ser Gln Thr Val 
                245                 250                 255     


Pro Ala Leu Glu Glu Leu Leu Glu Glu Ala Ala Ala Leu Asn Leu Ser 
            260                 265                 270         


Ile Met Phe Asp Leu Arg Arg Pro Pro Gln Asn His Thr Tyr Tyr Asp 
        275                 280                 285             


Thr Phe Val Ile Gln Thr Leu Glu Thr Val Leu Asn Ala Arg Val Pro 
    290                 295                 300                 


Gln Ala Met Val Phe Trp Leu Pro Asp Glu Asp Arg Ala Asn Val Gln 
305                 310                 315                 320 


Arg Arg Ala Pro Gly Met Arg Gln Ile Tyr Gly Arg Gln Gly Gly Asn 
                325                 330                 335     


Arg Thr Glu Arg Pro Gln Phe Leu Asn Leu Pro Tyr Gln Asp Leu Pro 
            340                 345                 350         


Leu Leu Asp Ile Lys Ala Leu His Lys Asp Asn Val Ser Val Asn Leu 
        355                 360                 365             


Phe Val Val Asn Lys Pro Trp Leu Phe Ser Leu Leu Trp Cys Ala Gly 
    370                 375                 380                 


Val Asp Ser Val Thr Thr Asn Asp Cys Gln Leu Leu Gln Gln Met Arg 
385                 390                 395                 400 


Tyr Pro Ile Trp Leu Ile Thr Pro Gln Thr Tyr Leu Ile Ile Trp Val 
                405                 410                 415     


Ile Thr Asn Cys Val Ser Thr Met Leu Leu Leu Trp Thr Phe Leu Leu 
            420                 425                 430         


Gln Arg Arg Phe Val Lys Lys Arg Gly Lys Thr Gly Leu Glu Thr Ala 
        435                 440                 445             


Val Leu Leu Thr Arg Ile Asn Asn Phe Met Met Glu 
    450                 455                 460 


<210>  2276
<211>  590
<212>  PRT
<213>  Homo sapiens

<400>  2276

Met Ala Glu Ser Pro Gly Cys Cys Ser Val Trp Ala Arg Cys Leu His 
1               5                   10                  15      


Cys Leu Tyr Ser Cys His Trp Arg Lys Cys Pro Arg Glu Arg Met Gln 
            20                  25                  30          


Thr Ser Lys Cys Asp Cys Ile Trp Phe Gly Leu Leu Phe Leu Thr Phe 
        35                  40                  45              


Leu Leu Ser Leu Ser Trp Leu Tyr Ile Gly Leu Val Leu Leu Asn Asp 
    50                  55                  60                  


Leu His Asn Phe Asn Glu Phe Leu Phe Arg Arg Trp Gly His Trp Met 
65                  70                  75                  80  


Asp Trp Ser Leu Ala Phe Leu Leu Val Ile Ser Leu Leu Val Thr Tyr 
                85                  90                  95      


Ala Ser Leu Leu Leu Val Leu Ala Leu Leu Leu Arg Leu Cys Arg Gln 
            100                 105                 110         


Pro Leu His Leu His Ser Leu His Lys Val Leu Leu Leu Leu Ile Met 
        115                 120                 125             


Leu Leu Val Ala Ala Gly Leu Val Gly Leu Asp Ile Gln Trp Gln Gln 
    130                 135                 140                 


Glu Trp His Ser Leu Arg Val Ser Leu Gln Ala Thr Ala Pro Phe Leu 
145                 150                 155                 160 


His Ile Gly Ala Ala Ala Gly Ile Ala Leu Leu Ala Trp Pro Val Ala 
                165                 170                 175     


Asp Thr Phe Tyr Arg Ile His Arg Arg Gly Pro Lys Ile Leu Leu Leu 
            180                 185                 190         


Leu Leu Phe Phe Gly Val Val Leu Val Ile Tyr Leu Ala Pro Leu Cys 
        195                 200                 205             


Ile Ser Ser Pro Cys Ile Met Glu Pro Arg Asp Leu Pro Pro Lys Pro 
    210                 215                 220                 


Gly Leu Val Gly His Arg Gly Ala Pro Met Leu Ala Pro Glu Asn Thr 
225                 230                 235                 240 


Leu Met Ser Leu Arg Lys Thr Ala Glu Cys Gly Ala Thr Val Phe Glu 
                245                 250                 255     


Thr Asp Val Met Val Ser Ser Asp Gly Val Pro Phe Leu Met His Asp 
            260                 265                 270         


Glu His Leu Ser Arg Thr Thr Asn Val Ala Ser Val Phe Pro Thr Arg 
        275                 280                 285             


Ile Thr Ala His Ser Ser Asp Phe Ser Trp Thr Glu Leu Lys Arg Leu 
    290                 295                 300                 


Asn Ala Gly Ser Trp Phe Leu Glu Arg Arg Pro Phe Trp Gly Ala Lys 
305                 310                 315                 320 


Pro Leu Ala Gly Pro Asp Gln Lys Glu Ala Glu Ser Gln Thr Val Pro 
                325                 330                 335     


Ala Leu Glu Glu Leu Leu Glu Glu Ala Ala Ala Leu Asn Leu Ser Ile 
            340                 345                 350         


Met Phe Asp Leu Arg Arg Pro Pro Gln Asn His Thr Tyr Tyr Asp Thr 
        355                 360                 365             


Phe Val Ile Gln Thr Leu Glu Thr Val Leu Asn Ala Arg Val Pro Gln 
    370                 375                 380                 


Ala Met Val Phe Trp Leu Pro Asp Glu Asp Arg Ala Asn Val Gln Arg 
385                 390                 395                 400 


Arg Ala Pro Gly Met Arg Gln Ile Tyr Gly Arg Gln Gly Gly Asn Arg 
                405                 410                 415     


Thr Glu Arg Pro Gln Phe Leu Asn Leu Pro Tyr Gln Asp Leu Pro Leu 
            420                 425                 430         


Leu Asp Ile Lys Asp Arg Phe Leu Leu Pro Ala Gln Ala Gly Leu Lys 
        435                 440                 445             


Leu Leu Ala Ser Ser Asn Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly 
    450                 455                 460                 


Ile Thr Gly Leu Ser His Cys Pro Pro Gln Pro Pro Gly Tyr Lys His 
465                 470                 475                 480 


Glu Leu Ser His Leu Ala Met Ala Leu His Lys Asp Asn Val Ser Val 
                485                 490                 495     


Asn Leu Phe Val Val Asn Lys Pro Trp Leu Phe Ser Leu Leu Trp Cys 
            500                 505                 510         


Ala Gly Val Asp Ser Val Thr Thr Asn Asp Cys Gln Leu Leu Gln Gln 
        515                 520                 525             


Met Arg Tyr Pro Ile Trp Leu Ile Thr Pro Gln Thr Tyr Leu Ile Ile 
    530                 535                 540                 


Trp Val Ile Thr Asn Cys Val Ser Thr Met Leu Leu Leu Trp Thr Phe 
545                 550                 555                 560 


Leu Leu Gln Arg Arg Phe Val Lys Lys Arg Gly Lys Thr Gly Leu Glu 
                565                 570                 575     


Thr Ala Val Leu Leu Thr Arg Ile Asn Asn Phe Met Met Glu 
            580                 585                 590 


<210>  2277
<211>  460
<212>  PRT
<213>  Homo sapiens

<400>  2277

Met Asp Trp Ser Leu Ala Phe Leu Leu Val Ile Ser Leu Leu Val Thr 
1               5                   10                  15      


Tyr Ala Ser Leu Leu Leu Val Leu Ala Leu Leu Leu Arg Leu Cys Arg 
            20                  25                  30          


Gln Pro Leu His Leu His Ser Leu His Lys Val Leu Leu Leu Leu Ile 
        35                  40                  45              


Met Leu Leu Val Ala Ala Gly Leu Val Gly Leu Asp Ile Gln Trp Gln 
    50                  55                  60                  


Gln Glu Trp His Ser Leu Arg Val Ser Leu Gln Ala Thr Ala Pro Phe 
65                  70                  75                  80  


Leu His Ile Gly Ala Ala Ala Gly Ile Ala Leu Leu Ala Trp Pro Val 
                85                  90                  95      


Ala Asp Thr Phe Tyr Arg Ile His Arg Arg Gly Pro Lys Ile Leu Leu 
            100                 105                 110         


Leu Leu Leu Phe Phe Gly Val Val Leu Val Ile Tyr Leu Ala Pro Leu 
        115                 120                 125             


Cys Ile Ser Ser Pro Cys Ile Met Glu Pro Arg Asp Leu Pro Pro Lys 
    130                 135                 140                 


Pro Gly Leu Val Gly His Arg Gly Ala Pro Met Leu Ala Pro Glu Asn 
145                 150                 155                 160 


Thr Leu Met Ser Leu Arg Lys Thr Ala Glu Cys Gly Ala Thr Val Phe 
                165                 170                 175     


Glu Thr Asp Val Met Val Ser Ser Asp Gly Val Pro Phe Leu Met His 
            180                 185                 190         


Asp Glu His Leu Ser Arg Thr Thr Asn Val Ala Ser Val Phe Pro Thr 
        195                 200                 205             


Arg Ile Thr Ala His Ser Ser Asp Phe Ser Trp Thr Glu Leu Lys Arg 
    210                 215                 220                 


Leu Asn Ala Gly Ser Trp Phe Leu Glu Arg Arg Pro Phe Trp Gly Ala 
225                 230                 235                 240 


Lys Pro Leu Ala Gly Pro Asp Gln Lys Glu Ala Glu Ser Gln Thr Val 
                245                 250                 255     


Pro Ala Leu Glu Glu Leu Leu Glu Glu Ala Ala Ala Leu Asn Leu Ser 
            260                 265                 270         


Ile Met Phe Asp Leu Arg Arg Pro Pro Gln Asn His Thr Tyr Tyr Asp 
        275                 280                 285             


Thr Phe Val Ile Gln Thr Leu Glu Thr Val Leu Asn Ala Arg Val Pro 
    290                 295                 300                 


Gln Ala Met Val Phe Trp Leu Pro Asp Glu Asp Arg Ala Asn Val Gln 
305                 310                 315                 320 


Arg Arg Ala Pro Gly Met Arg Gln Ile Tyr Gly Arg Gln Gly Gly Asn 
                325                 330                 335     


Arg Thr Glu Arg Pro Gln Phe Leu Asn Leu Pro Tyr Gln Asp Leu Pro 
            340                 345                 350         


Leu Leu Asp Ile Lys Ala Leu His Lys Asp Asn Val Ser Val Asn Leu 
        355                 360                 365             


Phe Val Val Asn Lys Pro Trp Leu Phe Ser Leu Leu Trp Cys Ala Gly 
    370                 375                 380                 


Val Asp Ser Val Thr Thr Asn Asp Cys Gln Leu Leu Gln Gln Met Arg 
385                 390                 395                 400 


Tyr Pro Ile Trp Leu Ile Thr Pro Gln Thr Tyr Leu Ile Ile Trp Val 
                405                 410                 415     


Ile Thr Asn Cys Val Ser Thr Met Leu Leu Leu Trp Thr Phe Leu Leu 
            420                 425                 430         


Gln Arg Arg Phe Val Lys Lys Arg Gly Lys Thr Gly Leu Glu Thr Ala 
        435                 440                 445             


Val Leu Leu Thr Arg Ile Asn Asn Phe Met Met Glu 
    450                 455                 460 


<210>  2278
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  2278

Met Val Lys Ile Ala Phe Asn Thr Pro Thr Ala Val Gln Lys Glu Glu 
1               5                   10                  15      


Ala Arg Gln Asp Val Glu Ala Leu Leu Ser Arg Thr Val Arg Thr Gln 
            20                  25                  30          


Ile Leu Thr Gly Lys Ser Thr Ile Tyr Arg Gly Glu Met Cys Phe Phe 
        35                  40                  45              


Asp Ser Glu Asp Pro Ala Asn Ser Leu Arg Gly Gly Glu Pro Asn Phe 
    50                  55                  60                  


Leu Pro Val Thr Glu Glu Ala Asp Ile Arg Glu Asp Asp Asn Ile Ala 
65                  70                  75                  80  


Ile Ile Asp Val Pro Val Pro Ser Phe Ser Asp Ser Asp Pro Ala Ala 
                85                  90                  95      


Ile Ile His Asp Phe Glu Lys Gly Met Thr Ala Tyr Leu Asp Leu Leu 
            100                 105                 110         


Leu Gly Asn Cys Tyr Leu Met Pro Leu Asn Thr Ser Ile Val Met Pro 
        115                 120                 125             


Pro Lys Asn Leu Val Glu Leu Phe Gly Lys Leu Ala Ser Gly Arg Tyr 
    130                 135                 140                 


Leu Pro Gln Thr Tyr Val Val Arg Glu Asp Leu Val Ala Val Glu Glu 
145                 150                 155                 160 


Ile Arg Asp Val Ser Asn Leu Gly Ile Phe Ile Tyr Gln Leu Cys Asn 
                165                 170                 175     


Asn Arg Lys Ser Phe Arg Leu Arg Arg Arg Asp Leu Leu Leu Gly Phe 
            180                 185                 190         


Asn Lys Arg Ala Ile Asp Lys Cys Trp Lys Ile Arg His Phe Pro Asn 
        195                 200                 205             


Glu Phe Ile Val Glu Thr Lys Ile Cys Gln Glu 
    210                 215                 


<210>  2279
<211>  568
<212>  PRT
<213>  Homo sapiens

<400>  2279

Met Glu Pro Cys Thr Ser Asp Glu Phe Phe Gln Ala Leu Asn His Ala 
1               5                   10                  15      


Glu Gln Thr Phe Lys Lys Met Glu Asn Tyr Leu Arg His Lys Gln Leu 
            20                  25                  30          


Cys Asp Val Ile Leu Val Ala Gly Asp Arg Arg Ile Pro Ala His Arg 
        35                  40                  45              


Leu Val Leu Ser Ser Val Ser Asp Tyr Phe Ala Ala Met Phe Thr Asn 
    50                  55                  60                  


Asp Val Arg Glu Ala Arg Gln Glu Glu Ile Lys Met Glu Gly Val Glu 
65                  70                  75                  80  


Pro Asn Ser Leu Trp Ser Leu Ile Gln Tyr Ala Tyr Thr Gly Arg Leu 
                85                  90                  95      


Glu Leu Lys Glu Asp Asn Ile Glu Cys Leu Leu Ser Thr Ala Cys Leu 
            100                 105                 110         


Leu Gln Leu Ser Gln Val Val Glu Ala Cys Cys Lys Phe Leu Met Lys 
        115                 120                 125             


Gln Leu His Pro Ser Asn Cys Leu Gly Ile Arg Ser Phe Ala Asp Ala 
    130                 135                 140                 


Gln Gly Cys Thr Asp Leu His Lys Val Ala His Asn Tyr Thr Met Glu 
145                 150                 155                 160 


His Phe Met Glu Val Ile Arg Asn Gln Glu Phe Val Leu Leu Pro Ala 
                165                 170                 175     


Ser Glu Ile Ala Lys Leu Leu Ala Ser Asp Asp Met Asn Ile Pro Asn 
            180                 185                 190         


Glu Glu Thr Ile Leu Asn Ala Leu Leu Thr Trp Val Arg His Asp Leu 
        195                 200                 205             


Glu Gln Arg Arg Lys Asp Leu Ser Lys Leu Leu Ala Tyr Ile Arg Leu 
    210                 215                 220                 


Pro Leu Leu Ala Pro Gln Phe Leu Ala Asp Met Glu Asn Asn Val Leu 
225                 230                 235                 240 


Phe Arg Asp Asp Ile Glu Cys Gln Lys Leu Ile Met Glu Ala Met Lys 
                245                 250                 255     


Tyr His Leu Leu Pro Glu Arg Arg Pro Met Leu Gln Ser Pro Arg Thr 
            260                 265                 270         


Lys Pro Arg Lys Ser Thr Val Gly Thr Leu Phe Ala Val Gly Gly Met 
        275                 280                 285             


Asp Ser Thr Lys Gly Ala Thr Ser Ile Glu Lys Tyr Asp Leu Arg Thr 
    290                 295                 300                 


Asn Met Trp Thr Pro Val Ala Asn Met Asn Gly Arg Arg Leu Gln Phe 
305                 310                 315                 320 


Gly Val Ala Val Leu Asp Asp Lys Leu Tyr Val Val Gly Gly Arg Asp 
                325                 330                 335     


Gly Leu Lys Thr Leu Asn Thr Val Glu Cys Tyr Asn Pro Lys Thr Lys 
            340                 345                 350         


Thr Trp Ser Val Met Pro Pro Met Ser Thr His Arg His Gly Leu Gly 
        355                 360                 365             


Val Ala Val Leu Glu Gly Pro Met Tyr Ala Val Gly Gly His Asp Gly 
    370                 375                 380                 


Trp Ser Tyr Leu Asn Thr Val Glu Arg Trp Asp Pro Gln Ala Arg Gln 
385                 390                 395                 400 


Trp Asn Phe Val Ala Thr Met Ser Thr Pro Arg Ser Thr Val Gly Val 
                405                 410                 415     


Ala Val Leu Ser Gly Lys Leu Tyr Ala Val Gly Gly Arg Asp Gly Ser 
            420                 425                 430         


Ser Cys Leu Lys Ser Val Glu Cys Phe Asp Pro His Thr Asn Lys Trp 
        435                 440                 445             


Thr Leu Cys Ala Gln Met Ser Lys Arg Arg Gly Gly Val Gly Val Thr 
    450                 455                 460                 


Thr Trp Asn Gly Leu Leu Tyr Ala Ile Gly Gly His Asp Ala Pro Ala 
465                 470                 475                 480 


Ser Asn Leu Thr Ser Arg Leu Ser Asp Cys Val Glu Arg Tyr Asp Pro 
                485                 490                 495     


Lys Thr Asp Met Trp Thr Ala Val Ala Ser Met Ser Ile Ser Arg Asp 
            500                 505                 510         


Ala Val Gly Val Cys Leu Leu Gly Asp Lys Leu Tyr Ala Val Gly Gly 
        515                 520                 525             


Tyr Asp Gly Gln Ala Tyr Leu Asn Thr Val Glu Ala Tyr Asp Pro Gln 
    530                 535                 540                 


Thr Asn Glu Trp Thr Gln Val Ala Pro Leu Cys Leu Gly Arg Ala Gly 
545                 550                 555                 560 


Ala Cys Val Val Thr Val Lys Leu 
                565             


<210>  2280
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  2280

Met Asn Ser Arg Thr Ala Ser Ala Arg Gly Trp Phe Ser Ser Arg Pro 
1               5                   10                  15      


Pro Thr Ser Glu Ser Asp Leu Glu Pro Ala Thr Asp Gly Pro Ala Ser 
            20                  25                  30          


Glu Thr Thr Thr Leu Ser Pro Glu Ala Thr Thr Phe Asn Asp Thr Arg 
        35                  40                  45              


Ile Pro Asp Ala Ala Gly Gly Thr Ala Gly Val Gly Thr Met Leu Leu 
    50                  55                  60                  


Ser Phe Gly Ile Ile Thr Val Ile Gly Leu Ala Val Ala Leu Val Leu 
65                  70                  75                  80  


Tyr Ile Arg Lys Lys Lys Arg Leu Glu Lys Leu Arg His Gln Leu Met 
                85                  90                  95      


Pro Met Tyr Asn Phe Asp Pro Thr Glu Glu Gln Asp Glu Leu Glu Gln 
            100                 105                 110         


Glu Leu Leu Glu His Gly Arg Asp Ala Ala Ser Val Gln Ala Ala Thr 
        115                 120                 125             


Ser Val Gln Ala Met Gln Gly Lys Thr Thr Leu Pro Ser Gln Gly Pro 
    130                 135                 140                 


Leu Gln Arg Pro Ser Arg Leu Val Phe Thr Asp Val Ala Asn Ala Ile 
145                 150                 155                 160 


His Ala 
        


<210>  2281
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  2281

Met Asn Ser Arg Thr Ala Ser Ala Arg Gly Trp Phe Ser Ser Arg Pro 
1               5                   10                  15      


Pro Thr Ser Glu Ser Asp Leu Glu Pro Ala Thr Asp Gly Pro Ala Ser 
            20                  25                  30          


Glu Thr Thr Thr Leu Ser Pro Glu Ala Thr Thr Phe Asn Asp Thr Arg 
        35                  40                  45              


Ile Pro Asp Ala Ala Gly Gly Thr Ala Gly Val Gly Thr Met Leu Leu 
    50                  55                  60                  


Ser Phe Gly Ile Ile Thr Val Ile Gly Leu Ala Val Ala Leu Val Leu 
65                  70                  75                  80  


Tyr Ile Arg Lys Lys Lys Arg Leu Glu Lys Leu Arg His Gln Leu Met 
                85                  90                  95      


Pro Met Tyr Asn Phe Asp Pro Thr Glu Glu Gln Asp Glu Leu Glu Gln 
            100                 105                 110         


Glu Leu Leu Glu His Gly Arg Asp Ala Ala Ser Val Gln Ala Ala Thr 
        115                 120                 125             


Ser Val Gln Ala Met Gln Gly Lys Thr Thr Leu Pro Ser Gln Gly Pro 
    130                 135                 140                 


Leu Gln Arg Pro Ser Arg Leu Val Phe Thr Asp Val Ala Asn Ala Ile 
145                 150                 155                 160 


His Ala 
        


<210>  2282
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  2282

Met Asn Ser Arg Thr Ala Ser Ala Arg Gly Trp Phe Ser Ser Arg Pro 
1               5                   10                  15      


Pro Thr Ser Glu Ser Asp Leu Glu Pro Ala Thr Asp Gly Pro Ala Ser 
            20                  25                  30          


Glu Thr Thr Thr Leu Ser Pro Glu Ala Thr Thr Phe Asn Asp Thr Arg 
        35                  40                  45              


Ile Pro Asp Ala Ala Gly Gly Thr Ala Gly Val Leu Tyr Ile Arg Lys 
    50                  55                  60                  


Lys Lys Arg Leu Glu Lys Leu Arg His Gln Leu Met Pro Met Tyr Asn 
65                  70                  75                  80  


Phe Asp Pro Thr Glu Glu Gln Asp Glu Leu Glu Gln Glu Leu Leu Glu 
                85                  90                  95      


His Gly Arg Asp Ala Ala Ser Val Gln Ala Ala Thr Ser Val Gln Ala 
            100                 105                 110         


Met Gln Gly Lys Thr Thr Leu Pro Ser Gln Gly Pro Leu Gln Arg Pro 
        115                 120                 125             


Ser Arg Leu Val Phe Thr Asp Val Ala Asn Ala Ile His Ala 
    130                 135                 140         


<210>  2283
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  2283

Met Asp Leu Ala Gln Pro Ser Gln Pro Val Asp Glu Leu Glu Leu Ser 
1               5                   10                  15      


Val Leu Glu Arg Gln Pro Glu Glu Asn Thr Pro Leu Asn Gly Ala Asp 
            20                  25                  30          


Lys Val Phe Pro Ser Leu Asp Glu Glu Val Pro Pro Ala Glu Ala Asn 
        35                  40                  45              


Lys Glu Ser Pro Trp Ser Ser Cys Asn Lys Asn Val Val Gly Arg Cys 
    50                  55                  60                  


Lys Leu Trp Met Ile Ile Thr Ser Ile Phe Leu Gly Val Ile Thr Val 
65                  70                  75                  80  


Ile Ile Ile Gly Leu Cys Leu Ala Ala Val Thr Tyr Val Asp Glu Asp 
                85                  90                  95      


Glu Asn Glu Ile Leu Glu Leu Ser Ser Asn Lys Thr Phe Phe Ile Met 
            100                 105                 110         


Leu Lys Ile Pro Glu Glu Cys Val Ala Glu Glu Glu Leu Pro His Leu 
        115                 120                 125             


Leu Thr Glu Arg Asn Glu Val Met Glu Ala Gly Leu Cys Leu Lys Ala 
    130                 135                 140                 


Val Leu Tyr Gln Val Leu Glu Met Lys Gly Ile His Ser Val Leu Gln 
145                 150                 155                 160 


Lys Arg Phe Cys Gly Leu Ile Gln Lys His Gln Gln His Gln Arg Gly 
                165                 170                 175     


Gly Asp Ser Phe Leu Ser Arg Phe Tyr Ser Leu Ala Leu Ser Pro Val 
            180                 185                 190         


Lys Gln Leu Pro Ser Thr Ala Ser Ala Gly Ser Ser Leu Asp Lys Gly 
        195                 200                 205             


Arg Lys Pro Ala Arg Val Gly Ala Ile Gly Ser Ala Gly Met Ser His 
    210                 215                 220                 


Cys Trp Arg Ser Leu Val Phe Cys Leu Phe Leu Phe Cys Phe Val Leu 
225                 230                 235                 240 


Phe Phe Glu Thr Gly Ser Arg Ser Val Ala 
                245                 250 


<210>  2284
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  2284

Met Gly Arg Lys Asp Ala Ala Thr Ile Lys Leu Pro Val Asp Gln Tyr 
1               5                   10                  15      


Arg Lys Gln Ile Gly Lys Gln Asp Tyr Lys Lys Thr Lys Pro Ile Leu 
            20                  25                  30          


Arg Ala Thr Lys Leu Lys Ala Glu Ala Lys Lys Thr Ala Ile Gly Ile 
        35                  40                  45              


Lys Glu Val Gly Leu Val Leu Ala Ala Ile Leu Ala Leu Leu Leu Ala 
    50                  55                  60                  


Phe Tyr Ala Phe Phe Tyr Leu Arg Leu Thr Thr Asp Val Asp Pro Asp 
65                  70                  75                  80  


Leu Asp Gln Asp Glu Asp 
                85      


<210>  2285
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  2285

Met Gly Arg Lys Asp Ala Ala Thr Ile Lys Leu Pro Val Asp Gln Tyr 
1               5                   10                  15      


Arg Lys Gln Ile Gly Lys Gln Asp Tyr Lys Lys Thr Lys Pro Ile Leu 
            20                  25                  30          


Arg Ala Thr Lys Leu Lys Ala Glu Ala Lys Lys Thr Ala Ile Gly Ile 
        35                  40                  45              


Lys Glu Val Gly Leu Val Leu Ala Ala Ile Leu Ala Leu Leu Leu Ala 
    50                  55                  60                  


Phe Tyr Ala Phe Phe Tyr Leu Arg Leu Thr Thr Asp Val Asp Pro Asp 
65                  70                  75                  80  


Leu Asp Gln Asp Glu Asp 
                85      


<210>  2286
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  2286

Met Gly Arg Lys Asp Ala Ala Thr Ile Lys Leu Pro Val Asp Gln Tyr 
1               5                   10                  15      


Arg Lys Gln Ile Gly Lys Gln Asp Tyr Lys Lys Thr Lys Pro Ile Leu 
            20                  25                  30          


Arg Ala Thr Lys Leu Lys Ala Glu Ala Lys Lys Thr Ala Ile Gly Ile 
        35                  40                  45              


Lys Glu Val Gly Leu Val Leu Ala Ala Ile Leu Ala Leu Leu Leu Ala 
    50                  55                  60                  


Phe Tyr Ala Phe Phe Tyr Leu Arg Leu Thr Thr Asp Val Asp Pro Asp 
65                  70                  75                  80  


Leu Asp Gln Asp Glu Asp 
                85      


<210>  2287
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  2287

Met Gly Arg Lys Asp Ala Ala Thr Ile Lys Leu Pro Val Asp Gln Tyr 
1               5                   10                  15      


Arg Lys Gln Ile Gly Lys Gln Asp Tyr Lys Lys Thr Lys Pro Ile Leu 
            20                  25                  30          


Arg Ala Thr Lys Leu Lys Ala Glu Ala Lys Lys Thr Ala Ile Gly Ile 
        35                  40                  45              


Lys Glu Val Gly Leu Val Leu Ala Ala Ile Leu Ala Leu Leu Leu Ala 
    50                  55                  60                  


Phe Tyr Ala Phe Phe Tyr Leu Arg Leu Thr Thr Asp Val Asp Pro Asp 
65                  70                  75                  80  


Leu Asp Gln Asp Glu Asp 
                85      


<210>  2288
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  2288

Met Gly Arg Lys Asp Ala Ala Thr Ile Lys Leu Pro Val Asp Gln Tyr 
1               5                   10                  15      


Arg Lys Gln Ile Gly Lys Gln Asp Tyr Lys Lys Thr Lys Pro Ile Leu 
            20                  25                  30          


Arg Ala Thr Lys Leu Lys Ala Glu Ala Lys Lys Thr Ala Ile Gly Ile 
        35                  40                  45              


Lys Glu Val Gly Leu Val Leu Ala Ala Ile Leu Ala Leu Leu Leu Ala 
    50                  55                  60                  


Phe Tyr Ala Phe Phe Tyr Leu Arg Leu Thr Thr Asp Val Asp Pro Asp 
65                  70                  75                  80  


Leu Asp Gln Asp Glu Asp 
                85      


<210>  2289
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  2289

Met Thr Ala Gly Ser Pro Glu Glu Cys Gly Glu Val Arg Arg Ser Pro 
1               5                   10                  15      


Glu Gly Arg Val Ser Arg Leu Gly Arg Arg Leu Gly Arg Arg Arg Arg 
            20                  25                  30          


Pro Arg Ser Pro Pro Glu Pro Leu Arg Val Arg Ala Arg Leu Arg Leu 
        35                  40                  45              


Arg Ser Pro Ser Gly Ala Phe Ala Ala Leu Gly Ala Leu Val Val Leu 
    50                  55                  60                  


Val Gly Met Gly Ile Ala Val Ala Gly Tyr Trp Pro His Arg Ala Gly 
65                  70                  75                  80  


Ala Pro Gly Ser Arg Ala Ala Asn Ala Ser Ser Pro Gln Met Ser Glu 
                85                  90                  95      


Leu Arg Arg Glu Gly Arg Gly Gly Gly Arg Ala His Gly Pro His Glu 
            100                 105                 110         


Arg Leu Arg Leu Leu Gly Pro Val Ile Met Gly Val Gly Leu Phe Val 
        115                 120                 125             


Phe Ile Cys Ala Asn Thr Leu Leu Tyr Glu Asn Arg Asp Leu Glu Thr 
    130                 135                 140                 


Arg Arg Leu Arg Gln Gly Val Leu Arg Ala Gln Ala Leu Arg Pro Pro 
145                 150                 155                 160 


Asp Gly Pro Gly Trp Asp Cys Ala Leu Leu Pro Ser Pro Gly Pro Arg 
                165                 170                 175     


Ser Pro Arg Ala Val Gly Cys Ala Glu Pro Glu Ile Trp Asp Pro Ser 
            180                 185                 190         


Pro Arg Arg Gly Thr Ser Pro Val Pro Ser Val Arg Ser Leu Arg Ser 
        195                 200                 205             


Glu Pro Ala Asn Pro Arg Leu Gly Leu Pro Ala Leu Leu Asn Ser Tyr 
    210                 215                 220                 


Pro Leu Lys Gly Pro Gly Leu Pro Pro Pro Trp Gly Pro Arg Thr Gln 
225                 230                 235                 240 


Thr Gly His Val Ile Ile Thr Val Gln Pro Ser Gly Ser Cys Ile Glu 
                245                 250                 255     


His Ser Lys Ser Leu Asp Leu Gly Leu Gly Glu Leu Leu Leu Gly Ala 
            260                 265                 270         


Pro Ala Ala Arg Asp Cys Ala His Arg Ser Trp Pro Arg Leu Asp Arg 
        275                 280                 285             


Leu Ser Leu Gly Gly Tyr Ala Lys Leu Gly Gly Gly Gly Asp Leu Gly 
    290                 295                 300                 


Ala Arg Val 
305         


<210>  2290
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  2290

Met Leu His Gln Ser Gly Lys Phe Leu Ile Pro Asp Ile Lys Glu Glu 
1               5                   10                  15      


Glu Lys Ser Tyr Gln Val Ile Arg Trp Phe Ser Pro Glu Asp His Gln 
            20                  25                  30          


Lys Arg Ile Lys Lys His Phe Asp Ser Tyr Ile Glu Thr Ala Leu Asp 
        35                  40                  45              


Gly Arg Lys Glu Ser Glu Ala Leu Val Lys Leu Met Glu Ile Phe Gly 
    50                  55                  60                  


Thr Gln Cys Ser Tyr Leu Leu Ser Arg Lys Asp Ile Met Asp Ser Leu 
65                  70                  75                  80  


Lys Asn Glu Asn Tyr Asp Leu Val Phe Val Glu Ala Phe Asp Phe Cys 
                85                  90                  95      


Ser Phe Leu Ile Ala Glu Lys Leu Val Lys Pro Phe Val Ala Ile Leu 
            100                 105                 110         


Pro Thr Thr Phe Gly Ser Leu Asp Phe Gly Leu Pro Ser Pro Leu Ser 
        115                 120                 125             


Tyr Val Pro Val Phe Pro Ser Leu Leu Thr Asp His Met Asp Phe Trp 
    130                 135                 140                 


Gly Arg Val Lys Asn Phe Leu Met Phe Phe Ser Phe Ser Arg Ser Gln 
145                 150                 155                 160 


Trp Asp Met Gln Ser Thr Phe Asp Asn Thr Ile Lys Glu His Phe Pro 
                165                 170                 175     


Glu Gly Ser Arg Pro Val Leu Ser His Leu Leu Leu Lys Ala Glu Leu 
            180                 185                 190         


Trp Phe Val Asn Ser Asp Phe Ala Phe Asp Phe Ala Arg Pro Leu Leu 
        195                 200                 205             


Pro Asn Thr Val Tyr Ile Gly Gly Leu Met Glu Lys Pro Ile Lys Pro 
    210                 215                 220                 


Val Pro Gln Asn Gly Gln Pro Ala Leu Phe Thr Thr Pro Ser Leu Phe 
225                 230                 235                 240 


Ser Ser Gly Val Tyr Pro Glu Pro Leu Arg Trp Leu 
                245                 250         


<210>  2291
<211>  1381
<212>  PRT
<213>  Homo sapiens

<400>  2291

Met Gly Arg His Val Ala Thr Ser Cys His Val Ala Trp Leu Leu Val 
1               5                   10                  15      


Leu Ile Ser Gly Cys Trp Gly Gln Val Asn Arg Leu Pro Phe Phe Thr 
            20                  25                  30          


Asn His Phe Phe Asp Thr Tyr Leu Leu Ile Ser Glu Asp Thr Pro Val 
        35                  40                  45              


Gly Ser Ser Val Thr Gln Leu Leu Ala Gln Asp Met Asp Asn Asp Pro 
    50                  55                  60                  


Leu Val Phe Gly Val Ser Gly Glu Glu Ala Ser Arg Phe Phe Ala Val 
65                  70                  75                  80  


Glu Pro Asp Thr Gly Val Val Trp Leu Arg Gln Pro Leu Asp Arg Glu 
                85                  90                  95      


Thr Lys Ser Glu Phe Thr Val Glu Phe Ser Val Ser Asp His Gln Gly 
            100                 105                 110         


Val Ile Thr Arg Lys Val Asn Ile Gln Val Gly Asp Val Asn Asp Asn 
        115                 120                 125             


Ala Pro Thr Phe His Asn Gln Pro Tyr Ser Val Arg Ile Pro Glu Asn 
    130                 135                 140                 


Thr Pro Val Gly Thr Pro Ile Phe Ile Val Asn Ala Thr Asp Pro Asp 
145                 150                 155                 160 


Leu Gly Ala Gly Gly Ser Val Leu Tyr Ser Phe Gln Pro Pro Ser Gln 
                165                 170                 175     


Phe Phe Ala Ile Asp Ser Ala Arg Gly Ile Val Thr Val Ile Arg Glu 
            180                 185                 190         


Leu Asp Tyr Glu Thr Thr Gln Ala Tyr Gln Leu Thr Val Asn Ala Thr 
        195                 200                 205             


Asp Gln Asp Lys Thr Arg Pro Leu Ser Thr Leu Ala Asn Leu Ala Ile 
    210                 215                 220                 


Ile Ile Thr Asp Val Gln Asp Met Asp Pro Ile Phe Ile Asn Leu Pro 
225                 230                 235                 240 


Tyr Ser Thr Asn Ile Tyr Glu His Ser Pro Pro Gly Thr Thr Val Arg 
                245                 250                 255     


Ile Ile Thr Ala Ile Asp Gln Asp Lys Gly Arg Pro Arg Gly Ile Gly 
            260                 265                 270         


Tyr Thr Ile Val Ser Gly Asn Thr Asn Ser Ile Phe Ala Leu Asp Tyr 
        275                 280                 285             


Ile Ser Gly Val Leu Thr Leu Asn Gly Leu Leu Asp Arg Glu Asn Pro 
    290                 295                 300                 


Leu Tyr Ser His Gly Phe Ile Leu Thr Val Lys Gly Thr Glu Leu Asn 
305                 310                 315                 320 


Asp Asp Arg Thr Pro Ser Asp Ala Thr Val Thr Thr Thr Phe Asn Ile 
                325                 330                 335     


Leu Val Ile Asp Ile Asn Asp Asn Ala Pro Glu Phe Asn Ser Ser Glu 
            340                 345                 350         


Tyr Ser Val Ala Ile Thr Glu Leu Ala Gln Val Gly Phe Ala Leu Pro 
        355                 360                 365             


Leu Phe Ile Gln Val Val Asp Lys Asp Glu Asn Leu Gly Leu Asn Ser 
    370                 375                 380                 


Met Phe Glu Val Tyr Leu Val Gly Asn Asn Ser His His Phe Ile Ile 
385                 390                 395                 400 


Ser Pro Thr Ser Val Gln Gly Lys Ala Asp Ile Arg Ile Arg Val Ala 
                405                 410                 415     


Ile Pro Leu Asp Tyr Glu Thr Val Asp Arg Tyr Asp Phe Asp Leu Phe 
            420                 425                 430         


Ala Asn Glu Ser Val Pro Asp His Val Gly Tyr Ala Lys Val Lys Ile 
        435                 440                 445             


Thr Leu Ile Asn Glu Asn Asp Asn Arg Pro Ile Phe Ser Gln Pro Leu 
    450                 455                 460                 


Tyr Asn Ile Ser Leu Tyr Glu Asn Val Thr Val Gly Thr Ser Val Leu 
465                 470                 475                 480 


Thr Val Leu Ala Thr Asp Asn Asp Ala Gly Thr Phe Gly Glu Val Ser 
                485                 490                 495     


Tyr Phe Phe Ser Asp Asp Pro Asp Arg Phe Ser Leu Asp Lys Asp Thr 
            500                 505                 510         


Gly Leu Ile Met Leu Ile Ala Arg Leu Asp Tyr Glu Leu Ile Gln Arg 
        515                 520                 525             


Phe Thr Leu Thr Ile Ile Ala Arg Asp Gly Gly Gly Glu Glu Thr Thr 
    530                 535                 540                 


Gly Arg Val Arg Ile Asn Val Leu Asp Val Asn Asp Asn Val Pro Thr 
545                 550                 555                 560 


Phe Gln Lys Asp Ala Tyr Val Gly Ala Leu Arg Glu Asn Glu Pro Ser 
                565                 570                 575     


Val Thr Gln Leu Val Arg Leu Arg Ala Thr Asp Glu Asp Ser Pro Pro 
            580                 585                 590         


Asn Asn Gln Ile Thr Tyr Ser Ile Val Ser Ala Ser Ala Phe Gly Ser 
        595                 600                 605             


Tyr Phe Asp Ile Ser Leu Tyr Glu Gly Tyr Gly Val Ile Ser Val Ser 
    610                 615                 620                 


Arg Pro Leu Asp Tyr Glu Gln Ile Ser Asn Gly Leu Ile Tyr Leu Thr 
625                 630                 635                 640 


Val Met Ala Met Asp Ala Gly Asn Pro Pro Leu Asn Ser Thr Val Pro 
                645                 650                 655     


Val Thr Ile Glu Val Phe Asp Glu Asn Asp Asn Pro Pro Thr Phe Ser 
            660                 665                 670         


Lys Pro Ala Tyr Phe Val Ser Val Val Glu Asn Ile Met Ala Gly Ala 
        675                 680                 685             


Thr Val Leu Phe Leu Asn Ala Thr Asp Leu Asp Arg Ser Arg Glu Tyr 
    690                 695                 700                 


Gly Gln Glu Ser Ile Ile Tyr Ser Leu Glu Gly Ser Thr Gln Phe Arg 
705                 710                 715                 720 


Ile Asn Ala Arg Ser Gly Glu Ile Thr Thr Thr Ser Leu Leu Asp Arg 
                725                 730                 735     


Glu Thr Lys Ser Glu Tyr Ile Leu Ile Val Arg Ala Val Asp Gly Gly 
            740                 745                 750         


Val Gly His Asn Gln Lys Thr Gly Ile Ala Thr Val Asn Ile Thr Leu 
        755                 760                 765             


Leu Asp Ile Asn Asp Asn His Pro Thr Trp Lys Asp Ala Pro Tyr Tyr 
    770                 775                 780                 


Ile Asn Leu Val Glu Met Thr Pro Pro Asp Ser Asp Val Thr Thr Val 
785                 790                 795                 800 


Val Ala Val Asp Pro Asp Leu Gly Glu Asn Gly Thr Leu Val Tyr Ser 
                805                 810                 815     


Ile Gln Pro Pro Asn Lys Phe Tyr Ser Leu Asn Ser Thr Thr Gly Lys 
            820                 825                 830         


Ile Arg Thr Thr His Ala Met Leu Asp Arg Glu Asn Pro Asp Pro His 
        835                 840                 845             


Glu Ala Glu Leu Met Arg Lys Ile Val Val Ser Val Thr Asp Cys Gly 
    850                 855                 860                 


Arg Pro Pro Leu Lys Ala Thr Ser Ser Ala Thr Val Phe Val Asn Leu 
865                 870                 875                 880 


Leu Asp Leu Asn Asp Asn Asp Pro Thr Phe Gln Asn Leu Pro Phe Val 
                885                 890                 895     


Ala Glu Val Leu Glu Gly Ile Pro Ala Gly Val Ser Ile Tyr Gln Val 
            900                 905                 910         


Val Ala Ile Asp Leu Asp Glu Gly Leu Asn Gly Leu Val Ser Tyr Arg 
        915                 920                 925             


Met Pro Val Gly Met Pro Arg Met Asp Phe Leu Ile Asn Ser Ser Ser 
    930                 935                 940                 


Gly Val Val Val Thr Thr Thr Glu Leu Asp Arg Glu Arg Ile Ala Glu 
945                 950                 955                 960 


Tyr Gln Leu Arg Val Val Ala Ser Asp Ala Gly Thr Pro Thr Lys Ser 
                965                 970                 975     


Ser Thr Ser Thr Leu Thr Ile His Val Leu Asp Val Asn Asp Glu Thr 
            980                 985                 990         


Pro Thr Phe Phe Pro Ala Val Tyr  Asn Val Ser Val Ser  Glu Asp Val 
        995                 1000                 1005             


Pro Arg  Glu Phe Arg Val Val  Trp Leu Asn Cys Thr  Asp Asn Asp 
    1010                 1015                 1020             


Val Gly  Leu Asn Ala Glu Leu  Ser Tyr Phe Ile Thr  Gly Gly Asn 
    1025                 1030                 1035             


Val Asp  Gly Lys Phe Ser Val  Gly Tyr Arg Asp Ala  Val Val Arg 
    1040                 1045                 1050             


Thr Val  Val Gly Leu Asp Arg  Glu Thr Thr Ala Ala  Tyr Met Leu 
    1055                 1060                 1065             


Ile Leu  Glu Ala Ile Asp Asn  Gly Pro Val Gly Lys  Arg His Thr 
    1070                 1075                 1080             


Gly Thr  Ala Thr Val Phe Val  Thr Val Leu Asp Val  Asn Asp Asn 
    1085                 1090                 1095             


Arg Pro  Ile Phe Leu Gln Ser  Ser Tyr Glu Ala Ser  Val Pro Glu 
    1100                 1105                 1110             


Asp Ile  Pro Glu Gly His Ser  Ile Leu Gln Leu Lys  Ala Thr Asp 
    1115                 1120                 1125             


Ala Asp  Glu Gly Glu Phe Gly  Arg Val Trp Tyr Arg  Ile Leu His 
    1130                 1135                 1140             


Gly Asn  His Gly Asn Asn Phe  Arg Ile His Val Ser  Asn Gly Leu 
    1145                 1150                 1155             


Leu Met  Arg Gly Pro Arg Pro  Leu Asp Arg Glu Arg  Asn Ser Ser 
    1160                 1165                 1170             


His Val  Leu Ile Val Glu Ala  Tyr Asn His Asp Leu  Gly Pro Met 
    1175                 1180                 1185             


Arg Ser  Ser Val Arg Val Ile  Val Tyr Val Glu Asp  Ile Asn Asp 
    1190                 1195                 1200             


Glu Ala  Pro Val Phe Thr Gln  Gln Gln Tyr Ser Arg  Leu Gly Leu 
    1205                 1210                 1215             


Arg Glu  Thr Ala Gly Ile Gly  Thr Ser Val Ile Val  Val Gln Ala 
    1220                 1225                 1230             


Thr Asp  Arg Asp Ser Gly Asp  Gly Gly Leu Val Asn  Tyr Arg Ile 
    1235                 1240                 1245             


Leu Ser  Gly Ala Glu Gly Lys  Phe Glu Ile Asp Glu  Ser Thr Gly 
    1250                 1255                 1260             


Leu Ile  Ile Thr Val Asn Tyr  Leu Asp Tyr Glu Thr  Lys Thr Ser 
    1265                 1270                 1275             


Tyr Met  Met Asn Val Ser Ala  Thr Asp Gln Ala Pro  Pro Phe Asn 
    1280                 1285                 1290             


Gln Gly  Phe Cys Ser Val Tyr  Ile Thr Leu Leu Asn  Glu Leu Asp 
    1295                 1300                 1305             


Glu Ala  Val Gln Phe Ser Asn  Ala Ser Tyr Glu Ala  Ala Ile Leu 
    1310                 1315                 1320             


Glu Asn  Leu Ala Leu Gly Thr  Glu Ile Val Arg Val  Gln Ala Tyr 
    1325                 1330                 1335             


Ser Ile  Asp Asn Leu Asn Gln  Ile Thr Tyr Arg Phe  Asn Ala Tyr 
    1340                 1345                 1350             


Thr Ser  Thr Gln Ala Lys Ala  Leu Phe Lys Ile Asp  Ala Ile Thr 
    1355                 1360                 1365             


Val Arg  Gly Trp Gly Gln Gly  Ala Pro Phe Leu Pro  Ile 
    1370                 1375                 1380     


<210>  2292
<211>  1061
<212>  PRT
<213>  Homo sapiens

<400>  2292

Met Gly Arg His Val Ala Thr Ser Cys His Val Ala Trp Leu Leu Val 
1               5                   10                  15      


Leu Ile Ser Gly Cys Trp Gly Gln Val Asn Arg Leu Pro Phe Phe Thr 
            20                  25                  30          


Asn His Phe Phe Asp Thr Tyr Leu Leu Ile Ser Glu Asp Thr Pro Val 
        35                  40                  45              


Gly Ser Ser Val Thr Gln Leu Leu Ala Gln Asp Met Asp Asn Asp Pro 
    50                  55                  60                  


Leu Val Phe Gly Val Ser Gly Glu Glu Ala Ser Arg Phe Phe Ala Val 
65                  70                  75                  80  


Glu Pro Asp Thr Gly Val Val Trp Leu Arg Gln Pro Leu Asp Arg Glu 
                85                  90                  95      


Thr Lys Ser Glu Phe Thr Val Glu Phe Ser Val Ser Asp His Gln Gly 
            100                 105                 110         


Val Ile Thr Arg Lys Val Asn Ile Gln Val Gly Asp Val Asn Asp Asn 
        115                 120                 125             


Ala Pro Thr Phe His Asn Gln Pro Tyr Ser Val Arg Ile Pro Glu Asn 
    130                 135                 140                 


Thr Pro Val Gly Thr Pro Ile Phe Ile Val Asn Ala Thr Asp Pro Asp 
145                 150                 155                 160 


Leu Gly Ala Gly Gly Ser Val Leu Tyr Ser Phe Gln Pro Pro Ser Gln 
                165                 170                 175     


Phe Phe Ala Ile Asp Ser Ala Arg Gly Ile Val Thr Val Ile Arg Glu 
            180                 185                 190         


Leu Asp Tyr Glu Thr Thr Gln Ala Tyr Gln Leu Thr Val Asn Ala Thr 
        195                 200                 205             


Asp Gln Asp Lys Thr Arg Pro Leu Ser Thr Leu Ala Asn Leu Ala Ile 
    210                 215                 220                 


Ile Ile Thr Asp Val Gln Asp Met Asp Pro Ile Phe Ile Asn Leu Pro 
225                 230                 235                 240 


Tyr Ser Thr Asn Ile Tyr Glu His Ser Pro Pro Gly Thr Thr Val Arg 
                245                 250                 255     


Ile Ile Thr Ala Ile Asp Gln Asp Lys Gly Arg Pro Arg Gly Ile Gly 
            260                 265                 270         


Tyr Thr Ile Val Ser Gly Asn Thr Asn Ser Ile Phe Ala Leu Asp Tyr 
        275                 280                 285             


Ile Ser Gly Val Leu Thr Leu Asn Gly Leu Leu Asp Arg Glu Asn Pro 
    290                 295                 300                 


Leu Tyr Ser His Gly Phe Ile Leu Thr Val Lys Gly Thr Glu Leu Asn 
305                 310                 315                 320 


Asp Asp Arg Thr Pro Ser Asp Ala Thr Val Thr Thr Thr Phe Asn Ile 
                325                 330                 335     


Leu Val Ile Asp Ile Asn Asp Asn Ala Pro Glu Phe Asn Ser Ser Glu 
            340                 345                 350         


Tyr Ser Val Ala Ile Thr Glu Leu Ala Gln Val Gly Phe Ala Leu Pro 
        355                 360                 365             


Leu Phe Ile Gln Val Val Asp Lys Asp Glu Asn Leu Gly Leu Asn Ser 
    370                 375                 380                 


Met Phe Glu Val Tyr Leu Val Gly Asn Asn Ser His His Phe Ile Ile 
385                 390                 395                 400 


Ser Pro Thr Ser Val Gln Gly Lys Ala Asp Ile Arg Ile Arg Val Ala 
                405                 410                 415     


Ile Pro Leu Asp Tyr Glu Thr Val Asp Arg Tyr Asp Phe Asp Leu Phe 
            420                 425                 430         


Ala Asn Glu Ser Val Pro Asp His Val Gly Tyr Ala Lys Val Lys Ile 
        435                 440                 445             


Thr Leu Ile Asn Glu Asn Asp Asn Arg Pro Ile Phe Ser Gln Pro Leu 
    450                 455                 460                 


Tyr Asn Ile Ser Leu Tyr Glu Asn Val Thr Val Gly Thr Ser Val Leu 
465                 470                 475                 480 


Thr Val Leu Ala Thr Asp Asn Asp Ala Gly Thr Phe Gly Glu Val Ser 
                485                 490                 495     


Tyr Phe Phe Ser Asp Asp Pro Asp Arg Phe Ser Leu Asp Lys Asp Thr 
            500                 505                 510         


Gly Leu Ile Met Leu Ile Ala Arg Leu Asp Tyr Glu Leu Ile Gln Arg 
        515                 520                 525             


Phe Thr Leu Thr Ile Ile Ala Arg Asp Gly Gly Gly Glu Glu Thr Thr 
    530                 535                 540                 


Gly Arg Val Arg Ile Asn Val Leu Asp Val Asn Asp Asn Val Pro Thr 
545                 550                 555                 560 


Phe Gln Lys Asp Ala Tyr Val Gly Ala Leu Arg Glu Asn Glu Pro Ser 
                565                 570                 575     


Val Thr Gln Leu Val Arg Leu Arg Ala Thr Asp Glu Asp Ser Pro Pro 
            580                 585                 590         


Asn Asn Gln Ile Thr Tyr Ser Ile Val Ser Ala Ser Ala Phe Gly Ser 
        595                 600                 605             


Tyr Phe Asp Ile Ser Leu Tyr Glu Gly Tyr Gly Val Ile Ser Val Ser 
    610                 615                 620                 


Arg Pro Leu Asp Tyr Glu Gln Ile Ser Asn Gly Leu Ile Tyr Leu Thr 
625                 630                 635                 640 


Val Met Ala Met Asp Ala Gly Asn Pro Pro Leu Asn Ser Thr Val Pro 
                645                 650                 655     


Val Thr Ile Glu Val Phe Asp Glu Asn Asp Asn Pro Pro Thr Phe Ser 
            660                 665                 670         


Lys Pro Ala Tyr Phe Val Ser Val Val Glu Asn Ile Met Ala Gly Ala 
        675                 680                 685             


Thr Val Leu Phe Leu Asn Ala Thr Asp Leu Asp Arg Ser Arg Glu Tyr 
    690                 695                 700                 


Gly Gln Glu Ser Ile Ile Tyr Ser Leu Glu Gly Ser Thr Gln Phe Arg 
705                 710                 715                 720 


Ile Asn Ala Arg Ser Gly Glu Ile Thr Thr Thr Ser Leu Leu Asp Arg 
                725                 730                 735     


Glu Thr Lys Ser Glu Tyr Ile Leu Ile Val Arg Ala Val Asp Gly Gly 
            740                 745                 750         


Val Gly His Asn Gln Lys Thr Gly Ile Ala Thr Val Asn Ile Thr Leu 
        755                 760                 765             


Leu Asp Ile Asn Asp Asn His Pro Thr Trp Lys Asp Ala Pro Tyr Tyr 
    770                 775                 780                 


Ile Asn Leu Val Glu Met Thr Pro Pro Asp Ser Asp Val Thr Thr Val 
785                 790                 795                 800 


Val Ala Val Asp Pro Asp Leu Gly Glu Asn Gly Thr Leu Val Tyr Ser 
                805                 810                 815     


Ile Gln Pro Pro Asn Lys Phe Tyr Ser Leu Asn Ser Thr Thr Gly Lys 
            820                 825                 830         


Ile Arg Thr Thr His Ala Met Leu Asp Arg Glu Asn Pro Asp Pro His 
        835                 840                 845             


Glu Ala Glu Leu Met Arg Lys Ile Val Val Ser Val Thr Asp Cys Gly 
    850                 855                 860                 


Arg Pro Pro Leu Lys Ala Thr Ser Ser Ala Thr Val Phe Val Asn Leu 
865                 870                 875                 880 


Leu Asp Leu Asn Asp Asn Asp Pro Thr Phe Gln Asn Leu Pro Phe Val 
                885                 890                 895     


Ala Glu Val Leu Glu Gly Ile Pro Ala Gly Val Ser Ile Tyr Gln Val 
            900                 905                 910         


Val Ala Ile Asp Leu Asp Glu Gly Leu Asn Gly Leu Val Ser Tyr Arg 
        915                 920                 925             


Met Pro Val Gly Met Pro Arg Met Asp Phe Leu Ile Asn Ser Ser Ser 
    930                 935                 940                 


Gly Val Val Val Thr Thr Thr Glu Leu Asp Arg Glu Arg Ile Ala Glu 
945                 950                 955                 960 


Tyr Gln Leu Arg Val Val Ala Ser Asp Ala Gly Thr Pro Thr Lys Ser 
                965                 970                 975     


Ser Thr Ser Thr Leu Thr Ile His Val Leu Asp Val Asn Asp Glu Thr 
            980                 985                 990         


Pro Thr Phe Phe Pro Ala Val Tyr  Asn Val Ser Val Ser  Glu Asp Val 
        995                 1000                 1005             


Pro Arg  Glu Phe Arg Val Val  Trp Leu Asn Cys Thr  Asp Asn Asp 
    1010                 1015                 1020             


Val Gly  Leu Asn Ala Glu Leu  Ser Tyr Phe Ile Thr  Gly Ala Ala 
    1025                 1030                 1035             


Pro Ala  Ser Ala His Leu Cys  Arg Pro Pro Gly Ala  Leu Pro Pro 
    1040                 1045                 1050             


Pro Leu  Pro Asp Gly Gln Pro  Asp 
    1055                 1060     


<210>  2293
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  2293

Met Gly Arg His Val Ala Thr Ser Cys His Val Ala Trp Leu Leu Val 
1               5                   10                  15      


Leu Ile Ser Gly Cys Trp Gly Gln Val Asn Arg Leu Pro Phe Phe Thr 
            20                  25                  30          


Asn His Phe Phe Asp Thr Tyr Leu Leu Ile Ser Glu Asp Thr Pro Val 
        35                  40                  45              


Gly Ser Ser Val Thr Gln Leu Leu Ala Gln Asp Met Asp Asn Asp Pro 
    50                  55                  60                  


Leu Val Phe Gly Val Ser Gly Glu Glu Ala Ser Arg Phe Phe Ala Val 
65                  70                  75                  80  


Glu Pro Asp Thr Gly Val Val Trp Leu Arg Gln Pro Leu Asp Arg Glu 
                85                  90                  95      


Thr Lys Ser Glu Phe Thr Val Glu Phe Ser Val Ser Asp His Gln Gly 
            100                 105                 110         


Val Ile Thr Arg Lys Val Asn Ile Gln Val Gly Asp Val Asn Asp Asn 
        115                 120                 125             


Ala Pro Thr Phe His Asn Gln Pro Tyr Ser Val Arg Ile Pro Glu Asn 
    130                 135                 140                 


Thr Pro Val Gly Thr Pro Ile Phe Ile Val Asn Ala Thr Asp Pro Asp 
145                 150                 155                 160 


Leu Gly Ala Gly Gly Ser Val Leu Tyr Ser Phe Gln Pro Pro Ser Gln 
                165                 170                 175     


Phe Phe Ala Ile Asp Ser Ala Arg Gly Ile Val Thr Val Ile Arg Glu 
            180                 185                 190         


Leu Asp Tyr Glu Thr Thr Gln Ala Tyr Gln Leu Thr Val Asn Ala Thr 
        195                 200                 205             


Asp Gln Asp Lys Thr Arg Pro Leu Ser Thr Leu Ala Asn Leu Ala Ile 
    210                 215                 220                 


Ile Ile Thr Asp Val Gln Asp Met Asp Pro Ile Phe Ile Asn Leu Pro 
225                 230                 235                 240 


Tyr Ser Thr Asn Ile Tyr Glu His Ser Pro Pro Gly Thr Thr Val Arg 
                245                 250                 255     


Ile Ile Thr Ala Ile Asp Gln Asp Lys Gly Arg Pro Arg Gly Ile Gly 
            260                 265                 270         


Tyr Thr Ile Val Ser Gly Asn Thr Asn Ser Ile Phe Ala Leu Asp Tyr 
        275                 280                 285             


Ile Ser Gly Val Leu Thr Leu Asn Gly Leu Leu Asp Arg Glu Asn Pro 
    290                 295                 300                 


Leu Tyr Ser His Gly Phe Ile Leu Thr Val Lys Gly Thr Glu Leu Asn 
305                 310                 315                 320 


Asp Asp Arg Thr Pro Ser Asp Ala Thr Val Thr Thr Thr Phe Asn Ile 
                325                 330                 335     


Leu Val Ile Asp Ile Asn Asp Asn Ala Pro Glu Phe Asn Ser Ser Glu 
            340                 345                 350         


Tyr Ser Val Ala Ile Thr Glu Leu Ala Gln Val Gly Phe Ala Leu Pro 
        355                 360                 365             


Leu Phe Ile Gln Val Val Asp Lys Asp Glu Val Ser Pro Trp Thr His 
    370                 375                 380                 


Gly Pro Cys Arg Pro Thr Thr His Pro Asp Pro Pro Pro Cys Leu Gly 
385                 390                 395                 400 


Cys Ser Gly Pro Gln Leu 
                405     


<210>  2294
<211>  1114
<212>  PRT
<213>  Homo sapiens

<400>  2294

Met Val Lys Ser Pro Met Asn Arg Glu Leu Val Ala Thr Tyr Glu Val 
1               5                   10                  15      


Thr Leu Ser Val Ile Asp Asn Ala Ser Asp Leu Pro Glu Arg Ser Val 
            20                  25                  30          


Ser Val Pro Asn Ala Lys Leu Thr Val Asn Val Leu Asp Val Asn Asp 
        35                  40                  45              


Asn Thr Pro Gln Phe Lys Pro Phe Gly Ile Thr Tyr Tyr Met Glu Arg 
    50                  55                  60                  


Ile Leu Glu Gly Ala Thr Pro Gly Thr Thr Leu Ile Ala Val Ala Ala 
65                  70                  75                  80  


Val Asp Pro Asp Lys Gly Leu Asn Gly Leu Val Thr Tyr Thr Leu Leu 
                85                  90                  95      


Asp Leu Val Pro Pro Gly Tyr Val Gln Leu Glu Asp Ser Ser Ala Gly 
            100                 105                 110         


Lys Val Ile Ala Asn Arg Thr Val Asp Tyr Glu Glu Val His Trp Leu 
        115                 120                 125             


Asn Phe Thr Val Arg Ala Ser Asp Asn Gly Ser Pro Pro Arg Ala Ala 
    130                 135                 140                 


Glu Ile Pro Val Tyr Leu Glu Ile Val Asp Ile Asn Asp Asn Asn Pro 
145                 150                 155                 160 


Ile Phe Asp Gln Pro Ser Tyr Gln Glu Ala Val Phe Glu Asp Val Pro 
                165                 170                 175     


Val Gly Thr Ile Ile Leu Thr Val Thr Ala Thr Asp Ala Asp Ser Gly 
            180                 185                 190         


Asn Phe Ala Leu Ile Glu Tyr Ser Leu Gly Asp Gly Glu Ser Lys Phe 
        195                 200                 205             


Ala Ile Asn Pro Thr Thr Gly Asp Ile Tyr Val Leu Ser Ser Leu Asp 
    210                 215                 220                 


Arg Glu Lys Lys Asp His Tyr Ile Leu Thr Ala Leu Ala Lys Asp Asn 
225                 230                 235                 240 


Pro Gly Asp Val Ala Ser Asn Arg Arg Glu Asn Ser Val Gln Val Val 
                245                 250                 255     


Ile Gln Val Leu Asp Val Asn Asp Cys Arg Pro Gln Phe Ser Lys Pro 
            260                 265                 270         


Gln Phe Ser Thr Ser Val Tyr Glu Asn Glu Pro Ala Gly Thr Ser Val 
        275                 280                 285             


Ile Thr Met Met Ala Thr Asp Gln Asp Glu Gly Pro Asn Gly Glu Leu 
    290                 295                 300                 


Thr Tyr Ser Leu Glu Gly Pro Gly Val Glu Ala Phe His Val Asp Met 
305                 310                 315                 320 


Asp Ser Gly Leu Val Thr Thr Gln Arg Pro Leu Gln Ser Tyr Glu Lys 
                325                 330                 335     


Phe Ser Leu Thr Val Val Ala Thr Asp Gly Gly Glu Pro Pro Leu Trp 
            340                 345                 350         


Gly Thr Thr Met Leu Leu Val Glu Val Ile Asp Val Asn Asp Asn Arg 
        355                 360                 365             


Pro Val Phe Val Arg Pro Pro Asn Gly Thr Ile Leu His Ile Arg Glu 
    370                 375                 380                 


Glu Ile Pro Leu Arg Ser Asn Val Tyr Glu Val Tyr Ala Thr Asp Lys 
385                 390                 395                 400 


Asp Glu Gly Leu Asn Gly Ala Val Arg Tyr Ser Phe Leu Lys Thr Ala 
                405                 410                 415     


Gly Asn Arg Asp Trp Glu Phe Phe Ile Ile Asp Pro Ile Ser Gly Leu 
            420                 425                 430         


Ile Gln Thr Ala Gln Arg Leu Asp Arg Glu Ser Gln Ala Val Tyr Ser 
        435                 440                 445             


Leu Ile Leu Val Ala Ser Asp Leu Gly Gln Pro Val Pro Tyr Glu Thr 
    450                 455                 460                 


Met Gln Pro Leu Gln Val Ala Leu Glu Asp Ile Asp Asp Asn Glu Pro 
465                 470                 475                 480 


Leu Phe Val Arg Pro Pro Lys Gly Ser Pro Gln Tyr Gln Leu Leu Thr 
                485                 490                 495     


Val Pro Glu His Ser Pro Arg Gly Thr Leu Val Gly Asn Val Thr Gly 
            500                 505                 510         


Ala Val Asp Ala Asp Glu Gly Pro Asn Ala Ile Val Tyr Tyr Phe Ile 
        515                 520                 525             


Ala Ala Gly Asn Glu Glu Lys Asn Phe His Leu Gln Pro Asp Gly Cys 
    530                 535                 540                 


Leu Leu Val Leu Arg Asp Leu Asp Arg Glu Arg Glu Ala Ile Phe Ser 
545                 550                 555                 560 


Phe Ile Val Lys Ala Ser Ser Asn Arg Ser Trp Thr Pro Pro Arg Gly 
                565                 570                 575     


Pro Ser Pro Thr Leu Asp Leu Val Ala Asp Leu Thr Leu Gln Glu Val 
            580                 585                 590         


Arg Val Val Leu Glu Asp Ile Asn Asp Gln Pro Pro Arg Phe Thr Lys 
        595                 600                 605             


Ala Glu Tyr Thr Ala Gly Val Ala Thr Asp Ala Lys Val Gly Ser Glu 
    610                 615                 620                 


Leu Ile Gln Val Leu Ala Leu Asp Ala Asp Ile Gly Asn Asn Ser Leu 
625                 630                 635                 640 


Val Phe Tyr Ser Ile Leu Ala Ile His Tyr Phe Arg Ala Leu Ala Asn 
                645                 650                 655     


Asp Ser Glu Asp Val Gly Gln Val Phe Thr Met Gly Ser Met Asp Gly 
            660                 665                 670         


Ile Leu Arg Thr Phe Asp Leu Phe Met Ala Tyr Ser Pro Gly Tyr Phe 
        675                 680                 685             


Val Val Asp Ile Val Ala Arg Asp Leu Ala Gly His Asn Asp Thr Ala 
    690                 695                 700                 


Ile Ile Gly Ile Tyr Ile Leu Arg Asp Asp Gln Arg Val Lys Ile Val 
705                 710                 715                 720 


Ile Asn Glu Ile Pro Asp Arg Val Arg Gly Phe Glu Glu Glu Phe Ile 
                725                 730                 735     


His Leu Leu Ser Asn Ile Thr Gly Ala Ile Val Asn Thr Asp Asn Val 
            740                 745                 750         


Gln Phe His Val Asp Lys Lys Gly Arg Val Asn Phe Ala Gln Thr Glu 
        755                 760                 765             


Leu Leu Ile His Val Val Asn Arg Asp Thr Asn Arg Ile Leu Asp Val 
    770                 775                 780                 


Asp Arg Val Ile Gln Met Ile Asp Glu Asn Lys Glu Gln Leu Arg Asn 
785                 790                 795                 800 


Leu Phe Arg Asn Tyr Asn Val Leu Asp Val Gln Pro Ala Ile Ser Val 
                805                 810                 815     


Arg Leu Pro Asp Asp Met Ser Ala Leu Gln Met Ala Ile Ile Val Leu 
            820                 825                 830         


Ala Ile Leu Leu Phe Leu Ala Ala Met Leu Phe Val Leu Met Asn Trp 
        835                 840                 845             


Tyr Tyr Arg Thr Val His Lys Arg Lys Leu Lys Ala Ile Val Ala Gly 
    850                 855                 860                 


Ser Ala Gly Asn Arg Gly Phe Ile Asp Ile Met Asp Met Pro Asn Thr 
865                 870                 875                 880 


Asn Lys Tyr Ser Phe Asp Gly Ala Asn Pro Val Trp Leu Asp Pro Phe 
                885                 890                 895     


Cys Arg Asn Leu Glu Leu Ala Ala Gln Ala Glu His Glu Asp Asp Leu 
            900                 905                 910         


Pro Glu Asn Leu Ser Glu Ile Ala Asp Leu Trp Asn Ser Pro Thr Arg 
        915                 920                 925             


Thr His Gly Thr Phe Gly Arg Glu Pro Ala Ala Val Lys Pro Asp Asp 
    930                 935                 940                 


Asp Arg Tyr Leu Arg Ala Ala Ile Gln Glu Tyr Asp Asn Ile Ala Lys 
945                 950                 955                 960 


Leu Gly Gln Ile Ile Arg Glu Gly Pro Ile Lys Gly Ser Leu Leu Lys 
                965                 970                 975     


Val Val Leu Glu Asp Tyr Leu Arg Leu Lys Lys Leu Phe Ala Gln Arg 
            980                 985                 990         


Met Val Gln Lys Ala Ser Ser Cys  His Ser Ser Ile Ser  Glu Leu Ile 
        995                 1000                 1005             


Gln Thr  Glu Leu Asp Glu Glu  Pro Gly Asp His Ser  Pro Gly Gln 
    1010                 1015                 1020             


Gly Ser  Leu Arg Phe Arg His  Lys Pro Pro Val Glu  Leu Lys Gly 
    1025                 1030                 1035             


Pro Asp  Gly Ile His Val Val  His Gly Ser Thr Gly  Thr Leu Leu 
    1040                 1045                 1050             


Ala Thr  Asp Leu Asn Ser Leu  Pro Glu Glu Asp Gln  Lys Gly Leu 
    1055                 1060                 1065             


Gly Arg  Ser Leu Glu Thr Leu  Thr Ala Ala Glu Ala  Thr Ala Phe 
    1070                 1075                 1080             


Glu Arg  Asn Ala Arg Thr Glu  Ser Ala Lys Ser Thr  Pro Leu His 
    1085                 1090                 1095             


Lys Leu  Arg Asp Val Ile Met  Glu Thr Pro Leu Glu  Ile Thr Glu 
    1100                 1105                 1110             


Leu 
    


<210>  2295
<211>  1079
<212>  PRT
<213>  Homo sapiens

<400>  2295

Met Val Lys Ser Pro Met Asn Arg Glu Leu Val Ala Thr Tyr Glu Val 
1               5                   10                  15      


Thr Leu Ser Val Ile Asp Asn Ala Ser Asp Leu Pro Glu Arg Ser Val 
            20                  25                  30          


Ser Val Pro Asn Ala Lys Leu Thr Val Asn Val Leu Asp Val Asn Asp 
        35                  40                  45              


Asn Thr Pro Gln Phe Lys Pro Phe Gly Ile Thr Tyr Tyr Met Glu Arg 
    50                  55                  60                  


Ile Leu Glu Gly Ala Thr Pro Gly Thr Thr Leu Ile Ala Val Ala Ala 
65                  70                  75                  80  


Val Asp Pro Asp Lys Gly Leu Asn Gly Leu Val Thr Tyr Thr Leu Leu 
                85                  90                  95      


Asp Leu Val Pro Pro Gly Tyr Val Gln Leu Glu Asp Ser Ser Ala Gly 
            100                 105                 110         


Lys Val Ile Ala Asn Arg Thr Val Asp Tyr Glu Glu Val His Trp Leu 
        115                 120                 125             


Asn Phe Thr Val Arg Ala Ser Asp Asn Gly Ser Pro Pro Arg Ala Ala 
    130                 135                 140                 


Glu Ile Pro Val Tyr Leu Glu Ile Val Asp Ile Asn Asp Asn Asn Pro 
145                 150                 155                 160 


Ile Phe Asp Gln Pro Ser Tyr Gln Glu Ala Val Phe Glu Asp Val Pro 
                165                 170                 175     


Val Gly Thr Ile Ile Leu Thr Val Thr Ala Thr Asp Ala Asp Ser Gly 
            180                 185                 190         


Asn Phe Ala Leu Ile Glu Tyr Ser Leu Gly Asp Gly Glu Ser Lys Phe 
        195                 200                 205             


Ala Ile Asn Pro Thr Thr Gly Asp Ile Tyr Val Leu Ser Ser Leu Asp 
    210                 215                 220                 


Arg Glu Lys Lys Asp His Tyr Ile Leu Thr Ala Leu Ala Lys Asp Asn 
225                 230                 235                 240 


Pro Gly Asp Val Ala Ser Asn Arg Arg Glu Asn Ser Val Gln Val Val 
                245                 250                 255     


Ile Gln Val Leu Asp Val Asn Asp Cys Arg Pro Gln Phe Ser Lys Pro 
            260                 265                 270         


Gln Phe Ser Thr Ser Val Tyr Glu Asn Glu Pro Ala Gly Thr Ser Val 
        275                 280                 285             


Ile Thr Met Met Ala Thr Asp Gln Asp Glu Gly Pro Asn Gly Glu Leu 
    290                 295                 300                 


Thr Tyr Ser Leu Glu Gly Pro Gly Val Glu Ala Phe His Val Asp Met 
305                 310                 315                 320 


Asp Ser Gly Leu Val Thr Thr Gln Arg Pro Leu Gln Ser Tyr Glu Lys 
                325                 330                 335     


Phe Ser Leu Thr Val Val Ala Thr Asp Gly Gly Glu Pro Pro Leu Trp 
            340                 345                 350         


Gly Thr Thr Met Leu Leu Val Glu Val Ile Asp Val Asn Asp Asn Arg 
        355                 360                 365             


Pro Val Phe Val Arg Pro Pro Asn Gly Thr Ile Leu His Ile Arg Glu 
    370                 375                 380                 


Glu Ile Pro Leu Arg Ser Asn Val Tyr Glu Val Tyr Ala Thr Asp Lys 
385                 390                 395                 400 


Asp Glu Gly Leu Asn Gly Ala Val Arg Tyr Ser Phe Leu Lys Thr Ala 
                405                 410                 415     


Gly Asn Arg Asp Trp Glu Phe Phe Ile Ile Asp Pro Ile Ser Gly Leu 
            420                 425                 430         


Ile Gln Thr Ala Gln Arg Leu Asp Arg Glu Ser Gln Ala Val Tyr Ser 
        435                 440                 445             


Leu Ile Leu Val Ala Ser Asp Leu Gly Gln Pro Val Pro Tyr Glu Thr 
    450                 455                 460                 


Met Gln Pro Leu Gln Val Ala Leu Glu Asp Ile Asp Asp Asn Glu Pro 
465                 470                 475                 480 


Leu Phe Val Arg Pro Pro Lys Gly Ser Pro Gln Tyr Gln Leu Leu Thr 
                485                 490                 495     


Val Pro Glu His Ser Pro Arg Gly Thr Leu Val Gly Asn Val Thr Gly 
            500                 505                 510         


Ala Val Asp Ala Asp Glu Gly Pro Asn Ala Ile Val Tyr Tyr Phe Ile 
        515                 520                 525             


Ala Ala Gly Asn Glu Glu Lys Asn Phe His Leu Gln Pro Asp Gly Cys 
    530                 535                 540                 


Leu Leu Val Leu Arg Asp Leu Asp Arg Glu Arg Glu Ala Ile Phe Ser 
545                 550                 555                 560 


Phe Ile Val Lys Ala Ser Ser Asn Arg Ser Trp Thr Pro Pro Arg Gly 
                565                 570                 575     


Pro Ser Pro Thr Leu Asp Leu Val Ala Asp Leu Thr Leu Gln Glu Val 
            580                 585                 590         


Arg Val Val Leu Glu Asp Ile Asn Asp Gln Pro Pro Arg Phe Thr Lys 
        595                 600                 605             


Ala Glu Tyr Thr Ala Gly Val Ala Thr Asp Ala Lys Val Gly Ser Glu 
    610                 615                 620                 


Leu Ile Gln Val Leu Ala Leu Asp Ala Asp Ile Gly Asn Asn Ser Leu 
625                 630                 635                 640 


Val Phe Tyr Ser Ile Leu Ala Ile His Tyr Phe Arg Ala Leu Ala Asn 
                645                 650                 655     


Asp Ser Glu Asp Val Gly Gln Val Phe Thr Met Gly Ser Met Asp Gly 
            660                 665                 670         


Ile Leu Arg Thr Phe Asp Leu Phe Met Ala Tyr Ser Pro Gly Tyr Phe 
        675                 680                 685             


Val Val Asp Ile Val Ala Arg Asp Leu Ala Gly His Asn Asp Thr Ala 
    690                 695                 700                 


Ile Ile Gly Ile Tyr Ile Leu Arg Asp Asp Gln Arg Val Lys Ile Val 
705                 710                 715                 720 


Ile Asn Glu Ile Pro Asp Arg Val Arg Gly Phe Glu Glu Glu Phe Ile 
                725                 730                 735     


His Leu Leu Ser Asn Ile Thr Gly Ala Ile Val Asn Thr Asp Asn Val 
            740                 745                 750         


Gln Phe His Val Asp Lys Lys Gly Arg Val Asn Phe Ala Gln Thr Glu 
        755                 760                 765             


Leu Leu Ile His Val Val Asn Arg Asp Thr Asn Arg Ile Leu Asp Val 
    770                 775                 780                 


Asp Arg Val Ile Gln Met Ile Asp Glu Asn Lys Glu Gln Leu Arg Asn 
785                 790                 795                 800 


Leu Phe Arg Asn Tyr Asn Val Leu Asp Val Gln Pro Ala Ile Ser Val 
                805                 810                 815     


Arg Leu Pro Asp Asp Met Ser Ala Leu Gln Met Ala Ile Ile Val Leu 
            820                 825                 830         


Ala Ile Leu Leu Phe Leu Ala Ala Met Leu Phe Val Leu Met Asn Trp 
        835                 840                 845             


Tyr Tyr Arg Thr Val His Lys Arg Lys Leu Lys Ala Ile Val Ala Gly 
    850                 855                 860                 


Ser Ala Gly Asn Arg Gly Phe Ile Asp Ile Met Asp Met Pro Asn Thr 
865                 870                 875                 880 


Asn Lys Tyr Ser Phe Asp Gly Ala Asn Pro Val Trp Leu Asp Pro Phe 
                885                 890                 895     


Cys Arg Asn Leu Glu Leu Ala Ala Gln Ala Glu His Glu Asp Asp Leu 
            900                 905                 910         


Pro Glu Asn Leu Ser Glu Ile Ala Asp Leu Trp Asn Ser Pro Thr Arg 
        915                 920                 925             


Thr His Gly Thr Phe Gly Arg Glu Pro Ala Ala Val Lys Pro Asp Asp 
    930                 935                 940                 


Asp Arg Tyr Leu Arg Ala Ala Ile Gln Glu Tyr Asp Asn Ile Ala Lys 
945                 950                 955                 960 


Leu Gly Gln Ile Ile Arg Glu Gly Pro Ile Lys Leu Ile Gln Thr Glu 
                965                 970                 975     


Leu Asp Glu Glu Pro Gly Asp His Ser Pro Gly Gln Gly Ser Leu Arg 
            980                 985                 990         


Phe Arg His Lys Pro Pro Val Glu  Leu Lys Gly Pro Asp  Gly Ile His 
        995                 1000                 1005             


Val Val  His Gly Ser Thr Gly  Thr Leu Leu Ala Thr  Asp Leu Asn 
    1010                 1015                 1020             


Ser Leu  Pro Glu Glu Asp Gln  Lys Gly Leu Gly Arg  Ser Leu Glu 
    1025                 1030                 1035             


Thr Leu  Thr Ala Ala Glu Ala  Thr Ala Phe Glu Arg  Asn Ala Arg 
    1040                 1045                 1050             


Thr Glu  Ser Ala Lys Ser Thr  Pro Leu His Lys Leu  Arg Asp Val 
    1055                 1060                 1065             


Ile Met  Glu Thr Pro Leu Glu  Ile Thr Glu Leu 
    1070                 1075                 


<210>  2296
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  2296

Met Arg Ser Trp Phe Gln Gln Asp Pro Met Val Gly Ala Cys Thr Thr 
1               5                   10                  15      


Gly Thr Arg Ala Ser His Pro Lys Ala Asn Pro Val Trp Leu Asp Pro 
            20                  25                  30          


Phe Cys Arg Asn Leu Glu Leu Ala Ala Gln Ala Glu His Glu Asp Asp 
        35                  40                  45              


Leu Pro Glu Asn Leu Ser Glu Ile Ala Asp Leu Trp Asn Ser Pro Thr 
    50                  55                  60                  


Arg Thr His Gly Thr Phe Gly Arg Glu Pro Ala Ala Val Lys Pro Asp 
65                  70                  75                  80  


Asp Asp Arg Tyr Leu Arg Ala Ala Ile Gln Glu Tyr Asp Asn Ile Ala 
                85                  90                  95      


Lys Leu Gly Gln Ile Ile Arg Glu Gly Pro Ile Lys Gly Ser Leu Leu 
            100                 105                 110         


Lys Val Val Leu Glu Asp Tyr Leu Arg Leu Lys Lys Leu Phe Ala Gln 
        115                 120                 125             


Arg Met Val Gln Lys Ala Ser Ser Cys His Ser Ser Ile Ser Glu Leu 
    130                 135                 140                 


Ile Gln Thr Glu Leu Asp Glu Glu Pro Gly Asp His Ser Pro Gly Gln 
145                 150                 155                 160 


Gly Ser Leu Arg Phe Arg His Lys Pro Pro Val Glu Leu Lys Gly Pro 
                165                 170                 175     


Asp Gly Ile His Val Val His Gly Ser Thr Gly Thr Leu Leu Ala Thr 
            180                 185                 190         


Asp Leu Asn Ser Leu Pro Glu Glu Asp Gln Lys Gly Leu Gly Arg Ser 
        195                 200                 205             


Leu Glu Thr Leu Thr Ala Ala Glu Ala Thr Ala Phe Glu Arg Asn Ala 
    210                 215                 220                 


Arg Thr Glu Ser Ala Lys Ser Thr Pro Leu His Lys Leu Arg Asp Val 
225                 230                 235                 240 


Ile Met Glu Thr Pro Leu Glu Ile Thr Glu Leu 
                245                 250     


<210>  2297
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  2297

Met Arg Ser Trp Phe Gln Gln Asp Pro Met Val Gly Ala Cys Thr Thr 
1               5                   10                  15      


Gly Thr Arg Ala Ser His Pro Lys Ala Asn Pro Val Trp Leu Asp Pro 
            20                  25                  30          


Phe Cys Arg Asn Leu Glu Leu Ala Ala Gln Ala Glu His Glu Asp Asp 
        35                  40                  45              


Leu Pro Glu Asn Leu Ser Glu Ile Ala Asp Leu Trp Asn Ser Pro Thr 
    50                  55                  60                  


Arg Thr His Gly Thr Phe Gly Arg Glu Pro Ala Ala Val Lys Pro Asp 
65                  70                  75                  80  


Asp Asp Arg Tyr Leu Arg Ala Ala Ile Gln Glu Tyr Asp Asn Ile Ala 
                85                  90                  95      


Lys Leu Gly Gln Ile Ile Arg Glu Gly Pro Ile Lys Leu Ile Gln Thr 
            100                 105                 110         


Glu Leu Asp Glu Glu Pro Gly Asp His Ser Pro Gly Gln Gly Ser Leu 
        115                 120                 125             


Arg Phe Arg His Lys Pro Pro Val Glu Leu Lys Gly Pro Asp Gly Ile 
    130                 135                 140                 


His Val Val His Gly Ser Thr Gly Thr Leu Leu Ala Thr Asp Leu Asn 
145                 150                 155                 160 


Ser Leu Pro Glu Glu Asp Gln Lys Gly Leu Gly Arg Ser Leu Glu Thr 
                165                 170                 175     


Leu Thr Ala Ala Glu Ala Thr Ala Phe Glu Arg Asn Ala Arg Thr Glu 
            180                 185                 190         


Ser Ala Lys Ser Thr Pro Leu His Lys Leu Arg Asp Val Ile Met Glu 
        195                 200                 205             


Thr Pro Leu Glu Ile Thr Glu Leu 
    210                 215     


<210>  2298
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  2298

Met His Pro Gly Ser Pro Ser Ala Trp Pro Pro Arg Ala Arg Ala Ala 
1               5                   10                  15      


Leu Arg Leu Trp Leu Gly Cys Val Cys Phe Ala Leu Val Gln Ala Asp 
            20                  25                  30          


Ser Pro Ser Ala Pro Val Asn Val Thr Val Arg His Leu Lys Ala Asn 
        35                  40                  45              


Ser Ala Val Val Ser Trp Asp Val Leu Glu Asp Glu Val Val Ile Gly 
    50                  55                  60                  


Phe Ala Ile Ser Gln Gln Lys Lys Asp Val Arg Met Leu Arg Phe Ile 
65                  70                  75                  80  


Gln Glu Val Asn Thr Thr Thr Arg Ser Cys Ala Leu Trp Asp Leu Glu 
                85                  90                  95      


Glu Asp Thr Glu Tyr Ile Val His Val Gln Ala Ile Ser Ile Gln Gly 
            100                 105                 110         


Gln Ser Pro Ala Ser Glu Pro Val Leu Phe Lys Thr Pro Arg Glu Ala 
        115                 120                 125             


Glu Lys Met Ala Ser Lys Asn Lys Asp Glu Val Thr Met Lys Glu Met 
    130                 135                 140                 


Gly Arg Asn Gln Gln Leu Arg Thr Gly Glu Val Leu Ile Ile Val Val 
145                 150                 155                 160 


Val Leu Phe Met Trp Ala Gly Val Ile Ala Leu Phe Cys Arg Gln Tyr 
                165                 170                 175     


Asp Ile Ile Glu Ala 
            180     


<210>  2299
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  2299

Met Leu Arg Phe Ile Gln Glu Val Asn Thr Thr Thr Arg Ser Cys Ala 
1               5                   10                  15      


Leu Trp Asp Leu Glu Glu Asp Thr Glu Tyr Ile Val His Val Gln Ala 
            20                  25                  30          


Ile Ser Ile Gln Gly Gln Ser Pro Ala Ser Glu Pro Val Leu Phe Lys 
        35                  40                  45              


Thr Pro Arg Glu Ala Glu Lys Met Ala Ser Lys Asn Lys Asp Glu Val 
    50                  55                  60                  


Thr Met Lys Glu Met Gly Arg Asn Gln Gln Leu Arg Thr Gly Glu Val 
65                  70                  75                  80  


Leu Ile Ile Val Val Val Leu Phe Met Trp Ala Gly Val Ile Ala Leu 
                85                  90                  95      


Phe Cys Arg Gln Tyr Asp Ile Ile Lys Asp Asn Glu Pro Asn Asn Asn 
            100                 105                 110         


Lys Glu Lys Thr Lys Ser Ala Ser Glu Thr Ser Thr Pro Glu His Gln 
        115                 120                 125             


Gly Gly Gly Leu Leu Arg Ser Lys Val Arg Ala Arg Pro Gly Pro Gly 
    130                 135                 140                 


Trp Ala Thr Leu Cys Leu Met Leu Trp 
145                 150             


<210>  2300
<211>  363
<212>  PRT
<213>  Homo sapiens

<400>  2300

Met Asp Tyr Arg Val Asn Ile Phe Leu Arg Gln Gln Trp Asn Asp Ser 
1               5                   10                  15      


Arg Leu Ala Tyr Ser Glu Tyr Pro Asp Asp Ser Leu Asp Leu Asp Pro 
            20                  25                  30          


Ser Met Leu Asp Ser Ile Trp Lys Pro Asp Leu Phe Phe Ala Asn Glu 
        35                  40                  45              


Lys Gly Ala Asn Phe His Asp Val Thr Thr Asp Asn Lys Leu Leu Arg 
    50                  55                  60                  


Ile Ser Lys Asn Gly Lys Val Leu Tyr Ser Ile Arg Leu Thr Leu Thr 
65                  70                  75                  80  


Leu Ser Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp Val Gln Thr 
                85                  90                  95      


Cys Thr Met Gln Leu Glu Ser Phe Gly Tyr Thr Met Asn Asp Leu Ile 
            100                 105                 110         


Phe Glu Trp Leu Ser Asp Gly Pro Val Gln Val Ala Glu Gly Leu Thr 
        115                 120                 125             


Leu Pro Gln Phe Ile Leu Lys Glu Glu Lys Glu Leu Gly Tyr Cys Thr 
    130                 135                 140                 


Lys His Tyr Asn Thr Gly Lys Phe Thr Cys Ile Glu Val Lys Phe His 
145                 150                 155                 160 


Leu Glu Arg Gln Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro Ser 
                165                 170                 175     


Leu Leu Ile Val Ile Leu Ser Trp Val Ser Phe Trp Ile Asn Met Asp 
            180                 185                 190         


Ala Ala Pro Ala Arg Val Ala Leu Gly Ile Thr Thr Val Leu Thr Met 
        195                 200                 205             


Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser Tyr 
    210                 215                 220                 


Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val Phe 
225                 230                 235                 240 


Ala Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln His 
                245                 250                 255     


Lys Glu Phe Leu Arg Leu Arg Arg Arg Gln Lys Arg Gln Asn Lys Glu 
            260                 265                 270         


Glu Asp Val Thr Arg Glu Ser Arg Phe Asn Phe Ser Gly Tyr Gly Met 
        275                 280                 285             


Gly His Cys Leu Gln Val Lys Asp Gly Thr Ala Val Lys Ala Thr Pro 
    290                 295                 300                 


Ala Asn Pro Leu Pro Gln Pro Pro Lys Asp Gly Asp Ala Ile Lys Lys 
305                 310                 315                 320 


Lys Phe Val Asp Arg Ala Lys Arg Ile Asp Thr Ile Ser Arg Ala Ala 
                325                 330                 335     


Phe Pro Leu Ala Phe Leu Ile Phe Asn Ile Phe Tyr Trp Ile Thr Tyr 
            340                 345                 350         


Lys Ile Ile Arg His Glu Asp Val His Lys Lys 
        355                 360             


<210>  2301
<211>  682
<212>  PRT
<213>  Homo sapiens

<400>  2301

Met Asp Phe Ser Arg Leu His Met Tyr Ser Pro Pro Gln Cys Val Pro 
1               5                   10                  15      


Glu Asn Thr Gly Tyr Thr Tyr Ala Leu Ser Ser Ser Tyr Ser Ser Asp 
            20                  25                  30          


Ala Leu Asp Phe Glu Thr Glu His Lys Leu Asp Pro Val Phe Asp Ser 
        35                  40                  45              


Pro Arg Met Ser Arg Arg Ser Leu Arg Leu Ala Thr Thr Ala Cys Thr 
    50                  55                  60                  


Leu Gly Asp Gly Glu Ala Val Gly Ala Asp Ser Gly Thr Ser Ser Ala 
65                  70                  75                  80  


Val Ser Leu Lys Asn Arg Ala Ala Arg Thr Thr Lys Gln Arg Arg Ser 
                85                  90                  95      


Thr Asn Lys Ser Ala Phe Ser Ile Asn His Val Ser Arg Gln Val Thr 
            100                 105                 110         


Ser Ser Gly Val Ser His Gly Gly Thr Val Ser Leu Gln Asp Ala Val 
        115                 120                 125             


Thr Arg Arg Pro Pro Val Leu Asp Glu Ser Trp Ile Arg Glu Gln Thr 
    130                 135                 140                 


Thr Val Asp His Phe Trp Gly Lys Ala Ala Ser Gly Val Phe Trp Trp 
145                 150                 155                 160 


Leu Gly Ile Gly Trp Tyr Gln Phe Val Thr Leu Ile Ser Trp Leu Asn 
                165                 170                 175     


Val Phe Leu Leu Thr Arg Cys Leu Arg Asn Ile Cys Lys Phe Leu Val 
            180                 185                 190         


Leu Leu Ile Pro Leu Phe Leu Leu Leu Gly Leu Ser Leu Arg Gly Gln 
        195                 200                 205             


Gly Asn Phe Phe Ser Phe Leu Pro Val Leu Asn Trp Ala Ser Met His 
    210                 215                 220                 


Arg Thr Gln Arg Val Asp Asp Pro Gln Asp Val Phe Lys Pro Thr Thr 
225                 230                 235                 240 


Ser Arg Leu Lys Gln Pro Leu Gln Gly Asp Ser Glu Ala Phe Pro Trp 
                245                 250                 255     


His Trp Met Ser Gly Val Glu Gln Gln Val Ala Ser Leu Ser Gly Gln 
            260                 265                 270         


Cys His His His Gly Glu Asn Leu Arg Glu Leu Thr Thr Leu Leu Gln 
        275                 280                 285             


Lys Leu Gln Ala Arg Val Asp Gln Met Glu Gly Gly Ala Ala Gly Pro 
    290                 295                 300                 


Ser Ala Ser Val Arg Asp Ala Val Gly Gln Pro Pro Arg Glu Thr Asp 
305                 310                 315                 320 


Phe Met Ala Phe His Gln Glu His Glu Val Arg Met Ser His Leu Glu 
                325                 330                 335     


Asp Ile Leu Gly Lys Leu Arg Glu Lys Ser Glu Ala Ile Gln Lys Glu 
            340                 345                 350         


Leu Glu Gln Thr Lys Gln Lys Thr Ile Ser Ala Val Gly Glu Gln Leu 
        355                 360                 365             


Leu Pro Thr Val Glu His Leu Gln Leu Glu Leu Asp Gln Leu Lys Ser 
    370                 375                 380                 


Glu Leu Ser Ser Trp Arg His Val Lys Thr Gly Cys Glu Thr Val Asp 
385                 390                 395                 400 


Ala Val Gln Glu Arg Val Asp Val Gln Val Arg Glu Met Val Lys Leu 
                405                 410                 415     


Leu Phe Ser Glu Asp Gln Gln Gly Gly Ser Leu Glu Gln Leu Leu Gln 
            420                 425                 430         


Arg Phe Ser Ser Gln Phe Val Ser Lys Gly Asp Leu Gln Thr Met Leu 
        435                 440                 445             


Arg Asp Leu Gln Leu Gln Ile Leu Arg Asn Val Thr His His Val Ser 
    450                 455                 460                 


Val Thr Lys Gln Leu Pro Thr Ser Glu Ala Val Val Ser Ala Val Ser 
465                 470                 475                 480 


Glu Ala Gly Ala Ser Gly Ile Thr Glu Ala Gln Ala Arg Ala Ile Val 
                485                 490                 495     


Asn Ser Ala Leu Lys Leu Tyr Ser Gln Asp Lys Thr Gly Met Val Asp 
            500                 505                 510         


Phe Ala Leu Glu Ser Gly Gly Gly Ser Ile Leu Ser Thr Arg Cys Ser 
        515                 520                 525             


Glu Thr Tyr Glu Thr Lys Thr Ala Leu Met Ser Leu Phe Gly Ile Pro 
    530                 535                 540                 


Leu Trp Tyr Phe Ser Gln Ser Pro Arg Val Val Ile Gln Pro Asp Ile 
545                 550                 555                 560 


Tyr Pro Gly Asn Cys Trp Ala Phe Lys Gly Ser Gln Gly Tyr Leu Val 
                565                 570                 575     


Val Arg Leu Ser Met Met Ile His Pro Ala Ala Phe Thr Leu Glu His 
            580                 585                 590         


Ile Pro Lys Thr Leu Ser Pro Thr Gly Asn Ile Ser Ser Ala Pro Lys 
        595                 600                 605             


Asp Phe Ala Val Tyr Gly Leu Glu Asn Glu Tyr Gln Glu Glu Gly Gln 
    610                 615                 620                 


Leu Leu Gly Gln Phe Thr Tyr Asp Gln Asp Gly Glu Ser Leu Gln Met 
625                 630                 635                 640 


Phe Gln Ala Leu Lys Arg Pro Asp Asp Thr Ala Phe Gln Ile Val Glu 
                645                 650                 655     


Leu Arg Ile Phe Ser Asn Trp Gly His Pro Glu Tyr Thr Cys Leu Tyr 
            660                 665                 670         


Arg Phe Arg Val His Gly Glu Pro Val Lys 
        675                 680         


<210>  2302
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  2302

Met Gly Arg Ile Ser Pro Gly Ser Pro Gly Leu Pro Arg Thr Val Trp 
1               5                   10                  15      


Phe Glu Val Val Asn Met Asp Phe Ser Arg Leu His Met Tyr Ser Pro 
            20                  25                  30          


Pro Gln Cys Val Pro Glu Asn Thr Gly Tyr Thr Tyr Ala Leu Ser Ser 
        35                  40                  45              


Ser Tyr Ser Ser Asp Ala Leu Asp Phe Glu Thr Glu His Lys Leu Asp 
    50                  55                  60                  


Pro Val Phe Asp Ser Pro Arg Met Ser Arg Arg Ser Leu Arg Leu Ala 
65                  70                  75                  80  


Thr Thr Ala Cys Thr Leu Gly Asp Gly Glu Ala Val Gly Ala Asp Ser 
                85                  90                  95      


Gly Thr Ser Ser Ala Val Ser Leu Lys Asn Arg Ala Ala Arg Thr Thr 
            100                 105                 110         


Lys Gln Arg Arg Ser Thr Asn Lys Ser Ala Phe Ser Ile Asn His Val 
        115                 120                 125             


Ser Arg Gln Val Thr Ser Ser Gly Val Ser His Gly Gly Thr Val Ser 
    130                 135                 140                 


Leu Gln Asp Ala Val Thr Arg Arg Pro Pro Val Leu Asp Glu Ser Trp 
145                 150                 155                 160 


Ile Arg Glu Gln Thr Thr Val Asp His Phe Trp Gly Leu Asp Asp Asp 
                165                 170                 175     


Gly Asp Leu Lys Gly Gly Asn Lys Ala Ala Ile Gln Gly Asn Gly Asp 
            180                 185                 190         


Val Gly Ala Ala Ala Ala Thr Ala His Asn Gly Phe Ser Cys Ser Asn 
        195                 200                 205             


Cys Ser Met Leu Ser Glu Arg Lys Asp Val Leu Thr Ala His Pro Ala 
    210                 215                 220                 


Ala Pro Gly Pro Val Ser Arg Val Tyr Ser Arg Asp Arg Asn Gln Lys 
225                 230                 235                 240 


Cys Lys Ser Gln Ser Phe Lys Thr Gln Lys Lys Val Cys Phe Pro Asn 
                245                 250                 255     


Leu Ile Phe Pro Phe Cys Lys Ser Gln Cys Leu His Tyr Leu Ser Trp 
            260                 265                 270         


Arg Leu Lys Ile Ile Pro 
        275             


<210>  2303
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  2303

Met Asp Phe Ser Arg Leu His Met Tyr Ser Pro Pro Gln Cys Val Pro 
1               5                   10                  15      


Glu Asn Thr Gly Tyr Thr Tyr Ala Leu Ser Ser Ser Tyr Ser Ser Asp 
            20                  25                  30          


Ala Leu Asp Phe Glu Thr Glu His Lys Leu Asp Pro Val Phe Asp Ser 
        35                  40                  45              


Pro Arg Met Ser Arg Arg Ser Leu Arg Leu Ala Thr Thr Ala Cys Thr 
    50                  55                  60                  


Leu Gly Asp Gly Glu Ala Val Gly Ala Asp Ser Gly Thr Ser Ser Ala 
65                  70                  75                  80  


Val Ser Leu Lys Asn Arg Ala Ala Arg Thr Thr Lys Gln Arg Arg Ser 
                85                  90                  95      


Thr Asn Lys Ser Ala Phe Ser Ile Asn His Val Ser Arg Gln Val Thr 
            100                 105                 110         


Ser Ser Gly Val Ser His Gly Gly Thr Val Ser Leu Gln Asp Ala Val 
        115                 120                 125             


Thr Arg Arg Pro Pro Val Leu Asp Glu Ser Trp Ile Arg Glu Gln Thr 
    130                 135                 140                 


Thr Val Asp His Phe Trp Gly Leu Asp Asp Asp Gly Asp Leu Lys Gly 
145                 150                 155                 160 


Gly Asn Lys Ala Ala Ile Gln Gly Asn Gly Asp Val Gly Ala Ala Ala 
                165                 170                 175     


Ala Thr Ala His Asn Gly Phe Ser Cys Ser Asn Cys Ser Met Leu Ser 
            180                 185                 190         


Glu Arg Lys Asp Val Leu Thr Ala His Pro Ala Ala Pro Gly Pro Val 
        195                 200                 205             


Ser Arg Val Tyr Ser Arg Asp Arg Asn Gln Lys Cys Lys Ser Gln Ser 
    210                 215                 220                 


Phe Lys Thr Gln Lys Lys Val Cys Phe Pro Asn Leu Ile Phe Pro Phe 
225                 230                 235                 240 


Cys Lys Ser Gln Cys Leu His Tyr Leu Ser Trp Arg Leu Lys Ile Ile 
                245                 250                 255     


Pro 
    


<210>  2304
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  2304

Met Gly Ser Trp Ala Leu Leu Trp Pro Pro Leu Leu Phe Thr Gly Leu 
1               5                   10                  15      


Leu Val Arg Pro Pro Gly Thr Met Ala Gln Ala Gln Tyr Cys Ser Val 
            20                  25                  30          


Asn Lys Asp Ile Phe Glu Val Glu Glu Asn Thr Asn Val Thr Glu Pro 
        35                  40                  45              


Leu Val Asp Ile His Val Pro Glu Gly Gln Glu Val Thr Leu Gly Ala 
    50                  55                  60                  


Leu Ser Thr Pro Phe Ala Phe Arg Ile Gln Gly Asn Gln Leu Phe Leu 
65                  70                  75                  80  


Asn Val Thr Pro Asp Tyr Glu Glu Lys Ser Leu Leu Glu Ala Gln Leu 
                85                  90                  95      


Leu Cys Gln Ser Gly Gly Thr Leu Val Thr Gln Leu Arg Val Phe Val 
            100                 105                 110         


Ser Val Leu Asp Val Asn Asp Asn Ala Pro Glu Phe Pro Phe Lys Thr 
        115                 120                 125             


Lys Glu Ile Arg Val Glu Glu Asp Thr Lys Val Asn Ser Thr Val Ile 
    130                 135                 140                 


Pro Glu Thr Gln Leu Gln Ala Glu Asp Arg Asp Lys Asp Asp Ile Leu 
145                 150                 155                 160 


Phe Tyr Thr Leu Gln Glu Met Thr Ala Gly Ala Ser Asp Tyr Phe Ser 
                165                 170                 175     


Leu Val Ser Val Asn Arg Pro Ala Leu Arg Leu Asp Arg Pro Leu Asp 
            180                 185                 190         


Phe Tyr Glu Arg Pro Asn Met Thr Phe Trp Leu Leu Val Arg Asp Thr 
        195                 200                 205             


Pro Gly Glu Asn Val Glu Pro Ser His Thr Ala Thr Ala Thr Leu Val 
    210                 215                 220                 


Leu Asn Val Val Pro Ala Asp Leu Arg Pro Pro Trp Phe Leu Pro Cys 
225                 230                 235                 240 


Thr Phe Ser Asp Gly Tyr Val Cys Ile Gln Ala Gln Tyr His Gly Ala 
                245                 250                 255     


Val Pro Thr Gly His Ile Leu Pro Ser Pro Leu Val Leu Arg Pro Gly 
            260                 265                 270         


Pro Ile Tyr Ala Glu Asp Gly Asp Arg Gly Ile Asn Gln Pro Ile Ile 
        275                 280                 285             


Tyr Ser Ile Phe Arg Gly Asn Val Asn Gly Thr Phe Ile Ile His Pro 
    290                 295                 300                 


Asp Ser Gly Asn Leu Thr Val Ala Arg Ser Val Pro Ser Pro Met Thr 
305                 310                 315                 320 


Phe Leu Leu Leu Val Lys Gly Gln Gln Ala Asp Leu Ala Arg Tyr Ser 
                325                 330                 335     


Val Thr Gln Val Thr Val Glu Ala Val Ala Ala Ala Gly Ser Pro Pro 
            340                 345                 350         


Arg Phe Pro Gln Arg Leu Tyr Arg Gly Thr Val Ala Arg Gly Ala Gly 
        355                 360                 365             


Ala Gly Val Val Val Lys Asp Ala Ala Ala Pro Ser Gln Pro Leu Arg 
    370                 375                 380                 


Ile Gln Ala Gln Asp Pro Glu Phe Ser Asp Leu Asn Ser Ala Ile Thr 
385                 390                 395                 400 


Tyr Arg Ile Thr Asn His Ser His Phe Arg Met Glu Gly Glu Val Val 
                405                 410                 415     


Leu Thr Thr Thr Thr Leu Ala Gln Ala Gly Ala Phe Tyr Ala Glu Val 
            420                 425                 430         


Glu Ala His Asn Thr Val Thr Ser Gly Thr Ala Thr Thr Val Ile Glu 
        435                 440                 445             


Ile Gln Val Ser Glu Gln Glu Pro Pro Ser Thr Glu Ala Gly Gly Thr 
    450                 455                 460                 


Thr Gly Pro Trp Thr Ser Thr Thr Ser Glu Val Pro Arg Pro Pro Glu 
465                 470                 475                 480 


Pro Ser Gln Gly Pro Ser Thr Thr Ser Ser Gly Gly Gly Thr Gly Pro 
                485                 490                 495     


His Pro Pro Ser Gly Thr Thr Leu Arg Pro Pro Thr Ser Ser Thr Pro 
            500                 505                 510         


Gly Gly Pro Pro Gly Ala Glu Asn Ser Thr Ser His Gln Pro Ala Thr 
        515                 520                 525             


Pro Gly Gly Asp Thr Ala Gln Thr Pro Lys Pro Gly Thr Ser Gln Pro 
    530                 535                 540                 


Met Pro Pro Gly Val Gly Thr Ser Thr Ser His Gln Pro Ala Thr Pro 
545                 550                 555                 560 


Ser Gly Gly Thr Ala Gln Thr Pro Glu Pro Gly Thr Ser Gln Pro Met 
                565                 570                 575     


Pro Pro Ser Met Gly Thr Ser Thr Ser His Gln Pro Ala Thr Pro Gly 
            580                 585                 590         


Gly Gly Thr Ala Gln Thr Pro Glu Ala Gly Thr Ser Gln Pro Met Pro 
        595                 600                 605             


Pro Gly Met Gly Thr Ser Thr Ser His Gln Pro Thr Thr Pro Gly Gly 
    610                 615                 620                 


Gly Thr Ala Gln Thr Pro Glu Pro Gly Thr Ser Gln Pro Met Pro Leu 
625                 630                 635                 640 


Ser Lys Ser Thr Pro Ser Ser Gly Gly Gly Pro Ser Glu Asp Lys Arg 
                645                 650                 655     


Phe Ser Val Val Asp Met Ala Ala Leu Gly Gly Val Leu Gly Ala Leu 
            660                 665                 670         


Leu Leu Leu Ala Leu Leu Gly Leu Ala Val Leu Val His Lys His Tyr 
        675                 680                 685             


Gly Pro Arg Leu Lys Cys Cys Ser Gly Lys Ala Pro Glu Pro Gln Pro 
    690                 695                 700                 


Gln Gly Phe Asp Asn Gln Ala Phe Leu Pro Asp His Lys Ala Asn Trp 
705                 710                 715                 720 


Ala Pro Val Pro Ser Pro Thr His Asp Pro Lys Pro Ala Glu Ala Pro 
                725                 730                 735     


Met Pro Ala Glu Pro Ala Pro Pro Gly Pro Ala Ser Pro Gly Gly Ala 
            740                 745                 750         


Pro Glu Pro Pro Ala Ala Ala Arg Ala Gly Gly Ser Pro Thr Ala Val 
        755                 760                 765             


Arg Ser Ile Leu Thr Lys Glu Arg Arg Pro Glu Gly Gly Tyr Lys Ala 
    770                 775                 780                 


Val Trp Phe Gly Glu Asp Ile Gly Thr Glu Ala Asp Val Val Val Leu 
785                 790                 795                 800 


Asn Ala Pro Thr Leu Asp Val Asp Gly Ala Ser Asp Ser Gly Ser Gly 
                805                 810                 815     


Asp Glu Gly Glu Gly Ala Gly Arg Gly Gly Gly Pro Tyr Asp Ala Pro 
            820                 825                 830         


Gly Gly Asp Asp Ser Tyr Ile 
        835                 


<210>  2305
<211>  745
<212>  PRT
<213>  Homo sapiens

<400>  2305

Met Arg Arg Cys Arg Trp Ala Ala Leu Ala Leu Gly Leu Leu Arg Leu 
1               5                   10                  15      


Cys Leu Ala Gln Ala Asn Phe Ala Pro His Phe Phe Asp Asn Gly Val 
            20                  25                  30          


Gly Ser Thr Asn Gly Asn Met Ala Leu Phe Ser Leu Pro Glu Asp Thr 
        35                  40                  45              


Pro Val Gly Ser His Val Tyr Thr Leu Asn Gly Thr Asp Pro Glu Gly 
    50                  55                  60                  


Asp Pro Ile Ser Tyr His Ile Ser Phe Asp Pro Ser Thr Arg Ser Val 
65                  70                  75                  80  


Phe Ser Val Asp Pro Thr Phe Gly Asn Ile Thr Leu Val Glu Glu Leu 
                85                  90                  95      


Asp Arg Glu Arg Glu Asp Glu Ile Glu Ala Ile Ile Ser Ile Ser Asp 
            100                 105                 110         


Gly Leu Asn Leu Val Ala Glu Lys Val Val Ile Leu Val Thr Asp Ala 
        115                 120                 125             


Asn Asp Glu Ala Pro Arg Phe Ile Gln Glu Pro Tyr Val Ala Leu Val 
    130                 135                 140                 


Pro Glu Asp Ile Pro Ala Gly Ser Ile Ile Phe Lys Val His Ala Val 
145                 150                 155                 160 


Asp Arg Asp Thr Gly Ser Gly Gly Ser Val Thr Tyr Phe Leu Gln Asn 
                165                 170                 175     


Leu His Ser Pro Phe Ala Val Asp Arg His Ser Gly Val Leu Arg Leu 
            180                 185                 190         


Gln Ala Gly Ala Thr Leu Asp Tyr Glu Arg Ser Arg Thr His Tyr Ile 
        195                 200                 205             


Thr Val Val Ala Lys Asp Gly Gly Gly Arg Leu His Gly Ala Asp Val 
    210                 215                 220                 


Val Phe Ser Ala Thr Thr Thr Val Thr Val Asn Val Glu Asp Val Gln 
225                 230                 235                 240 


Asp Met Ala Pro Val Phe Val Gly Thr Pro Tyr Tyr Gly Tyr Val Tyr 
                245                 250                 255     


Glu Asp Thr Leu Pro Gly Ser Glu Val Leu Lys Val Val Ala Met Asp 
            260                 265                 270         


Gly Asp Arg Gly Lys Pro Asn Arg Ile Leu Tyr Ser Leu Val Asn Gly 
        275                 280                 285             


Asn Asp Gly Ala Phe Glu Ile Asn Glu Thr Ser Gly Ala Ile Ser Ile 
    290                 295                 300                 


Thr Gln Ser Pro Ala Gln Leu Gln Arg Glu Val Tyr Glu Leu His Val 
305                 310                 315                 320 


Gln Val Thr Glu Met Ser Pro Ala Gly Ser Pro Ala Ala Gln Ala Thr 
                325                 330                 335     


Val Pro Val Thr Ile Arg Ile Val Asp Leu Asn Asn His Pro Pro Thr 
            340                 345                 350         


Phe Tyr Gly Glu Ser Gly Pro Gln Asn Arg Phe Glu Leu Ser Met Asn 
        355                 360                 365             


Glu His Pro Pro Gln Gly Glu Ile Leu Arg Gly Leu Lys Ile Thr Val 
    370                 375                 380                 


Asn Asp Ser Asp Gln Gly Ala Asn Ala Lys Phe Asn Leu Gln Leu Val 
385                 390                 395                 400 


Gly Pro Arg Gly Ile Phe Arg Val Val Pro Gln Thr Val Leu Asn Glu 
                405                 410                 415     


Ala Gln Val Thr Ile Ile Val Glu Asn Ser Ala Ala Ile Asp Phe Glu 
            420                 425                 430         


Lys Ser Lys Val Leu Thr Phe Lys Leu Leu Ala Val Glu Val Asn Thr 
        435                 440                 445             


Pro Glu Lys Phe Ser Ser Thr Ala Asp Val Val Ile Gln Leu Leu Asp 
    450                 455                 460                 


Thr Asn Asp Asn Val Pro Lys Phe Asp Ser Leu Tyr Tyr Val Ala Arg 
465                 470                 475                 480 


Ile Pro Glu Asn Ala Pro Gly Gly Ser Ser Val Val Ala Val Thr Ala 
                485                 490                 495     


Val Asp Pro Asp Thr Gly Pro Trp Gly Glu Val Lys Tyr Ser Thr Tyr 
            500                 505                 510         


Gly Thr Gly Ala Asp Leu Phe Leu Ile His Pro Ser Thr Gly Leu Ile 
        515                 520                 525             


Tyr Thr Gln Pro Trp Ala Ser Leu Asp Ala Glu Ala Thr Ala Arg Tyr 
    530                 535                 540                 


Asn Phe Tyr Val Lys Ala Glu Asp Met Glu Gly Lys Tyr Ser Val Ala 
545                 550                 555                 560 


Glu Val Phe Ile Thr Leu Leu Asp Val Asn Asp His Pro Pro Gln Phe 
                565                 570                 575     


Gly Lys Ser Val Gln Lys Lys Thr Met Val Leu Gly Thr Pro Val Lys 
            580                 585                 590         


Ile Glu Ala Ile Asp Glu Asp Ala Glu Glu Pro Asn Asn Leu Val Asp 
        595                 600                 605             


Tyr Ser Ile Thr His Ala Glu Pro Ala Asn Val Phe Asp Ile Asn Ser 
    610                 615                 620                 


His Thr Gly Glu Ile Trp Leu Lys Asn Ser Ile Arg Ser Leu Asp Ala 
625                 630                 635                 640 


Leu His Asn Ile Thr Pro Gly Arg Asp Cys Leu Trp Ser Leu Glu Val 
                645                 650                 655     


Gln Ala Lys Asp Arg Gly Ser Pro Ser Phe Ser Thr Thr Ala Leu Leu 
            660                 665                 670         


Lys Ile Asp Ile Thr Asp Ala Glu Val Arg Arg Leu Arg Tyr Met Lys 
        675                 680                 685             


Asn Ser Asn Phe Pro Gly Thr Thr Lys Ser Val Arg Lys Pro Lys Phe 
    690                 695                 700                 


Lys Pro Lys Lys Pro His Ser Ser Gln Gly Leu Phe Leu His Pro His 
705                 710                 715                 720 


Cys Glu Ile Ala Leu Phe Asn Leu Ser Asn Val Asn Leu Tyr Ser Arg 
                725                 730                 735     


Val Phe Gln Gly Ala Ala Gln Ala Ser 
            740                 745 


<210>  2306
<211>  1310
<212>  PRT
<213>  Homo sapiens

<400>  2306

Met Ala Gln Leu Trp Leu Ser Cys Phe Leu Leu Pro Ala Leu Val Val 
1               5                   10                  15      


Ser Val Ala Ala Asn Val Ala Pro Lys Phe Leu Ala Asn Met Thr Ser 
            20                  25                  30          


Val Ile Leu Pro Glu Asp Leu Pro Val Gly Ala Gln Ala Phe Trp Leu 
        35                  40                  45              


Val Ala Glu Asp Gln Asp Asn Asp Pro Leu Thr Tyr Gly Met Ser Gly 
    50                  55                  60                  


Pro Asn Ala Tyr Phe Phe Ala Val Thr Pro Lys Thr Gly Glu Val Lys 
65                  70                  75                  80  


Leu Ala Ser Ala Leu Asp Tyr Glu Thr Leu Tyr Thr Phe Lys Val Thr 
                85                  90                  95      


Ile Ser Val Ser Asp Pro Tyr Ile Gln Val Gln Arg Glu Met Leu Val 
            100                 105                 110         


Ile Val Glu Asp Arg Asn Asp Asn Ala Pro Val Phe Gln Asn Thr Ala 
        115                 120                 125             


Phe Ser Thr Ser Ile Asn Glu Thr Leu Pro Val Gly Ser Val Val Phe 
    130                 135                 140                 


Ser Val Leu Ala Val Asp Lys Asp Met Gly Ser Ala Gly Met Val Val 
145                 150                 155                 160 


Tyr Ser Ile Glu Lys Val Ile Pro Ser Thr Gly Asp Ser Glu His Leu 
                165                 170                 175     


Phe Arg Ile Leu Ala Asn Gly Ser Ile Val Leu Asn Gly Ser Leu Ser 
            180                 185                 190         


Tyr Asn Asn Lys Ser Ala Phe Tyr Gln Leu Glu Leu Lys Ala Cys Asp 
        195                 200                 205             


Leu Gly Gly Met Tyr His Asn Thr Phe Thr Ile Gln Cys Ser Leu Pro 
    210                 215                 220                 


Val Phe Leu Ser Ile Ser Val Val Asp Gln Pro Asp Leu Asp Pro Gln 
225                 230                 235                 240 


Phe Val Arg Glu Phe Tyr Ser Ala Ser Val Ala Glu Asp Ala Ala Lys 
                245                 250                 255     


Gly Thr Ser Val Leu Thr Val Glu Ala Val Asp Gly Asp Lys Gly Ile 
            260                 265                 270         


Asn Asp Pro Val Ile Tyr Ser Ile Ser Tyr Ser Thr Arg Pro Gly Trp 
        275                 280                 285             


Phe Asp Ile Gly Ala Asp Gly Val Ile Arg Val Asn Gly Ser Leu Asp 
    290                 295                 300                 


Arg Glu Gln Leu Leu Glu Ala Asp Glu Glu Val Gln Leu Gln Val Thr 
305                 310                 315                 320 


Ala Thr Glu Thr His Leu Asn Ile Tyr Gly Gln Glu Ala Lys Val Ser 
                325                 330                 335     


Ile Trp Val Thr Val Arg Val Met Asp Val Asn Asp His Lys Pro Glu 
            340                 345                 350         


Phe Tyr Asn Cys Ser Leu Pro Ala Cys Thr Phe Thr Pro Glu Glu Ala 
        355                 360                 365             


Gln Val Asn Phe Thr Gly Tyr Val Asp Glu His Ala Ser Pro Arg Ile 
    370                 375                 380                 


Pro Ile Asp Asp Leu Thr Met Val Val Tyr Asp Pro Asp Lys Gly Ser 
385                 390                 395                 400 


Asn Gly Thr Phe Leu Leu Ser Leu Gly Gly Pro Asp Ala Glu Ala Phe 
                405                 410                 415     


Ser Val Ser Pro Glu Arg Ala Val Gly Ser Ala Ser Val Gln Val Leu 
            420                 425                 430         


Val Arg Val Ser Ala Leu Val Asp Tyr Glu Arg Gln Thr Ala Met Ala 
        435                 440                 445             


Val Gln Val Val Ala Thr Asp Ser Val Ser Gln Asn Phe Ser Val Ala 
    450                 455                 460                 


Met Val Thr Ile His Leu Arg Asp Ile Asn Asp His Arg Pro Thr Phe 
465                 470                 475                 480 


Pro Gln Ser Leu Tyr Val Leu Thr Val Pro Glu His Ser Ala Thr Gly 
                485                 490                 495     


Ser Val Val Thr Asp Ser Ile His Ala Thr Asp Pro Asp Thr Gly Ala 
            500                 505                 510         


Trp Gly Gln Ile Thr Tyr Ser Leu Leu Pro Gly Asn Gly Ala Asp Leu 
        515                 520                 525             


Phe Gln Val Asp Pro Val Ser Gly Thr Val Thr Val Arg Asn Gly Glu 
    530                 535                 540                 


Leu Leu Asp Arg Glu Ser Gln Ala Val Tyr Tyr Leu Thr Leu Gln Ala 
545                 550                 555                 560 


Thr Asp Gly Gly Asn Leu Ser Ser Ser Thr Thr Leu Gln Ile His Leu 
                565                 570                 575     


Leu Asp Ile Asn Asp Asn Ala Pro Val Val Ser Gly Ser Tyr Asn Ile 
            580                 585                 590         


Phe Val Gln Glu Glu Glu Gly Asn Val Ser Val Thr Ile Gln Ala His 
        595                 600                 605             


Asp Asn Asp Glu Pro Gly Thr Asn Asn Ser Arg Leu Leu Phe Asn Leu 
    610                 615                 620                 


Leu Pro Gly Pro Tyr Ser His Asn Phe Ser Leu Asp Pro Asp Thr Gly 
625                 630                 635                 640 


Leu Leu Arg Asn Leu Gly Pro Leu Asp Arg Glu Ala Ile Asp Pro Ala 
                645                 650                 655     


Leu Glu Gly Arg Ile Val Leu Thr Val Leu Val Ser Asp Cys Gly Glu 
            660                 665                 670         


Pro Val Leu Gly Thr Lys Val Asn Val Thr Ile Thr Val Glu Asp Ile 
        675                 680                 685             


Asn Asp Asn Leu Pro Ile Phe Asn Gln Ser Ser Tyr Asn Phe Thr Val 
    690                 695                 700                 


Lys Glu Glu Asp Pro Gly Val Leu Val Gly Val Val Lys Ala Trp Asp 
705                 710                 715                 720 


Ala Asp Gln Thr Glu Ala Asn Asn Arg Ile Ser Phe Ser Leu Ser Gly 
                725                 730                 735     


Ser Gly Ala Asn Tyr Phe Met Ile Arg Gly Leu Val Leu Gly Ala Gly 
            740                 745                 750         


Trp Ala Glu Gly Tyr Leu Arg Leu Pro Pro Asp Val Ser Leu Asp Tyr 
        755                 760                 765             


Glu Thr Gln Pro Val Phe Asn Leu Thr Val Ser Ala Glu Asn Pro Asp 
    770                 775                 780                 


Pro Gln Gly Gly Glu Thr Ile Val Asp Val Cys Val Asn Val Lys Asp 
785                 790                 795                 800 


Val Asn Asp Asn Pro Pro Thr Leu Asp Val Ala Ser Leu Arg Gly Ile 
                805                 810                 815     


Arg Val Ala Glu Asn Gly Ser Gln His Gly Gln Val Ala Val Val Val 
            820                 825                 830         


Ala Ser Asp Val Asp Thr Ser Ala Gln Leu Glu Ile Gln Leu Val Asn 
        835                 840                 845             


Ile Leu Cys Thr Lys Ala Gly Val Asp Val Gly Ser Leu Cys Trp Gly 
    850                 855                 860                 


Trp Phe Ser Val Ala Ala Asn Gly Ser Val Tyr Ile Asn Gln Ser Lys 
865                 870                 875                 880 


Ala Ile Asp Tyr Glu Ala Cys Asp Leu Val Thr Leu Val Val Arg Ala 
                885                 890                 895     


Cys Asp Leu Ala Thr Asp Pro Gly Phe Gln Ala Tyr Ser Asn Asn Gly 
            900                 905                 910         


Ser Leu Leu Ile Thr Ile Glu Asp Val Asn Asp Asn Ala Pro Tyr Phe 
        915                 920                 925             


Leu Pro Glu Asn Lys Thr Phe Val Ile Ile Pro Glu Leu Val Leu Pro 
    930                 935                 940                 


Asn Arg Glu Val Ala Ser Val Arg Ala Arg Asp Asp Asp Ser Gly Asn 
945                 950                 955                 960 


Asn Gly Val Ile Leu Phe Ser Ile Leu Arg Val Asp Phe Ile Ser Lys 
                965                 970                 975     


Asp Gly Ala Thr Ile Pro Phe Gln Gly Val Phe Ser Ile Phe Thr Ser 
            980                 985                 990         


Ser Glu Ala Asp Val Phe Ala Gly  Ser Ile Gln Pro Val  Thr Ser Leu 
        995                 1000                 1005             


Asp Ser  Thr Leu Gln Gly Thr  Tyr Gln Val Thr Val  Gln Ala Arg 
    1010                 1015                 1020             


Asp Arg  Pro Ser Leu Gly Pro  Phe Leu Glu Ala Thr  Thr Thr Leu 
    1025                 1030                 1035             


Asn Leu  Phe Thr Val Asp Gln  Ser Tyr Arg Ser Arg  Leu Gln Phe 
    1040                 1045                 1050             


Ser Thr  Pro Lys Glu Glu Val  Gly Ala Asn Arg Gln  Ala Ile Asn 
    1055                 1060                 1065             


Ala Ala  Leu Thr Gln Ala Thr  Arg Thr Thr Val Tyr  Ile Val Asp 
    1070                 1075                 1080             


Ile Gln  Asp Ile Asp Ser Ala  Ala Arg Ala Arg Pro  His Ser Tyr 
    1085                 1090                 1095             


Leu Asp  Ala Tyr Phe Val Phe  Pro Asn Gly Ser Ala  Leu Thr Leu 
    1100                 1105                 1110             


Asp Glu  Leu Ser Val Met Ile  Arg Asn Asp Gln Asp  Ser Leu Thr 
    1115                 1120                 1125             


Gln Leu  Leu Gln Leu Gly Leu  Val Val Leu Gly Ser  Gln Glu Ser 
    1130                 1135                 1140             


Gln Glu  Ser Asp Leu Ser Lys  Gln Leu Ile Ser Val  Ile Ile Gly 
    1145                 1150                 1155             


Leu Gly  Val Ala Leu Leu Leu  Val Leu Val Ile Met  Thr Met Ala 
    1160                 1165                 1170             


Phe Val  Cys Val Arg Lys Ser  Tyr Asn Arg Lys Leu  Gln Ala Met 
    1175                 1180                 1185             


Lys Ala  Ala Lys Glu Ala Arg  Lys Thr Ala Ala Gly  Val Met Pro 
    1190                 1195                 1200             


Ser Ala  Pro Ala Ile Pro Gly  Thr Asn Met Tyr Asn  Thr Glu Arg 
    1205                 1210                 1215             


Ala Asn  Pro Met Leu Asn Leu  Pro Asn Lys Asp Leu  Gly Leu Glu 
    1220                 1225                 1230             


Tyr Leu  Ser Pro Ser Asn Asp  Leu Asp Ser Val Ser  Val Asn Ser 
    1235                 1240                 1245             


Leu Asp  Asp Asn Ser Val Asp  Val Asp Lys Asn Ser  Gln Glu Ile 
    1250                 1255                 1260             


Lys Glu  His Arg Pro Pro His  Thr Pro Pro Glu Pro  Asp Pro Glu 
    1265                 1270                 1275             


Pro Leu  Ser Val Val Leu Leu  Gly Arg Gln Ala Gly  Ala Ser Gly 
    1280                 1285                 1290             


Gln Leu  Glu Gly Pro Ser Tyr  Thr Asn Ala Gly Leu  Asp Thr Thr 
    1295                 1300                 1305             


Asp Leu  
    1310 


<210>  2307
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  2307

Met Glu Asn Leu Ser Leu Ser Ile Glu Asp Val Gln Pro Arg Ser Pro 
1               5                   10                  15      


Gly Arg Ser Ser Leu Asp Asp Ser Gly Glu Arg Asp Glu Lys Leu Ser 
            20                  25                  30          


Lys Ser Ile Ser Phe Thr Ser Glu Ser Ile Ser Arg Val Ser Glu Thr 
        35                  40                  45              


Glu Ser Phe Asp Gly Asn Ser Ser Lys Gly Gly Leu Gly Lys Glu Glu 
    50                  55                  60                  


Ser Gln Asn Glu Lys Gln Thr Lys Lys Ser Leu Leu Pro Thr Leu Glu 
65                  70                  75                  80  


Lys Lys Leu Thr Arg Val Pro Ser Lys Ser Leu Asp Leu Asn Lys Asn 
                85                  90                  95      


Glu Tyr Leu Ser Leu Asp Lys Ser Ser Thr Ser Asp Ser Val Asp Glu 
            100                 105                 110         


Glu Asn Val Pro Glu Lys Asp Leu His Gly Arg Leu Phe Ile Asn Arg 
        115                 120                 125             


Ile Phe His Ile Ser Ala Asp Arg Met Phe Glu Leu Leu Phe Thr Ser 
    130                 135                 140                 


Ser Arg Phe Met Gln Lys Phe Ala Ser Ser Arg Asn Ile Ile Asp Val 
145                 150                 155                 160 


Val Ser Thr Pro Trp Thr Ala Glu Leu Gly Gly Asp Gln Leu Arg Thr 
                165                 170                 175     


Met Thr Tyr Thr Ile Val Leu Asn Ser Pro Leu Thr Gly Lys Cys Thr 
            180                 185                 190         


Ala Ala Thr Glu Lys Gln Thr Leu Tyr Lys Glu Ser Arg Glu Ala Arg 
        195                 200                 205             


Phe Tyr Leu Val Asp Ser Glu Val Leu Thr His Asp Val Pro Tyr His 
    210                 215                 220                 


Asp Tyr Phe Tyr Thr Val Asn Arg Tyr Cys Ile Ile Arg Ser Ser Lys 
225                 230                 235                 240 


Gln Lys Cys Arg Leu Arg Val Ser Thr Asp Leu Lys Tyr Arg Lys Gln 
                245                 250                 255     


Pro Trp Gly Leu Val Lys Ser Leu Ile Glu Lys Asn Ser Trp Ser Ser 
            260                 265                 270         


Leu Glu Asp Tyr Phe Lys Gln Leu Glu Ser Asp Leu Leu Ile Glu Glu 
        275                 280                 285             


Ser Val Leu Asn Gln Ala Ile Glu Asp Pro Gly Lys Leu Thr Gly Leu 
    290                 295                 300                 


Arg Arg Arg Arg Arg Thr Phe Asn Arg Thr Ala Glu Thr Val Pro Lys 
305                 310                 315                 320 


Leu Ser Ser Gln His Ser Ser Gly Asp Val Gly Leu Gly Ala Lys Gly 
                325                 330                 335     


Asp Ile Thr Gly Lys Lys Lys Glu Met Glu Asn Tyr Asn Val Thr Leu 
            340                 345                 350         


Ile Val Val Met Ser Ile Phe Val Leu Leu Leu Val Leu Leu Asn Val 
        355                 360                 365             


Thr Leu Phe Leu Lys Leu Ser Lys Ile Glu His Ala Ala Gln Ser Phe 
    370                 375                 380                 


Tyr Arg Leu Arg Leu Gln Glu Glu Lys Ser Leu Asn Leu Ala Ser Asp 
385                 390                 395                 400 


Met Val Ser Arg Ala Glu Thr Ile Gln Lys Asn Lys Asp Gln Ala His 
                405                 410                 415     


Arg Leu Lys Gly Val Leu Arg Asp Ser Ile Val Met Leu Glu Gln Leu 
            420                 425                 430         


Lys Ser Ser Leu Ile Met Leu Gln Lys Thr Phe Asp Leu Leu Asn Lys 
        435                 440                 445             


Asn Lys Thr Gly Met Ala Val Glu Ser 
    450                 455         


<210>  2308
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  2308

Met Pro Gly Asp Ser Ser Pro Gly Thr Leu Pro Leu Trp Asp Ala Ser 
1               5                   10                  15      


Leu Ser Pro Pro Leu Gly Pro Asp Pro Gly Gly Phe Ser Arg Ala Ser 
            20                  25                  30          


His Ala Gly Asp Lys Ser Arg Pro Pro Ala Pro Glu Leu Gly Ser Pro 
        35                  40                  45              


Gly Ala Val Arg Pro Arg Val Gly Ser Cys Ala Pro Gly Pro Met Glu 
    50                  55                  60                  


Leu Arg Val Ser Asn Thr Ser Cys Glu Asn Gly Ser Leu Leu His Leu 
65                  70                  75                  80  


Tyr Cys Ser Ser Gln Glu Val Leu Cys Gln Ile Val Asn Asp Leu Ser 
                85                  90                  95      


Pro Glu Val Pro Ser Asn Ala Thr Phe His Ser Trp Gln Glu Arg Ile 
            100                 105                 110         


Arg Gln Asn Tyr Gly Phe Tyr Ile Gly Leu Gly Leu Ala Phe Leu Ser 
        115                 120                 125             


Ser Phe Leu Ile Gly Ser Ser Val Ile Leu Lys Lys Lys Gly Leu Leu 
    130                 135                 140                 


Arg Leu Val Ala Thr Gly Ala Thr Arg Ala Val Ala Ala Gly Glu Val 
145                 150                 155                 160 


Ala Asn Phe Gly Ala Tyr Ala Phe Ala Pro Ala Thr Val Val Thr Pro 
                165                 170                 175     


Leu Gly Ala Leu Ser Val Leu Ile Ser Ala Ile Leu Ser Ser Tyr Phe 
            180                 185                 190         


Leu Arg Glu Ser Leu Asn Leu Leu Gly Lys Leu Gly Cys Val Ile Cys 
        195                 200                 205             


Val Ala Gly Ser Thr Val Met Val Ile His Ala Pro Glu Glu Glu Lys 
    210                 215                 220                 


Val Thr Thr Ile Met Glu Met Ala Ser Lys Met Lys Asp Thr Gly Phe 
225                 230                 235                 240 


Ile Val Phe Ala Val Leu Leu Leu Val Ser Cys Leu Ile Leu Ile Phe 
                245                 250                 255     


Val Ile Ala Pro Arg Tyr Gly Gln Arg Asn Ile Leu Ile Tyr Ile Ile 
            260                 265                 270         


Ile Cys Ser Val Ile Gly Ala Phe Ser Val Ala Ala Val Lys Gly Leu 
        275                 280                 285             


Gly Ile Thr Ile Lys Asn Phe Phe Gln Gly Leu Pro Val Val Arg His 
    290                 295                 300                 


Pro Leu Pro Tyr Ile Leu Ser Leu Ile Leu Ala Leu Ser Leu Ser Thr 
305                 310                 315                 320 


Gln Val Asn Phe Leu Asn Arg Ala Leu Asp Ile Phe Asn Thr Ser Leu 
                325                 330                 335     


Val Phe Pro Ile Tyr Tyr Val Phe Phe Thr Thr Val Val Val Thr Ser 
            340                 345                 350         


Ser Ile Ile Leu Phe Lys Glu Trp Tyr Ser Met Ser Ala Val Asp Ile 
        355                 360                 365             


Ala Gly Thr Leu Ser Gly Phe Val Thr Ile Ile Leu Gly Val Phe Met 
    370                 375                 380                 


Leu His Ala Phe Lys Asp Leu Asp Ile Ser Cys Ala Ser Leu Pro His 
385                 390                 395                 400 


Met His Lys Asn Pro Pro Pro Ser Pro Ala Pro Glu Pro Thr Val Ile 
                405                 410                 415     


Arg Leu Glu Asp Lys Asn Val Leu Val Asp Asn Ile Glu Leu Ala Ser 
            420                 425                 430         


Thr Ser Ser Pro Glu Glu Lys Pro Lys Val Phe Ile Ile His Ser 
        435                 440                 445         


<210>  2309
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  2309

Met Lys Thr Gly His Phe Glu Ile Val Thr Met Leu Leu Ala Thr Met 
1               5                   10                  15      


Ile Leu Val Asp Ile Phe Gln Val Lys Ala Glu Val Leu Asp Met Ala 
            20                  25                  30          


Asp Asn Ala Phe Asp Asp Glu Tyr Leu Lys Cys Thr Asp Arg Met Glu 
        35                  40                  45              


Ile Lys Tyr Val Pro Gln Leu Leu Lys Glu Glu Lys Ala Ser His Gln 
    50                  55                  60                  


Gln Leu Asp Thr Val Trp Glu Asn Ala Lys Ala Lys Trp Ala Ala Arg 
65                  70                  75                  80  


Lys Thr Gln Ile Phe Leu Pro Met Asn Phe Lys Asp Asn His Gly Ile 
                85                  90                  95      


Ala Leu Met Ala Tyr Ile Ser Glu Ala Gln Glu Gln Thr Pro Phe Tyr 
            100                 105                 110         


His Leu Phe Ser Glu Ala Val Lys Met Ala Gly Gln Ser Arg Glu Asp 
        115                 120                 125             


Tyr Ile Tyr Gly Phe Gln Phe Lys Ala Phe His Phe Tyr Leu Thr Arg 
    130                 135                 140                 


Ala Leu Gln Leu Leu Arg Lys Pro Cys Glu Ala Ser Ser Lys Thr Val 
145                 150                 155                 160 


Val Tyr Arg Thr Ser Gln Gly Thr Ser Phe Thr Phe Gly Gly Leu Asn 
                165                 170                 175     


Gln Ala Arg Phe Gly His Phe Thr Leu Ala Tyr Ser Ala Lys Pro Gln 
            180                 185                 190         


Ala Ala Asn Asp Gln Leu Thr Val Leu Ser Ile Tyr Thr Cys Leu Gly 
        195                 200                 205             


Val Asp Ile Glu Asn Phe Leu Asp Lys Glu Ser Glu Arg Ile Thr Leu 
    210                 215                 220                 


Ile Pro Leu Asn Glu Val Phe Gln Val Ser Gln Glu Gly Ala Gly Asn 
225                 230                 235                 240 


Asn Leu Ile Leu Gln Ser Ile Asn Lys Thr Cys Ser His Tyr Glu Cys 
                245                 250                 255     


Ala Phe Leu Gly Gly Leu Lys Thr Glu Asn Cys Ile Glu Asn Leu Glu 
            260                 265                 270         


Tyr Phe Gln Pro Ile Tyr Val Tyr Asn Pro Gly Glu Lys Asn Gln Lys 
        275                 280                 285             


Leu Glu Asp His Ser Glu Lys Asn Trp Lys Leu Glu Asp His Gly Glu 
    290                 295                 300                 


Lys Asn Gln Lys Leu Glu Asp His Gly Val Lys Ile Leu Glu Pro Thr 
305                 310                 315                 320 


Gln Ile Pro Glu Asp Lys Ser Gln Gly Asn Ile Asn Asn Pro Thr Pro 
                325                 330                 335     


Gly Pro Val Pro Val Pro Gly Pro Lys Ser His Pro Ser Ala Ser Ser 
            340                 345                 350         


Gly Lys Leu Leu Leu Pro Gln Phe Gly Met Val Ile Ile Leu Ile Ser 
        355                 360                 365             


Val Ser Ala Ile Asn Leu Phe Val Ala Leu 
    370                 375             


<210>  2310
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  2310

Met Met Ala Ala Met Ala Thr Ala Arg Val Arg Met Gly Pro Arg Cys 
1               5                   10                  15      


Ala Gln Ala Leu Trp Arg Met Pro Trp Leu Pro Val Phe Leu Ser Leu 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Ala Glu Gln Gln Val Pro Leu Val 
        35                  40                  45              


Leu Trp Ser Ser Asp Arg Asp Leu Trp Ala Pro Ala Ala Asp Thr His 
    50                  55                  60                  


Glu Gly His Ile Thr Ser Asp Leu Gln Leu Ser Thr Tyr Leu Asp Pro 
65                  70                  75                  80  


Ala Leu Glu Leu Gly Pro Arg Asn Val Leu Leu Phe Leu Gln Asp Lys 
                85                  90                  95      


Leu Ser Ile Glu Asp Phe Thr Ala Tyr Gly Gly Val Phe Gly Asn Lys 
            100                 105                 110         


Gln Asp Ser Ala Phe Ser Asn Leu Glu Asn Ala Leu Asp Leu Ala Pro 
        115                 120                 125             


Ser Ser Leu Val Leu Pro Ala Val Asp Trp Tyr Ala Val Ser Thr Leu 
    130                 135                 140                 


Thr Thr Tyr Leu Gln Glu Lys Leu Gly Ala Ser Pro Leu His Val Asp 
145                 150                 155                 160 


Leu Ala Thr Leu Arg Glu Leu Lys Leu Asn Ala Ser Leu Pro Ala Leu 
                165                 170                 175     


Leu Leu Ile Arg Leu Pro Tyr Thr Ala Ser Ser Gly Leu Met Ala Pro 
            180                 185                 190         


Arg Glu Val Leu Thr Gly Asn Asp Glu Val Ile Gly Gln Val Leu Ser 
        195                 200                 205             


Thr Leu Lys Ser Glu Asp Val Pro Tyr Thr Ala Ala Leu Thr Ala Val 
    210                 215                 220                 


Arg Pro Ser Arg Val Ala Arg Asp Val Ala Val Val Ala Gly Gly Leu 
225                 230                 235                 240 


Gly Arg Gln Leu Leu Gln Lys Gln Pro Val Ser Pro Val Ile His Pro 
                245                 250                 255     


Pro Val Ser Tyr Asn Asp Thr Ala Pro Arg Ile Leu Phe Trp Ala Gln 
            260                 265                 270         


Asn Phe Ser Val Ala Tyr Lys Asp Gln Trp Glu Asp Leu Thr Pro Leu 
        275                 280                 285             


Thr Phe Gly Val Gln Glu Leu Asn Leu Thr Gly Ser Phe Trp Asn Asp 
    290                 295                 300                 


Ser Phe Ala Arg Leu Ser Leu Thr Tyr Glu Arg Leu Phe Gly Thr Thr 
305                 310                 315                 320 


Val Thr Phe Lys Phe Ile Leu Ala Asn Arg Leu Tyr Pro Val Ser Ala 
                325                 330                 335     


Arg His Trp Phe Thr Met Glu Arg Leu Glu Val His Ser Asn Gly Ser 
            340                 345                 350         


Val Ala Tyr Phe Asn Ala Ser Gln Val Thr Gly Pro Ser Ile Tyr Ser 
        355                 360                 365             


Phe His Cys Glu Tyr Val Ser Ser Leu Ser Lys Lys Gly Ser Leu Leu 
    370                 375                 380                 


Val Ala Arg Thr Gln Pro Ser Pro Trp Gln Met Met Leu Gln Asp Phe 
385                 390                 395                 400 


Gln Ile Gln Ala Phe Asn Val Met Gly Glu Gln Phe Ser Tyr Ala Ser 
                405                 410                 415     


Asp Cys Ala Ser Phe Phe Ser Pro Gly Ile Trp Met Gly Leu Leu Thr 
            420                 425                 430         


Ser Leu Phe Met Leu Phe Ile Phe Thr Tyr Gly Leu His Met Ile Leu 
        435                 440                 445             


Ser Leu Lys Thr Met Asp Arg Phe Asp Asp His Lys Gly Pro Thr Ile 
    450                 455                 460                 


Ser Leu Thr Gln Ile Val 
465                 470 


<210>  2311
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  2311

Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
1               5                   10                  15      


Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
            20                  25                  30          


Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Met Glu Thr Pro 
        35                  40                  45              


Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala 
    50                  55                  60                  


Val Asn Gly Ala Thr Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val 
65                  70                  75                  80  


Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu 
                85                  90                  95      


Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu 
            100                 105                 110         


His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Asp Thr Phe 
        115                 120                 125             


Val Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln 
    130                 135                 140                 


Glu Arg Phe Asn Arg Trp Phe Leu Thr Gly Met Thr Val Ala Gly Val 
145                 150                 155                 160 


Val Leu Leu Gly Ser Leu Phe Ser Arg Lys 
                165                 170 


<210>  2312
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  2312

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu 
    50                  55                  60                  


Ile Ile Ser Leu Ala Val Phe Val Leu Met Phe Leu Leu Arg Lys Ile 
65                  70                  75                  80  


Asn Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly Ser Gly Leu 
                85                  90                  95      


Leu Gly Met Ala Asn Ile Asp Leu Glu Lys Ser Arg Thr Gly Asp Glu 
            100                 105                 110         


Ile Ile Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys 
        115                 120                 125             


Glu Asp Cys Ile Lys Ser Lys Pro Lys Val Asp Ser Asp His Cys Phe 
    130                 135                 140                 


Pro Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys 
145                 150                 155                 160 


Thr Asn Asp Tyr Cys Lys Ser Leu Pro Ala Ala Leu Ser Ala Thr Glu 
                165                 170                 175     


Ile Glu Lys Ser Ile Ser Ala Arg 
            180                 


<210>  2313
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  2313

Met Ser Glu Val Arg Pro Leu Ser Arg Asp Ile Leu Met Glu Thr Leu 
1               5                   10                  15      


Leu Tyr Glu Gln Leu Leu Glu Pro Pro Thr Met Glu Val Leu Gly Met 
            20                  25                  30          


Thr Asp Ser Glu Glu Asp Leu Asp Pro Met Glu Asp Phe Asp Ser Leu 
        35                  40                  45              


Glu Cys Met Glu Gly Ser Asp Ala Leu Ala Leu Arg Leu Ala Cys Ile 
    50                  55                  60                  


Gly Asp Glu Met Asp Val Ser Leu Arg Ala Pro Arg Leu Ala Gln Leu 
65                  70                  75                  80  


Ser Glu Val Ala Met His Ser Leu Gly Leu Ala Phe Ile Tyr Asp Gln 
                85                  90                  95      


Thr Glu Asp Ile Arg Asp Val Leu Arg Ser Phe Met Asp Gly Phe Thr 
            100                 105                 110         


Thr Leu Lys Glu Asn Ile Met Arg Phe Trp Arg Ser Pro Asn Pro Gly 
        115                 120                 125             


Ser Trp Val Ser Cys Glu Gln Val Leu Leu Ala Leu Leu Leu Leu Leu 
    130                 135                 140                 


Ala Leu Leu Leu Pro Leu Leu Ser Gly Gly Leu His Leu Leu Leu Lys 
145                 150                 155                 160 


<210>  2314
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  2314

Met Val Ala Gly Thr Arg Cys Leu Leu Ala Leu Leu Leu Pro Gln Val 
1               5                   10                  15      


Leu Leu Gly Gly Ala Ala Gly Leu Val Pro Glu Leu Gly Arg Arg Lys 
            20                  25                  30          


Phe Ala Ala Ala Ser Ser Gly Arg Pro Ser Ser Gln Pro Ser Asp Glu 
        35                  40                  45              


Val Leu Ser Glu Phe Glu Leu Arg Leu Leu Ser Met Phe Gly Leu Lys 
    50                  55                  60                  


Gln Arg Pro Thr Pro Ser Arg Asp Ala Val Val Pro Pro Tyr Met Leu 
65                  70                  75                  80  


Asp Leu Tyr Arg Arg His Ser Gly Gln Pro Gly Ser Pro Ala Pro Asp 
                85                  90                  95      


His Arg Leu Glu Arg Ala Ala Ser Arg Ala Asn Thr Val Arg Ser Phe 
            100                 105                 110         


His His Glu Glu Ser Leu Glu Glu Leu Pro Glu Thr Ser Gly Lys Thr 
        115                 120                 125             


Thr Arg Arg Phe Phe Phe Asn Leu Ser Ser Ile Pro Thr Glu Glu Phe 
    130                 135                 140                 


Ile Thr Ser Ala Glu Leu Gln Val Phe Arg Glu Gln Met Gln Asp Ala 
145                 150                 155                 160 


Leu Gly Asn Asn Ser Ser Phe His His Arg Ile Asn Ile Tyr Glu Ile 
                165                 170                 175     


Ile Lys Pro Ala Thr Ala Asn Ser Lys Phe Pro Val Thr Arg Leu Leu 
            180                 185                 190         


Asp Thr Arg Leu Val Asn Gln Asn Ala Ser Arg Trp Glu Ser Phe Asp 
        195                 200                 205             


Val Thr Pro Ala Val Met Arg Trp Thr Ala Gln Gly His Ala Asn His 
    210                 215                 220                 


Gly Phe Val Val Glu Val Ala His Leu Glu Glu Lys Gln Gly Val Ser 
225                 230                 235                 240 


Lys Arg His Val Arg Ile Ser Arg Ser Leu His Gln Asp Glu His Ser 
                245                 250                 255     


Trp Ser Gln Ile Arg Pro Leu Leu Val Thr Phe Gly His Asp Gly Lys 
            260                 265                 270         


Gly His Pro Leu His Lys Arg Glu Lys Arg Gln Ala Lys His Lys Gln 
        275                 280                 285             


Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp 
    290                 295                 300                 


Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr 
305                 310                 315                 320 


His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His 
                325                 330                 335     


Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val 
            340                 345                 350         


Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala 
        355                 360                 365             


Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn 
    370                 375                 380                 


Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
385                 390                 395     


<210>  2315
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  2315

Met Leu Leu Arg Ser Ala Gly Lys Leu Asn Val Gly Thr Lys Lys Glu 
1               5                   10                  15      


Asp Gly Glu Ser Thr Ala Pro Thr Pro Arg Pro Lys Val Leu Arg Cys 
            20                  25                  30          


Lys Cys His His His Cys Pro Glu Asp Ser Val Asn Asn Ile Cys Ser 
        35                  40                  45              


Thr Asp Gly Tyr Cys Phe Thr Met Ile Glu Glu Asp Asp Ser Gly Leu 
    50                  55                  60                  


Pro Val Val Thr Ser Gly Cys Leu Gly Leu Glu Gly Ser Asp Phe Gln 
65                  70                  75                  80  


Cys Arg Asp Thr Pro Ile Pro His Gln Arg Arg Ser Ile Glu Cys Cys 
                85                  90                  95      


Thr Glu Arg Asn Glu Cys Asn Lys Asp Leu His Pro Thr Leu Pro Pro 
            100                 105                 110         


Leu Lys Asn Arg Asp Phe Val Asp Gly Pro Ile His His Arg Ala Leu 
        115                 120                 125             


Leu Ile Ser Val Thr Val Cys Ser Leu Leu Leu Val Leu Ile Ile Leu 
    130                 135                 140                 


Phe Cys Tyr Phe Arg Tyr Lys Arg Gln Glu Thr Arg Pro Arg Tyr Ser 
145                 150                 155                 160 


Ile Gly Leu Glu Gln Asp Glu Thr Tyr Ile Pro Pro Gly Glu Ser Leu 
                165                 170                 175     


Arg Asp Leu Ile Glu Gln Ser Gln Ser Ser Gly Ser Gly Ser Gly Leu 
            180                 185                 190         


Pro Leu Leu Val Gln Arg Thr Ile Ala Lys Gln Ile Gln Met Val Lys 
        195                 200                 205             


Gln Ile Gly Lys Gly Arg Tyr Gly Glu Val Trp Met Gly Lys Trp Arg 
    210                 215                 220                 


Gly Glu Lys Val Ala Val Lys Val Phe Phe Thr Thr Glu Glu Ala Ser 
225                 230                 235                 240 


Trp Phe Arg Glu Thr Glu Ile Tyr Gln Thr Val Leu Met Arg His Glu 
                245                 250                 255     


Asn Ile Leu Gly Phe Ile Ala Ala Asp Ile Lys Gly Thr Gly Ser Trp 
            260                 265                 270         


Thr Gln Leu Tyr Leu Ile Thr Asp Tyr His Glu Asn Gly Ser Leu Tyr 
        275                 280                 285             


Asp Tyr Leu Lys Ser Thr Thr Leu Asp Ala Lys Ser Met Leu Lys Leu 
    290                 295                 300                 


Ala Tyr Ser Ser Val Ser Gly Leu Cys His Leu His Thr Glu Ile Phe 
305                 310                 315                 320 


Ser Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser Lys 
                325                 330                 335     


Asn Ile Leu Val Lys Lys Asn Gly Thr Cys Cys Ile Ala Asp Leu Gly 
            340                 345                 350         


Leu Ala Val Lys Phe Ile Ser Asp Thr Asn Glu Val Asp Ile Pro Pro 
        355                 360                 365             


Asn Thr Arg Val Gly Thr Lys Arg Tyr Met Pro Pro Glu Val Leu Asp 
    370                 375                 380                 


Glu Ser Leu Asn Arg Asn His Phe Gln Ser Tyr Ile Met Ala Asp Met 
385                 390                 395                 400 


Tyr Ser Phe Gly Leu Ile Leu Trp Glu Val Ala Arg Arg Cys Val Ser 
                405                 410                 415     


Gly Gly Ile Val Glu Glu Tyr Gln Leu Pro Tyr His Asp Leu Val Pro 
            420                 425                 430         


Ser Asp Pro Ser Tyr Glu Asp Met Arg Glu Ile Val Cys Ile Lys Lys 
        435                 440                 445             


Leu Arg Pro Ser Phe Pro Asn Arg Trp Ser Ser Asp Glu Cys Leu Arg 
    450                 455                 460                 


Gln Met Gly Lys Leu Met Thr Glu Cys Trp Ala His Asn Pro Ala Ser 
465                 470                 475                 480 


Arg Leu Thr Ala Leu Arg Val Lys Lys Thr Leu Ala Lys Met Ser Glu 
                485                 490                 495     


Ser Gln Asp Ile Lys Leu 
            500         


<210>  2316
<211>  1038
<212>  PRT
<213>  Homo sapiens

<400>  2316

Met Thr Ser Ser Leu Gln Arg Pro Trp Arg Val Pro Trp Leu Pro Trp 
1               5                   10                  15      


Thr Ile Leu Leu Val Ser Thr Ala Ala Ala Ser Gln Asn Gln Glu Arg 
            20                  25                  30          


Leu Cys Ala Phe Lys Asp Pro Tyr Gln Gln Asp Leu Gly Ile Gly Glu 
        35                  40                  45              


Ser Arg Ile Ser His Glu Asn Gly Thr Ile Leu Cys Ser Lys Gly Ser 
    50                  55                  60                  


Thr Cys Tyr Gly Leu Trp Glu Lys Ser Lys Gly Asp Ile Asn Leu Val 
65                  70                  75                  80  


Lys Gln Gly Cys Trp Ser His Ile Gly Asp Pro Gln Glu Cys His Tyr 
                85                  90                  95      


Glu Glu Cys Val Val Thr Thr Thr Pro Pro Ser Ile Gln Asn Gly Thr 
            100                 105                 110         


Tyr Arg Phe Cys Cys Cys Ser Thr Asp Leu Cys Asn Val Asn Phe Thr 
        115                 120                 125             


Glu Asn Phe Pro Pro Pro Asp Thr Thr Pro Leu Ser Pro Pro His Ser 
    130                 135                 140                 


Phe Asn Arg Asp Glu Thr Ile Ile Ile Ala Leu Ala Ser Val Ser Val 
145                 150                 155                 160 


Leu Ala Val Leu Ile Val Ala Leu Cys Phe Gly Tyr Arg Met Leu Thr 
                165                 170                 175     


Gly Asp Arg Lys Gln Gly Leu His Ser Met Asn Met Met Glu Ala Ala 
            180                 185                 190         


Ala Ser Glu Pro Ser Leu Asp Leu Asp Asn Leu Lys Leu Leu Glu Leu 
        195                 200                 205             


Ile Gly Arg Gly Arg Tyr Gly Ala Val Tyr Lys Gly Ser Leu Asp Glu 
    210                 215                 220                 


Arg Pro Val Ala Val Lys Val Phe Ser Phe Ala Asn Arg Gln Asn Phe 
225                 230                 235                 240 


Ile Asn Glu Lys Asn Ile Tyr Arg Val Pro Leu Met Glu His Asp Asn 
                245                 250                 255     


Ile Ala Arg Phe Ile Val Gly Asp Glu Arg Val Thr Ala Asp Gly Arg 
            260                 265                 270         


Met Glu Tyr Leu Leu Val Met Glu Tyr Tyr Pro Asn Gly Ser Leu Cys 
        275                 280                 285             


Lys Tyr Leu Ser Leu His Thr Ser Asp Trp Val Ser Ser Cys Arg Leu 
    290                 295                 300                 


Ala His Ser Val Thr Arg Gly Leu Ala Tyr Leu His Thr Glu Leu Pro 
305                 310                 315                 320 


Arg Gly Asp His Tyr Lys Pro Ala Ile Ser His Arg Asp Leu Asn Ser 
                325                 330                 335     


Arg Asn Val Leu Val Lys Asn Asp Gly Thr Cys Val Ile Ser Asp Phe 
            340                 345                 350         


Gly Leu Ser Met Arg Leu Thr Gly Asn Arg Leu Val Arg Pro Gly Glu 
        355                 360                 365             


Glu Asp Asn Ala Ala Ile Ser Glu Val Gly Thr Ile Arg Tyr Met Ala 
    370                 375                 380                 


Pro Glu Val Leu Glu Gly Ala Val Asn Leu Arg Asp Cys Glu Ser Ala 
385                 390                 395                 400 


Leu Lys Gln Val Asp Met Tyr Ala Leu Gly Leu Ile Tyr Trp Glu Ile 
                405                 410                 415     


Phe Met Arg Cys Thr Asp Leu Phe Pro Gly Glu Ser Val Pro Glu Tyr 
            420                 425                 430         


Gln Met Ala Phe Gln Thr Glu Val Gly Asn His Pro Thr Phe Glu Asp 
        435                 440                 445             


Met Gln Val Leu Val Ser Arg Glu Lys Gln Arg Pro Lys Phe Pro Glu 
    450                 455                 460                 


Ala Trp Lys Glu Asn Ser Leu Ala Val Arg Ser Leu Lys Glu Thr Ile 
465                 470                 475                 480 


Glu Asp Cys Trp Asp Gln Asp Ala Glu Ala Arg Leu Thr Ala Gln Cys 
                485                 490                 495     


Ala Glu Glu Arg Met Ala Glu Leu Met Met Ile Trp Glu Arg Asn Lys 
            500                 505                 510         


Ser Val Ser Pro Thr Val Asn Pro Met Ser Thr Ala Met Gln Asn Glu 
        515                 520                 525             


Arg Asn Leu Ser His Asn Arg Arg Val Pro Lys Ile Gly Pro Tyr Pro 
    530                 535                 540                 


Asp Tyr Ser Ser Ser Ser Tyr Ile Glu Asp Ser Ile His His Thr Asp 
545                 550                 555                 560 


Ser Ile Val Lys Asn Ile Ser Ser Glu His Ser Met Ser Ser Thr Pro 
                565                 570                 575     


Leu Thr Ile Gly Glu Lys Asn Arg Asn Ser Ile Asn Tyr Glu Arg Gln 
            580                 585                 590         


Gln Ala Gln Ala Arg Ile Pro Ser Pro Glu Thr Ser Val Thr Ser Leu 
        595                 600                 605             


Ser Thr Asn Thr Thr Thr Thr Asn Thr Thr Gly Leu Thr Pro Ser Thr 
    610                 615                 620                 


Gly Met Thr Thr Ile Ser Glu Met Pro Tyr Pro Asp Glu Thr Asn Leu 
625                 630                 635                 640 


His Thr Thr Asn Val Ala Gln Ser Ile Gly Pro Thr Pro Val Cys Leu 
                645                 650                 655     


Gln Leu Thr Glu Glu Asp Leu Glu Thr Asn Lys Leu Asp Pro Lys Glu 
            660                 665                 670         


Val Asp Lys Asn Leu Lys Glu Ser Ser Asp Glu Asn Leu Met Glu His 
        675                 680                 685             


Ser Leu Lys Gln Phe Ser Gly Pro Asp Pro Leu Ser Ser Thr Ser Ser 
    690                 695                 700                 


Ser Leu Leu Tyr Pro Leu Ile Lys Leu Ala Val Glu Ala Thr Gly Gln 
705                 710                 715                 720 


Gln Asp Phe Thr Gln Thr Ala Asn Gly Gln Ala Cys Leu Ile Pro Asp 
                725                 730                 735     


Val Leu Pro Thr Gln Ile Tyr Pro Leu Pro Lys Gln Gln Asn Leu Pro 
            740                 745                 750         


Lys Arg Pro Thr Ser Leu Pro Leu Asn Thr Lys Asn Ser Thr Lys Glu 
        755                 760                 765             


Pro Arg Leu Lys Phe Gly Ser Lys His Lys Ser Asn Leu Lys Gln Val 
    770                 775                 780                 


Glu Thr Gly Val Ala Lys Met Asn Thr Ile Asn Ala Ala Glu Pro His 
785                 790                 795                 800 


Val Val Thr Val Thr Met Asn Gly Val Ala Gly Arg Asn His Ser Val 
                805                 810                 815     


Asn Ser His Ala Ala Thr Thr Gln Tyr Ala Asn Gly Thr Val Leu Ser 
            820                 825                 830         


Gly Gln Thr Thr Asn Ile Val Thr His Arg Ala Gln Glu Met Leu Gln 
        835                 840                 845             


Asn Gln Phe Ile Gly Glu Asp Thr Arg Leu Asn Ile Asn Ser Ser Pro 
    850                 855                 860                 


Asp Glu His Glu Pro Leu Leu Arg Arg Glu Gln Gln Ala Gly His Asp 
865                 870                 875                 880 


Glu Gly Val Leu Asp Arg Leu Val Asp Arg Arg Glu Arg Pro Leu Glu 
                885                 890                 895     


Gly Gly Arg Thr Asn Ser Asn Asn Asn Asn Ser Asn Pro Cys Ser Glu 
            900                 905                 910         


Gln Asp Val Leu Ala Gln Gly Val Pro Ser Thr Ala Ala Asp Pro Gly 
        915                 920                 925             


Pro Ser Lys Pro Arg Arg Ala Gln Arg Pro Asn Ser Leu Asp Leu Ser 
    930                 935                 940                 


Ala Thr Asn Val Leu Asp Gly Ser Ser Ile Gln Ile Gly Glu Ser Thr 
945                 950                 955                 960 


Gln Asp Gly Lys Ser Gly Ser Gly Glu Lys Ile Lys Lys Arg Val Lys 
                965                 970                 975     


Thr Pro Tyr Ser Leu Lys Arg Trp Arg Pro Ser Thr Trp Val Ile Ser 
            980                 985                 990         


Thr Glu Ser Leu Asp Cys Glu Val  Asn Asn Asn Gly Ser  Asn Arg Ala 
        995                 1000                 1005             


Val His  Ser Lys Ser Ser Thr  Ala Val Tyr Leu Ala  Glu Gly Gly 
    1010                 1015                 1020             


Thr Ala  Thr Thr Met Val Ser  Lys Asp Ile Gly Met  Asn Cys Leu 
    1025                 1030                 1035             


<210>  2317
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  2317

Met Ala Ala Pro Gln Asp Val His Val Arg Ile Cys Asn Gln Glu Ile 
1               5                   10                  15      


Val Lys Phe Asp Leu Glu Val Lys Ala Leu Ile Gln Asp Ile Arg Asp 
            20                  25                  30          


Cys Ser Gly Pro Leu Ser Ala Leu Thr Glu Leu Asn Thr Lys Val Lys 
        35                  40                  45              


Glu Lys Phe Gln Gln Leu Arg His Arg Ile Gln Asp Leu Glu Gln Leu 
    50                  55                  60                  


Ala Lys Glu Gln Asp Lys Glu Ser Glu Lys Gln Leu Leu Leu Gln Glu 
65                  70                  75                  80  


Val Glu Asn His Lys Lys Gln Met Leu Ser Asn Gln Ala Ser Trp Arg 
                85                  90                  95      


Lys Ala Asn Leu Thr Cys Lys Ile Ala Ile Asp Asn Leu Glu Lys Ala 
            100                 105                 110         


Glu Leu Leu Gln Gly Gly Asp Leu Leu Arg Gln Arg Lys Thr Thr Lys 
        115                 120                 125             


Glu Ser Leu Ala Gln Thr Ser Ser Thr Ile Thr Glu Ser Leu Met Gly 
    130                 135                 140                 


Ile Ser Arg Met Met Ala Gln Gln Val Gln Gln Ser Glu Glu Ala Met 
145                 150                 155                 160 


Gln Ser Leu Val Thr Ser Ser Arg Thr Ile Leu Asp Ala Asn Glu Glu 
                165                 170                 175     


Phe Lys Ser Met Ser Gly Thr Ile Gln Leu Gly Arg Lys Leu Ile Thr 
            180                 185                 190         


Lys Tyr Asn Arg Arg Glu Leu Thr Asp Lys Leu Leu Ile Phe Leu Ala 
        195                 200                 205             


Leu Ala Leu Phe Leu Ala Thr Val Leu Tyr Ile Val Lys Lys Arg Leu 
    210                 215                 220                 


Phe Pro Phe Leu 
225             


<210>  2318
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  2318

Met Ala Pro Leu Cys Pro Ser Pro Trp Leu Pro Leu Leu Ile Pro Ala 
1               5                   10                  15      


Pro Ala Pro Gly Leu Thr Val Gln Leu Leu Leu Ser Leu Leu Leu Leu 
            20                  25                  30          


Val Pro Val His Pro Gln Arg Leu Pro Arg Met Gln Glu Asp Ser Pro 
        35                  40                  45              


Leu Gly Gly Gly Ser Ser Gly Glu Asp Asp Pro Leu Gly Glu Glu Asp 
    50                  55                  60                  


Leu Pro Ser Glu Glu Asp Ser Pro Arg Glu Glu Asp Pro Pro Gly Glu 
65                  70                  75                  80  


Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro 
                85                  90                  95      


Glu Val Lys Pro Lys Ser Glu Glu Glu Gly Ser Leu Lys Leu Glu Asp 
            100                 105                 110         


Leu Pro Thr Val Glu Ala Pro Gly Asp Pro Gln Glu Pro Gln Asn Asn 
        115                 120                 125             


Ala His Arg Asp Lys Glu Gly Asp Asp Gln Ser His Trp Arg Tyr Gly 
    130                 135                 140                 


Gly Asp Pro Pro Trp Pro Arg Val Ser Pro Ala Cys Ala Gly Arg Phe 
145                 150                 155                 160 


Gln Ser Pro Val Asp Ile Arg Pro Gln Leu Ala Ala Phe Cys Pro Ala 
                165                 170                 175     


Leu Arg Pro Leu Glu Leu Leu Gly Phe Gln Leu Pro Pro Leu Pro Glu 
            180                 185                 190         


Leu Arg Leu Arg Asn Asn Gly His Ser Val Gln Leu Thr Leu Pro Pro 
        195                 200                 205             


Gly Leu Glu Met Ala Leu Gly Pro Gly Arg Glu Tyr Arg Ala Leu Gln 
    210                 215                 220                 


Leu His Leu His Trp Gly Ala Ala Gly Arg Pro Gly Ser Glu His Thr 
225                 230                 235                 240 


Val Glu Gly His Arg Phe Pro Ala Glu Ile His Val Val His Leu Ser 
                245                 250                 255     


Thr Ala Phe Ala Arg Val Asp Glu Ala Leu Gly Arg Pro Gly Gly Leu 
            260                 265                 270         


Ala Val Leu Ala Ala Phe Leu Glu Glu Gly Pro Glu Glu Asn Ser Ala 
        275                 280                 285             


Tyr Glu Gln Leu Leu Ser Arg Leu Glu Glu Ile Ala Glu Glu Gly Ser 
    290                 295                 300                 


Glu Thr Gln Val Pro Gly Leu Asp Ile Ser Ala Leu Leu Pro Ser Asp 
305                 310                 315                 320 


Phe Ser Arg Tyr Phe Gln Tyr Glu Gly Ser Leu Thr Thr Pro Pro Cys 
                325                 330                 335     


Ala Gln Gly Val Ile Trp Thr Val Phe Asn Gln Thr Val Met Leu Ser 
            340                 345                 350         


Ala Lys Gln Leu His Thr Leu Ser Asp Thr Leu Trp Gly Pro Gly Asp 
        355                 360                 365             


Ser Arg Leu Gln Leu Asn Phe Arg Ala Thr Gln Pro Leu Asn Gly Arg 
    370                 375                 380                 


Val Ile Glu Ala Ser Phe Pro Ala Gly Val Asp Ser Ser Pro Arg Ala 
385                 390                 395                 400 


Ala Glu Pro Val Gln Leu Asn Ser Cys Leu Ala Ala Gly Asp Ile Leu 
                405                 410                 415     


Ala Leu Val Phe Gly Leu Leu Phe Ala Val Thr Ser Val Ala Phe Leu 
            420                 425                 430         


Val Gln Met Arg Arg Gln His Arg Arg Gly Thr Lys Gly Gly Val Ser 
        435                 440                 445             


Tyr Arg Pro Ala Glu Val Ala Glu Thr Gly Ala 
    450                 455                 


<210>  2319
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  2319

Met Pro Arg Arg Ser Leu His Ala Ala Ala Val Leu Leu Leu Val Ile 
1               5                   10                  15      


Leu Lys Glu Gln Pro Ser Ser Pro Ala Pro Val Asn Gly Ser Lys Trp 
            20                  25                  30          


Thr Tyr Phe Gly Pro Asp Gly Glu Asn Ser Trp Ser Lys Lys Tyr Pro 
        35                  40                  45              


Ser Cys Gly Gly Leu Leu Gln Ser Pro Ile Asp Leu His Ser Asp Ile 
    50                  55                  60                  


Leu Gln Tyr Asp Ala Ser Leu Thr Pro Leu Glu Phe Gln Gly Tyr Asn 
65                  70                  75                  80  


Leu Ser Ala Asn Lys Gln Phe Leu Leu Thr Asn Asn Gly His Ser Val 
                85                  90                  95      


Lys Leu Asn Leu Pro Ser Asp Met His Ile Gln Gly Leu Gln Ser Arg 
            100                 105                 110         


Tyr Ser Ala Thr Gln Leu His Leu His Trp Gly Asn Pro Asn Asp Pro 
        115                 120                 125             


His Gly Ser Glu His Thr Val Ser Gly Gln His Phe Ala Ala Glu Leu 
    130                 135                 140                 


His Ile Val His Tyr Asn Ser Asp Leu Tyr Pro Asp Ala Ser Thr Ala 
145                 150                 155                 160 


Ser Asn Lys Ser Glu Gly Leu Ala Val Leu Ala Val Leu Ile Glu Met 
                165                 170                 175     


Gly Ser Phe Asn Pro Ser Tyr Asp Lys Ile Phe Ser His Leu Gln His 
            180                 185                 190         


Val Lys Tyr Lys Gly Gln Glu Ala Phe Val Pro Gly Phe Asn Ile Glu 
        195                 200                 205             


Glu Leu Leu Pro Glu Arg Thr Ala Glu Tyr Tyr Arg Tyr Arg Gly Ser 
    210                 215                 220                 


Leu Thr Thr Pro Pro Cys Asn Pro Thr Val Leu Trp Thr Val Phe Arg 
225                 230                 235                 240 


Asn Pro Val Gln Ile Ser Gln Glu Gln Leu Leu Ala Leu Glu Thr Ala 
                245                 250                 255     


Leu Tyr Cys Thr His Met Asp Asp Pro Ser Pro Arg Glu Met Ile Asn 
            260                 265                 270         


Asn Phe Arg Gln Val Gln Lys Phe Asp Glu Arg Leu Val Tyr Thr Ser 
        275                 280                 285             


Phe Ser Gln Val Gln Val Cys Thr Ala Ala Gly Leu Ser Leu Gly Ile 
    290                 295                 300                 


Ile Leu Ser Leu Ala Leu Ala Gly Ile Leu Gly Ile Cys Ile Val Val 
305                 310                 315                 320 


Val Val Ser Ile Trp Leu Phe Arg Arg Lys Ser Ile Lys Lys Gly Asp 
                325                 330                 335     


Asn Lys Gly Val Ile Tyr Lys Pro Ala Thr Lys Met Glu Thr Glu Ala 
            340                 345                 350         


His Ala 
        


<210>  2320
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  2320

Met Gly Leu Glu Thr Glu Lys Ala Asp Val Gln Leu Phe Met Asp Asp 
1               5                   10                  15      


Asp Ser Tyr Ser His His Ser Gly Leu Glu Tyr Ala Asp Pro Glu Lys 
            20                  25                  30          


Phe Ala Asp Ser Asp Gln Asp Arg Asp Pro His Arg Leu Asn Ser His 
        35                  40                  45              


Leu Lys Leu Gly Phe Glu Asp Val Ile Ala Glu Pro Val Thr Thr His 
    50                  55                  60                  


Ser Phe Asp Lys Val Trp Ile Cys Ser His Ala Leu Phe Glu Ile Ser 
65                  70                  75                  80  


Lys Tyr Val Met Tyr Lys Phe Leu Thr Val Phe Leu Ala Ile Pro Leu 
                85                  90                  95      


Ala Phe Ile Ala Gly Ile Leu Phe Ala Thr Leu Ser Cys Leu His Ile 
            100                 105                 110         


Trp Ile Leu Met Pro Phe Val Lys Thr Cys Leu Met Val Leu Pro Ser 
        115                 120                 125             


Val Gln Thr Ile Trp Lys Ser Val Thr Asp Val Ile Ile Ala Pro Leu 
    130                 135                 140                 


Cys Thr Ser Val Gly Arg Cys Phe Ser Ser Val Ser Leu Gln Leu Ser 
145                 150                 155                 160 


Gln Asp 
        


<210>  2321
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  2321

Met Met Ala Glu Glu His Thr Asp Leu Glu Ala Gln Ile Val Lys Asp 
1               5                   10                  15      


Ile His Cys Lys Glu Ile Asp Leu Val Asn Arg Asp Pro Lys Asn Ile 
            20                  25                  30          


Asn Glu Asp Ile Val Lys Val Asp Phe Glu Asp Val Ile Ala Glu Pro 
        35                  40                  45              


Val Gly Thr Tyr Ser Phe Asp Gly Val Trp Lys Val Ser Tyr Thr Thr 
    50                  55                  60                  


Phe Thr Val Ser Lys Tyr Trp Cys Tyr Arg Leu Leu Ser Thr Leu Leu 
65                  70                  75                  80  


Gly Val Pro Leu Ala Leu Leu Trp Gly Phe Leu Phe Ala Cys Ile Ser 
                85                  90                  95      


Phe Cys His Ile Trp Ala Val Val Pro Cys Ile Lys Ser Tyr Leu Ile 
            100                 105                 110         


Glu Ile Gln Cys Ile Ser His Ile Tyr Ser Leu Cys Ile Arg Thr Phe 
        115                 120                 125             


Cys Asn Pro Leu Phe Ala Ala Leu Gly Gln Val Cys Ser Ser Ile Lys 
    130                 135                 140                 


Val Val Leu Arg Lys Glu Val 
145                 150     


<210>  2322
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  2322

Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile 
            180                 185                 190         


Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala 
        195                 200                 205             


Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser 
    210                 215                 220                 


Pro Val Glu Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu 
225                 230                 235                 240 


Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro 
                245                 250                 255     


Ala Cys Ser Pro 
            260 


<210>  2323
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  2323

Met Arg Val Leu Leu Ala Ala Leu Gly Leu Leu Phe Leu Gly Ala Leu 
1               5                   10                  15      


Arg Ala Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn 
            20                  25                  30          


Pro Ser His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys 
        35                  40                  45              


Pro Met Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp 
    50                  55                  60                  


Cys Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg 
65                  70                  75                  80  


Cys Thr Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr 
                85                  90                  95      


Pro Cys Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met 
            100                 105                 110         


Phe Cys Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His 
        115                 120                 125             


Ser Val Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln 
    130                 135                 140                 


Lys Asn Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys 
145                 150                 155                 160 


Ala Ser Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln 
                165                 170                 175     


Ala Lys Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met 
            180                 185                 190         


Pro Val Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu 
        195                 200                 205             


Thr Arg Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp 
    210                 215                 220                 


Pro Gly Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys 
225                 230                 235                 240 


Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys 
                245                 250                 255     


Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro 
            260                 265                 270         


Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile 
        275                 280                 285             


Cys Ala Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro 
    290                 295                 300                 


Ile Cys Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys 
305                 310                 315                 320 


Asp Thr Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn 
                325                 330                 335     


Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln 
            340                 345                 350         


Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr 
        355                 360                 365             


Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala 
    370                 375                 380                 


Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly 
385                 390                 395                 400 


Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile 
                405                 410                 415     


Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys 
            420                 425                 430         


Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg 
        435                 440                 445             


Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met 
    450                 455                 460                 


Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu 
465                 470                 475                 480 


Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser 
                485                 490                 495     


Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn 
            500                 505                 510         


Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly 
        515                 520                 525             


Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala 
    530                 535                 540                 


Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr 
545                 550                 555                 560 


Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met 
                565                 570                 575     


Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala 
            580                 585                 590         


Ser Gly Lys 
        595 


<210>  2324
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  2324

Met Asp Pro Gly Leu Gln Gln Ala Leu Asn Gly Met Ala Pro Pro Gly 
1               5                   10                  15      


Asp Thr Ala Met His Val Pro Ala Gly Ser Val Ala Ser His Leu Gly 
            20                  25                  30          


Thr Thr Ser Arg Ser Tyr Phe Tyr Leu Thr Thr Ala Thr Leu Ala Leu 
        35                  40                  45              


Cys Leu Val Phe Thr Val Ala Thr Ile Met Val Leu Val Val Gln Arg 
    50                  55                  60                  


Thr Asp Ser Ile Pro Asn Ser Pro Asp Asn Val Pro Leu Lys Gly Gly 
65                  70                  75                  80  


Asn Cys Ser Glu Asp Leu Leu Cys Ile Leu Lys Arg Ala Pro Phe Lys 
                85                  90                  95      


Lys Ser Trp Ala Tyr Leu Gln Val Ala Lys His Leu Asn Lys Thr Lys 
            100                 105                 110         


Leu Ser Trp Asn Lys Asp Gly Ile Leu His Gly Val Arg Tyr Gln Asp 
        115                 120                 125             


Gly Asn Leu Val Ile Gln Phe Pro Gly Leu Tyr Phe Ile Ile Cys Gln 
    130                 135                 140                 


Leu Gln Phe Leu Val Gln Cys Pro Asn Asn Ser Val Asp Leu Lys Leu 
145                 150                 155                 160 


Glu Leu Leu Ile Asn Lys His Ile Lys Lys Gln Ala Leu Val Thr Val 
                165                 170                 175     


Cys Glu Ser Gly Met Gln Thr Lys His Val Tyr Gln Asn Leu Ser Gln 
            180                 185                 190         


Phe Leu Leu Asp Tyr Leu Gln Val Asn Thr Thr Ile Ser Val Asn Val 
        195                 200                 205             


Asp Thr Phe Gln Tyr Ile Asp Thr Ser Thr Phe Pro Leu Glu Asn Val 
    210                 215                 220                 


Leu Ser Ile Phe Leu Tyr Ser Asn Ser Asp 
225                 230                 


<210>  2325
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  2325

Met Gln Gly Ala Gln Glu Ala Ser Ala Ser Glu Met Leu Pro Leu Leu 
1               5                   10                  15      


Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala Gln Glu Arg Arg Phe Gln 
            20                  25                  30          


Leu Glu Gly Pro Glu Ser Leu Thr Val Gln Glu Gly Leu Cys Val Leu 
        35                  40                  45              


Val Pro Cys Arg Leu Pro Thr Thr Leu Pro Ala Ser Tyr Tyr Gly Tyr 
    50                  55                  60                  


Gly Tyr Trp Phe Leu Glu Gly Ala Asp Val Pro Val Ala Thr Asn Asp 
65                  70                  75                  80  


Pro Asp Glu Glu Val Gln Glu Glu Thr Arg Gly Arg Phe His Leu Leu 
                85                  90                  95      


Trp Asp Pro Arg Arg Lys Asn Cys Ser Leu Ser Ile Arg Asp Ala Arg 
            100                 105                 110         


Arg Arg Asp Asn Ala Ala Tyr Phe Phe Arg Leu Lys Ser Lys Trp Met 
        115                 120                 125             


Lys Tyr Gly Tyr Thr Ser Ser Lys Leu Ser Val Arg Val Met Ala Leu 
    130                 135                 140                 


Thr His Arg Pro Asn Ile Ser Ile Pro Gly Thr Leu Glu Ser Gly His 
145                 150                 155                 160 


Pro Ser Asn Leu Thr Cys Ser Val Pro Trp Val Cys Glu Gln Gly Thr 
                165                 170                 175     


Pro Pro Ile Phe Ser Trp Met Ser Ala Ala Pro Thr Ser Leu Gly Pro 
            180                 185                 190         


Arg Thr Thr Gln Ser Ser Val Leu Thr Ile Thr Pro Arg Pro Gln Asp 
        195                 200                 205             


His Ser Thr Asn Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Gly Val 
    210                 215                 220                 


Thr Met Glu Arg Thr Ile Gln Leu Asn Val Ser Tyr Ala Pro Gln Lys 
225                 230                 235                 240 


Val Ala Ile Ser Ile Phe Gln Gly Asn Ser Ala Ala Phe Lys Ile Leu 
                245                 250                 255     


Gln Asn Thr Ser Ser Leu Pro Val Leu Glu Gly Gln Ala Leu Arg Leu 
            260                 265                 270         


Leu Cys Asp Ala Asp Gly Asn Pro Pro Ala His Leu Ser Trp Phe Gln 
        275                 280                 285             


Gly Phe Pro Ala Leu Asn Ala Thr Pro Ile Ser Asn Thr Gly Val Leu 
    290                 295                 300                 


Glu Leu Pro Gln Val Gly Ser Ala Glu Glu Gly Asp Phe Thr Cys Arg 
305                 310                 315                 320 


Ala Gln His Pro Leu Gly Ser Leu Gln Ile Ser Leu Ser Leu Phe Val 
                325                 330                 335     


His Trp Lys Pro Glu Gly Arg Ala Gly Gly Val Leu Gly Ala Val Trp 
            340                 345                 350         


Gly Ala Ser Ile Thr Thr Leu Val Phe Leu Cys Val Cys Phe Ile Phe 
        355                 360                 365             


Arg Val Lys Thr Arg Arg Lys Lys Ala Ala Gln Pro Val Gln Asn Thr 
    370                 375                 380                 


Asp Asp Val Asn Pro Val Met Val Ser Gly Ser Arg Gly His Gln His 
385                 390                 395                 400 


Gln Phe Gln Thr Gly Ile Val Ser Asp His Pro Ala Glu Ala Gly Pro 
                405                 410                 415     


Ile Ser Glu Asp Glu Gln Glu Leu His Tyr Ala Val Leu His Phe His 
            420                 425                 430         


Lys Val Gln Pro Gln Glu Pro Lys Val Thr Asp Thr Glu Tyr Ser Glu 
        435                 440                 445             


Ile Lys Ile His Lys 
    450             


<210>  2326
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  2326

Met Ala Gly Lys Val Arg Ser Leu Leu Pro Pro Leu Leu Leu Ala Ala 
1               5                   10                  15      


Ala Gly Leu Ala Gly Leu Leu Leu Leu Cys Val Pro Thr Arg Asp Val 
            20                  25                  30          


Arg Glu Pro Pro Ala Leu Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser 
        35                  40                  45              


Ser His Thr Ser Met Phe Ile Tyr Lys Trp Pro Ala Asp Lys Glu Asn 
    50                  55                  60                  


Asp Thr Gly Ile Val Gly Gln His Ser Ser Cys Asp Val Pro Gly Gly 
65                  70                  75                  80  


Gly Ile Ser Ser Tyr Ala Asp Asn Pro Ser Gly Ala Ser Gln Ser Leu 
                85                  90                  95      


Val Gly Cys Leu Glu Gln Ala Leu Gln Asp Val Pro Lys Glu Arg His 
            100                 105                 110         


Ala Gly Thr Pro Leu Tyr Leu Gly Ala Thr Ala Gly Met Arg Leu Leu 
        115                 120                 125             


Asn Leu Thr Asn Pro Glu Ala Ser Thr Ser Val Leu Met Ala Val Thr 
    130                 135                 140                 


His Thr Leu Thr Gln Tyr Pro Phe Asp Phe Arg Gly Ala Arg Ile Leu 
145                 150                 155                 160 


Ser Gly Gln Glu Glu Gly Val Phe Gly Trp Val Thr Ala Asn Tyr Leu 
                165                 170                 175     


Leu Glu Asn Phe Ile Lys Tyr Gly Trp Val Gly Arg Trp Phe Arg Pro 
            180                 185                 190         


Arg Lys Gly Thr Leu Gly Ala Met Asp Leu Gly Gly Ala Ser Thr Gln 
        195                 200                 205             


Ile Thr Phe Glu Thr Thr Ser Pro Ala Glu Asp Arg Ala Ser Glu Val 
    210                 215                 220                 


Gln Leu His Leu Tyr Gly Gln His Tyr Arg Val Tyr Thr His Ser Phe 
225                 230                 235                 240 


Leu Cys Tyr Gly Arg Asp Gln Val Leu Gln Arg Leu Leu Ala Ser Ala 
                245                 250                 255     


Leu Gln Thr His Gly Phe His Pro Cys Trp Pro Arg Gly Phe Ser Thr 
            260                 265                 270         


Gln Val Leu Leu Gly Asp Val Tyr Gln Ser Pro Cys Thr Met Ala Gln 
        275                 280                 285             


Arg Pro Gln Asn Phe Asn Ser Ser Ala Arg Val Ser Leu Ser Gly Ser 
    290                 295                 300                 


Ser Asp Pro His Leu Cys Arg Asp Leu Val Ser Gly Leu Phe Ser Phe 
305                 310                 315                 320 


Ser Ser Cys Pro Phe Ser Arg Cys Ser Phe Asn Gly Val Phe Gln Pro 
                325                 330                 335     


Pro Val Ala Gly Asn Phe Val Ala Phe Ser Ala Phe Phe Tyr Thr Val 
            340                 345                 350         


Asp Phe Leu Arg Thr Ser Met Gly Leu Pro Val Ala Thr Leu Gln Gln 
        355                 360                 365             


Leu Glu Ala Ala Ala Val Asn Val Cys Asn Gln Thr Trp Ala Gln Gln 
    370                 375                 380                 


Leu Leu Ser Arg Gly Tyr Gly Phe Asp Glu Arg Ala Phe Gly Gly Val 
385                 390                 395                 400 


Ile Phe Gln Lys Lys Ala Ala Asp Thr Ala Val Gly Trp Ala Leu Gly 
                405                 410                 415     


Tyr Met Leu Asn Leu Thr Asn Leu Ile Pro Ala Asp Pro Pro Gly Leu 
            420                 425                 430         


Arg Lys Gly Thr Asp Phe Ser Ser Trp Val Val Leu Leu Leu Leu Phe 
        435                 440                 445             


Ala Ser Ala Leu Leu Ala Ala Leu Val Leu Leu Leu Arg Gln Val His 
    450                 455                 460                 


Ser Ala Lys Leu Pro Ser Thr Ile 
465                 470         


<210>  2327
<211>  484
<212>  PRT
<213>  Homo sapiens

<400>  2327

Met Lys Lys Gly Ile Arg Tyr Glu Thr Ser Arg Lys Thr Ser Tyr Ile 
1               5                   10                  15      


Phe Gln Gln Pro Gln His Gly Pro Trp Gln Thr Arg Met Arg Lys Ile 
            20                  25                  30          


Ser Asn His Gly Ser Leu Arg Val Ala Lys Val Ala Tyr Pro Leu Gly 
        35                  40                  45              


Leu Cys Val Gly Val Phe Ile Tyr Val Ala Tyr Ile Lys Trp His Arg 
    50                  55                  60                  


Ala Thr Ala Thr Gln Ala Phe Phe Ser Ile Thr Arg Ala Ala Pro Gly 
65                  70                  75                  80  


Ala Arg Trp Gly Gln Gln Ala His Ser Pro Leu Gly Thr Ala Ala Asp 
                85                  90                  95      


Gly His Glu Val Phe Tyr Gly Ile Met Phe Asp Ala Gly Ser Thr Gly 
            100                 105                 110         


Thr Arg Val His Val Phe Gln Phe Thr Arg Pro Pro Arg Glu Thr Pro 
        115                 120                 125             


Thr Leu Thr His Glu Thr Phe Lys Ala Leu Lys Pro Gly Leu Ser Ala 
    130                 135                 140                 


Tyr Ala Asp Asp Val Glu Lys Ser Ala Gln Gly Ile Arg Glu Leu Leu 
145                 150                 155                 160 


Asp Val Ala Lys Gln Asp Ile Pro Phe Asp Phe Trp Lys Ala Thr Pro 
                165                 170                 175     


Leu Val Leu Lys Ala Thr Ala Gly Leu Arg Leu Leu Pro Gly Glu Lys 
            180                 185                 190         


Ala Gln Lys Leu Leu Gln Lys Val Lys Glu Val Phe Lys Ala Ser Pro 
        195                 200                 205             


Phe Leu Val Gly Asp Asp Cys Val Ser Ile Met Asn Gly Thr Asp Glu 
    210                 215                 220                 


Gly Val Ser Ala Trp Ile Thr Ile Asn Phe Leu Thr Gly Ser Leu Lys 
225                 230                 235                 240 


Thr Pro Gly Gly Ser Ser Val Gly Met Leu Asp Leu Gly Gly Gly Ser 
                245                 250                 255     


Thr Gln Ile Ala Phe Leu Pro Arg Val Glu Gly Thr Leu Gln Ala Ser 
            260                 265                 270         


Pro Pro Gly Tyr Leu Thr Ala Leu Arg Met Phe Asn Arg Thr Tyr Lys 
        275                 280                 285             


Leu Tyr Ser Tyr Ser Tyr Leu Gly Leu Gly Leu Met Ser Ala Arg Leu 
    290                 295                 300                 


Ala Ile Leu Gly Gly Val Glu Gly Gln Pro Ala Lys Asp Gly Lys Glu 
305                 310                 315                 320 


Leu Val Ser Pro Cys Leu Ser Pro Ser Phe Lys Gly Glu Trp Glu His 
                325                 330                 335     


Ala Glu Val Thr Tyr Arg Val Ser Gly Gln Lys Ala Ala Ala Ser Leu 
            340                 345                 350         


His Glu Leu Cys Ala Ala Arg Val Ser Glu Val Leu Gln Asn Arg Val 
        355                 360                 365             


His Arg Thr Glu Glu Val Lys His Val Asp Phe Tyr Ala Phe Ser Tyr 
    370                 375                 380                 


Tyr Tyr Asp Leu Ala Ala Gly Val Gly Leu Ile Asp Ala Glu Lys Gly 
385                 390                 395                 400 


Gly Ser Leu Val Val Gly Asp Phe Glu Ile Ala Ala Lys Tyr Val Cys 
                405                 410                 415     


Arg Thr Leu Glu Thr Gln Pro Gln Ser Ser Pro Phe Ser Cys Met Asp 
            420                 425                 430         


Leu Thr Tyr Val Ser Leu Leu Leu Gln Glu Phe Gly Phe Pro Arg Ser 
        435                 440                 445             


Lys Val Leu Lys Leu Thr Arg Lys Ile Asp Asn Val Glu Thr Ser Trp 
    450                 455                 460                 


Ala Leu Gly Ala Ile Phe His Tyr Ile Asp Ser Leu Asn Arg Gln Lys 
465                 470                 475                 480 


Ser Pro Ala Ser 
                


<210>  2328
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  2328

Met Phe Thr Val Leu Thr Arg Gln Pro Cys Glu Gln Ala Gly Leu Lys 
1               5                   10                  15      


Ala Leu Tyr Arg Thr Pro Thr Ile Ile Ala Leu Val Val Leu Leu Val 
            20                  25                  30          


Ser Ile Val Val Leu Val Ser Ile Thr Val Ile Gln Ile His Lys Gln 
        35                  40                  45              


Glu Val Leu Pro Pro Gly Leu Lys Tyr Gly Ile Val Leu Asp Ala Gly 
    50                  55                  60                  


Ser Ser Arg Thr Thr Val Tyr Val Tyr Gln Trp Pro Ala Glu Lys Glu 
65                  70                  75                  80  


Asn Asn Thr Gly Val Val Ser Gln Thr Phe Lys Cys Ser Val Lys Gly 
                85                  90                  95      


Ser Gly Ile Ser Ser Tyr Gly Asn Asn Pro Gln Asp Val Pro Arg Ala 
            100                 105                 110         


Phe Glu Glu Cys Met Gln Lys Val Lys Gly Gln Val Pro Ser His Leu 
        115                 120                 125             


His Gly Ser Thr Pro Ile His Leu Gly Ala Thr Ala Gly Met Arg Leu 
    130                 135                 140                 


Leu Arg Leu Gln Asn Glu Thr Ala Ala Asn Glu Val Leu Glu Ser Ile 
145                 150                 155                 160 


Gln Ser Tyr Phe Lys Ser Gln Pro Phe Asp Phe Arg Gly Ala Gln Ile 
                165                 170                 175     


Ile Ser Gly Gln Glu Glu Gly Val Tyr Gly Trp Ile Thr Ala Asn Tyr 
            180                 185                 190         


Leu Met Gly Asn Phe Leu Glu Lys Asn Leu Trp His Met Trp Val His 
        195                 200                 205             


Pro His Gly Val Glu Thr Thr Gly Ala Leu Asp Leu Gly Gly Ala Ser 
    210                 215                 220                 


Thr Gln Ile Ser Phe Val Ala Gly Glu Lys Met Asp Leu Asn Thr Ser 
225                 230                 235                 240 


Asp Ile Met Gln Val Ser Leu Tyr Gly Tyr Val Tyr Thr Leu Tyr Thr 
                245                 250                 255     


His Ser Phe Gln Cys Tyr Gly Arg Asn Glu Ala Glu Lys Lys Phe Leu 
            260                 265                 270         


Ala Met Leu Leu Gln Asn Ser Pro Thr Lys Asn His Leu Thr Asn Pro 
        275                 280                 285             


Cys Tyr Pro Arg Asp Tyr Ser Ile Ser Phe Thr Met Gly His Val Phe 
    290                 295                 300                 


Asp Ser Leu Cys Thr Val Asp Gln Arg Pro Glu Ser Tyr Asn Pro Asn 
305                 310                 315                 320 


Asp Val Ile Thr Phe Glu Gly Thr Gly Asp Pro Ser Leu Cys Lys Glu 
                325                 330                 335     


Lys Val Ala Ser Ile Phe Asp Phe Lys Ala Cys His Asp Gln Glu Thr 
            340                 345                 350         


Cys Ser Phe Asp Gly Val Tyr Gln Pro Lys Ile Lys Gly Pro Phe Val 
        355                 360                 365             


Ala Phe Ala Gly Phe Tyr Tyr Thr Ala Ser Ala Leu Asn Leu Ser Gly 
    370                 375                 380                 


Ser Phe Ser Leu Asp Thr Phe Asn Ser Ser Thr Trp Asn Phe Cys Ser 
385                 390                 395                 400 


Gln Asn Trp Ser Gln Leu Pro Leu Leu Leu Pro Lys Phe Asp Glu Val 
                405                 410                 415     


Tyr Ala Arg Ser Tyr Cys Phe Ser Ala Asn Tyr Ile Tyr His Leu Phe 
            420                 425                 430         


Val Asn Gly Tyr Lys Phe Thr Glu Glu Thr Trp Pro Gln Ile His Phe 
        435                 440                 445             


Glu Lys Glu Val Gly Asn Ser Ser Ile Ala Trp Ser Leu Gly Tyr Met 
    450                 455                 460                 


Leu Ser Leu Thr Asn Gln Ile Pro Ala Glu Ser Pro Leu Ile Arg Leu 
465                 470                 475                 480 


Pro Ile Glu Pro Pro Val Phe Val Gly Thr Leu Ala Phe Phe Thr Ala 
                485                 490                 495     


Ala Ala Leu Leu Cys Leu Ala Phe Leu Ala Tyr Leu Cys Ser Ala Thr 
            500                 505                 510         


Arg Arg Lys Arg His Ser Glu His Ala Phe Asp His Ala Val Asp Ser 
        515                 520                 525             


Asp 
    


<210>  2329
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  2329

Met Ala Thr Ser Trp Gly Thr Val Phe Phe Met Leu Val Val Ser Cys 
1               5                   10                  15      


Val Cys Ser Ala Val Ser His Arg Asn Gln Gln Thr Trp Phe Glu Gly 
            20                  25                  30          


Ile Phe Leu Ser Ser Met Cys Pro Ile Asn Val Ser Ala Ser Thr Leu 
        35                  40                  45              


Tyr Gly Ile Met Phe Asp Ala Gly Ser Thr Gly Thr Arg Ile His Val 
    50                  55                  60                  


Tyr Thr Phe Val Gln Lys Met Pro Gly Gln Leu Pro Ile Leu Glu Gly 
65                  70                  75                  80  


Glu Val Phe Asp Ser Val Lys Pro Gly Leu Ser Ala Phe Val Asp Gln 
                85                  90                  95      


Pro Lys Gln Gly Ala Glu Thr Val Gln Gly Leu Leu Glu Val Ala Lys 
            100                 105                 110         


Asp Ser Ile Pro Arg Ser His Trp Lys Lys Thr Pro Val Val Leu Lys 
        115                 120                 125             


Ala Thr Ala Gly Leu Arg Leu Leu Pro Glu His Lys Ala Lys Ala Leu 
    130                 135                 140                 


Leu Phe Glu Val Lys Glu Ile Phe Arg Lys Ser Pro Phe Leu Val Pro 
145                 150                 155                 160 


Lys Gly Ser Val Ser Ile Met Asp Gly Ser Asp Glu Gly Ile Leu Ala 
                165                 170                 175     


Trp Val Thr Val Asn Phe Leu Thr Gly Gln Leu His Gly His Arg Gln 
            180                 185                 190         


Glu Thr Val Gly Thr Leu Asp Leu Gly Gly Ala Ser Thr Gln Ile Thr 
        195                 200                 205             


Phe Leu Pro Gln Phe Glu Lys Thr Leu Glu Gln Thr Pro Arg Gly Tyr 
    210                 215                 220                 


Leu Thr Ser Phe Glu Met Phe Asn Ser Thr Tyr Lys Leu Tyr Thr His 
225                 230                 235                 240 


Ser Tyr Leu Gly Phe Gly Leu Lys Ala Ala Arg Leu Ala Thr Leu Gly 
                245                 250                 255     


Ala Leu Glu Thr Glu Gly Thr Asp Gly His Thr Phe Arg Ser Ala Cys 
            260                 265                 270         


Leu Pro Arg Trp Leu Glu Ala Glu Trp Ile Phe Gly Gly Val Lys Tyr 
        275                 280                 285             


Gln Tyr Gly Gly Asn Gln Glu Gly Glu Val Gly Phe Glu Pro Cys Tyr 
    290                 295                 300                 


Ala Glu Val Leu Arg Val Val Arg Gly Lys Leu His Gln Pro Glu Glu 
305                 310                 315                 320 


Val Gln Arg Gly Ser Phe Tyr Ala Phe Ser Tyr Tyr Tyr Asp Arg Ala 
                325                 330                 335     


Val Asp Thr Asp Met Ile Asp Tyr Glu Lys Gly Gly Ile Leu Lys Val 
            340                 345                 350         


Glu Asp Phe Glu Arg Lys Ala Arg Glu Val Cys Asp Asn Leu Glu Asn 
        355                 360                 365             


Phe Thr Ser Gly Ser Pro Phe Leu Cys Met Asp Leu Ser Tyr Ile Thr 
    370                 375                 380                 


Ala Leu Leu Lys Asp Gly Phe Gly Phe Ala Asp Ser Thr Val Leu Gln 
385                 390                 395                 400 


Leu Thr Lys Lys Val Asn Asn Ile Glu Thr Gly Trp Ala Leu Gly Ala 
                405                 410                 415     


Thr Phe His Leu Leu Gln Ser Leu Gly Ile Ser His 
            420                 425             


<210>  2330
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  2330

Met Arg Leu Ala Val Leu Phe Ser Gly Ala Leu Leu Gly Leu Leu Ala 
1               5                   10                  15      


Ala Gln Gly Thr Gly Asn Asp Cys Pro His Lys Lys Ser Ala Thr Leu 
            20                  25                  30          


Leu Pro Ser Phe Thr Val Thr Pro Thr Val Thr Glu Ser Thr Gly Thr 
        35                  40                  45              


Thr Ser His Arg Thr Thr Lys Ser His Lys Thr Thr Thr His Arg Thr 
    50                  55                  60                  


Thr Thr Thr Gly Thr Thr Ser His Gly Pro Thr Thr Ala Thr His Asn 
65                  70                  75                  80  


Pro Thr Thr Thr Ser His Gly Asn Val Thr Val His Pro Thr Ser Asn 
                85                  90                  95      


Ser Thr Ala Thr Ser Gln Gly Pro Ser Thr Ala Thr His Ser Pro Ala 
            100                 105                 110         


Thr Thr Ser His Gly Asn Ala Thr Val His Pro Thr Ser Asn Ser Thr 
        115                 120                 125             


Ala Thr Ser Pro Gly Phe Thr Ser Ser Ala His Pro Glu Pro Pro Pro 
    130                 135                 140                 


Pro Ser Pro Ser Pro Ser Pro Thr Ser Lys Glu Thr Ile Gly Asp Tyr 
145                 150                 155                 160 


Thr Trp Thr Asn Gly Ser Gln Pro Cys Val His Leu Gln Ala Gln Ile 
                165                 170                 175     


Gln Ile Arg Val Met Tyr Thr Thr Gln Gly Gly Gly Glu Ala Trp Gly 
            180                 185                 190         


Ile Ser Val Leu Asn Pro Asn Lys Thr Lys Val Gln Gly Ser Cys Glu 
        195                 200                 205             


Gly Ala His Pro His Leu Leu Leu Ser Phe Pro Tyr Gly His Leu Ser 
    210                 215                 220                 


Phe Gly Phe Met Gln Asp Leu Gln Gln Lys Val Val Tyr Leu Ser Tyr 
225                 230                 235                 240 


Met Ala Val Glu Tyr Asn Val Ser Phe Pro His Ala Ala Gln Trp Thr 
                245                 250                 255     


Phe Ser Ala Gln Asn Ala Ser Leu Arg Asp Leu Gln Ala Pro Leu Gly 
            260                 265                 270         


Gln Ser Phe Ser Cys Ser Asn Ser Ser Ile Ile Leu Ser Pro Ala Val 
        275                 280                 285             


His Leu Asp Leu Leu Ser Leu Arg Leu Gln Ala Ala Gln Leu Pro His 
    290                 295                 300                 


Thr Gly Val Phe Gly Gln Ser Phe Ser Cys Pro Ser Asp Arg Ser Ile 
305                 310                 315                 320 


Leu Leu Pro Leu Ile Ile Gly Leu Ile Leu Leu Gly Leu Leu Ala Leu 
                325                 330                 335     


Val Leu Ile Ala Phe Cys Ile Ile Arg Arg Arg Pro Ser Ala Tyr Gln 
            340                 345                 350         


Ala Leu 
        


<210>  2331
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  2331

Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly 
1               5                   10                  15      


Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
            20                  25                  30          


Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu 
        35                  40                  45              


Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His 
    50                  55                  60                  


Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala 
65                  70                  75                  80  


Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu 
                85                  90                  95      


Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu 
            100                 105                 110         


Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 
        115                 120                 125             


Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg 
    130                 135                 140                 


Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro 
145                 150                 155                 160 


Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu 
                165                 170                 175     


Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg 
            180                 185                 190         


Pro 
    


<210>  2332
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  2332

Met Leu Glu Leu Arg His Arg Gly Ser Cys Pro Gly Pro Arg Glu Ala 
1               5                   10                  15      


Val Ser Pro Pro His Arg Glu Gly Glu Ala Ala Gly Gly Asp His Glu 
            20                  25                  30          


Thr Glu Ser Thr Ser Asp Lys Glu Thr Asp Ile Asp Asp Arg Tyr Gly 
        35                  40                  45              


Asp Leu Asp Ser Arg Thr Asp Ser Asp Ile Pro Glu Ile Pro Pro Ser 
    50                  55                  60                  


Ser Asp Arg Thr Pro Glu Ile Leu Lys Lys Ala Leu Ser Gly Leu Ser 
65                  70                  75                  80  


Ser Arg Trp Lys Asn Trp Trp Ile Arg Gly Ile Leu Thr Leu Thr Met 
                85                  90                  95      


Ile Ser Leu Phe Phe Leu Ile Ile Tyr Met Gly Ser Phe Met Leu Met 
            100                 105                 110         


Leu Leu Val Leu Gly Ile Gln Val Lys Cys Phe His Glu Ile Ile Thr 
        115                 120                 125             


Ile Gly Tyr Arg Val Tyr His Ser Tyr Asp Leu Pro Trp Phe Arg Thr 
    130                 135                 140                 


Leu Ser Trp Tyr Phe Leu Leu Cys Val Asn Tyr Phe Phe Tyr Gly Glu 
145                 150                 155                 160 


Thr Val Ala Asp Tyr Phe Ala Thr Phe Val Gln Arg Glu Glu Gln Leu 
                165                 170                 175     


Gln Phe Leu Ile Arg Tyr His Arg Phe Ile Ser Phe Ala Leu Tyr Leu 
            180                 185                 190         


Ala Gly Phe Cys Met Phe Val Leu Ser Leu Val Lys Lys His Tyr Arg 
        195                 200                 205             


Leu Gln Phe Tyr Met Phe Ala Trp Thr His Val Thr Leu Leu Ile Thr 
    210                 215                 220                 


Val Thr Gln Ser His Leu Val Ile Gln Asn Leu Phe Glu Gly Met Ile 
225                 230                 235                 240 


Trp Phe Leu Val Pro Ile Ser Ser Val Ile Cys Asn Asp Ile Thr Ala 
                245                 250                 255     


Tyr Leu Phe Gly Phe Phe Phe Gly Arg Thr Pro Leu Ile Lys Leu Ser 
            260                 265                 270         


Pro Lys Lys Thr Trp Glu Gly Phe Ile Gly Gly Phe Phe Ser Thr Val 
        275                 280                 285             


Val Phe Gly Phe Ile Ala Ala Tyr Val Leu Ser Lys Tyr Gln Tyr Phe 
    290                 295                 300                 


Val Cys Pro Val Glu Tyr Arg Ser Asp Val Asn Ser Phe Val Thr Glu 
305                 310                 315                 320 


Cys Glu Pro Ser Glu Leu Phe Gln Leu Gln Thr Tyr Ser Leu Pro Pro 
                325                 330                 335     


Phe Leu Lys Ala Val Leu Arg Gln Glu Arg Val Ser Leu Tyr Pro Phe 
            340                 345                 350         


Gln Ile His Ser Ile Ala Leu Ser Thr Phe Ala Ser Leu Ile Gly Pro 
        355                 360                 365             


Phe Gly Gly Phe Phe Ala Ser Gly Phe Lys Arg Ala Phe Lys Ile Lys 
    370                 375                 380                 


Asp Phe Ala Asn Thr Ile Pro Gly His Gly Gly Ile Met Asp Arg Phe 
385                 390                 395                 400 


Asp Cys Gln Tyr Leu Met Ala Thr Phe Val His Val Tyr Ile Thr Ser 
                405                 410                 415     


Phe Ile Arg Gly Pro Asn Pro Ser Lys Val Leu Gln Gln Leu Leu Val 
            420                 425                 430         


Leu Gln Pro Glu Gln Gln Leu Asn Ile Tyr Lys Thr Leu Lys Thr His 
        435                 440                 445             


Leu Ile Glu Lys Gly Ile Leu Gln Pro Thr Leu Lys Val 
    450                 455                 460     


<210>  2333
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  2333

Met Gly Ser Ser Arg Ala Pro Trp Met Gly Arg Val Gly Gly His Gly 
1               5                   10                  15      


Met Met Ala Leu Leu Leu Ala Gly Leu Leu Leu Pro Gly Thr Leu Ala 
            20                  25                  30          


Lys Ser Ile Gly Thr Phe Ser Asp Pro Cys Lys Asp Pro Thr Arg Ile 
        35                  40                  45              


Thr Ser Pro Asn Asp Pro Cys Leu Thr Gly Lys Gly Asp Ser Ser Gly 
    50                  55                  60                  


Phe Ser Ser Tyr Ser Gly Ser Ser Ser Ser Gly Ser Ser Ile Ser Ser 
65                  70                  75                  80  


Ala Arg Ser Ser Gly Gly Gly Ser Ser Gly Ser Ser Ser Gly Ser Ser 
                85                  90                  95      


Ile Ala Gln Gly Gly Ser Ala Gly Ser Phe Lys Pro Gly Thr Gly Tyr 
            100                 105                 110         


Ser Gln Val Ser Tyr Ser Ser Gly Ser Gly Ser Ser Leu Gln Gly Ala 
        115                 120                 125             


Ser Gly Ser Ser Gln Leu Gly Ser Ser Ser Ser His Ser Gly Ser Ser 
    130                 135                 140                 


Gly Ser His Ser Gly Ser Ser Ser Ser His Ser Ser Ser Ser Ser Ser 
145                 150                 155                 160 


Phe Gln Phe Ser Ser Ser Ser Phe Gln Val Gly Asn Gly Ser Ala Leu 
                165                 170                 175     


Pro Thr Asn Asp Asn Ser Tyr Arg Gly Ile Leu Asn Pro Ser Gln Pro 
            180                 185                 190         


Gly Gln Ser Ser Ser Ser Ser Gln Thr Phe Gly Val Ser Ser Ser Gly 
        195                 200                 205             


Gln Ser Val Ser Ser Asn Gln Arg Pro Cys Ser Ser Asp Ile Pro Asp 
    210                 215                 220                 


Ser Pro Cys Ser Gly Gly Pro Ile Val Ser His Ser Gly Pro Tyr Ile 
225                 230                 235                 240 


Pro Ser Ser His Ser Val Ser Gly Gly Gln Arg Pro Val Val Val Val 
                245                 250                 255     


Val Asp Gln His Gly Ser Gly Ala Pro Gly Val Val Gln Gly Pro Pro 
            260                 265                 270         


Cys Ser Asn Gly Gly Leu Pro Gly Lys Pro Cys Pro Pro Ile Thr Ser 
        275                 280                 285             


Val Asp Lys Ser Tyr Gly Gly Tyr Glu Val Val Gly Gly Ser Ser Asp 
    290                 295                 300                 


Ser Tyr Leu Val Pro Gly Met Thr Tyr Ser Lys Gly Lys Ile Tyr Pro 
305                 310                 315                 320 


Val Gly Tyr Phe Thr Lys Glu Asn Pro Val Lys Gly Ser Pro Gly Val 
                325                 330                 335     


Pro Ser Phe Ala Ala Gly Pro Pro Ile Ser Glu Gly Lys Tyr Phe Ser 
            340                 345                 350         


Ser Asn Pro Ile Ile Pro Ser Gln Ser Ala Ala Ser Ser Ala Ile Ala 
        355                 360                 365             


Phe Gln Pro Val Gly Thr Gly Gly Val Gln Leu Cys Gly Gly Gly Ser 
    370                 375                 380                 


Thr Gly Ser Lys Gly Pro Cys Ser Pro Ser Ser Ser Arg Val Pro Ser 
385                 390                 395                 400 


Ser Ser Ser Ile Ser Ser Ser Ser Gly Leu Pro Tyr His Pro Cys Gly 
                405                 410                 415     


Ser Ala Ser Gln Ser Pro Cys Ser Pro Pro Gly Thr Gly Ser Phe Ser 
            420                 425                 430         


Ser Ser Ser Ser Ser Gln Ser Ser Gly Lys Ile Ile Leu Gln Pro Cys 
        435                 440                 445             


Gly Ser Lys Ser Ser Ser Ser Gly His Pro Cys Met Ser Val Ser Ser 
    450                 455                 460                 


Leu Thr Leu Thr Gly Gly Pro Asp Gly Ser Pro His Pro Asp Pro Ser 
465                 470                 475                 480 


Ala Gly Ala Lys Pro Cys Gly Ser Ser Ser Ala Gly Lys Ile Pro Cys 
                485                 490                 495     


Arg Ser Ile Arg Asp Ile Leu Ala Gln Val Lys Pro Leu Gly Pro Gln 
            500                 505                 510         


Leu Ala Asp Pro Glu Val Phe Leu Pro Gln Gly Glu Leu Leu Asn Ser 
        515                 520                 525             


Pro 
    


<210>  2334
<211>  869
<212>  PRT
<213>  Homo sapiens

<400>  2334

Met Ala Gly Cys Arg Gly Ser Leu Cys Cys Cys Cys Arg Trp Cys Cys 
1               5                   10                  15      


Cys Cys Gly Glu Arg Glu Thr Arg Thr Pro Glu Glu Leu Thr Ile Leu 
            20                  25                  30          


Gly Glu Thr Gln Glu Glu Glu Asp Glu Ile Leu Pro Arg Lys Asp Tyr 
        35                  40                  45              


Glu Ser Leu Asp Tyr Asp Arg Cys Ile Asn Asp Pro Tyr Leu Glu Val 
    50                  55                  60                  


Leu Glu Thr Met Asp Asn Lys Lys Gly Arg Arg Tyr Glu Ala Val Lys 
65                  70                  75                  80  


Trp Met Val Val Phe Ala Ile Gly Val Cys Thr Gly Leu Val Gly Leu 
                85                  90                  95      


Phe Val Asp Phe Phe Val Arg Leu Phe Thr Gln Leu Lys Phe Gly Val 
            100                 105                 110         


Val Gln Thr Ser Val Glu Glu Cys Ser Gln Lys Gly Cys Leu Ala Leu 
        115                 120                 125             


Ser Leu Leu Glu Leu Leu Gly Phe Asn Leu Thr Phe Val Phe Leu Ala 
    130                 135                 140                 


Ser Leu Leu Val Leu Ile Glu Pro Val Ala Ala Gly Ser Gly Ile Pro 
145                 150                 155                 160 


Glu Val Lys Cys Tyr Leu Asn Gly Val Lys Val Pro Gly Ile Val Arg 
                165                 170                 175     


Leu Arg Thr Leu Leu Cys Lys Val Leu Gly Val Leu Phe Ser Val Ala 
            180                 185                 190         


Gly Gly Leu Phe Val Gly Lys Glu Gly Pro Met Ile His Ser Gly Ser 
        195                 200                 205             


Val Val Gly Ala Gly Leu Pro Gln Phe Gln Ser Ile Ser Leu Arg Lys 
    210                 215                 220                 


Ile Gln Phe Asn Phe Pro Tyr Phe Arg Ser Asp Arg Asp Lys Arg Asp 
225                 230                 235                 240 


Phe Val Ser Ala Gly Ala Ala Ala Gly Val Ala Ala Ala Phe Gly Ala 
                245                 250                 255     


Pro Ile Gly Gly Thr Leu Phe Ser Leu Glu Glu Gly Ser Ser Phe Trp 
            260                 265                 270         


Asn Gln Gly Leu Thr Trp Lys Val Leu Phe Cys Ser Met Ser Ala Thr 
        275                 280                 285             


Phe Thr Leu Asn Phe Phe Arg Ser Gly Ile Gln Phe Gly Ser Trp Gly 
    290                 295                 300                 


Ser Phe Gln Leu Pro Gly Leu Leu Asn Phe Gly Glu Phe Lys Cys Ser 
305                 310                 315                 320 


Asp Ser Asp Lys Lys Cys His Leu Trp Thr Ala Met Asp Leu Gly Phe 
                325                 330                 335     


Phe Val Val Met Gly Val Ile Gly Gly Leu Leu Gly Ala Thr Phe Asn 
            340                 345                 350         


Cys Leu Asn Lys Arg Leu Ala Lys Tyr Arg Met Arg Asn Val His Pro 
        355                 360                 365             


Lys Pro Lys Leu Val Arg Val Leu Glu Ser Leu Leu Val Ser Leu Val 
    370                 375                 380                 


Thr Thr Val Val Val Phe Val Ala Ser Met Val Leu Gly Glu Cys Arg 
385                 390                 395                 400 


Gln Met Ser Ser Ser Ser Gln Ile Gly Asn Asp Ser Phe Gln Leu Gln 
                405                 410                 415     


Val Thr Glu Asp Val Asn Ser Ser Ile Lys Thr Phe Phe Cys Pro Asn 
            420                 425                 430         


Asp Thr Tyr Asn Asp Met Ala Thr Leu Phe Phe Asn Pro Gln Glu Ser 
        435                 440                 445             


Ala Ile Leu Gln Leu Phe His Gln Asp Gly Thr Phe Ser Pro Val Thr 
    450                 455                 460                 


Leu Ala Leu Phe Phe Val Leu Tyr Phe Leu Leu Ala Cys Trp Thr Tyr 
465                 470                 475                 480 


Gly Ile Ser Val Pro Ser Gly Leu Phe Val Pro Ser Leu Leu Cys Gly 
                485                 490                 495     


Ala Ala Phe Gly Arg Leu Val Ala Asn Val Leu Lys Ser Tyr Ile Gly 
            500                 505                 510         


Leu Gly His Ile Tyr Ser Gly Thr Phe Ala Leu Ile Gly Ala Ala Ala 
        515                 520                 525             


Phe Leu Gly Gly Val Val Arg Met Thr Ile Ser Leu Thr Val Ile Leu 
    530                 535                 540                 


Ile Glu Ser Thr Asn Glu Ile Thr Tyr Gly Leu Pro Ile Met Val Thr 
545                 550                 555                 560 


Leu Met Val Ala Lys Trp Thr Gly Asp Phe Phe Asn Lys Gly Ile Tyr 
                565                 570                 575     


Asp Ile His Val Gly Leu Arg Gly Val Pro Leu Leu Glu Trp Glu Thr 
            580                 585                 590         


Glu Val Glu Met Asp Lys Leu Arg Ala Ser Asp Ile Met Glu Pro Asn 
        595                 600                 605             


Leu Thr Tyr Val Tyr Pro His Thr Arg Ile Gln Ser Leu Val Ser Ile 
    610                 615                 620                 


Leu Arg Thr Thr Val His His Ala Phe Pro Val Val Thr Glu Asn Arg 
625                 630                 635                 640 


Gly Asn Glu Lys Glu Phe Met Lys Gly Asn Gln Leu Ile Ser Asn Asn 
                645                 650                 655     


Ile Lys Phe Lys Lys Ser Ser Ile Leu Thr Arg Ala Gly Glu Gln Arg 
            660                 665                 670         


Lys Arg Ser Gln Ser Met Lys Ser Tyr Pro Ser Ser Glu Leu Arg Asn 
        675                 680                 685             


Met Cys Asp Glu His Ile Ala Ser Glu Glu Pro Ala Glu Lys Glu Asp 
    690                 695                 700                 


Leu Leu Gln Gln Met Leu Glu Arg Arg Tyr Thr Pro Tyr Pro Asn Leu 
705                 710                 715                 720 


Tyr Pro Asp Gln Ser Pro Ser Glu Asp Trp Thr Met Glu Glu Arg Phe 
                725                 730                 735     


Arg Pro Leu Thr Phe His Gly Leu Ile Leu Arg Ser Gln Leu Val Thr 
            740                 745                 750         


Leu Leu Val Arg Gly Val Cys Tyr Ser Glu Ser Gln Ser Ser Ala Ser 
        755                 760                 765             


Gln Pro Arg Leu Ser Tyr Ala Glu Met Ala Glu Asp Tyr Pro Arg Tyr 
    770                 775                 780                 


Pro Asp Ile His Asp Leu Asp Leu Thr Leu Leu Asn Pro Arg Met Ile 
785                 790                 795                 800 


Val Asp Val Thr Pro Tyr Met Asn Pro Ser Pro Phe Thr Val Ser Pro 
                805                 810                 815     


Asn Thr His Val Ser Gln Val Phe Asn Leu Phe Arg Thr Met Gly Leu 
            820                 825                 830         


Arg His Leu Pro Val Val Asn Ala Val Gly Glu Ile Val Gly Ile Ile 
        835                 840                 845             


Thr Arg His Asn Leu Thr Tyr Glu Phe Leu Gln Ala Arg Leu Arg Gln 
    850                 855                 860                 


His Tyr Gln Thr Ile 
865                 


<210>  2335
<211>  805
<212>  PRT
<213>  Homo sapiens

<400>  2335

Met Ala Asn Val Ser Lys Lys Val Ser Trp Ser Gly Arg Asp Arg Asp 
1               5                   10                  15      


Asp Glu Glu Ala Ala Pro Leu Leu Arg Arg Thr Ala Arg Pro Gly Gly 
            20                  25                  30          


Gly Thr Pro Leu Leu Asn Gly Ala Gly Pro Gly Ala Ala Arg Gln Ser 
        35                  40                  45              


Pro Arg Ser Ala Leu Phe Arg Val Gly His Met Ser Ser Val Glu Leu 
    50                  55                  60                  


Asp Asp Glu Leu Leu Asp Pro Asp Met Asp Pro Pro His Pro Phe Pro 
65                  70                  75                  80  


Lys Glu Ile Pro His Asn Glu Lys Leu Leu Ser Leu Lys Tyr Glu Ser 
                85                  90                  95      


Leu Asp Tyr Asp Asn Ser Glu Asn Gln Leu Phe Leu Glu Glu Glu Arg 
            100                 105                 110         


Arg Ile Asn His Thr Ala Phe Arg Thr Val Glu Ile Lys Arg Trp Val 
        115                 120                 125             


Ile Cys Ala Leu Ile Gly Ile Leu Thr Gly Leu Val Ala Cys Phe Ile 
    130                 135                 140                 


Asp Ile Val Val Glu Asn Leu Ala Gly Leu Lys Tyr Arg Val Ile Lys 
145                 150                 155                 160 


Gly Asn Ile Asp Lys Phe Thr Glu Lys Gly Gly Leu Ser Phe Ser Leu 
                165                 170                 175     


Leu Leu Trp Ala Thr Leu Asn Ala Ala Phe Val Leu Val Gly Ser Val 
            180                 185                 190         


Ile Val Ala Phe Ile Glu Pro Val Ala Ala Gly Ser Gly Ile Pro Gln 
        195                 200                 205             


Ile Lys Cys Phe Leu Asn Gly Val Lys Ile Pro His Val Val Arg Leu 
    210                 215                 220                 


Lys Thr Leu Val Ile Lys Val Ser Gly Val Ile Leu Ser Val Val Gly 
225                 230                 235                 240 


Gly Leu Ala Val Gly Lys Glu Gly Pro Met Ile His Ser Gly Ser Val 
                245                 250                 255     


Ile Ala Ala Gly Ile Ser Gln Gly Arg Ser Thr Ser Leu Lys Arg Asp 
            260                 265                 270         


Phe Lys Ile Phe Glu Tyr Phe Arg Arg Asp Thr Glu Lys Arg Asp Phe 
        275                 280                 285             


Val Ser Ala Gly Ala Ala Ala Gly Val Ser Ala Ala Phe Gly Ala Pro 
    290                 295                 300                 


Val Gly Gly Val Leu Phe Ser Leu Glu Glu Gly Ala Ser Phe Trp Asn 
305                 310                 315                 320 


Gln Phe Leu Thr Trp Arg Ile Phe Phe Ala Ser Met Ile Ser Thr Phe 
                325                 330                 335     


Thr Leu Asn Phe Val Leu Ser Ile Tyr His Gly Asn Met Trp Asp Leu 
            340                 345                 350         


Ser Ser Pro Gly Leu Ile Asn Phe Gly Arg Phe Asp Ser Glu Lys Met 
        355                 360                 365             


Ala Tyr Thr Ile His Glu Ile Pro Val Phe Ile Ala Met Gly Val Val 
    370                 375                 380                 


Gly Gly Val Leu Gly Ala Val Phe Asn Ala Leu Asn Tyr Trp Leu Thr 
385                 390                 395                 400 


Met Phe Arg Ile Arg Tyr Ile His Arg Pro Cys Leu Gln Val Ile Glu 
                405                 410                 415     


Ala Val Leu Val Ala Ala Val Thr Ala Thr Val Ala Phe Val Leu Ile 
            420                 425                 430         


Tyr Ser Ser Arg Asp Cys Gln Pro Leu Gln Gly Gly Ser Met Ser Tyr 
        435                 440                 445             


Pro Leu Gln Leu Phe Cys Ala Asp Gly Glu Tyr Asn Ser Met Ala Ala 
    450                 455                 460                 


Ala Phe Phe Asn Thr Pro Glu Lys Ser Val Val Ser Leu Phe His Asp 
465                 470                 475                 480 


Pro Pro Gly Ser Tyr Asn Pro Leu Thr Leu Gly Leu Phe Thr Leu Val 
                485                 490                 495     


Tyr Phe Phe Leu Ala Cys Trp Thr Tyr Gly Leu Thr Val Ser Ala Gly 
            500                 505                 510         


Val Phe Ile Pro Ser Leu Leu Ile Gly Ala Ala Trp Gly Arg Leu Phe 
        515                 520                 525             


Gly Ile Ser Leu Ser Tyr Leu Thr Gly Ala Ala Ile Trp Ala Asp Pro 
    530                 535                 540                 


Gly Lys Tyr Ala Leu Met Gly Ala Ala Ala Gln Leu Gly Gly Ile Val 
545                 550                 555                 560 


Arg Met Thr Leu Ser Leu Thr Val Ile Met Met Glu Ala Thr Ser Asn 
                565                 570                 575     


Val Thr Tyr Gly Phe Pro Ile Met Leu Val Leu Met Thr Ala Lys Ile 
            580                 585                 590         


Val Gly Asp Val Phe Ile Glu Gly Leu Tyr Asp Met His Ile Gln Leu 
        595                 600                 605             


Gln Ser Val Pro Phe Leu His Trp Glu Ala Pro Val Thr Ser His Ser 
    610                 615                 620                 


Leu Thr Ala Arg Glu Val Met Ser Thr Pro Val Thr Cys Leu Arg Arg 
625                 630                 635                 640 


Arg Glu Lys Val Gly Val Ile Val Asp Val Leu Ser Asp Thr Ala Ser 
                645                 650                 655     


Asn His Asn Gly Phe Pro Val Val Glu His Ala Asp Asp Thr Gln Pro 
            660                 665                 670         


Ala Arg Leu Gln Gly Leu Ile Leu Arg Ser Gln Leu Ile Val Leu Leu 
        675                 680                 685             


Lys His Lys Val Phe Val Glu Arg Ser Asn Leu Gly Leu Val Gln Arg 
    690                 695                 700                 


Arg Leu Arg Leu Lys Asp Phe Arg Asp Ala Tyr Pro Arg Phe Pro Pro 
705                 710                 715                 720 


Ile Gln Ser Ile His Val Ser Gln Asp Glu Arg Glu Cys Thr Met Asp 
                725                 730                 735     


Leu Ser Glu Phe Met Asn Pro Ser Pro Tyr Thr Val Pro Gln Glu Ala 
            740                 745                 750         


Ser Leu Pro Arg Val Phe Lys Leu Phe Arg Ala Leu Gly Leu Arg His 
        755                 760                 765             


Leu Val Val Val Asp Asn Arg Asn Gln Val Val Gly Leu Val Thr Arg 
    770                 775                 780                 


Lys Asp Leu Ala Arg Tyr Arg Leu Gly Lys Arg Gly Leu Glu Glu Leu 
785                 790                 795                 800 


Ser Leu Ala Gln Thr 
                805 


<210>  2336
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  2336

Met Ala Ala Ala Gln Glu Ala Asp Gly Ala Arg Ser Ala Val Val Ala 
1               5                   10                  15      


Ala Gly Gly Gly Ser Ser Gly Gln Val Thr Ser Asn Gly Ser Ile Gly 
            20                  25                  30          


Arg Asp Pro Pro Ala Glu Thr Gln Pro Gln Asn Pro Pro Ala Gln Pro 
        35                  40                  45              


Ala Pro Asn Ala Trp Gln Val Ile Lys Gly Val Leu Phe Arg Ile Phe 
    50                  55                  60                  


Ile Ile Trp Ala Ile Ser Ser Trp Phe Arg Arg Gly Pro Ala Pro Gln 
65                  70                  75                  80  


Asp Gln Ala Gly Pro Gly Gly Ala Pro Arg Val Ala Ser Arg Asn Leu 
                85                  90                  95      


Phe Pro Lys Asp Thr Leu Met Asn Leu His Val Tyr Ile Ser Glu His 
            100                 105                 110         


Glu His Phe Thr Asp Phe Asn Ala Thr Ser Ala Leu Phe Trp Glu Gln 
        115                 120                 125             


His Asp Leu Val Tyr Gly Asp Trp Thr Ser Gly Glu Asn Ser Asp Gly 
    130                 135                 140                 


Cys Tyr Glu His Phe Ala Glu Leu Asp Ile Pro Gln Ser Val Gln Gln 
145                 150                 155                 160 


Asn Gly Ser Ile Tyr Ile His Val Tyr Phe Thr Lys Ser Gly Phe His 
                165                 170                 175     


Pro Asp Pro Arg Gln Lys Ala Leu Tyr Arg Arg Leu Ala Thr Val His 
            180                 185                 190         


Met Ser Arg Met Ile Asn Lys Tyr Lys Arg Arg Arg Phe Gln Lys Thr 
        195                 200                 205             


Lys Asn Leu Leu Thr Gly Glu Thr Glu Ala Asp Pro Glu Met Ile Lys 
    210                 215                 220                 


Arg Ala Glu Asp Tyr Gly Pro Val Glu Val Ile Ser His Trp His Pro 
225                 230                 235                 240 


Asn Ile Thr Ile Asn Ile Val Asp Asp His Thr Pro Trp Val Lys Gly 
                245                 250                 255     


Ser Val Pro Pro Pro Leu Asp Gln Tyr Val Lys Phe Asp Ala Val Ser 
            260                 265                 270         


Gly Asp Tyr Tyr Pro Ile Ile Tyr Phe Asn Asp Tyr Trp Asn Leu Gln 
        275                 280                 285             


Lys Asp Tyr Tyr Pro Ile Asn Glu Ser Leu Ala Ser Leu Pro Leu Arg 
    290                 295                 300                 


Val Ser Phe Cys Pro Leu Ser Leu Trp Arg Trp Gln Leu Tyr Ala Ala 
305                 310                 315                 320 


Gln Ser Thr Lys Ser Pro Trp Asn Phe Leu Gly Asp Glu Leu Tyr Glu 
                325                 330                 335     


Gln Ser Asp Glu Glu Gln Asp Ser Val Lys Val Ala Leu Leu Glu Thr 
            340                 345                 350         


Asn Pro Tyr Leu Leu Ala Leu Thr Ile Ile Val Ser Ile Val His Ser 
        355                 360                 365             


Val Phe Glu Phe Leu Ala Phe Lys Asn Asp Ile Gln Phe Trp Asn Ser 
    370                 375                 380                 


Arg Gln Ser Leu Glu Gly Leu Ser Val Arg Ser Val Phe Phe Gly Val 
385                 390                 395                 400 


Phe Gln Ser Phe Val Val Leu Leu Tyr Ile Leu Asp Asn Glu Thr Asn 
                405                 410                 415     


Phe Val Val Gln Val Ser Val Phe Ile Gly Val Leu Ile Asp Leu Trp 
            420                 425                 430         


Lys Ile Thr Lys Val Met Asp Val Arg Leu Asp Arg Glu His Arg Val 
        435                 440                 445             


Ala Gly Ile Phe Pro Arg Leu Ser Phe Lys Asp Lys Ser Thr Tyr Ile 
    450                 455                 460                 


Glu Ser Ser Thr Lys Val Tyr Asp Asp Met Ala Phe Arg Tyr Leu Ser 
465                 470                 475                 480 


Trp Ile Leu Phe Pro Leu Leu Gly Cys Tyr Ala Val Tyr Ser Leu Leu 
                485                 490                 495     


Tyr Leu Glu His Lys Gly Trp Tyr Ser Trp Val Leu Ser Met Leu Tyr 
            500                 505                 510         


Gly Phe Leu Leu Thr Phe Gly Phe Ile Thr Met Thr Pro Gln Leu Phe 
        515                 520                 525             


Ile Asn Tyr Lys Leu Lys Ser Val Ala His Leu Pro Trp Arg Met Leu 
    530                 535                 540                 


Thr Tyr Lys Ala Leu Asn Thr Phe Ile Asp Asp Leu Phe Ala Phe Val 
545                 550                 555                 560 


Ile Lys Met Pro Val Met Tyr Arg Ile Gly Cys Leu Arg Asp Asp Val 
                565                 570                 575     


Val Phe Phe Ile Tyr Leu Tyr Gln Arg Trp Ile Tyr Arg Val Asp Pro 
            580                 585                 590         


Thr Arg Val Asn Glu Phe Gly Met Ser Gly Glu Asp Pro Thr Ala Ala 
        595                 600                 605             


Ala Pro Val Ala Glu Val Pro Thr Ala Ala Gly Ala Leu Thr Pro Thr 
    610                 615                 620                 


Pro Ala Pro Thr Thr Thr Thr Ala Thr Arg Glu Glu Ala Ser Thr Ser 
625                 630                 635                 640 


Leu Pro Thr Lys Pro Thr Gln Gly Ala Ser Ser Ala Ser Glu Pro Gln 
                645                 650                 655     


Glu Ala Pro Pro Lys Pro Ala Glu Asp Lys Lys Lys Asp 
            660                 665                 


<210>  2337
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  2337

Met Glu Thr Pro Asn Thr Thr Glu Asp Tyr Asp Thr Thr Thr Glu Phe 
1               5                   10                  15      


Asp Tyr Gly Asp Ala Thr Pro Cys Gln Lys Val Asn Glu Arg Ala Phe 
            20                  25                  30          


Gly Ala Gln Leu Leu Pro Pro Leu Tyr Ser Leu Val Phe Val Ile Gly 
        35                  40                  45              


Leu Val Gly Asn Ile Leu Val Val Leu Val Leu Val Gln Tyr Lys Arg 
    50                  55                  60                  


Leu Lys Asn Met Thr Ser Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp 
65                  70                  75                  80  


Leu Leu Phe Leu Phe Thr Leu Pro Phe Trp Ile Asp Tyr Lys Leu Lys 
                85                  90                  95      


Asp Asp Trp Val Phe Gly Asp Ala Met Cys Lys Ile Leu Ser Gly Phe 
            100                 105                 110         


Tyr Tyr Thr Gly Leu Tyr Ser Glu Ile Phe Phe Ile Ile Leu Leu Thr 
        115                 120                 125             


Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe Ala Leu Arg Ala 
    130                 135                 140                 


Arg Thr Val Thr Phe Gly Val Ile Thr Ser Ile Ile Ile Trp Ala Leu 
145                 150                 155                 160 


Ala Ile Leu Ala Ser Met Pro Gly Leu Tyr Phe Ser Lys Thr Gln Trp 
                165                 170                 175     


Glu Phe Thr His His Thr Cys Ser Leu His Phe Pro His Glu Ser Leu 
            180                 185                 190         


Arg Glu Trp Lys Leu Phe Gln Ala Leu Lys Leu Asn Leu Phe Gly Leu 
        195                 200                 205             


Val Leu Pro Leu Leu Val Met Ile Ile Cys Tyr Thr Gly Ile Ile Lys 
    210                 215                 220                 


Ile Leu Leu Arg Arg Pro Asn Glu Lys Lys Ser Lys Ala Val Arg Leu 
225                 230                 235                 240 


Ile Phe Val Ile Met Ile Ile Phe Phe Leu Phe Trp Thr Pro Tyr Asn 
                245                 250                 255     


Leu Thr Ile Leu Ile Ser Val Phe Gln Asp Phe Leu Phe Thr His Glu 
            260                 265                 270         


Cys Glu Gln Ser Arg His Leu Asp Leu Ala Val Gln Val Thr Glu Val 
        275                 280                 285             


Ile Ala Tyr Thr His Cys Cys Val Asn Pro Val Ile Tyr Ala Phe Val 
    290                 295                 300                 


Gly Glu Arg Phe Arg Lys Tyr Leu Arg Gln Leu Phe His Arg Arg Val 
305                 310                 315                 320 


Ala Val His Leu Val Lys Trp Leu Pro Phe Leu Ser Val Asp Arg Leu 
                325                 330                 335     


Glu Arg Val Ser Ser Thr Ser Pro Ser Thr Gly Glu His Glu Leu Ser 
            340                 345                 350         


Ala Gly Phe 
        355 


<210>  2338
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  2338

Met Ala Ala Thr Ala Ser Pro Gln Pro Leu Ala Thr Glu Asp Ala Asp 
1               5                   10                  15      


Ser Glu Asn Ser Ser Phe Tyr Tyr Tyr Asp Tyr Leu Asp Glu Val Ala 
            20                  25                  30          


Phe Met Leu Cys Arg Lys Asp Ala Val Val Ser Phe Gly Lys Val Phe 
        35                  40                  45              


Leu Pro Val Phe Tyr Ser Leu Ile Phe Val Leu Gly Leu Ser Gly Asn 
    50                  55                  60                  


Leu Leu Leu Leu Met Val Leu Leu Arg Tyr Val Pro Arg Arg Arg Met 
65                  70                  75                  80  


Val Glu Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asn Leu Leu Phe Leu 
                85                  90                  95      


Val Thr Leu Pro Phe Trp Gly Ile Ser Val Ala Trp His Trp Val Phe 
            100                 105                 110         


Gly Ser Phe Leu Cys Lys Met Val Ser Thr Leu Tyr Thr Ile Asn Phe 
        115                 120                 125             


Tyr Ser Gly Ile Phe Phe Ile Ser Cys Met Ser Leu Asp Lys Tyr Leu 
    130                 135                 140                 


Glu Ile Val His Ala Gln Pro Tyr His Arg Leu Arg Thr Arg Ala Lys 
145                 150                 155                 160 


Ser Leu Leu Leu Ala Thr Ile Val Trp Ala Val Ser Leu Ala Val Ser 
                165                 170                 175     


Ile Pro Asp Met Val Phe Val Gln Thr His Glu Asn Pro Lys Gly Val 
            180                 185                 190         


Trp Asn Cys His Ala Asp Phe Gly Gly His Gly Thr Ile Trp Lys Leu 
        195                 200                 205             


Phe Leu Arg Phe Gln Gln Asn Leu Leu Gly Phe Leu Leu Pro Leu Leu 
    210                 215                 220                 


Ala Met Ile Phe Phe Tyr Ser Arg Ile Gly Cys Val Leu Val Arg Leu 
225                 230                 235                 240 


Arg Pro Ala Gly Gln Gly Arg Ala Leu Lys Ile Ala Ala Ala Leu Val 
                245                 250                 255     


Val Ala Phe Phe Val Leu Trp Phe Pro Tyr Asn Leu Thr Leu Phe Leu 
            260                 265                 270         


His Thr Leu Leu Asp Leu Gln Val Phe Gly Asn Cys Glu Val Ser Gln 
        275                 280                 285             


His Leu Asp Tyr Ala Leu Gln Val Thr Glu Ser Ile Ala Phe Leu His 
    290                 295                 300                 


Cys Cys Phe Ser Pro Ile Leu Tyr Ala Phe Ser Ser His Arg Phe Arg 
305                 310                 315                 320 


Gln Tyr Leu Lys Ala Phe Leu Ala Ala Val Leu Gly Trp His Leu Ala 
                325                 330                 335     


Pro Gly Thr Ala Gln Ala Ser Leu Ser Ser Cys Ser Glu Ser Ser Ile 
            340                 345                 350         


Leu Thr Ala Gln Glu Glu Met Thr Gly Met Asn Asp Leu Gly Glu Arg 
        355                 360                 365             


Gln Ser Glu Asn Tyr Pro Asn Lys Glu Asp Val Gly Asn Lys Ser Ala 
    370                 375                 380                 


<210>  2339
<211>  694
<212>  PRT
<213>  Homo sapiens

<400>  2339

Met Ala Lys Ile Asn Thr Gln Tyr Ser His Pro Ser Arg Thr His Leu 
1               5                   10                  15      


Lys Val Lys Thr Ser Asp Arg Asp Leu Asn Arg Ala Glu Asn Gly Leu 
            20                  25                  30          


Ser Arg Ala His Ser Ser Ser Glu Glu Thr Ser Ser Val Leu Gln Pro 
        35                  40                  45              


Gly Ile Ala Met Glu Thr Arg Gly Leu Ala Asp Ser Gly Gln Gly Ser 
    50                  55                  60                  


Phe Thr Gly Gln Gly Ile Ala Arg Leu Ser Arg Leu Ile Phe Leu Leu 
65                  70                  75                  80  


Arg Arg Trp Ala Ala Arg His Val His His Gln Asp Gln Gly Pro Asp 
                85                  90                  95      


Ser Phe Pro Asp Arg Phe Arg Gly Ala Glu Leu Lys Glu Val Ser Ser 
            100                 105                 110         


Gln Glu Ser Asn Ala Gln Ala Asn Val Gly Ser Gln Glu Pro Ala Asp 
        115                 120                 125             


Arg Gly Arg Ser Ala Trp Pro Leu Ala Lys Cys Asn Thr Asn Thr Ser 
    130                 135                 140                 


Asn Asn Thr Glu Glu Glu Lys Lys Thr Lys Lys Lys Asp Ala Ile Val 
145                 150                 155                 160 


Val Asp Pro Ser Ser Asn Leu Tyr Tyr Arg Trp Leu Thr Ala Ile Ala 
                165                 170                 175     


Leu Pro Val Phe Tyr Asn Trp Tyr Leu Leu Ile Cys Arg Ala Cys Phe 
            180                 185                 190         


Asp Glu Leu Gln Ser Glu Tyr Leu Met Leu Trp Leu Val Leu Asp Tyr 
        195                 200                 205             


Ser Ala Asp Val Leu Tyr Val Leu Asp Val Leu Val Arg Ala Arg Thr 
    210                 215                 220                 


Gly Phe Leu Glu Gln Gly Leu Met Val Ser Asp Thr Asn Arg Leu Trp 
225                 230                 235                 240 


Gln His Tyr Lys Thr Thr Thr Gln Phe Lys Leu Asp Val Leu Ser Leu 
                245                 250                 255     


Val Pro Thr Asp Leu Ala Tyr Leu Lys Val Gly Thr Asn Tyr Pro Glu 
            260                 265                 270         


Val Arg Phe Asn Arg Leu Leu Lys Phe Ser Arg Leu Phe Glu Phe Phe 
        275                 280                 285             


Asp Arg Thr Glu Thr Arg Thr Asn Tyr Pro Asn Met Phe Arg Ile Gly 
    290                 295                 300                 


Asn Leu Val Leu Tyr Ile Leu Ile Ile Ile His Trp Asn Ala Cys Ile 
305                 310                 315                 320 


Tyr Phe Ala Ile Ser Lys Phe Ile Gly Phe Gly Thr Asp Ser Trp Val 
                325                 330                 335     


Tyr Pro Asn Ile Ser Ile Pro Glu His Gly Arg Leu Ser Arg Lys Tyr 
            340                 345                 350         


Ile Tyr Ser Leu Tyr Trp Ser Thr Leu Thr Leu Thr Thr Ile Gly Glu 
        355                 360                 365             


Thr Pro Pro Pro Val Lys Asp Glu Glu Tyr Leu Phe Val Val Val Asp 
    370                 375                 380                 


Phe Leu Val Gly Val Leu Ile Phe Ala Thr Ile Val Gly Asn Val Gly 
385                 390                 395                 400 


Ser Met Ile Ser Asn Met Asn Ala Ser Arg Ala Glu Phe Gln Ala Lys 
                405                 410                 415     


Ile Asp Ser Ile Lys Gln Tyr Met Gln Phe Arg Lys Val Thr Lys Asp 
            420                 425                 430         


Leu Glu Thr Arg Val Ile Arg Trp Phe Asp Tyr Leu Trp Ala Asn Lys 
        435                 440                 445             


Lys Thr Val Asp Glu Lys Glu Val Leu Lys Ser Leu Pro Asp Lys Leu 
    450                 455                 460                 


Lys Ala Glu Ile Ala Ile Asn Val His Leu Asp Thr Leu Lys Lys Val 
465                 470                 475                 480 


Arg Ile Phe Gln Asp Cys Glu Ala Gly Leu Leu Val Glu Leu Val Leu 
                485                 490                 495     


Lys Leu Arg Pro Thr Val Phe Ser Pro Gly Asp Tyr Ile Cys Lys Lys 
            500                 505                 510         


Gly Asp Ile Gly Lys Glu Met Tyr Ile Ile Asn Glu Gly Lys Leu Ala 
        515                 520                 525             


Val Val Ala Asp Asp Gly Val Thr Gln Phe Val Val Leu Ser Asp Gly 
    530                 535                 540                 


Ser Tyr Phe Gly Glu Ile Ser Ile Leu Asn Ile Lys Gly Ser Lys Ser 
545                 550                 555                 560 


Gly Asn Arg Arg Thr Ala Asn Ile Arg Ser Ile Gly Tyr Ser Asp Leu 
                565                 570                 575     


Phe Cys Leu Ser Lys Asp Asp Leu Met Glu Ala Leu Thr Glu Tyr Pro 
            580                 585                 590         


Glu Ala Lys Lys Ala Leu Glu Glu Lys Gly Arg Gln Ile Leu Met Lys 
        595                 600                 605             


Asp Asn Leu Ile Asp Glu Glu Leu Ala Arg Ala Gly Ala Asp Pro Lys 
    610                 615                 620                 


Asp Leu Glu Glu Lys Val Glu Gln Leu Gly Ser Ser Leu Asp Thr Leu 
625                 630                 635                 640 


Gln Thr Arg Phe Ala Arg Leu Leu Ala Glu Tyr Asn Ala Thr Gln Met 
                645                 650                 655     


Lys Met Lys Gln Arg Leu Ser Gln Leu Glu Ser Gln Val Lys Gly Gly 
            660                 665                 670         


Gly Asp Lys Pro Leu Ala Asp Gly Glu Val Pro Gly Asp Ala Thr Lys 
        675                 680                 685             


Thr Glu Asp Lys Gln Gln 
    690                 


<210>  2340
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  2340

Met Ala Ala Ser Pro His Thr Leu Ser Ser Arg Leu Leu Thr Gly Cys 
1               5                   10                  15      


Val Gly Gly Ser Val Trp Tyr Leu Glu Arg Arg Thr Ile Gln Asp Ser 
            20                  25                  30          


Pro His Lys Phe Leu His Leu Leu Arg Asn Val Asn Lys Gln Trp Ile 
        35                  40                  45              


Thr Phe Gln His Phe Ser Phe Leu Lys Arg Met Tyr Val Thr Gln Leu 
    50                  55                  60                  


Asn Arg Ser His Asn Gln Gln Val Arg Pro Lys Pro Glu Pro Val Ala 
65                  70                  75                  80  


Ser Pro Phe Leu Glu Lys Thr Ser Ser Gly Gln Ala Lys Ala Glu Ile 
                85                  90                  95      


Tyr Glu Met Arg Pro Leu Ser Pro Pro Ser Leu Ser Leu Ser Arg Lys 
            100                 105                 110         


Pro Asn Glu Lys Glu Leu Ile Glu Leu Glu Pro Asp Ser Val Ile Glu 
        115                 120                 125             


Asp Ser Ile Asp Val Gly Lys Glu Thr Lys Glu Glu Lys Arg Trp Lys 
    130                 135                 140                 


Glu Met Lys Leu Gln Val Tyr Asp Leu Pro Gly Ile Leu Ala Arg Leu 
145                 150                 155                 160 


Ser Lys Ile Lys Leu Thr Ala Leu Val Val Ser Thr Thr Ala Ala Gly 
                165                 170                 175     


Phe Ala Leu Ala Pro Gly Pro Phe Asp Trp Pro Cys Phe Leu Leu Thr 
            180                 185                 190         


Ser Val Gly Thr Gly Leu Ala Ser Cys Ala Ala Asn Ser Ile Asn Gln 
        195                 200                 205             


Phe Phe Glu Val Pro Phe Asp Ser Asn Met Asn Arg Thr Lys Asn Arg 
    210                 215                 220                 


Pro Leu Val Arg Gly Gln Ile Ser Pro Leu Leu Ala Val Ser Phe Ala 
225                 230                 235                 240 


Thr Cys Cys Ala Val Pro Gly Val Ala Ile Leu Thr Leu Gly Val Asn 
                245                 250                 255     


Pro Leu Thr Gly Ala Leu Gly Leu Phe Asn Ile Phe Leu Tyr Thr Cys 
            260                 265                 270         


Cys Tyr Thr Pro Leu Lys Arg Ile Ser Ile Ala Asn Thr Trp Val Gly 
        275                 280                 285             


Ala Val Val Gly Ala Ile Pro Pro Val Met Gly Trp Thr Ala Ala Thr 
    290                 295                 300                 


Gly Ser Leu Asp Ala Gly Ala Phe Leu Leu Gly Gly Ile Leu Tyr Ser 
305                 310                 315                 320 


Trp Gln Phe Pro His Phe Asn Ala Leu Ser Trp Gly Leu Arg Glu Asp 
                325                 330                 335     


Tyr Ser Arg Gly Gly Tyr Cys Met Met Ser Val Thr His Pro Gly Leu 
            340                 345                 350         


Cys Arg Arg Val Ala Leu Arg His Cys Leu Ala Leu Leu Val Leu Ser 
        355                 360                 365             


Ala Ala Ala Pro Val Leu Asp Ile Thr Thr Trp Thr Phe Pro Ile Met 
    370                 375                 380                 


Ala Leu Pro Ile Asn Ala Tyr Ile Ser Tyr Leu Gly Phe Arg Phe Tyr 
385                 390                 395                 400 


Val Asp Ala Asp Arg Arg Ser Ser Arg Arg Leu Phe Phe Cys Ser Leu 
                405                 410                 415     


Trp His Leu Pro Leu Leu Leu Leu Leu Met Leu Thr Cys Lys Arg Pro 
            420                 425                 430         


Ser Gly Gly Gly Asp Ala Gly Pro Pro Pro Ser 
        435                 440             


<210>  2341
<211>  1380
<212>  PRT
<213>  Homo sapiens

<400>  2341

Met Ala Ser Gly Arg Asp Glu Arg Pro Pro Trp Arg Leu Gly Arg Leu 
1               5                   10                  15      


Leu Leu Leu Met Cys Leu Leu Leu Leu Gly Ser Ser Ala Arg Ala Ala 
            20                  25                  30          


His Ile Lys Lys Ala Glu Ala Thr Thr Thr Thr Thr Ser Ala Gly Ala 
        35                  40                  45              


Glu Ala Ala Glu Gly Gln Phe Asp Arg Tyr Tyr His Glu Glu Glu Leu 
    50                  55                  60                  


Glu Ser Ala Leu Arg Glu Ala Ala Ala Ala Gly Leu Pro Gly Leu Ala 
65                  70                  75                  80  


Arg Leu Phe Ser Ile Gly Arg Ser Val Glu Gly Arg Pro Leu Trp Val 
                85                  90                  95      


Leu Arg Leu Thr Ala Gly Leu Gly Ser Leu Ile Pro Glu Gly Asp Ala 
            100                 105                 110         


Gly Pro Asp Ala Ala Gly Pro Asp Ala Ala Gly Pro Leu Leu Pro Gly 
        115                 120                 125             


Arg Pro Gln Val Lys Leu Val Gly Asn Met His Gly Asp Glu Thr Val 
    130                 135                 140                 


Ser Arg Gln Val Leu Ile Tyr Leu Ala Arg Glu Leu Ala Ala Gly Tyr 
145                 150                 155                 160 


Arg Arg Gly Asp Pro Arg Leu Val Arg Leu Leu Asn Thr Thr Asp Val 
                165                 170                 175     


Tyr Leu Leu Pro Ser Leu Asn Pro Asp Gly Phe Glu Arg Ala Arg Glu 
            180                 185                 190         


Gly Asp Cys Gly Phe Gly Asp Gly Gly Pro Ser Gly Ala Ser Gly Arg 
        195                 200                 205             


Asp Asn Ser Arg Gly Arg Asp Leu Asn Arg Ser Phe Pro Asp Gln Phe 
    210                 215                 220                 


Ser Thr Gly Glu Pro Pro Ala Leu Asp Glu Val Pro Glu Val Arg Ala 
225                 230                 235                 240 


Leu Ile Glu Trp Ile Arg Arg Asn Lys Phe Val Leu Ser Gly Asn Leu 
                245                 250                 255     


His Gly Gly Ser Val Val Ala Ser Tyr Pro Phe Asp Asp Ser Pro Glu 
            260                 265                 270         


His Lys Ala Thr Gly Ile Tyr Ser Lys Thr Ser Asp Asp Glu Val Phe 
        275                 280                 285             


Lys Tyr Leu Ala Lys Ala Tyr Ala Ser Asn His Pro Ile Met Lys Thr 
    290                 295                 300                 


Gly Glu Pro His Cys Pro Gly Asp Glu Asp Glu Thr Phe Lys Asp Gly 
305                 310                 315                 320 


Ile Thr Asn Gly Ala His Trp Tyr Asp Val Glu Gly Gly Met Gln Asp 
                325                 330                 335     


Tyr Asn Tyr Val Trp Ala Asn Cys Phe Glu Ile Thr Leu Glu Leu Ser 
            340                 345                 350         


Cys Cys Lys Tyr Pro Pro Ala Ser Gln Leu Arg Gln Glu Trp Glu Asn 
        355                 360                 365             


Asn Arg Glu Ser Leu Ile Thr Leu Ile Glu Lys Val His Ile Gly Val 
    370                 375                 380                 


Lys Gly Phe Val Lys Asp Ser Ile Thr Gly Ser Gly Leu Glu Asn Ala 
385                 390                 395                 400 


Thr Ile Ser Val Ala Gly Ile Asn His Asn Ile Thr Thr Gly Arg Phe 
                405                 410                 415     


Gly Asp Phe Tyr Arg Leu Leu Val Pro Gly Thr Tyr Asn Leu Thr Val 
            420                 425                 430         


Val Leu Thr Gly Tyr Met Pro Leu Thr Val Thr Asn Val Val Val Lys 
        435                 440                 445             


Glu Gly Pro Ala Thr Glu Val Asp Phe Ser Leu Arg Pro Thr Val Thr 
    450                 455                 460                 


Ser Val Ile Pro Asp Thr Thr Glu Ala Val Ser Thr Ala Ser Thr Val 
465                 470                 475                 480 


Ala Ile Pro Asn Ile Leu Ser Gly Thr Ser Ser Ser Tyr Gln Pro Ile 
                485                 490                 495     


Gln Pro Lys Asp Phe His His His His Phe Pro Asp Met Glu Ile Phe 
            500                 505                 510         


Leu Arg Arg Phe Ala Asn Glu Tyr Pro Asn Ile Thr Arg Leu Tyr Ser 
        515                 520                 525             


Leu Gly Lys Ser Val Glu Ser Arg Glu Leu Tyr Val Met Glu Ile Ser 
    530                 535                 540                 


Asp Asn Pro Gly Val His Glu Pro Gly Glu Pro Glu Phe Lys Tyr Ile 
545                 550                 555                 560 


Gly Asn Met His Gly Asn Glu Val Val Gly Arg Glu Leu Leu Leu Asn 
                565                 570                 575     


Leu Ile Glu Tyr Leu Cys Lys Asn Phe Gly Thr Asp Pro Glu Val Thr 
            580                 585                 590         


Asp Leu Val His Asn Thr Arg Ile His Leu Met Pro Ser Met Asn Pro 
        595                 600                 605             


Asp Gly Tyr Glu Lys Ser Gln Glu Gly Asp Ser Ile Ser Val Ile Gly 
    610                 615                 620                 


Arg Asn Asn Ser Asn Asn Phe Asp Leu Asn Arg Asn Phe Pro Asp Gln 
625                 630                 635                 640 


Phe Val Gln Ile Thr Asp Pro Thr Gln Pro Glu Thr Ile Ala Val Met 
                645                 650                 655     


Ser Trp Met Lys Ser Tyr Pro Phe Val Leu Ser Ala Asn Leu His Gly 
            660                 665                 670         


Gly Ser Leu Val Val Asn Tyr Pro Phe Asp Asp Asp Glu Gln Gly Leu 
        675                 680                 685             


Ala Thr Tyr Ser Lys Ser Pro Asp Asp Ala Val Phe Gln Gln Ile Ala 
    690                 695                 700                 


Leu Ser Tyr Ser Lys Glu Asn Ser Gln Met Phe Gln Gly Arg Pro Cys 
705                 710                 715                 720 


Lys Asn Met Tyr Pro Asn Glu Tyr Phe Pro His Gly Ile Thr Asn Gly 
                725                 730                 735     


Ala Ser Trp Tyr Asn Val Pro Gly Gly Met Gln Asp Trp Asn Tyr Leu 
            740                 745                 750         


Gln Thr Asn Cys Phe Glu Val Thr Ile Glu Leu Gly Cys Val Lys Tyr 
        755                 760                 765             


Pro Leu Glu Lys Glu Leu Pro Asn Phe Trp Glu Gln Asn Arg Arg Ser 
    770                 775                 780                 


Leu Ile Gln Phe Met Lys Gln Val His Gln Gly Val Arg Gly Phe Val 
785                 790                 795                 800 


Leu Asp Ala Thr Asp Gly Arg Gly Ile Leu Asn Ala Thr Ile Ser Val 
                805                 810                 815     


Ala Glu Ile Asn His Pro Val Thr Thr Tyr Lys Thr Gly Asp Tyr Trp 
            820                 825                 830         


Arg Leu Leu Val Pro Gly Thr Tyr Lys Ile Thr Ala Ser Ala Arg Gly 
        835                 840                 845             


Tyr Asn Pro Val Thr Lys Asn Val Thr Val Lys Ser Glu Gly Ala Ile 
    850                 855                 860                 


Gln Val Asn Phe Thr Leu Val Arg Ser Ser Thr Asp Ser Asn Asn Glu 
865                 870                 875                 880 


Ser Lys Lys Gly Lys Gly Ala Ser Ser Ser Thr Asn Asp Ala Ser Asp 
                885                 890                 895     


Pro Thr Thr Lys Glu Phe Glu Thr Leu Ile Lys Asp Leu Ser Ala Glu 
            900                 905                 910         


Asn Gly Leu Glu Ser Leu Met Leu Arg Ser Ser Ser Asn Leu Ala Leu 
        915                 920                 925             


Ala Leu Tyr Arg Tyr His Ser Tyr Lys Asp Leu Ser Glu Phe Leu Arg 
    930                 935                 940                 


Gly Leu Val Met Asn Tyr Pro His Ile Thr Asn Leu Thr Asn Leu Gly 
945                 950                 955                 960 


Gln Ser Thr Glu Tyr Arg His Ile Trp Ser Leu Glu Ile Ser Asn Lys 
                965                 970                 975     


Pro Asn Val Ser Glu Pro Glu Glu Pro Lys Ile Arg Phe Val Ala Gly 
            980                 985                 990         


Ile His Gly Asn Ala Pro Val Gly  Thr Glu Leu Leu Leu  Ala Leu Ala 
        995                 1000                 1005             


Glu Phe  Leu Cys Leu Asn Tyr  Lys Lys Asn Pro Ala  Val Thr Gln 
    1010                 1015                 1020             


Leu Val  Asp Arg Thr Arg Ile  Val Ile Val Pro Ser  Leu Asn Pro 
    1025                 1030                 1035             


Asp Gly  Arg Glu Arg Ala Gln  Glu Lys Asp Cys Thr  Ser Lys Ile 
    1040                 1045                 1050             


Gly Gln  Thr Asn Ala Arg Gly  Lys Asp Leu Asp Thr  Asp Phe Thr 
    1055                 1060                 1065             


Asn Asn  Ala Ser Gln Pro Glu  Thr Lys Ala Ile Ile  Glu Asn Leu 
    1070                 1075                 1080             


Ile Gln  Lys Gln Asp Phe Ser  Leu Ser Val Ala Leu  Asp Gly Gly 
    1085                 1090                 1095             


Ser Met  Leu Val Thr Tyr Pro  Tyr Asp Lys Pro Val  Gln Thr Val 
    1100                 1105                 1110             


Glu Asn  Lys Glu Thr Leu Lys  His Leu Ala Ser Leu  Tyr Ala Asn 
    1115                 1120                 1125             


Asn His  Pro Ser Met His Met  Gly Gln Pro Ser Cys  Pro Asn Lys 
    1130                 1135                 1140             


Ser Asp  Glu Asn Ile Pro Gly  Gly Val Met Arg Gly  Ala Glu Trp 
    1145                 1150                 1155             


His Ser  His Leu Gly Ser Met  Lys Asp Tyr Ser Val  Thr Tyr Gly 
    1160                 1165                 1170             


His Cys  Pro Glu Ile Thr Val  Tyr Thr Ser Cys Cys  Tyr Phe Pro 
    1175                 1180                 1185             


Ser Ala  Ala Arg Leu Pro Ser  Leu Trp Ala Asp Asn  Lys Arg Ser 
    1190                 1195                 1200             


Leu Leu  Ser Met Leu Val Glu  Val His Lys Gly Val  His Gly Phe 
    1205                 1210                 1215             


Val Lys  Asp Lys Thr Gly Lys  Pro Ile Ser Lys Ala  Val Ile Val 
    1220                 1225                 1230             


Leu Asn  Glu Gly Ile Lys Val  Gln Thr Lys Glu Gly  Gly Tyr Phe 
    1235                 1240                 1245             


His Val  Leu Leu Ala Pro Gly  Val His Asn Ile Ile  Ala Ile Ala 
    1250                 1255                 1260             


Asp Gly  Tyr Gln Gln Gln His  Ser Gln Val Phe Val  His His Asp 
    1265                 1270                 1275             


Ala Ala  Ser Ser Val Val Ile  Val Phe Asp Thr Asp  Asn Arg Ile 
    1280                 1285                 1290             


Phe Gly  Leu Pro Arg Glu Leu  Val Val Thr Val Ser  Gly Ala Thr 
    1295                 1300                 1305             


Met Ser  Ala Leu Ile Leu Thr  Ala Cys Ile Ile Trp  Cys Ile Cys 
    1310                 1315                 1320             


Ser Ile  Lys Ser Asn Arg His  Lys Asp Gly Phe His  Arg Leu Arg 
    1325                 1330                 1335             


Gln His  His Asp Glu Tyr Glu  Asp Glu Ile Arg Met  Met Ser Thr 
    1340                 1345                 1350             


Gly Ser  Lys Lys Ser Leu Leu  Ser His Glu Phe Gln  Asp Glu Thr 
    1355                 1360                 1365             


Asp Thr  Glu Glu Glu Thr Leu  Tyr Ser Ser Lys His  
    1370                 1375                 1380 


<210>  2342
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  2342

Met Ala Ser Met Gly Leu Gln Val Met Gly Ile Ala Leu Ala Val Leu 
1               5                   10                  15      


Gly Trp Leu Ala Val Met Leu Cys Cys Ala Leu Pro Met Trp Arg Val 
            20                  25                  30          


Thr Ala Phe Ile Gly Ser Asn Ile Val Thr Ser Gln Thr Ile Trp Glu 
        35                  40                  45              


Gly Leu Trp Met Asn Cys Val Val Gln Ser Thr Gly Gln Met Gln Cys 
    50                  55                  60                  


Lys Val Tyr Asp Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala 
65                  70                  75                  80  


Arg Ala Leu Val Ile Ile Ser Ile Ile Val Ala Ala Leu Gly Val Leu 
                85                  90                  95      


Leu Ser Val Val Gly Gly Lys Cys Thr Asn Cys Leu Glu Asp Glu Ser 
            100                 105                 110         


Ala Lys Ala Lys Thr Met Ile Val Ala Gly Val Val Phe Leu Leu Ala 
        115                 120                 125             


Gly Leu Met Val Ile Val Pro Val Ser Trp Thr Ala His Asn Ile Ile 
    130                 135                 140                 


Gln Asp Phe Tyr Asn Pro Leu Val Ala Ser Gly Gln Lys Arg Glu Met 
145                 150                 155                 160 


Gly Ala Ser Leu Tyr Val Gly Trp Ala Ala Ser Gly Leu Leu Leu Leu 
                165                 170                 175     


Gly Gly Gly Leu Leu Cys Cys Asn Cys Pro Pro Arg Thr Asp Lys Pro 
            180                 185                 190         


Tyr Ser Ala Lys Tyr Ser Ala Ala Arg Ser Ala Ala Ala Ser Asn Tyr 
        195                 200                 205             


Val 
    


<210>  2343
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  2343

Met Ser Met Gly Leu Glu Ile Thr Gly Thr Ala Leu Ala Val Leu Gly 
1               5                   10                  15      


Trp Leu Gly Thr Ile Val Cys Cys Ala Leu Pro Met Trp Arg Val Ser 
            20                  25                  30          


Ala Phe Ile Gly Ser Asn Ile Ile Thr Ser Gln Asn Ile Trp Glu Gly 
        35                  40                  45              


Leu Trp Met Asn Cys Val Val Gln Ser Thr Gly Gln Met Gln Cys Lys 
    50                  55                  60                  


Val Tyr Asp Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala Arg 
65                  70                  75                  80  


Ala Leu Ile Val Val Ala Ile Leu Leu Ala Ala Phe Gly Leu Leu Val 
                85                  90                  95      


Ala Leu Val Gly Ala Gln Cys Thr Asn Cys Val Gln Asp Asp Thr Ala 
            100                 105                 110         


Lys Ala Lys Ile Thr Ile Val Ala Gly Val Leu Phe Leu Leu Ala Ala 
        115                 120                 125             


Leu Leu Thr Leu Val Pro Val Ser Trp Ser Ala Asn Thr Ile Ile Arg 
    130                 135                 140                 


Asp Phe Tyr Asn Pro Val Val Pro Glu Ala Gln Lys Arg Glu Met Gly 
145                 150                 155                 160 


Ala Gly Leu Tyr Val Gly Trp Ala Ala Ala Ala Leu Gln Leu Leu Gly 
                165                 170                 175     


Gly Ala Leu Leu Cys Cys Ser Cys Pro Pro Arg Glu Lys Lys Tyr Thr 
            180                 185                 190         


Ala Thr Lys Val Val Tyr Ser Ala Pro Arg Ser Thr Gly Pro Gly Ala 
        195                 200                 205             


Ser Leu Gly Thr Gly Tyr Asp Arg Lys Asp Tyr Val 
    210                 215                 220 


<210>  2344
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  2344

Met Ala Asn Ser Gly Leu Gln Leu Leu Gly Phe Ser Met Ala Leu Leu 
1               5                   10                  15      


Gly Trp Val Gly Leu Val Ala Cys Thr Ala Ile Pro Gln Trp Gln Met 
            20                  25                  30          


Ser Ser Tyr Ala Gly Asp Asn Ile Ile Thr Ala Gln Ala Met Tyr Lys 
        35                  40                  45              


Gly Leu Trp Met Asp Cys Val Thr Gln Ser Thr Gly Met Met Ser Cys 
    50                  55                  60                  


Lys Met Tyr Asp Ser Val Leu Ala Leu Ser Ala Ala Leu Gln Ala Thr 
65                  70                  75                  80  


Arg Ala Leu Met Val Val Ser Leu Val Leu Gly Phe Leu Ala Met Phe 
                85                  90                  95      


Val Ala Thr Met Gly Met Lys Cys Thr Arg Cys Gly Gly Asp Asp Lys 
            100                 105                 110         


Val Lys Lys Ala Arg Ile Ala Met Gly Gly Gly Ile Ile Phe Ile Val 
        115                 120                 125             


Ala Gly Leu Ala Ala Leu Val Ala Cys Ser Trp Tyr Gly His Gln Ile 
    130                 135                 140                 


Val Thr Asp Phe Tyr Asn Pro Leu Ile Pro Thr Asn Ile Lys Tyr Glu 
145                 150                 155                 160 


Phe Gly Pro Ala Ile Phe Ile Gly Trp Ala Gly Ser Ala Leu Val Ile 
                165                 170                 175     


Leu Gly Gly Ala Leu Leu Ser Cys Ser Cys Pro Gly Asn Glu Ser Lys 
            180                 185                 190         


Ala Gly Tyr Arg Val Pro Arg Ser Tyr Pro Lys Ser Asn Ser Ser Lys 
        195                 200                 205             


Glu Tyr Val 
    210     


<210>  2345
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  2345

Met Ala Pro Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Thr Val Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp His Ala Met Leu Gln Ala His Arg Ala His Gln 
        35                  40                  45              


Leu Ala Ile Asp Thr Tyr Gln Glu Phe Glu Glu Thr Tyr Ile Pro Lys 
    50                  55                  60                  


Asp Gln Lys Tyr Ser Phe Leu His Asp Ser Gln Thr Ser Phe Cys Phe 
65                  70                  75                  80  


Ser Asp Ser Ile Pro Thr Pro Ser Asn Met Glu Glu Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Glu Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Arg Phe Leu Arg Ser Met Phe Ala Asn Asn Leu Val 
        115                 120                 125             


Tyr Asp Thr Ser Asp Ser Asp Asp Tyr His Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Arg Arg 
145                 150                 155                 160 


Thr Gly Gln Ile Leu Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser 
                165                 170                 175     


His Asn His Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe 
            180                 185                 190         


Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Met Val Gln Cys 
        195                 200                 205             


Arg Ser Val Glu Gly Ser Cys Gly Phe 
    210                 215         


<210>  2346
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  2346

Met Ala Arg Arg Gly Pro Gly Trp Arg Pro Leu Leu Leu Leu Val Leu 
1               5                   10                  15      


Leu Ala Gly Ala Ala Gln Gly Gly Leu Tyr Phe Arg Arg Gly Gln Thr 
            20                  25                  30          


Cys Tyr Arg Pro Leu Arg Gly Asp Gly Leu Ala Pro Leu Gly Arg Ser 
        35                  40                  45              


Thr Tyr Pro Arg Pro His Glu Tyr Leu Ser Pro Ala Asp Leu Pro Lys 
    50                  55                  60                  


Ser Trp Asp Trp Arg Asn Val Asp Gly Val Asn Tyr Ala Ser Ile Thr 
65                  70                  75                  80  


Arg Asn Gln His Ile Pro Gln Tyr Cys Gly Ser Cys Trp Ala His Ala 
                85                  90                  95      


Ser Thr Ser Ala Met Ala Asp Arg Ile Asn Ile Lys Arg Lys Gly Ala 
            100                 105                 110         


Trp Pro Ser Thr Leu Leu Ser Val Gln Asn Val Ile Asp Cys Gly Asn 
        115                 120                 125             


Ala Gly Ser Cys Glu Gly Gly Asn Asp Leu Ser Val Trp Asp Tyr Ala 
    130                 135                 140                 


His Gln His Gly Ile Pro Asp Glu Thr Cys Asn Asn Tyr Gln Ala Lys 
145                 150                 155                 160 


Asp Gln Glu Cys Asp Lys Phe Asn Gln Cys Gly Thr Cys Asn Glu Phe 
                165                 170                 175     


Lys Glu Cys His Ala Ile Arg Asn Tyr Thr Leu Trp Arg Val Gly Asp 
            180                 185                 190         


Tyr Gly Ser Leu Ser Gly Arg Glu Lys Met Met Ala Glu Ile Tyr Ala 
        195                 200                 205             


Asn Gly Pro Ile Ser Cys Gly Ile Met Ala Thr Glu Arg Leu Ala Asn 
    210                 215                 220                 


Tyr Thr Gly Gly Ile Tyr Ala Glu Tyr Gln Asp Thr Thr Tyr Ile Asn 
225                 230                 235                 240 


His Val Val Ser Val Ala Gly Trp Gly Ile Ser Asp Gly Thr Glu Tyr 
                245                 250                 255     


Trp Ile Val Arg Asn Ser Trp Gly Glu Pro Trp Gly Glu Arg Gly Trp 
            260                 265                 270         


Leu Arg Ile Val Thr Ser Thr Tyr Lys Asp Gly Lys Gly Ala Arg Tyr 
        275                 280                 285             


Asn Leu Ala Ile Glu Glu His Cys Thr Phe Gly Asp Pro Ile Val 
    290                 295                 300             


<210>  2347
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  2347

Met Asp Gln Phe Pro Glu Ser Val Thr Glu Asn Phe Glu Tyr Asp Asp 
1               5                   10                  15      


Leu Ala Glu Ala Cys Tyr Ile Gly Asp Ile Val Val Phe Gly Thr Val 
            20                  25                  30          


Phe Leu Ser Ile Phe Tyr Ser Val Ile Phe Ala Ile Gly Leu Val Gly 
        35                  40                  45              


Asn Leu Leu Val Val Phe Ala Leu Thr Asn Ser Lys Lys Pro Lys Ser 
    50                  55                  60                  


Val Thr Asp Ile Tyr Leu Leu Asn Leu Ala Leu Ser Asp Leu Leu Phe 
65                  70                  75                  80  


Val Ala Thr Leu Pro Phe Trp Thr His Tyr Leu Ile Asn Glu Lys Gly 
                85                  90                  95      


Leu His Asn Ala Met Cys Lys Phe Thr Thr Ala Phe Phe Phe Ile Gly 
            100                 105                 110         


Phe Phe Gly Ser Ile Phe Phe Ile Thr Val Ile Ser Ile Asp Arg Tyr 
        115                 120                 125             


Leu Ala Ile Val Leu Ala Ala Asn Ser Met Asn Asn Arg Thr Val Gln 
    130                 135                 140                 


His Gly Val Thr Ile Ser Leu Gly Val Trp Ala Ala Ala Ile Leu Val 
145                 150                 155                 160 


Ala Ala Pro Gln Phe Met Phe Thr Lys Gln Lys Glu Asn Glu Cys Leu 
                165                 170                 175     


Gly Asp Tyr Pro Glu Val Leu Gln Glu Ile Trp Pro Val Leu Arg Asn 
            180                 185                 190         


Val Glu Thr Asn Phe Leu Gly Phe Leu Leu Pro Leu Leu Ile Met Ser 
        195                 200                 205             


Tyr Cys Tyr Phe Arg Ile Ile Gln Thr Leu Phe Ser Cys Lys Asn His 
    210                 215                 220                 


Lys Lys Ala Lys Ala Ile Lys Leu Ile Leu Leu Val Val Ile Val Phe 
225                 230                 235                 240 


Phe Leu Phe Trp Thr Pro Tyr Asn Val Met Ile Phe Leu Glu Thr Leu 
                245                 250                 255     


Lys Leu Tyr Asp Phe Phe Pro Ser Cys Asp Met Arg Lys Asp Leu Arg 
            260                 265                 270         


Leu Ala Leu Ser Val Thr Glu Thr Val Ala Phe Ser His Cys Cys Leu 
        275                 280                 285             


Asn Pro Leu Ile Tyr Ala Phe Ala Gly Glu Lys Phe Arg Arg Tyr Leu 
    290                 295                 300                 


Tyr His Leu Tyr Gly Lys Cys Leu Ala Val Leu Cys Gly Arg Ser Val 
305                 310                 315                 320 


His Val Asp Phe Ser Ser Ser Glu Ser Gln Arg Ser Arg His Gly Ser 
                325                 330                 335     


Val Leu Ser Ser Asn Phe Thr Tyr His Thr Ser Asp Gly Asp Ala Leu 
            340                 345                 350         


Leu Leu Leu 
        355 


<210>  2348
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  2348

Met Ala Leu Leu Leu Cys Phe Val Leu Leu Cys Gly Val Val Asp Phe 
1               5                   10                  15      


Ala Arg Ser Leu Ser Ile Thr Thr Pro Glu Glu Met Ile Glu Lys Ala 
            20                  25                  30          


Lys Gly Glu Thr Ala Tyr Leu Pro Cys Lys Phe Thr Leu Ser Pro Glu 
        35                  40                  45              


Asp Gln Gly Pro Leu Asp Ile Glu Trp Leu Ile Ser Pro Ala Asp Asn 
    50                  55                  60                  


Gln Lys Val Asp Gln Val Ile Ile Leu Tyr Ser Gly Asp Lys Ile Tyr 
65                  70                  75                  80  


Asp Asp Tyr Tyr Pro Asp Leu Lys Gly Arg Val His Phe Thr Ser Asn 
                85                  90                  95      


Asp Leu Lys Ser Gly Asp Ala Ser Ile Asn Val Thr Asn Leu Gln Leu 
            100                 105                 110         


Ser Asp Ile Gly Thr Tyr Gln Cys Lys Val Lys Lys Ala Pro Gly Val 
        115                 120                 125             


Ala Asn Lys Lys Ile His Leu Val Val Leu Val Lys Pro Ser Gly Ala 
    130                 135                 140                 


Arg Cys Tyr Val Asp Gly Ser Glu Glu Ile Gly Ser Asp Phe Lys Ile 
145                 150                 155                 160 


Lys Cys Glu Pro Lys Glu Gly Ser Leu Pro Leu Gln Tyr Glu Trp Gln 
                165                 170                 175     


Lys Leu Ser Asp Ser Gln Lys Met Pro Thr Ser Trp Leu Ala Glu Met 
            180                 185                 190         


Thr Ser Ser Val Ile Ser Val Lys Asn Ala Ser Ser Glu Tyr Ser Gly 
        195                 200                 205             


Thr Tyr Ser Cys Thr Val Arg Asn Arg Val Gly Ser Asp Gln Cys Leu 
    210                 215                 220                 


Leu Arg Leu Asn Val Val Pro Pro Ser Asn Lys Ala Gly Leu Ile Ala 
225                 230                 235                 240 


Gly Ala Ile Ile Gly Thr Leu Leu Ala Leu Ala Leu Ile Gly Leu Ile 
                245                 250                 255     


Ile Phe Cys Cys Arg Lys Lys Arg Arg Glu Glu Lys Tyr Glu Lys Glu 
            260                 265                 270         


Val His His Asp Ile Arg Glu Asp Val Pro Pro Pro Lys Ser Arg Thr 
        275                 280                 285             


Ser Thr Ala Arg Ser Tyr Ile Gly Ser Asn His Ser Ser Leu Gly Ser 
    290                 295                 300                 


Met Ser Pro Ser Asn Met Glu Gly Tyr Ser Lys Thr Gln Tyr Asn Gln 
305                 310                 315                 320 


Val Pro Ser Glu Asp Phe Glu Arg Thr Pro Gln Ser Pro Thr Leu Pro 
                325                 330                 335     


Pro Ala Lys Val Ala Ala Pro Asn Leu Ser Arg Met Gly Ala Ile Pro 
            340                 345                 350         


Val Met Ile Pro Ala Gln Ser Lys Asp Gly Ser Ile Val 
        355                 360                 365 


<210>  2349
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  2349

Met Ser Ala Ser Val Val Ser Val Ile Ser Arg Phe Leu Glu Glu Tyr 
1               5                   10                  15      


Leu Ser Ser Thr Pro Gln Arg Leu Lys Leu Leu Asp Ala Tyr Leu Leu 
            20                  25                  30          


Tyr Ile Leu Leu Thr Gly Ala Leu Gln Phe Gly Tyr Cys Leu Leu Val 
        35                  40                  45              


Gly Thr Phe Pro Phe Asn Ser Phe Leu Ser Gly Phe Ile Ser Cys Val 
    50                  55                  60                  


Gly Ser Phe Ile Leu Ala Val Cys Leu Arg Ile Gln Ile Asn Pro Gln 
65                  70                  75                  80  


Asn Lys Ala Asp Phe Gln Gly Ile Ser Pro Glu Arg Ala Phe Ala Asp 
                85                  90                  95      


Phe Leu Phe Ala Ser Thr Ile Leu His Leu Val Val Met Asn Phe Val 
            100                 105                 110         


Gly 
    


<210>  2350
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  2350

Met Ala Ala Lys Ser Gln Pro Asn Ile Pro Lys Ala Lys Ser Leu Asp 
1               5                   10                  15      


Gly Val Thr Asn Asp Arg Thr Ala Ser Gln Gly Gln Trp Gly Arg Ala 
            20                  25                  30          


Trp Glu Val Asp Trp Phe Ser Leu Ala Ser Val Ile Phe Leu Leu Leu 
        35                  40                  45              


Phe Ala Pro Phe Ile Val Tyr Tyr Phe Ile Met Ala Cys Asp Gln Tyr 
    50                  55                  60                  


Ser Cys Ala Leu Thr Gly Pro Val Val Asp Ile Val Thr Gly His Ala 
65                  70                  75                  80  


Arg Leu Ser Asp Ile Trp Ala Lys Thr Pro Pro Ile Thr Arg Lys Ala 
                85                  90                  95      


Ala Gln Leu Tyr Thr Leu Trp Val Thr Phe Gln Val Leu Leu Tyr Thr 
            100                 105                 110         


Ser Leu Pro Asp Phe Cys His Lys Phe Leu Pro Gly Tyr Val Gly Gly 
        115                 120                 125             


Ile Gln Glu Gly Ala Val Thr Pro Ala Gly Val Val Asn Lys Tyr Gln 
    130                 135                 140                 


Ile Asn Gly Leu Gln Ala Trp Leu Leu Thr His Leu Leu Trp Phe Ala 
145                 150                 155                 160 


Asn Ala His Leu Leu Ser Trp Phe Ser Pro Thr Ile Ile Phe Asp Asn 
                165                 170                 175     


Trp Ile Pro Leu Leu Trp Cys Ala Asn Ile Leu Gly Tyr Ala Val Ser 
            180                 185                 190         


Thr Phe Ala Met Val Lys Gly Tyr Phe Phe Pro Thr Ser Ala Arg Asp 
        195                 200                 205             


Cys Lys Phe Thr Gly Asn Phe Phe Tyr Asn Tyr Met Met Gly Ile Glu 
    210                 215                 220                 


Phe Asn Pro Arg Ile Gly Lys Trp Phe Asp Phe Lys Leu Phe Phe Asn 
225                 230                 235                 240 


Gly Arg Pro Gly Ile Val Ala Trp Thr Leu Ile Asn Leu Ser Phe Ala 
                245                 250                 255     


Ala Lys Gln Arg Glu Leu His Ser His Val Thr Asn Ala Met Val Leu 
            260                 265                 270         


Val Asn Val Leu Gln Ala Ile Tyr Val Ile Asp Phe Phe Trp Asn Glu 
        275                 280                 285             


Thr Trp Tyr Leu Lys Thr Ile Asp Ile Cys His Asp His Phe Gly Trp 
    290                 295                 300                 


Tyr Leu Gly Trp Gly Asp Cys Val Trp Leu Pro Tyr Leu Tyr Thr Leu 
305                 310                 315                 320 


Gln Gly Leu Tyr Leu Val Tyr His Pro Val Gln Leu Ser Thr Pro His 
                325                 330                 335     


Ala Val Gly Val Leu Leu Leu Gly Leu Val Gly Tyr Tyr Ile Phe Arg 
            340                 345                 350         


Val Ala Asn His Gln Lys Asp Leu Phe Arg Arg Thr Asp Gly Arg Cys 
        355                 360                 365             


Leu Ile Trp Gly Arg Lys Pro Lys Val Ile Glu Cys Ser Tyr Thr Ser 
    370                 375                 380                 


Ala Asp Gly Gln Arg His His Ser Lys Leu Leu Val Ser Gly Phe Trp 
385                 390                 395                 400 


Gly Val Ala Arg His Phe Asn Tyr Val Gly Asp Leu Met Gly Ser Leu 
                405                 410                 415     


Ala Tyr Cys Leu Ala Cys Gly Gly Gly His Leu Leu Pro Tyr Phe Tyr 
            420                 425                 430         


Ile Ile Tyr Met Ala Ile Leu Leu Thr His Arg Cys Leu Arg Asp Glu 
        435                 440                 445             


His Arg Cys Ala Ser Lys Tyr Gly Arg Asp Trp Glu Arg Tyr Thr Ala 
    450                 455                 460                 


Ala Val Pro Tyr Arg Leu Leu Pro Gly Ile Phe 
465                 470                 475 


<210>  2351
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  2351

Met Ala Trp Arg His Leu Lys Lys Arg Ala Gln Asp Ala Val Ile Ile 
1               5                   10                  15      


Leu Gly Gly Gly Gly Leu Leu Phe Ala Ser Tyr Leu Met Ala Thr Gly 
            20                  25                  30          


Asp Glu Arg Phe Tyr Ala Glu His Leu Met Pro Thr Leu Gln Gly Leu 
        35                  40                  45              


Leu Asp Pro Glu Ser Ala His Arg Leu Ala Val Arg Phe Thr Ser Leu 
    50                  55                  60                  


Gly Leu Leu Pro Arg Ala Arg Phe Gln Asp Ser Asp Met Leu Glu Val 
65                  70                  75                  80  


Arg Val Leu Gly His Lys Phe Arg Asn Pro Val Gly Ile Ala Ala Gly 
                85                  90                  95      


Phe Asp Lys His Gly Glu Ala Val Asp Gly Leu Tyr Lys Met Gly Phe 
            100                 105                 110         


Gly Phe Val Glu Ile Gly Ser Val Thr Pro Lys Pro Gln Glu Gly Asn 
        115                 120                 125             


Pro Arg Pro Arg Val Phe Arg Leu Pro Glu Asp Gln Ala Val Ile Asn 
    130                 135                 140                 


Arg Tyr Gly Phe Asn Ser His Gly Leu Ser Val Val Glu His Arg Leu 
145                 150                 155                 160 


Arg Ala Arg Gln Gln Lys Gln Ala Lys Leu Thr Glu Asp Gly Leu Pro 
                165                 170                 175     


Leu Gly Val Asn Leu Gly Lys Asn Lys Thr Ser Val Asp Ala Ala Glu 
            180                 185                 190         


Asp Tyr Ala Glu Gly Val Arg Val Leu Gly Pro Leu Ala Asp Tyr Leu 
        195                 200                 205             


Val Val Asn Val Ser Ser Pro Asn Thr Ala Gly Leu Arg Ser Leu Gln 
    210                 215                 220                 


Gly Lys Ala Glu Leu Arg Arg Leu Leu Thr Lys Val Leu Gln Glu Arg 
225                 230                 235                 240 


Asp Gly Leu Arg Arg Val His Arg Pro Ala Val Leu Val Lys Ile Ala 
                245                 250                 255     


Pro Asp Leu Thr Ser Gln Asp Lys Glu Asp Ile Ala Ser Val Val Lys 
            260                 265                 270         


Glu Leu Gly Ile Asp Gly Leu Ile Val Thr Asn Thr Thr Val Ser Arg 
        275                 280                 285             


Pro Ala Gly Leu Gln Gly Ala Leu Arg Ser Glu Thr Gly Gly Leu Ser 
    290                 295                 300                 


Gly Lys Pro Leu Arg Asp Leu Ser Thr Gln Thr Ile Arg Glu Met Tyr 
305                 310                 315                 320 


Ala Leu Thr Gln Gly Arg Val Pro Ile Ile Gly Val Gly Gly Val Ser 
                325                 330                 335     


Ser Gly Gln Asp Ala Leu Glu Lys Ile Arg Ala Gly Ala Ser Leu Val 
            340                 345                 350         


Gln Leu Tyr Thr Ala Leu Thr Phe Trp Gly Pro Pro Val Val Gly Lys 
        355                 360                 365             


Val Lys Arg Glu Leu Glu Ala Leu Leu Lys Glu Gln Gly Phe Gly Gly 
    370                 375                 380                 


Val Thr Asp Ala Ile Gly Ala Asp His Arg Arg 
385                 390                 395 


<210>  2352
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  2352

Met Pro Arg Gln Ala Thr Ser Arg Leu Val Val Gly Glu Gly Glu Gly 
1               5                   10                  15      


Ser Gln Gly Ala Ser Gly Pro Ala Ala Thr Met Leu Arg Ser Leu Leu 
            20                  25                  30          


Leu His Ser Leu Arg Leu Cys Ala Gln Thr Ala Ser Cys Leu Val Leu 
        35                  40                  45              


Phe Pro Arg Phe Leu Gly Thr Ala Phe Met Leu Trp Leu Leu Asp Phe 
    50                  55                  60                  


Leu Cys Ile Arg Lys His Phe Leu Gly Arg Arg Arg Arg Gly Gln Pro 
65                  70                  75                  80  


Glu Pro Glu Val Glu Leu Asn Ser Glu Gly Glu Glu Val Pro Pro Asp 
                85                  90                  95      


Asp Pro Pro Ile Cys Val Ser Asp Asp Asn Arg Leu Cys Thr Leu Ala 
            100                 105                 110         


Ser Leu Lys Ala Val Trp His Gly Gln Lys Leu Asp Phe Phe Lys Gln 
        115                 120                 125             


Ala His Glu Gly Gly Pro Ala Pro Asn Ser Glu Val Val Leu Pro Asp 
    130                 135                 140                 


Gly Phe Gln Ser Gln His Ile Leu Asp Tyr Ala Gln Gly Asn Arg Pro 
145                 150                 155                 160 


Leu Val Leu Asn Phe Gly Ser Cys Thr Pro Pro Phe Met Ala Arg Met 
                165                 170                 175     


Ser Ala Phe Gln Arg Leu Val Thr Lys Tyr Gln Arg Asp Val Asp Phe 
            180                 185                 190         


Leu Ile Ile Tyr Ile Glu Glu Ala His Pro Ser Asp Gly Trp Val Thr 
        195                 200                 205             


Thr Asp Ser Pro Tyr Ile Ile Pro Gln His Arg Ser Leu Glu Asp Arg 
    210                 215                 220                 


Val Ser Ala Ala Arg Val Leu Gln Gln Gly Ala Pro Gly Cys Ala Leu 
225                 230                 235                 240 


Val Leu Asp Thr Met Ala Asn Ser Ser Ser Ser Ala Tyr Gly Ala Tyr 
                245                 250                 255     


Phe Glu Arg Leu Tyr Val Ile Gln Ser Gly Thr Ile Met Tyr Gln Gly 
            260                 265                 270         


Gly Arg Gly Pro Asp Gly Tyr Gln Val Ser Glu Leu Arg Thr Trp Leu 
        275                 280                 285             


Glu Arg Tyr Asp Glu Gln Leu His Gly Ala Arg Pro Arg Arg Val 
    290                 295                 300             


<210>  2353
<211>  408
<212>  PRT
<213>  Homo sapiens

<400>  2353

Met Trp Ala Phe Ser Glu Leu Pro Met Pro Leu Leu Ile Asn Leu Ile 
1               5                   10                  15      


Val Ser Leu Leu Gly Phe Val Ala Thr Val Thr Leu Ile Pro Ala Phe 
            20                  25                  30          


Arg Gly His Phe Ile Ala Ala Arg Leu Cys Gly Gln Asp Leu Asn Lys 
        35                  40                  45              


Thr Ser Arg Gln Gln Ile Pro Glu Ser Gln Gly Val Ile Ser Gly Ala 
    50                  55                  60                  


Val Phe Leu Ile Ile Leu Phe Cys Phe Ile Pro Phe Pro Phe Leu Asn 
65                  70                  75                  80  


Cys Phe Val Lys Glu Gln Cys Lys Ala Phe Pro His His Glu Phe Val 
                85                  90                  95      


Ala Leu Ile Gly Ala Leu Leu Ala Ile Cys Cys Met Ile Phe Leu Gly 
            100                 105                 110         


Phe Ala Asp Asp Val Leu Asn Leu Arg Trp Arg His Lys Leu Leu Leu 
        115                 120                 125             


Pro Thr Ala Ala Ser Leu Pro Leu Leu Met Val Tyr Phe Thr Asn Phe 
    130                 135                 140                 


Gly Asn Thr Thr Ile Val Val Pro Lys Pro Phe Arg Pro Ile Leu Gly 
145                 150                 155                 160 


Leu His Leu Asp Leu Gly Ile Leu Tyr Tyr Val Tyr Met Gly Leu Leu 
                165                 170                 175     


Ala Val Phe Cys Thr Asn Ala Ile Asn Ile Leu Ala Gly Ile Asn Gly 
            180                 185                 190         


Leu Glu Ala Gly Gln Ser Leu Val Ile Ser Ala Ser Ile Ile Val Phe 
        195                 200                 205             


Asn Leu Val Glu Leu Glu Gly Asp Cys Arg Asp Asp His Val Phe Ser 
    210                 215                 220                 


Leu Tyr Phe Met Ile Pro Phe Phe Phe Thr Thr Leu Gly Leu Leu Tyr 
225                 230                 235                 240 


His Asn Trp Tyr Pro Ser Arg Val Phe Val Gly Asp Thr Phe Cys Tyr 
                245                 250                 255     


Phe Ala Gly Met Thr Phe Ala Val Val Gly Ile Leu Gly His Phe Ser 
            260                 265                 270         


Lys Thr Met Leu Leu Phe Phe Met Pro Gln Val Phe Asn Phe Leu Tyr 
        275                 280                 285             


Ser Leu Pro Gln Leu Leu His Ile Ile Pro Cys Pro Arg His Arg Ile 
    290                 295                 300                 


Pro Arg Leu Asn Ile Lys Thr Gly Lys Leu Glu Met Ser Tyr Ser Lys 
305                 310                 315                 320 


Phe Lys Thr Lys Ser Leu Ser Phe Leu Gly Thr Phe Ile Leu Lys Val 
                325                 330                 335     


Ala Glu Ser Leu Gln Leu Val Thr Val His Gln Ser Glu Thr Glu Asp 
            340                 345                 350         


Gly Glu Phe Thr Glu Cys Asn Asn Met Thr Leu Ile Asn Leu Leu Leu 
        355                 360                 365             


Lys Val Leu Gly Pro Ile His Glu Arg Asn Leu Thr Leu Leu Leu Leu 
    370                 375                 380                 


Leu Leu Gln Ile Leu Gly Ser Ala Ile Thr Phe Ser Ile Arg Tyr Gln 
385                 390                 395                 400 


Leu Val Arg Leu Phe Tyr Asp Val 
                405             


<210>  2354
<211>  2012
<212>  PRT
<213>  Homo sapiens

<400>  2354

Met Trp Ile Leu Ala Leu Ser Leu Phe Gln Ser Phe Ala Asn Val Phe 
1               5                   10                  15      


Ser Glu Asp Leu His Ser Ser Leu Tyr Phe Val Asn Ala Ser Leu Gln 
            20                  25                  30          


Glu Val Val Phe Ala Ser Thr Thr Gly Thr Leu Val Pro Cys Pro Ala 
        35                  40                  45              


Ala Gly Ile Pro Pro Val Thr Leu Arg Trp Tyr Leu Ala Thr Gly Glu 
    50                  55                  60                  


Glu Ile Tyr Asp Val Pro Gly Ile Arg His Val His Pro Asn Gly Thr 
65                  70                  75                  80  


Leu Gln Ile Phe Pro Phe Pro Pro Ser Ser Phe Ser Thr Leu Ile His 
                85                  90                  95      


Asp Asn Thr Tyr Tyr Cys Thr Ala Glu Asn Pro Ser Gly Lys Ile Arg 
            100                 105                 110         


Ser Gln Asp Val His Ile Lys Ala Val Leu Arg Glu Pro Tyr Thr Val 
        115                 120                 125             


Arg Val Glu Asp Gln Lys Thr Met Arg Gly Asn Val Ala Val Phe Lys 
    130                 135                 140                 


Cys Ile Ile Pro Ser Ser Val Glu Ala Tyr Ile Thr Val Val Ser Trp 
145                 150                 155                 160 


Glu Lys Asp Thr Val Ser Leu Val Ser Gly Ser Arg Phe Leu Ile Thr 
                165                 170                 175     


Ser Thr Gly Ala Leu Tyr Ile Lys Asp Val Gln Asn Glu Asp Gly Leu 
            180                 185                 190         


Tyr Asn Tyr Arg Cys Ile Thr Arg His Arg Tyr Thr Gly Glu Thr Arg 
        195                 200                 205             


Gln Ser Asn Ser Ala Arg Leu Phe Val Ser Asp Pro Ala Asn Ser Ala 
    210                 215                 220                 


Pro Ser Ile Leu Asp Gly Phe Asp His Arg Lys Ala Met Ala Gly Gln 
225                 230                 235                 240 


Arg Val Glu Leu Pro Cys Lys Ala Leu Gly His Pro Glu Pro Asp Tyr 
                245                 250                 255     


Arg Trp Leu Lys Asp Asn Met Pro Leu Glu Leu Ser Gly Arg Phe Gln 
            260                 265                 270         


Lys Thr Val Thr Gly Leu Leu Ile Glu Asn Ile Arg Pro Ser Asp Ser 
        275                 280                 285             


Gly Ser Tyr Val Cys Glu Val Ser Asn Arg Tyr Gly Thr Ala Lys Val 
    290                 295                 300                 


Ile Gly Arg Leu Tyr Val Lys Gln Pro Leu Lys Ala Thr Ile Ser Pro 
305                 310                 315                 320 


Arg Lys Val Lys Ser Ser Val Gly Ser Gln Val Ser Leu Ser Cys Ser 
                325                 330                 335     


Val Thr Gly Thr Glu Asp Gln Glu Leu Ser Trp Tyr Arg Asn Gly Glu 
            340                 345                 350         


Ile Leu Asn Pro Gly Lys Asn Val Arg Ile Thr Gly Ile Asn His Glu 
        355                 360                 365             


Asn Leu Ile Met Asp His Met Val Lys Ser Asp Gly Gly Ala Tyr Gln 
    370                 375                 380                 


Cys Phe Val Arg Lys Asp Lys Leu Ser Ala Gln Asp Tyr Val Gln Val 
385                 390                 395                 400 


Val Leu Glu Asp Gly Thr Pro Lys Ile Ile Ser Ala Phe Ser Glu Lys 
                405                 410                 415     


Val Val Ser Pro Ala Glu Pro Val Ser Leu Met Cys Asn Val Lys Gly 
            420                 425                 430         


Thr Pro Leu Pro Thr Ile Thr Trp Thr Leu Asp Asp Asp Pro Ile Leu 
        435                 440                 445             


Lys Gly Gly Ser His Arg Ile Ser Gln Met Ile Thr Ser Glu Gly Asn 
    450                 455                 460                 


Val Val Ser Tyr Leu Asn Ile Ser Ser Ser Gln Val Arg Asp Gly Gly 
465                 470                 475                 480 


Val Tyr Arg Cys Thr Ala Asn Asn Ser Ala Gly Val Val Leu Tyr Gln 
                485                 490                 495     


Ala Arg Ile Asn Val Arg Gly Pro Ala Ser Ile Arg Pro Met Lys Asn 
            500                 505                 510         


Ile Thr Ala Ile Ala Gly Arg Asp Thr Tyr Ile His Cys Arg Val Ile 
        515                 520                 525             


Gly Tyr Pro Tyr Tyr Ser Ile Lys Trp Tyr Lys Asn Ser Asn Leu Leu 
    530                 535                 540                 


Pro Phe Asn His Arg Gln Val Ala Phe Glu Asn Asn Gly Thr Leu Lys 
545                 550                 555                 560 


Leu Ser Asp Val Gln Lys Glu Val Asp Glu Gly Glu Tyr Thr Cys Asn 
                565                 570                 575     


Val Leu Val Gln Pro Gln Leu Ser Thr Ser Gln Ser Val His Val Thr 
            580                 585                 590         


Val Lys Val Pro Pro Phe Ile Gln Pro Phe Glu Phe Pro Arg Phe Ser 
        595                 600                 605             


Ile Gly Gln Arg Val Phe Ile Pro Cys Val Val Val Ser Gly Asp Leu 
    610                 615                 620                 


Pro Ile Thr Ile Thr Trp Gln Lys Asp Gly Arg Pro Ile Pro Gly Ser 
625                 630                 635                 640 


Leu Gly Val Thr Ile Asp Asn Ile Asp Phe Thr Ser Ser Leu Arg Ile 
                645                 650                 655     


Ser Asn Leu Ser Leu Met His Asn Gly Asn Tyr Thr Cys Ile Ala Arg 
            660                 665                 670         


Asn Glu Ala Ala Ala Val Glu His Gln Ser Gln Leu Ile Val Arg Val 
        675                 680                 685             


Pro Pro Lys Phe Val Val Gln Pro Arg Asp Gln Asp Gly Ile Tyr Gly 
    690                 695                 700                 


Lys Ala Val Ile Leu Asn Cys Ser Ala Glu Gly Tyr Pro Val Pro Thr 
705                 710                 715                 720 


Ile Val Trp Lys Phe Ser Lys Gly Ala Gly Val Pro Gln Phe Gln Pro 
                725                 730                 735     


Ile Ala Leu Asn Gly Arg Ile Gln Val Leu Ser Asn Gly Ser Leu Leu 
            740                 745                 750         


Ile Lys His Val Val Glu Glu Asp Ser Gly Tyr Tyr Leu Cys Lys Val 
        755                 760                 765             


Ser Asn Asp Val Gly Ala Asp Val Ser Lys Ser Met Tyr Leu Thr Val 
    770                 775                 780                 


Lys Ile Pro Ala Met Ile Thr Ser Tyr Pro Asn Thr Thr Leu Ala Thr 
785                 790                 795                 800 


Gln Gly Gln Lys Lys Glu Met Ser Cys Thr Ala His Gly Glu Lys Pro 
                805                 810                 815     


Ile Ile Val Arg Trp Glu Lys Glu Asp Arg Ile Ile Asn Pro Glu Met 
            820                 825                 830         


Ala Arg Tyr Leu Val Ser Thr Lys Glu Val Gly Glu Glu Val Ile Ser 
        835                 840                 845             


Thr Leu Gln Ile Leu Pro Thr Val Arg Glu Asp Ser Gly Phe Phe Ser 
    850                 855                 860                 


Cys His Ala Ile Asn Ser Tyr Gly Glu Asp Arg Gly Ile Ile Gln Leu 
865                 870                 875                 880 


Thr Val Gln Glu Pro Pro Asp Pro Pro Glu Ile Glu Ile Lys Asp Val 
                885                 890                 895     


Lys Ala Arg Thr Ile Thr Leu Arg Trp Thr Met Gly Phe Asp Gly Asn 
            900                 905                 910         


Ser Pro Ile Thr Gly Tyr Asp Ile Glu Cys Lys Asn Lys Ser Asp Ser 
        915                 920                 925             


Trp Asp Ser Ala Gln Arg Thr Lys Asp Val Ser Pro Gln Leu Asn Ser 
    930                 935                 940                 


Ala Thr Ile Ile Asp Ile His Pro Ser Ser Thr Tyr Ser Ile Arg Met 
945                 950                 955                 960 


Tyr Ala Lys Asn Arg Ile Gly Lys Ser Glu Pro Ser Asn Glu Leu Thr 
                965                 970                 975     


Ile Thr Ala Asp Glu Ala Ala Pro Asp Gly Pro Pro Gln Glu Val His 
            980                 985                 990         


Leu Glu Pro Ile Ser Ser Gln Ser  Ile Arg Val Thr Trp  Lys Ala Pro 
        995                 1000                 1005             


Lys Lys  His Leu Gln Asn Gly  Ile Ile Arg Gly Tyr  Gln Ile Gly 
    1010                 1015                 1020             


Tyr Arg  Glu Tyr Ser Thr Gly  Gly Asn Phe Gln Phe  Asn Ile Ile 
    1025                 1030                 1035             


Ser Val  Asp Thr Ser Gly Asp  Ser Glu Val Tyr Thr  Leu Asp Asn 
    1040                 1045                 1050             


Leu Asn  Lys Phe Thr Gln Tyr  Gly Leu Val Val Gln  Ala Cys Asn 
    1055                 1060                 1065             


Arg Ala  Gly Thr Gly Pro Ser  Ser Gln Glu Ile Ile  Thr Thr Thr 
    1070                 1075                 1080             


Leu Glu  Asp Val Pro Ser Tyr  Pro Pro Glu Asn Val  Gln Ala Ile 
    1085                 1090                 1095             


Ala Thr  Ser Pro Glu Ser Ile  Ser Ile Ser Trp Ser  Thr Leu Ser 
    1100                 1105                 1110             


Lys Glu  Ala Leu Asn Gly Ile  Leu Gln Gly Phe Arg  Val Ile Tyr 
    1115                 1120                 1125             


Trp Ala  Asn Leu Met Asp Gly  Glu Leu Gly Glu Ile  Lys Asn Ile 
    1130                 1135                 1140             


Thr Thr  Thr Gln Pro Ser Leu  Glu Leu Asp Gly Leu  Glu Lys Tyr 
    1145                 1150                 1155             


Thr Asn  Tyr Ser Ile Gln Val  Leu Ala Phe Thr Arg  Ala Gly Asp 
    1160                 1165                 1170             


Gly Val  Arg Ser Glu Gln Ile  Phe Thr Arg Thr Lys  Glu Asp Val 
    1175                 1180                 1185             


Pro Gly  Pro Pro Ala Gly Val  Lys Ala Ala Ala Ala  Ser Ala Ser 
    1190                 1195                 1200             


Met Val  Phe Val Ser Trp Leu  Pro Pro Leu Lys Leu  Asn Gly Ile 
    1205                 1210                 1215             


Ile Arg  Lys Tyr Thr Val Phe  Cys Ser His Pro Tyr  Pro Thr Val 
    1220                 1225                 1230             


Ile Ser  Glu Phe Glu Ala Ser  Pro Asp Ser Phe Ser  Tyr Arg Ile 
    1235                 1240                 1245             


Pro Asn  Leu Ser Arg Asn Arg  Gln Tyr Ser Val Trp  Val Val Ala 
    1250                 1255                 1260             


Val Thr  Ser Ala Gly Arg Gly  Asn Ser Ser Glu Ile  Ile Thr Val 
    1265                 1270                 1275             


Glu Pro  Leu Ala Lys Ala Pro  Ala Arg Ile Leu Thr  Phe Ser Gly 
    1280                 1285                 1290             


Thr Val  Thr Thr Pro Trp Met  Lys Asp Ile Val Leu  Pro Cys Lys 
    1295                 1300                 1305             


Ala Val  Gly Asp Pro Ser Pro  Ala Val Lys Trp Met  Lys Asp Ser 
    1310                 1315                 1320             


Asn Gly  Thr Pro Ser Leu Val  Thr Ile Asp Gly Arg  Arg Ser Ile 
    1325                 1330                 1335             


Phe Ser  Asn Gly Ser Phe Ile  Ile Arg Thr Val Lys  Ala Glu Asp 
    1340                 1345                 1350             


Ser Gly  Tyr Tyr Ser Cys Ile  Ala Asn Asn Asn Trp  Gly Ser Asp 
    1355                 1360                 1365             


Glu Ile  Ile Leu Asn Leu Gln  Val Gln Val Pro Pro  Asp Gln Pro 
    1370                 1375                 1380             


Arg Leu  Thr Val Ser Lys Thr  Thr Ser Ser Ser Ile  Thr Leu Ser 
    1385                 1390                 1395             


Trp Leu  Pro Gly Asp Asn Gly  Gly Ser Ser Ile Arg  Gly Tyr Ile 
    1400                 1405                 1410             


Leu Gln  Tyr Ser Glu Asp Asn  Ser Glu Gln Trp Gly  Ser Phe Pro 
    1415                 1420                 1425             


Ile Ser  Pro Ser Glu Arg Ser  Tyr Arg Leu Glu Asn  Leu Lys Cys 
    1430                 1435                 1440             


Gly Thr  Trp Tyr Lys Phe Thr  Leu Thr Ala Gln Asn  Gly Val Gly 
    1445                 1450                 1455             


Pro Gly  Arg Ile Ser Glu Ile  Ile Glu Ala Lys Thr  Leu Gly Lys 
    1460                 1465                 1470             


Glu Pro  Gln Phe Ser Lys Glu  Gln Glu Leu Phe Ala  Ser Ile Asn 
    1475                 1480                 1485             


Thr Thr  Arg Val Arg Leu Asn  Leu Ile Gly Trp Asn  Asp Gly Gly 
    1490                 1495                 1500             


Cys Pro  Ile Thr Ser Phe Thr  Leu Glu Tyr Arg Pro  Phe Gly Thr 
    1505                 1510                 1515             


Thr Val  Trp Thr Thr Ala Gln  Arg Thr Ser Leu Ser  Lys Ser Tyr 
    1520                 1525                 1530             


Ile Leu  Tyr Asp Leu Gln Glu  Ala Thr Trp Tyr Glu  Leu Gln Met 
    1535                 1540                 1545             


Arg Val  Cys Asn Ser Ala Gly  Cys Ala Glu Lys Gln  Ala Asn Phe 
    1550                 1555                 1560             


Ala Thr  Leu Asn Tyr Asp Gly  Ser Thr Ile Pro Pro  Leu Ile Lys 
    1565                 1570                 1575             


Ser Val  Val Gln Asn Glu Glu  Gly Leu Thr Thr Asn  Glu Gly Leu 
    1580                 1585                 1590             


Lys Met  Leu Val Thr Ile Ser  Cys Ile Leu Val Gly  Val Leu Leu 
    1595                 1600                 1605             


Leu Phe  Val Leu Leu Leu Val  Val Arg Arg Arg Arg  Arg Glu Gln 
    1610                 1615                 1620             


Arg Leu  Lys Arg Leu Arg Asp  Ala Lys Ser Leu Ala  Glu Met Leu 
    1625                 1630                 1635             


Met Ser  Lys Asn Thr Arg Thr  Ser Asp Thr Leu Ser  Lys Gln Gln 
    1640                 1645                 1650             


Gln Thr  Leu Arg Met His Ile  Asp Ile Pro Arg Ala  Gln Leu Leu 
    1655                 1660                 1665             


Ile Glu  Glu Arg Asp Thr Met  Glu Thr Ile Asp Asp  Arg Ser Thr 
    1670                 1675                 1680             


Val Leu  Leu Thr Asp Ala Asp  Phe Gly Glu Ala Ala  Lys Gln Lys 
    1685                 1690                 1695             


Ser Leu  Thr Val Thr His Thr  Val His Tyr Gln Ser  Val Ser Gln 
    1700                 1705                 1710             


Ala Thr  Gly Pro Leu Val Asp  Val Ser Asp Ala Arg  Pro Gly Thr 
    1715                 1720                 1725             


Asn Pro  Thr Thr Arg Arg Asn  Ala Lys Ala Gly Pro  Thr Ala Arg 
    1730                 1735                 1740             


Asn Arg  Tyr Ala Ser Gln Trp  Thr Leu Asn Arg Pro  His Pro Thr 
    1745                 1750                 1755             


Ile Ser  Ala His Thr Leu Thr  Thr Asp Trp Arg Leu  Pro Thr Pro 
    1760                 1765                 1770             


Arg Ala  Ala Gly Ser Val Asp  Lys Glu Ser Asp Ser  Tyr Ser Val 
    1775                 1780                 1785             


Ser Pro  Ser Gln Asp Thr Asp  Arg Ala Arg Ser Ser  Met Val Ser 
    1790                 1795                 1800             


Thr Glu  Ser Ala Ser Ser Thr  Tyr Glu Glu Leu Ala  Arg Ala Tyr 
    1805                 1810                 1815             


Glu His  Ala Lys Met Glu Glu  Gln Leu Arg His Ala  Lys Phe Thr 
    1820                 1825                 1830             


Ile Thr  Glu Cys Phe Ile Ser  Asp Thr Ser Ser Glu  Gln Leu Thr 
    1835                 1840                 1845             


Ala Gly  Thr Asn Glu Tyr Thr  Asp Ser Leu Thr Ser  Ser Thr Pro 
    1850                 1855                 1860             


Ser Glu  Ser Gly Ile Cys Arg  Phe Thr Ala Ser Pro  Pro Lys Pro 
    1865                 1870                 1875             


Gln Asp  Gly Gly Arg Val Met  Asn Met Ala Val Pro  Lys Ala His 
    1880                 1885                 1890             


Arg Pro  Gly Asp Leu Ile His  Leu Pro Pro Tyr Leu  Arg Met Asp 
    1895                 1900                 1905             


Phe Leu  Leu Asn Arg Gly Gly  Pro Gly Thr Ser Arg  Asp Leu Ser 
    1910                 1915                 1920             


Leu Gly  Gln Ala Cys Leu Glu  Pro Gln Lys Ser Arg  Thr Leu Lys 
    1925                 1930                 1935             


Arg Pro  Thr Val Leu Glu Pro  Ile Pro Met Glu Ala  Ala Ser Ser 
    1940                 1945                 1950             


Ala Ser  Ser Thr Arg Glu Gly  Gln Ser Trp Gln Pro  Gly Ala Val 
    1955                 1960                 1965             


Ala Thr  Leu Pro Gln Arg Glu  Gly Ala Glu Leu Gly  Gln Ala Ala 
    1970                 1975                 1980             


Lys Met  Ser Ser Ser Gln Glu  Ser Leu Leu Asp Ser  Arg Gly His 
    1985                 1990                 1995             


Leu Lys  Gly Asn Asn Pro Tyr  Ala Lys Ser Tyr Thr  Leu Val 
    2000                 2005                 2010         


<210>  2355
<211>  743
<212>  PRT
<213>  Homo sapiens

<400>  2355

Met Ile Glu Asp Ser Gly Lys Arg Gly Asn Thr Met Ala Glu Arg Arg 
1               5                   10                  15      


Gln Leu Phe Ala Glu Met Arg Ala Gln Asp Leu Asp Arg Ile Arg Leu 
            20                  25                  30          


Ser Thr Tyr Arg Thr Ala Cys Lys Leu Arg Phe Val Gln Lys Lys Cys 
        35                  40                  45              


Asn Leu His Leu Val Asp Ile Trp Asn Val Ile Glu Ala Leu Arg Glu 
    50                  55                  60                  


Asn Ala Leu Asn Asn Leu Asp Pro Asn Thr Glu Leu Asn Val Ser Arg 
65                  70                  75                  80  


Leu Glu Ala Val Leu Ser Thr Ile Phe Tyr Gln Leu Asn Lys Arg Met 
                85                  90                  95      


Pro Thr Thr His Gln Ile His Val Glu Gln Ser Ile Ser Leu Leu Leu 
            100                 105                 110         


Asn Phe Leu Leu Ala Ala Phe Asp Pro Glu Gly His Gly Lys Ile Ser 
        115                 120                 125             


Val Phe Ala Val Lys Met Ala Leu Ala Thr Leu Cys Gly Gly Lys Ile 
    130                 135                 140                 


Met Asp Lys Leu Arg Tyr Ile Phe Ser Met Ile Ser Asp Ser Ser Gly 
145                 150                 155                 160 


Val Met Val Tyr Gly Arg Tyr Asp Gln Phe Leu Arg Glu Val Leu Lys 
                165                 170                 175     


Leu Pro Thr Ala Val Phe Glu Gly Pro Ser Phe Gly Tyr Thr Glu Gln 
            180                 185                 190         


Ser Ala Arg Ser Cys Phe Ser Gln Gln Lys Lys Val Thr Leu Asn Gly 
        195                 200                 205             


Phe Leu Asp Thr Leu Met Ser Asp Pro Pro Pro Gln Cys Leu Val Trp 
    210                 215                 220                 


Leu Pro Leu Leu His Arg Leu Ala Asn Val Glu Asn Val Phe His Pro 
225                 230                 235                 240 


Val Glu Cys Ser Tyr Cys His Ser Glu Ser Met Met Gly Phe Arg Tyr 
                245                 250                 255     


Arg Cys Gln Gln Cys His Asn Tyr Gln Leu Cys Gln Asp Cys Phe Trp 
            260                 265                 270         


Arg Gly His Ala Gly Gly Ser His Ser Asn Gln His Gln Met Lys Glu 
        275                 280                 285             


Tyr Thr Ser Trp Lys Ser Pro Ala Lys Lys Leu Thr Asn Ala Leu Ser 
    290                 295                 300                 


Lys Ser Leu Ser Cys Ala Ser Ser Arg Glu Pro Leu His Pro Met Phe 
305                 310                 315                 320 


Pro Asp Gln Pro Glu Lys Pro Leu Asn Leu Ala His Ile Val Asp Thr 
                325                 330                 335     


Trp Pro Pro Arg Pro Val Thr Ser Met Asn Asp Thr Leu Phe Ser His 
            340                 345                 350         


Ser Val Pro Ser Ser Gly Ser Pro Phe Ile Thr Arg Ser Ser Pro Pro 
        355                 360                 365             


Lys Asp Ser Glu Val Glu Gln Asn Lys Leu Leu Ala Arg Ala Ala Pro 
    370                 375                 380                 


Ala Phe Leu Lys Gly Lys Gly Ile Gln Tyr Ser Leu Asn Val Ala Asp 
385                 390                 395                 400 


Arg Leu Ala Asp Glu His Val Leu Ile Gly Leu Tyr Val Asn Met Leu 
                405                 410                 415     


Arg Asn Asn Pro Ser Cys Met Leu Glu Ser Ser Asn Arg Leu Asp Glu 
            420                 425                 430         


Glu His Arg Leu Ile Ala Arg Tyr Ala Ala Arg Leu Ala Ala Glu Ser 
        435                 440                 445             


Ser Ser Ser Gln Pro Pro Gln Gln Arg Ser Ala Pro Asp Ile Ser Phe 
    450                 455                 460                 


Thr Ile Asp Ala Asn Lys Gln Gln Arg Gln Leu Ile Ala Glu Leu Glu 
465                 470                 475                 480 


Asn Lys Asn Arg Glu Ile Leu Gln Glu Ile Gln Arg Leu Arg Leu Glu 
                485                 490                 495     


His Glu Gln Ala Ser Gln Pro Thr Pro Glu Lys Ala Gln Gln Asn Pro 
            500                 505                 510         


Thr Leu Leu Ala Glu Leu Arg Leu Leu Arg Gln Arg Lys Asp Glu Leu 
        515                 520                 525             


Glu Gln Arg Met Ser Ala Leu Gln Glu Ser Arg Arg Glu Leu Met Val 
    530                 535                 540                 


Gln Leu Glu Gly Leu Met Lys Leu Leu Lys Thr Gln Gly Ala Gly Ser 
545                 550                 555                 560 


Pro Arg Ser Ser Pro Ser His Thr Ile Ser Arg Pro Ile Pro Met Pro 
                565                 570                 575     


Ile Arg Ser Ala Ser Ala Cys Ser Thr Pro Thr His Thr Pro Gln Asp 
            580                 585                 590         


Ser Leu Thr Gly Val Gly Gly Asp Val Gln Glu Ala Phe Ala Gln Ser 
        595                 600                 605             


Ser Arg Arg Asn Leu Arg Asn Asp Leu Leu Val Ala Ala Asp Ser Ile 
    610                 615                 620                 


Thr Asn Thr Met Ser Ser Leu Val Lys Glu Leu Asn Ser Glu Val Gly 
625                 630                 635                 640 


Ser Glu Thr Glu Ser Asn Val Asp Ser Glu Phe Ala Arg Thr Gln Phe 
                645                 650                 655     


Glu Asp Leu Val Pro Ser Pro Thr Ser Glu Lys Ala Phe Leu Ala Gln 
            660                 665                 670         


Ile His Ala Arg Lys Pro Gly Tyr Ile His Ser Gly Ala Thr Thr Ser 
        675                 680                 685             


Thr Met Arg Gly Asp Met Val Thr Glu Asp Ala Asp Pro Tyr Val Gln 
    690                 695                 700                 


Pro Glu Asp Glu Asn Tyr Glu Asn Asp Ser Val Arg Gln Leu Glu Asn 
705                 710                 715                 720 


Glu Leu Gln Met Glu Glu Tyr Leu Lys Gln Lys Leu Gln Asp Glu Ala 
                725                 730                 735     


Tyr Gln Val Ser Leu Gln Gly 
            740             


<210>  2356
<211>  570
<212>  PRT
<213>  Homo sapiens

<400>  2356

Met Ile Glu Asp Ser Gly Lys Arg Gly Asn Thr Met Ala Glu Arg Arg 
1               5                   10                  15      


Gln Leu Phe Ala Glu Met Arg Ala Gln Asp Leu Asp Arg Ile Arg Leu 
            20                  25                  30          


Ser Thr Tyr Arg Thr Ala Cys Lys Leu Arg Phe Val Gln Lys Lys Cys 
        35                  40                  45              


Asn Leu His Leu Val Asp Ile Trp Asn Val Ile Glu Ala Leu Arg Glu 
    50                  55                  60                  


Asn Ala Leu Asn Asn Leu Asp Pro Asn Thr Glu Leu Asn Val Ser Arg 
65                  70                  75                  80  


Leu Glu Ala Val Leu Ser Thr Ile Phe Tyr Gln Leu Asn Lys Arg Met 
                85                  90                  95      


Pro Thr Thr His Gln Ile His Val Glu Gln Ser Ile Ser Leu Leu Leu 
            100                 105                 110         


Asn Phe Leu Leu Ala Ala Phe Asp Pro Glu Gly His Gly Lys Ile Ser 
        115                 120                 125             


Val Phe Ala Val Lys Met Ala Leu Ala Thr Leu Cys Gly Gly Lys Ile 
    130                 135                 140                 


Met Asp Lys Leu Arg Tyr Ile Phe Ser Met Ile Ser Asp Ser Ser Gly 
145                 150                 155                 160 


Val Met Val Tyr Gly Arg Tyr Asp Gln Phe Leu Arg Glu Val Leu Lys 
                165                 170                 175     


Leu Pro Thr Ala Val Phe Glu Gly Pro Ser Phe Gly Tyr Thr Glu Gln 
            180                 185                 190         


Ser Ala Arg Ser Cys Phe Ser Gln Gln Lys Lys Val Thr Leu Asn Gly 
        195                 200                 205             


Phe Leu Asp Thr Leu Met Ser Asp Pro Pro Pro Gln Cys Leu Val Trp 
    210                 215                 220                 


Leu Pro Leu Leu His Arg Leu Ala Asn Val Glu Asn Val Phe His Pro 
225                 230                 235                 240 


Val Glu Cys Ser Tyr Cys His Ser Glu Ser Met Met Gly Phe Arg Tyr 
                245                 250                 255     


Arg Cys Gln Gln Cys His Asn Tyr Gln Leu Cys Gln Asp Cys Phe Trp 
            260                 265                 270         


Arg Gly His Ala Gly Gly Ser His Ser Asn Gln His Gln Met Lys Glu 
        275                 280                 285             


Tyr Thr Ser Trp Lys Ser Pro Ala Lys Lys Leu Thr Asn Ala Leu Ser 
    290                 295                 300                 


Lys Ser Leu Ser Cys Ala Ser Ser Arg Glu Pro Leu His Pro Met Phe 
305                 310                 315                 320 


Pro Asp Gln Pro Glu Lys Pro Leu Asn Leu Ala His Ile Val Asp Thr 
                325                 330                 335     


Trp Pro Pro Arg Pro Val Thr Ser Met Asn Asp Thr Leu Phe Ser His 
            340                 345                 350         


Ser Val Pro Ser Ser Gly Ser Pro Phe Ile Thr Arg Ser Ser Pro Pro 
        355                 360                 365             


Lys Asp Ser Glu Val Glu Gln Asn Lys Leu Leu Ala Arg Ala Ala Pro 
    370                 375                 380                 


Ala Phe Leu Lys Gly Lys Gly Ile Gln Tyr Ser Leu Asn Val Ala Asp 
385                 390                 395                 400 


Arg Leu Ala Asp Glu His Val Leu Ile Gly Leu Tyr Val Asn Met Leu 
                405                 410                 415     


Arg Asn Asn Pro Ser Cys Met Leu Glu Ser Ser Asn Arg Leu Asp Glu 
            420                 425                 430         


Glu His Arg Leu Ile Ala Arg Tyr Ala Ala Arg Leu Ala Ala Glu Ser 
        435                 440                 445             


Ser Ser Ser Gln Pro Pro Gln Gln Arg Ser Ala Pro Asp Ile Ser Phe 
    450                 455                 460                 


Thr Ile Asp Ala Asn Lys Gln Gln Arg Gln Leu Ile Ala Glu Leu Glu 
465                 470                 475                 480 


Asn Lys Asn Arg Glu Ile Leu Gln Glu Ile Gln Arg Leu Arg Leu Glu 
                485                 490                 495     


His Glu Gln Ala Ser Gln Pro Thr Pro Glu Lys Ala Gln Gln Asn Pro 
            500                 505                 510         


Thr Leu Leu Ala Glu Leu Arg Leu Leu Arg Gln Arg Lys Asp Glu Leu 
        515                 520                 525             


Glu Gln Arg Met Ser Ala Leu Gln Glu Ser Arg Arg Glu Leu Met Val 
    530                 535                 540                 


Gln Leu Glu Gly Leu Met Lys Leu Leu Lys Glu Glu Glu Leu Lys Gln 
545                 550                 555                 560 


Gly Val Ser Tyr Val Pro Tyr Cys Arg Ser 
                565                 570 


<210>  2357
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  2357

Met Ile Glu Asp Ser Gly Lys Arg Gly Asn Thr Met Ala Glu Arg Arg 
1               5                   10                  15      


Gln Leu Phe Ala Glu Met Arg Ala Gln Asp Leu Asp Arg Ile Arg Leu 
            20                  25                  30          


Ser Thr Tyr Arg Thr Ala Cys Lys Leu Arg Phe Val Gln Lys Lys Cys 
        35                  40                  45              


Asn Leu His Leu Val Asp Ile Trp Asn Val Ile Glu Ala Leu Arg Glu 
    50                  55                  60                  


Asn Ala Leu Asn Asn Leu Asp Pro Asn Thr Glu Leu Asn Val Ser Arg 
65                  70                  75                  80  


Leu Glu Ala Val Leu Ser Thr Ile Phe Tyr Gln Leu Asn Lys Arg Met 
                85                  90                  95      


Pro Thr Thr His Gln Ile His Val Glu Gln Ser Ile Ser Leu Leu Leu 
            100                 105                 110         


Asn Phe Leu Leu Ala Ala Phe Asp Pro Glu Gly His Gly Lys Ile Ser 
        115                 120                 125             


Val Phe Ala Val Lys Met Ala Leu Ala Thr Leu Cys Gly Gly Lys Ile 
    130                 135                 140                 


Met Asp Lys Leu Arg Tyr Ile Phe Ser Met Ile Ser Asp Ser Ser Gly 
145                 150                 155                 160 


Val Met Val Tyr Gly Arg Tyr Asp Gln Phe Leu Arg Glu Val Leu Lys 
                165                 170                 175     


Leu Pro Thr Ala Val Phe Glu Gly Pro Ser Phe Gly Tyr Thr Glu Gln 
            180                 185                 190         


Ser Ala Arg Ser Cys Phe Ser Gln Gln Lys Lys Val Thr Leu Asn Gly 
        195                 200                 205             


Phe Leu Asp Thr Leu Met Ser Asp Pro Pro Pro Gln Cys Leu Val Trp 
    210                 215                 220                 


Leu Pro Leu Leu His Arg Leu Ala Asn Val Glu Asn Val Phe His Pro 
225                 230                 235                 240 


Val Glu Cys Ser Tyr Cys His Ser Glu Ser Met Met Gly Phe Arg Tyr 
                245                 250                 255     


Arg Cys Gln Gln Cys His Asn Tyr Gln Leu Cys Gln Asp Cys Phe Trp 
            260                 265                 270         


Arg Gly His Ala Gly Gly Ser His Ser Asn Gln His Gln Met Lys Glu 
        275                 280                 285             


Tyr Thr Ser Trp Lys Ser Pro Ala Lys Lys Leu Thr Asn Ala Leu Ser 
    290                 295                 300                 


Lys Ser Leu Ser Cys Ala Ser Ser Arg Glu Pro Leu His Pro Met Phe 
305                 310                 315                 320 


Pro Asp Gln Pro Glu Lys Pro Leu Asn Leu Ala His Ile Val Asp Thr 
                325                 330                 335     


Trp Pro Pro Arg Pro Val Thr Ser Met Asn Asp Thr Leu Phe Ser His 
            340                 345                 350         


Ser Val Pro Ser Ser Gly Ser Pro Phe Ile Thr Arg Ser Ser Asp Gly 
        355                 360                 365             


Ala Phe Gly Gly Cys Val 
    370                 


<210>  2358
<211>  770
<212>  PRT
<213>  Homo sapiens

<400>  2358

Met Arg Gly Val Trp Pro Pro Pro Val Ser Ala Leu Leu Ser Ala Leu 
1               5                   10                  15      


Gly Met Ser Thr Tyr Lys Arg Ala Thr Leu Asp Glu Glu Asp Leu Val 
            20                  25                  30          


Asp Ser Leu Ser Glu Gly Asp Ala Tyr Pro Asn Gly Leu Gln Val Asn 
        35                  40                  45              


Phe His Ser Pro Arg Ser Gly Gln Arg Cys Trp Ala Ala Arg Thr Gln 
    50                  55                  60                  


Val Glu Lys Arg Leu Val Val Leu Val Val Leu Leu Ala Ala Gly Leu 
65                  70                  75                  80  


Val Ala Cys Leu Ala Ala Leu Gly Ile Gln Tyr Gln Thr Arg Ser Pro 
                85                  90                  95      


Ser Val Cys Leu Ser Glu Ala Cys Val Ser Val Thr Ser Ser Ile Leu 
            100                 105                 110         


Ser Ser Met Asp Pro Thr Val Asp Pro Cys His Asp Phe Phe Ser Tyr 
        115                 120                 125             


Ala Cys Gly Gly Trp Ile Lys Ala Asn Pro Val Pro Asp Gly His Ser 
    130                 135                 140                 


Arg Trp Gly Thr Phe Ser Asn Leu Trp Glu His Asn Gln Ala Ile Ile 
145                 150                 155                 160 


Lys His Leu Leu Glu Asn Ser Thr Ala Ser Val Ser Glu Ala Glu Arg 
                165                 170                 175     


Lys Ala Gln Val Tyr Tyr Arg Ala Cys Met Asn Glu Thr Arg Ile Glu 
            180                 185                 190         


Glu Leu Arg Ala Lys Pro Leu Met Glu Leu Ile Glu Arg Leu Gly Gly 
        195                 200                 205             


Trp Asn Ile Thr Gly Pro Trp Ala Lys Asp Asn Phe Gln Asp Thr Leu 
    210                 215                 220                 


Gln Val Val Thr Ala His Tyr Arg Thr Ser Pro Phe Phe Ser Val Tyr 
225                 230                 235                 240 


Val Ser Ala Asp Ser Lys Asn Ser Asn Ser Asn Val Ile Gln Val Asp 
                245                 250                 255     


Gln Ser Gly Leu Gly Leu Pro Ser Arg Asp Tyr Tyr Leu Asn Lys Thr 
            260                 265                 270         


Glu Asn Glu Lys Val Leu Thr Gly Tyr Leu Asn Tyr Met Val Gln Leu 
        275                 280                 285             


Gly Lys Leu Leu Gly Gly Gly Asp Glu Glu Ala Ile Arg Pro Gln Met 
    290                 295                 300                 


Gln Gln Ile Leu Asp Phe Glu Thr Ala Leu Ala Asn Ile Thr Ile Pro 
305                 310                 315                 320 


Gln Glu Lys Arg Arg Asp Glu Glu Leu Ile Tyr His Lys Val Thr Ala 
                325                 330                 335     


Ala Glu Leu Gln Thr Leu Ala Pro Ala Ile Asn Trp Leu Pro Phe Leu 
            340                 345                 350         


Asn Thr Ile Phe Tyr Pro Val Glu Ile Asn Glu Ser Glu Pro Ile Val 
        355                 360                 365             


Val Tyr Asp Lys Glu Tyr Leu Glu Gln Ile Ser Thr Leu Ile Asn Thr 
    370                 375                 380                 


Thr Asp Arg Cys Leu Leu Asn Asn Tyr Met Ile Trp Asn Leu Val Arg 
385                 390                 395                 400 


Lys Thr Ser Ser Phe Leu Asp Gln Arg Phe Gln Asp Ala Asp Glu Lys 
                405                 410                 415     


Phe Met Glu Val Met Tyr Gly Thr Lys Lys Thr Cys Leu Pro Arg Trp 
            420                 425                 430         


Lys Phe Cys Val Ser Asp Thr Glu Asn Asn Leu Gly Phe Ala Leu Gly 
        435                 440                 445             


Pro Met Phe Val Lys Ala Thr Phe Ala Glu Asp Ser Lys Ser Ile Ala 
    450                 455                 460                 


Thr Glu Ile Ile Leu Glu Ile Lys Lys Ala Phe Glu Glu Ser Leu Ser 
465                 470                 475                 480 


Thr Leu Lys Trp Met Asp Glu Glu Thr Arg Lys Ser Ala Lys Glu Lys 
                485                 490                 495     


Ala Asp Ala Ile Tyr Asn Met Ile Gly Tyr Pro Asn Phe Ile Met Asp 
            500                 505                 510         


Pro Lys Glu Leu Asp Lys Val Phe Asn Asp Tyr Thr Ala Val Pro Asp 
        515                 520                 525             


Leu Tyr Phe Glu Asn Ala Met Arg Phe Phe Asn Phe Ser Trp Arg Val 
    530                 535                 540                 


Thr Ala Asp Gln Leu Arg Lys Ala Pro Asn Arg Asp Gln Trp Ser Met 
545                 550                 555                 560 


Thr Pro Pro Met Val Asn Ala Tyr Tyr Ser Pro Thr Lys Asn Glu Ile 
                565                 570                 575     


Val Phe Pro Ala Gly Ile Leu Gln Ala Pro Phe Tyr Thr Arg Ser Ser 
            580                 585                 590         


Pro Lys Ala Leu Asn Phe Gly Gly Ile Gly Val Val Val Gly His Glu 
        595                 600                 605             


Leu Thr His Ala Phe Asp Asp Gln Gly Arg Glu Tyr Asp Lys Asp Gly 
    610                 615                 620                 


Asn Leu Arg Pro Trp Trp Lys Asn Ser Ser Val Glu Ala Phe Lys Arg 
625                 630                 635                 640 


Gln Thr Glu Cys Met Val Glu Gln Tyr Ser Asn Tyr Ser Val Asn Gly 
                645                 650                 655     


Glu Pro Val Asn Gly Arg His Thr Leu Gly Glu Asn Ile Ala Asp Asn 
            660                 665                 670         


Gly Gly Leu Lys Ala Ala Tyr Arg Ala Tyr Gln Asn Trp Val Lys Lys 
        675                 680                 685             


Asn Gly Ala Glu His Ser Leu Pro Thr Leu Gly Leu Thr Asn Asn Gln 
    690                 695                 700                 


Leu Phe Phe Leu Gly Phe Ala Gln Val Trp Cys Ser Val Arg Thr Pro 
705                 710                 715                 720 


Glu Ser Ser His Glu Gly Leu Ile Thr Asp Pro His Ser Pro Ser Arg 
                725                 730                 735     


Phe Arg Val Ile Gly Ser Leu Ser Asn Ser Lys Glu Phe Ser Glu His 
            740                 745                 750         


Phe Arg Cys Pro Pro Gly Ser Pro Met Asn Pro Pro His Lys Cys Glu 
        755                 760                 765             


Val Trp 
    770 


<210>  2359
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  2359

Met Gly Tyr Pro Glu Val Glu Arg Arg Glu Leu Leu Pro Ala Ala Ala 
1               5                   10                  15      


Pro Arg Glu Arg Gly Ser Gln Gly Cys Gly Cys Gly Gly Ala Pro Ala 
            20                  25                  30          


Arg Ala Gly Glu Gly Asn Ser Cys Leu Leu Phe Leu Gly Phe Phe Gly 
        35                  40                  45              


Leu Ser Leu Ala Leu His Leu Leu Thr Leu Cys Cys Tyr Leu Glu Leu 
    50                  55                  60                  


Arg Ser Glu Leu Arg Arg Glu Arg Gly Ala Glu Ser Arg Leu Gly Gly 
65                  70                  75                  80  


Ser Gly Thr Pro Gly Thr Ser Gly Thr Leu Ser Ser Leu Gly Gly Leu 
                85                  90                  95      


Asp Pro Asp Ser Pro Ile Thr Ser His Leu Gly Gln Pro Ser Pro Lys 
            100                 105                 110         


Gln Gln Pro Leu Glu Pro Gly Glu Ala Ala Leu His Ser Asp Ser Gln 
        115                 120                 125             


Asp Gly His Gln Met Ala Leu Leu Asn Phe Phe Phe Pro Asp Glu Lys 
    130                 135                 140                 


Pro Tyr Ser Glu Glu Glu Ser Arg Arg Val Arg Arg Asn Lys Arg Ser 
145                 150                 155                 160 


Lys Ser Asn Glu Gly Ala Asp Gly Pro Val Lys Asn Lys Lys Lys Gly 
                165                 170                 175     


Lys Lys Ala Gly Pro Pro Gly Pro Asn Gly Pro Pro Gly Pro Pro Gly 
            180                 185                 190         


Pro Pro Gly Pro Gln Gly Pro Pro Gly Ile Pro Gly Ile Pro Gly Ile 
        195                 200                 205             


Pro Gly Thr Thr Val Met Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
    210                 215                 220                 


Pro Gln Gly Pro Pro Gly Leu Gln Gly Pro Ser Gly Ala Ala Asp Lys 
225                 230                 235                 240 


Ala Gly Thr Arg Glu Asn Gln Pro Ala Val Val His Leu Gln Gly Gln 
                245                 250                 255     


Gly Ser Ala Ile Gln Val Lys Asn Asp Leu Ser Gly Gly Val Leu Asn 
            260                 265                 270         


Asp Trp Ser Arg Ile Thr Met Asn Pro Lys Val Phe Lys Leu His Pro 
        275                 280                 285             


Arg Ser Gly Glu Leu Glu Val Leu Val Asp Gly Thr Tyr Phe Ile Tyr 
    290                 295                 300                 


Ser Gln Val Glu Val Tyr Tyr Ile Asn Phe Thr Asp Phe Ala Ser Tyr 
305                 310                 315                 320 


Glu Val Val Val Asp Glu Lys Pro Phe Leu Gln Cys Thr Arg Ser Ile 
                325                 330                 335     


Glu Thr Gly Lys Thr Asn Tyr Asn Thr Cys Tyr Thr Ala Gly Val Cys 
            340                 345                 350         


Leu Leu Lys Ala Arg Gln Lys Ile Ala Val Lys Met Val His Ala Asp 
        355                 360                 365             


Ile Ser Ile Asn Met Ser Lys His Thr Thr Phe Phe Gly Ala Ile Arg 
    370                 375                 380                 


Leu Gly Glu Ala Pro Ala Ser 
385                 390     


<210>  2360
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  2360

Met Gly Pro Thr Ser Val Pro Leu Val Lys Ala His Arg Ser Ser Val 
1               5                   10                  15      


Ser Asp Tyr Val Asn Tyr Asp Ile Ile Val Arg His Tyr Asn Tyr Thr 
            20                  25                  30          


Gly Lys Leu Asn Ile Ser Ala Asp Lys Glu Asn Ser Ile Lys Leu Thr 
        35                  40                  45              


Ser Val Val Phe Ile Leu Ile Cys Cys Phe Ile Ile Leu Glu Asn Ile 
    50                  55                  60                  


Phe Val Leu Leu Thr Ile Trp Lys Thr Lys Lys Phe His Arg Pro Met 
65                  70                  75                  80  


Tyr Tyr Phe Ile Gly Asn Leu Ala Leu Ser Asp Leu Leu Ala Gly Val 
                85                  90                  95      


Ala Tyr Thr Ala Asn Leu Leu Leu Ser Gly Ala Thr Thr Tyr Lys Leu 
            100                 105                 110         


Thr Pro Ala Gln Trp Phe Leu Arg Glu Gly Ser Met Phe Val Ala Leu 
        115                 120                 125             


Ser Ala Ser Val Phe Ser Leu Leu Ala Ile Ala Ile Glu Arg Tyr Ile 
    130                 135                 140                 


Thr Met Leu Lys Met Lys Leu His Asn Gly Ser Asn Asn Phe Arg Leu 
145                 150                 155                 160 


Phe Leu Leu Ile Ser Ala Cys Trp Val Ile Ser Leu Ile Leu Gly Gly 
                165                 170                 175     


Leu Pro Ile Met Gly Trp Asn Cys Ile Ser Ala Leu Ser Ser Cys Ser 
            180                 185                 190         


Thr Val Leu Pro Leu Tyr His Lys His Tyr Ile Leu Phe Cys Thr Thr 
        195                 200                 205             


Val Phe Thr Leu Leu Leu Leu Ser Ile Val Ile Leu Tyr Cys Arg Ile 
    210                 215                 220                 


Tyr Ser Leu Val Arg Thr Arg Ser Arg Arg Leu Thr Phe Arg Lys Asn 
225                 230                 235                 240 


Ile Ser Lys Ala Ser Arg Ser Ser Glu Lys Ser Leu Ala Leu Leu Lys 
                245                 250                 255     


Thr Val Ile Ile Val Leu Ser Val Phe Ile Ala Cys Trp Ala Pro Leu 
            260                 265                 270         


Phe Ile Leu Leu Leu Leu Asp Val Gly Cys Lys Val Lys Thr Cys Asp 
        275                 280                 285             


Ile Leu Phe Arg Ala Glu Tyr Phe Leu Val Leu Ala Val Leu Asn Ser 
    290                 295                 300                 


Gly Thr Asn Pro Ile Ile Tyr Thr Leu Thr Asn Lys Glu Met Arg Arg 
305                 310                 315                 320 


Ala Phe Ile Arg Ile Met Ser Cys Cys Lys Cys Pro Ser Gly Asp Ser 
                325                 330                 335     


Ala Gly Lys Phe Lys Arg Pro Ile Ile Ala Gly Met Glu Phe Ser Arg 
            340                 345                 350         


Ser Lys Ser Asp Asn Ser Ser His Pro Gln Lys Asp Glu Gly Asp Asn 
        355                 360                 365             


Pro Glu Thr Ile Met Ser Ser Gly Asn Val Asn Ser Ser Ser 
    370                 375                 380         


<210>  2361
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  2361

Met Ala Ala Ile Ser Thr Ser Ile Pro Val Ile Ser Gln Pro Gln Phe 
1               5                   10                  15      


Thr Ala Met Asn Glu Pro Gln Cys Phe Tyr Asn Glu Ser Ile Ala Phe 
            20                  25                  30          


Phe Tyr Asn Arg Ser Gly Lys His Leu Ala Thr Glu Trp Asn Thr Val 
        35                  40                  45              


Ser Lys Leu Val Met Gly Leu Gly Ile Thr Val Cys Ile Phe Ile Met 
    50                  55                  60                  


Leu Ala Asn Leu Leu Val Met Val Ala Ile Tyr Val Asn Arg Arg Phe 
65                  70                  75                  80  


His Phe Pro Ile Tyr Tyr Leu Met Ala Asn Leu Ala Ala Ala Asp Phe 
                85                  90                  95      


Phe Ala Gly Leu Ala Tyr Phe Tyr Leu Met Phe Asn Thr Gly Pro Asn 
            100                 105                 110         


Thr Arg Arg Leu Thr Val Ser Thr Trp Leu Leu Arg Gln Gly Leu Ile 
        115                 120                 125             


Asp Thr Ser Leu Thr Ala Ser Val Ala Asn Leu Leu Ala Ile Ala Ile 
    130                 135                 140                 


Glu Arg His Ile Thr Val Phe Arg Met Gln Leu His Thr Arg Met Ser 
145                 150                 155                 160 


Asn Arg Arg Val Val Val Val Ile Val Val Ile Trp Thr Met Ala Ile 
                165                 170                 175     


Val Met Gly Ala Ile Pro Ser Val Gly Trp Asn Cys Ile Cys Asp Ile 
            180                 185                 190         


Glu Asn Cys Ser Asn Met Ala Pro Leu Tyr Ser Asp Ser Tyr Leu Val 
        195                 200                 205             


Phe Trp Ala Ile Phe Asn Leu Val Thr Phe Val Val Met Val Val Leu 
    210                 215                 220                 


Tyr Ala His Ile Phe Gly Tyr Val Arg Gln Arg Thr Met Arg Met Ser 
225                 230                 235                 240 


Arg His Ser Ser Gly Pro Arg Arg Asn Arg Asp Thr Met Met Ser Leu 
                245                 250                 255     


Leu Lys Thr Val Val Ile Val Leu Gly Ala Phe Ile Ile Cys Trp Thr 
            260                 265                 270         


Pro Gly Leu Val Leu Leu Leu Leu Asp Val Cys Cys Pro Gln Cys Asp 
        275                 280                 285             


Val Leu Ala Tyr Glu Lys Phe Phe Leu Leu Leu Ala Glu Phe Asn Ser 
    290                 295                 300                 


Ala Met Asn Pro Ile Ile Tyr Ser Tyr Arg Asp Lys Glu Met Ser Ala 
305                 310                 315                 320 


Thr Phe Arg Gln Ile Leu Cys Cys Gln Arg Ser Glu Asn Pro Thr Gly 
                325                 330                 335     


Pro Thr Glu Gly Ser Asp Arg Ser Ala Ser Ser Leu Asn His Thr Ile 
            340                 345                 350         


Leu Ala Gly Val His Ser Asn Asp His Ser Val Val 
        355                 360                 


<210>  2362
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  2362

Met Gly Pro Pro His Ser Gly Pro Gly Gly Val Arg Val Gly Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Val Leu Gly Leu Val Ser Gly Leu Ser Leu Glu Pro 
            20                  25                  30          


Val Tyr Trp Asn Ser Ala Asn Lys Arg Phe Gln Ala Glu Gly Gly Tyr 
        35                  40                  45              


Val Leu Tyr Pro Gln Ile Gly Asp Arg Leu Asp Leu Leu Cys Pro Arg 
    50                  55                  60                  


Ala Arg Pro Pro Gly Pro His Ser Ser Pro Asn Tyr Glu Phe Tyr Lys 
65                  70                  75                  80  


Leu Tyr Leu Val Gly Gly Ala Gln Gly Arg Arg Cys Glu Ala Pro Pro 
                85                  90                  95      


Ala Pro Asn Leu Leu Leu Thr Cys Asp Arg Pro Asp Leu Asp Leu Arg 
            100                 105                 110         


Phe Thr Ile Lys Phe Gln Glu Tyr Ser Pro Asn Leu Trp Gly His Glu 
        115                 120                 125             


Phe Arg Ser His His Asp Tyr Tyr Ile Ile Ala Thr Ser Asp Gly Thr 
    130                 135                 140                 


Arg Glu Gly Leu Glu Ser Leu Gln Gly Gly Val Cys Leu Thr Arg Gly 
145                 150                 155                 160 


Met Lys Val Leu Leu Arg Val Gly Gln Ser Pro Arg Gly Gly Ala Val 
                165                 170                 175     


Pro Arg Lys Pro Val Ser Glu Met Pro Met Glu Arg Asp Arg Gly Ala 
            180                 185                 190         


Ala His Ser Leu Glu Pro Gly Lys Glu Asn Leu Pro Gly Asp Pro Thr 
        195                 200                 205             


Ser Asn Ala Thr Ser Arg Gly Ala Glu Gly Pro Leu Pro Pro Pro Ser 
    210                 215                 220                 


Met Pro Ala Val Ala Gly Ala Ala Gly Gly Leu Ala Leu Leu Leu Leu 
225                 230                 235                 240 


Gly Val Ala Gly Ala Gly Gly Ala Met Cys Trp Arg Arg Arg Arg Ala 
                245                 250                 255     


Lys Pro Ser Glu Ser Arg His Pro Gly Pro Gly Ser Phe Gly Arg Gly 
            260                 265                 270         


Gly Ser Leu Gly Leu Gly Gly Gly Gly Gly Met Gly Pro Arg Glu Ala 
        275                 280                 285             


Glu Pro Gly Glu Leu Gly Ile Ala Leu Arg Gly Gly Gly Ala Ala Asp 
    290                 295                 300                 


Pro Pro Phe Cys Pro His Tyr Glu Lys Val Ser Gly Asp Tyr Gly His 
305                 310                 315                 320 


Pro Val Tyr Ile Val Gln Asp Gly Pro Pro Gln Ser Pro Pro Asn Ile 
                325                 330                 335     


Tyr Tyr Lys Val 
            340 


<210>  2363
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  2363

Met Asp Leu Arg Arg Arg Asp Tyr His Met Glu Arg Pro Leu Leu Asn 
1               5                   10                  15      


Gln Glu His Leu Glu Glu Leu Gly Arg Trp Gly Ser Ala Pro Arg Thr 
            20                  25                  30          


His Gln Trp Arg Thr Trp Leu Gln Cys Ser Arg Ala Arg Ala Tyr Ala 
        35                  40                  45              


Leu Leu Leu Gln His Leu Pro Val Leu Val Trp Leu Pro Arg Tyr Pro 
    50                  55                  60                  


Val Arg Asp Trp Leu Leu Gly Asp Leu Leu Ser Gly Leu Ser Val Ala 
65                  70                  75                  80  


Ile Met Gln Leu Pro Gln Gly Leu Ala Tyr Ala Leu Leu Ala Gly Leu 
                85                  90                  95      


Pro Pro Val Phe Gly Leu Tyr Ser Ser Phe Tyr Pro Val Phe Ile Tyr 
            100                 105                 110         


Phe Leu Phe Gly Thr Ser Arg His Ile Ser Val Gly Thr Phe Ala Val 
        115                 120                 125             


Met Ser Val Met Val Gly Ser Val Thr Glu Ser Leu Ala Pro Gln Ala 
    130                 135                 140                 


Leu Asn Asp Ser Met Ile Asn Glu Thr Ala Arg Asp Ala Ala Arg Val 
145                 150                 155                 160 


Gln Val Ala Ser Thr Leu Ser Val Leu Val Gly Leu Phe Gln Val Gly 
                165                 170                 175     


Leu Gly Leu Ile His Phe Gly Phe Val Val Thr Tyr Leu Ser Glu Pro 
            180                 185                 190         


Leu Val Arg Gly Tyr Thr Thr Ala Ala Ala Val Gln Val Phe Val Ser 
        195                 200                 205             


Gln Leu Lys Tyr Val Phe Gly Leu His Leu Ser Ser His Ser Gly Pro 
    210                 215                 220                 


Leu Ser Leu Ile Tyr Thr Val Leu Glu Val Cys Trp Lys Leu Pro Gln 
225                 230                 235                 240 


Ser Lys Val Gly Thr Val Val Thr Ala Ala Val Ala Gly Val Val Leu 
                245                 250                 255     


Val Val Val Lys Leu Leu Asn Asp Lys Leu Gln Gln Gln Leu Pro Met 
            260                 265                 270         


Pro Ile Pro Gly Glu Leu Leu Thr Leu Ile Gly Ala Thr Gly Ile Ser 
        275                 280                 285             


Tyr Gly Met Gly Leu Lys His Arg Phe Glu Val Asp Val Val Gly Asn 
    290                 295                 300                 


Ile Pro Ala Gly Leu Val Pro Pro Val Ala Pro Asn Thr Gln Leu Phe 
305                 310                 315                 320 


Ser Lys Leu Val Gly Ser Ala Phe Thr Ile Ala Val Val Gly Phe Ala 
                325                 330                 335     


Ile Ala Ile Ser Leu Gly Lys Ile Phe Ala Leu Arg His Gly Tyr Arg 
            340                 345                 350         


Val Asp Ser Asn Gln Glu Leu Val Ala Leu Gly Leu Ser Asn Leu Ile 
        355                 360                 365             


Gly Gly Ile Phe Gln Cys Phe Pro Val Ser Cys Ser Met Ser Arg Ser 
    370                 375                 380                 


Leu Val Gln Glu Ser Thr Gly Gly Asn Ser Gln Val Ala Gly Ala Ile 
385                 390                 395                 400 


Ser Ser Leu Phe Ile Leu Leu Ile Ile Val Lys Leu Gly Glu Leu Phe 
                405                 410                 415     


His Asp Leu Pro Lys Ala Val Leu Ala Ala Ile Ile Ile Val Asn Leu 
            420                 425                 430         


Lys Gly Met Leu Arg Gln Leu Ser Asp Met Arg Ser Leu Trp Lys Ala 
        435                 440                 445             


Asn Arg Ala Asp Leu Leu Ile Trp Leu Val Thr Phe Thr Ala Thr Ile 
    450                 455                 460                 


Leu Leu Asn Leu Asp Leu Gly Leu Val Val Ala Val Ile Phe Ser Leu 
465                 470                 475                 480 


Leu Leu Val Val Val Arg Thr Gln Met Pro His Tyr Ser Val Leu Gly 
                485                 490                 495     


Gln Val Pro Asp Thr Asp Ile Tyr Arg Asp Val Ala Glu Tyr Ser Glu 
            500                 505                 510         


Ala Lys Glu Val Arg Gly Val Lys Val Phe Arg Ser Ser Ala Thr Val 
        515                 520                 525             


Tyr Phe Ala Asn Ala Glu Phe Tyr Ser Asp Ala Leu Lys Gln Arg Cys 
    530                 535                 540                 


Gly Val Asp Val Asp Phe Leu Ile Ser Gln Lys Lys Lys Leu Leu Lys 
545                 550                 555                 560 


Lys Gln Glu Gln Leu Lys Leu Lys Gln Leu Gln Lys Glu Glu Lys Leu 
                565                 570                 575     


Arg Lys Gln Ala Ala Ser Pro Lys Gly Ala Ser Val Ser Ile Asn Val 
            580                 585                 590         


Asn Thr Ser Leu Glu Asp Met Arg Ser Asn Asn Val Glu Asp Cys Lys 
        595                 600                 605             


Met Met Gln Val Ser Ser Gly Asp Lys Met Glu Asp Ala Thr Ala Asn 
    610                 615                 620                 


Gly Gln Glu Asp Ser Lys Ala Pro Asp Gly Ser Thr Leu Lys Ala Leu 
625                 630                 635                 640 


Gly Leu Pro Gln Pro Asp Phe His Ser Leu Ile Leu Asp Leu Gly Ala 
                645                 650                 655     


Leu Ser Phe Val Asp Thr Val Cys Leu Lys Ser Leu Lys Asn Ile Phe 
            660                 665                 670         


His Asp Phe Arg Glu Ile Glu Val Glu Val Tyr Met Ala Ala Cys His 
        675                 680                 685             


Ser Pro Val Val Ser Gln Leu Glu Ala Gly His Phe Phe Asp Ala Ser 
    690                 695                 700                 


Ile Thr Lys Lys His Leu Phe Ala Ser Val His Asp Ala Val Thr Phe 
705                 710                 715                 720 


Ala Leu Gln His Pro Arg Pro Val Pro Asp Ser Pro Val Ser Val Thr 
                725                 730                 735     


Arg Leu 
        


<210>  2364
<211>  3312
<212>  PRT
<213>  Homo sapiens

<400>  2364

Met Met Ala Arg Arg Pro Pro Trp Arg Gly Leu Gly Gly Arg Ser Thr 
1               5                   10                  15      


Pro Ile Leu Leu Leu Leu Leu Leu Ser Leu Phe Pro Leu Ser Gln Glu 
            20                  25                  30          


Glu Leu Gly Gly Gly Gly His Gln Gly Trp Asp Pro Gly Leu Ala Ala 
        35                  40                  45              


Thr Thr Gly Pro Arg Ala His Ile Gly Gly Gly Ala Leu Ala Leu Cys 
    50                  55                  60                  


Pro Glu Ser Ser Gly Val Arg Glu Asp Gly Gly Pro Gly Leu Gly Val 
65                  70                  75                  80  


Arg Glu Pro Ile Phe Val Gly Leu Arg Gly Arg Arg Gln Ser Ala Arg 
                85                  90                  95      


Asn Ser Arg Gly Pro Pro Glu Gln Pro Asn Glu Glu Leu Gly Ile Glu 
            100                 105                 110         


His Gly Val Gln Pro Leu Gly Ser Arg Glu Arg Glu Thr Gly Gln Gly 
        115                 120                 125             


Pro Gly Ser Val Leu Tyr Trp Arg Pro Glu Val Ser Ser Cys Gly Arg 
    130                 135                 140                 


Thr Gly Pro Leu Gln Arg Gly Ser Leu Ser Pro Gly Ala Leu Ser Ser 
145                 150                 155                 160 


Gly Val Pro Gly Ser Gly Asn Ser Ser Pro Leu Pro Ser Asp Phe Leu 
                165                 170                 175     


Ile Arg His His Gly Pro Lys Pro Val Ser Ser Gln Arg Asn Ala Gly 
            180                 185                 190         


Thr Gly Ser Arg Lys Arg Val Gly Thr Ala Arg Cys Cys Gly Glu Leu 
        195                 200                 205             


Trp Ala Thr Gly Ser Lys Gly Gln Gly Glu Arg Ala Thr Thr Ser Gly 
    210                 215                 220                 


Ala Glu Arg Thr Ala Pro Arg Arg Asn Cys Leu Pro Gly Ala Ser Gly 
225                 230                 235                 240 


Ser Gly Pro Glu Leu Asp Ser Ala Pro Arg Thr Ala Arg Thr Ala Pro 
                245                 250                 255     


Ala Ser Gly Ser Ala Pro Arg Glu Ser Arg Thr Ala Pro Glu Pro Ala 
            260                 265                 270         


Pro Lys Arg Met Arg Ser Arg Gly Leu Phe Arg Cys Arg Phe Leu Pro 
        275                 280                 285             


Gln Arg Pro Gly Pro Arg Pro Pro Gly Leu Pro Ala Arg Pro Glu Ala 
    290                 295                 300                 


Arg Lys Val Thr Ser Ala Asn Arg Ala Arg Phe Arg Arg Ala Ala Asn 
305                 310                 315                 320 


Arg His Pro Gln Phe Pro Gln Tyr Asn Tyr Gln Thr Leu Val Pro Glu 
                325                 330                 335     


Asn Glu Ala Ala Gly Thr Ala Val Leu Arg Val Val Ala Gln Asp Pro 
            340                 345                 350         


Asp Ala Gly Glu Ala Gly Arg Leu Val Tyr Ser Leu Ala Ala Leu Met 
        355                 360                 365             


Asn Ser Arg Ser Leu Glu Leu Phe Ser Ile Asp Pro Gln Ser Gly Leu 
    370                 375                 380                 


Ile Arg Thr Ala Ala Ala Leu Asp Arg Glu Ser Met Glu Arg His Tyr 
385                 390                 395                 400 


Leu Arg Val Thr Ala Gln Asp His Gly Ser Pro Arg Leu Ser Ala Thr 
                405                 410                 415     


Thr Met Val Ala Val Thr Val Ala Asp Arg Asn Asp His Ser Pro Val 
            420                 425                 430         


Phe Glu Gln Ala Gln Tyr Arg Glu Thr Leu Arg Glu Asn Val Glu Glu 
        435                 440                 445             


Gly Tyr Pro Ile Leu Gln Leu Arg Ala Thr Asp Gly Asp Ala Pro Pro 
    450                 455                 460                 


Asn Ala Asn Leu Arg Tyr Arg Phe Val Gly Pro Pro Ala Ala Arg Ala 
465                 470                 475                 480 


Ala Ala Ala Ala Ala Phe Glu Ile Asp Pro Arg Ser Gly Leu Ile Ser 
                485                 490                 495     


Thr Ser Gly Arg Val Asp Arg Glu His Met Glu Ser Tyr Glu Leu Val 
            500                 505                 510         


Val Glu Ala Ser Asp Gln Gly Gln Glu Pro Gly Pro Arg Ser Ala Thr 
        515                 520                 525             


Val Arg Val His Ile Thr Val Leu Asp Glu Asn Asp Asn Ala Pro Gln 
    530                 535                 540                 


Phe Ser Glu Lys Arg Tyr Val Ala Gln Val Arg Glu Asp Val Arg Pro 
545                 550                 555                 560 


His Thr Val Val Leu Arg Val Thr Ala Thr Asp Arg Asp Lys Asp Ala 
                565                 570                 575     


Asn Gly Leu Val His Tyr Asn Ile Ile Ser Gly Asn Ser Arg Gly His 
            580                 585                 590         


Phe Ala Ile Asp Ser Leu Thr Gly Glu Ile Gln Val Val Ala Pro Leu 
        595                 600                 605             


Asp Phe Glu Ala Glu Arg Glu Tyr Ala Leu Arg Ile Arg Ala Gln Asp 
    610                 615                 620                 


Ala Gly Arg Pro Pro Leu Ser Asn Asn Thr Gly Leu Ala Ser Ile Gln 
625                 630                 635                 640 


Val Val Asp Ile Asn Asp His Ile Pro Ile Phe Val Ser Thr Pro Phe 
                645                 650                 655     


Gln Val Ser Val Leu Glu Asn Ala Pro Leu Gly His Ser Val Ile His 
            660                 665                 670         


Ile Gln Ala Val Asp Ala Asp His Gly Glu Asn Ala Arg Leu Glu Tyr 
        675                 680                 685             


Ser Leu Thr Gly Val Ala Pro Asp Thr Pro Phe Val Ile Asn Ser Ala 
    690                 695                 700                 


Thr Gly Trp Val Ser Val Ser Gly Pro Leu Asp Arg Glu Ser Val Glu 
705                 710                 715                 720 


His Tyr Phe Phe Gly Val Glu Ala Arg Asp His Gly Ser Pro Pro Leu 
                725                 730                 735     


Ser Ala Ser Ala Ser Val Thr Val Thr Val Leu Asp Val Asn Asp Asn 
            740                 745                 750         


Arg Pro Glu Phe Thr Met Lys Glu Tyr His Leu Arg Leu Asn Glu Asp 
        755                 760                 765             


Ala Ala Val Gly Thr Ser Val Val Ser Val Thr Ala Val Asp Arg Asp 
    770                 775                 780                 


Ala Asn Ser Ala Ile Ser Tyr Gln Ile Thr Gly Gly Asn Thr Arg Asn 
785                 790                 795                 800 


Arg Phe Ala Ile Ser Thr Gln Gly Gly Val Gly Leu Val Thr Leu Ala 
                805                 810                 815     


Leu Pro Leu Asp Tyr Lys Gln Glu Arg Tyr Phe Lys Leu Val Leu Thr 
            820                 825                 830         


Ala Ser Asp Arg Ala Leu His Asp His Cys Tyr Val His Ile Asn Ile 
        835                 840                 845             


Thr Asp Ala Asn Thr His Arg Pro Val Phe Gln Ser Ala His Tyr Ser 
    850                 855                 860                 


Val Ser Val Asn Glu Asp Arg Pro Met Gly Ser Thr Ile Val Val Ile 
865                 870                 875                 880 


Ser Ala Ser Asp Asp Asp Val Gly Glu Asn Ala Arg Ile Thr Tyr Leu 
                885                 890                 895     


Leu Glu Asp Asn Leu Pro Gln Phe Arg Ile Asp Ala Asp Ser Gly Ala 
            900                 905                 910         


Ile Thr Leu Gln Ala Pro Leu Asp Tyr Glu Asp Gln Val Thr Tyr Thr 
        915                 920                 925             


Leu Ala Ile Thr Ala Arg Asp Asn Gly Ile Pro Gln Lys Ala Asp Thr 
    930                 935                 940                 


Thr Tyr Val Glu Val Met Val Asn Asp Val Asn Asp Asn Ala Pro Gln 
945                 950                 955                 960 


Phe Val Ala Ser His Tyr Thr Gly Leu Val Ser Glu Asp Ala Pro Pro 
                965                 970                 975     


Phe Thr Ser Val Leu Gln Ile Ser Ala Thr Asp Arg Asp Ala His Ala 
            980                 985                 990         


Asn Gly Arg Val Gln Tyr Thr Phe  Gln Asn Gly Glu Asp  Gly Asp Gly 
        995                 1000                 1005             


Asp Phe  Thr Ile Glu Pro Thr  Ser Gly Ile Val Arg  Thr Val Arg 
    1010                 1015                 1020             


Arg Leu  Asp Arg Glu Ala Val  Ser Val Tyr Glu Leu  Thr Ala Tyr 
    1025                 1030                 1035             


Ala Val  Asp Arg Gly Val Pro  Pro Leu Arg Thr Pro  Val Ser Ile 
    1040                 1045                 1050             


Gln Val  Met Val Gln Asp Val  Asn Asp Asn Ala Pro  Val Phe Pro 
    1055                 1060                 1065             


Ala Glu  Glu Phe Glu Val Arg  Val Lys Glu Asn Ser  Ile Val Gly 
    1070                 1075                 1080             


Ser Val  Val Ala Gln Ile Thr  Ala Val Asp Pro Asp  Glu Gly Pro 
    1085                 1090                 1095             


Asn Ala  His Ile Met Tyr Gln  Ile Val Glu Gly Asn  Ile Pro Glu 
    1100                 1105                 1110             


Leu Phe  Gln Met Asp Ile Phe  Ser Gly Glu Leu Thr  Ala Leu Ile 
    1115                 1120                 1125             


Asp Leu  Asp Tyr Glu Ala Arg  Gln Glu Tyr Val Ile  Val Val Gln 
    1130                 1135                 1140             


Ala Thr  Ser Ala Pro Leu Val  Ser Arg Ala Thr Val  His Val Arg 
    1145                 1150                 1155             


Leu Val  Asp Gln Asn Asp Asn  Ser Pro Val Leu Asn  Asn Phe Gln 
    1160                 1165                 1170             


Ile Leu  Phe Asn Asn Tyr Val  Ser Asn Arg Ser Asp  Thr Phe Pro 
    1175                 1180                 1185             


Ser Gly  Ile Ile Gly Arg Ile  Pro Ala Tyr Asp Pro  Asp Val Ser 
    1190                 1195                 1200             


Asp His  Leu Phe Tyr Ser Phe  Glu Arg Gly Asn Glu  Leu Gln Leu 
    1205                 1210                 1215             


Leu Val  Val Asn Gln Thr Ser  Gly Glu Leu Arg Leu  Ser Arg Lys 
    1220                 1225                 1230             


Leu Asp  Asn Asn Arg Pro Leu  Val Ala Ser Met Leu  Val Thr Val 
    1235                 1240                 1245             


Thr Asp  Gly Leu His Ser Val  Thr Ala Gln Cys Val  Leu Arg Val 
    1250                 1255                 1260             


Val Ile  Ile Thr Glu Glu Leu  Leu Ala Asn Ser Leu  Thr Val Arg 
    1265                 1270                 1275             


Leu Glu  Asn Met Trp Gln Glu  Arg Phe Leu Ser Pro  Leu Leu Gly 
    1280                 1285                 1290             


Arg Phe  Leu Glu Gly Val Ala  Ala Val Leu Ala Thr  Pro Ala Glu 
    1295                 1300                 1305             


Asp Val  Phe Ile Phe Asn Ile  Gln Asn Asp Thr Asp  Val Gly Gly 
    1310                 1315                 1320             


Thr Val  Leu Asn Val Ser Phe  Ser Ala Leu Ala Pro  Arg Gly Ala 
    1325                 1330                 1335             


Gly Ala  Gly Ala Ala Gly Pro  Trp Phe Ser Ser Glu  Glu Leu Gln 
    1340                 1345                 1350             


Glu Gln  Leu Tyr Val Arg Arg  Ala Ala Leu Ala Ala  Arg Ser Leu 
    1355                 1360                 1365             


Leu Asp  Val Leu Pro Phe Asp  Asp Asn Val Cys Leu  Arg Glu Pro 
    1370                 1375                 1380             


Cys Glu  Asn Tyr Met Lys Cys  Val Ser Val Leu Arg  Phe Asp Ser 
    1385                 1390                 1395             


Ser Ala  Pro Phe Leu Ala Ser  Ala Ser Thr Leu Phe  Arg Pro Ile 
    1400                 1405                 1410             


Gln Pro  Ile Ala Gly Leu Arg  Cys Arg Cys Pro Pro  Gly Phe Thr 
    1415                 1420                 1425             


Gly Asp  Phe Cys Glu Thr Glu  Leu Asp Leu Cys Tyr  Ser Asn Pro 
    1430                 1435                 1440             


Cys Arg  Asn Gly Gly Ala Cys  Ala Arg Arg Glu Gly  Gly Tyr Thr 
    1445                 1450                 1455             


Cys Val  Cys Arg Pro Arg Phe  Thr Gly Glu Asp Cys  Glu Leu Asp 
    1460                 1465                 1470             


Thr Glu  Ala Gly Arg Cys Val  Pro Gly Val Cys Arg  Asn Gly Gly 
    1475                 1480                 1485             


Thr Cys  Thr Asp Ala Pro Asn  Gly Gly Phe Arg Cys  Gln Cys Pro 
    1490                 1495                 1500             


Ala Gly  Gly Ala Phe Glu Gly  Pro Arg Cys Glu Val  Ala Ala Arg 
    1505                 1510                 1515             


Ser Phe  Pro Pro Ser Ser Phe  Val Met Phe Arg Gly  Leu Arg Gln 
    1520                 1525                 1530             


Arg Phe  His Leu Thr Leu Ser  Leu Ser Phe Ala Thr  Val Gln Gln 
    1535                 1540                 1545             


Ser Gly  Leu Leu Phe Tyr Asn  Gly Arg Leu Asn Glu  Lys His Asp 
    1550                 1555                 1560             


Phe Leu  Ala Leu Glu Leu Val  Ala Gly Gln Val Arg  Leu Thr Tyr 
    1565                 1570                 1575             


Ser Thr  Gly Glu Ser Asn Thr  Val Val Ser Pro Thr  Val Pro Gly 
    1580                 1585                 1590             


Gly Leu  Ser Asp Gly Gln Trp  His Thr Val His Leu  Arg Tyr Tyr 
    1595                 1600                 1605             


Asn Lys  Pro Arg Thr Asp Ala  Leu Gly Gly Ala Gln  Gly Pro Ser 
    1610                 1615                 1620             


Lys Asp  Lys Val Ala Val Leu  Ser Val Asp Asp Cys  Asp Val Ala 
    1625                 1630                 1635             


Val Ala  Leu Gln Phe Gly Ala  Glu Ile Gly Asn Tyr  Ser Cys Ala 
    1640                 1645                 1650             


Ala Ala  Gly Val Gln Thr Ser  Ser Lys Lys Ser Leu  Asp Leu Thr 
    1655                 1660                 1665             


Gly Pro  Leu Leu Leu Gly Gly  Val Pro Asn Leu Pro  Glu Asn Phe 
    1670                 1675                 1680             


Pro Val  Ser His Lys Asp Phe  Ile Gly Cys Met Arg  Asp Leu His 
    1685                 1690                 1695             


Ile Asp  Gly Arg Arg Val Asp  Met Ala Ala Phe Val  Ala Asn Asn 
    1700                 1705                 1710             


Gly Thr  Met Ala Gly Cys Gln  Ala Lys Leu His Phe  Cys Asp Ser 
    1715                 1720                 1725             


Gly Pro  Cys Lys Asn Ser Gly  Phe Cys Ser Glu Arg  Trp Gly Ser 
    1730                 1735                 1740             


Phe Ser  Cys Asp Cys Pro Val  Gly Phe Gly Gly Lys  Asp Cys Gln 
    1745                 1750                 1755             


Leu Thr  Met Ala His Pro His  His Phe Arg Gly Asn  Gly Thr Leu 
    1760                 1765                 1770             


Ser Trp  Asn Phe Gly Ser Asp  Met Ala Val Ser Val  Pro Trp Tyr 
    1775                 1780                 1785             


Leu Gly  Leu Ala Phe Arg Thr  Arg Ala Thr Gln Gly  Val Leu Met 
    1790                 1795                 1800             


Gln Val  Gln Ala Gly Pro His  Ser Thr Leu Leu Cys  Gln Leu Asp 
    1805                 1810                 1815             


Arg Gly  Leu Leu Ser Val Thr  Val Thr Arg Gly Ser  Gly Arg Ala 
    1820                 1825                 1830             


Ser His  Leu Leu Leu Asp Gln  Val Thr Val Ser Asp  Gly Arg Trp 
    1835                 1840                 1845             


His Asp  Leu Arg Leu Glu Leu  Gln Glu Glu Pro Gly  Gly Arg Arg 
    1850                 1855                 1860             


Gly His  His Val Leu Met Val  Ser Leu Asp Phe Ser  Leu Phe Gln 
    1865                 1870                 1875             


Asp Thr  Met Ala Val Gly Ser  Glu Leu Gln Gly Leu  Lys Val Lys 
    1880                 1885                 1890             


Gln Leu  His Val Gly Gly Leu  Pro Pro Gly Ser Ala  Glu Glu Ala 
    1895                 1900                 1905             


Pro Gln  Gly Leu Val Gly Cys  Ile Gln Gly Val Trp  Leu Gly Ser 
    1910                 1915                 1920             


Thr Pro  Ser Gly Ser Pro Ala  Leu Leu Pro Pro Ser  His Arg Val 
    1925                 1930                 1935             


Asn Ala  Glu Pro Gly Cys Val  Val Thr Asn Ala Cys  Ala Ser Gly 
    1940                 1945                 1950             


Pro Cys  Pro Pro His Ala Asp  Cys Arg Asp Leu Trp  Gln Thr Phe 
    1955                 1960                 1965             


Ser Cys  Thr Cys Gln Pro Gly  Tyr Tyr Gly Pro Gly  Cys Val Asp 
    1970                 1975                 1980             


Ala Cys  Leu Leu Asn Pro Cys  Gln Asn Gln Gly Ser  Cys Arg His 
    1985                 1990                 1995             


Leu Pro  Gly Ala Pro His Gly  Tyr Thr Cys Asp Cys  Val Gly Gly 
    2000                 2005                 2010             


Tyr Phe  Gly His His Cys Glu  His Arg Met Asp Gln  Gln Cys Pro 
    2015                 2020                 2025             


Arg Gly  Trp Trp Gly Ser Pro  Thr Cys Gly Pro Cys  Asn Cys Asp 
    2030                 2035                 2040             


Val His  Lys Gly Phe Asp Pro  Asn Cys Asn Lys Thr  Asn Gly Gln 
    2045                 2050                 2055             


Cys His  Cys Lys Glu Phe His  Tyr Arg Pro Arg Gly  Ser Asp Ser 
    2060                 2065                 2070             


Cys Leu  Pro Cys Asp Cys Tyr  Pro Val Gly Ser Thr  Ser Arg Ser 
    2075                 2080                 2085             


Cys Ala  Pro His Ser Gly Gln  Cys Pro Cys Arg Pro  Gly Ala Leu 
    2090                 2095                 2100             


Gly Arg  Gln Cys Asn Ser Cys  Asp Ser Pro Phe Ala  Glu Val Thr 
    2105                 2110                 2115             


Ala Ser  Gly Cys Arg Val Leu  Tyr Asp Ala Cys Pro  Lys Ser Leu 
    2120                 2125                 2130             


Arg Ser  Gly Val Trp Trp Pro  Gln Thr Lys Phe Gly  Val Leu Ala 
    2135                 2140                 2145             


Thr Val  Pro Cys Pro Arg Gly  Ala Leu Gly Ala Ala  Val Arg Leu 
    2150                 2155                 2160             


Cys Asp  Glu Ala Gln Gly Trp  Leu Glu Pro Asp Leu  Phe Asn Cys 
    2165                 2170                 2175             


Thr Ser  Pro Ala Phe Arg Glu  Leu Ser Leu Leu Leu  Asp Gly Leu 
    2180                 2185                 2190             


Glu Leu  Asn Lys Thr Ala Leu  Asp Thr Met Glu Ala  Lys Lys Leu 
    2195                 2200                 2205             


Ala Gln  Arg Leu Arg Glu Val  Thr Gly His Thr Asp  His Tyr Phe 
    2210                 2215                 2220             


Ser Gln  Asp Val Arg Val Thr  Ala Arg Leu Leu Ala  His Leu Leu 
    2225                 2230                 2235             


Ala Phe  Glu Ser His Gln Gln  Gly Phe Gly Leu Thr  Ala Thr Gln 
    2240                 2245                 2250             


Asp Ala  His Phe Asn Glu Asn  Leu Leu Trp Ala Gly  Ser Ala Leu 
    2255                 2260                 2265             


Leu Ala  Pro Glu Thr Gly Asp  Leu Trp Ala Ala Leu  Gly Gln Arg 
    2270                 2275                 2280             


Ala Pro  Gly Gly Ser Pro Gly  Ser Ala Gly Leu Val  Arg His Leu 
    2285                 2290                 2295             


Glu Glu  Tyr Ala Ala Thr Leu  Ala Arg Asn Met Glu  Leu Thr Tyr 
    2300                 2305                 2310             


Leu Asn  Pro Met Gly Leu Val  Thr Pro Asn Ile Met  Leu Ser Ile 
    2315                 2320                 2325             


Asp Arg  Met Glu His Pro Ser  Ser Pro Arg Gly Ala  Arg Arg Tyr 
    2330                 2335                 2340             


Pro Arg  Tyr His Ser Asn Leu  Phe Arg Gly Gln Asp  Ala Trp Asp 
    2345                 2350                 2355             


Pro His  Thr His Val Leu Leu  Pro Ser Gln Ser Pro  Arg Pro Ser 
    2360                 2365                 2370             


Pro Ser  Glu Val Leu Pro Thr  Ser Ser Ser Ile Glu  Asn Ser Thr 
    2375                 2380                 2385             


Thr Ser  Ser Val Val Pro Pro  Pro Ala Pro Pro Glu  Pro Glu Pro 
    2390                 2395                 2400             


Gly Ile  Ser Ile Ile Ile Leu  Leu Val Tyr Arg Thr  Leu Gly Gly 
    2405                 2410                 2415             


Leu Leu  Pro Ala Gln Phe Gln  Ala Glu Arg Arg Gly  Ala Arg Leu 
    2420                 2425                 2430             


Pro Gln  Asn Pro Val Met Asn  Ser Pro Val Val Ser  Val Ala Val 
    2435                 2440                 2445             


Phe His  Gly Arg Asn Phe Leu  Arg Gly Ile Leu Glu  Ser Pro Ile 
    2450                 2455                 2460             


Ser Leu  Glu Phe Arg Leu Leu  Gln Thr Ala Asn Arg  Ser Lys Ala 
    2465                 2470                 2475             


Ile Cys  Val Gln Trp Asp Pro  Pro Gly Leu Ala Glu  Gln His Gly 
    2480                 2485                 2490             


Val Trp  Thr Ala Arg Asp Cys  Glu Leu Val His Arg  Asn Gly Ser 
    2495                 2500                 2505             


His Ala  Arg Cys Arg Cys Ser  Arg Thr Gly Thr Phe  Gly Val Leu 
    2510                 2515                 2520             


Met Asp  Ala Ser Pro Arg Glu  Arg Leu Glu Gly Asp  Leu Glu Leu 
    2525                 2530                 2535             


Leu Ala  Val Phe Thr His Val  Val Val Ala Val Ser  Val Ala Ala 
    2540                 2545                 2550             


Leu Val  Leu Thr Ala Ala Ile  Leu Leu Ser Leu Arg  Ser Leu Lys 
    2555                 2560                 2565             


Ser Asn  Val Arg Gly Ile His  Ala Asn Val Ala Ala  Ala Leu Gly 
    2570                 2575                 2580             


Val Ala  Glu Leu Leu Phe Leu  Leu Gly Ile His Arg  Thr His Asn 
    2585                 2590                 2595             


Gln Leu  Val Cys Thr Ala Val  Ala Ile Leu Leu His  Tyr Phe Phe 
    2600                 2605                 2610             


Leu Ser  Thr Phe Ala Trp Leu  Phe Val Gln Gly Leu  His Leu Tyr 
    2615                 2620                 2625             


Arg Met  Gln Val Glu Pro Arg  Asn Val Asp Arg Gly  Ala Met Arg 
    2630                 2635                 2640             


Phe Tyr  His Ala Leu Gly Trp  Gly Val Pro Ala Val  Leu Leu Gly 
    2645                 2650                 2655             


Leu Ala  Val Gly Leu Asp Pro  Glu Gly Tyr Gly Asn  Pro Asp Phe 
    2660                 2665                 2670             


Cys Trp  Ile Ser Val His Glu  Pro Leu Ile Trp Ser  Phe Ala Gly 
    2675                 2680                 2685             


Pro Val  Val Leu Val Ile Val  Met Asn Gly Thr Met  Phe Leu Leu 
    2690                 2695                 2700             


Ala Ala  Arg Thr Ser Cys Ser  Thr Gly Gln Arg Glu  Ala Lys Lys 
    2705                 2710                 2715             


Thr Ser  Ala Leu Thr Leu Arg  Ser Ser Phe Leu Leu  Leu Leu Leu 
    2720                 2725                 2730             


Val Ser  Ala Ser Trp Leu Phe  Gly Leu Leu Ala Val  Asn His Ser 
    2735                 2740                 2745             


Ile Leu  Ala Phe His Tyr Leu  His Ala Gly Leu Cys  Gly Leu Gln 
    2750                 2755                 2760             


Gly Leu  Ala Val Leu Leu Leu  Phe Cys Val Leu Asn  Ala Asp Ala 
    2765                 2770                 2775             


Arg Ala  Ala Trp Met Pro Ala  Cys Leu Gly Arg Lys  Ala Ala Pro 
    2780                 2785                 2790             


Glu Glu  Ala Arg Pro Ala Pro  Gly Leu Gly Pro Gly  Ala Tyr Asn 
    2795                 2800                 2805             


Asn Thr  Ala Leu Phe Glu Glu  Ser Gly Leu Ile Arg  Ile Thr Leu 
    2810                 2815                 2820             


Gly Ala  Ser Thr Val Ser Ser  Val Ser Ser Ala Arg  Ser Gly Arg 
    2825                 2830                 2835             


Thr Gln  Asp Gln Asp Ser Gln  Arg Gly Arg Ser Tyr  Leu Arg Asp 
    2840                 2845                 2850             


Asn Val  Leu Val Arg His Gly  Ser Ala Ala Asp His  Thr Asp His 
    2855                 2860                 2865             


Ser Leu  Gln Ala His Ala Gly  Pro Thr Asp Leu Asp  Val Ala Met 
    2870                 2875                 2880             


Phe His  Arg Asp Ala Gly Ala  Asp Ser Asp Ser Asp  Ser Asp Leu 
    2885                 2890                 2895             


Ser Leu  Glu Glu Glu Arg Ser  Leu Ser Ile Pro Ser  Ser Glu Ser 
    2900                 2905                 2910             


Glu Asp  Asn Gly Arg Thr Arg  Gly Arg Phe Gln Arg  Pro Leu Cys 
    2915                 2920                 2925             


Arg Ala  Ala Gln Ser Glu Arg  Leu Leu Thr His Pro  Lys Asp Val 
    2930                 2935                 2940             


Asp Gly  Asn Asp Leu Leu Ser  Tyr Trp Pro Ala Leu  Gly Glu Cys 
    2945                 2950                 2955             


Glu Ala  Ala Pro Cys Ala Leu  Gln Thr Trp Gly Ser  Glu Arg Arg 
    2960                 2965                 2970             


Leu Gly  Leu Asp Thr Ser Lys  Asp Ala Ala Asn Asn  Asn Gln Pro 
    2975                 2980                 2985             


Asp Pro  Ala Leu Thr Ser Gly  Asp Glu Thr Ser Leu  Gly Arg Ala 
    2990                 2995                 3000             


Gln Arg  Gln Arg Lys Gly Ile  Leu Lys Asn Arg Leu  Gln Tyr Pro 
    3005                 3010                 3015             


Leu Val  Pro Gln Thr Arg Gly  Ala Pro Glu Leu Ser  Trp Cys Arg 
    3020                 3025                 3030             


Ala Ala  Thr Leu Gly His Arg  Ala Val Pro Ala Ala  Ser Tyr Gly 
    3035                 3040                 3045             


Arg Ile  Tyr Ala Gly Gly Gly  Thr Gly Ser Leu Ser  Gln Pro Ala 
    3050                 3055                 3060             


Ser Arg  Tyr Ser Ser Arg Glu  Gln Leu Asp Leu Leu  Leu Arg Arg 
    3065                 3070                 3075             


Gln Leu  Ser Arg Glu Arg Leu  Glu Glu Ala Pro Ala  Pro Val Leu 
    3080                 3085                 3090             


Arg Pro  Leu Ser Arg Pro Gly  Ser Gln Glu Cys Met  Asp Ala Ala 
    3095                 3100                 3105             


Pro Gly  Arg Leu Glu Pro Lys  Asp Arg Gly Ser Thr  Leu Pro Arg 
    3110                 3115                 3120             


Arg Gln  Pro Pro Arg Asp Tyr  Pro Gly Ala Met Ala  Gly Arg Phe 
    3125                 3130                 3135             


Gly Ser  Arg Asp Ala Leu Asp  Leu Gly Ala Pro Arg  Glu Trp Leu 
    3140                 3145                 3150             


Ser Thr  Leu Pro Pro Pro Arg  Arg Thr Arg Asp Leu  Asp Pro Gln 
    3155                 3160                 3165             


Pro Pro  Pro Leu Pro Leu Ser  Pro Gln Arg Gln Leu  Ser Arg Asp 
    3170                 3175                 3180             


Pro Leu  Leu Pro Ser Arg Pro  Leu Asp Ser Leu Ser  Arg Ser Ser 
    3185                 3190                 3195             


Asn Ser  Arg Glu Gln Leu Asp  Gln Val Pro Ser Arg  His Pro Ser 
    3200                 3205                 3210             


Arg Glu  Ala Leu Gly Pro Leu  Pro Gln Leu Leu Arg  Ala Arg Glu 
    3215                 3220                 3225             


Asp Ser  Val Ser Gly Pro Ser  His Gly Pro Ser Thr  Glu Gln Leu 
    3230                 3235                 3240             


Asp Ile  Leu Ser Ser Ile Leu  Ala Ser Phe Asn Ser  Ser Ala Leu 
    3245                 3250                 3255             


Ser Ser  Val Gln Ser Ser Ser  Thr Pro Leu Gly Pro  His Thr Thr 
    3260                 3265                 3270             


Ala Thr  Pro Ser Ala Thr Ala  Ser Val Leu Gly Pro  Ser Thr Pro 
    3275                 3280                 3285             


Arg Ser  Ala Thr Ser His Ser  Ile Ser Glu Leu Ser  Pro Asp Ser 
    3290                 3295                 3300             


Glu Val  Pro Arg Ser Glu Gly  His Ser 
    3305                 3310         


<210>  2365
<211>  2923
<212>  PRT
<213>  Homo sapiens

<400>  2365

Met Arg Ser Pro Ala Thr Gly Val Pro Leu Pro Thr Pro Pro Pro Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro Pro Pro Leu Leu Gly Asp 
            20                  25                  30          


Gln Val Gly Pro Cys Arg Ser Leu Gly Ser Arg Gly Arg Gly Ser Ser 
        35                  40                  45              


Gly Ala Cys Ala Pro Met Gly Trp Leu Cys Pro Ser Ser Ala Ser Asn 
    50                  55                  60                  


Leu Trp Leu Tyr Thr Ser Arg Cys Arg Asp Ala Gly Thr Glu Leu Thr 
65                  70                  75                  80  


Gly His Leu Val Pro His His Asp Gly Leu Arg Val Trp Cys Pro Glu 
                85                  90                  95      


Ser Glu Ala His Ile Pro Leu Pro Pro Ala Pro Glu Gly Cys Pro Trp 
            100                 105                 110         


Ser Cys Arg Leu Leu Gly Ile Gly Gly His Leu Ser Pro Gln Gly Lys 
        115                 120                 125             


Leu Thr Leu Pro Glu Glu His Pro Cys Leu Lys Ala Pro Arg Leu Arg 
    130                 135                 140                 


Cys Gln Ser Cys Lys Leu Ala Gln Ala Pro Gly Leu Arg Ala Gly Glu 
145                 150                 155                 160 


Arg Ser Pro Glu Glu Ser Leu Gly Gly Arg Arg Lys Arg Asn Val Asn 
                165                 170                 175     


Thr Ala Pro Gln Phe Gln Pro Pro Ser Tyr Gln Ala Thr Val Pro Glu 
            180                 185                 190         


Asn Gln Pro Ala Gly Thr Pro Val Ala Ser Leu Arg Ala Ile Asp Pro 
        195                 200                 205             


Asp Glu Gly Glu Ala Gly Arg Leu Glu Tyr Thr Met Asp Ala Leu Phe 
    210                 215                 220                 


Asp Ser Arg Ser Asn Gln Phe Phe Ser Leu Asp Pro Val Thr Gly Ala 
225                 230                 235                 240 


Val Thr Thr Ala Glu Glu Leu Asp Arg Glu Thr Lys Ser Thr His Val 
                245                 250                 255     


Phe Arg Val Thr Ala Gln Asp His Gly Met Pro Arg Arg Ser Ala Leu 
            260                 265                 270         


Ala Thr Leu Thr Ile Leu Val Thr Asp Thr Asn Asp His Asp Pro Val 
        275                 280                 285             


Phe Glu Gln Gln Glu Tyr Lys Glu Ser Leu Arg Glu Asn Leu Glu Val 
    290                 295                 300                 


Gly Tyr Glu Val Leu Thr Val Arg Ala Thr Asp Gly Asp Ala Pro Pro 
305                 310                 315                 320 


Asn Ala Asn Ile Leu Tyr Arg Leu Leu Glu Gly Ser Gly Gly Ser Pro 
                325                 330                 335     


Ser Glu Val Phe Glu Ile Asp Pro Arg Ser Gly Val Ile Arg Thr Arg 
            340                 345                 350         


Gly Pro Val Asp Arg Glu Glu Val Glu Ser Tyr Gln Leu Thr Val Glu 
        355                 360                 365             


Ala Ser Asp Gln Gly Arg Asp Pro Gly Pro Arg Ser Thr Thr Ala Ala 
    370                 375                 380                 


Val Phe Leu Ser Val Glu Asp Asp Asn Asp Asn Ala Pro Gln Phe Ser 
385                 390                 395                 400 


Glu Lys Arg Tyr Val Val Gln Val Arg Glu Asp Val Thr Pro Gly Ala 
                405                 410                 415     


Pro Val Leu Arg Val Thr Ala Ser Asp Arg Asp Lys Gly Ser Asn Ala 
            420                 425                 430         


Val Val His Tyr Ser Ile Met Ser Gly Asn Ala Arg Gly Gln Phe Tyr 
        435                 440                 445             


Leu Asp Ala Gln Thr Gly Ala Leu Asp Val Val Ser Pro Leu Asp Tyr 
    450                 455                 460                 


Glu Thr Thr Lys Glu Tyr Thr Leu Arg Val Arg Ala Gln Asp Gly Gly 
465                 470                 475                 480 


Arg Pro Pro Leu Ser Asn Val Ser Gly Leu Val Thr Val Gln Val Leu 
                485                 490                 495     


Asp Ile Asn Asp Asn Ala Pro Ile Phe Val Ser Thr Pro Phe Gln Ala 
            500                 505                 510         


Thr Val Leu Glu Ser Val Pro Leu Gly Tyr Leu Val Leu His Val Gln 
        515                 520                 525             


Ala Ile Asp Ala Asp Ala Gly Asp Asn Ala Arg Leu Glu Tyr Arg Leu 
    530                 535                 540                 


Ala Gly Val Gly His Asp Phe Pro Phe Thr Ile Asn Asn Gly Thr Gly 
545                 550                 555                 560 


Trp Ile Ser Val Ala Ala Glu Leu Asp Arg Glu Glu Val Asp Phe Tyr 
                565                 570                 575     


Ser Phe Gly Val Glu Ala Arg Asp His Gly Thr Pro Ala Leu Thr Ala 
            580                 585                 590         


Ser Ala Ser Val Ser Val Thr Val Leu Asp Val Asn Asp Asn Asn Pro 
        595                 600                 605             


Thr Phe Thr Gln Pro Glu Tyr Thr Val Arg Leu Asn Glu Asp Ala Ala 
    610                 615                 620                 


Val Gly Thr Ser Val Val Thr Val Ser Ala Val Asp Arg Asp Ala His 
625                 630                 635                 640 


Ser Val Ile Thr Tyr Gln Ile Thr Ser Gly Asn Thr Arg Asn Arg Phe 
                645                 650                 655     


Ser Ile Thr Ser Gln Ser Gly Gly Gly Leu Val Ser Leu Ala Leu Pro 
            660                 665                 670         


Leu Asp Tyr Lys Leu Glu Arg Gln Tyr Val Leu Ala Val Thr Ala Ser 
        675                 680                 685             


Asp Gly Thr Arg Gln Asp Thr Ala Gln Ile Val Val Asn Val Thr Asp 
    690                 695                 700                 


Ala Asn Thr His Arg Pro Val Phe Gln Ser Ser His Tyr Thr Val Asn 
705                 710                 715                 720 


Val Asn Glu Asp Arg Pro Ala Gly Thr Thr Val Val Leu Ile Ser Ala 
                725                 730                 735     


Thr Asp Glu Asp Thr Gly Glu Asn Ala Arg Ile Thr Tyr Phe Met Glu 
            740                 745                 750         


Asp Ser Ile Pro Gln Phe Arg Ile Asp Ala Asp Thr Gly Ala Val Thr 
        755                 760                 765             


Thr Gln Ala Glu Leu Asp Tyr Glu Asp Gln Val Ser Tyr Thr Leu Ala 
    770                 775                 780                 


Ile Thr Ala Arg Asp Asn Gly Ile Pro Gln Lys Ser Asp Thr Thr Tyr 
785                 790                 795                 800 


Leu Glu Ile Leu Val Asn Asp Val Asn Asp Asn Ala Pro Gln Phe Leu 
                805                 810                 815     


Arg Asp Ser Tyr Gln Gly Ser Val Tyr Glu Asp Val Pro Pro Phe Thr 
            820                 825                 830         


Ser Val Leu Gln Ile Ser Ala Thr Asp Arg Asp Ser Gly Leu Asn Gly 
        835                 840                 845             


Arg Val Phe Tyr Thr Phe Gln Gly Gly Asp Asp Gly Asp Gly Asp Phe 
    850                 855                 860                 


Ile Val Glu Ser Thr Ser Gly Ile Val Arg Thr Leu Arg Arg Leu Asp 
865                 870                 875                 880 


Arg Glu Asn Val Ala Gln Tyr Val Leu Arg Ala Tyr Ala Val Asp Lys 
                885                 890                 895     


Gly Met Pro Pro Ala Arg Thr Pro Met Glu Val Thr Val Thr Val Leu 
            900                 905                 910         


Asp Val Asn Asp Asn Pro Pro Val Phe Glu Gln Asp Glu Phe Asp Val 
        915                 920                 925             


Phe Val Glu Glu Asn Ser Pro Ile Gly Leu Ala Val Ala Arg Val Thr 
    930                 935                 940                 


Ala Thr Asp Pro Asp Glu Gly Thr Asn Ala Gln Ile Met Tyr Gln Ile 
945                 950                 955                 960 


Val Glu Gly Asn Ile Pro Glu Val Phe Gln Leu Asp Ile Phe Ser Gly 
                965                 970                 975     


Glu Leu Thr Ala Leu Val Asp Leu Asp Tyr Glu Asp Arg Pro Glu Tyr 
            980                 985                 990         


Val Leu Val Ile Gln Ala Thr Ser  Ala Pro Leu Val Ser  Arg Ala Thr 
        995                 1000                 1005             


Val His  Val Arg Leu Leu Asp  Arg Asn Asp Asn Pro  Pro Val Leu 
    1010                 1015                 1020             


Gly Asn  Phe Glu Ile Leu Phe  Asn Asn Tyr Val Thr  Asn Arg Ser 
    1025                 1030                 1035             


Ser Ser  Phe Pro Gly Gly Ala  Ile Gly Arg Val Pro  Ala His Asp 
    1040                 1045                 1050             


Pro Asp  Ile Ser Asp Ser Leu  Thr Tyr Ser Phe Glu  Arg Gly Asn 
    1055                 1060                 1065             


Glu Leu  Ser Leu Val Leu Leu  Asn Ala Ser Thr Gly  Glu Leu Lys 
    1070                 1075                 1080             


Leu Ser  Arg Ala Leu Asp Asn  Asn Arg Pro Leu Glu  Ala Ile Met 
    1085                 1090                 1095             


Ser Val  Leu Val Ser Asp Gly  Val His Ser Val Thr  Ala Gln Cys 
    1100                 1105                 1110             


Ala Leu  Arg Val Thr Ile Ile  Thr Asp Glu Met Leu  Thr His Ser 
    1115                 1120                 1125             


Ile Thr  Leu Arg Leu Glu Asp  Met Ser Pro Glu Arg  Phe Leu Ser 
    1130                 1135                 1140             


Pro Leu  Leu Gly Leu Phe Ile  Gln Ala Val Ala Ala  Thr Leu Ala 
    1145                 1150                 1155             


Thr Pro  Pro Asp His Val Val  Val Phe Asn Val Gln  Arg Asp Thr 
    1160                 1165                 1170             


Asp Ala  Pro Gly Gly His Ile  Leu Asn Val Ser Leu  Ser Val Gly 
    1175                 1180                 1185             


Gln Pro  Pro Gly Pro Gly Gly  Gly Pro Pro Phe Leu  Pro Ser Glu 
    1190                 1195                 1200             


Asp Leu  Gln Glu Arg Leu Tyr  Leu Asn Arg Ser Leu  Leu Thr Ala 
    1205                 1210                 1215             


Ile Ser  Ala Gln Arg Val Leu  Pro Phe Asp Asp Asn  Ile Cys Leu 
    1220                 1225                 1230             


Arg Glu  Pro Cys Glu Asn Tyr  Met Arg Cys Val Ser  Val Leu Arg 
    1235                 1240                 1245             


Phe Asp  Ser Ser Ala Pro Phe  Ile Ala Ser Ser Ser  Val Leu Phe 
    1250                 1255                 1260             


Arg Pro  Ile His Pro Val Gly  Gly Leu Arg Cys Arg  Cys Pro Pro 
    1265                 1270                 1275             


Gly Phe  Thr Gly Asp Tyr Cys  Glu Thr Glu Val Asp  Leu Cys Tyr 
    1280                 1285                 1290             


Ser Arg  Pro Cys Gly Pro His  Gly Arg Cys Arg Ser  Arg Glu Gly 
    1295                 1300                 1305             


Gly Tyr  Thr Cys Leu Cys Arg  Asp Gly Tyr Thr Gly  Glu His Cys 
    1310                 1315                 1320             


Glu Val  Ser Ala Arg Ser Gly  Arg Cys Thr Pro Gly  Val Cys Lys 
    1325                 1330                 1335             


Asn Gly  Gly Thr Cys Val Asn  Leu Leu Val Gly Gly  Phe Lys Cys 
    1340                 1345                 1350             


Asp Cys  Pro Ser Gly Asp Phe  Glu Lys Pro Tyr Cys  Gln Val Thr 
    1355                 1360                 1365             


Thr Arg  Ser Phe Pro Ala His  Ser Phe Ile Thr Phe  Arg Gly Leu 
    1370                 1375                 1380             


Arg Gln  Arg Phe His Phe Thr  Leu Ala Leu Ser Phe  Ala Thr Lys 
    1385                 1390                 1395             


Glu Arg  Asp Gly Leu Leu Leu  Tyr Asn Gly Arg Phe  Asn Glu Lys 
    1400                 1405                 1410             


His Asp  Phe Val Ala Leu Glu  Val Ile Gln Glu Gln  Val Gln Leu 
    1415                 1420                 1425             


Thr Phe  Ser Ala Gly Glu Ser  Thr Thr Thr Val Ser  Pro Phe Val 
    1430                 1435                 1440             


Pro Gly  Gly Val Ser Asp Gly  Gln Trp His Thr Val  Gln Leu Lys 
    1445                 1450                 1455             


Tyr Tyr  Asn Lys Pro Leu Leu  Gly Gln Thr Gly Leu  Pro Gln Gly 
    1460                 1465                 1470             


Pro Ser  Glu Gln Lys Val Ala  Val Val Thr Val Asp  Gly Cys Asp 
    1475                 1480                 1485             


Thr Gly  Val Ala Leu Arg Phe  Gly Ser Val Leu Gly  Asn Tyr Ser 
    1490                 1495                 1500             


Cys Ala  Ala Gln Gly Thr Gln  Gly Gly Ser Lys Lys  Ser Leu Asp 
    1505                 1510                 1515             


Leu Thr  Gly Pro Leu Leu Leu  Gly Gly Val Pro Asp  Leu Pro Glu 
    1520                 1525                 1530             


Ser Phe  Pro Val Arg Met Arg  Gln Phe Val Gly Cys  Met Arg Asn 
    1535                 1540                 1545             


Leu Gln  Val Asp Ser Arg His  Ile Asp Met Ala Asp  Phe Ile Ala 
    1550                 1555                 1560             


Asn Asn  Gly Thr Val Pro Gly  Cys Pro Ala Lys Lys  Asn Val Cys 
    1565                 1570                 1575             


Asp Ser  Asn Thr Cys His Asn  Gly Gly Thr Cys Val  Asn Gln Trp 
    1580                 1585                 1590             


Asp Ala  Phe Ser Cys Glu Cys  Pro Leu Gly Phe Gly  Gly Lys Ser 
    1595                 1600                 1605             


Cys Ala  Gln Glu Met Ala Asn  Pro Gln His Phe Leu  Gly Ser Ser 
    1610                 1615                 1620             


Leu Val  Ala Trp His Gly Leu  Ser Leu Pro Ile Ser  Gln Pro Trp 
    1625                 1630                 1635             


Tyr Leu  Ser Leu Met Phe Arg  Thr Arg Gln Ala Asp  Gly Val Leu 
    1640                 1645                 1650             


Leu Gln  Ala Ile Thr Arg Gly  Arg Ser Thr Ile Thr  Leu Gln Leu 
    1655                 1660                 1665             


Arg Glu  Gly His Val Met Leu  Ser Val Glu Gly Thr  Gly Leu Gln 
    1670                 1675                 1680             


Ala Ser  Ser Leu Arg Leu Glu  Pro Gly Arg Ala Asn  Asp Gly Asp 
    1685                 1690                 1695             


Trp His  His Ala Gln Leu Ala  Leu Gly Ala Ser Gly  Gly Pro Gly 
    1700                 1705                 1710             


His Ala  Ile Leu Ser Phe Asp  Tyr Gly Gln Gln Arg  Ala Glu Gly 
    1715                 1720                 1725             


Asn Leu  Gly Pro Arg Leu His  Gly Leu His Leu Ser  Asn Ile Thr 
    1730                 1735                 1740             


Val Gly  Gly Ile Pro Gly Pro  Ala Gly Gly Val Ala  Arg Gly Phe 
    1745                 1750                 1755             


Arg Gly  Cys Leu Gln Gly Val  Arg Val Ser Asp Thr  Pro Glu Gly 
    1760                 1765                 1770             


Val Asn  Ser Leu Asp Pro Ser  His Gly Glu Ser Ile  Asn Val Glu 
    1775                 1780                 1785             


Gln Gly  Cys Ser Leu Pro Asp  Pro Cys Asp Ser Asn  Pro Cys Pro 
    1790                 1795                 1800             


Ala Asn  Ser Tyr Cys Ser Asn  Asp Trp Asp Ser Tyr  Ser Cys Ser 
    1805                 1810                 1815             


Cys Asp  Pro Gly Tyr Tyr Gly  Asp Asn Cys Thr Asn  Val Cys Asp 
    1820                 1825                 1830             


Leu Asn  Pro Cys Glu His Gln  Ser Val Cys Thr Arg  Lys Pro Ser 
    1835                 1840                 1845             


Ala Pro  His Gly Tyr Thr Cys  Glu Cys Pro Pro Asn  Tyr Leu Gly 
    1850                 1855                 1860             


Pro Tyr  Cys Glu Thr Arg Ile  Asp Gln Pro Cys Pro  Arg Gly Trp 
    1865                 1870                 1875             


Trp Gly  His Pro Thr Cys Gly  Pro Cys Asn Cys Asp  Val Ser Lys 
    1880                 1885                 1890             


Gly Phe  Asp Pro Asp Cys Asn  Lys Thr Ser Gly Glu  Cys His Cys 
    1895                 1900                 1905             


Lys Glu  Asn His Tyr Arg Pro  Pro Gly Ser Pro Thr  Cys Leu Leu 
    1910                 1915                 1920             


Cys Asp  Cys Tyr Pro Thr Gly  Ser Leu Ser Arg Val  Cys Asp Pro 
    1925                 1930                 1935             


Glu Asp  Gly Gln Cys Pro Cys  Lys Pro Gly Val Ile  Gly Arg Gln 
    1940                 1945                 1950             


Cys Asp  Arg Cys Asp Asn Pro  Phe Ala Glu Val Thr  Thr Asn Gly 
    1955                 1960                 1965             


Cys Glu  Val Asn Tyr Asp Ser  Cys Pro Arg Ala Ile  Glu Ala Gly 
    1970                 1975                 1980             


Ile Trp  Trp Pro Arg Thr Arg  Phe Gly Leu Pro Ala  Ala Ala Pro 
    1985                 1990                 1995             


Cys Pro  Lys Gly Ser Phe Gly  Thr Ala Val Arg His  Cys Asp Glu 
    2000                 2005                 2010             


His Arg  Gly Trp Leu Pro Pro  Asn Leu Phe Asn Cys  Thr Ser Ile 
    2015                 2020                 2025             


Thr Phe  Ser Glu Leu Lys Gly  Phe Ala Glu Arg Leu  Gln Arg Asn 
    2030                 2035                 2040             


Glu Ser  Gly Leu Asp Ser Gly  Arg Ser Gln Gln Leu  Ala Leu Leu 
    2045                 2050                 2055             


Leu Arg  Asn Ala Thr Gln His  Thr Ala Gly Tyr Phe  Gly Ser Asp 
    2060                 2065                 2070             


Val Lys  Val Ala Tyr Gln Leu  Ala Thr Arg Leu Leu  Ala His Glu 
    2075                 2080                 2085             


Ser Thr  Gln Arg Gly Phe Gly  Leu Ser Ala Thr Gln  Asp Val His 
    2090                 2095                 2100             


Phe Thr  Glu Asn Leu Leu Arg  Val Gly Ser Ala Leu  Leu Asp Thr 
    2105                 2110                 2115             


Ala Asn  Lys Arg His Trp Glu  Leu Ile Gln Gln Thr  Glu Gly Gly 
    2120                 2125                 2130             


Thr Ala  Trp Leu Leu Gln His  Tyr Glu Ala Tyr Ala  Ser Ala Leu 
    2135                 2140                 2145             


Ala Gln  Asn Met Arg His Thr  Tyr Leu Ser Pro Phe  Thr Ile Val 
    2150                 2155                 2160             


Thr Pro  Asn Ile Val Ile Ser  Val Val Arg Leu Asp  Lys Gly Asn 
    2165                 2170                 2175             


Phe Ala  Gly Ala Lys Leu Pro  Arg Tyr Glu Ala Leu  Arg Gly Glu 
    2180                 2185                 2190             


Gln Pro  Pro Asp Leu Glu Thr  Thr Val Ile Leu Pro  Glu Ser Val 
    2195                 2200                 2205             


Phe Arg  Glu Thr Pro Pro Val  Val Arg Pro Ala Gly  Pro Gly Glu 
    2210                 2215                 2220             


Ala Gln  Glu Pro Glu Glu Leu  Ala Arg Arg Gln Arg  Arg His Pro 
    2225                 2230                 2235             


Glu Leu  Ser Gln Gly Glu Ala  Val Ala Ser Val Ile  Ile Tyr Arg 
    2240                 2245                 2250             


Thr Leu  Ala Gly Leu Leu Pro  His Asn Tyr Asp Pro  Asp Lys Arg 
    2255                 2260                 2265             


Ser Leu  Arg Val Pro Lys Arg  Pro Ile Ile Asn Thr  Pro Val Val 
    2270                 2275                 2280             


Ser Ile  Ser Val His Asp Asp  Glu Glu Leu Leu Pro  Arg Ala Leu 
    2285                 2290                 2295             


Asp Lys  Pro Val Thr Val Gln  Phe Arg Leu Leu Glu  Thr Glu Glu 
    2300                 2305                 2310             


Arg Thr  Lys Pro Ile Cys Val  Phe Trp Asn His Ser  Ile Leu Val 
    2315                 2320                 2325             


Ser Gly  Thr Gly Gly Trp Ser  Ala Arg Gly Cys Glu  Val Val Phe 
    2330                 2335                 2340             


Arg Asn  Glu Ser His Val Ser  Cys Gln Cys Asn His  Met Thr Ser 
    2345                 2350                 2355             


Phe Ala  Val Leu Met Asp Val  Ser Arg Arg Glu Asn  Gly Glu Ile 
    2360                 2365                 2370             


Leu Pro  Leu Lys Thr Leu Thr  Tyr Val Ala Leu Gly  Val Thr Leu 
    2375                 2380                 2385             


Ala Ala  Leu Leu Leu Thr Phe  Phe Phe Leu Thr Leu  Leu Arg Ile 
    2390                 2395                 2400             


Leu Arg  Ser Asn Gln His Gly  Ile Arg Arg Asn Leu  Thr Ala Ala 
    2405                 2410                 2415             


Leu Gly  Leu Ala Gln Leu Val  Phe Leu Leu Gly Ile  Asn Gln Ala 
    2420                 2425                 2430             


Asp Leu  Pro Phe Ala Cys Thr  Val Ile Ala Ile Leu  Leu His Phe 
    2435                 2440                 2445             


Leu Tyr  Leu Cys Thr Phe Ser  Trp Ala Leu Leu Glu  Ala Leu His 
    2450                 2455                 2460             


Leu Tyr  Arg Ala Leu Thr Glu  Val Arg Asp Val Asn  Thr Gly Pro 
    2465                 2470                 2475             


Met Arg  Phe Tyr Tyr Met Leu  Gly Trp Gly Val Pro  Ala Phe Ile 
    2480                 2485                 2490             


Thr Gly  Leu Ala Val Gly Leu  Asp Pro Glu Gly Tyr  Gly Asn Pro 
    2495                 2500                 2505             


Asp Phe  Cys Trp Leu Ser Ile  Tyr Asp Thr Leu Ile  Trp Ser Phe 
    2510                 2515                 2520             


Ala Gly  Pro Val Ala Phe Ala  Val Ser Met Ser Val  Phe Leu Tyr 
    2525                 2530                 2535             


Ile Leu  Ala Ala Arg Ala Ser  Cys Ala Ala Gln Arg  Gln Gly Phe 
    2540                 2545                 2550             


Glu Lys  Lys Gly Pro Val Ser  Gly Leu Gln Pro Ser  Phe Ala Val 
    2555                 2560                 2565             


Leu Leu  Leu Leu Ser Ala Thr  Trp Leu Leu Ala Leu  Leu Ser Val 
    2570                 2575                 2580             


Asn Ser  Asp Thr Leu Leu Phe  His Tyr Leu Phe Ala  Thr Cys Asn 
    2585                 2590                 2595             


Cys Ile  Gln Gly Pro Phe Ile  Phe Leu Ser Tyr Val  Val Leu Ser 
    2600                 2605                 2610             


Lys Glu  Val Arg Lys Ala Leu  Lys Leu Ala Cys Ser  Arg Lys Pro 
    2615                 2620                 2625             


Ser Pro  Asp Pro Ala Leu Thr  Thr Lys Ser Thr Leu  Thr Ser Ser 
    2630                 2635                 2640             


Tyr Asn  Cys Pro Ser Pro Tyr  Ala Asp Gly Arg Leu  Tyr Gln Pro 
    2645                 2650                 2655             


Tyr Gly  Asp Ser Ala Gly Ser  Leu His Ser Thr Ser  Arg Ser Gly 
    2660                 2665                 2670             


Lys Ser  Gln Pro Ser Tyr Ile  Pro Phe Leu Leu Arg  Glu Glu Ser 
    2675                 2680                 2685             


Ala Leu  Asn Pro Gly Gln Gly  Pro Pro Gly Leu Gly  Asp Pro Gly 
    2690                 2695                 2700             


Ser Leu  Phe Leu Glu Gly Gln  Asp Gln Gln His Asp  Pro Asp Thr 
    2705                 2710                 2715             


Asp Ser  Asp Ser Asp Leu Ser  Leu Glu Asp Asp Gln  Ser Gly Ser 
    2720                 2725                 2730             


Tyr Ala  Ser Thr His Ser Ser  Asp Ser Glu Glu Glu  Glu Glu Glu 
    2735                 2740                 2745             


Glu Glu  Glu Glu Ala Ala Phe  Pro Gly Glu Gln Gly  Trp Asp Ser 
    2750                 2755                 2760             


Leu Leu  Gly Pro Gly Ala Glu  Arg Leu Pro Leu His  Ser Thr Pro 
    2765                 2770                 2775             


Lys Asp  Gly Gly Pro Gly Pro  Gly Lys Ala Pro Trp  Pro Gly Asp 
    2780                 2785                 2790             


Phe Gly  Thr Thr Ala Lys Glu  Ser Ser Gly Asn Gly  Ala Pro Glu 
    2795                 2800                 2805             


Glu Arg  Leu Arg Glu Asn Gly  Asp Ala Leu Ser Arg  Glu Gly Ser 
    2810                 2815                 2820             


Leu Gly  Pro Leu Pro Gly Ser  Ser Ala Gln Pro His  Lys Gly Ile 
    2825                 2830                 2835             


Leu Lys  Lys Lys Cys Leu Pro  Thr Ile Ser Glu Lys  Ser Ser Leu 
    2840                 2845                 2850             


Leu Arg  Leu Pro Leu Glu Gln  Cys Thr Gly Ser Ser  Arg Gly Ser 
    2855                 2860                 2865             


Ser Ala  Ser Glu Gly Ser Arg  Gly Gly Pro Pro Pro  Arg Pro Pro 
    2870                 2875                 2880             


Pro Arg  Gln Ser Leu Gln Glu  Gln Leu Asn Gly Val  Met Pro Ile 
    2885                 2890                 2895             


Ala Met  Ser Ile Lys Ala Gly  Thr Val Asp Glu Asp  Ser Ser Gly 
    2900                 2905                 2910             


Ser Glu  Phe Leu Phe Phe Asn  Phe Leu His 
    2915                 2920             


<210>  2366
<211>  1541
<212>  PRT
<213>  Homo sapiens

<400>  2366

Met Ser Phe Leu Glu Glu Ala Arg Ala Ala Gly Arg Ala Val Val Leu 
1               5                   10                  15      


Ala Leu Val Leu Leu Leu Leu Pro Ala Val Pro Val Gly Ala Ser Val 
            20                  25                  30          


Pro Pro Arg Pro Leu Leu Pro Leu Gln Pro Gly Met Pro His Val Cys 
        35                  40                  45              


Ala Glu Gln Glu Leu Thr Leu Val Gly Arg Arg Gln Pro Cys Val Gln 
    50                  55                  60                  


Ala Leu Ser His Thr Val Pro Val Trp Lys Ala Gly Cys Gly Trp Gln 
65                  70                  75                  80  


Ala Trp Cys Val Gly His Glu Arg Arg Thr Val Tyr Tyr Met Gly Tyr 
                85                  90                  95      


Arg Gln Val Tyr Thr Thr Glu Ala Arg Thr Val Leu Arg Cys Cys Arg 
            100                 105                 110         


Gly Trp Met Gln Gln Pro Asp Glu Glu Gly Cys Leu Ser Ala Glu Cys 
        115                 120                 125             


Ser Ala Ser Leu Cys Phe His Gly Gly Arg Cys Val Pro Gly Ser Ala 
    130                 135                 140                 


Gln Pro Cys His Cys Pro Pro Gly Phe Gln Gly Pro Arg Cys Gln Tyr 
145                 150                 155                 160 


Asp Val Asp Glu Cys Arg Thr His Asn Gly Gly Cys Gln His Arg Cys 
                165                 170                 175     


Val Asn Thr Pro Gly Ser Tyr Leu Cys Glu Cys Lys Pro Gly Phe Arg 
            180                 185                 190         


Leu His Thr Asp Ser Arg Thr Cys Leu Ala Ile Asn Ser Cys Ala Leu 
        195                 200                 205             


Gly Asn Gly Gly Cys Gln His His Cys Val Gln Leu Thr Ile Thr Arg 
    210                 215                 220                 


His Arg Cys Gln Cys Arg Pro Gly Phe Gln Leu Gln Glu Asp Gly Arg 
225                 230                 235                 240 


His Cys Val Arg Arg Ser Pro Cys Ala Asn Arg Asn Gly Ser Cys Met 
                245                 250                 255     


His Arg Cys Gln Val Val Arg Gly Leu Ala Arg Cys Glu Cys His Val 
            260                 265                 270         


Gly Tyr Gln Leu Ala Ala Asp Gly Lys Ala Cys Glu Asp Val Asp Glu 
        275                 280                 285             


Cys Ala Ala Gly Leu Ala Gln Cys Ala His Gly Cys Leu Asn Thr Gln 
    290                 295                 300                 


Gly Ser Phe Lys Cys Val Cys His Ala Gly Tyr Glu Leu Gly Ala Asp 
305                 310                 315                 320 


Gly Arg Gln Cys Tyr Arg Ile Glu Met Glu Ile Val Asn Ser Cys Glu 
                325                 330                 335     


Ala Asn Asn Gly Gly Cys Ser His Gly Cys Ser His Thr Ser Ala Gly 
            340                 345                 350         


Pro Leu Cys Thr Cys Pro Arg Gly Tyr Glu Leu Asp Thr Asp Gln Arg 
        355                 360                 365             


Thr Cys Ile Asp Val Asp Asp Cys Ala Asp Ser Pro Cys Cys Gln Gln 
    370                 375                 380                 


Val Cys Thr Asn Asn Pro Gly Gly Tyr Glu Cys Gly Cys Tyr Ala Gly 
385                 390                 395                 400 


Tyr Arg Leu Ser Ala Asp Gly Cys Gly Cys Glu Asp Val Asp Glu Cys 
                405                 410                 415     


Ala Ser Ser Arg Gly Gly Cys Glu His His Cys Thr Asn Leu Ala Gly 
            420                 425                 430         


Ser Phe Gln Cys Ser Cys Glu Ala Gly Tyr Arg Leu His Glu Asp Arg 
        435                 440                 445             


Arg Gly Cys Ser Pro Leu Glu Glu Pro Met Val Asp Leu Asp Gly Glu 
    450                 455                 460                 


Leu Pro Phe Val Arg Pro Leu Pro His Ile Ala Val Leu Gln Asp Glu 
465                 470                 475                 480 


Leu Pro Gln Leu Phe Gln Asp Asp Asp Val Gly Ala Asp Glu Glu Glu 
                485                 490                 495     


Ala Glu Leu Arg Gly Glu His Thr Leu Thr Glu Lys Phe Val Cys Leu 
            500                 505                 510         


Asp Asp Ser Phe Gly His Asp Cys Ser Leu Thr Cys Asp Asp Cys Arg 
        515                 520                 525             


Asn Gly Gly Thr Cys Leu Leu Gly Leu Asp Gly Cys Asp Cys Pro Glu 
    530                 535                 540                 


Gly Trp Thr Gly Leu Ile Cys Asn Glu Thr Cys Pro Pro Asp Thr Phe 
545                 550                 555                 560 


Gly Lys Asn Cys Ser Phe Ser Cys Ser Cys Gln Asn Gly Gly Thr Cys 
                565                 570                 575     


Asp Ser Val Thr Gly Ala Cys Arg Cys Pro Pro Gly Val Ser Gly Thr 
            580                 585                 590         


Asn Cys Glu Asp Gly Cys Pro Lys Gly Tyr Tyr Gly Lys His Cys Arg 
        595                 600                 605             


Lys Lys Cys Asn Cys Ala Asn Arg Gly Arg Cys His Arg Leu Tyr Gly 
    610                 615                 620                 


Ala Cys Leu Cys Asp Pro Gly Leu Tyr Gly Arg Phe Cys His Leu Thr 
625                 630                 635                 640 


Cys Pro Pro Trp Ala Phe Gly Pro Gly Cys Ser Glu Glu Cys Gln Cys 
                645                 650                 655     


Val Gln Pro His Thr Gln Ser Cys Asp Lys Arg Asp Gly Ser Cys Ser 
            660                 665                 670         


Cys Lys Ala Gly Phe Arg Gly Glu Arg Cys Gln Ala Glu Cys Glu Leu 
        675                 680                 685             


Gly Tyr Phe Gly Pro Gly Cys Trp Gln Ala Cys Thr Cys Pro Val Gly 
    690                 695                 700                 


Val Ala Cys Asp Ser Val Ser Gly Glu Cys Gly Lys Arg Cys Pro Ala 
705                 710                 715                 720 


Gly Phe Gln Gly Glu Asp Cys Gly Gln Glu Cys Pro Val Gly Thr Phe 
                725                 730                 735     


Gly Val Asn Cys Ser Ser Ser Cys Ser Cys Gly Gly Ala Pro Cys His 
            740                 745                 750         


Gly Val Thr Gly Gln Cys Arg Cys Pro Pro Gly Arg Thr Gly Glu Asp 
        755                 760                 765             


Cys Glu Ala Asp Cys Pro Glu Gly Arg Trp Gly Leu Gly Cys Gln Glu 
    770                 775                 780                 


Ile Cys Pro Ala Cys Gln His Ala Ala Arg Cys Asp Pro Glu Thr Gly 
785                 790                 795                 800 


Ala Cys Leu Cys Leu Pro Gly Phe Val Gly Ser Arg Cys Gln Asp Val 
                805                 810                 815     


Cys Pro Ala Gly Trp Tyr Gly Pro Ser Cys Gln Thr Arg Cys Ser Cys 
            820                 825                 830         


Ala Asn Asp Gly His Cys His Pro Ala Thr Gly His Cys Ser Cys Ala 
        835                 840                 845             


Pro Gly Trp Thr Gly Phe Ser Cys Gln Arg Ala Cys Asp Thr Gly His 
    850                 855                 860                 


Trp Gly Pro Asp Cys Ser His Pro Cys Asn Cys Ser Ala Gly His Gly 
865                 870                 875                 880 


Ser Cys Asp Ala Ile Ser Gly Leu Cys Leu Cys Glu Ala Gly Tyr Val 
                885                 890                 895     


Gly Pro Arg Cys Glu Gln Gln Cys Pro Gln Gly His Phe Gly Pro Gly 
            900                 905                 910         


Cys Glu Gln Arg Cys Gln Cys Gln His Gly Ala Ala Cys Asp His Val 
        915                 920                 925             


Ser Gly Ala Cys Thr Cys Pro Ala Gly Trp Arg Gly Thr Phe Cys Glu 
    930                 935                 940                 


His Ala Cys Pro Ala Gly Phe Phe Gly Leu Asp Cys Arg Ser Ala Cys 
945                 950                 955                 960 


Asn Cys Thr Ala Gly Ala Ala Cys Asp Ala Val Asn Gly Ser Cys Leu 
                965                 970                 975     


Cys Pro Ala Gly Arg Arg Gly Pro Arg Cys Ala Glu Thr Cys Pro Ala 
            980                 985                 990         


His Thr Tyr Gly His Asn Cys Ser  Gln Ala Cys Ala Cys  Phe Asn Gly 
        995                 1000                 1005             


Ala Ser  Cys Asp Pro Val His  Gly Gln Cys His Cys  Ala Pro Gly 
    1010                 1015                 1020             


Trp Met  Gly Pro Ser Cys Leu  Gln Ala Cys Pro Ala  Gly Leu Tyr 
    1025                 1030                 1035             


Gly Asp  Asn Cys Arg His Ser  Cys Leu Cys Gln Asn  Gly Gly Thr 
    1040                 1045                 1050             


Cys Asp  Pro Val Ser Gly His  Cys Ala Cys Pro Glu  Gly Trp Ala 
    1055                 1060                 1065             


Gly Leu  Ala Cys Glu Lys Glu  Cys Leu Pro Arg Asp  Val Arg Ala 
    1070                 1075                 1080             


Gly Cys  Arg His Ser Gly Gly  Cys Leu Asn Gly Gly  Leu Cys Asp 
    1085                 1090                 1095             


Pro His  Thr Gly Arg Cys Leu  Cys Pro Ala Gly Trp  Thr Gly Asp 
    1100                 1105                 1110             


Lys Cys  Gln Ser Pro Cys Leu  Arg Gly Trp Phe Gly  Glu Ala Cys 
    1115                 1120                 1125             


Ala Gln  Arg Cys Ser Cys Pro  Pro Gly Ala Ala Cys  His His Val 
    1130                 1135                 1140             


Thr Gly  Ala Cys Arg Cys Pro  Pro Gly Phe Thr Gly  Ser Gly Cys 
    1145                 1150                 1155             


Glu Gln  Ala Cys Pro Pro Gly  Ser Phe Gly Glu Asp  Cys Ala Gln 
    1160                 1165                 1170             


Met Cys  Gln Cys Pro Gly Glu  Asn Pro Ala Cys His  Pro Ala Thr 
    1175                 1180                 1185             


Gly Thr  Cys Ser Cys Ala Ala  Gly Tyr His Gly Pro  Ser Cys Gln 
    1190                 1195                 1200             


Gln Arg  Cys Pro Pro Gly Arg  Tyr Gly Pro Gly Cys  Glu Gln Leu 
    1205                 1210                 1215             


Cys Gly  Cys Leu Asn Gly Gly  Ser Cys Asp Ala Ala  Thr Gly Ala 
    1220                 1225                 1230             


Cys Arg  Cys Pro Thr Gly Phe  Leu Gly Thr Asp Cys  Asn Leu Thr 
    1235                 1240                 1245             


Cys Pro  Gln Gly Arg Phe Gly  Pro Asn Cys Thr His  Val Cys Gly 
    1250                 1255                 1260             


Cys Gly  Gln Gly Ala Ala Cys  Asp Pro Val Thr Gly  Thr Cys Leu 
    1265                 1270                 1275             


Cys Pro  Pro Gly Arg Ala Gly  Val Arg Cys Glu Arg  Gly Cys Pro 
    1280                 1285                 1290             


Gln Asn  Arg Phe Gly Val Gly  Cys Glu His Thr Cys  Ser Cys Arg 
    1295                 1300                 1305             


Asn Gly  Gly Leu Cys His Ala  Ser Asn Gly Ser Cys  Ser Cys Gly 
    1310                 1315                 1320             


Leu Gly  Trp Thr Gly Arg His  Cys Glu Leu Ala Cys  Pro Pro Gly 
    1325                 1330                 1335             


Arg Tyr  Gly Ala Ala Cys His  Leu Glu Cys Ser Cys  His Asn Asn 
    1340                 1345                 1350             


Ser Thr  Cys Glu Pro Ala Thr  Gly Thr Cys Arg Cys  Gly Pro Gly 
    1355                 1360                 1365             


Phe Tyr  Gly Gln Ala Cys Glu  His Pro Cys Pro Pro  Gly Phe His 
    1370                 1375                 1380             


Gly Ala  Gly Cys Gln Gly Leu  Cys Trp Cys Gln His  Gly Ala Pro 
    1385                 1390                 1395             


Cys Asp  Pro Ile Ser Gly Arg  Cys Leu Cys Pro Ala  Gly Phe His 
    1400                 1405                 1410             


Gly His  Phe Cys Glu Arg Gly  Cys Glu Pro Gly Ser  Phe Gly Glu 
    1415                 1420                 1425             


Gly Cys  His Gln Arg Cys Asp  Cys Asp Gly Gly Ala  Pro Cys Asp 
    1430                 1435                 1440             


Pro Val  Thr Gly Leu Cys Leu  Cys Pro Pro Gly Arg  Ser Gly Ala 
    1445                 1450                 1455             


Thr Cys  Asn Leu Asp Cys Arg  Arg Gly Gln Phe Gly  Pro Ser Cys 
    1460                 1465                 1470             


Thr Leu  His Cys Asp Cys Gly  Gly Gly Ala Asp Cys  Asp Pro Val 
    1475                 1480                 1485             


Ser Gly  Gln Cys His Cys Val  Asp Gly Tyr Met Gly  Pro Thr Cys 
    1490                 1495                 1500             


Arg Glu  Gly Gly Pro Leu Arg  Leu Pro Glu Asn Pro  Ser Leu Ala 
    1505                 1510                 1515             


Gln Gly  Ser Ala Gly Thr Leu  Pro Ala Ser Ser Arg  Pro Thr Ser 
    1520                 1525                 1530             


Arg Ser  Gly Gly Pro Ala Arg  His 
    1535                 1540     


<210>  2367
<211>  2778
<212>  PRT
<213>  Homo sapiens

<400>  2367

Met Ala Leu Gly Lys Val Leu Ala Met Ala Leu Val Leu Ala Leu Ala 
1               5                   10                  15      


Val Leu Gly Ser Leu Ser Pro Gly Ala Arg Ala Gly Asp Cys Lys Gly 
            20                  25                  30          


Gln Arg Gln Val Leu Arg Glu Ala Pro Gly Phe Val Thr Asp Gly Ala 
        35                  40                  45              


Gly Asn Tyr Ser Val Asn Gly Asn Cys Glu Trp Leu Ile Glu Ala Pro 
    50                  55                  60                  


Ser Pro Gln His Arg Ile Leu Leu Asp Phe Leu Phe Leu Asp Thr Glu 
65                  70                  75                  80  


Cys Thr Tyr Asp Tyr Leu Phe Val Tyr Asp Gly Asp Ser Pro Arg Gly 
                85                  90                  95      


Pro Leu Leu Ala Ser Leu Ser Gly Ser Thr Arg Pro Pro Pro Ile Glu 
            100                 105                 110         


Ala Ser Ser Gly Lys Met Leu Leu His Leu Phe Ser Asp Ala Asn Tyr 
        115                 120                 125             


Asn Leu Leu Gly Phe Asn Ala Ser Phe Arg Phe Ser Leu Cys Pro Gly 
    130                 135                 140                 


Gly Cys Gln Ser His Gly Gln Cys Gln Pro Pro Gly Val Cys Ala Cys 
145                 150                 155                 160 


Glu Pro Gly Trp Gly Gly Pro Asp Cys Gly Leu Gln Glu Cys Ser Ala 
                165                 170                 175     


Tyr Cys Gly Ser His Gly Thr Cys Ala Ser Pro Leu Gly Pro Cys Arg 
            180                 185                 190         


Cys Glu Pro Gly Phe Leu Gly Arg Ala Cys Asp Leu His Leu Trp Glu 
        195                 200                 205             


Asn Gln Gly Ala Gly Trp Trp His Asn Val Ser Ala Arg Asp Pro Ala 
    210                 215                 220                 


Phe Ser Ala Arg Ile Gly Ala Ala Gly Ala Phe Leu Ser Pro Pro Gly 
225                 230                 235                 240 


Leu Leu Ala Val Phe Gly Gly Gln Asp Leu Asn Asn Ala Leu Gly Asp 
                245                 250                 255     


Leu Val Leu Tyr Asn Phe Ser Ala Asn Thr Trp Glu Ser Trp Asp Leu 
            260                 265                 270         


Ser Pro Ala Pro Ala Ala Arg His Ser His Val Ala Val Ala Trp Ala 
        275                 280                 285             


Gly Ser Leu Val Leu Met Gly Gly Glu Leu Ala Asp Gly Ser Leu Thr 
    290                 295                 300                 


Asn Asp Val Trp Ala Phe Ser Pro Leu Gly Arg Gly His Trp Glu Leu 
305                 310                 315                 320 


Leu Ala Pro Pro Ala Ser Ser Ser Ser Gly Pro Pro Gly Leu Ala Gly 
                325                 330                 335     


His Ala Ala Ala Leu Val Asp Asp Val Trp Leu Tyr Val Ser Gly Gly 
            340                 345                 350         


Arg Thr Pro His Asp Leu Phe Ser Ser Gly Leu Phe Arg Phe Arg Leu 
        355                 360                 365             


Asp Ser Thr Ser Gly Gly Tyr Trp Glu Gln Val Ile Pro Ala Gly Gly 
    370                 375                 380                 


Arg Pro Pro Ala Ala Thr Gly His Ser Met Val Phe His Ala Pro Ser 
385                 390                 395                 400 


Arg Ala Leu Leu Val His Gly Gly His Arg Pro Ser Thr Ala Arg Phe 
                405                 410                 415     


Ser Val Arg Val Asn Ser Thr Glu Leu Phe His Val Asp Arg His Val 
            420                 425                 430         


Trp Thr Thr Leu Lys Gly Arg Asp Gly Leu Gln Gly Pro Arg Glu Arg 
        435                 440                 445             


Ala Phe His Thr Ala Ser Val Leu Gly Asn Tyr Met Val Val Tyr Gly 
    450                 455                 460                 


Gly Asn Val His Thr His Tyr Gln Glu Glu Lys Cys Tyr Glu Asp Gly 
465                 470                 475                 480 


Ile Phe Phe Tyr His Leu Gly Cys His Gln Trp Val Ser Gly Ala Glu 
                485                 490                 495     


Leu Ala Pro Pro Gly Thr Pro Glu Gly Arg Ala Ala Pro Pro Ser Gly 
            500                 505                 510         


Arg Tyr Ser His Val Ala Ala Val Leu Gly Gly Ser Val Leu Leu Val 
        515                 520                 525             


Ala Gly Gly Tyr Ser Gly Arg Pro Arg Gly Asp Leu Met Ala Tyr Lys 
    530                 535                 540                 


Val Pro Pro Phe Val Phe Gln Ala Pro Ala Pro Asp Tyr His Leu Asp 
545                 550                 555                 560 


Tyr Cys Ser Met Tyr Thr Asp His Ser Val Cys Ser Arg Asp Pro Glu 
                565                 570                 575     


Cys Ser Trp Cys Gln Gly Ala Cys Gln Ala Ala Pro Pro Pro Gly Thr 
            580                 585                 590         


Pro Leu Gly Ala Cys Pro Ala Ala Ser Cys Leu Gly Leu Gly Arg Leu 
        595                 600                 605             


Leu Gly Asp Cys Gln Ala Cys Leu Ala Phe Ser Ser Pro Thr Ala Pro 
    610                 615                 620                 


Pro Arg Gly Pro Gly Thr Leu Gly Trp Cys Val His Asn Glu Ser Cys 
625                 630                 635                 640 


Leu Pro Arg Pro Glu Gln Ala Arg Cys Arg Gly Glu Gln Ile Ser Gly 
                645                 650                 655     


Thr Val Gly Trp Trp Gly Pro Ala Pro Val Phe Val Thr Ser Leu Glu 
            660                 665                 670         


Ala Cys Val Thr Gln Ser Phe Leu Pro Gly Leu His Leu Leu Thr Phe 
        675                 680                 685             


Gln Gln Pro Pro Asn Thr Ser Gln Pro Asp Lys Glu Glu Val Gly Arg 
    690                 695                 700                 


Trp Val Ala His Gln Glu Lys Glu Thr Arg Arg Leu Gln Arg Pro Gly 
705                 710                 715                 720 


Ser Ala Arg Leu Phe Pro Leu Pro Gly Arg Asp His Lys Tyr Ala Val 
                725                 730                 735     


Glu Ile Gln Gly Gln Leu Asn Gly Ser Ala Gly Pro Gly His Ser Glu 
            740                 745                 750         


Leu Thr Leu Leu Trp Asp Arg Thr Gly Val Pro Gly Gly Ser Glu Ile 
        755                 760                 765             


Ser Phe Phe Phe Leu Glu Pro Tyr Arg Ser Ser Ser Cys Thr Ser Tyr 
    770                 775                 780                 


Ser Ser Cys Leu Gly Cys Leu Ala Asp Gln Gly Cys Gly Trp Cys Leu 
785                 790                 795                 800 


Thr Ser Ala Thr Cys His Leu Arg Gln Gly Gly Ala His Cys Gly Asp 
                805                 810                 815     


Asp Gly Ala Gly Gly Ser Leu Leu Val Leu Val Pro Thr Leu Cys Pro 
            820                 825                 830         


Leu Cys Glu Glu His Arg Asp Cys His Ala Cys Thr Gln Asp Pro Phe 
        835                 840                 845             


Cys Glu Trp His Gln Ser Thr Ser Arg Lys Gly Asp Ala Ala Cys Ser 
    850                 855                 860                 


Arg Arg Gly Arg Gly Arg Gly Ala Leu Lys Ser Pro Glu Glu Cys Pro 
865                 870                 875                 880 


Pro Leu Cys Ser Gln Arg Leu Thr Cys Glu Asp Cys Leu Ala Asn Ser 
                885                 890                 895     


Ser Gln Cys Ala Trp Cys Gln Ser Thr His Thr Cys Phe Leu Phe Ala 
            900                 905                 910         


Ala Tyr Leu Ala Arg Tyr Pro His Gly Gly Cys Arg Gly Trp Asp Asp 
        915                 920                 925             


Ser Val His Ser Glu Pro Arg Cys Arg Ser Cys Asp Gly Phe Leu Thr 
    930                 935                 940                 


Cys His Glu Cys Leu Gln Ser His Glu Cys Gly Trp Cys Gly Asn Glu 
945                 950                 955                 960 


Asp Asn Pro Thr Leu Gly Arg Cys Leu Gln Gly Asp Phe Ser Gly Pro 
                965                 970                 975     


Leu Gly Gly Gly Asn Cys Ser Leu Trp Val Gly Glu Gly Leu Gly Leu 
            980                 985                 990         


Pro Val Ala Leu Pro Ala Arg Trp  Ala Tyr Ala Arg Cys  Pro Asp Val 
        995                 1000                 1005             


Asp Glu  Cys Arg Leu Gly Leu  Ala Arg Cys His Pro  Arg Ala Thr 
    1010                 1015                 1020             


Cys Leu  Asn Thr Pro Leu Ser  Tyr Glu Cys His Cys  Gln Arg Gly 
    1025                 1030                 1035             


Tyr Gln  Gly Asp Gly Ile Ser  His Cys Asn Arg Thr  Cys Leu Glu 
    1040                 1045                 1050             


Asp Cys  Gly His Gly Val Cys  Ser Gly Pro Pro Asp  Phe Thr Cys 
    1055                 1060                 1065             


Val Cys  Asp Leu Gly Trp Thr  Ser Asp Leu Pro Pro  Pro Thr Pro 
    1070                 1075                 1080             


Ala Pro  Gly Pro Pro Ala Pro  Arg Cys Ser Arg Asp  Cys Gly Cys 
    1085                 1090                 1095             


Ser Phe  His Ser His Cys Arg  Lys Arg Gly Pro Gly  Phe Cys Asp 
    1100                 1105                 1110             


Glu Cys  Gln Asp Trp Thr Trp  Gly Glu His Cys Glu  Arg Cys Arg 
    1115                 1120                 1125             


Pro Gly  Ser Phe Gly Asn Ala  Thr Gly Ser Arg Gly  Cys Arg Pro 
    1130                 1135                 1140             


Cys Gln  Cys Asn Gly His Gly  Asp Pro Arg Arg Gly  His Cys Asp 
    1145                 1150                 1155             


Asn Leu  Ser Gly Leu Cys Phe  Cys Gln Asp His Thr  Glu Gly Ala 
    1160                 1165                 1170             


His Cys  Gln Leu Cys Ser Pro  Gly Tyr Tyr Gly Asp  Pro Arg Ala 
    1175                 1180                 1185             


Gly Gly  Ser Cys Phe Arg Glu  Cys Gly Gly Arg Ala  Leu Leu Thr 
    1190                 1195                 1200             


Asn Val  Ser Ser Val Ala Leu  Gly Ser Arg Arg Val  Gly Gly Leu 
    1205                 1210                 1215             


Leu Pro  Pro Gly Gly Gly Ala  Ala Arg Ala Gly Pro  Gly Leu Ser 
    1220                 1225                 1230             


Tyr Cys  Val Trp Val Val Ser  Ala Thr Glu Glu Leu  Gln Pro Cys 
    1235                 1240                 1245             


Ala Pro  Gly Thr Leu Cys Pro  Pro Leu Thr Leu Thr  Phe Ser Pro 
    1250                 1255                 1260             


Asp Ser  Ser Thr Pro Cys Thr  Leu Ser Tyr Val Leu  Ala Phe Asp 
    1265                 1270                 1275             


Gly Phe  Pro Arg Phe Leu Asp  Thr Gly Val Val Gln  Ser Asp Arg 
    1280                 1285                 1290             


Ser Leu  Ile Ala Ala Phe Cys  Gly Gln Arg Arg Asp  Arg Pro Leu 
    1295                 1300                 1305             


Thr Val  Gln Ala Leu Ser Gly  Leu Leu Val Leu His  Trp Glu Ala 
    1310                 1315                 1320             


Asn Gly  Ser Ser Ser Trp Gly  Phe Asn Ala Ser Val  Gly Ser Ala 
    1325                 1330                 1335             


Arg Cys  Gly Ser Gly Gly Pro  Gly Ser Cys Pro Val  Pro Gln Glu 
    1340                 1345                 1350             


Cys Val  Pro Gln Asp Gly Ala  Ala Gly Ala Gly Leu  Cys Arg Cys 
    1355                 1360                 1365             


Pro Gln  Gly Trp Ala Gly Pro  His Cys Arg Met Ala  Leu Cys Pro 
    1370                 1375                 1380             


Glu Asn  Cys Asn Ala His Thr  Gly Ala Gly Thr Cys  Asn Gln Ser 
    1385                 1390                 1395             


Leu Gly  Val Cys Ile Cys Ala  Glu Gly Phe Gly Gly  Pro Asp Cys 
    1400                 1405                 1410             


Ala Thr  Lys Leu Asp Gly Gly  Gln Leu Val Trp Glu  Thr Leu Met 
    1415                 1420                 1425             


Asp Ser  Arg Leu Ser Ala Asp  Thr Ala Ser Arg Phe  Leu His Arg 
    1430                 1435                 1440             


Leu Gly  His Thr Met Val Asp  Gly Pro Asp Ala Thr  Leu Trp Met 
    1445                 1450                 1455             


Phe Gly  Gly Leu Gly Leu Pro  Gln Gly Leu Leu Gly  Asn Leu Tyr 
    1460                 1465                 1470             


Arg Tyr  Ser Val Ser Glu Arg  Arg Trp Thr Gln Met  Leu Ala Gly 
    1475                 1480                 1485             


Ala Glu  Asp Gly Gly Pro Gly  Pro Ser Pro Arg Ser  Phe His Ala 
    1490                 1495                 1500             


Ala Ala  Tyr Val Pro Ala Gly  Arg Gly Ala Met Tyr  Leu Leu Gly 
    1505                 1510                 1515             


Gly Leu  Thr Ala Gly Gly Val  Thr Arg Asp Phe Trp  Val Leu Asn 
    1520                 1525                 1530             


Leu Thr  Thr Leu Gln Trp Arg  Gln Glu Lys Ala Pro  Gln Thr Val 
    1535                 1540                 1545             


Glu Leu  Pro Ala Val Ala Gly  His Thr Leu Thr Ala  Arg Arg Gly 
    1550                 1555                 1560             


Leu Ser  Leu Leu Leu Val Gly  Gly Tyr Ser Pro Glu  Asn Gly Phe 
    1565                 1570                 1575             


Asn Gln  Gln Leu Leu Glu Tyr  Gln Leu Ala Thr Gly  Thr Trp Val 
    1580                 1585                 1590             


Ser Gly  Ala Gln Ser Gly Thr  Pro Pro Thr Gly Leu  Tyr Gly His 
    1595                 1600                 1605             


Ser Ala  Val Tyr His Glu Ala  Thr Asp Ser Leu Tyr  Val Phe Gly 
    1610                 1615                 1620             


Gly Phe  Arg Phe His Val Glu  Leu Ala Ala Pro Ser  Pro Glu Leu 
    1625                 1630                 1635             


Tyr Ser  Leu His Cys Pro Asp  Arg Thr Trp Ser Leu  Leu Ala Pro 
    1640                 1645                 1650             


Ser Gln  Gly Ala Lys Arg Asp  Arg Met Arg Asn Val  Arg Gly Ser 
    1655                 1660                 1665             


Ser Arg  Gly Leu Gly Gln Val  Pro Gly Glu Gln Pro  Gly Ser Trp 
    1670                 1675                 1680             


Gly Phe  Arg Glu Val Arg Lys  Lys Met Ala Leu Trp  Ala Ala Leu 
    1685                 1690                 1695             


Ala Gly  Thr Gly Gly Phe Leu  Glu Glu Ile Ser Pro  His Leu Lys 
    1700                 1705                 1710             


Glu Pro  Arg Pro Arg Leu Phe  His Ala Ser Ala Leu  Leu Gly Asp 
    1715                 1720                 1725             


Thr Met  Val Val Leu Gly Gly  Arg Ser Asp Pro Asp  Glu Phe Ser 
    1730                 1735                 1740             


Ser Asp  Val Leu Leu Tyr Gln  Val Asn Cys Asn Ala  Trp Leu Leu 
    1745                 1750                 1755             


Pro Asp  Leu Thr Arg Ser Ala  Ser Val Gly Pro Pro  Met Glu Glu 
    1760                 1765                 1770             


Ser Val  Ala His Ala Val Ala  Ala Val Gly Ser Arg  Leu Tyr Ile 
    1775                 1780                 1785             


Ser Gly  Gly Phe Gly Gly Val  Ala Leu Gly Arg Leu  Leu Ala Leu 
    1790                 1795                 1800             


Thr Leu  Pro Pro Asp Pro Cys  Arg Leu Leu Ser Ser  Pro Glu Ala 
    1805                 1810                 1815             


Cys Asn  Gln Ser Gly Ala Cys  Thr Trp Cys His Gly  Ala Cys Leu 
    1820                 1825                 1830             


Ser Gly  Asp Gln Ala His Arg  Leu Gly Cys Gly Gly  Ser Pro Cys 
    1835                 1840                 1845             


Ser Pro  Met Pro Arg Ser Pro  Glu Glu Cys Arg Arg  Leu Arg Thr 
    1850                 1855                 1860             


Cys Ser  Glu Cys Leu Ala Arg  His Pro Arg Thr Leu  Gln Pro Gly 
    1865                 1870                 1875             


Asp Gly  Glu Ala Ser Thr Pro  Arg Cys Lys Trp Cys  Thr Asn Cys 
    1880                 1885                 1890             


Pro Glu  Gly Ala Cys Ile Gly  Arg Asn Gly Ser Cys  Thr Ser Glu 
    1895                 1900                 1905             


Asn Asp  Cys Arg Ile Asn Gln  Arg Glu Val Phe Trp  Ala Gly Asn 
    1910                 1915                 1920             


Cys Ser  Glu Ala Ala Cys Gly  Ala Ala Asp Cys Glu  Gln Cys Thr 
    1925                 1930                 1935             


Arg Glu  Gly Lys Cys Met Trp  Thr Arg Gln Phe Lys  Arg Thr Gly 
    1940                 1945                 1950             


Glu Thr  Arg Arg Ile Leu Ser  Val Gln Pro Thr Tyr  Asp Trp Thr 
    1955                 1960                 1965             


Cys Phe  Ser His Ser Leu Leu  Asn Val Ser Pro Met  Pro Val Glu 
    1970                 1975                 1980             


Ser Ser  Pro Pro Leu Pro Cys  Pro Thr Pro Cys His  Leu Leu Pro 
    1985                 1990                 1995             


Asn Cys  Thr Ser Cys Leu Asp  Ser Lys Gly Ala Asp  Gly Gly Trp 
    2000                 2005                 2010             


Gln His  Cys Val Trp Ser Ser  Ser Leu Gln Gln Cys  Leu Ser Pro 
    2015                 2020                 2025             


Ser Tyr  Leu Pro Leu Arg Cys  Met Ala Gly Gly Cys  Gly Arg Leu 
    2030                 2035                 2040             


Leu Arg  Gly Pro Glu Ser Cys  Ser Leu Gly Cys Ala  Gln Ala Thr 
    2045                 2050                 2055             


Gln Cys  Ala Leu Cys Leu Arg  Arg Pro His Cys Gly  Trp Cys Ala 
    2060                 2065                 2070             


Trp Gly  Gly Gln Asp Gly Gly  Gly Arg Cys Met Glu  Gly Gly Leu 
    2075                 2080                 2085             


Ser Gly  Pro Arg Asp Gly Leu  Thr Cys Gly Arg Pro  Gly Ala Ser 
    2090                 2095                 2100             


Trp Ala  Phe Leu Ser Cys Pro  Pro Glu Asp Glu Cys  Ala Asn Gly 
    2105                 2110                 2115             


His His  Asp Cys Asn Glu Thr  Gln Asn Cys His Asp  Gln Pro His 
    2120                 2125                 2130             


Gly Tyr  Glu Cys Ser Cys Lys  Thr Gly Tyr Thr Met  Asp Asn Met 
    2135                 2140                 2145             


Thr Gly  Leu Cys Arg Pro Val  Cys Ala Gln Gly Cys  Val Asn Gly 
    2150                 2155                 2160             


Ser Cys  Val Glu Pro Asp His  Cys Arg Cys His Phe  Gly Phe Val 
    2165                 2170                 2175             


Gly Arg  Asn Cys Ser Thr Glu  Cys Arg Cys Asn Arg  His Ser Glu 
    2180                 2185                 2190             


Cys Ala  Gly Val Gly Ala Arg  Asp His Cys Leu Leu  Cys Arg Asn 
    2195                 2200                 2205             


His Thr  Lys Gly Ser His Cys  Glu Gln Cys Leu Pro  Leu Phe Val 
    2210                 2215                 2220             


Gly Ser  Ala Val Gly Gly Gly  Thr Cys Arg Pro Cys  His Ala Phe 
    2225                 2230                 2235             


Cys Arg  Gly Asn Ser His Ile  Cys Ile Ser Arg Lys  Glu Leu Gln 
    2240                 2245                 2250             


Met Ser  Lys Gly Glu Pro Lys  Lys Tyr Ser Leu Asp  Pro Glu Glu 
    2255                 2260                 2265             


Ile Glu  Asn Trp Val Thr Glu  Gly Pro Ser Glu Asp  Glu Ala Val 
    2270                 2275                 2280             


Cys Val  Asn Cys Gln Asn Asn  Ser Tyr Gly Glu Lys  Cys Glu Ser 
    2285                 2290                 2295             


Cys Leu  Gln Gly Tyr Phe Leu  Leu Asp Gly Lys Cys  Thr Lys Cys 
    2300                 2305                 2310             


Gln Cys  Asn Gly His Ala Asp  Thr Cys Asn Glu Gln  Asp Gly Thr 
    2315                 2320                 2325             


Gly Cys  Pro Cys Gln Asn Asn  Thr Glu Thr Gly Thr  Cys Gln Gly 
    2330                 2335                 2340             


Ser Ser  Pro Ser Asp Arg Arg  Asp Cys Tyr Lys Tyr  Gln Cys Ala 
    2345                 2350                 2355             


Lys Cys  Arg Glu Ser Phe His  Gly Ser Pro Leu Gly  Gly Gln Gln 
    2360                 2365                 2370             


Cys Tyr  Arg Leu Ile Ser Val  Glu Gln Glu Cys Cys  Leu Asp Pro 
    2375                 2380                 2385             


Thr Ser  Gln Thr Asn Cys Phe  His Glu Pro Lys Arg  Arg Ala Leu 
    2390                 2395                 2400             


Gly Pro  Gly Arg Thr Val Leu  Phe Gly Val Gln Pro  Lys Phe Thr 
    2405                 2410                 2415             


Asn Val  Asp Ile Arg Leu Thr  Leu Asp Val Thr Phe  Gly Ala Val 
    2420                 2425                 2430             


Asp Leu  Tyr Val Ser Thr Ser  Tyr Asp Thr Phe Val  Val Arg Val 
    2435                 2440                 2445             


Ala Pro  Asp Thr Gly Val His  Thr Val His Ile Gln  Pro Pro Pro 
    2450                 2455                 2460             


Ala Pro  Pro Pro Pro Pro Pro  Pro Ala Asp Gly Gly  Pro Arg Gly 
    2465                 2470                 2475             


Ala Gly  Asp Pro Gly Gly Ala  Gly Ala Ser Ser Gly  Pro Gly Ala 
    2480                 2485                 2490             


Pro Ala  Glu Pro Arg Val Arg  Glu Val Trp Pro Arg  Gly Leu Ile 
    2495                 2500                 2505             


Thr Tyr  Val Thr Val Thr Glu  Pro Ser Ala Val Leu  Val Val Arg 
    2510                 2515                 2520             


Gly Val  Arg Asp Arg Leu Val  Ile Thr Tyr Pro His  Glu His His 
    2525                 2530                 2535             


Ala Leu  Lys Ser Ser Arg Phe  Tyr Leu Leu Leu Leu  Gly Val Gly 
    2540                 2545                 2550             


Asp Pro  Ser Gly Pro Gly Ala  Asn Gly Ser Ala Asp  Ser Gln Gly 
    2555                 2560                 2565             


Leu Leu  Phe Phe Arg Gln Asp  Gln Ala His Ile Asp  Leu Phe Val 
    2570                 2575                 2580             


Phe Phe  Ser Val Phe Phe Ser  Cys Phe Phe Leu Phe  Leu Ser Leu 
    2585                 2590                 2595             


Cys Val  Leu Leu Trp Lys Ala  Lys Gln Ala Leu Asp  Gln Arg Gln 
    2600                 2605                 2610             


Glu Gln  Arg Arg His Leu Gln  Glu Met Thr Lys Met  Ala Ser Arg 
    2615                 2620                 2625             


Pro Phe  Ala Lys Val Thr Val  Cys Phe Pro Pro Asp  Pro Thr Ala 
    2630                 2635                 2640             


Pro Ala  Ser Ala Trp Lys Pro  Ala Gly Leu Pro Pro  Pro Ala Phe 
    2645                 2650                 2655             


Arg Arg  Ser Glu Pro Phe Leu  Ala Pro Leu Leu Leu  Thr Gly Ala 
    2660                 2665                 2670             


Gly Gly  Pro Trp Gly Pro Met  Gly Gly Gly Cys Cys  Pro Pro Ala 
    2675                 2680                 2685             


Ile Pro  Ala Thr Thr Ala Gly  Leu Arg Ala Gly Pro  Ile Thr Leu 
    2690                 2695                 2700             


Glu Pro  Thr Glu Asp Gly Met  Ala Gly Val Ala Thr  Leu Leu Leu 
    2705                 2710                 2715             


Gln Leu  Pro Gly Gly Pro His  Ala Pro Asn Gly Ala  Cys Leu Gly 
    2720                 2725                 2730             


Ser Ala  Leu Val Thr Leu Arg  His Arg Leu His Glu  Tyr Cys Gly 
    2735                 2740                 2745             


Gly Gly  Gly Gly Ala Gly Gly  Ser Gly His Gly Thr  Gly Ala Gly 
    2750                 2755                 2760             


Arg Lys  Gly Leu Leu Ser Gln  Asp Asn Leu Thr Ser  Met Ser Leu 
    2765                 2770                 2775             


<210>  2368
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  2368

Met Leu Val Leu Leu Ala Gly Ile Phe Val Val His Ile Ala Thr Val 
1               5                   10                  15      


Ile Met Leu Phe Val Ser Thr Ile Ala Asn Val Trp Leu Val Ser Asn 
            20                  25                  30          


Thr Val Asp Ala Ser Val Gly Leu Trp Lys Asn Cys Thr Asn Ile Ser 
        35                  40                  45              


Cys Ser Asp Ser Leu Ser Tyr Ala Ser Glu Asp Ala Leu Lys Thr Val 
    50                  55                  60                  


Gln Ala Phe Met Ile Leu Ser Ile Ile Phe Cys Val Ile Ala Leu Leu 
65                  70                  75                  80  


Val Phe Val Phe Gln Leu Phe Thr Met Glu Lys Gly Asn Arg Phe Phe 
                85                  90                  95      


Leu Ser Gly Ala Thr Thr Leu Val Cys Trp Leu Cys Ile Leu Val Gly 
            100                 105                 110         


Val Ser Ile Tyr Thr Ser His Tyr Ala Asn Arg Asp Gly Thr Gln Tyr 
        115                 120                 125             


His His Gly Tyr Ser Tyr Ile Leu Gly Trp Ile Cys Phe Cys Phe Ser 
    130                 135                 140                 


Phe Ile Ile Gly Val Leu Tyr Leu Val Leu Arg Lys Lys 
145                 150                 155         


<210>  2369
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  2369

Met Leu Val Leu Leu Ala Phe Ile Ile Ala Phe His Ile Thr Ser Ala 
1               5                   10                  15      


Ala Leu Leu Phe Ile Ala Thr Val Asp Asn Ala Trp Trp Val Gly Asp 
            20                  25                  30          


Glu Phe Phe Ala Asp Val Trp Arg Ile Cys Thr Asn Asn Thr Asn Cys 
        35                  40                  45              


Thr Val Ile Asn Asp Ser Phe Gln Glu Tyr Ser Thr Leu Gln Ala Val 
    50                  55                  60                  


Gln Ala Thr Met Ile Leu Ser Thr Ile Leu Cys Cys Ile Ala Phe Phe 
65                  70                  75                  80  


Ile Phe Val Leu Gln Leu Phe Arg Leu Lys Gln Gly Glu Arg Phe Val 
                85                  90                  95      


Leu Thr Ser Ile Ile Gln Leu Met Ser Cys Leu Cys Val Met Ile Ala 
            100                 105                 110         


Ala Ser Ile Tyr Thr Asp Arg Arg Glu Asp Ile His Asp Lys Asn Ala 
        115                 120                 125             


Lys Phe Tyr Pro Val Thr Arg Glu Gly Ser Tyr Gly Tyr Ser Tyr Ile 
    130                 135                 140                 


Leu Ala Trp Val Ala Phe Ala Cys Thr Phe Ile Ser Gly Met Met Tyr 
145                 150                 155                 160 


Leu Ile Leu Arg Lys Arg Lys 
                165         


<210>  2370
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  2370

Met Ser Leu Leu Leu Leu Val Val Ser Ala Leu His Ile Leu Ile Leu 
1               5                   10                  15      


Ile Leu Leu Phe Val Ala Thr Leu Asp Lys Ser Trp Trp Thr Leu Pro 
            20                  25                  30          


Gly Lys Glu Ser Leu Asn Leu Trp Tyr Asp Cys Thr Trp Asn Asn Asp 
        35                  40                  45              


Thr Lys Thr Trp Ala Cys Ser Asn Val Ser Glu Asn Gly Trp Leu Lys 
    50                  55                  60                  


Ala Val Gln Val Leu Met Val Leu Ser Leu Ile Leu Cys Cys Leu Ser 
65                  70                  75                  80  


Phe Ile Leu Phe Met Phe Gln Leu Tyr Thr Met Arg Arg Gly Gly Leu 
                85                  90                  95      


Phe Tyr Ala Thr Gly Leu Cys Gln Leu Cys Thr Ser Val Ala Val Phe 
            100                 105                 110         


Thr Gly Ala Leu Ile Tyr Ala Ile His Ala Glu Glu Ile Leu Glu Lys 
        115                 120                 125             


His Pro Arg Gly Gly Ser Phe Gly Tyr Cys Phe Ala Leu Ala Trp Val 
    130                 135                 140                 


Ala Phe Pro Leu Ala Leu Val Ser Gly Ile Ile Tyr Ile His Leu Arg 
145                 150                 155                 160 


Lys Arg Glu 
            


<210>  2371
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  2371

Met Thr Ala Gly Arg Arg Met Glu Met Leu Cys Ala Gly Arg Val Pro 
1               5                   10                  15      


Ala Leu Leu Leu Cys Leu Gly Phe His Leu Leu Gln Ala Val Leu Ser 
            20                  25                  30          


Thr Thr Val Ile Pro Ser Cys Ile Pro Gly Glu Ser Ser Asp Asn Cys 
        35                  40                  45              


Thr Ala Leu Val Gln Thr Glu Asp Asn Pro Arg Val Ala Gln Val Ser 
    50                  55                  60                  


Ile Thr Lys Cys Ser Ser Asp Met Asn Gly Tyr Cys Leu His Gly Gln 
65                  70                  75                  80  


Cys Ile Tyr Leu Val Asp Met Ser Gln Asn Tyr Cys Arg Cys Glu Val 
                85                  90                  95      


Gly Tyr Thr Gly Val Arg Cys Glu His Phe Phe Leu Thr Val His Gln 
            100                 105                 110         


Pro Leu Ser Lys Glu Tyr Val Ala Leu Thr Val Ile Leu Ile Ile Leu 
        115                 120                 125             


Phe Leu Ile Thr Val Val Gly Ser Thr Tyr Tyr Phe Cys Arg Trp Tyr 
    130                 135                 140                 


Arg Asn Arg Lys Ser Lys Glu Pro Lys Lys Glu Tyr Glu Arg Val Thr 
145                 150                 155                 160 


Ser Gly Asp Pro Glu Leu Pro Gln Val 
                165                 


<210>  2372
<211>  977
<212>  PRT
<213>  Homo sapiens

<400>  2372

Met Pro Ala Arg Arg Leu Leu Leu Leu Leu Thr Leu Leu Leu Pro Gly 
1               5                   10                  15      


Leu Gly Ile Phe Gly Ser Thr Ser Thr Val Thr Leu Pro Glu Thr Leu 
            20                  25                  30          


Leu Phe Val Ser Thr Leu Asp Gly Ser Leu His Ala Val Ser Lys Arg 
        35                  40                  45              


Thr Gly Ser Ile Lys Trp Thr Leu Lys Glu Asp Pro Val Leu Gln Val 
    50                  55                  60                  


Pro Thr His Val Glu Glu Pro Ala Phe Leu Pro Asp Pro Asn Asp Gly 
65                  70                  75                  80  


Ser Leu Tyr Thr Leu Gly Ser Lys Asn Asn Glu Gly Leu Thr Lys Leu 
                85                  90                  95      


Pro Phe Thr Ile Pro Glu Leu Val Gln Ala Ser Pro Cys Arg Ser Ser 
            100                 105                 110         


Asp Gly Ile Leu Tyr Met Gly Lys Lys Gln Asp Ile Trp Tyr Val Ile 
        115                 120                 125             


Asp Leu Leu Thr Gly Glu Lys Gln Gln Thr Leu Ser Ser Ala Phe Ala 
    130                 135                 140                 


Asp Ser Leu Cys Pro Ser Thr Ser Leu Leu Tyr Leu Gly Arg Thr Glu 
145                 150                 155                 160 


Tyr Thr Ile Thr Met Tyr Asp Thr Lys Thr Arg Glu Leu Arg Trp Asn 
                165                 170                 175     


Ala Thr Tyr Phe Asp Tyr Ala Ala Ser Leu Pro Glu Asp Asp Val Asp 
            180                 185                 190         


Tyr Lys Met Ser His Phe Val Ser Asn Gly Asp Gly Leu Val Val Thr 
        195                 200                 205             


Val Asp Ser Glu Ser Gly Asp Val Leu Trp Ile Gln Asn Tyr Ala Ser 
    210                 215                 220                 


Pro Val Val Ala Phe Tyr Val Trp Gln Arg Glu Gly Leu Arg Lys Val 
225                 230                 235                 240 


Met His Ile Asn Val Ala Val Glu Thr Leu Arg Tyr Leu Thr Phe Met 
                245                 250                 255     


Ser Gly Glu Val Gly Arg Ile Thr Lys Trp Lys Tyr Pro Phe Pro Lys 
            260                 265                 270         


Glu Thr Glu Ala Lys Ser Lys Leu Thr Pro Thr Leu Tyr Val Gly Lys 
        275                 280                 285             


Tyr Ser Thr Ser Leu Tyr Ala Ser Pro Ser Met Val His Glu Gly Val 
    290                 295                 300                 


Ala Val Val Pro Arg Gly Ser Thr Leu Pro Leu Leu Glu Gly Pro Gln 
305                 310                 315                 320 


Thr Asp Gly Val Thr Ile Gly Asp Lys Gly Glu Cys Val Ile Thr Pro 
                325                 330                 335     


Ser Thr Asp Val Lys Phe Asp Pro Gly Leu Lys Ser Lys Asn Lys Leu 
            340                 345                 350         


Asn Tyr Leu Arg Asn Tyr Trp Leu Leu Ile Gly His His Glu Thr Pro 
        355                 360                 365             


Leu Ser Ala Ser Thr Lys Met Leu Glu Arg Phe Pro Asn Asn Leu Pro 
    370                 375                 380                 


Lys His Arg Glu Asn Val Ile Pro Ala Asp Ser Glu Lys Lys Ser Phe 
385                 390                 395                 400 


Glu Glu Val Ile Asn Leu Val Asp Gln Thr Ser Glu Asn Ala Pro Thr 
                405                 410                 415     


Thr Val Ser Arg Asp Val Glu Glu Lys Pro Ala His Ala Pro Ala Arg 
            420                 425                 430         


Pro Glu Ala Pro Val Asp Ser Met Leu Lys Asp Met Ala Thr Ile Ile 
        435                 440                 445             


Leu Ser Thr Phe Leu Leu Ile Gly Trp Val Ala Phe Ile Ile Thr Tyr 
    450                 455                 460                 


Pro Leu Ser Met His Gln Gln Gln Gln Leu Gln His Gln Gln Phe Gln 
465                 470                 475                 480 


Lys Glu Leu Glu Lys Ile Gln Leu Leu Gln Gln Gln Gln Gln Gln Leu 
                485                 490                 495     


Pro Phe His Pro Pro Gly Asp Thr Ala Gln Asp Gly Glu Leu Leu Asp 
            500                 505                 510         


Thr Ser Gly Pro Tyr Ser Glu Ser Ser Gly Thr Ser Ser Pro Ser Thr 
        515                 520                 525             


Ser Pro Arg Ala Ser Asn His Ser Leu Cys Ser Gly Ser Ser Ala Ser 
    530                 535                 540                 


Lys Ala Gly Ser Ser Pro Ser Leu Glu Gln Asp Asp Gly Asp Glu Glu 
545                 550                 555                 560 


Thr Ser Val Val Ile Val Gly Lys Ile Ser Phe Cys Pro Lys Asp Val 
                565                 570                 575     


Leu Gly His Gly Ala Glu Gly Thr Ile Val Tyr Arg Gly Met Phe Asp 
            580                 585                 590         


Asn Arg Asp Val Ala Val Lys Arg Ile Leu Pro Glu Cys Phe Ser Phe 
        595                 600                 605             


Ala Asp Arg Glu Val Gln Leu Leu Arg Glu Ser Asp Glu His Pro Asn 
    610                 615                 620                 


Val Ile Arg Tyr Phe Cys Thr Glu Lys Asp Arg Gln Phe Gln Tyr Ile 
625                 630                 635                 640 


Ala Ile Glu Leu Cys Ala Ala Thr Leu Gln Glu Tyr Val Glu Gln Lys 
                645                 650                 655     


Asp Phe Ala His Leu Gly Leu Glu Pro Ile Thr Leu Leu Gln Gln Thr 
            660                 665                 670         


Thr Ser Gly Leu Ala His Leu His Ser Leu Asn Ile Val His Arg Asp 
        675                 680                 685             


Leu Lys Pro His Asn Ile Leu Ile Ser Met Pro Asn Ala His Gly Lys 
    690                 695                 700                 


Ile Lys Ala Met Ile Ser Asp Phe Gly Leu Cys Lys Lys Leu Ala Val 
705                 710                 715                 720 


Gly Arg His Ser Phe Ser Arg Arg Ser Gly Val Pro Gly Thr Glu Gly 
                725                 730                 735     


Trp Ile Ala Pro Glu Met Leu Ser Glu Asp Cys Lys Glu Asn Pro Thr 
            740                 745                 750         


Tyr Thr Val Asp Ile Phe Ser Ala Gly Cys Val Phe Tyr Tyr Val Ile 
        755                 760                 765             


Ser Glu Gly Ser His Pro Phe Gly Lys Ser Leu Gln Arg Gln Ala Asn 
    770                 775                 780                 


Ile Leu Leu Gly Ala Cys Ser Leu Asp Cys Leu His Pro Glu Lys His 
785                 790                 795                 800 


Glu Asp Val Ile Ala Arg Glu Leu Ile Glu Lys Met Ile Ala Met Asp 
                805                 810                 815     


Pro Gln Lys Arg Pro Ser Ala Lys His Val Leu Lys His Pro Phe Phe 
            820                 825                 830         


Trp Ser Leu Glu Lys Gln Leu Gln Phe Phe Gln Asp Val Ser Asp Arg 
        835                 840                 845             


Ile Glu Lys Glu Ser Leu Asp Gly Pro Ile Val Lys Gln Leu Glu Arg 
    850                 855                 860                 


Gly Gly Arg Ala Val Val Lys Met Asp Trp Arg Glu Asn Ile Thr Val 
865                 870                 875                 880 


Pro Leu Gln Thr Asp Leu Arg Lys Phe Arg Thr Tyr Lys Gly Gly Ser 
                885                 890                 895     


Val Arg Asp Leu Leu Arg Ala Met Arg Asn Lys Lys His His Tyr Arg 
            900                 905                 910         


Glu Leu Pro Ala Glu Val Arg Glu Thr Leu Gly Ser Leu Pro Asp Asp 
        915                 920                 925             


Phe Val Cys Tyr Phe Thr Ser Arg Phe Pro His Leu Leu Ala His Thr 
    930                 935                 940                 


Tyr Arg Ala Met Glu Leu Cys Ser His Glu Arg Leu Phe Gln Pro Tyr 
945                 950                 955                 960 


Tyr Phe His Glu Pro Pro Glu Pro Gln Pro Pro Val Thr Pro Asp Ala 
                965                 970                 975     


Leu 
    


<210>  2373
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  2373

Met Arg Cys Cys His Ile Cys Lys Leu Pro Gly Arg Val Met Gly Ile 
1               5                   10                  15      


Arg Val Leu Arg Leu Ser Leu Val Val Ile Leu Val Leu Leu Leu Val 
            20                  25                  30          


Ala Gly Ala Leu Thr Ala Leu Leu Pro Ser Val Lys Glu Asp Lys Met 
        35                  40                  45              


Leu Met Leu Arg Arg Glu Ile Lys Ser Gln Gly Lys Ser Thr Met Asp 
    50                  55                  60                  


Ser Phe Thr Leu Ile Met Gln Thr Tyr Asn Arg Thr Asp Leu Leu Leu 
65                  70                  75                  80  


Lys Leu Leu Asn His Tyr Gln Ala Val Pro Asn Leu His Lys Val Ile 
                85                  90                  95      


Val Val Trp Asn Asn Ile Gly Glu Lys Ala Pro Asp Glu Leu Trp Asn 
            100                 105                 110         


Ser Leu Gly Pro His Pro Ile Pro Val Ile Phe Lys Gln Gln Thr Ala 
        115                 120                 125             


Asn Arg Met Arg Asn Arg Leu Gln Val Phe Pro Glu Leu Glu Thr Asn 
    130                 135                 140                 


Ala Val Leu Met Val Asp Asp Asp Thr Leu Ile Ser Thr Pro Asp Leu 
145                 150                 155                 160 


Val Phe Ala Phe Ser Val Trp Gln Gln Phe Pro Asp Gln Ile Val Gly 
                165                 170                 175     


Phe Val Pro Arg Lys His Val Ser Thr Ser Ser Gly Ile Tyr Ser Tyr 
            180                 185                 190         


Gly Ser Phe Glu Met Gln Ala Pro Gly Ser Gly Asn Gly Asp Gln Tyr 
        195                 200                 205             


Ser Met Val Leu Ile Gly Ala Ser Phe Phe Asn Ser Lys Tyr Leu Glu 
    210                 215                 220                 


Leu Phe Gln Arg Gln Pro Ala Ala Val His Ala Leu Ile Asp Asp Thr 
225                 230                 235                 240 


Gln Asn Cys Asp Asp Ile Ala Met Asn Phe Ile Ile Ala Lys His Ile 
                245                 250                 255     


Gly Lys Thr Ser Gly Ile Phe Val Lys Pro Val Asn Met Asp Asn Leu 
            260                 265                 270         


Glu Lys Glu Thr Asn Ser Gly Tyr Ser Gly Met Trp His Arg Ala Glu 
        275                 280                 285             


His Ala Leu Gln Arg Ser Tyr Cys Ile Asn Lys Leu Val Asn Ile Tyr 
    290                 295                 300                 


Asp Ser Met Pro Leu Arg Tyr Ser Asn Ile Met Ile Ser Gln Phe Gly 
305                 310                 315                 320 


Phe Pro Tyr Ala Asn Tyr Lys Arg Lys Ile 
                325                 330 


<210>  2374
<211>  919
<212>  PRT
<213>  Homo sapiens

<400>  2374

Met Thr Gly Tyr Thr Met Leu Arg Asn Gly Gly Ala Gly Asn Gly Gly 
1               5                   10                  15      


Gln Thr Cys Met Leu Arg Trp Ser Asn Arg Ile Arg Leu Thr Trp Leu 
            20                  25                  30          


Ser Phe Thr Leu Phe Val Ile Leu Val Phe Phe Pro Leu Ile Ala His 
        35                  40                  45              


Tyr Tyr Leu Thr Thr Leu Asp Glu Ala Asp Glu Ala Gly Lys Arg Ile 
    50                  55                  60                  


Phe Gly Pro Arg Val Gly Asn Glu Leu Cys Glu Val Lys His Val Leu 
65                  70                  75                  80  


Asp Leu Cys Arg Ile Arg Glu Ser Val Ser Glu Glu Leu Leu Gln Leu 
                85                  90                  95      


Glu Ala Lys Arg Gln Glu Leu Asn Ser Glu Ile Ala Lys Leu Asn Leu 
            100                 105                 110         


Lys Ile Glu Ala Cys Lys Lys Ser Ile Glu Asn Ala Lys Gln Asp Leu 
        115                 120                 125             


Leu Gln Leu Lys Asn Val Ile Ser Gln Thr Glu His Ser Tyr Lys Glu 
    130                 135                 140                 


Leu Met Ala Gln Asn Gln Pro Lys Leu Ser Leu Pro Ile Arg Leu Leu 
145                 150                 155                 160 


Pro Glu Lys Asp Asp Ala Gly Leu Pro Pro Pro Lys Ala Thr Arg Gly 
                165                 170                 175     


Cys Arg Leu His Asn Cys Phe Asp Tyr Ser Arg Cys Pro Leu Thr Ser 
            180                 185                 190         


Gly Phe Pro Val Tyr Val Tyr Asp Ser Asp Gln Phe Val Phe Gly Ser 
        195                 200                 205             


Tyr Leu Asp Pro Leu Val Lys Gln Ala Phe Gln Ala Thr Ala Arg Ala 
    210                 215                 220                 


Asn Val Tyr Val Thr Glu Asn Ala Asp Ile Ala Cys Leu Tyr Val Ile 
225                 230                 235                 240 


Leu Val Gly Glu Met Gln Glu Pro Val Val Leu Arg Pro Ala Glu Leu 
                245                 250                 255     


Glu Lys Gln Leu Tyr Ser Leu Pro His Trp Arg Thr Asp Gly His Asn 
            260                 265                 270         


His Val Ile Ile Asn Leu Ser Arg Lys Ser Asp Thr Gln Asn Leu Leu 
        275                 280                 285             


Tyr Asn Val Ser Thr Gly Arg Ala Met Val Ala Gln Ser Thr Phe Tyr 
    290                 295                 300                 


Thr Val Gln Tyr Arg Pro Gly Phe Asp Leu Val Val Ser Pro Leu Val 
305                 310                 315                 320 


His Ala Met Ser Glu Pro Asn Phe Met Glu Ile Pro Pro Gln Val Pro 
                325                 330                 335     


Val Lys Arg Lys Tyr Leu Phe Thr Phe Gln Gly Glu Lys Ile Glu Ser 
            340                 345                 350         


Leu Arg Ser Ser Leu Gln Glu Ala Arg Ser Phe Glu Glu Glu Met Glu 
        355                 360                 365             


Gly Asp Pro Pro Ala Asp Tyr Asp Asp Arg Ile Ile Ala Thr Leu Lys 
    370                 375                 380                 


Ala Val Gln Asp Ser Lys Leu Asp Gln Val Leu Val Glu Phe Thr Cys 
385                 390                 395                 400 


Lys Asn Gln Pro Lys Pro Ser Leu Pro Thr Glu Trp Ala Leu Cys Gly 
                405                 410                 415     


Glu Arg Glu Asp Arg Leu Glu Leu Leu Lys Leu Ser Thr Phe Ala Leu 
            420                 425                 430         


Ile Ile Thr Pro Gly Asp Pro Arg Leu Val Ile Ser Ser Gly Cys Ala 
        435                 440                 445             


Thr Arg Leu Phe Glu Ala Leu Glu Val Gly Ala Val Pro Val Val Leu 
    450                 455                 460                 


Gly Glu Gln Val Gln Leu Pro Tyr Gln Asp Met Leu Gln Trp Asn Glu 
465                 470                 475                 480 


Ala Ala Leu Val Val Pro Lys Pro Arg Val Thr Glu Val His Phe Leu 
                485                 490                 495     


Leu Arg Ser Leu Ser Asp Ser Asp Leu Leu Ala Met Arg Arg Gln Gly 
            500                 505                 510         


Arg Phe Leu Trp Glu Thr Tyr Phe Ser Thr Ala Asp Ser Ile Phe Asn 
        515                 520                 525             


Thr Val Leu Ala Met Ile Arg Thr Arg Ile Gln Ile Pro Ala Ala Pro 
    530                 535                 540                 


Ile Arg Glu Glu Ala Ala Ala Glu Ile Pro His Arg Ser Gly Lys Ala 
545                 550                 555                 560 


Ala Gly Thr Asp Pro Asn Met Ala Asp Asn Gly Asp Leu Asp Leu Gly 
                565                 570                 575     


Pro Val Glu Thr Glu Pro Pro Tyr Ala Ser Pro Arg Tyr Leu Arg Asn 
            580                 585                 590         


Phe Thr Leu Thr Val Thr Asp Phe Tyr Arg Ser Trp Asn Cys Ala Pro 
        595                 600                 605             


Gly Pro Phe His Leu Phe Pro His Thr Pro Phe Asp Pro Val Leu Pro 
    610                 615                 620                 


Ser Glu Ala Lys Phe Leu Gly Ser Gly Thr Gly Phe Arg Pro Ile Gly 
625                 630                 635                 640 


Gly Gly Ala Gly Gly Ser Gly Lys Glu Phe Gln Ala Ala Leu Gly Gly 
                645                 650                 655     


Asn Val Pro Arg Glu Gln Phe Thr Val Val Met Leu Thr Tyr Glu Arg 
            660                 665                 670         


Glu Glu Val Leu Met Asn Ser Leu Glu Arg Leu Asn Gly Leu Pro Tyr 
        675                 680                 685             


Leu Asn Lys Val Val Val Val Trp Asn Ser Pro Lys Leu Pro Ser Glu 
    690                 695                 700                 


Asp Leu Leu Trp Pro Asp Ile Gly Val Pro Ile Met Val Val Arg Thr 
705                 710                 715                 720 


Glu Lys Asn Ser Leu Asn Asn Arg Phe Leu Pro Trp Asn Glu Ile Glu 
                725                 730                 735     


Thr Glu Ala Ile Leu Ser Ile Asp Asp Asp Ala His Leu Arg His Asp 
            740                 745                 750         


Glu Ile Met Phe Gly Phe Arg Val Trp Arg Glu Ala Arg Asp Arg Ile 
        755                 760                 765             


Val Gly Phe Pro Gly Arg Tyr His Ala Trp Asp Ile Pro His Gln Ser 
    770                 775                 780                 


Trp Leu Tyr Asn Ser Asn Tyr Ser Cys Glu Leu Ser Met Val Leu Thr 
785                 790                 795                 800 


Gly Ala Ala Phe Phe His Lys Tyr Tyr Ala Tyr Leu Tyr Ser Tyr Val 
                805                 810                 815     


Met Pro Gln Ala Ile Arg Asp Met Val Asp Glu Tyr Ile Asn Cys Glu 
            820                 825                 830         


Asp Ile Ala Met Asn Phe Leu Val Ser His Ile Thr Arg Lys Pro Pro 
        835                 840                 845             


Ile Lys Val Thr Ser Arg Trp Thr Phe Arg Cys Pro Gly Cys Pro Gln 
    850                 855                 860                 


Ala Leu Ser His Asp Asp Ser His Phe His Glu Arg His Lys Cys Ile 
865                 870                 875                 880 


Asn Phe Phe Val Lys Val Tyr Gly Tyr Met Pro Leu Leu Tyr Thr Gln 
                885                 890                 895     


Phe Arg Val Asp Ser Val Leu Phe Lys Thr Arg Leu Pro His Asp Lys 
            900                 905                 910         


Thr Lys Cys Phe Lys Phe Ile 
        915                 


<210>  2375
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  2375

Met Val Gln Tyr Glu Leu Trp Ala Ala Leu Pro Gly Ala Ser Gly Val 
1               5                   10                  15      


Ala Leu Ala Cys Cys Phe Val Ala Ala Ala Val Ala Leu Arg Trp Ser 
            20                  25                  30          


Gly Arg Arg Thr Ala Arg Gly Ala Val Val Arg Ala Arg Gln Arg Gln 
        35                  40                  45              


Arg Ala Gly Leu Glu Asn Met Asp Arg Ala Ala Gln Arg Phe Arg Leu 
    50                  55                  60                  


Gln Asn Pro Asp Leu Asp Ser Glu Ala Leu Leu Ala Leu Pro Leu Pro 
65                  70                  75                  80  


Gln Leu Val Gln Lys Leu His Ser Arg Glu Leu Ala Pro Glu Ala Val 
                85                  90                  95      


Leu Phe Thr Tyr Val Gly Lys Ala Trp Glu Val Asn Lys Gly Thr Asn 
            100                 105                 110         


Cys Val Thr Ser Tyr Leu Ala Asp Cys Glu Thr Gln Leu Ser Gln Ala 
        115                 120                 125             


Pro Arg Gln Gly Leu Leu Tyr Gly Val Pro Val Ser Leu Lys Glu Cys 
    130                 135                 140                 


Phe Thr Tyr Lys Gly Gln Asp Ser Thr Leu Gly Leu Ser Leu Asn Glu 
145                 150                 155                 160 


Gly Val Pro Ala Glu Cys Asp Ser Val Val Val His Val Leu Lys Leu 
                165                 170                 175     


Gln Gly Ala Val Pro Phe Val His Thr Asn Val Pro Gln Ser Met Phe 
            180                 185                 190         


Ser Tyr Asp Cys Ser Asn Pro Leu Phe Gly Gln Thr Val Asn Pro Trp 
        195                 200                 205             


Lys Ser Ser Lys Ser Pro Gly Gly Ser Ser Gly Gly Glu Gly Ala Leu 
    210                 215                 220                 


Ile Gly Ser Gly Gly Ser Pro Leu Gly Leu Gly Thr Asp Ile Gly Gly 
225                 230                 235                 240 


Ser Ile Arg Phe Pro Ser Ser Phe Cys Gly Ile Cys Gly Leu Lys Pro 
                245                 250                 255     


Thr Gly Asn Arg Leu Ser Lys Ser Gly Leu Lys Gly Cys Val Tyr Gly 
            260                 265                 270         


Gln Glu Ala Val Arg Leu Ser Val Gly Pro Met Ala Arg Asp Val Glu 
        275                 280                 285             


Ser Leu Ala Leu Cys Leu Arg Ala Leu Leu Cys Glu Asp Met Phe Arg 
    290                 295                 300                 


Leu Asp Pro Thr Val Pro Pro Leu Pro Phe Arg Glu Glu Val Tyr Thr 
305                 310                 315                 320 


Ser Ser Gln Pro Leu Arg Val Gly Tyr Tyr Glu Thr Asp Asn Tyr Thr 
                325                 330                 335     


Met Pro Ser Pro Ala Met Arg Arg Ala Val Leu Glu Thr Lys Gln Ser 
            340                 345                 350         


Leu Glu Ala Ala Gly His Thr Leu Val Pro Phe Leu Pro Ser Asn Ile 
        355                 360                 365             


Pro His Ala Leu Glu Thr Leu Ser Thr Gly Gly Leu Phe Ser Asp Gly 
    370                 375                 380                 


Gly His Thr Phe Leu Gln Asn Phe Lys Gly Asp Phe Val Asp Pro Cys 
385                 390                 395                 400 


Leu Gly Asp Leu Val Ser Ile Leu Lys Leu Pro Gln Trp Leu Lys Gly 
                405                 410                 415     


Leu Leu Ala Phe Leu Val Lys Pro Leu Leu Pro Arg Leu Ser Ala Phe 
            420                 425                 430         


Leu Ser Asn Met Lys Ser Arg Ser Ala Gly Lys Leu Trp Glu Leu Gln 
        435                 440                 445             


His Glu Ile Glu Val Tyr Arg Lys Thr Val Ile Ala Gln Trp Arg Ala 
    450                 455                 460                 


Leu Asp Leu Asp Val Val Leu Thr Pro Met Leu Ala Pro Ala Leu Asp 
465                 470                 475                 480 


Leu Asn Ala Pro Gly Arg Ala Thr Gly Ala Val Ser Tyr Thr Met Leu 
                485                 490                 495     


Tyr Asn Cys Leu Asp Phe Pro Ala Gly Val Val Pro Val Thr Thr Val 
            500                 505                 510         


Thr Ala Glu Asp Glu Ala Gln Met Glu His Tyr Arg Gly Tyr Phe Gly 
        515                 520                 525             


Asp Ile Trp Asp Lys Met Leu Gln Lys Gly Met Lys Lys Ser Val Gly 
    530                 535                 540                 


Leu Pro Val Ala Val Gln Cys Val Ala Leu Pro Trp Gln Glu Glu Leu 
545                 550                 555                 560 


Cys Leu Arg Phe Met Arg Glu Val Glu Arg Leu Met Thr Pro Glu Lys 
                565                 570                 575     


Gln Ser Ser 
            


<210>  2376
<211>  4349
<212>  PRT
<213>  Homo sapiens

<400>  2376

Met Thr Ile Ala Leu Leu Gly Phe Ala Ile Phe Leu Leu His Cys Ala 
1               5                   10                  15      


Thr Cys Glu Lys Pro Leu Glu Gly Ile Leu Ser Ser Ser Ala Trp His 
            20                  25                  30          


Phe Thr His Ser His Tyr Asn Ala Thr Ile Tyr Glu Asn Ser Ser Pro 
        35                  40                  45              


Lys Thr Tyr Val Glu Ser Phe Glu Lys Met Gly Ile Tyr Leu Ala Glu 
    50                  55                  60                  


Pro Gln Trp Ala Val Arg Tyr Arg Ile Ile Ser Gly Asp Val Ala Asn 
65                  70                  75                  80  


Val Phe Lys Thr Glu Glu Tyr Val Val Gly Asn Phe Cys Phe Leu Arg 
                85                  90                  95      


Ile Arg Thr Lys Ser Ser Asn Thr Ala Leu Leu Asn Arg Glu Val Arg 
            100                 105                 110         


Asp Ser Tyr Thr Leu Ile Ile Gln Ala Thr Glu Lys Thr Leu Glu Leu 
        115                 120                 125             


Glu Ala Leu Thr Arg Val Val Val His Ile Leu Asp Gln Asn Asp Leu 
    130                 135                 140                 


Lys Pro Leu Phe Ser Pro Pro Ser Tyr Arg Val Thr Ile Ser Glu Asp 
145                 150                 155                 160 


Met Pro Leu Lys Ser Pro Ile Cys Lys Val Thr Ala Thr Asp Ala Asp 
                165                 170                 175     


Leu Gly Gln Asn Ala Glu Phe Tyr Tyr Ala Phe Asn Thr Arg Ser Glu 
            180                 185                 190         


Met Phe Ala Ile His Pro Thr Ser Gly Val Val Thr Val Ala Gly Lys 
        195                 200                 205             


Leu Asn Val Thr Trp Arg Gly Lys His Glu Leu Gln Val Leu Ala Val 
    210                 215                 220                 


Asp Arg Met Arg Lys Ile Ser Glu Gly Asn Gly Phe Gly Ser Leu Ala 
225                 230                 235                 240 


Ala Leu Val Val His Val Glu Pro Ala Leu Arg Lys Pro Pro Ala Ile 
                245                 250                 255     


Ala Ser Val Val Val Thr Pro Pro Asp Ser Asn Asp Gly Thr Thr Tyr 
            260                 265                 270         


Ala Thr Val Leu Val Asp Ala Asn Ser Ser Gly Ala Glu Val Glu Ser 
        275                 280                 285             


Val Glu Val Val Gly Gly Asp Pro Gly Lys His Phe Lys Ala Ile Lys 
    290                 295                 300                 


Ser Tyr Ala Arg Ser Asn Glu Phe Ser Leu Val Ser Val Lys Asp Ile 
305                 310                 315                 320 


Asn Trp Met Glu Tyr Leu His Gly Phe Asn Leu Ser Leu Gln Ala Arg 
                325                 330                 335     


Ser Gly Ser Gly Pro Tyr Phe Tyr Ser Gln Ile Arg Gly Phe His Leu 
            340                 345                 350         


Pro Pro Ser Lys Leu Ser Ser Leu Lys Phe Glu Lys Ala Val Tyr Arg 
        355                 360                 365             


Val Gln Leu Ser Glu Phe Ser Pro Pro Gly Ser Arg Val Val Met Val 
    370                 375                 380                 


Arg Val Thr Pro Ala Phe Pro Asn Leu Gln Tyr Val Leu Lys Pro Ser 
385                 390                 395                 400 


Ser Glu Asn Val Gly Phe Lys Leu Asn Ala Arg Thr Gly Leu Ile Thr 
                405                 410                 415     


Thr Thr Lys Leu Met Asp Phe His Asp Arg Ala His Tyr Gln Leu His 
            420                 425                 430         


Ile Arg Thr Ser Pro Gly Gln Ala Ser Thr Val Val Val Ile Asp Ile 
        435                 440                 445             


Val Asp Cys Asn Asn His Ala Pro Leu Phe Asn Arg Ser Ser Tyr Asp 
    450                 455                 460                 


Gly Thr Leu Asp Glu Asn Ile Pro Pro Gly Thr Ser Val Leu Ala Val 
465                 470                 475                 480 


Thr Ala Thr Asp Arg Asp His Gly Glu Asn Gly Tyr Val Thr Tyr Ser 
                485                 490                 495     


Ile Ala Gly Pro Lys Ala Leu Pro Phe Ser Ile Asp Pro Tyr Leu Gly 
            500                 505                 510         


Ile Ile Ser Thr Ser Lys Pro Met Asp Tyr Glu Leu Met Lys Arg Ile 
        515                 520                 525             


Tyr Thr Phe Arg Val Arg Ala Ser Asp Trp Gly Ser Pro Phe Arg Arg 
    530                 535                 540                 


Glu Lys Glu Val Ser Ile Phe Leu Gln Leu Arg Asn Leu Asn Asp Asn 
545                 550                 555                 560 


Gln Pro Met Phe Glu Glu Val Asn Cys Thr Gly Ser Ile Arg Gln Asp 
                565                 570                 575     


Trp Pro Val Gly Lys Ser Ile Met Thr Met Ser Ala Ile Asp Val Asp 
            580                 585                 590         


Glu Leu Gln Asn Leu Lys Tyr Glu Ile Val Ser Gly Asn Glu Leu Glu 
        595                 600                 605             


Tyr Phe Asp Leu Asn His Phe Ser Gly Val Ile Ser Leu Lys Arg Pro 
    610                 615                 620                 


Phe Ile Asn Leu Thr Ala Gly Gln Pro Thr Ser Tyr Ser Leu Lys Ile 
625                 630                 635                 640 


Thr Ala Ser Asp Gly Lys Asn Tyr Ala Ser Pro Thr Thr Leu Asn Ile 
                645                 650                 655     


Thr Val Val Lys Asp Pro His Phe Glu Val Pro Val Thr Cys Asp Lys 
            660                 665                 670         


Thr Gly Val Leu Thr Gln Phe Thr Lys Thr Ile Leu His Phe Ile Gly 
        675                 680                 685             


Leu Gln Asn Gln Glu Ser Ser Asp Glu Glu Phe Thr Ser Leu Ser Thr 
    690                 695                 700                 


Tyr Gln Ile Asn His Tyr Thr Pro Gln Phe Glu Asp His Phe Pro Gln 
705                 710                 715                 720 


Ser Ile Asp Val Leu Glu Ser Val Pro Ile Asn Thr Pro Leu Ala Arg 
                725                 730                 735     


Leu Ala Ala Thr Asp Pro Asp Ala Gly Phe Asn Gly Lys Leu Val Tyr 
            740                 745                 750         


Val Ile Ala Asp Gly Asn Glu Glu Gly Cys Phe Asp Ile Glu Leu Glu 
        755                 760                 765             


Thr Gly Leu Leu Thr Val Ala Ala Pro Leu Asp Tyr Glu Ala Thr Asn 
    770                 775                 780                 


Phe Tyr Ile Leu Asn Val Thr Val Tyr Asp Leu Gly Thr Pro Gln Lys 
785                 790                 795                 800 


Ser Ser Trp Lys Leu Leu Thr Val Asn Val Lys Asp Trp Asn Asp Asn 
                805                 810                 815     


Ala Pro Arg Phe Pro Pro Gly Gly Tyr Gln Leu Thr Ile Ser Glu Asp 
            820                 825                 830         


Thr Glu Val Gly Thr Thr Ile Ala Glu Leu Thr Thr Lys Asp Ala Asp 
        835                 840                 845             


Ser Glu Asp Asn Gly Arg Val Arg Tyr Thr Leu Leu Ser Pro Thr Glu 
    850                 855                 860                 


Lys Phe Ser Leu His Pro Leu Thr Gly Glu Leu Val Val Thr Gly His 
865                 870                 875                 880 


Leu Asp Arg Glu Ser Glu Pro Arg Tyr Ile Leu Lys Val Glu Ala Arg 
                885                 890                 895     


Asp Gln Pro Ser Lys Gly His Gln Leu Phe Ser Val Thr Asp Leu Ile 
            900                 905                 910         


Ile Thr Leu Glu Asp Val Asn Asp Asn Ser Pro Gln Cys Ile Thr Glu 
        915                 920                 925             


His Asn Arg Leu Lys Val Pro Glu Asp Leu Pro Pro Gly Thr Val Leu 
    930                 935                 940                 


Thr Phe Leu Asp Ala Ser Asp Pro Asp Leu Gly Pro Ala Gly Glu Val 
945                 950                 955                 960 


Arg Tyr Val Leu Met Asp Gly Ala His Gly Thr Phe Arg Val Asp Leu 
                965                 970                 975     


Met Thr Gly Ala Leu Ile Leu Glu Arg Glu Leu Asp Phe Glu Arg Arg 
            980                 985                 990         


Ala Gly Tyr Asn Leu Ser Leu Trp  Ala Ser Asp Gly Gly  Arg Pro Leu 
        995                 1000                 1005             


Ala Arg  Arg Thr Leu Cys His  Val Glu Val Ile Val  Leu Asp Val 
    1010                 1015                 1020             


Asn Glu  Asn Leu His Pro Pro  His Phe Ala Ser Phe  Val His Gln 
    1025                 1030                 1035             


Gly Gln  Val Gln Glu Asn Ser  Pro Ser Gly Thr Gln  Val Ile Val 
    1040                 1045                 1050             


Val Ala  Ala Gln Asp Asp Asp  Ser Gly Leu Asp Gly  Glu Leu Gln 
    1055                 1060                 1065             


Tyr Phe  Leu Arg Ala Gly Thr  Gly Leu Ala Ala Phe  Ser Ile Asn 
    1070                 1075                 1080             


Gln Asp  Thr Gly Met Ile Gln  Thr Leu Ala Pro Leu  Asp Arg Glu 
    1085                 1090                 1095             


Phe Ala  Ser Tyr Tyr Trp Leu  Thr Val Leu Ala Val  Asp Arg Gly 
    1100                 1105                 1110             


Ser Val  Pro Leu Ser Ser Val  Thr Glu Val Tyr Ile  Glu Val Thr 
    1115                 1120                 1125             


Asp Ala  Asn Asp Asn Pro Pro  Gln Met Ser Gln Ala  Val Phe Tyr 
    1130                 1135                 1140             


Pro Ser  Ile Gln Glu Asp Ala  Pro Val Gly Thr Ser  Val Leu Gln 
    1145                 1150                 1155             


Leu Asp  Ala Trp Asp Pro Asp  Ser Ser Ser Lys Gly  Lys Leu Thr 
    1160                 1165                 1170             


Phe Asn  Ile Thr Ser Gly Asn  Tyr Met Gly Phe Phe  Met Ile His 
    1175                 1180                 1185             


Pro Val  Thr Gly Leu Leu Ser  Thr Ala Gln Gln Leu  Asp Arg Glu 
    1190                 1195                 1200             


Asn Lys  Asp Glu His Ile Leu  Glu Val Thr Val Leu  Asp Asn Gly 
    1205                 1210                 1215             


Glu Pro  Ser Leu Lys Ser Thr  Ser Arg Val Val Val  Gly Ile Leu 
    1220                 1225                 1230             


Asp Val  Asn Asp Asn Pro Pro  Ile Phe Ser His Lys  Leu Phe Asn 
    1235                 1240                 1245             


Val Arg  Leu Pro Glu Arg Leu  Ser Pro Val Ser Pro  Gly Pro Val 
    1250                 1255                 1260             


Tyr Arg  Leu Val Ala Ser Asp  Leu Asp Glu Gly Leu  Asn Gly Arg 
    1265                 1270                 1275             


Val Thr  Tyr Ser Ile Glu Asp  Ser Asp Glu Glu Ala  Phe Ser Ile 
    1280                 1285                 1290             


Asp Leu  Val Thr Gly Val Val  Ser Ser Ser Ser Thr  Phe Thr Ala 
    1295                 1300                 1305             


Gly Glu  Tyr Asn Ile Leu Thr  Ile Lys Ala Thr Asp  Ser Gly Gln 
    1310                 1315                 1320             


Pro Pro  Leu Ser Ala Ser Val  Arg Leu His Ile Glu  Trp Ile Pro 
    1325                 1330                 1335             


Trp Pro  Arg Pro Ser Ser Ile  Pro Leu Ala Phe Asp  Glu Thr Tyr 
    1340                 1345                 1350             


Tyr Ser  Phe Thr Val Met Glu  Thr Asp Pro Val Asn  His Met Val 
    1355                 1360                 1365             


Gly Val  Ile Ser Val Glu Gly  Arg Pro Gly Leu Phe  Trp Phe Asn 
    1370                 1375                 1380             


Ile Ser  Gly Gly Asp Lys Asp  Met Asp Phe Asp Ile  Glu Lys Thr 
    1385                 1390                 1395             


Thr Gly  Ser Ile Val Ile Ala  Arg Pro Leu Asp Thr  Arg Arg Arg 
    1400                 1405                 1410             


Ser Asn  Tyr Asn Leu Thr Val  Glu Val Thr Asp Gly  Ser Arg Thr 
    1415                 1420                 1425             


Ile Ala  Thr Gln Val His Ile  Phe Met Ile Ala Asn  Ile Asn His 
    1430                 1435                 1440             


His Arg  Pro Gln Phe Leu Glu  Thr Arg Tyr Glu Val  Arg Val Pro 
    1445                 1450                 1455             


Gln Asp  Thr Val Pro Gly Val  Glu Leu Leu Arg Val  Gln Ala Ile 
    1460                 1465                 1470             


Asp Gln  Asp Lys Gly Lys Ser  Leu Ile Tyr Thr Ile  His Gly Ser 
    1475                 1480                 1485             


Gln Asp  Pro Gly Ser Ala Ser  Leu Phe Gln Leu Asp  Pro Ser Ser 
    1490                 1495                 1500             


Gly Val  Leu Val Thr Val Gly  Lys Leu Asp Leu Gly  Ser Gly Pro 
    1505                 1510                 1515             


Ser Gln  His Thr Leu Thr Val  Met Val Arg Asp Gln  Glu Ile Pro 
    1520                 1525                 1530             


Ile Lys  Arg Asn Phe Val Trp  Val Thr Ile His Val  Glu Asp Gly 
    1535                 1540                 1545             


Asn Leu  His Pro Pro Arg Phe  Thr Gln Leu His Tyr  Glu Ala Ser 
    1550                 1555                 1560             


Val Pro  Asp Thr Ile Ala Pro  Gly Thr Glu Leu Leu  Gln Val Arg 
    1565                 1570                 1575             


Ala Met  Asp Ala Asp Arg Gly  Val Asn Ala Glu Val  His Tyr Ser 
    1580                 1585                 1590             


Leu Leu  Lys Gly Asn Ser Glu  Gly Phe Phe Asn Ile  Asn Ala Leu 
    1595                 1600                 1605             


Leu Gly  Ile Ile Thr Leu Ala  Gln Lys Leu Asp Gln  Ala Asn His 
    1610                 1615                 1620             


Ala Pro  His Thr Leu Thr Val  Lys Ala Glu Asp Gln  Gly Ser Pro 
    1625                 1630                 1635             


Gln Trp  His Asp Leu Ala Thr  Val Ile Ile His Val  Tyr Pro Ser 
    1640                 1645                 1650             


Asp Arg  Ser Ala Pro Ile Phe  Ser Lys Ser Glu Tyr  Phe Val Glu 
    1655                 1660                 1665             


Ile Pro  Glu Ser Ile Pro Val  Gly Ser Pro Ile Leu  Leu Val Ser 
    1670                 1675                 1680             


Ala Met  Ser Pro Ser Glu Val  Thr Tyr Glu Leu Arg  Glu Gly Asn 
    1685                 1690                 1695             


Lys Asp  Gly Val Phe Ser Met  Asn Ser Tyr Ser Gly  Leu Ile Ser 
    1700                 1705                 1710             


Thr Gln  Lys Lys Leu Asp His  Glu Lys Ile Ser Ser  Tyr Gln Leu 
    1715                 1720                 1725             


Lys Ile  Arg Gly Ser Asn Met  Ala Gly Ala Phe Thr  Asp Val Met 
    1730                 1735                 1740             


Val Val  Val Asp Ile Ile Asp  Glu Asn Asp Asn Ala  Pro Met Phe 
    1745                 1750                 1755             


Leu Lys  Ser Thr Phe Val Gly  Gln Ile Ser Glu Ala  Ala Pro Leu 
    1760                 1765                 1770             


Tyr Ser  Met Ile Met Asp Lys  Asn Asn Asn Pro Phe  Val Ile His 
    1775                 1780                 1785             


Ala Ser  Asp Ser Asp Lys Glu  Ala Asn Ser Leu Leu  Val Tyr Lys 
    1790                 1795                 1800             


Ile Leu  Glu Pro Glu Ala Leu  Lys Phe Phe Lys Ile  Asp Pro Ser 
    1805                 1810                 1815             


Met Gly  Thr Leu Thr Ile Val  Ser Glu Met Asp Tyr  Glu Ser Met 
    1820                 1825                 1830             


Pro Ser  Phe Gln Phe Cys Val  Tyr Val His Asp Gln  Gly Ser Pro 
    1835                 1840                 1845             


Val Leu  Phe Ala Pro Arg Pro  Ala Gln Val Ile Ile  His Val Arg 
    1850                 1855                 1860             


Asp Val  Asn Asp Ser Pro Pro  Arg Phe Ser Glu Gln  Ile Tyr Glu 
    1865                 1870                 1875             


Val Ala  Ile Val Gly Pro Ile  His Pro Gly Met Glu  Leu Leu Met 
    1880                 1885                 1890             


Val Arg  Ala Ser Asp Glu Asp  Ser Glu Val Asn Tyr  Ser Ile Lys 
    1895                 1900                 1905             


Thr Gly  Asn Ala Asp Glu Ala  Val Thr Ile His Pro  Val Thr Gly 
    1910                 1915                 1920             


Ser Ile  Ser Val Leu Asn Pro  Ala Phe Leu Gly Leu  Ser Arg Lys 
    1925                 1930                 1935             


Leu Thr  Ile Arg Ala Ser Asp  Gly Leu Tyr Gln Asp  Thr Ala Leu 
    1940                 1945                 1950             


Val Lys  Ile Ser Leu Thr Gln  Val Leu Asp Lys Ser  Leu Gln Phe 
    1955                 1960                 1965             


Asp Gln  Asp Val Tyr Trp Ala  Ala Val Lys Glu Asn  Leu Gln Asp 
    1970                 1975                 1980             


Arg Lys  Ala Leu Val Ile Leu  Gly Ala Gln Gly Asn  His Leu Asn 
    1985                 1990                 1995             


Asp Thr  Leu Ser Tyr Phe Leu  Leu Asn Gly Thr Asp  Met Phe His 
    2000                 2005                 2010             


Met Val  Gln Ser Ala Gly Val  Leu Gln Thr Arg Gly  Val Ala Phe 
    2015                 2020                 2025             


Asp Arg  Glu Gln Gln Asp Thr  His Glu Leu Ala Val  Glu Val Arg 
    2030                 2035                 2040             


Asp Asn  Arg Thr Pro Gln Arg  Val Ala Gln Gly Leu  Val Arg Val 
    2045                 2050                 2055             


Ser Ile  Glu Asp Val Asn Asp  Asn Pro Pro Lys Phe  Lys His Leu 
    2060                 2065                 2070             


Pro Tyr  Tyr Thr Ile Ile Gln  Asp Gly Thr Glu Pro  Gly Asp Val 
    2075                 2080                 2085             


Leu Phe  Gln Val Ser Ala Thr  Asp Glu Asp Leu Gly  Thr Asn Gly 
    2090                 2095                 2100             


Ala Val  Thr Tyr Glu Phe Ala  Glu Asp Tyr Thr Tyr  Phe Arg Ile 
    2105                 2110                 2115             


Asp Pro  Tyr Leu Gly Asp Ile  Ser Leu Lys Lys Pro  Phe Asp Tyr 
    2120                 2125                 2130             


Gln Ala  Leu Asn Lys Tyr His  Leu Lys Val Ile Ala  Arg Asp Gly 
    2135                 2140                 2145             


Gly Thr  Pro Ser Leu Gln Ser  Glu Glu Glu Val Leu  Val Thr Val 
    2150                 2155                 2160             


Arg Asn  Lys Ser Asn Pro Leu  Phe Gln Ser Pro Tyr  Tyr Lys Val 
    2165                 2170                 2175             


Arg Val  Pro Glu Asn Ile Thr  Leu Tyr Thr Pro Ile  Leu His Thr 
    2180                 2185                 2190             


Gln Ala  Arg Ser Pro Glu Gly  Leu Arg Leu Ile Tyr  Asn Ile Val 
    2195                 2200                 2205             


Glu Glu  Glu Pro Leu Met Leu  Phe Thr Thr Asp Phe  Lys Thr Gly 
    2210                 2215                 2220             


Val Leu  Thr Val Thr Gly Pro  Leu Asp Tyr Glu Ser  Lys Thr Lys 
    2225                 2230                 2235             


His Val  Phe Thr Val Arg Ala  Thr Asp Thr Ala Leu  Gly Ser Phe 
    2240                 2245                 2250             


Ser Glu  Ala Thr Val Glu Val  Leu Val Glu Asp Val  Asn Asp Asn 
    2255                 2260                 2265             


Pro Pro  Thr Phe Ser Gln Leu  Val Tyr Thr Thr Ser  Ile Ser Glu 
    2270                 2275                 2280             


Gly Leu  Pro Ala Gln Thr Pro  Val Ile Gln Leu Leu  Ala Ser Asp 
    2285                 2290                 2295             


Gln Asp  Ser Gly Arg Asn Arg  Asp Val Ser Tyr Gln  Ile Val Glu 
    2300                 2305                 2310             


Asp Gly  Ser Asp Val Ser Lys  Phe Phe Gln Ile Asn  Gly Ser Thr 
    2315                 2320                 2325             


Gly Glu  Met Ser Thr Val Gln  Glu Leu Asp Tyr Glu  Ala Gln Gln 
    2330                 2335                 2340             


His Phe  His Val Lys Val Arg  Ala Met Asp Lys Gly  Asp Pro Pro 
    2345                 2350                 2355             


Leu Thr  Gly Glu Thr Leu Val  Val Val Asn Val Ser  Asp Ile Asn 
    2360                 2365                 2370             


Asp Asn  Pro Pro Glu Phe Arg  Gln Pro Gln Tyr Glu  Ala Asn Val 
    2375                 2380                 2385             


Ser Glu  Leu Ala Thr Cys Gly  His Leu Val Leu Lys  Val Gln Ala 
    2390                 2395                 2400             


Ile Asp  Pro Asp Ser Arg Asp  Thr Ser Arg Leu Glu  Tyr Leu Ile 
    2405                 2410                 2415             


Leu Ser  Gly Asn Gln Asp Arg  His Phe Phe Ile Asn  Ser Ser Ser 
    2420                 2425                 2430             


Gly Ile  Ile Ser Met Phe Asn  Leu Cys Lys Lys His  Leu Asp Ser 
    2435                 2440                 2445             


Ser Tyr  Asn Leu Arg Val Gly  Ala Ser Asp Gly Val  Phe Arg Ala 
    2450                 2455                 2460             


Thr Val  Pro Val Tyr Ile Asn  Thr Thr Asn Ala Asn  Lys Tyr Ser 
    2465                 2470                 2475             


Pro Glu  Phe Gln Gln His Leu  Tyr Glu Ala Glu Leu  Ala Glu Asn 
    2480                 2485                 2490             


Ala Met  Val Gly Thr Lys Val  Ile Asp Leu Leu Ala  Ile Asp Lys 
    2495                 2500                 2505             


Asp Ser  Gly Pro Tyr Gly Thr  Ile Asp Tyr Thr Ile  Ile Asn Lys 
    2510                 2515                 2520             


Leu Ala  Ser Glu Lys Phe Ser  Ile Asn Pro Asn Gly  Gln Ile Ala 
    2525                 2530                 2535             


Thr Leu  Gln Lys Leu Asp Arg  Glu Asn Ser Thr Glu  Arg Val Ile 
    2540                 2545                 2550             


Ala Ile  Lys Val Met Ala Arg  Asp Gly Gly Gly Arg  Val Ala Phe 
    2555                 2560                 2565             


Cys Thr  Val Lys Ile Ile Leu  Thr Asp Glu Asn Asp  Asn Pro Pro 
    2570                 2575                 2580             


Gln Phe  Lys Ala Ser Glu Tyr  Thr Val Ser Ile Gln  Ser Asn Val 
    2585                 2590                 2595             


Ser Lys  Asp Ser Pro Val Ile  Gln Val Leu Ala Tyr  Asp Ala Asp 
    2600                 2605                 2610             


Glu Gly  Gln Asn Ala Asp Val  Thr Tyr Ser Val Asn  Pro Glu Asp 
    2615                 2620                 2625             


Leu Val  Lys Asp Val Ile Glu  Ile Asn Pro Val Thr  Gly Val Val 
    2630                 2635                 2640             


Lys Val  Lys Asp Ser Leu Val  Gly Leu Glu Asn Gln  Thr Leu Asp 
    2645                 2650                 2655             


Phe Phe  Ile Lys Ala Gln Asp  Gly Gly Pro Pro His  Trp Asn Ser 
    2660                 2665                 2670             


Leu Val  Pro Val Arg Leu Gln  Val Val Pro Lys Lys  Val Ser Leu 
    2675                 2680                 2685             


Pro Lys  Phe Ser Glu Pro Leu  Tyr Thr Phe Ser Ala  Pro Glu Asp 
    2690                 2695                 2700             


Leu Pro  Glu Gly Ser Glu Ile  Gly Ile Val Lys Ala  Val Ala Ala 
    2705                 2710                 2715             


Gln Asp  Pro Val Ile Tyr Ser  Leu Val Arg Gly Thr  Thr Pro Glu 
    2720                 2725                 2730             


Ser Asn  Lys Asp Gly Val Phe  Ser Leu Asp Pro Asp  Thr Gly Val 
    2735                 2740                 2745             


Ile Lys  Val Arg Lys Pro Met  Asp His Glu Ser Thr  Lys Leu Tyr 
    2750                 2755                 2760             


Gln Ile  Asp Val Met Ala His  Cys Leu Gln Asn Thr  Asp Val Val 
    2765                 2770                 2775             


Ser Leu  Val Ser Val Asn Ile  Gln Val Gly Asp Val  Asn Asp Asn 
    2780                 2785                 2790             


Arg Pro  Val Phe Glu Ala Asp  Pro Tyr Lys Ala Val  Leu Thr Glu 
    2795                 2800                 2805             


Asn Met  Pro Val Gly Thr Ser  Val Ile Gln Val Thr  Ala Ile Asp 
    2810                 2815                 2820             


Lys Asp  Thr Gly Arg Asp Gly  Gln Val Ser Tyr Arg  Leu Ser Ala 
    2825                 2830                 2835             


Asp Pro  Gly Ser Asn Val His  Glu Leu Phe Ala Ile  Asp Ser Glu 
    2840                 2845                 2850             


Ser Gly  Trp Ile Thr Thr Leu  Gln Glu Leu Asp Cys  Glu Thr Cys 
    2855                 2860                 2865             


Gln Thr  Tyr His Phe His Val  Val Ala Tyr Asp His  Gly Gln Thr 
    2870                 2875                 2880             


Ile Gln  Leu Ser Ser Gln Ala  Leu Val Gln Val Ser  Ile Thr Asp 
    2885                 2890                 2895             


Glu Asn  Asp Asn Ala Pro Arg  Phe Ala Ser Glu Glu  Tyr Arg Gly 
    2900                 2905                 2910             


Ser Val  Val Glu Asn Ser Glu  Pro Gly Glu Leu Val  Ala Thr Leu 
    2915                 2920                 2925             


Lys Thr  Leu Asp Ala Asp Ile  Ser Glu Gln Asn Arg  Gln Val Thr 
    2930                 2935                 2940             


Cys Tyr  Ile Thr Glu Gly Asp  Pro Leu Gly Gln Phe  Gly Ile Ser 
    2945                 2950                 2955             


Gln Val  Gly Asp Glu Trp Arg  Ile Ser Ser Arg Lys  Thr Leu Asp 
    2960                 2965                 2970             


Arg Glu  His Thr Ala Lys Tyr  Leu Leu Arg Val Thr  Ala Ser Asp 
    2975                 2980                 2985             


Gly Lys  Phe Gln Ala Ser Val  Thr Val Glu Ile Phe  Val Leu Asp 
    2990                 2995                 3000             


Val Asn  Asp Asn Ser Pro Gln  Cys Ser Gln Leu Leu  Tyr Thr Gly 
    3005                 3010                 3015             


Lys Val  His Glu Asp Val Phe  Pro Gly His Phe Ile  Leu Lys Val 
    3020                 3025                 3030             


Ser Ala  Thr Asp Leu Asp Thr  Asp Thr Asn Ala Gln  Ile Thr Tyr 
    3035                 3040                 3045             


Ser Leu  His Gly Pro Gly Ala  His Glu Phe Lys Leu  Asp Pro His 
    3050                 3055                 3060             


Thr Gly  Glu Leu Thr Thr Leu  Thr Ala Leu Asp Arg  Glu Arg Lys 
    3065                 3070                 3075             


Asp Val  Phe Asn Leu Val Ala  Lys Ala Thr Asp Gly  Gly Gly Arg 
    3080                 3085                 3090             


Ser Cys  Gln Ala Asp Ile Thr  Leu His Val Glu Asp  Val Asn Asp 
    3095                 3100                 3105             


Asn Ala  Pro Arg Phe Phe Pro  Ser His Cys Ala Val  Ala Val Phe 
    3110                 3115                 3120             


Asp Asn  Thr Thr Val Lys Thr  Pro Val Ala Val Val  Phe Ala Arg 
    3125                 3130                 3135             


Asp Pro  Asp Gln Gly Ala Asn  Ala Gln Val Val Tyr  Ser Leu Pro 
    3140                 3145                 3150             


Asp Ser  Ala Glu Gly His Phe  Ser Ile Asp Ala Thr  Thr Gly Val 
    3155                 3160                 3165             


Ile Arg  Leu Glu Lys Pro Leu  Gln Val Arg Pro Gln  Ala Pro Leu 
    3170                 3175                 3180             


Glu Leu  Thr Val Arg Ala Ser  Asp Leu Gly Thr Pro  Ile Pro Leu 
    3185                 3190                 3195             


Ser Thr  Leu Gly Thr Val Thr  Val Ser Val Val Gly  Leu Glu Asp 
    3200                 3205                 3210             


Tyr Leu  Pro Val Phe Leu Asn  Thr Glu His Ser Val  Gln Val Pro 
    3215                 3220                 3225             


Glu Asp  Ala Pro Pro Gly Thr  Glu Val Leu Gln Leu  Ala Thr Leu 
    3230                 3235                 3240             


Thr Arg  Pro Gly Ala Glu Lys  Thr Gly Tyr Arg Val  Val Ser Gly 
    3245                 3250                 3255             


Asn Glu  Gln Gly Arg Phe Arg  Leu Asp Ala Arg Thr  Gly Ile Leu 
    3260                 3265                 3270             


Tyr Val  Asn Ala Ser Leu Asp  Phe Glu Thr Ser Pro  Lys Tyr Phe 
    3275                 3280                 3285             


Leu Ser  Ile Glu Cys Ser Arg  Lys Ser Ser Ser Ser  Leu Ser Asp 
    3290                 3295                 3300             


Val Thr  Thr Val Met Val Asn  Ile Thr Asp Val Asn  Glu His Arg 
    3305                 3310                 3315             


Pro Gln  Phe Pro Gln Asp Pro  Tyr Ser Thr Arg Val  Leu Glu Asn 
    3320                 3325                 3330             


Ala Leu  Val Gly Asp Val Ile  Leu Thr Val Ser Ala  Thr Asp Glu 
    3335                 3340                 3345             


Asp Gly  Pro Leu Asn Ser Asp  Ile Thr Tyr Ser Leu  Ile Gly Gly 
    3350                 3355                 3360             


Asn Gln  Leu Gly His Phe Thr  Ile His Pro Lys Lys  Gly Glu Leu 
    3365                 3370                 3375             


Gln Val  Ala Lys Ala Leu Asp  Arg Glu Gln Ala Ser  Ser Tyr Ser 
    3380                 3385                 3390             


Leu Lys  Leu Arg Ala Thr Asp  Ser Gly Gln Pro Pro  Leu His Glu 
    3395                 3400                 3405             


Asp Thr  Asp Ile Ala Ile Gln  Val Ala Asp Val Asn  Asp Asn Pro 
    3410                 3415                 3420             


Pro Arg  Phe Phe Gln Leu Asn  Tyr Ser Thr Thr Val  Gln Glu Asn 
    3425                 3430                 3435             


Ser Pro  Ile Gly Ser Lys Val  Leu Gln Leu Ile Leu  Ser Asp Pro 
    3440                 3445                 3450             


Asp Ser  Pro Glu Asn Gly Pro  Pro Tyr Ser Phe Arg  Ile Thr Lys 
    3455                 3460                 3465             


Gly Asn  Asn Gly Ser Ala Phe  Arg Val Thr Pro Asp  Gly Trp Leu 
    3470                 3475                 3480             


Val Thr  Ala Glu Gly Leu Ser  Arg Arg Ala Gln Glu  Trp Tyr Gln 
    3485                 3490                 3495             


Leu Gln  Ile Gln Ala Ser Asp  Ser Gly Ile Pro Pro  Leu Ser Ser 
    3500                 3505                 3510             


Leu Thr  Ser Val Arg Val His  Val Thr Glu Gln Ser  His Tyr Ala 
    3515                 3520                 3525             


Pro Ser  Ala Leu Pro Leu Glu  Ile Phe Ile Thr Val  Gly Glu Asp 
    3530                 3535                 3540             


Glu Phe  Gln Gly Gly Met Val  Gly Lys Ile His Ala  Thr Asp Arg 
    3545                 3550                 3555             


Asp Pro  Gln Asp Thr Leu Thr  Tyr Ser Leu Ala Glu  Glu Glu Thr 
    3560                 3565                 3570             


Leu Gly  Arg His Phe Ser Val  Gly Ala Pro Asp Gly  Lys Ile Ile 
    3575                 3580                 3585             


Ala Ala  Gln Gly Leu Pro Arg  Gly His Tyr Ser Phe  Asn Val Thr 
    3590                 3595                 3600             


Val Ser  Asp Gly Thr Phe Thr  Thr Thr Ala Gly Val  His Val Tyr 
    3605                 3610                 3615             


Val Trp  His Val Gly Gln Glu  Ala Leu Gln Gln Ala  Met Trp Met 
    3620                 3625                 3630             


Gly Phe  Tyr Gln Leu Thr Pro  Glu Glu Leu Val Ser  Asp His Trp 
    3635                 3640                 3645             


Arg Asn  Leu Gln Arg Phe Leu  Ser His Lys Leu Asp  Ile Lys Arg 
    3650                 3655                 3660             


Ala Asn  Ile His Leu Ala Ser  Leu Gln Pro Ala Glu  Ala Val Ala 
    3665                 3670                 3675             


Gly Val  Asp Val Leu Leu Val  Phe Glu Gly His Ser  Gly Thr Phe 
    3680                 3685                 3690             


Tyr Glu  Phe Gln Glu Leu Ala  Ser Ile Ile Thr His  Ser Ala Lys 
    3695                 3700                 3705             


Glu Met  Glu His Ser Val Gly  Val Gln Met Arg Ser  Ala Met Pro 
    3710                 3715                 3720             


Met Val  Pro Cys Gln Gly Pro  Thr Cys Gln Gly Gln  Ile Cys His 
    3725                 3730                 3735             


Asn Thr  Val His Leu Asp Pro  Lys Val Gly Pro Thr  Tyr Ser Thr 
    3740                 3745                 3750             


Ala Arg  Leu Ser Ile Leu Thr  Pro Arg His His Leu  Gln Arg Ser 
    3755                 3760                 3765             


Cys Ser  Cys Asn Gly Thr Ala  Thr Arg Phe Ser Gly  Gln Ser Tyr 
    3770                 3775                 3780             


Val Arg  Tyr Arg Ala Pro Ala  Ala Arg Asn Trp His  Ile His Phe 
    3785                 3790                 3795             


Tyr Leu  Lys Thr Leu Gln Pro  Gln Ala Ile Leu Leu  Phe Thr Asn 
    3800                 3805                 3810             


Glu Thr  Ala Ser Val Ser Leu  Lys Leu Ala Ser Gly  Val Pro Gln 
    3815                 3820                 3825             


Leu Glu  Tyr His Cys Leu Gly  Gly Phe Tyr Gly Asn  Leu Ser Ser 
    3830                 3835                 3840             


Gln Arg  His Val Asn Asp His  Glu Trp His Ser Ile  Leu Val Glu 
    3845                 3850                 3855             


Glu Met  Asp Ala Ser Ile Arg  Leu Met Val Asp Ser  Met Gly Asn 
    3860                 3865                 3870             


Thr Ser  Leu Val Val Pro Glu  Asn Cys Arg Gly Leu  Arg Pro Glu 
    3875                 3880                 3885             


Arg His  Leu Leu Leu Gly Gly  Leu Ile Leu Leu His  Ser Ser Ser 
    3890                 3895                 3900             


Asn Val  Ser Gln Gly Phe Glu  Gly Cys Leu Asp Ala  Val Val Val 
    3905                 3910                 3915             


Asn Glu  Glu Ala Leu Asp Leu  Leu Ala Pro Gly Lys  Thr Val Ala 
    3920                 3925                 3930             


Gly Leu  Leu Glu Thr Gln Ala  Leu Thr Gln Cys Cys  Leu His Ser 
    3935                 3940                 3945             


Asp Tyr  Cys Ser Gln Asn Thr  Cys Leu Asn Gly Gly  Lys Cys Ser 
    3950                 3955                 3960             


Trp Thr  His Gly Ala Gly Tyr  Val Cys Lys Cys Pro  Pro Gln Phe 
    3965                 3970                 3975             


Ser Gly  Lys His Cys Glu Gln  Gly Arg Glu Asn Cys  Thr Phe Ala 
    3980                 3985                 3990             


Pro Cys  Leu Glu Gly Gly Thr  Cys Ile Leu Ser Pro  Lys Gly Ala 
    3995                 4000                 4005             


Ser Cys  Asn Cys Pro His Pro  Tyr Thr Gly Asp Arg  Cys Glu Met 
    4010                 4015                 4020             


Glu Ala  Arg Gly Cys Ser Glu  Gly His Cys Leu Val  Thr Pro Glu 
    4025                 4030                 4035             


Ile Gln  Arg Gly Asp Trp Gly  Gln Gln Glu Leu Leu  Ile Ile Thr 
    4040                 4045                 4050             


Val Ala  Val Ala Phe Ile Ile  Ile Ser Thr Val Gly  Leu Leu Phe 
    4055                 4060                 4065             


Tyr Cys  Arg Arg Cys Lys Ser  His Lys Pro Val Ala  Met Glu Asp 
    4070                 4075                 4080             


Pro Asp  Leu Leu Ala Arg Ser  Val Gly Val Asp Thr  Gln Ala Met 
    4085                 4090                 4095             


Pro Ala  Ile Glu Leu Asn Pro  Leu Ser Ala Ser Ser  Cys Asn Asn 
    4100                 4105                 4110             


Leu Asn  Gln Pro Glu Pro Ser  Lys Ala Ser Val Pro  Asn Glu Leu 
    4115                 4120                 4125             


Val Thr  Phe Gly Pro Asn Ser  Lys Gln Arg Pro Val  Val Cys Ser 
    4130                 4135                 4140             


Val Pro  Pro Arg Leu Pro Pro  Ala Ala Val Pro Ser  His Ser Asp 
    4145                 4150                 4155             


Asn Glu  Pro Val Ile Lys Arg  Thr Trp Ser Ser Glu  Glu Met Val 
    4160                 4165                 4170             


Tyr Pro  Gly Gly Ala Met Val  Trp Pro Pro Thr Tyr  Ser Arg Asn 
    4175                 4180                 4185             


Glu Arg  Trp Glu Tyr Pro His  Ser Glu Val Thr Gln  Gly Pro Leu 
    4190                 4195                 4200             


Pro Pro  Ser Ala His Arg His  Ser Thr Pro Val Val  Met Pro Glu 
    4205                 4210                 4215             


Pro Asn  Gly Leu Tyr Gly Gly  Phe Pro Phe Pro Leu  Glu Met Glu 
    4220                 4225                 4230             


Asn Lys  Arg Ala Pro Leu Pro  Pro Arg Tyr Ser Asn  Gln Asn Leu 
    4235                 4240                 4245             


Glu Asp  Leu Met Pro Ser Arg  Pro Pro Ser Pro Arg  Glu Arg Leu 
    4250                 4255                 4260             


Val Ala  Pro Cys Leu Asn Glu  Tyr Thr Ala Ile Ser  Tyr Tyr His 
    4265                 4270                 4275             


Ser Gln  Phe Arg Gln Gly Gly  Gly Gly Pro Cys Leu  Ala Asp Gly 
    4280                 4285                 4290             


Gly Tyr  Lys Gly Val Gly Met  Arg Leu Ser Arg Ala  Gly Pro Ser 
    4295                 4300                 4305             


Tyr Ala  Val Cys Glu Val Glu  Gly Ala Pro Leu Ala  Gly Gln Gly 
    4310                 4315                 4320             


Gln Pro  Arg Val Pro Pro Asn  Tyr Glu Gly Ser Asp  Met Val Glu 
    4325                 4330                 4335             


Ser Asp  Tyr Gly Ser Cys Glu  Glu Val Met Phe 
    4340                 4345                 


<210>  2377
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  2377

Met Thr Val Leu Ala Pro Ala Trp Ser Pro Thr Thr Tyr Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ser Gly Leu Ser Gly Thr Gln Asp Cys Ser Phe 
            20                  25                  30          


Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 
        35                  40                  45              


Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 
    50                  55                  60                  


Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 
65                  70                  75                  80  


Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 
                85                  90                  95      


Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 
            100                 105                 110         


Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 
        115                 120                 125             


Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 
    130                 135                 140                 


Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala 
                165                 170                 175     


Thr Ala Pro Thr Ala Pro Gln Pro Pro Leu Leu Leu Leu Leu Leu Leu 
            180                 185                 190         


Pro Val Gly Leu Leu Leu Leu Ala Ala Ala Trp Cys Leu His Trp Gln 
        195                 200                 205             


Arg Thr Arg Arg Arg Thr Pro Arg Pro Gly Glu Gln Val Pro Pro Val 
    210                 215                 220                 


Pro Ser Pro Gln Asp Leu Leu Leu Val Glu His 
225                 230                 235 


<210>  2378
<211>  535
<212>  PRT
<213>  Homo sapiens

<400>  2378

Met Ala Lys Lys Val Ala Val Ile Gly Ala Gly Val Ser Gly Leu Ile 
1               5                   10                  15      


Ser Leu Lys Cys Cys Val Asp Glu Gly Leu Glu Pro Thr Cys Phe Glu 
            20                  25                  30          


Arg Thr Glu Asp Ile Gly Gly Val Trp Arg Phe Lys Glu Asn Val Glu 
        35                  40                  45              


Asp Gly Arg Ala Ser Ile Tyr Gln Ser Val Val Thr Asn Thr Ser Lys 
    50                  55                  60                  


Glu Met Ser Cys Phe Ser Asp Phe Pro Met Pro Glu Asp Phe Pro Asn 
65                  70                  75                  80  


Phe Leu His Asn Ser Lys Leu Leu Glu Tyr Phe Arg Ile Phe Ala Lys 
                85                  90                  95      


Lys Phe Asp Leu Leu Lys Tyr Ile Gln Phe Gln Thr Thr Val Leu Ser 
            100                 105                 110         


Val Arg Lys Cys Pro Asp Phe Ser Ser Ser Gly Gln Trp Lys Val Val 
        115                 120                 125             


Thr Gln Ser Asn Gly Lys Glu Gln Ser Ala Val Phe Asp Ala Val Met 
    130                 135                 140                 


Val Cys Ser Gly His His Ile Leu Pro His Ile Pro Leu Lys Ser Phe 
145                 150                 155                 160 


Pro Gly Met Glu Arg Phe Lys Gly Gln Tyr Phe His Ser Arg Gln Tyr 
                165                 170                 175     


Lys His Pro Asp Gly Phe Glu Gly Lys Arg Ile Leu Val Ile Gly Met 
            180                 185                 190         


Gly Asn Ser Gly Ser Asp Ile Ala Val Glu Leu Ser Lys Asn Ala Ala 
        195                 200                 205             


Gln Val Phe Ile Ser Thr Arg His Gly Thr Trp Val Met Ser Arg Ile 
    210                 215                 220                 


Ser Glu Asp Gly Tyr Pro Trp Asp Ser Val Phe His Thr Arg Phe Arg 
225                 230                 235                 240 


Ser Met Leu Arg Asn Val Leu Pro Arg Thr Ala Val Lys Trp Met Ile 
                245                 250                 255     


Glu Gln Gln Met Asn Arg Trp Phe Asn His Glu Asn Tyr Gly Leu Glu 
            260                 265                 270         


Pro Gln Asn Lys Tyr Ile Met Lys Glu Pro Val Leu Asn Asp Asp Val 
        275                 280                 285             


Pro Ser Arg Leu Leu Cys Gly Ala Ile Lys Val Lys Ser Thr Val Lys 
    290                 295                 300                 


Glu Leu Thr Glu Thr Ser Ala Ile Phe Glu Asp Gly Thr Val Glu Glu 
305                 310                 315                 320 


Asn Ile Asp Val Ile Ile Phe Ala Thr Gly Tyr Ser Phe Ser Phe Pro 
                325                 330                 335     


Phe Leu Glu Asp Ser Leu Val Lys Val Glu Asn Asn Met Val Ser Leu 
            340                 345                 350         


Tyr Lys Tyr Ile Phe Pro Ala His Leu Asp Lys Ser Thr Leu Ala Cys 
        355                 360                 365             


Ile Gly Leu Ile Gln Pro Leu Gly Ser Ile Phe Pro Thr Ala Glu Leu 
    370                 375                 380                 


Gln Ala Arg Trp Val Thr Arg Val Phe Lys Gly Leu Cys Ser Leu Pro 
385                 390                 395                 400 


Ser Glu Arg Thr Met Met Met Asp Ile Ile Lys Arg Asn Glu Lys Arg 
                405                 410                 415     


Ile Asp Leu Phe Gly Glu Ser Gln Ser Gln Thr Leu Gln Thr Asn Tyr 
            420                 425                 430         


Val Asp Tyr Leu Asp Glu Leu Ala Leu Glu Ile Gly Ala Lys Pro Asp 
        435                 440                 445             


Phe Cys Ser Leu Leu Phe Lys Asp Pro Lys Leu Ala Val Arg Leu Tyr 
    450                 455                 460                 


Phe Gly Pro Cys Asn Ser Tyr Gln Tyr Arg Leu Val Gly Pro Gly Gln 
465                 470                 475                 480 


Trp Glu Gly Ala Arg Asn Ala Ile Phe Thr Gln Lys Gln Arg Ile Leu 
                485                 490                 495     


Lys Pro Leu Lys Thr Arg Ala Leu Lys Asp Ser Ser Asn Phe Ser Val 
            500                 505                 510         


Ser Phe Leu Leu Lys Ile Leu Gly Leu Leu Ala Val Val Val Ala Phe 
        515                 520                 525             


Phe Cys Gln Leu Gln Trp Ser 
    530                 535 


<210>  2379
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  2379

Met Thr Lys Lys Arg Ile Ala Val Ile Gly Gly Gly Val Ser Gly Leu 
1               5                   10                  15      


Ser Ser Ile Lys Cys Cys Val Glu Glu Gly Leu Glu Pro Val Cys Phe 
            20                  25                  30          


Glu Arg Thr Asp Asp Ile Gly Gly Leu Trp Arg Phe Gln Glu Asn Pro 
        35                  40                  45              


Glu Glu Gly Arg Ala Ser Ile Tyr Lys Ser Val Ile Ile Asn Thr Ser 
    50                  55                  60                  


Lys Glu Met Met Cys Phe Ser Asp Tyr Pro Ile Pro Asp His Tyr Pro 
65                  70                  75                  80  


Asn Phe Met His Asn Ala Gln Val Leu Glu Tyr Phe Arg Met Tyr Ala 
                85                  90                  95      


Lys Glu Phe Asp Leu Leu Lys Tyr Ile Arg Phe Lys Thr Thr Val Cys 
            100                 105                 110         


Ser Val Lys Lys Gln Pro Asp Phe Ala Thr Ser Gly Gln Trp Glu Val 
        115                 120                 125             


Val Thr Glu Ser Glu Gly Lys Lys Glu Met Asn Val Phe Asp Gly Val 
    130                 135                 140                 


Met Val Cys Thr Gly His His Thr Asn Ala His Leu Pro Leu Glu Ser 
145                 150                 155                 160 


Phe Pro Gly Ile Glu Lys Phe Lys Gly Gln Tyr Phe His Ser Arg Asp 
                165                 170                 175     


Tyr Lys Asn Pro Glu Gly Phe Thr Gly Lys Arg Val Ile Ile Ile Gly 
            180                 185                 190         


Ile Gly Asn Ser Gly Gly Asp Leu Ala Val Glu Ile Ser Gln Thr Ala 
        195                 200                 205             


Lys Gln Val Phe Leu Ser Thr Arg Arg Gly Ala Trp Ile Leu Asn Arg 
    210                 215                 220                 


Val Gly Asp Tyr Gly Tyr Pro Ala Asp Val Leu Phe Ser Ser Arg Leu 
225                 230                 235                 240 


Thr His Phe Ile Trp Lys Ile Cys Gly Gln Ser Leu Ala Asn Lys Tyr 
                245                 250                 255     


Leu Glu Lys Lys Ile Asn Gln Arg Phe Asp His Glu Met Phe Gly Leu 
            260                 265                 270         


Lys Pro Lys His Arg Ala Leu Ser Gln His Pro Thr Leu Asn Asp Asp 
        275                 280                 285             


Leu Pro Asn Arg Ile Ile Ser Gly Leu Val Lys Val Lys Gly Asn Val 
    290                 295                 300                 


Lys Glu Phe Thr Glu Thr Ala Ala Ile Phe Glu Asp Gly Ser Arg Glu 
305                 310                 315                 320 


Asp Asp Ile Asp Ala Val Ile Phe Ala Thr Gly Tyr Ser Phe Asp Phe 
                325                 330                 335     


Pro Phe Leu Glu Asp Ser Val Lys Val Val Lys Asn Lys Ile Ser Leu 
            340                 345                 350         


Tyr Lys Lys Val Phe Pro Pro Asn Leu Glu Arg Pro Thr Leu Ala Ile 
        355                 360                 365             


Ile Gly Leu Ile Gln Pro Leu Gly Ala Ile Met Pro Ile Ser Glu Leu 
    370                 375                 380                 


Gln Gly Arg Trp Ala Thr Gln Val Phe Lys Gly Leu Lys Thr Leu Pro 
385                 390                 395                 400 


Ser Gln Ser Glu Met Met Ala Glu Ile Ser Lys Ala Gln Glu Glu Ile 
                405                 410                 415     


Asp Lys Arg Tyr Val Glu Ser Gln Arg His Thr Ile Gln Gly Asp Tyr 
            420                 425                 430         


Ile Asp Thr Met Glu Glu Leu Ala Asp Leu Val Gly Val Arg Pro Asn 
        435                 440                 445             


Leu Leu Ser Leu Ala Phe Thr Asp Pro Lys Leu Ala Leu His Leu Leu 
    450                 455                 460                 


Leu Gly Pro Cys Thr Pro Ile His Tyr Arg Val Gln Gly Pro Gly Lys 
465                 470                 475                 480 


Trp Asp Gly Ala Arg Lys Ala Ile Leu Thr Thr Asp Asp Arg Ile Arg 
                485                 490                 495     


Lys Pro Leu Met Thr Arg Val Val Glu Arg Ser Ser Ser Met Thr Ser 
            500                 505                 510         


Thr Met Thr Ile Gly Lys Phe Met Leu Ala Leu Ala Phe Phe Ala Ile 
        515                 520                 525             


Ile Ile Ala Tyr Phe 
    530             


<210>  2380
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  2380

Met Glu Thr Asn Phe Ser Thr Pro Leu Asn Glu Tyr Glu Glu Val Ser 
1               5                   10                  15      


Tyr Glu Ser Ala Gly Tyr Thr Val Leu Arg Ile Leu Pro Leu Val Val 
            20                  25                  30          


Leu Gly Val Thr Phe Val Leu Gly Val Leu Gly Asn Gly Leu Val Ile 
        35                  40                  45              


Trp Val Ala Gly Phe Arg Met Thr Arg Thr Val Thr Thr Ile Cys Tyr 
    50                  55                  60                  


Leu Asn Leu Ala Leu Ala Asp Phe Ser Phe Thr Ala Thr Leu Pro Phe 
65                  70                  75                  80  


Leu Ile Val Ser Met Ala Met Gly Glu Lys Trp Pro Phe Gly Trp Phe 
                85                  90                  95      


Leu Cys Lys Leu Ile His Ile Val Val Asp Ile Asn Leu Phe Gly Ser 
            100                 105                 110         


Val Phe Leu Ile Gly Phe Ile Ala Leu Asp Arg Cys Ile Cys Val Leu 
        115                 120                 125             


His Pro Val Trp Ala Gln Asn His Arg Thr Val Ser Leu Ala Met Lys 
    130                 135                 140                 


Val Ile Val Gly Pro Trp Ile Leu Ala Leu Val Leu Thr Leu Pro Val 
145                 150                 155                 160 


Phe Leu Phe Leu Thr Thr Val Thr Ile Pro Asn Gly Asp Thr Tyr Cys 
                165                 170                 175     


Thr Phe Asn Phe Ala Ser Trp Gly Gly Thr Pro Glu Glu Arg Leu Lys 
            180                 185                 190         


Val Ala Ile Thr Met Leu Thr Ala Arg Gly Ile Ile Arg Phe Val Ile 
        195                 200                 205             


Gly Phe Ser Leu Pro Met Ser Ile Val Ala Ile Cys Tyr Gly Leu Ile 
    210                 215                 220                 


Ala Ala Lys Ile His Lys Lys Gly Met Ile Lys Ser Ser Arg Pro Leu 
225                 230                 235                 240 


Arg Val Leu Thr Ala Val Val Ala Ser Phe Phe Ile Cys Trp Phe Pro 
                245                 250                 255     


Phe Gln Leu Val Ala Leu Leu Gly Thr Val Trp Leu Lys Glu Met Leu 
            260                 265                 270         


Phe Tyr Gly Lys Tyr Lys Ile Ile Asp Ile Leu Val Asn Pro Thr Ser 
        275                 280                 285             


Ser Leu Ala Phe Phe Asn Ser Cys Leu Asn Pro Met Leu Tyr Val Phe 
    290                 295                 300                 


Val Gly Gln Asp Phe Arg Glu Arg Leu Ile His Ser Leu Pro Thr Ser 
305                 310                 315                 320 


Leu Glu Arg Ala Leu Ser Glu Asp Ser Ala Pro Thr Asn Asp Thr Ala 
                325                 330                 335     


Ala Asn Ser Ala Ser Pro Pro Ala Glu Thr Glu Leu Gln Ala Met 
            340                 345                 350     


<210>  2381
<211>  735
<212>  PRT
<213>  Homo sapiens

<400>  2381

Met Trp Arg Val Leu Phe Leu Leu Ser Gly Leu Gly Gly Leu Arg Met 
1               5                   10                  15      


Asp Ser Asn Phe Asp Ser Leu Pro Val Gln Ile Thr Val Pro Glu Lys 
            20                  25                  30          


Ile Arg Ser Ile Ile Lys Glu Gly Ile Glu Ser Gln Ala Ser Tyr Lys 
        35                  40                  45              


Ile Val Ile Glu Gly Lys Pro Tyr Thr Val Asn Leu Met Gln Lys Asn 
    50                  55                  60                  


Phe Leu Pro His Asn Phe Arg Val Tyr Ser Tyr Ser Gly Thr Gly Ile 
65                  70                  75                  80  


Met Lys Pro Leu Asp Gln Asp Phe Gln Asn Phe Cys His Tyr Gln Gly 
                85                  90                  95      


Tyr Ile Glu Gly Tyr Pro Lys Ser Val Val Met Val Ser Thr Cys Thr 
            100                 105                 110         


Gly Leu Arg Gly Val Leu Gln Phe Glu Asn Val Ser Tyr Gly Ile Glu 
        115                 120                 125             


Pro Leu Glu Ser Ser Val Gly Phe Glu His Val Ile Tyr Gln Val Lys 
    130                 135                 140                 


His Lys Lys Ala Asp Val Ser Leu Tyr Asn Glu Lys Asp Ile Glu Ser 
145                 150                 155                 160 


Arg Asp Leu Ser Phe Lys Leu Gln Ser Val Glu Pro Gln Gln Asp Phe 
                165                 170                 175     


Ala Lys Tyr Ile Glu Met His Val Ile Val Glu Lys Gln Leu Tyr Asn 
            180                 185                 190         


His Met Gly Ser Asp Thr Thr Val Val Ala Gln Lys Val Phe Gln Leu 
        195                 200                 205             


Ile Gly Leu Thr Asn Ala Ile Phe Val Ser Phe Asn Ile Thr Ile Ile 
    210                 215                 220                 


Leu Ser Ser Leu Glu Leu Trp Ile Asp Glu Asn Lys Ile Ala Thr Thr 
225                 230                 235                 240 


Gly Glu Ala Asn Glu Leu Leu His Thr Phe Leu Arg Trp Lys Thr Ser 
                245                 250                 255     


Tyr Leu Val Leu Arg Pro His Asp Val Ala Phe Leu Leu Val Tyr Arg 
            260                 265                 270         


Glu Lys Ser Asn Tyr Val Gly Ala Thr Phe Gln Gly Lys Met Cys Asp 
        275                 280                 285             


Ala Asn Tyr Ala Gly Gly Val Val Leu His Pro Arg Thr Ile Ser Leu 
    290                 295                 300                 


Glu Ser Leu Ala Val Ile Leu Ala Gln Leu Leu Ser Leu Ser Met Gly 
305                 310                 315                 320 


Ile Thr Tyr Asp Asp Ile Asn Lys Cys Gln Cys Ser Gly Ala Val Cys 
                325                 330                 335     


Ile Met Asn Pro Glu Ala Ile His Phe Ser Gly Val Lys Ile Phe Ser 
            340                 345                 350         


Asn Cys Ser Phe Glu Asp Phe Ala His Phe Ile Ser Lys Gln Lys Ser 
        355                 360                 365             


Gln Cys Leu His Asn Gln Pro Arg Leu Asp Pro Phe Phe Lys Gln Gln 
    370                 375                 380                 


Ala Val Cys Gly Asn Ala Lys Leu Glu Ala Gly Glu Glu Cys Asp Cys 
385                 390                 395                 400 


Gly Thr Glu Gln Asp Cys Ala Leu Ile Gly Glu Thr Cys Cys Asp Ile 
                405                 410                 415     


Ala Thr Cys Arg Phe Lys Ala Gly Ser Asn Cys Ala Glu Gly Pro Cys 
            420                 425                 430         


Cys Glu Asn Cys Leu Phe Met Ser Lys Glu Arg Met Cys Arg Pro Ser 
        435                 440                 445             


Phe Glu Glu Cys Asp Leu Pro Glu Tyr Cys Asn Gly Ser Ser Ala Ser 
    450                 455                 460                 


Cys Pro Glu Asn His Tyr Val Gln Thr Gly His Pro Cys Gly Leu Asn 
465                 470                 475                 480 


Gln Trp Ile Cys Ile Asp Gly Val Cys Met Ser Gly Asp Lys Gln Cys 
                485                 490                 495     


Thr Asp Thr Phe Gly Lys Glu Val Glu Phe Gly Pro Ser Glu Cys Tyr 
            500                 505                 510         


Ser His Leu Asn Ser Lys Thr Asp Val Ser Gly Asn Cys Gly Ile Ser 
        515                 520                 525             


Asp Ser Gly Tyr Thr Gln Cys Glu Ala Asp Asn Leu Gln Cys Gly Lys 
    530                 535                 540                 


Leu Ile Cys Lys Tyr Val Gly Lys Phe Leu Leu Gln Ile Pro Arg Ala 
545                 550                 555                 560 


Thr Ile Ile Tyr Ala Asn Ile Ser Gly His Leu Cys Ile Ala Val Glu 
                565                 570                 575     


Phe Ala Ser Asp His Ala Asp Ser Gln Lys Met Trp Ile Lys Asp Gly 
            580                 585                 590         


Thr Ser Cys Gly Ser Asn Lys Val Cys Arg Asn Gln Arg Cys Val Ser 
        595                 600                 605             


Ser Ser Tyr Leu Gly Tyr Asp Cys Thr Thr Asp Lys Cys Asn Asp Arg 
    610                 615                 620                 


Gly Val Cys Asn Asn Lys Lys His Cys His Cys Ser Ala Ser Tyr Leu 
625                 630                 635                 640 


Pro Pro Asp Cys Ser Val Gln Ser Asp Leu Trp Pro Gly Gly Ser Ile 
                645                 650                 655     


Asp Ser Gly Asn Phe Pro Pro Val Ala Ile Pro Ala Arg Leu Pro Glu 
            660                 665                 670         


Arg Arg Tyr Ile Glu Asn Ile Tyr His Ser Lys Pro Met Arg Trp Pro 
        675                 680                 685             


Phe Phe Leu Phe Ile Pro Phe Phe Ile Ile Phe Cys Val Leu Ile Ala 
    690                 695                 700                 


Ile Met Val Lys Val Asn Phe Gln Arg Lys Lys Trp Arg Thr Glu Asp 
705                 710                 715                 720 


Tyr Ser Ser Asp Glu Gln Pro Glu Ser Glu Ser Glu Pro Lys Gly 
                725                 730                 735 


<210>  2382
<211>  565
<212>  PRT
<213>  Homo sapiens

<400>  2382

Met Arg Pro Arg Ser Ala Leu Pro Arg Leu Leu Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Pro Ala Ala Gly Pro Ala Gln Phe His Gly Glu Lys Gly Ile Ser 
            20                  25                  30          


Ile Pro Asp His Gly Phe Cys Gln Pro Ile Ser Ile Pro Leu Cys Thr 
        35                  40                  45              


Asp Ile Ala Tyr Asn Gln Thr Ile Met Pro Asn Leu Leu Gly His Thr 
    50                  55                  60                  


Asn Gln Glu Asp Ala Gly Leu Glu Val His Gln Phe Tyr Pro Leu Val 
65                  70                  75                  80  


Lys Val Gln Cys Ser Pro Glu Leu Arg Phe Phe Leu Cys Ser Met Tyr 
                85                  90                  95      


Ala Pro Val Cys Thr Val Leu Glu Gln Ala Ile Pro Pro Cys Arg Ser 
            100                 105                 110         


Ile Cys Glu Arg Ala Arg Gln Gly Cys Glu Ala Leu Met Asn Lys Phe 
        115                 120                 125             


Gly Phe Gln Trp Pro Glu Arg Leu Arg Cys Glu His Phe Pro Arg His 
    130                 135                 140                 


Gly Ala Glu Gln Ile Cys Val Gly Gln Asn His Ser Glu Asp Gly Ala 
145                 150                 155                 160 


Pro Ala Leu Leu Thr Thr Ala Pro Pro Pro Gly Leu Gln Pro Gly Ala 
                165                 170                 175     


Gly Gly Thr Pro Gly Gly Pro Gly Gly Gly Gly Ala Pro Pro Arg Tyr 
            180                 185                 190         


Ala Thr Leu Glu His Pro Phe His Cys Pro Arg Val Leu Lys Val Pro 
        195                 200                 205             


Ser Tyr Leu Ser Tyr Lys Phe Leu Gly Glu Arg Asp Cys Ala Ala Pro 
    210                 215                 220                 


Cys Glu Pro Ala Arg Pro Asp Gly Ser Met Phe Phe Ser Gln Glu Glu 
225                 230                 235                 240 


Thr Arg Phe Ala Arg Leu Trp Ile Leu Thr Trp Ser Val Leu Cys Cys 
                245                 250                 255     


Ala Ser Thr Phe Phe Thr Val Thr Thr Tyr Leu Val Asp Met Gln Arg 
            260                 265                 270         


Phe Arg Tyr Pro Glu Arg Pro Ile Ile Phe Leu Ser Gly Cys Tyr Thr 
        275                 280                 285             


Met Val Ser Val Ala Tyr Ile Ala Gly Phe Val Leu Gln Glu Arg Val 
    290                 295                 300                 


Val Cys Asn Glu Arg Phe Ser Glu Asp Gly Tyr Arg Thr Val Val Gln 
305                 310                 315                 320 


Gly Thr Lys Lys Glu Gly Cys Thr Ile Leu Phe Met Met Leu Tyr Phe 
                325                 330                 335     


Phe Ser Met Ala Ser Ser Ile Trp Trp Val Ile Leu Ser Leu Thr Trp 
            340                 345                 350         


Phe Leu Ala Ala Gly Met Lys Trp Gly His Glu Ala Ile Glu Ala Asn 
        355                 360                 365             


Ser Gln Tyr Phe His Leu Ala Ala Trp Ala Val Pro Ala Val Lys Thr 
    370                 375                 380                 


Ile Thr Ile Leu Ala Met Gly Gln Ile Asp Gly Asp Leu Leu Ser Gly 
385                 390                 395                 400 


Val Cys Phe Val Gly Leu Asn Ser Leu Asp Pro Leu Arg Gly Phe Val 
                405                 410                 415     


Leu Ala Pro Leu Phe Val Tyr Leu Phe Ile Gly Thr Ser Phe Leu Leu 
            420                 425                 430         


Ala Gly Phe Val Ser Leu Phe Arg Ile Arg Thr Ile Met Lys His Asp 
        435                 440                 445             


Gly Thr Lys Thr Glu Lys Leu Glu Arg Leu Met Val Arg Ile Gly Val 
    450                 455                 460                 


Phe Ser Val Leu Tyr Thr Val Pro Ala Thr Ile Val Ile Ala Cys Tyr 
465                 470                 475                 480 


Phe Tyr Glu Gln Ala Phe Arg Glu His Trp Glu Arg Ser Trp Val Ser 
                485                 490                 495     


Gln His Cys Lys Ser Leu Ala Ile Pro Cys Pro Ala His Tyr Thr Pro 
            500                 505                 510         


Arg Met Ser Pro Asp Phe Thr Val Tyr Met Ile Lys Tyr Leu Met Thr 
        515                 520                 525             


Leu Ile Val Gly Ile Thr Ser Gly Phe Trp Ile Trp Ser Gly Lys Thr 
    530                 535                 540                 


Leu His Ser Trp Arg Lys Phe Tyr Thr Arg Leu Thr Asn Ser Arg His 
545                 550                 555                 560 


Gly Glu Thr Thr Val 
                565 


<210>  2383
<211>  429
<212>  PRT
<213>  Homo sapiens

<400>  2383

Met Ala Ala Gln Gly Tyr Gly Tyr Tyr Arg Thr Val Ile Phe Ser Ala 
1               5                   10                  15      


Met Phe Gly Gly Tyr Ser Leu Tyr Tyr Phe Asn Arg Lys Thr Phe Ser 
            20                  25                  30          


Phe Val Met Pro Ser Leu Val Glu Glu Ile Pro Leu Asp Lys Asp Asp 
        35                  40                  45              


Leu Gly Phe Ile Thr Ser Ser Gln Ser Ala Ala Tyr Ala Ile Ser Lys 
    50                  55                  60                  


Phe Val Ser Gly Val Leu Ser Asp Gln Met Ser Ala Arg Trp Leu Phe 
65                  70                  75                  80  


Ser Ser Gly Leu Leu Leu Val Gly Leu Val Asn Ile Phe Phe Ala Trp 
                85                  90                  95      


Ser Ser Thr Val Pro Val Phe Ala Ala Leu Trp Phe Leu Asn Gly Leu 
            100                 105                 110         


Ala Gln Gly Leu Gly Trp Pro Pro Cys Gly Lys Val Leu Arg Lys Trp 
        115                 120                 125             


Phe Glu Pro Ser Gln Phe Gly Thr Trp Trp Ala Ile Leu Ser Thr Ser 
    130                 135                 140                 


Met Asn Leu Ala Gly Gly Leu Gly Pro Ile Leu Ala Thr Ile Leu Ala 
145                 150                 155                 160 


Gln Ser Tyr Ser Trp Arg Ser Thr Leu Ala Leu Ser Gly Ala Leu Cys 
                165                 170                 175     


Val Val Val Ser Phe Leu Cys Leu Leu Leu Ile His Asn Glu Pro Ala 
            180                 185                 190         


Asp Val Gly Leu Arg Asn Leu Asp Pro Met Pro Ser Glu Gly Lys Lys 
        195                 200                 205             


Gly Ser Leu Lys Glu Glu Ser Thr Leu Gln Glu Leu Leu Leu Ser Pro 
    210                 215                 220                 


Tyr Leu Trp Val Leu Ser Thr Gly Tyr Leu Val Val Phe Gly Val Lys 
225                 230                 235                 240 


Thr Cys Cys Thr Asp Trp Gly Gln Phe Phe Leu Ile Gln Glu Lys Gly 
                245                 250                 255     


Gln Ser Ala Leu Val Gly Ser Ser Tyr Met Ser Ala Leu Glu Val Gly 
            260                 265                 270         


Gly Leu Val Gly Ser Ile Ala Ala Gly Tyr Leu Ser Asp Arg Ala Met 
        275                 280                 285             


Ala Lys Ala Gly Leu Ser Asn Tyr Gly Asn Pro Arg His Gly Leu Leu 
    290                 295                 300                 


Leu Phe Met Met Ala Gly Met Thr Val Ser Met Tyr Leu Phe Arg Val 
305                 310                 315                 320 


Thr Val Thr Ser Asp Ser Pro Lys Leu Trp Ile Leu Val Leu Gly Ala 
                325                 330                 335     


Val Phe Gly Phe Ser Ser Tyr Gly Pro Ile Ala Leu Phe Gly Val Ile 
            340                 345                 350         


Ala Asn Glu Ser Ala Pro Pro Asn Leu Cys Gly Thr Ser His Ala Ile 
        355                 360                 365             


Val Gly Leu Met Ala Asn Val Gly Gly Phe Leu Ala Gly Leu Pro Phe 
    370                 375                 380                 


Ser Thr Ile Ala Lys His Tyr Ser Trp Ser Thr Ala Phe Trp Val Ala 
385                 390                 395                 400 


Glu Val Ile Cys Ala Ala Ser Thr Ala Ala Phe Phe Leu Leu Arg Asn 
                405                 410                 415     


Ile Arg Thr Lys Met Gly Arg Val Ser Lys Lys Ala Glu 
            420                 425                 


<210>  2384
<211>  961
<212>  PRT
<213>  Homo sapiens

<400>  2384

Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe Leu Arg Pro Pro Gly 
1               5                   10                  15      


Ala Gly Gly Ala Gln Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile 
            20                  25                  30          


Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg 
        35                  40                  45              


Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu 
    50                  55                  60                  


Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys 
65                  70                  75                  80  


Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys 
                85                  90                  95      


Val Arg Ile Cys Ser Lys Ser Tyr Leu Thr Leu Glu Asn Gly Lys Val 
            100                 105                 110         


Phe Leu Thr Gly Gly Asp Leu Pro Ala Leu Asp Gly Ala Arg Val Asp 
        115                 120                 125             


Phe Arg Cys Asp Pro Asp Phe His Leu Val Gly Ser Ser Arg Ser Ile 
    130                 135                 140                 


Cys Ser Gln Gly Gln Trp Ser Thr Pro Lys Pro His Cys Gln Val Asn 
145                 150                 155                 160 


Arg Thr Pro His Ser Glu Arg Arg Ala Val Tyr Ile Gly Ala Leu Phe 
                165                 170                 175     


Pro Met Ser Gly Gly Trp Pro Gly Gly Gln Ala Cys Gln Pro Ala Val 
            180                 185                 190         


Glu Met Ala Leu Glu Asp Val Asn Ser Arg Arg Asp Ile Leu Pro Asp 
        195                 200                 205             


Tyr Glu Leu Lys Leu Ile His His Asp Ser Lys Cys Asp Pro Gly Gln 
    210                 215                 220                 


Ala Thr Lys Tyr Leu Tyr Glu Leu Leu Tyr Asn Asp Pro Ile Lys Ile 
225                 230                 235                 240 


Ile Leu Met Pro Gly Cys Ser Ser Val Ser Thr Leu Val Ala Glu Ala 
                245                 250                 255     


Ala Arg Met Trp Asn Leu Ile Val Leu Ser Tyr Gly Ser Ser Ser Pro 
            260                 265                 270         


Ala Leu Ser Asn Arg Gln Arg Phe Pro Thr Phe Phe Arg Thr His Pro 
        275                 280                 285             


Ser Ala Thr Leu His Asn Pro Thr Arg Val Lys Leu Phe Glu Lys Trp 
    290                 295                 300                 


Gly Trp Lys Lys Ile Ala Thr Ile Gln Gln Thr Thr Glu Val Phe Thr 
305                 310                 315                 320 


Ser Thr Leu Asp Asp Leu Glu Glu Arg Val Lys Glu Ala Gly Ile Glu 
                325                 330                 335     


Ile Thr Phe Arg Gln Ser Phe Phe Ser Asp Pro Ala Val Pro Val Lys 
            340                 345                 350         


Asn Leu Lys Arg Gln Asp Ala Arg Ile Ile Val Gly Leu Phe Tyr Glu 
        355                 360                 365             


Thr Glu Ala Arg Lys Val Phe Cys Glu Val Tyr Lys Glu Arg Leu Phe 
    370                 375                 380                 


Gly Lys Lys Tyr Val Trp Phe Leu Ile Gly Trp Tyr Ala Asp Asn Trp 
385                 390                 395                 400 


Phe Lys Ile Tyr Asp Pro Ser Ile Asn Cys Thr Val Asp Glu Met Thr 
                405                 410                 415     


Glu Ala Val Glu Gly His Ile Thr Thr Glu Ile Val Met Leu Asn Pro 
            420                 425                 430         


Ala Asn Thr Arg Ser Ile Ser Asn Met Thr Ser Gln Glu Phe Val Glu 
        435                 440                 445             


Lys Leu Thr Lys Arg Leu Lys Arg His Pro Glu Glu Thr Gly Gly Phe 
    450                 455                 460                 


Gln Glu Ala Pro Leu Ala Tyr Asp Ala Ile Trp Ala Leu Ala Leu Ala 
465                 470                 475                 480 


Leu Asn Lys Thr Ser Gly Gly Gly Gly Arg Ser Gly Val Arg Leu Glu 
                485                 490                 495     


Asp Phe Asn Tyr Asn Asn Gln Thr Ile Thr Asp Gln Ile Tyr Arg Ala 
            500                 505                 510         


Met Asn Ser Ser Ser Phe Glu Gly Val Ser Gly His Val Val Phe Asp 
        515                 520                 525             


Ala Ser Gly Ser Arg Met Ala Trp Thr Leu Ile Glu Gln Leu Gln Gly 
    530                 535                 540                 


Gly Ser Tyr Lys Lys Ile Gly Tyr Tyr Asp Ser Thr Lys Asp Asp Leu 
545                 550                 555                 560 


Ser Trp Ser Lys Thr Asp Lys Trp Ile Gly Gly Ser Pro Pro Ala Asp 
                565                 570                 575     


Gln Thr Leu Val Ile Lys Thr Phe Arg Phe Leu Ser Gln Lys Leu Phe 
            580                 585                 590         


Ile Ser Val Ser Val Leu Ser Ser Leu Gly Ile Val Leu Ala Val Val 
        595                 600                 605             


Cys Leu Ser Phe Asn Ile Tyr Asn Ser His Val Arg Tyr Ile Gln Asn 
    610                 615                 620                 


Ser Gln Pro Asn Leu Asn Asn Leu Thr Ala Val Gly Cys Ser Leu Ala 
625                 630                 635                 640 


Leu Ala Ala Val Phe Pro Leu Gly Leu Asp Gly Tyr His Ile Gly Arg 
                645                 650                 655     


Asn Gln Phe Pro Phe Val Cys Gln Ala Arg Leu Trp Leu Leu Gly Leu 
            660                 665                 670         


Gly Phe Ser Leu Gly Tyr Gly Ser Met Phe Thr Lys Ile Trp Trp Val 
        675                 680                 685             


His Thr Val Phe Thr Lys Lys Glu Glu Lys Lys Glu Trp Arg Lys Thr 
    690                 695                 700                 


Leu Glu Pro Trp Lys Leu Tyr Ala Thr Val Gly Leu Leu Val Gly Met 
705                 710                 715                 720 


Asp Val Leu Thr Leu Ala Ile Trp Gln Ile Val Asp Pro Leu His Arg 
                725                 730                 735     


Thr Ile Glu Thr Phe Ala Lys Glu Glu Pro Lys Glu Asp Ile Asp Val 
            740                 745                 750         


Ser Ile Leu Pro Gln Leu Glu His Cys Ser Ser Arg Lys Met Asn Thr 
        755                 760                 765             


Trp Leu Gly Ile Phe Tyr Gly Tyr Lys Gly Leu Leu Leu Leu Leu Gly 
    770                 775                 780                 


Ile Phe Leu Ala Tyr Glu Thr Lys Ser Val Ser Thr Glu Lys Ile Asn 
785                 790                 795                 800 


Asp His Arg Ala Val Gly Met Ala Ile Tyr Asn Val Ala Val Leu Cys 
                805                 810                 815     


Leu Ile Thr Ala Pro Val Thr Met Ile Leu Ser Ser Gln Gln Asp Ala 
            820                 825                 830         


Ala Phe Ala Phe Ala Ser Leu Ala Ile Val Phe Ser Ser Tyr Ile Thr 
        835                 840                 845             


Leu Val Val Leu Phe Val Pro Lys Met Arg Arg Leu Ile Thr Arg Gly 
    850                 855                 860                 


Glu Trp Gln Ser Glu Ala Gln Asp Thr Met Lys Thr Gly Ser Ser Thr 
865                 870                 875                 880 


Asn Asn Asn Glu Glu Glu Lys Ser Arg Leu Leu Glu Lys Glu Asn Arg 
                885                 890                 895     


Glu Leu Glu Lys Ile Ile Ala Glu Lys Glu Glu Arg Val Ser Glu Leu 
            900                 905                 910         


Arg His Gln Leu Gln Ser Arg Gln Gln Leu Arg Ser Arg Arg His Pro 
        915                 920                 925             


Pro Thr Pro Pro Glu Pro Ser Gly Gly Leu Pro Arg Gly Pro Pro Glu 
    930                 935                 940                 


Pro Pro Asp Arg Leu Ser Cys Asp Gly Ser Arg Val His Leu Leu Tyr 
945                 950                 955                 960 


Lys 
    


<210>  2385
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  2385

Met Trp Leu Gly Arg Arg Ala Leu Cys Ala Leu Val Leu Leu Leu Ala 
1               5                   10                  15      


Cys Ala Ser Leu Gly Leu Leu Tyr Ala Ser Thr Arg Asp Ala Pro Gly 
            20                  25                  30          


Leu Arg Leu Pro Leu Ala Pro Trp Ala Pro Pro Gln Ser Pro Arg Arg 
        35                  40                  45              


Pro Glu Leu Pro Asp Leu Ala Pro Glu Pro Arg Tyr Ala His Ile Pro 
    50                  55                  60                  


Val Arg Ile Lys Glu Gln Val Val Gly Leu Leu Ala Trp Asn Asn Cys 
65                  70                  75                  80  


Ser Cys Glu Ser Ser Gly Gly Gly Leu Pro Leu Pro Phe Gln Lys Gln 
                85                  90                  95      


Val Arg Ala Ile Asp Leu Thr Lys Ala Phe Asp Pro Ala Glu Leu Arg 
            100                 105                 110         


Ala Ala Ser Ala Thr Arg Glu Gln Glu Phe Gln Ala Phe Leu Ser Arg 
        115                 120                 125             


Ser Gln Ser Pro Ala Asp Gln Leu Leu Ile Ala Pro Ala Asn Ser Pro 
    130                 135                 140                 


Leu Gln Tyr Pro Leu Gln Gly Val Glu Val Gln Pro Leu Arg Ser Ile 
145                 150                 155                 160 


Leu Val Pro Gly Leu Ser Leu Gln Ala Ala Ser Gly Gln Glu Val Tyr 
                165                 170                 175     


Gln Val Asn Leu Thr Ala Ser Leu Gly Thr Trp Asp Val Ala Gly Glu 
            180                 185                 190         


Val Thr Gly Val Thr Leu Thr Gly Glu Gly Gln Ala Asp Leu Thr Leu 
        195                 200                 205             


Val Ser Pro Gly Leu Asp Gln Leu Asn Arg Gln Leu Gln Leu Val Thr 
    210                 215                 220                 


Tyr Ser Ser Arg Ser Tyr Gln Thr Asn Thr Ala Asp Thr Val Arg Phe 
225                 230                 235                 240 


Ser Thr Glu Gly His Glu Ala Ala Phe Thr Ile Arg Ile Arg His Pro 
                245                 250                 255     


Pro Asn Pro Arg Leu Tyr Pro Pro Gly Ser Leu Pro Gln Gly Ala Gln 
            260                 265                 270         


Tyr Asn Ile Ser Ala Leu Val Thr Ile Ala Thr Lys Thr Phe Leu Arg 
        275                 280                 285             


Tyr Asp Arg Leu Arg Ala Leu Ile Thr Ser Ile Arg Arg Phe Tyr Pro 
    290                 295                 300                 


Thr Val Thr Val Val Ile Ala Asp Asp Ser Asp Lys Pro Glu Arg Val 
305                 310                 315                 320 


Ser Gly Pro Tyr Val Glu His Tyr Leu Met Pro Phe Gly Lys Gly Trp 
                325                 330                 335     


Phe Ala Gly Arg Asn Leu Ala Val Ser Gln Val Thr Thr Lys Tyr Val 
            340                 345                 350         


Leu Trp Val Asp Asp Asp Phe Val Phe Thr Ala Arg Thr Arg Leu Glu 
        355                 360                 365             


Arg Leu Val Asp Val Leu Glu Arg Thr Pro Leu Asp Leu Val Gly Gly 
    370                 375                 380                 


Ala Val Arg Glu Ile Ser Gly Phe Ala Thr Thr Tyr Arg Gln Leu Leu 
385                 390                 395                 400 


Ser Val Glu Pro Gly Ala Pro Gly Leu Gly Asn Cys Leu Arg Gln Arg 
                405                 410                 415     


Arg Gly Phe His His Glu Leu Val Gly Phe Pro Gly Cys Val Val Thr 
            420                 425                 430         


Asp Gly Val Val Asn Phe Phe Leu Ala Arg Thr Asp Lys Val Arg Glu 
        435                 440                 445             


Val Gly Phe Asp Pro Arg Leu Ser Arg Val Ala His Leu Glu Phe Phe 
    450                 455                 460                 


Leu Asp Gly Leu Gly Ser Leu Arg Val Gly Ser Cys Ser Asp Val Val 
465                 470                 475                 480 


Val Asp His Ala Ser Lys Leu Lys Leu Pro Trp Thr Ser Arg Asp Ala 
                485                 490                 495     


Gly Ala Glu Thr Tyr Ala Arg Tyr Arg Tyr Pro Gly Ser Leu Asp Glu 
            500                 505                 510         


Ser Gln Met Ala Lys His Arg Leu Leu Phe Phe Lys His Arg Leu Gln 
        515                 520                 525             


Cys Met Thr Ser Gln 
    530             


<210>  2386
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  2386

Met Glu Leu Ala Val Gly Asn Leu Ser Glu Gly Asn Ala Ser Trp Pro 
1               5                   10                  15      


Glu Pro Pro Ala Pro Glu Pro Gly Pro Leu Phe Gly Ile Gly Val Glu 
            20                  25                  30          


Asn Phe Val Thr Leu Val Val Phe Gly Leu Ile Phe Ala Leu Gly Val 
        35                  40                  45              


Leu Gly Asn Ser Leu Val Ile Thr Val Leu Ala Arg Ser Lys Pro Gly 
    50                  55                  60                  


Lys Pro Arg Ser Thr Thr Asn Leu Phe Ile Leu Asn Leu Ser Ile Ala 
65                  70                  75                  80  


Asp Leu Ala Tyr Leu Leu Phe Cys Ile Pro Phe Gln Ala Thr Val Tyr 
                85                  90                  95      


Ala Leu Pro Thr Trp Val Leu Gly Ala Phe Ile Cys Lys Phe Ile His 
            100                 105                 110         


Tyr Phe Phe Thr Val Ser Met Leu Val Ser Ile Phe Thr Leu Ala Ala 
        115                 120                 125             


Met Ser Val Asp Arg Tyr Val Ala Ile Val His Ser Arg Arg Ser Ser 
    130                 135                 140                 


Ser Leu Arg Val Ser Arg Asn Ala Leu Leu Gly Val Gly Cys Ile Trp 
145                 150                 155                 160 


Ala Leu Ser Ile Ala Met Ala Ser Pro Val Ala Tyr His Gln Gly Leu 
                165                 170                 175     


Phe His Pro Arg Ala Ser Asn Gln Thr Phe Cys Trp Glu Gln Trp Pro 
            180                 185                 190         


Asp Pro Arg His Lys Lys Ala Tyr Val Val Cys Thr Phe Val Phe Gly 
        195                 200                 205             


Tyr Leu Leu Pro Leu Leu Leu Ile Cys Phe Cys Tyr Ala Lys Val Leu 
    210                 215                 220                 


Asn His Leu His Lys Lys Leu Lys Asn Met Ser Lys Lys Ser Glu Ala 
225                 230                 235                 240 


Ser Lys Lys Lys Thr Ala Gln Thr Val Leu Val Val Val Val Val Phe 
                245                 250                 255     


Gly Ile Ser Trp Leu Pro His His Ile Ile His Leu Trp Ala Glu Phe 
            260                 265                 270         


Gly Val Phe Pro Leu Thr Pro Ala Ser Phe Leu Phe Arg Ile Thr Ala 
        275                 280                 285             


His Cys Leu Ala Tyr Ser Asn Ser Ser Val Asn Pro Ile Ile Tyr Ala 
    290                 295                 300                 


Phe Leu Ser Glu Asn Phe Arg Lys Ala Tyr Lys Gln Val Phe Lys Cys 
305                 310                 315                 320 


His Ile Arg Lys Asp Ser His Leu Ser Asp Thr Lys Glu Ser Lys Ser 
                325                 330                 335     


Arg Ile Asp Thr Pro Pro Ser Thr Asn Cys Thr His Val 
            340                 345                 


<210>  2387
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  2387

Met Leu Arg Thr Leu Leu Arg Arg Arg Leu Phe Ser Tyr Pro Thr Lys 
1               5                   10                  15      


Tyr Tyr Phe Met Val Leu Val Leu Ser Leu Ile Thr Phe Ser Val Leu 
            20                  25                  30          


Arg Ile His Gln Lys Pro Glu Phe Val Ser Val Arg His Leu Glu Leu 
        35                  40                  45              


Ala Gly Glu Asn Pro Ser Ser Asp Ile Asn Cys Thr Lys Val Leu Gln 
    50                  55                  60                  


Gly Asp Val Asn Glu Ile Gln Lys Val Lys Leu Glu Ile Leu Thr Val 
65                  70                  75                  80  


Lys Phe Lys Lys Arg Pro Arg Trp Thr Pro Asp Asp Tyr Ile Asn Met 
                85                  90                  95      


Thr Ser Asp Cys Ser Ser Phe Ile Lys Arg Arg Lys Tyr Ile Val Glu 
            100                 105                 110         


Pro Leu Ser Lys Glu Glu Ala Glu Phe Pro Ile Ala Tyr Ser Ile Val 
        115                 120                 125             


Val His His Lys Ile Glu Met Leu Asp Arg Leu Leu Arg Ala Ile Tyr 
    130                 135                 140                 


Met Pro Gln Asn Phe Tyr Cys Ile His Val Asp Thr Lys Ser Glu Asp 
145                 150                 155                 160 


Ser Tyr Leu Ala Ala Val Met Gly Ile Ala Ser Cys Phe Ser Asn Val 
                165                 170                 175     


Phe Val Ala Ser Arg Leu Glu Ser Val Val Tyr Ala Ser Trp Ser Arg 
            180                 185                 190         


Val Gln Ala Asp Leu Asn Cys Met Lys Asp Leu Tyr Ala Met Ser Ala 
        195                 200                 205             


Asn Trp Lys Tyr Leu Ile Asn Leu Cys Gly Met Asp Phe Pro Ile Lys 
    210                 215                 220                 


Thr Asn Leu Glu Ile Val Arg Lys Leu Lys Leu Leu Met Gly Glu Asn 
225                 230                 235                 240 


Asn Leu Glu Thr Glu Arg Met Pro Ser His Lys Glu Glu Arg Trp Lys 
                245                 250                 255     


Lys Arg Tyr Glu Val Val Asn Gly Lys Leu Thr Asn Thr Gly Thr Val 
            260                 265                 270         


Lys Met Leu Pro Pro Leu Glu Thr Pro Leu Phe Ser Gly Ser Ala Tyr 
        275                 280                 285             


Phe Val Val Ser Arg Glu Tyr Val Gly Tyr Val Leu Gln Asn Glu Lys 
    290                 295                 300                 


Ile Gln Lys Leu Met Glu Trp Ala Gln Asp Thr Tyr Ser Pro Asp Glu 
305                 310                 315                 320 


Tyr Leu Trp Ala Thr Ile Gln Arg Ile Pro Glu Val Pro Gly Ser Leu 
                325                 330                 335     


Pro Ala Ser His Lys Tyr Asp Leu Ser Asp Met Gln Ala Val Ala Arg 
            340                 345                 350         


Phe Val Lys Trp Gln Tyr Phe Glu Gly Asp Val Ser Lys Gly Ala Pro 
        355                 360                 365             


Tyr Pro Pro Cys Asp Gly Val His Val Arg Ser Val Cys Ile Phe Gly 
    370                 375                 380                 


Ala Gly Asp Leu Asn Trp Met Leu Arg Lys His His Leu Phe Ala Asn 
385                 390                 395                 400 


Lys Phe Asp Val Asp Val Asp Leu Phe Ala Ile Gln Cys Leu Asp Glu 
                405                 410                 415     


His Leu Arg His Lys Ala Leu Glu Thr Leu Lys His 
            420                 425             


<210>  2388
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  2388

Met Pro Leu Ser Met Arg Tyr Leu Phe Ile Ile Ser Val Ser Ser Val 
1               5                   10                  15      


Ile Ile Phe Ile Val Phe Ser Val Phe Asn Phe Gly Gly Asp Pro Ser 
            20                  25                  30          


Phe Gln Arg Leu Asn Ile Ser Asp Pro Leu Arg Leu Thr Gln Val Cys 
        35                  40                  45              


Thr Ser Phe Ile Asn Gly Lys Thr Arg Phe Leu Trp Lys Asn Lys Leu 
    50                  55                  60                  


Met Ile His Glu Lys Ser Ser Cys Lys Glu Tyr Leu Thr Gln Ser His 
65                  70                  75                  80  


Tyr Ile Thr Ala Pro Leu Ser Lys Glu Glu Ala Asp Phe Pro Leu Ala 
                85                  90                  95      


Tyr Ile Met Val Ile His His His Phe Asp Thr Phe Ala Arg Leu Phe 
            100                 105                 110         


Arg Ala Ile Tyr Met Pro Gln Asn Ile Tyr Cys Val His Val Asp Glu 
        115                 120                 125             


Lys Ala Thr Thr Glu Phe Lys Asp Ala Val Glu Gln Leu Leu Ser Cys 
    130                 135                 140                 


Phe Pro Asn Ala Phe Leu Ala Ser Lys Met Glu Pro Val Val Tyr Gly 
145                 150                 155                 160 


Gly Ile Ser Arg Leu Gln Ala Asp Leu Asn Cys Ile Arg Asp Leu Ser 
                165                 170                 175     


Ala Phe Glu Val Ser Trp Lys Tyr Val Ile Asn Thr Cys Gly Gln Asp 
            180                 185                 190         


Phe Pro Leu Lys Thr Asn Lys Glu Ile Val Gln Tyr Leu Lys Gly Phe 
        195                 200                 205             


Lys Gly Lys Asn Ile Thr Pro Gly Val Leu Pro Pro Ala His Ala Ile 
    210                 215                 220                 


Gly Arg Thr Lys Tyr Val His Gln Glu His Leu Gly Lys Glu Leu Ser 
225                 230                 235                 240 


Tyr Val Ile Arg Thr Thr Ala Leu Lys Pro Pro Pro Pro His Asn Leu 
                245                 250                 255     


Thr Ile Tyr Phe Gly Ser Ala Tyr Val Ala Leu Ser Arg Glu Phe Ala 
            260                 265                 270         


Asn Phe Val Leu His Asp Pro Arg Ala Val Asp Leu Leu Gln Trp Ser 
        275                 280                 285             


Lys Asp Thr Phe Ser Pro Asp Glu His Phe Trp Val Thr Leu Asn Arg 
    290                 295                 300                 


Ile Pro Gly Val Pro Gly Ser Met Pro Asn Ala Ser Trp Thr Gly Asn 
305                 310                 315                 320 


Leu Arg Ala Ile Lys Trp Ser Asp Met Glu Asp Arg His Gly Gly Cys 
                325                 330                 335     


His Gly His Tyr Val His Gly Ile Cys Ile Tyr Gly Asn Gly Asp Leu 
            340                 345                 350         


Lys Trp Leu Val Asn Ser Pro Ser Leu Phe Ala Asn Lys Phe Glu Leu 
        355                 360                 365             


Asn Thr Tyr Pro Leu Thr Val Glu Cys Leu Glu Leu Arg His Arg Glu 
    370                 375                 380                 


Arg Thr Leu Asn Gln Ser Glu Thr Ala Ile Gln Pro Ser Trp Tyr Phe 
385                 390                 395                 400 


<210>  2389
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  2389

Met Pro Pro Pro Gln Gln Gly Pro Cys Gly His His Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Leu Leu Leu Pro Ser Leu Pro Leu Thr Arg Ala Pro Val Pro 
            20                  25                  30          


Pro Gly Pro Ala Ala Ala Leu Leu Gln Ala Leu Gly Leu Arg Asp Glu 
        35                  40                  45              


Pro Gln Gly Ala Pro Arg Leu Arg Pro Val Pro Pro Val Met Trp Arg 
    50                  55                  60                  


Leu Phe Arg Arg Arg Asp Pro Gln Glu Thr Arg Ser Gly Ser Arg Arg 
65                  70                  75                  80  


Thr Ser Pro Gly Val Thr Leu Gln Pro Cys His Val Glu Glu Leu Gly 
                85                  90                  95      


Val Ala Gly Asn Ile Val Arg His Ile Pro Asp Arg Gly Ala Pro Thr 
            100                 105                 110         


Arg Ala Ser Glu Pro Ala Ser Ala Ala Gly His Cys Pro Glu Trp Thr 
        115                 120                 125             


Val Val Phe Asp Leu Ser Ala Val Glu Pro Ala Glu Arg Pro Ser Arg 
    130                 135                 140                 


Ala Arg Leu Glu Leu Arg Phe Ala Ala Ala Ala Ala Ala Ala Pro Glu 
145                 150                 155                 160 


Gly Gly Trp Glu Leu Ser Val Ala Gln Ala Gly Gln Gly Ala Gly Ala 
                165                 170                 175     


Asp Pro Gly Pro Val Leu Leu Arg Gln Leu Val Pro Ala Leu Gly Pro 
            180                 185                 190         


Pro Val Arg Ala Glu Leu Leu Gly Ala Ala Trp Ala Arg Asn Ala Ser 
        195                 200                 205             


Trp Pro Arg Ser Leu Arg Leu Ala Leu Ala Leu Arg Pro Arg Ala Pro 
    210                 215                 220                 


Ala Ala Cys Ala Arg Leu Ala Glu Ala Ser Leu Leu Leu Val Thr Leu 
225                 230                 235                 240 


Asp Pro Arg Leu Cys His Pro Leu Ala Arg Pro Arg Arg Asp Ala Glu 
                245                 250                 255     


Pro Val Leu Gly Gly Gly Pro Gly Gly Ala Cys Arg Ala Arg Arg Leu 
            260                 265                 270         


Tyr Val Ser Phe Arg Glu Val Gly Trp His Arg Trp Val Ile Ala Pro 
        275                 280                 285             


Arg Gly Phe Leu Ala Asn Tyr Cys Gln Gly Gln Cys Ala Leu Pro Val 
    290                 295                 300                 


Ala Leu Ser Gly Ser Gly Gly Pro Pro Ala Leu Asn His Ala Val Leu 
305                 310                 315                 320 


Arg Ala Leu Met His Ala Ala Ala Pro Gly Ala Ala Asp Leu Pro Cys 
                325                 330                 335     


Cys Val Pro Ala Arg Leu Ser Pro Ile Ser Val Leu Phe Phe Asp Asn 
            340                 345                 350         


Ser Asp Asn Val Val Leu Arg Gln Tyr Glu Asp Met Val Val Asp Glu 
        355                 360                 365             


Cys Gly Cys Arg 
    370         


<210>  2390
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  2390

Met Arg Leu Arg Glu Pro Leu Leu Ser Gly Ser Ala Ala Met Pro Gly 
1               5                   10                  15      


Ala Ser Leu Gln Arg Ala Cys Arg Leu Leu Val Ala Val Cys Ala Leu 
            20                  25                  30          


His Leu Gly Val Thr Leu Val Tyr Tyr Leu Ala Gly Arg Asp Leu Ser 
        35                  40                  45              


Arg Leu Pro Gln Leu Val Gly Val Ser Thr Pro Leu Gln Gly Gly Ser 
    50                  55                  60                  


Asn Ser Ala Ala Ala Ile Gly Gln Ser Ser Gly Glu Leu Arg Thr Gly 
65                  70                  75                  80  


Gly Ala Arg Pro Pro Pro Pro Leu Gly Ala Ser Ser Gln Pro Arg Pro 
                85                  90                  95      


Gly Gly Asp Ser Ser Pro Val Val Asp Ser Gly Pro Gly Pro Ala Ser 
            100                 105                 110         


Asn Leu Thr Ser Val Pro Val Pro His Thr Thr Ala Leu Ser Leu Pro 
        115                 120                 125             


Ala Cys Pro Glu Glu Ser Pro Leu Leu Val Gly Pro Met Leu Ile Glu 
    130                 135                 140                 


Phe Asn Met Pro Val Asp Leu Glu Leu Val Ala Lys Gln Asn Pro Asn 
145                 150                 155                 160 


Val Lys Met Gly Gly Arg Tyr Ala Pro Arg Asp Cys Val Ser Pro His 
                165                 170                 175     


Lys Val Ala Ile Ile Ile Pro Phe Arg Asn Arg Gln Glu His Leu Lys 
            180                 185                 190         


Tyr Trp Leu Tyr Tyr Leu His Pro Val Leu Gln Arg Gln Gln Leu Asp 
        195                 200                 205             


Tyr Gly Ile Tyr Val Ile Asn Gln Ala Gly Asp Thr Ile Phe Asn Arg 
    210                 215                 220                 


Ala Lys Leu Leu Asn Val Gly Phe Gln Glu Ala Leu Lys Asp Tyr Asp 
225                 230                 235                 240 


Tyr Thr Cys Phe Val Phe Ser Asp Val Asp Leu Ile Pro Met Asn Asp 
                245                 250                 255     


His Asn Ala Tyr Arg Cys Phe Ser Gln Pro Arg His Ile Ser Val Ala 
            260                 265                 270         


Met Asp Lys Phe Gly Phe Ser Leu Pro Tyr Val Gln Tyr Phe Gly Gly 
        275                 280                 285             


Val Ser Ala Leu Ser Lys Gln Gln Phe Leu Thr Ile Asn Gly Phe Pro 
    290                 295                 300                 


Asn Asn Tyr Trp Gly Trp Gly Gly Glu Asp Asp Asp Ile Phe Asn Arg 
305                 310                 315                 320 


Leu Val Phe Arg Gly Met Ser Ile Ser Arg Pro Asn Ala Val Val Gly 
                325                 330                 335     


Arg Cys Arg Met Ile Arg His Ser Arg Asp Lys Lys Asn Glu Pro Asn 
            340                 345                 350         


Pro Gln Arg Phe Asp Arg Ile Ala His Thr Lys Glu Thr Met Leu Ser 
        355                 360                 365             


Asp Gly Leu Asn Ser Leu Thr Tyr Gln Val Leu Asp Val Gln Arg Tyr 
    370                 375                 380                 


Pro Leu Tyr Thr Gln Ile Thr Val Asp Ile Gly Thr Pro Ser 
385                 390                 395             


<210>  2391
<211>  637
<212>  PRT
<213>  Homo sapiens

<400>  2391

Met Gly Leu Leu Ser Gln Gly Ser Pro Leu Ser Trp Glu Glu Thr Lys 
1               5                   10                  15      


Arg His Ala Asp His Val Arg Arg His Gly Ile Leu Gln Phe Leu His 
            20                  25                  30          


Ile Tyr His Ala Val Lys Asp Arg His Lys Asp Val Leu Lys Trp Gly 
        35                  40                  45              


Asp Glu Val Glu Tyr Met Leu Val Ser Phe Asp His Glu Asn Lys Lys 
    50                  55                  60                  


Val Arg Leu Val Leu Ser Gly Glu Lys Val Leu Glu Thr Leu Gln Glu 
65                  70                  75                  80  


Lys Gly Glu Arg Thr Asn Pro Asn His Pro Thr Leu Trp Arg Pro Glu 
                85                  90                  95      


Tyr Gly Ser Tyr Met Ile Glu Gly Thr Pro Gly Gln Pro Tyr Gly Gly 
            100                 105                 110         


Thr Met Ser Glu Phe Asn Thr Val Glu Ala Asn Met Arg Lys Arg Arg 
        115                 120                 125             


Lys Glu Ala Thr Ser Ile Leu Glu Glu Asn Gln Ala Leu Cys Thr Ile 
    130                 135                 140                 


Thr Ser Phe Pro Arg Leu Gly Cys Pro Gly Phe Thr Leu Pro Glu Val 
145                 150                 155                 160 


Lys Pro Asn Pro Val Glu Gly Gly Ala Ser Lys Ser Leu Phe Phe Pro 
                165                 170                 175     


Asp Glu Ala Ile Asn Lys His Pro Arg Phe Ser Thr Leu Thr Arg Asn 
            180                 185                 190         


Ile Arg His Arg Arg Gly Glu Lys Val Val Ile Asn Val Pro Ile Phe 
        195                 200                 205             


Lys Asp Lys Asn Thr Pro Ser Pro Phe Ile Glu Thr Phe Thr Glu Asp 
    210                 215                 220                 


Asp Glu Ala Ser Arg Ala Ser Lys Pro Asp His Ile Tyr Met Asp Ala 
225                 230                 235                 240 


Met Gly Phe Gly Met Gly Asn Cys Cys Leu Gln Val Thr Phe Gln Ala 
                245                 250                 255     


Cys Ser Ile Ser Glu Ala Arg Tyr Leu Tyr Asp Gln Leu Ala Thr Ile 
            260                 265                 270         


Cys Pro Ile Val Met Ala Leu Ser Ala Ala Ser Pro Phe Tyr Arg Gly 
        275                 280                 285             


Tyr Val Ser Asp Ile Asp Cys Arg Trp Gly Val Ile Ser Ala Ser Val 
    290                 295                 300                 


Asp Asp Arg Thr Arg Glu Glu Arg Gly Leu Glu Pro Leu Lys Asn Asn 
305                 310                 315                 320 


Asn Tyr Arg Ile Ser Lys Ser Arg Tyr Asp Ser Ile Asp Ser Tyr Leu 
                325                 330                 335     


Ser Lys Cys Gly Glu Lys Tyr Asn Asp Ile Asp Leu Thr Ile Asp Lys 
            340                 345                 350         


Glu Ile Tyr Glu Gln Leu Leu Gln Glu Gly Ile Asp His Leu Leu Ala 
        355                 360                 365             


Gln His Val Ala His Leu Phe Ile Arg Asp Pro Leu Thr Leu Phe Glu 
    370                 375                 380                 


Glu Lys Ile His Leu Asp Asp Ala Asn Glu Ser Asp His Phe Glu Asn 
385                 390                 395                 400 


Ile Gln Ser Thr Asn Trp Gln Thr Met Arg Phe Lys Pro Pro Pro Pro 
                405                 410                 415     


Asn Ser Asp Ile Gly Trp Arg Val Glu Phe Arg Pro Met Glu Val Gln 
            420                 425                 430         


Leu Thr Asp Phe Glu Asn Ser Ala Tyr Val Val Phe Val Val Leu Leu 
        435                 440                 445             


Thr Arg Val Ile Leu Ser Tyr Lys Leu Asp Phe Leu Ile Pro Leu Ser 
    450                 455                 460                 


Lys Val Asp Glu Asn Met Lys Val Ala Gln Lys Arg Asp Ala Val Leu 
465                 470                 475                 480 


Gln Gly Met Phe Tyr Phe Arg Lys Asp Ile Cys Lys Gly Gly Asn Ala 
                485                 490                 495     


Val Val Asp Gly Cys Gly Lys Ala Gln Asn Ser Thr Glu Leu Ala Ala 
            500                 505                 510         


Glu Glu Tyr Thr Leu Met Ser Ile Asp Thr Ile Ile Asn Gly Lys Glu 
        515                 520                 525             


Gly Val Phe Pro Gly Leu Ile Pro Ile Leu Asn Ser Tyr Leu Glu Asn 
    530                 535                 540                 


Met Glu Val Asp Val Asp Thr Arg Cys Ser Ile Leu Asn Tyr Leu Lys 
545                 550                 555                 560 


Leu Ile Lys Lys Arg Ala Ser Gly Glu Leu Met Thr Val Ala Arg Trp 
                565                 570                 575     


Met Arg Glu Phe Ile Ala Asn His Pro Asp Tyr Lys Gln Asp Ser Val 
            580                 585                 590         


Ile Thr Asp Glu Met Asn Tyr Ser Leu Ile Leu Lys Cys Asn Gln Ile 
        595                 600                 605             


Ala Asn Glu Leu Cys Glu Cys Pro Glu Leu Leu Gly Ser Ala Phe Arg 
    610                 615                 620                 


Lys Val Lys Tyr Ser Gly Ser Lys Thr Asp Ser Ser Asn 
625                 630                 635         


<210>  2392
<211>  534
<212>  PRT
<213>  Homo sapiens

<400>  2392

Met Pro His Leu Met Glu Arg Met Val Gly Ser Gly Leu Leu Trp Leu 
1               5                   10                  15      


Ala Leu Val Ser Cys Ile Leu Thr Gln Ala Ser Ala Val Gln Arg Gly 
            20                  25                  30          


Tyr Gly Asn Pro Ile Glu Ala Ser Ser Tyr Gly Leu Asp Leu Asp Cys 
        35                  40                  45              


Gly Ala Pro Gly Thr Pro Glu Ala His Val Cys Phe Asp Pro Cys Gln 
    50                  55                  60                  


Asn Tyr Thr Leu Leu Asp Glu Pro Phe Arg Ser Thr Glu Asn Ser Ala 
65                  70                  75                  80  


Gly Ser Gln Gly Cys Asp Lys Asn Met Ser Gly Trp Tyr Arg Phe Val 
                85                  90                  95      


Gly Glu Gly Gly Val Arg Met Ser Glu Thr Cys Val Gln Val His Arg 
            100                 105                 110         


Cys Gln Thr Asp Ala Pro Met Trp Leu Asn Gly Thr His Pro Ala Leu 
        115                 120                 125             


Gly Asp Gly Ile Thr Asn His Thr Ala Cys Ala His Trp Ser Gly Asn 
    130                 135                 140                 


Cys Cys Phe Trp Lys Thr Glu Val Leu Val Lys Ala Cys Pro Gly Gly 
145                 150                 155                 160 


Tyr His Val Tyr Arg Leu Glu Gly Thr Pro Trp Cys Asn Leu Arg Tyr 
                165                 170                 175     


Cys Thr Asp Pro Ser Thr Val Glu Asp Lys Cys Glu Lys Ala Cys Arg 
            180                 185                 190         


Pro Glu Glu Glu Cys Leu Ala Leu Asn Ser Thr Trp Gly Cys Phe Cys 
        195                 200                 205             


Arg Gln Asp Leu Asn Ser Ser Asp Val His Ser Leu Gln Pro Gln Leu 
    210                 215                 220                 


Asp Cys Gly Pro Arg Glu Ile Lys Val Lys Val Asp Lys Cys Leu Leu 
225                 230                 235                 240 


Gly Gly Leu Gly Leu Gly Glu Glu Val Ile Ala Tyr Leu Arg Asp Pro 
                245                 250                 255     


Asn Cys Ser Ser Ile Leu Gln Thr Glu Glu Arg Asn Trp Val Ser Val 
            260                 265                 270         


Thr Ser Pro Val Gln Ala Ser Ala Cys Arg Asn Ile Leu Glu Arg Asn 
        275                 280                 285             


Gln Thr His Ala Ile Tyr Lys Asn Thr Leu Ser Leu Val Asn Asp Phe 
    290                 295                 300                 


Ile Ile Arg Asp Thr Ile Leu Asn Ile Asn Phe Gln Cys Ala Tyr Pro 
305                 310                 315                 320 


Leu Asp Met Lys Val Ser Leu Gln Ala Ala Leu Gln Pro Ile Val Ser 
                325                 330                 335     


Ser Leu Asn Val Ser Val Asp Gly Asn Gly Glu Phe Ile Val Arg Met 
            340                 345                 350         


Ala Leu Phe Gln Asp Gln Asn Tyr Thr Asn Pro Tyr Glu Gly Asp Ala 
        355                 360                 365             


Val Glu Leu Ser Val Glu Ser Val Leu Tyr Val Gly Ala Ile Leu Glu 
    370                 375                 380                 


Gln Gly Asp Thr Ser Arg Phe Asn Leu Val Leu Arg Asn Cys Tyr Ala 
385                 390                 395                 400 


Thr Pro Thr Glu Asp Lys Ala Asp Leu Val Lys Tyr Phe Ile Ile Arg 
                405                 410                 415     


Asn Ser Cys Ser Asn Gln Arg Asp Ser Thr Ile His Val Glu Glu Asn 
            420                 425                 430         


Gly Gln Ser Ser Glu Ser Arg Phe Ser Val Gln Met Phe Met Phe Ala 
        435                 440                 445             


Gly His Tyr Asp Leu Val Phe Leu His Cys Glu Ile His Leu Cys Asp 
    450                 455                 460                 


Ser Leu Asn Glu Gln Cys Gln Pro Ser Cys Ser Arg Ser Gln Val Arg 
465                 470                 475                 480 


Ser Glu Val Pro Ala Ile Asp Leu Ala Arg Val Leu Asp Leu Gly Pro 
                485                 490                 495     


Ile Thr Arg Arg Gly Ala Gln Ser Pro Gly Val Met Asn Gly Thr Pro 
            500                 505                 510         


Ser Thr Ala Gly Phe Leu Val Ala Trp Pro Met Val Leu Leu Thr Val 
        515                 520                 525             


Leu Leu Ala Trp Leu Phe 
    530                 


<210>  2393
<211>  368
<212>  PRT
<213>  Homo sapiens

<400>  2393

Met Val Leu Glu Val Ser Asp His Gln Val Leu Asn Asp Ala Glu Val 
1               5                   10                  15      


Ala Ala Leu Leu Glu Asn Phe Ser Ser Ser Tyr Asp Tyr Gly Glu Asn 
            20                  25                  30          


Glu Ser Asp Ser Cys Cys Thr Ser Pro Pro Cys Pro Gln Asp Phe Ser 
        35                  40                  45              


Leu Asn Phe Asp Arg Ala Phe Leu Pro Ala Leu Tyr Ser Leu Leu Phe 
    50                  55                  60                  


Leu Leu Gly Leu Leu Gly Asn Gly Ala Val Ala Ala Val Leu Leu Ser 
65                  70                  75                  80  


Arg Arg Thr Ala Leu Ser Ser Thr Asp Thr Phe Leu Leu His Leu Ala 
                85                  90                  95      


Val Ala Asp Thr Leu Leu Val Leu Thr Leu Pro Leu Trp Ala Val Asp 
            100                 105                 110         


Ala Ala Val Gln Trp Val Phe Gly Ser Gly Leu Cys Lys Val Ala Gly 
        115                 120                 125             


Ala Leu Phe Asn Ile Asn Phe Tyr Ala Gly Ala Leu Leu Leu Ala Cys 
    130                 135                 140                 


Ile Ser Phe Asp Arg Tyr Leu Asn Ile Val His Ala Thr Gln Leu Tyr 
145                 150                 155                 160 


Arg Arg Gly Pro Pro Ala Arg Val Thr Leu Thr Cys Leu Ala Val Trp 
                165                 170                 175     


Gly Leu Cys Leu Leu Phe Ala Leu Pro Asp Phe Ile Phe Leu Ser Ala 
            180                 185                 190         


His His Asp Glu Arg Leu Asn Ala Thr His Cys Gln Tyr Asn Phe Pro 
        195                 200                 205             


Gln Val Gly Arg Thr Ala Leu Arg Val Leu Gln Leu Val Ala Gly Phe 
    210                 215                 220                 


Leu Leu Pro Leu Leu Val Met Ala Tyr Cys Tyr Ala His Ile Leu Ala 
225                 230                 235                 240 


Val Leu Leu Val Ser Arg Gly Gln Arg Arg Leu Arg Ala Met Arg Leu 
                245                 250                 255     


Val Val Val Val Val Val Ala Phe Ala Leu Cys Trp Thr Pro Tyr His 
            260                 265                 270         


Leu Val Val Leu Val Asp Ile Leu Met Asp Leu Gly Ala Leu Ala Arg 
        275                 280                 285             


Asn Cys Gly Arg Glu Ser Arg Val Asp Val Ala Lys Ser Val Thr Ser 
    290                 295                 300                 


Gly Leu Gly Tyr Met His Cys Cys Leu Asn Pro Leu Leu Tyr Ala Phe 
305                 310                 315                 320 


Val Gly Val Lys Phe Arg Glu Arg Met Trp Met Leu Leu Leu Arg Leu 
                325                 330                 335     


Gly Cys Pro Asn Gln Arg Gly Leu Gln Arg Gln Pro Ser Ser Ser Arg 
            340                 345                 350         


Arg Asp Ser Ser Trp Ser Glu Thr Ser Glu Ala Ser Tyr Ser Gly Leu 
        355                 360                 365             


<210>  2394
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  2394

Met Asp Val Thr Ser Gln Ala Arg Gly Val Gly Leu Glu Met Tyr Pro 
1               5                   10                  15      


Gly Thr Ala Gln Pro Ala Ala Pro Asn Thr Thr Ser Pro Glu Leu Asn 
            20                  25                  30          


Leu Ser His Pro Leu Leu Gly Thr Ala Leu Ala Asn Gly Thr Gly Glu 
        35                  40                  45              


Leu Ser Glu His Gln Gln Tyr Val Ile Gly Leu Phe Leu Ser Cys Leu 
    50                  55                  60                  


Tyr Thr Ile Phe Leu Phe Pro Ile Gly Phe Val Gly Asn Ile Leu Ile 
65                  70                  75                  80  


Leu Val Val Asn Ile Ser Phe Arg Glu Lys Met Thr Ile Pro Asp Leu 
                85                  90                  95      


Tyr Phe Ile Asn Leu Ala Val Ala Asp Leu Ile Leu Val Ala Asp Ser 
            100                 105                 110         


Leu Ile Glu Val Phe Asn Leu His Glu Arg Tyr Tyr Asp Ile Ala Val 
        115                 120                 125             


Leu Cys Thr Phe Met Ser Leu Phe Leu Gln Val Asn Met Tyr Ser Ser 
    130                 135                 140                 


Val Phe Phe Leu Thr Trp Met Ser Phe Asp Arg Tyr Ile Ala Leu Ala 
145                 150                 155                 160 


Arg Ala Met Arg Cys Ser Leu Phe Arg Thr Lys His His Ala Arg Leu 
                165                 170                 175     


Ser Cys Gly Leu Ile Trp Met Ala Ser Val Ser Ala Thr Leu Val Pro 
            180                 185                 190         


Phe Thr Ala Val His Leu Gln His Thr Asp Glu Ala Cys Phe Cys Phe 
        195                 200                 205             


Ala Asp Val Arg Glu Val Gln Trp Leu Glu Val Thr Leu Gly Phe Ile 
    210                 215                 220                 


Val Pro Phe Ala Ile Ile Gly Leu Cys Tyr Ser Leu Ile Val Arg Val 
225                 230                 235                 240 


Leu Val Arg Ala His Arg His Arg Gly Leu Arg Pro Arg Arg Gln Lys 
                245                 250                 255     


Ala Leu Arg Met Ile Leu Ala Val Val Leu Val Phe Phe Val Cys Trp 
            260                 265                 270         


Leu Pro Glu Asn Val Phe Ile Ser Val His Leu Leu Gln Arg Thr Gln 
        275                 280                 285             


Pro Gly Ala Ala Pro Cys Lys Gln Ser Phe Arg His Ala His Pro Leu 
    290                 295                 300                 


Thr Gly His Ile Val Asn Leu Ala Ala Phe Ser Asn Ser Cys Leu Asn 
305                 310                 315                 320 


Pro Leu Ile Tyr Ser Phe Leu Gly Glu Thr Phe Arg Asp Lys Leu Arg 
                325                 330                 335     


Leu Tyr Ile Glu Gln Lys Thr Asn Leu Pro Ala Leu Asn Arg Phe Cys 
            340                 345                 350         


His Ala Ala Leu Lys Ala Val Ile Pro Asp Ser Thr Glu Gln Ser Asp 
        355                 360                 365             


Val Arg Phe Ser Ser Ala Val 
    370                 375 


<210>  2395
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  2395

Met Asn Gly Val Ser Glu Gly Thr Arg Gly Cys Ser Asp Arg Gln Pro 
1               5                   10                  15      


Gly Val Leu Thr Arg Asp Arg Ser Cys Ser Arg Lys Met Asn Ser Ser 
            20                  25                  30          


Gly Cys Leu Ser Glu Glu Val Gly Ser Leu Arg Pro Leu Thr Val Val 
        35                  40                  45              


Ile Leu Ser Ala Ser Ile Val Val Gly Val Leu Gly Asn Gly Leu Val 
    50                  55                  60                  


Leu Trp Met Thr Val Phe Arg Met Ala Arg Thr Val Ser Thr Val Cys 
65                  70                  75                  80  


Phe Phe His Leu Ala Leu Ala Asp Phe Met Leu Ser Leu Ser Leu Pro 
                85                  90                  95      


Ile Ala Met Tyr Tyr Ile Val Ser Arg Gln Trp Leu Leu Gly Glu Trp 
            100                 105                 110         


Ala Cys Lys Leu Tyr Ile Thr Phe Val Phe Leu Ser Tyr Phe Ala Ser 
        115                 120                 125             


Asn Cys Leu Leu Val Phe Ile Ser Val Asp Arg Cys Ile Ser Val Leu 
    130                 135                 140                 


Tyr Pro Val Trp Ala Leu Asn His Arg Thr Val Gln Arg Ala Ser Trp 
145                 150                 155                 160 


Leu Ala Phe Gly Val Trp Leu Leu Ala Ala Ala Leu Cys Ser Ala His 
                165                 170                 175     


Leu Lys Phe Arg Thr Thr Arg Lys Trp Asn Gly Cys Thr His Cys Tyr 
            180                 185                 190         


Leu Ala Phe Asn Ser Asp Asn Glu Thr Ala Gln Ile Trp Ile Glu Gly 
        195                 200                 205             


Val Val Glu Gly His Ile Ile Gly Thr Ile Gly His Phe Leu Leu Gly 
    210                 215                 220                 


Phe Leu Gly Pro Leu Ala Ile Ile Gly Thr Cys Ala His Leu Ile Arg 
225                 230                 235                 240 


Ala Lys Leu Leu Arg Glu Gly Trp Val His Ala Asn Arg Pro Lys Arg 
                245                 250                 255     


Leu Leu Leu Val Leu Val Ser Ala Phe Phe Ile Phe Trp Ser Pro Phe 
            260                 265                 270         


Asn Val Val Leu Leu Val His Leu Trp Arg Arg Val Met Leu Lys Glu 
        275                 280                 285             


Ile Tyr His Pro Arg Met Leu Leu Ile Leu Gln Ala Ser Phe Ala Leu 
    290                 295                 300                 


Gly Cys Val Asn Ser Ser Leu Asn Pro Phe Leu Tyr Val Phe Val Gly 
305                 310                 315                 320 


Arg Asp Phe Gln Glu Lys Phe Phe Gln Ser Leu Thr Ser Ala Leu Ala 
                325                 330                 335     


Arg Ala Phe Gly Glu Glu Glu Phe Leu Ser Ser Cys Pro Arg Gly Asn 
            340                 345                 350         


Ala Pro Arg Glu 
        355     


<210>  2396
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  2396

Met Gly Ser Pro Trp Asn Gly Ser Asp Gly Pro Glu Gly Ala Arg Glu 
1               5                   10                  15      


Pro Pro Trp Pro Ala Leu Pro Pro Cys Asp Glu Arg Arg Cys Ser Pro 
            20                  25                  30          


Phe Pro Leu Gly Ala Leu Val Pro Val Thr Ala Val Cys Leu Cys Leu 
        35                  40                  45              


Phe Val Val Gly Val Ser Gly Asn Val Val Thr Val Met Leu Ile Gly 
    50                  55                  60                  


Arg Tyr Arg Asp Met Arg Thr Thr Thr Asn Leu Tyr Leu Gly Ser Met 
65                  70                  75                  80  


Ala Val Ser Asp Leu Leu Ile Leu Leu Gly Leu Pro Phe Asp Leu Tyr 
                85                  90                  95      


Arg Leu Trp Arg Ser Arg Pro Trp Val Phe Gly Pro Leu Leu Cys Arg 
            100                 105                 110         


Leu Ser Leu Tyr Val Gly Glu Gly Cys Thr Tyr Ala Thr Leu Leu His 
        115                 120                 125             


Met Thr Ala Leu Ser Val Glu Arg Tyr Leu Ala Ile Cys Arg Pro Leu 
    130                 135                 140                 


Arg Ala Arg Val Leu Val Thr Arg Arg Arg Val Arg Ala Leu Ile Ala 
145                 150                 155                 160 


Val Leu Trp Ala Val Ala Leu Leu Ser Ala Gly Pro Phe Leu Phe Leu 
                165                 170                 175     


Val Gly Val Glu Gln Asp Pro Gly Ile Ser Val Val Pro Gly Leu Asn 
            180                 185                 190         


Gly Thr Ala Arg Ile Ala Ser Ser Pro Leu Ala Ser Ser Pro Pro Leu 
        195                 200                 205             


Trp Leu Ser Arg Ala Pro Pro Pro Ser Pro Pro Ser Gly Pro Glu Thr 
    210                 215                 220                 


Ala Glu Ala Ala Ala Leu Phe Ser Arg Glu Cys Arg Pro Ser Pro Ala 
225                 230                 235                 240 


Gln Leu Gly Ala Leu Arg Val Met Leu Trp Val Thr Thr Ala Tyr Phe 
                245                 250                 255     


Phe Leu Pro Phe Leu Cys Leu Ser Ile Leu Tyr Gly Leu Ile Gly Arg 
            260                 265                 270         


Glu Leu Trp Ser Ser Arg Arg Pro Leu Arg Gly Pro Ala Ala Ser Gly 
        275                 280                 285             


Arg Glu Arg Gly His Arg Gln Thr Val Arg Val Leu Leu Val Val Val 
    290                 295                 300                 


Leu Ala Phe Ile Ile Cys Trp Leu Pro Phe His Val Gly Arg Ile Ile 
305                 310                 315                 320 


Tyr Ile Asn Thr Glu Asp Ser Arg Met Met Tyr Phe Ser Gln Tyr Phe 
                325                 330                 335     


Asn Ile Val Ala Leu Gln Leu Phe Tyr Leu Ser Ala Ser Ile Asn Pro 
            340                 345                 350         


Ile Leu Tyr Asn Leu Ile Ser Lys Lys Tyr Arg Ala Ala Ala Phe Lys 
        355                 360                 365             


Leu Leu Leu Ala Arg Lys Ser Arg Pro Arg Gly Phe His Arg Ser Arg 
    370                 375                 380                 


Asp Thr Ala Gly Glu Val Ala Gly Asp Thr Gly Gly Asp Thr Val Gly 
385                 390                 395                 400 


Tyr Thr Glu Thr Ser Ala Asn Val Lys Thr Met Gly 
                405                 410         


<210>  2397
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  2397

Met Ala Ser Pro Ser Leu Pro Gly Ser Asp Cys Ser Gln Ile Ile Asp 
1               5                   10                  15      


His Ser His Val Pro Glu Phe Glu Val Ala Thr Trp Ile Lys Ile Thr 
            20                  25                  30          


Leu Ile Leu Val Tyr Leu Ile Ile Phe Val Met Gly Leu Leu Gly Asn 
        35                  40                  45              


Ser Ala Thr Ile Arg Val Thr Gln Val Leu Gln Lys Lys Gly Tyr Leu 
    50                  55                  60                  


Gln Lys Glu Val Thr Asp His Met Val Ser Leu Ala Cys Ser Asp Ile 
65                  70                  75                  80  


Leu Val Phe Leu Ile Gly Met Pro Met Glu Phe Tyr Ser Ile Ile Trp 
                85                  90                  95      


Asn Pro Leu Thr Thr Ser Ser Tyr Thr Leu Ser Cys Lys Leu His Thr 
            100                 105                 110         


Phe Leu Phe Glu Ala Cys Ser Tyr Ala Thr Leu Leu His Val Leu Thr 
        115                 120                 125             


Leu Ser Phe Glu Arg Tyr Ile Ala Ile Cys His Pro Phe Arg Tyr Lys 
    130                 135                 140                 


Ala Val Ser Gly Pro Cys Gln Val Lys Leu Leu Ile Gly Phe Val Trp 
145                 150                 155                 160 


Val Thr Ser Ala Leu Val Ala Leu Pro Leu Leu Phe Ala Met Gly Thr 
                165                 170                 175     


Glu Tyr Pro Leu Val Asn Val Pro Ser His Arg Gly Leu Thr Cys Asn 
            180                 185                 190         


Arg Ser Ser Thr Arg His His Glu Gln Pro Glu Thr Ser Asn Met Ser 
        195                 200                 205             


Ile Cys Thr Asn Leu Ser Ser Arg Trp Thr Val Phe Gln Ser Ser Ile 
    210                 215                 220                 


Phe Gly Ala Phe Val Val Tyr Leu Val Val Leu Leu Ser Val Ala Phe 
225                 230                 235                 240 


Met Cys Trp Asn Met Met Gln Val Leu Met Lys Ser Gln Lys Gly Ser 
                245                 250                 255     


Leu Ala Gly Gly Thr Arg Pro Pro Gln Leu Arg Lys Ser Glu Ser Glu 
            260                 265                 270         


Glu Ser Arg Thr Ala Arg Arg Gln Thr Ile Ile Phe Leu Arg Leu Ile 
        275                 280                 285             


Val Val Thr Leu Ala Val Cys Trp Met Pro Asn Gln Ile Arg Arg Ile 
    290                 295                 300                 


Met Ala Ala Ala Lys Pro Lys His Asp Trp Thr Arg Ser Tyr Phe Arg 
305                 310                 315                 320 


Ala Tyr Met Ile Leu Leu Pro Phe Ser Glu Thr Phe Phe Tyr Leu Ser 
                325                 330                 335     


Ser Val Ile Asn Pro Leu Leu Tyr Thr Val Ser Ser Gln Gln Phe Arg 
            340                 345                 350         


Arg Val Phe Val Gln Val Leu Cys Cys Arg Leu Ser Leu Gln His Ala 
        355                 360                 365             


Asn His Glu Lys Arg Leu Arg Val His Ala His Ser Thr Thr Asp Ser 
    370                 375                 380                 


Ala Arg Phe Val Gln Arg Pro Leu Leu Phe Ala Ser Arg Arg Gln Ser 
385                 390                 395                 400 


Ser Ala Arg Arg Thr Glu Lys Ile Phe Leu Ser Thr Phe Gln Ser Glu 
                405                 410                 415     


Ala Glu Pro Gln Ser Lys Ser Gln Ser Leu Ser Leu Glu Ser Leu Glu 
            420                 425                 430         


Pro Asn Ser Gly Ala Lys Pro Ala Asn Ser Ala Ala Glu Asn Gly Phe 
        435                 440                 445             


Gln Glu His Glu Val 
    450             


<210>  2398
<211>  1007
<212>  PRT
<213>  Homo sapiens

<400>  2398

Met Glu Val Phe Pro Phe Leu Leu Val Leu Ser Val Trp Trp Ser Arg 
1               5                   10                  15      


Thr Trp Asp Ser Ala Asn Ala Asp Ser Ile Ile His Ile Gly Ala Ile 
            20                  25                  30          


Phe Asp Glu Ser Ala Lys Lys Asp Asp Glu Val Phe Arg Thr Ala Val 
        35                  40                  45              


Gly Asp Leu Asn Gln Asn Glu Glu Ile Leu Gln Thr Glu Lys Ile Thr 
    50                  55                  60                  


Phe Ser Val Thr Phe Val Asp Gly Asn Asn Pro Phe Gln Ala Val Gln 
65                  70                  75                  80  


Glu Ala Cys Glu Leu Met Asn Gln Gly Ile Leu Ala Leu Val Ser Ser 
                85                  90                  95      


Ile Gly Cys Thr Ser Ala Gly Ser Leu Gln Ser Leu Ala Asp Ala Met 
            100                 105                 110         


His Ile Pro His Leu Phe Ile Gln Arg Ser Thr Ala Gly Thr Pro Arg 
        115                 120                 125             


Ser Gly Cys Gly Leu Thr Arg Ser Asn Arg Asn Asp Asp Tyr Thr Leu 
    130                 135                 140                 


Ser Val Arg Pro Pro Val Tyr Leu His Asp Val Ile Leu Arg Val Val 
145                 150                 155                 160 


Thr Glu Tyr Ala Trp Gln Lys Phe Ile Ile Phe Tyr Asp Ser Glu Tyr 
                165                 170                 175     


Asp Ile Arg Gly Ile Gln Glu Phe Leu Asp Lys Val Ser Gln Gln Gly 
            180                 185                 190         


Met Asp Val Ala Leu Gln Lys Val Glu Asn Asn Ile Asn Lys Met Ile 
        195                 200                 205             


Thr Thr Leu Phe Asp Thr Met Arg Ile Glu Glu Leu Asn Arg Tyr Arg 
    210                 215                 220                 


Asp Thr Leu Arg Arg Ala Ile Leu Val Met Asn Pro Ala Thr Ala Lys 
225                 230                 235                 240 


Ser Phe Ile Thr Glu Val Val Glu Thr Asn Leu Val Ala Phe Asp Cys 
                245                 250                 255     


His Trp Ile Ile Ile Asn Glu Glu Ile Asn Asp Val Asp Val Gln Glu 
            260                 265                 270         


Leu Val Arg Arg Ser Ile Gly Arg Leu Thr Ile Ile Arg Gln Thr Phe 
        275                 280                 285             


Pro Val Pro Gln Asn Ile Ser Gln Arg Cys Phe Arg Gly Asn His Arg 
    290                 295                 300                 


Ile Ser Ser Thr Leu Cys Asp Pro Lys Asp Pro Phe Ala Gln Asn Met 
305                 310                 315                 320 


Glu Ile Ser Asn Leu Tyr Ile Tyr Asp Thr Val Leu Leu Leu Ala Asn 
                325                 330                 335     


Ala Phe His Lys Lys Leu Glu Asp Arg Lys Trp His Ser Met Ala Ser 
            340                 345                 350         


Leu Ser Cys Ile Arg Lys Asn Ser Lys Pro Trp Gln Gly Gly Arg Ser 
        355                 360                 365             


Met Leu Glu Thr Ile Lys Lys Gly Gly Val Ser Gly Leu Thr Gly Glu 
    370                 375                 380                 


Leu Glu Phe Gly Glu Asn Gly Gly Asn Pro Asn Val His Phe Glu Ile 
385                 390                 395                 400 


Leu Gly Thr Asn Tyr Gly Glu Glu Leu Gly Arg Gly Val Arg Lys Leu 
                405                 410                 415     


Gly Cys Trp Asn Pro Val Thr Gly Leu Asn Gly Ser Leu Thr Asp Lys 
            420                 425                 430         


Lys Leu Glu Asn Asn Met Arg Gly Val Val Leu Arg Val Val Thr Val 
        435                 440                 445             


Leu Glu Glu Pro Phe Val Met Val Ser Glu Asn Val Leu Gly Lys Pro 
    450                 455                 460                 


Lys Lys Tyr Gln Gly Phe Ser Ile Asp Val Leu Asp Ala Leu Ser Asn 
465                 470                 475                 480 


Tyr Leu Gly Phe Asn Tyr Glu Ile Tyr Val Ala Pro Asp His Lys Tyr 
                485                 490                 495     


Gly Ser Pro Gln Glu Asp Gly Thr Trp Asn Gly Leu Val Gly Glu Leu 
            500                 505                 510         


Val Phe Lys Arg Ala Asp Ile Gly Ile Ser Ala Leu Thr Ile Thr Pro 
        515                 520                 525             


Asp Arg Glu Asn Val Val Asp Phe Thr Thr Arg Tyr Met Asp Tyr Ser 
    530                 535                 540                 


Val Gly Val Leu Leu Arg Arg Ala Glu Lys Thr Val Asp Met Phe Ala 
545                 550                 555                 560 


Cys Leu Ala Pro Phe Asp Leu Ser Leu Trp Ala Cys Ile Ala Gly Thr 
                565                 570                 575     


Val Leu Leu Val Gly Leu Leu Val Tyr Leu Leu Asn Trp Leu Asn Pro 
            580                 585                 590         


Pro Arg Leu Gln Met Gly Ser Met Thr Ser Thr Thr Leu Tyr Asn Ser 
        595                 600                 605             


Met Trp Phe Val Tyr Gly Ser Phe Val Gln Gln Gly Gly Glu Val Pro 
    610                 615                 620                 


Tyr Thr Thr Leu Ala Thr Arg Met Met Met Gly Ala Trp Trp Leu Phe 
625                 630                 635                 640 


Ala Leu Ile Val Ile Ser Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu 
                645                 650                 655     


Thr Ile Thr Arg Ile Glu Ser Ser Ile Gln Ser Leu Gln Asp Leu Ser 
            660                 665                 670         


Lys Gln Thr Glu Ile Pro Tyr Gly Thr Val Leu Asp Ser Ala Val Tyr 
        675                 680                 685             


Glu His Val Arg Met Lys Gly Leu Asn Pro Phe Glu Arg Asp Ser Met 
    690                 695                 700                 


Tyr Ser Gln Met Trp Arg Met Ile Asn Arg Ser Asn Gly Ser Glu Asn 
705                 710                 715                 720 


Asn Val Leu Glu Ser Gln Ala Gly Ile Gln Lys Val Lys Tyr Gly Asn 
                725                 730                 735     


Tyr Ala Phe Val Trp Asp Ala Ala Val Leu Glu Tyr Val Ala Ile Asn 
            740                 745                 750         


Asp Pro Asp Cys Ser Phe Tyr Thr Ile Gly Asn Thr Val Ala Asp Arg 
        755                 760                 765             


Gly Tyr Gly Ile Ala Leu Gln His Gly Ser Pro Tyr Arg Asp Val Phe 
    770                 775                 780                 


Ser Gln Arg Ile Leu Glu Leu Gln Gln Asn Gly Asp Met Asp Ile Leu 
785                 790                 795                 800 


Lys His Lys Trp Trp Pro Lys Asn Gly Gln Cys Asp Leu Tyr Ser Ser 
                805                 810                 815     


Val Asp Thr Lys Gln Lys Gly Gly Ala Leu Asp Ile Lys Ser Phe Ala 
            820                 825                 830         


Gly Val Phe Cys Ile Leu Ala Ala Gly Ile Val Leu Ser Cys Phe Ile 
        835                 840                 845             


Ala Met Leu Glu Thr Trp Trp Asn Lys Arg Lys Gly Ser Arg Val Pro 
    850                 855                 860                 


Ser Lys Glu Asp Asp Lys Glu Ile Asp Leu Glu His Leu His Arg Arg 
865                 870                 875                 880 


Val Asn Ser Leu Cys Thr Asp Asp Asp Ser Pro His Lys Gln Phe Ser 
                885                 890                 895     


Thr Ser Ser Ile Asp Leu Thr Pro Leu Asp Ile Asp Thr Leu Pro Thr 
            900                 905                 910         


Arg Gln Ala Leu Glu Gln Ile Ser Asp Phe Arg Asn Thr His Ile Thr 
        915                 920                 925             


Thr Thr Thr Phe Ile Pro Glu Gln Ile Gln Thr Leu Ser Arg Thr Leu 
    930                 935                 940                 


Ser Ala Lys Ala Ala Ser Gly Phe Thr Phe Gly Asn Val Pro Glu His 
945                 950                 955                 960 


Arg Thr Gly Pro Phe Arg His Arg Ala Pro Asn Gly Gly Phe Phe Arg 
                965                 970                 975     


Ser Pro Ile Lys Thr Met Ser Ser Ile Pro Tyr Gln Pro Thr Pro Thr 
            980                 985                 990         


Leu Gly Leu Asn Leu Gly Asn Asp  Pro Asp Arg Gly Thr  Ser Ile 
        995                 1000                 1005         


<210>  2399
<211>  1108
<212>  PRT
<213>  Homo sapiens

<400>  2399

Met Phe Leu Gly Leu Gly Arg Phe Ser Arg Leu Val Leu Trp Phe Ala 
1               5                   10                  15      


Ala Phe Arg Lys Leu Leu Gly His His Gly Leu Ala Ser Ala Lys Phe 
            20                  25                  30          


Leu Trp Cys Leu Cys Leu Leu Ser Val Met Ser Leu Pro Gln Gln Val 
        35                  40                  45              


Trp Thr Leu Pro Tyr Lys Ile Gly Val Val Gly Pro Trp Ala Cys Asp 
    50                  55                  60                  


Ser Leu Phe Ser Lys Ala Leu Pro Glu Val Ala Ala Arg Leu Ala Ile 
65                  70                  75                  80  


Glu Arg Ile Asn Arg Asp Pro Ser Phe Asp Leu Ser Tyr Ser Phe Glu 
                85                  90                  95      


Tyr Val Ile Leu Asn Glu Asp Cys Gln Thr Ser Arg Ala Leu Ser Ser 
            100                 105                 110         


Phe Ile Ser His His Gln Met Ala Ser Gly Phe Ile Gly Pro Thr Asn 
        115                 120                 125             


Pro Gly Tyr Cys Glu Ala Ala Ser Leu Leu Gly Asn Ser Trp Asp Lys 
    130                 135                 140                 


Gly Ile Phe Ser Trp Ala Cys Val Asn Tyr Glu Leu Asp Asn Lys Ile 
145                 150                 155                 160 


Ser Tyr Pro Thr Phe Ser Arg Thr Leu Pro Ser Pro Ile Arg Val Leu 
                165                 170                 175     


Val Thr Val Met Lys Tyr Phe Gln Trp Ala His Ala Gly Val Ile Ser 
            180                 185                 190         


Ser Asp Glu Asp Ile Trp Val His Thr Ala Asn Arg Val Ala Ser Ala 
        195                 200                 205             


Leu Arg Ser His Gly Leu Pro Val Gly Val Val Leu Thr Thr Gly Gln 
    210                 215                 220                 


Asp Ser Gln Ser Met Arg Lys Ala Leu Gln Arg Ile His Gln Ala Asp 
225                 230                 235                 240 


Arg Ile Arg Ile Ile Ile Met Cys Met His Ser Ala Leu Ile Gly Gly 
                245                 250                 255     


Glu Thr Gln Met His Leu Leu Glu Cys Ala His Asp Leu Lys Met Thr 
            260                 265                 270         


Asp Gly Thr Tyr Val Phe Val Pro Tyr Asp Ala Leu Leu Tyr Ser Leu 
        275                 280                 285             


Pro Tyr Lys His Thr Pro Tyr Arg Val Leu Arg Asn Asn Pro Lys Leu 
    290                 295                 300                 


Arg Glu Ala Tyr Asp Ala Val Leu Thr Ile Thr Val Glu Ser Gln Glu 
305                 310                 315                 320 


Lys Thr Phe Tyr Gln Ala Phe Thr Glu Ala Ala Ala Arg Gly Glu Ile 
                325                 330                 335     


Pro Glu Lys Leu Glu Phe Asp Gln Val Ser Pro Leu Phe Gly Thr Ile 
            340                 345                 350         


Tyr Asn Ser Ile Tyr Phe Ile Ala Gln Ala Met Asn Asn Ala Met Lys 
        355                 360                 365             


Glu Asn Gly Gln Ala Gly Ala Ala Ser Leu Val Gln His Ser Arg Asn 
    370                 375                 380                 


Met Gln Phe His Gly Phe Asn Gln Leu Met Arg Thr Asp Ser Asn Gly 
385                 390                 395                 400 


Asn Gly Ile Ser Glu Tyr Val Ile Leu Asp Thr Asn Leu Lys Glu Trp 
                405                 410                 415     


Glu Leu His Ser Thr Tyr Thr Val Asp Met Glu Met Glu Leu Leu Arg 
            420                 425                 430         


Phe Gly Gly Thr Pro Ile His Phe Pro Gly Gly Arg Pro Pro Arg Ala 
        435                 440                 445             


Asp Ala Lys Cys Trp Phe Ala Glu Gly Lys Ile Cys His Gly Gly Ile 
    450                 455                 460                 


Asp Pro Ala Phe Ala Met Met Val Cys Leu Thr Leu Leu Ile Ala Leu 
465                 470                 475                 480 


Leu Ser Ile Asn Gly Phe Ala Tyr Phe Ile Arg Arg Arg Ile Asn Lys 
                485                 490                 495     


Ile Gln Leu Ile Lys Gly Pro Asn Arg Ile Leu Leu Thr Leu Glu Asp 
            500                 505                 510         


Val Thr Phe Ile Asn Pro His Phe Gly Ser Lys Arg Gly Ser Arg Ala 
        515                 520                 525             


Ser Val Ser Phe Gln Ile Thr Ser Glu Val Gln Ser Gly Arg Ser Pro 
    530                 535                 540                 


Arg Leu Ser Phe Ser Ser Gly Ser Leu Thr Pro Ala Thr Tyr Glu Asn 
545                 550                 555                 560 


Ser Asn Ile Ala Ile Tyr Glu Gly Asp Trp Val Trp Leu Lys Lys Phe 
                565                 570                 575     


Ser Leu Gly Asp Phe Gly Asp Leu Lys Ser Ile Lys Ser Arg Ala Ser 
            580                 585                 590         


Asp Val Phe Glu Met Met Lys Asp Leu Arg His Glu Asn Ile Asn Pro 
        595                 600                 605             


Leu Leu Gly Phe Phe Tyr Asp Ser Gly Met Phe Ala Ile Val Thr Glu 
    610                 615                 620                 


Phe Cys Ser Arg Gly Ser Leu Glu Asp Ile Leu Thr Asn Gln Asp Val 
625                 630                 635                 640 


Lys Leu Asp Trp Met Phe Lys Ser Ser Leu Leu Leu Asp Leu Ile Lys 
                645                 650                 655     


Gly Met Lys Tyr Leu His His Arg Glu Phe Val His Gly Arg Leu Lys 
            660                 665                 670         


Ser Arg Asn Cys Val Val Asp Gly Arg Phe Val Leu Lys Val Thr Asp 
        675                 680                 685             


Tyr Gly Phe Asn Asp Ile Leu Glu Met Leu Arg Leu Ser Glu Glu Glu 
    690                 695                 700                 


Ser Ser Met Glu Glu Leu Leu Trp Thr Ala Pro Glu Leu Leu Arg Ala 
705                 710                 715                 720 


Pro Arg Gly Ser Arg Leu Gly Ser Phe Ala Gly Asp Val Tyr Ser Phe 
                725                 730                 735     


Ala Ile Ile Met Gln Glu Val Met Val Arg Gly Thr Pro Phe Cys Met 
            740                 745                 750         


Met Asp Leu Pro Ala Gln Glu Ile Ile Asn Arg Leu Lys Lys Pro Pro 
        755                 760                 765             


Pro Val Tyr Arg Pro Val Val Pro Pro Glu His Ala Pro Pro Glu Cys 
    770                 775                 780                 


Leu Gln Leu Met Lys Gln Cys Trp Ala Glu Ala Ala Glu Gln Arg Pro 
785                 790                 795                 800 


Thr Phe Asp Glu Ile Phe Asn Gln Phe Lys Thr Phe Asn Lys Gly Lys 
                805                 810                 815     


Lys Thr Asn Ile Ile Asp Ser Met Leu Arg Met Leu Glu Gln Tyr Ser 
            820                 825                 830         


Ser Asn Leu Glu Asp Leu Ile Arg Glu Arg Thr Glu Glu Leu Glu Ile 
        835                 840                 845             


Glu Lys Gln Lys Thr Glu Lys Leu Leu Thr Gln Met Leu Pro Pro Ser 
    850                 855                 860                 


Val Ala Glu Ser Leu Lys Lys Gly Cys Thr Val Glu Pro Glu Gly Phe 
865                 870                 875                 880 


Asp Leu Val Thr Leu Tyr Phe Ser Asp Ile Val Gly Phe Thr Thr Ile 
                885                 890                 895     


Ser Ala Met Ser Glu Pro Ile Glu Val Val Asp Leu Leu Asn Asp Leu 
            900                 905                 910         


Tyr Thr Leu Phe Asp Ala Ile Ile Gly Ser His Asp Val Tyr Lys Val 
        915                 920                 925             


Glu Thr Ile Gly Asp Ala Tyr Met Val Ala Ser Gly Leu Pro Lys Arg 
    930                 935                 940                 


Asn Gly Ser Arg His Ala Ala Glu Ile Ala Asn Met Ser Leu Asp Ile 
945                 950                 955                 960 


Leu Ser Ser Val Gly Thr Phe Lys Met Arg His Met Pro Glu Val Pro 
                965                 970                 975     


Val Arg Ile Arg Ile Gly Leu His Ser Gly Pro Val Val Ala Gly Val 
            980                 985                 990         


Val Gly Leu Thr Met Pro Arg Tyr  Cys Leu Phe Gly Asp  Thr Val Asn 
        995                 1000                 1005             


Thr Ala  Ser Arg Met Glu Ser  Thr Gly Leu Pro Tyr  Arg Ile His 
    1010                 1015                 1020             


Val Ser  Leu Ser Thr Val Thr  Ile Leu Gln Asn Leu  Ser Glu Gly 
    1025                 1030                 1035             


Tyr Glu  Val Glu Leu Arg Gly  Arg Thr Glu Leu Lys  Gly Lys Gly 
    1040                 1045                 1050             


Thr Glu  Glu Thr Phe Trp Leu  Ile Gly Lys Lys Gly  Phe Met Lys 
    1055                 1060                 1065             


Pro Leu  Pro Val Pro Pro Pro  Val Asp Lys Asp Gly  Gln Val Gly 
    1070                 1075                 1080             


His Gly  Leu Gln Pro Val Glu  Ile Ala Ala Phe Gln  Arg Arg Lys 
    1085                 1090                 1095             


Ala Glu  Arg Gln Leu Val Arg  Asn Lys Pro 
    1100                 1105             


<210>  2400
<211>  578
<212>  PRT
<213>  Homo sapiens

<400>  2400

Met Arg Gln Gln Asp Ala Pro Lys Pro Thr Pro Ala Ala Cys Arg Cys 
1               5                   10                  15      


Ser Gly Leu Ala Arg Arg Val Leu Thr Ile Ala Phe Ala Leu Leu Ile 
            20                  25                  30          


Leu Gly Leu Met Thr Trp Ala Tyr Ala Ala Gly Val Pro Leu Ala Ser 
        35                  40                  45              


Asp Arg Tyr Gly Leu Leu Ala Phe Gly Leu Tyr Gly Ala Phe Leu Ser 
    50                  55                  60                  


Ala His Leu Val Ala Gln Ser Leu Phe Ala Tyr Leu Glu His Arg Arg 
65                  70                  75                  80  


Val Ala Ala Ala Ala Arg Gly Pro Leu Asp Ala Ala Thr Ala Arg Ser 
                85                  90                  95      


Val Ala Leu Thr Ile Ser Ala Tyr Gln Glu Asp Pro Ala Tyr Leu Arg 
            100                 105                 110         


Gln Cys Leu Ala Ser Ala Arg Ala Leu Leu Tyr Pro Arg Ala Arg Leu 
        115                 120                 125             


Arg Val Leu Met Val Val Asp Gly Asn Arg Ala Glu Asp Leu Tyr Met 
    130                 135                 140                 


Val Asp Met Phe Arg Glu Val Phe Ala Asp Glu Asp Pro Ala Thr Tyr 
145                 150                 155                 160 


Val Trp Asp Gly Asn Tyr His Gln Pro Trp Glu Pro Ala Ala Ala Gly 
                165                 170                 175     


Ala Val Gly Ala Gly Ala Tyr Arg Glu Val Glu Ala Glu Asp Pro Gly 
            180                 185                 190         


Arg Leu Ala Val Glu Ala Leu Val Arg Thr Arg Arg Cys Val Cys Val 
        195                 200                 205             


Ala Gln Arg Trp Gly Gly Lys Arg Glu Val Met Tyr Thr Ala Phe Lys 
    210                 215                 220                 


Ala Leu Gly Asp Ser Val Asp Tyr Val Gln Val Cys Asp Ser Asp Thr 
225                 230                 235                 240 


Arg Leu Asp Pro Met Ala Leu Leu Glu Leu Val Arg Val Leu Asp Glu 
                245                 250                 255     


Asp Pro Arg Val Gly Ala Val Gly Gly Asp Val Arg Ile Leu Asn Pro 
            260                 265                 270         


Leu Asp Ser Trp Val Ser Phe Leu Ser Ser Leu Arg Tyr Trp Val Ala 
        275                 280                 285             


Phe Asn Val Glu Arg Ala Cys Gln Ser Tyr Phe His Cys Val Ser Cys 
    290                 295                 300                 


Ile Ser Gly Pro Leu Gly Leu Tyr Arg Asn Asn Leu Leu Gln Gln Phe 
305                 310                 315                 320 


Leu Glu Ala Trp Tyr Asn Gln Lys Phe Leu Gly Thr His Cys Thr Phe 
                325                 330                 335     


Gly Asp Asp Arg His Leu Thr Asn Arg Met Leu Ser Met Gly Tyr Ala 
            340                 345                 350         


Thr Lys Tyr Thr Ser Arg Ser Arg Cys Tyr Ser Glu Thr Pro Ser Ser 
        355                 360                 365             


Phe Leu Arg Trp Leu Ser Gln Gln Thr Arg Trp Ser Lys Ser Tyr Phe 
    370                 375                 380                 


Arg Glu Trp Leu Tyr Asn Ala Leu Trp Trp His Arg His His Ala Trp 
385                 390                 395                 400 


Met Thr Tyr Glu Ala Val Val Ser Gly Leu Phe Pro Phe Phe Val Ala 
                405                 410                 415     


Ala Thr Val Leu Arg Leu Phe Tyr Ala Gly Arg Pro Trp Ala Leu Leu 
            420                 425                 430         


Trp Val Leu Leu Cys Val Gln Gly Val Ala Leu Ala Lys Ala Ala Phe 
        435                 440                 445             


Ala Ala Trp Leu Arg Gly Cys Leu Arg Met Val Leu Leu Ser Leu Tyr 
    450                 455                 460                 


Ala Pro Leu Tyr Met Cys Gly Leu Leu Pro Ala Lys Phe Leu Ala Leu 
465                 470                 475                 480 


Val Thr Met Asn Gln Ser Gly Trp Gly Thr Ser Gly Arg Arg Lys Leu 
                485                 490                 495     


Ala Ala Asn Tyr Val Pro Leu Leu Pro Leu Ala Leu Trp Ala Leu Leu 
            500                 505                 510         


Leu Leu Gly Gly Leu Val Arg Ser Val Ala His Glu Ala Arg Ala Asp 
        515                 520                 525             


Trp Ser Gly Pro Ser Arg Ala Ala Glu Ala Tyr His Leu Ala Ala Gly 
    530                 535                 540                 


Ala Gly Ala Tyr Val Gly Tyr Trp Val Ala Met Leu Thr Leu Tyr Trp 
545                 550                 555                 560 


Val Gly Val Arg Arg Leu Cys Arg Arg Arg Thr Gly Gly Tyr Arg Val 
                565                 570                 575     


Gln Val 
        


<210>  2401
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  2401

Met Asn Leu Pro Ser Thr Lys Val Ser Trp Ala Ala Val Thr Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Pro Pro Ala Leu Leu Ser Ser Gly Ala Ala 
            20                  25                  30          


Ala Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg 
        35                  40                  45              


Leu Tyr Glu Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu 
    50                  55                  60                  


Thr Leu Gly Lys Arg Arg Ser Gly Pro Pro Gly Leu Gln Gly Arg Leu 
65                  70                  75                  80  


Gln Arg Leu Leu Gln Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr 
                85                  90                  95      


Met Gly Arg Arg Ala Gly Ala Glu Pro Ala Pro Arg Pro Cys Leu Gly 
            100                 105                 110         


Arg Arg Cys Ser Ala Pro Ala Ala Ala Ser Val Ala Pro Gly Gly Gln 
        115                 120                 125             


Ser Gly Ile 
    130     


<210>  2402
<211>  425
<212>  PRT
<213>  Homo sapiens

<400>  2402

Met Glu Pro Ser Ala Thr Pro Gly Ala Gln Met Gly Val Pro Pro Gly 
1               5                   10                  15      


Ser Arg Glu Pro Ser Pro Val Pro Pro Asp Tyr Glu Asp Glu Phe Leu 
            20                  25                  30          


Arg Tyr Leu Trp Arg Asp Tyr Leu Tyr Pro Lys Gln Tyr Glu Trp Val 
        35                  40                  45              


Leu Ile Ala Ala Tyr Val Ala Val Phe Val Val Ala Leu Val Gly Asn 
    50                  55                  60                  


Thr Leu Val Cys Leu Ala Val Trp Arg Asn His His Met Arg Thr Val 
65                  70                  75                  80  


Thr Asn Tyr Phe Ile Val Asn Leu Ser Leu Ala Asp Val Leu Val Thr 
                85                  90                  95      


Ala Ile Cys Leu Pro Ala Ser Leu Leu Val Asp Ile Thr Glu Ser Trp 
            100                 105                 110         


Leu Phe Gly His Ala Leu Cys Lys Val Ile Pro Tyr Leu Gln Ala Val 
        115                 120                 125             


Ser Val Ser Val Ala Val Leu Thr Leu Ser Phe Ile Ala Leu Asp Arg 
    130                 135                 140                 


Trp Tyr Ala Ile Cys His Pro Leu Leu Phe Lys Ser Thr Ala Arg Arg 
145                 150                 155                 160 


Ala Arg Gly Ser Ile Leu Gly Ile Trp Ala Val Ser Leu Ala Ile Met 
                165                 170                 175     


Val Pro Gln Ala Ala Val Met Glu Cys Ser Ser Val Leu Pro Glu Leu 
            180                 185                 190         


Ala Asn Arg Thr Arg Leu Phe Ser Val Cys Asp Glu Arg Trp Ala Asp 
        195                 200                 205             


Asp Leu Tyr Pro Lys Ile Tyr His Ser Cys Phe Phe Ile Val Thr Tyr 
    210                 215                 220                 


Leu Ala Pro Leu Gly Leu Met Ala Met Ala Tyr Phe Gln Ile Phe Arg 
225                 230                 235                 240 


Lys Leu Trp Gly Arg Gln Ile Pro Gly Thr Thr Ser Ala Leu Val Arg 
                245                 250                 255     


Asn Trp Lys Arg Pro Ser Asp Gln Leu Gly Asp Leu Glu Gln Gly Leu 
            260                 265                 270         


Ser Gly Glu Pro Gln Pro Arg Ala Arg Ala Phe Leu Ala Glu Val Lys 
        275                 280                 285             


Gln Met Arg Ala Arg Arg Lys Thr Ala Lys Met Leu Met Val Val Leu 
    290                 295                 300                 


Leu Val Phe Ala Leu Cys Tyr Leu Pro Ile Ser Val Leu Asn Val Leu 
305                 310                 315                 320 


Lys Arg Val Phe Gly Met Phe Arg Gln Ala Ser Asp Arg Glu Ala Val 
                325                 330                 335     


Tyr Ala Cys Phe Thr Phe Ser His Trp Leu Val Tyr Ala Asn Ser Ala 
            340                 345                 350         


Ala Asn Pro Ile Ile Tyr Asn Phe Leu Ser Gly Lys Phe Arg Glu Gln 
        355                 360                 365             


Phe Lys Ala Ala Phe Ser Cys Cys Leu Pro Gly Leu Gly Pro Cys Gly 
    370                 375                 380                 


Ser Leu Lys Ala Pro Ser Pro Arg Ser Ser Ala Ser His Lys Ser Leu 
385                 390                 395                 400 


Ser Leu Gln Ser Arg Cys Ser Ile Ser Lys Ile Ser Glu His Val Val 
                405                 410                 415     


Leu Thr Ser Val Thr Thr Val Leu Pro 
            420                 425 


<210>  2403
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  2403

Met Ser Gly Thr Lys Leu Glu Asp Ser Pro Pro Cys Arg Asn Trp Ser 
1               5                   10                  15      


Ser Ala Ser Glu Leu Asn Glu Thr Gln Glu Pro Phe Leu Asn Pro Thr 
            20                  25                  30          


Asp Tyr Asp Asp Glu Glu Phe Leu Arg Tyr Leu Trp Arg Glu Tyr Leu 
        35                  40                  45              


His Pro Lys Glu Tyr Glu Trp Val Leu Ile Ala Gly Tyr Ile Ile Val 
    50                  55                  60                  


Phe Val Val Ala Leu Ile Gly Asn Val Leu Val Cys Val Ala Val Trp 
65                  70                  75                  80  


Lys Asn His His Met Arg Thr Val Thr Asn Tyr Phe Ile Val Asn Leu 
                85                  90                  95      


Ser Leu Ala Asp Val Leu Val Thr Ile Thr Cys Leu Pro Ala Thr Leu 
            100                 105                 110         


Val Val Asp Ile Thr Glu Thr Trp Phe Phe Gly Gln Ser Leu Cys Lys 
        115                 120                 125             


Val Ile Pro Tyr Leu Gln Thr Val Ser Val Ser Val Ser Val Leu Thr 
    130                 135                 140                 


Leu Ser Cys Ile Ala Leu Asp Arg Trp Tyr Ala Ile Cys His Pro Leu 
145                 150                 155                 160 


Met Phe Lys Ser Thr Ala Lys Arg Ala Arg Asn Ser Ile Val Ile Ile 
                165                 170                 175     


Trp Ile Val Ser Cys Ile Ile Met Ile Pro Gln Ala Ile Val Met Glu 
            180                 185                 190         


Cys Ser Thr Val Phe Pro Gly Leu Ala Asn Lys Thr Thr Leu Phe Thr 
        195                 200                 205             


Val Cys Asp Glu Arg Trp Gly Gly Glu Ile Tyr Pro Lys Met Tyr His 
    210                 215                 220                 


Ile Cys Phe Phe Leu Val Thr Tyr Met Ala Pro Leu Cys Leu Met Val 
225                 230                 235                 240 


Leu Ala Tyr Leu Gln Ile Phe Arg Lys Leu Trp Cys Arg Gln Ile Pro 
                245                 250                 255     


Gly Thr Ser Ser Val Val Gln Arg Lys Trp Lys Pro Leu Gln Pro Val 
            260                 265                 270         


Ser Gln Pro Arg Gly Pro Gly Gln Pro Thr Lys Ser Arg Met Ser Ala 
        275                 280                 285             


Val Ala Ala Glu Ile Lys Gln Ile Arg Ala Arg Arg Lys Thr Ala Arg 
    290                 295                 300                 


Met Leu Met Ile Val Leu Leu Val Phe Ala Ile Cys Tyr Leu Pro Ile 
305                 310                 315                 320 


Ser Ile Leu Asn Val Leu Lys Arg Val Phe Gly Met Phe Ala His Thr 
                325                 330                 335     


Glu Asp Arg Glu Thr Val Tyr Ala Trp Phe Thr Phe Ser His Trp Leu 
            340                 345                 350         


Val Tyr Ala Asn Ser Ala Ala Asn Pro Ile Ile Tyr Asn Phe Leu Ser 
        355                 360                 365             


Gly Lys Phe Arg Glu Glu Phe Lys Ala Ala Phe Ser Cys Cys Cys Leu 
    370                 375                 380                 


Gly Val His His Arg Gln Glu Asp Arg Leu Thr Arg Gly Arg Thr Ser 
385                 390                 395                 400 


Thr Glu Ser Arg Lys Ser Leu Thr Thr Gln Ile Ser Asn Phe Asp Asn 
                405                 410                 415     


Ile Ser Lys Leu Ser Glu Gln Val Val Leu Thr Ser Ile Ser Thr Leu 
            420                 425                 430         


Pro Ala Ala Asn Gly Ala Gly Pro Leu Gln Asn Trp 
        435                 440                 


<210>  2404
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  2404

Met Ala Tyr Ser Gln Gly Gly Gly Lys Lys Lys Val Cys Tyr Tyr Tyr 
1               5                   10                  15      


Asp Gly Asp Ile Gly Asn Tyr Tyr Tyr Gly Gln Gly His Pro Met Lys 
            20                  25                  30          


Pro His Arg Ile Arg Met Thr His Asn Leu Leu Leu Asn Tyr Gly Leu 
        35                  40                  45              


Tyr Arg Lys Met Glu Ile Tyr Arg Pro His Lys Ala Thr Ala Glu Glu 
    50                  55                  60                  


Met Thr Lys Tyr His Ser Asp Glu Tyr Ile Lys Phe Leu Arg Ser Ile 
65                  70                  75                  80  


Arg Pro Asp Asn Met Ser Glu Tyr Ser Lys Gln Met Gln Arg Phe Asn 
                85                  90                  95      


Val Gly Glu Asp Cys Pro Val Phe Asp Gly Leu Phe Glu Phe Cys Gln 
            100                 105                 110         


Leu Ser Thr Gly Gly Ser Val Ala Gly Ala Val Lys Leu Asn Arg Gln 
        115                 120                 125             


Gln Thr Asp Met Ala Val Asn Trp Ala Gly Gly Leu His His Ala Lys 
    130                 135                 140                 


Lys Ser Glu Ala Ser Gly Phe Cys Tyr Val Asn Asp Ile Val Leu Ala 
145                 150                 155                 160 


Ile Leu Glu Leu Leu Lys Tyr His Gln Arg Val Leu Tyr Ile Asp Ile 
                165                 170                 175     


Asp Ile His His Gly Asp Gly Val Glu Glu Ala Phe Tyr Thr Thr Asp 
            180                 185                 190         


Arg Val Met Thr Val Ser Phe His Lys Tyr Gly Glu Tyr Phe Pro Gly 
        195                 200                 205             


Thr Gly Asp Leu Arg Asp Ile Gly Ala Gly Lys Gly Lys Tyr Tyr Ala 
    210                 215                 220                 


Val Asn Phe Pro Met Arg Asp Gly Ile Asp Asp Glu Ser Tyr Gly Gln 
225                 230                 235                 240 


Ile Phe Lys Pro Ile Ile Ser Lys Val Met Glu Met Tyr Gln Pro Ser 
                245                 250                 255     


Ala Val Val Leu Gln Cys Gly Ala Asp Ser Leu Ser Gly Asp Arg Leu 
            260                 265                 270         


Gly Cys Phe Asn Leu Thr Val Lys Gly His Ala Lys Cys Val Glu Val 
        275                 280                 285             


Val Lys Thr Phe Asn Leu Pro Leu Leu Met Leu Gly Gly Gly Gly Tyr 
    290                 295                 300                 


Thr Ile Arg Asn Val Ala Arg Cys Trp Thr Tyr Glu Thr Ala Val Ala 
305                 310                 315                 320 


Leu Asp Cys Glu Ile Pro Asn Glu Leu Pro Tyr Asn Asp Tyr Phe Glu 
                325                 330                 335     


Tyr Phe Gly Pro Asp Phe Lys Leu His Ile Ser Pro Ser Asn Met Thr 
            340                 345                 350         


Asn Gln Asn Thr Pro Glu Tyr Met Glu Lys Ile Lys Gln Arg Leu Phe 
        355                 360                 365             


Glu Asn Leu Arg Met Leu Pro His Ala Pro Gly Val Gln Met Gln Ala 
    370                 375                 380                 


Ile Pro Glu Asp Ala Val His Glu Asp Ser Gly Asp Glu Asp Gly Glu 
385                 390                 395                 400 


Asp Pro Asp Lys Arg Ile Ser Ile Arg Ala Ser Asp Lys Arg Ile Ala 
                405                 410                 415     


Cys Asp Glu Glu Phe Ser Asp Ser Glu Asp Glu Gly Glu Gly Gly Arg 
            420                 425                 430         


Arg Asn Val Ala Asp His Lys Lys Gly Ala Lys Lys Ala Arg Ile Glu 
        435                 440                 445             


Glu Asp Lys Lys Glu Thr Glu Asp Lys Lys Thr Asp Val Lys Glu Glu 
    450                 455                 460                 


Asp Lys Ser Lys Asp Asn Ser Gly Glu Lys Thr Asp Thr Lys Gly Thr 
465                 470                 475                 480 


Lys Ser Glu Gln Leu Ser Asn Pro 
                485             


<210>  2405
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  2405

Met Gly Arg Trp Ala Trp Val Pro Ser Pro Trp Pro Pro Pro Gly Leu 
1               5                   10                  15      


Gly Pro Phe Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro Arg Gly 
            20                  25                  30          


Phe Gln Pro Gln Pro Gly Gly Asn Arg Thr Glu Ser Pro Glu Pro Asn 
        35                  40                  45              


Ala Thr Ala Thr Pro Ala Ile Pro Thr Ile Leu Val Thr Ser Val Thr 
    50                  55                  60                  


Ser Glu Thr Pro Ala Thr Ser Ala Pro Glu Ala Glu Gly Pro Gln Ser 
65                  70                  75                  80  


Gly Gly Leu Pro Pro Pro Pro Arg Ala Val Pro Ser Ser Ser Ser Pro 
                85                  90                  95      


Gln Ala Gln Ala Leu Thr Glu Asp Gly Arg Pro Cys Arg Phe Pro Phe 
            100                 105                 110         


Arg Tyr Gly Gly Arg Met Leu His Ala Cys Thr Ser Glu Gly Ser Ala 
        115                 120                 125             


His Arg Lys Trp Cys Ala Thr Thr His Asn Tyr Asp Arg Asp Arg Ala 
    130                 135                 140                 


Trp Gly Tyr Cys Val Glu Ala Thr Pro Pro Pro Gly Gly Pro Ala Ala 
145                 150                 155                 160 


Leu Asp Pro Cys Ala Ser Gly Pro Cys Leu Asn Gly Gly Ser Cys Ser 
                165                 170                 175     


Asn Thr Gln Asp Pro Gln Ser Tyr His Cys Ser Cys Pro Arg Ala Phe 
            180                 185                 190         


Thr Gly Lys Asp Cys Gly Thr Glu Lys Cys Phe Asp Glu Thr Arg Tyr 
        195                 200                 205             


Glu Tyr Leu Glu Gly Gly Asp Arg Trp Ala Arg Val Arg Gln Gly His 
    210                 215                 220                 


Val Glu Gln Cys Glu Cys Phe Gly Gly Arg Thr Trp Cys Glu Gly Thr 
225                 230                 235                 240 


Arg His Thr Ala Cys Leu Ser Ser Pro Cys Leu Asn Gly Gly Thr Cys 
                245                 250                 255     


His Leu Ile Val Ala Thr Gly Thr Thr Val Cys Ala Cys Pro Pro Gly 
            260                 265                 270         


Phe Ala Gly Arg Leu Cys Asn Ile Glu Pro Asp Glu Arg Cys Phe Leu 
        275                 280                 285             


Gly Asn Gly Thr Gly Tyr Arg Gly Val Ala Ser Thr Ser Ala Ser Gly 
    290                 295                 300                 


Leu Ser Cys Leu Ala Trp Asn Ser Asp Leu Leu Tyr Gln Glu Leu His 
305                 310                 315                 320 


Val Asp Ser Val Gly Ala Ala Ala Leu Leu Gly Leu Gly Pro His Ala 
                325                 330                 335     


Tyr Cys Arg Asn Pro Asp Asn Asp Glu Arg Pro Trp Cys Tyr Val Val 
            340                 345                 350         


Lys Asp Ser Ala Leu Ser Trp Glu Tyr Cys Arg Leu Glu Ala Cys Glu 
        355                 360                 365             


Ser Leu Thr Arg Val Gln Leu Ser Pro Asp Leu Leu Ala Thr Leu Pro 
    370                 375                 380                 


Glu Pro Ala Ser Pro Gly Arg Gln Ala Cys Gly Arg Arg His Lys Lys 
385                 390                 395                 400 


Arg Thr Phe Leu Arg Pro Arg Ile Ile Gly Gly Ser Ser Ser Leu Pro 
                405                 410                 415     


Gly Ser His Pro Trp Leu Ala Ala Ile Tyr Ile Gly Asp Ser Phe Cys 
            420                 425                 430         


Ala Gly Ser Leu Val His Thr Cys Trp Val Val Ser Ala Ala His Cys 
        435                 440                 445             


Phe Ser His Ser Pro Pro Arg Asp Ser Val Ser Val Val Leu Gly Gln 
    450                 455                 460                 


His Phe Phe Asn Arg Thr Thr Asp Val Thr Gln Thr Phe Gly Ile Glu 
465                 470                 475                 480 


Lys Tyr Ile Pro Tyr Thr Leu Tyr Ser Val Phe Asn Pro Ser Asp His 
                485                 490                 495     


Asp Leu Val Leu Ile Arg Leu Lys Lys Lys Gly Asp Arg Cys Ala Thr 
            500                 505                 510         


Arg Ser Gln Phe Val Gln Pro Ile Cys Leu Pro Glu Pro Gly Ser Thr 
        515                 520                 525             


Phe Pro Ala Gly His Lys Cys Gln Ile Ala Gly Trp Gly His Leu Asp 
    530                 535                 540                 


Glu Asn Val Ser Gly Tyr Ser Ser Ser Leu Arg Glu Ala Leu Val Pro 
545                 550                 555                 560 


Leu Val Ala Asp His Lys Cys Ser Ser Pro Glu Val Tyr Gly Ala Asp 
                565                 570                 575     


Ile Ser Pro Asn Met Leu Cys Ala Gly Tyr Phe Asp Cys Lys Ser Asp 
            580                 585                 590         


Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Ala Cys Glu Lys Asn Gly 
        595                 600                 605             


Val Ala Tyr Leu Tyr Gly Ile Ile Ser Trp Gly Asp Gly Cys Gly Arg 
    610                 615                 620                 


Leu His Lys Pro Gly Val Tyr Thr Arg Val Ala Asn Tyr Val Asp Trp 
625                 630                 635                 640 


Ile Asn Asp Arg Ile Arg Pro Pro Arg Arg Leu Val Ala Pro Ser 
                645                 650                 655 


<210>  2406
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  2406

Met Gly Glu Leu Met Ala Phe Leu Leu Pro Leu Ile Ile Val Leu Met 
1               5                   10                  15      


Val Lys His Ser Asp Ser Arg Thr His Ser Leu Arg Tyr Phe Arg Leu 
            20                  25                  30          


Gly Val Ser Asp Pro Ile His Gly Val Pro Glu Phe Ile Ser Val Gly 
        35                  40                  45              


Tyr Val Asp Ser His Pro Ile Thr Thr Tyr Asp Ser Val Thr Arg Gln 
    50                  55                  60                  


Lys Glu Pro Arg Ala Pro Trp Met Ala Glu Asn Leu Ala Pro Asp His 
65                  70                  75                  80  


Trp Glu Arg Tyr Thr Gln Leu Leu Arg Gly Trp Gln Gln Met Phe Lys 
                85                  90                  95      


Val Glu Leu Lys Arg Leu Gln Arg His Tyr Asn His Ser Gly Ser His 
            100                 105                 110         


Thr Tyr Gln Arg Met Ile Gly Cys Glu Leu Leu Glu Asp Gly Ser Thr 
        115                 120                 125             


Thr Gly Phe Leu Gln Tyr Ala Tyr Asp Gly Gln Asp Phe Leu Ile Phe 
    130                 135                 140                 


Asn Lys Asp Thr Leu Ser Trp Leu Ala Val Asp Asn Val Ala His Thr 
145                 150                 155                 160 


Ile Lys Gln Ala Trp Glu Ala Asn Gln His Glu Leu Leu Tyr Gln Lys 
                165                 170                 175     


Asn Trp Leu Glu Glu Glu Cys Ile Ala Trp Leu Lys Arg Phe Leu Glu 
            180                 185                 190         


Tyr Gly Lys Asp Thr Leu Gln Arg Thr Glu Pro Pro Leu Val Arg Val 
        195                 200                 205             


Asn Arg Lys Glu Thr Phe Pro Gly Val Thr Ala Leu Phe Cys Lys Ala 
    210                 215                 220                 


His Gly Phe Tyr Pro Pro Glu Ile Tyr Met Thr Trp Met Lys Asn Gly 
225                 230                 235                 240 


Glu Glu Ile Val Gln Glu Ile Asp Tyr Gly Asp Ile Leu Pro Ser Gly 
                245                 250                 255     


Asp Gly Thr Tyr Gln Ala Trp Ala Ser Ile Glu Leu Asp Pro Gln Ser 
            260                 265                 270         


Ser Asn Leu Tyr Ser Cys His Val Glu His Cys Gly Val His Met Val 
        275                 280                 285             


Leu Gln Val Pro Gln Glu Ser Glu Thr Ile Pro Leu Val Met Lys Ala 
    290                 295                 300                 


Val Ser Gly Ser Ile Val Leu Val Ile Val Leu Ala Gly Val Gly Val 
305                 310                 315                 320 


Leu Val Trp Arg Arg Arg Pro Arg Glu Gln Asn Gly Ala Ile Tyr Leu 
                325                 330                 335     


Pro Thr Pro Asp Arg 
            340     


<210>  2407
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  2407

Met Ala Arg Gly Asp Ala Pro Arg Asp Ser Tyr His Leu Val Gly Ile 
1               5                   10                  15      


Ser Phe Phe Ile Leu Gly Leu Gly Thr Leu Leu Pro Trp Asn Phe Phe 
            20                  25                  30          


Ile Thr Ala Ile Pro Tyr Phe Gln Ala Arg Leu Ala Gly Ala Gly Asn 
        35                  40                  45              


Ser Thr Ala Arg Ile Leu Ser Thr Asn His Thr Gly Pro Glu Asp Ala 
    50                  55                  60                  


Phe Asn Phe Asn Asn Trp Val Thr Leu Leu Ser Gln Leu Pro Leu Leu 
65                  70                  75                  80  


Leu Phe Thr Leu Leu Asn Ser Phe Leu Tyr Gln Cys Val Pro Glu Thr 
                85                  90                  95      


Val Arg Ile Leu Gly Ser Leu Leu Ala Ile Leu Leu Leu Phe Ala Leu 
            100                 105                 110         


Thr Ala Ala Leu Val Lys Val Asp Met Ser Pro Gly Pro Phe Phe Ser 
        115                 120                 125             


Ile Thr Met Ala Ser Val Cys Phe Ile Asn Ser Phe Ser Ala Val Leu 
    130                 135                 140                 


Gln Gly Ser Leu Phe Gly Gln Leu Gly Thr Met Pro Ser Thr Tyr Ser 
145                 150                 155                 160 


Thr Leu Phe Leu Ser Gly Gln Gly Leu Ala Gly Ile Phe Ala Ala Leu 
                165                 170                 175     


Ala Met Leu Leu Ser Met Ala Ser Gly Val Asp Ala Glu Thr Ser Ala 
            180                 185                 190         


Leu Gly Tyr Phe Ile Thr Pro Cys Val Gly Ile Leu Met Ser Ile Val 
        195                 200                 205             


Cys Tyr Leu Ser Leu Pro His Leu Lys Phe Ala Arg Tyr Tyr Leu Ala 
    210                 215                 220                 


Asn Lys Ser Ser Gln Ala Gln Ala Gln Glu Leu Glu Thr Lys Ala Glu 
225                 230                 235                 240 


Leu Leu Gln Ser Asp Glu Asn Gly Ile Pro Ser Ser Pro Gln Lys Val 
                245                 250                 255     


Ala Leu Thr Leu Asp Leu Asp Leu Glu Lys Glu Pro Glu Ser Glu Pro 
            260                 265                 270         


Asp Glu Pro Gln Lys Pro Gly Lys Pro Ser Val Phe Thr Val Phe Gln 
        275                 280                 285             


Lys Ile Trp Leu Thr Ala Leu Cys Leu Val Leu Val Phe Thr Val Thr 
    290                 295                 300                 


Leu Ser Val Phe Pro Ala Ile Thr Ala Met Val Thr Ser Ser Thr Ser 
305                 310                 315                 320 


Pro Gly Lys Trp Ser Gln Phe Phe Asn Pro Ile Cys Cys Phe Leu Leu 
                325                 330                 335     


Phe Asn Ile Met Asp Trp Leu Gly Arg Ser Leu Thr Ser Tyr Phe Leu 
            340                 345                 350         


Trp Pro Asp Glu Asp Ser Arg Leu Leu Pro Leu Leu Val Cys Leu Arg 
        355                 360                 365             


Phe Leu Phe Val Pro Leu Phe Met Leu Cys His Val Pro Gln Arg Ser 
    370                 375                 380                 


Arg Leu Pro Ile Leu Phe Pro Gln Asp Ala Tyr Phe Ile Thr Phe Met 
385                 390                 395                 400 


Leu Leu Phe Ala Val Ser Asn Gly Tyr Leu Val Ser Leu Thr Met Cys 
                405                 410                 415     


Leu Ala Pro Arg Gln Val Leu Pro His Glu Arg Glu Val Ala Gly Ala 
            420                 425                 430         


Leu Met Thr Phe Phe Leu Ala Leu Gly Leu Ser Cys Gly Ala Ser Leu 
        435                 440                 445             


Ser Phe Leu Phe Lys Ala Leu Leu 
    450                 455     


<210>  2408
<211>  1214
<212>  PRT
<213>  Homo sapiens

<400>  2408

Met Lys Cys Phe Phe Pro Val Leu Ser Cys Leu Ala Val Leu Gly Val 
1               5                   10                  15      


Val Ser Ala Gln Arg Gln Val Thr Val Gln Glu Gly Pro Leu Tyr Arg 
            20                  25                  30          


Thr Glu Gly Ser His Ile Thr Ile Trp Cys Asn Val Ser Gly Tyr Gln 
        35                  40                  45              


Gly Pro Ser Glu Gln Asn Phe Gln Trp Ser Ile Tyr Leu Pro Ser Ser 
    50                  55                  60                  


Pro Glu Arg Glu Val Gln Ile Val Ser Thr Met Asp Ser Ser Phe Pro 
65                  70                  75                  80  


Tyr Ala Ile Tyr Thr Gln Arg Val Arg Gly Gly Lys Ile Phe Ile Glu 
                85                  90                  95      


Arg Val Gln Gly Asn Ser Thr Leu Leu His Ile Thr Asp Leu Gln Ala 
            100                 105                 110         


Arg Asp Ala Gly Glu Tyr Glu Cys His Thr Pro Ser Thr Asp Lys Gln 
        115                 120                 125             


Tyr Phe Gly Ser Tyr Ser Ala Lys Met Asn Leu Val Val Ile Pro Asp 
    130                 135                 140                 


Ser Leu Gln Thr Thr Ala Met Pro Gln Thr Leu His Arg Val Glu Gln 
145                 150                 155                 160 


Asp Pro Leu Glu Leu Thr Cys Glu Val Ala Ser Glu Thr Ile Gln His 
                165                 170                 175     


Ser His Leu Ser Val Ala Trp Leu Arg Gln Lys Val Gly Glu Lys Pro 
            180                 185                 190         


Val Glu Val Ile Ser Leu Ser Arg Asp Phe Met Leu His Ser Ser Ser 
        195                 200                 205             


Glu Tyr Ala Gln Arg Gln Ser Leu Gly Glu Val Arg Leu Asp Lys Leu 
    210                 215                 220                 


Gly Arg Thr Thr Phe Arg Leu Thr Ile Phe His Leu Gln Pro Ser Asp 
225                 230                 235                 240 


Gln Gly Glu Phe Tyr Cys Glu Ala Ala Glu Trp Ile Gln Asp Pro Asp 
                245                 250                 255     


Gly Ser Trp Tyr Ala Met Thr Arg Lys Arg Ser Glu Gly Ala Val Val 
            260                 265                 270         


Asn Val Gln Pro Thr Asp Lys Glu Phe Thr Val Arg Leu Glu Thr Glu 
        275                 280                 285             


Lys Arg Leu His Thr Val Gly Glu Pro Val Glu Phe Arg Cys Ile Leu 
    290                 295                 300                 


Glu Ala Gln Asn Val Pro Asp Arg Tyr Phe Ala Val Ser Trp Ala Phe 
305                 310                 315                 320 


Asn Ser Ser Leu Ile Ala Thr Met Gly Pro Asn Ala Val Pro Val Leu 
                325                 330                 335     


Asn Ser Glu Phe Ala His Arg Glu Ala Arg Gly Gln Leu Lys Val Ala 
            340                 345                 350         


Lys Glu Ser Asp Ser Val Phe Val Leu Lys Ile Tyr His Leu Arg Gln 
        355                 360                 365             


Glu Asp Ser Gly Lys Tyr Asn Cys Arg Val Thr Glu Arg Glu Lys Thr 
    370                 375                 380                 


Val Thr Gly Glu Phe Ile Asp Lys Glu Ser Lys Arg Pro Lys Asn Ile 
385                 390                 395                 400 


Pro Ile Ile Val Leu Pro Leu Thr Asp Asn Trp Val Val Lys Val Pro 
                405                 410                 415     


Gln His His Gln Leu Leu Ser Gln Gly His Leu Glu Ser Ser Ile Ser 
            420                 425                 430         


Val Glu Val Ala Ser Asn Ala Ser Val Ile Leu Glu Gly Glu Asp Leu 
        435                 440                 445             


Arg Phe Ser Cys Ser Val Arg Thr Ala Gly Arg Pro Gln Gly Arg Phe 
    450                 455                 460                 


Ser Val Ile Trp Gln Leu Val Asp Arg Gln Asn Arg Arg Ser Asn Ile 
465                 470                 475                 480 


Met Trp Leu Asp Arg Asp Gly Thr Val Gln Pro Gly Ser Ser Tyr Trp 
                485                 490                 495     


Glu Arg Ser Ser Phe Gly Gly Val Gln Met Glu Gln Val Gln Pro Asn 
            500                 505                 510         


Ser Phe Ser Leu Gly Ile Phe Asn Ser Arg Lys Glu Asp Glu Gly Gln 
        515                 520                 525             


Tyr Glu Cys His Val Thr Glu Trp Val Arg Ala Val Asp Gly Glu Trp 
    530                 535                 540                 


Gln Ile Val Gly Glu Arg Arg Ala Ser Thr Pro Ile Ser Ile Thr Ala 
545                 550                 555                 560 


Leu Glu Met Gly Phe Ala Val Thr Ala Ile Ser Arg Thr Pro Gly Val 
                565                 570                 575     


Thr Tyr Ser Asp Ser Phe Asp Leu Gln Cys Ile Ile Lys Pro His Tyr 
            580                 585                 590         


Pro Ala Trp Val Pro Val Ser Val Thr Trp Arg Phe Gln Pro Val Gly 
        595                 600                 605             


Thr Val Glu Phe His Asp Leu Val Thr Phe Thr Arg Asp Gly Gly Val 
    610                 615                 620                 


Gln Trp Gly Asp Arg Ser Ser Ser Phe Arg Thr Arg Thr Ala Ile Glu 
625                 630                 635                 640 


Lys Ala Glu Ser Ser Asn Asn Val Arg Leu Ser Ile Ser Arg Ala Ser 
                645                 650                 655     


Asp Thr Glu Ala Gly Lys Tyr Gln Cys Val Ala Glu Leu Trp Arg Lys 
            660                 665                 670         


Asn Tyr Asn Asn Thr Trp Thr Arg Leu Ala Glu Arg Thr Ser Asn Leu 
        675                 680                 685             


Leu Glu Ile Arg Val Leu Gln Pro Val Thr Lys Leu Gln Val Ser Lys 
    690                 695                 700                 


Ser Lys Arg Thr Leu Thr Leu Val Glu Asn Lys Pro Ile Gln Leu Asn 
705                 710                 715                 720 


Cys Ser Val Lys Ser Gln Thr Ser Gln Asn Ser His Phe Ala Val Leu 
                725                 730                 735     


Trp Tyr Val His Lys Pro Ser Asp Ala Asp Gly Lys Leu Ile Leu Lys 
            740                 745                 750         


Thr Thr His Asn Ser Ala Phe Glu Tyr Gly Thr Tyr Ala Glu Glu Glu 
        755                 760                 765             


Gly Leu Arg Ala Arg Leu Gln Phe Glu Arg His Val Ser Gly Gly Leu 
    770                 775                 780                 


Phe Ser Leu Thr Val Gln Arg Ala Glu Val Ser Asp Ser Gly Ser Tyr 
785                 790                 795                 800 


Tyr Cys His Val Glu Glu Trp Leu Leu Ser Pro Asn Tyr Ala Trp Tyr 
                805                 810                 815     


Lys Leu Ala Glu Glu Val Ser Gly Arg Thr Glu Val Thr Val Lys Gln 
            820                 825                 830         


Pro Asp Ser Arg Leu Arg Leu Ser Gln Ala Gln Gly Asn Leu Ser Val 
        835                 840                 845             


Leu Glu Thr Arg Gln Val Gln Leu Glu Cys Val Val Leu Asn Arg Thr 
    850                 855                 860                 


Ser Ile Thr Ser Gln Leu Met Val Glu Trp Phe Val Trp Lys Pro Asn 
865                 870                 875                 880 


His Pro Glu Arg Glu Thr Val Ala Arg Leu Ser Arg Asp Ala Thr Phe 
                885                 890                 895     


His Tyr Gly Glu Gln Ala Ala Lys Asn Asn Leu Lys Gly Arg Leu His 
            900                 905                 910         


Leu Glu Ser Pro Ser Pro Gly Val Tyr Arg Leu Phe Ile Gln Asn Val 
        915                 920                 925             


Ala Val Gln Asp Ser Gly Thr Tyr Ser Cys His Val Glu Glu Trp Leu 
    930                 935                 940                 


Pro Ser Pro Ser Gly Met Trp Tyr Lys Arg Ala Glu Asp Thr Ala Gly 
945                 950                 955                 960 


Gln Thr Ala Leu Thr Val Met Arg Pro Asp Ala Ser Leu Gln Val Asp 
                965                 970                 975     


Thr Val Val Pro Asn Ala Thr Val Ser Glu Lys Ala Ala Phe Gln Leu 
            980                 985                 990         


Asp Cys Ser Ile Val Ser Arg Ser  Ser Gln Asp Ser Arg  Phe Ala Val 
        995                 1000                 1005             


Ala Trp  Tyr Ser Leu Arg Thr  Lys Ala Gly Gly Lys  Arg Ser Ser 
    1010                 1015                 1020             


Pro Gly  Leu Glu Glu Gln Glu  Glu Glu Arg Glu Glu  Glu Glu Glu 
    1025                 1030                 1035             


Glu Asp  Asp Asp Asp Asp Asp  Asp Pro Thr Glu Arg  Thr Ala Leu 
    1040                 1045                 1050             


Leu Ser  Val Gly Pro Asp Ala  Val Phe Gly Pro Glu  Gly Ser Pro 
    1055                 1060                 1065             


Trp Glu  Gly Arg Leu Arg Phe  Gln Arg Leu Ser Pro  Val Leu Tyr 
    1070                 1075                 1080             


Arg Leu  Thr Val Leu Gln Ala  Ser Pro Gln Asp Thr  Gly Asn Tyr 
    1085                 1090                 1095             


Ser Cys  His Val Glu Glu Trp  Leu Pro Ser Pro Gln  Lys Glu Trp 
    1100                 1105                 1110             


Tyr Arg  Leu Thr Glu Glu Glu  Ser Ala Pro Ile Gly  Ile Arg Val 
    1115                 1120                 1125             


Leu Asp  Thr Ser Pro Thr Leu  Gln Ser Ile Ile Cys  Ser Asn Asp 
    1130                 1135                 1140             


Ala Leu  Phe Tyr Phe Val Phe  Phe Tyr Pro Phe Pro  Ile Phe Gly 
    1145                 1150                 1155             


Ile Leu  Ile Ile Thr Ile Leu  Leu Val Arg Phe Lys  Ser Arg Asn 
    1160                 1165                 1170             


Ser Ser  Lys Asn Ser Asp Gly  Lys Asn Gly Val Pro  Leu Leu Trp 
    1175                 1180                 1185             


Ile Lys  Glu Pro His Leu Asn  Tyr Ser Pro Thr Cys  Leu Glu Pro 
    1190                 1195                 1200             


Pro Val  Leu Ser Ile His Pro  Gly Ala Ile Asp 
    1205                 1210                 


<210>  2409
<211>  882
<212>  PRT
<213>  Homo sapiens

<400>  2409

Met Pro Ala Leu Ala Cys Leu Arg Arg Leu Cys Arg His Val Ser Pro 
1               5                   10                  15      


Gln Ala Val Leu Phe Leu Leu Phe Ile Phe Cys Leu Phe Ser Val Phe 
            20                  25                  30          


Ile Ser Ala Tyr Tyr Leu Tyr Gly Trp Lys Arg Gly Leu Glu Pro Ser 
        35                  40                  45              


Ala Asp Ala Pro Glu Pro Asp Cys Gly Asp Pro Pro Pro Val Ala Pro 
    50                  55                  60                  


Ser Arg Leu Leu Pro Leu Lys Pro Val Gln Ala Ala Thr Pro Ser Arg 
65                  70                  75                  80  


Thr Asp Pro Leu Val Leu Val Phe Val Glu Ser Leu Tyr Ser Gln Leu 
                85                  90                  95      


Gly Gln Glu Val Val Ala Ile Leu Glu Ser Ser Arg Phe Lys Tyr Arg 
            100                 105                 110         


Thr Glu Ile Ala Pro Gly Lys Gly Asp Met Pro Thr Leu Thr Asp Lys 
        115                 120                 125             


Gly Arg Gly Arg Phe Ala Leu Ile Ile Tyr Glu Asn Ile Leu Lys Tyr 
    130                 135                 140                 


Val Asn Leu Asp Ala Trp Asn Arg Glu Leu Leu Asp Lys Tyr Cys Val 
145                 150                 155                 160 


Ala Tyr Gly Val Gly Ile Ile Gly Phe Phe Lys Ala Asn Glu Asn Ser 
                165                 170                 175     


Leu Leu Ser Ala Gln Leu Lys Gly Phe Pro Leu Phe Leu His Ser Asn 
            180                 185                 190         


Leu Gly Leu Lys Asp Cys Ser Ile Asn Pro Lys Ser Pro Leu Leu Tyr 
        195                 200                 205             


Val Thr Arg Pro Ser Glu Val Glu Lys Gly Val Leu Pro Gly Glu Asp 
    210                 215                 220                 


Trp Thr Val Phe Gln Ser Asn His Ser Thr Tyr Glu Pro Val Leu Leu 
225                 230                 235                 240 


Ala Lys Thr Arg Ser Ser Glu Ser Ile Pro His Leu Gly Ala Asp Ala 
                245                 250                 255     


Gly Leu His Ala Ala Leu His Ala Thr Val Val Gln Asp Leu Gly Leu 
            260                 265                 270         


His Asp Gly Ile Gln Arg Val Leu Phe Gly Asn Asn Leu Asn Phe Trp 
        275                 280                 285             


Leu His Lys Leu Val Phe Val Asp Ala Val Ala Phe Leu Thr Gly Lys 
    290                 295                 300                 


Arg Leu Ser Leu Pro Leu Asp Arg Tyr Ile Leu Val Asp Ile Asp Asp 
305                 310                 315                 320 


Ile Phe Val Gly Lys Glu Gly Thr Arg Met Lys Val Glu Asp Val Lys 
                325                 330                 335     


Ala Leu Phe Asp Thr Gln Asn Glu Leu Arg Ala His Ile Pro Asn Phe 
            340                 345                 350         


Thr Phe Asn Leu Gly Tyr Ser Gly Lys Phe Phe His Thr Gly Thr Asn 
        355                 360                 365             


Ala Glu Asp Ala Gly Asp Asp Leu Leu Leu Ser Tyr Val Lys Glu Phe 
    370                 375                 380                 


Trp Trp Phe Pro His Met Trp Ser His Met Gln Pro His Leu Phe His 
385                 390                 395                 400 


Asn Gln Ser Val Leu Ala Glu Gln Met Ala Leu Asn Lys Lys Phe Ala 
                405                 410                 415     


Val Glu His Gly Ile Pro Thr Asp Met Gly Tyr Ala Val Ala Pro His 
            420                 425                 430         


His Ser Gly Val Tyr Pro Val His Val Gln Leu Tyr Glu Ala Trp Lys 
        435                 440                 445             


Gln Val Trp Ser Ile Arg Val Thr Ser Thr Glu Glu Tyr Pro His Leu 
    450                 455                 460                 


Lys Pro Ala Arg Tyr Arg Arg Gly Phe Ile His Asn Gly Ile Met Val 
465                 470                 475                 480 


Leu Pro Arg Gln Thr Cys Gly Leu Phe Thr His Thr Ile Phe Tyr Asn 
                485                 490                 495     


Glu Tyr Pro Gly Gly Ser Ser Glu Leu Asp Lys Ile Ile Asn Gly Gly 
            500                 505                 510         


Glu Leu Phe Leu Thr Val Leu Leu Asn Pro Ile Ser Ile Phe Met Thr 
        515                 520                 525             


His Leu Ser Asn Tyr Gly Asn Asp Arg Leu Gly Leu Tyr Thr Phe Lys 
    530                 535                 540                 


His Leu Val Arg Phe Leu His Ser Trp Thr Asn Leu Arg Leu Gln Thr 
545                 550                 555                 560 


Leu Pro Pro Val Gln Leu Ala Gln Lys Tyr Phe Gln Ile Phe Ser Glu 
                565                 570                 575     


Glu Lys Asp Pro Leu Trp Gln Asp Pro Cys Glu Asp Lys Arg His Lys 
            580                 585                 590         


Asp Ile Trp Ser Lys Glu Lys Thr Cys Asp Arg Phe Pro Lys Leu Leu 
        595                 600                 605             


Ile Ile Gly Pro Gln Lys Thr Gly Thr Thr Ala Leu Tyr Leu Phe Leu 
    610                 615                 620                 


Gly Met His Pro Asp Leu Ser Ser Asn Tyr Pro Ser Ser Glu Thr Phe 
625                 630                 635                 640 


Glu Glu Ile Gln Phe Phe Asn Gly His Asn Tyr His Lys Gly Ile Asp 
                645                 650                 655     


Trp Tyr Met Glu Phe Phe Pro Ile Pro Ser Asn Thr Thr Ser Asp Phe 
            660                 665                 670         


Tyr Phe Glu Lys Ser Ala Asn Tyr Phe Asp Ser Glu Val Ala Pro Arg 
        675                 680                 685             


Arg Ala Ala Ala Leu Leu Pro Lys Ala Lys Val Leu Thr Ile Leu Ile 
    690                 695                 700                 


Asn Pro Ala Asp Arg Ala Tyr Ser Trp Tyr Gln His Gln Arg Ala His 
705                 710                 715                 720 


Asp Asp Pro Val Ala Leu Lys Tyr Thr Phe His Glu Val Ile Thr Ala 
                725                 730                 735     


Gly Ser Asp Ala Ser Ser Lys Leu Arg Ala Leu Gln Asn Arg Cys Leu 
            740                 745                 750         


Val Pro Gly Trp Tyr Ala Thr His Ile Glu Arg Trp Leu Ser Ala Tyr 
        755                 760                 765             


His Ala Asn Gln Ile Leu Val Leu Asp Gly Lys Leu Leu Arg Thr Glu 
    770                 775                 780                 


Pro Ala Lys Val Met Asp Met Val Gln Lys Phe Leu Gly Val Thr Asn 
785                 790                 795                 800 


Thr Ile Asp Tyr His Lys Thr Leu Ala Phe Asp Pro Lys Lys Gly Phe 
                805                 810                 815     


Trp Cys Gln Leu Leu Glu Gly Gly Lys Thr Lys Cys Leu Gly Lys Ser 
            820                 825                 830         


Lys Gly Arg Lys Tyr Pro Glu Met Asp Leu Asp Ser Arg Ala Phe Leu 
        835                 840                 845             


Lys Asp Tyr Tyr Arg Asp His Asn Ile Glu Leu Ser Lys Leu Leu Tyr 
    850                 855                 860                 


Lys Met Gly Gln Thr Leu Pro Thr Trp Leu Arg Glu Asp Leu Gln Asn 
865                 870                 875                 880 


Thr Arg 
        


<210>  2410
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  2410

Met Gly Ser Leu Phe Pro Leu Ser Leu Leu Phe Phe Leu Ala Ala Ala 
1               5                   10                  15      


Tyr Pro Gly Val Gly Ser Ala Leu Gly Arg Arg Thr Lys Arg Ala Gln 
            20                  25                  30          


Ser Pro Lys Gly Ser Pro Leu Ala Pro Ser Gly Thr Ser Val Pro Phe 
        35                  40                  45              


Trp Val Arg Met Ser Pro Glu Phe Val Ala Val Gln Pro Gly Lys Ser 
    50                  55                  60                  


Val Gln Leu Asn Cys Ser Asn Ser Cys Pro Gln Pro Gln Asn Ser Ser 
65                  70                  75                  80  


Leu Arg Thr Pro Leu Arg Gln Gly Lys Thr Leu Arg Gly Pro Gly Trp 
                85                  90                  95      


Val Ser Tyr Gln Leu Leu Asp Val Arg Ala Trp Ser Ser Leu Ala His 
            100                 105                 110         


Cys Leu Val Thr Cys Ala Gly Lys Thr Arg Trp Ala Thr Ser Arg Ile 
        115                 120                 125             


Thr Ala Tyr Lys Pro Pro His Ser Val Ile Leu Glu Pro Pro Val Leu 
    130                 135                 140                 


Lys Gly Arg Lys Tyr Thr Leu Arg Cys His Val Thr Gln Val Phe Pro 
145                 150                 155                 160 


Val Gly Tyr Leu Val Val Thr Leu Arg His Gly Ser Arg Val Ile Tyr 
                165                 170                 175     


Ser Glu Ser Leu Glu Arg Phe Thr Gly Leu Asp Leu Ala Asn Val Thr 
            180                 185                 190         


Leu Thr Tyr Glu Phe Ala Ala Gly Pro Arg Asp Phe Trp Gln Pro Val 
        195                 200                 205             


Ile Cys His Ala Arg Leu Asn Leu Asp Gly Leu Val Val Arg Asn Ser 
    210                 215                 220                 


Ser Ala Pro Ile Thr Leu Met Leu Ala Trp Ser Pro Ala Pro Thr Ala 
225                 230                 235                 240 


Leu Ala Ser Gly Ser Ile Ala Ala Leu Val Gly Ile Leu Leu Thr Val 
                245                 250                 255     


Gly Ala Ala Tyr Leu Cys Lys Cys Leu Ala Met Lys Ser Gln Ala 
            260                 265                 270     


<210>  2411
<211>  1336
<212>  PRT
<213>  Homo sapiens

<400>  2411

Met Thr Leu Asp Arg Pro Gly Glu Gly Ala Thr Met Leu Lys Thr Phe 
1               5                   10                  15      


Thr Val Leu Leu Phe Cys Ile Arg Met Ser Leu Gly Met Thr Ser Ile 
            20                  25                  30          


Val Met Asp Pro Gln Pro Glu Leu Trp Ile Glu Ser Asn Tyr Pro Gln 
        35                  40                  45              


Ala Pro Trp Glu Asn Ile Thr Leu Trp Cys Arg Ser Pro Ser Arg Ile 
    50                  55                  60                  


Ser Ser Lys Phe Leu Leu Leu Lys Asp Lys Thr Gln Met Thr Trp Ile 
65                  70                  75                  80  


Arg Pro Ser His Lys Thr Phe Gln Val Ser Phe Leu Ile Gly Ala Leu 
                85                  90                  95      


Thr Glu Ser Asn Ala Gly Leu Tyr Arg Cys Cys Tyr Trp Lys Glu Thr 
            100                 105                 110         


Gly Trp Ser Lys Pro Ser Lys Val Leu Glu Leu Glu Ala Pro Gly Gln 
        115                 120                 125             


Leu Pro Lys Pro Ile Phe Trp Ile Gln Ala Glu Thr Pro Ala Leu Pro 
    130                 135                 140                 


Gly Cys Asn Val Asn Ile Leu Cys His Gly Trp Leu Gln Asp Leu Val 
145                 150                 155                 160 


Phe Met Leu Phe Lys Glu Gly Tyr Ala Glu Pro Val Asp Tyr Gln Val 
                165                 170                 175     


Pro Thr Gly Thr Met Ala Ile Phe Ser Ile Asp Asn Leu Thr Pro Glu 
            180                 185                 190         


Asp Glu Gly Val Tyr Ile Cys Arg Thr His Ile Gln Met Leu Pro Thr 
        195                 200                 205             


Leu Trp Ser Glu Pro Ser Asn Pro Leu Lys Leu Val Val Ala Gly Leu 
    210                 215                 220                 


Tyr Pro Lys Pro Thr Leu Thr Ala His Pro Gly Pro Ile Met Ala Pro 
225                 230                 235                 240 


Gly Glu Ser Leu Asn Leu Arg Cys Gln Gly Pro Ile Tyr Gly Met Thr 
                245                 250                 255     


Phe Ala Leu Met Arg Val Glu Asp Leu Glu Lys Ser Phe Tyr His Lys 
            260                 265                 270         


Lys Thr Ile Lys Asn Glu Ala Asn Phe Phe Phe Gln Ser Leu Lys Ile 
        275                 280                 285             


Gln Asp Thr Gly His Tyr Leu Cys Phe Tyr Tyr Asp Ala Ser Tyr Arg 
    290                 295                 300                 


Gly Ser Leu Leu Ser Asp Val Leu Lys Ile Trp Val Thr Asp Thr Phe 
305                 310                 315                 320 


Pro Lys Thr Trp Leu Leu Ala Arg Pro Ser Ala Val Val Gln Met Gly 
                325                 330                 335     


Gln Asn Val Ser Leu Arg Cys Arg Gly Pro Val Asp Gly Val Gly Leu 
            340                 345                 350         


Ala Leu Tyr Lys Lys Gly Glu Asp Lys Pro Leu Gln Phe Leu Asp Ala 
        355                 360                 365             


Thr Ser Ile Asp Asp Asn Thr Ser Phe Phe Leu Asn Asn Val Thr Tyr 
    370                 375                 380                 


Ser Asp Thr Gly Ile Tyr Ser Cys His Tyr Leu Leu Thr Trp Lys Thr 
385                 390                 395                 400 


Ser Ile Arg Met Pro Ser His Asn Thr Val Glu Leu Met Val Val Asp 
                405                 410                 415     


Lys Pro Pro Lys Pro Ser Leu Ser Ala Trp Pro Ser Thr Val Phe Lys 
            420                 425                 430         


Leu Gly Lys Ala Ile Thr Leu Gln Cys Arg Val Ser His Pro Val Leu 
        435                 440                 445             


Glu Phe Ser Leu Glu Trp Glu Glu Arg Glu Thr Phe Gln Lys Phe Ser 
    450                 455                 460                 


Val Asn Gly Asp Phe Ile Ile Ser Asn Val Asp Gly Lys Gly Thr Gly 
465                 470                 475                 480 


Thr Tyr Ser Cys Ser Tyr Arg Val Glu Thr His Pro Asn Ile Trp Ser 
                485                 490                 495     


His Arg Ser Glu Pro Leu Lys Leu Met Gly Pro Ala Gly Tyr Leu Thr 
            500                 505                 510         


Trp Asn Tyr Val Leu Asn Glu Ala Ile Arg Leu Ser Leu Ile Met Gln 
        515                 520                 525             


Leu Val Ala Leu Leu Leu Val Val Leu Trp Ile Arg Trp Lys Cys Arg 
    530                 535                 540                 


Arg Leu Arg Ile Arg Glu Ala Trp Leu Leu Gly Thr Ala Gln Gly Val 
545                 550                 555                 560 


Thr Met Leu Phe Ile Val Thr Ala Leu Leu Cys Cys Gly Leu Cys Asn 
                565                 570                 575     


Gly Val Leu Ile Glu Glu Thr Glu Ile Val Met Pro Thr Pro Lys Pro 
            580                 585                 590         


Glu Leu Trp Ala Glu Thr Asn Phe Pro Leu Ala Pro Trp Lys Asn Leu 
        595                 600                 605             


Thr Leu Trp Cys Arg Ser Pro Ser Gly Ser Thr Lys Glu Phe Val Leu 
    610                 615                 620                 


Leu Lys Asp Gly Thr Gly Trp Ile Ala Thr Arg Pro Ala Ser Glu Gln 
625                 630                 635                 640 


Val Arg Ala Ala Phe Pro Leu Gly Ala Leu Thr Gln Ser His Thr Gly 
                645                 650                 655     


Ser Tyr His Cys His Ser Trp Glu Glu Met Ala Val Ser Glu Pro Ser 
            660                 665                 670         


Glu Ala Leu Glu Leu Val Gly Thr Asp Ile Leu Pro Lys Pro Val Ile 
        675                 680                 685             


Ser Ala Ser Pro Thr Ile Arg Gly Gln Glu Leu Gln Leu Arg Cys Lys 
    690                 695                 700                 


Gly Trp Leu Ala Gly Met Gly Phe Ala Leu Tyr Lys Glu Gly Glu Gln 
705                 710                 715                 720 


Glu Pro Val Gln Gln Leu Gly Ala Val Gly Arg Glu Ala Phe Phe Thr 
                725                 730                 735     


Ile Gln Arg Met Glu Asp Lys Asp Glu Gly Asn Tyr Ser Cys Arg Thr 
            740                 745                 750         


His Thr Glu Lys Arg Pro Phe Lys Trp Ser Glu Pro Ser Glu Pro Leu 
        755                 760                 765             


Glu Leu Val Ile Lys Glu Met Tyr Pro Lys Pro Phe Phe Lys Thr Trp 
    770                 775                 780                 


Ala Ser Pro Val Val Thr Pro Gly Ala Arg Val Thr Phe Asn Cys Ser 
785                 790                 795                 800 


Thr Pro His Gln His Met Ser Phe Ile Leu Tyr Lys Asp Gly Ser Glu 
                805                 810                 815     


Ile Ala Ser Ser Asp Arg Ser Trp Ala Ser Pro Gly Ala Ser Ala Ala 
            820                 825                 830         


His Phe Leu Ile Ile Ser Val Gly Ile Gly Asp Gly Gly Asn Tyr Ser 
        835                 840                 845             


Cys Arg Tyr Tyr Asp Phe Ser Ile Trp Ser Glu Pro Ser Asp Pro Val 
    850                 855                 860                 


Glu Leu Val Val Thr Glu Phe Tyr Pro Lys Pro Thr Leu Leu Ala Gln 
865                 870                 875                 880 


Pro Gly Pro Val Val Phe Pro Gly Lys Ser Val Ile Leu Arg Cys Gln 
                885                 890                 895     


Gly Thr Phe Gln Gly Met Arg Phe Ala Leu Leu Gln Glu Gly Ala His 
            900                 905                 910         


Val Pro Leu Gln Phe Arg Ser Val Ser Gly Asn Ser Ala Asp Phe Leu 
        915                 920                 925             


Leu His Thr Val Gly Ala Glu Asp Ser Gly Asn Tyr Ser Cys Ile Tyr 
    930                 935                 940                 


Tyr Glu Thr Thr Met Ser Asn Arg Gly Ser Tyr Leu Ser Met Pro Leu 
945                 950                 955                 960 


Met Ile Trp Val Thr Asp Thr Phe Pro Lys Pro Trp Leu Phe Ala Glu 
                965                 970                 975     


Pro Ser Ser Val Val Pro Met Gly Gln Asn Val Thr Leu Trp Cys Arg 
            980                 985                 990         


Gly Pro Val His Gly Val Gly Tyr  Ile Leu His Lys Glu  Gly Glu Ala 
        995                 1000                 1005             


Thr Ser  Met Gln Leu Trp Gly  Ser Thr Ser Asn Asp  Gly Ala Phe 
    1010                 1015                 1020             


Pro Ile  Thr Asn Ile Ser Gly  Thr Ser Met Gly Arg  Tyr Ser Cys 
    1025                 1030                 1035             


Cys Tyr  His Pro Asp Trp Thr  Ser Ser Ile Lys Ile  Gln Pro Ser 
    1040                 1045                 1050             


Asn Thr  Leu Glu Leu Leu Val  Thr Gly Leu Leu Pro  Lys Pro Ser 
    1055                 1060                 1065             


Leu Leu  Ala Gln Pro Gly Pro  Met Val Ala Pro Gly  Glu Asn Met 
    1070                 1075                 1080             


Thr Leu  Gln Cys Gln Gly Glu  Leu Pro Asp Ser Thr  Phe Val Leu 
    1085                 1090                 1095             


Leu Lys  Glu Gly Ala Gln Glu  Pro Leu Glu Gln Gln  Arg Pro Ser 
    1100                 1105                 1110             


Gly Tyr  Arg Ala Asp Phe Trp  Met Pro Ala Val Arg  Gly Glu Asp 
    1115                 1120                 1125             


Ser Gly  Ile Tyr Ser Cys Val  Tyr Tyr Leu Asp Ser  Thr Pro Phe 
    1130                 1135                 1140             


Ala Ala  Ser Asn His Ser Asp  Ser Leu Glu Ile Trp  Val Thr Asp 
    1145                 1150                 1155             


Lys Pro  Pro Lys Pro Ser Leu  Ser Ala Trp Pro Ser  Thr Met Phe 
    1160                 1165                 1170             


Lys Leu  Gly Lys Asp Ile Thr  Leu Gln Cys Arg Gly  Pro Leu Pro 
    1175                 1180                 1185             


Gly Val  Glu Phe Val Leu Glu  His Asp Gly Glu Glu  Ala Pro Gln 
    1190                 1195                 1200             


Gln Phe  Ser Glu Asp Gly Asp  Phe Val Ile Asn Asn  Val Glu Gly 
    1205                 1210                 1215             


Lys Gly  Ile Gly Asn Tyr Ser  Cys Ser Tyr Arg Leu  Gln Ala Tyr 
    1220                 1225                 1230             


Pro Asp  Ile Trp Ser Glu Pro  Ser Asp Pro Leu Glu  Leu Val Gly 
    1235                 1240                 1245             


Ala Ala  Gly Pro Val Ala Gln  Glu Cys Thr Val Gly  Asn Ile Val 
    1250                 1255                 1260             


Arg Ser  Ser Leu Ile Val Val  Val Val Val Ala Leu  Gly Val Val 
    1265                 1270                 1275             


Leu Ala  Ile Glu Trp Lys Lys  Trp Pro Arg Leu Arg  Thr Arg Gly 
    1280                 1285                 1290             


Ser Glu  Thr Asp Gly Arg Asp  Gln Thr Ile Ala Leu  Glu Glu Cys 
    1295                 1300                 1305             


Asn Gln  Glu Gly Glu Pro Gly  Thr Pro Ala Asn Ser  Pro Ser Ser 
    1310                 1315                 1320             


Thr Ser  Gln Arg Ile Ser Val  Glu Leu Pro Val Pro  Ile 
    1325                 1330                 1335     


<210>  2412
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  2412

Met Glu Asp Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys 
1               5                   10                  15      


Gly Glu Asp Leu Ser Asn Tyr Ser Tyr Ser Ser Thr Leu Pro Pro Phe 
            20                  25                  30          


Leu Leu Asp Ala Ala Pro Cys Glu Pro Glu Ser Leu Glu Ile Asn Lys 
        35                  40                  45              


Tyr Phe Val Val Ile Ile Tyr Ala Leu Val Phe Leu Leu Ser Leu Leu 
    50                  55                  60                  


Gly Asn Ser Leu Val Met Leu Val Ile Leu Tyr Ser Arg Val Gly Arg 
65                  70                  75                  80  


Ser Val Thr Asp Val Tyr Leu Leu Asn Leu Ala Leu Ala Asp Leu Leu 
                85                  90                  95      


Phe Ala Leu Thr Leu Pro Ile Trp Ala Ala Ser Lys Val Asn Gly Trp 
            100                 105                 110         


Ile Phe Gly Thr Phe Leu Cys Lys Val Val Ser Leu Leu Lys Glu Val 
        115                 120                 125             


Asn Phe Tyr Ser Gly Ile Leu Leu Leu Ala Cys Ile Ser Val Asp Arg 
    130                 135                 140                 


Tyr Leu Ala Ile Val His Ala Thr Arg Thr Leu Thr Gln Lys Arg Tyr 
145                 150                 155                 160 


Leu Val Lys Phe Ile Cys Leu Ser Ile Trp Gly Leu Ser Leu Leu Leu 
                165                 170                 175     


Ala Leu Pro Val Leu Leu Phe Arg Arg Thr Val Tyr Ser Ser Asn Val 
            180                 185                 190         


Ser Pro Ala Cys Tyr Glu Asp Met Gly Asn Asn Thr Ala Asn Trp Arg 
        195                 200                 205             


Met Leu Leu Arg Ile Leu Pro Gln Ser Phe Gly Phe Ile Val Pro Leu 
    210                 215                 220                 


Leu Ile Met Leu Phe Cys Tyr Gly Phe Thr Leu Arg Thr Leu Phe Lys 
225                 230                 235                 240 


Ala His Met Gly Gln Lys His Arg Ala Met Arg Val Ile Phe Ala Val 
                245                 250                 255     


Val Leu Ile Phe Leu Leu Cys Trp Leu Pro Tyr Asn Leu Val Leu Leu 
            260                 265                 270         


Ala Asp Thr Leu Met Arg Thr Gln Val Ile Gln Glu Thr Cys Glu Arg 
        275                 280                 285             


Arg Asn His Ile Asp Arg Ala Leu Asp Ala Thr Glu Ile Leu Gly Ile 
    290                 295                 300                 


Leu His Ser Cys Leu Asn Pro Leu Ile Tyr Ala Phe Ile Gly Gln Lys 
305                 310                 315                 320 


Phe Arg His Gly Leu Leu Lys Ile Leu Ala Ile His Gly Leu Ile Ser 
                325                 330                 335     


Lys Asp Ser Leu Pro Lys Asp Ser Arg Pro Ser Phe Val Gly Ser Ser 
            340                 345                 350         


Ser Gly His Thr Ser Thr Thr Leu 
        355                 360 


<210>  2413
<211>  578
<212>  PRT
<213>  Homo sapiens

<400>  2413

Met Leu Pro Cys Leu Val Val Leu Leu Ala Ala Leu Leu Ser Leu Arg 
1               5                   10                  15      


Leu Gly Ser Asp Ala His Gly Thr Glu Leu Pro Ser Pro Pro Ser Val 
            20                  25                  30          


Trp Phe Glu Ala Glu Phe Phe His His Ile Leu His Trp Thr Pro Ile 
        35                  40                  45              


Pro Asn Gln Ser Glu Ser Thr Cys Tyr Glu Val Ala Leu Leu Arg Tyr 
    50                  55                  60                  


Gly Ile Glu Ser Trp Asn Ser Ile Ser Asn Cys Ser Gln Thr Leu Ser 
65                  70                  75                  80  


Tyr Asp Leu Thr Ala Val Thr Leu Asp Leu Tyr His Ser Asn Gly Tyr 
                85                  90                  95      


Arg Ala Arg Val Arg Ala Val Asp Gly Ser Arg His Ser Asn Trp Thr 
            100                 105                 110         


Val Thr Asn Thr Arg Phe Ser Val Asp Glu Val Thr Leu Thr Val Gly 
        115                 120                 125             


Ser Val Asn Leu Glu Ile His Asn Gly Phe Ile Leu Gly Lys Ile Gln 
    130                 135                 140                 


Leu Pro Arg Pro Lys Met Ala Pro Ala Asn Asp Thr Tyr Glu Ser Ile 
145                 150                 155                 160 


Phe Ser His Phe Arg Glu Tyr Glu Ile Ala Ile Arg Lys Val Pro Gly 
                165                 170                 175     


Asn Phe Thr Phe Thr His Lys Lys Val Lys His Glu Asn Phe Ser Leu 
            180                 185                 190         


Leu Thr Ser Gly Glu Val Gly Glu Phe Cys Val Gln Val Lys Pro Ser 
        195                 200                 205             


Val Ala Ser Arg Ser Asn Lys Gly Met Trp Ser Lys Glu Glu Cys Ile 
    210                 215                 220                 


Ser Leu Thr Arg Gln Tyr Phe Thr Val Thr Asn Val Ile Ile Phe Phe 
225                 230                 235                 240 


Ala Phe Val Leu Leu Leu Ser Gly Ala Leu Ala Tyr Cys Leu Ala Leu 
                245                 250                 255     


Gln Leu Tyr Val Arg Arg Arg Lys Lys Leu Pro Ser Val Leu Leu Phe 
            260                 265                 270         


Lys Lys Pro Ser Pro Phe Ile Phe Ile Ser Gln Arg Pro Ser Pro Glu 
        275                 280                 285             


Thr Gln Asp Thr Ile His Pro Leu Asp Glu Glu Ala Phe Leu Lys Val 
    290                 295                 300                 


Ser Pro Glu Leu Lys Asn Leu Asp Leu His Gly Ser Thr Asp Ser Gly 
305                 310                 315                 320 


Phe Gly Ser Thr Lys Pro Ser Leu Gln Thr Glu Glu Pro Gln Phe Leu 
                325                 330                 335     


Leu Pro Asp Pro His Pro Gln Ala Asp Arg Thr Leu Gly Asn Arg Glu 
            340                 345                 350         


Pro Pro Val Leu Gly Asp Ser Cys Ser Ser Gly Ser Ser Asn Ser Thr 
        355                 360                 365             


Asp Ser Gly Ile Cys Leu Gln Glu Pro Ser Leu Ser Pro Ser Thr Gly 
    370                 375                 380                 


Pro Thr Trp Glu Gln Gln Val Gly Ser Asn Ser Arg Gly Gln Asp Asp 
385                 390                 395                 400 


Ser Gly Ile Asp Leu Val Gln Asn Ser Glu Gly Arg Ala Gly Asp Thr 
                405                 410                 415     


Gln Gly Gly Ser Ala Leu Gly His His Ser Pro Pro Glu Pro Glu Val 
            420                 425                 430         


Pro Gly Glu Glu Asp Pro Ala Ala Val Ala Phe Gln Gly Tyr Leu Arg 
        435                 440                 445             


Gln Thr Arg Cys Ala Glu Glu Lys Ala Thr Lys Thr Gly Cys Leu Glu 
    450                 455                 460                 


Glu Glu Ser Pro Leu Thr Asp Gly Leu Gly Pro Lys Phe Gly Arg Cys 
465                 470                 475                 480 


Leu Val Asp Glu Ala Gly Leu His Pro Pro Ala Leu Ala Lys Gly Tyr 
                485                 490                 495     


Leu Lys Gln Asp Pro Leu Glu Met Thr Leu Ala Ser Ser Gly Ala Pro 
            500                 505                 510         


Thr Gly Gln Trp Asn Gln Pro Thr Glu Glu Trp Ser Leu Leu Ala Leu 
        515                 520                 525             


Ser Ser Cys Ser Asp Leu Gly Ile Ser Asp Trp Ser Phe Ala His Asp 
    530                 535                 540                 


Leu Ala Pro Leu Gly Cys Val Ala Ala Pro Gly Gly Leu Leu Gly Ser 
545                 550                 555                 560 


Phe Asn Ser Asp Leu Val Thr Leu Pro Leu Ile Ser Ser Leu Gln Ser 
                565                 570                 575     


Ser Glu 
        


<210>  2414
<211>  862
<212>  PRT
<213>  Homo sapiens

<400>  2414

Met Ala His Thr Phe Arg Gly Cys Ser Leu Ala Phe Met Phe Ile Ile 
1               5                   10                  15      


Thr Trp Leu Leu Ile Lys Ala Lys Ile Asp Ala Cys Lys Arg Gly Asp 
            20                  25                  30          


Val Thr Val Lys Pro Ser His Val Ile Leu Leu Gly Ser Thr Val Asn 
        35                  40                  45              


Ile Thr Cys Ser Leu Lys Pro Arg Gln Gly Cys Phe His Tyr Ser Arg 
    50                  55                  60                  


Arg Asn Lys Leu Ile Leu Tyr Lys Phe Asp Arg Arg Ile Asn Phe His 
65                  70                  75                  80  


His Gly His Ser Leu Asn Ser Gln Val Thr Gly Leu Pro Leu Gly Thr 
                85                  90                  95      


Thr Leu Phe Val Cys Lys Leu Ala Cys Ile Asn Ser Asp Glu Ile Gln 
            100                 105                 110         


Ile Cys Gly Ala Glu Ile Phe Val Gly Val Ala Pro Glu Gln Pro Gln 
        115                 120                 125             


Asn Leu Ser Cys Ile Gln Lys Gly Glu Gln Gly Thr Val Ala Cys Thr 
    130                 135                 140                 


Trp Glu Arg Gly Arg Asp Thr His Leu Tyr Thr Glu Tyr Thr Leu Gln 
145                 150                 155                 160 


Leu Ser Gly Pro Lys Asn Leu Thr Trp Gln Lys Gln Cys Lys Asp Ile 
                165                 170                 175     


Tyr Cys Asp Tyr Leu Asp Phe Gly Ile Asn Leu Thr Pro Glu Ser Pro 
            180                 185                 190         


Glu Ser Asn Phe Thr Ala Lys Val Thr Ala Val Asn Ser Leu Gly Ser 
        195                 200                 205             


Ser Ser Ser Leu Pro Ser Thr Phe Thr Phe Leu Asp Ile Val Arg Pro 
    210                 215                 220                 


Leu Pro Pro Trp Asp Ile Arg Ile Lys Phe Gln Lys Ala Ser Val Ser 
225                 230                 235                 240 


Arg Cys Thr Leu Tyr Trp Arg Asp Glu Gly Leu Val Leu Leu Asn Arg 
                245                 250                 255     


Leu Arg Tyr Arg Pro Ser Asn Ser Arg Leu Trp Asn Met Val Asn Val 
            260                 265                 270         


Thr Lys Ala Lys Gly Arg His Asp Leu Leu Asp Leu Lys Pro Phe Thr 
        275                 280                 285             


Glu Tyr Glu Phe Gln Ile Ser Ser Lys Leu His Leu Tyr Lys Gly Ser 
    290                 295                 300                 


Trp Ser Asp Trp Ser Glu Ser Leu Arg Ala Gln Thr Pro Glu Glu Glu 
305                 310                 315                 320 


Pro Thr Gly Met Leu Asp Val Trp Tyr Met Lys Arg His Ile Asp Tyr 
                325                 330                 335     


Ser Arg Gln Gln Ile Ser Leu Phe Trp Lys Asn Leu Ser Val Ser Glu 
            340                 345                 350         


Ala Arg Gly Lys Ile Leu His Tyr Gln Val Thr Leu Gln Glu Leu Thr 
        355                 360                 365             


Gly Gly Lys Ala Met Thr Gln Asn Ile Thr Gly His Thr Ser Trp Thr 
    370                 375                 380                 


Thr Val Ile Pro Arg Thr Gly Asn Trp Ala Val Ala Val Ser Ala Ala 
385                 390                 395                 400 


Asn Ser Lys Gly Ser Ser Leu Pro Thr Arg Ile Asn Ile Met Asn Leu 
                405                 410                 415     


Cys Glu Ala Gly Leu Leu Ala Pro Arg Gln Val Ser Ala Asn Ser Glu 
            420                 425                 430         


Gly Met Asp Asn Ile Leu Val Thr Trp Gln Pro Pro Arg Lys Asp Pro 
        435                 440                 445             


Ser Ala Val Gln Glu Tyr Val Val Glu Trp Arg Glu Leu His Pro Gly 
    450                 455                 460                 


Gly Asp Thr Gln Val Pro Leu Asn Trp Leu Arg Ser Arg Pro Tyr Asn 
465                 470                 475                 480 


Val Ser Ala Leu Ile Ser Glu Asn Ile Lys Ser Tyr Ile Cys Tyr Glu 
                485                 490                 495     


Ile Arg Val Tyr Ala Leu Ser Gly Asp Gln Gly Gly Cys Ser Ser Ile 
            500                 505                 510         


Leu Gly Asn Ser Lys His Lys Ala Pro Leu Ser Gly Pro His Ile Asn 
        515                 520                 525             


Ala Ile Thr Glu Glu Lys Gly Ser Ile Leu Ile Ser Trp Asn Ser Ile 
    530                 535                 540                 


Pro Val Gln Glu Gln Met Gly Cys Leu Leu His Tyr Arg Ile Tyr Trp 
545                 550                 555                 560 


Lys Glu Arg Asp Ser Asn Ser Gln Pro Gln Leu Cys Glu Ile Pro Tyr 
                565                 570                 575     


Arg Val Ser Gln Asn Ser His Pro Ile Asn Ser Leu Gln Pro Arg Val 
            580                 585                 590         


Thr Tyr Val Leu Trp Met Thr Ala Leu Thr Ala Ala Gly Glu Ser Ser 
        595                 600                 605             


His Gly Asn Glu Arg Glu Phe Cys Leu Gln Gly Lys Ala Asn Trp Met 
    610                 615                 620                 


Ala Phe Val Ala Pro Ser Ile Cys Ile Ala Ile Ile Met Val Gly Ile 
625                 630                 635                 640 


Phe Ser Thr His Tyr Phe Gln Gln Lys Val Phe Val Leu Leu Ala Ala 
                645                 650                 655     


Leu Arg Pro Gln Trp Cys Ser Arg Glu Ile Pro Asp Pro Ala Asn Ser 
            660                 665                 670         


Thr Cys Ala Lys Lys Tyr Pro Ile Ala Glu Glu Lys Thr Gln Leu Pro 
        675                 680                 685             


Leu Asp Arg Leu Leu Ile Asp Trp Pro Thr Pro Glu Asp Pro Glu Pro 
    690                 695                 700                 


Leu Val Ile Ser Glu Val Leu His Gln Val Thr Pro Val Phe Arg His 
705                 710                 715                 720 


Pro Pro Cys Ser Asn Trp Pro Gln Arg Glu Lys Gly Ile Gln Gly His 
                725                 730                 735     


Gln Ala Ser Glu Lys Asp Met Met His Ser Ala Ser Ser Pro Pro Pro 
            740                 745                 750         


Pro Arg Ala Leu Gln Ala Glu Ser Arg Gln Leu Val Asp Leu Tyr Lys 
        755                 760                 765             


Val Leu Glu Ser Arg Gly Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys 
    770                 775                 780                 


Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr 
785                 790                 795                 800 


Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala 
                805                 810                 815     


Asp Ser Leu Glu Glu Leu Glu Pro Gln His Ile Ser Leu Ser Val Phe 
            820                 825                 830         


Pro Ser Ser Ser Leu His Pro Leu Thr Phe Ser Cys Gly Asp Lys Leu 
        835                 840                 845             


Thr Leu Asp Gln Leu Lys Met Arg Cys Asp Ser Leu Met Leu 
    850                 855                 860         


<210>  2415
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  2415

Met Glu Trp Pro Ala Arg Leu Cys Gly Leu Trp Ala Leu Leu Leu Cys 
1               5                   10                  15      


Ala Gly Gly Gly Gly Gly Gly Gly Gly Ala Ala Pro Thr Glu Thr Gln 
            20                  25                  30          


Pro Pro Val Thr Asn Leu Ser Val Ser Val Glu Asn Leu Cys Thr Val 
        35                  40                  45              


Ile Trp Thr Trp Asn Pro Pro Glu Gly Ala Ser Ser Asn Cys Ser Leu 
    50                  55                  60                  


Trp Tyr Phe Ser His Phe Gly Asp Lys Gln Asp Lys Lys Ile Ala Pro 
65                  70                  75                  80  


Glu Thr Arg Arg Ser Ile Glu Val Pro Leu Asn Glu Arg Ile Cys Leu 
                85                  90                  95      


Gln Val Gly Ser Gln Cys Ser Thr Asn Glu Ser Glu Lys Pro Ser Ile 
            100                 105                 110         


Leu Val Glu Lys Cys Ile Ser Pro Pro Glu Gly Asp Pro Glu Ser Ala 
        115                 120                 125             


Val Thr Glu Leu Gln Cys Ile Trp His Asn Leu Ser Tyr Met Lys Cys 
    130                 135                 140                 


Ser Trp Leu Pro Gly Arg Asn Thr Ser Pro Asp Thr Asn Tyr Thr Leu 
145                 150                 155                 160 


Tyr Tyr Trp His Arg Ser Leu Glu Lys Ile His Gln Cys Glu Asn Ile 
                165                 170                 175     


Phe Arg Glu Gly Gln Tyr Phe Gly Cys Ser Phe Asp Leu Thr Lys Val 
            180                 185                 190         


Lys Asp Ser Ser Phe Glu Gln His Ser Val Gln Ile Met Val Lys Asp 
        195                 200                 205             


Asn Ala Gly Lys Ile Lys Pro Ser Phe Asn Ile Val Pro Leu Thr Ser 
    210                 215                 220                 


Arg Val Lys Pro Asp Pro Pro His Ile Lys Asn Leu Ser Phe His Asn 
225                 230                 235                 240 


Asp Asp Leu Tyr Val Gln Trp Glu Asn Pro Gln Asn Phe Ile Ser Arg 
                245                 250                 255     


Cys Leu Phe Tyr Glu Val Glu Val Asn Asn Ser Gln Thr Glu Thr His 
            260                 265                 270         


Asn Val Phe Tyr Val Gln Glu Ala Lys Cys Glu Asn Pro Glu Phe Glu 
        275                 280                 285             


Arg Asn Val Glu Asn Thr Ser Cys Phe Met Val Pro Gly Val Leu Pro 
    290                 295                 300                 


Asp Thr Leu Asn Thr Val Arg Ile Arg Val Lys Thr Asn Lys Leu Cys 
305                 310                 315                 320 


Tyr Glu Asp Asp Lys Leu Trp Ser Asn Trp Ser Gln Glu Met Ser Ile 
                325                 330                 335     


Gly Lys Lys Arg Asn Ser Thr Leu Tyr Ile Thr Met Leu Leu Ile Val 
            340                 345                 350         


Pro Val Ile Val Ala Gly Ala Ile Ile Val Leu Leu Leu Tyr Leu Lys 
        355                 360                 365             


Arg Leu Lys Ile Ile Ile Phe Pro Pro Ile Pro Asp Pro Gly Lys Ile 
    370                 375                 380                 


Phe Lys Glu Met Phe Gly Asp Gln Asn Asp Asp Thr Leu His Trp Lys 
385                 390                 395                 400 


Lys Tyr Asp Ile Tyr Glu Lys Gln Thr Lys Glu Glu Thr Asp Ser Val 
                405                 410                 415     


Val Leu Ile Glu Asn Leu Lys Lys Ala Ser Gln 
            420                 425         


<210>  2416
<211>  954
<212>  PRT
<213>  Homo sapiens

<400>  2416

Met Thr Ala Arg Glu His Ser Pro Arg His Gly Ala Arg Ala Arg Ala 
1               5                   10                  15      


Met Gln Arg Ala Ser Thr Ile Asp Val Ala Ala Asp Met Leu Gly Leu 
            20                  25                  30          


Ser Leu Ala Gly Asn Ile Gln Asp Pro Asp Glu Pro Ile Leu Glu Phe 
        35                  40                  45              


Ser Leu Ala Cys Ser Glu Leu His Thr Pro Ser Leu Asp Arg Lys Pro 
    50                  55                  60                  


Asn Ser Phe Val Ala Val Ser Val Thr Thr Pro Pro Gln Ala Phe Trp 
65                  70                  75                  80  


Thr Lys His Ala Gln Thr Glu Ile Ile Glu Gly Thr Asn Asn Pro Ile 
                85                  90                  95      


Phe Leu Ser Ser Ile Ala Phe Phe Gln Asp Ser Leu Ile Asn Gln Met 
            100                 105                 110         


Thr Gln Val Lys Leu Ser Val Tyr Asp Val Lys Asp Arg Ser Gln Gly 
        115                 120                 125             


Thr Met Tyr Leu Leu Gly Ser Gly Thr Phe Ile Val Lys Asp Leu Leu 
    130                 135                 140                 


Gln Asp Arg His His Arg Leu His Leu Thr Leu Arg Ser Ala Glu Ser 
145                 150                 155                 160 


Asp Arg Val Gly Asn Ile Thr Val Ile Gly Trp Gln Met Glu Glu Lys 
                165                 170                 175     


Ser Asp Gln Arg Pro Pro Val Thr Arg Ser Val Asp Thr Val Asn Gly 
            180                 185                 190         


Arg Met Val Leu Pro Val Asp Glu Ser Leu Thr Glu Ala Leu Gly Ile 
        195                 200                 205             


Arg Ser Lys Tyr Ala Ser Leu Arg Lys Asp Thr Leu Leu Lys Ser Val 
    210                 215                 220                 


Phe Gly Gly Ala Ile Cys Arg Met Tyr Arg Phe Pro Thr Thr Asp Gly 
225                 230                 235                 240 


Asn His Leu Arg Ile Leu Glu Gln Met Ala Glu Ser Val Leu Ser Leu 
                245                 250                 255     


His Val Pro Arg Gln Phe Val Lys Leu Leu Leu Glu Glu Asp Ala Ala 
            260                 265                 270         


Arg Val Cys Glu Leu Glu Glu Leu Gly Glu Leu Ser Pro Cys Trp Glu 
        275                 280                 285             


Ser Leu Arg Arg Gln Ile Val Thr Gln Tyr Gln Thr Ile Ile Leu Thr 
    290                 295                 300                 


Tyr Gln Glu Asn Leu Thr Asp Leu His Gln Tyr Arg Gly Pro Ser Phe 
305                 310                 315                 320 


Lys Ala Ser Ser Leu Lys Ala Asp Lys Lys Leu Glu Phe Val Pro Thr 
                325                 330                 335     


Asn Leu His Ile Gln Arg Met Arg Val Gln Asp Asp Gly Gly Ser Asp 
            340                 345                 350         


Gln Asn Tyr Asp Ile Val Thr Ile Gly Ala Pro Ala Ala His Cys Gln 
        355                 360                 365             


Gly Phe Lys Ser Gly Gly Leu Arg Lys Lys Leu His Lys Phe Glu Glu 
    370                 375                 380                 


Thr Lys Lys His Phe Glu Glu Cys Cys Thr Ser Ser Gly Cys Gln Ser 
385                 390                 395                 400 


Ile Ile Tyr Ile Pro Gln Asp Val Val Arg Ala Lys Glu Ile Ile Ala 
                405                 410                 415     


Gln Ile Asn Thr Leu Lys Thr Gln Val Ser Tyr Tyr Ala Glu Arg Leu 
            420                 425                 430         


Ser Arg Ala Ala Lys Asp Arg Ser Ala Thr Gly Leu Glu Arg Thr Leu 
        435                 440                 445             


Ala Ile Leu Ala Asp Lys Thr Arg Gln Leu Val Thr Val Cys Asp Cys 
    450                 455                 460                 


Lys Leu Leu Ala Asn Ser Ile His Gly Leu Asn Ala Ala Arg Pro Asp 
465                 470                 475                 480 


Tyr Ile Ala Ser Lys Ala Ser Pro Thr Ser Thr Glu Glu Glu Gln Val 
                485                 490                 495     


Met Leu Arg Asn Asp Gln Asp Thr Leu Met Ala Arg Trp Thr Gly Arg 
            500                 505                 510         


Asn Ser Arg Ser Ser Leu Gln Val Asp Trp His Glu Glu Glu Trp Glu 
        515                 520                 525             


Lys Val Trp Leu Asn Val Asp Lys Ser Leu Glu Cys Ile Ile Gln Arg 
    530                 535                 540                 


Val Asp Lys Leu Leu Gln Lys Glu Arg Leu His Gly Glu Gly Cys Glu 
545                 550                 555                 560 


Asp Val Phe Pro Cys Ala Gly Ser Cys Thr Ser Lys Lys Asp Cys Ser 
                565                 570                 575     


Pro Pro Pro Glu Glu Ser Ser Pro Gly Glu Trp Ser Glu Ala Leu Tyr 
            580                 585                 590         


Pro Leu Leu Thr Thr Leu Thr Asp Cys Val Ala Met Met Ser Asp Lys 
        595                 600                 605             


Ala Lys Lys Ala Met Val Phe Leu Leu Met Gln Asp Ser Ala Pro Thr 
    610                 615                 620                 


Ile Ala Thr Tyr Leu Ser Leu Gln Tyr Arg Arg Asp Val Val Phe Cys 
625                 630                 635                 640 


Gln Thr Leu Thr Ala Leu Ile Cys Gly Phe Ile Ile Lys Leu Arg Asn 
                645                 650                 655     


Cys Leu His Asp Asp Gly Phe Leu Arg Gln Leu Tyr Thr Ile Gly Leu 
            660                 665                 670         


Leu Ala Gln Phe Glu Ser Leu Leu Ser Thr Tyr Gly Glu Glu Leu Ala 
        675                 680                 685             


Met Leu Glu Asp Met Ser Leu Gly Ile Met Asp Leu Arg Asn Val Thr 
    690                 695                 700                 


Phe Lys Val Thr Gln Ala Thr Ser Ser Ala Ser Ala Asp Met Leu Pro 
705                 710                 715                 720 


Val Ile Thr Gly Asn Arg Asp Gly Phe Asn Val Arg Val Pro Leu Pro 
                725                 730                 735     


Gly Pro Leu Phe Asp Ala Leu Pro Arg Glu Ile Gln Ser Gly Met Leu 
            740                 745                 750         


Leu Arg Val Gln Pro Val Leu Phe Asn Val Gly Ile Asn Glu Gln Gln 
        755                 760                 765             


Thr Leu Ala Glu Arg Phe Gly Asp Thr Ser Leu Gln Glu Val Ile Asn 
    770                 775                 780                 


Val Glu Ser Leu Val Arg Leu Asn Ser Tyr Phe Glu Gln Phe Lys Glu 
785                 790                 795                 800 


Val Leu Pro Glu Asp Cys Leu Pro Arg Ser Arg Ser Gln Thr Cys Leu 
                805                 810                 815     


Pro Glu Leu Leu Arg Phe Leu Gly Gln Asn Val His Ala Arg Lys Asn 
            820                 825                 830         


Lys Asn Val Asp Ile Leu Trp Gln Ala Ala Glu Ile Cys Arg Arg Leu 
        835                 840                 845             


Asn Gly Val Arg Phe Thr Ser Cys Lys Ser Ala Lys Asp Arg Thr Ala 
    850                 855                 860                 


Met Ser Val Thr Leu Glu Gln Cys Leu Ile Leu Gln His Glu His Gly 
865                 870                 875                 880 


Met Ala Pro Gln Val Phe Thr Gln Ala Leu Glu Cys Met Arg Ser Ile 
                885                 890                 895     


Gly Thr Arg Glu Val Val Thr Gln Lys Asn Leu Ser Gly Leu Val Pro 
            900                 905                 910         


Ile Arg Asp Leu Arg Leu Asp Pro Ser Leu Leu Cys Ser Ile Pro Leu 
        915                 920                 925             


Leu Ala Leu Ser Pro Asn Leu Leu Ile Val Trp Leu Phe Leu Ser Ile 
    930                 935                 940                 


Ala Tyr Leu Val Thr Lys Leu Arg Cys Lys 
945                 950                 


<210>  2417
<211>  2436
<212>  PRT
<213>  Homo sapiens

<400>  2417

Met Gly Phe Leu His Gln Leu Gln Leu Leu Leu Trp Lys Asn Val Thr 
1               5                   10                  15      


Leu Lys Arg Arg Ser Pro Trp Val Leu Ala Phe Glu Ile Phe Ile Pro 
            20                  25                  30          


Leu Val Leu Phe Phe Ile Leu Leu Gly Leu Arg Gln Lys Lys Pro Thr 
        35                  40                  45              


Ile Ser Val Lys Glu Val Ser Phe Tyr Thr Ala Ala Pro Leu Thr Ser 
    50                  55                  60                  


Ala Gly Ile Leu Pro Val Met Gln Ser Leu Cys Pro Asp Gly Gln Arg 
65                  70                  75                  80  


Asp Glu Phe Gly Phe Leu Gln Tyr Ala Asn Ser Thr Val Thr Gln Leu 
                85                  90                  95      


Leu Glu Arg Leu Asp Arg Val Val Glu Glu Gly Asn Leu Phe Asp Pro 
            100                 105                 110         


Ala Arg Pro Ser Leu Gly Ser Glu Leu Glu Ala Leu Arg Gln His Leu 
        115                 120                 125             


Glu Ala Leu Ser Ala Gly Pro Gly Thr Ser Gly Ser His Leu Asp Arg 
    130                 135                 140                 


Ser Thr Val Ser Ser Phe Ser Leu Asp Ser Val Ala Arg Asn Pro Gln 
145                 150                 155                 160 


Glu Leu Trp Arg Phe Leu Thr Gln Asn Leu Ser Leu Pro Asn Ser Thr 
                165                 170                 175     


Ala Gln Ala Leu Leu Ala Ala Arg Val Asp Pro Pro Glu Val Tyr His 
            180                 185                 190         


Leu Leu Phe Gly Pro Ser Ser Ala Leu Asp Ser Gln Ser Gly Leu His 
        195                 200                 205             


Lys Gly Gln Glu Pro Trp Ser Arg Leu Gly Gly Asn Pro Leu Phe Arg 
    210                 215                 220                 


Met Glu Glu Leu Leu Leu Ala Pro Ala Leu Leu Glu Gln Leu Thr Cys 
225                 230                 235                 240 


Thr Pro Gly Ser Gly Glu Leu Gly Arg Ile Leu Thr Val Pro Glu Ser 
                245                 250                 255     


Gln Lys Gly Ala Leu Gln Gly Tyr Arg Asp Ala Val Cys Ser Gly Gln 
            260                 265                 270         


Ala Ala Ala Arg Ala Arg Arg Phe Ser Gly Leu Ser Ala Glu Leu Arg 
        275                 280                 285             


Asn Gln Leu Asp Val Ala Lys Val Ser Gln Gln Leu Gly Leu Asp Ala 
    290                 295                 300                 


Pro Asn Gly Ser Asp Ser Ser Pro Gln Ala Pro Pro Pro Arg Arg Leu 
305                 310                 315                 320 


Gln Ala Leu Leu Gly Asp Leu Leu Asp Ala Gln Lys Val Leu Gln Asp 
                325                 330                 335     


Val Asp Val Leu Ser Ala Leu Ala Leu Leu Leu Pro Gln Gly Ala Cys 
            340                 345                 350         


Thr Gly Arg Thr Pro Gly Pro Pro Ala Ser Gly Ala Gly Gly Ala Ala 
        355                 360                 365             


Asn Gly Thr Gly Ala Gly Ala Val Met Gly Pro Asn Ala Thr Ala Glu 
    370                 375                 380                 


Glu Gly Ala Pro Ser Ala Ala Ala Leu Ala Thr Pro Asp Thr Leu Gln 
385                 390                 395                 400 


Gly Gln Cys Ser Ala Phe Val Gln Leu Trp Ala Gly Leu Gln Pro Ile 
                405                 410                 415     


Leu Cys Gly Asn Asn Arg Thr Ile Glu Pro Glu Ala Leu Arg Arg Gly 
            420                 425                 430         


Asn Met Ser Ser Leu Gly Phe Thr Ser Lys Glu Gln Arg Asn Leu Gly 
        435                 440                 445             


Leu Leu Val His Leu Met Thr Ser Asn Pro Lys Ile Leu Tyr Ala Pro 
    450                 455                 460                 


Ala Gly Ser Glu Val Asp Arg Val Ile Leu Lys Ala Asn Glu Thr Phe 
465                 470                 475                 480 


Ala Phe Val Gly Asn Val Thr His Tyr Ala Gln Val Trp Leu Asn Ile 
                485                 490                 495     


Ser Ala Glu Ile Arg Ser Phe Leu Glu Gln Gly Arg Leu Gln Gln His 
            500                 505                 510         


Leu Arg Trp Leu Gln Gln Tyr Val Ala Glu Leu Arg Leu His Pro Glu 
        515                 520                 525             


Ala Leu Asn Leu Ser Leu Asp Glu Leu Pro Pro Ala Leu Arg Gln Asp 
    530                 535                 540                 


Asn Phe Ser Leu Pro Ser Gly Met Ala Leu Leu Gln Gln Leu Asp Thr 
545                 550                 555                 560 


Ile Asp Asn Ala Ala Cys Gly Trp Ile Gln Phe Met Ser Lys Val Ser 
                565                 570                 575     


Val Asp Ile Phe Lys Gly Phe Pro Asp Glu Glu Ser Ile Val Asn Tyr 
            580                 585                 590         


Thr Leu Asn Gln Ala Tyr Gln Asp Asn Val Thr Val Phe Ala Ser Val 
        595                 600                 605             


Ile Phe Gln Thr Arg Lys Asp Gly Ser Leu Pro Pro His Val His Tyr 
    610                 615                 620                 


Lys Ile Arg Gln Asn Ser Ser Phe Thr Glu Lys Thr Asn Glu Ile Arg 
625                 630                 635                 640 


Arg Ala Tyr Trp Arg Pro Gly Pro Asn Thr Gly Gly Arg Phe Tyr Phe 
                645                 650                 655     


Leu Tyr Gly Phe Val Trp Ile Gln Asp Met Met Glu Arg Ala Ile Ile 
            660                 665                 670         


Asp Thr Phe Val Gly His Asp Val Val Glu Pro Gly Ser Tyr Val Gln 
        675                 680                 685             


Met Phe Pro Tyr Pro Cys Tyr Thr Arg Asp Asp Phe Leu Phe Val Ile 
    690                 695                 700                 


Glu His Met Met Pro Leu Cys Met Val Ile Ser Trp Val Tyr Ser Val 
705                 710                 715                 720 


Ala Met Thr Ile Gln His Ile Val Ala Glu Lys Glu His Arg Leu Lys 
                725                 730                 735     


Glu Val Met Lys Thr Met Gly Leu Asn Asn Ala Val His Trp Val Ala 
            740                 745                 750         


Trp Phe Ile Thr Gly Phe Val Gln Leu Ser Ile Ser Val Thr Ala Leu 
        755                 760                 765             


Thr Ala Ile Leu Lys Tyr Gly Gln Val Leu Met His Ser His Val Val 
    770                 775                 780                 


Ile Ile Trp Leu Phe Leu Ala Val Tyr Ala Val Ala Thr Ile Met Phe 
785                 790                 795                 800 


Cys Phe Leu Val Ser Val Leu Tyr Ser Lys Ala Lys Leu Ala Ser Ala 
                805                 810                 815     


Cys Gly Gly Ile Ile Tyr Phe Leu Ser Tyr Val Pro Tyr Met Tyr Val 
            820                 825                 830         


Ala Ile Arg Glu Glu Val Ala His Asp Lys Ile Thr Ala Phe Glu Lys 
        835                 840                 845             


Cys Ile Ala Ser Leu Met Ser Thr Thr Ala Phe Gly Leu Gly Ser Lys 
    850                 855                 860                 


Tyr Phe Ala Leu Tyr Glu Val Ala Gly Val Gly Ile Gln Trp His Thr 
865                 870                 875                 880 


Phe Ser Gln Ser Pro Val Glu Gly Asp Asp Phe Asn Leu Leu Leu Ala 
                885                 890                 895     


Val Thr Met Leu Met Val Asp Ala Val Val Tyr Gly Ile Leu Thr Trp 
            900                 905                 910         


Tyr Ile Glu Ala Val His Pro Gly Met Tyr Gly Leu Pro Arg Pro Trp 
        915                 920                 925             


Tyr Phe Pro Leu Gln Lys Ser Tyr Trp Leu Gly Ser Gly Arg Thr Glu 
    930                 935                 940                 


Ala Trp Glu Trp Ser Trp Pro Trp Ala Arg Thr Pro Arg Leu Ser Val 
945                 950                 955                 960 


Met Glu Glu Asp Gln Ala Cys Ala Met Glu Ser Arg Arg Phe Glu Glu 
                965                 970                 975     


Thr Arg Gly Met Glu Glu Glu Pro Thr His Leu Pro Leu Val Val Cys 
            980                 985                 990         


Val Asp Lys Leu Thr Lys Val Tyr  Lys Asp Asp Lys Lys  Leu Ala Leu 
        995                 1000                 1005             


Asn Lys  Leu Ser Leu Asn Leu  Tyr Glu Asn Gln Val  Val Ser Phe 
    1010                 1015                 1020             


Leu Gly  His Asn Gly Ala Gly  Lys Thr Thr Thr Met  Ser Ile Leu 
    1025                 1030                 1035             


Thr Gly  Leu Phe Pro Pro Thr  Ser Gly Ser Ala Thr  Ile Tyr Gly 
    1040                 1045                 1050             


His Asp  Ile Arg Thr Glu Met  Asp Glu Ile Arg Lys  Asn Leu Gly 
    1055                 1060                 1065             


Met Cys  Pro Gln His Asn Val  Leu Phe Asp Arg Leu  Thr Val Glu 
    1070                 1075                 1080             


Glu His  Leu Trp Phe Tyr Ser  Arg Leu Lys Ser Met  Ala Gln Glu 
    1085                 1090                 1095             


Glu Ile  Arg Arg Glu Met Asp  Lys Met Ile Glu Asp  Leu Glu Leu 
    1100                 1105                 1110             


Ser Asn  Lys Arg His Ser Leu  Val Gln Thr Leu Ser  Gly Gly Met 
    1115                 1120                 1125             


Lys Arg  Lys Leu Ser Val Ala  Ile Ala Phe Val Gly  Gly Ser Arg 
    1130                 1135                 1140             


Ala Ile  Ile Leu Asp Glu Pro  Thr Ala Gly Val Asp  Pro Tyr Ala 
    1145                 1150                 1155             


Arg Arg  Ala Ile Trp Asp Leu  Ile Leu Lys Tyr Lys  Pro Gly Arg 
    1160                 1165                 1170             


Thr Ile  Leu Leu Ser Thr His  His Met Asp Glu Ala  Asp Leu Leu 
    1175                 1180                 1185             


Gly Asp  Arg Ile Ala Ile Ile  Ser His Gly Lys Leu  Lys Cys Cys 
    1190                 1195                 1200             


Gly Ser  Pro Leu Phe Leu Lys  Gly Thr Tyr Gly Asp  Gly Tyr Arg 
    1205                 1210                 1215             


Leu Thr  Leu Val Lys Arg Pro  Ala Glu Pro Gly Gly  Pro Gln Glu 
    1220                 1225                 1230             


Pro Gly  Leu Ala Ser Ser Pro  Pro Gly Arg Ala Pro  Leu Ser Ser 
    1235                 1240                 1245             


Cys Ser  Glu Leu Gln Val Ser  Gln Phe Ile Arg Lys  His Val Ala 
    1250                 1255                 1260             


Ser Cys  Leu Leu Val Ser Asp  Thr Ser Thr Glu Leu  Ser Tyr Ile 
    1265                 1270                 1275             


Leu Pro  Ser Glu Ala Ala Lys  Lys Gly Ala Phe Glu  Arg Leu Phe 
    1280                 1285                 1290             


Gln His  Leu Glu Arg Ser Leu  Asp Ala Leu His Leu  Ser Ser Phe 
    1295                 1300                 1305             


Gly Leu  Met Asp Thr Thr Leu  Glu Glu Val Phe Leu  Lys Val Ser 
    1310                 1315                 1320             


Glu Glu  Asp Gln Ser Leu Glu  Asn Ser Glu Ala Asp  Val Lys Glu 
    1325                 1330                 1335             


Ser Arg  Lys Asp Val Leu Pro  Gly Ala Glu Gly Pro  Ala Ser Gly 
    1340                 1345                 1350             


Glu Gly  His Ala Gly Asn Leu  Ala Arg Cys Ser Glu  Leu Thr Gln 
    1355                 1360                 1365             


Ser Gln  Ala Ser Leu Gln Ser  Ala Ser Ser Val Gly  Ser Ala Arg 
    1370                 1375                 1380             


Gly Asp  Glu Gly Ala Gly Tyr  Thr Asp Val Tyr Gly  Asp Tyr Arg 
    1385                 1390                 1395             


Pro Leu  Phe Asp Asn Pro Gln  Asp Pro Asp Asn Val  Ser Leu Gln 
    1400                 1405                 1410             


Glu Val  Glu Ala Glu Ala Leu  Ser Arg Val Gly Gln  Gly Ser Arg 
    1415                 1420                 1425             


Lys Leu  Asp Gly Gly Trp Leu  Lys Val Arg Gln Phe  His Gly Leu 
    1430                 1435                 1440             


Leu Val  Lys Arg Phe His Cys  Ala Arg Arg Asn Ser  Lys Ala Leu 
    1445                 1450                 1455             


Phe Ser  Gln Ile Leu Leu Pro  Ala Phe Phe Val Cys  Val Ala Met 
    1460                 1465                 1470             


Thr Val  Ala Leu Ser Val Pro  Glu Ile Gly Asp Leu  Pro Pro Leu 
    1475                 1480                 1485             


Val Leu  Ser Pro Ser Gln Tyr  His Asn Tyr Thr Gln  Pro Arg Gly 
    1490                 1495                 1500             


Asn Phe  Ile Pro Tyr Ala Asn  Glu Glu Arg Arg Glu  Tyr Arg Leu 
    1505                 1510                 1515             


Arg Leu  Ser Pro Asp Ala Ser  Pro Gln Gln Leu Val  Ser Thr Phe 
    1520                 1525                 1530             


Arg Leu  Pro Ser Gly Val Gly  Ala Thr Cys Val Leu  Lys Ser Pro 
    1535                 1540                 1545             


Ala Asn  Gly Ser Leu Gly Pro  Thr Leu Asn Leu Ser  Ser Gly Glu 
    1550                 1555                 1560             


Ser Arg  Leu Leu Ala Ala Arg  Phe Phe Asp Ser Met  Cys Leu Glu 
    1565                 1570                 1575             


Ser Phe  Thr Gln Gly Leu Pro  Leu Ser Asn Phe Val  Pro Pro Pro 
    1580                 1585                 1590             


Pro Ser  Pro Ala Pro Ser Asp  Ser Pro Ala Ser Pro  Asp Glu Asp 
    1595                 1600                 1605             


Leu Gln  Ala Trp Asn Val Ser  Leu Pro Pro Thr Ala  Gly Pro Glu 
    1610                 1615                 1620             


Met Trp  Thr Ser Ala Pro Ser  Leu Pro Arg Leu Val  Arg Glu Pro 
    1625                 1630                 1635             


Val Arg  Cys Thr Cys Ser Ala  Gln Gly Thr Gly Phe  Ser Cys Pro 
    1640                 1645                 1650             


Ser Ser  Val Gly Gly His Pro  Pro Gln Met Arg Val  Val Thr Gly 
    1655                 1660                 1665             


Asp Ile  Leu Thr Asp Ile Thr  Gly His Asn Val Ser  Glu Tyr Leu 
    1670                 1675                 1680             


Leu Phe  Thr Ser Asp Arg Phe  Arg Leu His Arg Tyr  Gly Ala Ile 
    1685                 1690                 1695             


Thr Phe  Gly Asn Val Leu Lys  Ser Ile Pro Ala Ser  Phe Gly Thr 
    1700                 1705                 1710             


Arg Ala  Pro Pro Met Val Arg  Lys Ile Ala Val Arg  Arg Ala Ala 
    1715                 1720                 1725             


Gln Val  Phe Tyr Asn Asn Lys  Gly Tyr His Ser Met  Pro Thr Tyr 
    1730                 1735                 1740             


Leu Asn  Ser Leu Asn Asn Ala  Ile Leu Arg Ala Asn  Leu Pro Lys 
    1745                 1750                 1755             


Ser Lys  Gly Asn Pro Ala Ala  Tyr Gly Ile Thr Val  Thr Asn His 
    1760                 1765                 1770             


Pro Met  Asn Lys Thr Ser Ala  Ser Leu Ser Leu Asp  Tyr Leu Leu 
    1775                 1780                 1785             


Gln Gly  Thr Asp Val Val Ile  Ala Ile Phe Ile Ile  Val Ala Met 
    1790                 1795                 1800             


Ser Phe  Val Pro Ala Ser Phe  Val Val Phe Leu Val  Ala Glu Lys 
    1805                 1810                 1815             


Ser Thr  Lys Ala Lys His Leu  Gln Phe Val Ser Gly  Cys Asn Pro 
    1820                 1825                 1830             


Ile Ile  Tyr Trp Leu Ala Asn  Tyr Val Trp Asp Met  Leu Asn Tyr 
    1835                 1840                 1845             


Leu Val  Pro Ala Thr Cys Cys  Val Ile Ile Leu Phe  Val Phe Asp 
    1850                 1855                 1860             


Leu Pro  Ala Tyr Thr Ser Pro  Thr Asn Phe Pro Ala  Val Leu Ser 
    1865                 1870                 1875             


Leu Phe  Leu Leu Tyr Gly Trp  Ser Ile Thr Pro Ile  Met Tyr Pro 
    1880                 1885                 1890             


Ala Ser  Phe Trp Phe Glu Val  Pro Ser Ser Ala Tyr  Val Phe Leu 
    1895                 1900                 1905             


Ile Val  Ile Asn Leu Phe Ile  Gly Ile Thr Ala Thr  Val Ala Thr 
    1910                 1915                 1920             


Phe Leu  Leu Gln Leu Phe Glu  His Asp Lys Asp Leu  Lys Val Val 
    1925                 1930                 1935             


Asn Ser  Tyr Leu Lys Ser Cys  Phe Leu Ile Phe Pro  Asn Tyr Asn 
    1940                 1945                 1950             


Leu Gly  His Gly Leu Met Glu  Met Ala Tyr Asn Glu  Tyr Ile Asn 
    1955                 1960                 1965             


Glu Tyr  Tyr Ala Lys Ile Gly  Gln Phe Asp Lys Met  Lys Ser Pro 
    1970                 1975                 1980             


Phe Glu  Trp Asp Ile Val Thr  Arg Gly Leu Val Ala  Met Ala Val 
    1985                 1990                 1995             


Glu Gly  Val Val Gly Phe Leu  Leu Thr Ile Met Cys  Gln Tyr Asn 
    2000                 2005                 2010             


Phe Leu  Arg Arg Pro Gln Arg  Met Pro Val Ser Thr  Lys Pro Val 
    2015                 2020                 2025             


Glu Asp  Asp Val Asp Val Ala  Ser Glu Arg Gln Arg  Val Leu Arg 
    2030                 2035                 2040             


Gly Asp  Ala Asp Asn Asp Met  Val Lys Ile Glu Asn  Leu Thr Lys 
    2045                 2050                 2055             


Val Tyr  Lys Ser Arg Lys Ile  Gly Arg Ile Leu Ala  Val Asp Arg 
    2060                 2065                 2070             


Leu Cys  Leu Gly Val Arg Pro  Gly Glu Cys Phe Gly  Leu Leu Gly 
    2075                 2080                 2085             


Val Asn  Gly Ala Gly Lys Thr  Ser Thr Phe Lys Met  Leu Thr Gly 
    2090                 2095                 2100             


Asp Glu  Ser Thr Thr Gly Gly  Glu Ala Phe Val Asn  Gly His Ser 
    2105                 2110                 2115             


Val Leu  Lys Glu Leu Leu Gln  Val Gln Gln Ser Leu  Gly Tyr Cys 
    2120                 2125                 2130             


Pro Gln  Cys Asp Ala Leu Phe  Asp Glu Leu Thr Ala  Arg Glu His 
    2135                 2140                 2145             


Leu Gln  Leu Tyr Thr Arg Leu  Arg Gly Ile Ser Trp  Lys Asp Glu 
    2150                 2155                 2160             


Ala Arg  Val Val Lys Trp Ala  Leu Glu Lys Leu Glu  Leu Thr Lys 
    2165                 2170                 2175             


Tyr Ala  Asp Lys Pro Ala Gly  Thr Tyr Ser Gly Gly  Asn Lys Arg 
    2180                 2185                 2190             


Lys Leu  Ser Thr Ala Ile Ala  Leu Ile Gly Tyr Pro  Ala Phe Ile 
    2195                 2200                 2205             


Phe Leu  Asp Glu Pro Thr Thr  Gly Met Asp Pro Lys  Ala Arg Arg 
    2210                 2215                 2220             


Phe Leu  Trp Asn Leu Ile Leu  Asp Leu Ile Lys Thr  Gly Arg Ser 
    2225                 2230                 2235             


Val Val  Leu Thr Ser His Ser  Met Glu Glu Cys Glu  Ala Leu Cys 
    2240                 2245                 2250             


Thr Arg  Leu Ala Ile Met Val  Asn Gly Arg Leu Arg  Cys Leu Gly 
    2255                 2260                 2265             


Ser Ile  Gln His Leu Lys Asn  Arg Phe Gly Asp Gly  Tyr Met Ile 
    2270                 2275                 2280             


Thr Val  Arg Thr Lys Ser Ser  Gln Ser Val Lys Asp  Val Val Arg 
    2285                 2290                 2295             


Phe Phe  Asn Arg Asn Phe Pro  Glu Ala Met Leu Lys  Glu Arg His 
    2300                 2305                 2310             


His Thr  Lys Val Gln Tyr Gln  Leu Lys Ser Glu His  Ile Ser Leu 
    2315                 2320                 2325             


Ala Gln  Val Phe Ser Lys Met  Glu Gln Val Ser Gly  Val Leu Gly 
    2330                 2335                 2340             


Ile Glu  Asp Tyr Ser Val Ser  Gln Thr Thr Leu Asp  Asn Val Phe 
    2345                 2350                 2355             


Val Asn  Phe Ala Lys Lys Gln  Ser Asp Asn Leu Glu  Gln Gln Glu 
    2360                 2365                 2370             


Thr Glu  Pro Pro Ser Ala Leu  Gln Ser Pro Leu Gly  Cys Leu Leu 
    2375                 2380                 2385             


Ser Leu  Leu Arg Pro Arg Ser  Ala Pro Thr Glu Leu  Arg Ala Leu 
    2390                 2395                 2400             


Val Ala  Asp Glu Pro Glu Asp  Leu Asp Thr Glu Asp  Glu Gly Leu 
    2405                 2410                 2415             


Ile Ser  Phe Glu Glu Glu Arg  Ala Gln Leu Ser Phe  Asn Thr Asp 
    2420                 2425                 2430             


Thr Leu  Cys 
    2435     


<210>  2418
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  2418

Met Ala Gly Lys Arg Ser Gly Trp Ser Arg Ala Ala Leu Leu Gln Leu 
1               5                   10                  15      


Leu Leu Gly Val Asn Leu Val Val Met Pro Pro Thr Arg Ala Arg Ser 
            20                  25                  30          


Leu Arg Phe Val Thr Leu Leu Tyr Arg His Gly Asp Arg Ser Pro Val 
        35                  40                  45              


Lys Thr Tyr Pro Lys Asp Pro Tyr Gln Glu Glu Glu Trp Pro Gln Gly 
    50                  55                  60                  


Phe Gly Gln Leu Thr Lys Glu Gly Met Leu Gln His Trp Glu Leu Gly 
65                  70                  75                  80  


Gln Ala Leu Arg Gln Arg Tyr His Gly Phe Leu Asn Thr Ser Tyr His 
                85                  90                  95      


Arg Gln Glu Val Tyr Val Arg Ser Thr Asp Phe Asp Arg Thr Leu Met 
            100                 105                 110         


Ser Ala Glu Ala Asn Leu Ala Gly Leu Phe Pro Pro Asn Gly Met Gln 
        115                 120                 125             


Arg Phe Asn Pro Asn Ile Ser Trp Gln Pro Ile Pro Val His Thr Val 
    130                 135                 140                 


Pro Ile Thr Glu Asp Arg Leu Leu Lys Phe Pro Leu Gly Pro Cys Pro 
145                 150                 155                 160 


Arg Tyr Glu Gln Leu Gln Asn Glu Thr Arg Gln Thr Pro Glu Tyr Gln 
                165                 170                 175     


Asn Glu Ser Ser Arg Asn Ala Gln Phe Leu Asp Met Val Ala Asn Glu 
            180                 185                 190         


Thr Gly Leu Thr Asp Leu Thr Leu Glu Thr Val Trp Asn Val Tyr Asp 
        195                 200                 205             


Thr Leu Phe Cys Glu Gln Thr His Gly Leu Arg Leu Pro Pro Trp Ala 
    210                 215                 220                 


Ser Pro Gln Thr Met Gln Arg Leu Ser Arg Leu Lys Asp Phe Ser Phe 
225                 230                 235                 240 


Arg Phe Leu Phe Gly Ile Tyr Gln Gln Ala Glu Lys Ala Arg Leu Gln 
                245                 250                 255     


Gly Gly Val Leu Leu Ala Gln Ile Arg Lys Asn Leu Thr Leu Met Ala 
            260                 265                 270         


Thr Thr Ser Gln Leu Pro Lys Leu Leu Val Tyr Ser Ala His Asp Thr 
        275                 280                 285             


Thr Leu Val Ala Leu Gln Met Ala Leu Asp Val Tyr Asn Gly Glu Gln 
    290                 295                 300                 


Ala Pro Tyr Ala Ser Cys His Ile Phe Glu Leu Tyr Gln Glu Asp Ser 
305                 310                 315                 320 


Gly Asn Phe Ser Val Glu Met Tyr Phe Arg Asn Glu Ser Asp Lys Ala 
                325                 330                 335     


Pro Trp Pro Leu Ser Leu Pro Gly Cys Pro His Arg Cys Pro Leu Gln 
            340                 345                 350         


Asp Phe Leu Arg Leu Thr Glu Pro Val Val Pro Lys Asp Trp Gln Gln 
        355                 360                 365             


Glu Cys Gln Leu Ala Ser Gly Pro Ala Asp Thr Glu Val Ile Val Ala 
    370                 375                 380                 


Leu Ala Val Cys Gly Ser Ile Leu Phe Leu Leu Ile Val Leu Leu Leu 
385                 390                 395                 400 


Thr Val Leu Phe Arg Met Gln Ala Gln Pro Pro Gly Tyr Arg His Val 
                405                 410                 415     


Ala Asp Gly Glu Asp His Ala 
            420             


<210>  2419
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  2419

Met Gly Ala Ala Ala Lys Leu Ala Phe Ala Val Phe Leu Ile Ser Cys 
1               5                   10                  15      


Ser Ser Gly Ala Ile Leu Gly Arg Ser Glu Thr Gln Glu Cys Leu Phe 
            20                  25                  30          


Phe Asn Ala Asn Trp Glu Lys Asp Arg Thr Asn Gln Thr Gly Val Glu 
        35                  40                  45              


Pro Cys Tyr Gly Asp Lys Asp Lys Arg Arg His Cys Phe Ala Thr Trp 
    50                  55                  60                  


Lys Asn Ile Ser Gly Ser Ile Glu Ile Val Lys Gln Gly Cys Trp Leu 
65                  70                  75                  80  


Asp Asp Ile Asn Cys Tyr Asp Arg Thr Asp Cys Val Glu Lys Lys Asp 
                85                  90                  95      


Ser Pro Glu Val Tyr Phe Cys Cys Cys Glu Gly Asn Met Cys Asn Glu 
            100                 105                 110         


Lys Phe Ser Tyr Phe Pro Glu Met Glu Val Thr Gln Pro Thr Ser Asn 
        115                 120                 125             


Pro Val Thr Pro Lys Pro Pro Tyr Tyr Asn Ile Leu Leu Tyr Ser Leu 
    130                 135                 140                 


Val Pro Leu Met Leu Ile Ala Gly Ile Val Ile Cys Ala Phe Trp Val 
145                 150                 155                 160 


Tyr Arg His His Lys Met Ala Tyr Pro Pro Val Leu Val Pro Thr Gln 
                165                 170                 175     


Asp Pro Gly Pro Pro Pro Pro Ser Pro Leu Leu Gly Leu Lys Pro Leu 
            180                 185                 190         


Gln Leu Leu Glu Val Lys Ala Arg Gly Arg Phe Gly Cys Val Trp Lys 
        195                 200                 205             


Ala Gln Leu Leu Asn Glu Tyr Val Ala Val Lys Ile Phe Pro Ile Gln 
    210                 215                 220                 


Asp Lys Gln Ser Trp Gln Asn Glu Tyr Glu Val Tyr Ser Leu Pro Gly 
225                 230                 235                 240 


Met Lys His Glu Asn Ile Leu Gln Phe Ile Gly Ala Glu Lys Arg Gly 
                245                 250                 255     


Thr Ser Val Asp Val Asp Leu Trp Leu Ile Thr Ala Phe His Glu Lys 
            260                 265                 270         


Gly Ser Leu Ser Asp Phe Leu Lys Ala Asn Val Val Ser Trp Asn Glu 
        275                 280                 285             


Leu Cys His Ile Ala Glu Thr Met Ala Arg Gly Leu Ala Tyr Leu His 
    290                 295                 300                 


Glu Asp Ile Pro Gly Leu Lys Asp Gly His Lys Pro Ala Ile Ser His 
305                 310                 315                 320 


Arg Asp Ile Lys Ser Lys Asn Val Leu Leu Lys Asn Asn Leu Thr Ala 
                325                 330                 335     


Cys Ile Ala Asp Phe Gly Leu Ala Leu Lys Phe Glu Ala Gly Lys Ser 
            340                 345                 350         


Ala Gly Asp Thr His Gly Gln Val Gly Thr Arg Arg Tyr Met Ala Pro 
        355                 360                 365             


Glu Val Leu Glu Gly Ala Ile Asn Phe Gln Arg Asp Ala Phe Leu Arg 
    370                 375                 380                 


Ile Asp Met Tyr Ala Met Gly Leu Val Leu Trp Glu Leu Ala Ser Arg 
385                 390                 395                 400 


Cys Thr Ala Ala Asp Gly Pro Val Asp Glu Tyr Met Leu Pro Phe Glu 
                405                 410                 415     


Glu Glu Ile Gly Gln His Pro Ser Leu Glu Asp Met Gln Glu Val Val 
            420                 425                 430         


Val His Lys Lys Lys Arg Pro Val Leu Arg Asp Tyr Trp Gln Lys His 
        435                 440                 445             


Ala Gly Met Ala Met Leu Cys Glu Thr Ile Glu Glu Cys Trp Asp His 
    450                 455                 460                 


Asp Ala Glu Ala Arg Leu Ser Ala Gly Cys Val Gly Glu Arg Ile Thr 
465                 470                 475                 480 


Gln Met Gln Arg Leu Thr Asn Ile Ile Thr Thr Glu Asp Ile Val Thr 
                485                 490                 495     


Val Val Thr Met Val Thr Asn Val Asp Phe Pro Pro Lys Glu Ser Ser 
            500                 505                 510         


Leu 
    


<210>  2420
<211>  583
<212>  PRT
<213>  Homo sapiens

<400>  2420

Met Glu Ser Lys Gly Ala Ser Ser Cys Arg Leu Leu Phe Cys Leu Leu 
1               5                   10                  15      


Ile Ser Ala Thr Val Phe Arg Pro Gly Leu Gly Trp Tyr Thr Val Asn 
            20                  25                  30          


Ser Ala Tyr Gly Asp Thr Ile Ile Ile Pro Cys Arg Leu Asp Val Pro 
        35                  40                  45              


Gln Asn Leu Met Phe Gly Lys Trp Lys Tyr Glu Lys Pro Asp Gly Ser 
    50                  55                  60                  


Pro Val Phe Ile Ala Phe Arg Ser Ser Thr Lys Lys Ser Val Gln Tyr 
65                  70                  75                  80  


Asp Asp Val Pro Glu Tyr Lys Asp Arg Leu Asn Leu Ser Glu Asn Tyr 
                85                  90                  95      


Thr Leu Ser Ile Ser Asn Ala Arg Ile Ser Asp Glu Lys Arg Phe Val 
            100                 105                 110         


Cys Met Leu Val Thr Glu Asp Asn Val Phe Glu Ala Pro Thr Ile Val 
        115                 120                 125             


Lys Val Phe Lys Gln Pro Ser Lys Pro Glu Ile Val Ser Lys Ala Leu 
    130                 135                 140                 


Phe Leu Glu Thr Glu Gln Leu Lys Lys Leu Gly Asp Cys Ile Ser Glu 
145                 150                 155                 160 


Asp Ser Tyr Pro Asp Gly Asn Ile Thr Trp Tyr Arg Asn Gly Lys Val 
                165                 170                 175     


Leu His Pro Leu Glu Gly Ala Val Val Ile Ile Phe Lys Lys Glu Met 
            180                 185                 190         


Asp Pro Val Thr Gln Leu Tyr Thr Met Thr Ser Thr Leu Glu Tyr Lys 
        195                 200                 205             


Thr Thr Lys Ala Asp Ile Gln Met Pro Phe Thr Cys Ser Val Thr Tyr 
    210                 215                 220                 


Tyr Gly Pro Ser Gly Gln Lys Thr Ile His Ser Glu Gln Ala Val Phe 
225                 230                 235                 240 


Asp Ile Tyr Tyr Pro Thr Glu Gln Val Thr Ile Gln Val Leu Pro Pro 
                245                 250                 255     


Lys Asn Ala Ile Lys Glu Gly Asp Asn Ile Thr Leu Lys Cys Leu Gly 
            260                 265                 270         


Asn Gly Asn Pro Pro Pro Glu Glu Phe Leu Phe Tyr Leu Pro Gly Gln 
        275                 280                 285             


Pro Glu Gly Ile Arg Ser Ser Asn Thr Tyr Thr Leu Thr Asp Val Arg 
    290                 295                 300                 


Arg Asn Ala Thr Gly Asp Tyr Lys Cys Ser Leu Ile Asp Lys Lys Ser 
305                 310                 315                 320 


Met Ile Ala Ser Thr Ala Ile Thr Val His Tyr Leu Asp Leu Ser Leu 
                325                 330                 335     


Asn Pro Ser Gly Glu Val Thr Arg Gln Ile Gly Asp Ala Leu Pro Val 
            340                 345                 350         


Ser Cys Thr Ile Ser Ala Ser Arg Asn Ala Thr Val Val Trp Met Lys 
        355                 360                 365             


Asp Asn Ile Arg Leu Arg Ser Ser Pro Ser Phe Ser Ser Leu His Tyr 
    370                 375                 380                 


Gln Asp Ala Gly Asn Tyr Val Cys Glu Thr Ala Leu Gln Glu Val Glu 
385                 390                 395                 400 


Gly Leu Lys Lys Arg Glu Ser Leu Thr Leu Ile Val Glu Gly Lys Pro 
                405                 410                 415     


Gln Ile Lys Met Thr Lys Lys Thr Asp Pro Ser Gly Leu Ser Lys Thr 
            420                 425                 430         


Ile Ile Cys His Val Glu Gly Phe Pro Lys Pro Ala Ile Gln Trp Thr 
        435                 440                 445             


Ile Thr Gly Ser Gly Ser Val Ile Asn Gln Thr Glu Glu Ser Pro Tyr 
    450                 455                 460                 


Ile Asn Gly Arg Tyr Tyr Ser Lys Ile Ile Ile Ser Pro Glu Glu Asn 
465                 470                 475                 480 


Val Thr Leu Thr Cys Thr Ala Glu Asn Gln Leu Glu Arg Thr Val Asn 
                485                 490                 495     


Ser Leu Asn Val Ser Ala Ile Ser Ile Pro Glu His Asp Glu Ala Asp 
            500                 505                 510         


Glu Ile Ser Asp Glu Asn Arg Glu Lys Val Asn Asp Gln Ala Lys Leu 
        515                 520                 525             


Ile Val Gly Ile Val Val Gly Leu Leu Leu Ala Ala Leu Val Ala Gly 
    530                 535                 540                 


Val Val Tyr Trp Leu Tyr Met Lys Lys Ser Lys Thr Ala Ser Lys His 
545                 550                 555                 560 


Val Asn Lys Asp Leu Gly Asn Met Glu Glu Asn Lys Lys Leu Glu Glu 
                565                 570                 575     


Asn Asn His Lys Thr Glu Ala 
            580             


<210>  2421
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  2421

Met Asp Gln Glu Thr Val Gly Asn Val Val Leu Leu Ala Ile Val Thr 
1               5                   10                  15      


Leu Ile Ser Val Val Gln Asn Gly Phe Phe Ala His Lys Val Glu His 
            20                  25                  30          


Glu Ser Arg Thr Gln Asn Gly Arg Ser Phe Gln Arg Thr Gly Thr Leu 
        35                  40                  45              


Ala Phe Glu Arg Val Tyr Thr Ala Asn Gln Asn Cys Val Asp Ala Tyr 
    50                  55                  60                  


Pro Thr Phe Leu Ala Val Leu Trp Ser Ala Gly Leu Leu Cys Ser Gln 
65                  70                  75                  80  


Val Pro Ala Ala Phe Ala Gly Leu Met Tyr Leu Phe Val Arg Gln Lys 
                85                  90                  95      


Tyr Phe Val Gly Tyr Leu Gly Glu Arg Thr Gln Ser Thr Pro Gly Tyr 
            100                 105                 110         


Ile Phe Gly Lys Arg Ile Ile Leu Phe Leu Phe Leu Met Ser Val Ala 
        115                 120                 125             


Gly Ile Phe Asn Tyr Tyr Leu Ile Phe Phe Phe Gly Ser Asp Phe Glu 
    130                 135                 140                 


Asn Tyr Ile Lys Thr Ile Ser Thr Thr Ile Ser Pro Leu Leu Leu Ile 
145                 150                 155                 160 


Pro 
    


<210>  2422
<211>  763
<212>  PRT
<213>  Homo sapiens

<400>  2422

Met Ala Ala Thr Gly Thr Ala Ala Ala Ala Ala Thr Gly Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Gly Leu Thr Ala Pro Ala Leu Ala Leu Ala Gly 
            20                  25                  30          


Tyr Ile Glu Ala Leu Ala Ala Asn Ala Gly Thr Gly Phe Ala Val Ala 
        35                  40                  45              


Glu Pro Gln Ile Ala Met Phe Cys Gly Lys Leu Asn Met His Val Asn 
    50                  55                  60                  


Ile Gln Thr Gly Lys Trp Glu Pro Asp Pro Thr Gly Thr Lys Ser Cys 
65                  70                  75                  80  


Phe Glu Thr Lys Glu Glu Val Leu Gln Tyr Cys Gln Glu Met Tyr Pro 
                85                  90                  95      


Glu Leu Gln Ile Thr Asn Val Met Glu Ala Asn Gln Arg Val Ser Ile 
            100                 105                 110         


Asp Asn Trp Cys Arg Arg Asp Lys Lys Gln Cys Lys Ser Arg Phe Val 
        115                 120                 125             


Thr Pro Phe Lys Cys Leu Val Gly Glu Phe Val Ser Asp Val Leu Leu 
    130                 135                 140                 


Val Pro Glu Lys Cys Gln Phe Phe His Lys Glu Arg Met Glu Val Cys 
145                 150                 155                 160 


Glu Asn His Gln His Trp His Thr Val Val Lys Glu Ala Cys Leu Thr 
                165                 170                 175     


Gln Gly Met Thr Leu Tyr Ser Tyr Gly Met Leu Leu Pro Cys Gly Val 
            180                 185                 190         


Asp Gln Phe His Gly Thr Glu Tyr Val Cys Cys Pro Gln Thr Lys Ile 
        195                 200                 205             


Ile Gly Ser Val Ser Lys Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu 
    210                 215                 220                 


Glu Glu Glu Asp Glu Glu Glu Asp Tyr Asp Val Tyr Lys Ser Glu Phe 
225                 230                 235                 240 


Pro Thr Glu Ala Asp Leu Glu Asp Phe Thr Glu Ala Ala Val Asp Glu 
                245                 250                 255     


Asp Asp Glu Asp Glu Glu Glu Gly Glu Glu Val Val Glu Asp Arg Asp 
            260                 265                 270         


Tyr Tyr Tyr Asp Thr Phe Lys Gly Asp Asp Tyr Asn Glu Glu Asn Pro 
        275                 280                 285             


Thr Glu Pro Gly Ser Asp Gly Thr Met Ser Asp Lys Glu Ile Thr His 
    290                 295                 300                 


Asp Val Lys Ala Val Cys Ser Gln Glu Ala Met Thr Gly Pro Cys Arg 
305                 310                 315                 320 


Ala Val Met Pro Arg Trp Tyr Phe Asp Leu Ser Lys Gly Lys Cys Val 
                325                 330                 335     


Arg Phe Ile Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Glu Ser 
            340                 345                 350         


Glu Asp Tyr Cys Met Ala Val Cys Lys Ala Met Ile Pro Pro Thr Pro 
        355                 360                 365             


Leu Pro Thr Asn Asp Val Asp Val Tyr Phe Glu Thr Ser Ala Asp Asp 
    370                 375                 380                 


Asn Glu His Ala Arg Phe Gln Lys Ala Lys Glu Gln Leu Glu Ile Arg 
385                 390                 395                 400 


His Arg Asn Arg Met Asp Arg Val Lys Lys Glu Trp Glu Glu Ala Glu 
                405                 410                 415     


Leu Gln Ala Lys Asn Leu Pro Lys Ala Glu Arg Gln Thr Leu Ile Gln 
            420                 425                 430         


His Phe Gln Ala Met Val Lys Ala Leu Glu Lys Glu Ala Ala Ser Glu 
        435                 440                 445             


Lys Gln Gln Leu Val Glu Thr His Leu Ala Arg Val Glu Ala Met Leu 
    450                 455                 460                 


Asn Asp Arg Arg Arg Met Ala Leu Glu Asn Tyr Leu Ala Ala Leu Gln 
465                 470                 475                 480 


Ser Asp Pro Pro Arg Pro His Arg Ile Leu Gln Ala Leu Arg Arg Tyr 
                485                 490                 495     


Val Arg Ala Glu Asn Lys Asp Arg Leu His Thr Ile Arg His Tyr Gln 
            500                 505                 510         


His Val Leu Ala Val Asp Pro Glu Lys Ala Ala Gln Met Lys Ser Gln 
        515                 520                 525             


Val Met Thr His Leu His Val Ile Glu Glu Arg Arg Asn Gln Ser Leu 
    530                 535                 540                 


Ser Leu Leu Tyr Lys Val Pro Tyr Val Ala Gln Glu Ile Gln Glu Glu 
545                 550                 555                 560 


Ile Asp Glu Leu Leu Gln Glu Gln Arg Ala Asp Met Asp Gln Phe Thr 
                565                 570                 575     


Ala Ser Ile Ser Glu Thr Pro Val Asp Val Arg Val Ser Ser Glu Glu 
            580                 585                 590         


Ser Glu Glu Ile Pro Pro Phe His Pro Phe His Pro Phe Pro Ala Leu 
        595                 600                 605             


Pro Glu Asn Glu Asp Thr Gln Pro Glu Leu Tyr His Pro Met Lys Lys 
    610                 615                 620                 


Gly Ser Gly Val Gly Glu Gln Asp Gly Gly Leu Ile Gly Ala Glu Glu 
625                 630                 635                 640 


Lys Val Ile Asn Ser Lys Asn Lys Val Asp Glu Asn Met Val Ile Asp 
                645                 650                 655     


Glu Thr Leu Asp Val Lys Glu Met Ile Phe Asn Ala Glu Arg Val Gly 
            660                 665                 670         


Gly Leu Glu Glu Glu Arg Glu Ser Val Gly Pro Leu Arg Glu Asp Phe 
        675                 680                 685             


Ser Leu Ser Ser Ser Ala Leu Ile Gly Leu Leu Val Ile Ala Val Ala 
    690                 695                 700                 


Ile Ala Thr Val Ile Val Ile Ser Leu Val Met Leu Arg Lys Arg Gln 
705                 710                 715                 720 


Tyr Gly Thr Ile Ser His Gly Ile Val Glu Val Asp Pro Met Leu Thr 
                725                 730                 735     


Pro Glu Glu Arg His Leu Asn Lys Met Gln Asn His Gly Tyr Glu Asn 
            740                 745                 750         


Pro Thr Tyr Lys Tyr Leu Glu Gln Met Gln Ile 
        755                 760             


<210>  2423
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  2423

Met Arg Leu Phe Leu Ser Leu Pro Val Leu Val Val Val Leu Ser Ile 
1               5                   10                  15      


Val Leu Glu Gly Pro Ala Pro Ala Gln Gly Thr Pro Asp Val Ser Ser 
            20                  25                  30          


Ala Leu Asp Lys Leu Lys Glu Phe Gly Asn Thr Leu Glu Asp Lys Ala 
        35                  40                  45              


Arg Glu Leu Ile Ser Arg Ile Lys Gln Ser Glu Leu Ser Ala Lys Met 
    50                  55                  60                  


Arg Glu Trp Phe Ser Glu Thr Phe Gln Lys Val Lys Glu Lys Leu Lys 
65                  70                  75                  80  


Ile Asp Ser 
            


<210>  2424
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  2424

Met Ser Asp Arg Pro Thr Ala Arg Arg Trp Gly Lys Cys Gly Pro Leu 
1               5                   10                  15      


Cys Thr Arg Glu Asn Ile Met Val Ala Phe Lys Gly Val Trp Thr Gln 
            20                  25                  30          


Ala Phe Trp Lys Ala Val Thr Ala Glu Phe Leu Ala Met Leu Ile Phe 
        35                  40                  45              


Val Leu Leu Ser Leu Gly Ser Thr Ile Asn Trp Gly Gly Thr Glu Lys 
    50                  55                  60                  


Pro Leu Pro Val Asp Met Val Leu Ile Ser Leu Cys Phe Gly Leu Ser 
65                  70                  75                  80  


Ile Ala Thr Met Val Gln Cys Phe Gly His Ile Ser Gly Gly His Ile 
                85                  90                  95      


Asn Pro Ala Val Thr Val Ala Met Val Cys Thr Arg Lys Ile Ser Ile 
            100                 105                 110         


Ala Lys Ser Val Phe Tyr Ile Ala Ala Gln Cys Leu Gly Ala Ile Ile 
        115                 120                 125             


Gly Ala Gly Ile Leu Tyr Leu Val Thr Pro Pro Ser Val Val Gly Gly 
    130                 135                 140                 


Leu Gly Val Thr Met Val His Gly Asn Leu Thr Ala Gly His Gly Leu 
145                 150                 155                 160 


Leu Val Glu Leu Ile Ile Thr Phe Gln Leu Val Phe Thr Ile Phe Ala 
                165                 170                 175     


Ser Cys Asp Ser Lys Arg Thr Asp Val Thr Gly Ser Ile Ala Leu Ala 
            180                 185                 190         


Ile Gly Phe Ser Val Ala Ile Gly His Leu Phe Ala Ile Asn Tyr Thr 
        195                 200                 205             


Gly Ala Ser Met Asn Pro Ala Arg Ser Phe Gly Pro Ala Val Ile Met 
    210                 215                 220                 


Gly Asn Trp Glu Asn His Trp Ile Tyr Trp Val Gly Pro Ile Ile Gly 
225                 230                 235                 240 


Ala Val Leu Ala Gly Gly Leu Tyr Glu Tyr Val Phe Cys Pro Asp Val 
                245                 250                 255     


Glu Phe Lys Arg Arg Phe Lys Glu Ala Phe Ser Lys Ala Ala Gln Gln 
            260                 265                 270         


Thr Lys Gly Ser Tyr Met Glu Val Glu Asp Asn Arg Ser Gln Val Glu 
        275                 280                 285             


Thr Asp Asp Leu Ile Leu Lys Pro Gly Val Val His Val Ile Asp Val 
    290                 295                 300                 


Asp Arg Gly Glu Glu Lys Lys Gly Lys Asp Gln Ser Gly Glu Val Leu 
305                 310                 315                 320 


Ser Ser Val 
            


<210>  2425
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  2425

Met Lys Lys Glu Val Cys Ser Val Ala Phe Leu Lys Ala Val Phe Ala 
1               5                   10                  15      


Glu Phe Leu Ala Thr Leu Ile Phe Val Phe Phe Gly Leu Gly Ser Ala 
            20                  25                  30          


Leu Lys Trp Pro Ser Ala Leu Pro Thr Ile Leu Gln Ile Ala Leu Ala 
        35                  40                  45              


Phe Gly Leu Ala Ile Gly Thr Leu Ala Gln Ala Leu Gly Pro Val Ser 
    50                  55                  60                  


Gly Gly His Ile Asn Pro Ala Ile Thr Leu Ala Leu Leu Val Gly Asn 
65                  70                  75                  80  


Gln Ile Ser Leu Leu Arg Ala Phe Phe Tyr Val Ala Ala Gln Leu Val 
                85                  90                  95      


Gly Ala Ile Ala Gly Ala Gly Ile Leu Tyr Gly Val Ala Pro Leu Asn 
            100                 105                 110         


Ala Arg Gly Asn Leu Ala Val Asn Ala Leu Asn Asn Asn Thr Thr Gln 
        115                 120                 125             


Gly Gln Ala Met Val Val Glu Leu Ile Leu Thr Phe Gln Leu Ala Leu 
    130                 135                 140                 


Cys Ile Phe Ala Ser Thr Asp Ser Arg Arg Thr Ser Pro Val Gly Ser 
145                 150                 155                 160 


Pro Ala Leu Ser Ile Gly Leu Ser Val Thr Leu Gly His Leu Val Gly 
                165                 170                 175     


Ile Tyr Phe Thr Gly Cys Ser Met Asn Pro Ala Arg Ser Phe Gly Pro 
            180                 185                 190         


Ala Val Val Met Asn Arg Phe Ser Pro Ala His Trp Val Phe Trp Val 
        195                 200                 205             


Gly Pro Ile Val Gly Ala Val Leu Ala Ala Ile Leu Tyr Phe Tyr Leu 
    210                 215                 220                 


Leu Phe Pro Asn Ser Leu Ser Leu Ser Glu Arg Val Ala Ile Ile Lys 
225                 230                 235                 240 


Gly Thr Tyr Glu Pro Asp Glu Asp Trp Glu Glu Gln Arg Glu Glu Arg 
                245                 250                 255     


Lys Lys Thr Met Glu Leu Thr Thr Arg 
            260                 265 


<210>  2426
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  2426

Met Asp Ala Val Glu Pro Gly Gly Arg Gly Trp Ala Ser Met Leu Ala 
1               5                   10                  15      


Cys Arg Leu Trp Lys Ala Ile Ser Arg Ala Leu Phe Ala Glu Phe Leu 
            20                  25                  30          


Ala Thr Gly Leu Tyr Val Phe Phe Gly Val Gly Ser Val Met Arg Trp 
        35                  40                  45              


Pro Thr Ala Leu Pro Ser Val Leu Gln Ile Ala Ile Thr Phe Asn Leu 
    50                  55                  60                  


Val Thr Ala Met Ala Val Gln Val Thr Trp Lys Ala Ser Gly Ala His 
65                  70                  75                  80  


Ala Asn Pro Ala Val Thr Leu Ala Phe Leu Val Gly Ser His Ile Ser 
                85                  90                  95      


Leu Pro Arg Ala Val Ala Tyr Val Ala Ala Gln Leu Val Gly Ala Thr 
            100                 105                 110         


Val Gly Ala Ala Leu Leu Tyr Gly Val Met Pro Gly Asp Ile Arg Glu 
        115                 120                 125             


Thr Leu Gly Ile Asn Val Val Arg Asn Ser Val Ser Thr Gly Gln Ala 
    130                 135                 140                 


Val Ala Val Glu Leu Leu Leu Thr Leu Gln Leu Val Leu Cys Val Phe 
145                 150                 155                 160 


Ala Ser Thr Asp Ser Arg Gln Thr Ser Gly Ser Pro Ala Thr Met Ile 
                165                 170                 175     


Gly Ile Ser Val Ala Leu Gly His Leu Ile Gly Ile His Phe Thr Gly 
            180                 185                 190         


Cys Ser Met Asn Pro Ala Arg Ser Phe Gly Pro Ala Ile Ile Ile Gly 
        195                 200                 205             


Lys Phe Thr Val His Trp Val Phe Trp Val Gly Pro Leu Met Gly Ala 
    210                 215                 220                 


Leu Leu Ala Ser Leu Ile Tyr Asn Phe Val Leu Phe Pro Asp Thr Lys 
225                 230                 235                 240 


Thr Leu Ala Gln Arg Leu Ala Ile Leu Thr Gly Thr Val Glu Val Gly 
                245                 250                 255     


Thr Gly Ala Gly Ala Gly Ala Glu Pro Leu Lys Lys Glu Ser Gln Pro 
            260                 265                 270         


Gly Ser Gly Ala Val Glu Met Glu Ser Val 
        275                 280         


<210>  2427
<211>  593
<212>  PRT
<213>  Homo sapiens

<400>  2427

Met Arg Ser Ala Ala Arg Arg Gly Arg Ala Ala Pro Ala Ala Arg Asp 
1               5                   10                  15      


Ser Leu Pro Val Leu Leu Phe Leu Cys Leu Leu Leu Lys Thr Cys Glu 
            20                  25                  30          


Pro Lys Thr Ala Asn Ala Phe Lys Pro Asn Ile Leu Leu Ile Met Ala 
        35                  40                  45              


Asp Asp Leu Gly Thr Gly Asp Leu Gly Cys Tyr Gly Asn Asn Thr Leu 
    50                  55                  60                  


Arg Thr Pro Asn Ile Asp Gln Leu Ala Glu Glu Gly Val Arg Leu Thr 
65                  70                  75                  80  


Gln His Leu Ala Ala Ala Pro Leu Cys Thr Pro Ser Arg Ala Ala Phe 
                85                  90                  95      


Leu Thr Gly Arg His Ser Phe Arg Ser Gly Met Asp Ala Ser Asn Gly 
            100                 105                 110         


Tyr Arg Ala Leu Gln Trp Asn Ala Gly Ser Gly Gly Leu Pro Glu Asn 
        115                 120                 125             


Glu Thr Thr Phe Ala Arg Ile Leu Gln Gln His Gly Tyr Ala Thr Gly 
    130                 135                 140                 


Leu Ile Gly Lys Trp His Gln Gly Val Asn Cys Ala Ser Arg Gly Asp 
145                 150                 155                 160 


His Cys His His Pro Leu Asn His Gly Phe Asp Tyr Phe Tyr Gly Met 
                165                 170                 175     


Pro Phe Thr Leu Thr Asn Asp Cys Asp Pro Gly Arg Pro Pro Glu Val 
            180                 185                 190         


Asp Ala Ala Leu Arg Ala Gln Leu Trp Gly Tyr Thr Gln Phe Leu Ala 
        195                 200                 205             


Leu Gly Ile Leu Thr Leu Ala Ala Gly Gln Thr Cys Gly Phe Phe Ser 
    210                 215                 220                 


Val Ser Ala Arg Ala Val Thr Gly Met Ala Gly Val Gly Cys Leu Phe 
225                 230                 235                 240 


Phe Ile Ser Trp Tyr Ser Ser Phe Gly Phe Val Arg Arg Trp Asn Cys 
                245                 250                 255     


Ile Leu Met Arg Asn His Asp Val Thr Glu Gln Pro Met Val Leu Glu 
            260                 265                 270         


Lys Thr Ala Ser Leu Met Leu Lys Glu Ala Val Ser Tyr Ile Glu Arg 
        275                 280                 285             


His Lys His Gly Pro Phe Leu Leu Phe Leu Ser Leu Leu His Val His 
    290                 295                 300                 


Ile Pro Leu Val Thr Thr Ser Ala Phe Leu Gly Lys Ser Gln His Gly 
305                 310                 315                 320 


Leu Tyr Gly Asp Asn Val Glu Glu Met Asp Trp Leu Ile Gly Lys Val 
                325                 330                 335     


Leu Asn Ala Ile Glu Asp Asn Gly Leu Lys Asn Ser Thr Phe Thr Tyr 
            340                 345                 350         


Phe Thr Ser Asp His Gly Gly His Leu Glu Ala Arg Asp Gly His Ser 
        355                 360                 365             


Gln Leu Gly Gly Trp Asn Gly Ile Tyr Lys Gly Gly Lys Gly Met Gly 
    370                 375                 380                 


Gly Trp Glu Gly Gly Ile Arg Val Pro Gly Ile Phe His Trp Pro Gly 
385                 390                 395                 400 


Val Leu Pro Ala Gly Arg Val Ile Gly Glu Pro Thr Ser Leu Met Asp 
                405                 410                 415     


Val Phe Pro Thr Val Val Gln Leu Val Gly Gly Glu Val Pro Gln Asp 
            420                 425                 430         


Arg Val Ile Asp Gly His Ser Leu Val Pro Leu Leu Gln Gly Ala Glu 
        435                 440                 445             


Ala Arg Ser Ala His Glu Phe Leu Phe His Tyr Cys Gly Gln His Leu 
    450                 455                 460                 


His Ala Ala Arg Trp His Gln Lys Asp Ser Gly Ser Val Trp Lys Val 
465                 470                 475                 480 


His Tyr Thr Thr Pro Gln Phe His Pro Glu Gly Ala Gly Ala Cys Tyr 
                485                 490                 495     


Gly Arg Gly Val Cys Pro Cys Ser Gly Glu Gly Val Thr His His Arg 
            500                 505                 510         


Pro Pro Leu Leu Phe Asp Leu Ser Arg Asp Pro Ser Glu Ala Arg Pro 
        515                 520                 525             


Leu Thr Pro Asp Ser Glu Pro Leu Tyr His Ala Val Ile Ala Arg Val 
    530                 535                 540                 


Gly Ala Ala Val Ser Glu His Arg Gln Thr Leu Ser Pro Val Pro Gln 
545                 550                 555                 560 


Gln Phe Ser Met Ser Asn Ile Leu Trp Lys Pro Trp Leu Gln Pro Cys 
                565                 570                 575     


Cys Gly His Phe Pro Phe Cys Ser Cys His Glu Asp Gly Asp Gly Thr 
            580                 585                 590         


Pro 
    


<210>  2428
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  2428

Met Thr Lys Glu Tyr Gln Asp Leu Gln His Leu Asp Asn Glu Glu Ser 
1               5                   10                  15      


Asp His His Gln Leu Arg Lys Gly Pro Pro Pro Pro Gln Pro Leu Leu 
            20                  25                  30          


Gln Arg Leu Cys Ser Gly Pro Arg Leu Leu Leu Leu Ser Leu Gly Leu 
        35                  40                  45              


Ser Leu Leu Leu Leu Val Val Val Cys Val Ile Gly Ser Gln Asn Ser 
    50                  55                  60                  


Gln Leu Gln Glu Glu Leu Arg Gly Leu Arg Glu Thr Phe Ser Asn Phe 
65                  70                  75                  80  


Thr Ala Ser Thr Glu Ala Gln Val Lys Gly Leu Ser Thr Gln Gly Gly 
                85                  90                  95      


Asn Val Gly Arg Lys Met Lys Ser Leu Glu Ser Gln Leu Glu Lys Gln 
            100                 105                 110         


Gln Lys Asp Leu Ser Glu Asp His Ser Ser Leu Leu Leu His Val Lys 
        115                 120                 125             


Gln Phe Val Ser Asp Leu Arg Ser Leu Ser Cys Gln Met Ala Ala Leu 
    130                 135                 140                 


Gln Gly Asn Gly Ser Glu Arg Thr Cys Cys Pro Val Asn Trp Val Glu 
145                 150                 155                 160 


His Glu Arg Ser Cys Tyr Trp Phe Ser Arg Ser Gly Lys Ala Trp Ala 
                165                 170                 175     


Asp Ala Asp Asn Tyr Cys Arg Leu Glu Asp Ala His Leu Val Val Val 
            180                 185                 190         


Thr Ser Trp Glu Glu Gln Lys Phe Val Gln His His Ile Gly Pro Val 
        195                 200                 205             


Asn Thr Trp Met Gly Leu His Asp Gln Asn Gly Pro Trp Lys Trp Val 
    210                 215                 220                 


Asp Gly Thr Asp Tyr Glu Thr Gly Phe Lys Asn Trp Arg Pro Glu Gln 
225                 230                 235                 240 


Pro Asp Asp Trp Tyr Gly His Gly Leu Gly Gly Gly Glu Asp Cys Ala 
                245                 250                 255     


His Phe Thr Asp Asp Gly Arg Trp Asn Asp Asp Val Cys Gln Arg Pro 
            260                 265                 270         


Tyr Arg Trp Val Cys Glu Thr Glu Leu Asp Lys Ala Ser Gln Glu Pro 
        275                 280                 285             


Pro Leu Leu 
    290     


<210>  2429
<211>  1039
<212>  PRT
<213>  Homo sapiens

<400>  2429

Met His Gln Lys Thr Pro Glu Ile Tyr Ser Val Glu Leu Ser Gly Thr 
1               5                   10                  15      


Lys Asp Ile Val Lys Thr Asp Lys Gly Asp Gly Lys Glu Lys Tyr Arg 
            20                  25                  30          


Gly Leu Lys Asn Asn Cys Leu Glu Leu Lys Lys Lys Asn His Lys Glu 
        35                  40                  45              


Glu Phe Gln Lys Glu Leu His Leu Asp Asp His Lys Leu Ser Asn Arg 
    50                  55                  60                  


Glu Leu Glu Glu Lys Tyr Gly Thr Asp Ile Ile Met Gly Leu Ser Ser 
65                  70                  75                  80  


Thr Arg Ala Ala Glu Leu Leu Ala Arg Asp Gly Pro Asn Ser Leu Thr 
                85                  90                  95      


Pro Pro Lys Gln Thr Pro Glu Ile Val Lys Phe Leu Lys Gln Met Val 
            100                 105                 110         


Gly Gly Phe Ser Ile Leu Leu Trp Val Gly Ala Phe Leu Cys Trp Ile 
        115                 120                 125             


Ala Tyr Gly Ile Gln Tyr Ser Ser Asp Lys Ser Ala Ser Leu Asn Asn 
    130                 135                 140                 


Val Tyr Leu Gly Cys Val Leu Gly Leu Val Val Ile Leu Thr Gly Ile 
145                 150                 155                 160 


Phe Ala Tyr Tyr Gln Glu Ala Lys Ser Thr Asn Ile Met Ser Ser Phe 
                165                 170                 175     


Asn Lys Met Ile Pro Gln Gln Ala Leu Val Ile Arg Asp Ser Glu Lys 
            180                 185                 190         


Lys Thr Ile Pro Ser Glu Gln Leu Val Val Gly Asp Ile Val Glu Val 
        195                 200                 205             


Lys Gly Gly Asp Gln Ile Pro Ala Asp Ile Arg Val Leu Ser Ser Gln 
    210                 215                 220                 


Gly Cys Arg Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro Gln 
225                 230                 235                 240 


Pro Arg Ser Ser Glu Phe Thr His Glu Asn Pro Leu Glu Thr Lys Asn 
                245                 250                 255     


Ile Cys Phe Tyr Ser Thr Thr Cys Leu Glu Gly Thr Val Thr Gly Met 
            260                 265                 270         


Val Ile Asn Thr Gly Asp Arg Thr Ile Ile Gly His Ile Ala Ser Leu 
        275                 280                 285             


Ala Ser Gly Val Gly Asn Glu Lys Thr Pro Ile Ala Ile Glu Ile Glu 
    290                 295                 300                 


His Phe Val His Ile Val Ala Gly Val Ala Val Ser Ile Gly Ile Leu 
305                 310                 315                 320 


Phe Phe Ile Ile Ala Val Ser Leu Lys Tyr Gln Val Leu Asp Ser Ile 
                325                 330                 335     


Ile Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu Leu 
            340                 345                 350         


Ala Thr Val Thr Val Thr Leu Ser Leu Thr Ala Lys Arg Met Ala Lys 
        355                 360                 365             


Lys Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly Ser 
    370                 375                 380                 


Thr Ser Ile Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn Arg 
385                 390                 395                 400 


Met Thr Val Ala His Leu Trp Phe Asp Asn Gln Ile Phe Val Ala Asp 
                405                 410                 415     


Thr Ser Glu Asp His Ser Asn Gln Val Phe Asp Gln Ser Ser Arg Thr 
            420                 425                 430         


Trp Ala Ser Leu Ser Lys Ile Ile Thr Leu Cys Asn Arg Ala Glu Phe 
        435                 440                 445             


Lys Pro Gly Gln Glu Asn Val Pro Ile Met Lys Lys Ala Val Ile Gly 
    450                 455                 460                 


Asp Ala Ser Glu Thr Ala Leu Leu Lys Phe Ser Glu Val Ile Leu Gly 
465                 470                 475                 480 


Asp Val Met Glu Ile Arg Lys Arg Asn Arg Lys Val Ala Glu Ile Pro 
                485                 490                 495     


Phe Asn Ser Thr Asn Lys Phe Gln Leu Ser Ile His Glu Met Asp Asp 
            500                 505                 510         


Pro His Gly Lys Arg Phe Leu Met Val Met Lys Gly Ala Pro Glu Arg 
        515                 520                 525             


Ile Leu Glu Lys Cys Ser Thr Ile Met Ile Asn Gly Glu Glu His Pro 
    530                 535                 540                 


Leu Asp Lys Ser Thr Ala Lys Thr Phe His Thr Ala Tyr Met Glu Leu 
545                 550                 555                 560 


Gly Gly Leu Gly Glu Arg Val Leu Gly Phe Cys His Leu Tyr Leu Pro 
                565                 570                 575     


Ala Asp Glu Phe Pro Glu Thr Tyr Ser Phe Asp Ile Asp Ala Met Asn 
            580                 585                 590         


Phe Pro Thr Ser Asn Leu Cys Phe Val Gly Leu Leu Ser Met Ile Asp 
        595                 600                 605             


Pro Pro Arg Ser Thr Val Pro Asp Ala Val Thr Lys Cys Arg Ser Ala 
    610                 615                 620                 


Gly Ile Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala Lys 
625                 630                 635                 640 


Ala Ile Ala Lys Ser Val Gly Ile Ile Ser Ala Asn Ser Glu Thr Val 
                645                 650                 655     


Glu Asp Ile Ala His Arg Leu Asn Ile Ala Val Glu Gln Val Asn Lys 
            660                 665                 670         


Arg Asp Ala Lys Ala Ala Val Val Thr Gly Met Glu Leu Lys Asp Met 
        675                 680                 685             


Ser Ser Glu Gln Leu Asp Glu Ile Leu Ala Asn Tyr Gln Glu Ile Val 
    690                 695                 700                 


Phe Ala Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly Cys 
705                 710                 715                 720 


Gln Arg Gln Asp Ala Val Val Ala Val Thr Gly Asp Gly Val Asn Asp 
                725                 730                 735     


Ser Pro Ala Leu Lys Lys Ala Asp Ile Gly Ile Ala Met Gly Ile Ala 
            740                 745                 750         


Gly Ser Asp Ala Ala Lys Asn Ala Ala Asp Met Val Leu Leu Asp Asp 
        755                 760                 765             


Asn Phe Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile Phe 
    770                 775                 780                 


Asp Asn Leu Lys Lys Thr Ile Ala Tyr Ser Leu Thr Lys Asn Ile Ala 
785                 790                 795                 800 


Glu Leu Cys Pro Phe Leu Ile Tyr Ile Ile Val Gly Leu Pro Leu Pro 
                805                 810                 815     


Ile Gly Thr Ile Thr Ile Leu Phe Ile Asp Leu Gly Thr Asp Ile Ile 
            820                 825                 830         


Pro Ser Ile Ala Leu Ala Tyr Glu Lys Ala Glu Ser Asp Ile Met Asn 
        835                 840                 845             


Arg Lys Pro Arg His Lys Asn Lys Asp Arg Leu Val Asn Gln Pro Leu 
    850                 855                 860                 


Ala Val Tyr Ser Tyr Leu His Ile Gly Leu Met Gln Ala Leu Gly Ala 
865                 870                 875                 880 


Phe Leu Val Tyr Phe Thr Val Tyr Ala Gln Glu Gly Phe Leu Pro Arg 
                885                 890                 895     


Thr Leu Ile Asn Leu Arg Val Glu Trp Glu Lys Asp Tyr Val Asn Asp 
            900                 905                 910         


Leu Lys Asp Ser Tyr Gly Gln Glu Trp Thr Arg Tyr Gln Arg Glu Tyr 
        915                 920                 925             


Leu Glu Trp Thr Gly Tyr Thr Ala Phe Phe Val Gly Ile Leu Val Gln 
    930                 935                 940                 


Gln Ile Ala Asp Leu Ile Ile Arg Lys Thr Arg Arg Asn Ser Ile Phe 
945                 950                 955                 960 


Gln Gln Gly Leu Phe Arg Asn Lys Val Ile Trp Val Gly Ile Thr Ser 
                965                 970                 975     


Gln Ile Ile Ile Gly Leu Ile Leu Ser Tyr Gly Leu Gly Ser Val Thr 
            980                 985                 990         


Ala Leu Ser Phe Thr Met Leu Arg  Ala Gln Tyr Trp Phe  Val Ala Val 
        995                 1000                 1005             


Pro His  Ala Ile Leu Ile Trp  Val Tyr Asp Glu Val  Arg Lys Leu 
    1010                 1015                 1020             


Phe Ile  Arg Leu Tyr Pro Gly  Ser Trp Trp Asp Lys  Asn Met Tyr 
    1025                 1030                 1035             


Tyr 
    


<210>  2430
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  2430

Met Val Ile Gln Lys Glu Lys Lys Ser Cys Gly Gln Val Val Glu Glu 
1               5                   10                  15      


Trp Lys Glu Phe Val Trp Asn Pro Arg Thr His Gln Phe Met Gly Arg 
            20                  25                  30          


Thr Gly Thr Ser Trp Ala Phe Ile Leu Leu Phe Tyr Leu Val Phe Tyr 
        35                  40                  45              


Gly Phe Leu Thr Ala Met Phe Thr Leu Thr Met Trp Val Met Leu Gln 
    50                  55                  60                  


Thr Val Ser Asp His Thr Pro Lys Tyr Gln Asp Arg Leu Ala Thr Pro 
65                  70                  75                  80  


Gly Leu Met Ile Arg Pro Lys Thr Glu Asn Leu Asp Val Ile Val Asn 
                85                  90                  95      


Val Ser Asp Thr Glu Ser Trp Asp Gln His Val Gln Lys Leu Asn Lys 
            100                 105                 110         


Phe Leu Glu Pro Tyr Asn Asp Ser Ile Gln Ala Gln Lys Asn Asp Val 
        115                 120                 125             


Cys Arg Pro Gly Arg Tyr Tyr Glu Gln Pro Asp Asn Gly Val Leu Asn 
    130                 135                 140                 


Tyr Pro Lys Arg Ala Cys Gln Phe Asn Arg Thr Gln Leu Gly Asn Cys 
145                 150                 155                 160 


Ser Gly Ile Gly Asp Ser Thr His Tyr Gly Tyr Ser Thr Gly Gln Pro 
                165                 170                 175     


Cys Val Phe Ile Lys Met Asn Arg Val Ile Asn Phe Tyr Ala Gly Ala 
            180                 185                 190         


Asn Gln Ser Met Asn Val Thr Cys Ala Gly Lys Arg Asp Glu Asp Ala 
        195                 200                 205             


Glu Asn Leu Gly Asn Phe Val Met Phe Pro Ala Asn Gly Asn Ile Asp 
    210                 215                 220                 


Leu Met Tyr Phe Pro Tyr Tyr Gly Lys Lys Phe His Val Asn Tyr Thr 
225                 230                 235                 240 


Gln Pro Leu Val Ala Val Lys Phe Leu Asn Val Thr Pro Asn Val Glu 
                245                 250                 255     


Val Asn Val Glu Cys Arg Ile Asn Ala Ala Asn Ile Ala Thr Asp Asp 
            260                 265                 270         


Glu Arg Asp Lys Phe Ala Gly Arg Val Ala Phe Lys Leu Arg Ile Asn 
        275                 280                 285             


Lys Thr 
    290 


<210>  2431
<211>  279
<212>  PRT
<213>  Homo sapiens

<400>  2431

Met Thr Lys Asn Glu Lys Lys Ser Leu Asn Gln Ser Leu Ala Glu Trp 
1               5                   10                  15      


Lys Leu Phe Ile Tyr Asn Pro Thr Thr Gly Glu Phe Leu Gly Arg Thr 
            20                  25                  30          


Ala Lys Ser Trp Gly Leu Ile Leu Leu Phe Tyr Leu Val Phe Tyr Gly 
        35                  40                  45              


Phe Leu Ala Ala Leu Phe Ser Phe Thr Met Trp Val Met Leu Gln Thr 
    50                  55                  60                  


Leu Asn Asp Glu Val Pro Lys Tyr Arg Asp Gln Ile Pro Ser Pro Gly 
65                  70                  75                  80  


Leu Met Val Phe Pro Lys Pro Val Thr Ala Leu Glu Tyr Thr Phe Ser 
                85                  90                  95      


Arg Ser Asp Pro Thr Ser Tyr Ala Gly Tyr Ile Glu Asp Leu Lys Lys 
            100                 105                 110         


Phe Leu Lys Pro Tyr Thr Leu Glu Glu Gln Lys Asn Leu Thr Val Cys 
        115                 120                 125             


Pro Asp Gly Ala Leu Phe Glu Gln Lys Gly Pro Val Tyr Val Ala Cys 
    130                 135                 140                 


Gln Phe Pro Ile Ser Leu Leu Gln Ala Cys Ser Gly Met Asn Asp Pro 
145                 150                 155                 160 


Asp Phe Gly Tyr Ser Gln Gly Asn Pro Cys Ile Leu Val Lys Met Asn 
                165                 170                 175     


Arg Ile Ile Gly Leu Lys Pro Glu Gly Val Pro Arg Ile Asp Cys Val 
            180                 185                 190         


Ser Lys Asn Glu Asp Ile Pro Asn Val Ala Val Tyr Pro His Asn Gly 
        195                 200                 205             


Met Ile Asp Leu Lys Tyr Phe Pro Tyr Tyr Gly Lys Lys Leu His Val 
    210                 215                 220                 


Gly Tyr Leu Gln Pro Leu Val Ala Val Gln Val Ser Phe Ala Pro Asn 
225                 230                 235                 240 


Asn Thr Gly Lys Glu Val Thr Val Glu Cys Lys Ile Asp Gly Ser Ala 
                245                 250                 255     


Asn Leu Lys Ser Gln Asp Asp Arg Asp Lys Phe Leu Gly Arg Val Met 
            260                 265                 270         


Phe Lys Ile Thr Ala Arg Ala 
        275                 


<210>  2432
<211>  997
<212>  PRT
<213>  Homo sapiens

<400>  2432

Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 
1               5                   10                  15      


Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
            20                  25                  30          


Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              


Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 
            180                 185                 190         


Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val 
    210                 215                 220                 


Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val 
225                 230                 235                 240 


Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
            260                 265                 270         


Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             


Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile 
        355                 360                 365             


Leu Asp Arg Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Thr Ile 
    370                 375                 380                 


Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val His Lys Asp Asp Lys 
385                 390                 395                 400 


Pro Val Asn Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys 
    450                 455                 460                 


Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe 
            500                 505                 510         


Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 
        515                 520                 525             


Val Gly Ser Thr Lys Val Pro Met Thr Ser Gly Val Lys Gln Lys Ile 
    530                 535                 540                 


Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 
545                 550                 555                 560 


Leu Ala Leu Ala Thr His Asp Asn Pro Leu Arg Arg Glu Glu Met His 
                565                 570                 575     


Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe 
            580                 585                 590         


Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser 
        595                 600                 605             


Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr 
    610                 615                 620                 


Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 
625                 630                 635                 640 


Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 
                645                 650                 655     


Phe Asp Glu Leu Asn Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 
            660                 665                 670         


Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 
        675                 680                 685             


Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val 
    690                 695                 700                 


Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly 
705                 710                 715                 720 


Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp 
                725                 730                 735     


Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 
            740                 745                 750         


Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 
        755                 760                 765             


Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 
    770                 775                 780                 


Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 
785                 790                 795                 800 


Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 
                805                 810                 815     


Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu 
            820                 825                 830         


Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val 
        835                 840                 845             


Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 
    850                 855                 860                 


Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro 
865                 870                 875                 880 


Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met 
                885                 890                 895     


Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 
            900                 905                 910         


Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 
        915                 920                 925             


Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 
    930                 935                 940                 


Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro 
945                 950                 955                 960 


Leu Asn Val Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 
                965                 970                 975     


Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 
            980                 985                 990         


Pro Ala Ile Leu Glu 
        995         


<210>  2433
<211>  1220
<212>  PRT
<213>  Homo sapiens

<400>  2433

Met Gly Asp Met Ala Asn Asn Ser Val Ala Tyr Ser Gly Val Lys Asn 
1               5                   10                  15      


Ser Leu Lys Glu Ala Asn His Asp Gly Asp Phe Gly Ile Thr Leu Ala 
            20                  25                  30          


Glu Leu Arg Ala Leu Met Glu Leu Arg Ser Thr Asp Ala Leu Arg Lys 
        35                  40                  45              


Ile Gln Glu Ser Tyr Gly Asp Val Tyr Gly Ile Cys Thr Lys Leu Lys 
    50                  55                  60                  


Thr Ser Pro Asn Glu Gly Leu Ser Gly Asn Pro Ala Asp Leu Glu Arg 
65                  70                  75                  80  


Arg Glu Ala Val Phe Gly Lys Asn Phe Ile Pro Pro Lys Lys Pro Lys 
                85                  90                  95      


Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile 
            100                 105                 110         


Ile Leu Glu Ile Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Gln 
        115                 120                 125             


Pro Pro Glu Gly Asp Asn Ala Leu Cys Gly Glu Val Ser Val Gly Glu 
    130                 135                 140                 


Glu Glu Gly Glu Gly Glu Thr Gly Trp Ile Glu Gly Ala Ala Ile Leu 
145                 150                 155                 160 


Leu Ser Val Val Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser 
                165                 170                 175     


Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu Gln 
            180                 185                 190         


Lys Phe Thr Val Ile Arg Gly Gly Gln Val Ile Gln Ile Pro Val Ala 
        195                 200                 205             


Asp Ile Thr Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu 
    210                 215                 220                 


Pro Ala Asp Gly Ile Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu 
225                 230                 235                 240 


Ser Ser Leu Thr Gly Glu Ser Asp His Val Lys Lys Ser Leu Asp Lys 
                245                 250                 255     


Asp Pro Leu Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg 
            260                 265                 270         


Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Phe 
        275                 280                 285             


Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Glu Lys 
    290                 295                 300                 


Lys Lys Glu Lys Lys Asn Lys Lys Gln Asp Gly Ala Ile Glu Asn Arg 
305                 310                 315                 320 


Asn Lys Ala Lys Ala Gln Asp Gly Ala Ala Met Glu Met Gln Pro Leu 
                325                 330                 335     


Lys Ser Glu Glu Gly Gly Asp Gly Asp Glu Lys Asp Lys Lys Lys Ala 
            340                 345                 350         


Asn Leu Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys 
        355                 360                 365             


Leu Ala Val Gln Ile Gly Lys Ala Gly Leu Leu Met Ser Ala Ile Thr 
    370                 375                 380                 


Val Ile Ile Leu Val Leu Tyr Phe Val Ile Asp Thr Phe Trp Val Gln 
385                 390                 395                 400 


Lys Arg Pro Trp Leu Ala Glu Cys Thr Pro Ile Tyr Ile Gln Tyr Phe 
                405                 410                 415     


Val Lys Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro 
            420                 425                 430         


Glu Gly Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys 
        435                 440                 445             


Lys Met Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu 
    450                 455                 460                 


Thr Met Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu 
465                 470                 475                 480 


Thr Met Asn Arg Met Thr Val Val Gln Ala Tyr Ile Asn Glu Lys His 
                485                 490                 495     


Tyr Lys Lys Val Pro Glu Pro Glu Ala Ile Pro Pro Asn Ile Leu Ser 
            500                 505                 510         


Tyr Leu Val Thr Gly Ile Ser Val Asn Cys Ala Tyr Thr Ser Lys Ile 
        515                 520                 525             


Leu Pro Pro Glu Lys Glu Gly Gly Leu Pro Arg His Val Gly Asn Lys 
    530                 535                 540                 


Thr Glu Cys Ala Leu Leu Gly Leu Leu Leu Asp Leu Lys Arg Asp Tyr 
545                 550                 555                 560 


Gln Asp Val Arg Asn Glu Ile Pro Glu Glu Ala Leu Tyr Lys Val Tyr 
                565                 570                 575     


Thr Phe Asn Ser Val Arg Lys Ser Met Ser Thr Val Leu Lys Asn Ser 
            580                 585                 590         


Asp Gly Ser Tyr Arg Ile Phe Ser Lys Gly Ala Ser Glu Ile Ile Leu 
        595                 600                 605             


Lys Lys Cys Phe Lys Ile Leu Ser Ala Asn Gly Glu Ala Lys Val Phe 
    610                 615                 620                 


Arg Pro Arg Asp Arg Asp Asp Ile Val Lys Thr Val Ile Glu Pro Met 
625                 630                 635                 640 


Ala Ser Glu Gly Leu Arg Thr Ile Cys Leu Ala Phe Arg Asp Phe Pro 
                645                 650                 655     


Ala Gly Glu Pro Glu Pro Glu Trp Asp Asn Glu Asn Asp Ile Val Thr 
            660                 665                 670         


Gly Leu Thr Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro 
        675                 680                 685             


Glu Val Pro Asp Ala Ile Lys Lys Cys Gln Arg Ala Gly Ile Thr Val 
    690                 695                 700                 


Arg Met Val Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Thr 
705                 710                 715                 720 


Lys Cys Gly Ile Leu His Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly 
                725                 730                 735     


Lys Asp Phe Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln 
            740                 745                 750         


Glu Arg Ile Asp Lys Ile Trp Pro Lys Leu Arg Val Leu Ala Arg Ser 
        755                 760                 765             


Ser Pro Thr Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr 
    770                 775                 780                 


Val Ser Asp Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn 
785                 790                 795                 800 


Asp Gly Pro Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile 
                805                 810                 815     


Ala Gly Thr Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp 
            820                 825                 830         


Asp Asn Phe Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val 
        835                 840                 845             


Tyr Asp Ser Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val 
    850                 855                 860                 


Val Ala Val Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser 
865                 870                 875                 880 


Pro Leu Lys Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr 
                885                 890                 895     


Leu Ala Ser Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu 
            900                 905                 910         


Leu Arg Lys Pro Tyr Gly Arg Asn Lys Pro Leu Ile Ser Arg Thr Met 
        915                 920                 925             


Met Lys Asn Ile Leu Gly His Ala Phe Tyr Gln Leu Val Val Val Phe 
    930                 935                 940                 


Thr Leu Leu Phe Ala Gly Glu Lys Phe Phe Asp Ile Asp Ser Gly Arg 
945                 950                 955                 960 


Asn Ala Pro Leu His Ala Pro Pro Ser Glu His Tyr Thr Ile Val Phe 
                965                 970                 975     


Asn Thr Phe Val Leu Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys 
            980                 985                 990         


Ile His Gly Glu Arg Asn Val Phe  Glu Gly Ile Phe Asn  Asn Ala Ile 
        995                 1000                 1005             


Phe Cys  Thr Ile Val Leu Gly  Thr Phe Val Val Gln  Ile Ile Ile 
    1010                 1015                 1020             


Val Gln  Phe Gly Gly Lys Pro  Phe Ser Cys Ser Glu  Leu Ser Ile 
    1025                 1030                 1035             


Glu Gln  Trp Leu Trp Ser Ile  Phe Leu Gly Met Gly  Thr Leu Leu 
    1040                 1045                 1050             


Trp Gly  Gln Leu Ile Ser Thr  Ile Pro Thr Ser Arg  Leu Lys Phe 
    1055                 1060                 1065             


Leu Lys  Glu Ala Gly His Gly  Thr Gln Lys Glu Glu  Ile Pro Glu 
    1070                 1075                 1080             


Glu Glu  Leu Ala Glu Asp Val  Glu Glu Ile Asp His  Ala Glu Arg 
    1085                 1090                 1095             


Glu Leu  Arg Arg Gly Gln Ile  Leu Trp Phe Arg Gly  Leu Asn Arg 
    1100                 1105                 1110             


Ile Gln  Thr Gln Ile Arg Val  Val Asn Ala Phe Arg  Ser Ser Leu 
    1115                 1120                 1125             


Tyr Glu  Gly Leu Glu Lys Pro  Glu Ser Arg Ser Ser  Ile His Asn 
    1130                 1135                 1140             


Phe Met  Thr His Pro Glu Phe  Arg Ile Glu Asp Ser  Glu Pro His 
    1145                 1150                 1155             


Ile Pro  Leu Ile Asp Asp Thr  Asp Ala Glu Asp Asp  Ala Pro Thr 
    1160                 1165                 1170             


Lys Arg  Asn Ser Ser Pro Pro  Pro Ser Pro Asn Lys  Asn Asn Asn 
    1175                 1180                 1185             


Ala Val  Asp Ser Gly Ile His  Leu Thr Ile Glu Met  Asn Lys Ser 
    1190                 1195                 1200             


Ala Thr  Ser Ser Ser Pro Gly  Ser Pro Leu His Ser  Leu Glu Thr 
    1205                 1210                 1215             


Ser Leu  
    1220 


<210>  2434
<211>  1198
<212>  PRT
<213>  Homo sapiens

<400>  2434

Met Gly Asp Met Thr Asn Ser Asp Phe Tyr Ser Lys Asn Gln Arg Asn 
1               5                   10                  15      


Glu Ser Ser His Gly Gly Glu Phe Gly Cys Thr Met Glu Glu Leu Arg 
            20                  25                  30          


Ser Leu Met Glu Leu Arg Gly Thr Glu Ala Val Val Lys Ile Lys Glu 
        35                  40                  45              


Thr Tyr Gly Asp Thr Glu Ala Ile Cys Arg Arg Leu Lys Thr Ser Pro 
    50                  55                  60                  


Val Glu Gly Leu Pro Gly Thr Ala Pro Asp Leu Glu Lys Arg Lys Gln 
65                  70                  75                  80  


Ile Phe Gly Gln Asn Phe Ile Pro Pro Lys Lys Pro Lys Thr Phe Leu 
                85                  90                  95      


Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile Ile Leu Glu 
            100                 105                 110         


Ile Ala Ala Ile Ile Ser Leu Gly Leu Ser Phe Tyr His Pro Pro Gly 
        115                 120                 125             


Glu Gly Asn Glu Gly Cys Ala Thr Ala Gln Gly Gly Ala Glu Asp Glu 
    130                 135                 140                 


Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile Leu Leu Ser 
145                 150                 155                 160 


Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser Lys Glu 
                165                 170                 175     


Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu Gln Lys Phe 
            180                 185                 190         


Thr Val Val Arg Ala Gly Gln Val Val Gln Ile Pro Val Ala Glu Ile 
        195                 200                 205             


Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu Pro Ala 
    210                 215                 220                 


Asp Gly Leu Phe Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu Ser Ser 
225                 230                 235                 240 


Leu Thr Gly Glu Ser Asp Gln Val Arg Lys Ser Val Asp Lys Asp Pro 
                245                 250                 255     


Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg Met Leu 
            260                 265                 270         


Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Phe Thr Leu 
        275                 280                 285             


Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys Lys Ala Lys 
    290                 295                 300                 


Gln Gln Asp Gly Ala Ala Ala Met Glu Met Gln Pro Leu Lys Ser Ala 
305                 310                 315                 320 


Glu Gly Gly Asp Ala Asp Asp Arg Lys Lys Ala Ser Met His Lys Lys 
                325                 330                 335     


Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys Leu Ala Val Gln Ile 
            340                 345                 350         


Gly Lys Ala Gly Leu Val Met Ser Ala Ile Thr Val Ile Ile Leu Val 
        355                 360                 365             


Leu Tyr Phe Thr Val Asp Thr Phe Val Val Asn Lys Lys Pro Trp Leu 
    370                 375                 380                 


Pro Glu Cys Thr Pro Val Tyr Val Gln Tyr Phe Val Lys Phe Phe Ile 
385                 390                 395                 400 


Ile Gly Val Thr Val Leu Val Val Ala Val Pro Glu Gly Leu Pro Leu 
                405                 410                 415     


Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys Lys Met Met Lys Asp 
            420                 425                 430         


Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu Thr Met Gly Asn Ala 
        435                 440                 445             


Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr Asn Arg Met 
    450                 455                 460                 


Thr Val Val Gln Ala Tyr Val Gly Asp Val His Tyr Lys Glu Ile Pro 
465                 470                 475                 480 


Asp Pro Ser Ser Ile Asn Thr Lys Thr Met Glu Leu Leu Ile Asn Ala 
                485                 490                 495     


Ile Ala Ile Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro Pro Glu Lys 
            500                 505                 510         


Glu Gly Ala Leu Pro Arg Gln Val Gly Asn Lys Thr Glu Cys Gly Leu 
        515                 520                 525             


Leu Gly Phe Val Leu Asp Leu Lys Gln Asp Tyr Glu Pro Val Arg Ser 
    530                 535                 540                 


Gln Met Pro Glu Glu Lys Leu Tyr Lys Val Tyr Thr Phe Asn Ser Val 
545                 550                 555                 560 


Arg Lys Ser Met Ser Thr Val Ile Lys Leu Pro Asp Glu Ser Phe Arg 
                565                 570                 575     


Met Tyr Ser Lys Gly Ala Ser Glu Ile Val Leu Lys Lys Cys Cys Lys 
            580                 585                 590         


Ile Leu Asn Gly Ala Gly Glu Pro Arg Val Phe Arg Pro Arg Asp Arg 
        595                 600                 605             


Asp Glu Met Val Lys Lys Val Ile Glu Pro Met Ala Cys Asp Gly Leu 
    610                 615                 620                 


Arg Thr Ile Cys Val Ala Tyr Arg Asp Phe Pro Ser Ser Pro Glu Pro 
625                 630                 635                 640 


Asp Trp Asp Asn Glu Asn Asp Ile Leu Asn Glu Leu Thr Cys Ile Cys 
                645                 650                 655     


Val Val Gly Ile Glu Asp Pro Val Arg Pro Glu Val Pro Glu Ala Ile 
            660                 665                 670         


Arg Lys Cys Gln Arg Ala Gly Ile Thr Val Arg Met Val Thr Gly Asp 
        675                 680                 685             


Asn Ile Asn Thr Ala Arg Ala Ile Ala Ile Lys Cys Gly Ile Ile His 
    690                 695                 700                 


Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe Asn Arg Arg 
705                 710                 715                 720 


Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln Glu Arg Ile Asp Lys Ile 
                725                 730                 735     


Trp Pro Lys Leu Arg Val Leu Ala Arg Ser Ser Pro Thr Asp Lys His 
            740                 745                 750         


Thr Leu Val Lys Gly Ile Ile Asp Ser Thr His Thr Glu Gln Arg Gln 
        755                 760                 765             


Val Val Ala Val Thr Gly Asp Gly Thr Asn Asp Gly Pro Ala Leu Lys 
    770                 775                 780                 


Lys Ala Asp Val Gly Phe Ala Met Gly Ile Ala Gly Thr Asp Val Ala 
785                 790                 795                 800 


Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe Ser Ser Ile 
                805                 810                 815     


Val Lys Ala Val Met Trp Gly Arg Asn Val Tyr Asp Ser Ile Ser Lys 
            820                 825                 830         


Phe Leu Gln Phe Gln Leu Thr Val Asn Val Val Ala Val Ile Val Ala 
        835                 840                 845             


Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys Ala Val Gln 
    850                 855                 860                 


Met Leu Trp Val Asn Leu Ile Met Asp Thr Phe Ala Ser Leu Ala Leu 
865                 870                 875                 880 


Ala Thr Glu Pro Pro Thr Glu Thr Leu Leu Leu Arg Lys Pro Tyr Gly 
                885                 890                 895     


Arg Asn Lys Pro Leu Ile Ser Arg Thr Met Met Lys Asn Ile Leu Gly 
            900                 905                 910         


His Ala Val Tyr Gln Leu Ala Leu Ile Phe Thr Leu Leu Phe Val Gly 
        915                 920                 925             


Glu Lys Met Phe Gln Ile Asp Ser Gly Arg Asn Ala Pro Leu His Ser 
    930                 935                 940                 


Pro Pro Ser Glu His Tyr Thr Ile Ile Phe Asn Thr Phe Val Met Met 
945                 950                 955                 960 


Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys Ile His Gly Glu Arg Asn 
                965                 970                 975     


Val Phe Asp Gly Ile Phe Arg Asn Pro Ile Phe Cys Thr Ile Val Leu 
            980                 985                 990         


Gly Thr Phe Ala Ile Gln Ile Val  Ile Val Gln Phe Gly  Gly Lys Pro 
        995                 1000                 1005             


Phe Ser  Cys Ser Pro Leu Gln  Leu Asp Gln Trp Met  Trp Cys Ile 
    1010                 1015                 1020             


Phe Ile  Gly Leu Gly Glu Leu  Val Trp Gly Gln Val  Ile Ala Thr 
    1025                 1030                 1035             


Ile Pro  Thr Ser Arg Leu Lys  Phe Leu Lys Glu Ala  Gly Arg Leu 
    1040                 1045                 1050             


Thr Gln  Lys Glu Glu Ile Pro  Glu Glu Glu Leu Asn  Glu Asp Val 
    1055                 1060                 1065             


Glu Glu  Ile Asp His Ala Glu  Arg Glu Leu Arg Arg  Gly Gln Ile 
    1070                 1075                 1080             


Leu Trp  Phe Arg Gly Leu Asn  Arg Ile Gln Thr Gln  Ile Arg Val 
    1085                 1090                 1095             


Val Lys  Ala Phe Arg Ser Ser  Leu Tyr Glu Gly Leu  Glu Lys Pro 
    1100                 1105                 1110             


Glu Ser  Arg Thr Ser Ile His  Asn Phe Met Ala His  Pro Glu Phe 
    1115                 1120                 1125             


Arg Ile  Glu Asp Ser Gln Pro  His Ile Pro Leu Ile  Asp Asp Thr 
    1130                 1135                 1140             


Asp Leu  Glu Glu Asp Ala Ala  Leu Lys Gln Asn Ser  Ser Pro Pro 
    1145                 1150                 1155             


Ser Ser  Leu Asn Lys Asn Asn  Ser Ala Ile Asp Ser  Gly Ile Asn 
    1160                 1165                 1170             


Leu Thr  Thr Asp Thr Ser Lys  Ser Ala Thr Ser Ser  Ser Pro Gly 
    1175                 1180                 1185             


Ser Pro  Ile His Ser Leu Glu  Thr Ser Leu 
    1190                 1195             


<210>  2435
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  2435

Met Leu Ser Arg Val Val Leu Ser Ala Ala Ala Thr Ala Ala Pro Ser 
1               5                   10                  15      


Leu Lys Asn Ala Ala Phe Leu Gly Pro Gly Val Leu Gln Ala Thr Arg 
            20                  25                  30          


Thr Phe His Thr Gly Gln Pro His Leu Val Pro Val Pro Pro Leu Pro 
        35                  40                  45              


Glu Tyr Gly Gly Lys Val Arg Tyr Gly Leu Ile Pro Glu Glu Phe Phe 
    50                  55                  60                  


Gln Phe Leu Tyr Pro Lys Thr Gly Val Thr Gly Pro Tyr Val Leu Gly 
65                  70                  75                  80  


Thr Gly Leu Ile Leu Tyr Ala Leu Ser Lys Glu Ile Tyr Val Ile Ser 
                85                  90                  95      


Ala Glu Thr Phe Thr Ala Leu Ser Val Leu Gly Val Met Val Tyr Gly 
            100                 105                 110         


Ile Lys Lys Tyr Gly Pro Phe Val Ala Asp Phe Ala Asp Lys Leu Asn 
        115                 120                 125             


Glu Gln Lys Leu Ala Gln Leu Glu Glu Ala Lys Gln Ala Ser Ile Gln 
    130                 135                 140                 


His Ile Gln Asn Ala Ile Asp Thr Glu Lys Ser Gln Gln Ala Leu Val 
145                 150                 155                 160 


Gln Lys Arg His Tyr Leu Phe Asp Val Gln Arg Asn Asn Ile Ala Met 
                165                 170                 175     


Ala Leu Glu Val Thr Tyr Arg Glu Arg Leu Tyr Arg Val Tyr Lys Glu 
            180                 185                 190         


Val Lys Asn Arg Leu Asp Tyr His Ile Ser Val Gln Asn Met Met Arg 
        195                 200                 205             


Arg Lys Glu Gln Glu His Met Ile Asn Trp Val Glu Lys His Val Val 
    210                 215                 220                 


Gln Ser Ile Ser Thr Gln Gln Glu Lys Glu Thr Ile Ala Lys Cys Ile 
225                 230                 235                 240 


Ala Asp Leu Lys Leu Leu Ala Lys Lys Ala Gln Ala Gln Pro Val Met 
                245                 250                 255     


<210>  2436
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  2436

Met Phe Ala Cys Ala Lys Leu Ala Cys Thr Pro Ser Leu Ile Arg Ala 
1               5                   10                  15      


Gly Ser Arg Val Ala Tyr Arg Pro Ile Ser Ala Ser Val Leu Ser Arg 
            20                  25                  30          


Pro Glu Ala Ser Arg Thr Gly Glu Gly Ser Thr Val Phe Asn Gly Ala 
        35                  40                  45              


Gln Asn Gly Val Ser Gln Leu Ile Gln Arg Glu Phe Gln Thr Ser Ala 
    50                  55                  60                  


Ile Ser Arg Asp Ile Asp Thr Ala Ala Lys Phe Ile Gly Ala Gly Ala 
65                  70                  75                  80  


Ala Thr Val Gly Val Ala Gly Ser Gly Ala Gly Ile Gly Thr Val Phe 
                85                  90                  95      


Gly Ser Leu Ile Ile Gly Tyr Ala Arg Asn Pro Ser Leu Lys Gln Gln 
            100                 105                 110         


Leu Phe Ser Tyr Ala Ile Leu Gly Phe Ala Leu Ser Glu Ala Met Gly 
        115                 120                 125             


Leu Phe Cys Leu Met Val Ala Phe Leu Ile Leu Phe Ala Met 
    130                 135                 140         


<210>  2437
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  2437

Met Ser Glu Ser Lys Ser Gly Pro Glu Tyr Ala Ser Phe Phe Ala Val 
1               5                   10                  15      


Met Gly Ala Ser Ala Ala Met Val Phe Ser Ala Leu Gly Ala Ala Tyr 
            20                  25                  30          


Gly Thr Ala Lys Ser Gly Thr Gly Ile Ala Ala Met Ser Val Met Arg 
        35                  40                  45              


Pro Glu Gln Ile Met Lys Ser Ile Ile Pro Val Val Met Ala Gly Ile 
    50                  55                  60                  


Ile Ala Ile Tyr Gly Leu Val Val Ala Val Leu Ile Ala Asn Ser Leu 
65                  70                  75                  80  


Asn Asp Asp Ile Ser Leu Tyr Lys Ser Phe Leu Gln Leu Gly Ala Gly 
                85                  90                  95      


Leu Ser Val Gly Leu Ser Gly Leu Ala Ala Gly Phe Ala Ile Gly Ile 
            100                 105                 110         


Val Gly Asp Ala Gly Val Arg Gly Thr Ala Gln Gln Pro Arg Leu Phe 
        115                 120                 125             


Val Gly Met Ile Leu Ile Leu Ile Phe Ala Glu Val Leu Gly Leu Tyr 
    130                 135                 140                 


Gly Leu Ile Val Ala Leu Ile Leu Ser Thr Lys 
145                 150                 155 


<210>  2438
<211>  885
<212>  PRT
<213>  Homo sapiens

<400>  2438

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Val Lys Glu Pro 
            420                 425                 430         


Ser Thr Pro Ala Phe Ser Trp Pro Trp Trp Tyr Val Leu Leu Gly Ala 
        435                 440                 445             


Val Val Ala Ala Ala Cys Val Leu Ile Leu Ala Leu Phe Leu Val His 
    450                 455                 460                 


Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu Pro Thr Val 
465                 470                 475                 480 


Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser Tyr Ser 
                485                 490                 495     


Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile Ser Glu Glu 
            500                 505                 510         


Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg His Lys Val Ala 
        515                 520                 525             


Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Ala Val Met Glu Gly 
    530                 535                 540                 


Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys Thr Met 
545                 550                 555                 560 


Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe Leu Ser Glu 
                565                 570                 575     


Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val Met Arg Leu Ile 
            580                 585                 590         


Gly Val Cys Phe Gln Gly Ser Glu Arg Glu Ser Phe Pro Ala Pro Val 
        595                 600                 605             


Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ser Phe Leu Leu 
    610                 615                 620                 


Tyr Ser Arg Leu Gly Asp Gln Pro Val Tyr Leu Pro Thr Gln Met Leu 
625                 630                 635                 640 


Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu Ser Thr 
                645                 650                 655     


Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asn 
            660                 665                 670         


Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile 
        675                 680                 685             


Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val 
    690                 695                 700                 


Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys 
705                 710                 715                 720 


Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg 
                725                 730                 735     


Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr Asp Tyr 
            740                 745                 750         


Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro Ala Asp Cys Leu Asp Gly 
        755                 760                 765             


Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Gln Asp Arg 
    770                 775                 780                 


Pro Ser Phe Thr Glu Leu Arg Glu Asp Leu Glu Asn Thr Leu Lys Ala 
785                 790                 795                 800 


Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val Asn Met Asp 
                805                 810                 815     


Glu Gly Gly Gly Tyr Pro Glu Pro Pro Gly Ala Ala Gly Gly Ala Asp 
            820                 825                 830         


Pro Pro Thr Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys Leu Thr Ala 
        835                 840                 845             


Ala Glu Val His Pro Ala Gly Arg Tyr Val Leu Cys Pro Ser Thr Thr 
    850                 855                 860                 


Pro Ser Pro Ala Gln Pro Ala Asp Arg Gly Ser Pro Ala Ala Pro Gly 
865                 870                 875                 880 


Gln Glu Asp Gly Ala 
                885 


<210>  2439
<211>  1584
<212>  PRT
<213>  Homo sapiens

<400>  2439

Met Arg Gly Gln Ala Ala Ala Pro Gly Pro Val Trp Ile Leu Ala Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Gly Arg Arg Ala Arg Ala Ala Ala 
            20                  25                  30          


Gly Ala Asp Ala Gly Pro Gly Pro Glu Pro Cys Ala Thr Leu Val Gln 
        35                  40                  45              


Gly Lys Phe Phe Gly Tyr Phe Ser Ala Ala Ala Val Phe Pro Ala Asn 
    50                  55                  60                  


Ala Ser Arg Cys Ser Trp Thr Leu Arg Asn Pro Asp Pro Arg Arg Tyr 
65                  70                  75                  80  


Thr Leu Tyr Met Lys Val Ala Lys Ala Pro Val Pro Cys Ser Gly Pro 
                85                  90                  95      


Gly Arg Val Arg Thr Tyr Gln Phe Asp Ser Phe Leu Glu Ser Thr Arg 
            100                 105                 110         


Thr Tyr Leu Gly Val Glu Ser Phe Asp Glu Val Leu Arg Leu Cys Asp 
        115                 120                 125             


Pro Ser Ala Pro Leu Ala Phe Leu Gln Ala Ser Lys Gln Phe Leu Gln 
    130                 135                 140                 


Met Arg Arg Gln Gln Pro Pro Gln His Asp Gly Leu Arg Pro Arg Ala 
145                 150                 155                 160 


Gly Pro Pro Gly Pro Thr Asp Asp Phe Ser Val Glu Tyr Leu Val Val 
                165                 170                 175     


Gly Asn Arg Asn Pro Ser Arg Ala Ala Cys Gln Met Leu Cys Arg Trp 
            180                 185                 190         


Leu Asp Ala Cys Leu Ala Gly Ser Arg Ser Ser His Pro Cys Gly Ile 
        195                 200                 205             


Met Gln Thr Pro Cys Ala Cys Leu Gly Gly Glu Ala Gly Gly Pro Ala 
    210                 215                 220                 


Ala Gly Pro Leu Ala Pro Arg Gly Asp Val Cys Leu Arg Asp Ala Val 
225                 230                 235                 240 


Ala Gly Gly Pro Glu Asn Cys Leu Thr Ser Leu Thr Gln Asp Arg Gly 
                245                 250                 255     


Gly His Gly Ala Thr Gly Gly Trp Lys Leu Trp Ser Leu Trp Gly Glu 
            260                 265                 270         


Cys Thr Arg Asp Cys Gly Gly Gly Leu Gln Thr Arg Thr Arg Thr Cys 
        275                 280                 285             


Leu Pro Ala Pro Gly Val Glu Gly Gly Gly Cys Glu Gly Val Leu Glu 
    290                 295                 300                 


Glu Gly Arg Gln Cys Asn Arg Glu Ala Cys Gly Pro Ala Gly Arg Thr 
305                 310                 315                 320 


Ser Ser Arg Ser Gln Ser Leu Arg Ser Thr Asp Ala Arg Arg Arg Glu 
                325                 330                 335     


Glu Leu Gly Asp Glu Leu Gln Gln Phe Gly Phe Pro Ala Pro Gln Thr 
            340                 345                 350         


Gly Asp Pro Ala Ala Glu Glu Trp Ser Pro Trp Ser Val Cys Ser Ser 
        355                 360                 365             


Thr Cys Gly Glu Gly Trp Gln Thr Arg Thr Arg Phe Cys Val Ser Ser 
    370                 375                 380                 


Ser Tyr Ser Thr Gln Cys Ser Gly Pro Leu Arg Glu Gln Arg Leu Cys 
385                 390                 395                 400 


Asn Asn Ser Ala Val Cys Pro Val His Gly Ala Trp Asp Glu Trp Ser 
                405                 410                 415     


Pro Trp Ser Leu Cys Ser Ser Thr Cys Gly Arg Gly Phe Arg Asp Arg 
            420                 425                 430         


Thr Arg Thr Cys Arg Pro Pro Gln Phe Gly Gly Asn Pro Cys Glu Gly 
        435                 440                 445             


Pro Glu Lys Gln Thr Lys Phe Cys Asn Ile Ala Leu Cys Pro Gly Arg 
    450                 455                 460                 


Ala Val Asp Gly Asn Trp Asn Glu Trp Ser Ser Trp Ser Ala Cys Ser 
465                 470                 475                 480 


Ala Ser Cys Ser Gln Gly Arg Gln Gln Arg Thr Arg Glu Cys Asn Gly 
                485                 490                 495     


Pro Ser Tyr Gly Gly Ala Glu Cys Gln Gly His Trp Val Glu Thr Arg 
            500                 505                 510         


Asp Cys Phe Leu Gln Gln Cys Pro Val Asp Gly Lys Trp Gln Ala Trp 
        515                 520                 525             


Ala Ser Trp Gly Ser Cys Ser Val Thr Cys Gly Ala Gly Ser Gln Arg 
    530                 535                 540                 


Arg Glu Arg Val Cys Ser Gly Pro Phe Phe Gly Gly Ala Ala Cys Gln 
545                 550                 555                 560 


Gly Pro Gln Asp Glu Tyr Arg Gln Cys Gly Thr Gln Arg Cys Pro Glu 
                565                 570                 575     


Pro His Glu Ile Cys Asp Glu Asp Asn Phe Gly Ala Val Ile Trp Lys 
            580                 585                 590         


Glu Thr Pro Ala Gly Glu Val Ala Ala Val Arg Cys Pro Arg Asn Ala 
        595                 600                 605             


Thr Gly Leu Ile Leu Arg Arg Cys Glu Leu Asp Glu Glu Gly Ile Ala 
    610                 615                 620                 


Tyr Trp Glu Pro Pro Thr Tyr Ile Arg Cys Val Ser Ile Asp Tyr Arg 
625                 630                 635                 640 


Asn Ile Gln Met Met Thr Arg Glu His Leu Ala Lys Ala Gln Arg Gly 
                645                 650                 655     


Leu Pro Gly Glu Gly Val Ser Glu Val Ile Gln Thr Leu Val Glu Ile 
            660                 665                 670         


Ser Gln Asp Gly Thr Ser Tyr Ser Gly Asp Leu Leu Ser Thr Ile Asp 
        675                 680                 685             


Val Leu Arg Asn Met Thr Glu Ile Phe Arg Arg Ala Tyr Tyr Ser Pro 
    690                 695                 700                 


Thr Pro Gly Asp Val Gln Asn Phe Val Gln Ile Leu Ser Asn Leu Leu 
705                 710                 715                 720 


Ala Glu Glu Asn Arg Asp Lys Trp Glu Glu Ala Gln Leu Ala Gly Pro 
                725                 730                 735     


Asn Ala Lys Glu Leu Phe Arg Leu Val Glu Asp Phe Val Asp Val Ile 
            740                 745                 750         


Gly Phe Arg Met Lys Asp Leu Arg Asp Ala Tyr Gln Val Thr Asp Asn 
        755                 760                 765             


Leu Val Leu Ser Ile His Lys Leu Pro Ala Ser Gly Ala Thr Asp Ile 
    770                 775                 780                 


Ser Phe Pro Met Lys Gly Trp Arg Ala Thr Gly Asp Trp Ala Lys Val 
785                 790                 795                 800 


Pro Glu Asp Arg Val Thr Val Ser Lys Ser Val Phe Ser Thr Gly Leu 
                805                 810                 815     


Thr Glu Ala Asp Glu Ala Ser Val Phe Val Val Gly Thr Val Leu Tyr 
            820                 825                 830         


Arg Asn Leu Gly Ser Phe Leu Ala Leu Gln Arg Asn Thr Thr Val Leu 
        835                 840                 845             


Asn Ser Lys Val Ile Ser Val Thr Val Lys Pro Pro Pro Arg Ser Leu 
    850                 855                 860                 


Arg Thr Pro Leu Glu Ile Glu Phe Ala His Met Tyr Asn Gly Thr Thr 
865                 870                 875                 880 


Asn Gln Thr Cys Ile Leu Trp Asp Glu Thr Asp Val Pro Ser Ser Ser 
                885                 890                 895     


Ala Pro Pro Gln Leu Gly Pro Trp Ser Trp Arg Gly Cys Arg Thr Val 
            900                 905                 910         


Pro Leu Asp Ala Leu Arg Thr Arg Cys Leu Cys Asp Arg Leu Ser Thr 
        915                 920                 925             


Phe Ala Ile Leu Ala Gln Leu Ser Ala Asp Ala Asn Met Glu Lys Ala 
    930                 935                 940                 


Thr Leu Pro Ser Val Thr Leu Ile Val Gly Cys Gly Val Ser Ser Leu 
945                 950                 955                 960 


Thr Leu Leu Met Leu Val Ile Ile Tyr Val Ser Val Trp Arg Tyr Ile 
                965                 970                 975     


Arg Ser Glu Arg Ser Val Ile Leu Ile Asn Phe Cys Leu Ser Ile Ile 
            980                 985                 990         


Ser Ser Asn Ala Leu Ile Leu Ile  Gly Gln Thr Gln Thr  Arg Asn Lys 
        995                 1000                 1005             


Val Val  Cys Thr Leu Val Ala  Ala Phe Leu His Phe  Phe Phe Leu 
    1010                 1015                 1020             


Ser Ser  Phe Cys Trp Val Leu  Thr Glu Ala Trp Gln  Ser Tyr Met 
    1025                 1030                 1035             


Ala Val  Thr Gly His Leu Arg  Asn Arg Leu Ile Arg  Lys Arg Phe 
    1040                 1045                 1050             


Leu Cys  Leu Gly Trp Gly Leu  Pro Ala Leu Val Val  Ala Ile Ser 
    1055                 1060                 1065             


Val Gly  Phe Thr Lys Ala Lys  Gly Tyr Ser Thr Met  Asn Tyr Cys 
    1070                 1075                 1080             


Trp Leu  Ser Leu Glu Gly Gly  Leu Leu Tyr Ala Phe  Val Gly Pro 
    1085                 1090                 1095             


Ala Ala  Ala Val Val Leu Val  Asn Met Val Ile Gly  Ile Leu Val 
    1100                 1105                 1110             


Phe Asn  Lys Leu Val Ser Lys  Asp Gly Ile Thr Asp  Lys Lys Leu 
    1115                 1120                 1125             


Lys Glu  Arg Ala Gly Ala Ser  Leu Trp Ser Ser Cys  Val Val Leu 
    1130                 1135                 1140             


Pro Leu  Leu Ala Leu Thr Trp  Met Ser Ala Val Leu  Ala Val Thr 
    1145                 1150                 1155             


Asp Arg  Arg Ser Ala Leu Phe  Gln Ile Leu Phe Ala  Val Phe Asp 
    1160                 1165                 1170             


Ser Leu  Glu Gly Phe Val Ile  Val Met Val His Cys  Ile Leu Arg 
    1175                 1180                 1185             


Arg Glu  Val Gln Asp Ala Val  Lys Cys Arg Val Val  Asp Arg Gln 
    1190                 1195                 1200             


Glu Glu  Gly Asn Gly Asp Ser  Gly Gly Ser Phe Gln  Asn Gly His 
    1205                 1210                 1215             


Ala Gln  Leu Met Thr Asp Phe  Glu Lys Asp Val Asp  Leu Ala Cys 
    1220                 1225                 1230             


Arg Ser  Val Leu Asn Lys Asp  Ile Ala Ala Cys Arg  Thr Ala Thr 
    1235                 1240                 1245             


Ile Thr  Gly Thr Leu Lys Arg  Pro Ser Leu Pro Glu  Glu Glu Lys 
    1250                 1255                 1260             


Leu Lys  Leu Ala His Ala Lys  Gly Pro Pro Thr Asn  Phe Asn Ser 
    1265                 1270                 1275             


Leu Pro  Ala Asn Val Ser Lys  Leu His Leu His Gly  Ser Pro Arg 
    1280                 1285                 1290             


Tyr Pro  Gly Gly Pro Leu Pro  Asp Phe Pro Asn His  Ser Leu Thr 
    1295                 1300                 1305             


Leu Lys  Arg Asp Lys Ala Pro  Lys Ser Ser Phe Val  Gly Asp Gly 
    1310                 1315                 1320             


Asp Ile  Phe Lys Lys Leu Asp  Ser Glu Leu Ser Arg  Ala Gln Glu 
    1325                 1330                 1335             


Lys Ala  Leu Asp Thr Ser Tyr  Val Ile Leu Pro Thr  Ala Thr Ala 
    1340                 1345                 1350             


Thr Leu  Arg Pro Lys Pro Lys  Glu Glu Pro Lys Tyr  Ser Ile His 
    1355                 1360                 1365             


Ile Asp  Gln Met Pro Gln Thr  Arg Leu Ile His Leu  Ser Thr Ala 
    1370                 1375                 1380             


Pro Glu  Ala Ser Leu Pro Ala  Arg Ser Pro Pro Ser  Arg Gln Pro 
    1385                 1390                 1395             


Pro Ser  Gly Gly Pro Pro Glu  Ala Pro Pro Ala Gln  Pro Pro Pro 
    1400                 1405                 1410             


Pro Pro  Pro Pro Pro Pro Pro  Pro Pro Gln Gln Pro  Leu Pro Pro 
    1415                 1420                 1425             


Pro Pro  Asn Leu Glu Pro Ala  Pro Pro Ser Leu Gly  Asp Pro Gly 
    1430                 1435                 1440             


Glu Pro  Ala Ala His Pro Gly  Pro Ser Thr Gly Pro  Ser Thr Lys 
    1445                 1450                 1455             


Asn Glu  Asn Val Ala Thr Leu  Ser Val Ser Ser Leu  Glu Arg Arg 
    1460                 1465                 1470             


Lys Ser  Arg Tyr Ala Glu Leu  Asp Phe Glu Lys Ile  Met His Thr 
    1475                 1480                 1485             


Arg Lys  Arg His Gln Asp Met  Phe Gln Asp Leu Asn  Arg Lys Leu 
    1490                 1495                 1500             


Gln His  Ala Ala Glu Lys Asp  Lys Glu Val Leu Gly  Pro Asp Ser 
    1505                 1510                 1515             


Lys Pro  Glu Lys Gln Gln Thr  Pro Asn Lys Arg Pro  Trp Glu Ser 
    1520                 1525                 1530             


Leu Arg  Lys Ala His Gly Thr  Pro Thr Trp Val Lys  Lys Glu Leu 
    1535                 1540                 1545             


Glu Pro  Leu Gln Pro Ser Pro  Leu Glu Leu Arg Ser  Val Glu Trp 
    1550                 1555                 1560             


Glu Arg  Ser Gly Ala Thr Ile  Pro Leu Val Gly Gln  Asp Ile Ile 
    1565                 1570                 1575             


Asp Leu  Gln Thr Glu Val 
    1580                 


<210>  2440
<211>  1522
<212>  PRT
<213>  Homo sapiens

<400>  2440

Met Lys Ala Val Arg Asn Leu Leu Ile Tyr Ile Phe Ser Thr Tyr Leu 
1               5                   10                  15      


Leu Val Met Phe Gly Phe Asn Ala Ala Gln Asp Phe Trp Cys Ser Thr 
            20                  25                  30          


Leu Val Lys Gly Val Ile Tyr Gly Ser Tyr Ser Val Ser Glu Met Phe 
        35                  40                  45              


Pro Lys Asn Phe Thr Asn Cys Thr Trp Thr Leu Glu Asn Pro Asp Pro 
    50                  55                  60                  


Thr Lys Tyr Ser Ile Tyr Leu Lys Phe Ser Lys Lys Asp Leu Ser Cys 
65                  70                  75                  80  


Ser Asn Phe Ser Leu Leu Ala Tyr Gln Phe Asp His Phe Ser His Glu 
                85                  90                  95      


Lys Ile Lys Asp Leu Leu Arg Lys Asn His Ser Ile Met Gln Leu Cys 
            100                 105                 110         


Asn Ser Lys Asn Ala Phe Val Phe Leu Gln Tyr Asp Lys Asn Phe Ile 
        115                 120                 125             


Gln Ile Arg Arg Val Phe Pro Thr Asn Phe Pro Gly Leu Gln Lys Lys 
    130                 135                 140                 


Gly Glu Glu Asp Gln Lys Ser Phe Phe Glu Phe Leu Val Leu Asn Lys 
145                 150                 155                 160 


Val Ser Pro Ser Gln Phe Gly Cys His Val Leu Cys Thr Trp Leu Glu 
                165                 170                 175     


Ser Cys Leu Lys Ser Glu Asn Gly Arg Thr Glu Ser Cys Gly Ile Met 
            180                 185                 190         


Tyr Thr Lys Cys Thr Cys Pro Gln His Leu Gly Glu Trp Gly Ile Asp 
        195                 200                 205             


Asp Gln Ser Leu Ile Leu Leu Asn Asn Val Val Leu Pro Leu Asn Glu 
    210                 215                 220                 


Gln Thr Glu Gly Cys Leu Thr Gln Glu Leu Gln Thr Thr Gln Val Cys 
225                 230                 235                 240 


Asn Leu Thr Arg Glu Ala Lys Arg Pro Pro Lys Glu Glu Phe Gly Met 
                245                 250                 255     


Met Gly Asp His Thr Ile Lys Ser Gln Arg Pro Arg Ser Val His Glu 
            260                 265                 270         


Lys Arg Val Pro Gln Glu Gln Ala Asp Ala Ala Lys Phe Met Ala Gln 
        275                 280                 285             


Thr Gly Glu Ser Gly Val Glu Glu Trp Ser Gln Trp Ser Thr Cys Ser 
    290                 295                 300                 


Val Thr Cys Gly Gln Gly Ser Gln Val Arg Thr Arg Thr Cys Val Ser 
305                 310                 315                 320 


Pro Tyr Gly Thr His Cys Ser Gly Pro Leu Arg Glu Ser Arg Val Cys 
                325                 330                 335     


Asn Asn Thr Ala Leu Cys Pro Val His Gly Val Trp Glu Glu Trp Ser 
            340                 345                 350         


Pro Trp Ser Leu Cys Ser Phe Thr Cys Gly Arg Gly Gln Arg Thr Arg 
        355                 360                 365             


Thr Arg Ser Cys Thr Pro Pro Gln Tyr Gly Gly Arg Pro Cys Glu Gly 
    370                 375                 380                 


Pro Glu Thr His His Lys Pro Cys Asn Ile Ala Leu Cys Pro Val Asp 
385                 390                 395                 400 


Gly Gln Trp Gln Glu Trp Ser Ser Trp Ser Gln Cys Ser Val Thr Cys 
                405                 410                 415     


Ser Asn Gly Thr Gln Gln Arg Ser Arg Gln Cys Thr Ala Ala Ala His 
            420                 425                 430         


Gly Gly Ser Glu Cys Arg Gly Pro Trp Ala Glu Ser Arg Glu Cys Tyr 
        435                 440                 445             


Asn Pro Glu Cys Thr Ala Asn Gly Gln Trp Asn Gln Trp Gly His Trp 
    450                 455                 460                 


Ser Gly Cys Ser Lys Ser Cys Asp Gly Gly Trp Glu Arg Arg Ile Arg 
465                 470                 475                 480 


Thr Cys Gln Gly Ala Val Ile Thr Gly Gln Gln Cys Glu Gly Thr Gly 
                485                 490                 495     


Glu Glu Val Arg Arg Cys Ser Glu Gln Arg Cys Pro Ala Pro Tyr Glu 
            500                 505                 510         


Ile Cys Pro Glu Asp Tyr Leu Met Ser Met Val Trp Lys Arg Thr Pro 
        515                 520                 525             


Ala Gly Asp Leu Ala Phe Asn Gln Cys Pro Leu Asn Ala Thr Gly Thr 
    530                 535                 540                 


Thr Ser Arg Arg Cys Ser Leu Ser Leu His Gly Val Ala Phe Trp Glu 
545                 550                 555                 560 


Gln Pro Ser Phe Ala Arg Cys Ile Ser Asn Glu Tyr Arg His Leu Gln 
                565                 570                 575     


His Ser Ile Lys Glu His Leu Ala Lys Gly Gln Arg Met Leu Ala Gly 
            580                 585                 590         


Asp Gly Met Ser Gln Val Thr Lys Thr Leu Leu Asp Leu Thr Gln Arg 
        595                 600                 605             


Lys Asn Phe Tyr Ala Gly Asp Leu Leu Met Ser Val Glu Ile Leu Arg 
    610                 615                 620                 


Asn Val Thr Asp Thr Phe Lys Arg Ala Ser Tyr Ile Pro Ala Ser Asp 
625                 630                 635                 640 


Gly Val Gln Asn Phe Phe Gln Ile Val Ser Asn Leu Leu Asp Glu Glu 
                645                 650                 655     


Asn Lys Glu Lys Trp Glu Asp Ala Gln Gln Ile Tyr Pro Gly Ser Ile 
            660                 665                 670         


Glu Leu Met Gln Val Ile Glu Asp Phe Ile His Ile Val Gly Met Gly 
        675                 680                 685             


Met Met Asp Phe Gln Asn Ser Tyr Leu Met Thr Gly Asn Val Val Ala 
    690                 695                 700                 


Ser Ile Gln Lys Leu Pro Ala Ala Ser Val Leu Thr Asp Ile Asn Phe 
705                 710                 715                 720 


Pro Met Lys Gly Arg Lys Gly Met Val Asp Trp Ala Arg Asn Ser Glu 
                725                 730                 735     


Asp Arg Val Val Ile Pro Lys Ser Ile Phe Thr Pro Val Ser Ser Lys 
            740                 745                 750         


Glu Leu Asp Glu Ser Ser Val Phe Val Leu Gly Ala Val Leu Tyr Lys 
        755                 760                 765             


Asn Leu Asp Leu Ile Leu Pro Thr Leu Arg Asn Tyr Thr Val Ile Asn 
    770                 775                 780                 


Ser Lys Ile Ile Val Val Thr Ile Arg Pro Glu Pro Lys Thr Thr Asp 
785                 790                 795                 800 


Ser Phe Leu Glu Ile Glu Leu Ala His Leu Ala Asn Gly Thr Leu Asn 
                805                 810                 815     


Pro Tyr Cys Val Leu Trp Asp Asp Ser Lys Thr Asn Glu Ser Leu Gly 
            820                 825                 830         


Thr Trp Ser Thr Gln Gly Cys Lys Thr Val Leu Thr Asp Ala Ser His 
        835                 840                 845             


Thr Lys Cys Leu Cys Asp Arg Leu Ser Thr Phe Ala Ile Leu Ala Gln 
    850                 855                 860                 


Gln Pro Arg Glu Ile Ile Met Glu Ser Ser Gly Thr Pro Ser Val Thr 
865                 870                 875                 880 


Leu Ile Val Gly Ser Gly Leu Ser Cys Leu Ala Leu Ile Thr Leu Ala 
                885                 890                 895     


Val Val Tyr Ala Ala Leu Trp Arg Tyr Ile Arg Ser Glu Arg Ser Ile 
            900                 905                 910         


Ile Leu Ile Asn Phe Cys Leu Ser Ile Ile Ser Ser Asn Ile Leu Ile 
        915                 920                 925             


Leu Val Gly Gln Thr Gln Thr His Asn Lys Ser Ile Cys Thr Thr Thr 
    930                 935                 940                 


Thr Ala Phe Leu His Phe Phe Phe Leu Ala Ser Phe Cys Trp Val Leu 
945                 950                 955                 960 


Thr Glu Ala Trp Gln Ser Tyr Met Ala Val Thr Gly Lys Ile Arg Thr 
                965                 970                 975     


Arg Leu Ile Arg Lys Arg Phe Leu Cys Leu Gly Trp Gly Leu Pro Ala 
            980                 985                 990         


Leu Val Val Ala Thr Ser Val Gly  Phe Thr Arg Thr Lys  Gly Tyr Gly 
        995                 1000                 1005             


Thr Asp  His Tyr Cys Trp Leu  Ser Leu Glu Gly Gly  Leu Leu Tyr 
    1010                 1015                 1020             


Ala Phe  Val Gly Pro Ala Ala  Ala Val Val Leu Val  Asn Met Val 
    1025                 1030                 1035             


Ile Gly  Ile Leu Val Phe Asn  Lys Leu Val Ser Arg  Asp Gly Ile 
    1040                 1045                 1050             


Leu Asp  Lys Lys Leu Lys His  Arg Ala Gly Gln Met  Ser Glu Pro 
    1055                 1060                 1065             


His Ser  Gly Leu Thr Leu Lys  Cys Ala Lys Cys Gly  Val Val Ser 
    1070                 1075                 1080             


Thr Thr  Ala Leu Ser Ala Thr  Thr Ala Ser Asn Ala  Met Ala Ser 
    1085                 1090                 1095             


Leu Trp  Ser Ser Cys Val Val  Leu Pro Leu Leu Ala  Leu Thr Trp 
    1100                 1105                 1110             


Met Ser  Ala Val Leu Ala Met  Thr Asp Lys Arg Ser  Ile Leu Phe 
    1115                 1120                 1125             


Gln Ile  Leu Phe Ala Val Phe  Asp Ser Leu Gln Gly  Phe Val Ile 
    1130                 1135                 1140             


Val Met  Val His Cys Ile Leu  Arg Arg Glu Val Gln  Asp Ala Phe 
    1145                 1150                 1155             


Arg Cys  Arg Leu Arg Asn Cys  Gln Asp Pro Ile Asn  Ala Asp Ser 
    1160                 1165                 1170             


Ser Ser  Ser Phe Pro Asn Gly  His Ala Gln Ile Met  Thr Asp Phe 
    1175                 1180                 1185             


Glu Lys  Asp Val Asp Ile Ala  Cys Arg Ser Val Leu  His Lys Asp 
    1190                 1195                 1200             


Ile Gly  Pro Cys Arg Ala Ala  Thr Ile Thr Gly Thr  Leu Ser Arg 
    1205                 1210                 1215             


Ile Ser  Leu Asn Asp Asp Glu  Glu Glu Lys Gly Thr  Asn Pro Glu 
    1220                 1225                 1230             


Gly Leu  Ser Tyr Ser Thr Leu  Pro Gly Asn Val Ile  Ser Lys Val 
    1235                 1240                 1245             


Ile Ile  Gln Gln Pro Thr Gly  Leu His Met Pro Met  Ser Met Asn 
    1250                 1255                 1260             


Glu Leu  Ser Asn Pro Cys Leu  Lys Lys Glu Asn Ser  Glu Leu Arg 
    1265                 1270                 1275             


Arg Thr  Val Tyr Leu Cys Thr  Asp Asp Asn Leu Arg  Gly Ala Asp 
    1280                 1285                 1290             


Met Asp  Ile Val His Pro Gln  Glu Arg Met Met Glu  Ser Asp Tyr 
    1295                 1300                 1305             


Ile Val  Met Pro Arg Ser Ser  Val Asn Asn Gln Pro  Ser Met Lys 
    1310                 1315                 1320             


Glu Glu  Ser Lys Met Asn Ile  Gly Met Glu Thr Leu  Pro His Glu 
    1325                 1330                 1335             


Arg Leu  Leu His Tyr Lys Val  Asn Pro Glu Phe Asn  Met Asn Pro 
    1340                 1345                 1350             


Pro Val  Met Asp Gln Phe Asn  Met Asn Leu Glu Gln  His Leu Ala 
    1355                 1360                 1365             


Pro Gln  Glu His Met Gln Asn  Leu Pro Phe Glu Pro  Arg Thr Ala 
    1370                 1375                 1380             


Val Lys  Asn Phe Met Ala Ser  Glu Leu Asp Asp Asn  Ala Gly Leu 
    1385                 1390                 1395             


Ser Arg  Ser Glu Thr Gly Ser  Thr Ile Ser Met Ser  Ser Leu Glu 
    1400                 1405                 1410             


Arg Arg  Lys Ser Arg Tyr Ser  Asp Leu Asp Phe Glu  Lys Val Met 
    1415                 1420                 1425             


His Thr  Arg Lys Arg His Met  Glu Leu Phe Gln Glu  Leu Asn Gln 
    1430                 1435                 1440             


Lys Phe  Gln Thr Leu Asp Arg  Phe Arg Asp Ile Pro  Asn Thr Ser 
    1445                 1450                 1455             


Ser Met  Glu Asn Pro Ala Pro  Asn Lys Asn Pro Trp  Asp Thr Phe 
    1460                 1465                 1470             


Lys Asn  Pro Ser Glu Tyr Pro  His Tyr Thr Thr Ile  Asn Val Leu 
    1475                 1480                 1485             


Asp Thr  Glu Ala Lys Asp Ala  Leu Glu Leu Arg Pro  Ala Glu Trp 
    1490                 1495                 1500             


Glu Lys  Cys Leu Asn Leu Pro  Leu Asp Val Gln Glu  Gly Asp Phe 
    1505                 1510                 1515             


Gln Thr  Glu Val 
    1520         


<210>  2441
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  2441

Met Arg Lys Met Ser Glu Glu Glu Phe Tyr Leu Phe Lys Asn Ile Ser 
1               5                   10                  15      


Ser Val Gly Pro Trp Asp Gly Pro Gln Tyr His Ile Ala Pro Val Trp 
            20                  25                  30          


Ala Phe Tyr Leu Gln Ala Ala Phe Met Gly Thr Val Phe Leu Ile Gly 
        35                  40                  45              


Phe Pro Leu Asn Ala Met Val Leu Val Ala Thr Leu Arg Tyr Lys Lys 
    50                  55                  60                  


Leu Arg Gln Pro Leu Asn Tyr Ile Leu Val Asn Val Ser Phe Gly Gly 
65                  70                  75                  80  


Phe Leu Leu Cys Ile Phe Ser Val Phe Pro Val Phe Val Ala Ser Cys 
                85                  90                  95      


Asn Gly Tyr Phe Val Phe Gly Arg His Val Cys Ala Leu Glu Gly Phe 
            100                 105                 110         


Leu Gly Thr Val Ala Gly Leu Val Thr Gly Trp Ser Leu Ala Phe Leu 
        115                 120                 125             


Ala Phe Glu Arg Tyr Ile Val Ile Cys Lys Pro Phe Gly Asn Phe Arg 
    130                 135                 140                 


Phe Ser Ser Lys His Ala Leu Thr Val Val Leu Ala Thr Trp Thr Ile 
145                 150                 155                 160 


Gly Ile Gly Val Ser Ile Pro Pro Phe Phe Gly Trp Ser Arg Phe Ile 
                165                 170                 175     


Pro Glu Gly Leu Gln Cys Ser Cys Gly Pro Asp Trp Tyr Thr Val Gly 
            180                 185                 190         


Thr Lys Tyr Arg Ser Glu Ser Tyr Thr Trp Phe Leu Phe Ile Phe Cys 
        195                 200                 205             


Phe Ile Val Pro Leu Ser Leu Ile Cys Phe Ser Tyr Thr Gln Leu Leu 
    210                 215                 220                 


Arg Ala Leu Lys Ala Val Ala Ala Gln Gln Gln Glu Ser Ala Thr Thr 
225                 230                 235                 240 


Gln Lys Ala Glu Arg Glu Val Ser Arg Met Val Val Val Met Val Gly 
                245                 250                 255     


Ser Phe Cys Val Cys Tyr Val Pro Tyr Ala Ala Phe Ala Met Tyr Met 
            260                 265                 270         


Val Asn Asn Arg Asn His Gly Leu Asp Leu Arg Leu Val Thr Ile Pro 
        275                 280                 285             


Ser Phe Phe Ser Lys Ser Ala Cys Ile Tyr Asn Pro Ile Ile Tyr Cys 
    290                 295                 300                 


Phe Met Asn Lys Gln Phe Gln Ala Cys Ile Met Lys Met Val Cys Gly 
305                 310                 315                 320 


Lys Ala Met Thr Asp Glu Ser Asp Thr Cys Ser Ser Gln Lys Thr Glu 
                325                 330                 335     


Val Ser Thr Val Ser Ser Thr Gln Val Gly Pro Asn 
            340                 345             


<210>  2442
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  2442

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  2443
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  2443

Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu 
305                 310                 315                 320 


Leu Ser Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr 
                325                 330                 335     


Val Thr Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp 
            340                 345                 350         


Thr Gly Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser 
        355                 360                 365             


Ser Glu Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn 
    370                 375                 380                 


Pro Val Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn 
385                 390                 395                 400 


Pro Ile Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr 
                405                 410                 415     


Asn Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly 
            420                 425                 430         


Ile Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu 
        435                 440                 445             


Ala Cys Phe Leu His Phe Gly Lys Thr Gly Arg Ala Ser Asp Gln Arg 
    450                 455                 460                 


Asp Leu Thr Glu His Lys Pro Ser Val Ser Asn His Thr Gln Asp His 
465                 470                 475                 480 


Ser Asn Asp Pro Pro Asn Lys Met Asn Glu Val Thr Tyr Ser Thr Leu 
                485                 490                 495     


Asn Phe Glu Ala Gln Gln Pro Thr Gln Pro Thr Ser Ala Ser Pro Ser 
            500                 505                 510         


Leu Thr Ala Thr Glu Ile Ile Tyr Ser Glu Val Lys Lys Gln 
        515                 520                 525     


<210>  2444
<211>  675
<212>  PRT
<213>  Homo sapiens

<400>  2444

Met Asp Thr Lys Ser Ile Leu Glu Glu Leu Leu Leu Lys Arg Ser Gln 
1               5                   10                  15      


Gln Lys Lys Lys Met Ser Pro Asn Asn Tyr Lys Glu Arg Leu Phe Val 
            20                  25                  30          


Leu Thr Lys Thr Asn Leu Ser Tyr Tyr Glu Tyr Asp Lys Met Lys Arg 
        35                  40                  45              


Gly Ser Arg Lys Gly Ser Ile Glu Ile Lys Lys Ile Arg Cys Val Glu 
    50                  55                  60                  


Lys Val Asn Leu Glu Glu Gln Thr Pro Val Glu Arg Gln Tyr Pro Phe 
65                  70                  75                  80  


Gln Ile Val Tyr Lys Asp Gly Leu Leu Tyr Val Tyr Ala Ser Asn Glu 
                85                  90                  95      


Glu Ser Arg Ser Gln Trp Leu Lys Ala Leu Gln Lys Glu Ile Arg Gly 
            100                 105                 110         


Asn Pro His Leu Leu Val Lys Tyr His Ser Gly Phe Phe Val Asp Gly 
        115                 120                 125             


Lys Phe Leu Cys Cys Gln Gln Ser Cys Lys Ala Ala Pro Gly Cys Thr 
    130                 135                 140                 


Leu Trp Glu Ala Tyr Ala Asn Leu His Thr Ala Val Asn Glu Glu Lys 
145                 150                 155                 160 


His Arg Val Pro Thr Phe Pro Asp Arg Val Leu Lys Ile Pro Arg Ala 
                165                 170                 175     


Val Pro Val Leu Lys Met Asp Ala Pro Ser Ser Ser Thr Thr Leu Ala 
            180                 185                 190         


Gln Tyr Asp Asn Glu Ser Lys Lys Asn Tyr Gly Ser Gln Pro Pro Ser 
        195                 200                 205             


Ser Ser Thr Ser Leu Ala Gln Tyr Asp Ser Asn Ser Lys Lys Ile Tyr 
    210                 215                 220                 


Gly Ser Gln Pro Asn Phe Asn Met Gln Tyr Ile Pro Arg Glu Asp Phe 
225                 230                 235                 240 


Pro Asp Trp Trp Gln Val Arg Lys Leu Lys Ser Ser Ser Ser Ser Glu 
                245                 250                 255     


Asp Val Ala Ser Ser Asn Gln Lys Glu Arg Asn Val Asn His Thr Thr 
            260                 265                 270         


Ser Lys Ile Ser Trp Glu Phe Pro Glu Ser Ser Ser Ser Glu Glu Glu 
        275                 280                 285             


Glu Asn Leu Asp Asp Tyr Asp Trp Phe Ala Gly Asn Ile Ser Arg Ser 
    290                 295                 300                 


Gln Ser Glu Gln Leu Leu Arg Gln Lys Gly Lys Glu Gly Ala Phe Met 
305                 310                 315                 320 


Val Arg Asn Ser Ser Gln Val Gly Met Tyr Thr Val Ser Leu Phe Ser 
                325                 330                 335     


Lys Ala Val Asn Asp Lys Lys Gly Thr Val Lys His Tyr His Val His 
            340                 345                 350         


Thr Asn Ala Glu Asn Lys Leu Tyr Leu Ala Glu Asn Tyr Cys Phe Asp 
        355                 360                 365             


Ser Ile Pro Lys Leu Ile His Tyr His Gln His Asn Ser Ala Gly Met 
    370                 375                 380                 


Ile Thr Arg Leu Arg His Pro Val Ser Thr Lys Ala Asn Lys Val Pro 
385                 390                 395                 400 


Asp Ser Val Ser Leu Gly Asn Gly Ile Trp Glu Leu Lys Arg Glu Glu 
                405                 410                 415     


Ile Thr Leu Leu Lys Glu Leu Gly Ser Gly Gln Phe Gly Val Val Gln 
            420                 425                 430         


Leu Gly Lys Trp Lys Gly Gln Tyr Asp Val Ala Val Lys Met Ile Lys 
        435                 440                 445             


Glu Gly Ser Met Ser Glu Asp Glu Phe Phe Gln Glu Ala Gln Thr Met 
    450                 455                 460                 


Met Lys Leu Ser His Pro Lys Leu Val Lys Phe Tyr Gly Val Cys Ser 
465                 470                 475                 480 


Lys Glu Tyr Pro Ile Tyr Ile Val Thr Glu Tyr Ile Ser Asn Gly Cys 
                485                 490                 495     


Leu Leu Asn Tyr Leu Arg Ser His Gly Lys Gly Leu Glu Pro Ser Gln 
            500                 505                 510         


Leu Leu Glu Met Cys Tyr Asp Val Cys Glu Gly Met Ala Phe Leu Glu 
        515                 520                 525             


Ser His Gln Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu Val 
    530                 535                 540                 


Asp Arg Asp Leu Cys Val Lys Val Ser Asp Phe Gly Met Thr Arg Tyr 
545                 550                 555                 560 


Val Leu Asp Asp Gln Tyr Val Ser Ser Val Gly Thr Lys Phe Pro Val 
                565                 570                 575     


Lys Trp Ser Ala Pro Glu Val Phe His Tyr Phe Lys Tyr Ser Ser Lys 
            580                 585                 590         


Ser Asp Val Trp Ala Phe Gly Ile Leu Met Trp Glu Val Phe Ser Leu 
        595                 600                 605             


Gly Lys Gln Pro Tyr Asp Leu Tyr Asp Asn Ser Gln Val Val Leu Lys 
    610                 615                 620                 


Val Ser Gln Gly His Arg Leu Tyr Arg Pro His Leu Ala Ser Asp Thr 
625                 630                 635                 640 


Ile Tyr Gln Ile Met Tyr Ser Cys Trp His Glu Leu Pro Glu Lys Arg 
                645                 650                 655     


Pro Thr Phe Gln Gln Leu Leu Ser Ser Ile Glu Pro Leu Arg Glu Lys 
            660                 665                 670         


Asp Lys His 
        675 


<210>  2445
<211>  2649
<212>  PRT
<213>  Homo sapiens

<400>  2445

Met His Ser Ser Ser Tyr Ser Tyr Arg Ser Ser Asp Ser Val Phe Ser 
1               5                   10                  15      


Asn Thr Thr Ser Thr Arg Thr Ser Leu Asp Ser Asn Glu Asn Leu Leu 
            20                  25                  30          


Leu Val His Cys Gly Pro Thr Leu Ile Asn Ser Cys Ile Ser Phe Gly 
        35                  40                  45              


Ser Glu Ser Phe Asp Gly His Arg Leu Glu Met Leu Gln Gln Ile Ala 
    50                  55                  60                  


Asn Arg Val Gln Arg Asp Ser Val Ile Cys Glu Asp Lys Leu Ile Leu 
65                  70                  75                  80  


Ala Gly Asn Ala Leu Gln Ser Asp Ser Lys Arg Leu Glu Ser Gly Val 
                85                  90                  95      


Gln Phe Gln Asn Glu Ala Glu Ile Ala Gly Tyr Ile Leu Glu Cys Glu 
            100                 105                 110         


Asn Leu Leu Arg Gln His Val Ile Asp Val Gln Ile Leu Ile Asp Gly 
        115                 120                 125             


Lys Tyr Tyr Gln Ala Asp Gln Leu Val Gln Arg Val Ala Lys Leu Arg 
    130                 135                 140                 


Asp Glu Ile Met Ala Leu Arg Asn Glu Cys Ser Ser Val Tyr Ser Lys 
145                 150                 155                 160 


Gly Arg Ile Leu Thr Thr Glu Gln Thr Lys Leu Met Ile Ser Gly Ile 
                165                 170                 175     


Thr Gln Ser Leu Asn Ser Gly Phe Ala Gln Thr Leu His Pro Ser Leu 
            180                 185                 190         


Thr Ser Gly Leu Thr Gln Ser Leu Thr Pro Ser Leu Thr Ser Ser Ser 
        195                 200                 205             


Met Thr Ser Gly Leu Ser Ser Gly Met Thr Ser Arg Leu Thr Pro Ser 
    210                 215                 220                 


Val Thr Pro Ala Tyr Thr Pro Gly Phe Pro Ser Gly Leu Val Pro Asn 
225                 230                 235                 240 


Phe Ser Ser Gly Val Glu Pro Asn Ser Leu Gln Thr Leu Lys Leu Met 
                245                 250                 255     


Gln Ile Arg Lys Pro Leu Leu Lys Ser Ser Leu Leu Asp Gln Asn Leu 
            260                 265                 270         


Thr Glu Glu Glu Ile Asn Met Lys Phe Val Gln Asp Leu Leu Asn Trp 
        275                 280                 285             


Val Asp Glu Met Gln Val Gln Leu Asp Arg Thr Glu Trp Gly Ser Asp 
    290                 295                 300                 


Leu Pro Ser Val Glu Ser His Leu Glu Asn His Lys Asn Val His Arg 
305                 310                 315                 320 


Ala Ile Glu Glu Phe Glu Ser Ser Leu Lys Glu Ala Lys Ile Ser Glu 
                325                 330                 335     


Ile Gln Met Thr Ala Pro Leu Lys Leu Thr Tyr Ala Glu Lys Leu His 
            340                 345                 350         


Arg Leu Glu Ser Gln Tyr Ala Lys Leu Leu Asn Thr Ser Arg Asn Gln 
        355                 360                 365             


Glu Arg His Leu Asp Thr Leu His Asn Phe Val Ser Arg Ala Thr Asn 
    370                 375                 380                 


Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu Val Ala Tyr Asp 
385                 390                 395                 400 


Trp Ser Glu Arg Asn Thr Asn Ile Ala Arg Lys Lys Asp Tyr His Ala 
                405                 410                 415     


Glu Leu Met Arg Glu Leu Asp Gln Lys Glu Glu Asn Ile Lys Ser Val 
            420                 425                 430         


Gln Glu Ile Ala Glu Gln Leu Leu Leu Glu Asn His Pro Ala Arg Leu 
        435                 440                 445             


Thr Ile Glu Ala Tyr Arg Ala Ala Met Gln Thr Gln Trp Ser Trp Ile 
    450                 455                 460                 


Leu Gln Leu Cys Gln Cys Val Glu Gln His Ile Lys Glu Asn Thr Ala 
465                 470                 475                 480 


Tyr Phe Glu Phe Phe Asn Asp Ala Lys Glu Ala Thr Asp Tyr Leu Arg 
                485                 490                 495     


Asn Leu Lys Asp Ala Ile Gln Arg Lys Tyr Ser Cys Asp Arg Ser Ser 
            500                 505                 510         


Ser Ile His Lys Leu Glu Asp Leu Val Gln Glu Ser Met Glu Glu Lys 
        515                 520                 525             


Glu Glu Leu Leu Gln Tyr Lys Ser Thr Ile Ala Asn Leu Met Gly Lys 
    530                 535                 540                 


Ala Lys Thr Ile Ile Gln Leu Lys Pro Arg Asn Ser Asp Cys Pro Leu 
545                 550                 555                 560 


Lys Thr Ser Ile Pro Ile Lys Ala Ile Cys Asp Tyr Arg Gln Ile Glu 
                565                 570                 575     


Ile Thr Ile Tyr Lys Asp Asp Glu Cys Val Leu Ala Asn Asn Ser His 
            580                 585                 590         


Arg Ala Lys Trp Lys Val Ile Ser Pro Thr Gly Asn Glu Ala Met Val 
        595                 600                 605             


Pro Ser Val Cys Phe Thr Val Pro Pro Pro Asn Lys Glu Ala Val Asp 
    610                 615                 620                 


Leu Ala Asn Arg Ile Glu Gln Gln Tyr Gln Asn Val Leu Thr Leu Trp 
625                 630                 635                 640 


His Glu Ser His Ile Asn Met Lys Ser Val Val Ser Trp His Tyr Leu 
                645                 650                 655     


Ile Asn Glu Ile Asp Arg Ile Arg Ala Ser Asn Val Ala Ser Ile Lys 
            660                 665                 670         


Thr Met Leu Pro Gly Glu His Gln Gln Val Leu Ser Asn Leu Gln Ser 
        675                 680                 685             


Arg Phe Glu Asp Phe Leu Glu Asp Ser Gln Glu Ser Gln Val Phe Ser 
    690                 695                 700                 


Gly Ser Asp Ile Thr Gln Leu Glu Lys Glu Val Asn Val Cys Lys Gln 
705                 710                 715                 720 


Tyr Tyr Gln Glu Leu Leu Lys Ser Ala Glu Arg Glu Glu Gln Glu Glu 
                725                 730                 735     


Ser Val Tyr Asn Leu Tyr Ile Ser Glu Val Arg Asn Ile Arg Leu Arg 
            740                 745                 750         


Leu Glu Asn Cys Glu Asp Arg Leu Ile Arg Gln Ile Arg Thr Pro Leu 
        755                 760                 765             


Glu Arg Asp Asp Leu His Glu Ser Val Phe Arg Ile Thr Glu Gln Glu 
    770                 775                 780                 


Lys Leu Lys Lys Glu Leu Glu Arg Leu Lys Asp Asp Leu Gly Thr Ile 
785                 790                 795                 800 


Thr Asn Lys Cys Glu Glu Phe Phe Ser Gln Ala Ala Ala Ser Ser Ser 
                805                 810                 815     


Val Pro Thr Leu Arg Ser Glu Leu Asn Val Val Leu Gln Asn Met Asn 
            820                 825                 830         


Gln Val Tyr Ser Met Ser Ser Thr Tyr Ile Asp Lys Leu Lys Thr Val 
        835                 840                 845             


Asn Leu Val Leu Lys Asn Thr Gln Ala Ala Glu Ala Leu Val Lys Leu 
    850                 855                 860                 


Tyr Glu Thr Lys Leu Cys Glu Glu Glu Ala Val Ile Ala Asp Lys Asn 
865                 870                 875                 880 


Asn Ile Glu Asn Leu Ile Ser Thr Leu Lys Gln Trp Arg Ser Glu Val 
                885                 890                 895     


Asp Glu Lys Arg Gln Val Phe His Ala Leu Glu Asp Glu Leu Gln Lys 
            900                 905                 910         


Ala Lys Ala Ile Ser Asp Glu Met Phe Lys Thr Tyr Lys Glu Arg Asp 
        915                 920                 925             


Leu Asp Phe Asp Trp His Lys Glu Lys Ala Asp Gln Leu Val Glu Arg 
    930                 935                 940                 


Trp Gln Asn Val His Val Gln Ile Asp Asn Arg Leu Arg Asp Leu Glu 
945                 950                 955                 960 


Gly Ile Gly Lys Ser Leu Lys Tyr Tyr Arg Asp Thr Tyr His Pro Leu 
                965                 970                 975     


Asp Asp Trp Ile Gln Gln Val Glu Thr Thr Gln Arg Lys Ile Gln Glu 
            980                 985                 990         


Asn Gln Pro Glu Asn Ser Lys Thr  Leu Ala Thr Gln Leu  Asn Gln Gln 
        995                 1000                 1005             


Lys Met  Leu Val Ser Glu Ile  Glu Met Lys Gln Ser  Lys Met Asp 
    1010                 1015                 1020             


Glu Cys  Gln Lys Tyr Ala Glu  Gln Tyr Ser Ala Thr  Val Lys Asp 
    1025                 1030                 1035             


Tyr Glu  Leu Gln Thr Met Thr  Tyr Arg Ala Met Val  Asp Ser Gln 
    1040                 1045                 1050             


Gln Lys  Ser Pro Val Lys Arg  Arg Arg Met Gln Ser  Ser Ala Asp 
    1055                 1060                 1065             


Leu Ile  Ile Gln Glu Phe Met  Asp Leu Arg Thr Arg  Tyr Thr Ala 
    1070                 1075                 1080             


Leu Val  Thr Leu Met Thr Gln  Tyr Ile Lys Phe Ala  Gly Asp Ser 
    1085                 1090                 1095             


Leu Lys  Arg Leu Glu Glu Glu  Glu Ile Lys Arg Cys  Lys Glu Thr 
    1100                 1105                 1110             


Ser Glu  His Gly Ala Tyr Ser  Asp Leu Leu Gln Arg  Gln Lys Ala 
    1115                 1120                 1125             


Thr Val  Leu Glu Asn Ser Lys  Leu Thr Gly Lys Ile  Ser Glu Leu 
    1130                 1135                 1140             


Glu Arg  Met Val Ala Glu Leu  Lys Lys Gln Lys Ser  Arg Val Glu 
    1145                 1150                 1155             


Glu Glu  Leu Pro Lys Val Arg  Glu Ala Ala Glu Asn  Glu Leu Arg 
    1160                 1165                 1170             


Lys Gln  Gln Arg Asn Val Glu  Asp Ile Ser Leu Gln  Lys Ile Arg 
    1175                 1180                 1185             


Ala Glu  Ser Glu Ala Lys Gln  Tyr Arg Arg Glu Leu  Glu Thr Ile 
    1190                 1195                 1200             


Val Arg  Glu Lys Glu Ala Ala  Glu Arg Glu Leu Glu  Arg Val Arg 
    1205                 1210                 1215             


Gln Leu  Thr Ile Glu Ala Glu  Ala Lys Arg Ala Ala  Val Glu Glu 
    1220                 1225                 1230             


Asn Leu  Leu Asn Phe Arg Asn  Gln Leu Glu Glu Asn  Thr Phe Thr 
    1235                 1240                 1245             


Arg Arg  Thr Leu Glu Asp His  Leu Lys Arg Lys Asp  Leu Ser Leu 
    1250                 1255                 1260             


Asn Asp  Leu Glu Gln Gln Lys  Asn Lys Leu Met Glu  Glu Leu Arg 
    1265                 1270                 1275             


Arg Lys  Arg Asp Asn Glu Glu  Glu Leu Leu Lys Leu  Ile Lys Gln 
    1280                 1285                 1290             


Met Glu  Lys Asp Leu Ala Phe  Gln Lys Gln Val Ala  Glu Lys Gln 
    1295                 1300                 1305             


Leu Lys  Glu Lys Gln Lys Ile  Glu Leu Glu Ala Arg  Arg Lys Ile 
    1310                 1315                 1320             


Thr Glu  Ile Gln Tyr Thr Cys  Arg Glu Asn Ala Leu  Pro Val Cys 
    1325                 1330                 1335             


Pro Ile  Thr Gln Ala Thr Ser  Cys Arg Ala Val Thr  Gly Leu Gln 
    1340                 1345                 1350             


Gln Glu  His Asp Lys Gln Lys  Ala Glu Glu Leu Lys  Gln Gln Val 
    1355                 1360                 1365             


Asp Glu  Leu Thr Ala Ala Asn  Arg Lys Ala Glu Gln  Asp Met Arg 
    1370                 1375                 1380             


Glu Leu  Thr Tyr Glu Leu Asn  Ala Leu Gln Leu Glu  Lys Thr Ser 
    1385                 1390                 1395             


Ser Glu  Glu Lys Ala Arg Leu  Leu Lys Asp Lys Leu  Asp Glu Thr 
    1400                 1405                 1410             


Asn Asn  Thr Leu Arg Cys Leu  Lys Leu Glu Leu Glu  Arg Lys Asp 
    1415                 1420                 1425             


Gln Ala  Glu Lys Gly Tyr Ser  Gln Gln Leu Arg Glu  Leu Gly Arg 
    1430                 1435                 1440             


Gln Leu  Asn Gln Thr Thr Gly  Lys Ala Glu Glu Ala  Met Gln Glu 
    1445                 1450                 1455             


Ala Ser  Asp Leu Lys Lys Ile  Lys Arg Asn Tyr Gln  Leu Glu Leu 
    1460                 1465                 1470             


Glu Ser  Leu Asn His Glu Lys  Gly Lys Leu Gln Arg  Glu Val Asp 
    1475                 1480                 1485             


Arg Ile  Thr Arg Ala His Ala  Val Ala Glu Lys Asn  Ile Gln His 
    1490                 1495                 1500             


Leu Asn  Ser Gln Ile His Ser  Phe Arg Asp Glu Lys  Glu Leu Glu 
    1505                 1510                 1515             


Arg Leu  Gln Ile Cys Gln Arg  Lys Ser Asp His Leu  Lys Glu Gln 
    1520                 1525                 1530             


Phe Glu  Lys Ser His Glu Gln  Leu Leu Gln Asn Ile  Lys Ala Glu 
    1535                 1540                 1545             


Lys Glu  Asn Asn Asp Lys Ile  Gln Arg Leu Asn Glu  Glu Leu Glu 
    1550                 1555                 1560             


Lys Ser  Asn Glu Cys Ala Glu  Met Leu Lys Gln Lys  Val Glu Glu 
    1565                 1570                 1575             


Leu Thr  Arg Gln Asn Asn Glu  Thr Lys Leu Met Met  Gln Arg Ile 
    1580                 1585                 1590             


Gln Ala  Glu Ser Glu Asn Ile  Val Leu Glu Lys Gln  Thr Ile Gln 
    1595                 1600                 1605             


Gln Arg  Cys Glu Ala Leu Lys  Ile Gln Ala Asp Gly  Phe Lys Asp 
    1610                 1615                 1620             


Gln Leu  Arg Ser Thr Asn Glu  His Leu His Lys Gln  Thr Lys Thr 
    1625                 1630                 1635             


Glu Gln  Asp Phe Gln Arg Lys  Ile Lys Cys Leu Glu  Glu Asp Leu 
    1640                 1645                 1650             


Ala Lys  Ser Gln Asn Leu Val  Ser Glu Phe Lys Gln  Lys Cys Asp 
    1655                 1660                 1665             


Gln Gln  Asn Ile Ile Ile Gln  Asn Thr Lys Lys Glu  Val Arg Asn 
    1670                 1675                 1680             


Leu Asn  Ala Glu Leu Asn Ala  Ser Lys Glu Glu Lys  Arg Arg Gly 
    1685                 1690                 1695             


Glu Gln  Lys Val Gln Leu Gln  Gln Ala Gln Val Gln  Glu Leu Asn 
    1700                 1705                 1710             


Asn Arg  Leu Lys Lys Val Gln  Asp Glu Leu His Leu  Lys Thr Ile 
    1715                 1720                 1725             


Glu Glu  Gln Met Thr His Arg  Lys Met Val Leu Phe  Gln Glu Glu 
    1730                 1735                 1740             


Ser Gly  Lys Phe Lys Gln Ser  Ala Glu Glu Phe Arg  Lys Lys Met 
    1745                 1750                 1755             


Glu Lys  Leu Met Glu Ser Lys  Val Ile Thr Glu Asn  Asp Ile Ser 
    1760                 1765                 1770             


Gly Ile  Arg Leu Asp Phe Val  Ser Leu Gln Gln Glu  Asn Ser Arg 
    1775                 1780                 1785             


Ala Gln  Glu Asn Ala Lys Leu  Cys Glu Thr Asn Ile  Lys Glu Leu 
    1790                 1795                 1800             


Glu Arg  Gln Leu Gln Gln Tyr  Arg Glu Gln Met Gln  Gln Gly Gln 
    1805                 1810                 1815             


His Met  Glu Ala Asn His Tyr  Gln Lys Cys Gln Lys  Leu Glu Asp 
    1820                 1825                 1830             


Glu Leu  Ile Ala Gln Lys Arg  Glu Val Glu Asn Leu  Lys Gln Lys 
    1835                 1840                 1845             


Met Asp  Gln Gln Ile Lys Glu  His Glu His Gln Leu  Val Leu Leu 
    1850                 1855                 1860             


Gln Cys  Glu Ile Gln Lys Lys  Ser Thr Ala Lys Asp  Cys Thr Phe 
    1865                 1870                 1875             


Lys Pro  Asp Phe Glu Met Thr  Val Lys Glu Cys Gln  His Ser Gly 
    1880                 1885                 1890             


Glu Leu  Ser Ser Arg Asn Thr  Gly His Leu His Pro  Thr Pro Arg 
    1895                 1900                 1905             


Ser Pro  Leu Leu Arg Trp Thr  Gln Glu Pro Gln Pro  Leu Glu Glu 
    1910                 1915                 1920             


Lys Trp  Gln His Arg Val Val  Glu Gln Ile Pro Lys  Glu Val Gln 
    1925                 1930                 1935             


Phe Gln  Pro Pro Gly Ala Pro  Leu Glu Lys Glu Lys  Ser Gln Gln 
    1940                 1945                 1950             


Cys Tyr  Ser Glu Tyr Phe Ser  Gln Thr Ser Thr Glu  Leu Gln Ile 
    1955                 1960                 1965             


Thr Phe  Asp Glu Thr Asn Pro  Ile Thr Arg Leu Ser  Glu Ile Glu 
    1970                 1975                 1980             


Lys Ile  Arg Asp Gln Ala Leu  Asn Asn Ser Arg Pro  Pro Val Arg 
    1985                 1990                 1995             


Tyr Gln  Asp Asn Ala Cys Glu  Met Glu Leu Val Lys  Val Leu Thr 
    2000                 2005                 2010             


Pro Leu  Glu Ile Ala Lys Asn  Lys Gln Tyr Asp Met  His Thr Glu 
    2015                 2020                 2025             


Val Thr  Thr Leu Lys Gln Glu  Lys Asn Pro Val Pro  Ser Ala Glu 
    2030                 2035                 2040             


Glu Trp  Met Leu Glu Gly Cys  Arg Ala Ser Gly Gly  Leu Lys Lys 
    2045                 2050                 2055             


Gly Asp  Phe Leu Lys Lys Gly  Leu Glu Pro Glu Thr  Phe Gln Asn 
    2060                 2065                 2070             


Phe Asp  Gly Asp His Ala Cys  Ser Val Arg Asp Asp  Glu Phe Lys 
    2075                 2080                 2085             


Phe Gln  Gly Leu Arg His Thr  Val Thr Ala Arg Gln  Leu Val Glu 
    2090                 2095                 2100             


Ala Lys  Leu Leu Asp Met Arg  Thr Ile Glu Gln Leu  Arg Leu Gly 
    2105                 2110                 2115             


Leu Lys  Thr Val Glu Glu Val  Gln Lys Thr Leu Asn  Lys Phe Leu 
    2120                 2125                 2130             


Thr Lys  Ala Thr Ser Ile Ala  Gly Leu Tyr Leu Glu  Ser Thr Lys 
    2135                 2140                 2145             


Glu Lys  Ile Ser Phe Ala Ser  Ala Ala Glu Arg Ile  Ile Ile Asp 
    2150                 2155                 2160             


Lys Met  Val Ala Leu Ala Phe  Leu Glu Ala Gln Ala  Ala Thr Gly 
    2165                 2170                 2175             


Phe Ile  Ile Asp Pro Ile Ser  Gly Gln Thr Tyr Ser  Val Glu Asp 
    2180                 2185                 2190             


Ala Val  Leu Lys Gly Val Val  Asp Pro Glu Phe Arg  Ile Arg Leu 
    2195                 2200                 2205             


Leu Glu  Ala Glu Lys Ala Ala  Val Gly Tyr Ser Tyr  Ser Ser Lys 
    2210                 2215                 2220             


Thr Leu  Ser Val Phe Gln Ala  Met Glu Asn Arg Met  Leu Asp Arg 
    2225                 2230                 2235             


Gln Lys  Gly Lys His Ile Leu  Glu Ala Gln Ile Ala  Ser Gly Gly 
    2240                 2245                 2250             


Val Ile  Asp Pro Val Arg Gly  Ile Arg Val Pro Pro  Glu Ile Ala 
    2255                 2260                 2265             


Leu Gln  Gln Gly Leu Leu Asn  Asn Ala Ile Leu Gln  Phe Leu His 
    2270                 2275                 2280             


Glu Pro  Ser Ser Asn Thr Arg  Val Phe Pro Asn Pro  Asn Asn Lys 
    2285                 2290                 2295             


Gln Ala  Leu Tyr Tyr Ser Glu  Leu Leu Arg Met Cys  Val Phe Asp 
    2300                 2305                 2310             


Val Glu  Ser Gln Cys Phe Leu  Phe Pro Phe Gly Glu  Arg Asn Ile 
    2315                 2320                 2325             


Ser Asn  Leu Asn Val Lys Lys  Thr His Arg Ile Ser  Val Val Asp 
    2330                 2335                 2340             


Thr Lys  Thr Gly Ser Glu Leu  Thr Val Tyr Glu Ala  Phe Gln Arg 
    2345                 2350                 2355             


Asn Leu  Ile Glu Lys Ser Ile  Tyr Leu Glu Leu Ser  Gly Gln Gln 
    2360                 2365                 2370             


Tyr Gln  Trp Lys Glu Ala Met  Phe Phe Glu Ser Tyr  Gly His Ser 
    2375                 2380                 2385             


Ser His  Met Leu Thr Asp Thr  Lys Thr Gly Leu His  Phe Asn Ile 
    2390                 2395                 2400             


Asn Glu  Ala Ile Glu Gln Gly  Thr Ile Asp Lys Ala  Leu Val Lys 
    2405                 2410                 2415             


Lys Tyr  Gln Glu Gly Leu Ile  Thr Leu Thr Glu Leu  Ala Asp Ser 
    2420                 2425                 2430             


Leu Leu  Ser Arg Leu Val Pro  Lys Lys Asp Leu His  Ser Pro Val 
    2435                 2440                 2445             


Ala Gly  Tyr Trp Leu Thr Ala  Ser Gly Glu Arg Ile  Ser Val Leu 
    2450                 2455                 2460             


Lys Ala  Ser Arg Arg Asn Leu  Val Asp Arg Ile Thr  Ala Leu Arg 
    2465                 2470                 2475             


Cys Leu  Glu Ala Gln Val Ser  Thr Gly Gly Ile Ile  Asp Pro Leu 
    2480                 2485                 2490             


Thr Gly  Lys Lys Tyr Arg Val  Ala Glu Ala Leu His  Arg Gly Leu 
    2495                 2500                 2505             


Val Asp  Glu Gly Phe Ala Gln  Gln Leu Arg Gln Cys  Glu Leu Val 
    2510                 2515                 2520             


Ile Thr  Gly Ile Gly His Pro  Ile Thr Asn Lys Met  Met Ser Val 
    2525                 2530                 2535             


Val Glu  Ala Val Asn Ala Asn  Ile Ile Asn Lys Glu  Met Gly Ile 
    2540                 2545                 2550             


Arg Cys  Leu Glu Phe Gln Tyr  Leu Thr Gly Gly Leu  Ile Glu Pro 
    2555                 2560                 2565             


Gln Val  His Ser Arg Leu Ser  Ile Glu Glu Ala Leu  Gln Val Gly 
    2570                 2575                 2580             


Ile Ile  Asp Val Leu Ile Ala  Thr Lys Leu Lys Asp  Gln Lys Ser 
    2585                 2590                 2595             


Tyr Val  Arg Asn Ile Ile Cys  Pro Gln Thr Lys Arg  Lys Leu Thr 
    2600                 2605                 2610             


Tyr Lys  Glu Ala Leu Glu Lys  Ala Asp Phe Asp Phe  His Thr Gly 
    2615                 2620                 2625             


Leu Lys  Leu Leu Glu Val Ser  Glu Pro Leu Met Thr  Gly Ile Ser 
    2630                 2635                 2640             


Ser Leu  Tyr Tyr Ser Ser 
    2645                 


<210>  2446
<211>  487
<212>  PRT
<213>  Homo sapiens

<400>  2446

Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Ala 
1               5                   10                  15      


Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val 
            20                  25                  30          


Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala 
        35                  40                  45              


Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys 
    50                  55                  60                  


Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly 
65                  70                  75                  80  


His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser 
                85                  90                  95      


Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser 
            100                 105                 110         


Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe 
        115                 120                 125             


Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile 
    130                 135                 140                 


Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr 
145                 150                 155                 160 


Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His 
                165                 170                 175     


Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys 
            180                 185                 190         


Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys 
        195                 200                 205             


Val Thr Asn Ser Val Ser Ser Glu Leu Gln Pro Tyr Phe Gln Thr Leu 
    210                 215                 220                 


Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu 
225                 230                 235                 240 


Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys 
                245                 250                 255     


Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro 
            260                 265                 270         


Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly 
        275                 280                 285             


Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala 
    290                 295                 300                 


Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser 
305                 310                 315                 320 


Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val 
                325                 330                 335     


Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser 
            340                 345                 350         


Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro 
        355                 360                 365             


Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala 
    370                 375                 380                 


Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser 
385                 390                 395                 400 


Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu 
                405                 410                 415     


Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu 
            420                 425                 430         


Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val 
        435                 440                 445             


Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val 
    450                 455                 460                 


Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe 
465                 470                 475                 480 


Gly Ala Asp Val Val Tyr Lys 
                485         


<210>  2447
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  2447

Met Ala Gln Arg Gln Pro His Ser Pro Asn Gln Thr Leu Ile Ser Ile 
1               5                   10                  15      


Thr Asn Asp Thr Glu Ser Ser Ser Ser Val Val Ser Asn Asp Asn Thr 
            20                  25                  30          


Asn Lys Gly Trp Ser Gly Asp Asn Ser Pro Gly Ile Glu Ala Leu Cys 
        35                  40                  45              


Ala Ile Tyr Ile Thr Tyr Ala Val Ile Ile Ser Val Gly Ile Leu Gly 
    50                  55                  60                  


Asn Ala Ile Leu Ile Lys Val Phe Phe Lys Thr Lys Ser Met Gln Thr 
65                  70                  75                  80  


Val Pro Asn Ile Phe Ile Thr Ser Leu Ala Phe Gly Asp Leu Leu Leu 
                85                  90                  95      


Leu Leu Thr Cys Val Pro Val Asp Ala Thr His Tyr Leu Ala Glu Gly 
            100                 105                 110         


Trp Leu Phe Gly Arg Ile Gly Cys Lys Val Leu Ser Phe Ile Arg Leu 
        115                 120                 125             


Thr Ser Val Gly Val Ser Val Phe Thr Leu Thr Ile Leu Ser Ala Asp 
    130                 135                 140                 


Arg Tyr Lys Ala Val Val Lys Pro Leu Glu Arg Gln Pro Ser Asn Ala 
145                 150                 155                 160 


Ile Leu Lys Thr Cys Val Lys Ala Gly Cys Val Trp Ile Val Ser Met 
                165                 170                 175     


Ile Phe Ala Leu Pro Glu Ala Ile Phe Ser Asn Val Tyr Thr Phe Arg 
            180                 185                 190         


Asp Pro Asn Lys Asn Met Thr Phe Glu Ser Cys Thr Ser Tyr Pro Val 
        195                 200                 205             


Ser Lys Lys Leu Leu Gln Glu Ile His Ser Leu Leu Cys Phe Leu Val 
    210                 215                 220                 


Phe Tyr Ile Ile Pro Leu Ser Ile Ile Ser Val Tyr Tyr Ser Leu Ile 
225                 230                 235                 240 


Ala Arg Thr Leu Tyr Lys Ser Thr Leu Asn Ile Pro Thr Glu Glu Gln 
                245                 250                 255     


Ser His Ala Arg Lys Gln Ile Glu Ser Arg Lys Arg Ile Ala Arg Thr 
            260                 265                 270         


Val Leu Val Leu Val Ala Leu Phe Ala Leu Cys Trp Leu Pro Asn His 
        275                 280                 285             


Leu Leu Tyr Leu Tyr His Ser Phe Thr Ser Gln Thr Tyr Val Asp Pro 
    290                 295                 300                 


Ser Ala Met His Phe Ile Phe Thr Ile Phe Ser Arg Val Leu Ala Phe 
305                 310                 315                 320 


Ser Asn Ser Cys Val Asn Pro Phe Ala Leu Tyr Trp Leu Ser Lys Ser 
                325                 330                 335     


Phe Gln Lys His Phe Lys Ala Gln Leu Phe Cys Cys Lys Ala Glu Arg 
            340                 345                 350         


Pro Glu Pro Pro Val Ala Asp Thr Ser Leu Thr Thr Leu Ala Val Met 
        355                 360                 365             


Gly Thr Val Pro Gly Thr Gly Ser Ile Gln Met Ser Glu Ile Ser Val 
    370                 375                 380                 


Thr Ser Phe Thr Gly Cys Ser Val Lys Gln Ala Glu Asp Arg Phe 
385                 390                 395                 


<210>  2448
<211>  385
<212>  PRT
<213>  Homo sapiens

<400>  2448

Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr 
1               5                   10                  15      


His Gly Ala Ser Gly Ala Ala Gly Phe Val Gln Ala Pro Leu Ser Gln 
            20                  25                  30          


Gln Arg Trp Val Gly Gly Ser Val Glu Leu His Cys Glu Ala Val Gly 
        35                  40                  45              


Ser Pro Val Pro Glu Ile Gln Trp Trp Phe Glu Gly Gln Gly Pro Asn 
    50                  55                  60                  


Asp Thr Cys Ser Gln Leu Trp Asp Gly Ala Arg Leu Asp Arg Val His 
65                  70                  75                  80  


Ile His Ala Thr Tyr His Gln His Ala Ala Ser Thr Ile Ser Ile Asp 
                85                  90                  95      


Thr Leu Val Glu Glu Asp Thr Gly Thr Tyr Glu Cys Arg Ala Ser Asn 
            100                 105                 110         


Asp Pro Asp Arg Asn His Leu Thr Arg Ala Pro Arg Val Lys Trp Val 
        115                 120                 125             


Arg Ala Gln Ala Val Val Leu Val Leu Glu Pro Gly Thr Val Phe Thr 
    130                 135                 140                 


Thr Val Glu Asp Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn 
145                 150                 155                 160 


Asp Ser Ala Thr Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val 
                165                 170                 175     


Val Leu Lys Glu Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val 
            180                 185                 190         


Asp Ser Asp Asp Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu 
        195                 200                 205             


Pro Met Gly Thr Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys 
    210                 215                 220                 


Ala Val Lys Ser Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu 
225                 230                 235                 240 


Val Cys Lys Ser Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr 
                245                 250                 255     


Lys Ile Thr Asp Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser 
            260                 265                 270         


Arg Phe Phe Val Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu 
        275                 280                 285             


Asn Leu Asn Met Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr 
    290                 295                 300                 


Ser Ser Lys Gly Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser 
305                 310                 315                 320 


His Leu Ala Ala Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu 
                325                 330                 335     


Val Leu Val Thr Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu 
            340                 345                 350         


Asp Val Leu Asp Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser 
        355                 360                 365             


Gly Gln His Gln Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser 
    370                 375                 380                 


Ser 
385 


<210>  2449
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  2449

Met Asp Arg Ala Ala Arg Cys Ser Gly Ala Ser Ser Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Leu Ala Leu Gly Leu Val Ile Leu His Cys Val Val Ala Asp 
            20                  25                  30          


Gly Asn Ser Thr Arg Ser Pro Glu Thr Asn Gly Leu Leu Cys Gly Asp 
        35                  40                  45              


Pro Glu Glu Asn Cys Ala Ala Thr Thr Thr Gln Ser Lys Arg Lys Gly 
    50                  55                  60                  


His Phe Ser Arg Cys Pro Lys Gln Tyr Lys His Tyr Cys Ile Lys Gly 
65                  70                  75                  80  


Arg Cys Arg Phe Val Val Ala Glu Gln Thr Pro Ser Cys Val Cys Asp 
                85                  90                  95      


Glu Gly Tyr Ile Gly Ala Arg Cys Glu Arg Val Asp Leu Phe Tyr Leu 
            100                 105                 110         


Arg Gly Asp Arg Gly Gln Ile Leu Val Ile Cys Leu Ile Ala Val Met 
        115                 120                 125             


Val Val Phe Ile Ile Leu Val Ile Gly Val Cys Thr Cys Cys His Pro 
    130                 135                 140                 


Leu Arg Lys Arg Arg Lys Arg Lys Lys Lys Glu Glu Glu Met Glu Thr 
145                 150                 155                 160 


Leu Gly Lys Asp Ile Thr Pro Ile Asn Glu Asp Ile Glu Glu Thr Asn 
                165                 170                 175     


Ile Ala 
        


<210>  2450
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  2450

Met Ala Val Phe Pro Ser Ser Gly Leu Pro Arg Cys Leu Leu Thr Leu 
1               5                   10                  15      


Ile Leu Leu Gln Leu Pro Lys Leu Asp Ser Ala Pro Phe Asp Val Ile 
            20                  25                  30          


Gly Pro Pro Glu Pro Ile Leu Ala Val Val Gly Glu Asp Ala Glu Leu 
        35                  40                  45              


Pro Cys Arg Leu Ser Pro Asn Ala Ser Ala Glu His Leu Glu Leu Arg 
    50                  55                  60                  


Trp Phe Arg Lys Lys Val Ser Pro Ala Val Leu Val His Arg Asp Gly 
65                  70                  75                  80  


Arg Glu Gln Glu Ala Glu Gln Met Pro Glu Tyr Arg Gly Arg Ala Thr 
                85                  90                  95      


Leu Val Gln Asp Gly Ile Ala Lys Gly Arg Val Ala Leu Arg Ile Arg 
            100                 105                 110         


Gly Val Arg Val Ser Asp Asp Gly Glu Tyr Thr Cys Phe Phe Arg Glu 
        115                 120                 125             


Asp Gly Ser Tyr Glu Glu Ala Leu Val His Leu Lys Val Ala Ala Leu 
    130                 135                 140                 


Gly Ser Asp Pro His Ile Ser Met Gln Val Gln Glu Asn Gly Glu Ile 
145                 150                 155                 160 


Cys Leu Glu Cys Thr Ser Val Gly Trp Tyr Pro Glu Pro Gln Val Gln 
                165                 170                 175     


Trp Arg Thr Ser Lys Gly Glu Lys Phe Pro Ser Thr Ser Glu Ser Arg 
            180                 185                 190         


Asn Pro Asp Glu Glu Gly Leu Phe Thr Val Ala Ala Ser Val Ile Ile 
        195                 200                 205             


Arg Asp Thr Ser Ala Lys Asn Val Ser Cys Tyr Ile Gln Asn Leu Leu 
    210                 215                 220                 


Leu Gly Gln Glu Lys Lys Val Glu Ile Ser Ile Pro Ala Ser Ser Leu 
225                 230                 235                 240 


Pro Arg Leu Thr Pro Trp Ile Val Ala Val Ala Val Ile Leu Met Val 
                245                 250                 255     


Leu Gly Leu Leu Thr Ile Gly Ser Ile Phe Phe Thr Trp Arg Leu Tyr 
            260                 265                 270         


Asn Glu Arg Pro Arg Glu Arg Arg Asn Glu Phe Ser Ser Lys Glu Arg 
        275                 280                 285             


Leu Leu Glu Glu Leu Lys Trp Lys Lys Ala Thr Leu His Ala Val Asp 
    290                 295                 300                 


Val Thr Leu Asp Pro Asp Thr Ala His Pro His Leu Phe Leu Tyr Glu 
305                 310                 315                 320 


Asp Ser Lys Ser Val Arg Leu Glu Asp Ser Arg Gln Lys Leu Pro Glu 
                325                 330                 335     


Lys Thr Glu Arg Phe Asp Ser Trp Pro Cys Val Leu Gly Arg Glu Thr 
            340                 345                 350         


Phe Thr Ser Gly Arg His Tyr Trp Glu Val Glu Val Gly Asp Arg Thr 
        355                 360                 365             


Asp Trp Ala Ile Gly Val Cys Arg Glu Asn Val Met Lys Lys Gly Phe 
    370                 375                 380                 


Asp Pro Met Thr Pro Glu Asn Gly Phe Trp Ala Val Glu Leu Tyr Gly 
385                 390                 395                 400 


Asn Gly Tyr Trp Ala Leu Thr Pro Leu Arg Thr Pro Leu Pro Leu Ala 
                405                 410                 415     


Gly Pro Pro Arg Arg Val Gly Ile Phe Leu Asp Tyr Glu Ser Gly Asp 
            420                 425                 430         


Ile Ser Phe Tyr Asn Met Asn Asp Gly Ser Asp Ile Tyr Thr Phe Ser 
        435                 440                 445             


Asn Val Thr Phe Ser Gly Pro Leu Arg Pro Phe Phe Cys Leu Trp Ser 
    450                 455                 460                 


Ser Gly Lys Lys Pro Leu Thr Ile Cys Pro Ile Ala Asp Gly Pro Glu 
465                 470                 475                 480 


Arg Val Thr Val Ile Ala Asn Ala Gln Asp Leu Ser Lys Glu Ile Pro 
                485                 490                 495     


Leu Ser Pro Met Gly Glu Asp Ser Ala Pro Arg Asp Ala Asp Thr Leu 
            500                 505                 510         


His Ser Lys Leu Ile Pro Thr Gln Pro Ser Gln Gly Ala Pro 
        515                 520                 525     


<210>  2451
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  2451

Met Asn Ser Phe Asn Tyr Thr Thr Pro Asp Tyr Gly His Tyr Asp Asp 
1               5                   10                  15      


Lys Asp Thr Leu Asp Leu Asn Thr Pro Val Asp Lys Thr Ser Asn Thr 
            20                  25                  30          


Leu Arg Val Pro Asp Ile Leu Ala Leu Val Ile Phe Ala Val Val Phe 
        35                  40                  45              


Leu Val Gly Val Leu Gly Asn Ala Leu Val Val Trp Val Thr Ala Phe 
    50                  55                  60                  


Glu Ala Lys Arg Thr Ile Asn Ala Ile Trp Phe Leu Asn Leu Ala Val 
65                  70                  75                  80  


Ala Asp Phe Leu Ser Cys Leu Ala Leu Pro Ile Leu Phe Thr Ser Ile 
                85                  90                  95      


Val Gln His His His Trp Pro Phe Gly Gly Ala Ala Cys Ser Ile Leu 
            100                 105                 110         


Pro Ser Leu Ile Leu Leu Asn Met Tyr Ala Ser Ile Leu Leu Leu Ala 
        115                 120                 125             


Thr Ile Ser Ala Asp Arg Phe Leu Leu Val Phe Lys Pro Ile Trp Cys 
    130                 135                 140                 


Gln Asn Phe Arg Gly Ala Gly Leu Ala Trp Ile Ala Cys Ala Val Ala 
145                 150                 155                 160 


Trp Gly Leu Ala Leu Leu Leu Thr Ile Pro Ser Phe Leu Tyr Arg Val 
                165                 170                 175     


Val Arg Glu Glu Tyr Phe Pro Pro Lys Val Leu Cys Gly Val Asp Tyr 
            180                 185                 190         


Ser His Asp Lys Arg Arg Glu Arg Ala Val Ala Ile Val Arg Leu Val 
        195                 200                 205             


Leu Gly Phe Leu Trp Pro Leu Leu Thr Leu Thr Ile Cys Tyr Thr Phe 
    210                 215                 220                 


Ile Leu Leu Arg Thr Trp Ser Arg Arg Ala Thr Arg Ser Thr Lys Thr 
225                 230                 235                 240 


Leu Lys Val Val Val Ala Val Val Ala Ser Phe Phe Ile Phe Trp Leu 
                245                 250                 255     


Pro Tyr Gln Val Thr Gly Ile Met Met Ser Phe Leu Glu Pro Ser Ser 
            260                 265                 270         


Pro Thr Phe Leu Leu Leu Asn Lys Leu Asp Ser Leu Cys Val Ser Phe 
        275                 280                 285             


Ala Tyr Ile Asn Cys Cys Ile Asn Pro Ile Ile Tyr Val Val Ala Gly 
    290                 295                 300                 


Gln Gly Phe Gln Gly Arg Leu Arg Lys Ser Leu Pro Ser Leu Leu Arg 
305                 310                 315                 320 


Asn Val Leu Thr Glu Glu Ser Val Val Arg Glu Ser Lys Ser Phe Thr 
                325                 330                 335     


Arg Ser Thr Val Asp Thr Met Ala Gln Lys Thr Gln Ala Val 
            340                 345                 350 


<210>  2452
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  2452

Met Arg Phe Thr Phe Thr Ser Arg Cys Leu Ala Leu Phe Leu Leu Leu 
1               5                   10                  15      


Asn His Pro Thr Pro Ile Leu Pro Ala Phe Ser Asn Gln Thr Tyr Pro 
            20                  25                  30          


Thr Ile Glu Pro Lys Pro Phe Leu Tyr Val Val Gly Arg Lys Lys Met 
        35                  40                  45              


Met Asp Ala Gln Tyr Lys Cys Tyr Asp Arg Met Gln Gln Leu Pro Ala 
    50                  55                  60                  


Tyr Gln Gly Glu Gly Pro Tyr Cys Asn Arg Thr Trp Asp Gly Trp Leu 
65                  70                  75                  80  


Cys Trp Asp Asp Thr Pro Ala Gly Val Leu Ser Tyr Gln Phe Cys Pro 
                85                  90                  95      


Asp Tyr Phe Pro Asp Phe Asp Pro Ser Glu Lys Val Thr Lys Tyr Cys 
            100                 105                 110         


Asp Glu Lys Gly Val Trp Phe Lys His Pro Glu Asn Asn Arg Thr Trp 
        115                 120                 125             


Ser Asn Tyr Thr Met Cys Asn Ala Phe Thr Pro Glu Lys Leu Lys Asn 
    130                 135                 140                 


Ala Tyr Val Leu Tyr Tyr Leu Ala Ile Val Gly His Ser Leu Ser Ile 
145                 150                 155                 160 


Phe Thr Leu Val Ile Ser Leu Gly Ile Phe Val Phe Phe Arg Ser Leu 
                165                 170                 175     


Gly Cys Gln Arg Val Thr Leu His Lys Asn Met Phe Leu Thr Tyr Ile 
            180                 185                 190         


Leu Asn Ser Met Ile Ile Ile Ile His Leu Val Glu Val Val Pro Asn 
        195                 200                 205             


Gly Glu Leu Val Arg Arg Asp Pro Val Ser Cys Lys Ile Leu His Phe 
    210                 215                 220                 


Phe His Gln Tyr Met Met Ala Cys Asn Tyr Phe Trp Met Leu Cys Glu 
225                 230                 235                 240 


Gly Ile Tyr Leu His Thr Leu Ile Val Val Ala Val Phe Thr Glu Lys 
                245                 250                 255     


Gln Arg Leu Arg Trp Tyr Tyr Leu Leu Gly Trp Gly Phe Pro Leu Val 
            260                 265                 270         


Pro Thr Thr Ile His Ala Ile Thr Arg Ala Val Tyr Phe Asn Asp Asn 
        275                 280                 285             


Cys Trp Leu Ser Val Glu Thr His Leu Leu Tyr Ile Ile His Gly Pro 
    290                 295                 300                 


Val Met Ala Ala Leu Val Val Asn Phe Phe Phe Leu Leu Asn Ile Val 
305                 310                 315                 320 


Arg Val Leu Val Thr Lys Met Arg Glu Thr His Glu Ala Glu Ser His 
                325                 330                 335     


Met Tyr Leu Lys Ala Val Lys Ala Thr Met Ile Leu Val Pro Leu Leu 
            340                 345                 350         


Gly Ile Gln Phe Val Val Phe Pro Trp Arg Pro Ser Asn Lys Met Leu 
        355                 360                 365             


Gly Lys Ile Tyr Asp Tyr Val Met His Ser Leu Ile His Phe Gln Gly 
    370                 375                 380                 


Phe Phe Val Ala Thr Ile Tyr Cys Phe Cys Asn Asn Glu Val Gln Thr 
385                 390                 395                 400 


Thr Val Lys Arg Gln Trp Ala Gln Phe Lys Ile Gln Trp Asn Gln Arg 
                405                 410                 415     


Trp Gly Arg Arg Pro Ser Asn Arg Ser Ala Arg Ala Ala Ala Ala Ala 
            420                 425                 430         


Ala Glu Ala Gly Asp Ile Pro Ile Tyr Ile Cys His Gln Glu Leu Arg 
        435                 440                 445             


Asn Glu Pro Ala Asn Asn Gln Gly Glu Glu Ser Ala Glu Ile Ile Pro 
    450                 455                 460                 


Leu Asn Ile Ile Glu Gln Glu Ser Ser Ala 
465                 470                 


<210>  2453
<211>  592
<212>  PRT
<213>  Homo sapiens

<400>  2453

Met Glu Gly Lys Trp Leu Leu Cys Met Leu Leu Val Leu Gly Thr Ala 
1               5                   10                  15      


Ile Val Glu Ala His Asp Gly His Asp Asp Asp Val Ile Asp Ile Glu 
            20                  25                  30          


Asp Asp Leu Asp Asp Val Ile Glu Glu Val Glu Asp Ser Lys Pro Asp 
        35                  40                  45              


Thr Thr Ala Pro Pro Ser Ser Pro Lys Val Thr Tyr Lys Ala Pro Val 
    50                  55                  60                  


Pro Thr Gly Glu Val Tyr Phe Ala Asp Ser Phe Asp Arg Gly Thr Leu 
65                  70                  75                  80  


Ser Gly Trp Ile Leu Ser Lys Ala Lys Lys Asp Asp Thr Asp Asp Glu 
                85                  90                  95      


Ile Ala Lys Tyr Asp Gly Lys Trp Glu Val Glu Glu Met Lys Glu Ser 
            100                 105                 110         


Lys Leu Pro Gly Asp Lys Gly Leu Val Leu Met Ser Arg Ala Lys His 
        115                 120                 125             


His Ala Ile Ser Ala Lys Leu Asn Lys Pro Phe Leu Phe Asp Thr Lys 
    130                 135                 140                 


Pro Leu Ile Val Gln Tyr Glu Val Asn Phe Gln Asn Gly Ile Glu Cys 
145                 150                 155                 160 


Gly Gly Ala Tyr Val Lys Leu Leu Ser Lys Thr Pro Glu Leu Asn Leu 
                165                 170                 175     


Asp Gln Phe His Asp Lys Thr Pro Tyr Thr Ile Met Phe Gly Pro Asp 
            180                 185                 190         


Lys Cys Gly Glu Asp Tyr Lys Leu His Phe Ile Phe Arg His Lys Asn 
        195                 200                 205             


Pro Lys Thr Gly Ile Tyr Glu Glu Lys His Ala Lys Arg Pro Asp Ala 
    210                 215                 220                 


Asp Leu Lys Thr Tyr Phe Thr Asp Lys Lys Thr His Leu Tyr Thr Leu 
225                 230                 235                 240 


Ile Leu Asn Pro Asp Asn Ser Phe Glu Ile Leu Val Asp Gln Ser Val 
                245                 250                 255     


Val Asn Ser Gly Asn Leu Leu Asn Asp Met Thr Pro Pro Val Asn Pro 
            260                 265                 270         


Ser Arg Glu Ile Glu Asp Pro Glu Asp Arg Lys Pro Glu Asp Trp Asp 
        275                 280                 285             


Glu Arg Pro Lys Ile Pro Asp Pro Glu Ala Val Lys Pro Asp Asp Trp 
    290                 295                 300                 


Asp Glu Asp Ala Pro Ala Lys Ile Pro Asp Glu Glu Ala Thr Lys Pro 
305                 310                 315                 320 


Glu Gly Trp Leu Asp Asp Glu Pro Glu Tyr Val Pro Asp Pro Asp Ala 
                325                 330                 335     


Glu Lys Pro Glu Asp Trp Asp Glu Asp Met Asp Gly Glu Trp Glu Ala 
            340                 345                 350         


Pro Gln Ile Ala Asn Pro Arg Cys Glu Ser Ala Pro Gly Cys Gly Val 
        355                 360                 365             


Trp Gln Arg Pro Val Ile Asp Asn Pro Asn Tyr Lys Gly Lys Trp Lys 
    370                 375                 380                 


Pro Pro Met Ile Asp Asn Pro Ser Tyr Gln Gly Ile Trp Lys Pro Arg 
385                 390                 395                 400 


Lys Ile Pro Asn Pro Asp Phe Phe Glu Asp Leu Glu Pro Phe Arg Met 
                405                 410                 415     


Thr Pro Phe Ser Ala Ile Gly Leu Glu Leu Trp Ser Met Thr Ser Asp 
            420                 425                 430         


Ile Phe Phe Asp Asn Phe Ile Ile Cys Ala Asp Arg Arg Ile Val Asp 
        435                 440                 445             


Asp Trp Ala Asn Asp Gly Trp Gly Leu Lys Lys Ala Ala Asp Gly Ala 
    450                 455                 460                 


Ala Glu Pro Gly Val Val Gly Gln Met Ile Glu Ala Ala Glu Glu Arg 
465                 470                 475                 480 


Pro Trp Leu Trp Val Val Tyr Ile Leu Thr Val Ala Leu Pro Val Phe 
                485                 490                 495     


Leu Val Ile Leu Phe Cys Cys Ser Gly Lys Lys Gln Thr Ser Gly Met 
            500                 505                 510         


Glu Tyr Lys Lys Thr Asp Ala Pro Gln Pro Asp Val Lys Glu Glu Glu 
        515                 520                 525             


Glu Glu Lys Glu Glu Glu Lys Asp Lys Gly Asp Glu Glu Glu Glu Gly 
    530                 535                 540                 


Glu Glu Lys Leu Glu Glu Lys Gln Lys Ser Asp Ala Glu Glu Asp Gly 
545                 550                 555                 560 


Gly Thr Val Ser Gln Glu Glu Glu Asp Arg Lys Pro Lys Ala Glu Glu 
                565                 570                 575     


Asp Glu Ile Leu Asn Arg Ser Pro Arg Asn Arg Lys Pro Arg Arg Glu 
            580                 585                 590         


<210>  2454
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  2454

Met Ser Gly Gly Lys Tyr Val Asp Ser Glu Gly His Leu Tyr Thr Val 
1               5                   10                  15      


Pro Ile Arg Glu Gln Gly Asn Ile Tyr Lys Pro Asn Asn Lys Ala Met 
            20                  25                  30          


Ala Asp Glu Leu Ser Glu Lys Gln Val Tyr Asp Ala His Thr Lys Glu 
        35                  40                  45              


Ile Asp Leu Val Asn Arg Asp Pro Lys His Leu Asn Asp Asp Val Val 
    50                  55                  60                  


Lys Ile Asp Phe Glu Asp Val Ile Ala Glu Pro Glu Gly Thr His Ser 
65                  70                  75                  80  


Phe Asp Gly Ile Trp Lys Ala Ser Phe Thr Thr Phe Thr Val Thr Lys 
                85                  90                  95      


Tyr Trp Phe Tyr Arg Leu Leu Ser Ala Leu Phe Gly Ile Pro Met Ala 
            100                 105                 110         


Leu Ile Trp Gly Ile Tyr Phe Ala Ile Leu Ser Phe Leu His Ile Trp 
        115                 120                 125             


Ala Val Val Pro Cys Ile Lys Ser Phe Leu Ile Glu Ile Gln Cys Ile 
    130                 135                 140                 


Ser Arg Val Tyr Ser Ile Tyr Val His Thr Val Cys Asp Pro Leu Phe 
145                 150                 155                 160 


Glu Ala Val Gly Lys Ile Phe Ser Asn Val Arg Ile Asn Leu Gln Lys 
                165                 170                 175     


Glu Ile 
        


<210>  2455
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  2455

Met Leu Phe Leu Leu Leu Pro Leu Leu Ala Val Leu Pro Gly Asp Gly 
1               5                   10                  15      


Asn Ala Asp Gly Leu Lys Glu Pro Leu Ser Phe His Val Thr Trp Ile 
            20                  25                  30          


Ala Ser Phe Tyr Asn His Ser Trp Lys Gln Asn Leu Val Ser Gly Trp 
        35                  40                  45              


Leu Ser Asp Leu Gln Thr His Thr Trp Asp Ser Asn Ser Ser Thr Ile 
    50                  55                  60                  


Val Phe Leu Cys Pro Trp Ser Arg Gly Asn Phe Ser Asn Glu Glu Trp 
65                  70                  75                  80  


Lys Glu Leu Glu Thr Leu Phe Arg Ile Arg Thr Ile Arg Ser Phe Glu 
                85                  90                  95      


Gly Ile Arg Arg Tyr Ala His Glu Leu Gln Phe Glu Tyr Pro Phe Glu 
            100                 105                 110         


Ile Gln Val Thr Gly Gly Cys Glu Leu His Ser Gly Lys Val Ser Gly 
        115                 120                 125             


Ser Phe Leu Gln Leu Ala Tyr Gln Gly Ser Asp Phe Val Ser Phe Gln 
    130                 135                 140                 


Asn Asn Ser Trp Leu Pro Tyr Pro Val Ala Gly Asn Met Ala Lys His 
145                 150                 155                 160 


Phe Cys Lys Val Leu Asn Gln Asn Gln His Glu Asn Asp Ile Thr His 
                165                 170                 175     


Asn Leu Leu Ser Asp Thr Cys Pro Arg Phe Ile Leu Gly Leu Leu Asp 
            180                 185                 190         


Ala Gly Lys Ala His Leu Gln Arg Gln Val Lys Pro Glu Ala Trp Leu 
        195                 200                 205             


Ser His Gly Pro Ser Pro Gly Pro Gly His Leu Gln Leu Val Cys His 
    210                 215                 220                 


Val Ser Gly Phe Tyr Pro Lys Pro Val Trp Val Met Trp Met Arg Gly 
225                 230                 235                 240 


Glu Gln Glu Gln Gln Gly Thr Gln Arg Gly Asp Ile Leu Pro Ser Ala 
                245                 250                 255     


Asp Gly Thr Trp Tyr Leu Arg Ala Thr Leu Glu Val Ala Ala Gly Glu 
            260                 265                 270         


Ala Ala Asp Leu Ser Cys Arg Val Lys His Ser Ser Leu Glu Gly Gln 
        275                 280                 285             


Asp Ile Val Leu Tyr Trp Glu His His Ser Ser Val Gly Phe Ile Ile 
    290                 295                 300                 


Leu Ala Val Ile Val Pro Leu Leu Leu Leu Ile Gly Leu Ala Leu Trp 
305                 310                 315                 320 


Phe Arg Lys Arg Cys Phe Cys 
                325         


<210>  2456
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  2456

Met Leu Leu Leu Pro Phe Gln Leu Leu Ala Val Leu Phe Pro Gly Gly 
1               5                   10                  15      


Asn Ser Glu His Ala Phe Gln Gly Pro Thr Ser Phe His Val Ile Gln 
            20                  25                  30          


Thr Ser Ser Phe Thr Asn Ser Thr Trp Ala Gln Thr Gln Gly Ser Gly 
        35                  40                  45              


Trp Leu Asp Asp Leu Gln Ile His Gly Trp Asp Ser Asp Ser Gly Thr 
    50                  55                  60                  


Ala Ile Phe Leu Lys Pro Trp Ser Lys Gly Asn Phe Ser Asp Lys Glu 
65                  70                  75                  80  


Val Ala Glu Leu Glu Glu Ile Phe Arg Val Tyr Ile Phe Gly Phe Ala 
                85                  90                  95      


Arg Glu Val Gln Asp Phe Ala Gly Asp Phe Gln Met Lys Tyr Pro Phe 
            100                 105                 110         


Glu Ile Gln Gly Ile Ala Gly Cys Glu Leu His Ser Gly Gly Ala Ile 
        115                 120                 125             


Val Ser Phe Leu Arg Gly Ala Leu Gly Gly Leu Asp Phe Leu Ser Val 
    130                 135                 140                 


Lys Asn Ala Ser Cys Val Pro Ser Pro Glu Gly Gly Ser Arg Ala Gln 
145                 150                 155                 160 


Lys Phe Cys Ala Leu Ile Ile Gln Tyr Gln Gly Ile Met Glu Thr Val 
                165                 170                 175     


Arg Ile Leu Leu Tyr Glu Thr Cys Pro Arg Tyr Leu Leu Gly Val Leu 
            180                 185                 190         


Asn Ala Gly Lys Ala Asp Leu Gln Arg Gln Val Lys Pro Glu Ala Trp 
        195                 200                 205             


Leu Ser Ser Gly Pro Ser Pro Gly Pro Gly Arg Leu Gln Leu Val Cys 
    210                 215                 220                 


His Val Ser Gly Phe Tyr Pro Lys Pro Val Trp Val Met Trp Met Arg 
225                 230                 235                 240 


Gly Glu Gln Glu Gln Gln Gly Thr Gln Leu Gly Asp Ile Leu Pro Asn 
                245                 250                 255     


Ala Asn Trp Thr Trp Tyr Leu Arg Ala Thr Leu Asp Val Ala Asp Gly 
            260                 265                 270         


Glu Ala Ala Gly Leu Ser Cys Arg Val Lys His Ser Ser Leu Glu Gly 
        275                 280                 285             


Gln Asp Ile Ile Leu Tyr Trp Arg Asn Pro Thr Ser Ile Gly Ser Ile 
    290                 295                 300                 


Val Leu Ala Ile Ile Val Pro Ser Leu Leu Leu Leu Leu Cys Leu Ala 
305                 310                 315                 320 


Leu Trp Tyr Met Arg Arg Arg Ser Tyr Gln Asn Ile Pro 
                325                 330             


<210>  2457
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  2457

Met Leu Phe Leu Gln Phe Leu Leu Leu Ala Leu Leu Leu Pro Gly Gly 
1               5                   10                  15      


Asp Asn Ala Asp Ala Ser Gln Glu His Val Ser Phe His Val Ile Gln 
            20                  25                  30          


Ile Phe Ser Phe Val Asn Gln Ser Trp Ala Arg Gly Gln Gly Ser Gly 
        35                  40                  45              


Trp Leu Asp Glu Leu Gln Thr His Gly Trp Asp Ser Glu Ser Gly Thr 
    50                  55                  60                  


Ile Ile Phe Leu His Asn Trp Ser Lys Gly Asn Phe Ser Asn Glu Glu 
65                  70                  75                  80  


Leu Ser Asp Leu Glu Leu Leu Phe Arg Phe Tyr Leu Phe Gly Leu Thr 
                85                  90                  95      


Arg Glu Ile Gln Asp His Ala Ser Gln Asp Tyr Ser Lys Tyr Pro Phe 
            100                 105                 110         


Glu Val Gln Val Lys Ala Gly Cys Glu Leu His Ser Gly Lys Ser Pro 
        115                 120                 125             


Glu Gly Phe Phe Gln Val Ala Phe Asn Gly Leu Asp Leu Leu Ser Phe 
    130                 135                 140                 


Gln Asn Thr Thr Trp Val Pro Ser Pro Gly Cys Gly Ser Leu Ala Gln 
145                 150                 155                 160 


Ser Val Cys His Leu Leu Asn His Gln Tyr Glu Gly Val Thr Glu Thr 
                165                 170                 175     


Val Tyr Asn Leu Ile Arg Ser Thr Cys Pro Arg Phe Leu Leu Gly Leu 
            180                 185                 190         


Leu Asp Ala Gly Lys Met Tyr Val His Arg Gln Val Arg Pro Glu Ala 
        195                 200                 205             


Trp Leu Ser Ser Arg Pro Ser Leu Gly Ser Gly Gln Leu Leu Leu Val 
    210                 215                 220                 


Cys His Ala Ser Gly Phe Tyr Pro Lys Pro Val Trp Val Thr Trp Met 
225                 230                 235                 240 


Arg Asn Glu Gln Glu Gln Leu Gly Thr Lys His Gly Asp Ile Leu Pro 
                245                 250                 255     


Asn Ala Asp Gly Thr Trp Tyr Leu Gln Val Ile Leu Glu Val Ala Ser 
            260                 265                 270         


Glu Glu Pro Ala Gly Leu Ser Cys Arg Val Arg His Ser Ser Leu Gly 
        275                 280                 285             


Gly Gln Asp Ile Ile Leu Tyr Trp Gly His His Phe Ser Met Asn Trp 
    290                 295                 300                 


Ile Ala Leu Val Val Ile Val Pro Leu Val Ile Leu Ile Val Leu Val 
305                 310                 315                 320 


Leu Trp Phe Lys Lys His Cys Ser Tyr Gln Asp Ile Leu 
                325                 330             


<210>  2458
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  2458

Met Gly Cys Leu Leu Phe Leu Leu Leu Trp Ala Leu Leu Gln Ala Trp 
1               5                   10                  15      


Gly Ser Ala Glu Val Pro Gln Arg Leu Phe Pro Leu Arg Cys Leu Gln 
            20                  25                  30          


Ile Ser Ser Phe Ala Asn Ser Ser Trp Thr Arg Thr Asp Gly Leu Ala 
        35                  40                  45              


Trp Leu Gly Glu Leu Gln Thr His Ser Trp Ser Asn Asp Ser Asp Thr 
    50                  55                  60                  


Val Arg Ser Leu Lys Pro Trp Ser Gln Gly Thr Phe Ser Asp Gln Gln 
65                  70                  75                  80  


Trp Glu Thr Leu Gln His Ile Phe Arg Val Tyr Arg Ser Ser Phe Thr 
                85                  90                  95      


Arg Asp Val Lys Glu Phe Ala Lys Met Leu Arg Leu Ser Tyr Pro Leu 
            100                 105                 110         


Glu Leu Gln Val Ser Ala Gly Cys Glu Val His Pro Gly Asn Ala Ser 
        115                 120                 125             


Asn Asn Phe Phe His Val Ala Phe Gln Gly Lys Asp Ile Leu Ser Phe 
    130                 135                 140                 


Gln Gly Thr Ser Trp Glu Pro Thr Gln Glu Ala Pro Leu Trp Val Asn 
145                 150                 155                 160 


Leu Ala Ile Gln Val Leu Asn Gln Asp Lys Trp Thr Arg Glu Thr Val 
                165                 170                 175     


Gln Trp Leu Leu Asn Gly Thr Cys Pro Gln Phe Val Ser Gly Leu Leu 
            180                 185                 190         


Glu Ser Gly Lys Ser Glu Leu Lys Lys Gln Val Lys Pro Lys Ala Trp 
        195                 200                 205             


Leu Ser Arg Gly Pro Ser Pro Gly Pro Gly Arg Leu Leu Leu Val Cys 
    210                 215                 220                 


His Val Ser Gly Phe Tyr Pro Lys Pro Val Trp Val Lys Trp Met Arg 
225                 230                 235                 240 


Gly Glu Gln Glu Gln Gln Gly Thr Gln Pro Gly Asp Ile Leu Pro Asn 
                245                 250                 255     


Ala Asp Glu Thr Trp Tyr Leu Arg Ala Thr Leu Asp Val Val Ala Gly 
            260                 265                 270         


Glu Ala Ala Gly Leu Ser Cys Arg Val Lys His Ser Ser Leu Glu Gly 
        275                 280                 285             


Gln Asp Ile Val Leu Tyr Trp Gly Gly Ser Tyr Thr Ser Met Gly Leu 
    290                 295                 300                 


Ile Ala Leu Ala Val Leu Ala Cys Leu Leu Phe Leu Leu Ile Val Gly 
305                 310                 315                 320 


Phe Thr Ser Arg Phe Lys Arg Gln Thr Ser Tyr Gln Gly Val Leu 
                325                 330                 335 


<210>  2459
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  2459

Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn 
1               5                   10                  15      


Val Ser Ser Lys Gly Ala Val Ser Lys Glu Ile Thr Asn Ala Leu Glu 
            20                  25                  30          


Thr Trp Gly Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe 
        35                  40                  45              


Gln Met Ser Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp 
    50                  55                  60                  


Lys Lys Lys Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu 
65                  70                  75                  80  


Lys Asp Thr Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His 
                85                  90                  95      


Leu Lys Thr Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr Asp Thr 
            100                 105                 110         


Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu 
        115                 120                 125             


Arg Val Ser Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu 
    130                 135                 140                 


Thr Cys Glu Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln 
145                 150                 155                 160 


Asp Gly Lys His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp 
                165                 170                 175     


Thr Thr Ser Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val 
            180                 185                 190         


Ser Lys Glu Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu 
        195                 200                 205             


Asp Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met 
    210                 215                 220                 


Val Phe Val Ala Leu Leu Val Phe Tyr Ile Thr Lys Arg Lys Lys Gln 
225                 230                 235                 240 


Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr Arg Ala His Arg Val 
                245                 250                 255     


Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln Ile Pro Ala Ser Thr 
            260                 265                 270         


Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro Pro Pro Pro Gly His 
        275                 280                 285             


Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro Pro Gly His Arg Val 
    290                 295                 300                 


Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro Ser Gly Thr Gln Val 
305                 310                 315                 320 


His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro Arg Val Gln Pro Lys 
                325                 330                 335     


Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser Pro Ser Ser Asn 
            340                 345                 350     


<210>  2460
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  2460

Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
        275                 280                 285             


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
    290                 295                 300                 


Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg 
305                 310                 315                 320 


Arg Lys Arg Lys Arg Met Thr Asp Pro Thr Arg Arg Phe Phe Lys Val 
                325                 330                 335     


Thr Pro Pro Pro Gly Ser Gly Pro Gln Asn Gln Tyr Gly Asn Val Leu 
            340                 345                 350         


Ser Leu Pro Thr Pro Thr Ser Gly Leu Gly Arg Ala Gln Arg Trp Ala 
        355                 360                 365             


Ala Gly Leu Gly Gly Thr Ala Pro Ser Tyr Gly Asn Pro Ser Ser Asp 
    370                 375                 380                 


Val Gln Ala Asp Gly Ala Leu Gly Ser Arg Ser Pro Pro Gly Val Gly 
385                 390                 395                 400 


Pro Glu Glu Glu Glu Gly Glu Gly Tyr Glu Glu Pro Asp Ser Glu Glu 
                405                 410                 415     


Asp Ser Glu Phe Tyr Glu Asn Asp Ser Asn Leu Gly Gln Asp Gln Leu 
            420                 425                 430         


Ser Gln Asp Gly Ser Gly Tyr Glu Asn Pro Glu Asp Glu Pro Leu Gly 
        435                 440                 445             


Pro Glu Asp Glu Asp Ser Phe Ser Asn Ala Glu Ser Tyr Glu Asn Glu 
    450                 455                 460                 


Asp Glu Glu Leu Thr Gln Pro Val Ala Arg Thr Met Asp Phe Leu Ser 
465                 470                 475                 480 


Pro His Gly Ser Ala Trp Asp Pro Ser Arg Glu Ala Thr Ser Leu Gly 
                485                 490                 495     


Ser Gln Ser Tyr Glu Asp Met Arg Gly Ile Leu Tyr Ala Ala Pro Gln 
            500                 505                 510         


Leu Arg Ser Ile Arg Gly Gln Pro Gly Pro Asn His Glu Glu Asp Ala 
        515                 520                 525             


Asp Ser Tyr Glu Asn Met Asp Asn Pro Asp Gly Pro Asp Pro Ala Trp 
    530                 535                 540                 


Gly Gly Gly Gly Arg Met Gly Thr Trp Ser Thr Arg 
545                 550                 555     


<210>  2461
<211>  847
<212>  PRT
<213>  Homo sapiens

<400>  2461

Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu 
1               5                   10                  15      


Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu 
            20                  25                  30          


Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala 
        35                  40                  45              


Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr 
    50                  55                  60                  


Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr 
65                  70                  75                  80  


Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly 
                85                  90                  95      


Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn 
            100                 105                 110         


Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp 
        115                 120                 125             


Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His 
    130                 135                 140                 


Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr 
145                 150                 155                 160 


Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp 
                165                 170                 175     


Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser 
            180                 185                 190         


Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro 
        195                 200                 205             


Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala 
    210                 215                 220                 


Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His 
225                 230                 235                 240 


Thr Pro Lys Leu Glu Ile Lys Val Thr Pro Ser Asp Ala Ile Val Arg 
                245                 250                 255     


Glu Gly Asp Ser Val Thr Met Thr Cys Glu Val Ser Ser Ser Asn Pro 
            260                 265                 270         


Glu Tyr Thr Thr Val Ser Trp Leu Lys Asp Gly Thr Ser Leu Lys Lys 
        275                 280                 285             


Gln Asn Thr Phe Thr Leu Asn Leu Arg Glu Val Thr Lys Asp Gln Ser 
    290                 295                 300                 


Gly Lys Tyr Cys Cys Gln Val Ser Asn Asp Val Gly Pro Gly Arg Ser 
305                 310                 315                 320 


Glu Glu Val Phe Leu Gln Val Gln Tyr Ala Pro Glu Pro Ser Thr Val 
                325                 330                 335     


Gln Ile Leu His Ser Pro Ala Val Glu Gly Ser Gln Val Glu Phe Leu 
            340                 345                 350         


Cys Met Ser Leu Ala Asn Pro Leu Pro Thr Asn Tyr Thr Trp Tyr His 
        355                 360                 365             


Asn Gly Lys Glu Met Gln Gly Arg Thr Glu Glu Lys Val His Ile Pro 
    370                 375                 380                 


Lys Ile Leu Pro Trp His Ala Gly Thr Tyr Ser Cys Val Ala Glu Asn 
385                 390                 395                 400 


Ile Leu Gly Thr Gly Gln Arg Gly Pro Gly Ala Glu Leu Asp Val Gln 
                405                 410                 415     


Tyr Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile 
            420                 425                 430         


Arg Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn 
        435                 440                 445             


Pro Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu 
    450                 455                 460                 


Pro Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr 
465                 470                 475                 480 


Thr Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro 
                485                 490                 495     


Val Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val Arg Lys 
            500                 505                 510         


Ile Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser Leu Gln 
        515                 520                 525             


Cys Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe Trp Glu 
    530                 535                 540                 


Lys Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe Asp Ser 
545                 550                 555                 560 


Ile Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn Asn Ser 
                565                 570                 575     


Ile Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu Tyr Ala 
            580                 585                 590         


Pro Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val Met Glu 
        595                 600                 605             


Gly Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro Pro Val 
    610                 615                 620                 


Ser His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro Tyr His 
625                 630                 635                 640 


Ser Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser Gly Ala 
                645                 650                 655     


Tyr Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser Pro Leu 
            660                 665                 670         


Ser Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile Gly Arg Arg Val 
        675                 680                 685             


Ala Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile Cys 
    690                 695                 700                 


Gly Leu Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly 
705                 710                 715                 720 


Leu Gln Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys 
                725                 730                 735     


Val Arg Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr 
            740                 745                 750         


Asn Pro Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro 
        755                 760                 765             


Glu Met Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln 
    770                 775                 780                 


Arg Pro Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His 
785                 790                 795                 800 


Lys Arg Gln Val Gly Asp Tyr Glu Asn Val Ile Pro Asp Phe Pro Glu 
                805                 810                 815     


Asp Glu Gly Ile His Tyr Ser Glu Leu Ile Gln Phe Gly Val Gly Glu 
            820                 825                 830         


Arg Pro Gln Ala Gln Glu Asn Val Asp Tyr Val Ile Leu Lys His 
        835                 840                 845         


<210>  2462
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  2462

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 
        35                  40                  45              


Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 
    50                  55                  60                  


Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 
65                  70                  75                  80  


Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 
                85                  90                  95      


Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 
            100                 105                 110         


Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 
        115                 120                 125             


Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala 
            260                 265                 270         


Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys 
        275                 280                 285             


Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly 
    290                 295                 300                 


Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro Thr 
305                 310                 315                 320 


Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu 
                325                 330                 335     


Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys 
            340                 345                 350         


Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 
        355                 360                 


<210>  2463
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  2463

Met Leu Val Arg Arg Gly Ala Arg Ala Gly Pro Arg Met Pro Arg Gly 
1               5                   10                  15      


Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser Gly Phe Met Ser 
            20                  25                  30          


Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro Thr Gln Gly Thr 
        35                  40                  45              


Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu Thr Thr Thr Pro 
    50                  55                  60                  


Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser Gln His Gly Asn 
65                  70                  75                  80  


Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys Phe Thr Ser Thr 
                85                  90                  95      


Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser Ser Val Gln Ser 
            100                 105                 110         


Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro Ala Asn Val Ser 
        115                 120                 125             


Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro Gly Asn Val Ser 
    130                 135                 140                 


Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser Pro Thr Lys Pro 
145                 150                 155                 160 


Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys Ala Glu Ile Lys 
                165                 170                 175     


Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly Ile Cys Leu Glu 
            180                 185                 190         


Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys Asp Arg Gly Glu 
        195                 200                 205             


Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala Asp Ala Asp Ala 
    210                 215                 220                 


Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser Glu Val Arg Pro 
225                 230                 235                 240 


Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu Ile Ser Ser Lys 
                245                 250                 255     


Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys Lys Leu Gly Ile 
            260                 265                 270         


Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln Ser Tyr Ser Gln 
        275                 280                 285             


Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu Leu Ala Val Leu 
    290                 295                 300                 


Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser Trp Ser Pro Thr 
305                 310                 315                 320 


Gly Glu Arg Leu Glu Leu Glu Pro 
                325             


<210>  2464
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  2464

Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe 
1               5                   10                  15      


Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe 
            20                  25                  30          


Gly Ile Trp Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe Val Gly 
        35                  40                  45              


Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala Ile Ser 
    50                  55                  60                  


Gly Ile Phe Thr Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu 
65                  70                  75                  80  


Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu 
                85                  90                  95      


Leu Phe Ala Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln Arg 
            100                 105                 110         


Ala Gln Leu Glu Arg Ser Leu Arg Asp Val Val Glu Lys Thr Ile Gln 
        115                 120                 125             


Lys Tyr Gly Thr Asn Pro Glu Glu Thr Ala Ala Glu Glu Ser Trp Asp 
    130                 135                 140                 


Tyr Val Gln Phe Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln Asp 
145                 150                 155                 160 


Trp Phe Gln Val Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His Arg 
                165                 170                 175     


Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser Thr Ile 
            180                 185                 190         


Leu Asp Lys Val Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu Ala 
        195                 200                 205             


Arg Ser Arg His Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser His 
    210                 215                 220                 


Ile Tyr Arg Glu Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His Asn 
225                 230                 235                 240 


Asn Leu Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu 
                245                 250                 255     


Leu Gly Phe Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His 
            260                 265                 270         


Val Tyr Asn Arg Leu Ala Arg Tyr Arg 
        275                 280     


<210>  2465
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  2465

Met Ala Asn Cys Glu Phe Ser Pro Val Ser Gly Asp Lys Pro Cys Cys 
1               5                   10                  15      


Arg Leu Ser Arg Arg Ala Gln Leu Cys Leu Gly Val Ser Ile Leu Val 
            20                  25                  30          


Leu Ile Leu Val Val Val Leu Ala Val Val Val Pro Arg Trp Arg Gln 
        35                  40                  45              


Gln Trp Ser Gly Pro Gly Thr Thr Lys Arg Phe Pro Glu Thr Val Leu 
    50                  55                  60                  


Ala Arg Cys Val Lys Tyr Thr Glu Ile His Pro Glu Met Arg His Val 
65                  70                  75                  80  


Asp Cys Gln Ser Val Trp Asp Ala Phe Lys Gly Ala Phe Ile Ser Lys 
                85                  90                  95      


His Pro Cys Asn Ile Thr Glu Glu Asp Tyr Gln Pro Leu Met Lys Leu 
            100                 105                 110         


Gly Thr Gln Thr Val Pro Cys Asn Lys Ile Leu Leu Trp Ser Arg Ile 
        115                 120                 125             


Lys Asp Leu Ala His Gln Phe Thr Gln Val Gln Arg Asp Met Phe Thr 
    130                 135                 140                 


Leu Glu Asp Thr Leu Leu Gly Tyr Leu Ala Asp Asp Leu Thr Trp Cys 
145                 150                 155                 160 


Gly Glu Phe Asn Thr Ser Lys Ile Asn Tyr Gln Ser Cys Pro Asp Trp 
                165                 170                 175     


Arg Lys Asp Cys Ser Asn Asn Pro Val Ser Val Phe Trp Lys Thr Val 
            180                 185                 190         


Ser Arg Arg Phe Ala Glu Ala Ala Cys Asp Val Val His Val Met Leu 
        195                 200                 205             


Asn Gly Ser Arg Ser Lys Ile Phe Asp Lys Asn Ser Thr Phe Gly Ser 
    210                 215                 220                 


Val Glu Val His Asn Leu Gln Pro Glu Lys Val Gln Thr Leu Glu Ala 
225                 230                 235                 240 


Trp Val Ile His Gly Gly Arg Glu Asp Ser Arg Asp Leu Cys Gln Asp 
                245                 250                 255     


Pro Thr Ile Lys Glu Leu Glu Ser Ile Ile Ser Lys Arg Asn Ile Gln 
            260                 265                 270         


Phe Ser Cys Lys Asn Ile Tyr Arg Pro Asp Lys Phe Leu Gln Cys Val 
        275                 280                 285             


Lys Asn Pro Glu Asp Ser Ser Cys Thr Ser Glu Ile 
    290                 295                 300 


<210>  2466
<211>  510
<212>  PRT
<213>  Homo sapiens

<400>  2466

Met Glu Asp Thr Lys Glu Ser Asn Val Lys Thr Phe Cys Ser Lys Asn 
1               5                   10                  15      


Ile Leu Ala Ile Leu Gly Phe Ser Ser Ile Ile Ala Val Ile Ala Leu 
            20                  25                  30          


Leu Ala Val Gly Leu Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys 
        35                  40                  45              


Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile 
    50                  55                  60                  


Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val His Gln 
65                  70                  75                  80  


Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln 
                85                  90                  95      


Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala 
            100                 105                 110         


Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu 
        115                 120                 125             


Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu 
    130                 135                 140                 


Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro 
145                 150                 155                 160 


Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala 
                165                 170                 175     


Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys 
            180                 185                 190         


Thr Arg Trp Phe Ser Ile Val Pro Tyr Glu Thr Asn Asn Gln Glu Thr 
        195                 200                 205             


Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val 
    210                 215                 220                 


Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg 
225                 230                 235                 240 


Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr 
                245                 250                 255     


Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val 
            260                 265                 270         


Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys 
        275                 280                 285             


Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg 
    290                 295                 300                 


Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly 
305                 310                 315                 320 


Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser 
                325                 330                 335     


Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro 
            340                 345                 350         


Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys 
        355                 360                 365             


Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu 
    370                 375                 380                 


Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser 
385                 390                 395                 400 


Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly 
                405                 410                 415     


Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp 
            420                 425                 430         


Ser Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala 
        435                 440                 445             


Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala 
    450                 455                 460                 


Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr Tyr Val Phe Leu 
465                 470                 475                 480 


Met Val Leu Phe Ser Leu Val Leu Phe Thr Val Ala Ile Ile Gly Leu 
                485                 490                 495     


Leu Ile Phe His Lys Pro Ser Tyr Phe Trp Lys Asp Met Val 
            500                 505                 510 


<210>  2467
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  2467

Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 
    290                 295                 300                 


Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met 
305                 310                 315                 320 


Asn Asp Glu 
            


<210>  2468
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  2468

Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly 
            20                  25                  30          


Val Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr 
        35                  40                  45              


Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu 
    50                  55                  60                  


Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr 
65                  70                  75                  80  


Cys Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val 
                85                  90                  95      


Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met 
            100                 105                 110         


Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys 
        115                 120                 125             


Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys 
    130                 135                 140                 


Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met 
145                 150                 155                 160 


Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly 
                165                 170                 175     


Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val 
            180                 185                 190         


Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala 
        195                 200                 205             


Ala Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala 
    210                 215                 220                 


Cys Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met 
225                 230                 235             


<210>  2469
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  2469

Met Ser Ser Glu Asn Cys Phe Val Ala Glu Asn Ser Ser Leu His Pro 
1               5                   10                  15      


Glu Ser Gly Gln Glu Asn Asp Ala Thr Ser Pro His Phe Ser Thr Arg 
            20                  25                  30          


His Glu Gly Ser Phe Gln Val Pro Val Leu Cys Ala Val Met Asn Val 
        35                  40                  45              


Val Phe Ile Thr Ile Leu Ile Ile Ala Leu Ile Ala Leu Ser Val Gly 
    50                  55                  60                  


Gln Tyr Asn Cys Pro Gly Gln Tyr Thr Phe Ser Met Pro Ser Asp Ser 
65                  70                  75                  80  


His Val Ser Ser Cys Ser Glu Asp Trp Val Gly Tyr Gln Arg Lys Cys 
                85                  90                  95      


Tyr Phe Ile Ser Thr Val Lys Arg Ser Trp Thr Ser Ala Gln Asn Ala 
            100                 105                 110         


Cys Ser Glu His Gly Ala Thr Leu Ala Val Ile Asp Ser Glu Lys Asp 
        115                 120                 125             


Met Asn Phe Leu Lys Arg Tyr Ala Gly Arg Glu Glu His Trp Val Gly 
    130                 135                 140                 


Leu Lys Lys Glu Pro Gly His Pro Trp Lys Trp Ser Asn Gly Lys Glu 
145                 150                 155                 160 


Phe Asn Asn Trp Phe Asn Val Thr Gly Ser Asp Lys Cys Val Phe Leu 
                165                 170                 175     


Lys Asn Thr Glu Val Ser Ser Met Glu Cys Glu Lys Asn Leu Tyr Trp 
            180                 185                 190         


Ile Cys Asn Lys Pro Tyr Lys 
        195                 


<210>  2470
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  2470

Met Ala Glu Ala Ile Thr Tyr Ala Asp Leu Arg Phe Val Lys Ala Pro 
1               5                   10                  15      


Leu Lys Lys Ser Ile Ser Ser Arg Leu Gly Gln Asp Pro Gly Ala Asp 
            20                  25                  30          


Asp Asp Gly Glu Ile Thr Tyr Glu Asn Val Gln Val Pro Ala Val Leu 
        35                  40                  45              


Gly Val Pro Ser Ser Leu Ala Ser Ser Val Leu Gly Asp Lys Ala Ala 
    50                  55                  60                  


Val Lys Ser Glu Gln Pro Thr Ala Ser Trp Arg Ala Val Thr Ser Pro 
65                  70                  75                  80  


Ala Val Gly Arg Ile Leu Pro Cys Arg Thr Thr Cys Leu Arg Tyr Leu 
                85                  90                  95      


Leu Leu Gly Leu Leu Leu Thr Cys Leu Leu Leu Gly Val Thr Ala Ile 
            100                 105                 110         


Cys Leu Gly Val Arg Tyr Leu Gln Val Ser Gln Gln Leu Gln Gln Thr 
        115                 120                 125             


Asn Arg Val Leu Glu Val Thr Asn Ser Ser Leu Arg Gln Gln Leu Arg 
    130                 135                 140                 


Leu Lys Ile Thr Gln Leu Gly Gln Ser Ala Glu Asp Leu Gln Gly Ser 
145                 150                 155                 160 


Arg Arg Glu Leu Ala Gln Ser Gln Glu Ala Leu Gln Val Glu Gln Arg 
                165                 170                 175     


Ala His Gln Ala Ala Glu Gly Gln Leu Gln Ala Cys Gln Ala Asp Arg 
            180                 185                 190         


Gln Lys Thr Lys Glu Thr Leu Gln Ser Glu Glu Gln Gln Arg Arg Ala 
        195                 200                 205             


Leu Glu Gln Lys Leu Ser Asn Met Glu Asn Arg Leu Lys Pro Phe Phe 
    210                 215                 220                 


Thr Cys Gly Ser Ala Asp Thr Cys Cys Pro Ser Gly Trp Ile Met His 
225                 230                 235                 240 


Gln Lys Ser Cys Phe Tyr Ile Ser Leu Thr Ser Lys Asn Trp Gln Glu 
                245                 250                 255     


Ser Gln Lys Gln Cys Glu Thr Leu Ser Ser Lys Leu Ala Thr Phe Ser 
            260                 265                 270         


Glu Ile Tyr Pro Gln Ser His Ser Tyr Tyr Phe Leu Asn Ser Leu Leu 
        275                 280                 285             


Pro Asn Gly Gly Ser Gly Asn Ser Tyr Trp Thr Gly Leu Ser Ser Asn 
    290                 295                 300                 


Lys Asp Trp Lys Leu Thr Asp Asp Thr Gln Arg Thr Arg Thr Tyr Ala 
305                 310                 315                 320 


Gln Ser Ser Lys Cys Asn Lys Val His Lys Thr Trp Ser Trp Trp Thr 
                325                 330                 335     


Leu Glu Ser Glu Ser Cys Arg Ser Ser Leu Pro Tyr Ile Cys Glu Met 
            340                 345                 350         


Thr Ala Phe Arg Phe Pro Asp 
        355                 


<210>  2471
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  2471

Met Gly Gly Arg Val Phe Leu Ala Phe Cys Val Trp Leu Thr Leu Pro 
1               5                   10                  15      


Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp Cys Pro Gln 
            20                  25                  30          


Asn Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn Pro Gly Phe 
        35                  40                  45              


Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Thr Glu Thr Cys Asp Asp 
    50                  55                  60                  


Ile Asn Glu Cys Ala Thr Pro Ser Lys Val Ser Cys Gly Lys Phe Ser 
65                  70                  75                  80  


Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly 
                85                  90                  95      


Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu Ser Glu Asn 
            100                 105                 110         


Thr Cys Gln Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp 
        115                 120                 125             


Ser Ser Thr Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys 
    130                 135                 140                 


Arg Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp 
145                 150                 155                 160 


Thr Val Cys Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly 
                165                 170                 175     


Val His Ser Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu 
            180                 185                 190         


Gly Arg Asp Ser Lys Thr Ser Ser Ala Glu Val Thr Ile Gln Asn Val 
        195                 200                 205             


Ile Lys Leu Val Asp Glu Leu Met Glu Ala Pro Gly Asp Val Glu Ala 
    210                 215                 220                 


Leu Ala Pro Pro Val Arg His Leu Ile Ala Thr Gln Leu Leu Ser Asn 
225                 230                 235                 240 


Leu Glu Asp Ile Met Arg Ile Leu Ala Lys Ser Leu Pro Lys Gly Pro 
                245                 250                 255     


Phe Thr Tyr Ile Ser Pro Ser Asn Thr Glu Leu Thr Leu Met Ile Gln 
            260                 265                 270         


Glu Arg Gly Asp Lys Asn Val Thr Met Gly Gln Ser Ser Ala Arg Met 
        275                 280                 285             


Lys Leu Asn Trp Ala Val Ala Ala Gly Ala Glu Asp Pro Gly Pro Ala 
    290                 295                 300                 


Val Ala Gly Ile Leu Ser Ile Gln Asn Met Thr Thr Leu Leu Ala Asn 
305                 310                 315                 320 


Ala Ser Leu Asn Leu His Ser Lys Lys Gln Ala Glu Leu Glu Glu Ile 
                325                 330                 335     


Tyr Glu Ser Ser Ile Arg Gly Val Gln Leu Arg Arg Leu Ser Ala Val 
            340                 345                 350         


Asn Ser Ile Phe Leu Ser His Asn Asn Thr Lys Glu Leu Asn Ser Pro 
        355                 360                 365             


Ile Leu Phe Ala Phe Ser His Leu Glu Ser Ser Asp Gly Glu Ala Gly 
    370                 375                 380                 


Arg Asp Pro Pro Ala Lys Asp Val Met Pro Gly Pro Arg Gln Glu Leu 
385                 390                 395                 400 


Leu Cys Ala Phe Trp Lys Ser Asp Ser Asp Arg Gly Gly His Trp Ala 
                405                 410                 415     


Thr Glu Gly Cys Gln Val Leu Gly Ser Lys Asn Gly Ser Thr Thr Cys 
            420                 425                 430         


Gln Cys Ser His Leu Ser Ser Phe Ala Ile Leu Met Ala His Tyr Asp 
        435                 440                 445             


Val Glu Asp Trp Lys Leu Thr Leu Ile Thr Arg Val Gly Leu Ala Leu 
    450                 455                 460                 


Ser Leu Phe Cys Leu Leu Leu Cys Ile Leu Thr Phe Leu Leu Val Arg 
465                 470                 475                 480 


Pro Ile Gln Gly Ser Arg Thr Thr Ile His Leu His Leu Cys Ile Cys 
                485                 490                 495     


Leu Phe Val Gly Ser Thr Ile Phe Leu Ala Gly Ile Glu Asn Glu Gly 
            500                 505                 510         


Gly Gln Val Gly Leu Arg Cys Arg Leu Val Ala Gly Leu Leu His Tyr 
        515                 520                 525             


Cys Phe Leu Ala Ala Phe Cys Trp Met Ser Leu Glu Gly Leu Glu Leu 
    530                 535                 540                 


Tyr Phe Leu Val Val Arg Val Phe Gln Gly Gln Gly Leu Ser Thr Arg 
545                 550                 555                 560 


Trp Leu Cys Leu Ile Gly Tyr Gly Val Pro Leu Leu Ile Val Gly Val 
                565                 570                 575     


Ser Ala Ala Ile Tyr Ser Lys Gly Tyr Gly Arg Pro Arg Tyr Cys Trp 
            580                 585                 590         


Leu Asp Phe Glu Gln Gly Phe Leu Trp Ser Phe Leu Gly Pro Val Thr 
        595                 600                 605             


Phe Ile Ile Leu Cys Asn Ala Val Ile Phe Val Thr Thr Val Trp Lys 
    610                 615                 620                 


Leu Thr Gln Lys Phe Ser Glu Ile Asn Pro Asp Met Lys Lys Leu Lys 
625                 630                 635                 640 


Lys Ala Arg Ala Leu Thr Ile Thr Ala Ile Ala Gln Leu Phe Leu Leu 
                645                 650                 655     


Gly Cys Thr Trp Val Phe Gly Leu Phe Ile Phe Asp Asp Arg Ser Leu 
            660                 665                 670         


Val Leu Thr Tyr Val Phe Thr Ile Leu Asn Cys Leu Gln Gly Ala Phe 
        675                 680                 685             


Leu Tyr Leu Leu His Cys Leu Leu Asn Lys Lys Val Arg Glu Glu Tyr 
    690                 695                 700                 


Arg Lys Trp Ala Cys Leu Val Ala Gly Gly Ser Lys Tyr Ser Glu Phe 
705                 710                 715                 720 


Thr Ser Thr Thr Ser Gly Thr Gly His Asn Gln Thr Arg Ala Leu Arg 
                725                 730                 735     


Ala Ser Glu Ser Gly Ile 
            740         


<210>  2472
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  2472

Met Cys Arg Ile Ala Gly Ala Leu Arg Thr Leu Leu Pro Leu Leu Ala 
1               5                   10                  15      


Ala Leu Leu Gln Ala Ser Val Glu Ala Ser Gly Glu Ile Ala Leu Cys 
            20                  25                  30          


Lys Thr Gly Phe Pro Glu Asp Val Tyr Ser Ala Val Leu Ser Lys Asp 
        35                  40                  45              


Val His Glu Gly Gln Pro Leu Leu Asn Val Lys Phe Ser Asn Cys Asn 
    50                  55                  60                  


Gly Lys Arg Lys Val Gln Tyr Glu Ser Ser Glu Pro Ala Asp Phe Lys 
65                  70                  75                  80  


Val Asp Glu Asp Gly Met Val Tyr Ala Val Arg Ser Phe Pro Leu Ser 
                85                  90                  95      


Ser Glu His Ala Lys Phe Leu Ile Tyr Ala Gln Asp Lys Glu Thr Gln 
            100                 105                 110         


Glu Lys Trp Gln Val Ala Val Lys Leu Ser Leu Lys Pro Thr Leu Thr 
        115                 120                 125             


Glu Glu Ser Val Lys Glu Ser Ala Glu Val Glu Glu Ile Val Phe Pro 
    130                 135                 140                 


Arg Gln Phe Ser Lys His Ser Gly His Leu Gln Arg Gln Lys Arg Asp 
145                 150                 155                 160 


Trp Val Ile Pro Pro Ile Asn Leu Pro Glu Asn Ser Arg Gly Pro Phe 
                165                 170                 175     


Pro Gln Glu Leu Val Arg Ile Arg Ser Asp Arg Asp Lys Asn Leu Ser 
            180                 185                 190         


Leu Arg Tyr Ser Val Thr Gly Pro Gly Ala Asp Gln Pro Pro Thr Gly 
        195                 200                 205             


Ile Phe Ile Ile Asn Pro Ile Ser Gly Gln Leu Ser Val Thr Lys Pro 
    210                 215                 220                 


Leu Asp Arg Glu Gln Ile Ala Arg Phe His Leu Arg Ala His Ala Val 
225                 230                 235                 240 


Asp Ile Asn Gly Asn Gln Val Glu Asn Pro Ile Asp Ile Val Ile Asn 
                245                 250                 255     


Val Ile Asp Met Asn Asp Asn Arg Pro Glu Phe Leu His Gln Val Trp 
            260                 265                 270         


Asn Gly Thr Val Pro Glu Gly Ser Lys Pro Gly Thr Tyr Val Met Thr 
        275                 280                 285             


Val Thr Ala Ile Asp Ala Asp Asp Pro Asn Ala Leu Asn Gly Met Leu 
    290                 295                 300                 


Arg Tyr Arg Ile Val Ser Gln Ala Pro Ser Thr Pro Ser Pro Asn Met 
305                 310                 315                 320 


Phe Thr Ile Asn Asn Glu Thr Gly Asp Ile Ile Thr Val Ala Ala Gly 
                325                 330                 335     


Leu Asp Arg Glu Lys Val Gln Gln Tyr Thr Leu Ile Ile Gln Ala Thr 
            340                 345                 350         


Asp Met Glu Gly Asn Pro Thr Tyr Gly Leu Ser Asn Thr Ala Thr Ala 
        355                 360                 365             


Val Ile Thr Val Thr Asp Val Asn Asp Asn Pro Pro Glu Phe Thr Ala 
    370                 375                 380                 


Met Thr Phe Tyr Gly Glu Val Pro Glu Asn Arg Val Asp Ile Ile Val 
385                 390                 395                 400 


Ala Asn Leu Thr Val Thr Asp Lys Asp Gln Pro His Thr Pro Ala Trp 
                405                 410                 415     


Asn Ala Val Tyr Arg Ile Ser Gly Gly Asp Pro Thr Gly Arg Phe Ala 
            420                 425                 430         


Ile Gln Thr Asp Pro Asn Ser Asn Asp Gly Leu Val Thr Val Val Lys 
        435                 440                 445             


Pro Ile Asp Phe Glu Thr Asn Arg Met Phe Val Leu Thr Val Ala Ala 
    450                 455                 460                 


Glu Asn Gln Val Pro Leu Ala Lys Gly Ile Gln His Pro Pro Gln Ser 
465                 470                 475                 480 


Thr Ala Thr Val Ser Val Thr Val Ile Asp Val Asn Glu Asn Pro Tyr 
                485                 490                 495     


Phe Ala Pro Asn Pro Lys Ile Ile Arg Gln Glu Glu Gly Leu His Ala 
            500                 505                 510         


Gly Thr Met Leu Thr Thr Phe Thr Ala Gln Asp Pro Asp Arg Tyr Met 
        515                 520                 525             


Gln Gln Asn Ile Arg Tyr Thr Lys Leu Ser Asp Pro Ala Asn Trp Leu 
    530                 535                 540                 


Lys Ile Asp Pro Val Asn Gly Gln Ile Thr Thr Ile Ala Val Leu Asp 
545                 550                 555                 560 


Arg Glu Ser Pro Asn Val Lys Asn Asn Ile Tyr Asn Ala Thr Phe Leu 
                565                 570                 575     


Ala Ser Asp Asn Gly Ile Pro Pro Met Ser Gly Thr Gly Thr Leu Gln 
            580                 585                 590         


Ile Tyr Leu Leu Asp Ile Asn Asp Asn Ala Pro Gln Val Leu Pro Gln 
        595                 600                 605             


Glu Ala Glu Thr Cys Glu Thr Pro Asp Pro Asn Ser Ile Asn Ile Thr 
    610                 615                 620                 


Ala Leu Asp Tyr Asp Ile Asp Pro Asn Ala Gly Pro Phe Ala Phe Asp 
625                 630                 635                 640 


Leu Pro Leu Ser Pro Val Thr Ile Lys Arg Asn Trp Thr Ile Thr Arg 
                645                 650                 655     


Leu Asn Gly Asp Phe Ala Gln Leu Asn Leu Lys Ile Lys Phe Leu Glu 
            660                 665                 670         


Ala Gly Ile Tyr Glu Val Pro Ile Ile Ile Thr Asp Ser Gly Asn Pro 
        675                 680                 685             


Pro Lys Ser Asn Ile Ser Ile Leu Arg Val Lys Val Cys Gln Cys Asp 
    690                 695                 700                 


Ser Asn Gly Asp Cys Thr Asp Val Asp Arg Ile Val Gly Ala Gly Leu 
705                 710                 715                 720 


Gly Thr Gly Ala Ile Ile Ala Ile Leu Leu Cys Ile Ile Ile Leu Leu 
                725                 730                 735     


Ile Leu Val Leu Met Phe Val Val Trp Met Lys Arg Arg Asp Lys Glu 
            740                 745                 750         


Arg Gln Ala Lys Gln Leu Leu Ile Asp Pro Glu Asp Asp Val Arg Asp 
        755                 760                 765             


Asn Ile Leu Lys Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp 
    770                 775                 780                 


Tyr Asp Leu Ser Gln Leu Gln Gln Pro Asp Thr Val Glu Pro Asp Ala 
785                 790                 795                 800 


Ile Lys Pro Val Gly Ile Arg Arg Met Asp Glu Arg Pro Ile His Ala 
                805                 810                 815     


Glu Pro Gln Tyr Pro Val Arg Ser Ala Ala Pro His Pro Gly Asp Ile 
            820                 825                 830         


Gly Asp Phe Ile Asn Glu Gly Leu Lys Ala Ala Asp Asn Asp Pro Thr 
        835                 840                 845             


Ala Pro Pro Tyr Asp Ser Leu Leu Val Phe Asp Tyr Glu Gly Ser Gly 
    850                 855                 860                 


Ser Thr Ala Gly Ser Leu Ser Ser Leu Asn Ser Ser Ser Ser Gly Gly 
865                 870                 875                 880 


Glu Gln Asp Tyr Asp Tyr Leu Asn Asp Trp Gly Pro Arg Phe Lys Lys 
                885                 890                 895     


Leu Ala Asp Met Tyr Gly Gly Gly Asp Asp 
            900                 905     


<210>  2473
<211>  829
<212>  PRT
<213>  Homo sapiens

<400>  2473

Met Gly Leu Pro Arg Gly Pro Leu Ala Ser Leu Leu Leu Leu Gln Val 
1               5                   10                  15      


Cys Trp Leu Gln Cys Ala Ala Ser Glu Pro Cys Arg Ala Val Phe Arg 
            20                  25                  30          


Glu Ala Glu Val Thr Leu Glu Ala Gly Gly Ala Glu Gln Glu Pro Gly 
        35                  40                  45              


Gln Ala Leu Gly Lys Val Phe Met Gly Cys Pro Gly Gln Glu Pro Ala 
    50                  55                  60                  


Leu Phe Ser Thr Asp Asn Asp Asp Phe Thr Val Arg Asn Gly Glu Thr 
65                  70                  75                  80  


Val Gln Glu Arg Arg Ser Leu Lys Glu Arg Asn Pro Leu Lys Ile Phe 
                85                  90                  95      


Pro Ser Lys Arg Ile Leu Arg Arg His Lys Arg Asp Trp Val Val Ala 
            100                 105                 110         


Pro Ile Ser Val Pro Glu Asn Gly Lys Gly Pro Phe Pro Gln Arg Leu 
        115                 120                 125             


Asn Gln Leu Lys Ser Asn Lys Asp Arg Asp Thr Lys Ile Phe Tyr Ser 
    130                 135                 140                 


Ile Thr Gly Pro Gly Ala Asp Ser Pro Pro Glu Gly Val Phe Ala Val 
145                 150                 155                 160 


Glu Lys Glu Thr Gly Trp Leu Leu Leu Asn Lys Pro Leu Asp Arg Glu 
                165                 170                 175     


Glu Ile Ala Lys Tyr Glu Leu Phe Gly His Ala Val Ser Glu Asn Gly 
            180                 185                 190         


Ala Ser Val Glu Asp Pro Met Asn Ile Ser Ile Ile Val Thr Asp Gln 
        195                 200                 205             


Asn Asp His Lys Pro Lys Phe Thr Gln Asp Thr Phe Arg Gly Ser Val 
    210                 215                 220                 


Leu Glu Gly Val Leu Pro Gly Thr Ser Val Met Gln Val Thr Ala Thr 
225                 230                 235                 240 


Asp Glu Asp Asp Ala Ile Tyr Thr Tyr Asn Gly Val Val Ala Tyr Ser 
                245                 250                 255     


Ile His Ser Gln Glu Pro Lys Asp Pro His Asp Leu Met Phe Thr Ile 
            260                 265                 270         


His Arg Ser Thr Gly Thr Ile Ser Val Ile Ser Ser Gly Leu Asp Arg 
        275                 280                 285             


Glu Lys Val Pro Glu Tyr Thr Leu Thr Ile Gln Ala Thr Asp Met Asp 
    290                 295                 300                 


Gly Asp Gly Ser Thr Thr Thr Ala Val Ala Val Val Glu Ile Leu Asp 
305                 310                 315                 320 


Ala Asn Asp Asn Ala Pro Met Phe Asp Pro Gln Lys Tyr Glu Ala His 
                325                 330                 335     


Val Pro Glu Asn Ala Val Gly His Glu Val Gln Arg Leu Thr Val Thr 
            340                 345                 350         


Asp Leu Asp Ala Pro Asn Ser Pro Ala Trp Arg Ala Thr Tyr Leu Ile 
        355                 360                 365             


Met Gly Gly Asp Asp Gly Asp His Phe Thr Ile Thr Thr His Pro Glu 
    370                 375                 380                 


Ser Asn Gln Gly Ile Leu Thr Thr Arg Lys Gly Leu Asp Phe Glu Ala 
385                 390                 395                 400 


Lys Asn Gln His Thr Leu Tyr Val Glu Val Thr Asn Glu Ala Pro Phe 
                405                 410                 415     


Val Leu Lys Leu Pro Thr Ser Thr Ala Thr Ile Val Val His Val Glu 
            420                 425                 430         


Asp Val Asn Glu Ala Pro Val Phe Val Pro Pro Ser Lys Val Val Glu 
        435                 440                 445             


Val Gln Glu Gly Ile Pro Thr Gly Glu Pro Val Cys Val Tyr Thr Ala 
    450                 455                 460                 


Glu Asp Pro Asp Lys Glu Asn Gln Lys Ile Ser Tyr Arg Ile Leu Arg 
465                 470                 475                 480 


Asp Pro Ala Gly Trp Leu Ala Met Asp Pro Asp Ser Gly Gln Val Thr 
                485                 490                 495     


Ala Val Gly Thr Leu Asp Arg Glu Asp Glu Gln Phe Val Arg Asn Asn 
            500                 505                 510         


Ile Tyr Glu Val Met Val Leu Ala Met Asp Asn Gly Ser Pro Pro Thr 
        515                 520                 525             


Thr Gly Thr Gly Thr Leu Leu Leu Thr Leu Ile Asp Val Asn Asp His 
    530                 535                 540                 


Gly Pro Val Pro Glu Pro Arg Gln Ile Thr Ile Cys Asn Gln Ser Pro 
545                 550                 555                 560 


Val Arg Gln Val Leu Asn Ile Thr Asp Lys Asp Leu Ser Pro His Thr 
                565                 570                 575     


Ser Pro Phe Gln Ala Gln Leu Thr Asp Asp Ser Asp Ile Tyr Trp Thr 
            580                 585                 590         


Ala Glu Val Asn Glu Glu Gly Asp Thr Val Val Leu Ser Leu Lys Lys 
        595                 600                 605             


Phe Leu Lys Gln Asp Thr Tyr Asp Val His Leu Ser Leu Ser Asp His 
    610                 615                 620                 


Gly Asn Lys Glu Gln Leu Thr Val Ile Arg Ala Thr Val Cys Asp Cys 
625                 630                 635                 640 


His Gly His Val Glu Thr Cys Pro Gly Pro Trp Lys Gly Gly Phe Ile 
                645                 650                 655     


Leu Pro Val Leu Gly Ala Val Leu Ala Leu Leu Phe Leu Leu Leu Val 
            660                 665                 670         


Leu Leu Leu Leu Val Arg Lys Lys Arg Lys Ile Lys Glu Pro Leu Leu 
        675                 680                 685             


Leu Pro Glu Asp Asp Thr Arg Asp Asn Val Phe Tyr Tyr Gly Glu Glu 
    690                 695                 700                 


Gly Gly Gly Glu Glu Asp Gln Asp Tyr Asp Ile Thr Gln Leu His Arg 
705                 710                 715                 720 


Gly Leu Glu Ala Arg Pro Glu Val Val Leu Arg Asn Asp Val Ala Pro 
                725                 730                 735     


Thr Ile Ile Pro Thr Pro Met Tyr Arg Pro Arg Pro Ala Asn Pro Asp 
            740                 745                 750         


Glu Ile Gly Asn Phe Ile Ile Glu Asn Leu Lys Ala Ala Asn Thr Asp 
        755                 760                 765             


Pro Thr Ala Pro Pro Tyr Asp Thr Leu Leu Val Phe Asp Tyr Glu Gly 
    770                 775                 780                 


Ser Gly Ser Asp Ala Ala Ser Leu Ser Ser Leu Thr Ser Ser Ala Ser 
785                 790                 795                 800 


Asp Gln Asp Gln Asp Tyr Asp Tyr Leu Asn Glu Trp Gly Ser Arg Phe 
                805                 810                 815     


Lys Lys Leu Ala Asp Met Tyr Gly Gly Gly Glu Asp Asp 
            820                 825                 


<210>  2474
<211>  916
<212>  PRT
<213>  Homo sapiens

<400>  2474

Met Thr Ala Gly Ala Gly Val Leu Leu Leu Leu Leu Ser Leu Ser Gly 
1               5                   10                  15      


Ala Leu Arg Ala His Asn Glu Asp Leu Thr Thr Arg Glu Thr Cys Lys 
            20                  25                  30          


Ala Gly Phe Ser Glu Asp Asp Tyr Thr Ala Leu Ile Ser Gln Asn Ile 
        35                  40                  45              


Leu Glu Gly Glu Lys Leu Leu Gln Val Lys Phe Ser Ser Cys Val Gly 
    50                  55                  60                  


Thr Lys Gly Thr Gln Tyr Glu Thr Asn Ser Met Asp Phe Lys Val Gly 
65                  70                  75                  80  


Ala Asp Gly Thr Val Phe Ala Thr Arg Glu Leu Gln Val Pro Ser Glu 
                85                  90                  95      


Gln Val Ala Phe Thr Val Thr Ala Trp Asp Ser Gln Thr Ala Glu Lys 
            100                 105                 110         


Trp Asp Ala Val Val Arg Leu Leu Val Ala Gln Thr Ser Ser Pro His 
        115                 120                 125             


Ser Gly His Lys Pro Gln Lys Gly Lys Lys Val Val Ala Leu Asp Pro 
    130                 135                 140                 


Ser Pro Pro Pro Lys Asp Thr Leu Leu Pro Trp Pro Gln His Gln Asn 
145                 150                 155                 160 


Ala Asn Gly Leu Arg Arg Arg Lys Arg Asp Trp Val Ile Pro Pro Ile 
                165                 170                 175     


Asn Val Pro Glu Asn Ser Arg Gly Pro Phe Pro Gln Gln Leu Val Arg 
            180                 185                 190         


Ile Arg Ser Asp Lys Asp Asn Asp Ile Pro Ile Arg Tyr Ser Ile Thr 
        195                 200                 205             


Gly Val Gly Ala Asp Gln Pro Pro Met Glu Val Phe Ser Ile Asp Ser 
    210                 215                 220                 


Met Ser Gly Arg Met Tyr Val Thr Arg Pro Met Asp Arg Glu Glu His 
225                 230                 235                 240 


Ala Ser Tyr His Leu Arg Ala His Ala Val Asp Met Asn Gly Asn Lys 
                245                 250                 255     


Val Glu Asn Pro Ile Asp Leu Tyr Ile Tyr Val Ile Asp Met Asn Asp 
            260                 265                 270         


Asn Arg Pro Glu Phe Ile Asn Gln Val Tyr Asn Gly Ser Val Asp Glu 
        275                 280                 285             


Gly Ser Lys Pro Gly Thr Tyr Val Met Thr Val Thr Ala Asn Asp Ala 
    290                 295                 300                 


Asp Asp Ser Thr Thr Ala Asn Gly Met Val Arg Tyr Arg Ile Val Thr 
305                 310                 315                 320 


Gln Thr Pro Gln Ser Pro Ser Gln Asn Met Phe Thr Ile Asn Ser Glu 
                325                 330                 335     


Thr Gly Asp Ile Val Thr Val Ala Ala Gly Leu Asp Arg Glu Lys Val 
            340                 345                 350         


Gln Gln Tyr Thr Val Ile Val Gln Ala Thr Asp Met Glu Gly Asn Leu 
        355                 360                 365             


Asn Tyr Gly Leu Ser Asn Thr Ala Thr Ala Ile Ile Thr Val Thr Asp 
    370                 375                 380                 


Val Asn Asp Asn Pro Pro Glu Phe Thr Ala Ser Thr Phe Ala Gly Glu 
385                 390                 395                 400 


Val Pro Glu Asn Arg Val Glu Thr Val Val Ala Asn Leu Thr Val Met 
                405                 410                 415     


Asp Arg Asp Gln Pro His Ser Pro Asn Trp Asn Ala Val Tyr Arg Ile 
            420                 425                 430         


Ile Ser Gly Asp Pro Ser Gly His Phe Ser Val Arg Thr Asp Pro Val 
        435                 440                 445             


Thr Asn Glu Gly Met Val Thr Val Val Lys Ala Val Asp Tyr Glu Leu 
    450                 455                 460                 


Asn Arg Ala Phe Met Leu Thr Val Met Val Ser Asn Gln Ala Pro Leu 
465                 470                 475                 480 


Ala Ser Gly Ile Gln Met Ser Phe Gln Ser Thr Ala Gly Val Thr Ile 
                485                 490                 495     


Ser Ile Met Asp Ile Asn Glu Ala Pro Tyr Phe Pro Ser Asn His Lys 
            500                 505                 510         


Leu Ile Arg Leu Glu Glu Gly Val Pro Pro Gly Thr Val Leu Thr Thr 
        515                 520                 525             


Phe Ser Ala Val Asp Pro Asp Arg Phe Met Gln Gln Ala Val Arg Tyr 
    530                 535                 540                 


Ser Lys Leu Ser Asp Pro Ala Ser Trp Leu His Ile Asn Ala Thr Asn 
545                 550                 555                 560 


Gly Gln Ile Thr Thr Ala Ala Val Leu Asp Arg Glu Ser Leu Tyr Thr 
                565                 570                 575     


Lys Asn Asn Val Tyr Glu Ala Thr Phe Leu Ala Ala Asp Asn Gly Ile 
            580                 585                 590         


Pro Pro Ala Ser Gly Thr Gly Thr Leu Gln Ile Tyr Leu Ile Asp Ile 
        595                 600                 605             


Asn Asp Asn Ala Pro Glu Leu Leu Pro Lys Glu Ala Gln Ile Cys Glu 
    610                 615                 620                 


Lys Pro Asn Leu Asn Ala Ile Asn Ile Thr Ala Ala Asp Ala Asp Val 
625                 630                 635                 640 


Asp Pro Asn Ile Gly Pro Tyr Val Phe Glu Leu Pro Phe Val Pro Ala 
                645                 650                 655     


Ala Val Arg Lys Asn Trp Thr Ile Thr Arg Leu Asn Gly Asp Tyr Ala 
            660                 665                 670         


Gln Leu Ser Leu Arg Ile Leu Tyr Leu Glu Ala Gly Met Tyr Asp Val 
        675                 680                 685             


Pro Ile Ile Val Thr Asp Ser Gly Asn Pro Pro Leu Ser Asn Thr Ser 
    690                 695                 700                 


Ile Ile Lys Val Lys Val Cys Pro Cys Asp Asp Asn Gly Asp Cys Thr 
705                 710                 715                 720 


Thr Ile Gly Ala Val Ala Ala Ala Gly Leu Gly Thr Gly Ala Ile Val 
                725                 730                 735     


Ala Ile Leu Ile Cys Ile Leu Ile Leu Leu Thr Met Val Leu Leu Phe 
            740                 745                 750         


Val Met Trp Met Lys Arg Arg Glu Lys Glu Arg His Thr Lys Gln Leu 
        755                 760                 765             


Leu Ile Asp Pro Glu Asp Asp Val Arg Asp Asn Ile Leu Lys Tyr Asp 
    770                 775                 780                 


Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp Tyr Asp Leu Ser Gln Leu 
785                 790                 795                 800 


Gln Gln Pro Glu Ala Met Gly His Val Pro Ser Lys Ala Pro Gly Val 
                805                 810                 815     


Arg Arg Val Asp Glu Arg Pro Val Gly Ala Glu Pro Gln Tyr Pro Ile 
            820                 825                 830         


Arg Pro Met Val Pro His Pro Gly Asp Ile Gly Asp Phe Ile Asn Glu 
        835                 840                 845             


Gly Leu Arg Ala Ala Asp Asn Asp Pro Thr Ala Pro Pro Tyr Asp Ser 
    850                 855                 860                 


Leu Leu Val Phe Asp Tyr Glu Gly Ser Gly Ser Thr Ala Gly Ser Val 
865                 870                 875                 880 


Ser Ser Leu Asn Ser Ser Ser Ser Gly Asp Gln Asp Tyr Asp Tyr Leu 
                885                 890                 895     


Asn Asp Trp Gly Pro Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly 
            900                 905                 910         


Gly Glu Glu Asp 
        915     


<210>  2475
<211>  784
<212>  PRT
<213>  Homo sapiens

<400>  2475

Met Gln Arg Leu Met Met Leu Leu Ala Thr Ser Gly Ala Cys Leu Gly 
1               5                   10                  15      


Leu Leu Ala Val Ala Ala Val Ala Ala Ala Gly Ala Asn Pro Ala Gln 
            20                  25                  30          


Arg Asp Thr His Ser Leu Leu Pro Thr His Arg Arg Gln Lys Arg Asp 
        35                  40                  45              


Trp Ile Trp Asn Gln Met His Ile Asp Glu Glu Lys Asn Thr Ser Leu 
    50                  55                  60                  


Pro His His Val Gly Lys Ile Lys Ser Ser Val Ser Arg Lys Asn Ala 
65                  70                  75                  80  


Lys Tyr Leu Leu Lys Gly Glu Tyr Val Gly Lys Val Phe Arg Val Asp 
                85                  90                  95      


Ala Glu Thr Gly Asp Val Phe Ala Ile Glu Arg Leu Asp Arg Glu Asn 
            100                 105                 110         


Ile Ser Glu Tyr His Leu Thr Ala Val Ile Val Asp Lys Asp Thr Gly 
        115                 120                 125             


Glu Asn Leu Glu Thr Pro Ser Ser Phe Thr Ile Lys Val His Asp Val 
    130                 135                 140                 


Asn Asp Asn Trp Pro Val Phe Thr His Arg Leu Phe Asn Ala Ser Val 
145                 150                 155                 160 


Pro Glu Ser Ser Ala Val Gly Thr Ser Val Ile Ser Val Thr Ala Val 
                165                 170                 175     


Asp Ala Asp Asp Pro Thr Val Gly Asp His Ala Ser Val Met Tyr Gln 
            180                 185                 190         


Ile Leu Lys Gly Lys Glu Tyr Phe Ala Ile Asp Asn Ser Gly Arg Ile 
        195                 200                 205             


Ile Thr Ile Thr Lys Ser Leu Asp Arg Glu Lys Gln Ala Arg Tyr Glu 
    210                 215                 220                 


Ile Val Val Glu Ala Arg Asp Ala Gln Gly Leu Arg Gly Asp Ser Gly 
225                 230                 235                 240 


Thr Ala Thr Val Leu Val Thr Leu Gln Asp Ile Asn Asp Asn Phe Pro 
                245                 250                 255     


Phe Phe Thr Gln Thr Lys Tyr Thr Phe Val Val Pro Glu Asp Thr Arg 
            260                 265                 270         


Val Gly Thr Ser Val Gly Ser Leu Phe Val Glu Asp Pro Asp Glu Pro 
        275                 280                 285             


Gln Asn Arg Met Thr Lys Tyr Ser Ile Leu Arg Gly Asp Tyr Gln Asp 
    290                 295                 300                 


Ala Phe Thr Ile Glu Thr Asn Pro Ala His Asn Glu Gly Ile Ile Lys 
305                 310                 315                 320 


Pro Met Lys Pro Leu Asp Tyr Glu Tyr Ile Gln Gln Tyr Ser Phe Ile 
                325                 330                 335     


Val Glu Ala Thr Asp Pro Thr Ile Asp Leu Arg Tyr Met Ser Pro Pro 
            340                 345                 350         


Ala Gly Asn Arg Ala Gln Val Ile Ile Asn Ile Thr Asp Val Asp Glu 
        355                 360                 365             


Pro Pro Ile Phe Gln Gln Pro Phe Tyr His Phe Gln Leu Lys Glu Asn 
    370                 375                 380                 


Gln Lys Lys Pro Leu Ile Gly Thr Val Leu Ala Met Asp Pro Asp Ala 
385                 390                 395                 400 


Ala Arg His Ser Ile Gly Tyr Ser Ile Arg Arg Thr Ser Asp Lys Gly 
                405                 410                 415     


Gln Phe Phe Arg Val Thr Lys Lys Gly Asp Ile Tyr Asn Glu Lys Glu 
            420                 425                 430         


Leu Asp Arg Glu Val Tyr Pro Trp Tyr Asn Leu Thr Val Glu Ala Lys 
        435                 440                 445             


Glu Leu Asp Ser Thr Gly Thr Pro Thr Gly Lys Glu Ser Ile Val Gln 
    450                 455                 460                 


Val His Ile Glu Val Leu Asp Glu Asn Asp Asn Ala Pro Glu Phe Ala 
465                 470                 475                 480 


Lys Pro Tyr Gln Pro Lys Val Cys Glu Asn Ala Val His Gly Gln Leu 
                485                 490                 495     


Val Leu Gln Ile Ser Ala Ile Asp Lys Asp Ile Thr Pro Arg Asn Val 
            500                 505                 510         


Lys Phe Lys Phe Ile Leu Asn Thr Glu Asn Asn Phe Thr Leu Thr Asp 
        515                 520                 525             


Asn His Asp Asn Thr Ala Asn Ile Thr Val Lys Tyr Gly Gln Phe Asp 
    530                 535                 540                 


Arg Glu His Thr Lys Val His Phe Leu Pro Val Val Ile Ser Asp Asn 
545                 550                 555                 560 


Gly Met Pro Ser Arg Thr Gly Thr Ser Thr Leu Thr Val Ala Val Cys 
                565                 570                 575     


Lys Cys Asn Glu Gln Gly Glu Phe Thr Phe Cys Glu Asp Met Ala Ala 
            580                 585                 590         


Gln Val Gly Val Ser Ile Gln Ala Val Val Ala Ile Leu Leu Cys Ile 
        595                 600                 605             


Leu Thr Ile Thr Val Ile Thr Leu Leu Ile Phe Leu Arg Arg Arg Leu 
    610                 615                 620                 


Arg Lys Gln Ala Arg Ala His Gly Lys Ser Val Pro Glu Ile His Glu 
625                 630                 635                 640 


Gln Leu Val Thr Tyr Asp Glu Glu Gly Gly Gly Glu Met Asp Thr Thr 
                645                 650                 655     


Ser Tyr Asp Val Ser Val Leu Asn Ser Val Arg Arg Gly Gly Ala Lys 
            660                 665                 670         


Pro Pro Arg Pro Ala Leu Asp Ala Arg Pro Ser Leu Tyr Ala Gln Val 
        675                 680                 685             


Gln Lys Pro Pro Arg His Ala Pro Gly Ala His Gly Gly Pro Gly Glu 
    690                 695                 700                 


Met Ala Ala Met Ile Glu Val Lys Lys Asp Glu Ala Asp His Asp Gly 
705                 710                 715                 720 


Asp Gly Pro Pro Tyr Asp Thr Leu His Ile Tyr Gly Tyr Glu Gly Ser 
                725                 730                 735     


Glu Ser Ile Ala Glu Ser Leu Ser Ser Leu Gly Thr Asp Ser Ser Asp 
            740                 745                 750         


Ser Asp Val Asp Tyr Asp Phe Leu Asn Asp Trp Gly Pro Arg Phe Lys 
        755                 760                 765             


Met Leu Ala Glu Leu Tyr Gly Ser Asp Pro Arg Glu Glu Leu Leu Tyr 
    770                 775                 780                 


<210>  2476
<211>  799
<212>  PRT
<213>  Homo sapiens

<400>  2476

Met Pro Glu Arg Leu Ala Glu Met Leu Leu Asp Leu Trp Thr Pro Leu 
1               5                   10                  15      


Ile Ile Leu Trp Ile Thr Leu Pro Pro Cys Ile Tyr Met Ala Pro Met 
            20                  25                  30          


Asn Gln Ser Gln Val Leu Met Ser Gly Ser Pro Leu Glu Leu Asn Ser 
        35                  40                  45              


Leu Gly Glu Glu Gln Arg Ile Leu Asn Arg Ser Lys Arg Gly Trp Val 
    50                  55                  60                  


Trp Asn Gln Met Phe Val Leu Glu Glu Phe Ser Gly Pro Glu Pro Ile 
65                  70                  75                  80  


Leu Val Gly Arg Leu His Thr Asp Leu Asp Pro Gly Ser Lys Lys Ile 
                85                  90                  95      


Lys Tyr Ile Leu Ser Gly Asp Gly Ala Gly Thr Ile Phe Gln Ile Asn 
            100                 105                 110         


Asp Val Thr Gly Asp Ile His Ala Ile Lys Arg Leu Asp Arg Glu Glu 
        115                 120                 125             


Lys Ala Glu Tyr Thr Leu Thr Ala Gln Ala Val Asp Trp Glu Thr Ser 
    130                 135                 140                 


Lys Pro Leu Glu Pro Pro Ser Glu Phe Ile Ile Lys Val Gln Asp Ile 
145                 150                 155                 160 


Asn Asp Asn Ala Pro Glu Phe Leu Asn Gly Pro Tyr His Ala Thr Val 
                165                 170                 175     


Pro Glu Met Ser Ile Leu Gly Thr Ser Val Thr Asn Val Thr Ala Thr 
            180                 185                 190         


Asp Ala Asp Asp Pro Val Tyr Gly Asn Ser Ala Lys Leu Val Tyr Ser 
        195                 200                 205             


Ile Leu Glu Gly Gln Pro Tyr Phe Ser Ile Glu Pro Glu Thr Ala Ile 
    210                 215                 220                 


Ile Lys Thr Ala Leu Pro Asn Met Asp Arg Glu Ala Lys Glu Glu Tyr 
225                 230                 235                 240 


Leu Val Val Ile Gln Ala Lys Asp Met Gly Gly His Ser Gly Gly Leu 
                245                 250                 255     


Ser Gly Thr Thr Thr Leu Thr Val Thr Leu Thr Asp Val Asn Asp Asn 
            260                 265                 270         


Pro Pro Lys Phe Ala Gln Ser Leu Tyr His Phe Ser Val Pro Glu Asp 
        275                 280                 285             


Val Val Leu Gly Thr Ala Ile Gly Arg Val Lys Ala Asn Asp Gln Asp 
    290                 295                 300                 


Ile Gly Glu Asn Ala Gln Ser Ser Tyr Asp Ile Ile Asp Gly Asp Gly 
305                 310                 315                 320 


Thr Ala Leu Phe Glu Ile Thr Ser Asp Ala Gln Ala Gln Asp Gly Ile 
                325                 330                 335     


Ile Arg Leu Arg Lys Pro Leu Asp Phe Glu Thr Lys Lys Ser Tyr Thr 
            340                 345                 350         


Leu Lys Val Glu Ala Ala Asn Val His Ile Asp Pro Arg Phe Ser Gly 
        355                 360                 365             


Arg Gly Pro Phe Lys Asp Thr Ala Thr Val Lys Ile Val Val Glu Asp 
    370                 375                 380                 


Ala Asp Glu Pro Pro Val Phe Ser Ser Pro Thr Tyr Leu Leu Glu Val 
385                 390                 395                 400 


His Glu Asn Ala Ala Leu Asn Ser Val Ile Gly Gln Val Thr Ala Arg 
                405                 410                 415     


Asp Pro Asp Ile Thr Ser Ser Pro Ile Arg Phe Ser Ile Asp Arg His 
            420                 425                 430         


Thr Asp Leu Glu Arg Gln Phe Asn Ile Asn Ala Asp Asp Gly Lys Ile 
        435                 440                 445             


Thr Leu Ala Thr Pro Leu Asp Arg Glu Leu Ser Val Trp His Asn Ile 
    450                 455                 460                 


Thr Ile Ile Ala Thr Glu Ile Arg Asn His Ser Gln Ile Ser Arg Val 
465                 470                 475                 480 


Pro Val Ala Ile Lys Val Leu Asp Val Asn Asp Asn Ala Pro Glu Phe 
                485                 490                 495     


Ala Ser Glu Tyr Glu Ala Phe Leu Cys Glu Asn Gly Lys Pro Gly Gln 
            500                 505                 510         


Val Ile Gln Thr Val Ser Ala Met Asp Lys Asp Asp Pro Lys Asn Gly 
        515                 520                 525             


His Tyr Phe Leu Tyr Ser Leu Leu Pro Glu Met Val Asn Asn Pro Asn 
    530                 535                 540                 


Phe Thr Ile Lys Lys Asn Glu Asp Asn Ser Leu Ser Ile Leu Ala Lys 
545                 550                 555                 560 


His Asn Gly Phe Asn Arg Gln Lys Gln Glu Val Tyr Leu Leu Pro Ile 
                565                 570                 575     


Ile Ile Ser Asp Ser Gly Asn Pro Pro Leu Ser Ser Thr Ser Thr Leu 
            580                 585                 590         


Thr Ile Arg Val Cys Gly Cys Ser Asn Asp Gly Val Val Gln Ser Cys 
        595                 600                 605             


Asn Val Glu Ala Tyr Val Leu Pro Ile Gly Leu Ser Met Gly Ala Leu 
    610                 615                 620                 


Ile Ala Ile Leu Ala Cys Ile Ile Leu Leu Leu Val Ile Val Val Leu 
625                 630                 635                 640 


Phe Val Thr Leu Arg Arg His Lys Asn Glu Pro Leu Ile Ile Lys Asp 
                645                 650                 655     


Asp Glu Asp Val Arg Glu Asn Ile Ile Arg Tyr Asp Asp Glu Gly Gly 
            660                 665                 670         


Gly Glu Glu Asp Thr Glu Ala Phe Asp Ile Ala Thr Leu Gln Asn Pro 
        675                 680                 685             


Asp Gly Ile Asn Gly Phe Leu Pro Arg Lys Asp Ile Lys Pro Asp Leu 
    690                 695                 700                 


Gln Phe Met Pro Arg Gln Gly Leu Ala Pro Val Pro Asn Gly Val Asp 
705                 710                 715                 720 


Val Asp Glu Phe Ile Asn Val Arg Leu His Glu Ala Asp Asn Asp Pro 
                725                 730                 735     


Thr Ala Pro Pro Tyr Asp Ser Ile Gln Ile Tyr Gly Tyr Glu Gly Arg 
            740                 745                 750         


Gly Ser Val Ala Gly Ser Leu Ser Ser Leu Glu Ser Thr Thr Ser Asp 
        755                 760                 765             


Ser Asp Gln Asn Phe Asp Tyr Leu Ser Asp Trp Gly Pro Arg Phe Lys 
    770                 775                 780                 


Arg Leu Gly Glu Leu Tyr Ser Val Gly Glu Ser Asp Lys Glu Thr 
785                 790                 795                 


<210>  2477
<211>  796
<212>  PRT
<213>  Homo sapiens

<400>  2477

Met Lys Glu Asn Tyr Cys Leu Gln Ala Ala Leu Val Cys Leu Gly Met 
1               5                   10                  15      


Leu Cys His Ser His Ala Phe Ala Pro Glu Arg Arg Gly His Leu Arg 
            20                  25                  30          


Pro Ser Phe His Gly His His Glu Lys Gly Lys Glu Gly Gln Val Leu 
        35                  40                  45              


Gln Arg Ser Lys Arg Gly Trp Val Trp Asn Gln Phe Phe Val Ile Glu 
    50                  55                  60                  


Glu Tyr Thr Gly Pro Asp Pro Val Leu Val Gly Arg Leu His Ser Asp 
65                  70                  75                  80  


Ile Asp Ser Gly Asp Gly Asn Ile Lys Tyr Ile Leu Ser Gly Glu Gly 
                85                  90                  95      


Ala Gly Thr Ile Phe Val Ile Asp Asp Lys Ser Gly Asn Ile His Ala 
            100                 105                 110         


Thr Lys Thr Leu Asp Arg Glu Glu Arg Ala Gln Tyr Thr Leu Met Ala 
        115                 120                 125             


Gln Ala Val Asp Arg Asp Thr Asn Arg Pro Leu Glu Pro Pro Ser Glu 
    130                 135                 140                 


Phe Ile Val Lys Val Gln Asp Ile Asn Asp Asn Pro Pro Glu Phe Leu 
145                 150                 155                 160 


His Glu Thr Tyr His Ala Asn Val Pro Glu Arg Ser Asn Val Gly Thr 
                165                 170                 175     


Ser Val Ile Gln Val Thr Ala Ser Asp Ala Asp Asp Pro Thr Tyr Gly 
            180                 185                 190         


Asn Ser Ala Lys Leu Val Tyr Ser Ile Leu Glu Gly Gln Pro Tyr Phe 
        195                 200                 205             


Ser Val Glu Ala Gln Thr Gly Ile Ile Arg Thr Ala Leu Pro Asn Met 
    210                 215                 220                 


Asp Arg Glu Ala Lys Glu Glu Tyr His Val Val Ile Gln Ala Lys Asp 
225                 230                 235                 240 


Met Gly Gly His Met Gly Gly Leu Ser Gly Thr Thr Lys Val Thr Ile 
                245                 250                 255     


Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Lys Phe Pro Gln Ser Val 
            260                 265                 270         


Tyr Gln Met Ser Val Ser Glu Ala Ala Val Pro Gly Glu Glu Val Gly 
        275                 280                 285             


Arg Val Lys Ala Lys Asp Pro Asp Ile Gly Glu Asn Gly Leu Val Thr 
    290                 295                 300                 


Tyr Asn Ile Val Asp Gly Asp Gly Met Glu Ser Phe Glu Ile Thr Thr 
305                 310                 315                 320 


Asp Tyr Glu Thr Gln Glu Gly Val Ile Lys Leu Lys Lys Pro Val Asp 
                325                 330                 335     


Phe Glu Thr Lys Arg Ala Tyr Ser Leu Lys Val Glu Ala Ala Asn Val 
            340                 345                 350         


His Ile Asp Pro Lys Phe Ile Ser Asn Gly Pro Phe Lys Asp Thr Val 
        355                 360                 365             


Thr Val Lys Ile Ser Val Glu Asp Ala Asp Glu Pro Pro Met Phe Leu 
    370                 375                 380                 


Ala Pro Ser Tyr Ile His Glu Val Gln Glu Asn Ala Ala Ala Gly Thr 
385                 390                 395                 400 


Val Val Gly Arg Val His Ala Lys Asp Pro Asp Ala Ala Asn Ser Pro 
                405                 410                 415     


Ile Arg Tyr Ser Ile Asp Arg His Thr Asp Leu Asp Arg Phe Phe Thr 
            420                 425                 430         


Ile Asn Pro Glu Asp Gly Phe Ile Lys Thr Thr Lys Pro Leu Asp Arg 
        435                 440                 445             


Glu Glu Thr Ala Trp Leu Asn Ile Thr Val Phe Ala Ala Glu Ile His 
    450                 455                 460                 


Asn Arg His Gln Glu Ala Lys Val Pro Val Ala Ile Arg Val Leu Asp 
465                 470                 475                 480 


Val Asn Asp Asn Ala Pro Lys Phe Ala Ala Pro Tyr Glu Gly Phe Ile 
                485                 490                 495     


Cys Glu Ser Asp Gln Thr Lys Pro Leu Ser Asn Gln Pro Ile Val Thr 
            500                 505                 510         


Ile Ser Ala Asp Asp Lys Asp Asp Thr Ala Asn Gly Pro Arg Phe Ile 
        515                 520                 525             


Phe Ser Leu Pro Pro Glu Ile Ile His Asn Pro Asn Phe Thr Val Arg 
    530                 535                 540                 


Asp Asn Arg Asp Asn Thr Ala Gly Val Tyr Ala Arg Arg Gly Gly Phe 
545                 550                 555                 560 


Ser Arg Gln Lys Gln Asp Leu Tyr Leu Leu Pro Ile Val Ile Ser Asp 
                565                 570                 575     


Gly Gly Ile Pro Pro Met Ser Ser Thr Asn Thr Leu Thr Ile Lys Val 
            580                 585                 590         


Cys Gly Cys Asp Val Asn Gly Ala Leu Leu Ser Cys Asn Ala Glu Ala 
        595                 600                 605             


Tyr Ile Leu Asn Ala Gly Leu Ser Thr Gly Ala Leu Ile Ala Ile Leu 
    610                 615                 620                 


Ala Cys Ile Val Ile Leu Leu Val Ile Val Val Leu Phe Val Thr Leu 
625                 630                 635                 640 


Arg Arg Gln Lys Lys Glu Pro Leu Ile Val Phe Glu Glu Glu Asp Val 
                645                 650                 655     


Arg Glu Asn Ile Ile Thr Tyr Asp Asp Glu Gly Gly Gly Glu Glu Asp 
            660                 665                 670         


Thr Glu Ala Phe Asp Ile Ala Thr Leu Gln Asn Pro Asp Gly Ile Asn 
        675                 680                 685             


Gly Phe Ile Pro Arg Lys Asp Ile Lys Pro Glu Tyr Gln Tyr Met Pro 
    690                 695                 700                 


Arg Pro Gly Leu Arg Pro Ala Pro Asn Ser Val Asp Val Asp Asp Phe 
705                 710                 715                 720 


Ile Asn Thr Arg Ile Gln Glu Ala Asp Asn Asp Pro Thr Ala Pro Pro 
                725                 730                 735     


Tyr Asp Ser Ile Gln Ile Tyr Gly Tyr Glu Gly Arg Gly Ser Val Ala 
            740                 745                 750         


Gly Ser Leu Ser Ser Leu Glu Ser Ala Thr Thr Asp Ser Asp Leu Asp 
        755                 760                 765             


Tyr Asp Tyr Leu Gln Asn Trp Gly Pro Arg Phe Lys Lys Leu Ala Asp 
    770                 775                 780                 


Leu Tyr Gly Ser Lys Asp Thr Phe Asp Asp Asp Ser 
785                 790                 795     


<210>  2478
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  2478

Met Lys Arg Phe Leu Phe Leu Leu Leu Thr Ile Ser Leu Leu Val Met 
1               5                   10                  15      


Val Gln Ile Gln Thr Gly Leu Ser Gly Gln Asn Asp Thr Ser Gln Thr 
            20                  25                  30          


Ser Ser Pro Ser Ala Ser Ser Asn Ile Ser Gly Gly Ile Phe Leu Phe 
        35                  40                  45              


Phe Val Ala Asn Ala Ile Ile His Leu Phe Cys Phe Ser 
    50                  55                  60      


<210>  2479
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  2479

Met Gly Pro Pro Ser Ala Ser Pro His Arg Glu Cys Ile Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Asn Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Met Pro Leu Ser Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Ala Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Thr Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Ile Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Gln Glu Asn 
    130                 135                 140                 


Ala Pro Gly Leu Pro Val Gly Ala Val Ala Gly Ile Val Thr Gly Val 
145                 150                 155                 160 


Leu Val Gly Val Ala Leu Val Ala Ala Leu Val Cys Phe Leu Leu Leu 
                165                 170                 175     


Ala Lys Thr Gly Arg Thr Ser Ile Gln Arg Asp Leu Lys Glu Gln Gln 
            180                 185                 190         


Pro Gln Ala Leu Ala Pro Gly Arg Gly Pro Ser His Ser Ser Ala Phe 
        195                 200                 205             


Ser Met Ser Pro Leu Ser Thr Ala Gln Ala Pro Leu Pro Asn Pro Arg 
    210                 215                 220                 


Thr Ala Ala Ser Ile Tyr Glu Glu Leu Leu Lys His Asp Thr Asn Ile 
225                 230                 235                 240 


Tyr Cys Arg Met Asp His Lys Ala Glu Val Ala Ser 
                245                 250         


<210>  2480
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  2480

Met Gly Pro Pro Ser Ala Ala Pro Arg Gly Gly His Arg Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Ile Thr Ala Ser Leu Leu Thr Phe Trp His Pro Pro Thr 
            20                  25                  30          


Thr Val Gln Phe Thr Ile Glu Ala Leu Pro Ser Ser Ala Ala Glu Gly 
        35                  40                  45              


Lys Asp Val Leu Leu Leu Ala Cys Asn Ile Ser Glu Thr Ile Gln Ala 
    50                  55                  60                  


Tyr Tyr Trp His Lys Gly Lys Thr Ala Glu Gly Ser Pro Leu Ile Ala 
65                  70                  75                  80  


Gly Tyr Ile Thr Asp Ile Gln Ala Asn Ile Pro Gly Ala Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Thr Val Tyr Pro Asn Gly Ser Leu Leu Phe Gln Asn Ile 
            100                 105                 110         


Thr Leu Glu Asp Ala Gly Ser Tyr Thr Leu Arg Thr Ile Asn Ala Ser 
        115                 120                 125             


Tyr Asp Ser Asp Gln Ala Thr Gly Gln Leu His Val His Gln Asn Asn 
    130                 135                 140                 


Val Pro Gly Leu Pro Val Gly Ala Val Ala Gly Ile Val Thr Gly Val 
145                 150                 155                 160 


Leu Val Gly Val Ala Leu Val Ala Ala Leu Val Cys Phe Leu Leu Leu 
                165                 170                 175     


Ser Arg Thr Gly Arg Ala Ser Ile Gln Arg Asp Leu Arg Glu Gln Pro 
            180                 185                 190         


Pro Pro Ala Ser Thr Pro Gly His Gly Pro Ser His Arg Ser Thr Phe 
        195                 200                 205             


Ser Ala Pro Leu Pro Ser Pro Arg Thr Ala Thr Pro Ile Tyr Glu Glu 
    210                 215                 220                 


Leu Leu Tyr Ser Asp Ala Asn Ile Tyr Cys Gln Ile Asp His Lys Ala 
225                 230                 235                 240 


Asp Val Val Ser 
                


<210>  2481
<211>  818
<212>  PRT
<213>  Homo sapiens

<400>  2481

Met Glu Ser Glu Gln Leu Phe His Arg Gly Tyr Tyr Arg Asn Ser Tyr 
1               5                   10                  15      


Asn Ser Ile Thr Ser Ala Ser Ser Asp Glu Glu Leu Leu Asp Gly Ala 
            20                  25                  30          


Gly Val Ile Met Asp Phe Gln Thr Ser Glu Asp Asp Asn Leu Leu Asp 
        35                  40                  45              


Gly Asp Thr Ala Val Gly Thr His Tyr Thr Met Thr Asn Gly Gly Ser 
    50                  55                  60                  


Ile Asn Ser Ser Thr His Leu Leu Asp Leu Leu Asp Glu Pro Ile Pro 
65                  70                  75                  80  


Gly Val Gly Thr Tyr Asp Asp Phe His Thr Ile Asp Trp Val Arg Glu 
                85                  90                  95      


Lys Cys Lys Asp Arg Glu Arg His Arg Arg Ile Asn Ser Lys Lys Lys 
            100                 105                 110         


Glu Ser Ala Trp Glu Met Thr Lys Ser Leu Tyr Asp Ala Trp Ser Gly 
        115                 120                 125             


Trp Leu Val Val Thr Leu Thr Gly Leu Ala Ser Gly Ala Leu Ala Gly 
    130                 135                 140                 


Leu Ile Asp Ile Ala Ala Asp Trp Met Thr Asp Leu Lys Glu Gly Ile 
145                 150                 155                 160 


Cys Leu Ser Ala Leu Trp Tyr Asn His Glu Gln Cys Cys Trp Gly Ser 
                165                 170                 175     


Asn Glu Thr Thr Phe Glu Glu Arg Asp Lys Cys Pro Gln Trp Lys Thr 
            180                 185                 190         


Trp Ala Glu Leu Ile Ile Gly Gln Ala Glu Gly Pro Gly Ser Tyr Ile 
        195                 200                 205             


Met Asn Tyr Ile Met Tyr Ile Phe Trp Ala Leu Ser Phe Ala Phe Leu 
    210                 215                 220                 


Ala Val Ser Leu Val Lys Val Phe Ala Pro Tyr Ala Cys Gly Ser Gly 
225                 230                 235                 240 


Ile Pro Glu Ile Lys Thr Ile Leu Ser Gly Phe Ile Ile Arg Gly Tyr 
                245                 250                 255     


Leu Gly Lys Trp Thr Leu Met Ile Lys Thr Ile Thr Leu Val Leu Ala 
            260                 265                 270         


Val Ala Ser Gly Leu Ser Leu Gly Lys Glu Gly Pro Leu Val His Val 
        275                 280                 285             


Ala Cys Cys Cys Gly Asn Ile Phe Ser Tyr Leu Phe Pro Lys Tyr Ser 
    290                 295                 300                 


Thr Asn Glu Ala Lys Lys Arg Glu Val Leu Ser Ala Ala Ser Ala Ala 
305                 310                 315                 320 


Gly Val Ser Val Ala Phe Gly Ala Pro Ile Gly Gly Val Leu Phe Ser 
                325                 330                 335     


Leu Glu Glu Val Ser Tyr Tyr Phe Pro Leu Lys Thr Leu Trp Arg Ser 
            340                 345                 350         


Phe Phe Ala Ala Leu Val Ala Ala Phe Val Leu Arg Ser Ile Asn Pro 
        355                 360                 365             


Phe Gly Asn Ser Arg Leu Val Leu Phe Tyr Val Glu Tyr His Thr Pro 
    370                 375                 380                 


Trp Tyr Leu Phe Glu Leu Phe Pro Phe Ile Leu Leu Gly Val Phe Gly 
385                 390                 395                 400 


Gly Leu Trp Gly Ala Phe Phe Ile Arg Ala Asn Ile Ala Trp Cys Arg 
                405                 410                 415     


Arg Arg Lys Ser Thr Lys Phe Gly Lys Tyr Pro Val Leu Glu Val Ile 
            420                 425                 430         


Ile Val Ala Ala Ile Thr Ala Val Ile Ala Phe Pro Asn Pro Tyr Thr 
        435                 440                 445             


Arg Leu Asn Thr Ser Glu Leu Ile Lys Glu Leu Phe Thr Asp Cys Gly 
    450                 455                 460                 


Pro Leu Glu Ser Ser Ser Leu Cys Asp Tyr Arg Asn Asp Met Asn Ala 
465                 470                 475                 480 


Ser Lys Ile Val Asp Asp Ile Pro Asp Arg Pro Ala Gly Ile Gly Val 
                485                 490                 495     


Tyr Ser Ala Ile Trp Gln Leu Cys Leu Ala Leu Ile Phe Lys Ile Ile 
            500                 505                 510         


Met Thr Val Phe Thr Phe Gly Ile Lys Val Pro Ser Gly Leu Phe Ile 
        515                 520                 525             


Pro Ser Met Ala Ile Gly Ala Ile Ala Gly Arg Ile Val Gly Ile Ala 
    530                 535                 540                 


Val Glu Gln Leu Ala Tyr Tyr His His Asp Trp Phe Ile Phe Lys Glu 
545                 550                 555                 560 


Trp Cys Glu Val Gly Ala Asp Cys Ile Thr Pro Gly Leu Tyr Ala Met 
                565                 570                 575     


Val Gly Ala Ala Ala Cys Leu Gly Gly Val Thr Arg Met Thr Val Ser 
            580                 585                 590         


Leu Val Val Ile Val Phe Glu Leu Thr Gly Gly Leu Glu Tyr Ile Val 
        595                 600                 605             


Pro Leu Met Ala Ala Val Met Thr Ser Lys Trp Val Gly Asp Ala Phe 
    610                 615                 620                 


Gly Arg Glu Gly Ile Tyr Glu Ala His Ile Arg Leu Asn Gly Tyr Pro 
625                 630                 635                 640 


Phe Leu Asp Ala Lys Glu Glu Phe Thr His Thr Thr Leu Ala Ala Asp 
                645                 650                 655     


Val Met Arg Pro Arg Arg Asn Asp Pro Pro Leu Ala Val Leu Thr Gln 
            660                 665                 670         


Asp Asn Met Thr Val Asp Asp Ile Glu Asn Met Ile Asn Glu Thr Ser 
        675                 680                 685             


Tyr Asn Gly Phe Pro Val Ile Met Ser Lys Glu Ser Gln Arg Leu Val 
    690                 695                 700                 


Gly Phe Ala Leu Arg Arg Asp Leu Thr Ile Ala Ile Glu Ser Ala Arg 
705                 710                 715                 720 


Lys Lys Gln Glu Gly Ile Val Gly Ser Ser Arg Val Cys Phe Ala Gln 
                725                 730                 735     


His Thr Pro Ser Leu Pro Ala Glu Ser Pro Arg Pro Leu Lys Leu Arg 
            740                 745                 750         


Ser Ile Leu Asp Met Ser Pro Phe Thr Val Thr Asp His Thr Pro Met 
        755                 760                 765             


Glu Ile Val Val Asp Ile Phe Arg Lys Leu Gly Leu Arg Gln Cys Leu 
    770                 775                 780                 


Val Thr His Asn Gly Arg Leu Leu Gly Ile Ile Thr Lys Lys Asp Ile 
785                 790                 795                 800 


Leu Arg His Met Ala Gln Thr Ala Asn Gln Asp Pro Ala Ser Ile Met 
                805                 810                 815     


Phe Asn 
        


<210>  2482
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  2482

Met Val Asn Ala Gly Ala Met Ser Gly Ser Gly Asn Leu Met Asp Phe 
1               5                   10                  15      


Leu Asp Glu Pro Phe Pro Asp Val Gly Thr Tyr Glu Asp Phe His Thr 
            20                  25                  30          


Ile Asp Trp Leu Arg Glu Lys Ser Arg Asp Thr Asp Arg His Arg Lys 
        35                  40                  45              


Ile Thr Ser Lys Ser Lys Glu Ser Ile Trp Glu Phe Ile Lys Ser Leu 
    50                  55                  60                  


Leu Asp Ala Trp Ser Gly Trp Val Val Met Leu Leu Ile Gly Leu Leu 
65                  70                  75                  80  


Ala Gly Thr Leu Ala Gly Val Ile Asp Leu Ala Val Asp Trp Met Thr 
                85                  90                  95      


Asp Leu Lys Glu Gly Val Cys Leu Ser Ala Phe Trp Tyr Ser His Glu 
            100                 105                 110         


Gln Cys Cys Trp Thr Ser Asn Glu Thr Thr Phe Glu Asp Arg Asp Lys 
        115                 120                 125             


Cys Pro Leu Trp Gln Lys Trp Ser Glu Leu Leu Val Asn Gln Ser Glu 
    130                 135                 140                 


Gly Ala Ser Ala Tyr Ile Leu Asn Tyr Leu Met Tyr Ile Leu Trp Ala 
145                 150                 155                 160 


Leu Leu Phe Ala Phe Leu Ala Val Ser Leu Val Arg Val Phe Ala Pro 
                165                 170                 175     


Tyr Ala Cys Gly Ser Gly Ile Pro Glu Ile Lys Thr Ile Leu Ser Gly 
            180                 185                 190         


Phe Ile Ile Arg Gly Tyr Leu Gly Lys Trp Thr Leu Leu Ile Lys Thr 
        195                 200                 205             


Val Thr Leu Val Leu Val Val Ser Ser Gly Leu Ser Leu Gly Lys Glu 
    210                 215                 220                 


Gly Pro Leu Val His Val Ala Cys Cys Cys Gly Asn Phe Phe Ser Ser 
225                 230                 235                 240 


Leu Phe Ser Lys Tyr Ser Lys Asn Glu Gly Lys Arg Arg Glu Val Leu 
                245                 250                 255     


Ser Ala Ala Ala Ala Ala Gly Val Ser Val Ala Phe Gly Ala Pro Ile 
            260                 265                 270         


Gly Gly Val Leu Phe Ser Leu Glu Glu Val Ser Tyr Tyr Phe Pro Leu 
        275                 280                 285             


Lys Thr Leu Trp Arg Ser Phe Phe Ala Ala Leu Val Ala Ala Phe Thr 
    290                 295                 300                 


Leu Arg Ser Ile Asn Pro Phe Gly Asn Ser Arg Leu Val Leu Phe Tyr 
305                 310                 315                 320 


Val Glu Tyr His Thr Pro Trp Tyr Met Ala Glu Leu Phe Pro Phe Ile 
                325                 330                 335     


Leu Leu Gly Val Phe Gly Gly Leu Trp Gly Thr Leu Phe Ile Arg Cys 
            340                 345                 350         


Asn Ile Ala Trp Cys Arg Arg Arg Lys Thr Thr Arg Leu Gly Lys Tyr 
        355                 360                 365             


Pro Val Leu Glu Val Ile Val Val Thr Ala Ile Thr Ala Ile Ile Ala 
    370                 375                 380                 


Tyr Pro Asn Pro Tyr Thr Arg Gln Ser Thr Ser Glu Leu Ile Ser Glu 
385                 390                 395                 400 


Leu Phe Asn Asp Cys Gly Ala Leu Glu Ser Ser Gln Leu Cys Asp Tyr 
                405                 410                 415     


Ile Asn Asp Pro Asn Met Thr Arg Pro Val Asp Asp Ile Pro Asp Arg 
            420                 425                 430         


Pro Ala Gly Val Gly Val Tyr Thr Ala Met Trp Gln Leu Ala Leu Ala 
        435                 440                 445             


Leu Ile Phe Lys Ile Val Val Thr Ile Phe Thr Phe Gly Met Lys Ile 
    450                 455                 460                 


Pro Ser Gly Leu Phe Ile Pro Ser Met Ala Val Gly Ala Ile Ala Gly 
465                 470                 475                 480 


Arg Met Val Gly Ile Gly Val Glu Gln Leu Ala Tyr His His His Asp 
                485                 490                 495     


Trp Ile Ile Phe Arg Asn Trp Cys Arg Pro Gly Ala Asp Cys Val Thr 
            500                 505                 510         


Pro Gly Leu Tyr Ala Met Val Gly Ala Ala Ala Cys Leu Gly Gly Val 
        515                 520                 525             


Thr Arg Met Thr Val Ser Leu Val Val Ile Met Phe Glu Leu Thr Gly 
    530                 535                 540                 


Gly Leu Glu Tyr Ile Val Pro Leu Met Ala Ala Ala Val Thr Ser Lys 
545                 550                 555                 560 


Trp Val Ala Asp Ala Phe Gly Lys Glu Gly Ile Tyr Glu Ala His Ile 
                565                 570                 575     


His Leu Asn Gly Tyr Pro Phe Leu Asp Val Lys Asp Glu Phe Thr His 
            580                 585                 590         


Arg Thr Leu Ala Thr Asp Val Met Arg Pro Arg Arg Gly Glu Pro Pro 
        595                 600                 605             


Leu Ser Val Leu Thr Gln Asp Ser Met Thr Val Glu Asp Val Glu Thr 
    610                 615                 620                 


Leu Ile Lys Glu Thr Asp Tyr Asn Gly Phe Pro Val Val Val Ser Arg 
625                 630                 635                 640 


Asp Ser Glu Arg Leu Ile Gly Phe Ala Gln Arg Arg Glu Leu Ile Leu 
                645                 650                 655     


Ala Ile Lys Asn Ala Arg Gln Arg Gln Glu Gly Ile Val Ser Asn Ser 
            660                 665                 670         


Ile Met Tyr Phe Thr Glu Glu Pro Pro Glu Leu Pro Ala Asn Ser Pro 
        675                 680                 685             


His Pro Leu Lys Leu Arg Arg Ile Leu Asn Leu Ser Pro Phe Thr Val 
    690                 695                 700                 


Thr Asp His Thr Pro Met Glu Thr Val Val Asp Ile Phe Arg Lys Leu 
705                 710                 715                 720 


Gly Leu Arg Gln Cys Leu Val Thr Arg Ser Gly Arg Leu Leu Gly Ile 
                725                 730                 735     


Ile Thr Lys Lys Asp Val Leu Arg His Met Ala Gln Met Ala Asn Gln 
            740                 745                 750         


Asp Pro Glu Ser Ile Met Phe Asn 
        755                 760 


<210>  2483
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  2483

Met Glu Lys Ile Leu Ile Leu Leu Leu Val Ala Leu Ser Val Ala Tyr 
1               5                   10                  15      


Ala Ala Pro Gly Pro Arg Gly Ile Ile Ile Asn Leu Glu Asn Gly Glu 
            20                  25                  30          


Leu Cys Met Asn Ser Ala Gln Cys Lys Ser Asn Cys Cys Gln His Ser 
        35                  40                  45              


Ser Ala Leu Gly Leu Ala Arg Cys Thr Ser Met Ala Ser Glu Asn Ser 
    50                  55                  60                  


Glu Cys Ser Val Lys Thr Leu Tyr Gly Ile Tyr Tyr Lys Cys Pro Cys 
65                  70                  75                  80  


Glu Arg Gly Leu Thr Cys Glu Gly Asp Lys Thr Ile Val Gly Ser Ile 
                85                  90                  95      


Thr Asn Thr Asn Phe Gly Ile Cys His Asp Ala Gly Arg Ser Lys Gln 
            100                 105                 110         


<210>  2484
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  2484

Met Thr Thr Ser Leu Asp Thr Val Glu Thr Phe Gly Thr Thr Ser Tyr 
1               5                   10                  15      


Tyr Asp Asp Val Gly Leu Leu Cys Glu Lys Ala Asp Thr Arg Ala Leu 
            20                  25                  30          


Met Ala Gln Phe Val Pro Pro Leu Tyr Ser Leu Val Phe Thr Val Gly 
        35                  40                  45              


Leu Leu Gly Asn Val Val Val Val Met Ile Leu Ile Lys Tyr Arg Arg 
    50                  55                  60                  


Leu Arg Ile Met Thr Asn Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp 
65                  70                  75                  80  


Leu Leu Phe Leu Val Thr Leu Pro Phe Trp Ile His Tyr Val Arg Gly 
                85                  90                  95      


His Asn Trp Val Phe Gly His Gly Met Cys Lys Leu Leu Ser Gly Phe 
            100                 105                 110         


Tyr His Thr Gly Leu Tyr Ser Glu Ile Phe Phe Ile Ile Leu Leu Thr 
        115                 120                 125             


Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe Ala Leu Arg Ala 
    130                 135                 140                 


Arg Thr Val Thr Phe Gly Val Ile Thr Ser Ile Val Thr Trp Gly Leu 
145                 150                 155                 160 


Ala Val Leu Ala Ala Leu Pro Glu Phe Ile Phe Tyr Glu Thr Glu Glu 
                165                 170                 175     


Leu Phe Glu Glu Thr Leu Cys Ser Ala Leu Tyr Pro Glu Asp Thr Val 
            180                 185                 190         


Tyr Ser Trp Arg His Phe His Thr Leu Arg Met Thr Ile Phe Cys Leu 
        195                 200                 205             


Val Leu Pro Leu Leu Val Met Ala Ile Cys Tyr Thr Gly Ile Ile Lys 
    210                 215                 220                 


Thr Leu Leu Arg Cys Pro Ser Lys Lys Lys Tyr Lys Ala Ile Arg Leu 
225                 230                 235                 240 


Ile Phe Val Ile Met Ala Val Phe Phe Ile Phe Trp Thr Pro Tyr Asn 
                245                 250                 255     


Val Ala Ile Leu Leu Ser Ser Tyr Gln Ser Ile Leu Phe Gly Asn Asp 
            260                 265                 270         


Cys Glu Arg Ser Lys His Leu Asp Leu Val Met Leu Val Thr Glu Val 
        275                 280                 285             


Ile Ala Tyr Ser His Cys Cys Met Asn Pro Val Ile Tyr Ala Phe Val 
    290                 295                 300                 


Gly Glu Arg Phe Arg Lys Tyr Leu Arg His Phe Phe His Arg His Leu 
305                 310                 315                 320 


Leu Met His Leu Gly Arg Tyr Ile Pro Phe Leu Pro Ser Glu Lys Leu 
                325                 330                 335     


Glu Arg Thr Ser Ser Val Ser Pro Ser Thr Ala Glu Pro Glu Leu Ser 
            340                 345                 350         


Ile Val Phe 
        355 


<210>  2485
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  2485

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  2486
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  2486

Met Glu Glu Cys Trp Val Thr Glu Ile Ala Asn Gly Ser Lys Asp Gly 
1               5                   10                  15      


Leu Asp Ser Asn Pro Met Lys Asp Tyr Met Ile Leu Ser Gly Pro Gln 
            20                  25                  30          


Lys Thr Ala Val Ala Val Leu Cys Thr Leu Leu Gly Leu Leu Ser Ala 
        35                  40                  45              


Leu Glu Asn Val Ala Val Leu Tyr Leu Ile Leu Ser Ser His Gln Leu 
    50                  55                  60                  


Arg Arg Lys Pro Ser Tyr Leu Phe Ile Gly Ser Leu Ala Gly Ala Asp 
65                  70                  75                  80  


Phe Leu Ala Ser Val Val Phe Ala Cys Ser Phe Val Asn Phe His Val 
                85                  90                  95      


Phe His Gly Val Asp Ser Lys Ala Val Phe Leu Leu Lys Ile Gly Ser 
            100                 105                 110         


Val Thr Met Thr Phe Thr Ala Ser Val Gly Ser Leu Leu Leu Thr Ala 
        115                 120                 125             


Ile Asp Arg Tyr Leu Cys Leu Arg Tyr Pro Pro Ser Tyr Lys Ala Leu 
    130                 135                 140                 


Leu Thr Arg Gly Arg Ala Leu Val Thr Leu Gly Ile Met Trp Val Leu 
145                 150                 155                 160 


Ser Ala Leu Val Ser Tyr Leu Pro Leu Met Gly Trp Thr Cys Cys Pro 
                165                 170                 175     


Arg Pro Cys Ser Glu Leu Phe Pro Leu Ile Pro Asn Asp Tyr Leu Leu 
            180                 185                 190         


Ser Trp Leu Leu Phe Ile Ala Phe Leu Phe Ser Gly Ile Ile Tyr Thr 
        195                 200                 205             


Tyr Gly His Val Leu Trp Lys Ala His Gln His Val Ala Ser Leu Ser 
    210                 215                 220                 


Gly His Gln Asp Arg Gln Val Pro Gly Met Ala Arg Met Arg Leu Asp 
225                 230                 235                 240 


Val Arg Leu Ala Lys Thr Leu Gly Leu Val Leu Ala Val Leu Leu Ile 
                245                 250                 255     


Cys Trp Phe Pro Val Leu Ala Leu Met Ala His Ser Leu Ala Thr Thr 
            260                 265                 270         


Leu Ser Asp Gln Val Lys Lys Ala Phe Ala Phe Cys Ser Met Leu Cys 
        275                 280                 285             


Leu Ile Asn Ser Met Val Asn Pro Val Ile Tyr Ala Leu Arg Ser Gly 
    290                 295                 300                 


Glu Ile Arg Ser Ser Ala His His Cys Leu Ala His Trp Lys Lys Cys 
305                 310                 315                 320 


Val Arg Gly Leu Gly Ser Glu Ala Lys Glu Glu Ala Pro Arg Ser Ser 
                325                 330                 335     


Val Thr Glu Thr Glu Ala Asp Gly Lys Ile Thr Pro Trp Pro Asp Ser 
            340                 345                 350         


Arg Asp Leu Asp Leu Ser Asp Cys 
        355                 360 


<210>  2487
<211>  1018
<212>  PRT
<213>  Homo sapiens

<400>  2487

Met Lys Met Trp Leu Leu Val Ser His Leu Val Ile Ile Ser Ile Thr 
1               5                   10                  15      


Thr Cys Leu Ala Glu Phe Thr Trp Tyr Arg Arg Tyr Gly His Gly Val 
            20                  25                  30          


Ser Glu Glu Asp Lys Gly Phe Gly Pro Ile Phe Glu Glu Gln Pro Ile 
        35                  40                  45              


Asn Thr Ile Tyr Pro Glu Glu Ser Leu Glu Gly Lys Val Ser Leu Asn 
    50                  55                  60                  


Cys Arg Ala Arg Ala Ser Pro Phe Pro Val Tyr Lys Trp Arg Met Asn 
65                  70                  75                  80  


Asn Gly Asp Val Asp Leu Thr Ser Asp Arg Tyr Ser Met Val Gly Gly 
                85                  90                  95      


Asn Leu Val Ile Asn Asn Pro Asp Lys Gln Lys Asp Ala Gly Ile Tyr 
            100                 105                 110         


Tyr Cys Leu Ala Ser Asn Asn Tyr Gly Met Val Arg Ser Thr Glu Ala 
        115                 120                 125             


Thr Leu Ser Phe Gly Tyr Leu Asp Pro Phe Pro Pro Glu Glu Arg Pro 
    130                 135                 140                 


Glu Val Arg Val Lys Glu Gly Lys Gly Met Val Leu Leu Cys Asp Pro 
145                 150                 155                 160 


Pro Tyr His Phe Pro Asp Asp Leu Ser Tyr Arg Trp Leu Leu Asn Glu 
                165                 170                 175     


Phe Pro Val Phe Ile Thr Met Asp Lys Arg Arg Phe Val Ser Gln Thr 
            180                 185                 190         


Asn Gly Asn Leu Tyr Ile Ala Asn Val Glu Ala Ser Asp Lys Gly Asn 
        195                 200                 205             


Tyr Ser Cys Phe Val Ser Ser Pro Ser Ile Thr Lys Ser Val Phe Ser 
    210                 215                 220                 


Lys Phe Ile Pro Leu Ile Pro Ile Pro Glu Arg Thr Thr Lys Pro Tyr 
225                 230                 235                 240 


Pro Ala Asp Ile Val Val Gln Phe Lys Asp Val Tyr Ala Leu Met Gly 
                245                 250                 255     


Gln Asn Val Thr Leu Glu Cys Phe Ala Leu Gly Asn Pro Val Pro Asp 
            260                 265                 270         


Ile Arg Trp Arg Lys Val Leu Glu Pro Met Pro Ser Thr Ala Glu Ile 
        275                 280                 285             


Ser Thr Ser Gly Ala Val Leu Lys Ile Phe Asn Ile Gln Leu Glu Asp 
    290                 295                 300                 


Glu Gly Ile Tyr Glu Cys Glu Ala Glu Asn Ile Arg Gly Lys Asp Lys 
305                 310                 315                 320 


His Gln Ala Arg Ile Tyr Val Gln Ala Phe Pro Glu Trp Val Glu His 
                325                 330                 335     


Ile Asn Asp Thr Glu Val Asp Ile Gly Ser Asp Leu Tyr Trp Pro Cys 
            340                 345                 350         


Val Ala Thr Gly Lys Pro Ile Pro Thr Ile Arg Trp Leu Lys Asn Gly 
        355                 360                 365             


Tyr Ala Tyr His Lys Gly Glu Leu Arg Leu Tyr Asp Val Thr Phe Glu 
    370                 375                 380                 


Asn Ala Gly Met Tyr Gln Cys Ile Ala Glu Asn Thr Tyr Gly Ala Ile 
385                 390                 395                 400 


Tyr Ala Asn Ala Glu Leu Lys Ile Leu Ala Leu Ala Pro Thr Phe Glu 
                405                 410                 415     


Met Asn Pro Met Lys Lys Lys Ile Leu Ala Ala Lys Gly Gly Arg Val 
            420                 425                 430         


Ile Ile Glu Cys Lys Pro Lys Ala Ala Pro Lys Pro Lys Phe Ser Trp 
        435                 440                 445             


Ser Lys Gly Thr Glu Trp Leu Val Asn Ser Ser Arg Ile Leu Ile Trp 
    450                 455                 460                 


Glu Asp Gly Ser Leu Glu Ile Asn Asn Ile Thr Arg Asn Asp Gly Gly 
465                 470                 475                 480 


Ile Tyr Thr Cys Phe Ala Glu Asn Asn Arg Gly Lys Ala Asn Ser Thr 
                485                 490                 495     


Gly Thr Leu Val Ile Thr Asp Pro Thr Arg Ile Ile Leu Ala Pro Ile 
            500                 505                 510         


Asn Ala Asp Ile Thr Val Gly Glu Asn Ala Thr Met Gln Cys Ala Ala 
        515                 520                 525             


Ser Phe Asp Pro Ala Leu Asp Leu Thr Phe Val Trp Ser Phe Asn Gly 
    530                 535                 540                 


Tyr Val Ile Asp Phe Asn Lys Glu Asn Ile His Tyr Gln Arg Asn Phe 
545                 550                 555                 560 


Met Leu Asp Ser Asn Gly Glu Leu Leu Ile Arg Asn Ala Gln Leu Lys 
                565                 570                 575     


His Ala Gly Arg Tyr Thr Cys Thr Ala Gln Thr Ile Val Asp Asn Ser 
            580                 585                 590         


Ser Ala Ser Ala Asp Leu Val Val Arg Gly Pro Pro Gly Pro Pro Gly 
        595                 600                 605             


Gly Leu Arg Ile Glu Asp Ile Arg Ala Thr Ser Val Ala Leu Thr Trp 
    610                 615                 620                 


Ser Arg Gly Ser Asp Asn His Ser Pro Ile Ser Lys Tyr Thr Ile Gln 
625                 630                 635                 640 


Thr Lys Thr Ile Leu Ser Asp Asp Trp Lys Asp Ala Lys Thr Asp Pro 
                645                 650                 655     


Pro Ile Ile Glu Gly Asn Met Glu Ala Ala Arg Ala Val Asp Leu Ile 
            660                 665                 670         


Pro Trp Met Glu Tyr Glu Phe Arg Val Val Ala Thr Asn Thr Leu Gly 
        675                 680                 685             


Arg Gly Glu Pro Ser Ile Pro Ser Asn Arg Ile Lys Thr Asp Gly Ala 
    690                 695                 700                 


Ala Pro Asn Val Ala Pro Ser Asp Val Gly Gly Gly Gly Gly Arg Asn 
705                 710                 715                 720 


Arg Glu Leu Thr Ile Thr Trp Ala Pro Leu Ser Arg Glu Tyr His Tyr 
                725                 730                 735     


Gly Asn Asn Phe Gly Tyr Ile Val Ala Phe Lys Pro Phe Asp Gly Glu 
            740                 745                 750         


Glu Trp Lys Lys Val Thr Val Thr Asn Pro Asp Thr Gly Arg Tyr Val 
        755                 760                 765             


His Lys Asp Glu Thr Met Ser Pro Ser Thr Ala Phe Gln Val Lys Val 
    770                 775                 780                 


Lys Ala Phe Asn Asn Lys Gly Asp Gly Pro Tyr Ser Leu Val Ala Val 
785                 790                 795                 800 


Ile Asn Ser Ala Gln Asp Ala Pro Ser Glu Ala Pro Thr Glu Val Gly 
                805                 810                 815     


Val Lys Val Leu Ser Ser Ser Glu Ile Ser Val His Trp Glu His Val 
            820                 825                 830         


Leu Glu Lys Ile Val Glu Ser Tyr Gln Ile Arg Tyr Trp Ala Ala His 
        835                 840                 845             


Asp Lys Glu Glu Ala Ala Asn Arg Val Gln Val Thr Ser Gln Glu Tyr 
    850                 855                 860                 


Ser Ala Arg Leu Glu Asn Leu Leu Pro Asp Thr Gln Tyr Phe Ile Glu 
865                 870                 875                 880 


Val Gly Ala Cys Asn Ser Ala Gly Cys Gly Pro Pro Ser Asp Met Ile 
                885                 890                 895     


Glu Ala Phe Thr Lys Lys Ala Pro Pro Ser Gln Pro Pro Arg Ile Ile 
            900                 905                 910         


Ser Ser Val Arg Ser Gly Ser Arg Tyr Ile Ile Thr Trp Asp His Val 
        915                 920                 925             


Val Ala Leu Ser Asn Glu Ser Thr Val Thr Gly Tyr Lys Val Leu Tyr 
    930                 935                 940                 


Arg Pro Asp Gly Gln His Asp Gly Lys Leu Tyr Ser Thr His Lys His 
945                 950                 955                 960 


Ser Ile Glu Val Pro Ile Pro Arg Asp Gly Glu Tyr Val Val Glu Val 
                965                 970                 975     


Arg Ala His Ser Asp Gly Gly Asp Gly Val Val Ser Gln Val Lys Ile 
            980                 985                 990         


Ser Gly Ala Pro Thr Leu Ser Pro  Ser Leu Leu Gly Leu  Leu Leu Pro 
        995                 1000                 1005             


Ala Phe  Gly Ile Leu Val Tyr  Leu Glu Phe 
    1010                 1015             


<210>  2488
<211>  1712
<212>  PRT
<213>  Homo sapiens

<400>  2488

Met Gly Arg Asp Gln Arg Ala Val Ala Gly Pro Ala Leu Arg Arg Trp 
1               5                   10                  15      


Leu Leu Leu Gly Thr Val Thr Val Gly Phe Leu Ala Gln Ser Val Leu 
            20                  25                  30          


Ala Gly Val Lys Lys Phe Asp Val Pro Cys Gly Gly Arg Asp Cys Ser 
        35                  40                  45              


Gly Gly Cys Gln Cys Tyr Pro Glu Lys Gly Gly Arg Gly Gln Pro Gly 
    50                  55                  60                  


Pro Val Gly Pro Gln Gly Tyr Asn Gly Pro Pro Gly Leu Gln Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Gln Gly Arg Lys Gly Asp Lys Gly Glu Arg Gly Ala Pro 
                85                  90                  95      


Gly Val Thr Gly Pro Lys Gly Asp Val Gly Ala Arg Gly Val Ser Gly 
            100                 105                 110         


Phe Pro Gly Ala Asp Gly Ile Pro Gly His Pro Gly Gln Gly Gly Pro 
        115                 120                 125             


Arg Gly Arg Pro Gly Tyr Asp Gly Cys Asn Gly Thr Gln Gly Asp Ser 
    130                 135                 140                 


Gly Pro Gln Gly Pro Pro Gly Ser Glu Gly Phe Thr Gly Pro Pro Gly 
145                 150                 155                 160 


Pro Gln Gly Pro Lys Gly Gln Lys Gly Glu Pro Tyr Ala Leu Pro Lys 
                165                 170                 175     


Glu Glu Arg Asp Arg Tyr Arg Gly Glu Pro Gly Glu Pro Gly Leu Val 
            180                 185                 190         


Gly Phe Gln Gly Pro Pro Gly Arg Pro Gly His Val Gly Gln Met Gly 
        195                 200                 205             


Pro Val Gly Ala Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Pro 
    210                 215                 220                 


Lys Gly Gln Gln Gly Asn Arg Gly Leu Gly Phe Tyr Gly Val Lys Gly 
225                 230                 235                 240 


Glu Lys Gly Asp Val Gly Gln Pro Gly Pro Asn Gly Ile Pro Ser Asp 
                245                 250                 255     


Thr Leu His Pro Ile Ile Ala Pro Thr Gly Val Thr Phe His Pro Asp 
            260                 265                 270         


Gln Tyr Lys Gly Glu Lys Gly Ser Glu Gly Glu Pro Gly Ile Arg Gly 
        275                 280                 285             


Ile Ser Leu Lys Gly Glu Glu Gly Ile Met Gly Phe Pro Gly Leu Arg 
    290                 295                 300                 


Gly Tyr Pro Gly Leu Ser Gly Glu Lys Gly Ser Pro Gly Gln Lys Gly 
305                 310                 315                 320 


Ser Arg Gly Leu Asp Gly Tyr Gln Gly Pro Asp Gly Pro Arg Gly Pro 
                325                 330                 335     


Lys Gly Glu Ala Gly Asp Pro Gly Pro Pro Gly Leu Pro Ala Tyr Ser 
            340                 345                 350         


Pro His Pro Ser Leu Ala Lys Gly Ala Arg Gly Asp Pro Gly Phe Pro 
        355                 360                 365             


Gly Ala Gln Gly Glu Pro Gly Ser Gln Gly Glu Pro Gly Asp Pro Gly 
    370                 375                 380                 


Leu Pro Gly Pro Pro Gly Leu Ser Ile Gly Asp Gly Asp Gln Arg Arg 
385                 390                 395                 400 


Gly Leu Pro Gly Glu Met Gly Pro Lys Gly Phe Ile Gly Asp Pro Gly 
                405                 410                 415     


Ile Pro Ala Leu Tyr Gly Gly Pro Pro Gly Pro Asp Gly Lys Arg Gly 
            420                 425                 430         


Pro Pro Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Asp Gly Phe 
        435                 440                 445             


Leu Phe Gly Leu Lys Gly Ala Lys Gly Arg Ala Gly Phe Pro Gly Leu 
    450                 455                 460                 


Pro Gly Ser Pro Gly Ala Arg Gly Pro Lys Gly Trp Lys Gly Asp Ala 
465                 470                 475                 480 


Gly Glu Cys Arg Cys Thr Glu Gly Asp Glu Ala Ile Lys Gly Leu Pro 
                485                 490                 495     


Gly Leu Pro Gly Pro Lys Gly Phe Ala Gly Ile Asn Gly Glu Pro Gly 
            500                 505                 510         


Arg Lys Gly Asp Arg Gly Asp Pro Gly Gln His Gly Leu Pro Gly Phe 
        515                 520                 525             


Pro Gly Leu Lys Gly Val Pro Gly Asn Ile Gly Ala Pro Gly Pro Lys 
    530                 535                 540                 


Gly Ala Lys Gly Asp Ser Arg Thr Ile Thr Thr Lys Gly Glu Arg Gly 
545                 550                 555                 560 


Gln Pro Gly Val Pro Gly Val Pro Gly Met Lys Gly Asp Asp Gly Ser 
                565                 570                 575     


Pro Gly Arg Asp Gly Leu Asp Gly Phe Pro Gly Leu Pro Gly Pro Pro 
            580                 585                 590         


Gly Asp Gly Ile Lys Gly Pro Pro Gly Asp Pro Gly Tyr Pro Gly Ile 
        595                 600                 605             


Pro Gly Thr Lys Gly Thr Pro Gly Glu Met Gly Pro Pro Gly Leu Gly 
    610                 615                 620                 


Leu Pro Gly Leu Lys Gly Gln Arg Gly Phe Pro Gly Asp Ala Gly Leu 
625                 630                 635                 640 


Pro Gly Pro Pro Gly Phe Leu Gly Pro Pro Gly Pro Ala Gly Thr Pro 
                645                 650                 655     


Gly Gln Ile Asp Cys Asp Thr Asp Val Lys Arg Ala Val Gly Gly Asp 
            660                 665                 670         


Arg Gln Glu Ala Ile Gln Pro Gly Cys Ile Gly Gly Pro Lys Gly Leu 
        675                 680                 685             


Pro Gly Leu Pro Gly Pro Pro Gly Pro Thr Gly Ala Lys Gly Leu Arg 
    690                 695                 700                 


Gly Ile Pro Gly Phe Ala Gly Ala Asp Gly Gly Pro Gly Pro Arg Gly 
705                 710                 715                 720 


Leu Pro Gly Asp Ala Gly Arg Glu Gly Phe Pro Gly Pro Pro Gly Phe 
                725                 730                 735     


Ile Gly Pro Arg Gly Ser Lys Gly Ala Val Gly Leu Pro Gly Pro Asp 
            740                 745                 750         


Gly Ser Pro Gly Pro Ile Gly Leu Pro Gly Pro Asp Gly Pro Pro Gly 
        755                 760                 765             


Glu Arg Gly Leu Pro Gly Glu Val Leu Gly Ala Gln Pro Gly Pro Arg 
    770                 775                 780                 


Gly Asp Ala Gly Val Pro Gly Gln Pro Gly Leu Lys Gly Leu Pro Gly 
785                 790                 795                 800 


Asp Arg Gly Pro Pro Gly Phe Arg Gly Ser Gln Gly Met Pro Gly Met 
                805                 810                 815     


Pro Gly Leu Lys Gly Gln Pro Gly Leu Pro Gly Pro Ser Gly Gln Pro 
            820                 825                 830         


Gly Leu Tyr Gly Pro Pro Gly Leu His Gly Phe Pro Gly Ala Pro Gly 
        835                 840                 845             


Gln Glu Gly Pro Leu Gly Leu Pro Gly Ile Pro Gly Arg Glu Gly Leu 
    850                 855                 860                 


Pro Gly Asp Arg Gly Asp Pro Gly Asp Thr Gly Ala Pro Gly Pro Val 
865                 870                 875                 880 


Gly Met Lys Gly Leu Ser Gly Asp Arg Gly Asp Ala Gly Phe Thr Gly 
                885                 890                 895     


Glu Gln Gly His Pro Gly Ser Pro Gly Phe Lys Gly Ile Asp Gly Met 
            900                 905                 910         


Pro Gly Thr Pro Gly Leu Lys Gly Asp Arg Gly Ser Pro Gly Met Asp 
        915                 920                 925             


Gly Phe Gln Gly Met Pro Gly Leu Lys Gly Arg Pro Gly Phe Pro Gly 
    930                 935                 940                 


Ser Lys Gly Glu Ala Gly Phe Phe Gly Ile Pro Gly Leu Lys Gly Leu 
945                 950                 955                 960 


Ala Gly Glu Pro Gly Phe Lys Gly Ser Arg Gly Asp Pro Gly Pro Pro 
                965                 970                 975     


Gly Pro Pro Pro Val Ile Leu Pro Gly Met Lys Asp Ile Lys Gly Glu 
            980                 985                 990         


Lys Gly Asp Glu Gly Pro Met Gly  Leu Lys Gly Tyr Leu  Gly Ala Lys 
        995                 1000                 1005             


Gly Ile  Gln Gly Met Pro Gly  Ile Pro Gly Leu Ser  Gly Ile Pro 
    1010                 1015                 1020             


Gly Leu  Pro Gly Arg Pro Gly  His Ile Lys Gly Val  Lys Gly Asp 
    1025                 1030                 1035             


Ile Gly  Val Pro Gly Ile Pro  Gly Leu Pro Gly Phe  Pro Gly Val 
    1040                 1045                 1050             


Ala Gly  Pro Pro Gly Ile Thr  Gly Phe Pro Gly Phe  Ile Gly Ser 
    1055                 1060                 1065             


Arg Gly  Asp Lys Gly Ala Pro  Gly Arg Ala Gly Leu  Tyr Gly Glu 
    1070                 1075                 1080             


Ile Gly  Ala Thr Gly Asp Phe  Gly Asp Ile Gly Asp  Thr Ile Asn 
    1085                 1090                 1095             


Leu Pro  Gly Arg Pro Gly Leu  Lys Gly Glu Arg Gly  Thr Thr Gly 
    1100                 1105                 1110             


Ile Pro  Gly Leu Lys Gly Phe  Phe Gly Glu Lys Gly  Thr Glu Gly 
    1115                 1120                 1125             


Asp Ile  Gly Phe Pro Gly Ile  Thr Gly Val Thr Gly  Val Gln Gly 
    1130                 1135                 1140             


Pro Pro  Gly Leu Lys Gly Gln  Thr Gly Phe Pro Gly  Leu Thr Gly 
    1145                 1150                 1155             


Pro Pro  Gly Ser Gln Gly Glu  Leu Gly Arg Ile Gly  Leu Pro Gly 
    1160                 1165                 1170             


Gly Lys  Gly Asp Asp Gly Trp  Pro Gly Ala Pro Gly  Leu Pro Gly 
    1175                 1180                 1185             


Phe Pro  Gly Leu Arg Gly Ile  Arg Gly Leu His Gly  Leu Pro Gly 
    1190                 1195                 1200             


Thr Lys  Gly Phe Pro Gly Ser  Pro Gly Ser Asp Ile  His Gly Asp 
    1205                 1210                 1215             


Pro Gly  Phe Pro Gly Pro Pro  Gly Glu Arg Gly Asp  Pro Gly Glu 
    1220                 1225                 1230             


Ala Asn  Thr Leu Pro Gly Pro  Val Gly Val Pro Gly  Gln Lys Gly 
    1235                 1240                 1245             


Asp Gln  Gly Ala Pro Gly Glu  Arg Gly Pro Pro Gly  Ser Pro Gly 
    1250                 1255                 1260             


Leu Gln  Gly Phe Pro Gly Ile  Thr Pro Pro Ser Asn  Ile Ser Gly 
    1265                 1270                 1275             


Ala Pro  Gly Asp Lys Gly Ala  Pro Gly Ile Phe Gly  Leu Lys Gly 
    1280                 1285                 1290             


Tyr Arg  Gly Pro Pro Gly Pro  Pro Gly Ser Ala Ala  Leu Pro Gly 
    1295                 1300                 1305             


Ser Lys  Gly Asp Thr Gly Asn  Pro Gly Ala Pro Gly  Thr Pro Gly 
    1310                 1315                 1320             


Thr Lys  Gly Trp Ala Gly Asp  Ser Gly Pro Gln Gly  Arg Pro Gly 
    1325                 1330                 1335             


Val Phe  Gly Leu Pro Gly Glu  Lys Gly Pro Arg Gly  Glu Gln Gly 
    1340                 1345                 1350             


Phe Met  Gly Asn Thr Gly Pro  Thr Gly Ala Val Gly  Asp Arg Gly 
    1355                 1360                 1365             


Pro Lys  Gly Pro Lys Gly Asp  Pro Gly Phe Pro Gly  Ala Pro Gly 
    1370                 1375                 1380             


Thr Val  Gly Ala Pro Gly Ile  Ala Gly Ile Pro Gln  Lys Ile Ala 
    1385                 1390                 1395             


Val Gln  Pro Gly Thr Val Gly  Pro Gln Gly Arg Arg  Gly Pro Pro 
    1400                 1405                 1410             


Gly Ala  Pro Gly Glu Met Gly  Pro Gln Gly Pro Pro  Gly Glu Pro 
    1415                 1420                 1425             


Gly Phe  Arg Gly Ala Pro Gly  Lys Ala Gly Pro Gln  Gly Arg Gly 
    1430                 1435                 1440             


Gly Val  Ser Ala Val Pro Gly  Phe Arg Gly Asp Glu  Gly Pro Ile 
    1445                 1450                 1455             


Gly His  Gln Gly Pro Ile Gly  Gln Glu Gly Ala Pro  Gly Arg Pro 
    1460                 1465                 1470             


Gly Ser  Pro Gly Leu Pro Gly  Met Pro Gly Arg Ser  Val Ser Ile 
    1475                 1480                 1485             


Gly Tyr  Leu Leu Val Lys His  Ser Gln Thr Asp Gln  Glu Pro Met 
    1490                 1495                 1500             


Cys Pro  Val Gly Met Asn Lys  Leu Trp Ser Gly Tyr  Ser Leu Leu 
    1505                 1510                 1515             


Tyr Phe  Glu Gly Gln Glu Lys  Ala His Asn Gln Asp  Leu Gly Leu 
    1520                 1525                 1530             


Ala Gly  Ser Cys Leu Ala Arg  Phe Ser Thr Met Pro  Phe Leu Tyr 
    1535                 1540                 1545             


Cys Asn  Pro Gly Asp Val Cys  Tyr Tyr Ala Ser Arg  Asn Asp Lys 
    1550                 1555                 1560             


Ser Tyr  Trp Leu Ser Thr Thr  Ala Pro Leu Pro Met  Met Pro Val 
    1565                 1570                 1575             


Ala Glu  Asp Glu Ile Lys Pro  Tyr Ile Ser Arg Cys  Ser Val Cys 
    1580                 1585                 1590             


Glu Ala  Pro Ala Ile Ala Ile  Ala Val His Ser Gln  Asp Val Ser 
    1595                 1600                 1605             


Ile Pro  His Cys Pro Ala Gly  Trp Arg Ser Leu Trp  Ile Gly Tyr 
    1610                 1615                 1620             


Ser Phe  Leu Met His Thr Ala  Ala Gly Asp Glu Gly  Gly Gly Gln 
    1625                 1630                 1635             


Ser Leu  Val Ser Pro Gly Ser  Cys Leu Glu Asp Phe  Arg Ala Thr 
    1640                 1645                 1650             


Pro Phe  Ile Glu Cys Asn Gly  Gly Arg Gly Thr Cys  His Tyr Tyr 
    1655                 1660                 1665             


Ala Asn  Lys Tyr Ser Phe Trp  Leu Thr Thr Ile Pro  Glu Gln Ser 
    1670                 1675                 1680             


Phe Gln  Gly Ser Pro Ser Ala  Asp Thr Leu Lys Ala  Gly Leu Ile 
    1685                 1690                 1695             


Arg Thr  His Ile Ser Arg Cys  Gln Val Cys Met Lys  Asn Leu 
    1700                 1705                 1710         


<210>  2489
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  2489

Met Asp His Ser His His Met Gly Met Ser Tyr Met Asp Ser Asn Ser 
1               5                   10                  15      


Thr Met Gln Pro Ser His His His Pro Thr Thr Ser Ala Ser His Ser 
            20                  25                  30          


His Gly Gly Gly Asp Ser Ser Met Met Met Met Pro Met Thr Phe Tyr 
        35                  40                  45              


Phe Gly Phe Lys Asn Val Glu Leu Leu Phe Ser Gly Leu Val Ile Asn 
    50                  55                  60                  


Thr Ala Gly Glu Met Ala Gly Ala Phe Val Ala Val Phe Leu Leu Ala 
65                  70                  75                  80  


Met Phe Tyr Glu Gly Leu Lys Ile Ala Arg Glu Ser Leu Leu Arg Lys 
                85                  90                  95      


Ser Gln Val Ser Ile Arg Tyr Asn Ser Met Pro Val Pro Gly Pro Asn 
            100                 105                 110         


Gly Thr Ile Leu Met Glu Thr His Lys Thr Val Gly Gln Gln Met Leu 
        115                 120                 125             


Ser Phe Pro His Leu Leu Gln Thr Val Leu His Ile Ile Gln Val Val 
    130                 135                 140                 


Ile Ser Tyr Phe Leu Met Leu Ile Phe Met Thr Tyr Asn Gly Tyr Leu 
145                 150                 155                 160 


Cys Ile Ala Val Ala Ala Gly Ala Gly Thr Gly Tyr Phe Leu Phe Ser 
                165                 170                 175     


Trp Lys Lys Ala Val Val Val Asp Ile Thr Glu His Cys His 
            180                 185                 190 


<210>  2490
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  2490

Met Ala Met His Phe Ile Phe Ser Asp Thr Ala Val Leu Leu Phe Asp 
1               5                   10                  15      


Phe Trp Ser Val His Ser Pro Ala Gly Met Ala Leu Ser Val Leu Val 
            20                  25                  30          


Leu Leu Leu Leu Ala Val Leu Tyr Glu Gly Ile Lys Val Gly Lys Ala 
        35                  40                  45              


Lys Leu Leu Asn Gln Val Leu Val Asn Leu Pro Thr Ser Ile Ser Gln 
    50                  55                  60                  


Gln Thr Ile Ala Glu Thr Asp Gly Asp Ser Ala Gly Ser Asp Ser Phe 
65                  70                  75                  80  


Pro Val Gly Arg Thr His His Arg Trp Tyr Leu Cys His Phe Gly Gln 
                85                  90                  95      


Ser Leu Ile His Val Ile Gln Val Val Ile Gly Tyr Phe Ile Met Leu 
            100                 105                 110         


Ala Val Met Ser Tyr Asn Thr Trp Ile Phe Leu Gly Val Val Leu Gly 
        115                 120                 125             


Ser Ala Val Gly Tyr Tyr Leu Ala Tyr Pro Leu Leu Ser Thr Ala 
    130                 135                 140             


<210>  2491
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  2491

Met Leu Ala Thr Arg Val Phe Ser Leu Val Gly Lys Arg Ala Ile Ser 
1               5                   10                  15      


Thr Ser Val Cys Val Arg Ala His Glu Ser Val Val Lys Ser Glu Asp 
            20                  25                  30          


Phe Ser Leu Pro Ala Tyr Met Asp Arg Arg Asp His Pro Leu Pro Glu 
        35                  40                  45              


Val Ala His Val Lys His Leu Ser Ala Ser Gln Lys Ala Leu Lys Glu 
    50                  55                  60                  


Lys Glu Lys Ala Ser Trp Ser Ser Leu Ser Met Asp Glu Lys Val Glu 
65                  70                  75                  80  


Leu Tyr Arg Ile Lys Phe Lys Glu Ser Phe Ala Glu Met Asn Arg Gly 
                85                  90                  95      


Ser Asn Glu Trp Lys Thr Val Val Gly Gly Ala Met Phe Phe Ile Gly 
            100                 105                 110         


Phe Thr Ala Leu Val Ile Met Trp Gln Lys His Tyr Val Tyr Gly Pro 
        115                 120                 125             


Leu Pro Gln Ser Phe Asp Lys Glu Trp Val Ala Lys Gln Thr Lys Arg 
    130                 135                 140                 


Met Leu Asp Met Lys Val Asn Pro Ile Gln Gly Leu Ala Ser Lys Trp 
145                 150                 155                 160 


Asp Tyr Glu Lys Asn Glu Trp Lys Lys 
                165                 


<210>  2492
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  2492

Met Gln Ala Leu Arg Val Ser Gln Ala Leu Ile Arg Ser Phe Ser Ser 
1               5                   10                  15      


Thr Ala Arg Asn Arg Phe Gln Asn Arg Val Arg Glu Lys Gln Lys Leu 
            20                  25                  30          


Phe Gln Glu Asp Asn Asp Ile Pro Leu Tyr Leu Lys Gly Gly Ile Val 
        35                  40                  45              


Asp Asn Ile Leu Tyr Arg Val Thr Met Thr Leu Cys Leu Gly Gly Thr 
    50                  55                  60                  


Val Tyr Ser Leu Tyr Ser Leu Gly Trp Ala Ser Phe Pro Arg Asn 
65                  70                  75                  


<210>  2493
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  2493

Met His Thr Gln Asp Ser Glu Val Val Pro Val Pro Ala Trp Pro Phe 
1               5                   10                  15      


Ser Leu Val Val Phe Ser Cys Gly Gly Cys Trp Ser Val Thr Ala Lys 
            20                  25                  30          


Met Leu Arg Asn Leu Leu Ala Leu Arg Gln Ile Gly Gln Arg Thr Ile 
        35                  40                  45              


Ser Thr Ala Ser Arg Arg His Phe Lys Asn Lys Val Pro Glu Lys Gln 
    50                  55                  60                  


Lys Leu Phe Gln Glu Asp Asp Glu Ile Pro Leu Tyr Leu Lys Gly Gly 
65                  70                  75                  80  


Val Ala Asp Ala Leu Leu Tyr Arg Ala Thr Met Ile Leu Thr Val Gly 
                85                  90                  95      


Gly Thr Ala Tyr Ala Ile Tyr Glu Leu Ala Val Ala Ser Phe Pro Lys 
            100                 105                 110         


Lys Gln Glu 
        115 


<210>  2494
<211>  773
<212>  PRT
<213>  Homo sapiens

<400>  2494

Met Ala Glu Ala His Gln Ala Val Ala Phe Gln Phe Thr Val Thr Pro 
1               5                   10                  15      


Asp Gly Ile Asp Leu Arg Leu Ser His Glu Ala Leu Arg Gln Ile Tyr 
            20                  25                  30          


Leu Ser Gly Leu His Ser Trp Lys Lys Lys Phe Ile Arg Phe Lys Asn 
        35                  40                  45              


Gly Ile Ile Thr Gly Val Tyr Pro Ala Ser Pro Ser Ser Trp Leu Ile 
    50                  55                  60                  


Val Val Val Gly Val Met Thr Thr Met Tyr Ala Lys Ile Asp Pro Ser 
65                  70                  75                  80  


Leu Gly Ile Ile Ala Lys Ile Asn Arg Thr Leu Glu Thr Ala Asn Cys 
                85                  90                  95      


Met Ser Ser Gln Thr Lys Asn Val Val Ser Gly Val Leu Phe Gly Thr 
            100                 105                 110         


Gly Leu Trp Val Ala Leu Ile Val Thr Met Arg Tyr Ser Leu Lys Val 
        115                 120                 125             


Leu Leu Ser Tyr His Gly Trp Met Phe Thr Glu His Gly Lys Met Ser 
    130                 135                 140                 


Arg Ala Thr Lys Ile Trp Met Gly Met Val Lys Ile Phe Ser Gly Arg 
145                 150                 155                 160 


Lys Pro Met Leu Tyr Ser Phe Gln Thr Ser Leu Pro Arg Leu Pro Val 
                165                 170                 175     


Pro Ala Val Lys Asp Thr Val Asn Arg Tyr Leu Gln Ser Val Arg Pro 
            180                 185                 190         


Leu Met Lys Glu Glu Asp Phe Lys Arg Met Thr Ala Leu Ala Gln Asp 
        195                 200                 205             


Phe Ala Val Gly Leu Gly Pro Arg Leu Gln Trp Tyr Leu Lys Leu Lys 
    210                 215                 220                 


Ser Trp Trp Ala Thr Asn Tyr Val Ser Asp Trp Trp Glu Glu Tyr Ile 
225                 230                 235                 240 


Tyr Leu Arg Gly Arg Gly Pro Leu Met Val Asn Ser Asn Tyr Tyr Ala 
                245                 250                 255     


Met Asp Leu Leu Tyr Ile Leu Pro Thr His Ile Gln Ala Ala Arg Ala 
            260                 265                 270         


Gly Asn Ala Ile His Ala Ile Leu Leu Tyr Arg Arg Lys Leu Asp Arg 
        275                 280                 285             


Glu Glu Ile Lys Pro Ile Arg Leu Leu Gly Ser Thr Ile Pro Leu Cys 
    290                 295                 300                 


Ser Ala Gln Trp Glu Arg Met Phe Asn Thr Ser Arg Ile Pro Gly Glu 
305                 310                 315                 320 


Glu Thr Asp Thr Ile Gln His Met Arg Asp Ser Lys His Ile Val Val 
                325                 330                 335     


Tyr His Arg Gly Arg Tyr Phe Lys Val Trp Leu Tyr His Asp Gly Arg 
            340                 345                 350         


Leu Leu Lys Pro Arg Glu Met Glu Gln Gln Met Gln Arg Ile Leu Asp 
        355                 360                 365             


Asn Thr Ser Glu Pro Gln Pro Gly Glu Ala Arg Leu Ala Ala Leu Thr 
    370                 375                 380                 


Ala Gly Asp Arg Val Pro Trp Ala Arg Cys Arg Gln Ala Tyr Phe Gly 
385                 390                 395                 400 


Arg Gly Lys Asn Lys Gln Ser Leu Asp Ala Val Glu Lys Ala Ala Phe 
                405                 410                 415     


Phe Val Thr Leu Asp Glu Thr Glu Glu Gly Tyr Arg Ser Glu Asp Pro 
            420                 425                 430         


Asp Thr Ser Met Asp Ser Tyr Ala Lys Ser Leu Leu His Gly Arg Cys 
        435                 440                 445             


Tyr Asp Arg Trp Phe Asp Lys Ser Phe Thr Phe Val Val Phe Lys Asn 
    450                 455                 460                 


Gly Lys Met Gly Leu Asn Ala Glu His Ser Trp Ala Asp Ala Pro Ile 
465                 470                 475                 480 


Val Ala His Leu Trp Glu Tyr Val Met Ser Ile Asp Ser Leu Gln Leu 
                485                 490                 495     


Gly Tyr Ala Glu Asp Gly His Cys Lys Gly Asp Ile Asn Pro Asn Ile 
            500                 505                 510         


Pro Tyr Pro Thr Arg Leu Gln Trp Asp Ile Pro Gly Glu Cys Gln Glu 
        515                 520                 525             


Val Ile Glu Thr Ser Leu Asn Thr Ala Asn Leu Leu Ala Asn Asp Val 
    530                 535                 540                 


Asp Phe His Ser Phe Pro Phe Val Ala Phe Gly Lys Gly Ile Ile Lys 
545                 550                 555                 560 


Lys Cys Arg Thr Ser Pro Asp Ala Phe Val Gln Leu Ala Leu Gln Leu 
                565                 570                 575     


Ala His Tyr Lys Asp Met Gly Lys Phe Cys Leu Thr Tyr Glu Ala Ser 
            580                 585                 590         


Met Thr Arg Leu Phe Arg Glu Gly Arg Thr Glu Thr Val Arg Ser Cys 
        595                 600                 605             


Thr Thr Glu Ser Cys Asp Phe Val Arg Ala Met Val Asp Pro Ala Gln 
    610                 615                 620                 


Thr Val Glu Gln Arg Leu Lys Leu Phe Lys Leu Ala Ser Glu Lys His 
625                 630                 635                 640 


Gln His Met Tyr Arg Leu Ala Met Thr Gly Ser Gly Ile Asp Arg His 
                645                 650                 655     


Leu Phe Cys Leu Tyr Val Val Ser Lys Tyr Leu Ala Val Glu Ser Pro 
            660                 665                 670         


Phe Leu Lys Glu Val Leu Ser Glu Pro Trp Arg Leu Ser Thr Ser Gln 
        675                 680                 685             


Thr Pro Gln Gln Gln Val Glu Leu Phe Asp Leu Glu Asn Asn Pro Glu 
    690                 695                 700                 


Tyr Val Ser Ser Gly Gly Gly Phe Gly Pro Val Ala Asp Asp Gly Tyr 
705                 710                 715                 720 


Gly Val Ser Tyr Ile Leu Val Gly Glu Asn Leu Ile Asn Phe His Ile 
                725                 730                 735     


Ser Ser Lys Phe Ser Cys Pro Glu Thr Asp Ser His Arg Phe Gly Arg 
            740                 745                 750         


His Leu Lys Glu Ala Met Thr Asp Ile Ile Thr Leu Phe Gly Leu Ser 
        755                 760                 765             


Ser Asn Ser Lys Lys 
    770             


<210>  2495
<211>  1033
<212>  PRT
<213>  Homo sapiens

<400>  2495

Met Gly Ala Ala Gly Leu Leu Gly Val Phe Leu Ala Leu Val Ala Pro 
1               5                   10                  15      


Gly Val Leu Gly Ile Ser Cys Gly Ser Pro Pro Pro Ile Leu Asn Gly 
            20                  25                  30          


Arg Ile Ser Tyr Tyr Ser Thr Pro Ile Ala Val Gly Thr Val Ile Arg 
        35                  40                  45              


Tyr Ser Cys Ser Gly Thr Phe Arg Leu Ile Gly Glu Lys Ser Leu Leu 
    50                  55                  60                  


Cys Ile Thr Lys Asp Lys Val Asp Gly Thr Trp Asp Lys Pro Ala Pro 
65                  70                  75                  80  


Lys Cys Glu Tyr Phe Asn Lys Tyr Ser Ser Cys Pro Glu Pro Ile Val 
                85                  90                  95      


Pro Gly Gly Tyr Lys Ile Arg Gly Ser Thr Pro Tyr Arg His Gly Asp 
            100                 105                 110         


Ser Val Thr Phe Ala Cys Lys Thr Asn Phe Ser Met Asn Gly Asn Lys 
        115                 120                 125             


Ser Val Trp Cys Gln Ala Asn Asn Met Trp Gly Pro Thr Arg Leu Pro 
    130                 135                 140                 


Thr Cys Val Ser Val Phe Pro Leu Glu Cys Pro Ala Leu Pro Met Ile 
145                 150                 155                 160 


His Asn Gly His His Thr Ser Glu Asn Val Gly Ser Ile Ala Pro Gly 
                165                 170                 175     


Leu Ser Val Thr Tyr Ser Cys Glu Ser Gly Tyr Leu Leu Val Gly Glu 
            180                 185                 190         


Lys Ile Ile Asn Cys Leu Ser Ser Gly Lys Trp Ser Ala Val Pro Pro 
        195                 200                 205             


Thr Cys Glu Glu Ala Arg Cys Lys Ser Leu Gly Arg Phe Pro Asn Gly 
    210                 215                 220                 


Lys Val Lys Glu Pro Pro Ile Leu Arg Val Gly Val Thr Ala Asn Phe 
225                 230                 235                 240 


Phe Cys Asp Glu Gly Tyr Arg Leu Gln Gly Pro Pro Ser Ser Arg Cys 
                245                 250                 255     


Val Ile Ala Gly Gln Gly Val Ala Trp Thr Lys Met Pro Val Cys Glu 
            260                 265                 270         


Glu Ile Phe Cys Pro Ser Pro Pro Pro Ile Leu Asn Gly Arg His Ile 
        275                 280                 285             


Gly Asn Ser Leu Ala Asn Val Ser Tyr Gly Ser Ile Val Thr Tyr Thr 
    290                 295                 300                 


Cys Asp Pro Asp Pro Glu Glu Gly Val Asn Phe Ile Leu Ile Gly Glu 
305                 310                 315                 320 


Ser Thr Leu Arg Cys Thr Val Asp Ser Gln Lys Thr Gly Thr Trp Ser 
                325                 330                 335     


Gly Pro Ala Pro Arg Cys Glu Leu Ser Thr Ser Ala Val Gln Cys Pro 
            340                 345                 350         


His Pro Gln Ile Leu Arg Gly Arg Met Val Ser Gly Gln Lys Asp Arg 
        355                 360                 365             


Tyr Thr Tyr Asn Asp Thr Val Ile Phe Ala Cys Met Phe Gly Phe Thr 
    370                 375                 380                 


Leu Lys Gly Ser Lys Gln Ile Arg Cys Asn Ala Gln Gly Thr Trp Glu 
385                 390                 395                 400 


Pro Ser Ala Pro Val Cys Glu Lys Glu Cys Gln Ala Pro Pro Asn Ile 
                405                 410                 415     


Leu Asn Gly Gln Lys Glu Asp Arg His Met Val Arg Phe Asp Pro Gly 
            420                 425                 430         


Thr Ser Ile Lys Tyr Ser Cys Asn Pro Gly Tyr Val Leu Val Gly Glu 
        435                 440                 445             


Glu Ser Ile Gln Cys Thr Ser Glu Gly Val Trp Thr Pro Pro Val Pro 
    450                 455                 460                 


Gln Cys Lys Val Ala Ala Cys Glu Ala Thr Gly Arg Gln Leu Leu Thr 
465                 470                 475                 480 


Lys Pro Gln His Gln Phe Val Arg Pro Asp Val Asn Ser Ser Cys Gly 
                485                 490                 495     


Glu Gly Tyr Lys Leu Ser Gly Ser Val Tyr Gln Glu Cys Gln Gly Thr 
            500                 505                 510         


Ile Pro Trp Phe Met Glu Ile Arg Leu Cys Lys Glu Ile Thr Cys Pro 
        515                 520                 525             


Pro Pro Pro Val Ile Tyr Asn Gly Ala His Thr Gly Ser Ser Leu Glu 
    530                 535                 540                 


Asp Phe Pro Tyr Gly Thr Thr Val Thr Tyr Thr Cys Asn Pro Gly Pro 
545                 550                 555                 560 


Glu Arg Gly Val Glu Phe Ser Leu Ile Gly Glu Ser Thr Ile Arg Cys 
                565                 570                 575     


Thr Ser Asn Asp Gln Glu Arg Gly Thr Trp Ser Gly Pro Ala Pro Leu 
            580                 585                 590         


Cys Lys Leu Ser Leu Leu Ala Val Gln Cys Ser His Val His Ile Ala 
        595                 600                 605             


Asn Gly Tyr Lys Ile Ser Gly Lys Glu Ala Pro Tyr Phe Tyr Asn Asp 
    610                 615                 620                 


Thr Val Thr Phe Lys Cys Tyr Ser Gly Phe Thr Leu Lys Gly Ser Ser 
625                 630                 635                 640 


Gln Ile Arg Cys Lys Ala Asp Asn Thr Trp Asp Pro Glu Ile Pro Val 
                645                 650                 655     


Cys Glu Lys Glu Thr Cys Gln His Val Arg Gln Ser Leu Gln Glu Leu 
            660                 665                 670         


Pro Ala Gly Ser Arg Val Glu Leu Val Asn Thr Ser Cys Gln Asp Gly 
        675                 680                 685             


Tyr Gln Leu Thr Gly His Ala Tyr Gln Met Cys Gln Asp Ala Glu Asn 
    690                 695                 700                 


Gly Ile Trp Phe Lys Lys Ile Pro Leu Cys Lys Val Ile His Cys His 
705                 710                 715                 720 


Pro Pro Pro Val Ile Val Asn Gly Lys His Thr Gly Met Met Ala Glu 
                725                 730                 735     


Asn Phe Leu Tyr Gly Asn Glu Val Ser Tyr Glu Cys Asp Gln Gly Phe 
            740                 745                 750         


Tyr Leu Leu Gly Glu Lys Lys Leu Gln Cys Arg Ser Asp Ser Lys Gly 
        755                 760                 765             


His Gly Ser Trp Ser Gly Pro Ser Pro Gln Cys Leu Arg Ser Pro Pro 
    770                 775                 780                 


Val Thr Arg Cys Pro Asn Pro Glu Val Lys His Gly Tyr Lys Leu Asn 
785                 790                 795                 800 


Lys Thr His Ser Ala Tyr Ser His Asn Asp Ile Val Tyr Val Asp Cys 
                805                 810                 815     


Asn Pro Gly Phe Ile Met Asn Gly Ser Arg Val Ile Arg Cys His Thr 
            820                 825                 830         


Asp Asn Thr Trp Val Pro Gly Val Pro Thr Cys Ile Lys Lys Ala Phe 
        835                 840                 845             


Ile Gly Cys Pro Pro Pro Pro Lys Thr Pro Asn Gly Asn His Thr Gly 
    850                 855                 860                 


Gly Asn Ile Ala Arg Phe Ser Pro Gly Met Ser Ile Leu Tyr Ser Cys 
865                 870                 875                 880 


Asp Gln Gly Tyr Leu Leu Val Gly Glu Ala Leu Leu Leu Cys Thr His 
                885                 890                 895     


Glu Gly Thr Trp Ser Gln Pro Ala Pro His Cys Lys Glu Val Asn Cys 
            900                 905                 910         


Ser Ser Pro Ala Asp Met Asp Gly Ile Gln Lys Gly Leu Glu Pro Arg 
        915                 920                 925             


Lys Met Tyr Gln Tyr Gly Ala Val Val Thr Leu Glu Cys Glu Asp Gly 
    930                 935                 940                 


Tyr Met Leu Glu Gly Ser Pro Gln Ser Gln Cys Gln Ser Asp His Gln 
945                 950                 955                 960 


Trp Asn Pro Pro Leu Ala Val Cys Arg Ser Arg Ser Leu Ala Pro Val 
                965                 970                 975     


Leu Cys Gly Ile Ala Ala Gly Leu Ile Leu Leu Thr Phe Leu Ile Val 
            980                 985                 990         


Ile Thr Leu Tyr Val Ile Ser Lys  His Arg Ala Arg Asn  Tyr Tyr Thr 
        995                 1000                 1005             


Asp Thr  Ser Gln Lys Glu Ala  Phe His Leu Glu Ala  Arg Glu Val 
    1010                 1015                 1020             


Tyr Ser  Val Asp Pro Tyr Asn  Pro Ala Ser 
    1025                 1030             


<210>  2496
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  2496

Met Asp Ala Ala Leu Leu His Ser Leu Leu Glu Ala Asn Cys Ser Leu 
1               5                   10                  15      


Ala Leu Ala Glu Glu Leu Leu Leu Asp Gly Trp Gly Pro Pro Leu Asp 
            20                  25                  30          


Pro Glu Gly Pro Tyr Ser Tyr Cys Asn Thr Thr Leu Asp Gln Ile Gly 
        35                  40                  45              


Thr Cys Trp Pro Arg Ser Ala Ala Gly Ala Leu Val Glu Arg Pro Cys 
    50                  55                  60                  


Pro Glu Tyr Phe Asn Gly Val Lys Tyr Asn Thr Thr Arg Asn Ala Tyr 
65                  70                  75                  80  


Arg Glu Cys Leu Glu Asn Gly Thr Trp Ala Ser Lys Ile Asn Tyr Ser 
                85                  90                  95      


Gln Cys Glu Pro Ile Leu Asp Asp Lys Gln Arg Lys Tyr Asp Leu His 
            100                 105                 110         


Tyr Arg Ile Ala Leu Val Val Asn Tyr Leu Gly His Cys Val Ser Val 
        115                 120                 125             


Ala Ala Leu Val Ala Ala Phe Leu Leu Phe Leu Ala Leu Arg Ser Ile 
    130                 135                 140                 


Arg Cys Leu Arg Asn Val Ile His Trp Asn Leu Ile Thr Thr Phe Ile 
145                 150                 155                 160 


Leu Arg Asn Val Met Trp Phe Leu Leu Gln Leu Val Asp His Glu Val 
                165                 170                 175     


His Glu Ser Asn Glu Val Trp Cys Arg Cys Ile Thr Thr Ile Phe Asn 
            180                 185                 190         


Tyr Phe Val Val Thr Asn Phe Phe Trp Met Phe Val Glu Gly Cys Tyr 
        195                 200                 205             


Leu His Thr Ala Ile Val Met Thr Tyr Ser Thr Glu Arg Leu Arg Lys 
    210                 215                 220                 


Cys Leu Phe Leu Phe Ile Gly Trp Cys Ile Pro Phe Pro Ile Ile Val 
225                 230                 235                 240 


Ala Trp Ala Ile Gly Lys Leu Tyr Tyr Glu Asn Glu Gln Cys Trp Phe 
                245                 250                 255     


Gly Lys Glu Pro Gly Asp Leu Val Asp Tyr Ile Tyr Gln Gly Pro Ile 
            260                 265                 270         


Ile Leu Val Leu Leu Ile Asn Phe Val Phe Leu Phe Asn Ile Val Arg 
        275                 280                 285             


Ile Leu Met Thr Lys Leu Arg Ala Ser Thr Thr Ser Glu Thr Ile Gln 
    290                 295                 300                 


Tyr Arg Lys Ala Val Lys Ala Thr Leu Val Leu Leu Pro Leu Leu Gly 
305                 310                 315                 320 


Ile Thr Tyr Met Leu Phe Phe Val Asn Pro Gly Glu Asp Asp Leu Ser 
                325                 330                 335     


Gln Ile Met Phe Ile Tyr Phe Asn Ser Phe Leu Gln Ser Phe Gln Gly 
            340                 345                 350         


Phe Phe Val Ser Val Phe Tyr Cys Phe Phe Asn Gly Glu Val Arg Ser 
        355                 360                 365             


Ala Val Arg Lys Arg Trp His Arg Trp Gln Asp His His Ser Leu Arg 
    370                 375                 380                 


Val Pro Met Ala Arg Ala Met Ser Ile Pro Thr Ser Pro Thr Arg Ile 
385                 390                 395                 400 


Ser Phe His Ser Ile Lys Gln Thr Ala Ala Val 
                405                 410     


<210>  2497
<211>  2322
<212>  PRT
<213>  Homo sapiens

<400>  2497

Met Gln Ser Gly Pro Arg Pro Pro Leu Pro Ala Pro Gly Leu Ala Leu 
1               5                   10                  15      


Ala Leu Thr Leu Thr Met Leu Ala Arg Leu Ala Ser Ala Ala Ser Phe 
            20                  25                  30          


Phe Gly Glu Asn His Leu Glu Val Pro Val Ala Thr Ala Leu Thr Asp 
        35                  40                  45              


Ile Asp Leu Gln Leu Gln Phe Ser Thr Ser Gln Pro Glu Ala Leu Leu 
    50                  55                  60                  


Leu Leu Ala Ala Gly Pro Ala Asp His Leu Leu Leu Gln Leu Tyr Ser 
65                  70                  75                  80  


Gly Arg Leu Gln Val Arg Leu Val Leu Gly Gln Glu Glu Leu Arg Leu 
                85                  90                  95      


Gln Thr Pro Ala Glu Thr Leu Leu Ser Asp Ser Ile Pro His Thr Val 
            100                 105                 110         


Val Leu Thr Val Val Glu Gly Trp Ala Thr Leu Ser Val Asp Gly Phe 
        115                 120                 125             


Leu Asn Ala Ser Ser Ala Val Pro Gly Ala Pro Leu Glu Val Pro Tyr 
    130                 135                 140                 


Gly Leu Phe Val Gly Gly Thr Gly Thr Leu Gly Leu Pro Tyr Leu Arg 
145                 150                 155                 160 


Gly Thr Ser Arg Pro Leu Arg Gly Cys Leu His Ala Ala Thr Leu Asn 
                165                 170                 175     


Gly Arg Ser Leu Leu Arg Pro Leu Thr Pro Asp Val His Glu Gly Cys 
            180                 185                 190         


Ala Glu Glu Phe Ser Ala Ser Asp Asp Val Ala Leu Gly Phe Ser Gly 
        195                 200                 205             


Pro His Ser Leu Ala Ala Phe Pro Ala Trp Gly Thr Gln Asp Glu Gly 
    210                 215                 220                 


Thr Leu Glu Phe Thr Leu Thr Thr Gln Ser Arg Gln Ala Pro Leu Ala 
225                 230                 235                 240 


Phe Gln Ala Gly Gly Arg Arg Gly Asp Phe Ile Tyr Val Asp Ile Phe 
                245                 250                 255     


Glu Gly His Leu Arg Ala Val Val Glu Lys Gly Gln Gly Thr Val Leu 
            260                 265                 270         


Leu His Asn Ser Val Pro Val Ala Asp Gly Gln Pro His Glu Val Ser 
        275                 280                 285             


Val His Ile Asn Ala His Arg Leu Glu Ile Ser Val Asp Gln Tyr Pro 
    290                 295                 300                 


Thr His Thr Ser Asn Arg Gly Val Leu Ser Tyr Leu Glu Pro Arg Gly 
305                 310                 315                 320 


Ser Leu Leu Leu Gly Gly Leu Asp Ala Glu Ala Ser Arg His Leu Gln 
                325                 330                 335     


Glu His Arg Leu Gly Leu Thr Pro Glu Ala Thr Asn Ala Ser Leu Leu 
            340                 345                 350         


Gly Cys Met Glu Asp Leu Ser Val Asn Gly Gln Arg Arg Gly Leu Arg 
        355                 360                 365             


Glu Ala Leu Leu Thr Arg Asn Met Ala Ala Gly Cys Arg Leu Glu Glu 
    370                 375                 380                 


Glu Glu Tyr Glu Asp Asp Ala Tyr Gly His Tyr Glu Ala Phe Ser Thr 
385                 390                 395                 400 


Leu Ala Pro Glu Ala Trp Pro Ala Met Glu Leu Pro Glu Pro Cys Val 
                405                 410                 415     


Pro Glu Pro Gly Leu Pro Pro Val Phe Ala Asn Phe Thr Gln Leu Leu 
            420                 425                 430         


Thr Ile Ser Pro Leu Val Val Ala Glu Gly Gly Thr Ala Trp Leu Glu 
        435                 440                 445             


Trp Arg His Val Gln Pro Thr Leu Asp Leu Met Glu Ala Glu Leu Arg 
    450                 455                 460                 


Lys Ser Gln Val Leu Phe Ser Val Thr Arg Gly Ala Arg His Gly Glu 
465                 470                 475                 480 


Leu Glu Leu Asp Ile Pro Gly Ala Gln Ala Arg Lys Met Phe Thr Leu 
                485                 490                 495     


Leu Asp Val Val Asn Arg Lys Ala Arg Phe Ile His Asp Gly Ser Glu 
            500                 505                 510         


Asp Thr Ser Asp Gln Leu Val Leu Glu Val Ser Val Thr Ala Arg Val 
        515                 520                 525             


Pro Met Pro Ser Cys Leu Arg Arg Gly Gln Thr Tyr Leu Leu Pro Ile 
    530                 535                 540                 


Gln Val Asn Pro Val Asn Asp Pro Pro His Ile Ile Phe Pro His Gly 
545                 550                 555                 560 


Ser Leu Met Val Ile Leu Glu His Thr Gln Lys Pro Leu Gly Pro Glu 
                565                 570                 575     


Val Phe Gln Ala Tyr Asp Pro Asp Ser Ala Cys Glu Gly Leu Thr Phe 
            580                 585                 590         


Gln Val Leu Gly Thr Ser Ser Gly Leu Pro Val Glu Arg Arg Asp Gln 
        595                 600                 605             


Pro Gly Glu Pro Ala Thr Glu Phe Ser Cys Arg Glu Leu Glu Ala Gly 
    610                 615                 620                 


Ser Leu Val Tyr Val His Arg Gly Gly Pro Ala Gln Asp Leu Thr Phe 
625                 630                 635                 640 


Arg Val Ser Asp Gly Leu Gln Ala Ser Pro Pro Ala Thr Leu Lys Val 
                645                 650                 655     


Val Ala Ile Arg Pro Ala Ile Gln Ile His Arg Ser Thr Gly Leu Arg 
            660                 665                 670         


Leu Ala Gln Gly Ser Ala Met Pro Ile Leu Pro Ala Asn Leu Ser Val 
        675                 680                 685             


Glu Thr Asn Ala Val Gly Gln Asp Val Ser Val Leu Phe Arg Val Thr 
    690                 695                 700                 


Gly Ala Leu Gln Phe Gly Glu Leu Gln Lys Gln Gly Ala Gly Gly Val 
705                 710                 715                 720 


Glu Gly Ala Glu Trp Trp Ala Thr Gln Ala Phe His Gln Arg Asp Val 
                725                 730                 735     


Glu Gln Gly Arg Val Arg Tyr Leu Ser Thr Asp Pro Gln His His Ala 
            740                 745                 750         


Tyr Asp Thr Val Glu Asn Leu Ala Leu Glu Val Gln Val Gly Gln Glu 
        755                 760                 765             


Ile Leu Ser Asn Leu Ser Phe Pro Val Thr Ile Gln Arg Ala Thr Val 
    770                 775                 780                 


Trp Met Leu Arg Leu Glu Pro Leu His Thr Gln Asn Thr Gln Gln Glu 
785                 790                 795                 800 


Thr Leu Thr Thr Ala His Leu Glu Ala Thr Leu Glu Glu Ala Gly Pro 
                805                 810                 815     


Ser Pro Pro Thr Phe His Tyr Glu Val Val Gln Ala Pro Arg Lys Gly 
            820                 825                 830         


Asn Leu Gln Leu Gln Gly Thr Arg Leu Ser Asp Gly Gln Gly Phe Thr 
        835                 840                 845             


Gln Asp Asp Ile Gln Ala Gly Arg Val Thr Tyr Gly Ala Thr Ala Arg 
    850                 855                 860                 


Ala Ser Glu Ala Val Glu Asp Thr Phe Arg Phe Arg Val Thr Ala Pro 
865                 870                 875                 880 


Pro Tyr Phe Ser Pro Leu Tyr Thr Phe Pro Ile His Ile Gly Gly Asp 
                885                 890                 895     


Pro Asp Ala Pro Val Leu Thr Asn Val Leu Leu Val Val Pro Glu Gly 
            900                 905                 910         


Gly Glu Gly Val Leu Ser Ala Asp His Leu Phe Val Lys Ser Leu Asn 
        915                 920                 925             


Ser Ala Ser Tyr Leu Tyr Glu Val Met Glu Arg Pro Arg His Gly Arg 
    930                 935                 940                 


Leu Ala Trp Arg Gly Thr Gln Asp Lys Thr Thr Met Val Thr Ser Phe 
945                 950                 955                 960 


Thr Asn Glu Asp Leu Leu Arg Gly Arg Leu Val Tyr Gln His Asp Asp 
                965                 970                 975     


Ser Glu Thr Thr Glu Asp Asp Ile Pro Phe Val Ala Thr Arg Gln Gly 
            980                 985                 990         


Glu Ser Ser Gly Asp Met Ala Trp  Glu Glu Val Arg Gly  Val Phe Arg 
        995                 1000                 1005             


Val Ala  Ile Gln Pro Val Asn  Asp His Ala Pro Val  Gln Thr Ile 
    1010                 1015                 1020             


Ser Arg  Ile Phe His Val Ala  Arg Gly Gly Arg Arg  Leu Leu Thr 
    1025                 1030                 1035             


Thr Asp  Asp Val Ala Phe Ser  Asp Ala Asp Ser Gly  Phe Ala Asp 
    1040                 1045                 1050             


Ala Gln  Leu Val Leu Thr Arg  Lys Asp Leu Leu Phe  Gly Ser Ile 
    1055                 1060                 1065             


Val Ala  Val Asp Glu Pro Thr  Arg Pro Ile Tyr Arg  Phe Thr Gln 
    1070                 1075                 1080             


Glu Asp  Leu Arg Lys Arg Arg  Val Leu Phe Val His  Ser Gly Ala 
    1085                 1090                 1095             


Asp Arg  Gly Trp Ile Gln Leu  Gln Val Ser Asp Gly  Gln His Gln 
    1100                 1105                 1110             


Ala Thr  Ala Leu Leu Glu Val  Gln Ala Ser Glu Pro  Tyr Leu Arg 
    1115                 1120                 1125             


Val Ala  Asn Gly Ser Ser Leu  Val Val Pro Gln Gly  Gly Gln Gly 
    1130                 1135                 1140             


Thr Ile  Asp Thr Ala Val Leu  His Leu Asp Thr Asn  Leu Asp Ile 
    1145                 1150                 1155             


Arg Ser  Gly Asp Glu Val His  Tyr His Val Thr Ala  Gly Pro Arg 
    1160                 1165                 1170             


Trp Gly  Gln Leu Val Arg Ala  Gly Gln Pro Ala Thr  Ala Phe Ser 
    1175                 1180                 1185             


Gln Gln  Asp Leu Leu Asp Gly  Ala Val Leu Tyr Ser  His Asn Gly 
    1190                 1195                 1200             


Ser Leu  Ser Pro Arg Asp Thr  Met Ala Phe Ser Val  Glu Ala Gly 
    1205                 1210                 1215             


Pro Val  His Thr Asp Ala Thr  Leu Gln Val Thr Ile  Ala Leu Glu 
    1220                 1225                 1230             


Gly Pro  Leu Ala Pro Leu Lys  Leu Val Arg His Lys  Lys Ile Tyr 
    1235                 1240                 1245             


Val Phe  Gln Gly Glu Ala Ala  Glu Ile Arg Arg Asp  Gln Leu Glu 
    1250                 1255                 1260             


Ala Ala  Gln Glu Ala Val Pro  Pro Ala Asp Ile Val  Phe Ser Val 
    1265                 1270                 1275             


Lys Ser  Pro Pro Ser Ala Gly  Tyr Leu Val Met Val  Ser Arg Gly 
    1280                 1285                 1290             


Ala Leu  Ala Asp Glu Pro Pro  Ser Leu Asp Pro Val  Gln Ser Phe 
    1295                 1300                 1305             


Ser Gln  Glu Ala Val Asp Thr  Gly Arg Val Leu Tyr  Leu His Ser 
    1310                 1315                 1320             


Arg Pro  Glu Ala Trp Ser Asp  Ala Phe Ser Leu Asp  Val Ala Ser 
    1325                 1330                 1335             


Gly Leu  Gly Ala Pro Leu Glu  Gly Val Leu Val Glu  Leu Glu Val 
    1340                 1345                 1350             


Leu Pro  Ala Ala Ile Pro Leu  Glu Ala Gln Asn Phe  Ser Val Pro 
    1355                 1360                 1365             


Glu Gly  Gly Ser Leu Thr Leu  Ala Pro Pro Leu Leu  Arg Val Ser 
    1370                 1375                 1380             


Gly Pro  Tyr Phe Pro Thr Leu  Leu Gly Leu Ser Leu  Gln Val Leu 
    1385                 1390                 1395             


Glu Pro  Pro Gln His Gly Ala  Leu Gln Lys Glu Asp  Gly Pro Gln 
    1400                 1405                 1410             


Ala Arg  Thr Leu Ser Ala Phe  Ser Trp Arg Met Val  Glu Glu Gln 
    1415                 1420                 1425             


Leu Ile  Arg Tyr Val His Asp  Gly Ser Glu Thr Leu  Thr Asp Ser 
    1430                 1435                 1440             


Phe Val  Leu Met Ala Asn Ala  Ser Glu Met Asp Arg  Gln Ser His 
    1445                 1450                 1455             


Pro Val  Ala Phe Thr Val Thr  Val Leu Pro Val Asn  Asp Gln Pro 
    1460                 1465                 1470             


Pro Ile  Leu Thr Thr Asn Thr  Gly Leu Gln Met Trp  Glu Gly Ala 
    1475                 1480                 1485             


Thr Ala  Pro Ile Pro Ala Glu  Ala Leu Arg Ser Thr  Asp Gly Asp 
    1490                 1495                 1500             


Ser Gly  Ser Glu Asp Leu Val  Tyr Thr Ile Glu Gln  Pro Ser Asn 
    1505                 1510                 1515             


Gly Arg  Val Val Leu Arg Gly  Ala Pro Gly Thr Glu  Val Arg Ser 
    1520                 1525                 1530             


Phe Thr  Gln Ala Gln Leu Asp  Gly Gly Leu Val Leu  Phe Ser His 
    1535                 1540                 1545             


Arg Gly  Thr Leu Asp Gly Gly  Phe Arg Phe Arg Leu  Ser Asp Gly 
    1550                 1555                 1560             


Glu His  Thr Ser Pro Gly His  Phe Phe Arg Val Thr  Ala Gln Lys 
    1565                 1570                 1575             


Gln Val  Leu Leu Ser Leu Lys  Gly Ser Gln Thr Leu  Thr Val Cys 
    1580                 1585                 1590             


Pro Gly  Ser Val Gln Pro Leu  Ser Ser Gln Thr Leu  Arg Ala Ser 
    1595                 1600                 1605             


Ser Ser  Ala Gly Thr Asp Pro  Gln Leu Leu Leu Tyr  Arg Val Val 
    1610                 1615                 1620             


Arg Gly  Pro Gln Leu Gly Arg  Leu Phe His Ala Gln  Gln Asp Ser 
    1625                 1630                 1635             


Thr Gly  Glu Ala Leu Val Asn  Phe Thr Gln Ala Glu  Val Tyr Ala 
    1640                 1645                 1650             


Gly Asn  Ile Leu Tyr Glu His  Glu Met Pro Pro Glu  Pro Phe Trp 
    1655                 1660                 1665             


Glu Ala  His Asp Thr Leu Glu  Leu Gln Leu Ser Ser  Pro Pro Ala 
    1670                 1675                 1680             


Arg Asp  Val Ala Ala Thr Leu  Ala Val Ala Val Ser  Phe Glu Ala 
    1685                 1690                 1695             


Ala Cys  Pro Gln Arg Pro Ser  His Leu Trp Lys Asn  Lys Gly Leu 
    1700                 1705                 1710             


Trp Val  Pro Glu Gly Gln Arg  Ala Arg Ile Thr Val  Ala Ala Leu 
    1715                 1720                 1725             


Asp Ala  Ser Asn Leu Leu Ala  Ser Val Pro Ser Pro  Gln Arg Ser 
    1730                 1735                 1740             


Glu His  Asp Val Leu Phe Gln  Val Thr Gln Phe Pro  Ser Arg Gly 
    1745                 1750                 1755             


Gln Leu  Leu Val Ser Glu Glu  Pro Leu His Ala Gly  Gln Pro His 
    1760                 1765                 1770             


Phe Leu  Gln Ser Gln Leu Ala  Ala Gly Gln Leu Val  Tyr Ala His 
    1775                 1780                 1785             


Gly Gly  Gly Gly Thr Gln Gln  Asp Gly Phe His Phe  Arg Ala His 
    1790                 1795                 1800             


Leu Gln  Gly Pro Ala Gly Ala  Ser Val Ala Gly Pro  Gln Thr Ser 
    1805                 1810                 1815             


Glu Ala  Phe Ala Ile Thr Val  Arg Asp Val Asn Glu  Arg Pro Pro 
    1820                 1825                 1830             


Gln Pro  Gln Ala Ser Val Pro  Leu Arg Leu Thr Arg  Gly Ser Arg 
    1835                 1840                 1845             


Ala Pro  Ile Ser Arg Ala Gln  Leu Ser Val Val Asp  Pro Asp Ser 
    1850                 1855                 1860             


Ala Pro  Gly Glu Ile Glu Tyr  Glu Val Gln Arg Ala  Pro His Asn 
    1865                 1870                 1875             


Gly Phe  Leu Ser Leu Val Gly  Gly Gly Leu Gly Pro  Val Thr Arg 
    1880                 1885                 1890             


Phe Thr  Gln Ala Asp Val Asp  Ser Gly Arg Leu Ala  Phe Val Ala 
    1895                 1900                 1905             


Asn Gly  Ser Ser Val Ala Gly  Ile Phe Gln Leu Ser  Met Ser Asp 
    1910                 1915                 1920             


Gly Ala  Ser Pro Pro Leu Pro  Met Ser Leu Ala Val  Asp Ile Leu 
    1925                 1930                 1935             


Pro Ser  Ala Ile Glu Val Gln  Leu Arg Ala Pro Leu  Glu Val Pro 
    1940                 1945                 1950             


Gln Ala  Leu Gly Arg Ser Ser  Leu Ser Gln Gln Gln  Leu Arg Val 
    1955                 1960                 1965             


Val Ser  Asp Arg Glu Glu Pro  Glu Ala Ala Tyr Arg  Leu Ile Gln 
    1970                 1975                 1980             


Gly Pro  Gln Tyr Gly His Leu  Leu Val Gly Gly Arg  Pro Thr Ser 
    1985                 1990                 1995             


Ala Phe  Ser Gln Phe Gln Ile  Asp Gln Gly Glu Val  Val Phe Ala 
    2000                 2005                 2010             


Phe Thr  Asn Phe Ser Ser Ser  His Asp His Phe Arg  Val Leu Ala 
    2015                 2020                 2025             


Leu Ala  Arg Gly Val Asn Ala  Ser Ala Val Val Asn  Val Thr Val 
    2030                 2035                 2040             


Arg Ala  Leu Leu His Val Trp  Ala Gly Gly Pro Trp  Pro Gln Gly 
    2045                 2050                 2055             


Ala Thr  Leu Arg Leu Asp Pro  Thr Val Leu Asp Ala  Gly Glu Leu 
    2060                 2065                 2070             


Ala Asn  Arg Thr Gly Ser Val  Pro Arg Phe Arg Leu  Leu Glu Gly 
    2075                 2080                 2085             


Pro Arg  His Gly Arg Val Val  Arg Val Pro Arg Ala  Arg Thr Glu 
    2090                 2095                 2100             


Pro Gly  Gly Ser Gln Leu Val  Glu Gln Phe Thr Gln  Gln Asp Leu 
    2105                 2110                 2115             


Glu Asp  Gly Arg Leu Gly Leu  Glu Val Gly Arg Pro  Glu Gly Arg 
    2120                 2125                 2130             


Ala Pro  Gly Pro Ala Gly Asp  Ser Leu Thr Leu Glu  Leu Trp Ala 
    2135                 2140                 2145             


Gln Gly  Val Pro Pro Ala Val  Ala Ser Leu Asp Phe  Ala Thr Glu 
    2150                 2155                 2160             


Pro Tyr  Asn Ala Ala Arg Pro  Tyr Ser Val Ala Leu  Leu Ser Val 
    2165                 2170                 2175             


Pro Glu  Ala Ala Arg Thr Glu  Ala Gly Lys Pro Glu  Ser Ser Thr 
    2180                 2185                 2190             


Pro Thr  Gly Glu Pro Gly Pro  Met Ala Ser Ser Pro  Glu Pro Ala 
    2195                 2200                 2205             


Val Ala  Lys Gly Gly Phe Leu  Ser Phe Leu Glu Ala  Asn Met Phe 
    2210                 2215                 2220             


Ser Val  Ile Ile Pro Met Cys  Leu Val Leu Leu Leu  Leu Ala Leu 
    2225                 2230                 2235             


Ile Leu  Pro Leu Leu Phe Tyr  Leu Arg Lys Arg Asn  Lys Thr Gly 
    2240                 2245                 2250             


Lys His  Asp Val Gln Val Leu  Thr Ala Lys Pro Arg  Asn Gly Leu 
    2255                 2260                 2265             


Ala Gly  Asp Thr Glu Thr Phe  Arg Lys Val Glu Pro  Gly Gln Ala 
    2270                 2275                 2280             


Ile Pro  Leu Thr Ala Val Pro  Gly Gln Gly Pro Pro  Pro Gly Gly 
    2285                 2290                 2295             


Gln Pro  Asp Pro Glu Leu Leu  Gln Phe Cys Arg Thr  Pro Asn Pro 
    2300                 2305                 2310             


Ala Leu  Lys Asn Gly Gln Tyr  Trp Val 
    2315                 2320         


<210>  2498
<211>  678
<212>  PRT
<213>  Homo sapiens

<400>  2498

Met Ala Ala Asn Val Gly Ser Met Phe Gln Tyr Trp Lys Arg Phe Asp 
1               5                   10                  15      


Leu Gln Gln Leu Gln Arg Glu Leu Asp Ala Thr Ala Thr Val Leu Ala 
            20                  25                  30          


Asn Arg Gln Asp Glu Ser Glu Gln Ser Arg Lys Arg Leu Ile Glu Gln 
        35                  40                  45              


Ser Arg Glu Phe Lys Lys Asn Thr Pro Glu Asp Leu Arg Lys Gln Val 
    50                  55                  60                  


Ala Pro Leu Leu Lys Ser Phe Gln Gly Glu Ile Asp Ala Leu Ser Lys 
65                  70                  75                  80  


Arg Ser Lys Glu Ala Glu Ala Ala Phe Leu Asn Val Tyr Lys Arg Leu 
                85                  90                  95      


Ile Asp Val Pro Asp Pro Val Pro Ala Leu Asp Leu Gly Gln Gln Leu 
            100                 105                 110         


Gln Leu Lys Val Gln Arg Leu His Asp Ile Glu Thr Glu Asn Gln Lys 
        115                 120                 125             


Leu Arg Glu Thr Leu Glu Glu Tyr Asn Lys Glu Phe Ala Glu Val Lys 
    130                 135                 140                 


Asn Gln Glu Val Thr Ile Lys Ala Leu Lys Glu Lys Ile Arg Glu Tyr 
145                 150                 155                 160 


Glu Gln Thr Leu Lys Asn Gln Ala Glu Thr Ile Ala Leu Glu Lys Glu 
                165                 170                 175     


Gln Lys Leu Gln Asn Asp Phe Ala Glu Lys Glu Arg Lys Leu Gln Glu 
            180                 185                 190         


Thr Gln Met Ser Thr Thr Ser Lys Leu Glu Glu Ala Glu His Lys Val 
        195                 200                 205             


Gln Ser Leu Gln Thr Ala Leu Glu Lys Thr Arg Thr Glu Leu Phe Asp 
    210                 215                 220                 


Leu Lys Thr Lys Tyr Asp Glu Glu Thr Thr Ala Lys Ala Asp Glu Ile 
225                 230                 235                 240 


Glu Met Ile Met Thr Asp Leu Glu Arg Ala Asn Gln Arg Ala Glu Val 
                245                 250                 255     


Ala Gln Arg Glu Ala Glu Thr Leu Arg Glu Gln Leu Ser Ser Ala Asn 
            260                 265                 270         


His Ser Leu Gln Leu Ala Ser Gln Ile Gln Lys Ala Pro Asp Val Glu 
        275                 280                 285             


Gln Ala Ile Glu Val Leu Thr Arg Ser Ser Leu Glu Val Glu Leu Ala 
    290                 295                 300                 


Ala Lys Glu Arg Glu Ile Ala Gln Leu Val Glu Asp Val Gln Arg Leu 
305                 310                 315                 320 


Gln Ala Ser Leu Thr Lys Leu Arg Glu Asn Ser Ala Ser Gln Ile Ser 
                325                 330                 335     


Gln Leu Glu Gln Gln Leu Ser Ala Lys Asn Ser Thr Leu Lys Gln Leu 
            340                 345                 350         


Glu Glu Lys Leu Lys Gly Gln Ala Asp Tyr Glu Glu Val Lys Lys Glu 
        355                 360                 365             


Leu Asn Ile Leu Lys Ser Met Glu Phe Ala Pro Ser Glu Gly Ala Gly 
    370                 375                 380                 


Thr Gln Asp Ala Ala Lys Pro Leu Glu Val Leu Leu Leu Glu Lys Asn 
385                 390                 395                 400 


Arg Ser Leu Gln Ser Glu Asn Ala Ala Leu Arg Ile Ser Asn Ser Asp 
                405                 410                 415     


Leu Ser Gly Arg Cys Ala Glu Leu Gln Val Arg Ile Thr Glu Ala Val 
            420                 425                 430         


Ala Thr Ala Thr Glu Gln Arg Glu Leu Ile Ala Arg Leu Glu Gln Asp 
        435                 440                 445             


Leu Ser Ile Ile Gln Ser Ile Gln Arg Pro Asp Ala Glu Gly Ala Ala 
    450                 455                 460                 


Glu His Arg Leu Glu Lys Ile Pro Glu Pro Ile Lys Glu Ala Thr Ala 
465                 470                 475                 480 


Leu Phe Tyr Gly Pro Ala Ala Pro Ala Ser Gly Ala Leu Pro Glu Gly 
                485                 490                 495     


Gln Val Asp Ser Leu Leu Ser Ile Ile Ser Ser Gln Arg Glu Arg Phe 
            500                 505                 510         


Arg Ala Arg Asn Gln Glu Leu Glu Ala Glu Asn Arg Leu Ala Gln His 
        515                 520                 525             


Thr Leu Gln Ala Leu Gln Ser Glu Leu Asp Ser Leu Arg Ala Asp Asn 
    530                 535                 540                 


Ile Lys Leu Phe Glu Lys Ile Lys Phe Leu Gln Ser Tyr Pro Gly Arg 
545                 550                 555                 560 


Gly Ser Gly Ser Asp Asp Thr Glu Leu Arg Tyr Ser Ser Gln Tyr Glu 
                565                 570                 575     


Glu Arg Leu Asp Pro Phe Ser Ser Phe Ser Lys Arg Glu Arg Gln Arg 
            580                 585                 590         


Lys Tyr Leu Ser Leu Ser Pro Trp Asp Lys Ala Thr Leu Ser Met Gly 
        595                 600                 605             


Arg Leu Val Leu Ser Asn Lys Met Ala Arg Thr Ile Gly Phe Phe Tyr 
    610                 615                 620                 


Thr Leu Phe Leu His Cys Leu Val Phe Leu Val Leu Tyr Lys Leu Ala 
625                 630                 635                 640 


Trp Ser Glu Ser Met Glu Arg Asp Cys Ala Thr Phe Cys Ala Lys Lys 
                645                 650                 655     


Phe Ala Asp His Leu His Lys Phe His Glu Asn Asp Asn Gly Ala Ala 
            660                 665                 670         


Ala Gly Asp Leu Trp Gln 
        675             


<210>  2499
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  2499

Met Ala Glu Gln Ser Asp Glu Ala Val Lys Tyr Tyr Thr Leu Glu Glu 
1               5                   10                  15      


Ile Gln Lys His Asn His Ser Lys Ser Thr Trp Leu Ile Leu His His 
            20                  25                  30          


Lys Val Tyr Asp Leu Thr Lys Phe Leu Glu Glu His Pro Gly Gly Glu 
        35                  40                  45              


Glu Val Leu Arg Glu Gln Ala Gly Gly Asp Ala Thr Glu Asn Phe Glu 
    50                  55                  60                  


Asp Val Gly His Ser Thr Asp Ala Arg Glu Met Ser Lys Thr Phe Ile 
65                  70                  75                  80  


Ile Gly Glu Leu His Pro Asp Asp Arg Pro Lys Leu Asn Lys Pro Pro 
                85                  90                  95      


Glu Pro 
        


<210>  2500
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  2500

Met Glu Gly Gly Ala Ala Ala Ala Thr Pro Thr Ala Leu Pro Tyr Tyr 
1               5                   10                  15      


Val Ala Phe Ser Gln Leu Leu Gly Leu Thr Leu Val Ala Met Thr Gly 
            20                  25                  30          


Ala Trp Leu Gly Leu Tyr Arg Gly Gly Ile Ala Trp Glu Ser Asp Leu 
        35                  40                  45              


Gln Phe Asn Ala His Pro Leu Cys Met Val Ile Gly Leu Ile Phe Leu 
    50                  55                  60                  


Gln Gly Asn Ala Leu Leu Val Tyr Arg Val Phe Arg Asn Glu Ala Lys 
65                  70                  75                  80  


Arg Thr Thr Lys Val Leu His Gly Leu Leu His Ile Phe Ala Leu Val 
                85                  90                  95      


Ile Ala Leu Val Gly Leu Val Ala Val Phe Asp Tyr His Arg Lys Lys 
            100                 105                 110         


Gly Tyr Ala Asp Leu Tyr Ser Leu His Ser Trp Cys Gly Ile Leu Val 
        115                 120                 125             


Phe Val Leu Tyr Phe Val Gln Trp Leu Val Gly Phe Ser Phe Phe Leu 
    130                 135                 140                 


Phe Pro Gly Ala Ser Phe Ser Leu Arg Ser Arg Tyr Arg Pro Gln His 
145                 150                 155                 160 


Ile Phe Phe Gly Ala Thr Ile Phe Leu Leu Ser Val Gly Thr Ala Leu 
                165                 170                 175     


Leu Gly Leu Lys Glu Ala Leu Leu Phe Asn Leu Gly Gly Lys Tyr Ser 
            180                 185                 190         


Ala Phe Glu Pro Glu Gly Val Leu Ala Asn Val Leu Gly Leu Leu Leu 
        195                 200                 205             


Ala Cys Phe Gly Gly Ala Val Leu Tyr Ile Leu Thr Arg Ala Asp Trp 
    210                 215                 220                 


Lys Arg Pro Ser Gln Ala Glu Glu Gln Ala Leu Ser Met Asp Phe Lys 
225                 230                 235                 240 


Thr Leu Thr Glu Gly Asp Ser Pro Gly Ser Gln 
                245                 250     


<210>  2501
<211>  519
<212>  PRT
<213>  Homo sapiens

<400>  2501

Met Ser Pro Leu Trp Trp Gly Phe Leu Leu Ser Cys Leu Gly Cys Lys 
1               5                   10                  15      


Ile Leu Pro Gly Ala Gln Gly Gln Phe Pro Arg Val Cys Met Thr Val 
            20                  25                  30          


Asp Ser Leu Val Asn Lys Glu Cys Cys Pro Arg Leu Gly Ala Glu Ser 
        35                  40                  45              


Ala Asn Val Cys Gly Ser Gln Gln Gly Arg Gly Gln Cys Thr Glu Val 
    50                  55                  60                  


Arg Ala Asp Thr Arg Pro Trp Ser Gly Pro Tyr Ile Leu Arg Asn Gln 
65                  70                  75                  80  


Asp Asp Arg Glu Leu Trp Pro Arg Lys Phe Phe His Arg Thr Cys Lys 
                85                  90                  95      


Cys Thr Gly Asn Phe Ala Gly Tyr Asn Cys Gly Asp Cys Lys Phe Gly 
            100                 105                 110         


Trp Thr Gly Pro Asn Cys Glu Arg Lys Lys Pro Pro Val Ile Arg Gln 
        115                 120                 125             


Asn Ile His Ser Leu Ser Pro Gln Glu Arg Glu Gln Phe Leu Gly Ala 
    130                 135                 140                 


Leu Asp Leu Ala Lys Lys Arg Val His Pro Asp Tyr Val Ile Thr Thr 
145                 150                 155                 160 


Gln His Trp Leu Gly Leu Leu Gly Pro Asn Gly Thr Gln Pro Gln Phe 
                165                 170                 175     


Ala Asn Cys Ser Val Tyr Asp Phe Phe Val Trp Leu His Tyr Tyr Ser 
            180                 185                 190         


Val Arg Asp Thr Leu Leu Gly Pro Gly Arg Pro Tyr Arg Ala Ile Asp 
        195                 200                 205             


Phe Ser His Gln Gly Pro Ala Phe Val Thr Trp His Arg Tyr His Leu 
    210                 215                 220                 


Leu Cys Leu Glu Arg Asp Leu Gln Arg Leu Ile Gly Asn Glu Ser Phe 
225                 230                 235                 240 


Ala Leu Pro Tyr Trp Asn Phe Ala Thr Gly Arg Asn Glu Cys Asp Val 
                245                 250                 255     


Cys Thr Asp Gln Leu Phe Gly Ala Ala Arg Pro Asp Asp Pro Thr Leu 
            260                 265                 270         


Ile Ser Arg Asn Ser Arg Phe Ser Ser Trp Glu Thr Val Cys Asp Ser 
        275                 280                 285             


Leu Asp Asp Tyr Asn His Leu Val Thr Leu Cys Asn Gly Thr Tyr Glu 
    290                 295                 300                 


Gly Leu Leu Arg Arg Asn Gln Met Gly Arg Asn Ser Met Lys Leu Pro 
305                 310                 315                 320 


Thr Leu Lys Asp Ile Arg Asp Cys Leu Ser Leu Gln Lys Phe Asp Asn 
                325                 330                 335     


Pro Pro Phe Phe Gln Asn Ser Thr Phe Ser Phe Arg Asn Ala Leu Glu 
            340                 345                 350         


Gly Phe Asp Lys Ala Asp Gly Thr Leu Asp Ser Gln Val Met Ser Leu 
        355                 360                 365             


His Asn Leu Val His Ser Phe Leu Asn Gly Thr Asn Ala Leu Pro His 
    370                 375                 380                 


Ser Ala Ala Asn Asp Pro Ile Phe Val Val Leu His Ser Phe Thr Asp 
385                 390                 395                 400 


Ala Ile Phe Asp Glu Trp Met Lys Arg Phe Asn Pro Pro Ala Asp Ala 
                405                 410                 415     


Trp Pro Gln Glu Leu Ala Pro Ile Gly His Asn Arg Met Tyr Asn Met 
            420                 425                 430         


Val Pro Phe Phe Pro Pro Val Thr Asn Glu Glu Leu Phe Leu Thr Ser 
        435                 440                 445             


Asp Gln Leu Gly Tyr Ser Tyr Ala Ile Asp Leu Pro Val Ser Val Glu 
    450                 455                 460                 


Glu Thr Pro Gly Trp Pro Thr Thr Leu Leu Val Val Met Gly Thr Leu 
465                 470                 475                 480 


Val Ala Leu Val Gly Leu Phe Val Leu Leu Ala Phe Leu Gln Tyr Arg 
                485                 490                 495     


Arg Leu Arg Lys Gly Tyr Thr Pro Leu Met Glu Thr His Leu Ser Ser 
            500                 505                 510         


Lys Arg Tyr Thr Glu Glu Ala 
        515                 


<210>  2502
<211>  1140
<212>  PRT
<213>  Homo sapiens

<400>  2502

Met Ser Tyr Asn Tyr Val Val Thr Ala Gln Lys Pro Thr Ala Val Asn 
1               5                   10                  15      


Gly Cys Val Thr Gly His Phe Thr Ser Ala Glu Asp Leu Asn Leu Leu 
            20                  25                  30          


Ile Ala Lys Asn Thr Arg Leu Glu Ile Tyr Val Val Thr Ala Glu Gly 
        35                  40                  45              


Leu Arg Pro Val Lys Glu Val Gly Met Tyr Gly Lys Ile Ala Val Met 
    50                  55                  60                  


Glu Leu Phe Arg Pro Lys Gly Glu Ser Lys Asp Leu Leu Phe Ile Leu 
65                  70                  75                  80  


Thr Ala Lys Tyr Asn Ala Cys Ile Leu Glu Tyr Lys Gln Ser Gly Glu 
                85                  90                  95      


Ser Ile Asp Ile Ile Thr Arg Ala His Gly Asn Val Gln Asp Arg Ile 
            100                 105                 110         


Gly Arg Pro Ser Glu Thr Gly Ile Ile Gly Ile Ile Asp Pro Glu Cys 
        115                 120                 125             


Arg Met Ile Gly Leu Arg Leu Tyr Asp Gly Leu Phe Lys Val Ile Pro 
    130                 135                 140                 


Leu Asp Arg Asp Asn Lys Glu Leu Lys Ala Phe Asn Ile Arg Leu Glu 
145                 150                 155                 160 


Glu Leu His Val Ile Asp Val Lys Phe Leu Tyr Gly Cys Gln Ala Pro 
                165                 170                 175     


Thr Ile Cys Phe Val Tyr Gln Asp Pro Gln Gly Arg His Val Lys Thr 
            180                 185                 190         


Tyr Glu Val Ser Leu Arg Glu Lys Glu Phe Asn Lys Gly Pro Trp Lys 
        195                 200                 205             


Gln Glu Asn Val Glu Ala Glu Ala Ser Met Val Ile Ala Val Pro Glu 
    210                 215                 220                 


Pro Phe Gly Gly Ala Ile Ile Ile Gly Gln Glu Ser Ile Thr Tyr His 
225                 230                 235                 240 


Asn Gly Asp Lys Tyr Leu Ala Ile Ala Pro Pro Ile Ile Lys Gln Ser 
                245                 250                 255     


Thr Ile Val Cys His Asn Arg Val Asp Pro Asn Gly Ser Arg Tyr Leu 
            260                 265                 270         


Leu Gly Asp Met Glu Gly Arg Leu Phe Met Leu Leu Leu Glu Lys Glu 
        275                 280                 285             


Glu Gln Met Asp Gly Thr Val Thr Leu Lys Asp Leu Arg Val Glu Leu 
    290                 295                 300                 


Leu Gly Glu Thr Ser Ile Ala Glu Cys Leu Thr Tyr Leu Asp Asn Gly 
305                 310                 315                 320 


Val Val Phe Val Gly Ser Arg Leu Gly Asp Ser Gln Leu Val Lys Leu 
                325                 330                 335     


Asn Val Asp Ser Asn Glu Gln Gly Ser Tyr Val Val Ala Met Glu Thr 
            340                 345                 350         


Phe Thr Asn Leu Gly Pro Ile Val Asp Met Cys Val Val Asp Leu Glu 
        355                 360                 365             


Arg Gln Gly Gln Gly Gln Leu Val Thr Cys Ser Gly Ala Phe Lys Glu 
    370                 375                 380                 


Gly Ser Leu Arg Ile Ile Arg Asn Gly Ile Gly Ile His Glu His Ala 
385                 390                 395                 400 


Ser Ile Asp Leu Pro Gly Ile Lys Gly Leu Trp Pro Leu Arg Ser Asp 
                405                 410                 415     


Pro Asn Arg Glu Thr Asp Asp Thr Leu Val Leu Ser Phe Val Gly Gln 
            420                 425                 430         


Thr Arg Val Leu Met Leu Asn Gly Glu Glu Val Glu Glu Thr Glu Leu 
        435                 440                 445             


Met Gly Phe Val Asp Asp Gln Gln Thr Phe Phe Cys Gly Asn Val Ala 
    450                 455                 460                 


His Gln Gln Leu Ile Gln Ile Thr Ser Ala Ser Val Arg Leu Val Ser 
465                 470                 475                 480 


Gln Glu Pro Lys Ala Leu Val Ser Glu Trp Lys Glu Pro Gln Ala Lys 
                485                 490                 495     


Asn Ile Ser Val Ala Ser Cys Asn Ser Ser Gln Val Val Val Ala Val 
            500                 505                 510         


Gly Arg Ala Leu Tyr Tyr Leu Gln Ile His Pro Gln Glu Leu Arg Gln 
        515                 520                 525             


Ile Ser His Thr Glu Met Glu His Glu Val Ala Cys Leu Asp Ile Thr 
    530                 535                 540                 


Pro Leu Gly Asp Ser Asn Gly Leu Ser Pro Leu Cys Ala Ile Gly Leu 
545                 550                 555                 560 


Trp Thr Asp Ile Ser Ala Arg Ile Leu Lys Leu Pro Ser Phe Glu Leu 
                565                 570                 575     


Leu His Lys Glu Met Leu Gly Gly Glu Ile Ile Pro Arg Ser Ile Leu 
            580                 585                 590         


Met Thr Thr Phe Glu Ser Ser His Tyr Leu Leu Cys Ala Leu Gly Asp 
        595                 600                 605             


Gly Ala Leu Phe Tyr Phe Gly Leu Asn Ile Glu Thr Gly Leu Leu Ser 
    610                 615                 620                 


Asp Arg Lys Lys Val Thr Leu Gly Thr Gln Pro Thr Val Leu Arg Thr 
625                 630                 635                 640 


Phe Arg Ser Leu Ser Thr Thr Asn Val Phe Ala Cys Ser Asp Arg Pro 
                645                 650                 655     


Thr Val Ile Tyr Ser Ser Asn His Lys Leu Val Phe Ser Asn Val Asn 
            660                 665                 670         


Leu Lys Glu Val Asn Tyr Met Cys Pro Leu Asn Ser Asp Gly Tyr Pro 
        675                 680                 685             


Asp Ser Leu Ala Leu Ala Asn Asn Ser Thr Leu Thr Ile Gly Thr Ile 
    690                 695                 700                 


Asp Glu Ile Gln Lys Leu His Ile Arg Thr Val Pro Leu Tyr Glu Ser 
705                 710                 715                 720 


Pro Arg Lys Ile Cys Tyr Gln Glu Val Ser Gln Cys Phe Gly Val Leu 
                725                 730                 735     


Ser Ser Arg Ile Glu Val Gln Asp Thr Ser Gly Gly Thr Thr Ala Leu 
            740                 745                 750         


Arg Pro Ser Ala Ser Thr Gln Ala Leu Ser Ser Ser Val Ser Ser Ser 
        755                 760                 765             


Lys Leu Phe Ser Ser Ser Thr Ala Pro His Glu Thr Ser Phe Gly Glu 
    770                 775                 780                 


Glu Val Glu Val His Asn Leu Leu Ile Ile Asp Gln His Thr Phe Glu 
785                 790                 795                 800 


Val Leu His Ala His Gln Phe Leu Gln Asn Glu Tyr Ala Leu Ser Leu 
                805                 810                 815     


Val Ser Cys Lys Leu Gly Lys Asp Pro Asn Thr Tyr Phe Ile Val Gly 
            820                 825                 830         


Thr Ala Met Val Tyr Pro Glu Glu Ala Glu Pro Lys Gln Gly Arg Ile 
        835                 840                 845             


Val Val Phe Gln Tyr Ser Asp Gly Lys Leu Gln Thr Val Ala Glu Lys 
    850                 855                 860                 


Glu Val Lys Gly Ala Val Tyr Ser Met Val Glu Phe Asn Gly Lys Leu 
865                 870                 875                 880 


Leu Ala Ser Ile Asn Ser Thr Val Arg Leu Tyr Glu Trp Thr Thr Glu 
                885                 890                 895     


Lys Glu Leu Arg Thr Glu Cys Asn His Tyr Asn Asn Ile Met Ala Leu 
            900                 905                 910         


Tyr Leu Lys Thr Lys Gly Asp Phe Ile Leu Val Gly Asp Leu Met Arg 
        915                 920                 925             


Ser Val Leu Leu Leu Ala Tyr Lys Pro Met Glu Gly Asn Phe Glu Glu 
    930                 935                 940                 


Ile Ala Arg Asp Phe Asn Pro Asn Trp Met Ser Ala Val Glu Ile Leu 
945                 950                 955                 960 


Asp Asp Asp Asn Phe Leu Gly Ala Glu Asn Ala Phe Asn Leu Phe Val 
                965                 970                 975     


Cys Gln Lys Asp Ser Ala Ala Thr Thr Asp Glu Glu Arg Gln His Leu 
            980                 985                 990         


Gln Glu Val Gly Leu Phe His Leu  Gly Glu Phe Val Asn  Val Phe Cys 
        995                 1000                 1005             


His Gly  Ser Leu Val Met Gln  Asn Leu Gly Glu Thr  Ser Thr Pro 
    1010                 1015                 1020             


Thr Gln  Gly Ser Val Leu Phe  Gly Thr Val Asn Gly  Met Ile Gly 
    1025                 1030                 1035             


Leu Val  Thr Ser Leu Ser Glu  Ser Trp Tyr Asn Leu  Leu Leu Asp 
    1040                 1045                 1050             


Met Gln  Asn Arg Leu Asn Lys  Val Ile Lys Ser Val  Gly Lys Ile 
    1055                 1060                 1065             


Glu His  Ser Phe Trp Arg Ser  Phe His Thr Glu Arg  Lys Thr Glu 
    1070                 1075                 1080             


Pro Ala  Thr Gly Phe Ile Asp  Gly Asp Leu Ile Glu  Ser Phe Leu 
    1085                 1090                 1095             


Asp Ile  Ser Arg Pro Lys Met  Gln Glu Val Val Ala  Asn Leu Gln 
    1100                 1105                 1110             


Tyr Asp  Asp Gly Ser Gly Met  Lys Arg Glu Ala Thr  Ala Asp Asp 
    1115                 1120                 1125             


Leu Ile  Lys Val Val Glu Glu  Leu Thr Arg Ile His  
    1130                 1135                 1140 


<210>  2503
<211>  766
<212>  PRT
<213>  Homo sapiens

<400>  2503

Met Lys Thr Pro Trp Lys Val Leu Leu Gly Leu Leu Gly Ala Ala Ala 
1               5                   10                  15      


Leu Val Thr Ile Ile Thr Val Pro Val Val Leu Leu Asn Lys Gly Thr 
            20                  25                  30          


Asp Asp Ala Thr Ala Asp Ser Arg Lys Thr Tyr Thr Leu Thr Asp Tyr 
        35                  40                  45              


Leu Lys Asn Thr Tyr Arg Leu Lys Leu Tyr Ser Leu Arg Trp Ile Ser 
    50                  55                  60                  


Asp His Glu Tyr Leu Tyr Lys Gln Glu Asn Asn Ile Leu Val Phe Asn 
65                  70                  75                  80  


Ala Glu Tyr Gly Asn Ser Ser Val Phe Leu Glu Asn Ser Thr Phe Asp 
                85                  90                  95      


Glu Phe Gly His Ser Ile Asn Asp Tyr Ser Ile Ser Pro Asp Gly Gln 
            100                 105                 110         


Phe Ile Leu Leu Glu Tyr Asn Tyr Val Lys Gln Trp Arg His Ser Tyr 
        115                 120                 125             


Thr Ala Ser Tyr Asp Ile Tyr Asp Leu Asn Lys Arg Gln Leu Ile Thr 
    130                 135                 140                 


Glu Glu Arg Ile Pro Asn Asn Thr Gln Trp Val Thr Trp Ser Pro Val 
145                 150                 155                 160 


Gly His Lys Leu Ala Tyr Val Trp Asn Asn Asp Ile Tyr Val Lys Ile 
                165                 170                 175     


Glu Pro Asn Leu Pro Ser Tyr Arg Ile Thr Trp Thr Gly Lys Glu Asp 
            180                 185                 190         


Ile Ile Tyr Asn Gly Ile Thr Asp Trp Val Tyr Glu Glu Glu Val Phe 
        195                 200                 205             


Ser Ala Tyr Ser Ala Leu Trp Trp Ser Pro Asn Gly Thr Phe Leu Ala 
    210                 215                 220                 


Tyr Ala Gln Phe Asn Asp Thr Glu Val Pro Leu Ile Glu Tyr Ser Phe 
225                 230                 235                 240 


Tyr Ser Asp Glu Ser Leu Gln Tyr Pro Lys Thr Val Arg Val Pro Tyr 
                245                 250                 255     


Pro Lys Ala Gly Ala Val Asn Pro Thr Val Lys Phe Phe Val Val Asn 
            260                 265                 270         


Thr Asp Ser Leu Ser Ser Val Thr Asn Ala Thr Ser Ile Gln Ile Thr 
        275                 280                 285             


Ala Pro Ala Ser Met Leu Ile Gly Asp His Tyr Leu Cys Asp Val Thr 
    290                 295                 300                 


Trp Ala Thr Gln Glu Arg Ile Ser Leu Gln Trp Leu Arg Arg Ile Gln 
305                 310                 315                 320 


Asn Tyr Ser Val Met Asp Ile Cys Asp Tyr Asp Glu Ser Ser Gly Arg 
                325                 330                 335     


Trp Asn Cys Leu Val Ala Arg Gln His Ile Glu Met Ser Thr Thr Gly 
            340                 345                 350         


Trp Val Gly Arg Phe Arg Pro Ser Glu Pro His Phe Thr Leu Asp Gly 
        355                 360                 365             


Asn Ser Phe Tyr Lys Ile Ile Ser Asn Glu Glu Gly Tyr Arg His Ile 
    370                 375                 380                 


Cys Tyr Phe Gln Ile Asp Lys Lys Asp Cys Thr Phe Ile Thr Lys Gly 
385                 390                 395                 400 


Thr Trp Glu Val Ile Gly Ile Glu Ala Leu Thr Ser Asp Tyr Leu Tyr 
                405                 410                 415     


Tyr Ile Ser Asn Glu Tyr Lys Gly Met Pro Gly Gly Arg Asn Leu Tyr 
            420                 425                 430         


Lys Ile Gln Leu Ser Asp Tyr Thr Lys Val Thr Cys Leu Ser Cys Glu 
        435                 440                 445             


Leu Asn Pro Glu Arg Cys Gln Tyr Tyr Ser Val Ser Phe Ser Lys Glu 
    450                 455                 460                 


Ala Lys Tyr Tyr Gln Leu Arg Cys Ser Gly Pro Gly Leu Pro Leu Tyr 
465                 470                 475                 480 


Thr Leu His Ser Ser Val Asn Asp Lys Gly Leu Arg Val Leu Glu Asp 
                485                 490                 495     


Asn Ser Ala Leu Asp Lys Met Leu Gln Asn Val Gln Met Pro Ser Lys 
            500                 505                 510         


Lys Leu Asp Phe Ile Ile Leu Asn Glu Thr Lys Phe Trp Tyr Gln Met 
        515                 520                 525             


Ile Leu Pro Pro His Phe Asp Lys Ser Lys Lys Tyr Pro Leu Leu Leu 
    530                 535                 540                 


Asp Val Tyr Ala Gly Pro Cys Ser Gln Lys Ala Asp Thr Val Phe Arg 
545                 550                 555                 560 


Leu Asn Trp Ala Thr Tyr Leu Ala Ser Thr Glu Asn Ile Ile Val Ala 
                565                 570                 575     


Ser Phe Asp Gly Arg Gly Ser Gly Tyr Gln Gly Asp Lys Ile Met His 
            580                 585                 590         


Ala Ile Asn Arg Arg Leu Gly Thr Phe Glu Val Glu Asp Gln Ile Glu 
        595                 600                 605             


Ala Ala Arg Gln Phe Ser Lys Met Gly Phe Val Asp Asn Lys Arg Ile 
    610                 615                 620                 


Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Thr Ser Met Val Leu 
625                 630                 635                 640 


Gly Ser Gly Ser Gly Val Phe Lys Cys Gly Ile Ala Val Ala Pro Val 
                645                 650                 655     


Ser Arg Trp Glu Tyr Tyr Asp Ser Val Tyr Thr Glu Arg Tyr Met Gly 
            660                 665                 670         


Leu Pro Thr Pro Glu Asp Asn Leu Asp His Tyr Arg Asn Ser Thr Val 
        675                 680                 685             


Met Ser Arg Ala Glu Asn Phe Lys Gln Val Glu Tyr Leu Leu Ile His 
    690                 695                 700                 


Gly Thr Ala Asp Asp Asn Val His Phe Gln Gln Ser Ala Gln Ile Ser 
705                 710                 715                 720 


Lys Ala Leu Val Asp Val Gly Val Asp Phe Gln Ala Met Trp Tyr Thr 
                725                 730                 735     


Asp Glu Asp His Gly Ile Ala Ser Ser Thr Ala His Gln His Ile Tyr 
            740                 745                 750         


Thr His Met Ser His Phe Ile Lys Gln Cys Phe Ser Leu Pro 
        755                 760                 765     


<210>  2504
<211>  803
<212>  PRT
<213>  Homo sapiens

<400>  2504

Met Thr Thr Ala Lys Glu Pro Ser Ala Ser Gly Lys Ser Val Gln Gln 
1               5                   10                  15      


Gln Glu Gln Glu Leu Val Gly Ser Asn Pro Pro Gln Arg Asn Trp Lys 
            20                  25                  30          


Gly Ile Ala Ile Ala Leu Leu Val Ile Leu Val Ile Cys Ser Leu Ile 
        35                  40                  45              


Val Thr Ser Val Ile Leu Leu Thr Pro Ala Glu Asp Asn Ser Leu Ser 
    50                  55                  60                  


Gln Lys Lys Lys Val Thr Val Glu Asp Leu Phe Ser Glu Asp Phe Lys 
65                  70                  75                  80  


Ile His Asp Pro Glu Ala Lys Trp Ile Ser Asp Thr Glu Phe Ile Tyr 
                85                  90                  95      


Arg Glu Gln Lys Gly Thr Val Arg Leu Trp Asn Val Glu Thr Asn Thr 
            100                 105                 110         


Ser Thr Val Leu Ile Glu Gly Lys Lys Ile Glu Ser Leu Arg Ala Ile 
        115                 120                 125             


Arg Tyr Glu Ile Ser Pro Asp Arg Glu Tyr Ala Leu Phe Ser Tyr Asn 
    130                 135                 140                 


Val Glu Pro Ile Tyr Gln His Ser Tyr Thr Gly Tyr Tyr Val Leu Ser 
145                 150                 155                 160 


Lys Ile Pro His Gly Asp Pro Gln Ser Leu Asp Pro Pro Glu Val Ser 
                165                 170                 175     


Asn Ala Lys Leu Gln Tyr Ala Gly Trp Gly Pro Lys Gly Gln Gln Leu 
            180                 185                 190         


Ile Phe Ile Phe Glu Asn Asn Ile Tyr Tyr Cys Ala His Val Gly Lys 
        195                 200                 205             


Gln Ala Ile Arg Val Val Ser Thr Gly Lys Glu Gly Val Ile Tyr Asn 
    210                 215                 220                 


Gly Leu Ser Asp Trp Leu Tyr Glu Glu Glu Ile Leu Lys Thr His Ile 
225                 230                 235                 240 


Ala His Trp Trp Ser Pro Asp Gly Thr Arg Leu Ala Tyr Ala Ala Ile 
                245                 250                 255     


Asn Asp Ser Arg Val Pro Ile Met Glu Leu Pro Thr Tyr Thr Gly Ser 
            260                 265                 270         


Ile Tyr Pro Thr Val Lys Pro Tyr His Tyr Pro Lys Ala Gly Ser Glu 
        275                 280                 285             


Asn Pro Ser Ile Ser Leu His Val Ile Gly Leu Asn Gly Pro Thr His 
    290                 295                 300                 


Asp Leu Glu Met Met Pro Pro Asp Asp Pro Arg Met Arg Glu Tyr Tyr 
305                 310                 315                 320 


Ile Thr Met Val Lys Trp Ala Thr Ser Thr Lys Val Ala Val Thr Trp 
                325                 330                 335     


Leu Asn Arg Ala Gln Asn Val Ser Ile Leu Thr Leu Cys Asp Ala Thr 
            340                 345                 350         


Thr Gly Val Cys Thr Lys Lys His Glu Asp Glu Ser Glu Ala Trp Leu 
        355                 360                 365             


His Arg Gln Asn Glu Glu Pro Val Phe Ser Lys Asp Gly Arg Lys Phe 
    370                 375                 380                 


Phe Phe Ile Arg Ala Ile Pro Gln Gly Gly Arg Gly Lys Phe Tyr His 
385                 390                 395                 400 


Ile Thr Val Ser Ser Ser Gln Pro Asn Ser Ser Asn Asp Asn Ile Gln 
                405                 410                 415     


Ser Ile Thr Ser Gly Asp Trp Asp Val Thr Lys Ile Leu Ala Tyr Asp 
            420                 425                 430         


Glu Lys Gly Asn Lys Ile Tyr Phe Leu Ser Thr Glu Asp Leu Pro Arg 
        435                 440                 445             


Arg Arg Gln Leu Tyr Ser Ala Asn Thr Val Gly Asn Phe Asn Arg Gln 
    450                 455                 460                 


Cys Leu Ser Cys Asp Leu Val Glu Asn Cys Thr Tyr Phe Ser Ala Ser 
465                 470                 475                 480 


Phe Ser His Ser Met Asp Phe Phe Leu Leu Lys Cys Glu Gly Pro Gly 
                485                 490                 495     


Val Pro Met Val Thr Val His Asn Thr Thr Asp Lys Lys Lys Met Phe 
            500                 505                 510         


Asp Leu Glu Thr Asn Glu His Val Lys Lys Ala Ile Asn Asp Arg Gln 
        515                 520                 525             


Met Pro Lys Val Glu Tyr Arg Asp Ile Glu Ile Asp Asp Tyr Asn Leu 
    530                 535                 540                 


Pro Met Gln Ile Leu Lys Pro Ala Thr Phe Thr Asp Thr Thr His Tyr 
545                 550                 555                 560 


Pro Leu Leu Leu Val Val Asp Gly Thr Pro Gly Ser Gln Ser Val Ala 
                565                 570                 575     


Glu Lys Phe Glu Val Ser Trp Glu Thr Val Met Val Ser Ser His Gly 
            580                 585                 590         


Ala Val Val Val Lys Cys Asp Gly Arg Gly Ser Gly Phe Gln Gly Thr 
        595                 600                 605             


Lys Leu Leu His Glu Val Arg Arg Arg Leu Gly Leu Leu Glu Glu Lys 
    610                 615                 620                 


Asp Gln Met Glu Ala Val Arg Thr Met Leu Lys Glu Gln Tyr Ile Asp 
625                 630                 635                 640 


Arg Thr Arg Val Ala Val Phe Gly Lys Asp Tyr Gly Gly Tyr Leu Ser 
                645                 650                 655     


Thr Tyr Ile Leu Pro Ala Lys Gly Glu Asn Gln Gly Gln Thr Phe Thr 
            660                 665                 670         


Cys Gly Ser Ala Leu Ser Pro Ile Thr Asp Phe Lys Leu Tyr Ala Ser 
        675                 680                 685             


Ala Phe Ser Glu Arg Tyr Leu Gly Leu His Gly Leu Asp Asn Arg Ala 
    690                 695                 700                 


Tyr Glu Met Thr Lys Val Ala His Arg Val Ser Ala Leu Glu Glu Gln 
705                 710                 715                 720 


Gln Phe Leu Ile Ile His Pro Thr Ala Asp Glu Lys Ile His Phe Gln 
                725                 730                 735     


His Thr Ala Glu Leu Ile Thr Gln Leu Ile Arg Gly Lys Ala Asn Tyr 
            740                 745                 750         


Ser Leu Gln Ile Tyr Pro Asp Glu Ser His Tyr Phe Thr Ser Ser Ser 
        755                 760                 765             


Leu Lys Gln His Leu Tyr Arg Ser Ile Ile Asn Phe Phe Val Glu Cys 
    770                 775                 780                 


Phe Arg Ile Gln Asp Lys Leu Leu Thr Val Thr Ala Lys Glu Asp Glu 
785                 790                 795                 800 


Glu Glu Asp 
            


<210>  2505
<211>  896
<212>  PRT
<213>  Homo sapiens

<400>  2505

Met Ala Ala Ala Gly Pro Arg Arg Ser Val Arg Gly Ala Val Cys Leu 
1               5                   10                  15      


His Leu Leu Leu Thr Leu Val Ile Phe Ser Arg Ala Gly Glu Ala Cys 
            20                  25                  30          


Lys Lys Val Ile Leu Asn Val Pro Ser Lys Leu Glu Ala Asp Lys Ile 
        35                  40                  45              


Ile Gly Arg Val Asn Leu Glu Glu Cys Phe Arg Ser Ala Asp Leu Ile 
    50                  55                  60                  


Arg Ser Ser Asp Pro Asp Phe Arg Val Leu Asn Asp Gly Ser Val Tyr 
65                  70                  75                  80  


Thr Ala Arg Ala Val Ala Leu Ser Asp Lys Lys Arg Ser Phe Thr Ile 
                85                  90                  95      


Trp Leu Ser Asp Lys Arg Lys Gln Thr Gln Lys Glu Val Thr Val Leu 
            100                 105                 110         


Leu Glu His Gln Lys Lys Val Ser Lys Thr Arg His Thr Arg Glu Thr 
        115                 120                 125             


Val Leu Arg Arg Ala Lys Arg Arg Trp Ala Pro Ile Pro Cys Ser Met 
    130                 135                 140                 


Gln Glu Asn Ser Leu Gly Pro Phe Pro Leu Phe Leu Gln Gln Val Glu 
145                 150                 155                 160 


Ser Asp Ala Ala Gln Asn Tyr Thr Val Phe Tyr Ser Ile Ser Gly Arg 
                165                 170                 175     


Gly Val Asp Lys Glu Pro Leu Asn Leu Phe Tyr Ile Glu Arg Asp Thr 
            180                 185                 190         


Gly Asn Leu Phe Cys Thr Arg Pro Val Asp Arg Glu Glu Tyr Asp Val 
        195                 200                 205             


Phe Asp Leu Ile Ala Tyr Ala Ser Thr Ala Asp Gly Tyr Ser Ala Asp 
    210                 215                 220                 


Leu Pro Leu Pro Leu Pro Ile Arg Val Glu Asp Glu Asn Asp Asn His 
225                 230                 235                 240 


Pro Val Phe Thr Glu Ala Ile Tyr Asn Phe Glu Val Leu Glu Ser Ser 
                245                 250                 255     


Arg Pro Gly Thr Thr Val Gly Val Val Cys Ala Thr Asp Arg Asp Glu 
            260                 265                 270         


Pro Asp Thr Met His Thr Arg Leu Lys Tyr Ser Ile Leu Gln Gln Thr 
        275                 280                 285             


Pro Arg Ser Pro Gly Leu Phe Ser Val His Pro Ser Thr Gly Val Ile 
    290                 295                 300                 


Thr Thr Val Ser His Tyr Leu Asp Arg Glu Val Val Asp Lys Tyr Ser 
305                 310                 315                 320 


Leu Ile Met Lys Val Gln Asp Met Asp Gly Gln Phe Phe Gly Leu Ile 
                325                 330                 335     


Gly Thr Ser Thr Cys Ile Ile Thr Val Thr Asp Ser Asn Asp Asn Ala 
            340                 345                 350         


Pro Thr Phe Arg Gln Asn Ala Tyr Glu Ala Phe Val Glu Glu Asn Ala 
        355                 360                 365             


Phe Asn Val Glu Ile Leu Arg Ile Pro Ile Glu Asp Lys Asp Leu Ile 
    370                 375                 380                 


Asn Thr Ala Asn Trp Arg Val Asn Phe Thr Ile Leu Lys Gly Asn Glu 
385                 390                 395                 400 


Asn Gly His Phe Lys Ile Ser Thr Asp Lys Glu Thr Asn Glu Gly Val 
                405                 410                 415     


Leu Ser Val Val Lys Pro Leu Asn Tyr Glu Glu Asn Arg Gln Val Asn 
            420                 425                 430         


Leu Glu Ile Gly Val Asn Asn Glu Ala Pro Phe Ala Arg Asp Ile Pro 
        435                 440                 445             


Arg Val Thr Ala Leu Asn Arg Ala Leu Val Thr Val His Val Arg Asp 
    450                 455                 460                 


Leu Asp Glu Gly Pro Glu Cys Thr Pro Ala Ala Gln Tyr Val Arg Ile 
465                 470                 475                 480 


Lys Glu Asn Leu Ala Val Gly Ser Lys Ile Asn Gly Tyr Lys Ala Tyr 
                485                 490                 495     


Asp Pro Glu Asn Arg Asn Gly Asn Gly Leu Arg Tyr Lys Lys Leu His 
            500                 505                 510         


Asp Pro Lys Gly Trp Ile Thr Ile Asp Glu Ile Ser Gly Ser Ile Ile 
        515                 520                 525             


Thr Ser Lys Ile Leu Asp Arg Glu Val Glu Thr Pro Lys Asn Glu Leu 
    530                 535                 540                 


Tyr Asn Ile Thr Val Leu Ala Ile Asp Lys Asp Asp Arg Ser Cys Thr 
545                 550                 555                 560 


Gly Thr Leu Ala Val Asn Ile Glu Asp Val Asn Asp Asn Pro Pro Glu 
                565                 570                 575     


Ile Leu Gln Glu Tyr Val Val Ile Cys Lys Pro Lys Met Gly Tyr Thr 
            580                 585                 590         


Asp Ile Leu Ala Val Asp Pro Asp Glu Pro Val His Gly Ala Pro Phe 
        595                 600                 605             


Tyr Phe Ser Leu Pro Asn Thr Ser Pro Glu Ile Ser Arg Leu Trp Ser 
    610                 615                 620                 


Leu Thr Lys Val Asn Asp Thr Ala Ala Arg Leu Ser Tyr Gln Lys Asn 
625                 630                 635                 640 


Ala Gly Phe Gln Glu Tyr Thr Ile Pro Ile Thr Val Lys Asp Arg Ala 
                645                 650                 655     


Gly Gln Ala Ala Thr Lys Leu Leu Arg Val Asn Leu Cys Glu Cys Thr 
            660                 665                 670         


His Pro Thr Gln Cys Arg Ala Thr Ser Arg Ser Thr Gly Val Ile Leu 
        675                 680                 685             


Gly Lys Trp Ala Ile Leu Ala Ile Leu Leu Gly Ile Ala Leu Leu Phe 
    690                 695                 700                 


Ser Val Leu Leu Thr Leu Val Cys Gly Val Phe Gly Ala Thr Lys Gly 
705                 710                 715                 720 


Lys Arg Phe Pro Glu Asp Leu Ala Gln Gln Asn Leu Ile Ile Ser Asn 
                725                 730                 735     


Thr Glu Ala Pro Gly Asp Asp Arg Val Cys Ser Ala Asn Gly Phe Met 
            740                 745                 750         


Thr Gln Thr Thr Asn Asn Ser Ser Gln Gly Phe Cys Gly Thr Met Gly 
        755                 760                 765             


Ser Gly Met Lys Asn Gly Gly Gln Glu Thr Ile Glu Met Met Lys Gly 
    770                 775                 780                 


Gly Asn Gln Thr Leu Glu Ser Cys Arg Gly Ala Gly His His His Thr 
785                 790                 795                 800 


Leu Asp Ser Cys Arg Gly Gly His Thr Glu Val Asp Asn Cys Arg Tyr 
                805                 810                 815     


Thr Tyr Ser Glu Trp His Ser Phe Thr Gln Pro Arg Leu Gly Glu Lys 
            820                 825                 830         


Leu His Arg Cys Asn Gln Asn Glu Asp Arg Met Pro Ser Gln Asp Tyr 
        835                 840                 845             


Val Leu Thr Tyr Asn Tyr Glu Gly Arg Gly Ser Pro Ala Gly Ser Val 
    850                 855                 860                 


Gly Cys Cys Ser Glu Lys Gln Glu Glu Asp Gly Leu Asp Phe Leu Asn 
865                 870                 875                 880 


Asn Leu Glu Pro Lys Phe Ile Thr Leu Ala Glu Ala Cys Thr Lys Arg 
                885                 890                 895     


<210>  2506
<211>  1118
<212>  PRT
<213>  Homo sapiens

<400>  2506

Met Ala Arg Ser Pro Gly Arg Ala Tyr Ala Leu Leu Leu Leu Leu Ile 
1               5                   10                  15      


Cys Phe Asn Val Gly Ser Gly Leu His Leu Gln Val Leu Ser Thr Arg 
            20                  25                  30          


Asn Glu Asn Lys Leu Leu Pro Lys His Pro His Leu Val Arg Gln Lys 
        35                  40                  45              


Arg Ala Trp Ile Thr Ala Pro Val Ala Leu Arg Glu Gly Glu Asp Leu 
    50                  55                  60                  


Ser Lys Lys Asn Pro Ile Ala Lys Ile His Ser Asp Leu Ala Glu Glu 
65                  70                  75                  80  


Arg Gly Leu Lys Ile Thr Tyr Lys Tyr Thr Gly Lys Gly Ile Thr Glu 
                85                  90                  95      


Pro Pro Phe Gly Ile Phe Val Phe Asn Lys Asp Thr Gly Glu Leu Asn 
            100                 105                 110         


Val Thr Ser Ile Leu Asp Arg Glu Glu Thr Pro Phe Phe Leu Leu Thr 
        115                 120                 125             


Gly Tyr Ala Leu Asp Ala Arg Gly Asn Asn Val Glu Lys Pro Leu Glu 
    130                 135                 140                 


Leu Arg Ile Lys Val Leu Asp Ile Asn Asp Asn Glu Pro Val Phe Thr 
145                 150                 155                 160 


Gln Asp Val Phe Val Gly Ser Val Glu Glu Leu Ser Ala Ala His Thr 
                165                 170                 175     


Leu Val Met Lys Ile Asn Ala Thr Asp Ala Asp Glu Pro Asn Thr Leu 
            180                 185                 190         


Asn Ser Lys Ile Ser Tyr Arg Ile Val Ser Leu Glu Pro Ala Tyr Pro 
        195                 200                 205             


Pro Val Phe Tyr Leu Asn Lys Asp Thr Gly Glu Ile Tyr Thr Thr Ser 
    210                 215                 220                 


Val Thr Leu Asp Arg Glu Glu His Ser Ser Tyr Thr Leu Thr Val Glu 
225                 230                 235                 240 


Ala Arg Asp Gly Asn Gly Glu Val Thr Asp Lys Pro Val Lys Gln Ala 
                245                 250                 255     


Gln Val Gln Ile Arg Ile Leu Asp Val Asn Asp Asn Ile Pro Val Val 
            260                 265                 270         


Glu Asn Lys Val Leu Glu Gly Met Val Glu Glu Asn Gln Val Asn Val 
        275                 280                 285             


Glu Val Thr Arg Ile Lys Val Phe Asp Ala Asp Glu Ile Gly Ser Asp 
    290                 295                 300                 


Asn Trp Leu Ala Asn Phe Thr Phe Ala Ser Gly Asn Glu Gly Gly Tyr 
305                 310                 315                 320 


Phe His Ile Glu Thr Asp Ala Gln Thr Asn Glu Gly Ile Val Thr Leu 
                325                 330                 335     


Ile Lys Glu Val Asp Tyr Glu Glu Met Lys Asn Leu Asp Phe Ser Val 
            340                 345                 350         


Ile Val Ala Asn Lys Ala Ala Phe His Lys Ser Ile Arg Ser Lys Tyr 
        355                 360                 365             


Lys Pro Thr Pro Ile Pro Ile Lys Val Lys Val Lys Asn Val Lys Glu 
    370                 375                 380                 


Gly Ile His Phe Lys Ser Ser Val Ile Ser Ile Tyr Val Ser Glu Ser 
385                 390                 395                 400 


Met Asp Arg Ser Ser Lys Gly Gln Ile Ile Gly Asn Phe Gln Ala Phe 
                405                 410                 415     


Asp Glu Asp Thr Gly Leu Pro Ala His Ala Arg Tyr Val Lys Leu Glu 
            420                 425                 430         


Asp Arg Asp Asn Trp Ile Ser Val Asp Ser Val Thr Ser Glu Ile Lys 
        435                 440                 445             


Leu Ala Lys Leu Pro Asp Phe Glu Ser Arg Tyr Val Gln Asn Gly Thr 
    450                 455                 460                 


Tyr Thr Val Lys Ile Val Ala Ile Ser Glu Asp Tyr Pro Arg Lys Thr 
465                 470                 475                 480 


Ile Thr Gly Thr Val Leu Ile Asn Val Glu Asp Ile Asn Asp Asn Cys 
                485                 490                 495     


Pro Thr Leu Ile Glu Pro Val Gln Thr Ile Cys His Asp Ala Glu Tyr 
            500                 505                 510         


Val Asn Val Thr Ala Glu Asp Leu Asp Gly His Pro Asn Ser Gly Pro 
        515                 520                 525             


Phe Ser Phe Ser Val Ile Asp Lys Pro Pro Gly Met Ala Glu Lys Trp 
    530                 535                 540                 


Lys Ile Ala Arg Gln Glu Ser Thr Ser Val Leu Leu Gln Gln Ser Glu 
545                 550                 555                 560 


Lys Lys Leu Gly Arg Ser Glu Ile Gln Phe Leu Ile Ser Asp Asn Gln 
                565                 570                 575     


Gly Phe Ser Cys Pro Glu Lys Gln Val Leu Thr Leu Thr Val Cys Glu 
            580                 585                 590         


Cys Leu His Gly Ser Gly Cys Arg Glu Ala Gln His Asp Ser Tyr Val 
        595                 600                 605             


Gly Leu Gly Pro Ala Ala Ile Ala Leu Met Ile Leu Ala Phe Leu Leu 
    610                 615                 620                 


Leu Leu Leu Val Pro Leu Leu Leu Leu Met Cys His Cys Gly Lys Gly 
625                 630                 635                 640 


Ala Lys Gly Phe Thr Pro Ile Pro Gly Thr Ile Glu Met Leu His Pro 
                645                 650                 655     


Trp Asn Asn Glu Gly Ala Pro Pro Glu Asp Lys Val Val Pro Ser Phe 
            660                 665                 670         


Leu Pro Val Asp Gln Gly Gly Ser Leu Val Gly Arg Asn Gly Val Gly 
        675                 680                 685             


Gly Met Ala Lys Glu Ala Thr Met Lys Gly Ser Ser Ser Ala Ser Ile 
    690                 695                 700                 


Val Lys Gly Gln His Glu Met Ser Glu Met Asp Gly Arg Trp Glu Glu 
705                 710                 715                 720 


His Arg Ser Leu Leu Ser Gly Arg Ala Thr Gln Phe Thr Gly Ala Thr 
                725                 730                 735     


Gly Ala Ile Met Thr Thr Glu Thr Thr Lys Thr Ala Arg Ala Thr Gly 
            740                 745                 750         


Ala Ser Arg Asp Met Ala Gly Ala Gln Ala Ala Ala Val Ala Leu Asn 
        755                 760                 765             


Glu Glu Phe Leu Arg Asn Tyr Phe Thr Asp Lys Ala Ala Ser Tyr Thr 
    770                 775                 780                 


Glu Glu Asp Glu Asn His Thr Ala Lys Asp Cys Leu Leu Val Tyr Ser 
785                 790                 795                 800 


Gln Glu Glu Thr Glu Ser Leu Asn Ala Ser Ile Gly Cys Cys Ser Phe 
                805                 810                 815     


Ile Glu Gly Glu Leu Asp Asp Arg Phe Leu Asp Asp Leu Gly Leu Lys 
            820                 825                 830         


Phe Lys Thr Leu Ala Glu Val Cys Leu Gly Gln Lys Ile Asp Ile Asn 
        835                 840                 845             


Lys Glu Ile Glu Gln Arg Gln Lys Pro Ala Thr Glu Thr Ser Met Asn 
    850                 855                 860                 


Thr Ala Ser His Ser Leu Cys Glu Gln Thr Met Val Asn Ser Glu Asn 
865                 870                 875                 880 


Thr Tyr Ser Ser Gly Ser Ser Phe Pro Val Pro Lys Ser Leu Gln Glu 
                885                 890                 895     


Ala Asn Ala Glu Lys Val Thr Gln Glu Ile Val Thr Glu Arg Ser Val 
            900                 905                 910         


Ser Ser Arg Gln Ala Gln Lys Val Ala Thr Pro Leu Pro Asp Pro Met 
        915                 920                 925             


Ala Ser Arg Asn Val Ile Ala Thr Glu Thr Ser Tyr Val Thr Gly Ser 
    930                 935                 940                 


Thr Met Pro Pro Thr Thr Val Ile Leu Gly Pro Ser Gln Pro Gln Ser 
945                 950                 955                 960 


Leu Ile Val Thr Glu Arg Val Tyr Ala Pro Ala Ser Thr Leu Val Asp 
                965                 970                 975     


Gln Pro Tyr Ala Asn Glu Gly Thr Val Val Val Thr Glu Arg Val Ile 
            980                 985                 990         


Gln Pro His Gly Gly Gly Ser Asn  Pro Leu Glu Gly Thr  Gln His Leu 
        995                 1000                 1005             


Gln Asp  Val Pro Tyr Val Met  Val Arg Glu Arg Glu  Ser Phe Leu 
    1010                 1015                 1020             


Ala Pro  Ser Ser Gly Val Gln  Pro Thr Leu Ala Met  Pro Asn Ile 
    1025                 1030                 1035             


Ala Val  Gly Gln Asn Val Thr  Val Thr Glu Arg Val  Leu Ala Pro 
    1040                 1045                 1050             


Ala Ser  Thr Leu Gln Ser Ser  Tyr Gln Ile Pro Thr  Glu Asn Ser 
    1055                 1060                 1065             


Met Thr  Ala Arg Asn Thr Thr  Val Ser Gly Ala Gly  Val Pro Gly 
    1070                 1075                 1080             


Pro Leu  Pro Asp Phe Gly Leu  Glu Glu Ser Gly His  Ser Asn Ser 
    1085                 1090                 1095             


Thr Ile  Thr Thr Ser Ser Thr  Arg Val Thr Lys His  Ser Thr Val 
    1100                 1105                 1110             


Gln His  Ser Tyr Ser 
    1115             


<210>  2507
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  2507

Met Lys Leu Leu Pro Ser Val Val Leu Lys Leu Phe Leu Ala Ala Val 
1               5                   10                  15      


Leu Ser Ala Leu Val Thr Gly Glu Ser Leu Glu Arg Leu Arg Arg Gly 
            20                  25                  30          


Leu Ala Ala Gly Thr Ser Asn Pro Asp Pro Pro Thr Val Ser Thr Asp 
        35                  40                  45              


Gln Leu Leu Pro Leu Gly Gly Gly Arg Asp Arg Lys Val Arg Asp Leu 
    50                  55                  60                  


Gln Glu Ala Asp Leu Asp Leu Leu Arg Val Thr Leu Ser Ser Lys Pro 
65                  70                  75                  80  


Gln Ala Leu Ala Thr Pro Asn Lys Glu Glu His Gly Lys Arg Lys Lys 
                85                  90                  95      


Lys Gly Lys Gly Leu Gly Lys Lys Arg Asp Pro Cys Leu Arg Lys Tyr 
            100                 105                 110         


Lys Asp Phe Cys Ile His Gly Glu Cys Lys Tyr Val Lys Glu Leu Arg 
        115                 120                 125             


Ala Pro Ser Cys Ile Cys His Pro Gly Tyr His Gly Glu Arg Cys His 
    130                 135                 140                 


Gly Leu Ser Leu Pro Val Glu Asn Arg Leu Tyr Thr Tyr Asp His Thr 
145                 150                 155                 160 


Thr Ile Leu Ala Val Val Ala Val Val Leu Ser Ser Val Cys Leu Leu 
                165                 170                 175     


Val Ile Val Gly Leu Leu Met Phe Arg Tyr His Arg Arg Gly Gly Tyr 
            180                 185                 190         


Asp Val Glu Asn Glu Glu Lys Val Lys Leu Gly Met Thr Asn Ser His 
        195                 200                 205             


<210>  2508
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  2508

Met Ala Ala Ala Glu Pro Ala Ser Ser Gly Gln Gln Ala Pro Ala Gly 
1               5                   10                  15      


Gln Gly Gln Gly Gln Arg Pro Pro Pro Gln Pro Pro Gln Ala Gln Ala 
            20                  25                  30          


Pro Gln Pro Pro Pro Pro Pro Gln Leu Gly Gly Ala Gly Gly Gly Ser 
        35                  40                  45              


Ser Arg His Glu Lys Ser Leu Gly Leu Leu Thr Thr Lys Phe Val Ser 
    50                  55                  60                  


Leu Leu Gln Glu Ala Lys Asp Gly Val Leu Asp Leu Lys Ala Ala Ala 
65                  70                  75                  80  


Asp Thr Leu Ala Val Arg Gln Lys Arg Arg Ile Tyr Asp Ile Thr Asn 
                85                  90                  95      


Val Leu Glu Gly Ile Asp Leu Ile Glu Lys Lys Ser Lys Asn Ser Ile 
            100                 105                 110         


Gln Trp Lys Gly Val Gly Ala Gly Cys Asn Thr Lys Glu Val Ile Asp 
        115                 120                 125             


Arg Leu Arg Tyr Leu Lys Ala Glu Ile Glu Asp Leu Glu Leu Lys Glu 
    130                 135                 140                 


Arg Glu Leu Asp Gln Gln Lys Leu Trp Leu Gln Gln Ser Ile Lys Asn 
145                 150                 155                 160 


Val Met Asp Asp Ser Ile Asn Asn Arg Phe Ser Tyr Val Thr His Glu 
                165                 170                 175     


Asp Ile Cys Asn Cys Phe Asn Gly Asp Thr Leu Leu Ala Ile Gln Ala 
            180                 185                 190         


Pro Ser Gly Thr Gln Leu Glu Val Pro Ile Pro Glu Met Gly Gln Asn 
        195                 200                 205             


Gly Gln Lys Lys Tyr Gln Ile Asn Leu Lys Ser His Ser Gly Pro Ile 
    210                 215                 220                 


His Val Leu Leu Ile Asn Lys Glu Ser Ser Ser Ser Lys Pro Val Val 
225                 230                 235                 240 


Phe Pro Val Pro Pro Pro Asp Asp Leu Thr Gln Pro Ser Ser Gln Ser 
                245                 250                 255     


Leu Thr Pro Val Thr Pro Gln Lys Ser Ser Met Ala Thr Gln Asn Leu 
            260                 265                 270         


Pro Glu Gln His Val Ser Glu Arg Ser Gln Ala Leu Gln Gln Thr Ser 
        275                 280                 285             


Ala Thr Asp Ile Ser Ser Ala Gly Ser Ile Ser Gly Asp Ile Ile Asp 
    290                 295                 300                 


Glu Leu Met Ser Ser Asp Val Phe Pro Leu Leu Arg Leu Ser Pro Thr 
305                 310                 315                 320 


Pro Ala Asp Asp Tyr Asn Phe Asn Leu Asp Asp Asn Glu Gly Val Cys 
                325                 330                 335     


Asp Leu Phe Asp Val Gln Ile Leu Asn Tyr 
            340                 345     


<210>  2509
<211>  876
<212>  PRT
<213>  Homo sapiens

<400>  2509

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 


Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val 
145                 150                 155                 160 


Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val 
                165                 170                 175     


Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu 
            180                 185                 190         


Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu Ala Val 
        195                 200                 205             


Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Val Gly Gly Leu Gln 
    210                 215                 220                 


Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu Asp Asp 
225                 230                 235                 240 


Phe Arg Lys Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp Tyr Val 
                245                 250                 255     


Gly Trp Ser Asn His Ser Phe Ser Ser Gly Tyr Val Glu Met Glu Phe 
            260                 265                 270         


Glu Phe Asp Arg Leu Arg Ala Phe Gln Ala Met Gln Val His Cys Asn 
        275                 280                 285             


Asn Met His Thr Leu Gly Ala Arg Leu Pro Gly Gly Val Glu Cys Arg 
    290                 295                 300                 


Phe Arg Arg Gly Pro Ala Met Ala Trp Glu Gly Glu Pro Met Arg His 
305                 310                 315                 320 


Asn Leu Gly Gly Asn Leu Gly Asp Pro Arg Ala Arg Ala Val Ser Val 
                325                 330                 335     


Pro Leu Gly Gly Arg Val Ala Arg Phe Leu Gln Cys Arg Phe Leu Phe 
            340                 345                 350         


Ala Gly Pro Trp Leu Leu Phe Ser Glu Ile Ser Phe Ile Ser Asp Val 
        355                 360                 365             


Val Asn Asn Ser Ser Pro Ala Leu Gly Gly Thr Phe Pro Pro Ala Pro 
    370                 375                 380                 


Trp Trp Pro Pro Gly Pro Pro Pro Thr Asn Phe Ser Ser Leu Glu Leu 
385                 390                 395                 400 


Glu Pro Arg Gly Gln Gln Pro Val Ala Lys Ala Glu Gly Ser Pro Thr 
                405                 410                 415     


Ala Ile Leu Ile Gly Cys Leu Val Ala Ile Ile Leu Leu Leu Leu Leu 
            420                 425                 430         


Ile Ile Ala Leu Met Leu Trp Arg Leu His Trp Arg Arg Leu Leu Ser 
        435                 440                 445             


Lys Ala Glu Arg Arg Val Leu Glu Glu Glu Leu Thr Val His Leu Ser 
    450                 455                 460                 


Val Pro Gly Asp Thr Ile Leu Ile Asn Asn Arg Pro Gly Pro Arg Glu 
465                 470                 475                 480 


Pro Pro Pro Tyr Gln Glu Pro Arg Pro Arg Gly Asn Pro Pro His Ser 
                485                 490                 495     


Ala Pro Cys Val Pro Asn Gly Ser Ala Tyr Ser Gly Asp Tyr Met Glu 
            500                 505                 510         


Pro Glu Lys Pro Gly Ala Pro Leu Leu Pro Pro Pro Pro Gln Asn Ser 
        515                 520                 525             


Val Pro His Tyr Ala Glu Ala Asp Ile Val Thr Leu Gln Gly Val Thr 
    530                 535                 540                 


Gly Gly Asn Thr Tyr Ala Val Pro Ala Leu Pro Pro Gly Ala Val Gly 
545                 550                 555                 560 


Asp Gly Pro Pro Arg Val Asp Phe Pro Arg Ser Arg Leu Arg Phe Lys 
                565                 570                 575     


Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu Val His Leu Cys Glu Val 
            580                 585                 590         


Asp Ser Pro Gln Asp Leu Val Ser Leu Asp Phe Pro Leu Asn Val Arg 
        595                 600                 605             


Lys Gly His Pro Leu Leu Val Ala Val Lys Ile Leu Arg Pro Asp Ala 
    610                 615                 620                 


Thr Lys Asn Ala Arg Asn Asp Phe Leu Lys Glu Val Lys Ile Met Ser 
625                 630                 635                 640 


Arg Leu Lys Asp Pro Asn Ile Ile Arg Leu Leu Gly Val Cys Val Gln 
                645                 650                 655     


Asp Asp Pro Leu Cys Met Ile Thr Asp Tyr Met Glu Asn Gly Asp Leu 
            660                 665                 670         


Asn Gln Phe Leu Ser Ala His Gln Leu Glu Asp Lys Ala Ala Glu Gly 
        675                 680                 685             


Ala Pro Gly Asp Gly Gln Ala Ala Gln Gly Pro Thr Ile Ser Tyr Pro 
    690                 695                 700                 


Met Leu Leu His Val Ala Ala Gln Ile Ala Ser Gly Met Arg Tyr Leu 
705                 710                 715                 720 


Ala Thr Leu Asn Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu 
                725                 730                 735     


Val Gly Glu Asn Phe Thr Ile Lys Ile Ala Asp Phe Gly Met Ser Arg 
            740                 745                 750         


Asn Leu Tyr Ala Gly Asp Tyr Tyr Arg Val Gln Gly Arg Ala Val Leu 
        755                 760                 765             


Pro Ile Arg Trp Met Ala Trp Glu Cys Ile Leu Met Gly Lys Phe Thr 
    770                 775                 780                 


Thr Ala Ser Asp Val Trp Ala Phe Gly Val Thr Leu Trp Glu Val Leu 
785                 790                 795                 800 


Met Leu Cys Arg Ala Gln Pro Phe Gly Gln Leu Thr Asp Glu Gln Val 
                805                 810                 815     


Ile Glu Asn Ala Gly Glu Phe Phe Arg Asp Gln Gly Arg Gln Val Tyr 
            820                 825                 830         


Leu Ser Arg Pro Pro Ala Cys Pro Gln Gly Leu Tyr Glu Leu Met Leu 
        835                 840                 845             


Arg Cys Trp Ser Arg Glu Ser Glu Gln Arg Pro Pro Phe Ser Gln Leu 
    850                 855                 860                 


His Arg Phe Leu Ala Glu Asp Ala Leu Asn Thr Val 
865                 870                 875     


<210>  2510
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  2510

Met Glu Thr Leu Cys Leu Arg Ala Ser Phe Trp Leu Ala Leu Val Gly 
1               5                   10                  15      


Cys Val Ile Ser Asp Asn Pro Glu Arg Tyr Ser Thr Asn Leu Ser Asn 
            20                  25                  30          


His Val Asp Asp Phe Thr Thr Phe Arg Gly Thr Glu Leu Ser Phe Leu 
        35                  40                  45              


Val Thr Thr His Gln Pro Thr Asn Leu Val Leu Pro Ser Asn Gly Ser 
    50                  55                  60                  


Met His Asn Tyr Cys Pro Gln Gln Thr Lys Ile Thr Ser Ala Phe Lys 
65                  70                  75                  80  


Tyr Ile Asn Thr Val Ile Ser Cys Thr Ile Phe Ile Val Gly Met Val 
                85                  90                  95      


Gly Asn Ala Thr Leu Leu Arg Ile Ile Tyr Gln Asn Lys Cys Met Arg 
            100                 105                 110         


Asn Gly Pro Asn Ala Leu Ile Ala Ser Leu Ala Leu Gly Asp Leu Ile 
        115                 120                 125             


Tyr Val Val Ile Asp Leu Pro Ile Asn Val Phe Lys Leu Leu Ala Gly 
    130                 135                 140                 


Arg Trp Pro Phe Asp His Asn Asp Phe Gly Val Phe Leu Cys Lys Leu 
145                 150                 155                 160 


Phe Pro Phe Leu Gln Lys Ser Ser Val Gly Ile Thr Val Leu Asn Leu 
                165                 170                 175     


Cys Ala Leu Ser Val Asp Arg Tyr Arg Ala Val Ala Ser Trp Ser Arg 
            180                 185                 190         


Val Gln Gly Ile Gly Ile Pro Leu Val Thr Ala Ile Glu Ile Val Ser 
        195                 200                 205             


Ile Trp Ile Leu Ser Phe Ile Leu Ala Ile Pro Glu Ala Ile Gly Phe 
    210                 215                 220                 


Val Met Val Pro Phe Glu Tyr Arg Gly Glu Gln His Lys Thr Cys Met 
225                 230                 235                 240 


Leu Asn Ala Thr Ser Lys Phe Met Glu Phe Tyr Gln Asp Val Lys Asp 
                245                 250                 255     


Trp Trp Leu Phe Gly Phe Tyr Phe Cys Met Pro Leu Val Cys Thr Ala 
            260                 265                 270         


Ile Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Asn Arg Arg Asn Gly 
        275                 280                 285             


Ser Leu Arg Ile Ala Leu Ser Glu His Leu Lys Gln Arg Arg Glu Val 
    290                 295                 300                 


Ala Lys Thr Val Phe Cys Leu Val Val Ile Phe Ala Leu Cys Trp Phe 
305                 310                 315                 320 


Pro Leu His Leu Ser Arg Ile Leu Lys Lys Thr Val Tyr Asn Glu Met 
                325                 330                 335     


Asp Lys Asn Arg Cys Glu Leu Leu Ser Phe Leu Leu Leu Met Asp Tyr 
            340                 345                 350         


Ile Gly Ile Asn Leu Ala Thr Met Asn Ser Cys Ile Asn Pro Ile Ala 
        355                 360                 365             


Leu Tyr Phe Val Ser Lys Lys Phe Lys Asn Cys Phe Gln Ser Cys Leu 
    370                 375                 380                 


Cys Cys Cys Cys Tyr Gln Ser Lys Ser Leu Met Thr Ser Val Pro Met 
385                 390                 395                 400 


Asn Gly Thr Ser Ile Gln Trp Lys Asn His Asp Gln Asn Asn His Asn 
                405                 410                 415     


Thr Asp Arg Ser Ser His Lys Asp Ser Met Asn 
            420                 425         


<210>  2511
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  2511

Met Leu His Val Glu Met Leu Thr Leu Val Phe Leu Val Leu Trp Met 
1               5                   10                  15      


Cys Val Phe Ser Gln Asp Pro Gly Ser Lys Ala Val Ala Asp Arg Tyr 
            20                  25                  30          


Ala Val Tyr Trp Asn Ser Ser Asn Pro Arg Phe Gln Arg Gly Asp Tyr 
        35                  40                  45              


His Ile Asp Val Cys Ile Asn Asp Tyr Leu Asp Val Phe Cys Pro His 
    50                  55                  60                  


Tyr Glu Asp Ser Val Pro Glu Asp Lys Thr Glu Arg Tyr Val Leu Tyr 
65                  70                  75                  80  


Met Val Asn Phe Asp Gly Tyr Ser Ala Cys Asp His Thr Ser Lys Gly 
                85                  90                  95      


Phe Lys Arg Trp Glu Cys Asn Arg Pro His Ser Pro Asn Gly Pro Leu 
            100                 105                 110         


Lys Phe Ser Glu Lys Phe Gln Leu Phe Thr Pro Phe Ser Leu Gly Phe 
        115                 120                 125             


Glu Phe Arg Pro Gly Arg Glu Tyr Phe Tyr Ile Ser Ser Ala Ile Pro 
    130                 135                 140                 


Asp Asn Gly Arg Arg Ser Cys Leu Lys Leu Lys Val Phe Val Arg Pro 
145                 150                 155                 160 


Thr Asn Ser Cys Met Lys Thr Ile Gly Val His Asp Arg Val Phe Asp 
                165                 170                 175     


Val Asn Asp Lys Val Glu Asn Ser Leu Glu Pro Ala Asp Asp Thr Val 
            180                 185                 190         


His Glu Ser Ala Glu Pro Ser Arg Gly Glu Asn Ala Ala Gln Thr Pro 
        195                 200                 205             


Arg Ile Pro Ser Arg Leu Leu Ala Ile Leu Leu Phe Leu Leu Ala Met 
    210                 215                 220                 


Leu Leu Thr Leu 
225             


<210>  2512
<211>  1207
<212>  PRT
<213>  Homo sapiens

<400>  2512

Met Leu Leu Thr Leu Ile Ile Leu Leu Pro Val Val Ser Lys Phe Ser 
1               5                   10                  15      


Phe Val Ser Leu Ser Ala Pro Gln His Trp Ser Cys Pro Glu Gly Thr 
            20                  25                  30          


Leu Ala Gly Asn Gly Asn Ser Thr Cys Val Gly Pro Ala Pro Phe Leu 
        35                  40                  45              


Ile Phe Ser His Gly Asn Ser Ile Phe Arg Ile Asp Thr Glu Gly Thr 
    50                  55                  60                  


Asn Tyr Glu Gln Leu Val Val Asp Ala Gly Val Ser Val Ile Met Asp 
65                  70                  75                  80  


Phe His Tyr Asn Glu Lys Arg Ile Tyr Trp Val Asp Leu Glu Arg Gln 
                85                  90                  95      


Leu Leu Gln Arg Val Phe Leu Asn Gly Ser Arg Gln Glu Arg Val Cys 
            100                 105                 110         


Asn Ile Glu Lys Asn Val Ser Gly Met Ala Ile Asn Trp Ile Asn Glu 
        115                 120                 125             


Glu Val Ile Trp Ser Asn Gln Gln Glu Gly Ile Ile Thr Val Thr Asp 
    130                 135                 140                 


Met Lys Gly Asn Asn Ser His Ile Leu Leu Ser Ala Leu Lys Tyr Pro 
145                 150                 155                 160 


Ala Asn Val Ala Val Asp Pro Val Glu Arg Phe Ile Phe Trp Ser Ser 
                165                 170                 175     


Glu Val Ala Gly Ser Leu Tyr Arg Ala Asp Leu Asp Gly Val Gly Val 
            180                 185                 190         


Lys Ala Leu Leu Glu Thr Ser Glu Lys Ile Thr Ala Val Ser Leu Asp 
        195                 200                 205             


Val Leu Asp Lys Arg Leu Phe Trp Ile Gln Tyr Asn Arg Glu Gly Ser 
    210                 215                 220                 


Asn Ser Leu Ile Cys Ser Cys Asp Tyr Asp Gly Gly Ser Val His Ile 
225                 230                 235                 240 


Ser Lys His Pro Thr Gln His Asn Leu Phe Ala Met Ser Leu Phe Gly 
                245                 250                 255     


Asp Arg Ile Phe Tyr Ser Thr Trp Lys Met Lys Thr Ile Trp Ile Ala 
            260                 265                 270         


Asn Lys His Thr Gly Lys Asp Met Val Arg Ile Asn Leu His Ser Ser 
        275                 280                 285             


Phe Val Pro Leu Gly Glu Leu Lys Val Val His Pro Leu Ala Gln Pro 
    290                 295                 300                 


Lys Ala Glu Asp Asp Thr Trp Glu Pro Glu Gln Lys Leu Cys Lys Leu 
305                 310                 315                 320 


Arg Lys Gly Asn Cys Ser Ser Thr Val Cys Gly Gln Asp Leu Gln Ser 
                325                 330                 335     


His Leu Cys Met Cys Ala Glu Gly Tyr Ala Leu Ser Arg Asp Arg Lys 
            340                 345                 350         


Tyr Cys Glu Asp Val Asn Glu Cys Ala Phe Trp Asn His Gly Cys Thr 
        355                 360                 365             


Leu Gly Cys Lys Asn Thr Pro Gly Ser Tyr Tyr Cys Thr Cys Pro Val 
    370                 375                 380                 


Gly Phe Val Leu Leu Pro Asp Gly Lys Arg Cys His Gln Leu Val Ser 
385                 390                 395                 400 


Cys Pro Arg Asn Val Ser Glu Cys Ser His Asp Cys Val Leu Thr Ser 
                405                 410                 415     


Glu Gly Pro Leu Cys Phe Cys Pro Glu Gly Ser Val Leu Glu Arg Asp 
            420                 425                 430         


Gly Lys Thr Cys Ser Gly Cys Ser Ser Pro Asp Asn Gly Gly Cys Ser 
        435                 440                 445             


Gln Leu Cys Val Pro Leu Ser Pro Val Ser Trp Glu Cys Asp Cys Phe 
    450                 455                 460                 


Pro Gly Tyr Asp Leu Gln Leu Asp Glu Lys Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Pro Gln Pro Phe Leu Leu Phe Ala Asn Ser Gln Asp Ile Arg His Met 
                485                 490                 495     


His Phe Asp Gly Thr Asp Tyr Gly Thr Leu Leu Ser Gln Gln Met Gly 
            500                 505                 510         


Met Val Tyr Ala Leu Asp His Asp Pro Val Glu Asn Lys Ile Tyr Phe 
        515                 520                 525             


Ala His Thr Ala Leu Lys Trp Ile Glu Arg Ala Asn Met Asp Gly Ser 
    530                 535                 540                 


Gln Arg Glu Arg Leu Ile Glu Glu Gly Val Asp Val Pro Glu Gly Leu 
545                 550                 555                 560 


Ala Val Asp Trp Ile Gly Arg Arg Phe Tyr Trp Thr Asp Arg Gly Lys 
                565                 570                 575     


Ser Leu Ile Gly Arg Ser Asp Leu Asn Gly Lys Arg Ser Lys Ile Ile 
            580                 585                 590         


Thr Lys Glu Asn Ile Ser Gln Pro Arg Gly Ile Ala Val His Pro Met 
        595                 600                 605             


Ala Lys Arg Leu Phe Trp Thr Asp Thr Gly Ile Asn Pro Arg Ile Glu 
    610                 615                 620                 


Ser Ser Ser Leu Gln Gly Leu Gly Arg Leu Val Ile Ala Ser Ser Asp 
625                 630                 635                 640 


Leu Ile Trp Pro Ser Gly Ile Thr Ile Asp Phe Leu Thr Asp Lys Leu 
                645                 650                 655     


Tyr Trp Cys Asp Ala Lys Gln Ser Val Ile Glu Met Ala Asn Leu Asp 
            660                 665                 670         


Gly Ser Lys Arg Arg Arg Leu Thr Gln Asn Asp Val Gly His Pro Phe 
        675                 680                 685             


Ala Val Ala Val Phe Glu Asp Tyr Val Trp Phe Ser Asp Trp Ala Met 
    690                 695                 700                 


Pro Ser Val Met Arg Val Asn Lys Arg Thr Gly Lys Asp Arg Val Arg 
705                 710                 715                 720 


Leu Gln Gly Ser Met Leu Lys Pro Ser Ser Leu Val Val Val His Pro 
                725                 730                 735     


Leu Ala Lys Pro Gly Ala Asp Pro Cys Leu Tyr Gln Asn Gly Gly Cys 
            740                 745                 750         


Glu His Ile Cys Lys Lys Arg Leu Gly Thr Ala Trp Cys Ser Cys Arg 
        755                 760                 765             


Glu Gly Phe Met Lys Ala Ser Asp Gly Lys Thr Cys Leu Ala Leu Asp 
    770                 775                 780                 


Gly His Gln Leu Leu Ala Gly Gly Glu Val Asp Leu Lys Asn Gln Val 
785                 790                 795                 800 


Thr Pro Leu Asp Ile Leu Ser Lys Thr Arg Val Ser Glu Asp Asn Ile 
                805                 810                 815     


Thr Glu Ser Gln His Met Leu Val Ala Glu Ile Met Val Ser Asp Gln 
            820                 825                 830         


Asp Asp Cys Ala Pro Val Gly Cys Ser Met Tyr Ala Arg Cys Ile Ser 
        835                 840                 845             


Glu Gly Glu Asp Ala Thr Cys Gln Cys Leu Lys Gly Phe Ala Gly Asp 
    850                 855                 860                 


Gly Lys Leu Cys Ser Asp Ile Asp Glu Cys Glu Met Gly Val Pro Val 
865                 870                 875                 880 


Cys Pro Pro Ala Ser Ser Lys Cys Ile Asn Thr Glu Gly Gly Tyr Val 
                885                 890                 895     


Cys Arg Cys Ser Glu Gly Tyr Gln Gly Asp Gly Ile His Cys Leu Asp 
            900                 905                 910         


Ile Asp Glu Cys Gln Leu Gly Glu His Ser Cys Gly Glu Asn Ala Ser 
        915                 920                 925             


Cys Thr Asn Thr Glu Gly Gly Tyr Thr Cys Met Cys Ala Gly Arg Leu 
    930                 935                 940                 


Ser Glu Pro Gly Leu Ile Cys Pro Asp Ser Thr Pro Pro Pro His Leu 
945                 950                 955                 960 


Arg Glu Asp Asp His His Tyr Ser Val Arg Asn Ser Asp Ser Glu Cys 
                965                 970                 975     


Pro Leu Ser His Asp Gly Tyr Cys Leu His Asp Gly Val Cys Met Tyr 
            980                 985                 990         


Ile Glu Ala Leu Asp Lys Tyr Ala  Cys Asn Cys Val Val  Gly Tyr Ile 
        995                 1000                 1005             


Gly Glu  Arg Cys Gln Tyr Arg  Asp Leu Lys Trp Trp  Glu Leu Arg 
    1010                 1015                 1020             


His Ala  Gly His Gly Gln Gln  Gln Lys Val Ile Val  Val Ala Val 
    1025                 1030                 1035             


Cys Val  Val Val Leu Val Met  Leu Leu Leu Leu Ser  Leu Trp Gly 
    1040                 1045                 1050             


Ala His  Tyr Tyr Arg Thr Gln  Lys Leu Leu Ser Lys  Asn Pro Lys 
    1055                 1060                 1065             


Asn Pro  Tyr Glu Glu Ser Ser  Arg Asp Val Arg Ser  Arg Arg Pro 
    1070                 1075                 1080             


Ala Asp  Thr Glu Asp Gly Met  Ser Ser Cys Pro Gln  Pro Trp Phe 
    1085                 1090                 1095             


Val Val  Ile Lys Glu His Gln  Asp Leu Lys Asn Gly  Gly Gln Pro 
    1100                 1105                 1110             


Val Ala  Gly Glu Asp Gly Gln  Ala Ala Asp Gly Ser  Met Gln Pro 
    1115                 1120                 1125             


Thr Ser  Trp Arg Gln Glu Pro  Gln Leu Cys Gly Met  Gly Thr Glu 
    1130                 1135                 1140             


Gln Gly  Cys Trp Ile Pro Val  Ser Ser Asp Lys Gly  Ser Cys Pro 
    1145                 1150                 1155             


Gln Val  Met Glu Arg Ser Phe  His Met Pro Ser Tyr  Gly Thr Gln 
    1160                 1165                 1170             


Thr Leu  Glu Gly Gly Val Glu  Lys Pro His Ser Leu  Leu Ser Ala 
    1175                 1180                 1185             


Asn Pro  Leu Trp Gln Gln Arg  Ala Leu Asp Pro Pro  His Gln Met 
    1190                 1195                 1200             


Glu Leu  Thr Gln 
    1205         


<210>  2513
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  2513

Met Thr Leu Gly Arg Arg Leu Ala Cys Leu Phe Leu Ala Cys Val Leu 
1               5                   10                  15      


Pro Ala Leu Leu Leu Gly Gly Thr Ala Leu Ala Ser Glu Ile Val Gly 
            20                  25                  30          


Gly Arg Arg Ala Arg Pro His Ala Trp Pro Phe Met Val Ser Leu Gln 
        35                  40                  45              


Leu Arg Gly Gly His Phe Cys Gly Ala Thr Leu Ile Ala Pro Asn Phe 
    50                  55                  60                  


Val Met Ser Ala Ala His Cys Val Ala Asn Val Asn Val Arg Ala Val 
65                  70                  75                  80  


Arg Val Val Leu Gly Ala His Asn Leu Ser Arg Arg Glu Pro Thr Arg 
                85                  90                  95      


Gln Val Phe Ala Val Gln Arg Ile Phe Glu Asn Gly Tyr Asp Pro Val 
            100                 105                 110         


Asn Leu Leu Asn Asp Ile Val Ile Leu Gln Leu Asn Gly Ser Ala Thr 
        115                 120                 125             


Ile Asn Ala Asn Val Gln Val Ala Gln Leu Pro Ala Gln Gly Arg Arg 
    130                 135                 140                 


Leu Gly Asn Gly Val Gln Cys Leu Ala Met Gly Trp Gly Leu Leu Gly 
145                 150                 155                 160 


Arg Asn Arg Gly Ile Ala Ser Val Leu Gln Glu Leu Asn Val Thr Val 
                165                 170                 175     


Val Thr Ser Leu Cys Arg Arg Ser Asn Val Cys Thr Leu Val Arg Gly 
            180                 185                 190         


Arg Gln Ala Gly Val Cys Phe Gly Asp Ser Gly Ser Pro Leu Val Cys 
        195                 200                 205             


Asn Gly Leu Ile His Gly Ile Ala Ser Phe Val Arg Gly Gly Cys Ala 
    210                 215                 220                 


Ser Gly Leu Tyr Pro Asp Ala Phe Ala Pro Val Ala Gln Phe Val Asn 
225                 230                 235                 240 


Trp Ile Asp Ser Ile Ile Gln Arg Ser Glu Asp Asn Pro Cys Pro His 
                245                 250                 255     


Pro Arg Asp Pro Asp Pro Ala Ser Arg Thr His 
            260                 265         


<210>  2514
<211>  886
<212>  PRT
<213>  Homo sapiens

<400>  2514

Met Arg Gly Phe Asn Leu Leu Leu Phe Trp Gly Cys Cys Val Met His 
1               5                   10                  15      


Ser Trp Glu Gly His Ile Arg Pro Thr Arg Lys Pro Asn Thr Lys Gly 
            20                  25                  30          


Asn Asn Cys Arg Asp Ser Thr Leu Cys Pro Ala Tyr Ala Thr Cys Thr 
        35                  40                  45              


Asn Thr Val Asp Ser Tyr Tyr Cys Ala Cys Lys Gln Gly Phe Leu Ser 
    50                  55                  60                  


Ser Asn Gly Gln Asn His Phe Lys Asp Pro Gly Val Arg Cys Lys Asp 
65                  70                  75                  80  


Ile Asp Glu Cys Ser Gln Ser Pro Gln Pro Cys Gly Pro Asn Ser Ser 
                85                  90                  95      


Cys Lys Asn Leu Ser Gly Arg Tyr Lys Cys Ser Cys Leu Asp Gly Phe 
            100                 105                 110         


Ser Ser Pro Thr Gly Asn Asp Trp Val Pro Gly Lys Pro Gly Asn Phe 
        115                 120                 125             


Ser Cys Thr Asp Ile Asn Glu Cys Leu Thr Ser Ser Val Cys Pro Glu 
    130                 135                 140                 


His Ser Asp Cys Val Asn Ser Met Gly Ser Tyr Ser Cys Ser Cys Gln 
145                 150                 155                 160 


Val Gly Phe Ile Ser Arg Asn Ser Thr Cys Glu Asp Val Asp Glu Cys 
                165                 170                 175     


Ala Asp Pro Arg Ala Cys Pro Glu His Ala Thr Cys Asn Asn Thr Val 
            180                 185                 190         


Gly Asn Tyr Ser Cys Phe Cys Asn Pro Gly Phe Glu Ser Ser Ser Gly 
        195                 200                 205             


His Leu Ser Phe Gln Gly Leu Lys Ala Ser Cys Glu Asp Ile Asp Glu 
    210                 215                 220                 


Cys Thr Glu Met Cys Pro Ile Asn Ser Thr Cys Thr Asn Thr Pro Gly 
225                 230                 235                 240 


Ser Tyr Phe Cys Thr Cys His Pro Gly Phe Ala Pro Ser Asn Gly Gln 
                245                 250                 255     


Leu Asn Phe Thr Asp Gln Gly Val Glu Cys Arg Asp Ile Asp Glu Cys 
            260                 265                 270         


Arg Gln Asp Pro Ser Thr Cys Gly Pro Asn Ser Ile Cys Thr Asn Ala 
        275                 280                 285             


Leu Gly Ser Tyr Ser Cys Gly Cys Ile Ala Gly Phe His Pro Asn Pro 
    290                 295                 300                 


Glu Gly Ser Gln Lys Asp Gly Asn Phe Ser Cys Gln Arg Val Leu Phe 
305                 310                 315                 320 


Lys Cys Lys Glu Asp Val Ile Pro Asp Asn Lys Gln Ile Gln Gln Cys 
                325                 330                 335     


Gln Glu Gly Thr Ala Val Lys Pro Ala Tyr Val Ser Phe Cys Ala Gln 
            340                 345                 350         


Ile Asn Asn Ile Phe Ser Val Leu Asp Lys Val Cys Glu Asn Lys Thr 
        355                 360                 365             


Thr Val Val Ser Leu Lys Asn Thr Thr Glu Ser Phe Val Pro Val Leu 
    370                 375                 380                 


Lys Gln Ile Ser Thr Trp Thr Lys Phe Thr Lys Glu Glu Thr Ser Ser 
385                 390                 395                 400 


Leu Ala Thr Val Phe Leu Glu Ser Val Glu Ser Met Thr Leu Ala Ser 
                405                 410                 415     


Phe Trp Lys Pro Ser Ala Asn Ile Thr Pro Ala Val Arg Thr Glu Tyr 
            420                 425                 430         


Leu Asp Ile Glu Ser Lys Val Ile Asn Lys Glu Cys Ser Glu Glu Asn 
        435                 440                 445             


Val Thr Leu Asp Leu Val Ala Lys Gly Asp Lys Met Lys Ile Gly Cys 
    450                 455                 460                 


Ser Thr Ile Glu Glu Ser Glu Ser Thr Glu Thr Thr Gly Val Ala Phe 
465                 470                 475                 480 


Val Ser Phe Val Gly Met Glu Ser Val Leu Asn Glu Arg Phe Phe Lys 
                485                 490                 495     


Asp His Gln Ala Pro Leu Thr Thr Ser Glu Ile Lys Leu Lys Met Asn 
            500                 505                 510         


Ser Arg Val Val Gly Gly Ile Met Thr Gly Glu Lys Lys Asp Gly Phe 
        515                 520                 525             


Ser Asp Pro Ile Ile Tyr Thr Leu Glu Asn Ile Gln Pro Lys Gln Lys 
    530                 535                 540                 


Phe Glu Arg Pro Ile Cys Val Ser Trp Ser Thr Asp Val Lys Gly Gly 
545                 550                 555                 560 


Arg Trp Thr Ser Phe Gly Cys Val Ile Leu Glu Ala Ser Glu Thr Tyr 
                565                 570                 575     


Thr Ile Cys Ser Cys Asn Gln Met Ala Asn Leu Ala Val Ile Met Ala 
            580                 585                 590         


Ser Gly Glu Leu Thr Met Asp Phe Ser Leu Tyr Ile Ile Ser His Val 
        595                 600                 605             


Gly Ile Ile Ile Ser Leu Val Cys Leu Val Leu Ala Ile Ala Thr Phe 
    610                 615                 620                 


Leu Leu Cys Arg Ser Ile Arg Asn His Asn Thr Tyr Leu His Leu His 
625                 630                 635                 640 


Leu Cys Val Cys Leu Leu Leu Ala Lys Thr Leu Phe Leu Ala Gly Ile 
                645                 650                 655     


His Lys Thr Asp Asn Lys Met Gly Cys Ala Ile Ile Ala Gly Phe Leu 
            660                 665                 670         


His Tyr Leu Phe Leu Ala Cys Phe Phe Trp Met Leu Val Glu Ala Val 
        675                 680                 685             


Ile Leu Phe Leu Met Val Arg Asn Leu Lys Val Val Asn Tyr Phe Ser 
    690                 695                 700                 


Ser Arg Asn Ile Lys Met Leu His Ile Cys Ala Phe Gly Tyr Gly Leu 
705                 710                 715                 720 


Pro Met Leu Val Val Val Ile Ser Ala Ser Val Gln Pro Gln Gly Tyr 
                725                 730                 735     


Gly Met His Asn Arg Cys Trp Leu Asn Thr Glu Thr Gly Phe Ile Trp 
            740                 745                 750         


Ser Phe Leu Gly Pro Val Cys Thr Val Ile Val Ile Asn Ser Leu Leu 
        755                 760                 765             


Leu Thr Trp Thr Leu Trp Ile Leu Arg Gln Arg Leu Ser Ser Val Asn 
    770                 775                 780                 


Ala Glu Val Ser Thr Leu Lys Asp Thr Arg Leu Leu Thr Phe Lys Ala 
785                 790                 795                 800 


Phe Ala Gln Leu Phe Ile Leu Gly Cys Ser Trp Val Leu Gly Ile Phe 
                805                 810                 815     


Gln Ile Gly Pro Val Ala Gly Val Met Ala Tyr Leu Phe Thr Ile Ile 
            820                 825                 830         


Asn Ser Leu Gln Gly Ala Phe Ile Phe Leu Ile His Cys Leu Leu Asn 
        835                 840                 845             


Gly Gln Val Arg Glu Glu Tyr Lys Arg Trp Ile Thr Gly Lys Thr Lys 
    850                 855                 860                 


Pro Ser Ser Gln Ser Gln Thr Ser Arg Ile Leu Leu Ser Ser Met Pro 
865                 870                 875                 880 


Ser Ala Ser Lys Thr Gly 
                885     


<210>  2515
<211>  957
<212>  PRT
<213>  Homo sapiens

<400>  2515

Met Asn Phe Ala Glu Arg Glu Gly Ser Lys Arg Tyr Cys Ile Gln Thr 
1               5                   10                  15      


Lys His Val Ala Ile Leu Cys Ala Val Val Val Gly Val Gly Leu Ile 
            20                  25                  30          


Val Gly Leu Ala Val Gly Leu Thr Arg Ser Cys Asp Ser Ser Gly Asp 
        35                  40                  45              


Gly Gly Pro Gly Thr Ala Pro Ala Pro Ser His Leu Pro Ser Ser Thr 
    50                  55                  60                  


Ala Ser Pro Ser Gly Pro Pro Ala Gln Asp Gln Asp Ile Cys Pro Ala 
65                  70                  75                  80  


Ser Glu Asp Glu Ser Gly Gln Trp Lys Asn Phe Arg Leu Pro Asp Phe 
                85                  90                  95      


Val Asn Pro Val His Tyr Asp Leu His Val Lys Pro Leu Leu Glu Glu 
            100                 105                 110         


Asp Thr Tyr Thr Gly Thr Val Ser Ile Ser Ile Asn Leu Ser Ala Pro 
        115                 120                 125             


Thr Arg Tyr Leu Trp Leu His Leu Arg Glu Thr Arg Ile Thr Arg Leu 
    130                 135                 140                 


Pro Glu Leu Lys Arg Pro Ser Gly Asp Gln Val Gln Val Arg Arg Cys 
145                 150                 155                 160 


Phe Glu Tyr Lys Lys Gln Glu Tyr Val Val Val Glu Ala Glu Glu Glu 
                165                 170                 175     


Leu Thr Pro Ser Ser Gly Asp Gly Leu Tyr Leu Leu Thr Met Glu Phe 
            180                 185                 190         


Ala Gly Trp Leu Asn Gly Ser Leu Val Gly Phe Tyr Arg Thr Thr Tyr 
        195                 200                 205             


Thr Glu Asn Gly Gln Val Lys Ser Ile Val Ala Thr Asp His Glu Pro 
    210                 215                 220                 


Thr Asp Ala Arg Lys Ser Phe Pro Cys Phe Asp Glu Pro Asn Lys Lys 
225                 230                 235                 240 


Ala Thr Tyr Thr Ile Ser Ile Thr His Pro Lys Glu Tyr Gly Ala Leu 
                245                 250                 255     


Ser Asn Met Pro Val Ala Lys Glu Glu Ser Val Asp Asp Lys Trp Thr 
            260                 265                 270         


Arg Thr Thr Phe Glu Lys Ser Val Pro Met Ser Thr Tyr Leu Val Cys 
        275                 280                 285             


Phe Ala Val His Gln Phe Asp Ser Val Lys Arg Ile Ser Asn Ser Gly 
    290                 295                 300                 


Lys Pro Leu Thr Ile Tyr Val Gln Pro Glu Gln Lys His Thr Ala Glu 
305                 310                 315                 320 


Tyr Ala Ala Asn Ile Thr Lys Ser Val Phe Asp Tyr Phe Glu Glu Tyr 
                325                 330                 335     


Phe Ala Met Asn Tyr Ser Leu Pro Lys Leu Asp Lys Ile Ala Ile Pro 
            340                 345                 350         


Asp Phe Gly Thr Gly Ala Met Glu Asn Trp Gly Leu Ile Thr Tyr Arg 
        355                 360                 365             


Glu Thr Asn Leu Leu Tyr Asp Pro Lys Glu Ser Ala Ser Ser Asn Gln 
    370                 375                 380                 


Gln Arg Val Ala Thr Val Val Ala His Glu Leu Val His Gln Trp Phe 
385                 390                 395                 400 


Gly Asn Ile Val Thr Met Asp Trp Trp Glu Asp Leu Trp Leu Asn Glu 
                405                 410                 415     


Gly Phe Ala Ser Phe Phe Glu Phe Leu Gly Val Asn His Ala Glu Thr 
            420                 425                 430         


Asp Trp Gln Met Arg Asp Gln Met Leu Leu Glu Asp Val Leu Pro Val 
        435                 440                 445             


Gln Glu Asp Asp Ser Leu Met Ser Ser His Pro Ile Ile Val Thr Val 
    450                 455                 460                 


Thr Thr Pro Asp Glu Ile Thr Ser Val Phe Asp Gly Ile Ser Tyr Ser 
465                 470                 475                 480 


Lys Gly Ser Ser Ile Leu Arg Met Leu Glu Asp Trp Ile Lys Pro Glu 
                485                 490                 495     


Asn Phe Gln Lys Gly Cys Gln Met Tyr Leu Glu Lys Tyr Gln Phe Lys 
            500                 505                 510         


Asn Ala Lys Thr Ser Asp Phe Trp Ala Ala Leu Glu Glu Ala Ser Arg 
        515                 520                 525             


Leu Pro Val Lys Glu Val Met Asp Thr Trp Thr Arg Gln Met Gly Tyr 
    530                 535                 540                 


Pro Val Leu Asn Val Asn Gly Val Lys Asn Ile Thr Gln Lys Arg Phe 
545                 550                 555                 560 


Leu Leu Asp Pro Arg Ala Asn Pro Ser Gln Pro Pro Ser Asp Leu Gly 
                565                 570                 575     


Tyr Thr Trp Asn Ile Pro Val Lys Trp Thr Glu Asp Asn Ile Thr Ser 
            580                 585                 590         


Ser Val Leu Phe Asn Arg Ser Glu Lys Glu Gly Ile Thr Leu Asn Ser 
        595                 600                 605             


Ser Asn Pro Ser Gly Asn Ala Phe Leu Lys Ile Asn Pro Asp His Ile 
    610                 615                 620                 


Gly Phe Tyr Arg Val Asn Tyr Glu Val Ala Thr Trp Asp Ser Ile Ala 
625                 630                 635                 640 


Thr Ala Leu Ser Leu Asn His Lys Thr Phe Ser Ser Ala Asp Arg Ala 
                645                 650                 655     


Ser Leu Ile Asp Asp Ala Phe Ala Leu Ala Arg Ala Gln Leu Leu Asp 
            660                 665                 670         


Tyr Lys Val Ala Leu Asn Leu Thr Lys Tyr Leu Lys Arg Glu Glu Asn 
        675                 680                 685             


Phe Leu Pro Trp Gln Arg Val Ile Ser Ala Val Thr Tyr Ile Ile Ser 
    690                 695                 700                 


Met Phe Glu Asp Asp Lys Glu Leu Tyr Pro Met Ile Glu Glu Tyr Phe 
705                 710                 715                 720 


Gln Gly Gln Val Lys Pro Ile Ala Asp Ser Leu Gly Trp Asn Asp Ala 
                725                 730                 735     


Gly Asp His Val Thr Lys Leu Leu Arg Ser Ser Val Leu Gly Phe Ala 
            740                 745                 750         


Cys Lys Met Gly Asp Arg Glu Ala Leu Asn Asn Ala Ser Ser Leu Phe 
        755                 760                 765             


Glu Gln Trp Leu Asn Gly Thr Val Ser Leu Pro Val Asn Leu Arg Leu 
    770                 775                 780                 


Leu Val Tyr Arg Tyr Gly Met Gln Asn Ser Gly Asn Glu Ile Ser Trp 
785                 790                 795                 800 


Asn Tyr Thr Leu Glu Gln Tyr Gln Lys Thr Ser Leu Ala Gln Glu Lys 
                805                 810                 815     


Glu Lys Leu Leu Tyr Gly Leu Ala Ser Val Lys Asn Val Thr Leu Leu 
            820                 825                 830         


Ser Arg Tyr Leu Asp Leu Leu Lys Asp Thr Asn Leu Ile Lys Thr Gln 
        835                 840                 845             


Asp Val Phe Thr Val Ile Arg Tyr Ile Ser Tyr Asn Ser Tyr Gly Lys 
    850                 855                 860                 


Asn Met Ala Trp Asn Trp Ile Gln Leu Asn Trp Asp Tyr Leu Val Asn 
865                 870                 875                 880 


Arg Tyr Thr Leu Asn Asn Arg Asn Leu Gly Arg Ile Val Thr Ile Ala 
                885                 890                 895     


Glu Pro Phe Asn Thr Glu Leu Gln Leu Trp Gln Met Glu Ser Phe Phe 
            900                 905                 910         


Ala Lys Tyr Pro Gln Ala Gly Ala Gly Glu Lys Pro Arg Glu Gln Val 
        915                 920                 925             


Leu Glu Thr Val Lys Asn Asn Ile Glu Trp Leu Lys Gln His Arg Asn 
    930                 935                 940                 


Thr Ile Arg Glu Trp Phe Phe Asn Leu Leu Glu Ser Gly 
945                 950                 955         


<210>  2516
<211>  287
<212>  PRT
<213>  Homo sapiens

<400>  2516

Met Arg Asp Arg Leu Pro Asp Leu Thr Ala Cys Arg Lys Asn Asp Asp 
1               5                   10                  15      


Gly Asp Thr Val Val Val Val Glu Lys Asp His Phe Met Asp Asp Phe 
            20                  25                  30          


Phe His Gln Val Glu Glu Ile Arg Asn Ser Ile Asp Lys Ile Thr Gln 
        35                  40                  45              


Tyr Val Glu Glu Val Lys Lys Asn His Ser Ile Ile Leu Ser Ala Pro 
    50                  55                  60                  


Asn Pro Glu Gly Lys Ile Lys Glu Glu Leu Glu Asp Leu Asn Lys Glu 
65                  70                  75                  80  


Ile Lys Lys Thr Ala Asn Lys Ile Arg Ala Lys Leu Lys Ala Ile Glu 
                85                  90                  95      


Gln Ser Phe Asp Gln Asp Glu Ser Gly Asn Arg Thr Ser Val Asp Leu 
            100                 105                 110         


Arg Ile Arg Arg Thr Gln His Ser Val Leu Ser Arg Lys Phe Val Glu 
        115                 120                 125             


Ala Met Ala Glu Tyr Asn Glu Ala Gln Thr Leu Phe Arg Glu Arg Ser 
    130                 135                 140                 


Lys Gly Arg Ile Gln Arg Gln Leu Glu Ile Thr Gly Arg Thr Thr Thr 
145                 150                 155                 160 


Asp Asp Glu Leu Glu Glu Met Leu Glu Ser Gly Lys Pro Ser Ile Phe 
                165                 170                 175     


Thr Ser Asp Ile Ile Ser Asp Ser Gln Ile Thr Arg Gln Ala Leu Asn 
            180                 185                 190         


Glu Ile Glu Ser Arg His Lys Asp Ile Met Lys Leu Glu Thr Ser Ile 
        195                 200                 205             


Arg Glu Leu His Glu Met Phe Met Asp Met Ala Met Phe Val Glu Thr 
    210                 215                 220                 


Gln Gly Glu Met Ile Asn Asn Ile Glu Arg Asn Val Met Asn Ala Thr 
225                 230                 235                 240 


Asp Tyr Val Glu His Ala Lys Glu Glu Thr Lys Lys Ala Ile Lys Tyr 
                245                 250                 255     


Gln Ser Lys Ala Arg Arg Lys Leu Met Phe Ile Ile Ile Cys Val Ile 
            260                 265                 270         


Val Leu Leu Val Ile Leu Gly Ile Ile Leu Ala Thr Thr Leu Ser 
        275                 280                 285         


<210>  2517
<211>  1342
<212>  PRT
<213>  Homo sapiens

<400>  2517

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser 
                325                 330                 335     


Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val 
            340                 345                 350         


Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
        355                 360                 365             


Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu 
    370                 375                 380                 


Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 
385                 390                 395                 400 


Ser Trp Pro Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr 
                405                 410                 415     


Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 
            420                 425                 430         


Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu 
        435                 440                 445             


Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr 
    450                 455                 460                 


His His Ser Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu 
465                 470                 475                 480 


Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu 
                485                 490                 495     


Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro 
            500                 505                 510         


Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val 
        515                 520                 525             


Cys Val Thr His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala 
    530                 535                 540                 


His Glu Ala Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu 
545                 550                 555                 560 


Gly Thr Ala Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys 
                565                 570                 575     


Ala His Phe Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly 
            580                 585                 590         


Val Leu Gly Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn 
        595                 600                 605             


Glu Cys Arg Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro 
    610                 615                 620                 


Glu Leu Gln Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr 
625                 630                 635                 640 


His Leu Thr Met Ala Leu Thr Val Ile Ala Gly Leu Val Val Ile Phe 
                645                 650                 655     


Met Met Leu Gly Gly Thr Phe Leu Tyr Trp Arg Gly Arg Arg Ile Gln 
            660                 665                 670         


Asn Lys Arg Ala Met Arg Arg Tyr Leu Glu Arg Gly Glu Ser Ile Glu 
        675                 680                 685             


Pro Leu Asp Pro Ser Glu Lys Ala Asn Lys Val Leu Ala Arg Ile Phe 
    690                 695                 700                 


Lys Glu Thr Glu Leu Arg Lys Leu Lys Val Leu Gly Ser Gly Val Phe 
705                 710                 715                 720 


Gly Thr Val His Lys Gly Val Trp Ile Pro Glu Gly Glu Ser Ile Lys 
                725                 730                 735     


Ile Pro Val Cys Ile Lys Val Ile Glu Asp Lys Ser Gly Arg Gln Ser 
            740                 745                 750         


Phe Gln Ala Val Thr Asp His Met Leu Ala Ile Gly Ser Leu Asp His 
        755                 760                 765             


Ala His Ile Val Arg Leu Leu Gly Leu Cys Pro Gly Ser Ser Leu Gln 
    770                 775                 780                 


Leu Val Thr Gln Tyr Leu Pro Leu Gly Ser Leu Leu Asp His Val Arg 
785                 790                 795                 800 


Gln His Arg Gly Ala Leu Gly Pro Gln Leu Leu Leu Asn Trp Gly Val 
                805                 810                 815     


Gln Ile Ala Lys Gly Met Tyr Tyr Leu Glu Glu His Gly Met Val His 
            820                 825                 830         


Arg Asn Leu Ala Ala Arg Asn Val Leu Leu Lys Ser Pro Ser Gln Val 
        835                 840                 845             


Gln Val Ala Asp Phe Gly Val Ala Asp Leu Leu Pro Pro Asp Asp Lys 
    850                 855                 860                 


Gln Leu Leu Tyr Ser Glu Ala Lys Thr Pro Ile Lys Trp Met Ala Leu 
865                 870                 875                 880 


Glu Ser Ile His Phe Gly Lys Tyr Thr His Gln Ser Asp Val Trp Ser 
                885                 890                 895     


Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ala Glu Pro Tyr 
            900                 905                 910         


Ala Gly Leu Arg Leu Ala Glu Val Pro Asp Leu Leu Glu Lys Gly Glu 
        915                 920                 925             


Arg Leu Ala Gln Pro Gln Ile Cys Thr Ile Asp Val Tyr Met Val Met 
    930                 935                 940                 


Val Lys Cys Trp Met Ile Asp Glu Asn Ile Arg Pro Thr Phe Lys Glu 
945                 950                 955                 960 


Leu Ala Asn Glu Phe Thr Arg Met Ala Arg Asp Pro Pro Arg Tyr Leu 
                965                 970                 975     


Val Ile Lys Arg Glu Ser Gly Pro Gly Ile Ala Pro Gly Pro Glu Pro 
            980                 985                 990         


His Gly Leu Thr Asn Lys Lys Leu  Glu Glu Val Glu Leu  Glu Pro Glu 
        995                 1000                 1005             


Leu Asp  Leu Asp Leu Asp Leu  Glu Ala Glu Glu Asp  Asn Leu Ala 
    1010                 1015                 1020             


Thr Thr  Thr Leu Gly Ser Ala  Leu Ser Leu Pro Val  Gly Thr Leu 
    1025                 1030                 1035             


Asn Arg  Pro Arg Gly Ser Gln  Ser Leu Leu Ser Pro  Ser Ser Gly 
    1040                 1045                 1050             


Tyr Met  Pro Met Asn Gln Gly  Asn Leu Gly Glu Ser  Cys Gln Glu 
    1055                 1060                 1065             


Ser Ala  Val Ser Gly Ser Ser  Glu Arg Cys Pro Arg  Pro Val Ser 
    1070                 1075                 1080             


Leu His  Pro Met Pro Arg Gly  Cys Leu Ala Ser Glu  Ser Ser Glu 
    1085                 1090                 1095             


Gly His  Val Thr Gly Ser Glu  Ala Glu Leu Gln Glu  Lys Val Ser 
    1100                 1105                 1110             


Met Cys  Arg Ser Arg Ser Arg  Ser Arg Ser Pro Arg  Pro Arg Gly 
    1115                 1120                 1125             


Asp Ser  Ala Tyr His Ser Gln  Arg His Ser Leu Leu  Thr Pro Val 
    1130                 1135                 1140             


Thr Pro  Leu Ser Pro Pro Gly  Leu Glu Glu Glu Asp  Val Asn Gly 
    1145                 1150                 1155             


Tyr Val  Met Pro Asp Thr His  Leu Lys Gly Thr Pro  Ser Ser Arg 
    1160                 1165                 1170             


Glu Gly  Thr Leu Ser Ser Val  Gly Leu Ser Ser Val  Leu Gly Thr 
    1175                 1180                 1185             


Glu Glu  Glu Asp Glu Asp Glu  Glu Tyr Glu Tyr Met  Asn Arg Arg 
    1190                 1195                 1200             


Arg Arg  His Ser Pro Pro His  Pro Pro Arg Pro Ser  Ser Leu Glu 
    1205                 1210                 1215             


Glu Leu  Gly Tyr Glu Tyr Met  Asp Val Gly Ser Asp  Leu Ser Ala 
    1220                 1225                 1230             


Ser Leu  Gly Ser Thr Gln Ser  Cys Pro Leu His Pro  Val Pro Ile 
    1235                 1240                 1245             


Met Pro  Thr Ala Gly Thr Thr  Pro Asp Glu Asp Tyr  Glu Tyr Met 
    1250                 1255                 1260             


Asn Arg  Gln Arg Asp Gly Gly  Gly Pro Gly Gly Asp  Tyr Ala Ala 
    1265                 1270                 1275             


Met Gly  Ala Cys Pro Ala Ser  Glu Gln Gly Tyr Glu  Glu Met Arg 
    1280                 1285                 1290             


Ala Phe  Gln Gly Pro Gly His  Gln Ala Pro His Val  His Tyr Ala 
    1295                 1300                 1305             


Arg Leu  Lys Thr Leu Arg Ser  Leu Glu Ala Thr Asp  Ser Ala Phe 
    1310                 1315                 1320             


Asp Asn  Pro Asp Tyr Trp His  Ser Arg Leu Phe Pro  Lys Ala Asn 
    1325                 1330                 1335             


Ala Gln  Arg Thr 
    1340         


<210>  2518
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  2518

Met Ser Glu Thr Pro Ala Gln Cys Ser Ile Lys Gln Glu Arg Ile Ser 
1               5                   10                  15      


Tyr Thr Pro Pro Glu Ser Pro Val Pro Ser Tyr Ala Ser Ser Thr Pro 
            20                  25                  30          


Leu His Val Pro Val Pro Arg Ala Leu Arg Met Glu Glu Asp Ser Ile 
        35                  40                  45              


Arg Leu Pro Ala His Leu Arg Leu Gln Pro Ile Tyr Trp Ser Arg Asp 
    50                  55                  60                  


Asp Val Ala Gln Trp Leu Lys Trp Ala Glu Asn Glu Phe Ser Leu Arg 
65                  70                  75                  80  


Pro Ile Asp Ser Asn Thr Phe Glu Met Asn Gly Lys Ala Leu Leu Leu 
                85                  90                  95      


Leu Thr Lys Glu Asp Phe Arg Tyr Arg Ser Pro His Ser Gly Asp Val 
            100                 105                 110         


Leu Tyr Glu Leu Leu Gln His Ile Leu Lys Gln Arg Lys Pro Arg Ile 
        115                 120                 125             


Leu Phe Ser Pro Phe Phe His Pro Gly Asn Ser Ile His Thr Gln Pro 
    130                 135                 140                 


Glu Val Ile Leu His Gln Asn His Glu Glu Asp Asn Cys Val Gln Arg 
145                 150                 155                 160 


Thr Pro Arg Pro Ser Val Asp Asn Val His His Asn Pro Pro Thr Ile 
                165                 170                 175     


Glu Leu Leu His Arg Ser Arg Ser Pro Ile Thr Thr Asn His Arg Pro 
            180                 185                 190         


Ser Pro Asp Pro Glu Gln Arg Pro Leu Arg Ser Pro Leu Asp Asn Met 
        195                 200                 205             


Ile Arg Arg Leu Ser Pro Ala Glu Arg Ala Gln Gly Pro Arg Pro His 
    210                 215                 220                 


Gln Glu Asn Asn His Gln Glu Ser Tyr Pro Leu Ser Val Ser Pro Met 
225                 230                 235                 240 


Glu Asn Asn His Cys Pro Ala Ser Ser Glu Ser His Pro Lys Pro Ser 
                245                 250                 255     


Ser Pro Arg Gln Glu Ser Thr Arg Val Ile Gln Leu Met Pro Ser Pro 
            260                 265                 270         


Ile Met His Pro Leu Ile Leu Asn Pro Arg His Ser Val Asp Phe Lys 
        275                 280                 285             


Gln Ser Arg Leu Ser Glu Asp Gly Leu His Arg Glu Gly Lys Pro Ile 
    290                 295                 300                 


Asn Leu Ser His Arg Glu Asp Leu Ala Tyr Met Asn His Ile Met Val 
305                 310                 315                 320 


Ser Val Ser Pro Pro Glu Glu His Ala Met Pro Ile Gly Arg Ile Ala 
                325                 330                 335     


Asp Cys Arg Leu Leu Trp Asp Tyr Val Tyr Gln Leu Leu Ser Asp Ser 
            340                 345                 350         


Arg Tyr Glu Asn Phe Ile Arg Trp Glu Asp Lys Glu Ser Lys Ile Phe 
        355                 360                 365             


Arg Ile Val Asp Pro Asn Gly Leu Ala Arg Leu Trp Gly Asn His Lys 
    370                 375                 380                 


Asn Arg Thr Asn Met Thr Tyr Glu Lys Met Ser Arg Ala Leu Arg His 
385                 390                 395                 400 


Tyr Tyr Lys Leu Asn Ile Ile Arg Lys Glu Pro Gly Gln Arg Leu Leu 
                405                 410                 415     


Phe Arg Phe Met Lys Thr Pro Asp Glu Ile Met Ser Gly Arg Thr Asp 
            420                 425                 430         


Arg Leu Glu His Leu Glu Ser Gln Glu Leu Asp Glu Gln Ile Tyr Gln 
        435                 440                 445             


Glu Asp Glu Cys 
    450         


<210>  2519
<211>  425
<212>  PRT
<213>  Homo sapiens

<400>  2519

Met Gly Pro Arg Arg Leu Leu Leu Val Ala Ala Cys Phe Ser Leu Cys 
1               5                   10                  15      


Gly Pro Leu Leu Ser Ala Arg Thr Arg Ala Arg Arg Pro Glu Ser Lys 
            20                  25                  30          


Ala Thr Asn Ala Thr Leu Asp Pro Arg Ser Phe Leu Leu Arg Asn Pro 
        35                  40                  45              


Asn Asp Lys Tyr Glu Pro Phe Trp Glu Asp Glu Glu Lys Asn Glu Ser 
    50                  55                  60                  


Gly Leu Thr Glu Tyr Arg Leu Val Ser Ile Asn Lys Ser Ser Pro Leu 
65                  70                  75                  80  


Gln Lys Gln Leu Pro Ala Phe Ile Ser Glu Asp Ala Ser Gly Tyr Leu 
                85                  90                  95      


Thr Ser Ser Trp Leu Thr Leu Phe Val Pro Ser Val Tyr Thr Gly Val 
            100                 105                 110         


Phe Val Val Ser Leu Pro Leu Asn Ile Met Ala Ile Val Val Phe Ile 
        115                 120                 125             


Leu Lys Met Lys Val Lys Lys Pro Ala Val Val Tyr Met Leu His Leu 
    130                 135                 140                 


Ala Thr Ala Asp Val Leu Phe Val Ser Val Leu Pro Phe Lys Ile Ser 
145                 150                 155                 160 


Tyr Tyr Phe Ser Gly Ser Asp Trp Gln Phe Gly Ser Glu Leu Cys Arg 
                165                 170                 175     


Phe Val Thr Ala Ala Phe Tyr Cys Asn Met Tyr Ala Ser Ile Leu Leu 
            180                 185                 190         


Met Thr Val Ile Ser Ile Asp Arg Phe Leu Ala Val Val Tyr Pro Met 
        195                 200                 205             


Gln Ser Leu Ser Trp Arg Thr Leu Gly Arg Ala Ser Phe Thr Cys Leu 
    210                 215                 220                 


Ala Ile Trp Ala Leu Ala Ile Ala Gly Val Val Pro Leu Leu Leu Lys 
225                 230                 235                 240 


Glu Gln Thr Ile Gln Val Pro Gly Leu Asn Ile Thr Thr Cys His Asp 
                245                 250                 255     


Val Leu Asn Glu Thr Leu Leu Glu Gly Tyr Tyr Ala Tyr Tyr Phe Ser 
            260                 265                 270         


Ala Phe Ser Ala Val Phe Phe Phe Val Pro Leu Ile Ile Ser Thr Val 
        275                 280                 285             


Cys Tyr Val Ser Ile Ile Arg Cys Leu Ser Ser Ser Ala Val Ala Asn 
    290                 295                 300                 


Arg Ser Lys Lys Ser Arg Ala Leu Phe Leu Ser Ala Ala Val Phe Cys 
305                 310                 315                 320 


Ile Phe Ile Ile Cys Phe Gly Pro Thr Asn Val Leu Leu Ile Ala His 
                325                 330                 335     


Tyr Ser Phe Leu Ser His Thr Ser Thr Thr Glu Ala Ala Tyr Phe Ala 
            340                 345                 350         


Tyr Leu Leu Cys Val Cys Val Ser Ser Ile Ser Cys Cys Ile Asp Pro 
        355                 360                 365             


Leu Ile Tyr Tyr Tyr Ala Ser Ser Glu Cys Gln Arg Tyr Val Tyr Ser 
    370                 375                 380                 


Ile Leu Cys Cys Lys Glu Ser Ser Asp Pro Ser Ser Tyr Asn Ser Ser 
385                 390                 395                 400 


Gly Gln Leu Met Ala Ser Lys Met Asp Thr Cys Ser Ser Asn Leu Asn 
                405                 410                 415     


Asn Ser Ile Tyr Lys Lys Leu Leu Thr 
            420                 425 


<210>  2520
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  2520

Met Glu Thr Pro Ala Trp Pro Arg Val Pro Arg Pro Glu Thr Ala Val 
1               5                   10                  15      


Ala Arg Thr Leu Leu Leu Gly Trp Val Phe Ala Gln Val Ala Gly Ala 
            20                  25                  30          


Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser 
        35                  40                  45              


Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln 
    50                  55                  60                  


Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys 
65                  70                  75                  80  


Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val 
                85                  90                  95      


Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala 
            100                 105                 110         


Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn 
        115                 120                 125             


Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr 
    130                 135                 140                 


Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu 
145                 150                 155                 160 


Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg 
                165                 170                 175     


Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser 
            180                 185                 190         


Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu 
        195                 200                 205             


Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val 
    210                 215                 220                 


Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu 
225                 230                 235                 240 


Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Ile Phe Tyr Ile Ile 
                245                 250                 255     


Gly Ala Val Val Phe Val Val Ile Ile Leu Val Ile Ile Leu Ala Ile 
            260                 265                 270         


Ser Leu His Lys Cys Arg Lys Ala Gly Val Gly Gln Ser Trp Lys Glu 
        275                 280                 285             


Asn Ser Pro Leu Asn Val Ser 
    290                 295 


<210>  2521
<211>  698
<212>  PRT
<213>  Homo sapiens

<400>  2521

Met Gln Ala His Glu Leu Phe Arg Tyr Phe Arg Met Pro Glu Leu Val 
1               5                   10                  15      


Asp Phe Arg Gln Tyr Val Arg Thr Leu Pro Thr Asn Thr Leu Met Gly 
            20                  25                  30          


Phe Gly Ala Phe Ala Ala Leu Thr Thr Phe Trp Tyr Ala Thr Arg Pro 
        35                  40                  45              


Lys Pro Leu Lys Pro Pro Cys Asp Leu Ser Met Gln Ser Val Glu Val 
    50                  55                  60                  


Ala Gly Ser Gly Gly Ala Arg Arg Ser Ala Leu Leu Asp Ser Asp Glu 
65                  70                  75                  80  


Pro Leu Val Tyr Phe Tyr Asp Asp Val Thr Thr Leu Tyr Glu Gly Phe 
                85                  90                  95      


Gln Arg Gly Ile Gln Val Ser Asn Asn Gly Pro Cys Leu Gly Ser Arg 
            100                 105                 110         


Lys Pro Asp Gln Pro Tyr Glu Trp Leu Ser Tyr Lys Gln Val Ala Glu 
        115                 120                 125             


Leu Ser Glu Cys Ile Gly Ser Ala Leu Ile Gln Lys Gly Phe Lys Thr 
    130                 135                 140                 


Ala Pro Asp Gln Phe Ile Gly Ile Phe Ala Gln Asn Arg Pro Glu Trp 
145                 150                 155                 160 


Val Ile Ile Glu Gln Gly Cys Phe Ala Tyr Ser Met Val Ile Val Pro 
                165                 170                 175     


Leu Tyr Asp Thr Leu Gly Asn Glu Ala Ile Thr Tyr Ile Val Asn Lys 
            180                 185                 190         


Ala Glu Leu Ser Leu Val Phe Val Asp Lys Pro Glu Lys Ala Lys Leu 
        195                 200                 205             


Leu Leu Glu Gly Val Glu Asn Lys Leu Ile Pro Gly Leu Lys Ile Ile 
    210                 215                 220                 


Val Val Met Asp Ala Tyr Gly Ser Glu Leu Val Glu Arg Gly Gln Arg 
225                 230                 235                 240 


Cys Gly Val Glu Val Thr Ser Met Lys Ala Met Glu Asp Leu Gly Arg 
                245                 250                 255     


Ala Asn Arg Arg Lys Pro Lys Pro Pro Ala Pro Glu Asp Leu Ala Val 
            260                 265                 270         


Ile Cys Phe Thr Ser Gly Thr Thr Gly Asn Pro Lys Gly Ala Met Val 
        275                 280                 285             


Thr His Arg Asn Ile Val Ser Asp Cys Ser Ala Phe Val Lys Ala Thr 
    290                 295                 300                 


Glu Asn Thr Val Asn Pro Cys Pro Asp Asp Thr Leu Ile Ser Phe Leu 
305                 310                 315                 320 


Pro Leu Ala His Met Phe Glu Arg Val Val Glu Cys Val Met Leu Cys 
                325                 330                 335     


His Gly Ala Lys Ile Gly Phe Phe Gln Gly Asp Ile Arg Leu Leu Met 
            340                 345                 350         


Asp Asp Leu Lys Val Leu Gln Pro Thr Val Phe Pro Val Val Pro Arg 
        355                 360                 365             


Leu Leu Asn Arg Met Phe Asp Arg Ile Phe Gly Gln Ala Asn Thr Thr 
    370                 375                 380                 


Leu Lys Arg Trp Leu Leu Asp Phe Ala Ser Lys Arg Lys Glu Ala Glu 
385                 390                 395                 400 


Leu Arg Ser Gly Ile Ile Arg Asn Asn Ser Leu Trp Asp Arg Leu Ile 
                405                 410                 415     


Phe His Lys Val Gln Ser Ser Leu Gly Gly Arg Val Arg Leu Met Val 
            420                 425                 430         


Thr Gly Ala Ala Pro Val Ser Ala Thr Val Leu Thr Phe Leu Arg Ala 
        435                 440                 445             


Ala Leu Gly Cys Gln Phe Tyr Glu Gly Tyr Gly Gln Thr Glu Cys Thr 
    450                 455                 460                 


Ala Gly Cys Cys Leu Thr Met Pro Gly Asp Trp Thr Ala Gly His Val 
465                 470                 475                 480 


Gly Ala Pro Met Pro Cys Asn Leu Ile Lys Leu Val Asp Val Glu Glu 
                485                 490                 495     


Met Asn Tyr Met Ala Ala Glu Gly Glu Gly Glu Val Cys Val Lys Gly 
            500                 505                 510         


Pro Asn Val Phe Gln Gly Tyr Leu Lys Asp Pro Ala Lys Thr Ala Glu 
        515                 520                 525             


Ala Leu Asp Lys Asp Gly Trp Leu His Thr Gly Asp Ile Gly Lys Trp 
    530                 535                 540                 


Leu Pro Asn Gly Thr Leu Lys Ile Ile Asp Arg Lys Lys His Ile Phe 
545                 550                 555                 560 


Lys Leu Ala Gln Gly Glu Tyr Ile Ala Pro Glu Lys Ile Glu Asn Ile 
                565                 570                 575     


Tyr Met Arg Ser Glu Pro Val Ala Gln Val Phe Val His Gly Glu Ser 
            580                 585                 590         


Leu Gln Ala Phe Leu Ile Ala Ile Val Val Pro Asp Val Glu Thr Leu 
        595                 600                 605             


Cys Ser Trp Ala Gln Lys Arg Gly Phe Glu Gly Ser Phe Glu Glu Leu 
    610                 615                 620                 


Cys Arg Asn Lys Asp Val Lys Lys Ala Ile Leu Glu Asp Met Val Arg 
625                 630                 635                 640 


Leu Gly Lys Asp Ser Gly Leu Lys Pro Phe Glu Gln Val Lys Gly Ile 
                645                 650                 655     


Thr Leu His Pro Glu Leu Phe Ser Ile Asp Asn Gly Leu Leu Thr Pro 
            660                 665                 670         


Thr Met Lys Ala Lys Arg Pro Glu Leu Arg Asn Tyr Phe Arg Ser Gln 
        675                 680                 685             


Ile Asp Asp Leu Tyr Ser Thr Ile Lys Val 
    690                 695             


<210>  2522
<211>  2912
<212>  PRT
<213>  Homo sapiens

<400>  2522

Met Gly Arg Arg Arg Arg Leu Cys Leu Gln Leu Tyr Phe Leu Trp Leu 
1               5                   10                  15      


Gly Cys Val Val Leu Trp Ala Gln Gly Thr Ala Gly Gln Pro Gln Pro 
            20                  25                  30          


Pro Pro Pro Lys Pro Pro Arg Pro Gln Pro Pro Pro Gln Gln Val Arg 
        35                  40                  45              


Ser Ala Thr Ala Gly Ser Glu Gly Gly Phe Leu Ala Pro Glu Tyr Arg 
    50                  55                  60                  


Glu Glu Gly Ala Ala Val Ala Ser Arg Val Arg Arg Arg Gly Gln Gln 
65                  70                  75                  80  


Asp Val Leu Arg Gly Pro Asn Val Cys Gly Ser Arg Phe His Ser Tyr 
                85                  90                  95      


Cys Cys Pro Gly Trp Lys Thr Leu Pro Gly Gly Asn Gln Cys Ile Val 
            100                 105                 110         


Pro Ile Cys Arg Asn Ser Cys Gly Asp Gly Phe Cys Ser Arg Pro Asn 
        115                 120                 125             


Met Cys Thr Cys Ser Ser Gly Gln Ile Ser Ser Thr Cys Gly Ser Lys 
    130                 135                 140                 


Ser Ile Gln Gln Cys Ser Val Arg Cys Met Asn Gly Gly Thr Cys Ala 
145                 150                 155                 160 


Asp Asp His Cys Gln Cys Gln Lys Gly Tyr Ile Gly Thr Tyr Cys Gly 
                165                 170                 175     


Gln Pro Val Cys Glu Asn Gly Cys Gln Asn Gly Gly Arg Cys Ile Gly 
            180                 185                 190         


Pro Asn Arg Cys Ala Cys Val Tyr Gly Phe Thr Gly Pro Gln Cys Glu 
        195                 200                 205             


Arg Asp Tyr Arg Thr Gly Pro Cys Phe Thr Gln Val Asn Asn Gln Met 
    210                 215                 220                 


Cys Gln Gly Gln Leu Thr Gly Ile Val Cys Thr Lys Thr Leu Cys Cys 
225                 230                 235                 240 


Ala Thr Ile Gly Arg Ala Trp Gly His Pro Cys Glu Met Cys Pro Ala 
                245                 250                 255     


Gln Pro Gln Pro Cys Arg Arg Gly Phe Ile Pro Asn Ile Arg Thr Gly 
            260                 265                 270         


Ala Cys Gln Asp Val Asp Glu Cys Gln Ala Ile Pro Gly Ile Cys Gln 
        275                 280                 285             


Gly Gly Asn Cys Ile Asn Thr Val Gly Ser Phe Glu Cys Arg Cys Pro 
    290                 295                 300                 


Ala Gly His Lys Gln Ser Glu Thr Thr Gln Lys Cys Glu Asp Ile Asp 
305                 310                 315                 320 


Glu Cys Ser Ile Ile Pro Gly Ile Cys Glu Thr Gly Glu Cys Ser Asn 
                325                 330                 335     


Thr Val Gly Ser Tyr Phe Cys Val Cys Pro Arg Gly Tyr Val Thr Ser 
            340                 345                 350         


Thr Asp Gly Ser Arg Cys Ile Asp Gln Arg Thr Gly Met Cys Phe Ser 
        355                 360                 365             


Gly Leu Val Asn Gly Arg Cys Ala Gln Glu Leu Pro Gly Arg Met Thr 
    370                 375                 380                 


Lys Met Gln Cys Cys Cys Glu Pro Gly Arg Cys Trp Gly Ile Gly Thr 
385                 390                 395                 400 


Ile Pro Glu Ala Cys Pro Val Arg Gly Ser Glu Glu Tyr Arg Arg Leu 
                405                 410                 415     


Cys Met Asp Gly Leu Pro Met Gly Gly Ile Pro Gly Ser Ala Gly Ser 
            420                 425                 430         


Arg Pro Gly Gly Thr Gly Gly Asn Gly Phe Ala Pro Ser Gly Asn Gly 
        435                 440                 445             


Asn Gly Tyr Gly Pro Gly Gly Thr Gly Phe Ile Pro Ile Pro Gly Gly 
    450                 455                 460                 


Asn Gly Phe Ser Pro Gly Val Gly Gly Ala Gly Val Gly Ala Gly Gly 
465                 470                 475                 480 


Gln Gly Pro Ile Ile Thr Gly Leu Thr Ile Leu Asn Gln Thr Ile Asp 
                485                 490                 495     


Ile Cys Lys His His Ala Asn Leu Cys Leu Asn Gly Arg Cys Ile Pro 
            500                 505                 510         


Thr Val Ser Ser Tyr Arg Cys Glu Cys Asn Met Gly Tyr Lys Gln Asp 
        515                 520                 525             


Ala Asn Gly Asp Cys Ile Asp Val Asp Glu Cys Thr Ser Asn Pro Cys 
    530                 535                 540                 


Thr Asn Gly Asp Cys Val Asn Thr Pro Gly Ser Tyr Tyr Cys Lys Cys 
545                 550                 555                 560 


His Ala Gly Phe Gln Arg Thr Pro Thr Lys Gln Ala Cys Ile Asp Ile 
                565                 570                 575     


Asp Glu Cys Ile Gln Asn Gly Val Leu Cys Lys Asn Gly Arg Cys Val 
            580                 585                 590         


Asn Thr Asp Gly Ser Phe Gln Cys Ile Cys Asn Ala Gly Phe Glu Leu 
        595                 600                 605             


Thr Thr Asp Gly Lys Asn Cys Val Asp His Asp Glu Cys Thr Thr Thr 
    610                 615                 620                 


Asn Met Cys Leu Asn Gly Met Cys Ile Asn Glu Asp Gly Ser Phe Lys 
625                 630                 635                 640 


Cys Ile Cys Lys Pro Gly Phe Val Leu Ala Pro Asn Gly Arg Tyr Cys 
                645                 650                 655     


Thr Asp Val Asp Glu Cys Gln Thr Pro Gly Ile Cys Met Asn Gly His 
            660                 665                 670         


Cys Ile Asn Ser Glu Gly Ser Phe Arg Cys Asp Cys Pro Pro Gly Leu 
        675                 680                 685             


Ala Val Gly Met Asp Gly Arg Val Cys Val Asp Thr His Met Arg Ser 
    690                 695                 700                 


Thr Cys Tyr Gly Gly Ile Lys Lys Gly Val Cys Val Arg Pro Phe Pro 
705                 710                 715                 720 


Gly Ala Val Thr Lys Ser Glu Cys Cys Cys Ala Asn Pro Asp Tyr Gly 
                725                 730                 735     


Phe Gly Glu Pro Cys Gln Pro Cys Pro Ala Lys Asn Ser Ala Glu Phe 
            740                 745                 750         


His Gly Leu Cys Ser Ser Gly Val Gly Ile Thr Val Asp Gly Arg Asp 
        755                 760                 765             


Ile Asn Glu Cys Ala Leu Asp Pro Asp Ile Cys Ala Asn Gly Ile Cys 
    770                 775                 780                 


Glu Asn Leu Arg Gly Ser Tyr Arg Cys Asn Cys Asn Ser Gly Tyr Glu 
785                 790                 795                 800 


Pro Asp Ala Ser Gly Arg Asn Cys Ile Asp Ile Asp Glu Cys Leu Val 
                805                 810                 815     


Asn Arg Leu Leu Cys Asp Asn Gly Leu Cys Arg Asn Thr Pro Gly Ser 
            820                 825                 830         


Tyr Ser Cys Thr Cys Pro Pro Gly Tyr Val Phe Arg Thr Glu Thr Glu 
        835                 840                 845             


Thr Cys Glu Asp Ile Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly 
    850                 855                 860                 


Ala Cys Arg Asn Asn Leu Gly Ser Phe Asn Cys Glu Cys Ser Pro Gly 
865                 870                 875                 880 


Ser Lys Leu Ser Ser Thr Gly Leu Ile Cys Ile Asp Ser Leu Lys Gly 
                885                 890                 895     


Thr Cys Trp Leu Asn Ile Gln Asp Ser Arg Cys Glu Val Asn Ile Asn 
            900                 905                 910         


Gly Ala Thr Leu Lys Ser Glu Cys Cys Ala Thr Leu Gly Ala Ala Trp 
        915                 920                 925             


Gly Ser Pro Cys Glu Arg Cys Glu Leu Asp Thr Ala Cys Pro Arg Gly 
    930                 935                 940                 


Leu Ala Arg Ile Lys Gly Val Thr Cys Glu Asp Val Asn Glu Cys Glu 
945                 950                 955                 960 


Val Phe Pro Gly Val Cys Pro Asn Gly Arg Cys Val Asn Ser Lys Gly 
                965                 970                 975     


Ser Phe His Cys Glu Cys Pro Glu Gly Leu Thr Leu Asp Gly Thr Gly 
            980                 985                 990         


Arg Val Cys Leu Asp Ile Arg Met  Glu Gln Cys Tyr Leu  Lys Trp Asp 
        995                 1000                 1005             


Glu Asp  Glu Cys Ile His Pro  Val Pro Gly Lys Phe  Arg Met Asp 
    1010                 1015                 1020             


Ala Cys  Cys Cys Ala Val Gly  Ala Ala Trp Gly Thr  Glu Cys Glu 
    1025                 1030                 1035             


Glu Cys  Pro Lys Pro Gly Thr  Lys Glu Tyr Glu Thr  Leu Cys Pro 
    1040                 1045                 1050             


Arg Gly  Ala Gly Phe Ala Asn  Arg Gly Asp Val Leu  Thr Gly Arg 
    1055                 1060                 1065             


Pro Phe  Tyr Lys Asp Ile Asn  Glu Cys Lys Ala Phe  Pro Gly Met 
    1070                 1075                 1080             


Cys Thr  Tyr Gly Lys Cys Arg  Asn Thr Ile Gly Ser  Phe Lys Cys 
    1085                 1090                 1095             


Arg Cys  Asn Ser Gly Phe Ala  Leu Asp Met Glu Glu  Arg Asn Cys 
    1100                 1105                 1110             


Thr Asp  Ile Asp Glu Cys Arg  Ile Ser Pro Asp Leu  Cys Gly Ser 
    1115                 1120                 1125             


Gly Ile  Cys Val Asn Thr Pro  Gly Ser Phe Glu Cys  Glu Cys Phe 
    1130                 1135                 1140             


Glu Gly  Tyr Glu Ser Gly Phe  Met Met Met Lys Asn  Cys Met Asp 
    1145                 1150                 1155             


Ile Asp  Glu Cys Glu Arg Asn  Pro Leu Leu Cys Arg  Gly Gly Thr 
    1160                 1165                 1170             


Cys Val  Asn Thr Glu Gly Ser  Phe Gln Cys Asp Cys  Pro Leu Gly 
    1175                 1180                 1185             


His Glu  Leu Ser Pro Ser Arg  Glu Asp Cys Val Asp  Ile Asn Glu 
    1190                 1195                 1200             


Cys Ser  Leu Ser Asp Asn Leu  Cys Arg Asn Gly Lys  Cys Val Asn 
    1205                 1210                 1215             


Met Ile  Gly Thr Tyr Gln Cys  Ser Cys Asn Pro Gly  Tyr Gln Ala 
    1220                 1225                 1230             


Thr Pro  Asp Arg Gln Gly Cys  Thr Asp Ile Asp Glu  Cys Met Ile 
    1235                 1240                 1245             


Met Asn  Gly Gly Cys Asp Thr  Gln Cys Thr Asn Ser  Glu Gly Ser 
    1250                 1255                 1260             


Tyr Glu  Cys Ser Cys Ser Glu  Gly Tyr Ala Leu Met  Pro Asp Gly 
    1265                 1270                 1275             


Arg Ser  Cys Ala Asp Ile Asp  Glu Cys Glu Asn Asn  Pro Asp Ile 
    1280                 1285                 1290             


Cys Asp  Gly Gly Gln Cys Thr  Asn Ile Pro Gly Glu  Tyr Arg Cys 
    1295                 1300                 1305             


Leu Cys  Tyr Asp Gly Phe Met  Ala Ser Met Asp Met  Lys Thr Cys 
    1310                 1315                 1320             


Ile Asp  Val Asn Glu Cys Asp  Leu Asn Ser Asn Ile  Cys Met Phe 
    1325                 1330                 1335             


Gly Glu  Cys Glu Asn Thr Lys  Gly Ser Phe Ile Cys  His Cys Gln 
    1340                 1345                 1350             


Leu Gly  Tyr Ser Val Lys Lys  Gly Thr Thr Gly Cys  Thr Asp Val 
    1355                 1360                 1365             


Asp Glu  Cys Glu Ile Gly Ala  His Asn Cys Asp Met  His Ala Ser 
    1370                 1375                 1380             


Cys Leu  Asn Ile Pro Gly Ser  Phe Lys Cys Ser Cys  Arg Glu Gly 
    1385                 1390                 1395             


Trp Ile  Gly Asn Gly Ile Lys  Cys Ile Asp Leu Asp  Glu Cys Ser 
    1400                 1405                 1410             


Asn Gly  Thr His Gln Cys Ser  Ile Asn Ala Gln Cys  Val Asn Thr 
    1415                 1420                 1425             


Pro Gly  Ser Tyr Arg Cys Ala  Cys Ser Glu Gly Phe  Thr Gly Asp 
    1430                 1435                 1440             


Gly Phe  Thr Cys Ser Asp Val  Asp Glu Cys Ala Glu  Asn Ile Asn 
    1445                 1450                 1455             


Leu Cys  Glu Asn Gly Gln Cys  Leu Asn Val Pro Gly  Ala Tyr Arg 
    1460                 1465                 1470             


Cys Glu  Cys Glu Met Gly Phe  Thr Pro Ala Ser Asp  Ser Arg Ser 
    1475                 1480                 1485             


Cys Gln  Asp Ile Asp Glu Cys  Ser Phe Gln Asn Ile  Cys Val Phe 
    1490                 1495                 1500             


Gly Thr  Cys Asn Asn Leu Pro  Gly Met Phe His Cys  Ile Cys Asp 
    1505                 1510                 1515             


Asp Gly  Tyr Glu Leu Asp Arg  Thr Gly Gly Asn Cys  Thr Asp Ile 
    1520                 1525                 1530             


Asp Glu  Cys Ala Asp Pro Ile  Asn Cys Val Asn Gly  Leu Cys Val 
    1535                 1540                 1545             


Asn Thr  Pro Gly Arg Tyr Glu  Cys Asn Cys Pro Pro  Asp Phe Gln 
    1550                 1555                 1560             


Leu Asn  Pro Thr Gly Val Gly  Cys Val Asp Asn Arg  Val Gly Asn 
    1565                 1570                 1575             


Cys Tyr  Leu Lys Phe Gly Pro  Arg Gly Asp Gly Ser  Leu Ser Cys 
    1580                 1585                 1590             


Asn Thr  Glu Ile Gly Val Gly  Val Ser Arg Ser Ser  Cys Cys Cys 
    1595                 1600                 1605             


Ser Leu  Gly Lys Ala Trp Gly  Asn Pro Cys Glu Thr  Cys Pro Pro 
    1610                 1615                 1620             


Val Asn  Ser Thr Glu Tyr Tyr  Thr Leu Cys Pro Gly  Gly Glu Gly 
    1625                 1630                 1635             


Phe Arg  Pro Asn Pro Ile Thr  Ile Ile Leu Glu Asp  Ile Asp Glu 
    1640                 1645                 1650             


Cys Gln  Glu Leu Pro Gly Leu  Cys Gln Gly Gly Asn  Cys Ile Asn 
    1655                 1660                 1665             


Thr Phe  Gly Ser Phe Gln Cys  Glu Cys Pro Gln Gly  Tyr Tyr Leu 
    1670                 1675                 1680             


Ser Glu  Asp Thr Arg Ile Cys  Glu Asp Ile Asp Glu  Cys Phe Ala 
    1685                 1690                 1695             


His Pro  Gly Val Cys Gly Pro  Gly Thr Cys Tyr Asn  Thr Leu Gly 
    1700                 1705                 1710             


Asn Tyr  Thr Cys Ile Cys Pro  Pro Glu Tyr Met Gln  Val Asn Gly 
    1715                 1720                 1725             


Gly His  Asn Cys Met Asp Met  Arg Lys Ser Phe Cys  Tyr Arg Ser 
    1730                 1735                 1740             


Tyr Asn  Gly Thr Thr Cys Glu  Asn Glu Leu Pro Phe  Asn Val Thr 
    1745                 1750                 1755             


Lys Arg  Met Cys Cys Cys Thr  Tyr Asn Val Gly Lys  Ala Trp Asn 
    1760                 1765                 1770             


Lys Pro  Cys Glu Pro Cys Pro  Thr Pro Gly Thr Ala  Asp Phe Lys 
    1775                 1780                 1785             


Thr Ile  Cys Gly Asn Ile Pro  Gly Phe Thr Phe Asp  Ile His Thr 
    1790                 1795                 1800             


Gly Lys  Ala Val Asp Ile Asp  Glu Cys Lys Glu Ile  Pro Gly Ile 
    1805                 1810                 1815             


Cys Ala  Asn Gly Val Cys Ile  Asn Gln Ile Gly Ser  Phe Arg Cys 
    1820                 1825                 1830             


Glu Cys  Pro Thr Gly Phe Ser  Tyr Asn Asp Leu Leu  Leu Val Cys 
    1835                 1840                 1845             


Glu Asp  Ile Asp Glu Cys Ser  Asn Gly Asp Asn Leu  Cys Gln Arg 
    1850                 1855                 1860             


Asn Ala  Asp Cys Ile Asn Ser  Pro Gly Ser Tyr Arg  Cys Glu Cys 
    1865                 1870                 1875             


Ala Ala  Gly Phe Lys Leu Ser  Pro Asn Gly Ala Cys  Val Asp Arg 
    1880                 1885                 1890             


Asn Glu  Cys Leu Glu Ile Pro  Asn Val Cys Ser His  Gly Leu Cys 
    1895                 1900                 1905             


Val Asp  Leu Gln Gly Ser Tyr  Gln Cys Ile Cys His  Asn Gly Phe 
    1910                 1915                 1920             


Lys Ala  Ser Gln Asp Gln Thr  Met Cys Met Asp Val  Asp Glu Cys 
    1925                 1930                 1935             


Glu Arg  His Pro Cys Gly Asn  Gly Thr Cys Lys Asn  Thr Val Gly 
    1940                 1945                 1950             


Ser Tyr  Asn Cys Leu Cys Tyr  Pro Gly Phe Glu Leu  Thr His Asn 
    1955                 1960                 1965             


Asn Asp  Cys Leu Asp Ile Asp  Glu Cys Ser Ser Phe  Phe Gly Gln 
    1970                 1975                 1980             


Val Cys  Arg Asn Gly Arg Cys  Phe Asn Glu Ile Gly  Ser Phe Lys 
    1985                 1990                 1995             


Cys Leu  Cys Asn Glu Gly Tyr  Glu Leu Thr Pro Asp  Gly Lys Asn 
    2000                 2005                 2010             


Cys Ile  Asp Thr Asn Glu Cys  Val Ala Leu Pro Gly  Ser Cys Ser 
    2015                 2020                 2025             


Pro Gly  Thr Cys Gln Asn Leu  Glu Gly Ser Phe Arg  Cys Ile Cys 
    2030                 2035                 2040             


Pro Pro  Gly Tyr Glu Val Lys  Ser Glu Asn Cys Ile  Asp Ile Asn 
    2045                 2050                 2055             


Glu Cys  Asp Glu Asp Pro Asn  Ile Cys Leu Phe Gly  Ser Cys Thr 
    2060                 2065                 2070             


Asn Thr  Pro Gly Gly Phe Gln  Cys Leu Cys Pro Pro  Gly Phe Val 
    2075                 2080                 2085             


Leu Ser  Asp Asn Gly Arg Arg  Cys Phe Asp Thr Arg  Gln Ser Phe 
    2090                 2095                 2100             


Cys Phe  Thr Asn Phe Glu Asn  Gly Lys Cys Ser Val  Pro Lys Ala 
    2105                 2110                 2115             


Phe Asn  Thr Thr Lys Ala Lys  Cys Cys Cys Ser Lys  Met Pro Gly 
    2120                 2125                 2130             


Glu Gly  Trp Gly Asp Pro Cys  Glu Leu Cys Pro Lys  Asp Asp Glu 
    2135                 2140                 2145             


Val Ala  Phe Gln Asp Leu Cys  Pro Tyr Gly His Gly  Thr Val Pro 
    2150                 2155                 2160             


Ser Leu  His Asp Thr Arg Glu  Asp Val Asn Glu Cys  Leu Glu Ser 
    2165                 2170                 2175             


Pro Gly  Ile Cys Ser Asn Gly  Gln Cys Ile Asn Thr  Asp Gly Ser 
    2180                 2185                 2190             


Phe Arg  Cys Glu Cys Pro Met  Gly Tyr Asn Leu Asp  Tyr Thr Gly 
    2195                 2200                 2205             


Val Arg  Cys Val Asp Thr Asp  Glu Cys Ser Ile Gly  Asn Pro Cys 
    2210                 2215                 2220             


Gly Asn  Gly Thr Cys Thr Asn  Val Ile Gly Ser Phe  Glu Cys Asn 
    2225                 2230                 2235             


Cys Asn  Glu Gly Phe Glu Pro  Gly Pro Met Met Asn  Cys Glu Asp 
    2240                 2245                 2250             


Ile Asn  Glu Cys Ala Gln Asn  Pro Leu Leu Cys Ala  Phe Arg Cys 
    2255                 2260                 2265             


Met Asn  Thr Phe Gly Ser Tyr  Glu Cys Thr Cys Pro  Ile Gly Tyr 
    2270                 2275                 2280             


Ala Leu  Arg Glu Asp Gln Lys  Met Cys Lys Asp Leu  Asp Glu Cys 
    2285                 2290                 2295             


Ala Glu  Gly Leu His Asp Cys  Glu Ser Arg Gly Met  Met Cys Lys 
    2300                 2305                 2310             


Asn Leu  Ile Gly Thr Phe Met  Cys Ile Cys Pro Pro  Gly Met Ala 
    2315                 2320                 2325             


Arg Arg  Pro Asp Gly Glu Gly  Cys Val Asp Glu Asn  Glu Cys Arg 
    2330                 2335                 2340             


Thr Lys  Pro Gly Ile Cys Glu  Asn Gly Arg Cys Val  Asn Ile Ile 
    2345                 2350                 2355             


Gly Ser  Tyr Arg Cys Glu Cys  Asn Glu Gly Phe Gln  Ser Ser Ser 
    2360                 2365                 2370             


Ser Gly  Thr Glu Cys Leu Asp  Asn Arg Gln Gly Leu  Cys Phe Ala 
    2375                 2380                 2385             


Glu Val  Leu Gln Thr Ile Cys  Gln Met Ala Ser Ser  Ser Arg Asn 
    2390                 2395                 2400             


Leu Val  Thr Lys Ser Glu Cys  Cys Cys Asp Gly Gly  Arg Gly Trp 
    2405                 2410                 2415             


Gly His  Gln Cys Glu Leu Cys  Pro Leu Pro Gly Thr  Ala Gln Tyr 
    2420                 2425                 2430             


Lys Lys  Ile Cys Pro His Gly  Pro Gly Tyr Thr Thr  Asp Gly Arg 
    2435                 2440                 2445             


Asp Ile  Asp Glu Cys Lys Val  Met Pro Asn Leu Cys  Thr Asn Gly 
    2450                 2455                 2460             


Gln Cys  Ile Asn Thr Met Gly  Ser Phe Arg Cys Phe  Cys Lys Val 
    2465                 2470                 2475             


Gly Tyr  Thr Thr Asp Ile Ser  Gly Thr Ser Cys Ile  Asp Leu Asp 
    2480                 2485                 2490             


Glu Cys  Ser Gln Ser Pro Lys  Pro Cys Asn Tyr Ile  Cys Lys Asn 
    2495                 2500                 2505             


Thr Glu  Gly Ser Tyr Gln Cys  Ser Cys Pro Arg Gly  Tyr Val Leu 
    2510                 2515                 2520             


Gln Glu  Asp Gly Lys Thr Cys  Lys Asp Leu Asp Glu  Cys Gln Thr 
    2525                 2530                 2535             


Lys Gln  His Asn Cys Gln Phe  Leu Cys Val Asn Thr  Leu Gly Gly 
    2540                 2545                 2550             


Phe Thr  Cys Lys Cys Pro Pro  Gly Phe Thr Gln His  His Thr Ala 
    2555                 2560                 2565             


Cys Ile  Asp Asn Asn Glu Cys  Gly Ser Gln Pro Ser  Leu Cys Gly 
    2570                 2575                 2580             


Ala Lys  Gly Ile Cys Gln Asn  Thr Pro Gly Ser Phe  Ser Cys Glu 
    2585                 2590                 2595             


Cys Gln  Arg Gly Phe Ser Leu  Asp Ala Thr Gly Leu  Asn Cys Glu 
    2600                 2605                 2610             


Asp Val  Asp Glu Cys Asp Gly  Asn His Arg Cys Gln  His Gly Cys 
    2615                 2620                 2625             


Gln Asn  Ile Leu Gly Gly Tyr  Arg Cys Gly Cys Pro  Gln Gly Tyr 
    2630                 2635                 2640             


Ile Gln  His Tyr Gln Trp Asn  Gln Cys Val Asp Glu  Asn Glu Cys 
    2645                 2650                 2655             


Ser Asn  Pro Asn Ala Cys Gly  Ser Ala Ser Cys Tyr  Asn Thr Leu 
    2660                 2665                 2670             


Gly Ser  Tyr Lys Cys Ala Cys  Pro Ser Gly Phe Ser  Phe Asp Gln 
    2675                 2680                 2685             


Phe Ser  Ser Ala Cys His Asp  Val Asn Glu Cys Ser  Ser Ser Lys 
    2690                 2695                 2700             


Asn Pro  Cys Asn Tyr Gly Cys  Ser Asn Thr Glu Gly  Gly Tyr Leu 
    2705                 2710                 2715             


Cys Gly  Cys Pro Pro Gly Tyr  Tyr Arg Val Gly Gln  Gly His Cys 
    2720                 2725                 2730             


Val Ser  Gly Met Gly Phe Asn  Lys Gly Gln Tyr Leu  Ser Leu Asp 
    2735                 2740                 2745             


Thr Glu  Val Asp Glu Glu Asn  Ala Leu Ser Pro Glu  Ala Cys Tyr 
    2750                 2755                 2760             


Glu Cys  Lys Ile Asn Gly Tyr  Ser Lys Lys Asp Ser  Arg Gln Lys 
    2765                 2770                 2775             


Arg Ser  Ile His Glu Pro Asp  Pro Thr Ala Val Glu  Gln Ile Ser 
    2780                 2785                 2790             


Leu Glu  Ser Val Asp Met Asp  Ser Pro Val Asn Met  Lys Phe Asn 
    2795                 2800                 2805             


Leu Ser  His Leu Gly Ser Lys  Glu His Ile Leu Glu  Leu Arg Pro 
    2810                 2815                 2820             


Ala Ile  Gln Pro Leu Asn Asn  His Ile Arg Tyr Val  Ile Ser Gln 
    2825                 2830                 2835             


Gly Asn  Asp Asp Ser Val Phe  Arg Ile His Gln Arg  Asn Gly Leu 
    2840                 2845                 2850             


Ser Tyr  Leu His Thr Ala Lys  Lys Lys Leu Met Pro  Gly Thr Tyr 
    2855                 2860                 2865             


Thr Leu  Glu Ile Thr Ser Ile  Pro Leu Tyr Lys Lys  Lys Glu Leu 
    2870                 2875                 2880             


Lys Lys  Leu Glu Glu Ser Asn  Glu Asp Asp Tyr Leu  Leu Gly Glu 
    2885                 2890                 2895             


Leu Gly  Glu Ala Leu Arg Met  Arg Leu Gln Ile Gln  Leu Tyr 
    2900                 2905                 2910         


<210>  2523
<211>  287
<212>  PRT
<213>  Homo sapiens

<400>  2523

Met Asp Pro Lys Gln Thr Thr Leu Leu Cys Leu Val Leu Cys Leu Gly 
1               5                   10                  15      


Gln Arg Ile Gln Ala Gln Glu Gly Asp Phe Pro Met Pro Phe Ile Ser 
            20                  25                  30          


Ala Lys Ser Ser Pro Val Ile Pro Leu Asp Gly Ser Val Lys Ile Gln 
        35                  40                  45              


Cys Gln Ala Ile Arg Glu Ala Tyr Leu Thr Gln Leu Met Ile Ile Lys 
    50                  55                  60                  


Asn Ser Thr Tyr Arg Glu Ile Gly Arg Arg Leu Lys Phe Trp Asn Glu 
65                  70                  75                  80  


Thr Asp Pro Glu Phe Val Ile Asp His Met Asp Ala Asn Lys Ala Gly 
                85                  90                  95      


Arg Tyr Gln Cys Gln Tyr Arg Ile Gly His Tyr Arg Phe Arg Tyr Ser 
            100                 105                 110         


Asp Thr Leu Glu Leu Val Val Thr Gly Leu Tyr Gly Lys Pro Phe Leu 
        115                 120                 125             


Ser Ala Asp Arg Gly Leu Val Leu Met Pro Gly Glu Asn Ile Ser Leu 
    130                 135                 140                 


Thr Cys Ser Ser Ala His Ile Pro Phe Asp Arg Phe Ser Leu Ala Lys 
145                 150                 155                 160 


Glu Gly Glu Leu Ser Leu Pro Gln His Gln Ser Gly Glu His Pro Ala 
                165                 170                 175     


Asn Phe Ser Leu Gly Pro Val Asp Leu Asn Val Ser Gly Ile Tyr Arg 
            180                 185                 190         


Cys Tyr Gly Trp Tyr Asn Arg Ser Pro Tyr Leu Trp Ser Phe Pro Ser 
        195                 200                 205             


Asn Ala Leu Glu Leu Val Val Thr Asp Ser Ile His Gln Asp Tyr Thr 
    210                 215                 220                 


Thr Gln Asn Leu Ile Arg Met Ala Val Ala Gly Leu Val Leu Val Ala 
225                 230                 235                 240 


Leu Leu Ala Ile Leu Val Glu Asn Trp His Ser His Thr Ala Leu Asn 
                245                 250                 255     


Lys Glu Ala Ser Ala Asp Val Ala Glu Pro Ser Trp Ser Gln Gln Met 
            260                 265                 270         


Cys Gln Pro Gly Leu Thr Phe Ala Arg Thr Pro Ser Val Cys Lys 
        275                 280                 285         


<210>  2524
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  2524

Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Val Pro Gln Lys Pro Lys Val 
            20                  25                  30          


Ser Leu Asn Pro Pro Trp Asn Arg Ile Phe Lys Gly Glu Asn Val Thr 
        35                  40                  45              


Leu Thr Cys Asn Gly Asn Asn Phe Phe Glu Val Ser Ser Thr Lys Trp 
    50                  55                  60                  


Phe His Asn Gly Ser Leu Ser Glu Glu Thr Asn Ser Ser Leu Asn Ile 
65                  70                  75                  80  


Val Asn Ala Lys Phe Glu Asp Ser Gly Glu Tyr Lys Cys Gln His Gln 
                85                  90                  95      


Gln Val Asn Glu Ser Glu Pro Val Tyr Leu Glu Val Phe Ser Asp Trp 
            100                 105                 110         


Leu Leu Leu Gln Ala Ser Ala Glu Val Val Met Glu Gly Gln Pro Leu 
        115                 120                 125             


Phe Leu Arg Cys His Gly Trp Arg Asn Trp Asp Val Tyr Lys Val Ile 
    130                 135                 140                 


Tyr Tyr Lys Asp Gly Glu Ala Leu Lys Tyr Trp Tyr Glu Asn His Asn 
145                 150                 155                 160 


Ile Ser Ile Thr Asn Ala Thr Val Glu Asp Ser Gly Thr Tyr Tyr Cys 
                165                 170                 175     


Thr Gly Lys Val Trp Gln Leu Asp Tyr Glu Ser Glu Pro Leu Asn Ile 
            180                 185                 190         


Thr Val Ile Lys Ala Pro Arg Glu Lys Tyr Trp Leu Gln Phe Phe Ile 
        195                 200                 205             


Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr Gly Leu Phe Ile 
    210                 215                 220                 


Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile Lys Arg Thr Arg 
225                 230                 235                 240 


Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro Asn Pro Lys Asn 
                245                 250                 255     


Asn 
    


<210>  2525
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  2525

Met Glu Glu Gly Gln Tyr Ser Glu Ile Glu Glu Leu Pro Arg Arg Arg 
1               5                   10                  15      


Cys Cys Arg Arg Gly Thr Gln Ile Val Leu Leu Gly Leu Val Thr Ala 
            20                  25                  30          


Ala Leu Trp Ala Gly Leu Leu Thr Leu Leu Leu Leu Trp His Trp Asp 
        35                  40                  45              


Thr Thr Gln Ser Leu Lys Gln Leu Glu Glu Arg Ala Ala Arg Asn Val 
    50                  55                  60                  


Ser Gln Val Ser Lys Asn Leu Glu Ser His His Gly Asp Gln Met Ala 
65                  70                  75                  80  


Gln Lys Ser Gln Ser Thr Gln Ile Ser Gln Glu Leu Glu Glu Leu Arg 
                85                  90                  95      


Ala Glu Gln Gln Arg Leu Lys Ser Gln Asp Leu Glu Leu Ser Trp Asn 
            100                 105                 110         


Leu Asn Gly Leu Gln Ala Asp Leu Ser Ser Phe Lys Ser Gln Glu Leu 
        115                 120                 125             


Asn Glu Arg Asn Glu Ala Ser Asp Leu Leu Glu Arg Leu Arg Glu Glu 
    130                 135                 140                 


Val Thr Lys Leu Arg Met Glu Leu Gln Val Ser Ser Gly Phe Val Cys 
145                 150                 155                 160 


Asn Thr Cys Pro Glu Lys Trp Ile Asn Phe Gln Arg Lys Cys Tyr Tyr 
                165                 170                 175     


Phe Gly Lys Gly Thr Lys Gln Trp Val His Ala Arg Tyr Ala Cys Asp 
            180                 185                 190         


Asp Met Glu Gly Gln Leu Val Ser Ile His Ser Pro Glu Glu Gln Asp 
        195                 200                 205             


Phe Leu Thr Lys His Ala Ser His Thr Gly Ser Trp Ile Gly Leu Arg 
    210                 215                 220                 


Asn Leu Asp Leu Lys Gly Glu Phe Ile Trp Val Asp Gly Ser His Val 
225                 230                 235                 240 


Asp Tyr Ser Asn Trp Ala Pro Gly Glu Pro Thr Ser Arg Ser Gln Gly 
                245                 250                 255     


Glu Asp Cys Val Met Met Arg Gly Ser Gly Arg Trp Asn Asp Ala Phe 
            260                 265                 270         


Cys Asp Arg Lys Leu Gly Ala Trp Val Cys Asp Arg Leu Ala Thr Cys 
        275                 280                 285             


Thr Pro Pro Ala Ser Glu Gly Ser Ala Glu Ser Met Gly Pro Asp Ser 
    290                 295                 300                 


Arg Pro Asp Pro Asp Gly Arg Leu Pro Thr Pro Ser Ala Pro Leu His 
305                 310                 315                 320 


Ser 
    


<210>  2526
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  2526

Met Pro Leu Ser Arg Trp Leu Arg Ser Val Gly Val Phe Leu Leu Pro 
1               5                   10                  15      


Ala Pro Tyr Trp Ala Pro Arg Glu Arg Trp Leu Gly Ser Leu Arg Arg 
            20                  25                  30          


Pro Ser Leu Val His Gly Tyr Pro Val Leu Ala Trp His Ser Ala Arg 
        35                  40                  45              


Cys Trp Cys Gln Ala Trp Thr Glu Glu Pro Arg Ala Leu Cys Ser Ser 
    50                  55                  60                  


Leu Arg Met Asn Gly Asp Gln Asn Ser Asp Val Tyr Ala Gln Glu Lys 
65                  70                  75                  80  


Gln Asp Phe Val Gln His Phe Ser Gln Ile Val Arg Val Leu Thr Glu 
                85                  90                  95      


Asp Glu Met Gly His Pro Glu Ile Gly Asp Ala Ile Ala Arg Leu Lys 
            100                 105                 110         


Glu Val Leu Glu Tyr Asn Ala Ile Gly Gly Lys Tyr Asn Arg Gly Leu 
        115                 120                 125             


Thr Val Val Val Ala Phe Arg Glu Leu Val Glu Pro Arg Lys Gln Asp 
    130                 135                 140                 


Ala Asp Ser Leu Gln Arg Ala Trp Thr Val Gly Trp Cys Val Glu Leu 
145                 150                 155                 160 


Leu Gln Ala Phe Phe Leu Val Ala Asp Asp Ile Met Asp Ser Ser Leu 
                165                 170                 175     


Thr Arg Arg Gly Gln Ile Cys Trp Tyr Gln Lys Pro Gly Val Gly Leu 
            180                 185                 190         


Asp Ala Ile Asn Asp Ala Asn Leu Leu Glu Ala Cys Ile Tyr Arg Leu 
        195                 200                 205             


Leu Lys Leu Tyr Cys Arg Glu Gln Pro Tyr Tyr Leu Asn Leu Ile Glu 
    210                 215                 220                 


Leu Phe Leu Gln Ser Ser Tyr Gln Thr Glu Ile Gly Gln Thr Leu Asp 
225                 230                 235                 240 


Leu Leu Thr Ala Pro Gln Gly Asn Val Asp Leu Val Arg Phe Thr Glu 
                245                 250                 255     


Lys Arg Tyr Lys Ser Ile Val Lys Tyr Lys Thr Ala Phe Tyr Ser Phe 
            260                 265                 270         


Tyr Leu Pro Ile Ala Ala Ala Met Tyr Met Ala Gly Ile Asp Gly Glu 
        275                 280                 285             


Lys Glu His Ala Asn Ala Lys Lys Ile Leu Leu Glu Met Gly Glu Phe 
    290                 295                 300                 


Phe Gln Ile Gln Asp Asp Tyr Leu Asp Leu Phe Gly Asp Pro Ser Val 
305                 310                 315                 320 


Thr Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Leu 
                325                 330                 335     


Val Val Gln Cys Leu Gln Arg Ala Thr Pro Glu Gln Tyr Gln Ile Leu 
            340                 345                 350         


Lys Glu Asn Tyr Gly Gln Lys Glu Ala Glu Lys Val Ala Arg Val Lys 
        355                 360                 365             


Ala Leu Tyr Glu Glu Leu Asp Leu Pro Ala Val Phe Leu Gln Tyr Glu 
    370                 375                 380                 


Glu Asp Ser Tyr Ser His Ile Met Ala Leu Ile Glu Gln Tyr Ala Ala 
385                 390                 395                 400 


Pro Leu Pro Pro Ala Val Phe Leu Gly Leu Ala Arg Lys Ile Tyr Lys 
                405                 410                 415     


Arg Arg Lys 
            


<210>  2527
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  2527

Met Ser Gly Pro Gly Thr Ala Ala Val Ala Leu Leu Pro Ala Val Leu 
1               5                   10                  15      


Leu Ala Leu Leu Ala Pro Trp Ala Gly Arg Gly Gly Ala Ala Ala Pro 
            20                  25                  30          


Thr Ala Pro Asn Gly Thr Leu Glu Ala Glu Leu Glu Arg Arg Trp Glu 
        35                  40                  45              


Ser Leu Val Ala Leu Ser Leu Ala Arg Leu Pro Val Ala Ala Gln Pro 
    50                  55                  60                  


Lys Glu Ala Ala Val Gln Ser Gly Ala Gly Asp Tyr Leu Leu Gly Ile 
65                  70                  75                  80  


Lys Arg Leu Arg Arg Leu Tyr Cys Asn Val Gly Ile Gly Phe His Leu 
                85                  90                  95      


Gln Ala Leu Pro Asp Gly Arg Ile Gly Gly Ala His Ala Asp Thr Arg 
            100                 105                 110         


Asp Ser Leu Leu Glu Leu Ser Pro Val Glu Arg Gly Val Val Ser Ile 
        115                 120                 125             


Phe Gly Val Ala Ser Arg Phe Phe Val Ala Met Ser Ser Lys Gly Lys 
    130                 135                 140                 


Leu Tyr Gly Ser Pro Phe Phe Thr Asp Glu Cys Thr Phe Lys Glu Ile 
145                 150                 155                 160 


Leu Leu Pro Asn Asn Tyr Asn Ala Tyr Glu Ser Tyr Lys Tyr Pro Gly 
                165                 170                 175     


Met Phe Ile Ala Leu Ser Lys Asn Gly Lys Thr Lys Lys Gly Asn Arg 
            180                 185                 190         


Val Ser Pro Thr Met Lys Val Thr His Phe Leu Pro Arg Leu 
        195                 200                 205     


<210>  2528
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  2528

Met His Lys Trp Ile Leu Thr Trp Ile Leu Pro Thr Leu Leu Tyr Arg 
1               5                   10                  15      


Ser Cys Phe His Ile Ile Cys Leu Val Gly Thr Ile Ser Leu Ala Cys 
            20                  25                  30          


Asn Asp Met Thr Pro Glu Gln Met Ala Thr Asn Val Asn Cys Ser Ser 
        35                  40                  45              


Pro Glu Arg His Thr Arg Ser Tyr Asp Tyr Met Glu Gly Gly Asp Ile 
    50                  55                  60                  


Arg Val Arg Arg Leu Phe Cys Arg Thr Gln Trp Tyr Leu Arg Ile Asp 
65                  70                  75                  80  


Lys Arg Gly Lys Val Lys Gly Thr Gln Glu Met Lys Asn Asn Tyr Asn 
                85                  90                  95      


Ile Met Glu Ile Arg Thr Val Ala Val Gly Ile Val Ala Ile Lys Gly 
            100                 105                 110         


Val Glu Ser Glu Phe Tyr Leu Ala Met Asn Lys Glu Gly Lys Leu Tyr 
        115                 120                 125             


Ala Lys Lys Glu Cys Asn Glu Asp Cys Asn Phe Lys Glu Leu Ile Leu 
    130                 135                 140                 


Glu Asn His Tyr Asn Thr Tyr Ala Ser Ala Lys Trp Thr His Asn Gly 
145                 150                 155                 160 


Gly Glu Met Phe Val Ala Leu Asn Gln Lys Gly Ile Pro Val Arg Gly 
                165                 170                 175     


Lys Lys Thr Lys Lys Glu Gln Lys Thr Ala His Phe Leu Pro Met Ala 
            180                 185                 190         


Ile Thr 
        


<210>  2529
<211>  802
<212>  PRT
<213>  Homo sapiens

<400>  2529

Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
1               5                   10                  15      


Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro 
            20                  25                  30          


Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala 
        35                  40                  45              


Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly 
    50                  55                  60                  


His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg 
65                  70                  75                  80  


Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala 
                85                  90                  95      


Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn 
            100                 105                 110         


Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu 
        115                 120                 125             


Asp Pro Lys Ser His Arg Asp Pro Ser Asn Arg His Ser Tyr Pro Gln 
    130                 135                 140                 


Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His 
145                 150                 155                 160 


Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly 
                165                 170                 175     


Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His 
            180                 185                 190         


Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser 
        195                 200                 205             


Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys 
    210                 215                 220                 


Leu Val Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp 
225                 230                 235                 240 


Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro 
                245                 250                 255     


Ala Asn Thr Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys 
            260                 265                 270         


Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val 
        275                 280                 285             


Ile Asn Gly Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val 
    290                 295                 300                 


Leu Lys Thr Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu 
305                 310                 315                 320 


Arg Asn Val Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                325                 330                 335     


Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro 
            340                 345                 350         


Glu Glu Asp Pro Thr Trp Thr Ala Ala Ala Pro Glu Ala Arg Tyr Thr 
        355                 360                 365             


Asp Ile Ile Leu Tyr Ala Ser Gly Ser Leu Ala Leu Ala Val Leu Leu 
    370                 375                 380                 


Leu Leu Ala Gly Leu Tyr Arg Gly Gln Ala Leu His Gly Arg His Pro 
385                 390                 395                 400 


Arg Pro Pro Ala Thr Val Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg 
                405                 410                 415     


Gln Phe Ser Leu Glu Ser Gly Ser Ser Gly Lys Ser Ser Ser Ser Leu 
            420                 425                 430         


Val Arg Gly Val Arg Leu Ser Ser Ser Gly Pro Ala Leu Leu Ala Gly 
        435                 440                 445             


Leu Val Ser Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg 
    450                 455                 460                 


Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln 
465                 470                 475                 480 


Val Val Arg Ala Glu Ala Phe Gly Met Asp Pro Ala Arg Pro Asp Gln 
                485                 490                 495     


Ala Ser Thr Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys 
            500                 505                 510         


Asp Leu Ala Asp Leu Val Ser Glu Met Glu Val Met Lys Leu Ile Gly 
        515                 520                 525             


Arg His Lys Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly 
    530                 535                 540                 


Pro Leu Tyr Val Ile Val Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu 
545                 550                 555                 560 


Phe Leu Arg Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly 
                565                 570                 575     


Pro Arg Ser Ser Glu Gly Pro Leu Ser Phe Pro Val Leu Val Ser Cys 
            580                 585                 590         


Ala Tyr Gln Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys 
        595                 600                 605             


Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn 
    610                 615                 620                 


Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile 
625                 630                 635                 640 


Asp Tyr Tyr Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met 
                645                 650                 655     


Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val 
            660                 665                 670         


Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser 
        675                 680                 685             


Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu 
    690                 695                 700                 


Gly His Arg Met Asp Arg Pro Pro His Cys Pro Pro Glu Leu Tyr Gly 
705                 710                 715                 720 


Leu Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe 
                725                 730                 735     


Lys Gln Leu Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu 
            740                 745                 750         


Glu Tyr Leu Asp Leu Arg Leu Thr Phe Gly Pro Tyr Ser Pro Ser Gly 
        755                 760                 765             


Gly Asp Ala Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His 
    770                 775                 780                 


Asp Pro Leu Pro Leu Gly Ser Ser Ser Phe Pro Phe Gly Ser Gly Val 
785                 790                 795                 800 


Gln Thr 
        


<210>  2530
<211>  1298
<212>  PRT
<213>  Homo sapiens

<400>  2530

Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly 
1               5                   10                  15      


Leu Leu Asp Gly Leu Val Ser Gly Tyr Ser Met Thr Pro Pro Thr Leu 
            20                  25                  30          


Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser 
        35                  40                  45              


Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala 
    50                  55                  60                  


Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val 
65                  70                  75                  80  


Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu 
                85                  90                  95      


Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr 
            100                 105                 110         


Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser 
        115                 120                 125             


Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp 
    130                 135                 140                 


Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val 
145                 150                 155                 160 


Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu 
                165                 170                 175     


Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu 
            180                 185                 190         


Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr 
        195                 200                 205             


Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile 
    210                 215                 220                 


Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu 
225                 230                 235                 240 


Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala 
                245                 250                 255     


Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln 
            260                 265                 270         


Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His 
        275                 280                 285             


Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln His Asp 
    290                 295                 300                 


Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg 
305                 310                 315                 320 


Glu Ser Thr Glu Val Ile Val His Glu Asn Pro Phe Ile Ser Val Glu 
                325                 330                 335     


Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala Gly Asp Glu Leu Val 
            340                 345                 350         


Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp 
        355                 360                 365             


Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His Ser Pro His Ala Leu 
    370                 375                 380                 


Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly Thr Tyr Thr Leu Ala 
385                 390                 395                 400 


Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn Ile Ser Leu Glu Leu 
                405                 410                 415     


Val Val Asn Val Pro Pro Gln Ile His Glu Lys Glu Ala Ser Ser Pro 
            420                 425                 430         


Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu Thr Cys Thr Ala Tyr 
        435                 440                 445             


Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His Trp Arg Pro Trp Thr 
    450                 455                 460                 


Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Gln 
465                 470                 475                 480 


Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala Val Thr Thr Gln Asp 
                485                 490                 495     


Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp Thr Glu Phe Val Glu 
            500                 505                 510         


Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asn Ala Asn Val 
        515                 520                 525             


Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys Val Gly Gln Asp Glu 
    530                 535                 540                 


Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Thr Ile 
545                 550                 555                 560 


Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly Gln Pro Val Leu Leu 
                565                 570                 575     


Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His Leu Arg Trp Tyr Arg 
            580                 585                 590         


Leu Asn Leu Ser Thr Leu His Asp Ala His Gly Asn Pro Leu Leu Leu 
        595                 600                 605             


Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Ala Ala Ser Leu 
    610                 615                 620                 


Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr Leu Ser Leu Ser Ile 
625                 630                 635                 640 


Pro Arg Val Ala Pro Glu His Glu Gly His Tyr Val Cys Glu Val Gln 
                645                 650                 655     


Asp Arg Arg Ser His Asp Lys His Cys His Lys Lys Tyr Leu Ser Val 
            660                 665                 670         


Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu 
        675                 680                 685             


Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys Leu Val Ala Gly Ala 
    690                 695                 700                 


His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Glu 
705                 710                 715                 720 


Lys Ser Gly Val Asp Leu Ala Asp Ser Asn Gln Lys Leu Ser Ile Gln 
                725                 730                 735     


Arg Val Arg Glu Glu Asp Ala Gly Arg Tyr Leu Cys Ser Val Cys Asn 
            740                 745                 750         


Ala Lys Gly Cys Val Asn Ser Ser Ala Ser Val Ala Val Glu Gly Ser 
        755                 760                 765             


Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu Val Gly Thr Gly Val 
    770                 775                 780                 


Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu Ile Phe Cys Asn Met 
785                 790                 795                 800 


Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly Tyr Leu Ser Ile Ile 
                805                 810                 815     


Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln Cys Glu Tyr Leu Ser 
            820                 825                 830         


Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu Arg Leu His Leu Gly 
        835                 840                 845             


Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys Val Val Glu Ala Ser Ala 
    850                 855                 860                 


Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr Val Ala Val Lys Met 
865                 870                 875                 880 


Leu Lys Glu Gly Ala Thr Ala Ser Glu His Arg Ala Leu Met Ser Glu 
                885                 890                 895     


Leu Lys Ile Leu Ile His Ile Gly Asn His Leu Asn Val Val Asn Leu 
            900                 905                 910         


Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro Leu Met Val Ile Val Glu 
        915                 920                 925             


Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu Arg Ala Lys Arg Asp 
    930                 935                 940                 


Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu Gln Arg Gly Arg Phe 
945                 950                 955                 960 


Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg Arg Arg Pro Gly Ser 
                965                 970                 975     


Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys Thr Glu Gly Gly Ala 
            980                 985                 990         


Arg Arg Ala Ser Pro Asp Gln Glu  Ala Glu Asp Leu Trp  Leu Ser Pro 
        995                 1000                 1005             


Leu Thr  Met Glu Asp Leu Val  Cys Tyr Ser Phe Gln  Val Ala Arg 
    1010                 1015                 1020             


Gly Met  Glu Phe Leu Ala Ser  Arg Lys Cys Ile His  Arg Asp Leu 
    1025                 1030                 1035             


Ala Ala  Arg Asn Ile Leu Leu  Ser Glu Ser Asp Val  Val Lys Ile 
    1040                 1045                 1050             


Cys Asp  Phe Gly Leu Ala Arg  Asp Ile Tyr Lys Asp  Pro Asp Tyr 
    1055                 1060                 1065             


Val Arg  Lys Gly Ser Ala Arg  Leu Pro Leu Lys Trp  Met Ala Pro 
    1070                 1075                 1080             


Glu Ser  Ile Phe Asp Lys Val  Tyr Thr Thr Gln Ser  Asp Val Trp 
    1085                 1090                 1095             


Ser Phe  Gly Val Leu Leu Trp  Glu Ile Phe Ser Leu  Gly Ala Ser 
    1100                 1105                 1110             


Pro Tyr  Pro Gly Val Gln Ile  Asn Glu Glu Phe Cys  Gln Arg Leu 
    1115                 1120                 1125             


Arg Asp  Gly Thr Arg Met Arg  Ala Pro Glu Leu Ala  Thr Pro Ala 
    1130                 1135                 1140             


Ile Arg  Arg Ile Met Leu Asn  Cys Trp Ser Gly Asp  Pro Lys Ala 
    1145                 1150                 1155             


Arg Pro  Ala Phe Ser Glu Leu  Val Glu Ile Leu Gly  Asp Leu Leu 
    1160                 1165                 1170             


Gln Gly  Arg Gly Leu Gln Glu  Glu Glu Glu Val Cys  Met Ala Pro 
    1175                 1180                 1185             


Arg Ser  Ser Gln Ser Ser Glu  Glu Gly Ser Phe Ser  Gln Val Ser 
    1190                 1195                 1200             


Thr Met  Ala Leu His Ile Ala  Gln Ala Asp Ala Glu  Asp Ser Pro 
    1205                 1210                 1215             


Pro Ser  Leu Gln Arg His Ser  Leu Ala Ala Arg Tyr  Tyr Asn Trp 
    1220                 1225                 1230             


Val Ser  Phe Pro Gly Cys Leu  Ala Arg Gly Ala Glu  Thr Arg Gly 
    1235                 1240                 1245             


Ser Ser  Arg Met Lys Thr Phe  Glu Glu Phe Pro Met  Thr Pro Thr 
    1250                 1255                 1260             


Thr Tyr  Lys Gly Ser Val Asp  Asn Gln Thr Asp Ser  Gly Met Val 
    1265                 1270                 1275             


Leu Ala  Ser Glu Glu Phe Glu  Gln Ile Glu Ser Arg  His Arg Gln 
    1280                 1285                 1290             


Glu Ser  Gly Phe Arg 
    1295             


<210>  2531
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  2531

Met Ala Lys Lys Val Ala Val Ile Gly Ala Gly Val Ser Gly Leu Ser 
1               5                   10                  15      


Ser Ile Lys Cys Cys Val Asp Glu Asp Leu Glu Pro Thr Cys Phe Glu 
            20                  25                  30          


Arg Ser Asp Asp Ile Gly Gly Leu Trp Lys Phe Thr Glu Ser Ser Lys 
        35                  40                  45              


Asp Gly Met Thr Arg Val Tyr Lys Ser Leu Val Thr Asn Val Cys Lys 
    50                  55                  60                  


Glu Met Ser Cys Tyr Ser Asp Phe Pro Phe His Glu Asp Tyr Pro Asn 
65                  70                  75                  80  


Phe Met Asn His Glu Lys Phe Trp Asp Tyr Leu Gln Glu Phe Ala Glu 
                85                  90                  95      


His Phe Asp Leu Leu Lys Tyr Ile Gln Phe Lys Thr Thr Val Cys Ser 
            100                 105                 110         


Ile Thr Lys Arg Pro Asp Phe Ser Glu Thr Gly Gln Trp Asp Val Val 
        115                 120                 125             


Thr Glu Thr Glu Gly Lys Gln Asn Arg Ala Val Phe Asp Ala Val Met 
    130                 135                 140                 


Val Cys Thr Gly His Phe Leu Asn Pro His Leu Pro Leu Glu Ala Phe 
145                 150                 155                 160 


Pro Gly Ile His Lys Phe Lys Gly Gln Ile Leu His Ser Gln Glu Tyr 
                165                 170                 175     


Lys Ile Pro Glu Gly Phe Gln Gly Lys Arg Val Leu Val Ile Gly Leu 
            180                 185                 190         


Gly Asn Thr Gly Gly Asp Ile Ala Val Glu Leu Ser Arg Thr Ala Ala 
        195                 200                 205             


Gln Val Leu Leu Ser Thr Arg Thr Gly Thr Trp Val Leu Gly Arg Ser 
    210                 215                 220                 


Ser Asp Trp Gly Tyr Pro Tyr Asn Met Met Val Thr Arg Arg Cys Cys 
225                 230                 235                 240 


Ser Phe Ile Ala Gln Val Leu Pro Ser Arg Phe Leu Asn Trp Ile Gln 
                245                 250                 255     


Glu Arg Lys Leu Asn Lys Arg Phe Asn His Glu Asp Tyr Gly Leu Ser 
            260                 265                 270         


Ile Thr Lys Gly Lys Lys Ala Lys Phe Ile Val Asn Asp Glu Leu Pro 
        275                 280                 285             


Asn Cys Ile Leu Cys Gly Ala Ile Thr Met Lys Thr Ser Val Ile Glu 
    290                 295                 300                 


Phe Thr Glu Thr Ser Ala Val Phe Glu Asp Gly Thr Val Glu Glu Asn 
305                 310                 315                 320 


Ile Asp Val Val Ile Phe Thr Thr Gly Tyr Thr Phe Ser Phe Pro Phe 
                325                 330                 335     


Phe Glu Glu Pro Leu Lys Ser Leu Cys Thr Lys Lys Ile Phe Leu Tyr 
            340                 345                 350         


Lys Gln Val Phe Pro Leu Asn Leu Glu Arg Ala Thr Leu Ala Ile Ile 
        355                 360                 365             


Gly Leu Ile Gly Leu Lys Gly Ser Ile Leu Ser Gly Thr Glu Leu Gln 
    370                 375                 380                 


Ala Arg Trp Val Thr Arg Val Phe Lys Gly Leu Cys Lys Ile Pro Pro 
385                 390                 395                 400 


Ser Gln Lys Leu Met Met Glu Ala Thr Glu Lys Glu Gln Leu Ile Lys 
                405                 410                 415     


Arg Gly Val Phe Lys Asp Thr Ser Lys Asp Lys Phe Asp Tyr Ile Ala 
            420                 425                 430         


Tyr Met Asp Asp Ile Ala Ala Cys Ile Gly Thr Lys Pro Ser Ile Pro 
        435                 440                 445             


Leu Leu Phe Leu Lys Asp Pro Arg Leu Ala Trp Glu Val Phe Phe Gly 
    450                 455                 460                 


Pro Cys Thr Pro Tyr Gln Tyr Arg Leu Met Gly Pro Gly Lys Trp Asp 
465                 470                 475                 480 


Gly Ala Arg Asn Ala Ile Leu Thr Gln Trp Asp Arg Thr Leu Lys Pro 
                485                 490                 495     


Leu Lys Thr Arg Ile Val Pro Asp Ser Ser Lys Pro Ala Ser Met Ser 
            500                 505                 510         


His Tyr Leu Lys Ala Trp Gly Ala Pro Val Leu Leu Ala Ser Leu Leu 
        515                 520                 525             


Leu Ile Cys Lys Ser Ser Leu Phe Leu Lys Leu Val Arg Asp Lys Leu 
    530                 535                 540                 


Gln Asp Arg Met Ser Pro Tyr Leu Val Ser Leu Trp Arg Gly 
545                 550                 555             


<210>  2532
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  2532

Met Glu Thr Asn Ser Ser Leu Pro Thr Asn Ile Ser Gly Gly Thr Pro 
1               5                   10                  15      


Ala Val Ser Ala Gly Tyr Leu Phe Leu Asp Ile Ile Thr Tyr Leu Val 
            20                  25                  30          


Phe Ala Val Thr Phe Val Leu Gly Val Leu Gly Asn Gly Leu Val Ile 
        35                  40                  45              


Trp Val Ala Gly Phe Arg Met Thr His Thr Val Thr Thr Ile Ser Tyr 
    50                  55                  60                  


Leu Asn Leu Ala Val Ala Asp Phe Cys Phe Thr Ser Thr Leu Pro Phe 
65                  70                  75                  80  


Phe Met Val Arg Lys Ala Met Gly Gly His Trp Pro Phe Gly Trp Phe 
                85                  90                  95      


Leu Cys Lys Phe Val Phe Thr Ile Val Asp Ile Asn Leu Phe Gly Ser 
            100                 105                 110         


Val Phe Leu Ile Ala Leu Ile Ala Leu Asp Arg Cys Val Cys Val Leu 
        115                 120                 125             


His Pro Val Trp Thr Gln Asn His Arg Thr Val Ser Leu Ala Lys Lys 
    130                 135                 140                 


Val Ile Ile Gly Pro Trp Val Met Ala Leu Leu Leu Thr Leu Pro Val 
145                 150                 155                 160 


Ile Ile Arg Val Thr Thr Val Pro Gly Lys Thr Gly Thr Val Ala Cys 
                165                 170                 175     


Thr Phe Asn Phe Ser Pro Trp Thr Asn Asp Pro Lys Glu Arg Ile Asn 
            180                 185                 190         


Val Ala Val Ala Met Leu Thr Val Arg Gly Ile Ile Arg Phe Ile Ile 
        195                 200                 205             


Gly Phe Ser Ala Pro Met Ser Ile Val Ala Val Ser Tyr Gly Leu Ile 
    210                 215                 220                 


Ala Thr Lys Ile His Lys Gln Gly Leu Ile Lys Ser Ser Arg Pro Leu 
225                 230                 235                 240 


Arg Val Leu Ser Phe Val Ala Ala Ala Phe Phe Leu Cys Trp Ser Pro 
                245                 250                 255     


Tyr Gln Val Val Ala Leu Ile Ala Thr Val Arg Ile Arg Glu Leu Leu 
            260                 265                 270         


Gln Gly Met Tyr Lys Glu Ile Gly Ile Ala Val Asp Val Thr Ser Ala 
        275                 280                 285             


Leu Ala Phe Phe Asn Ser Cys Leu Asn Pro Met Leu Tyr Val Phe Met 
    290                 295                 300                 


Gly Gln Asp Phe Arg Glu Arg Leu Ile His Ala Leu Pro Ala Ser Leu 
305                 310                 315                 320 


Glu Arg Ala Leu Thr Glu Asp Ser Thr Gln Thr Ser Asp Thr Ala Thr 
                325                 330                 335     


Asn Ser Thr Leu Pro Ser Ala Glu Val Glu Leu Gln Ala Lys 
            340                 345                 350 


<210>  2533
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  2533

Met Glu Thr Asn Phe Ser Ile Pro Leu Asn Glu Thr Glu Glu Val Leu 
1               5                   10                  15      


Pro Glu Pro Ala Gly His Thr Val Leu Trp Ile Phe Ser Leu Leu Val 
            20                  25                  30          


His Gly Val Thr Phe Val Phe Gly Val Leu Gly Asn Gly Leu Val Ile 
        35                  40                  45              


Trp Val Ala Gly Phe Arg Met Thr Arg Thr Val Asn Thr Ile Cys Tyr 
    50                  55                  60                  


Leu Asn Leu Ala Leu Ala Asp Phe Ser Phe Ser Ala Ile Leu Pro Phe 
65                  70                  75                  80  


Arg Met Val Ser Val Ala Met Arg Glu Lys Trp Pro Phe Gly Ser Phe 
                85                  90                  95      


Leu Cys Lys Leu Val His Val Met Ile Asp Ile Asn Leu Phe Val Ser 
            100                 105                 110         


Val Tyr Leu Ile Thr Ile Ile Ala Leu Asp Arg Cys Ile Cys Val Leu 
        115                 120                 125             


His Pro Ala Trp Ala Gln Asn His Arg Thr Met Ser Leu Ala Lys Arg 
    130                 135                 140                 


Val Met Thr Gly Leu Trp Ile Phe Thr Ile Val Leu Thr Leu Pro Asn 
145                 150                 155                 160 


Phe Ile Phe Trp Thr Thr Ile Ser Thr Thr Asn Gly Asp Thr Tyr Cys 
                165                 170                 175     


Ile Phe Asn Phe Ala Phe Trp Gly Asp Thr Ala Val Glu Arg Leu Asn 
            180                 185                 190         


Val Phe Ile Thr Met Ala Lys Val Phe Leu Ile Leu His Phe Ile Ile 
        195                 200                 205             


Gly Phe Ser Val Pro Met Ser Ile Ile Thr Val Cys Tyr Gly Ile Ile 
    210                 215                 220                 


Ala Ala Lys Ile His Arg Asn His Met Ile Lys Ser Ser Arg Pro Leu 
225                 230                 235                 240 


Arg Val Phe Ala Ala Val Val Ala Ser Phe Phe Ile Cys Trp Phe Pro 
                245                 250                 255     


Tyr Glu Leu Ile Gly Ile Leu Met Ala Val Trp Leu Lys Glu Met Leu 
            260                 265                 270         


Leu Asn Gly Lys Tyr Lys Ile Ile Leu Val Leu Ile Asn Pro Thr Ser 
        275                 280                 285             


Ser Leu Ala Phe Phe Asn Ser Cys Leu Asn Pro Ile Leu Tyr Val Phe 
    290                 295                 300                 


Met Gly Arg Asn Phe Gln Glu Arg Leu Ile Arg Ser Leu Pro Thr Ser 
305                 310                 315                 320 


Leu Glu Arg Ala Leu Thr Glu Val Pro Asp Ser Ala Gln Thr Ser Asn 
                325                 330                 335     


Thr Asp Thr Thr Ser Ala Ser Pro Pro Glu Glu Thr Glu Leu Gln Ala 
            340                 345                 350         


Met 
    


<210>  2534
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  2534

Met Arg Arg Leu Trp Gly Ala Ala Arg Lys Pro Ser Gly Ala Gly Trp 
1               5                   10                  15      


Glu Lys Glu Trp Ala Glu Ala Pro Gln Glu Ala Pro Gly Ala Trp Ser 
            20                  25                  30          


Gly Arg Leu Gly Pro Gly Arg Ser Gly Arg Lys Gly Arg Ala Val Pro 
        35                  40                  45              


Gly Trp Ala Ser Trp Pro Ala His Leu Ala Leu Ala Ala Arg Pro Ala 
    50                  55                  60                  


Arg His Leu Gly Gly Ala Gly Gln Gly Pro Arg Pro Leu His Ser Gly 
65                  70                  75                  80  


Thr Ala Pro Phe His Ser Arg Ala Ser Gly Glu Arg Gln Arg Arg Leu 
                85                  90                  95      


Glu Pro Gln Leu Gln His Glu Ser Arg Cys Arg Ser Ser Thr Pro Ala 
            100                 105                 110         


Asp Ala Trp Arg Ala Glu Ala Ala Leu Pro Val Arg Ala Met Gly Ala 
        115                 120                 125             


Pro Trp Gly Ser Pro Thr Ala Ala Ala Gly Gly Arg Arg Gly Trp Arg 
    130                 135                 140                 


Arg Gly Arg Gly Leu Pro Trp Thr Val Cys Val Leu Ala Ala Ala Gly 
145                 150                 155                 160 


Leu Thr Cys Thr Ala Leu Ile Thr Tyr Ala Cys Trp Gly Gln Leu Pro 
                165                 170                 175     


Pro Leu Pro Trp Ala Ser Pro Thr Pro Ser Arg Pro Val Gly Val Leu 
            180                 185                 190         


Leu Trp Trp Glu Pro Phe Gly Gly Arg Asp Ser Ala Pro Arg Pro Pro 
        195                 200                 205             


Pro Asp Cys Arg Leu Arg Phe Asn Ile Ser Gly Cys Arg Leu Leu Thr 
    210                 215                 220                 


Asp Arg Ala Ser Tyr Gly Glu Ala Gln Ala Val Leu Phe His His Arg 
225                 230                 235                 240 


Asp Leu Val Lys Gly Pro Pro Asp Trp Pro Pro Pro Trp Gly Ile Gln 
                245                 250                 255     


Ala His Thr Ala Glu Glu Val Asp Leu Arg Val Leu Asp Tyr Glu Glu 
            260                 265                 270         


Ala Ala Ala Ala Ala Glu Ala Leu Ala Thr Ser Ser Pro Arg Pro Pro 
        275                 280                 285             


Gly Gln Arg Trp Val Trp Met Asn Phe Glu Ser Pro Ser His Ser Pro 
    290                 295                 300                 


Gly Leu Arg Ser Leu Ala Ser Asn Leu Phe Asn Trp Thr Leu Ser Tyr 
305                 310                 315                 320 


Arg Ala Asp Ser Asp Val Phe Val Pro Tyr Gly Tyr Leu Tyr Pro Arg 
                325                 330                 335     


Ser His Pro Gly Asp Pro Pro Ser Gly Leu Ala Pro Pro Leu Ser Arg 
            340                 345                 350         


Lys Gln Gly Leu Val Ala Trp Val Val Ser His Trp Asp Glu Arg Gln 
        355                 360                 365             


Ala Arg Val Arg Tyr Tyr His Gln Leu Ser Gln His Val Thr Val Asp 
    370                 375                 380                 


Val Phe Gly Arg Gly Gly Pro Gly Gln Pro Val Pro Glu Ile Gly Leu 
385                 390                 395                 400 


Leu His Thr Val Ala Arg Tyr Lys Phe Tyr Leu Ala Phe Glu Asn Ser 
                405                 410                 415     


Gln His Leu Asp Tyr Ile Thr Glu Lys Leu Trp Arg Asn Ala Leu Leu 
            420                 425                 430         


Ala Gly Ala Val Pro Val Val Leu Gly Pro Asp Arg Ala Asn Tyr Glu 
        435                 440                 445             


Arg Phe Val Pro Arg Gly Ala Phe Ile His Val Asp Asp Phe Pro Ser 
    450                 455                 460                 


Ala Ser Ser Leu Ala Ser Tyr Leu Leu Phe Leu Asp Arg Asn Pro Ala 
465                 470                 475                 480 


Val Tyr Arg Arg Tyr Phe His Trp Arg Arg Ser Tyr Ala Val His Ile 
                485                 490                 495     


Thr Ser Phe Trp Asp Glu Pro Trp Cys Arg Val Cys Gln Ala Val Gln 
            500                 505                 510         


Arg Ala Gly Asp Arg Pro Lys Ser Ile Arg Asn Leu Ala Ser Trp Phe 
        515                 520                 525             


Glu Arg 
    530 


<210>  2535
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  2535

Met Asp Pro Leu Gly Pro Ala Lys Pro Gln Trp Leu Trp Arg Arg Cys 
1               5                   10                  15      


Leu Ala Gly Leu Leu Phe Gln Leu Leu Val Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Arg Asp Asp Ala Thr Gly Ser Pro Arg Pro Gly 
        35                  40                  45              


Leu Met Ala Val Glu Pro Val Thr Gly Ala Pro Asn Gly Ser Arg Cys 
    50                  55                  60                  


Gln Asp Ser Met Ala Thr Pro Ala His Pro Thr Leu Leu Ile Leu Leu 
65                  70                  75                  80  


Trp Thr Trp Pro Phe Asn Thr Pro Val Ala Leu Pro Arg Cys Ser Glu 
                85                  90                  95      


Met Val Pro Gly Ala Ala Asp Cys Asn Ile Thr Ala Asp Ser Ser Val 
            100                 105                 110         


Tyr Pro Gln Ala Asp Ala Val Ile Val His His Trp Asp Ile Met Tyr 
        115                 120                 125             


Asn Pro Ser Ala Asn Leu Pro Pro Pro Thr Arg Pro Gln Gly Gln Arg 
    130                 135                 140                 


Trp Ile Trp Phe Ser Met Glu Ser Pro Ser Asn Cys Arg His Leu Glu 
145                 150                 155                 160 


Ala Leu Asp Gly Tyr Phe Asn Leu Thr Met Ser Tyr Arg Ser Asp Ser 
                165                 170                 175     


Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser Gly Gln Pro 
            180                 185                 190         


Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu Val Ala Trp 
        195                 200                 205             


Ala Val Ser Asn Trp Lys Pro Asp Ser Ala Arg Val Arg Tyr Tyr Gln 
    210                 215                 220                 


Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg Ser His Lys 
225                 230                 235                 240 


Pro Leu Pro Lys Gly Thr Met Met Glu Thr Leu Ser Arg Tyr Lys Phe 
                245                 250                 255     


Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile Thr Glu Lys 
            260                 265                 270         


Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val Val Leu Gly 
        275                 280                 285             


Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp Ala Phe Ile 
    290                 295                 300                 


His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg Tyr Leu Gln 
305                 310                 315                 320 


Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe His Trp Arg 
                325                 330                 335     


Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Ala Phe Cys Lys 
            340                 345                 350         


Ala Cys Trp Lys Leu Gln Gln Glu Ser Arg Tyr Gln Thr Val Arg Ser 
        355                 360                 365             


Ile Ala Ala Trp Phe Thr 
    370                 


<210>  2536
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  2536

Met Leu Leu Leu Ala Ala Ala Phe Leu Val Ala Phe Val Leu Leu Leu 
1               5                   10                  15      


Tyr Met Val Ser Pro Leu Ile Ser Pro Lys Pro Leu Ala Leu Pro Gly 
            20                  25                  30          


Ala His Val Val Val Thr Gly Gly Ser Ser Gly Ile Gly Lys Cys Ile 
        35                  40                  45              


Ala Ile Glu Cys Tyr Lys Gln Gly Ala Phe Ile Thr Leu Val Ala Arg 
    50                  55                  60                  


Asn Glu Asp Lys Leu Leu Gln Ala Lys Lys Glu Ile Glu Met His Ser 
65                  70                  75                  80  


Ile Asn Asp Lys Gln Val Val Leu Cys Ile Ser Val Asp Val Ser Gln 
                85                  90                  95      


Asp Tyr Asn Gln Val Glu Asn Val Ile Lys Gln Ala Gln Glu Lys Leu 
            100                 105                 110         


Gly Pro Val Asp Met Leu Val Asn Cys Ala Gly Met Ala Val Ser Gly 
        115                 120                 125             


Lys Phe Glu Asp Leu Glu Val Ser Thr Phe Glu Arg Leu Met Ser Ile 
    130                 135                 140                 


Asn Tyr Leu Gly Ser Val Tyr Pro Ser Arg Ala Val Ile Thr Thr Met 
145                 150                 155                 160 


Lys Glu Arg Arg Val Gly Arg Ile Val Phe Val Ser Ser Gln Ala Gly 
                165                 170                 175     


Gln Leu Gly Leu Phe Gly Phe Thr Ala Tyr Ser Ala Ser Lys Phe Ala 
            180                 185                 190         


Ile Arg Gly Leu Ala Glu Ala Leu Gln Met Glu Val Lys Pro Tyr Asn 
        195                 200                 205             


Val Tyr Ile Thr Val Ala Tyr Pro Pro Asp Thr Asp Thr Pro Gly Phe 
    210                 215                 220                 


Ala Glu Glu Asn Arg Thr Lys Pro Leu Glu Thr Arg Leu Ile Ser Glu 
225                 230                 235                 240 


Thr Thr Ser Val Cys Lys Pro Glu Gln Val Ala Lys Gln Ile Val Lys 
                245                 250                 255     


Asp Ala Ile Gln Gly Asn Phe Asn Ser Ser Leu Gly Ser Asp Gly Tyr 
            260                 265                 270         


Met Leu Ser Ala Leu Thr Cys Gly Met Ala Pro Val Thr Ser Ile Thr 
        275                 280                 285             


Glu Gly Leu Gln Gln Val Val Thr Met Gly Leu Phe Arg Thr Ile Ala 
    290                 295                 300                 


Leu Phe Tyr Leu Gly Ser Phe Asp Ser Ile Val Arg Arg Cys Met Met 
305                 310                 315                 320 


Gln Arg Glu Lys Ser Glu Asn Ala Asp Lys Thr Ala 
                325                 330         


<210>  2537
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  2537

Met Gly Asn Cys Leu His Arg Ala Glu Leu Ser Pro Ser Thr Glu Asn 
1               5                   10                  15      


Ser Ser Gln Leu Asp Phe Glu Asp Val Trp Asn Ser Ser Tyr Gly Val 
            20                  25                  30          


Asn Asp Ser Phe Pro Asp Gly Asp Tyr Gly Ala Asn Leu Glu Ala Ala 
        35                  40                  45              


Ala Pro Cys His Ser Cys Asn Leu Leu Asp Asp Ser Ala Leu Pro Phe 
    50                  55                  60                  


Phe Ile Leu Thr Ser Val Leu Gly Ile Leu Ala Ser Ser Thr Val Leu 
65                  70                  75                  80  


Phe Met Leu Phe Arg Pro Leu Phe Arg Trp Gln Leu Cys Pro Gly Trp 
                85                  90                  95      


Pro Val Leu Ala Gln Leu Ala Val Gly Ser Ala Leu Phe Ser Ile Val 
            100                 105                 110         


Val Pro Val Leu Ala Pro Gly Leu Gly Ser Thr Arg Ser Ser Ala Leu 
        115                 120                 125             


Cys Ser Leu Gly Tyr Cys Val Trp Tyr Gly Ser Ala Phe Ala Gln Ala 
    130                 135                 140                 


Leu Leu Leu Gly Cys His Ala Ser Leu Gly His Arg Leu Gly Ala Gly 
145                 150                 155                 160 


Gln Val Pro Gly Leu Thr Leu Gly Leu Thr Val Gly Ile Trp Gly Val 
                165                 170                 175     


Ala Ala Leu Leu Thr Leu Pro Val Thr Leu Ala Ser Gly Ala Ser Gly 
            180                 185                 190         


Gly Leu Cys Thr Leu Ile Tyr Ser Thr Glu Leu Lys Ala Leu Gln Ala 
        195                 200                 205             


Thr His Thr Val Ala Cys Leu Ala Ile Phe Val Leu Leu Pro Leu Gly 
    210                 215                 220                 


Leu Phe Gly Ala Lys Gly Leu Lys Lys Ala Leu Gly Met Gly Pro Gly 
225                 230                 235                 240 


Pro Trp Met Asn Ile Leu Trp Ala Trp Phe Ile Phe Trp Trp Pro His 
                245                 250                 255     


Gly Val Val Leu Gly Leu Asp Phe Leu Val Arg Ser Lys Leu Leu Leu 
            260                 265                 270         


Leu Ser Thr Cys Leu Ala Gln Gln Ala Leu Asp Leu Leu Leu Asn Leu 
        275                 280                 285             


Ala Glu Ala Leu Ala Ile Leu His Cys Val Ala Thr Pro Leu Leu Leu 
    290                 295                 300                 


Ala Leu Phe Cys His Gln Ala Thr Arg Thr Leu Leu Pro Ser Leu Pro 
305                 310                 315                 320 


Leu Pro Glu Gly Trp Ser Ser His Leu Asp Thr Leu Gly Ser Lys Ser 
                325                 330                 335     


<210>  2538
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  2538

Met Arg Gln Lys Ala Val Ser Leu Phe Leu Cys Tyr Leu Leu Leu Phe 
1               5                   10                  15      


Thr Cys Ser Gly Val Glu Ala Gly Lys Lys Lys Cys Ser Glu Ser Ser 
            20                  25                  30          


Asp Ser Gly Ser Gly Phe Trp Lys Ala Leu Thr Phe Met Ala Val Gly 
        35                  40                  45              


Gly Gly Leu Ala Val Ala Gly Leu Pro Ala Leu Gly Phe Thr Gly Ala 
    50                  55                  60                  


Gly Ile Ala Ala Asn Ser Val Ala Ala Ser Leu Met Ser Trp Ser Ala 
65                  70                  75                  80  


Ile Leu Asn Gly Gly Gly Val Pro Ala Gly Gly Leu Val Ala Thr Leu 
                85                  90                  95      


Gln Ser Leu Gly Ala Gly Gly Ser Ser Val Val Ile Gly Asn Ile Gly 
            100                 105                 110         


Ala Leu Met Gly Tyr Ala Thr His Lys Tyr Leu Asp Ser Glu Glu Asp 
        115                 120                 125             


Glu Glu 
    130 


<210>  2539
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  2539

Met Leu Ala Val Pro Asn Met Arg Phe Gly Ile Phe Leu Leu Trp Trp 
1               5                   10                  15      


Gly Trp Val Leu Ala Thr Glu Ser Arg Met His Trp Pro Gly Arg Glu 
            20                  25                  30          


Val His Glu Met Ser Lys Lys Gly Arg Pro Gln Arg Gln Arg Arg Glu 
        35                  40                  45              


Val His Glu Asp Ala His Lys Gln Val Ser Pro Ile Leu Arg Arg Ser 
    50                  55                  60                  


Pro Asp Ile Thr Lys Ser Pro Leu Thr Lys Ser Glu Gln Leu Leu Arg 
65                  70                  75                  80  


Ile Asp Asp His Asp Phe Ser Met Arg Pro Gly Phe Gly Gly Pro Ala 
                85                  90                  95      


Ile Pro Val Gly Val Asp Val Gln Val Glu Ser Leu Asp Ser Ile Ser 
            100                 105                 110         


Glu Val Asp Met Asp Phe Thr Met Thr Leu Tyr Leu Arg His Tyr Trp 
        115                 120                 125             


Lys Asp Glu Arg Leu Ser Phe Pro Ser Thr Asn Asn Leu Ser Met Thr 
    130                 135                 140                 


Phe Asp Gly Arg Leu Val Lys Lys Ile Trp Val Pro Asp Met Phe Phe 
145                 150                 155                 160 


Val His Ser Lys Arg Ser Phe Ile His Asp Thr Thr Thr Asp Asn Val 
                165                 170                 175     


Met Leu Arg Val Gln Pro Asp Gly Lys Val Leu Tyr Ser Leu Arg Val 
            180                 185                 190         


Thr Val Thr Ala Met Cys Asn Met Asp Phe Ser Arg Phe Pro Leu Asp 
        195                 200                 205             


Thr Gln Thr Cys Ser Leu Glu Ile Glu Ser Tyr Ala Tyr Thr Glu Asp 
    210                 215                 220                 


Asp Leu Met Leu Tyr Trp Lys Lys Gly Asn Asp Ser Leu Lys Thr Asp 
225                 230                 235                 240 


Glu Arg Ile Ser Leu Ser Gln Phe Leu Ile Gln Glu Phe His Thr Thr 
                245                 250                 255     


Thr Lys Leu Ala Phe Tyr Ser Ser Thr Gly Trp Tyr Asn Arg Leu Tyr 
            260                 265                 270         


Ile Asn Phe Thr Leu Arg Arg His Ile Phe Phe Phe Leu Leu Gln Thr 
        275                 280                 285             


Tyr Phe Pro Ala Thr Leu Met Val Met Leu Ser Trp Val Ser Phe Trp 
    290                 295                 300                 


Ile Asp Arg Arg Ala Val Pro Ala Arg Val Pro Leu Gly Ile Thr Thr 
305                 310                 315                 320 


Val Leu Thr Met Ser Thr Ile Ile Thr Gly Val Asn Ala Ser Met Pro 
                325                 330                 335     


Arg Val Ser Tyr Ile Lys Ala Val Asp Ile Tyr Leu Trp Val Ser Phe 
            340                 345                 350         


Val Phe Val Phe Leu Ser Val Leu Glu Tyr Ala Ala Val Asn Tyr Leu 
        355                 360                 365             


Thr Thr Val Gln Glu Arg Lys Glu Gln Lys Leu Arg Glu Lys Leu Pro 
    370                 375                 380                 


Cys Thr Ser Gly Leu Pro Pro Pro Arg Thr Ala Met Leu Asp Gly Asn 
385                 390                 395                 400 


Tyr Ser Asp Gly Glu Val Asn Asp Leu Asp Asn Tyr Met Pro Glu Asn 
                405                 410                 415     


Gly Glu Lys Pro Asp Arg Met Met Val Gln Leu Thr Leu Ala Ser Glu 
            420                 425                 430         


Arg Ser Ser Pro Gln Arg Lys Ser Gln Arg Ser Ser Tyr Val Ser Met 
        435                 440                 445             


Arg Ile Asp Thr His Ala Ile Asp Lys Tyr Ser Arg Ile Ile Phe Pro 
    450                 455                 460                 


Ala Ala Tyr Ile Leu Phe Asn Leu Ile Tyr Trp Ser Ile Phe Ser 
465                 470                 475                 


<210>  2540
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  2540

Met Pro Tyr Phe Thr Arg Leu Ile Leu Phe Leu Phe Cys Leu Met Val 
1               5                   10                  15      


Leu Val Glu Ser Arg Lys Pro Lys Arg Lys Arg Trp Thr Gly Gln Val 
            20                  25                  30          


Glu Met Pro Lys Pro Ser His Leu Tyr Lys Lys Asn Leu Asp Val Thr 
        35                  40                  45              


Lys Ile Arg Lys Gly Lys Pro Gln Gln Leu Leu Arg Val Asp Glu His 
    50                  55                  60                  


Asp Phe Ser Met Arg Pro Ala Phe Gly Gly Pro Ala Ile Pro Val Gly 
65                  70                  75                  80  


Val Asp Val Gln Val Glu Ser Leu Asp Ser Ile Ser Glu Val Asp Met 
                85                  90                  95      


Asp Phe Thr Met Thr Leu Tyr Leu Arg His Tyr Trp Lys Asp Glu Arg 
            100                 105                 110         


Leu Ala Phe Ser Ser Ala Ser Asn Lys Ser Met Thr Phe Asp Gly Arg 
        115                 120                 125             


Leu Val Lys Lys Ile Trp Val Pro Asp Val Phe Phe Val His Ser Lys 
    130                 135                 140                 


Arg Ser Phe Thr His Asp Thr Thr Thr Asp Asn Ile Met Leu Arg Val 
145                 150                 155                 160 


Phe Pro Asp Gly His Val Leu Tyr Ser Met Arg Ile Thr Val Thr Ala 
                165                 170                 175     


Met Cys Asn Met Asp Phe Ser His Phe Pro Leu Asp Ser Gln Thr Cys 
            180                 185                 190         


Ser Leu Glu Leu Glu Ser Tyr Ala Tyr Thr Asp Glu Asp Leu Met Leu 
        195                 200                 205             


Tyr Trp Lys Asn Gly Asp Glu Ser Leu Lys Thr Asp Glu Lys Ile Ser 
    210                 215                 220                 


Leu Ser Gln Phe Leu Ile Gln Lys Phe His Thr Thr Ser Arg Leu Ala 
225                 230                 235                 240 


Phe Tyr Ser Ser Thr Gly Trp Tyr Asn Arg Leu Tyr Ile Asn Phe Thr 
                245                 250                 255     


Leu Arg Arg His Ile Phe Phe Phe Leu Leu Gln Thr Tyr Phe Pro Ala 
            260                 265                 270         


Thr Leu Met Val Met Leu Ser Trp Val Ser Phe Trp Ile Asp Arg Arg 
        275                 280                 285             


Ala Val Pro Ala Arg Val Ser Leu Gly Ile Thr Thr Val Leu Thr Met 
    290                 295                 300                 


Thr Thr Ile Ile Thr Gly Val Asn Ala Ser Met Pro Arg Val Ser Tyr 
305                 310                 315                 320 


Val Lys Ala Val Asp Ile Tyr Leu Trp Val Ser Phe Val Phe Val Phe 
                325                 330                 335     


Leu Ser Val Leu Glu Tyr Ala Ala Val Asn Tyr Leu Thr Thr Val Gln 
            340                 345                 350         


Glu Arg Lys Glu Arg Lys Leu Arg Glu Lys Phe Pro Cys Met Cys Gly 
        355                 360                 365             


Met Leu His Ser Lys Thr Met Met Leu Asp Gly Ser Tyr Ser Glu Ser 
    370                 375                 380                 


Glu Ala Asn Ser Leu Ala Gly Tyr Pro Arg Ser His Ile Leu Thr Glu 
385                 390                 395                 400 


Glu Glu Arg Gln Asp Lys Ile Val Val His Leu Gly Leu Ser Gly Glu 
                405                 410                 415     


Ala Asn Ala Ala Arg Lys Lys Gly Leu Leu Lys Gly Gln Thr Gly Phe 
            420                 425                 430         


Arg Ile Phe Gln Asn Thr His Ala Ile Asp Lys Tyr Ser Arg Leu Ile 
        435                 440                 445             


Phe Pro Ala Ser Tyr Ile Phe Phe Asn Leu Ile Tyr Trp Ser Val Phe 
    450                 455                 460                 


Ser 
465 


<210>  2541
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  2541

Met Lys Ser Ile Tyr Phe Val Ala Gly Leu Phe Val Met Leu Val Gln 
1               5                   10                  15      


Gly Ser Trp Gln Arg Ser Leu Gln Asp Thr Glu Glu Lys Ser Arg Ser 
            20                  25                  30          


Phe Ser Ala Ser Gln Ala Asp Pro Leu Ser Asp Pro Asp Gln Met Asn 
        35                  40                  45              


Glu Asp Lys Arg His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys 
    50                  55                  60                  


Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn 
65                  70                  75                  80  


Thr Lys Arg Asn Arg Asn Asn Ile Ala Lys Arg His Asp Glu Phe Glu 
                85                  90                  95      


Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu 
            100                 105                 110         


Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
        115                 120                 125             


Arg Arg Asp Phe Pro Glu Glu Val Ala Ile Val Glu Glu Leu Gly Arg 
    130                 135                 140                 


Arg His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp 
145                 150                 155                 160 


Asn Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile 
                165                 170                 175     


Thr Asp Arg Lys 
            180 


<210>  2542
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  2542

Met Gly Asp Trp Gly Phe Leu Glu Lys Leu Leu Asp Gln Val Gln Glu 
1               5                   10                  15      


His Ser Thr Val Val Gly Lys Ile Trp Leu Thr Val Leu Phe Ile Phe 
            20                  25                  30          


Arg Ile Leu Ile Leu Gly Leu Ala Gly Glu Ser Val Trp Gly Asp Glu 
        35                  40                  45              


Gln Ser Asp Phe Glu Cys Asn Thr Ala Gln Pro Gly Cys Thr Asn Val 
    50                  55                  60                  


Cys Tyr Asp Gln Ala Phe Pro Ile Ser His Ile Arg Tyr Trp Val Leu 
65                  70                  75                  80  


Gln Phe Leu Phe Val Ser Thr Pro Thr Leu Val Tyr Leu Gly His Val 
                85                  90                  95      


Ile Tyr Leu Ser Arg Arg Glu Glu Arg Leu Arg Gln Lys Glu Gly Glu 
            100                 105                 110         


Leu Arg Ala Leu Pro Ala Lys Asp Pro Gln Val Glu Arg Ala Leu Ala 
        115                 120                 125             


Ala Val Glu Arg Gln Met Ala Lys Ile Ser Val Ala Glu Asp Gly Arg 
    130                 135                 140                 


Leu Arg Ile Arg Gly Ala Leu Met Gly Thr Tyr Val Ala Ser Val Leu 
145                 150                 155                 160 


Cys Lys Ser Val Leu Glu Ala Gly Phe Leu Tyr Gly Gln Trp Arg Leu 
                165                 170                 175     


Tyr Gly Trp Thr Met Glu Pro Val Phe Val Cys Gln Arg Ala Pro Cys 
            180                 185                 190         


Pro Tyr Leu Val Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr Ile 
        195                 200                 205             


Phe Ile Ile Phe Met Leu Val Val Gly Leu Ile Ser Leu Val Leu Asn 
    210                 215                 220                 


Leu Leu Glu Leu Val His Leu Leu Cys Arg Cys Leu Ser Arg Gly Met 
225                 230                 235                 240 


Arg Ala Arg Gln Gly Gln Asp Ala Pro Pro Thr Gln Gly Thr Ser Ser 
                245                 250                 255     


Asp Pro Tyr Thr Asp Gln Val Phe Phe Tyr Leu Pro Val Gly Gln Gly 
            260                 265                 270         


Pro Ser Ser Pro Pro Cys Pro Thr Tyr Asn Gly Leu Ser Ser Ser Glu 
        275                 280                 285             


Gln Asn Trp Ala Asn Leu Thr Thr Glu Glu Arg Leu Ala Ser Ser Arg 
    290                 295                 300                 


Pro Pro Leu Phe Leu Asp Pro Pro Pro Gln Asn Gly Gln Lys Pro Pro 
305                 310                 315                 320 


Ser Arg Pro Ser Ser Ser Ala Ser Lys Lys Gln Tyr Val 
                325                 330             


<210>  2543
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  2543

Met Ala Gly Ala Pro Gly Pro Leu Arg Leu Ala Leu Leu Leu Leu Gly 
1               5                   10                  15      


Met Val Gly Arg Ala Gly Pro Arg Pro Gln Gly Ala Thr Val Ser Leu 
            20                  25                  30          


Trp Glu Thr Val Gln Lys Trp Arg Glu Tyr Arg Arg Gln Cys Gln Arg 
        35                  40                  45              


Ser Leu Thr Glu Asp Pro Pro Pro Ala Thr Asp Leu Phe Cys Asn Arg 
    50                  55                  60                  


Thr Phe Asp Glu Tyr Ala Cys Trp Pro Asp Gly Glu Pro Gly Ser Phe 
65                  70                  75                  80  


Val Asn Val Ser Cys Pro Trp Tyr Leu Pro Trp Ala Ser Ser Val Pro 
                85                  90                  95      


Gln Gly His Val Tyr Arg Phe Cys Thr Ala Glu Gly Leu Trp Leu Gln 
            100                 105                 110         


Lys Asp Asn Ser Ser Leu Pro Trp Arg Asp Leu Ser Glu Cys Glu Glu 
        115                 120                 125             


Ser Lys Arg Gly Glu Arg Ser Ser Pro Glu Glu Gln Leu Leu Phe Leu 
    130                 135                 140                 


Tyr Ile Ile Tyr Thr Val Gly Tyr Ala Leu Ser Phe Ser Ala Leu Val 
145                 150                 155                 160 


Ile Ala Ser Ala Ile Leu Leu Gly Phe Arg His Leu His Cys Thr Arg 
                165                 170                 175     


Asn Tyr Ile His Leu Asn Leu Phe Ala Ser Phe Ile Leu Arg Ala Leu 
            180                 185                 190         


Ser Val Phe Ile Lys Asp Ala Ala Leu Lys Trp Met Tyr Ser Thr Ala 
        195                 200                 205             


Ala Gln Gln His Gln Trp Asp Gly Leu Leu Ser Tyr Gln Asp Ser Leu 
    210                 215                 220                 


Ser Cys Arg Leu Val Phe Leu Leu Met Gln Tyr Cys Val Ala Ala Asn 
225                 230                 235                 240 


Tyr Tyr Trp Leu Leu Val Glu Gly Val Tyr Leu Tyr Thr Leu Leu Ala 
                245                 250                 255     


Phe Ser Val Leu Ser Glu Gln Trp Ile Phe Arg Leu Tyr Val Ser Ile 
            260                 265                 270         


Gly Trp Gly Val Pro Leu Leu Phe Val Val Pro Trp Gly Ile Val Lys 
        275                 280                 285             


Tyr Leu Tyr Glu Asp Glu Gly Cys Trp Thr Arg Asn Ser Asn Met Asn 
    290                 295                 300                 


Tyr Trp Leu Ile Ile Arg Leu Pro Ile Leu Phe Ala Ile Gly Val Asn 
305                 310                 315                 320 


Phe Leu Ile Phe Val Arg Val Ile Cys Ile Val Val Ser Lys Leu Lys 
                325                 330                 335     


Ala Asn Leu Met Cys Lys Thr Asp Ile Lys Cys Arg Leu Ala Lys Ser 
            340                 345                 350         


Thr Leu Thr Leu Ile Pro Leu Leu Gly Thr His Glu Val Ile Phe Ala 
        355                 360                 365             


Phe Val Met Asp Glu His Ala Arg Gly Thr Leu Arg Phe Ile Lys Leu 
    370                 375                 380                 


Phe Thr Glu Leu Ser Phe Thr Ser Phe Gln Gly Leu Met Val Ala Ile 
385                 390                 395                 400 


Leu Tyr Cys Phe Val Asn Asn Glu Val Gln Leu Glu Phe Arg Lys Ser 
                405                 410                 415     


Trp Glu Arg Trp Arg Leu Glu His Leu His Ile Gln Arg Asp Ser Ser 
            420                 425                 430         


Met Lys Pro Leu Lys Cys Pro Thr Ser Ser Leu Ser Ser Gly Ala Thr 
        435                 440                 445             


Ala Gly Ser Ser Met Tyr Thr Ala Thr Cys Gln Ala Ser Cys Ser 
    450                 455                 460             


<210>  2544
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  2544

Met Asn Arg Gln Leu Val Asn Ile Leu Thr Ala Leu Phe Ala Phe Phe 
1               5                   10                  15      


Leu Glu Thr Asn His Phe Arg Thr Ala Phe Cys Lys Asp His Asp Ser 
            20                  25                  30          


Arg Ser Gly Lys Gln Pro Ser Gln Thr Leu Ser Pro Ser Asp Phe Leu 
        35                  40                  45              


Asp Lys Leu Met Gly Arg Thr Ser Gly Tyr Asp Ala Arg Ile Arg Pro 
    50                  55                  60                  


Asn Phe Lys Gly Pro Pro Val Asn Val Thr Cys Asn Ile Phe Ile Asn 
65                  70                  75                  80  


Ser Phe Gly Ser Val Thr Glu Thr Thr Met Asp Tyr Arg Val Asn Ile 
                85                  90                  95      


Phe Leu Arg Gln Gln Trp Asn Asp Ser Arg Leu Ala Tyr Ser Glu Tyr 
            100                 105                 110         


Pro Asp Asp Ser Leu Asp Leu Asp Pro Ser Met Leu Asp Ser Ile Trp 
        115                 120                 125             


Lys Pro Asp Leu Phe Phe Ala Asn Glu Lys Gly Ala Asn Phe His Asp 
    130                 135                 140                 


Val Thr Thr Asp Asn Lys Leu Leu Arg Ile Ser Lys Asn Gly Lys Val 
145                 150                 155                 160 


Leu Tyr Ser Ile Arg Leu Thr Leu Thr Leu Ser Cys Pro Met Asp Leu 
                165                 170                 175     


Lys Asn Phe Pro Met Asp Val Gln Thr Cys Thr Met Gln Leu Glu Ser 
            180                 185                 190         


Phe Gly Tyr Thr Met Asn Asp Leu Ile Phe Glu Trp Leu Ser Asp Gly 
        195                 200                 205             


Pro Val Gln Val Ala Glu Gly Leu Thr Leu Pro Gln Phe Ile Leu Lys 
    210                 215                 220                 


Glu Glu Lys Glu Leu Gly Tyr Cys Thr Lys His Tyr Asn Thr Gly Lys 
225                 230                 235                 240 


Phe Thr Cys Ile Glu Val Lys Phe His Leu Glu Arg Gln Met Gly Tyr 
                245                 250                 255     


Tyr Leu Ile Gln Met Tyr Ile Pro Ser Leu Leu Ile Val Ile Leu Ser 
            260                 265                 270         


Trp Val Ser Phe Trp Ile Asn Met Asp Ala Ala Pro Ala Arg Val Ala 
        275                 280                 285             


Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr Gln Ser Ser Gly Ser 
    290                 295                 300                 


Arg Ala Ser Leu Pro Lys Val Ser Tyr Val Lys Ala Ile Asp Ile Trp 
305                 310                 315                 320 


Met Ala Val Cys Leu Leu Phe Val Phe Ala Ala Leu Leu Glu Tyr Ala 
                325                 330                 335     


Ala Val Asn Phe Val Ser Arg Gln His Lys Glu Phe Leu Arg Leu Arg 
            340                 345                 350         


Arg Arg Gln Lys Arg Gln Asn Lys Glu Glu Asp Val Thr Arg Glu Ser 
        355                 360                 365             


Arg Phe Asn Phe Ser Gly Tyr Gly Met Gly His Cys Leu Gln Val Lys 
    370                 375                 380                 


Asp Gly Thr Ala Val Lys Ala Thr Pro Ala Asn Pro Leu Pro Gln Pro 
385                 390                 395                 400 


Pro Lys Asp Gly Asp Ala Ile Lys Lys Lys Phe Val Asp Arg Ala Lys 
                405                 410                 415     


Arg Ile Asp Thr Ile Ser Arg Ala Ala Phe Pro Leu Ala Phe Leu Ile 
            420                 425                 430         


Phe Asn Ile Phe Tyr Trp Ile Thr Tyr Lys Ile Ile Arg His Glu Asp 
        435                 440                 445             


Val His Lys Lys 
    450         


<210>  2545
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  2545

Met Arg Leu Leu Pro Leu Ala Pro Gly Arg Leu Arg Arg Gly Ser Pro 
1               5                   10                  15      


Arg His Leu Pro Ser Cys Ser Pro Ala Leu Leu Leu Leu Val Leu Gly 
            20                  25                  30          


Gly Cys Leu Gly Val Phe Gly Val Ala Ala Gly Thr Arg Arg Pro Asn 
        35                  40                  45              


Val Val Leu Leu Leu Thr Asp Asp Gln Asp Glu Val Leu Gly Gly Met 
    50                  55                  60                  


Thr Pro Leu Lys Lys Thr Lys Ala Leu Ile Gly Glu Met Gly Met Thr 
65                  70                  75                  80  


Phe Ser Ser Ala Tyr Val Pro Ser Ala Leu Cys Cys Pro Ser Arg Ala 
                85                  90                  95      


Ser Ile Leu Thr Gly Lys Tyr Pro His Asn His His Val Val Asn Asn 
            100                 105                 110         


Thr Leu Glu Gly Asn Cys Ser Ser Lys Ser Trp Gln Lys Ile Gln Glu 
        115                 120                 125             


Pro Asn Thr Phe Pro Ala Ile Leu Arg Ser Met Cys Gly Tyr Gln Thr 
    130                 135                 140                 


Phe Phe Ala Gly Lys Tyr Leu Asn Glu Tyr Gly Ala Pro Asp Ala Gly 
145                 150                 155                 160 


Gly Leu Glu His Val Pro Leu Gly Trp Ser Tyr Trp Tyr Ala Leu Glu 
                165                 170                 175     


Lys Asn Ser Lys Tyr Tyr Asn Tyr Thr Leu Ser Ile Asn Gly Lys Ala 
            180                 185                 190         


Arg Lys His Gly Glu Asn Tyr Ser Val Asp Tyr Leu Thr Asp Val Leu 
        195                 200                 205             


Ala Asn Val Ser Leu Asp Phe Leu Asp Tyr Lys Ser Asn Phe Glu Pro 
    210                 215                 220                 


Phe Phe Met Met Ile Ala Thr Pro Ala Pro His Ser Pro Trp Thr Ala 
225                 230                 235                 240 


Ala Pro Gln Tyr Gln Lys Ala Phe Gln Asn Val Phe Ala Pro Arg Asn 
                245                 250                 255     


Lys Asn Phe Asn Ile His Gly Thr Asn Lys His Trp Leu Ile Arg Gln 
            260                 265                 270         


Ala Lys Thr Pro Met Thr Asn Ser Ser Ile Gln Phe Leu Asp Asn Ala 
        275                 280                 285             


Phe Arg Lys Arg Trp Gln Thr Leu Leu Ser Val Asp Asp Leu Val Glu 
    290                 295                 300                 


Lys Leu Val Lys Arg Leu Glu Phe Thr Gly Glu Leu Asn Asn Thr Tyr 
305                 310                 315                 320 


Ile Phe Tyr Thr Ser Asp Asn Gly Tyr His Thr Gly Gln Phe Ser Leu 
                325                 330                 335     


Pro Ile Asp Lys Arg Gln Leu Tyr Glu Phe Asp Ile Lys Val Pro Leu 
            340                 345                 350         


Leu Val Arg Gly Pro Gly Ile Lys Pro Asn Gln Thr Ser Lys Met Leu 
        355                 360                 365             


Val Ala Asn Ile Asp Leu Gly Pro Thr Ile Leu Asp Ile Ala Gly Tyr 
    370                 375                 380                 


Asp Leu Asn Lys Thr Gln Met Asp Gly Met Ser Leu Leu Pro Ile Leu 
385                 390                 395                 400 


Arg Gly Ala Ser Asn Leu Thr Trp Arg Ser Asp Val Leu Val Glu Tyr 
                405                 410                 415     


Gln Gly Glu Gly Arg Asn Val Thr Asp Pro Thr Cys Pro Ser Leu Ser 
            420                 425                 430         


Pro Gly Val Ser Gln Cys Phe Pro Asp Cys Val Cys Glu Asp Ala Tyr 
        435                 440                 445             


Asn Asn Thr Tyr Ala Cys Val Arg Thr Met Ser Ala Leu Trp Asn Leu 
    450                 455                 460                 


Gln Tyr Cys Glu Phe Asp Asp Gln Glu Val Phe Val Glu Val Tyr Asn 
465                 470                 475                 480 


Leu Thr Ala Asp Pro Asp Gln Ile Thr Asn Ile Ala Lys Thr Ile Asp 
                485                 490                 495     


Pro Glu Leu Leu Gly Lys Met Asn Tyr Arg Leu Met Met Leu Gln Ser 
            500                 505                 510         


Cys Ser Gly Pro Thr Cys Arg Thr Pro Gly Val Phe Asp Pro Gly Tyr 
        515                 520                 525             


Arg Phe Asp Pro Arg Leu Met Phe Ser Asn Arg Gly Ser Val Arg Thr 
    530                 535                 540                 


Arg Arg Phe Ser Lys His Leu Leu 
545                 550         


<210>  2546
<211>  980
<212>  PRT
<213>  Homo sapiens

<400>  2546

Met Pro Ala Glu Leu Leu Leu Leu Leu Ile Val Ala Phe Ala Ser Pro 
1               5                   10                  15      


Ser Cys Gln Val Leu Ser Ser Leu Arg Met Ala Ala Ile Leu Asp Asp 
            20                  25                  30          


Gln Thr Val Cys Gly Arg Gly Glu Arg Leu Ala Leu Ala Leu Ala Arg 
        35                  40                  45              


Glu Gln Ile Asn Gly Ile Ile Glu Val Pro Ala Lys Ala Arg Val Glu 
    50                  55                  60                  


Val Asp Ile Phe Glu Leu Gln Arg Asp Ser Gln Tyr Glu Thr Thr Asp 
65                  70                  75                  80  


Thr Met Cys Gln Ile Leu Pro Lys Gly Val Val Ser Val Leu Gly Pro 
                85                  90                  95      


Ser Ser Ser Pro Ala Ser Ala Ser Thr Val Ser His Ile Cys Gly Glu 
            100                 105                 110         


Lys Glu Ile Pro His Ile Lys Val Gly Pro Glu Glu Thr Pro Arg Leu 
        115                 120                 125             


Gln Tyr Leu Arg Phe Ala Ser Val Ser Leu Tyr Pro Ser Asn Glu Asp 
    130                 135                 140                 


Val Ser Leu Ala Val Ser Arg Ile Leu Lys Ser Phe Asn Tyr Pro Ser 
145                 150                 155                 160 


Ala Ser Leu Ile Cys Ala Lys Ala Glu Cys Leu Leu Arg Leu Glu Glu 
                165                 170                 175     


Leu Val Arg Gly Phe Leu Ile Ser Lys Glu Thr Leu Ser Val Arg Met 
            180                 185                 190         


Leu Asp Asp Ser Arg Asp Pro Thr Pro Leu Leu Lys Glu Ile Arg Asp 
        195                 200                 205             


Asp Lys Val Ser Thr Ile Ile Ile Asp Ala Asn Ala Ser Ile Ser His 
    210                 215                 220                 


Leu Ile Leu Arg Lys Ala Ser Glu Leu Gly Met Thr Ser Ala Phe Tyr 
225                 230                 235                 240 


Lys Tyr Ile Leu Thr Thr Met Asp Phe Pro Ile Leu His Leu Asp Gly 
                245                 250                 255     


Ile Val Glu Asp Ser Ser Asn Ile Leu Gly Phe Ser Met Phe Asn Thr 
            260                 265                 270         


Ser His Pro Phe Tyr Pro Glu Phe Val Arg Ser Leu Asn Met Ser Trp 
        275                 280                 285             


Arg Glu Asn Cys Glu Ala Ser Thr Tyr Leu Gly Pro Ala Leu Ser Ala 
    290                 295                 300                 


Ala Leu Met Phe Asp Ala Val His Val Val Val Ser Ala Val Arg Glu 
305                 310                 315                 320 


Leu Asn Arg Ser Gln Glu Ile Gly Val Lys Pro Leu Ala Cys Thr Ser 
                325                 330                 335     


Ala Asn Ile Trp Pro His Gly Thr Ser Leu Met Asn Tyr Leu Arg Met 
            340                 345                 350         


Val Glu Tyr Asp Gly Leu Thr Gly Arg Val Glu Phe Asn Ser Lys Gly 
        355                 360                 365             


Gln Arg Thr Asn Tyr Thr Leu Arg Ile Leu Glu Lys Ser Arg Gln Gly 
    370                 375                 380                 


His Arg Glu Ile Gly Val Trp Tyr Ser Asn Arg Thr Leu Ala Met Asn 
385                 390                 395                 400 


Ala Thr Thr Leu Asp Ile Asn Leu Ser Gln Thr Leu Ala Asn Lys Thr 
                405                 410                 415     


Leu Val Val Thr Thr Ile Leu Glu Asn Pro Tyr Val Met Arg Arg Pro 
            420                 425                 430         


Asn Phe Gln Ala Leu Ser Gly Asn Glu Arg Phe Glu Gly Phe Cys Val 
        435                 440                 445             


Asp Met Leu Arg Glu Leu Ala Glu Leu Leu Arg Phe Arg Tyr Arg Leu 
    450                 455                 460                 


Arg Leu Val Glu Asp Gly Leu Tyr Gly Ala Pro Glu Pro Asn Gly Ser 
465                 470                 475                 480 


Trp Thr Gly Met Val Gly Glu Leu Ile Asn Arg Lys Ala Asp Leu Ala 
                485                 490                 495     


Val Ala Ala Phe Thr Ile Thr Ala Glu Arg Glu Lys Val Ile Asp Phe 
            500                 505                 510         


Ser Lys Pro Phe Met Thr Leu Gly Ile Ser Ile Leu Tyr Arg Val His 
        515                 520                 525             


Met Gly Arg Lys Pro Gly Tyr Phe Ser Phe Leu Asp Pro Phe Ser Pro 
    530                 535                 540                 


Ala Val Trp Leu Phe Met Leu Leu Ala Tyr Leu Ala Val Ser Cys Val 
545                 550                 555                 560 


Leu Phe Leu Ala Ala Arg Leu Ser Pro Tyr Glu Trp Tyr Asn Pro His 
                565                 570                 575     


Pro Cys Leu Arg Ala Arg Pro His Ile Leu Glu Asn Gln Tyr Thr Leu 
            580                 585                 590         


Gly Asn Ser Leu Trp Phe Pro Val Gly Gly Phe Met Gln Gln Gly Ser 
        595                 600                 605             


Glu Ile Met Pro Arg Ala Leu Ser Thr Arg Cys Val Ser Gly Val Trp 
    610                 615                 620                 


Trp Ala Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala 
625                 630                 635                 640 


Ala Phe Leu Thr Val Gln Arg Met Glu Val Pro Val Glu Ser Ala Asp 
                645                 650                 655     


Asp Leu Ala Asp Gln Thr Asn Ile Glu Tyr Gly Thr Ile His Ala Gly 
            660                 665                 670         


Ser Thr Met Thr Phe Phe Gln Asn Ser Arg Tyr Gln Thr Tyr Gln Arg 
        675                 680                 685             


Met Trp Asn Tyr Met Gln Ser Lys Gln Pro Ser Val Phe Val Lys Ser 
    690                 695                 700                 


Thr Glu Glu Gly Ile Ala Arg Val Leu Asn Ser Arg Tyr Ala Phe Leu 
705                 710                 715                 720 


Leu Glu Ser Thr Met Asn Glu Tyr His Arg Arg Leu Asn Cys Asn Leu 
                725                 730                 735     


Thr Gln Ile Gly Gly Leu Leu Asp Thr Lys Gly Tyr Gly Ile Gly Met 
            740                 745                 750         


Pro Leu Gly Ser Pro Phe Arg Asp Glu Ile Thr Leu Ala Ile Leu Gln 
        755                 760                 765             


Leu Gln Glu Asn Asn Arg Leu Glu Ile Leu Lys Arg Lys Trp Trp Glu 
    770                 775                 780                 


Gly Gly Arg Cys Pro Lys Glu Glu Asp His Arg Ala Lys Gly Leu Gly 
785                 790                 795                 800 


Met Glu Asn Ile Gly Gly Ile Phe Ile Val Leu Ile Cys Gly Leu Ile 
                805                 810                 815     


Ile Ala Val Phe Val Ala Val Met Glu Phe Ile Trp Ser Thr Arg Arg 
            820                 825                 830         


Ser Ala Glu Ser Glu Glu Val Ser Val Cys Gln Glu Met Leu Gln Glu 
        835                 840                 845             


Leu Arg His Ala Val Ser Cys Arg Lys Thr Ser Arg Ser Arg Arg Arg 
    850                 855                 860                 


Arg Arg Pro Gly Gly Pro Ser Arg Ala Leu Leu Ser Leu Arg Ala Val 
865                 870                 875                 880 


Arg Glu Met Arg Leu Ser Asn Gly Lys Leu Tyr Ser Ala Gly Ala Gly 
                885                 890                 895     


Gly Asp Ala Gly Ser Ala His Gly Gly Pro Gln Arg Leu Leu Asp Asp 
            900                 905                 910         


Pro Gly Pro Pro Ser Gly Ala Arg Pro Ala Ala Pro Thr Pro Cys Thr 
        915                 920                 925             


His Val Arg Val Cys Gln Glu Cys Arg Arg Ile Gln Ala Leu Arg Ala 
    930                 935                 940                 


Ser Gly Ala Gly Ala Pro Pro Arg Gly Leu Gly Val Pro Ala Glu Ala 
945                 950                 955                 960 


Thr Ser Pro Pro Arg Pro Arg Pro Gly Pro Ala Gly Pro Arg Glu Leu 
                965                 970                 975     


Ala Glu His Glu 
            980 


<210>  2547
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  2547

Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Leu Ser Thr Thr Glu Val Ala Met His Thr Ser Thr Ser 
            20                  25                  30          


Ser Ser Val Thr Lys Ser Tyr Ile Ser Ser Gln Thr Asn Asp Thr His 
        35                  40                  45              


Lys Arg Asp Thr Tyr Ala Ala Thr Pro Arg Ala His Glu Val Ser Glu 
    50                  55                  60                  


Ile Ser Val Arg Thr Val Tyr Pro Pro Glu Glu Glu Thr Gly Glu Arg 
65                  70                  75                  80  


Val Gln Leu Ala His His Phe Ser Glu Pro Glu Ile Thr Leu Ile Ile 
                85                  90                  95      


Phe Gly Val Met Ala Gly Val Ile Gly Thr Ile Leu Leu Ile Ser Tyr 
            100                 105                 110         


Gly Ile Arg Arg Leu Ile Lys Lys Ser Pro Ser Asp Val Lys Pro Leu 
        115                 120                 125             


Pro Ser Pro Asp Thr Asp Val Pro Leu Ser Ser Val Glu Ile Glu Asn 
    130                 135                 140                 


Pro Glu Thr Ser Asp Gln 
145                 150 


<210>  2548
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  2548

Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Leu Ser Thr Thr Glu Val Ala Met His Thr Ser Thr Ser 
            20                  25                  30          


Ser Ser Val Thr Lys Ser Tyr Ile Ser Ser Gln Thr Asn Gly Glu Thr 
        35                  40                  45              


Gly Gln Leu Val His Arg Phe Thr Val Pro Ala Pro Val Val Ile Ile 
    50                  55                  60                  


Leu Ile Ile Leu Cys Val Met Ala Gly Ile Ile Gly Thr Ile Leu Leu 
65                  70                  75                  80  


Ile Ser Tyr Thr Ile Arg Arg Leu Ile Lys Ala 
                85                  90      


<210>  2549
<211>  78
<212>  PRT
<213>  Homo sapiens

<400>  2549

Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Gly Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Ser Ser Thr Thr Gly Val Ala Met His Thr Ser Thr Ser 
            20                  25                  30          


Ser Ser Val Thr Lys Ser Tyr Ile Ser Ser Gln Thr Asn Gly Ile Thr 
        35                  40                  45              


Leu Ile Asn Trp Trp Ala Met Ala Arg Val Ile Phe Glu Val Met Leu 
    50                  55                  60                  


Val Val Val Gly Met Ile Ile Leu Ile Ser Tyr Cys Ile Arg 
65                  70                  75              


<210>  2550
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  2550

Met Thr Lys Phe Ser Ser Phe Ser Leu Phe Phe Leu Ile Val Gly Ala 
1               5                   10                  15      


Tyr Met Thr His Val Cys Phe Asn Met Glu Ile Ile Gly Gly Lys Glu 
            20                  25                  30          


Val Ser Pro His Ser Arg Pro Phe Met Ala Ser Ile Gln Tyr Gly Gly 
        35                  40                  45              


His His Val Cys Gly Gly Val Leu Ile Asp Pro Gln Trp Val Leu Thr 
    50                  55                  60                  


Ala Ala His Cys Gln Tyr Arg Phe Thr Lys Gly Gln Ser Pro Thr Val 
65                  70                  75                  80  


Val Leu Gly Ala His Ser Leu Ser Lys Asn Glu Ala Ser Lys Gln Thr 
                85                  90                  95      


Leu Glu Ile Lys Lys Phe Ile Pro Phe Ser Arg Val Thr Ser Asp Pro 
            100                 105                 110         


Gln Ser Asn Asp Ile Met Leu Val Lys Leu Gln Thr Ala Ala Lys Leu 
        115                 120                 125             


Asn Lys His Val Lys Met Leu His Ile Arg Ser Lys Thr Ser Leu Arg 
    130                 135                 140                 


Ser Gly Thr Lys Cys Lys Val Thr Gly Trp Gly Ala Thr Asp Pro Asp 
145                 150                 155                 160 


Ser Leu Arg Pro Ser Asp Thr Leu Arg Glu Val Thr Val Thr Val Leu 
                165                 170                 175     


Ser Arg Lys Leu Cys Asn Ser Gln Ser Tyr Tyr Asn Gly Asp Pro Phe 
            180                 185                 190         


Ile Thr Lys Asp Met Val Cys Ala Gly Asp Ala Lys Gly Gln Lys Asp 
        195                 200                 205             


Ser Cys Lys Gly Asp Ser Gly Gly Pro Leu Ile Cys Lys Gly Val Phe 
    210                 215                 220                 


His Ala Ile Val Ser Gly Gly His Glu Cys Gly Val Ala Thr Lys Pro 
225                 230                 235                 240 


Gly Ile Tyr Thr Leu Leu Thr Lys Lys Tyr Gln Thr Trp Ile Lys Ser 
                245                 250                 255     


Asn Leu Val Pro Pro His Thr Asn 
            260                 


<210>  2551
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  2551

Met Arg Val Met Ala Pro Arg Ala Leu Leu Leu Leu Leu Ser Gly Gly 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Cys Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Asp Thr Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Gly Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Lys Tyr Lys Arg Gln Ala Gln 
                85                  90                  95      


Ala Asp Arg Val Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Asp Gly Ser His Thr Leu Gln Arg Met Ser Gly Cys Asp Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr Asp Gln Ser Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Leu Glu Ala Ala Arg Ala 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Leu Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Met Gln His Glu 
        275                 280                 285             


Gly Leu Gln Glu Pro Leu Thr Leu Ser Trp Glu Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Ala Val Leu Val Val 
305                 310                 315                 320 


Leu Ala Val Leu Gly Ala Val Val Thr Ala Met Met Cys Arg Arg Lys 
                325                 330                 335     


Ser Ser Gly Gly Lys Gly Gly Ser Cys Ser Gln Ala Ala Cys Ser Asn 
            340                 345                 350         


Ser Ala Gln Gly Ser Asp Glu Ser Leu Ile Thr Cys Lys Ala 
        355                 360                 365     


<210>  2552
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  2552

Met Leu Val Met Ala Pro Arg Thr Val Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Tyr Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Asn Thr Gln Ile Tyr Lys Ala Gln Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Ser Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly His Asp Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 
                165                 170                 175     


Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Asp Lys Leu Glu Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  2553
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  2553

Met Ile Thr Phe Leu Pro Leu Leu Leu Gly Leu Ser Leu Gly Cys Thr 
1               5                   10                  15      


Gly Ala Gly Gly Phe Val Ala His Val Glu Ser Thr Cys Leu Leu Asp 
            20                  25                  30          


Asp Ala Gly Thr Pro Lys Asp Phe Thr Tyr Cys Ile Ser Phe Asn Lys 
        35                  40                  45              


Asp Leu Leu Thr Cys Trp Asp Pro Glu Glu Asn Lys Met Ala Pro Cys 
    50                  55                  60                  


Glu Phe Gly Val Leu Asn Ser Leu Ala Asn Val Leu Ser Gln His Leu 
65                  70                  75                  80  


Asn Gln Lys Asp Thr Leu Met Gln Arg Leu Arg Asn Gly Leu Gln Asn 
                85                  90                  95      


Cys Ala Thr His Thr Gln Pro Phe Trp Gly Ser Leu Thr Asn Arg Thr 
            100                 105                 110         


Arg Pro Pro Ser Val Gln Val Ala Lys Thr Thr Pro Phe Asn Thr Arg 
        115                 120                 125             


Glu Pro Val Met Leu Ala Cys Tyr Val Trp Gly Phe Tyr Pro Ala Glu 
    130                 135                 140                 


Val Thr Ile Thr Trp Arg Lys Asn Gly Lys Leu Val Met Pro His Ser 
145                 150                 155                 160 


Ser Ala His Lys Thr Ala Gln Pro Asn Gly Asp Trp Thr Tyr Gln Thr 
                165                 170                 175     


Leu Ser His Leu Ala Leu Thr Pro Ser Tyr Gly Asp Thr Tyr Thr Cys 
            180                 185                 190         


Val Val Glu His Thr Gly Ala Pro Glu Pro Ile Leu Arg Asp Trp Thr 
        195                 200                 205             


Pro Gly Leu Ser Pro Met Gln Thr Leu Lys Val Ser Val Ser Ala Val 
    210                 215                 220                 


Thr Leu Gly Leu Gly Leu Ile Ile Phe Ser Leu Gly Val Ile Ser Trp 
225                 230                 235                 240 


Arg Arg Ala Gly His Ser Ser Tyr Thr Pro Leu Pro Gly Ser Asn Tyr 
                245                 250                 255     


Ser Glu Gly Trp His Ile Ser 
            260             


<210>  2554
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  2554

Met Ala Leu Arg Ala Gly Leu Val Leu Gly Phe His Thr Leu Met Thr 
1               5                   10                  15      


Leu Leu Ser Pro Gln Glu Ala Gly Ala Thr Lys Ala Asp His Met Gly 
            20                  25                  30          


Ser Tyr Gly Pro Ala Phe Tyr Gln Ser Tyr Gly Ala Ser Gly Gln Phe 
        35                  40                  45              


Thr His Glu Phe Asp Glu Glu Gln Leu Phe Ser Val Asp Leu Lys Lys 
    50                  55                  60                  


Ser Glu Ala Val Trp Arg Leu Pro Glu Phe Gly Asp Phe Ala Arg Phe 
65                  70                  75                  80  


Asp Pro Gln Gly Gly Leu Ala Gly Ile Ala Ala Ile Lys Ala His Leu 
                85                  90                  95      


Asp Ile Leu Val Glu Arg Ser Asn Arg Ser Arg Ala Ile Asn Val Pro 
            100                 105                 110         


Pro Arg Val Thr Val Leu Pro Lys Ser Arg Val Glu Leu Gly Gln Pro 
        115                 120                 125             


Asn Ile Leu Ile Cys Ile Val Asp Asn Ile Phe Pro Pro Val Ile Asn 
    130                 135                 140                 


Ile Thr Trp Leu Arg Asn Gly Gln Thr Val Thr Glu Gly Val Ala Gln 
145                 150                 155                 160 


Thr Ser Phe Tyr Ser Gln Pro Asp His Leu Phe Arg Lys Phe His Tyr 
                165                 170                 175     


Leu Pro Phe Val Pro Ser Ala Glu Asp Val Tyr Asp Cys Gln Val Glu 
            180                 185                 190         


His Trp Gly Leu Asp Ala Pro Leu Leu Arg His Trp Glu Leu Gln Val 
        195                 200                 205             


Pro Ile Pro Pro Pro Asp Ala Met Glu Thr Leu Val Cys Ala Leu Gly 
    210                 215                 220                 


Leu Ala Ile Gly Leu Val Gly Phe Leu Val Gly Thr Val Leu Ile Ile 
225                 230                 235                 240 


Met Gly Thr Tyr Val Ser Ser Val Pro Arg 
                245                 250 


<210>  2555
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  2555

Met Gly Ser Gly Trp Val Pro Trp Val Val Ala Leu Leu Val Asn Leu 
1               5                   10                  15      


Thr Arg Leu Asp Ser Ser Met Thr Gln Gly Thr Asp Ser Pro Glu Asp 
            20                  25                  30          


Phe Val Ile Gln Ala Lys Ala Asp Cys Tyr Phe Thr Asn Gly Thr Glu 
        35                  40                  45              


Lys Val Gln Phe Val Val Arg Phe Ile Phe Asn Leu Glu Glu Tyr Val 
    50                  55                  60                  


Arg Phe Asp Ser Asp Val Gly Met Phe Val Ala Leu Thr Lys Leu Gly 
65                  70                  75                  80  


Gln Pro Asp Ala Glu Gln Trp Asn Ser Arg Leu Asp Leu Leu Glu Arg 
                85                  90                  95      


Ser Arg Gln Ala Val Asp Gly Val Cys Arg His Asn Tyr Arg Leu Gly 
            100                 105                 110         


Ala Pro Phe Thr Val Gly Arg Lys Val Gln Pro Glu Val Thr Val Tyr 
        115                 120                 125             


Pro Glu Arg Thr Pro Leu Leu His Gln His Asn Leu Leu His Cys Ser 
    130                 135                 140                 


Val Thr Gly Phe Tyr Pro Gly Asp Ile Lys Ile Lys Trp Phe Leu Asn 
145                 150                 155                 160 


Gly Gln Glu Glu Arg Ala Gly Val Met Ser Thr Gly Pro Ile Arg Asn 
                165                 170                 175     


Gly Asp Trp Thr Phe Gln Thr Val Val Met Leu Glu Met Thr Pro Glu 
            180                 185                 190         


Leu Gly His Val Tyr Thr Cys Leu Val Asp His Ser Ser Leu Leu Ser 
        195                 200                 205             


Pro Val Ser Val Glu Trp Arg Ala Gln Ser Glu Tyr Ser Trp Arg Lys 
    210                 215                 220                 


Met Leu Ser Gly Ile Ala Ala Phe Leu Leu Gly Leu Ile Phe Leu Leu 
225                 230                 235                 240 


Val Gly Ile Val Ile Gln Leu Arg Ala Gln Lys Gly Tyr Val Arg Thr 
                245                 250                 255     


Gln Met Ser Gly Asn Glu Val Ser Arg Ala Val Leu Leu Pro Gln Ser 
            260                 265                 270         


Cys 
    


<210>  2556
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  2556

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Thr Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ser Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Trp Gln Pro Lys Arg Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile 
                85                  90                  95      


Leu Glu Gln Ala Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Gln Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Leu Asn Gly Gln Glu Glu Lys Ala Gly Met Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  2557
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  2557

Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Thr Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Ser Ala Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Met Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ser 
    50                  55                  60                  


Ala Cys Pro Arg Met Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Glu Glu Glu Thr Arg Asn Thr Lys Ala His Ala Gln 
                85                  90                  95      


Thr Asp Arg Met Asn Leu Gln Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Ser Ser His Thr Leu Gln Trp Met Ile Gly Cys Asp Leu Gly 
        115                 120                 125             


Ser Asp Gly Arg Leu Leu Arg Gly Tyr Glu Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Lys Arg Lys Cys Glu Ala Ala Asn Val 
                165                 170                 175     


Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Arg Tyr Leu Glu Asn Gly Lys Glu Met Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Val Phe Asp Tyr Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Ile Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Val Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Leu Met Leu Arg Trp Lys Gln Ser Ser Leu Pro 
    290                 295                 300                 


Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Val Val Leu Ala Ala 
305                 310                 315                 320 


Val Val Thr Gly Ala Ala Val Ala Ala Val Leu Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Asp 
        


<210>  2558
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  2558

Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu Ser Glu Ala 
1               5                   10                  15      


Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp Gly Phe Lys 
        35                  40                  45              


Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu Glu Glu Glu 
    50                  55                  60                  


Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val Tyr Phe Pro 
65                  70                  75                  80  


Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu Ala Phe Trp 
                85                  90                  95      


Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro Ala Met Gln 
            100                 105                 110         


Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu Pro Glu Leu 
        115                 120                 125             


Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu Ser Gly Gly 
    130                 135                 140                 


Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu Pro Ser Ser 
145                 150                 155                 160 


Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala Ser Ala Thr 
                165                 170                 175     


Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu Glu Met Thr 
            180                 185                 190         


Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr Ala Phe Leu 
        195                 200                 205             


Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu Thr His Asp 
    210                 215                 220                 


Thr Lys Asp Gln Ser Pro Ser Arg Ala Pro Gly Leu Arg Gln Arg Ala 
225                 230                 235                 240 


Ser Asn Lys Val Gln Asp Ser Ala Pro Val Glu Thr Pro Arg Gly Lys 
                245                 250                 255     


Pro Pro Leu Asn Thr Arg Ser Gln Ala Pro Leu Leu Arg Trp Val Leu 
            260                 265                 270         


Thr Leu Ser Phe Leu Val Ala Thr Val Ala Val Gly Leu Tyr Ala Met 
        275                 280                 285             


<210>  2559
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  2559

Met Ser Ala Glu Val Glu Thr Ser Glu Gly Val Asp Glu Ser Glu Lys 
1               5                   10                  15      


Lys Asn Ser Gly Ala Leu Glu Lys Glu Asn Gln Met Arg Met Ala Asp 
            20                  25                  30          


Leu Ser Glu Leu Leu Lys Glu Gly Thr Lys Glu Ala His Asp Arg Ala 
        35                  40                  45              


Glu Asn Thr Gln Phe Val Lys Asp Phe Leu Lys Gly Asn Ile Lys Lys 
    50                  55                  60                  


Glu Leu Phe Lys Leu Ala Thr Thr Ala Leu Tyr Phe Thr Tyr Ser Ala 
65                  70                  75                  80  


Leu Glu Glu Glu Met Glu Arg Asn Lys Asp His Pro Ala Phe Ala Pro 
                85                  90                  95      


Leu Tyr Phe Pro Met Glu Leu His Arg Lys Glu Ala Leu Thr Lys Asp 
            100                 105                 110         


Met Glu Tyr Phe Phe Gly Glu Asn Trp Glu Glu Gln Val Gln Cys Pro 
        115                 120                 125             


Lys Ala Ala Gln Lys Tyr Val Glu Arg Ile His Tyr Ile Gly Gln Asn 
    130                 135                 140                 


Glu Pro Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Met Gly Asp 
145                 150                 155                 160 


Leu Ser Gly Gly Gln Val Leu Lys Lys Val Ala Gln Arg Ala Leu Lys 
                165                 170                 175     


Leu Pro Ser Thr Gly Glu Gly Thr Gln Phe Tyr Leu Phe Glu Asn Val 
            180                 185                 190         


Asp Asn Ala Gln Gln Phe Lys Gln Leu Tyr Arg Ala Arg Met Asn Ala 
        195                 200                 205             


Leu Asp Leu Asn Met Lys Thr Lys Glu Arg Ile Val Glu Glu Ala Asn 
    210                 215                 220                 


Lys Ala Phe Glu Tyr Asn Met Gln Ile Phe Asn Glu Leu Asp Gln Ala 
225                 230                 235                 240 


Gly Ser Thr Leu Ala Arg Glu Thr Leu Glu Asp Gly Phe Pro Val His 
                245                 250                 255     


Asp Gly Lys Gly Asp Met Arg Lys Cys Pro Phe Tyr Ala Ala Glu Gln 
            260                 265                 270         


Asp Lys Gly Ala Leu Glu Gly Ser Ser Cys Pro Phe Arg Thr Ala Met 
        275                 280                 285             


Ala Val Leu Arg Lys Pro Ser Leu Gln Phe Ile Leu Ala Ala Gly Val 
    290                 295                 300                 


Ala Leu Ala Ala Gly Leu Leu Ala Trp Tyr Tyr Met 
305                 310                 315     


<210>  2560
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  2560

Met Ala Gln Lys Glu Gly Gly Arg Thr Val Pro Cys Cys Ser Arg Pro 
1               5                   10                  15      


Lys Val Ala Ala Leu Thr Ala Gly Thr Leu Leu Leu Leu Thr Ala Ile 
            20                  25                  30          


Gly Ala Ala Ser Trp Ala Ile Val Ala Val Leu Leu Arg Ser Asp Gln 
        35                  40                  45              


Glu Pro Leu Tyr Pro Val Gln Val Ser Ser Ala Asp Ala Arg Leu Met 
    50                  55                  60                  


Val Phe Asp Lys Thr Glu Gly Thr Trp Arg Leu Leu Cys Ser Ser Arg 
65                  70                  75                  80  


Ser Asn Ala Arg Val Ala Gly Leu Ser Cys Glu Glu Met Gly Phe Leu 
                85                  90                  95      


Arg Ala Leu Thr His Ser Glu Leu Asp Val Arg Thr Ala Gly Ala Asn 
            100                 105                 110         


Gly Thr Ser Gly Phe Phe Cys Val Asp Glu Gly Arg Leu Pro His Thr 
        115                 120                 125             


Gln Arg Leu Leu Glu Val Ile Ser Val Cys Asp Cys Pro Arg Gly Arg 
    130                 135                 140                 


Phe Leu Ala Ala Ile Cys Gln Asp Cys Gly Arg Arg Lys Leu Pro Val 
145                 150                 155                 160 


Asp Arg Ile Val Gly Gly Arg Asp Thr Ser Leu Gly Arg Trp Pro Trp 
                165                 170                 175     


Gln Val Ser Leu Arg Tyr Asp Gly Ala His Leu Cys Gly Gly Ser Leu 
            180                 185                 190         


Leu Ser Gly Asp Trp Val Leu Thr Ala Ala His Cys Phe Pro Glu Arg 
        195                 200                 205             


Asn Arg Val Leu Ser Arg Trp Arg Val Phe Ala Gly Ala Val Ala Gln 
    210                 215                 220                 


Ala Ser Pro His Gly Leu Gln Leu Gly Val Gln Ala Val Val Tyr His 
225                 230                 235                 240 


Gly Gly Tyr Leu Pro Phe Arg Asp Pro Asn Ser Glu Glu Asn Ser Asn 
                245                 250                 255     


Asp Ile Ala Leu Val His Leu Ser Ser Pro Leu Pro Leu Thr Glu Tyr 
            260                 265                 270         


Ile Gln Pro Val Cys Leu Pro Ala Ala Gly Gln Ala Leu Val Asp Gly 
        275                 280                 285             


Lys Ile Cys Thr Val Thr Gly Trp Gly Asn Thr Gln Tyr Tyr Gly Gln 
    290                 295                 300                 


Gln Ala Gly Val Leu Gln Glu Ala Arg Val Pro Ile Ile Ser Asn Asp 
305                 310                 315                 320 


Val Cys Asn Gly Ala Asp Phe Tyr Gly Asn Gln Ile Lys Pro Lys Met 
                325                 330                 335     


Phe Cys Ala Gly Tyr Pro Glu Gly Gly Ile Asp Ala Cys Gln Gly Asp 
            340                 345                 350         


Ser Gly Gly Pro Phe Val Cys Glu Asp Ser Ile Ser Arg Thr Pro Arg 
        355                 360                 365             


Trp Arg Leu Cys Gly Ile Val Ser Trp Gly Thr Gly Cys Ala Leu Ala 
    370                 375                 380                 


Gln Lys Pro Gly Val Tyr Thr Lys Val Ser Asp Phe Arg Glu Trp Ile 
385                 390                 395                 400 


Phe Gln Ala Ile Lys Thr His Ser Glu Ala Ser Gly Met Val Thr Gln 
                405                 410                 415     


Leu 
    


<210>  2561
<211>  387
<212>  PRT
<213>  Homo sapiens

<400>  2561

Met Ser Thr Phe Phe Ser Asp Thr Ala Trp Ile Cys Leu Ala Val Pro 
1               5                   10                  15      


Thr Val Leu Cys Gly Thr Val Phe Cys Lys Tyr Lys Lys Ser Ser Gly 
            20                  25                  30          


Gln Leu Trp Ser Trp Met Val Cys Leu Ala Gly Leu Cys Ala Val Cys 
        35                  40                  45              


Leu Leu Ile Leu Ser Pro Phe Trp Gly Leu Ile Leu Phe Ser Val Ser 
    50                  55                  60                  


Cys Phe Leu Met Tyr Thr Tyr Leu Ser Gly Gln Glu Leu Leu Pro Val 
65                  70                  75                  80  


Asp Gln Lys Ala Val Leu Val Thr Gly Gly Asp Cys Gly Leu Gly His 
                85                  90                  95      


Ala Leu Cys Lys Tyr Leu Asp Glu Leu Gly Phe Thr Val Phe Ala Gly 
            100                 105                 110         


Val Leu Asn Glu Asn Gly Pro Gly Ala Glu Glu Leu Arg Arg Thr Cys 
        115                 120                 125             


Ser Pro Arg Leu Ser Val Leu Gln Met Asp Ile Thr Lys Pro Val Gln 
    130                 135                 140                 


Ile Lys Asp Ala Tyr Ser Lys Val Ala Ala Met Leu Gln Asp Arg Gly 
145                 150                 155                 160 


Leu Trp Ala Val Ile Asn Asn Ala Gly Val Leu Gly Phe Pro Thr Asp 
                165                 170                 175     


Gly Glu Leu Leu Leu Met Thr Asp Tyr Lys Gln Cys Met Ala Val Asn 
            180                 185                 190         


Phe Phe Gly Thr Val Glu Val Thr Lys Thr Phe Leu Pro Leu Leu Arg 
        195                 200                 205             


Lys Ser Lys Gly Arg Leu Val Asn Val Ser Ser Met Gly Gly Gly Ala 
    210                 215                 220                 


Pro Met Glu Arg Leu Ala Ser Tyr Gly Ser Ser Lys Ala Ala Val Thr 
225                 230                 235                 240 


Met Phe Ser Ser Val Met Arg Leu Glu Leu Ser Lys Trp Gly Ile Lys 
                245                 250                 255     


Val Ala Ser Ile Gln Pro Gly Gly Phe Leu Thr Asn Ile Ala Gly Thr 
            260                 265                 270         


Ser Asp Lys Trp Glu Lys Leu Glu Lys Asp Ile Leu Asp His Leu Pro 
        275                 280                 285             


Ala Glu Val Gln Glu Asp Tyr Gly Gln Asp Tyr Ile Leu Ala Gln Arg 
    290                 295                 300                 


Asn Phe Leu Leu Leu Ile Asn Ser Leu Ala Ser Lys Asp Phe Ser Pro 
305                 310                 315                 320 


Val Leu Arg Asp Ile Gln His Ala Ile Leu Ala Lys Ser Pro Phe Ala 
                325                 330                 335     


Tyr Tyr Thr Pro Gly Lys Gly Ala Tyr Leu Trp Ile Cys Leu Ala His 
            340                 345                 350         


Tyr Leu Pro Ile Gly Ile Tyr Asp Tyr Phe Ala Lys Arg His Phe Gly 
        355                 360                 365             


Gln Asp Lys Pro Met Pro Arg Ala Leu Arg Met Pro Asn Tyr Lys Lys 
    370                 375                 380                 


Lys Ala Thr 
385         


<210>  2562
<211>  2201
<212>  PRT
<213>  Homo sapiens

<400>  2562

Met Gly Ala Met Thr Gln Leu Leu Ala Gly Val Phe Leu Ala Phe Leu 
1               5                   10                  15      


Ala Leu Ala Thr Glu Gly Gly Val Leu Lys Lys Val Ile Arg His Lys 
            20                  25                  30          


Arg Gln Ser Gly Val Asn Ala Thr Leu Pro Glu Glu Asn Gln Pro Val 
        35                  40                  45              


Val Phe Asn His Val Tyr Asn Ile Lys Leu Pro Val Gly Ser Gln Cys 
    50                  55                  60                  


Ser Val Asp Leu Glu Ser Ala Ser Gly Glu Lys Asp Leu Ala Pro Pro 
65                  70                  75                  80  


Ser Glu Pro Ser Glu Ser Phe Gln Glu His Thr Val Asp Gly Glu Asn 
                85                  90                  95      


Gln Ile Val Phe Thr His Arg Ile Asn Ile Pro Arg Arg Ala Cys Gly 
            100                 105                 110         


Cys Ala Ala Ala Pro Asp Val Lys Glu Leu Leu Ser Arg Leu Glu Glu 
        115                 120                 125             


Leu Glu Asn Leu Val Ser Ser Leu Arg Glu Gln Cys Thr Ala Gly Ala 
    130                 135                 140                 


Gly Cys Cys Leu Gln Pro Ala Thr Gly Arg Leu Asp Thr Arg Pro Phe 
145                 150                 155                 160 


Cys Ser Gly Arg Gly Asn Phe Ser Thr Glu Gly Cys Gly Cys Val Cys 
                165                 170                 175     


Glu Pro Gly Trp Lys Gly Pro Asn Cys Ser Glu Pro Glu Cys Pro Gly 
            180                 185                 190         


Asn Cys His Leu Arg Gly Arg Cys Ile Asp Gly Gln Cys Ile Cys Asp 
        195                 200                 205             


Asp Gly Phe Thr Gly Glu Asp Cys Ser Gln Leu Ala Cys Pro Ser Asp 
    210                 215                 220                 


Cys Asn Asp Gln Gly Lys Cys Val Asn Gly Val Cys Ile Cys Phe Glu 
225                 230                 235                 240 


Gly Tyr Ala Gly Ala Asp Cys Ser Arg Glu Ile Cys Pro Val Pro Cys 
                245                 250                 255     


Ser Glu Glu His Gly Thr Cys Val Asp Gly Leu Cys Val Cys His Asp 
            260                 265                 270         


Gly Phe Ala Gly Asp Asp Cys Asn Lys Pro Leu Cys Leu Asn Asn Cys 
        275                 280                 285             


Tyr Asn Arg Gly Arg Cys Val Glu Asn Glu Cys Val Cys Asp Glu Gly 
    290                 295                 300                 


Phe Thr Gly Glu Asp Cys Ser Glu Leu Ile Cys Pro Asn Asp Cys Phe 
305                 310                 315                 320 


Asp Arg Gly Arg Cys Ile Asn Gly Thr Cys Tyr Cys Glu Glu Gly Phe 
                325                 330                 335     


Thr Gly Glu Asp Cys Gly Lys Pro Thr Cys Pro His Ala Cys His Thr 
            340                 345                 350         


Gln Gly Arg Cys Glu Glu Gly Gln Cys Val Cys Asp Glu Gly Phe Ala 
        355                 360                 365             


Gly Val Asp Cys Ser Glu Lys Arg Cys Pro Ala Asp Cys His Asn Arg 
    370                 375                 380                 


Gly Arg Cys Val Asp Gly Arg Cys Glu Cys Asp Asp Gly Phe Thr Gly 
385                 390                 395                 400 


Ala Asp Cys Gly Glu Leu Lys Cys Pro Asn Gly Cys Ser Gly His Gly 
                405                 410                 415     


Arg Cys Val Asn Gly Gln Cys Val Cys Asp Glu Gly Tyr Thr Gly Glu 
            420                 425                 430         


Asp Cys Ser Gln Leu Arg Cys Pro Asn Asp Cys His Ser Arg Gly Arg 
        435                 440                 445             


Cys Val Glu Gly Lys Cys Val Cys Glu Gln Gly Phe Lys Gly Tyr Asp 
    450                 455                 460                 


Cys Ser Asp Met Ser Cys Pro Asn Asp Cys His Gln His Gly Arg Cys 
465                 470                 475                 480 


Val Asn Gly Met Cys Val Cys Asp Asp Gly Tyr Thr Gly Glu Asp Cys 
                485                 490                 495     


Arg Asp Arg Gln Cys Pro Arg Asp Cys Ser Asn Arg Gly Leu Cys Val 
            500                 505                 510         


Asp Gly Gln Cys Val Cys Glu Asp Gly Phe Thr Gly Pro Asp Cys Ala 
        515                 520                 525             


Glu Leu Ser Cys Pro Asn Asp Cys His Gly Gln Gly Arg Cys Val Asn 
    530                 535                 540                 


Gly Gln Cys Val Cys His Glu Gly Phe Met Gly Lys Asp Cys Lys Glu 
545                 550                 555                 560 


Gln Arg Cys Pro Ser Asp Cys His Gly Gln Gly Arg Cys Val Asp Gly 
                565                 570                 575     


Gln Cys Ile Cys His Glu Gly Phe Thr Gly Leu Asp Cys Gly Gln His 
            580                 585                 590         


Ser Cys Pro Ser Asp Cys Asn Asn Leu Gly Gln Cys Val Ser Gly Arg 
        595                 600                 605             


Cys Ile Cys Asn Glu Gly Tyr Ser Gly Glu Asp Cys Ser Glu Val Ser 
    610                 615                 620                 


Pro Pro Lys Asp Leu Val Val Thr Glu Val Thr Glu Glu Thr Val Asn 
625                 630                 635                 640 


Leu Ala Trp Asp Asn Glu Met Arg Val Thr Glu Tyr Leu Val Val Tyr 
                645                 650                 655     


Thr Pro Thr His Glu Gly Gly Leu Glu Met Gln Phe Arg Val Pro Gly 
            660                 665                 670         


Asp Gln Thr Ser Thr Ile Ile Gln Glu Leu Glu Pro Gly Val Glu Tyr 
        675                 680                 685             


Phe Ile Arg Val Phe Ala Ile Leu Glu Asn Lys Lys Ser Ile Pro Val 
    690                 695                 700                 


Ser Ala Arg Val Ala Thr Tyr Leu Pro Ala Pro Glu Gly Leu Lys Phe 
705                 710                 715                 720 


Lys Ser Ile Lys Glu Thr Ser Val Glu Val Glu Trp Asp Pro Leu Asp 
                725                 730                 735     


Ile Ala Phe Glu Thr Trp Glu Ile Ile Phe Arg Asn Met Asn Lys Glu 
            740                 745                 750         


Asp Glu Gly Glu Ile Thr Lys Ser Leu Arg Arg Pro Glu Thr Ser Tyr 
        755                 760                 765             


Arg Gln Thr Gly Leu Ala Pro Gly Gln Glu Tyr Glu Ile Ser Leu His 
    770                 775                 780                 


Ile Val Lys Asn Asn Thr Arg Gly Pro Gly Leu Lys Arg Val Thr Thr 
785                 790                 795                 800 


Thr Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp 
                805                 810                 815     


Thr Thr Ala Leu Ile Thr Trp Phe Lys Pro Leu Ala Glu Ile Asp Gly 
            820                 825                 830         


Ile Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr 
        835                 840                 845             


Ile Asp Leu Thr Glu Asp Glu Asn Gln Tyr Ser Ile Gly Asn Leu Lys 
    850                 855                 860                 


Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Arg Arg Gly Asp Met 
865                 870                 875                 880 


Ser Ser Asn Pro Ala Lys Glu Thr Phe Thr Thr Gly Leu Asp Ala Pro 
                885                 890                 895     


Arg Asn Leu Arg Arg Val Ser Gln Thr Asp Asn Ser Ile Thr Leu Glu 
            900                 905                 910         


Trp Arg Asn Gly Lys Ala Ala Ile Asp Ser Tyr Arg Ile Lys Tyr Ala 
        915                 920                 925             


Pro Ile Ser Gly Gly Asp His Ala Glu Val Asp Val Pro Lys Ser Gln 
    930                 935                 940                 


Gln Ala Thr Thr Lys Thr Thr Leu Thr Gly Leu Arg Pro Gly Thr Glu 
945                 950                 955                 960 


Tyr Gly Ile Gly Val Ser Ala Val Lys Glu Asp Lys Glu Ser Asn Pro 
                965                 970                 975     


Ala Thr Ile Asn Ala Ala Thr Glu Leu Asp Thr Pro Lys Asp Leu Gln 
            980                 985                 990         


Val Ser Glu Thr Ala Glu Thr Ser  Leu Thr Leu Leu Trp  Lys Thr Pro 
        995                 1000                 1005             


Leu Ala  Lys Phe Asp Arg Tyr  Arg Leu Asn Tyr Ser  Leu Pro Thr 
    1010                 1015                 1020             


Gly Gln  Trp Val Gly Val Gln  Leu Pro Arg Asn Thr  Thr Ser Tyr 
    1025                 1030                 1035             


Val Leu  Arg Gly Leu Glu Pro  Gly Gln Glu Tyr Asn  Val Leu Leu 
    1040                 1045                 1050             


Thr Ala  Glu Lys Gly Arg His  Lys Ser Lys Pro Ala  Arg Val Lys 
    1055                 1060                 1065             


Ala Ser  Thr Glu Gln Ala Pro  Glu Leu Glu Asn Leu  Thr Val Thr 
    1070                 1075                 1080             


Glu Val  Gly Trp Asp Gly Leu  Arg Leu Asn Trp Thr  Ala Ala Asp 
    1085                 1090                 1095             


Gln Ala  Tyr Glu His Phe Ile  Ile Gln Val Gln Glu  Ala Asn Lys 
    1100                 1105                 1110             


Val Glu  Ala Ala Arg Asn Leu  Thr Val Pro Gly Ser  Leu Arg Ala 
    1115                 1120                 1125             


Val Asp  Ile Pro Gly Leu Lys  Ala Ala Thr Pro Tyr  Thr Val Ser 
    1130                 1135                 1140             


Ile Tyr  Gly Val Ile Gln Gly  Tyr Arg Thr Pro Val  Leu Ser Ala 
    1145                 1150                 1155             


Glu Ala  Ser Thr Gly Glu Thr  Pro Asn Leu Gly Glu  Val Val Val 
    1160                 1165                 1170             


Ala Glu  Val Gly Trp Asp Ala  Leu Lys Leu Asn Trp  Thr Ala Pro 
    1175                 1180                 1185             


Glu Gly  Ala Tyr Glu Tyr Phe  Phe Ile Gln Val Gln  Glu Ala Asp 
    1190                 1195                 1200             


Thr Val  Glu Ala Ala Gln Asn  Leu Thr Val Pro Gly  Gly Leu Arg 
    1205                 1210                 1215             


Ser Thr  Asp Leu Pro Gly Leu  Lys Ala Ala Thr His  Tyr Thr Ile 
    1220                 1225                 1230             


Thr Ile  Arg Gly Val Thr Gln  Asp Phe Ser Thr Thr  Pro Leu Ser 
    1235                 1240                 1245             


Val Glu  Val Leu Thr Glu Glu  Val Pro Asp Met Gly  Asn Leu Thr 
    1250                 1255                 1260             


Val Thr  Glu Val Ser Trp Asp  Ala Leu Arg Leu Asn  Trp Thr Thr 
    1265                 1270                 1275             


Pro Asp  Gly Thr Tyr Asp Gln  Phe Thr Ile Gln Val  Gln Glu Ala 
    1280                 1285                 1290             


Asp Gln  Val Glu Glu Ala His  Asn Leu Thr Val Pro  Gly Ser Leu 
    1295                 1300                 1305             


Arg Ser  Met Glu Ile Pro Gly  Leu Arg Ala Gly Thr  Pro Tyr Thr 
    1310                 1315                 1320             


Val Thr  Leu His Gly Glu Val  Arg Gly His Ser Thr  Arg Pro Leu 
    1325                 1330                 1335             


Ala Val  Glu Val Val Thr Glu  Asp Leu Pro Gln Leu  Gly Asp Leu 
    1340                 1345                 1350             


Ala Val  Ser Glu Val Gly Trp  Asp Gly Leu Arg Leu  Asn Trp Thr 
    1355                 1360                 1365             


Ala Ala  Asp Asn Ala Tyr Glu  His Phe Val Ile Gln  Val Gln Glu 
    1370                 1375                 1380             


Val Asn  Lys Val Glu Ala Ala  Gln Asn Leu Thr Leu  Pro Gly Ser 
    1385                 1390                 1395             


Leu Arg  Ala Val Asp Ile Pro  Gly Leu Glu Ala Ala  Thr Pro Tyr 
    1400                 1405                 1410             


Arg Val  Ser Ile Tyr Gly Val  Ile Arg Gly Tyr Arg  Thr Pro Val 
    1415                 1420                 1425             


Leu Ser  Ala Glu Ala Ser Thr  Ala Lys Glu Pro Glu  Ile Gly Asn 
    1430                 1435                 1440             


Leu Asn  Val Ser Asp Ile Thr  Pro Glu Ser Phe Asn  Leu Ser Trp 
    1445                 1450                 1455             


Met Ala  Thr Asp Gly Ile Phe  Glu Thr Phe Thr Ile  Glu Ile Ile 
    1460                 1465                 1470             


Asp Ser  Asn Arg Leu Leu Glu  Thr Val Glu Tyr Asn  Ile Ser Gly 
    1475                 1480                 1485             


Ala Glu  Arg Thr Ala His Ile  Ser Gly Leu Pro Pro  Ser Thr Asp 
    1490                 1495                 1500             


Phe Ile  Val Tyr Leu Ser Gly  Leu Ala Pro Ser Ile  Arg Thr Lys 
    1505                 1510                 1515             


Thr Ile  Ser Ala Thr Ala Thr  Thr Glu Ala Leu Pro  Leu Leu Glu 
    1520                 1525                 1530             


Asn Leu  Thr Ile Ser Asp Ile  Asn Pro Tyr Gly Phe  Thr Val Ser 
    1535                 1540                 1545             


Trp Met  Ala Ser Glu Asn Ala  Phe Asp Ser Phe Leu  Val Thr Val 
    1550                 1555                 1560             


Val Asp  Ser Gly Lys Leu Leu  Asp Pro Gln Glu Phe  Thr Leu Ser 
    1565                 1570                 1575             


Gly Thr  Gln Arg Lys Leu Glu  Leu Arg Gly Leu Ile  Thr Gly Ile 
    1580                 1585                 1590             


Gly Tyr  Glu Val Met Val Ser  Gly Phe Thr Gln Gly  His Gln Thr 
    1595                 1600                 1605             


Lys Pro  Leu Arg Ala Glu Ile  Val Thr Glu Ala Glu  Pro Glu Val 
    1610                 1615                 1620             


Asp Asn  Leu Leu Val Ser Asp  Ala Thr Pro Asp Gly  Phe Arg Leu 
    1625                 1630                 1635             


Ser Trp  Thr Ala Asp Glu Gly  Val Phe Asp Asn Phe  Val Leu Lys 
    1640                 1645                 1650             


Ile Arg  Asp Thr Lys Lys Gln  Ser Glu Pro Leu Glu  Ile Thr Leu 
    1655                 1660                 1665             


Leu Ala  Pro Glu Arg Thr Arg  Asp Ile Thr Gly Leu  Arg Glu Ala 
    1670                 1675                 1680             


Thr Glu  Tyr Glu Ile Glu Leu  Tyr Gly Ile Ser Lys  Gly Arg Arg 
    1685                 1690                 1695             


Ser Gln  Thr Val Ser Ala Ile  Ala Thr Thr Ala Met  Gly Ser Pro 
    1700                 1705                 1710             


Lys Glu  Val Ile Phe Ser Asp  Ile Thr Glu Asn Ser  Ala Thr Val 
    1715                 1720                 1725             


Ser Trp  Arg Ala Pro Thr Ala  Gln Val Glu Ser Phe  Arg Ile Thr 
    1730                 1735                 1740             


Tyr Val  Pro Ile Thr Gly Gly  Thr Pro Ser Met Val  Thr Val Asp 
    1745                 1750                 1755             


Gly Thr  Lys Thr Gln Thr Arg  Leu Val Lys Leu Ile  Pro Gly Val 
    1760                 1765                 1770             


Glu Tyr  Leu Val Ser Ile Ile  Ala Met Lys Gly Phe  Glu Glu Ser 
    1775                 1780                 1785             


Glu Pro  Val Ser Gly Ser Phe  Thr Thr Ala Leu Asp  Gly Pro Ser 
    1790                 1795                 1800             


Gly Leu  Val Thr Ala Asn Ile  Thr Asp Ser Glu Ala  Leu Ala Arg 
    1805                 1810                 1815             


Trp Gln  Pro Ala Ile Ala Thr  Val Asp Ser Tyr Val  Ile Ser Tyr 
    1820                 1825                 1830             


Thr Gly  Glu Lys Val Pro Glu  Ile Thr Arg Thr Val  Ser Gly Asn 
    1835                 1840                 1845             


Thr Val  Glu Tyr Ala Leu Thr  Asp Leu Glu Pro Ala  Thr Glu Tyr 
    1850                 1855                 1860             


Thr Leu  Arg Ile Phe Ala Glu  Lys Gly Pro Gln Lys  Ser Ser Thr 
    1865                 1870                 1875             


Ile Thr  Ala Lys Phe Thr Thr  Asp Leu Asp Ser Pro  Arg Asp Leu 
    1880                 1885                 1890             


Thr Ala  Thr Glu Val Gln Ser  Glu Thr Ala Leu Leu  Thr Trp Arg 
    1895                 1900                 1905             


Pro Pro  Arg Ala Ser Val Thr  Gly Tyr Leu Leu Val  Tyr Glu Ser 
    1910                 1915                 1920             


Val Asp  Gly Thr Val Lys Glu  Val Ile Val Gly Pro  Asp Thr Thr 
    1925                 1930                 1935             


Ser Tyr  Ser Leu Ala Asp Leu  Ser Pro Ser Thr His  Tyr Thr Ala 
    1940                 1945                 1950             


Lys Ile  Gln Ala Leu Asn Gly  Pro Leu Arg Ser Asn  Met Ile Gln 
    1955                 1960                 1965             


Thr Ile  Phe Thr Thr Ile Gly  Leu Leu Tyr Pro Phe  Pro Lys Asp 
    1970                 1975                 1980             


Cys Ser  Gln Ala Met Leu Asn  Gly Asp Thr Thr Ser  Gly Leu Tyr 
    1985                 1990                 1995             


Thr Ile  Tyr Leu Asn Gly Asp  Lys Ala Glu Ala Leu  Glu Val Phe 
    2000                 2005                 2010             


Cys Asp  Met Thr Ser Asp Gly  Gly Gly Trp Ile Val  Phe Leu Arg 
    2015                 2020                 2025             


Arg Lys  Asn Gly Arg Glu Asn  Phe Tyr Gln Asn Trp  Lys Ala Tyr 
    2030                 2035                 2040             


Ala Ala  Gly Phe Gly Asp Arg  Arg Glu Glu Phe Trp  Leu Gly Leu 
    2045                 2050                 2055             


Asp Asn  Leu Asn Lys Ile Thr  Ala Gln Gly Gln Tyr  Glu Leu Arg 
    2060                 2065                 2070             


Val Asp  Leu Arg Asp His Gly  Glu Thr Ala Phe Ala  Val Tyr Asp 
    2075                 2080                 2085             


Lys Phe  Ser Val Gly Asp Ala  Lys Thr Arg Tyr Lys  Leu Lys Val 
    2090                 2095                 2100             


Glu Gly  Tyr Ser Gly Thr Ala  Gly Asp Ser Met Ala  Tyr His Asn 
    2105                 2110                 2115             


Gly Arg  Ser Phe Ser Thr Phe  Asp Lys Asp Thr Asp  Ser Ala Ile 
    2120                 2125                 2130             


Thr Asn  Cys Ala Leu Ser Tyr  Lys Gly Ala Phe Trp  Tyr Arg Asn 
    2135                 2140                 2145             


Cys His  Arg Val Asn Leu Met  Gly Arg Tyr Gly Asp  Asn Asn His 
    2150                 2155                 2160             


Ser Gln  Gly Val Asn Trp Phe  His Trp Lys Gly His  Glu His Ser 
    2165                 2170                 2175             


Ile Gln  Phe Ala Glu Met Lys  Leu Arg Pro Ser Asn  Phe Arg Asn 
    2180                 2185                 2190             


Leu Glu  Gly Arg Arg Lys Arg  Ala 
    2195                 2200     


<210>  2563
<211>  547
<212>  PRT
<213>  Homo sapiens

<400>  2563

Met Ala Thr Met Val Pro Ser Val Leu Trp Pro Arg Ala Cys Trp Thr 
1               5                   10                  15      


Leu Leu Val Cys Cys Leu Leu Thr Pro Gly Val Gln Gly Gln Glu Phe 
            20                  25                  30          


Leu Leu Arg Val Glu Pro Gln Asn Pro Val Leu Ser Ala Gly Gly Ser 
        35                  40                  45              


Leu Phe Val Asn Cys Ser Thr Asp Cys Pro Ser Ser Glu Lys Ile Ala 
    50                  55                  60                  


Leu Glu Thr Ser Leu Ser Lys Glu Leu Val Ala Ser Gly Met Gly Trp 
65                  70                  75                  80  


Ala Ala Phe Asn Leu Ser Asn Val Thr Gly Asn Ser Arg Ile Leu Cys 
                85                  90                  95      


Ser Val Tyr Cys Asn Gly Ser Gln Ile Thr Gly Ser Ser Asn Ile Thr 
            100                 105                 110         


Val Tyr Arg Leu Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Pro Trp 
        115                 120                 125             


Gln Pro Val Gly Gln Asn Phe Thr Leu Arg Cys Gln Val Glu Asp Gly 
    130                 135                 140                 


Ser Pro Arg Thr Ser Leu Thr Val Val Leu Leu Arg Trp Glu Glu Glu 
145                 150                 155                 160 


Leu Ser Arg Gln Pro Ala Val Glu Glu Pro Ala Glu Val Thr Ala Thr 
                165                 170                 175     


Val Leu Ala Ser Arg Asp Asp His Gly Ala Pro Phe Ser Cys Arg Thr 
            180                 185                 190         


Glu Leu Asp Met Gln Pro Gln Gly Leu Gly Leu Phe Val Asn Thr Ser 
        195                 200                 205             


Ala Pro Arg Gln Leu Arg Thr Phe Val Leu Pro Val Thr Pro Pro Arg 
    210                 215                 220                 


Leu Val Ala Pro Arg Phe Leu Glu Val Glu Thr Ser Trp Pro Val Asp 
225                 230                 235                 240 


Cys Thr Leu Asp Gly Leu Phe Pro Ala Ser Glu Ala Gln Val Tyr Leu 
                245                 250                 255     


Ala Leu Gly Asp Gln Met Leu Asn Ala Thr Val Met Asn His Gly Asp 
            260                 265                 270         


Thr Leu Thr Ala Thr Ala Thr Ala Thr Ala Arg Ala Asp Gln Glu Gly 
        275                 280                 285             


Ala Arg Glu Ile Val Cys Asn Val Thr Leu Gly Gly Glu Arg Arg Glu 
    290                 295                 300                 


Ala Arg Glu Asn Leu Thr Val Phe Ser Phe Leu Gly Pro Ile Val Asn 
305                 310                 315                 320 


Leu Ser Glu Pro Thr Ala His Glu Gly Ser Thr Val Thr Val Ser Cys 
                325                 330                 335     


Met Ala Gly Ala Arg Val Gln Val Thr Leu Asp Gly Val Pro Ala Ala 
            340                 345                 350         


Ala Pro Gly Gln Pro Ala Gln Leu Gln Leu Asn Ala Thr Glu Ser Asp 
        355                 360                 365             


Asp Gly Arg Ser Phe Phe Cys Ser Ala Thr Leu Glu Val Asp Gly Glu 
    370                 375                 380                 


Phe Leu His Arg Asn Ser Ser Val Gln Leu Arg Val Leu Tyr Gly Pro 
385                 390                 395                 400 


Lys Ile Asp Arg Ala Thr Cys Pro Gln His Leu Lys Trp Lys Asp Lys 
                405                 410                 415     


Thr Arg His Val Leu Gln Cys Gln Ala Arg Gly Asn Pro Tyr Pro Glu 
            420                 425                 430         


Leu Arg Cys Leu Lys Glu Gly Ser Ser Arg Glu Val Pro Val Gly Ile 
        435                 440                 445             


Pro Phe Phe Val Asn Val Thr His Asn Gly Thr Tyr Gln Cys Gln Ala 
    450                 455                 460                 


Ser Ser Ser Arg Gly Lys Tyr Thr Leu Val Val Val Met Asp Ile Glu 
465                 470                 475                 480 


Ala Gly Ser Ser His Phe Val Pro Val Phe Val Ala Val Leu Leu Thr 
                485                 490                 495     


Leu Gly Val Val Thr Ile Val Leu Ala Leu Met Tyr Val Phe Arg Glu 
            500                 505                 510         


His Gln Arg Ser Gly Ser Tyr His Val Arg Glu Glu Ser Thr Tyr Leu 
        515                 520                 525             


Pro Leu Thr Ser Met Gln Pro Thr Glu Ala Met Gly Glu Glu Pro Ser 
    530                 535                 540                 


Arg Ala Glu 
545         


<210>  2564
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  2564

Met Thr Asn Lys Cys Leu Leu Gln Ile Ala Leu Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Met Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg 
            20                  25                  30          


Ser Ser Asn Phe Gln Cys Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg 
        35                  40                  45              


Leu Glu Tyr Cys Leu Lys Asp Arg Met Asn Phe Asp Ile Pro Glu Glu 
    50                  55                  60                  


Ile Lys Gln Leu Gln Gln Phe Gln Lys Glu Asp Ala Ala Leu Thr Ile 
65                  70                  75                  80  


Tyr Glu Met Leu Gln Asn Ile Phe Ala Ile Phe Arg Gln Asp Ser Ser 
                85                  90                  95      


Ser Thr Gly Trp Asn Glu Thr Ile Val Glu Asn Leu Leu Ala Asn Val 
            100                 105                 110         


Tyr His Gln Ile Asn His Leu Lys Thr Val Leu Glu Glu Lys Leu Glu 
        115                 120                 125             


Lys Glu Asp Phe Thr Arg Gly Lys Leu Met Ser Ser Leu His Leu Lys 
    130                 135                 140                 


Arg Tyr Tyr Gly Arg Ile Leu His Tyr Leu Lys Ala Lys Glu Tyr Ser 
145                 150                 155                 160 


His Cys Ala Trp Thr Ile Val Arg Val Glu Ile Leu Arg Asn Phe Tyr 
                165                 170                 175     


Phe Ile Asn Arg Leu Thr Gly Tyr Leu Arg Asn 
            180                 185         


<210>  2565
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  2565

Met Ser Pro Ala Arg Leu Arg Pro Arg Leu His Phe Cys Leu Val Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Val Pro Ala Ala Trp Gly Cys Gly Pro Gly Arg 
            20                  25                  30          


Val Val Gly Ser Arg Arg Arg Pro Pro Arg Lys Leu Val Pro Leu Ala 
        35                  40                  45              


Tyr Lys Gln Phe Ser Pro Asn Val Pro Glu Lys Thr Leu Gly Ala Ser 
    50                  55                  60                  


Gly Arg Tyr Glu Gly Lys Ile Ala Arg Ser Ser Glu Arg Phe Lys Glu 
65                  70                  75                  80  


Leu Thr Pro Asn Tyr Asn Pro Asp Ile Ile Phe Lys Asp Glu Glu Asn 
                85                  90                  95      


Thr Gly Ala Asp Arg Leu Met Thr Gln Arg Cys Lys Asp Arg Leu Asn 
            100                 105                 110         


Ser Leu Ala Ile Ser Val Met Asn Gln Trp Pro Gly Val Lys Leu Arg 
        115                 120                 125             


Val Thr Glu Gly Trp Asp Glu Asp Gly His His Ser Glu Glu Ser Leu 
    130                 135                 140                 


His Tyr Glu Gly Arg Ala Val Asp Ile Thr Thr Ser Asp Arg Asp Arg 
145                 150                 155                 160 


Asn Lys Tyr Gly Leu Leu Ala Arg Leu Ala Val Glu Ala Gly Phe Asp 
                165                 170                 175     


Trp Val Tyr Tyr Glu Ser Lys Ala His Val His Cys Ser Val Lys Ser 
            180                 185                 190         


Glu His Ser Ala Ala Ala Lys Thr Gly Gly Cys Phe Pro Ala Gly Ala 
        195                 200                 205             


Gln Val Arg Leu Glu Ser Gly Ala Arg Val Ala Leu Ser Ala Val Arg 
    210                 215                 220                 


Pro Gly Asp Arg Val Leu Ala Met Gly Glu Asp Gly Ser Pro Thr Phe 
225                 230                 235                 240 


Ser Asp Val Leu Ile Phe Leu Asp Arg Glu Pro His Arg Leu Arg Ala 
                245                 250                 255     


Phe Gln Val Ile Glu Thr Gln Asp Pro Pro Arg Arg Leu Ala Leu Thr 
            260                 265                 270         


Pro Ala His Leu Leu Phe Thr Ala Asp Asn His Thr Glu Pro Ala Ala 
        275                 280                 285             


Arg Phe Arg Ala Thr Phe Ala Ser His Val Gln Pro Gly Gln Tyr Val 
    290                 295                 300                 


Leu Val Ala Gly Val Pro Gly Leu Gln Pro Ala Arg Val Ala Ala Val 
305                 310                 315                 320 


Ser Thr His Val Ala Leu Gly Ala Tyr Ala Pro Leu Thr Lys His Gly 
                325                 330                 335     


Thr Leu Val Val Glu Asp Val Val Ala Ser Cys Phe Ala Ala Val Ala 
            340                 345                 350         


Asp His His Leu Ala Gln Leu Ala Phe Trp Pro Leu Arg Leu Phe His 
        355                 360                 365             


Ser Leu Ala Trp Gly Ser Trp Thr Pro Gly Glu Gly Val His Trp Tyr 
    370                 375                 380                 


Pro Gln Leu Leu Tyr Arg Leu Gly Arg Leu Leu Leu Glu Glu Gly Ser 
385                 390                 395                 400 


Phe His Pro Leu Gly Met Ser Gly Ala Gly Ser 
                405                 410     


<210>  2566
<211>  570
<212>  PRT
<213>  Homo sapiens

<400>  2566

Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu 
1               5                   10                  15      


Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met 
            20                  25                  30          


Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro 
        35                  40                  45              


Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala 
    50                  55                  60                  


Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu 
65                  70                  75                  80  


Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys 
                85                  90                  95      


Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro 
        115                 120                 125             


Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu 
    130                 135                 140                 


Pro Val His Lys Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys 
145                 150                 155                 160 


Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr 
                165                 170                 175     


Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro 
            180                 185                 190         


Glu Gly Met Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly 
        195                 200                 205             


Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His 
    210                 215                 220                 


Leu Thr Arg Thr Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala 
225                 230                 235                 240 


Val Pro Pro Val Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys 
                245                 250                 255     


Glu Pro Gly Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe 
            260                 265                 270         


Leu Met Asp Ser Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys 
        275                 280                 285             


Pro Asp Asp Ile Thr Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His 
    290                 295                 300                 


Ser Arg Thr Glu Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys 
305                 310                 315                 320 


Val Thr Ser Glu Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser 
                325                 330                 335     


Ala Lys Gly Glu Val Ala Lys Ala Ala Lys Val Lys Gln Lys Val Pro 
            340                 345                 350         


Ala Pro Arg Tyr Thr Val Glu Leu Ala Cys Gly Phe Gly Ala Thr Val 
        355                 360                 365             


Leu Leu Val Val Ile Leu Ile Val Val Tyr His Val Tyr Trp Leu Glu 
    370                 375                 380                 


Met Val Leu Phe Tyr Arg Ala His Phe Gly Thr Asp Glu Thr Ile Leu 
385                 390                 395                 400 


Asp Gly Lys Glu Tyr Asp Ile Tyr Val Ser Tyr Ala Arg Asn Ala Glu 
                405                 410                 415     


Glu Glu Glu Phe Val Leu Leu Thr Leu Arg Gly Val Leu Glu Asn Glu 
            420                 425                 430         


Phe Gly Tyr Lys Leu Cys Ile Phe Asp Arg Asp Ser Leu Pro Gly Gly 
        435                 440                 445             


Ile Val Thr Asp Glu Thr Leu Ser Phe Ile Gln Lys Ser Arg Arg Leu 
    450                 455                 460                 


Leu Val Val Leu Ser Pro Asn Tyr Val Leu Gln Gly Thr Gln Ala Leu 
465                 470                 475                 480 


Leu Glu Leu Lys Ala Gly Leu Glu Asn Met Ala Ser Arg Gly Asn Ile 
                485                 490                 495     


Asn Val Ile Leu Val Gln Tyr Lys Ala Val Lys Glu Thr Lys Val Lys 
            500                 505                 510         


Glu Leu Lys Arg Ala Lys Thr Val Leu Thr Val Ile Lys Trp Lys Gly 
        515                 520                 525             


Glu Lys Ser Lys Tyr Pro Gln Gly Arg Phe Trp Lys Gln Leu Gln Val 
    530                 535                 540                 


Ala Met Pro Val Lys Lys Ser Pro Arg Arg Ser Ser Ser Asp Glu Gln 
545                 550                 555                 560 


Gly Leu Ser Tyr Ser Ser Leu Lys Asn Val 
                565                 570 


<210>  2567
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  2567

Met Val Leu Leu Trp Leu Thr Leu Leu Leu Ile Ala Leu Pro Cys Leu 
1               5                   10                  15      


Leu Gln Thr Lys Glu Asp Pro Asn Pro Pro Ile Thr Asn Leu Arg Met 
            20                  25                  30          


Lys Ala Lys Ala Gln Gln Leu Thr Trp Asp Leu Asn Arg Asn Val Thr 
        35                  40                  45              


Asp Ile Glu Cys Val Lys Asp Ala Asp Tyr Ser Met Pro Ala Val Asn 
    50                  55                  60                  


Asn Ser Tyr Cys Gln Phe Gly Ala Ile Ser Leu Cys Glu Val Thr Asn 
65                  70                  75                  80  


Tyr Thr Val Arg Val Ala Asn Pro Pro Phe Ser Thr Trp Ile Leu Phe 
                85                  90                  95      


Pro Glu Asn Ser Gly Lys Pro Trp Ala Gly Ala Glu Asn Leu Thr Cys 
            100                 105                 110         


Trp Ile His Asp Val Asp Phe Leu Ser Cys Ser Trp Ala Val Gly Pro 
        115                 120                 125             


Gly Ala Pro Ala Asp Val Gln Tyr Asp Leu Tyr Leu Asn Val Ala Asn 
    130                 135                 140                 


Arg Arg Gln Gln Tyr Glu Cys Leu His Tyr Lys Thr Asp Ala Gln Gly 
145                 150                 155                 160 


Thr Arg Ile Gly Cys Arg Phe Asp Asp Ile Ser Arg Leu Ser Ser Gly 
                165                 170                 175     


Ser Gln Ser Ser His Ile Leu Val Arg Gly Arg Ser Ala Ala Phe Gly 
            180                 185                 190         


Ile Pro Cys Thr Asp Lys Phe Val Val Phe Ser Gln Ile Glu Ile Leu 
        195                 200                 205             


Thr Pro Pro Asn Met Thr Ala Lys Cys Asn Lys Thr His Ser Phe Met 
    210                 215                 220                 


His Trp Lys Met Arg Ser His Phe Asn Arg Lys Phe Arg Tyr Glu Leu 
225                 230                 235                 240 


Gln Ile Gln Lys Arg Met Gln Pro Val Ile Thr Glu Gln Val Arg Asp 
                245                 250                 255     


Arg Thr Ser Phe Gln Leu Leu Asn Pro Gly Thr Tyr Thr Val Gln Ile 
            260                 265                 270         


Arg Ala Arg Glu Arg Val Tyr Glu Phe Leu Ser Ala Trp Ser Thr Pro 
        275                 280                 285             


Gln Arg Phe Glu Cys Asp Gln Glu Glu Gly Ala Asn Thr Arg Ala Trp 
    290                 295                 300                 


Arg Thr Ser Leu Leu Ile Ala Leu Gly Thr Leu Leu Ala Leu Val Cys 
305                 310                 315                 320 


Val Phe Val Ile Cys Arg Arg Tyr Leu Val Met Gln Arg Leu Phe Pro 
                325                 330                 335     


Arg Ile Pro His Met Lys Asp Pro Ile Gly Asp Ser Phe Gln Asn Asp 
            340                 345                 350         


Lys Leu Val Val Trp Glu Ala Gly Lys Ala Gly Leu Glu Glu Cys Leu 
        355                 360                 365             


Val Thr Glu Val Gln Val Val Gln Lys Thr 
    370                 375             


<210>  2568
<211>  918
<212>  PRT
<213>  Homo sapiens

<400>  2568

Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile 
                325                 330                 335     


Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys 
            340                 345                 350         


Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val 
        355                 360                 365             


Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala 
    370                 375                 380                 


Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu 
385                 390                 395                 400 


Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile 
                405                 410                 415     


Pro Ala Cys Asp Phe Gln Ala Thr His Pro Val Met Asp Leu Lys Ala 
            420                 425                 430         


Phe Pro Lys Asp Asn Met Leu Trp Val Glu Trp Thr Thr Pro Arg Glu 
        435                 440                 445             


Ser Val Lys Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Asp Lys Ala 
    450                 455                 460                 


Pro Cys Ile Thr Asp Trp Gln Gln Glu Asp Gly Thr Val His Arg Thr 
465                 470                 475                 480 


Tyr Leu Arg Gly Asn Leu Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val 
                485                 490                 495     


Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala 
            500                 505                 510         


Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr Val Arg Thr Lys 
        515                 520                 525             


Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp Gln Leu Pro Val 
    530                 535                 540                 


Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr 
545                 550                 555                 560 


Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser Ser His Thr Glu 
                565                 570                 575     


Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr Met Val Arg Met 
            580                 585                 590         


Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe 
        595                 600                 605             


Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro 
    610                 615                 620                 


Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys 
625                 630                 635                 640 


Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro 
                645                 650                 655     


Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro 
            660                 665                 670         


Arg His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe 
        675                 680                 685             


Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys Lys Pro Phe 
    690                 695                 700                 


Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Asn 
705                 710                 715                 720 


Thr Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser 
                725                 730                 735     


Ser Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser Ser Gln Asn 
            740                 745                 750         


Thr Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg 
        755                 760                 765             


His Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu Ser Thr Gln 
    770                 775                 780                 


Pro Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln Leu Val Asp 
785                 790                 795                 800 


His Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys 
                805                 810                 815     


Gln Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile Ser His Phe Glu 
            820                 825                 830         


Arg Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp Phe Val Arg Leu 
        835                 840                 845             


Lys Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys Gly Ser Gly Gln 
    850                 855                 860                 


Met Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala Phe Gly Pro Gly 
865                 870                 875                 880 


Thr Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly Met Glu Ala Ala 
                885                 890                 895     


Thr Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln Thr Val Arg Gln 
            900                 905                 910         


Gly Gly Tyr Met Pro Gln 
        915             


<210>  2569
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  2569

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Ile Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Val Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro 
225                 230                 235                 240 


Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu 
                245                 250                 255     


Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val 
            260                 265                 270         


Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys 
        275                 280                 285             


Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu 
    290                 295                 300                 


Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val 
305                 310                 315                 320 


Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu 
                325                 330                 335     


Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu 
            340                 345                 350         


Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr 
        355                 360                 365             


Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser 
    370                 375                 380                 


Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val 
385                 390                 395                 400 


Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro 
                405                 410                 415     


Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala 
            420                 425                 430         


Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala 
        435                 440                 445             


Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    450                 455                 


<210>  2570
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  2570

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             


<210>  2571
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  2571

Met His Pro Leu Leu Asn Pro Leu Leu Leu Ala Leu Gly Leu Met Ala 
1               5                   10                  15      


Leu Leu Leu Thr Thr Val Ile Ala Leu Thr Cys Leu Gly Gly Phe Ala 
            20                  25                  30          


Ser Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu 
        35                  40                  45              


Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly 
    50                  55                  60                  


Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala 
65                  70                  75                  80  


Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr 
                85                  90                  95      


Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln 
            100                 105                 110         


Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala Gln Phe 
        115                 120                 125             


Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu Gly Gln 
    130                 135                 140                 


Phe Asn 
145     


<210>  2572
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  2572

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
        195                 200                 205             


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
    210                 215                 220                 


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
225                 230                 235                 240 


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
                245                 250                 255     


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
            260                 265         


<210>  2573
<211>  1181
<212>  PRT
<213>  Homo sapiens

<400>  2573

Met Gly Pro Glu Arg Thr Gly Ala Ala Pro Leu Pro Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Leu Ser Gln Gly Ile Leu Asn Cys Cys Leu Ala Tyr Asn Val 
            20                  25                  30          


Gly Leu Pro Glu Ala Lys Ile Phe Ser Gly Pro Ser Ser Glu Gln Phe 
        35                  40                  45              


Gly Tyr Ala Val Gln Gln Phe Ile Asn Pro Lys Gly Asn Trp Leu Leu 
    50                  55                  60                  


Val Gly Ser Pro Trp Ser Gly Phe Pro Glu Asn Arg Met Gly Asp Val 
65                  70                  75                  80  


Tyr Lys Cys Pro Val Asp Leu Ser Thr Ala Thr Cys Glu Lys Leu Asn 
                85                  90                  95      


Leu Gln Thr Ser Thr Ser Ile Pro Asn Val Thr Glu Met Lys Thr Asn 
            100                 105                 110         


Met Ser Leu Gly Leu Ile Leu Thr Arg Asn Met Gly Thr Gly Gly Phe 
        115                 120                 125             


Leu Thr Cys Gly Pro Leu Trp Ala Gln Gln Cys Gly Asn Gln Tyr Tyr 
    130                 135                 140                 


Thr Thr Gly Val Cys Ser Asp Ile Ser Pro Asp Phe Gln Leu Ser Ala 
145                 150                 155                 160 


Ser Phe Ser Pro Ala Thr Gln Pro Cys Pro Ser Leu Ile Asp Val Val 
                165                 170                 175     


Val Val Cys Asp Glu Ser Asn Ser Ile Tyr Pro Trp Asp Ala Val Lys 
            180                 185                 190         


Asn Phe Leu Glu Lys Phe Val Gln Gly Leu Asp Ile Gly Pro Thr Lys 
        195                 200                 205             


Thr Gln Val Gly Leu Ile Gln Tyr Ala Asn Asn Pro Arg Val Val Phe 
    210                 215                 220                 


Asn Leu Asn Thr Tyr Lys Thr Lys Glu Glu Met Ile Val Ala Thr Ser 
225                 230                 235                 240 


Gln Thr Ser Gln Tyr Gly Gly Asp Leu Thr Asn Thr Phe Gly Ala Ile 
                245                 250                 255     


Gln Tyr Ala Arg Lys Tyr Ala Tyr Ser Ala Ala Ser Gly Gly Arg Arg 
            260                 265                 270         


Ser Ala Thr Lys Val Met Val Val Val Thr Asp Gly Glu Ser His Asp 
        275                 280                 285             


Gly Ser Met Leu Lys Ala Val Ile Asp Gln Cys Asn His Asp Asn Ile 
    290                 295                 300                 


Leu Arg Phe Gly Ile Ala Val Leu Gly Tyr Leu Asn Arg Asn Ala Leu 
305                 310                 315                 320 


Asp Thr Lys Asn Leu Ile Lys Glu Ile Lys Ala Ile Ala Ser Ile Pro 
                325                 330                 335     


Thr Glu Arg Tyr Phe Phe Asn Val Ser Asp Glu Ala Ala Leu Leu Glu 
            340                 345                 350         


Lys Ala Gly Thr Leu Gly Glu Gln Ile Phe Ser Ile Glu Gly Thr Val 
        355                 360                 365             


Gln Gly Gly Asp Asn Phe Gln Met Glu Met Ser Gln Val Gly Phe Ser 
    370                 375                 380                 


Ala Asp Tyr Ser Ser Gln Asn Asp Ile Leu Met Leu Gly Ala Val Gly 
385                 390                 395                 400 


Ala Phe Gly Trp Ser Gly Thr Ile Val Gln Lys Thr Ser His Gly His 
                405                 410                 415     


Leu Ile Phe Pro Lys Gln Ala Phe Asp Gln Ile Leu Gln Asp Arg Asn 
            420                 425                 430         


His Ser Ser Tyr Leu Gly Tyr Ser Val Ala Ala Ile Ser Thr Gly Glu 
        435                 440                 445             


Ser Thr His Phe Val Ala Gly Ala Pro Arg Ala Asn Tyr Thr Gly Gln 
    450                 455                 460                 


Ile Val Leu Tyr Ser Val Asn Glu Asn Gly Asn Ile Thr Val Ile Gln 
465                 470                 475                 480 


Ala His Arg Gly Asp Gln Ile Gly Ser Tyr Phe Gly Ser Val Leu Cys 
                485                 490                 495     


Ser Val Asp Val Asp Lys Asp Thr Ile Thr Asp Val Leu Leu Val Gly 
            500                 505                 510         


Ala Pro Met Tyr Met Ser Asp Leu Lys Lys Glu Glu Gly Arg Val Tyr 
        515                 520                 525             


Leu Phe Thr Ile Lys Glu Gly Ile Leu Gly Gln His Gln Phe Leu Glu 
    530                 535                 540                 


Gly Pro Glu Gly Ile Glu Asn Thr Arg Phe Gly Ser Ala Ile Ala Ala 
545                 550                 555                 560 


Leu Ser Asp Ile Asn Met Asp Gly Phe Asn Asp Val Ile Val Gly Ser 
                565                 570                 575     


Pro Leu Glu Asn Gln Asn Ser Gly Ala Val Tyr Ile Tyr Asn Gly His 
            580                 585                 590         


Gln Gly Thr Ile Arg Thr Lys Tyr Ser Gln Lys Ile Leu Gly Ser Asp 
        595                 600                 605             


Gly Ala Phe Arg Ser His Leu Gln Tyr Phe Gly Arg Ser Leu Asp Gly 
    610                 615                 620                 


Tyr Gly Asp Leu Asn Gly Asp Ser Ile Thr Asp Val Ser Ile Gly Ala 
625                 630                 635                 640 


Phe Gly Gln Val Val Gln Leu Trp Ser Gln Ser Ile Ala Asp Val Ala 
                645                 650                 655     


Ile Glu Ala Ser Phe Thr Pro Glu Lys Ile Thr Leu Val Asn Lys Asn 
            660                 665                 670         


Ala Gln Ile Ile Leu Lys Leu Cys Phe Ser Ala Lys Phe Arg Pro Thr 
        675                 680                 685             


Lys Gln Asn Asn Gln Val Ala Ile Val Tyr Asn Ile Thr Leu Asp Ala 
    690                 695                 700                 


Asp Gly Phe Ser Ser Arg Val Thr Ser Arg Gly Leu Phe Lys Glu Asn 
705                 710                 715                 720 


Asn Glu Arg Cys Leu Gln Lys Asn Met Val Val Asn Gln Ala Gln Ser 
                725                 730                 735     


Cys Pro Glu His Ile Ile Tyr Ile Gln Glu Pro Ser Asp Val Val Asn 
            740                 745                 750         


Ser Leu Asp Leu Arg Val Asp Ile Ser Leu Glu Asn Pro Gly Thr Ser 
        755                 760                 765             


Pro Ala Leu Glu Ala Tyr Ser Glu Thr Ala Lys Val Phe Ser Ile Pro 
    770                 775                 780                 


Phe His Lys Asp Cys Gly Glu Asp Gly Leu Cys Ile Ser Asp Leu Val 
785                 790                 795                 800 


Leu Asp Val Arg Gln Ile Pro Ala Ala Gln Glu Gln Pro Phe Ile Val 
                805                 810                 815     


Ser Asn Gln Asn Lys Arg Leu Thr Phe Ser Val Thr Leu Lys Asn Lys 
            820                 825                 830         


Arg Glu Ser Ala Tyr Asn Thr Gly Ile Val Val Asp Phe Ser Glu Asn 
        835                 840                 845             


Leu Phe Phe Ala Ser Phe Ser Leu Pro Val Asp Gly Thr Glu Val Thr 
    850                 855                 860                 


Cys Gln Val Ala Ala Ser Gln Lys Ser Val Ala Cys Asp Val Gly Tyr 
865                 870                 875                 880 


Pro Ala Leu Lys Arg Glu Gln Gln Val Thr Phe Thr Ile Asn Phe Asp 
                885                 890                 895     


Phe Asn Leu Gln Asn Leu Gln Asn Gln Ala Ser Leu Ser Phe Gln Ala 
            900                 905                 910         


Leu Ser Glu Ser Gln Glu Glu Asn Lys Ala Asp Asn Leu Val Asn Leu 
        915                 920                 925             


Lys Ile Pro Leu Leu Tyr Asp Ala Glu Ile His Leu Thr Arg Ser Thr 
    930                 935                 940                 


Asn Ile Asn Phe Tyr Glu Ile Ser Ser Asp Gly Asn Val Pro Ser Ile 
945                 950                 955                 960 


Val His Ser Phe Glu Asp Val Gly Pro Lys Phe Ile Phe Ser Leu Lys 
                965                 970                 975     


Val Thr Thr Gly Ser Val Pro Val Ser Met Ala Thr Val Ile Ile His 
            980                 985                 990         


Ile Pro Gln Tyr Thr Lys Glu Lys  Asn Pro Leu Met Tyr  Leu Thr Gly 
        995                 1000                 1005             


Val Gln  Thr Asp Lys Ala Gly  Asp Ile Ser Cys Asn  Ala Asp Ile 
    1010                 1015                 1020             


Asn Pro  Leu Lys Ile Gly Gln  Thr Ser Ser Ser Val  Ser Phe Lys 
    1025                 1030                 1035             


Ser Glu  Asn Phe Arg His Thr  Lys Glu Leu Asn Cys  Arg Thr Ala 
    1040                 1045                 1050             


Ser Cys  Ser Asn Val Thr Cys  Trp Leu Lys Asp Val  His Met Lys 
    1055                 1060                 1065             


Gly Glu  Tyr Phe Val Asn Val  Thr Thr Arg Ile Trp  Asn Gly Thr 
    1070                 1075                 1080             


Phe Ala  Ser Ser Thr Phe Gln  Thr Val Gln Leu Thr  Ala Ala Ala 
    1085                 1090                 1095             


Glu Ile  Asn Thr Tyr Asn Pro  Glu Ile Tyr Val Ile  Glu Asp Asn 
    1100                 1105                 1110             


Thr Val  Thr Ile Pro Leu Met  Ile Met Lys Pro Asp  Glu Lys Ala 
    1115                 1120                 1125             


Glu Val  Pro Thr Gly Val Ile  Ile Gly Ser Ile Ile  Ala Gly Ile 
    1130                 1135                 1140             


Leu Leu  Leu Leu Ala Leu Val  Ala Ile Leu Trp Lys  Leu Gly Phe 
    1145                 1150                 1155             


Phe Lys  Arg Lys Tyr Glu Lys  Met Thr Lys Asn Pro  Asp Glu Ile 
    1160                 1165                 1170             


Asp Glu  Thr Thr Glu Leu Ser  Ser 
    1175                 1180     


<210>  2574
<211>  1051
<212>  PRT
<213>  Homo sapiens

<400>  2574

Met Gly Pro Gly Pro Ser Arg Ala Pro Arg Ala Pro Arg Leu Met Leu 
1               5                   10                  15      


Cys Ala Leu Ala Leu Met Val Ala Ala Gly Gly Cys Val Val Ser Ala 
            20                  25                  30          


Phe Asn Leu Asp Thr Arg Phe Leu Val Val Lys Glu Ala Gly Asn Pro 
        35                  40                  45              


Gly Ser Leu Phe Gly Tyr Ser Val Ala Leu His Arg Gln Thr Glu Arg 
    50                  55                  60                  


Gln Gln Arg Tyr Leu Leu Leu Ala Gly Ala Pro Arg Glu Leu Ala Val 
65                  70                  75                  80  


Pro Asp Gly Tyr Thr Asn Arg Thr Gly Ala Val Tyr Leu Cys Pro Leu 
                85                  90                  95      


Thr Ala His Lys Asp Asp Cys Glu Arg Met Asn Ile Thr Val Lys Asn 
            100                 105                 110         


Asp Pro Gly His His Ile Ile Glu Asp Met Trp Leu Gly Val Thr Val 
        115                 120                 125             


Ala Ser Gln Gly Pro Ala Gly Arg Val Leu Val Cys Ala His Arg Tyr 
    130                 135                 140                 


Thr Gln Val Leu Trp Ser Gly Ser Glu Asp Gln Arg Arg Met Val Gly 
145                 150                 155                 160 


Lys Cys Tyr Val Arg Gly Asn Asp Leu Glu Leu Asp Ser Ser Asp Asp 
                165                 170                 175     


Trp Gln Thr Tyr His Asn Glu Met Cys Asn Ser Asn Thr Asp Tyr Leu 
            180                 185                 190         


Glu Thr Gly Met Cys Gln Leu Gly Thr Ser Gly Gly Phe Thr Gln Asn 
        195                 200                 205             


Thr Val Tyr Phe Gly Ala Pro Gly Ala Tyr Asn Trp Lys Gly Asn Ser 
    210                 215                 220                 


Tyr Met Ile Gln Arg Lys Glu Trp Asp Leu Ser Glu Tyr Ser Tyr Lys 
225                 230                 235                 240 


Asp Pro Glu Asp Gln Gly Asn Leu Tyr Ile Gly Tyr Thr Met Gln Val 
                245                 250                 255     


Gly Ser Phe Ile Leu His Pro Lys Asn Ile Thr Ile Val Thr Gly Ala 
            260                 265                 270         


Pro Arg His Arg His Met Gly Ala Val Phe Leu Leu Ser Gln Glu Ala 
        275                 280                 285             


Gly Gly Asp Leu Arg Arg Arg Gln Val Leu Glu Gly Ser Gln Val Gly 
    290                 295                 300                 


Ala Tyr Phe Gly Ser Ala Ile Ala Leu Ala Asp Leu Asn Asn Asp Gly 
305                 310                 315                 320 


Trp Gln Asp Leu Leu Val Gly Ala Pro Tyr Tyr Phe Glu Arg Lys Glu 
                325                 330                 335     


Glu Val Gly Gly Ala Ile Tyr Val Phe Met Asn Gln Ala Gly Thr Ser 
            340                 345                 350         


Phe Pro Ala His Pro Ser Leu Leu Leu His Gly Pro Ser Gly Ser Ala 
        355                 360                 365             


Phe Gly Leu Ser Val Ala Ser Ile Gly Asp Ile Asn Gln Asp Gly Phe 
    370                 375                 380                 


Gln Asp Ile Ala Val Gly Ala Pro Phe Glu Gly Leu Gly Lys Val Tyr 
385                 390                 395                 400 


Ile Tyr His Ser Ser Ser Lys Gly Leu Leu Arg Gln Pro Gln Gln Val 
                405                 410                 415     


Ile His Gly Glu Lys Leu Gly Leu Pro Gly Leu Ala Thr Phe Gly Tyr 
            420                 425                 430         


Ser Leu Ser Gly Gln Met Asp Val Asp Glu Asn Phe Tyr Pro Asp Leu 
        435                 440                 445             


Leu Val Gly Ser Leu Ser Asp His Ile Val Leu Leu Arg Ala Arg Pro 
    450                 455                 460                 


Val Ile Asn Ile Val His Lys Thr Leu Val Pro Arg Pro Ala Val Leu 
465                 470                 475                 480 


Asp Pro Ala Leu Cys Thr Ala Thr Ser Cys Val Gln Val Glu Leu Cys 
                485                 490                 495     


Phe Ala Tyr Asn Gln Ser Ala Gly Asn Pro Asn Tyr Arg Arg Asn Ile 
            500                 505                 510         


Thr Leu Ala Tyr Thr Leu Glu Ala Asp Arg Asp Arg Arg Pro Pro Arg 
        515                 520                 525             


Leu Arg Phe Ala Gly Ser Glu Ser Ala Val Phe His Gly Phe Phe Ser 
    530                 535                 540                 


Met Pro Glu Met Arg Cys Gln Lys Leu Glu Leu Leu Leu Met Asp Asn 
545                 550                 555                 560 


Leu Arg Asp Lys Leu Arg Pro Ile Ile Ile Ser Met Asn Tyr Ser Leu 
                565                 570                 575     


Pro Leu Arg Met Pro Asp Arg Pro Arg Leu Gly Leu Arg Ser Leu Asp 
            580                 585                 590         


Ala Tyr Pro Ile Leu Asn Gln Ala Gln Ala Leu Glu Asn His Thr Glu 
        595                 600                 605             


Val Gln Phe Gln Lys Glu Cys Gly Pro Asp Asn Lys Cys Glu Ser Asn 
    610                 615                 620                 


Leu Gln Met Arg Ala Ala Phe Val Ser Glu Gln Gln Gln Lys Leu Ser 
625                 630                 635                 640 


Arg Leu Gln Tyr Ser Arg Asp Val Arg Lys Leu Leu Leu Ser Ile Asn 
                645                 650                 655     


Val Thr Asn Thr Arg Thr Ser Glu Arg Ser Gly Glu Asp Ala His Glu 
            660                 665                 670         


Ala Leu Leu Thr Leu Val Val Pro Pro Ala Leu Leu Leu Ser Ser Val 
        675                 680                 685             


Arg Pro Pro Gly Ala Cys Gln Ala Asn Glu Thr Ile Phe Cys Glu Leu 
    690                 695                 700                 


Gly Asn Pro Phe Lys Arg Asn Gln Arg Met Glu Leu Leu Ile Ala Phe 
705                 710                 715                 720 


Glu Val Ile Gly Val Thr Leu His Thr Arg Asp Leu Gln Val Gln Leu 
                725                 730                 735     


Gln Leu Ser Thr Ser Ser His Gln Asp Asn Leu Trp Pro Met Ile Leu 
            740                 745                 750         


Thr Leu Leu Val Asp Tyr Thr Leu Gln Thr Ser Leu Ser Met Val Asn 
        755                 760                 765             


His Arg Leu Gln Ser Phe Phe Gly Gly Thr Val Met Gly Glu Ser Gly 
    770                 775                 780                 


Met Lys Thr Val Glu Asp Val Gly Ser Pro Leu Lys Tyr Glu Phe Gln 
785                 790                 795                 800 


Val Gly Pro Met Gly Glu Gly Leu Val Gly Leu Gly Thr Leu Val Leu 
                805                 810                 815     


Gly Leu Glu Trp Pro Tyr Glu Val Ser Asn Gly Lys Trp Leu Leu Tyr 
            820                 825                 830         


Pro Thr Glu Ile Thr Val His Gly Asn Gly Ser Trp Pro Cys Arg Pro 
        835                 840                 845             


Pro Gly Asp Leu Ile Asn Pro Leu Asn Leu Thr Leu Ser Asp Pro Gly 
    850                 855                 860                 


Asp Arg Pro Ser Ser Pro Gln Arg Arg Arg Arg Gln Leu Asp Pro Gly 
865                 870                 875                 880 


Gly Gly Gln Gly Pro Pro Pro Val Thr Leu Ala Ala Ala Lys Lys Ala 
                885                 890                 895     


Lys Ser Glu Thr Val Leu Thr Cys Ala Thr Gly Arg Ala His Cys Val 
            900                 905                 910         


Trp Leu Glu Cys Pro Ile Pro Asp Ala Pro Val Val Thr Asn Val Thr 
        915                 920                 925             


Val Lys Ala Arg Val Trp Asn Ser Thr Phe Ile Glu Asp Tyr Arg Asp 
    930                 935                 940                 


Phe Asp Arg Val Arg Val Asn Gly Trp Ala Thr Leu Phe Leu Arg Thr 
945                 950                 955                 960 


Ser Ile Pro Thr Ile Asn Met Glu Asn Lys Thr Thr Trp Phe Ser Val 
                965                 970                 975     


Asp Ile Asp Ser Glu Leu Val Glu Glu Leu Pro Ala Glu Ile Glu Leu 
            980                 985                 990         


Trp Leu Val Leu Val Ala Val Gly  Ala Gly Leu Leu Leu  Leu Gly Leu 
        995                 1000                 1005             


Ile Ile  Leu Leu Leu Trp Lys  Cys Gly Phe Phe Lys  Arg Ala Arg 
    1010                 1015                 1020             


Thr Arg  Ala Leu Tyr Glu Ala  Lys Arg Gln Lys Ala  Glu Met Lys 
    1025                 1030                 1035             


Ser Gln  Pro Ser Glu Thr Glu  Arg Leu Thr Asp Asp  Tyr 
    1040                 1045                 1050     


<210>  2575
<211>  1049
<212>  PRT
<213>  Homo sapiens

<400>  2575

Met Gly Ser Arg Thr Pro Glu Ser Pro Leu His Ala Val Gln Leu Arg 
1               5                   10                  15      


Trp Gly Pro Arg Arg Arg Pro Pro Leu Leu Pro Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Pro Pro Pro Pro Arg Val Gly Gly Phe Asn Leu Asp Ala Glu Ala 
        35                  40                  45              


Pro Ala Val Leu Ser Gly Pro Pro Gly Ser Phe Phe Gly Phe Ser Val 
    50                  55                  60                  


Glu Phe Tyr Arg Pro Gly Thr Asp Gly Val Ser Val Leu Val Gly Ala 
65                  70                  75                  80  


Pro Lys Ala Asn Thr Ser Gln Pro Gly Val Leu Gln Gly Gly Ala Val 
                85                  90                  95      


Tyr Leu Cys Pro Trp Gly Ala Ser Pro Thr Gln Cys Thr Pro Ile Glu 
            100                 105                 110         


Phe Asp Ser Lys Gly Ser Arg Leu Leu Glu Ser Ser Leu Ser Ser Ser 
        115                 120                 125             


Glu Gly Glu Glu Pro Val Glu Tyr Lys Ser Leu Gln Trp Phe Gly Ala 
    130                 135                 140                 


Thr Val Arg Ala His Gly Ser Ser Ile Leu Ala Cys Ala Pro Leu Tyr 
145                 150                 155                 160 


Ser Trp Arg Thr Glu Lys Glu Pro Leu Ser Asp Pro Val Gly Thr Cys 
                165                 170                 175     


Tyr Leu Ser Thr Asp Asn Phe Thr Arg Ile Leu Glu Tyr Ala Pro Cys 
            180                 185                 190         


Arg Ser Asp Phe Ser Trp Ala Ala Gly Gln Gly Tyr Cys Gln Gly Gly 
        195                 200                 205             


Phe Ser Ala Glu Phe Thr Lys Thr Gly Arg Val Val Leu Gly Gly Pro 
    210                 215                 220                 


Gly Ser Tyr Phe Trp Gln Gly Gln Ile Leu Ser Ala Thr Gln Glu Gln 
225                 230                 235                 240 


Ile Ala Glu Ser Tyr Tyr Pro Glu Tyr Leu Ile Asn Leu Val Gln Gly 
                245                 250                 255     


Gln Leu Gln Thr Arg Gln Ala Ser Ser Ile Tyr Asp Asp Ser Tyr Leu 
            260                 265                 270         


Gly Tyr Ser Val Ala Val Gly Glu Phe Ser Gly Asp Asp Thr Glu Asp 
        275                 280                 285             


Phe Val Ala Gly Val Pro Lys Gly Asn Leu Thr Tyr Gly Tyr Val Thr 
    290                 295                 300                 


Ile Leu Asn Gly Ser Asp Ile Arg Ser Leu Tyr Asn Phe Ser Gly Glu 
305                 310                 315                 320 


Gln Met Ala Ser Tyr Phe Gly Tyr Ala Val Ala Ala Thr Asp Val Asn 
                325                 330                 335     


Gly Asp Gly Leu Asp Asp Leu Leu Val Gly Ala Pro Leu Leu Met Asp 
            340                 345                 350         


Arg Thr Pro Asp Gly Arg Pro Gln Glu Val Gly Arg Val Tyr Val Tyr 
        355                 360                 365             


Leu Gln His Pro Ala Gly Ile Glu Pro Thr Pro Thr Leu Thr Leu Thr 
    370                 375                 380                 


Gly His Asp Glu Phe Gly Arg Phe Gly Ser Ser Leu Thr Pro Leu Gly 
385                 390                 395                 400 


Asp Leu Asp Gln Asp Gly Tyr Asn Asp Val Ala Ile Gly Ala Pro Phe 
                405                 410                 415     


Gly Gly Glu Thr Gln Gln Gly Val Val Phe Val Phe Pro Gly Gly Pro 
            420                 425                 430         


Gly Gly Leu Gly Ser Lys Pro Ser Gln Val Leu Gln Pro Leu Trp Ala 
        435                 440                 445             


Ala Ser His Thr Pro Asp Phe Phe Gly Ser Ala Leu Arg Gly Gly Arg 
    450                 455                 460                 


Asp Leu Asp Gly Asn Gly Tyr Pro Asp Leu Ile Val Gly Ser Phe Gly 
465                 470                 475                 480 


Val Asp Lys Ala Val Val Tyr Arg Gly Arg Pro Ile Val Ser Ala Ser 
                485                 490                 495     


Ala Ser Leu Thr Ile Phe Pro Ala Met Phe Asn Pro Glu Glu Arg Ser 
            500                 505                 510         


Cys Ser Leu Glu Gly Asn Pro Val Ala Cys Ile Asn Leu Ser Phe Cys 
        515                 520                 525             


Leu Asn Ala Ser Gly Lys His Val Ala Asp Ser Ile Gly Phe Thr Val 
    530                 535                 540                 


Glu Leu Gln Leu Asp Trp Gln Lys Gln Lys Gly Gly Val Arg Arg Ala 
545                 550                 555                 560 


Leu Phe Leu Ala Ser Arg Gln Ala Thr Leu Thr Gln Thr Leu Leu Ile 
                565                 570                 575     


Gln Asn Gly Ala Arg Glu Asp Cys Arg Glu Met Lys Ile Tyr Leu Arg 
            580                 585                 590         


Asn Glu Ser Glu Phe Arg Asp Lys Leu Ser Pro Ile His Ile Ala Leu 
        595                 600                 605             


Asn Phe Ser Leu Asp Pro Gln Ala Pro Val Asp Ser His Gly Leu Arg 
    610                 615                 620                 


Pro Ala Leu His Tyr Gln Ser Lys Ser Arg Ile Glu Asp Lys Ala Gln 
625                 630                 635                 640 


Ile Leu Leu Asp Cys Gly Glu Asp Asn Ile Cys Val Pro Asp Leu Gln 
                645                 650                 655     


Leu Glu Val Phe Gly Glu Gln Asn His Val Tyr Leu Gly Asp Lys Asn 
            660                 665                 670         


Ala Leu Asn Leu Thr Phe His Ala Gln Asn Val Gly Glu Gly Gly Ala 
        675                 680                 685             


Tyr Glu Ala Glu Leu Arg Val Thr Ala Pro Pro Glu Ala Glu Tyr Ser 
    690                 695                 700                 


Gly Leu Val Arg His Pro Gly Asn Phe Ser Ser Leu Ser Cys Asp Tyr 
705                 710                 715                 720 


Phe Ala Val Asn Gln Ser Arg Leu Leu Val Cys Asp Leu Gly Asn Pro 
                725                 730                 735     


Met Lys Ala Gly Ala Ser Leu Trp Gly Gly Leu Arg Phe Thr Val Pro 
            740                 745                 750         


His Leu Arg Asp Thr Lys Lys Thr Ile Gln Phe Asp Phe Gln Ile Leu 
        755                 760                 765             


Ser Lys Asn Leu Asn Asn Ser Gln Ser Asp Val Val Ser Phe Arg Leu 
    770                 775                 780                 


Ser Val Glu Ala Gln Ala Gln Val Thr Leu Asn Gly Val Ser Lys Pro 
785                 790                 795                 800 


Glu Ala Val Leu Phe Pro Val Ser Asp Trp His Pro Arg Asp Gln Pro 
                805                 810                 815     


Gln Lys Glu Glu Asp Leu Gly Pro Ala Val His His Val Tyr Glu Leu 
            820                 825                 830         


Ile Asn Gln Gly Pro Ser Ser Ile Ser Gln Gly Val Leu Glu Leu Ser 
        835                 840                 845             


Cys Pro Gln Ala Leu Glu Gly Gln Gln Leu Leu Tyr Val Thr Arg Val 
    850                 855                 860                 


Thr Gly Leu Asn Cys Thr Thr Asn His Pro Ile Asn Pro Lys Gly Leu 
865                 870                 875                 880 


Glu Leu Asp Pro Glu Gly Ser Leu His His Gln Gln Lys Arg Glu Ala 
                885                 890                 895     


Pro Ser Arg Ser Ser Ala Ser Ser Gly Pro Gln Ile Leu Lys Cys Pro 
            900                 905                 910         


Glu Ala Glu Cys Phe Arg Leu Arg Cys Glu Leu Gly Pro Leu His Gln 
        915                 920                 925             


Gln Glu Ser Gln Ser Leu Gln Leu His Phe Arg Val Trp Ala Lys Thr 
    930                 935                 940                 


Phe Leu Gln Arg Glu His Gln Pro Phe Ser Leu Gln Cys Glu Ala Val 
945                 950                 955                 960 


Tyr Lys Ala Leu Lys Met Pro Tyr Arg Ile Leu Pro Arg Gln Leu Pro 
                965                 970                 975     


Gln Lys Glu Arg Gln Val Ala Thr Ala Val Gln Trp Thr Lys Ala Glu 
            980                 985                 990         


Gly Ser Tyr Gly Val Pro Leu Trp  Ile Ile Ile Leu Ala  Ile Leu Phe 
        995                 1000                 1005             


Gly Leu  Leu Leu Leu Gly Leu  Leu Ile Tyr Ile Leu  Tyr Lys Leu 
    1010                 1015                 1020             


Gly Phe  Phe Lys Arg Ser Leu  Pro Tyr Gly Thr Ala  Met Glu Lys 
    1025                 1030                 1035             


Ala Gln  Leu Lys Pro Pro Ala  Thr Ser Asp Ala 
    1040                 1045                 


<210>  2576
<211>  1137
<212>  PRT
<213>  Homo sapiens

<400>  2576

Met Ala Gly Ala Arg Ser Arg Asp Pro Trp Gly Ala Ser Gly Ile Cys 
1               5                   10                  15      


Tyr Leu Phe Gly Ser Leu Leu Val Glu Leu Leu Phe Ser Arg Ala Val 
            20                  25                  30          


Ala Phe Asn Leu Asp Val Met Gly Ala Leu Arg Lys Glu Gly Glu Pro 
        35                  40                  45              


Gly Ser Leu Phe Gly Phe Ser Val Ala Leu His Arg Gln Leu Gln Pro 
    50                  55                  60                  


Arg Pro Gln Ser Trp Leu Leu Val Gly Ala Pro Gln Ala Leu Ala Leu 
65                  70                  75                  80  


Pro Gly Gln Gln Ala Asn Arg Thr Gly Gly Leu Phe Ala Cys Pro Leu 
                85                  90                  95      


Ser Leu Glu Glu Thr Asp Cys Tyr Arg Val Asp Ile Asp Gln Gly Ala 
            100                 105                 110         


Asp Met Gln Lys Glu Ser Lys Glu Asn Gln Trp Leu Gly Val Ser Val 
        115                 120                 125             


Arg Ser Gln Gly Pro Gly Gly Lys Ile Val Thr Cys Ala His Arg Tyr 
    130                 135                 140                 


Glu Ala Arg Gln Arg Val Asp Gln Ile Leu Glu Thr Arg Asp Met Ile 
145                 150                 155                 160 


Gly Arg Cys Phe Val Leu Ser Gln Asp Leu Ala Ile Arg Asp Glu Leu 
                165                 170                 175     


Asp Gly Gly Glu Trp Lys Phe Cys Glu Gly Arg Pro Gln Gly His Glu 
            180                 185                 190         


Gln Phe Gly Phe Cys Gln Gln Gly Thr Ala Ala Ala Phe Ser Pro Asp 
        195                 200                 205             


Ser His Tyr Leu Leu Phe Gly Ala Pro Gly Thr Tyr Asn Trp Lys Gly 
    210                 215                 220                 


Leu Leu Phe Val Thr Asn Ile Asp Ser Ser Asp Pro Asp Gln Leu Val 
225                 230                 235                 240 


Tyr Lys Thr Leu Asp Pro Ala Asp Arg Leu Pro Gly Pro Ala Gly Asp 
                245                 250                 255     


Leu Ala Leu Asn Ser Tyr Leu Gly Phe Ser Ile Asp Ser Gly Lys Gly 
            260                 265                 270         


Leu Val Arg Ala Glu Glu Leu Ser Phe Val Ala Gly Ala Pro Arg Ala 
        275                 280                 285             


Asn His Lys Gly Ala Val Val Ile Leu Arg Lys Asp Ser Ala Ser Arg 
    290                 295                 300                 


Leu Val Pro Glu Val Met Leu Ser Gly Glu Arg Leu Thr Ser Gly Phe 
305                 310                 315                 320 


Gly Tyr Ser Leu Ala Val Ala Asp Leu Asn Ser Asp Gly Trp Pro Asp 
                325                 330                 335     


Leu Ile Val Gly Ala Pro Tyr Phe Phe Glu Arg Gln Glu Glu Leu Gly 
            340                 345                 350         


Gly Ala Val Tyr Val Tyr Leu Asn Gln Gly Gly His Trp Ala Gly Ile 
        355                 360                 365             


Ser Pro Leu Arg Leu Cys Gly Ser Pro Asp Ser Met Phe Gly Ile Ser 
    370                 375                 380                 


Leu Ala Val Leu Gly Asp Leu Asn Gln Asp Gly Phe Pro Asp Ile Ala 
385                 390                 395                 400 


Val Gly Ala Pro Phe Asp Gly Asp Gly Lys Val Phe Ile Tyr His Gly 
                405                 410                 415     


Ser Ser Leu Gly Val Val Ala Lys Pro Ser Gln Val Leu Glu Gly Glu 
            420                 425                 430         


Ala Val Gly Ile Lys Ser Phe Gly Tyr Ser Leu Ser Gly Ser Leu Asp 
        435                 440                 445             


Met Asp Gly Asn Gln Tyr Pro Asp Leu Leu Val Gly Ser Leu Ala Asp 
    450                 455                 460                 


Thr Ala Val Leu Phe Arg Ala Arg Pro Ile Leu His Val Ser His Glu 
465                 470                 475                 480 


Val Ser Ile Ala Pro Arg Ser Ile Asp Leu Glu Gln Pro Asn Cys Ala 
                485                 490                 495     


Gly Gly His Ser Val Cys Val Asp Leu Arg Val Cys Phe Ser Tyr Ile 
            500                 505                 510         


Ala Val Pro Ser Ser Tyr Ser Pro Thr Val Ala Leu Asp Tyr Val Leu 
        515                 520                 525             


Asp Ala Asp Thr Asp Arg Arg Leu Arg Gly Gln Val Pro Arg Val Thr 
    530                 535                 540                 


Phe Leu Ser Arg Asn Leu Glu Glu Pro Lys His Gln Ala Ser Gly Thr 
545                 550                 555                 560 


Val Trp Leu Lys His Gln His Asp Arg Val Cys Gly Asp Ala Met Phe 
                565                 570                 575     


Gln Leu Gln Glu Asn Val Lys Asp Lys Leu Arg Ala Ile Val Val Thr 
            580                 585                 590         


Leu Ser Tyr Ser Leu Gln Thr Pro Arg Leu Arg Arg Gln Ala Pro Gly 
        595                 600                 605             


Gln Gly Leu Pro Pro Val Ala Pro Ile Leu Asn Ala His Gln Pro Ser 
    610                 615                 620                 


Thr Gln Arg Ala Glu Ile His Phe Leu Lys Gln Gly Cys Gly Glu Asp 
625                 630                 635                 640 


Lys Ile Cys Gln Ser Asn Leu Gln Leu Val Arg Ala Arg Phe Cys Thr 
                645                 650                 655     


Arg Val Ser Asp Thr Glu Phe Gln Pro Leu Pro Met Asp Val Asp Gly 
            660                 665                 670         


Thr Thr Ala Leu Phe Ala Leu Ser Gly Gln Pro Val Ile Gly Leu Glu 
        675                 680                 685             


Leu Met Val Thr Asn Leu Pro Ser Asp Pro Ala Gln Pro Gln Ala Asp 
    690                 695                 700                 


Gly Asp Asp Ala His Glu Ala Gln Leu Leu Val Met Leu Pro Asp Ser 
705                 710                 715                 720 


Leu His Tyr Ser Gly Val Arg Ala Leu Asp Pro Ala Glu Lys Pro Leu 
                725                 730                 735     


Cys Leu Ser Asn Glu Asn Ala Ser His Val Glu Cys Glu Leu Gly Asn 
            740                 745                 750         


Pro Met Lys Arg Gly Ala Gln Val Thr Phe Tyr Leu Ile Leu Ser Thr 
        755                 760                 765             


Ser Gly Ile Ser Ile Glu Thr Thr Glu Leu Glu Val Glu Leu Leu Leu 
    770                 775                 780                 


Ala Thr Ile Ser Glu Gln Glu Leu His Pro Val Ser Ala Arg Ala Arg 
785                 790                 795                 800 


Val Phe Ile Glu Leu Pro Leu Ser Ile Ala Gly Met Ala Ile Pro Gln 
                805                 810                 815     


Gln Leu Phe Phe Ser Gly Val Val Arg Gly Glu Arg Ala Met Gln Ser 
            820                 825                 830         


Glu Arg Asp Val Gly Ser Lys Val Lys Tyr Glu Val Thr Val Ser Asn 
        835                 840                 845             


Gln Gly Gln Ser Leu Arg Thr Leu Gly Ser Ala Phe Leu Asn Ile Met 
    850                 855                 860                 


Trp Pro His Glu Ile Ala Asn Gly Lys Trp Leu Leu Tyr Pro Met Gln 
865                 870                 875                 880 


Val Glu Leu Glu Gly Gly Gln Gly Pro Gly Gln Lys Gly Leu Cys Ser 
                885                 890                 895     


Pro Arg Pro Asn Ile Leu His Leu Asp Val Asp Ser Arg Asp Arg Arg 
            900                 905                 910         


Arg Arg Glu Leu Glu Pro Pro Glu Gln Gln Glu Pro Gly Glu Arg Gln 
        915                 920                 925             


Glu Pro Ser Met Ser Trp Trp Pro Val Ser Ser Ala Glu Lys Lys Lys 
    930                 935                 940                 


Asn Ile Thr Leu Asp Cys Ala Arg Gly Thr Ala Asn Cys Val Val Phe 
945                 950                 955                 960 


Ser Cys Pro Leu Tyr Ser Phe Asp Arg Ala Ala Val Leu His Val Trp 
                965                 970                 975     


Gly Arg Leu Trp Asn Ser Thr Phe Leu Glu Glu Tyr Ser Ala Val Lys 
            980                 985                 990         


Ser Leu Glu Val Ile Val Arg Ala  Asn Ile Thr Val Lys  Ser Ser Ile 
        995                 1000                 1005             


Lys Asn  Leu Met Leu Arg Asp  Ala Ser Thr Val Ile  Pro Val Met 
    1010                 1015                 1020             


Val Tyr  Leu Asp Pro Met Ala  Val Val Ala Glu Gly  Val Pro Trp 
    1025                 1030                 1035             


Trp Val  Ile Leu Leu Ala Val  Leu Ala Gly Leu Leu  Val Leu Ala 
    1040                 1045                 1050             


Leu Leu  Val Leu Leu Leu Trp  Lys Met Gly Phe Phe  Lys Arg Ala 
    1055                 1060                 1065             


Lys His  Pro Glu Ala Thr Val  Pro Gln Tyr His Ala  Val Lys Ile 
    1070                 1075                 1080             


Pro Arg  Glu Asp Arg Gln Gln  Phe Lys Glu Glu Lys  Thr Gly Thr 
    1085                 1090                 1095             


Ile Leu  Arg Asn Asn Trp Gly  Ser Pro Arg Arg Glu  Gly Pro Asp 
    1100                 1105                 1110             


Ala His  Pro Ile Leu Ala Ala  Asp Gly His Pro Glu  Leu Gly Pro 
    1115                 1120                 1125             


Asp Gly  His Pro Gly Pro Gly  Thr Ala 
    1130                 1135         


<210>  2577
<211>  1035
<212>  PRT
<213>  Homo sapiens

<400>  2577

Met Gly Gly Pro Ala Ala Pro Arg Gly Ala Gly Arg Leu Arg Ala Leu 
1               5                   10                  15      


Leu Leu Ala Leu Val Val Ala Gly Ile Pro Ala Gly Ala Tyr Asn Leu 
            20                  25                  30          


Asp Pro Gln Arg Pro Val His Phe Gln Gly Pro Ala Asp Ser Phe Phe 
        35                  40                  45              


Gly Tyr Ala Val Leu Glu His Phe His Asp Asn Thr Arg Trp Val Leu 
    50                  55                  60                  


Val Gly Ala Pro Lys Ala Asp Ser Lys Tyr Ser Pro Ser Val Lys Ser 
65                  70                  75                  80  


Pro Gly Ala Val Phe Lys Cys Arg Val His Thr Asn Pro Asp Arg Arg 
                85                  90                  95      


Cys Thr Glu Leu Asp Met Ala Arg Gly Lys Asn Arg Gly Thr Ser Cys 
            100                 105                 110         


Gly Lys Thr Cys Arg Glu Asp Arg Asp Asp Glu Trp Met Gly Val Ser 
        115                 120                 125             


Leu Ala Arg Gln Pro Lys Ala Asp Gly Arg Val Leu Ala Cys Ala His 
    130                 135                 140                 


Arg Trp Lys Asn Ile Tyr Tyr Glu Ala Asp His Ile Leu Pro His Gly 
145                 150                 155                 160 


Phe Cys Tyr Ile Ile Pro Ser Asn Leu Gln Ala Lys Gly Arg Thr Leu 
                165                 170                 175     


Ile Pro Cys Tyr Glu Glu Tyr Lys Lys Lys Tyr Gly Glu Glu His Gly 
            180                 185                 190         


Ser Cys Gln Ala Gly Ile Ala Gly Phe Phe Thr Glu Glu Leu Val Val 
        195                 200                 205             


Met Gly Ala Pro Gly Ser Phe Tyr Trp Ala Gly Thr Ile Lys Val Leu 
    210                 215                 220                 


Asn Leu Thr Asp Asn Thr Tyr Leu Lys Leu Asn Asp Glu Val Ile Met 
225                 230                 235                 240 


Asn Arg Arg Tyr Thr Tyr Leu Gly Tyr Ala Val Thr Ala Gly His Phe 
                245                 250                 255     


Ser His Pro Ser Thr Ile Asp Val Val Gly Gly Ala Pro Gln Asp Lys 
            260                 265                 270         


Gly Ile Gly Lys Val Tyr Ile Phe Arg Ala Asp Arg Arg Ser Gly Thr 
        275                 280                 285             


Leu Ile Lys Ile Phe Gln Ala Ser Gly Lys Lys Met Gly Ser Tyr Phe 
    290                 295                 300                 


Gly Ser Ser Leu Cys Ala Val Asp Leu Asn Gly Asp Gly Leu Ser Asp 
305                 310                 315                 320 


Leu Leu Val Gly Ala Pro Met Phe Ser Glu Ile Arg Asp Glu Gly Gln 
                325                 330                 335     


Val Thr Val Tyr Ile Asn Arg Gly Asn Gly Ala Leu Glu Glu Gln Leu 
            340                 345                 350         


Ala Leu Thr Gly Asp Gly Ala Tyr Asn Ala His Phe Gly Glu Ser Ile 
        355                 360                 365             


Ala Ser Leu Asp Asp Leu Asp Asn Asp Gly Phe Pro Asp Val Ala Ile 
    370                 375                 380                 


Gly Ala Pro Lys Glu Asp Asp Phe Ala Gly Ala Val Tyr Ile Tyr His 
385                 390                 395                 400 


Gly Asp Ala Gly Gly Ile Val Pro Gln Tyr Ser Met Lys Leu Ser Gly 
                405                 410                 415     


Gln Lys Ile Asn Pro Val Leu Arg Met Phe Gly Gln Ser Ile Ser Gly 
            420                 425                 430         


Gly Ile Asp Met Asp Gly Asn Gly Tyr Pro Asp Val Thr Val Gly Ala 
        435                 440                 445             


Phe Met Ser Asp Ser Val Val Leu Leu Arg Ala Arg Pro Val Ile Thr 
    450                 455                 460                 


Val Asp Val Ser Ile Phe Leu Pro Gly Ser Ile Asn Ile Thr Ala Pro 
465                 470                 475                 480 


Gln Cys His Asp Gly Gln Gln Pro Val Asn Cys Leu Asn Val Thr Thr 
                485                 490                 495     


Cys Phe Ser Phe His Gly Lys His Val Pro Gly Glu Ile Gly Leu Asn 
            500                 505                 510         


Tyr Val Leu Met Ala Asp Val Ala Lys Lys Glu Lys Gly Gln Met Pro 
        515                 520                 525             


Arg Val Tyr Phe Val Leu Leu Gly Glu Thr Met Gly Gln Val Thr Glu 
    530                 535                 540                 


Lys Leu Gln Leu Thr Tyr Met Glu Glu Thr Cys Arg His Tyr Val Ala 
545                 550                 555                 560 


His Val Lys Arg Arg Val Gln Asp Val Ile Ser Pro Ile Val Phe Glu 
                565                 570                 575     


Ala Ala Tyr Ser Leu Ser Glu His Val Thr Gly Glu Glu Glu Arg Glu 
            580                 585                 590         


Leu Pro Pro Leu Thr Pro Val Leu Arg Trp Lys Lys Gly Gln Lys Ile 
        595                 600                 605             


Ala Gln Lys Asn Gln Thr Val Phe Glu Arg Asn Cys Arg Ser Glu Asp 
    610                 615                 620                 


Cys Ala Ala Asp Leu Gln Leu Gln Gly Lys Leu Leu Leu Ser Ser Met 
625                 630                 635                 640 


Asp Glu Lys Thr Leu Tyr Leu Ala Leu Gly Ala Val Lys Asn Ile Ser 
                645                 650                 655     


Leu Asn Ile Ser Ile Ser Asn Leu Gly Asp Asp Ala Tyr Asp Ala Asn 
            660                 665                 670         


Val Ser Phe Asn Val Ser Arg Glu Leu Phe Phe Ile Asn Met Trp Gln 
        675                 680                 685             


Lys Glu Glu Met Gly Ile Ser Cys Glu Leu Leu Glu Ser Asp Phe Leu 
    690                 695                 700                 


Lys Cys Ser Val Gly Phe Pro Phe Met Arg Ser Lys Ser Lys Tyr Glu 
705                 710                 715                 720 


Phe Ser Val Ile Phe Asp Thr Ser His Leu Ser Gly Glu Glu Glu Val 
                725                 730                 735     


Leu Ser Phe Ile Val Thr Ala Gln Ser Gly Asn Thr Glu Arg Ser Glu 
            740                 745                 750         


Ser Leu His Asp Asn Thr Leu Val Leu Met Val Pro Leu Met His Glu 
        755                 760                 765             


Val Asp Thr Ser Ile Thr Gly Ile Met Ser Pro Thr Ser Phe Val Tyr 
    770                 775                 780                 


Gly Glu Ser Val Asp Ala Ala Asn Phe Ile Gln Leu Asp Asp Leu Glu 
785                 790                 795                 800 


Cys His Phe Gln Pro Ile Asn Ile Thr Leu Gln Val Tyr Asn Thr Gly 
                805                 810                 815     


Pro Ser Thr Leu Pro Gly Ser Ser Val Ser Ile Ser Phe Pro Asn Arg 
            820                 825                 830         


Leu Ser Ser Gly Gly Ala Glu Met Phe His Val Gln Glu Met Val Val 
        835                 840                 845             


Gly Gln Glu Lys Gly Asn Cys Ser Phe Gln Lys Asn Pro Thr Pro Cys 
    850                 855                 860                 


Ile Ile Pro Gln Glu Gln Glu Asn Ile Phe His Thr Ile Phe Ala Phe 
865                 870                 875                 880 


Phe Thr Lys Ser Gly Arg Lys Val Leu Asp Cys Glu Lys Pro Gly Ile 
                885                 890                 895     


Ser Cys Leu Thr Ala His Cys Asn Phe Ser Ala Leu Ala Lys Glu Glu 
            900                 905                 910         


Ser Arg Thr Ile Asp Ile Tyr Met Leu Leu Asn Thr Glu Ile Leu Lys 
        915                 920                 925             


Lys Asp Ser Ser Ser Val Ile Gln Phe Met Ser Arg Ala Lys Val Lys 
    930                 935                 940                 


Val Asp Pro Ala Leu Arg Val Val Glu Ile Ala His Gly Asn Pro Glu 
945                 950                 955                 960 


Glu Val Thr Val Val Phe Glu Ala Leu His Asn Leu Glu Pro Arg Gly 
                965                 970                 975     


Tyr Val Val Gly Trp Ile Ile Ala Ile Ser Leu Leu Val Gly Ile Leu 
            980                 985                 990         


Ile Phe Leu Leu Leu Ala Val Leu  Leu Trp Lys Met Gly  Phe Phe Arg 
        995                 1000                 1005             


Arg Arg  Tyr Lys Glu Ile Ile  Glu Ala Glu Lys Asn  Arg Lys Glu 
    1010                 1015                 1020             


Asn Glu  Asp Ser Trp Asp Trp  Val Gln Lys Asn Gln  
    1025                 1030                 1035 


<210>  2578
<211>  1179
<212>  PRT
<213>  Homo sapiens

<400>  2578

Met Trp Leu Phe His Thr Leu Leu Cys Ile Ala Ser Leu Ala Leu Leu 
1               5                   10                  15      


Ala Ala Phe Asn Val Asp Val Ala Arg Pro Trp Leu Thr Pro Lys Gly 
            20                  25                  30          


Gly Ala Pro Phe Val Leu Ser Ser Leu Leu His Gln Asp Pro Ser Thr 
        35                  40                  45              


Asn Gln Thr Trp Leu Leu Val Thr Ser Pro Arg Thr Lys Arg Thr Pro 
    50                  55                  60                  


Gly Pro Leu His Arg Cys Ser Leu Val Gln Asp Glu Ile Leu Cys His 
65                  70                  75                  80  


Pro Val Glu His Val Pro Ile Pro Lys Gly Arg His Arg Gly Val Thr 
                85                  90                  95      


Val Val Arg Ser His His Gly Val Leu Ile Cys Ile Gln Val Leu Val 
            100                 105                 110         


Arg Arg Pro His Ser Leu Ser Ser Glu Leu Thr Gly Thr Cys Ser Leu 
        115                 120                 125             


Leu Gly Pro Asp Leu Arg Pro Gln Ala Gln Ala Asn Phe Phe Asp Leu 
    130                 135                 140                 


Glu Asn Leu Leu Asp Pro Asp Ala Arg Val Asp Thr Gly Asp Cys Tyr 
145                 150                 155                 160 


Ser Asn Lys Glu Gly Gly Gly Glu Asp Asp Val Asn Thr Ala Arg Gln 
                165                 170                 175     


Arg Arg Ala Leu Glu Lys Glu Glu Glu Glu Asp Lys Glu Glu Glu Glu 
            180                 185                 190         


Asp Glu Glu Glu Glu Glu Ala Gly Thr Glu Ile Ala Ile Ile Leu Asp 
        195                 200                 205             


Gly Ser Gly Ser Ile Asp Pro Pro Asp Phe Gln Arg Ala Lys Asp Phe 
    210                 215                 220                 


Ile Ser Asn Met Met Arg Asn Phe Tyr Glu Lys Cys Phe Glu Cys Asn 
225                 230                 235                 240 


Phe Ala Leu Val Gln Tyr Gly Gly Val Ile Gln Thr Glu Phe Asp Leu 
                245                 250                 255     


Arg Asp Ser Gln Asp Val Met Ala Ser Leu Ala Arg Val Gln Asn Ile 
            260                 265                 270         


Thr Gln Val Gly Ser Val Thr Lys Thr Ala Ser Ala Met Gln His Val 
        275                 280                 285             


Leu Asp Ser Ile Phe Thr Ser Ser His Gly Ser Arg Arg Lys Ala Ser 
    290                 295                 300                 


Lys Val Met Val Val Leu Thr Asp Gly Gly Ile Phe Glu Asp Pro Leu 
305                 310                 315                 320 


Asn Leu Thr Thr Val Ile Asn Ser Pro Lys Met Gln Gly Val Glu Arg 
                325                 330                 335     


Phe Ala Ile Gly Val Gly Glu Glu Phe Lys Ser Ala Arg Thr Ala Arg 
            340                 345                 350         


Glu Leu Asn Leu Ile Ala Ser Asp Pro Asp Glu Thr His Ala Phe Lys 
        355                 360                 365             


Val Thr Asn Tyr Met Ala Leu Asp Gly Leu Leu Ser Lys Leu Arg Tyr 
    370                 375                 380                 


Asn Ile Ile Ser Met Glu Gly Thr Val Gly Asp Ala Leu His Tyr Gln 
385                 390                 395                 400 


Leu Ala Gln Ile Gly Phe Ser Ala Gln Ile Leu Asp Glu Arg Gln Val 
                405                 410                 415     


Leu Leu Gly Ala Val Gly Ala Phe Asp Trp Ser Gly Gly Ala Leu Leu 
            420                 425                 430         


Tyr Asp Thr Arg Ser Arg Arg Gly Arg Phe Leu Asn Gln Thr Ala Ala 
        435                 440                 445             


Ala Ala Ala Asp Ala Glu Ala Ala Gln Tyr Ser Tyr Leu Gly Tyr Ala 
    450                 455                 460                 


Val Ala Val Leu His Lys Thr Cys Ser Leu Ser Tyr Ile Ala Gly Ala 
465                 470                 475                 480 


Pro Arg Tyr Lys His His Gly Ala Val Phe Glu Leu Gln Lys Glu Gly 
                485                 490                 495     


Arg Glu Ala Ser Phe Leu Pro Val Leu Glu Gly Glu Gln Met Gly Ser 
            500                 505                 510         


Tyr Phe Gly Ser Glu Leu Cys Pro Val Asp Ile Asp Met Asp Gly Ser 
        515                 520                 525             


Thr Asp Phe Leu Leu Val Ala Ala Pro Phe Tyr His Val His Gly Glu 
    530                 535                 540                 


Glu Gly Arg Val Tyr Val Tyr Arg Leu Ser Glu Gln Asp Gly Ser Phe 
545                 550                 555                 560 


Ser Leu Ala Arg Ile Leu Ser Gly His Pro Gly Phe Thr Asn Ala Arg 
                565                 570                 575     


Phe Gly Phe Ala Met Ala Ala Met Gly Asp Leu Ser Gln Asp Lys Leu 
            580                 585                 590         


Thr Asp Val Ala Ile Gly Ala Pro Leu Glu Gly Phe Gly Ala Asp Asp 
        595                 600                 605             


Gly Ala Ser Phe Gly Ser Val Tyr Ile Tyr Asn Gly His Trp Asp Gly 
    610                 615                 620                 


Leu Ser Ala Ser Pro Ser Gln Arg Ile Arg Ala Ser Thr Val Ala Pro 
625                 630                 635                 640 


Gly Leu Gln Tyr Phe Gly Met Ser Met Ala Gly Gly Phe Asp Ile Ser 
                645                 650                 655     


Gly Asp Gly Leu Ala Asp Ile Thr Val Gly Thr Leu Gly Gln Ala Val 
            660                 665                 670         


Val Phe Arg Ser Arg Pro Val Val Arg Leu Lys Val Ser Met Ala Phe 
        675                 680                 685             


Thr Pro Ser Ala Leu Pro Ile Gly Phe Asn Gly Val Val Asn Val Arg 
    690                 695                 700                 


Leu Cys Phe Glu Ile Ser Ser Val Thr Thr Ala Ser Glu Ser Gly Leu 
705                 710                 715                 720 


Arg Glu Ala Leu Leu Asn Phe Thr Leu Asp Val Asp Val Gly Lys Gln 
                725                 730                 735     


Arg Arg Arg Leu Gln Cys Ser Asp Val Arg Ser Cys Leu Gly Cys Leu 
            740                 745                 750         


Arg Glu Trp Ser Ser Gly Ser Gln Leu Cys Glu Asp Leu Leu Leu Met 
        755                 760                 765             


Pro Thr Glu Gly Glu Leu Cys Glu Glu Asp Cys Phe Ser Asn Ala Ser 
    770                 775                 780                 


Val Lys Val Ser Tyr Gln Leu Gln Thr Pro Glu Gly Gln Thr Asp His 
785                 790                 795                 800 


Pro Gln Pro Ile Leu Asp Arg Tyr Thr Glu Pro Phe Ala Ile Phe Gln 
                805                 810                 815     


Leu Pro Tyr Glu Lys Ala Cys Lys Asn Lys Leu Phe Cys Val Ala Glu 
            820                 825                 830         


Leu Gln Leu Ala Thr Thr Val Ser Gln Gln Glu Leu Val Val Gly Leu 
        835                 840                 845             


Thr Lys Glu Leu Thr Leu Asn Ile Asn Leu Thr Asn Ser Gly Glu Asp 
    850                 855                 860                 


Ser Tyr Met Thr Ser Met Ala Leu Asn Tyr Pro Arg Asn Leu Gln Leu 
865                 870                 875                 880 


Lys Arg Met Gln Lys Pro Pro Ser Pro Asn Ile Gln Cys Asp Asp Pro 
                885                 890                 895     


Gln Pro Val Ala Ser Val Leu Ile Met Asn Cys Arg Ile Gly His Pro 
            900                 905                 910         


Val Leu Lys Arg Ser Ser Ala His Val Ser Val Val Trp Gln Leu Glu 
        915                 920                 925             


Glu Asn Ala Phe Pro Asn Arg Thr Ala Asp Ile Thr Val Thr Val Thr 
    930                 935                 940                 


Asn Ser Asn Glu Arg Arg Ser Leu Ala Asn Glu Thr His Thr Leu Gln 
945                 950                 955                 960 


Phe Arg His Gly Phe Val Ala Val Leu Ser Lys Pro Ser Ile Met Tyr 
                965                 970                 975     


Val Asn Thr Gly Gln Gly Leu Ser His His Lys Glu Phe Leu Phe His 
            980                 985                 990         


Val His Gly Glu Asn Leu Phe Gly  Ala Glu Tyr Gln Leu  Gln Ile Cys 
        995                 1000                 1005             


Val Pro  Thr Lys Leu Arg Gly  Leu Gln Val Val Ala  Val Lys Lys 
    1010                 1015                 1020             


Leu Thr  Arg Thr Gln Ala Ser  Thr Val Cys Thr Trp  Ser Gln Glu 
    1025                 1030                 1035             


Arg Ala  Cys Ala Tyr Ser Ser  Val Gln His Val Glu  Glu Trp His 
    1040                 1045                 1050             


Ser Val  Ser Cys Val Ile Ala  Ser Asp Lys Glu Asn  Val Thr Val 
    1055                 1060                 1065             


Ala Ala  Glu Ile Ser Trp Asp  His Ser Glu Glu Leu  Leu Lys Asp 
    1070                 1075                 1080             


Val Thr  Glu Leu Gln Ile Leu  Gly Glu Ile Ser Phe  Asn Lys Ser 
    1085                 1090                 1095             


Leu Tyr  Glu Gly Leu Asn Ala  Glu Asn His Arg Thr  Lys Ile Thr 
    1100                 1105                 1110             


Val Val  Phe Leu Lys Asp Glu  Lys Tyr His Ser Leu  Pro Ile Ile 
    1115                 1120                 1125             


Ile Lys  Gly Ser Val Gly Gly  Leu Leu Val Leu Ile  Val Ile Leu 
    1130                 1135                 1140             


Val Ile  Leu Phe Lys Cys Gly  Phe Phe Lys Arg Lys  Tyr Gln Gln 
    1145                 1150                 1155             


Leu Asn  Leu Glu Ser Ile Arg  Lys Ala Gln Leu Lys  Ser Glu Asn 
    1160                 1165                 1170             


Leu Leu  Glu Glu Glu Asn 
    1175                 


<210>  2579
<211>  1048
<212>  PRT
<213>  Homo sapiens

<400>  2579

Met Ala Phe Pro Pro Arg Arg Arg Leu Arg Leu Gly Pro Arg Gly Leu 
1               5                   10                  15      


Pro Leu Leu Leu Ser Gly Leu Leu Leu Pro Leu Cys Arg Ala Phe Asn 
            20                  25                  30          


Leu Asp Val Asp Ser Pro Ala Glu Tyr Ser Gly Pro Glu Gly Ser Tyr 
        35                  40                  45              


Phe Gly Phe Ala Val Asp Phe Phe Val Pro Ser Ala Ser Ser Arg Met 
    50                  55                  60                  


Phe Leu Leu Val Gly Ala Pro Lys Ala Asn Thr Thr Gln Pro Gly Ile 
65                  70                  75                  80  


Val Glu Gly Gly Gln Val Leu Lys Cys Asp Trp Ser Ser Thr Arg Arg 
                85                  90                  95      


Cys Gln Pro Ile Glu Phe Asp Ala Thr Gly Asn Arg Asp Tyr Ala Lys 
            100                 105                 110         


Asp Asp Pro Leu Glu Phe Lys Ser His Gln Trp Phe Gly Ala Ser Val 
        115                 120                 125             


Arg Ser Lys Gln Asp Lys Ile Leu Ala Cys Ala Pro Leu Tyr His Trp 
    130                 135                 140                 


Arg Thr Glu Met Lys Gln Glu Arg Glu Pro Val Gly Thr Cys Phe Leu 
145                 150                 155                 160 


Gln Asp Gly Thr Lys Thr Val Glu Tyr Ala Pro Cys Arg Ser Gln Asp 
                165                 170                 175     


Ile Asp Ala Asp Gly Gln Gly Phe Cys Gln Gly Gly Phe Ser Ile Asp 
            180                 185                 190         


Phe Thr Lys Ala Asp Arg Val Leu Leu Gly Gly Pro Gly Ser Phe Tyr 
        195                 200                 205             


Trp Gln Gly Gln Leu Ile Ser Asp Gln Val Ala Glu Ile Val Ser Lys 
    210                 215                 220                 


Tyr Asp Pro Asn Val Tyr Ser Ile Lys Tyr Asn Asn Gln Leu Ala Thr 
225                 230                 235                 240 


Arg Thr Ala Gln Ala Ile Phe Asp Asp Ser Tyr Leu Gly Tyr Ser Val 
                245                 250                 255     


Ala Val Gly Asp Phe Asn Gly Asp Gly Ile Asp Asp Phe Val Ser Gly 
            260                 265                 270         


Val Pro Arg Ala Ala Arg Thr Leu Gly Met Val Tyr Ile Tyr Asp Gly 
        275                 280                 285             


Lys Asn Met Ser Ser Leu Tyr Asn Phe Thr Gly Glu Gln Met Ala Ala 
    290                 295                 300                 


Tyr Phe Gly Phe Ser Val Ala Ala Thr Asp Ile Asn Gly Asp Asp Tyr 
305                 310                 315                 320 


Ala Asp Val Phe Ile Gly Ala Pro Leu Phe Met Asp Arg Gly Ser Asp 
                325                 330                 335     


Gly Lys Leu Gln Glu Val Gly Gln Val Ser Val Ser Leu Gln Arg Ala 
            340                 345                 350         


Ser Gly Asp Phe Gln Thr Thr Lys Leu Asn Gly Phe Glu Val Phe Ala 
        355                 360                 365             


Arg Phe Gly Ser Ala Ile Ala Pro Leu Gly Asp Leu Asp Gln Asp Gly 
    370                 375                 380                 


Phe Asn Asp Ile Ala Ile Ala Ala Pro Tyr Gly Gly Glu Asp Lys Lys 
385                 390                 395                 400 


Gly Ile Val Tyr Ile Phe Asn Gly Arg Ser Thr Gly Leu Asn Ala Val 
                405                 410                 415     


Pro Ser Gln Ile Leu Glu Gly Gln Trp Ala Ala Arg Ser Met Pro Pro 
            420                 425                 430         


Ser Phe Gly Tyr Ser Met Lys Gly Ala Thr Asp Ile Asp Lys Asn Gly 
        435                 440                 445             


Tyr Pro Asp Leu Ile Val Gly Ala Phe Gly Val Asp Arg Ala Ile Leu 
    450                 455                 460                 


Tyr Arg Ala Arg Pro Val Ile Thr Val Asn Ala Gly Leu Glu Val Tyr 
465                 470                 475                 480 


Pro Ser Ile Leu Asn Gln Asp Asn Lys Thr Cys Ser Leu Pro Gly Thr 
                485                 490                 495     


Ala Leu Lys Val Ser Cys Phe Asn Val Arg Phe Cys Leu Lys Ala Asp 
            500                 505                 510         


Gly Lys Gly Val Leu Pro Arg Lys Leu Asn Phe Gln Val Glu Leu Leu 
        515                 520                 525             


Leu Asp Lys Leu Lys Gln Lys Gly Ala Ile Arg Arg Ala Leu Phe Leu 
    530                 535                 540                 


Tyr Ser Arg Ser Pro Ser His Ser Lys Asn Met Thr Ile Ser Arg Gly 
545                 550                 555                 560 


Gly Leu Met Gln Cys Glu Glu Leu Ile Ala Tyr Leu Arg Asp Glu Ser 
                565                 570                 575     


Glu Phe Arg Asp Lys Leu Thr Pro Ile Thr Ile Phe Met Glu Tyr Arg 
            580                 585                 590         


Leu Asp Tyr Arg Thr Ala Ala Asp Thr Thr Gly Leu Gln Pro Ile Leu 
        595                 600                 605             


Asn Gln Phe Thr Pro Ala Asn Ile Ser Arg Gln Ala His Ile Leu Leu 
    610                 615                 620                 


Asp Cys Gly Glu Asp Asn Val Cys Lys Pro Lys Leu Glu Val Ser Val 
625                 630                 635                 640 


Asp Ser Asp Gln Lys Lys Ile Tyr Ile Gly Asp Asp Asn Pro Leu Thr 
                645                 650                 655     


Leu Ile Val Lys Ala Gln Asn Gln Gly Glu Gly Ala Tyr Glu Ala Glu 
            660                 665                 670         


Leu Ile Val Ser Ile Pro Leu Gln Ala Asp Phe Ile Gly Val Val Arg 
        675                 680                 685             


Asn Asn Glu Ala Leu Ala Arg Leu Ser Cys Ala Phe Lys Thr Glu Asn 
    690                 695                 700                 


Gln Thr Arg Gln Val Val Cys Asp Leu Gly Asn Pro Met Lys Ala Gly 
705                 710                 715                 720 


Thr Gln Leu Leu Ala Gly Leu Arg Phe Ser Val His Gln Gln Ser Glu 
                725                 730                 735     


Met Asp Thr Ser Val Lys Phe Asp Leu Gln Ile Gln Ser Ser Asn Leu 
            740                 745                 750         


Phe Asp Lys Val Ser Pro Val Val Ser His Lys Val Asp Leu Ala Val 
        755                 760                 765             


Leu Ala Ala Val Glu Ile Arg Gly Val Ser Ser Pro Asp His Ile Phe 
    770                 775                 780                 


Leu Pro Ile Pro Asn Trp Glu His Lys Glu Asn Pro Glu Thr Glu Glu 
785                 790                 795                 800 


Asp Val Gly Pro Val Val Gln His Ile Tyr Glu Leu Arg Asn Asn Gly 
                805                 810                 815     


Pro Ser Ser Phe Ser Lys Ala Met Leu His Leu Gln Trp Pro Tyr Lys 
            820                 825                 830         


Tyr Asn Asn Asn Thr Leu Leu Tyr Ile Leu His Tyr Asp Ile Asp Gly 
        835                 840                 845             


Pro Met Asn Cys Thr Ser Asp Met Glu Ile Asn Pro Leu Arg Ile Lys 
    850                 855                 860                 


Ile Ser Ser Leu Gln Thr Thr Glu Lys Asn Asp Thr Val Ala Gly Gln 
865                 870                 875                 880 


Gly Glu Arg Asp His Leu Ile Thr Lys Arg Asp Leu Ala Leu Ser Glu 
                885                 890                 895     


Gly Asp Ile His Thr Leu Gly Cys Gly Val Ala Gln Cys Leu Lys Ile 
            900                 905                 910         


Val Cys Gln Val Gly Arg Leu Asp Arg Gly Lys Ser Ala Ile Leu Tyr 
        915                 920                 925             


Val Lys Ser Leu Leu Trp Thr Glu Thr Phe Met Asn Lys Glu Asn Gln 
    930                 935                 940                 


Asn His Ser Tyr Ser Leu Lys Ser Ser Ala Ser Phe Asn Val Ile Glu 
945                 950                 955                 960 


Phe Pro Tyr Lys Asn Leu Pro Ile Glu Asp Ile Thr Asn Ser Thr Leu 
                965                 970                 975     


Val Thr Thr Asn Val Thr Trp Gly Ile Gln Pro Ala Pro Met Pro Val 
            980                 985                 990         


Pro Val Trp Val Ile Ile Leu Ala  Val Leu Ala Gly Leu  Leu Leu Leu 
        995                 1000                 1005             


Ala Val  Leu Val Phe Val Met  Tyr Arg Met Gly Phe  Phe Lys Arg 
    1010                 1015                 1020             


Val Arg  Pro Pro Gln Glu Glu  Gln Glu Arg Glu Gln  Leu Gln Pro 
    1025                 1030                 1035             


His Glu  Asn Gly Glu Gly Asn  Ser Glu Thr 
    1040                 1045             


<210>  2580
<211>  799
<212>  PRT
<213>  Homo sapiens

<400>  2580

Met Pro Arg Ala Pro Ala Pro Leu Tyr Ala Cys Leu Leu Gly Leu Cys 
1               5                   10                  15      


Ala Leu Leu Pro Arg Leu Ala Gly Leu Asn Ile Cys Thr Ser Gly Ser 
            20                  25                  30          


Ala Thr Ser Cys Glu Glu Cys Leu Leu Ile His Pro Lys Cys Ala Trp 
        35                  40                  45              


Cys Ser Lys Glu Asp Phe Gly Ser Pro Arg Ser Ile Thr Ser Arg Cys 
    50                  55                  60                  


Asp Leu Arg Ala Asn Leu Val Lys Asn Gly Cys Gly Gly Glu Ile Glu 
65                  70                  75                  80  


Ser Pro Ala Ser Ser Phe His Val Leu Arg Ser Leu Pro Leu Ser Ser 
                85                  90                  95      


Lys Gly Ser Gly Ser Ala Gly Trp Asp Val Ile Gln Met Thr Pro Gln 
            100                 105                 110         


Glu Ile Ala Val Asn Leu Arg Pro Gly Asp Lys Thr Thr Phe Gln Leu 
        115                 120                 125             


Gln Val Arg Gln Val Glu Asp Tyr Pro Val Asp Leu Tyr Tyr Leu Met 
    130                 135                 140                 


Asp Leu Ser Leu Ser Met Lys Asp Asp Leu Asp Asn Ile Arg Ser Leu 
145                 150                 155                 160 


Gly Thr Lys Leu Ala Glu Glu Met Arg Lys Leu Thr Ser Asn Phe Arg 
                165                 170                 175     


Leu Gly Phe Gly Ser Phe Val Asp Lys Asp Ile Ser Pro Phe Ser Tyr 
            180                 185                 190         


Thr Ala Pro Arg Tyr Gln Thr Asn Pro Cys Ile Gly Tyr Lys Leu Phe 
        195                 200                 205             


Pro Asn Cys Val Pro Ser Phe Gly Phe Arg His Leu Leu Pro Leu Thr 
    210                 215                 220                 


Asp Arg Val Asp Ser Phe Asn Glu Glu Val Arg Lys Gln Arg Val Ser 
225                 230                 235                 240 


Arg Asn Arg Asp Ala Pro Glu Gly Gly Phe Asp Ala Val Leu Gln Ala 
                245                 250                 255     


Ala Val Cys Lys Glu Lys Ile Gly Trp Arg Lys Asp Ala Leu His Leu 
            260                 265                 270         


Leu Val Phe Thr Thr Asp Asp Val Pro His Ile Ala Leu Asp Gly Lys 
        275                 280                 285             


Leu Gly Gly Leu Val Gln Pro His Asp Gly Gln Cys His Leu Asn Glu 
    290                 295                 300                 


Ala Asn Glu Tyr Thr Ala Ser Asn Gln Met Asp Tyr Pro Ser Leu Ala 
305                 310                 315                 320 


Leu Leu Gly Glu Lys Leu Ala Glu Asn Asn Ile Asn Leu Ile Phe Ala 
                325                 330                 335     


Val Thr Lys Asn His Tyr Met Leu Tyr Lys Asn Phe Thr Ala Leu Ile 
            340                 345                 350         


Pro Gly Thr Thr Val Glu Ile Leu Asp Gly Asp Ser Lys Asn Ile Ile 
        355                 360                 365             


Gln Leu Ile Ile Asn Ala Tyr Asn Ser Ile Arg Ser Lys Val Glu Leu 
    370                 375                 380                 


Ser Val Trp Asp Gln Pro Glu Asp Leu Asn Leu Phe Phe Thr Ala Thr 
385                 390                 395                 400 


Cys Gln Asp Gly Val Ser Tyr Pro Gly Gln Arg Lys Cys Glu Gly Leu 
                405                 410                 415     


Lys Ile Gly Asp Thr Ala Ser Phe Glu Val Ser Leu Glu Ala Arg Ser 
            420                 425                 430         


Cys Pro Ser Arg His Thr Glu His Val Phe Ala Leu Arg Pro Val Gly 
        435                 440                 445             


Phe Arg Asp Ser Leu Glu Val Gly Val Thr Tyr Asn Cys Thr Cys Gly 
    450                 455                 460                 


Cys Ser Val Gly Leu Glu Pro Asn Ser Ala Arg Cys Asn Gly Ser Gly 
465                 470                 475                 480 


Thr Tyr Val Cys Gly Leu Cys Glu Cys Ser Pro Gly Tyr Leu Gly Thr 
                485                 490                 495     


Arg Cys Glu Cys Gln Asp Gly Glu Asn Gln Ser Val Tyr Gln Asn Leu 
            500                 505                 510         


Cys Arg Glu Ala Glu Gly Lys Pro Leu Cys Ser Gly Arg Gly Asp Cys 
        515                 520                 525             


Ser Cys Asn Gln Cys Ser Cys Phe Glu Ser Glu Phe Gly Lys Ile Tyr 
    530                 535                 540                 


Gly Pro Phe Cys Glu Cys Asp Asn Phe Ser Cys Ala Arg Asn Lys Gly 
545                 550                 555                 560 


Val Leu Cys Ser Gly His Gly Glu Cys His Cys Gly Glu Cys Lys Cys 
                565                 570                 575     


His Ala Gly Tyr Ile Gly Asp Asn Cys Asn Cys Ser Thr Asp Ile Ser 
            580                 585                 590         


Thr Cys Arg Gly Arg Asp Gly Gln Ile Cys Ser Glu Arg Gly His Cys 
        595                 600                 605             


Leu Cys Gly Gln Cys Gln Cys Thr Glu Pro Gly Ala Phe Gly Glu Met 
    610                 615                 620                 


Cys Glu Lys Cys Pro Thr Cys Pro Asp Ala Cys Ser Thr Lys Arg Asp 
625                 630                 635                 640 


Cys Val Glu Cys Leu Leu Leu His Ser Gly Lys Pro Asp Asn Gln Thr 
                645                 650                 655     


Cys His Ser Leu Cys Arg Asp Glu Val Ile Thr Trp Val Asp Thr Ile 
            660                 665                 670         


Val Lys Asp Asp Gln Glu Ala Val Leu Cys Phe Tyr Lys Thr Ala Lys 
        675                 680                 685             


Asp Cys Val Met Met Phe Thr Tyr Val Glu Leu Pro Ser Gly Lys Ser 
    690                 695                 700                 


Asn Leu Thr Val Leu Arg Glu Pro Glu Cys Gly Asn Thr Pro Asn Ala 
705                 710                 715                 720 


Met Thr Ile Leu Leu Ala Val Val Gly Ser Ile Leu Leu Val Gly Leu 
                725                 730                 735     


Ala Leu Leu Ala Ile Trp Lys Leu Leu Val Thr Ile His Asp Arg Arg 
            740                 745                 750         


Glu Phe Ala Lys Phe Gln Ser Glu Arg Ser Arg Ala Arg Tyr Glu Met 
        755                 760                 765             


Ala Ser Asn Pro Leu Tyr Arg Lys Pro Ile Ser Thr His Thr Val Asp 
    770                 775                 780                 


Phe Thr Phe Asn Lys Phe Asn Lys Ser Tyr Asn Gly Thr Val Asp 
785                 790                 795                 


<210>  2581
<211>  769
<212>  PRT
<213>  Homo sapiens

<400>  2581

Met Cys Gly Ser Ala Leu Ala Phe Phe Thr Ala Ala Phe Val Cys Leu 
1               5                   10                  15      


Gln Asn Asp Arg Arg Gly Pro Ala Ser Phe Leu Trp Ala Ala Trp Val 
            20                  25                  30          


Phe Ser Leu Val Leu Gly Leu Gly Gln Gly Glu Asp Asn Arg Cys Ala 
        35                  40                  45              


Ser Ser Asn Ala Ala Ser Cys Ala Arg Cys Leu Ala Leu Gly Pro Glu 
    50                  55                  60                  


Cys Gly Trp Cys Val Gln Glu Asp Phe Ile Ser Gly Gly Ser Arg Ser 
65                  70                  75                  80  


Glu Arg Cys Asp Ile Val Ser Asn Leu Ile Ser Lys Gly Cys Ser Val 
                85                  90                  95      


Asp Ser Ile Glu Tyr Pro Ser Val His Val Ile Ile Pro Thr Glu Asn 
            100                 105                 110         


Glu Ile Asn Thr Gln Val Thr Pro Gly Glu Val Ser Ile Gln Leu Arg 
        115                 120                 125             


Pro Gly Ala Glu Ala Asn Phe Met Leu Lys Val His Pro Leu Lys Lys 
    130                 135                 140                 


Tyr Pro Val Asp Leu Tyr Tyr Leu Val Asp Val Ser Ala Ser Met His 
145                 150                 155                 160 


Asn Asn Ile Glu Lys Leu Asn Ser Val Gly Asn Asp Leu Ser Arg Lys 
                165                 170                 175     


Met Ala Phe Phe Ser Arg Asp Phe Arg Leu Gly Phe Gly Ser Tyr Val 
            180                 185                 190         


Asp Lys Thr Val Ser Pro Tyr Ile Ser Ile His Pro Glu Arg Ile His 
        195                 200                 205             


Asn Gln Cys Ser Asp Tyr Asn Leu Asp Cys Met Pro Pro His Gly Tyr 
    210                 215                 220                 


Ile His Val Leu Ser Leu Thr Glu Asn Ile Thr Glu Phe Glu Lys Ala 
225                 230                 235                 240 


Val His Arg Gln Lys Ile Ser Gly Asn Ile Asp Thr Pro Glu Gly Gly 
                245                 250                 255     


Phe Asp Ala Met Leu Gln Ala Ala Val Cys Glu Ser His Ile Gly Trp 
            260                 265                 270         


Arg Lys Glu Ala Lys Arg Leu Leu Leu Val Met Thr Asp Gln Thr Ser 
        275                 280                 285             


His Leu Ala Leu Asp Ser Lys Leu Ala Gly Ile Val Val Pro Asn Asp 
    290                 295                 300                 


Gly Asn Cys His Leu Lys Asn Asn Val Tyr Val Lys Ser Thr Thr Met 
305                 310                 315                 320 


Glu His Pro Ser Leu Gly Gln Leu Ser Glu Lys Leu Ile Asp Asn Asn 
                325                 330                 335     


Ile Asn Val Ile Phe Ala Val Gln Gly Lys Gln Phe His Trp Tyr Lys 
            340                 345                 350         


Asp Leu Leu Pro Leu Leu Pro Gly Thr Ile Ala Gly Glu Ile Glu Ser 
        355                 360                 365             


Lys Ala Ala Asn Leu Asn Asn Leu Val Val Glu Ala Tyr Gln Lys Leu 
    370                 375                 380                 


Ile Ser Glu Val Lys Val Gln Val Glu Asn Gln Val Gln Gly Ile Tyr 
385                 390                 395                 400 


Phe Asn Ile Thr Ala Ile Cys Pro Asp Gly Ser Arg Lys Pro Gly Met 
                405                 410                 415     


Glu Gly Cys Arg Asn Val Thr Ser Asn Asp Glu Val Leu Phe Asn Val 
            420                 425                 430         


Thr Val Thr Met Lys Lys Cys Asp Val Thr Gly Gly Lys Asn Tyr Ala 
        435                 440                 445             


Ile Ile Lys Pro Ile Gly Phe Asn Glu Thr Ala Lys Ile His Ile His 
    450                 455                 460                 


Arg Asn Cys Ser Cys Gln Cys Glu Asp Asn Arg Gly Pro Lys Gly Lys 
465                 470                 475                 480 


Cys Val Asp Glu Thr Phe Leu Asp Ser Lys Cys Phe Gln Cys Asp Glu 
                485                 490                 495     


Asn Lys Cys His Phe Asp Glu Asp Gln Phe Ser Ser Glu Ser Cys Lys 
            500                 505                 510         


Ser His Lys Asp Gln Pro Val Cys Ser Gly Arg Gly Val Cys Val Cys 
        515                 520                 525             


Gly Lys Cys Ser Cys His Lys Ile Lys Leu Gly Lys Val Tyr Gly Lys 
    530                 535                 540                 


Tyr Cys Glu Lys Asp Asp Phe Ser Cys Pro Tyr His His Gly Asn Leu 
545                 550                 555                 560 


Cys Ala Gly His Gly Glu Cys Glu Ala Gly Arg Cys Gln Cys Phe Ser 
                565                 570                 575     


Gly Trp Glu Gly Asp Arg Cys Gln Cys Pro Ser Ala Ala Ala Gln His 
            580                 585                 590         


Cys Val Asn Ser Lys Gly Gln Val Cys Ser Gly Arg Gly Thr Cys Val 
        595                 600                 605             


Cys Gly Arg Cys Glu Cys Thr Asp Pro Arg Ser Ile Gly Arg Phe Cys 
    610                 615                 620                 


Glu His Cys Pro Thr Cys Tyr Thr Ala Cys Lys Glu Asn Trp Asn Cys 
625                 630                 635                 640 


Met Gln Cys Leu His Pro His Asn Leu Ser Gln Ala Ile Leu Asp Gln 
                645                 650                 655     


Cys Lys Thr Ser Cys Ala Leu Met Glu Gln Gln His Tyr Val Asp Gln 
            660                 665                 670         


Thr Ser Glu Cys Phe Ser Ser Pro Ser Tyr Leu Arg Ile Phe Phe Ile 
        675                 680                 685             


Ile Phe Ile Val Thr Phe Leu Ile Gly Leu Leu Lys Val Leu Ile Ile 
    690                 695                 700                 


Arg Gln Val Ile Leu Gln Trp Asn Ser Asn Lys Ile Lys Ser Ser Ser 
705                 710                 715                 720 


Asp Tyr Arg Val Ser Ala Ser Lys Lys Asp Lys Leu Ile Leu Gln Ser 
                725                 730                 735     


Val Cys Thr Arg Ala Val Thr Tyr Arg Arg Glu Lys Pro Glu Glu Ile 
            740                 745                 750         


Lys Met Asp Ile Ser Lys Leu Asn Ala His Glu Thr Phe Arg Cys Asn 
        755                 760                 765             


Phe 
    


<210>  2582
<211>  911
<212>  PRT
<213>  Homo sapiens

<400>  2582

Met Asp Gly Ala Met Gly Pro Arg Gly Leu Leu Leu Cys Met Tyr Leu 
1               5                   10                  15      


Val Ser Leu Leu Ile Leu Gln Ala Met Pro Ala Leu Gly Ser Ala Thr 
            20                  25                  30          


Gly Arg Ser Lys Ser Ser Glu Lys Arg Gln Ala Val Asp Thr Ala Val 
        35                  40                  45              


Asp Gly Val Phe Ile Arg Ser Leu Lys Val Asn Cys Lys Val Thr Ser 
    50                  55                  60                  


Arg Phe Ala His Tyr Val Val Thr Ser Gln Val Val Asn Thr Ala Asn 
65                  70                  75                  80  


Glu Ala Arg Glu Val Ala Phe Asp Leu Glu Ile Pro Lys Thr Ala Phe 
                85                  90                  95      


Ile Ser Asp Phe Ala Val Thr Ala Asp Gly Asn Ala Phe Ile Gly Asp 
            100                 105                 110         


Ile Lys Asp Lys Val Thr Ala Trp Lys Gln Tyr Arg Lys Ala Ala Ile 
        115                 120                 125             


Ser Gly Glu Asn Ala Gly Leu Val Arg Ala Ser Gly Arg Thr Met Glu 
    130                 135                 140                 


Gln Phe Thr Ile His Leu Thr Val Asn Pro Gln Ser Lys Val Thr Phe 
145                 150                 155                 160 


Gln Leu Thr Tyr Glu Glu Val Leu Lys Arg Asn His Met Gln Tyr Glu 
                165                 170                 175     


Ile Val Ile Lys Val Lys Pro Lys Gln Leu Val His His Phe Glu Ile 
            180                 185                 190         


Asp Val Asp Ile Phe Glu Pro Gln Gly Ile Ser Lys Leu Asp Ala Gln 
        195                 200                 205             


Ala Ser Phe Leu Pro Lys Glu Leu Ala Ala Gln Thr Ile Lys Lys Ser 
    210                 215                 220                 


Phe Ser Gly Lys Lys Gly His Val Leu Phe Arg Pro Thr Val Ser Gln 
225                 230                 235                 240 


Gln Gln Ser Cys Pro Thr Cys Ser Thr Ser Leu Leu Asn Gly His Phe 
                245                 250                 255     


Lys Val Thr Tyr Asp Val Ser Arg Asp Lys Ile Cys Asp Leu Leu Val 
            260                 265                 270         


Ala Asn Asn His Phe Ala His Phe Phe Ala Pro Gln Asn Leu Thr Asn 
        275                 280                 285             


Met Asn Lys Asn Val Val Phe Val Ile Asp Ile Ser Gly Ser Met Arg 
    290                 295                 300                 


Gly Gln Lys Val Lys Gln Thr Lys Glu Ala Leu Leu Lys Ile Leu Gly 
305                 310                 315                 320 


Asp Met Gln Pro Gly Asp Tyr Phe Asp Leu Val Leu Phe Gly Thr Arg 
                325                 330                 335     


Val Gln Ser Trp Lys Gly Ser Leu Val Gln Ala Ser Glu Ala Asn Leu 
            340                 345                 350         


Gln Ala Ala Gln Asp Phe Val Arg Gly Phe Ser Leu Asp Glu Ala Thr 
        355                 360                 365             


Asn Leu Asn Gly Gly Leu Leu Arg Gly Ile Glu Ile Leu Asn Gln Val 
    370                 375                 380                 


Gln Glu Ser Leu Pro Glu Leu Ser Asn His Ala Ser Ile Leu Ile Met 
385                 390                 395                 400 


Leu Thr Asp Gly Asp Pro Thr Glu Gly Val Thr Asp Arg Ser Gln Ile 
                405                 410                 415     


Leu Lys Asn Val Arg Asn Ala Ile Arg Gly Arg Phe Pro Leu Tyr Asn 
            420                 425                 430         


Leu Gly Phe Gly His Asn Val Asp Phe Asn Phe Leu Glu Val Met Ser 
        435                 440                 445             


Met Glu Asn Asn Gly Arg Ala Gln Arg Ile Tyr Glu Asp His Asp Ala 
    450                 455                 460                 


Thr Gln Gln Leu Gln Gly Phe Tyr Ser Gln Val Ala Lys Pro Leu Leu 
465                 470                 475                 480 


Val Asp Val Asp Leu Gln Tyr Pro Gln Asp Ala Val Leu Ala Leu Thr 
                485                 490                 495     


Gln Asn His His Lys Gln Tyr Tyr Glu Gly Ser Glu Ile Val Val Ala 
            500                 505                 510         


Gly Arg Ile Ala Asp Asn Lys Gln Ser Ser Phe Lys Ala Asp Val Gln 
        515                 520                 525             


Ala His Gly Glu Gly Gln Glu Phe Ser Ile Thr Cys Leu Val Asp Glu 
    530                 535                 540                 


Glu Glu Met Lys Lys Leu Leu Arg Glu Arg Gly His Met Leu Glu Asn 
545                 550                 555                 560 


His Val Glu Arg Leu Trp Ala Tyr Leu Thr Ile Gln Glu Leu Leu Ala 
                565                 570                 575     


Lys Arg Met Lys Val Asp Arg Glu Glu Arg Ala Asn Leu Ser Ser Gln 
            580                 585                 590         


Ala Leu Gln Met Ser Leu Asp Tyr Gly Phe Val Thr Pro Leu Thr Ser 
        595                 600                 605             


Met Ser Ile Arg Gly Met Ala Asp Gln Asp Gly Leu Lys Pro Thr Ile 
    610                 615                 620                 


Asp Lys Pro Ser Glu Asp Ser Pro Pro Leu Glu Met Leu Gly Pro Arg 
625                 630                 635                 640 


Arg Thr Phe Val Leu Ser Ala Leu Gln Pro Ser Pro Thr His Ser Ser 
                645                 650                 655     


Ser Asn Thr Gln Arg Leu Pro Asp Arg Val Thr Gly Val Asp Thr Asp 
            660                 665                 670         


Pro His Phe Ile Ile His Val Pro Gln Lys Glu Asp Thr Leu Cys Phe 
        675                 680                 685             


Asn Ile Asn Glu Glu Pro Gly Val Ile Leu Ser Leu Val Gln Asp Pro 
    690                 695                 700                 


Asn Thr Gly Phe Ser Val Asn Gly Gln Leu Ile Gly Asn Lys Ala Arg 
705                 710                 715                 720 


Ser Pro Gly Gln His Asp Gly Thr Tyr Phe Gly Arg Leu Gly Ile Ala 
                725                 730                 735     


Asn Pro Ala Thr Asp Phe Gln Leu Glu Val Thr Pro Gln Asn Ile Thr 
            740                 745                 750         


Leu Asn Pro Gly Phe Gly Gly Pro Val Phe Ser Trp Arg Asp Gln Ala 
        755                 760                 765             


Val Leu Arg Gln Asp Gly Val Val Val Thr Ile Asn Lys Lys Arg Asn 
    770                 775                 780                 


Leu Val Val Ser Val Asp Asp Gly Gly Thr Phe Glu Val Val Leu His 
785                 790                 795                 800 


Arg Val Trp Lys Gly Ser Ser Val His Gln Asp Phe Leu Gly Phe Tyr 
                805                 810                 815     


Val Leu Asp Ser His Arg Met Ser Ala Arg Thr His Gly Leu Leu Gly 
            820                 825                 830         


Gln Phe Phe His Pro Ile Gly Phe Glu Val Ser Asp Ile His Pro Gly 
        835                 840                 845             


Ser Asp Pro Thr Lys Pro Asp Ala Thr Met Val Val Arg Asn Arg Arg 
    850                 855                 860                 


Leu Thr Val Thr Arg Gly Leu Gln Lys Asp Tyr Ser Lys Asp Pro Trp 
865                 870                 875                 880 


His Gly Ala Glu Val Ser Cys Trp Phe Ile His Asn Asn Gly Ala Gly 
                885                 890                 895     


Leu Ile Asp Gly Ala Tyr Thr Asp Tyr Ile Val Pro Asp Ile Phe 
            900                 905                 910     


<210>  2583
<211>  2695
<212>  PRT
<213>  Homo sapiens

<400>  2583

Met Ser Asp Lys Met Ser Ser Phe Leu His Ile Gly Asp Ile Cys Ser 
1               5                   10                  15      


Leu Tyr Ala Glu Gly Ser Thr Asn Gly Phe Ile Ser Thr Leu Gly Leu 
            20                  25                  30          


Val Asp Asp Arg Cys Val Val Gln Pro Glu Thr Gly Asp Leu Asn Asn 
        35                  40                  45              


Pro Pro Lys Lys Phe Arg Asp Cys Leu Phe Lys Leu Cys Pro Met Asn 
    50                  55                  60                  


Arg Tyr Ser Ala Gln Lys Gln Phe Trp Lys Ala Ala Lys Pro Gly Ala 
65                  70                  75                  80  


Asn Ser Thr Thr Asp Ala Val Leu Leu Asn Lys Leu His His Ala Ala 
                85                  90                  95      


Asp Leu Glu Lys Lys Gln Asn Glu Thr Glu Asn Arg Lys Leu Leu Gly 
            100                 105                 110         


Thr Val Ile Gln Tyr Gly Asn Val Ile Gln Leu Leu His Leu Lys Ser 
        115                 120                 125             


Asn Lys Tyr Leu Thr Val Asn Lys Arg Leu Pro Ala Leu Leu Glu Lys 
    130                 135                 140                 


Asn Ala Met Arg Val Thr Leu Asp Glu Ala Gly Asn Glu Gly Ser Trp 
145                 150                 155                 160 


Phe Tyr Ile Gln Pro Phe Tyr Lys Leu Arg Ser Ile Gly Asp Ser Val 
                165                 170                 175     


Val Ile Gly Asp Lys Val Val Leu Asn Pro Val Asn Ala Gly Gln Pro 
            180                 185                 190         


Leu His Ala Ser Ser His Gln Leu Val Asp Asn Pro Gly Cys Asn Glu 
        195                 200                 205             


Val Asn Ser Val Asn Cys Asn Thr Ser Trp Lys Ile Val Leu Phe Met 
    210                 215                 220                 


Lys Trp Ser Asp Asn Lys Asp Asp Ile Leu Lys Gly Gly Asp Val Val 
225                 230                 235                 240 


Arg Leu Phe His Ala Glu Gln Glu Lys Phe Leu Thr Cys Asp Glu His 
                245                 250                 255     


Arg Lys Lys Gln His Val Phe Leu Arg Thr Thr Gly Arg Gln Ser Ala 
            260                 265                 270         


Thr Ser Ala Thr Ser Ser Lys Ala Leu Trp Glu Val Glu Val Val Gln 
        275                 280                 285             


His Asp Pro Cys Arg Gly Gly Ala Gly Tyr Trp Asn Ser Leu Phe Arg 
    290                 295                 300                 


Phe Lys His Leu Ala Thr Gly His Tyr Leu Ala Ala Glu Val Asp Pro 
305                 310                 315                 320 


Asp Gln Asp Ala Ser Arg Ser Arg Leu Arg Asn Ala Gln Glu Lys Met 
                325                 330                 335     


Val Tyr Ser Leu Val Ser Val Pro Glu Gly Asn Asp Ile Ser Ser Ile 
            340                 345                 350         


Phe Glu Leu Asp Pro Thr Thr Leu Arg Gly Gly Asp Ser Leu Val Pro 
        355                 360                 365             


Arg Asn Ser Tyr Val Arg Leu Arg His Leu Cys Thr Asn Thr Trp Val 
    370                 375                 380                 


His Ser Thr Asn Ile Pro Ile Asp Lys Glu Glu Glu Lys Pro Val Met 
385                 390                 395                 400 


Leu Lys Ile Gly Thr Ser Pro Val Lys Glu Asp Lys Glu Ala Phe Ala 
                405                 410                 415     


Ile Val Pro Val Ser Pro Ala Glu Val Arg Asp Leu Asp Phe Ala Asn 
            420                 425                 430         


Asp Ala Ser Lys Val Leu Gly Ser Ile Ala Gly Lys Leu Glu Lys Gly 
        435                 440                 445             


Thr Ile Thr Gln Asn Glu Arg Arg Ser Val Thr Lys Leu Leu Glu Asp 
    450                 455                 460                 


Leu Val Tyr Phe Val Thr Gly Gly Thr Asn Ser Gly Gln Asp Val Leu 
465                 470                 475                 480 


Glu Val Val Phe Ser Lys Pro Asn Arg Glu Arg Gln Lys Leu Met Arg 
                485                 490                 495     


Glu Gln Asn Ile Leu Lys Gln Ile Phe Lys Leu Leu Gln Ala Pro Phe 
            500                 505                 510         


Thr Asp Cys Gly Asp Gly Pro Met Leu Arg Leu Glu Glu Leu Gly Asp 
        515                 520                 525             


Gln Arg His Ala Pro Phe Arg His Ile Cys Arg Leu Cys Tyr Arg Val 
    530                 535                 540                 


Leu Arg His Ser Gln Gln Asp Tyr Arg Lys Asn Gln Glu Tyr Ile Ala 
545                 550                 555                 560 


Lys Gln Phe Gly Phe Met Gln Lys Gln Ile Gly Tyr Asp Val Leu Ala 
                565                 570                 575     


Glu Asp Thr Ile Thr Ala Leu Leu His Asn Asn Arg Lys Leu Leu Glu 
            580                 585                 590         


Lys His Ile Thr Ala Ala Glu Ile Asp Thr Phe Val Ser Leu Val Arg 
        595                 600                 605             


Lys Asn Arg Glu Pro Arg Phe Leu Asp Tyr Leu Ser Asp Leu Cys Val 
    610                 615                 620                 


Ser Met Asn Lys Ser Ile Pro Val Thr Gln Glu Leu Ile Cys Lys Ala 
625                 630                 635                 640 


Val Leu Asn Pro Thr Asn Ala Asp Ile Leu Ile Glu Thr Lys Leu Val 
                645                 650                 655     


Leu Ser Arg Phe Glu Phe Glu Gly Val Ser Ser Thr Gly Glu Asn Ala 
            660                 665                 670         


Leu Glu Ala Gly Glu Asp Glu Glu Glu Val Trp Leu Phe Trp Arg Asp 
        675                 680                 685             


Ser Asn Lys Glu Ile Arg Ser Lys Ser Val Arg Glu Leu Ala Gln Asp 
    690                 695                 700                 


Ala Lys Glu Gly Gln Lys Glu Asp Arg Asp Val Leu Ser Tyr Tyr Arg 
705                 710                 715                 720 


Tyr Gln Leu Asn Leu Phe Ala Arg Met Cys Leu Asp Arg Gln Tyr Leu 
                725                 730                 735     


Ala Ile Asn Glu Ile Ser Gly Gln Leu Asp Val Asp Leu Ile Leu Arg 
            740                 745                 750         


Cys Met Ser Asp Glu Asn Leu Pro Tyr Asp Leu Arg Ala Ser Phe Cys 
        755                 760                 765             


Arg Leu Met Leu His Met His Val Asp Arg Asp Pro Gln Glu Gln Val 
    770                 775                 780                 


Thr Pro Val Lys Tyr Ala Arg Leu Trp Ser Glu Ile Pro Ser Glu Ile 
785                 790                 795                 800 


Ala Ile Asp Asp Tyr Asp Ser Ser Gly Ala Ser Lys Asp Glu Ile Lys 
                805                 810                 815     


Glu Arg Phe Ala Gln Thr Met Glu Phe Val Glu Glu Tyr Leu Arg Asp 
            820                 825                 830         


Val Val Cys Gln Arg Phe Pro Phe Ser Asp Lys Glu Lys Asn Lys Leu 
        835                 840                 845             


Thr Phe Glu Val Val Asn Leu Ala Arg Asn Leu Ile Tyr Phe Gly Phe 
    850                 855                 860                 


Tyr Asn Phe Ser Asp Leu Leu Arg Leu Thr Lys Ile Leu Leu Ala Ile 
865                 870                 875                 880 


Leu Asp Cys Val His Val Thr Thr Ile Phe Pro Ile Ser Lys Met Ala 
                885                 890                 895     


Lys Gly Glu Glu Asn Lys Gly Ser Asn Val Met Arg Ser Ile His Gly 
            900                 905                 910         


Val Gly Glu Leu Met Thr Gln Val Val Leu Arg Gly Gly Gly Phe Leu 
        915                 920                 925             


Pro Met Thr Pro Met Ala Ala Ala Pro Glu Gly Asn Val Lys Gln Ala 
    930                 935                 940                 


Glu Pro Glu Lys Glu Asp Ile Met Val Met Asp Thr Lys Leu Lys Ile 
945                 950                 955                 960 


Ile Glu Ile Leu Gln Phe Ile Leu Asn Val Arg Leu Asp Tyr Arg Ile 
                965                 970                 975     


Ser Cys Leu Leu Cys Ile Phe Lys Arg Glu Phe Asp Glu Ser Asn Ser 
            980                 985                 990         


Gln Thr Ser Glu Thr Ser Ser Gly  Asn Ser Ser Gln Glu  Gly Pro Ser 
        995                 1000                 1005             


Asn Val  Pro Gly Ala Leu Asp  Phe Glu His Ile Glu  Glu Gln Ala 
    1010                 1015                 1020             


Glu Gly  Ile Phe Gly Gly Ser  Glu Glu Asn Thr Pro  Leu Asp Leu 
    1025                 1030                 1035             


Asp Asp  His Gly Gly Arg Thr  Phe Leu Arg Val Leu  Leu His Leu 
    1040                 1045                 1050             


Thr Met  His Asp Tyr Pro Pro  Leu Val Ser Gly Ala  Leu Gln Leu 
    1055                 1060                 1065             


Leu Phe  Arg His Phe Ser Gln  Arg Gln Glu Val Leu  Gln Ala Phe 
    1070                 1075                 1080             


Lys Gln  Val Gln Leu Leu Val  Thr Ser Gln Asp Val  Asp Asn Tyr 
    1085                 1090                 1095             


Lys Gln  Ile Lys Gln Asp Leu  Asp Gln Leu Arg Ser  Ile Val Glu 
    1100                 1105                 1110             


Lys Ser  Glu Leu Trp Val Tyr  Lys Gly Gln Gly Pro  Asp Glu Thr 
    1115                 1120                 1125             


Met Asp  Gly Ala Ser Gly Glu  Asn Glu His Lys Lys  Thr Glu Glu 
    1130                 1135                 1140             


Gly Asn  Asn Lys Pro Gln Lys  His Glu Ser Thr Ser  Ser Tyr Asn 
    1145                 1150                 1155             


Tyr Arg  Val Val Lys Glu Ile  Leu Ile Arg Leu Ser  Lys Leu Cys 
    1160                 1165                 1170             


Val Gln  Glu Ser Ala Ser Val  Arg Lys Ser Arg Lys  Gln Gln Gln 
    1175                 1180                 1185             


Arg Leu  Leu Arg Asn Met Gly  Ala His Ala Val Val  Leu Glu Leu 
    1190                 1195                 1200             


Leu Gln  Ile Pro Tyr Glu Lys  Ala Glu Asp Thr Lys  Met Gln Glu 
    1205                 1210                 1215             


Ile Met  Arg Leu Ala His Glu  Phe Leu Gln Asn Phe  Cys Ala Gly 
    1220                 1225                 1230             


Asn Gln  Gln Asn Gln Ala Leu  Leu His Lys His Ile  Asn Leu Phe 
    1235                 1240                 1245             


Leu Asn  Pro Gly Ile Leu Glu  Ala Val Thr Met Gln  His Ile Phe 
    1250                 1255                 1260             


Met Asn  Asn Phe Gln Leu Cys  Ser Glu Ile Asn Glu  Arg Val Val 
    1265                 1270                 1275             


Gln His  Phe Val His Cys Ile  Glu Thr His Gly Arg  Asn Val Gln 
    1280                 1285                 1290             


Tyr Ile  Lys Phe Leu Gln Thr  Ile Val Lys Ala Glu  Gly Lys Phe 
    1295                 1300                 1305             


Ile Lys  Lys Cys Gln Asp Met  Val Met Ala Glu Leu  Val Asn Ser 
    1310                 1315                 1320             


Gly Glu  Asp Val Leu Val Phe  Tyr Asn Asp Arg Ala  Ser Phe Gln 
    1325                 1330                 1335             


Thr Leu  Ile Gln Met Met Arg  Ser Glu Arg Asp Arg  Met Asp Glu 
    1340                 1345                 1350             


Asn Ser  Pro Leu Met Tyr His  Ile His Leu Val Glu  Leu Leu Ala 
    1355                 1360                 1365             


Val Cys  Thr Glu Gly Lys Asn  Val Tyr Thr Glu Ile  Lys Cys Asn 
    1370                 1375                 1380             


Ser Leu  Leu Pro Leu Asp Asp  Ile Val Arg Val Val  Thr His Glu 
    1385                 1390                 1395             


Asp Cys  Ile Pro Glu Val Lys  Ile Ala Tyr Ile Asn  Phe Leu Asn 
    1400                 1405                 1410             


His Cys  Tyr Val Asp Thr Glu  Val Glu Met Lys Glu  Ile Tyr Thr 
    1415                 1420                 1425             


Ser Asn  His Met Trp Lys Leu  Phe Glu Asn Phe Leu  Val Asp Ile 
    1430                 1435                 1440             


Cys Arg  Ala Cys Asn Asn Thr  Ser Asp Arg Lys His  Ala Asp Ser 
    1445                 1450                 1455             


Ile Leu  Glu Lys Tyr Val Thr  Glu Ile Val Met Ser  Ile Val Thr 
    1460                 1465                 1470             


Thr Phe  Phe Ser Ser Pro Phe  Ser Asp Gln Ser Thr  Thr Leu Gln 
    1475                 1480                 1485             


Thr Arg  Gln Pro Val Phe Val  Gln Leu Leu Gln Gly  Val Phe Arg 
    1490                 1495                 1500             


Val Tyr  His Cys Asn Trp Leu  Met Pro Ser Gln Lys  Ala Ser Val 
    1505                 1510                 1515             


Glu Ser  Cys Ile Arg Val Leu  Ser Asp Val Ala Lys  Ser Arg Ala 
    1520                 1525                 1530             


Ile Ala  Ile Pro Val Asp Leu  Asp Ser Gln Val Asn  Asn Leu Phe 
    1535                 1540                 1545             


Leu Lys  Ser His Ser Ile Val  Gln Lys Thr Ala Met  Asn Trp Arg 
    1550                 1555                 1560             


Leu Ser  Ala Arg Asn Ala Ala  Arg Arg Asp Ser Val  Leu Ala Ala 
    1565                 1570                 1575             


Ser Arg  Asp Tyr Arg Asn Ile  Ile Glu Arg Leu Gln  Asp Ile Val 
    1580                 1585                 1590             


Ser Ala  Leu Glu Asp Arg Leu  Arg Pro Leu Val Gln  Ala Glu Leu 
    1595                 1600                 1605             


Ser Val  Leu Val Asp Val Leu  His Arg Pro Glu Leu  Leu Phe Pro 
    1610                 1615                 1620             


Glu Asn  Thr Asp Ala Arg Arg  Lys Cys Glu Ser Gly  Gly Phe Ile 
    1625                 1630                 1635             


Cys Lys  Leu Ile Lys His Thr  Lys Gln Leu Leu Glu  Glu Asn Glu 
    1640                 1645                 1650             


Glu Lys  Leu Cys Ile Lys Val  Leu Gln Thr Leu Arg  Glu Met Met 
    1655                 1660                 1665             


Thr Lys  Asp Arg Gly Tyr Gly  Glu Lys Gly Glu Ala  Leu Arg Gln 
    1670                 1675                 1680             


Val Leu  Val Asn Arg Tyr Tyr  Gly Asn Val Arg Pro  Ser Gly Arg 
    1685                 1690                 1695             


Arg Glu  Ser Leu Thr Ser Phe  Gly Asn Gly Pro Leu  Ser Ala Gly 
    1700                 1705                 1710             


Gly Pro  Gly Lys Pro Gly Gly  Gly Gly Gly Gly Ser  Gly Ser Ser 
    1715                 1720                 1725             


Ser Met  Ser Arg Gly Glu Met  Ser Leu Ala Glu Val  Gln Cys His 
    1730                 1735                 1740             


Leu Asp  Lys Glu Gly Ala Ser  Asn Leu Val Ile Asp  Leu Ile Met 
    1745                 1750                 1755             


Asn Ala  Ser Ser Asp Arg Val  Phe His Glu Ser Ile  Leu Leu Ala 
    1760                 1765                 1770             


Ile Ala  Leu Leu Glu Gly Gly  Asn Thr Thr Ile Gln  His Ser Phe 
    1775                 1780                 1785             


Phe Cys  Arg Leu Thr Glu Asp  Lys Lys Ser Glu Lys  Phe Phe Lys 
    1790                 1795                 1800             


Val Phe  Tyr Asp Arg Met Lys  Val Ala Gln Gln Glu  Ile Lys Ala 
    1805                 1810                 1815             


Thr Val  Thr Val Asn Thr Ser  Asp Leu Gly Asn Lys  Lys Lys Asp 
    1820                 1825                 1830             


Asp Glu  Val Asp Arg Asp Ala  Pro Ser Arg Lys Lys  Ala Lys Glu 
    1835                 1840                 1845             


Pro Thr  Thr Gln Ile Thr Glu  Glu Val Arg Asp Gln  Leu Leu Glu 
    1850                 1855                 1860             


Ala Ser  Ala Ala Thr Arg Lys  Ala Phe Thr Thr Phe  Arg Arg Glu 
    1865                 1870                 1875             


Ala Asp  Pro Asp Asp His Tyr  Gln Pro Gly Glu Gly  Thr Gln Ala 
    1880                 1885                 1890             


Thr Ala  Asp Lys Ala Lys Asp  Asp Leu Glu Met Ser  Ala Val Ile 
    1895                 1900                 1905             


Thr Ile  Met Gln Pro Ile Leu  Arg Phe Leu Gln Leu  Leu Cys Glu 
    1910                 1915                 1920             


Asn His  Asn Arg Asp Leu Gln  Asn Phe Leu Arg Cys  Gln Asn Asn 
    1925                 1930                 1935             


Lys Thr  Asn Tyr Asn Leu Val  Cys Glu Thr Leu Gln  Phe Leu Asp 
    1940                 1945                 1950             


Cys Ile  Cys Gly Ser Thr Thr  Gly Gly Leu Gly Leu  Leu Gly Leu 
    1955                 1960                 1965             


Tyr Ile  Asn Glu Lys Asn Val  Ala Leu Ile Asn Gln  Thr Leu Glu 
    1970                 1975                 1980             


Ser Leu  Thr Glu Tyr Cys Gln  Gly Pro Cys His Glu  Asn Gln Asn 
    1985                 1990                 1995             


Cys Ile  Ala Thr His Glu Ser  Asn Gly Ile Asp Ile  Ile Thr Ala 
    2000                 2005                 2010             


Leu Ile  Leu Asn Asp Ile Asn  Pro Leu Gly Lys Lys  Arg Met Asp 
    2015                 2020                 2025             


Leu Val  Leu Glu Leu Lys Asn  Asn Ala Ser Lys Leu  Leu Leu Ala 
    2030                 2035                 2040             


Ile Met  Glu Ser Arg His Asp  Ser Glu Asn Ala Glu  Arg Ile Leu 
    2045                 2050                 2055             


Tyr Asn  Met Arg Pro Lys Glu  Leu Val Glu Val Ile  Lys Lys Ala 
    2060                 2065                 2070             


Tyr Met  Gln Gly Glu Val Glu  Phe Glu Asp Gly Glu  Asn Gly Glu 
    2075                 2080                 2085             


Asp Gly  Ala Ala Ser Pro Arg  Asn Val Gly His Asn  Ile Tyr Ile 
    2090                 2095                 2100             


Leu Ala  His Gln Leu Ala Arg  His Asn Lys Glu Leu  Gln Ser Met 
    2105                 2110                 2115             


Leu Lys  Pro Gly Gly Gln Val  Asp Gly Asp Glu Ala  Leu Glu Phe 
    2120                 2125                 2130             


Tyr Ala  Lys His Thr Ala Gln  Ile Glu Ile Val Arg  Leu Asp Arg 
    2135                 2140                 2145             


Thr Met  Glu Gln Ile Val Phe  Pro Val Pro Ser Ile  Cys Glu Phe 
    2150                 2155                 2160             


Leu Thr  Lys Glu Ser Lys Leu  Arg Ile Tyr Tyr Thr  Thr Glu Arg 
    2165                 2170                 2175             


Asp Glu  Gln Gly Ser Lys Ile  Asn Asp Phe Phe Leu  Arg Ser Glu 
    2180                 2185                 2190             


Asp Leu  Phe Asn Glu Met Asn  Trp Gln Lys Lys Leu  Arg Ala Gln 
    2195                 2200                 2205             


Pro Val  Leu Tyr Trp Cys Ala  Arg Asn Met Ser Phe  Trp Ser Ser 
    2210                 2215                 2220             


Ile Ser  Phe Asn Leu Ala Val  Leu Met Asn Leu Leu  Val Ala Phe 
    2225                 2230                 2235             


Phe Tyr  Pro Phe Lys Gly Val  Arg Gly Gly Thr Leu  Glu Pro His 
    2240                 2245                 2250             


Trp Ser  Gly Leu Leu Trp Thr  Ala Met Leu Ile Ser  Leu Ala Ile 
    2255                 2260                 2265             


Val Ile  Ala Leu Pro Lys Pro  His Gly Ile Arg Ala  Leu Ile Ala 
    2270                 2275                 2280             


Ser Thr  Ile Leu Arg Leu Ile  Phe Ser Val Gly Leu  Gln Pro Thr 
    2285                 2290                 2295             


Leu Phe  Leu Leu Gly Ala Phe  Asn Val Cys Asn Lys  Ile Ile Phe 
    2300                 2305                 2310             


Leu Met  Ser Phe Val Gly Asn  Cys Gly Thr Phe Thr  Arg Gly Tyr 
    2315                 2320                 2325             


Arg Ala  Met Val Leu Asp Val  Glu Phe Leu Tyr His  Leu Leu Tyr 
    2330                 2335                 2340             


Leu Val  Ile Cys Ala Met Gly  Leu Phe Val His Glu  Phe Phe Tyr 
    2345                 2350                 2355             


Ser Leu  Leu Leu Phe Asp Leu  Val Tyr Arg Glu Glu  Thr Leu Leu 
    2360                 2365                 2370             


Asn Val  Ile Lys Ser Val Thr  Arg Asn Gly Arg Ser  Ile Ile Leu 
    2375                 2380                 2385             


Thr Ala  Val Leu Ala Leu Ile  Leu Val Tyr Leu Phe  Ser Ile Val 
    2390                 2395                 2400             


Gly Tyr  Leu Phe Phe Lys Asp  Asp Phe Ile Leu Glu  Val Asp Arg 
    2405                 2410                 2415             


Leu Pro  Asn Glu Thr Ala Val  Pro Glu Thr Gly Glu  Ser Leu Ala 
    2420                 2425                 2430             


Ser Glu  Phe Leu Phe Ser Asp  Val Cys Arg Val Glu  Ser Gly Glu 
    2435                 2440                 2445             


Asn Cys  Ser Ser Pro Ala Pro  Arg Glu Glu Leu Val  Pro Ala Glu 
    2450                 2455                 2460             


Glu Thr  Glu Gln Asp Lys Glu  His Thr Cys Glu Thr  Leu Leu Met 
    2465                 2470                 2475             


Cys Ile  Val Thr Val Leu Ser  His Gly Leu Arg Ser  Gly Gly Gly 
    2480                 2485                 2490             


Val Gly  Asp Val Leu Arg Lys  Pro Ser Lys Glu Glu  Pro Leu Phe 
    2495                 2500                 2505             


Ala Ala  Arg Val Ile Tyr Asp  Leu Leu Phe Phe Phe  Met Val Ile 
    2510                 2515                 2520             


Ile Ile  Val Leu Asn Leu Ile  Phe Gly Val Ile Ile  Asp Thr Phe 
    2525                 2530                 2535             


Ala Asp  Leu Arg Ser Glu Lys  Gln Lys Lys Glu Glu  Ile Leu Lys 
    2540                 2545                 2550             


Thr Thr  Cys Phe Ile Cys Gly  Leu Glu Arg Asp Lys  Phe Asp Asn 
    2555                 2560                 2565             


Lys Thr  Val Thr Phe Glu Glu  His Ile Lys Glu Glu  His Asn Met 
    2570                 2575                 2580             


Trp His  Tyr Leu Cys Phe Ile  Val Leu Val Lys Val  Lys Asp Ser 
    2585                 2590                 2595             


Thr Glu  Tyr Thr Gly Pro Glu  Ser Tyr Val Ala Glu  Met Ile Lys 
    2600                 2605                 2610             


Glu Arg  Asn Leu Asp Trp Phe  Pro Arg Met Arg Ala  Met Ser Leu 
    2615                 2620                 2625             


Val Ser  Ser Asp Ser Glu Gly  Glu Gln Asn Glu Leu  Arg Asn Leu 
    2630                 2635                 2640             


Gln Glu  Lys Leu Glu Ser Thr  Met Lys Leu Val Thr  Asn Leu Ser 
    2645                 2650                 2655             


Gly Gln  Leu Ser Glu Leu Lys  Asp Gln Met Thr Glu  Gln Arg Lys 
    2660                 2665                 2670             


Gln Lys  Gln Arg Ile Gly Leu  Leu Gly His Pro Pro  His Met Asn 
    2675                 2680                 2685             


Val Asn  Pro Gln Gln Pro Ala  
    2690                 2695 


<210>  2584
<211>  2701
<212>  PRT
<213>  Homo sapiens

<400>  2584

Met Thr Glu Lys Met Ser Ser Phe Leu Tyr Ile Gly Asp Ile Val Ser 
1               5                   10                  15      


Leu Tyr Ala Glu Gly Ser Val Asn Gly Phe Ile Ser Thr Leu Gly Leu 
            20                  25                  30          


Val Asp Asp Arg Cys Val Val His Pro Glu Ala Gly Asp Leu Ala Asn 
        35                  40                  45              


Pro Pro Lys Lys Phe Arg Asp Cys Leu Phe Lys Val Cys Pro Met Asn 
    50                  55                  60                  


Arg Tyr Ser Ala Gln Lys Gln Tyr Trp Lys Ala Lys Gln Ala Lys Gln 
65                  70                  75                  80  


Gly Asn His Thr Glu Ala Ala Leu Leu Lys Lys Leu Gln His Ala Ala 
                85                  90                  95      


Glu Leu Glu Gln Lys Gln Asn Glu Ser Glu Asn Lys Lys Leu Leu Gly 
            100                 105                 110         


Glu Ile Val Lys Tyr Ser Asn Val Ile Gln Leu Leu His Ile Lys Ser 
        115                 120                 125             


Asn Lys Tyr Leu Thr Val Asn Lys Arg Leu Pro Ala Leu Leu Glu Lys 
    130                 135                 140                 


Asn Ala Met Arg Val Ser Leu Asp Ala Ala Gly Asn Glu Gly Ser Trp 
145                 150                 155                 160 


Phe Tyr Ile His Pro Phe Trp Lys Leu Arg Ser Glu Gly Asp Asn Ile 
                165                 170                 175     


Val Val Gly Asp Lys Val Val Leu Met Pro Val Asn Ala Gly Gln Pro 
            180                 185                 190         


Leu His Ala Ser Asn Ile Glu Leu Leu Asp Asn Pro Gly Cys Lys Glu 
        195                 200                 205             


Val Asn Ala Val Asn Cys Asn Thr Ser Trp Lys Ile Thr Leu Phe Met 
    210                 215                 220                 


Lys Tyr Ser Ser Tyr Arg Glu Asp Val Leu Lys Gly Gly Asp Val Val 
225                 230                 235                 240 


Arg Leu Phe His Ala Glu Gln Glu Lys Phe Leu Thr Cys Asp Glu Tyr 
                245                 250                 255     


Glu Lys Lys Gln His Ile Phe Leu Arg Thr Thr Leu Arg Gln Ser Ala 
            260                 265                 270         


Thr Ser Ala Thr Ser Ser Lys Ala Leu Trp Glu Ile Glu Val Val His 
        275                 280                 285             


His Asp Pro Cys Arg Gly Gly Ala Gly Gln Trp Asn Ser Leu Phe Arg 
    290                 295                 300                 


Phe Lys His Leu Ala Thr Gly Asn Tyr Leu Ala Ala Glu Leu Asn Pro 
305                 310                 315                 320 


Asp Tyr Arg Asp Ala Gln Asn Glu Gly Lys Asn Val Arg Asp Gly Val 
                325                 330                 335     


Pro Pro Thr Ser Lys Lys Lys Arg Gln Ala Gly Glu Lys Ile Met Tyr 
            340                 345                 350         


Thr Leu Val Ser Val Pro His Gly Asn Asp Ile Ala Ser Leu Phe Glu 
        355                 360                 365             


Leu Asp Ala Thr Thr Leu Gln Arg Ala Asp Cys Leu Val Pro Arg Asn 
    370                 375                 380                 


Ser Tyr Val Arg Leu Arg His Leu Cys Thr Asn Thr Trp Val Thr Ser 
385                 390                 395                 400 


Thr Ser Ile Pro Ile Asp Thr Asp Glu Glu Arg Pro Val Met Leu Lys 
                405                 410                 415     


Ile Gly Thr Cys Gln Thr Lys Glu Asp Lys Glu Ala Phe Ala Ile Val 
            420                 425                 430         


Ser Val Pro Leu Ser Glu Val Arg Asp Leu Asp Phe Ala Asn Asp Ala 
        435                 440                 445             


Asn Lys Val Leu Ala Thr Thr Val Lys Lys Leu Glu Asn Gly Thr Ile 
    450                 455                 460                 


Thr Gln Asn Glu Arg Arg Phe Val Thr Lys Leu Leu Glu Asp Leu Ile 
465                 470                 475                 480 


Phe Phe Val Ala Asp Val Pro Asn Asn Gly Gln Glu Val Leu Asp Val 
                485                 490                 495     


Val Ile Thr Lys Pro Asn Arg Glu Arg Gln Lys Leu Met Arg Glu Gln 
            500                 505                 510         


Asn Ile Leu Ala Gln Val Phe Gly Ile Leu Lys Ala Pro Phe Lys Glu 
        515                 520                 525             


Lys Ala Gly Glu Gly Ser Met Leu Arg Leu Glu Asp Leu Gly Asp Gln 
    530                 535                 540                 


Arg Tyr Ala Pro Tyr Lys Tyr Met Leu Arg Leu Cys Tyr Arg Val Leu 
545                 550                 555                 560 


Arg His Ser Gln Gln Asp Tyr Arg Lys Asn Gln Glu Tyr Ile Ala Lys 
                565                 570                 575     


Asn Phe Cys Val Met Gln Ser Gln Ile Gly Tyr Asp Ile Leu Ala Glu 
            580                 585                 590         


Asp Thr Ile Thr Ala Leu Leu His Asn Asn Arg Lys Leu Leu Glu Lys 
        595                 600                 605             


His Ile Thr Ala Lys Glu Ile Glu Thr Phe Val Ser Leu Leu Arg Arg 
    610                 615                 620                 


Asn Arg Glu Pro Arg Phe Leu Asp Tyr Leu Ser Asp Leu Cys Val Ser 
625                 630                 635                 640 


Asn Thr Thr Ala Ile Pro Val Thr Gln Glu Leu Ile Cys Lys Phe Met 
                645                 650                 655     


Leu Ser Pro Gly Asn Ala Asp Ile Leu Ile Gln Thr Lys Val Val Ser 
            660                 665                 670         


Met Gln Ala Asp Asn Pro Met Glu Ser Ser Ile Leu Ser Asp Asp Ile 
        675                 680                 685             


Asp Asp Glu Glu Val Trp Leu Tyr Trp Ile Asp Ser Asn Lys Glu Pro 
    690                 695                 700                 


His Gly Lys Ala Ile Arg His Leu Ala Gln Glu Ala Lys Glu Gly Thr 
705                 710                 715                 720 


Lys Ala Asp Leu Glu Val Leu Thr Tyr Tyr Arg Tyr Gln Leu Asn Leu 
                725                 730                 735     


Phe Ala Arg Met Cys Leu Asp Arg Gln Tyr Leu Ala Ile Asn Gln Ile 
            740                 745                 750         


Ser Thr Gln Leu Ser Val Asp Leu Ile Leu Arg Cys Val Ser Asp Glu 
        755                 760                 765             


Ser Leu Pro Phe Asp Leu Arg Ala Ser Phe Cys Arg Leu Met Leu His 
    770                 775                 780                 


Met His Val Asp Arg Asp Pro Gln Glu Ser Val Val Pro Val Arg Tyr 
785                 790                 795                 800 


Ala Arg Leu Trp Thr Glu Ile Pro Thr Lys Ile Thr Ile His Glu Tyr 
                805                 810                 815     


Asp Ser Ile Thr Asp Ser Ser Arg Asn Asp Met Lys Arg Lys Phe Ala 
            820                 825                 830         


Leu Thr Met Glu Phe Val Glu Glu Tyr Leu Lys Glu Val Val Asn Gln 
        835                 840                 845             


Pro Phe Pro Phe Gly Asp Lys Glu Lys Asn Lys Leu Thr Phe Glu Val 
    850                 855                 860                 


Val His Leu Ala Arg Asn Leu Ile Tyr Phe Gly Phe Tyr Ser Phe Ser 
865                 870                 875                 880 


Glu Leu Leu Arg Leu Thr Arg Thr Leu Leu Ala Ile Leu Asp Ile Val 
                885                 890                 895     


Gln Ala Pro Met Ser Ser Tyr Phe Glu Arg Leu Ser Lys Phe Gln Asp 
            900                 905                 910         


Gly Gly Asn Asn Val Met Arg Thr Ile His Gly Val Gly Glu Met Met 
        915                 920                 925             


Thr Gln Met Val Leu Ser Arg Gly Ser Ile Phe Pro Met Ser Val Pro 
    930                 935                 940                 


Asp Val Pro Pro Ser Ile His Pro Ser Lys Gln Gly Ser Pro Thr Glu 
945                 950                 955                 960 


His Glu Asp Val Thr Val Met Asp Thr Lys Leu Lys Ile Ile Glu Ile 
                965                 970                 975     


Leu Gln Phe Ile Leu Ser Val Arg Leu Asp Tyr Arg Ile Ser Tyr Met 
            980                 985                 990         


Leu Ser Ile Tyr Lys Lys Glu Phe  Gly Glu Asp Asn Asp  Asn Ala Glu 
        995                 1000                 1005             


Thr Ser  Ala Ser Gly Ser Pro  Asp Thr Leu Leu Pro  Ser Ala Ile 
    1010                 1015                 1020             


Val Pro  Asp Ile Asp Glu Ile  Ala Ala Gln Ala Glu  Thr Met Phe 
    1025                 1030                 1035             


Ala Gly  Arg Lys Glu Lys Asn  Pro Val Gln Leu Asp  Asp Glu Gly 
    1040                 1045                 1050             


Gly Arg  Thr Phe Leu Arg Val  Leu Ile His Leu Ile  Met His Asp 
    1055                 1060                 1065             


Tyr Pro  Pro Leu Leu Ser Gly  Ala Leu Gln Leu Leu  Phe Lys His 
    1070                 1075                 1080             


Phe Ser  Gln Arg Ala Glu Val  Leu Gln Ala Phe Lys  Gln Val Gln 
    1085                 1090                 1095             


Leu Leu  Val Ser Asn Gln Asp  Val Asp Asn Tyr Lys  Gln Ile Lys 
    1100                 1105                 1110             


Ala Asp  Leu Asp Gln Leu Arg  Leu Thr Val Glu Lys  Ser Glu Leu 
    1115                 1120                 1125             


Trp Val  Glu Lys Ser Ser Asn  Tyr Glu Asn Gly Glu  Ile Gly Glu 
    1130                 1135                 1140             


Ser Gln  Val Lys Gly Gly Glu  Glu Pro Ile Glu Glu  Ser Asn Ile 
    1145                 1150                 1155             


Leu Ser  Pro Val Gln Asp Gly  Thr Lys Lys Pro Gln  Ile Asp Ser 
    1160                 1165                 1170             


Asn Lys  Ser Asn Asn Tyr Arg  Ile Val Lys Glu Ile  Leu Ile Arg 
    1175                 1180                 1185             


Leu Ser  Lys Leu Cys Val Gln  Asn Lys Lys Cys Arg  Asn Gln His 
    1190                 1195                 1200             


Gln Arg  Leu Leu Lys Asn Met  Gly Ala His Ser Val  Val Leu Asp 
    1205                 1210                 1215             


Leu Leu  Gln Ile Pro Tyr Glu  Lys Asn Asp Glu Lys  Met Asn Glu 
    1220                 1225                 1230             


Val Met  Asn Leu Ala His Thr  Phe Leu Gln Asn Phe  Cys Arg Gly 
    1235                 1240                 1245             


Asn Pro  Gln Asn Gln Val Leu  Leu His Lys His Leu  Asn Leu Phe 
    1250                 1255                 1260             


Leu Thr  Pro Gly Leu Leu Glu  Ala Glu Thr Met Arg  His Ile Phe 
    1265                 1270                 1275             


Met Asn  Asn Tyr His Leu Cys  Asn Glu Ile Ser Glu  Arg Val Val 
    1280                 1285                 1290             


Gln His  Phe Val His Cys Ile  Glu Thr His Gly Arg  His Val Glu 
    1295                 1300                 1305             


Tyr Leu  Arg Phe Leu Gln Thr  Ile Val Lys Ala Asp  Gly Lys Tyr 
    1310                 1315                 1320             


Val Lys  Lys Cys Gln Asp Met  Val Met Thr Glu Leu  Ile Asn Gly 
    1325                 1330                 1335             


Gly Glu  Asp Val Leu Ile Phe  Tyr Asn Asp Arg Ala  Ser Phe Pro 
    1340                 1345                 1350             


Ile Leu  Leu His Met Met Cys  Ser Glu Arg Asp Arg  Gly Asp Glu 
    1355                 1360                 1365             


Ser Gly  Pro Leu Ala Tyr His  Ile Thr Leu Val Glu  Leu Leu Ala 
    1370                 1375                 1380             


Ala Cys  Thr Glu Gly Lys Asn  Val Tyr Thr Glu Ile  Lys Cys Asn 
    1385                 1390                 1395             


Ser Leu  Leu Pro Leu Asp Asp  Ile Val Arg Val Val  Thr His Asp 
    1400                 1405                 1410             


Asp Cys  Ile Pro Glu Val Lys  Ile Ala Tyr Val Asn  Phe Val Asn 
    1415                 1420                 1425             


His Cys  Tyr Val Asp Thr Glu  Val Glu Met Lys Glu  Ile Tyr Thr 
    1430                 1435                 1440             


Ser Asn  His Ile Trp Lys Leu  Phe Glu Asn Phe Leu  Val Asp Met 
    1445                 1450                 1455             


Ala Arg  Val Cys Asn Thr Thr  Thr Asp Arg Lys His  Ala Asp Ile 
    1460                 1465                 1470             


Phe Leu  Glu Lys Cys Val Thr  Glu Ser Ile Met Asn  Ile Val Ser 
    1475                 1480                 1485             


Gly Phe  Phe Asn Ser Pro Phe  Ser Asp Asn Ser Thr  Ser Leu Gln 
    1490                 1495                 1500             


Thr His  Gln Pro Val Phe Ile  Gln Leu Leu Gln Ser  Ala Phe Arg 
    1505                 1510                 1515             


Ile Tyr  Asn Cys Thr Trp Pro  Asn Pro Ala Gln Lys  Ala Ser Val 
    1520                 1525                 1530             


Glu Ser  Cys Ile Arg Thr Leu  Ala Glu Val Ala Lys  Asn Arg Gly 
    1535                 1540                 1545             


Ile Ala  Ile Pro Val Asp Leu  Asp Ser Gln Val Asn  Thr Leu Phe 
    1550                 1555                 1560             


Met Lys  Ser His Ser Asn Met  Val Gln Arg Ala Ala  Met Gly Trp 
    1565                 1570                 1575             


Arg Leu  Ser Ala Arg Ser Gly  Pro Arg Phe Lys Glu  Ala Leu Gly 
    1580                 1585                 1590             


Gly Pro  Ala Trp Asp Tyr Arg  Asn Ile Ile Glu Lys  Leu Gln Asp 
    1595                 1600                 1605             


Val Val  Ala Ser Leu Glu His  Gln Phe Ser Pro Met  Met Gln Ala 
    1610                 1615                 1620             


Glu Phe  Ser Val Leu Val Asp  Val Leu Tyr Ser Pro  Glu Leu Leu 
    1625                 1630                 1635             


Phe Pro  Glu Gly Ser Asp Ala  Arg Ile Arg Cys Gly  Ala Phe Met 
    1640                 1645                 1650             


Ser Lys  Leu Ile Asn His Thr  Lys Lys Leu Met Glu  Lys Glu Glu 
    1655                 1660                 1665             


Lys Leu  Cys Ile Lys Ile Leu  Gln Thr Leu Arg Glu  Met Leu Glu 
    1670                 1675                 1680             


Lys Lys  Asp Ser Phe Val Glu  Glu Gly Asn Thr Leu  Arg Lys Ile 
    1685                 1690                 1695             


Leu Leu  Asn Arg Tyr Phe Lys  Gly Asp Tyr Ser Ile  Gly Val Asn 
    1700                 1705                 1710             


Gly His  Leu Ser Gly Ala Tyr  Ser Lys Thr Ala Gln  Val Gly Gly 
    1715                 1720                 1725             


Ser Phe  Ser Gly Gln Asp Ser  Asp Lys Met Gly Ile  Ser Met Ser 
    1730                 1735                 1740             


Asp Ile  Gln Cys Leu Leu Asp  Lys Glu Gly Ala Ser  Glu Leu Val 
    1745                 1750                 1755             


Ile Asp  Val Ile Val Asn Thr  Lys Asn Asp Arg Ile  Phe Ser Glu 
    1760                 1765                 1770             


Gly Ile  Phe Leu Gly Ile Ala  Leu Leu Glu Gly Gly  Asn Thr Gln 
    1775                 1780                 1785             


Thr Gln  Tyr Ser Phe Tyr Gln  Gln Leu His Glu Gln  Lys Lys Ser 
    1790                 1795                 1800             


Glu Lys  Phe Phe Lys Val Leu  Tyr Asp Arg Met Lys  Ala Ala Gln 
    1805                 1810                 1815             


Lys Glu  Ile Arg Ser Thr Val  Thr Val Asn Thr Ile  Asp Leu Gly 
    1820                 1825                 1830             


Asn Lys  Lys Arg Asp Asp Asp  Asn Glu Leu Met Thr  Ser Gly Pro 
    1835                 1840                 1845             


Arg Met  Arg Val Arg Asp Ser  Thr Leu His Leu Lys  Glu Gly Met 
    1850                 1855                 1860             


Lys Gly  Gln Leu Thr Glu Ala  Ser Ser Ala Thr Ser  Lys Ala Tyr 
    1865                 1870                 1875             


Cys Val  Tyr Arg Arg Glu Met  Asp Pro Glu Ile Asp  Ile Met Cys 
    1880                 1885                 1890             


Thr Gly  Pro Glu Ala Gly Asn  Thr Glu Glu Lys Ser  Ala Glu Glu 
    1895                 1900                 1905             


Val Thr  Met Ser Pro Ala Ile  Ala Ile Met Gln Pro  Ile Leu Arg 
    1910                 1915                 1920             


Phe Leu  Gln Leu Leu Cys Glu  Asn His Asn Arg Glu  Leu Gln Asn 
    1925                 1930                 1935             


Phe Leu  Arg Asn Gln Asn Asn  Lys Thr Asn Tyr Asn  Leu Val Cys 
    1940                 1945                 1950             


Glu Thr  Leu Gln Phe Leu Asp  Cys Ile Cys Gly Ser  Thr Thr Gly 
    1955                 1960                 1965             


Gly Leu  Gly Leu Leu Gly Leu  Tyr Ile Asn Glu Lys  Asn Val Ala 
    1970                 1975                 1980             


Leu Val  Asn Gln Asn Leu Glu  Ser Leu Thr Glu Tyr  Cys Gln Gly 
    1985                 1990                 1995             


Pro Cys  His Glu Asn Gln Thr  Cys Ile Ala Thr His  Glu Ser Asn 
    2000                 2005                 2010             


Gly Ile  Asp Ile Ile Ile Ala  Leu Ile Leu Asn Asp  Ile Asn Pro 
    2015                 2020                 2025             


Leu Gly  Lys Tyr Arg Met Asp  Leu Val Leu Gln Leu  Lys Asn Asn 
    2030                 2035                 2040             


Ala Ser  Lys Leu Leu Leu Ala  Ile Met Glu Ser Arg  His Asp Ser 
    2045                 2050                 2055             


Glu Asn  Ala Glu Arg Ile Leu  Phe Asn Met Arg Pro  Arg Glu Leu 
    2060                 2065                 2070             


Val Asp  Val Met Lys Asn Ala  Tyr Asn Gln Gly Leu  Glu Cys Asp 
    2075                 2080                 2085             


His Gly  Asp Asp Glu Gly Gly  Asp Asp Gly Val Ser  Pro Lys Asp 
    2090                 2095                 2100             


Val Gly  His Asn Ile Tyr Ile  Leu Ala His Gln Leu  Ala Arg His 
    2105                 2110                 2115             


Asn Lys  Leu Leu Gln Gln Met  Leu Lys Pro Gly Ser  Asp Pro Asp 
    2120                 2125                 2130             


Glu Gly  Asp Glu Ala Leu Lys  Tyr Tyr Ala Asn His  Thr Ala Gln 
    2135                 2140                 2145             


Ile Glu  Ile Val Arg His Asp  Arg Thr Met Glu Gln  Ile Val Phe 
    2150                 2155                 2160             


Pro Val  Pro Asn Ile Cys Glu  Tyr Leu Thr Arg Glu  Ser Lys Cys 
    2165                 2170                 2175             


Arg Val  Phe Asn Thr Thr Glu  Arg Asp Glu Gln Gly  Ser Lys Val 
    2180                 2185                 2190             


Asn Asp  Phe Phe Gln Gln Thr  Glu Asp Leu Tyr Asn  Glu Met Lys 
    2195                 2200                 2205             


Trp Gln  Lys Lys Ile Arg Asn  Asn Pro Ala Leu Phe  Trp Phe Ser 
    2210                 2215                 2220             


Arg His  Ile Ser Leu Trp Gly  Ser Ile Ser Phe Asn  Leu Ala Val 
    2225                 2230                 2235             


Phe Ile  Asn Leu Ala Val Ala  Leu Phe Tyr Pro Phe  Gly Asp Asp 
    2240                 2245                 2250             


Gly Asp  Glu Gly Thr Leu Ser  Pro Leu Phe Ser Val  Leu Leu Trp 
    2255                 2260                 2265             


Ile Ala  Val Ala Ile Cys Thr  Ser Met Leu Phe Phe  Phe Ser Lys 
    2270                 2275                 2280             


Pro Val  Gly Ile Arg Pro Phe  Leu Val Ser Ile Met  Leu Arg Ser 
    2285                 2290                 2295             


Ile Tyr  Thr Ile Gly Leu Gly  Pro Thr Leu Ile Leu  Leu Gly Ala 
    2300                 2305                 2310             


Ala Asn  Leu Cys Asn Lys Ile  Val Phe Leu Val Ser  Phe Val Gly 
    2315                 2320                 2325             


Asn Arg  Gly Thr Phe Thr Arg  Gly Tyr Arg Ala Val  Ile Leu Asp 
    2330                 2335                 2340             


Met Ala  Phe Leu Tyr His Val  Ala Tyr Val Leu Val  Cys Met Leu 
    2345                 2350                 2355             


Gly Leu  Phe Val His Glu Phe  Phe Tyr Ser Phe Leu  Leu Phe Asp 
    2360                 2365                 2370             


Leu Val  Tyr Arg Glu Glu Thr  Leu Leu Asn Val Ile  Lys Ser Val 
    2375                 2380                 2385             


Thr Arg  Asn Gly Arg Ser Ile  Ile Leu Thr Ala Val  Leu Ala Leu 
    2390                 2395                 2400             


Ile Leu  Val Tyr Leu Phe Ser  Ile Ile Gly Phe Leu  Phe Leu Lys 
    2405                 2410                 2415             


Asp Asp  Phe Thr Met Glu Val  Asp Arg Leu Lys Asn  Arg Thr Pro 
    2420                 2425                 2430             


Val Thr  Gly Ser His Gln Val  Pro Thr Met Thr Leu  Thr Thr Met 
    2435                 2440                 2445             


Met Glu  Ala Cys Ala Lys Glu  Asn Cys Ser Pro Thr  Ile Pro Ala 
    2450                 2455                 2460             


Ser Asn  Thr Ala Asp Glu Glu  Tyr Glu Asp Gly Ile  Glu Arg Thr 
    2465                 2470                 2475             


Cys Asp  Thr Leu Leu Met Cys  Ile Val Thr Val Leu  Asn Gln Gly 
    2480                 2485                 2490             


Leu Arg  Asn Gly Gly Gly Val  Gly Asp Val Leu Arg  Arg Pro Ser 
    2495                 2500                 2505             


Lys Asp  Glu Pro Leu Phe Ala  Ala Arg Val Val Tyr  Asp Leu Leu 
    2510                 2515                 2520             


Phe Tyr  Phe Ile Val Ile Ile  Ile Val Leu Asn Leu  Ile Phe Gly 
    2525                 2530                 2535             


Val Ile  Ile Asp Thr Phe Ala  Asp Leu Arg Ser Glu  Lys Gln Lys 
    2540                 2545                 2550             


Lys Glu  Glu Ile Leu Lys Thr  Thr Cys Phe Ile Cys  Gly Leu Glu 
    2555                 2560                 2565             


Arg Asp  Lys Phe Asp Asn Lys  Thr Val Ser Phe Glu  Glu His Ile 
    2570                 2575                 2580             


Lys Ser  Glu His Asn Met Trp  His Tyr Leu Tyr Phe  Ile Val Leu 
    2585                 2590                 2595             


Val Lys  Val Lys Asp Pro Thr  Glu Tyr Thr Gly Pro  Glu Ser Tyr 
    2600                 2605                 2610             


Val Ala  Gln Met Ile Val Glu  Lys Asn Leu Asp Trp  Phe Pro Arg 
    2615                 2620                 2625             


Met Arg  Ala Met Ser Leu Val  Ser Asn Glu Gly Asp  Ser Glu Gln 
    2630                 2635                 2640             


Asn Glu  Ile Arg Ser Leu Gln  Glu Lys Leu Glu Ser  Thr Met Ser 
    2645                 2650                 2655             


Leu Val  Lys Gln Leu Ser Gly  Gln Leu Ala Glu Leu  Lys Glu Gln 
    2660                 2665                 2670             


Met Thr  Glu Gln Arg Lys Asn  Lys Gln Arg Leu Gly  Phe Leu Gly 
    2675                 2680                 2685             


Ser Asn  Thr Pro His Val Asn  His His Met Pro Pro  His 
    2690                 2695                 2700     


<210>  2585
<211>  2671
<212>  PRT
<213>  Homo sapiens

<400>  2585

Met Ser Glu Met Ser Ser Phe Leu His Ile Gly Asp Ile Val Ser Leu 
1               5                   10                  15      


Tyr Ala Glu Gly Ser Val Asn Gly Phe Ile Ser Thr Leu Gly Leu Val 
            20                  25                  30          


Asp Asp Arg Cys Val Val Glu Pro Ala Ala Gly Asp Leu Asp Asn Pro 
        35                  40                  45              


Pro Lys Lys Phe Arg Asp Cys Leu Phe Lys Val Cys Pro Met Asn Arg 
    50                  55                  60                  


Tyr Ser Ala Gln Lys Gln Tyr Trp Lys Ala Lys Gln Thr Lys Gln Asp 
65                  70                  75                  80  


Lys Glu Lys Ile Ala Asp Val Val Leu Leu Gln Lys Leu Gln His Ala 
                85                  90                  95      


Ala Gln Met Glu Gln Lys Gln Asn Asp Thr Glu Asn Lys Lys Val His 
            100                 105                 110         


Gly Asp Val Val Lys Tyr Gly Ser Val Ile Gln Leu Leu His Met Lys 
        115                 120                 125             


Ser Asn Lys Tyr Leu Thr Val Asn Lys Arg Leu Pro Ala Leu Leu Glu 
    130                 135                 140                 


Lys Asn Ala Met Arg Val Thr Leu Asp Ala Thr Gly Asn Glu Gly Ser 
145                 150                 155                 160 


Trp Leu Phe Ile Gln Pro Phe Trp Lys Leu Arg Ser Asn Gly Asp Asn 
                165                 170                 175     


Val Val Val Gly Asp Lys Val Ile Leu Asn Pro Val Asn Ala Gly Gln 
            180                 185                 190         


Pro Leu His Ala Ser Asn Tyr Glu Leu Ser Asp Asn Ala Gly Cys Lys 
        195                 200                 205             


Glu Val Asn Ser Val Asn Cys Asn Thr Ser Trp Lys Ile Asn Leu Phe 
    210                 215                 220                 


Met Gln Phe Arg Asp His Leu Glu Glu Val Leu Lys Gly Gly Asp Val 
225                 230                 235                 240 


Val Arg Leu Phe His Ala Glu Gln Glu Lys Phe Leu Thr Cys Asp Glu 
                245                 250                 255     


Tyr Lys Gly Lys Leu Gln Val Phe Leu Arg Thr Thr Leu Arg Gln Ser 
            260                 265                 270         


Ala Thr Ser Ala Thr Ser Ser Asn Ala Leu Trp Glu Val Glu Val Val 
        275                 280                 285             


His His Asp Pro Cys Arg Gly Gly Ala Gly His Trp Asn Gly Leu Tyr 
    290                 295                 300                 


Arg Phe Lys His Leu Ala Thr Gly Asn Tyr Leu Ala Ala Glu Glu Asn 
305                 310                 315                 320 


Pro Ser Tyr Lys Gly Asp Ala Ser Asp Pro Lys Ala Ala Gly Met Gly 
                325                 330                 335     


Ala Gln Gly Arg Thr Gly Arg Arg Asn Ala Gly Glu Lys Ile Lys Tyr 
            340                 345                 350         


Cys Leu Val Ala Val Pro His Gly Asn Asp Ile Ala Ser Leu Phe Glu 
        355                 360                 365             


Leu Asp Pro Thr Thr Leu Gln Lys Thr Asp Ser Phe Val Pro Arg Asn 
    370                 375                 380                 


Ser Tyr Val Arg Leu Arg His Leu Cys Thr Asn Thr Trp Ile Gln Ser 
385                 390                 395                 400 


Thr Asn Val Pro Ile Asp Ile Glu Glu Glu Arg Pro Ile Arg Leu Met 
                405                 410                 415     


Leu Gly Thr Cys Pro Thr Lys Glu Asp Lys Glu Ala Phe Ala Ile Val 
            420                 425                 430         


Ser Val Pro Val Ser Glu Ile Arg Asp Leu Asp Phe Ala Asn Asp Ala 
        435                 440                 445             


Ser Ser Met Leu Ala Ser Ala Val Glu Lys Leu Asn Glu Gly Phe Ile 
    450                 455                 460                 


Ser Gln Asn Asp Arg Arg Phe Val Ile Gln Leu Leu Glu Asp Leu Val 
465                 470                 475                 480 


Phe Phe Val Ser Asp Val Pro Asn Asn Gly Gln Asn Val Leu Asp Ile 
                485                 490                 495     


Met Val Thr Lys Pro Asn Arg Glu Arg Gln Lys Leu Met Arg Glu Gln 
            500                 505                 510         


Asn Ile Leu Lys Gln Val Phe Gly Ile Leu Lys Ala Pro Phe Arg Glu 
        515                 520                 525             


Lys Gly Gly Glu Gly Pro Leu Val Arg Leu Glu Glu Leu Ser Asp Gln 
    530                 535                 540                 


Lys Asn Ala Pro Tyr Gln His Met Phe Arg Leu Cys Tyr Arg Val Leu 
545                 550                 555                 560 


Arg His Ser Gln Glu Asp Tyr Arg Lys Asn Gln Glu His Ile Ala Lys 
                565                 570                 575     


Gln Phe Gly Met Met Gln Ser Gln Ile Gly Tyr Asp Ile Leu Ala Glu 
            580                 585                 590         


Asp Thr Ile Thr Ala Leu Leu His Asn Asn Arg Lys Leu Leu Glu Lys 
        595                 600                 605             


His Ile Thr Lys Thr Glu Val Glu Thr Phe Val Ser Leu Val Arg Lys 
    610                 615                 620                 


Asn Arg Glu Pro Arg Phe Leu Asp Tyr Leu Ser Asp Leu Cys Val Ser 
625                 630                 635                 640 


Asn His Ile Ala Ile Pro Val Thr Gln Glu Leu Ile Cys Lys Cys Val 
                645                 650                 655     


Leu Asp Pro Lys Asn Ser Asp Ile Leu Ile Arg Thr Glu Leu Arg Pro 
            660                 665                 670         


Val Lys Glu Met Ala Gln Ser His Glu Tyr Leu Ser Ile Glu Tyr Ser 
        675                 680                 685             


Glu Glu Glu Val Trp Leu Thr Trp Thr Asp Lys Asn Asn Glu His His 
    690                 695                 700                 


Glu Lys Ser Val Arg Gln Leu Ala Gln Glu Ala Arg Ala Gly Asn Ala 
705                 710                 715                 720 


His Asp Glu Asn Val Leu Ser Tyr Tyr Arg Tyr Gln Leu Lys Leu Phe 
                725                 730                 735     


Ala Arg Met Cys Leu Asp Arg Gln Tyr Leu Ala Ile Asp Glu Ile Ser 
            740                 745                 750         


Gln Gln Leu Gly Val Asp Leu Ile Phe Leu Cys Met Ala Asp Glu Met 
        755                 760                 765             


Leu Pro Phe Asp Leu Arg Ala Ser Phe Cys His Leu Met Leu His Val 
    770                 775                 780                 


His Val Asp Arg Asp Pro Gln Glu Leu Val Thr Pro Val Lys Phe Ala 
785                 790                 795                 800 


Arg Leu Trp Thr Glu Ile Pro Thr Ala Ile Thr Ile Lys Asp Tyr Asp 
                805                 810                 815     


Ser Asn Leu Asn Ala Ser Arg Asp Asp Lys Lys Asn Lys Phe Ala Asn 
            820                 825                 830         


Thr Met Glu Phe Val Glu Asp Tyr Leu Asn Asn Val Val Ser Glu Ala 
        835                 840                 845             


Val Pro Phe Ala Asn Glu Glu Lys Asn Lys Leu Thr Phe Glu Val Val 
    850                 855                 860                 


Ser Leu Ala His Asn Leu Ile Tyr Phe Gly Phe Tyr Ser Phe Ser Glu 
865                 870                 875                 880 


Leu Leu Arg Leu Thr Arg Thr Leu Leu Gly Ile Ile Asp Cys Val Gln 
                885                 890                 895     


Gly Pro Pro Ala Met Leu Gln Ala Tyr Glu Asp Pro Gly Gly Lys Asn 
            900                 905                 910         


Val Arg Arg Ser Ile Gln Gly Val Gly His Met Met Ser Thr Met Val 
        915                 920                 925             


Leu Ser Arg Lys Gln Ser Val Phe Ser Ala Pro Ser Leu Ser Ala Gly 
    930                 935                 940                 


Ala Ser Ala Ala Glu Pro Leu Asp Arg Ser Lys Phe Glu Glu Asn Glu 
945                 950                 955                 960 


Asp Ile Val Val Met Glu Thr Lys Leu Lys Ile Leu Glu Ile Leu Gln 
                965                 970                 975     


Phe Ile Leu Asn Val Arg Leu Asp Tyr Arg Ile Ser Tyr Leu Leu Ser 
            980                 985                 990         


Val Phe Lys Lys Glu Phe Val Glu  Val Phe Pro Met Gln  Asp Ser Gly 
        995                 1000                 1005             


Ala Asp  Gly Thr Ala Pro Ala  Phe Asp Ser Thr Thr  Ala Asn Met 
    1010                 1015                 1020             


Asn Leu  Asp Arg Ile Gly Glu  Gln Ala Glu Ala Met  Phe Gly Val 
    1025                 1030                 1035             


Gly Lys  Thr Ser Ser Met Leu  Glu Val Asp Asp Glu  Gly Gly Arg 
    1040                 1045                 1050             


Met Phe  Leu Arg Val Leu Ile  His Leu Thr Met His  Asp Tyr Ala 
    1055                 1060                 1065             


Pro Leu  Val Ser Gly Ala Leu  Gln Leu Leu Phe Lys  His Phe Ser 
    1070                 1075                 1080             


Gln Arg  Gln Glu Ala Met His  Thr Phe Lys Gln Val  Gln Leu Leu 
    1085                 1090                 1095             


Ile Ser  Ala Gln Asp Val Glu  Asn Tyr Lys Val Ile  Lys Ser Glu 
    1100                 1105                 1110             


Leu Asp  Arg Leu Arg Thr Met  Val Glu Lys Ser Glu  Leu Trp Val 
    1115                 1120                 1125             


Asp Lys  Lys Gly Ser Gly Lys  Gly Glu Glu Val Glu  Ala Gly Ala 
    1130                 1135                 1140             


Ala Lys  Asp Lys Lys Glu Arg  Pro Thr Asp Glu Glu  Gly Phe Leu 
    1145                 1150                 1155             


His Pro  Pro Gly Glu Lys Ser  Ser Glu Asn Tyr Gln  Ile Val Lys 
    1160                 1165                 1170             


Gly Ile  Leu Glu Arg Leu Asn  Lys Met Cys Gly Val  Gly Glu Gln 
    1175                 1180                 1185             


Met Arg  Lys Lys Gln Gln Arg  Leu Leu Lys Asn Met  Asp Ala His 
    1190                 1195                 1200             


Lys Val  Met Leu Asp Leu Leu  Gln Ile Pro Tyr Asp  Lys Gly Asp 
    1205                 1210                 1215             


Ala Lys  Met Met Glu Ile Leu  Arg Tyr Thr His Gln  Phe Leu Gln 
    1220                 1225                 1230             


Lys Phe  Cys Ala Gly Asn Pro  Gly Asn Gln Ala Leu  Leu His Lys 
    1235                 1240                 1245             


His Leu  His Leu Phe Leu Thr  Pro Gly Leu Leu Glu  Ala Glu Thr 
    1250                 1255                 1260             


Met Gln  His Ile Phe Leu Asn  Asn Tyr Gln Leu Cys  Ser Glu Ile 
    1265                 1270                 1275             


Ser Glu  Pro Val Leu Gln His  Phe Val His Leu Leu  Ala Thr His 
    1280                 1285                 1290             


Gly Arg  His Val Gln Tyr Leu  Asp Phe Leu His Thr  Val Ile Lys 
    1295                 1300                 1305             


Ala Glu  Gly Lys Tyr Val Lys  Lys Cys Gln Asp Met  Ile Met Thr 
    1310                 1315                 1320             


Glu Leu  Thr Asn Ala Gly Asp  Asp Val Val Val Phe  Tyr Asn Asp 
    1325                 1330                 1335             


Lys Ala  Ser Leu Ala His Leu  Leu Asp Met Met Lys  Ala Ala Arg 
    1340                 1345                 1350             


Asp Gly  Val Glu Asp His Ser  Pro Leu Met Tyr His  Ile Ser Leu 
    1355                 1360                 1365             


Val Asp  Leu Leu Ala Ala Cys  Ala Glu Gly Lys Asn  Val Tyr Thr 
    1370                 1375                 1380             


Glu Ile  Lys Cys Thr Ser Leu  Leu Pro Leu Glu Asp  Val Val Ser 
    1385                 1390                 1395             


Val Val  Thr His Glu Asp Cys  Ile Thr Glu Val Lys  Met Ala Tyr 
    1400                 1405                 1410             


Val Asn  Phe Val Asn His Cys  Tyr Val Asp Thr Glu  Val Glu Met 
    1415                 1420                 1425             


Lys Glu  Ile Tyr Thr Ser Asn  His Ile Trp Thr Leu  Phe Glu Asn 
    1430                 1435                 1440             


Phe Thr  Leu Asp Met Ala Arg  Val Cys Ser Lys Arg  Glu Lys Arg 
    1445                 1450                 1455             


Val Ala  Asp Pro Thr Leu Glu  Lys Tyr Val Leu Ser  Val Val Leu 
    1460                 1465                 1470             


Asp Thr  Ile Asn Ala Phe Phe  Ser Ser Pro Phe Ser  Glu Asn Ser 
    1475                 1480                 1485             


Thr Ser  Leu Gln Thr His Gln  Thr Ile Val Val Gln  Leu Leu Gln 
    1490                 1495                 1500             


Ser Thr  Thr Arg Leu Leu Glu  Cys Pro Trp Leu Gln  Gln Gln His 
    1505                 1510                 1515             


Lys Gly  Ser Val Glu Ala Cys  Ile Arg Thr Leu Ala  Met Val Ala 
    1520                 1525                 1530             


Lys Gly  Arg Ala Ile Leu Leu  Pro Met Asp Leu Asp  Ala His Ile 
    1535                 1540                 1545             


Ser Ser  Met Leu Ser Ser Gly  Ala Ser Cys Ala Ala  Ala Ala Gln 
    1550                 1555                 1560             


Arg Asn  Ala Ser Ser Tyr Lys  Ala Thr Thr Arg Ala  Phe Pro Arg 
    1565                 1570                 1575             


Val Thr  Pro Thr Ala Asn Gln  Trp Asp Tyr Lys Asn  Ile Ile Glu 
    1580                 1585                 1590             


Lys Leu  Gln Asp Ile Ile Thr  Ala Leu Glu Glu Arg  Leu Lys Pro 
    1595                 1600                 1605             


Leu Val  Gln Ala Glu Leu Ser  Val Leu Val Asp Val  Leu His Trp 
    1610                 1615                 1620             


Pro Glu  Leu Leu Phe Leu Glu  Gly Ser Glu Ala Tyr  Gln Arg Cys 
    1625                 1630                 1635             


Glu Ser  Gly Gly Phe Leu Ser  Lys Leu Ile Gln His  Thr Lys Asp 
    1640                 1645                 1650             


Leu Met  Glu Ser Glu Glu Lys  Leu Cys Ile Lys Val  Leu Arg Thr 
    1655                 1660                 1665             


Leu Gln  Gln Met Leu Leu Lys  Lys Thr Lys Tyr Gly  Asp Arg Gly 
    1670                 1675                 1680             


Asn Gln  Leu Arg Lys Met Leu  Leu Gln Asn Tyr Leu  Gln Asn Arg 
    1685                 1690                 1695             


Lys Ser  Thr Ser Arg Gly Asp  Leu Pro Asp Pro Ile  Gly Thr Gly 
    1700                 1705                 1710             


Leu Asp  Pro Asp Trp Ser Ala  Ile Ala Ala Thr Gln  Cys Arg Leu 
    1715                 1720                 1725             


Asp Lys  Glu Gly Ala Thr Lys  Leu Val Cys Asp Leu  Ile Thr Ser 
    1730                 1735                 1740             


Thr Lys  Asn Glu Lys Ile Phe  Gln Glu Ser Ile Gly  Leu Ala Ile 
    1745                 1750                 1755             


His Leu  Leu Asp Gly Gly Asn  Thr Glu Ile Gln Lys  Ser Phe His 
    1760                 1765                 1770             


Asn Leu  Met Met Ser Asp Lys  Lys Ser Glu Arg Phe  Phe Lys Val 
    1775                 1780                 1785             


Leu His  Asp Arg Met Lys Arg  Ala Gln Gln Glu Thr  Lys Ser Thr 
    1790                 1795                 1800             


Val Ala  Val Asn Met Asn Asp  Leu Gly Ser Gln Pro  His Glu Asp 
    1805                 1810                 1815             


Arg Glu  Pro Val Asp Pro Thr  Thr Lys Gly Arg Val  Ala Ser Phe 
    1820                 1825                 1830             


Ser Ile  Pro Gly Ser Ser Ser  Arg Tyr Ser Leu Gly  Pro Ser Leu 
    1835                 1840                 1845             


Arg Arg  Gly His Glu Val Ser  Glu Arg Val Gln Ser  Ser Glu Met 
    1850                 1855                 1860             


Gly Thr  Ser Val Leu Ile Met  Gln Pro Ile Leu Arg  Phe Leu Gln 
    1865                 1870                 1875             


Leu Leu  Cys Glu Asn His Asn  Arg Asp Leu Gln Asn  Phe Leu Arg 
    1880                 1885                 1890             


Cys Gln  Asn Asn Lys Thr Asn  Tyr Asn Leu Val Cys  Glu Thr Leu 
    1895                 1900                 1905             


Gln Phe  Leu Asp Ile Met Cys  Gly Ser Thr Thr Gly  Gly Leu Gly 
    1910                 1915                 1920             


Leu Leu  Gly Leu Tyr Ile Asn  Glu Asp Asn Val Gly  Leu Val Ile 
    1925                 1930                 1935             


Gln Thr  Leu Glu Thr Leu Thr  Glu Tyr Cys Gln Gly  Pro Cys His 
    1940                 1945                 1950             


Glu Asn  Gln Thr Cys Ile Val  Thr His Glu Ser Asn  Gly Ile Asp 
    1955                 1960                 1965             


Ile Ile  Thr Ala Leu Ile Leu  Asn Asp Ile Ser Pro  Leu Cys Lys 
    1970                 1975                 1980             


Tyr Arg  Met Asp Leu Val Leu  Gln Leu Lys Asp Asn  Ala Ser Lys 
    1985                 1990                 1995             


Leu Leu  Leu Ala Leu Met Glu  Ser Arg His Asp Ser  Glu Asn Ala 
    2000                 2005                 2010             


Glu Arg  Ile Leu Ile Ser Leu  Arg Pro Gln Glu Leu  Val Asp Val 
    2015                 2020                 2025             


Ile Lys  Lys Ala Tyr Leu Gln  Glu Glu Glu Arg Glu  Asn Ser Glu 
    2030                 2035                 2040             


Val Ser  Pro Arg Glu Val Gly  His Asn Ile Tyr Ile  Leu Ala Leu 
    2045                 2050                 2055             


Gln Leu  Ser Arg His Asn Lys  Gln Leu Gln His Leu  Leu Lys Pro 
    2060                 2065                 2070             


Val Lys  Arg Ile Gln Glu Glu  Glu Ala Glu Gly Ile  Ser Ser Met 
    2075                 2080                 2085             


Leu Ser  Leu Asn Asn Lys Gln  Leu Ser Gln Met Leu  Lys Ser Ser 
    2090                 2095                 2100             


Ala Pro  Ala Gln Glu Glu Glu  Glu Asp Pro Leu Ala  Tyr Tyr Glu 
    2105                 2110                 2115             


Asn His  Thr Ser Gln Ile Glu  Ile Val Arg Gln Asp  Arg Ser Met 
    2120                 2125                 2130             


Glu Gln  Ile Val Phe Pro Val  Pro Gly Ile Cys Gln  Phe Leu Thr 
    2135                 2140                 2145             


Glu Glu  Thr Lys His Arg Leu  Phe Thr Thr Thr Glu  Gln Asp Glu 
    2150                 2155                 2160             


Gln Gly  Ser Lys Val Ser Asp  Phe Phe Asp Gln Ser  Ser Phe Leu 
    2165                 2170                 2175             


His Asn  Glu Met Glu Trp Gln  Arg Lys Leu Arg Ser  Met Pro Leu 
    2180                 2185                 2190             


Ile Tyr  Trp Phe Ser Arg Arg  Met Thr Leu Trp Gly  Ser Ile Ser 
    2195                 2200                 2205             


Phe Asn  Leu Ala Val Phe Ile  Asn Ile Ile Ile Ala  Phe Phe Tyr 
    2210                 2215                 2220             


Pro Tyr  Met Glu Gly Ala Ser  Thr Gly Val Leu Asp  Ser Pro Leu 
    2225                 2230                 2235             


Ile Ser  Leu Leu Phe Trp Ile  Leu Ile Cys Phe Ser  Ile Ala Ala 
    2240                 2245                 2250             


Leu Phe  Thr Lys Arg Tyr Ser  Ile Arg Pro Leu Ile  Val Ala Leu 
    2255                 2260                 2265             


Ile Leu  Arg Ser Ile Tyr Tyr  Leu Gly Ile Gly Pro  Thr Leu Asn 
    2270                 2275                 2280             


Ile Leu  Gly Ala Leu Asn Leu  Thr Asn Lys Ile Val  Phe Val Val 
    2285                 2290                 2295             


Ser Phe  Val Gly Asn Arg Gly  Thr Phe Ile Arg Gly  Tyr Lys Ala 
    2300                 2305                 2310             


Met Val  Met Asp Met Glu Phe  Leu Tyr His Val Gly  Tyr Ile Leu 
    2315                 2320                 2325             


Thr Ser  Val Leu Gly Leu Phe  Ala His Glu Leu Phe  Tyr Ser Ile 
    2330                 2335                 2340             


Leu Leu  Phe Asp Leu Ile Tyr  Arg Glu Glu Thr Leu  Phe Asn Val 
    2345                 2350                 2355             


Ile Lys  Ser Val Thr Arg Asn  Gly Arg Ser Ile Leu  Leu Thr Ala 
    2360                 2365                 2370             


Leu Leu  Ala Leu Ile Leu Val  Tyr Leu Phe Ser Ile  Val Gly Phe 
    2375                 2380                 2385             


Leu Phe  Leu Lys Asp Asp Phe  Ile Leu Glu Val Asp  Arg Leu Pro 
    2390                 2395                 2400             


Asn Asn  His Ser Thr Ala Ser  Pro Leu Gly Met Pro  His Gly Ala 
    2405                 2410                 2415             


Ala Ala  Phe Val Asp Thr Cys  Ser Gly Asp Lys Met  Asp Cys Val 
    2420                 2425                 2430             


Ser Gly  Leu Ser Val Pro Glu  Val Leu Glu Glu Asp  Arg Glu Leu 
    2435                 2440                 2445             


Asp Ser  Thr Glu Arg Ala Cys  Asp Thr Leu Leu Met  Cys Ile Val 
    2450                 2455                 2460             


Thr Val  Met Asn His Gly Leu  Arg Asn Gly Gly Gly  Val Gly Asp 
    2465                 2470                 2475             


Ile Leu  Arg Lys Pro Ser Lys  Asp Glu Ser Leu Phe  Pro Ala Arg 
    2480                 2485                 2490             


Val Val  Tyr Asp Leu Leu Phe  Phe Phe Ile Val Ile  Ile Ile Val 
    2495                 2500                 2505             


Leu Asn  Leu Ile Phe Gly Val  Ile Ile Asp Thr Phe  Ala Asp Leu 
    2510                 2515                 2520             


Arg Ser  Glu Lys Gln Lys Lys  Glu Glu Ile Leu Lys  Thr Thr Cys 
    2525                 2530                 2535             


Phe Ile  Cys Gly Leu Glu Arg  Asp Lys Phe Asp Asn  Lys Thr Val 
    2540                 2545                 2550             


Ser Phe  Glu Glu His Ile Lys  Leu Glu His Asn Met  Trp Asn Tyr 
    2555                 2560                 2565             


Leu Tyr  Phe Ile Val Leu Val  Arg Val Lys Asn Lys  Thr Asp Tyr 
    2570                 2575                 2580             


Thr Gly  Pro Glu Ser Tyr Val  Ala Gln Met Ile Lys  Asn Lys Asn 
    2585                 2590                 2595             


Leu Asp  Trp Phe Pro Arg Met  Arg Ala Met Ser Leu  Val Ser Asn 
    2600                 2605                 2610             


Glu Gly  Glu Gly Glu Gln Asn  Glu Ile Arg Ile Leu  Gln Asp Lys 
    2615                 2620                 2625             


Leu Asn  Ser Thr Met Lys Leu  Val Ser His Leu Thr  Ala Gln Leu 
    2630                 2635                 2640             


Asn Glu  Leu Lys Glu Gln Met  Thr Glu Gln Arg Lys  Arg Arg Gln 
    2645                 2650                 2655             


Arg Leu  Gly Phe Val Asp Val  Gln Asn Cys Ile Ser  Arg 
    2660                 2665                 2670     


<210>  2586
<211>  1238
<212>  PRT
<213>  Homo sapiens

<400>  2586

Met Arg Ala Gln Gly Arg Gly Arg Leu Pro Arg Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Leu Trp Val Gln Ala Ala Arg Pro Met Gly Tyr Phe Glu Leu 
            20                  25                  30          


Gln Leu Ser Ala Leu Arg Asn Val Asn Gly Glu Leu Leu Ser Gly Ala 
        35                  40                  45              


Cys Cys Asp Gly Asp Gly Arg Thr Thr Arg Ala Gly Gly Cys Gly His 
    50                  55                  60                  


Asp Glu Cys Asp Thr Tyr Val Arg Val Cys Leu Lys Glu Tyr Gln Ala 
65                  70                  75                  80  


Lys Val Thr Pro Thr Gly Pro Cys Ser Tyr Gly His Gly Ala Thr Pro 
                85                  90                  95      


Val Leu Gly Gly Asn Ser Phe Tyr Leu Pro Pro Ala Gly Ala Ala Gly 
            100                 105                 110         


Asp Arg Ala Arg Ala Arg Ala Arg Ala Gly Gly Asp Gln Asp Pro Gly 
        115                 120                 125             


Leu Val Val Ile Pro Phe Gln Phe Ala Trp Pro Arg Ser Phe Thr Leu 
    130                 135                 140                 


Ile Val Glu Ala Trp Asp Trp Asp Asn Asp Thr Thr Pro Asn Glu Glu 
145                 150                 155                 160 


Leu Leu Ile Glu Arg Val Ser His Ala Gly Met Ile Asn Pro Glu Asp 
                165                 170                 175     


Arg Trp Lys Ser Leu His Phe Ser Gly His Val Ala His Leu Glu Leu 
            180                 185                 190         


Gln Ile Arg Val Arg Cys Asp Glu Asn Tyr Tyr Ser Ala Thr Cys Asn 
        195                 200                 205             


Lys Phe Cys Arg Pro Arg Asn Asp Phe Phe Gly His Tyr Thr Cys Asp 
    210                 215                 220                 


Gln Tyr Gly Asn Lys Ala Cys Met Asp Gly Trp Met Gly Lys Glu Cys 
225                 230                 235                 240 


Lys Glu Ala Val Cys Lys Gln Gly Cys Asn Leu Leu His Gly Gly Cys 
                245                 250                 255     


Thr Val Pro Gly Glu Cys Arg Cys Ser Tyr Gly Trp Gln Gly Arg Phe 
            260                 265                 270         


Cys Asp Glu Cys Val Pro Tyr Pro Gly Cys Val His Gly Ser Cys Val 
        275                 280                 285             


Glu Pro Trp Gln Cys Asn Cys Glu Thr Asn Trp Gly Gly Leu Leu Cys 
    290                 295                 300                 


Asp Lys Asp Leu Asn Tyr Cys Gly Ser His His Pro Cys Thr Asn Gly 
305                 310                 315                 320 


Gly Thr Cys Ile Asn Ala Glu Pro Asp Gln Tyr Arg Cys Thr Cys Pro 
                325                 330                 335     


Asp Gly Tyr Ser Gly Arg Asn Cys Glu Lys Ala Glu His Ala Cys Thr 
            340                 345                 350         


Ser Asn Pro Cys Ala Asn Gly Gly Ser Cys His Glu Val Pro Ser Gly 
        355                 360                 365             


Phe Glu Cys His Cys Pro Ser Gly Trp Ser Gly Pro Thr Cys Ala Leu 
    370                 375                 380                 


Asp Ile Asp Glu Cys Ala Ser Asn Pro Cys Ala Ala Gly Gly Thr Cys 
385                 390                 395                 400 


Val Asp Gln Val Asp Gly Phe Glu Cys Ile Cys Pro Glu Gln Trp Val 
                405                 410                 415     


Gly Ala Thr Cys Gln Leu Asp Ala Asn Glu Cys Glu Gly Lys Pro Cys 
            420                 425                 430         


Leu Asn Ala Phe Ser Cys Lys Asn Leu Ile Gly Gly Tyr Tyr Cys Asp 
        435                 440                 445             


Cys Ile Pro Gly Trp Lys Gly Ile Asn Cys His Ile Asn Val Asn Asp 
    450                 455                 460                 


Cys Arg Gly Gln Cys Gln His Gly Gly Thr Cys Lys Asp Leu Val Asn 
465                 470                 475                 480 


Gly Tyr Gln Cys Val Cys Pro Arg Gly Phe Gly Gly Arg His Cys Glu 
                485                 490                 495     


Leu Glu Arg Asp Glu Cys Ala Ser Ser Pro Cys His Ser Gly Gly Leu 
            500                 505                 510         


Cys Glu Asp Leu Ala Asp Gly Phe His Cys His Cys Pro Gln Gly Phe 
        515                 520                 525             


Ser Gly Pro Leu Cys Glu Val Asp Val Asp Leu Cys Glu Pro Ser Pro 
    530                 535                 540                 


Cys Arg Asn Gly Ala Arg Cys Tyr Asn Leu Glu Gly Asp Tyr Tyr Cys 
545                 550                 555                 560 


Ala Cys Pro Asp Asp Phe Gly Gly Lys Asn Cys Ser Val Pro Arg Glu 
                565                 570                 575     


Pro Cys Pro Gly Gly Ala Cys Arg Val Ile Asp Gly Cys Gly Ser Asp 
            580                 585                 590         


Ala Gly Pro Gly Met Pro Gly Thr Ala Ala Ser Gly Val Cys Gly Pro 
        595                 600                 605             


His Gly Arg Cys Val Ser Gln Pro Gly Gly Asn Phe Ser Cys Ile Cys 
    610                 615                 620                 


Asp Ser Gly Phe Thr Gly Thr Tyr Cys His Glu Asn Ile Asp Asp Cys 
625                 630                 635                 640 


Leu Gly Gln Pro Cys Arg Asn Gly Gly Thr Cys Ile Asp Glu Val Asp 
                645                 650                 655     


Ala Phe Arg Cys Phe Cys Pro Ser Gly Trp Glu Gly Glu Leu Cys Asp 
            660                 665                 670         


Thr Asn Pro Asn Asp Cys Leu Pro Asp Pro Cys His Ser Arg Gly Arg 
        675                 680                 685             


Cys Tyr Asp Leu Val Asn Asp Phe Tyr Cys Ala Cys Asp Asp Gly Trp 
    690                 695                 700                 


Lys Gly Lys Thr Cys His Ser Arg Glu Phe Gln Cys Asp Ala Tyr Thr 
705                 710                 715                 720 


Cys Ser Asn Gly Gly Thr Cys Tyr Asp Ser Gly Asp Thr Phe Arg Cys 
                725                 730                 735     


Ala Cys Pro Pro Gly Trp Lys Gly Ser Thr Cys Ala Val Ala Lys Asn 
            740                 745                 750         


Ser Ser Cys Leu Pro Asn Pro Cys Val Asn Gly Gly Thr Cys Val Gly 
        755                 760                 765             


Ser Gly Ala Ser Phe Ser Cys Ile Cys Arg Asp Gly Trp Glu Gly Arg 
    770                 775                 780                 


Thr Cys Thr His Asn Thr Asn Asp Cys Asn Pro Leu Pro Cys Tyr Asn 
785                 790                 795                 800 


Gly Gly Ile Cys Val Asp Gly Val Asn Trp Phe Arg Cys Glu Cys Ala 
                805                 810                 815     


Pro Gly Phe Ala Gly Pro Asp Cys Arg Ile Asn Ile Asp Glu Cys Gln 
            820                 825                 830         


Ser Ser Pro Cys Ala Tyr Gly Ala Thr Cys Val Asp Glu Ile Asn Gly 
        835                 840                 845             


Tyr Arg Cys Ser Cys Pro Pro Gly Arg Ala Gly Pro Arg Cys Gln Glu 
    850                 855                 860                 


Val Ile Gly Phe Gly Arg Ser Cys Trp Ser Arg Gly Thr Pro Phe Pro 
865                 870                 875                 880 


His Gly Ser Ser Trp Val Glu Asp Cys Asn Ser Cys Arg Cys Leu Asp 
                885                 890                 895     


Gly Arg Arg Asp Cys Ser Lys Val Trp Cys Gly Trp Lys Pro Cys Leu 
            900                 905                 910         


Leu Ala Gly Gln Pro Glu Ala Leu Ser Ala Gln Cys Pro Leu Gly Gln 
        915                 920                 925             


Arg Cys Leu Glu Lys Ala Pro Gly Gln Cys Leu Arg Pro Pro Cys Glu 
    930                 935                 940                 


Ala Trp Gly Glu Cys Gly Ala Glu Glu Pro Pro Ser Thr Pro Cys Leu 
945                 950                 955                 960 


Pro Arg Ser Gly His Leu Asp Asn Asn Cys Ala Arg Leu Thr Leu His 
                965                 970                 975     


Phe Asn Arg Asp His Val Pro Gln Gly Thr Thr Val Gly Ala Ile Cys 
            980                 985                 990         


Ser Gly Ile Arg Ser Leu Pro Ala  Thr Arg Ala Val Ala  Arg Asp Arg 
        995                 1000                 1005             


Leu Leu  Val Leu Leu Cys Asp  Arg Ala Ser Ser Gly  Ala Ser Ala 
    1010                 1015                 1020             


Val Glu  Val Ala Val Ser Phe  Ser Pro Ala Arg Asp  Leu Pro Asp 
    1025                 1030                 1035             


Ser Ser  Leu Ile Gln Gly Ala  Ala His Ala Ile Val  Ala Ala Ile 
    1040                 1045                 1050             


Thr Gln  Arg Gly Asn Ser Ser  Leu Leu Leu Ala Val  Thr Glu Val 
    1055                 1060                 1065             


Lys Val  Glu Thr Val Val Thr  Gly Gly Ser Ser Thr  Gly Leu Leu 
    1070                 1075                 1080             


Val Pro  Val Leu Cys Gly Ala  Phe Ser Val Leu Trp  Leu Ala Cys 
    1085                 1090                 1095             


Val Val  Leu Cys Val Trp Trp  Thr Arg Lys Arg Arg  Lys Glu Arg 
    1100                 1105                 1110             


Glu Arg  Ser Arg Leu Pro Arg  Glu Glu Ser Ala Asn  Asn Gln Trp 
    1115                 1120                 1125             


Ala Pro  Leu Asn Pro Ile Arg  Asn Pro Ile Glu Arg  Pro Gly Gly 
    1130                 1135                 1140             


His Lys  Asp Val Leu Tyr Gln  Cys Lys Asn Phe Thr  Pro Pro Pro 
    1145                 1150                 1155             


Arg Arg  Ala Asp Glu Ala Leu  Pro Gly Pro Ala Gly  His Ala Ala 
    1160                 1165                 1170             


Val Arg  Glu Asp Glu Glu Asp  Glu Asp Leu Gly Arg  Gly Glu Glu 
    1175                 1180                 1185             


Asp Ser  Leu Glu Ala Glu Lys  Phe Leu Ser His Lys  Phe Thr Lys 
    1190                 1195                 1200             


Asp Pro  Gly Arg Ser Pro Gly  Arg Pro Ala His Trp  Ala Ser Gly 
    1205                 1210                 1215             


Pro Lys  Val Asp Asn Arg Ala  Val Arg Ser Ile Asn  Glu Ala Arg 
    1220                 1225                 1230             


Tyr Ala  Gly Lys Glu 
    1235             


<210>  2587
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  2587

Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe 
1               5                   10                  15      


Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val 
            20                  25                  30          


Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser 
        35                  40                  45              


Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala 
    50                  55                  60                  


Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu 
65                  70                  75                  80  


Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu 
                85                  90                  95      


Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys 
            100                 105                 110         


Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr 
        115                 120                 125             


Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln 
    130                 135                 140                 


Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp 
145                 150                 155                 160 


Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys 
                165                 170                 175     


Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe 
            180                 185                 190         


Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp 
        195                 200                 205             


Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu 
    210                 215                 220                 


Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile 
225                 230                 235                 240 


Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val 
                245                 250                 255     


His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr 
            260                 265         


<210>  2588
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  2588

Met Asp Glu Arg Leu Ser Leu Leu Arg Ser Pro Pro Pro Pro Ser Ala 
1               5                   10                  15      


Arg His Arg Ala His Pro Pro Gln Arg Pro Ala Ser Ser Gly Gly Ala 
            20                  25                  30          


His Thr Leu Val Asn His Gly Tyr Ala Glu Pro Ala Ala Gly Arg Glu 
        35                  40                  45              


Leu Pro Pro Asp Met Thr Val Val Pro Gly Asp His Leu Leu Glu Pro 
    50                  55                  60                  


Glu Val Ala Asp Gly Gly Gly Ala Pro Pro Gln Gly Gly Cys Gly Gly 
65                  70                  75                  80  


Gly Gly Cys Asp Arg Tyr Glu Pro Leu Pro Pro Ser Leu Pro Ala Ala 
                85                  90                  95      


Gly Glu Gln Asp Cys Cys Gly Glu Arg Val Val Ile Asn Ile Ser Gly 
            100                 105                 110         


Leu Arg Phe Glu Thr Gln Leu Lys Thr Leu Cys Gln Phe Pro Glu Thr 
        115                 120                 125             


Leu Leu Gly Asp Pro Lys Arg Arg Met Arg Tyr Phe Asp Pro Leu Arg 
    130                 135                 140                 


Asn Glu Tyr Phe Phe Asp Arg Asn Arg Pro Ser Phe Asp Ala Ile Leu 
145                 150                 155                 160 


Tyr Tyr Tyr Gln Ser Gly Gly Arg Ile Arg Arg Pro Val Asn Val Pro 
                165                 170                 175     


Ile Asp Ile Phe Ser Glu Glu Ile Arg Phe Tyr Gln Leu Gly Glu Glu 
            180                 185                 190         


Ala Met Glu Lys Phe Arg Glu Asp Glu Gly Phe Leu Arg Glu Glu Glu 
        195                 200                 205             


Arg Pro Leu Pro Arg Arg Asp Phe Gln Arg Gln Val Trp Leu Leu Phe 
    210                 215                 220                 


Glu Tyr Pro Glu Ser Ser Gly Pro Ala Arg Gly Ile Ala Ile Val Ser 
225                 230                 235                 240 


Val Leu Val Ile Leu Ile Ser Ile Val Ile Phe Cys Leu Glu Thr Leu 
                245                 250                 255     


Pro Glu Phe Arg Asp Glu Lys Asp Tyr Pro Ala Ser Thr Ser Gln Asp 
            260                 265                 270         


Ser Phe Glu Ala Ala Gly Asn Ser Thr Ser Gly Ser Arg Ala Gly Ala 
        275                 280                 285             


Ser Ser Phe Ser Asp Pro Phe Phe Val Val Glu Thr Leu Cys Ile Ile 
    290                 295                 300                 


Trp Phe Ser Phe Glu Leu Leu Val Arg Phe Phe Ala Cys Pro Ser Lys 
305                 310                 315                 320 


Ala Thr Phe Ser Arg Asn Ile Met Asn Leu Ile Asp Ile Val Ala Ile 
                325                 330                 335     


Ile Pro Tyr Phe Ile Thr Leu Gly Thr Glu Leu Ala Glu Arg Gln Gly 
            340                 345                 350         


Asn Gly Gln Gln Ala Met Ser Leu Ala Ile Leu Arg Val Ile Arg Leu 
        355                 360                 365             


Val Arg Val Phe Arg Ile Phe Lys Leu Ser Arg His Ser Lys Gly Leu 
    370                 375                 380                 


Gln Ile Leu Gly Gln Thr Leu Lys Ala Ser Met Arg Glu Leu Gly Leu 
385                 390                 395                 400 


Leu Ile Phe Phe Leu Phe Ile Gly Val Ile Leu Phe Ser Ser Ala Val 
                405                 410                 415     


Tyr Phe Ala Glu Ala Asp Asp Pro Thr Ser Gly Phe Ser Ser Ile Pro 
            420                 425                 430         


Asp Ala Phe Trp Trp Ala Val Val Thr Met Thr Thr Val Gly Tyr Gly 
        435                 440                 445             


Asp Met His Pro Val Thr Ile Gly Gly Lys Ile Val Gly Ser Leu Cys 
    450                 455                 460                 


Ala Ile Ala Gly Val Leu Thr Ile Ala Leu Pro Val Pro Val Ile Val 
465                 470                 475                 480 


Ser Asn Phe Asn Tyr Phe Tyr His Arg Glu Thr Glu Gly Glu Glu Gln 
                485                 490                 495     


Ser Gln Tyr Met His Val Gly Ser Cys Gln His Leu Ser Ser Ser Ala 
            500                 505                 510         


Glu Glu Leu Arg Lys Ala Arg Ser Asn Ser Thr Leu Ser Lys Ser Glu 
        515                 520                 525             


Tyr Met Val Ile Glu Glu Gly Gly Met Asn His Ser Ala Phe Pro Gln 
    530                 535                 540                 


Thr Pro Phe Lys Thr Gly Asn Ser Thr Ala Thr Cys Thr Thr Asn Asn 
545                 550                 555                 560 


Asn Pro Asn Ser Cys Val Asn Ile Lys Lys Ile Phe Thr Asp Val 
                565                 570                 575 


<210>  2589
<211>  653
<212>  PRT
<213>  Homo sapiens

<400>  2589

Met Glu Val Ala Met Val Ser Ala Glu Ser Ser Gly Cys Asn Ser His 
1               5                   10                  15      


Met Pro Tyr Gly Tyr Ala Ala Gln Ala Arg Ala Arg Glu Arg Glu Arg 
            20                  25                  30          


Leu Ala His Ser Arg Ala Ala Ala Ala Ala Ala Val Ala Ala Ala Thr 
        35                  40                  45              


Ala Ala Val Glu Gly Ser Gly Gly Ser Gly Gly Gly Ser His His His 
    50                  55                  60                  


His Gln Ser Arg Gly Ala Cys Thr Ser His Asp Pro Gln Ser Ser Arg 
65                  70                  75                  80  


Gly Ser Arg Arg Arg Arg Arg Gln Arg Ser Glu Lys Lys Lys Ala His 
                85                  90                  95      


Tyr Arg Gln Ser Ser Phe Pro His Cys Ser Asp Leu Met Pro Ser Gly 
            100                 105                 110         


Ser Glu Glu Lys Ile Leu Arg Glu Leu Ser Glu Glu Glu Glu Asp Glu 
        115                 120                 125             


Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Arg Phe Tyr Tyr Ser Glu 
    130                 135                 140                 


Asp Asp His Gly Asp Glu Cys Ser Tyr Thr Asp Leu Leu Pro Gln Asp 
145                 150                 155                 160 


Glu Gly Gly Gly Gly Tyr Ser Ser Val Arg Tyr Ser Asp Cys Cys Glu 
                165                 170                 175     


Arg Val Val Ile Asn Val Ser Gly Leu Arg Phe Glu Thr Gln Met Lys 
            180                 185                 190         


Thr Leu Ala Gln Phe Pro Glu Thr Leu Leu Gly Asp Pro Glu Lys Arg 
        195                 200                 205             


Thr Gln Tyr Phe Asp Pro Leu Arg Asn Glu Tyr Phe Phe Asp Arg Asn 
    210                 215                 220                 


Arg Pro Ser Phe Asp Ala Ile Leu Tyr Tyr Tyr Gln Ser Gly Gly Arg 
225                 230                 235                 240 


Leu Lys Arg Pro Val Asn Val Pro Phe Asp Ile Phe Thr Glu Glu Val 
                245                 250                 255     


Lys Phe Tyr Gln Leu Gly Glu Glu Ala Leu Leu Lys Phe Arg Glu Asp 
            260                 265                 270         


Glu Gly Phe Val Arg Glu Glu Glu Asp Arg Ala Leu Pro Glu Asn Glu 
        275                 280                 285             


Phe Lys Lys Gln Ile Trp Leu Leu Phe Glu Tyr Pro Glu Ser Ser Ser 
    290                 295                 300                 


Pro Ala Arg Gly Ile Ala Ile Val Ser Val Leu Val Ile Leu Ile Ser 
305                 310                 315                 320 


Ile Val Ile Phe Cys Leu Glu Thr Leu Pro Glu Phe Arg Asp Asp Arg 
                325                 330                 335     


Asp Leu Val Met Ala Leu Ser Ala Gly Gly His Gly Gly Leu Leu Asn 
            340                 345                 350         


Asp Thr Ser Ala Pro His Leu Glu Asn Ser Gly His Thr Ile Phe Asn 
        355                 360                 365             


Asp Pro Phe Phe Ile Val Glu Thr Val Cys Ile Val Trp Phe Ser Phe 
    370                 375                 380                 


Glu Phe Val Val Arg Cys Phe Ala Cys Pro Ser Gln Ala Leu Phe Phe 
385                 390                 395                 400 


Lys Asn Ile Met Asn Ile Ile Asp Ile Val Ser Ile Leu Pro Tyr Phe 
                405                 410                 415     


Ile Thr Leu Gly Thr Asp Leu Ala Gln Gln Gln Gly Gly Gly Asn Gly 
            420                 425                 430         


Gln Gln Gln Gln Ala Met Ser Phe Ala Ile Leu Arg Ile Ile Arg Leu 
        435                 440                 445             


Val Arg Val Phe Arg Ile Phe Lys Leu Ser Arg His Ser Lys Gly Leu 
    450                 455                 460                 


Gln Ile Leu Gly His Thr Leu Arg Ala Ser Met Arg Glu Leu Gly Leu 
465                 470                 475                 480 


Leu Ile Phe Phe Leu Phe Ile Gly Val Ile Leu Phe Ser Ser Ala Val 
                485                 490                 495     


Tyr Phe Ala Glu Ala Asp Glu Pro Thr Thr His Phe Gln Ser Ile Pro 
            500                 505                 510         


Asp Ala Phe Trp Trp Ala Val Val Thr Met Thr Thr Val Gly Tyr Gly 
        515                 520                 525             


Asp Met Lys Pro Ile Thr Val Gly Gly Lys Ile Val Gly Ser Leu Cys 
    530                 535                 540                 


Ala Ile Ala Gly Val Leu Thr Ile Ala Leu Pro Val Pro Val Ile Val 
545                 550                 555                 560 


Ser Asn Phe Asn Tyr Phe Tyr His Arg Glu Thr Glu Asn Glu Glu Gln 
                565                 570                 575     


Thr Gln Leu Thr Gln Asn Ala Val Ser Cys Pro Tyr Leu Pro Ser Asn 
            580                 585                 590         


Leu Leu Lys Lys Phe Arg Ser Ser Thr Ser Ser Ser Leu Gly Asp Lys 
        595                 600                 605             


Ser Glu Tyr Leu Glu Met Glu Glu Gly Val Lys Glu Ser Leu Cys Ala 
    610                 615                 620                 


Lys Glu Glu Lys Cys Gln Gly Lys Gly Asp Asp Ser Glu Thr Asp Lys 
625                 630                 635                 640 


Asn Asn Cys Ser Asn Ala Lys Ala Val Glu Thr Asp Val 
                645                 650             


<210>  2590
<211>  613
<212>  PRT
<213>  Homo sapiens

<400>  2590

Met Glu Ile Ala Leu Val Pro Leu Glu Asn Gly Gly Ala Met Thr Val 
1               5                   10                  15      


Arg Gly Gly Asp Glu Ala Arg Ala Gly Cys Gly Gln Ala Thr Gly Gly 
            20                  25                  30          


Glu Leu Gln Cys Pro Pro Thr Ala Gly Leu Ser Asp Gly Pro Lys Glu 
        35                  40                  45              


Pro Ala Pro Lys Gly Arg Gly Ala Gln Arg Asp Ala Asp Ser Gly Val 
    50                  55                  60                  


Arg Pro Leu Pro Pro Leu Pro Asp Pro Gly Val Arg Pro Leu Pro Pro 
65                  70                  75                  80  


Leu Pro Glu Glu Leu Pro Arg Pro Arg Arg Pro Pro Pro Glu Asp Glu 
                85                  90                  95      


Glu Glu Glu Gly Asp Pro Gly Leu Gly Thr Val Glu Asp Gln Ala Leu 
            100                 105                 110         


Gly Thr Ala Ser Leu His His Gln Arg Val His Ile Asn Ile Ser Gly 
        115                 120                 125             


Leu Arg Phe Glu Thr Gln Leu Gly Thr Leu Ala Gln Phe Pro Asn Thr 
    130                 135                 140                 


Leu Leu Gly Asp Pro Ala Lys Arg Leu Arg Tyr Phe Asp Pro Leu Arg 
145                 150                 155                 160 


Asn Glu Tyr Phe Phe Asp Arg Asn Arg Pro Ser Phe Asp Gly Ile Leu 
                165                 170                 175     


Tyr Tyr Tyr Gln Ser Gly Gly Arg Leu Arg Arg Pro Val Asn Val Ser 
            180                 185                 190         


Leu Asp Val Phe Ala Asp Glu Ile Arg Phe Tyr Gln Leu Gly Asp Glu 
        195                 200                 205             


Ala Met Glu Arg Phe Arg Glu Asp Glu Gly Phe Ile Lys Glu Glu Glu 
    210                 215                 220                 


Lys Pro Leu Pro Arg Asn Glu Phe Gln Arg Gln Val Trp Leu Ile Phe 
225                 230                 235                 240 


Glu Tyr Pro Glu Ser Ser Gly Ser Ala Arg Ala Ile Ala Ile Val Ser 
                245                 250                 255     


Val Leu Val Ile Leu Ile Ser Ile Ile Thr Phe Cys Leu Glu Thr Leu 
            260                 265                 270         


Pro Glu Phe Arg Asp Glu Arg Glu Leu Leu Arg His Pro Pro Ala Pro 
        275                 280                 285             


His Gln Pro Pro Ala Pro Ala Pro Gly Ala Asn Gly Ser Gly Val Met 
    290                 295                 300                 


Ala Pro Pro Ser Gly Pro Thr Val Ala Pro Leu Leu Pro Arg Thr Leu 
305                 310                 315                 320 


Ala Asp Pro Phe Phe Ile Val Glu Thr Thr Cys Val Ile Trp Phe Thr 
                325                 330                 335     


Phe Glu Leu Leu Val Arg Phe Phe Ala Cys Pro Ser Lys Ala Gly Phe 
            340                 345                 350         


Ser Arg Asn Ile Met Asn Ile Ile Asp Val Val Ala Ile Phe Pro Tyr 
        355                 360                 365             


Phe Ile Thr Leu Gly Thr Glu Leu Ala Glu Gln Gln Pro Gly Gly Gly 
    370                 375                 380                 


Gly Gly Gly Gln Asn Gly Gln Gln Ala Met Ser Leu Ala Ile Leu Arg 
385                 390                 395                 400 


Val Ile Arg Leu Val Arg Val Phe Arg Ile Phe Lys Leu Ser Arg His 
                405                 410                 415     


Ser Lys Gly Leu Gln Ile Leu Gly Lys Thr Leu Gln Ala Ser Met Arg 
            420                 425                 430         


Glu Leu Gly Leu Leu Ile Phe Phe Leu Phe Ile Gly Val Ile Leu Phe 
        435                 440                 445             


Ser Ser Ala Val Tyr Phe Ala Glu Ala Asp Asn Gln Gly Thr His Phe 
    450                 455                 460                 


Ser Ser Ile Pro Asp Ala Phe Trp Trp Ala Val Val Thr Met Thr Thr 
465                 470                 475                 480 


Val Gly Tyr Gly Asp Met Arg Pro Ile Thr Val Gly Gly Lys Ile Val 
                485                 490                 495     


Gly Ser Leu Cys Ala Ile Ala Gly Val Leu Thr Ile Ala Leu Pro Val 
            500                 505                 510         


Pro Val Ile Val Ser Asn Phe Asn Tyr Phe Tyr His Arg Glu Thr Asp 
        515                 520                 525             


His Glu Glu Pro Ala Val Leu Lys Glu Glu Gln Gly Thr Gln Ser Gln 
    530                 535                 540                 


Gly Pro Gly Leu Asp Arg Gly Val Gln Arg Lys Val Ser Gly Ser Arg 
545                 550                 555                 560 


Gly Ser Phe Cys Lys Ala Gly Gly Thr Leu Glu Asn Ala Asp Ser Ala 
                565                 570                 575     


Arg Arg Gly Ser Cys Pro Leu Glu Lys Cys Asn Val Lys Ala Lys Ser 
            580                 585                 590         


Asn Val Asp Leu Arg Arg Ser Leu Tyr Ala Leu Cys Leu Asp Thr Ser 
        595                 600                 605             


Arg Glu Thr Asp Leu 
    610             


<210>  2591
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  2591

Met Arg Ser Glu Lys Ser Leu Thr Leu Ala Ala Pro Gly Glu Val Arg 
1               5                   10                  15      


Gly Pro Glu Gly Glu Gln Gln Asp Ala Gly Asp Phe Pro Glu Ala Gly 
            20                  25                  30          


Gly Gly Gly Gly Cys Cys Ser Ser Glu Arg Leu Val Ile Asn Ile Ser 
        35                  40                  45              


Gly Leu Arg Phe Glu Thr Gln Leu Arg Thr Leu Ser Leu Phe Pro Asp 
    50                  55                  60                  


Thr Leu Leu Gly Asp Pro Gly Arg Arg Val Arg Phe Phe Asp Pro Leu 
65                  70                  75                  80  


Arg Asn Glu Tyr Phe Phe Asp Arg Asn Arg Pro Ser Phe Asp Ala Ile 
                85                  90                  95      


Leu Tyr Tyr Tyr Gln Ser Gly Gly Arg Leu Arg Arg Pro Val Asn Val 
            100                 105                 110         


Pro Leu Asp Ile Phe Leu Glu Glu Ile Arg Phe Tyr Gln Leu Gly Asp 
        115                 120                 125             


Glu Ala Leu Ala Ala Phe Arg Glu Asp Glu Gly Cys Leu Pro Glu Gly 
    130                 135                 140                 


Gly Glu Asp Glu Lys Pro Leu Pro Ser Gln Pro Phe Gln Arg Gln Val 
145                 150                 155                 160 


Trp Leu Leu Phe Glu Tyr Pro Glu Ser Ser Gly Pro Ala Arg Gly Ile 
                165                 170                 175     


Ala Ile Val Ser Val Leu Val Ile Leu Ile Ser Ile Val Ile Phe Cys 
            180                 185                 190         


Leu Glu Thr Leu Pro Gln Phe Arg Val Asp Gly Arg Gly Gly Asn Asn 
        195                 200                 205             


Gly Gly Val Ser Arg Val Ser Pro Val Ser Arg Gly Ser Gln Glu Glu 
    210                 215                 220                 


Glu Glu Asp Glu Asp Asp Ser Tyr Thr Phe His His Gly Ile Thr Pro 
225                 230                 235                 240 


Gly Glu Met Gly Thr Gly Gly Ser Ser Ser Leu Ser Thr Leu Gly Gly 
                245                 250                 255     


Ser Phe Phe Thr Asp Pro Phe Phe Leu Val Glu Thr Leu Cys Ile Val 
            260                 265                 270         


Trp Phe Thr Phe Glu Leu Leu Val Arg Phe Ser Ala Cys Pro Ser Lys 
        275                 280                 285             


Pro Ala Phe Phe Arg Asn Ile Met Asn Ile Ile Asp Leu Val Ala Ile 
    290                 295                 300                 


Phe Pro Tyr Phe Ile Thr Leu Gly Thr Glu Leu Val Gln Gln Gln Glu 
305                 310                 315                 320 


Gln Gln Pro Ala Ser Gly Gly Gly Gly Gln Asn Gly Gln Gln Ala Met 
                325                 330                 335     


Ser Leu Ala Ile Leu Arg Val Ile Arg Leu Val Arg Val Phe Arg Ile 
            340                 345                 350         


Phe Lys Leu Ser Arg His Ser Lys Gly Leu Gln Ile Leu Gly Lys Thr 
        355                 360                 365             


Leu Gln Ala Ser Met Arg Glu Leu Gly Leu Leu Ile Phe Phe Leu Phe 
    370                 375                 380                 


Ile Gly Val Ile Leu Phe Ser Ser Ala Val Tyr Phe Ala Glu Ala Asp 
385                 390                 395                 400 


Asp Asp Asp Ser Leu Phe Pro Ser Ile Pro Asp Ala Phe Trp Trp Ala 
                405                 410                 415     


Val Val Thr Met Thr Thr Val Gly Tyr Gly Asp Met Tyr Pro Met Thr 
            420                 425                 430         


Val Gly Gly Lys Ile Val Gly Ser Leu Cys Ala Ile Ala Gly Val Leu 
        435                 440                 445             


Thr Ile Ala Leu Pro Val Pro Val Ile Val Ser Asn Phe Asn Tyr Phe 
    450                 455                 460                 


Tyr His Arg Glu Thr Glu Gln Glu Glu Gln Gly Gln Tyr Thr His Val 
465                 470                 475                 480 


Thr Cys Gly Gln Pro Ala Pro Asp Leu Arg Ala Thr Asp Asn Gly Leu 
                485                 490                 495     


Gly Lys Pro Asp Phe Pro Glu Ala Asn Arg Glu Arg Arg Pro Ser Tyr 
            500                 505                 510         


Leu Pro Thr Pro His Arg Ala Tyr Ala Glu Lys Arg Met Leu Thr Glu 
        515                 520                 525             


Val 
    


<210>  2592
<211>  494
<212>  PRT
<213>  Homo sapiens

<400>  2592

Met Asp Gly Ser Gly Glu Arg Ser Leu Pro Glu Pro Gly Ser Gln Ser 
1               5                   10                  15      


Ser Ala Ala Ser Asp Asp Ile Glu Ile Val Val Asn Val Gly Gly Val 
            20                  25                  30          


Arg Gln Val Leu Tyr Gly Asp Leu Leu Ser Gln Tyr Pro Glu Thr Arg 
        35                  40                  45              


Leu Ala Glu Leu Ile Asn Cys Leu Ala Gly Gly Tyr Asp Thr Ile Phe 
    50                  55                  60                  


Ser Leu Cys Asp Asp Tyr Asp Pro Gly Lys Arg Glu Phe Tyr Phe Asp 
65                  70                  75                  80  


Arg Asp Pro Asp Ala Phe Lys Cys Val Ile Glu Val Tyr Tyr Phe Gly 
                85                  90                  95      


Glu Val His Met Lys Lys Gly Ile Cys Pro Ile Cys Phe Lys Asn Glu 
            100                 105                 110         


Met Asp Phe Trp Lys Val Asp Leu Lys Phe Leu Asp Asp Cys Cys Lys 
        115                 120                 125             


Ser His Leu Ser Glu Lys Arg Glu Glu Leu Glu Glu Ile Ala Arg Arg 
    130                 135                 140                 


Val Gln Leu Ile Leu Asp Asp Leu Gly Val Asp Ala Ala Glu Gly Arg 
145                 150                 155                 160 


Trp Arg Arg Cys Gln Lys Cys Val Trp Lys Phe Leu Glu Lys Pro Glu 
                165                 170                 175     


Ser Ser Cys Pro Ala Arg Val Val Ala Val Leu Ser Phe Leu Leu Ile 
            180                 185                 190         


Leu Val Ser Ser Val Val Met Cys Met Gly Thr Ile Pro Glu Leu Gln 
        195                 200                 205             


Val Leu Asp Ala Glu Gly Asn Arg Val Glu His Pro Thr Leu Glu Asn 
    210                 215                 220                 


Val Glu Thr Ala Cys Ile Gly Trp Phe Thr Leu Glu Tyr Leu Leu Arg 
225                 230                 235                 240 


Leu Phe Ser Ser Pro Asn Lys Leu His Phe Ala Leu Ser Phe Met Asn 
                245                 250                 255     


Ile Val Asp Val Leu Ala Ile Leu Pro Phe Tyr Val Ser Leu Thr Leu 
            260                 265                 270         


Thr His Leu Gly Ala Arg Met Met Glu Leu Thr Asn Val Gln Gln Ala 
        275                 280                 285             


Val Gln Ala Leu Arg Ile Met Arg Ile Ala Arg Ile Phe Lys Leu Ala 
    290                 295                 300                 


Arg His Ser Ser Gly Leu Gln Thr Leu Thr Tyr Ala Leu Lys Arg Ser 
305                 310                 315                 320 


Phe Lys Glu Leu Gly Leu Leu Leu Met Tyr Leu Ala Val Gly Ile Phe 
                325                 330                 335     


Val Phe Ser Ala Leu Gly Tyr Thr Met Glu Gln Ser His Pro Glu Thr 
            340                 345                 350         


Leu Phe Lys Ser Ile Pro Gln Ser Phe Trp Trp Ala Ile Ile Thr Met 
        355                 360                 365             


Thr Thr Val Gly Tyr Gly Asp Ile Tyr Pro Lys Thr Thr Leu Gly Lys 
    370                 375                 380                 


Leu Asn Ala Ala Ile Ser Phe Leu Cys Gly Val Ile Ala Ile Ala Leu 
385                 390                 395                 400 


Pro Ile His Pro Ile Ile Asn Asn Phe Val Arg Tyr Tyr Asn Lys Gln 
                405                 410                 415     


Arg Val Leu Glu Thr Ala Ala Lys His Glu Leu Glu Leu Met Glu Leu 
            420                 425                 430         


Asn Ser Ser Ser Gly Gly Glu Gly Lys Thr Gly Gly Ser Arg Ser Asp 
        435                 440                 445             


Leu Asp Asn Leu Pro Pro Glu Pro Ala Gly Lys Glu Ala Pro Ser Cys 
    450                 455                 460                 


Ser Ser Arg Leu Lys Leu Ser His Ser Asp Thr Phe Ile Pro Leu Leu 
465                 470                 475                 480 


Thr Glu Glu Lys His His Arg Thr Arg Leu Gln Ser Cys Lys 
                485                 490                 


<210>  2593
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  2593

Met Thr Leu Leu Pro Gly Asp Asn Ser Asp Tyr Asp Tyr Ser Ala Leu 
1               5                   10                  15      


Ser Cys Thr Ser Asp Ala Ser Phe His Pro Ala Phe Leu Pro Gln Arg 
            20                  25                  30          


Gln Ala Ile Lys Gly Ala Phe Tyr Arg Arg Ala Gln Arg Leu Arg Pro 
        35                  40                  45              


Gln Asp Glu Pro Arg Gln Gly Cys Gln Pro Glu Asp Arg Arg Arg Arg 
    50                  55                  60                  


Ile Ile Ile Asn Val Gly Gly Ile Lys Tyr Ser Leu Pro Trp Thr Thr 
65                  70                  75                  80  


Leu Asp Glu Phe Pro Leu Thr Arg Leu Gly Gln Leu Lys Ala Cys Thr 
                85                  90                  95      


Asn Phe Asp Asp Ile Leu Asn Val Cys Asp Asp Tyr Asp Val Thr Cys 
            100                 105                 110         


Asn Glu Phe Phe Phe Asp Arg Asn Pro Gly Ala Phe Gly Thr Ile Leu 
        115                 120                 125             


Thr Phe Leu Arg Ala Gly Lys Leu Arg Leu Leu Arg Glu Met Cys Ala 
    130                 135                 140                 


Leu Ser Phe Gln Glu Glu Leu Leu Tyr Trp Gly Ile Ala Glu Asp His 
145                 150                 155                 160 


Leu Asp Gly Cys Cys Lys Arg Arg Tyr Leu Gln Lys Ile Glu Glu Phe 
                165                 170                 175     


Ala Glu Met Val Glu Arg Glu Glu Glu Asp Asp Ala Leu Asp Ser Glu 
            180                 185                 190         


Gly Arg Asp Ser Glu Gly Pro Ala Glu Gly Glu Gly Arg Leu Gly Arg 
        195                 200                 205             


Cys Met Arg Arg Leu Arg Asp Met Val Glu Arg Pro His Ser Gly Leu 
    210                 215                 220                 


Pro Gly Lys Val Phe Ala Cys Leu Ser Val Leu Phe Val Thr Val Thr 
225                 230                 235                 240 


Ala Val Asn Leu Ser Val Ser Thr Leu Pro Ser Leu Arg Glu Glu Glu 
                245                 250                 255     


Glu Gln Gly His Cys Ser Gln Met Cys His Asn Val Phe Ile Val Glu 
            260                 265                 270         


Ser Val Cys Val Gly Trp Phe Ser Leu Glu Phe Leu Leu Arg Leu Ile 
        275                 280                 285             


Gln Ala Pro Ser Lys Phe Ala Phe Leu Arg Ser Pro Leu Thr Leu Ile 
    290                 295                 300                 


Asp Leu Val Ala Ile Leu Pro Tyr Tyr Ile Thr Leu Leu Val Asp Gly 
305                 310                 315                 320 


Ala Ala Ala Gly Arg Arg Lys Pro Gly Ala Gly Asn Ser Tyr Leu Asp 
                325                 330                 335     


Lys Val Gly Leu Val Leu Arg Val Leu Arg Ala Leu Arg Ile Leu Tyr 
            340                 345                 350         


Val Met Arg Leu Ala Arg His Ser Leu Gly Leu Gln Thr Leu Gly Leu 
        355                 360                 365             


Thr Ala Arg Arg Cys Thr Arg Glu Phe Gly Leu Leu Leu Leu Phe Leu 
    370                 375                 380                 


Cys Val Ala Ile Ala Leu Phe Ala Pro Leu Leu Tyr Val Ile Glu Asn 
385                 390                 395                 400 


Glu Met Ala Asp Ser Pro Glu Phe Thr Ser Ile Pro Ala Cys Tyr Trp 
                405                 410                 415     


Trp Ala Val Ile Thr Met Thr Thr Val Gly Tyr Gly Asp Met Val Pro 
            420                 425                 430         


Arg Ser Thr Pro Gly Gln Val Val Ala Leu Ser Ser Ile Leu Ser Gly 
        435                 440                 445             


Ile Leu Leu Met Ala Phe Pro Val Thr Ser Ile Phe His Thr Phe Ser 
    450                 455                 460                 


Arg Ser Tyr Leu Glu Leu Lys Gln Glu Gln Glu Arg Val Met Phe Arg 
465                 470                 475                 480 


Arg Ala Gln Phe Leu Ile Lys Thr Lys Ser Gln Leu Ser Val Ser Gln 
                485                 490                 495     


Asp Ser Asp Ile Leu Phe Gly Ser Ala Ser Ser Asp Thr Arg Asp Asn 
            500                 505                 510         


Asn 
    


<210>  2594
<211>  962
<212>  PRT
<213>  Homo sapiens

<400>  2594

Met Thr Met Ala Gly Gly Arg Arg Gly Leu Val Ala Pro Gln Asn Thr 
1               5                   10                  15      


Phe Leu Glu Asn Ile Val Arg Arg Ser Asn Asp Thr Asn Phe Val Leu 
            20                  25                  30          


Gly Asn Ala Gln Ile Val Asp Trp Pro Ile Val Tyr Ser Asn Asp Gly 
        35                  40                  45              


Phe Cys Lys Leu Ser Gly Tyr His Arg Ala Glu Val Met Gln Lys Ser 
    50                  55                  60                  


Ser Thr Cys Ser Phe Met Tyr Gly Glu Leu Thr Asp Lys Asp Thr Ile 
65                  70                  75                  80  


Glu Lys Val Arg Gln Thr Phe Glu Asn Tyr Glu Met Asn Ser Phe Glu 
                85                  90                  95      


Ile Leu Met Tyr Lys Lys Asn Arg Thr Pro Val Trp Phe Phe Val Lys 
            100                 105                 110         


Ile Ala Pro Ile Arg Asn Glu Gln Asp Lys Val Val Leu Phe Leu Cys 
        115                 120                 125             


Thr Phe Ser Asp Ile Thr Ala Phe Lys Gln Pro Ile Glu Asp Asp Ser 
    130                 135                 140                 


Cys Lys Gly Trp Gly Lys Phe Ala Arg Leu Thr Arg Ala Leu Thr Ser 
145                 150                 155                 160 


Ser Arg Gly Val Leu Gln Gln Leu Ala Pro Ser Val Gln Lys Gly Glu 
                165                 170                 175     


Asn Val His Lys His Ser Arg Leu Ala Glu Val Leu Gln Leu Gly Ser 
            180                 185                 190         


Asp Ile Leu Pro Gln Tyr Lys Gln Glu Ala Pro Lys Thr Pro Pro His 
        195                 200                 205             


Ile Ile Leu His Tyr Cys Val Phe Lys Thr Thr Trp Asp Trp Ile Ile 
    210                 215                 220                 


Leu Ile Leu Thr Phe Tyr Thr Ala Ile Leu Val Pro Tyr Asn Val Ser 
225                 230                 235                 240 


Phe Lys Thr Arg Gln Asn Asn Val Ala Trp Leu Val Val Asp Ser Ile 
                245                 250                 255     


Val Asp Val Ile Phe Leu Val Asp Ile Val Leu Asn Phe His Thr Thr 
            260                 265                 270         


Phe Val Gly Pro Ala Gly Glu Val Ile Ser Asp Pro Lys Leu Ile Arg 
        275                 280                 285             


Met Asn Tyr Leu Lys Thr Trp Phe Val Ile Asp Leu Leu Ser Cys Leu 
    290                 295                 300                 


Pro Tyr Asp Val Ile Asn Ala Phe Glu Asn Val Asp Glu Gly Ile Ser 
305                 310                 315                 320 


Ser Leu Phe Ser Ser Leu Lys Val Val Arg Leu Leu Arg Leu Gly Arg 
                325                 330                 335     


Val Ala Arg Lys Leu Asp His Tyr Ile Glu Tyr Gly Ala Ala Val Leu 
            340                 345                 350         


Val Leu Leu Val Cys Val Phe Gly Leu Ala Ala His Trp Met Ala Cys 
        355                 360                 365             


Ile Trp Tyr Ser Ile Gly Asp Tyr Glu Ile Phe Asp Glu Asp Thr Lys 
    370                 375                 380                 


Thr Ile Arg Asn Asn Ser Trp Leu Tyr Gln Leu Ala Met Asp Ile Gly 
385                 390                 395                 400 


Thr Pro Tyr Gln Phe Asn Gly Ser Gly Ser Gly Lys Trp Glu Gly Gly 
                405                 410                 415     


Pro Ser Lys Asn Ser Val Tyr Ile Ser Ser Leu Tyr Phe Thr Met Thr 
            420                 425                 430         


Ser Leu Thr Ser Val Gly Phe Gly Asn Ile Ala Pro Ser Thr Asp Ile 
        435                 440                 445             


Glu Lys Ile Phe Ala Val Ala Ile Met Met Ile Gly Ser Leu Leu Tyr 
    450                 455                 460                 


Ala Thr Ile Phe Gly Asn Val Thr Thr Ile Phe Gln Gln Met Tyr Ala 
465                 470                 475                 480 


Asn Thr Asn Arg Tyr His Glu Met Leu Asn Ser Val Arg Asp Phe Leu 
                485                 490                 495     


Lys Leu Tyr Gln Val Pro Lys Gly Leu Ser Glu Arg Val Met Asp Tyr 
            500                 505                 510         


Ile Val Ser Thr Trp Ser Met Ser Arg Gly Ile Asp Thr Glu Lys Val 
        515                 520                 525             


Leu Gln Ile Cys Pro Lys Asp Met Arg Ala Asp Ile Cys Val His Leu 
    530                 535                 540                 


Asn Arg Lys Val Phe Lys Glu His Pro Ala Phe Arg Leu Ala Ser Asp 
545                 550                 555                 560 


Gly Cys Leu Arg Ala Leu Ala Met Glu Phe Gln Thr Val His Cys Ala 
                565                 570                 575     


Pro Gly Asp Leu Ile Tyr His Ala Gly Glu Ser Val Asp Ser Leu Cys 
            580                 585                 590         


Phe Val Val Ser Gly Ser Leu Glu Val Ile Gln Asp Asp Glu Val Val 
        595                 600                 605             


Ala Ile Leu Gly Lys Gly Asp Val Phe Gly Asp Val Phe Trp Lys Glu 
    610                 615                 620                 


Ala Thr Leu Ala Gln Ser Cys Ala Asn Val Arg Ala Leu Thr Tyr Cys 
625                 630                 635                 640 


Asp Leu His Val Ile Lys Arg Asp Ala Leu Gln Lys Val Leu Glu Phe 
                645                 650                 655     


Tyr Thr Ala Phe Ser His Ser Phe Ser Arg Asn Leu Ile Leu Thr Tyr 
            660                 665                 670         


Asn Leu Arg Lys Arg Ile Val Phe Arg Lys Ile Ser Asp Val Lys Arg 
        675                 680                 685             


Glu Glu Glu Glu Arg Met Lys Arg Lys Asn Glu Ala Pro Leu Ile Leu 
    690                 695                 700                 


Pro Pro Asp His Pro Val Arg Arg Leu Phe Gln Arg Phe Arg Gln Gln 
705                 710                 715                 720 


Lys Glu Ala Arg Leu Ala Ala Glu Arg Gly Gly Arg Asp Leu Asp Asp 
                725                 730                 735     


Leu Asp Val Glu Lys Gly Asn Val Leu Thr Glu His Ala Ser Ala Asn 
            740                 745                 750         


His Ser Leu Val Lys Ala Ser Val Val Thr Val Arg Glu Ser Pro Ala 
        755                 760                 765             


Thr Pro Val Ser Phe Gln Ala Ala Ser Thr Ser Gly Val Pro Asp His 
    770                 775                 780                 


Ala Lys Leu Gln Ala Pro Gly Ser Glu Cys Leu Gly Pro Lys Gly Gly 
785                 790                 795                 800 


Gly Gly Asp Cys Ala Lys Arg Lys Ser Trp Ala Arg Phe Lys Asp Ala 
                805                 810                 815     


Cys Gly Lys Ser Glu Asp Trp Asn Lys Val Ser Lys Ala Glu Ser Met 
            820                 825                 830         


Glu Thr Leu Pro Glu Arg Thr Lys Ala Ser Gly Glu Ala Thr Leu Lys 
        835                 840                 845             


Lys Thr Asp Ser Cys Asp Ser Gly Ile Thr Lys Ser Asp Leu Arg Leu 
    850                 855                 860                 


Asp Asn Val Gly Glu Ala Arg Ser Pro Gln Asp Arg Ser Pro Ile Leu 
865                 870                 875                 880 


Ala Glu Val Lys His Ser Phe Tyr Pro Ile Pro Glu Gln Thr Leu Gln 
                885                 890                 895     


Ala Thr Val Leu Glu Val Arg His Glu Leu Lys Glu Asp Ile Lys Ala 
            900                 905                 910         


Leu Asn Ala Lys Met Thr Asn Ile Glu Lys Gln Leu Ser Glu Ile Leu 
        915                 920                 925             


Arg Ile Leu Thr Ser Arg Arg Ser Ser Gln Ser Pro Gln Glu Leu Phe 
    930                 935                 940                 


Glu Ile Ser Arg Pro Gln Ser Pro Glu Ser Glu Arg Asp Ile Phe Gly 
945                 950                 955                 960 


Ala Ser 
        


<210>  2595
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  2595

Met Ser Ala Leu Arg Arg Lys Phe Gly Asp Asp Tyr Gln Val Val Thr 
1               5                   10                  15      


Thr Ser Ser Ser Gly Ser Gly Leu Gln Pro Gln Gly Pro Gly Gln Asp 
            20                  25                  30          


Pro Gln Gln Gln Leu Val Pro Lys Lys Lys Arg Gln Arg Phe Val Asp 
        35                  40                  45              


Lys Asn Gly Arg Cys Asn Val Gln His Gly Asn Leu Gly Ser Glu Thr 
    50                  55                  60                  


Ser Arg Tyr Leu Ser Asp Leu Phe Thr Thr Leu Val Asp Leu Lys Trp 
65                  70                  75                  80  


Arg Trp Asn Leu Phe Ile Phe Ile Leu Thr Tyr Thr Val Ala Trp Leu 
                85                  90                  95      


Phe Met Ala Ser Met Trp Trp Val Ile Ala Tyr Thr Arg Gly Asp Leu 
            100                 105                 110         


Asn Lys Ala His Val Gly Asn Tyr Thr Pro Cys Val Ala Asn Val Tyr 
        115                 120                 125             


Asn Phe Pro Ser Ala Phe Leu Phe Phe Ile Glu Thr Glu Ala Thr Ile 
    130                 135                 140                 


Gly Tyr Gly Tyr Arg Tyr Ile Thr Asp Lys Cys Pro Glu Gly Ile Ile 
145                 150                 155                 160 


Leu Phe Leu Phe Gln Ser Ile Leu Gly Ser Ile Val Asp Ala Phe Leu 
                165                 170                 175     


Ile Gly Cys Met Phe Ile Lys Met Ser Gln Pro Lys Lys Arg Ala Glu 
            180                 185                 190         


Thr Leu Met Phe Ser Glu His Ala Val Ile Ser Met Arg Asp Gly Lys 
        195                 200                 205             


Leu Thr Leu Met Phe Arg Val Gly Asn Leu Arg Asn Ser His Met Val 
    210                 215                 220                 


Ser Ala Gln Ile Arg Cys Lys Leu Leu Lys Ser Arg Gln Thr Pro Glu 
225                 230                 235                 240 


Gly Glu Phe Leu Pro Leu Asp Gln Leu Glu Leu Asp Val Gly Phe Ser 
                245                 250                 255     


Thr Gly Ala Asp Gln Leu Phe Leu Val Ser Pro Leu Thr Ile Cys His 
            260                 265                 270         


Val Ile Asp Ala Lys Ser Pro Phe Tyr Asp Leu Ser Gln Arg Ser Met 
        275                 280                 285             


Gln Thr Glu Gln Phe Glu Ile Val Val Ile Leu Glu Gly Ile Val Glu 
    290                 295                 300                 


Thr Thr Gly Met Thr Cys Gln Ala Arg Thr Ser Tyr Thr Glu Asp Glu 
305                 310                 315                 320 


Val Leu Trp Gly His Arg Phe Phe Pro Val Ile Ser Leu Glu Glu Gly 
                325                 330                 335     


Phe Phe Lys Val Asp Tyr Ser Gln Phe His Ala Thr Phe Glu Val Pro 
            340                 345                 350         


Thr Pro Pro Tyr Ser Val Lys Glu Gln Glu Glu Met Leu Leu Met Ser 
        355                 360                 365             


Ser Pro Leu Ile Ala Pro Ala Ile Thr Asn Ser Lys Glu Arg His Asn 
    370                 375                 380                 


Ser Val Glu Cys Leu Asp Gly Leu Asp Asp Ile Thr Thr Lys Leu Pro 
385                 390                 395                 400 


Ser Lys Leu Gln Lys Ile Thr Gly Arg Glu Asp Phe Pro Lys Lys Leu 
                405                 410                 415     


Leu Arg Met Ser Ser Thr Thr Ser Glu Lys Ala Tyr Ser Leu Gly Asp 
            420                 425                 430         


Leu Pro Met Lys Leu Gln Arg Ile Ser Ser Val Pro Gly Asn Ser Glu 
        435                 440                 445             


Glu Lys Leu Val Ser Lys Thr Thr Lys Met Leu Ser Asp Pro Met Ser 
    450                 455                 460                 


Gln Ser Val Ala Asp Leu Pro Pro Lys Leu Gln Lys Met Ala Gly Gly 
465                 470                 475                 480 


Ala Ala Arg Met Glu Gly Asn Leu Pro Ala Lys Leu Arg Lys Met Asn 
                485                 490                 495     


Ser Asp Arg Phe Thr 
            500     


<210>  2596
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  2596

Met Ala Lys Leu Thr Glu Ser Met Thr Asn Val Leu Glu Gly Asp Ser 
1               5                   10                  15      


Met Asp Gln Asp Val Glu Ser Pro Val Ala Ile His Gln Pro Lys Leu 
            20                  25                  30          


Pro Lys Gln Ala Arg Asp Asp Leu Pro Arg His Ile Ser Arg Asp Arg 
        35                  40                  45              


Thr Lys Arg Lys Ile Gln Arg Tyr Val Arg Lys Asp Gly Lys Cys Asn 
    50                  55                  60                  


Val His His Gly Asn Val Arg Glu Thr Tyr Arg Tyr Leu Thr Asp Ile 
65                  70                  75                  80  


Phe Thr Thr Leu Val Asp Leu Lys Trp Arg Phe Asn Leu Leu Ile Phe 
                85                  90                  95      


Val Met Val Tyr Thr Val Thr Trp Leu Phe Phe Gly Met Ile Trp Trp 
            100                 105                 110         


Leu Ile Ala Tyr Ile Arg Gly Asp Met Asp His Ile Glu Asp Pro Ser 
        115                 120                 125             


Trp Thr Pro Cys Val Thr Asn Leu Asn Gly Phe Val Ser Ala Phe Leu 
    130                 135                 140                 


Phe Ser Ile Glu Thr Glu Thr Thr Ile Gly Tyr Gly Tyr Arg Val Ile 
145                 150                 155                 160 


Thr Asp Lys Cys Pro Glu Gly Ile Ile Leu Leu Leu Ile Gln Ser Val 
                165                 170                 175     


Leu Gly Ser Ile Val Asn Ala Phe Met Val Gly Cys Met Phe Val Lys 
            180                 185                 190         


Ile Ser Gln Pro Lys Lys Arg Ala Glu Thr Leu Val Phe Ser Thr His 
        195                 200                 205             


Ala Val Ile Ser Met Arg Asp Gly Lys Leu Cys Leu Met Phe Arg Val 
    210                 215                 220                 


Gly Asp Leu Arg Asn Ser His Ile Val Glu Ala Ser Ile Arg Ala Lys 
225                 230                 235                 240 


Leu Ile Lys Ser Lys Gln Thr Ser Glu Gly Glu Phe Ile Pro Leu Asn 
                245                 250                 255     


Gln Thr Asp Ile Asn Val Gly Tyr Tyr Thr Gly Asp Asp Arg Leu Phe 
            260                 265                 270         


Leu Val Ser Pro Leu Ile Ile Ser His Glu Ile Asn Gln Gln Ser Pro 
        275                 280                 285             


Phe Trp Glu Ile Ser Lys Ala Gln Leu Pro Lys Glu Glu Leu Glu Ile 
    290                 295                 300                 


Val Val Ile Leu Glu Gly Met Val Glu Ala Thr Gly Met Thr Cys Gln 
305                 310                 315                 320 


Ala Arg Ser Ser Tyr Ile Thr Ser Glu Ile Leu Trp Gly Tyr Arg Phe 
                325                 330                 335     


Thr Pro Val Leu Thr Leu Glu Asp Gly Phe Tyr Glu Val Asp Tyr Asn 
            340                 345                 350         


Ser Phe His Glu Thr Tyr Glu Thr Ser Thr Pro Ser Leu Ser Ala Lys 
        355                 360                 365             


Glu Leu Ala Glu Leu Ala Ser Arg Ala Glu Leu Pro Leu Ser Trp Ser 
    370                 375                 380                 


Val Ser Ser Lys Leu Asn Gln His Ala Glu Leu Glu Thr Glu Glu Glu 
385                 390                 395                 400 


Glu Lys Asn Leu Glu Glu Gln Thr Glu Arg Asn Gly Asp Val Ala Asn 
                405                 410                 415     


Leu Glu Asn Glu Ser Lys Val 
            420             


<210>  2597
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  2597

Met Thr Ser Val Ala Lys Val Tyr Tyr Ser Gln Thr Thr Gln Thr Glu 
1               5                   10                  15      


Ser Arg Pro Leu Met Gly Pro Gly Ile Arg Arg Arg Arg Val Leu Thr 
            20                  25                  30          


Lys Asp Gly Arg Ser Asn Val Arg Met Glu His Ile Ala Asp Lys Arg 
        35                  40                  45              


Phe Leu Tyr Leu Lys Asp Leu Trp Thr Thr Phe Ile Asp Met Gln Trp 
    50                  55                  60                  


Arg Tyr Lys Leu Leu Leu Phe Ser Ala Thr Phe Ala Gly Thr Trp Phe 
65                  70                  75                  80  


Leu Phe Gly Val Val Trp Tyr Leu Val Ala Val Ala His Gly Asp Leu 
                85                  90                  95      


Leu Glu Leu Asp Pro Pro Ala Asn His Thr Pro Cys Val Val Gln Val 
            100                 105                 110         


His Thr Leu Thr Gly Ala Phe Leu Phe Ser Leu Glu Ser Gln Thr Thr 
        115                 120                 125             


Ile Gly Tyr Gly Phe Arg Tyr Ile Ser Glu Glu Cys Pro Leu Ala Ile 
    130                 135                 140                 


Val Leu Leu Ile Ala Gln Leu Val Leu Thr Thr Ile Leu Glu Ile Phe 
145                 150                 155                 160 


Ile Thr Gly Thr Phe Leu Ala Lys Ile Ala Arg Pro Lys Lys Arg Ala 
                165                 170                 175     


Glu Thr Ile Arg Phe Ser Gln His Ala Val Val Ala Ser His Asn Gly 
            180                 185                 190         


Lys Pro Cys Leu Met Ile Arg Val Ala Asn Met Arg Lys Ser Leu Leu 
        195                 200                 205             


Ile Gly Cys Gln Val Thr Gly Lys Leu Leu Gln Thr His Gln Thr Lys 
    210                 215                 220                 


Glu Gly Glu Asn Ile Arg Leu Asn Gln Val Asn Val Thr Phe Gln Val 
225                 230                 235                 240 


Asp Thr Ala Ser Asp Ser Pro Phe Leu Ile Leu Pro Leu Thr Phe Tyr 
                245                 250                 255     


His Val Val Asp Glu Thr Ser Pro Leu Lys Asp Leu Pro Leu Arg Ser 
            260                 265                 270         


Gly Glu Gly Asp Phe Glu Leu Val Leu Ile Leu Ser Gly Thr Val Glu 
        275                 280                 285             


Ser Thr Ser Ala Thr Cys Gln Val Arg Thr Ser Tyr Leu Pro Glu Glu 
    290                 295                 300                 


Ile Leu Trp Gly Tyr Glu Phe Thr Pro Ala Ile Ser Leu Ser Ala Ser 
305                 310                 315                 320 


Gly Lys Tyr Ile Ala Asp Phe Ser Leu Phe Asp Gln Val Val Lys Val 
                325                 330                 335     


Ala Ser Pro Ser Gly Leu Arg Asp Ser Thr Val Arg Tyr Gly Asp Pro 
            340                 345                 350         


Glu Lys Leu Lys Leu Glu Glu Ser Leu Arg Glu Gln Ala Glu Lys Glu 
        355                 360                 365             


Gly Ser Ala Leu Ser Val Arg Ile Ser Asn Val 
    370                 375                 


<210>  2598
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  2598

Met Asp Ser Ser Asn Cys Lys Val Ile Ala Pro Leu Leu Ser Gln Arg 
1               5                   10                  15      


Tyr Arg Arg Met Val Thr Lys Asp Gly His Ser Thr Leu Gln Met Asp 
            20                  25                  30          


Gly Ala Gln Arg Gly Leu Ala Tyr Leu Arg Asp Ala Trp Gly Ile Leu 
        35                  40                  45              


Met Asp Met Arg Trp Arg Trp Met Met Leu Val Phe Ser Ala Ser Phe 
    50                  55                  60                  


Val Val His Trp Leu Val Phe Ala Val Leu Trp Tyr Val Leu Ala Glu 
65                  70                  75                  80  


Met Asn Gly Asp Leu Glu Leu Asp His Asp Ala Pro Pro Glu Asn His 
                85                  90                  95      


Thr Ile Cys Val Lys Tyr Ile Thr Ser Phe Thr Ala Ala Phe Ser Phe 
            100                 105                 110         


Ser Leu Glu Thr Gln Leu Thr Ile Gly Tyr Gly Thr Met Phe Pro Ser 
        115                 120                 125             


Gly Asp Cys Pro Ser Ala Ile Ala Leu Leu Ala Ile Gln Met Leu Leu 
    130                 135                 140                 


Gly Leu Met Leu Glu Ala Phe Ile Thr Gly Ala Phe Val Ala Lys Ile 
145                 150                 155                 160 


Ala Arg Pro Lys Asn Arg Ala Phe Ser Ile Arg Phe Thr Asp Thr Ala 
                165                 170                 175     


Val Val Ala His Met Asp Gly Lys Pro Asn Leu Ile Phe Gln Val Ala 
            180                 185                 190         


Asn Thr Arg Pro Ser Pro Leu Thr Ser Val Arg Val Ser Ala Val Leu 
        195                 200                 205             


Tyr Gln Glu Arg Glu Asn Gly Lys Leu Tyr Gln Thr Ser Val Asp Phe 
    210                 215                 220                 


His Leu Asp Gly Ile Ser Ser Asp Glu Cys Pro Phe Phe Ile Phe Pro 
225                 230                 235                 240 


Leu Thr Tyr Tyr His Ser Ile Thr Pro Ser Ser Pro Leu Ala Thr Leu 
                245                 250                 255     


Leu Gln His Glu Asn Pro Ser His Phe Glu Leu Val Val Phe Leu Ser 
            260                 265                 270         


Ala Met Gln Glu Gly Thr Gly Glu Ile Cys Gln Arg Arg Thr Ser Tyr 
        275                 280                 285             


Leu Pro Ser Glu Ile Met Leu His His Cys Phe Ala Ser Leu Leu Thr 
    290                 295                 300                 


Arg Gly Ser Lys Gly Glu Tyr Gln Ile Lys Met Glu Asn Phe Asp Lys 
305                 310                 315                 320 


Thr Val Pro Glu Phe Pro Thr Pro Leu Val Ser Lys Ser Pro Asn Arg 
                325                 330                 335     


Thr Asp Leu Asp Ile His Ile Asn Gly Gln Ser Ile Asp Asn Phe Gln 
            340                 345                 350         


Ile Ser Glu Thr Gly Leu Thr Glu 
        355                 360 


<210>  2599
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  2599

Met Asp Ala Ile His Ile Gly Met Ser Ser Thr Pro Leu Val Lys His 
1               5                   10                  15      


Thr Ala Gly Ala Gly Leu Lys Ala Asn Arg Pro Arg Val Met Ser Lys 
            20                  25                  30          


Ser Gly His Ser Asn Val Arg Ile Asp Lys Val Asp Gly Ile Tyr Leu 
        35                  40                  45              


Leu Tyr Leu Gln Asp Leu Trp Thr Thr Val Ile Asp Met Lys Trp Arg 
    50                  55                  60                  


Tyr Lys Leu Thr Leu Phe Ala Ala Thr Phe Val Met Thr Trp Phe Leu 
65                  70                  75                  80  


Phe Gly Val Ile Tyr Tyr Ala Ile Ala Phe Ile His Gly Asp Leu Glu 
                85                  90                  95      


Pro Gly Glu Pro Ile Ser Asn His Thr Pro Cys Ile Met Lys Val Asp 
            100                 105                 110         


Ser Leu Thr Gly Ala Phe Leu Phe Ser Leu Glu Ser Gln Thr Thr Ile 
        115                 120                 125             


Gly Tyr Gly Val Arg Ser Ile Thr Glu Glu Cys Pro His Ala Ile Phe 
    130                 135                 140                 


Leu Leu Val Ala Gln Leu Val Ile Thr Thr Leu Ile Glu Ile Phe Ile 
145                 150                 155                 160 


Thr Gly Thr Phe Leu Ala Lys Ile Ala Arg Pro Lys Lys Arg Ala Glu 
                165                 170                 175     


Thr Ile Lys Phe Ser His Cys Ala Val Ile Thr Lys Gln Asn Gly Lys 
            180                 185                 190         


Leu Cys Leu Val Ile Gln Val Ala Asn Met Arg Lys Ser Leu Leu Ile 
        195                 200                 205             


Gln Cys Gln Leu Ser Gly Lys Leu Leu Gln Thr His Val Thr Lys Glu 
    210                 215                 220                 


Gly Glu Arg Ile Leu Leu Asn Gln Ala Thr Val Lys Phe His Val Asp 
225                 230                 235                 240 


Ser Ser Ser Glu Ser Pro Phe Leu Ile Leu Pro Met Thr Phe Tyr His 
                245                 250                 255     


Val Leu Asp Glu Thr Ser Pro Leu Arg Asp Leu Thr Pro Gln Asn Leu 
            260                 265                 270         


Lys Glu Lys Glu Phe Glu Leu Val Val Leu Leu Asn Ala Thr Val Glu 
        275                 280                 285             


Ser Thr Ser Ala Val Cys Gln Ser Arg Thr Ser Tyr Ile Pro Glu Glu 
    290                 295                 300                 


Ile Tyr Trp Gly Phe Glu Phe Val Pro Val Val Ser Leu Ser Lys Asn 
305                 310                 315                 320 


Gly Lys Tyr Val Ala Asp Phe Ser Gln Phe Glu Gln Ile Arg Lys Ser 
                325                 330                 335     


Pro Asp Cys Thr Phe Tyr Cys Ala Asp Ser Glu Lys Gln Gln Leu Glu 
            340                 345                 350         


Glu Lys Tyr Arg Gln Glu Asp Gln Arg Glu Arg Glu Leu Arg Thr Leu 
        355                 360                 365             


Leu Leu Gln Gln Ser Asn Val 
    370                 375 


<210>  2600
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  2600

Met Leu Gln Ser Leu Ala Gly Ser Ser Cys Val Arg Leu Val Glu Arg 
1               5                   10                  15      


His Arg Ser Ala Trp Cys Phe Gly Phe Leu Val Leu Gly Tyr Leu Leu 
            20                  25                  30          


Tyr Leu Val Phe Gly Ala Val Val Phe Ser Ser Val Glu Leu Pro Tyr 
        35                  40                  45              


Glu Asp Leu Leu Arg Gln Glu Leu Arg Lys Leu Lys Arg Arg Phe Leu 
    50                  55                  60                  


Glu Glu His Glu Cys Leu Ser Glu Gln Gln Leu Glu Gln Phe Leu Gly 
65                  70                  75                  80  


Arg Val Leu Glu Ala Ser Asn Tyr Gly Val Ser Val Leu Ser Asn Ala 
                85                  90                  95      


Ser Gly Asn Trp Asn Trp Asp Phe Thr Ser Ala Leu Phe Phe Ala Ser 
            100                 105                 110         


Thr Val Leu Ser Thr Thr Gly Tyr Gly His Thr Val Pro Leu Ser Asp 
        115                 120                 125             


Gly Gly Lys Ala Phe Cys Ile Ile Tyr Ser Val Ile Gly Ile Pro Phe 
    130                 135                 140                 


Thr Leu Leu Phe Leu Thr Ala Val Val Gln Arg Ile Thr Val His Val 
145                 150                 155                 160 


Thr Arg Arg Pro Val Leu Tyr Phe His Ile Arg Trp Gly Phe Ser Lys 
                165                 170                 175     


Gln Val Val Ala Ile Val His Ala Val Leu Leu Gly Phe Val Thr Val 
            180                 185                 190         


Ser Cys Phe Phe Phe Ile Pro Ala Ala Val Phe Ser Val Leu Glu Asp 
        195                 200                 205             


Asp Trp Asn Phe Leu Glu Ser Phe Tyr Phe Cys Phe Ile Ser Leu Ser 
    210                 215                 220                 


Thr Ile Gly Leu Gly Asp Tyr Val Pro Gly Glu Gly Tyr Asn Gln Lys 
225                 230                 235                 240 


Phe Arg Glu Leu Tyr Lys Ile Gly Ile Thr Cys Tyr Leu Leu Leu Gly 
                245                 250                 255     


Leu Ile Ala Met Leu Val Val Leu Glu Thr Phe Cys Glu Leu His Glu 
            260                 265                 270         


Leu Lys Lys Phe Arg Lys Met Phe Tyr Val Lys Lys Asp Lys Asp Glu 
        275                 280                 285             


Asp Gln Val His Ile Ile Glu His Asp Gln Leu Ser Phe Ser Ser Ile 
    290                 295                 300                 


Thr Asp Gln Ala Ala Gly Met Lys Glu Asp Gln Lys Gln Asn Glu Pro 
305                 310                 315                 320 


Phe Val Ala Thr Gln Ser Ser Ala Cys Val Asp Gly Pro Ala Asn His 
                325                 330                 335     


<210>  2601
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  2601

Met Lys Arg Gln Asn Val Arg Thr Leu Ala Leu Ile Val Cys Thr Phe 
1               5                   10                  15      


Thr Tyr Leu Leu Val Gly Ala Ala Val Phe Asp Ala Leu Glu Ser Glu 
            20                  25                  30          


Pro Glu Leu Ile Glu Arg Gln Arg Leu Glu Leu Arg Gln Gln Glu Leu 
        35                  40                  45              


Arg Ala Arg Tyr Asn Leu Ser Gln Gly Gly Tyr Glu Glu Leu Glu Arg 
    50                  55                  60                  


Val Val Leu Arg Leu Lys Pro His Lys Ala Gly Val Gln Trp Arg Phe 
65                  70                  75                  80  


Ala Gly Ser Phe Tyr Phe Ala Ile Thr Val Ile Thr Thr Ile Gly Tyr 
                85                  90                  95      


Gly His Ala Ala Pro Ser Thr Asp Gly Gly Lys Val Phe Cys Met Phe 
            100                 105                 110         


Tyr Ala Leu Leu Gly Ile Pro Leu Thr Leu Val Met Phe Gln Ser Leu 
        115                 120                 125             


Gly Glu Arg Ile Asn Thr Leu Val Arg Tyr Leu Leu His Arg Ala Lys 
    130                 135                 140                 


Lys Gly Leu Gly Met Arg Arg Ala Asp Val Ser Met Ala Asn Met Val 
145                 150                 155                 160 


Leu Ile Gly Phe Phe Ser Cys Ile Ser Thr Leu Cys Ile Gly Ala Ala 
                165                 170                 175     


Ala Phe Ser His Tyr Glu His Trp Thr Phe Phe Gln Ala Tyr Tyr Tyr 
            180                 185                 190         


Cys Phe Ile Thr Leu Thr Thr Ile Gly Phe Gly Asp Tyr Val Ala Leu 
        195                 200                 205             


Gln Lys Asp Gln Ala Leu Gln Thr Gln Pro Gln Tyr Val Ala Phe Ser 
    210                 215                 220                 


Phe Val Tyr Ile Leu Thr Gly Leu Thr Val Ile Gly Ala Phe Leu Asn 
225                 230                 235                 240 


Leu Val Val Leu Arg Phe Met Thr Met Asn Ala Glu Asp Glu Lys Arg 
                245                 250                 255     


Asp Ala Glu His Arg Ala Leu Leu Thr Arg Asn Gly Gln Ala Gly Gly 
            260                 265                 270         


Gly Gly Gly Gly Gly Ser Ala His Thr Thr Asp Thr Ala Ser Ser Thr 
        275                 280                 285             


Ala Ala Ala Gly Gly Gly Gly Phe Arg Asn Val Tyr Ala Glu Val Leu 
    290                 295                 300                 


His Phe Gln Ser Met Cys Ser Cys Leu Trp Tyr Lys Ser Arg Glu Lys 
305                 310                 315                 320 


Leu Gln Tyr Ser Ile Pro Met Ile Ile Pro Arg Asp Leu Ser Thr Ser 
                325                 330                 335     


Asp Thr Cys Val Glu Gln Ser His Ser Ser Pro Gly Gly Gly Gly Arg 
            340                 345                 350         


Tyr Ser Asp Thr Pro Ser Arg Arg Cys Leu Cys Ser Gly Ala Pro Arg 
        355                 360                 365             


Ser Ala Ile Ser Ser Val Ser Thr Gly Leu His Ser Leu Ser Thr Phe 
    370                 375                 380                 


Arg Gly Leu Met Lys Arg Arg Ser Ser Val 
385                 390                 


<210>  2602
<211>  1178
<212>  PRT
<213>  Homo sapiens

<400>  2602

Met Ala Asn Gly Gly Gly Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Ser Ser Leu Arg Met Ser Ser Asn Ile His Ala Asn 
            20                  25                  30          


His Leu Ser Leu Asp Ala Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
        35                  40                  45              


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Val His Glu Pro 
    50                  55                  60                  


Lys Met Asp Ala Leu Ile Ile Pro Val Thr Met Glu Val Pro Cys Asp 
65                  70                  75                  80  


Ser Arg Gly Gln Arg Met Trp Trp Ala Phe Leu Ala Ser Ser Met Val 
                85                  90                  95      


Thr Phe Phe Gly Gly Leu Phe Ile Ile Leu Leu Trp Arg Thr Leu Lys 
            100                 105                 110         


Tyr Leu Trp Thr Val Cys Cys His Cys Gly Gly Lys Thr Lys Glu Ala 
        115                 120                 125             


Gln Lys Ile Asn Asn Gly Ser Ser Gln Ala Asp Gly Thr Leu Lys Pro 
    130                 135                 140                 


Val Asp Glu Lys Glu Glu Ala Val Ala Ala Glu Val Gly Trp Met Thr 
145                 150                 155                 160 


Ser Val Lys Asp Trp Ala Gly Val Met Ile Ser Ala Gln Thr Leu Thr 
                165                 170                 175     


Gly Arg Val Leu Val Val Leu Val Phe Ala Leu Ser Ile Gly Ala Leu 
            180                 185                 190         


Val Ile Tyr Phe Ile Asp Ser Ser Asn Pro Ile Glu Ser Cys Gln Asn 
        195                 200                 205             


Phe Tyr Lys Asp Phe Thr Leu Gln Ile Asp Met Ala Phe Asn Val Phe 
    210                 215                 220                 


Phe Leu Leu Tyr Phe Gly Leu Arg Phe Ile Ala Ala Asn Asp Lys Leu 
225                 230                 235                 240 


Trp Phe Trp Leu Glu Val Asn Ser Val Val Asp Phe Phe Thr Val Pro 
                245                 250                 255     


Pro Val Phe Val Ser Val Tyr Leu Asn Arg Ser Trp Leu Gly Leu Arg 
            260                 265                 270         


Phe Leu Arg Ala Leu Arg Leu Ile Gln Phe Ser Glu Ile Leu Gln Phe 
        275                 280                 285             


Leu Asn Ile Leu Lys Thr Ser Asn Ser Ile Lys Leu Val Asn Leu Leu 
    290                 295                 300                 


Ser Ile Phe Ile Ser Thr Trp Leu Thr Ala Ala Gly Phe Ile His Leu 
305                 310                 315                 320 


Val Glu Asn Ser Gly Asp Pro Trp Glu Asn Phe Gln Asn Asn Gln Ala 
                325                 330                 335     


Leu Thr Tyr Trp Glu Cys Val Tyr Leu Leu Met Val Thr Met Ser Thr 
            340                 345                 350         


Val Gly Tyr Gly Asp Val Tyr Ala Lys Thr Thr Leu Gly Arg Leu Phe 
        355                 360                 365             


Met Val Phe Phe Ile Leu Gly Gly Leu Ala Met Phe Ala Ser Tyr Val 
    370                 375                 380                 


Pro Glu Ile Ile Glu Leu Ile Gly Asn Arg Lys Lys Tyr Gly Gly Ser 
385                 390                 395                 400 


Tyr Ser Ala Val Ser Gly Arg Lys His Ile Val Val Cys Gly His Ile 
                405                 410                 415     


Thr Leu Glu Ser Val Ser Asn Phe Leu Lys Asp Phe Leu His Lys Asp 
            420                 425                 430         


Arg Asp Asp Val Asn Val Glu Ile Val Phe Leu His Asn Ile Ser Pro 
        435                 440                 445             


Asn Leu Glu Leu Glu Ala Leu Phe Lys Arg His Phe Thr Gln Val Glu 
    450                 455                 460                 


Phe Tyr Gln Gly Ser Val Leu Asn Pro His Asp Leu Ala Arg Val Lys 
465                 470                 475                 480 


Ile Glu Ser Ala Asp Ala Cys Leu Ile Leu Ala Asn Lys Tyr Cys Ala 
                485                 490                 495     


Asp Pro Asp Ala Glu Asp Ala Ser Asn Ile Met Arg Val Ile Ser Ile 
            500                 505                 510         


Lys Asn Tyr His Pro Lys Ile Arg Ile Ile Thr Gln Met Leu Gln Tyr 
        515                 520                 525             


His Asn Lys Ala His Leu Leu Asn Ile Pro Ser Trp Asn Trp Lys Glu 
    530                 535                 540                 


Gly Asp Asp Ala Ile Cys Leu Ala Glu Leu Lys Leu Gly Phe Ile Ala 
545                 550                 555                 560 


Gln Ser Cys Leu Ala Gln Gly Leu Ser Thr Met Leu Ala Asn Leu Phe 
                565                 570                 575     


Ser Met Arg Ser Phe Ile Lys Ile Glu Glu Asp Thr Trp Gln Lys Tyr 
            580                 585                 590         


Tyr Leu Glu Gly Val Ser Asn Glu Met Tyr Thr Glu Tyr Leu Ser Ser 
        595                 600                 605             


Ala Phe Val Gly Leu Ser Phe Pro Thr Val Cys Glu Leu Cys Phe Val 
    610                 615                 620                 


Lys Leu Lys Leu Leu Met Ile Ala Ile Glu Tyr Lys Ser Ala Asn Arg 
625                 630                 635                 640 


Glu Ser Arg Ile Leu Ile Asn Pro Gly Asn His Leu Lys Ile Gln Glu 
                645                 650                 655     


Gly Thr Leu Gly Phe Phe Ile Ala Ser Asp Ala Lys Glu Val Lys Arg 
            660                 665                 670         


Ala Phe Phe Tyr Cys Lys Ala Cys His Asp Asp Ile Thr Asp Pro Lys 
        675                 680                 685             


Arg Ile Lys Lys Cys Gly Cys Lys Arg Leu Glu Asp Glu Gln Pro Ser 
    690                 695                 700                 


Thr Leu Ser Pro Lys Lys Lys Gln Arg Asn Gly Gly Met Arg Asn Ser 
705                 710                 715                 720 


Pro Asn Thr Ser Pro Lys Leu Met Arg His Asp Pro Leu Leu Ile Pro 
                725                 730                 735     


Gly Asn Asp Gln Ile Asp Asn Met Asp Ser Asn Val Lys Lys Tyr Asp 
            740                 745                 750         


Ser Thr Gly Met Phe His Trp Cys Ala Pro Lys Glu Ile Glu Lys Val 
        755                 760                 765             


Ile Leu Thr Arg Ser Glu Ala Ala Met Thr Val Leu Ser Gly His Val 
    770                 775                 780                 


Val Val Cys Ile Phe Gly Asp Val Ser Ser Ala Leu Ile Gly Leu Arg 
785                 790                 795                 800 


Asn Leu Val Met Pro Leu Arg Ala Ser Asn Phe His Tyr His Glu Leu 
                805                 810                 815     


Lys His Ile Val Phe Val Gly Ser Ile Glu Tyr Leu Lys Arg Glu Trp 
            820                 825                 830         


Glu Thr Leu His Asn Phe Pro Lys Val Ser Ile Leu Pro Gly Thr Pro 
        835                 840                 845             


Leu Ser Arg Ala Asp Leu Arg Ala Val Asn Ile Asn Leu Cys Asp Met 
    850                 855                 860                 


Cys Val Ile Leu Ser Ala Asn Gln Asn Asn Ile Asp Asp Thr Ser Leu 
865                 870                 875                 880 


Gln Asp Lys Glu Cys Ile Leu Ala Ser Leu Asn Ile Lys Ser Met Gln 
                885                 890                 895     


Phe Asp Asp Ser Ile Gly Val Leu Gln Ala Asn Ser Gln Gly Phe Thr 
            900                 905                 910         


Pro Pro Gly Met Asp Arg Ser Ser Pro Asp Asn Ser Pro Val His Gly 
        915                 920                 925             


Met Leu Arg Gln Pro Ser Ile Thr Thr Gly Val Asn Ile Pro Ile Ile 
    930                 935                 940                 


Thr Glu Leu Val Asn Asp Thr Asn Val Gln Phe Leu Asp Gln Asp Asp 
945                 950                 955                 960 


Asp Asp Asp Pro Asp Thr Glu Leu Tyr Leu Thr Gln Pro Phe Ala Cys 
                965                 970                 975     


Gly Thr Ala Phe Ala Val Ser Val Leu Asp Ser Leu Met Ser Ala Thr 
            980                 985                 990         


Tyr Phe Asn Asp Asn Ile Leu Thr  Leu Ile Arg Thr Leu  Val Thr Gly 
        995                 1000                 1005             


Gly Ala  Thr Pro Glu Leu Glu  Ala Leu Ile Ala Glu  Glu Asn Ala 
    1010                 1015                 1020             


Leu Arg  Gly Gly Tyr Ser Thr  Pro Gln Thr Leu Ala  Asn Arg Asp 
    1025                 1030                 1035             


Arg Cys  Arg Val Ala Gln Leu  Ala Leu Leu Asp Gly  Pro Phe Ala 
    1040                 1045                 1050             


Asp Leu  Gly Asp Gly Gly Cys  Tyr Gly Asp Leu Phe  Cys Lys Ala 
    1055                 1060                 1065             


Leu Lys  Thr Tyr Asn Met Leu  Cys Phe Gly Ile Tyr  Arg Leu Arg 
    1070                 1075                 1080             


Asp Ala  His Leu Ser Thr Pro  Ser Gln Cys Thr Lys  Arg Tyr Val 
    1085                 1090                 1095             


Ile Thr  Asn Pro Pro Tyr Glu  Phe Glu Leu Val Pro  Thr Asp Leu 
    1100                 1105                 1110             


Ile Phe  Cys Leu Met Gln Phe  Asp His Asn Ala Gly  Gln Ser Arg 
    1115                 1120                 1125             


Ala Ser  Leu Ser His Ser Ser  His Ser Ser Gln Ser  Ser Ser Lys 
    1130                 1135                 1140             


Lys Ser  Ser Ser Val His Ser  Ile Pro Ser Thr Ala  Asn Arg Gln 
    1145                 1150                 1155             


Asn Arg  Pro Lys Ser Arg Glu  Ser Arg Asp Lys Gln  Lys Tyr Val 
    1160                 1165                 1170             


Gln Glu  Glu Arg Leu 
    1175             


<210>  2603
<211>  731
<212>  PRT
<213>  Homo sapiens

<400>  2603

Met Asp Thr Ser Gly His Phe His Asp Ser Gly Val Gly Asp Leu Asp 
1               5                   10                  15      


Glu Asp Pro Lys Cys Pro Cys Pro Ser Ser Gly Asp Glu Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Ala Pro Pro 
        35                  40                  45              


Ala Ala Pro Gln Gln Pro Leu Gly Pro Ser Leu Gln Pro Gln Pro Pro 
    50                  55                  60                  


Gln Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Pro Pro His Pro Leu Ser Gln Leu Ala Gln Leu Gln Ser Gln Pro Val 
                85                  90                  95      


His Pro Gly Leu Leu His Ser Ser Pro Thr Ala Phe Arg Ala Pro Pro 
            100                 105                 110         


Ser Ser Asn Ser Thr Ala Ile Leu His Pro Ser Ser Arg Gln Gly Ser 
        115                 120                 125             


Gln Leu Asn Leu Asn Asp His Leu Leu Gly His Ser Pro Ser Ser Thr 
    130                 135                 140                 


Ala Thr Ser Gly Pro Gly Gly Gly Ser Arg His Arg Gln Ala Ser Pro 
145                 150                 155                 160 


Leu Val His Arg Arg Asp Ser Asn Pro Phe Thr Glu Ile Ala Met Ser 
                165                 170                 175     


Ser Cys Lys Tyr Ser Gly Gly Val Met Lys Pro Leu Ser Arg Leu Ser 
            180                 185                 190         


Ala Ser Arg Arg Asn Leu Ile Glu Ala Glu Thr Glu Gly Gln Pro Leu 
        195                 200                 205             


Gln Leu Phe Ser Pro Ser Asn Pro Pro Glu Ile Val Ile Ser Ser Arg 
    210                 215                 220                 


Glu Asp Asn His Ala His Gln Thr Leu Leu His His Pro Asn Ala Thr 
225                 230                 235                 240 


His Asn His Gln His Ala Gly Thr Thr Ala Ser Ser Thr Thr Phe Pro 
                245                 250                 255     


Lys Ala Asn Lys Arg Lys Asn Gln Asn Ile Gly Tyr Lys Leu Gly His 
            260                 265                 270         


Arg Arg Ala Leu Phe Glu Lys Arg Lys Arg Leu Ser Asp Tyr Ala Leu 
        275                 280                 285             


Ile Phe Gly Met Phe Gly Ile Val Val Met Val Ile Glu Thr Glu Leu 
    290                 295                 300                 


Ser Trp Gly Leu Tyr Ser Lys Asp Ser Met Phe Ser Leu Ala Leu Lys 
305                 310                 315                 320 


Cys Leu Ile Ser Leu Ser Thr Ile Ile Leu Leu Gly Leu Ile Ile Ala 
                325                 330                 335     


Tyr His Thr Arg Glu Val Gln Leu Phe Val Ile Asp Asn Gly Ala Asp 
            340                 345                 350         


Asp Trp Arg Ile Ala Met Thr Tyr Glu Arg Ile Leu Tyr Ile Ser Leu 
        355                 360                 365             


Glu Met Leu Val Cys Ala Ile His Pro Ile Pro Gly Glu Tyr Lys Phe 
    370                 375                 380                 


Phe Trp Thr Ala Arg Leu Ala Phe Ser Tyr Thr Pro Ser Arg Ala Glu 
385                 390                 395                 400 


Ala Asp Val Asp Ile Ile Leu Ser Ile Pro Met Phe Leu Arg Leu Tyr 
                405                 410                 415     


Leu Ile Ala Arg Val Met Leu Leu His Ser Lys Leu Phe Thr Asp Ala 
            420                 425                 430         


Ser Ser Arg Ser Ile Gly Ala Leu Asn Lys Ile Asn Phe Asn Thr Arg 
        435                 440                 445             


Phe Val Met Lys Thr Leu Met Thr Ile Cys Pro Gly Thr Val Leu Leu 
    450                 455                 460                 


Val Phe Ser Ile Ser Leu Trp Ile Ile Ala Ala Trp Thr Val Arg Val 
465                 470                 475                 480 


Cys Glu Arg Tyr His Asp Gln Gln Asp Val Thr Ser Asn Phe Leu Gly 
                485                 490                 495     


Ala Met Trp Leu Ile Ser Ile Thr Phe Leu Ser Ile Gly Tyr Gly Asp 
            500                 505                 510         


Met Val Pro His Thr Tyr Cys Gly Lys Gly Val Cys Leu Leu Thr Gly 
        515                 520                 525             


Ile Met Gly Ala Gly Cys Thr Ala Leu Val Val Ala Val Val Ala Arg 
    530                 535                 540                 


Lys Leu Glu Leu Thr Lys Ala Glu Lys His Val His Asn Phe Met Met 
545                 550                 555                 560 


Asp Thr Gln Leu Thr Lys Arg Ile Lys Asn Ala Ala Ala Asn Val Leu 
                565                 570                 575     


Arg Glu Thr Trp Leu Ile Tyr Lys His Thr Lys Leu Leu Lys Lys Ile 
            580                 585                 590         


Asp His Ala Lys Val Arg Lys His Gln Arg Lys Phe Leu Gln Ala Ile 
        595                 600                 605             


His Gln Leu Arg Ser Val Lys Met Glu Gln Arg Lys Leu Ser Asp Gln 
    610                 615                 620                 


Ala Asn Thr Leu Val Asp Leu Ser Lys Met Gln Asn Val Met Tyr Asp 
625                 630                 635                 640 


Leu Ile Thr Glu Leu Asn Asp Arg Ser Glu Asp Leu Glu Lys Gln Ile 
                645                 650                 655     


Gly Ser Leu Glu Ser Lys Leu Glu His Leu Thr Ala Ser Phe Asn Ser 
            660                 665                 670         


Leu Pro Leu Leu Ile Ala Asp Thr Leu Arg Gln Gln Gln Gln Gln Leu 
        675                 680                 685             


Leu Ser Ala Ile Ile Glu Ala Arg Gly Val Ser Val Ala Val Gly Thr 
    690                 695                 700                 


Thr His Thr Pro Ile Ser Asp Ser Pro Ile Gly Val Ser Ser Thr Ser 
705                 710                 715                 720 


Phe Pro Thr Pro Tyr Thr Ser Ser Ser Ser Cys 
                725                 730     


<210>  2604
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  2604

Met Gly Gly Asp Leu Val Leu Gly Leu Gly Ala Leu Arg Arg Arg Lys 
1               5                   10                  15      


Arg Leu Leu Glu Gln Glu Lys Ser Leu Ala Gly Trp Ala Leu Val Leu 
            20                  25                  30          


Ala Gly Thr Gly Ile Gly Leu Met Val Leu His Ala Glu Met Leu Trp 
        35                  40                  45              


Phe Gly Gly Cys Ser Trp Ala Leu Tyr Leu Phe Leu Val Lys Cys Thr 
    50                  55                  60                  


Ile Ser Ile Ser Thr Phe Leu Leu Leu Cys Leu Ile Val Ala Phe His 
65                  70                  75                  80  


Ala Lys Glu Val Gln Leu Phe Met Thr Asp Asn Gly Leu Arg Asp Trp 
                85                  90                  95      


Arg Val Ala Leu Thr Gly Arg Gln Ala Ala Gln Ile Val Leu Glu Leu 
            100                 105                 110         


Val Val Cys Gly Leu His Pro Ala Pro Val Arg Gly Pro Pro Cys Val 
        115                 120                 125             


Gln Asp Leu Gly Ala Pro Leu Thr Ser Pro Gln Pro Trp Pro Gly Phe 
    130                 135                 140                 


Leu Gly Gln Gly Glu Ala Leu Leu Ser Leu Ala Met Leu Leu Arg Leu 
145                 150                 155                 160 


Tyr Leu Val Pro Arg Ala Val Leu Leu Arg Ser Gly Val Leu Leu Asn 
                165                 170                 175     


Ala Ser Tyr Arg Ser Ile Gly Ala Leu Asn Gln Val Arg Phe Arg His 
            180                 185                 190         


Trp Phe Val Ala Lys Leu Tyr Met Asn Thr His Pro Gly Arg Leu Leu 
        195                 200                 205             


Leu Gly Leu Thr Leu Gly Leu Trp Leu Thr Thr Ala Trp Val Leu Ser 
    210                 215                 220                 


Val Ala Glu Arg Gln Ala Val Asn Ala Thr Gly His Leu Ser Asp Thr 
225                 230                 235                 240 


Leu Trp Leu Ile Pro Ile Thr Phe Leu Thr Ile Gly Tyr Gly Asp Val 
                245                 250                 255     


Val Pro Gly Thr Met Trp Gly Lys Ile Val Cys Leu Cys Thr Gly Val 
            260                 265                 270         


Met Gly Val Cys Cys Thr Ala Leu Leu Val Ala Val Val Ala Arg Lys 
        275                 280                 285             


Leu Glu Phe Asn Lys Ala Glu Lys His Val His Asn Phe Met Met Asp 
    290                 295                 300                 


Ile Gln Tyr Thr Lys Glu Met Lys Glu Ser Ala Ala Arg Val Leu Gln 
305                 310                 315                 320 


Glu Ala Trp Met Phe Tyr Lys His Thr Arg Arg Lys Glu Ser His Ala 
                325                 330                 335     


Ala Arg Arg His Gln Arg Lys Leu Leu Ala Ala Ile Asn Ala Phe Arg 
            340                 345                 350         


Gln Val Arg Leu Lys His Arg Lys Leu Arg Glu Gln Val Asn Ser Met 
        355                 360                 365             


Val Asp Ile Ser Lys Met His Met Ile Leu Tyr Asp Leu Gln Gln Asn 
    370                 375                 380                 


Leu Ser Ser Ser His Arg Ala Leu Glu Lys Gln Ile Asp Thr Leu Ala 
385                 390                 395                 400 


Gly Lys Leu Asp Ala Leu Thr Glu Leu Leu Ser Thr Ala Leu Gly Pro 
                405                 410                 415     


Arg Gln Leu Pro Glu Pro Ser Gln Gln Ser Lys 
            420                 425         


<210>  2605
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  2605

Met Leu Met Leu Leu Val Arg Gly Thr His Tyr Glu Asn Leu Arg Ser 
1               5                   10                  15      


Lys Val Val Leu Pro Thr Pro Leu Gly Gly Arg Ser Thr Glu Thr Phe 
            20                  25                  30          


Val Ser Glu Phe Pro Gly Pro Asp Thr Gly Ile Arg Trp Arg Arg Ser 
        35                  40                  45              


Asp Glu Ala Leu Arg Val Asn Val Gly Gly Val Arg Arg Gln Leu Ser 
    50                  55                  60                  


Ala Arg Ala Leu Ala Arg Phe Pro Gly Thr Arg Leu Gly Arg Leu Gln 
65                  70                  75                  80  


Ala Ala Ala Ser Glu Glu Gln Ala Arg Arg Leu Cys Asp Asp Tyr Asp 
                85                  90                  95      


Glu Ala Ala Arg Glu Phe Tyr Phe Asp Arg His Pro Gly Phe Phe Leu 
            100                 105                 110         


Ser Leu Leu His Phe Tyr Arg Thr Gly His Leu His Val Leu Asp Glu 
        115                 120                 125             


Leu Cys Val Phe Ala Phe Gly Gln Glu Ala Asp Tyr Trp Gly Leu Gly 
    130                 135                 140                 


Glu Asn Ala Leu Ala Ala Cys Cys Arg Ala Arg Tyr Leu Glu Arg Arg 
145                 150                 155                 160 


Leu Thr Gln Pro His Ala Trp Asp Glu Asp Ser Asp Thr Pro Ser Ser 
                165                 170                 175     


Val Asp Pro Cys Pro Asp Glu Ile Ser Asp Val Gln Arg Glu Leu Ala 
            180                 185                 190         


Arg Tyr Gly Ala Ala Arg Cys Gly Arg Leu Arg Arg Arg Leu Trp Leu 
        195                 200                 205             


Thr Met Glu Asn Pro Gly Tyr Ser Leu Pro Ser Lys Leu Phe Ser Cys 
    210                 215                 220                 


Val Ser Ile Ser Val Val Leu Ala Ser Ile Ala Ala Met Cys Ile His 
225                 230                 235                 240 


Ser Leu Pro Glu Tyr Gln Ala Arg Glu Ala Ala Ala Ala Val Ala Ala 
                245                 250                 255     


Val Ala Ala Gly Arg Ser Pro Glu Gly Val Arg Asp Asp Pro Val Leu 
            260                 265                 270         


Arg Arg Leu Glu Tyr Phe Cys Ile Ala Trp Phe Ser Phe Glu Val Ser 
        275                 280                 285             


Ser Arg Leu Leu Leu Ala Pro Ser Thr Arg Asn Phe Phe Cys His Pro 
    290                 295                 300                 


Leu Asn Leu Ile Asp Ile Val Ser Val Leu Pro Phe Tyr Leu Thr Leu 
305                 310                 315                 320 


Leu Ala Gly Val Ala Leu Gly Asp Gln Gly Gly Lys Glu Phe Gly His 
                325                 330                 335     


Leu Gly Lys Val Val Gln Val Phe Arg Leu Met Arg Ile Phe Arg Val 
            340                 345                 350         


Leu Lys Leu Ala Arg His Ser Thr Gly Leu Arg Ser Leu Gly Ala Thr 
        355                 360                 365             


Leu Lys His Ser Tyr Arg Glu Val Gly Ile Leu Leu Leu Tyr Leu Ala 
    370                 375                 380                 


Val Gly Val Ser Val Phe Ser Gly Val Ala Tyr Thr Ala Glu Lys Glu 
385                 390                 395                 400 


Glu Asp Val Gly Phe Asn Thr Ile Pro Ala Cys Trp Trp Trp Gly Thr 
                405                 410                 415     


Val Ser Met Thr Thr Val Gly Tyr Gly Asp Val Val Pro Val Thr Val 
            420                 425                 430         


Ala Gly Lys Leu Ala Ala Ser Gly Cys Ile Leu Gly Gly Ile Leu Val 
        435                 440                 445             


Val Ala Leu Pro Ile Thr Ile Ile Phe Asn Lys Phe Ser His Phe Tyr 
    450                 455                 460                 


Arg Arg Gln Lys Ala Leu Glu Ala Ala Val Arg Asn Ser Asn His Gln 
465                 470                 475                 480 


Glu Phe Glu Asp Leu Leu Ser Ser Ile Asp Gly Val Ser Glu Ala Ser 
                485                 490                 495     


Leu Glu Thr Ser Arg Glu Thr Ser Gln Glu Gly Gln Ser Ala Asp Leu 
            500                 505                 510         


Glu Ser Gln Ala Pro Ser Glu Pro Pro His Pro Gln Met Tyr 
        515                 520                 525     


<210>  2606
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  2606

Met Val Phe Gly Glu Phe Phe His Arg Pro Gly Gln Asp Glu Glu Leu 
1               5                   10                  15      


Val Asn Leu Asn Val Gly Gly Phe Lys Gln Ser Val Asp Gln Ser Thr 
            20                  25                  30          


Leu Leu Arg Phe Pro His Thr Arg Leu Gly Lys Leu Leu Thr Cys His 
        35                  40                  45              


Ser Glu Glu Ala Ile Leu Glu Leu Cys Asp Asp Tyr Ser Val Ala Asp 
    50                  55                  60                  


Lys Glu Tyr Tyr Phe Asp Arg Asn Pro Ser Leu Phe Arg Tyr Val Leu 
65                  70                  75                  80  


Asn Phe Tyr Tyr Thr Gly Lys Leu His Val Met Glu Glu Leu Cys Val 
                85                  90                  95      


Phe Ser Phe Cys Gln Glu Ile Glu Tyr Trp Gly Ile Asn Glu Leu Phe 
            100                 105                 110         


Ile Asp Ser Cys Cys Ser Asn Arg Tyr Gln Glu Arg Lys Glu Glu Asn 
        115                 120                 125             


His Glu Lys Asp Trp Asp Gln Lys Ser His Asp Val Ser Thr Asp Ser 
    130                 135                 140                 


Ser Phe Glu Glu Ser Ser Leu Phe Glu Lys Glu Leu Glu Lys Phe Asp 
145                 150                 155                 160 


Thr Leu Arg Phe Gly Gln Leu Arg Lys Lys Ile Trp Ile Arg Met Glu 
                165                 170                 175     


Asn Pro Ala Tyr Cys Leu Ser Ala Lys Leu Ile Ala Ile Ser Ser Leu 
            180                 185                 190         


Ser Val Val Leu Ala Ser Ile Val Ala Met Cys Val His Ser Met Ser 
        195                 200                 205             


Glu Phe Gln Asn Glu Asp Gly Glu Val Asp Asp Pro Val Leu Glu Gly 
    210                 215                 220                 


Val Glu Ile Ala Cys Ile Ala Trp Phe Thr Gly Glu Leu Ala Val Arg 
225                 230                 235                 240 


Leu Ala Ala Ala Pro Cys Gln Lys Lys Phe Trp Lys Asn Pro Leu Asn 
                245                 250                 255     


Ile Ile Asp Phe Val Ser Ile Ile Pro Phe Tyr Ala Thr Leu Ala Val 
            260                 265                 270         


Asp Thr Lys Glu Glu Glu Ser Glu Asp Ile Glu Asn Met Gly Lys Val 
        275                 280                 285             


Val Gln Ile Leu Arg Leu Met Arg Ile Phe Arg Ile Leu Lys Leu Ala 
    290                 295                 300                 


Arg His Ser Val Gly Leu Arg Ser Leu Gly Ala Thr Leu Arg His Ser 
305                 310                 315                 320 


Tyr His Glu Val Gly Leu Leu Leu Leu Phe Leu Ser Val Gly Ile Ser 
                325                 330                 335     


Ile Phe Ser Val Leu Ile Tyr Ser Val Glu Lys Asp Asp His Thr Ser 
            340                 345                 350         


Ser Leu Thr Ser Ile Pro Ile Cys Trp Trp Trp Ala Thr Ile Ser Met 
        355                 360                 365             


Thr Thr Val Gly Tyr Gly Asp Thr His Pro Val Thr Leu Ala Gly Lys 
    370                 375                 380                 


Leu Ile Ala Ser Thr Cys Ile Ile Cys Gly Ile Leu Val Val Ala Leu 
385                 390                 395                 400 


Pro Ile Thr Ile Ile Phe Asn Lys Phe Ser Lys Tyr Tyr Gln Lys Gln 
                405                 410                 415     


Lys Asp Ile Asp Val Asp Gln Cys Ser Glu Asp Ala Pro Glu Lys Cys 
            420                 425                 430         


His Glu Leu Pro Tyr Phe Asn Ile Arg Asp Ile Tyr Ala Gln Arg Met 
        435                 440                 445             


His Thr Phe Ile Thr Ser Leu Ser Ser Val Gly Ile Val Val Ser Asp 
    450                 455                 460                 


Pro Asp Ser Thr Asp Ala Ser Ser Ile Glu Asp Asn Glu Asp Ile Cys 
465                 470                 475                 480 


Asn Thr Thr Ser Leu Glu Asn Cys Thr Ala Lys 
                485                 490     


<210>  2607
<211>  1356
<212>  PRT
<213>  Homo sapiens

<400>  2607

Met Gln Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val Glu 
1               5                   10                  15      


Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro 
            20                  25                  30          


Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr 
        35                  40                  45              


Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro 
    50                  55                  60                  


Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser 
65                  70                  75                  80  


Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn 
                85                  90                  95      


Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser 
            100                 105                 110         


Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser 
        115                 120                 125             


Val Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys 
    130                 135                 140                 


Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser 
145                 150                 155                 160 


Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg 
                165                 170                 175     


Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile 
            180                 185                 190         


Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser 
        195                 200                 205             


Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr 
    210                 215                 220                 


Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu 
225                 230                 235                 240 


Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile 
                245                 250                 255     


Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu 
            260                 265                 270         


Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe 
        275                 280                 285             


Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu 
    290                 295                 300                 


Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr 
305                 310                 315                 320 


Phe Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met 
                325                 330                 335     


Glu Ser Leu Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro Ala 
            340                 345                 350         


Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly 
        355                 360                 365             


Ile Pro Leu Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr 
    370                 375                 380                 


Ile Met Glu Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile Leu 
385                 390                 395                 400 


Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val 
                405                 410                 415     


Val Tyr Val Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val 
            420                 425                 430         


Asp Ser Tyr Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr 
        435                 440                 445             


Ala Ile Pro Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu 
    450                 455                 460                 


Glu Cys Ala Asn Glu Pro Ser Gln Ala Val Ser Val Thr Asn Pro Tyr 
465                 470                 475                 480 


Pro Cys Glu Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys 
                485                 490                 495     


Ile Glu Val Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys 
            500                 505                 510         


Thr Val Ser Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr 
        515                 520                 525             


Lys Cys Glu Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser 
    530                 535                 540                 


Phe His Val Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln 
545                 550                 555                 560 


Pro Thr Glu Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg Ser 
                565                 570                 575     


Thr Phe Glu Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro 
            580                 585                 590         


Ile His Val Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr 
        595                 600                 605             


Leu Trp Lys Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile 
    610                 615                 620                 


Leu Ile Met Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr 
625                 630                 635                 640 


Val Cys Leu Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val 
                645                 650                 655     


Arg Gln Leu Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn 
            660                 665                 670         


Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys 
        675                 680                 685             


Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn 
    690                 695                 700                 


Glu Thr Leu Val Glu Asp Ser Gly Ile Val Leu Lys Asp Gly Asn Arg 
705                 710                 715                 720 


Asn Leu Thr Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr Thr 
                725                 730                 735     


Cys Gln Ala Cys Ser Val Leu Gly Cys Ala Lys Val Glu Ala Phe Phe 
            740                 745                 750         


Ile Ile Glu Gly Ala Gln Glu Lys Thr Asn Leu Glu Ile Ile Ile Leu 
        755                 760                 765             


Val Gly Thr Ala Val Ile Ala Met Phe Phe Trp Leu Leu Leu Val Ile 
    770                 775                 780                 


Ile Leu Arg Thr Val Lys Arg Ala Asn Gly Gly Glu Leu Lys Thr Gly 
785                 790                 795                 800 


Tyr Leu Ser Ile Val Met Asp Pro Asp Glu Leu Pro Leu Asp Glu His 
                805                 810                 815     


Cys Glu Arg Leu Pro Tyr Asp Ala Ser Lys Trp Glu Phe Pro Arg Asp 
            820                 825                 830         


Arg Leu Lys Leu Gly Lys Pro Leu Gly Arg Gly Ala Phe Gly Gln Val 
        835                 840                 845             


Ile Glu Ala Asp Ala Phe Gly Ile Asp Lys Thr Ala Thr Cys Arg Thr 
    850                 855                 860                 


Val Ala Val Lys Met Leu Lys Glu Gly Ala Thr His Ser Glu His Arg 
865                 870                 875                 880 


Ala Leu Met Ser Glu Leu Lys Ile Leu Ile His Ile Gly His His Leu 
                885                 890                 895     


Asn Val Val Asn Leu Leu Gly Ala Cys Thr Lys Pro Gly Gly Pro Leu 
            900                 905                 910         


Met Val Ile Val Glu Phe Cys Lys Phe Gly Asn Leu Ser Thr Tyr Leu 
        915                 920                 925             


Arg Ser Lys Arg Asn Glu Phe Val Pro Tyr Lys Thr Lys Gly Ala Arg 
    930                 935                 940                 


Phe Arg Gln Gly Lys Asp Tyr Val Gly Ala Ile Pro Val Asp Leu Lys 
945                 950                 955                 960 


Arg Arg Leu Asp Ser Ile Thr Ser Ser Gln Ser Ser Ala Ser Ser Gly 
                965                 970                 975     


Phe Val Glu Glu Lys Ser Leu Ser Asp Val Glu Glu Glu Glu Ala Pro 
            980                 985                 990         


Glu Asp Leu Tyr Lys Asp Phe Leu  Thr Leu Glu His Leu  Ile Cys Tyr 
        995                 1000                 1005             


Ser Phe  Gln Val Ala Lys Gly  Met Glu Phe Leu Ala  Ser Arg Lys 
    1010                 1015                 1020             


Cys Ile  His Arg Asp Leu Ala  Ala Arg Asn Ile Leu  Leu Ser Glu 
    1025                 1030                 1035             


Lys Asn  Val Val Lys Ile Cys  Asp Phe Gly Leu Ala  Arg Asp Ile 
    1040                 1045                 1050             


Tyr Lys  Asp Pro Asp Tyr Val  Arg Lys Gly Asp Ala  Arg Leu Pro 
    1055                 1060                 1065             


Leu Lys  Trp Met Ala Pro Glu  Thr Ile Phe Asp Arg  Val Tyr Thr 
    1070                 1075                 1080             


Ile Gln  Ser Asp Val Trp Ser  Phe Gly Val Leu Leu  Trp Glu Ile 
    1085                 1090                 1095             


Phe Ser  Leu Gly Ala Ser Pro  Tyr Pro Gly Val Lys  Ile Asp Glu 
    1100                 1105                 1110             


Glu Phe  Cys Arg Arg Leu Lys  Glu Gly Thr Arg Met  Arg Ala Pro 
    1115                 1120                 1125             


Asp Tyr  Thr Thr Pro Glu Met  Tyr Gln Thr Met Leu  Asp Cys Trp 
    1130                 1135                 1140             


His Gly  Glu Pro Ser Gln Arg  Pro Thr Phe Ser Glu  Leu Val Glu 
    1145                 1150                 1155             


His Leu  Gly Asn Leu Leu Gln  Ala Asn Ala Gln Gln  Asp Gly Lys 
    1160                 1165                 1170             


Asp Tyr  Ile Val Leu Pro Ile  Ser Glu Thr Leu Ser  Met Glu Glu 
    1175                 1180                 1185             


Asp Ser  Gly Leu Ser Leu Pro  Thr Ser Pro Val Ser  Cys Met Glu 
    1190                 1195                 1200             


Glu Glu  Glu Val Cys Asp Pro  Lys Phe His Tyr Asp  Asn Thr Ala 
    1205                 1210                 1215             


Gly Ile  Ser Gln Tyr Leu Gln  Asn Ser Lys Arg Lys  Ser Arg Pro 
    1220                 1225                 1230             


Val Ser  Val Lys Thr Phe Glu  Asp Ile Pro Leu Glu  Glu Pro Glu 
    1235                 1240                 1245             


Val Lys  Val Ile Pro Asp Asp  Asn Gln Thr Asp Ser  Gly Met Val 
    1250                 1255                 1260             


Leu Ala  Ser Glu Glu Leu Lys  Thr Leu Glu Asp Arg  Thr Lys Leu 
    1265                 1270                 1275             


Ser Pro  Ser Phe Gly Gly Met  Val Pro Ser Lys Ser  Arg Glu Ser 
    1280                 1285                 1290             


Val Ala  Ser Glu Gly Ser Asn  Gln Thr Ser Gly Tyr  Gln Ser Gly 
    1295                 1300                 1305             


Tyr His  Ser Asp Asp Thr Asp  Thr Thr Val Tyr Ser  Ser Glu Glu 
    1310                 1315                 1320             


Ala Glu  Leu Leu Lys Leu Ile  Glu Ile Gly Val Gln  Thr Gly Ser 
    1325                 1330                 1335             


Thr Ala  Gln Ile Leu Gln Pro  Asp Ser Gly Thr Thr  Leu Ser Ser 
    1340                 1345                 1350             


Pro Pro  Val 
    1355     


<210>  2608
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  2608

Met Ser Met Ser Pro Thr Val Ile Ile Leu Ala Cys Leu Gly Phe Phe 
1               5                   10                  15      


Leu Asp Gln Ser Val Trp Ala His Val Gly Gly Gln Asp Lys Pro Phe 
            20                  25                  30          


Cys Ser Ala Trp Pro Ser Ala Val Val Pro Gln Gly Gly His Val Thr 
        35                  40                  45              


Leu Arg Cys His Tyr Arg Arg Gly Phe Asn Ile Phe Thr Leu Tyr Lys 
    50                  55                  60                  


Lys Asp Gly Val Pro Val Pro Glu Leu Tyr Asn Arg Ile Phe Trp Asn 
65                  70                  75                  80  


Ser Phe Leu Ile Ser Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg 
                85                  90                  95      


Cys Arg Gly Phe His Pro His Ser Pro Thr Glu Trp Ser Ala Pro Ser 
            100                 105                 110         


Asn Pro Leu Val Ile Met Val Thr Gly Leu Tyr Glu Lys Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Pro Gly Pro Thr Val Arg Ala Gly Glu Asn Val Thr Leu 
    130                 135                 140                 


Ser Cys Ser Ser Gln Ser Ser Phe Asp Ile Tyr His Leu Ser Arg Glu 
145                 150                 155                 160 


Gly Glu Ala His Glu Leu Arg Leu Pro Ala Val Pro Ser Ile Asn Gly 
                165                 170                 175     


Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly Glu Thr 
            180                 185                 190         


Tyr Arg Cys Phe Gly Ser Phe His Gly Ser Pro Tyr Glu Trp Ser Asp 
        195                 200                 205             


Pro Ser Asp Pro Leu Pro Val Ser Val Thr Gly Asn Pro Ser Ser Ser 
    210                 215                 220                 


Trp Pro Ser Pro Thr Glu Pro Ser Phe Lys Thr Gly Ile Ala Arg His 
225                 230                 235                 240 


Leu His Ala Val Ile Arg Tyr Ser Val Ala Ile Ile Leu Phe Thr Ile 
                245                 250                 255     


Leu Pro Phe Phe Leu Leu His Arg Trp Cys Ser Lys Lys Lys Asn Ala 
            260                 265                 270         


Ala Val Met Asn Gln Glu Pro Ala Gly His Arg Thr Val Asn Arg Glu 
        275                 280                 285             


Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln Leu Asp 
    290                 295                 300                 


His Cys Ile Phe Thr Gln Arg Lys Ile Thr Gly Pro Ser Gln Arg Ser 
305                 310                 315                 320 


Lys Arg Pro Ser Thr Asp Thr Ser Val Cys Ile Glu Leu Pro Asn Ala 
                325                 330                 335     


Glu Pro Arg Ala Leu Ser Pro Ala His Glu His His Ser Gln Ala Leu 
            340                 345                 350         


Met Gly Ser Ser Arg Glu Thr Thr Ala Leu Ser Gln Thr Gln Leu Ala 
        355                 360                 365             


Ser Ser Asn Val Pro Ala Ala Gly Ile 
    370                 375         


<210>  2609
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  2609

Met Asp Gln Gln Ala Ile Tyr Ala Glu Leu Asn Leu Pro Thr Asp Ser 
1               5                   10                  15      


Gly Pro Glu Ser Ser Ser Pro Ser Ser Leu Pro Arg Asp Val Cys Gln 
            20                  25                  30          


Gly Ser Pro Trp His Gln Phe Ala Leu Lys Leu Ser Cys Ala Gly Ile 
        35                  40                  45              


Ile Leu Leu Val Leu Val Val Thr Gly Leu Ser Val Ser Val Thr Ser 
    50                  55                  60                  


Leu Ile Gln Lys Ser Ser Ile Glu Lys Cys Ser Val Asp Ile Gln Gln 
65                  70                  75                  80  


Ser Arg Asn Lys Thr Thr Glu Arg Pro Gly Leu Leu Asn Cys Pro Ile 
                85                  90                  95      


Tyr Trp Gln Gln Leu Arg Glu Lys Cys Leu Leu Phe Ser His Thr Val 
            100                 105                 110         


Asn Pro Trp Asn Asn Ser Leu Ala Asp Cys Ser Thr Lys Glu Ser Ser 
        115                 120                 125             


Leu Leu Leu Ile Arg Asp Lys Asp Glu Leu Ile His Thr Gln Asn Leu 
    130                 135                 140                 


Ile Arg Asp Lys Ala Ile Leu Phe Trp Ile Gly Leu Asn Phe Ser Leu 
145                 150                 155                 160 


Ser Glu Lys Asn Trp Lys Trp Ile Asn Gly Ser Phe Leu Asn Ser Asn 
                165                 170                 175     


Asp Leu Glu Ile Arg Gly Asp Ala Lys Glu Asn Ser Cys Ile Ser Ile 
            180                 185                 190         


Ser Gln Thr Ser Val Tyr Ser Glu Tyr Cys Ser Thr Glu Ile Arg Trp 
        195                 200                 205             


Ile Cys Gln Lys Glu Leu Thr Pro Val Arg Asn Lys Val Tyr Pro Asp 
    210                 215                 220                 


Ser 
225 


<210>  2610
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  2610

Met Ser Lys Gln Arg Gly Thr Phe Ser Glu Val Ser Leu Ala Gln Asp 
1               5                   10                  15      


Pro Lys Trp Gln Gln Arg Lys Pro Lys Gly Asn Lys Ser Ser Ile Ser 
            20                  25                  30          


Gly Thr Glu Gln Glu Ile Phe Gln Val Glu Leu Asn Leu Gln Asn Ala 
        35                  40                  45              


Ser Leu Asn His Gln Gly Ile Asp Lys Ile Tyr Asp Cys Gln Gly Leu 
    50                  55                  60                  


Leu Pro Pro Pro Glu Lys Leu Thr Ala Glu Val Leu Gly Ile Ile Cys 
65                  70                  75                  80  


Ile Val Leu Met Ala Thr Val Leu Lys Thr Ile Val Leu Ile Pro Phe 
                85                  90                  95      


Leu Glu Gln Asn Asn Ser Ser Pro Asn Ala Arg Thr Gln Lys Ala Arg 
            100                 105                 110         


His Cys Gly His Cys Pro Glu Glu Trp Ile Thr Tyr Ser Asn Ser Cys 
        115                 120                 125             


Tyr Tyr Ile Gly Lys Glu Arg Arg Thr Trp Glu Glu Ser Leu Gln Ala 
    130                 135                 140                 


Cys Ala Ser Lys Asn Ser Ser Ser Leu Leu Cys Ile Asp Asn Glu Glu 
145                 150                 155                 160 


Glu Met Lys Phe Leu Ala Ser Ile Leu Pro Ser Ser Trp Ile Gly Val 
                165                 170                 175     


Phe Arg Asn Ser Ser His His Pro Trp Val Thr Ile Asn Gly Leu Ala 
            180                 185                 190         


Phe Lys His Glu Ile Lys Asp Ser Asp His Ala Glu Arg Asn Cys Ala 
        195                 200                 205             


Met Leu His Val Arg Gly Leu Ile Ser Asp Gln Cys Gly Ser Ser Arg 
    210                 215                 220                 


Ile Ile Arg Arg Gly Phe Ile Met Leu Thr Arg Leu Val Leu Asn Ser 
225                 230                 235                 240 


<210>  2611
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  2611

Met Ala Val Phe Lys Thr Thr Leu Trp Arg Leu Ile Ser Gly Thr Leu 
1               5                   10                  15      


Gly Ile Ile Cys Leu Ser Leu Met Ala Thr Leu Gly Ile Leu Leu Lys 
            20                  25                  30          


Asn Ser Phe Thr Lys Leu Ser Ile Glu Pro Ala Phe Thr Pro Gly Pro 
        35                  40                  45              


Asn Ile Glu Leu Gln Lys Asp Ser Asp Cys Cys Ser Cys Gln Glu Lys 
    50                  55                  60                  


Trp Val Gly Tyr Arg Cys Asn Cys Tyr Phe Ile Ser Ser Glu Gln Lys 
65                  70                  75                  80  


Thr Trp Asn Glu Ser Arg His Leu Cys Ala Ser Gln Lys Ser Ser Leu 
                85                  90                  95      


Leu Gln Leu Gln Asn Thr Asp Glu Leu Asp Phe Met Ser Ser Ser Gln 
            100                 105                 110         


Gln Phe Tyr Trp Ile Gly Leu Ser Tyr Ser Glu Glu His Thr Ala Trp 
        115                 120                 125             


Leu Trp Glu Asn Gly Ser Ala Leu Ser Gln Tyr Leu Phe Pro Ser Phe 
    130                 135                 140                 


Glu Thr Phe Asn Thr Lys Asn Cys Ile Ala Tyr Asn Pro Asn Gly Asn 
145                 150                 155                 160 


Ala Leu Asp Glu Ser Cys Glu Asp Lys Asn Arg Tyr Ile Cys Lys Gln 
                165                 170                 175     


Gln Leu Ile 
            


<210>  2612
<211>  287
<212>  PRT
<213>  Homo sapiens

<400>  2612

Met Ser Pro His Pro Thr Ala Leu Leu Gly Leu Val Leu Cys Leu Ala 
1               5                   10                  15      


Gln Thr Ile His Thr Gln Glu Glu Asp Leu Pro Arg Pro Ser Ile Ser 
            20                  25                  30          


Ala Glu Pro Gly Thr Val Ile Pro Leu Gly Ser His Val Thr Phe Val 
        35                  40                  45              


Cys Arg Gly Pro Val Gly Val Gln Thr Phe Arg Leu Glu Arg Asp Ser 
    50                  55                  60                  


Arg Ser Thr Tyr Asn Asp Thr Glu Asp Val Ser Gln Ala Ser Pro Ser 
65                  70                  75                  80  


Glu Ser Glu Ala Arg Phe Arg Ile Asp Ser Val Arg Glu Gly Asn Ala 
                85                  90                  95      


Gly Leu Tyr Arg Cys Ile Tyr Tyr Lys Pro Pro Lys Trp Ser Glu Gln 
            100                 105                 110         


Ser Asp Tyr Leu Glu Leu Leu Val Lys Glu Ser Ser Gly Gly Pro Asp 
        115                 120                 125             


Ser Pro Asp Thr Glu Pro Gly Ser Ser Ala Gly Pro Thr Gln Arg Pro 
    130                 135                 140                 


Ser Asp Asn Ser His Asn Glu His Ala Pro Ala Ser Gln Gly Leu Lys 
145                 150                 155                 160 


Ala Glu His Leu Tyr Ile Leu Ile Gly Val Ser Val Val Phe Leu Phe 
                165                 170                 175     


Cys Leu Leu Leu Leu Val Leu Phe Cys Leu His Arg Gln Asn Gln Ile 
            180                 185                 190         


Lys Gln Gly Pro Pro Arg Ser Lys Asp Glu Glu Gln Lys Pro Gln Gln 
        195                 200                 205             


Arg Pro Asp Leu Ala Val Asp Val Leu Glu Arg Thr Ala Asp Lys Ala 
    210                 215                 220                 


Thr Val Asn Gly Leu Pro Glu Lys Asp Arg Glu Thr Asp Thr Ser Ala 
225                 230                 235                 240 


Leu Ala Ala Gly Ser Ser Gln Glu Val Thr Tyr Ala Gln Leu Asp His 
                245                 250                 255     


Trp Ala Leu Thr Gln Arg Thr Ala Arg Ala Val Ser Pro Gln Ser Thr 
            260                 265                 270         


Lys Pro Met Ala Glu Ser Ile Thr Tyr Ala Ala Val Ala Arg His 
        275                 280                 285         


<210>  2613
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  2613

Met Val Cys Phe Arg Leu Phe Pro Val Pro Gly Ser Gly Leu Val Leu 
1               5                   10                  15      


Val Cys Leu Val Leu Gly Ala Val Arg Ser Tyr Ala Leu Glu Leu Asn 
            20                  25                  30          


Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln Met 
        35                  40                  45              


Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr Val 
    50                  55                  60                  


Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys Gly 
65                  70                  75                  80  


Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly Phe 
                85                  90                  95      


Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile Asp 
            100                 105                 110         


Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro Asp 
        115                 120                 125             


Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile Arg 
    130                 135                 140                 


Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu Glu 
145                 150                 155                 160 


Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala Phe 
                165                 170                 175     


Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys Asp 
            180                 185                 190         


Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser Pro 
        195                 200                 205             


Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr Ser 
    210                 215                 220                 


Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu Gln 
225                 230                 235                 240 


Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn Pro 
                245                 250                 255     


Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu Leu 
            260                 265                 270         


Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala Val 
        275                 280                 285             


Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met Tyr 
    290                 295                 300                 


Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser Tyr 
305                 310                 315                 320 


Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln Thr 
                325                 330                 335     


Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg Val 
            340                 345                 350         


Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Asp Cys 
        355                 360                 365             


Ser Ala Asp Asp Asp Asn Phe Leu Val Pro Ile Ala Val Gly Ala Ala 
    370                 375                 380                 


Leu Ala Gly Val Leu Ile Leu Val Leu Leu Ala Tyr Phe Ile Gly Leu 
385                 390                 395                 400 


Lys His His His Ala Gly Tyr Glu Gln Phe 
                405                 410 


<210>  2614
<211>  615
<212>  PRT
<213>  Homo sapiens

<400>  2614

Met Pro Ser Arg Lys Phe Ala Asp Gly Glu Val Val Arg Gly Arg Trp 
1               5                   10                  15      


Pro Gly Ser Ser Leu Tyr Tyr Glu Val Glu Ile Leu Ser His Asp Ser 
            20                  25                  30          


Thr Ser Gln Leu Tyr Thr Val Lys Tyr Lys Asp Gly Thr Glu Leu Glu 
        35                  40                  45              


Leu Lys Glu Asn Asp Ile Lys Pro Leu Thr Ser Phe Arg Gln Arg Lys 
    50                  55                  60                  


Gly Gly Ser Thr Ser Ser Ser Pro Ser Arg Arg Arg Gly Ser Arg Ser 
65                  70                  75                  80  


Arg Ser Arg Ser Arg Ser Pro Gly Arg Pro Pro Lys Ser Ala Arg Arg 
                85                  90                  95      


Ser Ala Ser Ala Ser His Gln Ala Asp Ile Lys Glu Ala Arg Arg Glu 
            100                 105                 110         


Val Glu Val Lys Leu Thr Pro Leu Ile Leu Lys Pro Phe Gly Asn Ser 
        115                 120                 125             


Ile Ser Arg Tyr Asn Gly Glu Pro Glu His Ile Glu Arg Asn Asp Ala 
    130                 135                 140                 


Pro His Lys Asn Thr Gln Glu Lys Phe Ser Leu Ser Gln Glu Ser Ser 
145                 150                 155                 160 


Tyr Ile Ala Thr Gln Tyr Ser Leu Arg Pro Arg Arg Glu Glu Val Lys 
                165                 170                 175     


Leu Lys Glu Ile Asp Ser Lys Glu Glu Lys Tyr Val Ala Lys Glu Leu 
            180                 185                 190         


Ala Val Arg Thr Phe Glu Val Thr Pro Ile Arg Ala Lys Asp Leu Glu 
        195                 200                 205             


Phe Gly Gly Val Pro Gly Val Phe Leu Ile Met Phe Gly Leu Pro Val 
    210                 215                 220                 


Phe Leu Phe Leu Leu Leu Leu Met Cys Lys Gln Lys Asp Pro Ser Leu 
225                 230                 235                 240 


Leu Asn Phe Pro Pro Pro Leu Pro Ala Leu Tyr Glu Leu Trp Glu Thr 
                245                 250                 255     


Arg Val Phe Gly Val Tyr Leu Leu Trp Phe Leu Ile Gln Val Leu Phe 
            260                 265                 270         


Tyr Leu Leu Pro Ile Gly Lys Val Val Glu Gly Thr Pro Leu Ile Asp 
        275                 280                 285             


Gly Arg Arg Leu Lys Tyr Arg Leu Asn Gly Phe Tyr Ala Phe Ile Leu 
    290                 295                 300                 


Thr Ser Ala Val Ile Gly Thr Ser Leu Phe Gln Gly Val Glu Phe His 
305                 310                 315                 320 


Tyr Val Tyr Ser His Phe Leu Gln Phe Ala Leu Ala Ala Thr Val Phe 
                325                 330                 335     


Cys Val Val Leu Ser Val Tyr Leu Tyr Met Arg Ser Leu Lys Ala Pro 
            340                 345                 350         


Arg Asn Asp Leu Ser Pro Ala Ser Ser Gly Asn Ala Val Tyr Asp Phe 
        355                 360                 365             


Phe Ile Gly Arg Glu Leu Asn Pro Arg Ile Gly Thr Phe Asp Leu Lys 
    370                 375                 380                 


Tyr Phe Cys Glu Leu Arg Pro Gly Leu Ile Gly Trp Val Val Ile Asn 
385                 390                 395                 400 


Leu Val Met Leu Leu Ala Glu Met Lys Ile Gln Asp Arg Ala Val Pro 
                405                 410                 415     


Ser Leu Ala Met Ile Leu Val Asn Ser Phe Gln Leu Leu Tyr Val Val 
            420                 425                 430         


Asp Ala Leu Trp Asn Glu Glu Ala Leu Leu Thr Thr Met Asp Ile Ile 
        435                 440                 445             


His Asp Gly Phe Gly Phe Met Leu Ala Phe Gly Asp Leu Val Trp Val 
    450                 455                 460                 


Pro Phe Ile Tyr Ser Phe Gln Ala Phe Tyr Leu Val Ser His Pro Asn 
465                 470                 475                 480 


Glu Val Ser Trp Pro Met Ala Ser Leu Ile Ile Val Leu Lys Leu Cys 
                485                 490                 495     


Gly Tyr Val Ile Phe Arg Gly Ala Asn Ser Gln Lys Asn Ala Phe Arg 
            500                 505                 510         


Lys Asn Pro Ser Asp Pro Lys Leu Ala His Leu Lys Thr Ile His Thr 
        515                 520                 525             


Ser Thr Gly Lys Asn Leu Leu Val Ser Gly Trp Trp Gly Phe Val Arg 
    530                 535                 540                 


His Pro Asn Tyr Leu Gly Asp Leu Ile Met Ala Leu Ala Trp Ser Leu 
545                 550                 555                 560 


Pro Cys Gly Phe Asn His Ile Leu Pro Tyr Phe Tyr Ile Ile Tyr Phe 
                565                 570                 575     


Thr Met Leu Leu Val His Arg Glu Ala Arg Asp Glu Tyr His Cys Lys 
            580                 585                 590         


Lys Lys Tyr Gly Val Ala Trp Glu Lys Tyr Cys Gln Arg Val Pro Tyr 
        595                 600                 605             


Arg Ile Phe Pro Tyr Ile Tyr 
    610                 615 


<210>  2615
<211>  1927
<212>  PRT
<213>  Homo sapiens

<400>  2615

Met Glu Leu Ser Trp His Val Val Phe Ile Ala Leu Leu Ser Phe Ser 
1               5                   10                  15      


Cys Trp Gly Ser Asp Trp Glu Ser Asp Arg Asn Phe Ile Ser Thr Ala 
            20                  25                  30          


Gly Pro Leu Thr Asn Asp Leu Leu His Asn Leu Ser Gly Leu Leu Gly 
        35                  40                  45              


Asp Gln Ser Ser Asn Phe Val Ala Gly Asp Lys Asp Met Tyr Val Cys 
    50                  55                  60                  


His Gln Pro Leu Pro Thr Phe Leu Pro Glu Tyr Phe Ser Ser Leu His 
65                  70                  75                  80  


Ala Ser Gln Ile Thr His Tyr Lys Val Phe Leu Ser Trp Ala Gln Leu 
                85                  90                  95      


Leu Pro Ala Gly Ser Thr Gln Asn Pro Asp Glu Lys Thr Val Gln Cys 
            100                 105                 110         


Tyr Arg Arg Leu Leu Lys Ala Leu Lys Thr Ala Arg Leu Gln Pro Met 
        115                 120                 125             


Val Ile Leu His His Gln Thr Leu Pro Ala Ser Thr Leu Arg Arg Thr 
    130                 135                 140                 


Glu Ala Phe Ala Asp Leu Phe Ala Asp Tyr Ala Thr Phe Ala Phe His 
145                 150                 155                 160 


Ser Phe Gly Asp Leu Val Gly Ile Trp Phe Thr Phe Ser Asp Leu Glu 
                165                 170                 175     


Glu Val Ile Lys Glu Leu Pro His Gln Glu Ser Arg Ala Ser Gln Leu 
            180                 185                 190         


Gln Thr Leu Ser Asp Ala His Arg Lys Ala Tyr Glu Ile Tyr His Glu 
        195                 200                 205             


Ser Tyr Ala Phe Gln Gly Gly Lys Leu Ser Val Val Leu Arg Ala Glu 
    210                 215                 220                 


Asp Ile Pro Glu Leu Leu Leu Glu Pro Pro Ile Ser Ala Leu Ala Gln 
225                 230                 235                 240 


Asp Thr Val Asp Phe Leu Ser Leu Asp Leu Ser Tyr Glu Cys Gln Asn 
                245                 250                 255     


Glu Ala Ser Leu Arg Gln Lys Leu Ser Lys Leu Gln Thr Ile Glu Pro 
            260                 265                 270         


Lys Val Lys Val Phe Ile Phe Asn Leu Lys Leu Pro Asp Cys Pro Ser 
        275                 280                 285             


Thr Met Lys Asn Pro Ala Ser Leu Leu Phe Ser Leu Phe Glu Ala Ile 
    290                 295                 300                 


Asn Lys Asp Gln Val Leu Thr Ile Gly Phe Asp Ile Asn Glu Phe Leu 
305                 310                 315                 320 


Ser Cys Ser Ser Ser Ser Lys Lys Ser Met Ser Cys Ser Leu Thr Gly 
                325                 330                 335     


Ser Leu Ala Leu Gln Pro Asp Gln Gln Gln Asp His Glu Thr Thr Asp 
            340                 345                 350         


Ser Ser Pro Ala Ser Ala Tyr Gln Arg Ile Trp Glu Ala Phe Ala Asn 
        355                 360                 365             


Gln Ser Arg Ala Glu Arg Asp Ala Phe Leu Gln Asp Thr Phe Pro Glu 
    370                 375                 380                 


Gly Phe Leu Trp Gly Ala Ser Thr Gly Ala Phe Asn Val Glu Gly Gly 
385                 390                 395                 400 


Trp Ala Glu Gly Gly Arg Gly Val Ser Ile Trp Asp Pro Arg Arg Pro 
                405                 410                 415     


Leu Asn Thr Thr Glu Gly Gln Ala Thr Leu Glu Val Ala Ser Asp Ser 
            420                 425                 430         


Tyr His Lys Val Ala Ser Asp Val Ala Leu Leu Cys Gly Leu Arg Ala 
        435                 440                 445             


Gln Val Tyr Lys Phe Ser Ile Ser Trp Ser Arg Ile Phe Pro Met Gly 
    450                 455                 460                 


His Gly Ser Ser Pro Ser Leu Pro Gly Val Ala Tyr Tyr Asn Lys Leu 
465                 470                 475                 480 


Ile Asp Arg Leu Gln Asp Ala Gly Ile Glu Pro Met Ala Thr Leu Phe 
                485                 490                 495     


His Trp Asp Leu Pro Gln Ala Leu Gln Asp His Gly Gly Trp Gln Asn 
            500                 505                 510         


Glu Ser Val Val Asp Ala Phe Leu Asp Tyr Ala Ala Phe Cys Phe Ser 
        515                 520                 525             


Thr Phe Gly Asp Arg Val Lys Leu Trp Val Thr Phe His Glu Pro Trp 
    530                 535                 540                 


Val Met Ser Tyr Ala Gly Tyr Gly Thr Gly Gln His Pro Pro Gly Ile 
545                 550                 555                 560 


Ser Asp Pro Gly Val Ala Ser Phe Lys Val Ala His Leu Val Leu Lys 
                565                 570                 575     


Ala His Ala Arg Thr Trp His His Tyr Asn Ser His His Arg Pro Gln 
            580                 585                 590         


Gln Gln Gly His Val Gly Ile Val Leu Asn Ser Asp Trp Ala Glu Pro 
        595                 600                 605             


Leu Ser Pro Glu Arg Pro Glu Asp Leu Arg Ala Ser Glu Arg Phe Leu 
    610                 615                 620                 


His Phe Met Leu Gly Trp Phe Ala His Pro Val Phe Val Asp Gly Asp 
625                 630                 635                 640 


Tyr Pro Ala Thr Leu Arg Thr Gln Ile Gln Gln Met Asn Arg Gln Cys 
                645                 650                 655     


Ser His Pro Val Ala Gln Leu Pro Glu Phe Thr Glu Ala Glu Lys Gln 
            660                 665                 670         


Leu Leu Lys Gly Ser Ala Asp Phe Leu Gly Leu Ser His Tyr Thr Ser 
        675                 680                 685             


Arg Leu Ile Ser Asn Ala Pro Gln Asn Thr Cys Ile Pro Ser Tyr Asp 
    690                 695                 700                 


Thr Ile Gly Gly Phe Ser Gln His Val Asn His Val Trp Pro Gln Thr 
705                 710                 715                 720 


Ser Ser Ser Trp Ile Arg Val Val Pro Trp Gly Ile Arg Arg Leu Leu 
                725                 730                 735     


Gln Phe Val Ser Leu Glu Tyr Thr Arg Gly Lys Val Pro Ile Tyr Leu 
            740                 745                 750         


Ala Gly Asn Gly Met Pro Ile Gly Glu Ser Glu Asn Leu Phe Asp Asp 
        755                 760                 765             


Ser Leu Arg Val Asp Tyr Phe Asn Gln Tyr Ile Asn Glu Val Leu Lys 
    770                 775                 780                 


Ala Ile Lys Glu Asp Ser Val Asp Val Arg Ser Tyr Ile Ala Arg Ser 
785                 790                 795                 800 


Leu Ile Asp Gly Phe Glu Gly Pro Ser Gly Tyr Ser Gln Arg Phe Gly 
                805                 810                 815     


Leu His His Val Asn Phe Ser Asp Ser Ser Lys Ser Arg Thr Pro Arg 
            820                 825                 830         


Lys Ser Ala Tyr Phe Phe Thr Ser Ile Ile Glu Lys Asn Gly Phe Leu 
        835                 840                 845             


Thr Lys Gly Ala Lys Arg Leu Leu Pro Pro Asn Thr Val Asn Leu Pro 
    850                 855                 860                 


Ser Lys Val Arg Ala Phe Thr Phe Pro Ser Glu Val Pro Ser Lys Ala 
865                 870                 875                 880 


Lys Val Val Trp Glu Lys Phe Ser Ser Gln Pro Lys Phe Glu Arg Asp 
                885                 890                 895     


Leu Phe Tyr His Gly Thr Phe Arg Asp Asp Phe Leu Trp Gly Val Ser 
            900                 905                 910         


Ser Ser Ala Tyr Gln Ile Glu Gly Ala Trp Asp Ala Asp Gly Lys Gly 
        915                 920                 925             


Pro Ser Ile Trp Asp Asn Phe Thr His Thr Pro Gly Ser Asn Val Lys 
    930                 935                 940                 


Asp Asn Ala Thr Gly Asp Ile Ala Cys Asp Ser Tyr His Gln Leu Asp 
945                 950                 955                 960 


Ala Asp Leu Asn Met Leu Arg Ala Leu Lys Val Lys Ala Tyr Arg Phe 
                965                 970                 975     


Ser Ile Ser Trp Ser Arg Ile Phe Pro Thr Gly Arg Asn Ser Ser Ile 
            980                 985                 990         


Asn Ser His Gly Val Asp Tyr Tyr  Asn Arg Leu Ile Asn  Gly Leu Val 
        995                 1000                 1005             


Ala Ser  Asn Ile Phe Pro Met  Val Thr Leu Phe His  Trp Asp Leu 
    1010                 1015                 1020             


Pro Gln  Ala Leu Gln Asp Ile  Gly Gly Trp Glu Asn  Pro Ala Leu 
    1025                 1030                 1035             


Ile Asp  Leu Phe Asp Ser Tyr  Ala Asp Phe Cys Phe  Gln Thr Phe 
    1040                 1045                 1050             


Gly Asp  Arg Val Lys Phe Trp  Met Thr Phe Asn Glu  Pro Met Tyr 
    1055                 1060                 1065             


Leu Ala  Trp Leu Gly Tyr Gly  Ser Gly Glu Phe Pro  Pro Gly Val 
    1070                 1075                 1080             


Lys Asp  Pro Gly Trp Ala Pro  Tyr Arg Ile Ala His  Ala Val Ile 
    1085                 1090                 1095             


Lys Ala  His Ala Arg Val Tyr  His Thr Tyr Asp Glu  Lys Tyr Arg 
    1100                 1105                 1110             


Gln Glu  Gln Lys Gly Val Ile  Ser Leu Ser Leu Ser  Thr His Trp 
    1115                 1120                 1125             


Ala Glu  Pro Lys Ser Pro Gly  Val Pro Arg Asp Val  Glu Ala Ala 
    1130                 1135                 1140             


Asp Arg  Met Leu Gln Phe Ser  Leu Gly Trp Phe Ala  His Pro Ile 
    1145                 1150                 1155             


Phe Arg  Asn Gly Asp Tyr Pro  Asp Thr Met Lys Trp  Lys Val Gly 
    1160                 1165                 1170             


Asn Arg  Ser Glu Leu Gln His  Leu Ala Thr Ser Arg  Leu Pro Ser 
    1175                 1180                 1185             


Phe Thr  Glu Glu Glu Lys Arg  Phe Ile Arg Ala Thr  Ala Asp Val 
    1190                 1195                 1200             


Phe Cys  Leu Asn Thr Tyr Tyr  Ser Arg Ile Val Gln  His Lys Thr 
    1205                 1210                 1215             


Pro Arg  Leu Asn Pro Pro Ser  Tyr Glu Asp Asp Gln  Glu Met Ala 
    1220                 1225                 1230             


Glu Glu  Glu Asp Pro Ser Trp  Pro Ser Thr Ala Met  Asn Arg Ala 
    1235                 1240                 1245             


Ala Pro  Trp Gly Thr Arg Arg  Leu Leu Asn Trp Ile  Lys Glu Glu 
    1250                 1255                 1260             


Tyr Gly  Asp Ile Pro Ile Tyr  Ile Thr Glu Asn Gly  Val Gly Leu 
    1265                 1270                 1275             


Thr Asn  Pro Asn Thr Glu Asp  Thr Asp Arg Ile Phe  Tyr His Lys 
    1280                 1285                 1290             


Thr Tyr  Ile Asn Glu Ala Leu  Lys Ala Tyr Arg Leu  Asp Gly Ile 
    1295                 1300                 1305             


Asp Leu  Arg Gly Tyr Val Ala  Trp Ser Leu Met Asp  Asn Phe Glu 
    1310                 1315                 1320             


Trp Leu  Asn Gly Tyr Thr Val  Lys Phe Gly Leu Tyr  His Val Asp 
    1325                 1330                 1335             


Phe Asn  Asn Thr Asn Arg Pro  Arg Thr Ala Arg Ala  Ser Ala Arg 
    1340                 1345                 1350             


Tyr Tyr  Thr Glu Val Ile Thr  Asn Asn Gly Met Pro  Leu Ala Arg 
    1355                 1360                 1365             


Glu Asp  Glu Phe Leu Tyr Gly  Arg Phe Pro Glu Gly  Phe Ile Trp 
    1370                 1375                 1380             


Ser Ala  Ala Ser Ala Ala Tyr  Gln Ile Glu Gly Ala  Trp Arg Ala 
    1385                 1390                 1395             


Asp Gly  Lys Gly Leu Ser Ile  Trp Asp Thr Phe Ser  His Thr Pro 
    1400                 1405                 1410             


Leu Arg  Val Glu Asn Asp Ala  Ile Gly Asp Val Ala  Cys Asp Ser 
    1415                 1420                 1425             


Tyr His  Lys Ile Ala Glu Asp  Leu Val Thr Leu Gln  Asn Leu Gly 
    1430                 1435                 1440             


Val Ser  His Tyr Arg Phe Ser  Ile Ser Trp Ser Arg  Ile Leu Pro 
    1445                 1450                 1455             


Asp Gly  Thr Thr Arg Tyr Ile  Asn Glu Ala Gly Leu  Asn Tyr Tyr 
    1460                 1465                 1470             


Val Arg  Leu Ile Asp Thr Leu  Leu Ala Ala Ser Ile  Gln Pro Gln 
    1475                 1480                 1485             


Val Thr  Ile Tyr His Trp Asp  Leu Pro Gln Thr Leu  Gln Asp Val 
    1490                 1495                 1500             


Gly Gly  Trp Glu Asn Glu Thr  Ile Val Gln Arg Phe  Lys Glu Tyr 
    1505                 1510                 1515             


Ala Asp  Val Leu Phe Gln Arg  Leu Gly Asp Lys Val  Lys Phe Trp 
    1520                 1525                 1530             


Ile Thr  Leu Asn Glu Pro Phe  Val Ile Ala Tyr Gln  Gly Tyr Gly 
    1535                 1540                 1545             


Tyr Gly  Thr Ala Ala Pro Gly  Val Ser Asn Arg Pro  Gly Thr Ala 
    1550                 1555                 1560             


Pro Tyr  Ile Val Gly His Asn  Leu Ile Lys Ala His  Ala Glu Ala 
    1565                 1570                 1575             


Trp His  Leu Tyr Asn Asp Val  Tyr Arg Ala Ser Gln  Gly Gly Val 
    1580                 1585                 1590             


Ile Ser  Ile Thr Ile Ser Ser  Asp Trp Ala Glu Pro  Arg Asp Pro 
    1595                 1600                 1605             


Ser Asn  Gln Glu Asp Val Glu  Ala Ala Arg Arg Tyr  Val Gln Phe 
    1610                 1615                 1620             


Met Gly  Gly Trp Phe Ala His  Pro Ile Phe Lys Asn  Gly Asp Tyr 
    1625                 1630                 1635             


Asn Glu  Val Met Lys Thr Arg  Ile Arg Asp Arg Ser  Leu Ala Ala 
    1640                 1645                 1650             


Gly Leu  Asn Lys Ser Arg Leu  Pro Glu Phe Thr Glu  Ser Glu Lys 
    1655                 1660                 1665             


Arg Arg  Ile Asn Gly Thr Tyr  Asp Phe Phe Gly Phe  Asn His Tyr 
    1670                 1675                 1680             


Thr Thr  Val Leu Ala Tyr Asn  Leu Asn Tyr Ala Thr  Ala Ile Ser 
    1685                 1690                 1695             


Ser Phe  Asp Ala Asp Arg Gly  Val Ala Ser Ile Ala  Asp Arg Ser 
    1700                 1705                 1710             


Trp Pro  Asp Ser Gly Ser Phe  Trp Leu Lys Met Thr  Pro Phe Gly 
    1715                 1720                 1725             


Phe Arg  Arg Ile Leu Asn Trp  Leu Lys Glu Glu Tyr  Asn Asp Pro 
    1730                 1735                 1740             


Pro Ile  Tyr Val Thr Glu Asn  Gly Val Ser Gln Arg  Glu Glu Thr 
    1745                 1750                 1755             


Asp Leu  Asn Asp Thr Ala Arg  Ile Tyr Tyr Leu Arg  Thr Tyr Ile 
    1760                 1765                 1770             


Asn Glu  Ala Leu Lys Ala Val  Gln Asp Lys Val Asp  Leu Arg Gly 
    1775                 1780                 1785             


Tyr Thr  Val Trp Ser Ala Met  Asp Asn Phe Glu Trp  Ala Thr Gly 
    1790                 1795                 1800             


Phe Ser  Glu Arg Phe Gly Leu  His Phe Val Asn Tyr  Ser Asp Pro 
    1805                 1810                 1815             


Ser Leu  Pro Arg Ile Pro Lys  Ala Ser Ala Lys Phe  Tyr Ala Ser 
    1820                 1825                 1830             


Val Val  Arg Cys Asn Gly Phe  Pro Asp Pro Ala Thr  Gly Pro His 
    1835                 1840                 1845             


Ala Cys  Leu His Gln Pro Asp  Ala Gly Pro Thr Ile  Ser Pro Val 
    1850                 1855                 1860             


Arg Gln  Glu Glu Val Gln Phe  Leu Gly Leu Met Leu  Gly Thr Thr 
    1865                 1870                 1875             


Glu Ala  Gln Thr Ala Leu Tyr  Val Leu Phe Ser Leu  Val Leu Leu 
    1880                 1885                 1890             


Gly Val  Cys Gly Leu Ala Phe  Leu Ser Tyr Lys Tyr  Cys Lys Arg 
    1895                 1900                 1905             


Ser Lys  Gln Gly Lys Thr Gln  Arg Ser Gln Gln Glu  Leu Ser Pro 
    1910                 1915                 1920             


Val Ser  Ser Phe 
    1925         


<210>  2616
<211>  1165
<212>  PRT
<213>  Homo sapiens

<400>  2616

Met Ile Cys Gln Lys Phe Cys Val Val Leu Leu His Trp Glu Phe Ile 
1               5                   10                  15      


Tyr Val Ile Thr Ala Phe Asn Leu Ser Tyr Pro Ile Thr Pro Trp Arg 
            20                  25                  30          


Phe Lys Leu Ser Cys Met Pro Pro Asn Ser Thr Tyr Asp Tyr Phe Leu 
        35                  40                  45              


Leu Pro Ala Gly Leu Ser Lys Asn Thr Ser Asn Ser Asn Gly His Tyr 
    50                  55                  60                  


Glu Thr Ala Val Glu Pro Lys Phe Asn Ser Ser Gly Thr His Phe Ser 
65                  70                  75                  80  


Asn Leu Ser Lys Thr Thr Phe His Cys Cys Phe Arg Ser Glu Gln Asp 
                85                  90                  95      


Arg Asn Cys Ser Leu Cys Ala Asp Asn Ile Glu Gly Lys Thr Phe Val 
            100                 105                 110         


Ser Thr Val Asn Ser Leu Val Phe Gln Gln Ile Asp Ala Asn Trp Asn 
        115                 120                 125             


Ile Gln Cys Trp Leu Lys Gly Asp Leu Lys Leu Phe Ile Cys Tyr Val 
    130                 135                 140                 


Glu Ser Leu Phe Lys Asn Leu Phe Arg Asn Tyr Asn Tyr Lys Val His 
145                 150                 155                 160 


Leu Leu Tyr Val Leu Pro Glu Val Leu Glu Asp Ser Pro Leu Val Pro 
                165                 170                 175     


Gln Lys Gly Ser Phe Gln Met Val His Cys Asn Cys Ser Val His Glu 
            180                 185                 190         


Cys Cys Glu Cys Leu Val Pro Val Pro Thr Ala Lys Leu Asn Asp Thr 
        195                 200                 205             


Leu Leu Met Cys Leu Lys Ile Thr Ser Gly Gly Val Ile Phe Gln Ser 
    210                 215                 220                 


Pro Leu Met Ser Val Gln Pro Ile Asn Met Val Lys Pro Asp Pro Pro 
225                 230                 235                 240 


Leu Gly Leu His Met Glu Ile Thr Asp Asp Gly Asn Leu Lys Ile Ser 
                245                 250                 255     


Trp Ser Ser Pro Pro Leu Val Pro Phe Pro Leu Gln Tyr Gln Val Lys 
            260                 265                 270         


Tyr Ser Glu Asn Ser Thr Thr Val Ile Arg Glu Ala Asp Lys Ile Val 
        275                 280                 285             


Ser Ala Thr Ser Leu Leu Val Asp Ser Ile Leu Pro Gly Ser Ser Tyr 
    290                 295                 300                 


Glu Val Gln Val Arg Gly Lys Arg Leu Asp Gly Pro Gly Ile Trp Ser 
305                 310                 315                 320 


Asp Trp Ser Thr Pro Arg Val Phe Thr Thr Gln Asp Val Ile Tyr Phe 
                325                 330                 335     


Pro Pro Lys Ile Leu Thr Ser Val Gly Ser Asn Val Ser Phe His Cys 
            340                 345                 350         


Ile Tyr Lys Lys Glu Asn Lys Ile Val Pro Ser Lys Glu Ile Val Trp 
        355                 360                 365             


Trp Met Asn Leu Ala Glu Lys Ile Pro Gln Ser Gln Tyr Asp Val Val 
    370                 375                 380                 


Ser Asp His Val Ser Lys Val Thr Phe Phe Asn Leu Asn Glu Thr Lys 
385                 390                 395                 400 


Pro Arg Gly Lys Phe Thr Tyr Asp Ala Val Tyr Cys Cys Asn Glu His 
                405                 410                 415     


Glu Cys His His Arg Tyr Ala Glu Leu Tyr Val Ile Asp Val Asn Ile 
            420                 425                 430         


Asn Ile Ser Cys Glu Thr Asp Gly Tyr Leu Thr Lys Met Thr Cys Arg 
        435                 440                 445             


Trp Ser Thr Ser Thr Ile Gln Ser Leu Ala Glu Ser Thr Leu Gln Leu 
    450                 455                 460                 


Arg Tyr His Arg Ser Ser Leu Tyr Cys Ser Asp Ile Pro Ser Ile His 
465                 470                 475                 480 


Pro Ile Ser Glu Pro Lys Asp Cys Tyr Leu Gln Ser Asp Gly Phe Tyr 
                485                 490                 495     


Glu Cys Ile Phe Gln Pro Ile Phe Leu Leu Ser Gly Tyr Thr Met Trp 
            500                 505                 510         


Ile Arg Ile Asn His Ser Leu Gly Ser Leu Asp Ser Pro Pro Thr Cys 
        515                 520                 525             


Val Leu Pro Asp Ser Val Val Lys Pro Leu Pro Pro Ser Ser Val Lys 
    530                 535                 540                 


Ala Glu Ile Thr Ile Asn Ile Gly Leu Leu Lys Ile Ser Trp Glu Lys 
545                 550                 555                 560 


Pro Val Phe Pro Glu Asn Asn Leu Gln Phe Gln Ile Arg Tyr Gly Leu 
                565                 570                 575     


Ser Gly Lys Glu Val Gln Trp Lys Met Tyr Glu Val Tyr Asp Ala Lys 
            580                 585                 590         


Ser Lys Ser Val Ser Leu Pro Val Pro Asp Leu Cys Ala Val Tyr Ala 
        595                 600                 605             


Val Gln Val Arg Cys Lys Arg Leu Asp Gly Leu Gly Tyr Trp Ser Asn 
    610                 615                 620                 


Trp Ser Asn Pro Ala Tyr Thr Val Val Met Asp Ile Lys Val Pro Met 
625                 630                 635                 640 


Arg Gly Pro Glu Phe Trp Arg Ile Ile Asn Gly Asp Thr Met Lys Lys 
                645                 650                 655     


Glu Lys Asn Val Thr Leu Leu Trp Lys Pro Leu Met Lys Asn Asp Ser 
            660                 665                 670         


Leu Cys Ser Val Gln Arg Tyr Val Ile Asn His His Thr Ser Cys Asn 
        675                 680                 685             


Gly Thr Trp Ser Glu Asp Val Gly Asn His Thr Lys Phe Thr Phe Leu 
    690                 695                 700                 


Trp Thr Glu Gln Ala His Thr Val Thr Val Leu Ala Ile Asn Ser Ile 
705                 710                 715                 720 


Gly Ala Ser Val Ala Asn Phe Asn Leu Thr Phe Ser Trp Pro Met Ser 
                725                 730                 735     


Lys Val Asn Ile Val Gln Ser Leu Ser Ala Tyr Pro Leu Asn Ser Ser 
            740                 745                 750         


Cys Val Ile Val Ser Trp Ile Leu Ser Pro Ser Asp Tyr Lys Leu Met 
        755                 760                 765             


Tyr Phe Ile Ile Glu Trp Lys Asn Leu Asn Glu Asp Gly Glu Ile Lys 
    770                 775                 780                 


Trp Leu Arg Ile Ser Ser Ser Val Lys Lys Tyr Tyr Ile His Asp His 
785                 790                 795                 800 


Phe Ile Pro Ile Glu Lys Tyr Gln Phe Ser Leu Tyr Pro Ile Phe Met 
                805                 810                 815     


Glu Gly Val Gly Lys Pro Lys Ile Ile Asn Ser Phe Thr Gln Asp Asp 
            820                 825                 830         


Ile Glu Lys His Gln Ser Asp Ala Gly Leu Tyr Val Ile Val Pro Val 
        835                 840                 845             


Ile Ile Ser Ser Ser Ile Leu Leu Leu Gly Thr Leu Leu Ile Ser His 
    850                 855                 860                 


Gln Arg Met Lys Lys Leu Phe Trp Glu Asp Val Pro Asn Pro Lys Asn 
865                 870                 875                 880 


Cys Ser Trp Ala Gln Gly Leu Asn Phe Gln Lys Pro Glu Thr Phe Glu 
                885                 890                 895     


His Leu Phe Ile Lys His Thr Ala Ser Val Thr Cys Gly Pro Leu Leu 
            900                 905                 910         


Leu Glu Pro Glu Thr Ile Ser Glu Asp Ile Ser Val Asp Thr Ser Trp 
        915                 920                 925             


Lys Asn Lys Asp Glu Met Met Pro Thr Thr Val Val Ser Leu Leu Ser 
    930                 935                 940                 


Thr Thr Asp Leu Glu Lys Gly Ser Val Cys Ile Ser Asp Gln Phe Asn 
945                 950                 955                 960 


Ser Val Asn Phe Ser Glu Ala Glu Gly Thr Glu Val Thr Tyr Glu Asp 
                965                 970                 975     


Glu Ser Gln Arg Gln Pro Phe Val Lys Tyr Ala Thr Leu Ile Ser Asn 
            980                 985                 990         


Ser Lys Pro Ser Glu Thr Gly Glu  Glu Gln Gly Leu Ile  Asn Ser Ser 
        995                 1000                 1005             


Val Thr  Lys Cys Phe Ser Ser  Lys Asn Ser Pro Leu  Lys Asp Ser 
    1010                 1015                 1020             


Phe Ser  Asn Ser Ser Trp Glu  Ile Glu Ala Gln Ala  Phe Phe Ile 
    1025                 1030                 1035             


Leu Ser  Asp Gln His Pro Asn  Ile Ile Ser Pro His  Leu Thr Phe 
    1040                 1045                 1050             


Ser Glu  Gly Leu Asp Glu Leu  Leu Lys Leu Glu Gly  Asn Phe Pro 
    1055                 1060                 1065             


Glu Glu  Asn Asn Asp Lys Lys  Ser Ile Tyr Tyr Leu  Gly Val Thr 
    1070                 1075                 1080             


Ser Ile  Lys Lys Arg Glu Ser  Gly Val Leu Leu Thr  Asp Lys Ser 
    1085                 1090                 1095             


Arg Val  Ser Cys Pro Phe Pro  Ala Pro Cys Leu Phe  Thr Asp Ile 
    1100                 1105                 1110             


Arg Val  Leu Gln Asp Ser Cys  Ser His Phe Val Glu  Asn Asn Ile 
    1115                 1120                 1125             


Asn Leu  Gly Thr Ser Ser Lys  Lys Thr Phe Ala Ser  Tyr Met Pro 
    1130                 1135                 1140             


Gln Phe  Gln Thr Cys Ser Thr  Gln Thr His Lys Ile  Met Glu Asn 
    1145                 1150                 1155             


Lys Met  Cys Asp Leu Thr Val  
    1160                 1165 


<210>  2617
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  2617

Met Thr Pro Gly Arg Cys Cys Leu Ala Ala Asp Ile Gln Val Glu Thr 
1               5                   10                  15      


Phe Ile Phe Thr Asp Gly Glu Asp Glu Ala Leu Ala Arg His Thr Gly 
            20                  25                  30          


Asn Val Val Ile Thr Asn Cys Ser Ala Ala His Ser Arg Gln Ala Leu 
        35                  40                  45              


Ser Cys Lys Met Ala Val Glu Tyr Asp Arg Phe Ile Glu Ser Gly Arg 
    50                  55                  60                  


Lys Trp Phe Cys His Val Asp Asp Asp Asn Tyr Val Asn Leu Arg Ala 
65                  70                  75                  80  


Leu Leu Arg Leu Leu Ala Ser Tyr Pro His Thr Arg Asp Val Tyr Val 
                85                  90                  95      


Gly Lys Pro Ser Leu Asp Arg Pro Ile Gln Ala Met Glu Arg Val Ser 
            100                 105                 110         


Glu Asn Lys Val Arg Pro Val His Phe Trp Phe Ala Thr Gly Gly Ala 
        115                 120                 125             


Gly Phe Cys Ile Ser Arg Gly Leu Ala Leu Lys Met Ser Pro Trp Ala 
    130                 135                 140                 


Ser Gly Gly His Phe Met Asn Thr Ala Glu Arg Ile Arg Leu Pro Asp 
145                 150                 155                 160 


Asp Cys Thr Ile Gly Tyr Ile Val Glu Ala Leu Leu Gly Val Pro Leu 
                165                 170                 175     


Ile Arg Ser Gly Leu Phe His Ser His Leu Glu Asn Leu Gln Gln Val 
            180                 185                 190         


Pro Thr Ser Glu Leu His Glu Gln Val Thr Leu Ser Tyr Gly Met Phe 
        195                 200                 205             


Glu Asn Lys Arg Asn Ala Val His Val Lys Gly Pro Phe Ser Val Glu 
    210                 215                 220                 


Ala Asp Pro Ser Arg Phe Arg Ser Ile His Cys His Leu Tyr Pro Asp 
225                 230                 235                 240 


Thr Pro Trp Cys Pro Arg Thr Ala Ile Phe 
                245                 250 


<210>  2618
<211>  1097
<212>  PRT
<213>  Homo sapiens

<400>  2618

Met Met Asp Ile Tyr Val Cys Leu Lys Arg Pro Ser Trp Met Val Asp 
1               5                   10                  15      


Asn Lys Arg Met Arg Thr Ala Ser Asn Phe Gln Trp Leu Leu Ser Thr 
            20                  25                  30          


Phe Ile Leu Leu Tyr Leu Met Asn Gln Val Asn Ser Gln Lys Lys Gly 
        35                  40                  45              


Ala Pro His Asp Leu Lys Cys Val Thr Asn Asn Leu Gln Val Trp Asn 
    50                  55                  60                  


Cys Ser Trp Lys Ala Pro Ser Gly Thr Gly Arg Gly Thr Asp Tyr Glu 
65                  70                  75                  80  


Val Cys Ile Glu Asn Arg Ser Arg Ser Cys Tyr Gln Leu Glu Lys Thr 
                85                  90                  95      


Ser Ile Lys Ile Pro Ala Leu Ser His Gly Asp Tyr Glu Ile Thr Ile 
            100                 105                 110         


Asn Ser Leu His Asp Phe Gly Ser Ser Thr Ser Lys Phe Thr Leu Asn 
        115                 120                 125             


Glu Gln Asn Val Ser Leu Ile Pro Asp Thr Pro Glu Ile Leu Asn Leu 
    130                 135                 140                 


Ser Ala Asp Phe Ser Thr Ser Thr Leu Tyr Leu Lys Trp Asn Asp Arg 
145                 150                 155                 160 


Gly Ser Val Phe Pro His Arg Ser Asn Val Ile Trp Glu Ile Lys Val 
                165                 170                 175     


Leu Arg Lys Glu Ser Met Glu Leu Val Lys Leu Val Thr His Asn Thr 
            180                 185                 190         


Thr Leu Asn Gly Lys Asp Thr Leu His His Trp Ser Trp Ala Ser Asp 
        195                 200                 205             


Met Pro Leu Glu Cys Ala Ile His Phe Val Glu Ile Arg Cys Tyr Ile 
    210                 215                 220                 


Asp Asn Leu His Phe Ser Gly Leu Glu Glu Trp Ser Asp Trp Ser Pro 
225                 230                 235                 240 


Val Lys Asn Ile Ser Trp Ile Pro Asp Ser Gln Thr Lys Val Phe Pro 
                245                 250                 255     


Gln Asp Lys Val Ile Leu Val Gly Ser Asp Ile Thr Phe Cys Cys Val 
            260                 265                 270         


Ser Gln Glu Lys Val Leu Ser Ala Leu Ile Gly His Thr Asn Cys Pro 
        275                 280                 285             


Leu Ile His Leu Asp Gly Glu Asn Val Ala Ile Lys Ile Arg Asn Ile 
    290                 295                 300                 


Ser Val Ser Ala Ser Ser Gly Thr Asn Val Val Phe Thr Thr Glu Asp 
305                 310                 315                 320 


Asn Ile Phe Gly Thr Val Ile Phe Ala Gly Tyr Pro Pro Asp Thr Pro 
                325                 330                 335     


Gln Gln Leu Asn Cys Glu Thr His Asp Leu Lys Glu Ile Ile Cys Ser 
            340                 345                 350         


Trp Asn Pro Gly Arg Val Thr Ala Leu Val Gly Pro Arg Ala Thr Ser 
        355                 360                 365             


Tyr Thr Leu Val Glu Ser Phe Ser Gly Lys Tyr Val Arg Leu Lys Arg 
    370                 375                 380                 


Ala Glu Ala Pro Thr Asn Glu Ser Tyr Gln Leu Leu Phe Gln Met Leu 
385                 390                 395                 400 


Pro Asn Gln Glu Ile Tyr Asn Phe Thr Leu Asn Ala His Asn Pro Leu 
                405                 410                 415     


Gly Arg Ser Gln Ser Thr Ile Leu Val Asn Ile Thr Glu Lys Val Tyr 
            420                 425                 430         


Pro His Thr Pro Thr Ser Phe Lys Val Lys Asp Ile Asn Ser Thr Ala 
        435                 440                 445             


Val Lys Leu Ser Trp His Leu Pro Gly Asn Phe Ala Lys Ile Asn Phe 
    450                 455                 460                 


Leu Cys Glu Ile Glu Ile Lys Lys Ser Asn Ser Val Gln Glu Gln Arg 
465                 470                 475                 480 


Asn Val Thr Ile Lys Gly Val Glu Asn Ser Ser Tyr Leu Val Ala Leu 
                485                 490                 495     


Asp Lys Leu Asn Pro Tyr Thr Leu Tyr Thr Phe Arg Ile Arg Cys Ser 
            500                 505                 510         


Thr Glu Thr Phe Trp Lys Trp Ser Lys Trp Ser Asn Lys Lys Gln His 
        515                 520                 525             


Leu Thr Thr Glu Ala Ser Pro Ser Lys Gly Pro Asp Thr Trp Arg Glu 
    530                 535                 540                 


Trp Ser Ser Asp Gly Lys Asn Leu Ile Ile Tyr Trp Lys Pro Leu Pro 
545                 550                 555                 560 


Ile Asn Glu Ala Asn Gly Lys Ile Leu Ser Tyr Asn Val Ser Cys Ser 
                565                 570                 575     


Ser Asp Glu Glu Thr Gln Ser Leu Ser Glu Ile Pro Asp Pro Gln His 
            580                 585                 590         


Lys Ala Glu Ile Arg Leu Asp Lys Asn Asp Tyr Ile Ile Ser Val Val 
        595                 600                 605             


Ala Lys Asn Ser Val Gly Ser Ser Pro Pro Ser Lys Ile Ala Ser Met 
    610                 615                 620                 


Glu Ile Pro Asn Asp Asp Leu Lys Ile Glu Gln Val Val Gly Met Gly 
625                 630                 635                 640 


Lys Gly Ile Leu Leu Thr Trp His Tyr Asp Pro Asn Met Thr Cys Asp 
                645                 650                 655     


Tyr Val Ile Lys Trp Cys Asn Ser Ser Arg Ser Glu Pro Cys Leu Met 
            660                 665                 670         


Asp Trp Arg Lys Val Pro Ser Asn Ser Thr Glu Thr Val Ile Glu Ser 
        675                 680                 685             


Asp Glu Phe Arg Pro Gly Ile Arg Tyr Asn Phe Phe Leu Tyr Gly Cys 
    690                 695                 700                 


Arg Asn Gln Gly Tyr Gln Leu Leu Arg Ser Met Ile Gly Tyr Ile Glu 
705                 710                 715                 720 


Glu Leu Ala Pro Ile Val Ala Pro Asn Phe Thr Val Glu Asp Thr Ser 
                725                 730                 735     


Ala Asp Ser Ile Leu Val Lys Trp Glu Asp Ile Pro Val Glu Glu Leu 
            740                 745                 750         


Arg Gly Phe Leu Arg Gly Tyr Leu Phe Tyr Phe Gly Lys Gly Glu Arg 
        755                 760                 765             


Asp Thr Ser Lys Met Arg Val Leu Glu Ser Gly Arg Ser Asp Ile Lys 
    770                 775                 780                 


Val Lys Asn Ile Thr Asp Ile Ser Gln Lys Thr Leu Arg Ile Ala Asp 
785                 790                 795                 800 


Leu Gln Gly Lys Thr Ser Tyr His Leu Val Leu Arg Ala Tyr Thr Asp 
                805                 810                 815     


Gly Gly Val Gly Pro Glu Lys Ser Met Tyr Val Val Thr Lys Glu Asn 
            820                 825                 830         


Ser Val Gly Leu Ile Ile Ala Ile Leu Ile Pro Val Ala Val Ala Val 
        835                 840                 845             


Ile Val Gly Val Val Thr Ser Ile Leu Cys Tyr Arg Lys Arg Glu Trp 
    850                 855                 860                 


Ile Lys Glu Thr Phe Tyr Pro Asp Ile Pro Asn Pro Glu Asn Cys Lys 
865                 870                 875                 880 


Ala Leu Gln Phe Gln Lys Ser Val Cys Glu Gly Ser Ser Ala Leu Lys 
                885                 890                 895     


Thr Leu Glu Met Asn Pro Cys Thr Pro Asn Asn Val Glu Val Leu Glu 
            900                 905                 910         


Thr Arg Ser Ala Phe Pro Lys Ile Glu Asp Thr Glu Ile Ile Ser Pro 
        915                 920                 925             


Val Ala Glu Arg Pro Glu Asp Arg Ser Asp Ala Glu Pro Glu Asn His 
    930                 935                 940                 


Val Val Val Ser Tyr Cys Pro Pro Ile Ile Glu Glu Glu Ile Pro Asn 
945                 950                 955                 960 


Pro Ala Ala Asp Glu Ala Gly Gly Thr Ala Gln Val Ile Tyr Ile Asp 
                965                 970                 975     


Val Gln Ser Met Tyr Gln Pro Gln Ala Lys Pro Glu Glu Glu Gln Glu 
            980                 985                 990         


Asn Asp Pro Val Gly Gly Ala Gly  Tyr Lys Pro Gln Met  His Leu Pro 
        995                 1000                 1005             


Ile Asn  Ser Thr Val Glu Asp  Ile Ala Ala Glu Glu  Asp Leu Asp 
    1010                 1015                 1020             


Lys Thr  Ala Gly Tyr Arg Pro  Gln Ala Asn Val Asn  Thr Trp Asn 
    1025                 1030                 1035             


Leu Val  Ser Pro Asp Ser Pro  Arg Ser Ile Asp Ser  Asn Ser Glu 
    1040                 1045                 1050             


Ile Val  Ser Phe Gly Ser Pro  Cys Ser Ile Asn Ser  Arg Gln Phe 
    1055                 1060                 1065             


Leu Ile  Pro Pro Lys Asp Glu  Asp Ser Pro Lys Ser  Asn Gly Gly 
    1070                 1075                 1080             


Gly Trp  Ser Phe Thr Asn Phe  Phe Gln Asn Lys Pro  Asn Asp 
    1085                 1090                 1095         


<210>  2619
<211>  4544
<212>  PRT
<213>  Homo sapiens

<400>  2619

Met Leu Thr Pro Pro Leu Leu Leu Leu Leu Pro Leu Leu Ser Ala Leu 
1               5                   10                  15      


Val Ala Ala Ala Ile Asp Ala Pro Lys Thr Cys Ser Pro Lys Gln Phe 
            20                  25                  30          


Ala Cys Arg Asp Gln Ile Thr Cys Ile Ser Lys Gly Trp Arg Cys Asp 
        35                  40                  45              


Gly Glu Arg Asp Cys Pro Asp Gly Ser Asp Glu Ala Pro Glu Ile Cys 
    50                  55                  60                  


Pro Gln Ser Lys Ala Gln Arg Cys Gln Pro Asn Glu His Asn Cys Leu 
65                  70                  75                  80  


Gly Thr Glu Leu Cys Val Pro Met Ser Arg Leu Cys Asn Gly Val Gln 
                85                  90                  95      


Asp Cys Met Asp Gly Ser Asp Glu Gly Pro His Cys Arg Glu Leu Gln 
            100                 105                 110         


Gly Asn Cys Ser Arg Leu Gly Cys Gln His His Cys Val Pro Thr Leu 
        115                 120                 125             


Asp Gly Pro Thr Cys Tyr Cys Asn Ser Ser Phe Gln Leu Gln Ala Asp 
    130                 135                 140                 


Gly Lys Thr Cys Lys Asp Phe Asp Glu Cys Ser Val Tyr Gly Thr Cys 
145                 150                 155                 160 


Ser Gln Leu Cys Thr Asn Thr Asp Gly Ser Phe Ile Cys Gly Cys Val 
                165                 170                 175     


Glu Gly Tyr Leu Leu Gln Pro Asp Asn Arg Ser Cys Lys Ala Lys Asn 
            180                 185                 190         


Glu Pro Val Asp Arg Pro Pro Val Leu Leu Ile Ala Asn Ser Gln Asn 
        195                 200                 205             


Ile Leu Ala Thr Tyr Leu Ser Gly Ala Gln Val Ser Thr Ile Thr Pro 
    210                 215                 220                 


Thr Ser Thr Arg Gln Thr Thr Ala Met Asp Phe Ser Tyr Ala Asn Glu 
225                 230                 235                 240 


Thr Val Cys Trp Val His Val Gly Asp Ser Ala Ala Gln Thr Gln Leu 
                245                 250                 255     


Lys Cys Ala Arg Met Pro Gly Leu Lys Gly Phe Val Asp Glu His Thr 
            260                 265                 270         


Ile Asn Ile Ser Leu Ser Leu His His Val Glu Gln Met Ala Ile Asp 
        275                 280                 285             


Trp Leu Thr Gly Asn Phe Tyr Phe Val Asp Asp Ile Asp Asp Arg Ile 
    290                 295                 300                 


Phe Val Cys Asn Arg Asn Gly Asp Thr Cys Val Thr Leu Leu Asp Leu 
305                 310                 315                 320 


Glu Leu Tyr Asn Pro Lys Gly Ile Ala Leu Asp Pro Ala Met Gly Lys 
                325                 330                 335     


Val Phe Phe Thr Asp Tyr Gly Gln Ile Pro Lys Val Glu Arg Cys Asp 
            340                 345                 350         


Met Asp Gly Gln Asn Arg Thr Lys Leu Val Asp Ser Lys Ile Val Phe 
        355                 360                 365             


Pro His Gly Ile Thr Leu Asp Leu Val Ser Arg Leu Val Tyr Trp Ala 
    370                 375                 380                 


Asp Ala Tyr Leu Asp Tyr Ile Glu Val Val Asp Tyr Glu Gly Lys Gly 
385                 390                 395                 400 


Arg Gln Thr Ile Ile Gln Gly Ile Leu Ile Glu His Leu Tyr Gly Leu 
                405                 410                 415     


Thr Val Phe Glu Asn Tyr Leu Tyr Ala Thr Asn Ser Asp Asn Ala Asn 
            420                 425                 430         


Ala Gln Gln Lys Thr Ser Val Ile Arg Val Asn Arg Phe Asn Ser Thr 
        435                 440                 445             


Glu Tyr Gln Val Val Thr Arg Val Asp Lys Gly Gly Ala Leu His Ile 
    450                 455                 460                 


Tyr His Gln Arg Arg Gln Pro Arg Val Arg Ser His Ala Cys Glu Asn 
465                 470                 475                 480 


Asp Gln Tyr Gly Lys Pro Gly Gly Cys Ser Asp Ile Cys Leu Leu Ala 
                485                 490                 495     


Asn Ser His Lys Ala Arg Thr Cys Arg Cys Arg Ser Gly Phe Ser Leu 
            500                 505                 510         


Gly Ser Asp Gly Lys Ser Cys Lys Lys Pro Glu His Glu Leu Phe Leu 
        515                 520                 525             


Val Tyr Gly Lys Gly Arg Pro Gly Ile Ile Arg Gly Met Asp Met Gly 
    530                 535                 540                 


Ala Lys Val Pro Asp Glu His Met Ile Pro Ile Glu Asn Leu Met Asn 
545                 550                 555                 560 


Pro Arg Ala Leu Asp Phe His Ala Glu Thr Gly Phe Ile Tyr Phe Ala 
                565                 570                 575     


Asp Thr Thr Ser Tyr Leu Ile Gly Arg Gln Lys Ile Asp Gly Thr Glu 
            580                 585                 590         


Arg Glu Thr Ile Leu Lys Asp Gly Ile His Asn Val Glu Gly Val Ala 
        595                 600                 605             


Val Asp Trp Met Gly Asp Asn Leu Tyr Trp Thr Asp Asp Gly Pro Lys 
    610                 615                 620                 


Lys Thr Ile Ser Val Ala Arg Leu Glu Lys Ala Ala Gln Thr Arg Lys 
625                 630                 635                 640 


Thr Leu Ile Glu Gly Lys Met Thr His Pro Arg Ala Ile Val Val Asp 
                645                 650                 655     


Pro Leu Asn Gly Trp Met Tyr Trp Thr Asp Trp Glu Glu Asp Pro Lys 
            660                 665                 670         


Asp Ser Arg Arg Gly Arg Leu Glu Arg Ala Trp Met Asp Gly Ser His 
        675                 680                 685             


Arg Asp Ile Phe Val Thr Ser Lys Thr Val Leu Trp Pro Asn Gly Leu 
    690                 695                 700                 


Ser Leu Asp Ile Pro Ala Gly Arg Leu Tyr Trp Val Asp Ala Phe Tyr 
705                 710                 715                 720 


Asp Arg Ile Glu Thr Ile Leu Leu Asn Gly Thr Asp Arg Lys Ile Val 
                725                 730                 735     


Tyr Glu Gly Pro Glu Leu Asn His Ala Phe Gly Leu Cys His His Gly 
            740                 745                 750         


Asn Tyr Leu Phe Trp Thr Glu Tyr Arg Ser Gly Ser Val Tyr Arg Leu 
        755                 760                 765             


Glu Arg Gly Val Gly Gly Ala Pro Pro Thr Val Thr Leu Leu Arg Ser 
    770                 775                 780                 


Glu Arg Pro Pro Ile Phe Glu Ile Arg Met Tyr Asp Ala Gln Gln Gln 
785                 790                 795                 800 


Gln Val Gly Thr Asn Lys Cys Arg Val Asn Asn Gly Gly Cys Ser Ser 
                805                 810                 815     


Leu Cys Leu Ala Thr Pro Gly Ser Arg Gln Cys Ala Cys Ala Glu Asp 
            820                 825                 830         


Gln Val Leu Asp Ala Asp Gly Val Thr Cys Leu Ala Asn Pro Ser Tyr 
        835                 840                 845             


Val Pro Pro Pro Gln Cys Gln Pro Gly Glu Phe Ala Cys Ala Asn Ser 
    850                 855                 860                 


Arg Cys Ile Gln Glu Arg Trp Lys Cys Asp Gly Asp Asn Asp Cys Leu 
865                 870                 875                 880 


Asp Asn Ser Asp Glu Ala Pro Ala Leu Cys His Gln His Thr Cys Pro 
                885                 890                 895     


Ser Asp Arg Phe Lys Cys Glu Asn Asn Arg Cys Ile Pro Asn Arg Trp 
            900                 905                 910         


Leu Cys Asp Gly Asp Asn Asp Cys Gly Asn Ser Glu Asp Glu Ser Asn 
        915                 920                 925             


Ala Thr Cys Ser Ala Arg Thr Cys Pro Pro Asn Gln Phe Ser Cys Ala 
    930                 935                 940                 


Ser Gly Arg Cys Ile Pro Ile Ser Trp Thr Cys Asp Leu Asp Asp Asp 
945                 950                 955                 960 


Cys Gly Asp Arg Ser Asp Glu Ser Ala Ser Cys Ala Tyr Pro Thr Cys 
                965                 970                 975     


Phe Pro Leu Thr Gln Phe Thr Cys Asn Asn Gly Arg Cys Ile Asn Ile 
            980                 985                 990         


Asn Trp Arg Cys Asp Asn Asp Asn  Asp Cys Gly Asp Asn  Ser Asp Glu 
        995                 1000                 1005             


Ala Gly  Cys Ser His Ser Cys  Ser Ser Thr Gln Phe  Lys Cys Asn 
    1010                 1015                 1020             


Ser Gly  Arg Cys Ile Pro Glu  His Trp Thr Cys Asp  Gly Asp Asn 
    1025                 1030                 1035             


Asp Cys  Gly Asp Tyr Ser Asp  Glu Thr His Ala Asn  Cys Thr Asn 
    1040                 1045                 1050             


Gln Ala  Thr Arg Pro Pro Gly  Gly Cys His Thr Asp  Glu Phe Gln 
    1055                 1060                 1065             


Cys Arg  Leu Asp Gly Leu Cys  Ile Pro Leu Arg Trp  Arg Cys Asp 
    1070                 1075                 1080             


Gly Asp  Thr Asp Cys Met Asp  Ser Ser Asp Glu Lys  Ser Cys Glu 
    1085                 1090                 1095             


Gly Val  Thr His Val Cys Asp  Pro Ser Val Lys Phe  Gly Cys Lys 
    1100                 1105                 1110             


Asp Ser  Ala Arg Cys Ile Ser  Lys Ala Trp Val Cys  Asp Gly Asp 
    1115                 1120                 1125             


Asn Asp  Cys Glu Asp Asn Ser  Asp Glu Glu Asn Cys  Glu Ser Leu 
    1130                 1135                 1140             


Ala Cys  Arg Pro Pro Ser His  Pro Cys Ala Asn Asn  Thr Ser Val 
    1145                 1150                 1155             


Cys Leu  Pro Pro Asp Lys Leu  Cys Asp Gly Asn Asp  Asp Cys Gly 
    1160                 1165                 1170             


Asp Gly  Ser Asp Glu Gly Glu  Leu Cys Asp Gln Cys  Ser Leu Asn 
    1175                 1180                 1185             


Asn Gly  Gly Cys Ser His Asn  Cys Ser Val Ala Pro  Gly Glu Gly 
    1190                 1195                 1200             


Ile Val  Cys Ser Cys Pro Leu  Gly Met Glu Leu Gly  Pro Asp Asn 
    1205                 1210                 1215             


His Thr  Cys Gln Ile Gln Ser  Tyr Cys Ala Lys His  Leu Lys Cys 
    1220                 1225                 1230             


Ser Gln  Lys Cys Asp Gln Asn  Lys Phe Ser Val Lys  Cys Ser Cys 
    1235                 1240                 1245             


Tyr Glu  Gly Trp Val Leu Glu  Pro Asp Gly Glu Ser  Cys Arg Ser 
    1250                 1255                 1260             


Leu Asp  Pro Phe Lys Pro Phe  Ile Ile Phe Ser Asn  Arg His Glu 
    1265                 1270                 1275             


Ile Arg  Arg Ile Asp Leu His  Lys Gly Asp Tyr Ser  Val Leu Val 
    1280                 1285                 1290             


Pro Gly  Leu Arg Asn Thr Ile  Ala Leu Asp Phe His  Leu Ser Gln 
    1295                 1300                 1305             


Ser Ala  Leu Tyr Trp Thr Asp  Val Val Glu Asp Lys  Ile Tyr Arg 
    1310                 1315                 1320             


Gly Lys  Leu Leu Asp Asn Gly  Ala Leu Thr Ser Phe  Glu Val Val 
    1325                 1330                 1335             


Ile Gln  Tyr Gly Leu Ala Thr  Pro Glu Gly Leu Ala  Val Asp Trp 
    1340                 1345                 1350             


Ile Ala  Gly Asn Ile Tyr Trp  Val Glu Ser Asn Leu  Asp Gln Ile 
    1355                 1360                 1365             


Glu Val  Ala Lys Leu Asp Gly  Thr Leu Arg Thr Thr  Leu Leu Ala 
    1370                 1375                 1380             


Gly Asp  Ile Glu His Pro Arg  Ala Ile Ala Leu Asp  Pro Arg Asp 
    1385                 1390                 1395             


Gly Ile  Leu Phe Trp Thr Asp  Trp Asp Ala Ser Leu  Pro Arg Ile 
    1400                 1405                 1410             


Glu Ala  Ala Ser Met Ser Gly  Ala Gly Arg Arg Thr  Val His Arg 
    1415                 1420                 1425             


Glu Thr  Gly Ser Gly Gly Trp  Pro Asn Gly Leu Thr  Val Asp Tyr 
    1430                 1435                 1440             


Leu Glu  Lys Arg Ile Leu Trp  Ile Asp Ala Arg Ser  Asp Ala Ile 
    1445                 1450                 1455             


Tyr Ser  Ala Arg Tyr Asp Gly  Ser Gly His Met Glu  Val Leu Arg 
    1460                 1465                 1470             


Gly His  Glu Phe Leu Ser His  Pro Phe Ala Val Thr  Leu Tyr Gly 
    1475                 1480                 1485             


Gly Glu  Val Tyr Trp Thr Asp  Trp Arg Thr Asn Thr  Leu Ala Lys 
    1490                 1495                 1500             


Ala Asn  Lys Trp Thr Gly His  Asn Val Thr Val Val  Gln Arg Thr 
    1505                 1510                 1515             


Asn Thr  Gln Pro Phe Asp Leu  Gln Val Tyr His Pro  Ser Arg Gln 
    1520                 1525                 1530             


Pro Met  Ala Pro Asn Pro Cys  Glu Ala Asn Gly Gly  Gln Gly Pro 
    1535                 1540                 1545             


Cys Ser  His Leu Cys Leu Ile  Asn Tyr Asn Arg Thr  Val Ser Cys 
    1550                 1555                 1560             


Ala Cys  Pro His Leu Met Lys  Leu His Lys Asp Asn  Thr Thr Cys 
    1565                 1570                 1575             


Tyr Glu  Phe Lys Lys Phe Leu  Leu Tyr Ala Arg Gln  Met Glu Ile 
    1580                 1585                 1590             


Arg Gly  Val Asp Leu Asp Ala  Pro Tyr Tyr Asn Tyr  Ile Ile Ser 
    1595                 1600                 1605             


Phe Thr  Val Pro Asp Ile Asp  Asn Val Thr Val Leu  Asp Tyr Asp 
    1610                 1615                 1620             


Ala Arg  Glu Gln Arg Val Tyr  Trp Ser Asp Val Arg  Thr Gln Ala 
    1625                 1630                 1635             


Ile Lys  Arg Ala Phe Ile Asn  Gly Thr Gly Val Glu  Thr Val Val 
    1640                 1645                 1650             


Ser Ala  Asp Leu Pro Asn Ala  His Gly Leu Ala Val  Asp Trp Val 
    1655                 1660                 1665             


Ser Arg  Asn Leu Phe Trp Thr  Ser Tyr Asp Thr Asn  Lys Lys Gln 
    1670                 1675                 1680             


Ile Asn  Val Ala Arg Leu Asp  Gly Ser Phe Lys Asn  Ala Val Val 
    1685                 1690                 1695             


Gln Gly  Leu Glu Gln Pro His  Gly Leu Val Val His  Pro Leu Arg 
    1700                 1705                 1710             


Gly Lys  Leu Tyr Trp Thr Asp  Gly Asp Asn Ile Ser  Met Ala Asn 
    1715                 1720                 1725             


Met Asp  Gly Ser Asn Arg Thr  Leu Leu Phe Ser Gly  Gln Lys Gly 
    1730                 1735                 1740             


Pro Val  Gly Leu Ala Ile Asp  Phe Pro Glu Ser Lys  Leu Tyr Trp 
    1745                 1750                 1755             


Ile Ser  Ser Gly Asn His Thr  Ile Asn Arg Cys Asn  Leu Asp Gly 
    1760                 1765                 1770             


Ser Gly  Leu Glu Val Ile Asp  Ala Met Arg Ser Gln  Leu Gly Lys 
    1775                 1780                 1785             


Ala Thr  Ala Leu Ala Ile Met  Gly Asp Lys Leu Trp  Trp Ala Asp 
    1790                 1795                 1800             


Gln Val  Ser Glu Lys Met Gly  Thr Cys Ser Lys Ala  Asp Gly Ser 
    1805                 1810                 1815             


Gly Ser  Val Val Leu Arg Asn  Ser Thr Thr Leu Val  Met His Met 
    1820                 1825                 1830             


Lys Val  Tyr Asp Glu Ser Ile  Gln Leu Asp His Lys  Gly Thr Asn 
    1835                 1840                 1845             


Pro Cys  Ser Val Asn Asn Gly  Asp Cys Ser Gln Leu  Cys Leu Pro 
    1850                 1855                 1860             


Thr Ser  Glu Thr Thr Arg Ser  Cys Met Cys Thr Ala  Gly Tyr Ser 
    1865                 1870                 1875             


Leu Arg  Ser Gly Gln Gln Ala  Cys Glu Gly Val Gly  Ser Phe Leu 
    1880                 1885                 1890             


Leu Tyr  Ser Val His Glu Gly  Ile Arg Gly Ile Pro  Leu Asp Pro 
    1895                 1900                 1905             


Asn Asp  Lys Ser Asp Ala Leu  Val Pro Val Ser Gly  Thr Ser Leu 
    1910                 1915                 1920             


Ala Val  Gly Ile Asp Phe His  Ala Glu Asn Asp Thr  Ile Tyr Trp 
    1925                 1930                 1935             


Val Asp  Met Gly Leu Ser Thr  Ile Ser Arg Ala Lys  Arg Asp Gln 
    1940                 1945                 1950             


Thr Trp  Arg Glu Asp Val Val  Thr Asn Gly Ile Gly  Arg Val Glu 
    1955                 1960                 1965             


Gly Ile  Ala Val Asp Trp Ile  Ala Gly Asn Ile Tyr  Trp Thr Asp 
    1970                 1975                 1980             


Gln Gly  Phe Asp Val Ile Glu  Val Ala Arg Leu Asn  Gly Ser Phe 
    1985                 1990                 1995             


Arg Tyr  Val Val Ile Ser Gln  Gly Leu Asp Lys Pro  Arg Ala Ile 
    2000                 2005                 2010             


Thr Val  His Pro Glu Lys Gly  Tyr Leu Phe Trp Thr  Glu Trp Gly 
    2015                 2020                 2025             


Gln Tyr  Pro Arg Ile Glu Arg  Ser Arg Leu Asp Gly  Thr Glu Arg 
    2030                 2035                 2040             


Val Val  Leu Val Asn Val Ser  Ile Ser Trp Pro Asn  Gly Ile Ser 
    2045                 2050                 2055             


Val Asp  Tyr Gln Asp Gly Lys  Leu Tyr Trp Cys Asp  Ala Arg Thr 
    2060                 2065                 2070             


Asp Lys  Ile Glu Arg Ile Asp  Leu Glu Thr Gly Glu  Asn Arg Glu 
    2075                 2080                 2085             


Val Val  Leu Ser Ser Asn Asn  Met Asp Met Phe Ser  Val Ser Val 
    2090                 2095                 2100             


Phe Glu  Asp Phe Ile Tyr Trp  Ser Asp Arg Thr His  Ala Asn Gly 
    2105                 2110                 2115             


Ser Ile  Lys Arg Gly Ser Lys  Asp Asn Ala Thr Asp  Ser Val Pro 
    2120                 2125                 2130             


Leu Arg  Thr Gly Ile Gly Val  Gln Leu Lys Asp Ile  Lys Val Phe 
    2135                 2140                 2145             


Asn Arg  Asp Arg Gln Lys Gly  Thr Asn Val Cys Ala  Val Ala Asn 
    2150                 2155                 2160             


Gly Gly  Cys Gln Gln Leu Cys  Leu Tyr Arg Gly Arg  Gly Gln Arg 
    2165                 2170                 2175             


Ala Cys  Ala Cys Ala His Gly  Met Leu Ala Glu Asp  Gly Ala Ser 
    2180                 2185                 2190             


Cys Arg  Glu Tyr Ala Gly Tyr  Leu Leu Tyr Ser Glu  Arg Thr Ile 
    2195                 2200                 2205             


Leu Lys  Ser Ile His Leu Ser  Asp Glu Arg Asn Leu  Asn Ala Pro 
    2210                 2215                 2220             


Val Gln  Pro Phe Glu Asp Pro  Glu His Met Lys Asn  Val Ile Ala 
    2225                 2230                 2235             


Leu Ala  Phe Asp Tyr Arg Ala  Gly Thr Ser Pro Gly  Thr Pro Asn 
    2240                 2245                 2250             


Arg Ile  Phe Phe Ser Asp Ile  His Phe Gly Asn Ile  Gln Gln Ile 
    2255                 2260                 2265             


Asn Asp  Asp Gly Ser Arg Arg  Ile Thr Ile Val Glu  Asn Val Gly 
    2270                 2275                 2280             


Ser Val  Glu Gly Leu Ala Tyr  His Arg Gly Trp Asp  Thr Leu Tyr 
    2285                 2290                 2295             


Trp Thr  Ser Tyr Thr Thr Ser  Thr Ile Thr Arg His  Thr Val Asp 
    2300                 2305                 2310             


Gln Thr  Arg Pro Gly Ala Phe  Glu Arg Glu Thr Val  Ile Thr Met 
    2315                 2320                 2325             


Ser Gly  Asp Asp His Pro Arg  Ala Phe Val Leu Asp  Glu Cys Gln 
    2330                 2335                 2340             


Asn Leu  Met Phe Trp Thr Asn  Trp Asn Glu Gln His  Pro Ser Ile 
    2345                 2350                 2355             


Met Arg  Ala Ala Leu Ser Gly  Ala Asn Val Leu Thr  Leu Ile Glu 
    2360                 2365                 2370             


Lys Asp  Ile Arg Thr Pro Asn  Gly Leu Ala Ile Asp  His Arg Ala 
    2375                 2380                 2385             


Glu Lys  Leu Tyr Phe Ser Asp  Ala Thr Leu Asp Lys  Ile Glu Arg 
    2390                 2395                 2400             


Cys Glu  Tyr Asp Gly Ser His  Arg Tyr Val Ile Leu  Lys Ser Glu 
    2405                 2410                 2415             


Pro Val  His Pro Phe Gly Leu  Ala Val Tyr Gly Glu  His Ile Phe 
    2420                 2425                 2430             


Trp Thr  Asp Trp Val Arg Arg  Ala Val Gln Arg Ala  Asn Lys His 
    2435                 2440                 2445             


Val Gly  Ser Asn Met Lys Leu  Leu Arg Val Asp Ile  Pro Gln Gln 
    2450                 2455                 2460             


Pro Met  Gly Ile Ile Ala Val  Ala Asn Asp Thr Asn  Ser Cys Glu 
    2465                 2470                 2475             


Leu Ser  Pro Cys Arg Ile Asn  Asn Gly Gly Cys Gln  Asp Leu Cys 
    2480                 2485                 2490             


Leu Leu  Thr His Gln Gly His  Val Asn Cys Ser Cys  Arg Gly Gly 
    2495                 2500                 2505             


Arg Ile  Leu Gln Asp Asp Leu  Thr Cys Arg Ala Val  Asn Ser Ser 
    2510                 2515                 2520             


Cys Arg  Ala Gln Asp Glu Phe  Glu Cys Ala Asn Gly  Glu Cys Ile 
    2525                 2530                 2535             


Asn Phe  Ser Leu Thr Cys Asp  Gly Val Pro His Cys  Lys Asp Lys 
    2540                 2545                 2550             


Ser Asp  Glu Lys Pro Ser Tyr  Cys Asn Ser Arg Arg  Cys Lys Lys 
    2555                 2560                 2565             


Thr Phe  Arg Gln Cys Ser Asn  Gly Arg Cys Val Ser  Asn Met Leu 
    2570                 2575                 2580             


Trp Cys  Asn Gly Ala Asp Asp  Cys Gly Asp Gly Ser  Asp Glu Ile 
    2585                 2590                 2595             


Pro Cys  Asn Lys Thr Ala Cys  Gly Val Gly Glu Phe  Arg Cys Arg 
    2600                 2605                 2610             


Asp Gly  Thr Cys Ile Gly Asn  Ser Ser Arg Cys Asn  Gln Phe Val 
    2615                 2620                 2625             


Asp Cys  Glu Asp Ala Ser Asp  Glu Met Asn Cys Ser  Ala Thr Asp 
    2630                 2635                 2640             


Cys Ser  Ser Tyr Phe Arg Leu  Gly Val Lys Gly Val  Leu Phe Gln 
    2645                 2650                 2655             


Pro Cys  Glu Arg Thr Ser Leu  Cys Tyr Ala Pro Ser  Trp Val Cys 
    2660                 2665                 2670             


Asp Gly  Ala Asn Asp Cys Gly  Asp Tyr Ser Asp Glu  Arg Asp Cys 
    2675                 2680                 2685             


Pro Gly  Val Lys Arg Pro Arg  Cys Pro Leu Asn Tyr  Phe Ala Cys 
    2690                 2695                 2700             


Pro Ser  Gly Arg Cys Ile Pro  Met Ser Trp Thr Cys  Asp Lys Glu 
    2705                 2710                 2715             


Asp Asp  Cys Glu His Gly Glu  Asp Glu Thr His Cys  Asn Lys Phe 
    2720                 2725                 2730             


Cys Ser  Glu Ala Gln Phe Glu  Cys Gln Asn His Arg  Cys Ile Ser 
    2735                 2740                 2745             


Lys Gln  Trp Leu Cys Asp Gly  Ser Asp Asp Cys Gly  Asp Gly Ser 
    2750                 2755                 2760             


Asp Glu  Ala Ala His Cys Glu  Gly Lys Thr Cys Gly  Pro Ser Ser 
    2765                 2770                 2775             


Phe Ser  Cys Pro Gly Thr His  Val Cys Val Pro Glu  Arg Trp Leu 
    2780                 2785                 2790             


Cys Asp  Gly Asp Lys Asp Cys  Ala Asp Gly Ala Asp  Glu Ser Ile 
    2795                 2800                 2805             


Ala Ala  Gly Cys Leu Tyr Asn  Ser Thr Cys Asp Asp  Arg Glu Phe 
    2810                 2815                 2820             


Met Cys  Gln Asn Arg Gln Cys  Ile Pro Lys His Phe  Val Cys Asp 
    2825                 2830                 2835             


His Asp  Arg Asp Cys Ala Asp  Gly Ser Asp Glu Ser  Pro Glu Cys 
    2840                 2845                 2850             


Glu Tyr  Pro Thr Cys Gly Pro  Ser Glu Phe Arg Cys  Ala Asn Gly 
    2855                 2860                 2865             


Arg Cys  Leu Ser Ser Arg Gln  Trp Glu Cys Asp Gly  Glu Asn Asp 
    2870                 2875                 2880             


Cys His  Asp Gln Ser Asp Glu  Ala Pro Lys Asn Pro  His Cys Thr 
    2885                 2890                 2895             


Ser Gln  Glu His Lys Cys Asn  Ala Ser Ser Gln Phe  Leu Cys Ser 
    2900                 2905                 2910             


Ser Gly  Arg Cys Val Ala Glu  Ala Leu Leu Cys Asn  Gly Gln Asp 
    2915                 2920                 2925             


Asp Cys  Gly Asp Ser Ser Asp  Glu Arg Gly Cys His  Ile Asn Glu 
    2930                 2935                 2940             


Cys Leu  Ser Arg Lys Leu Ser  Gly Cys Ser Gln Asp  Cys Glu Asp 
    2945                 2950                 2955             


Leu Lys  Ile Gly Phe Lys Cys  Arg Cys Arg Pro Gly  Phe Arg Leu 
    2960                 2965                 2970             


Lys Asp  Asp Gly Arg Thr Cys  Ala Asp Val Asp Glu  Cys Ser Thr 
    2975                 2980                 2985             


Thr Phe  Pro Cys Ser Gln Arg  Cys Ile Asn Thr His  Gly Ser Tyr 
    2990                 2995                 3000             


Lys Cys  Leu Cys Val Glu Gly  Tyr Ala Pro Arg Gly  Gly Asp Pro 
    3005                 3010                 3015             


His Ser  Cys Lys Ala Val Thr  Asp Glu Glu Pro Phe  Leu Ile Phe 
    3020                 3025                 3030             


Ala Asn  Arg Tyr Tyr Leu Arg  Lys Leu Asn Leu Asp  Gly Ser Asn 
    3035                 3040                 3045             


Tyr Thr  Leu Leu Lys Gln Gly  Leu Asn Asn Ala Val  Ala Leu Asp 
    3050                 3055                 3060             


Phe Asp  Tyr Arg Glu Gln Met  Ile Tyr Trp Thr Asp  Val Thr Thr 
    3065                 3070                 3075             


Gln Gly  Ser Met Ile Arg Arg  Met His Leu Asn Gly  Ser Asn Val 
    3080                 3085                 3090             


Gln Val  Leu His Arg Thr Gly  Leu Ser Asn Pro Asp  Gly Leu Ala 
    3095                 3100                 3105             


Val Asp  Trp Val Gly Gly Asn  Leu Tyr Trp Cys Asp  Lys Gly Arg 
    3110                 3115                 3120             


Asp Thr  Ile Glu Val Ser Lys  Leu Asn Gly Ala Tyr  Arg Thr Val 
    3125                 3130                 3135             


Leu Val  Ser Ser Gly Leu Arg  Glu Pro Arg Ala Leu  Val Val Asp 
    3140                 3145                 3150             


Val Gln  Asn Gly Tyr Leu Tyr  Trp Thr Asp Trp Gly  Asp His Ser 
    3155                 3160                 3165             


Leu Ile  Gly Arg Ile Gly Met  Asp Gly Ser Ser Arg  Ser Val Ile 
    3170                 3175                 3180             


Val Asp  Thr Lys Ile Thr Trp  Pro Asn Gly Leu Thr  Leu Asp Tyr 
    3185                 3190                 3195             


Val Thr  Glu Arg Ile Tyr Trp  Ala Asp Ala Arg Glu  Asp Tyr Ile 
    3200                 3205                 3210             


Glu Phe  Ala Ser Leu Asp Gly  Ser Asn Arg His Val  Val Leu Ser 
    3215                 3220                 3225             


Gln Asp  Ile Pro His Ile Phe  Ala Leu Thr Leu Phe  Glu Asp Tyr 
    3230                 3235                 3240             


Val Tyr  Trp Thr Asp Trp Glu  Thr Lys Ser Ile Asn  Arg Ala His 
    3245                 3250                 3255             


Lys Thr  Thr Gly Thr Asn Lys  Thr Leu Leu Ile Ser  Thr Leu His 
    3260                 3265                 3270             


Arg Pro  Met Asp Leu His Val  Phe His Ala Leu Arg  Gln Pro Asp 
    3275                 3280                 3285             


Val Pro  Asn His Pro Cys Lys  Val Asn Asn Gly Gly  Cys Ser Asn 
    3290                 3295                 3300             


Leu Cys  Leu Leu Ser Pro Gly  Gly Gly His Lys Cys  Ala Cys Pro 
    3305                 3310                 3315             


Thr Asn  Phe Tyr Leu Gly Ser  Asp Gly Arg Thr Cys  Val Ser Asn 
    3320                 3325                 3330             


Cys Thr  Ala Ser Gln Phe Val  Cys Lys Asn Asp Lys  Cys Ile Pro 
    3335                 3340                 3345             


Phe Trp  Trp Lys Cys Asp Thr  Glu Asp Asp Cys Gly  Asp His Ser 
    3350                 3355                 3360             


Asp Glu  Pro Pro Asp Cys Pro  Glu Phe Lys Cys Arg  Pro Gly Gln 
    3365                 3370                 3375             


Phe Gln  Cys Ser Thr Gly Ile  Cys Thr Asn Pro Ala  Phe Ile Cys 
    3380                 3385                 3390             


Asp Gly  Asp Asn Asp Cys Gln  Asp Asn Ser Asp Glu  Ala Asn Cys 
    3395                 3400                 3405             


Asp Ile  His Val Cys Leu Pro  Ser Gln Phe Lys Cys  Thr Asn Thr 
    3410                 3415                 3420             


Asn Arg  Cys Ile Pro Gly Ile  Phe Arg Cys Asn Gly  Gln Asp Asn 
    3425                 3430                 3435             


Cys Gly  Asp Gly Glu Asp Glu  Arg Asp Cys Pro Glu  Val Thr Cys 
    3440                 3445                 3450             


Ala Pro  Asn Gln Phe Gln Cys  Ser Ile Thr Lys Arg  Cys Ile Pro 
    3455                 3460                 3465             


Arg Val  Trp Val Cys Asp Arg  Asp Asn Asp Cys Val  Asp Gly Ser 
    3470                 3475                 3480             


Asp Glu  Pro Ala Asn Cys Thr  Gln Met Thr Cys Gly  Val Asp Glu 
    3485                 3490                 3495             


Phe Arg  Cys Lys Asp Ser Gly  Arg Cys Ile Pro Ala  Arg Trp Lys 
    3500                 3505                 3510             


Cys Asp  Gly Glu Asp Asp Cys  Gly Asp Gly Ser Asp  Glu Pro Lys 
    3515                 3520                 3525             


Glu Glu  Cys Asp Glu Arg Thr  Cys Glu Pro Tyr Gln  Phe Arg Cys 
    3530                 3535                 3540             


Lys Asn  Asn Arg Cys Val Pro  Gly Arg Trp Gln Cys  Asp Tyr Asp 
    3545                 3550                 3555             


Asn Asp  Cys Gly Asp Asn Ser  Asp Glu Glu Ser Cys  Thr Pro Arg 
    3560                 3565                 3570             


Pro Cys  Ser Glu Ser Glu Phe  Ser Cys Ala Asn Gly  Arg Cys Ile 
    3575                 3580                 3585             


Ala Gly  Arg Trp Lys Cys Asp  Gly Asp His Asp Cys  Ala Asp Gly 
    3590                 3595                 3600             


Ser Asp  Glu Lys Asp Cys Thr  Pro Arg Cys Asp Met  Asp Gln Phe 
    3605                 3610                 3615             


Gln Cys  Lys Ser Gly His Cys  Ile Pro Leu Arg Trp  Arg Cys Asp 
    3620                 3625                 3630             


Ala Asp  Ala Asp Cys Met Asp  Gly Ser Asp Glu Glu  Ala Cys Gly 
    3635                 3640                 3645             


Thr Gly  Val Arg Thr Cys Pro  Leu Asp Glu Phe Gln  Cys Asn Asn 
    3650                 3655                 3660             


Thr Leu  Cys Lys Pro Leu Ala  Trp Lys Cys Asp Gly  Glu Asp Asp 
    3665                 3670                 3675             


Cys Gly  Asp Asn Ser Asp Glu  Asn Pro Glu Glu Cys  Ala Arg Phe 
    3680                 3685                 3690             


Val Cys  Pro Pro Asn Arg Pro  Phe Arg Cys Lys Asn  Asp Arg Val 
    3695                 3700                 3705             


Cys Leu  Trp Ile Gly Arg Gln  Cys Asp Gly Thr Asp  Asn Cys Gly 
    3710                 3715                 3720             


Asp Gly  Thr Asp Glu Glu Asp  Cys Glu Pro Pro Thr  Ala His Thr 
    3725                 3730                 3735             


Thr His  Cys Lys Asp Lys Lys  Glu Phe Leu Cys Arg  Asn Gln Arg 
    3740                 3745                 3750             


Cys Leu  Ser Ser Ser Leu Arg  Cys Asn Met Phe Asp  Asp Cys Gly 
    3755                 3760                 3765             


Asp Gly  Ser Asp Glu Glu Asp  Cys Ser Ile Asp Pro  Lys Leu Thr 
    3770                 3775                 3780             


Ser Cys  Ala Thr Asn Ala Ser  Ile Cys Gly Asp Glu  Ala Arg Cys 
    3785                 3790                 3795             


Val Arg  Thr Glu Lys Ala Ala  Tyr Cys Ala Cys Arg  Ser Gly Phe 
    3800                 3805                 3810             


His Thr  Val Pro Gly Gln Pro  Gly Cys Gln Asp Ile  Asn Glu Cys 
    3815                 3820                 3825             


Leu Arg  Phe Gly Thr Cys Ser  Gln Leu Cys Asn Asn  Thr Lys Gly 
    3830                 3835                 3840             


Gly His  Leu Cys Ser Cys Ala  Arg Asn Phe Met Lys  Thr His Asn 
    3845                 3850                 3855             


Thr Cys  Lys Ala Glu Gly Ser  Glu Tyr Gln Val Leu  Tyr Ile Ala 
    3860                 3865                 3870             


Asp Asp  Asn Glu Ile Arg Ser  Leu Phe Pro Gly His  Pro His Ser 
    3875                 3880                 3885             


Ala Tyr  Glu Gln Ala Phe Gln  Gly Asp Glu Ser Val  Arg Ile Asp 
    3890                 3895                 3900             


Ala Met  Asp Val His Val Lys  Ala Gly Arg Val Tyr  Trp Thr Asn 
    3905                 3910                 3915             


Trp His  Thr Gly Thr Ile Ser  Tyr Arg Ser Leu Pro  Pro Ala Ala 
    3920                 3925                 3930             


Pro Pro  Thr Thr Ser Asn Arg  His Arg Arg Gln Ile  Asp Arg Gly 
    3935                 3940                 3945             


Val Thr  His Leu Asn Ile Ser  Gly Leu Lys Met Pro  Arg Gly Ile 
    3950                 3955                 3960             


Ala Ile  Asp Trp Val Ala Gly  Asn Val Tyr Trp Thr  Asp Ser Gly 
    3965                 3970                 3975             


Arg Asp  Val Ile Glu Val Ala  Gln Met Lys Gly Glu  Asn Arg Lys 
    3980                 3985                 3990             


Thr Leu  Ile Ser Gly Met Ile  Asp Glu Pro His Ala  Ile Val Val 
    3995                 4000                 4005             


Asp Pro  Leu Arg Gly Thr Met  Tyr Trp Ser Asp Trp  Gly Asn His 
    4010                 4015                 4020             


Pro Lys  Ile Glu Thr Ala Ala  Met Asp Gly Thr Leu  Arg Glu Thr 
    4025                 4030                 4035             


Leu Val  Gln Asp Asn Ile Gln  Trp Pro Thr Gly Leu  Ala Val Asp 
    4040                 4045                 4050             


Tyr His  Asn Glu Arg Leu Tyr  Trp Ala Asp Ala Lys  Leu Ser Val 
    4055                 4060                 4065             


Ile Gly  Ser Ile Arg Leu Asn  Gly Thr Asp Pro Ile  Val Ala Ala 
    4070                 4075                 4080             


Asp Ser  Lys Arg Gly Leu Ser  His Pro Phe Ser Ile  Asp Val Phe 
    4085                 4090                 4095             


Glu Asp  Tyr Ile Tyr Gly Val  Thr Tyr Ile Asn Asn  Arg Val Phe 
    4100                 4105                 4110             


Lys Ile  His Lys Phe Gly His  Ser Pro Leu Val Asn  Leu Thr Gly 
    4115                 4120                 4125             


Gly Leu  Ser His Ala Ser Asp  Val Val Leu Tyr His  Gln His Lys 
    4130                 4135                 4140             


Gln Pro  Glu Val Thr Asn Pro  Cys Asp Arg Lys Lys  Cys Glu Trp 
    4145                 4150                 4155             


Leu Cys  Leu Leu Ser Pro Ser  Gly Pro Val Cys Thr  Cys Pro Asn 
    4160                 4165                 4170             


Gly Lys  Arg Leu Asp Asn Gly  Thr Cys Val Pro Val  Pro Ser Pro 
    4175                 4180                 4185             


Thr Pro  Pro Pro Asp Ala Pro  Arg Pro Gly Thr Cys  Asn Leu Gln 
    4190                 4195                 4200             


Cys Phe  Asn Gly Gly Ser Cys  Phe Leu Asn Ala Arg  Arg Gln Pro 
    4205                 4210                 4215             


Lys Cys  Arg Cys Gln Pro Arg  Tyr Thr Gly Asp Lys  Cys Glu Leu 
    4220                 4225                 4230             


Asp Gln  Cys Trp Glu His Cys  Arg Asn Gly Gly Thr  Cys Ala Ala 
    4235                 4240                 4245             


Ser Pro  Ser Gly Met Pro Thr  Cys Arg Cys Pro Thr  Gly Phe Thr 
    4250                 4255                 4260             


Gly Pro  Lys Cys Thr Gln Gln  Val Cys Ala Gly Tyr  Cys Ala Asn 
    4265                 4270                 4275             


Asn Ser  Thr Cys Thr Val Asn  Gln Gly Asn Gln Pro  Gln Cys Arg 
    4280                 4285                 4290             


Cys Leu  Pro Gly Phe Leu Gly  Asp Arg Cys Gln Tyr  Arg Gln Cys 
    4295                 4300                 4305             


Ser Gly  Tyr Cys Glu Asn Phe  Gly Thr Cys Gln Met  Ala Ala Asp 
    4310                 4315                 4320             


Gly Ser  Arg Gln Cys Arg Cys  Thr Ala Tyr Phe Glu  Gly Ser Arg 
    4325                 4330                 4335             


Cys Glu  Val Asn Lys Cys Ser  Arg Cys Leu Glu Gly  Ala Cys Val 
    4340                 4345                 4350             


Val Asn  Lys Gln Ser Gly Asp  Val Thr Cys Asn Cys  Thr Asp Gly 
    4355                 4360                 4365             


Arg Val  Ala Pro Ser Cys Leu  Thr Cys Val Gly His  Cys Ser Asn 
    4370                 4375                 4380             


Gly Gly  Ser Cys Thr Met Asn  Ser Lys Met Met Pro  Glu Cys Gln 
    4385                 4390                 4395             


Cys Pro  Pro His Met Thr Gly  Pro Arg Cys Glu Glu  His Val Phe 
    4400                 4405                 4410             


Ser Gln  Gln Gln Pro Gly His  Ile Ala Ser Ile Leu  Ile Pro Leu 
    4415                 4420                 4425             


Leu Leu  Leu Leu Leu Leu Val  Leu Val Ala Gly Val  Val Phe Trp 
    4430                 4435                 4440             


Tyr Lys  Arg Arg Val Gln Gly  Ala Lys Gly Phe Gln  His Gln Arg 
    4445                 4450                 4455             


Met Thr  Asn Gly Ala Met Asn  Val Glu Ile Gly Asn  Pro Thr Tyr 
    4460                 4465                 4470             


Lys Met  Tyr Glu Gly Gly Glu  Pro Asp Asp Val Gly  Gly Leu Leu 
    4475                 4480                 4485             


Asp Ala  Asp Phe Ala Leu Asp  Pro Asp Lys Pro Thr  Asn Phe Thr 
    4490                 4495                 4500             


Asn Pro  Val Tyr Ala Thr Leu  Tyr Met Gly Gly His  Gly Ser Arg 
    4505                 4510                 4515             


His Ser  Leu Ala Ser Thr Asp  Glu Lys Arg Glu Leu  Leu Gly Arg 
    4520                 4525                 4530             


Gly Pro  Glu Asp Glu Ile Gly  Asp Pro Leu Ala 
    4535                 4540                 


<210>  2620
<211>  770
<212>  PRT
<213>  Homo sapiens

<400>  2620

Met Glu Lys Arg Ala Ala Ala Gly Leu Glu Gly Ala Pro Gly Ala Arg 
1               5                   10                  15      


Ala Gln Leu Ala Val Val Cys Leu Val Asn Ile Phe Leu Thr Gly Arg 
            20                  25                  30          


Leu Ser Ser Ala Val Pro Ala Leu Ala Ala Cys Ser Gly Lys Leu Glu 
        35                  40                  45              


Gln His Thr Glu Arg Arg Gly Val Ile Tyr Ser Pro Ala Trp Pro Leu 
    50                  55                  60                  


Asn Tyr Pro Pro Gly Thr Asn Cys Ser Trp Tyr Ile Gln Gly Asp Arg 
65                  70                  75                  80  


Gly Asp Met Ile Thr Ile Ser Phe Arg Asn Phe Asp Val Glu Glu Ser 
                85                  90                  95      


His Gln Cys Ser Leu Asp Trp Leu Leu Leu Gly Pro Ala Ala Pro Pro 
            100                 105                 110         


Arg Gln Glu Ala Phe Arg Leu Cys Gly Ser Ala Ile Pro Pro Ala Phe 
        115                 120                 125             


Ile Ser Ala Arg Asp His Val Trp Ile Phe Phe His Ser Asp Ala Ser 
    130                 135                 140                 


Ser Ser Gly Gln Ala Gln Gly Phe Arg Leu Ser Tyr Ile Arg Gly Lys 
145                 150                 155                 160 


Leu Gly Gln Ala Ser Cys Gln Ala Asp Glu Phe Arg Cys Asp Asn Gly 
                165                 170                 175     


Lys Cys Leu Pro Gly Pro Trp Gln Cys Asn Thr Val Asp Glu Cys Gly 
            180                 185                 190         


Asp Gly Ser Asp Glu Gly Asn Cys Ser Ala Pro Ala Ser Glu Pro Pro 
        195                 200                 205             


Gly Ser Leu Cys Pro Gly Gly Thr Phe Pro Cys Ser Gly Ala Arg Ser 
    210                 215                 220                 


Thr Arg Cys Leu Pro Val Glu Arg Arg Cys Asp Gly Leu Gln Asp Cys 
225                 230                 235                 240 


Gly Asp Gly Ser Asp Glu Ala Gly Cys Pro Asp Leu Ala Cys Gly Arg 
                245                 250                 255     


Arg Leu Gly Ser Phe Tyr Gly Ser Phe Ala Ser Pro Asp Leu Phe Gly 
            260                 265                 270         


Ala Ala Arg Gly Pro Ser Asp Leu His Cys Thr Trp Leu Val Asp Thr 
        275                 280                 285             


Gln Asp Ser Arg Arg Val Leu Leu Gln Leu Glu Leu Arg Leu Gly Tyr 
    290                 295                 300                 


Asp Asp Tyr Val Gln Val Tyr Glu Gly Leu Gly Glu Arg Gly Asp Arg 
305                 310                 315                 320 


Leu Leu Gln Thr Leu Ser Tyr Arg Ser Asn His Arg Pro Val Ser Leu 
                325                 330                 335     


Glu Ala Ala Gln Gly Arg Leu Thr Val Ala Tyr His Ala Arg Ala Arg 
            340                 345                 350         


Ser Ala Gly His Gly Phe Asn Ala Thr Tyr Gln Val Lys Gly Tyr Cys 
        355                 360                 365             


Leu Pro Trp Glu Gln Pro Cys Gly Ser Ser Ser Asp Ser Asp Gly Gly 
    370                 375                 380                 


Ser Leu Gly Asp Gln Gly Cys Phe Ser Glu Pro Gln Arg Cys Asp Gly 
385                 390                 395                 400 


Trp Trp His Cys Ala Ser Gly Arg Asp Glu Gln Gly Cys Pro Ala Cys 
                405                 410                 415     


Pro Pro Asp Gln Tyr Pro Cys Glu Gly Gly Ser Gly Leu Cys Tyr Thr 
            420                 425                 430         


Pro Ala Asp Arg Cys Asn Asn Gln Lys Ser Cys Pro Asp Gly Ala Asp 
        435                 440                 445             


Glu Lys Asn Cys Phe Ser Cys Gln Pro Gly Thr Phe His Cys Gly Thr 
    450                 455                 460                 


Asn Leu Cys Ile Phe Glu Thr Trp Arg Cys Asp Gly Gln Glu Asp Cys 
465                 470                 475                 480 


Gln Asp Gly Ser Asp Glu His Gly Cys Leu Ala Ala Val Pro Arg Lys 
                485                 490                 495     


Val Ile Thr Ala Ala Leu Ile Gly Ser Leu Val Cys Gly Leu Leu Leu 
            500                 505                 510         


Val Ile Ala Leu Gly Cys Ala Phe Lys Leu Tyr Ser Leu Arg Thr Gln 
        515                 520                 525             


Glu Tyr Arg Ala Phe Glu Thr Gln Met Thr Arg Leu Glu Ala Glu Phe 
    530                 535                 540                 


Val Arg Arg Glu Ala Pro Pro Ser Tyr Gly Gln Leu Ile Ala Gln Gly 
545                 550                 555                 560 


Leu Ile Pro Pro Val Glu Asp Phe Pro Val Tyr Ser Ala Ser Gln Ala 
                565                 570                 575     


Ser Val Leu Gln Asn Leu Arg Thr Ala Met Arg Arg Gln Met Arg Arg 
            580                 585                 590         


His Ala Ser Arg Arg Gly Pro Ser Arg Arg Arg Leu Gly Arg Leu Trp 
        595                 600                 605             


Asn Arg Leu Phe His Arg Pro Arg Ala Pro Arg Gly Gln Ile Pro Leu 
    610                 615                 620                 


Leu Thr Ala Ala Arg Pro Ser Gln Thr Val Leu Gly Asp Gly Phe Leu 
625                 630                 635                 640 


Gln Pro Ala Pro Gly Ala Ala Pro Asp Pro Pro Ala Pro Leu Met Asp 
                645                 650                 655     


Thr Gly Ser Thr Arg Ala Ala Gly Asp Arg Pro Pro Ser Ala Pro Gly 
            660                 665                 670         


Arg Ala Pro Glu Val Gly Pro Ser Gly Pro Pro Leu Pro Ser Gly Leu 
        675                 680                 685             


Arg Asp Pro Glu Cys Arg Pro Val Asp Lys Asp Arg Lys Val Cys Arg 
    690                 695                 700                 


Glu Pro Leu Val Asp Gly Pro Ala Pro Ala Asp Ala Pro Arg Glu Pro 
705                 710                 715                 720 


Cys Ser Ala Gln Asp Pro His Pro Gln Val Ser Thr Ala Ser Ser Thr 
                725                 730                 735     


Leu Gly Pro His Ser Pro Glu Pro Leu Gly Val Cys Arg Asn Pro Pro 
            740                 745                 750         


Pro Pro Cys Ser Pro Met Leu Glu Ala Ser Asp Asp Glu Ala Leu Leu 
        755                 760                 765             


Val Cys 
    770 


<210>  2621
<211>  1905
<212>  PRT
<213>  Homo sapiens

<400>  2621

Met Arg Arg Gln Trp Gly Ala Leu Leu Leu Gly Ala Leu Leu Cys Ala 
1               5                   10                  15      


His Gly Leu Ala Ser Ser Pro Glu Cys Ala Cys Gly Arg Ser His Phe 
            20                  25                  30          


Thr Cys Ala Val Ser Ala Leu Gly Glu Cys Thr Cys Ile Pro Ala Gln 
        35                  40                  45              


Trp Gln Cys Asp Gly Asp Asn Asp Cys Gly Asp His Ser Asp Glu Asp 
    50                  55                  60                  


Gly Cys Ile Leu Pro Thr Cys Ser Pro Leu Asp Phe His Cys Asp Asn 
65                  70                  75                  80  


Gly Lys Cys Ile Arg Arg Ser Trp Val Cys Asp Gly Asp Asn Asp Cys 
                85                  90                  95      


Glu Asp Asp Ser Asp Glu Gln Asp Cys Pro Pro Arg Glu Cys Glu Glu 
            100                 105                 110         


Asp Glu Phe Pro Cys Gln Asn Gly Tyr Cys Ile Arg Ser Leu Trp His 
        115                 120                 125             


Cys Asp Gly Asp Asn Asp Cys Gly Asp Asn Ser Asp Glu Gln Cys Asp 
    130                 135                 140                 


Met Arg Lys Cys Ser Asp Lys Glu Phe Arg Cys Ser Asp Gly Ser Cys 
145                 150                 155                 160 


Ile Ala Glu His Trp Tyr Cys Asp Gly Asp Thr Asp Cys Lys Asp Gly 
                165                 170                 175     


Ser Asp Glu Glu Asn Cys Pro Ser Ala Val Pro Ala Pro Pro Cys Asn 
            180                 185                 190         


Leu Glu Glu Phe Gln Cys Ala Tyr Gly Arg Cys Ile Leu Asp Ile Tyr 
        195                 200                 205             


His Cys Asp Gly Asp Asp Asp Cys Gly Asp Trp Ser Asp Glu Ser Asp 
    210                 215                 220                 


Cys Ser Ser His Gln Pro Cys Arg Ser Gly Glu Phe Met Cys Asp Ser 
225                 230                 235                 240 


Gly Leu Cys Ile Asn Ala Gly Trp Arg Cys Asp Gly Asp Ala Asp Cys 
                245                 250                 255     


Asp Asp Gln Ser Asp Glu Arg Asn Cys Thr Thr Ser Met Cys Thr Ala 
            260                 265                 270         


Glu Gln Phe Arg Cys His Ser Gly Arg Cys Val Arg Leu Ser Trp Arg 
        275                 280                 285             


Cys Asp Gly Glu Asp Asp Cys Ala Asp Asn Ser Asp Glu Glu Asn Cys 
    290                 295                 300                 


Glu Asn Thr Gly Ser Pro Gln Cys Ala Leu Asp Gln Phe Leu Cys Trp 
305                 310                 315                 320 


Asn Gly Arg Cys Ile Gly Gln Arg Lys Leu Cys Asn Gly Val Asn Asp 
                325                 330                 335     


Cys Gly Asp Asn Ser Asp Glu Ser Pro Gln Gln Asn Cys Arg Pro Arg 
            340                 345                 350         


Thr Gly Glu Glu Asn Cys Asn Val Asn Asn Gly Gly Cys Ala Gln Lys 
        355                 360                 365             


Cys Gln Met Val Arg Gly Ala Val Gln Cys Thr Cys His Thr Gly Tyr 
    370                 375                 380                 


Arg Leu Thr Glu Asp Gly His Thr Cys Gln Asp Val Asn Glu Cys Ala 
385                 390                 395                 400 


Glu Glu Gly Tyr Cys Ser Gln Gly Cys Thr Asn Ser Glu Gly Ala Phe 
                405                 410                 415     


Gln Cys Trp Cys Glu Thr Gly Tyr Glu Leu Arg Pro Asp Arg Arg Ser 
            420                 425                 430         


Cys Lys Ala Leu Gly Pro Glu Pro Val Leu Leu Phe Ala Asn Arg Ile 
        435                 440                 445             


Asp Ile Arg Gln Val Leu Pro His Arg Ser Glu Tyr Thr Leu Leu Leu 
    450                 455                 460                 


Asn Asn Leu Glu Asn Ala Ile Ala Leu Asp Phe His His Arg Arg Glu 
465                 470                 475                 480 


Leu Val Phe Trp Ser Asp Val Thr Leu Asp Arg Ile Leu Arg Ala Asn 
                485                 490                 495     


Leu Asn Gly Ser Asn Val Glu Glu Val Val Ser Thr Gly Leu Glu Ser 
            500                 505                 510         


Pro Gly Gly Leu Ala Val Asp Trp Val His Asp Lys Leu Tyr Trp Thr 
        515                 520                 525             


Asp Ser Gly Thr Ser Arg Ile Glu Val Ala Asn Leu Asp Gly Ala His 
    530                 535                 540                 


Arg Lys Val Leu Leu Trp Gln Asn Leu Glu Lys Pro Arg Ala Ile Ala 
545                 550                 555                 560 


Leu His Pro Met Glu Gly Thr Ile Tyr Trp Thr Asp Trp Gly Asn Thr 
                565                 570                 575     


Pro Arg Ile Glu Ala Ser Ser Met Asp Gly Ser Gly Arg Arg Ile Ile 
            580                 585                 590         


Ala Asp Thr His Leu Phe Trp Pro Asn Gly Leu Thr Ile Asp Tyr Ala 
        595                 600                 605             


Gly Arg Arg Met Tyr Trp Val Asp Ala Lys His His Val Ile Glu Arg 
    610                 615                 620                 


Ala Asn Leu Asp Gly Ser His Arg Lys Ala Val Ile Ser Gln Gly Leu 
625                 630                 635                 640 


Pro His Pro Phe Ala Ile Thr Val Phe Glu Asp Ser Leu Tyr Trp Thr 
                645                 650                 655     


Asp Trp His Thr Lys Ser Ile Asn Ser Ala Asn Lys Phe Thr Gly Lys 
            660                 665                 670         


Asn Gln Glu Ile Ile Arg Asn Lys Leu His Phe Pro Met Asp Ile His 
        675                 680                 685             


Thr Leu His Pro Gln Arg Gln Pro Ala Gly Lys Asn Arg Cys Gly Asp 
    690                 695                 700                 


Asn Asn Gly Gly Cys Thr His Leu Cys Leu Pro Ser Gly Gln Asn Tyr 
705                 710                 715                 720 


Thr Cys Ala Cys Pro Thr Gly Phe Arg Lys Ile Ser Ser His Ala Cys 
                725                 730                 735     


Ala Gln Ser Leu Asp Lys Phe Leu Leu Phe Ala Arg Arg Met Asp Ile 
            740                 745                 750         


Arg Arg Ile Ser Phe Asp Thr Glu Asp Leu Ser Asp Asp Val Ile Pro 
        755                 760                 765             


Leu Ala Asp Val Arg Ser Ala Val Ala Leu Asp Trp Asp Ser Arg Asp 
    770                 775                 780                 


Asp His Val Tyr Trp Thr Asp Val Ser Thr Asp Thr Ile Ser Arg Ala 
785                 790                 795                 800 


Lys Trp Asp Gly Thr Gly Gln Glu Val Val Val Asp Thr Ser Leu Glu 
                805                 810                 815     


Ser Pro Ala Gly Leu Ala Ile Asp Trp Val Thr Asn Lys Leu Tyr Trp 
            820                 825                 830         


Thr Asp Ala Gly Thr Asp Arg Ile Glu Val Ala Asn Thr Asp Gly Ser 
        835                 840                 845             


Met Arg Thr Val Leu Ile Trp Glu Asn Leu Asp Arg Pro Arg Asp Ile 
    850                 855                 860                 


Val Val Glu Pro Met Gly Gly Tyr Met Tyr Trp Thr Asp Trp Gly Ala 
865                 870                 875                 880 


Ser Pro Lys Ile Glu Arg Ala Gly Met Asp Ala Ser Gly Arg Gln Val 
                885                 890                 895     


Ile Ile Ser Ser Asn Leu Thr Trp Pro Asn Gly Leu Ala Ile Asp Tyr 
            900                 905                 910         


Gly Ser Gln Arg Leu Tyr Trp Ala Asp Ala Gly Met Lys Thr Ile Glu 
        915                 920                 925             


Phe Ala Gly Leu Asp Gly Ser Lys Arg Lys Val Leu Ile Gly Ser Gln 
    930                 935                 940                 


Leu Pro His Pro Phe Gly Leu Thr Leu Tyr Gly Glu Arg Ile Tyr Trp 
945                 950                 955                 960 


Thr Asp Trp Gln Thr Lys Ser Ile Gln Ser Ala Asp Arg Leu Thr Gly 
                965                 970                 975     


Leu Asp Arg Glu Thr Leu Gln Glu Asn Leu Glu Asn Leu Met Asp Ile 
            980                 985                 990         


His Val Phe His Arg Arg Arg Pro  Pro Val Ser Thr Pro  Cys Ala Met 
        995                 1000                 1005             


Glu Asn  Gly Gly Cys Ser His  Leu Cys Leu Arg Ser  Pro Asn Pro 
    1010                 1015                 1020             


Ser Gly  Phe Ser Cys Thr Cys  Pro Thr Gly Ile Asn  Leu Leu Ser 
    1025                 1030                 1035             


Asp Gly  Lys Thr Cys Ser Pro  Gly Met Asn Ser Phe  Leu Ile Phe 
    1040                 1045                 1050             


Ala Arg  Arg Ile Asp Ile Arg  Met Val Ser Leu Asp  Ile Pro Tyr 
    1055                 1060                 1065             


Phe Ala  Asp Val Val Val Pro  Ile Asn Ile Thr Met  Lys Asn Thr 
    1070                 1075                 1080             


Ile Ala  Ile Gly Val Asp Pro  Gln Glu Gly Lys Val  Tyr Trp Ser 
    1085                 1090                 1095             


Asp Ser  Thr Leu His Arg Ile  Ser Arg Ala Asn Leu  Asp Gly Ser 
    1100                 1105                 1110             


Gln His  Glu Asp Ile Ile Thr  Thr Gly Leu Gln Thr  Thr Asp Gly 
    1115                 1120                 1125             


Leu Ala  Val Asp Ala Ile Gly  Arg Lys Val Tyr Trp  Thr Asp Thr 
    1130                 1135                 1140             


Gly Thr  Asn Arg Ile Glu Val  Gly Asn Leu Asp Gly  Ser Met Arg 
    1145                 1150                 1155             


Lys Val  Leu Val Trp Gln Asn  Leu Asp Ser Pro Arg  Ala Ile Val 
    1160                 1165                 1170             


Leu Tyr  His Glu Met Gly Phe  Met Tyr Trp Thr Asp  Trp Gly Glu 
    1175                 1180                 1185             


Asn Ala  Lys Leu Glu Arg Ser  Gly Met Asp Gly Ser  Asp Arg Ala 
    1190                 1195                 1200             


Val Leu  Ile Asn Asn Asn Leu  Gly Trp Pro Asn Gly  Leu Thr Val 
    1205                 1210                 1215             


Asp Lys  Ala Ser Ser Gln Leu  Leu Trp Ala Asp Ala  His Thr Glu 
    1220                 1225                 1230             


Arg Ile  Glu Ala Ala Asp Leu  Asn Gly Ala Asn Arg  His Thr Leu 
    1235                 1240                 1245             


Val Ser  Pro Val Gln His Pro  Tyr Gly Leu Thr Leu  Leu Asp Ser 
    1250                 1255                 1260             


Tyr Ile  Tyr Trp Thr Asp Trp  Gln Thr Arg Ser Ile  His Arg Ala 
    1265                 1270                 1275             


Asp Lys  Gly Thr Gly Ser Asn  Val Ile Leu Val Arg  Ser Asn Leu 
    1280                 1285                 1290             


Pro Gly  Leu Met Asp Met Gln  Ala Val Asp Arg Ala  Gln Pro Leu 
    1295                 1300                 1305             


Gly Phe  Asn Lys Cys Gly Ser  Arg Asn Gly Gly Cys  Ser His Leu 
    1310                 1315                 1320             


Cys Leu  Pro Arg Pro Ser Gly  Phe Ser Cys Ala Cys  Pro Thr Gly 
    1325                 1330                 1335             


Ile Gln  Leu Lys Gly Asp Gly  Lys Thr Cys Asp Pro  Ser Pro Glu 
    1340                 1345                 1350             


Thr Tyr  Leu Leu Phe Ser Ser  Arg Gly Ser Ile Arg  Arg Ile Ser 
    1355                 1360                 1365             


Leu Asp  Thr Ser Asp His Thr  Asp Val His Val Pro  Val Pro Glu 
    1370                 1375                 1380             


Leu Asn  Asn Val Ile Ser Leu  Asp Tyr Asp Ser Val  Asp Gly Lys 
    1385                 1390                 1395             


Val Tyr  Tyr Thr Asp Val Phe  Leu Asp Val Ile Arg  Arg Ala Asp 
    1400                 1405                 1410             


Leu Asn  Gly Ser Asn Met Glu  Thr Val Ile Gly Arg  Gly Leu Lys 
    1415                 1420                 1425             


Thr Thr  Asp Gly Leu Ala Val  Asp Trp Val Ala Arg  Asn Leu Tyr 
    1430                 1435                 1440             


Trp Thr  Asp Thr Gly Arg Asn  Thr Ile Glu Ala Ser  Arg Leu Asp 
    1445                 1450                 1455             


Gly Ser  Cys Arg Lys Val Leu  Ile Asn Asn Ser Leu  Asp Glu Pro 
    1460                 1465                 1470             


Arg Ala  Ile Ala Val Phe Pro  Arg Lys Gly Tyr Leu  Phe Trp Thr 
    1475                 1480                 1485             


Asp Trp  Gly His Ile Ala Lys  Ile Glu Arg Ala Asn  Leu Asp Gly 
    1490                 1495                 1500             


Ser Glu  Arg Lys Val Leu Ile  Asn Thr Asp Leu Gly  Trp Pro Asn 
    1505                 1510                 1515             


Gly Leu  Thr Leu Asp Tyr Asp  Thr Arg Arg Ile Tyr  Trp Val Asp 
    1520                 1525                 1530             


Ala His  Leu Asp Arg Ile Glu  Ser Ala Asp Leu Asn  Gly Lys Leu 
    1535                 1540                 1545             


Arg Gln  Val Leu Val Ser His  Val Ser His Pro Phe  Ala Leu Thr 
    1550                 1555                 1560             


Gln Gln  Asp Arg Trp Ile Tyr  Trp Thr Asp Trp Gln  Thr Lys Ser 
    1565                 1570                 1575             


Ile Gln  Arg Val Asp Lys Tyr  Ser Gly Arg Asn Lys  Glu Thr Val 
    1580                 1585                 1590             


Leu Ala  Asn Val Glu Gly Leu  Met Asp Ile Ile Val  Val Ser Pro 
    1595                 1600                 1605             


Gln Arg  Gln Thr Gly Thr Asn  Ala Cys Gly Val Asn  Asn Gly Gly 
    1610                 1615                 1620             


Cys Thr  His Leu Cys Phe Ala  Arg Ala Ser Asp Phe  Val Cys Ala 
    1625                 1630                 1635             


Cys Pro  Asp Glu Pro Asp Ser  Arg Pro Cys Ser Leu  Val Pro Gly 
    1640                 1645                 1650             


Leu Val  Pro Pro Ala Pro Arg  Ala Thr Gly Met Ser  Glu Lys Ser 
    1655                 1660                 1665             


Pro Val  Leu Pro Asn Thr Pro  Pro Thr Thr Leu Tyr  Ser Ser Thr 
    1670                 1675                 1680             


Thr Arg  Thr Arg Thr Ser Leu  Glu Glu Val Glu Gly  Arg Cys Ser 
    1685                 1690                 1695             


Glu Arg  Asp Ala Arg Leu Gly  Leu Cys Ala Arg Ser  Asn Asp Ala 
    1700                 1705                 1710             


Val Pro  Ala Ala Pro Gly Glu  Gly Leu His Ile Ser  Tyr Ala Ile 
    1715                 1720                 1725             


Gly Gly  Leu Leu Ser Ile Leu  Leu Ile Leu Val Val  Ile Ala Ala 
    1730                 1735                 1740             


Leu Met  Leu Tyr Arg His Lys  Lys Ser Lys Phe Thr  Asp Pro Gly 
    1745                 1750                 1755             


Met Gly  Asn Leu Thr Tyr Ser  Asn Pro Ser Tyr Arg  Thr Ser Thr 
    1760                 1765                 1770             


Gln Glu  Val Lys Ile Glu Ala  Ile Pro Lys Pro Ala  Met Tyr Asn 
    1775                 1780                 1785             


Gln Leu  Cys Tyr Lys Lys Glu  Gly Gly Pro Asp His  Asn Tyr Thr 
    1790                 1795                 1800             


Lys Glu  Lys Ile Lys Ile Val  Glu Gly Ile Cys Leu  Leu Ser Gly 
    1805                 1810                 1815             


Asp Asp  Ala Glu Trp Asp Asp  Leu Lys Gln Leu Arg  Ser Ser Arg 
    1820                 1825                 1830             


Gly Gly  Leu Leu Arg Asp His  Val Cys Met Lys Thr  Asp Thr Val 
    1835                 1840                 1845             


Ser Ile  Gln Ala Ser Ser Gly  Ser Leu Asp Asp Thr  Glu Thr Glu 
    1850                 1855                 1860             


Gln Leu  Leu Gln Glu Glu Gln  Ser Glu Cys Ser Ser  Val His Thr 
    1865                 1870                 1875             


Ala Ala  Thr Pro Glu Arg Arg  Gly Ser Leu Pro Asp  Thr Gly Trp 
    1880                 1885                 1890             


Lys His  Glu Arg Lys Leu Ser  Ser Glu Ser Gln Val  
    1895                 1900                 1905 


<210>  2622
<211>  1615
<212>  PRT
<213>  Homo sapiens

<400>  2622

Met Glu Ala Ala Pro Pro Gly Pro Pro Trp Pro Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ala Leu Cys Gly Cys Pro Ala Pro Ala Ala Ala Ser 
            20                  25                  30          


Pro Leu Leu Leu Phe Ala Asn Arg Arg Asp Val Arg Leu Val Asp Ala 
        35                  40                  45              


Gly Gly Val Lys Leu Glu Ser Thr Ile Val Val Ser Gly Leu Glu Asp 
    50                  55                  60                  


Ala Ala Ala Val Asp Phe Gln Phe Ser Lys Gly Ala Val Tyr Trp Thr 
65                  70                  75                  80  


Asp Val Ser Glu Glu Ala Ile Lys Gln Thr Tyr Leu Asn Gln Thr Gly 
                85                  90                  95      


Ala Ala Val Gln Asn Val Val Ile Ser Gly Leu Val Ser Pro Asp Gly 
            100                 105                 110         


Leu Ala Cys Asp Trp Val Gly Lys Lys Leu Tyr Trp Thr Asp Ser Glu 
        115                 120                 125             


Thr Asn Arg Ile Glu Val Ala Asn Leu Asn Gly Thr Ser Arg Lys Val 
    130                 135                 140                 


Leu Phe Trp Gln Asp Leu Asp Gln Pro Arg Ala Ile Ala Leu Asp Pro 
145                 150                 155                 160 


Ala His Gly Tyr Met Tyr Trp Thr Asp Trp Gly Glu Thr Pro Arg Ile 
                165                 170                 175     


Glu Arg Ala Gly Met Asp Gly Ser Thr Arg Lys Ile Ile Val Asp Ser 
            180                 185                 190         


Asp Ile Tyr Trp Pro Asn Gly Leu Thr Ile Asp Leu Glu Glu Gln Lys 
        195                 200                 205             


Leu Tyr Trp Ala Asp Ala Lys Leu Ser Phe Ile His Arg Ala Asn Leu 
    210                 215                 220                 


Asp Gly Ser Phe Arg Gln Lys Val Val Glu Gly Ser Leu Thr His Pro 
225                 230                 235                 240 


Phe Ala Leu Thr Leu Ser Gly Asp Thr Leu Tyr Trp Thr Asp Trp Gln 
                245                 250                 255     


Thr Arg Ser Ile His Ala Cys Asn Lys Arg Thr Gly Gly Lys Arg Lys 
            260                 265                 270         


Glu Ile Leu Ser Ala Leu Tyr Ser Pro Met Asp Ile Gln Val Leu Ser 
        275                 280                 285             


Gln Glu Arg Gln Pro Phe Phe His Thr Arg Cys Glu Glu Asp Asn Gly 
    290                 295                 300                 


Gly Cys Ser His Leu Cys Leu Leu Ser Pro Ser Glu Pro Phe Tyr Thr 
305                 310                 315                 320 


Cys Ala Cys Pro Thr Gly Val Gln Leu Gln Asp Asn Gly Arg Thr Cys 
                325                 330                 335     


Lys Ala Gly Ala Glu Glu Val Leu Leu Leu Ala Arg Arg Thr Asp Leu 
            340                 345                 350         


Arg Arg Ile Ser Leu Asp Thr Pro Asp Phe Thr Asp Ile Val Leu Gln 
        355                 360                 365             


Val Asp Asp Ile Arg His Ala Ile Ala Ile Asp Tyr Asp Pro Leu Glu 
    370                 375                 380                 


Gly Tyr Val Tyr Trp Thr Asp Asp Glu Val Arg Ala Ile Arg Arg Ala 
385                 390                 395                 400 


Tyr Leu Asp Gly Ser Gly Ala Gln Thr Leu Val Asn Thr Glu Ile Asn 
                405                 410                 415     


Asp Pro Asp Gly Ile Ala Val Asp Trp Val Ala Arg Asn Leu Tyr Trp 
            420                 425                 430         


Thr Asp Thr Gly Thr Asp Arg Ile Glu Val Thr Arg Leu Asn Gly Thr 
        435                 440                 445             


Ser Arg Lys Ile Leu Val Ser Glu Asp Leu Asp Glu Pro Arg Ala Ile 
    450                 455                 460                 


Ala Leu His Pro Val Met Gly Leu Met Tyr Trp Thr Asp Trp Gly Glu 
465                 470                 475                 480 


Asn Pro Lys Ile Glu Cys Ala Asn Leu Asp Gly Gln Glu Arg Arg Val 
                485                 490                 495     


Leu Val Asn Ala Ser Leu Gly Trp Pro Asn Gly Leu Ala Leu Asp Leu 
            500                 505                 510         


Gln Glu Gly Lys Leu Tyr Trp Gly Asp Ala Lys Thr Asp Lys Ile Glu 
        515                 520                 525             


Val Ile Asn Val Asp Gly Thr Lys Arg Arg Thr Leu Leu Glu Asp Lys 
    530                 535                 540                 


Leu Pro His Ile Phe Gly Phe Thr Leu Leu Gly Asp Phe Ile Tyr Trp 
545                 550                 555                 560 


Thr Asp Trp Gln Arg Arg Ser Ile Glu Arg Val His Lys Val Lys Ala 
                565                 570                 575     


Ser Arg Asp Val Ile Ile Asp Gln Leu Pro Asp Leu Met Gly Leu Lys 
            580                 585                 590         


Ala Val Asn Val Ala Lys Val Val Gly Thr Asn Pro Cys Ala Asp Arg 
        595                 600                 605             


Asn Gly Gly Cys Ser His Leu Cys Phe Phe Thr Pro His Ala Thr Arg 
    610                 615                 620                 


Cys Gly Cys Pro Ile Gly Leu Glu Leu Leu Ser Asp Met Lys Thr Cys 
625                 630                 635                 640 


Ile Val Pro Glu Ala Phe Leu Val Phe Thr Ser Arg Ala Ala Ile His 
                645                 650                 655     


Arg Ile Ser Leu Glu Thr Asn Asn Asn Asp Val Ala Ile Pro Leu Thr 
            660                 665                 670         


Gly Val Lys Glu Ala Ser Ala Leu Asp Phe Asp Val Ser Asn Asn His 
        675                 680                 685             


Ile Tyr Trp Thr Asp Val Ser Leu Lys Thr Ile Ser Arg Ala Phe Met 
    690                 695                 700                 


Asn Gly Ser Ser Val Glu His Val Val Glu Phe Gly Leu Asp Tyr Pro 
705                 710                 715                 720 


Glu Gly Met Ala Val Asp Trp Met Gly Lys Asn Leu Tyr Trp Ala Asp 
                725                 730                 735     


Thr Gly Thr Asn Arg Ile Glu Val Ala Arg Leu Asp Gly Gln Phe Arg 
            740                 745                 750         


Gln Val Leu Val Trp Arg Asp Leu Asp Asn Pro Arg Ser Leu Ala Leu 
        755                 760                 765             


Asp Pro Thr Lys Gly Tyr Ile Tyr Trp Thr Glu Trp Gly Gly Lys Pro 
    770                 775                 780                 


Arg Ile Val Arg Ala Phe Met Asp Gly Thr Asn Cys Met Thr Leu Val 
785                 790                 795                 800 


Asp Lys Val Gly Arg Ala Asn Asp Leu Thr Ile Asp Tyr Ala Asp Gln 
                805                 810                 815     


Arg Leu Tyr Trp Thr Asp Leu Asp Thr Asn Met Ile Glu Ser Ser Asn 
            820                 825                 830         


Met Leu Gly Gln Glu Arg Val Val Ile Ala Asp Asp Leu Pro His Pro 
        835                 840                 845             


Phe Gly Leu Thr Gln Tyr Ser Asp Tyr Ile Tyr Trp Thr Asp Trp Asn 
    850                 855                 860                 


Leu His Ser Ile Glu Arg Ala Asp Lys Thr Ser Gly Arg Asn Arg Thr 
865                 870                 875                 880 


Leu Ile Gln Gly His Leu Asp Phe Val Met Asp Ile Leu Val Phe His 
                885                 890                 895     


Ser Ser Arg Gln Asp Gly Leu Asn Asp Cys Met His Asn Asn Gly Gln 
            900                 905                 910         


Cys Gly Gln Leu Cys Leu Ala Ile Pro Gly Gly His Arg Cys Gly Cys 
        915                 920                 925             


Ala Ser His Tyr Thr Leu Asp Pro Ser Ser Arg Asn Cys Ser Pro Pro 
    930                 935                 940                 


Thr Thr Phe Leu Leu Phe Ser Gln Lys Ser Ala Ile Ser Arg Met Ile 
945                 950                 955                 960 


Pro Asp Asp Gln His Ser Pro Asp Leu Ile Leu Pro Leu His Gly Leu 
                965                 970                 975     


Arg Asn Val Lys Ala Ile Asp Tyr Asp Pro Leu Asp Lys Phe Ile Tyr 
            980                 985                 990         


Trp Val Asp Gly Arg Gln Asn Ile  Lys Arg Ala Lys Asp  Asp Gly Thr 
        995                 1000                 1005             


Gln Pro  Phe Val Leu Thr Ser  Leu Ser Gln Gly Gln  Asn Pro Asp 
    1010                 1015                 1020             


Arg Gln  Pro His Asp Leu Ser  Ile Asp Ile Tyr Ser  Arg Thr Leu 
    1025                 1030                 1035             


Phe Trp  Thr Cys Glu Ala Thr  Asn Thr Ile Asn Val  His Arg Leu 
    1040                 1045                 1050             


Ser Gly  Glu Ala Met Gly Val  Val Leu Arg Gly Asp  Arg Asp Lys 
    1055                 1060                 1065             


Pro Arg  Ala Ile Val Val Asn  Ala Glu Arg Gly Tyr  Leu Tyr Phe 
    1070                 1075                 1080             


Thr Asn  Met Gln Asp Arg Ala  Ala Lys Ile Glu Arg  Ala Ala Leu 
    1085                 1090                 1095             


Asp Gly  Thr Glu Arg Glu Val  Leu Phe Thr Thr Gly  Leu Ile Arg 
    1100                 1105                 1110             


Pro Val  Ala Leu Val Val Asp  Asn Thr Leu Gly Lys  Leu Phe Trp 
    1115                 1120                 1125             


Val Asp  Ala Asp Leu Lys Arg  Ile Glu Ser Cys Asp  Leu Ser Gly 
    1130                 1135                 1140             


Ala Asn  Arg Leu Thr Leu Glu  Asp Ala Asn Ile Val  Gln Pro Leu 
    1145                 1150                 1155             


Gly Leu  Thr Ile Leu Gly Lys  His Leu Tyr Trp Ile  Asp Arg Gln 
    1160                 1165                 1170             


Gln Gln  Met Ile Glu Arg Val  Glu Lys Thr Thr Gly  Asp Lys Arg 
    1175                 1180                 1185             


Thr Arg  Ile Gln Gly Arg Val  Ala His Leu Thr Gly  Ile His Ala 
    1190                 1195                 1200             


Val Glu  Glu Val Ser Leu Glu  Glu Phe Ser Ala His  Pro Cys Ala 
    1205                 1210                 1215             


Arg Asp  Asn Gly Gly Cys Ser  His Ile Cys Ile Ala  Lys Gly Asp 
    1220                 1225                 1230             


Gly Thr  Pro Arg Cys Ser Cys  Pro Val His Leu Val  Leu Leu Gln 
    1235                 1240                 1245             


Asn Leu  Leu Thr Cys Gly Glu  Pro Pro Thr Cys Ser  Pro Asp Gln 
    1250                 1255                 1260             


Phe Ala  Cys Ala Thr Gly Glu  Ile Asp Cys Ile Pro  Gly Ala Trp 
    1265                 1270                 1275             


Arg Cys  Asp Gly Phe Pro Glu  Cys Asp Asp Gln Ser  Asp Glu Glu 
    1280                 1285                 1290             


Gly Cys  Pro Val Cys Ser Ala  Ala Gln Phe Pro Cys  Ala Arg Gly 
    1295                 1300                 1305             


Gln Cys  Val Asp Leu Arg Leu  Arg Cys Asp Gly Glu  Ala Asp Cys 
    1310                 1315                 1320             


Gln Asp  Arg Ser Asp Glu Ala  Asp Cys Asp Ala Ile  Cys Leu Pro 
    1325                 1330                 1335             


Asn Gln  Phe Arg Cys Ala Ser  Gly Gln Cys Val Leu  Ile Lys Gln 
    1340                 1345                 1350             


Gln Cys  Asp Ser Phe Pro Asp  Cys Ile Asp Gly Ser  Asp Glu Leu 
    1355                 1360                 1365             


Met Cys  Glu Ile Thr Lys Pro  Pro Ser Asp Asp Ser  Pro Ala His 
    1370                 1375                 1380             


Ser Ser  Ala Ile Gly Pro Val  Ile Gly Ile Ile Leu  Ser Leu Phe 
    1385                 1390                 1395             


Val Met  Gly Gly Val Tyr Phe  Val Cys Gln Arg Val  Val Cys Gln 
    1400                 1405                 1410             


Arg Tyr  Ala Gly Ala Asn Gly  Pro Phe Pro His Glu  Tyr Val Ser 
    1415                 1420                 1425             


Gly Thr  Pro His Val Pro Leu  Asn Phe Ile Ala Pro  Gly Gly Ser 
    1430                 1435                 1440             


Gln His  Gly Pro Phe Thr Gly  Ile Ala Cys Gly Lys  Ser Met Met 
    1445                 1450                 1455             


Ser Ser  Val Ser Leu Met Gly  Gly Arg Gly Gly Val  Pro Leu Tyr 
    1460                 1465                 1470             


Asp Arg  Asn His Val Thr Gly  Ala Ser Ser Ser Ser  Ser Ser Ser 
    1475                 1480                 1485             


Thr Lys  Ala Thr Leu Tyr Pro  Pro Ile Leu Asn Pro  Pro Pro Ser 
    1490                 1495                 1500             


Pro Ala  Thr Asp Pro Ser Leu  Tyr Asn Met Asp Met  Phe Tyr Ser 
    1505                 1510                 1515             


Ser Asn  Ile Pro Ala Thr Ala  Arg Pro Tyr Arg Pro  Tyr Ile Ile 
    1520                 1525                 1530             


Arg Gly  Met Ala Pro Pro Thr  Thr Pro Cys Ser Thr  Asp Val Cys 
    1535                 1540                 1545             


Asp Ser  Asp Tyr Ser Ala Ser  Arg Trp Lys Ala Ser  Lys Tyr Tyr 
    1550                 1555                 1560             


Leu Asp  Leu Asn Ser Asp Ser  Asp Pro Tyr Pro Pro  Pro Pro Thr 
    1565                 1570                 1575             


Pro His  Ser Gln Tyr Leu Ser  Ala Glu Asp Ser Cys  Pro Pro Ser 
    1580                 1585                 1590             


Pro Ala  Thr Glu Arg Ser Tyr  Phe His Leu Phe Pro  Pro Pro Pro 
    1595                 1600                 1605             


Ser Pro  Cys Thr Asp Ser Ser  
    1610                 1615 


<210>  2623
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  2623

Met Ala Pro Arg Arg Val Arg Ser Phe Leu Arg Gly Leu Pro Ala Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Phe Leu Gly Pro Trp Pro Ala Ala Ser His Gly 
            20                  25                  30          


Gly Lys Tyr Ser Arg Glu Lys Asn Gln Pro Lys Pro Ser Pro Lys Arg 
        35                  40                  45              


Glu Ser Gly Glu Glu Phe Arg Met Glu Lys Leu Asn Gln Leu Trp Glu 
    50                  55                  60                  


Lys Ala Gln Arg Leu His Leu Pro Pro Val Arg Leu Ala Glu Leu His 
65                  70                  75                  80  


Ala Asp Leu Lys Ile Gln Glu Arg Asp Glu Leu Ala Trp Lys Lys Leu 
                85                  90                  95      


Lys Leu Asp Gly Leu Asp Glu Asp Gly Glu Lys Glu Ala Arg Leu Ile 
            100                 105                 110         


Arg Asn Leu Asn Val Ile Leu Ala Lys Tyr Gly Leu Asp Gly Lys Lys 
        115                 120                 125             


Asp Ala Arg Gln Val Thr Ser Asn Ser Leu Ser Gly Thr Gln Glu Asp 
    130                 135                 140                 


Gly Leu Asp Asp Pro Arg Leu Glu Lys Leu Trp His Lys Ala Lys Thr 
145                 150                 155                 160 


Ser Gly Lys Phe Ser Gly Glu Glu Leu Asp Lys Leu Trp Arg Glu Phe 
                165                 170                 175     


Leu His His Lys Glu Lys Val His Glu Tyr Asn Val Leu Leu Glu Thr 
            180                 185                 190         


Leu Ser Arg Thr Glu Glu Ile His Glu Asn Val Ile Ser Pro Ser Asp 
        195                 200                 205             


Leu Ser Asp Ile Lys Gly Ser Val Leu His Ser Arg His Thr Glu Leu 
    210                 215                 220                 


Lys Glu Lys Leu Arg Ser Ile Asn Gln Gly Leu Asp Arg Leu Arg Arg 
225                 230                 235                 240 


Val Ser His Gln Gly Tyr Ser Thr Glu Ala Glu Phe Glu Glu Pro Arg 
                245                 250                 255     


Val Ile Asp Leu Trp Asp Leu Ala Gln Ser Ala Asn Leu Thr Asp Lys 
            260                 265                 270         


Glu Leu Glu Ala Phe Arg Glu Glu Leu Lys His Phe Glu Ala Lys Ile 
        275                 280                 285             


Glu Lys His Asn His Tyr Gln Lys Gln Leu Glu Ile Ala His Glu Lys 
    290                 295                 300                 


Leu Arg His Ala Glu Ser Val Gly Asp Gly Glu Arg Val Ser Arg Ser 
305                 310                 315                 320 


Arg Glu Lys His Ala Leu Leu Glu Gly Arg Thr Lys Glu Leu Gly Tyr 
                325                 330                 335     


Thr Val Lys Lys His Leu Gln Asp Leu Ser Gly Arg Ile Ser Arg Ala 
            340                 345                 350         


Arg His Asn Glu Leu 
        355         


<210>  2624
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  2624

Met Val Arg Arg Val Gln Pro Asp Arg Lys Gln Leu Pro Leu Val Leu 
1               5                   10                  15      


Leu Arg Leu Leu Cys Leu Leu Pro Thr Gly Leu Pro Val Arg Ser Val 
            20                  25                  30          


Asp Phe Asn Arg Gly Thr Asp Asn Ile Thr Val Arg Gln Gly Asp Thr 
        35                  40                  45              


Ala Ile Leu Arg Cys Val Val Glu Asp Lys Asn Ser Lys Val Ala Trp 
    50                  55                  60                  


Leu Asn Arg Ser Gly Ile Ile Phe Ala Gly His Asp Lys Trp Ser Leu 
65                  70                  75                  80  


Asp Pro Arg Val Glu Leu Glu Lys Arg His Ser Leu Glu Tyr Ser Leu 
                85                  90                  95      


Arg Ile Gln Lys Val Asp Val Tyr Asp Glu Gly Ser Tyr Thr Cys Ser 
            100                 105                 110         


Val Gln Thr Gln His Glu Pro Lys Thr Ser Gln Val Tyr Leu Ile Val 
        115                 120                 125             


Gln Val Pro Pro Lys Ile Ser Asn Ile Ser Ser Asp Val Thr Val Asn 
    130                 135                 140                 


Glu Gly Ser Asn Val Thr Leu Val Cys Met Ala Asn Gly Arg Pro Glu 
145                 150                 155                 160 


Pro Val Ile Thr Trp Arg His Leu Thr Pro Thr Gly Arg Glu Phe Glu 
                165                 170                 175     


Gly Glu Glu Glu Tyr Leu Glu Ile Leu Gly Ile Thr Arg Glu Gln Ser 
            180                 185                 190         


Gly Lys Tyr Glu Cys Lys Ala Ala Asn Glu Val Ser Ser Ala Asp Val 
        195                 200                 205             


Lys Gln Val Lys Val Thr Val Asn Tyr Pro Pro Thr Ile Thr Glu Ser 
    210                 215                 220                 


Lys Ser Asn Glu Ala Thr Thr Gly Arg Gln Ala Ser Leu Lys Cys Glu 
225                 230                 235                 240 


Ala Ser Ala Val Pro Ala Pro Asp Phe Glu Trp Tyr Arg Asp Asp Thr 
                245                 250                 255     


Arg Ile Asn Ser Ala Asn Gly Leu Glu Ile Lys Ser Thr Glu Gly Gln 
            260                 265                 270         


Ser Ser Leu Thr Val Thr Asn Val Thr Glu Glu His Tyr Gly Asn Tyr 
        275                 280                 285             


Thr Cys Val Ala Ala Asn Lys Leu Gly Val Thr Asn Ala Ser Leu Val 
    290                 295                 300                 


Leu Phe Arg Pro Gly Ser Val Arg Gly Ile Asn Gly Ser Ile Ser Leu 
305                 310                 315                 320 


Ala Val Pro Leu Trp Leu Leu Ala Ala Ser Leu Leu Cys Leu Leu Ser 
                325                 330                 335     


Lys Cys 
        


<210>  2625
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  2625

Met Gly Ala Leu Gly Leu Glu Gly Arg Gly Gly Arg Leu Gln Gly Arg 
1               5                   10                  15      


Gly Ser Leu Leu Leu Ala Val Ala Gly Ala Thr Ser Leu Val Thr Leu 
            20                  25                  30          


Leu Leu Ala Val Pro Ile Thr Val Leu Ala Val Leu Ala Leu Val Pro 
        35                  40                  45              


Gln Asp Gln Gly Gly Leu Val Thr Glu Thr Ala Asp Pro Gly Ala Gln 
    50                  55                  60                  


Ala Gln Gln Gly Leu Gly Phe Gln Lys Leu Pro Glu Glu Glu Pro Glu 
65                  70                  75                  80  


Thr Asp Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile Gly Ala Pro 
                85                  90                  95      


Leu Lys Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu Gln Ala Phe 
            100                 105                 110         


Leu Thr Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu Ala Leu Pro 
        115                 120                 125             


Gln Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr Arg Gly Arg 
    130                 135                 140                 


Ala Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val Thr Leu Arg 
145                 150                 155                 160 


Ser Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly Thr Pro Glu 
                165                 170                 175     


Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu Asp Pro Ala 
            180                 185                 190         


Arg Arg Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val Gly Phe Gly 
        195                 200                 205             


Gly Leu Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val Asn Ile Ser 
    210                 215                 220                 


His Pro Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe Phe Gly Ala 
225                 230                 235                 240 


Val Met Val Gly 
                


<210>  2626
<211>  435
<212>  PRT
<213>  Homo sapiens

<400>  2626

Met Leu Leu Pro Trp Ala Thr Ser Ala Pro Gly Leu Ala Trp Gly Pro 
1               5                   10                  15      


Leu Val Leu Gly Leu Phe Gly Leu Leu Ala Ala Ser Gln Pro Gln Ala 
            20                  25                  30          


Val Pro Pro Tyr Ala Ser Glu Asn Gln Thr Cys Arg Asp Gln Glu Lys 
        35                  40                  45              


Glu Tyr Tyr Glu Pro Gln His Arg Ile Cys Cys Ser Arg Cys Pro Pro 
    50                  55                  60                  


Gly Thr Tyr Val Ser Ala Lys Cys Ser Arg Ile Arg Asp Thr Val Cys 
65                  70                  75                  80  


Ala Thr Cys Ala Glu Asn Ser Tyr Asn Glu His Trp Asn Tyr Leu Thr 
                85                  90                  95      


Ile Cys Gln Leu Cys Arg Pro Cys Asp Pro Val Met Gly Leu Glu Glu 
            100                 105                 110         


Ile Ala Pro Cys Thr Ser Lys Arg Lys Thr Gln Cys Arg Cys Gln Pro 
        115                 120                 125             


Gly Met Phe Cys Ala Ala Trp Ala Leu Glu Cys Thr His Cys Glu Leu 
    130                 135                 140                 


Leu Ser Asp Cys Pro Pro Gly Thr Glu Ala Glu Leu Lys Asp Glu Val 
145                 150                 155                 160 


Gly Lys Gly Asn Asn His Cys Val Pro Cys Lys Ala Gly His Phe Gln 
                165                 170                 175     


Asn Thr Ser Ser Pro Ser Ala Arg Cys Gln Pro His Thr Arg Cys Glu 
            180                 185                 190         


Asn Gln Gly Leu Val Glu Ala Ala Pro Gly Thr Ala Gln Ser Asp Thr 
        195                 200                 205             


Thr Cys Lys Asn Pro Leu Glu Pro Leu Pro Pro Glu Met Ser Gly Thr 
    210                 215                 220                 


Met Leu Met Leu Ala Val Leu Leu Pro Leu Ala Phe Phe Leu Leu Leu 
225                 230                 235                 240 


Ala Thr Val Phe Ser Cys Ile Trp Lys Ser His Pro Ser Leu Cys Arg 
                245                 250                 255     


Lys Leu Gly Ser Leu Leu Lys Arg Arg Pro Gln Gly Glu Gly Pro Asn 
            260                 265                 270         


Pro Val Ala Gly Ser Trp Glu Pro Pro Lys Ala His Pro Tyr Phe Pro 
        275                 280                 285             


Asp Leu Val Gln Pro Leu Leu Pro Ile Ser Gly Asp Val Ser Pro Val 
    290                 295                 300                 


Ser Thr Gly Leu Pro Ala Ala Pro Val Leu Glu Ala Gly Val Pro Gln 
305                 310                 315                 320 


Gln Gln Ser Pro Leu Asp Leu Thr Arg Glu Pro Gln Leu Glu Pro Gly 
                325                 330                 335     


Glu Gln Ser Gln Val Ala His Gly Thr Asn Gly Ile His Val Thr Gly 
            340                 345                 350         


Gly Ser Met Thr Ile Thr Gly Asn Ile Tyr Ile Tyr Asn Gly Pro Val 
        355                 360                 365             


Leu Gly Gly Pro Pro Gly Pro Gly Asp Leu Pro Ala Thr Pro Glu Pro 
    370                 375                 380                 


Pro Tyr Pro Ile Pro Glu Glu Gly Asp Pro Gly Pro Pro Gly Leu Ser 
385                 390                 395                 400 


Thr Pro His Gln Glu Asp Gly Lys Ala Trp His Leu Ala Glu Thr Glu 
                405                 410                 415     


His Cys Gly Ala Thr Pro Ser Asn Arg Gly Pro Arg Asn Gln Phe Ile 
            420                 425                 430         


Thr His Asp 
        435 


<210>  2627
<211>  710
<212>  PRT
<213>  Homo sapiens

<400>  2627

Met Lys Leu Val Phe Leu Val Leu Leu Phe Leu Gly Ala Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala Gly Arg Arg Arg Ser Val Gln Trp Cys Ala Val Ser Gln 
            20                  25                  30          


Pro Glu Ala Thr Lys Cys Phe Gln Trp Gln Arg Asn Met Arg Lys Val 
        35                  40                  45              


Arg Gly Pro Pro Val Ser Cys Ile Lys Arg Asp Ser Pro Ile Gln Cys 
    50                  55                  60                  


Ile Gln Ala Ile Ala Glu Asn Arg Ala Asp Ala Val Thr Leu Asp Gly 
65                  70                  75                  80  


Gly Phe Ile Tyr Glu Ala Gly Leu Ala Pro Tyr Lys Leu Arg Pro Val 
                85                  90                  95      


Ala Ala Glu Val Tyr Gly Thr Glu Arg Gln Pro Arg Thr His Tyr Tyr 
            100                 105                 110         


Ala Val Ala Val Val Lys Lys Gly Gly Ser Phe Gln Leu Asn Glu Leu 
        115                 120                 125             


Gln Gly Leu Lys Ser Cys His Thr Gly Leu Arg Arg Thr Ala Gly Trp 
    130                 135                 140                 


Asn Val Pro Ile Gly Thr Leu Arg Pro Phe Leu Asn Trp Thr Gly Pro 
145                 150                 155                 160 


Pro Glu Pro Ile Glu Ala Ala Val Ala Arg Phe Phe Ser Ala Ser Cys 
                165                 170                 175     


Val Pro Gly Ala Asp Lys Gly Gln Phe Pro Asn Leu Cys Arg Leu Cys 
            180                 185                 190         


Ala Gly Thr Gly Glu Asn Lys Cys Ala Phe Ser Ser Gln Glu Pro Tyr 
        195                 200                 205             


Phe Ser Tyr Ser Gly Ala Phe Lys Cys Leu Arg Asp Gly Ala Gly Asp 
    210                 215                 220                 


Val Ala Phe Ile Arg Glu Ser Thr Val Phe Glu Asp Leu Ser Asp Glu 
225                 230                 235                 240 


Ala Glu Arg Asp Glu Tyr Glu Leu Leu Cys Pro Asp Asn Thr Arg Lys 
                245                 250                 255     


Pro Val Asp Lys Phe Lys Asp Cys His Leu Ala Arg Val Pro Ser His 
            260                 265                 270         


Ala Val Val Ala Arg Ser Val Asn Gly Lys Glu Asp Ala Ile Trp Asn 
        275                 280                 285             


Leu Leu Arg Gln Ala Gln Glu Lys Phe Gly Lys Asp Lys Ser Pro Lys 
    290                 295                 300                 


Phe Gln Leu Phe Gly Ser Pro Ser Gly Gln Lys Asp Leu Leu Phe Lys 
305                 310                 315                 320 


Asp Ser Ala Ile Gly Phe Ser Arg Val Pro Pro Arg Ile Asp Ser Gly 
                325                 330                 335     


Leu Tyr Leu Gly Ser Gly Tyr Phe Thr Ala Ile Gln Asn Leu Arg Lys 
            340                 345                 350         


Ser Glu Glu Glu Val Ala Ala Arg Arg Ala Arg Val Val Trp Cys Ala 
        355                 360                 365             


Val Gly Glu Gln Glu Leu Arg Lys Cys Asn Gln Trp Ser Gly Leu Ser 
    370                 375                 380                 


Glu Gly Ser Val Thr Cys Ser Ser Ala Ser Thr Thr Glu Asp Cys Ile 
385                 390                 395                 400 


Ala Leu Val Leu Lys Gly Glu Ala Asp Ala Met Ser Leu Asp Gly Gly 
                405                 410                 415     


Tyr Val Tyr Thr Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala Glu 
            420                 425                 430         


Asn Tyr Lys Ser Gln Gln Ser Ser Asp Pro Asp Pro Asn Cys Val Asp 
        435                 440                 445             


Arg Pro Val Glu Gly Tyr Leu Ala Val Ala Val Val Arg Arg Ser Asp 
    450                 455                 460                 


Thr Ser Leu Thr Trp Asn Ser Val Lys Gly Lys Lys Ser Cys His Thr 
465                 470                 475                 480 


Ala Val Asp Arg Thr Ala Gly Trp Asn Ile Pro Met Gly Leu Leu Phe 
                485                 490                 495     


Asn Gln Thr Gly Ser Cys Lys Phe Asp Glu Tyr Phe Ser Gln Ser Cys 
            500                 505                 510         


Ala Pro Gly Ser Asp Pro Arg Ser Asn Leu Cys Ala Leu Cys Ile Gly 
        515                 520                 525             


Asp Glu Gln Gly Glu Asn Lys Cys Val Pro Asn Ser Asn Glu Arg Tyr 
    530                 535                 540                 


Tyr Gly Tyr Thr Gly Ala Phe Arg Cys Leu Ala Glu Asn Ala Gly Asp 
545                 550                 555                 560 


Val Ala Phe Val Lys Asp Val Thr Val Leu Gln Asn Thr Asp Gly Asn 
                565                 570                 575     


Asn Asn Glu Ala Trp Ala Lys Asp Leu Lys Leu Ala Asp Phe Ala Leu 
            580                 585                 590         


Leu Cys Leu Asp Gly Lys Arg Lys Pro Val Thr Glu Ala Arg Ser Cys 
        595                 600                 605             


His Leu Ala Met Ala Pro Asn His Ala Val Val Ser Arg Met Asp Lys 
    610                 615                 620                 


Val Glu Arg Leu Lys Gln Val Leu Leu His Gln Gln Ala Lys Phe Gly 
625                 630                 635                 640 


Arg Asn Gly Ser Asp Cys Pro Asp Lys Phe Cys Leu Phe Gln Ser Glu 
                645                 650                 655     


Thr Lys Asn Leu Leu Phe Asn Asp Asn Thr Glu Cys Leu Ala Arg Leu 
            660                 665                 670         


His Gly Lys Thr Thr Tyr Glu Lys Tyr Leu Gly Pro Gln Tyr Val Ala 
        675                 680                 685             


Gly Ile Thr Asn Leu Lys Lys Cys Ser Thr Ser Pro Leu Leu Glu Ala 
    690                 695                 700                 


Cys Glu Phe Leu Arg Lys 
705                 710 


<210>  2628
<211>  864
<212>  PRT
<213>  Homo sapiens

<400>  2628

Met Gly Cys Trp Gly Gln Leu Leu Val Trp Phe Gly Ala Ala Gly Ala 
1               5                   10                  15      


Ile Leu Cys Ser Ser Pro Gly Ser Gln Glu Thr Phe Leu Arg Ser Ser 
            20                  25                  30          


Pro Leu Pro Leu Ala Ser Pro Ser Pro Arg Asp Pro Lys Val Ser Ala 
        35                  40                  45              


Pro Pro Ser Ile Leu Glu Pro Ala Ser Pro Leu Asn Ser Pro Gly Thr 
    50                  55                  60                  


Glu Gly Ser Trp Leu Phe Ser Thr Cys Gly Ala Ser Gly Arg His Gly 
65                  70                  75                  80  


Pro Thr Gln Thr Gln Cys Asp Gly Ala Tyr Ala Gly Thr Ser Val Val 
                85                  90                  95      


Val Thr Val Gly Ala Ala Gly Gln Leu Arg Gly Val Gln Leu Trp Arg 
            100                 105                 110         


Val Pro Gly Pro Gly Gln Tyr Leu Ile Ser Ala Tyr Gly Ala Ala Gly 
        115                 120                 125             


Gly Lys Gly Ala Lys Asn His Leu Ser Arg Ala His Gly Val Phe Val 
    130                 135                 140                 


Ser Ala Ile Phe Ser Leu Gly Leu Gly Glu Ser Leu Tyr Ile Leu Val 
145                 150                 155                 160 


Gly Gln Gln Gly Glu Asp Ala Cys Pro Gly Gly Ser Pro Glu Ser Gln 
                165                 170                 175     


Leu Val Cys Leu Gly Glu Ser Arg Ala Val Glu Glu His Ala Ala Met 
            180                 185                 190         


Asp Gly Ser Glu Gly Val Pro Gly Ser Arg Arg Trp Ala Gly Gly Gly 
        195                 200                 205             


Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Arg Val Arg Ala Gly Glu 
    210                 215                 220                 


Leu Glu Pro Leu Leu Val Ala Ala Gly Gly Gly Gly Arg Ala Tyr Leu 
225                 230                 235                 240 


Arg Pro Arg Asp Arg Gly Arg Thr Gln Ala Ser Pro Glu Lys Leu Glu 
                245                 250                 255     


Asn Arg Ser Glu Ala Pro Gly Ser Gly Gly Arg Gly Gly Ala Ala Gly 
            260                 265                 270         


Gly Gly Gly Gly Trp Thr Ser Arg Ala Pro Ser Pro Gln Ala Gly Arg 
        275                 280                 285             


Ser Leu Gln Glu Gly Ala Glu Gly Gly Gln Gly Cys Ser Glu Ala Trp 
    290                 295                 300                 


Ala Thr Leu Gly Trp Ala Ala Ala Gly Gly Phe Gly Gly Gly Gly Gly 
305                 310                 315                 320 


Ala Cys Thr Ala Gly Gly Gly Gly Gly Gly Tyr Arg Gly Gly Asp Ala 
                325                 330                 335     


Ser Glu Thr Asp Asn Leu Trp Ala Asp Gly Glu Asp Gly Val Ser Phe 
            340                 345                 350         


Ile His Pro Ser Ser Glu Leu Phe Leu Gln Pro Leu Ala Val Thr Glu 
        355                 360                 365             


Asn His Gly Glu Val Glu Ile Arg Arg His Leu Asn Cys Ser His Cys 
    370                 375                 380                 


Pro Leu Arg Asp Cys Gln Trp Gln Ala Glu Leu Gln Leu Ala Glu Cys 
385                 390                 395                 400 


Leu Cys Pro Glu Gly Met Glu Leu Ala Val Asp Asn Val Thr Cys Met 
                405                 410                 415     


Asp Leu His Lys Pro Pro Gly Pro Leu Val Leu Met Val Ala Val Val 
            420                 425                 430         


Ala Thr Ser Thr Leu Ser Leu Leu Met Val Cys Gly Val Leu Ile Leu 
        435                 440                 445             


Val Lys Gln Lys Lys Trp Gln Gly Leu Gln Glu Met Arg Leu Pro Ser 
    450                 455                 460                 


Pro Glu Leu Glu Leu Ser Lys Leu Arg Thr Ser Ala Ile Arg Thr Ala 
465                 470                 475                 480 


Pro Asn Pro Tyr Tyr Cys Gln Val Gly Leu Gly Pro Ala Gln Ser Trp 
                485                 490                 495     


Pro Leu Pro Pro Gly Val Thr Glu Val Ser Pro Ala Asn Val Thr Leu 
            500                 505                 510         


Leu Arg Ala Leu Gly His Gly Ala Phe Gly Glu Val Tyr Glu Gly Leu 
        515                 520                 525             


Val Ile Gly Leu Pro Gly Asp Ser Ser Pro Leu Gln Val Ala Ile Lys 
    530                 535                 540                 


Thr Leu Pro Glu Leu Cys Ser Pro Gln Asp Glu Leu Asp Phe Leu Met 
545                 550                 555                 560 


Glu Ala Leu Ile Ile Ser Lys Phe Arg His Gln Asn Ile Val Arg Cys 
                565                 570                 575     


Val Gly Leu Ser Leu Arg Ala Thr Pro Arg Leu Ile Leu Leu Glu Leu 
            580                 585                 590         


Met Ser Gly Gly Asp Met Lys Ser Phe Leu Arg His Ser Arg Pro His 
        595                 600                 605             


Leu Gly Gln Pro Ser Pro Leu Val Met Arg Asp Leu Leu Gln Leu Ala 
    610                 615                 620                 


Gln Asp Ile Ala Gln Gly Cys His Tyr Leu Glu Glu Asn His Phe Ile 
625                 630                 635                 640 


His Arg Asp Ile Ala Ala Arg Asn Cys Leu Leu Ser Cys Ala Gly Pro 
                645                 650                 655     


Ser Arg Val Ala Lys Ile Gly Asp Phe Gly Met Ala Arg Asp Ile Tyr 
            660                 665                 670         


Arg Ala Ser Tyr Tyr Arg Arg Gly Asp Arg Ala Leu Leu Pro Val Lys 
        675                 680                 685             


Trp Met Pro Pro Glu Ala Phe Leu Glu Gly Ile Phe Thr Ser Lys Thr 
    690                 695                 700                 


Asp Ser Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Ser Leu Gly 
705                 710                 715                 720 


Tyr Met Pro Tyr Pro Gly Arg Thr Asn Gln Glu Val Leu Asp Phe Val 
                725                 730                 735     


Val Gly Gly Gly Arg Met Asp Pro Pro Arg Gly Cys Pro Gly Pro Val 
            740                 745                 750         


Tyr Arg Ile Met Thr Gln Cys Trp Gln His Glu Pro Glu Leu Arg Pro 
        755                 760                 765             


Ser Phe Ala Ser Ile Leu Glu Arg Leu Gln Tyr Cys Thr Gln Asp Pro 
    770                 775                 780                 


Asp Val Leu Asn Ser Leu Leu Pro Met Glu Leu Gly Pro Thr Pro Glu 
785                 790                 795                 800 


Glu Glu Gly Thr Ser Gly Leu Gly Asn Arg Ser Leu Glu Cys Leu Arg 
                805                 810                 815     


Pro Pro Gln Pro Gln Glu Leu Ser Pro Glu Lys Leu Lys Ser Trp Gly 
            820                 825                 830         


Gly Ser Pro Leu Gly Pro Trp Leu Ser Ser Gly Leu Lys Pro Leu Lys 
        835                 840                 845             


Ser Arg Gly Leu Gln Pro Gln Asn Leu Trp Asn Pro Thr Tyr Arg Ser 
    850                 855                 860                 


<210>  2629
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  2629

Met Val Ala Pro Lys Ser His Thr Asp Asp Trp Ala Pro Gly Pro Phe 
1               5                   10                  15      


Ser Ser Lys Pro Gln Arg Ser Gln Leu Gln Ile Phe Ser Ser Val Leu 
            20                  25                  30          


Gln Thr Ser Leu Leu Phe Leu Leu Met Gly Leu Arg Ala Ser Gly Lys 
        35                  40                  45              


Asp Ser Ala Pro Thr Val Val Ser Gly Ile Leu Gly Gly Ser Val Thr 
    50                  55                  60                  


Leu Pro Leu Asn Ile Ser Val Asp Thr Glu Ile Glu Asn Val Ile Trp 
65                  70                  75                  80  


Ile Gly Pro Lys Asn Ala Leu Ala Phe Ala Arg Pro Lys Glu Asn Val 
                85                  90                  95      


Thr Ile Met Val Lys Ser Tyr Leu Gly Arg Leu Asp Ile Thr Lys Trp 
            100                 105                 110         


Ser Tyr Ser Leu Cys Ile Ser Asn Leu Thr Leu Asn Asp Ala Gly Ser 
        115                 120                 125             


Tyr Lys Ala Gln Ile Asn Gln Arg Asn Phe Glu Val Thr Thr Glu Glu 
    130                 135                 140                 


Glu Phe Thr Leu Phe Val Tyr Glu Gln Leu Gln Glu Pro Gln Val Thr 
145                 150                 155                 160 


Met Lys Ser Val Lys Val Ser Glu Asn Phe Ser Cys Asn Ile Thr Leu 
                165                 170                 175     


Met Cys Ser Val Lys Gly Ala Glu Lys Ser Val Leu Tyr Ser Trp Thr 
            180                 185                 190         


Pro Arg Glu Pro His Ala Ser Glu Ser Asn Gly Gly Ser Ile Leu Thr 
        195                 200                 205             


Val Ser Arg Thr Pro Cys Asp Pro Asp Leu Pro Tyr Ile Cys Thr Ala 
    210                 215                 220                 


Gln Asn Pro Val Ser Gln Arg Ser Ser Leu Pro Val His Val Gly Gln 
225                 230                 235                 240 


Phe Cys Thr Asp Pro Gly Ala Ser Arg Gly Gly Thr Thr Gly Glu Thr 
                245                 250                 255     


Val Val Gly Val Leu Gly Glu Pro Val Thr Leu Pro Leu Ala Leu Pro 
            260                 265                 270         


Ala Cys Arg Asp Thr Glu Lys Val Val Trp Leu Phe Asn Thr Ser Ile 
        275                 280                 285             


Ile Ser Lys Glu Arg Glu Glu Ala Ala Thr Ala Asp Pro Leu Ile Lys 
    290                 295                 300                 


Ser Arg Asp Pro Tyr Lys Asn Arg Val Trp Val Ser Ser Gln Asp Cys 
305                 310                 315                 320 


Ser Leu Lys Ile Ser Gln Leu Lys Ile Glu Asp Ala Gly Pro Tyr His 
                325                 330                 335     


Ala Tyr Val Cys Ser Glu Ala Ser Ser Val Thr Ser Met Thr His Val 
            340                 345                 350         


Thr Leu Leu Ile Tyr Arg Arg Leu Arg Lys Pro Lys Ile Thr Trp Ser 
        355                 360                 365             


Leu Arg His Ser Glu Asp Gly Ile Cys Arg Ile Ser Leu Thr Cys Ser 
    370                 375                 380                 


Val Glu Asp Gly Gly Asn Thr Val Met Tyr Thr Trp Thr Pro Leu Gln 
385                 390                 395                 400 


Lys Glu Ala Val Val Ser Gln Gly Glu Ser His Leu Asn Val Ser Trp 
                405                 410                 415     


Arg Ser Ser Glu Asn His Pro Asn Leu Thr Cys Thr Ala Ser Asn Pro 
            420                 425                 430         


Val Ser Arg Ser Ser His Gln Phe Leu Ser Glu Asn Ile Cys Ser Gly 
        435                 440                 445             


Pro Glu Arg Asn Thr Lys Leu Trp Ile Gly Leu Phe Leu Met Val Cys 
    450                 455                 460                 


Leu Leu Cys Val Gly Ile Phe Ser Trp Cys Ile Trp Lys Arg Lys Gly 
465                 470                 475                 480 


Arg Cys Ser Val Pro Ala Phe Cys Ser Ser Gln Ala Glu Ala Pro Ala 
                485                 490                 495     


Asp Thr Pro Glu Pro Thr Ala Gly His Thr Leu Tyr Ser Val Leu Ser 
            500                 505                 510         


Gln Gly Tyr Glu Lys Leu Asp Thr Pro Leu Arg Pro Ala Arg Gln Gln 
        515                 520                 525             


Pro Thr Pro Thr Ser Asp Ser Ser Ser Asp Ser Asn Leu Thr Thr Glu 
    530                 535                 540                 


Glu Asp Glu Asp Arg Pro Glu Val His Lys Pro Ile Ser Gly Arg Tyr 
545                 550                 555                 560 


Glu Val Phe Asp Gln Val Thr Gln Glu Gly Ala Gly His Asp Pro Ala 
                565                 570                 575     


Pro Glu Gly Gln Ala Asp Tyr Asp Pro Val Thr Pro Tyr Val Thr Glu 
            580                 585                 590         


Val Glu Ser Val Val Gly Glu Asn Thr Met Tyr Ala Gln Val Phe Asn 
        595                 600                 605             


Leu Gln Gly Lys Thr Pro Val Ser Gln Lys Glu Glu Ser Ser Ala Thr 
    610                 615                 620                 


Ile Tyr Cys Ser Ile Arg Lys Pro Gln Val Val Pro Pro Pro Gln Gln 
625                 630                 635                 640 


Asn Asp Leu Glu Ile Pro Glu Ser Pro Thr Tyr Glu Asn Phe Thr 
                645                 650                 655 


<210>  2630
<211>  1722
<212>  PRT
<213>  Homo sapiens

<400>  2630

Met Arg Thr Gly Trp Ala Thr Pro Arg Arg Pro Ala Gly Leu Leu Met 
1               5                   10                  15      


Leu Leu Phe Trp Phe Phe Asp Leu Ala Glu Pro Ser Gly Arg Ala Ala 
            20                  25                  30          


Asn Asp Pro Phe Thr Ile Val His Gly Asn Thr Gly Lys Cys Ile Lys 
        35                  40                  45              


Pro Val Tyr Gly Trp Ile Val Ala Asp Asp Cys Asp Glu Thr Glu Asp 
    50                  55                  60                  


Lys Leu Trp Lys Trp Val Ser Gln His Arg Leu Phe His Leu His Ser 
65                  70                  75                  80  


Gln Lys Cys Leu Gly Leu Asp Ile Thr Lys Ser Val Asn Glu Leu Arg 
                85                  90                  95      


Met Phe Ser Cys Asp Ser Ser Ala Met Leu Trp Trp Lys Cys Glu His 
            100                 105                 110         


His Ser Leu Tyr Gly Ala Ala Arg Tyr Arg Leu Ala Leu Lys Asp Gly 
        115                 120                 125             


His Gly Thr Ala Ile Ser Asn Ala Ser Asp Val Trp Lys Lys Gly Gly 
    130                 135                 140                 


Ser Glu Glu Ser Leu Cys Asp Gln Pro Tyr His Glu Ile Tyr Thr Arg 
145                 150                 155                 160 


Asp Gly Asn Ser Tyr Gly Arg Pro Cys Glu Phe Pro Phe Leu Ile Asp 
                165                 170                 175     


Gly Thr Trp His His Asp Cys Ile Leu Asp Glu Asp His Ser Gly Pro 
            180                 185                 190         


Trp Cys Ala Thr Thr Leu Asn Tyr Glu Tyr Asp Arg Lys Trp Gly Ile 
        195                 200                 205             


Cys Leu Lys Pro Glu Asn Gly Cys Glu Asp Asn Trp Glu Lys Asn Glu 
    210                 215                 220                 


Gln Phe Gly Ser Cys Tyr Gln Phe Asn Thr Gln Thr Ala Leu Ser Trp 
225                 230                 235                 240 


Lys Glu Ala Tyr Val Ser Cys Gln Asn Gln Gly Ala Asp Leu Leu Ser 
                245                 250                 255     


Ile Asn Ser Ala Ala Glu Leu Thr Tyr Leu Lys Glu Lys Glu Gly Ile 
            260                 265                 270         


Ala Lys Ile Phe Trp Ile Gly Leu Asn Gln Leu Tyr Ser Ala Arg Gly 
        275                 280                 285             


Trp Glu Trp Ser Asp His Lys Pro Leu Asn Phe Leu Asn Trp Asp Pro 
    290                 295                 300                 


Asp Arg Pro Ser Ala Pro Thr Ile Gly Gly Ser Ser Cys Ala Arg Met 
305                 310                 315                 320 


Asp Ala Glu Ser Gly Leu Trp Gln Ser Phe Ser Cys Glu Ala Gln Leu 
                325                 330                 335     


Pro Tyr Val Cys Arg Lys Pro Leu Asn Asn Thr Val Glu Leu Thr Asp 
            340                 345                 350         


Val Trp Thr Tyr Ser Asp Thr Arg Cys Asp Ala Gly Trp Leu Pro Asn 
        355                 360                 365             


Asn Gly Phe Cys Tyr Leu Leu Val Asn Glu Ser Asn Ser Trp Asp Lys 
    370                 375                 380                 


Ala His Ala Lys Cys Lys Ala Phe Ser Ser Asp Leu Ile Ser Ile His 
385                 390                 395                 400 


Ser Leu Ala Asp Val Glu Val Val Val Thr Lys Leu His Asn Glu Asp 
                405                 410                 415     


Ile Lys Glu Glu Val Trp Ile Gly Leu Lys Asn Ile Asn Ile Pro Thr 
            420                 425                 430         


Leu Phe Gln Trp Ser Asp Gly Thr Glu Val Thr Leu Thr Tyr Trp Asp 
        435                 440                 445             


Glu Asn Glu Pro Asn Val Pro Tyr Asn Lys Thr Pro Asn Cys Val Ser 
    450                 455                 460                 


Tyr Leu Gly Glu Leu Gly Gln Trp Lys Val Gln Ser Cys Glu Glu Lys 
465                 470                 475                 480 


Leu Lys Tyr Val Cys Lys Arg Lys Gly Glu Lys Leu Asn Asp Ala Ser 
                485                 490                 495     


Ser Asp Lys Met Cys Pro Pro Asp Glu Gly Trp Lys Arg His Gly Glu 
            500                 505                 510         


Thr Cys Tyr Lys Ile Tyr Glu Asp Glu Val Pro Phe Gly Thr Asn Cys 
        515                 520                 525             


Asn Leu Thr Ile Thr Ser Arg Phe Glu Gln Glu Tyr Leu Asn Asp Leu 
    530                 535                 540                 


Met Lys Lys Tyr Asp Lys Ser Leu Arg Lys Tyr Phe Trp Thr Gly Leu 
545                 550                 555                 560 


Arg Asp Val Asp Ser Cys Gly Glu Tyr Asn Trp Ala Thr Val Gly Gly 
                565                 570                 575     


Arg Arg Arg Ala Val Thr Phe Ser Asn Trp Asn Phe Leu Glu Pro Ala 
            580                 585                 590         


Ser Pro Gly Gly Cys Val Ala Met Ser Thr Gly Lys Ser Val Gly Lys 
        595                 600                 605             


Trp Glu Val Lys Asp Cys Arg Ser Phe Lys Ala Leu Ser Ile Cys Lys 
    610                 615                 620                 


Lys Met Ser Gly Pro Leu Gly Pro Glu Glu Ala Ser Pro Lys Pro Asp 
625                 630                 635                 640 


Asp Pro Cys Pro Glu Gly Trp Gln Ser Phe Pro Ala Ser Leu Ser Cys 
                645                 650                 655     


Tyr Lys Val Phe His Ala Glu Arg Ile Val Arg Lys Arg Asn Trp Glu 
            660                 665                 670         


Glu Ala Glu Arg Phe Cys Gln Ala Leu Gly Ala His Leu Ser Ser Phe 
        675                 680                 685             


Ser His Val Asp Glu Ile Lys Glu Phe Leu His Phe Leu Thr Asp Gln 
    690                 695                 700                 


Phe Ser Gly Gln His Trp Leu Trp Ile Gly Leu Asn Lys Arg Ser Pro 
705                 710                 715                 720 


Asp Leu Gln Gly Ser Trp Gln Trp Ser Asp Arg Thr Pro Val Ser Thr 
                725                 730                 735     


Ile Ile Met Pro Asn Glu Phe Gln Gln Asp Tyr Asp Ile Arg Asp Cys 
            740                 745                 750         


Ala Ala Val Lys Val Phe His Arg Pro Trp Arg Arg Gly Trp His Phe 
        755                 760                 765             


Tyr Asp Asp Arg Glu Phe Ile Tyr Leu Arg Pro Phe Ala Cys Asp Thr 
    770                 775                 780                 


Lys Leu Glu Trp Val Cys Gln Ile Pro Lys Gly Arg Thr Pro Lys Thr 
785                 790                 795                 800 


Pro Asp Trp Tyr Asn Pro Asp Arg Ala Gly Ile His Gly Pro Pro Leu 
                805                 810                 815     


Ile Ile Glu Gly Ser Glu Tyr Trp Phe Val Ala Asp Leu His Leu Asn 
            820                 825                 830         


Tyr Glu Glu Ala Val Leu Tyr Cys Ala Ser Asn His Ser Phe Leu Ala 
        835                 840                 845             


Thr Ile Thr Ser Phe Val Gly Leu Lys Ala Ile Lys Asn Lys Ile Ala 
    850                 855                 860                 


Asn Ile Ser Gly Asp Gly Gln Lys Trp Trp Ile Arg Ile Ser Glu Trp 
865                 870                 875                 880 


Pro Ile Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro Trp His Arg Phe 
                885                 890                 895     


Pro Val Thr Phe Gly Glu Glu Cys Leu Tyr Met Ser Ala Lys Thr Trp 
            900                 905                 910         


Leu Ile Asp Leu Gly Lys Pro Thr Asp Cys Ser Thr Lys Leu Pro Phe 
        915                 920                 925             


Ile Cys Glu Lys Tyr Asn Val Ser Ser Leu Glu Lys Tyr Ser Pro Asp 
    930                 935                 940                 


Ser Ala Ala Lys Val Gln Cys Ser Glu Gln Trp Ile Pro Phe Gln Asn 
945                 950                 955                 960 


Lys Cys Phe Leu Lys Ile Lys Pro Val Ser Leu Thr Phe Ser Gln Ala 
                965                 970                 975     


Ser Asp Thr Cys His Ser Tyr Gly Gly Thr Leu Pro Ser Val Leu Ser 
            980                 985                 990         


Gln Ile Glu Gln Asp Phe Ile Thr  Ser Leu Leu Pro Asp  Met Glu Ala 
        995                 1000                 1005             


Thr Leu  Trp Ile Gly Leu Arg  Trp Thr Ala Tyr Glu  Lys Ile Asn 
    1010                 1015                 1020             


Lys Trp  Thr Asp Asn Arg Glu  Leu Thr Tyr Ser Asn  Phe His Pro 
    1025                 1030                 1035             


Leu Leu  Val Ser Gly Arg Leu  Arg Ile Pro Glu Asn  Phe Phe Glu 
    1040                 1045                 1050             


Glu Glu  Ser Arg Tyr His Cys  Ala Leu Ile Leu Asn  Leu Gln Lys 
    1055                 1060                 1065             


Ser Pro  Phe Thr Gly Thr Trp  Asn Phe Thr Ser Cys  Ser Glu Arg 
    1070                 1075                 1080             


His Phe  Val Ser Leu Cys Gln  Lys Tyr Ser Glu Val  Lys Ser Arg 
    1085                 1090                 1095             


Gln Thr  Leu Gln Asn Ala Ser  Glu Thr Val Lys Tyr  Leu Asn Asn 
    1100                 1105                 1110             


Leu Tyr  Lys Ile Ile Pro Lys  Thr Leu Thr Trp His  Ser Ala Lys 
    1115                 1120                 1125             


Arg Glu  Cys Leu Lys Ser Asn  Met Gln Leu Val Ser  Ile Thr Asp 
    1130                 1135                 1140             


Pro Tyr  Gln Gln Ala Phe Leu  Ser Val Gln Ala Leu  Leu His Asn 
    1145                 1150                 1155             


Ser Ser  Leu Trp Ile Gly Leu  Phe Ser Gln Asp Asp  Glu Leu Asn 
    1160                 1165                 1170             


Phe Gly  Trp Ser Asp Gly Lys  Arg Leu His Phe Ser  Arg Trp Ala 
    1175                 1180                 1185             


Glu Thr  Asn Gly Gln Leu Glu  Asp Cys Val Val Leu  Asp Thr Asp 
    1190                 1195                 1200             


Gly Phe  Trp Lys Thr Val Asp  Cys Asn Asp Asn Gln  Pro Gly Ala 
    1205                 1210                 1215             


Ile Cys  Tyr Tyr Ser Gly Asn  Glu Thr Glu Lys Glu  Val Lys Pro 
    1220                 1225                 1230             


Val Asp  Ser Val Lys Cys Pro  Ser Pro Val Leu Asn  Thr Pro Trp 
    1235                 1240                 1245             


Ile Pro  Phe Gln Asn Cys Cys  Tyr Asn Phe Ile Ile  Thr Lys Asn 
    1250                 1255                 1260             


Arg His  Met Ala Thr Thr Gln  Asp Glu Val His Thr  Lys Cys Gln 
    1265                 1270                 1275             


Lys Leu  Asn Pro Lys Ser His  Ile Leu Ser Ile Arg  Asp Glu Lys 
    1280                 1285                 1290             


Glu Asn  Asn Phe Val Leu Glu  Gln Leu Leu Tyr Phe  Asn Tyr Met 
    1295                 1300                 1305             


Ala Ser  Trp Val Met Leu Gly  Ile Thr Tyr Arg Asn  Lys Ser Leu 
    1310                 1315                 1320             


Met Trp  Phe Asp Lys Thr Pro  Leu Ser Tyr Thr His  Trp Arg Ala 
    1325                 1330                 1335             


Gly Arg  Pro Thr Ile Lys Asn  Glu Lys Phe Leu Ala  Gly Leu Ser 
    1340                 1345                 1350             


Thr Asp  Gly Phe Trp Asp Ile  Gln Thr Phe Lys Val  Ile Glu Glu 
    1355                 1360                 1365             


Ala Val  Tyr Phe His Gln His  Ser Ile Leu Ala Cys  Lys Ile Glu 
    1370                 1375                 1380             


Met Val  Asp Tyr Lys Glu Glu  Tyr Asn Thr Thr Leu  Pro Gln Phe 
    1385                 1390                 1395             


Met Pro  Tyr Glu Asp Gly Ile  Tyr Ser Val Ile Gln  Lys Lys Val 
    1400                 1405                 1410             


Thr Trp  Tyr Glu Ala Leu Asn  Met Cys Ser Gln Ser  Gly Gly His 
    1415                 1420                 1425             


Leu Ala  Ser Val His Asn Gln  Asn Gly Gln Leu Phe  Leu Glu Asp 
    1430                 1435                 1440             


Ile Val  Lys Arg Asp Gly Phe  Pro Leu Trp Val Gly  Leu Ser Ser 
    1445                 1450                 1455             


His Asp  Gly Ser Glu Ser Ser  Phe Glu Trp Ser Asp  Gly Ser Thr 
    1460                 1465                 1470             


Phe Asp  Tyr Ile Pro Trp Lys  Gly Gln Thr Ser Pro  Gly Asn Cys 
    1475                 1480                 1485             


Val Leu  Leu Asp Pro Lys Gly  Thr Trp Lys His Glu  Lys Cys Asn 
    1490                 1495                 1500             


Ser Val  Lys Asp Gly Ala Ile  Cys Tyr Lys Pro Thr  Lys Ser Lys 
    1505                 1510                 1515             


Lys Leu  Ser Arg Leu Thr Tyr  Ser Ser Arg Cys Pro  Ala Ala Lys 
    1520                 1525                 1530             


Glu Asn  Gly Ser Arg Trp Ile  Gln Tyr Lys Gly His  Cys Tyr Lys 
    1535                 1540                 1545             


Ser Asp  Gln Ala Leu His Ser  Phe Ser Glu Ala Lys  Lys Leu Cys 
    1550                 1555                 1560             


Ser Lys  His Asp His Ser Ala  Thr Ile Val Ser Ile  Lys Asp Glu 
    1565                 1570                 1575             


Asp Glu  Asn Lys Phe Val Ser  Arg Leu Met Arg Glu  Asn Asn Asn 
    1580                 1585                 1590             


Ile Thr  Met Arg Val Trp Leu  Gly Leu Ser Gln His  Ser Val Asp 
    1595                 1600                 1605             


Gln Ser  Trp Ser Trp Leu Asp  Gly Ser Glu Val Thr  Phe Val Lys 
    1610                 1615                 1620             


Trp Glu  Asn Lys Ser Lys Ser  Gly Val Gly Arg Cys  Ser Met Leu 
    1625                 1630                 1635             


Ile Ala  Ser Asn Glu Thr Trp  Lys Lys Val Glu Cys  Glu His Gly 
    1640                 1645                 1650             


Phe Gly  Arg Val Val Cys Lys  Val Pro Leu Gly Pro  Asp Tyr Thr 
    1655                 1660                 1665             


Ala Ile  Ala Ile Ile Val Ala  Thr Leu Ser Ile Leu  Val Leu Met 
    1670                 1675                 1680             


Gly Gly  Leu Ile Trp Phe Leu  Phe Gln Arg His Arg  Leu His Leu 
    1685                 1690                 1695             


Ala Gly  Phe Ser Ser Val Arg  Tyr Ala Gln Gly Val  Asn Glu Asp 
    1700                 1705                 1710             


Glu Ile  Met Leu Pro Ser Phe  His Asp 
    1715                 1720         


<210>  2631
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  2631

Met Ala Arg Gly Pro Gly Leu Ala Pro Pro Pro Leu Arg Leu Pro Leu 
1               5                   10                  15      


Leu Leu Leu Val Leu Ala Ala Val Thr Gly His Thr Ala Ala Gln Asp 
            20                  25                  30          


Asn Cys Thr Cys Pro Thr Asn Lys Met Thr Val Cys Ser Pro Asp Gly 
        35                  40                  45              


Pro Gly Gly Arg Cys Gln Cys Arg Ala Leu Gly Ser Gly Met Ala Val 
    50                  55                  60                  


Asp Cys Ser Thr Leu Thr Ser Lys Cys Leu Leu Leu Lys Ala Arg Met 
65                  70                  75                  80  


Ser Ala Pro Lys Asn Ala Arg Thr Leu Val Arg Pro Ser Glu His Ala 
                85                  90                  95      


Leu Val Asp Asn Asp Gly Leu Tyr Asp Pro Asp Cys Asp Pro Glu Gly 
            100                 105                 110         


Arg Phe Lys Ala Arg Gln Cys Asn Gln Thr Ser Val Cys Trp Cys Val 
        115                 120                 125             


Asn Ser Val Gly Val Arg Arg Thr Asp Lys Gly Asp Leu Ser Leu Arg 
    130                 135                 140                 


Cys Asp Glu Leu Val Arg Thr His His Ile Leu Ile Asp Leu Arg His 
145                 150                 155                 160 


Arg Pro Thr Ala Gly Ala Phe Asn His Ser Asp Leu Asp Ala Glu Leu 
                165                 170                 175     


Arg Arg Leu Phe Arg Glu Arg Tyr Arg Leu His Pro Lys Phe Val Ala 
            180                 185                 190         


Ala Val His Tyr Glu Gln Pro Thr Ile Gln Ile Glu Leu Arg Gln Asn 
        195                 200                 205             


Thr Ser Gln Lys Ala Ala Gly Asp Val Asp Ile Gly Asp Ala Ala Tyr 
    210                 215                 220                 


Tyr Phe Glu Arg Asp Ile Lys Gly Glu Ser Leu Phe Gln Gly Arg Gly 
225                 230                 235                 240 


Gly Leu Asp Leu Arg Val Arg Gly Glu Pro Leu Gln Val Glu Arg Thr 
                245                 250                 255     


Leu Ile Tyr Tyr Leu Asp Glu Ile Pro Pro Lys Phe Ser Met Lys Arg 
            260                 265                 270         


Leu Thr Ala Gly Leu Ile Ala Val Ile Val Val Val Val Val Ala Leu 
        275                 280                 285             


Val Ala Gly Met Ala Val Leu Val Ile Thr Asn Arg Arg Lys Ser Gly 
    290                 295                 300                 


Lys Tyr Lys Lys Val Glu Ile Lys Glu Leu Gly Glu Leu Arg Lys Glu 
305                 310                 315                 320 


Pro Ser Leu 
            


<210>  2632
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  2632

Met Ala Pro Pro Gln Val Leu Ala Phe Gly Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Thr Ala Thr Phe Ala Ala Ala Gln Glu Glu Cys Val Cys Glu Asn Tyr 
            20                  25                  30          


Lys Leu Ala Val Asn Cys Phe Val Asn Asn Asn Arg Gln Cys Gln Cys 
        35                  40                  45              


Thr Ser Val Gly Ala Gln Asn Thr Val Ile Cys Ser Lys Leu Ala Ala 
    50                  55                  60                  


Lys Cys Leu Val Met Lys Ala Glu Met Asn Gly Ser Lys Leu Gly Arg 
65                  70                  75                  80  


Arg Ala Lys Pro Glu Gly Ala Leu Gln Asn Asn Asp Gly Leu Tyr Asp 
                85                  90                  95      


Pro Asp Cys Asp Glu Ser Gly Leu Phe Lys Ala Lys Gln Cys Asn Gly 
            100                 105                 110         


Thr Ser Met Cys Trp Cys Val Asn Thr Ala Gly Val Arg Arg Thr Asp 
        115                 120                 125             


Lys Asp Thr Glu Ile Thr Cys Ser Glu Arg Val Arg Thr Tyr Trp Ile 
    130                 135                 140                 


Ile Ile Glu Leu Lys His Lys Ala Arg Glu Lys Pro Tyr Asp Ser Lys 
145                 150                 155                 160 


Ser Leu Arg Thr Ala Leu Gln Lys Glu Ile Thr Thr Arg Tyr Gln Leu 
                165                 170                 175     


Asp Pro Lys Phe Ile Thr Ser Ile Leu Tyr Glu Asn Asn Val Ile Thr 
            180                 185                 190         


Ile Asp Leu Val Gln Asn Ser Ser Gln Lys Thr Gln Asn Asp Val Asp 
        195                 200                 205             


Ile Ala Asp Val Ala Tyr Tyr Phe Glu Lys Asp Val Lys Gly Glu Ser 
    210                 215                 220                 


Leu Phe His Ser Lys Lys Met Asp Leu Thr Val Asn Gly Glu Gln Leu 
225                 230                 235                 240 


Asp Leu Asp Pro Gly Gln Thr Leu Ile Tyr Tyr Val Asp Glu Lys Ala 
                245                 250                 255     


Pro Glu Phe Ser Met Gln Gly Leu Lys Ala Gly Val Ile Ala Val Ile 
            260                 265                 270         


Val Val Val Val Ile Ala Val Val Ala Gly Ile Val Val Leu Val Ile 
        275                 280                 285             


Ser Arg Lys Lys Arg Met Ala Lys Tyr Glu Lys Ala Glu Ile Lys Glu 
    290                 295                 300                 


Met Gly Glu Met His Arg Glu Leu Asn Ala 
305                 310                 


<210>  2633
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  2633

Met Phe Pro Phe Tyr Ser Cys Trp Arg Thr Gly Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Val Ala Val Arg Glu Ser Trp Gln Thr Glu Glu Lys Thr Cys 
            20                  25                  30          


Asp Leu Val Gly Glu Lys Gly Lys Glu Ser Glu Lys Glu Leu Ala Leu 
        35                  40                  45              


Val Lys Arg Leu Lys Pro Leu Phe Asn Lys Ser Phe Glu Ser Thr Val 
    50                  55                  60                  


Gly Gln Gly Ser Asp Thr Tyr Ile Tyr Ile Phe Arg Val Cys Arg Glu 
65                  70                  75                  80  


Ala Gly Asn His Thr Ser Gly Ala Gly Leu Val Gln Ile Asn Lys Ser 
                85                  90                  95      


Asn Gly Lys Glu Thr Val Val Gly Arg Leu Asn Glu Thr His Ile Phe 
            100                 105                 110         


Asn Gly Ser Asn Trp Ile Met Leu Ile Tyr Lys Gly Gly Asp Glu Tyr 
        115                 120                 125             


Asp Asn His Cys Gly Lys Glu Gln Arg Arg Ala Val Val Met Ile Ser 
    130                 135                 140                 


Cys Asn Arg His Thr Leu Ala Asp Asn Phe Asn Pro Val Ser Glu Glu 
145                 150                 155                 160 


Arg Gly Lys Val Gln Asp Cys Phe Tyr Leu Phe Glu Met Asp Ser Ser 
                165                 170                 175     


Leu Ala Cys Ser Pro Glu Ile Ser His Leu Ser Val Gly Ser Ile Leu 
            180                 185                 190         


Leu Val Thr Phe Ala Ser Leu Val Ala Val Tyr Val Val Gly Gly Phe 
        195                 200                 205             


Leu Tyr Gln Arg Leu Val Val Gly Ala Lys Gly Met Glu Gln Phe Pro 
    210                 215                 220                 


His Leu Ala Phe Trp Gln Asp Leu Gly Asn Leu Val Ala Asp Gly Cys 
225                 230                 235                 240 


Asp Phe Val Cys Arg Ser Lys Pro Arg Asn Val Pro Ala Ala Tyr Arg 
                245                 250                 255     


Gly Val Gly Asp Asp Gln Leu Gly Glu Glu Ser Glu Glu Arg Asp Asp 
            260                 265                 270         


His Leu Leu Pro Met 
        275         


<210>  2634
<211>  626
<212>  PRT
<213>  Homo sapiens

<400>  2634

Met Ile Phe Leu Thr Ala Leu Pro Leu Phe Trp Ile Met Ile Ser Ala 
1               5                   10                  15      


Ser Arg Gly Gly His Trp Gly Ala Trp Met Pro Ser Ser Ile Ser Ala 
            20                  25                  30          


Phe Glu Gly Thr Cys Val Ser Ile Pro Cys Arg Phe Asp Phe Pro Asp 
        35                  40                  45              


Glu Leu Arg Pro Ala Val Val His Gly Val Trp Tyr Phe Asn Ser Pro 
    50                  55                  60                  


Tyr Pro Lys Asn Tyr Pro Pro Val Val Phe Lys Ser Arg Thr Gln Val 
65                  70                  75                  80  


Val His Glu Ser Phe Gln Gly Arg Ser Arg Leu Leu Gly Asp Leu Gly 
                85                  90                  95      


Leu Arg Asn Cys Thr Leu Leu Leu Ser Asn Val Ser Pro Glu Leu Gly 
            100                 105                 110         


Gly Lys Tyr Tyr Phe Arg Gly Asp Leu Gly Gly Tyr Asn Gln Tyr Thr 
        115                 120                 125             


Phe Ser Glu His Ser Val Leu Asp Ile Val Asn Thr Pro Asn Ile Val 
    130                 135                 140                 


Val Pro Pro Glu Val Val Ala Gly Thr Glu Val Glu Val Ser Cys Met 
145                 150                 155                 160 


Val Pro Asp Asn Cys Pro Glu Leu Arg Pro Glu Leu Ser Trp Leu Gly 
                165                 170                 175     


His Glu Gly Leu Gly Glu Pro Ala Val Leu Gly Arg Leu Arg Glu Asp 
            180                 185                 190         


Glu Gly Thr Trp Val Gln Val Ser Leu Leu His Phe Val Pro Thr Arg 
        195                 200                 205             


Glu Ala Asn Gly His Arg Leu Gly Cys Gln Ala Ser Phe Pro Asn Thr 
    210                 215                 220                 


Thr Leu Gln Phe Glu Gly Tyr Ala Ser Met Asp Val Lys Tyr Pro Pro 
225                 230                 235                 240 


Val Ile Val Glu Met Asn Ser Ser Val Glu Ala Ile Glu Gly Ser His 
                245                 250                 255     


Val Ser Leu Leu Cys Gly Ala Asp Ser Asn Pro Pro Pro Leu Leu Thr 
            260                 265                 270         


Trp Met Arg Asp Gly Thr Val Leu Arg Glu Ala Val Ala Glu Ser Leu 
        275                 280                 285             


Leu Leu Glu Leu Glu Glu Val Thr Pro Ala Glu Asp Gly Val Tyr Ala 
    290                 295                 300                 


Cys Leu Ala Glu Asn Ala Tyr Gly Gln Asp Asn Arg Thr Val Gly Leu 
305                 310                 315                 320 


Ser Val Met Tyr Ala Pro Trp Lys Pro Thr Val Asn Gly Thr Met Val 
                325                 330                 335     


Ala Val Glu Gly Glu Thr Val Ser Ile Leu Cys Ser Thr Gln Ser Asn 
            340                 345                 350         


Pro Asp Pro Ile Leu Thr Ile Phe Lys Glu Lys Gln Ile Leu Ser Thr 
        355                 360                 365             


Val Ile Tyr Glu Ser Glu Leu Gln Leu Glu Leu Pro Ala Val Ser Pro 
    370                 375                 380                 


Glu Asp Asp Gly Glu Tyr Trp Cys Val Ala Glu Asn Gln Tyr Gly Gln 
385                 390                 395                 400 


Arg Ala Thr Ala Phe Asn Leu Ser Val Glu Phe Ala Pro Val Leu Leu 
                405                 410                 415     


Leu Glu Ser His Cys Ala Ala Ala Arg Asp Thr Val Gln Cys Leu Cys 
            420                 425                 430         


Val Val Lys Ser Asn Pro Glu Pro Ser Val Ala Phe Glu Leu Pro Ser 
        435                 440                 445             


Arg Asn Val Thr Val Asn Glu Ser Glu Arg Glu Phe Val Tyr Ser Glu 
    450                 455                 460                 


Arg Ser Gly Leu Val Leu Thr Ser Ile Leu Thr Leu Arg Gly Gln Ala 
465                 470                 475                 480 


Gln Ala Pro Pro Arg Val Ile Cys Thr Ala Arg Asn Leu Tyr Gly Ala 
                485                 490                 495     


Lys Ser Leu Glu Leu Pro Phe Gln Gly Ala His Arg Leu Met Trp Ala 
            500                 505                 510         


Lys Ile Gly Pro Val Gly Ala Val Val Ala Phe Ala Ile Leu Ile Ala 
        515                 520                 525             


Ile Val Cys Tyr Ile Thr Gln Thr Arg Arg Lys Lys Asn Val Thr Glu 
    530                 535                 540                 


Ser Pro Ser Phe Ser Ala Gly Asp Asn Pro Pro Val Leu Phe Ser Ser 
545                 550                 555                 560 


Asp Phe Arg Ile Ser Gly Ala Pro Glu Lys Tyr Glu Ser Glu Arg Arg 
                565                 570                 575     


Leu Gly Ser Glu Arg Arg Leu Leu Gly Leu Arg Gly Glu Pro Pro Glu 
            580                 585                 590         


Leu Asp Leu Ser Tyr Ser His Ser Asp Leu Gly Lys Arg Pro Thr Lys 
        595                 600                 605             


Asp Ser Tyr Thr Leu Thr Glu Glu Leu Ala Glu Tyr Ala Glu Ile Arg 
    610                 615                 620                 


Val Lys 
625     


<210>  2635
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  2635

Met Ala Pro Ala Ala Ala Thr Gly Gly Ser Thr Leu Pro Ser Gly Phe 
1               5                   10                  15      


Ser Val Phe Thr Thr Leu Pro Asp Leu Leu Phe Ile Phe Glu Phe Ile 
            20                  25                  30          


Phe Gly Gly Leu Val Trp Ile Leu Val Ala Ser Ser Leu Val Pro Trp 
        35                  40                  45              


Pro Leu Val Gln Gly Trp Val Met Phe Val Ser Val Phe Cys Phe Val 
    50                  55                  60                  


Ala Thr Thr Thr Leu Ile Ile Leu Tyr Ile Ile Gly Ala His Gly Gly 
65                  70                  75                  80  


Glu Thr Ser Trp Val Thr Leu Asp Ala Ala Tyr His Cys Thr Ala Ala 
                85                  90                  95      


Leu Phe Tyr Leu Ser Ala Ser Val Leu Glu Ala Leu Ala Thr Ile Thr 
            100                 105                 110         


Met Gln Asp Gly Phe Thr Tyr Arg His Tyr His Glu Asn Ile Ala Ala 
        115                 120                 125             


Val Val Phe Ser Tyr Ile Ala Thr Leu Leu Tyr Val Val His Ala Val 
    130                 135                 140                 


Phe Ser Leu Ile Arg Trp Lys Ser Ser 
145                 150             


<210>  2636
<211>  1144
<212>  PRT
<213>  Homo sapiens

<400>  2636

Met Lys Leu Ser Arg Gln Phe Thr Val Phe Gly Ser Ala Ile Phe Cys 
1               5                   10                  15      


Val Val Ile Phe Ser Leu Tyr Leu Met Leu Asp Arg Gly His Leu Asp 
            20                  25                  30          


Tyr Pro Arg Asn Pro Arg Arg Glu Gly Ser Phe Pro Gln Gly Gln Leu 
        35                  40                  45              


Ser Met Leu Gln Glu Lys Ile Asp His Leu Glu Arg Leu Leu Ala Glu 
    50                  55                  60                  


Asn Asn Glu Ile Ile Ser Asn Ile Arg Asp Ser Val Ile Asn Leu Ser 
65                  70                  75                  80  


Glu Ser Val Glu Asp Gly Pro Lys Ser Ser Gln Ser Asn Phe Ser Gln 
                85                  90                  95      


Gly Ala Gly Ser His Leu Leu Pro Ser Gln Leu Ser Leu Ser Val Asp 
            100                 105                 110         


Thr Ala Asp Cys Leu Phe Ala Ser Gln Ser Gly Ser His Asn Ser Asp 
        115                 120                 125             


Val Gln Met Leu Asp Val Tyr Ser Leu Ile Ser Phe Asp Asn Pro Asp 
    130                 135                 140                 


Gly Gly Val Trp Lys Gln Gly Phe Asp Ile Thr Tyr Glu Ser Asn Glu 
145                 150                 155                 160 


Trp Asp Thr Glu Pro Leu Gln Val Phe Val Val Pro His Ser His Asn 
                165                 170                 175     


Asp Pro Gly Trp Leu Lys Thr Phe Asn Asp Tyr Phe Arg Asp Lys Thr 
            180                 185                 190         


Gln Tyr Ile Phe Asn Asn Met Val Leu Lys Leu Lys Glu Asp Ser Arg 
        195                 200                 205             


Arg Lys Phe Ile Trp Ser Glu Ile Ser Tyr Leu Ser Lys Trp Trp Asp 
    210                 215                 220                 


Ile Ile Asp Ile Gln Lys Lys Asp Ala Val Lys Ser Leu Ile Glu Asn 
225                 230                 235                 240 


Gly Gln Leu Glu Ile Val Thr Gly Gly Trp Val Met Pro Asp Glu Ala 
                245                 250                 255     


Thr Pro His Tyr Phe Ala Leu Ile Asp Gln Leu Ile Glu Gly His Gln 
            260                 265                 270         


Trp Leu Glu Asn Asn Ile Gly Val Lys Pro Arg Ser Gly Trp Ala Ile 
        275                 280                 285             


Asp Pro Phe Gly His Ser Pro Thr Met Ala Tyr Leu Leu Asn Arg Ala 
    290                 295                 300                 


Gly Leu Ser His Met Leu Ile Gln Arg Val His Tyr Ala Val Lys Lys 
305                 310                 315                 320 


His Phe Ala Leu His Lys Thr Leu Glu Phe Phe Trp Arg Gln Asn Trp 
                325                 330                 335     


Asp Leu Gly Ser Val Thr Asp Ile Leu Cys His Met Met Pro Phe Tyr 
            340                 345                 350         


Ser Tyr Asp Ile Pro His Thr Cys Gly Pro Asp Pro Lys Ile Cys Cys 
        355                 360                 365             


Gln Phe Asp Phe Lys Arg Leu Pro Gly Gly Arg Phe Gly Cys Pro Trp 
    370                 375                 380                 


Gly Val Pro Pro Glu Thr Ile His Pro Gly Asn Val Gln Ser Arg Ala 
385                 390                 395                 400 


Arg Met Leu Leu Asp Gln Tyr Arg Lys Lys Ser Lys Leu Phe Arg Thr 
                405                 410                 415     


Lys Val Leu Leu Ala Pro Leu Gly Asp Asp Phe Arg Tyr Cys Glu Tyr 
            420                 425                 430         


Thr Glu Trp Asp Leu Gln Phe Lys Asn Tyr Gln Gln Leu Phe Asp Tyr 
        435                 440                 445             


Met Asn Ser Gln Ser Lys Phe Lys Val Lys Ile Gln Phe Gly Thr Leu 
    450                 455                 460                 


Ser Asp Phe Phe Asp Ala Leu Asp Lys Ala Asp Glu Thr Gln Arg Asp 
465                 470                 475                 480 


Lys Gly Gln Ser Met Phe Pro Val Leu Ser Gly Asp Phe Phe Thr Tyr 
                485                 490                 495     


Ala Asp Arg Asp Asp His Tyr Trp Ser Gly Tyr Phe Thr Ser Arg Pro 
            500                 505                 510         


Phe Tyr Lys Arg Met Asp Arg Ile Met Glu Ser His Leu Arg Ala Ala 
        515                 520                 525             


Glu Ile Leu Tyr Tyr Phe Ala Leu Arg Gln Ala His Lys Tyr Lys Ile 
    530                 535                 540                 


Asn Lys Phe Leu Ser Ser Ser Leu Tyr Thr Ala Leu Thr Glu Ala Arg 
545                 550                 555                 560 


Arg Asn Leu Gly Leu Phe Gln His His Asp Ala Ile Thr Gly Thr Ala 
                565                 570                 575     


Lys Asp Trp Val Val Val Asp Tyr Gly Thr Arg Leu Phe His Ser Leu 
            580                 585                 590         


Met Val Leu Glu Lys Ile Ile Gly Asn Ser Ala Phe Leu Leu Ile Leu 
        595                 600                 605             


Lys Asp Lys Leu Thr Tyr Asp Ser Tyr Ser Pro Asp Thr Phe Leu Glu 
    610                 615                 620                 


Met Asp Leu Lys Gln Lys Ser Gln Asp Ser Leu Pro Gln Lys Asn Ile 
625                 630                 635                 640 


Ile Arg Leu Ser Ala Glu Pro Arg Tyr Leu Val Val Tyr Asn Pro Leu 
                645                 650                 655     


Glu Gln Asp Arg Ile Ser Leu Val Ser Val Tyr Val Ser Ser Pro Thr 
            660                 665                 670         


Val Gln Val Phe Ser Ala Ser Gly Lys Pro Val Glu Val Gln Val Ser 
        675                 680                 685             


Ala Val Trp Asp Thr Ala Asn Thr Ile Ser Glu Thr Ala Tyr Glu Ile 
    690                 695                 700                 


Ser Phe Arg Ala His Ile Pro Pro Leu Gly Leu Lys Val Tyr Lys Ile 
705                 710                 715                 720 


Leu Glu Ser Ala Ser Ser Asn Ser His Leu Ala Asp Tyr Val Leu Tyr 
                725                 730                 735     


Lys Asn Lys Val Glu Asp Ser Gly Ile Phe Thr Ile Lys Asn Met Ile 
            740                 745                 750         


Asn Thr Glu Glu Gly Ile Thr Leu Glu Asn Ser Phe Val Leu Leu Arg 
        755                 760                 765             


Phe Asp Gln Thr Gly Leu Met Lys Gln Met Met Thr Lys Glu Asp Gly 
    770                 775                 780                 


Lys His His Glu Val Asn Val Gln Phe Ser Trp Tyr Gly Thr Thr Ile 
785                 790                 795                 800 


Lys Arg Asp Lys Ser Gly Ala Tyr Leu Phe Leu Pro Asp Gly Asn Ala 
                805                 810                 815     


Lys Pro Tyr Val Tyr Thr Thr Pro Pro Phe Val Arg Val Thr His Gly 
            820                 825                 830         


Arg Ile Tyr Ser Glu Val Thr Cys Phe Phe Asp His Val Thr His Arg 
        835                 840                 845             


Val Arg Leu Tyr His Ile Gln Gly Ile Glu Gly Gln Ser Val Glu Val 
    850                 855                 860                 


Ser Asn Ile Val Asp Ile Arg Lys Val Tyr Asn Arg Glu Ile Ala Met 
865                 870                 875                 880 


Lys Ile Ser Ser Asp Ile Lys Ser Gln Asn Arg Phe Tyr Thr Asp Leu 
                885                 890                 895     


Asn Gly Tyr Gln Ile Gln Pro Arg Met Thr Leu Ser Lys Leu Pro Leu 
            900                 905                 910         


Gln Ala Asn Val Tyr Pro Met Thr Thr Met Ala Tyr Ile Gln Asp Ala 
        915                 920                 925             


Lys His Arg Leu Thr Leu Leu Ser Ala Gln Ser Leu Gly Val Ser Ser 
    930                 935                 940                 


Leu Asn Ser Gly Gln Ile Glu Val Ile Met Asp Arg Arg Leu Met Gln 
945                 950                 955                 960 


Asp Asp Asn Arg Gly Leu Glu Gln Gly Ile Gln Asp Asn Lys Ile Thr 
                965                 970                 975     


Ala Asn Leu Phe Arg Ile Leu Leu Glu Lys Arg Ser Ala Val Asn Thr 
            980                 985                 990         


Glu Glu Glu Lys Lys Ser Val Ser  Tyr Pro Ser Leu Leu  Ser His Ile 
        995                 1000                 1005             


Thr Ser  Ser Leu Met Asn His  Pro Val Ile Pro Met  Ala Asn Lys 
    1010                 1015                 1020             


Phe Ser  Ser Pro Thr Leu Glu  Leu Gln Gly Glu Phe  Ser Pro Leu 
    1025                 1030                 1035             


Gln Ser  Ser Leu Pro Cys Asp  Ile His Leu Val Asn  Leu Arg Thr 
    1040                 1045                 1050             


Ile Gln  Ser Lys Val Gly Asn  Gly His Ser Asn Glu  Ala Ala Leu 
    1055                 1060                 1065             


Ile Leu  His Arg Lys Gly Phe  Asp Cys Arg Phe Ser  Ser Lys Gly 
    1070                 1075                 1080             


Thr Gly  Leu Phe Cys Ser Thr  Thr Gln Gly Lys Ile  Leu Val Gln 
    1085                 1090                 1095             


Lys Leu  Leu Asn Lys Phe Ile  Val Glu Ser Leu Thr  Pro Ser Ser 
    1100                 1105                 1110             


Leu Ser  Leu Met His Ser Pro  Pro Gly Thr Gln Asn  Ile Ser Glu 
    1115                 1120                 1125             


Ile Asn  Leu Ser Pro Met Glu  Ile Ser Thr Phe Arg  Ile Gln Leu 
    1130                 1135                 1140             


Arg 
    


<210>  2637
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  2637

Met Asp Gly Ser Asn Val Thr Ser Phe Val Val Glu Glu Pro Thr Asn 
1               5                   10                  15      


Ile Ser Thr Gly Arg Asn Ala Ser Val Gly Asn Ala His Arg Gln Ile 
            20                  25                  30          


Pro Ile Val His Trp Val Ile Met Ser Ile Ser Pro Val Gly Phe Val 
        35                  40                  45              


Glu Asn Gly Ile Leu Leu Trp Phe Leu Cys Phe Arg Met Arg Arg Asn 
    50                  55                  60                  


Pro Phe Thr Val Tyr Ile Thr His Leu Ser Ile Ala Asp Ile Ser Leu 
65                  70                  75                  80  


Leu Phe Cys Ile Phe Ile Leu Ser Ile Asp Tyr Ala Leu Asp Tyr Glu 
                85                  90                  95      


Leu Ser Ser Gly His Tyr Tyr Thr Ile Val Thr Leu Ser Val Thr Phe 
            100                 105                 110         


Leu Phe Gly Tyr Asn Thr Gly Leu Tyr Leu Leu Thr Ala Ile Ser Val 
        115                 120                 125             


Glu Arg Cys Leu Ser Val Leu Tyr Pro Ile Trp Tyr Arg Cys His Arg 
    130                 135                 140                 


Pro Lys Tyr Gln Ser Ala Leu Val Cys Ala Leu Leu Trp Ala Leu Ser 
145                 150                 155                 160 


Cys Leu Val Thr Thr Met Glu Tyr Val Met Cys Ile Asp Arg Glu Glu 
                165                 170                 175     


Glu Ser His Ser Arg Asn Asp Cys Arg Ala Val Ile Ile Phe Ile Ala 
            180                 185                 190         


Ile Leu Ser Phe Leu Val Phe Thr Pro Leu Met Leu Val Ser Ser Thr 
        195                 200                 205             


Ile Leu Val Val Lys Ile Arg Lys Asn Thr Trp Ala Ser His Ser Ser 
    210                 215                 220                 


Lys Leu Tyr Ile Val Ile Met Val Thr Ile Ile Ile Phe Leu Ile Phe 
225                 230                 235                 240 


Ala Met Pro Met Arg Leu Leu Tyr Leu Leu Tyr Tyr Glu Tyr Trp Ser 
                245                 250                 255     


Thr Phe Gly Asn Leu His His Ile Ser Leu Leu Phe Ser Thr Ile Asn 
            260                 265                 270         


Ser Ser Ala Asn Pro Phe Ile Tyr Phe Phe Val Gly Ser Ser Lys Lys 
        275                 280                 285             


Lys Arg Phe Lys Glu Ser Leu Lys Val Val Leu Thr Arg Ala Phe Lys 
    290                 295                 300                 


Asp Glu Met Gln Pro Arg Arg Gln Lys Asp Asn Cys Asn Thr Val Thr 
305                 310                 315                 320 


Val Glu Thr Val Val 
                325 


<210>  2638
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  2638

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2639
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  2639

Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Asp Ala Cys Glu Glu Pro Pro Thr Phe Glu Ala Met Glu Leu Ile Gly 
        35                  40                  45              


Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys 
    50                  55                  60                  


Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Thr His Thr Ile Cys 
65                  70                  75                  80  


Asp Arg Asn His Thr Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg 
                85                  90                  95      


Glu Thr Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
            100                 105                 110         


Ala Asn Gly Thr Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
        115                 120                 125             


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
    130                 135                 140                 


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
145                 150                 155                 160 


Leu Cys Thr Pro Pro Pro Lys Ile Lys Asn Gly Lys His Thr Phe Ser 
                165                 170                 175     


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Thr Tyr Ser Cys Asp 
            180                 185                 190         


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Thr Ile 
        195                 200                 205             


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
    210                 215                 220                 


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
225                 230                 235                 240 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Thr Val Met Phe Glu Cys 
                245                 250                 255     


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Thr Ile Val Cys Asp Ser 
            260                 265                 270         


Asn Ser Thr Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Val Leu Pro 
        275                 280                 285             


Pro Ser Ser Thr Lys Pro Pro Ala Leu Ser His Ser Val Ser Thr Ser 
    290                 295                 300                 


Ser Thr Thr Lys Ser Pro Ala Ser Ser Ala Ser Gly Pro Arg Pro Thr 
305                 310                 315                 320 


Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro Glu Glu 
                325                 330                 335     


Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val Ile Val Ile 
            340                 345                 350         


Ala Ile Val Val Gly Val Ala Val Ile Cys Val Val Pro Tyr Arg Tyr 
        355                 360                 365             


Leu Gln Arg Arg Lys Lys Lys Gly Thr Tyr Leu Thr Asp Glu Thr His 
    370                 375                 380                 


Arg Glu Val Lys Phe Thr Ser Leu 
385                 390         


<210>  2640
<211>  769
<212>  PRT
<213>  Homo sapiens

<400>  2640

Met Arg Leu Leu Arg Arg Trp Ala Phe Ala Ala Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Pro Thr Pro Gly Leu Gly Thr Gln Gly Pro Ala Gly Ala Leu Arg 
            20                  25                  30          


Trp Gly Gly Leu Pro Gln Leu Gly Gly Pro Gly Ala Pro Glu Val Thr 
        35                  40                  45              


Glu Pro Ser Arg Leu Val Arg Glu Ser Ser Gly Gly Glu Val Arg Lys 
    50                  55                  60                  


Gln Gln Leu Asp Thr Arg Val Arg Gln Glu Pro Pro Gly Gly Pro Pro 
65                  70                  75                  80  


Val His Leu Ala Gln Val Ser Phe Val Ile Pro Ala Phe Asn Ser Asn 
                85                  90                  95      


Phe Thr Leu Asp Leu Glu Leu Asn His His Leu Leu Ser Ser Gln Tyr 
            100                 105                 110         


Val Glu Arg His Phe Ser Arg Glu Gly Thr Thr Gln His Ser Thr Gly 
        115                 120                 125             


Ala Gly Asp His Cys Tyr Tyr Gln Gly Lys Leu Arg Gly Asn Pro His 
    130                 135                 140                 


Ser Phe Ala Ala Leu Ser Thr Cys Gln Gly Leu His Gly Val Phe Ser 
145                 150                 155                 160 


Asp Gly Asn Leu Thr Tyr Ile Val Glu Pro Gln Glu Val Ala Gly Pro 
                165                 170                 175     


Trp Gly Ala Pro Gln Gly Pro Leu Pro His Leu Ile Tyr Arg Thr Pro 
            180                 185                 190         


Leu Leu Pro Asp Pro Leu Gly Cys Arg Glu Pro Gly Cys Leu Phe Ala 
        195                 200                 205             


Val Pro Ala Gln Ser Ala Pro Pro Asn Arg Pro Arg Leu Arg Arg Lys 
    210                 215                 220                 


Arg Gln Val Arg Arg Gly His Pro Thr Val His Ser Glu Thr Lys Tyr 
225                 230                 235                 240 


Val Glu Leu Ile Val Ile Asn Asp His Gln Leu Phe Glu Gln Met Arg 
                245                 250                 255     


Gln Ser Val Val Leu Thr Ser Asn Phe Ala Lys Ser Val Val Asn Leu 
            260                 265                 270         


Ala Asp Val Ile Tyr Lys Glu Gln Leu Asn Thr Arg Ile Val Leu Val 
        275                 280                 285             


Ala Met Glu Thr Trp Ala Asp Gly Asp Lys Ile Gln Val Gln Asp Asp 
    290                 295                 300                 


Leu Leu Glu Thr Leu Ala Arg Leu Met Val Tyr Arg Arg Glu Gly Leu 
305                 310                 315                 320 


Pro Glu Pro Ser Asp Ala Thr His Leu Phe Ser Gly Arg Thr Phe Gln 
                325                 330                 335     


Ser Thr Ser Ser Gly Ala Ala Tyr Val Gly Gly Ile Cys Ser Leu Ser 
            340                 345                 350         


His Gly Gly Gly Val Asn Glu Tyr Gly Asn Met Gly Ala Met Ala Val 
        355                 360                 365             


Thr Leu Ala Gln Thr Leu Gly Gln Asn Leu Gly Met Met Trp Asn Lys 
    370                 375                 380                 


His Arg Ser Ser Ala Gly Asp Cys Lys Cys Pro Asp Ile Trp Leu Gly 
385                 390                 395                 400 


Cys Ile Met Glu Asp Thr Gly Phe Tyr Leu Pro Arg Lys Phe Ser Arg 
                405                 410                 415     


Cys Ser Ile Asp Glu Tyr Asn Gln Phe Leu Gln Glu Gly Gly Gly Ser 
            420                 425                 430         


Cys Leu Phe Asn Lys Pro Leu Lys Leu Leu Asp Pro Pro Glu Cys Gly 
        435                 440                 445             


Asn Gly Phe Val Glu Ala Gly Glu Glu Cys Asp Cys Gly Ser Val Gln 
    450                 455                 460                 


Glu Cys Ser Arg Ala Gly Gly Asn Cys Cys Lys Lys Cys Thr Leu Thr 
465                 470                 475                 480 


His Asp Ala Met Cys Ser Asp Gly Leu Cys Cys Arg Arg Cys Lys Tyr 
                485                 490                 495     


Glu Pro Arg Gly Val Ser Cys Arg Glu Ala Val Asn Glu Cys Asp Ile 
            500                 505                 510         


Ala Glu Thr Cys Thr Gly Asp Ser Ser Gln Cys Pro Pro Asn Leu His 
        515                 520                 525             


Lys Leu Asp Gly Tyr Tyr Cys Asp His Glu Gln Gly Arg Cys Tyr Gly 
    530                 535                 540                 


Gly Arg Cys Lys Thr Arg Asp Arg Gln Cys Gln Val Leu Trp Gly His 
545                 550                 555                 560 


Ala Ala Ala Asp Arg Phe Cys Tyr Glu Lys Leu Asn Val Glu Gly Thr 
                565                 570                 575     


Glu Arg Gly Ser Cys Gly Arg Lys Gly Ser Gly Trp Val Gln Cys Ser 
            580                 585                 590         


Lys Gln Asp Val Leu Cys Gly Phe Leu Leu Cys Val Asn Ile Ser Gly 
        595                 600                 605             


Ala Pro Arg Leu Gly Asp Leu Val Gly Asp Ile Ser Ser Val Thr Phe 
    610                 615                 620                 


Tyr His Gln Gly Lys Glu Leu Asp Cys Arg Gly Gly His Val Gln Leu 
625                 630                 635                 640 


Ala Asp Gly Ser Asp Leu Ser Tyr Val Glu Asp Gly Thr Ala Cys Gly 
                645                 650                 655     


Pro Asn Met Leu Cys Leu Asp His Arg Cys Leu Pro Ala Ser Ala Phe 
            660                 665                 670         


Asn Phe Ser Thr Cys Pro Gly Ser Gly Glu Arg Arg Ile Cys Ser His 
        675                 680                 685             


His Gly Val Cys Ser Asn Glu Gly Lys Cys Ile Cys Gln Pro Asp Trp 
    690                 695                 700                 


Thr Gly Lys Asp Cys Ser Ile His Asn Pro Leu Pro Thr Ser Pro Pro 
705                 710                 715                 720 


Thr Gly Glu Thr Glu Arg Tyr Lys Gly Pro Ser Gly Thr Asn Ile Ile 
                725                 730                 735     


Ile Gly Ser Ile Ala Gly Ala Val Leu Val Ala Ala Ile Val Leu Gly 
            740                 745                 750         


Gly Thr Gly Trp Gly Phe Lys Asn Ile Arg Arg Gly Arg Ser Gly Gly 
        755                 760                 765             


Ala 
    


<210>  2641
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  2641

Met Glu Leu Gln Pro Pro Glu Ala Ser Ile Ala Val Val Ser Ile Pro 
1               5                   10                  15      


Arg Gln Leu Pro Gly Ser His Ser Glu Ala Gly Val Gln Gly Leu Ser 
            20                  25                  30          


Ala Gly Asp Asp Ser Glu Leu Gly Ser His Cys Val Ala Gln Thr Gly 
        35                  40                  45              


Leu Glu Leu Leu Ala Ser Gly Asp Pro Leu Pro Ser Ala Ser Gln Asn 
    50                  55                  60                  


Ala Glu Met Ile Glu Thr Gly Ser Asp Cys Val Thr Gln Ala Gly Leu 
65                  70                  75                  80  


Gln Leu Leu Ala Ser Ser Asp Pro Pro Ala Leu Ala Ser Lys Asn Ala 
                85                  90                  95      


Glu Val Thr Gly Thr Met Ser Gln Asp Thr Glu Val Asp Met Lys Glu 
            100                 105                 110         


Val Glu Leu Asn Glu Leu Glu Pro Glu Lys Gln Pro Met Asn Ala Ala 
        115                 120                 125             


Ser Gly Ala Ala Met Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu Val 
    130                 135                 140                 


Lys Ile Lys Val Ala Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala Lys 
145                 150                 155                 160 


Phe Thr Gly Leu Ser Lys Glu Glu Leu Leu Lys Val Ala Gly Ser Pro 
                165                 170                 175     


Gly Trp Val Arg Thr Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly 
            180                 185                 190         


Trp Leu Gly Met Leu Ala Gly Ala Val Val Ile Ile Val Arg Ala Pro 
        195                 200                 205             


Arg Cys Arg Glu Leu Pro Ala Gln Lys Trp Trp His Thr Gly Ala Leu 
    210                 215                 220                 


Tyr Arg Ile Gly Asp Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn 
225                 230                 235                 240 


Leu Ala Gly Leu Lys Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val 
                245                 250                 255     


Lys Gly Leu Val Leu Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val 
            260                 265                 270         


Ala Gln Thr Asp Leu Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu 
        275                 280                 285             


Asp Phe Asp Ser Leu Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg Val 
    290                 295                 300                 


Ile Leu Asp Leu Thr Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe Ser 
305                 310                 315                 320 


Thr Gln Val Asp Thr Val Ala Thr Lys Val Lys Asp Ala Leu Glu Phe 
                325                 330                 335     


Trp Leu Gln Ala Gly Val Asp Gly Phe Gln Val Arg Asp Ile Glu Asn 
            340                 345                 350         


Leu Lys Asp Ala Ser Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys 
        355                 360                 365             


Gly Phe Ser Glu Asp Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp 
    370                 375                 380                 


Leu Gln Gln Ile Leu Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu 
385                 390                 395                 400 


Thr Ser Ser Tyr Leu Ser Asp Ser Gly Ser Thr Gly Glu His Thr Lys 
                405                 410                 415     


Ser Leu Val Thr Gln Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser 
            420                 425                 430         


Trp Ser Leu Ser Gln Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln 
        435                 440                 445             


Leu Leu Arg Leu Tyr Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro 
    450                 455                 460                 


Val Phe Ser Tyr Gly Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu Pro 
465                 470                 475                 480 


Gly Gln Pro Met Glu Ala Pro Val Met Leu Trp Asp Glu Ser Ser Phe 
                485                 490                 495     


Pro Asp Ile Pro Gly Ala Val Ser Ala Asn Met Thr Val Lys Gly Gln 
            500                 505                 510         


Ser Glu Asp Pro Gly Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser Asp 
        515                 520                 525             


Gln Arg Ser Lys Glu Arg Ser Leu Leu His Gly Asp Phe His Ala Phe 
    530                 535                 540                 


Ser Ala Gly Pro Gly Leu Phe Ser Tyr Ile Arg His Trp Asp Gln Asn 
545                 550                 555                 560 


Glu Arg Phe Leu Val Val Leu Asn Phe Gly Asp Val Gly Leu Ser Ala 
                565                 570                 575     


Gly Leu Gln Ala Ser Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala Lys 
            580                 585                 590         


Ala Asp Leu Leu Leu Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser Pro 
        595                 600                 605             


Leu Glu Leu Glu Arg Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu 
    610                 615                 620                 


Arg Phe Pro Tyr Ala Ala 
625                 630 


<210>  2642
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  2642

Met Leu Lys Lys Gln Ser Ala Gly Leu Val Leu Trp Gly Ala Ile Leu 
1               5                   10                  15      


Phe Val Ala Trp Asn Ala Leu Leu Leu Leu Phe Phe Trp Thr Arg Pro 
            20                  25                  30          


Ala Pro Gly Arg Pro Pro Ser Val Ser Ala Leu Asp Gly Asp Pro Ala 
        35                  40                  45              


Ser Leu Thr Arg Glu Val Ile Arg Leu Ala Gln Asp Ala Glu Val Glu 
    50                  55                  60                  


Leu Glu Arg Gln Arg Gly Leu Leu Gln Gln Ile Gly Asp Ala Leu Ser 
65                  70                  75                  80  


Ser Gln Arg Gly Arg Val Pro Thr Ala Ala Pro Pro Ala Gln Pro Arg 
                85                  90                  95      


Val Pro Val Thr Pro Ala Pro Ala Val Ile Pro Ile Leu Val Ile Ala 
            100                 105                 110         


Cys Asp Arg Ser Thr Val Arg Arg Cys Leu Asp Lys Leu Leu His Tyr 
        115                 120                 125             


Arg Pro Ser Ala Glu Leu Phe Pro Ile Ile Val Ser Gln Asp Cys Gly 
    130                 135                 140                 


His Glu Glu Thr Ala Gln Ala Ile Ala Ser Tyr Gly Ser Ala Val Thr 
145                 150                 155                 160 


His Ile Arg Gln Pro Asp Leu Ser Ser Ile Ala Val Pro Pro Asp His 
                165                 170                 175     


Arg Lys Phe Gln Gly Tyr Tyr Lys Ile Ala Arg His Tyr Arg Trp Ala 
            180                 185                 190         


Leu Gly Gln Val Phe Arg Gln Phe Arg Phe Pro Ala Ala Val Val Val 
        195                 200                 205             


Glu Asp Asp Leu Glu Val Ala Pro Asp Phe Phe Glu Tyr Phe Arg Ala 
    210                 215                 220                 


Thr Tyr Pro Leu Leu Lys Ala Asp Pro Ser Leu Trp Cys Val Ser Ala 
225                 230                 235                 240 


Trp Asn Asp Asn Gly Lys Glu Gln Met Val Asp Ala Ser Arg Pro Glu 
                245                 250                 255     


Leu Leu Tyr Arg Thr Asp Phe Phe Pro Gly Leu Gly Trp Leu Leu Leu 
            260                 265                 270         


Ala Glu Leu Trp Ala Glu Leu Glu Pro Lys Trp Pro Lys Ala Phe Trp 
        275                 280                 285             


Asp Asp Trp Met Arg Arg Pro Glu Gln Arg Gln Gly Arg Ala Cys Ile 
    290                 295                 300                 


Arg Pro Glu Ile Ser Arg Thr Met Thr Phe Gly Arg Lys Gly Val Ser 
305                 310                 315                 320 


His Gly Gln Phe Phe Asp Gln His Leu Lys Phe Ile Lys Leu Asn Gln 
                325                 330                 335     


Gln Phe Val His Phe Thr Gln Leu Asp Leu Ser Tyr Leu Gln Arg Glu 
            340                 345                 350         


Ala Tyr Asp Arg Asp Phe Leu Ala Arg Val Tyr Gly Ala Pro Gln Leu 
        355                 360                 365             


Gln Val Glu Lys Val Arg Thr Asn Asp Arg Lys Glu Leu Gly Glu Val 
    370                 375                 380                 


Arg Val Gln Tyr Thr Gly Arg Asp Ser Phe Lys Ala Phe Ala Lys Ala 
385                 390                 395                 400 


Leu Gly Val Met Asp Asp Leu Lys Ser Gly Val Pro Arg Ala Gly Tyr 
                405                 410                 415     


Arg Gly Ile Val Thr Phe Gln Phe Arg Gly Arg Arg Val His Leu Ala 
            420                 425                 430         


Pro Pro Leu Thr Trp Glu Gly Tyr Asp Pro Ser Trp Asn 
        435                 440                 445 


<210>  2643
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  2643

Met Arg Phe Arg Ile Tyr Lys Arg Lys Val Leu Ile Leu Thr Leu Val 
1               5                   10                  15      


Val Ala Ala Cys Gly Phe Val Leu Trp Ser Ser Asn Gly Arg Gln Arg 
            20                  25                  30          


Lys Asn Glu Ala Leu Ala Pro Pro Leu Leu Asp Ala Glu Pro Ala Arg 
        35                  40                  45              


Gly Ala Gly Gly Arg Gly Gly Asp His Pro Ser Val Ala Val Gly Ile 
    50                  55                  60                  


Arg Arg Val Ser Asn Val Ser Ala Ala Ser Leu Val Pro Ala Val Pro 
65                  70                  75                  80  


Gln Pro Glu Ala Asp Asn Leu Thr Leu Arg Tyr Arg Ser Leu Val Tyr 
                85                  90                  95      


Gln Leu Asn Phe Asp Gln Thr Leu Arg Asn Val Asp Lys Ala Gly Thr 
            100                 105                 110         


Trp Ala Pro Arg Glu Leu Val Leu Val Val Gln Val His Asn Arg Pro 
        115                 120                 125             


Glu Tyr Leu Arg Leu Leu Leu Asp Ser Leu Arg Lys Ala Gln Gly Ile 
    130                 135                 140                 


Asp Asn Val Leu Val Ile Phe Ser His Asp Phe Trp Ser Thr Glu Ile 
145                 150                 155                 160 


Asn Gln Leu Ile Ala Gly Val Asn Phe Cys Pro Val Leu Gln Val Phe 
                165                 170                 175     


Phe Pro Phe Ser Ile Gln Leu Tyr Pro Asn Glu Phe Pro Gly Ser Asp 
            180                 185                 190         


Pro Arg Asp Cys Pro Arg Asp Leu Pro Lys Asn Ala Ala Leu Lys Leu 
        195                 200                 205             


Gly Cys Ile Asn Ala Glu Tyr Pro Asp Ser Phe Gly His Tyr Arg Glu 
    210                 215                 220                 


Ala Lys Phe Ser Gln Thr Lys His His Trp Trp Trp Lys Leu His Phe 
225                 230                 235                 240 


Val Trp Glu Arg Val Lys Ile Leu Arg Asp Tyr Ala Gly Leu Ile Leu 
                245                 250                 255     


Phe Leu Glu Glu Asp His Tyr Leu Ala Pro Asp Phe Tyr His Val Phe 
            260                 265                 270         


Lys Lys Met Trp Lys Leu Lys Gln Gln Glu Cys Pro Glu Cys Asp Val 
        275                 280                 285             


Leu Ser Leu Gly Thr Tyr Ser Ala Ser Arg Ser Phe Tyr Gly Met Ala 
    290                 295                 300                 


Asp Lys Val Asp Val Lys Thr Trp Lys Ser Thr Glu His Asn Met Gly 
305                 310                 315                 320 


Leu Ala Leu Thr Arg Asn Ala Tyr Gln Lys Leu Ile Glu Cys Thr Asp 
                325                 330                 335     


Thr Phe Cys Thr Tyr Asp Asp Tyr Asn Trp Asp Trp Thr Leu Gln Tyr 
            340                 345                 350         


Leu Thr Val Ser Cys Leu Pro Lys Phe Trp Lys Val Leu Val Pro Gln 
        355                 360                 365             


Ile Pro Arg Ile Phe His Ala Gly Asp Cys Gly Met His His Lys Lys 
    370                 375                 380                 


Thr Cys Arg Pro Ser Thr Gln Ser Ala Gln Ile Glu Ser Leu Leu Asn 
385                 390                 395                 400 


Asn Asn Lys Gln Tyr Met Phe Pro Glu Thr Leu Thr Ile Ser Glu Lys 
                405                 410                 415     


Phe Thr Val Val Ala Ile Ser Pro Pro Arg Lys Asn Gly Gly Trp Gly 
            420                 425                 430         


Asp Ile Arg Asp His Glu Leu Cys Lys Ser Tyr Arg Arg Leu Gln 
        435                 440                 445         


<210>  2644
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  2644

Met Lys Met Arg Arg Tyr Lys Leu Phe Leu Met Phe Cys Met Ala Gly 
1               5                   10                  15      


Leu Cys Leu Ile Ser Phe Leu His Phe Phe Lys Thr Leu Ser Tyr Val 
            20                  25                  30          


Thr Phe Pro Arg Glu Leu Ala Ser Leu Ser Pro Asn Leu Val Ser Ser 
        35                  40                  45              


Phe Phe Trp Asn Asn Ala Pro Val Thr Pro Gln Ala Ser Pro Glu Pro 
    50                  55                  60                  


Gly Gly Pro Asp Leu Leu Arg Thr Pro Leu Tyr Ser His Ser Pro Leu 
65                  70                  75                  80  


Leu Gln Pro Leu Pro Pro Ser Lys Ala Ala Glu Glu Leu His Arg Val 
                85                  90                  95      


Asp Leu Val Leu Pro Glu Asp Thr Thr Glu Tyr Phe Val Arg Thr Lys 
            100                 105                 110         


Ala Gly Gly Val Cys Phe Lys Pro Gly Thr Lys Met Leu Glu Arg Pro 
        115                 120                 125             


Pro Pro Gly Arg Pro Glu Glu Lys Pro Glu Gly Ala Asn Gly Ser Ser 
    130                 135                 140                 


Ala Arg Arg Pro Pro Arg Tyr Leu Leu Ser Ala Arg Glu Arg Thr Gly 
145                 150                 155                 160 


Gly Arg Gly Ala Arg Arg Lys Trp Val Glu Cys Val Cys Leu Pro Gly 
                165                 170                 175     


Trp His Gly Pro Ser Cys Gly Val Pro Thr Val Val Gln Tyr Ser Asn 
            180                 185                 190         


Leu Pro Thr Lys Glu Arg Leu Val Pro Arg Glu Val Pro Arg Arg Val 
        195                 200                 205             


Ile Asn Ala Ile Asn Val Asn His Glu Phe Asp Leu Leu Asp Val Arg 
    210                 215                 220                 


Phe His Glu Leu Gly Asp Val Val Asp Ala Phe Val Val Cys Glu Ser 
225                 230                 235                 240 


Asn Phe Thr Ala Tyr Gly Glu Pro Arg Pro Leu Lys Phe Arg Glu Met 
                245                 250                 255     


Leu Thr Asn Gly Thr Phe Glu Tyr Ile Arg His Lys Val Leu Tyr Val 
            260                 265                 270         


Phe Leu Asp His Phe Pro Pro Gly Gly Arg Gln Asp Gly Trp Ile Ala 
        275                 280                 285             


Asp Asp Tyr Leu Arg Thr Phe Leu Thr Gln Asp Gly Val Ser Arg Leu 
    290                 295                 300                 


Arg Asn Leu Arg Pro Asp Asp Val Phe Ile Ile Asp Asp Ala Asp Glu 
305                 310                 315                 320 


Ile Pro Ala Arg Asp Gly Val Leu Phe Leu Lys Leu Tyr Asp Gly Trp 
                325                 330                 335     


Thr Glu Pro Phe Ala Phe His Met Arg Lys Ser Leu Tyr Gly Phe Phe 
            340                 345                 350         


Trp Lys Gln Pro Gly Thr Leu Glu Val Val Ser Gly Cys Thr Val Asp 
        355                 360                 365             


Met Leu Gln Ala Val Tyr Gly Leu Asp Gly Ile Arg Leu Arg Arg Arg 
    370                 375                 380                 


Gln Tyr Tyr Thr Met Pro Asn Phe Arg Gln Tyr Glu Asn Arg Thr Gly 
385                 390                 395                 400 


His Ile Leu Val Gln Trp Ser Leu Gly Ser Pro Leu His Phe Ala Gly 
                405                 410                 415     


Trp His Cys Ser Trp Cys Phe Thr Pro Glu Gly Ile Tyr Phe Lys Leu 
            420                 425                 430         


Val Ser Ala Gln Asn Gly Asp Phe Pro Arg Trp Gly Asp Tyr Glu Asp 
        435                 440                 445             


Lys Arg Asp Leu Asn Tyr Ile Arg Gly Leu Ile Arg Thr Gly Gly Trp 
    450                 455                 460                 


Phe Asp Gly Thr Gln Gln Glu Tyr Pro Pro Ala Asp Pro Ser Glu His 
465                 470                 475                 480 


Met Tyr Ala Pro Lys Tyr Leu Leu Lys Asn Tyr Asp Arg Phe His Tyr 
                485                 490                 495     


Leu Leu Asp Asn Pro Tyr Gln Glu Pro Arg Ser Thr Ala Ala Gly Gly 
            500                 505                 510         


Trp Arg His Arg Gly Pro Glu Gly Arg Pro Pro Ala Arg Gly Lys Leu 
        515                 520                 525             


Asp Glu Ala Glu Val 
    530             


<210>  2645
<211>  741
<212>  PRT
<213>  Homo sapiens

<400>  2645

Met Ala Leu Phe Thr Pro Trp Lys Leu Ser Ser Gln Lys Leu Gly Phe 
1               5                   10                  15      


Phe Leu Val Thr Phe Gly Phe Ile Trp Gly Met Met Leu Leu His Phe 
            20                  25                  30          


Thr Ile Gln Gln Arg Thr Gln Pro Glu Ser Ser Ser Met Leu Arg Glu 
        35                  40                  45              


Gln Ile Leu Asp Leu Ser Lys Arg Tyr Ile Lys Ala Leu Ala Glu Glu 
    50                  55                  60                  


Asn Arg Asn Val Val Asp Gly Pro Tyr Ala Gly Val Met Thr Ala Tyr 
65                  70                  75                  80  


Asp Leu Lys Lys Thr Leu Ala Val Leu Leu Asp Asn Ile Leu Gln Arg 
                85                  90                  95      


Ile Gly Lys Leu Glu Ser Lys Val Asp Asn Leu Val Val Asn Gly Thr 
            100                 105                 110         


Gly Thr Asn Ser Thr Asn Ser Thr Thr Ala Val Pro Ser Leu Val Ala 
        115                 120                 125             


Leu Glu Lys Ile Asn Val Ala Asp Ile Ile Asn Gly Ala Gln Glu Lys 
    130                 135                 140                 


Cys Val Leu Pro Pro Met Asp Gly Tyr Pro His Cys Glu Gly Lys Ile 
145                 150                 155                 160 


Lys Trp Met Lys Asp Met Trp Arg Ser Asp Pro Cys Tyr Ala Asp Tyr 
                165                 170                 175     


Gly Val Asp Gly Ser Thr Cys Ser Phe Phe Ile Tyr Leu Ser Glu Val 
            180                 185                 190         


Glu Asn Trp Cys Pro His Leu Pro Trp Arg Ala Lys Asn Pro Tyr Glu 
        195                 200                 205             


Glu Ala Asp His Asn Ser Leu Ala Glu Ile Arg Thr Asp Phe Asn Ile 
    210                 215                 220                 


Leu Tyr Ser Met Met Lys Lys His Glu Glu Phe Arg Trp Met Arg Leu 
225                 230                 235                 240 


Arg Ile Arg Arg Met Ala Asp Ala Trp Ile Gln Ala Ile Lys Ser Leu 
                245                 250                 255     


Ala Glu Lys Gln Asn Leu Glu Lys Arg Lys Arg Lys Lys Val Leu Val 
            260                 265                 270         


His Leu Gly Leu Leu Thr Lys Glu Ser Gly Phe Lys Ile Ala Glu Thr 
        275                 280                 285             


Ala Phe Ser Gly Gly Pro Leu Gly Glu Leu Val Gln Trp Ser Asp Leu 
    290                 295                 300                 


Ile Thr Ser Leu Tyr Leu Leu Gly His Asp Ile Arg Ile Ser Ala Ser 
305                 310                 315                 320 


Leu Ala Glu Leu Lys Glu Ile Met Lys Lys Val Val Gly Asn Arg Ser 
                325                 330                 335     


Gly Cys Pro Thr Val Gly Asp Arg Ile Val Glu Leu Ile Tyr Ile Asp 
            340                 345                 350         


Ile Val Gly Leu Ala Gln Phe Lys Lys Thr Leu Gly Pro Ser Trp Val 
        355                 360                 365             


His Tyr Gln Cys Met Leu Arg Val Leu Asp Ser Phe Gly Thr Glu Pro 
    370                 375                 380                 


Glu Phe Asn His Ala Asn Tyr Ala Gln Ser Lys Gly His Lys Thr Pro 
385                 390                 395                 400 


Trp Gly Lys Trp Asn Leu Asn Pro Gln Gln Phe Tyr Thr Met Phe Pro 
                405                 410                 415     


His Thr Pro Asp Asn Ser Phe Leu Gly Phe Val Val Glu Gln His Leu 
            420                 425                 430         


Asn Ser Ser Asp Ile His His Ile Asn Glu Ile Lys Arg Gln Asn Gln 
        435                 440                 445             


Ser Leu Val Tyr Gly Lys Val Asp Ser Phe Trp Lys Asn Lys Lys Ile 
    450                 455                 460                 


Tyr Leu Asp Ile Ile His Thr Tyr Met Glu Val His Ala Thr Val Tyr 
465                 470                 475                 480 


Gly Ser Ser Thr Lys Asn Ile Pro Ser Tyr Val Lys Asn His Gly Ile 
                485                 490                 495     


Leu Ser Gly Arg Asp Leu Gln Phe Leu Leu Arg Glu Thr Lys Leu Phe 
            500                 505                 510         


Val Gly Leu Gly Phe Pro Tyr Glu Gly Pro Ala Pro Leu Glu Ala Ile 
        515                 520                 525             


Ala Asn Gly Cys Ala Phe Leu Asn Pro Lys Phe Asn Pro Pro Lys Ser 
    530                 535                 540                 


Ser Lys Asn Thr Asp Phe Phe Ile Gly Lys Pro Thr Leu Arg Glu Leu 
545                 550                 555                 560 


Thr Ser Gln His Pro Tyr Ala Glu Val Phe Ile Gly Arg Pro His Val 
                565                 570                 575     


Trp Thr Val Asp Leu Asn Asn Gln Glu Glu Val Glu Asp Ala Val Lys 
            580                 585                 590         


Ala Ile Leu Asn Gln Lys Ile Glu Pro Tyr Met Pro Tyr Glu Phe Thr 
        595                 600                 605             


Cys Glu Gly Met Leu Gln Arg Ile Asn Ala Phe Ile Glu Lys Gln Asp 
    610                 615                 620                 


Phe Cys His Gly Gln Val Met Trp Pro Pro Leu Ser Ala Leu Gln Val 
625                 630                 635                 640 


Lys Leu Ala Glu Pro Gly Gln Ser Cys Lys Gln Val Cys Gln Glu Ser 
                645                 650                 655     


Gln Leu Ile Cys Glu Pro Ser Phe Phe Gln His Leu Asn Lys Asp Lys 
            660                 665                 670         


Asp Met Leu Lys Tyr Lys Val Thr Cys Gln Ser Ser Glu Leu Ala Lys 
        675                 680                 685             


Asp Ile Leu Val Pro Ser Phe Asp Pro Lys Asn Lys His Cys Val Phe 
    690                 695                 700                 


Gln Gly Asp Leu Leu Leu Phe Ser Cys Ala Gly Ala His Pro Arg His 
705                 710                 715                 720 


Gln Arg Val Cys Pro Cys Arg Asp Phe Ile Lys Gly Gln Val Ala Leu 
                725                 730                 735     


Cys Lys Asp Cys Leu 
            740     


<210>  2646
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  2646

Met Ala Gly Asn Ser Ile Leu Leu Ala Ala Val Ser Ile Leu Ser Ala 
1               5                   10                  15      


Cys Gln Gln Ser Tyr Phe Ala Leu Gln Val Gly Lys Ala Arg Leu Lys 
            20                  25                  30          


Tyr Lys Val Thr Pro Pro Ala Val Thr Gly Ser Pro Glu Phe Glu Arg 
        35                  40                  45              


Val Phe Arg Ala Gln Gln Asn Cys Val Glu Phe Tyr Pro Ile Phe Ile 
    50                  55                  60                  


Ile Thr Leu Trp Met Ala Gly Trp Tyr Phe Asn Gln Val Phe Ala Thr 
65                  70                  75                  80  


Cys Leu Gly Leu Val Tyr Ile Tyr Gly Arg His Leu Tyr Phe Trp Gly 
                85                  90                  95      


Tyr Ser Glu Ala Ala Lys Lys Arg Ile Thr Gly Phe Arg Leu Ser Leu 
            100                 105                 110         


Gly Ile Leu Ala Leu Leu Thr Leu Leu Gly Ala Leu Gly Ile Ala Asn 
        115                 120                 125             


Ser Phe Leu Asp Glu Tyr Leu Asp Leu Asn Ile Ala Lys Lys Leu Arg 
    130                 135                 140                 


Arg Gln Phe 
145         


<210>  2647
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  2647

Met Ala Arg Gly Ala Ala Leu Ala Leu Leu Leu Phe Gly Leu Leu Gly 
1               5                   10                  15      


Val Leu Val Ala Ala Pro Asp Gly Gly Phe Asp Leu Ser Asp Ala Leu 
            20                  25                  30          


Pro Asp Asn Glu Asn Lys Lys Pro Thr Ala Ile Pro Lys Lys Pro Ser 
        35                  40                  45              


Ala Gly Asp Asp Phe Asp Leu Gly Asp Ala Val Val Asp Gly Glu Asn 
    50                  55                  60                  


Asp Asp Pro Arg Pro Pro Asn Pro Pro Lys Pro Met Pro Asn Pro Asn 
65                  70                  75                  80  


Pro Asn His Pro Ser Ser Ser Gly Ser Phe Ser Asp Ala Asp Leu Ala 
                85                  90                  95      


Asp Gly Val Ser Gly Gly Glu Gly Lys Gly Gly Ser Asp Gly Gly Gly 
            100                 105                 110         


Ser His Arg Lys Glu Gly Glu Glu Ala Asp Ala Pro Gly Val Ile Pro 
        115                 120                 125             


Gly Ile Val Gly Ala Val Val Val Ala Val Ala Gly Ala Ile Ser Ser 
    130                 135                 140                 


Phe Ile Ala Tyr Gln Lys Lys Lys Leu Cys Phe Lys Glu Asn Ala Glu 
145                 150                 155                 160 


Gln Gly Glu Val Asp Met Glu Ser His Arg Asn Ala Asn Ala Glu Pro 
                165                 170                 175     


Ala Val Gln Arg Thr Leu Leu Glu Lys 
            180                 185 


<210>  2648
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  2648

Met Lys Lys Ser Gly Val Leu Phe Leu Leu Gly Ile Ile Leu Leu Val 
1               5                   10                  15      


Leu Ile Gly Val Gln Gly Thr Pro Val Val Arg Lys Gly Arg Cys Ser 
            20                  25                  30          


Cys Ile Ser Thr Asn Gln Gly Thr Ile His Leu Gln Ser Leu Lys Asp 
        35                  40                  45              


Leu Lys Gln Phe Ala Pro Ser Pro Ser Cys Glu Lys Ile Glu Ile Ile 
    50                  55                  60                  


Ala Thr Leu Lys Asn Gly Val Gln Thr Cys Leu Asn Pro Asp Ser Ala 
65                  70                  75                  80  


Asp Val Lys Glu Leu Ile Lys Lys Trp Glu Lys Gln Val Ser Gln Lys 
                85                  90                  95      


Lys Lys Gln Lys Asn Gly Lys Lys His Gln Lys Lys Lys Val Leu Lys 
            100                 105                 110         


Val Arg Lys Ser Gln Arg Ser Arg Gln Lys Lys Thr Thr 
        115                 120                 125 


<210>  2649
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  2649

Met Val Ser Arg Lys Ala Val Ala Ala Leu Leu Val Val His Val Ala 
1               5                   10                  15      


Ala Met Leu Ala Ser Gln Thr Glu Ala Phe Val Pro Ile Phe Thr Tyr 
            20                  25                  30          


Gly Glu Leu Gln Arg Met Gln Glu Lys Glu Arg Asn Lys Gly Gln Lys 
        35                  40                  45              


Lys Ser Leu Ser Val Trp Gln Arg Ser Gly Glu Glu Gly Pro Val Asp 
    50                  55                  60                  


Pro Ala Glu Pro Ile Arg Glu Glu Glu Asn Glu Met Ile Lys Leu Thr 
65                  70                  75                  80  


Ala Pro Leu Glu Ile Gly Met Arg Met Asn Ser Arg Gln Leu Glu Lys 
                85                  90                  95      


Tyr Pro Ala Thr Leu Glu Gly Leu Leu Ser Glu Met Leu Pro Gln His 
            100                 105                 110         


Ala Ala Lys 
        115 


<210>  2650
<211>  1603
<212>  PRT
<213>  Homo sapiens

<400>  2650

Met Lys Asp Ser Asn Arg Cys Cys Cys Gly Gln Phe Thr Asn Gln His 
1               5                   10                  15      


Ile Pro Pro Leu Pro Ser Ala Thr Pro Ser Lys Asn Glu Glu Glu Ser 
            20                  25                  30          


Lys Gln Val Glu Thr Gln Pro Glu Lys Trp Ser Val Ala Lys His Thr 
        35                  40                  45              


Gln Ser Tyr Pro Thr Asp Ser Tyr Gly Val Leu Glu Phe Gln Gly Gly 
    50                  55                  60                  


Gly Tyr Ser Asn Lys Ala Met Tyr Ile Arg Val Ser Tyr Asp Thr Lys 
65                  70                  75                  80  


Pro Asp Ser Leu Leu His Leu Met Val Lys Asp Trp Gln Leu Glu Leu 
                85                  90                  95      


Pro Lys Leu Leu Ile Ser Val His Gly Gly Leu Gln Asn Phe Glu Met 
            100                 105                 110         


Gln Pro Lys Leu Lys Gln Val Phe Gly Lys Gly Leu Ile Lys Ala Ala 
        115                 120                 125             


Met Thr Thr Gly Ala Trp Ile Phe Thr Gly Gly Val Ser Thr Gly Val 
    130                 135                 140                 


Ile Ser His Val Gly Asp Ala Leu Lys Asp His Ser Ser Lys Ser Arg 
145                 150                 155                 160 


Gly Arg Val Cys Ala Ile Gly Ile Ala Pro Trp Gly Ile Val Glu Asn 
                165                 170                 175     


Lys Glu Asp Leu Val Gly Lys Asp Val Thr Arg Val Tyr Gln Thr Met 
            180                 185                 190         


Ser Asn Pro Leu Ser Lys Leu Ser Val Leu Asn Asn Ser His Thr His 
        195                 200                 205             


Phe Ile Leu Ala Asp Asn Gly Thr Leu Gly Lys Tyr Gly Ala Glu Val 
    210                 215                 220                 


Lys Leu Arg Arg Leu Leu Glu Lys His Ile Ser Leu Gln Lys Ile Asn 
225                 230                 235                 240 


Thr Arg Leu Gly Gln Gly Val Pro Leu Val Gly Leu Val Val Glu Gly 
                245                 250                 255     


Gly Pro Asn Val Val Ser Ile Val Leu Glu Tyr Leu Gln Glu Glu Pro 
            260                 265                 270         


Pro Ile Pro Val Val Ile Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile 
        275                 280                 285             


Leu Ser Phe Ala His Lys Tyr Cys Glu Glu Gly Gly Ile Ile Asn Glu 
    290                 295                 300                 


Ser Leu Arg Glu Gln Leu Leu Val Thr Ile Gln Lys Thr Phe Asn Tyr 
305                 310                 315                 320 


Asn Lys Ala Gln Ser His Gln Leu Phe Ala Ile Ile Met Glu Cys Met 
                325                 330                 335     


Lys Lys Lys Glu Leu Val Thr Val Phe Arg Met Gly Ser Glu Gly Gln 
            340                 345                 350         


Gln Asp Ile Glu Met Ala Ile Leu Thr Ala Leu Leu Lys Gly Thr Asn 
        355                 360                 365             


Val Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp Asn Arg Val 
    370                 375                 380                 


Asp Ile Ala Arg Ser Gln Ile Phe Val Phe Gly Pro His Trp Pro Pro 
385                 390                 395                 400 


Leu Gly Ser Leu Ala Pro Pro Thr Asp Ser Lys Ala Thr Glu Lys Glu 
                405                 410                 415     


Lys Lys Pro Pro Met Ala Thr Thr Lys Gly Gly Arg Gly Lys Gly Lys 
            420                 425                 430         


Gly Lys Lys Lys Gly Lys Val Lys Glu Glu Val Glu Glu Glu Thr Asp 
        435                 440                 445             


Pro Arg Lys Ile Glu Leu Leu Asn Trp Val Asn Ala Leu Glu Gln Ala 
    450                 455                 460                 


Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu 
465                 470                 475                 480 


Ile Glu Asn Gly Val Asn Met Gln His Phe Leu Thr Ile Pro Arg Leu 
                485                 490                 495     


Glu Glu Leu Tyr Asn Thr Arg Leu Gly Pro Pro Asn Thr Leu His Leu 
            500                 505                 510         


Leu Val Arg Asp Val Lys Lys Ser Asn Leu Pro Pro Asp Tyr His Ile 
        515                 520                 525             


Ser Leu Ile Asp Ile Gly Leu Val Leu Glu Tyr Leu Met Gly Gly Ala 
    530                 535                 540                 


Tyr Arg Cys Asn Tyr Thr Arg Lys Asn Phe Arg Thr Leu Tyr Asn Asn 
545                 550                 555                 560 


Leu Phe Gly Pro Lys Arg Pro Lys Ala Leu Lys Leu Leu Gly Met Glu 
                565                 570                 575     


Asp Asp Glu Pro Pro Ala Lys Gly Lys Lys Lys Lys Lys Lys Lys Lys 
            580                 585                 590         


Glu Glu Glu Ile Asp Ile Asp Val Asp Asp Pro Ala Val Ser Arg Phe 
        595                 600                 605             


Gln Tyr Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg 
    610                 615                 620                 


Gln Lys Met Ala Val Phe Leu Trp Gln Arg Gly Glu Glu Ser Met Ala 
625                 630                 635                 640 


Lys Ala Leu Val Ala Cys Lys Leu Tyr Lys Ala Met Ala His Glu Ser 
                645                 650                 655     


Ser Glu Ser Asp Leu Val Asp Asp Ile Ser Gln Asp Leu Asp Asn Asn 
            660                 665                 670         


Ser Lys Asp Phe Gly Gln Leu Ala Leu Glu Leu Leu Asp Gln Ser Tyr 
        675                 680                 685             


Lys His Asp Glu Gln Ile Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys 
    690                 695                 700                 


Asn Trp Ser Asn Ser Thr Cys Leu Lys Leu Ala Val Ala Ala Lys His 
705                 710                 715                 720 


Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met 
                725                 730                 735     


Trp Met Gly Arg Leu Arg Met Arg Lys Asn Pro Gly Leu Lys Val Ile 
            740                 745                 750         


Met Gly Ile Leu Leu Pro Pro Thr Ile Leu Phe Leu Glu Phe Arg Thr 
        755                 760                 765             


Tyr Asp Asp Phe Ser Tyr Gln Thr Ser Lys Glu Asn Glu Asp Gly Lys 
    770                 775                 780                 


Glu Lys Glu Glu Glu Asn Thr Asp Ala Asn Ala Asp Ala Gly Ser Arg 
785                 790                 795                 800 


Lys Gly Asp Glu Glu Asn Glu His Lys Lys Gln Arg Ser Ile Pro Ile 
                805                 810                 815     


Gly Thr Lys Ile Cys Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp 
            820                 825                 830         


Phe Tyr Thr Ile Ser Tyr Leu Gly Tyr Leu Leu Leu Phe Asn Tyr Val 
        835                 840                 845             


Ile Leu Val Arg Met Asp Gly Trp Pro Ser Leu Gln Glu Trp Ile Val 
    850                 855                 860                 


Ile Ser Tyr Ile Val Ser Leu Ala Leu Glu Lys Ile Arg Glu Ile Leu 
865                 870                 875                 880 


Met Ser Glu Pro Gly Lys Leu Ser Gln Lys Ile Lys Val Trp Leu Gln 
                885                 890                 895     


Glu Tyr Trp Asn Ile Thr Asp Leu Val Ala Ile Ser Thr Phe Met Ile 
            900                 905                 910         


Gly Ala Ile Leu Arg Leu Gln Asn Gln Pro Tyr Met Gly Tyr Gly Arg 
        915                 920                 925             


Val Ile Tyr Cys Val Asp Ile Ile Phe Trp Tyr Ile Arg Val Leu Asp 
    930                 935                 940                 


Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile Gly 
945                 950                 955                 960 


Lys Met Met Ile Asp Met Leu Tyr Phe Val Val Ile Met Leu Val Val 
                965                 970                 975     


Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu His Pro Glu Glu 
            980                 985                 990         


Lys Pro Ser Trp Lys Leu Ala Arg  Asn Ile Phe Tyr Met  Pro Tyr Trp 
        995                 1000                 1005             


Met Ile  Tyr Gly Glu Val Phe  Ala Asp Gln Ile Asp  Leu Tyr Ala 
    1010                 1015                 1020             


Met Glu  Ile Asn Pro Pro Cys  Gly Glu Asn Leu Tyr  Asp Glu Glu 
    1025                 1030                 1035             


Gly Lys  Arg Leu Pro Pro Cys  Ile Pro Gly Ala Trp  Leu Thr Pro 
    1040                 1045                 1050             


Ala Leu  Met Ala Cys Tyr Leu  Leu Val Ala Asn Ile  Leu Leu Val 
    1055                 1060                 1065             


Asn Leu  Leu Ile Ala Val Phe  Asn Asn Thr Phe Phe  Glu Val Lys 
    1070                 1075                 1080             


Ser Ile  Ser Asn Gln Val Trp  Lys Phe Gln Arg Tyr  Gln Leu Ile 
    1085                 1090                 1095             


Met Thr  Phe His Asp Arg Pro  Val Leu Pro Pro Pro  Met Ile Ile 
    1100                 1105                 1110             


Leu Ser  His Ile Tyr Ile Ile  Ile Met Arg Leu Ser  Gly Arg Cys 
    1115                 1120                 1125             


Arg Lys  Lys Arg Glu Gly Asp  Gln Glu Glu Arg Asp  Arg Gly Leu 
    1130                 1135                 1140             


Lys Leu  Phe Leu Ser Asp Glu  Glu Leu Lys Arg Leu  His Glu Phe 
    1145                 1150                 1155             


Glu Glu  Gln Cys Val Gln Glu  His Phe Arg Glu Lys  Glu Asp Glu 
    1160                 1165                 1170             


Gln Gln  Ser Ser Ser Asp Glu  Arg Ile Arg Val Thr  Ser Glu Arg 
    1175                 1180                 1185             


Val Glu  Asn Met Ser Met Arg  Leu Glu Glu Ile Asn  Glu Arg Glu 
    1190                 1195                 1200             


Thr Phe  Met Lys Thr Ser Leu  Gln Thr Val Asp Leu  Arg Leu Ala 
    1205                 1210                 1215             


Gln Leu  Glu Glu Leu Ser Asn  Arg Met Val Asn Ala  Leu Glu Asn 
    1220                 1225                 1230             


Leu Ala  Gly Ile Asp Arg Ser  Asp Leu Ile Gln Ala  Arg Ser Arg 
    1235                 1240                 1245             


Ala Ser  Ser Glu Cys Glu Ala  Thr Tyr Leu Leu Arg  Gln Ser Ser 
    1250                 1255                 1260             


Ile Asn  Ser Ala Asp Gly Tyr  Ser Leu Tyr Arg Tyr  His Phe Asn 
    1265                 1270                 1275             


Gly Glu  Glu Leu Leu Phe Glu  Asp Thr Ser Leu Ser  Thr Ser Pro 
    1280                 1285                 1290             


Gly Thr  Gly Val Arg Lys Lys  Thr Cys Ser Phe Arg  Ile Lys Glu 
    1295                 1300                 1305             


Glu Lys  Asp Val Lys Thr His  Leu Val Pro Glu Cys  Gln Asn Ser 
    1310                 1315                 1320             


Leu His  Leu Ser Leu Gly Thr  Ser Thr Ser Ala Thr  Pro Asp Gly 
    1325                 1330                 1335             


Ser His  Leu Ala Val Asp Asp  Leu Lys Asn Ala Glu  Glu Ser Lys 
    1340                 1345                 1350             


Leu Gly  Pro Asp Ile Gly Ile  Ser Lys Glu Asp Asp  Glu Arg Gln 
    1355                 1360                 1365             


Thr Asp  Ser Lys Lys Glu Glu  Thr Ile Ser Pro Ser  Leu Asn Lys 
    1370                 1375                 1380             


Thr Asp  Val Ile His Gly Gln  Asp Lys Ser Asp Val  Gln Asn Thr 
    1385                 1390                 1395             


Gln Leu  Thr Val Glu Thr Thr  Asn Ile Glu Gly Thr  Ile Ser Tyr 
    1400                 1405                 1410             


Pro Leu  Glu Glu Thr Lys Ile  Thr Arg Tyr Phe Pro  Asp Glu Thr 
    1415                 1420                 1425             


Ile Asn  Ala Cys Lys Thr Met  Lys Ser Arg Ser Phe  Val Tyr Ser 
    1430                 1435                 1440             


Arg Gly  Arg Lys Leu Val Gly  Gly Val Asn Gln Asp  Val Glu Tyr 
    1445                 1450                 1455             


Ser Ser  Ile Thr Asp Gln Gln  Leu Thr Thr Glu Trp  Gln Cys Gln 
    1460                 1465                 1470             


Val Gln  Lys Ile Thr Arg Ser  His Ser Thr Asp Ile  Pro Tyr Ile 
    1475                 1480                 1485             


Val Ser  Glu Ala Ala Val Gln  Ala Glu His Lys Glu  Gln Phe Ala 
    1490                 1495                 1500             


Asp Met  Gln Asp Glu His His  Val Ala Glu Ala Ile  Pro Arg Ile 
    1505                 1510                 1515             


Pro Arg  Leu Ser Leu Thr Ile  Thr Asp Arg Asn Gly  Met Glu Asn 
    1520                 1525                 1530             


Leu Leu  Ser Val Lys Pro Asp  Gln Thr Leu Gly Phe  Pro Ser Leu 
    1535                 1540                 1545             


Arg Ser  Lys Ser Leu His Gly  His Pro Arg Asn Val  Lys Ser Ile 
    1550                 1555                 1560             


Gln Gly  Lys Leu Asp Arg Ser  Gly His Ala Ser Ser  Val Ser Ser 
    1565                 1570                 1575             


Leu Val  Ile Val Ser Gly Met  Thr Ala Glu Glu Lys  Lys Val Lys 
    1580                 1585                 1590             


Lys Glu  Lys Ala Ser Thr Glu  Thr Glu Cys 
    1595                 1600             


<210>  2651
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  2651

Met Gly Ser Asp Pro Ser Ala Pro Gly Arg Pro Gly Trp Thr Gly Ser 
1               5                   10                  15      


Leu Leu Gly Asp Arg Glu Glu Ala Ala Arg Pro Arg Leu Leu Pro Leu 
            20                  25                  30          


Leu Leu Val Leu Leu Gly Cys Leu Gly Leu Gly Val Ala Ala Glu Asp 
        35                  40                  45              


Ala Glu Val His Ala Glu Asn Trp Leu Arg Leu Tyr Gly Tyr Leu Pro 
    50                  55                  60                  


Gln Pro Ser Arg His Met Ser Thr Met Arg Ser Ala Gln Ile Leu Ala 
65                  70                  75                  80  


Ser Ala Leu Ala Glu Met Gln Arg Phe Tyr Gly Ile Pro Val Thr Gly 
                85                  90                  95      


Val Leu Asp Glu Glu Thr Lys Glu Trp Met Lys Arg Pro Arg Cys Gly 
            100                 105                 110         


Val Pro Asp Gln Phe Gly Val Arg Val Lys Ala Asn Leu Arg Arg Arg 
        115                 120                 125             


Arg Lys Arg Tyr Ala Leu Thr Gly Arg Lys Trp Asn Asn His His Leu 
    130                 135                 140                 


Thr Phe Ser Ile Gln Asn Tyr Thr Glu Lys Leu Gly Trp Tyr His Ser 
145                 150                 155                 160 


Met Glu Ala Val Arg Arg Ala Phe Arg Val Trp Glu Gln Ala Thr Pro 
                165                 170                 175     


Leu Val Phe Gln Glu Val Pro Tyr Glu Asp Ile Arg Leu Arg Arg Gln 
            180                 185                 190         


Lys Glu Ala Asp Ile Met Val Leu Phe Ala Ser Gly Phe His Gly Asp 
        195                 200                 205             


Ser Ser Pro Phe Asp Gly Thr Gly Gly Phe Leu Ala His Ala Tyr Phe 
    210                 215                 220                 


Pro Gly Pro Gly Leu Gly Gly Asp Thr His Phe Asp Ala Asp Glu Pro 
225                 230                 235                 240 


Trp Thr Phe Ser Ser Thr Asp Leu His Gly Asn Asn Leu Phe Leu Val 
                245                 250                 255     


Ala Val His Glu Leu Gly His Ala Leu Gly Leu Glu His Ser Ser Asn 
            260                 265                 270         


Pro Asn Ala Ile Met Ala Pro Phe Tyr Gln Trp Lys Asp Val Asp Asn 
        275                 280                 285             


Phe Lys Leu Pro Glu Asp Asp Leu Arg Gly Ile Gln Gln Leu Tyr Gly 
    290                 295                 300                 


Thr Pro Asp Gly Gln Pro Gln Pro Thr Gln Pro Leu Pro Thr Val Thr 
305                 310                 315                 320 


Pro Arg Arg Pro Gly Arg Pro Asp His Arg Pro Pro Arg Pro Pro Gln 
                325                 330                 335     


Pro Pro Pro Pro Gly Gly Lys Pro Glu Arg Pro Pro Lys Pro Gly Pro 
            340                 345                 350         


Pro Val Gln Pro Arg Ala Thr Glu Arg Pro Asp Gln Tyr Gly Pro Asn 
        355                 360                 365             


Ile Cys Asp Gly Asp Phe Asp Thr Val Ala Met Leu Arg Gly Glu Met 
    370                 375                 380                 


Phe Val Phe Lys Gly Arg Trp Phe Trp Arg Val Arg His Asn Arg Val 
385                 390                 395                 400 


Leu Asp Asn Tyr Pro Met Pro Ile Gly His Phe Trp Arg Gly Leu Pro 
                405                 410                 415     


Gly Asp Ile Ser Ala Ala Tyr Glu Arg Gln Asp Gly Arg Phe Val Phe 
            420                 425                 430         


Phe Lys Gly Asp Arg Tyr Trp Leu Phe Arg Glu Ala Asn Leu Glu Pro 
        435                 440                 445             


Gly Tyr Pro Gln Pro Leu Thr Ser Tyr Gly Leu Gly Ile Pro Tyr Asp 
    450                 455                 460                 


Arg Ile Asp Thr Ala Ile Trp Trp Glu Pro Thr Gly His Thr Phe Phe 
465                 470                 475                 480 


Phe Gln Glu Asp Arg Tyr Trp Arg Phe Asn Glu Glu Thr Gln Arg Gly 
                485                 490                 495     


Asp Pro Gly Tyr Pro Lys Pro Ile Ser Val Trp Gln Gly Ile Pro Ala 
            500                 505                 510         


Ser Pro Lys Gly Ala Phe Leu Ser Asn Asp Ala Ala Tyr Thr Tyr Phe 
        515                 520                 525             


Tyr Lys Gly Thr Lys Tyr Trp Lys Phe Asp Asn Glu Arg Leu Arg Met 
    530                 535                 540                 


Glu Pro Gly Tyr Pro Lys Ser Ile Leu Arg Asp Phe Met Gly Cys Gln 
545                 550                 555                 560 


Glu His Val Glu Pro Gly Pro Arg Trp Pro Asp Val Ala Arg Pro Pro 
                565                 570                 575     


Phe Asn Pro His Gly Gly Ala Glu Pro Gly Ala Asp Ser Ala Glu Gly 
            580                 585                 590         


Asp Val Gly Asp Gly Asp Gly Asp Phe Gly Ala Gly Val Asn Lys Asp 
        595                 600                 605             


Gly Gly Ser Arg Val Val Val Gln Met Glu Glu Val Ala Arg Thr Val 
    610                 615                 620                 


Asn Val Val Met Val Leu Val Pro Leu Leu Leu Leu Leu Cys Val Leu 
625                 630                 635                 640 


Gly Leu Thr Tyr Ala Leu Val Gln Met Gln Arg Lys Gly Ala Pro Arg 
                645                 650                 655     


Val Leu Leu Tyr Cys Lys Arg Ser Leu Gln Glu Trp Val 
            660                 665                 


<210>  2652
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  2652

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys 
        195                 200                 205             


Ile Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu 
    210                 215                 220                 


Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu 
225                 230                 235                 240 


Glu Glu Leu Leu Phe His Leu Glu Ala Leu Ser Gly 
                245                 250         


<210>  2653
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  2653

Met Val Thr Pro Ala Leu Gln Met Lys Lys Pro Lys Gln Phe Cys Arg 
1               5                   10                  15      


Arg Met Gly Gln Lys Lys Gln Arg Pro Ala Arg Ala Gly Gln Pro His 
            20                  25                  30          


Ser Ser Ser Asp Ala Ala Gln Ala Pro Ala Glu Gln Pro His Ser Ser 
        35                  40                  45              


Ser Asp Ala Ala Gln Ala Pro Cys Pro Arg Glu Arg Cys Leu Gly Pro 
    50                  55                  60                  


Pro Thr Thr Pro Gly Pro Tyr Arg Ser Ile Tyr Phe Ser Ser Pro Lys 
65                  70                  75                  80  


Gly His Leu Thr Arg Leu Gly Leu Glu Phe Phe Asp Gln Pro Ala Val 
                85                  90                  95      


Pro Leu Ala Arg Ala Phe Leu Gly Gln Val Leu Val Arg Arg Leu Pro 
            100                 105                 110         


Asn Gly Thr Glu Leu Arg Gly Arg Ile Val Glu Thr Glu Ala Tyr Leu 
        115                 120                 125             


Gly Pro Glu Asp Glu Ala Ala His Ser Arg Gly Gly Arg Gln Thr Pro 
    130                 135                 140                 


Arg Asn Arg Gly Met Phe Met Lys Pro Gly Thr Leu Tyr Val Tyr Ile 
145                 150                 155                 160 


Ile Tyr Gly Met Tyr Phe Cys Met Asn Ile Ser Ser Gln Gly Asp Gly 
                165                 170                 175     


Ala Cys Val Leu Leu Arg Ala Leu Glu Pro Leu Glu Gly Leu Glu Thr 
            180                 185                 190         


Met Arg Gln Leu Arg Ser Thr Leu Arg Lys Gly Thr Ala Ser Arg Val 
        195                 200                 205             


Leu Lys Asp Arg Glu Leu Cys Ser Gly Pro Ser Lys Leu Cys Gln Ala 
    210                 215                 220                 


Leu Ala Ile Asn Lys Ser Phe Asp Gln Arg Asp Leu Ala Gln Asp Glu 
225                 230                 235                 240 


Ala Val Trp Leu Glu Arg Gly Pro Leu Glu Pro Ser Glu Pro Ala Val 
                245                 250                 255     


Val Ala Ala Ala Arg Val Gly Val Gly His Ala Gly Glu Trp Ala Arg 
            260                 265                 270         


Lys Pro Leu Arg Phe Tyr Val Arg Gly Ser Pro Trp Val Ser Val Val 
        275                 280                 285             


Asp Arg Val Ala Glu Gln Asp Thr Gln Ala 
    290                 295             


<210>  2654
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  2654

Met Asn Val Leu Leu Gly Ser Val Val Ile Phe Ala Thr Phe Val Thr 
1               5                   10                  15      


Leu Cys Asn Ala Ser Cys Tyr Phe Ile Pro Asn Glu Gly Val Pro Gly 
            20                  25                  30          


Asp Ser Thr Arg Lys Cys Met Asp Leu Lys Gly Asn Lys His Pro Ile 
        35                  40                  45              


Asn Ser Glu Trp Gln Thr Asp Asn Cys Glu Thr Cys Thr Cys Tyr Glu 
    50                  55                  60                  


Thr Glu Ile Ser Cys Cys Thr Leu Val Ser Thr Pro Val Gly Tyr Asp 
65                  70                  75                  80  


Lys Asp Asn Cys Gln Arg Ile Phe Lys Lys Glu Asp Cys Lys Tyr Ile 
                85                  90                  95      


Val Val Glu Lys Lys Asp Pro Lys Lys Thr Cys Ser Val Ser Glu Trp 
            100                 105                 110         


Ile Ile 
        


<210>  2655
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  2655

Met Glu Gln Trp Asp His Phe His Asn Gln Gln Glu Asp Thr Asp Ser 
1               5                   10                  15      


Cys Ser Glu Ser Val Lys Phe Asp Ala Arg Ser Met Thr Ala Leu Leu 
            20                  25                  30          


Pro Pro Asn Pro Lys Asn Ser Pro Ser Leu Gln Glu Lys Leu Lys Ser 
        35                  40                  45              


Phe Lys Ala Ala Leu Ile Ala Leu Tyr Leu Leu Val Phe Ala Val Leu 
    50                  55                  60                  


Ile Pro Leu Ile Gly Ile Val Ala Ala Gln Leu Leu Lys Trp Glu Thr 
65                  70                  75                  80  


Lys Asn Cys Ser Val Ser Ser Thr Asn Ala Asn Asp Ile Thr Gln Ser 
                85                  90                  95      


Leu Thr Gly Lys Gly Asn Asp Ser Glu Glu Glu Met Arg Phe Gln Glu 
            100                 105                 110         


Val Phe Met Glu His Met Ser Asn Met Glu Lys Arg Ile Gln His Ile 
        115                 120                 125             


Leu Asp Met Glu Ala Asn Leu Met Asp Thr Glu His Phe Gln Asn Phe 
    130                 135                 140                 


Ser Met Thr Thr Asp Gln Arg Phe Asn Asp Ile Leu Leu Gln Leu Ser 
145                 150                 155                 160 


Thr Leu Phe Ser Ser Val Gln Gly His Gly Asn Ala Ile Asp Glu Ile 
                165                 170                 175     


Ser Lys Ser Leu Ile Ser Leu Asn Thr Thr Leu Leu Asp Leu Gln Leu 
            180                 185                 190         


Asn Ile Glu Asn Leu Asn Gly Lys Ile Gln Glu Asn Thr Phe Lys Gln 
        195                 200                 205             


Gln Glu Glu Ile Ser Lys Leu Glu Glu Arg Val Tyr Asn Val Ser Ala 
    210                 215                 220                 


Glu Ile Met Ala Met Lys Glu Glu Gln Val His Leu Glu Gln Glu Ile 
225                 230                 235                 240 


Lys Gly Glu Val Lys Val Leu Asn Asn Ile Thr Asn Asp Leu Arg Leu 
                245                 250                 255     


Lys Asp Trp Glu His Ser Gln Thr Leu Arg Asn Ile Thr Leu Ile Gln 
            260                 265                 270         


Gly Pro Pro Gly Pro Pro Gly Glu Lys Gly Asp Arg Gly Pro Thr Gly 
        275                 280                 285             


Glu Ser Gly Pro Arg Gly Phe Pro Gly Pro Ile Gly Pro Pro Gly Leu 
    290                 295                 300                 


Lys Gly Asp Arg Gly Ala Ile Gly Phe Pro Gly Ser Arg Gly Leu Pro 
305                 310                 315                 320 


Gly Tyr Ala Gly Arg Pro Gly Asn Ser Gly Pro Lys Gly Gln Lys Gly 
                325                 330                 335     


Glu Lys Gly Ser Gly Asn Thr Leu Arg Pro Val Gln Leu Thr Asp His 
            340                 345                 350         


Ile Arg Ala Gly Pro Ser 
        355             


<210>  2656
<211>  1400
<212>  PRT
<213>  Homo sapiens

<400>  2656

Met Glu Leu Leu Pro Pro Leu Pro Gln Ser Phe Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Ala Lys Pro Ala Ala Gly Glu Asp Trp Gln Cys Pro Arg Thr 
            20                  25                  30          


Pro Tyr Ala Ala Ser Arg Asp Phe Asp Val Lys Tyr Val Val Pro Ser 
        35                  40                  45              


Phe Ser Ala Gly Gly Leu Val Gln Ala Met Val Thr Tyr Glu Gly Asp 
    50                  55                  60                  


Arg Asn Glu Ser Ala Val Phe Val Ala Ile Arg Asn Arg Leu His Val 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Lys Ser Val Gln Ser Leu Ala Thr Gly Pro Ala 
                85                  90                  95      


Gly Asp Pro Gly Cys Gln Thr Cys Ala Ala Cys Gly Pro Gly Pro His 
            100                 105                 110         


Gly Pro Pro Gly Asp Thr Asp Thr Lys Val Leu Val Leu Asp Pro Ala 
        115                 120                 125             


Leu Pro Ala Leu Val Ser Cys Gly Ser Ser Leu Gln Gly Arg Cys Phe 
    130                 135                 140                 


Leu His Asp Leu Glu Pro Gln Gly Thr Ala Val His Leu Ala Ala Pro 
145                 150                 155                 160 


Ala Cys Leu Phe Ser Ala His His Asn Arg Pro Asp Asp Cys Pro Asp 
                165                 170                 175     


Cys Val Ala Ser Pro Leu Gly Thr Arg Val Thr Val Val Glu Gln Gly 
            180                 185                 190         


Gln Ala Ser Tyr Phe Tyr Val Ala Ser Ser Leu Asp Ala Ala Val Ala 
        195                 200                 205             


Ala Ser Phe Ser Pro Arg Ser Val Ser Ile Arg Arg Leu Lys Ala Asp 
    210                 215                 220                 


Ala Ser Gly Phe Ala Pro Gly Phe Val Ala Leu Ser Val Leu Pro Lys 
225                 230                 235                 240 


His Leu Val Ser Tyr Ser Ile Glu Tyr Val His Ser Phe His Thr Gly 
                245                 250                 255     


Ala Phe Val Tyr Phe Leu Thr Val Gln Pro Ala Ser Val Thr Asp Asp 
            260                 265                 270         


Pro Ser Ala Leu His Thr Arg Leu Ala Arg Leu Ser Ala Thr Glu Pro 
        275                 280                 285             


Glu Leu Gly Asp Tyr Arg Glu Leu Val Leu Asp Cys Arg Phe Ala Pro 
    290                 295                 300                 


Lys Arg Arg Arg Arg Gly Ala Pro Glu Gly Gly Gln Pro Tyr Pro Val 
305                 310                 315                 320 


Leu Arg Val Ala His Ser Ala Pro Val Gly Ala Gln Leu Ala Thr Glu 
                325                 330                 335     


Leu Ser Ile Ala Glu Gly Gln Glu Val Leu Phe Gly Val Phe Val Thr 
            340                 345                 350         


Gly Lys Asp Gly Gly Pro Gly Val Gly Pro Asn Ser Val Val Cys Ala 
        355                 360                 365             


Phe Pro Ile Asp Leu Leu Asp Thr Leu Ile Asp Glu Gly Val Glu Arg 
    370                 375                 380                 


Cys Cys Glu Ser Pro Val His Pro Gly Leu Arg Arg Gly Leu Asp Phe 
385                 390                 395                 400 


Phe Gln Ser Pro Ser Phe Cys Pro Asn Pro Pro Gly Leu Glu Ala Leu 
                405                 410                 415     


Ser Pro Asn Thr Ser Cys Arg His Phe Pro Leu Leu Val Ser Ser Ser 
            420                 425                 430         


Phe Ser Arg Val Asp Leu Phe Asn Gly Leu Leu Gly Pro Val Gln Val 
        435                 440                 445             


Thr Ala Leu Tyr Val Thr Arg Leu Asp Asn Val Thr Val Ala His Met 
    450                 455                 460                 


Gly Thr Met Asp Gly Arg Ile Leu Gln Val Glu Leu Val Arg Ser Leu 
465                 470                 475                 480 


Asn Tyr Leu Leu Tyr Val Ser Asn Phe Ser Leu Gly Asp Ser Gly Gln 
                485                 490                 495     


Pro Val Gln Arg Asp Val Ser Arg Leu Gly Asp His Leu Leu Phe Ala 
            500                 505                 510         


Ser Gly Asp Gln Val Phe Gln Val Pro Ile Gln Gly Pro Gly Cys Arg 
        515                 520                 525             


His Phe Leu Thr Cys Gly Arg Cys Leu Arg Ala Trp His Phe Met Gly 
    530                 535                 540                 


Cys Gly Trp Cys Gly Asn Met Cys Gly Gln Gln Lys Glu Cys Pro Gly 
545                 550                 555                 560 


Ser Trp Gln Gln Asp His Cys Pro Pro Lys Leu Thr Glu Phe His Pro 
                565                 570                 575     


His Ser Gly Pro Leu Arg Gly Ser Thr Arg Leu Thr Leu Cys Gly Ser 
            580                 585                 590         


Asn Phe Tyr Leu His Pro Ser Gly Leu Val Pro Glu Gly Thr His Gln 
        595                 600                 605             


Val Thr Val Gly Gln Ser Pro Cys Arg Pro Leu Pro Lys Asp Ser Ser 
    610                 615                 620                 


Lys Leu Arg Pro Val Pro Arg Lys Asp Phe Val Glu Glu Phe Glu Cys 
625                 630                 635                 640 


Glu Leu Glu Pro Leu Gly Thr Gln Ala Val Gly Pro Thr Asn Val Ser 
                645                 650                 655     


Leu Thr Val Thr Asn Met Pro Pro Gly Lys His Phe Arg Val Asp Gly 
            660                 665                 670         


Thr Ser Val Leu Arg Gly Phe Ser Phe Met Glu Pro Val Leu Ile Ala 
        675                 680                 685             


Val Gln Pro Leu Phe Gly Pro Arg Ala Gly Gly Thr Cys Leu Thr Leu 
    690                 695                 700                 


Glu Gly Gln Ser Leu Ser Val Gly Thr Ser Arg Ala Val Leu Val Asn 
705                 710                 715                 720 


Gly Thr Glu Cys Leu Leu Ala Arg Val Ser Glu Gly Gln Leu Leu Cys 
                725                 730                 735     


Ala Thr Pro Pro Gly Ala Thr Val Ala Ser Val Pro Leu Ser Leu Gln 
            740                 745                 750         


Val Gly Gly Ala Gln Val Pro Gly Ser Trp Thr Phe Gln Tyr Arg Glu 
        755                 760                 765             


Asp Pro Val Val Leu Ser Ile Ser Pro Asn Cys Gly Tyr Ile Asn Ser 
    770                 775                 780                 


His Ile Thr Ile Cys Gly Gln His Leu Thr Ser Ala Trp His Leu Val 
785                 790                 795                 800 


Leu Ser Phe His Asp Gly Leu Arg Ala Val Glu Ser Arg Cys Glu Arg 
                805                 810                 815     


Gln Leu Pro Glu Gln Gln Leu Cys Arg Leu Pro Glu Tyr Val Val Arg 
            820                 825                 830         


Asp Pro Gln Gly Trp Val Ala Gly Asn Leu Ser Ala Arg Gly Asp Gly 
        835                 840                 845             


Ala Ala Gly Phe Thr Leu Pro Gly Phe Arg Phe Leu Pro Pro Pro His 
    850                 855                 860                 


Pro Pro Ser Ala Asn Leu Val Pro Leu Lys Pro Glu Glu His Ala Ile 
865                 870                 875                 880 


Lys Phe Glu Tyr Ile Gly Leu Gly Ala Val Ala Asp Cys Val Gly Ile 
                885                 890                 895     


Asn Val Thr Val Gly Gly Glu Ser Cys Gln His Glu Phe Arg Gly Asp 
            900                 905                 910         


Met Val Val Cys Pro Leu Pro Pro Ser Leu Gln Leu Gly Gln Asp Gly 
        915                 920                 925             


Ala Pro Leu Gln Val Cys Val Asp Gly Glu Cys His Ile Leu Gly Arg 
    930                 935                 940                 


Val Val Arg Pro Gly Pro Asp Gly Val Pro Gln Ser Thr Leu Leu Gly 
945                 950                 955                 960 


Ile Leu Leu Pro Leu Leu Leu Leu Val Ala Ala Leu Ala Thr Ala Leu 
                965                 970                 975     


Val Phe Ser Tyr Trp Trp Arg Arg Lys Gln Leu Val Leu Pro Pro Asn 
            980                 985                 990         


Leu Asn Asp Leu Ala Ser Leu Asp  Gln Thr Ala Gly Ala  Thr Pro Leu 
        995                 1000                 1005             


Pro Ile  Leu Tyr Ser Gly Ser  Asp Tyr Arg Ser Gly  Leu Ala Leu 
    1010                 1015                 1020             


Pro Ala  Ile Asp Gly Leu Asp  Ser Thr Thr Cys Val  His Gly Ala 
    1025                 1030                 1035             


Ser Phe  Ser Asp Ser Glu Asp  Glu Ser Cys Val Pro  Leu Leu Arg 
    1040                 1045                 1050             


Lys Glu  Ser Ile Gln Leu Arg  Asp Leu Asp Ser Ala  Leu Leu Ala 
    1055                 1060                 1065             


Glu Val  Lys Asp Val Leu Ile  Pro His Glu Arg Val  Val Thr His 
    1070                 1075                 1080             


Ser Asp  Arg Val Ile Gly Lys  Gly His Phe Gly Val  Val Tyr His 
    1085                 1090                 1095             


Gly Glu  Tyr Ile Asp Gln Ala  Gln Asn Arg Ile Gln  Cys Ala Ile 
    1100                 1105                 1110             


Lys Ser  Leu Ser Arg Ile Thr  Glu Met Gln Gln Val  Glu Ala Phe 
    1115                 1120                 1125             


Leu Arg  Glu Gly Leu Leu Met  Arg Gly Leu Asn His  Pro Asn Val 
    1130                 1135                 1140             


Leu Ala  Leu Ile Gly Ile Met  Leu Pro Pro Glu Gly  Leu Pro His 
    1145                 1150                 1155             


Val Leu  Leu Pro Tyr Met Cys  His Gly Asp Leu Leu  Gln Phe Ile 
    1160                 1165                 1170             


Arg Ser  Pro Gln Arg Asn Pro  Thr Val Lys Asp Leu  Ile Ser Phe 
    1175                 1180                 1185             


Gly Leu  Gln Val Ala Arg Gly  Met Glu Tyr Leu Ala  Glu Gln Lys 
    1190                 1195                 1200             


Phe Val  His Arg Asp Leu Ala  Ala Arg Asn Cys Met  Leu Asp Glu 
    1205                 1210                 1215             


Ser Phe  Thr Val Lys Val Ala  Asp Phe Gly Leu Ala  Arg Asp Ile 
    1220                 1225                 1230             


Leu Asp  Arg Glu Tyr Tyr Ser  Val Gln Gln His Arg  His Ala Arg 
    1235                 1240                 1245             


Leu Pro  Val Lys Trp Met Ala  Leu Glu Ser Leu Gln  Thr Tyr Arg 
    1250                 1255                 1260             


Phe Thr  Thr Lys Ser Asp Val  Trp Ser Phe Gly Val  Leu Leu Trp 
    1265                 1270                 1275             


Glu Leu  Leu Thr Arg Gly Ala  Pro Pro Tyr Arg His  Ile Asp Pro 
    1280                 1285                 1290             


Phe Asp  Leu Thr His Phe Leu  Ala Gln Gly Arg Arg  Leu Pro Gln 
    1295                 1300                 1305             


Pro Glu  Tyr Cys Pro Asp Ser  Leu Tyr Gln Val Met  Gln Gln Cys 
    1310                 1315                 1320             


Trp Glu  Ala Asp Pro Ala Val  Arg Pro Thr Phe Arg  Val Leu Val 
    1325                 1330                 1335             


Gly Glu  Val Glu Gln Ile Val  Ser Ala Leu Leu Gly  Asp His Tyr 
    1340                 1345                 1350             


Val Gln  Leu Pro Ala Thr Tyr  Met Asn Leu Gly Pro  Ser Thr Ser 
    1355                 1360                 1365             


His Glu  Met Asn Val Arg Pro  Glu Gln Pro Gln Phe  Ser Pro Met 
    1370                 1375                 1380             


Pro Gly  Asn Val Arg Arg Pro  Arg Pro Leu Ser Glu  Pro Pro Arg 
    1385                 1390                 1395             


Pro Thr  
    1400 


<210>  2657
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  2657

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Leu Ser Thr Gly Val Ser Phe Phe Phe Leu Ser 
    50                  55                  60                  


Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser 
65                  70                  75                  80  


Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu 
                85                  90                  95      


Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe 
            100                 105                 110         


Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly 
        115                 120                 125             


Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 
    130                 135                 140                 


Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser 
145                 150                 155                 160 


Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly 
                165                 170                 175     


Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala 
            180                 185                 190         


Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn 
        195                 200                 205             


Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met 
    210                 215                 220                 


Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser 
225                 230                 235                 240 


Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly 
                245                 250                 255     


Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn 
            260                 265                 270         


Leu 
    


<210>  2658
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  2658

Met Leu Arg Gln Ile Ile Gly Gln Ala Lys Lys His Pro Ser Leu Ile 
1               5                   10                  15      


Pro Leu Phe Val Phe Ile Gly Thr Gly Ala Thr Gly Ala Thr Leu Tyr 
            20                  25                  30          


Leu Leu Arg Leu Ala Leu Phe Asn Pro Asp Val Cys Trp Asp Arg Asn 
        35                  40                  45              


Asn Pro Glu Pro Trp Asn Lys Leu Gly Pro Asn Asp Gln Tyr Lys Phe 
    50                  55                  60                  


Tyr Ser Val Asn Val Asp Tyr Ser Lys Leu Lys Lys Glu Arg Pro Asp 
65                  70                  75                  80  


Phe 
    


<210>  2659
<211>  26
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<400>  2659

Asx Glu Thr Ala Ser Asx Cys Met Pro Leu Glu Xaa Ser Asx Asn Ile 
1               5                   10                  15      


Thr His Met Ser Ala Pro Ile Glu Asn Ser 
            20                  25      


<210>  2660
<211>  49
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<400>  2660

Asx Glu Thr Ala Ser Asx Cys Met Pro Leu Glu Xaa Ser Asx Asn Ile 
1               5                   10                  15      


Thr Met Ile Thr Cys His Asn Asp Arg Ile Ala Leu Ile Ser Phe Arg 
            20                  25                  30          


Met Pro Arg Glu Cys Arg Ser Arg His Met Ser Ala Pro Ile Glu Asn 
        35                  40                  45              


Ser 
    


<210>  2661
<211>  31
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<400>  2661

Asx Glu Thr Ala Ser Asx Cys Met Pro Leu Glu Xaa Ser Asx Asn Ile 
1               5                   10                  15      


Thr Ile Ser Phe Arg Met His Met Ser Ala Pro Ile Glu Asn Ser 
            20                  25                  30      


<210>  2662
<211>  1461
<212>  PRT
<213>  Homo sapiens

<400>  2662

Met Ala Ala Glu Arg Gly Ala Arg Arg Leu Leu Ser Thr Pro Ser Phe 
1               5                   10                  15      


Trp Leu Tyr Cys Leu Leu Leu Leu Gly Arg Arg Ala Pro Gly Ala Ala 
            20                  25                  30          


Ala Ala Arg Ser Gly Ser Ala Pro Gln Ser Pro Gly Ala Ser Ile Arg 
        35                  40                  45              


Thr Phe Thr Pro Phe Tyr Phe Leu Val Glu Pro Val Asp Thr Leu Ser 
    50                  55                  60                  


Val Arg Gly Ser Ser Val Ile Leu Asn Cys Ser Ala Tyr Ser Glu Pro 
65                  70                  75                  80  


Ser Pro Lys Ile Glu Trp Lys Lys Asp Gly Thr Phe Leu Asn Leu Val 
                85                  90                  95      


Ser Asp Asp Arg Arg Gln Leu Leu Pro Asp Gly Ser Leu Phe Ile Ser 
            100                 105                 110         


Asn Val Val His Ser Lys His Asn Lys Pro Asp Glu Gly Tyr Tyr Gln 
        115                 120                 125             


Cys Val Ala Thr Val Glu Ser Leu Gly Thr Ile Ile Ser Arg Thr Ala 
    130                 135                 140                 


Lys Leu Ile Val Ala Gly Leu Pro Arg Phe Thr Ser Gln Pro Glu Pro 
145                 150                 155                 160 


Ser Ser Val Tyr Ala Gly Asn Asn Ala Ile Leu Asn Cys Glu Val Asn 
                165                 170                 175     


Ala Asp Leu Val Pro Phe Val Arg Trp Glu Gln Asn Arg Gln Pro Leu 
            180                 185                 190         


Leu Leu Asp Asp Arg Val Ile Lys Leu Pro Ser Gly Met Leu Val Ile 
        195                 200                 205             


Ser Asn Ala Thr Glu Gly Asp Gly Gly Leu Tyr Arg Cys Val Val Glu 
    210                 215                 220                 


Ser Gly Gly Pro Pro Lys Tyr Ser Asp Glu Val Glu Leu Lys Val Leu 
225                 230                 235                 240 


Pro Asp Pro Glu Val Ile Ser Asp Leu Val Phe Leu Lys Gln Pro Ser 
                245                 250                 255     


Pro Leu Val Arg Val Ile Gly Gln Asp Val Val Leu Pro Cys Val Ala 
            260                 265                 270         


Ser Gly Leu Pro Thr Pro Thr Ile Lys Trp Met Lys Asn Glu Glu Ala 
        275                 280                 285             


Leu Asp Thr Glu Ser Ser Glu Arg Leu Val Leu Leu Ala Gly Gly Ser 
    290                 295                 300                 


Leu Glu Ile Ser Asp Val Thr Glu Asp Asp Ala Gly Thr Tyr Phe Cys 
305                 310                 315                 320 


Ile Ala Asp Asn Gly Asn Glu Thr Ile Glu Ala Gln Ala Glu Leu Thr 
                325                 330                 335     


Val Gln Ala Gln Pro Glu Phe Leu Lys Gln Pro Thr Asn Ile Tyr Ala 
            340                 345                 350         


His Glu Ser Met Asp Ile Val Phe Glu Cys Glu Val Thr Gly Lys Pro 
        355                 360                 365             


Thr Pro Thr Val Lys Trp Val Lys Asn Gly Asp Met Val Ile Pro Ser 
    370                 375                 380                 


Asp Tyr Phe Lys Ile Val Lys Glu His Asn Leu Gln Val Leu Gly Leu 
385                 390                 395                 400 


Val Lys Ser Asp Glu Gly Phe Tyr Gln Cys Ile Ala Glu Asn Asp Val 
                405                 410                 415     


Gly Asn Ala Gln Ala Gly Ala Gln Leu Ile Ile Leu Glu His Ala Pro 
            420                 425                 430         


Ala Thr Thr Gly Pro Leu Pro Ser Ala Pro Arg Asp Val Val Ala Ser 
        435                 440                 445             


Leu Val Ser Thr Arg Phe Ile Lys Leu Thr Trp Arg Thr Pro Ala Ser 
    450                 455                 460                 


Asp Pro His Gly Asp Asn Leu Thr Tyr Ser Val Phe Tyr Thr Lys Glu 
465                 470                 475                 480 


Gly Ile Ala Arg Glu Arg Val Glu Asn Thr Ser His Pro Gly Glu Met 
                485                 490                 495     


Gln Val Thr Ile Gln Asn Leu Met Pro Ala Thr Val Tyr Ile Phe Arg 
            500                 505                 510         


Val Met Ala Gln Asn Lys His Gly Ser Gly Glu Ser Ser Ala Pro Leu 
        515                 520                 525             


Arg Val Glu Thr Gln Pro Glu Val Gln Leu Pro Gly Pro Ala Pro Asn 
    530                 535                 540                 


Leu Arg Ala Tyr Ala Ala Ser Pro Thr Ser Ile Thr Val Thr Trp Glu 
545                 550                 555                 560 


Thr Pro Val Ser Gly Asn Gly Glu Ile Gln Asn Tyr Lys Leu Tyr Tyr 
                565                 570                 575     


Met Glu Lys Gly Thr Asp Lys Glu Gln Asp Val Asp Val Ser Ser His 
            580                 585                 590         


Ser Tyr Thr Ile Asn Gly Leu Lys Lys Tyr Thr Glu Tyr Ser Phe Arg 
        595                 600                 605             


Val Val Ala Tyr Asn Lys His Gly Pro Gly Val Ser Thr Pro Asp Val 
    610                 615                 620                 


Ala Val Arg Thr Leu Ser Asp Val Pro Ser Ala Ala Pro Gln Asn Leu 
625                 630                 635                 640 


Ser Leu Glu Val Arg Asn Ser Lys Ser Ile Met Ile His Trp Gln Pro 
                645                 650                 655     


Pro Ala Pro Ala Thr Gln Asn Gly Gln Ile Thr Gly Tyr Lys Ile Arg 
            660                 665                 670         


Tyr Arg Lys Ala Ser Arg Lys Ser Asp Val Thr Glu Thr Leu Val Ser 
        675                 680                 685             


Gly Thr Gln Leu Ser Gln Leu Ile Glu Gly Leu Asp Arg Gly Thr Glu 
    690                 695                 700                 


Tyr Asn Phe Arg Val Ala Ala Leu Thr Ile Asn Gly Thr Gly Pro Ala 
705                 710                 715                 720 


Thr Asp Trp Leu Ser Ala Glu Thr Phe Glu Ser Asp Leu Asp Glu Thr 
                725                 730                 735     


Arg Val Pro Glu Val Pro Ser Ser Leu His Val Arg Pro Leu Val Thr 
            740                 745                 750         


Ser Ile Val Val Ser Trp Thr Pro Pro Glu Asn Gln Asn Ile Val Val 
        755                 760                 765             


Arg Gly Tyr Ala Ile Gly Tyr Gly Ile Gly Ser Pro His Ala Gln Thr 
    770                 775                 780                 


Ile Lys Val Asp Tyr Lys Gln Arg Tyr Tyr Thr Ile Glu Asn Leu Asp 
785                 790                 795                 800 


Pro Ser Ser His Tyr Val Ile Thr Leu Lys Ala Phe Asn Asn Val Gly 
                805                 810                 815     


Glu Gly Ile Pro Leu Tyr Glu Ser Ala Val Thr Arg Pro His Thr Asp 
            820                 825                 830         


Thr Ser Glu Val Asp Leu Phe Val Ile Asn Ala Pro Tyr Thr Pro Val 
        835                 840                 845             


Pro Asp Pro Thr Pro Met Met Pro Pro Val Gly Val Gln Ala Ser Ile 
    850                 855                 860                 


Leu Ser His Asp Thr Ile Arg Ile Thr Trp Ala Asp Asn Ser Leu Pro 
865                 870                 875                 880 


Lys His Gln Lys Ile Thr Asp Ser Arg Tyr Tyr Thr Val Arg Trp Lys 
                885                 890                 895     


Thr Asn Ile Pro Ala Asn Thr Lys Tyr Lys Asn Ala Asn Ala Thr Thr 
            900                 905                 910         


Leu Ser Tyr Leu Val Thr Gly Leu Lys Pro Asn Thr Leu Tyr Glu Phe 
        915                 920                 925             


Ser Val Met Val Thr Lys Gly Arg Arg Ser Ser Thr Trp Ser Met Thr 
    930                 935                 940                 


Ala His Gly Thr Thr Phe Glu Leu Val Pro Thr Ser Pro Pro Lys Asp 
945                 950                 955                 960 


Val Thr Val Val Ser Lys Glu Gly Lys Pro Lys Thr Ile Ile Val Asn 
                965                 970                 975     


Trp Gln Pro Pro Ser Glu Ala Asn Gly Lys Ile Thr Gly Tyr Ile Ile 
            980                 985                 990         


Tyr Tyr Ser Thr Asp Val Asn Ala  Glu Ile His Asp Trp  Val Ile Glu 
        995                 1000                 1005             


Pro Val  Val Gly Asn Arg Leu  Thr His Gln Ile Gln  Glu Leu Thr 
    1010                 1015                 1020             


Leu Asp  Thr Pro Tyr Tyr Phe  Lys Ile Gln Ala Arg  Asn Ser Lys 
    1025                 1030                 1035             


Gly Met  Gly Pro Met Ser Glu  Ala Val Gln Phe Arg  Thr Pro Lys 
    1040                 1045                 1050             


Ala Asp  Ser Ser Asp Lys Met  Pro Asn Asp Gln Ala  Ser Gly Ser 
    1055                 1060                 1065             


Gly Gly  Lys Gly Ser Arg Leu  Pro Asp Leu Gly Ser  Asp Tyr Lys 
    1070                 1075                 1080             


Pro Pro  Met Ser Gly Ser Asn  Ser Pro His Gly Ser  Pro Thr Ser 
    1085                 1090                 1095             


Pro Leu  Asp Ser Asn Met Leu  Leu Val Ile Ile Val  Ser Val Gly 
    1100                 1105                 1110             


Val Ile  Thr Ile Val Val Val  Val Ile Ile Ala Val  Phe Cys Thr 
    1115                 1120                 1125             


Arg Arg  Thr Thr Ser His Gln  Lys Lys Lys Arg Ala  Ala Cys Lys 
    1130                 1135                 1140             


Ser Val  Asn Gly Ser His Lys  Tyr Lys Gly Asn Ser  Lys Asp Val 
    1145                 1150                 1155             


Lys Pro  Pro Asp Leu Trp Ile  His His Glu Arg Leu  Glu Leu Lys 
    1160                 1165                 1170             


Pro Ile  Asp Lys Ser Pro Asp  Pro Asn Pro Ile Met  Thr Asp Thr 
    1175                 1180                 1185             


Pro Ile  Pro Arg Asn Ser Gln  Asp Ile Thr Pro Val  Asp Asn Ser 
    1190                 1195                 1200             


Met Asp  Ser Asn Ile His Gln  Arg Arg Asn Ser Tyr  Arg Gly His 
    1205                 1210                 1215             


Glu Ser  Glu Asp Ser Met Ser  Thr Leu Ala Gly Arg  Arg Gly Met 
    1220                 1225                 1230             


Arg Pro  Lys Met Met Met Pro  Phe Asp Ser Gln Pro  Pro Gln Pro 
    1235                 1240                 1245             


Val Ile  Ser Ala His Pro Ile  His Ser Leu Asp Asn  Pro His His 
    1250                 1255                 1260             


His Phe  His Ser Ser Ser Leu  Ala Ser Pro Ala Arg  Ser His Leu 
    1265                 1270                 1275             


Tyr His  Pro Gly Ser Pro Trp  Pro Ile Gly Thr Ser  Met Ser Leu 
    1280                 1285                 1290             


Ser Asp  Arg Ala Asn Ser Thr  Glu Ser Val Arg Asn  Thr Pro Ser 
    1295                 1300                 1305             


Thr Asp  Thr Met Pro Ala Ser  Ser Ser Gln Thr Cys  Cys Thr Asp 
    1310                 1315                 1320             


His Gln  Asp Pro Glu Gly Ala  Thr Ser Ser Ser Tyr  Leu Ala Ser 
    1325                 1330                 1335             


Ser Gln  Glu Glu Asp Ser Gly  Gln Ser Leu Pro Thr  Ala His Val 
    1340                 1345                 1350             


Arg Pro  Ser His Pro Leu Lys  Ser Phe Ala Val Pro  Ala Ile Pro 
    1355                 1360                 1365             


Pro Pro  Gly Pro Pro Thr Tyr  Asp Pro Ala Leu Pro  Ser Thr Pro 
    1370                 1375                 1380             


Leu Leu  Ser Gln Gln Ala Leu  Asn His His Ile His  Ser Val Lys 
    1385                 1390                 1395             


Thr Ala  Ser Ile Gly Thr Leu  Gly Arg Ser Arg Pro  Pro Met Pro 
    1400                 1405                 1410             


Val Val  Val Pro Ser Ala Pro  Glu Val Gln Glu Thr  Thr Arg Met 
    1415                 1420                 1425             


Leu Glu  Asp Ser Glu Ser Ser  Tyr Glu Pro Asp Glu  Leu Thr Lys 
    1430                 1435                 1440             


Glu Met  Ala His Leu Glu Gly  Leu Met Lys Asp Leu  Asn Ala Ile 
    1445                 1450                 1455             


Thr Thr  Ala 
    1460     


<210>  2663
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  2663

Met Gly Ala Gly Ala Thr Gly Arg Ala Met Asp Gly Pro Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Gly Val Ser Leu Gly Gly Ala Lys Glu Ala Cys 
            20                  25                  30          


Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys Lys Ala Cys Asn 
        35                  40                  45              


Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn Gln Thr Val Cys 
    50                  55                  60                  


Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val Val Ser Ala Thr 
65                  70                  75                  80  


Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu Gln Ser Met Ser 
                85                  90                  95      


Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg Cys Ala Tyr Gly 
            100                 105                 110         


Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala Cys Arg Val Cys 
        115                 120                 125             


Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp Lys Gln Asn Thr 
    130                 135                 140                 


Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala Asn His 
145                 150                 155                 160 


Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp Thr Glu Arg Gln 
                165                 170                 175     


Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu Cys Glu Glu Ile Pro 
            180                 185                 190         


Gly Arg Trp Ile Thr Arg Ser Thr Pro Pro Glu Gly Ser Asp Ser Thr 
        195                 200                 205             


Ala Pro Ser Thr Gln Glu Pro Glu Ala Pro Pro Glu Gln Asp Leu Ile 
    210                 215                 220                 


Ala Ser Thr Val Ala Gly Val Val Thr Thr Val Met Gly Ser Ser Gln 
225                 230                 235                 240 


Pro Val Val Thr Arg Gly Thr Thr Asp Asn Leu Ile Pro Val Tyr Cys 
                245                 250                 255     


Ser Ile Leu Ala Ala Val Val Val Gly Leu Val Ala Tyr Ile Ala Phe 
            260                 265                 270         


Lys Arg Trp Asn Ser Cys Lys Gln Asn Lys Gln Gly Ala Asn Ser Arg 
        275                 280                 285             


Pro Val Asn Gln Thr Pro Pro Pro Glu Gly Glu Lys Leu His Ser Asp 
    290                 295                 300                 


Ser Gly Ile Ser Val Asp Ser Gln Ser Leu His Asp Gln Gln Pro His 
305                 310                 315                 320 


Thr Gln Thr Ala Ser Gly Gln Ala Leu Lys Gly Asp Gly Gly Leu Tyr 
                325                 330                 335     


Ser Ser Leu Pro Pro Ala Lys Arg Glu Glu Val Glu Lys Leu Leu Asn 
            340                 345                 350         


Gly Ser Ala Gly Asp Thr Trp Arg His Leu Ala Gly Glu Leu Gly Tyr 
        355                 360                 365             


Gln Pro Glu His Ile Asp Ser Phe Thr His Glu Ala Cys Pro Val Arg 
    370                 375                 380                 


Ala Leu Leu Ala Ser Trp Ala Thr Gln Asp Ser Ala Thr Leu Asp Ala 
385                 390                 395                 400 


Leu Leu Ala Ala Leu Arg Arg Ile Gln Arg Ala Asp Leu Val Glu Ser 
                405                 410                 415     


Leu Cys Ser Glu Ser Thr Ala Thr Ser Pro Val 
            420                 425         


<210>  2664
<211>  560
<212>  PRT
<213>  Homo sapiens

<400>  2664

Met Glu Cys Leu Tyr Tyr Phe Leu Gly Phe Leu Leu Leu Ala Ala Arg 
1               5                   10                  15      


Leu Pro Leu Asp Ala Ala Lys Arg Phe His Asp Val Leu Gly Asn Glu 
            20                  25                  30          


Arg Pro Ser Ala Tyr Met Arg Glu His Asn Gln Leu Asn Gly Trp Ser 
        35                  40                  45              


Ser Asp Glu Asn Asp Trp Asn Glu Lys Leu Tyr Pro Val Trp Lys Arg 
    50                  55                  60                  


Gly Asp Met Arg Trp Lys Asn Ser Trp Lys Gly Gly Arg Val Gln Ala 
65                  70                  75                  80  


Val Leu Thr Ser Asp Ser Pro Ala Leu Val Gly Ser Asn Ile Thr Phe 
                85                  90                  95      


Ala Val Asn Leu Ile Phe Pro Arg Cys Gln Lys Glu Asp Ala Asn Gly 
            100                 105                 110         


Asn Ile Val Tyr Glu Lys Asn Cys Arg Asn Glu Ala Gly Leu Ser Ala 
        115                 120                 125             


Asp Pro Tyr Val Tyr Asn Trp Thr Ala Trp Ser Glu Asp Ser Asp Gly 
    130                 135                 140                 


Glu Asn Gly Thr Gly Gln Ser His His Asn Val Phe Pro Asp Gly Lys 
145                 150                 155                 160 


Pro Phe Pro His His Pro Gly Trp Arg Arg Trp Asn Phe Ile Tyr Val 
                165                 170                 175     


Phe His Thr Leu Gly Gln Tyr Phe Gln Lys Leu Gly Arg Cys Ser Val 
            180                 185                 190         


Arg Val Ser Val Asn Thr Ala Asn Val Thr Leu Gly Pro Gln Leu Met 
        195                 200                 205             


Glu Val Thr Val Tyr Arg Arg His Gly Arg Ala Tyr Val Pro Ile Ala 
    210                 215                 220                 


Gln Val Lys Asp Val Tyr Val Val Thr Asp Gln Ile Pro Val Phe Val 
225                 230                 235                 240 


Thr Met Phe Gln Lys Asn Asp Arg Asn Ser Ser Asp Glu Thr Phe Leu 
                245                 250                 255     


Lys Asp Leu Pro Ile Met Phe Asp Val Leu Ile His Asp Pro Ser His 
            260                 265                 270         


Phe Leu Asn Tyr Ser Thr Ile Asn Tyr Lys Trp Ser Phe Gly Asp Asn 
        275                 280                 285             


Thr Gly Leu Phe Val Ser Thr Asn His Thr Val Asn His Thr Tyr Val 
    290                 295                 300                 


Leu Asn Gly Thr Phe Ser Leu Asn Leu Thr Val Lys Ala Ala Ala Pro 
305                 310                 315                 320 


Gly Pro Cys Pro Pro Pro Pro Pro Pro Pro Arg Pro Ser Lys Pro Thr 
                325                 330                 335     


Pro Ser Leu Gly Pro Ala Gly Asp Asn Pro Leu Glu Leu Ser Arg Ile 
            340                 345                 350         


Pro Asp Glu Asn Cys Gln Ile Asn Arg Tyr Gly His Phe Gln Ala Thr 
        355                 360                 365             


Ile Thr Ile Val Glu Gly Ile Leu Glu Val Asn Ile Ile Gln Met Thr 
    370                 375                 380                 


Asp Val Leu Met Pro Val Pro Trp Pro Glu Ser Ser Leu Ile Asp Phe 
385                 390                 395                 400 


Val Val Thr Cys Gln Gly Ser Ile Pro Thr Glu Val Cys Thr Ile Ile 
                405                 410                 415     


Ser Asp Pro Thr Cys Glu Ile Thr Gln Asn Thr Val Cys Ser Pro Val 
            420                 425                 430         


Asp Val Asp Glu Met Cys Leu Leu Thr Val Arg Arg Thr Phe Asn Gly 
        435                 440                 445             


Ser Gly Thr Tyr Cys Val Asn Leu Thr Leu Gly Asp Asp Thr Ser Leu 
    450                 455                 460                 


Ala Leu Thr Ser Thr Leu Ile Ser Val Pro Asp Arg Asp Pro Ala Ser 
465                 470                 475                 480 


Pro Leu Arg Met Ala Asn Ser Ala Leu Ile Ser Val Gly Cys Leu Ala 
                485                 490                 495     


Ile Phe Val Thr Val Ile Ser Leu Leu Val Tyr Lys Lys His Lys Glu 
            500                 505                 510         


Tyr Asn Pro Ile Glu Asn Ser Pro Gly Asn Val Val Arg Ser Lys Gly 
        515                 520                 525             


Leu Ser Val Phe Leu Asn Arg Ala Lys Ala Val Phe Phe Pro Gly Asn 
    530                 535                 540                 


Gln Glu Lys Asp Pro Leu Leu Lys Asn Gln Glu Phe Lys Gly Val Ser 
545                 550                 555                 560 


<210>  2665
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  2665

Met Pro Ser Lys Ser Leu Ser Asn Leu Ser Val Thr Thr Gly Ala Asn 
1               5                   10                  15      


Glu Ser Gly Ser Val Pro Glu Gly Trp Glu Arg Asp Phe Leu Pro Ala 
            20                  25                  30          


Ser Asp Gly Thr Thr Thr Glu Leu Val Ile Arg Cys Val Ile Pro Ser 
        35                  40                  45              


Leu Tyr Leu Leu Ile Ile Thr Val Gly Leu Leu Gly Asn Ile Met Leu 
    50                  55                  60                  


Val Lys Ile Phe Ile Thr Asn Ser Ala Met Arg Ser Val Pro Asn Ile 
65                  70                  75                  80  


Phe Ile Ser Asn Leu Ala Ala Gly Asp Leu Leu Leu Leu Leu Thr Cys 
                85                  90                  95      


Val Pro Val Asp Ala Ser Arg Tyr Phe Phe Asp Glu Trp Met Phe Gly 
            100                 105                 110         


Lys Val Gly Cys Lys Leu Ile Pro Val Ile Gln Leu Thr Ser Val Gly 
        115                 120                 125             


Val Ser Val Phe Thr Leu Thr Ala Leu Ser Ala Asp Arg Tyr Arg Ala 
    130                 135                 140                 


Ile Val Asn Pro Met Asp Met Gln Thr Ser Gly Ala Leu Leu Arg Thr 
145                 150                 155                 160 


Cys Val Lys Ala Met Gly Ile Trp Val Val Ser Val Leu Leu Ala Val 
                165                 170                 175     


Pro Glu Ala Val Phe Ser Glu Val Ala Arg Ile Ser Ser Leu Asp Asn 
            180                 185                 190         


Ser Ser Phe Thr Ala Cys Ile Pro Tyr Pro Gln Thr Asp Glu Leu His 
        195                 200                 205             


Pro Lys Ile His Ser Val Leu Ile Phe Leu Val Tyr Phe Leu Ile Pro 
    210                 215                 220                 


Leu Ala Ile Ile Ser Ile Tyr Tyr Tyr His Ile Ala Lys Thr Leu Ile 
225                 230                 235                 240 


Lys Ser Ala His Asn Leu Pro Gly Glu Tyr Asn Glu His Thr Lys Lys 
                245                 250                 255     


Gln Met Glu Thr Arg Lys Arg Leu Ala Lys Ile Val Leu Val Phe Val 
            260                 265                 270         


Gly Cys Phe Ile Phe Cys Trp Phe Pro Asn His Ile Leu Tyr Met Tyr 
        275                 280                 285             


Arg Ser Phe Asn Tyr Asn Glu Ile Asp Pro Ser Leu Gly His Met Ile 
    290                 295                 300                 


Val Thr Leu Val Ala Arg Val Leu Ser Phe Gly Asn Ser Cys Val Asn 
305                 310                 315                 320 


Pro Phe Ala Leu Tyr Leu Leu Ser Glu Ser Phe Arg Arg His Phe Asn 
                325                 330                 335     


Ser Gln Leu Cys Cys Gly Arg Lys Ser Tyr Gln Glu Arg Gly Thr Ser 
            340                 345                 350         


Tyr Leu Leu Ser Ser Ser Ala Val Arg Met Thr Ser Leu Lys Ser Asn 
        355                 360                 365             


Ala Lys Asn Met Val Thr Asn Ser Val Leu Leu Asn Gly His Ser Met 
    370                 375                 380                 


Lys Gln Glu Met Ala Leu 
385                 390 


<210>  2666
<211>  574
<212>  PRT
<213>  Homo sapiens

<400>  2666

Met Cys Pro Arg Ala Ala Arg Ala Pro Ala Thr Leu Leu Leu Ala Leu 
1               5                   10                  15      


Gly Ala Val Leu Trp Pro Ala Ala Gly Ala Trp Glu Leu Thr Ile Leu 
            20                  25                  30          


His Thr Asn Asp Val His Ser Arg Leu Glu Gln Thr Ser Glu Asp Ser 
        35                  40                  45              


Ser Lys Cys Val Asn Ala Ser Arg Cys Met Gly Gly Val Ala Arg Leu 
    50                  55                  60                  


Phe Thr Lys Val Gln Gln Ile Arg Arg Ala Glu Pro Asn Val Leu Leu 
65                  70                  75                  80  


Leu Asp Ala Gly Asp Gln Tyr Gln Gly Thr Ile Trp Phe Thr Val Tyr 
                85                  90                  95      


Lys Gly Ala Glu Val Ala His Phe Met Asn Ala Leu Arg Tyr Asp Ala 
            100                 105                 110         


Met Ala Leu Gly Asn His Glu Phe Asp Asn Gly Val Glu Gly Leu Ile 
        115                 120                 125             


Glu Pro Leu Leu Lys Glu Ala Lys Phe Pro Ile Leu Ser Ala Asn Ile 
    130                 135                 140                 


Lys Ala Lys Gly Pro Leu Ala Ser Gln Ile Ser Gly Leu Tyr Leu Pro 
145                 150                 155                 160 


Tyr Lys Val Leu Pro Val Gly Asp Glu Val Val Gly Ile Val Gly Tyr 
                165                 170                 175     


Thr Ser Lys Glu Thr Pro Phe Leu Ser Asn Pro Gly Thr Asn Leu Val 
            180                 185                 190         


Phe Glu Asp Glu Ile Thr Ala Leu Gln Pro Glu Val Asp Lys Leu Lys 
        195                 200                 205             


Thr Leu Asn Val Asn Lys Ile Ile Ala Leu Gly His Ser Gly Phe Glu 
    210                 215                 220                 


Met Asp Lys Leu Ile Ala Gln Lys Val Arg Gly Val Asp Val Val Val 
225                 230                 235                 240 


Gly Gly His Ser Asn Thr Phe Leu Tyr Thr Gly Asn Pro Pro Ser Lys 
                245                 250                 255     


Glu Val Pro Ala Gly Lys Tyr Pro Phe Ile Val Thr Ser Asp Asp Gly 
            260                 265                 270         


Arg Lys Val Pro Val Val Gln Ala Tyr Ala Phe Gly Lys Tyr Leu Gly 
        275                 280                 285             


Tyr Leu Lys Ile Glu Phe Asp Glu Arg Gly Asn Val Ile Ser Ser His 
    290                 295                 300                 


Gly Asn Pro Ile Leu Leu Asn Ser Ser Ile Pro Glu Asp Pro Ser Ile 
305                 310                 315                 320 


Lys Ala Asp Ile Asn Lys Trp Arg Ile Lys Leu Asp Asn Tyr Ser Thr 
                325                 330                 335     


Gln Glu Leu Gly Lys Thr Ile Val Tyr Leu Asp Gly Ser Ser Gln Ser 
            340                 345                 350         


Cys Arg Phe Arg Glu Cys Asn Met Gly Asn Leu Ile Cys Asp Ala Met 
        355                 360                 365             


Ile Asn Asn Asn Leu Arg His Thr Asp Glu Met Phe Trp Asn His Val 
    370                 375                 380                 


Ser Met Cys Ile Leu Asn Gly Gly Gly Ile Arg Ser Pro Ile Asp Glu 
385                 390                 395                 400 


Arg Asn Asn Gly Thr Ile Thr Trp Glu Asn Leu Ala Ala Val Leu Pro 
                405                 410                 415     


Phe Gly Gly Thr Phe Asp Leu Val Gln Leu Lys Gly Ser Thr Leu Lys 
            420                 425                 430         


Lys Ala Phe Glu His Ser Val His Arg Tyr Gly Gln Ser Thr Gly Glu 
        435                 440                 445             


Phe Leu Gln Val Gly Gly Ile His Val Val Tyr Asp Leu Ser Arg Lys 
    450                 455                 460                 


Pro Gly Asp Arg Val Val Lys Leu Asp Val Leu Cys Thr Lys Cys Arg 
465                 470                 475                 480 


Val Pro Ser Tyr Asp Pro Leu Lys Met Asp Glu Val Tyr Lys Val Ile 
                485                 490                 495     


Leu Pro Asn Phe Leu Ala Asn Gly Gly Asp Gly Phe Gln Met Ile Lys 
            500                 505                 510         


Asp Glu Leu Leu Arg His Asp Ser Gly Asp Gln Asp Ile Asn Val Val 
        515                 520                 525             


Ser Thr Tyr Ile Ser Lys Met Lys Val Ile Tyr Pro Ala Val Glu Gly 
    530                 535                 540                 


Arg Ile Lys Phe Ser Thr Gly Ser His Cys His Gly Ser Phe Ser Leu 
545                 550                 555                 560 


Ile Phe Leu Ser Leu Trp Ala Val Ile Phe Val Leu Tyr Gln 
                565                 570                 


<210>  2667
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  2667

Met Ser Ile Leu Phe Tyr Val Ile Phe Leu Ala Tyr Leu Arg Gly Ile 
1               5                   10                  15      


Gln Gly Asn Asn Met Asp Gln Arg Ser Leu Pro Glu Asp Ser Leu Asn 
            20                  25                  30          


Ser Leu Ile Ile Lys Leu Ile Gln Ala Asp Ile Leu Lys Asn Lys Leu 
        35                  40                  45              


Ser Lys Gln Met Val Asp Val Lys Glu Asn Tyr Gln Ser Thr Leu Pro 
    50                  55                  60                  


Lys Ala Glu Ala Pro Arg Glu Pro Glu Arg Gly Gly Pro Ala Lys Ser 
65                  70                  75                  80  


Ala Phe Gln Pro Val Ile Ala Met Asp Thr Glu Leu Leu Arg Gln Gln 
                85                  90                  95      


Arg Arg Tyr Asn Ser Pro Arg Val Leu Leu Ser Asp Ser Thr Pro Leu 
            100                 105                 110         


Glu Pro Pro Pro Leu Tyr Leu Met Glu Asp Tyr Val Gly Ser Pro Val 
        115                 120                 125             


Val Ala Asn Arg Thr Ser Arg Arg Lys Arg Tyr Ala Glu His Lys Ser 
    130                 135                 140                 


His Arg Gly Glu Tyr Ser Val Cys Asp Ser Glu Ser Leu Trp Val Thr 
145                 150                 155                 160 


Asp Lys Ser Ser Ala Ile Asp Ile Arg Gly His Gln Val Thr Val Leu 
                165                 170                 175     


Gly Glu Ile Lys Thr Gly Asn Ser Pro Val Lys Gln Tyr Phe Tyr Glu 
            180                 185                 190         


Thr Arg Cys Lys Glu Ala Arg Pro Val Lys Asn Gly Cys Arg Gly Ile 
        195                 200                 205             


Asp Asp Lys His Trp Asn Ser Gln Cys Lys Thr Ser Gln Thr Tyr Val 
    210                 215                 220                 


Arg Ala Leu Thr Ser Glu Asn Asn Lys Leu Val Gly Trp Arg Trp Ile 
225                 230                 235                 240 


Arg Ile Asp Thr Ser Cys Val Cys Ala Leu Ser Arg Lys Ile Gly Arg 
                245                 250                 255     


Thr 
    


<210>  2668
<211>  796
<212>  PRT
<213>  Homo sapiens

<400>  2668

Met Leu Arg Gly Gly Arg Arg Gly Gln Leu Gly Trp His Ser Trp Ala 
1               5                   10                  15      


Ala Gly Pro Gly Ser Leu Leu Ala Trp Leu Ile Leu Ala Ser Ala Gly 
            20                  25                  30          


Ala Ala Pro Cys Pro Asp Ala Cys Cys Pro His Gly Ser Ser Gly Leu 
        35                  40                  45              


Arg Cys Thr Arg Asp Gly Ala Leu Asp Ser Leu His His Leu Pro Gly 
    50                  55                  60                  


Ala Glu Asn Leu Thr Glu Leu Tyr Ile Glu Asn Gln Gln His Leu Gln 
65                  70                  75                  80  


His Leu Glu Leu Arg Asp Leu Arg Gly Leu Gly Glu Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Lys Ser Gly Leu Arg Phe Val Ala Pro Asp Ala Phe His 
            100                 105                 110         


Phe Thr Pro Arg Leu Ser Arg Leu Asn Leu Ser Phe Asn Ala Leu Glu 
        115                 120                 125             


Ser Leu Ser Trp Lys Thr Val Gln Gly Leu Ser Leu Gln Glu Leu Val 
    130                 135                 140                 


Leu Ser Gly Asn Pro Leu His Cys Ser Cys Ala Leu Arg Trp Leu Gln 
145                 150                 155                 160 


Arg Trp Glu Glu Glu Gly Leu Gly Gly Val Pro Glu Gln Lys Leu Gln 
                165                 170                 175     


Cys His Gly Gln Gly Pro Leu Ala His Met Pro Asn Ala Ser Cys Gly 
            180                 185                 190         


Val Pro Thr Leu Lys Val Gln Val Pro Asn Ala Ser Val Asp Val Gly 
        195                 200                 205             


Asp Asp Val Leu Leu Arg Cys Gln Val Glu Gly Arg Gly Leu Glu Gln 
    210                 215                 220                 


Ala Gly Trp Ile Leu Thr Glu Leu Glu Gln Ser Ala Thr Val Met Lys 
225                 230                 235                 240 


Ser Gly Gly Leu Pro Ser Leu Gly Leu Thr Leu Ala Asn Val Thr Ser 
                245                 250                 255     


Asp Leu Asn Arg Lys Asn Val Thr Cys Trp Ala Glu Asn Asp Val Gly 
            260                 265                 270         


Arg Ala Glu Val Ser Val Gln Val Asn Val Ser Phe Pro Ala Ser Val 
        275                 280                 285             


Gln Leu His Thr Ala Val Glu Met His His Trp Cys Ile Pro Phe Ser 
    290                 295                 300                 


Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser 
305                 310                 315                 320 


Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Ala 
                325                 330                 335     


Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr 
            340                 345                 350         


His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Phe Gly 
        355                 360                 365             


Gln Ala Ser Ala Ser Ile Met Ala Ala Phe Met Asp Asn Pro Phe Glu 
    370                 375                 380                 


Phe Asn Pro Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr 
385                 390                 395                 400 


Asn Ser Thr Ser Gly Asp Pro Val Glu Lys Lys Asp Glu Thr Pro Phe 
                405                 410                 415     


Gly Val Ser Val Ala Val Gly Leu Ala Val Phe Ala Cys Leu Phe Leu 
            420                 425                 430         


Ser Thr Leu Leu Leu Val Leu Asn Lys Cys Gly Arg Arg Asn Lys Phe 
        435                 440                 445             


Gly Ile Asn Arg Pro Ala Val Leu Ala Pro Glu Asp Gly Leu Ala Met 
    450                 455                 460                 


Ser Leu His Phe Met Thr Leu Gly Gly Ser Ser Leu Ser Pro Thr Glu 
465                 470                 475                 480 


Gly Lys Gly Ser Gly Leu Gln Gly His Ile Ile Glu Asn Pro Gln Tyr 
                485                 490                 495     


Phe Ser Asp Ala Cys Val His His Ile Lys Arg Arg Asp Ile Val Leu 
            500                 505                 510         


Lys Trp Glu Leu Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu 
        515                 520                 525             


Cys His Asn Leu Leu Pro Glu Gln Asp Lys Met Leu Val Ala Val Lys 
    530                 535                 540                 


Ala Leu Lys Glu Ala Ser Glu Ser Ala Arg Gln Asp Phe Gln Arg Glu 
545                 550                 555                 560 


Ala Glu Leu Leu Thr Met Leu Gln His Gln His Ile Val Arg Phe Phe 
                565                 570                 575     


Gly Val Cys Thr Glu Gly Arg Pro Leu Leu Met Val Phe Glu Tyr Met 
            580                 585                 590         


Arg His Gly Asp Leu Asn Arg Phe Leu Arg Ser His Gly Pro Asp Ala 
        595                 600                 605             


Lys Leu Leu Ala Gly Gly Glu Asp Val Ala Pro Gly Pro Leu Gly Leu 
    610                 615                 620                 


Gly Gln Leu Leu Ala Val Ala Ser Gln Val Ala Ala Gly Met Val Tyr 
625                 630                 635                 640 


Leu Ala Gly Leu His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys 
                645                 650                 655     


Leu Val Gly Gln Gly Leu Val Val Lys Ile Gly Asp Phe Gly Met Ser 
            660                 665                 670         


Arg Asp Ile Tyr Ser Thr Asp Tyr Tyr Arg Val Gly Gly Arg Thr Met 
        675                 680                 685             


Leu Pro Ile Arg Trp Met Pro Pro Glu Ser Ile Leu Tyr Arg Lys Phe 
    690                 695                 700                 


Thr Thr Glu Ser Asp Val Trp Ser Phe Gly Val Val Leu Trp Glu Ile 
705                 710                 715                 720 


Phe Thr Tyr Gly Lys Gln Pro Trp Tyr Gln Leu Ser Asn Thr Glu Ala 
                725                 730                 735     


Ile Asp Cys Ile Thr Gln Gly Arg Glu Leu Glu Arg Pro Arg Ala Cys 
            740                 745                 750         


Pro Pro Glu Val Tyr Ala Ile Met Arg Gly Cys Trp Gln Arg Glu Pro 
        755                 760                 765             


Gln Gln Arg His Ser Ile Lys Asp Val His Ala Arg Leu Gln Ala Leu 
    770                 775                 780                 


Ala Gln Ala Pro Pro Val Tyr Leu Asp Val Leu Gly 
785                 790                 795     


<210>  2669
<211>  825
<212>  PRT
<213>  Homo sapiens

<400>  2669

Met Asp Val Ser Leu Cys Pro Ala Lys Cys Ser Phe Trp Arg Ile Phe 
1               5                   10                  15      


Leu Leu Gly Ser Val Trp Leu Asp Tyr Val Gly Ser Val Leu Ala Cys 
            20                  25                  30          


Pro Ala Asn Cys Val Cys Ser Lys Thr Glu Ile Asn Cys Arg Arg Pro 
        35                  40                  45              


Asp Asp Gly Asn Leu Phe Pro Leu Leu Glu Gly Gln Asp Ser Gly Asn 
    50                  55                  60                  


Ser Asn Gly Asn Ala Ser Ile Asn Ile Thr Asp Ile Ser Arg Asn Ile 
65                  70                  75                  80  


Thr Ser Ile His Ile Glu Asn Trp Arg Ser Leu His Thr Leu Asn Ala 
                85                  90                  95      


Val Asp Met Glu Leu Tyr Thr Gly Leu Gln Lys Leu Thr Ile Lys Asn 
            100                 105                 110         


Ser Gly Leu Arg Ser Ile Gln Pro Arg Ala Phe Ala Lys Asn Pro His 
        115                 120                 125             


Leu Arg Tyr Ile Asn Leu Ser Ser Asn Arg Leu Thr Thr Leu Ser Trp 
    130                 135                 140                 


Gln Leu Phe Gln Thr Leu Ser Leu Arg Glu Leu Gln Leu Glu Gln Asn 
145                 150                 155                 160 


Phe Phe Asn Cys Ser Cys Asp Ile Arg Trp Met Gln Leu Trp Gln Glu 
                165                 170                 175     


Gln Gly Glu Ala Lys Leu Asn Ser Gln Asn Leu Tyr Cys Ile Asn Ala 
            180                 185                 190         


Asp Gly Ser Gln Leu Pro Leu Phe Arg Met Asn Ile Ser Gln Cys Asp 
        195                 200                 205             


Leu Pro Glu Ile Ser Val Ser His Val Asn Leu Thr Val Arg Glu Gly 
    210                 215                 220                 


Asp Asn Ala Val Ile Thr Cys Asn Gly Ser Gly Ser Pro Leu Pro Asp 
225                 230                 235                 240 


Val Asp Trp Ile Val Thr Gly Leu Gln Ser Ile Asn Thr His Gln Thr 
                245                 250                 255     


Asn Leu Asn Trp Thr Asn Val His Ala Ile Asn Leu Thr Leu Val Asn 
            260                 265                 270         


Val Thr Ser Glu Asp Asn Gly Phe Thr Leu Thr Cys Ile Ala Glu Asn 
        275                 280                 285             


Val Val Gly Met Ser Asn Ala Ser Val Ala Leu Thr Val Tyr Tyr Pro 
    290                 295                 300                 


Pro Arg Val Val Ser Leu Glu Glu Pro Glu Leu Arg Leu Glu His Cys 
305                 310                 315                 320 


Ile Glu Phe Val Val Arg Gly Asn Pro Pro Pro Thr Leu His Trp Leu 
                325                 330                 335     


His Asn Gly Gln Pro Leu Arg Glu Ser Lys Ile Ile His Val Glu Tyr 
            340                 345                 350         


Tyr Gln Glu Gly Glu Ile Ser Glu Gly Cys Leu Leu Phe Asn Lys Pro 
        355                 360                 365             


Thr His Tyr Asn Asn Gly Asn Tyr Thr Leu Ile Ala Lys Asn Pro Leu 
    370                 375                 380                 


Gly Thr Ala Asn Gln Thr Ile Asn Gly His Phe Leu Lys Glu Pro Phe 
385                 390                 395                 400 


Pro Glu Ser Thr Asp Asn Phe Ile Leu Phe Asp Glu Val Ser Pro Thr 
                405                 410                 415     


Pro Pro Ile Thr Val Thr His Lys Pro Glu Glu Asp Thr Phe Gly Val 
            420                 425                 430         


Ser Ile Ala Val Gly Leu Ala Ala Phe Ala Cys Val Leu Leu Val Val 
        435                 440                 445             


Leu Phe Val Met Ile Asn Lys Tyr Gly Arg Arg Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Gly Pro Val Ala Val Ile Ser Gly Glu Glu Asp Ser Ala Ser Pro 
465                 470                 475                 480 


Leu His His Ile Asn His Gly Ile Thr Thr Pro Ser Ser Leu Asp Ala 
                485                 490                 495     


Gly Pro Asp Thr Val Val Ile Gly Met Thr Arg Ile Pro Val Ile Glu 
            500                 505                 510         


Asn Pro Gln Tyr Phe Arg Gln Gly His Asn Cys His Lys Pro Asp Thr 
        515                 520                 525             


Tyr Val Gln His Ile Lys Arg Arg Asp Ile Val Leu Lys Arg Glu Leu 
    530                 535                 540                 


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu 
545                 550                 555                 560 


Ser Pro Thr Lys Asp Lys Met Leu Val Ala Val Lys Ala Leu Lys Asp 
                565                 570                 575     


Pro Thr Leu Ala Ala Arg Lys Asp Phe Gln Arg Glu Ala Glu Leu Leu 
            580                 585                 590         


Thr Asn Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Gly 
        595                 600                 605             


Asp Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp 
    610                 615                 620                 


Leu Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala Met Ile Leu Val 
625                 630                 635                 640 


Asp Gly Gln Pro Arg Gln Ala Lys Gly Glu Leu Gly Leu Ser Gln Met 
                645                 650                 655     


Leu His Ile Ala Ser Gln Ile Ala Ser Gly Met Val Tyr Leu Ala Ser 
            660                 665                 670         


Gln His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly 
        675                 680                 685             


Ala Asn Leu Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val 
    690                 695                 700                 


Tyr Ser Thr Asp Tyr Tyr Arg Val Gly Gly His Thr Met Leu Pro Ile 
705                 710                 715                 720 


Arg Trp Met Pro Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu 
                725                 730                 735     


Ser Asp Val Trp Ser Phe Gly Val Ile Leu Trp Glu Ile Phe Thr Tyr 
            740                 745                 750         


Gly Lys Gln Pro Trp Phe Gln Leu Ser Asn Thr Glu Val Ile Glu Cys 
        755                 760                 765             


Ile Thr Gln Gly Arg Val Leu Glu Arg Pro Arg Val Cys Pro Lys Glu 
    770                 775                 780                 


Val Tyr Asp Val Met Leu Gly Cys Trp Gln Arg Glu Pro Gln Gln Arg 
785                 790                 795                 800 


Leu Asn Ile Lys Glu Ile Tyr Lys Ile Leu His Ala Leu Gly Lys Ala 
                805                 810                 815     


Thr Pro Ile Tyr Leu Asp Ile Leu Gly 
            820                 825 


<210>  2670
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  2670

Met Arg Leu Asn Ser Ser Ala Pro Gly Thr Pro Gly Thr Pro Ala Ala 
1               5                   10                  15      


Asp Pro Phe Gln Arg Ala Gln Ala Gly Leu Glu Glu Ala Leu Leu Ala 
            20                  25                  30          


Pro Gly Phe Gly Asn Ala Ser Gly Asn Ala Ser Glu Arg Val Leu Ala 
        35                  40                  45              


Ala Pro Ser Ser Glu Leu Asp Val Asn Thr Asp Ile Tyr Ser Lys Val 
    50                  55                  60                  


Leu Val Thr Ala Val Tyr Leu Ala Leu Phe Val Val Gly Thr Val Gly 
65                  70                  75                  80  


Asn Thr Val Thr Ala Phe Thr Leu Ala Arg Lys Lys Ser Leu Gln Ser 
                85                  90                  95      


Leu Gln Ser Thr Val His Tyr His Leu Gly Ser Leu Ala Leu Ser Asp 
            100                 105                 110         


Leu Leu Thr Leu Leu Leu Ala Met Pro Val Glu Leu Tyr Asn Phe Ile 
        115                 120                 125             


Trp Val His His Pro Trp Ala Phe Gly Asp Ala Gly Cys Arg Gly Tyr 
    130                 135                 140                 


Tyr Phe Leu Arg Asp Ala Cys Thr Tyr Ala Thr Ala Leu Asn Val Ala 
145                 150                 155                 160 


Ser Leu Ser Val Glu Arg Tyr Leu Ala Ile Cys His Pro Phe Lys Ala 
                165                 170                 175     


Lys Thr Leu Met Ser Arg Ser Arg Thr Lys Lys Phe Ile Ser Ala Ile 
            180                 185                 190         


Trp Leu Ala Ser Ala Leu Leu Ala Val Pro Met Leu Phe Thr Met Gly 
        195                 200                 205             


Glu Gln Asn Arg Ser Ala Asp Gly Gln His Ala Gly Gly Leu Val Cys 
    210                 215                 220                 


Thr Pro Thr Ile His Thr Ala Thr Val Lys Val Val Ile Gln Val Asn 
225                 230                 235                 240 


Thr Phe Met Ser Phe Ile Phe Pro Met Val Val Ile Ser Val Leu Asn 
                245                 250                 255     


Thr Ile Ile Ala Asn Lys Leu Thr Val Met Val Arg Gln Ala Ala Glu 
            260                 265                 270         


Gln Gly Gln Val Cys Thr Val Gly Gly Glu His Ser Thr Phe Ser Met 
        275                 280                 285             


Ala Ile Glu Pro Gly Arg Val Gln Ala Leu Arg His Gly Val Arg Val 
    290                 295                 300                 


Leu Arg Ala Val Val Ile Ala Phe Val Val Cys Trp Leu Pro Tyr His 
305                 310                 315                 320 


Val Arg Arg Leu Met Phe Cys Tyr Ile Ser Asp Glu Gln Trp Thr Pro 
                325                 330                 335     


Phe Leu Tyr Asp Phe Tyr His Tyr Phe Tyr Met Val Thr Asn Ala Leu 
            340                 345                 350         


Phe Tyr Val Ser Ser Thr Ile Asn Pro Ile Leu Tyr Asn Leu Val Ser 
        355                 360                 365             


Ala Asn Phe Arg His Ile Phe Leu Ala Thr Leu Ala Cys Leu Cys Pro 
    370                 375                 380                 


Val Trp Arg Arg Arg Arg Lys Arg Pro Ala Phe Ser Arg Lys Ala Asp 
385                 390                 395                 400 


Ser Val Ser Ser Asn His Thr Leu Ser Ser Asn Ala Thr Arg Glu Thr 
                405                 410                 415     


Leu Tyr 
        


<210>  2671
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  2671

Met Thr Phe Asp Asp Leu Lys Ile Gln Thr Val Lys Asp Gln Pro Asp 
1               5                   10                  15      


Glu Lys Ser Asn Gly Lys Lys Ala Lys Gly Leu Gln Phe Leu Tyr Ser 
            20                  25                  30          


Pro Trp Trp Cys Leu Ala Ala Ala Thr Leu Gly Val Leu Cys Leu Gly 
        35                  40                  45              


Leu Val Val Thr Ile Met Val Leu Gly Met Gln Leu Ser Gln Val Ser 
    50                  55                  60                  


Asp Leu Leu Thr Gln Glu Gln Ala Asn Leu Thr His Gln Lys Lys Lys 
65                  70                  75                  80  


Leu Glu Gly Gln Ile Ser Ala Arg Gln Gln Ala Glu Glu Ala Ser Gln 
                85                  90                  95      


Glu Ser Glu Asn Glu Leu Lys Glu Met Ile Glu Thr Leu Ala Arg Lys 
            100                 105                 110         


Leu Asn Glu Lys Ser Lys Glu Gln Met Glu Leu His His Gln Asn Leu 
        115                 120                 125             


Asn Leu Gln Glu Thr Leu Lys Arg Val Ala Asn Cys Ser Ala Pro Cys 
    130                 135                 140                 


Pro Gln Asp Trp Ile Trp His Gly Glu Asn Cys Tyr Leu Phe Ser Ser 
145                 150                 155                 160 


Gly Ser Phe Asn Trp Glu Lys Ser Gln Glu Lys Cys Leu Ser Leu Asp 
                165                 170                 175     


Ala Lys Leu Leu Lys Ile Asn Ser Thr Ala Asp Leu Asp Phe Ile Gln 
            180                 185                 190         


Gln Ala Ile Ser Tyr Ser Ser Phe Pro Phe Trp Met Gly Leu Ser Arg 
        195                 200                 205             


Arg Asn Pro Ser Tyr Pro Trp Leu Trp Glu Asp Gly Ser Pro Leu Met 
    210                 215                 220                 


Pro His Leu Phe Arg Val Arg Gly Ala Val Ser Gln Thr Tyr Pro Ser 
225                 230                 235                 240 


Gly Thr Cys Ala Tyr Ile Gln Arg Gly Ala Val Tyr Ala Glu Asn Cys 
                245                 250                 255     


Ile Leu Ala Ala Phe Ser Ile Cys Gln Lys Lys Ala Asn Leu Arg Ala 
            260                 265                 270         


Gln 
    


<210>  2672
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  2672

Met Glu Tyr Gln Ile Leu Lys Met Ser Leu Cys Leu Phe Ile Leu Leu 
1               5                   10                  15      


Phe Leu Thr Pro Gly Ile Leu Cys Ile Cys Pro Leu Gln Cys Ile Cys 
            20                  25                  30          


Thr Glu Arg His Arg His Val Asp Cys Ser Gly Arg Asn Leu Ser Thr 
        35                  40                  45              


Leu Pro Ser Gly Leu Gln Glu Asn Ile Ile His Leu Asn Leu Ser Tyr 
    50                  55                  60                  


Asn His Phe Thr Asp Leu His Asn Gln Leu Thr Gln Tyr Thr Asn Leu 
65                  70                  75                  80  


Arg Thr Leu Asp Ile Ser Asn Asn Arg Leu Glu Ser Leu Pro Ala His 
                85                  90                  95      


Leu Pro Arg Ser Leu Trp Asn Met Ser Ala Ala Asn Asn Asn Ile Lys 
            100                 105                 110         


Leu Leu Asp Lys Ser Asp Thr Ala Tyr Gln Trp Asn Leu Lys Tyr Leu 
        115                 120                 125             


Asp Val Ser Lys Asn Met Leu Glu Lys Val Val Leu Ile Lys Asn Thr 
    130                 135                 140                 


Leu Arg Ser Leu Glu Val Leu Asn Leu Ser Ser Asn Lys Leu Trp Thr 
145                 150                 155                 160 


Val Pro Thr Asn Met Pro Ser Lys Leu His Ile Val Asp Leu Ser Asn 
                165                 170                 175     


Asn Ser Leu Thr Gln Ile Leu Pro Gly Thr Leu Ile Asn Leu Thr Asn 
            180                 185                 190         


Leu Thr His Leu Tyr Leu His Asn Asn Lys Phe Thr Phe Ile Pro Asp 
        195                 200                 205             


Gln Ser Phe Asp Gln Leu Phe Gln Leu Gln Glu Ile Thr Leu Tyr Asn 
    210                 215                 220                 


Asn Arg Trp Ser Cys Asp His Lys Gln Asn Ile Thr Tyr Leu Leu Lys 
225                 230                 235                 240 


Trp Met Met Glu Thr Lys Ala His Val Ile Gly Thr Pro Cys Ser Thr 
                245                 250                 255     


Gln Ile Ser Ser Leu Lys Glu His Asn Met Tyr Pro Thr Pro Ser Gly 
            260                 265                 270         


Phe Thr Ser Ser Leu Phe Thr Val Ser Gly Met Gln Thr Val Asp Thr 
        275                 280                 285             


Ile Asn Ser Leu Ser Val Val Thr Gln Pro Lys Val Thr Lys Ile Pro 
    290                 295                 300                 


Lys Gln Tyr Arg Thr Lys Glu Thr Thr Phe Gly Ala Thr Leu Ser Lys 
305                 310                 315                 320 


Asp Thr Thr Phe Thr Ser Thr Asp Lys Ala Phe Val Pro Tyr Pro Glu 
                325                 330                 335     


Asp Thr Ser Thr Glu Thr Ile Asn Ser His Glu Ala Ala Ala Ala Thr 
            340                 345                 350         


Leu Thr Ile His Leu Gln Asp Gly Met Val Thr Asn Thr Ser Leu Thr 
        355                 360                 365             


Ser Ser Thr Lys Ser Ser Pro Thr Pro Met Thr Leu Ser Ile Thr Ser 
    370                 375                 380                 


Gly Met Pro Asn Asn Phe Ser Glu Met Pro Gln Gln Ser Thr Thr Leu 
385                 390                 395                 400 


Asn Leu Trp Arg Glu Glu Thr Thr Thr Asn Val Lys Thr Pro Leu Pro 
                405                 410                 415     


Ser Val Ala Asn Ala Trp Lys Val Asn Ala Ser Phe Leu Leu Leu Leu 
            420                 425                 430         


Asn Val Val Val Met Leu Ala Val 
        435                 440 


<210>  2673
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  2673

Met Gly Val Cys Gly Tyr Leu Phe Leu Pro Trp Lys Cys Leu Val Val 
1               5                   10                  15      


Val Ser Leu Arg Leu Leu Phe Leu Val Pro Thr Gly Val Pro Val Arg 
            20                  25                  30          


Ser Gly Asp Ala Thr Phe Pro Lys Ala Met Asp Asn Val Thr Val Arg 
        35                  40                  45              


Gln Gly Glu Ser Ala Thr Leu Arg Cys Thr Ile Asp Asp Arg Val Thr 
    50                  55                  60                  


Arg Val Ala Trp Leu Asn Arg Ser Thr Ile Leu Tyr Ala Gly Asn Asp 
65                  70                  75                  80  


Lys Trp Ser Ile Asp Pro Arg Val Ile Ile Leu Val Asn Thr Pro Thr 
                85                  90                  95      


Gln Tyr Ser Ile Met Ile Gln Asn Val Asp Val Tyr Asp Glu Gly Pro 
            100                 105                 110         


Tyr Thr Cys Ser Val Gln Thr Asp Asn His Pro Lys Thr Ser Arg Val 
        115                 120                 125             


His Leu Ile Val Gln Val Pro Pro Gln Ile Met Asn Ile Ser Ser Asp 
    130                 135                 140                 


Ile Thr Val Asn Glu Gly Ser Ser Val Thr Leu Leu Cys Leu Ala Ile 
145                 150                 155                 160 


Gly Arg Pro Glu Pro Thr Val Thr Trp Arg His Leu Ser Val Lys Glu 
                165                 170                 175     


Gly Gln Gly Phe Val Ser Glu Asp Glu Tyr Leu Glu Ile Ser Asp Ile 
            180                 185                 190         


Lys Arg Asp Gln Ser Gly Glu Tyr Glu Cys Ser Ala Leu Asn Asp Val 
        195                 200                 205             


Ala Ala Pro Asp Val Arg Lys Val Lys Ile Thr Val Asn Tyr Pro Pro 
    210                 215                 220                 


Tyr Ile Ser Lys Ala Lys Asn Thr Gly Val Ser Val Gly Gln Lys Gly 
225                 230                 235                 240 


Ile Leu Ser Cys Glu Ala Ser Ala Val Pro Met Ala Glu Phe Gln Trp 
                245                 250                 255     


Phe Lys Glu Glu Thr Arg Leu Ala Thr Gly Leu Asp Gly Met Arg Ile 
            260                 265                 270         


Glu Asn Lys Gly Arg Met Ser Thr Leu Thr Phe Phe Asn Val Ser Glu 
        275                 280                 285             


Lys Asp Tyr Gly Asn Tyr Thr Cys Val Ala Thr Asn Lys Leu Gly Asn 
    290                 295                 300                 


Thr Asn Ala Ser Ile Thr Leu Tyr Gly Pro Gly Ala Val Ile Asp Gly 
305                 310                 315                 320 


Val Asn Ser Ala Ser Arg Ala Leu Ala Cys Leu Trp Leu Ser Gly Thr 
                325                 330                 335     


Leu Leu Ala His Phe Phe Ile Lys Phe 
            340                 345 


<210>  2674
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  2674

Met Asp Gly Gly Asn Gln Ser Glu Gly Ser Glu Phe Leu Leu Leu Gly 
1               5                   10                  15      


Met Ser Glu Ser Pro Glu Gln Gln Arg Ile Leu Phe Trp Met Phe Leu 
            20                  25                  30          


Ser Met Tyr Leu Val Thr Val Val Gly Asn Val Leu Ile Ile Leu Ala 
        35                  40                  45              


Ile Ser Ser Asp Ser Arg Leu His Thr Pro Val Tyr Phe Phe Leu Ala 
    50                  55                  60                  


Asn Leu Ser Phe Thr Asp Leu Phe Phe Val Thr Asn Thr Ile Pro Lys 
65                  70                  75                  80  


Met Leu Val Asn Leu Gln Ser His Asn Lys Ala Ile Ser Tyr Ala Gly 
                85                  90                  95      


Cys Leu Thr Gln Leu Tyr Phe Leu Val Ser Leu Val Ala Leu Asp Asn 
            100                 105                 110         


Leu Ile Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Cys 
        115                 120                 125             


Pro Leu His Tyr Thr Thr Ala Met Ser Pro Lys Leu Cys Ile Leu Leu 
    130                 135                 140                 


Leu Ser Leu Cys Trp Val Leu Ser Val Leu Tyr Gly Leu Ile His Thr 
145                 150                 155                 160 


Leu Leu Met Thr Arg Val Thr Phe Cys Gly Ser Arg Lys Ile His Tyr 
                165                 170                 175     


Ile Phe Cys Glu Met Tyr Val Leu Leu Arg Met Ala Cys Ser Asn Ile 
            180                 185                 190         


Gln Ile Asn His Thr Val Leu Ile Ala Thr Gly Cys Phe Ile Phe Leu 
        195                 200                 205             


Ile Pro Phe Gly Phe Val Ile Ile Ser Tyr Val Leu Ile Ile Arg Ala 
    210                 215                 220                 


Ile Leu Arg Ile Pro Ser Val Ser Lys Lys Tyr Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Ala Ser His Leu Gly Ala Val Ser Leu Phe Tyr Gly Thr Leu Cys 
                245                 250                 255     


Met Val Tyr Leu Lys Pro Leu His Thr Tyr Ser Val Lys Asp Ser Val 
            260                 265                 270         


Ala Thr Val Met Tyr Ala Val Val Thr Pro Met Met Asn Pro Phe Ile 
        275                 280                 285             


Tyr Ser Leu Arg Asn Lys Asp Met His Gly Ala Leu Gly Arg Leu Leu 
    290                 295                 300                 


Asp Lys His Phe Lys Arg Leu Thr 
305                 310         


<210>  2675
<211>  315
<212>  PRT
<213>  Homo sapiens

<400>  2675

Met Gln Pro Glu Ser Gly Ala Asn Gly Thr Val Ile Ala Glu Phe Ile 
1               5                   10                  15      


Leu Leu Gly Leu Leu Glu Ala Pro Gly Leu Gln Pro Val Val Phe Val 
            20                  25                  30          


Leu Phe Leu Phe Ala Tyr Leu Val Thr Val Arg Gly Asn Leu Ser Ile 
        35                  40                  45              


Leu Ala Ala Val Leu Val Glu Pro Lys Leu His Thr Pro Met Tyr Phe 
    50                  55                  60                  


Phe Leu Gly Asn Leu Ser Val Leu Asp Val Gly Cys Ile Ser Val Thr 
65                  70                  75                  80  


Val Pro Ser Met Leu Ser Arg Leu Leu Ser Arg Lys Arg Ala Val Pro 
                85                  90                  95      


Cys Gly Ala Cys Leu Thr Gln Leu Phe Phe Phe His Leu Phe Val Gly 
            100                 105                 110         


Val Asp Cys Phe Leu Leu Thr Ala Met Ala Tyr Asp Arg Phe Leu Ala 
        115                 120                 125             


Ile Cys Arg Pro Leu Thr Tyr Ser Thr Arg Met Ser Gln Thr Val Gln 
    130                 135                 140                 


Arg Met Leu Val Ala Ala Ser Trp Ala Cys Ala Phe Thr Asn Ala Leu 
145                 150                 155                 160 


Thr His Thr Val Ala Met Ser Thr Leu Asn Phe Cys Gly Pro Asn Val 
                165                 170                 175     


Ile Asn His Phe Tyr Cys Asp Leu Pro Gln Leu Phe Gln Leu Ser Cys 
            180                 185                 190         


Ser Ser Thr Gln Leu Asn Glu Leu Leu Leu Phe Ala Val Gly Phe Ile 
        195                 200                 205             


Met Ala Gly Thr Pro Met Ala Leu Ile Val Ile Ser Tyr Ile His Val 
    210                 215                 220                 


Ala Ala Ala Val Leu Arg Ile Arg Ser Val Glu Gly Arg Lys Lys Ala 
225                 230                 235                 240 


Phe Ser Thr Cys Gly Ser His Leu Thr Val Val Ala Ile Phe Tyr Gly 
                245                 250                 255     


Ser Gly Ile Phe Asn Tyr Met Arg Leu Gly Ser Thr Lys Leu Ser Asp 
            260                 265                 270         


Lys Asp Lys Ala Val Gly Ile Phe Asn Thr Val Ile Asn Pro Met Leu 
        275                 280                 285             


Asn Pro Ile Ile Tyr Ser Phe Arg Asn Pro Asp Val Gln Ser Ala Ile 
    290                 295                 300                 


Trp Arg Met Leu Thr Gly Arg Arg Ser Leu Ala 
305                 310                 315 


<210>  2676
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  2676

Met Ser Leu Gln Lys Leu Met Glu Pro Glu Ala Gly Thr Asn Arg Thr 
1               5                   10                  15      


Ala Val Ala Glu Phe Ile Leu Leu Gly Leu Val Gln Thr Glu Glu Met 
            20                  25                  30          


Gln Pro Val Val Phe Val Leu Leu Leu Phe Ala Tyr Leu Val Thr Thr 
        35                  40                  45              


Gly Gly Asn Leu Ser Ile Leu Ala Ala Val Leu Val Glu Pro Lys Leu 
    50                  55                  60                  


His Ala Pro Met Tyr Phe Phe Leu Gly Asn Leu Ser Val Leu Asp Val 
65                  70                  75                  80  


Gly Cys Ile Thr Val Thr Val Pro Ala Met Leu Gly Arg Leu Leu Ser 
                85                  90                  95      


His Lys Ser Thr Ile Ser Tyr Asp Ala Cys Leu Ser Gln Leu Phe Phe 
            100                 105                 110         


Phe His Leu Leu Ala Gly Met Asp Cys Phe Leu Leu Thr Ala Met Ala 
        115                 120                 125             


Tyr Asp Arg Leu Leu Ala Ile Cys Gln Pro Leu Thr Tyr Ser Thr Arg 
    130                 135                 140                 


Met Ser Gln Thr Val Gln Arg Met Leu Val Ala Ala Ser Leu Ala Cys 
145                 150                 155                 160 


Ala Phe Thr Asn Ala Leu Thr His Thr Val Ala Met Ser Thr Leu Asn 
                165                 170                 175     


Phe Cys Gly Pro Asn Glu Val Asn His Phe Tyr Cys Asp Leu Pro Gln 
            180                 185                 190         


Leu Phe Gln Leu Ser Cys Ser Ser Thr Gln Leu Asn Glu Leu Leu Leu 
        195                 200                 205             


Phe Ala Val Gly Phe Ile Met Ala Gly Thr Pro Leu Val Leu Ile Ile 
    210                 215                 220                 


Thr Ala Tyr Ser His Val Ala Ala Ala Val Leu Arg Ile Arg Ser Val 
225                 230                 235                 240 


Glu Gly Arg Lys Lys Ala Phe Ser Thr Cys Gly Ser His Leu Thr Val 
                245                 250                 255     


Val Cys Leu Phe Phe Gly Arg Gly Ile Phe Asn Tyr Met Arg Leu Gly 
            260                 265                 270         


Ser Glu Glu Ala Ser Asp Lys Asp Lys Gly Val Gly Val Phe Asn Thr 
        275                 280                 285             


Val Ile Asn Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Pro 
    290                 295                 300                 


Asp Val Gln Gly Ala Leu Trp Gln Ile Phe Leu Gly Arg Arg Ser Leu 
305                 310                 315                 320 


Thr 
    


<210>  2677
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  2677

Met Gln Gly Ala Arg Ala Pro Arg Asp Gln Gly Arg Ser Pro Gly Arg 
1               5                   10                  15      


Met Ser Ala Leu Gly Arg Ser Ser Val Ile Leu Leu Thr Tyr Val Leu 
            20                  25                  30          


Ala Ala Thr Glu Leu Thr Cys Leu Phe Met Gln Phe Ser Ile Val Pro 
        35                  40                  45              


Tyr Leu Ser Arg Lys Leu Gly Leu Asp Ser Ile Ala Phe Gly Tyr Leu 
    50                  55                  60                  


Gln Thr Thr Phe Gly Val Leu Gln Leu Leu Gly Gly Pro Val Phe Gly 
65                  70                  75                  80  


Arg Phe Ala Asp Gln Arg Gly Ala Arg Ala Ala Leu Thr Leu Ser Phe 
                85                  90                  95      


Leu Ala Ala Leu Ala Leu Tyr Leu Leu Leu Ala Ala Ala Ser Ser Pro 
            100                 105                 110         


Ala Leu Pro Gly Val Tyr Leu Leu Phe Ala Ser Arg Leu Pro Gly Ala 
        115                 120                 125             


Leu Met His Thr Leu Pro Ala Ala Gln Met Val Ile Thr Asp Leu Ser 
    130                 135                 140                 


Ala Pro Glu Glu Arg Pro Ala Ala Leu Gly Arg Leu Gly Leu Cys Phe 
145                 150                 155                 160 


Gly Val Gly Val Ile Leu Gly Ser Leu Leu Gly Gly Thr Leu Val Ser 
                165                 170                 175     


Ala Tyr Gly Ile Gln Cys Pro Ala Ile Leu Ala Ala Leu Ala Thr Leu 
            180                 185                 190         


Leu Gly Ala Val Leu Ser Phe Thr Cys Ile Pro Ala Ser Thr Lys Gly 
        195                 200                 205             


Ala Lys Thr Asp Ala Gln Ala Pro Leu Pro Gly Gly Pro Arg Ala Ser 
    210                 215                 220                 


Val Phe Asp Leu Lys Ala Ile Ala Ser Leu Leu Arg Leu Pro Asp Val 
225                 230                 235                 240 


Pro Arg Ile Phe Leu Val Lys Val Ala Ser Asn Cys Pro Thr Gly Leu 
                245                 250                 255     


Phe Met Val Met Phe Ser Ile Ile Ser Met Asp Phe Phe Gln Leu Glu 
            260                 265                 270         


Ala Ala Gln Ala Gly Tyr Leu Met Ser Phe Phe Gly Leu Leu Gln Met 
        275                 280                 285             


Val Thr Gln Gly Leu Val Ile Gly Gln Leu Ser Ser His Phe Ser Glu 
    290                 295                 300                 


Glu Val Leu Leu Arg Ala Ser Val Leu Val Phe Ile Val Val Gly Leu 
305                 310                 315                 320 


Ala Met Ala Trp Met Ser Ser Val Phe His Phe Cys Leu Leu Val Pro 
                325                 330                 335     


Gly Leu Val Phe Ser Leu Cys Thr Leu Asn Val Val Thr Asp Ser Met 
            340                 345                 350         


Leu Ile Lys Ala Val Ser Thr Ser Asp Thr Gly Thr Met Leu Gly Leu 
        355                 360                 365             


Cys Ala Ser Val Gln Pro Leu Leu Arg Thr Leu Gly Pro Thr Val Gly 
    370                 375                 380                 


Gly Leu Leu Tyr Arg Ser Phe Gly Val Pro Val Phe Gly His Val Gln 
385                 390                 395                 400 


Val Ala Ile Asn Thr Leu Val Leu Leu Val Leu Trp Arg Lys Pro Met 
                405                 410                 415     


Pro Gln Arg Lys Asp Lys Val Arg 
            420                 


<210>  2678
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  2678

Met Ala Arg Arg Phe Gln Glu Glu Leu Ala Ala Phe Leu Phe Glu Tyr 
1               5                   10                  15      


Asp Thr Pro Arg Met Val Leu Val Arg Asn Lys Lys Val Gly Val Ile 
            20                  25                  30          


Phe Arg Leu Ile Gln Leu Val Val Leu Val Tyr Val Ile Gly Trp Val 
        35                  40                  45              


Phe Leu Tyr Glu Lys Gly Tyr Gln Thr Ser Ser Gly Leu Ile Ser Ser 
    50                  55                  60                  


Val Ser Val Lys Leu Lys Gly Leu Ala Val Thr Gln Leu Pro Gly Leu 
65                  70                  75                  80  


Gly Pro Gln Val Trp Asp Val Ala Asp Tyr Val Phe Pro Ala Gln Gly 
                85                  90                  95      


Asp Asn Ser Phe Val Val Met Thr Asn Phe Ile Val Thr Pro Lys Gln 
            100                 105                 110         


Thr Gln Gly Tyr Cys Ala Glu His Pro Glu Gly Gly Ile Cys Lys Glu 
        115                 120                 125             


Asp Ser Gly Cys Thr Pro Gly Lys Ala Lys Arg Lys Ala Gln Gly Ile 
    130                 135                 140                 


Arg Thr Gly Lys Cys Val Ala Phe Asn Asp Thr Val Lys Thr Cys Glu 
145                 150                 155                 160 


Ile Phe Gly Trp Cys Pro Val Glu Val Asp Asp Asp Ile Pro Arg Pro 
                165                 170                 175     


Ala Leu Leu Arg Glu Ala Glu Asn Phe Thr Leu Phe Ile Lys Asn Ser 
            180                 185                 190         


Ile Ser Phe Pro Arg Phe Lys Val Asn Arg Arg Asn Leu Val Glu Glu 
        195                 200                 205             


Val Asn Ala Ala His Met Lys Thr Cys Leu Phe His Lys Thr Leu His 
    210                 215                 220                 


Pro Leu Cys Pro Val Phe Gln Leu Gly Tyr Val Val Gln Glu Ser Gly 
225                 230                 235                 240 


Gln Asn Phe Ser Thr Leu Ala Glu Lys Gly Gly Val Val Gly Ile Thr 
                245                 250                 255     


Ile Asp Trp His Cys Asp Leu Asp Trp His Val Arg His Cys Arg Pro 
            260                 265                 270         


Ile Tyr Glu Phe His Gly Leu Tyr Glu Glu Lys Asn Leu Ser Pro Gly 
        275                 280                 285             


Phe Asn Phe Arg Phe Ala Arg His Phe Val Glu Asn Gly Thr Asn Tyr 
    290                 295                 300                 


Arg His Leu Phe Lys Val Phe Gly Ile Arg Phe Asp Ile Leu Val Asp 
305                 310                 315                 320 


Gly Lys Ala Gly Lys Phe Asp Ile Ile Pro Thr Met Thr Thr Ile Gly 
                325                 330                 335     


Ser Gly Ile Gly Ile Phe Gly Val Ala Thr Val Leu Cys Asp Leu Leu 
            340                 345                 350         


Leu Leu His Ile Leu Pro Lys Arg His Tyr Tyr Lys Gln Lys Lys Phe 
        355                 360                 365             


Lys Tyr Ala Glu Asp Met Gly Pro Gly Ala Ala Glu Arg Asp Leu Ala 
    370                 375                 380                 


Ala Thr Ser Ser Thr Leu Gly Leu Gln Glu Asn Met Arg Thr Ser 
385                 390                 395                 


<210>  2679
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  2679

Met Ala Gly Cys Cys Ala Ala Leu Ala Ala Phe Leu Phe Glu Tyr Asp 
1               5                   10                  15      


Thr Pro Arg Ile Val Leu Ile Arg Ser Arg Lys Val Gly Leu Met Asn 
            20                  25                  30          


Arg Ala Val Gln Leu Leu Ile Leu Ala Tyr Val Ile Gly Trp Val Phe 
        35                  40                  45              


Val Trp Glu Lys Gly Tyr Gln Glu Thr Asp Ser Val Val Ser Ser Val 
    50                  55                  60                  


Thr Thr Lys Val Lys Gly Val Ala Val Thr Asn Thr Ser Lys Leu Gly 
65                  70                  75                  80  


Phe Arg Ile Trp Asp Val Ala Asp Tyr Val Ile Pro Ala Gln Glu Glu 
                85                  90                  95      


Asn Ser Leu Phe Val Met Thr Asn Val Ile Leu Thr Met Asn Gln Thr 
            100                 105                 110         


Gln Gly Leu Cys Pro Glu Ile Pro Asp Ala Thr Thr Val Cys Lys Ser 
        115                 120                 125             


Asp Ala Ser Cys Thr Ala Gly Ser Ala Gly Thr His Ser Asn Gly Val 
    130                 135                 140                 


Ser Thr Gly Arg Cys Val Ala Phe Asn Gly Ser Val Lys Thr Cys Glu 
145                 150                 155                 160 


Val Ala Ala Trp Cys Pro Val Glu Asp Asp Thr His Val Pro Gln Pro 
                165                 170                 175     


Ala Phe Leu Lys Ala Ala Glu Asn Phe Thr Leu Leu Val Lys Asn Asn 
            180                 185                 190         


Ile Trp Tyr Pro Lys Phe Asn Phe Ser Lys Arg Asn Ile Leu Pro Asn 
        195                 200                 205             


Ile Thr Thr Thr Tyr Leu Lys Ser Cys Ile Tyr Asp Ala Lys Thr Asp 
    210                 215                 220                 


Pro Phe Cys Pro Ile Phe Arg Leu Gly Lys Ile Val Glu Asn Ala Gly 
225                 230                 235                 240 


His Ser Phe Gln Asp Met Ala Val Glu Gly Gly Ile Met Gly Ile Gln 
                245                 250                 255     


Val Asn Trp Asp Cys Asn Leu Asp Arg Ala Ala Ser Leu Cys Leu Pro 
            260                 265                 270         


Arg Tyr Ser Phe Arg Arg Leu Asp Thr Arg Asp Val Glu His Asn Val 
        275                 280                 285             


Ser Pro Gly Tyr Asn Phe Arg Phe Ala Lys Tyr Tyr Arg Asp Leu Ala 
    290                 295                 300                 


Gly Asn Glu Gln Arg Thr Leu Ile Lys Ala Tyr Gly Ile Arg Phe Asp 
305                 310                 315                 320 


Ile Ile Val Phe Gly Lys Ala Gly Lys Phe Asp Ile Ile Pro Thr Met 
                325                 330                 335     


Ile Asn Ile Gly Ser Gly Leu Ala Leu Leu Gly Met Ala Thr Val Leu 
            340                 345                 350         


Cys Asp Ile Ile Val Leu Tyr Cys Met Lys Lys Arg Leu Tyr Tyr Arg 
        355                 360                 365             


Glu Lys Lys Tyr Lys Tyr Val Glu Asp Tyr Glu Gln Gly Leu Ala Ser 
    370                 375                 380                 


Glu Leu Asp Gln 
385             


<210>  2680
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  2680

Met Gly Gln Ala Gly Cys Lys Gly Leu Cys Leu Ser Leu Phe Asp Tyr 
1               5                   10                  15      


Lys Thr Glu Lys Tyr Val Ile Ala Lys Asn Lys Lys Val Gly Leu Leu 
            20                  25                  30          


Tyr Arg Leu Leu Gln Ala Ser Ile Leu Ala Tyr Leu Val Val Trp Val 
        35                  40                  45              


Phe Leu Ile Lys Lys Gly Tyr Gln Asp Val Asp Thr Ser Leu Gln Ser 
    50                  55                  60                  


Ala Val Ile Thr Lys Val Lys Gly Val Ala Phe Thr Asn Thr Ser Asp 
65                  70                  75                  80  


Leu Gly Gln Arg Ile Trp Asp Val Ala Asp Tyr Val Ile Pro Ala Gln 
                85                  90                  95      


Gly Glu Asn Val Phe Phe Val Val Thr Asn Leu Ile Val Thr Pro Asn 
            100                 105                 110         


Gln Arg Gln Asn Val Cys Ala Glu Asn Glu Gly Ile Pro Asp Gly Ala 
        115                 120                 125             


Cys Ser Lys Asp Ser Asp Cys His Ala Gly Glu Ala Val Thr Ala Gly 
    130                 135                 140                 


Asn Gly Val Lys Thr Gly Arg Cys Leu Arg Arg Glu Asn Leu Ala Arg 
145                 150                 155                 160 


Gly Thr Cys Glu Ile Phe Ala Trp Cys Pro Leu Glu Thr Ser Ser Arg 
                165                 170                 175     


Pro Glu Glu Pro Phe Leu Lys Glu Ala Glu Asp Phe Thr Ile Phe Ile 
            180                 185                 190         


Lys Asn His Ile Arg Phe Pro Lys Phe Asn Phe Ser Lys Ser Asn Val 
        195                 200                 205             


Met Asp Val Lys Asp Arg Ser Phe Leu Lys Ser Cys His Phe Gly Pro 
    210                 215                 220                 


Lys Asn His Tyr Cys Pro Ile Phe Arg Leu Gly Ser Val Ile Arg Trp 
225                 230                 235                 240 


Ala Gly Ser Asp Phe Gln Asp Ile Ala Leu Glu Gly Gly Val Ile Gly 
                245                 250                 255     


Ile Asn Ile Glu Trp Asn Cys Asp Leu Asp Lys Ala Ala Ser Glu Cys 
            260                 265                 270         


His Pro His Tyr Ser Phe Ser Arg Leu Asp Asn Lys Leu Ser Lys Ser 
        275                 280                 285             


Val Ser Ser Gly Tyr Asn Phe Arg Phe Ala Arg Tyr Tyr Arg Asp Ala 
    290                 295                 300                 


Ala Gly Val Glu Phe Arg Thr Leu Met Lys Ala Tyr Gly Ile Arg Phe 
305                 310                 315                 320 


Asp Val Met Val Asn Gly Lys Gly Ala Phe Phe Cys Asp Leu Val Leu 
                325                 330                 335     


Ile Tyr Leu Ile Lys Lys Arg Glu Phe Tyr Arg Asp Lys Lys Tyr Glu 
            340                 345                 350         


Glu Val Arg Gly Leu Glu Asp Ser Ser Gln Glu Ala Glu Asp Glu Ala 
        355                 360                 365             


Ser Gly Leu Gly Leu Ser Glu Gln Leu Thr Ser Gly Pro Gly Leu Leu 
    370                 375                 380                 


Gly Met Pro Glu Gln Gln Glu Leu Gln Glu Pro Pro Glu Ala Lys Arg 
385                 390                 395                 400 


Gly Ser Ser Ser Gln Lys Gly Asn Gly Ser Val Cys Pro Gln Leu Leu 
                405                 410                 415     


Glu Pro His Arg Ser Thr 
            420         


<210>  2681
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  2681

Met Pro Ala Cys Cys Ser Cys Ser Asp Val Phe Gln Tyr Glu Thr Asn 
1               5                   10                  15      


Lys Val Thr Arg Ile Gln Ser Met Asn Tyr Gly Thr Ile Lys Trp Phe 
            20                  25                  30          


Phe His Val Ile Ile Phe Ser Tyr Val Cys Phe Ala Leu Val Ser Asp 
        35                  40                  45              


Lys Leu Tyr Gln Arg Lys Glu Pro Val Ile Ser Ser Val His Thr Lys 
    50                  55                  60                  


Val Lys Gly Ile Ala Glu Val Lys Glu Glu Ile Val Glu Asn Gly Val 
65                  70                  75                  80  


Lys Lys Leu Val His Ser Val Phe Asp Thr Ala Asp Tyr Thr Phe Pro 
                85                  90                  95      


Leu Gln Gly Asn Ser Phe Phe Val Met Thr Asn Phe Leu Lys Thr Glu 
            100                 105                 110         


Gly Gln Glu Gln Arg Leu Cys Pro Glu Tyr Pro Thr Arg Arg Thr Leu 
        115                 120                 125             


Cys Ser Ser Asp Arg Gly Cys Lys Lys Gly Trp Met Asp Pro Gln Ser 
    130                 135                 140                 


Lys Gly Ile Gln Thr Gly Arg Cys Val Val Tyr Glu Gly Asn Gln Lys 
145                 150                 155                 160 


Thr Cys Glu Val Ser Ala Trp Cys Pro Ile Glu Ala Val Glu Glu Ala 
                165                 170                 175     


Pro Arg Pro Ala Leu Leu Asn Ser Ala Glu Asn Phe Thr Val Leu Ile 
            180                 185                 190         


Lys Asn Asn Ile Asp Phe Pro Gly His Asn Tyr Thr Thr Arg Asn Ile 
        195                 200                 205             


Leu Pro Gly Leu Asn Ile Thr Cys Thr Phe His Lys Thr Gln Asn Pro 
    210                 215                 220                 


Gln Cys Pro Ile Phe Arg Leu Gly Asp Ile Phe Arg Glu Thr Gly Asp 
225                 230                 235                 240 


Asn Phe Ser Asp Val Ala Ile Gln Gly Gly Ile Met Gly Ile Glu Ile 
                245                 250                 255     


Tyr Trp Asp Cys Asn Leu Asp Arg Trp Phe His His Cys Arg Pro Lys 
            260                 265                 270         


Tyr Ser Phe Arg Arg Leu Asp Asp Lys Thr Thr Asn Val Ser Leu Tyr 
        275                 280                 285             


Pro Gly Tyr Asn Phe Arg Tyr Ala Lys Tyr Tyr Lys Glu Asn Asn Val 
    290                 295                 300                 


Glu Lys Arg Thr Leu Ile Lys Val Phe Gly Ile Arg Phe Asp Ile Leu 
305                 310                 315                 320 


Val Phe Gly Thr Gly Gly Lys Phe Asp Ile Ile Gln Leu Val Val Tyr 
                325                 330                 335     


Ile Gly Ser Thr Leu Ser Tyr Phe Gly Leu Ala Ala Val Phe Ile Asp 
            340                 345                 350         


Phe Leu Ile Asp Thr Tyr Ser Ser Asn Cys Cys Arg Ser His Ile Tyr 
        355                 360                 365             


Pro Trp Cys Lys Cys Cys Gln Pro Cys Val Val Asn Glu Tyr Tyr Tyr 
    370                 375                 380                 


Arg Lys Lys Cys Glu Ser Ile Val Glu Pro Lys Pro Thr Leu Lys Tyr 
385                 390                 395                 400 


Val Ser Phe Val Asp Glu Ser His Ile Arg Met Val Asn Gln Gln Leu 
                405                 410                 415     


Leu Gly Arg Ser Leu Gln Asp Val Lys Gly Gln Glu Val Pro Arg Pro 
            420                 425                 430         


Ala Met Asp Phe Thr Asp Leu Ser Arg Leu Pro Leu Ala Leu His Asp 
        435                 440                 445             


Thr Pro Pro Ile Pro Gly Gln Pro Glu Glu Ile Gln Leu Leu Arg Lys 
    450                 455                 460                 


Glu Ala Thr Pro Arg Ser Arg Asp Ser Pro Val Trp Cys Gln Cys Gly 
465                 470                 475                 480 


Ser Cys Leu Pro Ser Gln Leu Pro Glu Ser His Arg Cys Leu Glu Glu 
                485                 490                 495     


Leu Cys Cys Arg Lys Lys Pro Gly Ala Cys Ile Thr Thr Ser Glu Leu 
            500                 505                 510         


Phe Arg Lys Leu Val Leu Ser Arg His Val Leu Gln Phe Leu Leu Leu 
        515                 520                 525             


Tyr Gln Glu Pro Leu Leu Ala Leu Asp Val Asp Ser Thr Asn Ser Arg 
    530                 535                 540                 


Leu Arg His Cys Ala Tyr Arg Cys Tyr Ala Thr Trp Arg Phe Gly Ser 
545                 550                 555                 560 


Gln Asp Met Ala Asp Phe Ala Ile Leu Pro Ser Cys Cys Arg Trp Arg 
                565                 570                 575     


Ile Arg Lys Glu Phe Pro Lys Ser Glu Gly Gln Tyr Ser Gly Phe Lys 
            580                 585                 590         


Ser Pro Tyr 
        595 


<210>  2682
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  2682

Met Thr Glu Val Leu Trp Pro Ala Val Pro Asn Gly Thr Asp Ala Ala 
1               5                   10                  15      


Phe Leu Ala Gly Pro Gly Ser Ser Trp Gly Asn Ser Thr Val Ala Ser 
            20                  25                  30          


Thr Ala Ala Val Ser Ser Ser Phe Lys Cys Ala Leu Thr Lys Thr Gly 
        35                  40                  45              


Phe Gln Phe Tyr Tyr Leu Pro Ala Val Tyr Ile Leu Val Phe Ile Ile 
    50                  55                  60                  


Gly Phe Leu Gly Asn Ser Val Ala Ile Trp Met Phe Val Phe His Met 
65                  70                  75                  80  


Lys Pro Trp Ser Gly Ile Ser Val Tyr Met Phe Asn Leu Ala Leu Ala 
                85                  90                  95      


Asp Phe Leu Tyr Val Leu Thr Leu Pro Ala Leu Ile Phe Tyr Tyr Phe 
            100                 105                 110         


Asn Lys Thr Asp Trp Ile Phe Gly Asp Ala Met Cys Lys Leu Gln Arg 
        115                 120                 125             


Phe Ile Phe His Val Asn Leu Tyr Gly Ser Ile Leu Phe Leu Thr Cys 
    130                 135                 140                 


Ile Ser Ala His Arg Tyr Ser Gly Val Val Tyr Pro Leu Lys Ser Leu 
145                 150                 155                 160 


Gly Arg Leu Lys Lys Lys Asn Ala Ile Cys Ile Ser Val Leu Val Trp 
                165                 170                 175     


Leu Ile Val Val Val Ala Ile Ser Pro Ile Leu Phe Tyr Ser Gly Thr 
            180                 185                 190         


Gly Val Arg Lys Asn Lys Thr Ile Thr Cys Tyr Asp Thr Thr Ser Asp 
        195                 200                 205             


Glu Tyr Leu Arg Ser Tyr Phe Ile Tyr Ser Met Cys Thr Thr Val Ala 
    210                 215                 220                 


Met Phe Cys Val Pro Leu Val Leu Ile Leu Gly Cys Tyr Gly Leu Ile 
225                 230                 235                 240 


Val Arg Ala Leu Ile Tyr Lys Asp Leu Asp Asn Ser Pro Leu Arg Arg 
                245                 250                 255     


Lys Ser Ile Tyr Leu Val Ile Ile Val Leu Thr Val Phe Ala Val Ser 
            260                 265                 270         


Tyr Ile Pro Phe His Val Met Lys Thr Met Asn Leu Arg Ala Arg Leu 
        275                 280                 285             


Asp Phe Gln Thr Pro Ala Met Cys Ala Phe Asn Asp Arg Val Tyr Ala 
    290                 295                 300                 


Thr Tyr Gln Val Thr Arg Gly Leu Ala Ser Leu Asn Ser Cys Val Asp 
305                 310                 315                 320 


Pro Ile Leu Tyr Phe Leu Ala Gly Asp Thr Phe Arg Arg Arg Leu Ser 
                325                 330                 335     


Arg Ala Thr Arg Lys Ala Ser Arg Arg Ser Glu Ala Asn Leu Gln Ser 
            340                 345                 350         


Lys Ser Glu Asp Met Thr Leu Asn Ile Leu Pro Glu Phe Lys Gln Asn 
        355                 360                 365             


Gly Asp Thr Ser Leu 
    370             


<210>  2683
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  2683

Met Ala Ala Asp Leu Gly Pro Trp Asn Asp Thr Ile Asn Gly Thr Trp 
1               5                   10                  15      


Asp Gly Asp Glu Leu Gly Tyr Arg Cys Arg Phe Asn Glu Asp Phe Lys 
            20                  25                  30          


Tyr Val Leu Leu Pro Val Ser Tyr Gly Val Val Cys Val Leu Gly Leu 
        35                  40                  45              


Cys Leu Asn Ala Val Ala Leu Tyr Ile Phe Leu Cys Arg Leu Lys Thr 
    50                  55                  60                  


Trp Asn Ala Ser Thr Thr Tyr Met Phe His Leu Ala Val Ser Asp Ala 
65                  70                  75                  80  


Leu Tyr Ala Ala Ser Leu Pro Leu Leu Val Tyr Tyr Tyr Ala Arg Gly 
                85                  90                  95      


Asp His Trp Pro Phe Ser Thr Val Leu Cys Lys Leu Val Arg Phe Leu 
            100                 105                 110         


Phe Tyr Thr Asn Leu Tyr Cys Ser Ile Leu Phe Leu Thr Cys Ile Ser 
        115                 120                 125             


Val His Arg Cys Leu Gly Val Leu Arg Pro Leu Arg Ser Leu Arg Trp 
    130                 135                 140                 


Gly Arg Ala Arg Tyr Ala Arg Arg Val Ala Gly Ala Val Trp Val Leu 
145                 150                 155                 160 


Val Leu Ala Cys Gln Ala Pro Val Leu Tyr Phe Val Thr Thr Ser Ala 
                165                 170                 175     


Arg Gly Gly Arg Val Thr Cys His Asp Thr Ser Ala Pro Glu Leu Phe 
            180                 185                 190         


Ser Arg Phe Val Ala Tyr Ser Ser Val Met Leu Gly Leu Leu Phe Ala 
        195                 200                 205             


Val Pro Phe Ala Val Ile Leu Val Cys Tyr Val Leu Met Ala Arg Arg 
    210                 215                 220                 


Leu Leu Lys Pro Ala Tyr Gly Thr Ser Gly Gly Leu Pro Arg Ala Lys 
225                 230                 235                 240 


Arg Lys Ser Val Arg Thr Ile Ala Val Val Leu Ala Val Phe Ala Leu 
                245                 250                 255     


Cys Phe Leu Pro Phe His Val Thr Arg Thr Leu Tyr Tyr Ser Phe Arg 
            260                 265                 270         


Ser Leu Asp Leu Ser Cys His Thr Leu Asn Ala Ile Asn Met Ala Tyr 
        275                 280                 285             


Lys Val Thr Arg Pro Leu Ala Ser Ala Asn Ser Cys Leu Asp Pro Val 
    290                 295                 300                 


Leu Tyr Phe Leu Ala Gly Gln Arg Leu Val Arg Phe Ala Arg Asp Ala 
305                 310                 315                 320 


Lys Pro Pro Thr Gly Pro Ser Pro Ala Thr Pro Ala Arg Arg Arg Leu 
                325                 330                 335     


Gly Leu Arg Arg Ser Asp Arg Thr Asp Met Gln Arg Ile Glu Asp Val 
            340                 345                 350         


Leu Gly Ser Ser Glu Asp Ser Arg Arg Thr Glu Ser Thr Pro Ala Gly 
        355                 360                 365             


Ser Glu Asn Thr Lys Asp Ile Arg Leu 
    370                 375         


<210>  2684
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  2684

Met Ala Ser Thr Glu Ser Ser Leu Leu Arg Ser Leu Gly Leu Ser Pro 
1               5                   10                  15      


Gly Pro Gly Ser Ser Glu Val Glu Leu Asp Cys Trp Phe Asp Glu Asp 
            20                  25                  30          


Phe Lys Phe Ile Leu Leu Pro Val Ser Tyr Ala Val Val Phe Val Leu 
        35                  40                  45              


Gly Leu Gly Leu Asn Ala Pro Thr Leu Trp Leu Phe Ile Phe Arg Leu 
    50                  55                  60                  


Arg Pro Trp Asp Ala Thr Ala Thr Tyr Met Phe His Leu Ala Leu Ser 
65                  70                  75                  80  


Asp Thr Leu Tyr Val Leu Ser Leu Pro Thr Leu Ile Tyr Tyr Tyr Ala 
                85                  90                  95      


Ala His Asn His Trp Pro Phe Gly Thr Glu Ile Cys Lys Phe Val Arg 
            100                 105                 110         


Phe Leu Phe Tyr Trp Asn Leu Tyr Cys Ser Val Leu Phe Leu Thr Cys 
        115                 120                 125             


Ile Ser Val His Arg Tyr Leu Gly Ile Cys His Pro Leu Arg Ala Leu 
    130                 135                 140                 


Arg Trp Gly Arg Pro Arg Leu Ala Gly Leu Leu Cys Leu Ala Val Trp 
145                 150                 155                 160 


Leu Val Val Ala Gly Cys Leu Val Pro Asn Leu Phe Phe Val Thr Thr 
                165                 170                 175     


Ser Asn Lys Gly Thr Thr Val Leu Cys His Asp Thr Thr Arg Pro Glu 
            180                 185                 190         


Glu Phe Asp His Tyr Val His Phe Ser Ser Ala Val Met Gly Leu Leu 
        195                 200                 205             


Phe Gly Val Pro Cys Leu Val Thr Leu Val Cys Tyr Gly Leu Met Ala 
    210                 215                 220                 


Arg Arg Leu Tyr Gln Pro Leu Pro Gly Ser Ala Gln Ser Ser Ser Arg 
225                 230                 235                 240 


Leu Arg Ser Leu Arg Thr Ile Ala Val Val Leu Thr Val Phe Ala Val 
                245                 250                 255     


Cys Phe Val Pro Phe His Ile Thr Arg Thr Ile Tyr Tyr Leu Ala Arg 
            260                 265                 270         


Leu Leu Glu Ala Asp Cys Arg Val Leu Asn Ile Val Asn Val Val Tyr 
        275                 280                 285             


Lys Val Thr Arg Pro Leu Ala Ser Ala Asn Ser Cys Leu Asp Pro Val 
    290                 295                 300                 


Leu Tyr Leu Leu Thr Gly Asp Lys Tyr Arg Arg Gln Leu Arg Gln Leu 
305                 310                 315                 320 


Cys Gly Gly Gly Lys Pro Gln Pro Arg Thr Ala Ala Ser Ser Leu Ala 
                325                 330                 335     


Leu Val Ser Leu Pro Glu Asp Ser Ser Cys Arg Trp Ala Ala Thr Pro 
            340                 345                 350         


Gln Asp Ser Ser Cys Ser Thr Pro Arg Ala Asp Arg Leu 
        355                 360                 365 


<210>  2685
<211>  794
<212>  PRT
<213>  Homo sapiens

<400>  2685

Met Glu Leu Arg Pro Trp Leu Leu Trp Val Val Ala Ala Thr Gly Thr 
1               5                   10                  15      


Leu Val Leu Leu Ala Ala Asp Ala Gln Gly Gln Lys Val Phe Thr Asn 
            20                  25                  30          


Thr Trp Ala Val Arg Ile Pro Gly Gly Pro Ala Val Ala Asn Ser Val 
        35                  40                  45              


Ala Arg Lys His Gly Phe Leu Asn Leu Gly Gln Ile Phe Gly Asp Tyr 
    50                  55                  60                  


Tyr His Phe Trp His Arg Gly Val Thr Lys Arg Ser Leu Ser Pro His 
65                  70                  75                  80  


Arg Pro Arg His Ser Arg Leu Gln Arg Glu Pro Gln Val Gln Trp Leu 
                85                  90                  95      


Glu Gln Gln Val Ala Lys Arg Arg Thr Lys Arg Asp Val Tyr Gln Glu 
            100                 105                 110         


Pro Thr Asp Pro Lys Phe Pro Gln Gln Trp Tyr Leu Ser Gly Val Thr 
        115                 120                 125             


Gln Arg Asp Leu Asn Val Lys Ala Ala Trp Ala Gln Gly Tyr Thr Gly 
    130                 135                 140                 


His Gly Ile Val Val Ser Ile Leu Asp Asp Gly Ile Glu Lys Asn His 
145                 150                 155                 160 


Pro Asp Leu Ala Gly Asn Tyr Asp Pro Gly Ala Ser Phe Asp Val Asn 
                165                 170                 175     


Asp Gln Asp Pro Asp Pro Gln Pro Arg Tyr Thr Gln Met Asn Asp Asn 
            180                 185                 190         


Arg His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala Val Ala Asn Asn 
        195                 200                 205             


Gly Val Cys Gly Val Gly Val Ala Tyr Asn Ala Arg Ile Gly Gly Val 
    210                 215                 220                 


Arg Met Leu Asp Gly Glu Val Thr Asp Ala Val Glu Ala Arg Ser Leu 
225                 230                 235                 240 


Gly Leu Asn Pro Asn His Ile His Ile Tyr Ser Ala Ser Trp Gly Pro 
                245                 250                 255     


Glu Asp Asp Gly Lys Thr Val Asp Gly Pro Ala Arg Leu Ala Glu Glu 
            260                 265                 270         


Ala Phe Phe Arg Gly Val Ser Gln Gly Arg Gly Gly Leu Gly Ser Ile 
        275                 280                 285             


Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Glu His Asp Ser Cys Asn 
    290                 295                 300                 


Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Leu Ser Ile Ser Ser Ala 
305                 310                 315                 320 


Thr Gln Phe Gly Asn Val Pro Trp Tyr Ser Glu Ala Cys Ser Ser Thr 
                325                 330                 335     


Leu Ala Thr Thr Tyr Ser Ser Gly Asn Gln Asn Glu Lys Gln Ile Val 
            340                 345                 350         


Thr Thr Asp Leu Arg Gln Lys Cys Thr Glu Ser His Thr Gly Thr Ser 
        355                 360                 365             


Ala Ser Ala Pro Leu Ala Ala Gly Ile Ile Ala Leu Thr Leu Glu Ala 
    370                 375                 380                 


Asn Lys Asn Leu Thr Trp Arg Asp Met Gln His Leu Val Val Gln Thr 
385                 390                 395                 400 


Ser Lys Pro Ala His Leu Asn Ala Asn Asp Trp Ala Thr Asn Gly Val 
                405                 410                 415     


Gly Arg Lys Val Ser His Ser Tyr Gly Tyr Gly Leu Leu Asp Ala Gly 
            420                 425                 430         


Ala Met Val Ala Leu Ala Gln Asn Trp Thr Thr Val Ala Pro Gln Arg 
        435                 440                 445             


Lys Cys Ile Ile Asp Ile Leu Thr Glu Pro Lys Asp Ile Gly Lys Arg 
    450                 455                 460                 


Leu Glu Val Arg Lys Thr Val Thr Ala Cys Leu Gly Glu Pro Asn His 
465                 470                 475                 480 


Ile Thr Arg Leu Glu His Ala Gln Ala Arg Leu Thr Leu Ser Tyr Asn 
                485                 490                 495     


Arg Arg Gly Asp Leu Ala Ile His Leu Val Ser Pro Met Gly Thr Arg 
            500                 505                 510         


Ser Thr Leu Leu Ala Ala Arg Pro His Asp Tyr Ser Ala Asp Gly Phe 
        515                 520                 525             


Asn Asp Trp Ala Phe Met Thr Thr His Ser Trp Asp Glu Asp Pro Ser 
    530                 535                 540                 


Gly Glu Trp Val Leu Glu Ile Glu Asn Thr Ser Glu Ala Asn Asn Tyr 
545                 550                 555                 560 


Gly Thr Leu Thr Lys Phe Thr Leu Val Leu Tyr Gly Thr Ala Pro Glu 
                565                 570                 575     


Gly Leu Pro Val Pro Pro Glu Ser Ser Gly Cys Lys Thr Leu Thr Ser 
            580                 585                 590         


Ser Gln Ala Cys Val Val Cys Glu Glu Gly Phe Ser Leu His Gln Lys 
        595                 600                 605             


Ser Cys Val Gln His Cys Pro Pro Gly Phe Ala Pro Gln Val Leu Asp 
    610                 615                 620                 


Thr His Tyr Ser Thr Glu Asn Asp Val Glu Thr Ile Arg Ala Ser Val 
625                 630                 635                 640 


Cys Ala Pro Cys His Ala Ser Cys Ala Thr Cys Gln Gly Pro Ala Leu 
                645                 650                 655     


Thr Asp Cys Leu Ser Cys Pro Ser His Ala Ser Leu Asp Pro Val Glu 
            660                 665                 670         


Gln Thr Cys Ser Arg Gln Ser Gln Ser Ser Arg Glu Ser Pro Pro Gln 
        675                 680                 685             


Gln Gln Pro Pro Arg Leu Pro Pro Glu Val Glu Ala Gly Gln Arg Leu 
    690                 695                 700                 


Arg Ala Gly Leu Leu Pro Ser His Leu Pro Glu Val Val Ala Gly Leu 
705                 710                 715                 720 


Ser Cys Ala Phe Ile Val Leu Val Phe Val Thr Val Phe Leu Val Leu 
                725                 730                 735     


Gln Leu Arg Ser Gly Phe Ser Phe Arg Gly Val Lys Val Tyr Thr Met 
            740                 745                 750         


Asp Arg Gly Leu Ile Ser Tyr Lys Gly Leu Pro Pro Glu Ala Trp Gln 
        755                 760                 765             


Glu Glu Cys Pro Ser Asp Ser Glu Glu Asp Glu Gly Arg Gly Glu Arg 
    770                 775                 780                 


Thr Ala Phe Ile Lys Asp Gln Ser Ala Leu 
785                 790                 


<210>  2686
<211>  1060
<212>  PRT
<213>  Homo sapiens

<400>  2686

Met Asp Ser Gly Ala Gly Gly Arg Arg Cys Pro Glu Ala Ala Leu Leu 
1               5                   10                  15      


Ile Leu Gly Pro Pro Arg Met Glu His Leu Arg His Ser Pro Gly Pro 
            20                  25                  30          


Gly Gly Gln Arg Leu Leu Leu Pro Ser Met Leu Leu Ala Leu Leu Leu 
        35                  40                  45              


Leu Leu Ala Pro Ser Pro Gly His Ala Thr Arg Val Val Tyr Lys Val 
    50                  55                  60                  


Pro Glu Glu Gln Pro Pro Asn Thr Leu Ile Gly Ser Leu Ala Ala Asp 
65                  70                  75                  80  


Tyr Gly Phe Pro Asp Val Gly His Leu Tyr Lys Leu Glu Val Gly Ala 
                85                  90                  95      


Pro Tyr Leu Arg Val Asp Gly Lys Thr Gly Asp Ile Phe Thr Thr Glu 
            100                 105                 110         


Thr Ser Ile Asp Arg Glu Gly Leu Arg Glu Cys Gln Asn Gln Leu Pro 
        115                 120                 125             


Gly Asp Pro Cys Ile Leu Glu Phe Glu Val Ser Ile Thr Asp Leu Val 
    130                 135                 140                 


Gln Asn Gly Ser Pro Arg Leu Leu Glu Gly Gln Ile Glu Val Gln Asp 
145                 150                 155                 160 


Ile Asn Asp Asn Thr Pro Asn Phe Ala Ser Pro Val Ile Thr Leu Ala 
                165                 170                 175     


Ile Pro Glu Asn Thr Asn Ile Gly Ser Leu Phe Pro Ile Pro Leu Ala 
            180                 185                 190         


Ser Asp Arg Asp Ala Gly Pro Asn Gly Val Ala Ser Tyr Glu Leu Gln 
        195                 200                 205             


Ala Gly Pro Glu Ala Gln Glu Leu Phe Gly Leu Gln Val Ala Glu Asp 
    210                 215                 220                 


Gln Glu Glu Lys Gln Pro Gln Leu Ile Val Met Gly Asn Leu Asp Arg 
225                 230                 235                 240 


Glu Arg Trp Asp Ser Tyr Asp Leu Thr Ile Lys Val Gln Asp Gly Gly 
                245                 250                 255     


Ser Pro Pro Arg Ala Ser Ser Ala Leu Leu Arg Val Thr Val Leu Asp 
            260                 265                 270         


Thr Asn Asp Asn Ala Pro Lys Phe Glu Arg Pro Ser Tyr Glu Ala Glu 
        275                 280                 285             


Leu Ser Glu Asn Ser Pro Ile Gly His Ser Val Ile Gln Val Lys Ala 
    290                 295                 300                 


Asn Asp Ser Asp Gln Gly Ala Asn Ala Glu Ile Glu Tyr Thr Phe His 
305                 310                 315                 320 


Gln Ala Pro Glu Val Val Arg Arg Leu Leu Arg Leu Asp Arg Asn Thr 
                325                 330                 335     


Gly Leu Ile Thr Val Gln Gly Pro Val Asp Arg Glu Asp Leu Ser Thr 
            340                 345                 350         


Leu Arg Phe Ser Val Leu Ala Lys Asp Arg Gly Thr Asn Pro Lys Ser 
        355                 360                 365             


Ala Arg Ala Gln Val Val Val Thr Val Lys Asp Met Asn Asp Asn Ala 
    370                 375                 380                 


Pro Thr Ile Glu Ile Arg Gly Ile Gly Leu Val Thr His Gln Asp Gly 
385                 390                 395                 400 


Met Ala Asn Ile Ser Glu Asp Val Ala Glu Glu Thr Ala Val Ala Leu 
                405                 410                 415     


Val Gln Val Ser Asp Arg Asp Glu Gly Glu Asn Ala Ala Val Thr Cys 
            420                 425                 430         


Val Val Ala Gly Asp Val Pro Phe Gln Leu Arg Gln Ala Ser Glu Thr 
        435                 440                 445             


Gly Ser Asp Ser Lys Lys Lys Tyr Phe Leu Gln Thr Thr Thr Pro Leu 
    450                 455                 460                 


Asp Tyr Glu Lys Val Lys Asp Tyr Thr Ile Glu Ile Val Ala Val Asp 
465                 470                 475                 480 


Ser Gly Asn Pro Pro Leu Ser Ser Thr Asn Ser Leu Lys Val Gln Val 
                485                 490                 495     


Val Asp Val Asn Asp Asn Ala Pro Val Phe Thr Gln Ser Val Thr Glu 
            500                 505                 510         


Val Ala Phe Pro Glu Asn Asn Lys Pro Gly Glu Val Ile Ala Glu Ile 
        515                 520                 525             


Thr Ala Ser Asp Ala Asp Ser Gly Ser Asn Ala Glu Leu Val Tyr Ser 
    530                 535                 540                 


Leu Glu Pro Glu Pro Ala Ala Lys Gly Leu Phe Thr Ile Ser Pro Glu 
545                 550                 555                 560 


Thr Gly Glu Ile Gln Val Lys Thr Ser Leu Asp Arg Glu Gln Arg Glu 
                565                 570                 575     


Ser Tyr Glu Leu Lys Val Val Ala Ala Asp Arg Gly Ser Pro Ser Leu 
            580                 585                 590         


Gln Gly Thr Ala Thr Val Leu Val Asn Val Leu Asp Cys Asn Asp Asn 
        595                 600                 605             


Asp Pro Lys Phe Met Leu Ser Gly Tyr Asn Phe Ser Val Met Glu Asn 
    610                 615                 620                 


Met Pro Ala Leu Ser Pro Val Gly Met Val Thr Val Ile Asp Gly Asp 
625                 630                 635                 640 


Lys Gly Glu Asn Ala Gln Val Gln Leu Ser Val Glu Gln Asp Asn Gly 
                645                 650                 655     


Asp Phe Val Ile Gln Asn Gly Thr Gly Thr Ile Leu Ser Ser Leu Ser 
            660                 665                 670         


Phe Asp Arg Glu Gln Gln Ser Thr Tyr Thr Phe Gln Leu Lys Ala Val 
        675                 680                 685             


Asp Gly Gly Val Pro Pro Arg Ser Ala Tyr Val Gly Val Thr Ile Asn 
    690                 695                 700                 


Val Leu Asp Glu Asn Asp Asn Ala Pro Tyr Ile Thr Ala Pro Ser Asn 
705                 710                 715                 720 


Thr Ser His Lys Leu Leu Thr Pro Gln Thr Arg Leu Gly Glu Thr Val 
                725                 730                 735     


Ser Gln Val Ala Ala Glu Asp Phe Asp Ser Gly Val Asn Ala Glu Leu 
            740                 745                 750         


Ile Tyr Ser Ile Ala Gly Gly Asn Pro Tyr Gly Leu Phe Gln Ile Gly 
        755                 760                 765             


Ser His Ser Gly Ala Ile Thr Leu Glu Lys Glu Ile Glu Arg Arg His 
    770                 775                 780                 


His Gly Leu His Arg Leu Val Val Lys Val Ser Asp Arg Gly Lys Pro 
785                 790                 795                 800 


Pro Arg Tyr Gly Thr Ala Leu Val His Leu Tyr Val Asn Glu Thr Leu 
                805                 810                 815     


Ala Asn Arg Thr Leu Leu Glu Thr Leu Leu Gly His Ser Leu Asp Thr 
            820                 825                 830         


Pro Leu Asp Ile Asp Ile Ala Gly Asp Pro Glu Tyr Glu Arg Ser Lys 
        835                 840                 845             


Gln Arg Gly Asn Ile Leu Phe Gly Val Val Ala Gly Val Val Ala Val 
    850                 855                 860                 


Ala Leu Leu Ile Ala Leu Ala Val Leu Val Arg Tyr Cys Arg Gln Arg 
865                 870                 875                 880 


Glu Ala Lys Ser Gly Tyr Gln Ala Gly Lys Lys Glu Thr Lys Asp Leu 
                885                 890                 895     


Tyr Ala Pro Lys Pro Ser Gly Lys Ala Ser Lys Gly Asn Lys Ser Lys 
            900                 905                 910         


Gly Lys Lys Ser Lys Ser Pro Lys Pro Val Lys Pro Val Glu Asp Glu 
        915                 920                 925             


Asp Glu Ala Gly Leu Gln Lys Ser Leu Lys Phe Asn Leu Met Ser Asp 
    930                 935                 940                 


Ala Pro Gly Asp Ser Pro Arg Ile His Leu Pro Leu Asn Tyr Pro Pro 
945                 950                 955                 960 


Gly Ser Pro Asp Leu Gly Arg His Tyr Arg Ser Asn Ser Pro Leu Pro 
                965                 970                 975     


Ser Ile Gln Leu Gln Pro Gln Ser Pro Ser Ala Ser Lys Lys His Gln 
            980                 985                 990         


Val Val Gln Asp Leu Pro Pro Ala  Asn Thr Phe Val Gly  Thr Gly Asp 
        995                 1000                 1005             


Thr Thr  Ser Thr Gly Ser Glu  Gln Tyr Ser Asp Tyr  Ser Tyr Arg 
    1010                 1015                 1020             


Thr Asn  Pro Pro Lys Tyr Pro  Ser Lys Gln Val Gly  Gln Pro Phe 
    1025                 1030                 1035             


Gln Leu  Ser Thr Pro Gln Pro  Leu Pro His Pro Tyr  His Gly Ala 
    1040                 1045                 1050             


Ile Trp  Thr Glu Val Trp Glu  
    1055                 1060 


<210>  2687
<211>  934
<212>  PRT
<213>  Homo sapiens

<400>  2687

Met Val Pro Glu Ala Trp Arg Ser Gly Leu Val Ser Thr Gly Arg Val 
1               5                   10                  15      


Val Gly Val Leu Leu Leu Leu Gly Ala Leu Asn Lys Ala Ser Thr Val 
            20                  25                  30          


Ile His Tyr Glu Ile Pro Glu Glu Arg Glu Lys Gly Phe Ala Val Gly 
        35                  40                  45              


Asn Val Val Ala Asn Leu Gly Leu Asp Leu Gly Ser Leu Ser Ala Arg 
    50                  55                  60                  


Arg Phe Arg Val Val Ser Gly Ala Ser Arg Arg Phe Phe Glu Val Asn 
65                  70                  75                  80  


Arg Glu Thr Gly Glu Met Phe Val Asn Asp Arg Leu Asp Arg Glu Glu 
                85                  90                  95      


Leu Cys Gly Thr Leu Pro Ser Cys Thr Val Thr Leu Glu Leu Val Val 
            100                 105                 110         


Glu Asn Pro Leu Glu Leu Phe Ser Val Glu Val Val Ile Gln Asp Ile 
        115                 120                 125             


Asn Asp Asn Asn Pro Ala Phe Pro Thr Gln Glu Met Lys Leu Glu Ile 
    130                 135                 140                 


Ser Glu Ala Val Ala Pro Gly Thr Arg Phe Pro Leu Glu Ser Ala His 
145                 150                 155                 160 


Asp Pro Asp Val Gly Ser Asn Ser Leu Gln Thr Tyr Glu Leu Ser Arg 
                165                 170                 175     


Asn Glu Tyr Phe Ala Leu Arg Val Gln Thr Arg Glu Asp Ser Thr Lys 
            180                 185                 190         


Tyr Ala Glu Leu Val Leu Glu Arg Ala Leu Asp Arg Glu Arg Glu Pro 
        195                 200                 205             


Ser Leu Gln Leu Val Leu Thr Ala Leu Asp Gly Gly Thr Pro Ala Leu 
    210                 215                 220                 


Ser Ala Ser Leu Pro Ile His Ile Lys Val Leu Asp Ala Asn Asp Asn 
225                 230                 235                 240 


Ala Pro Val Phe Asn Gln Ser Leu Tyr Arg Ala Arg Val Leu Glu Asp 
                245                 250                 255     


Ala Pro Ser Gly Thr Arg Val Val Gln Val Leu Ala Thr Asp Leu Asp 
            260                 265                 270         


Glu Gly Pro Asn Gly Glu Ile Ile Tyr Ser Phe Gly Ser His Asn Arg 
        275                 280                 285             


Ala Gly Val Arg Gln Leu Phe Ala Leu Asp Leu Val Thr Gly Met Leu 
    290                 295                 300                 


Thr Ile Lys Gly Arg Leu Asp Phe Glu Asp Thr Lys Leu His Glu Ile 
305                 310                 315                 320 


Tyr Ile Gln Ala Lys Asp Lys Gly Ala Asn Pro Glu Gly Ala His Cys 
                325                 330                 335     


Lys Val Leu Val Glu Val Val Asp Val Asn Asp Asn Ala Pro Glu Ile 
            340                 345                 350         


Thr Val Thr Ser Val Tyr Ser Pro Val Pro Glu Asp Ala Pro Leu Gly 
        355                 360                 365             


Thr Val Ile Ala Leu Leu Ser Val Thr Asp Leu Asp Ala Gly Glu Asn 
    370                 375                 380                 


Gly Leu Val Thr Cys Glu Val Pro Pro Gly Leu Pro Phe Ser Leu Thr 
385                 390                 395                 400 


Ser Ser Leu Lys Asn Tyr Phe Thr Leu Lys Thr Ser Ala Asp Leu Asp 
                405                 410                 415     


Arg Glu Thr Val Pro Glu Tyr Asn Leu Ser Ile Thr Ala Arg Asp Ala 
            420                 425                 430         


Gly Thr Pro Ser Leu Ser Ala Leu Thr Ile Val Arg Val Gln Val Ser 
        435                 440                 445             


Asp Ile Asn Asp Asn Pro Pro Gln Ser Ser Gln Ser Ser Tyr Asp Val 
    450                 455                 460                 


Tyr Ile Glu Glu Asn Asn Leu Pro Gly Ala Pro Ile Leu Asn Leu Ser 
465                 470                 475                 480 


Val Trp Asp Pro Asp Ala Pro Gln Asn Ala Arg Leu Ser Phe Phe Leu 
                485                 490                 495     


Leu Glu Gln Gly Ala Glu Thr Gly Leu Val Gly Arg Tyr Phe Thr Ile 
            500                 505                 510         


Asn Arg Asp Asn Gly Ile Val Ser Ser Leu Val Pro Leu Asp Tyr Glu 
        515                 520                 525             


Asp Arg Arg Glu Phe Glu Leu Thr Ala His Ile Ser Asp Gly Gly Thr 
    530                 535                 540                 


Pro Val Leu Ala Thr Asn Ile Ser Val Asn Ile Phe Val Thr Asp Arg 
545                 550                 555                 560 


Asn Asp Asn Ala Pro Gln Val Leu Tyr Pro Arg Pro Gly Gly Ser Ser 
                565                 570                 575     


Val Glu Met Leu Pro Arg Gly Thr Ser Ala Gly His Leu Val Ser Arg 
            580                 585                 590         


Val Val Gly Trp Asp Ala Asp Ala Gly His Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Ser Leu Leu Gly Ser Pro Asn Gln Ser Leu Phe Ala Ile Gly Leu His 
    610                 615                 620                 


Thr Gly Gln Ile Ser Thr Ala Arg Pro Val Gln Asp Thr Asp Ser Pro 
625                 630                 635                 640 


Arg Gln Thr Leu Thr Val Leu Ile Lys Asp Asn Gly Glu Pro Ser Leu 
                645                 650                 655     


Ser Thr Thr Ala Thr Leu Thr Val Ser Val Thr Glu Asp Ser Pro Glu 
            660                 665                 670         


Ala Arg Ala Glu Phe Pro Ser Gly Ser Ala Pro Arg Glu Gln Lys Lys 
        675                 680                 685             


Asn Leu Thr Phe Tyr Leu Leu Leu Ser Leu Ile Leu Val Ser Val Gly 
    690                 695                 700                 


Phe Val Val Thr Val Phe Gly Val Ile Ile Phe Lys Val Tyr Lys Trp 
705                 710                 715                 720 


Lys Gln Ser Arg Asp Leu Tyr Arg Ala Pro Val Ser Ser Leu Tyr Arg 
                725                 730                 735     


Thr Pro Gly Pro Ser Leu His Ala Asp Ala Val Arg Gly Gly Leu Met 
            740                 745                 750         


Ser Pro His Leu Tyr His Gln Val Tyr Leu Thr Thr Asp Ser Arg Arg 
        755                 760                 765             


Ser Asp Pro Leu Leu Lys Lys Pro Gly Ala Ala Ser Pro Leu Ala Ser 
    770                 775                 780                 


Arg Gln Asn Thr Leu Arg Ser Cys Asp Pro Val Phe Tyr Arg Gln Val 
785                 790                 795                 800 


Leu Gly Ala Glu Ser Ala Pro Pro Gly Gln Gln Ala Pro Pro Asn Thr 
                805                 810                 815     


Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln 
            820                 825                 830         


Asn Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu 
        835                 840                 845             


Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly 
    850                 855                 860                 


Ser Ser Thr Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg 
865                 870                 875                 880 


Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn 
                885                 890                 895     


Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys 
            900                 905                 910         


Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser 
        915                 920                 925             


Gly Lys Lys Glu Lys Lys 
    930                 


<210>  2688
<211>  938
<212>  PRT
<213>  Homo sapiens

<400>  2688

Met Leu Arg Lys Val Arg Ser Trp Thr Glu Ile Trp Arg Trp Ala Thr 
1               5                   10                  15      


Leu Leu Phe Leu Phe Tyr His Leu Gly Tyr Val Cys Gly Gln Ile Arg 
            20                  25                  30          


Tyr Pro Val Pro Glu Glu Ser Gln Glu Gly Thr Phe Val Gly Asn Val 
        35                  40                  45              


Ala Gln Asp Phe Leu Leu Asp Thr Asp Ser Leu Ser Ala Arg Arg Leu 
    50                  55                  60                  


Gln Val Ala Gly Glu Val Asn Gln Arg His Phe Arg Val Asp Leu Asp 
65                  70                  75                  80  


Ser Gly Ala Leu Leu Ile Lys Asn Pro Ile Asp Arg Glu Ala Leu Cys 
                85                  90                  95      


Gly Leu Ser Ala Ser Cys Ile Val Pro Leu Glu Phe Val Thr Glu Gly 
            100                 105                 110         


Pro Leu Glu Met Tyr Arg Ala Glu Val Glu Ile Val Asp Val Asn Asp 
        115                 120                 125             


His Ala Pro Arg Phe Pro Arg Gln Gln Leu Asp Leu Glu Ile Gly Glu 
    130                 135                 140                 


Ala Ala Pro Pro Gly Gln Arg Phe Pro Leu Glu Lys Ala Gln Asp Ala 
145                 150                 155                 160 


Asp Val Gly Ser Asn Ser Ile Ser Ser Tyr Arg Leu Ser Ser Asn Glu 
                165                 170                 175     


His Phe Ala Leu Asp Val Lys Lys Arg Ser Asp Gly Ser Leu Val Pro 
            180                 185                 190         


Glu Leu Leu Leu Glu Lys Pro Leu Asp Arg Glu Lys Gln Ser Asp Tyr 
        195                 200                 205             


Arg Leu Val Leu Thr Ala Val Asp Gly Gly Asn Pro Pro Arg Ser Gly 
    210                 215                 220                 


Thr Ala Glu Leu Arg Val Ser Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Ala Phe Gln Gln Ser Ser Tyr Arg Ile Ser Val Leu Glu Ser Ala Pro 
                245                 250                 255     


Ala Gly Met Val Leu Ile Gln Leu Asn Ala Ser Asp Pro Asp Leu Gly 
            260                 265                 270         


Pro Ser Gly Asn Val Thr Phe Tyr Phe Ser Gly His Thr Pro Asp Arg 
        275                 280                 285             


Val Arg Asn Leu Phe Ser Leu His Pro Thr Thr Gly Lys Leu Thr Leu 
    290                 295                 300                 


Leu Gly Pro Leu Asp Phe Glu Ser Glu Asn Tyr Tyr Glu Phe Asp Val 
305                 310                 315                 320 


Arg Ala Arg Asp Gly Gly Ser Pro Ala Met Glu Gln His Cys Ser Leu 
                325                 330                 335     


Arg Val Asp Leu Leu Asp Val Asn Asp Asn Ala Pro Tyr Ile Thr Val 
            340                 345                 350         


Thr Ser Glu Leu Gly Thr Leu Pro Glu Ser Ala Glu Pro Gly Thr Val 
        355                 360                 365             


Val Ala Leu Ile Ser Val Gln Asp Pro Asp Ser Gly Ser Asn Gly Asp 
    370                 375                 380                 


Val Ser Leu Arg Ile Pro Asp His Leu Pro Phe Ala Leu Lys Ser Ala 
385                 390                 395                 400 


Phe Arg Asn Gln Phe Ser Leu Val Thr Ala Gly Pro Leu Asp Arg Glu 
                405                 410                 415     


Ala Lys Ser Ser Tyr Asp Ile Met Val Thr Ala Ser Asp Ala Gly Asn 
            420                 425                 430         


Pro Pro Leu Ser Thr His Arg Thr Ile Phe Leu Asn Ile Ser Asp Val 
        435                 440                 445             


Asn Asp Asn Pro Pro Ser Phe Phe Gln Arg Ser His Glu Val Phe Val 
    450                 455                 460                 


Pro Glu Asn Asn Arg Pro Gly Asp Leu Leu Cys Ser Leu Ala Ala Ser 
465                 470                 475                 480 


Asp Pro Asp Ser Gly Leu Asn Ala Leu Ile Ser Tyr Ser Leu Leu Glu 
                485                 490                 495     


Pro Arg Asn Arg Asp Val Ser Ala Ser Ser Phe Ile Ser Leu Asn Pro 
            500                 505                 510         


Gln Thr Gly Ala Val His Ala Thr Arg Ser Phe Asp Tyr Glu Gln Thr 
        515                 520                 525             


Gln Thr Leu Gln Phe Glu Val Gln Ala Arg Asp Arg Gly Asn Pro Pro 
    530                 535                 540                 


Leu Ser Ser Thr Val Thr Val Arg Leu Phe Val Leu Asp Leu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Val Leu Arg Pro Arg Ala Arg Pro Gly Ser Leu Cys 
                565                 570                 575     


Pro Gln Ala Leu Pro Pro Ser Val Gly Ala Gly His Leu Ile Thr Lys 
            580                 585                 590         


Val Thr Ala Val Asp Leu Asp Ser Gly Tyr Asn Ala Trp Val Ser Tyr 
        595                 600                 605             


Gln Leu Leu Glu Ala Pro Asp Pro Ser Leu Phe Ala Val Ser Arg Tyr 
    610                 615                 620                 


Ala Gly Glu Val Arg Thr Ala Val Pro Ile Pro Ala Asp Leu Pro Pro 
625                 630                 635                 640 


Gln Lys Leu Val Ile Val Val Lys Asp Ser Gly Ser Pro Pro Leu Ser 
                645                 650                 655     


Thr Ser Val Thr Leu Leu Val Ser Leu Glu Glu Asp Thr His Pro Val 
            660                 665                 670         


Val Pro Asp Leu Arg Glu Ser Ser Ala Pro Arg Glu Gly Glu Ser Arg 
        675                 680                 685             


Leu Thr Leu Tyr Leu Ala Val Ser Leu Val Ala Ile Cys Phe Val Ser 
    690                 695                 700                 


Phe Gly Ser Phe Val Ala Leu Leu Ser Lys Cys Leu Arg Gly Ala Ala 
705                 710                 715                 720 


Cys Gly Val Thr Cys Phe Pro Ala Gly Thr Cys Ala Cys Leu Thr Arg 
                725                 730                 735     


Ser Arg Arg Arg Glu Gly Leu Pro Pro Ser Asn Gly Ile Leu Arg Ile 
            740                 745                 750         


Gln Leu Gly Ser Asp Asp Pro Ile Lys Phe Val Asp Val Gly Gly His 
        755                 760                 765             


Ser His Gly Cys Thr Pro Leu Ala Ser Ala Pro Thr Arg Ser Asp Ser 
    770                 775                 780                 


Phe Met Met Val Lys Ser Pro Ser Ala Pro Met Ala Gly Glu Pro Val 
785                 790                 795                 800 


Arg Pro Ser Cys Pro Pro Ser Asp Leu Leu Tyr Gly Leu Glu Gln Ala 
                805                 810                 815     


Pro Pro Asn Thr Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr 
            820                 825                 830         


Ser Gly Ser Gln Asn Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln 
        835                 840                 845             


Phe Asp Thr Glu Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser Glu 
    850                 855                 860                 


Ala Ala Asp Gly Ser Ser Thr Leu Gly Gly Gly Ala Gly Thr Met Gly 
865                 870                 875                 880 


Leu Ser Ala Arg Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro Asp 
                885                 890                 895     


Tyr Arg Gln Asn Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn 
            900                 905                 910         


Ala Ala Gly Lys Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn 
        915                 920                 925             


Lys Lys Lys Ser Gly Lys Lys Glu Lys Lys 
    930                 935             


<210>  2689
<211>  944
<212>  PRT
<213>  Homo sapiens

<400>  2689

Met Gly Pro Lys Thr Leu Pro Gln Leu Ala Gly Lys Trp Gln Val Leu 
1               5                   10                  15      


Cys Met Leu Ser Leu Cys Cys Trp Gly Trp Val Ser Gly Gln Leu Arg 
            20                  25                  30          


Tyr Ser Val Val Glu Glu Ser Glu Pro Gly Thr Leu Val Gly Asn Val 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Lys Met Thr Asp Leu Leu Ser Arg Arg Leu 
    50                  55                  60                  


Gln Leu Gly Ser Glu Glu Asn Gly Arg Tyr Phe Ser Leu Ser Leu Met 
65                  70                  75                  80  


Ser Gly Ala Leu Ala Val Asn Gln Lys Ile Asp Arg Glu Ser Leu Cys 
                85                  90                  95      


Gly Ala Ser Thr Ser Cys Leu Leu Pro Val Gln Val Val Thr Glu His 
            100                 105                 110         


Pro Leu Glu Leu Ile Arg Val Glu Val Glu Ile Leu Asp Leu Asn Asp 
        115                 120                 125             


Asn Ser Pro Ser Phe Ala Thr Pro Glu Arg Glu Met Arg Ile Ser Glu 
    130                 135                 140                 


Ser Ala Ala Ser Gly Ala Arg Phe Pro Leu Asp Ser Ala Gln Asp Pro 
145                 150                 155                 160 


Asp Val Gly Thr Asn Thr Val Ser Phe Tyr Thr Leu Ser Pro Asn Ser 
                165                 170                 175     


His Phe Ser Leu Asn Val Lys Thr Leu Lys Asp Gly Lys Pro Phe Pro 
            180                 185                 190         


Glu Leu Val Leu Glu Gln Gln Leu Asp Arg Glu Ala Gln Ala Arg His 
        195                 200                 205             


Gln Leu Val Leu Thr Ala Val Asp Gly Gly Thr Pro Ala Arg Ser Gly 
    210                 215                 220                 


Thr Thr Leu Ile Ser Val Ile Val Leu Asp Ile Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Thr Phe Gln Ser Ser Val Leu Arg Val Gly Ile Pro Glu Asn Ala Pro 
                245                 250                 255     


Ile Gly Thr Leu Leu Leu Arg Leu Asn Ala Thr Asp Pro Asp Glu Gly 
            260                 265                 270         


Thr Asn Gly Gln Leu Asp Tyr Ser Phe Gly Asp His Thr Ser Glu Ala 
        275                 280                 285             


Val Arg Asn Leu Phe Gly Leu Asp Pro Ser Ser Gly Ala Ile His Val 
    290                 295                 300                 


Leu Gly Pro Ile Asp Phe Glu Glu Ser Arg Phe Tyr Glu Ile His Ala 
305                 310                 315                 320 


Arg Ala Arg Asp Gln Gly Gln Pro Ala Met Glu Gly His Cys Val Ile 
                325                 330                 335     


Gln Val Asp Val Gly Asp Val Asn Asp Asn Ala Pro Glu Val Leu Leu 
            340                 345                 350         


Ala Ser Leu Ala Asn Pro Val Leu Glu Ser Thr Pro Val Gly Thr Val 
        355                 360                 365             


Val Gly Leu Phe Asn Val Arg Asp Arg Asp Ser Gly Arg Asn Gly Glu 
    370                 375                 380                 


Val Ser Leu Asp Ile Ser Pro Asp Leu Pro Phe Gln Ile Lys Pro Ser 
385                 390                 395                 400 


Glu Asn His Tyr Ser Leu Leu Thr Ser Gln Pro Leu Asp Arg Glu Ala 
                405                 410                 415     


Thr Ser His Tyr Ile Ile Glu Leu Leu Ala Ser Asp Ala Gly Ser Pro 
            420                 425                 430         


Ser Leu His Lys His Leu Thr Ile Arg Leu Asn Ile Ser Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Arg Phe Asn Gln Gln Leu Tyr Thr Ala Tyr Ile Leu 
    450                 455                 460                 


Glu Asn Arg Pro Pro Gly Ser Leu Leu Cys Thr Val Ala Ala Ser Asp 
465                 470                 475                 480 


Pro Asp Thr Gly Asp Asn Ala Arg Leu Thr Tyr Ser Ile Val Gly Asn 
                485                 490                 495     


Gln Val Gln Gly Ala Pro Ala Ser Ser Phe Val Tyr Val Asn Pro Glu 
            500                 505                 510         


Asp Gly Arg Ile Phe Ala Gln Arg Thr Phe Asp Tyr Glu Leu Leu Gln 
        515                 520                 525             


Met Leu Gln Ile Val Val Gly Val Arg Asp Ser Gly Ser Pro Pro Leu 
    530                 535                 540                 


His Ala Asn Thr Ser Leu His Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Val Leu His Pro Arg Pro Asp Trp Glu His Ser Ala Pro 
                565                 570                 575     


Gln Arg Leu Pro Arg Ser Ala Pro Pro Gly Ser Leu Val Thr Lys Val 
            580                 585                 590         


Thr Ala Val Asp Ala Asp Ala Gly His Asn Ala Trp Leu Ser Tyr Ser 
        595                 600                 605             


Leu Leu Pro Gln Ser Thr Ala Pro Gly Leu Phe Leu Val Ser Thr His 
    610                 615                 620                 


Thr Gly Glu Val Arg Thr Ala Arg Ala Leu Leu Glu Asp Asp Ser Asp 
625                 630                 635                 640 


Thr Gln Gln Val Val Val Leu Val Arg Asp Asn Gly Asp Pro Ser Leu 
                645                 650                 655     


Ser Ser Thr Ala Thr Val Leu Leu Val Leu Glu Asp Glu Asp Pro Glu 
            660                 665                 670         


Glu Met Pro Lys Ser Ser Asp Phe Leu Ile His Pro Pro Glu Arg Ser 
        675                 680                 685             


Asp Leu Thr Leu Tyr Leu Ile Val Ala Leu Ala Thr Val Ser Leu Leu 
    690                 695                 700                 


Ser Leu Val Thr Phe Thr Phe Leu Ser Ala Lys Cys Leu Gln Gly Asn 
705                 710                 715                 720 


Ala Asp Gly Asp Gly Gly Gly Gly Gln Cys Cys Arg Arg Gln Asp Ser 
                725                 730                 735     


Pro Ser Pro Asp Phe Tyr Lys Gln Ser Ser Pro Asn Leu Gln Val Ser 
            740                 745                 750         


Ser Asp Gly Thr Leu Lys Tyr Met Glu Val Thr Leu Arg Pro Thr Asp 
        755                 760                 765             


Ser Gln Ser His Cys Tyr Arg Thr Cys Phe Ser Pro Ala Ser Asp Gly 
    770                 775                 780                 


Ser Asp Phe Thr Phe Leu Arg Pro Leu Ser Val Gln Gln Pro Thr Ala 
785                 790                 795                 800 


Leu Ala Leu Glu Pro Asp Ala Ile Arg Ser Arg Ser Asn Thr Leu Arg 
                805                 810                 815     


Glu Arg Ser Gln Gln Ala Pro Pro Asn Thr Asp Trp Arg Phe Ser Gln 
            820                 825                 830         


Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly Asp Asp Thr Gly 
        835                 840                 845             


Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu Gln Ala Met Ile 
    850                 855                 860                 


Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser Thr Leu Gly Gly 
865                 870                 875                 880 


Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly Pro Gln Phe Thr 
                885                 890                 895     


Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr Ile Pro Gly Ser 
            900                 905                 910         


Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp Gly Lys Ala Pro 
        915                 920                 925             


Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys Lys Glu Lys Lys 
    930                 935                 940                 


<210>  2690
<211>  1070
<212>  PRT
<213>  Homo sapiens

<400>  2690

Met Ser Pro Val Arg Arg Trp Gly Ser Pro Cys Leu Phe Pro Leu Gln 
1               5                   10                  15      


Leu Phe Ser Leu Cys Trp Val Leu Ser Val Ala Gln Ser Lys Thr Val 
            20                  25                  30          


Arg Tyr Ser Thr Phe Glu Glu Asp Ala Pro Gly Thr Val Ile Gly Thr 
        35                  40                  45              


Leu Ala Glu Asp Leu His Met Lys Val Ser Gly Asp Thr Ser Phe Arg 
    50                  55                  60                  


Leu Met Lys Gln Phe Asn Ser Ser Leu Leu Arg Val Arg Glu Gly Asp 
65                  70                  75                  80  


Gly Gln Leu Thr Val Gly Asp Ala Gly Leu Asp Arg Glu Arg Leu Cys 
                85                  90                  95      


Gly Gln Ala Pro Gln Cys Val Leu Ala Phe Asp Val Val Ser Phe Ser 
            100                 105                 110         


Gln Glu Gln Phe Arg Leu Val His Val Glu Val Glu Val Arg Asp Val 
        115                 120                 125             


Asn Asp His Ala Pro Arg Phe Pro Arg Ala Gln Ile Pro Val Glu Val 
    130                 135                 140                 


Ser Glu Gly Ala Ala Val Gly Thr Arg Ile Pro Leu Glu Val Pro Val 
145                 150                 155                 160 


Asp Glu Asp Val Gly Ala Asn Gly Leu Gln Thr Val Arg Leu Ala Glu 
                165                 170                 175     


Pro His Ser Pro Phe Arg Val Glu Leu Gln Thr Arg Ala Asp Gly Ala 
            180                 185                 190         


Gln Cys Ala Asp Leu Val Leu Leu Gln Glu Leu Asp Arg Glu Ser Gln 
        195                 200                 205             


Ala Ala Tyr Ser Leu Glu Leu Val Ala Gln Asp Gly Gly Arg Pro Pro 
    210                 215                 220                 


Arg Ser Ala Thr Ala Ala Leu Ser Val Arg Val Leu Asp Ala Asn Asp 
225                 230                 235                 240 


His Ser Pro Ala Phe Pro Gln Gly Ala Val Ala Glu Val Glu Leu Ala 
                245                 250                 255     


Glu Asp Ala Pro Val Gly Ser Leu Leu Leu Asp Leu Asp Ala Ala Asp 
            260                 265                 270         


Pro Asp Glu Gly Pro Asn Gly Asp Val Val Phe Ala Phe Gly Ala Arg 
        275                 280                 285             


Thr Pro Pro Glu Ala Arg Arg Leu Phe Arg Leu Asp Pro Arg Ser Gly 
    290                 295                 300                 


Arg Leu Thr Leu Ala Gly Pro Val Asp Tyr Glu Arg Gln Asp Thr Tyr 
305                 310                 315                 320 


Glu Leu Asp Val Arg Ala Gln Asp Arg Gly Pro Gly Pro Arg Ala Ala 
                325                 330                 335     


Thr Cys Lys Val Ile Val Arg Ile Arg Asp Val Asn Asp Asn Ala Pro 
            340                 345                 350         


Asp Ile Ala Ile Thr Pro Leu Ala Ala Pro Gly Ala Pro Ala Thr Ser 
        355                 360                 365             


Pro Phe Ala Ala Ala Ala Ala Ala Ala Ala Leu Gly Gly Ala Asp Ala 
    370                 375                 380                 


Ser Ser Pro Ala Gly Ala Gly Thr Pro Glu Ala Gly Ala Thr Ser Leu 
385                 390                 395                 400 


Val Pro Glu Gly Ala Ala Arg Glu Ser Leu Val Ala Leu Val Ser Thr 
                405                 410                 415     


Ser Asp Arg Asp Ser Gly Ala Asn Gly Gln Val Arg Cys Ala Leu Tyr 
            420                 425                 430         


Gly His Glu His Phe Arg Leu Gln Pro Ala Tyr Ala Gly Ser Tyr Leu 
        435                 440                 445             


Val Val Thr Ala Ala Ser Leu Asp Arg Glu Arg Ile Ala Glu Tyr Asn 
    450                 455                 460                 


Leu Thr Leu Val Ala Glu Asp Arg Gly Ala Pro Pro Leu Arg Thr Val 
465                 470                 475                 480 


Arg Pro Tyr Thr Val Arg Val Gly Asp Glu Asn Asp Asn Ala Pro Leu 
                485                 490                 495     


Phe Thr Arg Pro Val Tyr Glu Val Ser Val Arg Glu Asn Asn Pro Pro 
            500                 505                 510         


Gly Ala Tyr Leu Ala Thr Val Ala Ala Arg Asp Arg Asp Leu Gly Arg 
        515                 520                 525             


Asn Gly Gln Val Thr Tyr Arg Leu Leu Glu Ala Glu Val Gly Arg Ala 
    530                 535                 540                 


Gly Gly Ala Val Ser Thr Tyr Val Ser Val Asp Pro Ala Thr Gly Ala 
545                 550                 555                 560 


Ile Tyr Ala Leu Arg Ser Phe Asp Tyr Glu Thr Leu Arg Gln Leu Asp 
                565                 570                 575     


Val Arg Ile Gln Ala Ser Asp Gly Gly Ser Pro Gln Leu Ser Ser Ser 
            580                 585                 590         


Ala Leu Val Gln Val Arg Val Leu Asp Gln Asn Asp His Ala Pro Val 
        595                 600                 605             


Leu Val His Pro Ala Pro Ala Asn Gly Ser Leu Glu Val Ala Val Pro 
    610                 615                 620                 


Gly Arg Thr Ala Lys Asp Thr Val Val Ala Arg Val Gln Ala Arg Asp 
625                 630                 635                 640 


Ala Asp Glu Gly Ala Asn Gly Glu Leu Ala Phe Glu Leu Gln Gln Gln 
                645                 650                 655     


Glu Pro Arg Glu Ala Phe Ala Ile Gly Arg Arg Thr Gly Glu Ile Leu 
            660                 665                 670         


Leu Thr Gly Asp Leu Ser Gln Glu Pro Pro Gly Arg Val Phe Arg Ala 
        675                 680                 685             


Leu Leu Val Ile Ser Asp Gly Gly Arg Pro Pro Leu Thr Thr Thr Ala 
    690                 695                 700                 


Thr Val Ser Phe Val Val Thr Ala Gly Gly Gly Arg Gly Pro Ala Ala 
705                 710                 715                 720 


Pro Ala Ser Ala Gly Ser Pro Glu Arg Ser Arg Pro Pro Gly Ser Arg 
                725                 730                 735     


Leu Gly Val Ser Gly Ser Val Leu Gln Trp Asp Thr Pro Leu Ile Val 
            740                 745                 750         


Ile Ile Val Leu Ala Gly Ser Cys Thr Leu Leu Leu Ala Ala Ile Ile 
        755                 760                 765             


Ala Ile Ala Thr Thr Cys Asn Arg Arg Lys Lys Glu Val Arg Lys Gly 
    770                 775                 780                 


Gly Ala Leu Arg Glu Glu Arg Pro Gly Ala Ala Gly Gly Gly Ala Ser 
785                 790                 795                 800 


Ala Pro Gly Ser Pro Glu Glu Ala Ala Arg Gly Ala Gly Pro Arg Pro 
                805                 810                 815     


Asn Met Phe Asp Val Leu Thr Phe Pro Gly Thr Gly Lys Ala Pro Phe 
            820                 825                 830         


Gly Ser Pro Ala Ala Asp Ala Pro Pro Pro Ala Val Ala Ala Ala Glu 
        835                 840                 845             


Val Pro Gly Ser Glu Gly Gly Ser Ala Thr Gly Glu Ser Ala Cys His 
    850                 855                 860                 


Phe Glu Gly Gln Gln Arg Leu Arg Gly Ala His Ala Glu Pro Tyr Gly 
865                 870                 875                 880 


Ala Ser Pro Gly Phe Gly Lys Glu Pro Ala Pro Pro Val Ala Val Trp 
                885                 890                 895     


Lys Gly His Ser Phe Asn Thr Ile Ser Gly Arg Glu Ala Glu Lys Phe 
            900                 905                 910         


Ser Gly Lys Asp Ser Gly Lys Gly Asp Ser Asp Phe Asn Asp Ser Asp 
        915                 920                 925             


Ser Asp Ile Ser Gly Asp Ala Leu Lys Lys Asp Leu Ile Asn His Met 
    930                 935                 940                 


Gln Ser Gly Leu Trp Ala Cys Thr Ala Glu Cys Lys Ile Leu Gly His 
945                 950                 955                 960 


Ser Asp Arg Cys Trp Ser Pro Ser Cys Ser Gly Pro Asn Ala His Pro 
                965                 970                 975     


Ser Pro His Pro Pro Ala Gln Met Ser Thr Phe Cys Lys Ser Thr Ser 
            980                 985                 990         


Leu Pro Arg Asp Pro Leu Arg Arg  Asp Asn Tyr Tyr Gln  Ala Gln Leu 
        995                 1000                 1005             


Pro Lys  Thr Val Gly Leu Gln  Ser Val Tyr Glu Lys  Val Leu His 
    1010                 1015                 1020             


Arg Asp  Tyr Asp Arg Thr Val  Thr Leu Leu Ser Pro  Pro Arg Pro 
    1025                 1030                 1035             


Gly Arg  Leu Pro Asp Leu Gln  Glu Ile Gly Val Pro  Leu Tyr Gln 
    1040                 1045                 1050             


Ser Pro  Pro Gly Arg Tyr Leu  Ser Pro Lys Lys Gly  Ala Asn Glu 
    1055                 1060                 1065             


Asn Val  
    1070 


<210>  2691
<211>  1106
<212>  PRT
<213>  Homo sapiens

<400>  2691

Met Arg Leu Pro Gly Ala Met Pro Ala Leu Ala Leu Lys Gly Glu Leu 
1               5                   10                  15      


Leu Leu Leu Ser Leu Leu Leu Leu Leu Glu Pro Gln Ile Ser Gln Gly 
            20                  25                  30          


Leu Val Val Thr Pro Pro Gly Pro Glu Leu Val Leu Asn Val Ser Ser 
        35                  40                  45              


Thr Phe Val Leu Thr Cys Ser Gly Ser Ala Pro Val Val Trp Glu Arg 
    50                  55                  60                  


Met Ser Gln Glu Pro Pro Gln Glu Met Ala Lys Ala Gln Asp Gly Thr 
65                  70                  75                  80  


Phe Ser Ser Val Leu Thr Leu Thr Asn Leu Thr Gly Leu Asp Thr Gly 
                85                  90                  95      


Glu Tyr Phe Cys Thr His Asn Asp Ser Arg Gly Leu Glu Thr Asp Glu 
            100                 105                 110         


Arg Lys Arg Leu Tyr Ile Phe Val Pro Asp Pro Thr Val Gly Phe Leu 
        115                 120                 125             


Pro Asn Asp Ala Glu Glu Leu Phe Ile Phe Leu Thr Glu Ile Thr Glu 
    130                 135                 140                 


Ile Thr Ile Pro Cys Arg Val Thr Asp Pro Gln Leu Val Val Thr Leu 
145                 150                 155                 160 


His Glu Lys Lys Gly Asp Val Ala Leu Pro Val Pro Tyr Asp His Gln 
                165                 170                 175     


Arg Gly Phe Ser Gly Ile Phe Glu Asp Arg Ser Tyr Ile Cys Lys Thr 
            180                 185                 190         


Thr Ile Gly Asp Arg Glu Val Asp Ser Asp Ala Tyr Tyr Val Tyr Arg 
        195                 200                 205             


Leu Gln Val Ser Ser Ile Asn Val Ser Val Asn Ala Val Gln Thr Val 
    210                 215                 220                 


Val Arg Gln Gly Glu Asn Ile Thr Leu Met Cys Ile Val Ile Gly Asn 
225                 230                 235                 240 


Glu Val Val Asn Phe Glu Trp Thr Tyr Pro Arg Lys Glu Ser Gly Arg 
                245                 250                 255     


Leu Val Glu Pro Val Thr Asp Phe Leu Leu Asp Met Pro Tyr His Ile 
            260                 265                 270         


Arg Ser Ile Leu His Ile Pro Ser Ala Glu Leu Glu Asp Ser Gly Thr 
        275                 280                 285             


Tyr Thr Cys Asn Val Thr Glu Ser Val Asn Asp His Gln Asp Glu Lys 
    290                 295                 300                 


Ala Ile Asn Ile Thr Val Val Glu Ser Gly Tyr Val Arg Leu Leu Gly 
305                 310                 315                 320 


Glu Val Gly Thr Leu Gln Phe Ala Glu Leu His Arg Ser Arg Thr Leu 
                325                 330                 335     


Gln Val Val Phe Glu Ala Tyr Pro Pro Pro Thr Val Leu Trp Phe Lys 
            340                 345                 350         


Asp Asn Arg Thr Leu Gly Asp Ser Ser Ala Gly Glu Ile Ala Leu Ser 
        355                 360                 365             


Thr Arg Asn Val Ser Glu Thr Arg Tyr Val Ser Glu Leu Thr Leu Val 
    370                 375                 380                 


Arg Val Lys Val Ala Glu Ala Gly His Tyr Thr Met Arg Ala Phe His 
385                 390                 395                 400 


Glu Asp Ala Glu Val Gln Leu Ser Phe Gln Leu Gln Ile Asn Val Pro 
                405                 410                 415     


Val Arg Val Leu Glu Leu Ser Glu Ser His Pro Asp Ser Gly Glu Gln 
            420                 425                 430         


Thr Val Arg Cys Arg Gly Arg Gly Met Pro Gln Pro Asn Ile Ile Trp 
        435                 440                 445             


Ser Ala Cys Arg Asp Leu Lys Arg Cys Pro Arg Glu Leu Pro Pro Thr 
    450                 455                 460                 


Leu Leu Gly Asn Ser Ser Glu Glu Glu Ser Gln Leu Glu Thr Asn Val 
465                 470                 475                 480 


Thr Tyr Trp Glu Glu Glu Gln Glu Phe Glu Val Val Ser Thr Leu Arg 
                485                 490                 495     


Leu Gln His Val Asp Arg Pro Leu Ser Val Arg Cys Thr Leu Arg Asn 
            500                 505                 510         


Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu 
        515                 520                 525             


Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu 
    530                 535                 540                 


Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro 
545                 550                 555                 560 


Arg Tyr Glu Ile Arg Trp Lys Val Ile Glu Ser Val Ser Ser Asp Gly 
                565                 570                 575     


His Glu Tyr Ile Tyr Val Asp Pro Met Gln Leu Pro Tyr Asp Ser Thr 
            580                 585                 590         


Trp Glu Leu Pro Arg Asp Gln Leu Val Leu Gly Arg Thr Leu Gly Ser 
        595                 600                 605             


Gly Ala Phe Gly Gln Val Val Glu Ala Thr Ala His Gly Leu Ser His 
    610                 615                 620                 


Ser Gln Ala Thr Met Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala 
625                 630                 635                 640 


Arg Ser Ser Glu Lys Gln Ala Leu Met Ser Glu Leu Lys Ile Met Ser 
                645                 650                 655     


His Leu Gly Pro His Leu Asn Val Val Asn Leu Leu Gly Ala Cys Thr 
            660                 665                 670         


Lys Gly Gly Pro Ile Tyr Ile Ile Thr Glu Tyr Cys Arg Tyr Gly Asp 
        675                 680                 685             


Leu Val Asp Tyr Leu His Arg Asn Lys His Thr Phe Leu Gln His His 
    690                 695                 700                 


Ser Asp Lys Arg Arg Pro Pro Ser Ala Glu Leu Tyr Ser Asn Ala Leu 
705                 710                 715                 720 


Pro Val Gly Leu Pro Leu Pro Ser His Val Ser Leu Thr Gly Glu Ser 
                725                 730                 735     


Asp Gly Gly Tyr Met Asp Met Ser Lys Asp Glu Ser Val Asp Tyr Val 
            740                 745                 750         


Pro Met Leu Asp Met Lys Gly Asp Val Lys Tyr Ala Asp Ile Glu Ser 
        755                 760                 765             


Ser Asn Tyr Met Ala Pro Tyr Asp Asn Tyr Val Pro Ser Ala Pro Glu 
    770                 775                 780                 


Arg Thr Cys Arg Ala Thr Leu Ile Asn Glu Ser Pro Val Leu Ser Tyr 
785                 790                 795                 800 


Met Asp Leu Val Gly Phe Ser Tyr Gln Val Ala Asn Gly Met Glu Phe 
                805                 810                 815     


Leu Ala Ser Lys Asn Cys Val His Arg Asp Leu Ala Ala Arg Asn Val 
            820                 825                 830         


Leu Ile Cys Glu Gly Lys Leu Val Lys Ile Cys Asp Phe Gly Leu Ala 
        835                 840                 845             


Arg Asp Ile Met Arg Asp Ser Asn Tyr Ile Ser Lys Gly Ser Thr Phe 
    850                 855                 860                 


Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Ser Leu Tyr 
865                 870                 875                 880 


Thr Thr Leu Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile 
                885                 890                 895     


Phe Thr Leu Gly Gly Thr Pro Tyr Pro Glu Leu Pro Met Asn Glu Gln 
            900                 905                 910         


Phe Tyr Asn Ala Ile Lys Arg Gly Tyr Arg Met Ala Gln Pro Ala His 
        915                 920                 925             


Ala Ser Asp Glu Ile Tyr Glu Ile Met Gln Lys Cys Trp Glu Glu Lys 
    930                 935                 940                 


Phe Glu Ile Arg Pro Pro Phe Ser Gln Leu Val Leu Leu Leu Glu Arg 
945                 950                 955                 960 


Leu Leu Gly Glu Gly Tyr Lys Lys Lys Tyr Gln Gln Val Asp Glu Glu 
                965                 970                 975     


Phe Leu Arg Ser Asp His Pro Ala Ile Leu Arg Ser Gln Ala Arg Leu 
            980                 985                 990         


Pro Gly Phe His Gly Leu Arg Ser  Pro Leu Asp Thr Ser  Ser Val Leu 
        995                 1000                 1005             


Tyr Thr  Ala Val Gln Pro Asn  Glu Gly Asp Asn Asp  Tyr Ile Ile 
    1010                 1015                 1020             


Pro Leu  Pro Asp Pro Lys Pro  Glu Val Ala Asp Glu  Gly Pro Leu 
    1025                 1030                 1035             


Glu Gly  Ser Pro Ser Leu Ala  Ser Ser Thr Leu Asn  Glu Val Asn 
    1040                 1045                 1050             


Thr Ser  Ser Thr Ile Ser Cys  Asp Ser Pro Leu Glu  Pro Gln Asp 
    1055                 1060                 1065             


Glu Pro  Glu Pro Glu Pro Gln  Leu Glu Leu Gln Val  Glu Pro Glu 
    1070                 1075                 1080             


Pro Glu  Leu Glu Gln Leu Pro  Asp Ser Gly Cys Pro  Ala Pro Arg 
    1085                 1090                 1095             


Ala Glu  Ala Glu Asp Ser Phe  Leu 
    1100                 1105     


<210>  2692
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  2692

Met Ala Pro Ala Ala Ala Ser Pro Pro Glu Val Ile Arg Ala Ala Gln 
1               5                   10                  15      


Lys Asp Glu Tyr Tyr Arg Gly Gly Leu Arg Ser Ala Ala Gly Gly Ala 
            20                  25                  30          


Leu His Ser Leu Ala Gly Ala Arg Lys Trp Leu Glu Trp Arg Lys Glu 
        35                  40                  45              


Val Glu Leu Leu Ser Asp Val Ala Tyr Phe Gly Leu Thr Thr Leu Ala 
    50                  55                  60                  


Gly Tyr Gln Thr Leu Gly Glu Glu Tyr Val Ser Ile Ile Gln Val Asp 
65                  70                  75                  80  


Pro Ser Arg Ile His Val Pro Ser Ser Leu Arg Arg Gly Val Leu Val 
                85                  90                  95      


Thr Leu His Ala Val Leu Pro Tyr Leu Leu Asp Lys Ala Leu Leu Pro 
            100                 105                 110         


Leu Glu Gln Glu Leu Gln Ala Asp Pro Asp Ser Gly Arg Pro Leu Gln 
        115                 120                 125             


Gly Ser Leu Gly Pro Gly Gly Arg Gly Cys Ser Gly Ala Arg Arg Trp 
    130                 135                 140                 


Met Arg His His Thr Ala Thr Leu Thr Glu Gln Gln Arg Arg Ala Leu 
145                 150                 155                 160 


Leu Arg Ala Val Phe Val Leu Arg Gln Gly Leu Ala Cys Leu Gln Arg 
                165                 170                 175     


Leu His Val Ala Trp Phe Tyr Ile His Gly Val Phe Tyr His Leu Ala 
            180                 185                 190         


Lys Arg Leu Thr Gly Ile Thr Tyr Leu Arg Val Arg Ser Leu Pro Gly 
        195                 200                 205             


Glu Asp Leu Arg Ala Arg Val Ser Tyr Arg Leu Leu Gly Val Ile Ser 
    210                 215                 220                 


Leu Leu His Leu Val Leu Ser Met Gly Leu Gln Leu Tyr Gly Phe Arg 
225                 230                 235                 240 


Gln Arg Gln Arg Ala Arg Lys Glu Trp Arg Leu His Arg Gly Leu Ser 
                245                 250                 255     


His Arg Arg Ala Ser Leu Glu Glu Arg Ala Val Ser Arg Asn Pro Leu 
            260                 265                 270         


Cys Thr Leu Cys Leu Glu Glu Arg Arg His Pro Thr Ala Thr Pro Cys 
        275                 280                 285             


Gly His Leu Phe Cys Trp Glu Cys Ile Thr Ala Trp Cys Ser Ser Lys 
    290                 295                 300                 


Ala Glu Cys Pro Leu Cys Arg Glu Lys Phe Pro Pro Gln Lys Leu Ile 
305                 310                 315                 320 


Tyr Leu Arg His Tyr Arg 
                325     


<210>  2693
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  2693

Met Ser Ser Ala Ala Gly Phe Cys Ala Ser Arg Pro Gly Leu Leu Phe 
1               5                   10                  15      


Leu Gly Leu Leu Leu Leu Pro Leu Val Val Ala Phe Ala Ser Ala Glu 
            20                  25                  30          


Ala Glu Glu Asp Gly Asp Leu Gln Cys Leu Cys Val Lys Thr Thr Ser 
        35                  40                  45              


Gln Val Arg Pro Arg His Ile Thr Ser Leu Glu Val Ile Lys Ala Gly 
    50                  55                  60                  


Pro His Cys Pro Thr Ala Gln Leu Ile Ala Thr Leu Lys Asn Gly Arg 
65                  70                  75                  80  


Lys Ile Cys Leu Asp Leu Gln Ala Pro Leu Tyr Lys Lys Ile Ile Lys 
                85                  90                  95      


Lys Leu Leu Glu Ser 
            100     


<210>  2694
<211>  784
<212>  PRT
<213>  Homo sapiens

<400>  2694

Met Asp Ala Asp Asp Ser Arg Ala Pro Lys Gly Ser Leu Arg Lys Phe 
1               5                   10                  15      


Leu Glu His Leu Ser Gly Ala Gly Lys Ala Ile Gly Val Leu Thr Ser 
            20                  25                  30          


Gly Gly Asp Ala Gln Gly Met Asn Ala Ala Val Arg Ala Val Val Arg 
        35                  40                  45              


Met Gly Ile Tyr Val Gly Ala Lys Val Tyr Phe Ile Tyr Glu Gly Tyr 
    50                  55                  60                  


Gln Gly Met Val Asp Gly Gly Ser Asn Ile Ala Glu Ala Asp Trp Glu 
65                  70                  75                  80  


Ser Val Ser Ser Ile Leu Gln Val Gly Gly Thr Ile Ile Gly Ser Ala 
                85                  90                  95      


Arg Cys Gln Ala Phe Arg Thr Arg Glu Gly Arg Leu Lys Ala Ala Cys 
            100                 105                 110         


Asn Leu Leu Gln Arg Gly Ile Thr Asn Leu Cys Val Ile Gly Gly Asp 
        115                 120                 125             


Gly Ser Leu Thr Gly Ala Asn Leu Phe Arg Lys Glu Trp Ser Gly Leu 
    130                 135                 140                 


Leu Glu Glu Leu Ala Arg Asn Gly Gln Ile Asp Lys Glu Ala Val Gln 
145                 150                 155                 160 


Lys Tyr Ala Tyr Leu Asn Val Val Gly Met Val Gly Ser Ile Asp Asn 
                165                 170                 175     


Asp Phe Cys Gly Thr Asp Met Thr Ile Gly Thr Asp Ser Ala Leu His 
            180                 185                 190         


Arg Ile Ile Glu Val Val Asp Ala Ile Met Thr Thr Ala Gln Ser His 
        195                 200                 205             


Gln Arg Thr Phe Val Leu Glu Val Met Gly Arg His Cys Gly Tyr Leu 
    210                 215                 220                 


Ala Leu Val Ser Ala Leu Ala Cys Gly Ala Asp Trp Val Phe Leu Pro 
225                 230                 235                 240 


Glu Ser Pro Pro Glu Glu Gly Trp Glu Glu Gln Met Cys Val Lys Leu 
                245                 250                 255     


Ser Glu Asn Arg Ala Arg Lys Lys Arg Leu Asn Ile Ile Ile Val Ala 
            260                 265                 270         


Glu Gly Ala Ile Asp Thr Gln Asn Lys Pro Ile Thr Ser Glu Lys Ile 
        275                 280                 285             


Lys Glu Leu Val Val Thr Gln Leu Gly Tyr Asp Thr Arg Val Thr Ile 
    290                 295                 300                 


Leu Gly His Val Gln Arg Gly Gly Thr Pro Ser Ala Phe Asp Arg Ile 
305                 310                 315                 320 


Leu Ala Ser Arg Met Gly Val Glu Ala Val Ile Ala Leu Leu Glu Ala 
                325                 330                 335     


Thr Pro Asp Thr Pro Ala Cys Val Val Ser Leu Asn Gly Asn His Ala 
            340                 345                 350         


Val Arg Leu Pro Leu Met Glu Cys Val Gln Met Thr Gln Asp Val Gln 
        355                 360                 365             


Lys Ala Met Asp Glu Arg Arg Phe Gln Asp Ala Val Arg Leu Arg Gly 
    370                 375                 380                 


Arg Ser Phe Ala Gly Asn Leu Asn Thr Tyr Lys Arg Leu Ala Ile Lys 
385                 390                 395                 400 


Leu Pro Asp Asp Gln Ile Pro Lys Thr Asn Cys Asn Val Ala Val Ile 
                405                 410                 415     


Asn Val Gly Ala Pro Ala Ala Gly Met Asn Ala Ala Val Arg Ser Ala 
            420                 425                 430         


Val Arg Val Gly Ile Ala Asp Gly His Arg Met Leu Ala Ile Tyr Asp 
        435                 440                 445             


Gly Phe Asp Gly Phe Ala Lys Gly Gln Ile Lys Glu Ile Gly Trp Thr 
    450                 455                 460                 


Asp Val Gly Gly Trp Thr Gly Gln Gly Gly Ser Ile Leu Gly Thr Lys 
465                 470                 475                 480 


Arg Val Leu Pro Gly Lys Tyr Leu Glu Glu Ile Ala Thr Gln Met Arg 
                485                 490                 495     


Thr His Ser Ile Asn Ala Leu Leu Ile Ile Gly Gly Phe Glu Ala Tyr 
            500                 505                 510         


Leu Gly Leu Leu Glu Leu Ser Ala Ala Arg Glu Lys His Glu Glu Phe 
        515                 520                 525             


Cys Val Pro Met Val Met Val Pro Ala Thr Val Ser Asn Asn Val Pro 
    530                 535                 540                 


Gly Ser Asp Phe Ser Ile Gly Ala Asp Thr Ala Leu Asn Thr Ile Thr 
545                 550                 555                 560 


Asp Thr Cys Asp Arg Ile Lys Gln Ser Ala Ser Gly Thr Lys Arg Arg 
                565                 570                 575     


Val Phe Ile Ile Glu Thr Met Gly Gly Tyr Cys Gly Tyr Leu Ala Asn 
            580                 585                 590         


Met Gly Gly Leu Ala Ala Gly Ala Asp Ala Ala Tyr Ile Phe Glu Glu 
        595                 600                 605             


Pro Phe Asp Ile Arg Asp Leu Gln Ser Asn Val Glu His Leu Thr Glu 
    610                 615                 620                 


Lys Met Lys Thr Thr Ile Gln Arg Gly Leu Val Leu Arg Asn Glu Ser 
625                 630                 635                 640 


Cys Ser Glu Asn Tyr Thr Thr Asp Phe Ile Tyr Gln Leu Tyr Ser Glu 
                645                 650                 655     


Glu Gly Lys Gly Val Phe Asp Cys Arg Lys Asn Val Leu Gly His Met 
            660                 665                 670         


Gln Gln Gly Gly Ala Pro Ser Pro Phe Asp Arg Asn Phe Gly Thr Lys 
        675                 680                 685             


Ile Ser Ala Arg Ala Met Glu Trp Ile Thr Ala Lys Leu Lys Glu Ala 
    690                 695                 700                 


Arg Gly Arg Gly Lys Lys Phe Thr Thr Asp Asp Ser Ile Cys Val Leu 
705                 710                 715                 720 


Gly Ile Ser Lys Arg Asn Val Ile Phe Gln Pro Val Ala Glu Leu Lys 
                725                 730                 735     


Lys Gln Thr Asp Phe Glu His Arg Ile Pro Lys Glu Gln Trp Trp Leu 
            740                 745                 750         


Lys Leu Arg Pro Leu Met Lys Ile Leu Ala Lys Tyr Lys Ala Ser Tyr 
        755                 760                 765             


Asp Val Ser Asp Ser Gly Gln Leu Glu His Val Gln Pro Trp Ser Val 
    770                 775                 780                 


<210>  2695
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  2695

Met Ala Gly Trp Gln Ser Tyr Val Asp Asn Leu Met Cys Asp Gly Cys 
1               5                   10                  15      


Cys Gln Glu Ala Ala Ile Val Gly Tyr Cys Asp Ala Lys Tyr Val Trp 
            20                  25                  30          


Ala Ala Thr Ala Gly Gly Val Phe Gln Ser Ile Thr Pro Ile Glu Ile 
        35                  40                  45              


Asp Met Ile Val Gly Lys Asp Arg Glu Gly Phe Phe Thr Asn Gly Leu 
    50                  55                  60                  


Thr Leu Gly Ala Lys Lys Cys Ser Val Ile Arg Asp Ser Leu Tyr Val 
65                  70                  75                  80  


Asp Gly Asp Cys Thr Met Asp Ile Arg Thr Lys Ser Gln Gly Gly Glu 
                85                  90                  95      


Pro Thr Tyr Asn Val Ala Val Gly Arg Ala Gly Arg Ala Leu Val Ile 
            100                 105                 110         


Val Met Gly Lys Glu Gly Val His Gly Gly Thr Leu Asn Lys Lys Ala 
        115                 120                 125             


Tyr Glu Leu Ala Leu Tyr Leu Arg Arg Ser Asp Val 
    130                 135                 140 


<210>  2696
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  2696

Met Phe Ser Ser Val Ala His Leu Ala Arg Ala Asn Pro Phe Asn Thr 
1               5                   10                  15      


Pro His Leu Gln Leu Val His Asp Gly Leu Gly Asp Leu Arg Ser Ser 
            20                  25                  30          


Ser Pro Gly Pro Thr Gly Gln Pro Arg Arg Pro Arg Asn Leu Ala Ala 
        35                  40                  45              


Ala Ala Val Glu Glu Tyr Ser Cys Glu Phe Gly Ser Ala Lys Tyr Tyr 
    50                  55                  60                  


Ala Leu Cys Gly Phe Gly Gly Val Leu Ser Cys Gly Leu Thr His Thr 
65                  70                  75                  80  


Ala Val Val Pro Leu Asp Leu Val Lys Cys Arg Met Gln Val Asp Pro 
                85                  90                  95      


Gln Lys Tyr Lys Gly Ile Phe Asn Gly Phe Ser Val Thr Leu Lys Glu 
            100                 105                 110         


Asp Gly Val Arg Gly Leu Ala Lys Gly Trp Ala Pro Thr Phe Leu Gly 
        115                 120                 125             


Tyr Ser Met Gln Gly Leu Cys Lys Phe Gly Phe Tyr Glu Val Phe Lys 
    130                 135                 140                 


Val Leu Tyr Ser Asn Met Leu Gly Glu Glu Asn Thr Tyr Leu Trp Arg 
145                 150                 155                 160 


Thr Ser Leu Tyr Leu Ala Ala Ser Ala Ser Ala Glu Phe Phe Ala Asp 
                165                 170                 175     


Ile Ala Leu Ala Pro Met Glu Ala Ala Lys Val Arg Ile Gln Thr Gln 
            180                 185                 190         


Pro Gly Tyr Ala Asn Thr Leu Arg Asp Ala Ala Pro Lys Met Tyr Lys 
        195                 200                 205             


Glu Glu Gly Leu Lys Ala Phe Tyr Lys Gly Val Ala Pro Leu Trp Met 
    210                 215                 220                 


Arg Gln Ile Pro Tyr Thr Met Met Lys Phe Ala Cys Phe Glu Arg Thr 
225                 230                 235                 240 


Val Glu Ala Leu Tyr Lys Phe Val Val Pro Lys Pro Arg Ser Glu Cys 
                245                 250                 255     


Ser Lys Pro Glu Gln Leu Val Val Thr Phe Val Ala Gly Tyr Ile Ala 
            260                 265                 270         


Gly Val Phe Cys Ala Ile Val Ser His Pro Ala Asp Ser Val Val Ser 
        275                 280                 285             


Val Leu Asn Lys Glu Lys Gly Ser Ser Ala Ser Leu Val Leu Lys Arg 
    290                 295                 300                 


Leu Gly Phe Lys Gly Val Trp Lys Gly Leu Phe Ala Arg Ile Ile Met 
305                 310                 315                 320 


Ile Gly Thr Leu Thr Ala Leu Gln Trp Phe Ile Tyr Asp Ser Val Lys 
                325                 330                 335     


Val Tyr Phe Arg Leu Pro Arg Pro Pro Pro Pro Glu Met Pro Glu Ser 
            340                 345                 350         


Leu Lys Lys Lys Leu Gly Leu Thr Gln 
        355                 360     


<210>  2697
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  2697

Met Arg Ala Ser Ser Phe Leu Ile Val Val Val Phe Leu Ile Ala Gly 
1               5                   10                  15      


Thr Leu Val Leu Glu Ala Ala Val Thr Gly Val Pro Val Lys Gly Gln 
            20                  25                  30          


Asp Thr Val Lys Gly Arg Val Pro Phe Asn Gly Gln Asp Pro Val Lys 
        35                  40                  45              


Gly Gln Val Ser Val Lys Gly Gln Asp Lys Val Lys Ala Gln Glu Pro 
    50                  55                  60                  


Val Lys Gly Pro Val Ser Thr Lys Pro Gly Ser Cys Pro Ile Ile Leu 
65                  70                  75                  80  


Ile Arg Cys Ala Met Leu Asn Pro Pro Asn Arg Cys Leu Lys Asp Thr 
                85                  90                  95      


Asp Cys Pro Gly Ile Lys Lys Cys Cys Glu Gly Ser Cys Gly Met Ala 
            100                 105                 110         


Cys Phe Val Pro Gln 
        115         


<210>  2698
<211>  484
<212>  PRT
<213>  Homo sapiens

<400>  2698

Met Ala Cys Arg Gly Gly Ala Gly Asn Gly His Arg Ala Ser Ala Thr 
1               5                   10                  15      


Leu Ser Arg Val Ser Pro Gly Ser Leu Tyr Thr Cys Arg Thr Arg Thr 
            20                  25                  30          


His Asn Ile Cys Met Val Ser Asp Phe Phe Tyr Pro Asn Met Gly Gly 
        35                  40                  45              


Val Glu Ser His Ile Tyr Gln Leu Ser Gln Cys Leu Ile Glu Arg Gly 
    50                  55                  60                  


His Lys Val Ile Ile Val Thr His Ala Tyr Gly Asn Arg Lys Gly Ile 
65                  70                  75                  80  


Arg Tyr Leu Thr Ser Gly Leu Lys Val Tyr Tyr Leu Pro Leu Lys Val 
                85                  90                  95      


Met Tyr Asn Gln Ser Thr Ala Thr Thr Leu Phe His Ser Leu Pro Leu 
            100                 105                 110         


Leu Arg Tyr Ile Phe Val Arg Glu Arg Val Thr Ile Ile His Ser His 
        115                 120                 125             


Ser Ser Phe Ser Ala Met Ala His Asp Ala Leu Phe His Ala Lys Thr 
    130                 135                 140                 


Met Gly Leu Gln Thr Val Phe Thr Asp His Ser Leu Phe Gly Phe Ala 
145                 150                 155                 160 


Asp Val Ser Ser Val Leu Thr Asn Lys Leu Leu Thr Val Ser Leu Cys 
                165                 170                 175     


Asp Thr Asn His Ile Ile Cys Val Ser Tyr Thr Ser Lys Glu Asn Thr 
            180                 185                 190         


Val Leu Arg Ala Ala Leu Asn Pro Glu Ile Val Ser Val Ile Pro Asn 
        195                 200                 205             


Ala Val Asp Pro Thr Asp Phe Thr Pro Asp Pro Phe Arg Arg His Asp 
    210                 215                 220                 


Ser Ile Thr Ile Val Val Val Ser Arg Leu Val Tyr Arg Lys Gly Ile 
225                 230                 235                 240 


Asp Leu Leu Ser Gly Ile Ile Pro Glu Leu Cys Gln Lys Tyr Pro Asp 
                245                 250                 255     


Leu Asn Phe Ile Ile Gly Gly Glu Gly Pro Lys Arg Ile Ile Leu Glu 
            260                 265                 270         


Glu Val Arg Glu Arg Tyr Gln Leu His Asp Arg Val Arg Leu Leu Gly 
        275                 280                 285             


Ala Leu Glu His Lys Asp Val Arg Asn Val Leu Val Gln Gly His Ile 
    290                 295                 300                 


Phe Leu Asn Thr Ser Leu Thr Glu Ala Phe Cys Met Ala Ile Val Glu 
305                 310                 315                 320 


Ala Ala Ser Cys Gly Leu Gln Val Val Ser Thr Arg Val Gly Gly Ile 
                325                 330                 335     


Pro Glu Val Leu Pro Glu Asn Leu Ile Ile Leu Cys Glu Pro Ser Val 
            340                 345                 350         


Lys Ser Leu Cys Glu Gly Leu Glu Lys Ala Ile Phe Gln Leu Lys Ser 
        355                 360                 365             


Gly Thr Leu Pro Ala Pro Glu Asn Ile His Asn Ile Val Lys Thr Phe 
    370                 375                 380                 


Tyr Thr Trp Arg Asn Val Ala Glu Arg Thr Glu Lys Val Tyr Asp Arg 
385                 390                 395                 400 


Val Ser Val Glu Ala Val Leu Pro Met Asp Lys Arg Leu Asp Arg Leu 
                405                 410                 415     


Ile Ser His Cys Gly Pro Val Thr Gly Tyr Ile Phe Ala Leu Leu Ala 
            420                 425                 430         


Val Phe Asn Phe Leu Phe Leu Ile Phe Leu Arg Trp Met Thr Pro Asp 
        435                 440                 445             


Ser Ile Ile Asp Val Ala Ile Asp Ala Thr Gly Pro Arg Gly Ala Trp 
    450                 455                 460                 


Thr Asn Asn Tyr Ser His Ser Lys Arg Gly Gly Glu Asn Asn Glu Ile 
465                 470                 475                 480 


Ser Glu Thr Arg 
                


<210>  2699
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  2699

Met Tyr Ala Gln Pro Val Thr Asn Thr Lys Glu Val Lys Trp Gln Lys 
1               5                   10                  15      


Val Leu Tyr Glu Arg Gln Pro Phe Pro Asp Asn Tyr Val Asp Arg Arg 
            20                  25                  30          


Phe Leu Glu Glu Leu Arg Lys Asn Ile His Ala Arg Lys Tyr Gln Tyr 
        35                  40                  45              


Trp Ala Val Val Phe Glu Ser Ser Val Val Ile Gln Gln Leu Cys Ser 
    50                  55                  60                  


Val Cys Val Phe Val Val Ile Trp Trp Tyr Met Asp Glu Gly Leu Leu 
65                  70                  75                  80  


Ala Pro His Trp Leu Leu Gly Thr Gly Leu Ala Ser Ser Leu Ile Gly 
                85                  90                  95      


Tyr Val Leu Phe Asp Leu Ile Asp Gly Gly Glu Gly Arg Lys Lys Ser 
            100                 105                 110         


Gly Gln Thr Arg Trp Ala Asp Leu Lys Ser Ala Leu Val Phe Ile Thr 
        115                 120                 125             


Phe Thr Tyr Gly Phe Ser Pro Val Leu Lys Thr Leu Thr Glu Ser Val 
    130                 135                 140                 


Ser Thr Asp Thr Ile Tyr Ala Met Ser Val Phe Met Leu Leu Gly His 
145                 150                 155                 160 


Leu Ile Phe Phe Asp Tyr Gly Ala Asn Ala Ala Ile Val Ser Ser Thr 
                165                 170                 175     


Leu Ser Leu Asn Met Ala Ile Phe Ala Ser Val Cys Leu Ala Ser Arg 
            180                 185                 190         


Leu Pro Arg Ser Leu His Ala Phe Ile Met Val Thr Phe Ala Ile Gln 
        195                 200                 205             


Ile Phe Ala Leu Trp Pro Met Leu Gln Lys Lys Leu Lys Ala Cys Thr 
    210                 215                 220                 


Pro Arg Ser Tyr Val Gly Val Thr Leu Leu Phe Ala Phe Ser Ala Val 
225                 230                 235                 240 


Gly Gly Leu Leu Ser Ile Ser Ala Val Gly Ala Val Leu Phe Ala Leu 
                245                 250                 255     


Leu Leu Met Ser Ile Ser Cys Leu Cys Pro Phe Tyr Leu Ile Arg Leu 
            260                 265                 270         


Gln Leu Phe Lys Glu Asn Ile His Gly Pro Trp Asp Glu Ala Glu Ile 
        275                 280                 285             


Lys Glu Asp Leu Ser Arg Phe Leu Ser 
    290                 295         


<210>  2700
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  2700

Met Lys Asp Asn Asp Ile Lys Arg Leu Leu Tyr Thr His Leu Leu Cys 
1               5                   10                  15      


Ile Phe Ser Ile Ile Leu Ser Val Phe Ile Pro Ser Leu Phe Leu Glu 
            20                  25                  30          


Asn Phe Ser Ile Leu Glu Thr His Leu Thr Trp Leu Cys Ile Cys Ser 
        35                  40                  45              


Gly Phe Val Thr Ala Val Asn Leu Val Leu Tyr Leu Val Val Lys Pro 
    50                  55                  60                  


Asn Thr Ser Ser Lys Arg Ser Ser Leu Ser His Lys Val Thr Gly Phe 
65                  70                  75                  80  


Leu Lys Cys Cys Ile Tyr Phe Leu Met Ser Cys Phe Ser Phe His Val 
                85                  90                  95      


Ile Phe Val Leu Tyr Gly Ala Pro Leu Ile Glu Leu Ala Leu Glu Thr 
            100                 105                 110         


Phe Leu Phe Ala Val Ile Leu Ser Thr Phe Thr Thr Val Pro Cys Leu 
        115                 120                 125             


Cys Leu Leu Gly Pro Asn Leu Lys Ala Trp Leu Arg Val Phe Ser Arg 
    130                 135                 140                 


Asn Gly Val Thr Ser Ile Trp Glu Asn Ser Leu Gln Ile Thr Thr Ile 
145                 150                 155                 160 


Ser Ser Phe Val Gly Ala Trp Leu Gly Ala Leu Pro Ile Pro Leu Asp 
                165                 170                 175     


Trp Glu Arg Pro Trp Gln Val Trp Pro Ile Ser Cys Thr Leu Gly Ala 
            180                 185                 190         


Thr Phe Gly Tyr Val Ala Gly Leu Val Ile Ser Pro Leu Trp Ile Tyr 
        195                 200                 205             


Trp Asn Arg Lys Gln Leu Thr Tyr Lys Asn Asn 
    210                 215                 


<210>  2701
<211>  764
<212>  PRT
<213>  Homo sapiens

<400>  2701

Met Leu Leu Phe Val Leu Thr Cys Leu Leu Ala Val Phe Pro Ala Ile 
1               5                   10                  15      


Ser Thr Lys Ser Pro Ile Phe Gly Pro Glu Glu Val Asn Ser Val Glu 
            20                  25                  30          


Gly Asn Ser Val Ser Ile Thr Cys Tyr Tyr Pro Pro Thr Ser Val Asn 
        35                  40                  45              


Arg His Thr Arg Lys Tyr Trp Cys Arg Gln Gly Ala Arg Gly Gly Cys 
    50                  55                  60                  


Ile Thr Leu Ile Ser Ser Glu Gly Tyr Val Ser Ser Lys Tyr Ala Gly 
65                  70                  75                  80  


Arg Ala Asn Leu Thr Asn Phe Pro Glu Asn Gly Thr Phe Val Val Asn 
                85                  90                  95      


Ile Ala Gln Leu Ser Gln Asp Asp Ser Gly Arg Tyr Lys Cys Gly Leu 
            100                 105                 110         


Gly Ile Asn Ser Arg Gly Leu Ser Phe Asp Val Ser Leu Glu Val Ser 
        115                 120                 125             


Gln Gly Pro Gly Leu Leu Asn Asp Thr Lys Val Tyr Thr Val Asp Leu 
    130                 135                 140                 


Gly Arg Thr Val Thr Ile Asn Cys Pro Phe Lys Thr Glu Asn Ala Gln 
145                 150                 155                 160 


Lys Arg Lys Ser Leu Tyr Lys Gln Ile Gly Leu Tyr Pro Val Leu Val 
                165                 170                 175     


Ile Asp Ser Ser Gly Tyr Val Asn Pro Asn Tyr Thr Gly Arg Ile Arg 
            180                 185                 190         


Leu Asp Ile Gln Gly Thr Gly Gln Leu Leu Phe Ser Val Val Ile Asn 
        195                 200                 205             


Gln Leu Arg Leu Ser Asp Ala Gly Gln Tyr Leu Cys Gln Ala Gly Asp 
    210                 215                 220                 


Asp Ser Asn Ser Asn Lys Lys Asn Ala Asp Leu Gln Val Leu Lys Pro 
225                 230                 235                 240 


Glu Pro Glu Leu Val Tyr Glu Asp Leu Arg Gly Ser Val Thr Phe His 
                245                 250                 255     


Cys Ala Leu Gly Pro Glu Val Ala Asn Val Ala Lys Phe Leu Cys Arg 
            260                 265                 270         


Gln Ser Ser Gly Glu Asn Cys Asp Val Val Val Asn Thr Leu Gly Lys 
        275                 280                 285             


Arg Ala Pro Ala Phe Glu Gly Arg Ile Leu Leu Asn Pro Gln Asp Lys 
    290                 295                 300                 


Asp Gly Ser Phe Ser Val Val Ile Thr Gly Leu Arg Lys Glu Asp Ala 
305                 310                 315                 320 


Gly Arg Tyr Leu Cys Gly Ala His Ser Asp Gly Gln Leu Gln Glu Gly 
                325                 330                 335     


Ser Pro Ile Gln Ala Trp Gln Leu Phe Val Asn Glu Glu Ser Thr Ile 
            340                 345                 350         


Pro Arg Ser Pro Thr Val Val Lys Gly Val Ala Gly Gly Ser Val Ala 
        355                 360                 365             


Val Leu Cys Pro Tyr Asn Arg Lys Glu Ser Lys Ser Ile Lys Tyr Trp 
    370                 375                 380                 


Cys Leu Trp Glu Gly Ala Gln Asn Gly Arg Cys Pro Leu Leu Val Asp 
385                 390                 395                 400 


Ser Glu Gly Trp Val Lys Ala Gln Tyr Glu Gly Arg Leu Ser Leu Leu 
                405                 410                 415     


Glu Glu Pro Gly Asn Gly Thr Phe Thr Val Ile Leu Asn Gln Leu Thr 
            420                 425                 430         


Ser Arg Asp Ala Gly Phe Tyr Trp Cys Leu Thr Asn Gly Asp Thr Leu 
        435                 440                 445             


Trp Arg Thr Thr Val Glu Ile Lys Ile Ile Glu Gly Glu Pro Asn Leu 
    450                 455                 460                 


Lys Val Pro Gly Asn Val Thr Ala Val Leu Gly Glu Thr Leu Lys Val 
465                 470                 475                 480 


Pro Cys His Phe Pro Cys Lys Phe Ser Ser Tyr Glu Lys Tyr Trp Cys 
                485                 490                 495     


Lys Trp Asn Asn Thr Gly Cys Gln Ala Leu Pro Ser Gln Asp Glu Gly 
            500                 505                 510         


Pro Ser Lys Ala Phe Val Asn Cys Asp Glu Asn Ser Arg Leu Val Ser 
        515                 520                 525             


Leu Thr Leu Asn Leu Val Thr Arg Ala Asp Glu Gly Trp Tyr Trp Cys 
    530                 535                 540                 


Gly Val Lys Gln Gly His Phe Tyr Gly Glu Thr Ala Ala Val Tyr Val 
545                 550                 555                 560 


Ala Val Glu Glu Arg Lys Ala Ala Gly Ser Arg Asp Val Ser Leu Ala 
                565                 570                 575     


Lys Ala Asp Ala Ala Pro Asp Glu Lys Val Leu Asp Ser Gly Phe Arg 
            580                 585                 590         


Glu Ile Glu Asn Lys Ala Ile Gln Asp Pro Arg Leu Phe Ala Glu Glu 
        595                 600                 605             


Lys Ala Val Ala Asp Thr Arg Asp Gln Ala Asp Gly Ser Arg Ala Ser 
    610                 615                 620                 


Val Asp Ser Gly Ser Ser Glu Glu Gln Gly Gly Ser Ser Arg Ala Leu 
625                 630                 635                 640 


Val Ser Thr Leu Val Pro Leu Gly Leu Val Leu Ala Val Gly Ala Val 
                645                 650                 655     


Ala Val Gly Val Ala Arg Ala Arg His Arg Lys Asn Val Asp Arg Val 
            660                 665                 670         


Ser Ile Arg Ser Tyr Arg Thr Asp Ile Ser Met Ser Asp Phe Glu Asn 
        675                 680                 685             


Ser Arg Glu Phe Gly Ala Asn Asp Asn Met Gly Ala Ser Ser Ile Thr 
    690                 695                 700                 


Gln Glu Thr Ser Leu Gly Gly Lys Glu Glu Phe Val Ala Thr Thr Glu 
705                 710                 715                 720 


Ser Thr Thr Glu Thr Lys Glu Pro Lys Lys Ala Lys Arg Ser Ser Lys 
                725                 730                 735     


Glu Glu Ala Glu Met Ala Tyr Lys Asp Phe Leu Leu Gln Ser Ser Thr 
            740                 745                 750         


Val Ala Ala Glu Ala Gln Asp Gly Pro Gln Glu Ala 
        755                 760                 


<210>  2702
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  2702

Met Ala Val Asn Lys Gly Leu Thr Leu Leu Asp Gly Asp Leu Pro Glu 
1               5                   10                  15      


Gln Glu Asn Val Leu Gln Arg Val Leu Gln Leu Pro Val Val Ser Gly 
            20                  25                  30          


Thr Cys Glu Cys Phe Gln Lys Thr Tyr Thr Ser Thr Lys Glu Ala His 
        35                  40                  45              


Pro Leu Val Ala Ser Val Cys Asn Ala Tyr Glu Lys Gly Val Gln Ser 
    50                  55                  60                  


Ala Ser Ser Leu Ala Ala Trp Ser Met Glu Pro Val Val Arg Arg Leu 
65                  70                  75                  80  


Ser Thr Gln Phe Thr Ala Ala Asn Glu Leu Ala Cys Arg Gly Leu Asp 
                85                  90                  95      


His Leu Glu Glu Lys Ile Pro Ala Leu Gln Tyr Pro Pro Glu Lys Ile 
            100                 105                 110         


Ala Ser Glu Leu Lys Asp Thr Ile Ser Thr Arg Leu Arg Ser Ala Arg 
        115                 120                 125             


Asn Ser Ile Ser Val Pro Ile Ala Ser Thr Ser Asp Lys Val Leu Gly 
    130                 135                 140                 


Ala Ala Leu Ala Gly Cys Glu Leu Ala Trp Gly Val Ala Arg Asp Thr 
145                 150                 155                 160 


Ala Glu Phe Ala Ala Asn Thr Arg Ala Gly Arg Leu Ala Ser Gly Gly 
                165                 170                 175     


Ala Asp Leu Ala Leu Gly Ser Ile Glu Lys Val Val Glu Tyr Leu Leu 
            180                 185                 190         


Pro Pro Asp Lys Glu Glu Ser Ala Pro Ala Pro Gly His Gln Gln Ala 
        195                 200                 205             


Gln Lys Ser Pro Lys Ala Lys Pro Ser Leu Leu Ser Arg Val Gly Ala 
    210                 215                 220                 


Leu Thr Asn Thr Leu Ser Arg Tyr Thr Val Gln Thr Met Ala Arg Ala 
225                 230                 235                 240 


Leu Glu Gln Gly His Thr Val Ala Met Trp Ile Pro Gly Val Val Pro 
                245                 250                 255     


Leu Ser Ser Leu Ala Gln Trp Gly Ala Ser Val Ala Met Gln Ala Val 
            260                 265                 270         


Ser Arg Arg Arg Ser Glu Val Arg Val Pro Trp Leu His Ser Leu Ala 
        275                 280                 285             


Ala Ala Gln Glu Glu Asp His Glu Asp Gln Thr Asp Thr Glu Gly Glu 
    290                 295                 300                 


Asp Thr Glu Glu Glu Glu Glu Leu Glu Thr Glu Glu Asn Lys Phe Ser 
305                 310                 315                 320 


Glu Val Ala Ala Leu Pro Gly Pro Arg Gly Leu Leu Gly Gly Val Ala 
                325                 330                 335     


His Thr Leu Gln Lys Thr Leu Gln Thr Thr Ile Ser Ala Val Thr Trp 
            340                 345                 350         


Ala Pro Ala Ala Val Leu Gly Met Ala Gly Arg Val Leu His Leu Thr 
        355                 360                 365             


Pro Ala Pro Ala Val Ser Ser Thr Lys Gly Arg Ala Met Ser Leu Ser 
    370                 375                 380                 


Asp Ala Leu Lys Gly Val Thr Asp Asn Val Val Asp Thr Val Val His 
385                 390                 395                 400 


Tyr Val Pro Leu Pro Arg Leu Ser Leu Met Glu Pro Glu Ser Glu Phe 
                405                 410                 415     


Arg Asp Ile Asp Asn Pro Pro Ala Glu Val Glu Arg Arg Glu Ala Glu 
            420                 425                 430         


Arg Arg Ala Ser Gly Ala Pro Ser Ala Gly Pro Glu Pro Ala Pro Arg 
        435                 440                 445             


Leu Ala Gln Pro Arg Arg Ser Leu Arg Ser Ala Gln Ser Pro Gly Ala 
    450                 455                 460                 


Pro Pro Gly Pro Gly Leu Glu Asp Glu Val Ala Thr Pro Ala Ala Pro 
465                 470                 475                 480 


Arg Pro Gly Phe Pro Ala Val Pro Arg Glu Lys Pro Lys Arg Arg Val 
                485                 490                 495     


Ser Asp Ser Phe Phe Arg Pro Ser Val Met Glu Pro Ile Leu Gly Arg 
            500                 505                 510         


Thr His Tyr Ser Gln Leu Arg Lys Lys Ser 
        515                 520         


<210>  2703
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  2703

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Ser 
1               5                   10                  15      


Thr Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn Leu Phe 
            20                  25                  30          


Ile Asn Phe Cys Leu Ile Leu Ile Cys Leu Leu Leu Ile Cys Ile Ile 
        35                  40                  45              


Val Met Leu Leu 
    50          


<210>  2704
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  2704

Met Ala Asp Ser Glu Arg Leu Ser Ala Pro Gly Cys Trp Ala Ala Cys 
1               5                   10                  15      


Thr Asn Phe Ser Arg Thr Arg Lys Gly Ile Leu Leu Phe Ala Glu Ile 
            20                  25                  30          


Ile Leu Cys Leu Val Ile Leu Ile Cys Phe Ser Ala Ser Thr Pro Gly 
        35                  40                  45              


Tyr Ser Ser Leu Ser Val Ile Glu Met Ile Leu Ala Ala Ile Phe Phe 
    50                  55                  60                  


Val Val Tyr Met Cys Asp Leu His Thr Lys Ile Pro Phe Ile Asn Trp 
65                  70                  75                  80  


Pro Trp Ser Asp Phe Phe Arg Thr Leu Ile Ala Ala Ile Leu Tyr Leu 
                85                  90                  95      


Ile Thr Ser Ile Val Val Leu Val Glu Arg Gly Asn His Ser Lys Ile 
            100                 105                 110         


Val Ala Gly Val Leu Gly Leu Ile Ala Thr Cys Leu Phe Gly Tyr Asp 
        115                 120                 125             


Ala Tyr Val Thr Phe Pro Val Arg Gln Pro Arg His Thr Ala Ala Pro 
    130                 135                 140                 


Thr Asp Pro Ala Asp Gly Pro Val 
145                 150         


<210>  2705
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  2705

Met Ser Leu Arg Leu Asp Thr Thr Pro Ser Cys Asn Ser Ala Arg Pro 
1               5                   10                  15      


Leu His Ala Leu Gln Val Leu Leu Leu Leu Ser Leu Leu Leu Thr Ala 
            20                  25                  30          


Leu Ala Ser Ser Thr Lys Gly Gln Thr Lys Arg Asn Leu Ala Lys Gly 
        35                  40                  45              


Lys Glu Glu Ser Leu Asp Ser Asp Leu Tyr Ala Glu Leu Arg Cys Met 
    50                  55                  60                  


Cys Ile Lys Thr Thr Ser Gly Ile His Pro Lys Asn Ile Gln Ser Leu 
65                  70                  75                  80  


Glu Val Ile Gly Lys Gly Thr His Cys Asn Gln Val Glu Val Ile Ala 
                85                  90                  95      


Thr Leu Lys Asp Gly Arg Lys Ile Cys Leu Asp Pro Asp Ala Pro Arg 
            100                 105                 110         


Ile Lys Lys Ile Val Gln Lys Lys Leu Ala Gly Asp Glu Ser Ala Asp 
        115                 120                 125             


<210>  2706
<211>  1122
<212>  PRT
<213>  Homo sapiens

<400>  2706

Met Glu Pro Ser Glu Val Pro Ser Gln Ile Ser Lys Asp Asn Phe Leu 
1               5                   10                  15      


Glu Val Pro Asn Leu Ser Asp Ser Leu Cys Glu Asp Glu Glu Val Thr 
            20                  25                  30          


Phe Gln Pro Gly Phe Ser Pro Gln Pro Ser Arg Arg Gly Ser Asp Ser 
        35                  40                  45              


Ser Glu Asp Ile Tyr Leu Asp Thr Pro Ser Ser Gly Thr Arg Arg Val 
    50                  55                  60                  


Ser Phe Ala Asp Ser Phe Gly Phe Asn Leu Val Ser Val Lys Glu Phe 
65                  70                  75                  80  


Asp Cys Trp Glu Leu Pro Ser Ala Ser Thr Thr Phe Asp Leu Gly Thr 
                85                  90                  95      


Asp Ile Phe His Thr Glu Glu Tyr Val Leu Ala Pro Leu Phe Asp Leu 
            100                 105                 110         


Pro Ser Ser Lys Glu Asp Leu Met Gln Gln Leu Gln Ile Gln Lys Ala 
        115                 120                 125             


Ile Leu Glu Ser Thr Glu Ser Leu Leu Gly Ser Thr Ser Ile Lys Gly 
    130                 135                 140                 


Ile Ile Arg Val Leu Asn Val Ser Phe Glu Lys Leu Val Tyr Val Arg 
145                 150                 155                 160 


Met Ser Leu Asp Asp Trp Gln Thr His Tyr Asp Ile Leu Ala Glu Tyr 
                165                 170                 175     


Val Pro Asn Ser Cys Asp Gly Glu Thr Asp Gln Phe Ser Phe Lys Ile 
            180                 185                 190         


Val Leu Val Pro Pro Tyr Gln Lys Asp Gly Ser Lys Val Glu Phe Cys 
        195                 200                 205             


Ile Arg Tyr Glu Thr Ser Val Gly Thr Phe Trp Ser Asn Asn Asn Gly 
    210                 215                 220                 


Thr Asn Tyr Thr Phe Ile Cys Gln Lys Lys Glu Gln Glu Pro Glu Pro 
225                 230                 235                 240 


Val Lys Pro Trp Lys Glu Val Pro Asn Arg Gln Ile Lys Gly Cys Leu 
                245                 250                 255     


Lys Val Lys Ser Ser Lys Glu Glu Ser Ser Val Thr Ser Glu Glu Asn 
            260                 265                 270         


Asn Phe Glu Asn Pro Lys Asn Thr Asp Thr Tyr Ile Pro Thr Ile Ile 
        275                 280                 285             


Cys Ser His Glu Asp Lys Glu Asp Leu Glu Ala Ser Asn Arg Asn Val 
    290                 295                 300                 


Lys Asp Val Asn Arg Glu His Asp Glu His Asn Glu Lys Glu Leu Glu 
305                 310                 315                 320 


Leu Met Ile Asn Gln His Leu Ile Arg Thr Arg Ser Thr Ala Ser Arg 
                325                 330                 335     


Asp Glu Arg Asn Thr Phe Ser Thr Asp Pro Val Asn Phe Pro Asn Lys 
            340                 345                 350         


Ala Glu Gly Leu Glu Lys Lys Gln Ile His Gly Glu Ile Cys Thr Asp 
        355                 360                 365             


Leu Phe Gln Arg Ser Leu Ser Pro Ser Ser Ser Ala Glu Ser Ser Val 
    370                 375                 380                 


Lys Gly Asp Phe Tyr Cys Asn Glu Lys Tyr Ser Ser Gly Asp Asp Cys 
385                 390                 395                 400 


Thr His Gln Pro Ser Glu Glu Thr Thr Ser Asn Met Gly Glu Ile Lys 
                405                 410                 415     


Pro Ser Leu Gly Asp Thr Ser Ser Asp Glu Leu Val Gln Leu His Thr 
            420                 425                 430         


Gly Ser Lys Glu Val Leu Asp Asp Asn Ala Asn Pro Ala His Gly Asn 
        435                 440                 445             


Gly Thr Val Gln Ile Pro Cys Pro Ser Ser Asp Gln Leu Met Ala Gly 
    450                 455                 460                 


Asn Leu Asn Lys Lys His Glu Gly Gly Ala Lys Asn Ile Glu Val Lys 
465                 470                 475                 480 


Asp Leu Gly Cys Leu Arg Arg Asp Phe His Ser Asp Thr Ser Ala Cys 
                485                 490                 495     


Leu Lys Glu Ser Thr Glu Glu Gly Ser Ser Lys Glu Asp Tyr Tyr Gly 
            500                 505                 510         


Asn Gly Lys Asp Asp Glu Glu Gln Arg Ile Tyr Leu Gly Val Asn Glu 
        515                 520                 525             


Lys Gln Arg Lys Asn Phe Gln Thr Ile Leu His Asp Gln Glu Arg Lys 
    530                 535                 540                 


Met Gly Asn Pro Lys Ile Ser Val Ala Gly Ile Gly Ala Ser Asn Arg 
545                 550                 555                 560 


Asp Leu Ala Thr Leu Leu Ser Glu His Thr Ala Ile Pro Thr Arg Ala 
                565                 570                 575     


Ile Thr Ala Asp Val Ser His Ser Pro Arg Thr Asn Leu Ser Trp Glu 
            580                 585                 590         


Glu Ala Val Leu Thr Pro Glu His His His Leu Thr Ser Glu Gly Ser 
        595                 600                 605             


Ala Leu Gly Gly Ile Thr Gly Gln Val Cys Ser Ser Arg Thr Gly Asn 
    610                 615                 620                 


Val Leu Arg Asn Asp Tyr Leu Phe Gln Val Glu Glu Lys Ser Gly Gly 
625                 630                 635                 640 


Ile Asn Ser Glu Asp Gln Asp Asn Ser Pro Gln His Lys Gln Ser Trp 
                645                 650                 655     


Asn Val Leu Glu Ser Gln Gly Lys Ser Arg Glu Asn Lys Thr Asn Ile 
            660                 665                 670         


Thr Glu His Ile Lys Gly Gln Thr Asp Cys Glu Asp Val Trp Gly Lys 
        675                 680                 685             


Arg Asp Asn Thr Arg Ser Leu Lys Ala Thr Thr Glu Glu Leu Phe Thr 
    690                 695                 700                 


Cys Gln Glu Thr Val Cys Cys Glu Leu Ser Ser Leu Ala Asp His Gly 
705                 710                 715                 720 


Ile Thr Glu Lys Ala Glu Ala Gly Thr Ala Tyr Ile Ile Lys Thr Thr 
                725                 730                 735     


Ser Glu Ser Thr Pro Glu Ser Met Ser Ala Arg Glu Lys Ala Ile Ile 
            740                 745                 750         


Ala Lys Leu Pro Gln Glu Thr Ala Arg Ser Asp Arg Pro Ile Glu Val 
        755                 760                 765             


Lys Glu Thr Ala Phe Asp Pro His Glu Gly Arg Asn Asp Asp Ser His 
    770                 775                 780                 


Tyr Thr Leu Cys Gln Arg Asp Thr Val Gly Val Ile Tyr Asp Asn Asp 
785                 790                 795                 800 


Phe Glu Lys Glu Ser Arg Leu Gly Ile Cys Asn Val Arg Val Asp Glu 
                805                 810                 815     


Met Glu Lys Glu Glu Thr Met Ser Met Tyr Asn Pro Arg Lys Thr His 
            820                 825                 830         


Asp Arg Glu Lys Cys Gly Thr Gly Asn Ile Thr Ser Val Glu Glu Ser 
        835                 840                 845             


Ser Trp Val Ile Thr Glu Tyr Gln Lys Ala Thr Ser Lys Leu Asp Leu 
    850                 855                 860                 


Gln Leu Gly Met Leu Pro Thr Asp Lys Thr Val Phe Ser Glu Asn Arg 
865                 870                 875                 880 


Asp Leu Arg Gln Val Gln Glu Leu Ser Lys Lys Thr Asp Ser Asp Ala 
                885                 890                 895     


Ile Val His Ser Ala Phe Asn Ser Asp Thr Asn Arg Ala Pro Gln Asn 
            900                 905                 910         


Ser Ser Pro Phe Ser Lys His His Thr Glu Ile Ser Val Ser Thr Asn 
        915                 920                 925             


Glu Gln Ala Ile Ala Val Glu Asn Ala Val Thr Thr Met Ala Ser Gln 
    930                 935                 940                 


Pro Ile Ser Thr Lys Ser Glu Asn Ile Cys Asn Ser Thr Arg Glu Ile 
945                 950                 955                 960 


Gln Gly Ile Glu Lys His Pro Tyr Pro Glu Ser Lys Pro Glu Glu Val 
                965                 970                 975     


Ser Arg Ser Ser Gly Ile Val Thr Ser Gly Ser Arg Lys Glu Arg Cys 
            980                 985                 990         


Ile Gly Gln Ile Phe Gln Thr Glu  Glu Tyr Ser Val Glu  Lys Ser Leu 
        995                 1000                 1005             


Gly Pro  Met Ile Leu Ile Asn  Lys Pro Leu Glu Asn  Met Glu Glu 
    1010                 1015                 1020             


Ala Arg  His Glu Asn Glu Gly  Leu Val Ser Ser Gly  Gln Ser Leu 
    1025                 1030                 1035             


Tyr Thr  Ser Gly Glu Lys Glu  Ser Asp Ser Ser Ala  Ser Thr Ser 
    1040                 1045                 1050             


Leu Pro  Val Glu Glu Ser Gln  Ala Gln Gly Asn Glu  Ser Leu Phe 
    1055                 1060                 1065             


Ser Lys  Tyr Thr Asn Ser Lys  Ile Pro Tyr Phe Leu  Leu Phe Leu 
    1070                 1075                 1080             


Ile Phe  Leu Ile Thr Val Tyr  His Tyr Asp Leu Met  Ile Gly Leu 
    1085                 1090                 1095             


Thr Phe  Tyr Val Leu Ser Leu  Ser Trp Leu Ser Trp  Glu Glu Gly 
    1100                 1105                 1110             


Arg Gln  Lys Glu Ser Val Lys  Lys Lys 
    1115                 1120         


<210>  2707
<211>  1019
<212>  PRT
<213>  Homo sapiens

<400>  2707

Met Gly Ser Lys Arg Gly Ile Ser Ser Arg His His Ser Leu Ser Ser 
1               5                   10                  15      


Tyr Glu Ile Met Phe Ala Ala Leu Phe Ala Ile Leu Val Val Leu Cys 
            20                  25                  30          


Ala Gly Leu Ile Ala Val Ser Cys Leu Thr Ile Lys Glu Ser Gln Arg 
        35                  40                  45              


Gly Ala Ala Leu Gly Gln Ser His Glu Ala Arg Ala Thr Phe Lys Ile 
    50                  55                  60                  


Thr Ser Gly Val Thr Tyr Asn Pro Asn Leu Gln Asp Lys Leu Ser Val 
65                  70                  75                  80  


Asp Phe Lys Val Leu Ala Phe Asp Leu Gln Gln Met Ile Asp Glu Ile 
                85                  90                  95      


Phe Leu Ser Ser Asn Leu Lys Asn Glu Tyr Lys Asn Ser Arg Val Leu 
            100                 105                 110         


Gln Phe Glu Asn Gly Ser Ile Ile Val Val Phe Asp Leu Phe Phe Ala 
        115                 120                 125             


Gln Trp Val Ser Asp Glu Asn Val Lys Glu Glu Leu Ile Gln Gly Leu 
    130                 135                 140                 


Glu Ala Asn Lys Ser Ser Gln Leu Val Thr Phe His Ile Asp Leu Asn 
145                 150                 155                 160 


Ser Val Asp Ile Leu Asp Lys Leu Thr Thr Thr Ser His Leu Ala Thr 
                165                 170                 175     


Pro Gly Asn Val Ser Ile Glu Cys Leu Pro Gly Ser Ser Pro Cys Thr 
            180                 185                 190         


Asp Ala Leu Thr Cys Ile Lys Ala Asp Leu Phe Cys Asp Gly Glu Val 
        195                 200                 205             


Asn Cys Pro Asp Gly Ser Asp Glu Asp Asn Lys Met Cys Ala Thr Val 
    210                 215                 220                 


Cys Asp Gly Arg Phe Leu Leu Thr Gly Ser Ser Gly Ser Phe Gln Ala 
225                 230                 235                 240 


Thr His Tyr Pro Lys Pro Ser Glu Thr Ser Val Val Cys Gln Trp Ile 
                245                 250                 255     


Ile Arg Val Asn Gln Gly Leu Ser Ile Lys Leu Ser Phe Asp Asp Phe 
            260                 265                 270         


Asn Thr Tyr Tyr Thr Asp Ile Leu Asp Ile Tyr Glu Gly Val Gly Ser 
        275                 280                 285             


Ser Lys Ile Leu Arg Ala Ser Ile Trp Glu Thr Asn Pro Gly Thr Ile 
    290                 295                 300                 


Arg Ile Phe Ser Asn Gln Val Thr Ala Thr Phe Leu Ile Glu Ser Asp 
305                 310                 315                 320 


Glu Ser Asp Tyr Val Gly Phe Asn Ala Thr Tyr Thr Ala Phe Asn Ser 
                325                 330                 335     


Ser Glu Leu Asn Asn Tyr Glu Lys Ile Asn Cys Asn Phe Glu Asp Gly 
            340                 345                 350         


Phe Cys Phe Trp Val Gln Asp Leu Asn Asp Asp Asn Glu Trp Glu Arg 
        355                 360                 365             


Ile Gln Gly Ser Thr Phe Ser Pro Phe Thr Gly Pro Asn Phe Asp His 
    370                 375                 380                 


Thr Phe Gly Asn Ala Ser Gly Phe Tyr Ile Ser Thr Pro Thr Gly Pro 
385                 390                 395                 400 


Gly Gly Arg Gln Glu Arg Val Gly Leu Leu Ser Leu Pro Leu Asp Pro 
                405                 410                 415     


Thr Leu Glu Pro Ala Cys Leu Ser Phe Trp Tyr His Met Tyr Gly Glu 
            420                 425                 430         


Asn Val His Lys Leu Ser Ile Asn Ile Ser Asn Asp Gln Asn Met Glu 
        435                 440                 445             


Lys Thr Val Phe Gln Lys Glu Gly Asn Tyr Gly Asp Asn Trp Asn Tyr 
    450                 455                 460                 


Gly Gln Val Thr Leu Asn Glu Thr Val Lys Phe Lys Val Ala Phe Asn 
465                 470                 475                 480 


Ala Phe Lys Asn Lys Ile Leu Ser Asp Ile Ala Leu Asp Asp Ile Ser 
                485                 490                 495     


Leu Thr Tyr Gly Ile Cys Asn Gly Ser Leu Tyr Pro Glu Pro Thr Leu 
            500                 505                 510         


Val Pro Thr Pro Pro Pro Glu Leu Pro Thr Asp Cys Gly Gly Pro Phe 
        515                 520                 525             


Glu Leu Trp Glu Pro Asn Thr Thr Phe Ser Ser Thr Asn Phe Pro Asn 
    530                 535                 540                 


Ser Tyr Pro Asn Leu Ala Phe Cys Val Trp Ile Leu Asn Ala Gln Lys 
545                 550                 555                 560 


Gly Lys Asn Ile Gln Leu His Phe Gln Glu Phe Asp Leu Glu Asn Ile 
                565                 570                 575     


Asn Asp Val Val Glu Ile Arg Asp Gly Glu Glu Ala Asp Ser Leu Leu 
            580                 585                 590         


Leu Ala Val Tyr Thr Gly Pro Gly Pro Val Lys Asp Val Phe Ser Thr 
        595                 600                 605             


Thr Asn Arg Met Thr Val Leu Leu Ile Thr Asn Asp Val Leu Ala Arg 
    610                 615                 620                 


Gly Gly Phe Lys Ala Asn Phe Thr Thr Gly Tyr His Leu Gly Ile Pro 
625                 630                 635                 640 


Glu Pro Cys Lys Ala Asp His Phe Gln Cys Lys Asn Gly Glu Cys Val 
                645                 650                 655     


Pro Leu Val Asn Leu Cys Asp Gly His Leu His Cys Glu Asp Gly Ser 
            660                 665                 670         


Asp Glu Ala Asp Cys Val Arg Phe Phe Asn Gly Thr Thr Asn Asn Asn 
        675                 680                 685             


Gly Leu Val Arg Phe Arg Ile Gln Ser Ile Trp His Thr Ala Cys Ala 
    690                 695                 700                 


Glu Asn Trp Thr Thr Gln Ile Ser Asn Asp Val Cys Gln Leu Leu Gly 
705                 710                 715                 720 


Leu Gly Ser Gly Asn Ser Ser Lys Pro Ile Phe Ser Thr Asp Gly Gly 
                725                 730                 735     


Pro Phe Val Lys Leu Asn Thr Ala Pro Asp Gly His Leu Ile Leu Thr 
            740                 745                 750         


Pro Ser Gln Gln Cys Leu Gln Asp Ser Leu Ile Arg Leu Gln Cys Asn 
        755                 760                 765             


His Lys Ser Cys Gly Lys Lys Leu Ala Ala Gln Asp Ile Thr Pro Lys 
    770                 775                 780                 


Ile Val Gly Gly Ser Asn Ala Lys Glu Gly Ala Trp Pro Trp Val Val 
785                 790                 795                 800 


Gly Leu Tyr Tyr Gly Gly Arg Leu Leu Cys Gly Ala Ser Leu Val Ser 
                805                 810                 815     


Ser Asp Trp Leu Val Ser Ala Ala His Cys Val Tyr Gly Arg Asn Leu 
            820                 825                 830         


Glu Pro Ser Lys Trp Thr Ala Ile Leu Gly Leu His Met Lys Ser Asn 
        835                 840                 845             


Leu Thr Ser Pro Gln Thr Val Pro Arg Leu Ile Asp Glu Ile Val Ile 
    850                 855                 860                 


Asn Pro His Tyr Asn Arg Arg Arg Lys Asp Asn Asp Ile Ala Met Met 
865                 870                 875                 880 


His Leu Glu Phe Lys Val Asn Tyr Thr Asp Tyr Ile Gln Pro Ile Cys 
                885                 890                 895     


Leu Pro Glu Glu Asn Gln Val Phe Pro Pro Gly Arg Asn Cys Ser Ile 
            900                 905                 910         


Ala Gly Trp Gly Thr Val Val Tyr Gln Gly Thr Thr Ala Asn Ile Leu 
        915                 920                 925             


Gln Glu Ala Asp Val Pro Leu Leu Ser Asn Glu Arg Cys Gln Gln Gln 
    930                 935                 940                 


Met Pro Glu Tyr Asn Ile Thr Glu Asn Met Ile Cys Ala Gly Tyr Glu 
945                 950                 955                 960 


Glu Gly Gly Ile Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Met 
                965                 970                 975     


Cys Gln Glu Asn Asn Arg Trp Phe Leu Ala Gly Val Thr Ser Phe Gly 
            980                 985                 990         


Tyr Lys Cys Ala Leu Pro Asn Arg  Pro Gly Val Tyr Ala  Arg Val Ser 
        995                 1000                 1005             


Arg Phe  Thr Glu Trp Ile Gln  Ser Phe Leu His 
    1010                 1015                 


<210>  2708
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  2708

Met Ala Ala Val Ser Val Tyr Ala Pro Pro Val Gly Gly Phe Ser Phe 
1               5                   10                  15      


Asp Asn Cys Arg Arg Asn Ala Val Leu Glu Ala Asp Phe Ala Lys Arg 
            20                  25                  30          


Gly Tyr Lys Leu Pro Lys Val Arg Lys Thr Gly Thr Thr Ile Ala Gly 
        35                  40                  45              


Val Val Tyr Lys Asp Gly Ile Val Leu Gly Ala Asp Thr Arg Ala Thr 
    50                  55                  60                  


Glu Gly Met Val Val Ala Asp Lys Asn Cys Ser Lys Ile His Phe Ile 
65                  70                  75                  80  


Ser Pro Asn Ile Tyr Cys Cys Gly Ala Gly Thr Ala Ala Asp Thr Asp 
                85                  90                  95      


Met Thr Thr Gln Leu Ile Ser Ser Asn Leu Glu Leu His Ser Leu Ser 
            100                 105                 110         


Thr Gly Arg Leu Pro Arg Val Val Thr Ala Asn Arg Met Leu Lys Gln 
        115                 120                 125             


Met Leu Phe Arg Tyr Gln Gly Tyr Ile Gly Ala Ala Leu Val Leu Gly 
    130                 135                 140                 


Gly Val Asp Val Thr Gly Pro His Leu Tyr Ser Ile Tyr Pro His Gly 
145                 150                 155                 160 


Ser Thr Asp Lys Leu Pro Tyr Val Thr Met Gly Ser Gly Ser Leu Ala 
                165                 170                 175     


Ala Met Ala Val Phe Glu Asp Lys Phe Arg Pro Asp Met Glu Glu Glu 
            180                 185                 190         


Glu Ala Lys Asn Leu Val Ser Glu Ala Ile Ala Ala Gly Ile Phe Asn 
        195                 200                 205             


Asp Leu Gly Ser Gly Ser Asn Ile Asp Leu Cys Val Ile Ser Lys Asn 
    210                 215                 220                 


Lys Leu Asp Phe Leu Arg Pro Tyr Thr Val Pro Asn Lys Lys Gly Thr 
225                 230                 235                 240 


Arg Leu Gly Arg Tyr Arg Cys Glu Lys Gly Thr Thr Ala Val Leu Thr 
                245                 250                 255     


Glu Lys Ile Thr Pro Leu Glu Ile Glu Val Leu Glu Glu Thr Val Gln 
            260                 265                 270         


Thr Met Asp Thr Ser 
        275         


<210>  2709
<211>  1070
<212>  PRT
<213>  Homo sapiens

<400>  2709

Met Gly Ala Ala Arg Gly Ser Pro Ala Arg Pro Arg Arg Leu Pro Leu 
1               5                   10                  15      


Leu Ser Val Leu Leu Leu Pro Leu Leu Gly Gly Thr Gln Thr Ala Ile 
            20                  25                  30          


Val Phe Ile Lys Gln Pro Ser Ser Gln Asp Ala Leu Gln Gly Arg Arg 
        35                  40                  45              


Ala Leu Leu Arg Cys Glu Val Glu Ala Pro Gly Pro Val His Val Tyr 
    50                  55                  60                  


Trp Leu Leu Asp Gly Ala Pro Val Gln Asp Thr Glu Arg Arg Phe Ala 
65                  70                  75                  80  


Gln Gly Ser Ser Leu Ser Phe Ala Ala Val Asp Arg Leu Gln Asp Ser 
                85                  90                  95      


Gly Thr Phe Gln Cys Val Ala Arg Asp Asp Val Thr Gly Glu Glu Ala 
            100                 105                 110         


Arg Ser Ala Asn Ala Ser Phe Asn Ile Lys Trp Ile Glu Ala Gly Pro 
        115                 120                 125             


Val Val Leu Lys His Pro Ala Ser Glu Ala Glu Ile Gln Pro Gln Thr 
    130                 135                 140                 


Gln Val Thr Leu Arg Cys His Ile Asp Gly His Pro Arg Pro Thr Tyr 
145                 150                 155                 160 


Gln Trp Phe Arg Asp Gly Thr Pro Leu Ser Asp Gly Gln Ser Asn His 
                165                 170                 175     


Thr Val Ser Ser Lys Glu Arg Asn Leu Thr Leu Arg Pro Ala Gly Pro 
            180                 185                 190         


Glu His Ser Gly Leu Tyr Ser Cys Cys Ala His Ser Ala Phe Gly Gln 
        195                 200                 205             


Ala Cys Ser Ser Gln Asn Phe Thr Leu Ser Ile Ala Asp Glu Ser Phe 
    210                 215                 220                 


Ala Arg Val Val Leu Ala Pro Gln Asp Val Val Val Ala Arg Tyr Glu 
225                 230                 235                 240 


Glu Ala Met Phe His Cys Gln Phe Ser Ala Gln Pro Pro Pro Ser Leu 
                245                 250                 255     


Gln Trp Leu Phe Glu Asp Glu Thr Pro Ile Thr Asn Arg Ser Arg Pro 
            260                 265                 270         


Pro His Leu Arg Arg Ala Thr Val Phe Ala Asn Gly Ser Leu Leu Leu 
        275                 280                 285             


Thr Gln Val Arg Pro Arg Asn Ala Gly Ile Tyr Arg Cys Ile Gly Gln 
    290                 295                 300                 


Gly Gln Arg Gly Pro Pro Ile Ile Leu Glu Ala Thr Leu His Leu Ala 
305                 310                 315                 320 


Glu Ile Glu Asp Met Pro Leu Phe Glu Pro Arg Val Phe Thr Ala Gly 
                325                 330                 335     


Ser Glu Glu Arg Val Thr Cys Leu Pro Pro Lys Gly Leu Pro Glu Pro 
            340                 345                 350         


Ser Val Trp Trp Glu His Ala Gly Val Arg Leu Pro Thr His Gly Arg 
        355                 360                 365             


Val Tyr Gln Lys Gly His Glu Leu Val Leu Ala Asn Ile Ala Glu Ser 
    370                 375                 380                 


Asp Ala Gly Val Tyr Thr Cys His Ala Ala Asn Leu Ala Gly Gln Arg 
385                 390                 395                 400 


Arg Gln Asp Val Asn Ile Thr Val Ala Thr Val Pro Ser Trp Leu Lys 
                405                 410                 415     


Lys Pro Gln Asp Ser Gln Leu Glu Glu Gly Lys Pro Gly Tyr Leu Asp 
            420                 425                 430         


Cys Leu Thr Gln Ala Thr Pro Lys Pro Thr Val Val Trp Tyr Arg Asn 
        435                 440                 445             


Gln Met Leu Ile Ser Glu Asp Ser Arg Phe Glu Val Phe Lys Asn Gly 
    450                 455                 460                 


Thr Leu Arg Ile Asn Ser Val Glu Val Tyr Asp Gly Thr Trp Tyr Arg 
465                 470                 475                 480 


Cys Met Ser Ser Thr Pro Ala Gly Ser Ile Glu Ala Gln Ala Arg Val 
                485                 490                 495     


Gln Val Leu Glu Lys Leu Lys Phe Thr Pro Pro Pro Gln Pro Gln Gln 
            500                 505                 510         


Cys Met Glu Phe Asp Lys Glu Ala Thr Val Pro Cys Ser Ala Thr Gly 
        515                 520                 525             


Arg Glu Lys Pro Thr Ile Lys Trp Glu Arg Ala Asp Gly Ser Ser Leu 
    530                 535                 540                 


Pro Glu Trp Val Thr Asp Asn Ala Gly Thr Leu His Phe Ala Arg Val 
545                 550                 555                 560 


Thr Arg Asp Asp Ala Gly Asn Tyr Thr Cys Ile Ala Ser Asn Gly Pro 
                565                 570                 575     


Gln Gly Gln Ile Arg Ala His Val Gln Leu Thr Val Ala Val Phe Ile 
            580                 585                 590         


Thr Phe Lys Val Glu Pro Glu Arg Thr Thr Val Tyr Gln Gly His Thr 
        595                 600                 605             


Ala Leu Leu Gln Cys Glu Ala Gln Gly Asp Pro Lys Pro Leu Ile Gln 
    610                 615                 620                 


Trp Lys Gly Lys Asp Arg Ile Leu Asp Pro Thr Lys Leu Gly Pro Arg 
625                 630                 635                 640 


Met His Ile Phe Gln Asn Gly Ser Leu Val Ile His Asp Val Ala Pro 
                645                 650                 655     


Glu Asp Ser Gly Arg Tyr Thr Cys Ile Ala Gly Asn Ser Cys Asn Ile 
            660                 665                 670         


Lys His Thr Glu Ala Pro Leu Tyr Val Val Asp Lys Pro Val Pro Glu 
        675                 680                 685             


Glu Ser Glu Gly Pro Gly Ser Pro Pro Pro Tyr Lys Met Ile Gln Thr 
    690                 695                 700                 


Ile Gly Leu Ser Val Gly Ala Ala Val Ala Tyr Ile Ile Ala Val Leu 
705                 710                 715                 720 


Gly Leu Met Phe Tyr Cys Lys Lys Arg Cys Lys Ala Lys Arg Leu Gln 
                725                 730                 735     


Lys Gln Pro Glu Gly Glu Glu Pro Glu Met Glu Cys Leu Asn Gly Gly 
            740                 745                 750         


Pro Leu Gln Asn Gly Gln Pro Ser Ala Glu Ile Gln Glu Glu Val Ala 
        755                 760                 765             


Leu Thr Ser Leu Gly Ser Gly Pro Ala Ala Thr Asn Lys Arg His Ser 
    770                 775                 780                 


Thr Ser Asp Lys Met His Phe Pro Arg Ser Ser Leu Gln Pro Ile Thr 
785                 790                 795                 800 


Thr Leu Gly Lys Ser Glu Phe Gly Glu Val Phe Leu Ala Lys Ala Gln 
                805                 810                 815     


Gly Leu Glu Glu Gly Val Ala Glu Thr Leu Val Leu Val Lys Ser Leu 
            820                 825                 830         


Gln Ser Lys Asp Glu Gln Gln Gln Leu Asp Phe Arg Arg Glu Leu Glu 
        835                 840                 845             


Met Phe Gly Lys Leu Asn His Ala Asn Val Val Arg Leu Leu Gly Leu 
    850                 855                 860                 


Cys Arg Glu Ala Glu Pro His Tyr Met Val Leu Glu Tyr Val Asp Leu 
865                 870                 875                 880 


Gly Asp Leu Lys Gln Phe Leu Arg Ile Ser Lys Ser Lys Asp Glu Lys 
                885                 890                 895     


Leu Lys Ser Gln Pro Leu Ser Thr Lys Gln Lys Val Ala Leu Cys Thr 
            900                 905                 910         


Gln Val Ala Leu Gly Met Glu His Leu Ser Asn Asn Arg Phe Val His 
        915                 920                 925             


Lys Asp Leu Ala Ala Arg Asn Cys Leu Val Ser Ala Gln Arg Gln Val 
    930                 935                 940                 


Lys Val Ser Ala Leu Gly Leu Ser Lys Asp Val Tyr Asn Ser Glu Tyr 
945                 950                 955                 960 


Tyr His Phe Arg Gln Ala Trp Val Pro Leu Arg Trp Met Ser Pro Glu 
                965                 970                 975     


Ala Ile Leu Glu Gly Asp Phe Ser Thr Lys Ser Asp Val Trp Ala Phe 
            980                 985                 990         


Gly Val Leu Met Trp Glu Val Phe  Thr His Gly Glu Met  Pro His Gly 
        995                 1000                 1005             


Gly Gln  Ala Asp Asp Glu Val  Leu Ala Asp Leu Gln  Ala Gly Lys 
    1010                 1015                 1020             


Ala Arg  Leu Pro Gln Pro Glu  Gly Cys Pro Ser Lys  Leu Tyr Arg 
    1025                 1030                 1035             


Leu Met  Gln Arg Cys Trp Ala  Leu Ser Pro Lys Asp  Arg Pro Ser 
    1040                 1045                 1050             


Phe Ser  Glu Ile Ala Ser Ala  Leu Gly Asp Ser Thr  Val Asp Ser 
    1055                 1060                 1065             


Lys Pro  
    1070 


<210>  2710
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  2710

Met Gln Ala Gln Gln Tyr Gln Gln Gln Arg Arg Lys Phe Ala Ala Ala 
1               5                   10                  15      


Phe Leu Ala Phe Ile Phe Ile Leu Ala Ala Val Asp Thr Ala Glu Ala 
            20                  25                  30          


Gly Lys Lys Glu Lys Pro Glu Lys Lys Val Lys Lys Ser Asp Cys Gly 
        35                  40                  45              


Glu Trp Gln Trp Ser Val Cys Val Pro Thr Ser Gly Asp Cys Gly Leu 
    50                  55                  60                  


Gly Thr Arg Glu Gly Thr Arg Thr Gly Ala Glu Cys Lys Gln Thr Met 
65                  70                  75                  80  


Lys Thr Gln Arg Cys Lys Ile Pro Cys Asn Trp Lys Lys Gln Phe Gly 
                85                  90                  95      


Ala Glu Cys Lys Tyr Gln Phe Gln Ala Trp Gly Glu Cys Asp Leu Asn 
            100                 105                 110         


Thr Ala Leu Lys Thr Arg Thr Gly Ser Leu Lys Arg Ala Leu His Asn 
        115                 120                 125             


Ala Glu Cys Gln Lys Thr Val Thr Ile Ser Lys Pro Cys Gly Lys Leu 
    130                 135                 140                 


Thr Lys Pro Lys Pro Gln Ala Glu Ser Lys Lys Lys Lys Lys Glu Gly 
145                 150                 155                 160 


Lys Lys Gln Glu Lys Met Leu Asp 
                165             


<210>  2711
<211>  747
<212>  PRT
<213>  Homo sapiens

<400>  2711

Met Arg Arg Cys Asn Ser Gly Ser Gly Pro Pro Pro Ser Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Trp Leu Leu Ala Val Pro Gly Ala Asn Ala Ala Pro Arg 
            20                  25                  30          


Ser Ala Leu Tyr Ser Pro Ser Asp Pro Leu Thr Leu Leu Gln Ala Asp 
        35                  40                  45              


Thr Val Arg Gly Ala Val Leu Gly Ser Arg Ser Ala Trp Ala Val Glu 
    50                  55                  60                  


Phe Phe Ala Ser Trp Cys Gly His Cys Ile Ala Phe Ala Pro Thr Trp 
65                  70                  75                  80  


Lys Ala Leu Ala Glu Asp Val Lys Ala Trp Arg Pro Ala Leu Tyr Leu 
                85                  90                  95      


Ala Ala Leu Asp Cys Ala Glu Glu Thr Asn Ser Ala Val Cys Arg Asp 
            100                 105                 110         


Phe Asn Ile Pro Gly Phe Pro Thr Val Arg Phe Phe Lys Ala Phe Thr 
        115                 120                 125             


Lys Asn Gly Ser Gly Ala Val Phe Pro Val Ala Gly Ala Asp Val Gln 
    130                 135                 140                 


Thr Leu Arg Glu Arg Leu Ile Asp Ala Leu Glu Ser His His Asp Thr 
145                 150                 155                 160 


Trp Pro Pro Ala Cys Pro Pro Leu Glu Pro Ala Lys Leu Glu Glu Ile 
                165                 170                 175     


Asp Gly Phe Phe Ala Arg Asn Asn Glu Glu Tyr Leu Ala Leu Ile Phe 
            180                 185                 190         


Glu Lys Gly Gly Ser Tyr Leu Gly Arg Glu Val Ala Leu Asp Leu Ser 
        195                 200                 205             


Gln His Lys Gly Val Ala Val Arg Arg Val Leu Asn Thr Glu Ala Asn 
    210                 215                 220                 


Val Val Arg Lys Phe Gly Val Thr Asp Phe Pro Ser Cys Tyr Leu Leu 
225                 230                 235                 240 


Phe Arg Asn Gly Ser Val Ser Arg Val Pro Val Leu Met Glu Ser Arg 
                245                 250                 255     


Ser Phe Tyr Thr Ala Tyr Leu Gln Arg Leu Ser Gly Leu Thr Arg Glu 
            260                 265                 270         


Ala Ala Gln Thr Thr Val Ala Pro Thr Thr Ala Asn Lys Ile Ala Pro 
        275                 280                 285             


Thr Val Trp Lys Leu Ala Asp Arg Ser Lys Ile Tyr Met Ala Asp Leu 
    290                 295                 300                 


Glu Ser Ala Leu His Tyr Ile Leu Arg Ile Glu Val Gly Arg Phe Pro 
305                 310                 315                 320 


Val Leu Glu Gly Gln Arg Leu Val Ala Leu Lys Lys Phe Val Ala Val 
                325                 330                 335     


Leu Ala Lys Tyr Phe Pro Gly Arg Pro Leu Val Gln Asn Phe Leu His 
            340                 345                 350         


Ser Val Asn Glu Trp Leu Lys Arg Gln Lys Arg Asn Lys Ile Pro Tyr 
        355                 360                 365             


Ser Phe Phe Lys Thr Ala Leu Asp Asp Arg Lys Glu Gly Ala Val Leu 
    370                 375                 380                 


Ala Lys Lys Val Asn Trp Ile Gly Cys Gln Gly Ser Glu Pro His Phe 
385                 390                 395                 400 


Arg Gly Phe Pro Cys Ser Leu Trp Val Leu Phe His Phe Leu Thr Val 
                405                 410                 415     


Gln Ala Ala Arg Gln Asn Val Asp His Ser Gln Glu Ala Ala Lys Ala 
            420                 425                 430         


Lys Glu Val Leu Pro Ala Ile Arg Gly Tyr Val His Tyr Phe Phe Gly 
        435                 440                 445             


Cys Arg Asp Cys Ala Ser His Phe Glu Gln Met Ala Ala Ala Ser Met 
    450                 455                 460                 


His Arg Val Gly Ser Pro Asn Ala Ala Val Leu Trp Leu Trp Ser Ser 
465                 470                 475                 480 


His Asn Arg Val Asn Ala Arg Leu Ala Gly Ala Pro Ser Glu Asp Pro 
                485                 490                 495     


Gln Phe Pro Lys Val Gln Trp Pro Pro Arg Glu Leu Cys Ser Ala Cys 
            500                 505                 510         


His Asn Glu Arg Leu Asp Val Pro Val Trp Asp Val Glu Ala Thr Leu 
        515                 520                 525             


Asn Phe Leu Lys Ala His Phe Ser Pro Ser Asn Ile Ile Leu Asp Phe 
    530                 535                 540                 


Pro Ala Ala Gly Ser Ala Ala Arg Arg Asp Val Gln Asn Val Ala Ala 
545                 550                 555                 560 


Ala Pro Glu Leu Ala Met Gly Ala Leu Glu Leu Glu Ser Arg Asn Ser 
                565                 570                 575     


Thr Leu Asp Pro Gly Lys Pro Glu Met Met Lys Ser Pro Thr Asn Thr 
            580                 585                 590         


Thr Pro His Val Pro Ala Glu Gly Pro Glu Ala Ser Arg Pro Pro Lys 
        595                 600                 605             


Leu His Pro Gly Leu Arg Ala Ala Pro Gly Gln Glu Pro Pro Glu His 
    610                 615                 620                 


Met Ala Glu Leu Gln Arg Asn Glu Gln Glu Gln Pro Leu Gly Gln Trp 
625                 630                 635                 640 


His Leu Ser Lys Arg Asp Thr Gly Ala Ala Leu Leu Ala Glu Ser Arg 
                645                 650                 655     


Ala Glu Lys Asn Arg Leu Trp Gly Pro Leu Glu Val Arg Arg Val Gly 
            660                 665                 670         


Arg Ser Ser Lys Gln Leu Val Asp Ile Pro Glu Gly Gln Leu Glu Ala 
        675                 680                 685             


Arg Ala Gly Arg Gly Arg Gly Gln Trp Leu Gln Val Leu Gly Gly Gly 
    690                 695                 700                 


Phe Ser Tyr Leu Asp Ile Ser Leu Cys Val Gly Leu Tyr Ser Leu Ser 
705                 710                 715                 720 


Phe Met Gly Leu Leu Ala Met Tyr Thr Tyr Phe Gln Ala Lys Ile Arg 
                725                 730                 735     


Ala Leu Lys Gly His Ala Gly His Pro Ala Ala 
            740                 745         


<210>  2712
<211>  435
<212>  PRT
<213>  Homo sapiens

<400>  2712

Met Glu Met Glu Lys Glu Phe Glu Gln Ile Asp Lys Ser Gly Ser Trp 
1               5                   10                  15      


Ala Ala Ile Tyr Gln Asp Ile Arg His Glu Ala Ser Asp Phe Pro Cys 
            20                  25                  30          


Arg Val Ala Lys Leu Pro Lys Asn Lys Asn Arg Asn Arg Tyr Arg Asp 
        35                  40                  45              


Val Ser Pro Phe Asp His Ser Arg Ile Lys Leu His Gln Glu Asp Asn 
    50                  55                  60                  


Asp Tyr Ile Asn Ala Ser Leu Ile Lys Met Glu Glu Ala Gln Arg Ser 
65                  70                  75                  80  


Tyr Ile Leu Thr Gln Gly Pro Leu Pro Asn Thr Cys Gly His Phe Trp 
                85                  90                  95      


Glu Met Val Trp Glu Gln Lys Ser Arg Gly Val Val Met Leu Asn Arg 
            100                 105                 110         


Val Met Glu Lys Gly Ser Leu Lys Cys Ala Gln Tyr Trp Pro Gln Lys 
        115                 120                 125             


Glu Glu Lys Glu Met Ile Phe Glu Asp Thr Asn Leu Lys Leu Thr Leu 
    130                 135                 140                 


Ile Ser Glu Asp Ile Lys Ser Tyr Tyr Thr Val Arg Gln Leu Glu Leu 
145                 150                 155                 160 


Glu Asn Leu Thr Thr Gln Glu Thr Arg Glu Ile Leu His Phe His Tyr 
                165                 170                 175     


Thr Thr Trp Pro Asp Phe Gly Val Pro Glu Ser Pro Ala Ser Phe Leu 
            180                 185                 190         


Asn Phe Leu Phe Lys Val Arg Glu Ser Gly Ser Leu Ser Pro Glu His 
        195                 200                 205             


Gly Pro Val Val Val His Cys Ser Ala Gly Ile Gly Arg Ser Gly Thr 
    210                 215                 220                 


Phe Cys Leu Ala Asp Thr Cys Leu Leu Leu Met Asp Lys Arg Lys Asp 
225                 230                 235                 240 


Pro Ser Ser Val Asp Ile Lys Lys Val Leu Leu Glu Met Arg Lys Phe 
                245                 250                 255     


Arg Met Gly Leu Ile Gln Thr Ala Asp Gln Leu Arg Phe Ser Tyr Leu 
            260                 265                 270         


Ala Val Ile Glu Gly Ala Lys Phe Ile Met Gly Asp Ser Ser Val Gln 
        275                 280                 285             


Asp Gln Trp Lys Glu Leu Ser His Glu Asp Leu Glu Pro Pro Pro Glu 
    290                 295                 300                 


His Ile Pro Pro Pro Pro Arg Pro Pro Lys Arg Ile Leu Glu Pro His 
305                 310                 315                 320 


Asn Gly Lys Cys Arg Glu Phe Phe Pro Asn His Gln Trp Val Lys Glu 
                325                 330                 335     


Glu Thr Gln Glu Asp Lys Asp Cys Pro Ile Lys Glu Glu Lys Gly Ser 
            340                 345                 350         


Pro Leu Asn Ala Ala Pro Tyr Gly Ile Glu Ser Met Ser Gln Asp Thr 
        355                 360                 365             


Glu Val Arg Ser Arg Val Val Gly Gly Ser Leu Arg Gly Ala Gln Ala 
    370                 375                 380                 


Ala Ser Pro Ala Lys Gly Glu Pro Ser Leu Pro Glu Lys Asp Glu Asp 
385                 390                 395                 400 


His Ala Leu Ser Tyr Trp Lys Pro Phe Leu Val Asn Met Cys Val Ala 
                405                 410                 415     


Thr Val Leu Thr Ala Gly Ala Tyr Leu Cys Tyr Arg Phe Leu Phe Asn 
            420                 425                 430         


Ser Asn Thr 
        435 


<210>  2713
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  2713

Met Pro Thr Thr Ile Glu Arg Glu Phe Glu Glu Leu Asp Thr Gln Arg 
1               5                   10                  15      


Arg Trp Gln Pro Leu Tyr Leu Glu Ile Arg Asn Glu Ser His Asp Tyr 
            20                  25                  30          


Pro His Arg Val Ala Lys Phe Pro Glu Asn Arg Asn Arg Asn Arg Tyr 
        35                  40                  45              


Arg Asp Val Ser Pro Tyr Asp His Ser Arg Val Lys Leu Gln Asn Ala 
    50                  55                  60                  


Glu Asn Asp Tyr Ile Asn Ala Ser Leu Val Asp Ile Glu Glu Ala Gln 
65                  70                  75                  80  


Arg Ser Tyr Ile Leu Thr Gln Gly Pro Leu Pro Asn Thr Cys Cys His 
                85                  90                  95      


Phe Trp Leu Met Val Trp Gln Gln Lys Thr Lys Ala Val Val Met Leu 
            100                 105                 110         


Asn Arg Ile Val Glu Lys Glu Ser Val Lys Cys Ala Gln Tyr Trp Pro 
        115                 120                 125             


Thr Asp Asp Gln Glu Met Leu Phe Lys Glu Thr Gly Phe Ser Val Lys 
    130                 135                 140                 


Leu Leu Ser Glu Asp Val Lys Ser Tyr Tyr Thr Val His Leu Leu Gln 
145                 150                 155                 160 


Leu Glu Asn Ile Asn Ser Gly Glu Thr Arg Thr Ile Ser His Phe His 
                165                 170                 175     


Tyr Thr Thr Trp Pro Asp Phe Gly Val Pro Glu Ser Pro Ala Ser Phe 
            180                 185                 190         


Leu Asn Phe Leu Phe Lys Val Arg Glu Ser Gly Ser Leu Asn Pro Asp 
        195                 200                 205             


His Gly Pro Ala Val Ile His Cys Ser Ala Gly Ile Gly Arg Ser Gly 
    210                 215                 220                 


Thr Phe Ser Leu Val Asp Thr Cys Leu Val Leu Met Glu Lys Gly Asp 
225                 230                 235                 240 


Asp Ile Asn Ile Lys Gln Val Leu Leu Asn Met Arg Lys Tyr Arg Met 
                245                 250                 255     


Gly Leu Ile Gln Thr Pro Asp Gln Leu Arg Phe Ser Tyr Met Ala Ile 
            260                 265                 270         


Ile Glu Gly Ala Lys Cys Ile Lys Gly Asp Ser Ser Ile Gln Lys Arg 
        275                 280                 285             


Trp Lys Glu Leu Ser Lys Glu Asp Leu Ser Pro Ala Phe Asp His Ser 
    290                 295                 300                 


Pro Asn Lys Ile Met Thr Glu Lys Tyr Asn Gly Asn Arg Ile Gly Leu 
305                 310                 315                 320 


Glu Glu Glu Lys Leu Thr Gly Asp Arg Cys Thr Gly Leu Ser Ser Lys 
                325                 330                 335     


Met Gln Asp Thr Met Glu Glu Asn Ser Glu Ser Ala Leu Arg Lys Arg 
            340                 345                 350         


Ile Arg Glu Asp Arg Lys Ala Thr Thr Ala Gln Lys Val Gln Gln Met 
        355                 360                 365             


Lys Gln Arg Leu Asn Glu Asn Glu Arg Lys Arg Lys Arg Trp Leu Tyr 
    370                 375                 380                 


Trp Gln Pro Ile Leu Thr Lys Met Gly Phe Met Ser Val Ile Leu Val 
385                 390                 395                 400 


Gly Ala Phe Val Gly Trp Thr Leu Phe Phe Gln Gln Asn Ala Leu 
                405                 410                 415 


<210>  2714
<211>  802
<212>  PRT
<213>  Homo sapiens

<400>  2714

Met Asp Ser Trp Phe Ile Leu Val Leu Leu Gly Ser Gly Leu Ile Cys 
1               5                   10                  15      


Val Ser Ala Asn Asn Ala Thr Thr Val Ala Pro Ser Val Gly Ile Thr 
            20                  25                  30          


Arg Leu Ile Asn Ser Ser Thr Ala Glu Pro Val Lys Glu Glu Ala Lys 
        35                  40                  45              


Thr Ser Asn Pro Thr Ser Ser Leu Thr Ser Leu Ser Val Ala Pro Thr 
    50                  55                  60                  


Phe Ser Pro Asn Ile Thr Leu Gly Pro Thr Tyr Leu Thr Thr Val Asn 
65                  70                  75                  80  


Ser Ser Asp Ser Asp Asn Gly Thr Thr Arg Thr Ala Ser Thr Asn Ser 
                85                  90                  95      


Ile Gly Ile Thr Ile Ser Pro Asn Gly Thr Trp Leu Pro Asp Asn Gln 
            100                 105                 110         


Phe Thr Asp Ala Arg Thr Glu Pro Trp Glu Gly Asn Ser Ser Thr Ala 
        115                 120                 125             


Ala Thr Thr Pro Glu Thr Phe Pro Pro Ser Gly Asn Ser Asp Ser Lys 
    130                 135                 140                 


Asp Arg Arg Asp Glu Thr Pro Ile Ile Ala Val Met Val Ala Leu Ser 
145                 150                 155                 160 


Ser Leu Leu Val Ile Val Phe Ile Ile Ile Val Leu Tyr Met Leu Arg 
                165                 170                 175     


Phe Lys Lys Tyr Lys Gln Ala Gly Ser His Ser Asn Ser Phe Arg Leu 
            180                 185                 190         


Ser Asn Gly Arg Thr Glu Asp Val Glu Pro Gln Ser Val Pro Leu Leu 
        195                 200                 205             


Ala Arg Ser Pro Ser Thr Asn Arg Lys Tyr Pro Pro Leu Pro Val Asp 
    210                 215                 220                 


Lys Leu Glu Glu Glu Ile Asn Arg Arg Met Ala Asp Asp Asn Lys Leu 
225                 230                 235                 240 


Phe Arg Glu Glu Phe Asn Ala Leu Pro Ala Cys Pro Ile Gln Ala Thr 
                245                 250                 255     


Cys Glu Ala Ala Ser Lys Glu Glu Asn Lys Glu Lys Asn Arg Tyr Val 
            260                 265                 270         


Asn Ile Leu Pro Tyr Asp His Ser Arg Val His Leu Thr Pro Val Glu 
        275                 280                 285             


Gly Val Pro Asp Ser Asp Tyr Ile Asn Ala Ser Phe Ile Asn Gly Tyr 
    290                 295                 300                 


Gln Glu Lys Asn Lys Phe Ile Ala Ala Gln Gly Pro Lys Glu Glu Thr 
305                 310                 315                 320 


Val Asn Asp Phe Trp Arg Met Ile Trp Glu Gln Asn Thr Ala Thr Ile 
                325                 330                 335     


Val Met Val Thr Asn Leu Lys Glu Arg Lys Glu Cys Lys Cys Ala Gln 
            340                 345                 350         


Tyr Trp Pro Asp Gln Gly Cys Trp Thr Tyr Gly Asn Ile Arg Val Ser 
        355                 360                 365             


Val Glu Asp Val Thr Val Leu Val Asp Tyr Thr Val Arg Lys Phe Cys 
    370                 375                 380                 


Ile Gln Gln Val Gly Asp Met Thr Asn Arg Lys Pro Gln Arg Leu Ile 
385                 390                 395                 400 


Thr Gln Phe His Phe Thr Ser Trp Pro Asp Phe Gly Val Pro Phe Thr 
                405                 410                 415     


Pro Ile Gly Met Leu Lys Phe Leu Lys Lys Val Lys Ala Cys Asn Pro 
            420                 425                 430         


Gln Tyr Ala Gly Ala Ile Val Val His Cys Ser Ala Gly Val Gly Arg 
        435                 440                 445             


Thr Gly Thr Phe Val Val Ile Asp Ala Met Leu Asp Met Met His Thr 
    450                 455                 460                 


Glu Arg Lys Val Asp Val Tyr Gly Phe Val Ser Arg Ile Arg Ala Gln 
465                 470                 475                 480 


Arg Cys Gln Met Val Gln Thr Asp Met Gln Tyr Val Phe Ile Tyr Gln 
                485                 490                 495     


Ala Leu Leu Glu His Tyr Leu Tyr Gly Asp Thr Glu Leu Glu Val Thr 
            500                 505                 510         


Ser Leu Glu Thr His Leu Gln Lys Ile Tyr Asn Lys Ile Pro Gly Thr 
        515                 520                 525             


Ser Asn Asn Gly Leu Glu Glu Glu Phe Lys Lys Leu Thr Ser Ile Lys 
    530                 535                 540                 


Ile Gln Asn Asp Lys Met Arg Thr Gly Asn Leu Pro Ala Asn Met Lys 
545                 550                 555                 560 


Lys Asn Arg Val Leu Gln Ile Ile Pro Tyr Glu Phe Asn Arg Val Ile 
                565                 570                 575     


Ile Pro Val Lys Arg Gly Glu Glu Asn Thr Asp Tyr Val Asn Ala Ser 
            580                 585                 590         


Phe Ile Asp Gly Tyr Arg Gln Lys Asp Ser Tyr Ile Ala Ser Gln Gly 
        595                 600                 605             


Pro Leu Leu His Thr Ile Glu Asp Phe Trp Arg Met Ile Trp Glu Trp 
    610                 615                 620                 


Lys Ser Cys Ser Ile Val Met Leu Thr Glu Leu Glu Glu Arg Gly Gln 
625                 630                 635                 640 


Glu Lys Cys Ala Gln Tyr Trp Pro Ser Asp Gly Leu Val Ser Tyr Gly 
                645                 650                 655     


Asp Ile Thr Val Glu Leu Lys Lys Glu Glu Glu Cys Glu Ser Tyr Thr 
            660                 665                 670         


Val Arg Asp Leu Leu Val Thr Asn Thr Arg Glu Asn Lys Ser Arg Gln 
        675                 680                 685             


Ile Arg Gln Phe His Phe His Gly Trp Pro Glu Val Gly Ile Pro Ser 
    690                 695                 700                 


Asp Gly Lys Gly Met Ile Ser Ile Ile Ala Ala Val Gln Lys Gln Gln 
705                 710                 715                 720 


Gln Gln Ser Gly Asn His Pro Ile Thr Val His Cys Ser Ala Gly Ala 
                725                 730                 735     


Gly Arg Thr Gly Thr Phe Cys Ala Leu Ser Thr Val Leu Glu Arg Val 
            740                 745                 750         


Lys Ala Glu Gly Ile Leu Asp Val Phe Gln Thr Val Lys Ser Leu Arg 
        755                 760                 765             


Leu Gln Arg Pro His Met Val Gln Thr Leu Glu Gln Tyr Glu Phe Cys 
    770                 775                 780                 


Tyr Lys Val Val Gln Glu Tyr Ile Asp Ala Phe Ser Asp Tyr Ala Asn 
785                 790                 795                 800 


Phe Lys 
        


<210>  2715
<211>  1306
<212>  PRT
<213>  Homo sapiens

<400>  2715

Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 
1               5                   10                  15      


Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 
            20                  25                  30          


Thr Gly Leu Thr Thr Ala Lys Met Pro Ser Val Pro Leu Ser Ser Asp 
        35                  40                  45              


Pro Leu Pro Thr His Thr Thr Ala Phe Ser Pro Ala Ser Thr Phe Glu 
    50                  55                  60                  


Arg Glu Asn Asp Phe Ser Glu Thr Thr Thr Ser Leu Ser Pro Asp Asn 
65                  70                  75                  80  


Thr Ser Thr Gln Val Ser Pro Asp Ser Leu Asp Asn Ala Ser Ala Phe 
                85                  90                  95      


Asn Thr Thr Gly Val Ser Ser Val Gln Thr Pro His Leu Pro Thr His 
            100                 105                 110         


Ala Asp Ser Gln Thr Pro Ser Ala Gly Thr Asp Thr Gln Thr Phe Ser 
        115                 120                 125             


Gly Ser Ala Ala Asn Ala Lys Leu Asn Pro Thr Pro Gly Ser Asn Ala 
    130                 135                 140                 


Ile Ser Asp Val Pro Gly Glu Arg Ser Thr Ala Ser Thr Phe Pro Thr 
145                 150                 155                 160 


Asp Pro Val Ser Pro Leu Thr Thr Thr Leu Ser Leu Ala His His Ser 
                165                 170                 175     


Ser Ala Ala Leu Pro Ala Arg Thr Ser Asn Thr Thr Ile Thr Ala Asn 
            180                 185                 190         


Thr Ser Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro 
        195                 200                 205             


Ser Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser 
    210                 215                 220                 


Lys Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu 
225                 230                 235                 240 


Tyr Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu 
                245                 250                 255     


Asn Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn 
            260                 265                 270         


Leu Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys 
        275                 280                 285             


Thr Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu 
    290                 295                 300                 


Lys Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr 
305                 310                 315                 320 


Ile Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln 
                325                 330                 335     


Asn Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys 
            340                 345                 350         


Glu Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp 
        355                 360                 365             


Ser Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile 
    370                 375                 380                 


Ile Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys 
385                 390                 395                 400 


Arg Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln 
                405                 410                 415     


Arg Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys 
            420                 425                 430         


Asp Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn 
        435                 440                 445             


Leu Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile 
    450                 455                 460                 


Ala Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr 
465                 470                 475                 480 


Lys Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr 
                485                 490                 495     


Ser Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn 
            500                 505                 510         


Gly Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu 
        515                 520                 525             


Val Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu 
    530                 535                 540                 


Gln Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp 
545                 550                 555                 560 


Tyr Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser 
                565                 570                 575     


Lys Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile 
            580                 585                 590         


Ala Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg 
        595                 600                 605             


Ser Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu 
    610                 615                 620                 


Lys Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu 
625                 630                 635                 640 


Thr Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu 
                645                 650                 655     


Phe Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala 
            660                 665                 670         


Arg Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro 
        675                 680                 685             


Tyr Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly 
    690                 695                 700                 


Ser Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg 
705                 710                 715                 720 


Lys Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe 
                725                 730                 735     


Trp Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr 
            740                 745                 750         


Arg Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser 
        755                 760                 765             


Met Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn 
    770                 775                 780                 


Gln His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val 
785                 790                 795                 800 


Asn Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe 
                805                 810                 815     


Thr Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu 
            820                 825                 830         


Lys Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro 
        835                 840                 845             


Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile 
    850                 855                 860                 


Gly Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp 
865                 870                 875                 880 


Val Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val 
                885                 890                 895     


Gln Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr 
            900                 905                 910         


Asn Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr 
        915                 920                 925             


Leu His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu 
    930                 935                 940                 


Glu Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln 
945                 950                 955                 960 


His Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn 
                965                 970                 975     


Val Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu 
            980                 985                 990         


Met Ser Lys Glu Ser Glu His Asp  Ser Asp Glu Ser Ser  Asp Asp Asp 
        995                 1000                 1005             


Ser Asp  Ser Glu Glu Pro Ser  Lys Tyr Ile Asn Ala  Ser Phe Ile 
    1010                 1015                 1020             


Met Ser  Tyr Trp Lys Pro Glu  Val Met Ile Ala Ala  Gln Gly Pro 
    1025                 1030                 1035             


Leu Lys  Glu Thr Ile Gly Asp  Phe Trp Gln Met Ile  Phe Gln Arg 
    1040                 1045                 1050             


Lys Val  Lys Val Ile Val Met  Leu Thr Glu Leu Lys  His Gly Asp 
    1055                 1060                 1065             


Gln Glu  Ile Cys Ala Gln Tyr  Trp Gly Glu Gly Lys  Gln Thr Tyr 
    1070                 1075                 1080             


Gly Asp  Ile Glu Val Asp Leu  Lys Asp Thr Asp Lys  Ser Ser Thr 
    1085                 1090                 1095             


Tyr Thr  Leu Arg Val Phe Glu  Leu Arg His Ser Lys  Arg Lys Asp 
    1100                 1105                 1110             


Ser Arg  Thr Val Tyr Gln Tyr  Gln Tyr Thr Asn Trp  Ser Val Glu 
    1115                 1120                 1125             


Gln Leu  Pro Ala Glu Pro Lys  Glu Leu Ile Ser Met  Ile Gln Val 
    1130                 1135                 1140             


Val Lys  Gln Lys Leu Pro Gln  Lys Asn Ser Ser Glu  Gly Asn Lys 
    1145                 1150                 1155             


His His  Lys Ser Thr Pro Leu  Leu Ile His Cys Arg  Asp Gly Ser 
    1160                 1165                 1170             


Gln Gln  Thr Gly Ile Phe Cys  Ala Leu Leu Asn Leu  Leu Glu Ser 
    1175                 1180                 1185             


Ala Glu  Thr Glu Glu Val Val  Asp Ile Phe Gln Val  Val Lys Ala 
    1190                 1195                 1200             


Leu Arg  Lys Ala Arg Pro Gly  Met Val Ser Thr Phe  Glu Gln Tyr 
    1205                 1210                 1215             


Gln Phe  Leu Tyr Asp Val Ile  Ala Ser Thr Tyr Pro  Ala Gln Asn 
    1220                 1225                 1230             


Gly Gln  Val Lys Lys Asn Asn  His Gln Glu Asp Lys  Ile Glu Phe 
    1235                 1240                 1245             


Asp Asn  Glu Val Asp Lys Val  Lys Gln Asp Ala Asn  Cys Val Asn 
    1250                 1255                 1260             


Pro Leu  Gly Ala Pro Glu Lys  Leu Pro Glu Ala Lys  Glu Gln Ala 
    1265                 1270                 1275             


Glu Gly  Ser Glu Pro Thr Ser  Gly Thr Glu Gly Pro  Glu His Ser 
    1280                 1285                 1290             


Val Asn  Gly Pro Ala Ser Pro  Ala Leu Asn Gln Gly  Ser 
    1295                 1300                 1305     


<210>  2716
<211>  1912
<212>  PRT
<213>  Homo sapiens

<400>  2716

Met Val His Val Ala Arg Leu Leu Leu Leu Leu Leu Thr Phe Phe Leu 
1               5                   10                  15      


Arg Thr Asp Ala Glu Thr Pro Pro Arg Phe Thr Arg Thr Pro Val Asp 
            20                  25                  30          


Gln Thr Gly Val Ser Gly Gly Val Ala Ser Phe Ile Cys Gln Ala Thr 
        35                  40                  45              


Gly Asp Pro Arg Pro Lys Ile Val Trp Asn Lys Lys Gly Lys Lys Val 
    50                  55                  60                  


Ser Asn Gln Arg Phe Glu Val Ile Glu Phe Asp Asp Gly Ser Gly Ser 
65                  70                  75                  80  


Val Leu Arg Ile Gln Pro Leu Arg Thr Pro Arg Asp Glu Ala Ile Tyr 
                85                  90                  95      


Glu Cys Val Ala Ser Asn Asn Val Gly Glu Ile Ser Val Ser Thr Arg 
            100                 105                 110         


Leu Thr Val Leu Arg Glu Asp Gln Ile Pro Arg Gly Phe Pro Thr Ile 
        115                 120                 125             


Asp Met Gly Pro Gln Leu Lys Val Val Glu Arg Thr Arg Thr Ala Thr 
    130                 135                 140                 


Met Leu Cys Ala Ala Ser Gly Asn Pro Asp Pro Glu Ile Thr Trp Phe 
145                 150                 155                 160 


Lys Asp Phe Leu Pro Val Asp Thr Ser Asn Asn Asn Gly Arg Ile Lys 
                165                 170                 175     


Gln Leu Arg Ser Glu Ser Ile Gly Gly Thr Pro Ile Arg Gly Ala Leu 
            180                 185                 190         


Gln Ile Glu Gln Ser Glu Glu Ser Asp Gln Gly Lys Tyr Glu Cys Val 
        195                 200                 205             


Ala Thr Asn Ser Ala Gly Thr Arg Tyr Ser Ala Pro Ala Asn Leu Tyr 
    210                 215                 220                 


Val Arg Glu Leu Arg Glu Val Arg Arg Val Pro Pro Arg Phe Ser Ile 
225                 230                 235                 240 


Pro Pro Thr Asn His Glu Ile Met Pro Gly Gly Ser Val Asn Ile Thr 
                245                 250                 255     


Cys Val Ala Val Gly Ser Pro Met Pro Tyr Val Lys Trp Met Leu Gly 
            260                 265                 270         


Ala Glu Asp Leu Thr Pro Glu Asp Asp Met Pro Ile Gly Arg Asn Val 
        275                 280                 285             


Leu Glu Leu Asn Asp Val Arg Gln Ser Ala Asn Tyr Thr Cys Val Ala 
    290                 295                 300                 


Met Ser Thr Leu Gly Val Ile Glu Ala Ile Ala Gln Ile Thr Val Lys 
305                 310                 315                 320 


Ala Leu Pro Lys Pro Pro Gly Thr Pro Val Val Thr Glu Ser Thr Ala 
                325                 330                 335     


Thr Ser Ile Thr Leu Thr Trp Asp Ser Gly Asn Pro Glu Pro Val Ser 
            340                 345                 350         


Tyr Tyr Ile Ile Gln His Lys Pro Lys Asn Ser Glu Glu Leu Tyr Lys 
        355                 360                 365             


Glu Ile Asp Gly Val Ala Thr Thr Arg Tyr Ser Val Ala Gly Leu Ser 
    370                 375                 380                 


Pro Tyr Ser Asp Tyr Glu Phe Arg Val Val Ala Val Asn Asn Ile Gly 
385                 390                 395                 400 


Arg Gly Pro Pro Ser Glu Pro Val Leu Thr Gln Thr Ser Glu Gln Ala 
                405                 410                 415     


Pro Ser Ser Ala Pro Arg Asp Val Gln Ala Arg Met Leu Ser Ser Thr 
            420                 425                 430         


Thr Ile Leu Val Gln Trp Lys Glu Pro Glu Glu Pro Asn Gly Gln Ile 
        435                 440                 445             


Gln Gly Tyr Arg Val Tyr Tyr Thr Met Asp Pro Thr Gln His Val Asn 
    450                 455                 460                 


Asn Trp Met Lys His Asn Val Ala Asp Ser Gln Ile Thr Thr Ile Gly 
465                 470                 475                 480 


Asn Leu Val Pro Gln Lys Thr Tyr Ser Val Lys Val Leu Ala Phe Thr 
                485                 490                 495     


Ser Ile Gly Asp Gly Pro Leu Ser Ser Asp Ile Gln Val Ile Thr Gln 
            500                 505                 510         


Thr Gly Val Pro Gly Gln Pro Leu Asn Phe Lys Ala Glu Pro Glu Ser 
        515                 520                 525             


Glu Thr Ser Ile Leu Leu Ser Trp Thr Pro Pro Arg Ser Asp Thr Ile 
    530                 535                 540                 


Ala Asn Tyr Glu Leu Val Tyr Lys Asp Gly Glu His Gly Glu Glu Gln 
545                 550                 555                 560 


Arg Ile Thr Ile Glu Pro Gly Thr Ser Tyr Arg Leu Gln Gly Leu Lys 
                565                 570                 575     


Pro Asn Ser Leu Tyr Tyr Phe Arg Leu Ala Ala Arg Ser Pro Gln Gly 
            580                 585                 590         


Leu Gly Ala Ser Thr Ala Glu Ile Ser Ala Arg Thr Met Gln Ser Lys 
        595                 600                 605             


Pro Ser Ala Pro Pro Gln Asp Ile Ser Cys Thr Ser Pro Ser Ser Thr 
    610                 615                 620                 


Ser Ile Leu Val Ser Trp Gln Pro Pro Pro Val Glu Lys Gln Asn Gly 
625                 630                 635                 640 


Ile Ile Thr Glu Tyr Ser Ile Lys Tyr Thr Ala Val Asp Gly Glu Asp 
                645                 650                 655     


Asp Lys Pro His Glu Ile Leu Gly Ile Pro Ser Asp Thr Thr Lys Tyr 
            660                 665                 670         


Leu Leu Glu Gln Leu Glu Lys Trp Thr Glu Tyr Arg Ile Thr Val Thr 
        675                 680                 685             


Ala His Thr Asp Val Gly Pro Gly Pro Glu Ser Leu Ser Val Leu Ile 
    690                 695                 700                 


Arg Thr Asn Glu Asp Val Pro Ser Gly Pro Pro Arg Lys Val Glu Val 
705                 710                 715                 720 


Glu Ala Val Asn Ser Thr Ser Val Lys Val Ser Trp Arg Ser Pro Val 
                725                 730                 735     


Pro Asn Lys Gln His Gly Gln Ile Arg Gly Tyr Gln Val His Tyr Val 
            740                 745                 750         


Arg Met Glu Asn Gly Glu Pro Lys Gly Gln Pro Met Leu Lys Asp Val 
        755                 760                 765             


Met Leu Ala Asp Ala Gln Trp Glu Phe Asp Asp Thr Thr Glu His Asp 
    770                 775                 780                 


Met Ile Ile Ser Gly Leu Gln Pro Glu Thr Ser Tyr Ser Leu Thr Val 
785                 790                 795                 800 


Thr Ala Tyr Thr Thr Lys Gly Asp Gly Ala Arg Ser Lys Pro Lys Leu 
                805                 810                 815     


Val Ser Thr Thr Gly Ala Val Pro Gly Lys Pro Arg Leu Val Ile Asn 
            820                 825                 830         


His Thr Gln Met Asn Thr Ala Leu Ile Gln Trp His Pro Pro Val Asp 
        835                 840                 845             


Thr Phe Gly Pro Leu Gln Gly Tyr Arg Leu Lys Phe Gly Arg Lys Asp 
    850                 855                 860                 


Met Glu Pro Leu Thr Thr Leu Glu Phe Ser Glu Lys Glu Asp His Phe 
865                 870                 875                 880 


Thr Ala Thr Asp Ile His Lys Gly Ala Ser Tyr Val Phe Arg Leu Ser 
                885                 890                 895     


Ala Arg Asn Lys Val Gly Phe Gly Glu Glu Met Val Lys Glu Ile Ser 
            900                 905                 910         


Ile Pro Glu Glu Val Pro Thr Gly Phe Pro Gln Asn Leu His Ser Glu 
        915                 920                 925             


Gly Thr Thr Ser Thr Ser Val Gln Leu Ser Trp Gln Pro Pro Val Leu 
    930                 935                 940                 


Ala Glu Arg Asn Gly Ile Ile Thr Lys Tyr Thr Leu Leu Tyr Arg Asp 
945                 950                 955                 960 


Ile Asn Ile Pro Leu Leu Pro Met Glu Gln Leu Ile Val Pro Ala Asp 
                965                 970                 975     


Thr Thr Met Thr Leu Thr Gly Leu Lys Pro Asp Thr Thr Tyr Asp Val 
            980                 985                 990         


Lys Val Arg Ala His Thr Ser Lys  Gly Pro Gly Pro Tyr  Ser Pro Ser 
        995                 1000                 1005             


Val Gln  Phe Arg Thr Leu Pro  Val Asp Gln Val Phe  Ala Lys Asn 
    1010                 1015                 1020             


Phe His  Val Lys Ala Val Met  Lys Thr Ser Val Leu  Leu Ser Trp 
    1025                 1030                 1035             


Glu Ile  Pro Glu Asn Tyr Asn  Ser Ala Met Pro Phe  Lys Ile Leu 
    1040                 1045                 1050             


Tyr Asp  Asp Gly Lys Met Val  Glu Glu Val Asp Gly  Arg Ala Thr 
    1055                 1060                 1065             


Gln Lys  Leu Ile Val Asn Leu  Lys Pro Glu Lys Ser  Tyr Ser Phe 
    1070                 1075                 1080             


Val Leu  Thr Asn Arg Gly Asn  Ser Ala Gly Gly Leu  Gln His Arg 
    1085                 1090                 1095             


Val Thr  Ala Lys Thr Ala Pro  Asp Val Leu Arg Thr  Lys Pro Ala 
    1100                 1105                 1110             


Phe Ile  Gly Lys Thr Asn Leu  Asp Gly Met Ile Thr  Val Gln Leu 
    1115                 1120                 1125             


Pro Glu  Val Pro Ala Asn Glu  Asn Ile Lys Gly Tyr  Tyr Ile Ile 
    1130                 1135                 1140             


Ile Val  Pro Leu Lys Lys Ser  Arg Gly Lys Phe Ile  Lys Pro Trp 
    1145                 1150                 1155             


Glu Ser  Pro Asp Glu Met Glu  Leu Asp Glu Leu Leu  Lys Glu Ile 
    1160                 1165                 1170             


Ser Arg  Lys Arg Arg Ser Ile  Arg Tyr Gly Arg Glu  Val Glu Leu 
    1175                 1180                 1185             


Lys Pro  Tyr Ile Ala Ala His  Phe Asp Val Leu Pro  Thr Glu Phe 
    1190                 1195                 1200             


Thr Leu  Gly Asp Asp Lys His  Tyr Gly Gly Phe Thr  Asn Lys Gln 
    1205                 1210                 1215             


Leu Gln  Ser Gly Gln Glu Tyr  Val Phe Phe Val Leu  Ala Val Met 
    1220                 1225                 1230             


Glu His  Ala Glu Ser Lys Met  Tyr Ala Thr Ser Pro  Tyr Ser Asp 
    1235                 1240                 1245             


Pro Val  Val Ser Met Asp Leu  Asp Pro Gln Pro Ile  Thr Asp Glu 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Trp Val  Val Gly Pro Val Leu  Ala Val Val 
    1265                 1270                 1275             


Phe Ile  Ile Cys Ile Val Ile  Ala Ile Leu Leu Tyr  Lys Arg Lys 
    1280                 1285                 1290             


Arg Ala  Glu Ser Asp Ser Arg  Lys Ser Ser Ile Pro  Asn Asn Lys 
    1295                 1300                 1305             


Glu Ile  Pro Ser His His Pro  Thr Asp Pro Val Glu  Leu Arg Arg 
    1310                 1315                 1320             


Leu Asn  Phe Gln Thr Pro Gly  Met Ala Ser His Pro  Pro Ile Pro 
    1325                 1330                 1335             


Ile Leu  Glu Leu Ala Asp His  Ile Glu Arg Leu Lys  Ala Asn Asp 
    1340                 1345                 1350             


Asn Leu  Lys Phe Ser Gln Glu  Tyr Glu Ser Ile Asp  Pro Gly Gln 
    1355                 1360                 1365             


Gln Phe  Thr Trp Glu His Ser  Asn Leu Glu Val Asn  Lys Pro Lys 
    1370                 1375                 1380             


Asn Arg  Tyr Ala Asn Val Ile  Ala Tyr Asp His Ser  Arg Val Leu 
    1385                 1390                 1395             


Leu Ser  Ala Ile Glu Gly Ile  Pro Gly Ser Asp Tyr  Val Asn Ala 
    1400                 1405                 1410             


Asn Tyr  Ile Asp Gly Tyr Arg  Lys Gln Asn Ala Tyr  Ile Ala Thr 
    1415                 1420                 1425             


Gln Gly  Ser Leu Pro Glu Thr  Phe Gly Asp Phe Trp  Arg Met Ile 
    1430                 1435                 1440             


Trp Glu  Gln Arg Ser Ala Thr  Val Val Met Met Thr  Lys Leu Glu 
    1445                 1450                 1455             


Glu Arg  Ser Arg Val Lys Cys  Asp Gln Tyr Trp Pro  Ser Arg Gly 
    1460                 1465                 1470             


Thr Glu  Thr His Gly Leu Val  Gln Val Thr Leu Leu  Asp Thr Val 
    1475                 1480                 1485             


Glu Leu  Ala Thr Tyr Cys Val  Arg Thr Phe Ala Leu  Tyr Lys Asn 
    1490                 1495                 1500             


Gly Ser  Ser Glu Lys Arg Glu  Val Arg Gln Phe Gln  Phe Thr Ala 
    1505                 1510                 1515             


Trp Pro  Asp His Gly Val Pro  Glu His Pro Thr Pro  Phe Leu Ala 
    1520                 1525                 1530             


Phe Leu  Arg Arg Val Lys Thr  Cys Asn Pro Pro Asp  Ala Gly Pro 
    1535                 1540                 1545             


Met Val  Val His Cys Ser Ala  Gly Val Gly Arg Thr  Gly Cys Phe 
    1550                 1555                 1560             


Ile Val  Ile Asp Ala Met Leu  Glu Arg Ile Lys His  Glu Lys Thr 
    1565                 1570                 1575             


Val Asp  Ile Tyr Gly His Val  Thr Leu Met Arg Ala  Gln Arg Asn 
    1580                 1585                 1590             


Tyr Met  Val Gln Thr Glu Asp  Gln Tyr Ile Phe Ile  His Asp Ala 
    1595                 1600                 1605             


Leu Leu  Glu Ala Val Thr Cys  Gly Asn Thr Glu Val  Pro Ala Arg 
    1610                 1615                 1620             


Asn Leu  Tyr Ala Tyr Ile Gln  Lys Leu Thr Gln Ile  Glu Thr Gly 
    1625                 1630                 1635             


Glu Asn  Val Thr Gly Met Glu  Leu Glu Phe Lys Arg  Leu Ala Ser 
    1640                 1645                 1650             


Ser Lys  Ala His Thr Ser Arg  Phe Ile Ser Ala Asn  Leu Pro Cys 
    1655                 1660                 1665             


Asn Lys  Phe Lys Asn Arg Leu  Val Asn Ile Met Pro  Tyr Glu Ser 
    1670                 1675                 1680             


Thr Arg  Val Cys Leu Gln Pro  Ile Arg Gly Val Glu  Gly Ser Asp 
    1685                 1690                 1695             


Tyr Ile  Asn Ala Ser Phe Ile  Asp Gly Tyr Arg Gln  Gln Lys Ala 
    1700                 1705                 1710             


Tyr Ile  Ala Thr Gln Gly Pro  Leu Ala Glu Thr Thr  Glu Asp Phe 
    1715                 1720                 1725             


Trp Arg  Met Leu Trp Glu His  Asn Ser Thr Ile Val  Val Met Leu 
    1730                 1735                 1740             


Thr Lys  Leu Arg Glu Met Gly  Arg Glu Lys Cys His  Gln Tyr Trp 
    1745                 1750                 1755             


Pro Ala  Glu Arg Ser Ala Arg  Tyr Gln Tyr Phe Val  Val Asp Pro 
    1760                 1765                 1770             


Met Ala  Glu Tyr Asn Met Pro  Gln Tyr Ile Leu Arg  Glu Phe Lys 
    1775                 1780                 1785             


Val Thr  Asp Ala Arg Asp Gly  Gln Ser Arg Thr Val  Arg Gln Phe 
    1790                 1795                 1800             


Gln Phe  Thr Asp Trp Pro Glu  Gln Gly Val Pro Lys  Ser Gly Glu 
    1805                 1810                 1815             


Gly Phe  Ile Asp Phe Ile Gly  Gln Val His Lys Thr  Lys Glu Gln 
    1820                 1825                 1830             


Phe Gly  Gln Asp Gly Pro Ile  Ser Val His Cys Ser  Ala Gly Val 
    1835                 1840                 1845             


Gly Arg  Thr Gly Val Phe Ile  Thr Leu Ser Ile Val  Leu Glu Arg 
    1850                 1855                 1860             


Met Arg  Tyr Glu Gly Val Val  Asp Ile Phe Gln Thr  Val Lys Met 
    1865                 1870                 1875             


Leu Arg  Thr Gln Arg Pro Ala  Met Val Gln Thr Glu  Asp Gln Tyr 
    1880                 1885                 1890             


Gln Phe  Ser Tyr Arg Ala Ala  Leu Glu Tyr Leu Gly  Ser Phe Asp 
    1895                 1900                 1905             


His Tyr  Ala Thr 
    1910         


<210>  2717
<211>  1907
<212>  PRT
<213>  Homo sapiens

<400>  2717

Met Ala Pro Glu Pro Ala Pro Gly Arg Thr Met Val Pro Leu Val Pro 
1               5                   10                  15      


Ala Leu Val Met Leu Gly Leu Val Ala Gly Ala His Gly Asp Ser Lys 
            20                  25                  30          


Pro Val Phe Ile Lys Val Pro Glu Asp Gln Thr Gly Leu Ser Gly Gly 
        35                  40                  45              


Val Ala Ser Phe Val Cys Gln Ala Thr Gly Glu Pro Lys Pro Arg Ile 
    50                  55                  60                  


Thr Trp Met Lys Lys Gly Lys Lys Val Ser Ser Gln Arg Phe Glu Val 
65                  70                  75                  80  


Ile Glu Phe Asp Asp Gly Ala Gly Ser Val Leu Arg Ile Gln Pro Leu 
                85                  90                  95      


Arg Val Gln Arg Asp Glu Ala Ile Tyr Glu Cys Thr Ala Thr Asn Ser 
            100                 105                 110         


Leu Gly Glu Ile Asn Thr Ser Ala Lys Leu Ser Val Leu Glu Glu Glu 
        115                 120                 125             


Gln Leu Pro Pro Gly Phe Pro Ser Ile Asp Met Gly Pro Gln Leu Lys 
    130                 135                 140                 


Val Val Glu Lys Ala Arg Thr Ala Thr Met Leu Cys Ala Ala Gly Gly 
145                 150                 155                 160 


Asn Pro Asp Pro Glu Ile Ser Trp Phe Lys Asp Phe Leu Pro Val Asp 
                165                 170                 175     


Pro Ala Thr Ser Asn Gly Arg Ile Lys Gln Leu Arg Ser Gly Ala Leu 
            180                 185                 190         


Gln Ile Glu Ser Ser Glu Glu Ser Asp Gln Gly Lys Tyr Glu Cys Val 
        195                 200                 205             


Ala Thr Asn Ser Ala Gly Thr Arg Tyr Ser Ala Pro Ala Asn Leu Tyr 
    210                 215                 220                 


Val Arg Val Arg Arg Val Ala Pro Arg Phe Ser Ile Pro Pro Ser Ser 
225                 230                 235                 240 


Gln Glu Val Met Pro Gly Gly Ser Val Asn Leu Thr Cys Val Ala Val 
                245                 250                 255     


Gly Ala Pro Met Pro Tyr Val Lys Trp Met Met Gly Ala Glu Glu Leu 
            260                 265                 270         


Thr Lys Glu Asp Glu Met Pro Val Gly Arg Asn Val Leu Glu Leu Ser 
        275                 280                 285             


Asn Val Val Arg Ser Ala Asn Tyr Thr Cys Val Ala Ile Ser Ser Leu 
    290                 295                 300                 


Gly Met Ile Glu Ala Thr Ala Gln Val Thr Val Lys Ala Leu Pro Lys 
305                 310                 315                 320 


Pro Pro Ile Asp Leu Val Val Thr Glu Thr Thr Ala Thr Ser Val Thr 
                325                 330                 335     


Leu Thr Trp Asp Ser Gly Asn Ser Glu Pro Val Thr Tyr Tyr Gly Ile 
            340                 345                 350         


Gln Tyr Arg Ala Ala Gly Thr Glu Gly Pro Phe Gln Glu Val Asp Gly 
        355                 360                 365             


Val Ala Thr Thr Arg Tyr Ser Ile Gly Gly Leu Ser Pro Phe Ser Glu 
    370                 375                 380                 


Tyr Ala Phe Arg Val Leu Ala Val Asn Ser Ile Gly Arg Gly Pro Pro 
385                 390                 395                 400 


Ser Glu Ala Val Arg Ala Arg Thr Gly Glu Gln Ala Pro Ser Ser Pro 
                405                 410                 415     


Pro Arg Arg Val Gln Ala Arg Met Leu Ser Ala Ser Thr Met Leu Val 
            420                 425                 430         


Gln Trp Glu Pro Pro Glu Glu Pro Asn Gly Leu Val Arg Gly Tyr Arg 
        435                 440                 445             


Val Tyr Tyr Thr Pro Asp Ser Arg Arg Pro Pro Asn Ala Trp His Lys 
    450                 455                 460                 


His Asn Thr Asp Ala Gly Leu Leu Thr Thr Val Gly Ser Leu Leu Pro 
465                 470                 475                 480 


Gly Ile Thr Tyr Ser Leu Arg Val Leu Ala Phe Thr Ala Val Gly Asp 
                485                 490                 495     


Gly Pro Pro Ser Pro Thr Ile Gln Val Lys Thr Gln Gln Gly Val Pro 
            500                 505                 510         


Ala Gln Pro Ala Asp Phe Gln Ala Glu Val Glu Ser Asp Thr Arg Ile 
        515                 520                 525             


Gln Leu Ser Trp Leu Leu Pro Pro Gln Glu Arg Ile Ile Met Tyr Glu 
    530                 535                 540                 


Leu Val Tyr Trp Ala Ala Glu Asp Glu Asp Gln Gln His Lys Val Thr 
545                 550                 555                 560 


Phe Asp Pro Thr Ser Ser Tyr Thr Leu Glu Asp Leu Lys Pro Asp Thr 
                565                 570                 575     


Leu Tyr Arg Phe Gln Leu Ala Ala Arg Ser Asp Met Gly Val Gly Val 
            580                 585                 590         


Phe Thr Pro Thr Ile Glu Ala Arg Thr Ala Gln Ser Thr Pro Ser Ala 
        595                 600                 605             


Pro Pro Gln Lys Val Met Cys Val Ser Met Gly Ser Thr Thr Val Arg 
    610                 615                 620                 


Val Ser Trp Val Pro Pro Pro Ala Asp Ser Arg Asn Gly Val Ile Thr 
625                 630                 635                 640 


Gln Tyr Ser Val Ala Tyr Glu Ala Val Asp Gly Glu Asp Arg Gly Arg 
                645                 650                 655     


His Val Val Asp Gly Ile Ser Arg Glu His Ser Ser Trp Asp Leu Val 
            660                 665                 670         


Gly Leu Glu Lys Trp Thr Glu Tyr Arg Val Trp Val Arg Ala His Thr 
        675                 680                 685             


Asp Val Gly Pro Gly Pro Glu Ser Ser Pro Val Leu Val Arg Thr Asp 
    690                 695                 700                 


Glu Asp Val Pro Ser Gly Pro Pro Arg Lys Val Glu Val Glu Pro Leu 
705                 710                 715                 720 


Asn Ser Thr Ala Val His Val Tyr Trp Lys Leu Pro Val Pro Ser Lys 
                725                 730                 735     


Gln His Gly Gln Ile Arg Gly Tyr Gln Val Thr Tyr Val Arg Leu Glu 
            740                 745                 750         


Asn Gly Glu Pro Arg Gly Leu Pro Ile Ile Gln Asp Val Met Leu Ala 
        755                 760                 765             


Glu Ala Gln Trp Arg Pro Glu Glu Ser Glu Asp Tyr Glu Thr Thr Ile 
    770                 775                 780                 


Ser Gly Leu Thr Pro Glu Thr Thr Tyr Ser Val Thr Val Ala Ala Tyr 
785                 790                 795                 800 


Thr Thr Lys Gly Asp Gly Ala Arg Ser Lys Pro Lys Ile Val Thr Thr 
                805                 810                 815     


Thr Gly Ala Val Pro Gly Arg Pro Thr Met Met Ile Ser Thr Thr Ala 
            820                 825                 830         


Met Asn Thr Ala Leu Leu Gln Trp His Pro Pro Lys Glu Leu Pro Gly 
        835                 840                 845             


Glu Leu Leu Gly Tyr Arg Leu Gln Tyr Cys Arg Ala Asp Glu Ala Arg 
    850                 855                 860                 


Pro Asn Thr Ile Asp Phe Gly Lys Asp Asp Gln His Phe Thr Val Thr 
865                 870                 875                 880 


Gly Leu His Lys Gly Thr Thr Tyr Ile Phe Arg Leu Ala Ala Lys Asn 
                885                 890                 895     


Arg Ala Gly Leu Gly Glu Glu Phe Glu Lys Glu Ile Arg Thr Pro Glu 
            900                 905                 910         


Asp Leu Pro Ser Gly Phe Pro Gln Asn Leu His Val Thr Gly Leu Thr 
        915                 920                 925             


Thr Ser Thr Thr Glu Leu Ala Trp Asp Pro Pro Val Leu Ala Glu Arg 
    930                 935                 940                 


Asn Gly Arg Ile Ile Ser Tyr Thr Val Val Phe Arg Asp Ile Asn Ser 
945                 950                 955                 960 


Gln Gln Glu Leu Gln Asn Ile Thr Thr Asp Thr Arg Phe Thr Leu Thr 
                965                 970                 975     


Gly Leu Lys Pro Asp Thr Thr Tyr Asp Ile Lys Val Arg Ala Trp Thr 
            980                 985                 990         


Ser Lys Gly Ser Gly Pro Leu Ser  Pro Ser Ile Gln Ser  Arg Thr Met 
        995                 1000                 1005             


Pro Val  Glu Gln Val Phe Ala  Lys Asn Phe Arg Val  Ala Ala Ala 
    1010                 1015                 1020             


Met Lys  Thr Ser Val Leu Leu  Ser Trp Glu Val Pro  Asp Ser Tyr 
    1025                 1030                 1035             


Lys Ser  Ala Val Pro Phe Lys  Ile Leu Tyr Asn Gly  Gln Ser Val 
    1040                 1045                 1050             


Glu Val  Asp Gly His Ser Met  Arg Lys Leu Ile Ala  Asp Leu Gln 
    1055                 1060                 1065             


Pro Asn  Thr Glu Tyr Ser Phe  Val Leu Met Asn Arg  Gly Ser Ser 
    1070                 1075                 1080             


Ala Gly  Gly Leu Gln His Leu  Val Ser Ile Arg Thr  Ala Pro Asp 
    1085                 1090                 1095             


Leu Leu  Pro His Lys Pro Leu  Pro Ala Ser Ala Tyr  Ile Glu Asp 
    1100                 1105                 1110             


Gly Arg  Phe Asp Leu Ser Met  Pro His Val Gln Asp  Pro Ser Leu 
    1115                 1120                 1125             


Val Arg  Trp Phe Tyr Ile Val  Val Val Pro Ile Asp  Arg Val Gly 
    1130                 1135                 1140             


Gly Ser  Met Leu Thr Pro Arg  Trp Ser Thr Pro Glu  Glu Leu Glu 
    1145                 1150                 1155             


Leu Asp  Glu Leu Leu Glu Ala  Ile Glu Gln Gly Gly  Glu Glu Gln 
    1160                 1165                 1170             


Arg Arg  Arg Arg Arg Gln Ala  Glu Arg Leu Lys Pro  Tyr Val Ala 
    1175                 1180                 1185             


Ala Gln  Leu Asp Val Leu Pro  Glu Thr Phe Thr Leu  Gly Asp Lys 
    1190                 1195                 1200             


Lys Asn  Tyr Arg Gly Phe Tyr  Asn Arg Pro Leu Ser  Pro Asp Leu 
    1205                 1210                 1215             


Ser Tyr  Gln Cys Phe Val Leu  Ala Ser Leu Lys Glu  Pro Met Asp 
    1220                 1225                 1230             


Gln Lys  Arg Tyr Ala Ser Ser  Pro Tyr Ser Asp Glu  Ile Val Val 
    1235                 1240                 1245             


Gln Val  Thr Pro Ala Gln Gln  Gln Glu Glu Pro Glu  Met Leu Trp 
    1250                 1255                 1260             


Val Thr  Gly Pro Val Leu Ala  Val Ile Leu Ile Ile  Leu Ile Val 
    1265                 1270                 1275             


Ile Ala  Ile Leu Leu Phe Lys  Arg Lys Arg Thr His  Ser Pro Ser 
    1280                 1285                 1290             


Ser Lys  Asp Glu Gln Ser Ile  Gly Leu Lys Asp Ser  Leu Leu Ala 
    1295                 1300                 1305             


His Ser  Ser Asp Pro Val Glu  Met Arg Arg Leu Asn  Tyr Gln Thr 
    1310                 1315                 1320             


Pro Gly  Met Arg Asp His Pro  Pro Ile Pro Ile Thr  Asp Leu Ala 
    1325                 1330                 1335             


Asp Asn  Ile Glu Arg Leu Lys  Ala Asn Asp Gly Leu  Lys Phe Ser 
    1340                 1345                 1350             


Gln Glu  Tyr Glu Ser Ile Asp  Pro Gly Gln Gln Phe  Thr Trp Glu 
    1355                 1360                 1365             


Asn Ser  Asn Leu Glu Val Asn  Lys Pro Lys Asn Arg  Tyr Ala Asn 
    1370                 1375                 1380             


Val Ile  Ala Tyr Asp His Ser  Arg Val Ile Leu Thr  Ser Ile Asp 
    1385                 1390                 1395             


Gly Val  Pro Gly Ser Asp Tyr  Ile Asn Ala Asn Tyr  Ile Asp Gly 
    1400                 1405                 1410             


Tyr Arg  Lys Gln Asn Ala Tyr  Ile Ala Thr Gln Gly  Pro Leu Pro 
    1415                 1420                 1425             


Glu Thr  Met Gly Asp Phe Trp  Arg Met Val Trp Glu  Gln Arg Thr 
    1430                 1435                 1440             


Ala Thr  Val Val Met Met Thr  Arg Leu Glu Glu Lys  Ser Arg Val 
    1445                 1450                 1455             


Lys Cys  Asp Gln Tyr Trp Pro  Ala Arg Gly Thr Glu  Thr Cys Gly 
    1460                 1465                 1470             


Leu Ile  Gln Val Thr Leu Leu  Asp Thr Val Glu Leu  Ala Thr Tyr 
    1475                 1480                 1485             


Thr Val  Arg Thr Phe Ala Leu  His Lys Ser Gly Ser  Ser Glu Lys 
    1490                 1495                 1500             


Arg Glu  Leu Arg Gln Phe Gln  Phe Met Ala Trp Pro  Asp His Gly 
    1505                 1510                 1515             


Val Pro  Glu Tyr Pro Thr Pro  Ile Leu Ala Phe Leu  Arg Arg Val 
    1520                 1525                 1530             


Lys Ala  Cys Asn Pro Leu Asp  Ala Gly Pro Met Val  Val His Cys 
    1535                 1540                 1545             


Ser Ala  Gly Val Gly Arg Thr  Gly Cys Phe Ile Val  Ile Asp Ala 
    1550                 1555                 1560             


Met Leu  Glu Arg Met Lys His  Glu Lys Thr Val Asp  Ile Tyr Gly 
    1565                 1570                 1575             


His Val  Thr Cys Met Arg Ser  Gln Arg Asn Tyr Met  Val Gln Thr 
    1580                 1585                 1590             


Glu Asp  Gln Tyr Val Phe Ile  His Glu Ala Leu Leu  Glu Ala Ala 
    1595                 1600                 1605             


Thr Cys  Gly His Thr Glu Val  Pro Ala Arg Asn Leu  Tyr Ala His 
    1610                 1615                 1620             


Ile Gln  Lys Leu Gly Gln Val  Pro Pro Gly Glu Ser  Val Thr Ala 
    1625                 1630                 1635             


Met Glu  Leu Glu Phe Lys Leu  Leu Ala Ser Ser Lys  Ala His Thr 
    1640                 1645                 1650             


Ser Arg  Phe Ile Ser Ala Asn  Leu Pro Cys Asn Lys  Phe Lys Asn 
    1655                 1660                 1665             


Arg Leu  Val Asn Ile Met Pro  Tyr Glu Leu Thr Arg  Val Cys Leu 
    1670                 1675                 1680             


Gln Pro  Ile Arg Gly Val Glu  Gly Ser Asp Tyr Ile  Asn Ala Ser 
    1685                 1690                 1695             


Phe Leu  Asp Gly Tyr Arg Gln  Gln Lys Ala Tyr Ile  Ala Thr Gln 
    1700                 1705                 1710             


Gly Pro  Leu Ala Glu Ser Thr  Glu Asp Phe Trp Arg  Met Leu Trp 
    1715                 1720                 1725             


Glu His  Asn Ser Thr Ile Ile  Val Met Leu Thr Lys  Leu Arg Glu 
    1730                 1735                 1740             


Met Gly  Arg Glu Lys Cys His  Gln Tyr Trp Pro Ala  Glu Arg Ser 
    1745                 1750                 1755             


Ala Arg  Tyr Gln Tyr Phe Val  Val Asp Pro Met Ala  Glu Tyr Asn 
    1760                 1765                 1770             


Met Pro  Gln Tyr Ile Leu Arg  Glu Phe Lys Val Thr  Asp Ala Arg 
    1775                 1780                 1785             


Asp Gly  Gln Ser Arg Thr Ile  Arg Gln Phe Gln Phe  Thr Asp Trp 
    1790                 1795                 1800             


Pro Glu  Gln Gly Val Pro Lys  Thr Gly Glu Gly Phe  Ile Asp Phe 
    1805                 1810                 1815             


Ile Gly  Gln Val His Lys Thr  Lys Glu Gln Phe Gly  Gln Asp Gly 
    1820                 1825                 1830             


Pro Ile  Thr Val His Cys Ser  Ala Gly Val Gly Arg  Thr Gly Val 
    1835                 1840                 1845             


Phe Ile  Thr Leu Ser Ile Val  Leu Glu Arg Met Arg  Tyr Glu Gly 
    1850                 1855                 1860             


Val Val  Asp Met Phe Gln Thr  Val Lys Thr Leu Arg  Thr Gln Arg 
    1865                 1870                 1875             


Pro Ala  Met Val Gln Thr Glu  Asp Gln Tyr Gln Leu  Cys Tyr Arg 
    1880                 1885                 1890             


Ala Ala  Leu Glu Tyr Leu Gly  Ser Phe Asp His Tyr  Ala Thr 
    1895                 1900                 1905         


<210>  2718
<211>  1445
<212>  PRT
<213>  Homo sapiens

<400>  2718

Met Arg Arg Leu Leu Glu Pro Cys Trp Trp Ile Leu Phe Leu Lys Ile 
1               5                   10                  15      


Thr Ser Ser Val Leu His Tyr Val Val Cys Phe Pro Ala Leu Thr Glu 
            20                  25                  30          


Gly Tyr Val Gly Ala Leu His Glu Asn Arg His Gly Ser Ala Val Gln 
        35                  40                  45              


Ile Arg Arg Arg Lys Ala Ser Gly Asp Pro Tyr Trp Ala Tyr Ser Gly 
    50                  55                  60                  


Ala Tyr Gly Pro Glu His Trp Val Thr Ser Ser Val Ser Cys Gly Gly 
65                  70                  75                  80  


Arg His Gln Ser Pro Ile Asp Ile Leu Asp Gln Tyr Ala Arg Val Gly 
                85                  90                  95      


Glu Glu Tyr Gln Glu Leu Gln Leu Asp Gly Phe Asp Asn Glu Ser Ser 
            100                 105                 110         


Asn Lys Thr Trp Met Lys Asn Thr Gly Lys Thr Val Ala Ile Leu Leu 
        115                 120                 125             


Lys Asp Asp Tyr Phe Val Ser Gly Ala Gly Leu Pro Gly Arg Phe Lys 
    130                 135                 140                 


Ala Glu Lys Val Glu Phe His Trp Gly His Ser Asn Gly Ser Ala Gly 
145                 150                 155                 160 


Ser Glu His Ser Ile Asn Gly Arg Arg Phe Pro Val Glu Met Gln Ile 
                165                 170                 175     


Phe Phe Tyr Asn Pro Asp Asp Phe Asp Ser Phe Gln Thr Ala Ile Ser 
            180                 185                 190         


Glu Asn Arg Ile Ile Gly Ala Met Ala Ile Phe Phe Gln Val Ser Pro 
        195                 200                 205             


Arg Asp Asn Ser Ala Leu Asp Pro Ile Ile His Gly Leu Lys Gly Val 
    210                 215                 220                 


Val His His Glu Lys Glu Thr Phe Leu Asp Pro Phe Val Leu Arg Asp 
225                 230                 235                 240 


Leu Leu Pro Ala Ser Leu Gly Ser Tyr Tyr Arg Tyr Thr Gly Ser Leu 
                245                 250                 255     


Thr Thr Pro Pro Cys Ser Glu Ile Val Glu Trp Ile Val Phe Arg Arg 
            260                 265                 270         


Pro Val Pro Ile Ser Tyr His Gln Leu Glu Ala Phe Tyr Ser Ile Phe 
        275                 280                 285             


Thr Thr Glu Gln Gln Asp His Val Lys Ser Val Glu Tyr Leu Arg Asn 
    290                 295                 300                 


Asn Phe Arg Pro Gln Gln Arg Leu His Asp Arg Val Val Ser Lys Ser 
305                 310                 315                 320 


Ala Val Arg Asp Ser Trp Asn His Asp Met Thr Asp Phe Leu Glu Asn 
                325                 330                 335     


Pro Leu Gly Thr Glu Ala Ser Lys Val Cys Ser Ser Pro Pro Ile His 
            340                 345                 350         


Met Lys Val Gln Pro Leu Asn Gln Thr Ala Leu Gln Val Ser Trp Ser 
        355                 360                 365             


Gln Pro Glu Thr Ile Tyr His Pro Pro Ile Met Asn Tyr Met Ile Ser 
    370                 375                 380                 


Tyr Ser Trp Thr Lys Asn Glu Asp Glu Lys Glu Lys Thr Phe Thr Lys 
385                 390                 395                 400 


Asp Ser Asp Lys Asp Leu Lys Ala Thr Ile Ser His Val Ser Pro Asp 
                405                 410                 415     


Ser Leu Tyr Leu Phe Arg Val Gln Ala Val Cys Arg Asn Asp Met Arg 
            420                 425                 430         


Ser Asp Phe Ser Gln Thr Met Leu Phe Gln Ala Asn Thr Thr Arg Ile 
        435                 440                 445             


Phe Gln Gly Thr Arg Ile Val Lys Thr Gly Val Pro Thr Ala Ser Pro 
    450                 455                 460                 


Ala Ser Ser Ala Asp Met Ala Pro Ile Ser Ser Gly Ser Ser Thr Trp 
465                 470                 475                 480 


Thr Ser Ser Gly Ile Pro Phe Ser Phe Val Ser Met Ala Thr Gly Met 
                485                 490                 495     


Gly Pro Ser Ser Ser Gly Ser Gln Ala Thr Val Ala Ser Val Val Thr 
            500                 505                 510         


Ser Thr Leu Leu Ala Gly Leu Gly Phe Gly Gly Gly Gly Ile Ser Ser 
        515                 520                 525             


Phe Pro Ser Thr Val Trp Pro Thr Arg Leu Pro Thr Ala Ala Ser Ala 
    530                 535                 540                 


Ser Lys Gln Ala Ala Arg Pro Val Leu Ala Thr Thr Glu Ala Leu Ala 
545                 550                 555                 560 


Ser Pro Gly Pro Asp Gly Asp Ser Ser Pro Thr Lys Asp Gly Glu Gly 
                565                 570                 575     


Thr Glu Glu Gly Glu Lys Asp Glu Lys Ser Glu Ser Glu Asp Gly Glu 
            580                 585                 590         


Arg Glu His Glu Glu Asp Gly Glu Lys Asp Ser Glu Lys Lys Glu Lys 
        595                 600                 605             


Ser Gly Val Thr His Ala Ala Glu Glu Arg Asn Gln Thr Glu Pro Ser 
    610                 615                 620                 


Pro Thr Pro Ser Ser Pro Asn Arg Thr Ala Glu Gly Gly His Gln Thr 
625                 630                 635                 640 


Ile Pro Gly His Glu Gln Asp His Thr Ala Val Pro Thr Asp Gln Thr 
                645                 650                 655     


Gly Gly Arg Arg Asp Ala Gly Pro Gly Leu Asp Pro Asp Met Val Thr 
            660                 665                 670         


Ser Thr Gln Val Pro Pro Thr Ala Thr Glu Glu Gln Tyr Ala Gly Ser 
        675                 680                 685             


Asp Pro Lys Arg Pro Glu Met Pro Ser Lys Lys Pro Met Ser Arg Gly 
    690                 695                 700                 


Asp Arg Phe Ser Glu Asp Ser Arg Phe Ile Thr Val Asn Pro Ala Glu 
705                 710                 715                 720 


Lys Asn Thr Ser Gly Met Ile Ser Arg Pro Ala Pro Gly Arg Met Glu 
                725                 730                 735     


Trp Ile Ile Pro Leu Ile Val Val Ser Ala Leu Thr Phe Val Cys Leu 
            740                 745                 750         


Ile Leu Leu Ile Ala Val Leu Val Tyr Trp Arg Gly Cys Asn Lys Ile 
        755                 760                 765             


Lys Ser Lys Gly Phe Pro Arg Arg Phe Arg Glu Val Pro Ser Ser Gly 
    770                 775                 780                 


Glu Arg Gly Glu Lys Gly Ser Arg Lys Cys Phe Gln Thr Ala His Phe 
785                 790                 795                 800 


Tyr Val Glu Asp Ser Ser Ser Pro Arg Val Val Pro Asn Glu Ser Ile 
                805                 810                 815     


Pro Ile Ile Pro Ile Pro Asp Asp Met Glu Ala Ile Pro Val Lys Gln 
            820                 825                 830         


Phe Val Lys His Ile Gly Glu Leu Tyr Ser Asn Asn Gln His Gly Phe 
        835                 840                 845             


Ser Glu Asp Phe Glu Glu Val Gln Arg Cys Thr Ala Asp Met Asn Ile 
    850                 855                 860                 


Thr Ala Glu His Ser Asn His Pro Glu Asn Lys His Lys Asn Arg Tyr 
865                 870                 875                 880 


Ile Asn Ile Leu Ala Tyr Asp His Ser Arg Val Lys Leu Arg Pro Leu 
                885                 890                 895     


Pro Gly Lys Asp Ser Lys His Ser Asp Tyr Ile Asn Ala Asn Tyr Val 
            900                 905                 910         


Asp Gly Tyr Asn Lys Ala Lys Ala Tyr Ile Ala Thr Gln Gly Pro Leu 
        915                 920                 925             


Lys Ser Thr Phe Glu Asp Phe Trp Arg Met Ile Trp Glu Gln Asn Thr 
    930                 935                 940                 


Gly Ile Ile Val Met Ile Thr Asn Leu Val Glu Lys Gly Arg Arg Lys 
945                 950                 955                 960 


Cys Asp Gln Tyr Trp Pro Thr Glu Asn Ser Glu Glu Tyr Gly Asn Ile 
                965                 970                 975     


Ile Val Thr Leu Lys Ser Thr Lys Ile His Ala Cys Tyr Thr Val Arg 
            980                 985                 990         


Arg Phe Ser Ile Arg Asn Thr Lys  Val Lys Lys Gly Gln  Lys Gly Asn 
        995                 1000                 1005             


Pro Lys  Gly Arg Gln Asn Glu  Arg Val Val Ile Gln  Tyr His Tyr 
    1010                 1015                 1020             


Thr Gln  Trp Pro Asp Met Gly  Val Pro Glu Tyr Ala  Leu Pro Val 
    1025                 1030                 1035             


Leu Thr  Phe Val Arg Arg Ser  Ser Ala Ala Arg Met  Pro Glu Thr 
    1040                 1045                 1050             


Gly Pro  Val Leu Val His Cys  Ser Ala Gly Val Gly  Arg Thr Gly 
    1055                 1060                 1065             


Thr Tyr  Ile Val Ile Asp Ser  Met Leu Gln Gln Ile  Lys Asp Lys 
    1070                 1075                 1080             


Ser Thr  Val Asn Val Leu Gly  Phe Leu Lys His Ile  Arg Thr Gln 
    1085                 1090                 1095             


Arg Asn  Tyr Leu Val Gln Thr  Glu Glu Gln Tyr Ile  Phe Ile His 
    1100                 1105                 1110             


Asp Ala  Leu Leu Glu Ala Ile  Leu Gly Lys Glu Thr  Glu Val Ser 
    1115                 1120                 1125             


Ser Asn  Gln Leu His Ser Tyr  Val Asn Ser Ile Leu  Ile Pro Gly 
    1130                 1135                 1140             


Val Gly  Gly Lys Thr Arg Leu  Glu Lys Gln Phe Lys  Leu Val Thr 
    1145                 1150                 1155             


Gln Cys  Asn Ala Lys Tyr Val  Glu Cys Phe Ser Ala  Gln Lys Glu 
    1160                 1165                 1170             


Cys Asn  Lys Glu Lys Asn Arg  Asn Ser Ser Val Val  Pro Ser Glu 
    1175                 1180                 1185             


Arg Ala  Arg Val Gly Leu Ala  Pro Leu Pro Gly Met  Lys Gly Thr 
    1190                 1195                 1200             


Asp Tyr  Ile Asn Ala Ser Tyr  Ile Met Gly Tyr Tyr  Arg Ser Asn 
    1205                 1210                 1215             


Glu Phe  Ile Ile Thr Gln His  Pro Leu Pro His Thr  Thr Lys Asp 
    1220                 1225                 1230             


Phe Trp  Arg Met Ile Trp Asp  His Asn Ala Gln Ile  Ile Val Met 
    1235                 1240                 1245             


Leu Pro  Asp Asn Gln Ser Leu  Ala Glu Asp Glu Phe  Val Tyr Trp 
    1250                 1255                 1260             


Pro Ser  Arg Glu Glu Ser Met  Asn Cys Glu Ala Phe  Thr Val Thr 
    1265                 1270                 1275             


Leu Ile  Ser Lys Asp Arg Leu  Cys Leu Ser Asn Glu  Glu Gln Ile 
    1280                 1285                 1290             


Ile Ile  His Asp Phe Ile Leu  Glu Ala Thr Gln Asp  Asp Tyr Val 
    1295                 1300                 1305             


Leu Glu  Val Arg His Phe Gln  Cys Pro Lys Trp Pro  Asn Pro Asp 
    1310                 1315                 1320             


Ala Pro  Ile Ser Ser Thr Phe  Glu Leu Ile Asn Val  Ile Lys Glu 
    1325                 1330                 1335             


Glu Ala  Leu Thr Arg Asp Gly  Pro Thr Ile Val His  Asp Glu Tyr 
    1340                 1345                 1350             


Gly Ala  Val Ser Ala Gly Met  Leu Cys Ala Leu Thr  Thr Leu Ser 
    1355                 1360                 1365             


Gln Gln  Leu Glu Asn Glu Asn  Ala Val Asp Val Phe  Gln Val Ala 
    1370                 1375                 1380             


Lys Met  Ile Asn Leu Met Arg  Pro Gly Val Phe Thr  Asp Ile Glu 
    1385                 1390                 1395             


Gln Tyr  Gln Phe Ile Tyr Lys  Ala Met Leu Ser Leu  Val Ser Thr 
    1400                 1405                 1410             


Lys Glu  Asn Gly Asn Gly Pro  Met Thr Val Asp Lys  Asn Gly Ala 
    1415                 1420                 1425             


Val Leu  Ile Ala Asp Glu Ser  Asp Pro Ala Glu Ser  Met Glu Ser 
    1430                 1435                 1440             


Leu Val  
    1445 


<210>  2719
<211>  1115
<212>  PRT
<213>  Homo sapiens

<400>  2719

Met Ala Gly Ala Gly Gly Gly Leu Gly Val Trp Gly Asn Leu Val Leu 
1               5                   10                  15      


Leu Gly Leu Cys Ser Trp Thr Gly Ala Arg Ala Pro Ala Pro Asn Pro 
            20                  25                  30          


Gly Arg Asn Leu Thr Val Glu Thr Gln Thr Thr Ser Ser Ile Ser Leu 
        35                  40                  45              


Ser Trp Glu Val Pro Asp Gly Leu Asp Ser Gln Asn Ser Asn Tyr Trp 
    50                  55                  60                  


Val Gln Cys Thr Gly Asp Gly Gly Thr Thr Glu Thr Arg Asn Thr Thr 
65                  70                  75                  80  


Ala Thr Asn Val Thr Val Asp Gly Leu Gly Pro Gly Ser Leu Tyr Thr 
                85                  90                  95      


Cys Ser Val Trp Val Glu Lys Asp Gly Val Asn Ser Ser Val Gly Thr 
            100                 105                 110         


Val Thr Thr Ala Thr Ala Pro Asn Pro Val Arg Asn Leu Arg Val Glu 
        115                 120                 125             


Ala Gln Thr Asn Ser Ser Ile Ala Leu Thr Trp Glu Val Pro Asp Gly 
    130                 135                 140                 


Pro Asp Pro Gln Asn Ser Thr Tyr Gly Val Glu Tyr Thr Gly Asp Gly 
145                 150                 155                 160 


Gly Arg Ala Gly Thr Arg Ser Thr Ala His Thr Asn Ile Thr Val Asp 
                165                 170                 175     


Gly Leu Glu Pro Gly Cys Leu Tyr Ala Phe Ser Met Trp Val Gly Lys 
            180                 185                 190         


Asn Gly Ile Asn Ser Ser Arg Glu Thr Arg Asn Ala Thr Thr Ala His 
        195                 200                 205             


Asn Pro Val Arg Asn Leu Arg Val Glu Ala Gln Thr Thr Ser Ser Ile 
    210                 215                 220                 


Ser Leu Ser Trp Glu Val Pro Asp Gly Thr Asp Pro Gln Asn Ser Thr 
225                 230                 235                 240 


Tyr Cys Val Gln Cys Thr Gly Asp Gly Gly Arg Thr Glu Thr Arg Asn 
                245                 250                 255     


Thr Thr Asp Thr Arg Val Thr Val Asp Gly Leu Gly Pro Gly Ser Leu 
            260                 265                 270         


Tyr Thr Cys Ser Val Trp Val Glu Lys Asp Gly Val Asn Ser Ser Val 
        275                 280                 285             


Glu Ile Val Thr Ser Ala Thr Ala Pro Asn Pro Val Arg Asn Leu Thr 
    290                 295                 300                 


Val Glu Ala Gln Thr Asn Ser Ser Ile Ala Leu Thr Trp Glu Val Pro 
305                 310                 315                 320 


Asp Gly Pro Asp Pro Gln Asn Ser Thr Tyr Gly Val Glu Tyr Thr Gly 
                325                 330                 335     


Asp Gly Gly Arg Ala Gly Thr Arg Ser Thr Ala His Thr Asn Ile Thr 
            340                 345                 350         


Val Asp Arg Leu Glu Pro Gly Cys Leu Tyr Val Phe Ser Val Trp Val 
        355                 360                 365             


Gly Lys Asn Gly Ile Asn Ser Ser Arg Glu Thr Arg Asn Ala Thr Thr 
    370                 375                 380                 


Ala Pro Asn Pro Val Arg Asn Leu His Met Glu Thr Gln Thr Asn Ser 
385                 390                 395                 400 


Ser Ile Ala Leu Cys Trp Glu Val Pro Asp Gly Pro Tyr Pro Gln Asp 
                405                 410                 415     


Tyr Thr Tyr Trp Val Glu Tyr Thr Gly Asp Gly Gly Gly Thr Glu Thr 
            420                 425                 430         


Arg Asn Thr Thr Asn Thr Ser Val Thr Ala Glu Arg Leu Glu Pro Gly 
        435                 440                 445             


Thr Leu Tyr Thr Phe Ser Val Trp Ala Glu Lys Asn Gly Ala Arg Gly 
    450                 455                 460                 


Ser Arg Gln Asn Val Ser Ile Ser Thr Val Pro Asn Ala Val Thr Ser 
465                 470                 475                 480 


Leu Ser Lys Gln Asp Trp Thr Asn Ser Thr Ile Ala Leu Arg Trp Thr 
                485                 490                 495     


Ala Pro Gln Gly Pro Gly Gln Ser Ser Tyr Ser Tyr Trp Val Ser Trp 
            500                 505                 510         


Val Arg Glu Gly Met Thr Asp Pro Arg Thr Gln Ser Thr Ser Gly Thr 
        515                 520                 525             


Asp Ile Thr Leu Lys Glu Leu Glu Ala Gly Ser Leu Tyr His Leu Thr 
    530                 535                 540                 


Val Trp Ala Glu Arg Asn Glu Val Arg Gly Tyr Asn Ser Thr Leu Thr 
545                 550                 555                 560 


Ala Ala Thr Ala Pro Asn Glu Val Thr Asp Leu Gln Asn Glu Thr Gln 
                565                 570                 575     


Thr Lys Asn Ser Val Met Leu Trp Trp Lys Ala Pro Gly Asp Pro His 
            580                 585                 590         


Ser Gln Leu Tyr Val Tyr Trp Val Gln Trp Ala Ser Lys Gly His Pro 
        595                 600                 605             


Arg Arg Gly Gln Asp Pro Gln Ala Asn Trp Val Asn Gln Thr Ser Arg 
    610                 615                 620                 


Thr Asn Glu Thr Trp Tyr Lys Val Glu Ala Leu Glu Pro Gly Thr Leu 
625                 630                 635                 640 


Tyr Asn Phe Thr Val Trp Ala Glu Arg Asn Asp Val Ala Ser Ser Thr 
                645                 650                 655     


Gln Ser Leu Cys Ala Ser Thr Tyr Pro Asp Thr Val Thr Ile Thr Ser 
            660                 665                 670         


Cys Val Ser Thr Ser Ala Gly Tyr Gly Val Asn Leu Ile Trp Ser Cys 
        675                 680                 685             


Pro Gln Gly Gly Tyr Glu Ala Phe Glu Leu Glu Val Gly Gly Gln Arg 
    690                 695                 700                 


Gly Ser Gln Asp Arg Ser Ser Cys Gly Glu Ala Val Ser Val Leu Gly 
705                 710                 715                 720 


Leu Gly Pro Ala Arg Ser Tyr Pro Ala Thr Ile Thr Thr Ile Trp Asp 
                725                 730                 735     


Gly Met Lys Val Val Ser His Ser Val Val Cys His Thr Glu Ser Ala 
            740                 745                 750         


Gly Val Ile Ala Gly Ala Phe Val Gly Ile Leu Leu Phe Leu Ile Leu 
        755                 760                 765             


Val Gly Leu Leu Ile Phe Phe Leu Lys Arg Arg Asn Lys Lys Lys Gln 
    770                 775                 780                 


Gln Lys Pro Glu Leu Arg Asp Leu Val Phe Ser Ser Pro Gly Asp Ile 
785                 790                 795                 800 


Pro Ala Glu Asp Phe Ala Asp His Val Arg Lys Asn Glu Arg Asp Ser 
                805                 810                 815     


Asn Cys Gly Phe Ala Asp Glu Tyr Gln Gln Leu Ser Leu Val Gly His 
            820                 825                 830         


Ser Gln Ser Gln Met Val Ala Ser Ala Ser Glu Asn Asn Ala Lys Asn 
        835                 840                 845             


Arg Tyr Arg Asn Val Leu Pro Tyr Asp Trp Ser Arg Val Pro Leu Lys 
    850                 855                 860                 


Pro Ile His Glu Glu Pro Gly Ser Asp Tyr Ile Asn Ala Ser Phe Met 
865                 870                 875                 880 


Pro Gly Leu Trp Ser Pro Gln Glu Phe Ile Ala Thr Gln Gly Pro Leu 
                885                 890                 895     


Pro Gln Thr Val Gly Asp Phe Trp Arg Leu Val Trp Glu Gln Gln Ser 
            900                 905                 910         


His Thr Leu Val Met Leu Thr Asn Cys Met Glu Ala Gly Arg Val Lys 
        915                 920                 925             


Cys Glu His Tyr Trp Pro Leu Asp Ser Gln Pro Cys Thr His Gly His 
    930                 935                 940                 


Leu Arg Val Thr Leu Val Gly Glu Glu Val Met Glu Asn Trp Thr Val 
945                 950                 955                 960 


Arg Glu Leu Leu Leu Leu Gln Val Glu Glu Gln Lys Thr Leu Ser Val 
                965                 970                 975     


Arg Gln Phe His Tyr Gln Ala Trp Pro Asp His Gly Val Pro Ser Ser 
            980                 985                 990         


Pro Asp Thr Leu Leu Ala Phe Trp  Arg Met Leu Arg Gln  Trp Leu Asp 
        995                 1000                 1005             


Gln Thr  Met Glu Gly Gly Pro  Pro Ile Val His Cys  Ser Ala Gly 
    1010                 1015                 1020             


Val Gly  Arg Thr Gly Thr Leu  Ile Ala Leu Asp Val  Leu Leu Arg 
    1025                 1030                 1035             


Gln Leu  Gln Ser Glu Gly Leu  Leu Gly Pro Phe Ser  Phe Val Arg 
    1040                 1045                 1050             


Lys Met  Arg Glu Ser Arg Pro  Leu Met Val Gln Thr  Glu Ala Gln 
    1055                 1060                 1065             


Tyr Val  Phe Leu His Gln Cys  Ile Leu Arg Phe Leu  Gln Gln Ser 
    1070                 1075                 1080             


Ala Gln  Ala Pro Ala Glu Lys  Glu Val Pro Tyr Glu  Asp Val Glu 
    1085                 1090                 1095             


Asn Leu  Ile Tyr Glu Asn Val  Ala Ala Ile Gln Ala  His Lys Leu 
    1100                 1105                 1110             


Glu Val  
    1115 


<210>  2720
<211>  1337
<212>  PRT
<213>  Homo sapiens

<400>  2720

Met Lys Pro Ala Ala Arg Glu Ala Arg Leu Pro Pro Arg Ser Pro Gly 
1               5                   10                  15      


Leu Arg Trp Ala Leu Pro Leu Leu Leu Leu Leu Leu Arg Leu Gly Gln 
            20                  25                  30          


Ile Leu Cys Ala Gly Gly Thr Pro Ser Pro Ile Pro Asp Pro Ser Val 
        35                  40                  45              


Ala Thr Val Ala Thr Gly Glu Asn Gly Ile Thr Gln Ile Ser Ser Thr 
    50                  55                  60                  


Ala Glu Ser Phe His Lys Gln Asn Gly Thr Gly Thr Pro Gln Val Glu 
65                  70                  75                  80  


Thr Asn Thr Ser Glu Asp Gly Glu Ser Ser Gly Ala Asn Asp Ser Leu 
                85                  90                  95      


Arg Thr Pro Glu Gln Gly Ser Asn Gly Thr Asp Gly Ala Ser Gln Lys 
            100                 105                 110         


Thr Pro Ser Ser Thr Gly Pro Ser Pro Val Phe Asp Ile Lys Ala Val 
        115                 120                 125             


Ser Ile Ser Pro Thr Asn Val Ile Leu Thr Trp Lys Ser Asn Asp Thr 
    130                 135                 140                 


Ala Ala Ser Glu Tyr Lys Tyr Val Val Lys His Lys Met Glu Asn Glu 
145                 150                 155                 160 


Lys Thr Ile Thr Val Val His Gln Pro Trp Cys Asn Ile Thr Gly Leu 
                165                 170                 175     


Arg Pro Ala Thr Ser Tyr Val Phe Ser Ile Thr Pro Gly Ile Gly Asn 
            180                 185                 190         


Glu Thr Trp Gly Asp Pro Arg Val Ile Lys Val Ile Thr Glu Pro Ile 
        195                 200                 205             


Pro Val Ser Asp Leu Arg Val Ala Leu Thr Gly Val Arg Lys Ala Ala 
    210                 215                 220                 


Leu Ser Trp Ser Asn Gly Asn Gly Thr Ala Ser Cys Arg Val Leu Leu 
225                 230                 235                 240 


Glu Ser Ile Gly Ser His Glu Glu Leu Thr Gln Asp Ser Arg Leu Gln 
                245                 250                 255     


Val Asn Ile Ser Gly Leu Lys Pro Gly Val Gln Tyr Asn Ile Asn Pro 
            260                 265                 270         


Tyr Leu Leu Gln Ser Asn Lys Thr Lys Gly Asp Pro Leu Gly Thr Glu 
        275                 280                 285             


Gly Gly Leu Asp Ala Ser Asn Thr Glu Arg Ser Arg Ala Gly Ser Pro 
    290                 295                 300                 


Thr Ala Pro Val His Asp Glu Ser Leu Val Gly Pro Val Asp Pro Ser 
305                 310                 315                 320 


Ser Gly Gln Gln Ser Arg Asp Thr Glu Val Leu Leu Val Gly Leu Glu 
                325                 330                 335     


Pro Gly Thr Arg Tyr Asn Ala Thr Val Tyr Ser Gln Ala Ala Asn Gly 
            340                 345                 350         


Thr Glu Gly Gln Pro Gln Ala Ile Glu Phe Arg Thr Asn Ala Ile Gln 
        355                 360                 365             


Val Phe Asp Val Thr Ala Val Asn Ile Ser Ala Thr Ser Leu Thr Leu 
    370                 375                 380                 


Ile Trp Lys Val Ser Asp Asn Glu Ser Ser Ser Asn Tyr Thr Tyr Lys 
385                 390                 395                 400 


Ile His Val Ala Gly Glu Thr Asp Ser Ser Asn Leu Asn Val Ser Glu 
                405                 410                 415     


Pro Arg Ala Val Ile Pro Gly Leu Arg Ser Ser Thr Phe Tyr Asn Ile 
            420                 425                 430         


Thr Val Cys Pro Val Leu Gly Asp Ile Glu Gly Thr Pro Gly Phe Leu 
        435                 440                 445             


Gln Val His Thr Pro Pro Val Pro Val Ser Asp Phe Arg Val Thr Val 
    450                 455                 460                 


Val Ser Thr Thr Glu Ile Gly Leu Ala Trp Ser Ser His Asp Ala Glu 
465                 470                 475                 480 


Ser Phe Gln Met His Ile Thr Gln Glu Gly Ala Gly Asn Ser Arg Val 
                485                 490                 495     


Glu Ile Thr Thr Asn Gln Ser Ile Ile Ile Gly Gly Leu Phe Pro Gly 
            500                 505                 510         


Thr Lys Tyr Cys Phe Glu Ile Val Pro Lys Gly Pro Asn Gly Thr Glu 
        515                 520                 525             


Gly Ala Ser Arg Thr Val Cys Asn Arg Thr Val Pro Ser Ala Val Phe 
    530                 535                 540                 


Asp Ile His Val Val Tyr Val Thr Thr Thr Glu Met Trp Leu Asp Trp 
545                 550                 555                 560 


Lys Ser Pro Asp Gly Ala Ser Glu Tyr Val Tyr His Leu Val Ile Glu 
                565                 570                 575     


Ser Lys His Gly Ser Asn His Thr Ser Thr Tyr Asp Lys Ala Ile Thr 
            580                 585                 590         


Leu Gln Gly Leu Ile Pro Gly Thr Leu Tyr Asn Ile Thr Ile Ser Pro 
        595                 600                 605             


Glu Val Asp His Val Trp Gly Asp Pro Asn Ser Thr Ala Gln Tyr Thr 
    610                 615                 620                 


Arg Pro Ser Asn Val Ser Asn Ile Asp Val Ser Thr Asn Thr Thr Ala 
625                 630                 635                 640 


Ala Thr Leu Ser Trp Gln Asn Phe Asp Asp Ala Ser Pro Thr Tyr Ser 
                645                 650                 655     


Tyr Cys Leu Leu Ile Glu Lys Ala Gly Asn Ser Ser Asn Ala Thr Gln 
            660                 665                 670         


Val Val Thr Asp Ile Gly Ile Thr Asp Ala Thr Val Thr Glu Leu Ile 
        675                 680                 685             


Pro Gly Ser Ser Tyr Thr Val Glu Ile Phe Ala Gln Val Gly Asp Gly 
    690                 695                 700                 


Ile Lys Ser Leu Glu Pro Gly Arg Lys Ser Phe Cys Thr Asp Pro Ala 
705                 710                 715                 720 


Ser Met Ala Ser Phe Asp Cys Glu Val Val Pro Lys Glu Pro Ala Leu 
                725                 730                 735     


Val Leu Lys Trp Thr Cys Pro Pro Gly Ala Asn Ala Gly Phe Glu Leu 
            740                 745                 750         


Glu Val Ser Ser Gly Ala Trp Asn Asn Ala Thr His Leu Glu Ser Cys 
        755                 760                 765             


Ser Ser Glu Asn Gly Thr Glu Tyr Arg Thr Glu Val Thr Tyr Leu Asn 
    770                 775                 780                 


Phe Ser Thr Ser Tyr Asn Ile Ser Ile Thr Thr Val Ser Cys Gly Lys 
785                 790                 795                 800 


Met Ala Ala Pro Thr Arg Asn Thr Cys Thr Thr Gly Ile Thr Asp Pro 
                805                 810                 815     


Pro Pro Pro Asp Gly Ser Pro Asn Ile Thr Ser Val Ser His Asn Ser 
            820                 825                 830         


Val Lys Val Lys Phe Ser Gly Phe Glu Ala Ser His Gly Pro Ile Lys 
        835                 840                 845             


Ala Tyr Ala Val Ile Leu Thr Thr Gly Glu Ala Gly His Pro Ser Ala 
    850                 855                 860                 


Asp Val Leu Lys Tyr Thr Tyr Glu Asp Phe Lys Lys Gly Ala Ser Asp 
865                 870                 875                 880 


Thr Tyr Val Thr Tyr Leu Ile Arg Thr Glu Glu Lys Gly Arg Ser Gln 
                885                 890                 895     


Ser Leu Ser Glu Val Leu Lys Tyr Glu Ile Asp Val Gly Asn Glu Ser 
            900                 905                 910         


Thr Thr Leu Gly Tyr Tyr Asn Gly Lys Leu Glu Pro Leu Gly Ser Tyr 
        915                 920                 925             


Arg Ala Cys Val Ala Gly Phe Thr Asn Ile Thr Phe His Pro Gln Asn 
    930                 935                 940                 


Lys Gly Leu Ile Asp Gly Ala Glu Ser Tyr Val Ser Phe Ser Arg Tyr 
945                 950                 955                 960 


Ser Asp Ala Val Ser Leu Pro Gln Asp Pro Gly Val Ile Cys Gly Ala 
                965                 970                 975     


Val Phe Gly Cys Ile Phe Gly Ala Leu Val Ile Val Thr Val Gly Gly 
            980                 985                 990         


Phe Ile Phe Trp Arg Lys Lys Arg  Lys Asp Ala Lys Asn  Asn Glu Val 
        995                 1000                 1005             


Ser Phe  Ser Gln Ile Lys Pro  Lys Lys Ser Lys Leu  Ile Arg Val 
    1010                 1015                 1020             


Glu Asn  Phe Glu Ala Tyr Phe  Lys Lys Gln Gln Ala  Asp Ser Asn 
    1025                 1030                 1035             


Cys Gly  Phe Ala Glu Glu Tyr  Glu Asp Leu Lys Leu  Val Gly Ile 
    1040                 1045                 1050             


Ser Gln  Pro Lys Tyr Ala Ala  Glu Leu Ala Glu Asn  Arg Gly Lys 
    1055                 1060                 1065             


Asn Arg  Tyr Asn Asn Val Leu  Pro Tyr Asp Ile Ser  Arg Val Lys 
    1070                 1075                 1080             


Leu Ser  Val Gln Thr His Ser  Thr Asp Asp Tyr Ile  Asn Ala Asn 
    1085                 1090                 1095             


Tyr Met  Pro Gly Tyr His Ser  Lys Lys Asp Phe Ile  Ala Thr Gln 
    1100                 1105                 1110             


Gly Pro  Leu Pro Asn Thr Leu  Lys Asp Phe Trp Arg  Met Val Trp 
    1115                 1120                 1125             


Glu Lys  Asn Val Tyr Ala Ile  Ile Met Leu Thr Lys  Cys Val Glu 
    1130                 1135                 1140             


Gln Gly  Arg Thr Lys Cys Glu  Glu Tyr Trp Pro Ser  Lys Gln Ala 
    1145                 1150                 1155             


Gln Asp  Tyr Gly Asp Ile Thr  Val Ala Met Thr Ser  Glu Ile Val 
    1160                 1165                 1170             


Leu Pro  Glu Trp Thr Ile Arg  Asp Phe Thr Val Lys  Asn Ile Gln 
    1175                 1180                 1185             


Thr Ser  Glu Ser His Pro Leu  Arg Gln Phe His Phe  Thr Ser Trp 
    1190                 1195                 1200             


Pro Asp  His Gly Val Pro Asp  Thr Thr Asp Leu Leu  Ile Asn Phe 
    1205                 1210                 1215             


Arg Tyr  Leu Val Arg Asp Tyr  Met Lys Gln Ser Pro  Pro Glu Ser 
    1220                 1225                 1230             


Pro Ile  Leu Val His Cys Ser  Ala Gly Val Gly Arg  Thr Gly Thr 
    1235                 1240                 1245             


Phe Ile  Ala Ile Asp Arg Leu  Ile Tyr Gln Ile Glu  Asn Glu Asn 
    1250                 1255                 1260             


Thr Val  Asp Val Tyr Gly Ile  Val Tyr Asp Leu Arg  Met His Arg 
    1265                 1270                 1275             


Pro Leu  Met Val Gln Thr Glu  Asp Gln Tyr Val Phe  Leu Asn Gln 
    1280                 1285                 1290             


Cys Val  Leu Asp Ile Val Arg  Ser Gln Lys Asp Ser  Lys Val Asp 
    1295                 1300                 1305             


Leu Ile  Tyr Gln Asn Thr Thr  Ala Met Thr Ile Tyr  Glu Asn Leu 
    1310                 1315                 1320             


Ala Pro  Val Thr Thr Phe Gly  Lys Thr Asn Gly Tyr  Ile Ala 
    1325                 1330                 1335         


<210>  2721
<211>  1440
<212>  PRT
<213>  Homo sapiens

<400>  2721

Met Asp Thr Thr Ala Ala Ala Ala Leu Pro Ala Phe Val Ala Leu Leu 
1               5                   10                  15      


Leu Leu Ser Pro Trp Pro Leu Leu Gly Ser Ala Gln Gly Gln Phe Ser 
            20                  25                  30          


Ala Gly Gly Cys Thr Phe Asp Asp Gly Pro Gly Ala Cys Asp Tyr His 
        35                  40                  45              


Gln Asp Leu Tyr Asp Asp Phe Glu Trp Val His Val Ser Ala Gln Glu 
    50                  55                  60                  


Pro His Tyr Leu Pro Pro Glu Met Pro Gln Gly Ser Tyr Met Ile Val 
65                  70                  75                  80  


Asp Ser Ser Asp His Asp Pro Gly Glu Lys Ala Arg Leu Gln Leu Pro 
                85                  90                  95      


Thr Met Lys Glu Asn Asp Thr His Cys Ile Asp Phe Ser Tyr Leu Leu 
            100                 105                 110         


Tyr Ser Gln Lys Gly Leu Asn Pro Gly Thr Leu Asn Ile Leu Val Arg 
        115                 120                 125             


Val Asn Lys Gly Pro Leu Ala Asn Pro Ile Trp Asn Val Thr Gly Phe 
    130                 135                 140                 


Thr Gly Arg Asp Trp Leu Arg Ala Glu Leu Ala Val Ser Thr Phe Trp 
145                 150                 155                 160 


Pro Asn Glu Tyr Gln Val Ile Phe Glu Ala Glu Val Ser Gly Gly Arg 
                165                 170                 175     


Ser Gly Tyr Ile Ala Ile Asp Asp Ile Gln Val Leu Ser Tyr Pro Cys 
            180                 185                 190         


Asp Lys Ser Pro His Phe Leu Arg Leu Gly Asp Val Glu Val Asn Ala 
        195                 200                 205             


Gly Gln Asn Ala Thr Phe Gln Cys Ile Ala Thr Gly Arg Asp Ala Val 
    210                 215                 220                 


His Asn Lys Leu Trp Leu Gln Arg Arg Asn Gly Glu Asp Ile Pro Val 
225                 230                 235                 240 


Ala Gln Thr Lys Asn Ile Asn His Arg Arg Phe Ala Ala Ser Phe Arg 
                245                 250                 255     


Leu Gln Glu Val Thr Lys Thr Asp Gln Asp Leu Tyr Arg Cys Val Thr 
            260                 265                 270         


Gln Ser Glu Arg Gly Ser Gly Val Ser Asn Phe Ala Gln Leu Ile Val 
        275                 280                 285             


Arg Glu Pro Pro Arg Pro Ile Ala Pro Pro Gln Leu Leu Gly Val Gly 
    290                 295                 300                 


Pro Thr Tyr Leu Leu Ile Gln Leu Asn Ala Asn Ser Ile Ile Gly Asp 
305                 310                 315                 320 


Gly Pro Ile Ile Leu Lys Glu Val Glu Tyr Arg Met Thr Ser Gly Ser 
                325                 330                 335     


Trp Thr Glu Thr His Ala Val Asn Ala Pro Thr Tyr Lys Leu Trp His 
            340                 345                 350         


Leu Asp Pro Asp Thr Glu Tyr Glu Ile Arg Val Leu Leu Thr Arg Pro 
        355                 360                 365             


Gly Glu Gly Gly Thr Gly Leu Pro Gly Pro Pro Leu Ile Thr Arg Thr 
    370                 375                 380                 


Lys Cys Ala Glu Pro Met Arg Thr Pro Lys Thr Leu Lys Ile Ala Glu 
385                 390                 395                 400 


Ile Gln Ala Arg Arg Ile Ala Val Asp Trp Glu Ser Leu Gly Tyr Asn 
                405                 410                 415     


Ile Thr Arg Cys His Thr Phe Asn Val Thr Ile Cys Tyr His Tyr Phe 
            420                 425                 430         


Arg Gly His Asn Glu Ser Lys Ala Asp Cys Leu Asp Met Asp Pro Lys 
        435                 440                 445             


Ala Pro Gln His Val Val Asn His Leu Pro Pro Tyr Thr Asn Val Ser 
    450                 455                 460                 


Leu Lys Met Ile Leu Thr Asn Pro Glu Gly Arg Lys Glu Ser Glu Glu 
465                 470                 475                 480 


Thr Ile Ile Gln Thr Asp Glu Asp Val Pro Gly Pro Val Pro Val Lys 
                485                 490                 495     


Ser Leu Gln Gly Thr Ser Phe Glu Asn Lys Ile Phe Leu Asn Trp Lys 
            500                 505                 510         


Glu Pro Leu Asp Pro Asn Gly Ile Ile Thr Gln Tyr Glu Ile Ser Tyr 
        515                 520                 525             


Ser Ser Ile Arg Ser Phe Asp Pro Ala Val Pro Val Ala Gly Pro Pro 
    530                 535                 540                 


Gln Thr Val Ser Asn Leu Trp Asn Ser Thr His His Val Phe Met His 
545                 550                 555                 560 


Leu His Pro Gly Thr Thr Tyr Gln Phe Phe Ile Arg Ala Ser Thr Val 
                565                 570                 575     


Lys Gly Phe Gly Pro Ala Thr Ala Ile Asn Val Thr Thr Asn Ile Ser 
            580                 585                 590         


Ala Pro Thr Leu Pro Asp Tyr Glu Gly Val Asp Ala Ser Leu Asn Glu 
        595                 600                 605             


Thr Ala Thr Thr Ile Thr Val Leu Leu Arg Pro Ala Gln Ala Lys Gly 
    610                 615                 620                 


Ala Pro Ile Ser Ala Tyr Gln Ile Val Val Glu Glu Leu His Pro His 
625                 630                 635                 640 


Arg Thr Lys Arg Glu Ala Gly Ala Met Glu Cys Tyr Gln Val Pro Val 
                645                 650                 655     


Thr Tyr Gln Asn Ala Met Ser Gly Gly Ala Pro Tyr Tyr Phe Ala Ala 
            660                 665                 670         


Glu Leu Pro Pro Gly Asn Leu Pro Glu Pro Ala Pro Phe Thr Val Gly 
        675                 680                 685             


Asp Asn Arg Thr Tyr Gln Gly Phe Trp Asn Pro Pro Leu Ala Pro Arg 
    690                 695                 700                 


Lys Gly Tyr Asn Ile Tyr Phe Gln Ala Met Ser Ser Val Glu Lys Glu 
705                 710                 715                 720 


Thr Lys Thr Gln Cys Val Arg Ile Ala Thr Lys Ala Ala Ala Thr Glu 
                725                 730                 735     


Glu Pro Glu Val Ile Pro Asp Pro Ala Lys Gln Thr Asp Arg Val Val 
            740                 745                 750         


Lys Ile Ala Gly Ile Ser Ala Gly Ile Leu Val Phe Ile Leu Leu Leu 
        755                 760                 765             


Leu Val Val Ile Leu Ile Val Lys Lys Ser Lys Leu Ala Lys Lys Arg 
    770                 775                 780                 


Lys Asp Ala Met Gly Asn Thr Arg Gln Glu Met Thr His Met Val Asn 
785                 790                 795                 800 


Ala Met Asp Arg Ser Tyr Ala Asp Gln Ser Thr Leu His Ala Glu Asp 
                805                 810                 815     


Pro Leu Ser Ile Thr Phe Met Asp Gln His Asn Phe Ser Pro Arg Tyr 
            820                 825                 830         


Glu Asn His Ser Ala Thr Ala Glu Ser Ser Arg Leu Leu Asp Val Pro 
        835                 840                 845             


Arg Tyr Leu Cys Glu Gly Thr Glu Ser Pro Tyr Gln Thr Gly Gln Leu 
    850                 855                 860                 


His Pro Ala Ile Arg Val Ala Asp Leu Leu Gln His Ile Asn Leu Met 
865                 870                 875                 880 


Lys Thr Ser Asp Ser Tyr Gly Phe Lys Glu Glu Tyr Glu Ser Phe Phe 
                885                 890                 895     


Glu Gly Gln Ser Ala Ser Trp Asp Val Ala Lys Lys Asp Gln Asn Arg 
            900                 905                 910         


Ala Lys Asn Arg Tyr Gly Asn Ile Ile Ala Tyr Asp His Ser Arg Val 
        915                 920                 925             


Ile Leu Gln Pro Val Glu Asp Asp Pro Ser Ser Asp Tyr Ile Asn Ala 
    930                 935                 940                 


Asn Tyr Ile Asp Gly Tyr Gln Arg Pro Ser His Tyr Ile Ala Thr Gln 
945                 950                 955                 960 


Gly Pro Val His Glu Thr Val Tyr Asp Phe Trp Arg Met Ile Trp Gln 
                965                 970                 975     


Glu Gln Ser Ala Cys Ile Val Met Val Thr Asn Leu Val Glu Val Gly 
            980                 985                 990         


Arg Val Lys Cys Tyr Lys Tyr Trp  Pro Asp Asp Thr Glu  Val Tyr Gly 
        995                 1000                 1005             


Asp Phe  Lys Val Thr Cys Val  Glu Met Glu Pro Leu  Ala Glu Tyr 
    1010                 1015                 1020             


Val Val  Arg Thr Phe Thr Leu  Glu Arg Arg Gly Tyr  Asn Glu Ile 
    1025                 1030                 1035             


Arg Glu  Val Lys Gln Phe His  Phe Thr Gly Trp Pro  Asp His Gly 
    1040                 1045                 1050             


Val Pro  Tyr His Ala Thr Gly  Leu Leu Ser Phe Ile  Arg Arg Val 
    1055                 1060                 1065             


Lys Leu  Ser Asn Pro Pro Ser  Ala Gly Pro Ile Val  Val His Cys 
    1070                 1075                 1080             


Ser Ala  Gly Ala Gly Arg Thr  Gly Cys Tyr Ile Val  Ile Asp Ile 
    1085                 1090                 1095             


Met Leu  Asp Met Ala Glu Arg  Glu Gly Val Val Asp  Ile Tyr Asn 
    1100                 1105                 1110             


Cys Val  Lys Ala Leu Arg Ser  Arg Arg Ile Asn Met  Val Gln Thr 
    1115                 1120                 1125             


Glu Glu  Gln Tyr Ile Phe Ile  His Asp Ala Ile Leu  Glu Ala Cys 
    1130                 1135                 1140             


Leu Cys  Gly Glu Thr Ala Ile  Pro Val Cys Glu Phe  Lys Ala Ala 
    1145                 1150                 1155             


Tyr Phe  Asp Met Ile Arg Ile  Asp Ser Gln Thr Asn  Ser Ser His 
    1160                 1165                 1170             


Leu Lys  Asp Glu Phe Gln Thr  Leu Asn Ser Val Thr  Pro Arg Leu 
    1175                 1180                 1185             


Gln Ala  Glu Asp Cys Ser Ile  Ala Cys Leu Pro Arg  Asn His Asp 
    1190                 1195                 1200             


Lys Asn  Arg Phe Met Asp Met  Leu Pro Pro Asp Arg  Cys Leu Pro 
    1205                 1210                 1215             


Phe Leu  Ile Thr Ile Asp Gly  Glu Ser Ser Asn Tyr  Ile Asn Ala 
    1220                 1225                 1230             


Ala Leu  Met Asp Ser Tyr Arg  Gln Pro Ala Ala Phe  Ile Val Thr 
    1235                 1240                 1245             


Gln Tyr  Pro Leu Pro Asn Thr  Val Lys Asp Phe Trp  Arg Leu Val 
    1250                 1255                 1260             


Tyr Asp  Tyr Gly Cys Thr Ser  Ile Val Met Leu Asn  Glu Val Asp 
    1265                 1270                 1275             


Leu Ser  Gln Gly Cys Pro Gln  Tyr Trp Pro Glu Glu  Gly Met Leu 
    1280                 1285                 1290             


Arg Tyr  Gly Pro Ile Gln Val  Glu Cys Met Ser Cys  Ser Met Asp 
    1295                 1300                 1305             


Cys Asp  Val Ile Asn Arg Ile  Phe Arg Ile Cys Asn  Leu Thr Arg 
    1310                 1315                 1320             


Pro Gln  Glu Gly Tyr Leu Met  Val Gln Gln Phe Gln  Tyr Leu Gly 
    1325                 1330                 1335             


Trp Ala  Ser His Arg Glu Val  Pro Gly Ser Lys Arg  Ser Phe Leu 
    1340                 1345                 1350             


Lys Leu  Ile Leu Gln Val Glu  Lys Trp Gln Glu Glu  Cys Glu Glu 
    1355                 1360                 1365             


Gly Glu  Gly Arg Thr Ile Ile  His Cys Leu Asn Gly  Gly Gly Arg 
    1370                 1375                 1380             


Ser Gly  Met Phe Cys Ala Ile  Gly Ile Val Val Glu  Met Val Lys 
    1385                 1390                 1395             


Arg Gln  Asn Val Val Asp Val  Phe His Ala Val Lys  Thr Leu Arg 
    1400                 1405                 1410             


Asn Ser  Lys Pro Asn Met Val  Glu Ala Pro Glu Gln  Tyr Arg Phe 
    1415                 1420                 1425             


Cys Tyr  Asp Val Ala Leu Glu  Tyr Leu Glu Ser Ser  
    1430                 1435                 1440 


<210>  2722
<211>  1452
<212>  PRT
<213>  Homo sapiens

<400>  2722

Met Arg Gly Leu Gly Thr Cys Leu Ala Thr Leu Ala Gly Leu Leu Leu 
1               5                   10                  15      


Thr Ala Ala Gly Glu Thr Phe Ser Gly Gly Cys Leu Phe Asp Glu Pro 
            20                  25                  30          


Tyr Ser Thr Cys Gly Tyr Ser Gln Ser Glu Gly Asp Asp Phe Asn Trp 
        35                  40                  45              


Glu Gln Val Asn Thr Leu Thr Lys Pro Thr Ser Asp Pro Trp Met Pro 
    50                  55                  60                  


Ser Gly Ser Phe Met Leu Val Asn Ala Ser Gly Arg Pro Glu Gly Gln 
65                  70                  75                  80  


Arg Ala His Leu Leu Leu Pro Gln Leu Lys Glu Asn Asp Thr His Cys 
                85                  90                  95      


Ile Asp Phe His Tyr Phe Val Ser Ser Lys Ser Asn Ser Pro Pro Gly 
            100                 105                 110         


Leu Leu Asn Val Tyr Val Lys Val Asn Asn Gly Pro Leu Gly Asn Pro 
        115                 120                 125             


Ile Trp Asn Ile Ser Gly Asp Pro Thr Arg Thr Trp Asn Arg Ala Glu 
    130                 135                 140                 


Leu Ala Ile Ser Thr Phe Trp Pro Asn Phe Tyr Gln Val Ile Phe Glu 
145                 150                 155                 160 


Val Ile Thr Ser Gly His Gln Gly Tyr Leu Ala Ile Asp Glu Val Lys 
                165                 170                 175     


Val Leu Gly His Pro Cys Thr Arg Thr Pro His Phe Leu Arg Ile Gln 
            180                 185                 190         


Asn Val Glu Val Asn Ala Gly Gln Phe Ala Thr Phe Gln Cys Ser Ala 
        195                 200                 205             


Ile Gly Arg Thr Val Ala Gly Asp Arg Leu Trp Leu Gln Gly Ile Asp 
    210                 215                 220                 


Val Arg Asp Ala Pro Leu Lys Glu Ile Lys Val Thr Ser Ser Arg Arg 
225                 230                 235                 240 


Phe Ile Ala Ser Phe Asn Val Val Asn Thr Thr Lys Arg Asp Ala Gly 
                245                 250                 255     


Lys Tyr Arg Cys Met Ile Arg Thr Glu Gly Gly Val Gly Ile Ser Asn 
            260                 265                 270         


Tyr Ala Glu Leu Val Val Lys Glu Pro Pro Val Pro Ile Ala Pro Pro 
        275                 280                 285             


Gln Leu Ala Ser Val Gly Ala Thr Tyr Leu Trp Ile Gln Leu Asn Ala 
    290                 295                 300                 


Asn Ser Ile Asn Gly Asp Gly Pro Ile Val Ala Arg Glu Val Glu Tyr 
305                 310                 315                 320 


Cys Thr Ala Ser Gly Ser Trp Asn Asp Arg Gln Pro Val Asp Ser Thr 
                325                 330                 335     


Ser Tyr Lys Ile Gly His Leu Asp Pro Asp Thr Glu Tyr Glu Ile Ser 
            340                 345                 350         


Val Leu Leu Thr Arg Pro Gly Glu Gly Gly Thr Gly Ser Pro Gly Pro 
        355                 360                 365             


Ala Leu Arg Thr Arg Thr Lys Cys Ala Asp Pro Met Arg Gly Pro Arg 
    370                 375                 380                 


Lys Leu Glu Val Val Glu Val Lys Ser Arg Gln Ile Thr Ile Arg Trp 
385                 390                 395                 400 


Glu Pro Phe Gly Tyr Asn Val Thr Arg Cys His Ser Tyr Asn Leu Thr 
                405                 410                 415     


Val His Tyr Cys Tyr Gln Val Gly Gly Gln Glu Gln Val Arg Glu Glu 
            420                 425                 430         


Val Ser Trp Asp Thr Glu Asn Ser His Pro Gln His Thr Ile Thr Asn 
        435                 440                 445             


Leu Ser Pro Tyr Thr Asn Val Ser Val Lys Leu Ile Leu Met Asn Pro 
    450                 455                 460                 


Glu Gly Arg Lys Glu Ser Gln Glu Leu Ile Val Gln Thr Asp Glu Asp 
465                 470                 475                 480 


Leu Pro Gly Ala Val Pro Thr Glu Ser Ile Gln Gly Ser Thr Phe Glu 
                485                 490                 495     


Glu Lys Ile Phe Leu Gln Trp Arg Glu Pro Thr Gln Thr Tyr Gly Val 
            500                 505                 510         


Ile Thr Leu Tyr Glu Ile Thr Tyr Lys Ala Val Ser Ser Phe Asp Pro 
        515                 520                 525             


Glu Ile Asp Leu Ser Asn Gln Ser Gly Arg Val Ser Lys Leu Gly Asn 
    530                 535                 540                 


Glu Thr His Phe Leu Phe Phe Gly Leu Tyr Pro Gly Thr Thr Tyr Ser 
545                 550                 555                 560 


Phe Thr Ile Arg Ala Ser Thr Ala Lys Gly Phe Gly Pro Pro Ala Thr 
                565                 570                 575     


Asn Gln Phe Thr Thr Lys Ile Ser Ala Pro Ser Met Pro Ala Tyr Glu 
            580                 585                 590         


Leu Glu Thr Pro Leu Asn Gln Thr Asp Asn Thr Val Thr Val Met Leu 
        595                 600                 605             


Lys Pro Ala His Ser Arg Gly Ala Pro Val Ser Val Tyr Gln Ile Val 
    610                 615                 620                 


Val Glu Glu Glu Arg Pro Arg Arg Thr Lys Lys Thr Thr Glu Ile Leu 
625                 630                 635                 640 


Lys Cys Tyr Pro Val Pro Ile His Phe Gln Asn Ala Ser Leu Leu Asn 
                645                 650                 655     


Ser Gln Tyr Tyr Phe Ala Ala Glu Phe Pro Ala Asp Ser Leu Gln Ala 
            660                 665                 670         


Ala Gln Pro Phe Thr Ile Gly Asp Asn Lys Thr Tyr Asn Gly Tyr Trp 
        675                 680                 685             


Asn Thr Pro Leu Leu Pro Tyr Lys Ser Tyr Arg Ile Tyr Phe Gln Ala 
    690                 695                 700                 


Ala Ser Arg Ala Asn Gly Glu Thr Lys Ile Asp Cys Val Gln Val Ala 
705                 710                 715                 720 


Thr Lys Gly Ala Ala Thr Pro Lys Pro Val Pro Glu Pro Glu Lys Gln 
                725                 730                 735     


Thr Asp His Thr Val Lys Ile Ala Gly Val Ile Ala Gly Ile Leu Leu 
            740                 745                 750         


Phe Val Ile Ile Phe Leu Gly Val Val Leu Val Met Lys Lys Arg Lys 
        755                 760                 765             


Leu Ala Lys Lys Arg Lys Glu Thr Met Ser Ser Thr Arg Gln Glu Met 
    770                 775                 780                 


Thr Val Met Val Asn Ser Met Asp Lys Ser Tyr Ala Glu Gln Gly Thr 
785                 790                 795                 800 


Asn Cys Asp Glu Ala Phe Ser Phe Met Asp Thr His Asn Leu Asn Gly 
                805                 810                 815     


Arg Ser Val Ser Ser Pro Ser Ser Phe Thr Met Lys Thr Asn Thr Leu 
            820                 825                 830         


Ser Thr Ser Val Pro Asn Ser Tyr Tyr Pro Asp Glu Thr His Thr Met 
        835                 840                 845             


Ala Ser Asp Thr Ser Ser Leu Val Gln Ser His Thr Tyr Lys Lys Arg 
    850                 855                 860                 


Glu Pro Ala Asp Val Pro Tyr Gln Thr Gly Gln Leu His Pro Ala Ile 
865                 870                 875                 880 


Arg Val Ala Asp Leu Leu Gln His Ile Thr Gln Met Lys Cys Ala Glu 
                885                 890                 895     


Gly Tyr Gly Phe Lys Glu Glu Tyr Glu Ser Phe Phe Glu Gly Gln Ser 
            900                 905                 910         


Ala Pro Trp Asp Ser Ala Lys Lys Asp Glu Asn Arg Met Lys Asn Arg 
        915                 920                 925             


Tyr Gly Asn Ile Ile Ala Tyr Asp His Ser Arg Val Arg Leu Gln Thr 
    930                 935                 940                 


Ile Glu Gly Asp Thr Asn Ser Asp Tyr Ile Asn Gly Asn Tyr Ile Asp 
945                 950                 955                 960 


Gly Tyr His Arg Pro Asn His Tyr Ile Ala Thr Gln Gly Pro Met Gln 
                965                 970                 975     


Glu Thr Ile Tyr Asp Phe Trp Arg Met Val Trp His Glu Asn Thr Ala 
            980                 985                 990         


Ser Ile Ile Met Val Thr Asn Leu  Val Glu Val Gly Arg  Val Lys Cys 
        995                 1000                 1005             


Cys Lys  Tyr Trp Pro Asp Asp  Thr Glu Ile Tyr Lys  Asp Ile Lys 
    1010                 1015                 1020             


Val Thr  Leu Ile Glu Thr Glu  Leu Leu Ala Glu Tyr  Val Ile Arg 
    1025                 1030                 1035             


Thr Phe  Ala Val Glu Lys Arg  Gly Val His Glu Ile  Arg Glu Ile 
    1040                 1045                 1050             


Arg Gln  Phe His Phe Thr Gly  Trp Pro Asp His Gly  Val Pro Tyr 
    1055                 1060                 1065             


His Ala  Thr Gly Leu Leu Gly  Phe Val Arg Gln Val  Lys Ser Lys 
    1070                 1075                 1080             


Ser Pro  Pro Ser Ala Gly Pro  Leu Val Val His Cys  Ser Ala Gly 
    1085                 1090                 1095             


Ala Gly  Arg Thr Gly Cys Phe  Ile Val Ile Asp Ile  Met Leu Asp 
    1100                 1105                 1110             


Met Ala  Glu Arg Glu Gly Val  Val Asp Ile Tyr Asn  Cys Val Arg 
    1115                 1120                 1125             


Glu Leu  Arg Ser Arg Arg Val  Asn Met Val Gln Thr  Glu Glu Gln 
    1130                 1135                 1140             


Tyr Val  Phe Ile His Asp Ala  Ile Leu Glu Ala Cys  Leu Cys Gly 
    1145                 1150                 1155             


Asp Thr  Ser Val Pro Ala Ser  Gln Val Arg Ser Leu  Tyr Tyr Asp 
    1160                 1165                 1170             


Met Asn  Lys Leu Asp Pro Gln  Thr Asn Ser Ser Gln  Ile Lys Glu 
    1175                 1180                 1185             


Glu Phe  Arg Thr Leu Asn Met  Val Thr Pro Thr Leu  Arg Val Glu 
    1190                 1195                 1200             


Asp Cys  Ser Ile Ala Leu Leu  Pro Arg Asn His Glu  Lys Asn Arg 
    1205                 1210                 1215             


Cys Met  Asp Ile Leu Pro Pro  Asp Arg Cys Leu Pro  Phe Leu Ile 
    1220                 1225                 1230             


Thr Ile  Asp Gly Glu Ser Ser  Asn Tyr Ile Asn Ala  Ala Leu Met 
    1235                 1240                 1245             


Asp Ser  Tyr Lys Gln Pro Ser  Ala Phe Ile Val Thr  Gln His Pro 
    1250                 1255                 1260             


Leu Pro  Asn Thr Val Lys Asp  Phe Trp Arg Leu Val  Leu Asp Tyr 
    1265                 1270                 1275             


His Cys  Thr Ser Val Val Met  Leu Asn Asp Val Asp  Pro Ala Gln 
    1280                 1285                 1290             


Leu Cys  Pro Gln Tyr Trp Pro  Glu Asn Gly Val His  Arg His Gly 
    1295                 1300                 1305             


Pro Ile  Gln Val Glu Phe Val  Ser Ala Asp Leu Glu  Glu Asp Ile 
    1310                 1315                 1320             


Ile Ser  Arg Ile Phe Arg Ile  Tyr Asn Ala Ala Arg  Pro Gln Asp 
    1325                 1330                 1335             


Gly Tyr  Arg Met Val Gln Gln  Phe Gln Phe Leu Gly  Trp Pro Met 
    1340                 1345                 1350             


Tyr Arg  Asp Thr Pro Val Ser  Lys Arg Ser Phe Leu  Lys Leu Ile 
    1355                 1360                 1365             


Arg Gln  Val Asp Lys Trp Gln  Glu Glu Tyr Asn Gly  Gly Glu Gly 
    1370                 1375                 1380             


Arg Thr  Val Val His Cys Leu  Asn Gly Gly Gly Arg  Ser Gly Thr 
    1385                 1390                 1395             


Phe Cys  Ala Ile Ser Ile Val  Cys Glu Met Leu Arg  His Gln Arg 
    1400                 1405                 1410             


Thr Val  Asp Val Phe His Ala  Val Lys Thr Leu Arg  Asn Asn Lys 
    1415                 1420                 1425             


Pro Asn  Met Val Asp Leu Leu  Asp Gln Tyr Lys Phe  Cys Tyr Glu 
    1430                 1435                 1440             


Val Ala  Leu Glu Tyr Leu Asn  Ser Gly 
    1445                 1450         


<210>  2723
<211>  1188
<212>  PRT
<213>  Homo sapiens

<400>  2723

Met Gly His Leu Pro Thr Gly Ile His Gly Ala Arg Arg Leu Leu Pro 
1               5                   10                  15      


Leu Leu Trp Leu Phe Val Leu Phe Lys Asn Ala Thr Ala Phe His Val 
            20                  25                  30          


Thr Val Gln Asp Asp Asn Asn Ile Val Val Ser Leu Glu Ala Ser Asp 
        35                  40                  45              


Val Ile Ser Pro Ala Ser Val Tyr Val Val Lys Ile Thr Gly Glu Ser 
    50                  55                  60                  


Lys Asn Tyr Phe Phe Glu Phe Glu Glu Phe Asn Ser Thr Leu Pro Pro 
65                  70                  75                  80  


Pro Val Ile Phe Lys Ala Ser Tyr His Gly Leu Tyr Tyr Ile Ile Thr 
                85                  90                  95      


Leu Val Val Val Asn Gly Asn Val Val Thr Lys Pro Ser Arg Ser Ile 
            100                 105                 110         


Thr Val Leu Thr Lys Pro Leu Pro Val Thr Ser Val Ser Ile Tyr Asp 
        115                 120                 125             


Tyr Lys Pro Ser Pro Glu Thr Gly Val Leu Phe Glu Ile His Tyr Pro 
    130                 135                 140                 


Glu Lys Tyr Asn Val Phe Thr Arg Val Asn Ile Ser Tyr Trp Glu Gly 
145                 150                 155                 160 


Lys Asp Phe Arg Thr Met Leu Tyr Lys Asp Phe Phe Lys Gly Lys Thr 
                165                 170                 175     


Val Phe Asn His Trp Leu Pro Gly Met Cys Tyr Ser Asn Ile Thr Phe 
            180                 185                 190         


Gln Leu Val Ser Glu Ala Thr Phe Asn Lys Ser Thr Leu Val Glu Tyr 
        195                 200                 205             


Ser Gly Val Ser His Glu Pro Lys Gln His Arg Thr Ala Pro Tyr Pro 
    210                 215                 220                 


Pro Gln Asn Ile Ser Val Arg Ile Val Asn Leu Asn Lys Asn Asn Trp 
225                 230                 235                 240 


Glu Glu Gln Ser Gly Asn Phe Pro Glu Glu Ser Phe Met Arg Ser Gln 
                245                 250                 255     


Asp Thr Ile Gly Lys Glu Lys Leu Phe His Phe Thr Glu Glu Thr Pro 
            260                 265                 270         


Glu Ile Pro Ser Gly Asn Ile Ser Ser Gly Trp Pro Asp Phe Asn Ser 
        275                 280                 285             


Ser Asp Tyr Glu Thr Thr Ser Gln Pro Tyr Trp Trp Asp Ser Ala Ser 
    290                 295                 300                 


Ala Ala Pro Glu Ser Glu Asp Glu Phe Val Ser Val Leu Pro Met Glu 
305                 310                 315                 320 


Tyr Glu Asn Asn Ser Thr Leu Ser Glu Thr Glu Lys Ser Thr Ser Gly 
                325                 330                 335     


Ser Phe Ser Phe Phe Pro Val Gln Met Ile Leu Thr Trp Leu Pro Pro 
            340                 345                 350         


Lys Pro Pro Thr Ala Phe Asp Gly Phe His Ile His Ile Glu Arg Glu 
        355                 360                 365             


Glu Asn Phe Thr Glu Tyr Leu Met Val Asp Glu Glu Ala His Glu Phe 
    370                 375                 380                 


Val Ala Glu Leu Lys Glu Pro Gly Lys Tyr Lys Leu Ser Val Thr Thr 
385                 390                 395                 400 


Phe Ser Ser Ser Gly Ser Cys Glu Thr Arg Lys Ser Gln Ser Ala Lys 
                405                 410                 415     


Ser Leu Ser Phe Tyr Ile Ser Pro Ser Gly Glu Trp Ile Glu Glu Leu 
            420                 425                 430         


Thr Glu Lys Pro Gln His Val Ser Val His Val Leu Ser Ser Thr Thr 
        435                 440                 445             


Ala Leu Met Ser Trp Thr Ser Ser Gln Glu Asn Tyr Asn Ser Thr Ile 
    450                 455                 460                 


Val Ser Val Val Ser Leu Thr Cys Gln Lys Gln Lys Glu Ser Gln Arg 
465                 470                 475                 480 


Leu Glu Lys Gln Tyr Cys Thr Gln Val Asn Ser Ser Lys Pro Ile Ile 
                485                 490                 495     


Glu Asn Leu Val Pro Gly Ala Gln Tyr Gln Val Val Ile Tyr Leu Arg 
            500                 505                 510         


Lys Gly Pro Leu Ile Gly Pro Pro Ser Asp Pro Val Thr Phe Ala Ile 
        515                 520                 525             


Val Pro Thr Gly Ile Lys Asp Leu Met Leu Tyr Pro Leu Gly Pro Thr 
    530                 535                 540                 


Ala Val Val Leu Ser Trp Thr Arg Pro Tyr Leu Gly Val Phe Arg Lys 
545                 550                 555                 560 


Tyr Val Val Glu Met Phe Tyr Phe Asn Pro Ala Thr Met Thr Ser Glu 
                565                 570                 575     


Trp Thr Thr Tyr Tyr Glu Ile Ala Ala Thr Val Ser Leu Thr Ala Ser 
            580                 585                 590         


Val Arg Ile Ala Asn Leu Leu Pro Ala Trp Tyr Tyr Asn Phe Arg Val 
        595                 600                 605             


Thr Met Val Thr Trp Gly Asp Pro Glu Leu Ser Cys Cys Asp Ser Ser 
    610                 615                 620                 


Thr Ile Ser Phe Ile Thr Ala Pro Val Ala Pro Glu Ile Thr Ser Val 
625                 630                 635                 640 


Glu Tyr Phe Asn Ser Leu Leu Tyr Ile Ser Trp Thr Tyr Gly Asp Asp 
                645                 650                 655     


Thr Thr Asp Leu Ser His Ser Arg Met Leu His Trp Met Val Val Ala 
            660                 665                 670         


Glu Gly Lys Lys Lys Ile Lys Lys Ser Val Thr Arg Asn Val Met Thr 
        675                 680                 685             


Ala Ile Leu Ser Leu Pro Pro Gly Asp Ile Tyr Asn Leu Ser Val Thr 
    690                 695                 700                 


Ala Cys Thr Glu Arg Gly Ser Asn Thr Ser Met Leu Arg Leu Val Lys 
705                 710                 715                 720 


Leu Glu Pro Ala Pro Pro Lys Ser Leu Phe Ala Val Asn Lys Thr Gln 
                725                 730                 735     


Thr Ser Val Thr Leu Leu Trp Val Glu Glu Gly Val Ala Asp Phe Phe 
            740                 745                 750         


Glu Val Phe Cys Gln Gln Val Gly Ser Ser Gln Lys Thr Lys Leu Gln 
        755                 760                 765             


Glu Pro Val Ala Val Ser Ser His Val Val Thr Ile Ser Ser Leu Leu 
    770                 775                 780                 


Pro Ala Thr Ala Tyr Asn Cys Ser Val Thr Ser Phe Ser His Asp Ser 
785                 790                 795                 800 


Pro Ser Val Pro Thr Phe Ile Ala Val Ser Thr Met Val Thr Glu Met 
                805                 810                 815     


Asn Pro Asn Val Val Val Ile Ser Val Leu Ala Ile Leu Ser Thr Leu 
            820                 825                 830         


Leu Ile Gly Leu Leu Leu Val Thr Leu Ile Ile Leu Arg Lys Lys His 
        835                 840                 845             


Leu Gln Met Ala Arg Glu Cys Gly Ala Gly Thr Phe Val Asn Phe Ala 
    850                 855                 860                 


Ser Leu Glu Arg Asp Gly Lys Leu Pro Tyr Asn Trp Ser Lys Asn Gly 
865                 870                 875                 880 


Leu Lys Lys Arg Lys Leu Thr Asn Pro Val Gln Leu Asp Asp Phe Asp 
                885                 890                 895     


Ala Tyr Ile Lys Asp Met Ala Lys Asp Ser Asp Tyr Lys Phe Ser Leu 
            900                 905                 910         


Gln Phe Glu Glu Leu Lys Leu Ile Gly Leu Asp Ile Pro His Phe Ala 
        915                 920                 925             


Ala Asp Leu Pro Leu Asn Arg Cys Lys Asn Arg Tyr Thr Asn Ile Leu 
    930                 935                 940                 


Pro Tyr Asp Phe Ser Arg Val Arg Leu Val Ser Met Asn Glu Glu Glu 
945                 950                 955                 960 


Gly Ala Asp Tyr Ile Asn Ala Asn Tyr Ile Pro Gly Tyr Asn Ser Pro 
                965                 970                 975     


Gln Glu Tyr Ile Ala Thr Gln Gly Pro Leu Pro Glu Thr Arg Asn Asp 
            980                 985                 990         


Phe Trp Lys Met Val Leu Gln Gln  Lys Ser Gln Ile Ile  Val Met Leu 
        995                 1000                 1005             


Thr Gln  Cys Asn Glu Lys Arg  Arg Val Lys Cys Asp  His Tyr Trp 
    1010                 1015                 1020             


Pro Phe  Thr Glu Glu Pro Ile  Ala Tyr Gly Asp Ile  Thr Val Glu 
    1025                 1030                 1035             


Met Ile  Ser Glu Glu Glu Gln  Asp Asp Trp Ala Cys  Arg His Phe 
    1040                 1045                 1050             


Arg Ile  Asn Tyr Ala Asp Glu  Met Gln Asp Val Met  His Phe Asn 
    1055                 1060                 1065             


Tyr Thr  Ala Trp Pro Asp His  Gly Val Pro Thr Ala  Asn Ala Ala 
    1070                 1075                 1080             


Glu Ser  Ile Leu Gln Phe Val  His Met Val Arg Gln  Gln Ala Thr 
    1085                 1090                 1095             


Lys Ser  Lys Gly Pro Met Ile  Ile His Cys Ser Ala  Gly Val Gly 
    1100                 1105                 1110             


Arg Thr  Gly Thr Phe Ile Ala  Leu Asp Arg Leu Leu  Gln His Ile 
    1115                 1120                 1125             


Arg Asp  His Glu Phe Val Asp  Ile Leu Gly Leu Val  Ser Glu Met 
    1130                 1135                 1140             


Arg Ser  Tyr Arg Met Ser Met  Val Gln Thr Glu Glu  Gln Tyr Ile 
    1145                 1150                 1155             


Phe Ile  His Gln Cys Val Gln  Leu Met Trp Met Lys  Lys Lys Gln 
    1160                 1165                 1170             


Gln Phe  Cys Ile Ser Asp Val  Ile Tyr Glu Asn Val  Ser Lys Ser 
    1175                 1180                 1185             


<210>  2724
<211>  657
<212>  PRT
<213>  Homo sapiens

<400>  2724

Met Arg Arg Ala Val Cys Phe Pro Ala Leu Cys Leu Leu Leu Asn Leu 
1               5                   10                  15      


His Ala Ala Gly Cys Phe Ser Gly Asn Asn Asp His Phe Leu Ala Ile 
            20                  25                  30          


Asn Gln Lys Lys Ser Gly Lys Pro Val Phe Ile Tyr Lys His Ser Gln 
        35                  40                  45              


Asp Ile Glu Lys Ser Leu Asp Ile Ala Pro Gln Lys Ile Tyr Arg His 
    50                  55                  60                  


Ser Tyr His Ser Ser Ser Glu Ala Gln Val Ser Lys Arg His Gln Ile 
65                  70                  75                  80  


Val Asn Ser Ala Phe Pro Arg Pro Ala Tyr Asp Pro Ser Leu Asn Leu 
                85                  90                  95      


Leu Ala Met Asp Gly Gln Asp Leu Glu Val Glu Asn Leu Pro Ile Pro 
            100                 105                 110         


Ala Ala Asn Val Ile Val Val Thr Leu Gln Met Asp Val Asn Lys Leu 
        115                 120                 125             


Asn Ile Thr Leu Leu Arg Ile Phe Arg Gln Gly Val Ala Ala Ala Leu 
    130                 135                 140                 


Gly Leu Leu Pro Gln Gln Val His Ile Asn Arg Leu Ile Gly Lys Lys 
145                 150                 155                 160 


Asn Ser Ile Glu Leu Phe Val Ser Pro Ile Asn Arg Lys Thr Gly Ile 
                165                 170                 175     


Ser Asp Ala Leu Pro Ser Glu Glu Val Leu Arg Ser Leu Asn Ile Asn 
            180                 185                 190         


Val Leu His Gln Ser Leu Ser Gln Phe Gly Ile Thr Glu Val Ser Pro 
        195                 200                 205             


Glu Lys Asn Val Leu Gln Gly Gln His Glu Ala Asp Lys Ile Trp Ser 
    210                 215                 220                 


Lys Glu Gly Phe Tyr Ala Val Val Ile Phe Leu Ser Ile Phe Val Ile 
225                 230                 235                 240 


Ile Val Thr Cys Leu Met Ile Leu Tyr Arg Leu Lys Glu Arg Phe Gln 
                245                 250                 255     


Leu Ser Leu Arg Gln Asp Lys Glu Lys Asn Gln Glu Ile His Leu Ser 
            260                 265                 270         


Pro Ile Thr Leu Gln Pro Ala Leu Ser Glu Ala Lys Thr Val His Ser 
        275                 280                 285             


Met Val Gln Pro Glu Gln Ala Pro Lys Val Leu Asn Val Val Val Asp 
    290                 295                 300                 


Pro Gln Gly Arg Gly Ala Pro Glu Ile Lys Ala Thr Thr Ala Thr Ser 
305                 310                 315                 320 


Val Cys Pro Ser Pro Phe Lys Met Lys Pro Ile Gly Leu Gln Glu Arg 
                325                 330                 335     


Arg Gly Ser Asn Val Ser Leu Thr Leu Asp Met Ser Ser Leu Gly Asn 
            340                 345                 350         


Ile Glu Pro Phe Val Ser Ile Pro Thr Pro Arg Glu Lys Val Ala Met 
        355                 360                 365             


Glu Tyr Leu Gln Ser Ala Ser Arg Ile Leu Thr Arg Ser Gln Leu Arg 
    370                 375                 380                 


Asp Val Val Ala Ser Ser His Leu Leu Gln Ser Glu Phe Met Glu Ile 
385                 390                 395                 400 


Pro Met Asn Phe Val Asp Pro Lys Glu Ile Asp Ile Pro Arg His Gly 
                405                 410                 415     


Thr Lys Asn Arg Tyr Lys Thr Ile Leu Pro Asn Pro Leu Ser Arg Val 
            420                 425                 430         


Cys Leu Arg Pro Lys Asn Val Thr Asp Ser Leu Ser Thr Tyr Ile Asn 
        435                 440                 445             


Ala Asn Tyr Ile Arg Gly Tyr Ser Gly Lys Glu Lys Ala Phe Ile Ala 
    450                 455                 460                 


Thr Gln Gly Pro Met Ile Asn Thr Val Asp Asp Phe Trp Gln Met Val 
465                 470                 475                 480 


Trp Gln Glu Asp Ser Pro Val Ile Val Met Ile Thr Lys Leu Lys Glu 
                485                 490                 495     


Lys Asn Glu Lys Cys Val Leu Tyr Trp Pro Glu Lys Arg Gly Ile Tyr 
            500                 505                 510         


Gly Lys Val Glu Val Leu Val Ile Ser Val Asn Glu Cys Asp Asn Tyr 
        515                 520                 525             


Thr Ile Arg Asn Leu Val Leu Lys Gln Gly Ser His Thr Gln His Val 
    530                 535                 540                 


Lys His Tyr Trp Tyr Thr Ser Trp Pro Asp His Lys Thr Pro Asp Ser 
545                 550                 555                 560 


Ala Gln Pro Leu Leu Gln Leu Met Leu Asp Val Glu Glu Asp Arg Leu 
                565                 570                 575     


Ala Ser Gln Gly Arg Gly Pro Val Val Val His Cys Ser Ala Gly Ile 
            580                 585                 590         


Gly Arg Thr Gly Cys Phe Ile Ala Thr Ser Ile Gly Cys Gln Gln Leu 
        595                 600                 605             


Lys Glu Glu Gly Val Val Asp Ala Leu Ser Ile Val Cys Gln Leu Arg 
    610                 615                 620                 


Met Asp Arg Gly Gly Met Val Gln Thr Ser Glu Gln Tyr Glu Phe Val 
625                 630                 635                 640 


His His Ala Leu Cys Leu Tyr Glu Ser Arg Leu Ser Ala Glu Thr Val 
                645                 650                 655     


Gln 
    


<210>  2725
<211>  1948
<212>  PRT
<213>  Homo sapiens

<400>  2725

Met Ala Pro Thr Trp Gly Pro Gly Met Val Ser Val Val Gly Pro Met 
1               5                   10                  15      


Gly Leu Leu Val Val Leu Leu Val Gly Gly Cys Ala Ala Glu Glu Pro 
            20                  25                  30          


Pro Arg Phe Ile Lys Glu Pro Lys Asp Gln Ile Gly Val Ser Gly Gly 
        35                  40                  45              


Val Ala Ser Phe Val Cys Gln Ala Thr Gly Asp Pro Lys Pro Arg Val 
    50                  55                  60                  


Thr Trp Asn Lys Lys Gly Lys Lys Val Asn Ser Gln Arg Phe Glu Thr 
65                  70                  75                  80  


Ile Glu Phe Asp Glu Ser Ala Gly Ala Val Leu Arg Ile Gln Pro Leu 
                85                  90                  95      


Arg Thr Pro Arg Asp Glu Asn Val Tyr Glu Cys Val Ala Gln Asn Ser 
            100                 105                 110         


Val Gly Glu Ile Thr Val His Ala Lys Leu Thr Val Leu Arg Glu Asp 
        115                 120                 125             


Gln Leu Pro Ser Gly Phe Pro Asn Ile Asp Met Gly Pro Gln Leu Lys 
    130                 135                 140                 


Val Val Glu Arg Thr Arg Thr Ala Thr Met Leu Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Asn Pro Asp Pro Glu Ile Thr Trp Phe Lys Asp Phe Leu Pro Val Asp 
                165                 170                 175     


Pro Ser Ala Ser Asn Gly Arg Ile Lys Gln Leu Arg Ser Glu Thr Phe 
            180                 185                 190         


Glu Ser Thr Pro Ile Arg Gly Ala Leu Gln Ile Glu Ser Ser Glu Glu 
        195                 200                 205             


Thr Asp Gln Gly Lys Tyr Glu Cys Val Ala Thr Asn Ser Ala Gly Val 
    210                 215                 220                 


Arg Tyr Ser Ser Pro Ala Asn Leu Tyr Val Arg Glu Leu Arg Glu Val 
225                 230                 235                 240 


Arg Arg Val Ala Pro Arg Phe Ser Ile Leu Pro Met Ser His Glu Ile 
                245                 250                 255     


Met Pro Gly Gly Asn Val Asn Ile Thr Cys Val Ala Val Gly Ser Pro 
            260                 265                 270         


Met Pro Tyr Val Lys Trp Met Gln Gly Ala Glu Asp Leu Thr Pro Glu 
        275                 280                 285             


Asp Asp Met Pro Val Gly Arg Asn Val Leu Glu Leu Thr Asp Val Lys 
    290                 295                 300                 


Asp Ser Ala Asn Tyr Thr Cys Val Ala Met Ser Ser Leu Gly Val Ile 
305                 310                 315                 320 


Glu Ala Val Ala Gln Ile Thr Val Lys Ser Leu Pro Lys Ala Pro Gly 
                325                 330                 335     


Thr Pro Met Val Thr Glu Asn Thr Ala Thr Ser Ile Thr Ile Thr Trp 
            340                 345                 350         


Asp Ser Gly Asn Pro Asp Pro Val Ser Tyr Tyr Val Ile Glu Tyr Lys 
        355                 360                 365             


Ser Lys Ser Gln Asp Gly Pro Tyr Gln Ile Lys Glu Asp Ile Thr Thr 
    370                 375                 380                 


Thr Arg Tyr Ser Ile Gly Gly Leu Ser Pro Asn Ser Glu Tyr Glu Ile 
385                 390                 395                 400 


Trp Val Ser Ala Val Asn Ser Ile Gly Gln Gly Pro Pro Ser Glu Ser 
                405                 410                 415     


Val Val Thr Arg Thr Gly Glu Gln Ala Pro Ala Ser Ala Pro Arg Asn 
            420                 425                 430         


Val Gln Ala Arg Met Leu Ser Ala Thr Thr Met Ile Val Gln Trp Glu 
        435                 440                 445             


Glu Pro Val Glu Pro Asn Gly Leu Ile Arg Gly Tyr Arg Val Tyr Tyr 
    450                 455                 460                 


Thr Met Glu Pro Glu His Pro Val Gly Asn Trp Gln Lys His Asn Val 
465                 470                 475                 480 


Asp Asp Ser Leu Leu Thr Thr Val Gly Ser Leu Leu Glu Asp Glu Thr 
                485                 490                 495     


Tyr Thr Val Arg Val Leu Ala Phe Thr Ser Val Gly Asp Gly Pro Leu 
            500                 505                 510         


Ser Asp Pro Ile Gln Val Lys Thr Gln Gln Gly Val Pro Gly Gln Pro 
        515                 520                 525             


Met Asn Leu Arg Ala Glu Ala Arg Ser Glu Thr Ser Ile Thr Leu Ser 
    530                 535                 540                 


Trp Ser Pro Pro Arg Gln Glu Ser Ile Ile Lys Tyr Glu Leu Leu Phe 
545                 550                 555                 560 


Arg Glu Gly Asp His Gly Arg Glu Val Gly Arg Thr Phe Asp Pro Thr 
                565                 570                 575     


Thr Ser Tyr Val Val Glu Asp Leu Lys Pro Asn Thr Glu Tyr Ala Phe 
            580                 585                 590         


Arg Leu Ala Ala Arg Ser Pro Gln Gly Leu Gly Ala Phe Thr Pro Val 
        595                 600                 605             


Val Arg Gln Arg Thr Leu Gln Ser Lys Pro Ser Ala Pro Pro Gln Asp 
    610                 615                 620                 


Val Lys Cys Val Ser Val Arg Ser Thr Ala Ile Leu Val Ser Trp Arg 
625                 630                 635                 640 


Pro Pro Pro Pro Glu Thr His Asn Gly Ala Leu Val Gly Tyr Ser Val 
                645                 650                 655     


Arg Tyr Arg Pro Leu Gly Ser Glu Asp Pro Glu Pro Lys Glu Val Asn 
            660                 665                 670         


Gly Ile Pro Pro Thr Thr Thr Gln Ile Leu Leu Glu Ala Leu Glu Lys 
        675                 680                 685             


Trp Thr Gln Tyr Arg Ile Thr Thr Val Ala His Thr Glu Val Gly Pro 
    690                 695                 700                 


Gly Pro Glu Ser Ser Pro Val Val Val Arg Thr Asp Glu Asp Val Pro 
705                 710                 715                 720 


Ser Ala Pro Pro Arg Lys Val Glu Ala Glu Ala Leu Asn Ala Thr Ala 
                725                 730                 735     


Ile Arg Val Leu Trp Arg Ser Pro Ala Pro Gly Arg Gln His Gly Gln 
            740                 745                 750         


Ile Arg Gly Tyr Gln Val His Tyr Val Arg Met Glu Gly Ala Glu Ala 
        755                 760                 765             


Arg Gly Pro Pro Arg Ile Lys Asp Val Met Leu Ala Asp Ala Gln Trp 
    770                 775                 780                 


Glu Thr Asp Asp Thr Ala Glu Tyr Glu Met Val Ile Thr Asn Leu Gln 
785                 790                 795                 800 


Pro Glu Thr Ala Tyr Ser Ile Thr Val Ala Ala Tyr Thr Met Lys Gly 
                805                 810                 815     


Asp Gly Ala Arg Ser Lys Pro Lys Val Val Val Thr Lys Gly Ala Val 
            820                 825                 830         


Leu Gly Arg Pro Thr Leu Ser Val Gln Gln Thr Pro Glu Gly Ser Leu 
        835                 840                 845             


Leu Ala Arg Trp Glu Pro Pro Ala Gly Thr Ala Glu Asp Gln Val Leu 
    850                 855                 860                 


Gly Tyr Arg Leu Gln Phe Gly Arg Glu Asp Ser Thr Pro Leu Ala Thr 
865                 870                 875                 880 


Leu Glu Phe Pro Pro Ser Glu Asp Arg Tyr Thr Ala Ser Gly Val His 
                885                 890                 895     


Lys Gly Ala Thr Tyr Val Phe Arg Leu Ala Ala Arg Ser Arg Gly Gly 
            900                 905                 910         


Leu Gly Glu Glu Ala Ala Glu Val Leu Ser Ile Pro Glu Asp Thr Pro 
        915                 920                 925             


Arg Gly His Pro Gln Ile Leu Glu Ala Ala Gly Asn Ala Ser Ala Gly 
    930                 935                 940                 


Thr Val Leu Leu Arg Trp Leu Pro Pro Val Pro Ala Glu Arg Asn Gly 
945                 950                 955                 960 


Ala Ile Val Lys Tyr Thr Val Ala Val Arg Glu Ala Gly Ala Leu Gly 
                965                 970                 975     


Pro Ala Arg Glu Thr Glu Leu Pro Ala Ala Ala Glu Pro Gly Ala Glu 
            980                 985                 990         


Asn Ala Leu Thr Leu Gln Gly Leu  Lys Pro Asp Thr Ala  Tyr Asp Leu 
        995                 1000                 1005             


Gln Val  Arg Ala His Thr Arg  Arg Gly Pro Gly Pro  Phe Ser Pro 
    1010                 1015                 1020             


Pro Val  Arg Tyr Arg Thr Phe  Leu Arg Asp Gln Val  Ser Pro Lys 
    1025                 1030                 1035             


Asn Phe  Lys Val Lys Met Ile  Met Lys Thr Ser Val  Leu Leu Ser 
    1040                 1045                 1050             


Trp Glu  Phe Pro Asp Asn Tyr  Asn Ser Pro Thr Pro  Tyr Lys Ile 
    1055                 1060                 1065             


Gln Tyr  Asn Gly Leu Thr Leu  Asp Val Asp Gly Arg  Thr Thr Lys 
    1070                 1075                 1080             


Lys Leu  Ile Thr His Leu Lys  Pro His Thr Phe Tyr  Asn Phe Val 
    1085                 1090                 1095             


Leu Thr  Asn Arg Gly Ser Ser  Leu Gly Gly Leu Gln  Gln Thr Val 
    1100                 1105                 1110             


Thr Ala  Trp Thr Ala Phe Asn  Leu Leu Asn Gly Lys  Pro Ser Val 
    1115                 1120                 1125             


Ala Pro  Lys Pro Asp Ala Asp  Gly Phe Ile Met Val  Tyr Leu Pro 
    1130                 1135                 1140             


Asp Gly  Gln Ser Pro Val Pro  Val Gln Ser Tyr Phe  Ile Val Met 
    1145                 1150                 1155             


Val Pro  Leu Arg Lys Ser Arg  Gly Gly Gln Phe Leu  Thr Pro Leu 
    1160                 1165                 1170             


Gly Ser  Pro Glu Asp Met Asp  Leu Glu Glu Leu Ile  Gln Asp Ile 
    1175                 1180                 1185             


Ser Arg  Leu Gln Arg Arg Ser  Leu Arg His Ser Arg  Gln Leu Glu 
    1190                 1195                 1200             


Val Pro  Arg Pro Tyr Ile Ala  Ala Arg Phe Ser Val  Leu Pro Pro 
    1205                 1210                 1215             


Thr Phe  His Pro Gly Asp Gln  Lys Gln Tyr Gly Gly  Phe Asp Asn 
    1220                 1225                 1230             


Arg Gly  Leu Glu Pro Gly His  Arg Tyr Val Leu Phe  Val Leu Ala 
    1235                 1240                 1245             


Val Leu  Gln Lys Ser Glu Pro  Thr Phe Ala Ala Ser  Pro Phe Ser 
    1250                 1255                 1260             


Asp Pro  Phe Gln Leu Asp Asn  Pro Asp Pro Gln Pro  Ile Val Asp 
    1265                 1270                 1275             


Gly Glu  Glu Gly Leu Ile Trp  Val Ile Gly Pro Val  Leu Ala Val 
    1280                 1285                 1290             


Val Phe  Ile Ile Cys Ile Val  Ile Ala Ile Leu Leu  Tyr Lys Asn 
    1295                 1300                 1305             


Lys Pro  Asp Ser Lys Arg Lys  Asp Ser Glu Pro Arg  Thr Lys Cys 
    1310                 1315                 1320             


Leu Leu  Asn Asn Ala Asp Leu  Ala Pro His His Pro  Lys Asp Pro 
    1325                 1330                 1335             


Val Glu  Met Arg Arg Ile Asn  Phe Gln Thr Pro Asp  Ser Gly Leu 
    1340                 1345                 1350             


Arg Ser  Pro Leu Arg Glu Pro  Gly Phe His Phe Glu  Ser Met Leu 
    1355                 1360                 1365             


Ser His  Pro Pro Ile Pro Ile  Ala Asp Met Ala Glu  His Thr Glu 
    1370                 1375                 1380             


Arg Leu  Lys Ala Asn Asp Ser  Leu Lys Leu Ser Gln  Glu Tyr Glu 
    1385                 1390                 1395             


Ser Ile  Asp Pro Gly Gln Gln  Phe Thr Trp Glu His  Ser Asn Leu 
    1400                 1405                 1410             


Glu Val  Asn Lys Pro Lys Asn  Arg Tyr Ala Asn Val  Ile Ala Tyr 
    1415                 1420                 1425             


Asp His  Ser Arg Val Ile Leu  Gln Pro Ile Glu Gly  Ile Met Gly 
    1430                 1435                 1440             


Ser Asp  Tyr Ile Asn Ala Asn  Tyr Val Asp Gly Tyr  Arg Cys Gln 
    1445                 1450                 1455             


Asn Ala  Tyr Ile Ala Thr Gln  Gly Pro Leu Pro Glu  Thr Phe Gly 
    1460                 1465                 1470             


Asp Phe  Trp Arg Met Val Trp  Glu Gln Arg Ser Ala  Thr Ile Val 
    1475                 1480                 1485             


Met Met  Thr Arg Leu Glu Glu  Lys Ser Arg Ile Lys  Cys Asp Gln 
    1490                 1495                 1500             


Tyr Trp  Pro Asn Arg Gly Thr  Glu Thr Tyr Gly Phe  Ile Gln Val 
    1505                 1510                 1515             


Thr Leu  Leu Asp Thr Ile Glu  Leu Ala Thr Phe Cys  Val Arg Thr 
    1520                 1525                 1530             


Phe Ser  Leu His Lys Asn Gly  Ser Ser Glu Lys Arg  Glu Val Arg 
    1535                 1540                 1545             


Gln Phe  Gln Phe Thr Ala Trp  Pro Asp His Gly Val  Pro Glu Tyr 
    1550                 1555                 1560             


Pro Thr  Pro Phe Leu Ala Phe  Leu Arg Arg Val Lys  Thr Cys Asn 
    1565                 1570                 1575             


Pro Pro  Asp Ala Gly Pro Ile  Val Val His Cys Ser  Ala Gly Val 
    1580                 1585                 1590             


Gly Arg  Thr Gly Cys Phe Ile  Val Ile Asp Ala Met  Leu Glu Arg 
    1595                 1600                 1605             


Ile Lys  Pro Glu Lys Thr Val  Asp Val Tyr Gly His  Val Thr Leu 
    1610                 1615                 1620             


Met Arg  Ser Gln Arg Asn Tyr  Met Val Gln Thr Glu  Asp Gln Tyr 
    1625                 1630                 1635             


Ser Phe  Ile His Glu Ala Leu  Leu Glu Ala Val Gly  Cys Gly Asn 
    1640                 1645                 1650             


Thr Glu  Val Pro Ala Arg Ser  Leu Tyr Ala Tyr Ile  Gln Lys Leu 
    1655                 1660                 1665             


Ala Gln  Val Glu Pro Gly Glu  His Val Thr Gly Met  Glu Leu Glu 
    1670                 1675                 1680             


Phe Lys  Arg Leu Ala Asn Ser  Lys Ala His Thr Ser  Arg Phe Ile 
    1685                 1690                 1695             


Ser Ala  Asn Leu Pro Cys Asn  Lys Phe Lys Asn Arg  Leu Val Asn 
    1700                 1705                 1710             


Ile Met  Pro Tyr Glu Ser Thr  Arg Val Cys Leu Gln  Pro Ile Arg 
    1715                 1720                 1725             


Gly Val  Glu Gly Ser Asp Tyr  Ile Asn Ala Ser Phe  Ile Asp Gly 
    1730                 1735                 1740             


Tyr Arg  Gln Gln Lys Ala Tyr  Ile Ala Thr Gln Gly  Pro Leu Ala 
    1745                 1750                 1755             


Glu Thr  Thr Glu Asp Phe Trp  Arg Met Leu Trp Glu  Asn Asn Ser 
    1760                 1765                 1770             


Thr Ile  Val Val Met Leu Thr  Lys Leu Arg Glu Met  Gly Arg Glu 
    1775                 1780                 1785             


Lys Cys  His Gln Tyr Trp Pro  Ala Glu Arg Ser Ala  Arg Tyr Gln 
    1790                 1795                 1800             


Tyr Phe  Val Val Asp Pro Met  Ala Glu Tyr Asn Met  Pro Gln Tyr 
    1805                 1810                 1815             


Ile Leu  Arg Glu Phe Lys Val  Thr Asp Ala Arg Asp  Gly Gln Ser 
    1820                 1825                 1830             


Arg Thr  Val Arg Gln Phe Gln  Phe Thr Asp Trp Pro  Glu Gln Gly 
    1835                 1840                 1845             


Val Pro  Lys Ser Gly Glu Gly  Phe Ile Asp Phe Ile  Gly Gln Val 
    1850                 1855                 1860             


His Lys  Thr Lys Glu Gln Phe  Gly Gln Asp Gly Pro  Ile Ser Val 
    1865                 1870                 1875             


His Cys  Ser Ala Gly Val Gly  Arg Thr Gly Val Phe  Ile Thr Leu 
    1880                 1885                 1890             


Ser Ile  Val Leu Glu Arg Met  Arg Tyr Glu Gly Val  Val Asp Ile 
    1895                 1900                 1905             


Phe Gln  Thr Val Lys Met Leu  Arg Thr Gln Arg Pro  Ala Met Val 
    1910                 1915                 1920             


Gln Thr  Glu Asp Glu Tyr Gln  Phe Cys Tyr Gln Ala  Ala Leu Glu 
    1925                 1930                 1935             


Tyr Leu  Gly Ser Phe Asp His  Tyr Ala Thr 
    1940                 1945             


<210>  2726
<211>  2315
<212>  PRT
<213>  Homo sapiens

<400>  2726

Met Arg Ile Leu Lys Arg Phe Leu Ala Cys Ile Gln Leu Leu Cys Val 
1               5                   10                  15      


Cys Arg Leu Asp Trp Ala Asn Gly Tyr Tyr Arg Gln Gln Arg Lys Leu 
            20                  25                  30          


Val Glu Glu Ile Gly Trp Ser Tyr Thr Gly Ala Leu Asn Gln Lys Asn 
        35                  40                  45              


Trp Gly Lys Lys Tyr Pro Thr Cys Asn Ser Pro Lys Gln Ser Pro Ile 
    50                  55                  60                  


Asn Ile Asp Glu Asp Leu Thr Gln Val Asn Val Asn Leu Lys Lys Leu 
65                  70                  75                  80  


Lys Phe Gln Gly Trp Asp Lys Thr Ser Leu Glu Asn Thr Phe Ile His 
                85                  90                  95      


Asn Thr Gly Lys Thr Val Glu Ile Asn Leu Thr Asn Asp Tyr Arg Val 
            100                 105                 110         


Ser Gly Gly Val Ser Glu Met Val Phe Lys Ala Ser Lys Ile Thr Phe 
        115                 120                 125             


His Trp Gly Lys Cys Asn Met Ser Ser Asp Gly Ser Glu His Ser Leu 
    130                 135                 140                 


Glu Gly Gln Lys Phe Pro Leu Glu Met Gln Ile Tyr Cys Phe Asp Ala 
145                 150                 155                 160 


Asp Arg Phe Ser Ser Phe Glu Glu Ala Val Lys Gly Lys Gly Lys Leu 
                165                 170                 175     


Arg Ala Leu Ser Ile Leu Phe Glu Val Gly Thr Glu Glu Asn Leu Asp 
            180                 185                 190         


Phe Lys Ala Ile Ile Asp Gly Val Glu Ser Val Ser Arg Phe Gly Lys 
        195                 200                 205             


Gln Ala Ala Leu Asp Pro Phe Ile Leu Leu Asn Leu Leu Pro Asn Ser 
    210                 215                 220                 


Thr Asp Lys Tyr Tyr Ile Tyr Asn Gly Ser Leu Thr Ser Pro Pro Cys 
225                 230                 235                 240 


Thr Asp Thr Val Asp Trp Ile Val Phe Lys Asp Thr Val Ser Ile Ser 
                245                 250                 255     


Glu Ser Gln Leu Ala Val Phe Cys Glu Val Leu Thr Met Gln Gln Ser 
            260                 265                 270         


Gly Tyr Val Met Leu Met Asp Tyr Leu Gln Asn Asn Phe Arg Glu Gln 
        275                 280                 285             


Gln Tyr Lys Phe Ser Arg Gln Val Phe Ser Ser Tyr Thr Gly Lys Glu 
    290                 295                 300                 


Glu Ile His Glu Ala Val Cys Ser Ser Glu Pro Glu Asn Val Gln Ala 
305                 310                 315                 320 


Asp Pro Glu Asn Tyr Thr Ser Leu Leu Val Thr Trp Glu Arg Pro Arg 
                325                 330                 335     


Val Val Tyr Asp Thr Met Ile Glu Lys Phe Ala Val Leu Tyr Gln Gln 
            340                 345                 350         


Leu Asp Gly Glu Asp Gln Thr Lys His Glu Phe Leu Thr Asp Gly Tyr 
        355                 360                 365             


Gln Asp Leu Gly Ala Ile Leu Asn Asn Leu Leu Pro Asn Met Ser Tyr 
    370                 375                 380                 


Val Leu Gln Ile Val Ala Ile Cys Thr Asn Gly Leu Tyr Gly Lys Tyr 
385                 390                 395                 400 


Ser Asp Gln Leu Ile Val Asp Met Pro Thr Asp Asn Pro Glu Leu Asp 
                405                 410                 415     


Leu Phe Pro Glu Leu Ile Gly Thr Glu Glu Ile Ile Lys Glu Glu Glu 
            420                 425                 430         


Glu Gly Lys Asp Ile Glu Glu Gly Ala Ile Val Asn Pro Gly Arg Asp 
        435                 440                 445             


Ser Ala Thr Asn Gln Ile Arg Lys Lys Glu Pro Gln Ile Ser Thr Thr 
    450                 455                 460                 


Thr His Tyr Asn Arg Ile Gly Thr Lys Tyr Asn Glu Ala Lys Thr Asn 
465                 470                 475                 480 


Arg Ser Pro Thr Arg Gly Ser Glu Phe Ser Gly Lys Gly Asp Val Pro 
                485                 490                 495     


Asn Thr Ser Leu Asn Ser Thr Ser Gln Pro Val Thr Lys Leu Ala Thr 
            500                 505                 510         


Glu Lys Asp Ile Ser Leu Thr Ser Gln Thr Val Thr Glu Leu Pro Pro 
        515                 520                 525             


His Thr Val Glu Gly Thr Ser Ala Ser Leu Asn Asp Gly Ser Lys Thr 
    530                 535                 540                 


Val Leu Arg Ser Pro His Met Asn Leu Ser Gly Thr Ala Glu Ser Leu 
545                 550                 555                 560 


Asn Thr Val Ser Ile Thr Glu Tyr Glu Glu Glu Ser Leu Leu Thr Ser 
                565                 570                 575     


Phe Lys Leu Asp Thr Gly Ala Glu Asp Ser Ser Gly Ser Ser Pro Ala 
            580                 585                 590         


Thr Ser Ala Ile Pro Phe Ile Ser Glu Asn Ile Ser Gln Gly Tyr Ile 
        595                 600                 605             


Phe Ser Ser Glu Asn Pro Glu Thr Ile Thr Tyr Asp Val Leu Ile Pro 
    610                 615                 620                 


Glu Ser Ala Arg Asn Ala Ser Glu Asp Ser Thr Ser Ser Gly Ser Glu 
625                 630                 635                 640 


Glu Ser Leu Lys Asp Pro Ser Met Glu Gly Asn Val Trp Phe Pro Ser 
                645                 650                 655     


Ser Thr Asp Ile Thr Ala Gln Pro Asp Val Gly Ser Gly Arg Glu Ser 
            660                 665                 670         


Phe Leu Gln Thr Asn Tyr Thr Glu Ile Arg Val Asp Glu Ser Glu Lys 
        675                 680                 685             


Thr Thr Lys Ser Phe Ser Ala Gly Pro Val Met Ser Gln Gly Pro Ser 
    690                 695                 700                 


Val Thr Asp Leu Glu Met Pro His Tyr Ser Thr Phe Ala Tyr Phe Pro 
705                 710                 715                 720 


Thr Glu Val Thr Pro His Ala Phe Thr Pro Ser Ser Arg Gln Gln Asp 
                725                 730                 735     


Leu Val Ser Thr Val Asn Val Val Tyr Ser Gln Thr Thr Gln Pro Val 
            740                 745                 750         


Tyr Asn Gly Glu Thr Pro Leu Gln Pro Ser Tyr Ser Ser Glu Val Phe 
        755                 760                 765             


Pro Leu Val Thr Pro Leu Leu Leu Asp Asn Gln Ile Leu Asn Thr Thr 
    770                 775                 780                 


Pro Ala Ala Ser Ser Ser Asp Ser Ala Leu His Ala Thr Pro Val Phe 
785                 790                 795                 800 


Pro Ser Val Asp Val Ser Phe Glu Ser Ile Leu Ser Ser Tyr Asp Gly 
                805                 810                 815     


Ala Pro Leu Leu Pro Phe Ser Ser Ala Ser Phe Ser Ser Glu Leu Phe 
            820                 825                 830         


Arg His Leu His Thr Val Ser Gln Ile Leu Pro Gln Val Thr Ser Ala 
        835                 840                 845             


Thr Glu Ser Asp Lys Val Pro Leu His Ala Ser Leu Pro Val Ala Gly 
    850                 855                 860                 


Gly Asp Leu Leu Leu Glu Pro Ser Leu Ala Gln Tyr Ser Asp Val Leu 
865                 870                 875                 880 


Ser Thr Thr His Ala Ala Ser Glu Thr Leu Glu Phe Gly Ser Glu Ser 
                885                 890                 895     


Gly Val Leu Tyr Lys Thr Leu Met Phe Ser Gln Val Glu Pro Pro Ser 
            900                 905                 910         


Ser Asp Ala Met Met His Ala Arg Ser Ser Gly Pro Glu Pro Ser Tyr 
        915                 920                 925             


Ala Leu Ser Asp Asn Glu Gly Ser Gln His Ile Phe Thr Val Ser Tyr 
    930                 935                 940                 


Ser Ser Ala Ile Pro Val His Asp Ser Val Gly Val Thr Tyr Gln Gly 
945                 950                 955                 960 


Ser Leu Phe Ser Gly Pro Ser His Ile Pro Ile Pro Lys Ser Ser Leu 
                965                 970                 975     


Ile Thr Pro Thr Ala Ser Leu Leu Gln Pro Thr His Ala Leu Ser Gly 
            980                 985                 990         


Asp Gly Glu Trp Ser Gly Ala Ser  Ser Asp Ser Glu Phe  Leu Leu Pro 
        995                 1000                 1005             


Asp Thr  Asp Gly Leu Thr Ala  Leu Asn Ile Ser Ser  Pro Val Ser 
    1010                 1015                 1020             


Val Ala  Glu Phe Thr Tyr Thr  Thr Ser Val Phe Gly  Asp Asp Asn 
    1025                 1030                 1035             


Lys Ala  Leu Ser Lys Ser Glu  Ile Ile Tyr Gly Asn  Glu Thr Glu 
    1040                 1045                 1050             


Leu Gln  Ile Pro Ser Phe Asn  Glu Met Val Tyr Pro  Ser Glu Ser 
    1055                 1060                 1065             


Thr Val  Met Pro Asn Met Tyr  Asp Asn Val Asn Lys  Leu Asn Ala 
    1070                 1075                 1080             


Ser Leu  Gln Glu Thr Ser Val  Ser Ile Ser Ser Thr  Lys Gly Met 
    1085                 1090                 1095             


Phe Pro  Gly Ser Leu Ala His  Thr Thr Thr Lys Val  Phe Asp His 
    1100                 1105                 1110             


Glu Ile  Ser Gln Val Pro Glu  Asn Asn Phe Ser Val  Gln Pro Thr 
    1115                 1120                 1125             


His Thr  Val Ser Gln Ala Ser  Gly Asp Thr Ser Leu  Lys Pro Val 
    1130                 1135                 1140             


Leu Ser  Ala Asn Ser Glu Pro  Ala Ser Ser Asp Pro  Ala Ser Ser 
    1145                 1150                 1155             


Glu Met  Leu Ser Pro Ser Thr  Gln Leu Leu Phe Tyr  Glu Thr Ser 
    1160                 1165                 1170             


Ala Ser  Phe Ser Thr Glu Val  Leu Leu Gln Pro Ser  Phe Gln Ala 
    1175                 1180                 1185             


Ser Asp  Val Asp Thr Leu Leu  Lys Thr Val Leu Pro  Ala Val Pro 
    1190                 1195                 1200             


Ser Asp  Pro Ile Leu Val Glu  Thr Pro Lys Val Asp  Lys Ile Ser 
    1205                 1210                 1215             


Ser Thr  Met Leu His Leu Ile  Val Ser Asn Ser Ala  Ser Ser Glu 
    1220                 1225                 1230             


Asn Met  Leu His Ser Thr Ser  Val Pro Val Phe Asp  Val Ser Pro 
    1235                 1240                 1245             


Thr Ser  His Met His Ser Ala  Ser Leu Gln Gly Leu  Thr Ile Ser 
    1250                 1255                 1260             


Tyr Ala  Ser Glu Lys Tyr Glu  Pro Val Leu Leu Lys  Ser Glu Ser 
    1265                 1270                 1275             


Ser His  Gln Val Val Pro Ser  Leu Tyr Ser Asn Asp  Glu Leu Phe 
    1280                 1285                 1290             


Gln Thr  Ala Asn Leu Glu Ile  Asn Gln Ala His Pro  Pro Lys Gly 
    1295                 1300                 1305             


Arg His  Val Phe Ala Thr Pro  Val Leu Ser Ile Asp  Glu Pro Leu 
    1310                 1315                 1320             


Asn Thr  Leu Ile Asn Lys Leu  Ile His Ser Asp Glu  Ile Leu Thr 
    1325                 1330                 1335             


Ser Thr  Lys Ser Ser Val Thr  Gly Lys Val Phe Ala  Gly Ile Pro 
    1340                 1345                 1350             


Thr Val  Ala Ser Asp Thr Phe  Val Ser Thr Asp His  Ser Val Pro 
    1355                 1360                 1365             


Ile Gly  Asn Gly His Val Ala  Ile Thr Ala Val Ser  Pro His Arg 
    1370                 1375                 1380             


Asp Gly  Ser Val Thr Ser Thr  Lys Leu Leu Phe Pro  Ser Lys Ala 
    1385                 1390                 1395             


Thr Ser  Glu Leu Ser His Ser  Ala Lys Ser Asp Ala  Gly Leu Val 
    1400                 1405                 1410             


Gly Gly  Gly Glu Asp Gly Asp  Thr Asp Asp Asp Gly  Asp Asp Asp 
    1415                 1420                 1425             


Asp Asp  Asp Arg Gly Ser Asp  Gly Leu Ser Ile His  Lys Cys Met 
    1430                 1435                 1440             


Ser Cys  Ser Ser Tyr Arg Glu  Ser Gln Glu Lys Val  Met Asn Asp 
    1445                 1450                 1455             


Ser Asp  Thr His Glu Asn Ser  Leu Met Asp Gln Asn  Asn Pro Ile 
    1460                 1465                 1470             


Ser Tyr  Ser Leu Ser Glu Asn  Ser Glu Glu Asp Asn  Arg Val Thr 
    1475                 1480                 1485             


Ser Val  Ser Ser Asp Ser Gln  Thr Gly Met Asp Arg  Ser Pro Gly 
    1490                 1495                 1500             


Lys Ser  Pro Ser Ala Asn Gly  Leu Ser Gln Lys His  Asn Asp Gly 
    1505                 1510                 1515             


Lys Glu  Glu Asn Asp Ile Gln  Thr Gly Ser Ala Leu  Leu Pro Leu 
    1520                 1525                 1530             


Ser Pro  Glu Ser Lys Ala Trp  Ala Val Leu Thr Ser  Asp Glu Glu 
    1535                 1540                 1545             


Ser Gly  Ser Gly Gln Gly Thr  Ser Asp Ser Leu Asn  Glu Asn Glu 
    1550                 1555                 1560             


Thr Ser  Thr Asp Phe Ser Phe  Ala Asp Thr Asn Glu  Lys Asp Ala 
    1565                 1570                 1575             


Asp Gly  Ile Leu Ala Ala Gly  Asp Ser Glu Ile Thr  Pro Gly Phe 
    1580                 1585                 1590             


Pro Gln  Ser Pro Thr Ser Ser  Val Thr Ser Glu Asn  Ser Glu Val 
    1595                 1600                 1605             


Phe His  Val Ser Glu Ala Glu  Ala Ser Asn Ser Ser  His Glu Ser 
    1610                 1615                 1620             


Arg Ile  Gly Leu Ala Glu Gly  Leu Glu Ser Glu Lys  Lys Ala Val 
    1625                 1630                 1635             


Ile Pro  Leu Val Ile Val Ser  Ala Leu Thr Phe Ile  Cys Leu Val 
    1640                 1645                 1650             


Val Leu  Val Gly Ile Leu Ile  Tyr Trp Arg Lys Cys  Phe Gln Thr 
    1655                 1660                 1665             


Ala His  Phe Tyr Leu Glu Asp  Ser Thr Ser Pro Arg  Val Ile Ser 
    1670                 1675                 1680             


Thr Pro  Pro Thr Pro Ile Phe  Pro Ile Ser Asp Asp  Val Gly Ala 
    1685                 1690                 1695             


Ile Pro  Ile Lys His Phe Pro  Lys His Val Ala Asp  Leu His Ala 
    1700                 1705                 1710             


Ser Ser  Gly Phe Thr Glu Glu  Phe Glu Thr Leu Lys  Glu Phe Tyr 
    1715                 1720                 1725             


Gln Glu  Val Gln Ser Cys Thr  Val Asp Leu Gly Ile  Thr Ala Asp 
    1730                 1735                 1740             


Ser Ser  Asn His Pro Asp Asn  Lys His Lys Asn Arg  Tyr Ile Asn 
    1745                 1750                 1755             


Ile Val  Ala Tyr Asp His Ser  Arg Val Lys Leu Ala  Gln Leu Ala 
    1760                 1765                 1770             


Glu Lys  Asp Gly Lys Leu Thr  Asp Tyr Ile Asn Ala  Asn Tyr Val 
    1775                 1780                 1785             


Asp Gly  Tyr Asn Arg Pro Lys  Ala Tyr Ile Ala Ala  Gln Gly Pro 
    1790                 1795                 1800             


Leu Lys  Ser Thr Ala Glu Asp  Phe Trp Arg Met Ile  Trp Glu His 
    1805                 1810                 1815             


Asn Val  Glu Val Ile Val Met  Ile Thr Asn Leu Val  Glu Lys Gly 
    1820                 1825                 1830             


Arg Arg  Lys Cys Asp Gln Tyr  Trp Pro Ala Asp Gly  Ser Glu Glu 
    1835                 1840                 1845             


Tyr Gly  Asn Phe Leu Val Thr  Gln Lys Ser Val Gln  Val Leu Ala 
    1850                 1855                 1860             


Tyr Tyr  Thr Val Arg Asn Phe  Thr Leu Arg Asn Thr  Lys Ile Lys 
    1865                 1870                 1875             


Lys Gly  Ser Gln Lys Gly Arg  Pro Ser Gly Arg Val  Val Thr Gln 
    1880                 1885                 1890             


Tyr His  Tyr Thr Gln Trp Pro  Asp Met Gly Val Pro  Glu Tyr Ser 
    1895                 1900                 1905             


Leu Pro  Val Leu Thr Phe Val  Arg Lys Ala Ala Tyr  Ala Lys Arg 
    1910                 1915                 1920             


His Ala  Val Gly Pro Val Val  Val His Cys Ser Ala  Gly Val Gly 
    1925                 1930                 1935             


Arg Thr  Gly Thr Tyr Ile Val  Leu Asp Ser Met Leu  Gln Gln Ile 
    1940                 1945                 1950             


Gln His  Glu Gly Thr Val Asn  Ile Phe Gly Phe Leu  Lys His Ile 
    1955                 1960                 1965             


Arg Ser  Gln Arg Asn Tyr Leu  Val Gln Thr Glu Glu  Gln Tyr Val 
    1970                 1975                 1980             


Phe Ile  His Asp Thr Leu Val  Glu Ala Ile Leu Ser  Lys Glu Thr 
    1985                 1990                 1995             


Glu Val  Leu Asp Ser His Ile  His Ala Tyr Val Asn  Ala Leu Leu 
    2000                 2005                 2010             


Ile Pro  Gly Pro Ala Gly Lys  Thr Lys Leu Glu Lys  Gln Phe Gln 
    2015                 2020                 2025             


Leu Leu  Ser Gln Ser Asn Ile  Gln Gln Ser Asp Tyr  Ser Ala Ala 
    2030                 2035                 2040             


Leu Lys  Gln Cys Asn Arg Glu  Lys Asn Arg Thr Ser  Ser Ile Ile 
    2045                 2050                 2055             


Pro Val  Glu Arg Ser Arg Val  Gly Ile Ser Ser Leu  Ser Gly Glu 
    2060                 2065                 2070             


Gly Thr  Asp Tyr Ile Asn Ala  Ser Tyr Ile Met Gly  Tyr Tyr Gln 
    2075                 2080                 2085             


Ser Asn  Glu Phe Ile Ile Thr  Gln His Pro Leu Leu  His Thr Ile 
    2090                 2095                 2100             


Lys Asp  Phe Trp Arg Met Ile  Trp Asp His Asn Ala  Gln Leu Val 
    2105                 2110                 2115             


Val Met  Ile Pro Asp Gly Gln  Asn Met Ala Glu Asp  Glu Phe Val 
    2120                 2125                 2130             


Tyr Trp  Pro Asn Lys Asp Glu  Pro Ile Asn Cys Glu  Ser Phe Lys 
    2135                 2140                 2145             


Val Thr  Leu Met Ala Glu Glu  His Lys Cys Leu Ser  Asn Glu Glu 
    2150                 2155                 2160             


Lys Leu  Ile Ile Gln Asp Phe  Ile Leu Glu Ala Thr  Gln Asp Asp 
    2165                 2170                 2175             


Tyr Val  Leu Glu Val Arg His  Phe Gln Cys Pro Lys  Trp Pro Asn 
    2180                 2185                 2190             


Pro Asp  Ser Pro Ile Ser Lys  Thr Phe Glu Leu Ile  Ser Val Ile 
    2195                 2200                 2205             


Lys Glu  Glu Ala Ala Asn Arg  Asp Gly Pro Met Ile  Val His Asp 
    2210                 2215                 2220             


Glu His  Gly Gly Val Thr Ala  Gly Thr Phe Cys Ala  Leu Thr Thr 
    2225                 2230                 2235             


Leu Met  His Gln Leu Glu Lys  Glu Asn Ser Val Asp  Val Tyr Gln 
    2240                 2245                 2250             


Val Ala  Lys Met Ile Asn Leu  Met Arg Pro Gly Val  Phe Ala Asp 
    2255                 2260                 2265             


Ile Glu  Gln Tyr Gln Phe Leu  Tyr Lys Val Ile Leu  Ser Leu Val 
    2270                 2275                 2280             


Ser Thr  Arg Gln Glu Glu Asn  Pro Ser Thr Ser Leu  Asp Ser Asn 
    2285                 2290                 2295             


Gly Ala  Ala Leu Pro Asp Gly  Asn Ile Ala Glu Ser  Leu Glu Ser 
    2300                 2305                 2310             


Leu Val  
    2315 


<210>  2727
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  2727

Met Ala Arg Met Gly Leu Ala Gly Ala Ala Gly Arg Trp Trp Gly Leu 
1               5                   10                  15      


Ala Leu Gly Leu Thr Ala Phe Phe Leu Pro Gly Val His Ser Gln Val 
            20                  25                  30          


Val Gln Val Asn Asp Ser Met Tyr Gly Phe Ile Gly Thr Asp Val Val 
        35                  40                  45              


Leu His Cys Ser Phe Ala Asn Pro Leu Pro Ser Val Lys Ile Thr Gln 
    50                  55                  60                  


Val Thr Trp Gln Lys Ser Thr Asn Gly Ser Lys Gln Asn Val Ala Ile 
65                  70                  75                  80  


Tyr Asn Pro Ser Met Gly Val Ser Val Leu Ala Pro Tyr Arg Glu Arg 
                85                  90                  95      


Val Glu Phe Leu Arg Pro Ser Phe Thr Asp Gly Thr Ile Arg Leu Ser 
            100                 105                 110         


Arg Leu Glu Leu Glu Asp Glu Gly Val Tyr Ile Cys Glu Phe Ala Thr 
        115                 120                 125             


Phe Pro Thr Gly Asn Arg Glu Ser Gln Leu Asn Leu Thr Val Met Ala 
    130                 135                 140                 


Lys Pro Thr Asn Trp Ile Glu Gly Thr Gln Ala Val Leu Arg Ala Lys 
145                 150                 155                 160 


Lys Gly Gln Asp Asp Lys Val Leu Val Ala Thr Cys Thr Ser Ala Asn 
                165                 170                 175     


Gly Lys Pro Pro Ser Val Val Ser Trp Glu Thr Arg Leu Lys Gly Glu 
            180                 185                 190         


Ala Glu Tyr Gln Glu Ile Arg Asn Pro Asn Gly Thr Val Thr Val Ile 
        195                 200                 205             


Ser Arg Tyr Arg Leu Val Pro Ser Arg Glu Ala His Gln Gln Ser Leu 
    210                 215                 220                 


Ala Cys Ile Val Asn Tyr His Met Asp Arg Phe Lys Glu Ser Leu Thr 
225                 230                 235                 240 


Leu Asn Val Gln Tyr Glu Pro Glu Val Thr Ile Glu Gly Phe Asp Gly 
                245                 250                 255     


Asn Trp Tyr Leu Gln Arg Met Asp Val Lys Leu Thr Cys Lys Ala Asp 
            260                 265                 270         


Ala Asn Pro Pro Ala Thr Glu Tyr His Trp Thr Thr Leu Asn Gly Ser 
        275                 280                 285             


Leu Pro Lys Gly Val Glu Ala Gln Asn Arg Thr Leu Phe Phe Lys Gly 
    290                 295                 300                 


Pro Ile Asn Tyr Ser Leu Ala Gly Thr Tyr Ile Cys Glu Ala Thr Asn 
305                 310                 315                 320 


Pro Ile Gly Thr Arg Ser Gly Gln Val Glu Val Asn Ile Thr Glu Phe 
                325                 330                 335     


Pro Tyr Thr Pro Ser Pro Pro Glu His Gly Arg Arg Ala Gly Pro Val 
            340                 345                 350         


Pro Thr Ala Ile Ile Gly Gly Val Ala Gly Ser Ile Leu Leu Val Leu 
        355                 360                 365             


Ile Val Val Gly Gly Ile Val Val Ala Leu Arg Arg Arg Arg His Thr 
    370                 375                 380                 


Phe Lys Gly Asp Tyr Ser Thr Lys Lys His Val Tyr Gly Asn Gly Tyr 
385                 390                 395                 400 


Ser Lys Ala Gly Ile Pro Gln His His Pro Pro Met Ala Gln Asn Leu 
                405                 410                 415     


Gln Tyr Pro Asp Asp Ser Asp Asp Glu Lys Lys Ala Gly Pro Leu Gly 
            420                 425                 430         


Gly Ser Ser Tyr Glu Glu Glu Glu Glu Glu Glu Glu Gly Gly Gly Gly 
        435                 440                 445             


Gly Glu Arg Lys Val Gly Gly Pro His Pro Lys Tyr Asp Glu Asp Ala 
    450                 455                 460                 


Lys Arg Pro Tyr Phe Thr Val Asp Glu Ala Glu Ala Arg Gln Asp Gly 
465                 470                 475                 480 


Tyr Gly Asp Arg Thr Leu Gly Tyr Gln Tyr Asp Pro Glu Gln Leu Asp 
                485                 490                 495     


Leu Ala Glu Asn Met Val Ser Gln Asn Asp Gly Ser Phe Ile Ser Lys 
            500                 505                 510         


Lys Glu Trp Tyr Val 
        515         


<210>  2728
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  2728

Met Ala Arg Ala Ala Ala Leu Leu Pro Ser Arg Ser Pro Pro Thr Pro 
1               5                   10                  15      


Leu Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Glu Thr Gly Ala Gln 
            20                  25                  30          


Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly Gly 
        35                  40                  45              


Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu Tyr 
    50                  55                  60                  


Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His Gln 
65                  70                  75                  80  


Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser Pro 
                85                  90                  95      


Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser Thr 
            100                 105                 110         


Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu His 
        115                 120                 125             


Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala Thr 
    130                 135                 140                 


Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile Ala 
145                 150                 155                 160 


Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln Asp 
                165                 170                 175     


Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro Ala 
            180                 185                 190         


Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr Gln 
        195                 200                 205             


Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe Thr 
    210                 215                 220                 


Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys Val 
225                 230                 235                 240 


Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu Ser 
                245                 250                 255     


Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn Trp 
            260                 265                 270         


Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser Asn 
        275                 280                 285             


Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe Pro 
    290                 295                 300                 


Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val Asp 
305                 310                 315                 320 


Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val Gly 
                325                 330                 335     


Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Arg Ala 
            340                 345                 350         


Ser Pro Arg Asp Val Gly Pro Leu Val Trp Gly Ala Val Gly Gly Thr 
        355                 360                 365             


Leu Leu Val Leu Leu Leu Leu Ala Gly Gly Ser Leu Ala Phe Ile Leu 
    370                 375                 380                 


Leu Arg Val Arg Arg Arg Arg Lys Ser Pro Gly Gly Ala Gly Gly Gly 
385                 390                 395                 400 


Ala Ser Gly Asp Gly Gly Phe Tyr Asp Pro Lys Ala Gln Val Leu Gly 
                405                 410                 415     


Asn Gly Asp Pro Val Phe Trp Thr Pro Val Val Pro Gly Pro Met Glu 
            420                 425                 430         


Pro Asp Gly Lys Asp Glu Glu Glu Glu Glu Glu Glu Glu Lys Ala Glu 
        435                 440                 445             


Lys Gly Leu Met Leu Pro Pro Pro Pro Ala Leu Glu Asp Asp Met Glu 
    450                 455                 460                 


Ser Gln Leu Asp Gly Ser Leu Ile Ser Arg Arg Ala Val Tyr Val 
465                 470                 475                 


<210>  2729
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  2729

Met Gly Ser Lys Lys Leu Lys Arg Val Gly Leu Ser Gln Glu Leu Cys 
1               5                   10                  15      


Asp Arg Leu Ser Arg His Gln Ile Leu Thr Cys Gln Asp Phe Leu Cys 
            20                  25                  30          


Leu Ser Pro Leu Glu Leu Met Lys Val Thr Gly Leu Ser Tyr Arg Gly 
        35                  40                  45              


Val His Glu Leu Leu Cys Met Val Ser Arg Ala Cys Ala Pro Lys Met 
    50                  55                  60                  


Gln Thr Ala Tyr Gly Ile Lys Ala Gln Arg Ser Ala Asp Phe Ser Pro 
65                  70                  75                  80  


Ala Phe Leu Ser Thr Thr Leu Ser Ala Leu Asp Glu Ala Leu His Gly 
                85                  90                  95      


Gly Val Ala Cys Gly Ser Leu Thr Glu Ile Thr Gly Pro Pro Gly Cys 
            100                 105                 110         


Gly Lys Thr Gln Phe Cys Ile Met Met Ser Ile Leu Ala Thr Leu Pro 
        115                 120                 125             


Thr Asn Met Gly Gly Leu Glu Gly Ala Val Val Tyr Ile Asp Thr Glu 
    130                 135                 140                 


Ser Ala Phe Ser Ala Glu Arg Leu Val Glu Ile Ala Glu Ser Arg Phe 
145                 150                 155                 160 


Pro Arg Tyr Phe Asn Thr Glu Glu Lys Leu Leu Leu Thr Ser Ser Lys 
                165                 170                 175     


Val His Leu Tyr Arg Glu Leu Thr Cys Asp Glu Val Leu Gln Arg Ile 
            180                 185                 190         


Glu Ser Leu Glu Glu Glu Ile Ile Ser Lys Gly Ile Lys Leu Val Ile 
        195                 200                 205             


Leu Asp Ser Val Ala Ser Val Val Arg Lys Glu Phe Asp Ala Gln Leu 
    210                 215                 220                 


Gln Gly Asn Leu Lys Glu Arg Asn Lys Phe Leu Ala Arg Glu Ala Ser 
225                 230                 235                 240 


Ser Leu Lys Tyr Leu Ala Glu Glu Phe Ser Ile Pro Val Ile Leu Thr 
                245                 250                 255     


Asn Gln Ile Thr Thr His Leu Ser Gly Ala Leu Ala Ser Gln Ala Asp 
            260                 265                 270         


Leu Val Ser Pro Ala Asp Asp Leu Ser Leu Ser Glu Gly Thr Ser Gly 
        275                 280                 285             


Ser Ser Cys Val Ile Ala Ala Leu Gly Asn Thr Trp Ser His Ser Val 
    290                 295                 300                 


Asn Thr Arg Leu Ile Leu Gln Tyr Leu Asp Ser Glu Arg Arg Gln Ile 
305                 310                 315                 320 


Leu Ile Ala Lys Ser Pro Leu Ala Pro Phe Thr Ser Phe Val Tyr Thr 
                325                 330                 335     


Ile Lys Glu Glu Gly Leu Val Leu Gln Ala Tyr Gly Asn Ser 
            340                 345                 350 


<210>  2730
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  2730

Met Ala Glu Thr Ser Ala Leu Pro Thr Gly Phe Gly Glu Leu Glu Val 
1               5                   10                  15      


Leu Ala Val Gly Met Val Leu Leu Val Glu Ala Leu Ser Gly Leu Ser 
            20                  25                  30          


Leu Asn Thr Leu Thr Ile Phe Ser Phe Cys Lys Thr Pro Glu Leu Arg 
        35                  40                  45              


Thr Pro Cys His Leu Leu Val Leu Ser Leu Ala Leu Ala Asp Ser Gly 
    50                  55                  60                  


Ile Ser Leu Asn Ala Leu Val Ala Ala Thr Ser Ser Leu Leu Arg Val 
65                  70                  75                  80  


Ser His Arg Arg Trp Pro Tyr Gly Ser Asp Gly Cys Gln Ala His Gly 
                85                  90                  95      


Phe Gln Gly Phe Val Thr Ala Leu Ala Ser Ile Cys Ser Ser Ala Ala 
            100                 105                 110         


Ile Ala Trp Gly Arg Tyr His His Tyr Cys Thr Arg Ser Gln Leu Ala 
        115                 120                 125             


Trp Asn Ser Ala Val Ser Leu Val Leu Phe Val Trp Leu Ser Ser Ala 
    130                 135                 140                 


Phe Trp Ala Ala Leu Pro Leu Leu Gly Trp Gly His Tyr Asp Tyr Glu 
145                 150                 155                 160 


Pro Leu Gly Thr Cys Cys Thr Leu Asp Tyr Ser Lys Gly Asp Arg Asn 
                165                 170                 175     


Phe Thr Ser Phe Leu Phe Thr Met Ser Phe Phe Asn Phe Ala Met Pro 
            180                 185                 190         


Leu Phe Ile Thr Ile Thr Ser Tyr Ser Leu Met Glu Gln Lys Leu Gly 
        195                 200                 205             


Lys Ser Gly His Leu Gln Val Asn Thr Thr Leu Pro Ala Arg Thr Leu 
    210                 215                 220                 


Leu Leu Gly Trp Gly Pro Tyr Ala Ile Leu Tyr Leu Tyr Ala Val Ile 
225                 230                 235                 240 


Ala Asp Val Thr Ser Ile Ser Pro Lys Leu Gln Met Val Pro Ala Leu 
                245                 250                 255     


Ile Ala Lys Met Val Pro Thr Ile Asn Ala Ile Asn Tyr Ala Leu Gly 
            260                 265                 270         


Asn Glu Met Val Cys Arg Gly Ile Trp Gln Cys Leu Ser Pro Gln Lys 
        275                 280                 285             


Arg Glu Lys Asp Arg Thr Lys 
    290                 295 


<210>  2731
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  2731

Met Ala Leu Glu Lys Ser Leu Val Arg Leu Leu Leu Leu Val Leu Ile 
1               5                   10                  15      


Leu Leu Val Leu Gly Trp Val Gln Pro Ser Leu Gly Lys Glu Ser Arg 
            20                  25                  30          


Ala Lys Lys Phe Gln Arg Gln His Met Asp Ser Asp Ser Ser Pro Ser 
        35                  40                  45              


Ser Ser Ser Thr Tyr Cys Asn Gln Met Met Arg Arg Arg Asn Met Thr 
    50                  55                  60                  


Gln Gly Arg Cys Lys Pro Val Asn Thr Phe Val His Glu Pro Leu Val 
65                  70                  75                  80  


Asp Val Gln Asn Val Cys Phe Gln Glu Lys Val Thr Cys Lys Asn Gly 
                85                  90                  95      


Gln Gly Asn Cys Tyr Lys Ser Asn Ser Ser Met His Ile Thr Asp Cys 
            100                 105                 110         


Arg Leu Thr Asn Gly Ser Arg Tyr Pro Asn Cys Ala Tyr Arg Thr Ser 
        115                 120                 125             


Pro Lys Glu Arg His Ile Ile Val Ala Cys Glu Gly Ser Pro Tyr Val 
    130                 135                 140                 


Pro Val His Phe Asp Ala Ser Val Glu Asp Ser Thr 
145                 150                 155     


<210>  2732
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  2732

Met Ala Leu Gln Arg Thr His Ser Leu Leu Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Leu Leu Gly Leu Gly Leu Val Gln Pro Ser Tyr Gly Gln Asp Gly Met 
            20                  25                  30          


Tyr Gln Arg Phe Leu Arg Gln His Val His Pro Glu Glu Thr Gly Gly 
        35                  40                  45              


Ser Asp Arg Tyr Cys Asn Leu Met Met Gln Arg Arg Lys Met Thr Leu 
    50                  55                  60                  


Tyr His Cys Lys Arg Phe Asn Thr Phe Ile His Glu Asp Ile Trp Asn 
65                  70                  75                  80  


Ile Arg Ser Ile Cys Ser Thr Thr Asn Ile Gln Cys Lys Asn Gly Lys 
                85                  90                  95      


Met Asn Cys His Glu Gly Val Val Lys Val Thr Asp Cys Arg Asp Thr 
            100                 105                 110         


Gly Ser Ser Arg Ala Pro Asn Cys Arg Tyr Arg Ala Ile Ala Ser Thr 
        115                 120                 125             


Arg Arg Val Val Ile Ala Cys Glu Gly Asn Pro Gln Val Pro Val His 
    130                 135                 140                 


Phe Asp Gly 
145         


<210>  2733
<211>  1378
<212>  PRT
<213>  Homo sapiens

<400>  2733

Met Ser Leu Leu Met Phe Thr Gln Leu Leu Leu Cys Gly Phe Leu Tyr 
1               5                   10                  15      


Val Arg Val Asp Gly Ser Arg Leu Arg Gln Glu Asp Phe Pro Pro Arg 
            20                  25                  30          


Ile Val Glu His Pro Ser Asp Val Ile Val Ser Lys Gly Glu Pro Thr 
        35                  40                  45              


Thr Leu Asn Cys Lys Ala Glu Gly Arg Pro Thr Pro Thr Ile Glu Trp 
    50                  55                  60                  


Tyr Lys Asp Gly Glu Arg Val Glu Thr Asp Lys Asp Asp Pro Arg Ser 
65                  70                  75                  80  


His Arg Met Leu Leu Pro Ser Gly Ser Leu Phe Phe Leu Arg Ile Val 
                85                  90                  95      


His Gly Arg Arg Ser Lys Pro Asp Glu Gly Ser Tyr Val Cys Val Ala 
            100                 105                 110         


Arg Asn Tyr Leu Gly Glu Ala Val Ser Arg Asn Ala Ser Leu Glu Val 
        115                 120                 125             


Ala Leu Leu Arg Asp Asp Phe Arg Gln Asn Pro Thr Asp Val Val Val 
    130                 135                 140                 


Ala Ala Gly Glu Pro Ala Ile Leu Glu Cys Gln Pro Pro Arg Gly His 
145                 150                 155                 160 


Pro Glu Pro Thr Ile Tyr Trp Lys Lys Asp Lys Val Arg Ile Asp Asp 
                165                 170                 175     


Lys Glu Glu Arg Ile Ser Ile Arg Gly Gly Lys Leu Met Ile Ser Asn 
            180                 185                 190         


Thr Arg Lys Ser Asp Ala Gly Met Tyr Thr Cys Val Gly Thr Asn Met 
        195                 200                 205             


Val Gly Glu Arg Asp Ser Asp Pro Ala Glu Leu Thr Val Phe Glu Arg 
    210                 215                 220                 


Pro Thr Phe Leu Arg Arg Pro Ile Asn Gln Val Val Leu Glu Glu Glu 
225                 230                 235                 240 


Ala Val Glu Phe Arg Cys Gln Val Gln Gly Asp Pro Gln Pro Thr Val 
                245                 250                 255     


Arg Trp Lys Lys Asp Asp Ala Asp Leu Pro Arg Gly Arg Tyr Asp Ile 
            260                 265                 270         


Lys Asp Asp Tyr Thr Leu Arg Ile Lys Lys Thr Met Ser Thr Asp Glu 
        275                 280                 285             


Gly Thr Tyr Met Cys Ile Ala Glu Asn Arg Val Gly Lys Met Glu Ala 
    290                 295                 300                 


Ser Ala Thr Leu Thr Val Arg Ala Pro Pro Gln Phe Val Val Arg Pro 
305                 310                 315                 320 


Arg Asp Gln Ile Val Ala Gln Gly Arg Thr Val Thr Phe Pro Cys Glu 
                325                 330                 335     


Thr Lys Gly Asn Pro Gln Pro Ala Val Phe Trp Gln Lys Glu Gly Ser 
            340                 345                 350         


Gln Asn Leu Leu Phe Pro Asn Gln Pro Gln Gln Pro Asn Ser Arg Cys 
        355                 360                 365             


Ser Val Ser Pro Thr Gly Asp Leu Thr Ile Thr Asn Ile Gln Arg Ser 
    370                 375                 380                 


Asp Ala Gly Tyr Tyr Ile Cys Gln Ala Leu Thr Val Ala Gly Ser Ile 
385                 390                 395                 400 


Leu Ala Lys Ala Gln Leu Glu Val Thr Asp Val Leu Thr Asp Arg Pro 
                405                 410                 415     


Pro Pro Ile Ile Leu Gln Gly Pro Ala Asn Gln Thr Leu Ala Val Asp 
            420                 425                 430         


Gly Thr Ala Leu Leu Lys Cys Lys Ala Thr Gly Asp Pro Leu Pro Val 
        435                 440                 445             


Ile Ser Trp Leu Lys Glu Gly Phe Thr Phe Pro Gly Arg Asp Pro Arg 
    450                 455                 460                 


Ala Thr Ile Gln Glu Gln Gly Thr Leu Gln Ile Lys Asn Leu Arg Ile 
465                 470                 475                 480 


Ser Asp Thr Gly Thr Tyr Thr Cys Val Ala Thr Ser Ser Ser Gly Glu 
                485                 490                 495     


Thr Ser Trp Ser Ala Val Leu Asp Val Thr Glu Ser Gly Ala Thr Ile 
            500                 505                 510         


Ser Lys Asn Tyr Asp Leu Ser Asp Leu Pro Gly Pro Pro Ser Lys Pro 
        515                 520                 525             


Gln Val Thr Asp Val Thr Lys Asn Ser Val Thr Leu Ser Trp Gln Pro 
    530                 535                 540                 


Gly Thr Pro Gly Thr Leu Pro Ala Ser Ala Tyr Ile Ile Glu Ala Phe 
545                 550                 555                 560 


Ser Gln Ser Val Ser Asn Ser Trp Gln Thr Val Ala Asn His Val Lys 
                565                 570                 575     


Thr Thr Leu Tyr Thr Val Arg Gly Leu Arg Pro Asn Thr Ile Tyr Leu 
            580                 585                 590         


Phe Met Val Arg Ala Ile Asn Pro Gln Gly Leu Ser Asp Pro Ser Pro 
        595                 600                 605             


Met Ser Asp Pro Val Arg Thr Gln Asp Ile Ser Pro Pro Ala Gln Gly 
    610                 615                 620                 


Val Asp His Arg Gln Val Gln Lys Glu Leu Gly Asp Val Leu Val Arg 
625                 630                 635                 640 


Leu His Asn Pro Val Val Leu Thr Pro Thr Thr Val Gln Val Thr Trp 
                645                 650                 655     


Thr Val Asp Arg Gln Pro Gln Phe Ile Gln Gly Tyr Arg Val Met Tyr 
            660                 665                 670         


Arg Gln Thr Ser Gly Leu Gln Ala Thr Ser Ser Trp Gln Asn Leu Asp 
        675                 680                 685             


Ala Lys Val Pro Thr Glu Arg Ser Ala Val Leu Val Asn Leu Lys Lys 
    690                 695                 700                 


Gly Val Thr Tyr Glu Ile Lys Val Arg Pro Tyr Phe Asn Glu Phe Gln 
705                 710                 715                 720 


Gly Met Asp Ser Glu Ser Lys Thr Val Arg Thr Thr Glu Glu Ala Pro 
                725                 730                 735     


Ser Ala Pro Pro Gln Ser Val Thr Val Leu Thr Val Gly Ser Tyr Asn 
            740                 745                 750         


Ser Thr Ser Ile Ser Val Ser Trp Asp Pro Pro Pro Pro Asp His Gln 
        755                 760                 765             


Asn Gly Ile Ile Gln Glu Tyr Lys Ile Trp Cys Leu Gly Asn Glu Thr 
    770                 775                 780                 


Arg Phe His Ile Asn Lys Thr Val Asp Ala Ala Ile Arg Ser Val Ile 
785                 790                 795                 800 


Ile Gly Gly Leu Phe Pro Gly Ile Gln Tyr Arg Val Glu Val Ala Ala 
                805                 810                 815     


Ser Thr Ser Ala Gly Val Gly Val Lys Ser Glu Pro Gln Pro Ile Ile 
            820                 825                 830         


Ile Gly Arg Arg Asn Glu Val Val Ile Thr Glu Asn Asn Asn Ser Ile 
        835                 840                 845             


Thr Glu Gln Ile Thr Asp Val Val Lys Gln Pro Ala Phe Ile Ala Gly 
    850                 855                 860                 


Ile Gly Gly Ala Cys Trp Val Ile Leu Met Gly Phe Ser Ile Trp Leu 
865                 870                 875                 880 


Tyr Trp Arg Arg Lys Lys Arg Lys Gly Leu Ser Asn Tyr Ala Val Thr 
                885                 890                 895     


Phe Gln Arg Gly Asp Gly Gly Leu Met Ser Asn Gly Ser Arg Pro Gly 
            900                 905                 910         


Leu Leu Asn Ala Gly Asp Pro Ser Tyr Pro Trp Leu Ala Asp Ser Trp 
        915                 920                 925             


Pro Ala Thr Ser Leu Pro Val Asn Asn Ser Asn Ser Gly Pro Asn Glu 
    930                 935                 940                 


Ile Gly Asn Phe Gly Arg Gly Asp Val Leu Pro Pro Val Pro Gly Gln 
945                 950                 955                 960 


Gly Asp Lys Thr Ala Thr Met Leu Ser Asp Gly Ala Ile Tyr Ser Ser 
                965                 970                 975     


Ile Asp Phe Thr Thr Lys Thr Ser Tyr Asn Ser Ser Ser Gln Ile Thr 
            980                 985                 990         


Gln Ala Thr Pro Tyr Ala Thr Thr  Gln Ile Leu His Ser  Asn Ser Ile 
        995                 1000                 1005             


His Glu  Leu Ala Val Asp Leu  Pro Asp Pro Gln Trp  Lys Ser Ser 
    1010                 1015                 1020             


Ile Gln  Gln Lys Thr Asp Leu  Met Gly Phe Gly Tyr  Ser Leu Pro 
    1025                 1030                 1035             


Asp Gln  Asn Lys Gly Asn Asn  Gly Gly Lys Gly Gly  Lys Lys Lys 
    1040                 1045                 1050             


Lys Asn  Lys Asn Ser Ser Lys  Pro Gln Lys Asn Asn  Gly Ser Thr 
    1055                 1060                 1065             


Trp Ala  Asn Val Pro Leu Pro  Pro Pro Pro Val Gln  Pro Leu Pro 
    1070                 1075                 1080             


Gly Thr  Glu Leu Glu His Tyr  Ala Val Glu Gln Gln  Glu Asn Gly 
    1085                 1090                 1095             


Tyr Asp  Ser Asp Ser Trp Cys  Pro Pro Leu Pro Val  Gln Thr Tyr 
    1100                 1105                 1110             


Leu His  Gln Gly Leu Glu Asp  Glu Leu Glu Glu Asp  Asp Asp Arg 
    1115                 1120                 1125             


Val Pro  Thr Pro Pro Val Arg  Gly Val Ala Ser Ser  Pro Ala Ile 
    1130                 1135                 1140             


Ser Phe  Gly Gln Gln Ser Thr  Ala Thr Leu Thr Pro  Ser Pro Arg 
    1145                 1150                 1155             


Glu Glu  Met Gln Pro Met Leu  Gln Ala His Leu Asp  Glu Leu Thr 
    1160                 1165                 1170             


Arg Ala  Tyr Gln Phe Asp Ile  Ala Lys Gln Thr Trp  His Ile Gln 
    1175                 1180                 1185             


Ser Asn  Asn Gln Pro Pro Gln  Pro Pro Val Pro Pro  Leu Gly Tyr 
    1190                 1195                 1200             


Val Ser  Gly Ala Leu Ile Ser  Asp Leu Glu Thr Asp  Val Ala Asp 
    1205                 1210                 1215             


Asp Asp  Ala Asp Asp Glu Glu  Glu Ala Leu Glu Ile  Pro Arg Pro 
    1220                 1225                 1230             


Leu Arg  Ala Leu Asp Gln Thr  Pro Gly Ser Ser Met  Asp Asn Leu 
    1235                 1240                 1245             


Asp Ser  Ser Val Thr Gly Lys  Ala Phe Thr Ser Ser  Gln Arg Pro 
    1250                 1255                 1260             


Arg Pro  Thr Ser Pro Phe Ser  Thr Asp Ser Asn Thr  Ser Ala Ala 
    1265                 1270                 1275             


Leu Ser  Gln Ser Gln Arg Pro  Arg Pro Thr Lys Lys  His Lys Gly 
    1280                 1285                 1290             


Gly Arg  Met Asp Gln Gln Pro  Ala Leu Pro His Arg  Arg Glu Gly 
    1295                 1300                 1305             


Met Thr  Asp Glu Glu Ala Leu  Val Pro Tyr Ser Lys  Pro Ser Phe 
    1310                 1315                 1320             


Pro Ser  Pro Gly Gly His Ser  Ser Ser Gly Thr Ala  Ser Ser Lys 
    1325                 1330                 1335             


Gly Ser  Thr Gly Pro Arg Lys  Thr Glu Val Leu Arg  Ala Gly His 
    1340                 1345                 1350             


Gln Arg  Asn Ala Ser Asp Leu  Leu Asp Ile Gly Tyr  Met Gly Ser 
    1355                 1360                 1365             


Asn Ser  Gln Gly Gln Phe Thr  Gly Glu Leu 
    1370                 1375             


<210>  2734
<211>  2347
<212>  PRT
<213>  Homo sapiens

<400>  2734

Met Lys Asn Ile Tyr Cys Leu Ile Pro Lys Leu Val Asn Phe Ala Thr 
1               5                   10                  15      


Leu Gly Cys Leu Trp Ile Ser Val Val Gln Cys Thr Val Leu Asn Ser 
            20                  25                  30          


Cys Leu Lys Ser Cys Val Thr Asn Leu Gly Gln Gln Leu Asp Leu Gly 
        35                  40                  45              


Thr Pro His Asn Leu Ser Glu Pro Cys Ile Gln Gly Cys His Phe Trp 
    50                  55                  60                  


Asn Ser Val Asp Gln Lys Asn Cys Ala Leu Lys Cys Arg Glu Ser Cys 
65                  70                  75                  80  


Glu Val Gly Cys Ser Ser Ala Glu Gly Ala Tyr Glu Glu Glu Val Leu 
                85                  90                  95      


Glu Asn Ala Asp Leu Pro Thr Ala Pro Phe Ala Ser Ser Ile Gly Ser 
            100                 105                 110         


His Asn Met Thr Leu Arg Trp Lys Ser Ala Asn Phe Ser Gly Val Lys 
        115                 120                 125             


Tyr Ile Ile Gln Trp Lys Tyr Ala Gln Leu Leu Gly Ser Trp Thr Tyr 
    130                 135                 140                 


Thr Lys Thr Val Ser Arg Pro Ser Tyr Val Val Lys Pro Leu His Pro 
145                 150                 155                 160 


Phe Thr Glu Tyr Ile Phe Arg Val Val Trp Ile Phe Thr Ala Gln Leu 
                165                 170                 175     


Gln Leu Tyr Ser Pro Pro Ser Pro Ser Tyr Arg Thr His Pro His Gly 
            180                 185                 190         


Val Pro Glu Thr Ala Pro Leu Ile Arg Asn Ile Glu Ser Ser Ser Pro 
        195                 200                 205             


Asp Thr Val Glu Val Ser Trp Asp Pro Pro Gln Phe Pro Gly Gly Pro 
    210                 215                 220                 


Ile Leu Gly Tyr Asn Leu Arg Leu Ile Ser Lys Asn Gln Lys Leu Asp 
225                 230                 235                 240 


Ala Gly Thr Gln Arg Thr Ser Phe Gln Phe Tyr Ser Thr Leu Pro Asn 
                245                 250                 255     


Thr Ile Tyr Arg Phe Ser Ile Ala Ala Val Asn Glu Val Gly Glu Gly 
            260                 265                 270         


Pro Glu Ala Glu Ser Ser Ile Thr Thr Ser Ser Ser Ala Val Gln Gln 
        275                 280                 285             


Glu Glu Gln Trp Leu Phe Leu Ser Arg Lys Thr Ser Leu Arg Lys Arg 
    290                 295                 300                 


Ser Leu Lys His Leu Val Asp Glu Ala His Cys Leu Arg Leu Asp Ala 
305                 310                 315                 320 


Ile Tyr His Asn Ile Thr Gly Ile Ser Val Asp Val His Gln Gln Ile 
                325                 330                 335     


Val Tyr Phe Ser Glu Gly Thr Leu Ile Trp Ala Lys Lys Ala Ala Asn 
            340                 345                 350         


Met Ser Asp Val Ser Asp Leu Arg Ile Phe Tyr Arg Gly Ser Gly Leu 
        355                 360                 365             


Ile Ser Ser Ile Ser Ile Asp Trp Leu Tyr Gln Arg Met Tyr Phe Ile 
    370                 375                 380                 


Met Asp Glu Leu Val Cys Val Cys Asp Leu Glu Asn Cys Ser Asn Ile 
385                 390                 395                 400 


Glu Glu Ile Thr Pro Pro Ser Ile Ser Ala Pro Gln Lys Ile Val Ala 
                405                 410                 415     


Asp Ser Tyr Asn Gly Tyr Val Phe Tyr Leu Leu Arg Asp Gly Ile Tyr 
            420                 425                 430         


Arg Ala Asp Leu Pro Val Pro Ser Gly Arg Cys Ala Glu Ala Val Arg 
        435                 440                 445             


Ile Val Glu Ser Cys Thr Leu Lys Asp Phe Ala Ile Lys Pro Gln Ala 
    450                 455                 460                 


Lys Arg Ile Ile Tyr Phe Asn Asp Thr Ala Gln Val Phe Met Ser Thr 
465                 470                 475                 480 


Phe Leu Asp Gly Ser Ala Ser His Leu Ile Leu Pro Arg Ile Pro Phe 
                485                 490                 495     


Ala Asp Val Lys Ser Phe Ala Cys Glu Asn Asn Asp Phe Leu Val Thr 
            500                 505                 510         


Asp Gly Lys Val Ile Phe Gln Gln Asp Ala Leu Ser Phe Asn Glu Phe 
        515                 520                 525             


Ile Val Gly Cys Asp Leu Ser His Ile Glu Glu Phe Gly Phe Gly Asn 
    530                 535                 540                 


Leu Val Ile Phe Gly Ser Ser Ser Gln Leu His Pro Leu Pro Gly Arg 
545                 550                 555                 560 


Pro Gln Glu Leu Ser Val Leu Phe Gly Ser His Gln Ala Leu Val Gln 
                565                 570                 575     


Trp Lys Pro Pro Ala Leu Ala Ile Gly Ala Asn Val Ile Leu Ile Ser 
            580                 585                 590         


Asp Ile Ile Glu Leu Phe Glu Leu Gly Pro Ser Ala Trp Gln Asn Trp 
        595                 600                 605             


Thr Tyr Glu Val Lys Val Ser Thr Gln Asp Pro Pro Glu Val Thr His 
    610                 615                 620                 


Ile Phe Leu Asn Ile Ser Gly Thr Met Leu Asn Val Pro Glu Leu Gln 
625                 630                 635                 640 


Ser Ala Met Lys Tyr Lys Val Ser Val Arg Ala Ser Ser Pro Lys Arg 
                645                 650                 655     


Pro Gly Pro Trp Ser Glu Pro Ser Val Gly Thr Thr Leu Val Pro Ala 
            660                 665                 670         


Ser Glu Pro Pro Phe Ile Met Ala Val Lys Glu Asp Gly Leu Trp Ser 
        675                 680                 685             


Lys Pro Leu Asn Ser Phe Gly Pro Gly Glu Phe Leu Ser Ser Asp Ile 
    690                 695                 700                 


Gly Asn Val Ser Asp Met Asp Trp Tyr Asn Asn Ser Leu Tyr Tyr Ser 
705                 710                 715                 720 


Asp Thr Lys Gly Asp Val Phe Val Trp Leu Leu Asn Gly Thr Asp Ile 
                725                 730                 735     


Ser Glu Asn Tyr His Leu Pro Ser Ile Ala Gly Ala Gly Ala Leu Ala 
            740                 745                 750         


Phe Glu Trp Leu Gly His Phe Leu Tyr Trp Ala Gly Lys Thr Tyr Val 
        755                 760                 765             


Ile Gln Arg Gln Ser Val Leu Thr Gly His Thr Asp Ile Val Thr His 
    770                 775                 780                 


Val Lys Leu Leu Val Asn Asp Met Val Val Asp Ser Val Gly Gly Tyr 
785                 790                 795                 800 


Leu Tyr Trp Thr Thr Leu Tyr Ser Val Glu Ser Thr Arg Leu Asn Gly 
                805                 810                 815     


Glu Ser Ser Leu Val Leu Gln Thr Gln Pro Trp Phe Ser Gly Lys Lys 
            820                 825                 830         


Val Ile Ala Leu Thr Leu Asp Leu Ser Asp Gly Leu Leu Tyr Trp Leu 
        835                 840                 845             


Val Gln Asp Ser Gln Cys Ile His Leu Tyr Thr Ala Val Leu Arg Gly 
    850                 855                 860                 


Gln Ser Thr Gly Asp Thr Thr Ile Thr Glu Phe Ala Ala Trp Ser Thr 
865                 870                 875                 880 


Ser Glu Ile Ser Gln Asn Ala Leu Met Tyr Tyr Ser Gly Arg Leu Phe 
                885                 890                 895     


Trp Ile Asn Gly Phe Arg Ile Ile Thr Thr Gln Glu Ile Gly Gln Lys 
            900                 905                 910         


Thr Ser Val Ser Val Leu Glu Pro Ala Arg Phe Asn Gln Phe Thr Ile 
        915                 920                 925             


Ile Gln Thr Ser Leu Lys Pro Leu Pro Gly Asn Phe Ser Phe Thr Pro 
    930                 935                 940                 


Lys Val Ile Pro Asp Ser Val Gln Glu Ser Ser Phe Arg Ile Glu Gly 
945                 950                 955                 960 


Asn Ala Ser Ser Phe Gln Ile Leu Trp Asn Gly Pro Pro Ala Val Asp 
                965                 970                 975     


Trp Gly Val Val Phe Tyr Ser Val Glu Phe Ser Ala His Ser Lys Phe 
            980                 985                 990         


Leu Ala Ser Glu Gln His Ser Leu  Pro Val Phe Thr Val  Glu Gly Leu 
        995                 1000                 1005             


Glu Pro  Tyr Ala Leu Phe Asn  Leu Ser Val Thr Pro  Tyr Thr Tyr 
    1010                 1015                 1020             


Trp Gly  Lys Gly Pro Lys Thr  Ser Leu Ser Leu Arg  Ala Pro Glu 
    1025                 1030                 1035             


Thr Val  Pro Ser Ala Pro Glu  Asn Pro Arg Ile Phe  Ile Leu Pro 
    1040                 1045                 1050             


Ser Gly  Lys Cys Cys Asn Lys  Asn Glu Val Val Val  Glu Phe Arg 
    1055                 1060                 1065             


Trp Asn  Lys Pro Lys His Glu  Asn Gly Val Leu Thr  Lys Phe Glu 
    1070                 1075                 1080             


Ile Phe  Tyr Asn Ile Ser Asn  Gln Ser Ile Thr Asn  Lys Thr Cys 
    1085                 1090                 1095             


Glu Asp  Trp Ile Ala Val Asn  Val Thr Pro Ser Val  Met Ser Phe 
    1100                 1105                 1110             


Gln Leu  Glu Gly Met Ser Pro  Arg Cys Phe Ile Ala  Phe Gln Val 
    1115                 1120                 1125             


Arg Ala  Phe Thr Ser Lys Gly  Pro Gly Pro Tyr Ala  Asp Val Val 
    1130                 1135                 1140             


Lys Ser  Thr Thr Ser Glu Ile  Asn Pro Phe Pro His  Leu Ile Thr 
    1145                 1150                 1155             


Leu Leu  Gly Asn Lys Ile Val  Phe Leu Asp Met Asp  Gln Asn Gln 
    1160                 1165                 1170             


Val Val  Trp Thr Phe Ser Ala  Glu Arg Val Ile Ser  Ala Val Cys 
    1175                 1180                 1185             


Tyr Thr  Ala Asp Asn Glu Met  Gly Tyr Tyr Ala Glu  Gly Asp Ser 
    1190                 1195                 1200             


Leu Phe  Leu Leu His Leu His  Asn Arg Ser Ser Ser  Glu Leu Phe 
    1205                 1210                 1215             


Gln Asp  Ser Leu Val Phe Asp  Ile Thr Val Ile Thr  Ile Asp Trp 
    1220                 1225                 1230             


Ile Ser  Arg His Leu Tyr Phe  Ala Leu Lys Glu Ser  Gln Asn Gly 
    1235                 1240                 1245             


Met Gln  Val Phe Asp Val Asp  Leu Glu His Lys Val  Lys Tyr Pro 
    1250                 1255                 1260             


Arg Glu  Val Lys Ile His Asn  Arg Asn Ser Thr Ile  Ile Ser Phe 
    1265                 1270                 1275             


Ser Val  Tyr Pro Leu Leu Ser  Arg Leu Tyr Trp Thr  Glu Val Ser 
    1280                 1285                 1290             


Asn Phe  Gly Tyr Gln Met Phe  Tyr Tyr Ser Ile Ile  Ser His Thr 
    1295                 1300                 1305             


Leu His  Arg Ile Leu Gln Pro  Thr Ala Thr Asn Gln  Gln Asn Lys 
    1310                 1315                 1320             


Arg Asn  Gln Cys Ser Cys Asn  Val Thr Glu Phe Glu  Leu Ser Gly 
    1325                 1330                 1335             


Ala Met  Ala Ile Asp Thr Ser  Asn Leu Glu Lys Pro  Leu Ile Tyr 
    1340                 1345                 1350             


Phe Ala  Lys Ala Gln Glu Ile  Trp Ala Met Asp Leu  Glu Gly Cys 
    1355                 1360                 1365             


Gln Cys  Trp Arg Val Ile Thr  Val Pro Ala Met Leu  Ala Gly Lys 
    1370                 1375                 1380             


Thr Leu  Val Ser Leu Thr Val  Asp Gly Asp Leu Ile  Tyr Trp Ile 
    1385                 1390                 1395             


Ile Thr  Ala Lys Asp Ser Thr  Gln Ile Tyr Gln Ala  Lys Lys Gly 
    1400                 1405                 1410             


Asn Gly  Ala Ile Val Ser Gln  Val Lys Ala Leu Arg  Ser Arg His 
    1415                 1420                 1425             


Ile Leu  Ala Tyr Ser Ser Val  Met Gln Pro Phe Pro  Asp Lys Ala 
    1430                 1435                 1440             


Phe Leu  Ser Leu Ala Ser Asp  Thr Val Glu Pro Thr  Ile Leu Asn 
    1445                 1450                 1455             


Ala Thr  Asn Thr Ser Leu Thr  Ile Arg Leu Pro Leu  Ala Lys Thr 
    1460                 1465                 1470             


Asn Leu  Thr Trp Tyr Gly Ile  Thr Ser Pro Thr Pro  Thr Tyr Leu 
    1475                 1480                 1485             


Val Tyr  Tyr Ala Glu Val Asn  Asp Arg Lys Asn Ser  Ser Asp Leu 
    1490                 1495                 1500             


Lys Tyr  Arg Ile Leu Glu Phe  Gln Asp Ser Ile Ala  Leu Ile Glu 
    1505                 1510                 1515             


Asp Leu  Gln Pro Phe Ser Thr  Tyr Met Ile Gln Ile  Ala Val Lys 
    1520                 1525                 1530             


Asn Tyr  Tyr Ser Asp Pro Leu  Glu His Leu Pro Pro  Gly Lys Glu 
    1535                 1540                 1545             


Ile Trp  Gly Lys Thr Lys Asn  Gly Val Pro Glu Ala  Val Gln Leu 
    1550                 1555                 1560             


Ile Asn  Thr Thr Val Arg Ser  Asp Thr Ser Leu Ile  Ile Ser Trp 
    1565                 1570                 1575             


Arg Glu  Ser His Lys Pro Asn  Gly Pro Lys Glu Ser  Val Arg Tyr 
    1580                 1585                 1590             


Gln Leu  Ala Ile Ser His Leu  Ala Leu Ile Pro Glu  Thr Pro Leu 
    1595                 1600                 1605             


Arg Gln  Ser Glu Phe Pro Asn  Gly Arg Leu Thr Leu  Leu Val Thr 
    1610                 1615                 1620             


Arg Leu  Ser Gly Gly Asn Ile  Tyr Val Leu Lys Val  Leu Ala Cys 
    1625                 1630                 1635             


His Ser  Glu Glu Met Trp Cys  Thr Glu Ser His Pro  Val Thr Val 
    1640                 1645                 1650             


Glu Met  Phe Asn Thr Pro Glu  Lys Pro Tyr Ser Leu  Val Pro Glu 
    1655                 1660                 1665             


Asn Thr  Ser Leu Gln Phe Asn  Trp Lys Ala Pro Leu  Asn Val Asn 
    1670                 1675                 1680             


Leu Ile  Arg Phe Trp Val Glu  Leu Gln Lys Trp Lys  Tyr Asn Glu 
    1685                 1690                 1695             


Phe Tyr  His Val Lys Thr Ser  Cys Ser Gln Gly Pro  Ala Tyr Val 
    1700                 1705                 1710             


Cys Asn  Ile Thr Asn Leu Gln  Pro Tyr Thr Ser Tyr  Asn Val Arg 
    1715                 1720                 1725             


Val Val  Val Val Tyr Lys Thr  Gly Glu Asn Ser Thr  Ser Leu Pro 
    1730                 1735                 1740             


Glu Ser  Phe Lys Thr Lys Ala  Gly Val Pro Asn Lys  Pro Gly Ile 
    1745                 1750                 1755             


Pro Lys  Leu Leu Glu Gly Ser  Lys Asn Ser Ile Gln  Trp Glu Lys 
    1760                 1765                 1770             


Ala Glu  Asp Asn Gly Cys Arg  Ile Thr Tyr Tyr Ile  Leu Glu Ile 
    1775                 1780                 1785             


Arg Lys  Ser Thr Ser Asn Asn  Leu Gln Asn Gln Asn  Leu Arg Trp 
    1790                 1795                 1800             


Lys Met  Thr Phe Asn Gly Ser  Cys Ser Ser Val Cys  Thr Trp Lys 
    1805                 1810                 1815             


Ser Lys  Asn Leu Lys Gly Ile  Phe Gln Phe Arg Val  Val Ala Ala 
    1820                 1825                 1830             


Asn Asn  Leu Gly Phe Gly Glu  Tyr Ser Gly Ile Ser  Glu Asn Ile 
    1835                 1840                 1845             


Ile Leu  Val Gly Asp Asp Phe  Trp Ile Pro Glu Thr  Ser Phe Ile 
    1850                 1855                 1860             


Leu Thr  Ile Ile Val Gly Ile  Phe Leu Val Val Thr  Ile Pro Leu 
    1865                 1870                 1875             


Thr Phe  Val Trp His Arg Arg  Leu Lys Asn Gln Lys  Ser Ala Lys 
    1880                 1885                 1890             


Glu Gly  Val Thr Val Leu Ile  Asn Glu Asp Lys Glu  Leu Ala Glu 
    1895                 1900                 1905             


Leu Arg  Gly Leu Ala Ala Gly  Val Gly Leu Ala Asn  Ala Cys Tyr 
    1910                 1915                 1920             


Ala Ile  His Thr Leu Pro Thr  Gln Glu Glu Ile Glu  Asn Leu Pro 
    1925                 1930                 1935             


Ala Phe  Pro Arg Glu Lys Leu  Thr Leu Arg Leu Leu  Leu Gly Ser 
    1940                 1945                 1950             


Gly Ala  Phe Gly Glu Val Tyr  Glu Gly Thr Ala Val  Asp Ile Leu 
    1955                 1960                 1965             


Gly Val  Gly Ser Gly Glu Ile  Lys Val Ala Val Lys  Thr Leu Lys 
    1970                 1975                 1980             


Lys Gly  Ser Thr Asp Gln Glu  Lys Ile Glu Phe Leu  Lys Glu Ala 
    1985                 1990                 1995             


His Leu  Met Ser Lys Phe Asn  His Pro Asn Ile Leu  Lys Gln Leu 
    2000                 2005                 2010             


Gly Val  Cys Leu Leu Asn Glu  Pro Gln Tyr Ile Ile  Leu Glu Leu 
    2015                 2020                 2025             


Met Glu  Gly Gly Asp Leu Leu  Thr Tyr Leu Arg Lys  Ala Arg Met 
    2030                 2035                 2040             


Ala Thr  Phe Tyr Gly Pro Leu  Leu Thr Leu Val Asp  Leu Val Asp 
    2045                 2050                 2055             


Leu Cys  Val Asp Ile Ser Lys  Gly Cys Val Tyr Leu  Glu Arg Met 
    2060                 2065                 2070             


His Phe  Ile His Arg Asp Leu  Ala Ala Arg Asn Cys  Leu Val Ser 
    2075                 2080                 2085             


Val Lys  Asp Tyr Thr Ser Pro  Arg Ile Val Lys Ile  Gly Asp Phe 
    2090                 2095                 2100             


Gly Leu  Ala Arg Asp Ile Tyr  Lys Asn Asp Tyr Tyr  Arg Lys Arg 
    2105                 2110                 2115             


Gly Glu  Gly Leu Leu Pro Val  Arg Trp Met Ala Pro  Glu Ser Leu 
    2120                 2125                 2130             


Met Asp  Gly Ile Phe Thr Thr  Gln Ser Asp Val Trp  Ser Phe Gly 
    2135                 2140                 2145             


Ile Leu  Ile Trp Glu Ile Leu  Thr Leu Gly His Gln  Pro Tyr Pro 
    2150                 2155                 2160             


Ala His  Ser Asn Leu Asp Val  Leu Asn Tyr Val Gln  Thr Gly Gly 
    2165                 2170                 2175             


Arg Leu  Glu Pro Pro Arg Asn  Cys Pro Asp Asp Leu  Trp Asn Leu 
    2180                 2185                 2190             


Met Thr  Gln Cys Trp Ala Gln  Glu Pro Asp Gln Arg  Pro Thr Phe 
    2195                 2200                 2205             


His Arg  Ile Gln Asp Gln Leu  Gln Leu Phe Arg Asn  Phe Phe Leu 
    2210                 2215                 2220             


Asn Ser  Ile Tyr Lys Ser Arg  Asp Glu Ala Asn Asn  Ser Gly Val 
    2225                 2230                 2235             


Ile Asn  Glu Ser Phe Glu Gly  Glu Asp Gly Asp Val  Ile Cys Leu 
    2240                 2245                 2250             


Asn Ser  Asp Asp Ile Met Pro  Val Ala Leu Met Glu  Thr Lys Asn 
    2255                 2260                 2265             


Arg Glu  Gly Leu Asn Tyr Met  Val Leu Ala Thr Glu  Cys Gly Gln 
    2270                 2275                 2280             


Gly Glu  Glu Lys Ser Glu Gly  Pro Leu Gly Ser Gln  Glu Ser Glu 
    2285                 2290                 2295             


Ser Cys  Gly Leu Arg Lys Glu  Glu Lys Glu Pro His  Ala Asp Lys 
    2300                 2305                 2310             


Asp Phe  Cys Gln Glu Lys Gln  Val Ala Tyr Cys Pro  Ser Gly Lys 
    2315                 2320                 2325             


Pro Glu  Gly Leu Asn Tyr Ala  Cys Leu Thr His Ser  Gly Tyr Gly 
    2330                 2335                 2340             


Asp Gly  Ser Asp 
    2345         


<210>  2735
<211>  607
<212>  PRT
<213>  Homo sapiens

<400>  2735

Met Glu Ala Pro Ala Ala Gly Leu Phe Leu Leu Leu Leu Leu Gly Thr 
1               5                   10                  15      


Trp Ala Pro Ala Pro Gly Ser Ala Ser Ser Glu Ala Pro Pro Leu Ile 
            20                  25                  30          


Asn Glu Asp Val Lys Arg Thr Val Asp Leu Ser Ser His Leu Ala Lys 
        35                  40                  45              


Val Thr Ala Glu Val Val Leu Ala His Leu Gly Gly Gly Ser Thr Ser 
    50                  55                  60                  


Arg Ala Thr Ser Phe Leu Leu Ala Leu Glu Pro Glu Leu Glu Ala Arg 
65                  70                  75                  80  


Leu Ala His Leu Gly Val Gln Val Lys Gly Glu Asp Glu Glu Glu Asn 
                85                  90                  95      


Asn Leu Glu Val Arg Glu Thr Lys Ile Lys Gly Lys Ser Gly Arg Phe 
            100                 105                 110         


Phe Thr Val Lys Leu Pro Val Ala Leu Asp Pro Gly Ala Lys Ile Ser 
        115                 120                 125             


Val Ile Val Glu Thr Val Tyr Thr His Val Leu His Pro Tyr Pro Thr 
    130                 135                 140                 


Gln Ile Thr Gln Ser Glu Lys Gln Phe Val Val Phe Glu Gly Asn His 
145                 150                 155                 160 


Tyr Phe Tyr Ser Pro Tyr Pro Thr Lys Thr Gln Thr Met Arg Val Lys 
                165                 170                 175     


Leu Ala Ser Arg Asn Val Glu Ser Tyr Thr Lys Leu Gly Asn Pro Thr 
            180                 185                 190         


Arg Ser Glu Asp Leu Leu Asp Tyr Gly Pro Phe Arg Asp Val Pro Ala 
        195                 200                 205             


Tyr Ser Gln Asp Thr Phe Lys Val His Tyr Glu Asn Asn Ser Pro Phe 
    210                 215                 220                 


Leu Thr Ile Thr Ser Met Thr Arg Val Ile Glu Val Ser His Trp Gly 
225                 230                 235                 240 


Asn Ile Ala Val Glu Glu Asn Val Asp Leu Lys His Thr Gly Ala Val 
                245                 250                 255     


Leu Lys Gly Pro Phe Ser Arg Tyr Asp Tyr Gln Arg Gln Pro Asp Ser 
            260                 265                 270         


Gly Ile Ser Ser Ile Arg Ser Phe Lys Thr Ile Leu Pro Ala Ala Ala 
        275                 280                 285             


Gln Asp Val Tyr Tyr Arg Asp Glu Ile Gly Asn Val Ser Thr Ser His 
    290                 295                 300                 


Leu Leu Ile Leu Asp Asp Ser Val Glu Met Glu Ile Arg Pro Arg Phe 
305                 310                 315                 320 


Pro Leu Phe Gly Gly Trp Lys Thr His Tyr Ile Val Gly Tyr Asn Leu 
                325                 330                 335     


Pro Ser Tyr Glu Tyr Leu Tyr Asn Leu Gly Asp Gln Tyr Ala Leu Lys 
            340                 345                 350         


Met Arg Phe Val Asp His Val Phe Asp Glu Gln Val Ile Asp Ser Leu 
        355                 360                 365             


Thr Val Lys Ile Ile Leu Pro Glu Gly Ala Lys Asn Ile Glu Ile Asp 
    370                 375                 380                 


Ser Pro Tyr Glu Ile Ser Arg Ala Pro Asp Glu Leu His Tyr Thr Tyr 
385                 390                 395                 400 


Leu Asp Thr Phe Gly Arg Pro Val Ile Val Ala Tyr Lys Lys Asn Leu 
                405                 410                 415     


Val Glu Gln His Ile Gln Asp Ile Val Val His Tyr Thr Phe Asn Lys 
            420                 425                 430         


Val Leu Met Leu Gln Glu Pro Leu Leu Val Val Ala Ala Phe Tyr Ile 
        435                 440                 445             


Leu Phe Phe Thr Val Ile Ile Tyr Val Arg Leu Asp Phe Ser Ile Thr 
    450                 455                 460                 


Lys Asp Pro Ala Ala Glu Ala Arg Met Lys Val Ala Cys Ile Thr Glu 
465                 470                 475                 480 


Gln Val Leu Thr Leu Val Asn Lys Arg Ile Gly Leu Tyr Arg His Phe 
                485                 490                 495     


Asp Glu Thr Val Asn Arg Tyr Lys Gln Ser Arg Asp Ile Ser Thr Leu 
            500                 505                 510         


Asn Ser Gly Lys Lys Ser Leu Glu Thr Glu His Lys Ala Leu Thr Ser 
        515                 520                 525             


Glu Ile Ala Leu Leu Gln Ser Arg Leu Lys Thr Glu Gly Ser Asp Leu 
    530                 535                 540                 


Cys Asp Arg Val Ser Glu Met Gln Lys Leu Asp Ala Gln Val Lys Glu 
545                 550                 555                 560 


Leu Val Leu Lys Ser Ala Val Glu Ala Glu Arg Leu Val Ala Gly Lys 
                565                 570                 575     


Leu Lys Lys Asp Thr Tyr Ile Glu Asn Glu Lys Leu Ile Ser Gly Lys 
            580                 585                 590         


Arg Gln Glu Leu Val Thr Lys Ile Asp His Ile Leu Asp Ala Leu 
        595                 600                 605         


<210>  2736
<211>  631
<212>  PRT
<213>  Homo sapiens

<400>  2736

Met Ala Pro Pro Gly Ser Ser Thr Val Phe Leu Leu Ala Leu Thr Ile 
1               5                   10                  15      


Ile Ala Ser Thr Trp Ala Leu Thr Pro Thr His Tyr Leu Thr Lys His 
            20                  25                  30          


Asp Val Glu Arg Leu Lys Ala Ser Leu Asp Arg Pro Phe Thr Asn Leu 
        35                  40                  45              


Glu Ser Ala Phe Tyr Ser Ile Val Gly Leu Ser Ser Leu Gly Ala Gln 
    50                  55                  60                  


Val Pro Asp Ala Lys Lys Ala Cys Thr Tyr Ile Arg Ser Asn Leu Asp 
65                  70                  75                  80  


Pro Ser Asn Val Asp Ser Leu Phe Tyr Ala Ala Gln Ala Ser Gln Ala 
                85                  90                  95      


Leu Ser Gly Cys Glu Ile Ser Ile Ser Asn Glu Thr Lys Asp Leu Leu 
            100                 105                 110         


Leu Ala Ala Val Ser Glu Asp Ser Ser Val Thr Gln Ile Tyr His Ala 
        115                 120                 125             


Val Ala Ala Leu Ser Gly Phe Gly Leu Pro Leu Ala Ser Gln Glu Ala 
    130                 135                 140                 


Leu Ser Ala Leu Thr Ala Arg Leu Ser Lys Glu Glu Thr Val Leu Ala 
145                 150                 155                 160 


Thr Val Gln Ala Leu Gln Thr Ala Ser His Leu Ser Gln Gln Ala Asp 
                165                 170                 175     


Leu Arg Ser Ile Val Glu Glu Ile Glu Asp Leu Val Ala Arg Leu Asp 
            180                 185                 190         


Glu Leu Gly Gly Val Tyr Leu Gln Phe Glu Glu Gly Leu Glu Thr Thr 
        195                 200                 205             


Ala Leu Phe Val Ala Ala Thr Tyr Lys Leu Met Asp His Val Gly Thr 
    210                 215                 220                 


Glu Pro Ser Ile Lys Glu Asp Gln Val Ile Gln Leu Met Asn Ala Ile 
225                 230                 235                 240 


Phe Ser Lys Lys Asn Phe Glu Ser Leu Ser Glu Ala Phe Ser Val Ala 
                245                 250                 255     


Ser Ala Ala Ala Val Leu Ser His Asn Arg Tyr His Val Pro Val Val 
            260                 265                 270         


Val Val Pro Glu Gly Ser Ala Ser Asp Thr His Glu Gln Ala Ile Leu 
        275                 280                 285             


Arg Leu Gln Val Thr Asn Val Leu Ser Gln Pro Leu Thr Gln Ala Thr 
    290                 295                 300                 


Val Lys Leu Glu His Ala Lys Ser Val Ala Ser Arg Ala Thr Val Leu 
305                 310                 315                 320 


Gln Lys Thr Ser Phe Thr Pro Val Gly Asp Val Phe Glu Leu Asn Phe 
                325                 330                 335     


Met Asn Val Lys Phe Ser Ser Gly Tyr Tyr Asp Phe Leu Val Glu Val 
            340                 345                 350         


Glu Gly Asp Asn Arg Tyr Ile Ala Asn Thr Val Glu Leu Arg Val Lys 
        355                 360                 365             


Ile Ser Thr Glu Val Gly Ile Thr Asn Val Asp Leu Ser Thr Val Asp 
    370                 375                 380                 


Lys Asp Gln Ser Ile Ala Pro Lys Thr Thr Arg Val Thr Tyr Pro Ala 
385                 390                 395                 400 


Lys Ala Lys Gly Thr Phe Ile Ala Asp Ser His Gln Asn Phe Ala Leu 
                405                 410                 415     


Phe Phe Gln Leu Val Asp Val Asn Thr Gly Ala Glu Leu Thr Pro His 
            420                 425                 430         


Gln Thr Phe Val Arg Leu His Asn Gln Lys Thr Gly Gln Glu Val Val 
        435                 440                 445             


Phe Val Ala Glu Pro Asp Asn Lys Asn Val Tyr Lys Phe Glu Leu Asp 
    450                 455                 460                 


Thr Ser Glu Arg Lys Ile Glu Phe Asp Ser Ala Ser Gly Thr Tyr Thr 
465                 470                 475                 480 


Leu Tyr Leu Ile Ile Gly Asp Ala Thr Leu Lys Asn Pro Ile Leu Trp 
                485                 490                 495     


Asn Val Ala Asp Val Val Ile Lys Phe Pro Glu Glu Glu Ala Pro Ser 
            500                 505                 510         


Thr Val Leu Ser Gln Asn Leu Phe Thr Pro Lys Gln Glu Ile Gln His 
        515                 520                 525             


Leu Phe Arg Glu Pro Glu Lys Arg Pro Pro Thr Val Val Ser Asn Thr 
    530                 535                 540                 


Phe Thr Ala Leu Ile Leu Ser Pro Leu Leu Leu Leu Phe Ala Leu Trp 
545                 550                 555                 560 


Ile Arg Ile Gly Ala Asn Val Ser Asn Phe Thr Phe Ala Pro Ser Thr 
                565                 570                 575     


Ile Ile Phe His Leu Gly His Ala Ala Met Leu Gly Leu Met Tyr Val 
            580                 585                 590         


Tyr Trp Thr Gln Leu Asn Met Phe Gln Thr Leu Lys Tyr Leu Ala Ile 
        595                 600                 605             


Leu Gly Ser Val Thr Phe Leu Ala Gly Asn Arg Met Leu Ala Gln Gln 
    610                 615                 620                 


Ala Val Lys Arg Thr Ala His 
625                 630     


<210>  2737
<211>  607
<212>  PRT
<213>  Homo sapiens

<400>  2737

Met Arg Gly Ala Ala Arg Leu Gly Arg Pro Gly Arg Ser Cys Leu Pro 
1               5                   10                  15      


Gly Ala Arg Gly Leu Arg Ala Pro Pro Pro Pro Pro Leu Leu Leu Leu 
            20                  25                  30          


Leu Ala Leu Leu Pro Leu Leu Pro Ala Pro Gly Ala Ala Ala Ala Pro 
        35                  40                  45              


Ala Pro Arg Pro Pro Glu Leu Gln Ser Ala Ser Ala Gly Pro Ser Val 
    50                  55                  60                  


Ser Leu Tyr Leu Ser Glu Asp Glu Val Arg Arg Leu Ile Gly Leu Asp 
65                  70                  75                  80  


Ala Glu Leu Tyr Tyr Val Arg Asn Asp Leu Ile Ser His Tyr Ala Leu 
                85                  90                  95      


Ser Phe Ser Leu Leu Val Pro Ser Glu Thr Asn Phe Leu His Phe Thr 
            100                 105                 110         


Trp His Ala Lys Ser Lys Val Glu Tyr Lys Leu Gly Phe Gln Val Asp 
        115                 120                 125             


Asn Val Leu Ala Met Asp Met Pro Gln Val Asn Ile Ser Val Gln Gly 
    130                 135                 140                 


Glu Val Pro Arg Thr Leu Ser Val Phe Arg Val Glu Leu Ser Cys Thr 
145                 150                 155                 160 


Gly Lys Val Asp Ser Glu Val Met Ile Leu Met Gln Leu Asn Leu Thr 
                165                 170                 175     


Val Asn Ser Ser Lys Asn Phe Thr Val Leu Asn Phe Lys Arg Arg Lys 
            180                 185                 190         


Met Cys Tyr Lys Lys Leu Glu Glu Val Lys Thr Ser Ala Leu Asp Lys 
        195                 200                 205             


Asn Thr Ser Arg Thr Ile Tyr Asp Pro Val His Ala Ala Pro Thr Thr 
    210                 215                 220                 


Ser Thr Arg Val Phe Tyr Ile Ser Val Gly Val Cys Cys Ala Val Ile 
225                 230                 235                 240 


Phe Leu Val Ala Ile Ile Leu Ala Val Leu His Leu His Ser Met Lys 
                245                 250                 255     


Arg Ile Glu Leu Asp Asp Ser Ile Ser Ala Ser Ser Ser Ser Gln Gly 
            260                 265                 270         


Leu Ser Gln Pro Ser Thr Gln Thr Thr Gln Tyr Leu Arg Ala Asp Thr 
        275                 280                 285             


Pro Asn Asn Ala Thr Pro Ile Thr Ser Tyr Pro Thr Leu Arg Ile Glu 
    290                 295                 300                 


Lys Asn Asp Leu Arg Ser Val Thr Leu Leu Glu Ala Lys Gly Lys Val 
305                 310                 315                 320 


Lys Asp Ile Ala Ile Ser Arg Glu Arg Ile Thr Leu Lys Asp Val Leu 
                325                 330                 335     


Gln Glu Gly Thr Phe Gly Arg Ile Phe His Gly Ile Leu Ile Asp Glu 
            340                 345                 350         


Lys Asp Pro Asn Lys Glu Lys Gln Ala Phe Val Lys Thr Val Lys Asp 
        355                 360                 365             


Gln Ala Ser Glu Ile Gln Val Thr Met Met Leu Thr Glu Ser Cys Lys 
    370                 375                 380                 


Leu Arg Gly Leu His His Arg Asn Leu Leu Pro Ile Thr His Val Cys 
385                 390                 395                 400 


Ile Glu Glu Gly Glu Lys Pro Met Val Ile Leu Pro Tyr Met Asn Trp 
                405                 410                 415     


Gly Asn Leu Lys Leu Phe Leu Arg Gln Cys Lys Leu Val Glu Ala Asn 
            420                 425                 430         


Asn Pro Gln Ala Ile Ser Gln Gln Asp Leu Val His Met Ala Ile Gln 
        435                 440                 445             


Ile Ala Cys Gly Met Ser Tyr Leu Ala Arg Arg Glu Val Ile His Lys 
    450                 455                 460                 


Asp Leu Ala Ala Arg Asn Cys Val Ile Asp Asp Thr Leu Gln Val Lys 
465                 470                 475                 480 


Ile Thr Asp Asn Ala Leu Ser Arg Asp Leu Phe Pro Met Asp Tyr His 
                485                 490                 495     


Cys Leu Gly Asp Asn Glu Asn Arg Pro Val Arg Trp Met Ala Leu Glu 
            500                 505                 510         


Ser Leu Val Asn Asn Glu Phe Ser Ser Ala Ser Asp Val Trp Ala Phe 
        515                 520                 525             


Gly Val Thr Leu Trp Glu Leu Met Thr Leu Gly Gln Thr Pro Tyr Val 
    530                 535                 540                 


Asp Ile Asp Pro Phe Glu Met Ala Ala Tyr Leu Lys Asp Gly Tyr Arg 
545                 550                 555                 560 


Ile Ala Gln Pro Ile Asn Cys Pro Asp Glu Leu Phe Ala Val Met Ala 
                565                 570                 575     


Cys Cys Trp Ala Leu Asp Pro Glu Glu Arg Pro Lys Phe Gln Gln Leu 
            580                 585                 590         


Val Gln Cys Leu Thr Glu Phe His Ala Ala Leu Gly Ala Tyr Val 
        595                 600                 605         


<210>  2738
<211>  831
<212>  PRT
<213>  Homo sapiens

<400>  2738

Met Glu Arg Pro Trp Gly Ala Ala Asp Gly Leu Ser Arg Trp Pro His 
1               5                   10                  15      


Gly Leu Gly Leu Leu Leu Leu Leu Gln Leu Leu Pro Pro Ser Thr Leu 
            20                  25                  30          


Ser Gln Asp Arg Leu Asp Ala Pro Pro Pro Pro Ala Ala Pro Leu Pro 
        35                  40                  45              


Arg Trp Ser Gly Pro Ile Gly Val Ser Trp Gly Leu Arg Ala Ala Ala 
    50                  55                  60                  


Ala Gly Gly Ala Phe Pro Arg Gly Gly Arg Trp Arg Arg Ser Ala Pro 
65                  70                  75                  80  


Gly Glu Asp Glu Glu Cys Gly Arg Val Arg Asp Phe Val Ala Lys Leu 
                85                  90                  95      


Ala Asn Asn Thr His Gln His Val Phe Asp Asp Leu Arg Gly Ser Val 
            100                 105                 110         


Ser Leu Ser Trp Val Gly Asp Ser Thr Gly Val Ile Leu Val Leu Thr 
        115                 120                 125             


Thr Phe His Val Pro Leu Val Ile Met Thr Phe Gly Gln Ser Lys Leu 
    130                 135                 140                 


Tyr Arg Ser Glu Asp Tyr Gly Lys Asn Phe Lys Asp Ile Thr Asp Leu 
145                 150                 155                 160 


Ile Asn Asn Thr Phe Ile Arg Thr Glu Phe Gly Met Ala Ile Gly Pro 
                165                 170                 175     


Glu Asn Ser Gly Lys Val Val Leu Thr Ala Glu Val Ser Gly Gly Ser 
            180                 185                 190         


Arg Gly Gly Arg Ile Phe Arg Ser Ser Asp Phe Ala Lys Asn Phe Val 
        195                 200                 205             


Gln Thr Asp Leu Pro Phe His Pro Leu Thr Gln Met Met Tyr Ser Pro 
    210                 215                 220                 


Gln Asn Ser Asp Tyr Leu Leu Ala Leu Ser Thr Glu Asn Gly Leu Trp 
225                 230                 235                 240 


Val Ser Lys Asn Phe Gly Gly Lys Trp Glu Glu Ile His Lys Ala Val 
                245                 250                 255     


Cys Leu Ala Lys Trp Gly Ser Asp Asn Thr Ile Phe Phe Thr Thr Tyr 
            260                 265                 270         


Ala Asn Gly Ser Cys Lys Ala Asp Leu Gly Ala Leu Glu Leu Trp Arg 
        275                 280                 285             


Thr Ser Asp Leu Gly Lys Ser Phe Lys Thr Ile Gly Val Lys Ile Tyr 
    290                 295                 300                 


Ser Phe Gly Leu Gly Gly Arg Phe Leu Phe Ala Ser Val Met Ala Asp 
305                 310                 315                 320 


Lys Asp Thr Thr Arg Arg Ile His Val Ser Thr Asp Gln Gly Asp Thr 
                325                 330                 335     


Trp Ser Met Ala Gln Leu Pro Ser Val Gly Gln Glu Gln Phe Tyr Ser 
            340                 345                 350         


Ile Leu Ala Ala Asn Asp Asp Met Val Phe Met His Val Asp Glu Pro 
        355                 360                 365             


Gly Asp Thr Gly Phe Gly Thr Ile Phe Thr Ser Asp Asp Arg Gly Ile 
    370                 375                 380                 


Val Tyr Ser Lys Ser Leu Asp Arg His Leu Tyr Thr Thr Thr Gly Gly 
385                 390                 395                 400 


Glu Thr Asp Phe Thr Asn Val Thr Ser Leu Arg Gly Val Tyr Ile Thr 
                405                 410                 415     


Ser Val Leu Ser Glu Asp Asn Ser Ile Gln Thr Met Ile Thr Phe Asp 
            420                 425                 430         


Gln Gly Gly Arg Trp Thr His Leu Arg Lys Pro Glu Asn Ser Glu Cys 
        435                 440                 445             


Asp Ala Thr Ala Lys Asn Lys Asn Glu Cys Ser Leu His Ile His Ala 
    450                 455                 460                 


Ser Tyr Ser Ile Ser Gln Lys Leu Asn Val Pro Met Ala Pro Leu Ser 
465                 470                 475                 480 


Glu Pro Asn Ala Val Gly Ile Val Ile Ala His Gly Ser Val Gly Asp 
                485                 490                 495     


Ala Ile Ser Val Met Val Pro Asp Val Tyr Ile Ser Asp Asp Gly Gly 
            500                 505                 510         


Tyr Ser Trp Thr Lys Met Leu Glu Gly Pro His Tyr Tyr Thr Ile Leu 
        515                 520                 525             


Asp Ser Gly Gly Ile Ile Val Ala Ile Glu His Ser Ser Arg Pro Ile 
    530                 535                 540                 


Asn Val Ile Lys Phe Ser Thr Asp Glu Gly Gln Cys Trp Gln Thr Tyr 
545                 550                 555                 560 


Thr Phe Thr Arg Asp Pro Ile Tyr Phe Thr Gly Leu Ala Ser Glu Pro 
                565                 570                 575     


Gly Ala Arg Ser Met Asn Ile Ser Ile Trp Gly Phe Thr Glu Ser Phe 
            580                 585                 590         


Leu Thr Ser Gln Trp Val Ser Tyr Thr Ile Asp Phe Lys Asp Ile Leu 
        595                 600                 605             


Glu Arg Asn Cys Glu Glu Lys Asp Tyr Thr Ile Trp Leu Ala His Ser 
    610                 615                 620                 


Thr Asp Pro Glu Asp Tyr Glu Asp Gly Cys Ile Leu Gly Tyr Lys Glu 
625                 630                 635                 640 


Gln Phe Leu Arg Leu Arg Lys Ser Ser Val Cys Gln Asn Gly Arg Asp 
                645                 650                 655     


Tyr Val Val Thr Lys Gln Pro Ser Ile Cys Leu Cys Ser Leu Glu Asp 
            660                 665                 670         


Phe Leu Cys Asp Phe Gly Tyr Tyr Arg Pro Glu Asn Asp Ser Lys Cys 
        675                 680                 685             


Val Glu Gln Pro Glu Leu Lys Gly His Asp Leu Glu Phe Cys Leu Tyr 
    690                 695                 700                 


Gly Arg Glu Glu His Leu Thr Thr Asn Gly Tyr Arg Lys Ile Pro Gly 
705                 710                 715                 720 


Asp Lys Cys Gln Gly Gly Val Asn Pro Val Arg Glu Val Lys Asp Leu 
                725                 730                 735     


Lys Lys Lys Cys Thr Ser Asn Phe Leu Ser Pro Glu Lys Gln Asn Ser 
            740                 745                 750         


Lys Ser Asn Ser Val Pro Ile Ile Leu Ala Ile Val Gly Leu Met Leu 
        755                 760                 765             


Val Thr Val Val Ala Gly Val Leu Ile Val Lys Lys Tyr Val Cys Gly 
    770                 775                 780                 


Gly Arg Phe Leu Val His Arg Tyr Ser Val Leu Gln Gln His Ala Glu 
785                 790                 795                 800 


Ala Asn Gly Val Asp Gly Val Asp Ala Leu Asp Thr Ala Ser His Thr 
                805                 810                 815     


Asn Lys Ser Gly Tyr His Asp Asp Ser Asp Glu Asp Leu Leu Glu 
            820                 825                 830     


<210>  2739
<211>  1682
<212>  PRT
<213>  Homo sapiens

<400>  2739

Met Leu Ala Ser Pro Glu Pro Lys Gly Leu Val Pro Phe Thr Lys Glu 
1               5                   10                  15      


Ser Phe Glu Leu Ile Lys Gln His Ile Ala Lys Thr His Asn Glu Asp 
            20                  25                  30          


His Glu Glu Glu Asp Leu Lys Pro Thr Pro Asp Leu Glu Val Gly Lys 
        35                  40                  45              


Lys Leu Pro Phe Ile Tyr Gly Asn Leu Ser Gln Gly Met Val Ser Glu 
    50                  55                  60                  


Pro Leu Glu Asp Val Asp Pro Tyr Tyr Tyr Lys Lys Lys Asn Thr Phe 
65                  70                  75                  80  


Ile Val Leu Asn Lys Asn Arg Thr Ile Phe Arg Phe Asn Ala Ala Ser 
                85                  90                  95      


Ile Leu Cys Thr Leu Ser Pro Phe Asn Cys Ile Arg Arg Thr Thr Ile 
            100                 105                 110         


Lys Val Leu Val His Pro Phe Phe Gln Leu Phe Ile Leu Ile Ser Val 
        115                 120                 125             


Leu Ile Asp Cys Val Phe Met Ser Leu Thr Asn Leu Pro Lys Trp Arg 
    130                 135                 140                 


Pro Val Leu Glu Asn Thr Leu Leu Gly Ile Tyr Thr Phe Glu Ile Leu 
145                 150                 155                 160 


Val Lys Leu Phe Ala Arg Gly Val Trp Ala Gly Ser Phe Ser Phe Leu 
                165                 170                 175     


Gly Asp Pro Trp Asn Trp Leu Asp Phe Ser Val Thr Val Phe Glu Val 
            180                 185                 190         


Ile Ile Arg Tyr Ser Pro Leu Asp Phe Ile Pro Thr Leu Gln Thr Ala 
        195                 200                 205             


Arg Thr Leu Arg Ile Leu Lys Ile Ile Pro Leu Asn Gln Gly Leu Lys 
    210                 215                 220                 


Ser Leu Val Gly Val Leu Ile His Cys Leu Lys Gln Leu Ile Gly Val 
225                 230                 235                 240 


Ile Ile Leu Thr Leu Phe Phe Leu Ser Ile Phe Ser Leu Ile Gly Met 
                245                 250                 255     


Gly Leu Phe Met Gly Asn Leu Lys His Lys Cys Phe Arg Trp Pro Gln 
            260                 265                 270         


Glu Asn Glu Asn Glu Thr Leu His Asn Arg Thr Gly Asn Pro Tyr Tyr 
        275                 280                 285             


Ile Arg Glu Thr Glu Asn Phe Tyr Tyr Leu Glu Gly Glu Arg Tyr Ala 
    290                 295                 300                 


Leu Leu Cys Gly Asn Arg Thr Asp Ala Gly Gln Cys Pro Glu Gly Tyr 
305                 310                 315                 320 


Val Cys Val Lys Ala Gly Ile Asn Pro Asp Gln Gly Phe Thr Asn Phe 
                325                 330                 335     


Asp Ser Phe Gly Trp Ala Leu Phe Ala Leu Phe Arg Leu Met Ala Gln 
            340                 345                 350         


Asp Tyr Pro Glu Val Leu Tyr His Gln Ile Leu Tyr Ala Ser Gly Lys 
        355                 360                 365             


Val Tyr Met Ile Phe Phe Val Val Val Ser Phe Leu Phe Ser Phe Tyr 
    370                 375                 380                 


Met Ala Ser Leu Phe Leu Gly Ile Leu Ala Met Ala Tyr Glu Glu Glu 
385                 390                 395                 400 


Lys Gln Arg Val Gly Glu Ile Ser Lys Lys Ile Glu Pro Lys Phe Gln 
                405                 410                 415     


Gln Thr Gly Lys Glu Leu Gln Glu Gly Asn Glu Thr Asp Glu Ala Lys 
            420                 425                 430         


Thr Ile Gln Ile Glu Met Lys Lys Arg Ser Pro Ile Ser Thr Asp Thr 
        435                 440                 445             


Ser Leu Asp Val Leu Glu Asp Ala Thr Leu Arg His Lys Glu Glu Leu 
    450                 455                 460                 


Glu Lys Ser Lys Lys Ile Cys Pro Leu Tyr Trp Tyr Lys Phe Ala Lys 
465                 470                 475                 480 


Thr Phe Leu Ile Trp Asn Cys Ser Pro Cys Trp Leu Lys Leu Lys Glu 
                485                 490                 495     


Phe Val His Arg Ile Ile Met Ala Pro Phe Thr Asp Leu Phe Leu Ile 
            500                 505                 510         


Ile Cys Ile Ile Leu Asn Val Cys Phe Leu Thr Leu Glu His Tyr Pro 
        515                 520                 525             


Met Ser Lys Gln Thr Asn Thr Leu Leu Asn Ile Gly Asn Leu Val Phe 
    530                 535                 540                 


Ile Gly Ile Phe Thr Ala Glu Met Ile Phe Lys Ile Ile Ala Met His 
545                 550                 555                 560 


Pro Tyr Gly Tyr Phe Gln Val Gly Trp Asn Ile Phe Asp Ser Met Ile 
                565                 570                 575     


Val Phe His Gly Leu Ile Glu Leu Cys Leu Ala Asn Val Ala Gly Met 
            580                 585                 590         


Ala Leu Leu Arg Leu Phe Arg Met Leu Arg Ile Phe Lys Leu Gly Lys 
        595                 600                 605             


Tyr Trp Pro Thr Phe Gln Ile Leu Met Trp Ser Leu Ser Asn Ser Trp 
    610                 615                 620                 


Val Ala Leu Lys Asp Leu Val Leu Leu Leu Phe Thr Phe Ile Phe Phe 
625                 630                 635                 640 


Ser Ala Ala Phe Gly Met Lys Leu Phe Gly Lys Asn Tyr Glu Glu Phe 
                645                 650                 655     


Val Cys His Ile Asp Lys Asp Cys Gln Leu Pro Arg Trp His Met His 
            660                 665                 670         


Asp Phe Phe His Ser Phe Leu Asn Val Phe Arg Ile Leu Cys Gly Glu 
        675                 680                 685             


Trp Val Glu Thr Leu Trp Asp Cys Met Glu Val Ala Gly Gln Ser Trp 
    690                 695                 700                 


Cys Ile Pro Phe Tyr Leu Met Val Ile Leu Ile Gly Asn Leu Leu Val 
705                 710                 715                 720 


Leu Tyr Leu Phe Leu Ala Leu Val Ser Ser Phe Ser Ser Cys Lys Asp 
                725                 730                 735     


Val Thr Ala Glu Glu Asn Asn Glu Ala Lys Asn Leu Gln Leu Ala Val 
            740                 745                 750         


Ala Arg Ile Lys Lys Gly Ile Asn Tyr Val Leu Leu Lys Ile Leu Cys 
        755                 760                 765             


Lys Thr Gln Asn Val Pro Lys Asp Thr Met Asp His Val Asn Glu Val 
    770                 775                 780                 


Tyr Val Lys Glu Asp Ile Ser Asp His Thr Leu Ser Glu Leu Ser Asn 
785                 790                 795                 800 


Thr Gln Asp Phe Leu Lys Asp Lys Glu Lys Ser Ser Gly Thr Glu Lys 
                805                 810                 815     


Asn Ala Thr Glu Asn Glu Ser Gln Ser Leu Ile Pro Ser Pro Ser Val 
            820                 825                 830         


Ser Glu Thr Val Pro Ile Ala Ser Gly Glu Ser Asp Ile Glu Asn Leu 
        835                 840                 845             


Asp Asn Lys Glu Ile Gln Ser Lys Ser Gly Asp Gly Gly Ser Lys Glu 
    850                 855                 860                 


Lys Ile Lys Gln Ser Ser Ser Ser Glu Cys Ser Thr Val Asp Ile Ala 
865                 870                 875                 880 


Ile Ser Glu Glu Glu Glu Met Phe Tyr Gly Gly Glu Arg Ser Lys His 
                885                 890                 895     


Leu Lys Asn Gly Cys Arg Arg Gly Ser Ser Leu Gly Gln Ile Ser Gly 
            900                 905                 910         


Ala Ser Lys Lys Gly Lys Ile Trp Gln Asn Ile Arg Lys Thr Cys Cys 
        915                 920                 925             


Lys Ile Val Glu Asn Asn Trp Phe Lys Cys Phe Ile Gly Leu Val Thr 
    930                 935                 940                 


Leu Leu Ser Thr Gly Thr Leu Ala Phe Glu Asp Ile Tyr Met Asp Gln 
945                 950                 955                 960 


Arg Lys Thr Ile Lys Ile Leu Leu Glu Tyr Ala Asp Met Ile Phe Thr 
                965                 970                 975     


Tyr Ile Phe Ile Leu Glu Met Leu Leu Lys Trp Met Ala Tyr Gly Phe 
            980                 985                 990         


Lys Ala Tyr Phe Ser Asn Gly Trp  Tyr Arg Leu Asp Phe  Val Val Val 
        995                 1000                 1005             


Ile Val  Phe Cys Leu Ser Leu  Ile Gly Lys Thr Arg  Glu Glu Leu 
    1010                 1015                 1020             


Lys Pro  Leu Ile Ser Met Lys  Phe Leu Arg Pro Leu  Arg Val Leu 
    1025                 1030                 1035             


Ser Gln  Phe Glu Arg Met Lys  Val Val Val Arg Ala  Leu Ile Lys 
    1040                 1045                 1050             


Thr Thr  Leu Pro Thr Leu Asn  Val Phe Leu Val Cys  Leu Met Ile 
    1055                 1060                 1065             


Trp Leu  Ile Phe Ser Ile Met  Gly Val Asp Leu Phe  Ala Gly Arg 
    1070                 1075                 1080             


Phe Tyr  Glu Cys Ile Asp Pro  Thr Ser Gly Glu Arg  Phe Pro Ser 
    1085                 1090                 1095             


Ser Glu  Val Met Asn Lys Ser  Arg Cys Glu Ser Leu  Leu Phe Asn 
    1100                 1105                 1110             


Glu Ser  Met Leu Trp Glu Asn  Ala Lys Met Asn Phe  Asp Asn Val 
    1115                 1120                 1125             


Gly Asn  Gly Phe Leu Ser Leu  Leu Gln Val Ala Thr  Phe Asn Gly 
    1130                 1135                 1140             


Trp Ile  Thr Ile Met Asn Ser  Ala Ile Asp Ser Val  Ala Val Asn 
    1145                 1150                 1155             


Ile Gln  Pro His Phe Glu Val  Asn Ile Tyr Met Tyr  Cys Tyr Phe 
    1160                 1165                 1170             


Ile Asn  Phe Ile Ile Phe Gly  Val Phe Leu Pro Leu  Ser Met Leu 
    1175                 1180                 1185             


Ile Thr  Val Ile Ile Asp Asn  Phe Asn Lys His Lys  Ile Lys Leu 
    1190                 1195                 1200             


Gly Gly  Ser Asn Ile Phe Ile  Thr Val Lys Gln Arg  Lys Gln Tyr 
    1205                 1210                 1215             


Arg Arg  Leu Lys Lys Leu Met  Tyr Glu Asp Ser Gln  Arg Pro Val 
    1220                 1225                 1230             


Pro Arg  Pro Leu Asn Lys Leu  Gln Gly Phe Ile Phe  Asp Val Val 
    1235                 1240                 1245             


Thr Ser  Gln Ala Phe Asn Val  Ile Val Met Val Leu  Ile Cys Phe 
    1250                 1255                 1260             


Gln Ala  Ile Ala Met Met Ile  Asp Thr Asp Val Gln  Ser Leu Gln 
    1265                 1270                 1275             


Met Ser  Ile Ala Leu Tyr Trp  Ile Asn Ser Ile Phe  Val Met Leu 
    1280                 1285                 1290             


Tyr Thr  Met Glu Cys Ile Leu  Lys Leu Ile Ala Phe  Arg Cys Phe 
    1295                 1300                 1305             


Tyr Phe  Thr Ile Ala Trp Asn  Ile Phe Asp Phe Met  Val Val Ile 
    1310                 1315                 1320             


Phe Ser  Ile Thr Gly Leu Cys  Leu Pro Met Thr Val  Gly Ser Tyr 
    1325                 1330                 1335             


Leu Val  Pro Pro Ser Leu Val  Gln Leu Ile Leu Leu  Ser Arg Ile 
    1340                 1345                 1350             


Ile His  Met Leu Arg Leu Gly  Lys Gly Pro Lys Val  Phe His Asn 
    1355                 1360                 1365             


Leu Met  Leu Pro Leu Met Leu  Ser Leu Pro Ala Leu  Leu Asn Ile 
    1370                 1375                 1380             


Ile Leu  Leu Ile Phe Leu Val  Met Phe Ile Tyr Ala  Val Phe Gly 
    1385                 1390                 1395             


Met Tyr  Asn Phe Ala Tyr Val  Lys Lys Glu Ala Gly  Ile Asn Asp 
    1400                 1405                 1410             


Val Ser  Asn Phe Glu Thr Phe  Gly Asn Ser Met Leu  Cys Leu Phe 
    1415                 1420                 1425             


Gln Val  Ala Ile Phe Ala Gly  Trp Asp Gly Met Leu  Asp Ala Ile 
    1430                 1435                 1440             


Phe Asn  Ser Lys Trp Ser Asp  Cys Asp Pro Asp Lys  Ile Asn Pro 
    1445                 1450                 1455             


Gly Thr  Gln Val Arg Gly Asp  Cys Gly Asn Pro Ser  Val Gly Ile 
    1460                 1465                 1470             


Phe Tyr  Phe Val Ser Tyr Ile  Leu Ile Ser Trp Leu  Ile Ile Val 
    1475                 1480                 1485             


Asn Met  Tyr Ile Val Val Val  Met Glu Phe Leu Asn  Ile Ala Ser 
    1490                 1495                 1500             


Lys Lys  Lys Asn Lys Thr Leu  Ser Glu Asp Asp Phe  Arg Lys Phe 
    1505                 1510                 1515             


Phe Gln  Val Trp Lys Arg Phe  Asp Pro Asp Arg Thr  Gln Tyr Ile 
    1520                 1525                 1530             


Asp Ser  Ser Lys Leu Ser Asp  Phe Ala Ala Ala Leu  Asp Pro Pro 
    1535                 1540                 1545             


Leu Phe  Met Ala Lys Pro Asn  Lys Gly Gln Leu Ile  Ala Leu Asp 
    1550                 1555                 1560             


Leu Pro  Met Ala Val Gly Asp  Arg Ile His Cys Leu  Asp Ile Leu 
    1565                 1570                 1575             


Leu Ala  Phe Thr Lys Arg Val  Met Gly Gln Asp Val  Arg Met Glu 
    1580                 1585                 1590             


Lys Val  Val Ser Glu Ile Glu  Ser Gly Phe Leu Leu  Ala Asn Pro 
    1595                 1600                 1605             


Phe Lys  Ile Thr Cys Glu Pro  Ile Thr Thr Thr Leu  Lys Arg Lys 
    1610                 1615                 1620             


Gln Glu  Ala Val Ser Ala Thr  Ile Ile Gln Arg Ala  Tyr Lys Asn 
    1625                 1630                 1635             


Tyr Arg  Leu Arg Arg Asn Asp  Lys Asn Thr Ser Asp  Ile His Met 
    1640                 1645                 1650             


Ile Asp  Gly Asp Arg Asp Val  His Ala Thr Lys Glu  Gly Ala Tyr 
    1655                 1660                 1665             


Phe Asp  Lys Ala Lys Glu Lys  Ser Pro Ile Gln Ser  Gln Ile 
    1670                 1675                 1680         


<210>  2740
<211>  1977
<212>  PRT
<213>  Homo sapiens

<400>  2740

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu Ser 
        275                 280                 285             


Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr 
    290                 295                 300                 


Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
305                 310                 315                 320 


Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys Ile Gly Arg Asn 
                325                 330                 335     


Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
            340                 345                 350         


Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
        355                 360                 365             


Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
    370                 375                 380                 


Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
385                 390                 395                 400 


Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                405                 410                 415     


Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 
            420                 425                 430         


Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr 
        435                 440                 445             


Ser Ile Arg Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 
    450                 455                 460                 


Thr Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
465                 470                 475                 480 


Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp 
                485                 490                 495     


Ala Glu Lys Leu Ser Lys Ser Glu Ser Glu Asp Ser Ile Arg Arg Lys 
            500                 505                 510         


Ser Phe His Leu Gly Val Glu Gly His Arg Arg Ala His Glu Lys Arg 
        515                 520                 525             


Leu Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe 
    530                 535                 540                 


Ser Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg 
545                 550                 555                 560 


Gly Arg Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser 
                565                 570                 575     


Ile Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His 
            580                 585                 590         


Arg Pro Gln Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser 
        595                 600                 605             


Pro Pro Met Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys 
    610                 615                 620                 


Asn Gly Val Val Ser Leu Val Asp Gly Arg Ser Ala Leu Met Leu Pro 
625                 630                 635                 640 


Asn Gly Gln Leu Leu Pro Glu Gly Thr Thr Asn Gln Ile His Lys Lys 
                645                 650                 655     


Arg Arg Cys Ser Ser Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro 
            660                 665                 670         


Asn Leu Arg Gln Arg Ala Met Ser Arg Ala Ser Ile Leu Thr Asn Thr 
        675                 680                 685             


Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr 
    690                 695                 700                 


Arg Phe Ala His Lys Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile 
705                 710                 715                 720 


Lys Phe Lys Lys Cys Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp 
                725                 730                 735     


Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met 
            740                 745                 750         


Glu His His Pro Met Thr Glu Glu Phe Lys Asn Val Leu Ala Ile Gly 
        755                 760                 765             


Asn Leu Val Phe Thr Gly Ile Phe Ala Ala Glu Met Val Leu Lys Leu 
    770                 775                 780                 


Ile Ala Met Asp Pro Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe 
785                 790                 795                 800 


Asp Ser Leu Ile Val Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp 
                805                 810                 815     


Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
            820                 825                 830         


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile 
        835                 840                 845             


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
    850                 855                 860                 


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser 
865                 870                 875                 880 


Tyr Lys Glu Cys Val Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg 
                885                 890                 895     


Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val Phe Arg Val 
            900                 905                 910         


Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala 
        915                 920                 925             


Gly Gln Ala Met Cys Leu Ile Val Tyr Met Met Val Met Val Ile Gly 
    930                 935                 940                 


Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe 
945                 950                 955                 960 


Ser Ser Asp Asn Leu Thr Ala Ile Glu Glu Asp Pro Asp Ala Asn Asn 
                965                 970                 975     


Leu Gln Ile Ala Val Thr Arg Ile Lys Lys Gly Ile Asn Tyr Val Lys 
            980                 985                 990         


Gln Thr Leu Arg Glu Phe Ile Leu  Lys Ala Phe Ser Lys  Lys Pro Lys 
        995                 1000                 1005             


Ile Ser  Arg Glu Ile Arg Gln  Ala Glu Asp Leu Asn  Thr Lys Lys 
    1010                 1015                 1020             


Glu Asn  Tyr Ile Ser Asn His  Thr Leu Ala Glu Met  Ser Lys Gly 
    1025                 1030                 1035             


His Asn  Phe Leu Lys Glu Lys  Asp Lys Ile Ser Gly  Phe Gly Ser 
    1040                 1045                 1050             


Ser Val  Asp Lys His Leu Met  Glu Asp Ser Asp Gly  Gln Ser Phe 
    1055                 1060                 1065             


Ile His  Asn Pro Ser Leu Thr  Val Thr Val Pro Ile  Ala Pro Gly 
    1070                 1075                 1080             


Glu Ser  Asp Leu Glu Asn Met  Asn Ala Glu Glu Leu  Ser Ser Asp 
    1085                 1090                 1095             


Ser Asp  Ser Glu Tyr Ser Lys  Val Arg Leu Asn Arg  Ser Ser Ser 
    1100                 1105                 1110             


Ser Glu  Cys Ser Thr Val Asp  Asn Pro Leu Pro Gly  Glu Gly Glu 
    1115                 1120                 1125             


Glu Ala  Glu Ala Glu Pro Met  Asn Ser Asp Glu Pro  Glu Ala Cys 
    1130                 1135                 1140             


Phe Thr  Asp Gly Cys Val Arg  Arg Phe Ser Cys Cys  Gln Val Asn 
    1145                 1150                 1155             


Ile Glu  Ser Gly Lys Gly Lys  Ile Trp Trp Asn Ile  Arg Lys Thr 
    1160                 1165                 1170             


Cys Tyr  Lys Ile Val Glu His  Ser Trp Phe Glu Ser  Phe Ile Val 
    1175                 1180                 1185             


Leu Met  Ile Leu Leu Ser Ser  Gly Ala Leu Ala Phe  Glu Asp Ile 
    1190                 1195                 1200             


Tyr Ile  Glu Arg Lys Lys Thr  Ile Lys Ile Ile Leu  Glu Tyr Ala 
    1205                 1210                 1215             


Asp Lys  Ile Phe Thr Tyr Ile  Phe Ile Leu Glu Met  Leu Leu Lys 
    1220                 1225                 1230             


Trp Ile  Ala Tyr Gly Tyr Lys  Thr Tyr Phe Thr Asn  Ala Trp Cys 
    1235                 1240                 1245             


Trp Leu  Asp Phe Leu Ile Val  Asp Val Ser Leu Val  Thr Leu Val 
    1250                 1255                 1260             


Ala Asn  Thr Leu Gly Tyr Ser  Asp Leu Gly Pro Ile  Lys Ser Leu 
    1265                 1270                 1275             


Arg Thr  Leu Arg Ala Leu Arg  Pro Leu Arg Ala Leu  Ser Arg Phe 
    1280                 1285                 1290             


Glu Gly  Met Arg Val Val Val  Asn Ala Leu Ile Gly  Ala Ile Pro 
    1295                 1300                 1305             


Ser Ile  Met Asn Val Leu Leu  Val Cys Leu Ile Phe  Trp Leu Ile 
    1310                 1315                 1320             


Phe Ser  Ile Met Gly Val Asn  Leu Phe Ala Gly Lys  Phe Tyr Glu 
    1325                 1330                 1335             


Cys Ile  Asn Thr Thr Asp Gly  Ser Arg Phe Pro Ala  Ser Gln Val 
    1340                 1345                 1350             


Pro Asn  Arg Ser Glu Cys Phe  Ala Leu Met Asn Val  Ser Gln Asn 
    1355                 1360                 1365             


Val Arg  Trp Lys Asn Leu Lys  Val Asn Phe Asp Asn  Val Gly Leu 
    1370                 1375                 1380             


Gly Tyr  Leu Ser Leu Leu Gln  Val Ala Thr Phe Lys  Gly Trp Thr 
    1385                 1390                 1395             


Ile Ile  Met Tyr Ala Ala Val  Asp Ser Val Asn Val  Asp Lys Gln 
    1400                 1405                 1410             


Pro Lys  Tyr Glu Tyr Ser Leu  Tyr Met Tyr Ile Tyr  Phe Val Val 
    1415                 1420                 1425             


Phe Ile  Ile Phe Gly Ser Phe  Phe Thr Leu Asn Leu  Phe Ile Gly 
    1430                 1435                 1440             


Val Ile  Ile Asp Asn Phe Asn  Gln Gln Lys Lys Lys  Leu Gly Gly 
    1445                 1450                 1455             


Gln Asp  Ile Phe Met Thr Glu  Glu Gln Lys Lys Tyr  Tyr Asn Ala 
    1460                 1465                 1470             


Met Lys  Lys Leu Gly Ser Lys  Lys Pro Gln Lys Pro  Ile Pro Arg 
    1475                 1480                 1485             


Pro Gly  Asn Lys Ile Gln Gly  Cys Ile Phe Asp Leu  Val Thr Asn 
    1490                 1495                 1500             


Gln Ala  Phe Asp Ile Ser Ile  Met Val Leu Ile Cys  Leu Asn Met 
    1505                 1510                 1515             


Val Thr  Met Met Val Glu Lys  Glu Gly Gln Ser Gln  His Met Thr 
    1520                 1525                 1530             


Glu Val  Leu Tyr Trp Ile Asn  Val Val Phe Ile Ile  Leu Phe Thr 
    1535                 1540                 1545             


Gly Glu  Cys Val Leu Lys Leu  Ile Ser Leu Arg His  Tyr Tyr Phe 
    1550                 1555                 1560             


Thr Val  Gly Trp Asn Ile Phe  Asp Phe Val Val Val  Ile Ile Ser 
    1565                 1570                 1575             


Ile Val  Gly Met Phe Leu Ala  Asp Leu Ile Glu Thr  Tyr Phe Val 
    1580                 1585                 1590             


Ser Pro  Thr Leu Phe Arg Val  Ile Arg Leu Ala Arg  Ile Gly Arg 
    1595                 1600                 1605             


Ile Leu  Arg Leu Val Lys Gly  Ala Lys Gly Ile Arg  Thr Leu Leu 
    1610                 1615                 1620             


Phe Ala  Leu Met Met Ser Leu  Pro Ala Leu Phe Asn  Ile Gly Leu 
    1625                 1630                 1635             


Leu Leu  Phe Leu Val Met Phe  Ile Tyr Ala Ile Phe  Gly Met Ser 
    1640                 1645                 1650             


Asn Phe  Ala Tyr Val Lys Lys  Glu Asp Gly Ile Asn  Asp Met Phe 
    1655                 1660                 1665             


Asn Phe  Glu Thr Phe Gly Asn  Ser Met Ile Cys Leu  Phe Gln Ile 
    1670                 1675                 1680             


Thr Thr  Ser Ala Gly Trp Asp  Gly Leu Leu Ala Pro  Ile Leu Asn 
    1685                 1690                 1695             


Ser Lys  Pro Pro Asp Cys Asp  Pro Lys Lys Val His  Pro Gly Ser 
    1700                 1705                 1710             


Ser Val  Glu Gly Asp Cys Gly  Asn Pro Ser Val Gly  Ile Phe Tyr 
    1715                 1720                 1725             


Phe Val  Ser Tyr Ile Ile Ile  Ser Phe Leu Val Val  Val Asn Met 
    1730                 1735                 1740             


Tyr Ile  Ala Val Ile Leu Glu  Asn Phe Ser Val Ala  Thr Glu Glu 
    1745                 1750                 1755             


Ser Thr  Glu Pro Leu Ser Glu  Asp Asp Phe Glu Met  Phe Tyr Glu 
    1760                 1765                 1770             


Val Trp  Glu Lys Phe Asp Pro  Asp Ala Thr Gln Phe  Ile Glu Phe 
    1775                 1780                 1785             


Ser Lys  Leu Ser Asp Phe Ala  Ala Ala Leu Asp Pro  Pro Leu Leu 
    1790                 1795                 1800             


Ile Ala  Lys Pro Asn Lys Val  Gln Leu Ile Ala Met  Asp Leu Pro 
    1805                 1810                 1815             


Met Val  Ser Gly Asp Arg Ile  His Cys Leu Asp Ile  Leu Phe Ala 
    1820                 1825                 1830             


Phe Thr  Lys Arg Val Leu Gly  Glu Ser Gly Glu Met  Asp Ser Leu 
    1835                 1840                 1845             


Arg Ser  Gln Met Glu Glu Arg  Phe Met Ser Ala Asn  Pro Ser Lys 
    1850                 1855                 1860             


Val Ser  Tyr Glu Pro Ile Thr  Thr Thr Leu Lys Arg  Lys Gln Glu 
    1865                 1870                 1875             


Asp Val  Ser Ala Thr Val Ile  Gln Arg Ala Tyr Arg  Arg Tyr Arg 
    1880                 1885                 1890             


Leu Arg  Gln Asn Val Lys Asn  Ile Ser Ser Ile Tyr  Ile Lys Asp 
    1895                 1900                 1905             


Gly Asp  Arg Asp Asp Asp Leu  Leu Asn Lys Lys Asp  Met Ala Phe 
    1910                 1915                 1920             


Asp Asn  Val Asn Glu Asn Ser  Ser Pro Glu Lys Thr  Asp Ala Thr 
    1925                 1930                 1935             


Ser Ser  Thr Thr Ser Pro Pro  Ser Tyr Asp Ser Val  Thr Lys Pro 
    1940                 1945                 1950             


Asp Lys  Glu Lys Tyr Glu Gln  Asp Arg Thr Glu Lys  Glu Asp Lys 
    1955                 1960                 1965             


Gly Lys  Asp Ser Lys Glu Ser  Lys Lys 
    1970                 1975         


<210>  2741
<211>  802
<212>  PRT
<213>  Homo sapiens

<400>  2741

Met Arg Ala Val Leu Ser Gln Lys Thr Thr Pro Leu Pro Arg Tyr Leu 
1               5                   10                  15      


Trp Pro Gly His Leu Ser Gly Pro Arg Arg Leu Thr Trp Ser Trp Cys 
            20                  25                  30          


Ser Asp His Arg Thr Pro Thr Cys Arg Glu Leu Gly Ser Pro His Pro 
        35                  40                  45              


Thr Pro Cys Thr Gly Pro Ala Arg Gly Trp Pro Arg Arg Gly Gly Gly 
    50                  55                  60                  


Pro Cys Gly Phe Thr Ser Ala Gly His Val Leu Cys Gly Tyr Pro Leu 
65                  70                  75                  80  


Cys Leu Leu Ser Gly Pro Ile Gln Gly Cys Gly Thr Gly Leu Gly Asp 
                85                  90                  95      


Ser Ser Met Ala Phe Leu Ser Arg Thr Ser Pro Val Ala Ala Ala Ser 
            100                 105                 110         


Phe Gln Ser Arg Gln Glu Ala Arg Gly Ser Ile Leu Leu Gln Ser Cys 
        115                 120                 125             


Gln Leu Pro Pro Gln Trp Leu Ser Thr Glu Ala Trp Thr Gly Glu Trp 
    130                 135                 140                 


Lys Gln Pro His Gly Gly Ala Leu Thr Ser Arg Ser Pro Gly Pro Val 
145                 150                 155                 160 


Ala Pro Gln Arg Pro Cys His Leu Lys Gly Trp Gln His Arg Pro Thr 
                165                 170                 175     


Gln His Asn Ala Ala Cys Lys Gln Gly Gln Ala Ala Ala Gln Thr Pro 
            180                 185                 190         


Pro Arg Pro Gly Pro Pro Ser Ala Pro Pro Pro Pro Pro Lys Glu Gly 
        195                 200                 205             


His Gln Glu Gly Leu Val Glu Leu Pro Ala Ser Phe Arg Glu Leu Leu 
    210                 215                 220                 


Thr Phe Phe Cys Thr Asn Ala Thr Ile His Gly Ala Ile Arg Leu Val 
225                 230                 235                 240 


Cys Ser Arg Gly Asn Arg Leu Lys Thr Thr Ser Trp Gly Leu Leu Ser 
                245                 250                 255     


Leu Gly Ala Leu Val Ala Leu Cys Trp Gln Leu Gly Leu Leu Phe Glu 
            260                 265                 270         


Arg His Trp His Arg Pro Val Leu Met Ala Val Ser Val His Ser Glu 
        275                 280                 285             


Arg Lys Leu Leu Pro Leu Val Thr Leu Cys Asp Gly Asn Pro Arg Arg 
    290                 295                 300                 


Pro Ser Pro Val Leu Arg His Leu Glu Leu Leu Asp Glu Phe Ala Arg 
305                 310                 315                 320 


Glu Asn Ile Asp Ser Leu Tyr Asn Val Asn Leu Ser Lys Gly Arg Ala 
                325                 330                 335     


Ala Leu Ser Ala Thr Val Pro Arg His Glu Pro Pro Phe His Leu Asp 
            340                 345                 350         


Arg Glu Ile Arg Leu Gln Arg Leu Ser His Ser Gly Ser Arg Val Arg 
        355                 360                 365             


Val Gly Phe Arg Leu Cys Asn Ser Thr Gly Gly Asp Cys Phe Tyr Arg 
    370                 375                 380                 


Gly Tyr Thr Ser Gly Val Ala Ala Val Gln Asp Trp Tyr His Phe His 
385                 390                 395                 400 


Tyr Val Asp Ile Leu Ala Leu Leu Pro Ala Ala Trp Glu Asp Ser His 
                405                 410                 415     


Gly Ser Gln Asp Gly His Phe Val Leu Ser Cys Ser Tyr Asp Gly Leu 
            420                 425                 430         


Asp Cys Gln Ala Arg Gln Phe Arg Thr Phe His His Pro Thr Tyr Gly 
        435                 440                 445             


Ser Cys Tyr Thr Val Asp Gly Val Trp Thr Ala Gln Arg Pro Gly Ile 
    450                 455                 460                 


Thr His Gly Val Gly Leu Val Leu Arg Val Glu Gln Gln Pro His Leu 
465                 470                 475                 480 


Pro Leu Leu Ser Thr Leu Ala Gly Ile Arg Val Met Val His Gly Arg 
                485                 490                 495     


Asn His Thr Pro Phe Leu Gly His His Ser Phe Ser Val Arg Pro Gly 
            500                 505                 510         


Thr Glu Ala Thr Ile Ser Ile Arg Glu Asp Glu Val His Arg Leu Gly 
        515                 520                 525             


Ser Pro Tyr Gly His Cys Thr Ala Gly Gly Glu Gly Val Glu Val Glu 
    530                 535                 540                 


Leu Leu His Asn Thr Ser Tyr Thr Arg Gln Ala Cys Leu Val Ser Cys 
545                 550                 555                 560 


Phe Gln Gln Leu Met Val Glu Thr Cys Ser Cys Gly Tyr Tyr Leu His 
                565                 570                 575     


Pro Leu Pro Ala Gly Ala Glu Tyr Cys Ser Ser Ala Arg His Pro Ala 
            580                 585                 590         


Trp Gly His Cys Phe Tyr Arg Leu Tyr Gln Asp Leu Glu Thr His Arg 
        595                 600                 605             


Leu Pro Cys Thr Ser Arg Cys Pro Arg Pro Cys Arg Glu Ser Ala Phe 
    610                 615                 620                 


Lys Leu Ser Thr Gly Thr Ser Arg Trp Pro Ser Ala Lys Ser Ala Gly 
625                 630                 635                 640 


Trp Thr Leu Ala Thr Leu Gly Glu Gln Gly Leu Pro His Gln Ser His 
                645                 650                 655     


Arg Gln Arg Ser Ser Leu Ala Lys Ile Asn Ile Val Tyr Gln Glu Leu 
            660                 665                 670         


Asn Tyr Arg Ser Val Glu Glu Ala Pro Val Tyr Ser Val Pro Gln Leu 
        675                 680                 685             


Leu Ser Ala Met Gly Ser Leu Cys Ser Leu Trp Phe Gly Ala Ser Val 
    690                 695                 700                 


Leu Ser Leu Leu Glu Leu Leu Glu Leu Leu Leu Asp Ala Ser Ala Leu 
705                 710                 715                 720 


Thr Leu Val Leu Gly Gly Arg Arg Leu Arg Arg Ala Trp Phe Ser Trp 
                725                 730                 735     


Pro Arg Ala Ser Pro Ala Ser Gly Ala Ser Ser Ile Lys Pro Glu Ala 
            740                 745                 750         


Ser Gln Met Pro Pro Pro Ala Gly Gly Thr Ser Asp Asp Pro Glu Pro 
        755                 760                 765             


Ser Gly Pro His Leu Pro Arg Val Met Leu Pro Gly Val Leu Ala Gly 
    770                 775                 780                 


Val Ser Ala Glu Glu Ser Trp Ala Gly Pro Gln Pro Leu Glu Thr Leu 
785                 790                 795                 800 


Asp Thr 
        


<210>  2742
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  2742

Met Arg Pro His Leu Ser Pro Pro Leu Gln Gln Leu Leu Leu Pro Val 
1               5                   10                  15      


Leu Leu Ala Cys Ala Ala His Ser Thr Gly Ala Leu Pro Arg Leu Cys 
            20                  25                  30          


Asp Val Leu Gln Val Leu Trp Glu Glu Gln Asp Gln Cys Leu Gln Glu 
        35                  40                  45              


Leu Ser Arg Glu Gln Thr Gly Asp Leu Gly Thr Glu Gln Pro Val Pro 
    50                  55                  60                  


Gly Cys Glu Gly Met Trp Asp Asn Ile Ser Cys Trp Pro Ser Ser Val 
65                  70                  75                  80  


Pro Gly Arg Met Val Glu Val Glu Cys Pro Arg Phe Leu Arg Met Leu 
                85                  90                  95      


Thr Ser Arg Asn Gly Ser Leu Phe Arg Asn Cys Thr Gln Asp Gly Trp 
            100                 105                 110         


Ser Glu Thr Phe Pro Arg Pro Asn Leu Ala Cys Gly Val Asn Val Asn 
        115                 120                 125             


Asp Ser Ser Asn Glu Lys Arg His Ser Tyr Leu Leu Lys Leu Lys Val 
    130                 135                 140                 


Met Tyr Thr Val Gly Tyr Ser Ser Ser Leu Val Met Leu Leu Val Ala 
145                 150                 155                 160 


Leu Gly Ile Leu Cys Ala Phe Arg Arg Leu His Cys Thr Arg Asn Tyr 
                165                 170                 175     


Ile His Met His Leu Phe Val Ser Phe Ile Leu Arg Ala Leu Ser Asn 
            180                 185                 190         


Phe Ile Lys Asp Ala Val Leu Phe Ser Ser Asp Asp Val Thr Tyr Cys 
        195                 200                 205             


Asp Ala His Arg Ala Gly Cys Lys Leu Val Met Val Leu Phe Gln Tyr 
    210                 215                 220                 


Cys Ile Met Ala Asn Tyr Ser Trp Leu Leu Val Glu Gly Leu Tyr Leu 
225                 230                 235                 240 


His Thr Leu Leu Ala Ile Ser Phe Phe Ser Glu Arg Lys Tyr Leu Gln 
                245                 250                 255     


Gly Phe Val Ala Phe Gly Trp Gly Ser Pro Ala Ile Phe Val Ala Leu 
            260                 265                 270         


Trp Ala Ile Ala Arg His Phe Leu Glu Asp Val Gly Cys Trp Asp Ile 
        275                 280                 285             


Asn Ala Asn Ala Ser Ile Trp Trp Ile Ile Arg Gly Pro Val Ile Leu 
    290                 295                 300                 


Ser Ile Leu Ile Asn Phe Ile Leu Phe Ile Asn Ile Leu Arg Ile Leu 
305                 310                 315                 320 


Met Arg Lys Leu Arg Thr Gln Glu Thr Arg Gly Asn Glu Val Ser His 
                325                 330                 335     


Tyr Lys Arg Leu Ala Arg Ser Thr Leu Leu Leu Ile Pro Leu Phe Gly 
            340                 345                 350         


Ile His Tyr Ile Val Phe Ala Phe Ser Pro Glu Asp Ala Met Glu Ile 
        355                 360                 365             


Gln Leu Phe Phe Glu Leu Ala Leu Gly Ser Phe Gln Gly Leu Val Val 
    370                 375                 380                 


Ala Val Leu Tyr Cys Phe Leu Asn Gly Glu Val Gln Leu Glu Val Gln 
385                 390                 395                 400 


Lys Lys Trp Gln Gln Trp His Leu Arg Glu Phe Pro Leu His Pro Val 
                405                 410                 415     


Ala Ser Phe Ser Asn Ser Thr Lys Ala Ser His Leu Glu Gln Ser Gln 
            420                 425                 430         


Gly Thr Cys Arg Thr Ser Ile Ile 
        435                 440 


<210>  2743
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  2743

Met Lys Leu Cys Val Thr Val Leu Ser Leu Leu Met Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Pro Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Thr Ser Ser Leu Cys Ser Gln Pro Ala Val Val 
    50                  55                  60                  


Phe Gln Thr Lys Arg Ser Lys Gln Val Cys Ala Asp Pro Ser Glu Ser 
65                  70                  75                  80  


Trp Val Gln Glu Tyr Val Tyr Asp Leu Glu Leu Asn 
                85                  90          


<210>  2744
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  2744

Met Lys Val Ser Ala Ala Leu Leu Trp Leu Leu Leu Ile Ala Ala Ala 
1               5                   10                  15      


Phe Ser Pro Gln Gly Leu Ala Gly Pro Ala Ser Val Pro Thr Thr Cys 
            20                  25                  30          


Cys Phe Asn Leu Ala Asn Arg Lys Ile Pro Leu Gln Arg Leu Glu Ser 
        35                  40                  45              


Tyr Arg Arg Ile Thr Ser Gly Lys Cys Pro Gln Lys Ala Val Ile Phe 
    50                  55                  60                  


Lys Thr Lys Leu Ala Lys Asp Ile Cys Ala Asp Pro Lys Lys Lys Trp 
65                  70                  75                  80  


Val Gln Asp Ser Met Lys Tyr Leu Asp Gln Lys Ser Pro Thr Pro Lys 
                85                  90                  95      


Pro 
    


<210>  2745
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  2745

Met Asp Arg Leu Gln Thr Ala Leu Leu Val Val Leu Val Leu Leu Ala 
1               5                   10                  15      


Val Ala Leu Gln Ala Thr Glu Ala Gly Pro Tyr Gly Ala Asn Met Glu 
            20                  25                  30          


Asp Ser Val Cys Cys Arg Asp Tyr Val Arg Tyr Arg Leu Pro Leu Arg 
        35                  40                  45              


Val Val Lys His Phe Tyr Trp Thr Ser Asp Ser Cys Pro Arg Pro Gly 
    50                  55                  60                  


Val Val Leu Leu Thr Phe Arg Asp Lys Glu Ile Cys Ala Asp Pro Arg 
65                  70                  75                  80  


Val Pro Trp Val Lys Met Ile Leu Asn Lys Leu Ser Gln 
                85                  90              


<210>  2746
<211>  397
<212>  PRT
<213>  Homo sapiens

<400>  2746

Met Ala Pro Ile Ser Leu Ser Trp Leu Leu Arg Leu Ala Thr Phe Cys 
1               5                   10                  15      


His Leu Thr Val Leu Leu Ala Gly Gln His His Gly Val Thr Lys Cys 
            20                  25                  30          


Asn Ile Thr Cys Ser Lys Met Thr Ser Lys Ile Pro Val Ala Leu Leu 
        35                  40                  45              


Ile His Tyr Gln Gln Asn Gln Ala Ser Cys Gly Lys Arg Ala Ile Ile 
    50                  55                  60                  


Leu Glu Thr Arg Gln His Arg Leu Phe Cys Ala Asp Pro Lys Glu Gln 
65                  70                  75                  80  


Trp Val Lys Asp Ala Met Gln His Leu Asp Arg Gln Ala Ala Ala Leu 
                85                  90                  95      


Thr Arg Asn Gly Gly Thr Phe Glu Lys Gln Ile Gly Glu Val Lys Pro 
            100                 105                 110         


Arg Thr Thr Pro Ala Ala Gly Gly Met Asp Glu Ser Val Val Leu Glu 
        115                 120                 125             


Pro Glu Ala Thr Gly Glu Ser Ser Ser Leu Glu Pro Thr Pro Ser Ser 
    130                 135                 140                 


Gln Glu Ala Gln Arg Ala Leu Gly Thr Ser Pro Glu Leu Pro Thr Gly 
145                 150                 155                 160 


Val Thr Gly Ser Ser Gly Thr Arg Leu Pro Pro Thr Pro Lys Ala Gln 
                165                 170                 175     


Asp Gly Gly Pro Val Gly Thr Glu Leu Phe Arg Val Pro Pro Val Ser 
            180                 185                 190         


Thr Ala Ala Thr Trp Gln Ser Ser Ala Pro His Gln Pro Gly Pro Ser 
        195                 200                 205             


Leu Trp Ala Glu Ala Lys Thr Ser Glu Ala Pro Ser Thr Gln Asp Pro 
    210                 215                 220                 


Ser Thr Gln Ala Ser Thr Ala Ser Ser Pro Ala Pro Glu Glu Asn Ala 
225                 230                 235                 240 


Pro Ser Glu Gly Gln Arg Val Trp Gly Gln Gly Gln Ser Pro Arg Pro 
                245                 250                 255     


Glu Asn Ser Leu Glu Arg Glu Glu Met Gly Pro Val Pro Ala His Thr 
            260                 265                 270         


Asp Ala Phe Gln Asp Trp Gly Pro Gly Ser Met Ala His Val Ser Val 
        275                 280                 285             


Val Pro Val Ser Ser Glu Gly Thr Pro Ser Arg Glu Pro Val Ala Ser 
    290                 295                 300                 


Gly Ser Trp Thr Pro Lys Ala Glu Glu Pro Ile His Ala Thr Met Asp 
305                 310                 315                 320 


Pro Gln Arg Leu Gly Val Leu Ile Thr Pro Val Pro Asp Ala Gln Ala 
                325                 330                 335     


Ala Thr Arg Arg Gln Ala Val Gly Leu Leu Ala Phe Leu Gly Leu Leu 
            340                 345                 350         


Phe Cys Leu Gly Val Ala Met Phe Thr Tyr Gln Ser Leu Gln Gly Cys 
        355                 360                 365             


Pro Arg Lys Met Ala Gly Glu Met Ala Glu Gly Leu Arg Tyr Ile Pro 
    370                 375                 380                 


Arg Ser Cys Gly Ser Asn Ser Tyr Val Leu Val Pro Val 
385                 390                 395         


<210>  2747
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  2747

Met Arg Arg Ala Ala Leu Trp Leu Trp Leu Cys Ala Leu Ala Leu Ser 
1               5                   10                  15      


Leu Gln Pro Ala Leu Pro Gln Ile Val Ala Thr Asn Leu Pro Pro Glu 
            20                  25                  30          


Asp Gln Asp Gly Ser Gly Asp Asp Ser Asp Asn Phe Ser Gly Ser Gly 
        35                  40                  45              


Ala Gly Ala Leu Gln Asp Ile Thr Leu Ser Gln Gln Thr Pro Ser Thr 
    50                  55                  60                  


Trp Lys Asp Thr Gln Leu Leu Thr Ala Ile Pro Thr Ser Pro Glu Pro 
65                  70                  75                  80  


Thr Gly Leu Glu Ala Thr Ala Ala Ser Thr Ser Thr Leu Pro Ala Gly 
                85                  90                  95      


Glu Gly Pro Lys Glu Gly Glu Ala Val Val Leu Pro Glu Val Glu Pro 
            100                 105                 110         


Gly Leu Thr Ala Arg Glu Gln Glu Ala Thr Pro Arg Pro Arg Glu Thr 
        115                 120                 125             


Thr Gln Leu Pro Thr Thr His Gln Ala Ser Thr Thr Thr Ala Thr Thr 
    130                 135                 140                 


Ala Gln Glu Pro Ala Thr Ser His Pro His Arg Asp Met Gln Pro Gly 
145                 150                 155                 160 


His His Glu Thr Ser Thr Pro Ala Gly Pro Ser Gln Ala Asp Leu His 
                165                 170                 175     


Thr Pro His Thr Glu Asp Gly Gly Pro Ser Ala Thr Glu Arg Ala Ala 
            180                 185                 190         


Glu Asp Gly Ala Ser Ser Gln Leu Pro Ala Ala Glu Gly Ser Gly Glu 
        195                 200                 205             


Gln Asp Phe Thr Phe Glu Thr Ser Gly Glu Asn Thr Ala Val Val Ala 
    210                 215                 220                 


Val Glu Pro Asp Arg Arg Asn Gln Ser Pro Val Asp Gln Gly Ala Thr 
225                 230                 235                 240 


Gly Ala Ser Gln Gly Leu Leu Asp Arg Lys Glu Val Leu Gly Gly Val 
                245                 250                 255     


Ile Ala Gly Gly Leu Val Gly Leu Ile Phe Ala Val Cys Leu Val Gly 
            260                 265                 270         


Phe Met Leu Tyr Arg Met Lys Lys Lys Asp Glu Gly Ser Tyr Ser Leu 
        275                 280                 285             


Glu Glu Pro Lys Gln Ala Asn Gly Gly Ala Tyr Gln Lys Pro Thr Lys 
    290                 295                 300                 


Gln Glu Glu Phe Tyr Ala 
305                 310 


<210>  2748
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  2748

Met Arg Arg Ala Trp Ile Leu Leu Thr Leu Gly Leu Val Ala Cys Val 
1               5                   10                  15      


Ser Ala Glu Ser Arg Ala Glu Leu Thr Ser Asp Lys Asp Met Tyr Leu 
            20                  25                  30          


Asp Asn Ser Ser Ile Glu Glu Ala Ser Gly Val Tyr Pro Ile Asp Asp 
        35                  40                  45              


Asp Asp Tyr Ala Ser Ala Ser Gly Ser Gly Ala Asp Glu Asp Val Glu 
    50                  55                  60                  


Ser Pro Glu Leu Thr Thr Ser Arg Pro Leu Pro Lys Ile Leu Leu Thr 
65                  70                  75                  80  


Ser Ala Ala Pro Lys Val Glu Thr Thr Thr Leu Asn Ile Gln Asn Lys 
                85                  90                  95      


Ile Pro Ala Gln Thr Lys Ser Pro Glu Glu Thr Asp Lys Glu Lys Val 
            100                 105                 110         


His Leu Ser Asp Ser Glu Arg Lys Met Asp Pro Ala Glu Glu Asp Thr 
        115                 120                 125             


Asn Val Tyr Thr Glu Lys His Ser Asp Ser Leu Phe Lys Arg Thr Glu 
    130                 135                 140                 


Val Leu Ala Ala Val Ile Ala Gly Gly Val Ile Gly Phe Leu Phe Ala 
145                 150                 155                 160 


Ile Phe Leu Ile Leu Leu Leu Val Tyr Arg Met Arg Lys Lys Asp Glu 
                165                 170                 175     


Gly Ser Tyr Asp Leu Gly Glu Arg Lys Pro Ser Ser Ala Ala Tyr Gln 
            180                 185                 190         


Lys Ala Pro Thr Lys Glu Phe Tyr Ala 
        195                 200     


<210>  2749
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  2749

Met Ala Pro Ala Arg Leu Phe Ala Leu Leu Leu Phe Phe Val Gly Gly 
1               5                   10                  15      


Val Ala Glu Ser Ile Arg Glu Thr Glu Val Ile Asp Pro Gln Asp Leu 
            20                  25                  30          


Leu Glu Gly Arg Tyr Phe Ser Gly Ala Leu Pro Asp Asp Glu Asp Val 
        35                  40                  45              


Val Gly Pro Gly Gln Glu Ser Asp Asp Phe Glu Leu Ser Gly Ser Gly 
    50                  55                  60                  


Asp Leu Asp Asp Leu Glu Asp Ser Met Ile Gly Pro Glu Val Val His 
65                  70                  75                  80  


Pro Leu Val Pro Leu Asp Asn His Ile Pro Glu Arg Ala Gly Ser Gly 
                85                  90                  95      


Ser Gln Val Pro Thr Glu Pro Lys Lys Leu Glu Glu Asn Glu Val Ile 
            100                 105                 110         


Pro Lys Arg Ile Ser Pro Val Glu Glu Ser Glu Asp Val Ser Asn Lys 
        115                 120                 125             


Val Ser Met Ser Ser Thr Val Gln Gly Ser Asn Ile Phe Glu Arg Thr 
    130                 135                 140                 


Glu Val Leu Ala Ala Leu Ile Val Gly Gly Ile Val Gly Ile Leu Phe 
145                 150                 155                 160 


Ala Val Phe Leu Ile Leu Leu Leu Met Tyr Arg Met Lys Lys Lys Asp 
                165                 170                 175     


Glu Gly Ser Tyr Asp Leu Gly Lys Lys Pro Ile Tyr Lys Lys Ala Pro 
            180                 185                 190         


Thr Asn Glu Phe Tyr Ala 
        195             


<210>  2750
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  2750

Met Ala Ala Leu Leu Leu Arg His Val Gly Arg His Cys Leu Arg Ala 
1               5                   10                  15      


His Phe Ser Pro Gln Leu Cys Ile Arg Asn Ala Val Pro Leu Gly Thr 
            20                  25                  30          


Thr Ala Lys Glu Glu Met Glu Arg Phe Trp Asn Lys Asn Ile Gly Ser 
        35                  40                  45              


Asn Arg Pro Leu Ser Pro His Ile Thr Ile Tyr Ser Trp Ser Leu Pro 
    50                  55                  60                  


Met Ala Met Ser Ile Cys His Arg Gly Thr Gly Ile Ala Leu Ser Ala 
65                  70                  75                  80  


Gly Val Ser Leu Phe Gly Met Ser Ala Leu Leu Leu Pro Gly Asn Phe 
                85                  90                  95      


Glu Ser Tyr Leu Glu Leu Val Lys Ser Leu Cys Leu Gly Pro Ala Leu 
            100                 105                 110         


Ile His Thr Ala Lys Phe Ala Leu Val Phe Pro Leu Met Tyr His Thr 
        115                 120                 125             


Trp Asn Gly Ile Arg His Leu Met Trp Asp Leu Gly Lys Gly Leu Lys 
    130                 135                 140                 


Ile Pro Gln Leu Tyr Gln Ser Gly Val Val Val Leu Val Leu Thr Val 
145                 150                 155                 160 


Leu Ser Ser Met Gly Leu Ala Ala Met 
                165                 


<210>  2751
<211>  830
<212>  PRT
<213>  Homo sapiens

<400>  2751

Met Ala Asn Cys Gln Ile Ala Ile Leu Tyr Gln Arg Phe Gln Arg Val 
1               5                   10                  15      


Val Phe Gly Ile Ser Gln Leu Leu Cys Phe Ser Ala Leu Ile Ser Glu 
            20                  25                  30          


Leu Thr Asn Gln Lys Glu Val Ala Ala Trp Thr Tyr His Tyr Ser Thr 
        35                  40                  45              


Lys Ala Tyr Ser Trp Asn Ile Ser Arg Lys Tyr Cys Gln Asn Arg Tyr 
    50                  55                  60                  


Thr Asp Leu Val Ala Ile Gln Asn Lys Asn Glu Ile Asp Tyr Leu Asn 
65                  70                  75                  80  


Lys Val Leu Pro Tyr Tyr Ser Ser Tyr Tyr Trp Ile Gly Ile Arg Lys 
                85                  90                  95      


Asn Asn Lys Thr Trp Thr Trp Val Gly Thr Lys Lys Ala Leu Thr Asn 
            100                 105                 110         


Glu Ala Glu Asn Trp Ala Asp Asn Glu Pro Asn Asn Lys Arg Asn Asn 
        115                 120                 125             


Glu Asp Cys Val Glu Ile Tyr Ile Lys Ser Pro Ser Ala Pro Gly Lys 
    130                 135                 140                 


Trp Asn Asp Glu His Cys Leu Lys Lys Lys His Ala Leu Cys Tyr Thr 
145                 150                 155                 160 


Ala Ser Cys Gln Asp Met Ser Cys Ser Lys Gln Gly Glu Cys Leu Glu 
                165                 170                 175     


Thr Ile Gly Asn Tyr Thr Cys Ser Cys Tyr Pro Gly Phe Tyr Gly Pro 
            180                 185                 190         


Glu Cys Glu Tyr Val Arg Glu Cys Gly Glu Leu Glu Leu Pro Gln His 
        195                 200                 205             


Val Leu Met Asn Cys Ser His Pro Leu Gly Asn Phe Ser Phe Asn Ser 
    210                 215                 220                 


Gln Cys Ser Phe His Cys Thr Asp Gly Tyr Gln Val Asn Gly Pro Ser 
225                 230                 235                 240 


Lys Leu Glu Cys Leu Ala Ser Gly Ile Trp Thr Asn Lys Pro Pro Gln 
                245                 250                 255     


Cys Leu Ala Ala Gln Cys Pro Pro Leu Lys Ile Pro Glu Arg Gly Asn 
            260                 265                 270         


Met Thr Cys Leu His Ser Ala Lys Ala Phe Gln His Gln Ser Ser Cys 
        275                 280                 285             


Ser Phe Ser Cys Glu Glu Gly Phe Ala Leu Val Gly Pro Glu Val Val 
    290                 295                 300                 


Gln Cys Thr Ala Ser Gly Val Trp Thr Ala Pro Ala Pro Val Cys Lys 
305                 310                 315                 320 


Ala Val Gln Cys Gln His Leu Glu Ala Pro Ser Glu Gly Thr Met Asp 
                325                 330                 335     


Cys Val His Pro Leu Thr Ala Phe Ala Tyr Gly Ser Ser Cys Lys Phe 
            340                 345                 350         


Glu Cys Gln Pro Gly Tyr Arg Val Arg Gly Leu Asp Met Leu Arg Cys 
        355                 360                 365             


Ile Asp Ser Gly His Trp Ser Ala Pro Leu Pro Thr Cys Glu Ala Ile 
    370                 375                 380                 


Ser Cys Glu Pro Leu Glu Ser Pro Val His Gly Ser Met Asp Cys Ser 
385                 390                 395                 400 


Pro Ser Leu Arg Ala Phe Gln Tyr Asp Thr Asn Cys Ser Phe Arg Cys 
                405                 410                 415     


Ala Glu Gly Phe Met Leu Arg Gly Ala Asp Ile Val Arg Cys Asp Asn 
            420                 425                 430         


Leu Gly Gln Trp Thr Ala Pro Ala Pro Val Cys Gln Ala Leu Gln Cys 
        435                 440                 445             


Gln Asp Leu Pro Val Pro Asn Glu Ala Arg Val Asn Cys Ser His Pro 
    450                 455                 460                 


Phe Gly Ala Phe Arg Tyr Gln Ser Val Cys Ser Phe Thr Cys Asn Glu 
465                 470                 475                 480 


Gly Leu Leu Leu Val Gly Ala Ser Val Leu Gln Cys Leu Ala Thr Gly 
                485                 490                 495     


Asn Trp Asn Ser Val Pro Pro Glu Cys Gln Ala Ile Pro Cys Thr Pro 
            500                 505                 510         


Leu Leu Ser Pro Gln Asn Gly Thr Met Thr Cys Val Gln Pro Leu Gly 
        515                 520                 525             


Ser Ser Ser Tyr Lys Ser Thr Cys Gln Phe Ile Cys Asp Glu Gly Tyr 
    530                 535                 540                 


Ser Leu Ser Gly Pro Glu Arg Leu Asp Cys Thr Arg Ser Gly Arg Trp 
545                 550                 555                 560 


Thr Asp Ser Pro Pro Met Cys Glu Ala Ile Lys Cys Pro Glu Leu Phe 
                565                 570                 575     


Ala Pro Glu Gln Gly Ser Leu Asp Cys Ser Asp Thr Arg Gly Glu Phe 
            580                 585                 590         


Asn Val Gly Ser Thr Cys His Phe Ser Cys Asp Asn Gly Phe Lys Leu 
        595                 600                 605             


Glu Gly Pro Asn Asn Val Glu Cys Thr Thr Ser Gly Arg Trp Ser Ala 
    610                 615                 620                 


Thr Pro Pro Thr Cys Lys Gly Ile Ala Ser Leu Pro Thr Pro Gly Val 
625                 630                 635                 640 


Gln Cys Pro Ala Leu Thr Thr Pro Gly Gln Gly Thr Met Tyr Cys Arg 
                645                 650                 655     


His His Pro Gly Thr Phe Gly Phe Asn Thr Thr Cys Tyr Phe Gly Cys 
            660                 665                 670         


Asn Ala Gly Phe Thr Leu Ile Gly Asp Ser Thr Leu Ser Cys Arg Pro 
        675                 680                 685             


Ser Gly Gln Trp Thr Ala Val Thr Pro Ala Cys Arg Ala Val Lys Cys 
    690                 695                 700                 


Ser Glu Leu His Val Asn Lys Pro Ile Ala Met Asn Cys Ser Asn Leu 
705                 710                 715                 720 


Trp Gly Asn Phe Ser Tyr Gly Ser Ile Cys Ser Phe His Cys Leu Glu 
                725                 730                 735     


Gly Gln Leu Leu Asn Gly Ser Ala Gln Thr Ala Cys Gln Glu Asn Gly 
            740                 745                 750         


His Trp Ser Thr Thr Val Pro Thr Cys Gln Ala Gly Pro Leu Thr Ile 
        755                 760                 765             


Gln Glu Ala Leu Thr Tyr Phe Gly Gly Ala Val Ala Ser Thr Ile Gly 
    770                 775                 780                 


Leu Ile Met Gly Gly Thr Leu Leu Ala Leu Leu Arg Lys Arg Phe Arg 
785                 790                 795                 800 


Gln Lys Asp Asp Gly Lys Cys Pro Leu Asn Pro His Ser His Leu Gly 
                805                 810                 815     


Thr Tyr Gly Val Phe Thr Asn Ala Ala Phe Asp Pro Ser Pro 
            820                 825                 830 


<210>  2752
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  2752

Met Pro Leu Gln Leu Leu Leu Leu Leu Ile Leu Leu Gly Pro Gly Asn 
1               5                   10                  15      


Ser Leu Gln Leu Trp Asp Thr Trp Ala Asp Glu Ala Glu Lys Ala Leu 
            20                  25                  30          


Gly Pro Leu Leu Ala Arg Asp Arg Arg Gln Ala Thr Glu Tyr Glu Tyr 
        35                  40                  45              


Leu Asp Tyr Asp Phe Leu Pro Glu Thr Glu Pro Pro Glu Met Leu Arg 
    50                  55                  60                  


Asn Ser Thr Asp Thr Thr Pro Leu Thr Gly Pro Gly Thr Pro Glu Ser 
65                  70                  75                  80  


Thr Thr Val Glu Pro Ala Ala Arg Arg Ser Thr Gly Leu Asp Ala Gly 
                85                  90                  95      


Gly Ala Val Thr Glu Leu Thr Thr Glu Leu Ala Asn Met Gly Asn Leu 
            100                 105                 110         


Ser Thr Asp Ser Ala Ala Met Glu Ile Gln Thr Thr Gln Pro Ala Ala 
        115                 120                 125             


Thr Glu Ala Gln Thr Thr Gln Pro Val Pro Thr Glu Ala Gln Thr Thr 
    130                 135                 140                 


Pro Leu Ala Ala Thr Glu Ala Gln Thr Thr Arg Leu Thr Ala Thr Glu 
145                 150                 155                 160 


Ala Gln Thr Thr Pro Leu Ala Ala Thr Glu Ala Gln Thr Thr Pro Pro 
                165                 170                 175     


Ala Ala Thr Glu Ala Gln Thr Thr Gln Pro Thr Gly Leu Glu Ala Gln 
            180                 185                 190         


Thr Thr Ala Pro Ala Ala Met Glu Ala Gln Thr Thr Ala Pro Ala Ala 
        195                 200                 205             


Met Glu Ala Gln Thr Thr Pro Pro Ala Ala Met Glu Ala Gln Thr Thr 
    210                 215                 220                 


Gln Thr Thr Ala Met Glu Ala Gln Thr Thr Ala Pro Glu Ala Thr Glu 
225                 230                 235                 240 


Ala Gln Thr Thr Gln Pro Thr Ala Thr Glu Ala Gln Thr Thr Pro Leu 
                245                 250                 255     


Ala Ala Met Glu Ala Leu Ser Thr Glu Pro Ser Ala Thr Glu Ala Leu 
            260                 265                 270         


Ser Met Glu Pro Thr Thr Lys Arg Gly Leu Phe Ile Pro Phe Ser Val 
        275                 280                 285             


Ser Ser Val Thr His Lys Gly Ile Pro Met Ala Ala Ser Asn Leu Ser 
    290                 295                 300                 


Val Asn Tyr Pro Val Gly Ala Pro Asp His Ile Ser Val Lys Gln Cys 
305                 310                 315                 320 


Leu Leu Ala Ile Leu Ile Leu Ala Leu Val Ala Thr Ile Phe Phe Val 
                325                 330                 335     


Cys Thr Val Val Leu Ala Val Arg Leu Ser Arg Lys Gly His Met Tyr 
            340                 345                 350         


Pro Val Arg Asn Tyr Ser Pro Thr Glu Met Val Cys Ile Ser Ser Leu 
        355                 360                 365             


Leu Pro Asp Gly Gly Glu Gly Pro Ser Ala Thr Ala Asn Gly Gly Leu 
    370                 375                 380                 


Ser Lys Ala Lys Ser Pro Gly Leu Thr Pro Glu Pro Arg Glu Asp Arg 
385                 390                 395                 400 


Glu Gly Asp Asp Leu Thr Leu His Ser Phe Leu Pro 
                405                 410         


<210>  2753
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  2753

Met Gly Ile Gly Arg Ser Glu Gly Gly Arg Arg Gly Ala Ala Leu Gly 
1               5                   10                  15      


Val Leu Leu Ala Leu Gly Ala Ala Leu Leu Ala Val Gly Ser Ala Ser 
            20                  25                  30          


Glu Tyr Asp Tyr Val Ser Phe Gln Ser Asp Ile Gly Pro Tyr Gln Ser 
        35                  40                  45              


Gly Arg Phe Tyr Thr Lys Pro Pro Gln Cys Val Asp Ile Pro Ala Asp 
    50                  55                  60                  


Leu Arg Leu Cys His Asn Val Gly Tyr Lys Lys Met Val Leu Pro Asn 
65                  70                  75                  80  


Leu Leu Glu His Glu Thr Met Ala Glu Val Lys Gln Gln Ala Ser Ser 
                85                  90                  95      


Trp Val Pro Leu Leu Asn Lys Asn Cys His Ala Gly Thr Gln Val Phe 
            100                 105                 110         


Leu Cys Ser Leu Phe Ala Pro Val Cys Leu Asp Arg Pro Ile Tyr Pro 
        115                 120                 125             


Cys Arg Trp Leu Cys Glu Ala Val Arg Asp Ser Cys Glu Pro Val Met 
    130                 135                 140                 


Gln Phe Phe Gly Phe Tyr Trp Pro Glu Met Leu Lys Cys Asp Lys Phe 
145                 150                 155                 160 


Pro Glu Gly Asp Val Cys Ile Ala Met Thr Pro Pro Asn Ala Thr Glu 
                165                 170                 175     


Ala Ser Lys Pro Gln Gly Thr Thr Val Cys Pro Pro Cys Asp Asn Glu 
            180                 185                 190         


Leu Lys Ser Glu Ala Ile Ile Glu His Leu Cys Ala Ser Glu Phe Ala 
        195                 200                 205             


Leu Arg Met Lys Ile Lys Glu Val Lys Lys Glu Asn Gly Asp Lys Lys 
    210                 215                 220                 


Ile Val Pro Lys Lys Lys Lys Pro Leu Lys Leu Gly Pro Ile Lys Lys 
225                 230                 235                 240 


Lys Asp Leu Lys Lys Leu Val Leu Tyr Leu Lys Asn Gly Ala Asp Cys 
                245                 250                 255     


Pro Cys His Gln Leu Asp Asn Leu Ser His His Phe Leu Ile Met Gly 
            260                 265                 270         


Arg Lys Val Lys Ser Gln Tyr Leu Leu Thr Ala Ile His Lys Trp Asp 
        275                 280                 285             


Lys Lys Asn Lys Glu Phe Lys Asn Phe Met Lys Lys Met Lys Asn His 
    290                 295                 300                 


Glu Cys Pro Thr Phe Gln Ser Val Phe Lys 
305                 310                 


<210>  2754
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  2754

Met Asp Val Gly Ser Lys Glu Val Leu Met Glu Ser Pro Pro Asp Tyr 
1               5                   10                  15      


Ser Ala Ala Pro Arg Gly Arg Phe Gly Ile Pro Cys Cys Pro Val His 
            20                  25                  30          


Leu Lys Arg Leu Leu Ile Val Val Val Val Val Val Leu Ile Val Val 
        35                  40                  45              


Val Ile Val Gly Ala Leu Leu Met Gly Leu His Met Ser Gln Lys His 
    50                  55                  60                  


Thr Glu Met Val Leu Glu Met Ser Ile Gly Ala Pro Glu Ala Gln Gln 
65                  70                  75                  80  


Arg Leu Ala Leu Ser Glu His Leu Val Thr Thr Ala Thr Phe Ser Ile 
                85                  90                  95      


Gly Ser Thr Gly Leu Val Val Tyr Asp Tyr Gln Gln Leu Leu Ile Ala 
            100                 105                 110         


Tyr Lys Pro Ala Pro Gly Thr Cys Cys Tyr Ile Met Lys Ile Ala Pro 
        115                 120                 125             


Glu Ser Ile Pro Ser Leu Glu Ala Leu Thr Arg Lys Val His Asn Phe 
    130                 135                 140                 


Gln Met Glu Cys Ser Leu Gln Ala Lys Pro Ala Val Pro Thr Ser Lys 
145                 150                 155                 160 


Leu Gly Gln Ala Glu Gly Arg Asp Ala Gly Ser Ala Pro Ser Gly Gly 
                165                 170                 175     


Asp Pro Ala Phe Leu Gly Met Ala Val Ser Thr Leu Cys Gly Glu Val 
            180                 185                 190         


Pro Leu Tyr Tyr Ile 
        195         


<210>  2755
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  2755

Met Leu Leu Phe Leu Leu Ser Ala Leu Val Leu Leu Thr Gln Pro Leu 
1               5                   10                  15      


Gly Tyr Leu Glu Ala Glu Met Lys Thr Tyr Ser His Arg Thr Met Pro 
            20                  25                  30          


Ser Ala Cys Thr Leu Val Met Cys Ser Ser Val Glu Ser Gly Leu Pro 
        35                  40                  45              


Gly Arg Asp Gly Arg Asp Gly Arg Glu Gly Pro Arg Gly Glu Lys Gly 
    50                  55                  60                  


Asp Pro Gly Leu Pro Gly Ala Ala Gly Gln Ala Gly Met Pro Gly Gln 
65                  70                  75                  80  


Ala Gly Pro Val Gly Pro Lys Gly Asp Asn Gly Ser Val Gly Glu Pro 
                85                  90                  95      


Gly Pro Lys Gly Asp Thr Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly 
            100                 105                 110         


Val Pro Gly Pro Ala Gly Arg Glu Gly Pro Leu Gly Lys Gln Gly Asn 
        115                 120                 125             


Ile Gly Pro Gln Gly Lys Pro Gly Pro Lys Gly Glu Ala Gly Pro Lys 
    130                 135                 140                 


Gly Glu Val Gly Ala Pro Gly Met Gln Gly Ser Ala Gly Ala Arg Gly 
145                 150                 155                 160 


Leu Ala Gly Pro Lys Gly Glu Arg Gly Val Pro Gly Glu Arg Gly Val 
                165                 170                 175     


Pro Gly Asn Thr Gly Ala Ala Gly Ser Ala Gly Ala Met Gly Pro Gln 
            180                 185                 190         


Gly Ser Pro Gly Ala Arg Gly Pro Pro Gly Leu Lys Gly Asp Lys Gly 
        195                 200                 205             


Ile Pro Gly Asp Lys Gly Ala Lys Gly Glu Ser Gly Leu Pro Asp Val 
    210                 215                 220                 


Ala Ser Leu Arg Gln Gln Val Glu Ala Leu Gln Gly Gln Val Gln His 
225                 230                 235                 240 


Leu Gln Ala Ala Phe Ser Gln Tyr Lys Lys Val Glu Leu Phe Pro Asn 
                245                 250                 255     


Gly Gln Ser Val Gly Glu Lys Ile Phe Lys Thr Ala Gly Phe Val Lys 
            260                 265                 270         


Pro Phe Thr Glu Ala Gln Leu Leu Cys Thr Gln Ala Gly Gly Gln Leu 
        275                 280                 285             


Ala Ser Pro Arg Ser Ala Ala Glu Asn Ala Ala Leu Gln Gln Leu Val 
    290                 295                 300                 


Val Ala Lys Asn Glu Ala Ala Phe Leu Ser Met Thr Asp Ser Lys Thr 
305                 310                 315                 320 


Glu Gly Lys Phe Thr Tyr Pro Thr Gly Glu Ser Leu Val Tyr Ser Asn 
                325                 330                 335     


Trp Ala Pro Gly Glu Pro Asn Asp Asp Gly Gly Ser Glu Asp Cys Val 
            340                 345                 350         


Glu Ile Phe Thr Asn Gly Lys Trp Asn Asp Arg Ala Cys Gly Glu Lys 
        355                 360                 365             


Arg Leu Val Val Cys Glu Phe 
    370                 375 


<210>  2756
<211>  1721
<212>  PRT
<213>  Homo sapiens

<400>  2756

Met Ala Gln Phe Pro Thr Pro Phe Gly Gly Ser Leu Asp Ile Trp Ala 
1               5                   10                  15      


Ile Thr Val Glu Glu Arg Ala Lys His Asp Gln Gln Phe His Ser Leu 
            20                  25                  30          


Lys Pro Ile Ser Gly Phe Ile Thr Gly Asp Gln Ala Arg Asn Phe Phe 
        35                  40                  45              


Phe Gln Ser Gly Leu Pro Gln Pro Val Leu Ala Gln Ile Trp Ala Leu 
    50                  55                  60                  


Ala Asp Met Asn Asn Asp Gly Arg Met Asp Gln Val Glu Phe Ser Ile 
65                  70                  75                  80  


Ala Met Lys Leu Ile Lys Leu Lys Leu Gln Gly Tyr Gln Leu Pro Ser 
                85                  90                  95      


Ala Leu Pro Pro Val Met Lys Gln Gln Pro Val Ala Ile Ser Ser Ala 
            100                 105                 110         


Pro Ala Phe Gly Met Gly Gly Ile Ala Ser Met Pro Pro Leu Thr Ala 
        115                 120                 125             


Val Ala Pro Val Pro Met Gly Ser Ile Pro Val Val Gly Met Ser Pro 
    130                 135                 140                 


Thr Leu Val Ser Ser Val Pro Thr Ala Ala Val Pro Pro Leu Ala Asn 
145                 150                 155                 160 


Gly Ala Pro Pro Val Ile Gln Pro Leu Pro Ala Phe Ala His Pro Ala 
                165                 170                 175     


Ala Thr Leu Pro Lys Ser Ser Ser Phe Ser Arg Ser Gly Pro Gly Ser 
            180                 185                 190         


Gln Leu Asn Thr Lys Leu Gln Lys Ala Gln Ser Phe Asp Val Ala Ser 
        195                 200                 205             


Val Pro Pro Val Ala Glu Trp Ala Val Pro Gln Ser Ser Arg Leu Lys 
    210                 215                 220                 


Tyr Arg Gln Leu Phe Asn Ser His Asp Lys Thr Met Ser Gly His Leu 
225                 230                 235                 240 


Thr Gly Pro Gln Ala Arg Thr Ile Leu Met Gln Ser Ser Leu Pro Gln 
                245                 250                 255     


Ala Gln Leu Ala Ser Ile Trp Asn Leu Ser Asp Ile Asp Gln Asp Gly 
            260                 265                 270         


Lys Leu Thr Ala Glu Glu Phe Ile Leu Ala Met His Leu Ile Asp Val 
        275                 280                 285             


Ala Met Ser Gly Gln Pro Leu Pro Pro Val Leu Pro Pro Glu Tyr Ile 
    290                 295                 300                 


Pro Pro Ser Phe Arg Arg Val Arg Ser Gly Ser Gly Ile Ser Val Ile 
305                 310                 315                 320 


Ser Ser Thr Ser Val Asp Gln Arg Leu Pro Glu Glu Pro Val Leu Glu 
                325                 330                 335     


Asp Glu Gln Gln Gln Leu Glu Lys Lys Leu Pro Val Thr Phe Glu Asp 
            340                 345                 350         


Lys Lys Arg Glu Asn Phe Glu Arg Gly Asn Leu Glu Leu Glu Lys Arg 
        355                 360                 365             


Arg Gln Ala Leu Leu Glu Gln Gln Arg Lys Glu Gln Glu Arg Leu Ala 
    370                 375                 380                 


Gln Leu Glu Arg Ala Glu Gln Glu Arg Lys Glu Arg Glu Arg Gln Glu 
385                 390                 395                 400 


Gln Glu Arg Lys Arg Gln Leu Glu Leu Glu Lys Gln Leu Glu Lys Gln 
                405                 410                 415     


Arg Glu Leu Glu Arg Gln Arg Glu Glu Glu Arg Arg Lys Glu Ile Glu 
            420                 425                 430         


Arg Arg Glu Ala Ala Lys Arg Glu Leu Glu Arg Gln Arg Gln Leu Glu 
        435                 440                 445             


Trp Glu Arg Asn Arg Arg Gln Glu Leu Leu Asn Gln Arg Asn Lys Glu 
    450                 455                 460                 


Gln Glu Asp Ile Val Val Leu Lys Ala Lys Lys Lys Thr Leu Glu Phe 
465                 470                 475                 480 


Glu Leu Glu Ala Leu Asn Asp Lys Lys His Gln Leu Glu Gly Lys Leu 
                485                 490                 495     


Gln Asp Ile Arg Cys Arg Leu Thr Thr Gln Arg Gln Glu Ile Glu Ser 
            500                 505                 510         


Thr Asn Lys Ser Arg Glu Leu Arg Ile Ala Glu Ile Thr His Leu Gln 
        515                 520                 525             


Gln Gln Leu Gln Glu Ser Gln Gln Met Leu Gly Arg Leu Ile Pro Glu 
    530                 535                 540                 


Lys Gln Ile Leu Asn Asp Gln Leu Lys Gln Val Gln Gln Asn Ser Leu 
545                 550                 555                 560 


His Arg Asp Ser Leu Val Thr Leu Lys Arg Ala Leu Glu Ala Lys Glu 
                565                 570                 575     


Leu Ala Arg Gln His Leu Arg Asp Gln Leu Asp Glu Val Glu Lys Glu 
            580                 585                 590         


Thr Arg Ser Lys Leu Gln Glu Ile Asp Ile Phe Asn Asn Gln Leu Lys 
        595                 600                 605             


Glu Leu Arg Glu Ile His Asn Lys Gln Gln Leu Gln Lys Gln Lys Ser 
    610                 615                 620                 


Met Glu Ala Glu Arg Leu Lys Gln Lys Glu Gln Glu Arg Lys Ile Ile 
625                 630                 635                 640 


Glu Leu Glu Lys Gln Lys Glu Glu Ala Gln Arg Arg Ala Gln Glu Arg 
                645                 650                 655     


Asp Lys Gln Trp Leu Glu His Val Gln Gln Glu Asp Glu His Gln Arg 
            660                 665                 670         


Pro Arg Lys Leu His Glu Glu Glu Lys Leu Lys Arg Glu Glu Ser Val 
        675                 680                 685             


Lys Lys Lys Asp Gly Glu Glu Lys Gly Lys Gln Glu Ala Gln Asp Lys 
    690                 695                 700                 


Leu Gly Arg Leu Phe His Gln His Gln Glu Pro Ala Lys Pro Ala Val 
705                 710                 715                 720 


Gln Ala Pro Trp Ser Thr Ala Glu Lys Gly Pro Leu Thr Ile Ser Ala 
                725                 730                 735     


Gln Glu Asn Val Lys Val Val Tyr Tyr Arg Ala Leu Tyr Pro Phe Glu 
            740                 745                 750         


Ser Arg Ser His Asp Glu Ile Thr Ile Gln Pro Gly Asp Ile Val Met 
        755                 760                 765             


Val Lys Gly Glu Trp Val Asp Glu Ser Gln Thr Gly Glu Pro Gly Trp 
    770                 775                 780                 


Leu Gly Gly Glu Leu Lys Gly Lys Thr Gly Trp Phe Pro Ala Asn Tyr 
785                 790                 795                 800 


Ala Glu Lys Ile Pro Glu Asn Glu Val Pro Ala Pro Val Lys Pro Val 
                805                 810                 815     


Thr Asp Ser Thr Ser Ala Pro Ala Pro Lys Leu Ala Leu Arg Glu Thr 
            820                 825                 830         


Pro Ala Pro Leu Ala Val Thr Ser Ser Glu Pro Ser Thr Thr Pro Asn 
        835                 840                 845             


Asn Trp Ala Asp Phe Ser Ser Thr Trp Pro Thr Ser Thr Asn Glu Lys 
    850                 855                 860                 


Pro Glu Thr Asp Asn Trp Asp Ala Trp Ala Ala Gln Pro Ser Leu Thr 
865                 870                 875                 880 


Val Pro Ser Ala Gly Gln Leu Arg Gln Arg Ser Ala Phe Thr Pro Ala 
                885                 890                 895     


Thr Ala Thr Gly Ser Ser Pro Ser Pro Val Leu Gly Gln Gly Glu Lys 
            900                 905                 910         


Val Glu Gly Leu Gln Ala Gln Ala Leu Tyr Pro Trp Arg Ala Lys Lys 
        915                 920                 925             


Asp Asn His Leu Asn Phe Asn Lys Asn Asp Val Ile Thr Val Leu Glu 
    930                 935                 940                 


Gln Gln Asp Met Trp Trp Phe Gly Glu Val Gln Gly Gln Lys Gly Trp 
945                 950                 955                 960 


Phe Pro Lys Ser Tyr Val Lys Leu Ile Ser Gly Pro Ile Arg Lys Ser 
                965                 970                 975     


Thr Ser Met Asp Ser Gly Ser Ser Glu Ser Pro Ala Ser Leu Lys Arg 
            980                 985                 990         


Val Ala Ser Pro Ala Ala Lys Pro  Val Val Ser Gly Glu  Glu Phe Ile 
        995                 1000                 1005             


Ala Met  Tyr Thr Tyr Glu Ser  Ser Glu Gln Gly Asp  Leu Thr Phe 
    1010                 1015                 1020             


Gln Gln  Gly Asp Val Ile Leu  Val Thr Lys Lys Asp  Gly Asp Trp 
    1025                 1030                 1035             


Trp Thr  Gly Thr Val Gly Asp  Lys Ala Gly Val Phe  Pro Ser Asn 
    1040                 1045                 1050             


Tyr Val  Arg Leu Lys Asp Ser  Glu Gly Ser Gly Thr  Ala Gly Lys 
    1055                 1060                 1065             


Thr Gly  Ser Leu Gly Lys Lys  Pro Glu Ile Ala Gln  Val Ile Ala 
    1070                 1075                 1080             


Ser Tyr  Thr Ala Thr Gly Pro  Glu Gln Leu Thr Leu  Ala Pro Gly 
    1085                 1090                 1095             


Gln Leu  Ile Leu Ile Arg Lys  Lys Asn Pro Gly Gly  Trp Trp Glu 
    1100                 1105                 1110             


Gly Glu  Leu Gln Ala Arg Gly  Lys Lys Arg Gln Ile  Gly Trp Phe 
    1115                 1120                 1125             


Pro Ala  Asn Tyr Val Lys Leu  Leu Ser Pro Gly Thr  Ser Lys Ile 
    1130                 1135                 1140             


Thr Pro  Thr Glu Pro Pro Lys  Ser Thr Ala Leu Ala  Ala Val Cys 
    1145                 1150                 1155             


Gln Val  Ile Gly Met Tyr Asp  Tyr Thr Ala Gln Asn  Asp Asp Glu 
    1160                 1165                 1170             


Leu Ala  Phe Asn Lys Gly Gln  Ile Ile Asn Val Leu  Asn Lys Glu 
    1175                 1180                 1185             


Asp Pro  Asp Trp Trp Lys Gly  Glu Val Asn Gly Gln  Val Gly Leu 
    1190                 1195                 1200             


Phe Pro  Ser Asn Tyr Val Lys  Leu Thr Thr Asp Met  Asp Pro Ser 
    1205                 1210                 1215             


Gln Gln  Trp Cys Ser Asp Leu  His Leu Leu Asp Met  Leu Thr Pro 
    1220                 1225                 1230             


Thr Glu  Arg Lys Arg Gln Gly  Tyr Ile His Glu Leu  Ile Val Thr 
    1235                 1240                 1245             


Glu Glu  Asn Tyr Val Asn Asp  Leu Gln Leu Val Thr  Glu Ile Phe 
    1250                 1255                 1260             


Gln Lys  Pro Leu Met Glu Ser  Glu Leu Leu Thr Glu  Lys Glu Val 
    1265                 1270                 1275             


Ala Met  Ile Phe Val Asn Trp  Lys Glu Leu Ile Met  Cys Asn Ile 
    1280                 1285                 1290             


Lys Leu  Leu Lys Ala Leu Arg  Val Arg Lys Lys Met  Ser Gly Glu 
    1295                 1300                 1305             


Lys Met  Pro Val Lys Met Ile  Gly Asp Ile Leu Ser  Ala Gln Leu 
    1310                 1315                 1320             


Pro His  Met Gln Pro Tyr Ile  Arg Phe Cys Ser Arg  Gln Leu Asn 
    1325                 1330                 1335             


Gly Ala  Ala Leu Ile Gln Gln  Lys Thr Asp Glu Ala  Pro Asp Phe 
    1340                 1345                 1350             


Lys Glu  Phe Val Lys Arg Leu  Ala Met Asp Pro Arg  Cys Lys Gly 
    1355                 1360                 1365             


Met Pro  Leu Ser Ser Phe Ile  Leu Lys Pro Met Gln  Arg Val Thr 
    1370                 1375                 1380             


Arg Tyr  Pro Leu Ile Ile Lys  Asn Ile Leu Glu Asn  Thr Pro Glu 
    1385                 1390                 1395             


Asn His  Pro Asp His Ser His  Leu Lys His Ala Leu  Glu Lys Ala 
    1400                 1405                 1410             


Glu Glu  Leu Cys Ser Gln Val  Asn Glu Gly Val Arg  Glu Lys Glu 
    1415                 1420                 1425             


Asn Ser  Asp Arg Leu Glu Trp  Ile Gln Ala His Val  Gln Cys Glu 
    1430                 1435                 1440             


Gly Leu  Ser Glu Gln Leu Val  Phe Asn Ser Val Thr  Asn Cys Leu 
    1445                 1450                 1455             


Gly Pro  Arg Lys Phe Leu His  Ser Gly Lys Leu Tyr  Lys Ala Lys 
    1460                 1465                 1470             


Ser Asn  Lys Glu Leu Tyr Gly  Phe Leu Phe Asn Asp  Phe Leu Leu 
    1475                 1480                 1485             


Leu Thr  Gln Ile Thr Lys Pro  Leu Gly Ser Ser Gly  Thr Asp Lys 
    1490                 1495                 1500             


Val Phe  Ser Pro Lys Ser Asn  Leu Gln Tyr Lys Met  Tyr Lys Thr 
    1505                 1510                 1515             


Pro Ile  Phe Leu Asn Glu Val  Leu Val Lys Leu Pro  Thr Asp Pro 
    1520                 1525                 1530             


Ser Gly  Asp Glu Pro Ile Phe  His Ile Ser His Ile  Asp Arg Val 
    1535                 1540                 1545             


Tyr Thr  Leu Arg Ala Glu Ser  Ile Asn Glu Arg Thr  Ala Trp Val 
    1550                 1555                 1560             


Gln Lys  Ile Lys Ala Ala Ser  Glu Leu Tyr Ile Glu  Thr Glu Lys 
    1565                 1570                 1575             


Lys Lys  Arg Glu Lys Ala Tyr  Leu Val Arg Ser Gln  Arg Ala Thr 
    1580                 1585                 1590             


Gly Ile  Gly Arg Leu Met Val  Asn Val Val Glu Gly  Ile Glu Leu 
    1595                 1600                 1605             


Lys Pro  Cys Arg Ser His Gly  Lys Ser Asn Pro Tyr  Cys Glu Val 
    1610                 1615                 1620             


Thr Met  Gly Ser Gln Cys His  Ile Thr Lys Thr Ile  Gln Asp Thr 
    1625                 1630                 1635             


Leu Asn  Pro Lys Trp Asn Ser  Asn Cys Gln Phe Phe  Ile Arg Asp 
    1640                 1645                 1650             


Leu Glu  Gln Glu Val Leu Cys  Ile Thr Val Phe Glu  Arg Asp Gln 
    1655                 1660                 1665             


Phe Ser  Pro Asp Asp Phe Leu  Gly Arg Thr Glu Ile  Arg Val Ala 
    1670                 1675                 1680             


Asp Ile  Lys Lys Asp Gln Gly  Ser Lys Gly Pro Val  Thr Lys Cys 
    1685                 1690                 1695             


Leu Leu  Leu His Glu Val Pro  Thr Gly Glu Ile Val  Val Arg Leu 
    1700                 1705                 1710             


Asp Leu  Gln Leu Phe Asp Glu  Pro 
    1715                 1720     


<210>  2757
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  2757

Met Val Thr Leu Arg Lys Arg Thr Leu Lys Val Leu Thr Phe Leu Val 
1               5                   10                  15      


Leu Phe Ile Phe Leu Thr Ser Phe Phe Leu Asn Tyr Ser His Thr Met 
            20                  25                  30          


Val Ala Thr Thr Trp Phe Pro Lys Gln Met Val Leu Glu Leu Ser Glu 
        35                  40                  45              


Asn Leu Lys Arg Leu Ile Lys His Arg Pro Cys Thr Cys Thr His Cys 
    50                  55                  60                  


Ile Gly Gln Arg Lys Leu Ser Ala Trp Phe Asp Glu Arg Phe Asn Gln 
65                  70                  75                  80  


Thr Met Gln Pro Leu Leu Thr Ala Gln Asn Ala Leu Leu Glu Asp Asp 
                85                  90                  95      


Thr Tyr Arg Trp Trp Leu Arg Leu Gln Arg Glu Lys Lys Pro Asn Asn 
            100                 105                 110         


Leu Asn Asp Thr Ile Lys Glu Leu Phe Arg Val Val Pro Gly Asn Val 
        115                 120                 125             


Asp Pro Met Leu Glu Lys Arg Ser Val Gly Cys Arg Arg Cys Ala Val 
    130                 135                 140                 


Val Gly Asn Ser Gly Asn Leu Arg Glu Ser Ser Tyr Gly Pro Glu Ile 
145                 150                 155                 160 


Asp Ser His Asp Phe Val Leu Arg Met Asn Lys Ala Pro Thr Ala Gly 
                165                 170                 175     


Phe Glu Ala Asp Val Gly Thr Lys Thr Thr His His Leu Val Tyr Pro 
            180                 185                 190         


Glu Ser Phe Arg Glu Leu Gly Asp Asn Val Ser Met Ile Leu Val Pro 
        195                 200                 205             


Phe Lys Thr Ile Asp Leu Glu Trp Val Val Ser Ala Ile Thr Thr Gly 
    210                 215                 220                 


Thr Ile Ser His Thr Tyr Ile Pro Val Pro Ala Lys Ile Arg Val Lys 
225                 230                 235                 240 


Gln Asp Lys Ile Leu Ile Tyr His Pro Ala Phe Ile Lys Tyr Val Phe 
                245                 250                 255     


Asp Asn Trp Leu Gln Gly His Gly Arg Tyr Pro Ser Thr Gly Ile Leu 
            260                 265                 270         


Ser Val Ile Phe Ser Met His Val Cys Asp Glu Val Asp Leu Tyr Gly 
        275                 280                 285             


Phe Gly Ala Asp Ser Lys Gly Asn Trp His His Tyr Trp Glu Asn Asn 
    290                 295                 300                 


Pro Ser Ala Gly Ala Phe Arg Lys Thr Gly Val His Asp Ala Asp Phe 
305                 310                 315                 320 


Glu Ser Asn Val Thr Ala Thr Leu Ala Ser Ile Asn Lys Ile Arg Ile 
                325                 330                 335     


Phe Lys Gly Arg 
            340 


<210>  2758
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  2758

Met Ser Pro Cys Gly Arg Ala Arg Arg Gln Thr Ser Arg Gly Ala Met 
1               5                   10                  15      


Ala Val Leu Ala Trp Lys Phe Pro Arg Thr Arg Leu Pro Met Gly Ala 
            20                  25                  30          


Ser Ala Leu Cys Val Val Val Leu Cys Trp Leu Tyr Ile Phe Pro Val 
        35                  40                  45              


Tyr Arg Leu Pro Asn Glu Lys Glu Ile Val Gln Gly Val Leu Gln Gln 
    50                  55                  60                  


Gly Thr Ala Trp Arg Arg Asn Gln Thr Ala Ala Arg Ala Phe Arg Lys 
65                  70                  75                  80  


Gln Met Glu Asp Cys Cys Asp Pro Ala His Leu Phe Ala Met Thr Lys 
                85                  90                  95      


Met Asn Ser Pro Met Gly Lys Ser Met Trp Tyr Asp Gly Glu Phe Leu 
            100                 105                 110         


Tyr Ser Phe Thr Ile Asp Asn Ser Thr Tyr Ser Leu Phe Pro Gln Ala 
        115                 120                 125             


Thr Pro Phe Gln Leu Pro Leu Lys Lys Cys Ala Val Val Gly Asn Gly 
    130                 135                 140                 


Gly Ile Leu Lys Lys Ser Gly Cys Gly Arg Gln Ile Asp Glu Ala Asn 
145                 150                 155                 160 


Phe Val Met Arg Cys Asn Leu Pro Pro Leu Ser Ser Glu Tyr Thr Lys 
                165                 170                 175     


Asp Val Gly Ser Lys Ser Gln Leu Val Thr Ala Asn Pro Ser Ile Ile 
            180                 185                 190         


Arg Gln Arg Phe Gln Asn Leu Leu Trp Ser Arg Lys Thr Phe Val Asp 
        195                 200                 205             


Asn Met Lys Ile Tyr Asn His Ser Tyr Ile Tyr Met Pro Ala Phe Ser 
    210                 215                 220                 


Met Lys Thr Gly Thr Glu Pro Ser Leu Arg Val Tyr Tyr Thr Leu Ser 
225                 230                 235                 240 


Asp Val Gly Ala Asn Gln Thr Val Leu Phe Ala Asn Pro Asn Phe Leu 
                245                 250                 255     


Arg Ser Ile Gly Lys Phe Trp Lys Ser Arg Gly Ile His Ala Lys Arg 
            260                 265                 270         


Leu Ser Thr Gly Leu Phe Leu Val Ser Ala Ala Leu Gly Leu Cys Glu 
        275                 280                 285             


Glu Val Ala Ile Tyr Gly Phe Trp Pro Phe Ser Val Asn Met His Glu 
    290                 295                 300                 


Gln Pro Ile Ser His His Tyr Tyr Asp Asn Val Leu Pro Phe Ser Gly 
305                 310                 315                 320 


Phe His Ala Met Pro Glu Glu Phe Leu Gln Leu Trp Tyr Leu His Lys 
                325                 330                 335     


Ile Gly Ala Leu Arg Met Gln Leu Asp Pro Cys Glu Asp Thr Ser Leu 
            340                 345                 350         


Gln Pro Thr Ser 
        355     


<210>  2759
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  2759

Met Asp Pro Lys Gly Leu Leu Ser Leu Thr Phe Val Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Gly Ala Ser Tyr Gly Thr Gly Gly Arg Met Met Asn Cys 
            20                  25                  30          


Pro Lys Ile Leu Arg Gln Leu Gly Ser Lys Val Leu Leu Pro Leu Thr 
        35                  40                  45              


Tyr Glu Arg Ile Asn Lys Ser Met Asn Lys Ser Ile His Ile Val Val 
    50                  55                  60                  


Thr Met Ala Lys Ser Leu Glu Asn Ser Val Glu Asn Lys Ile Val Ser 
65                  70                  75                  80  


Leu Asp Pro Ser Glu Ala Gly Pro Pro Arg Tyr Leu Gly Asp Arg Tyr 
                85                  90                  95      


Lys Phe Tyr Leu Glu Asn Leu Thr Leu Gly Ile Arg Glu Ser Arg Lys 
            100                 105                 110         


Glu Asp Glu Gly Trp Tyr Leu Met Thr Leu Glu Lys Asn Val Ser Val 
        115                 120                 125             


Gln Arg Phe Cys Leu Gln Leu Arg Leu Tyr Glu Gln Val Ser Thr Pro 
    130                 135                 140                 


Glu Ile Lys Val Leu Asn Lys Thr Gln Glu Asn Gly Thr Cys Thr Leu 
145                 150                 155                 160 


Ile Leu Gly Cys Thr Val Glu Lys Gly Asp His Val Ala Tyr Ser Trp 
                165                 170                 175     


Ser Glu Lys Ala Gly Thr His Pro Leu Asn Pro Ala Asn Ser Ser His 
            180                 185                 190         


Leu Leu Ser Leu Thr Leu Gly Pro Gln His Ala Asp Asn Ile Tyr Ile 
        195                 200                 205             


Cys Thr Val Ser Asn Pro Ile Ser Asn Asn Ser Gln Thr Phe Ser Pro 
    210                 215                 220                 


Trp Pro Gly Cys Arg Thr Asp Pro Ser Glu Thr Lys Pro Trp Ala Val 
225                 230                 235                 240 


Tyr Ala Gly Leu Leu Gly Gly Val Ile Met Ile Leu Ile Met Val Val 
                245                 250                 255     


Ile Leu Gln Leu Arg Arg Arg Gly Lys Thr Asn His Tyr Gln Thr Thr 
            260                 265                 270         


Val Glu Lys Lys Ser Leu Thr Ile Tyr Ala Gln Val Gln Lys Pro Gly 
        275                 280                 285             


Pro Leu Gln Lys Lys Leu Asp Ser Phe Pro Ala Gln Asp Pro Cys Thr 
    290                 295                 300                 


Thr Ile Tyr Val Ala Ala Thr Glu Pro Val Pro Glu Ser Val Gln Glu 
305                 310                 315                 320 


Thr Asn Ser Ile Thr Val Tyr Ala Ser Val Thr Leu Pro Glu Ser 
                325                 330                 335 


<210>  2760
<211>  532
<212>  PRT
<213>  Homo sapiens

<400>  2760

Met Glu Lys Ser Asn Glu Thr Asn Gly Tyr Leu Asp Ser Ala Gln Ala 
1               5                   10                  15      


Gly Pro Ala Ala Gly Pro Gly Ala Pro Gly Thr Ala Ala Gly Arg Ala 
            20                  25                  30          


Arg Arg Cys Ala Gly Phe Leu Arg Arg Gln Ala Leu Val Leu Leu Thr 
        35                  40                  45              


Val Ser Gly Val Leu Ala Gly Ala Gly Leu Gly Ala Ala Leu Arg Gly 
    50                  55                  60                  


Leu Ser Leu Ser Arg Thr Gln Val Thr Tyr Leu Ala Phe Pro Gly Glu 
65                  70                  75                  80  


Met Leu Leu Arg Met Leu Arg Met Ile Ile Leu Pro Leu Val Val Cys 
                85                  90                  95      


Ser Leu Val Ser Gly Ala Ala Ser Leu Asp Ala Ser Cys Leu Gly Arg 
            100                 105                 110         


Leu Gly Gly Ile Ala Val Ala Tyr Phe Gly Leu Thr Thr Leu Ser Ala 
        115                 120                 125             


Ser Ala Leu Ala Val Ala Leu Ala Phe Ile Ile Lys Pro Gly Ser Gly 
    130                 135                 140                 


Ala Gln Thr Leu Gln Ser Ser Asp Leu Gly Leu Glu Asp Ser Gly Pro 
145                 150                 155                 160 


Pro Pro Val Pro Lys Glu Thr Val Asp Ser Phe Leu Asp Leu Ala Arg 
                165                 170                 175     


Asn Leu Phe Pro Ser Asn Leu Val Val Ala Ala Phe Arg Thr Tyr Ala 
            180                 185                 190         


Thr Asp Tyr Lys Val Val Thr Gln Asn Ser Ser Ser Gly Asn Val Thr 
        195                 200                 205             


His Glu Lys Ile Pro Ile Gly Thr Glu Ile Glu Gly Met Asn Ile Leu 
    210                 215                 220                 


Gly Leu Val Leu Phe Ala Leu Val Leu Gly Val Ala Leu Lys Lys Leu 
225                 230                 235                 240 


Gly Ser Glu Gly Glu Asp Leu Ile Arg Phe Phe Asn Ser Leu Asn Glu 
                245                 250                 255     


Ala Thr Met Val Leu Val Ser Trp Ile Met Trp Tyr Val Pro Val Gly 
            260                 265                 270         


Ile Met Phe Leu Val Gly Ser Lys Ile Val Glu Met Lys Asp Ile Ile 
        275                 280                 285             


Val Leu Val Thr Ser Leu Gly Lys Tyr Ile Phe Ala Ser Ile Leu Gly 
    290                 295                 300                 


His Val Ile His Gly Gly Ile Val Leu Pro Leu Ile Tyr Phe Val Phe 
305                 310                 315                 320 


Thr Arg Lys Asn Pro Phe Arg Phe Leu Leu Gly Leu Leu Ala Pro Phe 
                325                 330                 335     


Ala Thr Ala Phe Ala Thr Cys Ser Ser Ser Ala Thr Leu Pro Ser Met 
            340                 345                 350         


Met Lys Cys Ile Glu Glu Asn Asn Gly Val Asp Lys Arg Ile Ser Arg 
        355                 360                 365             


Phe Ile Leu Pro Ile Gly Ala Thr Val Asn Met Asp Gly Ala Ala Ile 
    370                 375                 380                 


Phe Gln Cys Val Ala Ala Val Phe Ile Ala Gln Leu Asn Asn Val Glu 
385                 390                 395                 400 


Leu Asn Ala Gly Gln Ile Phe Thr Ile Leu Val Thr Ala Thr Ala Ser 
                405                 410                 415     


Ser Val Gly Ala Ala Gly Val Pro Ala Gly Gly Val Leu Thr Ile Ala 
            420                 425                 430         


Ile Ile Leu Glu Ala Ile Gly Leu Pro Thr His Asp Leu Pro Leu Ile 
        435                 440                 445             


Leu Ala Val Asp Trp Ile Val Asp Arg Thr Thr Thr Val Val Asn Val 
    450                 455                 460                 


Glu Gly Asp Ala Leu Gly Ala Gly Ile Leu His His Leu Asn Gln Lys 
465                 470                 475                 480 


Ala Thr Lys Lys Gly Glu Gln Glu Leu Ala Glu Val Lys Val Glu Ala 
                485                 490                 495     


Ile Pro Asn Cys Lys Ser Glu Glu Glu Thr Ser Pro Leu Val Thr His 
            500                 505                 510         


Gln Asn Pro Ala Gly Pro Val Ala Ser Ala Pro Glu Leu Glu Ser Lys 
        515                 520                 525             


Glu Ser Val Leu 
    530         


<210>  2761
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  2761

Met Glu Gln Gln Asp Gln Ser Met Lys Glu Gly Arg Leu Thr Leu Val 
1               5                   10                  15      


Leu Ala Leu Ala Thr Leu Ile Ala Ala Phe Gly Ser Ser Phe Gln Tyr 
            20                  25                  30          


Gly Tyr Asn Val Ala Ala Val Asn Ser Pro Ala Leu Leu Met Gln Gln 
        35                  40                  45              


Phe Tyr Asn Glu Thr Tyr Tyr Gly Arg Thr Gly Glu Phe Met Glu Asp 
    50                  55                  60                  


Phe Pro Leu Thr Leu Leu Trp Ser Val Thr Val Ser Met Phe Pro Phe 
65                  70                  75                  80  


Gly Gly Phe Ile Gly Ser Leu Leu Val Gly Pro Leu Val Asn Lys Phe 
                85                  90                  95      


Gly Arg Lys Gly Ala Leu Leu Phe Asn Asn Ile Phe Ser Ile Val Pro 
            100                 105                 110         


Ala Ile Leu Met Gly Cys Ser Arg Val Ala Thr Ser Phe Glu Leu Ile 
        115                 120                 125             


Ile Ile Ser Arg Leu Leu Val Gly Ile Cys Ala Gly Val Ser Ser Asn 
    130                 135                 140                 


Val Val Pro Met Tyr Leu Gly Glu Leu Ala Pro Lys Asn Leu Arg Gly 
145                 150                 155                 160 


Ala Leu Gly Val Val Pro Gln Leu Phe Ile Thr Val Gly Ile Leu Val 
                165                 170                 175     


Ala Gln Ile Phe Gly Leu Arg Asn Leu Leu Ala Asn Val Asp Gly Trp 
            180                 185                 190         


Pro Ile Leu Leu Gly Leu Thr Gly Val Pro Ala Ala Leu Gln Leu Leu 
        195                 200                 205             


Leu Leu Pro Phe Phe Pro Glu Ser Pro Arg Tyr Leu Leu Ile Gln Lys 
    210                 215                 220                 


Lys Asp Glu Ala Ala Ala Lys Lys Ala Leu Gln Thr Leu Arg Gly Trp 
225                 230                 235                 240 


Asp Ser Val Asp Arg Glu Val Ala Glu Ile Arg Gln Glu Asp Glu Ala 
                245                 250                 255     


Glu Lys Ala Ala Gly Phe Ile Ser Val Leu Lys Leu Phe Arg Met Arg 
            260                 265                 270         


Ser Leu Arg Trp Gln Leu Leu Ser Ile Ile Val Leu Met Gly Gly Gln 
        275                 280                 285             


Gln Leu Ser Gly Val Asn Ala Ile Tyr Tyr Tyr Ala Asp Gln Ile Tyr 
    290                 295                 300                 


Leu Ser Ala Gly Val Pro Glu Glu His Val Gln Tyr Val Thr Ala Gly 
305                 310                 315                 320 


Thr Gly Ala Val Asn Val Val Met Thr Phe Cys Ala Val Phe Val Val 
                325                 330                 335     


Glu Leu Leu Gly Arg Arg Leu Leu Leu Leu Leu Gly Phe Ser Ile Cys 
            340                 345                 350         


Leu Ile Ala Cys Cys Val Leu Thr Ala Ala Leu Ala Leu Gln Asp Thr 
        355                 360                 365             


Val Ser Trp Met Pro Tyr Ile Ser Ile Val Cys Val Ile Ser Tyr Val 
    370                 375                 380                 


Ile Gly His Ala Leu Gly Pro Ser Pro Ile Pro Ala Leu Leu Ile Thr 
385                 390                 395                 400 


Glu Ile Phe Leu Gln Ser Ser Arg Pro Ser Ala Phe Met Val Gly Gly 
                405                 410                 415     


Ser Val His Trp Leu Ser Asn Phe Thr Val Gly Leu Ile Phe Pro Phe 
            420                 425                 430         


Ile Gln Glu Gly Leu Gly Pro Tyr Ser Phe Ile Val Phe Ala Val Ile 
        435                 440                 445             


Cys Leu Leu Thr Thr Ile Tyr Ile Phe Leu Ile Val Pro Glu Thr Lys 
    450                 455                 460                 


Ala Lys Thr Phe Ile Glu Ile Asn Gln Ile Phe Thr Lys Met Asn Lys 
465                 470                 475                 480 


Val Ser Glu Val Tyr Pro Glu Lys Glu Glu Leu Lys Glu Leu Pro Pro 
                485                 490                 495     


Val Thr Ser Glu Gln 
            500     


<210>  2762
<211>  1241
<212>  PRT
<213>  Homo sapiens

<400>  2762

Met Ser Ser Ala Pro Arg Arg Pro Ala Lys Gly Ala Asp Ser Phe Cys 
1               5                   10                  15      


Thr Pro Glu Pro Glu Ser Leu Gly Pro Gly Thr Pro Gly Phe Pro Glu 
            20                  25                  30          


Gln Glu Glu Asp Glu Leu His Arg Thr Leu Gly Val Glu Arg Phe Glu 
        35                  40                  45              


Glu Ile Leu Gln Glu Ala Gly Ser Arg Gly Gly Glu Glu Pro Gly Arg 
    50                  55                  60                  


Ser Tyr Gly Glu Glu Asp Phe Glu Tyr His Arg Gln Ser Ser His His 
65                  70                  75                  80  


Ile His His Pro Leu Ser Thr His Leu Pro Pro Asp Ala Arg Arg Arg 
                85                  90                  95      


Lys Thr Pro Gln Gly Pro Gly Arg Lys Pro Arg Arg Arg Pro Gly Ala 
            100                 105                 110         


Ser Pro Thr Gly Glu Thr Pro Thr Ile Glu Glu Gly Glu Glu Asp Glu 
        115                 120                 125             


Asp Glu Ala Ser Glu Ala Glu Gly Ala Arg Ala Leu Thr Gln Pro Ser 
    130                 135                 140                 


Pro Val Ser Thr Pro Ser Ser Val Gln Phe Phe Leu Gln Glu Asp Asp 
145                 150                 155                 160 


Ser Ala Asp Arg Lys Ala Glu Arg Thr Ser Pro Ser Ser Pro Ala Pro 
                165                 170                 175     


Leu Pro His Gln Glu Ala Thr Pro Arg Ala Ser Lys Gly Ala Gln Ala 
            180                 185                 190         


Gly Thr Gln Val Glu Glu Ala Glu Ala Glu Ala Val Ala Val Ala Ser 
        195                 200                 205             


Gly Thr Ala Gly Gly Asp Asp Gly Gly Ala Ser Gly Arg Pro Leu Pro 
    210                 215                 220                 


Lys Ala Gln Pro Gly His Arg Ser Tyr Asn Leu Gln Glu Arg Arg Arg 
225                 230                 235                 240 


Ile Gly Ser Met Thr Gly Ala Glu Gln Ala Leu Leu Pro Arg Val Pro 
                245                 250                 255     


Thr Asp Glu Ile Glu Ala Gln Thr Leu Ala Thr Ala Asp Leu Asp Leu 
            260                 265                 270         


Met Lys Ser His Arg Phe Glu Asp Val Pro Gly Val Arg Arg His Leu 
        275                 280                 285             


Val Arg Lys Asn Ala Lys Gly Ser Thr Gln Ser Gly Arg Glu Gly Arg 
    290                 295                 300                 


Glu Pro Gly Pro Thr Pro Arg Ala Arg Pro Arg Ala Pro His Lys Pro 
305                 310                 315                 320 


His Glu Val Phe Val Glu Leu Asn Glu Leu Leu Leu Asp Lys Asn Gln 
                325                 330                 335     


Glu Pro Gln Trp Arg Glu Thr Ala Arg Trp Ile Lys Phe Glu Glu Asp 
            340                 345                 350         


Val Glu Glu Glu Thr Glu Arg Trp Gly Lys Pro His Val Ala Ser Leu 
        355                 360                 365             


Ser Phe Arg Ser Leu Leu Glu Leu Arg Arg Thr Leu Ala His Gly Ala 
    370                 375                 380                 


Val Leu Leu Asp Leu Asp Gln Gln Thr Leu Pro Gly Val Ala His Gln 
385                 390                 395                 400 


Val Val Glu Gln Met Val Ile Ser Asp Gln Ile Lys Ala Glu Asp Arg 
                405                 410                 415     


Ala Asn Val Leu Arg Ala Leu Leu Leu Lys His Ser His Pro Ser Asp 
            420                 425                 430         


Glu Lys Asp Phe Ser Phe Pro Arg Asn Ile Ser Ala Gly Ser Leu Gly 
        435                 440                 445             


Ser Leu Leu Gly His His His Gly Gln Gly Ala Glu Ser Asp Pro His 
    450                 455                 460                 


Val Thr Glu Pro Leu Met Gly Gly Val Pro Glu Thr Arg Leu Glu Val 
465                 470                 475                 480 


Glu Arg Glu Arg Glu Leu Pro Pro Pro Ala Pro Pro Ala Gly Ile Thr 
                485                 490                 495     


Arg Ser Lys Ser Lys His Glu Leu Lys Leu Leu Glu Lys Ile Pro Glu 
            500                 505                 510         


Asn Ala Glu Ala Thr Val Val Leu Val Gly Cys Val Glu Phe Leu Ser 
        515                 520                 525             


Arg Pro Thr Met Ala Phe Val Arg Leu Arg Glu Ala Val Glu Leu Asp 
    530                 535                 540                 


Ala Val Leu Glu Val Pro Val Pro Val Arg Phe Leu Phe Leu Leu Leu 
545                 550                 555                 560 


Gly Pro Ser Ser Ala Asn Met Asp Tyr His Glu Ile Gly Arg Ser Ile 
                565                 570                 575     


Ser Thr Leu Met Ser Asp Lys Gln Phe His Glu Ala Ala Tyr Leu Ala 
            580                 585                 590         


Asp Glu Arg Glu Asp Leu Leu Thr Ala Ile Asn Ala Phe Leu Asp Cys 
        595                 600                 605             


Ser Val Val Leu Pro Pro Ser Glu Val Gln Gly Glu Glu Leu Leu Arg 
    610                 615                 620                 


Ser Val Ala His Phe Gln Arg Gln Met Leu Lys Lys Arg Glu Glu Gln 
625                 630                 635                 640 


Gly Arg Leu Leu Pro Thr Gly Ala Gly Leu Glu Pro Lys Ser Ala Gln 
                645                 650                 655     


Asp Lys Ala Leu Leu Gln Met Val Glu Ala Ala Gly Ala Ala Glu Asp 
            660                 665                 670         


Asp Pro Leu Arg Arg Thr Gly Arg Pro Phe Gly Gly Leu Ile Arg Asp 
        675                 680                 685             


Val Arg Arg Arg Tyr Pro His Tyr Leu Ser Asp Phe Arg Asp Ala Leu 
    690                 695                 700                 


Asp Pro Gln Cys Leu Ala Ala Val Ile Phe Ile Tyr Phe Ala Ala Leu 
705                 710                 715                 720 


Ser Pro Ala Ile Thr Phe Gly Gly Leu Leu Gly Glu Lys Thr Gln Asp 
                725                 730                 735     


Leu Ile Gly Val Ser Glu Leu Ile Met Ser Thr Ala Leu Gln Gly Val 
            740                 745                 750         


Val Phe Cys Leu Leu Gly Ala Gln Pro Leu Leu Val Ile Gly Phe Ser 
        755                 760                 765             


Gly Pro Leu Leu Val Phe Glu Glu Ala Phe Phe Ser Phe Cys Ser Ser 
    770                 775                 780                 


Asn His Leu Glu Tyr Leu Val Gly Arg Val Trp Ile Gly Phe Trp Leu 
785                 790                 795                 800 


Val Phe Leu Ala Leu Leu Met Val Ala Leu Glu Gly Ser Phe Leu Val 
                805                 810                 815     


Arg Phe Val Ser Arg Phe Thr Gln Glu Ile Phe Ala Phe Leu Ile Ser 
            820                 825                 830         


Leu Ile Phe Ile Tyr Glu Thr Phe Tyr Lys Leu Val Lys Ile Phe Gln 
        835                 840                 845             


Glu His Pro Leu His Gly Cys Ser Ala Ser Asn Ser Ser Glu Val Asp 
    850                 855                 860                 


Gly Gly Glu Asn Met Thr Trp Ala Gly Ala Arg Pro Thr Leu Gly Pro 
865                 870                 875                 880 


Gly Asn Arg Ser Leu Ala Gly Gln Ser Gly Gln Gly Lys Pro Arg Gly 
                885                 890                 895     


Gln Pro Asn Thr Ala Leu Leu Ser Leu Val Leu Met Ala Gly Thr Phe 
            900                 905                 910         


Phe Ile Ala Phe Phe Leu Arg Lys Phe Lys Asn Ser Arg Phe Phe Pro 
        915                 920                 925             


Gly Arg Ile Arg Arg Val Ile Gly Asp Phe Gly Val Pro Ile Ala Ile 
    930                 935                 940                 


Leu Ile Met Val Leu Val Asp Tyr Ser Ile Glu Asp Thr Tyr Thr Gln 
945                 950                 955                 960 


Lys Leu Ser Val Pro Ser Gly Phe Ser Val Thr Ala Pro Glu Lys Arg 
                965                 970                 975     


Gly Trp Val Ile Asn Pro Leu Gly Glu Lys Ser Pro Phe Pro Val Trp 
            980                 985                 990         


Met Met Val Ala Ser Leu Leu Pro  Ala Ile Leu Val Phe  Ile Leu Ile 
        995                 1000                 1005             


Phe Met  Glu Thr Gln Ile Thr  Thr Leu Ile Ile Ser  Lys Lys Glu 
    1010                 1015                 1020             


Arg Met  Leu Gln Lys Gly Ser  Gly Phe His Leu Asp  Leu Leu Leu 
    1025                 1030                 1035             


Ile Val  Ala Met Gly Gly Ile  Cys Ala Leu Phe Gly  Leu Pro Trp 
    1040                 1045                 1050             


Leu Ala  Ala Ala Thr Val Arg  Ser Val Thr His Ala  Asn Ala Leu 
    1055                 1060                 1065             


Thr Val  Met Ser Lys Ala Val  Ala Pro Gly Asp Lys  Pro Lys Ile 
    1070                 1075                 1080             


Gln Glu  Val Lys Glu Gln Arg  Val Thr Gly Leu Leu  Val Ala Leu 
    1085                 1090                 1095             


Leu Val  Gly Leu Ser Ile Val  Ile Gly Asp Leu Leu  Arg Gln Ile 
    1100                 1105                 1110             


Pro Leu  Ala Val Leu Phe Gly  Ile Phe Leu Tyr Met  Gly Val Thr 
    1115                 1120                 1125             


Ser Leu  Asn Gly Ile Gln Phe  Tyr Glu Arg Leu His  Leu Leu Leu 
    1130                 1135                 1140             


Met Pro  Pro Lys His His Pro  Asp Val Thr Tyr Val  Lys Lys Val 
    1145                 1150                 1155             


Arg Thr  Leu Arg Met His Leu  Phe Thr Ala Leu Gln  Leu Leu Cys 
    1160                 1165                 1170             


Leu Ala  Leu Leu Trp Ala Val  Met Ser Thr Ala Ala  Ser Leu Ala 
    1175                 1180                 1185             


Phe Pro  Phe Ile Leu Ile Leu  Thr Val Pro Leu Arg  Met Val Val 
    1190                 1195                 1200             


Leu Thr  Arg Ile Phe Thr Asp  Arg Glu Met Lys Cys  Leu Asp Ala 
    1205                 1210                 1215             


Asn Glu  Ala Glu Pro Val Phe  Asp Glu Arg Glu Gly  Val Asp Glu 
    1220                 1225                 1230             


Tyr Asn  Glu Met Pro Met Pro  Val 
    1235                 1240     


<210>  2763
<211>  672
<212>  PRT
<213>  Homo sapiens

<400>  2763

Met Glu Glu His Thr Glu Ala Gly Ser Ala Pro Glu Met Gly Ala Gln 
1               5                   10                  15      


Lys Ala Leu Ile Asp Asn Pro Ala Asp Ile Leu Val Ile Ala Ala Tyr 
            20                  25                  30          


Phe Leu Leu Val Ile Gly Val Gly Leu Trp Ser Met Cys Arg Thr Asn 
        35                  40                  45              


Arg Gly Thr Val Gly Gly Tyr Phe Leu Ala Gly Arg Ser Met Val Trp 
    50                  55                  60                  


Trp Pro Val Gly Ala Ser Leu Phe Ala Ser Asn Ile Gly Ser Gly His 
65                  70                  75                  80  


Phe Val Gly Leu Ala Gly Thr Gly Ala Ala Ser Gly Leu Ala Val Ala 
                85                  90                  95      


Gly Phe Glu Trp Asn Ala Leu Phe Val Val Leu Leu Leu Gly Trp Leu 
            100                 105                 110         


Phe Ala Pro Val Tyr Leu Thr Ala Gly Val Ile Thr Met Pro Gln Tyr 
        115                 120                 125             


Leu Arg Lys Arg Phe Gly Gly Arg Arg Ile Arg Leu Tyr Leu Ser Val 
    130                 135                 140                 


Leu Ser Leu Phe Leu Tyr Ile Phe Thr Lys Ile Ser Val Asp Met Phe 
145                 150                 155                 160 


Ser Gly Ala Val Phe Ile Gln Gln Ala Leu Gly Trp Asn Ile Tyr Ala 
                165                 170                 175     


Ser Val Ile Ala Leu Leu Gly Ile Thr Met Ile Tyr Thr Val Thr Gly 
            180                 185                 190         


Gly Leu Ala Ala Leu Met Tyr Thr Asp Thr Val Gln Thr Phe Val Ile 
        195                 200                 205             


Leu Gly Gly Ala Cys Ile Leu Met Gly Tyr Ala Phe His Glu Val Gly 
    210                 215                 220                 


Gly Tyr Ser Gly Leu Phe Asp Lys Tyr Leu Gly Ala Ala Thr Ser Leu 
225                 230                 235                 240 


Thr Val Ser Glu Asp Pro Ala Val Gly Asn Ile Ser Ser Phe Cys Tyr 
                245                 250                 255     


Arg Pro Arg Pro Asp Ser Tyr His Leu Leu Arg His Pro Val Thr Gly 
            260                 265                 270         


Asp Leu Pro Trp Pro Ala Leu Leu Leu Gly Leu Thr Ile Val Ser Gly 
        275                 280                 285             


Trp Tyr Trp Cys Ser Asp Gln Val Ile Val Gln Arg Cys Leu Ala Gly 
    290                 295                 300                 


Lys Ser Leu Thr His Ile Lys Ala Gly Cys Ile Leu Cys Gly Tyr Leu 
305                 310                 315                 320 


Lys Leu Thr Pro Met Phe Leu Met Val Met Pro Gly Met Ile Ser Arg 
                325                 330                 335     


Ile Leu Tyr Pro Asp Glu Val Ala Cys Val Val Pro Glu Val Cys Arg 
            340                 345                 350         


Arg Val Cys Gly Thr Glu Val Gly Cys Ser Asn Ile Ala Tyr Pro Arg 
        355                 360                 365             


Leu Val Val Lys Leu Met Pro Asn Gly Leu Arg Gly Leu Met Leu Ala 
    370                 375                 380                 


Val Met Leu Ala Ala Leu Met Ser Ser Leu Ala Ser Ile Phe Asn Ser 
385                 390                 395                 400 


Ser Ser Thr Leu Phe Thr Met Asp Ile Tyr Thr Arg Leu Arg Pro Arg 
                405                 410                 415     


Ala Gly Asp Arg Glu Leu Leu Leu Val Gly Arg Leu Trp Val Val Phe 
            420                 425                 430         


Ile Val Val Val Ser Val Ala Trp Leu Pro Val Val Gln Ala Ala Gln 
        435                 440                 445             


Gly Gly Gln Leu Phe Asp Tyr Ile Gln Ala Val Ser Ser Tyr Leu Ala 
    450                 455                 460                 


Pro Pro Val Ser Ala Val Phe Val Leu Ala Leu Phe Val Pro Arg Val 
465                 470                 475                 480 


Asn Glu Gln Gly Ala Phe Trp Gly Leu Ile Gly Gly Leu Leu Met Gly 
                485                 490                 495     


Leu Ala Arg Leu Ile Pro Glu Phe Ser Phe Gly Ser Gly Ser Cys Val 
            500                 505                 510         


Gln Pro Ser Ala Cys Pro Ala Phe Leu Cys Gly Val His Tyr Leu Tyr 
        515                 520                 525             


Phe Ala Ile Val Leu Phe Phe Cys Ser Gly Leu Leu Thr Leu Thr Val 
    530                 535                 540                 


Ser Leu Cys Thr Ala Pro Ile Pro Arg Lys His Leu His Arg Leu Val 
545                 550                 555                 560 


Phe Ser Leu Arg His Ser Lys Glu Glu Arg Glu Asp Leu Asp Ala Asp 
                565                 570                 575     


Glu Gln Gln Gly Ser Ser Leu Pro Val Gln Asn Gly Cys Pro Glu Ser 
            580                 585                 590         


Ala Met Glu Met Asn Glu Pro Gln Ala Pro Ala Pro Ser Leu Phe Arg 
        595                 600                 605             


Gln Cys Leu Leu Trp Phe Cys Gly Met Ser Arg Gly Gly Val Gly Ser 
    610                 615                 620                 


Pro Pro Pro Leu Thr Gln Glu Glu Ala Ala Ala Ala Ala Arg Arg Leu 
625                 630                 635                 640 


Glu Asp Ile Ser Glu Asp Pro Ser Trp Ala Arg Val Val Asn Leu Asn 
                645                 650                 655     


Ala Leu Leu Met Met Ala Val Ala Val Phe Leu Trp Gly Phe Tyr Ala 
            660                 665                 670         


<210>  2764
<211>  599
<212>  PRT
<213>  Homo sapiens

<400>  2764

Met Ala Thr Asn Gly Ser Lys Val Ala Asp Gly Gln Ile Ser Thr Glu 
1               5                   10                  15      


Val Ser Glu Ala Pro Val Ala Asn Asp Lys Pro Lys Thr Leu Val Val 
            20                  25                  30          


Lys Val Gln Lys Lys Ala Ala Asp Leu Pro Asp Arg Asp Thr Trp Lys 
        35                  40                  45              


Gly Arg Phe Asp Phe Leu Met Ser Cys Val Gly Tyr Ala Ile Gly Leu 
    50                  55                  60                  


Gly Asn Val Trp Arg Phe Pro Tyr Leu Cys Gly Lys Asn Gly Gly Gly 
65                  70                  75                  80  


Ala Phe Leu Ile Pro Tyr Phe Leu Thr Leu Ile Phe Ala Gly Val Pro 
                85                  90                  95      


Leu Phe Leu Leu Glu Cys Ser Leu Gly Gln Tyr Thr Ser Ile Gly Gly 
            100                 105                 110         


Leu Gly Val Trp Lys Leu Ala Pro Met Phe Lys Gly Val Gly Leu Ala 
        115                 120                 125             


Ala Ala Val Leu Ser Phe Trp Leu Asn Ile Tyr Tyr Ile Val Ile Ile 
    130                 135                 140                 


Ser Trp Ala Ile Tyr Tyr Leu Tyr Asn Ser Phe Thr Thr Thr Leu Pro 
145                 150                 155                 160 


Trp Lys Gln Cys Asp Asn Pro Trp Asn Thr Asp Arg Cys Phe Ser Asn 
                165                 170                 175     


Tyr Ser Met Val Asn Thr Thr Asn Met Thr Ser Ala Val Val Glu Phe 
            180                 185                 190         


Trp Glu Arg Asn Met His Gln Met Thr Asp Gly Leu Asp Lys Pro Gly 
        195                 200                 205             


Gln Ile Arg Trp Pro Leu Ala Ile Thr Leu Ala Ile Ala Trp Ile Leu 
    210                 215                 220                 


Val Tyr Phe Cys Ile Trp Lys Gly Val Gly Trp Thr Gly Lys Val Val 
225                 230                 235                 240 


Tyr Phe Ser Ala Thr Tyr Pro Tyr Ile Met Leu Ile Ile Leu Phe Phe 
                245                 250                 255     


Arg Gly Val Thr Leu Pro Gly Ala Lys Glu Gly Ile Leu Phe Tyr Ile 
            260                 265                 270         


Thr Pro Asn Phe Arg Lys Leu Ser Asp Ser Glu Val Trp Leu Asp Ala 
        275                 280                 285             


Ala Thr Gln Ile Phe Phe Ser Tyr Gly Leu Gly Leu Gly Ser Leu Ile 
    290                 295                 300                 


Ala Leu Gly Ser Tyr Asn Ser Phe His Asn Asn Val Tyr Arg Asp Ser 
305                 310                 315                 320 


Ile Ile Val Cys Cys Ile Asn Ser Cys Thr Ser Met Phe Ala Gly Phe 
                325                 330                 335     


Val Ile Phe Ser Ile Val Gly Phe Met Ala His Val Thr Lys Arg Ser 
            340                 345                 350         


Ile Ala Asp Val Ala Ala Ser Gly Pro Gly Leu Ala Phe Leu Ala Tyr 
        355                 360                 365             


Pro Glu Ala Val Thr Gln Leu Pro Ile Ser Pro Leu Trp Ala Ile Leu 
    370                 375                 380                 


Phe Phe Ser Met Leu Leu Met Leu Gly Ile Asp Ser Gln Phe Cys Thr 
385                 390                 395                 400 


Val Glu Gly Phe Ile Thr Ala Leu Val Asp Glu Tyr Pro Arg Leu Leu 
                405                 410                 415     


Arg Asn Arg Arg Glu Leu Phe Ile Ala Ala Val Cys Ile Ile Ser Tyr 
            420                 425                 430         


Leu Ile Gly Leu Ser Asn Ile Thr Gln Gly Gly Ile Tyr Val Phe Lys 
        435                 440                 445             


Leu Phe Asp Tyr Tyr Ser Ala Ser Gly Met Ser Leu Leu Phe Leu Val 
    450                 455                 460                 


Phe Phe Glu Cys Val Ser Ile Ser Trp Phe Tyr Gly Val Asn Arg Phe 
465                 470                 475                 480 


Tyr Asp Asn Ile Gln Glu Met Val Gly Ser Arg Pro Cys Ile Trp Trp 
                485                 490                 495     


Lys Leu Cys Trp Ser Phe Phe Thr Pro Ile Ile Val Ala Gly Val Phe 
            500                 505                 510         


Ile Phe Ser Ala Val Gln Met Thr Pro Leu Thr Met Gly Asn Tyr Val 
        515                 520                 525             


Phe Pro Lys Trp Gly Gln Gly Val Gly Trp Leu Met Ala Leu Ser Ser 
    530                 535                 540                 


Met Val Leu Ile Pro Gly Tyr Met Ala Tyr Met Phe Leu Thr Leu Lys 
545                 550                 555                 560 


Gly Ser Leu Lys Gln Arg Ile Gln Val Met Val Gln Pro Ser Glu Asp 
                565                 570                 575     


Ile Val Arg Pro Glu Asn Gly Pro Glu Gln Pro Gln Ala Gly Ser Ser 
            580                 585                 590         


Thr Ser Lys Glu Ala Tyr Ile 
        595                 


<210>  2765
<211>  620
<212>  PRT
<213>  Homo sapiens

<400>  2765

Met Ala Thr Lys Glu Lys Leu Gln Cys Leu Lys Asp Phe His Lys Asp 
1               5                   10                  15      


Ile Leu Lys Pro Ser Pro Gly Lys Ser Pro Gly Thr Arg Pro Glu Asp 
            20                  25                  30          


Glu Ala Glu Gly Lys Pro Pro Gln Arg Glu Lys Trp Ser Ser Lys Ile 
        35                  40                  45              


Asp Phe Val Leu Ser Val Ala Gly Gly Phe Val Gly Leu Gly Asn Val 
    50                  55                  60                  


Trp Arg Phe Pro Tyr Leu Cys Tyr Lys Asn Gly Gly Gly Ala Phe Leu 
65                  70                  75                  80  


Ile Pro Tyr Phe Ile Phe Leu Phe Gly Ser Gly Leu Pro Val Phe Phe 
                85                  90                  95      


Leu Glu Ile Ile Ile Gly Gln Tyr Thr Ser Glu Gly Gly Ile Thr Cys 
            100                 105                 110         


Trp Glu Lys Ile Cys Pro Leu Phe Ser Gly Ile Gly Tyr Ala Ser Val 
        115                 120                 125             


Val Ile Val Ser Leu Leu Asn Val Tyr Tyr Ile Val Ile Leu Ala Trp 
    130                 135                 140                 


Ala Thr Tyr Tyr Leu Phe Gln Ser Phe Gln Lys Glu Leu Pro Trp Ala 
145                 150                 155                 160 


His Cys Asn His Ser Trp Asn Thr Pro His Cys Met Glu Asp Thr Met 
                165                 170                 175     


Arg Lys Asn Lys Ser Val Trp Ile Thr Ile Ser Ser Thr Asn Phe Thr 
            180                 185                 190         


Ser Pro Val Ile Glu Phe Trp Glu Arg Asn Val Leu Ser Leu Ser Pro 
        195                 200                 205             


Gly Ile Asp His Pro Gly Ser Leu Lys Trp Asp Leu Ala Leu Cys Leu 
    210                 215                 220                 


Leu Leu Val Trp Leu Val Cys Phe Phe Cys Ile Trp Lys Gly Val Arg 
225                 230                 235                 240 


Ser Thr Gly Lys Val Val Tyr Phe Thr Ala Thr Phe Pro Phe Ala Met 
                245                 250                 255     


Leu Leu Val Leu Leu Val Arg Gly Leu Thr Leu Pro Gly Ala Gly Ala 
            260                 265                 270         


Gly Ile Lys Phe Tyr Leu Tyr Pro Asp Ile Thr Arg Leu Glu Asp Pro 
        275                 280                 285             


Gln Val Trp Ile Asp Ala Gly Thr Gln Ile Phe Phe Ser Tyr Ala Ile 
    290                 295                 300                 


Cys Leu Gly Ala Met Thr Ser Leu Gly Ser Tyr Asn Lys Tyr Lys Tyr 
305                 310                 315                 320 


Asn Ser Tyr Arg Asp Cys Met Leu Leu Gly Cys Leu Asn Ser Gly Thr 
                325                 330                 335     


Ser Phe Val Ser Gly Phe Ala Ile Phe Ser Ile Leu Gly Phe Met Ala 
            340                 345                 350         


Gln Glu Gln Gly Val Asp Ile Ala Asp Val Ala Glu Ser Gly Pro Gly 
        355                 360                 365             


Leu Ala Phe Ile Ala Tyr Pro Lys Ala Val Thr Met Met Pro Leu Pro 
    370                 375                 380                 


Thr Phe Trp Ser Ile Leu Phe Phe Ile Met Leu Leu Leu Leu Gly Leu 
385                 390                 395                 400 


Asp Ser Gln Phe Val Glu Val Glu Gly Gln Ile Thr Ser Leu Val Asp 
                405                 410                 415     


Leu Tyr Pro Ser Phe Leu Arg Lys Gly Tyr Arg Arg Glu Ile Phe Ile 
            420                 425                 430         


Ala Phe Val Cys Ser Ile Ser Tyr Leu Leu Gly Leu Thr Met Val Thr 
        435                 440                 445             


Glu Gly Gly Met Tyr Val Phe Gln Leu Phe Asp Tyr Tyr Ala Ala Ser 
    450                 455                 460                 


Gly Val Cys Leu Leu Trp Val Ala Phe Phe Glu Cys Phe Val Ile Ala 
465                 470                 475                 480 


Trp Ile Tyr Gly Gly Asp Asn Leu Tyr Asp Gly Ile Glu Asp Met Ile 
                485                 490                 495     


Gly Tyr Arg Pro Gly Pro Trp Met Lys Tyr Ser Trp Ala Val Ile Thr 
            500                 505                 510         


Pro Val Leu Cys Val Gly Cys Phe Ile Phe Ser Leu Val Lys Tyr Val 
        515                 520                 525             


Pro Leu Thr Tyr Asn Lys Thr Tyr Val Tyr Pro Asn Trp Ala Ile Gly 
    530                 535                 540                 


Leu Gly Trp Ser Leu Ala Leu Ser Ser Met Leu Cys Val Pro Leu Val 
545                 550                 555                 560 


Ile Val Ile Arg Leu Cys Gln Thr Glu Gly Pro Phe Leu Val Arg Val 
                565                 570                 575     


Lys Tyr Leu Leu Thr Pro Arg Glu Pro Asn Arg Trp Ala Val Glu Arg 
            580                 585                 590         


Glu Gly Ala Thr Pro Tyr Asn Ser Arg Thr Val Met Asn Gly Ala Leu 
        595                 600                 605             


Val Lys Pro Thr His Ile Ile Val Glu Thr Met Met 
    610                 615                 620 


<210>  2766
<211>  614
<212>  PRT
<213>  Homo sapiens

<400>  2766

Met Asp Gly Lys Val Ala Val Gln Glu Cys Gly Pro Pro Ala Val Ser 
1               5                   10                  15      


Trp Val Pro Glu Glu Gly Glu Lys Leu Asp Gln Glu Asp Glu Asp Gln 
            20                  25                  30          


Val Lys Asp Arg Gly Gln Trp Thr Asn Lys Met Glu Phe Val Leu Ser 
        35                  40                  45              


Val Ala Gly Glu Ile Ile Gly Leu Gly Asn Val Trp Arg Phe Pro Tyr 
    50                  55                  60                  


Leu Cys Tyr Lys Asn Gly Gly Gly Ala Phe Phe Ile Pro Tyr Phe Ile 
65                  70                  75                  80  


Phe Phe Phe Val Cys Gly Ile Pro Val Phe Phe Leu Glu Val Ala Leu 
                85                  90                  95      


Gly Gln Tyr Thr Ser Gln Gly Ser Val Thr Ala Trp Arg Lys Ile Cys 
            100                 105                 110         


Pro Leu Phe Gln Gly Ile Gly Leu Ala Ser Val Val Ile Glu Ser Tyr 
        115                 120                 125             


Leu Asn Val Tyr Tyr Ile Ile Ile Leu Ala Trp Ala Leu Phe Tyr Leu 
    130                 135                 140                 


Phe Ser Ser Phe Thr Ser Glu Leu Pro Trp Thr Thr Cys Asn Asn Phe 
145                 150                 155                 160 


Trp Asn Thr Glu His Cys Thr Asp Phe Leu Asn His Ser Gly Ala Gly 
                165                 170                 175     


Thr Val Thr Pro Phe Glu Asn Phe Thr Ser Pro Val Met Glu Phe Trp 
            180                 185                 190         


Glu Arg Arg Val Leu Gly Ile Thr Ser Gly Ile His Asp Leu Gly Ser 
        195                 200                 205             


Leu Arg Trp Glu Leu Ala Leu Cys Leu Leu Leu Ala Trp Val Ile Cys 
    210                 215                 220                 


Tyr Phe Cys Ile Trp Lys Gly Val Lys Ser Thr Gly Lys Val Val Tyr 
225                 230                 235                 240 


Phe Thr Ala Thr Phe Pro Tyr Leu Met Leu Val Ile Leu Leu Ile Arg 
                245                 250                 255     


Gly Val Thr Leu Pro Gly Ala Tyr Gln Gly Ile Ile Tyr Tyr Leu Lys 
            260                 265                 270         


Pro Asp Leu Phe Arg Leu Lys Asp Pro Gln Val Trp Met Asp Ala Gly 
        275                 280                 285             


Thr Gln Ile Phe Phe Ser Phe Ala Ile Cys Gln Gly Cys Leu Thr Ala 
    290                 295                 300                 


Leu Gly Ser Tyr Asn Lys Tyr His Asn Asn Cys Tyr Lys Asp Cys Ile 
305                 310                 315                 320 


Ala Leu Cys Phe Leu Asn Ser Ala Thr Ser Phe Val Ala Gly Phe Val 
                325                 330                 335     


Val Phe Ser Ile Leu Gly Phe Met Ser Gln Glu Gln Gly Val Pro Ile 
            340                 345                 350         


Ser Glu Val Ala Glu Ser Gly Pro Gly Leu Ala Phe Ile Ala Phe Pro 
        355                 360                 365             


Lys Ala Val Thr Met Met Pro Leu Ser Gln Leu Trp Ser Cys Leu Phe 
    370                 375                 380                 


Phe Ile Met Leu Ile Phe Leu Gly Leu Asp Ser Gln Phe Val Cys Val 
385                 390                 395                 400 


Glu Cys Leu Val Thr Ala Ser Ile Asp Met Phe Pro Arg Gln Leu Arg 
                405                 410                 415     


Lys Ser Gly Arg Arg Glu Leu Leu Ile Leu Thr Ile Ala Val Met Cys 
            420                 425                 430         


Tyr Leu Ile Gly Leu Phe Leu Val Thr Glu Gly Gly Met Tyr Ile Phe 
        435                 440                 445             


Gln Leu Phe Asp Tyr Tyr Ala Ser Ser Gly Ile Cys Leu Leu Phe Leu 
    450                 455                 460                 


Ser Leu Phe Glu Val Val Cys Ile Ser Trp Val Tyr Gly Ala Asp Arg 
465                 470                 475                 480 


Phe Tyr Asp Asn Ile Glu Asp Met Ile Gly Tyr Arg Pro Trp Pro Leu 
                485                 490                 495     


Val Lys Ile Ser Trp Leu Phe Leu Thr Pro Gly Leu Cys Leu Ala Thr 
            500                 505                 510         


Phe Leu Phe Ser Leu Ser Lys Tyr Thr Pro Leu Lys Tyr Asn Asn Val 
        515                 520                 525             


Tyr Val Tyr Pro Pro Trp Gly Tyr Ser Ile Gly Trp Phe Leu Ala Leu 
    530                 535                 540                 


Ser Ser Met Val Cys Val Pro Leu Phe Val Val Ile Thr Leu Leu Lys 
545                 550                 555                 560 


Thr Arg Gly Pro Phe Arg Lys Arg Leu Arg Gln Leu Ile Thr Pro Asp 
                565                 570                 575     


Ser Ser Leu Pro Gln Pro Lys Gln His Pro Cys Leu Asp Gly Ser Ala 
            580                 585                 590         


Gly Arg Asn Phe Gly Pro Ser Pro Thr Arg Glu Gly Leu Ile Ala Gly 
        595                 600                 605             


Glu Lys Glu Thr His Leu 
    610                 


<210>  2767
<211>  629
<212>  PRT
<213>  Homo sapiens

<400>  2767

Met Gly Cys Lys Val Leu Leu Asn Ile Gly Gln Gln Met Leu Arg Arg 
1               5                   10                  15      


Lys Val Val Asp Cys Ser Arg Glu Glu Thr Arg Leu Ser Arg Cys Leu 
            20                  25                  30          


Asn Thr Phe Asp Leu Val Ala Leu Gly Val Gly Ser Thr Leu Gly Ala 
        35                  40                  45              


Gly Val Tyr Val Leu Ala Gly Ala Val Ala Arg Glu Asn Ala Gly Pro 
    50                  55                  60                  


Ala Ile Val Ile Ser Phe Leu Ile Ala Ala Leu Ala Ser Val Leu Ala 
65                  70                  75                  80  


Gly Leu Cys Tyr Gly Glu Phe Gly Ala Arg Val Pro Lys Thr Gly Ser 
                85                  90                  95      


Ala Tyr Leu Tyr Ser Tyr Val Thr Val Gly Glu Leu Trp Ala Phe Ile 
            100                 105                 110         


Thr Gly Trp Asn Leu Ile Leu Ser Tyr Ile Ile Gly Thr Ser Ser Val 
        115                 120                 125             


Ala Arg Ala Trp Ser Ala Thr Phe Asp Glu Leu Ile Gly Arg Pro Ile 
    130                 135                 140                 


Gly Glu Phe Ser Arg Thr His Met Thr Leu Asn Ala Pro Gly Val Leu 
145                 150                 155                 160 


Ala Glu Asn Pro Asp Ile Phe Ala Val Ile Ile Ile Leu Ile Leu Thr 
                165                 170                 175     


Gly Leu Leu Thr Leu Gly Val Lys Glu Ser Ala Met Val Asn Lys Ile 
            180                 185                 190         


Phe Thr Cys Ile Asn Val Leu Val Leu Gly Phe Ile Met Val Ser Gly 
        195                 200                 205             


Phe Val Lys Gly Ser Val Lys Asn Trp Gln Leu Thr Glu Glu Asp Phe 
    210                 215                 220                 


Gly Asn Thr Ser Gly Arg Leu Cys Leu Asn Asn Asp Thr Lys Glu Gly 
225                 230                 235                 240 


Lys Pro Gly Val Gly Gly Phe Met Pro Phe Gly Phe Ser Gly Val Leu 
                245                 250                 255     


Ser Gly Ala Ala Thr Cys Phe Tyr Ala Phe Val Gly Phe Asp Cys Ile 
            260                 265                 270         


Ala Thr Thr Gly Glu Glu Val Lys Asn Pro Gln Lys Ala Ile Pro Val 
        275                 280                 285             


Gly Ile Val Ala Ser Leu Leu Ile Cys Phe Ile Ala Tyr Phe Gly Val 
    290                 295                 300                 


Ser Ala Ala Leu Thr Leu Met Met Pro Tyr Phe Cys Leu Asp Asn Asn 
305                 310                 315                 320 


Ser Pro Leu Pro Asp Ala Phe Lys His Val Gly Trp Glu Gly Ala Lys 
                325                 330                 335     


Tyr Ala Val Ala Val Gly Ser Leu Cys Ala Leu Ser Ala Ser Leu Leu 
            340                 345                 350         


Gly Ser Met Phe Pro Met Pro Arg Val Ile Tyr Ala Met Ala Glu Asp 
        355                 360                 365             


Gly Leu Leu Phe Lys Phe Leu Ala Asn Val Asn Asp Arg Thr Lys Thr 
    370                 375                 380                 


Pro Ile Ile Ala Thr Leu Ala Ser Gly Ala Val Ala Ala Val Met Ala 
385                 390                 395                 400 


Phe Leu Phe Asp Leu Lys Asp Leu Val Asp Leu Met Ser Ile Gly Thr 
                405                 410                 415     


Leu Leu Ala Tyr Ser Leu Val Ala Ala Cys Val Leu Val Leu Arg Tyr 
            420                 425                 430         


Gln Pro Glu Gln Pro Asn Leu Val Tyr Gln Met Ala Ser Thr Ser Asp 
        435                 440                 445             


Glu Leu Asp Pro Ala Asp Gln Asn Glu Leu Ala Ser Thr Asn Asp Ser 
    450                 455                 460                 


Gln Leu Gly Phe Leu Pro Glu Ala Glu Met Phe Ser Leu Lys Thr Ile 
465                 470                 475                 480 


Leu Ser Pro Lys Asn Met Glu Pro Ser Lys Ile Ser Gly Leu Ile Val 
                485                 490                 495     


Asn Ile Ser Thr Ser Leu Ile Ala Val Leu Ile Ile Thr Phe Cys Ile 
            500                 505                 510         


Val Thr Val Leu Gly Arg Glu Ala Leu Thr Lys Gly Ala Leu Trp Ala 
        515                 520                 525             


Val Phe Leu Leu Ala Gly Ser Ala Leu Leu Cys Ala Val Val Thr Gly 
    530                 535                 540                 


Val Ile Trp Arg Gln Pro Glu Ser Lys Thr Lys Leu Ser Phe Lys Val 
545                 550                 555                 560 


Pro Phe Leu Pro Val Leu Pro Ile Leu Ser Ile Phe Val Asn Val Tyr 
                565                 570                 575     


Leu Met Met Gln Leu Asp Gln Gly Thr Trp Val Arg Phe Ala Val Trp 
            580                 585                 590         


Met Leu Ile Gly Phe Ile Ile Tyr Phe Gly Tyr Gly Leu Trp His Ser 
        595                 600                 605             


Glu Glu Ala Ser Leu Asp Ala Asp Gln Ala Arg Thr Pro Asp Gly Asn 
    610                 615                 620                 


Leu Asp Gln Cys Lys 
625                 


<210>  2768
<211>  697
<212>  PRT
<213>  Homo sapiens

<400>  2768

Met Lys Ile Glu Thr Ser Gly Tyr Asn Ser Asp Lys Leu Ile Cys Arg 
1               5                   10                  15      


Gly Phe Ile Gly Thr Pro Ala Pro Pro Val Cys Asp Ser Lys Phe Leu 
            20                  25                  30          


Leu Ser Pro Ser Ser Asp Val Arg Met Ile Pro Cys Arg Ala Ala Leu 
        35                  40                  45              


Thr Phe Ala Arg Cys Leu Ile Arg Arg Lys Ile Val Thr Leu Asp Ser 
    50                  55                  60                  


Leu Glu Asp Thr Lys Leu Cys Arg Cys Leu Ser Thr Met Asp Leu Ile 
65                  70                  75                  80  


Ala Leu Gly Val Gly Ser Thr Leu Gly Ala Gly Val Tyr Val Leu Ala 
                85                  90                  95      


Gly Glu Val Ala Lys Ala Asp Ser Gly Pro Ser Ile Val Val Ser Phe 
            100                 105                 110         


Leu Ile Ala Ala Leu Ala Ser Val Met Ala Gly Leu Cys Tyr Ala Glu 
        115                 120                 125             


Phe Gly Ala Arg Val Pro Lys Thr Gly Ser Ala Tyr Leu Tyr Thr Tyr 
    130                 135                 140                 


Val Thr Val Gly Glu Leu Trp Ala Phe Ile Thr Gly Trp Asn Leu Ile 
145                 150                 155                 160 


Leu Ser Tyr Val Ile Gly Thr Ser Ser Val Ala Arg Ala Trp Ser Gly 
                165                 170                 175     


Thr Phe Asp Glu Leu Leu Ser Lys Gln Ile Gly Gln Phe Leu Arg Thr 
            180                 185                 190         


Tyr Phe Arg Met Asn Tyr Thr Gly Leu Ala Glu Tyr Pro Asp Phe Phe 
        195                 200                 205             


Ala Val Cys Leu Ile Leu Leu Leu Ala Gly Leu Leu Ser Phe Gly Val 
    210                 215                 220                 


Lys Glu Ser Ala Trp Val Asn Lys Val Phe Thr Ala Val Asn Ile Leu 
225                 230                 235                 240 


Val Leu Leu Phe Val Met Val Ala Gly Phe Val Lys Gly Asn Val Ala 
                245                 250                 255     


Asn Trp Lys Ile Ser Glu Glu Phe Leu Lys Asn Ile Ser Ala Ser Ala 
            260                 265                 270         


Arg Glu Pro Pro Ser Glu Asn Gly Thr Ser Ile Tyr Gly Ala Gly Gly 
        275                 280                 285             


Phe Met Pro Tyr Gly Phe Thr Gly Thr Leu Ala Gly Ala Ala Thr Cys 
    290                 295                 300                 


Phe Tyr Ala Phe Val Gly Phe Asp Cys Ile Ala Thr Thr Gly Glu Glu 
305                 310                 315                 320 


Val Arg Asn Pro Gln Lys Ala Ile Pro Ile Gly Ile Val Thr Ser Leu 
                325                 330                 335     


Leu Val Cys Phe Met Ala Tyr Phe Gly Val Ser Ala Ala Leu Thr Leu 
            340                 345                 350         


Met Met Pro Tyr Tyr Leu Leu Asp Glu Lys Ser Pro Leu Pro Val Ala 
        355                 360                 365             


Phe Glu Tyr Val Gly Trp Gly Pro Ala Lys Tyr Val Val Ala Ala Gly 
    370                 375                 380                 


Ser Leu Cys Ala Leu Ser Thr Ser Leu Leu Gly Ser Met Phe Pro Leu 
385                 390                 395                 400 


Pro Arg Ile Leu Phe Ala Met Ala Arg Asp Gly Leu Leu Phe Arg Phe 
                405                 410                 415     


Leu Ala Arg Val Ser Lys Arg Gln Ser Pro Val Ala Ala Thr Leu Thr 
            420                 425                 430         


Ala Gly Val Ile Ser Ala Leu Met Ala Phe Leu Phe Asp Leu Lys Ala 
        435                 440                 445             


Leu Val Asp Met Met Ser Ile Gly Thr Leu Met Ala Tyr Ser Leu Val 
    450                 455                 460                 


Ala Ala Cys Val Leu Ile Leu Arg Tyr Gln Pro Gly Leu Ser Tyr Asp 
465                 470                 475                 480 


Gln Pro Lys Cys Ser Pro Glu Lys Asp Gly Leu Gly Ser Ser Pro Arg 
                485                 490                 495     


Val Thr Ser Lys Ser Glu Ser Gln Val Thr Met Leu Gln Arg Gln Gly 
            500                 505                 510         


Phe Ser Met Arg Thr Leu Phe Cys Pro Ser Leu Leu Pro Thr Gln Gln 
        515                 520                 525             


Ser Ala Ser Leu Val Ser Phe Leu Val Gly Phe Leu Ala Phe Leu Val 
    530                 535                 540                 


Leu Gly Leu Ser Val Leu Thr Thr Tyr Gly Val His Ala Ile Thr Arg 
545                 550                 555                 560 


Leu Glu Ala Trp Ser Leu Ala Leu Leu Ala Leu Phe Leu Val Leu Phe 
                565                 570                 575     


Val Ala Ile Val Leu Thr Ile Trp Arg Gln Pro Gln Asn Gln Gln Lys 
            580                 585                 590         


Val Ala Phe Met Val Pro Phe Leu Pro Phe Leu Pro Ala Phe Ser Ile 
        595                 600                 605             


Leu Val Asn Ile Tyr Leu Met Val Gln Leu Ser Ala Asp Thr Trp Val 
    610                 615                 620                 


Arg Phe Ser Ile Trp Met Ala Ile Gly Phe Leu Ile Tyr Phe Ser Tyr 
625                 630                 635                 640 


Gly Ile Arg His Ser Leu Glu Gly His Leu Arg Asp Glu Asn Asn Glu 
                645                 650                 655     


Glu Asp Ala Tyr Pro Asp Asn Val His Ala Ala Ala Glu Glu Lys Ser 
            660                 665                 670         


Ala Ile Gln Ala Asn Asp His His Pro Arg Asn Leu Ser Ser Pro Phe 
        675                 680                 685             


Ile Phe His Glu Lys Thr Ser Glu Phe 
    690                 695         


<210>  2769
<211>  812
<212>  PRT
<213>  Homo sapiens

<400>  2769

Met Glu Pro Leu Gly Asn Trp Arg Ser Leu Arg Ala Pro Leu Pro Pro 
1               5                   10                  15      


Met Leu Leu Leu Leu Leu Leu Gln Val Ala Gly Pro Val Gly Ala Leu 
            20                  25                  30          


Ala Glu Thr Leu Leu Asn Ala Pro Arg Ala Met Gly Thr Ser Ser Ser 
        35                  40                  45              


Pro Pro Ser Pro Ala Ser Val Val Ala Pro Gly Thr Thr Leu Phe Glu 
    50                  55                  60                  


Glu Ser Arg Leu Pro Val Phe Thr Leu Asp Tyr Pro His Val Gln Ile 
65                  70                  75                  80  


Pro Phe Glu Ile Thr Leu Trp Ile Leu Leu Ala Ser Leu Ala Lys Ile 
                85                  90                  95      


Gly Phe His Leu Tyr His Lys Leu Pro Thr Ile Val Pro Glu Ser Cys 
            100                 105                 110         


Leu Leu Ile Met Val Gly Leu Leu Leu Gly Gly Ile Ile Phe Gly Val 
        115                 120                 125             


Asp Glu Lys Ser Pro Pro Ala Met Lys Thr Asp Val Phe Phe Leu Tyr 
    130                 135                 140                 


Leu Leu Pro Pro Ile Val Leu Asp Ala Gly Tyr Phe Met Pro Thr Arg 
145                 150                 155                 160 


Pro Phe Phe Glu Asn Ile Gly Thr Ile Phe Trp Tyr Ala Val Val Gly 
                165                 170                 175     


Thr Leu Trp Asn Ser Ile Gly Ile Gly Val Ser Leu Phe Gly Ile Cys 
            180                 185                 190         


Gln Ile Glu Ala Phe Gly Leu Ser Asp Ile Thr Leu Leu Gln Asn Leu 
        195                 200                 205             


Leu Phe Gly Ser Leu Ile Ser Ala Val Asp Pro Val Ala Val Leu Ala 
    210                 215                 220                 


Val Phe Glu Asn Ile His Val Asn Glu Gln Leu Tyr Ile Leu Val Phe 
225                 230                 235                 240 


Gly Glu Ser Leu Leu Asn Asp Ala Val Thr Val Val Leu Tyr Asn Leu 
                245                 250                 255     


Phe Lys Ser Phe Cys Gln Met Lys Thr Ile Glu Thr Ile Asp Val Phe 
            260                 265                 270         


Ala Gly Ile Ala Asn Phe Phe Val Val Gly Ile Gly Gly Val Leu Ile 
        275                 280                 285             


Gly Ile Phe Leu Gly Phe Ile Ala Ala Phe Thr Thr Arg Phe Thr His 
    290                 295                 300                 


Asn Ile Arg Val Ile Glu Pro Leu Phe Val Phe Leu Tyr Ser Tyr Leu 
305                 310                 315                 320 


Ser Tyr Ile Thr Ala Glu Met Phe His Leu Ser Gly Ile Met Ala Ile 
                325                 330                 335     


Thr Ala Cys Ala Met Thr Met Asn Lys Tyr Val Glu Glu Asn Val Ser 
            340                 345                 350         


Gln Lys Ser Tyr Thr Thr Ile Lys Tyr Phe Met Lys Met Leu Ser Ser 
        355                 360                 365             


Val Ser Glu Thr Leu Ile Phe Ile Phe Met Gly Val Ser Thr Val Gly 
    370                 375                 380                 


Lys Asn His Glu Trp Asn Trp Ala Phe Val Cys Phe Thr Leu Ala Phe 
385                 390                 395                 400 


Cys Leu Met Trp Arg Ala Leu Gly Val Phe Val Leu Thr Gln Val Ile 
                405                 410                 415     


Asn Arg Phe Arg Thr Ile Pro Leu Thr Phe Lys Asp Gln Phe Ile Ile 
            420                 425                 430         


Ala Tyr Gly Gly Leu Arg Gly Ala Ile Cys Phe Ala Leu Val Phe Leu 
        435                 440                 445             


Leu Pro Ala Ala Val Phe Pro Arg Lys Lys Leu Phe Ile Thr Ala Ala 
    450                 455                 460                 


Ile Val Val Ile Phe Phe Thr Val Phe Ile Leu Gly Ile Thr Ile Arg 
465                 470                 475                 480 


Pro Leu Val Glu Phe Leu Asp Val Lys Arg Ser Asn Lys Lys Gln Gln 
                485                 490                 495     


Ala Val Ser Glu Glu Ile Tyr Cys Arg Leu Phe Asp His Val Lys Thr 
            500                 505                 510         


Gly Ile Glu Asp Val Cys Gly His Trp Gly His Asn Phe Trp Arg Asp 
        515                 520                 525             


Lys Phe Lys Lys Phe Asp Asp Lys Tyr Leu Arg Lys Leu Leu Ile Arg 
    530                 535                 540                 


Glu Asn Gln Pro Lys Ser Ser Ile Val Ser Leu Tyr Lys Lys Leu Glu 
545                 550                 555                 560 


Ile Lys His Ala Ile Glu Met Ala Glu Thr Gly Met Ile Ser Thr Val 
                565                 570                 575     


Pro Thr Phe Ala Ser Leu Asn Asp Cys Arg Glu Glu Lys Ile Arg Lys 
            580                 585                 590         


Val Thr Ser Ser Glu Thr Asp Glu Ile Arg Glu Leu Leu Ser Arg Asn 
        595                 600                 605             


Leu Tyr Gln Ile Arg Gln Arg Thr Leu Ser Tyr Asn Arg His Ser Leu 
    610                 615                 620                 


Thr Ala Asp Thr Ser Glu Arg Gln Ala Lys Glu Ile Leu Ile Arg Arg 
625                 630                 635                 640 


Arg His Ser Leu Arg Glu Ser Ile Arg Lys Asp Ser Ser Leu Asn Arg 
                645                 650                 655     


Glu His Arg Ala Ser Thr Ser Thr Ser Arg Tyr Leu Ser Leu Pro Lys 
            660                 665                 670         


Asn Thr Lys Leu Pro Glu Lys Leu Gln Lys Arg Arg Thr Ile Ser Ile 
        675                 680                 685             


Ala Asp Gly Asn Ser Ser Asp Ser Asp Ala Asp Ala Gly Thr Thr Val 
    690                 695                 700                 


Leu Asn Leu Gln Pro Arg Ala Arg Arg Phe Leu Pro Glu Gln Phe Ser 
705                 710                 715                 720 


Lys Lys Ser Pro Gln Ser Tyr Lys Met Glu Trp Lys Asn Glu Val Asp 
                725                 730                 735     


Val Asp Ser Gly Arg Asp Met Pro Ser Thr Pro Pro Thr Pro His Ser 
            740                 745                 750         


Arg Glu Lys Gly Thr Gln Thr Ser Gly Leu Leu Gln Gln Pro Leu Leu 
        755                 760                 765             


Ser Lys Asp Gln Ser Gly Ser Glu Arg Glu Asp Ser Leu Thr Glu Gly 
    770                 775                 780                 


Ile Pro Pro Lys Pro Pro Pro Arg Leu Val Trp Arg Ala Ser Glu Pro 
785                 790                 795                 800 


Gly Ser Arg Lys Ala Arg Phe Gly Ser Glu Lys Pro 
                805                 810         


<210>  2770
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  2770

Met Glu Ala His Asn Ala Ser Ala Pro Phe Asn Phe Thr Leu Pro Pro 
1               5                   10                  15      


Asn Phe Gly Lys Arg Pro Thr Asp Leu Ala Leu Ser Val Ile Leu Val 
            20                  25                  30          


Phe Met Leu Phe Phe Ile Met Leu Ser Leu Gly Cys Thr Met Glu Phe 
        35                  40                  45              


Ser Lys Ile Lys Ala His Leu Trp Lys Pro Lys Gly Leu Ala Ile Ala 
    50                  55                  60                  


Leu Val Ala Gln Tyr Gly Ile Met Pro Leu Thr Ala Phe Val Leu Gly 
65                  70                  75                  80  


Lys Val Phe Arg Leu Lys Asn Ile Glu Ala Leu Ala Ile Leu Val Cys 
                85                  90                  95      


Gly Cys Ser Pro Gly Gly Asn Leu Ser Asn Val Phe Ser Leu Ala Met 
            100                 105                 110         


Lys Gly Asp Met Asn Leu Ser Ile Val Met Thr Thr Cys Ser Thr Phe 
        115                 120                 125             


Cys Ala Leu Gly Met Met Pro Leu Leu Leu Tyr Ile Tyr Ser Arg Gly 
    130                 135                 140                 


Ile Tyr Asp Gly Asp Leu Lys Asp Lys Val Pro Tyr Lys Gly Ile Val 
145                 150                 155                 160 


Ile Ser Leu Val Leu Val Leu Ile Pro Cys Thr Ile Gly Ile Val Leu 
                165                 170                 175     


Lys Ser Lys Arg Pro Gln Tyr Met Arg Tyr Val Ile Lys Gly Gly Met 
            180                 185                 190         


Ile Ile Ile Leu Leu Cys Ser Val Ala Val Thr Val Leu Ser Ala Ile 
        195                 200                 205             


Asn Val Gly Lys Ser Ile Met Phe Ala Met Thr Pro Leu Leu Ile Ala 
    210                 215                 220                 


Thr Ser Ser Leu Met Pro Phe Ile Gly Phe Leu Leu Gly Tyr Val Leu 
225                 230                 235                 240 


Ser Ala Leu Phe Cys Leu Asn Gly Arg Cys Arg Arg Thr Val Ser Met 
                245                 250                 255     


Glu Thr Gly Cys Gln Asn Val Gln Leu Cys Ser Thr Ile Leu Asn Val 
            260                 265                 270         


Ala Phe Pro Pro Glu Val Ile Gly Pro Leu Phe Phe Phe Pro Leu Leu 
        275                 280                 285             


Tyr Met Ile Phe Gln Leu Gly Glu Gly Leu Leu Leu Ile Ala Ile Phe 
    290                 295                 300                 


Trp Cys Tyr Glu Lys Phe Lys Thr Pro Lys Asp Lys Thr Lys Met Ile 
305                 310                 315                 320 


Tyr Thr Ala Ala Thr Thr Glu Glu Thr Ile Pro Gly Ala Leu Gly Asn 
                325                 330                 335     


Gly Thr Tyr Lys Gly Glu Asp Cys Ser Pro Cys Thr Ala 
            340                 345                 


<210>  2771
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  2771

Met Pro Pro Ala Val Gly Gly Pro Val Gly Tyr Thr Pro Pro Asp Gly 
1               5                   10                  15      


Gly Trp Gly Trp Ala Val Val Ile Gly Ala Phe Ile Ser Ile Gly Phe 
            20                  25                  30          


Ser Tyr Ala Phe Pro Lys Ser Ile Thr Val Phe Phe Lys Glu Ile Glu 
        35                  40                  45              


Gly Ile Phe His Ala Thr Thr Ser Glu Val Ser Trp Ile Ser Ser Ile 
    50                  55                  60                  


Met Leu Ala Val Met Tyr Gly Gly Gly Pro Ile Ser Ser Ile Leu Val 
65                  70                  75                  80  


Asn Lys Tyr Gly Ser Arg Ile Val Met Ile Val Gly Gly Cys Leu Ser 
                85                  90                  95      


Gly Cys Gly Leu Ile Ala Ala Ser Phe Cys Asn Thr Val Gln Gln Leu 
            100                 105                 110         


Tyr Val Cys Ile Gly Val Ile Gly Gly Leu Gly Leu Ala Phe Asn Leu 
        115                 120                 125             


Asn Pro Ala Leu Thr Met Ile Gly Lys Tyr Phe Tyr Lys Arg Arg Pro 
    130                 135                 140                 


Leu Ala Asn Gly Leu Ala Met Ala Gly Ser Pro Val Phe Leu Cys Thr 
145                 150                 155                 160 


Leu Ala Pro Leu Asn Gln Val Phe Phe Gly Ile Phe Gly Trp Arg Gly 
                165                 170                 175     


Ser Phe Leu Ile Leu Gly Gly Leu Leu Leu Asn Cys Cys Val Ala Gly 
            180                 185                 190         


Ala Leu Met Arg Pro Ile Gly Pro Lys Pro Thr Lys Ala Gly Lys Asp 
        195                 200                 205             


Lys Ser Lys Ala Ser Leu Glu Lys Ala Gly Lys Ser Gly Val Lys Lys 
    210                 215                 220                 


Asp Leu His Asp Ala Asn Thr Asp Leu Ile Gly Arg His Pro Lys Gln 
225                 230                 235                 240 


Glu Lys Arg Ser Val Phe Gln Thr Ile Asn Gln Phe Leu Asp Leu Thr 
                245                 250                 255     


Leu Phe Thr His Arg Gly Phe Leu Leu Tyr Leu Ser Gly Asn Val Ile 
            260                 265                 270         


Met Phe Phe Gly Leu Phe Ala Pro Leu Val Phe Leu Ser Ser Tyr Gly 
        275                 280                 285             


Lys Ser Gln His Tyr Ser Ser Glu Lys Ser Ala Phe Leu Leu Ser Ile 
    290                 295                 300                 


Leu Ala Phe Val Asp Met Val Ala Arg Pro Ser Met Gly Leu Val Ala 
305                 310                 315                 320 


Asn Thr Lys Pro Ile Arg Pro Arg Ile Gln Tyr Phe Phe Ala Ala Ser 
                325                 330                 335     


Val Val Ala Asn Gly Val Cys His Met Leu Ala Pro Leu Ser Thr Thr 
            340                 345                 350         


Tyr Val Gly Phe Cys Val Tyr Ala Gly Phe Phe Gly Phe Ala Phe Gly 
        355                 360                 365             


Trp Leu Ser Ser Val Leu Phe Glu Thr Leu Met Asp Leu Val Gly Pro 
    370                 375                 380                 


Gln Arg Phe Ser Ser Ala Val Gly Leu Val Thr Ile Val Glu Cys Cys 
385                 390                 395                 400 


Pro Val Leu Leu Gly Pro Pro Leu Leu Gly Arg Leu Asn Asp Met Tyr 
                405                 410                 415     


Gly Asp Tyr Lys Tyr Thr Tyr Trp Ala Cys Gly Val Val Leu Ile Ile 
            420                 425                 430         


Ser Gly Ile Tyr Leu Phe Ile Gly Met Gly Ile Asn Tyr Arg Leu Leu 
        435                 440                 445             


Ala Lys Glu Gln Lys Ala Asn Glu Gln Lys Lys Glu Ser Lys Glu Glu 
    450                 455                 460                 


Glu Thr Ser Ile Asp Val Ala Gly Lys Pro Asn Glu Val Thr Lys Ala 
465                 470                 475                 480 


Ala Glu Ser Pro Asp Gln Lys Asp Thr Asp Gly Gly Pro Lys Glu Glu 
                485                 490                 495     


Glu Ser Pro Val 
            500 


<210>  2772
<211>  639
<212>  PRT
<213>  Homo sapiens

<400>  2772

Met Leu Ser Tyr Gly Glu Arg Leu Gly Ser Pro Ala Val Ser Pro Leu 
1               5                   10                  15      


Pro Val Arg Gly Gly His Val Met Arg Gly Thr Ala Phe Ala Tyr Val 
            20                  25                  30          


Pro Ser Pro Gln Val Leu His Arg Ile Pro Gly Thr Ser Ala Tyr Ala 
        35                  40                  45              


Phe Pro Ser Leu Gly Pro Val Ala Leu Ala Glu His Thr Cys Pro Cys 
    50                  55                  60                  


Gly Glu Val Leu Glu Arg His Glu Pro Leu Pro Ala Lys Leu Ala Leu 
65                  70                  75                  80  


Glu Glu Glu Gln Lys Pro Glu Ser Arg Leu Val Pro Lys Leu Arg Gln 
                85                  90                  95      


Ala Gly Ala Met Leu Leu Lys Val Pro Leu Met Leu Thr Phe Leu Tyr 
            100                 105                 110         


Leu Phe Val Cys Ser Leu Asp Met Leu Ser Ser Ala Phe Gln Leu Ala 
        115                 120                 125             


Gly Gly Lys Val Ala Gly Asp Ile Phe Lys Asp Asn Ala Ile Leu Ser 
    130                 135                 140                 


Asn Pro Val Ala Gly Leu Val Val Gly Ile Leu Val Thr Val Leu Val 
145                 150                 155                 160 


Gln Ser Ser Ser Thr Ser Thr Ser Ile Ile Val Ser Met Val Ser Ser 
                165                 170                 175     


Gly Leu Leu Glu Val Ser Ser Ala Ile Pro Ile Ile Met Gly Ser Asn 
            180                 185                 190         


Ile Gly Thr Ser Val Thr Asn Thr Ile Val Ala Leu Met Gln Ala Gly 
        195                 200                 205             


Asp Arg Thr Asp Phe Arg Arg Ala Phe Ala Gly Ala Thr Val His Asp 
    210                 215                 220                 


Cys Phe Asn Trp Leu Ser Val Leu Val Leu Leu Pro Leu Glu Ala Ala 
225                 230                 235                 240 


Thr Gly Tyr Leu His His Ile Thr Arg Leu Val Val Ala Ser Phe Asn 
                245                 250                 255     


Ile His Gly Gly Arg Asp Ala Pro Asp Leu Leu Lys Ile Ile Thr Glu 
            260                 265                 270         


Pro Phe Thr Lys Leu Ile Ile Gln Leu Asp Glu Ser Val Ile Thr Ser 
        275                 280                 285             


Ile Ala Thr Gly Asp Glu Ser Leu Arg Asn His Ser Leu Ile Gln Ile 
    290                 295                 300                 


Trp Cys His Pro Asp Ser Leu Gln Ala Pro Thr Ser Met Ser Arg Ala 
305                 310                 315                 320 


Glu Ala Asn Ser Ser Gln Thr Leu Gly Asn Ala Thr Met Glu Lys Cys 
                325                 330                 335     


Asn His Ile Phe Val Asp Thr Gly Leu Pro Asp Leu Ala Val Gly Leu 
            340                 345                 350         


Ile Leu Leu Ala Gly Ser Leu Val Leu Leu Cys Thr Cys Leu Ile Leu 
        355                 360                 365             


Leu Val Lys Met Leu Asn Ser Leu Leu Lys Gly Gln Val Ala Lys Val 
    370                 375                 380                 


Ile Gln Lys Val Ile Asn Thr Asp Phe Pro Ala Pro Phe Thr Trp Val 
385                 390                 395                 400 


Thr Gly Tyr Phe Ala Met Val Val Gly Ala Ser Met Thr Phe Val Val 
                405                 410                 415     


Gln Ser Ser Ser Val Phe Thr Ser Ala Ile Thr Pro Leu Ile Gly Leu 
            420                 425                 430         


Gly Val Ile Ser Ile Glu Arg Ala Tyr Pro Leu Thr Leu Gly Ser Asn 
        435                 440                 445             


Ile Gly Thr Thr Thr Thr Ala Ile Leu Ala Ala Leu Ala Ser Pro Arg 
    450                 455                 460                 


Glu Lys Leu Ser Ser Ala Phe Gln Ile Ala Leu Cys His Phe Phe Phe 
465                 470                 475                 480 


Asn Ile Ser Gly Ile Leu Leu Trp Tyr Pro Val Pro Cys Thr Arg Leu 
                485                 490                 495     


Pro Ile Arg Met Ala Lys Ala Leu Gly Lys Arg Thr Ala Lys Tyr Arg 
            500                 505                 510         


Trp Phe Ala Val Leu Tyr Leu Leu Val Cys Phe Leu Leu Leu Pro Ser 
        515                 520                 525             


Leu Val Phe Gly Ile Ser Met Ala Gly Trp Gln Val Met Val Gly Val 
    530                 535                 540                 


Gly Thr Pro Phe Gly Ala Leu Leu Ala Phe Val Val Leu Ile Asn Val 
545                 550                 555                 560 


Leu Gln Ser Arg Ser Pro Gly His Leu Pro Lys Trp Leu Gln Thr Trp 
                565                 570                 575     


Asp Phe Leu Pro Arg Trp Met His Ser Leu Lys Pro Leu Asp His Leu 
            580                 585                 590         


Ile Thr Arg Ala Thr Leu Cys Cys Ala Arg Pro Glu Pro Arg Ser Pro 
        595                 600                 605             


Pro Leu Pro Pro Arg Val Phe Leu Glu Glu Leu Pro Pro Ala Thr Pro 
    610                 615                 620                 


Ser Pro Arg Leu Ala Leu Pro Ala His His Asn Ala Thr Arg Leu 
625                 630                 635                 


<210>  2773
<211>  525
<212>  PRT
<213>  Homo sapiens

<400>  2773

Met Leu Arg Thr Ile Leu Asp Ala Pro Gln Arg Leu Leu Lys Glu Gly 
1               5                   10                  15      


Arg Ala Ser Arg Gln Leu Val Leu Val Val Val Phe Val Ala Leu Leu 
            20                  25                  30          


Leu Asp Asn Met Leu Phe Thr Val Val Val Pro Ile Val Pro Thr Phe 
        35                  40                  45              


Leu Tyr Asp Met Glu Phe Lys Glu Val Asn Ser Ser Leu His Leu Gly 
    50                  55                  60                  


His Ala Gly Ser Ser Pro His Ala Leu Ala Ser Pro Ala Phe Ser Thr 
65                  70                  75                  80  


Ile Phe Ser Phe Phe Asn Asn Asn Thr Val Ala Val Glu Glu Ser Val 
                85                  90                  95      


Pro Ser Gly Ile Ala Trp Met Asn Asp Thr Ala Ser Thr Ile Pro Pro 
            100                 105                 110         


Pro Ala Thr Glu Ala Ile Ser Ala His Lys Asn Asn Cys Leu Gln Gly 
        115                 120                 125             


Thr Gly Phe Leu Glu Glu Glu Ile Thr Arg Val Gly Val Leu Phe Ala 
    130                 135                 140                 


Ser Lys Ala Val Met Gln Leu Leu Val Asn Pro Phe Val Gly Pro Leu 
145                 150                 155                 160 


Thr Asn Arg Ile Gly Tyr His Ile Pro Met Phe Ala Gly Phe Val Ile 
                165                 170                 175     


Met Phe Leu Ser Thr Val Met Phe Ala Phe Ser Gly Thr Tyr Thr Leu 
            180                 185                 190         


Leu Phe Val Ala Arg Thr Leu Gln Gly Ile Gly Ser Ser Phe Ser Ser 
        195                 200                 205             


Val Ala Gly Leu Gly Met Leu Ala Ser Val Tyr Thr Asp Asp His Glu 
    210                 215                 220                 


Arg Gly Arg Ala Met Gly Thr Ala Leu Gly Gly Leu Ala Leu Gly Leu 
225                 230                 235                 240 


Leu Val Gly Ala Pro Phe Gly Ser Val Met Tyr Glu Phe Val Gly Lys 
                245                 250                 255     


Ser Ala Pro Phe Leu Ile Leu Ala Phe Leu Ala Leu Leu Asp Gly Ala 
            260                 265                 270         


Leu Gln Leu Cys Ile Leu Gln Pro Ser Lys Val Ser Pro Glu Ser Ala 
        275                 280                 285             


Lys Gly Thr Pro Leu Phe Met Leu Leu Lys Asp Pro Tyr Ile Leu Val 
    290                 295                 300                 


Ala Ala Gly Ser Ile Cys Phe Ala Asn Met Gly Val Ala Ile Leu Glu 
305                 310                 315                 320 


Pro Thr Leu Pro Ile Trp Met Met Gln Thr Met Cys Ser Pro Lys Trp 
                325                 330                 335     


Gln Leu Gly Leu Ala Phe Leu Pro Ala Ser Val Ser Tyr Leu Ile Gly 
            340                 345                 350         


Thr Asn Leu Phe Gly Val Leu Ala Asn Lys Met Gly Arg Trp Leu Cys 
        355                 360                 365             


Ser Leu Ile Gly Met Leu Val Val Gly Thr Ser Leu Leu Cys Val Pro 
    370                 375                 380                 


Leu Ala His Asn Ile Phe Gly Leu Ile Gly Pro Asn Ala Gly Leu Gly 
385                 390                 395                 400 


Leu Ala Ile Gly Met Val Asp Ser Ser Met Met Pro Ile Met Gly His 
                405                 410                 415     


Leu Val Asp Leu Arg His Thr Ser Val Tyr Gly Ser Val Tyr Ala Ile 
            420                 425                 430         


Ala Asp Val Ala Phe Cys Met Gly Phe Ala Ile Gly Pro Ser Thr Gly 
        435                 440                 445             


Gly Ala Ile Val Lys Ala Ile Gly Phe Pro Trp Leu Met Val Ile Thr 
    450                 455                 460                 


Gly Val Ile Asn Ile Val Tyr Ala Pro Leu Cys Tyr Tyr Leu Arg Ser 
465                 470                 475                 480 


Pro Pro Ala Lys Glu Glu Lys Leu Ala Ile Leu Ser Gln Asp Cys Pro 
                485                 490                 495     


Met Glu Thr Arg Met Tyr Ala Thr Gln Lys Pro Thr Lys Glu Phe Pro 
            500                 505                 510         


Leu Gly Glu Asp Ser Asp Glu Glu Pro Asp His Glu Glu 
        515                 520                 525 


<210>  2774
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  2774

Met Ala Leu Ser Glu Leu Ala Leu Val Arg Trp Leu Gln Glu Ser Arg 
1               5                   10                  15      


Arg Ser Arg Lys Leu Ile Leu Phe Ile Val Phe Leu Ala Leu Leu Leu 
            20                  25                  30          


Asp Asn Met Leu Leu Thr Val Val Val Pro Ile Ile Pro Ser Tyr Leu 
        35                  40                  45              


Tyr Ser Ile Lys His Glu Lys Asn Ala Thr Glu Ile Gln Thr Ala Arg 
    50                  55                  60                  


Pro Val His Thr Ala Ser Ile Ser Asp Ser Phe Gln Ser Ile Phe Ser 
65                  70                  75                  80  


Tyr Tyr Asp Asn Ser Thr Met Val Thr Gly Asn Ala Thr Arg Asp Leu 
                85                  90                  95      


Thr Leu His Gln Thr Ala Thr Gln His Met Val Thr Asn Ala Ser Ala 
            100                 105                 110         


Val Pro Ser Asp Cys Pro Ser Glu Asp Lys Asp Leu Leu Asn Glu Asn 
        115                 120                 125             


Val Gln Val Gly Leu Leu Phe Ala Ser Lys Ala Thr Val Gln Leu Ile 
    130                 135                 140                 


Thr Asn Pro Phe Ile Gly Leu Leu Thr Asn Arg Ile Gly Tyr Pro Ile 
145                 150                 155                 160 


Pro Ile Phe Ala Gly Phe Cys Ile Met Phe Val Ser Thr Ile Met Phe 
                165                 170                 175     


Ala Phe Ser Ser Ser Tyr Ala Phe Leu Leu Ile Ala Arg Ser Leu Gln 
            180                 185                 190         


Gly Ile Gly Ser Ser Cys Ser Ser Val Ala Gly Met Gly Met Leu Ala 
        195                 200                 205             


Ser Val Tyr Thr Asp Asp Glu Glu Arg Gly Asn Val Met Gly Ile Ala 
    210                 215                 220                 


Leu Gly Gly Leu Ala Met Gly Val Leu Val Gly Pro Pro Phe Gly Ser 
225                 230                 235                 240 


Val Leu Tyr Glu Phe Val Gly Lys Thr Ala Pro Phe Leu Val Leu Ala 
                245                 250                 255     


Ala Leu Val Leu Leu Asp Gly Ala Ile Gln Leu Phe Val Leu Gln Pro 
            260                 265                 270         


Ser Arg Val Gln Pro Glu Ser Gln Lys Gly Thr Pro Leu Thr Thr Leu 
        275                 280                 285             


Leu Lys Asp Pro Tyr Ile Leu Ile Ala Ala Gly Ser Ile Cys Phe Ala 
    290                 295                 300                 


Asn Met Gly Ile Ala Met Leu Glu Pro Ala Leu Pro Ile Trp Met Met 
305                 310                 315                 320 


Glu Thr Met Cys Ser Arg Lys Trp Gln Leu Gly Val Ala Phe Leu Pro 
                325                 330                 335     


Ala Ser Ile Ser Tyr Leu Ile Gly Thr Asn Ile Phe Gly Ile Leu Ala 
            340                 345                 350         


His Lys Met Gly Arg Trp Leu Cys Ala Leu Leu Gly Met Ile Ile Val 
        355                 360                 365             


Gly Val Ser Ile Leu Cys Ile Pro Phe Ala Lys Asn Ile Tyr Gly Leu 
    370                 375                 380                 


Ile Ala Pro Asn Phe Gly Val Gly Phe Ala Ile Gly Met Val Asp Ser 
385                 390                 395                 400 


Ser Met Met Pro Ile Met Gly Tyr Leu Val Asp Leu Arg His Val Ser 
                405                 410                 415     


Val Tyr Gly Ser Val Tyr Ala Ile Ala Asp Val Ala Phe Cys Met Gly 
            420                 425                 430         


Tyr Ala Ile Gly Pro Ser Ala Gly Gly Ala Ile Ala Lys Ala Ile Gly 
        435                 440                 445             


Phe Pro Trp Leu Met Thr Ile Ile Gly Ile Ile Asp Ile Leu Phe Ala 
    450                 455                 460                 


Pro Leu Cys Phe Phe Leu Arg Ser Pro Pro Ala Lys Glu Glu Lys Met 
465                 470                 475                 480 


Ala Ile Leu Met Asp His Asn Cys Pro Ile Lys Thr Lys Met Tyr Thr 
                485                 490                 495     


Gln Asn Asn Ile Gln Ser Tyr Pro Ile Gly Glu Asp Glu Glu Ser Glu 
            500                 505                 510         


Ser Asp 
        


<210>  2775
<211>  532
<212>  PRT
<213>  Homo sapiens

<400>  2775

Met Glu Ser Ala Glu Pro Ala Gly Gln Ala Arg Ala Ala Ala Thr Lys 
1               5                   10                  15      


Leu Ser Glu Ala Val Gly Ala Ala Leu Gln Glu Pro Arg Arg Gln Arg 
            20                  25                  30          


Arg Leu Val Leu Val Ile Val Cys Val Ala Leu Leu Leu Asp Asn Met 
        35                  40                  45              


Leu Tyr Met Val Ile Val Pro Ile Val Pro Asp Tyr Ile Ala His Met 
    50                  55                  60                  


Arg Gly Gly Gly Glu Gly Pro Thr Arg Thr Pro Glu Val Trp Glu Pro 
65                  70                  75                  80  


Thr Leu Pro Leu Pro Thr Pro Ala Asn Ala Ser Ala Tyr Thr Ala Asn 
                85                  90                  95      


Thr Ser Ala Ser Pro Thr Ala Ala Trp Pro Ala Gly Ser Ala Leu Arg 
            100                 105                 110         


Pro Arg Tyr Pro Thr Glu Ser Glu Asp Val Lys Ile Gly Val Leu Phe 
        115                 120                 125             


Ala Ser Lys Ala Ile Leu Gln Leu Leu Val Asn Pro Leu Ser Gly Pro 
    130                 135                 140                 


Phe Ile Asp Arg Met Ser Tyr Asp Val Pro Leu Leu Ile Gly Leu Gly 
145                 150                 155                 160 


Val Met Phe Ala Ser Thr Val Leu Phe Ala Phe Ala Glu Asp Tyr Ala 
                165                 170                 175     


Thr Leu Phe Ala Ala Arg Ser Leu Gln Gly Leu Gly Ser Ala Phe Ala 
            180                 185                 190         


Asp Thr Ser Gly Ile Ala Met Ile Ala Asp Lys Tyr Pro Glu Glu Pro 
        195                 200                 205             


Glu Arg Ser Arg Ala Leu Gly Val Ala Leu Ala Phe Ile Ser Phe Gly 
    210                 215                 220                 


Ser Leu Val Ala Pro Pro Phe Gly Gly Ile Leu Tyr Glu Phe Ala Gly 
225                 230                 235                 240 


Lys Arg Val Pro Phe Leu Val Leu Ala Ala Val Ser Leu Phe Asp Ala 
                245                 250                 255     


Leu Leu Leu Leu Ala Val Ala Lys Pro Phe Ser Ala Ala Ala Arg Ala 
            260                 265                 270         


Arg Ala Asn Leu Pro Val Gly Thr Pro Ile His Arg Leu Met Leu Asp 
        275                 280                 285             


Pro Tyr Ile Ala Val Val Ala Gly Ala Leu Thr Thr Cys Asn Ile Pro 
    290                 295                 300                 


Leu Ala Phe Leu Glu Pro Thr Ile Ala Thr Trp Met Lys His Thr Met 
305                 310                 315                 320 


Ala Ala Ser Glu Trp Glu Met Gly Met Ala Trp Leu Pro Ala Phe Val 
                325                 330                 335     


Pro His Val Leu Gly Val Tyr Leu Thr Val Arg Leu Ala Ala Arg Tyr 
            340                 345                 350         


Pro His Leu Gln Trp Leu Tyr Gly Ala Leu Gly Leu Ala Val Ile Gly 
        355                 360                 365             


Ala Ser Ser Cys Ile Val Pro Ala Cys Arg Ser Phe Ala Pro Leu Val 
    370                 375                 380                 


Val Ser Leu Cys Gly Leu Cys Phe Gly Ile Ala Leu Val Asp Thr Ala 
385                 390                 395                 400 


Leu Leu Pro Thr Leu Ala Phe Leu Val Asp Val Arg His Val Ser Val 
                405                 410                 415     


Tyr Gly Ser Val Tyr Ala Ile Ala Asp Ile Ser Tyr Ser Val Ala Tyr 
            420                 425                 430         


Ala Leu Gly Pro Ile Val Ala Gly His Ile Val His Ser Leu Gly Phe 
        435                 440                 445             


Glu Gln Leu Ser Leu Gly Met Gly Leu Ala Asn Leu Leu Tyr Ala Pro 
    450                 455                 460                 


Val Leu Leu Leu Leu Arg Asn Val Gly Leu Leu Thr Arg Ser Arg Ser 
465                 470                 475                 480 


Glu Arg Asp Val Leu Leu Asp Glu Pro Pro Gln Gly Leu Tyr Asp Ala 
                485                 490                 495     


Val Arg Leu Arg Glu Arg Pro Val Ser Gly Gln Asp Gly Glu Pro Arg 
            500                 505                 510         


Ser Pro Pro Gly Pro Phe Asp Ala Cys Glu Asp Asp Tyr Asn Tyr Tyr 
        515                 520                 525             


Tyr Thr Arg Ser 
    530         


<210>  2776
<211>  554
<212>  PRT
<213>  Homo sapiens

<400>  2776

Met Pro Thr Val Asp Asp Ile Leu Glu Gln Val Gly Glu Ser Gly Trp 
1               5                   10                  15      


Phe Gln Lys Gln Ala Phe Leu Ile Leu Cys Leu Leu Ser Ala Ala Phe 
            20                  25                  30          


Ala Pro Ile Cys Val Gly Ile Val Phe Leu Gly Phe Thr Pro Asp His 
        35                  40                  45              


His Cys Gln Ser Pro Gly Val Ala Glu Leu Ser Gln Arg Cys Gly Trp 
    50                  55                  60                  


Ser Pro Ala Glu Glu Leu Asn Tyr Thr Val Pro Gly Leu Gly Pro Ala 
65                  70                  75                  80  


Gly Glu Ala Phe Leu Gly Gln Cys Arg Arg Tyr Glu Val Asp Trp Asn 
                85                  90                  95      


Gln Ser Ala Leu Ser Cys Val Asp Pro Leu Ala Ser Leu Ala Thr Asn 
            100                 105                 110         


Arg Ser His Leu Pro Leu Gly Pro Cys Gln Asp Gly Trp Val Tyr Asp 
        115                 120                 125             


Thr Pro Gly Ser Ser Ile Val Thr Glu Phe Asn Leu Val Cys Ala Asp 
    130                 135                 140                 


Ser Trp Lys Leu Asp Leu Phe Gln Ser Cys Leu Asn Ala Gly Phe Leu 
145                 150                 155                 160 


Phe Gly Ser Leu Gly Val Gly Tyr Phe Ala Asp Arg Phe Gly Arg Lys 
                165                 170                 175     


Leu Cys Leu Leu Gly Thr Val Leu Val Asn Ala Val Ser Gly Val Leu 
            180                 185                 190         


Met Ala Phe Ser Pro Asn Tyr Met Ser Met Leu Leu Phe Arg Leu Leu 
        195                 200                 205             


Gln Gly Leu Val Ser Lys Gly Asn Trp Met Ala Gly Tyr Thr Leu Ile 
    210                 215                 220                 


Thr Glu Phe Val Gly Ser Gly Ser Arg Arg Thr Val Ala Ile Met Tyr 
225                 230                 235                 240 


Gln Met Ala Phe Thr Val Gly Leu Val Ala Leu Thr Gly Leu Ala Tyr 
                245                 250                 255     


Ala Leu Pro His Trp Arg Trp Leu Gln Leu Ala Val Ser Leu Pro Thr 
            260                 265                 270         


Phe Leu Phe Leu Leu Tyr Tyr Trp Cys Val Pro Glu Ser Pro Arg Trp 
        275                 280                 285             


Leu Leu Ser Gln Lys Arg Asn Thr Glu Ala Ile Lys Ile Met Asp His 
    290                 295                 300                 


Ile Ala Gln Lys Asn Gly Lys Leu Pro Pro Ala Asp Leu Lys Met Leu 
305                 310                 315                 320 


Ser Leu Glu Glu Asp Val Thr Glu Lys Leu Ser Pro Ser Phe Ala Asp 
                325                 330                 335     


Leu Phe Arg Thr Pro Arg Leu Arg Lys Arg Thr Phe Ile Leu Met Tyr 
            340                 345                 350         


Leu Trp Phe Thr Asp Ser Val Leu Tyr Gln Gly Leu Ile Leu His Met 
        355                 360                 365             


Gly Ala Thr Ser Gly Asn Leu Tyr Leu Asp Phe Leu Tyr Ser Ala Leu 
    370                 375                 380                 


Val Glu Ile Pro Gly Ala Phe Ile Ala Leu Ile Thr Ile Asp Arg Val 
385                 390                 395                 400 


Gly Arg Ile Tyr Pro Met Ala Met Ser Asn Leu Leu Ala Gly Ala Ala 
                405                 410                 415     


Cys Leu Val Met Ile Phe Ile Ser Pro Asp Leu His Trp Leu Asn Ile 
            420                 425                 430         


Ile Ile Met Cys Val Gly Arg Met Gly Ile Thr Ile Ala Ile Gln Met 
        435                 440                 445             


Ile Cys Leu Val Asn Ala Glu Leu Tyr Pro Thr Phe Val Arg Asn Leu 
    450                 455                 460                 


Gly Val Met Val Cys Ser Ser Leu Cys Asp Ile Gly Gly Ile Ile Thr 
465                 470                 475                 480 


Pro Phe Ile Val Phe Arg Leu Arg Glu Val Trp Gln Ala Leu Pro Leu 
                485                 490                 495     


Ile Leu Phe Ala Val Leu Gly Leu Leu Ala Ala Gly Val Thr Leu Leu 
            500                 505                 510         


Leu Pro Glu Thr Lys Gly Val Ala Leu Pro Glu Thr Met Lys Asp Ala 
        515                 520                 525             


Glu Asn Leu Gly Arg Lys Ala Lys Pro Lys Glu Asn Thr Ile Tyr Leu 
    530                 535                 540                 


Lys Val Gln Thr Ser Glu Pro Ser Gly Thr 
545                 550                 


<210>  2777
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  2777

Met Pro Thr Thr Val Asp Asp Val Leu Glu His Gly Gly Glu Phe His 
1               5                   10                  15      


Phe Phe Gln Lys Gln Met Phe Phe Leu Leu Ala Leu Leu Ser Ala Thr 
            20                  25                  30          


Phe Ala Pro Ile Tyr Val Gly Ile Val Phe Leu Gly Phe Thr Pro Asp 
        35                  40                  45              


His Arg Cys Arg Ser Pro Gly Val Ala Glu Leu Ser Leu Arg Cys Gly 
    50                  55                  60                  


Trp Ser Pro Ala Glu Glu Leu Asn Tyr Thr Val Pro Gly Pro Gly Pro 
65                  70                  75                  80  


Ala Gly Glu Ala Ser Pro Arg Gln Cys Arg Arg Tyr Glu Val Asp Trp 
                85                  90                  95      


Asn Gln Ser Thr Phe Asp Cys Val Asp Pro Leu Ala Ser Leu Asp Thr 
            100                 105                 110         


Asn Arg Ser Arg Leu Pro Leu Gly Pro Cys Arg Asp Gly Trp Val Tyr 
        115                 120                 125             


Glu Thr Pro Gly Ser Ser Ile Val Thr Glu Phe Asn Leu Val Cys Ala 
    130                 135                 140                 


Asn Ser Trp Met Leu Asp Leu Phe Gln Ser Ser Val Asn Val Gly Phe 
145                 150                 155                 160 


Phe Ile Gly Ser Met Ser Ile Gly Tyr Ile Ala Asp Arg Phe Gly Arg 
                165                 170                 175     


Lys Leu Cys Leu Leu Thr Thr Val Leu Ile Asn Ala Ala Ala Gly Val 
            180                 185                 190         


Leu Met Ala Ile Ser Pro Thr Tyr Thr Trp Met Leu Ile Phe Arg Leu 
        195                 200                 205             


Ile Gln Gly Leu Val Ser Lys Ala Gly Trp Leu Ile Gly Tyr Ile Leu 
    210                 215                 220                 


Ile Thr Glu Phe Val Gly Arg Arg Tyr Arg Arg Thr Val Gly Ile Phe 
225                 230                 235                 240 


Tyr Gln Val Ala Tyr Thr Val Gly Leu Leu Val Leu Ala Gly Val Ala 
                245                 250                 255     


Tyr Ala Leu Pro His Trp Arg Trp Leu Gln Phe Thr Val Ser Leu Pro 
            260                 265                 270         


Asn Phe Phe Phe Leu Leu Tyr Tyr Trp Cys Ile Pro Glu Ser Pro Arg 
        275                 280                 285             


Trp Leu Ile Ser Gln Asn Lys Asn Ala Glu Ala Met Arg Ile Ile Lys 
    290                 295                 300                 


His Ile Ala Lys Lys Asn Gly Lys Ser Leu Pro Ala Ser Leu Gln Arg 
305                 310                 315                 320 


Leu Arg Leu Glu Glu Glu Thr Gly Lys Lys Leu Asn Pro Ser Phe Leu 
                325                 330                 335     


Asp Leu Val Arg Thr Pro Gln Ile Arg Lys His Thr Met Ile Leu Met 
            340                 345                 350         


Tyr Asn Trp Phe Thr Ser Ser Val Leu Tyr Gln Gly Leu Ile Met His 
        355                 360                 365             


Met Gly Leu Ala Gly Asp Asn Ile Tyr Leu Asp Phe Phe Tyr Ser Ala 
    370                 375                 380                 


Leu Val Glu Phe Pro Ala Ala Phe Met Ile Ile Leu Thr Ile Asp Arg 
385                 390                 395                 400 


Ile Gly Arg Arg Tyr Pro Trp Ala Ala Ser Asn Met Val Ala Gly Ala 
                405                 410                 415     


Ala Cys Leu Ala Ser Val Phe Ile Pro Gly Asp Leu Gln Trp Leu Lys 
            420                 425                 430         


Ile Ile Ile Ser Cys Leu Gly Arg Met Gly Ile Thr Met Ala Tyr Glu 
        435                 440                 445             


Ile Val Cys Leu Val Asn Ala Glu Leu Tyr Pro Thr Phe Ile Arg Asn 
    450                 455                 460                 


Leu Gly Val His Ile Cys Ser Ser Met Cys Asp Ile Gly Gly Ile Ile 
465                 470                 475                 480 


Thr Pro Phe Leu Val Tyr Arg Leu Thr Asn Ile Trp Leu Glu Leu Pro 
                485                 490                 495     


Leu Met Val Phe Gly Val Leu Gly Leu Val Ala Gly Gly Leu Val Leu 
            500                 505                 510         


Leu Leu Pro Glu Thr Lys Gly Lys Ala Leu Pro Glu Thr Ile Glu Glu 
        515                 520                 525             


Ala Glu Asn Met Gln Arg Pro Arg Lys Asn Lys Glu Lys Met Ile Tyr 
    530                 535                 540                 


Leu Gln Val Gln Lys Leu Asp Ile Pro Leu Asn 
545                 550                 555 


<210>  2778
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  2778

Met Arg Asp Tyr Asp Glu Val Ile Ala Phe Leu Gly Glu Trp Gly Pro 
1               5                   10                  15      


Phe Gln Arg Leu Ile Phe Phe Leu Leu Ser Ala Ser Ile Ile Pro Asn 
            20                  25                  30          


Gly Phe Asn Gly Met Ser Val Val Phe Leu Ala Gly Thr Pro Glu His 
        35                  40                  45              


Arg Cys Arg Val Pro Asp Ala Ala Asn Leu Ser Ser Ala Trp Arg Asn 
    50                  55                  60                  


Asn Ser Val Pro Leu Arg Leu Arg Asp Gly Arg Glu Val Pro His Ser 
65                  70                  75                  80  


Cys Ser Arg Tyr Arg Leu Ala Thr Ile Ala Asn Phe Ser Ala Leu Gly 
                85                  90                  95      


Leu Glu Pro Gly Arg Asp Val Asp Leu Gly Gln Leu Glu Gln Glu Ser 
            100                 105                 110         


Cys Leu Asp Gly Trp Glu Phe Ser Gln Asp Val Tyr Leu Ser Thr Val 
        115                 120                 125             


Val Thr Glu Trp Asn Leu Val Cys Glu Asp Asn Trp Lys Val Pro Leu 
    130                 135                 140                 


Thr Thr Ser Leu Phe Phe Val Gly Val Leu Leu Gly Ser Phe Val Ser 
145                 150                 155                 160 


Gly Gln Leu Ser Asp Arg Phe Gly Arg Lys Asn Val Leu Phe Ala Thr 
                165                 170                 175     


Met Ala Val Gln Thr Gly Phe Ser Phe Leu Gln Ile Phe Ser Ile Ser 
            180                 185                 190         


Trp Glu Met Phe Thr Val Leu Phe Val Ile Val Gly Met Gly Gln Ile 
        195                 200                 205             


Ser Asn Tyr Val Val Ala Phe Ile Leu Gly Thr Glu Ile Leu Gly Lys 
    210                 215                 220                 


Ser Val Arg Ile Ile Phe Ser Thr Leu Gly Val Cys Thr Phe Phe Ala 
225                 230                 235                 240 


Val Gly Tyr Met Leu Leu Pro Leu Phe Ala Tyr Phe Ile Arg Asp Trp 
                245                 250                 255     


Arg Met Leu Leu Leu Ala Leu Thr Val Pro Gly Val Leu Cys Val Pro 
            260                 265                 270         


Leu Trp Trp Phe Ile Pro Glu Ser Pro Arg Trp Leu Ile Ser Gln Arg 
        275                 280                 285             


Arg Phe Arg Glu Ala Glu Asp Ile Ile Gln Lys Ala Ala Lys Met Asn 
    290                 295                 300                 


Asn Ile Ala Val Pro Ala Val Ile Phe Asp Ser Val Glu Glu Leu Asn 
305                 310                 315                 320 


Pro Leu Lys Gln Gln Lys Ala Phe Ile Leu Asp Leu Phe Arg Thr Arg 
                325                 330                 335     


Asn Ile Ala Ile Met Thr Ile Met Ser Leu Leu Leu Trp Met Leu Thr 
            340                 345                 350         


Ser Val Gly Tyr Phe Ala Leu Ser Leu Asp Ala Pro Asn Leu His Gly 
        355                 360                 365             


Asp Ala Tyr Leu Asn Cys Phe Leu Ser Ala Leu Ile Glu Ile Pro Ala 
    370                 375                 380                 


Tyr Ile Thr Ala Trp Leu Leu Leu Arg Thr Leu Pro Arg Arg Tyr Ile 
385                 390                 395                 400 


Ile Ala Ala Val Leu Phe Trp Gly Gly Gly Val Leu Leu Phe Ile Gln 
                405                 410                 415     


Leu Val Pro Val Asp Tyr Tyr Phe Leu Ser Ile Gly Leu Val Met Leu 
            420                 425                 430         


Gly Lys Phe Gly Ile Thr Ser Ala Phe Ser Met Leu Tyr Val Phe Thr 
        435                 440                 445             


Ala Glu Leu Tyr Pro Thr Leu Val Arg Asn Met Ala Val Gly Val Thr 
    450                 455                 460                 


Ser Thr Ala Ser Arg Val Gly Ser Ile Ile Ala Pro Tyr Phe Val Tyr 
465                 470                 475                 480 


Leu Gly Ala Tyr Asn Arg Met Leu Pro Tyr Ile Val Met Gly Ser Leu 
                485                 490                 495     


Thr Val Leu Ile Gly Ile Leu Thr Leu Phe Phe Pro Glu Ser Leu Gly 
            500                 505                 510         


Met Thr Leu Pro Glu Thr Leu Glu Gln Met Gln Lys Val Lys Trp Phe 
        515                 520                 525             


Arg Ser Gly Lys Lys Thr Arg Asp Ser Met Glu Thr Glu Glu Asn Pro 
    530                 535                 540                 


Lys Val Leu Ile Thr Ala Phe 
545                 550     


<210>  2779
<211>  557
<212>  PRT
<213>  Homo sapiens

<400>  2779

Met Arg Asp Tyr Asp Glu Val Thr Ala Phe Leu Gly Glu Trp Gly Pro 
1               5                   10                  15      


Phe Gln Arg Leu Ile Phe Phe Leu Leu Ser Ala Ser Ile Ile Pro Asn 
            20                  25                  30          


Gly Phe Thr Gly Leu Ser Ser Val Phe Leu Ile Ala Thr Pro Glu His 
        35                  40                  45              


Arg Cys Arg Val Pro Asp Ala Ala Asn Leu Ser Ser Ala Trp Arg Asn 
    50                  55                  60                  


His Thr Val Pro Leu Arg Leu Arg Asp Gly Arg Glu Val Pro His Ser 
65                  70                  75                  80  


Cys Arg Arg Tyr Arg Leu Ala Thr Ile Ala Asn Phe Ser Ala Leu Gly 
                85                  90                  95      


Leu Glu Pro Gly Arg Asp Val Asp Leu Gly Gln Leu Glu Gln Glu Ser 
            100                 105                 110         


Cys Leu Asp Gly Trp Glu Phe Ser Gln Asp Val Tyr Leu Ser Thr Ile 
        115                 120                 125             


Val Thr Glu Trp Asn Leu Val Cys Glu Asp Asp Trp Lys Ala Pro Leu 
    130                 135                 140                 


Thr Ile Ser Leu Phe Phe Val Gly Val Leu Leu Gly Ser Phe Ile Ser 
145                 150                 155                 160 


Gly Gln Leu Ser Asp Arg Phe Gly Arg Lys Asn Val Leu Phe Val Thr 
                165                 170                 175     


Met Gly Met Gln Thr Gly Phe Ser Phe Leu Gln Ile Phe Ser Lys Asn 
            180                 185                 190         


Phe Glu Met Phe Val Val Leu Phe Val Leu Val Gly Met Gly Gln Ile 
        195                 200                 205             


Ser Asn Tyr Val Ala Ala Phe Val Leu Gly Thr Glu Ile Leu Gly Lys 
    210                 215                 220                 


Ser Val Arg Ile Ile Phe Ser Thr Leu Gly Val Cys Ile Phe Tyr Ala 
225                 230                 235                 240 


Phe Gly Tyr Met Val Leu Pro Leu Phe Ala Tyr Phe Ile Arg Asp Trp 
                245                 250                 255     


Arg Met Leu Leu Val Ala Leu Thr Met Pro Gly Val Leu Cys Val Ala 
            260                 265                 270         


Leu Trp Trp Phe Ile Pro Glu Ser Pro Arg Trp Leu Ile Ser Gln Gly 
        275                 280                 285             


Arg Phe Glu Glu Ala Glu Val Ile Ile Arg Lys Ala Ala Lys Ala Asn 
    290                 295                 300                 


Gly Ile Val Val Pro Ser Thr Ile Phe Asp Pro Ser Glu Leu Gln Asp 
305                 310                 315                 320 


Leu Ser Ser Lys Lys Gln Gln Ser His Asn Ile Leu Asp Leu Leu Arg 
                325                 330                 335     


Thr Trp Asn Ile Arg Met Val Thr Ile Met Ser Ile Met Leu Trp Met 
            340                 345                 350         


Thr Ile Ser Val Gly Tyr Phe Gly Leu Ser Leu Asp Thr Pro Asn Leu 
        355                 360                 365             


His Gly Asp Ile Phe Val Asn Cys Phe Leu Ser Ala Met Val Glu Val 
    370                 375                 380                 


Pro Ala Tyr Val Leu Ala Trp Leu Leu Leu Gln Tyr Leu Pro Arg Arg 
385                 390                 395                 400 


Tyr Ser Met Ala Thr Ala Leu Phe Leu Gly Gly Ser Val Leu Leu Phe 
                405                 410                 415     


Met Gln Leu Val Pro Pro Asp Leu Tyr Tyr Leu Ala Thr Val Leu Val 
            420                 425                 430         


Met Val Gly Lys Phe Gly Val Thr Ala Ala Phe Ser Met Val Tyr Val 
        435                 440                 445             


Tyr Thr Ala Glu Leu Tyr Pro Thr Val Val Arg Asn Met Gly Val Gly 
    450                 455                 460                 


Val Ser Ser Thr Ala Ser Arg Leu Gly Ser Ile Leu Ser Pro Tyr Phe 
465                 470                 475                 480 


Val Tyr Leu Gly Ala Tyr Asp Arg Phe Leu Pro Tyr Ile Leu Met Gly 
                485                 490                 495     


Ser Leu Thr Ile Leu Thr Ala Ile Leu Thr Leu Phe Leu Pro Glu Ser 
            500                 505                 510         


Phe Gly Thr Pro Leu Pro Asp Thr Ile Asp Gln Met Leu Arg Val Lys 
        515                 520                 525             


Gly Met Lys His Arg Lys Thr Pro Ser His Thr Arg Met Leu Lys Asp 
    530                 535                 540                 


Gly Gln Glu Arg Pro Thr Ile Leu Lys Ser Thr Ala Phe 
545                 550                 555         


<210>  2780
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  2780

Met Gly Ile Asn Thr Arg Glu Leu Phe Leu Asn Phe Thr Ile Val Leu 
1               5                   10                  15      


Ile Thr Val Ile Leu Met Trp Leu Leu Val Arg Ser Tyr Gln Tyr 
            20                  25                  30      


<210>  2781
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  2781

Met Lys Pro Asn Phe Ser Leu Arg Leu Arg Ile Phe Asn Leu Asn Cys 
1               5                   10                  15      


Trp Gly Ile Pro Tyr Leu Ser Lys His Arg Ala Asp Arg Met Arg Arg 
            20                  25                  30          


Leu Gly Asp Phe Leu Asn Gln Glu Ser Phe Asp Leu Ala Leu Leu Glu 
        35                  40                  45              


Glu Val Trp Ser Glu Gln Asp Phe Gln Tyr Leu Arg Gln Lys Leu Ser 
    50                  55                  60                  


Pro Thr Tyr Pro Ala Ala His His Phe Arg Ser Gly Ile Ile Gly Ser 
65                  70                  75                  80  


Gly Leu Cys Val Phe Ser Lys His Pro Ile Gln Glu Leu Thr Gln His 
                85                  90                  95      


Ile Tyr Thr Leu Asn Gly Tyr Pro Tyr Met Ile His His Gly Asp Trp 
            100                 105                 110         


Phe Ser Gly Lys Ala Val Gly Leu Leu Val Leu His Leu Ser Gly Met 
        115                 120                 125             


Val Leu Asn Ala Tyr Val Thr His Leu His Ala Glu Tyr Asn Arg Gln 
    130                 135                 140                 


Lys Asp Ile Tyr Leu Ala His Arg Val Ala Gln Ala Trp Glu Leu Ala 
145                 150                 155                 160 


Gln Phe Ile His His Thr Ser Lys Lys Ala Asp Val Val Leu Leu Cys 
                165                 170                 175     


Gly Asp Leu Asn Met His Pro Glu Asp Leu Gly Cys Cys Leu Leu Lys 
            180                 185                 190         


Glu Trp Thr Gly Leu His Asp Ala Tyr Leu Glu Thr Arg Asp Phe Lys 
        195                 200                 205             


Gly Ser Glu Glu Gly Asn Thr Met Val Pro Lys Asn Cys Tyr Val Ser 
    210                 215                 220                 


Gln Gln Glu Leu Lys Pro Phe Pro Phe Gly Val Arg Ile Asp Tyr Val 
225                 230                 235                 240 


Leu Tyr Lys Ala Val Ser Gly Phe Tyr Ile Ser Cys Lys Ser Phe Glu 
                245                 250                 255     


Thr Thr Thr Gly Phe Asp Pro His Arg Gly Thr Pro Leu Ser Asp His 
            260                 265                 270         


Glu Ala Leu Met Ala Thr Leu Phe Val Arg His Ser Pro Pro Gln Gln 
        275                 280                 285             


Asn Pro Ser Ser Thr His Gly Pro Ala Glu Arg Ser Pro Leu Met Cys 
    290                 295                 300                 


Val Leu Lys Glu Ala Trp Thr Glu Leu Gly Leu Gly Met Ala Gln Ala 
305                 310                 315                 320 


Arg Trp Trp Ala Thr Phe Ala Ser Tyr Val Ile Gly Leu Gly Leu Leu 
                325                 330                 335     


Leu Leu Ala Leu Leu Cys Val Leu Ala Ala Gly Gly Gly Ala Gly Glu 
            340                 345                 350         


Ala Ala Ile Leu Leu Trp Thr Pro Ser Val Gly Leu Val Leu Trp Ala 
        355                 360                 365             


Gly Ala Phe Tyr Leu Phe His Val Gln Glu Val Asn Gly Leu Tyr Arg 
    370                 375                 380                 


Ala Gln Ala Glu Leu Gln His Val Leu Gly Arg Ala Arg Glu Ala Gln 
385                 390                 395                 400 


Asp Leu Gly Pro Glu Pro Gln Pro Ala Leu Leu Leu Gly Gln Gln Glu 
                405                 410                 415     


Gly Asp Arg Thr Lys Glu Gln 
            420             


<210>  2782
<211>  550
<212>  PRT
<213>  Homo sapiens

<400>  2782

Met Val Gly Glu Glu Lys Met Ser Leu Arg Asn Arg Leu Ser Lys Ser 
1               5                   10                  15      


Arg Glu Asn Pro Glu Glu Asp Glu Asp Gln Arg Asn Pro Ala Lys Glu 
            20                  25                  30          


Ser Leu Glu Thr Pro Ser Asn Gly Arg Ile Asp Ile Lys Gln Leu Ile 
        35                  40                  45              


Ala Lys Lys Ile Lys Leu Thr Ala Glu Ala Glu Glu Leu Lys Pro Phe 
    50                  55                  60                  


Phe Met Lys Glu Val Gly Ser His Phe Asp Asp Phe Val Thr Asn Leu 
65                  70                  75                  80  


Ile Glu Lys Ser Ala Ser Leu Asp Asn Gly Gly Cys Ala Leu Thr Thr 
                85                  90                  95      


Phe Ser Val Leu Glu Gly Glu Lys Asn Asn His Arg Ala Lys Asp Leu 
            100                 105                 110         


Arg Ala Pro Pro Glu Gln Gly Lys Ile Phe Ile Ala Arg Arg Ser Leu 
        115                 120                 125             


Leu Asp Glu Leu Leu Glu Val Asp His Ile Arg Thr Ile Tyr His Met 
    130                 135                 140                 


Phe Ile Ala Leu Leu Ile Leu Phe Ile Leu Ser Thr Leu Val Val Asp 
145                 150                 155                 160 


Tyr Ile Asp Glu Gly Arg Leu Val Leu Glu Phe Ser Leu Leu Ser Tyr 
                165                 170                 175     


Ala Phe Gly Lys Phe Pro Thr Val Val Trp Thr Trp Trp Ile Met Phe 
            180                 185                 190         


Leu Ser Thr Phe Ser Val Pro Tyr Phe Leu Phe Gln His Trp Ala Thr 
        195                 200                 205             


Gly Tyr Ser Lys Ser Ser His Pro Leu Ile Arg Ser Leu Phe His Gly 
    210                 215                 220                 


Phe Leu Phe Met Ile Phe Gln Ile Gly Val Leu Gly Phe Gly Pro Thr 
225                 230                 235                 240 


Tyr Val Val Leu Ala Tyr Thr Leu Pro Pro Ala Ser Arg Phe Ile Ile 
                245                 250                 255     


Ile Phe Glu Gln Ile Arg Phe Val Met Lys Ala His Ser Phe Val Arg 
            260                 265                 270         


Glu Asn Val Pro Arg Val Leu Asn Ser Ala Lys Glu Lys Ser Ser Thr 
        275                 280                 285             


Val Pro Ile Pro Thr Val Asn Gln Tyr Leu Tyr Phe Leu Phe Ala Pro 
    290                 295                 300                 


Thr Leu Ile Tyr Arg Asp Ser Tyr Pro Arg Asn Pro Thr Val Arg Trp 
305                 310                 315                 320 


Gly Tyr Val Ala Met Lys Phe Ala Gln Val Phe Gly Cys Phe Phe Tyr 
                325                 330                 335     


Val Tyr Tyr Ile Phe Glu Arg Leu Cys Ala Pro Leu Phe Arg Asn Ile 
            340                 345                 350         


Lys Gln Glu Pro Phe Ser Ala Arg Val Leu Val Leu Cys Val Phe Asn 
        355                 360                 365             


Ser Ile Leu Pro Gly Val Leu Ile Leu Phe Leu Thr Phe Phe Ala Phe 
    370                 375                 380                 


Leu His Cys Trp Leu Asn Ala Phe Ala Glu Met Leu Arg Phe Gly Asp 
385                 390                 395                 400 


Arg Met Phe Tyr Lys Asp Trp Trp Asn Ser Thr Ser Tyr Ser Asn Tyr 
                405                 410                 415     


Tyr Arg Thr Trp Asn Val Val Val His Asp Trp Leu Tyr Tyr Tyr Ala 
            420                 425                 430         


Tyr Lys Asp Phe Leu Trp Phe Phe Ser Lys Arg Phe Lys Ser Ala Ala 
        435                 440                 445             


Met Leu Ala Val Phe Ala Val Ser Ala Val Val His Glu Tyr Ala Leu 
    450                 455                 460                 


Ala Val Cys Leu Ser Phe Phe Tyr Pro Val Leu Phe Val Leu Phe Met 
465                 470                 475                 480 


Phe Phe Gly Met Ala Phe Asn Phe Ile Val Asn Asp Ser Arg Lys Lys 
                485                 490                 495     


Pro Ile Trp Asn Val Leu Met Trp Thr Ser Leu Phe Leu Gly Asn Gly 
            500                 505                 510         


Val Leu Leu Cys Phe Tyr Ser Gln Glu Trp Tyr Ala Arg Gln His Cys 
        515                 520                 525             


Pro Leu Lys Asn Pro Thr Phe Leu Asp Tyr Val Arg Pro Arg Ser Trp 
    530                 535                 540                 


Thr Cys Arg Tyr Val Phe 
545                 550 


<210>  2783
<211>  2214
<212>  PRT
<213>  Homo sapiens

<400>  2783

Met Ala Thr Arg Ser Ser Arg Arg Glu Ser Arg Leu Pro Phe Leu Phe 
1               5                   10                  15      


Thr Leu Val Ala Leu Leu Pro Pro Gly Ala Leu Cys Glu Val Trp Thr 
            20                  25                  30          


Gln Arg Leu His Gly Gly Ser Ala Pro Leu Pro Gln Asp Arg Gly Phe 
        35                  40                  45              


Leu Val Val Gln Gly Asp Pro Arg Glu Leu Arg Leu Trp Ala Arg Gly 
    50                  55                  60                  


Asp Ala Arg Gly Ala Ser Arg Ala Asp Glu Lys Pro Leu Arg Arg Lys 
65                  70                  75                  80  


Arg Ser Ala Ala Leu Gln Pro Glu Pro Ile Lys Val Tyr Gly Gln Val 
                85                  90                  95      


Ser Leu Asn Asp Ser His Asn Gln Met Val Val His Trp Ala Gly Glu 
            100                 105                 110         


Lys Ser Asn Val Ile Val Ala Leu Ala Arg Asp Ser Leu Ala Leu Ala 
        115                 120                 125             


Arg Pro Lys Ser Ser Asp Val Tyr Val Ser Tyr Asp Tyr Gly Lys Ser 
    130                 135                 140                 


Phe Lys Lys Ile Ser Asp Lys Leu Asn Phe Gly Leu Gly Asn Arg Ser 
145                 150                 155                 160 


Glu Ala Val Ile Ala Gln Phe Tyr His Ser Pro Ala Asp Asn Lys Arg 
                165                 170                 175     


Tyr Ile Phe Ala Asp Ala Tyr Ala Gln Tyr Leu Trp Ile Thr Phe Asp 
            180                 185                 190         


Phe Cys Asn Thr Leu Gln Gly Phe Ser Ile Pro Phe Arg Ala Ala Asp 
        195                 200                 205             


Leu Leu Leu His Ser Lys Ala Ser Asn Leu Leu Leu Gly Phe Asp Arg 
    210                 215                 220                 


Ser His Pro Asn Lys Gln Leu Trp Lys Ser Asp Asp Phe Gly Gln Thr 
225                 230                 235                 240 


Trp Ile Met Ile Gln Glu His Val Lys Ser Phe Ser Trp Gly Ile Asp 
                245                 250                 255     


Pro Tyr Asp Lys Pro Asn Thr Ile Tyr Ile Glu Arg His Glu Pro Ser 
            260                 265                 270         


Gly Tyr Ser Thr Val Phe Arg Ser Thr Asp Phe Phe Gln Ser Arg Glu 
        275                 280                 285             


Asn Gln Glu Val Ile Leu Glu Glu Val Arg Asp Phe Gln Leu Arg Asp 
    290                 295                 300                 


Lys Tyr Met Phe Ala Thr Lys Val Val His Leu Leu Gly Ser Glu Gln 
305                 310                 315                 320 


Gln Ser Ser Val Gln Leu Trp Val Ser Phe Gly Arg Lys Pro Met Arg 
                325                 330                 335     


Ala Ala Gln Phe Val Thr Arg His Pro Ile Asn Glu Tyr Tyr Ile Ala 
            340                 345                 350         


Asp Ala Ser Glu Asp Gln Val Phe Val Cys Val Ser His Ser Asn Asn 
        355                 360                 365             


Arg Thr Asn Leu Tyr Ile Ser Glu Ala Glu Gly Leu Lys Phe Ser Leu 
    370                 375                 380                 


Ser Leu Glu Asn Val Leu Tyr Tyr Ser Pro Gly Gly Ala Gly Ser Asp 
385                 390                 395                 400 


Thr Leu Val Arg Tyr Phe Ala Asn Glu Pro Phe Ala Asp Phe His Arg 
                405                 410                 415     


Val Glu Gly Leu Gln Gly Val Tyr Ile Ala Thr Leu Ile Asn Gly Ser 
            420                 425                 430         


Met Asn Glu Glu Asn Met Arg Ser Val Ile Thr Phe Asp Lys Gly Gly 
        435                 440                 445             


Thr Trp Glu Phe Leu Gln Ala Pro Ala Phe Thr Gly Tyr Gly Glu Lys 
    450                 455                 460                 


Ile Asn Cys Glu Leu Ser Gln Gly Cys Ser Leu His Leu Ala Gln Arg 
465                 470                 475                 480 


Leu Ser Gln Leu Leu Asn Leu Gln Leu Arg Arg Met Pro Ile Leu Ser 
                485                 490                 495     


Lys Glu Ser Ala Pro Gly Leu Ile Ile Ala Thr Gly Ser Val Gly Lys 
            500                 505                 510         


Asn Leu Ala Ser Lys Thr Asn Val Tyr Ile Ser Ser Ser Ala Gly Ala 
        515                 520                 525             


Arg Trp Arg Glu Ala Leu Pro Gly Pro His Tyr Tyr Thr Trp Gly Asp 
    530                 535                 540                 


His Gly Gly Ile Ile Thr Ala Ile Ala Gln Gly Met Glu Thr Asn Glu 
545                 550                 555                 560 


Leu Lys Tyr Ser Thr Asn Glu Gly Glu Thr Trp Lys Thr Phe Ile Phe 
                565                 570                 575     


Ser Glu Lys Pro Val Phe Val Tyr Gly Leu Leu Thr Glu Pro Gly Glu 
            580                 585                 590         


Lys Ser Thr Val Phe Thr Ile Phe Gly Ser Asn Lys Glu Asn Val His 
        595                 600                 605             


Ser Trp Leu Ile Leu Gln Val Asn Ala Thr Asp Ala Leu Gly Val Pro 
    610                 615                 620                 


Cys Thr Glu Asn Asp Tyr Lys Leu Trp Ser Pro Ser Asp Glu Arg Gly 
625                 630                 635                 640 


Asn Glu Cys Leu Leu Gly His Lys Thr Val Phe Lys Arg Arg Thr Pro 
                645                 650                 655     


His Ala Thr Cys Phe Asn Gly Glu Asp Phe Asp Arg Pro Val Val Val 
            660                 665                 670         


Ser Asn Cys Ser Cys Thr Arg Glu Asp Tyr Glu Cys Asp Phe Gly Phe 
        675                 680                 685             


Lys Met Ser Glu Asp Leu Ser Leu Glu Val Cys Val Pro Asp Pro Glu 
    690                 695                 700                 


Phe Ser Gly Lys Ser Tyr Ser Pro Pro Val Pro Cys Pro Val Gly Ser 
705                 710                 715                 720 


Thr Tyr Arg Arg Thr Arg Gly Tyr Arg Lys Ile Ser Gly Asp Thr Cys 
                725                 730                 735     


Ser Gly Gly Asp Val Glu Ala Arg Leu Glu Gly Glu Leu Val Pro Cys 
            740                 745                 750         


Pro Leu Ala Glu Glu Asn Glu Phe Ile Leu Tyr Ala Val Arg Lys Ser 
        755                 760                 765             


Ile Tyr Arg Tyr Asp Leu Ala Ser Gly Ala Thr Glu Gln Leu Pro Leu 
    770                 775                 780                 


Thr Gly Leu Arg Ala Ala Val Ala Leu Asp Phe Asp Tyr Glu His Asn 
785                 790                 795                 800 


Cys Leu Tyr Trp Ser Asp Leu Ala Leu Asp Val Ile Gln Arg Leu Cys 
                805                 810                 815     


Leu Asn Gly Ser Thr Gly Gln Glu Val Ile Ile Asn Ser Gly Leu Glu 
            820                 825                 830         


Thr Val Glu Ala Leu Ala Phe Glu Pro Leu Ser Gln Leu Leu Tyr Trp 
        835                 840                 845             


Val Asp Ala Gly Phe Lys Lys Ile Glu Val Ala Asn Pro Asp Gly Asp 
    850                 855                 860                 


Phe Arg Leu Thr Ile Val Asn Ser Ser Val Leu Asp Arg Pro Arg Ala 
865                 870                 875                 880 


Leu Val Leu Val Pro Gln Glu Gly Val Met Phe Trp Thr Asp Trp Gly 
                885                 890                 895     


Asp Leu Lys Pro Gly Ile Tyr Arg Ser Asn Met Asp Gly Ser Ala Ala 
            900                 905                 910         


Tyr His Leu Val Ser Glu Asp Val Lys Trp Pro Asn Gly Ile Ser Val 
        915                 920                 925             


Asp Asp Gln Trp Ile Tyr Trp Thr Asp Ala Tyr Leu Glu Cys Ile Glu 
    930                 935                 940                 


Arg Ile Thr Phe Ser Gly Gln Gln Arg Ser Val Ile Leu Asp Asn Leu 
945                 950                 955                 960 


Pro His Pro Tyr Ala Ile Ala Val Phe Lys Asn Glu Ile Tyr Trp Asp 
                965                 970                 975     


Asp Trp Ser Gln Leu Ser Ile Phe Arg Ala Ser Lys Tyr Ser Gly Ser 
            980                 985                 990         


Gln Met Glu Ile Leu Ala Asn Gln  Leu Thr Gly Leu Met  Asp Met Lys 
        995                 1000                 1005             


Ile Phe  Tyr Lys Gly Lys Asn  Thr Gly Ser Asn Ala  Cys Val Pro 
    1010                 1015                 1020             


Arg Pro  Cys Ser Leu Leu Cys  Leu Pro Lys Ala Asn  Asn Ser Arg 
    1025                 1030                 1035             


Ser Cys  Arg Cys Pro Glu Asp  Val Ser Ser Ser Val  Leu Pro Ser 
    1040                 1045                 1050             


Gly Asp  Leu Met Cys Asp Cys  Pro Gln Gly Tyr Gln  Leu Lys Asn 
    1055                 1060                 1065             


Asn Thr  Cys Val Lys Glu Glu  Asn Thr Cys Leu Arg  Asn Gln Tyr 
    1070                 1075                 1080             


Arg Cys  Ser Asn Gly Asn Cys  Ile Asn Ser Ile Trp  Trp Cys Asp 
    1085                 1090                 1095             


Phe Asp  Asn Asp Cys Gly Asp  Met Ser Asp Glu Arg  Asn Cys Pro 
    1100                 1105                 1110             


Thr Thr  Ile Cys Asp Leu Asp  Thr Gln Phe Arg Cys  Gln Glu Ser 
    1115                 1120                 1125             


Gly Thr  Cys Ile Pro Leu Ser  Tyr Lys Cys Asp Leu  Glu Asp Asp 
    1130                 1135                 1140             


Cys Gly  Asp Asn Ser Asp Glu  Ser His Cys Glu Met  His Gln Cys 
    1145                 1150                 1155             


Arg Ser  Asp Glu Tyr Asn Cys  Ser Ser Gly Met Cys  Ile Arg Ser 
    1160                 1165                 1170             


Ser Trp  Val Cys Asp Gly Asp  Asn Asp Cys Arg Asp  Trp Ser Asp 
    1175                 1180                 1185             


Glu Ala  Asn Cys Thr Ala Ile  Tyr His Thr Cys Glu  Ala Ser Asn 
    1190                 1195                 1200             


Phe Gln  Cys Arg Asn Gly His  Cys Ile Pro Gln Arg  Trp Ala Cys 
    1205                 1210                 1215             


Asp Gly  Asp Thr Asp Cys Gln  Asp Gly Ser Asp Glu  Asp Pro Val 
    1220                 1225                 1230             


Asn Cys  Glu Lys Lys Cys Asn  Gly Phe Arg Cys Pro  Asn Gly Thr 
    1235                 1240                 1245             


Cys Ile  Pro Ser Ser Lys His  Cys Asp Gly Leu Arg  Asp Cys Ser 
    1250                 1255                 1260             


Asp Gly  Ser Asp Glu Gln His  Cys Glu Pro Leu Cys  Thr His Phe 
    1265                 1270                 1275             


Met Asp  Phe Val Cys Lys Asn  Arg Gln Gln Cys Leu  Phe His Ser 
    1280                 1285                 1290             


Met Val  Cys Asp Gly Ile Ile  Gln Cys Arg Asp Gly  Ser Asp Glu 
    1295                 1300                 1305             


Asp Ala  Ala Phe Ala Gly Cys  Ser Gln Asp Pro Glu  Phe His Lys 
    1310                 1315                 1320             


Val Cys  Asp Glu Phe Gly Phe  Gln Cys Gln Asn Gly  Val Cys Ile 
    1325                 1330                 1335             


Ser Leu  Ile Trp Lys Cys Asp  Gly Met Asp Asp Cys  Gly Asp Tyr 
    1340                 1345                 1350             


Ser Asp  Glu Ala Asn Cys Glu  Asn Pro Thr Glu Ala  Pro Asn Cys 
    1355                 1360                 1365             


Ser Arg  Tyr Phe Gln Phe Arg  Cys Glu Asn Gly His  Cys Ile Pro 
    1370                 1375                 1380             


Asn Arg  Trp Lys Cys Asp Arg  Glu Asn Asp Cys Gly  Asp Trp Ser 
    1385                 1390                 1395             


Asp Glu  Lys Asp Cys Gly Asp  Ser His Ile Leu Pro  Phe Ser Thr 
    1400                 1405                 1410             


Pro Gly  Pro Ser Thr Cys Leu  Pro Asn Tyr Tyr Arg  Cys Ser Ser 
    1415                 1420                 1425             


Gly Thr  Cys Val Met Asp Thr  Trp Val Cys Asp Gly  Tyr Arg Asp 
    1430                 1435                 1440             


Cys Ala  Asp Gly Ser Asp Glu  Glu Ala Cys Pro Leu  Leu Ala Asn 
    1445                 1450                 1455             


Val Thr  Ala Ala Ser Thr Pro  Thr Gln Leu Gly Arg  Cys Asp Arg 
    1460                 1465                 1470             


Phe Glu  Phe Glu Cys His Gln  Pro Lys Thr Cys Ile  Pro Asn Trp 
    1475                 1480                 1485             


Lys Arg  Cys Asp Gly His Gln  Asp Cys Gln Asp Gly  Arg Asp Glu 
    1490                 1495                 1500             


Ala Asn  Cys Pro Thr His Ser  Thr Leu Thr Cys Met  Ser Arg Glu 
    1505                 1510                 1515             


Phe Gln  Cys Glu Asp Gly Glu  Ala Cys Ile Val Leu  Ser Glu Arg 
    1520                 1525                 1530             


Cys Asp  Gly Phe Leu Asp Cys  Ser Asp Glu Ser Asp  Glu Lys Ala 
    1535                 1540                 1545             


Cys Ser  Asp Glu Leu Thr Val  Tyr Lys Val Gln Asn  Leu Gln Trp 
    1550                 1555                 1560             


Thr Ala  Asp Phe Ser Gly Asp  Val Thr Leu Thr Trp  Met Arg Pro 
    1565                 1570                 1575             


Lys Lys  Met Pro Ser Ala Ser  Cys Val Tyr Asn Val  Tyr Tyr Arg 
    1580                 1585                 1590             


Val Val  Gly Glu Ser Ile Trp  Lys Thr Leu Glu Thr  His Ser Asn 
    1595                 1600                 1605             


Lys Thr  Asn Thr Val Leu Lys  Val Leu Lys Pro Asp  Thr Thr Tyr 
    1610                 1615                 1620             


Gln Val  Lys Val Gln Val Gln  Cys Leu Ser Lys Ala  His Asn Thr 
    1625                 1630                 1635             


Asn Asp  Phe Val Thr Leu Arg  Thr Pro Glu Gly Leu  Pro Asp Ala 
    1640                 1645                 1650             


Pro Arg  Asn Leu Gln Leu Ser  Leu Pro Arg Glu Ala  Glu Gly Val 
    1655                 1660                 1665             


Ile Val  Gly His Trp Ala Pro  Pro Ile His Thr His  Gly Leu Ile 
    1670                 1675                 1680             


Arg Glu  Tyr Ile Val Glu Tyr  Ser Arg Ser Gly Ser  Lys Met Trp 
    1685                 1690                 1695             


Ala Ser  Gln Arg Ala Ala Ser  Asn Phe Thr Glu Ile  Lys Asn Leu 
    1700                 1705                 1710             


Leu Val  Asn Thr Leu Tyr Thr  Val Arg Val Ala Ala  Val Thr Ser 
    1715                 1720                 1725             


Arg Gly  Ile Gly Asn Trp Ser  Asp Ser Lys Ser Ile  Thr Thr Ile 
    1730                 1735                 1740             


Lys Gly  Lys Val Ile Pro Pro  Pro Asp Ile His Ile  Asp Ser Tyr 
    1745                 1750                 1755             


Gly Glu  Asn Tyr Leu Ser Phe  Thr Leu Thr Met Glu  Ser Asp Ile 
    1760                 1765                 1770             


Lys Val  Asn Gly Tyr Val Val  Asn Leu Phe Trp Ala  Phe Asp Thr 
    1775                 1780                 1785             


His Lys  Gln Glu Arg Arg Thr  Leu Asn Phe Arg Gly  Ser Ile Leu 
    1790                 1795                 1800             


Ser His  Lys Val Gly Asn Leu  Thr Ala His Thr Ser  Tyr Glu Ile 
    1805                 1810                 1815             


Ser Ala  Trp Ala Lys Thr Asp  Leu Gly Asp Ser Pro  Leu Ala Phe 
    1820                 1825                 1830             


Glu His  Val Met Thr Arg Gly  Val Arg Pro Pro Ala  Pro Ser Leu 
    1835                 1840                 1845             


Lys Ala  Lys Ala Ile Asn Gln  Thr Ala Val Glu Cys  Thr Trp Thr 
    1850                 1855                 1860             


Gly Pro  Arg Asn Val Val Tyr  Gly Ile Phe Tyr Ala  Thr Ser Phe 
    1865                 1870                 1875             


Leu Asp  Leu Tyr Arg Asn Pro  Lys Ser Leu Thr Thr  Ser Leu His 
    1880                 1885                 1890             


Asn Lys  Thr Val Ile Val Ser  Lys Asp Glu Gln Tyr  Leu Phe Leu 
    1895                 1900                 1905             


Val Arg  Val Val Val Pro Tyr  Gln Gly Pro Ser Ser  Asp Tyr Val 
    1910                 1915                 1920             


Val Val  Lys Met Ile Pro Asp  Ser Arg Leu Pro Pro  Arg His Leu 
    1925                 1930                 1935             


His Val  Val His Thr Gly Lys  Thr Ser Val Val Ile  Lys Trp Glu 
    1940                 1945                 1950             


Ser Pro  Tyr Asp Ser Pro Asp  Gln Asp Leu Leu Tyr  Ala Ile Ala 
    1955                 1960                 1965             


Val Lys  Asp Leu Ile Arg Lys  Thr Asp Arg Ser Tyr  Lys Val Lys 
    1970                 1975                 1980             


Ser Arg  Asn Ser Thr Val Glu  Tyr Thr Leu Asn Lys  Leu Glu Pro 
    1985                 1990                 1995             


Gly Gly  Lys Tyr His Ile Ile  Val Gln Leu Gly Asn  Met Ser Lys 
    2000                 2005                 2010             


Asp Ser  Ser Ile Lys Ile Thr  Thr Val Ser Leu Ser  Ala Pro Asp 
    2015                 2020                 2025             


Ala Leu  Lys Ile Ile Thr Glu  Asn Asp His Val Leu  Leu Phe Trp 
    2030                 2035                 2040             


Lys Ser  Leu Ala Leu Lys Glu  Lys His Phe Asn Glu  Ser Arg Gly 
    2045                 2050                 2055             


Tyr Glu  Ile His Met Phe Asp  Ser Ala Met Asn Ile  Thr Ala Tyr 
    2060                 2065                 2070             


Leu Gly  Asn Thr Thr Asp Asn  Phe Phe Lys Ile Ser  Asn Leu Lys 
    2075                 2080                 2085             


Met Gly  His Asn Tyr Thr Phe  Thr Val Gln Ala Arg  Cys Leu Phe 
    2090                 2095                 2100             


Gly Asn  Gln Ile Cys Gly Glu  Pro Ala Ile Leu Leu  Tyr Asp Glu 
    2105                 2110                 2115             


Leu Gly  Ser Gly Ala Asp Ala  Ser Ala Thr Gln Ala  Ala Arg Ser 
    2120                 2125                 2130             


Thr Asp  Val Ala Ala Val Val  Val Pro Ile Leu Phe  Leu Ile Leu 
    2135                 2140                 2145             


Leu Ser  Leu Gly Val Gly Phe  Ala Ile Leu Tyr Thr  Lys His Arg 
    2150                 2155                 2160             


Arg Leu  Gln Ser Ser Phe Thr  Ala Phe Ala Asn Ser  His Tyr Ser 
    2165                 2170                 2175             


Ser Arg  Leu Gly Ser Ala Ile  Phe Ser Ser Gly Asp  Asp Leu Gly 
    2180                 2185                 2190             


Glu Asp  Asp Glu Asp Ala Pro  Met Ile Thr Gly Phe  Ser Asp Asp 
    2195                 2200                 2205             


Val Pro  Met Val Ile Ala 
    2210                 


<210>  2784
<211>  784
<212>  PRT
<213>  Homo sapiens

<400>  2784

Met Ser Asp Gln Lys Lys Glu Glu Glu Glu Glu Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Met Ala Thr Glu Gly Gly Lys Thr Ser Glu Pro Glu Asn Asn Asn 
            20                  25                  30          


Lys Lys Pro Lys Thr Ser Gly Ser Gln Asp Ser Gln Pro Ser Pro Leu 
        35                  40                  45              


Ala Leu Leu Ala Ala Thr Cys Ser Lys Ile Gly Thr Pro Gly Glu Asn 
    50                  55                  60                  


Gln Ala Thr Gly Gln Gln Gln Ile Ile Ile Asp Pro Ser Gln Gly Leu 
65                  70                  75                  80  


Val Gln Leu Gln Asn Gln Pro Gln Gln Leu Glu Leu Val Thr Thr Gln 
                85                  90                  95      


Leu Ala Gly Asn Ala Trp Gln Leu Val Ala Ser Thr Pro Pro Ala Ser 
            100                 105                 110         


Lys Glu Asn Asn Val Ser Gln Pro Ala Ser Ser Ser Ser Ser Ser Ser 
        115                 120                 125             


Ser Ser Asn Asn Gly Ser Ala Ser Pro Thr Lys Thr Lys Ser Gly Asn 
    130                 135                 140                 


Ser Ser Thr Pro Gly Gln Phe Gln Val Ile Gln Val Gln Asn Pro Ser 
145                 150                 155                 160 


Gly Ser Val Gln Tyr Gln Val Ile Pro Gln Leu Gln Thr Val Glu Gly 
                165                 170                 175     


Gln Gln Ile Gln Ile Asn Pro Thr Ser Ser Ser Ser Leu Gln Asp Leu 
            180                 185                 190         


Gln Gly Gln Ile Gln Leu Ile Ser Ala Gly Asn Asn Gln Ala Ile Leu 
        195                 200                 205             


Thr Ala Ala Asn Arg Thr Ala Ser Gly Asn Ile Leu Ala Gln Asn Leu 
    210                 215                 220                 


Ala Asn Gln Thr Val Pro Val Gln Ile Arg Pro Gly Val Ser Ile Pro 
225                 230                 235                 240 


Leu Gln Leu Gln Thr Leu Pro Gly Thr Gln Ala Gln Val Val Thr Thr 
                245                 250                 255     


Leu Pro Ile Asn Ile Gly Gly Val Thr Leu Ala Leu Pro Val Ile Asn 
            260                 265                 270         


Asn Val Ala Ala Gly Gly Gly Thr Gly Gln Val Gly Gln Pro Ala Ala 
        275                 280                 285             


Thr Ala Asp Ser Gly Thr Ser Asn Gly Asn Gln Leu Val Ser Thr Pro 
    290                 295                 300                 


Thr Asn Thr Thr Thr Ser Ala Ser Thr Met Pro Glu Ser Pro Ser Ser 
305                 310                 315                 320 


Ser Thr Thr Cys Thr Thr Thr Ala Ser Thr Ser Leu Thr Ser Ser Asp 
                325                 330                 335     


Thr Leu Val Ser Ser Ala Asp Thr Gly Gln Tyr Ala Ser Thr Ser Ala 
            340                 345                 350         


Ser Ser Ser Glu Arg Thr Ile Glu Glu Ser Gln Thr Pro Ala Ala Thr 
        355                 360                 365             


Glu Ser Glu Ala Gln Ser Ser Ser Gln Leu Gln Pro Asn Gly Met Gln 
    370                 375                 380                 


Asn Ala Gln Asp Gln Ser Asn Ser Leu Gln Gln Val Gln Ile Val Gly 
385                 390                 395                 400 


Gln Pro Ile Leu Gln Gln Ile Gln Ile Gln Gln Pro Gln Gln Gln Ile 
                405                 410                 415     


Ile Gln Ala Ile Pro Pro Gln Ser Phe Gln Leu Gln Ser Gly Gln Thr 
            420                 425                 430         


Ile Gln Thr Ile Gln Gln Gln Pro Leu Gln Asn Val Gln Leu Gln Ala 
        435                 440                 445             


Val Asn Pro Thr Gln Val Leu Ile Arg Ala Pro Thr Leu Thr Pro Ser 
    450                 455                 460                 


Gly Gln Ile Ser Trp Gln Thr Val Gln Val Gln Asn Ile Gln Ser Leu 
465                 470                 475                 480 


Ser Asn Leu Gln Val Gln Asn Ala Gly Leu Ser Gln Gln Leu Thr Ile 
                485                 490                 495     


Thr Pro Val Ser Ser Ser Gly Gly Thr Thr Leu Ala Gln Ile Ala Pro 
            500                 505                 510         


Val Ala Val Ala Gly Ala Pro Ile Thr Leu Asn Thr Ala Gln Leu Ala 
        515                 520                 525             


Ser Val Pro Asn Leu Gln Thr Val Ser Val Ala Asn Leu Gly Ala Ala 
    530                 535                 540                 


Gly Val Gln Val Gln Gly Val Pro Val Thr Ile Thr Ser Val Ala Gly 
545                 550                 555                 560 


Gln Gln Gln Gly Gln Asp Gly Val Lys Val Gln Gln Ala Thr Ile Ala 
                565                 570                 575     


Pro Val Thr Val Ala Val Gly Gly Ile Ala Asn Ala Thr Ile Gly Ala 
            580                 585                 590         


Val Ser Pro Asp Gln Leu Thr Gln Val His Leu Gln Gln Gly Gln Gln 
        595                 600                 605             


Thr Ser Asp Gln Glu Val Gln Pro Gly Lys Arg Leu Arg Arg Val Ala 
    610                 615                 620                 


Cys Ser Cys Pro Asn Cys Arg Glu Gly Glu Gly Arg Gly Ser Asn Glu 
625                 630                 635                 640 


Pro Gly Lys Lys Lys Gln His Ile Cys His Ile Glu Gly Cys Gly Lys 
                645                 650                 655     


Val Tyr Gly Lys Thr Ser His Leu Arg Ala His Leu Arg Trp His Thr 
            660                 665                 670         


Gly Glu Arg Pro Phe Ile Cys Asn Trp Met Phe Cys Gly Lys Arg Phe 
        675                 680                 685             


Thr Arg Ser Asp Glu Leu Gln Arg His Arg Arg Thr His Thr Gly Glu 
    690                 695                 700                 


Lys Arg Phe Glu Cys Pro Glu Cys Ser Lys Arg Phe Met Arg Ser Asp 
705                 710                 715                 720 


His Leu Ser Lys His Val Lys Thr His Gln Asn Lys Lys Gly Gly Gly 
                725                 730                 735     


Thr Ala Leu Ala Ile Val Thr Ser Gly Glu Leu Asp Ser Ser Val Thr 
            740                 745                 750         


Glu Val Leu Gly Ser Pro Arg Ile Val Thr Val Ala Ala Ile Ser Gln 
        755                 760                 765             


Asp Ser Asn Pro Ala Thr Pro Asn Val Ser Thr Asn Met Glu Glu Phe 
    770                 775                 780                 


<210>  2785
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  2785

Met Arg Arg Ser Ser Arg Pro Gly Ser Ala Ser Ser Ser Arg Lys His 
1               5                   10                  15      


Thr Pro Asn Phe Phe Ser Glu Asn Ser Ser Met Ser Ile Thr Ser Glu 
            20                  25                  30          


Asp Ser Lys Gly Leu Arg Ser Ala Glu Pro Gly Pro Gly Glu Pro Glu 
        35                  40                  45              


Gly Arg Arg Ala Arg Gly Pro Ser Cys Gly Glu Pro Ala Leu Ser Ala 
    50                  55                  60                  


Gly Val Pro Gly Gly Thr Thr Trp Ala Gly Ser Ser Gln Gln Lys Pro 
65                  70                  75                  80  


Ala Pro Arg Ser His Asn Trp Gln Thr Ala Cys Gly Ala Ala Thr Val 
                85                  90                  95      


Arg Gly Gly Ala Ser Glu Pro Thr Gly Ser Pro Val Val Ser Glu Glu 
            100                 105                 110         


Pro Leu Asp Leu Leu Pro Thr Leu Asp Leu Arg Gln Glu Met Pro Pro 
        115                 120                 125             


Pro Arg Val Phe Lys Ser Phe Leu Ser Leu Leu Phe Gln Gly Leu Ser 
    130                 135                 140                 


Val Leu Leu Ser Leu Ala Gly Asp Val Leu Val Ser Met Tyr Arg Glu 
145                 150                 155                 160 


Val Cys Ser Ile Arg Phe Leu Phe Thr Ala Val Ser Leu Leu Ser Leu 
                165                 170                 175     


Phe Leu Ser Ala Phe Trp Leu Gly Leu Leu Tyr Leu Val Ser Pro Leu 
            180                 185                 190         


Glu Asn Glu Pro Lys Glu Met Leu Thr Leu Ser Glu Tyr His Glu Arg 
        195                 200                 205             


Val Arg Ser Gln Gly Gln Gln Leu Gln Gln Leu Gln Ala Glu Leu Asp 
    210                 215                 220                 


Lys Leu His Lys Glu Val Ser Thr Val Arg Ala Ala Asn Ser Glu Arg 
225                 230                 235                 240 


Val Ala Lys Leu Val Phe Gln Arg Leu Asn Glu Asp Phe Val Arg Lys 
                245                 250                 255     


Pro Asp Tyr Ala Leu Ser Ser Val Gly Ala Ser Ile Asp Leu Gln Lys 
            260                 265                 270         


Thr Ser His Asp Tyr Ala Asp Arg Asn Thr Ala Tyr Phe Trp Asn Arg 
        275                 280                 285             


Phe Ser Phe Trp Asn Tyr Ala Arg Pro Pro Thr Val Ile Leu Glu Pro 
    290                 295                 300                 


His Val Phe Pro Gly Asn Cys Trp Ala Phe Glu Gly Asp Gln Gly Gln 
305                 310                 315                 320 


Val Val Ile Gln Leu Pro Gly Arg Val Gln Leu Ser Asp Ile Thr Leu 
                325                 330                 335     


Gln His Pro Pro Pro Ser Val Glu His Thr Gly Gly Ala Asn Ser Ala 
            340                 345                 350         


Pro Arg Asp Phe Ala Val Phe Gly Leu Gln Val Tyr Asp Glu Thr Glu 
        355                 360                 365             


Val Ser Leu Gly Lys Phe Thr Phe Asp Val Glu Lys Ser Glu Ile Gln 
    370                 375                 380                 


Thr Phe His Leu Gln Asn Asp Pro Pro Ala Ala Phe Pro Lys Val Lys 
385                 390                 395                 400 


Ile Gln Ile Leu Ser Asn Trp Gly His Pro Arg Phe Thr Cys Leu Tyr 
                405                 410                 415     


Arg Val Arg Ala His Gly Val Arg Thr Ser Glu Gly Ala Glu Gly Ser 
            420                 425                 430         


Ala Gln Gly Pro His 
        435         


<210>  2786
<211>  511
<212>  PRT
<213>  Homo sapiens

<400>  2786

Met Gly Val Leu Lys Phe Lys His Ile Phe Phe Arg Ser Phe Val Lys 
1               5                   10                  15      


Ser Ser Gly Val Ser Gln Ile Val Phe Thr Phe Leu Leu Ile Pro Cys 
            20                  25                  30          


Cys Leu Thr Leu Asn Phe Arg Ala Pro Pro Val Ile Pro Asn Val Pro 
        35                  40                  45              


Phe Leu Trp Ala Trp Asn Ala Pro Ser Glu Phe Cys Leu Gly Lys Phe 
    50                  55                  60                  


Asp Glu Pro Leu Asp Met Ser Leu Phe Ser Phe Ile Gly Ser Pro Arg 
65                  70                  75                  80  


Ile Asn Ala Thr Gly Gln Gly Val Thr Ile Phe Tyr Val Asp Arg Leu 
                85                  90                  95      


Gly Tyr Tyr Pro Tyr Ile Asp Ser Ile Thr Gly Val Thr Val Asn Gly 
            100                 105                 110         


Gly Ile Pro Gln Lys Ile Ser Leu Gln Asp His Leu Asp Lys Ala Lys 
        115                 120                 125             


Lys Asp Ile Thr Phe Tyr Met Pro Val Asp Asn Leu Gly Met Ala Val 
    130                 135                 140                 


Ile Asp Trp Glu Glu Trp Arg Pro Thr Trp Ala Arg Asn Trp Lys Pro 
145                 150                 155                 160 


Lys Asp Val Tyr Lys Asn Arg Ser Ile Glu Leu Val Gln Gln Gln Asn 
                165                 170                 175     


Val Gln Leu Ser Leu Thr Glu Ala Thr Glu Lys Ala Lys Gln Glu Phe 
            180                 185                 190         


Glu Lys Ala Gly Lys Asp Phe Leu Val Glu Thr Ile Lys Leu Gly Lys 
        195                 200                 205             


Leu Leu Arg Pro Asn His Leu Trp Gly Tyr Tyr Leu Phe Pro Asp Cys 
    210                 215                 220                 


Tyr Asn His His Tyr Lys Lys Pro Gly Tyr Asn Gly Ser Cys Phe Asn 
225                 230                 235                 240 


Val Glu Ile Lys Arg Asn Asp Asp Leu Ser Trp Leu Trp Asn Glu Ser 
                245                 250                 255     


Thr Ala Leu Tyr Pro Ser Ile Tyr Leu Asn Thr Gln Gln Ser Pro Val 
            260                 265                 270         


Ala Ala Thr Leu Tyr Val Arg Asn Arg Val Arg Glu Ala Ile Arg Val 
        275                 280                 285             


Ser Lys Ile Pro Asp Ala Lys Ser Pro Leu Pro Val Phe Ala Tyr Thr 
    290                 295                 300                 


Arg Ile Val Phe Thr Asp Gln Val Leu Lys Phe Leu Ser Gln Asp Glu 
305                 310                 315                 320 


Leu Val Tyr Thr Phe Gly Glu Thr Val Ala Leu Gly Ala Ser Gly Ile 
                325                 330                 335     


Val Ile Trp Gly Thr Leu Ser Ile Met Arg Ser Met Lys Ser Cys Leu 
            340                 345                 350         


Leu Leu Asp Asn Tyr Met Glu Thr Ile Leu Asn Pro Tyr Ile Ile Asn 
        355                 360                 365             


Val Thr Leu Ala Ala Lys Met Cys Ser Gln Val Leu Cys Gln Glu Gln 
    370                 375                 380                 


Gly Val Cys Ile Arg Lys Asn Trp Asn Ser Ser Asp Tyr Leu His Leu 
385                 390                 395                 400 


Asn Pro Asp Asn Phe Ala Ile Gln Leu Glu Lys Gly Gly Lys Phe Thr 
                405                 410                 415     


Val Arg Gly Lys Pro Thr Leu Glu Asp Leu Glu Gln Phe Ser Glu Lys 
            420                 425                 430         


Phe Tyr Cys Ser Cys Tyr Ser Thr Leu Ser Cys Lys Glu Lys Ala Asp 
        435                 440                 445             


Val Lys Asp Thr Asp Ala Val Asp Val Cys Ile Ala Asp Gly Val Cys 
    450                 455                 460                 


Ile Asp Ala Phe Leu Lys Pro Pro Met Glu Thr Glu Glu Pro Gln Ile 
465                 470                 475                 480 


Phe Tyr Asn Ala Ser Pro Ser Thr Leu Ser Ala Thr Met Phe Ile Trp 
                485                 490                 495     


Arg Leu Glu Val Trp Asp Gln Gly Ile Ser Arg Ile Gly Phe Phe 
            500                 505                 510     


<210>  2787
<211>  795
<212>  PRT
<213>  Homo sapiens

<400>  2787

Met Ala Val Leu Leu Leu Leu Leu Arg Ala Leu Arg Arg Gly Pro Gly 
1               5                   10                  15      


Pro Gly Pro Arg Pro Leu Trp Gly Pro Gly Pro Ala Trp Ser Pro Gly 
            20                  25                  30          


Phe Pro Ala Arg Pro Gly Arg Gly Arg Pro Tyr Met Ala Ser Arg Pro 
        35                  40                  45              


Pro Gly Asp Leu Ala Glu Ala Gly Gly Arg Ala Leu Gln Ser Leu Gln 
    50                  55                  60                  


Leu Arg Leu Leu Thr Pro Thr Phe Glu Gly Ile Asn Gly Leu Leu Leu 
65                  70                  75                  80  


Lys Gln His Leu Val Gln Asn Pro Val Arg Leu Trp Gln Leu Leu Gly 
                85                  90                  95      


Gly Thr Phe Tyr Phe Asn Thr Ser Arg Leu Lys Gln Lys Asn Lys Glu 
            100                 105                 110         


Lys Asp Lys Ser Lys Gly Lys Ala Pro Glu Glu Asp Glu Glu Glu Arg 
        115                 120                 125             


Arg Arg Arg Glu Arg Asp Asp Gln Met Tyr Arg Glu Arg Leu Arg Thr 
    130                 135                 140                 


Leu Leu Val Ile Ala Val Val Met Ser Leu Leu Asn Ala Leu Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Ser Ile Ser Trp Asn Asp Phe Val His Glu Met Leu Ala 
                165                 170                 175     


Lys Gly Glu Val Gln Arg Val Gln Val Val Pro Glu Ser Asp Val Val 
            180                 185                 190         


Glu Val Tyr Leu His Pro Gly Ala Val Val Phe Gly Arg Pro Arg Leu 
        195                 200                 205             


Ala Leu Met Tyr Arg Met Gln Val Ala Asn Ile Asp Lys Phe Glu Glu 
    210                 215                 220                 


Lys Leu Arg Ala Ala Glu Asp Glu Leu Asn Ile Glu Ala Lys Asp Arg 
225                 230                 235                 240 


Ile Pro Val Ser Tyr Lys Arg Thr Gly Phe Phe Gly Asn Ala Leu Tyr 
                245                 250                 255     


Ser Val Gly Met Thr Ala Val Gly Leu Ala Ile Leu Trp Tyr Val Phe 
            260                 265                 270         


Arg Leu Ala Gly Met Thr Gly Arg Glu Gly Gly Phe Ser Ala Phe Asn 
        275                 280                 285             


Gln Leu Lys Met Ala Arg Phe Thr Ile Val Asp Gly Lys Met Gly Lys 
    290                 295                 300                 


Gly Val Ser Phe Lys Asp Val Ala Gly Met His Glu Ala Lys Leu Glu 
305                 310                 315                 320 


Val Arg Glu Phe Val Asp Tyr Leu Lys Ser Pro Glu Arg Phe Leu Gln 
                325                 330                 335     


Leu Gly Ala Lys Val Pro Lys Gly Ala Leu Leu Leu Gly Pro Pro Gly 
            340                 345                 350         


Cys Gly Lys Thr Leu Leu Ala Lys Ala Val Ala Thr Glu Ala Gln Val 
        355                 360                 365             


Pro Phe Leu Ala Met Ala Gly Pro Glu Phe Val Glu Val Ile Gly Gly 
    370                 375                 380                 


Leu Gly Ala Ala Arg Val Arg Ser Leu Phe Lys Glu Ala Arg Ala Arg 
385                 390                 395                 400 


Ala Pro Cys Ile Val Tyr Ile Asp Glu Ile Asp Ala Val Gly Lys Lys 
                405                 410                 415     


Arg Ser Thr Thr Met Ser Gly Phe Ser Asn Thr Glu Glu Glu Gln Thr 
            420                 425                 430         


Leu Asn Gln Leu Leu Val Glu Met Asp Gly Met Gly Thr Thr Asp His 
        435                 440                 445             


Val Ile Val Leu Ala Ser Thr Asn Arg Ala Asp Ile Leu Asp Gly Ala 
    450                 455                 460                 


Leu Met Arg Pro Gly Arg Leu Asp Arg His Val Phe Ile Asp Leu Pro 
465                 470                 475                 480 


Thr Leu Gln Glu Arg Arg Glu Ile Phe Glu Gln His Leu Lys Ser Leu 
                485                 490                 495     


Lys Leu Thr Gln Ser Ser Thr Phe Tyr Ser Gln Arg Leu Ala Glu Leu 
            500                 505                 510         


Thr Pro Gly Phe Ser Gly Ala Asp Ile Ala Asn Ile Cys Asn Glu Ala 
        515                 520                 525             


Ala Leu His Ala Ala Arg Glu Gly His Thr Ser Val His Thr Leu Asn 
    530                 535                 540                 


Phe Glu Tyr Ala Val Glu Arg Val Leu Ala Gly Thr Ala Lys Lys Ser 
545                 550                 555                 560 


Lys Ile Leu Ser Lys Glu Glu Gln Lys Val Val Ala Phe His Glu Ser 
                565                 570                 575     


Gly His Ala Leu Val Gly Trp Met Leu Glu His Thr Glu Ala Val Met 
            580                 585                 590         


Lys Val Ser Ile Thr Pro Arg Thr Asn Ala Ala Leu Gly Phe Ala Gln 
        595                 600                 605             


Met Leu Pro Arg Asp Gln His Leu Phe Thr Lys Glu Gln Leu Phe Glu 
    610                 615                 620                 


Arg Met Cys Met Ala Leu Gly Gly Arg Ala Ser Glu Ala Leu Ser Phe 
625                 630                 635                 640 


Asn Glu Val Thr Ser Gly Ala Gln Asp Asp Leu Arg Lys Val Thr Arg 
                645                 650                 655     


Ile Ala Tyr Ser Met Val Lys Gln Phe Gly Met Ala Pro Gly Ile Gly 
            660                 665                 670         


Pro Ile Ser Phe Pro Glu Ala Gln Glu Gly Leu Met Gly Ile Gly Arg 
        675                 680                 685             


Arg Pro Phe Ser Gln Gly Leu Gln Gln Met Met Asp His Glu Ala Arg 
    690                 695                 700                 


Leu Leu Val Ala Lys Ala Tyr Arg His Thr Glu Lys Val Leu Gln Asp 
705                 710                 715                 720 


Asn Leu Asp Lys Leu Gln Ala Leu Ala Asn Ala Leu Leu Glu Lys Glu 
                725                 730                 735     


Val Ile Asn Tyr Glu Asp Ile Glu Ala Leu Ile Gly Pro Pro Pro His 
            740                 745                 750         


Gly Pro Lys Lys Met Ile Ala Pro Gln Arg Trp Ile Asp Ala Gln Arg 
        755                 760                 765             


Glu Lys Gln Asp Leu Gly Glu Glu Glu Thr Glu Glu Thr Gln Gln Pro 
    770                 775                 780                 


Pro Leu Gly Gly Glu Glu Pro Thr Trp Pro Lys 
785                 790                 795 


<210>  2788
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  2788

Met Leu Gln Ala Cys Lys Met Glu Gly Phe Pro Leu Val Pro Pro Pro 
1               5                   10                  15      


Ser Glu Asp Leu Val Pro Tyr Asp Thr Asp Leu Tyr Gln Arg Gln Thr 
            20                  25                  30          


His Glu Tyr Tyr Pro Tyr Leu Ser Ser Asp Gly Glu Ser His Ser Asp 
        35                  40                  45              


His Tyr Trp Asp Phe His Pro His His Val His Ser Glu Phe Glu Ser 
    50                  55                  60                  


Phe Ala Glu Asn Asn Phe Thr Glu Leu Gln Ser Val Gln Pro Pro Gln 
65                  70                  75                  80  


Leu Gln Gln Leu Tyr Arg His Met Glu Leu Glu Gln Met His Val Leu 
                85                  90                  95      


Asp Thr Pro Met Val Pro Pro His Pro Ser Leu Gly His Gln Val Ser 
            100                 105                 110         


Tyr Leu Pro Arg Met Cys Leu Gln Tyr Pro Ser Leu Ser Pro Ala Gln 
        115                 120                 125             


Pro Ser Ser Asp Glu Glu Glu Gly Glu Arg Gln Ser Pro Pro Leu Glu 
    130                 135                 140                 


Val Ser Asp Gly Glu Ala Asp Gly Leu Glu Pro Gly Pro Gly Leu Leu 
145                 150                 155                 160 


Pro Gly Glu Thr Gly Ser Lys Lys Lys Ile Arg Leu Tyr Gln Phe Leu 
                165                 170                 175     


Leu Asp Leu Leu Arg Ser Gly Asp Met Lys Asp Ser Ile Trp Trp Val 
            180                 185                 190         


Asp Lys Asp Lys Gly Thr Phe Gln Phe Ser Ser Lys His Lys Glu Ala 
        195                 200                 205             


Leu Ala His Arg Trp Gly Ile Gln Lys Gly Asn Arg Lys Lys Met Thr 
    210                 215                 220                 


Tyr Gln Lys Met Ala Arg Ala Leu Arg Asn Tyr Gly Lys Thr Gly Glu 
225                 230                 235                 240 


Val Lys Lys Val Lys Lys Lys Leu Thr Tyr Gln Phe Ser Gly Glu Val 
                245                 250                 255     


Leu Gly Arg Gly Gly Leu Ala Glu Arg Arg His Pro Pro His 
            260                 265                 270 


<210>  2789
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  2789

Met Ala Thr Leu Leu Leu Leu Leu Gly Val Leu Val Val Ser Pro Asp 
1               5                   10                  15      


Ala Leu Gly Ser Thr Thr Ala Val Gln Thr Pro Thr Ser Gly Glu Pro 
            20                  25                  30          


Leu Val Ser Thr Ser Glu Pro Leu Ser Ser Lys Met Tyr Thr Thr Ser 
        35                  40                  45              


Ile Thr Ser Asp Pro Lys Ala Asp Ser Thr Gly Asp Gln Thr Ser Ala 
    50                  55                  60                  


Leu Pro Pro Ser Thr Ser Ile Asn Glu Gly Ser Pro Leu Trp Thr Ser 
65                  70                  75                  80  


Ile Gly Ala Ser Thr Gly Ser Pro Leu Pro Glu Pro Thr Thr Tyr Gln 
                85                  90                  95      


Glu Val Ser Ile Lys Met Ser Ser Val Pro Gln Glu Thr Pro His Ala 
            100                 105                 110         


Thr Ser His Pro Ala Val Pro Ile Thr Ala Asn Ser Leu Gly Ser His 
        115                 120                 125             


Thr Val Thr Gly Gly Thr Ile Thr Thr Asn Ser Pro Glu Thr Ser Ser 
    130                 135                 140                 


Arg Thr Ser Gly Ala Pro Val Thr Thr Ala Ala Ser Ser Leu Glu Thr 
145                 150                 155                 160 


Ser Arg Gly Thr Ser Gly Pro Pro Leu Thr Met Ala Thr Val Ser Leu 
                165                 170                 175     


Glu Thr Ser Lys Gly Thr Ser Gly Pro Pro Val Thr Met Ala Thr Asp 
            180                 185                 190         


Ser Leu Glu Thr Ser Thr Gly Thr Thr Gly Pro Pro Val Thr Met Thr 
        195                 200                 205             


Thr Gly Ser Leu Glu Pro Ser Ser Gly Ala Ser Gly Pro Gln Val Ser 
    210                 215                 220                 


Ser Val Lys Leu Ser Thr Met Met Ser Pro Thr Thr Ser Thr Asn Ala 
225                 230                 235                 240 


Ser Thr Val Pro Phe Arg Asn Pro Asp Glu Asn Ser Arg Gly Met Leu 
                245                 250                 255     


Pro Val Ala Val Leu Val Ala Leu Leu Ala Val Ile Val Leu Val Ala 
            260                 265                 270         


Leu Leu Leu Leu Trp Arg Arg Arg Gln Lys Arg Arg Thr Gly Ala Leu 
        275                 280                 285             


Val Leu Ser Arg Gly Gly Lys Arg Asn Gly Val Val Asp Ala Trp Ala 
    290                 295                 300                 


Gly Pro Ala Gln Val Pro Glu Glu Gly Ala Val Thr Val Thr Val Gly 
305                 310                 315                 320 


Gly Ser Gly Gly Asp Lys Gly Ser Gly Phe Pro Asp Gly Glu Gly Ser 
                325                 330                 335     


Ser Arg Arg Pro Thr Leu Thr Thr Phe Phe Gly Arg Arg Lys Ser Arg 
            340                 345                 350         


Gln Gly Ser Leu Ala Met Glu Glu Leu Lys Ser Gly Ser Gly Pro Ser 
        355                 360                 365             


Leu Lys Gly Glu Glu Glu Pro Leu Val Ala Ser Glu Asp Gly Ala Val 
    370                 375                 380                 


Asp Ala Pro Ala Pro Asp Glu Pro Glu Gly Gly Asp Gly Ala Ala Pro 
385                 390                 395                 400 


<210>  2790
<211>  574
<212>  PRT
<213>  Homo sapiens

<400>  2790

Met Trp Thr Phe Leu Gly Ile Ala Thr Phe Thr Tyr Phe Tyr Lys Lys 
1               5                   10                  15      


Phe Gly Asp Phe Ile Thr Leu Ala Asn Arg Glu Val Leu Leu Cys Val 
            20                  25                  30          


Leu Val Phe Leu Ser Leu Gly Leu Val Leu Ser Tyr Arg Cys Arg His 
        35                  40                  45              


Arg Asn Gly Gly Leu Leu Gly Arg Gln Gln Ser Gly Ser Gln Phe Ala 
    50                  55                  60                  


Leu Phe Ser Asp Ile Leu Ser Gly Leu Pro Phe Ile Gly Phe Phe Trp 
65                  70                  75                  80  


Ala Lys Ser Pro Pro Glu Ser Glu Asn Lys Glu Gln Leu Glu Ala Arg 
                85                  90                  95      


Arg Arg Arg Lys Gly Thr Asn Ile Ser Glu Thr Ser Leu Ile Gly Thr 
            100                 105                 110         


Ala Ala Cys Thr Ser Thr Ser Ser Gln Asn Asp Pro Glu Val Ile Ile 
        115                 120                 125             


Val Gly Ala Gly Val Leu Gly Ser Ala Leu Ala Ala Val Leu Ser Arg 
    130                 135                 140                 


Asp Gly Arg Lys Val Thr Val Ile Glu Arg Asp Leu Lys Glu Pro Asp 
145                 150                 155                 160 


Arg Ile Val Gly Glu Phe Leu Gln Pro Gly Gly Tyr His Val Leu Lys 
                165                 170                 175     


Asp Leu Gly Leu Gly Asp Thr Val Glu Gly Leu Asp Ala Gln Val Val 
            180                 185                 190         


Asn Gly Tyr Met Ile His Asp Gln Glu Ser Lys Ser Glu Val Gln Ile 
        195                 200                 205             


Pro Tyr Pro Leu Ser Glu Asn Asn Gln Val Gln Ser Gly Arg Ala Phe 
    210                 215                 220                 


His His Gly Arg Phe Ile Met Ser Leu Arg Lys Ala Ala Met Ala Glu 
225                 230                 235                 240 


Pro Asn Ala Lys Phe Ile Glu Gly Val Val Leu Gln Leu Leu Glu Glu 
                245                 250                 255     


Asp Asp Val Val Met Gly Val Gln Tyr Lys Asp Lys Glu Thr Gly Asp 
            260                 265                 270         


Ile Lys Glu Leu His Ala Pro Leu Thr Val Val Ala Asp Gly Leu Phe 
        275                 280                 285             


Ser Lys Phe Arg Lys Ser Leu Val Ser Asn Lys Val Ser Val Ser Ser 
    290                 295                 300                 


His Phe Val Gly Phe Leu Met Lys Asn Ala Pro Gln Phe Lys Ala Asn 
305                 310                 315                 320 


His Ala Glu Leu Ile Leu Ala Asn Pro Ser Pro Val Leu Ile Tyr Gln 
                325                 330                 335     


Ile Ser Ser Ser Glu Thr Arg Val Leu Val Asp Ile Arg Gly Glu Met 
            340                 345                 350         


Pro Arg Asn Leu Arg Glu Tyr Met Val Glu Lys Ile Tyr Pro Gln Ile 
        355                 360                 365             


Pro Asp His Leu Lys Glu Pro Phe Leu Glu Ala Thr Asp Asn Ser His 
    370                 375                 380                 


Leu Arg Ser Met Pro Ala Ser Phe Leu Pro Pro Ser Ser Val Lys Lys 
385                 390                 395                 400 


Arg Gly Val Leu Leu Leu Gly Asp Ala Tyr Asn Met Arg His Pro Leu 
                405                 410                 415     


Thr Gly Gly Gly Met Thr Val Ala Phe Lys Asp Ile Lys Leu Trp Arg 
            420                 425                 430         


Lys Leu Leu Lys Gly Ile Pro Asp Leu Tyr Asp Asp Ala Ala Ile Phe 
        435                 440                 445             


Glu Ala Lys Lys Ser Phe Tyr Trp Ala Arg Lys Thr Ser His Ser Phe 
    450                 455                 460                 


Val Val Asn Ile Leu Ala Gln Ala Leu Tyr Glu Leu Phe Ser Ala Thr 
465                 470                 475                 480 


Asp Asp Ser Leu His Gln Leu Arg Lys Ala Cys Phe Leu Tyr Phe Lys 
                485                 490                 495     


Leu Gly Gly Glu Cys Val Ala Gly Pro Val Gly Leu Leu Ser Val Leu 
            500                 505                 510         


Ser Pro Asn Pro Leu Val Leu Ile Gly His Phe Phe Ala Val Ala Ile 
        515                 520                 525             


Tyr Ala Val Tyr Phe Cys Phe Lys Ser Glu Pro Trp Ile Thr Lys Pro 
    530                 535                 540                 


Arg Ala Leu Leu Ser Ser Gly Ala Val Leu Tyr Lys Ala Cys Ser Val 
545                 550                 555                 560 


Ile Phe Pro Leu Ile Tyr Ser Glu Met Lys Tyr Met Val His 
                565                 570                 


<210>  2791
<211>  286
<212>  PRT
<213>  Homo sapiens

<400>  2791

Met Arg Leu Leu Pro Arg Leu Leu Leu Leu Leu Leu Leu Val Phe Pro 
1               5                   10                  15      


Ala Thr Val Leu Phe Arg Gly Gly Pro Arg Gly Leu Leu Ala Val Ala 
            20                  25                  30          


Gln Asp Leu Thr Glu Asp Glu Glu Thr Val Glu Asp Ser Ile Ile Glu 
        35                  40                  45              


Asp Glu Asp Asp Glu Ala Glu Val Glu Glu Asp Glu Pro Thr Asp Leu 
    50                  55                  60                  


Val Glu Asp Lys Glu Glu Glu Asp Val Ser Gly Glu Pro Glu Ala Ser 
65                  70                  75                  80  


Pro Ser Ala Asp Thr Thr Ile Leu Phe Val Lys Gly Glu Asp Phe Pro 
                85                  90                  95      


Ala Asn Asn Ile Val Lys Phe Leu Val Gly Phe Thr Asn Lys Gly Thr 
            100                 105                 110         


Glu Asp Phe Ile Val Glu Ser Leu Asp Ala Ser Phe Arg Tyr Pro Gln 
        115                 120                 125             


Asp Tyr Gln Phe Tyr Ile Gln Asn Phe Thr Ala Leu Pro Leu Asn Thr 
    130                 135                 140                 


Val Val Pro Pro Gln Arg Gln Ala Thr Phe Glu Tyr Ser Phe Ile Pro 
145                 150                 155                 160 


Ala Glu Pro Met Gly Gly Arg Pro Phe Gly Leu Val Ile Asn Leu Asn 
                165                 170                 175     


Tyr Lys Asp Leu Asn Gly Asn Val Phe Gln Asp Ala Val Phe Asn Gln 
            180                 185                 190         


Thr Val Thr Val Ile Glu Arg Glu Asp Gly Leu Asp Gly Glu Thr Ile 
        195                 200                 205             


Phe Met Tyr Met Phe Leu Ala Gly Leu Gly Leu Leu Val Ile Val Gly 
    210                 215                 220                 


Leu His Gln Leu Leu Glu Ser Arg Lys Arg Lys Arg Pro Ile Gln Lys 
225                 230                 235                 240 


Val Glu Met Gly Thr Ser Ser Gln Asn Asp Val Asp Met Ser Trp Ile 
                245                 250                 255     


Pro Gln Glu Thr Leu Asn Gln Ile Asn Lys Ala Ser Pro Arg Arg Leu 
            260                 265                 270         


Pro Arg Lys Arg Ala Gln Lys Arg Ser Val Gly Ser Asp Glu 
        275                 280                 285     


<210>  2792
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  2792

Met Arg Leu Leu Ser Phe Val Val Leu Ala Leu Phe Ala Val Thr Gln 
1               5                   10                  15      


Ala Glu Glu Gly Ala Arg Leu Leu Ala Ser Lys Ser Leu Leu Asn Arg 
            20                  25                  30          


Tyr Ala Val Glu Gly Arg Asp Leu Thr Leu Gln Tyr Asn Ile Tyr Asn 
        35                  40                  45              


Val Gly Ser Ser Ala Ala Leu Asp Val Glu Leu Ser Asp Asp Ser Phe 
    50                  55                  60                  


Pro Pro Glu Asp Phe Gly Ile Val Ser Gly Met Leu Asn Val Lys Trp 
65                  70                  75                  80  


Asp Arg Ile Ala Pro Ala Ser Asn Val Ser His Thr Val Val Leu Arg 
                85                  90                  95      


Pro Leu Lys Ala Gly Tyr Phe Asn Phe Thr Ser Ala Thr Ile Thr Tyr 
            100                 105                 110         


Leu Ala Gln Glu Asp Gly Pro Val Val Ile Gly Ser Thr Ser Ala Pro 
        115                 120                 125             


Gly Gln Gly Gly Ile Leu Ala Gln Arg Glu Phe Asp Arg Arg Phe Ser 
    130                 135                 140                 


Pro His Phe Leu Asp Trp Ala Ala Phe Gly Val Met Thr Leu Pro Ser 
145                 150                 155                 160 


Ile Gly Ile Pro Leu Leu Leu Trp Tyr Ser Ser Lys Arg Lys Tyr Asp 
                165                 170                 175     


Thr Pro Lys Thr Lys Lys Asn 
            180             


<210>  2793
<211>  685
<212>  PRT
<213>  Homo sapiens

<400>  2793

Met Asp Val Cys Val Arg Leu Ala Leu Trp Leu Leu Trp Gly Leu Leu 
1               5                   10                  15      


Leu His Gln Gly Gln Ser Leu Ser His Ser His Ser Glu Lys Ala Thr 
            20                  25                  30          


Gly Thr Ser Ser Gly Ala Asn Ser Glu Glu Ser Thr Ala Ala Glu Phe 
        35                  40                  45              


Cys Arg Ile Asp Lys Pro Leu Cys His Ser Glu Asp Glu Lys Leu Ser 
    50                  55                  60                  


Phe Glu Ala Val Arg Asn Ile His Lys Leu Met Asp Asp Asp Ala Asn 
65                  70                  75                  80  


Gly Asp Val Asp Val Glu Glu Ser Asp Glu Phe Leu Arg Glu Asp Leu 
                85                  90                  95      


Asn Tyr His Asp Pro Thr Val Lys His Ser Thr Phe His Gly Glu Asp 
            100                 105                 110         


Lys Leu Ile Ser Val Glu Asp Leu Trp Lys Ala Trp Lys Ser Ser Glu 
        115                 120                 125             


Val Tyr Asn Trp Thr Val Asp Glu Val Val Gln Trp Leu Ile Thr Tyr 
    130                 135                 140                 


Val Glu Leu Pro Gln Tyr Glu Glu Thr Phe Arg Lys Leu Gln Leu Ser 
145                 150                 155                 160 


Gly His Ala Met Pro Arg Leu Ala Val Thr Asn Thr Thr Met Thr Gly 
                165                 170                 175     


Thr Val Leu Lys Met Thr Asp Arg Ser His Arg Gln Lys Leu Gln Leu 
            180                 185                 190         


Lys Ala Leu Asp Thr Val Leu Phe Gly Pro Pro Leu Leu Thr Arg His 
        195                 200                 205             


Asn His Leu Lys Asp Phe Met Leu Val Val Ser Ile Val Ile Gly Val 
    210                 215                 220                 


Gly Gly Cys Trp Phe Ala Tyr Ile Gln Asn Arg Tyr Ser Lys Glu His 
225                 230                 235                 240 


Met Lys Lys Met Met Lys Asp Leu Glu Gly Leu His Arg Ala Glu Gln 
                245                 250                 255     


Ser Leu His Asp Leu Gln Glu Arg Leu His Lys Ala Gln Glu Glu His 
            260                 265                 270         


Arg Thr Val Glu Val Glu Lys Val His Leu Glu Lys Lys Leu Arg Asp 
        275                 280                 285             


Glu Ile Asn Leu Ala Lys Gln Glu Ala Gln Arg Leu Lys Glu Leu Arg 
    290                 295                 300                 


Glu Gly Thr Glu Asn Glu Arg Ser Arg Gln Lys Tyr Ala Glu Glu Glu 
305                 310                 315                 320 


Leu Glu Gln Val Arg Glu Ala Leu Arg Lys Ala Glu Lys Glu Leu Glu 
                325                 330                 335     


Ser His Ser Ser Trp Tyr Ala Pro Glu Ala Leu Gln Lys Trp Leu Gln 
            340                 345                 350         


Leu Thr His Glu Val Glu Val Gln Tyr Tyr Asn Ile Lys Lys Gln Asn 
        355                 360                 365             


Ala Glu Lys Gln Leu Leu Val Ala Lys Glu Gly Ala Glu Lys Ile Lys 
    370                 375                 380                 


Lys Lys Arg Asn Thr Leu Phe Gly Thr Phe His Val Ala His Ser Ser 
385                 390                 395                 400 


Ser Leu Asp Asp Val Asp His Lys Ile Leu Thr Ala Lys Gln Ala Leu 
                405                 410                 415     


Ser Glu Val Thr Ala Ala Leu Arg Glu Arg Leu His Arg Trp Gln Gln 
            420                 425                 430         


Ile Glu Ile Leu Cys Gly Phe Gln Ile Val Asn Asn Pro Gly Ile His 
        435                 440                 445             


Ser Leu Val Ala Ala Leu Asn Ile Asp Pro Ser Trp Met Gly Ser Thr 
    450                 455                 460                 


Arg Pro Asn Pro Ala His Phe Ile Met Thr Asp Asp Val Asp Asp Met 
465                 470                 475                 480 


Asp Glu Glu Ile Val Ser Pro Leu Ser Met Gln Ser Pro Ser Leu Gln 
                485                 490                 495     


Ser Ser Val Arg Gln Arg Leu Thr Glu Pro Gln His Gly Leu Gly Ser 
            500                 505                 510         


Gln Arg Asp Leu Thr His Ser Asp Ser Glu Ser Ser Leu His Met Ser 
        515                 520                 525             


Asp Arg Gln Arg Val Ala Pro Lys Pro Pro Gln Met Ser Arg Ala Ala 
    530                 535                 540                 


Asp Glu Ala Leu Asn Ala Met Thr Ser Asn Gly Ser His Arg Leu Ile 
545                 550                 555                 560 


Glu Gly Val His Pro Gly Ser Leu Val Glu Lys Leu Pro Asp Ser Pro 
                565                 570                 575     


Ala Leu Ala Lys Lys Ala Leu Leu Ala Leu Asn His Gly Leu Asp Lys 
            580                 585                 590         


Ala His Ser Leu Met Glu Leu Ser Pro Ser Ala Pro Pro Gly Gly Ser 
        595                 600                 605             


Pro His Leu Asp Ser Ser Arg Ser His Ser Pro Ser Ser Pro Asp Pro 
    610                 615                 620                 


Asp Thr Pro Ser Pro Val Gly Asp Ser Arg Ala Leu Gln Ala Ser Arg 
625                 630                 635                 640 


Asn Thr Arg Ile Pro His Leu Ala Gly Lys Lys Ala Val Ala Glu Glu 
                645                 650                 655     


Asp Asn Gly Ser Ile Gly Glu Glu Thr Asp Ser Ser Pro Gly Arg Lys 
            660                 665                 670         


Lys Phe Pro Leu Lys Ile Phe Lys Lys Pro Leu Lys Lys 
        675                 680                 685 


<210>  2794
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  2794

Met Leu Leu Leu Ala Asp Met Asp Val Val Asn Gln Leu Val Ala Gly 
1               5                   10                  15      


Gly Gln Phe Arg Val Val Lys Glu Pro Leu Gly Phe Val Lys Val Leu 
            20                  25                  30          


Gln Trp Val Phe Ala Ile Phe Ala Phe Ala Thr Cys Gly Ser Tyr Ser 
        35                  40                  45              


Gly Glu Leu Gln Leu Ser Val Asp Cys Ala Asn Lys Thr Glu Ser Asp 
    50                  55                  60                  


Leu Ser Ile Glu Val Glu Phe Glu Tyr Pro Phe Arg Leu His Gln Val 
65                  70                  75                  80  


Tyr Phe Asp Ala Pro Thr Cys Arg Gly Gly Thr Thr Lys Val Phe Leu 
                85                  90                  95      


Val Gly Asp Tyr Ser Ser Ser Ala Glu Phe Phe Val Thr Val Ala Val 
            100                 105                 110         


Phe Ala Phe Leu Tyr Ser Met Gly Ala Leu Ala Thr Tyr Ile Phe Leu 
        115                 120                 125             


Gln Asn Lys Tyr Arg Glu Asn Asn Lys Gly Pro Met Leu Asp Phe Leu 
    130                 135                 140                 


Ala Thr Ala Val Phe Ala Phe Met Trp Leu Val Ser Ser Ser Ala Trp 
145                 150                 155                 160 


Ala Lys Gly Leu Ser Asp Val Lys Met Ala Thr Asp Pro Glu Asn Ile 
                165                 170                 175     


Ile Lys Glu Met Pro Val Cys Arg Gln Thr Gly Asn Thr Cys Lys Glu 
            180                 185                 190         


Leu Arg Asp Pro Val Thr Ser Gly Leu Asn Thr Ser Val Val Phe Gly 
        195                 200                 205             


Phe Leu Asn Leu Val Leu Trp Val Gly Asn Leu Trp Phe Val Phe Lys 
    210                 215                 220                 


Glu Thr Gly Trp Ala Ala Pro Phe Leu Arg Ala Pro Pro Gly Ala Pro 
225                 230                 235                 240 


Glu Lys Gln Pro Ala Pro Gly Asp Ala Tyr Gly Asp Ala Gly Tyr Gly 
                245                 250                 255     


Gln Gly Pro Gly Gly Tyr Gly Pro Gln Asp Ser Tyr Gly Pro Gln Gly 
            260                 265                 270         


Gly Tyr Gln Pro Asp Tyr Gly Gln Pro Ala Gly Ser Gly Gly Ser Gly 
        275                 280                 285             


Tyr Gly Pro Gln Gly Asp Tyr Gly Gln Gln Gly Tyr Gly Pro Gln Gly 
    290                 295                 300                 


Ala Pro Thr Ser Phe Ser Asn Gln Met 
305                 310             


<210>  2795
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  2795

Met Phe Pro Glu Pro Pro Thr Pro Gly Pro Pro Ser Pro Asp Thr Pro 
1               5                   10                  15      


Pro Asp Ser Ser Arg Ile Ser His Gly Pro Val Pro Pro Trp Ala Leu 
            20                  25                  30          


Ala Thr Ile Val Leu Val Ser Gly Leu Leu Ile Phe Ser Cys Cys Phe 
        35                  40                  45              


Cys Leu Tyr Arg Lys Ser Cys Arg Arg Arg Thr Gly Lys Lys Ser Gln 
    50                  55                  60                  


Ala Gln Ala Gln Val His Leu Gln Glu Val Lys Gly Leu Gly Gln Ser 
65                  70                  75                  80  


Tyr Ile Asp Lys Val Gln Pro Glu Val Glu Glu Leu Glu Pro Ala Pro 
                85                  90                  95      


Ser Gly Pro Gly Gln Gln Val Ala Asp Lys His Glu Leu Gly Arg Leu 
            100                 105                 110         


Gln Tyr Ser Leu Asp Tyr Asp Phe Gln Ser Gly Gln Leu Leu Val Gly 
        115                 120                 125             


Ile Leu Gln Ala Met Gly Leu Ala Ala Leu Asp Leu Gly Gly Ser Ser 
    130                 135                 140                 


Asp Pro Tyr Val Arg Val Tyr Leu Leu Pro Asp Lys Arg Arg Arg Tyr 
145                 150                 155                 160 


Glu Thr Lys Val His Arg Gln Thr Leu Asn Pro His Phe Gly Glu Thr 
                165                 170                 175     


Phe Ala Phe Lys Val Pro Tyr Val Glu Leu Gly Gly Arg Val Leu Val 
            180                 185                 190         


Met Ala Val Tyr Asp Phe Asp Arg Phe Ser Arg Asn Asp Ala Ile Gly 
        195                 200                 205             


Glu Val Arg Val Pro Met Ser Ser Val Asp Leu Gly Arg Pro Val Gln 
    210                 215                 220                 


Ala Trp Arg Glu Leu Gln Ala Ala Pro Arg Glu Glu Gln Glu Lys Leu 
225                 230                 235                 240 


Gly Asp Ile Cys Phe Ser Leu Arg Tyr Val Pro Thr Ala Gly Lys Leu 
                245                 250                 255     


Thr Val Ile Val Leu Glu Ala Lys Asn Leu Lys Lys Met Asp Val Gly 
            260                 265                 270         


Gly Leu Ser Asp Pro Tyr Val Lys Val His Leu Leu Gln Gly Gly Lys 
        275                 280                 285             


Lys Val Arg Lys Lys Lys Thr Thr Ile Lys Lys Asn Thr Leu Asn Pro 
    290                 295                 300                 


Tyr Tyr Asn Glu Ala Phe Ser Phe Glu Val Pro Cys Asp Gln Val Gln 
305                 310                 315                 320 


Lys Val Gln Val Glu Leu Thr Val Leu Asp Tyr Asp Lys Leu Gly Lys 
                325                 330                 335     


Asn Glu Ala Ile Gly Arg Val Ala Val Gly Ala Ala Ala Gly Gly Ala 
            340                 345                 350         


Gly Leu Arg His Trp Ala Asp Met Leu Ala Asn Pro Arg Arg Pro Ile 
        355                 360                 365             


Ala Gln Trp His Ser Leu Arg Pro Pro Asp Arg Val Arg Leu Leu Pro 
    370                 375                 380                 


Ala Pro 
385     


<210>  2796
<211>  824
<212>  PRT
<213>  Homo sapiens

<400>  2796

Met Arg Gln Ser Leu Leu Phe Leu Thr Ser Val Val Pro Phe Val Leu 
1               5                   10                  15      


Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu 
            20                  25                  30          


Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
        35                  40                  45              


Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr 
    50                  55                  60                  


His Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
65                  70                  75                  80  


Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val 
                85                  90                  95      


Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys Trp Gln 
            100                 105                 110         


Asp Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
        115                 120                 125             


Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly 
    130                 135                 140                 


Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
145                 150                 155                 160 


Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser 
                165                 170                 175     


Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu 
            180                 185                 190         


Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu 
        195                 200                 205             


Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr 
    210                 215                 220                 


Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly 
225                 230                 235                 240 


Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp 
                245                 250                 255     


Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe 
            260                 265                 270         


Lys Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro 
        275                 280                 285             


Gln Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr 
    290                 295                 300                 


Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln 
305                 310                 315                 320 


Phe Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His 
                325                 330                 335     


Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr 
            340                 345                 350         


Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala 
        355                 360                 365             


Tyr Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu 
    370                 375                 380                 


Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp 
385                 390                 395                 400 


Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp 
                405                 410                 415     


Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys 
            420                 425                 430         


Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys 
        435                 440                 445             


Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser 
    450                 455                 460                 


Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn 
465                 470                 475                 480 


Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu 
                485                 490                 495     


Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Glu Gly Val 
            500                 505                 510         


Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu 
        515                 520                 525             


Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly 
    530                 535                 540                 


Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn 
545                 550                 555                 560 


Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly 
                565                 570                 575     


Lys Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala 
            580                 585                 590         


Cys Asn Glu Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser 
        595                 600                 605             


Gly Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu 
    610                 615                 620                 


Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys 
625                 630                 635                 640 


Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile 
                645                 650                 655     


Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile 
            660                 665                 670         


Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser 
        675                 680                 685             


Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser 
    690                 695                 700                 


Leu Ser Leu Phe His Pro Ser Asn Val Glu Met Leu Ser Ser Met Asp 
705                 710                 715                 720 


Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro 
                725                 730                 735     


Gly Arg Leu Gln Pro Ala Pro Val Ile Pro Ser Ala Pro Ala Ala Pro 
            740                 745                 750         


Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp Pro Ser Thr 
        755                 760                 765             


Asp Ser His Met Asp Glu Asp Gly Phe Glu Lys Asp Pro Phe Pro Asn 
    770                 775                 780                 


Ser Ser Thr Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp His Pro Val 
785                 790                 795                 800 


Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg Gln Asn Arg 
                805                 810                 815     


Val Asp Ser Lys Glu Thr Glu Cys 
            820                 


<210>  2797
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  2797

Met Lys Ser Leu Ser Leu Leu Leu Ala Val Ala Leu Gly Leu Ala Thr 
1               5                   10                  15      


Ala Val Ser Ala Gly Pro Ala Val Ile Glu Cys Trp Phe Val Glu Asp 
            20                  25                  30          


Ala Ser Gly Lys Gly Leu Ala Lys Arg Pro Gly Ala Leu Leu Leu Arg 
        35                  40                  45              


Gln Gly Pro Gly Glu Pro Pro Pro Arg Pro Asp Leu Asp Pro Glu Leu 
    50                  55                  60                  


Tyr Leu Ser Val His Asp Pro Ala Gly Ala Leu Gln Ala Ala Phe Arg 
65                  70                  75                  80  


Arg Tyr Pro Arg Gly Ala Pro Ala Pro His Cys Glu Met Ser Arg Phe 
                85                  90                  95      


Val Pro Leu Pro Ala Ser Ala Lys Trp Ala Ser Gly Leu Thr Pro Ala 
            100                 105                 110         


Gln Asn Cys Pro Arg Ala Leu Asp Gly Ala Trp Leu Met Val Ser Ile 
        115                 120                 125             


Ser Ser Pro Val Leu Ser Leu Ser Ser Leu Leu Arg Pro Gln Pro Glu 
    130                 135                 140                 


Pro Gln Gln Glu Pro Val Leu Ile Thr Met Ala Thr Val Val Leu Thr 
145                 150                 155                 160 


Val Leu Thr His Thr Pro Ala Pro Arg Val Arg Leu Gly Gln Asp Ala 
                165                 170                 175     


Leu Leu Asp Leu Ser Phe Ala Tyr Met Pro Pro Thr Ser Glu Ala Ala 
            180                 185                 190         


Ser Ser Leu Ala Pro Gly Pro Pro Pro Phe Gly Leu Glu Trp Arg Arg 
        195                 200                 205             


Gln His Leu Gly Lys Gly His Leu Leu Leu Ala Ala Thr Pro Gly Leu 
    210                 215                 220                 


Asn Gly Gln Met Pro Ala Ala Gln Glu Gly Ala Val Ala Phe Ala Ala 
225                 230                 235                 240 


Trp Asp Asp Asp Glu Pro Trp Gly Pro Trp Thr Gly Asn Gly Thr Phe 
                245                 250                 255     


Trp Leu Pro Thr Val Gln Pro Phe Gln Glu Gly Thr Tyr Leu Ala Thr 
            260                 265                 270         


Ile His Leu Pro Tyr Leu Gln Gly Gln Val Thr Leu Glu Leu Ala Val 
        275                 280                 285             


Tyr Lys Pro Pro Lys Val Ser Leu Met Pro Ala Thr Leu Ala Arg Ala 
    290                 295                 300                 


Ala Pro Gly Glu Ala Pro Pro Glu Leu Leu Cys Leu Val Ser His Phe 
305                 310                 315                 320 


Tyr Pro Ser Gly Gly Leu Glu Val Glu Trp Glu Leu Arg Gly Gly Pro 
                325                 330                 335     


Gly Gly Arg Ser Gln Lys Ala Glu Gly Gln Arg Trp Leu Ser Ala Leu 
            340                 345                 350         


Arg His His Ser Asp Gly Ser Val Ser Leu Ser Gly His Leu Gln Pro 
        355                 360                 365             


Pro Pro Val Thr Thr Glu Gln His Gly Ala Arg Tyr Ala Cys Arg Ile 
    370                 375                 380                 


His His Pro Ser Leu Pro Ala Ser Gly Arg Ser Ala Glu Val Thr Leu 
385                 390                 395                 400 


Glu Val Ala Gly Leu Ser Gly Pro Ser Leu Glu Asp Ser Val Gly Leu 
                405                 410                 415     


Phe Leu Ser Ala Phe Leu Leu Leu Gly Leu Phe Lys Ala Leu Gly Trp 
            420                 425                 430         


Ala Ala Val Tyr Leu Ser Thr Cys Lys Asp Ser Lys Lys Lys Ala Glu 
        435                 440                 445             


<210>  2798
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  2798

Met Asn Ile Phe Asp Arg Lys Ile Asn Phe Asp Ala Leu Leu Lys Phe 
1               5                   10                  15      


Ser His Ile Thr Pro Ser Thr Gln Gln His Leu Lys Lys Val Tyr Ala 
            20                  25                  30          


Ser Phe Ala Leu Cys Met Phe Val Ala Ala Ala Gly Ala Tyr Val His 
        35                  40                  45              


Met Val Thr His Phe Ile Gln Ala Gly Leu Leu Ser Ala Leu Gly Ser 
    50                  55                  60                  


Leu Ile Leu Met Ile Trp Leu Met Ala Thr Pro His Ser His Glu Thr 
65                  70                  75                  80  


Glu Gln Lys Arg Leu Gly Leu Leu Ala Gly Phe Ala Phe Leu Thr Gly 
                85                  90                  95      


Val Gly Leu Gly Pro Ala Leu Glu Phe Cys Ile Ala Val Asn Pro Ser 
            100                 105                 110         


Ile Leu Pro Thr Ala Phe Met Gly Thr Ala Met Ile Phe Thr Cys Phe 
        115                 120                 125             


Thr Leu Ser Ala Leu Tyr Ala Arg Arg Arg Ser Tyr Leu Phe Leu Gly 
    130                 135                 140                 


Gly Ile Leu Met Ser Ala Leu Ser Leu Leu Leu Leu Ser Ser Leu Gly 
145                 150                 155                 160 


Asn Val Phe Phe Gly Ser Ile Trp Leu Phe Gln Ala Asn Leu Tyr Val 
                165                 170                 175     


Gly Leu Val Val Met Cys Gly Phe Val Leu Phe Asp Thr Gln Leu Ile 
            180                 185                 190         


Ile Glu Lys Ala Glu His Gly Asp Gln Asp Tyr Ile Trp His Cys Ile 
        195                 200                 205             


Asp Leu Phe Leu Asp Phe Ile Thr Val Phe Arg Lys Leu Met Met Ile 
    210                 215                 220                 


Leu Ala Met Asn Glu Lys Asp Lys Lys Lys Glu Lys Lys 
225                 230                 235         


<210>  2799
<211>  801
<212>  PRT
<213>  Homo sapiens

<400>  2799

Met Glu Arg Leu Trp Gly Leu Phe Gln Arg Ala Gln Gln Leu Ser Pro 
1               5                   10                  15      


Arg Ser Ser Gln Thr Val Tyr Gln Arg Val Glu Gly Pro Arg Lys Gly 
            20                  25                  30          


His Leu Glu Glu Glu Glu Glu Asp Gly Glu Glu Gly Ala Glu Thr Leu 
        35                  40                  45              


Ala His Phe Cys Pro Met Glu Leu Arg Gly Pro Glu Pro Leu Gly Ser 
    50                  55                  60                  


Arg Pro Arg Gln Pro Asn Leu Ile Pro Trp Ala Ala Ala Gly Arg Arg 
65                  70                  75                  80  


Ala Ala Pro Tyr Leu Val Leu Thr Ala Leu Leu Ile Phe Thr Gly Ala 
                85                  90                  95      


Phe Leu Leu Gly Tyr Val Ala Phe Arg Gly Ser Cys Gln Ala Cys Gly 
            100                 105                 110         


Asp Ser Val Leu Val Val Ser Glu Asp Val Asn Tyr Glu Pro Asp Leu 
        115                 120                 125             


Asp Phe His Gln Gly Arg Leu Tyr Trp Ser Asp Leu Gln Ala Met Phe 
    130                 135                 140                 


Leu Gln Phe Leu Gly Glu Gly Arg Leu Glu Asp Thr Ile Arg Gln Thr 
145                 150                 155                 160 


Ser Leu Arg Glu Arg Val Ala Gly Ser Ala Gly Met Ala Ala Leu Thr 
                165                 170                 175     


Gln Asp Ile Arg Ala Ala Leu Ser Arg Gln Lys Leu Asp His Val Trp 
            180                 185                 190         


Thr Asp Thr His Tyr Val Gly Leu Gln Phe Pro Asp Pro Ala His Pro 
        195                 200                 205             


Asn Thr Leu His Trp Val Asp Glu Ala Gly Lys Val Gly Glu Gln Leu 
    210                 215                 220                 


Pro Leu Glu Asp Pro Asp Val Tyr Cys Pro Tyr Ser Ala Ile Gly Asn 
225                 230                 235                 240 


Val Thr Gly Glu Leu Val Tyr Ala His Tyr Gly Arg Pro Glu Asp Leu 
                245                 250                 255     


Gln Asp Leu Arg Ala Arg Gly Val Asp Pro Val Gly Arg Leu Leu Leu 
            260                 265                 270         


Val Arg Val Gly Val Ile Ser Phe Ala Gln Lys Val Thr Asn Ala Gln 
        275                 280                 285             


Asp Phe Gly Ala Gln Gly Val Leu Ile Tyr Pro Glu Pro Ala Asp Phe 
    290                 295                 300                 


Ser Gln Asp Pro Pro Lys Pro Ser Leu Ser Ser Gln Gln Ala Val Tyr 
305                 310                 315                 320 


Gly His Val His Leu Gly Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro 
                325                 330                 335     


Ser Phe Asn Gln Thr Gln Phe Pro Pro Val Ala Ser Ser Gly Leu Pro 
            340                 345                 350         


Ser Ile Pro Ala Gln Pro Ile Ser Ala Asp Ile Ala Ser Arg Leu Leu 
        355                 360                 365             


Arg Lys Leu Lys Gly Pro Val Ala Pro Gln Glu Trp Gln Gly Ser Leu 
    370                 375                 380                 


Leu Gly Ser Pro Tyr His Leu Gly Pro Gly Pro Arg Leu Arg Leu Val 
385                 390                 395                 400 


Val Asn Asn His Arg Thr Ser Thr Pro Ile Asn Asn Ile Phe Gly Cys 
                405                 410                 415     


Ile Glu Gly Arg Ser Glu Pro Asp His Tyr Val Val Ile Gly Ala Gln 
            420                 425                 430         


Arg Asp Ala Trp Gly Pro Gly Ala Ala Lys Ser Ala Val Gly Thr Ala 
        435                 440                 445             


Ile Leu Leu Glu Leu Val Arg Thr Phe Ser Ser Met Val Ser Asn Gly 
    450                 455                 460                 


Phe Arg Pro Arg Arg Ser Leu Leu Phe Ile Ser Trp Asp Gly Gly Asp 
465                 470                 475                 480 


Phe Gly Ser Val Gly Ser Thr Glu Trp Leu Glu Gly Tyr Leu Ser Val 
                485                 490                 495     


Leu His Leu Lys Ala Val Val Tyr Val Ser Leu Asp Asn Ala Val Leu 
            500                 505                 510         


Gly Asp Asp Lys Phe His Ala Lys Thr Ser Pro Leu Leu Thr Ser Leu 
        515                 520                 525             


Ile Glu Ser Val Leu Lys Gln Val Asp Ser Pro Asn His Ser Gly Gln 
    530                 535                 540                 


Thr Leu Tyr Glu Gln Val Val Phe Thr Asn Pro Ser Trp Asp Ala Glu 
545                 550                 555                 560 


Val Ile Arg Pro Leu Pro Met Asp Ser Ser Ala Tyr Ser Phe Thr Ala 
                565                 570                 575     


Phe Val Gly Val Pro Ala Val Glu Phe Ser Phe Met Glu Asp Asp Gln 
            580                 585                 590         


Ala Tyr Pro Phe Leu His Thr Lys Glu Asp Thr Tyr Glu Asn Leu His 
        595                 600                 605             


Lys Val Leu Gln Gly Arg Leu Pro Ala Val Ala Gln Ala Val Ala Gln 
    610                 615                 620                 


Leu Ala Gly Gln Leu Leu Ile Arg Leu Ser His Asp Arg Leu Leu Pro 
625                 630                 635                 640 


Leu Asp Phe Gly Arg Tyr Gly Asp Val Val Leu Arg His Ile Gly Asn 
                645                 650                 655     


Leu Asn Glu Phe Ser Gly Asp Leu Lys Ala Arg Gly Leu Thr Leu Gln 
            660                 665                 670         


Trp Val Tyr Ser Ala Arg Gly Asp Tyr Ile Arg Ala Ala Glu Lys Leu 
        675                 680                 685             


Arg Gln Glu Ile Tyr Ser Ser Glu Glu Arg Asp Glu Arg Leu Thr Arg 
    690                 695                 700                 


Met Tyr Asn Val Arg Ile Met Arg Val Glu Phe Tyr Phe Leu Ser Gln 
705                 710                 715                 720 


Tyr Val Ser Pro Ala Asp Ser Pro Phe Arg His Ile Phe Met Gly Arg 
                725                 730                 735     


Gly Asp His Thr Leu Gly Ala Leu Leu Asp His Leu Arg Leu Leu Arg 
            740                 745                 750         


Ser Asn Ser Ser Gly Thr Pro Gly Ala Thr Ser Ser Thr Gly Phe Gln 
        755                 760                 765             


Glu Ser Arg Phe Arg Arg Gln Leu Ala Leu Leu Thr Trp Thr Leu Gln 
    770                 775                 780                 


Gly Ala Ala Asn Ala Leu Ser Gly Asp Val Trp Asn Ile Asp Asn Asn 
785                 790                 795                 800 


Phe 
    


<210>  2800
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  2800

Met Val Pro Ser Ala Gly Gln Leu Ala Leu Phe Ala Leu Gly Ile Val 
1               5                   10                  15      


Leu Ala Ala Cys Gln Ala Leu Glu Asn Ser Thr Ser Pro Leu Ser Ala 
            20                  25                  30          


Asp Pro Pro Val Ala Ala Ala Val Val Ser His Phe Asn Asp Cys Pro 
        35                  40                  45              


Asp Ser His Thr Gln Phe Cys Phe His Gly Thr Cys Arg Phe Leu Val 
    50                  55                  60                  


Gln Glu Asp Lys Pro Ala Cys Val Cys His Ser Gly Tyr Val Gly Ala 
65                  70                  75                  80  


Arg Cys Glu His Ala Asp Leu Leu Ala Val Val Ala Ala Ser Gln Lys 
                85                  90                  95      


Lys Gln Ala Ile Thr Ala Leu Val Val Val Ser Ile Val Ala Leu Ala 
            100                 105                 110         


Val Leu Ile Ile Thr Cys Val Leu Ile His Cys Cys Gln Val Arg Lys 
        115                 120                 125             


His Cys Glu Trp Cys Arg Ala Leu Ile Cys Arg His Glu Lys Pro Ser 
    130                 135                 140                 


Ala Leu Leu Lys Gly Arg Thr Ala Cys Cys His Ser Glu Thr Val Val 
145                 150                 155                 160 


<210>  2801
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  2801

Met Lys Met His Leu Gln Arg Ala Leu Val Val Leu Ala Leu Leu Asn 
1               5                   10                  15      


Phe Ala Thr Val Ser Leu Ser Leu Ser Thr Cys Thr Thr Leu Asp Phe 
            20                  25                  30          


Gly His Ile Lys Lys Lys Arg Val Glu Ala Ile Arg Gly Gln Ile Leu 
        35                  40                  45              


Ser Lys Leu Arg Leu Thr Ser Pro Pro Glu Pro Thr Val Met Thr His 
    50                  55                  60                  


Val Pro Tyr Gln Val Leu Ala Leu Tyr Asn Ser Thr Arg Glu Leu Leu 
65                  70                  75                  80  


Glu Glu Met His Gly Glu Arg Glu Glu Gly Cys Thr Gln Glu Asn Thr 
                85                  90                  95      


Glu Ser Glu Tyr Tyr Ala Lys Glu Ile His Lys Phe Asp Met Ile Gln 
            100                 105                 110         


Gly Leu Ala Glu His Asn Glu Leu Ala Val Cys Pro Lys Gly Ile Thr 
        115                 120                 125             


Ser Lys Val Phe Arg Phe Asn Val Ser Ser Val Glu Lys Asn Arg Thr 
    130                 135                 140                 


Asn Leu Phe Arg Ala Glu Phe Arg Val Leu Arg Val Pro Asn Pro Ser 
145                 150                 155                 160 


Ser Lys Arg Asn Glu Gln Arg Ile Glu Leu Phe Gln Ile Leu Arg Pro 
                165                 170                 175     


Asp Glu His Ile Ala Lys Gln Arg Tyr Ile Gly Gly Lys Asn Leu Pro 
            180                 185                 190         


Thr Arg Gly Thr Ala Glu Trp Leu Ser Phe Asp Val Thr Asp Thr Val 
        195                 200                 205             


Arg Glu Trp Leu Leu Arg Arg Glu Ser Asn Leu Gly Leu Glu Ile Ser 
    210                 215                 220                 


Ile His Cys Pro Cys His Thr Phe Gln Pro Asn Gly Asp Ile Leu Glu 
225                 230                 235                 240 


Asn Ile His Glu Val Met Glu Ile Lys Phe Lys Gly Val Asp Asn Glu 
                245                 250                 255     


Asp Asp His Gly Arg Gly Asp Leu Gly Arg Leu Lys Lys Gln Lys Asp 
            260                 265                 270         


His His Asn Pro His Leu Ile Leu Met Met Ile Pro Pro His Arg Leu 
        275                 280                 285             


Asp Asn Pro Gly Gln Gly Gly Gln Arg Lys Lys Arg Ala Leu Asp Thr 
    290                 295                 300                 


Asn Tyr Cys Phe Arg Asn Leu Glu Glu Asn Cys Cys Val Arg Pro Leu 
305                 310                 315                 320 


Tyr Ile Asp Phe Arg Gln Asp Leu Gly Trp Lys Trp Val His Glu Pro 
                325                 330                 335     


Lys Gly Tyr Tyr Ala Asn Phe Cys Ser Gly Pro Cys Pro Tyr Leu Arg 
            340                 345                 350         


Ser Ala Asp Thr Thr His Ser Thr Val Leu Gly Leu Tyr Asn Thr Leu 
        355                 360                 365             


Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Pro Gln Asp Leu Glu 
    370                 375                 380                 


Pro Leu Thr Ile Leu Tyr Tyr Val Gly Arg Thr Pro Lys Val Glu Gln 
385                 390                 395                 400 


Leu Ser Asn Met Val Val Lys Ser Cys Lys Cys Ser 
                405                 410         


<210>  2802
<211>  567
<212>  PRT
<213>  Homo sapiens

<400>  2802

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Thr Trp Glu Thr Gly Lys Thr Arg Lys 
        195                 200                 205             


Leu Met Glu Phe Ser Glu His Cys Ala Ile Ile Leu Glu Asp Asp Arg 
    210                 215                 220                 


Ser Asp Ile Ser Ser Thr Cys Ala Asn Asn Ile Asn His Asn Thr Glu 
225                 230                 235                 240 


Leu Leu Pro Ile Glu Leu Asp Thr Leu Val Gly Lys Gly Arg Phe Ala 
                245                 250                 255     


Glu Val Tyr Lys Ala Lys Leu Lys Gln Asn Thr Ser Glu Gln Phe Glu 
            260                 265                 270         


Thr Val Ala Val Lys Ile Phe Pro Tyr Glu Glu Tyr Ala Ser Trp Lys 
        275                 280                 285             


Thr Glu Lys Asp Ile Phe Ser Asp Ile Asn Leu Lys His Glu Asn Ile 
    290                 295                 300                 


Leu Gln Phe Leu Thr Ala Glu Glu Arg Lys Thr Glu Leu Gly Lys Gln 
305                 310                 315                 320 


Tyr Trp Leu Ile Thr Ala Phe His Ala Lys Gly Asn Leu Gln Glu Tyr 
                325                 330                 335     


Leu Thr Arg His Val Ile Ser Trp Glu Asp Leu Arg Lys Leu Gly Ser 
            340                 345                 350         


Ser Leu Ala Arg Gly Ile Ala His Leu His Ser Asp His Thr Pro Cys 
        355                 360                 365             


Gly Arg Pro Lys Met Pro Ile Val His Arg Asp Leu Lys Ser Ser Asn 
    370                 375                 380                 


Ile Leu Val Lys Asn Asp Leu Thr Cys Cys Leu Cys Asp Phe Gly Leu 
385                 390                 395                 400 


Ser Leu Arg Leu Asp Pro Thr Leu Ser Val Asp Asp Leu Ala Asn Ser 
                405                 410                 415     


Gly Gln Val Gly Thr Ala Arg Tyr Met Ala Pro Glu Val Leu Glu Ser 
            420                 425                 430         


Arg Met Asn Leu Glu Asn Val Glu Ser Phe Lys Gln Thr Asp Val Tyr 
        435                 440                 445             


Ser Met Ala Leu Val Leu Trp Glu Met Thr Ser Arg Cys Asn Ala Val 
    450                 455                 460                 


Gly Glu Val Lys Asp Tyr Glu Pro Pro Phe Gly Ser Lys Val Arg Glu 
465                 470                 475                 480 


His Pro Cys Val Glu Ser Met Lys Asp Asn Val Leu Arg Asp Arg Gly 
                485                 490                 495     


Arg Pro Glu Ile Pro Ser Phe Trp Leu Asn His Gln Gly Ile Gln Met 
            500                 505                 510         


Val Cys Glu Thr Leu Thr Glu Cys Trp Asp His Asp Pro Glu Ala Arg 
        515                 520                 525             


Leu Thr Ala Gln Cys Val Ala Glu Arg Phe Ser Glu Leu Glu His Leu 
    530                 535                 540                 


Asp Arg Leu Ser Gly Arg Ser Cys Ser Glu Glu Lys Ile Pro Glu Asp 
545                 550                 555                 560 


Gly Ser Leu Asn Thr Thr Lys 
                565         


<210>  2803
<211>  851
<212>  PRT
<213>  Homo sapiens

<400>  2803

Met Thr Ser His Tyr Val Ile Ala Ile Phe Ala Leu Met Ser Ser Cys 
1               5                   10                  15      


Leu Ala Thr Ala Gly Pro Glu Pro Gly Ala Leu Cys Glu Leu Ser Pro 
            20                  25                  30          


Val Ser Ala Ser His Pro Val Gln Ala Leu Met Glu Ser Phe Thr Val 
        35                  40                  45              


Leu Ser Gly Cys Ala Ser Arg Gly Thr Thr Gly Leu Pro Gln Glu Val 
    50                  55                  60                  


His Val Leu Asn Leu Arg Thr Ala Gly Gln Gly Pro Gly Gln Leu Gln 
65                  70                  75                  80  


Arg Glu Val Thr Leu His Leu Asn Pro Ile Ser Ser Val His Ile His 
                85                  90                  95      


His Lys Ser Val Val Phe Leu Leu Asn Ser Pro His Pro Leu Val Trp 
            100                 105                 110         


His Leu Lys Thr Glu Arg Leu Ala Thr Gly Val Ser Arg Leu Phe Leu 
        115                 120                 125             


Val Ser Glu Gly Ser Val Val Gln Phe Ser Ser Ala Asn Phe Ser Leu 
    130                 135                 140                 


Thr Ala Glu Thr Glu Glu Arg Asn Phe Pro His Gly Asn Glu His Leu 
145                 150                 155                 160 


Leu Asn Trp Ala Arg Lys Glu Tyr Gly Ala Val Thr Ser Phe Thr Glu 
                165                 170                 175     


Leu Lys Ile Ala Arg Asn Ile Tyr Ile Lys Val Gly Glu Asp Gln Val 
            180                 185                 190         


Phe Pro Pro Lys Cys Asn Ile Gly Lys Asn Phe Leu Ser Leu Asn Tyr 
        195                 200                 205             


Leu Ala Glu Tyr Leu Gln Pro Lys Ala Ala Glu Gly Cys Val Met Ser 
    210                 215                 220                 


Ser Gln Pro Gln Asn Glu Glu Val His Ile Ile Glu Leu Ile Thr Pro 
225                 230                 235                 240 


Asn Ser Asn Pro Tyr Ser Ala Phe Gln Val Asp Ile Thr Ile Asp Ile 
                245                 250                 255     


Arg Pro Ser Gln Glu Asp Leu Glu Val Val Lys Asn Leu Ile Leu Ile 
            260                 265                 270         


Leu Lys Cys Lys Lys Ser Val Asn Trp Val Ile Lys Ser Phe Asp Val 
        275                 280                 285             


Lys Gly Ser Leu Lys Ile Ile Ala Pro Asn Ser Ile Gly Phe Gly Lys 
    290                 295                 300                 


Glu Ser Glu Arg Ser Met Thr Met Thr Lys Ser Ile Arg Asp Asp Ile 
305                 310                 315                 320 


Pro Ser Thr Gln Gly Asn Leu Val Lys Trp Ala Leu Asp Asn Gly Tyr 
                325                 330                 335     


Ser Pro Ile Thr Ser Tyr Thr Met Ala Pro Val Ala Asn Arg Phe His 
            340                 345                 350         


Leu Arg Leu Glu Asn Asn Ala Glu Glu Met Gly Asp Glu Glu Val His 
        355                 360                 365             


Thr Ile Pro Pro Glu Leu Arg Ile Leu Leu Asp Pro Gly Ala Leu Pro 
    370                 375                 380                 


Ala Leu Gln Asn Pro Pro Ile Arg Gly Gly Glu Gly Gln Asn Gly Gly 
385                 390                 395                 400 


Leu Pro Phe Pro Phe Pro Asp Ile Ser Arg Arg Val Trp Asn Glu Glu 
                405                 410                 415     


Gly Glu Asp Gly Leu Pro Arg Pro Lys Asp Pro Val Ile Pro Ser Ile 
            420                 425                 430         


Gln Leu Phe Pro Gly Leu Arg Glu Pro Glu Glu Val Gln Gly Ser Val 
        435                 440                 445             


Asp Ile Ala Leu Ser Val Lys Cys Asp Asn Glu Lys Met Ile Val Ala 
    450                 455                 460                 


Val Glu Lys Asp Ser Phe Gln Ala Ser Gly Tyr Ser Gly Met Asp Val 
465                 470                 475                 480 


Thr Leu Leu Asp Pro Thr Cys Lys Ala Lys Met Asn Gly Thr His Phe 
                485                 490                 495     


Val Leu Glu Ser Pro Leu Asn Gly Cys Gly Thr Arg Pro Arg Trp Ser 
            500                 505                 510         


Ala Leu Asp Gly Val Val Tyr Tyr Asn Ser Ile Val Ile Gln Val Pro 
        515                 520                 525             


Ala Leu Gly Asp Ser Ser Gly Trp Pro Asp Gly Tyr Glu Asp Leu Glu 
    530                 535                 540                 


Ser Gly Asp Asn Gly Phe Pro Gly Asp Met Asp Glu Gly Asp Ala Ser 
545                 550                 555                 560 


Leu Phe Thr Arg Pro Glu Ile Val Val Phe Asn Cys Ser Leu Gln Gln 
                565                 570                 575     


Val Arg Asn Pro Ser Ser Phe Gln Glu Gln Pro His Gly Asn Ile Thr 
            580                 585                 590         


Phe Asn Met Glu Leu Tyr Asn Thr Asp Leu Phe Leu Val Pro Ser Gln 
        595                 600                 605             


Gly Val Phe Ser Val Pro Glu Asn Gly His Val Tyr Val Glu Val Ser 
    610                 615                 620                 


Val Thr Lys Ala Glu Gln Glu Leu Gly Phe Ala Ile Gln Thr Cys Phe 
625                 630                 635                 640 


Ile Ser Pro Tyr Ser Asn Pro Asp Arg Met Ser His Tyr Thr Ile Ile 
                645                 650                 655     


Glu Asn Ile Cys Pro Lys Asp Glu Ser Val Lys Phe Tyr Ser Pro Lys 
            660                 665                 670         


Arg Val His Phe Pro Ile Pro Gln Ala Asp Met Asp Lys Lys Arg Phe 
        675                 680                 685             


Ser Phe Val Phe Lys Pro Val Phe Asn Thr Ser Leu Leu Phe Leu Gln 
    690                 695                 700                 


Cys Glu Leu Thr Leu Cys Thr Lys Met Glu Lys His Pro Gln Lys Leu 
705                 710                 715                 720 


Pro Lys Cys Val Pro Pro Asp Glu Ala Cys Thr Ser Leu Asp Ala Ser 
                725                 730                 735     


Ile Ile Trp Ala Met Met Gln Asn Lys Lys Thr Phe Thr Lys Pro Leu 
            740                 745                 750         


Ala Val Ile His His Glu Ala Glu Ser Lys Glu Lys Gly Pro Ser Met 
        755                 760                 765             


Lys Glu Pro Asn Pro Ile Ser Pro Pro Ile Phe His Gly Leu Asp Thr 
    770                 775                 780                 


Leu Thr Val Met Gly Ile Ala Phe Ala Ala Phe Val Ile Gly Ala Leu 
785                 790                 795                 800 


Leu Thr Gly Ala Leu Trp Tyr Ile Tyr Ser His Thr Gly Glu Thr Ala 
                805                 810                 815     


Gly Arg Gln Gln Val Pro Thr Ser Pro Pro Ala Ser Glu Asn Ser Ser 
            820                 825                 830         


Ala Ala His Ser Ile Gly Ser Thr Gln Ser Thr Pro Cys Ser Ser Ser 
        835                 840                 845             


Ser Thr Ala 
    850     


<210>  2804
<211>  924
<212>  PRT
<213>  Homo sapiens

<400>  2804

Met Pro Gly Pro Ser Pro Gly Leu Arg Arg Ala Leu Leu Gly Leu Trp 
1               5                   10                  15      


Ala Ala Leu Gly Leu Gly Leu Phe Gly Leu Ser Ala Val Ser Gln Glu 
            20                  25                  30          


Pro Phe Trp Ala Asp Leu Gln Pro Arg Val Ala Phe Val Glu Arg Gly 
        35                  40                  45              


Gly Ser Leu Trp Leu Asn Cys Ser Thr Asn Cys Pro Arg Pro Glu Arg 
    50                  55                  60                  


Gly Gly Leu Glu Thr Ser Leu Arg Arg Asn Gly Thr Gln Arg Gly Leu 
65                  70                  75                  80  


Arg Trp Leu Ala Arg Gln Leu Val Asp Ile Arg Glu Pro Glu Thr Gln 
                85                  90                  95      


Pro Val Cys Phe Phe Arg Cys Ala Arg Arg Thr Leu Gln Ala Arg Gly 
            100                 105                 110         


Leu Ile Arg Thr Phe Gln Arg Pro Asp Arg Val Glu Leu Met Pro Leu 
        115                 120                 125             


Pro Pro Trp Gln Pro Val Gly Glu Asn Phe Thr Leu Ser Cys Arg Val 
    130                 135                 140                 


Pro Gly Ala Gly Pro Arg Ala Ser Leu Thr Leu Thr Leu Leu Arg Gly 
145                 150                 155                 160 


Ala Gln Glu Leu Ile Arg Arg Ser Phe Ala Gly Glu Pro Pro Arg Ala 
                165                 170                 175     


Arg Gly Ala Val Leu Thr Ala Thr Val Leu Ala Arg Arg Glu Asp His 
            180                 185                 190         


Gly Ala Asn Phe Ser Cys Arg Ala Glu Leu Asp Leu Arg Pro His Gly 
        195                 200                 205             


Leu Gly Leu Phe Glu Asn Ser Ser Ala Pro Arg Glu Leu Arg Thr Phe 
    210                 215                 220                 


Ser Leu Ser Pro Asp Ala Pro Arg Leu Ala Ala Pro Arg Leu Leu Glu 
225                 230                 235                 240 


Val Gly Ser Glu Arg Pro Val Ser Cys Thr Leu Asp Gly Leu Phe Pro 
                245                 250                 255     


Ala Ser Glu Ala Arg Val Tyr Leu Ala Leu Gly Asp Gln Asn Leu Ser 
            260                 265                 270         


Pro Asp Val Thr Leu Glu Gly Asp Ala Phe Val Ala Thr Ala Thr Ala 
        275                 280                 285             


Thr Ala Ser Ala Glu Gln Glu Gly Ala Arg Gln Leu Val Cys Asn Val 
    290                 295                 300                 


Thr Leu Gly Gly Glu Asn Arg Glu Thr Arg Glu Asn Val Thr Ile Tyr 
305                 310                 315                 320 


Ser Phe Pro Ala Pro Leu Leu Thr Leu Ser Glu Pro Ser Val Ser Glu 
                325                 330                 335     


Gly Gln Met Val Thr Val Thr Cys Ala Ala Gly Ala Gln Ala Leu Val 
            340                 345                 350         


Thr Leu Glu Gly Val Pro Ala Ala Val Pro Gly Gln Pro Ala Gln Leu 
        355                 360                 365             


Gln Leu Asn Ala Thr Glu Asn Asp Asp Arg Arg Ser Phe Phe Cys Asp 
    370                 375                 380                 


Ala Thr Leu Asp Val Asp Gly Glu Thr Leu Ile Lys Asn Arg Ser Ala 
385                 390                 395                 400 


Glu Leu Arg Val Leu Tyr Ala Pro Arg Leu Asp Asp Ser Asp Cys Pro 
                405                 410                 415     


Arg Ser Trp Thr Trp Pro Glu Gly Pro Glu Gln Thr Leu Arg Cys Glu 
            420                 425                 430         


Ala Arg Gly Asn Pro Glu Pro Ser Val His Cys Ala Arg Ser Asp Gly 
        435                 440                 445             


Gly Ala Val Leu Ala Leu Gly Leu Leu Gly Pro Val Thr Arg Ala Leu 
    450                 455                 460                 


Ser Gly Thr Tyr Arg Cys Lys Ala Ala Asn Asp Gln Gly Glu Ala Val 
465                 470                 475                 480 


Lys Asp Val Thr Leu Thr Val Glu Tyr Ala Pro Ala Leu Asp Ser Val 
                485                 490                 495     


Gly Cys Pro Glu Arg Ile Thr Trp Leu Glu Gly Thr Glu Ala Ser Leu 
            500                 505                 510         


Ser Cys Val Ala His Gly Val Pro Pro Pro Asp Val Ile Cys Val Arg 
        515                 520                 525             


Ser Gly Glu Leu Gly Ala Val Ile Glu Gly Leu Leu Arg Val Ala Arg 
    530                 535                 540                 


Glu His Ala Gly Thr Tyr Arg Cys Glu Ala Thr Asn Pro Arg Gly Ser 
545                 550                 555                 560 


Ala Ala Lys Asn Val Ala Val Thr Val Glu Tyr Gly Pro Arg Phe Glu 
                565                 570                 575     


Glu Pro Ser Cys Pro Ser Asn Trp Thr Trp Val Glu Gly Ser Gly Arg 
            580                 585                 590         


Leu Phe Ser Cys Glu Val Asp Gly Lys Pro Gln Pro Ser Val Lys Cys 
        595                 600                 605             


Val Gly Ser Gly Gly Ala Thr Glu Gly Val Leu Leu Pro Leu Ala Pro 
    610                 615                 620                 


Pro Asp Pro Ser Pro Arg Ala Pro Arg Ile Pro Arg Val Leu Ala Pro 
625                 630                 635                 640 


Gly Ile Tyr Val Cys Asn Ala Thr Asn Arg His Gly Ser Val Ala Lys 
                645                 650                 655     


Thr Val Val Val Ser Ala Glu Ser Pro Pro Glu Met Asp Glu Ser Thr 
            660                 665                 670         


Cys Pro Ser His Gln Thr Trp Leu Glu Gly Ala Glu Ala Ser Ala Leu 
        675                 680                 685             


Ala Cys Ala Ala Arg Gly Arg Pro Ser Pro Gly Val Arg Cys Ser Arg 
    690                 695                 700                 


Glu Gly Ile Pro Trp Pro Glu Gln Gln Arg Val Ser Arg Glu Asp Ala 
705                 710                 715                 720 


Gly Thr Tyr His Cys Val Ala Thr Asn Ala His Gly Thr Asp Ser Arg 
                725                 730                 735     


Thr Val Thr Val Gly Val Glu Tyr Arg Pro Val Val Ala Glu Leu Ala 
            740                 745                 750         


Ala Ser Pro Pro Gly Gly Val Arg Pro Gly Gly Asn Phe Thr Leu Thr 
        755                 760                 765             


Cys Arg Ala Glu Ala Trp Pro Pro Ala Gln Ile Ser Trp Arg Ala Pro 
    770                 775                 780                 


Pro Gly Ala Leu Asn Ile Gly Leu Ser Ser Asn Asn Ser Thr Leu Ser 
785                 790                 795                 800 


Val Ala Gly Ala Met Gly Ser His Gly Gly Glu Tyr Glu Cys Ala Ala 
                805                 810                 815     


Thr Asn Ala His Gly Arg His Ala Arg Arg Ile Thr Val Arg Val Ala 
            820                 825                 830         


Gly Pro Trp Leu Trp Val Ala Val Gly Gly Ala Ala Gly Gly Ala Ala 
        835                 840                 845             


Leu Leu Ala Ala Gly Ala Gly Leu Ala Phe Tyr Val Gln Ser Thr Ala 
    850                 855                 860                 


Cys Lys Lys Gly Glu Tyr Asn Val Gln Glu Ala Glu Ser Ser Gly Glu 
865                 870                 875                 880 


Ala Val Cys Leu Asn Gly Ala Gly Gly Gly Ala Gly Gly Ala Ala Gly 
                885                 890                 895     


Ala Glu Gly Gly Pro Glu Ala Ala Gly Gly Ala Ala Glu Ser Pro Ala 
            900                 905                 910         


Glu Gly Glu Val Phe Ala Ile Gln Leu Thr Ser Ala 
        915                 920                 


<210>  2805
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  2805

Met Ala Glu Arg Arg Arg His Lys Lys Arg Ile Gln Glu Val Gly Glu 
1               5                   10                  15      


Pro Ser Lys Glu Glu Lys Ala Val Ala Lys Tyr Leu Arg Phe Asn Cys 
            20                  25                  30          


Pro Thr Lys Ser Thr Asn Met Met Gly His Arg Val Asp Tyr Phe Ile 
        35                  40                  45              


Ala Ser Lys Ala Val Asp Cys Leu Leu Asp Ser Lys Trp Ala Lys Ala 
    50                  55                  60                  


Lys Lys Gly Glu Glu Ala Leu Phe Thr Thr Arg Glu Ser Val Val Asp 
65                  70                  75                  80  


Tyr Cys Asn Arg Leu Leu Lys Lys Gln Phe Phe His Arg Ala Leu Lys 
                85                  90                  95      


Val Met Lys Met Lys Tyr Asp Lys Asp Ile Lys Lys Glu Lys Asp Lys 
            100                 105                 110         


Gly Lys Ala Glu Ser Gly Lys Glu Glu Asp Lys Lys Ser Lys Lys Glu 
        115                 120                 125             


Asn Ile Lys Asp Glu Lys Thr Lys Lys Glu Lys Glu Lys Lys Lys Asp 
    130                 135                 140                 


Gly Glu Lys Glu Glu Ser Lys Lys Glu Glu Thr Pro Gly Thr Pro Lys 
145                 150                 155                 160 


Lys Lys Glu Thr Lys Lys Lys Phe Lys Leu Glu Pro His Asp Asp Gln 
                165                 170                 175     


Val Phe Leu Asp Gly Asn Glu Val Tyr Val Trp Ile Tyr Asp Pro Val 
            180                 185                 190         


His Phe Lys Thr Phe Val Met Gly Leu Ile Leu Val Ile Ala Val Ile 
        195                 200                 205             


Ala Ala Thr Leu Phe Pro Leu Trp Pro Ala Glu Met Arg Val Gly Val 
    210                 215                 220                 


Tyr Tyr Leu Ser Val Gly Ala Gly Cys Phe Val Ala Ser Ile Leu Leu 
225                 230                 235                 240 


Leu Ala Val Ala Arg Cys Ile Leu Phe Leu Ile Ile Trp Leu Ile Thr 
                245                 250                 255     


Gly Gly Arg His His Phe Trp Phe Leu Pro Asn Leu Thr Ala Asp Val 
            260                 265                 270         


Gly Phe Ile Asp Ser Phe Arg Pro Leu Tyr Thr His Glu Tyr Lys Gly 
        275                 280                 285             


Pro Lys Ala Asp Leu Lys Lys Asp Glu Lys Ser Glu Thr Lys Lys Gln 
    290                 295                 300                 


Gln Lys Ser Asp Ser Glu Glu Lys Ser Asp Ser Glu Lys Lys Glu Asp 
305                 310                 315                 320 


Glu Glu Gly Lys Val Gly Pro Gly Asn His Gly Thr Glu Gly Ser Gly 
                325                 330                 335     


Gly Glu Arg His Ser Asp Thr Asp Ser Asp Arg Arg Glu Asp Asp Arg 
            340                 345                 350         


Ser Gln His Ser Ser Gly Asn Gly Asn Asp Phe Glu Met Ile Thr Lys 
        355                 360                 365             


Glu Glu Leu Glu Gln Gln Thr Asp Gly Asp Cys Glu Glu Asp Glu Glu 
    370                 375                 380                 


Glu Glu Asn Asp Gly Glu Thr Pro Lys Ser Ser His Glu Lys Ser 
385                 390                 395                 


<210>  2806
<211>  786
<212>  PRT
<213>  Homo sapiens

<400>  2806

Met Thr Ser Ile Phe His Phe Ala Ile Ile Phe Met Leu Ile Leu Gln 
1               5                   10                  15      


Ile Arg Ile Gln Leu Ser Glu Glu Ser Glu Phe Leu Val Asp Arg Ser 
            20                  25                  30          


Lys Asn Gly Leu Ile His Val Pro Lys Asp Leu Ser Gln Lys Thr Thr 
        35                  40                  45              


Ile Leu Asn Ile Ser Gln Asn Tyr Ile Ser Glu Leu Trp Thr Ser Asp 
    50                  55                  60                  


Ile Leu Ser Leu Ser Lys Leu Arg Ile Leu Ile Ile Ser His Asn Arg 
65                  70                  75                  80  


Ile Gln Tyr Leu Asp Ile Ser Val Phe Lys Phe Asn Gln Glu Leu Glu 
                85                  90                  95      


Tyr Leu Asp Leu Ser His Asn Lys Leu Val Lys Ile Ser Cys His Pro 
            100                 105                 110         


Thr Val Asn Leu Lys His Leu Asp Leu Ser Phe Asn Ala Phe Asp Ala 
        115                 120                 125             


Leu Pro Ile Cys Lys Glu Phe Gly Asn Met Ser Gln Leu Lys Phe Leu 
    130                 135                 140                 


Gly Leu Ser Thr Thr His Leu Glu Lys Ser Ser Val Leu Pro Ile Ala 
145                 150                 155                 160 


His Leu Asn Ile Ser Lys Val Leu Leu Val Leu Gly Glu Thr Tyr Gly 
                165                 170                 175     


Glu Lys Glu Asp Pro Glu Gly Leu Gln Asp Phe Asn Thr Glu Ser Leu 
            180                 185                 190         


His Ile Val Phe Pro Thr Asn Lys Glu Phe His Phe Ile Leu Asp Val 
        195                 200                 205             


Ser Val Lys Thr Val Ala Asn Leu Glu Leu Ser Asn Ile Lys Cys Val 
    210                 215                 220                 


Leu Glu Asp Asn Lys Cys Ser Tyr Phe Leu Ser Ile Leu Ala Lys Leu 
225                 230                 235                 240 


Gln Thr Asn Pro Lys Leu Ser Asn Leu Thr Leu Asn Asn Ile Glu Thr 
                245                 250                 255     


Thr Trp Asn Ser Phe Ile Arg Ile Leu Gln Leu Val Trp His Thr Thr 
            260                 265                 270         


Val Trp Tyr Phe Ser Ile Ser Asn Val Lys Leu Gln Gly Gln Leu Asp 
        275                 280                 285             


Phe Arg Asp Phe Asp Tyr Ser Gly Thr Ser Leu Lys Ala Leu Ser Ile 
    290                 295                 300                 


His Gln Val Val Ser Asp Val Phe Gly Phe Pro Gln Ser Tyr Ile Tyr 
305                 310                 315                 320 


Glu Ile Phe Ser Asn Met Asn Ile Lys Asn Phe Thr Val Ser Gly Thr 
                325                 330                 335     


Arg Met Val His Met Leu Cys Pro Ser Lys Ile Ser Pro Phe Leu His 
            340                 345                 350         


Leu Asp Phe Ser Asn Asn Leu Leu Thr Asp Thr Val Phe Glu Asn Cys 
        355                 360                 365             


Gly His Leu Thr Glu Leu Glu Thr Leu Ile Leu Gln Met Asn Gln Leu 
    370                 375                 380                 


Lys Glu Leu Ser Lys Ile Ala Glu Met Thr Thr Gln Met Lys Ser Leu 
385                 390                 395                 400 


Gln Gln Leu Asp Ile Ser Gln Asn Ser Val Ser Tyr Asp Glu Lys Lys 
                405                 410                 415     


Gly Asp Cys Ser Trp Thr Lys Ser Leu Leu Ser Leu Asn Met Ser Ser 
            420                 425                 430         


Asn Ile Leu Thr Asp Thr Ile Phe Arg Cys Leu Pro Pro Arg Ile Lys 
        435                 440                 445             


Val Leu Asp Leu His Ser Asn Lys Ile Lys Ser Ile Pro Lys Gln Val 
    450                 455                 460                 


Val Lys Leu Glu Ala Leu Gln Glu Leu Asn Val Ala Phe Asn Ser Leu 
465                 470                 475                 480 


Thr Asp Leu Pro Gly Cys Gly Ser Phe Ser Ser Leu Ser Val Leu Ile 
                485                 490                 495     


Ile Asp His Asn Ser Val Ser His Pro Ser Ala Asp Phe Phe Gln Ser 
            500                 505                 510         


Cys Gln Lys Met Arg Ser Ile Lys Ala Gly Asp Asn Pro Phe Gln Cys 
        515                 520                 525             


Thr Cys Glu Leu Gly Glu Phe Val Lys Asn Ile Asp Gln Val Ser Ser 
    530                 535                 540                 


Glu Val Leu Glu Gly Trp Pro Asp Ser Tyr Lys Cys Asp Tyr Pro Glu 
545                 550                 555                 560 


Ser Tyr Arg Gly Thr Leu Leu Lys Asp Phe His Met Ser Glu Leu Ser 
                565                 570                 575     


Cys Asn Ile Thr Leu Leu Ile Val Thr Ile Val Ala Thr Met Leu Val 
            580                 585                 590         


Leu Ala Val Thr Val Thr Ser Leu Cys Ser Tyr Leu Asp Leu Pro Trp 
        595                 600                 605             


Tyr Leu Arg Met Val Cys Gln Trp Thr Gln Thr Arg Arg Arg Ala Arg 
    610                 615                 620                 


Asn Ile Pro Leu Glu Glu Leu Gln Arg Asn Leu Gln Phe His Ala Phe 
625                 630                 635                 640 


Ile Ser Tyr Ser Gly His Asp Ser Phe Trp Val Lys Asn Glu Leu Leu 
                645                 650                 655     


Pro Asn Leu Glu Lys Glu Gly Met Gln Ile Cys Leu His Glu Arg Asn 
            660                 665                 670         


Phe Val Pro Gly Lys Ser Ile Val Glu Asn Ile Ile Thr Cys Ile Glu 
        675                 680                 685             


Lys Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Ser 
    690                 695                 700                 


Glu Trp Cys His Tyr Glu Leu Tyr Phe Ala His His Asn Leu Phe His 
705                 710                 715                 720 


Glu Gly Ser Asn Ser Leu Ile Leu Ile Leu Leu Glu Pro Ile Pro Gln 
                725                 730                 735     


Tyr Ser Ile Pro Ser Ser Tyr His Lys Leu Lys Ser Leu Met Ala Arg 
            740                 745                 750         


Arg Thr Tyr Leu Glu Trp Pro Lys Glu Lys Ser Lys Arg Gly Leu Phe 
        755                 760                 765             


Trp Ala Asn Leu Arg Ala Ala Ile Asn Ile Lys Leu Thr Glu Gln Ala 
    770                 775                 780                 


Lys Lys 
785     


<210>  2807
<211>  784
<212>  PRT
<213>  Homo sapiens

<400>  2807

Met Pro His Thr Leu Trp Met Val Trp Val Leu Gly Val Ile Ile Ser 
1               5                   10                  15      


Leu Ser Lys Glu Glu Ser Ser Asn Gln Ala Ser Leu Ser Cys Asp Arg 
            20                  25                  30          


Asn Gly Ile Cys Lys Gly Ser Ser Gly Ser Leu Asn Ser Ile Pro Ser 
        35                  40                  45              


Gly Leu Thr Glu Ala Val Lys Ser Leu Asp Leu Ser Asn Asn Arg Ile 
    50                  55                  60                  


Thr Tyr Ile Ser Asn Ser Asp Leu Gln Arg Cys Val Asn Leu Gln Ala 
65                  70                  75                  80  


Leu Val Leu Thr Ser Asn Gly Ile Asn Thr Ile Glu Glu Asp Ser Phe 
                85                  90                  95      


Ser Ser Leu Gly Ser Leu Glu His Leu Asp Leu Ser Tyr Asn Tyr Leu 
            100                 105                 110         


Ser Asn Leu Ser Ser Ser Trp Phe Lys Pro Leu Ser Ser Leu Thr Phe 
        115                 120                 125             


Leu Asn Leu Leu Gly Asn Pro Tyr Lys Thr Leu Gly Glu Thr Ser Leu 
    130                 135                 140                 


Phe Ser His Leu Thr Lys Leu Gln Ile Leu Arg Val Gly Asn Met Asp 
145                 150                 155                 160 


Thr Phe Thr Lys Ile Gln Arg Lys Asp Phe Ala Gly Leu Thr Phe Leu 
                165                 170                 175     


Glu Glu Leu Glu Ile Asp Ala Ser Asp Leu Gln Ser Tyr Glu Pro Lys 
            180                 185                 190         


Ser Leu Lys Ser Ile Gln Asn Val Ser His Leu Ile Leu His Met Lys 
        195                 200                 205             


Gln His Ile Leu Leu Leu Glu Ile Phe Val Asp Val Thr Ser Ser Val 
    210                 215                 220                 


Glu Cys Leu Glu Leu Arg Asp Thr Asp Leu Asp Thr Phe His Phe Ser 
225                 230                 235                 240 


Glu Leu Ser Thr Gly Glu Thr Asn Ser Leu Ile Lys Lys Phe Thr Phe 
                245                 250                 255     


Arg Asn Val Lys Ile Thr Asp Glu Ser Leu Phe Gln Val Met Lys Leu 
            260                 265                 270         


Leu Asn Gln Ile Ser Gly Leu Leu Glu Leu Glu Phe Asp Asp Cys Thr 
        275                 280                 285             


Leu Asn Gly Val Gly Asn Phe Arg Ala Ser Asp Asn Asp Arg Val Ile 
    290                 295                 300                 


Asp Pro Gly Lys Val Glu Thr Leu Thr Ile Arg Arg Leu His Ile Pro 
305                 310                 315                 320 


Arg Phe Tyr Leu Phe Tyr Asp Leu Ser Thr Leu Tyr Ser Leu Thr Glu 
                325                 330                 335     


Arg Val Lys Arg Ile Thr Val Glu Asn Ser Lys Val Phe Leu Val Pro 
            340                 345                 350         


Cys Leu Leu Ser Gln His Leu Lys Ser Leu Glu Tyr Leu Asp Leu Ser 
        355                 360                 365             


Glu Asn Leu Met Val Glu Glu Tyr Leu Lys Asn Ser Ala Cys Glu Asp 
    370                 375                 380                 


Ala Trp Pro Ser Leu Gln Thr Leu Ile Leu Arg Gln Asn His Leu Ala 
385                 390                 395                 400 


Ser Leu Glu Lys Thr Gly Glu Thr Leu Leu Thr Leu Lys Asn Leu Thr 
                405                 410                 415     


Asn Ile Asp Ile Ser Lys Asn Ser Phe His Ser Met Pro Glu Thr Cys 
            420                 425                 430         


Gln Trp Pro Glu Lys Met Lys Tyr Leu Asn Leu Ser Ser Thr Arg Ile 
        435                 440                 445             


His Ser Val Thr Gly Cys Ile Pro Lys Thr Leu Glu Ile Leu Asp Val 
    450                 455                 460                 


Ser Asn Asn Asn Leu Asn Leu Phe Ser Leu Asn Leu Pro Gln Leu Lys 
465                 470                 475                 480 


Glu Leu Tyr Ile Ser Arg Asn Lys Leu Met Thr Leu Pro Asp Ala Ser 
                485                 490                 495     


Leu Leu Pro Met Leu Leu Val Leu Lys Ile Ser Arg Asn Ala Ile Thr 
            500                 505                 510         


Thr Phe Ser Lys Glu Gln Leu Asp Ser Phe His Thr Leu Lys Thr Leu 
        515                 520                 525             


Glu Ala Gly Gly Asn Asn Phe Ile Cys Ser Cys Glu Phe Leu Ser Phe 
    530                 535                 540                 


Thr Gln Glu Gln Gln Ala Leu Ala Lys Val Leu Ile Asp Trp Pro Ala 
545                 550                 555                 560 


Asn Tyr Leu Cys Asp Ser Pro Ser His Val Arg Gly Gln Gln Val Gln 
                565                 570                 575     


Asp Val Arg Leu Ser Val Ser Glu Cys His Arg Thr Ala Leu Val Ser 
            580                 585                 590         


Gly Met Cys Cys Ala Leu Phe Leu Leu Ile Leu Leu Thr Gly Val Leu 
        595                 600                 605             


Cys His Arg Phe His Gly Leu Trp Tyr Met Lys Met Met Trp Ala Trp 
    610                 615                 620                 


Leu Gln Ala Lys Arg Lys Pro Arg Lys Ala Pro Ser Arg Asn Ile Cys 
625                 630                 635                 640 


Tyr Asp Ala Phe Val Ser Tyr Ser Glu Arg Asp Ala Tyr Trp Val Glu 
                645                 650                 655     


Asn Leu Met Val Gln Glu Leu Glu Asn Phe Asn Pro Pro Phe Lys Leu 
            660                 665                 670         


Cys Leu His Lys Arg Asp Phe Ile Pro Gly Lys Trp Ile Ile Asp Asn 
        675                 680                 685             


Ile Ile Asp Ser Ile Glu Lys Ser His Lys Thr Val Phe Val Leu Ser 
    690                 695                 700                 


Glu Asn Phe Val Lys Ser Glu Trp Cys Lys Tyr Glu Leu Asp Phe Ser 
705                 710                 715                 720 


His Phe Arg Leu Phe Asp Glu Asn Asn Asp Ala Ala Ile Leu Ile Leu 
                725                 730                 735     


Leu Glu Pro Ile Glu Lys Lys Ala Ile Pro Gln Arg Phe Cys Lys Leu 
            740                 745                 750         


Arg Lys Ile Met Asn Thr Lys Thr Tyr Leu Glu Trp Pro Met Asp Glu 
        755                 760                 765             


Ala Gln Arg Glu Gly Phe Trp Val Asn Leu Arg Ala Ala Ile Lys Ser 
    770                 775                 780                 


<210>  2808
<211>  904
<212>  PRT
<213>  Homo sapiens

<400>  2808

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Ser Thr Thr Lys Cys Thr Val Ser His 
            20                  25                  30          


Glu Val Ala Asp Cys Ser His Leu Lys Leu Thr Gln Val Pro Asp Asp 
        35                  40                  45              


Leu Pro Thr Asn Ile Thr Val Leu Asn Leu Thr His Asn Gln Leu Arg 
    50                  55                  60                  


Arg Leu Pro Ala Ala Asn Phe Thr Arg Tyr Ser Gln Leu Thr Ser Leu 
65                  70                  75                  80  


Asp Val Gly Phe Asn Thr Ile Ser Lys Leu Glu Pro Glu Leu Cys Gln 
                85                  90                  95      


Lys Leu Pro Met Leu Lys Val Leu Asn Leu Gln His Asn Glu Leu Ser 
            100                 105                 110         


Gln Leu Ser Asp Lys Thr Phe Ala Phe Cys Thr Asn Leu Thr Glu Leu 
        115                 120                 125             


His Leu Met Ser Asn Ser Ile Gln Lys Ile Lys Asn Asn Pro Phe Val 
    130                 135                 140                 


Lys Gln Lys Asn Leu Ile Thr Leu Asp Leu Ser His Asn Gly Leu Ser 
145                 150                 155                 160 


Ser Thr Lys Leu Gly Thr Gln Val Gln Leu Glu Asn Leu Gln Glu Leu 
                165                 170                 175     


Leu Leu Ser Asn Asn Lys Ile Gln Ala Leu Lys Ser Glu Glu Leu Asp 
            180                 185                 190         


Ile Phe Ala Asn Ser Ser Leu Lys Lys Leu Glu Leu Ser Ser Asn Gln 
        195                 200                 205             


Ile Lys Glu Phe Ser Pro Gly Cys Phe His Ala Ile Gly Arg Leu Phe 
    210                 215                 220                 


Gly Leu Phe Leu Asn Asn Val Gln Leu Gly Pro Ser Leu Thr Glu Lys 
225                 230                 235                 240 


Leu Cys Leu Glu Leu Ala Asn Thr Ser Ile Arg Asn Leu Ser Leu Ser 
                245                 250                 255     


Asn Ser Gln Leu Ser Thr Thr Ser Asn Thr Thr Phe Leu Gly Leu Lys 
            260                 265                 270         


Trp Thr Asn Leu Thr Met Leu Asp Leu Ser Tyr Asn Asn Leu Asn Val 
        275                 280                 285             


Val Gly Asn Asp Ser Phe Ala Trp Leu Pro Gln Leu Glu Tyr Phe Phe 
    290                 295                 300                 


Leu Glu Tyr Asn Asn Ile Gln His Leu Phe Ser His Ser Leu His Gly 
305                 310                 315                 320 


Leu Phe Asn Val Arg Tyr Leu Asn Leu Lys Arg Ser Phe Thr Lys Gln 
                325                 330                 335     


Ser Ile Ser Leu Ala Ser Leu Pro Lys Ile Asp Asp Phe Ser Phe Gln 
            340                 345                 350         


Trp Leu Lys Cys Leu Glu His Leu Asn Met Glu Asp Asn Asp Ile Pro 
        355                 360                 365             


Gly Ile Lys Ser Asn Met Phe Thr Gly Leu Ile Asn Leu Lys Tyr Leu 
    370                 375                 380                 


Ser Leu Ser Asn Ser Phe Thr Ser Leu Arg Thr Leu Thr Asn Glu Thr 
385                 390                 395                 400 


Phe Val Ser Leu Ala His Ser Pro Leu His Ile Leu Asn Leu Thr Lys 
                405                 410                 415     


Asn Lys Ile Ser Lys Ile Glu Ser Asp Ala Phe Ser Trp Leu Gly His 
            420                 425                 430         


Leu Glu Val Leu Asp Leu Gly Leu Asn Glu Ile Gly Gln Glu Leu Thr 
        435                 440                 445             


Gly Gln Glu Trp Arg Gly Leu Glu Asn Ile Phe Glu Ile Tyr Leu Ser 
    450                 455                 460                 


Tyr Asn Lys Tyr Leu Gln Leu Thr Arg Asn Ser Phe Ala Leu Val Pro 
465                 470                 475                 480 


Ser Leu Gln Arg Leu Met Leu Arg Arg Val Ala Leu Lys Asn Val Asp 
                485                 490                 495     


Ser Ser Pro Ser Pro Phe Gln Pro Leu Arg Asn Leu Thr Ile Leu Asp 
            500                 505                 510         


Leu Ser Asn Asn Asn Ile Ala Asn Ile Asn Asp Asp Met Leu Glu Gly 
        515                 520                 525             


Leu Glu Lys Leu Glu Ile Leu Asp Leu Gln His Asn Asn Leu Ala Arg 
    530                 535                 540                 


Leu Trp Lys His Ala Asn Pro Gly Gly Pro Ile Tyr Phe Leu Lys Gly 
545                 550                 555                 560 


Leu Ser His Leu His Ile Leu Asn Leu Glu Ser Asn Gly Phe Asp Glu 
                565                 570                 575     


Ile Pro Val Glu Val Phe Lys Asp Leu Phe Glu Leu Lys Ile Ile Asp 
            580                 585                 590         


Leu Gly Leu Asn Asn Leu Asn Thr Leu Pro Ala Ser Val Phe Asn Asn 
        595                 600                 605             


Gln Val Ser Leu Lys Ser Leu Asn Leu Gln Lys Asn Leu Ile Thr Ser 
    610                 615                 620                 


Val Glu Lys Lys Val Phe Gly Pro Ala Phe Arg Asn Leu Thr Glu Leu 
625                 630                 635                 640 


Asp Met Arg Phe Asn Pro Phe Asp Cys Thr Cys Glu Ser Ile Ala Trp 
                645                 650                 655     


Phe Val Asn Trp Ile Asn Glu Thr His Thr Asn Ile Pro Glu Leu Ser 
            660                 665                 670         


Ser His Tyr Leu Cys Asn Thr Pro Pro His Tyr His Gly Phe Pro Val 
        675                 680                 685             


Arg Leu Phe Asp Thr Ser Ser Cys Lys Asp Ser Ala Pro Phe Glu Leu 
    690                 695                 700                 


Phe Phe Met Ile Asn Thr Ser Ile Leu Leu Ile Phe Ile Phe Ile Val 
705                 710                 715                 720 


Leu Leu Ile His Phe Glu Gly Trp Arg Ile Ser Phe Tyr Trp Asn Val 
                725                 730                 735     


Ser Val His Arg Val Leu Gly Phe Lys Glu Ile Asp Arg Gln Thr Glu 
            740                 745                 750         


Gln Phe Glu Tyr Ala Ala Tyr Ile Ile His Ala Tyr Lys Asp Lys Asp 
        755                 760                 765             


Trp Val Trp Glu His Phe Ser Ser Met Glu Lys Glu Asp Gln Ser Leu 
    770                 775                 780                 


Lys Phe Cys Leu Glu Glu Arg Asp Phe Glu Ala Gly Val Phe Glu Leu 
785                 790                 795                 800 


Glu Ala Ile Val Asn Ser Ile Lys Arg Ser Arg Lys Ile Ile Phe Val 
                805                 810                 815     


Ile Thr His His Leu Leu Lys Asp Pro Leu Cys Lys Arg Phe Lys Val 
            820                 825                 830         


His His Ala Val Gln Gln Ala Ile Glu Gln Asn Leu Asp Ser Ile Ile 
        835                 840                 845             


Leu Val Phe Leu Glu Glu Ile Pro Asp Tyr Lys Leu Asn His Ala Leu 
    850                 855                 860                 


Cys Leu Arg Arg Gly Met Phe Lys Ser His Cys Ile Leu Asn Trp Pro 
865                 870                 875                 880 


Val Gln Lys Glu Arg Ile Gly Ala Phe Arg His Lys Leu Gln Val Ala 
                885                 890                 895     


Leu Gly Ser Lys Asn Ser Val His 
            900                 


<210>  2809
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  2809

Met Gly Asp His Leu Asp Leu Leu Leu Gly Val Val Leu Met Ala Gly 
1               5                   10                  15      


Pro Val Phe Gly Ile Pro Ser Cys Ser Phe Asp Gly Arg Ile Ala Phe 
            20                  25                  30          


Tyr Arg Phe Cys Asn Leu Thr Gln Val Pro Gln Val Leu Asn Thr Thr 
        35                  40                  45              


Glu Arg Leu Leu Leu Ser Phe Asn Tyr Ile Arg Thr Val Thr Ala Ser 
    50                  55                  60                  


Ser Phe Pro Phe Leu Glu Gln Leu Gln Leu Leu Glu Leu Gly Ser Gln 
65                  70                  75                  80  


Tyr Thr Pro Leu Thr Ile Asp Lys Glu Ala Phe Arg Asn Leu Pro Asn 
                85                  90                  95      


Leu Arg Ile Leu Asp Leu Gly Ser Ser Lys Ile Tyr Phe Leu His Pro 
            100                 105                 110         


Asp Ala Phe Gln Gly Leu Phe His Leu Phe Glu Leu Arg Leu Tyr Phe 
        115                 120                 125             


Cys Gly Leu Ser Asp Ala Val Leu Lys Asp Gly Tyr Phe Arg Asn Leu 
    130                 135                 140                 


Lys Ala Leu Thr Arg Leu Asp Leu Ser Lys Asn Gln Ile Arg Ser Leu 
145                 150                 155                 160 


Tyr Leu His Pro Ser Phe Gly Lys Leu Asn Ser Leu Lys Ser Ile Asp 
                165                 170                 175     


Phe Ser Ser Asn Gln Ile Phe Leu Val Cys Glu His Glu Leu Glu Pro 
            180                 185                 190         


Leu Gln Gly Lys Thr Leu Ser Phe Phe Ser Leu Ala Ala Asn Ser Leu 
        195                 200                 205             


Tyr Ser Arg Val Ser Val Asp Trp Gly Lys Cys Met Asn Pro Phe Arg 
    210                 215                 220                 


Asn Met Val Leu Glu Ile Leu Asp Val Ser Gly Asn Gly Trp Thr Val 
225                 230                 235                 240 


Asp Ile Thr Gly Asn Phe Ser Asn Ala Ile Ser Lys Ser Gln Ala Phe 
                245                 250                 255     


Ser Leu Ile Leu Ala His His Ile Met Gly Ala Gly Phe Gly Phe His 
            260                 265                 270         


Asn Ile Lys Asp Pro Asp Gln Asn Thr Phe Ala Gly Leu Ala Arg Ser 
        275                 280                 285             


Ser Val Arg His Leu Asp Leu Ser His Gly Phe Val Phe Ser Leu Asn 
    290                 295                 300                 


Ser Arg Val Phe Glu Thr Leu Lys Asp Leu Lys Val Leu Asn Leu Ala 
305                 310                 315                 320 


Tyr Asn Lys Ile Asn Lys Ile Ala Asp Glu Ala Phe Tyr Gly Leu Asp 
                325                 330                 335     


Asn Leu Gln Val Leu Asn Leu Ser Tyr Asn Leu Leu Gly Glu Leu Tyr 
            340                 345                 350         


Ser Ser Asn Phe Tyr Gly Leu Pro Lys Val Ala Tyr Ile Asp Leu Gln 
        355                 360                 365             


Lys Asn His Ile Ala Ile Ile Gln Asp Gln Thr Phe Lys Phe Leu Glu 
    370                 375                 380                 


Lys Leu Gln Thr Leu Asp Leu Arg Asp Asn Ala Leu Thr Thr Ile His 
385                 390                 395                 400 


Phe Ile Pro Ser Ile Pro Asp Ile Phe Leu Ser Gly Asn Lys Leu Val 
                405                 410                 415     


Thr Leu Pro Lys Ile Asn Leu Thr Ala Asn Leu Ile His Leu Ser Glu 
            420                 425                 430         


Asn Arg Leu Glu Asn Leu Asp Ile Leu Tyr Phe Leu Leu Arg Val Pro 
        435                 440                 445             


His Leu Gln Ile Leu Ile Leu Asn Gln Asn Arg Phe Ser Ser Cys Ser 
    450                 455                 460                 


Gly Asp Gln Thr Pro Ser Glu Asn Pro Ser Leu Glu Gln Leu Phe Leu 
465                 470                 475                 480 


Gly Glu Asn Met Leu Gln Leu Ala Trp Glu Thr Glu Leu Cys Trp Asp 
                485                 490                 495     


Val Phe Glu Gly Leu Ser His Leu Gln Val Leu Tyr Leu Asn His Asn 
            500                 505                 510         


Tyr Leu Asn Ser Leu Pro Pro Gly Val Phe Ser His Leu Thr Ala Leu 
        515                 520                 525             


Arg Gly Leu Ser Leu Asn Ser Asn Arg Leu Thr Val Leu Ser His Asn 
    530                 535                 540                 


Asp Leu Pro Ala Asn Leu Glu Ile Leu Asp Ile Ser Arg Asn Gln Leu 
545                 550                 555                 560 


Leu Ala Pro Asn Pro Asp Val Phe Val Ser Leu Ser Val Leu Asp Ile 
                565                 570                 575     


Thr His Asn Lys Phe Ile Cys Glu Cys Glu Leu Ser Thr Phe Ile Asn 
            580                 585                 590         


Trp Leu Asn His Thr Asn Val Thr Ile Ala Gly Pro Pro Ala Asp Ile 
        595                 600                 605             


Tyr Cys Val Tyr Pro Asp Ser Phe Ser Gly Val Ser Leu Phe Ser Leu 
    610                 615                 620                 


Ser Thr Glu Gly Cys Asp Glu Glu Glu Val Leu Lys Ser Leu Lys Phe 
625                 630                 635                 640 


Ser Leu Phe Ile Val Cys Thr Val Thr Leu Thr Leu Phe Leu Met Thr 
                645                 650                 655     


Ile Leu Thr Val Thr Lys Phe Arg Gly Phe Cys Phe Ile Cys Tyr Lys 
            660                 665                 670         


Thr Ala Gln Arg Leu Val Phe Lys Asp His Pro Gln Gly Thr Glu Pro 
        675                 680                 685             


Asp Met Tyr Lys Tyr Asp Ala Tyr Leu Cys Phe Ser Ser Lys Asp Phe 
    690                 695                 700                 


Thr Trp Val Gln Asn Ala Leu Leu Lys His Leu Asp Thr Gln Tyr Ser 
705                 710                 715                 720 


Asp Gln Asn Arg Phe Asn Leu Cys Phe Glu Glu Arg Asp Phe Val Pro 
                725                 730                 735     


Gly Glu Asn Arg Ile Ala Asn Ile Gln Asp Ala Ile Trp Asn Ser Arg 
            740                 745                 750         


Lys Ile Val Cys Leu Val Ser Arg His Phe Leu Arg Asp Gly Trp Cys 
        755                 760                 765             


Leu Glu Ala Phe Ser Tyr Ala Gln Gly Arg Cys Leu Ser Asp Leu Asn 
    770                 775                 780                 


Ser Ala Leu Ile Met Val Val Val Gly Ser Leu Ser Gln Tyr Gln Leu 
785                 790                 795                 800 


Met Lys His Gln Ser Ile Arg Gly Phe Val Gln Lys Gln Gln Tyr Leu 
                805                 810                 815     


Arg Trp Pro Glu Asp Leu Gln Asp Val Gly Trp Phe Leu His Lys Leu 
            820                 825                 830         


Ser Gln Gln Ile Leu Lys Lys Glu Lys Glu Lys Lys Lys Asp Asn Asn 
        835                 840                 845             


Ile Pro Leu Gln Thr Val Ala Thr Ile Ser 
    850                 855             


<210>  2810
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  2810

Met Ala Ser Pro Ser Arg Arg Leu Gln Thr Lys Pro Val Ile Thr Cys 
1               5                   10                  15      


Phe Lys Ser Val Leu Leu Ile Tyr Thr Phe Ile Phe Trp Ile Thr Gly 
            20                  25                  30          


Val Ile Leu Leu Ala Val Gly Ile Trp Gly Lys Val Ser Leu Glu Asn 
        35                  40                  45              


Tyr Phe Ser Leu Leu Asn Glu Lys Ala Thr Asn Val Pro Phe Val Leu 
    50                  55                  60                  


Ile Ala Thr Gly Thr Val Ile Ile Leu Leu Gly Thr Phe Gly Cys Phe 
65                  70                  75                  80  


Ala Thr Cys Arg Ala Ser Ala Trp Met Leu Lys Leu Tyr Ala Met Phe 
                85                  90                  95      


Leu Thr Leu Val Phe Leu Val Glu Leu Val Ala Ala Ile Val Gly Phe 
            100                 105                 110         


Val Phe Arg His Glu Ile Lys Asn Ser Phe Lys Asn Asn Tyr Glu Lys 
        115                 120                 125             


Ala Leu Lys Gln Tyr Asn Ser Thr Gly Asp Tyr Arg Ser His Ala Val 
    130                 135                 140                 


Asp Lys Ile Gln Asn Thr Leu His Cys Cys Gly Val Thr Asp Tyr Arg 
145                 150                 155                 160 


Asp Trp Thr Asp Thr Asn Tyr Tyr Ser Glu Lys Gly Phe Pro Lys Ser 
                165                 170                 175     


Cys Cys Lys Leu Glu Asp Cys Thr Pro Gln Arg Asp Ala Asp Lys Val 
            180                 185                 190         


Asn Asn Glu Gly Cys Phe Ile Lys Val Met Thr Ile Ile Glu Ser Glu 
        195                 200                 205             


Met Gly Val Val Ala Gly Ile Ser Phe Gly Val Ala Cys Phe Gln Leu 
    210                 215                 220                 


Ile Gly Ile Phe Leu Ala Tyr Cys Leu Ser Arg Ala Ile Thr Asn Asn 
225                 230                 235                 240 


Gln Tyr Glu Ile Val 
                245 


<210>  2811
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  2811

Met Ala Arg Ala Cys Leu Gln Ala Val Lys Tyr Leu Met Phe Ala Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Leu Gly Gly Cys Gly Val Leu Gly Val Gly Ile 
            20                  25                  30          


Trp Leu Ala Ala Thr Gln Gly Ser Phe Ala Thr Leu Ser Ser Ser Phe 
        35                  40                  45              


Pro Ser Leu Ser Ala Ala Asn Leu Leu Ile Ile Thr Gly Ala Phe Val 
    50                  55                  60                  


Met Ala Ile Gly Phe Val Gly Cys Leu Gly Ala Ile Lys Glu Asn Lys 
65                  70                  75                  80  


Cys Leu Leu Leu Thr Phe Phe Leu Leu Leu Leu Leu Val Phe Leu Leu 
                85                  90                  95      


Glu Ala Thr Ile Ala Ile Leu Phe Phe Ala Tyr Thr Asp Lys Ile Asp 
            100                 105                 110         


Arg Tyr Ala Gln Gln Asp Leu Lys Lys Gly Leu His Leu Tyr Gly Thr 
        115                 120                 125             


Gln Gly Asn Val Gly Leu Thr Asn Ala Trp Ser Ile Ile Gln Thr Asp 
    130                 135                 140                 


Phe Arg Cys Cys Gly Val Ser Asn Tyr Thr Asp Trp Phe Glu Val Tyr 
145                 150                 155                 160 


Asn Ala Thr Arg Val Pro Asp Ser Cys Cys Leu Glu Phe Ser Glu Ser 
                165                 170                 175     


Cys Gly Leu His Ala Pro Gly Thr Trp Trp Lys Ala Pro Cys Tyr Glu 
            180                 185                 190         


Thr Val Lys Val Trp Leu Gln Glu Asn Leu Leu Ala Val Gly Ile Phe 
        195                 200                 205             


Gly Leu Cys Thr Ala Leu Val Gln Ile Leu Gly Leu Thr Phe Ala Met 
    210                 215                 220                 


Thr Met Tyr Cys Gln Val Val Lys Ala Asp Thr Tyr Cys Ala 
225                 230                 235             


<210>  2812
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  2812

Met Arg Pro Glu Arg Pro Arg Pro Arg Gly Ser Ala Pro Gly Pro Met 
1               5                   10                  15      


Glu Thr Pro Pro Trp Asp Pro Ala Arg Asn Asp Ser Leu Pro Pro Thr 
            20                  25                  30          


Leu Thr Pro Ala Val Pro Pro Tyr Val Lys Leu Gly Leu Thr Val Val 
        35                  40                  45              


Tyr Thr Val Phe Tyr Ala Leu Leu Phe Val Phe Ile Tyr Val Gln Leu 
    50                  55                  60                  


Trp Leu Val Leu Arg Tyr Arg His Lys Arg Leu Ser Tyr Gln Ser Val 
65                  70                  75                  80  


Phe Leu Phe Leu Cys Leu Phe Trp Ala Ser Leu Arg Thr Val Leu Phe 
                85                  90                  95      


Ser Phe Tyr Phe Lys Asp Phe Val Ala Ala Asn Ser Leu Ser Pro Phe 
            100                 105                 110         


Val Phe Trp Leu Leu Tyr Cys Phe Pro Val Cys Leu Gln Phe Phe Thr 
        115                 120                 125             


Leu Thr Leu Met Asn Leu Tyr Phe Thr Gln Val Ile Phe Lys Ala Lys 
    130                 135                 140                 


Ser Lys Tyr Ser Pro Glu Leu Leu Lys Tyr Arg Leu Pro Leu Tyr Leu 
145                 150                 155                 160 


Ala Ser Leu Phe Ile Ser Leu Val Phe Leu Leu Val Asn Leu Thr Cys 
                165                 170                 175     


Ala Val Leu Val Lys Thr Gly Asn Trp Glu Arg Lys Val Ile Val Ser 
            180                 185                 190         


Val Arg Val Ala Ile Asn Asp Thr Leu Phe Val Leu Cys Ala Val Ser 
        195                 200                 205             


Leu Ser Ile Cys Leu Tyr Lys Ile Ser Lys Met Ser Leu Ala Asn Ile 
    210                 215                 220                 


Tyr Leu Glu Ser Lys Gly Ser Ser Val Cys Gln Val Thr Ala Ile Gly 
225                 230                 235                 240 


Val Thr Val Ile Leu Leu Tyr Thr Ser Arg Ala Cys Tyr Asn Leu Phe 
                245                 250                 255     


Ile Leu Ser Phe Ser Gln Asn Lys Ser Val His Ser Phe Asp Tyr Asp 
            260                 265                 270         


Trp Tyr Asn Val Ser Asp Gln Ala Asp Leu Lys Asn Gln Leu Gly Asp 
        275                 280                 285             


Ala Gly Tyr Val Leu Phe Gly Val Val Leu Phe Val Trp Glu Leu Leu 
    290                 295                 300                 


Pro Thr Thr Leu Val Val Tyr Phe Phe Arg Val Arg Asn Pro Thr Lys 
305                 310                 315                 320 


Asp Leu Thr Asn Pro Gly Met Val Pro Ser His Gly Phe Ser Pro Arg 
                325                 330                 335     


Ser Tyr Phe Phe Asp Asn Pro Arg Arg Tyr Asp Ser Asp Asp Asp Leu 
            340                 345                 350         


Ala Trp Asn Ile Ala Pro Gln Gly Leu Gln Gly Gly Phe Ala Pro Asp 
        355                 360                 365             


Tyr Tyr Asp Trp Gly Gln Gln Thr Asn Ser Phe Leu Ala Gln Ala Gly 
    370                 375                 380                 


Thr Leu Gln Asp Ser Thr Leu Asp Pro Asp Lys Pro Ser Leu Gly 
385                 390                 395                 


<210>  2813
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  2813

Met Ala Pro Thr Gln Gly Pro Arg Ala Pro Leu Glu Phe Gly Gly Pro 
1               5                   10                  15      


Leu Gly Ala Ala Ala Leu Leu Leu Leu Leu Pro Ala Thr Met Phe His 
            20                  25                  30          


Leu Leu Leu Ala Ala Arg Ser Gly Pro Ala Arg Leu Leu Gly Pro Pro 
        35                  40                  45              


Ala Ser Leu Pro Gly Leu Glu Val Leu Trp Ser Pro Arg Ala Leu Leu 
    50                  55                  60                  


Leu Trp Leu Ala Trp Leu Gly Leu Gln Ala Ala Leu Tyr Leu Leu Pro 
65                  70                  75                  80  


Ala Arg Lys Val Ala Glu Gly Gln Glu Leu Lys Asp Lys Ser Arg Leu 
                85                  90                  95      


Arg Tyr Pro Ile Asn Gly Phe Gln Ala Leu Val Leu Thr Ala Leu Leu 
            100                 105                 110         


Val Gly Leu Gly Met Ser Ala Gly Leu Pro Leu Gly Ala Leu Pro Glu 
        115                 120                 125             


Met Leu Leu Pro Leu Ala Phe Val Ala Thr Leu Thr Ala Phe Ile Phe 
    130                 135                 140                 


Ser Leu Phe Leu Tyr Met Lys Ala Gln Val Ala Pro Val Ser Ala Leu 
145                 150                 155                 160 


Ala Pro Gly Gly Asn Ser Gly Asn Pro Ile Tyr Asp Phe Phe Leu Gly 
                165                 170                 175     


Arg Glu Leu Asn Pro Arg Ile Cys Phe Phe Asp Phe Lys Tyr Phe Cys 
            180                 185                 190         


Glu Leu Arg Pro Gly Leu Ile Gly Trp Val Leu Ile Asn Leu Ala Leu 
        195                 200                 205             


Leu Met Lys Glu Ala Glu Leu Arg Gly Ser Pro Ser Leu Ala Met Trp 
    210                 215                 220                 


Leu Val Asn Gly Phe Gln Leu Leu Tyr Val Gly Asp Ala Leu Trp His 
225                 230                 235                 240 


Glu Glu Ala Val Leu Thr Thr Met Asp Ile Thr His Asp Gly Phe Gly 
                245                 250                 255     


Phe Met Leu Ala Phe Gly Asp Met Ala Trp Val Pro Phe Thr Tyr Ser 
            260                 265                 270         


Leu Gln Ala Gln Phe Leu Leu His His Pro Gln Pro Leu Gly Leu Pro 
        275                 280                 285             


Met Ala Ser Val Ile Cys Leu Ile Asn Ala Thr Gly Tyr Tyr Ile Phe 
    290                 295                 300                 


Arg Gly Ala Asn Ser Gln Lys Asn Thr Phe Arg Lys Asn Pro Ser Asp 
305                 310                 315                 320 


Pro Arg Val Ala Gly Leu Glu Thr Ile Ser Thr Ala Thr Gly Arg Lys 
                325                 330                 335     


Leu Leu Val Ser Gly Trp Trp Gly Met Val Arg His Pro Asn Tyr Leu 
            340                 345                 350         


Gly Asp Leu Ile Met Ala Leu Ala Trp Ser Leu Pro Cys Gly Val Ser 
        355                 360                 365             


His Leu Leu Pro Tyr Phe Tyr Leu Leu Tyr Phe Thr Ala Leu Leu Val 
    370                 375                 380                 


His Arg Glu Ala Arg Asp Glu Arg Gln Cys Leu Gln Lys Tyr Gly Leu 
385                 390                 395                 400 


Ala Trp Gln Glu Tyr Cys Arg Arg Val Pro Tyr Arg Ile Met Pro Tyr 
                405                 410                 415     


Ile Tyr 
        


<210>  2814
<211>  694
<212>  PRT
<213>  Homo sapiens

<400>  2814

Met Pro Glu Phe Leu Glu Asp Pro Ser Val Leu Thr Lys Asp Lys Leu 
1               5                   10                  15      


Lys Ser Glu Leu Val Ala Asn Asn Val Thr Leu Pro Ala Gly Glu Gln 
            20                  25                  30          


Arg Lys Asp Val Tyr Val Gln Leu Tyr Leu Gln His Leu Thr Ala Arg 
        35                  40                  45              


Asn Arg Pro Pro Leu Pro Ala Gly Thr Asn Ser Lys Gly Pro Pro Asp 
    50                  55                  60                  


Phe Ser Ser Asp Glu Glu Arg Glu Pro Thr Pro Val Leu Gly Ser Gly 
65                  70                  75                  80  


Ala Ala Ala Ala Gly Arg Ser Arg Ala Ala Val Gly Arg Lys Ala Thr 
                85                  90                  95      


Lys Lys Thr Asp Lys Pro Arg Gln Glu Asp Lys Asp Asp Leu Asp Val 
            100                 105                 110         


Thr Glu Leu Thr Asn Glu Asp Leu Leu Asp Gln Leu Val Lys Tyr Gly 
        115                 120                 125             


Val Asn Pro Gly Pro Ile Val Gly Thr Thr Arg Lys Leu Tyr Glu Lys 
    130                 135                 140                 


Lys Leu Leu Lys Leu Arg Glu Gln Gly Thr Glu Ser Arg Ser Ser Thr 
145                 150                 155                 160 


Pro Leu Pro Thr Ile Ser Ser Ser Ala Glu Asn Thr Arg Gln Asn Gly 
                165                 170                 175     


Ser Asn Asp Ser Asp Arg Tyr Ser Asp Asn Glu Glu Gly Lys Lys Lys 
            180                 185                 190         


Glu His Lys Lys Val Lys Ser Thr Arg Asp Ile Val Pro Phe Ser Glu 
        195                 200                 205             


Leu Gly Thr Thr Pro Ser Gly Gly Gly Phe Phe Gln Gly Ile Ser Phe 
    210                 215                 220                 


Pro Glu Ile Ser Thr Arg Pro Pro Leu Gly Ser Thr Glu Leu Gln Ala 
225                 230                 235                 240 


Ala Lys Lys Val His Thr Ser Lys Gly Asp Leu Pro Arg Glu Pro Leu 
                245                 250                 255     


Val Ala Thr Asn Leu Pro Gly Arg Gly Gln Leu Gln Lys Leu Ala Ser 
            260                 265                 270         


Glu Arg Asn Leu Phe Ile Ser Cys Lys Ser Ser His Asp Arg Cys Leu 
        275                 280                 285             


Glu Lys Ser Ser Ser Ser Ser Ser Gln Pro Glu His Ser Ala Met Leu 
    290                 295                 300                 


Val Ser Thr Ala Ala Ser Pro Ser Leu Ile Lys Glu Thr Thr Thr Gly 
305                 310                 315                 320 


Tyr Tyr Lys Asp Ile Val Glu Asn Ile Cys Gly Arg Glu Lys Ser Gly 
                325                 330                 335     


Ile Gln Pro Leu Cys Pro Glu Arg Ser His Ile Ser Asp Gln Ser Pro 
            340                 345                 350         


Leu Ser Ser Lys Arg Lys Ala Leu Glu Glu Ser Glu Ser Ser Gln Leu 
        355                 360                 365             


Ile Ser Pro Pro Leu Ala Gln Ala Ile Arg Asp Tyr Val Asn Ser Leu 
    370                 375                 380                 


Leu Val Gln Gly Gly Val Gly Ser Leu Pro Gly Thr Ser Asn Ser Met 
385                 390                 395                 400 


Pro Pro Leu Asp Val Glu Asn Ile Gln Lys Arg Ile Asp Gln Ser Lys 
                405                 410                 415     


Phe Gln Glu Thr Glu Phe Leu Ser Pro Pro Arg Lys Val Pro Arg Leu 
            420                 425                 430         


Ser Glu Lys Ser Val Glu Glu Arg Asp Ser Gly Ser Phe Val Ala Phe 
        435                 440                 445             


Gln Asn Ile Pro Gly Ser Glu Leu Met Ser Ser Phe Ala Lys Thr Val 
    450                 455                 460                 


Val Ser His Ser Leu Thr Thr Leu Gly Leu Glu Val Ala Lys Gln Ser 
465                 470                 475                 480 


Gln His Asp Lys Ile Asp Ala Ser Glu Leu Ser Phe Pro Phe His Glu 
                485                 490                 495     


Ser Ile Leu Lys Val Ile Glu Glu Glu Trp Gln Gln Val Asp Arg Gln 
            500                 505                 510         


Leu Pro Ser Leu Ala Cys Lys Tyr Pro Val Ser Ser Arg Glu Ala Thr 
        515                 520                 525             


Gln Ile Leu Ser Val Pro Lys Val Asp Asp Glu Ile Leu Gly Phe Ile 
    530                 535                 540                 


Ser Glu Ala Thr Pro Leu Gly Gly Ile Gln Ala Ala Ser Thr Glu Ser 
545                 550                 555                 560 


Cys Asn Gln Gln Leu Asp Leu Ala Leu Cys Arg Ala Tyr Glu Ala Ala 
                565                 570                 575     


Ala Ser Ala Leu Gln Ile Ala Thr His Thr Ala Phe Val Ala Lys Ala 
            580                 585                 590         


Met Gln Ala Asp Ile Ser Gln Ala Ala Gln Ile Leu Ser Ser Asp Pro 
        595                 600                 605             


Ser Arg Thr His Gln Ala Leu Gly Ile Leu Ser Lys Thr Tyr Asp Ala 
    610                 615                 620                 


Ala Ser Tyr Ile Cys Glu Ala Ala Phe Asp Glu Val Lys Met Ala Ala 
625                 630                 635                 640 


His Thr Met Gly Asn Ala Thr Val Gly Arg Arg Tyr Leu Trp Leu Lys 
                645                 650                 655     


Asp Cys Lys Ile Asn Leu Ala Ser Lys Asn Lys Leu Ala Ser Thr Pro 
            660                 665                 670         


Phe Lys Gly Gly Thr Leu Phe Gly Gly Glu Val Cys Lys Val Ile Lys 
        675                 680                 685             


Lys Arg Gly Asn Lys His 
    690                 


<210>  2815
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  2815

Met Thr Arg Ala Arg Ile Gly Cys Phe Gly Pro Gly Gly Arg Ala Arg 
1               5                   10                  15      


Gly Thr Glu Ser Ala Pro Glu Pro Ser Lys Arg Val Pro Pro Gly Arg 
            20                  25                  30          


Ser Trp Gln Thr Gln Glu Val Arg Gln Thr Arg Gly Ala Asn Gly Leu 
        35                  40                  45              


Gly Pro Arg Ala Gly Ser Ala Gly Ala Lys Ala Pro Gly Pro Ala Gln 
    50                  55                  60                  


Gly Ala Ala Gln His Gly Leu Gly Gly Ser Ala Gly Leu Arg Val Arg 
65                  70                  75                  80  


Val Ser Pro Leu Ala Met Gly Ser Ala Ala Leu Glu Ile Leu Gly Leu 
                85                  90                  95      


Val Leu Cys Leu Val Gly Trp Gly Gly Leu Ile Leu Ala Cys Gly Leu 
            100                 105                 110         


Pro Met Trp Gln Val Thr Ala Phe Leu Asp His Asn Ile Val Thr Ala 
        115                 120                 125             


Gln Thr Thr Trp Lys Gly Leu Trp Met Ser Cys Val Val Gln Ser Thr 
    130                 135                 140                 


Gly His Met Gln Cys Lys Val Tyr Asp Ser Val Leu Ala Leu Ser Thr 
145                 150                 155                 160 


Glu Val Gln Ala Ala Arg Ala Leu Thr Val Ser Ala Val Leu Leu Ala 
                165                 170                 175     


Phe Val Ala Leu Phe Val Thr Leu Ala Gly Ala Gln Cys Thr Thr Cys 
            180                 185                 190         


Val Ala Pro Gly Pro Ala Lys Ala Arg Val Ala Leu Thr Gly Gly Val 
        195                 200                 205             


Leu Tyr Leu Phe Cys Gly Leu Leu Ala Leu Val Pro Leu Cys Trp Phe 
    210                 215                 220                 


Ala Asn Ile Val Val Arg Glu Phe Tyr Asp Pro Ser Val Pro Val Ser 
225                 230                 235                 240 


Gln Lys Tyr Glu Leu Gly Ala Ala Leu Tyr Ile Gly Trp Ala Ala Thr 
                245                 250                 255     


Ala Leu Leu Met Val Gly Gly Cys Leu Leu Cys Cys Gly Ala Trp Val 
            260                 265                 270         


Cys Thr Gly Arg Pro Asp Leu Ser Phe Pro Val Lys Tyr Ser Ala Pro 
        275                 280                 285             


Arg Arg Pro Thr Ala Thr Gly Asp Tyr Asp Lys Lys Asn Tyr Val 
    290                 295                 300             


<210>  2816
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  2816

Met Glu Asn Glu Thr Val Ser Glu Leu Asn Gln Thr Gln Leu Gln Pro 
1               5                   10                  15      


Arg Ala Val Val Ala Leu Glu Tyr Gln Val Val Thr Ile Leu Leu Val 
            20                  25                  30          


Leu Ile Ile Cys Gly Leu Gly Ile Val Gly Asn Ile Met Val Val Leu 
        35                  40                  45              


Val Val Met Arg Thr Lys His Met Arg Thr Pro Thr Asn Cys Tyr Leu 
    50                  55                  60                  


Val Ser Leu Ala Val Ala Asp Leu Met Val Leu Val Ala Ala Gly Leu 
65                  70                  75                  80  


Pro Asn Ile Thr Asp Ser Ile Tyr Gly Ser Trp Val Tyr Gly Tyr Val 
                85                  90                  95      


Gly Cys Leu Cys Ile Thr Tyr Leu Gln Tyr Leu Gly Ile Asn Ala Ser 
            100                 105                 110         


Ser Cys Ser Ile Thr Ala Phe Thr Ile Glu Arg Tyr Ile Ala Ile Cys 
        115                 120                 125             


His Pro Ile Lys Ala Gln Phe Leu Cys Thr Phe Ser Arg Ala Lys Lys 
    130                 135                 140                 


Ile Ile Ile Phe Val Trp Ala Phe Thr Ser Leu Tyr Cys Met Leu Trp 
145                 150                 155                 160 


Phe Phe Leu Leu Asp Leu Asn Ile Ser Thr Tyr Lys Asp Ala Ile Val 
                165                 170                 175     


Ile Ser Cys Gly Tyr Lys Ile Ser Arg Asn Tyr Tyr Ser Pro Ile Tyr 
            180                 185                 190         


Leu Met Asp Phe Gly Val Phe Tyr Val Val Pro Met Ile Leu Ala Thr 
        195                 200                 205             


Val Leu Tyr Gly Phe Ile Ala Arg Ile Leu Phe Leu Asn Pro Ile Pro 
    210                 215                 220                 


Ser Asp Pro Lys Glu Asn Ser Lys Thr Trp Lys Asn Asp Ser Thr His 
225                 230                 235                 240 


Gln Asn Thr Asn Leu Asn Val Asn Thr Ser Asn Arg Cys Phe Asn Ser 
                245                 250                 255     


Thr Val Ser Ser Arg Lys Gln Val Thr Lys Met Leu Ala Val Val Val 
            260                 265                 270         


Ile Leu Phe Ala Leu Leu Trp Met Pro Tyr Arg Thr Leu Val Val Val 
        275                 280                 285             


Asn Ser Phe Leu Ser Ser Pro Phe Gln Glu Asn Trp Phe Leu Leu Phe 
    290                 295                 300                 


Cys Arg Ile Cys Ile Tyr Leu Asn Ser Ala Ile Asn Pro Val Ile Tyr 
305                 310                 315                 320 


Asn Leu Met Ser Gln Lys Phe Arg Ala Ala Phe Arg Lys Leu Cys Asn 
                325                 330                 335     


Cys Lys Gln Lys Pro Thr Glu Lys Pro Ala Asn Tyr Ser Val Ala Leu 
            340                 345                 350         


Asn Tyr Ser Val Ile Lys Glu Ser Asp His Phe Ser Thr Glu Leu Asp 
        355                 360                 365             


Asp Ile Thr Val Thr Asp Thr Tyr Leu Ser Ala Thr Lys Val Ser Phe 
    370                 375                 380                 


Asp Asp Thr Cys Leu Ala Ser Glu Val Ser Phe Ser Gln Ser 
385                 390                 395             


<210>  2817
<211>  759
<212>  PRT
<213>  Homo sapiens

<400>  2817

Met Met Ala Ala Leu Tyr Pro Ser Thr Asp Leu Ser Gly Ala Ser Ser 
1               5                   10                  15      


Ser Ser Leu Pro Ser Ser Pro Ser Ser Ser Ser Pro Asn Glu Val Met 
            20                  25                  30          


Ala Leu Lys Asp Val Arg Glu Val Lys Glu Glu Asn Thr Leu Asn Glu 
        35                  40                  45              


Lys Leu Phe Leu Leu Ala Cys Asp Lys Gly Asp Tyr Tyr Met Val Lys 
    50                  55                  60                  


Lys Ile Leu Glu Glu Asn Ser Ser Gly Asp Leu Asn Ile Asn Cys Val 
65                  70                  75                  80  


Asp Val Leu Gly Arg Asn Ala Val Thr Ile Thr Ile Glu Asn Glu Asn 
                85                  90                  95      


Leu Asp Ile Leu Gln Leu Leu Leu Asp Tyr Gly Cys Gln Lys Leu Met 
            100                 105                 110         


Glu Arg Ile Gln Asn Pro Glu Tyr Ser Thr Thr Met Asp Val Ala Pro 
        115                 120                 125             


Val Ile Leu Ala Ala His Arg Asn Asn Tyr Glu Ile Leu Thr Met Leu 
    130                 135                 140                 


Leu Lys Gln Asp Val Ser Leu Pro Lys Pro His Ala Val Gly Cys Glu 
145                 150                 155                 160 


Cys Thr Leu Cys Ser Ala Lys Asn Lys Lys Asp Ser Leu Arg His Ser 
                165                 170                 175     


Arg Phe Arg Leu Asp Ile Tyr Arg Cys Leu Ala Ser Pro Ala Leu Ile 
            180                 185                 190         


Met Leu Thr Glu Glu Asp Pro Ile Leu Arg Ala Phe Glu Leu Ser Ala 
        195                 200                 205             


Asp Leu Lys Glu Leu Ser Leu Val Glu Val Glu Phe Arg Asn Asp Tyr 
    210                 215                 220                 


Glu Glu Leu Ala Arg Gln Cys Lys Met Phe Ala Lys Asp Leu Leu Ala 
225                 230                 235                 240 


Gln Ala Arg Asn Ser Arg Glu Leu Glu Val Ile Leu Asn His Thr Ser 
                245                 250                 255     


Ser Asp Glu Pro Leu Asp Lys Arg Gly Leu Leu Glu Glu Arg Met Asn 
            260                 265                 270         


Leu Ser Arg Leu Lys Leu Ala Ile Lys Tyr Asn Gln Lys Glu Phe Val 
        275                 280                 285             


Ser Gln Ser Asn Cys Gln Gln Phe Leu Asn Thr Val Trp Phe Gly Gln 
    290                 295                 300                 


Met Ser Gly Tyr Arg Arg Lys Pro Thr Cys Lys Lys Ile Met Thr Val 
305                 310                 315                 320 


Leu Thr Val Gly Ile Phe Trp Pro Val Leu Ser Leu Cys Tyr Leu Ile 
                325                 330                 335     


Ala Pro Lys Ser Gln Phe Gly Arg Ile Ile His Thr Pro Phe Met Lys 
            340                 345                 350         


Phe Ile Ile His Gly Ala Ser Tyr Phe Thr Phe Leu Leu Leu Leu Asn 
        355                 360                 365             


Leu Tyr Ser Leu Val Tyr Asn Glu Asp Lys Lys Asn Thr Met Gly Pro 
    370                 375                 380                 


Ala Leu Glu Arg Ile Asp Tyr Leu Leu Ile Leu Trp Ile Ile Gly Met 
385                 390                 395                 400 


Ile Trp Ser Asp Ile Lys Arg Leu Trp Tyr Glu Gly Leu Glu Asp Phe 
                405                 410                 415     


Leu Glu Glu Ser Arg Asn Gln Leu Ser Phe Val Met Asn Ser Leu Tyr 
            420                 425                 430         


Leu Ala Thr Phe Ala Leu Lys Val Val Ala His Asn Lys Phe His Asp 
        435                 440                 445             


Phe Ala Asp Arg Lys Asp Trp Asp Ala Phe His Pro Thr Leu Val Ala 
    450                 455                 460                 


Glu Gly Leu Phe Ala Phe Ala Asn Val Leu Ser Tyr Leu Arg Leu Phe 
465                 470                 475                 480 


Phe Met Tyr Thr Thr Ser Ser Ile Leu Gly Pro Leu Gln Ile Ser Met 
                485                 490                 495     


Gly Gln Met Leu Gln Asp Phe Gly Lys Phe Leu Gly Met Phe Leu Leu 
            500                 505                 510         


Val Leu Phe Ser Phe Thr Ile Gly Leu Thr Gln Leu Tyr Asp Lys Gly 
        515                 520                 525             


Tyr Thr Ser Lys Glu Gln Lys Asp Cys Val Gly Ile Phe Cys Glu Gln 
    530                 535                 540                 


Gln Ser Asn Asp Thr Phe His Ser Phe Ile Gly Thr Cys Phe Ala Leu 
545                 550                 555                 560 


Phe Trp Tyr Ile Phe Ser Leu Ala His Val Ala Ile Phe Val Thr Arg 
                565                 570                 575     


Phe Ser Tyr Gly Glu Glu Leu Gln Ser Phe Val Gly Ala Val Ile Val 
            580                 585                 590         


Gly Thr Tyr Asn Val Val Val Val Ile Val Leu Thr Lys Leu Leu Val 
        595                 600                 605             


Ala Met Leu His Lys Ser Phe Gln Leu Ile Ala Asn His Glu Asp Lys 
    610                 615                 620                 


Glu Trp Lys Phe Ala Arg Ala Lys Leu Trp Leu Ser Tyr Phe Asp Asp 
625                 630                 635                 640 


Lys Cys Thr Leu Pro Pro Pro Phe Asn Ile Ile Pro Ser Pro Lys Thr 
                645                 650                 655     


Ile Cys Tyr Met Ile Ser Ser Leu Ser Lys Trp Ile Cys Ser His Thr 
            660                 665                 670         


Ser Lys Gly Lys Val Lys Arg Gln Asn Ser Leu Lys Glu Trp Arg Asn 
        675                 680                 685             


Leu Lys Gln Lys Arg Asp Glu Asn Tyr Gln Lys Val Met Cys Cys Leu 
    690                 695                 700                 


Val His Arg Tyr Leu Thr Ser Met Arg Gln Lys Met Gln Ser Thr Asp 
705                 710                 715                 720 


Gln Ala Thr Val Glu Asn Leu Asn Glu Leu Arg Gln Asp Leu Ser Lys 
                725                 730                 735     


Phe Arg Asn Glu Ile Arg Asp Leu Leu Gly Phe Arg Thr Ser Lys Tyr 
            740                 745                 750         


Ala Met Phe Tyr Pro Arg Asn 
        755                 


<210>  2818
<211>  848
<212>  PRT
<213>  Homo sapiens

<400>  2818

Met Glu Gly Ser Pro Ser Leu Arg Arg Met Thr Val Met Arg Glu Lys 
1               5                   10                  15      


Gly Arg Arg Gln Ala Val Arg Gly Pro Ala Phe Met Phe Asn Asp Arg 
            20                  25                  30          


Gly Thr Ser Leu Thr Ala Glu Glu Glu Arg Phe Leu Asp Ala Ala Glu 
        35                  40                  45              


Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu Glu Glu Ser Lys Thr 
    50                  55                  60                  


Leu Asn Val Asn Cys Val Asp Tyr Met Gly Gln Asn Ala Leu Gln Leu 
65                  70                  75                  80  


Ala Val Gly Asn Glu His Leu Glu Val Thr Glu Leu Leu Leu Lys Lys 
                85                  90                  95      


Glu Asn Leu Ala Arg Ile Gly Asp Ala Leu Leu Leu Ala Ile Ser Lys 
            100                 105                 110         


Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Asn His Pro Gly Phe Ala 
        115                 120                 125             


Ala Ser Lys Arg Leu Thr Leu Ser Pro Cys Glu Gln Glu Leu Gln Asp 
    130                 135                 140                 


Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr Arg Phe Ser Pro Asp 
145                 150                 155                 160 


Ile Thr Pro Ile Ile Leu Ala Ala His Cys Gln Lys Tyr Glu Val Val 
                165                 170                 175     


His Met Leu Leu Met Lys Gly Ala Arg Ile Glu Arg Pro His Asp Tyr 
            180                 185                 190         


Phe Cys Lys Cys Gly Asp Cys Met Glu Lys Gln Arg His Asp Ser Phe 
        195                 200                 205             


Ser His Ser Arg Ser Arg Ile Asn Ala Tyr Lys Gly Leu Ala Ser Pro 
    210                 215                 220                 


Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val Leu Thr Ala Leu Glu 
225                 230                 235                 240 


Leu Ser Asn Glu Leu Ala Lys Leu Ala Asn Ile Glu Lys Glu Phe Lys 
                245                 250                 255     


Asn Asp Tyr Arg Lys Leu Ser Met Gln Cys Lys Asp Phe Val Val Gly 
            260                 265                 270         


Val Leu Asp Leu Cys Arg Asp Ser Glu Glu Val Glu Ala Ile Leu Asn 
        275                 280                 285             


Gly Asp Leu Glu Ser Ala Glu Pro Leu Glu Val His Arg His Lys Ala 
    290                 295                 300                 


Ser Leu Ser Arg Val Lys Leu Ala Ile Lys Tyr Glu Val Lys Lys Phe 
305                 310                 315                 320 


Val Ala His Pro Asn Cys Gln Gln Gln Leu Leu Thr Ile Trp Tyr Glu 
                325                 330                 335     


Asn Leu Ser Gly Leu Arg Glu Gln Thr Ile Ala Ile Lys Cys Leu Val 
            340                 345                 350         


Val Leu Val Val Ala Leu Gly Leu Pro Phe Leu Ala Ile Gly Tyr Trp 
        355                 360                 365             


Ile Ala Pro Cys Ser Arg Leu Gly Lys Ile Leu Arg Ser Pro Phe Met 
    370                 375                 380                 


Lys Phe Val Ala His Ala Ala Ser Phe Ile Ile Phe Leu Gly Leu Leu 
385                 390                 395                 400 


Val Phe Asn Ala Ser Asp Arg Phe Glu Gly Ile Thr Thr Leu Pro Asn 
                405                 410                 415     


Ile Thr Val Thr Asp Tyr Pro Lys Gln Ile Phe Arg Val Lys Thr Thr 
            420                 425                 430         


Gln Phe Thr Trp Thr Glu Met Leu Ile Met Val Trp Val Leu Gly Met 
        435                 440                 445             


Met Trp Ser Glu Cys Lys Glu Leu Trp Leu Glu Gly Pro Arg Glu Tyr 
    450                 455                 460                 


Ile Leu Gln Leu Trp Asn Val Leu Asp Phe Gly Met Leu Ser Ile Phe 
465                 470                 475                 480 


Ile Ala Ala Phe Thr Ala Arg Phe Leu Ala Phe Leu Gln Ala Thr Lys 
                485                 490                 495     


Ala Gln Gln Tyr Val Asp Ser Tyr Val Gln Glu Ser Asp Leu Ser Glu 
            500                 505                 510         


Val Thr Leu Pro Pro Glu Ile Gln Tyr Phe Thr Tyr Ala Arg Asp Lys 
        515                 520                 525             


Trp Leu Pro Ser Asp Pro Gln Ile Ile Ser Glu Gly Leu Tyr Ala Ile 
    530                 535                 540                 


Ala Val Val Leu Ser Phe Ser Arg Ile Ala Tyr Ile Leu Pro Ala Asn 
545                 550                 555                 560 


Glu Ser Phe Gly Pro Leu Gln Ile Ser Leu Gly Arg Thr Val Lys Asp 
                565                 570                 575     


Ile Phe Lys Phe Met Val Leu Phe Ile Met Val Phe Phe Ala Phe Met 
            580                 585                 590         


Ile Gly Met Phe Ile Leu Tyr Ser Tyr Tyr Leu Gly Ala Lys Val Asn 
        595                 600                 605             


Ala Ala Phe Thr Thr Val Glu Glu Ser Phe Lys Thr Leu Phe Trp Ser 
    610                 615                 620                 


Ile Phe Gly Leu Ser Glu Val Thr Ser Val Val Leu Lys Tyr Asp His 
625                 630                 635                 640 


Lys Phe Ile Glu Asn Ile Gly Tyr Val Leu Tyr Gly Ile Tyr Asn Val 
                645                 650                 655     


Thr Met Val Val Val Leu Leu Asn Met Leu Ile Ala Met Ile Asn Ser 
            660                 665                 670         


Ser Tyr Gln Glu Ile Glu Asp Asp Ser Asp Val Glu Trp Lys Phe Ala 
        675                 680                 685             


Arg Ser Lys Leu Trp Leu Ser Tyr Phe Asp Asp Gly Lys Thr Leu Pro 
    690                 695                 700                 


Pro Pro Phe Ser Leu Val Pro Ser Pro Lys Ser Phe Val Tyr Phe Ile 
705                 710                 715                 720 


Met Arg Ile Val Asn Phe Pro Lys Cys Arg Arg Arg Arg Leu Gln Lys 
                725                 730                 735     


Asp Ile Glu Met Gly Met Gly Asn Ser Lys Ser Arg Leu Asn Leu Phe 
            740                 745                 750         


Thr Gln Ser Asn Ser Arg Val Phe Glu Ser His Ser Phe Asn Ser Ile 
        755                 760                 765             


Leu Asn Gln Pro Thr Arg Tyr Gln Gln Ile Met Lys Arg Leu Ile Lys 
    770                 775                 780                 


Arg Tyr Val Leu Lys Ala Gln Val Asp Lys Glu Asn Asp Glu Val Asn 
785                 790                 795                 800 


Glu Gly Glu Leu Lys Glu Ile Lys Gln Asp Ile Ser Ser Leu Arg Tyr 
                805                 810                 815     


Glu Leu Leu Glu Asp Lys Ser Gln Ala Thr Glu Glu Leu Ala Ile Leu 
            820                 825                 830         


Ile His Lys Leu Ser Glu Lys Leu Asn Pro Ser Met Leu Arg Cys Glu 
        835                 840                 845             


<210>  2819
<211>  982
<212>  PRT
<213>  Homo sapiens

<400>  2819

Met Ala Gln Phe Tyr Tyr Lys Arg Asn Val Asn Ala Pro Tyr Arg Asp 
1               5                   10                  15      


Arg Ile Pro Leu Arg Ile Val Arg Ala Glu Ser Glu Leu Ser Pro Ser 
            20                  25                  30          


Glu Lys Ala Tyr Leu Asn Ala Val Glu Lys Gly Asp Tyr Ala Ser Val 
        35                  40                  45              


Lys Lys Ser Leu Glu Glu Ala Glu Ile Tyr Phe Lys Ile Asn Ile Asn 
    50                  55                  60                  


Cys Ile Asp Pro Leu Gly Arg Thr Ala Leu Leu Ile Ala Ile Glu Asn 
65                  70                  75                  80  


Glu Asn Leu Glu Leu Ile Glu Leu Leu Leu Ser Phe Asn Val Tyr Val 
                85                  90                  95      


Gly Asp Ala Leu Leu His Ala Ile Arg Lys Glu Val Val Gly Ala Val 
            100                 105                 110         


Glu Leu Leu Leu Asn His Lys Lys Pro Ser Gly Glu Lys Gln Val Pro 
        115                 120                 125             


Pro Ile Leu Leu Asp Lys Gln Phe Ser Glu Phe Thr Pro Asp Ile Thr 
    130                 135                 140                 


Pro Ile Ile Leu Ala Ala His Thr Asn Asn Tyr Glu Ile Ile Lys Leu 
145                 150                 155                 160 


Leu Val Gln Lys Gly Val Ser Val Pro Arg Pro His Glu Val Arg Cys 
                165                 170                 175     


Asn Cys Val Glu Cys Val Ser Ser Ser Asp Val Asp Ser Leu Arg His 
            180                 185                 190         


Ser Arg Ser Arg Leu Asn Ile Tyr Lys Ala Leu Ala Ser Pro Ser Leu 
        195                 200                 205             


Ile Ala Leu Ser Ser Glu Asp Pro Phe Leu Thr Ala Phe Gln Leu Ser 
    210                 215                 220                 


Trp Glu Leu Gln Glu Leu Ser Lys Val Glu Asn Glu Phe Lys Ser Glu 
225                 230                 235                 240 


Tyr Glu Glu Leu Ser Arg Gln Cys Lys Gln Phe Ala Lys Asp Leu Leu 
                245                 250                 255     


Asp Gln Thr Arg Ser Ser Arg Glu Leu Glu Ile Ile Leu Asn Tyr Arg 
            260                 265                 270         


Asp Asp Asn Ser Leu Ile Glu Glu Gln Ser Gly Asn Asp Leu Ala Arg 
        275                 280                 285             


Leu Lys Leu Ala Ile Lys Tyr Arg Gln Lys Glu Phe Val Ala Gln Pro 
    290                 295                 300                 


Asn Cys Gln Gln Leu Leu Ala Ser Arg Trp Tyr Asp Glu Phe Pro Gly 
305                 310                 315                 320 


Trp Arg Arg Arg His Trp Ala Val Lys Met Val Thr Cys Phe Ile Ile 
                325                 330                 335     


Gly Leu Leu Phe Pro Val Phe Ser Val Cys Tyr Leu Ile Ala Pro Lys 
            340                 345                 350         


Ser Pro Leu Gly Leu Phe Ile Arg Lys Pro Phe Ile Lys Phe Ile Cys 
        355                 360                 365             


His Thr Ala Ser Tyr Leu Thr Phe Leu Phe Leu Leu Leu Leu Ala Ser 
    370                 375                 380                 


Gln His Ile Asp Arg Ser Asp Leu Asn Arg Gln Gly Pro Pro Pro Thr 
385                 390                 395                 400 


Ile Val Glu Trp Met Ile Leu Pro Trp Val Leu Gly Phe Ile Trp Gly 
                405                 410                 415     


Glu Ile Lys Gln Met Trp Asp Gly Gly Leu Gln Asp Tyr Ile His Asp 
            420                 425                 430         


Trp Trp Asn Leu Met Asp Phe Val Met Asn Ser Leu Tyr Leu Ala Thr 
        435                 440                 445             


Ile Ser Leu Lys Ile Val Ala Phe Val Lys Tyr Ser Ala Leu Asn Pro 
    450                 455                 460                 


Arg Glu Ser Trp Asp Met Trp His Pro Thr Leu Val Ala Glu Ala Leu 
465                 470                 475                 480 


Phe Ala Ile Ala Asn Ile Phe Ser Ser Leu Arg Leu Ile Ser Leu Phe 
                485                 490                 495     


Thr Ala Asn Ser His Leu Gly Pro Leu Gln Ile Ser Leu Gly Arg Met 
            500                 505                 510         


Leu Leu Asp Ile Leu Lys Phe Leu Phe Ile Tyr Cys Leu Val Leu Leu 
        515                 520                 525             


Ala Phe Ala Asn Gly Leu Asn Gln Leu Tyr Phe Tyr Tyr Glu Glu Thr 
    530                 535                 540                 


Lys Gly Leu Thr Cys Lys Gly Ile Arg Cys Glu Lys Gln Asn Asn Ala 
545                 550                 555                 560 


Phe Ser Thr Leu Phe Glu Thr Leu Gln Ser Leu Phe Trp Ser Ile Phe 
                565                 570                 575     


Gly Leu Ile Asn Leu Tyr Val Thr Asn Val Lys Ala Gln His Glu Phe 
            580                 585                 590         


Thr Glu Phe Val Gly Ala Thr Met Phe Gly Thr Tyr Asn Val Ile Ser 
        595                 600                 605             


Leu Val Val Leu Leu Asn Met Leu Ile Ala Met Met Asn Asn Ser Tyr 
    610                 615                 620                 


Gln Leu Ile Ala Asp His Ala Asp Ile Glu Trp Lys Phe Ala Arg Thr 
625                 630                 635                 640 


Lys Leu Trp Met Ser Tyr Phe Glu Glu Gly Gly Thr Leu Pro Thr Pro 
                645                 650                 655     


Phe Asn Val Ile Pro Ser Pro Lys Ser Leu Trp Tyr Leu Ile Lys Trp 
            660                 665                 670         


Ile Trp Thr His Leu Cys Lys Lys Lys Met Arg Arg Lys Pro Glu Ser 
        675                 680                 685             


Phe Gly Thr Ile Gly Val Arg Thr Gln His Arg Arg Ala Ala Asp Asn 
    690                 695                 700                 


Leu Arg Arg His His Gln Tyr Gln Glu Val Met Arg Asn Leu Val Lys 
705                 710                 715                 720 


Arg Tyr Val Ala Ala Met Ile Arg Asp Ala Lys Thr Glu Glu Gly Leu 
                725                 730                 735     


Thr Glu Glu Asn Phe Lys Glu Leu Lys Gln Asp Ile Ser Ser Phe Arg 
            740                 745                 750         


Phe Glu Val Leu Gly Leu Leu Arg Gly Ser Lys Leu Ser Thr Ile Gln 
        755                 760                 765             


Ser Ala Asn Ala Ser Lys Glu Ser Ser Asn Ser Ala Asp Ser Asp Glu 
    770                 775                 780                 


Lys Ser Asp Ser Glu Gly Asn Ser Lys Asp Lys Lys Lys Asn Phe Ser 
785                 790                 795                 800 


Leu Phe Asp Leu Thr Thr Leu Ile His Pro Arg Ser Ala Ala Ile Ala 
                805                 810                 815     


Ser Glu Arg His Asn Ile Ser Asn Gly Ser Ala Leu Val Val Gln Glu 
            820                 825                 830         


Pro Pro Arg Glu Lys Gln Arg Lys Val Asn Phe Val Thr Asp Ile Lys 
        835                 840                 845             


Asn Phe Gly Leu Phe His Arg Arg Ser Lys Gln Asn Ala Ala Glu Gln 
    850                 855                 860                 


Asn Ala Asn Gln Ile Phe Ser Val Ser Glu Glu Val Ala Arg Gln Gln 
865                 870                 875                 880 


Ala Ala Gly Pro Leu Glu Arg Asn Ile Gln Leu Glu Ser Arg Gly Leu 
                885                 890                 895     


Ala Ser Arg Gly Asp Leu Ser Ile Pro Gly Leu Ser Glu Gln Cys Val 
            900                 905                 910         


Leu Val Asp His Arg Glu Arg Asn Thr Asp Thr Leu Gly Leu Gln Val 
        915                 920                 925             


Gly Lys Arg Val Cys Pro Phe Lys Ser Glu Lys Val Val Val Glu Asp 
    930                 935                 940                 


Thr Val Pro Ile Ile Pro Lys Glu Lys His Ala Lys Glu Glu Asp Ser 
945                 950                 955                 960 


Ser Ile Asp Tyr Asp Leu Asn Leu Pro Asp Thr Val Thr His Glu Asp 
                965                 970                 975     


Tyr Val Thr Thr Arg Leu 
            980         


<210>  2820
<211>  1503
<212>  PRT
<213>  Homo sapiens

<400>  2820

Met Glu Pro Ser Ala Leu Arg Lys Ala Gly Ser Glu Gln Glu Glu Gly 
1               5                   10                  15      


Phe Glu Gly Leu Pro Arg Arg Val Thr Asp Leu Gly Met Val Ser Asn 
            20                  25                  30          


Leu Arg Arg Ser Asn Ser Ser Leu Phe Lys Ser Trp Arg Leu Gln Cys 
        35                  40                  45              


Pro Phe Gly Asn Asn Asp Lys Gln Glu Ser Leu Ser Ser Trp Ile Pro 
    50                  55                  60                  


Glu Asn Ile Lys Lys Lys Glu Cys Val Tyr Phe Val Glu Ser Ser Lys 
65                  70                  75                  80  


Leu Ser Asp Ala Gly Lys Val Val Cys Gln Cys Gly Tyr Thr His Glu 
                85                  90                  95      


Gln His Leu Glu Glu Ala Thr Lys Pro His Thr Phe Gln Gly Thr Gln 
            100                 105                 110         


Trp Asp Pro Lys Lys His Val Gln Glu Met Pro Thr Asp Ala Phe Gly 
        115                 120                 125             


Asp Ile Val Phe Thr Gly Leu Ser Gln Lys Val Lys Lys Tyr Val Arg 
    130                 135                 140                 


Val Ser Gln Asp Thr Pro Ser Ser Val Ile Tyr His Leu Met Thr Gln 
145                 150                 155                 160 


His Trp Gly Leu Asp Val Pro Asn Leu Leu Ile Ser Val Thr Gly Gly 
                165                 170                 175     


Ala Lys Asn Phe Asn Met Lys Pro Arg Leu Lys Ser Ile Phe Arg Arg 
            180                 185                 190         


Gly Leu Val Lys Val Ala Gln Thr Thr Gly Ala Trp Ile Ile Thr Gly 
        195                 200                 205             


Gly Ser His Thr Gly Val Met Lys Gln Val Gly Glu Ala Val Arg Asp 
    210                 215                 220                 


Phe Ser Leu Ser Ser Ser Tyr Lys Glu Gly Glu Leu Ile Thr Ile Gly 
225                 230                 235                 240 


Val Ala Thr Trp Gly Thr Val His Arg Arg Glu Gly Leu Ile His Pro 
                245                 250                 255     


Thr Gly Ser Phe Pro Ala Glu Tyr Ile Leu Asp Glu Asp Gly Gln Gly 
            260                 265                 270         


Asn Leu Thr Cys Leu Asp Ser Asn His Ser His Phe Ile Leu Val Asp 
        275                 280                 285             


Asp Gly Thr His Gly Gln Tyr Gly Val Glu Ile Pro Leu Arg Thr Arg 
    290                 295                 300                 


Leu Glu Lys Phe Ile Ser Glu Gln Thr Lys Glu Arg Gly Gly Val Ala 
305                 310                 315                 320 


Ile Lys Ile Pro Ile Val Cys Val Val Leu Glu Gly Gly Pro Gly Thr 
                325                 330                 335     


Leu His Thr Ile Asp Asn Ala Thr Thr Asn Gly Thr Pro Cys Val Val 
            340                 345                 350         


Val Glu Gly Ser Gly Arg Val Ala Asp Val Ile Ala Gln Val Ala Asn 
        355                 360                 365             


Leu Pro Val Ser Asp Ile Thr Ile Ser Leu Ile Gln Gln Lys Leu Ser 
    370                 375                 380                 


Val Phe Phe Gln Glu Met Phe Glu Thr Phe Thr Glu Ser Arg Ile Val 
385                 390                 395                 400 


Glu Trp Thr Lys Lys Ile Gln Asp Ile Val Arg Arg Arg Gln Leu Leu 
                405                 410                 415     


Thr Val Phe Arg Glu Gly Lys Asp Gly Gln Gln Asp Val Asp Val Ala 
            420                 425                 430         


Ile Leu Gln Ala Leu Leu Lys Ala Ser Arg Ser Gln Asp His Phe Gly 
        435                 440                 445             


His Glu Asn Trp Asp His Gln Leu Lys Leu Ala Val Ala Trp Asn Arg 
    450                 455                 460                 


Val Asp Ile Ala Arg Ser Glu Ile Phe Met Asp Glu Trp Gln Trp Lys 
465                 470                 475                 480 


Pro Ser Asp Leu His Pro Thr Met Thr Ala Ala Leu Ile Ser Asn Lys 
                485                 490                 495     


Pro Glu Phe Val Lys Leu Phe Leu Glu Asn Gly Val Gln Leu Lys Glu 
            500                 505                 510         


Phe Val Thr Trp Asp Thr Leu Leu Tyr Leu Tyr Glu Asn Leu Asp Pro 
        515                 520                 525             


Ser Cys Leu Phe His Ser Lys Leu Gln Lys Val Leu Val Glu Asp Pro 
    530                 535                 540                 


Glu Arg Pro Ala Cys Ala Pro Ala Ala Pro Arg Leu Gln Met His His 
545                 550                 555                 560 


Val Ala Gln Val Leu Arg Glu Leu Leu Gly Asp Phe Thr Gln Pro Leu 
                565                 570                 575     


Tyr Pro Arg Pro Arg His Asn Asp Arg Leu Arg Leu Leu Leu Pro Val 
            580                 585                 590         


Pro His Val Lys Leu Asn Val Gln Gly Val Ser Leu Arg Ser Leu Tyr 
        595                 600                 605             


Lys Arg Ser Ser Gly His Val Thr Phe Thr Met Asp Pro Ile Arg Asp 
    610                 615                 620                 


Leu Leu Ile Trp Ala Ile Val Gln Asn Arg Arg Glu Leu Ala Gly Ile 
625                 630                 635                 640 


Ile Trp Ala Gln Ser Gln Asp Cys Ile Ala Ala Ala Leu Ala Cys Ser 
                645                 650                 655     


Lys Ile Leu Lys Glu Leu Ser Lys Glu Glu Glu Asp Thr Asp Ser Ser 
            660                 665                 670         


Glu Glu Met Leu Ala Leu Ala Glu Glu Tyr Glu His Arg Ala Ile Gly 
        675                 680                 685             


Val Phe Thr Glu Cys Tyr Arg Lys Asp Glu Glu Arg Ala Gln Lys Leu 
    690                 695                 700                 


Leu Thr Arg Val Ser Glu Ala Trp Gly Lys Thr Thr Cys Leu Gln Leu 
705                 710                 715                 720 


Ala Leu Glu Ala Lys Asp Met Lys Phe Val Ser His Gly Gly Ile Gln 
                725                 730                 735     


Ala Phe Leu Thr Lys Val Trp Trp Gly Gln Leu Ser Val Asp Asn Gly 
            740                 745                 750         


Leu Trp Arg Val Thr Leu Cys Met Leu Ala Phe Pro Leu Leu Leu Thr 
        755                 760                 765             


Gly Leu Ile Ser Phe Arg Glu Lys Arg Leu Gln Asp Val Gly Thr Pro 
    770                 775                 780                 


Ala Ala Arg Ala Arg Ala Phe Phe Thr Ala Pro Val Val Val Phe His 
785                 790                 795                 800 


Leu Asn Ile Leu Ser Tyr Phe Ala Phe Leu Cys Leu Phe Ala Tyr Val 
                805                 810                 815     


Leu Met Val Asp Phe Gln Pro Val Pro Ser Trp Cys Glu Cys Ala Ile 
            820                 825                 830         


Tyr Leu Trp Leu Phe Ser Leu Val Cys Glu Glu Met Arg Gln Leu Phe 
        835                 840                 845             


Tyr Asp Pro Asp Glu Cys Gly Leu Met Lys Lys Ala Ala Leu Tyr Phe 
    850                 855                 860                 


Ser Asp Phe Trp Asn Lys Leu Asp Val Gly Ala Ile Leu Leu Phe Val 
865                 870                 875                 880 


Ala Gly Leu Thr Cys Arg Leu Ile Pro Ala Thr Leu Tyr Pro Gly Arg 
                885                 890                 895     


Val Ile Leu Ser Leu Asp Phe Ile Leu Phe Cys Leu Arg Leu Met His 
            900                 905                 910         


Ile Phe Thr Ile Ser Lys Thr Leu Gly Pro Lys Ile Ile Ile Val Lys 
        915                 920                 925             


Arg Met Met Lys Asp Val Phe Phe Phe Leu Phe Leu Leu Ala Val Trp 
    930                 935                 940                 


Val Val Ser Phe Gly Val Ala Lys Gln Ala Ile Leu Ile His Asn Glu 
945                 950                 955                 960 


Arg Arg Val Asp Trp Leu Phe Arg Gly Ala Val Tyr His Ser Tyr Leu 
                965                 970                 975     


Thr Ile Phe Gly Gln Ile Pro Gly Tyr Ile Asp Gly Val Asn Phe Asn 
            980                 985                 990         


Pro Glu His Cys Ser Pro Asn Gly  Thr Asp Pro Tyr Lys  Pro Lys Cys 
        995                 1000                 1005             


Pro Glu  Ser Asp Ala Thr Gln  Gln Arg Pro Ala Phe  Pro Glu Trp 
    1010                 1015                 1020             


Leu Thr  Val Leu Leu Leu Cys  Leu Tyr Leu Leu Phe  Thr Asn Ile 
    1025                 1030                 1035             


Leu Leu  Leu Asn Leu Leu Ile  Ala Met Phe Asn Tyr  Thr Phe Gln 
    1040                 1045                 1050             


Gln Val  Gln Glu His Thr Asp  Gln Ile Trp Lys Phe  Gln Arg His 
    1055                 1060                 1065             


Asp Leu  Ile Glu Glu Tyr His  Gly Arg Pro Ala Ala  Pro Pro Pro 
    1070                 1075                 1080             


Phe Ile  Leu Leu Ser His Leu  Gln Leu Phe Ile Lys  Arg Val Val 
    1085                 1090                 1095             


Leu Lys  Thr Pro Ala Lys Arg  His Lys Gln Leu Lys  Asn Lys Leu 
    1100                 1105                 1110             


Glu Lys  Asn Glu Glu Ala Ala  Leu Leu Ser Trp Glu  Ile Tyr Leu 
    1115                 1120                 1125             


Lys Glu  Asn Tyr Leu Gln Asn  Arg Gln Phe Gln Gln  Lys Gln Arg 
    1130                 1135                 1140             


Pro Glu  Gln Lys Ile Glu Asp  Ile Ser Asn Lys Val  Asp Ala Met 
    1145                 1150                 1155             


Val Asp  Leu Leu Asp Leu Asp  Pro Leu Lys Arg Ser  Gly Ser Met 
    1160                 1165                 1170             


Glu Gln  Arg Leu Ala Ser Leu  Glu Glu Gln Val Ala  Gln Thr Ala 
    1175                 1180                 1185             


Arg Ala  Leu His Trp Ile Val  Arg Thr Leu Arg Ala  Ser Gly Phe 
    1190                 1195                 1200             


Ser Ser  Glu Ala Asp Val Pro  Thr Leu Ala Ser Gln  Lys Ala Ala 
    1205                 1210                 1215             


Glu Glu  Pro Asp Ala Glu Pro  Gly Gly Arg Lys Lys  Thr Glu Glu 
    1220                 1225                 1230             


Pro Gly  Asp Ser Tyr His Val  Asn Ala Arg His Leu  Leu Tyr Pro 
    1235                 1240                 1245             


Asn Cys  Pro Val Thr Arg Phe  Pro Val Pro Asn Glu  Lys Val Pro 
    1250                 1255                 1260             


Trp Glu  Thr Glu Phe Leu Ile  Tyr Asp Pro Pro Phe  Tyr Thr Ala 
    1265                 1270                 1275             


Glu Arg  Lys Asp Ala Ala Ala  Met Asp Pro Met Gly  Asp Thr Leu 
    1280                 1285                 1290             


Glu Pro  Leu Ser Thr Ile Gln  Tyr Asn Val Val Asp  Gly Leu Arg 
    1295                 1300                 1305             


Asp Arg  Arg Ser Phe His Gly  Pro Tyr Thr Val Gln  Ala Gly Leu 
    1310                 1315                 1320             


Pro Leu  Asn Pro Met Gly Arg  Thr Gly Leu Arg Gly  Arg Gly Ser 
    1325                 1330                 1335             


Leu Ser  Cys Phe Gly Pro Asn  His Thr Leu Tyr Pro  Met Val Thr 
    1340                 1345                 1350             


Arg Trp  Arg Arg Asn Glu Asp  Gly Ala Ile Cys Arg  Lys Ser Ile 
    1355                 1360                 1365             


Lys Lys  Met Leu Glu Val Leu  Val Val Lys Leu Pro  Leu Ser Glu 
    1370                 1375                 1380             


His Trp  Ala Leu Pro Gly Gly  Ser Arg Glu Pro Gly  Glu Met Leu 
    1385                 1390                 1395             


Pro Arg  Lys Leu Lys Arg Ile  Leu Arg Gln Glu His  Trp Pro Ser 
    1400                 1405                 1410             


Phe Glu  Asn Leu Leu Lys Cys  Gly Met Glu Val Tyr  Lys Gly Tyr 
    1415                 1420                 1425             


Met Asp  Asp Pro Arg Asn Thr  Asp Asn Ala Trp Ile  Glu Thr Val 
    1430                 1435                 1440             


Ala Val  Ser Val His Phe Gln  Asp Gln Asn Asp Val  Glu Leu Asn 
    1445                 1450                 1455             


Arg Leu  Asn Ser Asn Leu His  Ala Cys Asp Ser Gly  Ala Ser Ile 
    1460                 1465                 1470             


Arg Trp  Gln Val Val Asp Arg  Arg Ile Pro Leu Tyr  Ala Asn His 
    1475                 1480                 1485             


Lys Thr  Leu Leu Gln Lys Ala  Ala Ala Glu Phe Gly  Ala His Tyr 
    1490                 1495                 1500             


<210>  2821
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  2821

Met Glu Arg Val Gln Pro Leu Glu Glu Asn Val Gly Asn Ala Ala Arg 
1               5                   10                  15      


Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu Val Ala Ser Val Ile Gln 
            20                  25                  30          


Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu His Phe Ser 
        35                  40                  45              


Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val 
    50                  55                  60                  


Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln 
65                  70                  75                  80  


Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn 
                85                  90                  95      


Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu 
            100                 105                 110         


Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln 
        115                 120                 125             


Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr 
    130                 135                 140                 


Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu 
145                 150                 155                 160 


Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn 
                165                 170                 175     


Pro Gly Glu Phe Cys Val Leu 
            180             


<210>  2822
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  2822

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  


Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
225                 230                 235                 240 


Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
                245                 250                 255     


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            260                 265                 270         


Thr Leu Ala Lys Ile 
        275         


<210>  2823
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  2823

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Gly Leu Arg Pro Val Gln Ala Gln Ala Gln Ser Asp 
            20                  25                  30          


Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly Ile Val Met 
        35                  40                  45              


Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu 
    50                  55                  60                  


Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg 
65                  70                  75                  80  


Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly 
                85                  90                  95      


Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr 
            100                 105                 110         


Lys 
    


<210>  2824
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  2824

Met Ala Gly Ala Glu Asp Trp Pro Gly Gln Gln Leu Glu Leu Asp Glu 
1               5                   10                  15      


Asp Glu Ala Ser Cys Cys Arg Trp Gly Ala Gln His Ala Gly Ala Arg 
            20                  25                  30          


Glu Leu Ala Ala Leu Tyr Ser Pro Gly Lys Arg Leu Gln Glu Trp Cys 
        35                  40                  45              


Ser Val Ile Leu Cys Phe Ser Leu Ile Ala His Asn Leu Val His Leu 
    50                  55                  60                  


Leu Leu Leu Ala Arg Trp Glu Asp Thr Pro Leu Val Ile Leu Gly Val 
65                  70                  75                  80  


Val Ala Gly Ala Leu Ile Ala Asp Phe Leu Ser Gly Leu Val His Trp 
                85                  90                  95      


Gly Ala Asp Thr Trp Gly Ser Val Glu Leu Pro Ile Ala Phe Ile Arg 
            100                 105                 110         


Pro Phe Arg Glu His His Ile Asp Pro Thr Ala Ile Thr Arg His Asp 
        115                 120                 125             


Phe Ile Glu Thr Asn Gly Asp Asn Cys Leu Val Thr Leu Leu Pro Leu 
    130                 135                 140                 


Leu Asn Met Ala Tyr Lys Phe Arg Thr His Ser Pro Glu Ala Leu Glu 
145                 150                 155                 160 


Gln Leu Tyr Pro Trp Glu Cys Phe Val Phe Cys Leu Ile Ile Phe Gly 
                165                 170                 175     


Thr Phe Thr Asn Gln Ile His Lys Trp Ser His Thr Tyr Phe Gly Leu 
            180                 185                 190         


Pro Arg Trp Val Thr Leu Leu Gln Asp Trp His Val Ile Leu Pro Arg 
        195                 200                 205             


Lys His His Arg Ile His His Val Ser Pro His Glu Thr Tyr Phe Cys 
    210                 215                 220                 


Ile Thr Thr Gly Trp Leu Asn Tyr Pro Leu Glu Lys Ile Gly Phe Trp 
225                 230                 235                 240 


Arg Arg Leu Glu Asp Leu Ile Gln Gly Leu Thr Gly Glu Lys Pro Arg 
                245                 250                 255     


Ala Asp Asp Met Lys Trp Ala Gln Lys Ile Lys 
            260                 265         


<210>  2825
<211>  541
<212>  PRT
<213>  Homo sapiens

<400>  2825

Met Lys Ser Tyr Thr Pro Tyr Phe Ile Leu Leu Trp Ser Ala Val Gly 
1               5                   10                  15      


Ile Ala Lys Ala Ala Lys Ile Ile Ile Val Pro Pro Ile Met Phe Glu 
            20                  25                  30          


Ser His Met Tyr Ile Phe Lys Thr Leu Ala Ser Ala Leu His Glu Arg 
        35                  40                  45              


Gly His His Thr Val Phe Leu Leu Ser Glu Gly Arg Asp Ile Ala Pro 
    50                  55                  60                  


Ser Asn His Tyr Ser Leu Gln Arg Tyr Pro Gly Ile Phe Asn Ser Thr 
65                  70                  75                  80  


Thr Ser Asp Ala Phe Leu Gln Ser Lys Met Arg Asn Ile Phe Ser Gly 
                85                  90                  95      


Arg Leu Thr Ala Ile Glu Leu Phe Asp Ile Leu Asp His Tyr Thr Lys 
            100                 105                 110         


Asn Cys Asp Leu Met Val Gly Asn His Ala Leu Ile Gln Gly Leu Lys 
        115                 120                 125             


Lys Glu Lys Phe Asp Leu Leu Leu Val Asp Pro Asn Asp Met Cys Gly 
    130                 135                 140                 


Phe Val Ile Ala His Leu Leu Gly Val Lys Tyr Ala Val Phe Ser Thr 
145                 150                 155                 160 


Gly Leu Trp Tyr Pro Ala Glu Val Gly Ala Pro Ala Pro Leu Ala Tyr 
                165                 170                 175     


Val Pro Glu Phe Asn Ser Leu Leu Thr Asp Arg Met Asn Leu Leu Gln 
            180                 185                 190         


Arg Met Lys Asn Thr Gly Val Tyr Leu Ile Ser Arg Leu Gly Val Ser 
        195                 200                 205             


Phe Leu Val Leu Pro Lys Tyr Glu Arg Ile Met Gln Lys Tyr Asn Leu 
    210                 215                 220                 


Leu Pro Glu Lys Ser Met Tyr Asp Leu Val His Gly Ser Ser Leu Trp 
225                 230                 235                 240 


Met Leu Cys Thr Asp Val Ala Leu Glu Phe Pro Arg Pro Thr Leu Pro 
                245                 250                 255     


Asn Val Val Tyr Val Gly Gly Ile Leu Thr Lys Pro Ala Ser Pro Leu 
            260                 265                 270         


Pro Glu Asp Leu Gln Arg Trp Val Asn Gly Ala Asn Glu His Gly Phe 
        275                 280                 285             


Val Leu Val Ser Phe Gly Ala Gly Val Lys Tyr Leu Ser Glu Asp Ile 
    290                 295                 300                 


Ala Asn Lys Leu Ala Gly Ala Leu Gly Arg Leu Pro Gln Lys Val Ile 
305                 310                 315                 320 


Trp Arg Phe Ser Gly Pro Lys Pro Lys Asn Leu Gly Asn Asn Thr Lys 
                325                 330                 335     


Leu Ile Glu Trp Leu Pro Gln Asn Asp Leu Leu Gly His Ser Lys Ile 
            340                 345                 350         


Lys Ala Phe Leu Ser His Gly Gly Leu Asn Ser Ile Phe Glu Thr Met 
        355                 360                 365             


Tyr His Gly Val Pro Val Val Gly Ile Pro Leu Phe Gly Asp His Tyr 
    370                 375                 380                 


Asp Thr Met Thr Arg Val Gln Ala Lys Gly Met Gly Ile Leu Leu Glu 
385                 390                 395                 400 


Trp Lys Thr Val Thr Glu Lys Glu Leu Tyr Glu Ala Leu Val Lys Val 
                405                 410                 415     


Ile Asn Asn Pro Ser Tyr Arg Gln Arg Ala Gln Lys Leu Ser Glu Ile 
            420                 425                 430         


His Lys Asp Gln Pro Gly His Pro Val Asn Arg Thr Ile Tyr Trp Ile 
        435                 440                 445             


Asp Tyr Ile Ile Arg His Asn Gly Ala His His Leu Arg Ala Ala Val 
    450                 455                 460                 


His Gln Ile Ser Phe Cys Gln Tyr Phe Leu Leu Asp Ile Ala Phe Val 
465                 470                 475                 480 


Leu Leu Leu Gly Ala Ala Leu Leu Tyr Phe Leu Leu Ser Trp Val Thr 
                485                 490                 495     


Lys Phe Ile Tyr Arg Lys Ile Lys Ser Leu Trp Ser Arg Asn Lys His 
            500                 505                 510         


Ser Thr Val Asn Gly His Tyr His Asn Gly Ile Leu Asn Gly Lys Tyr 
        515                 520                 525             


Lys Arg Asn Gly His Ile Lys His Glu Lys Lys Val Lys 
    530                 535                 540     


<210>  2826
<211>  640
<212>  PRT
<213>  Homo sapiens

<400>  2826

Met Gly Gln Pro Ser Leu Thr Trp Met Leu Met Val Val Val Ala Ser 
1               5                   10                  15      


Trp Phe Ile Thr Thr Ala Ala Thr Asp Thr Ser Glu Ala Arg Trp Cys 
            20                  25                  30          


Ser Glu Cys His Ser Asn Ala Thr Cys Thr Glu Asp Glu Ala Val Thr 
        35                  40                  45              


Thr Cys Thr Cys Gln Glu Gly Phe Thr Gly Asp Gly Leu Thr Cys Val 
    50                  55                  60                  


Asp Leu Asp Glu Cys Ala Ile Pro Gly Ala His Asn Cys Ser Ala Asn 
65                  70                  75                  80  


Ser Ser Cys Val Asn Thr Pro Gly Ser Phe Ser Cys Val Cys Pro Glu 
                85                  90                  95      


Gly Phe Arg Leu Ser Pro Gly Leu Gly Cys Thr Asp Val Asp Glu Cys 
            100                 105                 110         


Ala Glu Pro Gly Leu Ser His Cys His Ala Leu Ala Thr Cys Val Asn 
        115                 120                 125             


Val Val Gly Ser Tyr Leu Cys Val Cys Pro Ala Gly Tyr Arg Gly Asp 
    130                 135                 140                 


Gly Trp His Cys Glu Cys Ser Pro Gly Ser Cys Gly Pro Gly Leu Asp 
145                 150                 155                 160 


Cys Val Pro Glu Gly Asp Ala Leu Val Cys Ala Asp Pro Cys Gln Ala 
                165                 170                 175     


His Arg Thr Leu Asp Glu Tyr Trp Arg Ser Thr Glu Tyr Gly Glu Gly 
            180                 185                 190         


Tyr Ala Cys Asp Thr Asp Leu Arg Gly Trp Tyr Arg Phe Val Gly Gln 
        195                 200                 205             


Gly Gly Ala Arg Met Ala Glu Thr Cys Val Pro Val Leu Arg Cys Asn 
    210                 215                 220                 


Thr Ala Ala Pro Met Trp Leu Asn Gly Thr His Pro Ser Ser Asp Glu 
225                 230                 235                 240 


Gly Ile Val Ser Arg Lys Ala Cys Ala His Trp Ser Gly His Cys Cys 
                245                 250                 255     


Leu Trp Asp Ala Ser Val Gln Val Lys Ala Cys Ala Gly Gly Tyr Tyr 
            260                 265                 270         


Val Tyr Asn Leu Thr Ala Pro Pro Glu Cys His Leu Ala Tyr Cys Thr 
        275                 280                 285             


Asp Pro Ser Ser Val Glu Gly Thr Cys Glu Glu Cys Ser Ile Asp Glu 
    290                 295                 300                 


Asp Cys Lys Ser Asn Asn Gly Arg Trp His Cys Gln Cys Lys Gln Asp 
305                 310                 315                 320 


Phe Asn Ile Thr Asp Ile Ser Leu Leu Glu His Arg Leu Glu Cys Gly 
                325                 330                 335     


Ala Asn Asp Met Lys Val Ser Leu Gly Lys Cys Gln Leu Lys Ser Leu 
            340                 345                 350         


Gly Phe Asp Lys Val Phe Met Tyr Leu Ser Asp Ser Arg Cys Ser Gly 
        355                 360                 365             


Phe Asn Asp Arg Asp Asn Arg Asp Trp Val Ser Val Val Thr Pro Ala 
    370                 375                 380                 


Arg Asp Gly Pro Cys Gly Thr Val Leu Thr Arg Asn Glu Thr His Ala 
385                 390                 395                 400 


Thr Tyr Ser Asn Thr Leu Tyr Leu Ala Asp Glu Ile Ile Ile Arg Asp 
                405                 410                 415     


Leu Asn Ile Lys Ile Asn Phe Ala Cys Ser Tyr Pro Leu Asp Met Lys 
            420                 425                 430         


Val Ser Leu Lys Thr Ala Leu Gln Pro Met Val Ser Ala Leu Asn Ile 
        435                 440                 445             


Arg Val Gly Gly Thr Gly Met Phe Thr Val Arg Met Ala Leu Phe Gln 
    450                 455                 460                 


Thr Pro Ser Tyr Thr Gln Pro Tyr Gln Gly Ser Ser Val Thr Leu Ser 
465                 470                 475                 480 


Thr Glu Ala Phe Leu Tyr Val Gly Thr Met Leu Asp Gly Gly Asp Leu 
                485                 490                 495     


Ser Arg Phe Ala Leu Leu Met Thr Asn Cys Tyr Ala Thr Pro Ser Ser 
            500                 505                 510         


Asn Ala Thr Asp Pro Leu Lys Tyr Phe Ile Ile Gln Asp Arg Cys Pro 
        515                 520                 525             


His Thr Arg Asp Ser Thr Ile Gln Val Val Glu Asn Gly Glu Ser Ser 
    530                 535                 540                 


Gln Gly Arg Phe Ser Val Gln Met Phe Arg Phe Ala Gly Asn Tyr Asp 
545                 550                 555                 560 


Leu Val Tyr Leu His Cys Glu Val Tyr Leu Cys Asp Thr Met Asn Glu 
                565                 570                 575     


Lys Cys Lys Pro Thr Cys Ser Gly Thr Arg Phe Arg Ser Gly Ser Val 
            580                 585                 590         


Ile Asp Gln Ser Arg Val Leu Asn Leu Gly Pro Ile Thr Arg Lys Gly 
        595                 600                 605             


Val Gln Ala Thr Val Ser Arg Ala Phe Ser Ser Leu Gly Leu Leu Lys 
    610                 615                 620                 


Val Trp Leu Pro Leu Leu Leu Ser Ala Thr Leu Thr Leu Thr Phe Gln 
625                 630                 635                 640 


<210>  2827
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  2827

Met Asp Thr Arg Asn Lys Ala Gln Leu Leu Val Leu Leu Thr Leu Leu 
1               5                   10                  15      


Ser Val Leu Phe Ser Gln Thr Ser Ala Trp Pro Leu Tyr Arg Ala Pro 
            20                  25                  30          


Ser Ala Leu Arg Leu Gly Asp Arg Ile Pro Phe Glu Gly Ala Asn Glu 
        35                  40                  45              


Pro Asp Gln Val Ser Leu Lys Glu Asp Ile Asp Met Leu Gln Asn Ala 
    50                  55                  60                  


Leu Ala Glu Asn Asp Thr Pro Tyr Tyr Asp Val Ser Arg Asn Ala Arg 
65                  70                  75                  80  


His Ala Asp Gly Val Phe Thr Ser Asp Phe Ser Lys Leu Leu Gly Gln 
                85                  90                  95      


Leu Ser Ala Lys Lys Tyr Leu Glu Ser Leu Met Gly Lys Arg Val Ser 
            100                 105                 110         


Ser Asn Ile Ser Glu Asp Pro Val Pro Val Lys Arg His Ser Asp Ala 
        115                 120                 125             


Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln Met Ala Val Lys 
    130                 135                 140                 


Lys Tyr Leu Asn Ser Ile Leu Asn Gly Lys Arg Ser Ser Glu Gly Glu 
145                 150                 155                 160 


Ser Pro Asp Phe Pro Glu Glu Leu Glu Lys 
                165                 170 


<210>  2828
<211>  438
<212>  PRT
<213>  Homo sapiens

<400>  2828

Met Arg Thr Leu Leu Pro Pro Ala Leu Leu Thr Cys Trp Leu Leu Ala 
1               5                   10                  15      


Pro Val Asn Ser Ile His Pro Glu Cys Arg Phe His Leu Glu Ile Gln 
            20                  25                  30          


Glu Glu Glu Thr Lys Cys Ala Glu Leu Leu Arg Ser Gln Thr Glu Lys 
        35                  40                  45              


His Lys Ala Cys Ser Gly Val Trp Asp Asn Ile Thr Cys Trp Arg Pro 
    50                  55                  60                  


Ala Asn Val Gly Glu Thr Val Thr Val Pro Cys Pro Lys Val Phe Ser 
65                  70                  75                  80  


Asn Phe Tyr Ser Lys Ala Gly Asn Ile Ser Lys Asn Cys Thr Ser Asp 
                85                  90                  95      


Gly Trp Ser Glu Thr Phe Pro Asp Phe Val Asp Ala Cys Gly Tyr Ser 
            100                 105                 110         


Asp Pro Glu Asp Glu Ser Lys Ile Thr Phe Tyr Ile Leu Val Lys Ala 
        115                 120                 125             


Ile Tyr Thr Leu Gly Tyr Ser Val Ser Leu Met Ser Leu Ala Thr Gly 
    130                 135                 140                 


Ser Ile Ile Leu Cys Leu Phe Arg Lys Leu His Cys Thr Arg Asn Tyr 
145                 150                 155                 160 


Ile His Leu Asn Leu Phe Leu Ser Phe Ile Leu Arg Ala Ile Ser Val 
                165                 170                 175     


Leu Val Lys Asp Asp Val Leu Tyr Ser Ser Ser Gly Thr Leu His Cys 
            180                 185                 190         


Pro Asp Gln Pro Ser Ser Trp Val Gly Cys Lys Leu Ser Leu Val Phe 
        195                 200                 205             


Leu Gln Tyr Cys Ile Met Ala Asn Phe Phe Trp Leu Leu Val Glu Gly 
    210                 215                 220                 


Leu Tyr Leu His Thr Leu Leu Val Ala Met Leu Pro Pro Arg Arg Cys 
225                 230                 235                 240 


Phe Leu Ala Tyr Leu Leu Ile Gly Trp Gly Leu Pro Thr Val Cys Ile 
                245                 250                 255     


Gly Ala Trp Thr Ala Ala Arg Leu Tyr Leu Glu Asp Thr Gly Cys Trp 
            260                 265                 270         


Asp Thr Asn Asp His Ser Val Pro Trp Trp Val Ile Arg Ile Pro Ile 
        275                 280                 285             


Leu Ile Ser Ile Ile Val Asn Phe Val Leu Phe Ile Ser Ile Ile Arg 
    290                 295                 300                 


Ile Leu Leu Gln Lys Leu Thr Ser Pro Asp Val Gly Gly Asn Asp Gln 
305                 310                 315                 320 


Ser Gln Tyr Lys Arg Leu Ala Lys Ser Thr Leu Leu Leu Ile Pro Leu 
                325                 330                 335     


Phe Gly Val His Tyr Met Val Phe Ala Val Phe Pro Ile Ser Ile Ser 
            340                 345                 350         


Ser Lys Tyr Gln Ile Leu Phe Glu Leu Cys Leu Gly Ser Phe Gln Gly 
        355                 360                 365             


Leu Val Val Ala Val Leu Tyr Cys Phe Leu Asn Ser Glu Val Gln Cys 
    370                 375                 380                 


Glu Leu Lys Arg Lys Trp Arg Ser Arg Cys Pro Thr Pro Ser Ala Ser 
385                 390                 395                 400 


Arg Asp Tyr Arg Val Cys Gly Ser Ser Phe Ser Arg Asn Gly Ser Glu 
                405                 410                 415     


Gly Ala Leu Gln Phe His Arg Gly Ser Arg Ala Gln Ser Phe Leu Gln 
            420                 425                 430         


Thr Glu Thr Ser Val Ile 
        435             


<210>  2829
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  2829

Met Pro Arg Val Lys Ala Ala Gln Ala Gly Arg Gln Ser Ser Ala Lys 
1               5                   10                  15      


Arg His Leu Ala Glu Gln Phe Ala Val Gly Glu Ile Ile Thr Asp Met 
            20                  25                  30          


Ala Lys Lys Glu Trp Lys Val Gly Leu Pro Ile Gly Gln Gly Gly Phe 
        35                  40                  45              


Gly Cys Ile Tyr Leu Ala Asp Met Asn Ser Ser Glu Ser Val Gly Ser 
    50                  55                  60                  


Asp Ala Pro Cys Val Val Lys Val Glu Pro Ser Asp Asn Gly Pro Leu 
65                  70                  75                  80  


Phe Thr Glu Leu Lys Phe Tyr Gln Arg Ala Ala Lys Pro Glu Gln Ile 
                85                  90                  95      


Gln Lys Trp Ile Arg Thr Arg Lys Leu Lys Tyr Leu Gly Val Pro Lys 
            100                 105                 110         


Tyr Trp Gly Ser Gly Leu His Asp Lys Asn Gly Lys Ser Tyr Arg Phe 
        115                 120                 125             


Met Ile Met Asp Arg Phe Gly Ser Asp Leu Gln Lys Ile Tyr Glu Ala 
    130                 135                 140                 


Asn Ala Lys Arg Phe Ser Arg Lys Thr Val Leu Gln Leu Ser Leu Arg 
145                 150                 155                 160 


Ile Leu Asp Ile Leu Glu Tyr Ile His Glu His Glu Tyr Val His Gly 
                165                 170                 175     


Asp Ile Lys Ala Ser Asn Leu Leu Leu Asn Tyr Lys Asn Pro Asp Gln 
            180                 185                 190         


Val Tyr Leu Val Asp Tyr Gly Leu Ala Tyr Arg Tyr Cys Pro Glu Gly 
        195                 200                 205             


Val His Lys Glu Tyr Lys Glu Asp Pro Lys Arg Cys His Asp Gly Thr 
    210                 215                 220                 


Ile Glu Phe Thr Ser Ile Asp Ala His Asn Gly Val Ala Pro Ser Arg 
225                 230                 235                 240 


Arg Gly Asp Leu Glu Ile Leu Gly Tyr Cys Met Ile Gln Trp Leu Thr 
                245                 250                 255     


Gly His Leu Pro Trp Glu Asp Asn Leu Lys Asp Pro Lys Tyr Val Arg 
            260                 265                 270         


Asp Ser Lys Ile Arg Tyr Arg Glu Asn Ile Ala Ser Leu Met Asp Lys 
        275                 280                 285             


Cys Phe Pro Glu Lys Asn Lys Pro Gly Glu Ile Ala Lys Tyr Met Glu 
    290                 295                 300                 


Thr Val Lys Leu Leu Asp Tyr Thr Glu Lys Pro Leu Tyr Glu Asn Leu 
305                 310                 315                 320 


Arg Asp Ile Leu Leu Gln Gly Leu Lys Ala Ile Gly Ser Lys Asp Asp 
                325                 330                 335     


Gly Lys Leu Asp Leu Ser Val Val Glu Asn Gly Gly Leu Lys Ala Lys 
            340                 345                 350         


Thr Ile Thr Lys Lys Arg Lys Lys Glu Ile Glu Glu Ser Lys Glu Pro 
        355                 360                 365             


Gly Val Glu Asp Thr Glu Trp Ser Asn Thr Gln Thr Glu Glu Ala Ile 
    370                 375                 380                 


Gln Thr Arg Ser Arg Thr Arg Lys Arg Val Gln Lys 
385                 390                 395     


<210>  2830
<211>  2812
<212>  PRT
<213>  Homo sapiens

<400>  2830

Met Val Pro Pro Val Trp Thr Leu Leu Leu Leu Val Gly Ala Ala Leu 
1               5                   10                  15      


Phe Arg Lys Glu Lys Pro Pro Asp Gln Lys Leu Val Val Arg Ser Ser 
            20                  25                  30          


Arg Asp Asn Tyr Val Leu Thr Gln Cys Asp Phe Glu Asp Asp Ala Lys 
        35                  40                  45              


Pro Leu Cys Asp Trp Ser Gln Val Ser Ala Asp Asp Glu Asp Trp Val 
    50                  55                  60                  


Arg Ala Ser Gly Pro Ser Pro Thr Gly Ser Thr Gly Ala Pro Gly Gly 
65                  70                  75                  80  


Tyr Pro Asn Gly Glu Gly Ser Tyr Leu His Met Glu Ser Asn Ser Phe 
                85                  90                  95      


His Arg Gly Gly Val Ala Arg Leu Leu Ser Pro Asp Leu Trp Glu Gln 
            100                 105                 110         


Gly Pro Leu Cys Val His Phe Ala His His Met Phe Gly Leu Ser Trp 
        115                 120                 125             


Gly Ala Gln Leu Arg Leu Leu Leu Leu Ser Gly Glu Glu Gly Arg Arg 
    130                 135                 140                 


Pro Asp Val Leu Trp Lys His Trp Asn Thr Gln Arg Pro Ser Trp Met 
145                 150                 155                 160 


Leu Thr Thr Val Thr Val Pro Ala Gly Phe Thr Leu Pro Thr Arg Leu 
                165                 170                 175     


Met Phe Glu Gly Thr Arg Gly Ser Thr Ala Tyr Leu Asp Ile Ala Leu 
            180                 185                 190         


Asp Ala Leu Ser Ile Arg Arg Gly Ser Cys Asn Arg Val Cys Met Met 
        195                 200                 205             


Gln Thr Cys Ser Phe Asp Ile Pro Asn Asp Leu Cys Asp Trp Thr Trp 
    210                 215                 220                 


Ile Pro Thr Ala Ser Gly Ala Lys Trp Thr Gln Lys Lys Gly Ser Ser 
225                 230                 235                 240 


Gly Lys Pro Gly Val Gly Pro Asp Gly Asp Phe Ser Ser Pro Gly Ser 
                245                 250                 255     


Gly Cys Tyr Met Leu Leu Asp Pro Lys Asn Ala Arg Pro Gly Gln Lys 
            260                 265                 270         


Ala Val Leu Leu Ser Pro Val Ser Leu Ser Ser Gly Cys Leu Ser Phe 
        275                 280                 285             


Ser Phe His Tyr Ile Leu Arg Gly Gln Ser Pro Gly Ala Ala Leu His 
    290                 295                 300                 


Ile Tyr Ala Ser Val Leu Gly Ser Ile Arg Lys His Thr Leu Phe Ser 
305                 310                 315                 320 


Gly Gln Pro Gly Pro Asn Trp Gln Ala Val Ser Val Asn Tyr Thr Ala 
                325                 330                 335     


Val Gly Arg Ile Gln Phe Ala Val Val Gly Val Phe Gly Lys Thr Pro 
            340                 345                 350         


Glu Pro Ala Val Ala Val Asp Ala Thr Ser Ile Ala Pro Cys Gly Glu 
        355                 360                 365             


Gly Phe Pro Gln Cys Asp Phe Glu Asp Asn Ala His Pro Phe Cys Asp 
    370                 375                 380                 


Trp Val Gln Thr Ser Gly Asp Gly Gly His Trp Ala Leu Gly His Lys 
385                 390                 395                 400 


Asn Gly Pro Val His Gly Met Gly Pro Ala Gly Gly Phe Pro Asn Ala 
                405                 410                 415     


Gly Gly His Tyr Ile Tyr Leu Glu Ala Asp Glu Phe Ser Gln Ala Gly 
            420                 425                 430         


Gln Ser Val Arg Leu Val Ser Arg Pro Phe Cys Ala Pro Gly Asp Ile 
        435                 440                 445             


Cys Val Glu Phe Ala Tyr His Met Tyr Gly Leu Gly Glu Gly Thr Met 
    450                 455                 460                 


Leu Glu Leu Leu Leu Gly Ser Pro Ala Gly Ser Pro Pro Ile Pro Leu 
465                 470                 475                 480 


Trp Lys Arg Val Gly Ser Gln Arg Pro Tyr Trp Gln Asn Thr Ser Val 
                485                 490                 495     


Thr Val Pro Ser Gly His Gln Gln Pro Met Gln Leu Ile Phe Lys Gly 
            500                 505                 510         


Ile Gln Gly Ser Asn Thr Ala Ser Val Val Ala Met Gly Phe Ile Leu 
        515                 520                 525             


Ile Asn Pro Gly Thr Cys Pro Val Lys Val Leu Pro Glu Leu Pro Pro 
    530                 535                 540                 


Val Ser Pro Val Ser Ser Thr Gly Pro Ser Glu Thr Thr Gly Leu Thr 
545                 550                 555                 560 


Glu Asn Pro Thr Ile Ser Thr Lys Lys Pro Thr Val Ser Ile Glu Lys 
                565                 570                 575     


Pro Ser Val Thr Thr Glu Lys Pro Thr Val Pro Lys Glu Lys Pro Thr 
            580                 585                 590         


Ile Pro Thr Glu Lys Pro Thr Ile Ser Thr Glu Lys Pro Thr Ile Pro 
        595                 600                 605             


Ser Glu Lys Pro Asn Met Pro Ser Glu Lys Pro Thr Ile Pro Ser Glu 
    610                 615                 620                 


Lys Pro Thr Ile Leu Thr Glu Lys Pro Thr Ile Pro Ser Glu Lys Pro 
625                 630                 635                 640 


Thr Ile Pro Ser Glu Lys Pro Thr Ile Ser Thr Glu Lys Pro Thr Val 
                645                 650                 655     


Pro Thr Glu Glu Pro Thr Thr Pro Thr Glu Glu Thr Thr Thr Ser Met 
            660                 665                 670         


Glu Glu Pro Val Ile Pro Thr Glu Lys Pro Ser Ile Pro Thr Glu Lys 
        675                 680                 685             


Pro Ser Ile Pro Thr Glu Lys Pro Thr Ile Ser Met Glu Glu Thr Ile 
    690                 695                 700                 


Ile Ser Thr Glu Lys Pro Thr Ile Ser Pro Glu Lys Pro Thr Ile Pro 
705                 710                 715                 720 


Thr Glu Lys Pro Thr Ile Pro Thr Glu Lys Ser Thr Ile Ser Pro Glu 
                725                 730                 735     


Lys Pro Thr Thr Pro Thr Glu Lys Pro Thr Ile Pro Thr Glu Lys Pro 
            740                 745                 750         


Thr Ile Ser Pro Glu Lys Pro Thr Thr Pro Thr Glu Lys Pro Thr Ile 
        755                 760                 765             


Ser Pro Glu Lys Leu Thr Ile Pro Thr Glu Lys Pro Thr Ile Pro Thr 
    770                 775                 780                 


Glu Lys Pro Thr Ile Pro Thr Glu Lys Pro Thr Ile Ser Thr Glu Glu 
785                 790                 795                 800 


Pro Thr Thr Pro Thr Glu Glu Thr Thr Ile Ser Thr Glu Lys Pro Ser 
                805                 810                 815     


Ile Pro Met Glu Lys Pro Thr Leu Pro Thr Glu Glu Thr Thr Thr Ser 
            820                 825                 830         


Val Glu Glu Thr Thr Ile Ser Thr Glu Lys Leu Thr Ile Pro Met Glu 
        835                 840                 845             


Lys Pro Thr Ile Ser Thr Glu Lys Pro Thr Ile Pro Thr Glu Lys Pro 
    850                 855                 860                 


Thr Ile Ser Pro Glu Lys Leu Thr Ile Pro Thr Glu Lys Leu Thr Ile 
865                 870                 875                 880 


Pro Thr Glu Lys Pro Thr Ile Pro Ile Glu Glu Thr Thr Ile Ser Thr 
                885                 890                 895     


Glu Lys Leu Thr Ile Pro Thr Glu Lys Pro Thr Ile Ser Pro Glu Lys 
            900                 905                 910         


Pro Thr Ile Ser Thr Glu Lys Pro Thr Ile Pro Thr Glu Lys Pro Thr 
        915                 920                 925             


Ile Pro Thr Glu Glu Thr Thr Ile Ser Thr Glu Lys Leu Thr Ile Pro 
    930                 935                 940                 


Thr Glu Lys Pro Thr Ile Ser Pro Glu Lys Leu Thr Ile Pro Thr Glu 
945                 950                 955                 960 


Lys Pro Thr Ile Ser Thr Glu Lys Pro Thr Ile Pro Thr Glu Lys Leu 
                965                 970                 975     


Thr Ile Pro Thr Glu Lys Pro Thr Ile Pro Thr Glu Lys Pro Thr Ile 
            980                 985                 990         


Pro Thr Glu Lys Leu Thr Ala Leu  Arg Pro Pro His Pro  Ser Pro Thr 
        995                 1000                 1005             


Ala Thr  Gly Leu Ala Ala Leu  Val Met Ser Pro His  Ala Pro Ser 
    1010                 1015                 1020             


Thr Pro  Met Thr Ser Val Ile  Leu Gly Thr Thr Thr  Thr Ser Arg 
    1025                 1030                 1035             


Ser Ser  Thr Glu Arg Cys Pro  Pro Asn Ala Arg Tyr  Glu Ser Cys 
    1040                 1045                 1050             


Ala Cys  Pro Ala Ser Cys Lys  Ser Pro Arg Pro Ser  Cys Gly Pro 
    1055                 1060                 1065             


Leu Cys  Arg Glu Gly Cys Val  Cys Asn Pro Gly Phe  Leu Phe Ser 
    1070                 1075                 1080             


Asp Asn  His Cys Ile Gln Ala  Ser Ser Cys Asn Cys  Phe Tyr Asn 
    1085                 1090                 1095             


Asn Asp  Tyr Tyr Glu Pro Gly  Ala Glu Trp Phe Ser  Pro Asn Cys 
    1100                 1105                 1110             


Thr Glu  His Cys Arg Cys Trp  Pro Gly Ser Arg Val  Glu Cys Gln 
    1115                 1120                 1125             


Ile Ser  Gln Cys Gly Thr His  Thr Val Cys Gln Leu  Lys Asn Gly 
    1130                 1135                 1140             


Gln Tyr  Gly Cys His Pro Tyr  Ala Gly Thr Ala Thr  Cys Leu Val 
    1145                 1150                 1155             


Tyr Gly  Asp Pro His Tyr Val  Thr Phe Asp Gly Arg  His Phe Gly 
    1160                 1165                 1170             


Phe Met  Gly Lys Cys Thr Tyr  Ile Leu Ala Gln Pro  Cys Gly Asn 
    1175                 1180                 1185             


Ser Thr  Asp Pro Phe Phe Arg  Val Thr Ala Lys Asn  Glu Glu Gln 
    1190                 1195                 1200             


Gly Gln  Glu Gly Val Ser Cys  Leu Ser Lys Val Tyr  Val Thr Leu 
    1205                 1210                 1215             


Pro Glu  Ser Thr Val Thr Leu  Leu Lys Gly Arg Arg  Thr Leu Val 
    1220                 1225                 1230             


Gly Gly  Gln Gln Val Thr Leu  Pro Ala Ile Pro Ser  Lys Gly Val 
    1235                 1240                 1245             


Phe Leu  Gly Ala Ser Gly Arg  Phe Val Glu Leu Gln  Thr Glu Phe 
    1250                 1255                 1260             


Gly Leu  Arg Val Arg Trp Asp  Gly Asp Gln Gln Leu  Tyr Val Thr 
    1265                 1270                 1275             


Val Ser  Ser Thr Tyr Ser Gly  Lys Leu Cys Gly Leu  Cys Gly Asn 
    1280                 1285                 1290             


Tyr Asp  Gly Asn Ser Asp Asn  Asp His Leu Lys Leu  Asp Gly Ser 
    1295                 1300                 1305             


Pro Ala  Gly Asp Lys Glu Glu  Leu Gly Asn Ser Trp  Gln Thr Asp 
    1310                 1315                 1320             


Gln Asp  Glu Asp Gln Glu Cys  Gln Lys Tyr Gln Val  Val Asn Ser 
    1325                 1330                 1335             


Pro Ser  Cys Asp Ser Ser Leu  Gln Ser Ser Met Ser  Gly Pro Gly 
    1340                 1345                 1350             


Phe Cys  Gly Arg Leu Val Asp  Thr His Gly Pro Phe  Glu Thr Cys 
    1355                 1360                 1365             


Leu Leu  His Val Lys Ala Ala  Ser Phe Phe Asp Ser  Cys Met Leu 
    1370                 1375                 1380             


Asp Met  Cys Gly Phe Gln Gly  Leu Gln His Leu Leu  Cys Thr His 
    1385                 1390                 1395             


Met Ser  Thr Met Thr Thr Thr  Cys Gln Asp Ala Gly  His Ala Val 
    1400                 1405                 1410             


Lys Pro  Trp Arg Glu Pro His  Phe Cys Pro Met Ala  Cys Pro Pro 
    1415                 1420                 1425             


Asn Ser  Lys Tyr Ser Leu Cys  Ala Lys Pro Cys Pro  Asp Thr Cys 
    1430                 1435                 1440             


His Ser  Gly Phe Ser Gly Met  Phe Cys Ser Asp Arg  Cys Val Glu 
    1445                 1450                 1455             


Ala Cys  Glu Cys Asn Pro Gly  Phe Val Leu Ser Gly  Leu Glu Cys 
    1460                 1465                 1470             


Ile Pro  Arg Ser Gln Cys Gly  Cys Leu His Pro Ala  Gly Ser Tyr 
    1475                 1480                 1485             


Phe Lys  Val Gly Glu Arg Trp  Tyr Lys Pro Gly Cys  Lys Glu Leu 
    1490                 1495                 1500             


Cys Val  Cys Glu Ser Asn Asn  Arg Ile Arg Cys Gln  Pro Trp Arg 
    1505                 1510                 1515             


Cys Arg  Ala Gln Glu Phe Cys  Gly Gln Gln Asp Gly  Ile Tyr Gly 
    1520                 1525                 1530             


Cys His  Ala Gln Gly Ala Ala  Thr Cys Thr Ala Ser  Gly Asp Pro 
    1535                 1540                 1545             


His Tyr  Leu Thr Phe Asp Gly  Ala Leu His His Phe  Met Gly Thr 
    1550                 1555                 1560             


Cys Thr  Tyr Val Leu Thr Arg  Pro Cys Trp Ser Arg  Ser Gln Asp 
    1565                 1570                 1575             


Ser Tyr  Phe Val Val Ser Ala  Thr Asn Glu Asn Arg  Gly Gly Ile 
    1580                 1585                 1590             


Leu Glu  Val Ser Tyr Ile Lys  Ala Val His Val Thr  Val Phe Asp 
    1595                 1600                 1605             


Leu Ser  Ile Ser Leu Leu Arg  Gly Cys Lys Val Met  Leu Asn Gly 
    1610                 1615                 1620             


His Arg  Val Ala Leu Pro Val  Trp Leu Ala Gln Gly  Arg Val Thr 
    1625                 1630                 1635             


Ile Arg  Leu Ser Ser Asn Leu  Val Leu Leu Tyr Thr  Asn Phe Gly 
    1640                 1645                 1650             


Leu Gln  Val Arg Tyr Asp Gly  Ser His Leu Val Glu  Val Thr Val 
    1655                 1660                 1665             


Pro Ser  Ser Tyr Gly Gly Gln  Leu Cys Gly Leu Cys  Gly Asn Tyr 
    1670                 1675                 1680             


Asn Asn  Asn Ser Leu Asp Asp  Asn Leu Arg Pro Asp  Arg Lys Leu 
    1685                 1690                 1695             


Ala Gly  Asp Ser Met Gln Leu  Gly Ala Ala Trp Lys  Leu Pro Glu 
    1700                 1705                 1710             


Ser Ser  Glu Pro Gly Cys Phe  Leu Val Gly Gly Lys  Pro Ser Ser 
    1715                 1720                 1725             


Cys Gln  Glu Asn Ser Met Ala  Asp Ala Trp Asn Lys  Asn Cys Ala 
    1730                 1735                 1740             


Ile Leu  Ile Asn Pro Gln Gly  Pro Phe Ser Gln Cys  His Gln Val 
    1745                 1750                 1755             


Val Pro  Pro Gln Ser Ser Phe  Ala Ser Cys Val His  Gly Gln Cys 
    1760                 1765                 1770             


Gly Thr  Lys Gly Asp Thr Thr  Ala Leu Cys Arg Ser  Leu Gln Ala 
    1775                 1780                 1785             


Tyr Ala  Ser Leu Cys Ala Gln  Ala Gly Gln Ala Pro  Ala Trp Arg 
    1790                 1795                 1800             


Asn Arg  Thr Phe Cys Pro Met  Arg Cys Pro Pro Gly  Ser Ser Tyr 
    1805                 1810                 1815             


Ser Pro  Cys Ser Ser Pro Cys  Pro Asp Thr Cys Ser  Ser Ile Asn 
    1820                 1825                 1830             


Asn Pro  Arg Asp Cys Pro Lys  Ala Leu Pro Cys Ala  Glu Ser Cys 
    1835                 1840                 1845             


Glu Cys  Gln Lys Gly His Ile  Leu Ser Gly Thr Ser  Cys Val Pro 
    1850                 1855                 1860             


Leu Gly  Gln Cys Gly Cys Thr  Asp Pro Ala Gly Ser  Tyr His Pro 
    1865                 1870                 1875             


Val Gly  Glu Arg Trp Tyr Thr  Glu Asn Thr Cys Thr  Arg Leu Cys 
    1880                 1885                 1890             


Thr Cys  Ser Val His Asn Asn  Ile Thr Cys Phe Gln  Ser Thr Cys 
    1895                 1900                 1905             


Lys Pro  Asn Gln Ile Cys Trp  Ala Leu Asp Gly Leu  Leu His Cys 
    1910                 1915                 1920             


Arg Ala  Ser Gly Val Gly Val  Cys Gln Leu Pro Gly  Glu Ser His 
    1925                 1930                 1935             


Tyr Val  Ser Phe Asp Gly Ser  Asn His Ser Ile Pro  Asp Ala Cys 
    1940                 1945                 1950             


Thr Leu  Val Leu Val Lys Val  Cys His Pro Ala Met  Ala Leu Pro 
    1955                 1960                 1965             


Phe Phe  Lys Ile Ser Ala Lys  His Glu Lys Glu Glu  Gly Gly Thr 
    1970                 1975                 1980             


Glu Ala  Phe Arg Leu His Glu  Val Tyr Ile Asp Ile  Tyr Asp Ala 
    1985                 1990                 1995             


Gln Val  Thr Leu Gln Lys Gly  His Arg Val Leu Ile  Asn Ser Lys 
    2000                 2005                 2010             


Gln Val  Thr Leu Pro Ala Ile  Ser Gln Ile Pro Gly  Val Ser Val 
    2015                 2020                 2025             


Lys Ser  Ser Ser Ile Tyr Ser  Ile Val Asn Ile Lys  Ile Gly Val 
    2030                 2035                 2040             


Gln Val  Lys Phe Asp Gly Asn  His Leu Leu Glu Ile  Glu Ile Pro 
    2045                 2050                 2055             


Thr Thr  Tyr Tyr Gly Lys Val  Cys Gly Met Cys Gly  Asn Phe Asn 
    2060                 2065                 2070             


Asp Glu  Glu Glu Asp Glu Leu  Met Met Pro Ser Asp  Glu Val Ala 
    2075                 2080                 2085             


Asn Ser  Asp Ser Glu Phe Val  Asn Ser Trp Lys Asp  Lys Asp Ile 
    2090                 2095                 2100             


Asp Pro  Ser Cys Gln Ser Leu  Leu Val Asp Glu Gln  Gln Ile Pro 
    2105                 2110                 2115             


Ala Glu  Gln Gln Glu Asn Pro  Ser Gly Asn Cys Arg  Ala Ala Asp 
    2120                 2125                 2130             


Leu Arg  Arg Ala Arg Glu Lys  Cys Glu Ala Ala Leu  Arg Ala Pro 
    2135                 2140                 2145             


Val Trp  Ala Gln Cys Ala Ser  Arg Ile Asp Leu Thr  Pro Phe Leu 
    2150                 2155                 2160             


Val Asp  Cys Ala Asn Thr Leu  Cys Glu Phe Gly Gly  Leu Tyr Gln 
    2165                 2170                 2175             


Ala Leu  Cys Gln Ala Leu Gln  Ala Phe Gly Ala Thr  Cys Gln Ser 
    2180                 2185                 2190             


Gln Gly  Leu Lys Pro Pro Leu  Trp Arg Asn Ser Ser  Phe Cys Pro 
    2195                 2200                 2205             


Leu Glu  Cys Pro Ala Tyr Ser  Ser Tyr Thr Asn Cys  Leu Pro Ser 
    2210                 2215                 2220             


Cys Ser  Pro Ser Cys Trp Asp  Leu Asp Gly Arg Cys  Glu Gly Ala 
    2225                 2230                 2235             


Lys Val  Pro Ser Ala Cys Ala  Glu Gly Cys Ile Cys  Gln Pro Gly 
    2240                 2245                 2250             


Tyr Val  Leu Ser Glu Asp Lys  Cys Val Pro Arg Ser  Gln Cys Gly 
    2255                 2260                 2265             


Cys Lys  Asp Ala His Gly Gly  Ser Ile Pro Leu Gly  Lys Ser Trp 
    2270                 2275                 2280             


Val Ser  Ser Gly Cys Thr Glu  Lys Cys Val Cys Thr  Gly Gly Ala 
    2285                 2290                 2295             


Ile Gln  Cys Gly Asp Phe Arg  Cys Pro Ser Gly Ser  His Cys Gln 
    2300                 2305                 2310             


Leu Thr  Ser Asp Asn Ser Asn  Ser Asn Cys Val Ser  Asp Lys Ser 
    2315                 2320                 2325             


Glu Gln  Cys Ser Val Tyr Gly  Asp Pro Arg Tyr Leu  Thr Phe Asp 
    2330                 2335                 2340             


Gly Phe  Ser Tyr Arg Leu Gln  Gly Arg Met Thr Tyr  Val Leu Ile 
    2345                 2350                 2355             


Lys Thr  Val Asp Val Leu Pro  Glu Gly Val Glu Pro  Leu Leu Val 
    2360                 2365                 2370             


Glu Gly  Arg Asn Lys Met Asp  Pro Pro Arg Ser Ser  Ile Phe Leu 
    2375                 2380                 2385             


Gln Glu  Val Ile Thr Thr Val  Tyr Gly Tyr Lys Val  Gln Leu Gln 
    2390                 2395                 2400             


Ala Gly  Leu Glu Leu Val Val  Asn Asn Gln Lys Met  Ala Val Pro 
    2405                 2410                 2415             


Tyr Arg  Pro Asn Glu His Leu  Arg Val Thr Leu Trp  Gly Gln Arg 
    2420                 2425                 2430             


Leu Tyr  Leu Val Thr Asp Phe  Glu Leu Val Val Ser  Phe Gly Gly 
    2435                 2440                 2445             


Arg Lys  Asn Ala Val Ile Ser  Leu Pro Ser Met Tyr  Glu Gly Leu 
    2450                 2455                 2460             


Val Ser  Gly Leu Cys Gly Asn  Tyr Asp Lys Asn Arg  Lys Asn Asp 
    2465                 2470                 2475             


Met Met  Leu Pro Ser Gly Ala  Leu Thr Gln Asn Leu  Asn Thr Phe 
    2480                 2485                 2490             


Gly Asn  Ser Trp Glu Val Lys  Thr Glu Asp Ala Leu  Leu Arg Phe 
    2495                 2500                 2505             


Pro Arg  Ala Ile Pro Ala Glu  Glu Glu Gly Gln Gly  Ala Glu Leu 
    2510                 2515                 2520             


Gly Leu  Arg Thr Gly Leu Gln  Val Ser Glu Cys Ser  Pro Glu Gln 
    2525                 2530                 2535             


Leu Ala  Ser Asn Ser Thr Gln  Ala Cys Arg Val Leu  Ala Asp Pro 
    2540                 2545                 2550             


Gln Gly  Pro Phe Ala Ala Cys  His Gln Thr Val Ala  Pro Glu Pro 
    2555                 2560                 2565             


Phe Gln  Glu His Cys Val Leu  Asp Leu Cys Ser Ala  Gln Asp Pro 
    2570                 2575                 2580             


Arg Glu  Gln Glu Glu Leu Arg  Cys Gln Val Leu Ser  Gly His Gly 
    2585                 2590                 2595             


Val Ser  Ser Arg Tyr His Ile  Ser Glu Leu Tyr Asp  Thr Leu Pro 
    2600                 2605                 2610             


Ser Ile  Leu Cys Gln Pro Gly  Arg Pro Arg Gly Leu  Arg Gly Pro 
    2615                 2620                 2625             


Leu Arg  Gly Arg Leu Arg Gln  His Pro Arg Leu Cys  Leu Gln Trp 
    2630                 2635                 2640             


His Pro  Glu Pro Pro Leu Ala  Asp Cys Gly Cys Thr  Ser Asn Gly 
    2645                 2650                 2655             


Ile Tyr  Tyr Gln Leu Gly Ser  Ser Phe Leu Thr Glu  Asp Cys Ser 
    2660                 2665                 2670             


Gln Arg  Cys Thr Cys Ala Ser  Ser Arg Ile Leu Leu  Cys Glu Pro 
    2675                 2680                 2685             


Phe Ser  Cys Arg Ala Gly Glu  Val Cys Thr Leu Gly  Asn His Thr 
    2690                 2695                 2700             


Gln Gly  Cys Phe Pro Glu Ser  Pro Cys Leu Gln Asn  Pro Cys Gln 
    2705                 2710                 2715             


Asn Asp  Gly Gln Cys Arg Glu  Gln Gly Ala Thr Phe  Thr Cys Glu 
    2720                 2725                 2730             


Cys Glu  Val Gly Tyr Gly Gly  Gly Leu Cys Met Glu  Pro Arg Asp 
    2735                 2740                 2745             


Ala Pro  Pro Pro Arg Lys Pro  Ala Ser Asn Leu Val  Gly Val Leu 
    2750                 2755                 2760             


Leu Gly  Leu Leu Val Pro Val  Val Val Val Leu Leu  Ala Val Thr 
    2765                 2770                 2775             


Arg Glu  Cys Ile Tyr Arg Thr  Arg Arg Lys Arg Glu  Lys Thr Gln 
    2780                 2785                 2790             


Glu Gly  Asp Arg Leu Ala Arg  Leu Val Asp Thr Asp  Thr Val Leu 
    2795                 2800                 2805             


Asp Cys  Ala Cys 
    2810         


<210>  2831
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  2831

Met Lys Lys Ser Ile Gly Ile Leu Ser Pro Gly Val Ala Leu Gly Met 
1               5                   10                  15      


Ala Gly Ser Ala Met Ser Ser Lys Phe Phe Leu Val Ala Leu Ala Ile 
            20                  25                  30          


Phe Phe Ser Phe Ala Gln Val Val Ile Glu Ala Asn Ser Trp Trp Ser 
        35                  40                  45              


Leu Gly Met Asn Asn Pro Val Gln Met Ser Glu Val Tyr Ile Ile Gly 
    50                  55                  60                  


Ala Gln Pro Leu Cys Ser Gln Leu Ala Gly Leu Ser Gln Gly Gln Lys 
65                  70                  75                  80  


Lys Leu Cys His Leu Tyr Gln Asp His Met Gln Tyr Ile Gly Glu Gly 
                85                  90                  95      


Ala Lys Thr Gly Ile Lys Glu Cys Gln Tyr Gln Phe Arg His Arg Arg 
            100                 105                 110         


Trp Asn Cys Ser Thr Val Asp Asn Thr Ser Val Phe Gly Arg Val Met 
        115                 120                 125             


Gln Ile Gly Ser Arg Glu Thr Ala Phe Thr Tyr Ala Val Ser Ala Ala 
    130                 135                 140                 


Gly Val Val Asn Ala Met Ser Arg Ala Cys Arg Glu Gly Glu Leu Ser 
145                 150                 155                 160 


Thr Cys Gly Cys Ser Arg Ala Ala Arg Pro Lys Asp Leu Pro Arg Asp 
                165                 170                 175     


Trp Leu Trp Gly Gly Cys Gly Asp Asn Ile Asp Tyr Gly Tyr Arg Phe 
            180                 185                 190         


Ala Lys Glu Phe Val Asp Ala Arg Glu Arg Glu Arg Ile His Ala Lys 
        195                 200                 205             


Gly Ser Tyr Glu Ser Ala Arg Ile Leu Met Asn Leu His Asn Asn Glu 
    210                 215                 220                 


Ala Gly Arg Arg Thr Val Tyr Asn Leu Ala Asp Val Ala Cys Lys Cys 
225                 230                 235                 240 


His Gly Val Ser Gly Ser Cys Ser Leu Lys Thr Cys Trp Leu Gln Leu 
                245                 250                 255     


Ala Asp Phe Arg Lys Val Gly Asp Ala Leu Lys Glu Lys Tyr Asp Ser 
            260                 265                 270         


Ala Ala Ala Met Arg Leu Asn Ser Arg Gly Lys Leu Val Gln Val Asn 
        275                 280                 285             


Ser Arg Phe Asn Ser Pro Thr Thr Gln Asp Leu Val Tyr Ile Asp Pro 
    290                 295                 300                 


Ser Pro Asp Tyr Cys Val Arg Asn Glu Ser Thr Gly Ser Leu Gly Thr 
305                 310                 315                 320 


Gln Gly Arg Leu Cys Asn Lys Thr Ser Glu Gly Met Asp Gly Cys Glu 
                325                 330                 335     


Leu Met Cys Cys Gly Arg Gly Tyr Asp Gln Phe Lys Thr Val Gln Thr 
            340                 345                 350         


Glu Arg Cys His Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys Lys 
        355                 360                 365             


Lys Cys Thr Glu Ile Val Asp Gln Phe Val Cys Lys 
    370                 375                 380 


<210>  2832
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  2832

Met Arg Pro Pro Pro Ala Leu Ala Leu Ala Gly Leu Cys Leu Leu Ala 
1               5                   10                  15      


Leu Pro Ala Ala Ala Ala Ser Tyr Phe Gly Leu Thr Gly Arg Glu Val 
            20                  25                  30          


Leu Thr Pro Phe Pro Gly Leu Gly Thr Ala Ala Ala Pro Ala Gln Gly 
        35                  40                  45              


Gly Ala His Leu Lys Gln Cys Asp Leu Leu Lys Leu Ser Arg Arg Gln 
    50                  55                  60                  


Lys Gln Leu Cys Arg Arg Glu Pro Gly Leu Ala Glu Thr Leu Arg Asp 
65                  70                  75                  80  


Ala Ala His Leu Gly Leu Leu Glu Cys Gln Phe Gln Phe Arg His Glu 
                85                  90                  95      


Arg Trp Asn Cys Ser Leu Glu Gly Arg Met Gly Leu Leu Lys Arg Gly 
            100                 105                 110         


Phe Lys Glu Thr Ala Phe Leu Tyr Ala Val Ser Ser Ala Ala Leu Thr 
        115                 120                 125             


His Thr Leu Ala Arg Ala Cys Ser Ala Gly Arg Met Glu Arg Cys Thr 
    130                 135                 140                 


Cys Asp Asp Ser Pro Gly Leu Glu Ser Arg Gln Ala Trp Gln Trp Gly 
145                 150                 155                 160 


Val Cys Gly Asp Asn Leu Lys Tyr Ser Thr Lys Phe Leu Ser Asn Phe 
                165                 170                 175     


Leu Gly Ser Lys Arg Gly Asn Lys Asp Leu Arg Ala Arg Ala Asp Ala 
            180                 185                 190         


His Asn Thr His Val Gly Ile Lys Ala Val Lys Ser Gly Leu Arg Thr 
        195                 200                 205             


Thr Cys Lys Cys His Gly Val Ser Gly Ser Cys Ala Val Arg Thr Cys 
    210                 215                 220                 


Trp Lys Gln Leu Ser Pro Phe Arg Glu Thr Gly Gln Val Leu Lys Leu 
225                 230                 235                 240 


Arg Tyr Asp Ser Ala Val Lys Val Ser Ser Ala Thr Asn Glu Ala Leu 
                245                 250                 255     


Gly Arg Leu Glu Leu Trp Ala Pro Ala Arg Gln Gly Ser Leu Thr Lys 
            260                 265                 270         


Gly Leu Ala Pro Arg Ser Gly Asp Leu Val Tyr Met Glu Asp Ser Pro 
        275                 280                 285             


Ser Phe Cys Arg Pro Ser Lys Tyr Ser Pro Gly Thr Ala Gly Arg Val 
    290                 295                 300                 


Cys Ser Arg Glu Ala Ser Cys Ser Ser Leu Cys Cys Gly Arg Gly Tyr 
305                 310                 315                 320 


Asp Thr Gln Ser Arg Leu Val Ala Phe Ser Cys His Cys Gln Val Gln 
                325                 330                 335     


Trp Cys Cys Tyr Val Glu Cys Gln Gln Cys Val Gln Glu Glu Leu Val 
            340                 345                 350         


Tyr Thr Cys Lys His 
        355         


<210>  2833
<211>  686
<212>  PRT
<213>  Homo sapiens

<400>  2833

Met Glu Val Val Thr Phe Gly Asp Val Ala Val His Phe Ser Arg Glu 
1               5                   10                  15      


Glu Trp Gln Cys Leu Asp Pro Gly Gln Arg Ala Leu Tyr Arg Glu Val 
            20                  25                  30          


Met Leu Glu Asn His Ser Ser Val Ala Gly Leu Ala Gly Phe Leu Val 
        35                  40                  45              


Phe Lys Pro Glu Leu Ile Ser Arg Leu Glu Gln Gly Glu Glu Pro Trp 
    50                  55                  60                  


Val Leu Asp Leu Gln Gly Ala Glu Gly Thr Glu Ala Pro Arg Thr Ser 
65                  70                  75                  80  


Lys Thr Asp Ser Thr Ile Arg Thr Glu Asn Glu Gln Ala Cys Glu Asp 
                85                  90                  95      


Met Asp Ile Leu Lys Ser Glu Ser Tyr Gly Thr Val Val Arg Ile Ser 
            100                 105                 110         


Pro Gln Asp Phe Pro Gln Asn Pro Gly Phe Gly Asp Val Ser Asp Ser 
        115                 120                 125             


Glu Val Trp Leu Asp Ser His Leu Gly Ser Pro Gly Leu Lys Val Thr 
    130                 135                 140                 


Gly Phe Thr Phe Gln Asn Asn Cys Leu Asn Glu Glu Thr Val Val Pro 
145                 150                 155                 160 


Lys Thr Phe Thr Lys Asp Ala Pro Gln Gly Cys Lys Glu Leu Gly Ser 
                165                 170                 175     


Ser Gly Leu Asp Cys Gln Pro Leu Glu Ser Gln Gly Glu Ser Ala Glu 
            180                 185                 190         


Gly Met Ser Gln Arg Cys Glu Glu Cys Gly Lys Gly Ile Arg Ala Thr 
        195                 200                 205             


Ser Asp Ile Ala Leu His Trp Glu Ile Asn Thr Gln Lys Ile Ser Arg 
    210                 215                 220                 


Cys Gln Glu Cys Gln Lys Lys Leu Ser Asp Cys Leu Gln Gly Lys His 
225                 230                 235                 240 


Thr Asn Asn Cys His Gly Glu Lys Pro Tyr Glu Cys Ala Glu Cys Gly 
                245                 250                 255     


Lys Val Phe Arg Leu Cys Ser Gln Leu Asn Gln His Gln Arg Ile His 
            260                 265                 270         


Thr Gly Glu Lys Pro Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Arg 
        275                 280                 285             


Leu Ser Ser Lys Leu Ile Gln His Gln Arg Ile His Thr Gly Glu Lys 
    290                 295                 300                 


Pro Tyr Arg Cys Glu Glu Cys Gly Lys Ala Phe Gly Gln Ser Ser Ser 
305                 310                 315                 320 


Leu Ile His His Gln Arg Ile His Thr Gly Glu Arg Pro Tyr Gly Cys 
                325                 330                 335     


Arg Glu Cys Gly Lys Ala Phe Ser Gln Gln Ser Gln Leu Val Arg His 
            340                 345                 350         


Gln Arg Thr His Thr Gly Glu Arg Pro Tyr Pro Cys Lys Glu Cys Gly 
        355                 360                 365             


Lys Ala Phe Ser Gln Ser Ser Thr Leu Ala Gln His Gln Arg Met His 
    370                 375                 380                 


Thr Gly Glu Lys Ala Gln Ile Leu Lys Ala Ser Asp Ser Pro Ser Leu 
385                 390                 395                 400 


Val Ala His Gln Arg Ile His Ala Val Glu Lys Pro Phe Lys Cys Asp 
                405                 410                 415     


Glu Cys Gly Lys Ala Phe Arg Trp Ile Ser Arg Leu Ser Gln His Gln 
            420                 425                 430         


Leu Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Lys Cys Thr Lys 
        435                 440                 445             


Ala Phe Gly Cys Ser Ser Arg Leu Ile Arg His Gln Arg Thr His Thr 
    450                 455                 460                 


Gly Glu Lys Pro Phe Lys Cys Asp Glu Cys Gly Lys Gly Phe Val Gln 
465                 470                 475                 480 


Gly Ser His Leu Ile Gln His Gln Arg Ile His Thr Gly Glu Lys Pro 
                485                 490                 495     


Tyr Val Cys Asn Asp Cys Gly Lys Ala Phe Ser Gln Ser Ser Ser Leu 
            500                 505                 510         


Ile Tyr His Gln Arg Ile His Lys Gly Glu Lys Pro Tyr Glu Cys Leu 
        515                 520                 525             


Gln Cys Gly Lys Ala Phe Ser Met Ser Thr Gln Leu Thr Ile His Gln 
    530                 535                 540                 


Arg Val His Thr Gly Glu Arg Pro Tyr Lys Cys Asn Glu Cys Gly Lys 
545                 550                 555                 560 


Ala Phe Ser Gln Asn Ser Thr Leu Phe Gln His Gln Ile Ile His Ala 
                565                 570                 575     


Gly Val Lys Pro Tyr Glu Cys Ser Glu Cys Gly Lys Ala Phe Ser Arg 
            580                 585                 590         


Ser Ser Tyr Leu Ile Glu His Gln Arg Ile His Thr Arg Ala Gln Trp 
        595                 600                 605             


Phe Tyr Glu Tyr Gly Asn Ala Leu Glu Gly Ser Thr Phe Val Ser Arg 
    610                 615                 620                 


Lys Lys Val Asn Thr Ile Lys Lys Leu His Gln Cys Glu Asp Cys Glu 
625                 630                 635                 640 


Lys Ile Phe Arg Trp Arg Ser His Leu Ile Ile His Gln Arg Ile His 
                645                 650                 655     


Thr Gly Glu Lys Pro Tyr Lys Cys Asn Asp Cys Gly Lys Ala Phe Asn 
            660                 665                 670         


Arg Ser Ser Arg Leu Thr Gln His Gln Lys Ile His Met Gly 
        675                 680                 685     


<210>  2834
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  2834

Met Glu Pro Ser Pro Ala Ala Gly Gly Leu Glu Thr Thr Arg Leu Val 
1               5                   10                  15      


Ser Pro Arg Asp Arg Gly Gly Ala Gly Gly Ser Leu Arg Leu Lys Ser 
            20                  25                  30          


Leu Phe Thr Glu Pro Ser Glu Pro Leu Pro Glu Glu Ser Lys Pro Val 
        35                  40                  45              


Glu Met Pro Phe His His Cys His Arg Asp Pro Leu Pro Pro Pro Gly 
    50                  55                  60                  


Leu Thr Pro Glu Arg Leu His Ala Arg Arg Gln Leu Tyr Ala Ala Cys 
65                  70                  75                  80  


Ala Val Cys Phe Val Phe Met Ala Gly Glu Val Val Gly Gly Tyr Leu 
                85                  90                  95      


Ala His Ser Leu Ala Ile Met Thr Asp Ala Ala His Leu Leu Ala Asp 
            100                 105                 110         


Val Gly Ser Met Met Gly Ser Leu Phe Ser Leu Trp Leu Ser Thr Arg 
        115                 120                 125             


Pro Ala Thr Arg Thr Met Thr Phe Gly Trp His Arg Ser Glu Thr Leu 
    130                 135                 140                 


Gly Ala Leu Ala Ser Val Val Ser Leu Trp Met Val Thr Gly Ile Leu 
145                 150                 155                 160 


Leu Tyr Leu Ala Phe Val Arg Leu Leu His Ser Asp Tyr His Ile Glu 
                165                 170                 175     


Gly Gly Ala Met Leu Leu Thr Ala Ser Ile Ala Val Cys Ala Asn Leu 
            180                 185                 190         


Leu Met Ala Phe Val Leu His Gln Ala Gly Pro Pro His Ser His Gly 
        195                 200                 205             


Ser Arg Gly Ala Glu Tyr Ala Pro Leu Glu Glu Gly Pro Glu Glu Pro 
    210                 215                 220                 


Leu Pro Leu Gly Asn Thr Ser Val Arg Ala Ala Phe Val His Val Leu 
225                 230                 235                 240 


Gly Asp Leu Leu Gln Ser Phe Gly Val Leu Ala Ala Ser Ile Leu Ile 
                245                 250                 255     


Tyr Phe Lys Pro Gln Tyr Lys Ala Ala Asp Pro Ile Ser Thr Phe Leu 
            260                 265                 270         


Phe Ser Ile Cys Ala Leu Gly Ser Thr Ala Pro Thr Leu Arg Asp Val 
        275                 280                 285             


Leu Arg Ile Leu Met Glu Gly Thr Pro Arg Asn Val Gly Phe Glu Pro 
    290                 295                 300                 


Val Arg Asp Thr Leu Leu Ser Val Pro Gly Val Arg Ala Thr His Glu 
305                 310                 315                 320 


Leu His Leu Trp Ala Leu Thr Leu Thr Tyr His Val Ala Ser Ala His 
                325                 330                 335     


Leu Ala Ile Asp Ser Thr Ala Asp Pro Glu Ala Val Leu Ala Glu Ala 
            340                 345                 350         


Ser Ser Arg Leu Tyr Ser Arg Phe Gly Phe Ser Ser Cys Thr Leu Gln 
        355                 360                 365             


Val Glu Gln Tyr Gln Pro Glu Met Ala Gln Cys Leu Arg Cys Gln Glu 
    370                 375                 380                 


Pro Pro Gln Ala 
385             


<210>  2835
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  2835

Met Val Arg Ser Val Ala Trp Ala Gly Phe Met Val Leu Leu Met Ile 
1               5                   10                  15      


Pro Trp Gly Ser Ala Ala Lys Leu Val Cys Tyr Phe Thr Asn Trp Ala 
            20                  25                  30          


Gln Tyr Arg Gln Gly Glu Ala Arg Phe Leu Pro Lys Asp Leu Asp Pro 
        35                  40                  45              


Ser Leu Cys Thr His Leu Ile Tyr Ala Phe Ala Gly Met Thr Asn His 
    50                  55                  60                  


Gln Leu Ser Thr Thr Glu Trp Asn Asp Glu Thr Leu Tyr Gln Glu Phe 
65                  70                  75                  80  


Asn Gly Leu Lys Lys Met Asn Pro Lys Leu Lys Thr Leu Leu Ala Ile 
                85                  90                  95      


Gly Gly Trp Asn Phe Gly Thr Gln Lys Phe Thr Asp Met Val Ala Thr 
            100                 105                 110         


Ala Asn Asn Arg Gln Thr Phe Val Asn Ser Ala Ile Arg Phe Leu Arg 
        115                 120                 125             


Lys Tyr Ser Phe Asp Gly Leu Asp Leu Asp Trp Glu Tyr Pro Gly Ser 
    130                 135                 140                 


Gln Gly Ser Pro Ala Val Asp Lys Glu Arg Phe Thr Thr Leu Val Gln 
145                 150                 155                 160 


Asp Leu Ala Asn Ala Phe Gln Gln Glu Ala Gln Thr Ser Gly Lys Glu 
                165                 170                 175     


Arg Leu Leu Leu Ser Ala Ala Val Pro Ala Gly Gln Thr Tyr Val Asp 
            180                 185                 190         


Ala Gly Tyr Glu Val Asp Lys Ile Ala Gln Asn Leu Asp Phe Val Asn 
        195                 200                 205             


Leu Met Ala Tyr Asp Phe His Gly Ser Trp Glu Lys Val Thr Gly His 
    210                 215                 220                 


Asn Ser Pro Leu Tyr Lys Arg Gln Glu Glu Ser Gly Ala Ala Ala Ser 
225                 230                 235                 240 


Leu Asn Val Asp Ala Ala Val Gln Gln Trp Leu Gln Lys Gly Thr Pro 
                245                 250                 255     


Ala Ser Lys Leu Ile Leu Gly Met Pro Thr Tyr Gly Arg Ser Phe Thr 
            260                 265                 270         


Leu Ala Ser Ser Ser Asp Thr Arg Val Gly Ala Pro Ala Thr Gly Ser 
        275                 280                 285             


Gly Thr Pro Gly Pro Phe Thr Lys Glu Gly Gly Met Leu Ala Tyr Tyr 
    290                 295                 300                 


Glu Val Cys Ser Trp Lys Gly Ala Thr Lys Gln Arg Ile Gln Asp Gln 
305                 310                 315                 320 


Lys Val Pro Tyr Ile Phe Arg Asp Asn Gln Trp Val Gly Phe Asp Asp 
                325                 330                 335     


Val Glu Ser Phe Lys Thr Lys Val Ser Tyr Leu Lys Gln Lys Gly Leu 
            340                 345                 350         


Gly Gly Ala Met Val Trp Ala Leu Asp Leu Asp Asp Phe Ala Gly Phe 
        355                 360                 365             


Ser Cys Asn Gln Gly Arg Tyr Pro Leu Ile Gln Thr Leu Arg Gln Glu 
    370                 375                 380                 


Leu Ser Leu Pro Tyr Leu Pro Ser Gly Thr Pro Glu Leu Glu Val Pro 
385                 390                 395                 400 


Lys Pro Gly Gln Pro Ser Glu Pro Glu His Gly Pro Ser Pro Gly Gln 
                405                 410                 415     


Asp Thr Phe Cys Gln Gly Lys Ala Asp Gly Leu Tyr Pro Asn Pro Arg 
            420                 425                 430         


Glu Arg Ser Ser Phe Tyr Ser Cys Ala Ala Gly Arg Leu Phe Gln Gln 
        435                 440                 445             


Ser Cys Pro Thr Gly Leu Val Phe Ser Asn Ser Cys Lys Cys Cys Thr 
    450                 455                 460                 


Trp Asn 
465     


<210>  2836
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  2836

Met Glu Gly Ile Ser Ile Tyr Thr Ser Asp Asn Tyr Thr Glu Glu Met 
1               5                   10                  15      


Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys Phe Arg Glu Glu 
            20                  25                  30          


Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile Tyr Ser Ile Ile 
        35                  40                  45              


Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val Met Gly 
    50                  55                  60                  


Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg Leu His Leu 
65                  70                  75                  80  


Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro Phe Trp Ala Val 
                85                  90                  95      


Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu Cys Lys Ala Val 
            100                 105                 110         


His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val Leu Ile Leu Ala 
        115                 120                 125             


Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr Asn Ser 
    130                 135                 140                 


Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val Tyr Val Gly Val 
145                 150                 155                 160 


Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe Ile Phe Ala Asn 
                165                 170                 175     


Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg Phe Tyr Pro Asn 
            180                 185                 190         


Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile Met Val Gly Leu 
        195                 200                 205             


Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys Ile Ile Ile Ser 
    210                 215                 220                 


Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys Ala Leu Lys Thr 
225                 230                 235                 240 


Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp Leu Pro Tyr Tyr 
                245                 250                 255     


Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu Ile Ile Lys Gln 
            260                 265                 270         


Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile Ser Ile Thr Glu 
        275                 280                 285             


Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile Leu Tyr Ala Phe 
    290                 295                 300                 


Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala Leu Thr Ser Val 
305                 310                 315                 320 


Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly Lys Arg Gly Gly 
                325                 330                 335     


His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser Phe His Ser Ser 
            340                 345                 350         


<210>  2837
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  2837

Met Ala Arg Pro Asp Pro Ser Ala Pro Pro Ser Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Gln Leu Val Gly Arg Ala Ala Ala Ala Ser Lys Ala Pro Val 
            20                  25                  30          


Cys Gln Glu Ile Thr Val Pro Met Cys Arg Gly Ile Gly Tyr Asn Leu 
        35                  40                  45              


Thr His Met Pro Asn Gln Phe Asn His Asp Thr Gln Asp Glu Ala Gly 
    50                  55                  60                  


Leu Glu Val His Gln Phe Trp Pro Leu Val Glu Ile Gln Cys Ser Pro 
65                  70                  75                  80  


Asp Leu Arg Phe Phe Leu Cys Ser Met Tyr Thr Pro Ile Cys Leu Pro 
                85                  90                  95      


Asp Tyr His Lys Pro Leu Pro Pro Cys Arg Ser Val Cys Glu Arg Ala 
            100                 105                 110         


Lys Ala Gly Cys Ser Pro Leu Met Arg Gln Tyr Gly Phe Ala Trp Pro 
        115                 120                 125             


Glu Arg Met Ser Cys Asp Arg Leu Pro Val Leu Gly Arg Asp Ala Glu 
    130                 135                 140                 


Val Leu Cys Met Asp Tyr Asn Arg Ser Glu Ala Thr Thr Ala Pro Pro 
145                 150                 155                 160 


Arg Pro Phe Pro Ala Lys Pro Thr Leu Pro Gly Pro Pro Gly Ala Pro 
                165                 170                 175     


Ala Ser Gly Gly Glu Cys Pro Ala Gly Gly Pro Phe Val Cys Lys Cys 
            180                 185                 190         


Arg Glu Pro Phe Val Pro Ile Leu Lys Glu Ser His Pro Leu Tyr Asn 
        195                 200                 205             


Lys Val Arg Thr Gly Gln Val Pro Asn Cys Ala Val Pro Cys Tyr Gln 
    210                 215                 220                 


Pro Ser Phe Ser Ala Asp Glu Arg Thr Phe Ala Thr Phe Trp Ile Gly 
225                 230                 235                 240 


Leu Trp Ser Val Leu Cys Phe Ile Ser Thr Ser Thr Thr Val Ala Thr 
                245                 250                 255     


Phe Leu Ile Asp Met Glu Arg Phe Arg Tyr Pro Glu Arg Pro Ile Ile 
            260                 265                 270         


Phe Leu Ser Ala Cys Tyr Leu Cys Val Ser Leu Gly Phe Leu Val Arg 
        275                 280                 285             


Leu Val Val Gly His Ala Ser Val Ala Cys Ser Arg Glu His Asn His 
    290                 295                 300                 


Ile His Tyr Glu Thr Thr Gly Pro Ala Leu Cys Thr Ile Val Phe Leu 
305                 310                 315                 320 


Leu Val Tyr Phe Phe Gly Met Ala Ser Ser Ile Trp Trp Val Ile Leu 
                325                 330                 335     


Ser Leu Thr Trp Phe Leu Ala Ala Gly Met Lys Trp Gly Asn Glu Ala 
            340                 345                 350         


Ile Ala Gly Tyr Ala Gln Tyr Phe His Leu Ala Ala Trp Leu Ile Pro 
        355                 360                 365             


Ser Val Lys Ser Ile Thr Ala Leu Ala Leu Ser Ser Val Asp Gly Asp 
    370                 375                 380                 


Pro Val Ala Gly Ile Cys Tyr Val Gly Asn Gln Asn Leu Asn Ser Leu 
385                 390                 395                 400 


Arg Gly Phe Val Leu Gly Pro Leu Val Leu Tyr Leu Leu Val Gly Thr 
                405                 410                 415     


Leu Phe Leu Leu Ala Gly Phe Val Ser Leu Phe Arg Ile Arg Ser Val 
            420                 425                 430         


Ile Lys Gln Gly Gly Thr Lys Thr Asp Lys Leu Glu Lys Leu Met Ile 
        435                 440                 445             


Arg Ile Gly Ile Phe Thr Leu Leu Tyr Thr Val Pro Ala Ser Ile Val 
    450                 455                 460                 


Val Ala Cys Tyr Leu Tyr Glu Gln His Tyr Arg Glu Ser Trp Glu Ala 
465                 470                 475                 480 


Ala Leu Thr Cys Ala Cys Pro Gly His Asp Thr Gly Gln Pro Arg Ala 
                485                 490                 495     


Lys Pro Glu Tyr Trp Val Leu Met Leu Lys Tyr Phe Met Cys Leu Val 
            500                 505                 510         


Val Gly Ile Thr Ser Gly Val Trp Ile Trp Ser Gly Lys Thr Val Glu 
        515                 520                 525             


Ser Trp Arg Arg Phe Thr Ser Arg Cys Cys Cys Arg Pro Arg Arg Gly 
    530                 535                 540                 


His Lys Ser Gly Gly Ala Met Ala Ala Gly Asp Tyr Pro Glu Ala Ser 
545                 550                 555                 560 


Ala Ala Leu Thr Gly Arg Thr Gly Pro Pro Gly Pro Ala Ala Thr Tyr 
                565                 570                 575     


His Lys Gln Val Ser Leu Ser His Val 
            580                 585 


<210>  2838
<211>  617
<212>  PRT
<213>  Homo sapiens

<400>  2838

Met Ala Glu Ala Lys Thr His Trp Leu Gly Ala Ala Leu Ser Leu Ile 
1               5                   10                  15      


Pro Leu Ile Phe Leu Ile Ser Gly Ala Glu Ala Ala Ser Phe Gln Arg 
            20                  25                  30          


Asn Gln Leu Leu Gln Lys Glu Pro Asp Leu Arg Leu Glu Asn Val Gln 
        35                  40                  45              


Lys Phe Pro Ser Pro Glu Met Ile Arg Ala Leu Glu Tyr Ile Glu Asn 
    50                  55                  60                  


Leu Arg Gln Gln Ala His Lys Glu Glu Ser Ser Pro Asp Tyr Asn Pro 
65                  70                  75                  80  


Tyr Gln Gly Val Ser Val Pro Leu Gln Gln Lys Glu Asn Gly Asp Glu 
                85                  90                  95      


Ser His Leu Pro Glu Arg Asp Ser Leu Ser Glu Glu Asp Trp Met Arg 
            100                 105                 110         


Ile Ile Leu Glu Ala Leu Arg Gln Ala Glu Asn Glu Pro Gln Ser Ala 
        115                 120                 125             


Pro Lys Glu Asn Lys Pro Tyr Ala Leu Asn Ser Glu Lys Asn Phe Pro 
    130                 135                 140                 


Met Asp Met Ser Asp Asp Tyr Glu Thr Gln Gln Trp Pro Glu Arg Lys 
145                 150                 155                 160 


Leu Lys His Met Gln Phe Pro Pro Met Tyr Glu Glu Asn Ser Arg Asp 
                165                 170                 175     


Asn Pro Phe Lys Arg Thr Asn Glu Ile Val Glu Glu Gln Tyr Thr Pro 
            180                 185                 190         


Gln Ser Leu Ala Thr Leu Glu Ser Val Phe Gln Glu Leu Gly Lys Leu 
        195                 200                 205             


Thr Gly Pro Asn Asn Gln Lys Arg Glu Arg Met Asp Glu Glu Gln Lys 
    210                 215                 220                 


Leu Tyr Thr Asp Asp Glu Asp Asp Ile Tyr Lys Ala Asn Asn Ile Ala 
225                 230                 235                 240 


Tyr Glu Asp Val Val Gly Gly Glu Asp Trp Asn Pro Val Glu Glu Lys 
                245                 250                 255     


Ile Glu Ser Gln Thr Gln Glu Glu Val Arg Asp Ser Lys Glu Asn Ile 
            260                 265                 270         


Glu Lys Asn Glu Gln Ile Asn Asp Glu Met Lys Arg Ser Gly Gln Leu 
        275                 280                 285             


Gly Ile Gln Glu Glu Asp Leu Arg Lys Glu Ser Lys Asp Gln Leu Ser 
    290                 295                 300                 


Asp Asp Val Ser Lys Val Ile Ala Tyr Leu Lys Arg Leu Val Asn Ala 
305                 310                 315                 320 


Ala Gly Ser Gly Arg Leu Gln Asn Gly Gln Asn Gly Glu Arg Ala Thr 
                325                 330                 335     


Arg Leu Phe Glu Lys Pro Leu Asp Ser Gln Ser Ile Tyr Gln Leu Ile 
            340                 345                 350         


Glu Ile Ser Arg Asn Leu Gln Ile Pro Pro Glu Asp Leu Ile Glu Met 
        355                 360                 365             


Leu Lys Thr Gly Glu Lys Pro Asn Gly Ser Val Glu Pro Glu Arg Glu 
    370                 375                 380                 


Leu Asp Leu Pro Val Asp Leu Asp Asp Ile Ser Glu Ala Asp Leu Asp 
385                 390                 395                 400 


His Pro Asp Leu Phe Gln Asn Arg Met Leu Ser Lys Ser Gly Tyr Pro 
                405                 410                 415     


Lys Thr Pro Gly Arg Ala Gly Thr Glu Ala Leu Pro Asp Gly Leu Ser 
            420                 425                 430         


Val Glu Asp Ile Leu Asn Leu Leu Gly Met Glu Ser Ala Ala Asn Gln 
        435                 440                 445             


Lys Thr Ser Tyr Phe Pro Asn Pro Tyr Asn Gln Glu Lys Val Leu Pro 
    450                 455                 460                 


Arg Leu Pro Tyr Gly Ala Gly Arg Ser Arg Ser Asn Gln Leu Pro Lys 
465                 470                 475                 480 


Ala Ala Trp Ile Pro His Val Glu Asn Arg Gln Met Ala Tyr Glu Asn 
                485                 490                 495     


Leu Asn Asp Lys Asp Gln Glu Leu Gly Glu Tyr Leu Ala Arg Met Leu 
            500                 505                 510         


Val Lys Tyr Pro Glu Ile Ile Asn Ser Asn Gln Val Lys Arg Val Pro 
        515                 520                 525             


Gly Gln Gly Ser Ser Glu Asp Asp Leu Gln Glu Glu Glu Gln Ile Glu 
    530                 535                 540                 


Gln Ala Ile Lys Glu His Leu Asn Gln Gly Ser Ser Gln Glu Thr Asp 
545                 550                 555                 560 


Lys Leu Ala Pro Val Ser Lys Arg Phe Pro Val Gly Pro Pro Lys Asn 
                565                 570                 575     


Asp Asp Thr Pro Asn Arg Gln Tyr Trp Asp Glu Asp Leu Leu Met Lys 
            580                 585                 590         


Val Leu Glu Tyr Leu Asn Gln Glu Lys Ala Glu Lys Gly Arg Glu His 
        595                 600                 605             


Ile Ala Lys Arg Ala Met Glu Asn Met 
    610                 615         


<210>  2839
<211>  909
<212>  PRT
<213>  Homo sapiens

<400>  2839

Met Ala Ala Arg Pro Leu Pro Val Ser Pro Ala Arg Ala Leu Leu Leu 
1               5                   10                  15      


Ala Leu Ala Gly Ala Leu Leu Ala Pro Cys Glu Ala Arg Gly Val Ser 
            20                  25                  30          


Leu Trp Asn Gln Gly Arg Ala Asp Glu Val Val Ser Ala Ser Val Gly 
        35                  40                  45              


Ser Gly Asp Leu Trp Ile Pro Val Lys Ser Phe Asp Ser Lys Asn His 
    50                  55                  60                  


Pro Glu Val Leu Asn Ile Arg Leu Gln Arg Glu Ser Lys Glu Leu Ile 
65                  70                  75                  80  


Ile Asn Leu Glu Arg Asn Glu Gly Leu Ile Ala Ser Ser Phe Thr Glu 
                85                  90                  95      


Thr His Tyr Leu Gln Asp Gly Thr Asp Val Ser Leu Ala Arg Asn Tyr 
            100                 105                 110         


Thr Val Ile Leu Gly His Cys Tyr Tyr His Gly His Val Arg Gly Tyr 
        115                 120                 125             


Ser Asp Ser Ala Val Ser Leu Ser Thr Cys Ser Gly Leu Arg Gly Leu 
    130                 135                 140                 


Ile Val Phe Glu Asn Glu Ser Tyr Val Leu Glu Pro Met Lys Ser Ala 
145                 150                 155                 160 


Thr Asn Arg Tyr Lys Leu Phe Pro Ala Lys Lys Leu Lys Ser Val Arg 
                165                 170                 175     


Gly Ser Cys Gly Ser His His Asn Thr Pro Asn Leu Ala Ala Lys Asn 
            180                 185                 190         


Val Phe Pro Pro Pro Ser Gln Thr Trp Ala Arg Arg His Lys Arg Glu 
        195                 200                 205             


Thr Leu Lys Ala Thr Lys Tyr Val Glu Leu Val Ile Val Ala Asp Asn 
    210                 215                 220                 


Arg Glu Phe Gln Arg Gln Gly Lys Asp Leu Glu Lys Val Lys Gln Arg 
225                 230                 235                 240 


Leu Ile Glu Ile Ala Asn His Val Asp Lys Phe Tyr Arg Pro Leu Asn 
                245                 250                 255     


Ile Arg Ile Val Leu Val Gly Val Glu Val Trp Asn Asp Met Asp Lys 
            260                 265                 270         


Cys Ser Val Ser Gln Asp Pro Phe Thr Ser Leu His Glu Phe Leu Asp 
        275                 280                 285             


Trp Arg Lys Met Lys Leu Leu Pro Arg Lys Ser His Asp Asn Ala Gln 
    290                 295                 300                 


Leu Val Ser Gly Val Tyr Phe Gln Gly Thr Thr Ile Gly Met Ala Pro 
305                 310                 315                 320 


Ile Met Ser Met Cys Thr Ala Asp Gln Ser Gly Gly Ile Val Met Asp 
                325                 330                 335     


His Ser Asp Asn Pro Leu Gly Ala Ala Val Thr Leu Ala His Glu Leu 
            340                 345                 350         


Gly His Asn Phe Gly Met Asn His Asp Thr Leu Asp Arg Gly Cys Ser 
        355                 360                 365             


Cys Gln Met Ala Val Glu Lys Gly Gly Cys Ile Met Asn Ala Ser Thr 
    370                 375                 380                 


Gly Tyr Pro Phe Pro Met Val Phe Ser Ser Cys Ser Arg Lys Asp Leu 
385                 390                 395                 400 


Glu Thr Ser Leu Glu Lys Gly Met Gly Val Cys Leu Phe Asn Leu Pro 
                405                 410                 415     


Glu Val Arg Glu Ser Phe Gly Gly Gln Lys Cys Gly Asn Arg Phe Val 
            420                 425                 430         


Glu Glu Gly Glu Glu Cys Asp Cys Gly Glu Pro Glu Glu Cys Met Asn 
        435                 440                 445             


Arg Cys Cys Asn Ala Thr Thr Cys Thr Leu Lys Pro Asp Ala Val Cys 
    450                 455                 460                 


Ala His Gly Leu Cys Cys Glu Asp Cys Gln Leu Lys Pro Ala Gly Thr 
465                 470                 475                 480 


Ala Cys Arg Asp Ser Ser Asn Ser Cys Asp Leu Pro Glu Phe Cys Thr 
                485                 490                 495     


Gly Ala Ser Pro His Cys Pro Ala Asn Val Tyr Leu His Asp Gly His 
            500                 505                 510         


Ser Cys Gln Asp Val Asp Gly Tyr Cys Tyr Asn Gly Ile Cys Gln Thr 
        515                 520                 525             


His Glu Gln Gln Cys Val Thr Leu Trp Gly Pro Gly Ala Lys Pro Ala 
    530                 535                 540                 


Pro Gly Ile Cys Phe Glu Arg Val Asn Ser Ala Gly Asp Pro Tyr Gly 
545                 550                 555                 560 


Asn Cys Gly Lys Val Ser Lys Ser Ser Phe Ala Lys Cys Glu Met Arg 
                565                 570                 575     


Asp Ala Lys Cys Gly Lys Ile Gln Cys Gln Gly Gly Ala Ser Arg Pro 
            580                 585                 590         


Val Ile Gly Thr Asn Ala Val Ser Ile Glu Thr Asn Ile Pro Leu Gln 
        595                 600                 605             


Gln Gly Gly Arg Ile Leu Cys Arg Gly Thr His Val Tyr Leu Gly Asp 
    610                 615                 620                 


Asp Met Pro Asp Pro Gly Leu Val Leu Ala Gly Thr Lys Cys Ala Asp 
625                 630                 635                 640 


Gly Lys Ile Cys Leu Asn Arg Gln Cys Gln Asn Ile Ser Val Phe Gly 
                645                 650                 655     


Val His Glu Cys Ala Met Gln Cys His Gly Arg Gly Val Cys Asn Asn 
            660                 665                 670         


Arg Lys Asn Cys His Cys Glu Ala His Trp Ala Pro Pro Phe Cys Asp 
        675                 680                 685             


Lys Phe Gly Phe Gly Gly Ser Thr Asp Ser Gly Pro Ile Arg Gln Ala 
    690                 695                 700                 


Asp Asn Gln Gly Leu Thr Ile Gly Ile Leu Val Thr Ile Leu Cys Leu 
705                 710                 715                 720 


Leu Ala Ala Gly Phe Val Val Tyr Leu Lys Arg Lys Thr Leu Ile Arg 
                725                 730                 735     


Leu Leu Phe Thr Asn Lys Lys Thr Thr Ile Glu Lys Leu Arg Cys Val 
            740                 745                 750         


Arg Pro Ser Arg Pro Pro Arg Gly Phe Gln Pro Cys Gln Ala His Leu 
        755                 760                 765             


Gly His Leu Gly Lys Gly Leu Met Arg Lys Pro Pro Asp Ser Tyr Pro 
    770                 775                 780                 


Pro Lys Asp Asn Pro Arg Arg Leu Leu Gln Cys Gln Asn Val Asp Ile 
785                 790                 795                 800 


Ser Arg Pro Leu Asn Gly Leu Asn Val Pro Gln Pro Gln Ser Thr Gln 
                805                 810                 815     


Arg Val Leu Pro Pro Leu His Arg Ala Pro Arg Ala Pro Ser Val Pro 
            820                 825                 830         


Ala Arg Pro Leu Pro Ala Lys Pro Ala Leu Arg Gln Ala Gln Gly Thr 
        835                 840                 845             


Cys Lys Pro Asn Pro Pro Gln Lys Pro Leu Pro Ala Asp Pro Leu Ala 
    850                 855                 860                 


Arg Thr Thr Arg Leu Thr His Ala Leu Ala Arg Thr Pro Gly Gln Trp 
865                 870                 875                 880 


Glu Thr Gly Leu Arg Leu Ala Pro Leu Arg Pro Ala Pro Gln Tyr Pro 
                885                 890                 895     


His Gln Val Pro Arg Ser Thr His Thr Ala Tyr Ile Lys 
            900                 905                 


<210>  2840
<211>  903
<212>  PRT
<213>  Homo sapiens

<400>  2840

Met Ala Ile Gln Phe Arg Ser Leu Phe Pro Leu Ala Leu Pro Gly Met 
1               5                   10                  15      


Leu Ala Leu Leu Gly Trp Trp Trp Phe Phe Ser Arg Lys Lys Gly His 
            20                  25                  30          


Val Ser Ser His Asp Glu Gln Gln Val Glu Ala Gly Ala Val Gln Leu 
        35                  40                  45              


Arg Ala Asp Pro Ala Ile Lys Glu Pro Leu Pro Val Glu Asp Val Cys 
    50                  55                  60                  


Pro Lys Val Val Ser Thr Pro Pro Ser Val Thr Glu Pro Pro Glu Lys 
65                  70                  75                  80  


Glu Leu Ser Thr Val Ser Lys Leu Pro Ala Glu Pro Pro Ala Leu Leu 
                85                  90                  95      


Gln Thr His Pro Pro Cys Arg Arg Ser Glu Ser Ser Gly Ile Leu Pro 
            100                 105                 110         


Asn Thr Thr Asp Met Arg Leu Arg Pro Gly Thr Arg Arg Asp Asp Ser 
        115                 120                 125             


Thr Lys Leu Glu Leu Ala Leu Thr Gly Gly Glu Ala Lys Ser Ile Pro 
    130                 135                 140                 


Leu Glu Cys Pro Leu Ser Ser Pro Lys Gly Val Leu Phe Ser Ser Lys 
145                 150                 155                 160 


Ser Ala Glu Val Cys Lys Gln Asp Ser Pro Phe Ser Arg Val Pro Arg 
                165                 170                 175     


Lys Val Gln Pro Gly Tyr Pro Val Val Pro Ala Glu Lys Arg Ser Ser 
            180                 185                 190         


Gly Glu Arg Ala Arg Glu Thr Gly Gly Ala Glu Gly Thr Gly Asp Ala 
        195                 200                 205             


Val Leu Gly Glu Lys Val Leu Glu Glu Ala Leu Leu Ser Arg Glu His 
    210                 215                 220                 


Val Leu Glu Leu Glu Asn Ser Lys Gly Pro Ser Leu Ala Ser Leu Glu 
225                 230                 235                 240 


Gly Glu Glu Asp Lys Gly Lys Ser Ser Ser Ser Gln Val Val Gly Pro 
                245                 250                 255     


Val Gln Glu Glu Glu Tyr Val Ala Glu Lys Leu Pro Ser Arg Phe Ile 
            260                 265                 270         


Glu Ser Ala His Thr Glu Leu Ala Lys Asp Asp Ala Ala Pro Ala Pro 
        275                 280                 285             


Pro Val Ala Asp Ala Lys Ala Gln Asp Arg Gly Val Glu Gly Glu Leu 
    290                 295                 300                 


Gly Asn Glu Glu Ser Leu Asp Arg Asn Glu Glu Gly Leu Asp Arg Asn 
305                 310                 315                 320 


Glu Glu Gly Leu Asp Arg Asn Glu Glu Ser Leu Asp Arg Asn Glu Glu 
                325                 330                 335     


Gly Leu Asp Arg Asn Glu Glu Ile Lys Arg Ala Ala Phe Gln Ile Ile 
            340                 345                 350         


Ser Gln Val Ile Ser Glu Ala Thr Glu Gln Val Leu Ala Thr Thr Val 
        355                 360                 365             


Gly Lys Val Ala Gly Arg Val Cys Gln Ala Ser Gln Leu Gln Gly Gln 
    370                 375                 380                 


Lys Glu Glu Ser Cys Val Pro Val His Gln Lys Thr Val Leu Gly Pro 
385                 390                 395                 400 


Asp Thr Ala Glu Pro Ala Thr Ala Glu Ala Ala Val Ala Pro Pro Asp 
                405                 410                 415     


Ala Gly Leu Pro Leu Pro Gly Leu Pro Ala Glu Gly Ser Pro Pro Pro 
            420                 425                 430         


Lys Thr Tyr Val Ser Cys Leu Lys Ser Leu Leu Ser Ser Pro Thr Lys 
        435                 440                 445             


Asp Ser Lys Pro Asn Ile Ser Ala His His Ile Ser Leu Ala Ser Cys 
    450                 455                 460                 


Leu Ala Leu Thr Thr Pro Ser Glu Glu Leu Pro Asp Arg Ala Gly Ile 
465                 470                 475                 480 


Leu Val Glu Asp Ala Thr Cys Val Thr Cys Met Ser Asp Ser Ser Gln 
                485                 490                 495     


Ser Val Pro Leu Val Ala Ser Pro Gly His Cys Ser Asp Ser Phe Ser 
            500                 505                 510         


Thr Ser Gly Leu Glu Asp Ser Cys Thr Glu Thr Ser Ser Ser Pro Arg 
        515                 520                 525             


Asp Lys Ala Ile Thr Pro Pro Leu Pro Glu Ser Thr Val Pro Phe Ser 
    530                 535                 540                 


Asn Gly Val Leu Lys Gly Glu Leu Ser Asp Leu Gly Ala Glu Asp Gly 
545                 550                 555                 560 


Trp Thr Met Asp Ala Glu Ala Asp His Ser Gly Gly Ser Asp Arg Asn 
                565                 570                 575     


Ser Met Asp Ser Val Asp Ser Cys Cys Ser Leu Lys Lys Thr Glu Ser 
            580                 585                 590         


Phe Gln Asn Ala Gln Ala Gly Ser Asn Pro Lys Lys Val Asp Leu Ile 
        595                 600                 605             


Ile Trp Glu Ile Glu Val Pro Lys His Leu Val Gly Arg Leu Ile Gly 
    610                 615                 620                 


Lys Gln Gly Arg Tyr Val Ser Phe Leu Lys Gln Thr Ser Gly Ala Lys 
625                 630                 635                 640 


Ile Tyr Ile Ser Thr Leu Pro Tyr Thr Gln Ser Val Gln Ile Cys His 
                645                 650                 655     


Ile Glu Gly Ser Gln His His Val Asp Lys Ala Leu Asn Leu Ile Gly 
            660                 665                 670         


Lys Lys Phe Lys Glu Leu Asn Leu Thr Asn Ile Tyr Ala Pro Pro Leu 
        675                 680                 685             


Pro Ser Leu Ala Leu Pro Ser Leu Pro Met Thr Ser Trp Leu Met Leu 
    690                 695                 700                 


Pro Asp Gly Ile Thr Val Glu Val Ile Val Val Asn Gln Val Asn Ala 
705                 710                 715                 720 


Gly His Leu Phe Val Gln Gln His Thr His Pro Thr Phe His Ala Leu 
                725                 730                 735     


Arg Ser Leu Asp Gln Gln Met Tyr Leu Cys Tyr Ser Gln Pro Gly Ile 
            740                 745                 750         


Pro Thr Leu Pro Thr Pro Val Glu Ile Thr Val Ile Cys Ala Ala Pro 
        755                 760                 765             


Gly Ala Asp Gly Ala Trp Trp Arg Ala Gln Val Val Ala Ser Tyr Glu 
    770                 775                 780                 


Glu Thr Asn Glu Val Glu Ile Arg Tyr Val Asp Tyr Gly Gly Tyr Lys 
785                 790                 795                 800 


Arg Val Lys Val Asp Val Leu Arg Gln Ile Arg Ser Asp Phe Val Thr 
                805                 810                 815     


Leu Pro Phe Gln Gly Ala Glu Val Leu Leu Asp Ser Val Met Pro Leu 
            820                 825                 830         


Ser Asp Asp Asp Gln Phe Ser Pro Glu Ala Asp Ala Ala Met Ser Glu 
        835                 840                 845             


Met Thr Gly Asn Thr Ala Leu Leu Ala Gln Val Thr Ser Tyr Ser Pro 
    850                 855                 860                 


Thr Gly Leu Pro Leu Ile Gln Leu Trp Ser Val Val Gly Asp Glu Val 
865                 870                 875                 880 


Val Leu Ile Asn Arg Ser Leu Val Glu Arg Gly Leu Ala Gln Trp Val 
                885                 890                 895     


Asp Ser Tyr Tyr Thr Ser Leu 
            900             


<210>  2841
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  2841

Met Asn Pro Glu Trp Gly Gln Ala Phe Val His Val Ala Val Ala Gly 
1               5                   10                  15      


Gly Leu Cys Ala Val Ala Val Phe Thr Gly Ile Phe Asp Ser Val Ser 
            20                  25                  30          


Val Gln Val Gly Tyr Glu His Tyr Ala Glu Ala Pro Val Ala Gly Leu 
        35                  40                  45              


Pro Ala Phe Leu Ala Met Pro Phe Asn Ser Leu Val Asn Met Ala Tyr 
    50                  55                  60                  


Thr Leu Leu Gly Leu Ser Trp Leu His Arg Gly Gly Ala Met Gly Leu 
65                  70                  75                  80  


Gly Pro Arg Tyr Leu Lys Asp Val Phe Ala Ala Met Ala Leu Leu Tyr 
                85                  90                  95      


Gly Pro Val Gln Trp Leu Arg Leu Trp Thr Gln Trp Arg Arg Ala Ala 
            100                 105                 110         


Val Leu Asp Gln Trp Leu Thr Leu Pro Ile Phe Ala Trp Pro Val Ala 
        115                 120                 125             


Trp Cys Leu Tyr Leu Asp Arg Gly Trp Arg Pro Trp Leu Phe Leu Ser 
    130                 135                 140                 


Leu Glu Cys Val Ser Leu Ala Ser Tyr Gly Leu Ala Leu Leu His Pro 
145                 150                 155                 160 


Gln Gly Phe Glu Val Ala Leu Gly Ala His Val Val Ala Ala Val Gly 
                165                 170                 175     


Gln Ala Leu Arg Thr His Arg His Tyr Gly Ser Thr Thr Ser Ala Thr 
            180                 185                 190         


Tyr Leu Ala Leu Gly Val Leu Ser Cys Leu Gly Phe Val Val Leu Lys 
        195                 200                 205             


Leu Cys Asp His Gln Leu Ala Arg Trp Arg Leu Phe Gln Cys Leu Thr 
    210                 215                 220                 


Gly His Phe Trp Ser Lys Val Cys Asp Val Leu Gln Phe His Phe Ala 
225                 230                 235                 240 


Phe Leu Phe Leu Thr His Phe Asn Thr His Pro Arg Phe His Pro Ser 
                245                 250                 255     


Gly Gly Lys Thr Arg 
            260     


<210>  2842
<211>  2080
<212>  PRT
<213>  Homo sapiens

<400>  2842

Met Leu Arg Val Phe Ile Leu Tyr Ala Glu Asn Val His Thr Pro Asp 
1               5                   10                  15      


Thr Asp Ile Ser Asp Ala Tyr Cys Ser Ala Val Phe Ala Gly Val Lys 
            20                  25                  30          


Lys Arg Thr Lys Val Ile Lys Asn Ser Val Asn Pro Val Trp Asn Glu 
        35                  40                  45              


Gly Phe Glu Trp Asp Leu Lys Gly Ile Pro Leu Asp Gln Gly Ser Glu 
    50                  55                  60                  


Leu His Val Val Val Lys Asp His Glu Thr Met Gly Arg Asn Arg Phe 
65                  70                  75                  80  


Leu Gly Glu Ala Lys Val Pro Leu Arg Glu Val Leu Ala Thr Pro Ser 
                85                  90                  95      


Leu Ser Ala Ser Phe Asn Ala Pro Leu Leu Asp Thr Lys Lys Gln Pro 
            100                 105                 110         


Thr Gly Ala Ser Leu Val Leu Gln Val Ser Tyr Thr Pro Leu Pro Gly 
        115                 120                 125             


Ala Val Pro Leu Phe Pro Pro Pro Thr Pro Leu Glu Pro Ser Pro Thr 
    130                 135                 140                 


Leu Pro Asp Leu Asp Val Val Ala Asp Thr Gly Gly Glu Glu Asp Thr 
145                 150                 155                 160 


Glu Asp Gln Gly Leu Thr Gly Asp Glu Ala Glu Pro Phe Leu Asp Gln 
                165                 170                 175     


Ser Gly Gly Pro Gly Ala Pro Thr Thr Pro Arg Lys Leu Pro Ser Arg 
            180                 185                 190         


Pro Pro Pro His Tyr Pro Gly Ile Lys Arg Lys Arg Ser Ala Pro Thr 
        195                 200                 205             


Ser Arg Lys Leu Leu Ser Asp Lys Pro Gln Asp Phe Gln Ile Arg Val 
    210                 215                 220                 


Gln Val Ile Glu Gly Arg Gln Leu Pro Gly Val Asn Ile Lys Pro Val 
225                 230                 235                 240 


Val Lys Val Thr Ala Ala Gly Gln Thr Lys Arg Thr Arg Ile His Lys 
                245                 250                 255     


Gly Asn Ser Pro Leu Phe Asn Glu Thr Leu Phe Phe Asn Leu Phe Asp 
            260                 265                 270         


Ser Pro Gly Glu Leu Phe Asp Glu Pro Ile Phe Ile Thr Val Val Asp 
        275                 280                 285             


Ser Arg Ser Leu Arg Thr Asp Ala Leu Leu Gly Glu Phe Arg Met Asp 
    290                 295                 300                 


Val Gly Thr Ile Tyr Arg Glu Pro Arg His Ala Tyr Leu Arg Lys Trp 
305                 310                 315                 320 


Leu Leu Leu Ser Asp Pro Asp Asp Phe Ser Ala Gly Ala Arg Gly Tyr 
                325                 330                 335     


Leu Lys Thr Ser Leu Cys Val Leu Gly Pro Gly Asp Glu Ala Pro Leu 
            340                 345                 350         


Glu Arg Lys Asp Pro Ser Glu Asp Lys Glu Asp Ile Glu Ser Asn Leu 
        355                 360                 365             


Leu Arg Pro Thr Gly Val Ala Leu Arg Gly Ala His Phe Cys Leu Lys 
    370                 375                 380                 


Val Phe Arg Ala Glu Asp Leu Pro Gln Met Asp Asp Ala Val Met Asp 
385                 390                 395                 400 


Asn Val Lys Gln Ile Phe Gly Phe Glu Ser Asn Lys Lys Asn Leu Val 
                405                 410                 415     


Asp Pro Phe Val Glu Val Ser Phe Ala Gly Lys Met Leu Cys Ser Lys 
            420                 425                 430         


Ile Leu Glu Lys Thr Ala Asn Pro Gln Trp Asn Gln Asn Ile Thr Leu 
        435                 440                 445             


Pro Ala Met Phe Pro Ser Met Cys Glu Lys Met Arg Ile Arg Ile Ile 
    450                 455                 460                 


Asp Trp Asp Arg Leu Thr His Asn Asp Ile Val Ala Thr Thr Tyr Leu 
465                 470                 475                 480 


Ser Met Ser Lys Ile Ser Ala Pro Gly Gly Glu Ile Glu Glu Glu Pro 
                485                 490                 495     


Ala Gly Ala Val Lys Pro Ser Lys Ala Ser Asp Leu Asp Asp Tyr Leu 
            500                 505                 510         


Gly Phe Leu Pro Thr Phe Gly Pro Cys Tyr Ile Asn Leu Tyr Gly Ser 
        515                 520                 525             


Pro Arg Glu Phe Thr Gly Phe Pro Asp Pro Tyr Thr Glu Leu Asn Thr 
    530                 535                 540                 


Gly Lys Gly Glu Gly Val Ala Tyr Arg Gly Arg Leu Leu Leu Ser Leu 
545                 550                 555                 560 


Glu Thr Lys Leu Val Glu His Ser Glu Gln Lys Val Glu Asp Leu Pro 
                565                 570                 575     


Ala Asp Asp Ile Leu Arg Val Glu Lys Tyr Leu Arg Arg Arg Lys Tyr 
            580                 585                 590         


Ser Leu Phe Ala Ala Phe Tyr Ser Ala Thr Met Leu Gln Asp Val Asp 
        595                 600                 605             


Asp Ala Ile Gln Phe Glu Val Ser Ile Gly Asn Tyr Gly Asn Lys Phe 
    610                 615                 620                 


Asp Met Thr Cys Leu Pro Leu Ala Ser Thr Thr Gln Tyr Ser Arg Ala 
625                 630                 635                 640 


Val Phe Asp Gly Cys His Tyr Tyr Tyr Leu Pro Trp Gly Asn Val Lys 
                645                 650                 655     


Pro Val Val Val Leu Ser Ser Tyr Trp Glu Asp Ile Ser His Arg Ile 
            660                 665                 670         


Glu Thr Gln Asn Gln Leu Leu Gly Ile Ala Asp Arg Leu Glu Ala Gly 
        675                 680                 685             


Leu Glu Gln Val His Leu Ala Leu Lys Ala Gln Cys Ser Thr Glu Asp 
    690                 695                 700                 


Val Asp Ser Leu Val Ala Gln Leu Thr Asp Glu Leu Ile Ala Gly Cys 
705                 710                 715                 720 


Ser Gln Pro Leu Gly Asp Ile His Glu Thr Pro Ser Ala Thr His Leu 
                725                 730                 735     


Asp Gln Tyr Leu Tyr Gln Leu Arg Thr His His Leu Ser Gln Ile Thr 
            740                 745                 750         


Glu Ala Ala Leu Ala Leu Lys Leu Gly His Ser Glu Leu Pro Ala Ala 
        755                 760                 765             


Leu Glu Gln Ala Glu Asp Trp Leu Leu Arg Leu Arg Ala Leu Ala Glu 
    770                 775                 780                 


Glu Pro Gln Asn Ser Leu Pro Asp Ile Val Ile Trp Met Leu Gln Gly 
785                 790                 795                 800 


Asp Lys Arg Val Ala Tyr Gln Arg Val Pro Ala His Gln Val Leu Phe 
                805                 810                 815     


Ser Arg Arg Gly Ala Asn Tyr Cys Gly Lys Asn Cys Gly Lys Leu Gln 
            820                 825                 830         


Thr Ile Phe Leu Lys Tyr Pro Met Glu Lys Val Pro Gly Ala Arg Met 
        835                 840                 845             


Pro Val Gln Ile Arg Val Lys Leu Trp Phe Gly Leu Ser Val Asp Glu 
    850                 855                 860                 


Lys Glu Phe Asn Gln Phe Ala Glu Gly Lys Leu Ser Val Phe Ala Glu 
865                 870                 875                 880 


Thr Tyr Glu Asn Glu Thr Lys Leu Ala Leu Val Gly Asn Trp Gly Thr 
                885                 890                 895     


Thr Gly Leu Thr Tyr Pro Lys Phe Ser Asp Val Thr Gly Lys Ile Lys 
            900                 905                 910         


Leu Pro Lys Asp Ser Phe Arg Pro Ser Ala Gly Trp Thr Trp Ala Gly 
        915                 920                 925             


Asp Trp Phe Val Cys Pro Glu Lys Thr Leu Leu His Asp Met Asp Ala 
    930                 935                 940                 


Gly His Leu Ser Phe Val Glu Glu Val Phe Glu Asn Gln Thr Arg Leu 
945                 950                 955                 960 


Pro Gly Gly Gln Trp Ile Tyr Met Ser Asp Asn Tyr Thr Asp Val Asn 
                965                 970                 975     


Gly Glu Lys Val Leu Pro Lys Asp Asp Ile Glu Cys Pro Leu Gly Trp 
            980                 985                 990         


Lys Trp Glu Asp Glu Glu Trp Ser  Thr Asp Leu Asn Arg  Ala Val Asp 
        995                 1000                 1005             


Glu Gln  Gly Trp Glu Tyr Ser  Ile Thr Ile Pro Pro  Glu Arg Lys 
    1010                 1015                 1020             


Pro Lys  His Trp Val Pro Ala  Glu Lys Met Tyr Tyr  Thr His Arg 
    1025                 1030                 1035             


Arg Arg  Arg Trp Val Arg Leu  Arg Arg Arg Asp Leu  Ser Gln Met 
    1040                 1045                 1050             


Glu Ala  Leu Lys Arg His Arg  Gln Ala Glu Ala Glu  Gly Glu Gly 
    1055                 1060                 1065             


Trp Glu  Tyr Ala Ser Leu Phe  Gly Trp Lys Phe His  Leu Glu Tyr 
    1070                 1075                 1080             


Arg Lys  Thr Asp Ala Phe Arg  Arg Arg Arg Trp Arg  Arg Arg Met 
    1085                 1090                 1095             


Glu Pro  Leu Glu Lys Thr Gly  Pro Ala Ala Val Phe  Ala Leu Glu 
    1100                 1105                 1110             


Gly Ala  Leu Gly Gly Val Met  Asp Asp Lys Ser Glu  Asp Ser Met 
    1115                 1120                 1125             


Ser Val  Ser Thr Leu Ser Phe  Gly Val Asn Arg Pro  Thr Ile Ser 
    1130                 1135                 1140             


Cys Ile  Phe Asp Tyr Gly Asn  Arg Tyr His Leu Arg  Cys Tyr Met 
    1145                 1150                 1155             


Tyr Gln  Ala Arg Asp Leu Ala  Ala Met Asp Lys Asp  Ser Phe Ser 
    1160                 1165                 1170             


Asp Pro  Tyr Ala Ile Val Ser  Phe Leu His Gln Ser  Gln Lys Thr 
    1175                 1180                 1185             


Val Val  Val Lys Asn Thr Leu  Asn Pro Thr Trp Asp  Gln Thr Leu 
    1190                 1195                 1200             


Ile Phe  Tyr Glu Ile Glu Ile  Phe Gly Glu Pro Ala  Thr Val Ala 
    1205                 1210                 1215             


Glu Gln  Pro Pro Ser Ile Val  Val Glu Leu Tyr Asp  His Asp Thr 
    1220                 1225                 1230             


Tyr Gly  Ala Asp Glu Phe Met  Gly Arg Cys Ile Cys  Gln Pro Ser 
    1235                 1240                 1245             


Leu Glu  Arg Met Pro Arg Leu  Ala Trp Phe Pro Leu  Thr Arg Gly 
    1250                 1255                 1260             


Ser Gln  Pro Ser Gly Glu Leu  Leu Ala Ser Phe Glu  Leu Ile Gln 
    1265                 1270                 1275             


Arg Glu  Lys Pro Ala Ile His  His Ile Pro Gly Phe  Glu Val Gln 
    1280                 1285                 1290             


Glu Thr  Ser Arg Ile Leu Asp  Glu Ser Glu Asp Thr  Asp Leu Pro 
    1295                 1300                 1305             


Tyr Pro  Pro Pro Gln Arg Glu  Ala Asn Ile Tyr Met  Val Pro Gln 
    1310                 1315                 1320             


Asn Ile  Lys Pro Ala Leu Gln  Arg Thr Ala Ile Glu  Ile Leu Ala 
    1325                 1330                 1335             


Trp Gly  Leu Arg Asn Met Lys  Ser Tyr Gln Leu Ala  Asn Ile Ser 
    1340                 1345                 1350             


Ser Pro  Ser Leu Val Val Glu  Cys Gly Gly Gln Thr  Val Gln Ser 
    1355                 1360                 1365             


Cys Val  Ile Arg Asn Leu Arg  Lys Asn Pro Asn Phe  Asp Ile Cys 
    1370                 1375                 1380             


Thr Leu  Phe Met Glu Val Met  Leu Pro Arg Glu Glu  Leu Tyr Cys 
    1385                 1390                 1395             


Pro Pro  Ile Thr Val Lys Val  Ile Asp Asn Arg Gln  Phe Gly Arg 
    1400                 1405                 1410             


Arg Pro  Val Val Gly Gln Cys  Thr Ile Arg Ser Leu  Glu Ser Phe 
    1415                 1420                 1425             


Leu Cys  Asp Pro Tyr Ser Ala  Glu Ser Pro Ser Pro  Gln Gly Gly 
    1430                 1435                 1440             


Pro Asp  Asp Val Ser Leu Leu  Ser Pro Gly Glu Asp  Val Leu Ile 
    1445                 1450                 1455             


Asp Ile  Asp Asp Lys Glu Pro  Leu Ile Pro Ile Gln  Glu Glu Glu 
    1460                 1465                 1470             


Phe Ile  Asp Trp Trp Ser Lys  Phe Phe Ala Ser Ile  Gly Glu Arg 
    1475                 1480                 1485             


Glu Lys  Cys Gly Ser Tyr Leu  Glu Lys Asp Phe Asp  Thr Leu Lys 
    1490                 1495                 1500             


Val Tyr  Asp Thr Gln Leu Glu  Asn Val Glu Ala Phe  Glu Gly Leu 
    1505                 1510                 1515             


Ser Asp  Phe Cys Asn Thr Phe  Lys Leu Tyr Arg Gly  Lys Thr Gln 
    1520                 1525                 1530             


Glu Glu  Thr Glu Asp Pro Ser  Val Ile Gly Glu Phe  Lys Gly Leu 
    1535                 1540                 1545             


Phe Lys  Ile Tyr Pro Leu Pro  Glu Asp Pro Ala Ile  Pro Met Pro 
    1550                 1555                 1560             


Pro Arg  Gln Phe His Gln Leu  Ala Ala Gln Gly Pro  Gln Glu Cys 
    1565                 1570                 1575             


Leu Val  Arg Ile Tyr Ile Val  Arg Ala Phe Gly Leu  Gln Pro Lys 
    1580                 1585                 1590             


Asp Pro  Asn Gly Lys Cys Asp  Pro Tyr Ile Lys Ile  Ser Ile Gly 
    1595                 1600                 1605             


Lys Lys  Ser Val Ser Asp Gln  Asp Asn Tyr Ile Pro  Cys Thr Leu 
    1610                 1615                 1620             


Glu Pro  Val Phe Gly Lys Met  Phe Glu Leu Thr Cys  Thr Leu Pro 
    1625                 1630                 1635             


Leu Glu  Lys Asp Leu Lys Ile  Thr Leu Tyr Asp Tyr  Asp Leu Leu 
    1640                 1645                 1650             


Ser Lys  Asp Glu Lys Ile Gly  Glu Thr Val Val Asp  Leu Glu Asn 
    1655                 1660                 1665             


Arg Leu  Leu Ser Lys Phe Gly  Ala Arg Cys Gly Leu  Pro Gln Thr 
    1670                 1675                 1680             


Tyr Cys  Val Ser Gly Pro Asn  Gln Trp Arg Asp Gln  Leu Arg Pro 
    1685                 1690                 1695             


Ser Gln  Leu Leu His Leu Phe  Cys Gln Gln His Arg  Val Lys Ala 
    1700                 1705                 1710             


Pro Val  Tyr Arg Thr Asp Arg  Val Met Phe Gln Asp  Lys Glu Tyr 
    1715                 1720                 1725             


Ser Ile  Glu Glu Ile Glu Ala  Gly Arg Ile Pro Asn  Pro His Leu 
    1730                 1735                 1740             


Gly Pro  Val Glu Glu Arg Leu  Ala Leu His Val Leu  Gln Gln Gln 
    1745                 1750                 1755             


Gly Leu  Val Pro Glu His Val  Glu Ser Arg Pro Leu  Tyr Ser Pro 
    1760                 1765                 1770             


Leu Gln  Pro Asp Ile Glu Gln  Gly Lys Leu Gln Met  Trp Val Asp 
    1775                 1780                 1785             


Leu Phe  Pro Lys Ala Leu Gly  Arg Pro Gly Pro Pro  Phe Asn Ile 
    1790                 1795                 1800             


Thr Pro  Arg Arg Ala Arg Arg  Phe Phe Leu Arg Cys  Ile Ile Trp 
    1805                 1810                 1815             


Asn Thr  Arg Asp Val Ile Leu  Asp Asp Leu Ser Leu  Thr Gly Glu 
    1820                 1825                 1830             


Lys Met  Ser Asp Ile Tyr Val  Lys Gly Trp Met Ile  Gly Phe Glu 
    1835                 1840                 1845             


Glu His  Lys Gln Lys Thr Asp  Val His Tyr Arg Ser  Leu Gly Gly 
    1850                 1855                 1860             


Glu Gly  Asn Phe Asn Trp Arg  Phe Ile Phe Pro Phe  Asp Tyr Leu 
    1865                 1870                 1875             


Pro Ala  Glu Gln Val Cys Thr  Ile Ala Lys Lys Asp  Ala Phe Trp 
    1880                 1885                 1890             


Arg Leu  Asp Lys Thr Glu Ser  Lys Ile Pro Ala Arg  Val Val Phe 
    1895                 1900                 1905             


Gln Ile  Trp Asp Asn Asp Lys  Phe Ser Phe Asp Asp  Phe Leu Gly 
    1910                 1915                 1920             


Ser Leu  Gln Leu Asp Leu Asn  Arg Met Pro Lys Pro  Ala Lys Thr 
    1925                 1930                 1935             


Ala Lys  Lys Cys Ser Leu Asp  Gln Leu Asp Asp Ala  Phe His Pro 
    1940                 1945                 1950             


Glu Trp  Phe Val Ser Leu Phe  Glu Gln Lys Thr Val  Lys Gly Trp 
    1955                 1960                 1965             


Trp Pro  Cys Val Ala Glu Glu  Gly Glu Lys Lys Ile  Leu Ala Gly 
    1970                 1975                 1980             


Lys Leu  Glu Met Thr Leu Glu  Ile Val Ala Glu Ser  Glu His Glu 
    1985                 1990                 1995             


Glu Arg  Pro Ala Gly Gln Gly  Arg Asp Glu Pro Asn  Met Asn Pro 
    2000                 2005                 2010             


Lys Leu  Glu Asp Pro Arg Arg  Pro Asp Thr Ser Phe  Leu Trp Phe 
    2015                 2020                 2025             


Thr Ser  Pro Tyr Lys Thr Met  Lys Phe Ile Leu Trp  Arg Arg Phe 
    2030                 2035                 2040             


Arg Trp  Ala Ile Ile Leu Phe  Ile Ile Leu Phe Ile  Leu Leu Leu 
    2045                 2050                 2055             


Phe Leu  Ala Ile Phe Ile Tyr  Ala Phe Pro Asn Tyr  Ala Ala Met 
    2060                 2065                 2070             


Lys Leu  Val Lys Pro Phe Ser  
    2075                 2080 


<210>  2843
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  2843

Met Ser Ile Met Asp His Ser Pro Thr Thr Gly Val Val Thr Val Ile 
1               5                   10                  15      


Val Ile Leu Ile Ala Ile Ala Ala Leu Gly Ala Leu Ile Leu Gly Cys 
            20                  25                  30          


Trp Cys Tyr Leu Arg Leu Gln Arg Ile Ser Gln Ser Glu Asp Glu Glu 
        35                  40                  45              


Ser Ile Val Gly Asp Gly Glu Thr Lys Glu Pro Phe Leu Leu Val Gln 
    50                  55                  60                  


Tyr Ser Ala Lys Gly Pro Cys Val Glu Arg Lys Ala Lys Leu Met Thr 
65                  70                  75                  80  


Pro Asn Gly Pro Glu Val His Gly 
                85              


<210>  2844
<211>  706
<212>  PRT
<213>  Homo sapiens

<400>  2844

Met Glu Met Phe Thr Phe Leu Leu Thr Cys Ile Phe Leu Pro Leu Leu 
1               5                   10                  15      


Arg Gly His Ser Leu Phe Thr Cys Glu Pro Ile Thr Val Pro Arg Cys 
            20                  25                  30          


Met Lys Met Ala Tyr Asn Met Thr Phe Phe Pro Asn Leu Met Gly His 
        35                  40                  45              


Tyr Asp Gln Ser Ile Ala Ala Val Glu Met Glu His Phe Leu Pro Leu 
    50                  55                  60                  


Ala Asn Leu Glu Cys Ser Pro Asn Ile Glu Thr Phe Leu Cys Lys Ala 
65                  70                  75                  80  


Phe Val Pro Thr Cys Ile Glu Gln Ile His Val Val Pro Pro Cys Arg 
                85                  90                  95      


Lys Leu Cys Glu Lys Val Tyr Ser Asp Cys Lys Lys Leu Ile Asp Thr 
            100                 105                 110         


Phe Gly Ile Arg Trp Pro Glu Glu Leu Glu Cys Asp Arg Leu Gln Tyr 
        115                 120                 125             


Cys Asp Glu Thr Val Pro Val Thr Phe Asp Pro His Thr Glu Phe Leu 
    130                 135                 140                 


Gly Pro Gln Lys Lys Thr Glu Gln Val Gln Arg Asp Ile Gly Phe Trp 
145                 150                 155                 160 


Cys Pro Arg His Leu Lys Thr Ser Gly Gly Gln Gly Tyr Lys Phe Leu 
                165                 170                 175     


Gly Ile Asp Gln Cys Ala Pro Pro Cys Pro Asn Met Tyr Phe Lys Ser 
            180                 185                 190         


Asp Glu Leu Glu Phe Ala Lys Ser Phe Ile Gly Thr Val Ser Ile Phe 
        195                 200                 205             


Cys Leu Cys Ala Thr Leu Phe Thr Phe Leu Thr Phe Leu Ile Asp Val 
    210                 215                 220                 


Arg Arg Phe Arg Tyr Pro Glu Arg Pro Ile Ile Tyr Tyr Ser Val Cys 
225                 230                 235                 240 


Tyr Ser Ile Val Ser Leu Met Tyr Phe Ile Gly Phe Leu Leu Gly Asp 
                245                 250                 255     


Ser Thr Ala Cys Asn Lys Ala Asp Glu Lys Leu Glu Leu Gly Asp Thr 
            260                 265                 270         


Val Val Leu Gly Ser Gln Asn Lys Ala Cys Thr Val Leu Phe Met Leu 
        275                 280                 285             


Leu Tyr Phe Phe Thr Met Ala Gly Thr Val Trp Trp Val Ile Leu Thr 
    290                 295                 300                 


Ile Thr Trp Phe Leu Ala Ala Gly Arg Lys Trp Ser Cys Glu Ala Ile 
305                 310                 315                 320 


Glu Gln Lys Ala Val Trp Phe His Ala Val Ala Trp Gly Thr Pro Gly 
                325                 330                 335     


Phe Leu Thr Val Met Leu Leu Ala Met Asn Lys Val Glu Gly Asp Asn 
            340                 345                 350         


Ile Ser Gly Val Cys Phe Val Gly Leu Tyr Asp Leu Asp Ala Ser Arg 
        355                 360                 365             


Tyr Phe Val Leu Leu Pro Leu Cys Leu Cys Val Phe Val Gly Leu Ser 
    370                 375                 380                 


Leu Leu Leu Ala Gly Ile Ile Ser Leu Asn His Val Arg Gln Val Ile 
385                 390                 395                 400 


Gln His Asp Gly Arg Asn Gln Glu Lys Leu Lys Lys Phe Met Ile Arg 
                405                 410                 415     


Ile Gly Val Phe Ser Gly Leu Tyr Leu Val Pro Leu Val Thr Leu Leu 
            420                 425                 430         


Gly Cys Tyr Val Tyr Glu Gln Val Asn Arg Ile Thr Trp Glu Ile Thr 
        435                 440                 445             


Trp Val Ser Asp His Cys Arg Gln Tyr His Ile Pro Cys Pro Tyr Gln 
    450                 455                 460                 


Ala Lys Ala Lys Ala Arg Pro Glu Leu Ala Leu Phe Met Ile Lys Tyr 
465                 470                 475                 480 


Leu Met Thr Leu Ile Val Gly Ile Ser Ala Val Phe Trp Val Gly Ser 
                485                 490                 495     


Lys Lys Thr Cys Thr Glu Trp Ala Gly Phe Phe Lys Arg Asn Arg Lys 
            500                 505                 510         


Arg Asp Pro Ile Ser Glu Ser Arg Arg Val Leu Gln Glu Ser Cys Glu 
        515                 520                 525             


Phe Phe Leu Lys His Asn Ser Lys Val Lys His Lys Lys Lys His Tyr 
    530                 535                 540                 


Lys Pro Ser Ser His Lys Leu Lys Val Ile Ser Lys Ser Met Gly Thr 
545                 550                 555                 560 


Ser Thr Gly Ala Thr Ala Asn His Gly Thr Ser Ala Val Ala Ile Thr 
                565                 570                 575     


Ser His Asp Tyr Leu Gly Gln Glu Thr Leu Thr Glu Ile Gln Thr Ser 
            580                 585                 590         


Pro Glu Thr Ser Met Arg Glu Val Lys Ala Asp Gly Ala Ser Thr Pro 
        595                 600                 605             


Arg Leu Arg Glu Gln Asp Cys Gly Glu Pro Ala Ser Pro Ala Ala Ser 
    610                 615                 620                 


Ile Ser Arg Leu Ser Gly Glu Gln Val Asp Gly Lys Gly Gln Ala Gly 
625                 630                 635                 640 


Ser Val Ser Glu Ser Ala Arg Ser Glu Gly Arg Ile Ser Pro Lys Ser 
                645                 650                 655     


Asp Ile Thr Asp Thr Gly Leu Ala Gln Ser Asn Asn Leu Gln Val Pro 
            660                 665                 670         


Ser Ser Ser Glu Pro Ser Ser Leu Lys Gly Ser Thr Ser Leu Leu Val 
        675                 680                 685             


His Pro Val Ser Gly Val Arg Lys Glu Gln Gly Gly Gly Cys His Ser 
    690                 695                 700                 


Asp Thr 
705     


<210>  2845
<211>  574
<212>  PRT
<213>  Homo sapiens

<400>  2845

Met Arg Asp Pro Gly Ala Ala Ala Pro Leu Ser Ser Leu Gly Leu Cys 
1               5                   10                  15      


Ala Leu Val Leu Ala Leu Leu Gly Ala Leu Ser Ala Gly Ala Gly Ala 
            20                  25                  30          


Gln Pro Tyr His Gly Glu Lys Gly Ile Ser Val Pro Asp His Gly Phe 
        35                  40                  45              


Cys Gln Pro Ile Ser Ile Pro Leu Cys Thr Asp Ile Ala Tyr Asn Gln 
    50                  55                  60                  


Thr Ile Leu Pro Asn Leu Leu Gly His Thr Asn Gln Glu Asp Ala Gly 
65                  70                  75                  80  


Leu Glu Val His Gln Phe Tyr Pro Leu Val Lys Val Gln Cys Ser Pro 
                85                  90                  95      


Glu Leu Arg Phe Phe Leu Cys Ser Met Tyr Ala Pro Val Cys Thr Val 
            100                 105                 110         


Leu Asp Gln Ala Ile Pro Pro Cys Arg Ser Leu Cys Glu Arg Ala Arg 
        115                 120                 125             


Gln Gly Cys Glu Ala Leu Met Asn Lys Phe Gly Phe Gln Trp Pro Glu 
    130                 135                 140                 


Arg Leu Arg Cys Glu Asn Phe Pro Val His Gly Ala Gly Glu Ile Cys 
145                 150                 155                 160 


Val Gly Gln Asn Thr Ser Asp Gly Ser Gly Gly Pro Gly Gly Gly Pro 
                165                 170                 175     


Thr Ala Tyr Pro Thr Ala Pro Tyr Leu Pro Asp Leu Pro Phe Thr Ala 
            180                 185                 190         


Leu Pro Pro Gly Ala Ser Asp Gly Arg Gly Arg Pro Ala Phe Pro Phe 
        195                 200                 205             


Ser Cys Pro Arg Gln Leu Lys Val Pro Pro Tyr Leu Gly Tyr Arg Phe 
    210                 215                 220                 


Leu Gly Glu Arg Asp Cys Gly Ala Pro Cys Glu Pro Gly Arg Ala Asn 
225                 230                 235                 240 


Gly Leu Met Tyr Phe Lys Glu Glu Glu Arg Arg Phe Ala Arg Leu Trp 
                245                 250                 255     


Val Gly Val Trp Ser Val Leu Cys Cys Ala Ser Thr Leu Phe Thr Val 
            260                 265                 270         


Leu Thr Tyr Leu Val Asp Met Arg Arg Phe Ser Tyr Pro Glu Arg Pro 
        275                 280                 285             


Ile Ile Phe Leu Ser Gly Cys Tyr Phe Met Val Ala Val Ala His Val 
    290                 295                 300                 


Ala Gly Phe Leu Leu Glu Asp Arg Ala Val Cys Val Glu Arg Phe Ser 
305                 310                 315                 320 


Asp Asp Gly Tyr Arg Thr Val Ala Gln Gly Thr Lys Lys Glu Gly Cys 
                325                 330                 335     


Thr Ile Leu Phe Met Val Leu Tyr Phe Phe Gly Met Ala Ser Ser Ile 
            340                 345                 350         


Trp Trp Val Ile Leu Ser Leu Thr Trp Phe Leu Ala Ala Gly Met Lys 
        355                 360                 365             


Trp Gly His Glu Ala Ile Glu Ala Asn Ser Gln Tyr Phe His Leu Ala 
    370                 375                 380                 


Ala Trp Ala Val Pro Ala Val Lys Thr Ile Thr Ile Leu Ala Met Gly 
385                 390                 395                 400 


Gln Val Asp Gly Asp Leu Leu Ser Gly Val Cys Tyr Val Gly Leu Ser 
                405                 410                 415     


Ser Val Asp Ala Leu Arg Gly Phe Val Leu Ala Pro Leu Phe Val Tyr 
            420                 425                 430         


Leu Phe Ile Gly Thr Ser Phe Leu Leu Ala Gly Phe Val Ser Leu Phe 
        435                 440                 445             


Arg Ile Arg Thr Ile Met Lys His Asp Gly Thr Lys Thr Glu Lys Leu 
    450                 455                 460                 


Glu Lys Leu Met Val Arg Ile Gly Val Phe Ser Val Leu Tyr Thr Val 
465                 470                 475                 480 


Pro Ala Thr Ile Val Leu Ala Cys Tyr Phe Tyr Glu Gln Ala Phe Arg 
                485                 490                 495     


Glu His Trp Glu Arg Thr Trp Leu Leu Gln Thr Cys Lys Ser Tyr Ala 
            500                 505                 510         


Val Pro Cys Pro Pro Gly His Phe Pro Pro Met Ser Pro Asp Phe Thr 
        515                 520                 525             


Val Phe Met Ile Lys Tyr Leu Met Thr Met Ile Val Gly Ile Thr Thr 
    530                 535                 540                 


Gly Phe Trp Ile Trp Ser Gly Lys Thr Leu Gln Ser Trp Arg Arg Phe 
545                 550                 555                 560 


Tyr His Arg Leu Ser His Ser Ser Lys Gly Glu Thr Ala Val 
                565                 570                 


<210>  2846
<211>  591
<212>  PRT
<213>  Homo sapiens

<400>  2846

Met Ala Val Ala Pro Leu Arg Gly Ala Leu Leu Leu Trp Gln Leu Leu 
1               5                   10                  15      


Ala Ala Gly Gly Ala Ala Leu Glu Ile Gly Arg Phe Asp Pro Glu Arg 
            20                  25                  30          


Gly Arg Gly Ala Ala Pro Cys Gln Ala Val Glu Ile Pro Met Cys Arg 
        35                  40                  45              


Gly Ile Gly Tyr Asn Leu Thr Arg Met Pro Asn Leu Leu Gly His Thr 
    50                  55                  60                  


Ser Gln Gly Glu Ala Ala Ala Glu Leu Ala Glu Phe Ala Pro Leu Val 
65                  70                  75                  80  


Gln Tyr Gly Cys His Ser His Leu Arg Phe Phe Leu Cys Ser Leu Tyr 
                85                  90                  95      


Ala Pro Met Cys Thr Asp Gln Val Ser Thr Pro Ile Pro Ala Cys Arg 
            100                 105                 110         


Pro Met Cys Glu Gln Ala Arg Leu Arg Cys Ala Pro Ile Met Glu Gln 
        115                 120                 125             


Phe Asn Phe Gly Trp Pro Asp Ser Leu Asp Cys Ala Arg Leu Pro Thr 
    130                 135                 140                 


Arg Asn Asp Pro His Ala Leu Cys Met Glu Ala Pro Glu Asn Ala Thr 
145                 150                 155                 160 


Ala Gly Pro Ala Glu Pro His Lys Gly Leu Gly Met Leu Pro Val Ala 
                165                 170                 175     


Pro Arg Pro Ala Arg Pro Pro Gly Asp Leu Gly Pro Gly Ala Gly Gly 
            180                 185                 190         


Ser Gly Thr Cys Glu Asn Pro Glu Lys Phe Gln Tyr Val Glu Lys Ser 
        195                 200                 205             


Arg Ser Cys Ala Pro Arg Cys Gly Pro Gly Val Glu Val Phe Trp Ser 
    210                 215                 220                 


Arg Arg Asp Lys Asp Phe Ala Leu Val Trp Met Ala Val Trp Ser Ala 
225                 230                 235                 240 


Leu Cys Phe Phe Ser Thr Ala Phe Thr Val Leu Thr Phe Leu Leu Glu 
                245                 250                 255     


Pro His Arg Phe Gln Tyr Pro Glu Arg Pro Ile Ile Phe Leu Ser Met 
            260                 265                 270         


Cys Tyr Asn Val Tyr Ser Leu Ala Phe Leu Ile Arg Ala Val Ala Gly 
        275                 280                 285             


Ala Gln Ser Val Ala Cys Asp Gln Glu Ala Gly Ala Leu Tyr Val Ile 
    290                 295                 300                 


Gln Glu Gly Leu Glu Asn Thr Gly Cys Thr Leu Val Phe Leu Leu Leu 
305                 310                 315                 320 


Tyr Tyr Phe Gly Met Ala Ser Ser Leu Trp Trp Val Val Leu Thr Leu 
                325                 330                 335     


Thr Trp Phe Leu Ala Ala Gly Lys Lys Trp Gly His Glu Ala Ile Glu 
            340                 345                 350         


Ala His Gly Ser Tyr Phe His Met Ala Ala Trp Gly Leu Pro Ala Leu 
        355                 360                 365             


Lys Thr Ile Val Ile Leu Thr Leu Arg Lys Val Ala Gly Asp Glu Leu 
    370                 375                 380                 


Thr Gly Leu Cys Tyr Val Ala Ser Thr Asp Ala Ala Ala Leu Thr Gly 
385                 390                 395                 400 


Phe Val Leu Val Pro Leu Ser Gly Tyr Leu Val Leu Gly Ser Ser Phe 
                405                 410                 415     


Leu Leu Thr Gly Phe Val Ala Leu Phe His Ile Arg Lys Ile Met Lys 
            420                 425                 430         


Thr Gly Gly Thr Asn Thr Glu Lys Leu Glu Lys Leu Met Val Lys Ile 
        435                 440                 445             


Gly Val Phe Ser Ile Leu Tyr Thr Val Pro Ala Thr Cys Val Ile Val 
    450                 455                 460                 


Cys Tyr Val Tyr Glu Arg Leu Asn Met Asp Phe Trp Arg Leu Arg Ala 
465                 470                 475                 480 


Thr Glu Gln Pro Cys Ala Ala Ala Ala Gly Pro Gly Gly Arg Arg Asp 
                485                 490                 495     


Cys Ser Leu Pro Gly Gly Ser Val Pro Thr Val Ala Val Phe Met Leu 
            500                 505                 510         


Lys Ile Phe Met Ser Leu Val Val Gly Ile Thr Ser Gly Val Trp Val 
        515                 520                 525             


Trp Ser Ser Lys Thr Phe Gln Thr Trp Gln Ser Leu Cys Tyr Arg Lys 
    530                 535                 540                 


Ile Ala Ala Gly Arg Ala Arg Ala Lys Ala Cys Arg Ala Pro Gly Ser 
545                 550                 555                 560 


Tyr Gly Arg Gly Thr His Cys His Tyr Lys Ala Pro Thr Val Val Leu 
                565                 570                 575     


His Met Thr Lys Thr Asp Pro Ser Leu Glu Asn Pro Thr His Leu 
            580                 585                 590     


<210>  2847
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  2847

Met Glu Gly Lys Asn Leu Thr Ser Ile Ser Glu Cys Phe Leu Leu Gly 
1               5                   10                  15      


Phe Ser Glu Gln Leu Glu Glu Gln Lys Pro Leu Phe Gly Ser Phe Leu 
            20                  25                  30          


Phe Met Tyr Leu Val Thr Val Ala Gly Asn Leu Leu Ile Ile Leu Val 
        35                  40                  45              


Ile Ile Thr Asp Thr Gln Leu His Thr Pro Met Tyr Phe Phe Leu Ala 
    50                  55                  60                  


Asn Leu Ser Leu Ala Asp Ala Cys Phe Val Ser Thr Thr Val Pro Lys 
65                  70                  75                  80  


Met Leu Ala Asn Ile Gln Ile Gln Ser Gln Ala Ile Ser Tyr Ser Gly 
                85                  90                  95      


Cys Leu Leu Gln Leu Tyr Phe Phe Met Leu Phe Val Met Leu Glu Ala 
            100                 105                 110         


Phe Leu Leu Ala Val Met Ala Tyr Asp Cys Tyr Val Ala Ile Cys His 
        115                 120                 125             


Pro Leu His Tyr Ile Leu Ile Met Ser Pro Gly Leu Cys Ile Phe Leu 
    130                 135                 140                 


Val Ser Ala Ser Trp Ile Met Asn Ala Leu His Ser Leu Leu His Thr 
145                 150                 155                 160 


Leu Leu Met Asn Ser Leu Ser Phe Cys Ala Asn His Glu Ile Pro His 
                165                 170                 175     


Phe Phe Cys Asp Ile Asn Pro Leu Leu Ser Leu Ser Cys Thr Asp Pro 
            180                 185                 190         


Phe Thr Asn Glu Leu Val Ile Phe Ile Thr Gly Gly Leu Thr Gly Leu 
        195                 200                 205             


Ile Cys Val Leu Cys Leu Ile Ile Ser Tyr Thr Asn Val Phe Ser Thr 
    210                 215                 220                 


Ile Leu Lys Ile Pro Ser Ala Gln Gly Lys Arg Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Ser Ser His Leu Ser Val Val Ser Leu Phe Phe Gly Thr Ser Phe 
                245                 250                 255     


Cys Val Asp Phe Ser Ser Pro Ser Thr His Ser Ala Gln Lys Asp Thr 
            260                 265                 270         


Val Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Gln Glu Ile Lys Ser Ser Leu Arg Lys Leu 
    290                 295                 300                 


Ile Trp Val Arg Lys Ile His Ser Pro 
305                 310             


<210>  2848
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  2848

Met Gly Pro Leu Pro Val Cys Leu Pro Ile Met Leu Leu Leu Leu Leu 
1               5                   10                  15      


Pro Ser Leu Leu Leu Leu Leu Leu Leu Pro Gly Pro Gly Ser Gly Glu 
            20                  25                  30          


Ala Ser Arg Ile Leu Arg Val His Arg Arg Gly Ile Leu Glu Leu Ala 
        35                  40                  45              


Gly Thr Val Gly Cys Val Gly Pro Arg Thr Pro Ile Ala Tyr Met Lys 
    50                  55                  60                  


Tyr Gly Cys Phe Cys Gly Leu Gly Gly His Gly Gln Pro Arg Asp Ala 
65                  70                  75                  80  


Ile Asp Trp Cys Cys His Gly His Asp Cys Cys Tyr Thr Arg Ala Glu 
                85                  90                  95      


Glu Ala Gly Cys Ser Pro Lys Thr Glu Arg Tyr Ser Trp Gln Cys Val 
            100                 105                 110         


Asn Gln Ser Val Leu Cys Gly Pro Ala Glu Asn Lys Cys Gln Glu Leu 
        115                 120                 125             


Leu Cys Lys Cys Asp Gln Glu Ile Ala Asn Cys Leu Ala Gln Thr Glu 
    130                 135                 140                 


Tyr Asn Leu Lys Tyr Leu Phe Tyr Pro Gln Phe Leu Cys Glu Pro Asp 
145                 150                 155                 160 


Ser Pro Lys Cys Asp 
                165 


<210>  2849
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  2849

Met Ser Tyr Thr Pro Gly Val Gly Gly Asp Pro Ala Gln Leu Ala Gln 
1               5                   10                  15      


Arg Ile Ser Ser Asn Ile Gln Lys Ile Thr Gln Cys Ser Val Glu Ile 
            20                  25                  30          


Gln Arg Thr Leu Asn Gln Leu Gly Thr Pro Gln Asp Ser Pro Glu Leu 
        35                  40                  45              


Arg Gln Gln Leu Gln Gln Lys Gln Gln Tyr Thr Asn Gln Leu Ala Lys 
    50                  55                  60                  


Glu Thr Asp Lys Tyr Ile Lys Glu Phe Gly Ser Leu Pro Thr Thr Pro 
65                  70                  75                  80  


Ser Glu Gln Arg Gln Arg Lys Ile Gln Lys Asp Arg Leu Val Ala Glu 
                85                  90                  95      


Phe Thr Thr Ser Leu Thr Asn Phe Gln Lys Val Gln Arg Gln Ala Ala 
            100                 105                 110         


Glu Arg Glu Lys Glu Phe Val Ala Arg Val Arg Ala Ser Ser Arg Val 
        115                 120                 125             


Ser Gly Ser Phe Pro Glu Asp Ser Ser Lys Glu Arg Asn Leu Val Ser 
    130                 135                 140                 


Trp Glu Ser Gln Thr Gln Pro Gln Val Gln Val Gln Asp Glu Glu Ile 
145                 150                 155                 160 


Thr Glu Asp Asp Leu Arg Leu Ile His Glu Arg Glu Ser Ser Ile Arg 
                165                 170                 175     


Gln Leu Glu Ala Asp Ile Met Asp Ile Asn Glu Ile Phe Lys Asp Leu 
            180                 185                 190         


Gly Met Met Ile His Glu Gln Gly Asp Val Ile Asp Ser Ile Glu Ala 
        195                 200                 205             


Asn Val Glu Asn Ala Glu Val His Val Gln Gln Ala Asn Gln Gln Leu 
    210                 215                 220                 


Ser Arg Ala Ala Asp Tyr Gln Arg Lys Ser Arg Lys Thr Leu Cys Ile 
225                 230                 235                 240 


Ile Ile Leu Ile Leu Val Ile Gly Val Ala Ile Ile Ser Leu Ile Ile 
                245                 250                 255     


Trp Gly Leu Asn His 
            260     


<210>  2850
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  2850

Met Ala Ser Ala Ser Gly Ala Met Ala Lys His Glu Gln Ile Leu Val 
1               5                   10                  15      


Leu Asp Pro Pro Thr Asp Leu Lys Phe Lys Gly Pro Phe Thr Asp Val 
            20                  25                  30          


Val Thr Thr Asn Leu Lys Leu Arg Asn Pro Ser Asp Arg Lys Val Cys 
        35                  40                  45              


Phe Lys Val Lys Thr Thr Ala Pro Arg Arg Tyr Cys Val Arg Pro Asn 
    50                  55                  60                  


Ser Gly Ile Ile Asp Pro Gly Ser Thr Val Thr Val Ser Val Met Leu 
65                  70                  75                  80  


Gln Pro Phe Asp Tyr Asp Pro Asn Glu Lys Ser Lys His Lys Phe Met 
                85                  90                  95      


Val Gln Thr Ile Phe Ala Pro Pro Asn Thr Ser Asp Met Glu Ala Val 
            100                 105                 110         


Trp Lys Glu Ala Lys Pro Asp Glu Leu Met Asp Ser Lys Leu Arg Cys 
        115                 120                 125             


Val Phe Glu Met Pro Asn Glu Asn Asp Lys Leu Gly Ile Thr Pro Pro 
    130                 135                 140                 


Gly Asn Ala Pro Thr Val Thr Ser Met Ser Ser Ile Asn Asn Thr Val 
145                 150                 155                 160 


Ala Thr Pro Ala Ser Tyr His Thr Lys Asp Asp Pro Arg Gly Leu Ser 
                165                 170                 175     


Val Leu Lys Gln Glu Lys Gln Lys Asn Asp Met Glu Pro Ser Lys Ala 
            180                 185                 190         


Val Pro Leu Asn Ala Ser Lys Gln Asp Gly Pro Met Pro Lys Pro His 
        195                 200                 205             


Ser Val Ser Leu Asn Asp Thr Glu Thr Arg Lys Leu Met Glu Glu Cys 
    210                 215                 220                 


Lys Arg Leu Gln Gly Glu Met Met Lys Leu Ser Glu Glu Asn Arg His 
225                 230                 235                 240 


Leu Arg Asp Glu Gly Leu Arg Leu Arg Lys Val Ala His Ser Asp Lys 
                245                 250                 255     


Pro Gly Ser Thr Ser Thr Ala Ser Phe Arg Asp Asn Val Thr Ser Pro 
            260                 265                 270         


Leu Pro Ser Leu Leu Val Val Ile Ala Ala Ile Phe Ile Gly Phe Phe 
        275                 280                 285             


Leu Gly Lys Phe Ile Leu 
    290                 


<210>  2851
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  2851

Met Glu Pro Gly Gly Ala Arg Leu Arg Leu Gln Arg Thr Glu Gly Leu 
1               5                   10                  15      


Gly Gly Glu Arg Glu Arg Gln Pro Cys Gly Asp Gly Asn Thr Glu Thr 
            20                  25                  30          


His Arg Ala Pro Asp Leu Val Gln Trp Thr Arg His Met Glu Ala Val 
        35                  40                  45              


Lys Ala Gln Leu Leu Glu Gln Ala Gln Gly Gln Leu Arg Glu Leu Leu 
    50                  55                  60                  


Asp Arg Ala Met Arg Glu Ala Ile Gln Ser Tyr Pro Ser Gln Asp Lys 
65                  70                  75                  80  


Pro Leu Pro Pro Pro Pro Pro Gly Ser Leu Ser Arg Thr Gln Glu Pro 
                85                  90                  95      


Ser Leu Gly Lys Gln Lys Val Phe Ile Ile Arg Lys Ser Leu Leu Asp 
            100                 105                 110         


Glu Leu Met Glu Val Gln His Phe Arg Thr Ile Tyr His Met Phe Ile 
        115                 120                 125             


Ala Gly Leu Cys Val Phe Ile Ile Ser Thr Leu Ala Ile Asp Phe Ile 
    130                 135                 140                 


Asp Glu Gly Arg Leu Leu Leu Glu Phe Asp Leu Leu Ile Phe Ser Phe 
145                 150                 155                 160 


Gly Gln Leu Pro Leu Ala Leu Val Thr Trp Val Pro Met Phe Leu Ser 
                165                 170                 175     


Thr Leu Leu Ala Pro Tyr Gln Ala Leu Arg Leu Trp Ala Arg Gly Thr 
            180                 185                 190         


Trp Thr Gln Ala Thr Gly Leu Gly Cys Ala Leu Leu Ala Ala His Ala 
        195                 200                 205             


Val Val Leu Cys Ala Leu Pro Val His Val Ala Val Glu His Gln Leu 
    210                 215                 220                 


Pro Pro Ala Ser Arg Cys Val Leu Val Phe Glu Gln Val Arg Phe Leu 
225                 230                 235                 240 


Met Lys Ser Tyr Ser Phe Leu Arg Glu Ala Val Pro Gly Thr Leu Arg 
                245                 250                 255     


Ala Arg Arg Gly Glu Gly Ile Gln Ala Pro Ser Phe Ser Ser Tyr Leu 
            260                 265                 270         


Tyr Phe Leu Phe Cys Pro Thr Leu Ile Tyr Arg Glu Thr Tyr Pro Arg 
        275                 280                 285             


Thr Pro Tyr Val Arg Trp Asn Tyr Val Ala Lys Asn Phe Ala Gln Ala 
    290                 295                 300                 


Leu Gly Cys Val Leu Tyr Ala Cys Phe Ile Leu Gly Arg Leu Cys Val 
305                 310                 315                 320 


Pro Val Phe Ala Asn Met Ser Arg Glu Pro Phe Ser Thr Arg Ala Leu 
                325                 330                 335     


Val Leu Ser Ile Leu His Ala Thr Leu Pro Gly Ile Phe Met Leu Leu 
            340                 345                 350         


Leu Ile Phe Phe Ala Phe Leu His Cys Trp Leu Asn Ala Phe Ala Glu 
        355                 360                 365             


Met Leu Arg Phe Gly Asp Arg Met Phe Tyr Arg Asp Trp Trp Asn Ser 
    370                 375                 380                 


Thr Ser Phe Ser Asn Tyr Tyr Arg Thr Trp Asn Val Val Val His Asp 
385                 390                 395                 400 


Trp Leu Tyr Ser Tyr Val Tyr Gln Asp Gly Leu Arg Leu Leu Gly Ala 
                405                 410                 415     


Arg Ala Arg Gly Val Ala Met Leu Gly Val Phe Leu Val Ser Ala Val 
            420                 425                 430         


Ala His Glu Tyr Ile Phe Cys Phe Val Leu Gly Phe Phe Tyr Pro Val 
        435                 440                 445             


Met Leu Ile Leu Phe Leu Val Ile Gly Gly Met Leu Asn Phe Met Met 
    450                 455                 460                 


His Asp Gln Arg Thr Gly Pro Ala Trp Asn Val Leu Met Trp Thr Met 
465                 470                 475                 480 


Leu Phe Leu Gly Gln Gly Ile Gln Val Ser Leu Tyr Cys Gln Glu Trp 
                485                 490                 495     


Tyr Ala Arg Arg His Cys Pro Leu Pro Gln Ala Thr Phe Trp Gly Leu 
            500                 505                 510         


Val Thr Pro Arg Ser Trp Ser Cys His Thr 
        515                 520         


<210>  2852
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  2852

Met Arg Leu Ser Val Arg Arg Val Leu Leu Ala Ala Gly Cys Ala Leu 
1               5                   10                  15      


Val Leu Val Leu Ala Val Gln Leu Gly Gln Gln Val Leu Glu Cys Arg 
            20                  25                  30          


Ala Val Leu Ala Gly Leu Arg Ser Pro Arg Gly Ala Met Arg Pro Glu 
        35                  40                  45              


Gln Glu Glu Leu Val Met Val Gly Thr Asn His Val Glu Tyr Arg Tyr 
    50                  55                  60                  


Gly Lys Ala Met Pro Leu Ile Phe Val Gly Gly Val Pro Arg Ser Gly 
65                  70                  75                  80  


Thr Thr Leu Met Arg Ala Met Leu Asp Ala His Pro Glu Val Arg Cys 
                85                  90                  95      


Gly Glu Glu Thr Arg Ile Ile Pro Arg Val Leu Ala Met Arg Gln Ala 
            100                 105                 110         


Trp Ser Lys Ser Gly Arg Glu Lys Leu Arg Leu Asp Glu Ala Gly Val 
        115                 120                 125             


Thr Asp Glu Val Leu Asp Ala Ala Met Gln Ala Phe Ile Leu Glu Val 
    130                 135                 140                 


Ile Ala Lys His Gly Glu Pro Ala Arg Val Leu Cys Asn Lys Asp Pro 
145                 150                 155                 160 


Phe Thr Leu Lys Ser Ser Val Tyr Leu Ser Arg Leu Phe Pro Asn Ser 
                165                 170                 175     


Lys Phe Leu Leu Met Val Arg Asp Gly Arg Ala Ser Val His Ser Met 
            180                 185                 190         


Ile Thr Arg Lys Val Thr Ile Ala Gly Phe Asp Leu Ser Ser Tyr Arg 
        195                 200                 205             


Asp Cys Leu Thr Lys Trp Asn Lys Ala Ile Glu Val Met Tyr Ala Gln 
    210                 215                 220                 


Cys Met Glu Val Gly Lys Glu Lys Cys Leu Pro Val Tyr Tyr Glu Gln 
225                 230                 235                 240 


Leu Val Leu His Pro Arg Arg Ser Leu Lys Leu Ile Leu Asp Phe Leu 
                245                 250                 255     


Gly Ile Ala Trp Ser Asp Ala Val Leu His His Glu Asp Leu Ile Gly 
            260                 265                 270         


Lys Pro Gly Gly Val Ser Leu Ser Lys Ile Glu Arg Ser Thr Asp Gln 
        275                 280                 285             


Val Ile Lys Pro Val Asn Leu Glu Ala Leu Ser Lys Trp Thr Gly His 
    290                 295                 300                 


Ile Pro Gly Asp Val Val Arg Asp Met Ala Gln Ile Ala Pro Met Leu 
305                 310                 315                 320 


Ala Gln Leu Gly Tyr Asp Pro Tyr Ala Asn Pro Pro Asn Tyr Gly Asn 
                325                 330                 335     


Pro Asp Pro Phe Val Ile Asn Asn Thr Gln Arg Val Leu Lys Gly Asp 
            340                 345                 350         


Tyr Lys Thr Pro Ala Asn Leu Lys Gly Tyr Phe Gln Val Asn Gln Asn 
        355                 360                 365             


Ser Thr Ser Ser His Leu Gly Ser Ser 
    370                 375         


<210>  2853
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  2853

Met Val Gly Lys Leu Lys Gln Asn Leu Leu Leu Ala Cys Leu Val Ile 
1               5                   10                  15      


Ser Ser Val Thr Val Phe Tyr Leu Gly Gln His Ala Met Glu Cys His 
            20                  25                  30          


His Arg Ile Glu Glu Arg Ser Gln Pro Val Lys Leu Glu Ser Thr Arg 
        35                  40                  45              


Thr Thr Val Arg Thr Gly Leu Asp Leu Lys Ala Asn Lys Thr Phe Ala 
    50                  55                  60                  


Tyr His Lys Asp Met Pro Leu Ile Phe Ile Gly Gly Val Pro Arg Ser 
65                  70                  75                  80  


Gly Thr Thr Leu Met Arg Ala Met Leu Asp Ala His Pro Asp Ile Arg 
                85                  90                  95      


Cys Gly Glu Glu Thr Arg Val Ile Pro Arg Ile Leu Ala Leu Lys Gln 
            100                 105                 110         


Met Trp Ser Arg Ser Ser Lys Glu Lys Ile Arg Leu Asp Glu Ala Gly 
        115                 120                 125             


Val Thr Asp Glu Val Leu Asp Ser Ala Met Gln Ala Phe Leu Leu Glu 
    130                 135                 140                 


Ile Ile Val Lys His Gly Glu Pro Ala Pro Tyr Leu Cys Asn Lys Asp 
145                 150                 155                 160 


Pro Phe Ala Leu Lys Ser Leu Thr Tyr Leu Ser Arg Leu Phe Pro Asn 
                165                 170                 175     


Ala Lys Phe Leu Leu Met Val Arg Asp Gly Arg Ala Ser Val His Ser 
            180                 185                 190         


Met Ile Ser Arg Lys Val Thr Ile Ala Gly Phe Asp Leu Asn Ser Tyr 
        195                 200                 205             


Arg Asp Cys Leu Thr Lys Trp Asn Arg Ala Ile Glu Thr Met Tyr Asn 
    210                 215                 220                 


Gln Cys Met Glu Val Gly Tyr Lys Lys Cys Met Leu Val His Tyr Glu 
225                 230                 235                 240 


Gln Leu Val Leu His Pro Glu Arg Trp Met Arg Thr Leu Leu Lys Phe 
                245                 250                 255     


Leu Gln Ile Pro Trp Asn His Ser Val Leu His His Glu Glu Met Ile 
            260                 265                 270         


Gly Lys Ala Gly Gly Val Ser Leu Ser Lys Val Glu Arg Ser Thr Asp 
        275                 280                 285             


Gln Val Ile Lys Pro Val Asn Val Gly Ala Leu Ser Lys Trp Val Gly 
    290                 295                 300                 


Lys Ile Pro Pro Asp Val Leu Gln Asp Met Ala Val Ile Ala Pro Met 
305                 310                 315                 320 


Leu Ala Lys Leu Gly Tyr Asp Pro Tyr Ala Asn Pro Pro Asn Tyr Gly 
                325                 330                 335     


Lys Pro Asp Pro Lys Ile Ile Glu Asn Thr Arg Arg Val Tyr Lys Gly 
            340                 345                 350         


Glu Phe Gln Leu Pro Asp Phe Leu Lys Glu Lys Pro Gln Thr Glu Gln 
        355                 360                 365             


Val Glu 
    370 


<210>  2854
<211>  368
<212>  PRT
<213>  Homo sapiens

<400>  2854

Met Ala Asp Ala Gln Asn Ile Ser Leu Asp Ser Pro Gly Ser Val Gly 
1               5                   10                  15      


Ala Val Ala Val Pro Val Val Phe Ala Leu Ile Phe Leu Leu Gly Thr 
            20                  25                  30          


Val Gly Asn Gly Leu Val Leu Ala Val Leu Leu Gln Pro Gly Pro Ser 
        35                  40                  45              


Ala Trp Gln Glu Pro Gly Ser Thr Thr Asp Leu Phe Ile Leu Asn Leu 
    50                  55                  60                  


Ala Val Ala Asp Leu Cys Phe Ile Leu Cys Cys Val Pro Phe Gln Ala 
65                  70                  75                  80  


Thr Ile Tyr Thr Leu Asp Ala Trp Leu Phe Gly Ala Leu Val Cys Lys 
                85                  90                  95      


Ala Val His Leu Leu Ile Tyr Leu Thr Met Tyr Ala Ser Ser Phe Thr 
            100                 105                 110         


Leu Ala Ala Val Ser Val Asp Arg Tyr Leu Ala Val Arg His Pro Leu 
        115                 120                 125             


Arg Ser Arg Ala Leu Arg Thr Pro Arg Asn Ala Arg Ala Ala Val Gly 
    130                 135                 140                 


Leu Val Trp Leu Leu Ala Ala Leu Phe Ser Ala Pro Tyr Leu Ser Tyr 
145                 150                 155                 160 


Tyr Gly Thr Val Arg Tyr Gly Ala Leu Glu Leu Cys Val Pro Ala Trp 
                165                 170                 175     


Glu Asp Ala Arg Arg Arg Ala Leu Asp Val Ala Thr Phe Ala Ala Gly 
            180                 185                 190         


Tyr Leu Leu Pro Val Ala Val Val Ser Leu Ala Tyr Gly Arg Thr Leu 
        195                 200                 205             


Arg Phe Leu Trp Ala Ala Val Gly Pro Ala Gly Ala Ala Ala Ala Glu 
    210                 215                 220                 


Ala Arg Arg Arg Ala Thr Gly Arg Ala Gly Arg Ala Met Leu Ala Val 
225                 230                 235                 240 


Ala Ala Leu Tyr Ala Leu Cys Trp Gly Pro His His Ala Leu Ile Leu 
                245                 250                 255     


Cys Phe Trp Tyr Gly Arg Phe Ala Phe Ser Pro Ala Thr Tyr Ala Cys 
            260                 265                 270         


Arg Leu Ala Ser His Cys Leu Ala Tyr Ala Asn Ser Cys Leu Asn Pro 
        275                 280                 285             


Leu Val Tyr Ala Leu Ala Ser Arg His Phe Arg Ala Arg Phe Arg Arg 
    290                 295                 300                 


Leu Trp Pro Cys Gly Arg Arg Arg Arg His Arg Ala Arg Arg Ala Leu 
305                 310                 315                 320 


Arg Arg Val Arg Pro Ala Ser Ser Gly Pro Pro Gly Cys Pro Gly Asp 
                325                 330                 335     


Ala Arg Pro Ser Gly Arg Leu Leu Ala Gly Gly Gly Gln Gly Pro Glu 
            340                 345                 350         


Pro Arg Glu Gly Pro Val His Gly Gly Glu Ala Ala Arg Gly Pro Glu 
        355                 360                 365             


<210>  2855
<211>  1214
<212>  PRT
<213>  Homo sapiens

<400>  2855

Met Glu Arg Phe Arg Leu Glu Lys Lys Leu Pro Gly Pro Asp Glu Glu 
1               5                   10                  15      


Ala Val Val Asp Leu Gly Lys Thr Ser Ser Thr Val Asn Thr Lys Phe 
            20                  25                  30          


Glu Lys Glu Glu Leu Glu Ser His Arg Ala Val Tyr Ile Gly Val His 
        35                  40                  45              


Val Pro Phe Ser Lys Glu Ser Arg Arg Arg His Arg His Arg Gly His 
    50                  55                  60                  


Lys His His His Arg Arg Arg Lys Asp Lys Glu Ser Asp Lys Glu Asp 
65                  70                  75                  80  


Gly Arg Glu Ser Pro Ser Tyr Asp Thr Pro Ser Gln Arg Val Gln Phe 
                85                  90                  95      


Ile Leu Gly Thr Glu Asp Asp Asp Glu Glu His Ile Pro His Asp Leu 
            100                 105                 110         


Phe Thr Glu Met Asp Glu Leu Cys Tyr Arg Asp Gly Glu Glu Tyr Glu 
        115                 120                 125             


Trp Lys Glu Thr Ala Arg Trp Leu Lys Phe Glu Glu Asp Val Glu Asp 
    130                 135                 140                 


Gly Gly Asp Arg Trp Ser Lys Pro Tyr Val Ala Thr Leu Ser Leu His 
145                 150                 155                 160 


Ser Leu Phe Glu Leu Arg Ser Cys Ile Leu Asn Gly Thr Val Met Leu 
                165                 170                 175     


Asp Met Arg Ala Ser Thr Leu Asp Glu Ile Ala Asp Met Val Leu Asp 
            180                 185                 190         


Asn Met Ile Ala Ser Gly Gln Leu Asp Glu Ser Ile Arg Glu Asn Val 
        195                 200                 205             


Arg Glu Ala Leu Leu Lys Arg His His His Gln Asn Glu Lys Arg Phe 
    210                 215                 220                 


Thr Ser Arg Ile Pro Leu Val Arg Ser Phe Ala Asp Ile Gly Lys Lys 
225                 230                 235                 240 


His Ser Asp Pro His Leu Leu Glu Arg Asn Gly Glu Gly Leu Ser Ala 
                245                 250                 255     


Ser Arg His Ser Leu Arg Thr Gly Leu Ser Ala Ser Asn Leu Ser Leu 
            260                 265                 270         


Arg Gly Glu Ser Pro Leu Ser Leu Leu Leu Gly His Leu Leu Pro Ser 
        275                 280                 285             


Ser Arg Ala Gly Thr Pro Ala Gly Ser Arg Cys Thr Thr Pro Val Pro 
    290                 295                 300                 


Thr Pro Gln Asn Ser Pro Pro Ser Ser Pro Ser Ile Ser Arg Leu Thr 
305                 310                 315                 320 


Ser Arg Ser Ser Gln Glu Ser Gln Arg Gln Ala Pro Glu Leu Leu Val 
                325                 330                 335     


Ser Pro Ala Ser Asp Asp Ile Pro Thr Val Val Ile His Pro Pro Glu 
            340                 345                 350         


Glu Asp Leu Glu Ala Ala Leu Lys Gly Glu Glu Gln Lys Asn Glu Glu 
        355                 360                 365             


Asn Val Asp Leu Thr Pro Gly Ile Leu Ala Ser Pro Gln Ser Ala Pro 
    370                 375                 380                 


Gly Asn Leu Asp Asn Ser Lys Ser Gly Glu Ile Lys Gly Asn Gly Ser 
385                 390                 395                 400 


Gly Gly Ser Arg Glu Asn Ser Thr Val Asp Phe Ser Lys Val Asp Met 
                405                 410                 415     


Asn Phe Met Arg Lys Ile Pro Thr Gly Ala Glu Ala Ser Asn Val Leu 
            420                 425                 430         


Val Gly Glu Val Asp Phe Leu Glu Arg Pro Ile Ile Ala Phe Val Arg 
        435                 440                 445             


Leu Ala Pro Ala Val Leu Leu Thr Gly Leu Thr Glu Val Pro Val Pro 
    450                 455                 460                 


Thr Arg Phe Leu Phe Leu Leu Leu Gly Pro Ala Gly Lys Ala Pro Gln 
465                 470                 475                 480 


Tyr His Glu Ile Gly Arg Ser Ile Ala Thr Leu Met Thr Asp Glu Ile 
                485                 490                 495     


Phe His Asp Val Ala Tyr Lys Ala Lys Asp Arg Asn Asp Leu Leu Ser 
            500                 505                 510         


Gly Ile Asp Glu Phe Leu Asp Gln Val Thr Val Leu Pro Pro Gly Glu 
        515                 520                 525             


Trp Asp Pro Ser Ile Arg Ile Glu Pro Pro Lys Ser Val Pro Ser Gln 
    530                 535                 540                 


Glu Lys Arg Lys Ile Pro Val Phe His Asn Gly Ser Thr Pro Thr Leu 
545                 550                 555                 560 


Gly Glu Thr Pro Lys Glu Ala Ala His His Ala Gly Pro Glu Leu Gln 
                565                 570                 575     


Arg Thr Gly Arg Leu Phe Gly Gly Leu Ile Leu Asp Ile Lys Arg Lys 
            580                 585                 590         


Ala Pro Phe Phe Leu Ser Asp Phe Lys Asp Ala Leu Ser Leu Gln Cys 
        595                 600                 605             


Leu Ala Ser Ile Leu Phe Leu Tyr Cys Ala Cys Met Ser Pro Val Ile 
    610                 615                 620                 


Thr Phe Gly Gly Leu Leu Gly Glu Ala Thr Glu Gly Arg Ile Ser Ala 
625                 630                 635                 640 


Ile Glu Ser Leu Phe Gly Ala Ser Leu Thr Gly Ile Ala Tyr Ser Leu 
                645                 650                 655     


Phe Ala Gly Gln Pro Leu Thr Ile Leu Gly Ser Thr Gly Pro Val Leu 
            660                 665                 670         


Val Phe Glu Lys Ile Leu Tyr Lys Phe Cys Arg Asp Tyr Gln Leu Ser 
        675                 680                 685             


Tyr Leu Ser Leu Arg Thr Ser Ile Gly Leu Trp Thr Ser Phe Leu Cys 
    690                 695                 700                 


Ile Val Leu Val Ala Thr Asp Ala Ser Ser Leu Val Cys Tyr Ile Thr 
705                 710                 715                 720 


Arg Phe Thr Glu Glu Ala Phe Ala Ala Leu Ile Cys Ile Ile Phe Ile 
                725                 730                 735     


Tyr Glu Ala Leu Glu Lys Leu Phe Asp Leu Gly Glu Thr Tyr Ala Phe 
            740                 745                 750         


Asn Met His Asn Asn Leu Asp Lys Leu Thr Ser Tyr Ser Cys Val Cys 
        755                 760                 765             


Thr Glu Pro Pro Asn Pro Ser Asn Glu Thr Leu Ala Gln Trp Lys Lys 
    770                 775                 780                 


Asp Asn Ile Thr Ala His Asn Ile Ser Trp Arg Asn Leu Thr Val Ser 
785                 790                 795                 800 


Glu Cys Lys Lys Leu Arg Gly Val Phe Leu Gly Ser Ala Cys Gly His 
                805                 810                 815     


His Gly Pro Tyr Ile Pro Asp Val Leu Phe Trp Cys Val Ile Leu Phe 
            820                 825                 830         


Phe Thr Thr Phe Phe Leu Ser Ser Phe Leu Lys Gln Phe Lys Thr Lys 
        835                 840                 845             


Arg Tyr Phe Pro Thr Lys Val Arg Ser Thr Ile Ser Asp Phe Ala Val 
    850                 855                 860                 


Phe Leu Thr Ile Val Ile Met Val Thr Ile Asp Tyr Leu Val Gly Val 
865                 870                 875                 880 


Pro Ser Pro Lys Leu His Val Pro Glu Lys Phe Glu Pro Thr His Pro 
                885                 890                 895     


Glu Arg Gly Trp Ile Ile Ser Pro Leu Gly Asp Asn Pro Trp Trp Thr 
            900                 905                 910         


Leu Leu Ile Ala Ala Ile Pro Ala Leu Leu Cys Thr Ile Leu Ile Phe 
        915                 920                 925             


Met Asp Gln Gln Ile Thr Ala Val Ile Ile Asn Arg Lys Glu His Lys 
    930                 935                 940                 


Leu Lys Lys Gly Ala Gly Tyr His Leu Asp Leu Leu Met Val Gly Val 
945                 950                 955                 960 


Met Leu Gly Val Cys Ser Val Met Gly Leu Pro Trp Phe Val Ala Ala 
                965                 970                 975     


Thr Val Leu Ser Ile Ser His Val Asn Ser Leu Lys Val Glu Ser Glu 
            980                 985                 990         


Cys Ser Ala Pro Gly Glu Gln Pro  Lys Phe Leu Gly Ile  Arg Glu Gln 
        995                 1000                 1005             


Arg Val  Thr Gly Leu Met Ile  Phe Ile Leu Met Gly  Leu Ser Val 
    1010                 1015                 1020             


Phe Met  Thr Ser Val Leu Lys  Phe Ile Pro Met Pro  Val Leu Tyr 
    1025                 1030                 1035             


Gly Val  Phe Leu Tyr Met Gly  Val Ser Ser Leu Lys  Gly Ile Gln 
    1040                 1045                 1050             


Leu Phe  Asp Arg Ile Lys Leu  Phe Gly Met Pro Ala  Lys His Gln 
    1055                 1060                 1065             


Pro Asp  Leu Ile Tyr Leu Arg  Tyr Val Pro Leu Trp  Lys Val His 
    1070                 1075                 1080             


Ile Phe  Thr Val Ile Gln Leu  Thr Cys Leu Val Leu  Leu Trp Val 
    1085                 1090                 1095             


Ile Lys  Val Ser Ala Ala Ala  Val Val Phe Pro Met  Met Val Leu 
    1100                 1105                 1110             


Ala Leu  Val Phe Val Arg Lys  Leu Met Asp Leu Cys  Phe Thr Lys 
    1115                 1120                 1125             


Arg Glu  Leu Ser Trp Leu Asp  Asp Leu Met Pro Glu  Ser Lys Lys 
    1130                 1135                 1140             


Lys Lys  Glu Asp Asp Lys Lys  Lys Lys Glu Lys Glu  Glu Ala Glu 
    1145                 1150                 1155             


Arg Met  Leu Gln Asp Asp Asp  Asp Thr Val His Leu  Pro Phe Glu 
    1160                 1165                 1170             


Gly Gly  Ser Leu Leu Gln Ile  Pro Val Lys Ala Leu  Lys Tyr Ser 
    1175                 1180                 1185             


Pro Asp  Lys Pro Val Ser Val  Lys Ile Ser Phe Glu  Asp Glu Pro 
    1190                 1195                 1200             


Arg Lys  Lys Tyr Val Asp Ala  Glu Thr Ser Leu 
    1205                 1210                 


<210>  2856
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  2856

Met Ala Pro Thr Leu Gln Gln Ala Tyr Arg Arg Arg Trp Trp Met Ala 
1               5                   10                  15      


Cys Thr Ala Val Leu Glu Asn Leu Phe Phe Ser Ala Val Leu Leu Gly 
            20                  25                  30          


Trp Gly Ser Leu Leu Ile Ile Leu Lys Asn Glu Gly Phe Tyr Ser Ser 
        35                  40                  45              


Thr Cys Pro Ala Glu Ser Ser Thr Asn Thr Thr Gln Asp Glu Gln Arg 
    50                  55                  60                  


Arg Trp Pro Gly Cys Asp Gln Gln Asp Glu Met Leu Asn Leu Gly Phe 
65                  70                  75                  80  


Thr Ile Gly Ser Phe Val Leu Ser Ala Thr Thr Leu Pro Leu Gly Ile 
                85                  90                  95      


Leu Met Asp Arg Phe Gly Pro Arg Pro Val Arg Leu Val Gly Ser Ala 
            100                 105                 110         


Cys Phe Thr Ala Ser Cys Thr Leu Met Ala Leu Ala Ser Arg Asp Val 
        115                 120                 125             


Glu Ala Leu Ser Pro Leu Ile Phe Leu Ala Leu Ser Leu Asn Gly Phe 
    130                 135                 140                 


Gly Gly Ile Cys Leu Thr Phe Thr Ser Leu Thr Leu Pro Asn Met Phe 
145                 150                 155                 160 


Gly Asn Leu Arg Ser Thr Leu Met Ala Leu Met Ile Gly Ser Tyr Ala 
                165                 170                 175     


Ser Ser Ala Ile Thr Phe Pro Gly Ile Lys Leu Ile Tyr Asp Ala Gly 
            180                 185                 190         


Val Ala Phe Val Val Ile Met Phe Thr Trp Ser Gly Leu Ala Cys Leu 
        195                 200                 205             


Ile Phe Leu Asn Cys Thr Leu Asn Trp Pro Ile Glu Ala Phe Pro Ala 
    210                 215                 220                 


Pro Glu Glu Val Asn Tyr Thr Lys Lys Ile Lys Leu Ser Gly Leu Ala 
225                 230                 235                 240 


Leu Asp His Lys Val Thr Gly Asp Leu Phe Tyr Thr His Val Thr Thr 
                245                 250                 255     


Met Gly Gln Arg Leu Ser Gln Lys Ala Pro Ser Leu Glu Asp Gly Ser 
            260                 265                 270         


Asp Ala Phe Met Ser Pro Gln Asp Val Arg Gly Thr Ser Glu Asn Leu 
        275                 280                 285             


Pro Glu Arg Ser Val Pro Leu Arg Lys Ser Leu Cys Ser Pro Thr Phe 
    290                 295                 300                 


Leu Trp Ser Leu Leu Thr Met Gly Met Thr Gln Leu Arg Ile Ile Phe 
305                 310                 315                 320 


Tyr Met Ala Ala Val Asn Lys Met Leu Glu Tyr Leu Val Thr Gly Gly 
                325                 330                 335     


Gln Glu His Glu Thr Asn Glu Gln Gln Gln Lys Val Ala Glu Thr Val 
            340                 345                 350         


Gly Phe Tyr Ser Ser Val Phe Gly Ala Met Gln Leu Leu Cys Leu Leu 
        355                 360                 365             


Thr Cys Pro Leu Ile Gly Tyr Ile Met Asp Trp Arg Ile Lys Asp Cys 
    370                 375                 380                 


Val Asp Ala Pro Thr Gln Gly Thr Val Leu Gly Asp Ala Arg Asp Gly 
385                 390                 395                 400 


Val Ala Thr Lys Ser Ile Arg Pro Arg Tyr Cys Lys Ile Gln Lys Leu 
                405                 410                 415     


Thr Asn Ala Ile Ser Ala Phe Thr Leu Thr Asn Leu Leu Leu Val Gly 
            420                 425                 430         


Phe Gly Ile Thr Cys Leu Ile Asn Asn Leu His Leu Gln Phe Val Thr 
        435                 440                 445             


Phe Val Leu His Thr Ile Val Arg Gly Phe Phe His Ser Ala Cys Gly 
    450                 455                 460                 


Ser Leu Tyr Ala Ala Val Phe Pro Ser Asn His Phe Gly Thr Leu Thr 
465                 470                 475                 480 


Gly Leu Gln Ser Leu Ile Ser Ala Val Phe Ala Leu Leu Gln Gln Pro 
                485                 490                 495     


Leu Phe Met Ala Met Val Gly Pro Leu Lys Gly Glu Pro Phe Trp Val 
            500                 505                 510         


Asn Leu Gly Leu Leu Leu Phe Ser Leu Leu Gly Phe Leu Leu Pro Ser 
        515                 520                 525             


Tyr Leu Phe Tyr Tyr Arg Ala Arg Leu Gln Gln Glu Tyr Ala Ala Asn 
    530                 535                 540                 


Gly Met Gly Pro Leu Lys Val Leu Ser Gly Ser Glu Val Thr Ala 
545                 550                 555                 


<210>  2857
<211>  1384
<212>  PRT
<213>  Homo sapiens

<400>  2857

Met Met His Leu Arg Leu Phe Cys Ile Leu Leu Ala Ala Val Ser Gly 
1               5                   10                  15      


Ala Glu Gly Trp Gly Tyr Tyr Gly Cys Asp Glu Glu Leu Val Gly Pro 
            20                  25                  30          


Leu Tyr Ala Arg Ser Leu Gly Ala Ser Ser Tyr Tyr Ser Leu Leu Thr 
        35                  40                  45              


Ala Pro Arg Phe Ala Arg Leu His Gly Ile Ser Gly Trp Ser Pro Arg 
    50                  55                  60                  


Ile Gly Asp Pro Asn Pro Trp Leu Gln Ile Asp Leu Met Lys Lys His 
65                  70                  75                  80  


Arg Ile Arg Ala Val Ala Thr Gln Gly Ser Phe Asn Ser Trp Asp Trp 
                85                  90                  95      


Val Thr Arg Tyr Met Leu Leu Tyr Gly Asp Arg Val Asp Ser Trp Thr 
            100                 105                 110         


Pro Phe Tyr Gln Arg Gly His Asn Ser Thr Phe Phe Gly Asn Val Asn 
        115                 120                 125             


Glu Ser Ala Val Val Arg His Asp Leu His Phe His Phe Thr Ala Arg 
    130                 135                 140                 


Tyr Ile Arg Ile Val Pro Leu Ala Trp Asn Pro Arg Gly Lys Ile Gly 
145                 150                 155                 160 


Leu Arg Leu Gly Leu Tyr Gly Cys Pro Tyr Lys Ala Asp Ile Leu Tyr 
                165                 170                 175     


Phe Asp Gly Asp Asp Ala Ile Ser Tyr Arg Phe Pro Arg Gly Val Ser 
            180                 185                 190         


Arg Ser Leu Trp Asp Val Phe Ala Phe Ser Phe Lys Thr Glu Glu Lys 
        195                 200                 205             


Asp Gly Leu Leu Leu His Ala Glu Gly Ala Gln Gly Asp Tyr Val Thr 
    210                 215                 220                 


Leu Glu Leu Glu Gly Ala His Leu Leu Leu His Met Ser Leu Gly Ser 
225                 230                 235                 240 


Ser Pro Ile Gln Pro Arg Pro Gly His Thr Thr Val Ser Ala Gly Gly 
                245                 250                 255     


Val Leu Asn Asp Gln His Trp His Tyr Val Arg Val Asp Arg Phe Gly 
            260                 265                 270         


Arg Asp Val Asn Phe Thr Leu Asp Gly Tyr Val Gln Arg Phe Ile Leu 
        275                 280                 285             


Asn Gly Asp Phe Glu Arg Leu Asn Leu Asp Thr Glu Met Phe Ile Gly 
    290                 295                 300                 


Gly Leu Val Gly Ala Ala Arg Lys Asn Leu Ala Tyr Arg His Asn Phe 
305                 310                 315                 320 


Arg Gly Cys Ile Glu Asn Val Ile Phe Asn Arg Val Asn Ile Ala Asp 
                325                 330                 335     


Leu Ala Val Arg Arg His Ser Arg Ile Thr Phe Glu Gly Lys Val Ala 
            340                 345                 350         


Phe Arg Cys Leu Asp Pro Val Pro His Pro Ile Asn Phe Gly Gly Pro 
        355                 360                 365             


His Asn Phe Val Gln Val Pro Gly Phe Pro Arg Arg Gly Arg Leu Ala 
    370                 375                 380                 


Val Ser Phe Arg Phe Arg Thr Trp Asp Leu Thr Gly Leu Leu Leu Phe 
385                 390                 395                 400 


Ser Arg Leu Gly Asp Gly Leu Gly His Val Glu Leu Thr Leu Ser Glu 
                405                 410                 415     


Gly Gln Val Asn Val Ser Ile Ala Gln Ser Gly Arg Lys Lys Leu Gln 
            420                 425                 430         


Phe Ala Ala Gly Tyr Arg Leu Asn Asp Gly Phe Trp His Glu Val Asn 
        435                 440                 445             


Phe Val Ala Gln Glu Asn His Ala Val Ile Ser Ile Asp Asp Val Glu 
    450                 455                 460                 


Gly Ala Glu Val Arg Val Ser Tyr Pro Leu Leu Ile Arg Thr Gly Thr 
465                 470                 475                 480 


Ser Tyr Phe Phe Gly Gly Cys Pro Lys Pro Ala Ser Arg Trp Asp Cys 
                485                 490                 495     


His Ser Asn Gln Thr Ala Phe His Gly Cys Met Glu Leu Leu Lys Val 
            500                 505                 510         


Asp Gly Gln Leu Val Asn Leu Thr Leu Val Glu Gly Arg Arg Leu Gly 
        515                 520                 525             


Phe Tyr Ala Glu Val Leu Phe Asp Thr Cys Gly Ile Thr Asp Arg Cys 
    530                 535                 540                 


Ser Pro Asn Met Cys Glu His Asp Gly Arg Cys Tyr Gln Ser Trp Asp 
545                 550                 555                 560 


Asp Phe Ile Cys Tyr Cys Glu Leu Thr Gly Tyr Lys Gly Glu Thr Cys 
                565                 570                 575     


His Thr Pro Leu Tyr Lys Glu Ser Cys Glu Ala Tyr Arg Leu Ser Gly 
            580                 585                 590         


Lys Thr Ser Gly Asn Phe Thr Ile Asp Pro Asp Gly Ser Gly Pro Leu 
        595                 600                 605             


Lys Pro Phe Val Val Tyr Cys Asp Ile Arg Glu Asn Arg Ala Trp Thr 
    610                 615                 620                 


Val Val Arg His Asp Arg Leu Trp Thr Thr Arg Val Thr Gly Ser Ser 
625                 630                 635                 640 


Met Glu Arg Pro Phe Leu Gly Ala Ile Gln Tyr Trp Asn Ala Ser Trp 
                645                 650                 655     


Glu Glu Val Ser Ala Leu Ala Asn Ala Ser Gln His Cys Glu Gln Trp 
            660                 665                 670         


Ile Glu Phe Ser Cys Tyr Asn Ser Arg Leu Leu Asn Thr Ala Gly Gly 
        675                 680                 685             


Tyr Pro Tyr Ser Phe Trp Ile Gly Arg Asn Glu Glu Gln His Phe Tyr 
    690                 695                 700                 


Trp Gly Gly Ser Gln Pro Gly Ile Gln Arg Cys Ala Cys Gly Leu Asp 
705                 710                 715                 720 


Arg Ser Cys Val Asp Pro Ala Leu Tyr Cys Asn Cys Asp Ala Asp Gln 
                725                 730                 735     


Pro Gln Trp Arg Thr Asp Lys Gly Leu Leu Thr Phe Val Asp His Leu 
            740                 745                 750         


Pro Val Thr Gln Val Val Ile Gly Asp Thr Asn Arg Ser Thr Ser Glu 
        755                 760                 765             


Ala Gln Phe Phe Leu Arg Pro Leu Arg Cys Tyr Gly Asp Arg Asn Ser 
    770                 775                 780                 


Trp Asn Thr Ile Ser Phe His Thr Gly Ala Ala Leu Arg Phe Pro Pro 
785                 790                 795                 800 


Ile Arg Ala Asn His Ser Leu Asp Val Ser Phe Tyr Phe Arg Thr Ser 
                805                 810                 815     


Ala Pro Ser Gly Val Phe Leu Glu Asn Met Gly Gly Pro Tyr Cys Gln 
            820                 825                 830         


Trp Arg Arg Pro Tyr Val Arg Val Glu Leu Asn Thr Ser Arg Asp Val 
        835                 840                 845             


Val Phe Ala Phe Asp Val Gly Asn Gly Asp Glu Asn Leu Thr Val His 
    850                 855                 860                 


Ser Asp Asp Phe Glu Phe Asn Asp Asp Glu Trp His Leu Val Arg Ala 
865                 870                 875                 880 


Glu Ile Asn Val Lys Gln Ala Arg Leu Arg Val Asp His Arg Pro Trp 
                885                 890                 895     


Val Leu Arg Pro Met Pro Leu Gln Thr Tyr Ile Trp Met Glu Tyr Asp 
            900                 905                 910         


Gln Pro Leu Tyr Val Gly Ser Ala Glu Leu Lys Arg Arg Pro Phe Val 
        915                 920                 925             


Gly Cys Leu Arg Ala Met Arg Leu Asn Gly Val Thr Leu Asn Leu Glu 
    930                 935                 940                 


Gly Arg Ala Asn Ala Ser Glu Gly Thr Ser Pro Asn Cys Thr Gly His 
945                 950                 955                 960 


Cys Ala His Pro Arg Leu Pro Cys Phe His Gly Gly Arg Cys Val Glu 
                965                 970                 975     


Arg Tyr Ser Tyr Tyr Thr Cys Asp Cys Asp Leu Thr Ala Phe Asp Gly 
            980                 985                 990         


Pro Tyr Cys Asn His Asp Ile Gly  Gly Phe Phe Glu Pro  Gly Thr Trp 
        995                 1000                 1005             


Met Arg  Tyr Asn Leu Gln Ser  Ala Leu Arg Ser Ala  Ala Arg Glu 
    1010                 1015                 1020             


Phe Ser  His Met Leu Ser Arg  Pro Val Pro Gly Tyr  Glu Pro Gly 
    1025                 1030                 1035             


Tyr Ile  Pro Gly Tyr Asp Thr  Pro Gly Tyr Val Pro  Gly Tyr His 
    1040                 1045                 1050             


Gly Pro  Gly Tyr Arg Leu Pro  Asp Tyr Pro Arg Pro  Gly Arg Pro 
    1055                 1060                 1065             


Val Pro  Gly Tyr Arg Gly Pro  Val Tyr Asn Val Thr  Gly Glu Glu 
    1070                 1075                 1080             


Val Ser  Phe Ser Phe Ser Thr  Ser Ser Ala Pro Ala  Val Leu Leu 
    1085                 1090                 1095             


Tyr Val  Ser Ser Phe Val Arg  Asp Tyr Met Ala Val  Leu Ile Lys 
    1100                 1105                 1110             


Asp Asp  Gly Thr Leu Gln Leu  Arg Tyr Gln Leu Gly  Thr Ser Pro 
    1115                 1120                 1125             


Tyr Val  Tyr Gln Leu Thr Thr  Arg Pro Val Thr Asp  Gly Gln Pro 
    1130                 1135                 1140             


His Ser  Ile Asn Ile Thr Arg  Val Tyr Arg Asn Leu  Phe Ile Gln 
    1145                 1150                 1155             


Val Asp  Tyr Phe Pro Leu Thr  Glu Gln Lys Phe Ser  Leu Leu Val 
    1160                 1165                 1170             


Asp Ser  Gln Leu Asp Ser Pro  Lys Ala Leu Tyr Leu  Gly Arg Val 
    1175                 1180                 1185             


Met Glu  Thr Gly Val Ile Asp  Pro Glu Ile Gln Arg  Tyr Asn Thr 
    1190                 1195                 1200             


Pro Gly  Phe Ser Gly Cys Leu  Ser Gly Val Arg Phe  Asn Asn Val 
    1205                 1210                 1215             


Ala Pro  Leu Lys Thr His Phe  Arg Thr Pro Arg Pro  Met Thr Ala 
    1220                 1225                 1230             


Glu Leu  Ala Glu Ala Leu Arg  Val Gln Gly Glu Leu  Ser Glu Ser 
    1235                 1240                 1245             


Asn Cys  Gly Ala Met Pro Arg  Leu Val Ser Glu Val  Pro Pro Glu 
    1250                 1255                 1260             


Leu Asp  Pro Trp Tyr Leu Pro  Pro Asp Phe Pro Tyr  Tyr His Asp 
    1265                 1270                 1275             


Glu Gly  Trp Val Ala Ile Leu  Leu Gly Phe Leu Val  Ala Phe Leu 
    1280                 1285                 1290             


Leu Leu  Gly Leu Val Gly Met  Leu Val Leu Phe Tyr  Leu Gln Asn 
    1295                 1300                 1305             


His Arg  Tyr Lys Gly Ser Tyr  His Thr Asn Glu Pro  Lys Ala Ala 
    1310                 1315                 1320             


His Glu  Tyr His Pro Gly Ser  Lys Pro Pro Leu Pro  Thr Ser Gly 
    1325                 1330                 1335             


Pro Ala  Gln Val Pro Thr Pro  Thr Ala Ala Pro Asn  Gln Ala Pro 
    1340                 1345                 1350             


Ala Ser  Ala Pro Ala Pro Ala  Pro Thr Pro Ala Pro  Ala Pro Gly 
    1355                 1360                 1365             


Pro Arg  Asp Gln Asn Leu Pro  Gln Ile Leu Glu Glu  Ser Arg Ser 
    1370                 1375                 1380             


Glu 
    


<210>  2858
<211>  883
<212>  PRT
<213>  Homo sapiens

<400>  2858

Met Leu Gln Leu Trp Lys Val Val Arg Pro Ala Arg Gln Leu Glu Leu 
1               5                   10                  15      


His Arg Leu Ile Leu Leu Leu Ile Ala Phe Ser Leu Gly Ser Met Gly 
            20                  25                  30          


Phe Leu Ala Tyr Tyr Val Ser Thr Ser Pro Lys Ala Lys Glu Pro Leu 
        35                  40                  45              


Pro Leu Pro Leu Gly Asp Cys Ser Ser Gly Gly Ala Ala Gly Pro Gly 
    50                  55                  60                  


Pro Ala Arg Pro Pro Val Pro Pro Arg Pro Pro Arg Pro Pro Glu Thr 
65                  70                  75                  80  


Ala Arg Thr Glu Pro Val Val Leu Val Phe Val Glu Ser Ala Tyr Ser 
                85                  90                  95      


Gln Leu Gly Gln Glu Ile Val Ala Ile Leu Glu Ser Ser Arg Phe Arg 
            100                 105                 110         


Tyr Ser Thr Glu Leu Ala Pro Gly Arg Gly Asp Met Pro Thr Leu Thr 
        115                 120                 125             


Asp Asn Thr His Gly Arg Tyr Val Leu Val Ile Tyr Glu Asn Leu Leu 
    130                 135                 140                 


Lys Tyr Val Asn Leu Asp Ala Trp Ser Arg Glu Leu Leu Asp Arg Tyr 
145                 150                 155                 160 


Cys Val Glu Tyr Gly Val Gly Ile Ile Gly Phe Phe Arg Ala His Glu 
                165                 170                 175     


His Ser Leu Leu Ser Ala Gln Leu Lys Gly Phe Pro Leu Phe Leu His 
            180                 185                 190         


Ser Asn Leu Gly Leu Arg Asp Tyr Gln Val Asn Pro Ser Ala Pro Leu 
        195                 200                 205             


Leu His Leu Thr Arg Pro Ser Arg Leu Glu Pro Gly Pro Leu Pro Gly 
    210                 215                 220                 


Asp Asp Trp Thr Ile Phe Gln Ser Asn His Ser Thr Tyr Glu Pro Val 
225                 230                 235                 240 


Leu Leu Ala Ser Leu Arg Pro Ala Glu Pro Ala Val Pro Gly Pro Val 
                245                 250                 255     


Leu Arg Arg Ala Arg Leu Pro Thr Val Val Gln Asp Leu Gly Leu His 
            260                 265                 270         


Asp Gly Ile Gln Arg Val Leu Phe Gly His Gly Leu Ser Phe Trp Leu 
        275                 280                 285             


His Lys Leu Ile Phe Val Asp Ala Val Ala Tyr Leu Thr Gly Lys Arg 
    290                 295                 300                 


Leu Cys Leu Asp Leu Asp Arg Tyr Ile Leu Val Asp Ile Asp Asp Ile 
305                 310                 315                 320 


Phe Val Gly Lys Glu Gly Thr Arg Met Lys Val Ala Asp Val Glu Ala 
                325                 330                 335     


Leu Leu Thr Thr Gln Asn Lys Leu Arg Thr Leu Val Pro Asn Phe Thr 
            340                 345                 350         


Phe Asn Leu Gly Phe Ser Gly Lys Phe Tyr His Thr Gly Thr Glu Glu 
        355                 360                 365             


Glu Asp Ala Gly Asp Asp Met Leu Leu Lys His Arg Lys Glu Phe Trp 
    370                 375                 380                 


Trp Phe Pro His Met Trp Ser His Met Gln Pro His Leu Phe His Asn 
385                 390                 395                 400 


Arg Ser Val Leu Ala Asp Gln Met Arg Leu Asn Lys Gln Phe Ala Leu 
                405                 410                 415     


Glu His Gly Ile Pro Thr Asp Leu Gly Tyr Ala Val Ala Pro His His 
            420                 425                 430         


Ser Gly Val Tyr Pro Ile His Thr Gln Leu Tyr Glu Ala Trp Lys Ser 
        435                 440                 445             


Val Trp Gly Ile Gln Val Thr Ser Thr Glu Glu Tyr Pro His Leu Arg 
    450                 455                 460                 


Pro Ala Arg Tyr Arg Arg Gly Phe Ile His Asn Gly Ile Met Val Leu 
465                 470                 475                 480 


Pro Arg Gln Thr Cys Gly Leu Phe Thr His Thr Ile Phe Tyr Asn Glu 
                485                 490                 495     


Tyr Pro Gly Gly Ser Arg Glu Leu Asp Arg Ser Ile Arg Gly Gly Glu 
            500                 505                 510         


Leu Phe Leu Thr Val Leu Leu Asn Pro Ile Ser Ile Phe Met Thr His 
        515                 520                 525             


Leu Ser Asn Tyr Gly Asn Asp Arg Leu Gly Leu Tyr Thr Phe Glu Ser 
    530                 535                 540                 


Leu Val Arg Phe Leu Gln Cys Trp Thr Arg Leu Arg Leu Gln Thr Leu 
545                 550                 555                 560 


Pro Pro Val Pro Leu Ala Gln Lys Tyr Phe Glu Leu Phe Pro Gln Glu 
                565                 570                 575     


Arg Ser Pro Leu Trp Gln Asn Pro Cys Asp Asp Lys Arg His Lys Asp 
            580                 585                 590         


Ile Trp Ser Lys Glu Lys Thr Cys Asp Arg Leu Pro Lys Phe Leu Ile 
        595                 600                 605             


Val Gly Pro Gln Lys Thr Gly Thr Thr Ala Ile His Phe Phe Leu Ser 
    610                 615                 620                 


Leu His Pro Ala Val Thr Ser Ser Phe Pro Ser Pro Ser Thr Phe Glu 
625                 630                 635                 640 


Glu Ile Gln Phe Phe Asn Ser Pro Asn Tyr His Lys Gly Ile Asp Trp 
                645                 650                 655     


Tyr Met Asp Phe Phe Pro Val Pro Ser Asn Ala Ser Thr Asp Phe Leu 
            660                 665                 670         


Phe Glu Lys Ser Ala Thr Tyr Phe Asp Ser Glu Val Val Pro Arg Arg 
        675                 680                 685             


Gly Ala Ala Leu Leu Pro Arg Ala Lys Ile Ile Thr Val Leu Thr Asn 
    690                 695                 700                 


Pro Ala Asp Arg Ala Tyr Ser Trp Tyr Gln His Gln Arg Ala His Gly 
705                 710                 715                 720 


Asp Pro Val Ala Leu Asn Tyr Thr Phe Tyr Gln Val Ile Ser Ala Ser 
                725                 730                 735     


Ser Gln Thr Pro Leu Ala Leu Arg Ser Leu Gln Asn Arg Cys Leu Val 
            740                 745                 750         


Pro Gly Tyr Tyr Ser Thr His Leu Gln Arg Trp Leu Thr Tyr Tyr Pro 
        755                 760                 765             


Ser Gly Gln Leu Leu Ile Val Asp Gly Gln Glu Leu Arg Thr Asn Pro 
    770                 775                 780                 


Ala Ala Ser Met Glu Ser Ile Gln Lys Phe Leu Gly Ile Thr Pro Phe 
785                 790                 795                 800 


Leu Asn Tyr Thr Arg Thr Leu Arg Phe Asp Asp Asp Lys Gly Phe Trp 
                805                 810                 815     


Cys Gln Gly Leu Glu Gly Gly Lys Thr Arg Cys Leu Gly Arg Ser Lys 
            820                 825                 830         


Gly Arg Arg Tyr Pro Asp Met Asp Thr Glu Ser Arg Leu Phe Leu Thr 
        835                 840                 845             


Asp Phe Phe Arg Asn His Asn Leu Glu Leu Ser Lys Leu Leu Ser Arg 
    850                 855                 860                 


Leu Gly Gln Pro Val Pro Ser Trp Leu Arg Glu Glu Leu Gln His Ser 
865                 870                 875                 880 


Ser Leu Gly 
            


<210>  2859
<211>  1167
<212>  PRT
<213>  Homo sapiens

<400>  2859

Met Glu Leu Pro Phe Val Thr His Leu Phe Leu Pro Leu Val Phe Leu 
1               5                   10                  15      


Thr Gly Leu Cys Ser Pro Phe Asn Leu Asp Glu His His Pro Arg Leu 
            20                  25                  30          


Phe Pro Gly Pro Pro Glu Ala Glu Phe Gly Tyr Ser Val Leu Gln His 
        35                  40                  45              


Val Gly Gly Gly Gln Arg Trp Met Leu Val Gly Ala Pro Trp Asp Gly 
    50                  55                  60                  


Pro Ser Gly Asp Arg Arg Gly Asp Val Tyr Arg Cys Pro Val Gly Gly 
65                  70                  75                  80  


Ala His Asn Ala Pro Cys Ala Lys Gly His Leu Gly Asp Tyr Gln Leu 
                85                  90                  95      


Gly Asn Ser Ser His Pro Ala Val Asn Met His Leu Gly Met Ser Leu 
            100                 105                 110         


Leu Glu Thr Asp Gly Asp Gly Gly Phe Met Ala Cys Ala Pro Leu Trp 
        115                 120                 125             


Ser Arg Ala Cys Gly Ser Ser Val Phe Ser Ser Gly Ile Cys Ala Arg 
    130                 135                 140                 


Val Asp Ala Ser Phe Gln Pro Gln Gly Ser Leu Ala Pro Thr Ala Gln 
145                 150                 155                 160 


Arg Cys Pro Thr Tyr Met Asp Val Val Ile Val Leu Asp Gly Ser Asn 
                165                 170                 175     


Ser Ile Tyr Pro Trp Ser Glu Val Gln Thr Phe Leu Arg Arg Leu Val 
            180                 185                 190         


Gly Lys Leu Phe Ile Asp Pro Glu Gln Ile Gln Val Gly Leu Val Gln 
        195                 200                 205             


Tyr Gly Glu Ser Pro Val His Glu Trp Ser Leu Gly Asp Phe Arg Thr 
    210                 215                 220                 


Lys Glu Glu Val Val Arg Ala Ala Lys Asn Leu Ser Arg Arg Glu Gly 
225                 230                 235                 240 


Arg Glu Thr Lys Thr Ala Gln Ala Ile Met Val Ala Cys Thr Glu Gly 
                245                 250                 255     


Phe Ser Gln Ser His Gly Gly Arg Pro Glu Ala Ala Arg Leu Leu Val 
            260                 265                 270         


Val Val Thr Asp Gly Glu Ser His Asp Gly Glu Glu Leu Pro Ala Ala 
        275                 280                 285             


Leu Lys Ala Cys Glu Ala Gly Arg Val Thr Arg Tyr Gly Ile Ala Val 
    290                 295                 300                 


Leu Gly His Tyr Leu Arg Arg Gln Arg Asp Pro Ser Ser Phe Leu Arg 
305                 310                 315                 320 


Glu Ile Arg Thr Ile Ala Ser Asp Pro Asp Glu Arg Phe Phe Phe Asn 
                325                 330                 335     


Val Thr Asp Glu Ala Ala Leu Thr Asp Ile Val Asp Ala Leu Gly Asp 
            340                 345                 350         


Arg Ile Phe Gly Leu Glu Gly Ser His Ala Glu Asn Glu Ser Ser Phe 
        355                 360                 365             


Gly Leu Glu Met Ser Gln Ile Gly Phe Ser Thr His Arg Leu Lys Asp 
    370                 375                 380                 


Gly Ile Leu Phe Gly Met Val Gly Ala Tyr Asp Trp Gly Gly Ser Val 
385                 390                 395                 400 


Leu Trp Leu Glu Gly Gly His Arg Leu Phe Pro Pro Arg Met Ala Leu 
                405                 410                 415     


Glu Asp Glu Phe Pro Pro Ala Leu Gln Asn His Ala Ala Tyr Leu Gly 
            420                 425                 430         


Tyr Ser Val Ser Ser Met Leu Leu Arg Gly Gly Arg Arg Leu Phe Leu 
        435                 440                 445             


Ser Gly Ala Pro Arg Phe Arg His Arg Gly Lys Val Ile Ala Phe Gln 
    450                 455                 460                 


Leu Lys Lys Asp Gly Ala Val Arg Val Ala Gln Ser Leu Gln Gly Glu 
465                 470                 475                 480 


Gln Ile Gly Ser Tyr Phe Gly Ser Glu Leu Cys Pro Leu Asp Thr Asp 
                485                 490                 495     


Arg Asp Gly Thr Thr Asp Val Leu Leu Val Ala Ala Pro Met Phe Leu 
            500                 505                 510         


Gly Pro Gln Asn Lys Glu Thr Gly Arg Val Tyr Val Tyr Leu Val Gly 
        515                 520                 525             


Gln Gln Ser Leu Leu Thr Leu Gln Gly Thr Leu Gln Pro Glu Pro Pro 
    530                 535                 540                 


Gln Asp Ala Arg Phe Gly Phe Ala Met Gly Ala Leu Pro Asp Leu Asn 
545                 550                 555                 560 


Gln Asp Gly Phe Ala Asp Val Ala Val Gly Ala Pro Leu Glu Asp Gly 
                565                 570                 575     


His Gln Gly Ala Leu Tyr Leu Tyr His Gly Thr Gln Ser Gly Val Arg 
            580                 585                 590         


Pro His Pro Ala Gln Arg Ile Ala Ala Ala Ser Met Pro His Ala Leu 
        595                 600                 605             


Ser Tyr Phe Gly Arg Ser Val Asp Gly Arg Leu Asp Leu Asp Gly Asp 
    610                 615                 620                 


Asp Leu Val Asp Val Ala Val Gly Ala Gln Gly Ala Ala Ile Leu Leu 
625                 630                 635                 640 


Ser Ser Arg Pro Ile Val His Leu Thr Pro Ser Leu Glu Val Thr Pro 
                645                 650                 655     


Gln Ala Ile Ser Val Val Gln Arg Asp Cys Arg Arg Arg Gly Gln Glu 
            660                 665                 670         


Ala Val Cys Leu Thr Ala Ala Leu Cys Phe Gln Val Thr Ser Arg Thr 
        675                 680                 685             


Pro Gly Arg Trp Asp His Gln Phe Tyr Met Arg Phe Thr Ala Ser Leu 
    690                 695                 700                 


Asp Glu Trp Thr Ala Gly Ala Arg Ala Ala Phe Asp Gly Ser Gly Gln 
705                 710                 715                 720 


Arg Leu Ser Pro Arg Arg Leu Arg Leu Ser Val Gly Asn Val Thr Cys 
                725                 730                 735     


Glu Gln Leu His Phe His Val Leu Asp Thr Ser Asp Tyr Leu Arg Pro 
            740                 745                 750         


Val Ala Leu Thr Val Thr Phe Ala Leu Asp Asn Thr Thr Lys Pro Gly 
        755                 760                 765             


Pro Val Leu Asn Glu Gly Ser Pro Thr Ser Ile Gln Lys Leu Val Pro 
    770                 775                 780                 


Phe Ser Lys Asp Cys Gly Pro Asp Asn Glu Cys Val Thr Asp Leu Val 
785                 790                 795                 800 


Leu Gln Val Asn Met Asp Ile Arg Gly Ser Arg Lys Ala Pro Phe Val 
                805                 810                 815     


Val Arg Gly Gly Arg Arg Lys Val Leu Val Ser Thr Thr Leu Glu Asn 
            820                 825                 830         


Arg Lys Glu Asn Ala Tyr Asn Thr Ser Leu Ser Leu Ile Phe Ser Arg 
        835                 840                 845             


Asn Leu His Leu Ala Ser Leu Thr Pro Gln Arg Glu Ser Pro Ile Lys 
    850                 855                 860                 


Val Glu Cys Ala Ala Pro Ser Ala His Ala Arg Leu Cys Ser Val Gly 
865                 870                 875                 880 


His Pro Val Phe Gln Thr Gly Ala Lys Val Thr Phe Leu Leu Glu Phe 
                885                 890                 895     


Glu Phe Ser Cys Ser Ser Leu Leu Ser Gln Val Phe Val Lys Leu Thr 
            900                 905                 910         


Ala Ser Ser Asp Ser Leu Glu Arg Asn Gly Thr Leu Gln Asp Asn Thr 
        915                 920                 925             


Ala Gln Thr Ser Ala Tyr Ile Gln Tyr Glu Pro His Leu Leu Phe Ser 
    930                 935                 940                 


Ser Glu Ser Thr Leu His Arg Tyr Glu Val His Pro Tyr Gly Thr Leu 
945                 950                 955                 960 


Pro Val Gly Pro Gly Pro Glu Phe Lys Thr Thr Leu Arg Val Gln Asn 
                965                 970                 975     


Leu Gly Cys Tyr Val Val Ser Gly Leu Ile Ile Ser Ala Leu Leu Pro 
            980                 985                 990         


Ala Val Ala His Gly Gly Asn Tyr  Phe Leu Ser Leu Ser  Gln Val Ile 
        995                 1000                 1005             


Thr Asn  Asn Ala Ser Cys Ile  Val Gln Asn Leu Thr  Glu Pro Pro 
    1010                 1015                 1020             


Gly Pro  Pro Val His Pro Glu  Glu Leu Gln His Thr  Asn Arg Leu 
    1025                 1030                 1035             


Asn Gly  Ser Asn Thr Gln Cys  Gln Val Val Arg Cys  His Leu Gly 
    1040                 1045                 1050             


Gln Leu  Ala Lys Gly Thr Glu  Val Ser Val Gly Leu  Leu Arg Leu 
    1055                 1060                 1065             


Val His  Asn Glu Phe Phe Arg  Arg Ala Lys Phe Lys  Ser Leu Thr 
    1070                 1075                 1080             


Val Val  Ser Thr Phe Glu Leu  Gly Thr Glu Glu Gly  Ser Val Leu 
    1085                 1090                 1095             


Gln Leu  Thr Glu Ala Ser Arg  Trp Ser Glu Ser Leu  Leu Glu Val 
    1100                 1105                 1110             


Val Gln  Thr Arg Pro Ile Leu  Ile Ser Leu Trp Ile  Leu Ile Gly 
    1115                 1120                 1125             


Ser Val  Leu Gly Gly Leu Leu  Leu Leu Ala Leu Leu  Val Phe Cys 
    1130                 1135                 1140             


Leu Trp  Lys Leu Gly Phe Phe  Ala His Lys Lys Ile  Pro Glu Glu 
    1145                 1150                 1155             


Glu Lys  Arg Glu Glu Lys Leu  Glu Gln 
    1160                 1165         


<210>  2860
<211>  1063
<212>  PRT
<213>  Homo sapiens

<400>  2860

Met Ser Pro Gly Ala Ser Arg Gly Pro Arg Gly Ser Gln Ala Pro Leu 
1               5                   10                  15      


Ile Ala Pro Leu Cys Cys Ala Ala Ala Ala Leu Gly Met Leu Leu Trp 
            20                  25                  30          


Ser Pro Ala Cys Gln Ala Phe Asn Leu Asp Val Glu Lys Leu Thr Val 
        35                  40                  45              


Tyr Ser Gly Pro Lys Gly Ser Tyr Phe Gly Tyr Ala Val Asp Phe His 
    50                  55                  60                  


Ile Pro Asp Ala Arg Thr Ala Ser Val Leu Val Gly Ala Pro Lys Ala 
65                  70                  75                  80  


Asn Thr Ser Gln Pro Asp Ile Val Glu Gly Gly Ala Val Tyr Tyr Cys 
                85                  90                  95      


Pro Trp Pro Ala Glu Gly Ser Ala Gln Cys Arg Gln Ile Pro Phe Asp 
            100                 105                 110         


Thr Thr Asn Asn Arg Lys Ile Arg Val Asn Gly Thr Lys Glu Pro Ile 
        115                 120                 125             


Glu Phe Lys Ser Asn Gln Trp Phe Gly Ala Thr Val Lys Ala His Lys 
    130                 135                 140                 


Gly Lys Val Val Ala Cys Ala Pro Leu Tyr His Trp Arg Thr Leu Lys 
145                 150                 155                 160 


Pro Thr Pro Glu Lys Asp Pro Val Gly Thr Cys Tyr Val Ala Ile Gln 
                165                 170                 175     


Asn Phe Ser Ala Tyr Ala Glu Phe Ser Pro Cys Arg Asn Ser Asn Ala 
            180                 185                 190         


Asp Pro Glu Gly Gln Gly Tyr Cys Gln Ala Gly Phe Ser Leu Asp Phe 
        195                 200                 205             


Tyr Lys Asn Gly Asp Leu Ile Val Gly Gly Pro Gly Ser Phe Tyr Trp 
    210                 215                 220                 


Gln Gly Gln Val Ile Thr Ala Ser Val Ala Asp Ile Ile Ala Asn Tyr 
225                 230                 235                 240 


Ser Phe Lys Asp Ile Leu Arg Lys Leu Ala Gly Glu Lys Gln Thr Glu 
                245                 250                 255     


Val Ala Pro Ala Ser Tyr Asp Asp Ser Tyr Leu Gly Tyr Ser Val Ala 
            260                 265                 270         


Ala Gly Glu Phe Thr Gly Asp Ser Gln Gln Glu Leu Val Ala Gly Ile 
        275                 280                 285             


Pro Arg Gly Ala Gln Asn Phe Gly Tyr Val Ser Ile Ile Asn Ser Thr 
    290                 295                 300                 


Asp Met Thr Phe Ile Gln Asn Phe Thr Gly Glu Gln Met Ala Ser Tyr 
305                 310                 315                 320 


Phe Gly Tyr Thr Val Val Val Ser Asp Val Asn Ser Asp Gly Leu Asp 
                325                 330                 335     


Asp Val Leu Val Gly Ala Pro Leu Phe Met Glu Arg Glu Phe Glu Ser 
            340                 345                 350         


Asn Pro Arg Glu Val Gly Gln Ile Tyr Leu Tyr Leu Gln Val Ser Ser 
        355                 360                 365             


Leu Leu Phe Arg Asp Pro Gln Ile Leu Thr Gly Thr Glu Thr Phe Gly 
    370                 375                 380                 


Arg Phe Gly Ser Ala Met Ala His Leu Gly Asp Leu Asn Gln Asp Gly 
385                 390                 395                 400 


Tyr Asn Asp Ile Ala Ile Gly Val Pro Phe Ala Gly Lys Asp Gln Arg 
                405                 410                 415     


Gly Lys Val Leu Ile Tyr Asn Gly Asn Lys Asp Gly Leu Asn Thr Lys 
            420                 425                 430         


Pro Ser Gln Val Leu Gln Gly Val Trp Ala Ser His Ala Val Pro Ser 
        435                 440                 445             


Gly Phe Gly Phe Thr Leu Arg Gly Asp Ser Asp Ile Asp Lys Asn Asp 
    450                 455                 460                 


Tyr Pro Asp Leu Ile Val Gly Ala Phe Gly Thr Gly Lys Val Ala Val 
465                 470                 475                 480 


Tyr Arg Ala Arg Pro Val Val Thr Val Asp Ala Gln Leu Leu Leu His 
                485                 490                 495     


Pro Met Ile Ile Asn Leu Glu Asn Lys Thr Cys Gln Val Pro Asp Ser 
            500                 505                 510         


Met Thr Ser Ala Ala Cys Phe Ser Leu Arg Val Cys Ala Ser Val Thr 
        515                 520                 525             


Gly Gln Ser Ile Ala Asn Thr Ile Val Leu Met Ala Glu Val Gln Leu 
    530                 535                 540                 


Asp Ser Leu Lys Gln Lys Gly Ala Ile Lys Arg Thr Leu Phe Leu Asp 
545                 550                 555                 560 


Asn His Gln Ala His Arg Val Phe Pro Leu Val Ile Lys Arg Gln Lys 
                565                 570                 575     


Ser His Gln Cys Gln Asp Phe Ile Val Tyr Leu Arg Asp Glu Thr Glu 
            580                 585                 590         


Phe Arg Asp Lys Leu Ser Pro Ile Asn Ile Ser Leu Asn Tyr Ser Leu 
        595                 600                 605             


Asp Glu Ser Thr Phe Lys Glu Gly Leu Glu Val Lys Pro Ile Leu Asn 
    610                 615                 620                 


Tyr Tyr Arg Glu Asn Ile Val Ser Glu Gln Ala His Ile Leu Val Asp 
625                 630                 635                 640 


Cys Gly Glu Asp Asn Leu Cys Val Pro Asp Leu Lys Leu Ser Ala Arg 
                645                 650                 655     


Pro Asp Lys His Gln Val Ile Ile Gly Asp Glu Asn His Leu Met Leu 
            660                 665                 670         


Ile Ile Asn Ala Arg Asn Glu Gly Glu Gly Ala Tyr Glu Ala Glu Leu 
        675                 680                 685             


Phe Val Met Ile Pro Glu Glu Ala Asp Tyr Val Gly Ile Glu Arg Asn 
    690                 695                 700                 


Asn Lys Gly Phe Arg Pro Leu Ser Cys Glu Tyr Lys Met Glu Asn Val 
705                 710                 715                 720 


Thr Arg Met Val Val Cys Asp Leu Gly Asn Pro Met Val Ser Gly Thr 
                725                 730                 735     


Asn Tyr Ser Leu Gly Leu Arg Phe Ala Val Pro Arg Leu Glu Lys Thr 
            740                 745                 750         


Asn Met Ser Ile Asn Phe Asp Leu Gln Ile Arg Ser Ser Asn Lys Asp 
        755                 760                 765             


Asn Pro Asp Ser Asn Phe Val Ser Leu Gln Ile Asn Ile Thr Ala Val 
    770                 775                 780                 


Ala Gln Val Glu Ile Arg Gly Val Ser His Pro Pro Gln Ile Val Leu 
785                 790                 795                 800 


Pro Ile His Asn Trp Glu Pro Glu Glu Glu Pro His Lys Glu Glu Glu 
                805                 810                 815     


Val Gly Pro Leu Val Glu His Ile Tyr Glu Leu His Asn Ile Gly Pro 
            820                 825                 830         


Ser Thr Ile Ser Asp Thr Ile Leu Glu Val Gly Trp Pro Phe Ser Ala 
        835                 840                 845             


Arg Asp Glu Phe Leu Leu Tyr Ile Phe His Ile Gln Thr Leu Gly Pro 
    850                 855                 860                 


Leu Gln Cys Gln Pro Asn Pro Asn Ile Asn Pro Gln Asp Ile Lys Pro 
865                 870                 875                 880 


Ala Ala Ser Pro Glu Asp Thr Pro Glu Leu Ser Ala Phe Leu Arg Asn 
                885                 890                 895     


Ser Thr Ile Pro His Leu Val Arg Lys Arg Asp Val His Val Val Glu 
            900                 905                 910         


Phe His Arg Gln Ser Pro Ala Lys Ile Leu Asn Cys Thr Asn Ile Glu 
        915                 920                 925             


Cys Leu Gln Ile Ser Cys Ala Val Gly Arg Leu Glu Gly Gly Glu Ser 
    930                 935                 940                 


Ala Val Leu Lys Val Arg Ser Arg Leu Trp Ala His Thr Phe Leu Gln 
945                 950                 955                 960 


Arg Lys Asn Asp Pro Tyr Ala Leu Ala Ser Leu Val Ser Phe Glu Val 
                965                 970                 975     


Lys Lys Met Pro Tyr Thr Asp Gln Pro Ala Lys Leu Pro Glu Gly Ser 
            980                 985                 990         


Ile Val Ile Lys Thr Ser Val Ile  Trp Ala Thr Pro Asn  Val Ser Phe 
        995                 1000                 1005             


Ser Ile  Pro Leu Trp Val Ile  Ile Leu Ala Ile Leu  Leu Gly Leu 
    1010                 1015                 1020             


Leu Val  Leu Ala Ile Leu Thr  Leu Ala Leu Trp Lys  Cys Gly Phe 
    1025                 1030                 1035             


Phe Asp  Arg Ala Arg Pro Pro  Gln Glu Asp Met Thr  Asp Arg Glu 
    1040                 1045                 1050             


Gln Leu  Thr Asn Asp Lys Thr  Pro Glu Ala 
    1055                 1060             


<210>  2861
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  2861

Met His Lys Glu Glu His Glu Val Ala Val Leu Gly Ala Pro Pro Ser 
1               5                   10                  15      


Thr Ile Leu Pro Arg Ser Thr Val Ile Asn Ile His Ser Glu Thr Ser 
            20                  25                  30          


Val Pro Asp His Val Val Trp Ser Leu Phe Asn Thr Leu Phe Leu Asn 
        35                  40                  45              


Trp Cys Cys Leu Gly Phe Ile Ala Phe Ala Tyr Ser Val Lys Ser Arg 
    50                  55                  60                  


Asp Arg Lys Met Val Gly Asp Val Thr Gly Ala Gln Ala Tyr Ala Ser 
65                  70                  75                  80  


Thr Ala Lys Cys Leu Asn Ile Trp Ala Leu Ile Leu Gly Ile Leu Met 
                85                  90                  95      


Thr Ile Gly Phe Ile Leu Leu Leu Val Phe Gly Ser Val Thr Val Tyr 
            100                 105                 110         


His Ile Met Leu Gln Ile Ile Gln Glu Lys Arg Gly Tyr 
        115                 120                 125 


<210>  2862
<211>  620
<212>  PRT
<213>  Homo sapiens

<400>  2862

Met Leu Ser Ala Ile Tyr Thr Val Leu Ala Gly Leu Leu Phe Leu Pro 
1               5                   10                  15      


Leu Leu Val Asn Leu Cys Cys Pro Tyr Phe Phe Gln Asp Ile Gly Tyr 
            20                  25                  30          


Phe Leu Lys Val Ala Ala Val Gly Arg Arg Val Arg Ser Tyr Gly Lys 
        35                  40                  45              


Arg Arg Pro Ala Arg Thr Ile Leu Arg Ala Phe Leu Glu Lys Ala Arg 
    50                  55                  60                  


Gln Thr Pro His Lys Pro Phe Leu Leu Phe Arg Asp Glu Thr Leu Thr 
65                  70                  75                  80  


Tyr Ala Gln Val Asp Arg Arg Ser Asn Gln Val Ala Arg Ala Leu His 
                85                  90                  95      


Asp His Leu Gly Leu Arg Gln Gly Asp Cys Val Ala Leu Leu Met Gly 
            100                 105                 110         


Asn Glu Pro Ala Tyr Val Trp Leu Trp Leu Gly Leu Val Lys Leu Gly 
        115                 120                 125             


Cys Ala Met Ala Cys Leu Asn Tyr Asn Ile Arg Ala Lys Ser Leu Leu 
    130                 135                 140                 


His Cys Phe Gln Cys Cys Gly Ala Lys Val Leu Leu Val Ser Pro Glu 
145                 150                 155                 160 


Leu Gln Ala Ala Val Glu Glu Ile Leu Pro Ser Leu Lys Lys Asp Asp 
                165                 170                 175     


Val Ser Ile Tyr Tyr Val Ser Arg Thr Ser Asn Thr Asp Gly Ile Asp 
            180                 185                 190         


Ser Phe Leu Asp Lys Val Asp Glu Val Ser Thr Glu Pro Ile Pro Glu 
        195                 200                 205             


Ser Trp Arg Ser Glu Val Thr Phe Ser Thr Pro Ala Leu Tyr Ile Tyr 
    210                 215                 220                 


Thr Ser Gly Thr Thr Gly Leu Pro Lys Ala Ala Met Ile Thr His Gln 
225                 230                 235                 240 


Arg Ile Trp Tyr Gly Thr Gly Leu Thr Phe Val Ser Gly Leu Lys Ala 
                245                 250                 255     


Asp Asp Val Ile Tyr Ile Thr Leu Pro Phe Tyr His Ser Ala Ala Leu 
            260                 265                 270         


Leu Ile Gly Ile His Gly Cys Ile Val Ala Gly Ala Thr Leu Ala Leu 
        275                 280                 285             


Arg Thr Lys Phe Ser Ala Ser Gln Phe Trp Asp Asp Cys Arg Lys Tyr 
    290                 295                 300                 


Asn Val Thr Val Ile Gln Tyr Ile Gly Glu Leu Leu Arg Tyr Leu Cys 
305                 310                 315                 320 


Asn Ser Pro Gln Lys Pro Asn Asp Arg Asp His Lys Val Arg Leu Ala 
                325                 330                 335     


Leu Gly Asn Gly Leu Arg Gly Asp Val Trp Arg Gln Phe Val Lys Arg 
            340                 345                 350         


Phe Gly Asp Ile Cys Ile Tyr Glu Phe Tyr Ala Ala Thr Glu Gly Asn 
        355                 360                 365             


Ile Gly Phe Met Asn Tyr Ala Arg Lys Val Gly Ala Val Gly Arg Val 
    370                 375                 380                 


Asn Tyr Leu Gln Lys Lys Ile Ile Thr Tyr Asp Leu Ile Lys Tyr Asp 
385                 390                 395                 400 


Val Glu Lys Asp Glu Pro Val Arg Asp Glu Asn Gly Tyr Cys Val Arg 
                405                 410                 415     


Val Pro Lys Gly Glu Val Gly Leu Leu Val Cys Lys Ile Thr Gln Leu 
            420                 425                 430         


Thr Pro Phe Asn Gly Tyr Ala Gly Ala Lys Ala Gln Thr Glu Lys Lys 
        435                 440                 445             


Lys Leu Arg Asp Val Phe Lys Lys Gly Asp Leu Tyr Phe Asn Ser Gly 
    450                 455                 460                 


Asp Leu Leu Met Val Asp His Glu Asn Phe Ile Tyr Phe His Asp Arg 
465                 470                 475                 480 


Val Gly Asp Thr Phe Arg Trp Lys Gly Glu Asn Val Ala Thr Thr Glu 
                485                 490                 495     


Val Ala Asp Thr Val Gly Leu Val Asp Phe Val Gln Glu Val Asn Val 
            500                 505                 510         


Tyr Gly Val His Val Pro Asp His Glu Gly Arg Ile Gly Met Ala Ser 
        515                 520                 525             


Ile Lys Met Lys Glu Asn His Glu Phe Asp Gly Lys Lys Leu Phe Gln 
    530                 535                 540                 


His Ile Ala Asp Tyr Leu Pro Ser Tyr Ala Arg Pro Arg Phe Leu Arg 
545                 550                 555                 560 


Ile Gln Asp Thr Ile Glu Ile Thr Gly Thr Phe Lys His Arg Lys Met 
                565                 570                 575     


Thr Leu Val Glu Glu Gly Phe Asn Pro Ala Val Ile Lys Asp Ala Leu 
            580                 585                 590         


Tyr Phe Leu Asp Asp Thr Ala Lys Met Tyr Val Pro Met Thr Glu Asp 
        595                 600                 605             


Ile Tyr Asn Ala Ile Ser Ala Lys Thr Leu Lys Leu 
    610                 615                 620 


<210>  2863
<211>  567
<212>  PRT
<213>  Homo sapiens

<400>  2863

Met Glu Ala Glu Arg Arg Pro Ala Pro Gly Ser Pro Ser Glu Gly Leu 
1               5                   10                  15      


Phe Ala Asp Gly His Leu Ile Leu Trp Thr Leu Cys Ser Val Leu Leu 
            20                  25                  30          


Pro Val Phe Ile Thr Phe Trp Cys Ser Leu Gln Arg Ser Arg Arg Gln 
        35                  40                  45              


Leu His Arg Arg Asp Ile Phe Arg Lys Ser Lys His Gly Trp Arg Asp 
    50                  55                  60                  


Thr Asp Leu Phe Ser Gln Pro Thr Tyr Cys Cys Val Cys Ala Gln His 
65                  70                  75                  80  


Ile Leu Gln Gly Ala Phe Cys Asp Cys Cys Gly Leu Arg Val Asp Glu 
                85                  90                  95      


Gly Cys Leu Arg Lys Ala Asp Lys Arg Phe Gln Cys Lys Glu Ile Met 
            100                 105                 110         


Leu Lys Asn Asp Thr Lys Val Leu Asp Ala Met Pro His His Trp Ile 
        115                 120                 125             


Arg Gly Asn Val Pro Leu Cys Ser Tyr Cys Met Val Cys Lys Gln Gln 
    130                 135                 140                 


Cys Gly Cys Gln Pro Lys Leu Cys Asp Tyr Arg Cys Ile Trp Cys Gln 
145                 150                 155                 160 


Lys Thr Val His Asp Glu Cys Met Lys Asn Ser Leu Lys Asn Glu Lys 
                165                 170                 175     


Cys Asp Phe Gly Glu Phe Lys Asn Leu Ile Ile Pro Pro Ser Tyr Leu 
            180                 185                 190         


Thr Ser Ile Asn Gln Met Arg Lys Asp Lys Lys Thr Asp Tyr Glu Val 
        195                 200                 205             


Leu Ala Ser Lys Leu Gly Lys Gln Trp Thr Pro Leu Ile Ile Leu Ala 
    210                 215                 220                 


Asn Ser Arg Ser Gly Thr Asn Met Gly Glu Gly Leu Leu Gly Glu Phe 
225                 230                 235                 240 


Arg Ile Leu Leu Asn Pro Val Gln Val Phe Asp Val Thr Lys Thr Pro 
                245                 250                 255     


Pro Ile Lys Ala Leu Gln Leu Cys Thr Leu Leu Pro Tyr Tyr Ser Ala 
            260                 265                 270         


Arg Val Leu Val Cys Gly Gly Asp Gly Thr Val Gly Trp Val Leu Asp 
        275                 280                 285             


Ala Val Asp Asp Met Lys Ile Lys Gly Gln Glu Lys Tyr Ile Pro Gln 
    290                 295                 300                 


Val Ala Val Leu Pro Leu Gly Thr Gly Asn Asp Leu Ser Asn Thr Leu 
305                 310                 315                 320 


Gly Trp Gly Thr Gly Tyr Ala Gly Glu Ile Pro Val Ala Gln Val Leu 
                325                 330                 335     


Arg Asn Val Met Glu Ala Asp Gly Ile Lys Leu Asp Arg Trp Lys Val 
            340                 345                 350         


Gln Val Thr Asn Lys Gly Tyr Tyr Asn Leu Arg Lys Pro Lys Glu Phe 
        355                 360                 365             


Thr Met Asn Asn Tyr Phe Ser Val Gly Pro Asp Ala Leu Met Ala Leu 
    370                 375                 380                 


Asn Phe His Ala His Arg Glu Lys Ala Pro Ser Leu Phe Ser Ser Arg 
385                 390                 395                 400 


Ile Leu Asn Lys Ala Val Tyr Leu Phe Tyr Gly Thr Lys Asp Cys Leu 
                405                 410                 415     


Val Gln Glu Cys Lys Asp Leu Asn Lys Lys Val Glu Leu Glu Leu Asp 
            420                 425                 430         


Gly Glu Arg Val Ala Leu Pro Ser Leu Glu Gly Ile Ile Val Leu Asn 
        435                 440                 445             


Ile Gly Tyr Trp Gly Gly Gly Cys Arg Leu Trp Glu Gly Met Gly Asp 
    450                 455                 460                 


Glu Thr Tyr Pro Leu Ala Arg His Asp Asp Gly Leu Leu Glu Val Val 
465                 470                 475                 480 


Gly Val Tyr Gly Ser Phe His Cys Ala Gln Ile Gln Val Lys Leu Ala 
                485                 490                 495     


Asn Pro Phe Arg Ile Gly Gln Ala His Thr Val Arg Leu Ile Leu Lys 
            500                 505                 510         


Cys Ser Met Met Pro Met Gln Val Asp Gly Glu Pro Trp Ala Gln Gly 
        515                 520                 525             


Pro Cys Thr Val Thr Ile Thr His Lys Thr His Ala Met Met Leu Tyr 
    530                 535                 540                 


Phe Ser Gly Glu Gln Thr Asp Asp Asp Ile Ser Ser Thr Ser Asp Gln 
545                 550                 555                 560 


Glu Asp Ile Lys Ala Thr Glu 
                565         


<210>  2864
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  2864

Met Gln Cys Ser Trp Lys Ala Val Leu Leu Leu Ala Leu Ala Ser Ile 
1               5                   10                  15      


Ala Ile Gln Tyr Thr Ala Ile Arg Thr Phe Thr Ala Lys Ser Phe His 
            20                  25                  30          


Thr Cys Pro Gly Leu Ala Glu Ala Gly Leu Ala Glu Arg Leu Cys Glu 
        35                  40                  45              


Glu Ser Pro Thr Phe Ala Tyr Asn Leu Ser Arg Lys Thr His Ile Leu 
    50                  55                  60                  


Ile Leu Ala Thr Thr Arg Ser Gly Ser Ser Phe Val Gly Gln Leu Phe 
65                  70                  75                  80  


Asn Gln His Leu Asp Val Phe Tyr Leu Phe Glu Pro Leu Tyr His Val 
                85                  90                  95      


Gln Asn Thr Leu Ile Pro Arg Phe Thr Gln Gly Lys Ser Pro Ala Asp 
            100                 105                 110         


Arg Arg Val Met Leu Gly Ala Ser Arg Asp Leu Leu Arg Ser Leu Tyr 
        115                 120                 125             


Asp Cys Asp Leu Tyr Phe Leu Glu Asn Tyr Ile Lys Pro Pro Pro Val 
    130                 135                 140                 


Asn His Thr Thr Asp Arg Ile Phe Arg Arg Gly Ala Ser Arg Val Leu 
145                 150                 155                 160 


Cys Ser Arg Pro Val Cys Asp Pro Pro Gly Pro Ala Asp Leu Val Leu 
                165                 170                 175     


Glu Glu Gly Asp Cys Val Arg Lys Cys Gly Leu Leu Asn Leu Thr Val 
            180                 185                 190         


Ala Ala Glu Ala Cys Arg Glu Arg Ser His Val Ala Ile Lys Thr Val 
        195                 200                 205             


Arg Val Pro Glu Val Asn Asp Leu Arg Ala Leu Val Glu Asp Pro Arg 
    210                 215                 220                 


Leu Asn Leu Lys Val Ile Gln Leu Val Arg Asp Pro Arg Gly Ile Leu 
225                 230                 235                 240 


Ala Ser Arg Ser Glu Thr Phe Arg Asp Thr Tyr Arg Leu Trp Arg Leu 
                245                 250                 255     


Trp Tyr Gly Thr Gly Arg Lys Pro Tyr Asn Leu Asp Val Thr Gln Leu 
            260                 265                 270         


Thr Thr Val Cys Glu Asp Phe Ser Asn Ser Val Ser Thr Gly Leu Met 
        275                 280                 285             


Arg Pro Pro Trp Leu Lys Gly Lys Tyr Met Leu Val Arg Tyr Glu Asp 
    290                 295                 300                 


Leu Ala Arg Asn Pro Met Lys Lys Thr Glu Glu Ile Tyr Gly Phe Leu 
305                 310                 315                 320 


Gly Ile Pro Leu Asp Ser His Val Ala Arg Trp Ile Gln Asn Asn Thr 
                325                 330                 335     


Arg Gly Asp Pro Thr Leu Gly Lys His Lys Tyr Gly Thr Val Arg Asn 
            340                 345                 350         


Ser Ala Ala Thr Ala Glu Lys Trp Arg Phe Arg Leu Ser Tyr Asp Ile 
        355                 360                 365             


Val Ala Phe Ala Gln Asn Ala Cys Gln Gln Val Leu Ala Gln Leu Gly 
    370                 375                 380                 


Tyr Lys Ile Ala Ala Ser Glu Glu Glu Leu Lys Asn Pro Ser Val Ser 
385                 390                 395                 400 


Leu Val Glu Glu Arg Asp Phe Arg Pro Phe Ser 
                405                 410     


<210>  2865
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  2865

Met Glu Gly Ala Ala Leu Leu Arg Val Ser Val Leu Cys Ile Trp Met 
1               5                   10                  15      


Ser Ala Leu Phe Leu Gly Val Gly Val Arg Ala Glu Glu Ala Gly Ala 
            20                  25                  30          


Arg Val Gln Gln Asn Val Pro Ser Gly Thr Asp Thr Gly Asp Pro Gln 
        35                  40                  45              


Ser Lys Pro Leu Gly Asp Trp Ala Ala Gly Thr Met Asp Pro Glu Ser 
    50                  55                  60                  


Ser Ile Phe Ile Glu Asp Ala Ile Lys Tyr Phe Lys Glu Lys Val Ser 
65                  70                  75                  80  


Thr Gln Asn Leu Leu Leu Leu Leu Thr Asp Asn Glu Ala Trp Asn Gly 
                85                  90                  95      


Phe Val Ala Ala Ala Glu Leu Pro Arg Asn Glu Ala Asp Glu Leu Arg 
            100                 105                 110         


Lys Ala Leu Asp Asn Leu Ala Arg Gln Met Ile Met Lys Asp Lys Asn 
        115                 120                 125             


Trp His Asp Lys Gly Gln Gln Tyr Arg Asn Trp Phe Leu Lys Glu Phe 
    130                 135                 140                 


Pro Arg Leu Lys Ser Glu Leu Glu Asp Asn Ile Arg Arg Leu Arg Ala 
145                 150                 155                 160 


Leu Ala Asp Gly Val Gln Lys Val His Lys Gly Thr Thr Ile Ala Asn 
                165                 170                 175     


Val Val Ser Gly Ser Leu Ser Ile Ser Ser Gly Ile Leu Thr Leu Val 
            180                 185                 190         


Gly Met Gly Leu Ala Pro Phe Thr Glu Gly Gly Ser Leu Val Leu Leu 
        195                 200                 205             


Glu Pro Gly Met Glu Leu Gly Ile Thr Ala Ala Leu Thr Gly Ile Thr 
    210                 215                 220                 


Ser Ser Thr Met Asp Tyr Gly Lys Lys Trp Trp Thr Gln Ala Gln Ala 
225                 230                 235                 240 


His Asp Leu Val Ile Lys Ser Leu Asp Lys Leu Lys Glu Val Arg Glu 
                245                 250                 255     


Phe Leu Gly Glu Asn Ile Ser Asn Phe Leu Ser Leu Ala Gly Asn Thr 
            260                 265                 270         


Tyr Gln Leu Thr Arg Gly Ile Gly Lys Asp Ile Arg Ala Leu Arg Arg 
        275                 280                 285             


Ala Arg Ala Asn Leu Gln Ser Val Pro His Ala Ser Ala Ser Arg Pro 
    290                 295                 300                 


Arg Val Thr Glu Pro Ile Ser Ala Glu Ser Gly Glu Gln Val Glu Arg 
305                 310                 315                 320 


Val Asn Glu Pro Ser Ile Leu Glu Met Ser Arg Gly Val Lys Leu Thr 
                325                 330                 335     


Asp Val Ala Pro Val Ser Phe Phe Leu Val Leu Asp Val Val Tyr Leu 
            340                 345                 350         


Val Tyr Glu Ser Lys His Leu His Glu Gly Ala Lys Ser Glu Thr Ala 
        355                 360                 365             


Glu Glu Leu Lys Lys Val Ala Gln Glu Leu Glu Glu Lys Leu Asn Ile 
    370                 375                 380                 


Leu Asn Asn Asn Tyr Lys Ile Leu Gln Ala Asp Gln Glu Leu 
385                 390                 395             


<210>  2866
<211>  907
<212>  PRT
<213>  Homo sapiens

<400>  2866

Met Asp Thr Ser Arg Leu Gly Val Leu Leu Ser Leu Pro Val Leu Leu 
1               5                   10                  15      


Gln Leu Ala Thr Gly Gly Ser Ser Pro Arg Ser Gly Val Leu Leu Arg 
            20                  25                  30          


Gly Cys Pro Thr His Cys His Cys Glu Pro Asp Gly Arg Met Leu Leu 
        35                  40                  45              


Arg Val Asp Cys Ser Asp Leu Gly Leu Ser Glu Leu Pro Ser Asn Leu 
    50                  55                  60                  


Ser Val Phe Thr Ser Tyr Leu Asp Leu Ser Met Asn Asn Ile Ser Gln 
65                  70                  75                  80  


Leu Leu Pro Asn Pro Leu Pro Ser Leu Arg Phe Leu Glu Glu Leu Arg 
                85                  90                  95      


Leu Ala Gly Asn Ala Leu Thr Tyr Ile Pro Lys Gly Ala Phe Thr Gly 
            100                 105                 110         


Leu Tyr Ser Leu Lys Val Leu Met Leu Gln Asn Asn Gln Leu Arg His 
        115                 120                 125             


Val Pro Thr Glu Ala Leu Gln Asn Leu Arg Ser Leu Gln Ser Leu Arg 
    130                 135                 140                 


Leu Asp Ala Asn His Ile Ser Tyr Val Pro Pro Ser Cys Phe Ser Gly 
145                 150                 155                 160 


Leu His Ser Leu Arg His Leu Trp Leu Asp Asp Asn Ala Leu Thr Glu 
                165                 170                 175     


Ile Pro Val Gln Ala Phe Arg Ser Leu Ser Ala Leu Gln Ala Met Thr 
            180                 185                 190         


Leu Ala Leu Asn Lys Ile His His Ile Pro Asp Tyr Ala Phe Gly Asn 
        195                 200                 205             


Leu Ser Ser Leu Val Val Leu His Leu His Asn Asn Arg Ile His Ser 
    210                 215                 220                 


Leu Gly Lys Lys Cys Phe Asp Gly Leu His Ser Leu Glu Thr Leu Asp 
225                 230                 235                 240 


Leu Asn Tyr Asn Asn Leu Asp Glu Phe Pro Thr Ala Ile Arg Thr Leu 
                245                 250                 255     


Ser Asn Leu Lys Glu Leu Gly Phe His Ser Asn Asn Ile Arg Ser Ile 
            260                 265                 270         


Pro Glu Lys Ala Phe Val Gly Asn Pro Ser Leu Ile Thr Ile His Phe 
        275                 280                 285             


Tyr Asp Asn Pro Ile Gln Phe Val Gly Arg Ser Ala Phe Gln His Leu 
    290                 295                 300                 


Pro Glu Leu Arg Thr Leu Thr Leu Asn Gly Ala Ser Gln Ile Thr Glu 
305                 310                 315                 320 


Phe Pro Asp Leu Thr Gly Thr Ala Asn Leu Glu Ser Leu Thr Leu Thr 
                325                 330                 335     


Gly Ala Gln Ile Ser Ser Leu Pro Gln Thr Val Cys Asn Gln Leu Pro 
            340                 345                 350         


Asn Leu Gln Val Leu Asp Leu Ser Tyr Asn Leu Leu Glu Asp Leu Pro 
        355                 360                 365             


Ser Phe Ser Val Cys Gln Lys Leu Gln Lys Ile Asp Leu Arg His Asn 
    370                 375                 380                 


Glu Ile Tyr Glu Ile Lys Val Asp Thr Phe Gln Gln Leu Leu Ser Leu 
385                 390                 395                 400 


Arg Ser Leu Asn Leu Ala Trp Asn Lys Ile Ala Ile Ile His Pro Asn 
                405                 410                 415     


Ala Phe Ser Thr Leu Pro Ser Leu Ile Lys Leu Asp Leu Ser Ser Asn 
            420                 425                 430         


Leu Leu Ser Ser Phe Pro Ile Thr Gly Leu His Gly Leu Thr His Leu 
        435                 440                 445             


Lys Leu Thr Gly Asn His Ala Leu Gln Ser Leu Ile Ser Ser Glu Asn 
    450                 455                 460                 


Phe Pro Glu Leu Lys Val Ile Glu Met Pro Tyr Ala Tyr Gln Cys Cys 
465                 470                 475                 480 


Ala Phe Gly Val Cys Glu Asn Ala Tyr Lys Ile Ser Asn Gln Trp Asn 
                485                 490                 495     


Lys Gly Asp Asn Ser Ser Met Asp Asp Leu His Lys Lys Asp Ala Gly 
            500                 505                 510         


Met Phe Gln Ala Gln Asp Glu Arg Asp Leu Glu Asp Phe Leu Leu Asp 
        515                 520                 525             


Phe Glu Glu Asp Leu Lys Ala Leu His Ser Val Gln Cys Ser Pro Ser 
    530                 535                 540                 


Pro Gly Pro Phe Lys Pro Cys Glu His Leu Leu Asp Gly Trp Leu Ile 
545                 550                 555                 560 


Arg Ile Gly Val Trp Thr Ile Ala Val Leu Ala Leu Thr Cys Asn Ala 
                565                 570                 575     


Leu Val Thr Ser Thr Val Phe Arg Ser Pro Leu Tyr Ile Ser Pro Ile 
            580                 585                 590         


Lys Leu Leu Ile Gly Val Ile Ala Ala Val Asn Met Leu Thr Gly Val 
        595                 600                 605             


Ser Ser Ala Val Leu Ala Gly Val Asp Ala Phe Thr Phe Gly Ser Phe 
    610                 615                 620                 


Ala Arg His Gly Ala Trp Trp Glu Asn Gly Val Gly Cys His Val Ile 
625                 630                 635                 640 


Gly Phe Leu Ser Ile Phe Ala Ser Glu Ser Ser Val Phe Leu Leu Thr 
                645                 650                 655     


Leu Ala Ala Leu Glu Arg Gly Phe Ser Val Lys Tyr Ser Ala Lys Phe 
            660                 665                 670         


Glu Thr Lys Ala Pro Phe Ser Ser Leu Lys Val Ile Ile Leu Leu Cys 
        675                 680                 685             


Ala Leu Leu Ala Leu Thr Met Ala Ala Val Pro Leu Leu Gly Gly Ser 
    690                 695                 700                 


Lys Tyr Gly Ala Ser Pro Leu Cys Leu Pro Leu Pro Phe Gly Glu Pro 
705                 710                 715                 720 


Ser Thr Met Gly Tyr Met Val Ala Leu Ile Leu Leu Asn Ser Leu Cys 
                725                 730                 735     


Phe Leu Met Met Thr Ile Ala Tyr Thr Lys Leu Tyr Cys Asn Leu Asp 
            740                 745                 750         


Lys Gly Asp Leu Glu Asn Ile Trp Asp Cys Ser Met Val Lys His Ile 
        755                 760                 765             


Ala Leu Leu Leu Phe Thr Asn Cys Ile Leu Asn Cys Pro Val Ala Phe 
    770                 775                 780                 


Leu Ser Phe Ser Ser Leu Ile Asn Leu Thr Phe Ile Ser Pro Glu Val 
785                 790                 795                 800 


Ile Lys Phe Ile Leu Leu Val Val Val Pro Leu Pro Ala Cys Leu Asn 
                805                 810                 815     


Pro Leu Leu Tyr Ile Leu Phe Asn Pro His Phe Lys Glu Asp Leu Val 
            820                 825                 830         


Ser Leu Arg Lys Gln Thr Tyr Val Trp Thr Arg Ser Lys His Pro Ser 
        835                 840                 845             


Leu Met Ser Ile Asn Ser Asp Asp Val Glu Lys Gln Ser Cys Asp Ser 
    850                 855                 860                 


Thr Gln Ala Leu Val Thr Phe Thr Ser Ser Ser Ile Thr Tyr Asp Leu 
865                 870                 875                 880 


Pro Pro Ser Ser Val Pro Ser Pro Ala Tyr Pro Val Thr Glu Ser Cys 
                885                 890                 895     


His Leu Ser Ser Val Ala Phe Val Pro Cys Leu 
            900                 905         


<210>  2867
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  2867

Met Lys Arg Lys Ser Glu Arg Arg Ser Ser Trp Ala Ala Ala Pro Pro 
1               5                   10                  15      


Cys Ser Arg Arg Cys Ser Ser Thr Ser Pro Gly Val Lys Lys Ile Arg 
            20                  25                  30          


Ser Ser Thr Gln Gln Asp Pro Arg Arg Arg Asp Pro Gln Asp Asp Val 
        35                  40                  45              


Tyr Leu Asp Ile Thr Asp Arg Leu Cys Phe Ala Ile Leu Tyr Ser Arg 
    50                  55                  60                  


Pro Lys Ser Ala Ser Asn Val His Tyr Phe Ser Ile Asp Asn Glu Leu 
65                  70                  75                  80  


Glu Tyr Glu Asn Phe Tyr Ala Asp Phe Gly Pro Leu Asn Leu Ala Met 
                85                  90                  95      


Val Tyr Arg Tyr Cys Cys Lys Ile Asn Lys Lys Leu Lys Ser Ile Thr 
            100                 105                 110         


Met Leu Arg Lys Lys Ile Val His Phe Thr Gly Ser Asp Gln Arg Lys 
        115                 120                 125             


Gln Ala Asn Ala Ala Phe Leu Val Gly Cys Tyr Met Val Ile Tyr Leu 
    130                 135                 140                 


Gly Arg Thr Pro Glu Glu Ala Tyr Arg Ile Leu Ile Phe Gly Glu Thr 
145                 150                 155                 160 


Ser Tyr Ile Pro Phe Arg Asp Ala Ala Tyr Gly Ser Cys Asn Phe Tyr 
                165                 170                 175     


Ile Thr Leu Leu Asp Cys Phe His Ala Val Lys Lys Ala Met Gln Tyr 
            180                 185                 190         


Gly Phe Leu Asn Phe Asn Ser Phe Asn Leu Asp Glu Tyr Glu His Tyr 
        195                 200                 205             


Glu Lys Ala Glu Asn Gly Asp Leu Asn Trp Ile Ile Pro Asp Arg Phe 
    210                 215                 220                 


Ile Ala Phe Cys Gly Pro His Ser Arg Ala Arg Leu Glu Ser Gly Tyr 
225                 230                 235                 240 


His Gln His Ser Pro Glu Thr Tyr Ile Gln Tyr Phe Lys Asn His Asn 
                245                 250                 255     


Val Thr Thr Ile Ile Arg Leu Asn Lys Arg Met Tyr Asp Ala Lys Arg 
            260                 265                 270         


Phe Thr Asp Ala Gly Phe Asp His His Asp Leu Phe Phe Ala Asp Gly 
        275                 280                 285             


Ser Thr Pro Thr Asp Ala Ile Val Lys Glu Phe Leu Asp Ile Cys Glu 
    290                 295                 300                 


Asn Ala Glu Gly Ala Ile Ala Val His Cys Lys Ala Gly Leu Gly Arg 
305                 310                 315                 320 


Thr Gly Thr Leu Ile Ala Cys Tyr Ile Met Lys His Tyr Arg Met Thr 
                325                 330                 335     


Ala Ala Glu Thr Ile Ala Trp Val Arg Ile Cys Arg Pro Gly Ser Val 
            340                 345                 350         


Ile Gly Pro Gln Gln Gln Phe Leu Val Met Lys Gln Thr Asn Leu Trp 
        355                 360                 365             


Leu Glu Gly Asp Tyr Phe Arg Gln Lys Leu Lys Gly Gln Glu Asn Gly 
    370                 375                 380                 


Gln His Arg Ala Ala Phe Ser Lys Leu Leu Ser Gly Val Asp Asp Ile 
385                 390                 395                 400 


Ser Ile Asn Gly Val Glu Asn Gln Asp Gln Gln Glu Pro Glu Pro Tyr 
                405                 410                 415     


Ser Asp Asp Asp Glu Ile Asn Gly Val Thr Gln Gly Asp Arg Leu Arg 
            420                 425                 430         


Ala Leu Lys Ser Arg Arg Gln Ser Lys Thr Asn Ala Ile Pro Leu Thr 
        435                 440                 445             


Leu Ser Ile Ser Arg Thr Lys Thr Val Leu Arg 
    450                 455                 


<210>  2868
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  2868

Met Gly Ser Arg Val Ser Arg Glu Asp Phe Glu Trp Val Tyr Thr Asp 
1               5                   10                  15      


Gln Pro His Ala Asp Arg Arg Arg Glu Ile Leu Ala Lys Tyr Pro Glu 
            20                  25                  30          


Ile Lys Ser Leu Met Lys Pro Asp Pro Asn Leu Ile Trp Ile Ile Ile 
        35                  40                  45              


Met Met Val Leu Thr Gln Leu Gly Ala Phe Tyr Ile Val Lys Asp Leu 
    50                  55                  60                  


Asp Trp Lys Trp Val Ile Phe Gly Ala Tyr Ala Phe Gly Ser Cys Ile 
65                  70                  75                  80  


Asn His Ser Met Thr Leu Ala Ile His Glu Ile Ala His Asn Ala Ala 
                85                  90                  95      


Phe Gly Asn Cys Lys Ala Met Trp Asn Arg Trp Phe Gly Met Phe Ala 
            100                 105                 110         


Asn Leu Pro Ile Gly Ile Pro Tyr Ser Ile Ser Phe Lys Arg Tyr His 
        115                 120                 125             


Met Asp His His Arg Tyr Leu Gly Ala Asp Gly Val Asp Val Asp Ile 
    130                 135                 140                 


Pro Thr Asp Phe Glu Gly Trp Phe Phe Cys Thr Ala Phe Arg Lys Phe 
145                 150                 155                 160 


Ile Trp Val Ile Leu Gln Pro Leu Phe Tyr Ala Phe Arg Pro Leu Phe 
                165                 170                 175     


Ile Asn Pro Lys Pro Ile Thr Tyr Leu Glu Val Ile Asn Thr Val Ala 
            180                 185                 190         


Gln Val Thr Phe Asp Ile Leu Ile Tyr Tyr Phe Leu Gly Ile Lys Ser 
        195                 200                 205             


Leu Val Tyr Met Leu Ala Ala Ser Leu Leu Gly Leu Gly Leu His Pro 
    210                 215                 220                 


Ile Ser Gly His Phe Ile Ala Glu His Tyr Met Phe Leu Lys Gly His 
225                 230                 235                 240 


Glu Thr Tyr Ser Tyr Tyr Gly Pro Leu Asn Leu Leu Thr Phe Asn Val 
                245                 250                 255     


Gly Tyr His Asn Glu His His Asp Phe Pro Asn Ile Pro Gly Lys Ser 
            260                 265                 270         


Leu Pro Leu Val Arg Lys Ile Ala Ala Glu Tyr Tyr Asp Asn Leu Pro 
        275                 280                 285             


His Tyr Asn Ser Trp Ile Lys Val Leu Tyr Asp Phe Val Met Asp Asp 
    290                 295                 300                 


Thr Ile Ser Pro Tyr Ser Arg Met Lys Arg His Gln Lys Gly Glu Met 
305                 310                 315                 320 


Val Leu Glu 
            


<210>  2869
<211>  486
<212>  PRT
<213>  Homo sapiens

<400>  2869

Met Asp Ser Ser Val Ile Gln Arg Lys Lys Val Ala Val Ile Gly Gly 
1               5                   10                  15      


Gly Leu Val Gly Ser Leu Gln Ala Cys Phe Leu Ala Lys Arg Asn Phe 
            20                  25                  30          


Gln Ile Asp Val Tyr Glu Ala Arg Glu Asp Thr Arg Val Ala Thr Phe 
        35                  40                  45              


Thr Arg Gly Arg Ser Ile Asn Leu Ala Leu Ser His Arg Gly Arg Gln 
    50                  55                  60                  


Ala Leu Lys Ala Val Gly Leu Glu Asp Gln Ile Val Ser Gln Gly Ile 
65                  70                  75                  80  


Pro Met Arg Ala Arg Met Ile His Ser Leu Ser Gly Lys Lys Ser Ala 
                85                  90                  95      


Ile Pro Tyr Gly Thr Lys Ser Gln Tyr Ile Leu Ser Val Ser Arg Glu 
            100                 105                 110         


Asn Leu Asn Lys Asp Leu Leu Thr Ala Ala Glu Lys Tyr Pro Asn Val 
        115                 120                 125             


Lys Met His Phe Asn His Arg Leu Leu Lys Cys Asn Pro Glu Glu Gly 
    130                 135                 140                 


Met Ile Thr Val Leu Gly Ser Asp Lys Val Pro Lys Asp Val Thr Cys 
145                 150                 155                 160 


Asp Leu Ile Val Gly Cys Asp Gly Ala Tyr Ser Thr Val Arg Ser His 
                165                 170                 175     


Leu Met Lys Lys Pro Arg Phe Asp Tyr Ser Gln Gln Tyr Ile Pro His 
            180                 185                 190         


Gly Tyr Met Glu Leu Thr Ile Pro Pro Lys Asn Gly Asp Tyr Ala Met 
        195                 200                 205             


Glu Pro Asn Tyr Leu His Ile Trp Pro Arg Asn Thr Phe Met Met Ile 
    210                 215                 220                 


Ala Leu Pro Asn Met Asn Lys Ser Phe Thr Cys Thr Leu Phe Met Pro 
225                 230                 235                 240 


Phe Glu Glu Phe Glu Lys Leu Leu Thr Ser Asn Asp Val Val Asp Phe 
                245                 250                 255     


Phe Gln Lys Tyr Phe Pro Asp Ala Ile Pro Leu Ile Gly Glu Lys Leu 
            260                 265                 270         


Leu Val Gln Asp Phe Phe Leu Leu Pro Ala Gln Pro Met Ile Ser Val 
        275                 280                 285             


Lys Cys Ser Ser Phe His Phe Lys Ser His Cys Val Leu Leu Gly Asp 
    290                 295                 300                 


Ala Ala His Ala Ile Val Pro Phe Phe Gly Gln Gly Met Asn Ala Gly 
305                 310                 315                 320 


Phe Glu Asp Cys Leu Val Phe Asp Glu Leu Met Asp Lys Phe Ser Asn 
                325                 330                 335     


Asp Leu Ser Leu Cys Leu Pro Val Phe Ser Arg Leu Arg Ile Pro Asp 
            340                 345                 350         


Asp His Ala Ile Ser Asp Leu Ser Met Tyr Asn Tyr Ile Glu Met Arg 
        355                 360                 365             


Ala His Val Asn Ser Ser Trp Phe Ile Phe Gln Lys Asn Met Glu Arg 
    370                 375                 380                 


Phe Leu His Ala Ile Met Pro Ser Thr Phe Ile Pro Leu Tyr Thr Met 
385                 390                 395                 400 


Val Thr Phe Ser Arg Ile Arg Tyr His Glu Ala Val Gln Arg Trp His 
                405                 410                 415     


Trp Gln Lys Lys Val Ile Asn Lys Gly Leu Phe Phe Leu Gly Ser Leu 
            420                 425                 430         


Ile Ala Ile Ser Ser Thr Tyr Leu Leu Ile His Tyr Met Ser Pro Arg 
        435                 440                 445             


Ser Phe Leu Arg Leu Arg Arg Pro Trp Asn Trp Ile Ala His Phe Arg 
    450                 455                 460                 


Asn Thr Thr Cys Phe Pro Ala Lys Ala Val Asp Ser Leu Glu Gln Ile 
465                 470                 475                 480 


Ser Asn Leu Ile Ser Arg 
                485     


<210>  2870
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  2870

Met Arg Thr Ala Leu Leu Leu Leu Ala Ala Leu Ala Val Ala Thr Gly 
1               5                   10                  15      


Pro Ala Leu Thr Leu Arg Cys His Val Cys Thr Ser Ser Ser Asn Cys 
            20                  25                  30          


Lys His Ser Val Val Cys Pro Ala Ser Ser Arg Phe Cys Lys Thr Thr 
        35                  40                  45              


Asn Thr Val Glu Pro Leu Arg Gly Asn Leu Val Lys Lys Asp Cys Ala 
    50                  55                  60                  


Glu Ser Cys Thr Pro Ser Tyr Thr Leu Gln Gly Gln Val Ser Ser Gly 
65                  70                  75                  80  


Thr Ser Ser Thr Gln Cys Cys Gln Glu Asp Leu Cys Asn Glu Lys Leu 
                85                  90                  95      


His Asn Ala Ala Pro Thr Arg Thr Ala Leu Ala His Ser Ala Leu Ser 
            100                 105                 110         


Leu Gly Leu Ala Leu Ser Leu Leu Ala Val Ile Leu Ala Pro Ser Leu 
        115                 120                 125             


<210>  2871
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  2871

Met Arg Arg Ala Ser Arg Asp Tyr Thr Lys Tyr Leu Arg Gly Ser Glu 
1               5                   10                  15      


Glu Met Gly Gly Gly Pro Gly Ala Pro His Glu Gly Pro Leu His Ala 
            20                  25                  30          


Pro Pro Pro Pro Ala Pro His Gln Pro Pro Ala Ala Ser Arg Ser Met 
        35                  40                  45              


Phe Val Ala Leu Leu Gly Leu Gly Leu Gly Gln Val Val Cys Ser Val 
    50                  55                  60                  


Ala Leu Phe Phe Tyr Phe Arg Ala Gln Met Asp Pro Asn Arg Ile Ser 
65                  70                  75                  80  


Glu Asp Gly Thr His Cys Ile Tyr Arg Ile Leu Arg Leu His Glu Asn 
                85                  90                  95      


Ala Asp Phe Gln Asp Thr Thr Leu Glu Ser Gln Asp Thr Lys Leu Ile 
            100                 105                 110         


Pro Asp Ser Cys Arg Arg Ile Lys Gln Ala Phe Gln Gly Ala Val Gln 
        115                 120                 125             


Lys Glu Leu Gln His Ile Val Gly Ser Gln His Ile Arg Ala Glu Lys 
    130                 135                 140                 


Ala Met Val Asp Gly Ser Trp Leu Asp Leu Ala Lys Arg Ser Lys Leu 
145                 150                 155                 160 


Glu Ala Gln Pro Phe Ala His Leu Thr Ile Asn Ala Thr Asp Ile Pro 
                165                 170                 175     


Ser Gly Ser His Lys Val Ser Leu Ser Ser Trp Tyr His Asp Arg Gly 
            180                 185                 190         


Trp Ala Lys Ile Ser Asn Met Thr Phe Ser Asn Gly Lys Leu Ile Val 
        195                 200                 205             


Asn Gln Asp Gly Phe Tyr Tyr Leu Tyr Ala Asn Ile Cys Phe Arg His 
    210                 215                 220                 


His Glu Thr Ser Gly Asp Leu Ala Thr Glu Tyr Leu Gln Leu Met Val 
225                 230                 235                 240 


Tyr Val Thr Lys Thr Ser Ile Lys Ile Pro Ser Ser His Thr Leu Met 
                245                 250                 255     


Lys Gly Gly Ser Thr Lys Tyr Trp Ser Gly Asn Ser Glu Phe His Phe 
            260                 265                 270         


Tyr Ser Ile Asn Val Gly Gly Phe Phe Lys Leu Arg Ser Gly Glu Glu 
        275                 280                 285             


Ile Ser Ile Glu Val Ser Asn Pro Ser Leu Leu Asp Pro Asp Gln Asp 
    290                 295                 300                 


Ala Thr Tyr Phe Gly Ala Phe Lys Val Arg Asp Ile Asp 
305                 310                 315         


<210>  2872
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  2872

Met Ala Pro Ala Arg Thr Met Ala Arg Ala Arg Leu Ala Pro Ala Gly 
1               5                   10                  15      


Ile Pro Ala Val Ala Leu Trp Leu Leu Cys Thr Leu Gly Leu Gln Gly 
            20                  25                  30          


Thr Gln Ala Gly Pro Pro Pro Ala Pro Pro Gly Leu Pro Ala Gly Ala 
        35                  40                  45              


Asp Cys Leu Asn Ser Phe Thr Ala Gly Val Pro Gly Phe Val Leu Asp 
    50                  55                  60                  


Thr Asn Ala Ser Val Ser Asn Gly Ala Thr Phe Leu Glu Ser Pro Thr 
65                  70                  75                  80  


Val Arg Arg Gly Trp Asp Cys Val Arg Ala Cys Cys Thr Thr Gln Asn 
                85                  90                  95      


Cys Asn Leu Ala Leu Val Glu Leu Gln Pro Asp Arg Gly Glu Asp Ala 
            100                 105                 110         


Ile Ala Ala Cys Phe Leu Ile Asn Cys Leu Tyr Glu Gln Asn Phe Val 
        115                 120                 125             


Cys Lys Phe Ala Pro Arg Glu Gly Phe Ile Asn Tyr Leu Thr Arg Glu 
    130                 135                 140                 


Val Tyr Arg Ser Tyr Arg Gln Leu Arg Thr Gln Gly Phe Gly Gly Ser 
145                 150                 155                 160 


Gly Ile Pro Lys Ala Trp Ala Gly Ile Asp Leu Lys Val Gln Pro Gln 
                165                 170                 175     


Glu Pro Leu Val Leu Lys Asp Val Glu Asn Thr Asp Trp Arg Leu Leu 
            180                 185                 190         


Arg Gly Asp Thr Asp Val Arg Val Glu Arg Lys Asp Pro Asn Gln Val 
        195                 200                 205             


Glu Leu Trp Gly Leu Lys Glu Gly Thr Tyr Leu Phe Gln Leu Thr Val 
    210                 215                 220                 


Thr Ser Ser Asp His Pro Glu Asp Thr Ala Asn Val Thr Val Thr Val 
225                 230                 235                 240 


Leu Ser Thr Lys Gln Thr Glu Asp Tyr Cys Leu Ala Ser Asn Lys Val 
                245                 250                 255     


Gly Arg Cys Arg Gly Ser Phe Pro Arg Trp Tyr Tyr Asp Pro Thr Glu 
            260                 265                 270         


Gln Ile Cys Lys Ser Phe Val Tyr Gly Gly Cys Leu Gly Asn Lys Asn 
        275                 280                 285             


Asn Tyr Leu Arg Glu Glu Glu Cys Ile Leu Ala Cys Arg Gly Val Gln 
    290                 295                 300                 


Gly Pro Ser Met Glu Arg Arg His Pro Val Cys Ser Gly Thr Cys Gln 
305                 310                 315                 320 


Pro Thr Gln Phe Arg Cys Ser Asn Gly Cys Cys Ile Asp Ser Phe Leu 
                325                 330                 335     


Glu Cys Asp Asp Thr Pro Asn Cys Pro Asp Ala Ser Asp Glu Ala Ala 
            340                 345                 350         


Cys Glu Lys Tyr Thr Ser Gly Phe Asp Glu Leu Gln Arg Ile His Phe 
        355                 360                 365             


Pro Ser Asp Lys Gly His Cys Val Asp Leu Pro Asp Thr Gly Leu Cys 
    370                 375                 380                 


Lys Glu Ser Ile Pro Arg Trp Tyr Tyr Asn Pro Phe Ser Glu His Cys 
385                 390                 395                 400 


Ala Arg Phe Thr Tyr Gly Gly Cys Tyr Gly Asn Lys Asn Asn Phe Glu 
                405                 410                 415     


Glu Glu Gln Gln Cys Leu Glu Ser Cys Arg Gly Ile Ser Lys Lys Asp 
            420                 425                 430         


Val Phe Gly Leu Arg Arg Glu Ile Pro Ile Pro Ser Thr Gly Ser Val 
        435                 440                 445             


Glu Met Ala Val Ala Val Phe Leu Val Ile Cys Ile Val Val Val Val 
    450                 455                 460                 


Ala Ile Leu Gly Tyr Cys Phe Phe Lys Asn Gln Arg Lys Asp Phe His 
465                 470                 475                 480 


Gly His His His His Pro Pro Pro Thr Pro Ala Ser Ser Thr Val Ser 
                485                 490                 495     


Thr Thr Glu Asp Thr Glu His Leu Val Tyr Asn His Thr Thr Arg Pro 
            500                 505                 510         


Leu 
    


<210>  2873
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  2873

Met Phe Asp Lys Thr Arg Leu Pro Tyr Val Ala Leu Asp Val Leu Cys 
1               5                   10                  15      


Val Leu Leu Ala Gly Leu Pro Phe Ala Ile Leu Thr Ser Arg His Thr 
            20                  25                  30          


Pro Phe Gln Arg Gly Val Phe Cys Asn Asp Glu Ser Ile Lys Tyr Pro 
        35                  40                  45              


Tyr Lys Glu Asp Thr Ile Pro Tyr Ala Leu Leu Gly Gly Ile Ile Ile 
    50                  55                  60                  


Pro Phe Ser Ile Ile Val Ile Ile Leu Gly Glu Thr Leu Ser Val Tyr 
65                  70                  75                  80  


Cys Asn Leu Leu His Ser Asn Ser Phe Ile Arg Asn Asn Tyr Ile Ala 
                85                  90                  95      


Thr Ile Tyr Lys Ala Ile Gly Thr Phe Leu Phe Gly Ala Ala Ala Ser 
            100                 105                 110         


Gln Ser Leu Thr Asp Ile Ala Lys Tyr Ser Ile Gly Arg Leu Arg Pro 
        115                 120                 125             


His Phe Leu Asp Val Cys Asp Pro Asp Trp Ser Lys Ile Asn Cys Ser 
    130                 135                 140                 


Asp Gly Tyr Ile Glu Tyr Tyr Ile Cys Arg Gly Asn Ala Glu Arg Val 
145                 150                 155                 160 


Lys Glu Gly Arg Leu Ser Phe Tyr Ser Gly His Ser Ser Phe Ser Met 
                165                 170                 175     


Tyr Cys Met Leu Phe Val Ala Leu Tyr Leu Gln Ala Arg Met Lys Gly 
            180                 185                 190         


Asp Trp Ala Arg Leu Leu Arg Pro Thr Leu Gln Phe Gly Leu Val Ala 
        195                 200                 205             


Val Ser Ile Tyr Val Gly Leu Ser Arg Val Ser Asp Tyr Lys His His 
    210                 215                 220                 


Trp Ser Asp Val Leu Thr Gly Leu Ile Gln Gly Ala Leu Val Ala Ile 
225                 230                 235                 240 


Leu Val Ala Val Tyr Val Ser Asp Phe Phe Lys Glu Arg Thr Ser Phe 
                245                 250                 255     


Lys Glu Arg Lys Glu Glu Asp Ser His Thr Thr Leu His Glu Thr Pro 
            260                 265                 270         


Thr Thr Gly Asn His Tyr Pro Ser Asn His Gln Pro 
        275                 280                 


<210>  2874
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  2874

Met Gln Arg Arg Trp Val Phe Val Leu Leu Asp Val Leu Cys Leu Leu 
1               5                   10                  15      


Val Ala Ser Leu Pro Phe Ala Ile Leu Thr Leu Val Asn Ala Pro Tyr 
            20                  25                  30          


Lys Arg Gly Phe Tyr Cys Gly Asp Asp Ser Ile Arg Tyr Pro Tyr Arg 
        35                  40                  45              


Pro Asp Thr Ile Thr His Gly Leu Met Ala Gly Val Thr Ile Thr Ala 
    50                  55                  60                  


Thr Val Ile Leu Val Ser Ala Gly Glu Ala Tyr Leu Val Tyr Thr Asp 
65                  70                  75                  80  


Arg Leu Tyr Ser Arg Ser Asp Phe Asn Asn Tyr Val Ala Ala Val Tyr 
                85                  90                  95      


Lys Val Leu Gly Thr Phe Leu Phe Gly Ala Ala Val Ser Gln Ser Leu 
            100                 105                 110         


Thr Asp Leu Ala Lys Tyr Met Ile Gly Arg Leu Arg Pro Asn Phe Leu 
        115                 120                 125             


Ala Val Cys Asp Pro Asp Trp Ser Arg Val Asn Cys Ser Val Tyr Val 
    130                 135                 140                 


Gln Leu Glu Lys Val Cys Arg Gly Asn Pro Ala Asp Val Thr Glu Ala 
145                 150                 155                 160 


Arg Leu Ser Phe Tyr Ser Gly His Ser Ser Phe Gly Met Tyr Cys Met 
                165                 170                 175     


Val Phe Leu Ala Leu Tyr Val Gln Ala Arg Leu Cys Trp Lys Trp Ala 
            180                 185                 190         


Arg Leu Leu Arg Pro Thr Val Gln Phe Phe Leu Val Ala Phe Ala Leu 
        195                 200                 205             


Tyr Val Gly Tyr Thr Arg Val Ser Asp Tyr Lys His His Trp Ser Asp 
    210                 215                 220                 


Val Leu Val Gly Leu Leu Gln Gly Ala Leu Val Ala Ala Leu Thr Val 
225                 230                 235                 240 


Cys Tyr Ile Ser Asp Phe Phe Lys Ala Arg Pro Pro Gln His Cys Leu 
                245                 250                 255     


Lys Glu Glu Glu Leu Glu Arg Lys Pro Ser Leu Ser Leu Thr Leu Thr 
            260                 265                 270         


Leu Gly Glu Ala Asp His Asn His Tyr Gly Tyr Pro His Ser Ser Ser 
        275                 280                 285             


<210>  2875
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  2875

Met Gln Asn Tyr Lys Tyr Asp Lys Ala Ile Val Pro Glu Ser Lys Asn 
1               5                   10                  15      


Gly Gly Ser Pro Ala Leu Asn Asn Asn Pro Arg Arg Ser Gly Ser Lys 
            20                  25                  30          


Arg Val Leu Leu Ile Cys Leu Asp Leu Phe Cys Leu Phe Met Ala Gly 
        35                  40                  45              


Leu Pro Phe Leu Ile Ile Glu Thr Ser Thr Ile Lys Pro Tyr His Arg 
    50                  55                  60                  


Gly Phe Tyr Cys Asn Asp Glu Ser Ile Lys Tyr Pro Leu Lys Thr Gly 
65                  70                  75                  80  


Glu Thr Ile Asn Asp Ala Val Leu Cys Ala Val Gly Ile Val Ile Ala 
                85                  90                  95      


Ile Leu Ala Ile Ile Thr Gly Glu Phe Tyr Arg Ile Tyr Tyr Leu Lys 
            100                 105                 110         


Lys Ser Arg Ser Thr Ile Gln Asn Pro Tyr Val Ala Ala Leu Tyr Lys 
        115                 120                 125             


Gln Val Gly Cys Phe Leu Phe Gly Cys Ala Ile Ser Gln Ser Phe Thr 
    130                 135                 140                 


Asp Ile Ala Lys Val Ser Ile Gly Arg Leu Arg Pro His Phe Leu Ser 
145                 150                 155                 160 


Val Cys Asn Pro Asp Phe Ser Gln Ile Asn Cys Ser Glu Gly Tyr Ile 
                165                 170                 175     


Gln Asn Tyr Arg Cys Arg Gly Asp Asp Ser Lys Val Gln Glu Ala Arg 
            180                 185                 190         


Lys Ser Phe Phe Ser Gly His Ala Ser Phe Ser Met Tyr Thr Met Leu 
        195                 200                 205             


Tyr Leu Val Leu Tyr Leu Gln Ala Arg Phe Thr Trp Arg Gly Ala Arg 
    210                 215                 220                 


Leu Leu Arg Pro Leu Leu Gln Phe Thr Leu Ile Met Met Ala Phe Tyr 
225                 230                 235                 240 


Thr Gly Leu Ser Arg Val Ser Asp His Lys His His Pro Ser Asp Val 
                245                 250                 255     


Leu Ala Gly Phe Ala Gln Gly Ala Leu Val Ala Cys Cys Ile Val Phe 
            260                 265                 270         


Phe Val Ser Asp Leu Phe Lys Thr Lys Thr Thr Leu Ser Leu Pro Ala 
        275                 280                 285             


Pro Ala Ile Arg Lys Glu Ile Leu Ser Pro Val Asp Ile Ile Asp Arg 
    290                 295                 300                 


Asn Asn His His Asn Met Met 
305                 310     


<210>  2876
<211>  931
<212>  PRT
<213>  Homo sapiens

<400>  2876

Met Arg Lys Gly Leu Arg Ala Thr Ala Ala Arg Cys Gly Leu Gly Leu 
1               5                   10                  15      


Gly Tyr Leu Leu Gln Met Leu Val Leu Pro Ala Leu Ala Leu Leu Ser 
            20                  25                  30          


Ala Ser Gly Thr Gly Ser Ala Ala Gln Asp Asp Asp Phe Phe His Glu 
        35                  40                  45              


Leu Pro Glu Thr Phe Pro Ser Asp Pro Pro Glu Pro Leu Pro His Phe 
    50                  55                  60                  


Leu Ile Glu Pro Glu Glu Ala Tyr Ile Val Lys Asn Lys Pro Val Asn 
65                  70                  75                  80  


Leu Tyr Cys Lys Ala Ser Pro Ala Thr Gln Ile Tyr Phe Lys Cys Asn 
                85                  90                  95      


Ser Glu Trp Val His Gln Lys Asp His Ile Val Asp Glu Arg Val Asp 
            100                 105                 110         


Glu Thr Ser Gly Leu Ile Val Arg Glu Val Ser Ile Glu Ile Ser Arg 
        115                 120                 125             


Gln Gln Val Glu Glu Leu Phe Gly Pro Glu Asp Tyr Trp Cys Gln Cys 
    130                 135                 140                 


Val Ala Trp Ser Ser Ala Gly Thr Thr Lys Ser Arg Lys Ala Tyr Val 
145                 150                 155                 160 


Arg Ile Ala Tyr Leu Arg Lys Thr Phe Glu Gln Glu Pro Leu Gly Lys 
                165                 170                 175     


Glu Val Ser Leu Glu Gln Glu Val Leu Leu Gln Cys Arg Pro Pro Glu 
            180                 185                 190         


Gly Ile Pro Val Ala Glu Val Glu Trp Leu Lys Asn Glu Asp Ile Ile 
        195                 200                 205             


Asp Pro Val Glu Asp Arg Asn Phe Tyr Ile Thr Ile Asp His Asn Leu 
    210                 215                 220                 


Ile Ile Lys Gln Ala Arg Leu Ser Asp Thr Ala Asn Tyr Thr Cys Val 
225                 230                 235                 240 


Ala Lys Asn Ile Val Ala Lys Arg Lys Ser Thr Thr Ala Thr Val Ile 
                245                 250                 255     


Val Tyr Val Asn Gly Gly Trp Ser Thr Trp Thr Glu Trp Ser Val Cys 
            260                 265                 270         


Asn Ser Arg Cys Gly Arg Gly Tyr Gln Lys Arg Thr Arg Thr Cys Thr 
        275                 280                 285             


Asn Pro Ala Pro Leu Asn Gly Gly Ala Phe Cys Glu Gly Gln Ser Val 
    290                 295                 300                 


Gln Lys Ile Ala Cys Thr Thr Leu Cys Pro Val Asp Gly Arg Trp Thr 
305                 310                 315                 320 


Pro Trp Ser Lys Trp Ser Thr Cys Gly Thr Glu Cys Thr His Trp Arg 
                325                 330                 335     


Arg Arg Glu Cys Thr Ala Pro Ala Pro Lys Asn Gly Gly Lys Asp Cys 
            340                 345                 350         


Asp Gly Leu Val Leu Gln Ser Lys Asn Cys Thr Asp Gly Leu Cys Met 
        355                 360                 365             


Gln Thr Ala Pro Asp Ser Asp Asp Val Ala Leu Tyr Val Gly Ile Val 
    370                 375                 380                 


Ile Ala Val Ile Val Cys Leu Ala Ile Ser Val Val Val Ala Leu Phe 
385                 390                 395                 400 


Val Tyr Arg Lys Asn His Arg Asp Phe Glu Ser Asp Ile Ile Asp Ser 
                405                 410                 415     


Ser Ala Leu Asn Gly Gly Phe Gln Pro Val Asn Ile Lys Ala Ala Arg 
            420                 425                 430         


Gln Asp Leu Leu Ala Val Pro Pro Asp Leu Thr Ser Ala Ala Ala Met 
        435                 440                 445             


Tyr Arg Gly Pro Val Tyr Ala Leu His Asp Val Ser Asp Lys Ile Pro 
    450                 455                 460                 


Met Thr Asn Ser Pro Ile Leu Asp Pro Leu Pro Asn Leu Lys Ile Lys 
465                 470                 475                 480 


Val Tyr Asn Thr Ser Gly Ala Val Thr Pro Gln Asp Asp Leu Ser Glu 
                485                 490                 495     


Phe Thr Ser Lys Leu Ser Pro Gln Met Thr Gln Ser Leu Leu Glu Asn 
            500                 505                 510         


Glu Ala Leu Ser Leu Lys Asn Gln Ser Leu Ala Arg Gln Thr Asp Pro 
        515                 520                 525             


Ser Cys Thr Ala Phe Gly Ser Phe Asn Ser Leu Gly Gly His Leu Ile 
    530                 535                 540                 


Val Pro Asn Ser Gly Val Ser Leu Leu Ile Pro Ala Gly Ala Ile Pro 
545                 550                 555                 560 


Gln Gly Arg Val Tyr Glu Met Tyr Val Thr Val His Arg Lys Glu Thr 
                565                 570                 575     


Met Arg Pro Pro Met Asp Asp Ser Gln Thr Leu Leu Thr Pro Val Val 
            580                 585                 590         


Ser Cys Gly Pro Pro Gly Ala Leu Leu Thr Arg Pro Val Val Leu Thr 
        595                 600                 605             


Met His His Cys Ala Asp Pro Asn Thr Glu Asp Trp Lys Ile Leu Leu 
    610                 615                 620                 


Lys Asn Gln Ala Ala Gln Gly Gln Trp Glu Asp Val Val Val Val Gly 
625                 630                 635                 640 


Glu Glu Asn Phe Thr Thr Pro Cys Tyr Ile Gln Leu Asp Ala Glu Ala 
                645                 650                 655     


Cys His Ile Leu Thr Glu Asn Leu Ser Thr Tyr Ala Leu Val Gly His 
            660                 665                 670         


Ser Thr Thr Lys Ala Ala Ala Lys Arg Leu Lys Leu Ala Ile Phe Gly 
        675                 680                 685             


Pro Leu Cys Cys Ser Ser Leu Glu Tyr Ser Ile Arg Val Tyr Cys Leu 
    690                 695                 700                 


Asp Asp Thr Gln Asp Ala Leu Lys Glu Ile Leu His Leu Glu Arg Gln 
705                 710                 715                 720 


Met Gly Gly Gln Leu Leu Glu Glu Pro Lys Ala Leu His Phe Lys Gly 
                725                 730                 735     


Ser Thr His Asn Leu Arg Leu Ser Ile His Asp Ile Ala His Ser Leu 
            740                 745                 750         


Trp Lys Ser Lys Leu Leu Ala Lys Tyr Gln Glu Ile Pro Phe Tyr His 
        755                 760                 765             


Val Trp Ser Gly Ser Gln Arg Asn Leu His Cys Thr Phe Thr Leu Glu 
    770                 775                 780                 


Arg Phe Ser Leu Asn Thr Val Glu Leu Val Cys Lys Leu Cys Val Arg 
785                 790                 795                 800 


Gln Val Glu Gly Glu Gly Gln Ile Phe Gln Leu Asn Cys Thr Val Ser 
                805                 810                 815     


Glu Glu Pro Thr Gly Ile Asp Leu Pro Leu Leu Asp Pro Ala Asn Thr 
            820                 825                 830         


Ile Thr Thr Val Thr Gly Pro Ser Ala Phe Ser Ile Pro Leu Pro Ile 
        835                 840                 845             


Arg Gln Lys Leu Cys Ser Ser Leu Asp Ala Pro Gln Thr Arg Gly His 
    850                 855                 860                 


Asp Trp Arg Met Leu Ala His Lys Leu Asn Leu Asp Arg Tyr Leu Asn 
865                 870                 875                 880 


Tyr Phe Ala Thr Lys Ser Ser Pro Thr Gly Val Ile Leu Asp Leu Trp 
                885                 890                 895     


Glu Ala Gln Asn Phe Pro Asp Gly Asn Leu Ser Met Leu Ala Ala Val 
            900                 905                 910         


Leu Glu Glu Met Gly Arg His Glu Thr Val Val Ser Leu Ala Ala Glu 
        915                 920                 925             


Gly Gln Tyr 
    930     


<210>  2877
<211>  763
<212>  PRT
<213>  Homo sapiens

<400>  2877

Met Asn Gln Lys Thr Ile Leu Val Leu Leu Ile Leu Ala Val Ile Thr 
1               5                   10                  15      


Ile Phe Ala Leu Val Cys Val Leu Leu Val Gly Arg Gly Gly Asp Gly 
            20                  25                  30          


Gly Glu Pro Ser Gln Leu Pro His Cys Pro Ser Val Ser Pro Ser Ala 
        35                  40                  45              


Gln Pro Trp Thr His Pro Gly Gln Ser Gln Leu Phe Ala Asp Leu Ser 
    50                  55                  60                  


Arg Glu Glu Leu Thr Ala Val Met Arg Phe Leu Thr Gln Arg Leu Gly 
65                  70                  75                  80  


Pro Gly Leu Val Asp Ala Ala Gln Ala Arg Pro Ser Asp Asn Cys Val 
                85                  90                  95      


Phe Ser Val Glu Leu Gln Leu Pro Pro Lys Ala Ala Ala Leu Ala His 
            100                 105                 110         


Leu Asp Arg Gly Ser Pro Pro Pro Ala Arg Glu Ala Leu Ala Ile Val 
        115                 120                 125             


Phe Phe Gly Arg Gln Pro Gln Pro Asn Val Ser Glu Leu Val Val Gly 
    130                 135                 140                 


Pro Leu Pro His Pro Ser Tyr Met Arg Asp Val Thr Val Glu Arg His 
145                 150                 155                 160 


Gly Gly Pro Leu Pro Tyr His Arg Arg Pro Val Leu Phe Gln Glu Tyr 
                165                 170                 175     


Leu Asp Ile Asp Gln Met Ile Phe Asn Arg Glu Leu Pro Gln Ala Ser 
            180                 185                 190         


Gly Leu Leu His His Cys Cys Phe Tyr Lys His Arg Gly Arg Asn Leu 
        195                 200                 205             


Val Thr Met Thr Thr Ala Pro Arg Gly Leu Gln Ser Gly Asp Arg Ala 
    210                 215                 220                 


Thr Trp Phe Gly Leu Tyr Tyr Asn Ile Ser Gly Ala Gly Phe Phe Leu 
225                 230                 235                 240 


His His Val Gly Leu Glu Leu Leu Val Asn His Lys Ala Leu Asp Pro 
                245                 250                 255     


Ala Arg Trp Thr Ile Gln Lys Val Phe Tyr Gln Gly Arg Tyr Tyr Asp 
            260                 265                 270         


Ser Leu Ala Gln Leu Glu Ala Gln Phe Glu Ala Gly Leu Val Asn Val 
        275                 280                 285             


Val Leu Ile Pro Asp Asn Gly Thr Gly Gly Ser Trp Ser Leu Lys Ser 
    290                 295                 300                 


Pro Val Pro Pro Gly Pro Ala Pro Pro Leu Gln Phe Tyr Pro Gln Gly 
305                 310                 315                 320 


Pro Arg Phe Ser Val Gln Gly Ser Arg Val Ala Ser Ser Leu Trp Thr 
                325                 330                 335     


Phe Ser Phe Gly Leu Gly Ala Phe Ser Gly Pro Arg Ile Phe Asp Val 
            340                 345                 350         


Arg Phe Gln Gly Glu Arg Leu Val Tyr Glu Ile Ser Leu Gln Glu Ala 
        355                 360                 365             


Leu Ala Ile Tyr Gly Gly Asn Ser Pro Ala Ala Met Thr Thr Arg Tyr 
    370                 375                 380                 


Val Asp Gly Gly Phe Gly Met Gly Lys Tyr Thr Thr Pro Leu Thr Arg 
385                 390                 395                 400 


Gly Val Asp Cys Pro Tyr Leu Ala Thr Tyr Val Asp Trp His Phe Leu 
                405                 410                 415     


Leu Glu Ser Gln Ala Pro Lys Thr Ile Arg Asp Ala Phe Cys Val Phe 
            420                 425                 430         


Glu Gln Asn Gln Gly Leu Pro Leu Arg Arg His His Ser Asp Leu Tyr 
        435                 440                 445             


Ser His Tyr Phe Gly Gly Leu Ala Glu Thr Val Leu Val Val Arg Ser 
    450                 455                 460                 


Met Ser Thr Leu Leu Asn Tyr Asp Tyr Val Trp Asp Thr Val Phe His 
465                 470                 475                 480 


Pro Ser Gly Ala Ile Glu Ile Arg Phe Tyr Ala Thr Gly Tyr Ile Ser 
                485                 490                 495     


Ser Ala Phe Leu Phe Gly Ala Thr Gly Lys Tyr Gly Asn Gln Val Ser 
            500                 505                 510         


Glu His Thr Leu Gly Thr Val His Thr His Ser Ala His Phe Lys Val 
        515                 520                 525             


Asp Leu Asp Val Ala Gly Leu Glu Asn Trp Val Trp Ala Glu Asp Met 
    530                 535                 540                 


Val Phe Val Pro Met Ala Val Pro Trp Ser Pro Glu His Gln Leu Gln 
545                 550                 555                 560 


Arg Leu Gln Val Thr Arg Lys Leu Leu Glu Met Glu Glu Gln Ala Ala 
                565                 570                 575     


Phe Leu Val Gly Ser Ala Thr Pro Arg Tyr Leu Tyr Leu Ala Ser Asn 
            580                 585                 590         


His Ser Asn Lys Trp Gly His Pro Arg Gly Tyr Arg Ile Gln Met Leu 
        595                 600                 605             


Ser Phe Ala Gly Glu Pro Leu Pro Gln Asn Ser Ser Met Ala Arg Gly 
    610                 615                 620                 


Phe Ser Trp Glu Arg Tyr Gln Leu Ala Val Thr Gln Arg Lys Glu Glu 
625                 630                 635                 640 


Glu Pro Ser Ser Ser Ser Val Phe Asn Gln Asn Asp Pro Trp Ala Pro 
                645                 650                 655     


Thr Val Asp Phe Ser Asp Phe Ile Asn Asn Glu Thr Ile Ala Gly Lys 
            660                 665                 670         


Asp Leu Val Ala Trp Val Thr Ala Gly Phe Leu His Ile Pro His Ala 
        675                 680                 685             


Glu Asp Ile Pro Asn Thr Val Thr Val Gly Asn Gly Val Gly Phe Phe 
    690                 695                 700                 


Leu Arg Pro Tyr Asn Phe Phe Asp Glu Asp Pro Ser Phe Tyr Ser Ala 
705                 710                 715                 720 


Asp Ser Ile Tyr Phe Arg Gly Asp Gln Asp Ala Gly Ala Cys Glu Val 
                725                 730                 735     


Asn Pro Leu Ala Cys Leu Pro Gln Ala Ala Ala Cys Ala Pro Asp Leu 
            740                 745                 750         


Pro Ala Phe Ser His Gly Gly Phe Ser His Asn 
        755                 760             


<210>  2878
<211>  934
<212>  PRT
<213>  Homo sapiens

<400>  2878

Met Val Pro Glu Ala Trp Arg Ser Gly Leu Val Ser Thr Gly Arg Val 
1               5                   10                  15      


Val Gly Val Leu Leu Leu Leu Gly Ala Leu Asn Lys Ala Ser Thr Val 
            20                  25                  30          


Ile His Tyr Glu Ile Pro Glu Glu Arg Glu Lys Gly Phe Ala Val Gly 
        35                  40                  45              


Asn Val Val Ala Asn Leu Gly Leu Asp Leu Gly Ser Leu Ser Ala Arg 
    50                  55                  60                  


Arg Phe Arg Val Val Ser Gly Ala Ser Arg Arg Phe Phe Glu Val Asn 
65                  70                  75                  80  


Arg Glu Thr Gly Glu Met Phe Val Asn Asp Arg Leu Asp Arg Glu Glu 
                85                  90                  95      


Leu Cys Gly Thr Leu Pro Ser Cys Thr Val Thr Leu Glu Leu Val Val 
            100                 105                 110         


Glu Asn Pro Leu Glu Leu Phe Ser Val Glu Val Val Ile Gln Asp Ile 
        115                 120                 125             


Asn Asp Asn Asn Pro Ala Phe Pro Thr Gln Glu Met Lys Leu Glu Ile 
    130                 135                 140                 


Ser Glu Ala Val Ala Pro Gly Thr Arg Phe Pro Leu Glu Ser Ala His 
145                 150                 155                 160 


Asp Pro Asp Val Gly Ser Asn Ser Leu Gln Thr Tyr Glu Leu Ser Arg 
                165                 170                 175     


Asn Glu Tyr Phe Ala Leu Arg Val Gln Thr Arg Glu Asp Ser Thr Lys 
            180                 185                 190         


Tyr Ala Glu Leu Val Leu Glu Arg Ala Leu Asp Arg Glu Arg Glu Pro 
        195                 200                 205             


Ser Leu Gln Leu Val Leu Thr Ala Leu Asp Gly Gly Thr Pro Ala Leu 
    210                 215                 220                 


Ser Ala Ser Leu Pro Ile His Ile Lys Val Leu Asp Ala Asn Asp Asn 
225                 230                 235                 240 


Ala Pro Val Phe Asn Gln Ser Leu Tyr Arg Ala Arg Val Leu Glu Asp 
                245                 250                 255     


Ala Pro Ser Gly Thr Arg Val Val Gln Val Leu Ala Thr Asp Leu Asp 
            260                 265                 270         


Glu Gly Pro Asn Gly Glu Ile Ile Tyr Ser Phe Gly Ser His Asn Arg 
        275                 280                 285             


Ala Gly Val Arg Gln Leu Phe Ala Leu Asp Leu Val Thr Gly Met Leu 
    290                 295                 300                 


Thr Ile Lys Gly Arg Leu Asp Phe Glu Asp Thr Lys Leu His Glu Ile 
305                 310                 315                 320 


Tyr Ile Gln Ala Lys Asp Lys Gly Ala Asn Pro Glu Gly Ala His Cys 
                325                 330                 335     


Lys Val Leu Val Glu Val Val Asp Val Asn Asp Asn Ala Pro Glu Ile 
            340                 345                 350         


Thr Val Thr Ser Val Tyr Ser Pro Val Pro Glu Asp Ala Pro Leu Gly 
        355                 360                 365             


Thr Val Ile Ala Leu Leu Ser Val Thr Asp Leu Asp Ala Gly Glu Asn 
    370                 375                 380                 


Gly Leu Val Thr Cys Glu Val Pro Pro Gly Leu Pro Phe Ser Leu Thr 
385                 390                 395                 400 


Ser Ser Leu Lys Asn Tyr Phe Thr Leu Lys Thr Ser Ala Asp Leu Asp 
                405                 410                 415     


Arg Glu Thr Val Pro Glu Tyr Asn Leu Ser Ile Thr Ala Arg Asp Ala 
            420                 425                 430         


Gly Thr Pro Ser Leu Ser Ala Leu Thr Ile Val Arg Val Gln Val Ser 
        435                 440                 445             


Asp Ile Asn Asp Asn Pro Pro Gln Ser Ser Gln Ser Ser Tyr Asp Val 
    450                 455                 460                 


Tyr Ile Glu Glu Asn Asn Leu Pro Gly Ala Pro Ile Leu Asn Leu Ser 
465                 470                 475                 480 


Val Trp Asp Pro Asp Ala Pro Gln Asn Ala Arg Leu Ser Phe Phe Leu 
                485                 490                 495     


Leu Glu Gln Gly Ala Glu Thr Gly Leu Val Gly Arg Tyr Phe Thr Ile 
            500                 505                 510         


Asn Arg Asp Asn Gly Ile Val Ser Ser Leu Val Pro Leu Asp Tyr Glu 
        515                 520                 525             


Asp Arg Arg Glu Phe Glu Leu Thr Ala His Ile Ser Asp Gly Gly Thr 
    530                 535                 540                 


Pro Val Leu Ala Thr Asn Ile Ser Val Asn Ile Phe Val Thr Asp Arg 
545                 550                 555                 560 


Asn Asp Asn Ala Pro Gln Val Leu Tyr Pro Arg Pro Gly Gly Ser Ser 
                565                 570                 575     


Val Glu Met Leu Pro Arg Gly Thr Ser Ala Gly His Leu Val Ser Arg 
            580                 585                 590         


Val Val Gly Trp Asp Ala Asp Ala Gly His Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Ser Leu Leu Gly Ser Pro Asn Gln Ser Leu Phe Ala Ile Gly Leu His 
    610                 615                 620                 


Thr Gly Gln Ile Ser Thr Ala Arg Pro Val Gln Asp Thr Asp Ser Pro 
625                 630                 635                 640 


Arg Gln Thr Leu Thr Val Leu Ile Lys Asp Asn Gly Glu Pro Ser Leu 
                645                 650                 655     


Ser Thr Thr Ala Thr Leu Thr Val Ser Val Thr Glu Asp Ser Pro Glu 
            660                 665                 670         


Ala Arg Ala Glu Phe Pro Ser Gly Ser Ala Pro Arg Glu Gln Lys Lys 
        675                 680                 685             


Asn Leu Thr Phe Tyr Leu Leu Leu Ser Leu Ile Leu Val Ser Val Gly 
    690                 695                 700                 


Phe Val Val Thr Val Phe Gly Val Ile Ile Phe Lys Val Tyr Lys Trp 
705                 710                 715                 720 


Lys Gln Ser Arg Asp Leu Tyr Arg Ala Pro Val Ser Ser Leu Tyr Arg 
                725                 730                 735     


Thr Pro Gly Pro Ser Leu His Ala Asp Ala Val Arg Gly Gly Leu Met 
            740                 745                 750         


Ser Pro His Leu Tyr His Gln Val Tyr Leu Thr Thr Asp Ser Arg Arg 
        755                 760                 765             


Ser Asp Pro Leu Leu Lys Lys Pro Gly Ala Ala Ser Pro Leu Ala Ser 
    770                 775                 780                 


Arg Gln Asn Thr Leu Arg Ser Cys Asp Pro Val Phe Tyr Arg Gln Val 
785                 790                 795                 800 


Leu Gly Ala Glu Ser Ala Pro Pro Gly Gln Gln Ala Pro Pro Asn Thr 
                805                 810                 815     


Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln 
            820                 825                 830         


Asn Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu 
        835                 840                 845             


Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly 
    850                 855                 860                 


Ser Ser Thr Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg 
865                 870                 875                 880 


Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn 
                885                 890                 895     


Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys 
            900                 905                 910         


Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser 
        915                 920                 925             


Gly Lys Lys Glu Lys Lys 
    930                 


<210>  2879
<211>  938
<212>  PRT
<213>  Homo sapiens

<400>  2879

Met Leu Arg Lys Val Arg Ser Trp Thr Glu Ile Trp Arg Trp Ala Thr 
1               5                   10                  15      


Leu Leu Phe Leu Phe Tyr His Leu Gly Tyr Val Cys Gly Gln Ile Arg 
            20                  25                  30          


Tyr Pro Val Pro Glu Glu Ser Gln Glu Gly Thr Phe Val Gly Asn Val 
        35                  40                  45              


Ala Gln Asp Phe Leu Leu Asp Thr Asp Ser Leu Ser Ala Arg Arg Leu 
    50                  55                  60                  


Gln Val Ala Gly Glu Val Asn Gln Arg His Phe Arg Val Asp Leu Asp 
65                  70                  75                  80  


Ser Gly Ala Leu Leu Ile Lys Asn Pro Ile Asp Arg Glu Ala Leu Cys 
                85                  90                  95      


Gly Leu Ser Ala Ser Cys Ile Val Pro Leu Glu Phe Val Thr Glu Gly 
            100                 105                 110         


Pro Leu Glu Met Tyr Arg Ala Glu Val Glu Ile Val Asp Val Asn Asp 
        115                 120                 125             


His Ala Pro Arg Phe Pro Arg Gln Gln Leu Asp Leu Glu Ile Gly Glu 
    130                 135                 140                 


Ala Ala Pro Pro Gly Gln Arg Phe Pro Leu Glu Lys Ala Gln Asp Ala 
145                 150                 155                 160 


Asp Val Gly Ser Asn Ser Ile Ser Ser Tyr Arg Leu Ser Ser Asn Glu 
                165                 170                 175     


His Phe Ala Leu Asp Val Lys Lys Arg Ser Asp Gly Ser Leu Val Pro 
            180                 185                 190         


Glu Leu Leu Leu Glu Lys Pro Leu Asp Arg Glu Lys Gln Ser Asp Tyr 
        195                 200                 205             


Arg Leu Val Leu Thr Ala Val Asp Gly Gly Asn Pro Pro Arg Ser Gly 
    210                 215                 220                 


Thr Ala Glu Leu Arg Val Ser Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Ala Phe Gln Gln Ser Ser Tyr Arg Ile Ser Val Leu Glu Ser Ala Pro 
                245                 250                 255     


Ala Gly Met Val Leu Ile Gln Leu Asn Ala Ser Asp Pro Asp Leu Gly 
            260                 265                 270         


Pro Ser Gly Asn Val Thr Phe Tyr Phe Ser Gly His Thr Pro Asp Arg 
        275                 280                 285             


Val Arg Asn Leu Phe Ser Leu His Pro Thr Thr Gly Lys Leu Thr Leu 
    290                 295                 300                 


Leu Gly Pro Leu Asp Phe Glu Ser Glu Asn Tyr Tyr Glu Phe Asp Val 
305                 310                 315                 320 


Arg Ala Arg Asp Gly Gly Ser Pro Ala Met Glu Gln His Cys Ser Leu 
                325                 330                 335     


Arg Val Asp Leu Leu Asp Val Asn Asp Asn Ala Pro Tyr Ile Thr Val 
            340                 345                 350         


Thr Ser Glu Leu Gly Thr Leu Pro Glu Ser Ala Glu Pro Gly Thr Val 
        355                 360                 365             


Val Ala Leu Ile Ser Val Gln Asp Pro Asp Ser Gly Ser Asn Gly Asp 
    370                 375                 380                 


Val Ser Leu Arg Ile Pro Asp His Leu Pro Phe Ala Leu Lys Ser Ala 
385                 390                 395                 400 


Phe Arg Asn Gln Phe Ser Leu Val Thr Ala Gly Pro Leu Asp Arg Glu 
                405                 410                 415     


Ala Lys Ser Ser Tyr Asp Ile Met Val Thr Ala Ser Asp Ala Gly Asn 
            420                 425                 430         


Pro Pro Leu Ser Thr His Arg Thr Ile Phe Leu Asn Ile Ser Asp Val 
        435                 440                 445             


Asn Asp Asn Pro Pro Ser Phe Phe Gln Arg Ser His Glu Val Phe Val 
    450                 455                 460                 


Pro Glu Asn Asn Arg Pro Gly Asp Leu Leu Cys Ser Leu Ala Ala Ser 
465                 470                 475                 480 


Asp Pro Asp Ser Gly Leu Asn Ala Leu Ile Ser Tyr Ser Leu Leu Glu 
                485                 490                 495     


Pro Arg Asn Arg Asp Val Ser Ala Ser Ser Phe Ile Ser Leu Asn Pro 
            500                 505                 510         


Gln Thr Gly Ala Val His Ala Thr Arg Ser Phe Asp Tyr Glu Gln Thr 
        515                 520                 525             


Gln Thr Leu Gln Phe Glu Val Gln Ala Arg Asp Arg Gly Asn Pro Pro 
    530                 535                 540                 


Leu Ser Ser Thr Val Thr Val Arg Leu Phe Val Leu Asp Leu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Val Leu Arg Pro Arg Ala Arg Pro Gly Ser Leu Cys 
                565                 570                 575     


Pro Gln Ala Leu Pro Pro Ser Val Gly Ala Gly His Leu Ile Thr Lys 
            580                 585                 590         


Val Thr Ala Val Asp Leu Asp Ser Gly Tyr Asn Ala Trp Val Ser Tyr 
        595                 600                 605             


Gln Leu Leu Glu Ala Pro Asp Pro Ser Leu Phe Ala Val Ser Arg Tyr 
    610                 615                 620                 


Ala Gly Glu Val Arg Thr Ala Val Pro Ile Pro Ala Asp Leu Pro Pro 
625                 630                 635                 640 


Gln Lys Leu Val Ile Val Val Lys Asp Ser Gly Ser Pro Pro Leu Ser 
                645                 650                 655     


Thr Ser Val Thr Leu Leu Val Ser Leu Glu Glu Asp Thr His Pro Val 
            660                 665                 670         


Val Pro Asp Leu Arg Glu Ser Ser Ala Pro Arg Glu Gly Glu Ser Arg 
        675                 680                 685             


Leu Thr Leu Tyr Leu Ala Val Ser Leu Val Ala Ile Cys Phe Val Ser 
    690                 695                 700                 


Phe Gly Ser Phe Val Ala Leu Leu Ser Lys Cys Leu Arg Gly Ala Ala 
705                 710                 715                 720 


Cys Gly Val Thr Cys Phe Pro Ala Gly Thr Cys Ala Cys Leu Thr Arg 
                725                 730                 735     


Ser Arg Arg Arg Glu Gly Leu Pro Pro Ser Asn Gly Ile Leu Arg Ile 
            740                 745                 750         


Gln Leu Gly Ser Asp Asp Pro Ile Lys Phe Val Asp Val Gly Gly His 
        755                 760                 765             


Ser His Gly Cys Thr Pro Leu Ala Ser Ala Pro Thr Arg Ser Asp Ser 
    770                 775                 780                 


Phe Met Met Val Lys Ser Pro Ser Ala Pro Met Ala Gly Glu Pro Val 
785                 790                 795                 800 


Arg Pro Ser Cys Pro Pro Ser Asp Leu Leu Tyr Gly Leu Glu Gln Ala 
                805                 810                 815     


Pro Pro Asn Thr Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr 
            820                 825                 830         


Ser Gly Ser Gln Asn Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln 
        835                 840                 845             


Phe Asp Thr Glu Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser Glu 
    850                 855                 860                 


Ala Ala Asp Gly Ser Ser Thr Leu Gly Gly Gly Ala Gly Thr Met Gly 
865                 870                 875                 880 


Leu Ser Ala Arg Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro Asp 
                885                 890                 895     


Tyr Arg Gln Asn Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn 
            900                 905                 910         


Ala Ala Gly Lys Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn 
        915                 920                 925             


Lys Lys Lys Ser Gly Lys Lys Glu Lys Lys 
    930                 935             


<210>  2880
<211>  944
<212>  PRT
<213>  Homo sapiens

<400>  2880

Met Gly Pro Lys Thr Leu Pro Gln Leu Ala Gly Lys Trp Gln Val Leu 
1               5                   10                  15      


Cys Met Leu Ser Leu Cys Cys Trp Gly Trp Val Ser Gly Gln Leu Arg 
            20                  25                  30          


Tyr Ser Val Val Glu Glu Ser Glu Pro Gly Thr Leu Val Gly Asn Val 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Lys Met Thr Asp Leu Leu Ser Arg Arg Leu 
    50                  55                  60                  


Gln Leu Gly Ser Glu Glu Asn Gly Arg Tyr Phe Ser Leu Ser Leu Met 
65                  70                  75                  80  


Ser Gly Ala Leu Ala Val Asn Gln Lys Ile Asp Arg Glu Ser Leu Cys 
                85                  90                  95      


Gly Ala Ser Thr Ser Cys Leu Leu Pro Val Gln Val Val Thr Glu His 
            100                 105                 110         


Pro Leu Glu Leu Ile Arg Val Glu Val Glu Ile Leu Asp Leu Asn Asp 
        115                 120                 125             


Asn Ser Pro Ser Phe Ala Thr Pro Glu Arg Glu Met Arg Ile Ser Glu 
    130                 135                 140                 


Ser Ala Ala Ser Gly Ala Arg Phe Pro Leu Asp Ser Ala Gln Asp Pro 
145                 150                 155                 160 


Asp Val Gly Thr Asn Thr Val Ser Phe Tyr Thr Leu Ser Pro Asn Ser 
                165                 170                 175     


His Phe Ser Leu Asn Val Lys Thr Leu Lys Asp Gly Lys Pro Phe Pro 
            180                 185                 190         


Glu Leu Val Leu Glu Gln Gln Leu Asp Arg Glu Ala Gln Ala Arg His 
        195                 200                 205             


Gln Leu Val Leu Thr Ala Val Asp Gly Gly Thr Pro Ala Arg Ser Gly 
    210                 215                 220                 


Thr Thr Leu Ile Ser Val Ile Val Leu Asp Ile Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Thr Phe Gln Ser Ser Val Leu Arg Val Gly Ile Pro Glu Asn Ala Pro 
                245                 250                 255     


Ile Gly Thr Leu Leu Leu Arg Leu Asn Ala Thr Asp Pro Asp Glu Gly 
            260                 265                 270         


Thr Asn Gly Gln Leu Asp Tyr Ser Phe Gly Asp His Thr Ser Glu Ala 
        275                 280                 285             


Val Arg Asn Leu Phe Gly Leu Asp Pro Ser Ser Gly Ala Ile His Val 
    290                 295                 300                 


Leu Gly Pro Ile Asp Phe Glu Glu Ser Arg Phe Tyr Glu Ile His Ala 
305                 310                 315                 320 


Arg Ala Arg Asp Gln Gly Gln Pro Ala Met Glu Gly His Cys Val Ile 
                325                 330                 335     


Gln Val Asp Val Gly Asp Val Asn Asp Asn Ala Pro Glu Val Leu Leu 
            340                 345                 350         


Ala Ser Leu Ala Asn Pro Val Leu Glu Ser Thr Pro Val Gly Thr Val 
        355                 360                 365             


Val Gly Leu Phe Asn Val Arg Asp Arg Asp Ser Gly Arg Asn Gly Glu 
    370                 375                 380                 


Val Ser Leu Asp Ile Ser Pro Asp Leu Pro Phe Gln Ile Lys Pro Ser 
385                 390                 395                 400 


Glu Asn His Tyr Ser Leu Leu Thr Ser Gln Pro Leu Asp Arg Glu Ala 
                405                 410                 415     


Thr Ser His Tyr Ile Ile Glu Leu Leu Ala Ser Asp Ala Gly Ser Pro 
            420                 425                 430         


Ser Leu His Lys His Leu Thr Ile Arg Leu Asn Ile Ser Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Arg Phe Asn Gln Gln Leu Tyr Thr Ala Tyr Ile Leu 
    450                 455                 460                 


Glu Asn Arg Pro Pro Gly Ser Leu Leu Cys Thr Val Ala Ala Ser Asp 
465                 470                 475                 480 


Pro Asp Thr Gly Asp Asn Ala Arg Leu Thr Tyr Ser Ile Val Gly Asn 
                485                 490                 495     


Gln Val Gln Gly Ala Pro Ala Ser Ser Phe Val Tyr Val Asn Pro Glu 
            500                 505                 510         


Asp Gly Arg Ile Phe Ala Gln Arg Thr Phe Asp Tyr Glu Leu Leu Gln 
        515                 520                 525             


Met Leu Gln Ile Val Val Gly Val Arg Asp Ser Gly Ser Pro Pro Leu 
    530                 535                 540                 


His Ala Asn Thr Ser Leu His Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Val Leu His Pro Arg Pro Asp Trp Glu His Ser Ala Pro 
                565                 570                 575     


Gln Arg Leu Pro Arg Ser Ala Pro Pro Gly Ser Leu Val Thr Lys Val 
            580                 585                 590         


Thr Ala Val Asp Ala Asp Ala Gly His Asn Ala Trp Leu Ser Tyr Ser 
        595                 600                 605             


Leu Leu Pro Gln Ser Thr Ala Pro Gly Leu Phe Leu Val Ser Thr His 
    610                 615                 620                 


Thr Gly Glu Val Arg Thr Ala Arg Ala Leu Leu Glu Asp Asp Ser Asp 
625                 630                 635                 640 


Thr Gln Gln Val Val Val Leu Val Arg Asp Asn Gly Asp Pro Ser Leu 
                645                 650                 655     


Ser Ser Thr Ala Thr Val Leu Leu Val Leu Glu Asp Glu Asp Pro Glu 
            660                 665                 670         


Glu Met Pro Lys Ser Ser Asp Phe Leu Ile His Pro Pro Glu Arg Ser 
        675                 680                 685             


Asp Leu Thr Leu Tyr Leu Ile Val Ala Leu Ala Thr Val Ser Leu Leu 
    690                 695                 700                 


Ser Leu Val Thr Phe Thr Phe Leu Ser Ala Lys Cys Leu Gln Gly Asn 
705                 710                 715                 720 


Ala Asp Gly Asp Gly Gly Gly Gly Gln Cys Cys Arg Arg Gln Asp Ser 
                725                 730                 735     


Pro Ser Pro Asp Phe Tyr Lys Gln Ser Ser Pro Asn Leu Gln Val Ser 
            740                 745                 750         


Ser Asp Gly Thr Leu Lys Tyr Met Glu Val Thr Leu Arg Pro Thr Asp 
        755                 760                 765             


Ser Gln Ser His Cys Tyr Arg Thr Cys Phe Ser Pro Ala Ser Asp Gly 
    770                 775                 780                 


Ser Asp Phe Thr Phe Leu Arg Pro Leu Ser Val Gln Gln Pro Thr Ala 
785                 790                 795                 800 


Leu Ala Leu Glu Pro Asp Ala Ile Arg Ser Arg Ser Asn Thr Leu Arg 
                805                 810                 815     


Glu Arg Ser Gln Gln Ala Pro Pro Asn Thr Asp Trp Arg Phe Ser Gln 
            820                 825                 830         


Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly Asp Asp Thr Gly 
        835                 840                 845             


Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu Gln Ala Met Ile 
    850                 855                 860                 


Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser Thr Leu Gly Gly 
865                 870                 875                 880 


Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly Pro Gln Phe Thr 
                885                 890                 895     


Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr Ile Pro Gly Ser 
            900                 905                 910         


Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp Gly Lys Ala Pro 
        915                 920                 925             


Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys Lys Glu Lys Lys 
    930                 935                 940                 


<210>  2881
<211>  3298
<212>  PRT
<213>  Homo sapiens

<400>  2881

Met Gln Lys Glu Leu Gly Ile Val Pro Ser Cys Pro Gly Met Lys Ser 
1               5                   10                  15      


Pro Arg Pro His Leu Leu Leu Pro Leu Leu Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Gly Ala Gly Val Pro Gly Ala Trp Gly Gln Ala Gly Ser Leu Asp 
        35                  40                  45              


Leu Gln Ile Asp Glu Glu Gln Pro Ala Gly Thr Leu Ile Gly Asp Ile 
    50                  55                  60                  


Ser Ala Gly Leu Pro Ala Gly Thr Ala Ala Pro Leu Met Tyr Phe Ile 
65                  70                  75                  80  


Ser Ala Gln Glu Gly Ser Gly Val Gly Thr Asp Leu Ala Ile Asp Glu 
                85                  90                  95      


His Ser Gly Val Val Arg Thr Ala Arg Val Leu Asp Arg Glu Gln Arg 
            100                 105                 110         


Asp Arg Tyr Arg Phe Thr Ala Val Thr Pro Asp Gly Ala Thr Val Glu 
        115                 120                 125             


Val Thr Val Arg Val Ala Asp Ile Asn Asp His Ala Pro Ala Phe Pro 
    130                 135                 140                 


Gln Ala Arg Ala Ala Leu Gln Val Pro Glu His Thr Ala Phe Gly Thr 
145                 150                 155                 160 


Arg Tyr Pro Leu Glu Pro Ala Arg Asp Ala Asp Ala Gly Arg Leu Gly 
                165                 170                 175     


Thr Gln Gly Tyr Ala Leu Ser Gly Asp Gly Ala Gly Glu Thr Phe Arg 
            180                 185                 190         


Leu Glu Thr Arg Pro Gly Pro Asp Gly Thr Pro Val Pro Glu Leu Val 
        195                 200                 205             


Val Thr Gly Glu Leu Asp Arg Glu Asn Arg Ser His Tyr Met Leu Gln 
    210                 215                 220                 


Leu Glu Ala Tyr Asp Gly Gly Ser Pro Pro Arg Arg Ala Gln Ala Leu 
225                 230                 235                 240 


Leu Asp Val Thr Leu Leu Asp Ile Asn Asp His Ala Pro Ala Phe Asn 
                245                 250                 255     


Gln Ser Arg Tyr His Ala Val Val Ser Glu Ser Leu Ala Pro Gly Ser 
            260                 265                 270         


Pro Val Leu Gln Val Phe Ala Ser Asp Ala Asp Ala Gly Val Asn Gly 
        275                 280                 285             


Ala Val Thr Tyr Glu Ile Asn Arg Arg Gln Ser Glu Gly Asp Gly Pro 
    290                 295                 300                 


Phe Ser Ile Asp Ala His Thr Gly Leu Leu Gln Leu Glu Arg Pro Leu 
305                 310                 315                 320 


Asp Phe Glu Gln Arg Arg Val His Glu Leu Val Val Gln Ala Arg Asp 
                325                 330                 335     


Gly Gly Ala His Pro Glu Leu Gly Ser Ala Phe Val Thr Val His Val 
            340                 345                 350         


Arg Asp Ala Asn Asp Asn Gln Pro Ser Met Thr Val Ile Phe Leu Ser 
        355                 360                 365             


Ala Asp Gly Ser Pro Gln Val Ser Glu Ala Ala Pro Pro Gly Gln Leu 
    370                 375                 380                 


Val Ala Arg Ile Ser Val Ser Asp Pro Asp Asp Gly Asp Phe Ala His 
385                 390                 395                 400 


Val Asn Val Ser Leu Glu Gly Gly Glu Gly His Phe Ala Leu Ser Thr 
                405                 410                 415     


Gln Asp Ser Val Ile Tyr Leu Val Cys Val Ala Arg Arg Leu Asp Arg 
            420                 425                 430         


Glu Glu Arg Asp Ala Tyr Asn Leu Arg Val Thr Ala Thr Asp Ser Gly 
        435                 440                 445             


Ser Pro Pro Leu Arg Ala Glu Ala Ala Phe Val Leu His Val Thr Asp 
    450                 455                 460                 


Val Asn Asp Asn Ala Pro Ala Phe Asp Arg Gln Leu Tyr Arg Pro Glu 
465                 470                 475                 480 


Pro Leu Pro Glu Val Ala Leu Pro Gly Ser Phe Val Val Arg Val Thr 
                485                 490                 495     


Ala Arg Asp Pro Asp Gln Gly Thr Asn Gly Gln Val Thr Tyr Ser Leu 
            500                 505                 510         


Ala Pro Gly Ala His Thr His Trp Phe Ser Ile Asp Pro Thr Ser Gly 
        515                 520                 525             


Ile Ile Thr Thr Ala Ala Ser Leu Asp Tyr Glu Leu Glu Pro Gln Pro 
    530                 535                 540                 


Gln Leu Ile Val Val Ala Thr Asp Gly Gly Leu Pro Pro Leu Ala Ser 
545                 550                 555                 560 


Ser Ala Thr Val Ser Val Ala Leu Gln Asp Val Asn Asp Asn Glu Pro 
                565                 570                 575     


Gln Phe Gln Arg Thr Phe Tyr Asn Ala Ser Leu Pro Glu Gly Thr Gln 
            580                 585                 590         


Pro Gly Thr Cys Phe Leu Gln Val Thr Ala Thr Asp Ala Asp Ser Gly 
        595                 600                 605             


Pro Phe Gly Leu Leu Ser Tyr Ser Leu Gly Ala Gly Leu Gly Ser Ser 
    610                 615                 620                 


Gly Ser Pro Pro Phe Arg Ile Asp Ala His Ser Gly Asp Val Cys Thr 
625                 630                 635                 640 


Thr Arg Thr Leu Asp Arg Asp Gln Gly Pro Ser Ser Phe Asp Phe Thr 
                645                 650                 655     


Val Thr Ala Val Asp Gly Gly Gly Leu Lys Ser Met Val Tyr Val Lys 
            660                 665                 670         


Val Phe Leu Ser Asp Glu Asn Asp Asn Pro Pro Gln Phe Tyr Pro Arg 
        675                 680                 685             


Glu Tyr Ala Ala Ser Ile Ser Ala Gln Ser Pro Pro Gly Thr Ala Val 
    690                 695                 700                 


Leu Arg Leu Arg Ala His Asp Pro Asp Gln Gly Ser His Gly Arg Leu 
705                 710                 715                 720 


Ser Tyr His Ile Leu Ala Gly Asn Ser Pro Pro Leu Phe Thr Leu Asp 
                725                 730                 735     


Glu Gln Ser Gly Leu Leu Thr Val Ala Trp Pro Leu Ala Arg Arg Ala 
            740                 745                 750         


Asn Ser Val Val Gln Leu Glu Ile Gly Ala Glu Asp Gly Gly Gly Leu 
        755                 760                 765             


Gln Ala Glu Pro Ser Ala Arg Val Asp Ile Ser Ile Val Pro Gly Thr 
    770                 775                 780                 


Pro Thr Pro Pro Ile Phe Glu Gln Leu Gln Tyr Val Phe Ser Val Pro 
785                 790                 795                 800 


Glu Asp Val Ala Pro Gly Thr Ser Val Gly Ile Val Gln Ala His Asn 
                805                 810                 815     


Pro Pro Gly Arg Leu Ala Pro Val Thr Leu Ser Leu Ser Gly Gly Asp 
            820                 825                 830         


Pro Arg Gly Leu Phe Ser Leu Asp Ala Val Ser Gly Leu Leu Gln Thr 
        835                 840                 845             


Leu Arg Pro Leu Asp Arg Glu Leu Leu Gly Pro Val Leu Glu Leu Glu 
    850                 855                 860                 


Val Arg Ala Gly Ser Gly Val Pro Pro Ala Phe Ala Val Ala Arg Val 
865                 870                 875                 880 


Arg Val Leu Leu Asp Asp Val Asn Asp Asn Ser Pro Ala Phe Pro Ala 
                885                 890                 895     


Pro Glu Asp Thr Val Leu Leu Pro Pro Asn Thr Ala Pro Gly Thr Pro 
            900                 905                 910         


Ile Tyr Thr Leu Arg Ala Leu Asp Pro Asp Ser Gly Val Asn Ser Arg 
        915                 920                 925             


Val Thr Phe Thr Leu Leu Ala Gly Gly Gly Gly Ala Phe Thr Val Asp 
    930                 935                 940                 


Pro Thr Thr Gly His Val Arg Leu Met Arg Pro Leu Gly Pro Ser Gly 
945                 950                 955                 960 


Gly Pro Ala His Glu Leu Glu Leu Glu Ala Arg Asp Gly Gly Ser Pro 
                965                 970                 975     


Pro Arg Thr Ser His Phe Arg Leu Arg Val Val Val Gln Asp Val Gly 
            980                 985                 990         


Thr Arg Gly Leu Ala Pro Arg Phe  Asn Ser Pro Thr Tyr  Arg Val Asp 
        995                 1000                 1005             


Leu Pro  Ser Gly Thr Thr Ala  Gly Thr Gln Val Leu  Gln Val Gln 
    1010                 1015                 1020             


Ala Gln  Ala Pro Asp Gly Gly  Pro Ile Thr Tyr His  Leu Ala Ala 
    1025                 1030                 1035             


Glu Gly  Ala Ser Ser Pro Phe  Gly Leu Glu Pro Gln  Ser Gly Trp 
    1040                 1045                 1050             


Leu Trp  Val Arg Ala Ala Leu  Asp Arg Glu Ala Gln  Glu Leu Tyr 
    1055                 1060                 1065             


Ile Leu  Lys Val Met Ala Val  Ser Gly Ser Lys Ala  Glu Leu Gly 
    1070                 1075                 1080             


Gln Gln  Thr Gly Thr Ala Thr  Val Arg Val Ser Ile  Leu Asn Gln 
    1085                 1090                 1095             


Asn Glu  His Ser Pro Arg Leu  Ser Glu Asp Pro Thr  Phe Leu Ala 
    1100                 1105                 1110             


Val Ala  Glu Asn Gln Pro Pro  Gly Thr Ser Val Gly  Arg Val Phe 
    1115                 1120                 1125             


Ala Thr  Asp Arg Asp Ser Gly  Pro Asn Gly Arg Leu  Thr Tyr Ser 
    1130                 1135                 1140             


Leu Gln  Gln Leu Ser Glu Asp  Ser Lys Ala Phe Arg  Ile His Pro 
    1145                 1150                 1155             


Gln Thr  Gly Glu Val Thr Thr  Leu Gln Thr Leu Asp  Arg Glu Gln 
    1160                 1165                 1170             


Gln Ser  Ser Tyr Gln Leu Leu  Val Gln Val Gln Asp  Gly Gly Ser 
    1175                 1180                 1185             


Pro Pro  Arg Ser Thr Thr Gly  Thr Val His Val Ala  Val Leu Asp 
    1190                 1195                 1200             


Leu Asn  Asp Asn Ser Pro Thr  Phe Leu Gln Ala Ser  Gly Ala Ala 
    1205                 1210                 1215             


Gly Gly  Gly Leu Pro Ile Gln  Val Pro Asp Arg Val  Pro Pro Gly 
    1220                 1225                 1230             


Thr Leu  Val Thr Thr Leu Gln  Ala Lys Asp Pro Asp  Glu Gly Glu 
    1235                 1240                 1245             


Asn Gly  Thr Ile Leu Tyr Thr  Leu Thr Gly Pro Gly  Ser Glu Leu 
    1250                 1255                 1260             


Phe Ser  Leu His Pro His Ser  Gly Glu Leu Leu Thr  Ala Ala Pro 
    1265                 1270                 1275             


Leu Ile  Arg Ala Glu Arg Pro  His Tyr Val Leu Thr  Leu Ser Ala 
    1280                 1285                 1290             


His Asp  Gln Gly Ser Pro Pro  Arg Ser Ala Ser Leu  Gln Leu Leu 
    1295                 1300                 1305             


Val Gln  Val Leu Pro Ser Ala  Arg Leu Ala Glu Pro  Pro Pro Asp 
    1310                 1315                 1320             


Leu Ala  Glu Arg Asp Pro Ala  Ala Pro Val Pro Val  Val Leu Thr 
    1325                 1330                 1335             


Val Thr  Ala Ala Glu Gly Leu  Arg Pro Gly Ser Leu  Leu Gly Ser 
    1340                 1345                 1350             


Val Ala  Ala Pro Glu Pro Ala  Gly Val Gly Ala Leu  Thr Tyr Thr 
    1355                 1360                 1365             


Leu Val  Gly Gly Ala Asp Pro  Glu Gly Thr Phe Ala  Leu Asp Ala 
    1370                 1375                 1380             


Ala Ser  Gly Arg Leu Tyr Leu  Ala Arg Pro Leu Asp  Phe Glu Ala 
    1385                 1390                 1395             


Gly Pro  Pro Trp Arg Ala Leu  Thr Val Arg Ala Glu  Gly Pro Gly 
    1400                 1405                 1410             


Gly Ala  Gly Ala Arg Leu Leu  Arg Val Gln Val Gln  Val Gln Asp 
    1415                 1420                 1425             


Glu Asn  Glu His Ala Pro Ala  Phe Ala Arg Asp Pro  Leu Ala Leu 
    1430                 1435                 1440             


Ala Leu  Pro Glu Asn Pro Glu  Pro Gly Ala Ala Leu  Tyr Thr Phe 
    1445                 1450                 1455             


Arg Ala  Ser Asp Ala Asp Gly  Pro Gly Pro Asn Ser  Asp Val Arg 
    1460                 1465                 1470             


Tyr Arg  Leu Leu Arg Gln Glu  Pro Pro Val Pro Ala  Leu Arg Leu 
    1475                 1480                 1485             


Asp Ala  Arg Thr Gly Ala Leu  Ser Ala Pro Arg Gly  Leu Asp Arg 
    1490                 1495                 1500             


Glu Thr  Thr Pro Ala Leu Leu  Leu Leu Val Glu Ala  Thr Asp Arg 
    1505                 1510                 1515             


Pro Ala  Asn Ala Ser Arg Arg  Arg Ala Ala Arg Val  Ser Ala Arg 
    1520                 1525                 1530             


Val Phe  Val Thr Asp Glu Asn  Asp Asn Ala Pro Val  Phe Ala Ser 
    1535                 1540                 1545             


Pro Ser  Arg Val Arg Leu Pro  Glu Asp Gln Pro Pro  Gly Pro Ala 
    1550                 1555                 1560             


Ala Leu  His Val Val Ala Arg  Asp Pro Asp Leu Gly  Glu Ala Ala 
    1565                 1570                 1575             


Arg Val  Ser Tyr Arg Leu Ala  Ser Gly Gly Asp Gly  His Phe Arg 
    1580                 1585                 1590             


Leu His  Ser Ser Thr Gly Ala  Leu Ser Val Val Arg  Pro Leu Asp 
    1595                 1600                 1605             


Arg Glu  Gln Arg Ala Glu His  Val Leu Thr Val Val  Ala Ser Asp 
    1610                 1615                 1620             


His Gly  Ser Pro Pro Arg Ser  Ala Thr Gln Val Leu  Thr Val Ser 
    1625                 1630                 1635             


Val Ala  Asp Val Asn Asp Glu  Ala Pro Thr Phe Gln  Gln Gln Glu 
    1640                 1645                 1650             


Tyr Ser  Val Leu Leu Arg Glu  Asn Asn Pro Pro Gly  Thr Ser Leu 
    1655                 1660                 1665             


Leu Thr  Leu Arg Ala Thr Asp  Pro Asp Val Gly Ala  Asn Gly Gln 
    1670                 1675                 1680             


Val Thr  Tyr Gly Gly Val Ser  Ser Glu Ser Phe Ser  Leu Asp Pro 
    1685                 1690                 1695             


Asp Thr  Gly Val Leu Thr Thr  Leu Arg Ala Leu Asp  Arg Glu Glu 
    1700                 1705                 1710             


Gln Glu  Glu Ile Asn Leu Thr  Val Tyr Ala Gln Asp  Arg Gly Ser 
    1715                 1720                 1725             


Pro Pro  Gln Leu Thr His Val  Thr Val Arg Val Ala  Val Glu Asp 
    1730                 1735                 1740             


Glu Asn  Asp His Ala Pro Thr  Phe Gly Ser Ala His  Leu Ser Leu 
    1745                 1750                 1755             


Glu Val  Pro Glu Gly Gln Asp  Pro Gln Thr Leu Thr  Met Leu Arg 
    1760                 1765                 1770             


Ala Ser  Asp Pro Asp Val Gly  Ala Asn Gly Gln Leu  Gln Tyr Arg 
    1775                 1780                 1785             


Ile Leu  Asp Gly Asp Pro Ser  Gly Ala Phe Val Leu  Asp Leu Ala 
    1790                 1795                 1800             


Ser Gly  Glu Phe Gly Thr Met  Arg Pro Leu Asp Arg  Glu Val Glu 
    1805                 1810                 1815             


Pro Ala  Phe Gln Leu Arg Ile  Glu Ala Arg Asp Gly  Gly Gln Pro 
    1820                 1825                 1830             


Ala Leu  Ser Ala Thr Leu Leu  Leu Thr Val Thr Val  Leu Asp Ala 
    1835                 1840                 1845             


Asn Asp  His Ala Pro Ala Phe  Pro Val Pro Ala Tyr  Ser Val Glu 
    1850                 1855                 1860             


Val Pro  Glu Asp Val Pro Ala  Gly Thr Leu Leu Leu  Gln Leu Gln 
    1865                 1870                 1875             


Ala His  Asp Pro Asp Ala Gly  Ala Asn Gly His Val  Thr Tyr Tyr 
    1880                 1885                 1890             


Leu Gly  Ala Gly Thr Ala Gly  Ala Phe Leu Leu Glu  Pro Ser Ser 
    1895                 1900                 1905             


Gly Glu  Leu Arg Thr Ala Ala  Ala Leu Asp Arg Glu  Gln Cys Pro 
    1910                 1915                 1920             


Ser Tyr  Thr Phe Ser Val Ser  Ala Val Asp Gly Ala  Ala Ala Gly 
    1925                 1930                 1935             


Pro Leu  Ser Thr Thr Val Ser  Val Thr Ile Thr Val  Arg Asp Val 
    1940                 1945                 1950             


Asn Asp  His Ala Pro Thr Phe  Pro Thr Ser Pro Leu  Arg Leu Arg 
    1955                 1960                 1965             


Leu Pro  Arg Pro Gly Pro Ser  Phe Ser Thr Pro Thr  Leu Ala Leu 
    1970                 1975                 1980             


Ala Thr  Leu Arg Ala Glu Asp  Arg Asp Ala Gly Ala  Asn Ala Ser 
    1985                 1990                 1995             


Ile Leu  Tyr Arg Leu Ala Gly  Thr Pro Pro Pro Gly  Thr Thr Val 
    2000                 2005                 2010             


Asp Ser  Tyr Thr Gly Glu Ile  Arg Val Ala Arg Ser  Pro Val Ala 
    2015                 2020                 2025             


Leu Gly  Pro Arg Asp Arg Val  Leu Phe Ile Val Ala  Thr Asp Leu 
    2030                 2035                 2040             


Gly Arg  Pro Ala Arg Ser Ala  Thr Gly Val Ile Ile  Val Gly Leu 
    2045                 2050                 2055             


Gln Gly  Glu Ala Glu Arg Gly  Pro Arg Phe Pro Arg  Ala Ser Ser 
    2060                 2065                 2070             


Glu Ala  Thr Ile Arg Glu Asn  Ala Pro Pro Gly Thr  Pro Ile Val 
    2075                 2080                 2085             


Ser Pro  Arg Ala Val His Ala  Gly Gly Thr Asn Gly  Pro Ile Thr 
    2090                 2095                 2100             


Tyr Ser  Ile Leu Ser Gly Asn  Glu Lys Gly Thr Phe  Ser Ile Gln 
    2105                 2110                 2115             


Pro Ser  Thr Gly Ala Ile Thr  Val Arg Ser Ala Glu  Gly Leu Asp 
    2120                 2125                 2130             


Phe Glu  Val Ser Pro Arg Leu  Arg Leu Val Leu Gln  Ala Glu Ser 
    2135                 2140                 2145             


Gly Gly  Ala Phe Ala Phe Thr  Val Leu Thr Leu Thr  Leu Gln Asp 
    2150                 2155                 2160             


Ala Asn  Asp Asn Ala Pro Arg  Phe Leu Arg Pro His  Tyr Val Ala 
    2165                 2170                 2175             


Phe Leu  Pro Glu Ser Arg Pro  Leu Glu Gly Pro Leu  Leu Gln Val 
    2180                 2185                 2190             


Glu Ala  Asp Asp Leu Asp Gln  Gly Ser Gly Gly Gln  Ile Ser Tyr 
    2195                 2200                 2205             


Ser Leu  Ala Ala Ser Gln Pro  Ala Arg Gly Leu Phe  His Val Asp 
    2210                 2215                 2220             


Pro Thr  Thr Gly Thr Ile Thr  Thr Thr Ala Ile Leu  Asp Arg Glu 
    2225                 2230                 2235             


Ile Trp  Ala Glu Thr Arg Leu  Val Leu Met Ala Thr  Asp Arg Gly 
    2240                 2245                 2250             


Ser Pro  Ala Leu Val Gly Ser  Ala Thr Leu Thr Val  Met Val Ile 
    2255                 2260                 2265             


Asp Thr  Asn Asp Asn Arg Pro  Thr Ile Pro Gln Pro  Trp Glu Leu 
    2270                 2275                 2280             


Arg Val  Ser Glu Asp Ala Leu  Leu Gly Ser Glu Ile  Ala Gln Val 
    2285                 2290                 2295             


Thr Gly  Asn Asp Val Asp Ser  Gly Pro Val Leu Trp  Tyr Val Leu 
    2300                 2305                 2310             


Ser Pro  Ser Gly Pro Gln Asp  Pro Phe Ser Val Gly  Arg Tyr Gly 
    2315                 2320                 2325             


Gly Arg  Val Ser Leu Thr Gly  Pro Leu Asp Phe Glu  Gln Cys Asp 
    2330                 2335                 2340             


Arg Tyr  Gln Leu Gln Leu Leu  Ala His Asp Gly Pro  His Glu Gly 
    2345                 2350                 2355             


Arg Ala  Asn Leu Thr Val Leu  Val Glu Asp Val Asn  Asp Asn Ala 
    2360                 2365                 2370             


Pro Ala  Phe Ser Gln Ser Leu  Tyr Gln Val Met Leu  Leu Glu His 
    2375                 2380                 2385             


Thr Pro  Pro Gly Ser Ala Ile  Leu Ser Val Ser Ala  Thr Asp Arg 
    2390                 2395                 2400             


Asp Ser  Gly Ala Asn Gly His  Ile Ser Tyr His Leu  Ala Ser Pro 
    2405                 2410                 2415             


Ala Asp  Gly Phe Ser Val Asp  Pro Asn Asn Gly Thr  Leu Phe Thr 
    2420                 2425                 2430             


Ile Val  Gly Thr Val Ala Leu  Gly His Asp Gly Ser  Gly Ala Val 
    2435                 2440                 2445             


Asp Val  Val Leu Glu Ala Arg  Asp His Gly Ala Pro  Gly Arg Ala 
    2450                 2455                 2460             


Ala Arg  Ala Thr Val His Val  Gln Leu Gln Asp Gln  Asn Asp His 
    2465                 2470                 2475             


Ala Pro  Ser Phe Thr Leu Ser  His Tyr Arg Val Ala  Val Thr Glu 
    2480                 2485                 2490             


Asp Leu  Pro Pro Gly Ser Thr  Leu Leu Thr Leu Glu  Ala Thr Asp 
    2495                 2500                 2505             


Ala Asp  Gly Ser Arg Ser His  Ala Ala Val Asp Tyr  Ser Ile Ile 
    2510                 2515                 2520             


Ser Gly  Asn Trp Gly Arg Val  Phe Gln Leu Glu Pro  Arg Leu Ala 
    2525                 2530                 2535             


Glu Ala  Gly Glu Ser Ala Gly  Pro Gly Pro Arg Ala  Leu Gly Cys 
    2540                 2545                 2550             


Leu Val  Leu Leu Glu Pro Leu  Asp Phe Glu Ser Leu  Thr Gln Tyr 
    2555                 2560                 2565             


Asn Leu  Thr Val Ala Ala Ala  Asp Arg Gly Gln Pro  Pro Gln Ser 
    2570                 2575                 2580             


Ser Val  Val Pro Val Thr Val  Thr Val Leu Asp Val  Asn Asp Asn 
    2585                 2590                 2595             


Pro Pro  Val Phe Thr Arg Ala  Ser Tyr Arg Val Thr  Val Pro Glu 
    2600                 2605                 2610             


Asp Thr  Pro Val Gly Ala Glu  Leu Leu His Val Glu  Ala Ser Asp 
    2615                 2620                 2625             


Ala Asp  Pro Gly Pro His Gly  Leu Val Arg Phe Thr  Val Ser Ser 
    2630                 2635                 2640             


Gly Asp  Pro Ser Gly Leu Phe  Glu Leu Asp Glu Ser  Ser Gly Thr 
    2645                 2650                 2655             


Leu Arg  Leu Ala His Ala Leu  Asp Cys Glu Thr Gln  Ala Arg His 
    2660                 2665                 2670             


Gln Leu  Val Val Gln Ala Ala  Asp Pro Ala Gly Ala  His Phe Ala 
    2675                 2680                 2685             


Leu Ala  Pro Val Thr Ile Glu  Val Gln Asp Val Asn  Asp His Gly 
    2690                 2695                 2700             


Pro Ala  Phe Pro Leu Asn Leu  Leu Ser Thr Ser Val  Ala Glu Asn 
    2705                 2710                 2715             


Gln Pro  Pro Gly Thr Leu Val  Thr Thr Leu His Ala  Ile Asp Gly 
    2720                 2725                 2730             


Asp Ala  Gly Ala Phe Gly Arg  Leu Arg Tyr Ser Leu  Leu Glu Ala 
    2735                 2740                 2745             


Gly Pro  Gly Pro Glu Gly Arg  Glu Ala Phe Ala Leu  Asn Ser Ser 
    2750                 2755                 2760             


Thr Gly  Glu Leu Arg Ala Arg  Val Pro Phe Asp Tyr  Glu His Thr 
    2765                 2770                 2775             


Glu Ser  Phe Arg Leu Leu Val  Gly Ala Ala Asp Ala  Gly Asn Leu 
    2780                 2785                 2790             


Ser Ala  Ser Val Thr Val Ser  Val Leu Val Thr Gly  Glu Asp Glu 
    2795                 2800                 2805             


Tyr Asp  Pro Val Phe Leu Ala  Pro Ala Phe His Phe  Gln Val Pro 
    2810                 2815                 2820             


Glu Gly  Ala Arg Arg Gly His  Ser Leu Gly His Val  Gln Ala Thr 
    2825                 2830                 2835             


Asp Glu  Asp Gly Gly Ala Asp  Gly Leu Val Leu Tyr  Ser Leu Ala 
    2840                 2845                 2850             


Thr Ser  Ser Pro Tyr Phe Gly  Ile Asn Gln Thr Thr  Gly Ala Leu 
    2855                 2860                 2865             


Tyr Leu  Arg Val Asp Ser Arg  Ala Pro Gly Ser Gly  Thr Ala Thr 
    2870                 2875                 2880             


Ser Gly  Gly Gly Gly Arg Thr  Arg Arg Glu Ala Pro  Arg Glu Leu 
    2885                 2890                 2895             


Arg Leu  Glu Val Ile Ala Arg  Gly Pro Leu Pro Gly  Ser Arg Ser 
    2900                 2905                 2910             


Ala Thr  Val Pro Val Thr Val  Asp Ile Thr His Thr  Ala Leu Gly 
    2915                 2920                 2925             


Leu Ala  Pro Asp Leu Asn Leu  Leu Leu Val Gly Ala  Val Ala Ala 
    2930                 2935                 2940             


Ser Leu  Gly Val Val Val Val  Leu Ala Leu Ala Ala  Leu Val Leu 
    2945                 2950                 2955             


Gly Leu  Val Arg Ala Arg Ser  Arg Lys Ala Glu Ala  Ala Pro Gly 
    2960                 2965                 2970             


Pro Met  Ser Gln Ala Ala Pro  Leu Ala Ser Asp Ser  Leu Gln Lys 
    2975                 2980                 2985             


Leu Gly  Arg Glu Pro Pro Ser  Pro Pro Pro Ser Glu  His Leu Tyr 
    2990                 2995                 3000             


His Gln  Thr Leu Pro Ser Tyr  Gly Gly Pro Gly Ala  Gly Gly Pro 
    3005                 3010                 3015             


Tyr Pro  Arg Gly Gly Ser Leu  Asp Pro Ser His Ser  Ser Gly Arg 
    3020                 3025                 3030             


Gly Ser  Ala Glu Ala Ala Glu  Asp Asp Glu Ile Arg  Met Ile Asn 
    3035                 3040                 3045             


Glu Phe  Pro Arg Val Ala Ser  Val Ala Ser Ser Leu  Ala Ala Arg 
    3050                 3055                 3060             


Gly Pro  Asp Ser Gly Ile Gln  Gln Asp Ala Asp Gly  Leu Ser Asp 
    3065                 3070                 3075             


Thr Ser  Cys Glu Pro Pro Ala  Pro Asp Thr Trp Tyr  Lys Gly Arg 
    3080                 3085                 3090             


Lys Ala  Gly Leu Leu Leu Pro  Gly Ala Gly Ala Thr  Leu Tyr Arg 
    3095                 3100                 3105             


Glu Glu  Gly Pro Pro Ala Thr  Ala Thr Ala Phe Leu  Gly Gly Cys 
    3110                 3115                 3120             


Gly Leu  Ser Pro Ala Pro Thr  Gly Asp Tyr Gly Phe  Pro Ala Asp 
    3125                 3130                 3135             


Gly Lys  Pro Cys Val Ala Gly  Ala Leu Thr Ala Ile  Val Ala Gly 
    3140                 3145                 3150             


Glu Glu  Glu Leu Arg Gly Ser  Tyr Asn Trp Asp Tyr  Leu Leu Ser 
    3155                 3160                 3165             


Trp Cys  Pro Gln Phe Gln Pro  Leu Ala Ser Val Phe  Thr Glu Ile 
    3170                 3175                 3180             


Ala Arg  Leu Lys Asp Glu Ala  Arg Pro Cys Pro Pro  Ala Pro Arg 
    3185                 3190                 3195             


Ile Asp  Pro Pro Pro Leu Ile  Thr Ala Val Ala His  Pro Gly Ala 
    3200                 3205                 3210             


Lys Ser  Val Pro Pro Lys Pro  Ala Asn Thr Ala Ala  Ala Arg Ala 
    3215                 3220                 3225             


Ile Phe  Pro Pro Ala Ser His  Arg Ser Pro Ile Ser  His Glu Gly 
    3230                 3235                 3240             


Ser Leu  Ser Ser Ala Ala Met  Ser Pro Ser Phe Ser  Pro Ser Leu 
    3245                 3250                 3255             


Ser Pro  Leu Ala Ala Arg Ser  Pro Val Val Ser Pro  Phe Gly Val 
    3260                 3265                 3270             


Ala Gln  Gly Pro Ser Ala Ser  Ala Leu Ser Ala Glu  Ser Gly Leu 
    3275                 3280                 3285             


Glu Pro  Pro Asp Asp Thr Glu  Leu His Ile 
    3290                 3295             


<210>  2882
<211>  1203
<212>  PRT
<213>  Homo sapiens

<400>  2882

Met Thr Arg Ser Pro Pro Leu Arg Glu Leu Pro Pro Ser Tyr Thr Pro 
1               5                   10                  15      


Pro Ala Arg Thr Ala Ala Pro Gln Ile Leu Ala Gly Ser Leu Lys Ala 
            20                  25                  30          


Pro Leu Trp Leu Arg Ala Tyr Phe Gln Gly Leu Leu Phe Ser Leu Gly 
        35                  40                  45              


Cys Gly Ile Gln Arg His Cys Gly Lys Val Leu Phe Leu Gly Leu Leu 
    50                  55                  60                  


Ala Phe Gly Ala Leu Ala Leu Gly Leu Arg Met Ala Ile Ile Glu Thr 
65                  70                  75                  80  


Asn Leu Glu Gln Leu Trp Val Glu Val Gly Ser Arg Val Ser Gln Glu 
                85                  90                  95      


Leu His Tyr Thr Lys Glu Lys Leu Gly Glu Glu Ala Ala Tyr Thr Ser 
            100                 105                 110         


Gln Met Leu Ile Gln Thr Ala Arg Gln Glu Gly Glu Asn Ile Leu Thr 
        115                 120                 125             


Pro Glu Ala Leu Gly Leu His Leu Gln Ala Ala Leu Thr Ala Ser Lys 
    130                 135                 140                 


Val Gln Val Ser Leu Tyr Gly Lys Ser Trp Asp Leu Asn Lys Ile Cys 
145                 150                 155                 160 


Tyr Lys Ser Gly Val Pro Leu Ile Glu Asn Gly Met Ile Glu Arg Met 
                165                 170                 175     


Ile Glu Lys Leu Phe Pro Cys Val Ile Leu Thr Pro Leu Asp Cys Phe 
            180                 185                 190         


Trp Glu Gly Ala Lys Leu Gln Gly Gly Ser Ala Tyr Leu Pro Gly Arg 
        195                 200                 205             


Pro Asp Ile Gln Trp Thr Asn Leu Asp Pro Glu Gln Leu Leu Glu Glu 
    210                 215                 220                 


Leu Gly Pro Phe Ala Ser Leu Glu Gly Phe Arg Glu Leu Leu Asp Lys 
225                 230                 235                 240 


Ala Gln Val Gly Gln Ala Tyr Val Gly Arg Pro Cys Leu His Pro Asp 
                245                 250                 255     


Asp Leu His Cys Pro Pro Ser Ala Pro Asn His His Ser Arg Gln Ala 
            260                 265                 270         


Pro Asn Val Ala His Glu Leu Ser Gly Gly Cys His Gly Phe Ser His 
        275                 280                 285             


Lys Phe Met His Trp Gln Glu Glu Leu Leu Leu Gly Gly Met Ala Arg 
    290                 295                 300                 


Asp Pro Gln Gly Glu Leu Leu Arg Ala Glu Ala Leu Gln Ser Thr Phe 
305                 310                 315                 320 


Leu Leu Met Ser Pro Arg Gln Leu Tyr Glu His Phe Arg Gly Asp Tyr 
                325                 330                 335     


Gln Thr His Asp Ile Gly Trp Ser Glu Glu Gln Ala Ser Thr Val Leu 
            340                 345                 350         


Gln Ala Trp Gln Arg Arg Phe Val Gln Leu Ala Gln Glu Ala Leu Pro 
        355                 360                 365             


Glu Asn Ala Ser Gln Gln Ile His Ala Phe Ser Ser Thr Thr Leu Asp 
    370                 375                 380                 


Asp Ile Leu His Ala Phe Ser Glu Val Ser Ala Ala Arg Val Val Gly 
385                 390                 395                 400 


Gly Tyr Leu Leu Met Leu Ala Tyr Ala Cys Val Thr Met Leu Arg Trp 
                405                 410                 415     


Asp Cys Ala Gln Ser Gln Gly Ser Val Gly Leu Ala Gly Val Leu Leu 
            420                 425                 430         


Val Ala Leu Ala Val Ala Ser Gly Leu Gly Leu Cys Ala Leu Leu Gly 
        435                 440                 445             


Ile Thr Phe Asn Ala Ala Thr Thr Gln Val Leu Pro Phe Leu Ala Leu 
    450                 455                 460                 


Gly Ile Gly Val Asp Asp Val Phe Leu Leu Ala His Ala Phe Thr Glu 
465                 470                 475                 480 


Ala Leu Pro Gly Thr Pro Leu Gln Glu Arg Met Gly Glu Cys Leu Gln 
                485                 490                 495     


Arg Thr Gly Thr Ser Val Val Leu Thr Ser Ile Asn Asn Met Ala Ala 
            500                 505                 510         


Phe Leu Met Ala Ala Leu Val Pro Ile Pro Ala Leu Arg Ala Phe Ser 
        515                 520                 525             


Leu Gln Ala Ala Ile Val Val Gly Cys Thr Phe Val Ala Val Met Leu 
    530                 535                 540                 


Val Phe Pro Ala Ile Leu Ser Leu Asp Leu Arg Arg Arg His Cys Gln 
545                 550                 555                 560 


Arg Leu Asp Val Leu Cys Cys Phe Ser Ser Pro Cys Ser Ala Gln Val 
                565                 570                 575     


Ile Gln Ile Leu Pro Gln Glu Leu Gly Asp Gly Thr Val Pro Val Gly 
            580                 585                 590         


Ile Ala His Leu Thr Ala Thr Val Gln Ala Phe Thr His Cys Glu Ala 
        595                 600                 605             


Ser Ser Gln His Val Val Thr Ile Leu Pro Pro Gln Ala His Leu Val 
    610                 615                 620                 


Pro Pro Pro Ser Asp Pro Leu Gly Ser Glu Leu Phe Ser Pro Gly Gly 
625                 630                 635                 640 


Ser Thr Arg Asp Leu Leu Gly Gln Glu Glu Glu Thr Arg Gln Lys Ala 
                645                 650                 655     


Ala Cys Lys Ser Leu Pro Cys Ala Arg Trp Asn Leu Ala His Phe Ala 
            660                 665                 670         


Arg Tyr Gln Phe Ala Pro Leu Leu Leu Gln Ser His Ala Lys Ala Ile 
        675                 680                 685             


Val Leu Val Leu Phe Gly Ala Leu Leu Gly Leu Ser Leu Tyr Gly Ala 
    690                 695                 700                 


Thr Leu Val Gln Asp Gly Leu Ala Leu Thr Asp Val Val Pro Arg Gly 
705                 710                 715                 720 


Thr Lys Glu His Ala Phe Leu Ser Ala Gln Leu Arg Tyr Phe Ser Leu 
                725                 730                 735     


Tyr Glu Val Ala Leu Val Thr Gln Gly Gly Phe Asp Tyr Ala His Ser 
            740                 745                 750         


Gln Arg Ala Leu Phe Asp Leu His Gln Arg Phe Ser Ser Leu Lys Ala 
        755                 760                 765             


Val Leu Pro Pro Pro Ala Thr Gln Ala Pro Arg Thr Trp Leu His Tyr 
    770                 775                 780                 


Tyr Arg Asn Trp Leu Gln Gly Ile Gln Ala Ala Phe Asp Gln Asp Trp 
785                 790                 795                 800 


Ala Ser Gly Arg Ile Thr Arg His Ser Tyr Arg Asn Gly Ser Glu Asp 
                805                 810                 815     


Gly Ala Leu Ala Tyr Lys Leu Leu Ile Gln Thr Gly Asp Ala Gln Glu 
            820                 825                 830         


Pro Leu Asp Phe Ser Gln Leu Thr Thr Arg Lys Leu Val Asp Arg Glu 
        835                 840                 845             


Gly Leu Ile Pro Pro Glu Leu Phe Tyr Met Gly Leu Thr Val Trp Val 
    850                 855                 860                 


Ser Ser Asp Pro Leu Gly Leu Ala Ala Ser Gln Ala Asn Phe Tyr Pro 
865                 870                 875                 880 


Pro Pro Pro Glu Trp Leu His Asp Lys Tyr Asp Thr Thr Gly Glu Asn 
                885                 890                 895     


Leu Arg Ile Pro Pro Ala Gln Pro Leu Glu Phe Ala Gln Phe Pro Phe 
            900                 905                 910         


Leu Leu Arg Gly Leu Gln Lys Thr Ala Asp Phe Val Glu Ala Ile Glu 
        915                 920                 925             


Gly Ala Arg Ala Ala Cys Ala Glu Ala Gly Gln Ala Gly Val His Ala 
    930                 935                 940                 


Tyr Pro Ser Gly Ser Pro Phe Leu Phe Trp Glu Gln Tyr Leu Gly Leu 
945                 950                 955                 960 


Arg Arg Cys Phe Leu Leu Ala Val Cys Ile Leu Leu Val Cys Thr Phe 
                965                 970                 975     


Leu Val Cys Ala Leu Leu Leu Leu Asn Pro Trp Thr Ala Gly Leu Ile 
            980                 985                 990         


Val Leu Val Leu Ala Met Met Thr  Val Glu Leu Phe Gly  Ile Met Gly 
        995                 1000                 1005             


Phe Leu  Gly Ile Lys Leu Ser  Ala Ile Pro Val Val  Ile Leu Val 
    1010                 1015                 1020             


Ala Ser  Val Gly Ile Gly Val  Glu Phe Thr Val His  Val Ala Leu 
    1025                 1030                 1035             


Gly Phe  Leu Thr Thr Gln Gly  Ser Arg Asn Leu Arg  Ala Ala His 
    1040                 1045                 1050             


Ala Leu  Glu His Thr Phe Ala  Pro Val Thr Asp Gly  Ala Ile Ser 
    1055                 1060                 1065             


Thr Leu  Leu Gly Leu Leu Met  Leu Ala Gly Ser His  Phe Asp Phe 
    1070                 1075                 1080             


Ile Val  Arg Tyr Phe Phe Ala  Ala Leu Thr Val Leu  Thr Leu Leu 
    1085                 1090                 1095             


Gly Leu  Leu His Gly Leu Val  Leu Leu Pro Val Leu  Leu Ser Ile 
    1100                 1105                 1110             


Leu Gly  Pro Pro Pro Glu Val  Ile Gln Met Tyr Lys  Glu Ser Pro 
    1115                 1120                 1125             


Glu Ile  Leu Ser Pro Pro Ala  Pro Gln Gly Gly Gly  Leu Arg Trp 
    1130                 1135                 1140             


Gly Ala  Ser Ser Ser Leu Pro  Gln Ser Phe Ala Arg  Val Thr Thr 
    1145                 1150                 1155             


Ser Met  Thr Val Ala Ile His  Pro Pro Pro Leu Pro  Gly Ala Tyr 
    1160                 1165                 1170             


Ile His  Pro Ala Pro Asp Glu  Pro Pro Trp Ser Pro  Ala Ala Thr 
    1175                 1180                 1185             


Ser Ser  Gly Asn Leu Ser Ser  Arg Gly Pro Gly Pro  Ala Thr Gly 
    1190                 1195                 1200             


<210>  2883
<211>  499
<212>  PRT
<213>  Homo sapiens

<400>  2883

Met Val Asp Arg Gly Pro Leu Leu Thr Ser Ala Ile Ile Phe Tyr Leu 
1               5                   10                  15      


Ala Ile Gly Ala Ala Ile Phe Glu Val Leu Glu Glu Pro His Trp Lys 
            20                  25                  30          


Glu Ala Lys Lys Asn Tyr Tyr Thr Gln Lys Leu His Leu Leu Lys Glu 
        35                  40                  45              


Phe Pro Cys Leu Gly Gln Glu Gly Leu Asp Lys Ile Leu Glu Val Val 
    50                  55                  60                  


Ser Asp Ala Ala Gly Gln Gly Val Ala Ile Thr Gly Asn Gln Thr Phe 
65                  70                  75                  80  


Asn Asn Trp Asn Trp Pro Asn Ala Met Ile Phe Ala Ala Thr Val Ile 
                85                  90                  95      


Thr Thr Ile Gly Tyr Gly Asn Val Ala Pro Lys Thr Pro Ala Gly Arg 
            100                 105                 110         


Leu Phe Cys Val Phe Tyr Gly Leu Phe Gly Val Pro Leu Cys Leu Thr 
        115                 120                 125             


Trp Ile Ser Ala Leu Gly Lys Phe Phe Gly Gly Arg Ala Lys Arg Leu 
    130                 135                 140                 


Gly Gln Phe Leu Thr Lys Arg Gly Val Ser Leu Arg Lys Ala Gln Ile 
145                 150                 155                 160 


Thr Cys Thr Val Ile Phe Ile Val Trp Gly Val Leu Val His Leu Val 
                165                 170                 175     


Ile Pro Pro Phe Val Phe Met Val Thr Glu Gly Trp Asn Tyr Ile Glu 
            180                 185                 190         


Gly Leu Tyr Tyr Ser Phe Ile Thr Ile Ser Thr Ile Gly Phe Gly Asp 
        195                 200                 205             


Phe Val Ala Gly Val Asn Pro Ser Ala Asn Tyr His Ala Leu Tyr Arg 
    210                 215                 220                 


Tyr Phe Val Glu Leu Trp Ile Tyr Leu Gly Leu Ala Trp Leu Ser Leu 
225                 230                 235                 240 


Phe Val Asn Trp Lys Val Ser Met Phe Val Glu Val His Lys Ala Ile 
                245                 250                 255     


Lys Lys Arg Arg Arg Arg Arg Lys Glu Ser Phe Glu Ser Ser Pro His 
            260                 265                 270         


Ser Arg Lys Ala Leu Gln Val Lys Gly Ser Thr Ala Ser Lys Asp Val 
        275                 280                 285             


Asn Ile Phe Ser Phe Leu Ser Lys Lys Glu Glu Thr Tyr Asn Asp Leu 
    290                 295                 300                 


Ile Lys Gln Ile Gly Lys Lys Ala Met Lys Thr Ser Gly Gly Gly Glu 
305                 310                 315                 320 


Thr Gly Pro Gly Pro Gly Leu Gly Pro Gln Gly Gly Gly Leu Pro Ala 
                325                 330                 335     


Leu Pro Pro Ser Leu Val Pro Leu Val Val Tyr Ser Lys Asn Arg Val 
            340                 345                 350         


Pro Thr Leu Glu Glu Val Ser Gln Thr Leu Arg Ser Lys Gly His Val 
        355                 360                 365             


Ser Arg Ser Pro Asp Glu Glu Ala Val Ala Arg Ala Pro Glu Asp Ser 
    370                 375                 380                 


Ser Pro Ala Pro Glu Val Phe Met Asn Gln Leu Asp Arg Ile Ser Glu 
385                 390                 395                 400 


Glu Cys Glu Pro Trp Asp Ala Gln Asp Tyr His Pro Leu Ile Phe Gln 
                405                 410                 415     


Asp Ala Ser Ile Thr Phe Val Asn Thr Glu Ala Gly Leu Ser Asp Glu 
            420                 425                 430         


Glu Thr Ser Lys Ser Ser Leu Glu Asp Asn Leu Ala Gly Glu Glu Ser 
        435                 440                 445             


Pro Gln Gln Gly Ala Glu Ala Lys Ala Pro Leu Asn Met Gly Glu Phe 
    450                 455                 460                 


Pro Ser Ser Ser Glu Ser Thr Phe Thr Ser Thr Glu Ser Glu Leu Ser 
465                 470                 475                 480 


Val Pro Tyr Glu Gln Leu Met Asn Glu Tyr Asn Lys Ala Asn Ser Pro 
                485                 490                 495     


Lys Gly Thr 
            


<210>  2884
<211>  1321
<212>  PRT
<213>  Homo sapiens

<400>  2884

Met Ser Asp Ser Val Ile Leu Arg Ser Ile Lys Lys Phe Gly Glu Glu 
1               5                   10                  15      


Asn Asp Gly Phe Glu Ser Asp Lys Ser Tyr Asn Asn Asp Lys Lys Ser 
            20                  25                  30          


Arg Leu Gln Asp Glu Lys Lys Gly Asp Gly Val Arg Val Gly Phe Phe 
        35                  40                  45              


Gln Leu Phe Arg Phe Ser Ser Ser Thr Asp Ile Trp Leu Met Phe Val 
    50                  55                  60                  


Gly Ser Leu Cys Ala Phe Leu His Gly Ile Ala Gln Pro Gly Val Leu 
65                  70                  75                  80  


Leu Ile Phe Gly Thr Met Thr Asp Val Phe Ile Asp Tyr Asp Val Glu 
                85                  90                  95      


Leu Gln Glu Leu Gln Ile Pro Gly Lys Ala Cys Val Asn Asn Thr Ile 
            100                 105                 110         


Val Trp Thr Asn Ser Ser Leu Asn Gln Asn Met Thr Asn Gly Thr Arg 
        115                 120                 125             


Cys Gly Leu Leu Asn Ile Glu Ser Glu Met Ile Lys Phe Ala Ser Tyr 
    130                 135                 140                 


Tyr Ala Gly Ile Ala Val Ala Val Leu Ile Thr Gly Tyr Ile Gln Ile 
145                 150                 155                 160 


Cys Phe Trp Val Ile Ala Ala Ala Arg Gln Ile Gln Lys Met Arg Lys 
                165                 170                 175     


Phe Tyr Phe Arg Arg Ile Met Arg Met Glu Ile Gly Trp Phe Asp Cys 
            180                 185                 190         


Asn Ser Val Gly Glu Leu Asn Thr Arg Phe Ser Asp Asp Ile Asn Lys 
        195                 200                 205             


Ile Asn Asp Ala Ile Ala Asp Gln Met Ala Leu Phe Ile Gln Arg Met 
    210                 215                 220                 


Thr Ser Thr Ile Cys Gly Phe Leu Leu Gly Phe Phe Arg Gly Trp Lys 
225                 230                 235                 240 


Leu Thr Leu Val Ile Ile Ser Val Ser Pro Leu Ile Gly Ile Gly Ala 
                245                 250                 255     


Ala Thr Ile Gly Leu Ser Val Ser Lys Phe Thr Asp Tyr Glu Leu Lys 
            260                 265                 270         


Ala Tyr Ala Lys Ala Gly Val Val Ala Asp Glu Val Ile Ser Ser Met 
        275                 280                 285             


Arg Thr Val Ala Ala Phe Gly Gly Glu Lys Arg Glu Val Glu Arg Tyr 
    290                 295                 300                 


Glu Lys Asn Leu Val Phe Ala Gln Arg Trp Gly Ile Arg Lys Gly Ile 
305                 310                 315                 320 


Val Met Gly Phe Phe Thr Gly Phe Val Trp Cys Leu Ile Phe Leu Cys 
                325                 330                 335     


Tyr Ala Leu Ala Phe Trp Tyr Gly Ser Thr Leu Val Leu Asp Glu Gly 
            340                 345                 350         


Glu Tyr Thr Pro Gly Thr Leu Val Gln Ile Phe Leu Ser Val Ile Val 
        355                 360                 365             


Gly Ala Leu Asn Leu Gly Asn Ala Ser Pro Cys Leu Glu Ala Phe Ala 
    370                 375                 380                 


Thr Gly Arg Ala Ala Ala Thr Ser Ile Phe Glu Thr Ile Asp Arg Lys 
385                 390                 395                 400 


Pro Ile Ile Asp Cys Met Ser Glu Asp Gly Tyr Lys Leu Asp Arg Ile 
                405                 410                 415     


Lys Gly Glu Ile Glu Phe His Asn Val Thr Phe His Tyr Pro Ser Arg 
            420                 425                 430         


Pro Glu Val Lys Ile Leu Asn Asp Leu Asn Met Val Ile Lys Pro Gly 
        435                 440                 445             


Glu Met Thr Ala Leu Val Gly Pro Ser Gly Ala Gly Lys Ser Thr Ala 
    450                 455                 460                 


Leu Gln Leu Ile Gln Arg Phe Tyr Asp Pro Cys Glu Gly Met Val Thr 
465                 470                 475                 480 


Val Asp Gly His Asp Ile Arg Ser Leu Asn Ile Gln Trp Leu Arg Asp 
                485                 490                 495     


Gln Ile Gly Ile Val Glu Gln Glu Pro Val Leu Phe Ser Thr Thr Ile 
            500                 505                 510         


Ala Glu Asn Ile Arg Tyr Gly Arg Glu Asp Ala Thr Met Glu Asp Ile 
        515                 520                 525             


Val Gln Ala Ala Lys Glu Ala Asn Ala Tyr Asn Phe Ile Met Asp Leu 
    530                 535                 540                 


Pro Gln Gln Phe Asp Thr Leu Val Gly Glu Gly Gly Gly Gln Met Ser 
545                 550                 555                 560 


Gly Gly Gln Lys Gln Arg Val Ala Ile Ala Arg Ala Leu Ile Arg Asn 
                565                 570                 575     


Pro Lys Ile Leu Leu Leu Asp Met Ala Thr Ser Ala Leu Asp Asn Glu 
            580                 585                 590         


Ser Glu Ala Met Val Gln Glu Val Leu Ser Lys Ile Gln His Gly His 
        595                 600                 605             


Thr Ile Ile Ser Val Ala His Arg Leu Ser Thr Val Arg Ala Ala Asp 
    610                 615                 620                 


Thr Ile Ile Gly Phe Glu His Gly Thr Ala Val Glu Arg Gly Thr His 
625                 630                 635                 640 


Glu Glu Leu Leu Glu Arg Lys Gly Val Tyr Phe Thr Leu Val Thr Leu 
                645                 650                 655     


Gln Ser Gln Gly Asn Gln Ala Leu Asn Glu Glu Asp Ile Lys Asp Ala 
            660                 665                 670         


Thr Glu Asp Asp Met Leu Ala Arg Thr Phe Ser Arg Gly Ser Tyr Gln 
        675                 680                 685             


Asp Ser Leu Arg Ala Ser Ile Arg Gln Arg Ser Lys Ser Gln Leu Ser 
    690                 695                 700                 


Tyr Leu Val His Glu Pro Pro Leu Ala Val Val Asp His Lys Ser Thr 
705                 710                 715                 720 


Tyr Glu Glu Asp Arg Lys Asp Lys Asp Ile Pro Val Gln Glu Glu Val 
                725                 730                 735     


Glu Pro Ala Pro Val Arg Arg Ile Leu Lys Phe Ser Ala Pro Glu Trp 
            740                 745                 750         


Pro Tyr Met Leu Val Gly Ser Val Gly Ala Ala Val Asn Gly Thr Val 
        755                 760                 765             


Thr Pro Leu Tyr Ala Phe Leu Phe Ser Gln Ile Leu Gly Thr Phe Ser 
    770                 775                 780                 


Ile Pro Asp Lys Glu Glu Gln Arg Ser Gln Ile Asn Gly Val Cys Leu 
785                 790                 795                 800 


Leu Phe Val Ala Met Gly Cys Val Ser Leu Phe Thr Gln Phe Leu Gln 
                805                 810                 815     


Gly Tyr Ala Phe Ala Lys Ser Gly Glu Leu Leu Thr Lys Arg Leu Arg 
            820                 825                 830         


Lys Phe Gly Phe Arg Ala Met Leu Gly Gln Asp Ile Ala Trp Phe Asp 
        835                 840                 845             


Asp Leu Arg Asn Ser Pro Gly Ala Leu Thr Thr Arg Leu Ala Thr Asp 
    850                 855                 860                 


Ala Ser Gln Val Gln Gly Ala Ala Gly Ser Gln Ile Gly Met Ile Val 
865                 870                 875                 880 


Asn Ser Phe Thr Asn Val Thr Val Ala Met Ile Ile Ala Phe Ser Phe 
                885                 890                 895     


Ser Trp Lys Leu Ser Leu Val Ile Leu Cys Phe Phe Pro Phe Leu Ala 
            900                 905                 910         


Leu Ser Gly Ala Thr Gln Thr Arg Met Leu Thr Gly Phe Ala Ser Arg 
        915                 920                 925             


Asp Lys Gln Ala Leu Glu Met Val Gly Gln Ile Thr Asn Glu Ala Leu 
    930                 935                 940                 


Ser Asn Ile Arg Thr Val Ala Gly Ile Gly Lys Glu Arg Arg Phe Ile 
945                 950                 955                 960 


Glu Ala Leu Glu Thr Glu Leu Glu Lys Pro Phe Lys Thr Ala Ile Gln 
                965                 970                 975     


Lys Ala Asn Ile Tyr Gly Phe Cys Phe Ala Phe Ala Gln Cys Ile Met 
            980                 985                 990         


Phe Ile Ala Asn Ser Ala Ser Tyr  Arg Tyr Gly Gly Tyr  Leu Ile Ser 
        995                 1000                 1005             


Asn Glu  Gly Leu His Phe Ser  Tyr Val Phe Arg Val  Ile Ser Ala 
    1010                 1015                 1020             


Val Val  Leu Ser Ala Thr Ala  Leu Gly Arg Ala Phe  Ser Tyr Thr 
    1025                 1030                 1035             


Pro Ser  Tyr Ala Lys Ala Lys  Ile Ser Ala Ala Arg  Phe Phe Gln 
    1040                 1045                 1050             


Leu Leu  Asp Arg Gln Pro Pro  Ile Ser Val Tyr Asn  Thr Ala Gly 
    1055                 1060                 1065             


Glu Lys  Trp Asp Asn Phe Gln  Gly Lys Ile Asp Phe  Val Asp Cys 
    1070                 1075                 1080             


Lys Phe  Thr Tyr Pro Ser Arg  Pro Asp Ser Gln Val  Leu Asn Gly 
    1085                 1090                 1095             


Leu Ser  Val Ser Ile Ser Pro  Gly Gln Thr Leu Ala  Phe Val Gly 
    1100                 1105                 1110             


Ser Ser  Gly Cys Gly Lys Ser  Thr Ser Ile Gln Leu  Leu Glu Arg 
    1115                 1120                 1125             


Phe Tyr  Asp Pro Asp Gln Gly  Lys Val Met Ile Asp  Gly His Asp 
    1130                 1135                 1140             


Ser Lys  Lys Val Asn Val Gln  Phe Leu Arg Ser Asn  Ile Gly Ile 
    1145                 1150                 1155             


Val Ser  Gln Glu Pro Val Leu  Phe Ala Cys Ser Ile  Met Asp Asn 
    1160                 1165                 1170             


Ile Lys  Tyr Gly Asp Asn Thr  Lys Glu Ile Pro Met  Glu Arg Val 
    1175                 1180                 1185             


Ile Ala  Ala Ala Lys Gln Ala  Gln Leu His Asp Phe  Val Met Ser 
    1190                 1195                 1200             


Leu Pro  Glu Lys Tyr Glu Thr  Asn Val Gly Ser Gln  Gly Ser Gln 
    1205                 1210                 1215             


Leu Ser  Arg Gly Glu Lys Gln  Arg Ile Ala Ile Ala  Arg Ala Ile 
    1220                 1225                 1230             


Val Arg  Asp Pro Lys Ile Leu  Leu Leu Asp Glu Ala  Thr Ser Ala 
    1235                 1240                 1245             


Leu Asp  Thr Glu Ser Glu Lys  Thr Val Gln Val Ala  Leu Asp Lys 
    1250                 1255                 1260             


Ala Arg  Glu Gly Arg Thr Cys  Ile Val Ile Ala His  Arg Leu Ser 
    1265                 1270                 1275             


Thr Ile  Gln Asn Ala Asp Ile  Ile Ala Val Met Ala  Gln Gly Val 
    1280                 1285                 1290             


Val Ile  Glu Lys Gly Thr His  Glu Glu Leu Met Ala  Gln Lys Gly 
    1295                 1300                 1305             


Ala Tyr  Tyr Lys Leu Val Thr  Thr Gly Ser Pro Ile  Ser 
    1310                 1315                 1320     


<210>  2885
<211>  1035
<212>  PRT
<213>  Homo sapiens

<400>  2885

Met Ser Thr Glu Asn Val Glu Gly Lys Pro Ser Asn Leu Gly Glu Arg 
1               5                   10                  15      


Gly Arg Ala Arg Ser Ser Thr Phe Leu Arg Val Val Gln Pro Met Phe 
            20                  25                  30          


Asn His Ser Ile Phe Thr Ser Ala Val Ser Pro Ala Ala Glu Arg Ile 
        35                  40                  45              


Arg Phe Ile Leu Gly Glu Glu Asp Asp Ser Pro Ala Pro Pro Gln Leu 
    50                  55                  60                  


Phe Thr Glu Leu Asp Glu Leu Leu Ala Val Asp Gly Gln Glu Met Glu 
65                  70                  75                  80  


Trp Lys Glu Thr Ala Arg Trp Ile Lys Phe Glu Glu Lys Val Glu Gln 
                85                  90                  95      


Gly Gly Glu Arg Trp Ser Lys Pro His Val Ala Thr Leu Ser Leu His 
            100                 105                 110         


Ser Leu Phe Glu Leu Arg Thr Cys Met Glu Lys Gly Ser Ile Met Leu 
        115                 120                 125             


Asp Arg Glu Ala Ser Ser Leu Pro Gln Leu Val Glu Met Ile Val Asp 
    130                 135                 140                 


His Gln Ile Glu Thr Gly Leu Leu Lys Pro Glu Leu Lys Asp Lys Val 
145                 150                 155                 160 


Thr Tyr Thr Leu Leu Arg Lys His Arg His Gln Thr Lys Lys Ser Asn 
                165                 170                 175     


Leu Arg Ser Leu Ala Asp Ile Gly Lys Thr Val Ser Ser Ala Ser Arg 
            180                 185                 190         


Met Phe Thr Asn Pro Asp Asn Gly Ser Pro Ala Met Thr His Arg Asn 
        195                 200                 205             


Leu Thr Ser Ser Ser Leu Asn Asp Ile Ser Asp Lys Pro Glu Lys Asp 
    210                 215                 220                 


Gln Leu Lys Asn Lys Phe Met Lys Lys Leu Pro Arg Asp Ala Glu Ala 
225                 230                 235                 240 


Ser Asn Val Leu Val Gly Glu Val Asp Phe Leu Asp Thr Pro Phe Ile 
                245                 250                 255     


Ala Phe Val Arg Leu Gln Gln Ala Val Met Leu Gly Ala Leu Thr Glu 
            260                 265                 270         


Val Pro Val Pro Thr Arg Phe Leu Phe Ile Leu Leu Gly Pro Lys Gly 
        275                 280                 285             


Lys Ala Lys Ser Tyr His Glu Ile Gly Arg Ala Ile Ala Thr Leu Met 
    290                 295                 300                 


Ser Asp Glu Val Phe His Asp Ile Ala Tyr Lys Ala Lys Asp Arg His 
305                 310                 315                 320 


Asp Leu Ile Ala Gly Ile Asp Glu Phe Leu Asp Glu Val Ile Val Leu 
                325                 330                 335     


Pro Pro Gly Glu Trp Asp Pro Ala Ile Arg Ile Glu Pro Pro Lys Ser 
            340                 345                 350         


Leu Pro Ser Ser Asp Lys Arg Lys Asn Met Tyr Ser Gly Gly Glu Asn 
        355                 360                 365             


Val Gln Met Asn Gly Asp Thr Pro His Asp Gly Gly His Gly Gly Gly 
    370                 375                 380                 


Gly His Gly Asp Cys Glu Glu Leu Gln Arg Thr Gly Arg Phe Cys Gly 
385                 390                 395                 400 


Gly Leu Ile Lys Asp Ile Lys Arg Lys Ala Pro Phe Phe Ala Ser Asp 
                405                 410                 415     


Phe Tyr Asp Ala Leu Asn Ile Gln Ala Leu Ser Ala Ile Leu Phe Ile 
            420                 425                 430         


Tyr Leu Ala Thr Val Thr Asn Ala Ile Thr Phe Gly Gly Leu Leu Gly 
        435                 440                 445             


Asp Ala Thr Asp Asn Met Gln Gly Val Leu Glu Ser Phe Leu Gly Thr 
    450                 455                 460                 


Ala Val Ser Gly Ala Ile Phe Cys Leu Phe Ala Gly Gln Pro Leu Thr 
465                 470                 475                 480 


Ile Leu Ser Ser Thr Gly Pro Val Leu Val Phe Glu Arg Leu Leu Phe 
                485                 490                 495     


Asn Phe Ser Lys Asp Asn Asn Phe Asp Tyr Leu Glu Phe Arg Leu Trp 
            500                 505                 510         


Ile Gly Leu Trp Ser Ala Phe Leu Cys Leu Ile Leu Val Ala Thr Asp 
        515                 520                 525             


Ala Ser Phe Leu Val Gln Tyr Phe Thr Arg Phe Thr Glu Glu Gly Phe 
    530                 535                 540                 


Ser Ser Leu Ile Ser Phe Ile Phe Ile Tyr Asp Ala Phe Lys Lys Met 
545                 550                 555                 560 


Ile Lys Leu Ala Asp Tyr Tyr Pro Ile Asn Ser Asn Phe Lys Val Gly 
                565                 570                 575     


Tyr Asn Thr Leu Phe Ser Cys Thr Cys Val Pro Pro Asp Pro Ala Asn 
            580                 585                 590         


Ile Ser Ile Ser Asn Asp Thr Thr Leu Ala Pro Glu Tyr Leu Pro Thr 
        595                 600                 605             


Met Ser Ser Thr Asp Met Tyr His Asn Thr Thr Phe Asp Trp Ala Phe 
    610                 615                 620                 


Leu Ser Lys Lys Glu Cys Ser Lys Tyr Gly Gly Asn Leu Val Gly Asn 
625                 630                 635                 640 


Asn Cys Asn Phe Val Pro Asp Ile Thr Leu Met Ser Phe Ile Leu Phe 
                645                 650                 655     


Leu Gly Thr Tyr Thr Ser Ser Met Ala Leu Lys Lys Phe Lys Thr Ser 
            660                 665                 670         


Pro Tyr Phe Pro Thr Thr Ala Arg Lys Leu Ile Ser Asp Phe Ala Ile 
        675                 680                 685             


Ile Leu Ser Ile Leu Ile Phe Cys Val Ile Asp Ala Leu Val Gly Val 
    690                 695                 700                 


Asp Thr Pro Lys Leu Ile Val Pro Ser Glu Phe Lys Pro Thr Ser Pro 
705                 710                 715                 720 


Asn Arg Gly Trp Phe Val Pro Pro Phe Gly Glu Asn Pro Trp Trp Val 
                725                 730                 735     


Cys Leu Ala Ala Ala Ile Pro Ala Leu Leu Val Thr Ile Leu Ile Phe 
            740                 745                 750         


Met Asp Gln Gln Ile Thr Ala Val Ile Val Asn Arg Lys Glu His Lys 
        755                 760                 765             


Leu Lys Lys Gly Ala Gly Tyr His Leu Asp Leu Phe Trp Val Ala Ile 
    770                 775                 780                 


Leu Met Val Ile Cys Ser Leu Met Ala Leu Pro Trp Tyr Val Ala Ala 
785                 790                 795                 800 


Thr Val Ile Ser Ile Ala His Ile Asp Ser Leu Lys Met Glu Thr Glu 
                805                 810                 815     


Thr Ser Ala Pro Gly Glu Gln Pro Lys Phe Leu Gly Val Arg Glu Gln 
            820                 825                 830         


Arg Val Thr Gly Thr Leu Val Phe Ile Leu Thr Gly Leu Ser Val Phe 
        835                 840                 845             


Met Ala Pro Ile Leu Lys Phe Ile Pro Met Pro Val Leu Tyr Gly Val 
    850                 855                 860                 


Phe Leu Tyr Met Gly Val Ala Ser Leu Asn Gly Val Gln Phe Met Asp 
865                 870                 875                 880 


Arg Leu Lys Leu Leu Leu Met Pro Leu Lys His Gln Pro Asp Phe Ile 
                885                 890                 895     


Tyr Leu Arg His Val Pro Leu Arg Arg Val His Leu Phe Thr Phe Leu 
            900                 905                 910         


Gln Val Leu Cys Leu Ala Leu Leu Trp Ile Leu Lys Ser Thr Val Ala 
        915                 920                 925             


Ala Ile Ile Phe Pro Val Met Ile Leu Ala Leu Val Ala Val Arg Lys 
    930                 935                 940                 


Gly Met Asp Tyr Leu Phe Ser Gln His Asp Leu Ser Phe Leu Asp Asp 
945                 950                 955                 960 


Val Ile Pro Glu Lys Asp Lys Lys Lys Lys Glu Asp Glu Lys Lys Lys 
                965                 970                 975     


Lys Lys Lys Lys Gly Ser Leu Asp Ser Asp Asn Asp Asp Ser Asp Cys 
            980                 985                 990         


Pro Tyr Ser Glu Lys Val Pro Ser  Ile Lys Ile Pro Met  Asp Ile Met 
        995                 1000                 1005             


Glu Gln  Gln Pro Phe Leu Ser  Asp Ser Lys Pro Ser  Asp Arg Glu 
    1010                 1015                 1020             


Arg Ser  Pro Thr Phe Leu Glu  Arg His Thr Ser Cys  
    1025                 1030                 1035 


<210>  2886
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  2886

Met Glu Glu Ala Ser Glu Gly Gly Gly Asn Asp Arg Val Arg Asn Leu 
1               5                   10                  15      


Gln Ser Glu Val Glu Gly Val Lys Asn Ile Met Thr Gln Asn Val Glu 
            20                  25                  30          


Arg Ile Leu Ala Arg Gly Glu Asn Leu Glu His Leu Arg Asn Lys Thr 
        35                  40                  45              


Glu Asp Leu Glu Ala Thr Ser Glu His Phe Lys Thr Thr Ser Gln Lys 
    50                  55                  60                  


Val Ala Arg Lys Phe Trp Trp Lys Asn Val Lys Met Ile Val Leu Ile 
65                  70                  75                  80  


Cys Val Ile Val Phe Ile Ile Ile Leu Phe Ile Val Leu Phe Ala Thr 
                85                  90                  95      


Gly Ala Phe Ser 
            100 


<210>  2887
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  2887

Met Pro Pro Lys Phe Lys Arg His Leu Asn Asp Asp Asp Val Thr Gly 
1               5                   10                  15      


Ser Val Lys Ser Glu Arg Arg Asn Leu Leu Glu Asp Asp Ser Asp Glu 
            20                  25                  30          


Glu Glu Asp Phe Phe Leu Arg Gly Pro Ser Gly Pro Arg Phe Gly Pro 
        35                  40                  45              


Arg Asn Asp Lys Ile Lys His Val Gln Asn Gln Val Asp Glu Val Ile 
    50                  55                  60                  


Asp Val Met Gln Glu Asn Ile Thr Lys Val Ile Glu Arg Gly Glu Arg 
65                  70                  75                  80  


Leu Asp Glu Leu Gln Asp Lys Ser Glu Ser Leu Ser Asp Asn Ala Thr 
                85                  90                  95      


Ala Phe Ser Asn Arg Ser Lys Gln Leu Arg Arg Gln Met Trp Trp Arg 
            100                 105                 110         


Gly Cys Lys Ile Lys Ala Ile Met Ala Leu Val Ala Ala Ile Leu Leu 
        115                 120                 125             


Leu Val Ile Ile Ile Leu Ile Val Met Lys Tyr Arg Thr 
    130                 135                 140     


<210>  2888
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  2888

Met Ser Leu Glu Asp Pro Phe Phe Val Val Arg Gly Glu Val Gln Lys 
1               5                   10                  15      


Ala Val Asn Thr Ala Arg Gly Leu Tyr Gln Arg Trp Cys Glu Leu Leu 
            20                  25                  30          


Gln Glu Ser Ala Ala Val Gly Arg Glu Glu Leu Asp Trp Thr Thr Asn 
        35                  40                  45              


Glu Leu Arg Asn Gly Leu Arg Ser Ile Glu Trp Asp Leu Glu Asp Leu 
    50                  55                  60                  


Glu Glu Thr Ile Gly Ile Val Glu Ala Asn Pro Gly Lys Phe Lys Leu 
65                  70                  75                  80  


Pro Ala Gly Asp Leu Gln Glu Arg Lys Val Phe Val Glu Arg Met Arg 
                85                  90                  95      


Glu Ala Val Gln Glu Met Lys Asp His Met Val Ser Pro Thr Ala Val 
            100                 105                 110         


Ala Phe Leu Glu Arg Asn Asn Arg Glu Ile Leu Ala Gly Lys Pro Ala 
        115                 120                 125             


Ala Gln Lys Ser Pro Ser Asp Leu Leu Asp Ala Ser Ala Val Ser Ala 
    130                 135                 140                 


Thr Ser Arg Tyr Ile Glu Glu Gln Gln Ala Thr Gln Gln Leu Ile Met 
145                 150                 155                 160 


Asp Glu Gln Asp Gln Gln Leu Glu Met Val Ser Gly Ser Ile Gln Val 
                165                 170                 175     


Leu Lys His Met Ser Gly Arg Val Gly Glu Glu Leu Asp Glu Gln Gly 
            180                 185                 190         


Ile Met Leu Asp Ala Phe Ala Gln Glu Met Asp His Thr Gln Ser Arg 
        195                 200                 205             


Met Asp Gly Val Leu Arg Lys Leu Ala Lys Val Ser His Met Thr Ser 
    210                 215                 220                 


Asp Arg Arg Gln Trp Cys Ala Ile Ala Val Leu Val Gly Val Leu Leu 
225                 230                 235                 240 


Leu Val Leu Ile Leu Leu Phe Ser Leu 
                245                 


<210>  2889
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  2889

Met Asn Ala Thr Gly Thr Pro Val Ala Pro Glu Ser Cys Gln Gln Leu 
1               5                   10                  15      


Ala Ala Gly Gly His Ser Arg Leu Ile Val Leu His Tyr Asn His Ser 
            20                  25                  30          


Gly Arg Leu Ala Gly Arg Gly Gly Pro Glu Asp Gly Gly Leu Gly Ala 
        35                  40                  45              


Leu Arg Gly Leu Ser Val Ala Ala Ser Cys Leu Val Val Leu Glu Asn 
    50                  55                  60                  


Leu Leu Val Leu Ala Ala Ile Thr Ser His Met Arg Ser Arg Arg Trp 
65                  70                  75                  80  


Val Tyr Tyr Cys Leu Val Asn Ile Thr Leu Ser Asp Leu Leu Thr Gly 
                85                  90                  95      


Ala Ala Tyr Leu Ala Asn Val Leu Leu Ser Gly Ala Arg Thr Phe Arg 
            100                 105                 110         


Leu Ala Pro Ala Gln Trp Phe Leu Arg Glu Gly Leu Leu Phe Thr Ala 
        115                 120                 125             


Leu Ala Ala Ser Thr Phe Ser Leu Leu Phe Thr Ala Gly Glu Arg Phe 
    130                 135                 140                 


Ala Thr Met Val Arg Pro Val Ala Glu Ser Gly Ala Thr Lys Thr Ser 
145                 150                 155                 160 


Arg Val Tyr Gly Phe Ile Gly Leu Cys Trp Leu Leu Ala Ala Leu Leu 
                165                 170                 175     


Gly Met Leu Pro Leu Leu Gly Trp Asn Cys Leu Cys Ala Phe Asp Arg 
            180                 185                 190         


Cys Ser Ser Leu Leu Pro Leu Tyr Ser Lys Arg Tyr Ile Leu Phe Cys 
        195                 200                 205             


Leu Val Ile Phe Ala Gly Val Leu Ala Thr Ile Met Gly Leu Tyr Gly 
    210                 215                 220                 


Ala Ile Phe Arg Leu Val Gln Ala Ser Gly Gln Lys Ala Pro Arg Pro 
225                 230                 235                 240 


Ala Ala Arg Arg Lys Ala Arg Arg Leu Leu Lys Thr Val Leu Met Ile 
                245                 250                 255     


Leu Leu Ala Phe Leu Val Cys Trp Gly Pro Leu Phe Gly Leu Leu Leu 
            260                 265                 270         


Ala Asp Val Phe Gly Ser Asn Leu Trp Ala Gln Glu Tyr Leu Arg Gly 
        275                 280                 285             


Met Asp Trp Ile Leu Ala Leu Ala Val Leu Asn Ser Ala Val Asn Pro 
    290                 295                 300                 


Ile Ile Tyr Ser Phe Arg Ser Arg Glu Val Cys Arg Ala Val Leu Ser 
305                 310                 315                 320 


Phe Leu Cys Cys Gly Cys Leu Arg Leu Gly Met Arg Gly Pro Gly Asp 
                325                 330                 335     


Cys Leu Ala Arg Ala Val Glu Ala His Ser Gly Ala Ser Thr Thr Asp 
            340                 345                 350         


Ser Ser Leu Arg Pro Arg Asp Ser Phe Arg Gly Ser Arg Ser Leu Ser 
        355                 360                 365             


Phe Arg Met Arg Glu Pro Leu Ser Ser Ile Ser Ser Val Arg Ser Ile 
    370                 375                 380                 


<210>  2890
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  2890

Met Gly Phe Asn Leu Thr Phe His Leu Ser Tyr Lys Phe Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Thr Leu Cys Leu Thr Val Val Gly Trp Ala Thr Ser Asn 
            20                  25                  30          


Tyr Phe Val Gly Ala Ile Gln Glu Ile Pro Lys Ala Lys Glu Phe Met 
        35                  40                  45              


Ala Asn Phe His Lys Thr Leu Ile Leu Gly Lys Gly Lys Thr Leu Thr 
    50                  55                  60                  


Asn Glu Ala Ser Thr Lys Lys Val Glu Leu Asp Asn Cys Pro Ser Val 
65                  70                  75                  80  


Ser Pro Tyr Leu Arg Gly Gln Ser Lys Leu Ile Phe Lys Pro Asp Leu 
                85                  90                  95      


Thr Leu Glu Glu Val Gln Ala Glu Asn Pro Lys Val Ser Arg Gly Arg 
            100                 105                 110         


Tyr Arg Pro Gln Glu Cys Lys Ala Leu Gln Arg Val Ala Ile Leu Val 
        115                 120                 125             


Pro His Arg Asn Arg Glu Lys His Leu Met Tyr Leu Leu Glu His Leu 
    130                 135                 140                 


His Pro Phe Leu Gln Arg Gln Gln Leu Asp Tyr Gly Ile Tyr Val Ile 
145                 150                 155                 160 


His Gln Ala Glu Gly Lys Lys Phe Asn Arg Ala Lys Leu Leu Asn Val 
                165                 170                 175     


Gly Tyr Leu Glu Ala Leu Lys Glu Glu Asn Trp Asp Cys Phe Ile Phe 
            180                 185                 190         


His Asp Val Asp Leu Val Pro Glu Asn Asp Phe Asn Leu Tyr Lys Cys 
        195                 200                 205             


Glu Glu His Pro Lys His Leu Val Val Gly Arg Asn Ser Thr Gly Tyr 
    210                 215                 220                 


Arg Leu Arg Tyr Ser Gly Tyr Phe Gly Gly Val Thr Ala Leu Ser Arg 
225                 230                 235                 240 


Glu Gln Phe Phe Lys Val Asn Gly Phe Ser Asn Asn Tyr Trp Gly Trp 
                245                 250                 255     


Gly Gly Glu Asp Asp Asp Leu Arg Leu Arg Val Glu Leu Gln Arg Met 
            260                 265                 270         


Lys Ile Ser Arg Pro Leu Pro Glu Val Gly Lys Tyr Thr Met Val Phe 
        275                 280                 285             


His Thr Arg Asp Lys Gly Asn Glu Val Asn Ala Glu Arg Met Lys Leu 
    290                 295                 300                 


Leu His Gln Val Ser Arg Val Trp Arg Thr Asp Gly Leu Ser Ser Cys 
305                 310                 315                 320 


Ser Tyr Lys Leu Val Ser Val Glu His Asn Pro Leu Tyr Ile Asn Ile 
                325                 330                 335     


Thr Val Asp Phe Trp Phe Gly Ala 
            340                 


<210>  2891
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  2891

Met Leu Arg Arg Leu Leu Glu Arg Pro Cys Thr Leu Ala Leu Leu Val 
1               5                   10                  15      


Gly Ser Gln Leu Ala Val Met Met Tyr Leu Ser Leu Gly Gly Phe Arg 
            20                  25                  30          


Ser Leu Ser Ala Leu Phe Gly Arg Asp Gln Gly Pro Thr Phe Asp Tyr 
        35                  40                  45              


Ser His Pro Arg Asp Val Tyr Ser Asn Leu Ser His Leu Pro Gly Ala 
    50                  55                  60                  


Pro Gly Gly Pro Pro Ala Pro Gln Gly Leu Pro Tyr Cys Pro Glu Arg 
65                  70                  75                  80  


Ser Pro Leu Leu Val Gly Pro Val Ser Val Ser Phe Ser Pro Val Pro 
                85                  90                  95      


Ser Leu Ala Glu Ile Val Glu Arg Asn Pro Arg Val Glu Pro Gly Gly 
            100                 105                 110         


Arg Tyr Arg Pro Ala Gly Cys Glu Pro Arg Ser Arg Thr Ala Ile Ile 
        115                 120                 125             


Val Pro His Arg Ala Arg Glu His His Leu Arg Leu Leu Leu Tyr His 
    130                 135                 140                 


Leu His Pro Phe Leu Gln Arg Gln Gln Leu Ala Tyr Gly Ile Tyr Val 
145                 150                 155                 160 


Ile His Gln Ala Gly Asn Gly Thr Phe Asn Arg Ala Lys Leu Leu Asn 
                165                 170                 175     


Val Gly Val Arg Glu Ala Leu Arg Asp Glu Glu Trp Asp Cys Leu Phe 
            180                 185                 190         


Leu His Asp Val Asp Leu Leu Pro Glu Asn Asp His Asn Leu Tyr Val 
        195                 200                 205             


Cys Asp Pro Arg Gly Pro Arg His Val Ala Val Ala Met Asn Lys Phe 
    210                 215                 220                 


Gly Tyr Ser Leu Pro Tyr Pro Gln Tyr Phe Gly Gly Val Ser Ala Leu 
225                 230                 235                 240 


Thr Pro Asp Gln Tyr Leu Lys Met Asn Gly Phe Pro Asn Glu Tyr Trp 
                245                 250                 255     


Gly Trp Gly Gly Glu Asp Asp Asp Ile Ala Thr Arg Val Arg Leu Ala 
            260                 265                 270         


Gly Met Lys Ile Ser Arg Pro Pro Thr Ser Val Gly His Tyr Lys Met 
        275                 280                 285             


Val Lys His Arg Gly Asp Lys Gly Asn Glu Glu Asn Pro His Arg Phe 
    290                 295                 300                 


Asp Leu Leu Val Arg Thr Gln Asn Ser Trp Thr Gln Asp Gly Met Asn 
305                 310                 315                 320 


Ser Leu Thr Tyr Gln Leu Leu Ala Arg Glu Leu Gly Pro Leu Tyr Thr 
                325                 330                 335     


Asn Ile Thr Ala Asp Ile Gly Thr Asp Pro Arg Gly Pro Arg Ala Pro 
            340                 345                 350         


Ser Gly Pro Arg Tyr Pro Pro Gly Ser Ser Gln Ala Phe Arg Gln Glu 
        355                 360                 365             


Met Leu Gln Arg Arg Pro Pro Ala Arg Pro Gly Pro Leu Ser Thr Ala 
    370                 375                 380                 


Asn His Thr Ala Leu Arg Gly Ser His 
385                 390             


<210>  2892
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  2892

Met Ala Ser Ala Leu Trp Thr Val Leu Pro Ser Arg Met Ser Leu Arg 
1               5                   10                  15      


Ser Leu Lys Trp Ser Leu Leu Leu Leu Ser Leu Leu Ser Phe Phe Val 
            20                  25                  30          


Met Trp Tyr Leu Ser Leu Pro His Tyr Asn Val Ile Glu Arg Val Asn 
        35                  40                  45              


Trp Met Tyr Phe Tyr Glu Tyr Glu Pro Ile Tyr Arg Gln Asp Phe His 
    50                  55                  60                  


Phe Thr Leu Arg Glu His Ser Asn Cys Ser His Gln Asn Pro Phe Leu 
65                  70                  75                  80  


Val Ile Leu Val Thr Ser His Pro Ser Asp Val Lys Ala Arg Gln Ala 
                85                  90                  95      


Ile Arg Val Thr Trp Gly Glu Lys Lys Ser Trp Trp Gly Tyr Glu Val 
            100                 105                 110         


Leu Thr Phe Phe Leu Leu Gly Gln Glu Ala Glu Lys Glu Asp Lys Met 
        115                 120                 125             


Leu Ala Leu Ser Leu Glu Asp Glu His Leu Leu Tyr Gly Asp Ile Ile 
    130                 135                 140                 


Arg Gln Asp Phe Leu Asp Thr Tyr Asn Asn Leu Thr Leu Lys Thr Ile 
145                 150                 155                 160 


Met Ala Phe Arg Trp Val Thr Glu Phe Cys Pro Asn Ala Lys Tyr Val 
                165                 170                 175     


Met Lys Thr Asp Thr Asp Val Phe Ile Asn Thr Gly Asn Leu Val Lys 
            180                 185                 190         


Tyr Leu Leu Asn Leu Asn His Ser Glu Lys Phe Phe Thr Gly Tyr Pro 
        195                 200                 205             


Leu Ile Asp Asn Tyr Ser Tyr Arg Gly Phe Tyr Gln Lys Thr His Ile 
    210                 215                 220                 


Ser Tyr Gln Glu Tyr Pro Phe Lys Val Phe Pro Pro Tyr Cys Ser Gly 
225                 230                 235                 240 


Leu Gly Tyr Ile Met Ser Arg Asp Leu Val Pro Arg Ile Tyr Glu Met 
                245                 250                 255     


Met Gly His Val Lys Pro Ile Lys Phe Glu Asp Val Tyr Val Gly Ile 
            260                 265                 270         


Cys Leu Asn Leu Leu Lys Val Asn Ile His Ile Pro Glu Asp Thr Asn 
        275                 280                 285             


Leu Phe Phe Leu Tyr Arg Ile His Leu Asp Val Cys Gln Leu Arg Arg 
    290                 295                 300                 


Val Ile Ala Ala His Gly Phe Ser Ser Lys Glu Ile Ile Thr Phe Trp 
305                 310                 315                 320 


Gln Val Met Leu Arg Asn Thr Thr Cys His Tyr 
                325                 330     


<210>  2893
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  2893

Met Gln Leu Arg Leu Phe Arg Arg Leu Leu Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      


Val Ile Val Trp Thr Leu Phe Gly Pro Ser Gly Leu Gly Glu Glu Leu 
            20                  25                  30          


Leu Ser Leu Ser Leu Ala Ser Leu Leu Pro Ala Pro Ala Ser Pro Gly 
        35                  40                  45              


Pro Pro Leu Ala Leu Pro Arg Leu Leu Ile Pro Asn Gln Glu Ala Cys 
    50                  55                  60                  


Ser Gly Pro Gly Ala Pro Pro Phe Leu Leu Ile Leu Val Cys Thr Ala 
65                  70                  75                  80  


Pro Glu Asn Leu Asn Gln Arg Asn Ala Ile Arg Ala Ser Trp Gly Gly 
                85                  90                  95      


Leu Arg Glu Ala Arg Gly Leu Arg Val Gln Thr Leu Phe Leu Leu Gly 
            100                 105                 110         


Glu Pro Asn Ala Gln His Pro Val Trp Gly Ser Gln Gly Ser Asp Leu 
        115                 120                 125             


Ala Ser Glu Ser Ala Ala Gln Gly Asp Ile Leu Gln Ala Ala Phe Gln 
    130                 135                 140                 


Asp Ser Tyr Arg Asn Leu Thr Leu Lys Thr Leu Ser Gly Leu Asn Trp 
145                 150                 155                 160 


Ala Glu Lys His Cys Pro Met Ala Arg Tyr Val Leu Lys Thr Asp Asp 
                165                 170                 175     


Asp Val Tyr Val Asn Val Pro Glu Leu Val Ser Glu Leu Val Leu Arg 
            180                 185                 190         


Gly Gly Arg Trp Gly Gln Trp Glu Arg Ser Thr Glu Pro Gln Arg Glu 
        195                 200                 205             


Ala Glu Gln Glu Gly Gly Gln Val Leu His Ser Glu Glu Val Pro Leu 
    210                 215                 220                 


Leu Tyr Leu Gly Arg Val His Trp Arg Val Asn Pro Ser Arg Thr Pro 
225                 230                 235                 240 


Gly Gly Arg His Arg Val Ser Glu Glu Gln Trp Pro His Thr Trp Gly 
                245                 250                 255     


Pro Phe Pro Pro Tyr Ala Ser Gly Thr Gly Tyr Val Leu Ser Ala Ser 
            260                 265                 270         


Ala Val Gln Leu Ile Leu Lys Val Ala Ser Arg Ala Pro Leu Leu Pro 
        275                 280                 285             


Leu Glu Asp Val Phe Val Gly Val Ser Ala Arg Arg Gly Gly Leu Ala 
    290                 295                 300                 


Pro Thr Gln Cys Val Lys Leu Ala Gly Ala Thr His Tyr Pro Leu Asp 
305                 310                 315                 320 


Arg Cys Cys Tyr Gly Lys Phe Leu Leu Thr Ser His Arg Leu Asp Pro 
                325                 330                 335     


Trp Lys Met Gln Glu Ala Trp Lys Leu Val Gly Gly Ser Asp Gly Glu 
            340                 345                 350         


Arg Thr Ala Pro Phe Cys Ser Trp Phe Gln Gly Val Leu Gly Ile Leu 
        355                 360                 365             


Arg Cys Arg Ala Ile Ala Trp Leu Gln Ser 
    370                 375             


<210>  2894
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  2894

Met Leu Gln Trp Arg Arg Arg His Cys Cys Phe Ala Lys Met Thr Trp 
1               5                   10                  15      


Asn Ala Lys Arg Ser Leu Phe Arg Thr His Leu Ile Gly Val Leu Ser 
            20                  25                  30          


Leu Val Phe Leu Phe Ala Met Phe Leu Phe Phe Asn His His Asp Trp 
        35                  40                  45              


Leu Pro Gly Arg Ala Gly Phe Lys Glu Asn Pro Val Thr Tyr Thr Phe 
    50                  55                  60                  


Arg Gly Phe Arg Ser Thr Lys Ser Glu Thr Asn His Ser Ser Leu Arg 
65                  70                  75                  80  


Asn Ile Trp Lys Glu Thr Val Pro Gln Thr Leu Arg Pro Gln Thr Ala 
                85                  90                  95      


Thr Asn Ser Asn Asn Thr Asp Leu Ser Pro Gln Gly Val Thr Gly Leu 
            100                 105                 110         


Glu Asn Thr Leu Ser Ala Asn Gly Ser Ile Tyr Asn Glu Lys Gly Thr 
        115                 120                 125             


Gly His Pro Asn Ser Tyr His Phe Lys Tyr Ile Ile Asn Glu Pro Glu 
    130                 135                 140                 


Lys Cys Gln Glu Lys Ser Pro Phe Leu Ile Leu Leu Ile Ala Ala Glu 
145                 150                 155                 160 


Pro Gly Gln Ile Glu Ala Arg Arg Ala Ile Arg Gln Thr Trp Gly Asn 
                165                 170                 175     


Glu Ser Leu Ala Pro Gly Ile Gln Ile Thr Arg Ile Phe Leu Leu Gly 
            180                 185                 190         


Leu Ser Ile Lys Leu Asn Gly Tyr Leu Gln Arg Ala Ile Leu Glu Glu 
        195                 200                 205             


Ser Arg Gln Tyr His Asp Ile Ile Gln Gln Glu Tyr Leu Asp Thr Tyr 
    210                 215                 220                 


Tyr Asn Leu Thr Ile Lys Thr Leu Met Gly Met Asn Trp Val Ala Thr 
225                 230                 235                 240 


Tyr Cys Pro His Ile Pro Tyr Val Met Lys Thr Asp Ser Asp Met Phe 
                245                 250                 255     


Val Asn Thr Glu Tyr Leu Ile Asn Lys Leu Leu Lys Pro Asp Leu Pro 
            260                 265                 270         


Pro Arg His Asn Tyr Phe Thr Gly Tyr Leu Met Arg Gly Tyr Ala Pro 
        275                 280                 285             


Asn Arg Asn Lys Asp Ser Lys Trp Tyr Met Pro Pro Asp Leu Tyr Pro 
    290                 295                 300                 


Ser Glu Arg Tyr Pro Val Phe Cys Ser Gly Thr Gly Tyr Val Phe Ser 
305                 310                 315                 320 


Gly Asp Leu Ala Glu Lys Ile Phe Lys Val Ser Leu Gly Ile Arg Arg 
                325                 330                 335     


Leu His Leu Glu Asp Val Tyr Val Gly Ile Cys Leu Ala Lys Leu Arg 
            340                 345                 350         


Ile Asp Pro Val Pro Pro Pro Asn Glu Phe Val Phe Asn His Trp Arg 
        355                 360                 365             


Val Ser Tyr Ser Ser Cys Lys Tyr Ser His Leu Ile Thr Ser His Gln 
    370                 375                 380                 


Phe Gln Pro Ser Glu Leu Ile Lys Tyr Trp Asn His Leu Gln Gln Asn 
385                 390                 395                 400 


Lys His Asn Ala Cys Ala Asn Ala Ala Lys Glu Lys Ala Gly Arg Tyr 
                405                 410                 415     


Arg His Arg Lys Leu His 
            420         


<210>  2895
<211>  1527
<212>  PRT
<213>  Homo sapiens

<400>  2895

Met Asp Ala Leu Cys Gly Ser Gly Glu Leu Gly Ser Lys Phe Trp Asp 
1               5                   10                  15      


Ser Asn Leu Ser Val His Thr Glu Asn Pro Asp Leu Thr Pro Cys Phe 
            20                  25                  30          


Gln Asn Ser Leu Leu Ala Trp Val Pro Cys Ile Tyr Leu Trp Val Ala 
        35                  40                  45              


Leu Pro Cys Tyr Leu Leu Tyr Leu Arg His His Cys Arg Gly Tyr Ile 
    50                  55                  60                  


Ile Leu Ser His Leu Ser Lys Leu Lys Met Val Leu Gly Val Leu Leu 
65                  70                  75                  80  


Trp Cys Val Ser Trp Ala Asp Leu Phe Tyr Ser Phe His Gly Leu Val 
                85                  90                  95      


His Gly Arg Ala Pro Ala Pro Val Phe Phe Val Thr Pro Leu Val Val 
            100                 105                 110         


Gly Val Thr Met Leu Leu Ala Thr Leu Leu Ile Gln Tyr Glu Arg Leu 
        115                 120                 125             


Gln Gly Val Gln Ser Ser Gly Val Leu Ile Ile Phe Trp Phe Leu Cys 
    130                 135                 140                 


Val Val Cys Ala Ile Val Pro Phe Arg Ser Lys Ile Leu Leu Ala Lys 
145                 150                 155                 160 


Ala Glu Gly Glu Ile Ser Asp Pro Phe Arg Phe Thr Thr Phe Tyr Ile 
                165                 170                 175     


His Phe Ala Leu Val Leu Ser Ala Leu Ile Leu Ala Cys Phe Arg Glu 
            180                 185                 190         


Lys Pro Pro Phe Phe Ser Ala Lys Asn Val Asp Pro Asn Pro Tyr Pro 
        195                 200                 205             


Glu Thr Ser Ala Gly Phe Leu Ser Arg Leu Phe Phe Trp Trp Phe Thr 
    210                 215                 220                 


Lys Met Ala Ile Tyr Gly Tyr Arg His Pro Leu Glu Glu Lys Asp Leu 
225                 230                 235                 240 


Trp Ser Leu Lys Glu Glu Asp Arg Ser Gln Met Val Val Gln Gln Leu 
                245                 250                 255     


Leu Glu Ala Trp Arg Lys Gln Glu Lys Gln Thr Ala Arg His Lys Ala 
            260                 265                 270         


Ser Ala Ala Pro Gly Lys Asn Ala Ser Gly Glu Asp Glu Val Leu Leu 
        275                 280                 285             


Gly Ala Arg Pro Arg Pro Arg Lys Pro Ser Phe Leu Lys Ala Leu Leu 
    290                 295                 300                 


Ala Thr Phe Gly Ser Ser Phe Leu Ile Ser Ala Cys Phe Lys Leu Ile 
305                 310                 315                 320 


Gln Asp Leu Leu Ser Phe Ile Asn Pro Gln Leu Leu Ser Ile Leu Ile 
                325                 330                 335     


Arg Phe Ile Ser Asn Pro Met Ala Pro Ser Trp Trp Gly Phe Leu Val 
            340                 345                 350         


Ala Gly Leu Met Phe Leu Cys Ser Met Met Gln Ser Leu Ile Leu Gln 
        355                 360                 365             


His Tyr Tyr His Tyr Ile Phe Val Thr Gly Val Lys Phe Arg Thr Gly 
    370                 375                 380                 


Ile Met Gly Val Ile Tyr Arg Lys Ala Leu Val Ile Thr Asn Ser Val 
385                 390                 395                 400 


Lys Arg Ala Ser Thr Val Gly Glu Ile Val Asn Leu Met Ser Val Asp 
                405                 410                 415     


Ala Gln Arg Phe Met Asp Leu Ala Pro Phe Leu Asn Leu Leu Trp Ser 
            420                 425                 430         


Ala Pro Leu Gln Ile Ile Leu Ala Ile Tyr Phe Leu Trp Gln Asn Leu 
        435                 440                 445             


Gly Pro Ser Val Leu Ala Gly Val Ala Phe Met Val Leu Leu Ile Pro 
    450                 455                 460                 


Leu Asn Gly Ala Val Ala Val Lys Met Arg Ala Phe Gln Val Lys Gln 
465                 470                 475                 480 


Met Lys Leu Lys Asp Ser Arg Ile Lys Leu Met Ser Glu Ile Leu Asn 
                485                 490                 495     


Gly Ile Lys Val Leu Lys Leu Tyr Ala Trp Glu Pro Ser Phe Leu Lys 
            500                 505                 510         


Gln Val Glu Gly Ile Arg Gln Gly Glu Leu Gln Leu Leu Arg Thr Ala 
        515                 520                 525             


Ala Tyr Leu His Thr Thr Thr Thr Phe Thr Trp Met Cys Ser Pro Phe 
    530                 535                 540                 


Leu Val Thr Leu Ile Thr Leu Trp Val Tyr Val Tyr Val Asp Pro Asn 
545                 550                 555                 560 


Asn Val Leu Asp Ala Glu Lys Ala Phe Val Ser Val Ser Leu Phe Asn 
                565                 570                 575     


Ile Leu Arg Leu Pro Leu Asn Met Leu Pro Gln Leu Ile Ser Asn Leu 
            580                 585                 590         


Thr Gln Ala Ser Val Ser Leu Lys Arg Ile Gln Gln Phe Leu Ser Gln 
        595                 600                 605             


Glu Glu Leu Asp Pro Gln Ser Val Glu Arg Lys Thr Ile Ser Pro Gly 
    610                 615                 620                 


Tyr Ala Ile Thr Ile His Ser Gly Thr Phe Thr Trp Ala Gln Asp Leu 
625                 630                 635                 640 


Pro Pro Thr Leu His Ser Leu Asp Ile Gln Val Pro Lys Gly Ala Leu 
                645                 650                 655     


Val Ala Val Val Gly Pro Val Gly Cys Gly Lys Ser Ser Leu Val Ser 
            660                 665                 670         


Ala Leu Leu Gly Glu Met Glu Lys Leu Glu Gly Lys Val His Met Lys 
        675                 680                 685             


Gly Ser Val Ala Tyr Val Pro Gln Gln Ala Trp Ile Gln Asn Cys Thr 
    690                 695                 700                 


Leu Gln Glu Asn Val Leu Phe Gly Lys Ala Leu Asn Pro Lys Arg Tyr 
705                 710                 715                 720 


Gln Gln Thr Leu Glu Ala Cys Ala Leu Leu Ala Asp Leu Glu Met Leu 
                725                 730                 735     


Pro Gly Gly Asp Gln Thr Glu Ile Gly Glu Lys Gly Ile Asn Leu Ser 
            740                 745                 750         


Gly Gly Gln Arg Gln Arg Val Ser Leu Ala Arg Ala Val Tyr Ser Asp 
        755                 760                 765             


Ala Asp Ile Phe Leu Leu Asp Asp Pro Leu Ser Ala Val Asp Ser His 
    770                 775                 780                 


Val Ala Lys His Ile Phe Asp His Val Ile Gly Pro Glu Gly Val Leu 
785                 790                 795                 800 


Ala Gly Lys Thr Arg Val Leu Val Thr His Gly Ile Ser Phe Leu Pro 
                805                 810                 815     


Gln Thr Asp Phe Ile Ile Val Leu Ala Asp Gly Gln Val Ser Glu Met 
            820                 825                 830         


Gly Pro Tyr Pro Ala Leu Leu Gln Arg Asn Gly Ser Phe Ala Asn Phe 
        835                 840                 845             


Leu Cys Asn Tyr Ala Pro Asp Glu Asp Gln Gly His Leu Glu Asp Ser 
    850                 855                 860                 


Trp Thr Ala Leu Glu Gly Ala Glu Asp Lys Glu Ala Leu Leu Ile Glu 
865                 870                 875                 880 


Asp Thr Leu Ser Asn His Thr Asp Leu Thr Asp Asn Asp Pro Val Thr 
                885                 890                 895     


Tyr Val Val Gln Lys Gln Phe Met Arg Gln Leu Ser Ala Leu Ser Ser 
            900                 905                 910         


Asp Gly Glu Gly Gln Gly Arg Pro Val Pro Arg Arg His Leu Gly Pro 
        915                 920                 925             


Ser Glu Lys Val Gln Val Thr Glu Ala Lys Ala Asp Gly Ala Leu Thr 
    930                 935                 940                 


Gln Glu Glu Lys Ala Ala Ile Gly Thr Val Glu Leu Ser Val Phe Trp 
945                 950                 955                 960 


Asp Tyr Ala Lys Ala Val Gly Leu Cys Thr Thr Leu Ala Ile Cys Leu 
                965                 970                 975     


Leu Tyr Val Gly Gln Ser Ala Ala Ala Ile Gly Ala Asn Val Trp Leu 
            980                 985                 990         


Ser Ala Trp Thr Asn Asp Ala Met  Ala Asp Ser Arg Gln  Asn Asn Thr 
        995                 1000                 1005             


Ser Leu  Arg Leu Gly Val Tyr  Ala Ala Leu Gly Ile  Leu Gln Gly 
    1010                 1015                 1020             


Phe Leu  Val Met Leu Ala Ala  Met Ala Met Ala Ala  Gly Gly Ile 
    1025                 1030                 1035             


Gln Ala  Ala Arg Val Leu His  Gln Ala Leu Leu His  Asn Lys Ile 
    1040                 1045                 1050             


Arg Ser  Pro Gln Ser Phe Phe  Asp Thr Thr Pro Ser  Gly Arg Ile 
    1055                 1060                 1065             


Leu Asn  Cys Phe Ser Lys Asp  Ile Tyr Val Val Asp  Glu Val Leu 
    1070                 1075                 1080             


Ala Pro  Val Ile Leu Met Leu  Leu Asn Ser Phe Phe  Asn Ala Ile 
    1085                 1090                 1095             


Ser Thr  Leu Val Val Ile Met  Ala Ser Thr Pro Leu  Phe Thr Val 
    1100                 1105                 1110             


Val Ile  Leu Pro Leu Ala Val  Leu Tyr Thr Leu Val  Gln Arg Phe 
    1115                 1120                 1125             


Tyr Ala  Ala Thr Ser Arg Gln  Leu Lys Arg Leu Glu  Ser Val Ser 
    1130                 1135                 1140             


Arg Ser  Pro Ile Tyr Ser His  Phe Ser Glu Thr Val  Thr Gly Ala 
    1145                 1150                 1155             


Ser Val  Ile Arg Ala Tyr Asn  Arg Ser Arg Asp Phe  Glu Ile Ile 
    1160                 1165                 1170             


Ser Asp  Thr Lys Val Asp Ala  Asn Gln Arg Ser Cys  Tyr Pro Tyr 
    1175                 1180                 1185             


Ile Ile  Ser Asn Arg Trp Leu  Ser Ile Gly Val Glu  Phe Val Gly 
    1190                 1195                 1200             


Asn Cys  Val Val Leu Phe Ala  Ala Leu Phe Ala Val  Ile Gly Arg 
    1205                 1210                 1215             


Ser Ser  Leu Asn Pro Gly Leu  Val Gly Leu Ser Val  Ser Tyr Ser 
    1220                 1225                 1230             


Leu Gln  Val Thr Phe Ala Leu  Asn Trp Met Ile Arg  Met Met Ser 
    1235                 1240                 1245             


Asp Leu  Glu Ser Asn Ile Val  Ala Val Glu Arg Val  Lys Glu Tyr 
    1250                 1255                 1260             


Ser Lys  Thr Glu Thr Glu Ala  Pro Trp Val Val Glu  Gly Ser Arg 
    1265                 1270                 1275             


Pro Pro  Glu Gly Trp Pro Pro  Arg Gly Glu Val Glu  Phe Arg Asn 
    1280                 1285                 1290             


Tyr Ser  Val Arg Tyr Arg Pro  Gly Leu Asp Leu Val  Leu Arg Asp 
    1295                 1300                 1305             


Leu Ser  Leu His Val His Gly  Gly Glu Lys Val Gly  Ile Val Gly 
    1310                 1315                 1320             


Arg Thr  Gly Ala Gly Lys Ser  Ser Met Thr Leu Cys  Leu Phe Arg 
    1325                 1330                 1335             


Ile Leu  Glu Ala Ala Lys Gly  Glu Ile Arg Ile Asp  Gly Leu Asn 
    1340                 1345                 1350             


Val Ala  Asp Ile Gly Leu His  Asp Leu Arg Ser Gln  Leu Thr Ile 
    1355                 1360                 1365             


Ile Pro  Gln Asp Pro Ile Leu  Phe Ser Gly Thr Leu  Arg Met Asn 
    1370                 1375                 1380             


Leu Asp  Pro Phe Gly Ser Tyr  Ser Glu Glu Asp Ile  Trp Trp Ala 
    1385                 1390                 1395             


Leu Glu  Leu Ser His Leu His  Thr Phe Val Ser Ser  Gln Pro Ala 
    1400                 1405                 1410             


Gly Leu  Asp Phe Gln Cys Ser  Glu Gly Gly Glu Asn  Leu Ser Val 
    1415                 1420                 1425             


Gly Gln  Arg Gln Leu Val Cys  Leu Ala Arg Ala Leu  Leu Arg Lys 
    1430                 1435                 1440             


Ser Arg  Ile Leu Val Leu Asp  Glu Ala Thr Ala Ala  Ile Asp Leu 
    1445                 1450                 1455             


Glu Thr  Asp Asn Leu Ile Gln  Ala Thr Ile Arg Thr  Gln Phe Asp 
    1460                 1465                 1470             


Thr Cys  Thr Val Leu Thr Ile  Ala His Arg Leu Asn  Thr Ile Met 
    1475                 1480                 1485             


Asp Tyr  Thr Arg Val Leu Val  Leu Asp Lys Gly Val  Val Ala Glu 
    1490                 1495                 1500             


Phe Asp  Ser Pro Ala Asn Leu  Ile Ala Ala Arg Gly  Ile Phe Tyr 
    1505                 1510                 1515             


Gly Met  Ala Arg Asp Ala Gly  Leu Ala 
    1520                 1525         


<210>  2896
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  2896

Met Glu Gln Arg Pro Arg Gly Cys Ala Ala Val Ala Ala Ala Leu Leu 
1               5                   10                  15      


Leu Val Leu Leu Gly Ala Arg Ala Gln Gly Gly Thr Arg Ser Pro Arg 
            20                  25                  30          


Cys Asp Cys Ala Gly Asp Phe His Lys Lys Ile Gly Leu Phe Cys Cys 
        35                  40                  45              


Arg Gly Cys Pro Ala Gly His Tyr Leu Lys Ala Pro Cys Thr Glu Pro 
    50                  55                  60                  


Cys Gly Asn Ser Thr Cys Leu Val Cys Pro Gln Asp Thr Phe Leu Ala 
65                  70                  75                  80  


Trp Glu Asn His His Asn Ser Glu Cys Ala Arg Cys Gln Ala Cys Asp 
                85                  90                  95      


Glu Gln Ala Ser Gln Val Ala Leu Glu Asn Cys Ser Ala Val Ala Asp 
            100                 105                 110         


Thr Arg Cys Gly Cys Lys Pro Gly Trp Phe Val Glu Cys Gln Val Ser 
        115                 120                 125             


Gln Cys Val Ser Ser Ser Pro Phe Tyr Cys Gln Pro Cys Leu Asp Cys 
    130                 135                 140                 


Gly Ala Leu His Arg His Thr Arg Leu Leu Cys Ser Arg Arg Asp Thr 
145                 150                 155                 160 


Asp Cys Gly Thr Cys Leu Pro Gly Phe Tyr Glu His Gly Asp Gly Cys 
                165                 170                 175     


Val Ser Cys Pro Thr Ser Thr Leu Gly Ser Cys Pro Glu Arg Cys Ala 
            180                 185                 190         


Ala Val Cys Gly Trp Arg Gln Met Phe Trp Val Gln Val Leu Leu Ala 
        195                 200                 205             


Gly Leu Val Val Pro Leu Leu Leu Gly Ala Thr Leu Thr Tyr Thr Tyr 
    210                 215                 220                 


Arg His Cys Trp Pro His Lys Pro Leu Val Thr Ala Asp Glu Ala Gly 
225                 230                 235                 240 


Met Glu Ala Leu Thr Pro Pro Pro Ala Thr His Leu Ser Pro Leu Asp 
                245                 250                 255     


Ser Ala His Thr Leu Leu Ala Pro Pro Asp Ser Ser Glu Lys Ile Cys 
            260                 265                 270         


Thr Val Gln Leu Val Gly Asn Ser Trp Thr Pro Gly Tyr Pro Glu Thr 
        275                 280                 285             


Gln Glu Ala Leu Cys Pro Gln Val Thr Trp Ser Trp Asp Gln Leu Pro 
    290                 295                 300                 


Ser Arg Ala Leu Gly Pro Ala Ala Ala Pro Thr Leu Ser Pro Glu Ser 
305                 310                 315                 320 


Pro Ala Gly Ser Pro Ala Met Met Leu Gln Pro Gly Pro Gln Leu Tyr 
                325                 330                 335     


Asp Val Met Asp Ala Val Pro Ala Arg Arg Trp Lys Glu Phe Val Arg 
            340                 345                 350         


Thr Leu Gly Leu Arg Glu Ala Glu Ile Glu Ala Val Glu Val Glu Ile 
        355                 360                 365             


Gly Arg Phe Arg Asp Gln Gln Tyr Glu Met Leu Lys Arg Trp Arg Gln 
    370                 375                 380                 


Gln Gln Pro Ala Gly Leu Gly Ala Val Tyr Ala Ala Leu Glu Arg Met 
385                 390                 395                 400 


Gly Leu Asp Gly Cys Val Glu Asp Leu Arg Ser Arg Leu Gln Arg Gly 
                405                 410                 415     


Pro 
    


<210>  2897
<211>  621
<212>  PRT
<213>  Homo sapiens

<400>  2897

Met Gly Leu Leu Ser Asp Pro Val Arg Arg Arg Ala Leu Ala Arg Leu 
1               5                   10                  15      


Val Leu Arg Leu Asn Ala Pro Leu Cys Val Leu Ser Tyr Val Ala Gly 
            20                  25                  30          


Ile Ala Trp Phe Leu Ala Leu Val Phe Pro Pro Leu Thr Gln Arg Thr 
        35                  40                  45              


Tyr Met Ser Glu Asn Ala Met Gly Ser Thr Met Val Glu Glu Gln Phe 
    50                  55                  60                  


Ala Gly Gly Asp Arg Ala Arg Ala Phe Ala Arg Asp Phe Ala Ala His 
65                  70                  75                  80  


Arg Lys Lys Ser Gly Ala Leu Pro Val Ala Trp Leu Glu Arg Thr Met 
                85                  90                  95      


Arg Ser Val Gly Leu Glu Val Tyr Thr Gln Ser Phe Ser Arg Lys Leu 
            100                 105                 110         


Pro Phe Pro Asp Glu Thr His Glu Arg Tyr Met Val Ser Gly Thr Asn 
        115                 120                 125             


Val Tyr Gly Ile Leu Arg Ala Pro Arg Ala Ala Ser Thr Glu Ser Leu 
    130                 135                 140                 


Val Leu Thr Val Pro Cys Gly Ser Asp Ser Thr Asn Ser Gln Ala Val 
145                 150                 155                 160 


Gly Leu Leu Leu Ala Leu Ala Ala His Phe Arg Gly Gln Ile Tyr Trp 
                165                 170                 175     


Ala Lys Asp Ile Val Phe Leu Val Thr Glu His Asp Leu Leu Gly Thr 
            180                 185                 190         


Glu Ala Trp Leu Glu Ala Tyr His Asp Val Asn Val Thr Gly Met Gln 
        195                 200                 205             


Ser Ser Pro Leu Gln Gly Arg Ala Gly Ala Ile Gln Ala Ala Val Ala 
    210                 215                 220                 


Leu Glu Leu Ser Ser Asp Val Val Thr Ser Leu Asp Val Ala Val Glu 
225                 230                 235                 240 


Gly Leu Asn Gly Gln Leu Pro Asn Leu Asp Leu Leu Asn Leu Phe Gln 
                245                 250                 255     


Thr Phe Cys Gln Lys Gly Gly Leu Leu Cys Thr Leu Gln Gly Lys Leu 
            260                 265                 270         


Gln Pro Glu Asp Trp Thr Ser Leu Asp Gly Pro Leu Gln Gly Leu Gln 
        275                 280                 285             


Thr Leu Leu Leu Met Val Leu Arg Gln Ala Ser Gly Arg Pro His Gly 
    290                 295                 300                 


Ser His Gly Leu Phe Leu Arg Tyr Arg Val Glu Ala Leu Thr Leu Arg 
305                 310                 315                 320 


Gly Ile Asn Ser Phe Arg Gln Tyr Lys Tyr Asp Leu Val Ala Val Gly 
                325                 330                 335     


Lys Ala Leu Glu Gly Met Phe Arg Lys Leu Asn His Leu Leu Glu Arg 
            340                 345                 350         


Leu His Gln Ser Phe Phe Leu Tyr Leu Leu Pro Gly Leu Ser Arg Phe 
        355                 360                 365             


Val Ser Ile Gly Leu Tyr Met Pro Ala Val Gly Phe Leu Leu Leu Val 
    370                 375                 380                 


Leu Gly Leu Lys Ala Leu Glu Leu Trp Met Gln Leu His Glu Ala Gly 
385                 390                 395                 400 


Met Gly Leu Glu Glu Pro Gly Gly Ala Pro Gly Pro Ser Val Pro Leu 
                405                 410                 415     


Pro Pro Ser Gln Gly Val Gly Leu Ala Ser Leu Val Ala Pro Leu Leu 
            420                 425                 430         


Ile Ser Gln Ala Met Gly Leu Ala Leu Tyr Val Leu Pro Val Leu Gly 
        435                 440                 445             


Gln His Val Ala Thr Gln His Phe Pro Val Ala Glu Ala Glu Ala Val 
    450                 455                 460                 


Val Leu Thr Leu Leu Ala Ile Tyr Ala Ala Gly Leu Ala Leu Pro His 
465                 470                 475                 480 


Asn Thr His Arg Val Val Ser Thr Gln Ala Pro Asp Arg Gly Trp Met 
                485                 490                 495     


Ala Leu Lys Leu Val Ala Leu Ile Tyr Leu Ala Leu Gln Leu Gly Cys 
            500                 505                 510         


Ile Ala Leu Thr Asn Phe Ser Leu Gly Phe Leu Leu Ala Thr Thr Met 
        515                 520                 525             


Val Pro Thr Ala Ala Leu Ala Lys Pro His Gly Pro Arg Thr Leu Tyr 
    530                 535                 540                 


Ala Ala Leu Leu Val Leu Thr Ser Pro Ala Ala Thr Leu Leu Gly Ser 
545                 550                 555                 560 


Leu Phe Leu Trp Arg Glu Leu Gln Glu Ala Pro Leu Ser Leu Ala Glu 
                565                 570                 575     


Gly Trp Gln Leu Phe Leu Ala Ala Leu Ala Gln Gly Val Leu Glu His 
            580                 585                 590         


His Thr Tyr Gly Ala Leu Leu Phe Pro Leu Leu Ser Leu Gly Leu Tyr 
        595                 600                 605             


Pro Cys Trp Leu Leu Phe Trp Asn Val Leu Phe Trp Lys 
    610                 615                 620     


<210>  2898
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  2898

Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 
1               5                   10                  15      


Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 
            20                  25                  30          


Cys Ser Val Ala Arg Val Gly Leu Gly Leu Leu Leu Leu Leu Met Gly 
        35                  40                  45              


Ala Gly Leu Ala Val Gln Gly Trp Phe Leu Leu Gln Leu His Trp Arg 
    50                  55                  60                  


Leu Gly Glu Met Val Thr Arg Leu Pro Asp Gly Pro Ala Gly Ser Trp 
65                  70                  75                  80  


Glu Gln Leu Ile Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala 
                85                  90                  95      


His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu 
            100                 105                 110         


Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr 
        115                 120                 125             


His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr 
    130                 135                 140                 


Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser 
145                 150                 155                 160 


Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu 
                165                 170                 175     


Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser 
            180                 185                 190         


Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His 
        195                 200                 205             


Leu Glu Ala Gly Glu Lys Val Val Val Arg Val Leu Asp Glu Arg Leu 
    210                 215                 220                 


Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
225                 230                 235                 240 


<210>  2899
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  2899

Met Ala Met Met Glu Val Gln Gly Gly Pro Ser Leu Gly Gln Thr Cys 
1               5                   10                  15      


Val Leu Ile Val Ile Phe Thr Val Leu Leu Gln Ser Leu Cys Val Ala 
            20                  25                  30          


Val Thr Tyr Val Tyr Phe Thr Asn Glu Leu Lys Gln Met Gln Asp Lys 
        35                  40                  45              


Tyr Ser Lys Ser Gly Ile Ala Cys Phe Leu Lys Glu Asp Asp Ser Tyr 
    50                  55                  60                  


Trp Asp Pro Asn Asp Glu Glu Ser Met Asn Ser Pro Cys Trp Gln Val 
65                  70                  75                  80  


Lys Trp Gln Leu Arg Gln Leu Val Arg Lys Met Ile Leu Arg Thr Ser 
                85                  90                  95      


Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro 
            100                 105                 110         


Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 
        115                 120                 125             


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    130                 135                 140                 


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
145                 150                 155                 160 


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                165                 170                 175     


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            180                 185                 190         


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        195                 200                 205             


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    210                 215                 220                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
225                 230                 235                 240 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                245                 250                 255     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
            260                 265                 270         


Ser Phe Phe Gly Ala Phe Leu Val Gly 
        275                 280     


<210>  2900
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  2900

Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 


<210>  2901
<211>  832
<212>  PRT
<213>  Homo sapiens

<400>  2901

Met Lys Pro Pro Gly Ser Ser Ser Arg Gln Pro Pro Leu Ala Gly Cys 
1               5                   10                  15      


Ser Leu Ala Gly Ala Ser Cys Gly Pro Gln Arg Gly Pro Ala Gly Ser 
            20                  25                  30          


Val Pro Ala Ser Ala Pro Ala Arg Thr Pro Pro Cys Arg Leu Leu Leu 
        35                  40                  45              


Val Leu Leu Leu Leu Pro Pro Leu Ala Ala Ser Ser Arg Pro Arg Ala 
    50                  55                  60                  


Trp Gly Ala Ala Ala Pro Ser Ala Pro His Trp Asn Glu Thr Ala Glu 
65                  70                  75                  80  


Lys Asn Leu Gly Val Leu Ala Asp Glu Asp Asn Thr Leu Gln Gln Asn 
                85                  90                  95      


Ser Ser Ser Asn Ile Ser Tyr Ser Asn Ala Met Gln Lys Glu Ile Thr 
            100                 105                 110         


Leu Pro Ser Arg Leu Ile Tyr Tyr Ile Asn Gln Asp Ser Glu Ser Pro 
        115                 120                 125             


Tyr His Val Leu Asp Thr Lys Ala Arg His Gln Gln Lys His Asn Lys 
    130                 135                 140                 


Ala Val His Leu Ala Gln Ala Ser Phe Gln Ile Glu Ala Phe Gly Ser 
145                 150                 155                 160 


Lys Phe Ile Leu Asp Leu Ile Leu Asn Asn Gly Leu Leu Ser Ser Asp 
                165                 170                 175     


Tyr Val Glu Ile His Tyr Glu Asn Gly Lys Pro Gln Tyr Ser Lys Gly 
            180                 185                 190         


Gly Glu His Cys Tyr Tyr His Gly Ser Ile Arg Gly Val Lys Asp Ser 
        195                 200                 205             


Lys Val Ala Leu Ser Thr Cys Asn Gly Leu His Gly Met Phe Glu Asp 
    210                 215                 220                 


Asp Thr Phe Val Tyr Met Ile Glu Pro Leu Glu Leu Val His Asp Glu 
225                 230                 235                 240 


Lys Ser Thr Gly Arg Pro His Ile Ile Gln Lys Thr Leu Ala Gly Gln 
                245                 250                 255     


Tyr Ser Lys Gln Met Lys Asn Leu Thr Met Glu Arg Gly Asp Gln Trp 
            260                 265                 270         


Pro Phe Leu Ser Glu Leu Gln Trp Leu Lys Arg Arg Lys Arg Ala Val 
        275                 280                 285             


Asn Pro Ser Arg Gly Ile Phe Glu Glu Met Lys Tyr Leu Glu Leu Met 
    290                 295                 300                 


Ile Val Asn Asp His Lys Thr Tyr Lys Lys His Arg Ser Ser His Ala 
305                 310                 315                 320 


His Thr Asn Asn Phe Ala Lys Ser Val Val Asn Leu Val Asp Ser Ile 
                325                 330                 335     


Tyr Lys Glu Gln Leu Asn Thr Arg Val Val Leu Val Ala Val Glu Thr 
            340                 345                 350         


Trp Thr Glu Lys Asp Gln Ile Asp Ile Thr Thr Asn Pro Val Gln Met 
        355                 360                 365             


Leu His Glu Phe Ser Lys Tyr Arg Gln Arg Ile Lys Gln His Ala Asp 
    370                 375                 380                 


Ala Val His Leu Ile Ser Arg Val Thr Phe His Tyr Lys Arg Ser Ser 
385                 390                 395                 400 


Leu Ser Tyr Phe Gly Gly Val Cys Ser Arg Thr Arg Gly Val Gly Val 
                405                 410                 415     


Asn Glu Tyr Gly Leu Pro Met Ala Val Ala Gln Val Leu Ser Gln Ser 
            420                 425                 430         


Leu Ala Gln Asn Leu Gly Ile Gln Trp Glu Pro Ser Ser Arg Lys Pro 
        435                 440                 445             


Lys Cys Asp Cys Thr Glu Ser Trp Gly Gly Cys Ile Met Glu Glu Thr 
    450                 455                 460                 


Gly Val Ser His Ser Arg Lys Phe Ser Lys Cys Ser Ile Leu Glu Tyr 
465                 470                 475                 480 


Arg Asp Phe Leu Gln Arg Gly Gly Gly Ala Cys Leu Phe Asn Arg Pro 
                485                 490                 495     


Thr Lys Leu Phe Glu Pro Thr Glu Cys Gly Asn Gly Tyr Val Glu Ala 
            500                 505                 510         


Gly Glu Glu Cys Asp Cys Gly Phe His Val Glu Cys Tyr Gly Leu Cys 
        515                 520                 525             


Cys Lys Lys Cys Ser Leu Ser Asn Gly Ala His Cys Ser Asp Gly Pro 
    530                 535                 540                 


Cys Cys Asn Asn Thr Ser Cys Leu Phe Gln Pro Arg Gly Tyr Glu Cys 
545                 550                 555                 560 


Arg Asp Ala Val Asn Glu Cys Asp Ile Thr Glu Tyr Cys Thr Gly Asp 
                565                 570                 575     


Ser Gly Gln Cys Pro Pro Asn Leu His Lys Gln Asp Gly Tyr Ala Cys 
            580                 585                 590         


Asn Gln Asn Gln Gly Arg Cys Tyr Asn Gly Glu Cys Lys Thr Arg Asp 
        595                 600                 605             


Asn Gln Cys Gln Tyr Ile Trp Gly Thr Lys Ala Ala Gly Ser Asp Lys 
    610                 615                 620                 


Phe Cys Tyr Glu Lys Leu Asn Thr Glu Gly Thr Glu Lys Gly Asn Cys 
625                 630                 635                 640 


Gly Lys Asp Gly Asp Arg Trp Ile Gln Cys Ser Lys His Asp Val Phe 
                645                 650                 655     


Cys Gly Phe Leu Leu Cys Thr Asn Leu Thr Arg Ala Pro Arg Ile Gly 
            660                 665                 670         


Gln Leu Gln Gly Glu Ile Ile Pro Thr Ser Phe Tyr His Gln Gly Arg 
        675                 680                 685             


Val Ile Asp Cys Ser Gly Ala His Val Val Leu Asp Asp Asp Thr Asp 
    690                 695                 700                 


Val Gly Tyr Val Glu Asp Gly Thr Pro Cys Gly Pro Ser Met Met Cys 
705                 710                 715                 720 


Leu Asp Arg Lys Cys Leu Gln Ile Gln Ala Leu Asn Met Ser Ser Cys 
                725                 730                 735     


Pro Leu Asp Ser Lys Gly Lys Val Cys Ser Gly His Gly Val Cys Ser 
            740                 745                 750         


Asn Glu Ala Thr Cys Ile Cys Asp Phe Thr Trp Ala Gly Thr Asp Cys 
        755                 760                 765             


Ser Ile Arg Asp Pro Val Arg Asn Leu His Pro Pro Lys Asp Glu Gly 
    770                 775                 780                 


Pro Lys Gly Pro Ser Ala Thr Asn Leu Ile Ile Gly Ser Ile Ala Gly 
785                 790                 795                 800 


Ala Ile Leu Val Ala Ala Ile Val Leu Gly Gly Thr Gly Trp Gly Phe 
                805                 810                 815     


Lys Asn Val Lys Lys Arg Arg Phe Asp Pro Thr Gln Gln Gly Pro Ile 
            820                 825                 830         


<210>  2902
<211>  722
<212>  PRT
<213>  Homo sapiens

<400>  2902

Met Ala Val Asp Gly Thr Leu Val Tyr Ile Arg Val Thr Leu Leu Leu 
1               5                   10                  15      


Leu Trp Leu Gly Val Phe Leu Ser Ile Ser Gly Tyr Cys Gln Ala Gly 
            20                  25                  30          


Pro Ser Gln His Phe Thr Ser Pro Glu Val Val Ile Pro Leu Lys Val 
        35                  40                  45              


Ile Ser Arg Gly Arg Ser Ala Lys Ala Pro Gly Trp Leu Ser Tyr Ser 
    50                  55                  60                  


Leu Arg Phe Gly Gly Gln Lys His Val Val His Met Arg Val Lys Lys 
65                  70                  75                  80  


Leu Leu Val Ser Arg His Leu Pro Val Phe Thr Tyr Thr Asp Asp Arg 
                85                  90                  95      


Ala Leu Leu Glu Asp Gln Leu Phe Ile Pro Asp Asp Cys Tyr Tyr His 
            100                 105                 110         


Gly Tyr Val Glu Ala Ala Pro Glu Ser Leu Val Val Phe Ser Ala Cys 
        115                 120                 125             


Phe Gly Gly Phe Arg Gly Val Leu Lys Ile Ser Gly Leu Thr Tyr Glu 
    130                 135                 140                 


Ile Glu Pro Ile Arg His Ser Ala Thr Phe Glu His Leu Val Tyr Lys 
145                 150                 155                 160 


Ile Asn Ser Asn Glu Thr Gln Phe Pro Ala Met Arg Cys Gly Leu Thr 
                165                 170                 175     


Glu Lys Glu Val Ala Arg Gln Gln Leu Glu Phe Glu Glu Ala Glu Asn 
            180                 185                 190         


Ser Ala Leu Glu Pro Lys Ser Ala Gly Asp Trp Trp Thr His Ala Trp 
        195                 200                 205             


Phe Leu Glu Leu Val Val Val Val Asn His Asp Phe Phe Ile Tyr Ser 
    210                 215                 220                 


Gln Ser Asn Ile Ser Lys Val Gln Glu Asp Val Phe Leu Val Val Asn 
225                 230                 235                 240 


Ile Val Asp Ser Met Tyr Lys Gln Leu Gly Thr Tyr Ile Ile Leu Ile 
                245                 250                 255     


Gly Ile Glu Ile Trp Asn Gln Gly Asn Val Phe Pro Met Thr Ser Ile 
            260                 265                 270         


Glu Gln Val Leu Asn Asp Phe Ser Gln Trp Lys Gln Ile Ser Leu Ser 
        275                 280                 285             


Gln Leu Gln His Asp Ala Ala His Met Phe Ile Lys Asn Ser Leu Ile 
    290                 295                 300                 


Ser Ile Leu Gly Leu Ala Tyr Val Ala Gly Ile Cys Arg Pro Pro Ile 
305                 310                 315                 320 


Asp Cys Gly Val Asp Asn Phe Gln Gly Asp Thr Trp Ser Leu Phe Ala 
                325                 330                 335     


Asn Thr Val Ala His Glu Leu Gly His Thr Leu Gly Met Gln His Asp 
            340                 345                 350         


Glu Glu Phe Cys Phe Cys Gly Glu Arg Gly Cys Ile Met Asn Thr Phe 
        355                 360                 365             


Arg Val Pro Ala Glu Lys Phe Thr Asn Cys Ser Tyr Ala Asp Phe Met 
    370                 375                 380                 


Lys Thr Thr Leu Asn Gln Gly Ser Cys Leu His Asn Pro Pro Arg Leu 
385                 390                 395                 400 


Gly Glu Ile Phe Met Leu Lys Arg Cys Gly Asn Gly Val Val Glu Arg 
                405                 410                 415     


Glu Glu Gln Cys Asp Cys Gly Ser Val Gln Gln Cys Glu Gln Asp Ala 
            420                 425                 430         


Cys Cys Leu Leu Asn Cys Thr Leu Arg Pro Gly Ala Ala Cys Ala Phe 
        435                 440                 445             


Gly Leu Cys Cys Lys Asp Cys Lys Phe Met Pro Ser Gly Glu Leu Cys 
    450                 455                 460                 


Arg Gln Glu Val Asn Glu Cys Asp Leu Pro Glu Trp Cys Asn Gly Thr 
465                 470                 475                 480 


Ser His Gln Cys Pro Glu Asp Arg Tyr Val Gln Asp Gly Ile Pro Cys 
                485                 490                 495     


Ser Asp Ser Ala Tyr Cys Tyr Gln Lys Arg Cys Asn Asn His Asp Gln 
            500                 505                 510         


His Cys Arg Glu Ile Phe Gly Lys Asp Ala Lys Ser Ala Ser Gln Asn 
        515                 520                 525             


Cys Tyr Lys Glu Ile Asn Ser Gln Gly Asn Arg Phe Gly His Cys Gly 
    530                 535                 540                 


Ile Asn Gly Thr Thr Tyr Leu Lys Cys His Ile Ser Asp Val Phe Cys 
545                 550                 555                 560 


Gly Arg Val Gln Cys Glu Asn Val Arg Asp Ile Pro Leu Leu Gln Asp 
                565                 570                 575     


His Phe Thr Leu Gln His Thr His Ile Asn Gly Val Thr Cys Trp Gly 
            580                 585                 590         


Ile Asp Tyr His Leu Arg Met Asn Ile Ser Asp Ile Gly Glu Val Lys 
        595                 600                 605             


Asp Gly Thr Val Cys Gly Pro Gly Lys Ile Cys Ile His Lys Lys Cys 
    610                 615                 620                 


Val Ser Leu Ser Val Leu Ser His Val Cys Leu Pro Glu Thr Cys Asn 
625                 630                 635                 640 


Met Lys Gly Ile Cys Asn Asn Lys His His Cys His Cys Gly Tyr Gly 
                645                 650                 655     


Trp Ser Pro Pro Tyr Cys Gln His Arg Gly Tyr Gly Gly Ser Ile Asp 
            660                 665                 670         


Ser Gly Pro Ala Ser Ala Lys Arg Gly Val Phe Leu Pro Leu Ile Val 
        675                 680                 685             


Ile Pro Ser Leu Ser Val Leu Thr Phe Leu Phe Thr Val Gly Leu Leu 
    690                 695                 700                 


Met Tyr Leu Arg Gln Cys Ser Gly Pro Lys Glu Thr Lys Ala His Ser 
705                 710                 715                 720 


Ser Gly 
        


<210>  2903
<211>  776
<212>  PRT
<213>  Homo sapiens

<400>  2903

Met Val Gln Leu His Gln Asp Thr Asp Pro Gln Ile Pro Lys Gly Gln 
1               5                   10                  15      


Pro Cys Thr Leu Asn Ser Ser Glu Gly Gly Ala Arg Pro Ala Val Pro 
            20                  25                  30          


His Thr Leu Phe Ser Ser Ala Leu Asp Arg Trp Leu His Asn Asp Ser 
        35                  40                  45              


Phe Ile Met Ala Val Gly Glu Pro Leu Val His Ile Arg Val Thr Leu 
    50                  55                  60                  


Leu Leu Leu Trp Phe Gly Met Phe Leu Ser Ile Ser Gly His Ser Gln 
65                  70                  75                  80  


Ala Arg Pro Ser Gln Tyr Phe Thr Ser Pro Glu Val Val Ile Pro Leu 
                85                  90                  95      


Lys Val Ile Ser Arg Gly Arg Gly Ala Lys Ala Pro Gly Trp Leu Ser 
            100                 105                 110         


Tyr Ser Leu Arg Phe Gly Gly Gln Arg Tyr Ile Val His Met Arg Val 
        115                 120                 125             


Asn Lys Leu Leu Phe Ala Ala His Leu Pro Val Phe Thr Tyr Thr Glu 
    130                 135                 140                 


Gln His Ala Leu Leu Gln Asp Gln Pro Phe Ile Gln Asp Asp Cys Tyr 
145                 150                 155                 160 


Tyr His Gly Tyr Val Glu Gly Val Pro Glu Ser Leu Val Ala Leu Ser 
                165                 170                 175     


Thr Cys Ser Gly Gly Phe Leu Gly Met Leu Gln Ile Asn Asp Leu Val 
            180                 185                 190         


Tyr Glu Ile Lys Pro Ile Ser Val Ser Ala Thr Phe Glu His Leu Val 
        195                 200                 205             


Tyr Lys Ile Asp Ser Asp Asp Thr Gln Phe Pro Pro Met Arg Cys Gly 
    210                 215                 220                 


Leu Thr Glu Glu Lys Ile Ala His Gln Met Glu Leu Gln Leu Ser Tyr 
225                 230                 235                 240 


Asn Phe Thr Leu Lys Gln Ser Ser Phe Val Gly Trp Trp Thr His Gln 
                245                 250                 255     


Arg Phe Val Glu Leu Val Val Val Val Asp Asn Ile Arg Tyr Leu Phe 
            260                 265                 270         


Ser Gln Ser Asn Ala Thr Thr Val Gln His Glu Val Phe Asn Val Val 
        275                 280                 285             


Asn Ile Val Asp Ser Phe Tyr His Pro Leu Glu Val Asp Val Ile Leu 
    290                 295                 300                 


Thr Gly Ile Asp Ile Trp Thr Ala Ser Asn Pro Leu Pro Thr Ser Gly 
305                 310                 315                 320 


Asp Leu Asp Asn Val Leu Glu Asp Phe Ser Ile Trp Lys Asn Tyr Asn 
                325                 330                 335     


Leu Asn Asn Arg Leu Gln His Asp Val Ala His Leu Phe Ile Lys Asp 
            340                 345                 350         


Thr Gln Gly Met Lys Leu Gly Val Ala Tyr Val Lys Gly Ile Cys Gln 
        355                 360                 365             


Asn Pro Phe Asn Thr Gly Val Asp Val Phe Glu Asp Asn Arg Leu Val 
    370                 375                 380                 


Val Phe Ala Ile Thr Leu Gly His Glu Leu Gly His Asn Leu Gly Met 
385                 390                 395                 400 


Gln His Asp Thr Gln Trp Cys Val Cys Glu Leu Gln Trp Cys Ile Met 
                405                 410                 415     


His Ala Tyr Arg Lys Val Thr Thr Lys Phe Ser Asn Cys Ser Tyr Ala 
            420                 425                 430         


Gln Tyr Trp Asp Ser Thr Ile Ser Ser Gly Leu Cys Ile Gln Pro Pro 
        435                 440                 445             


Pro Tyr Pro Gly Asn Ile Phe Arg Leu Lys Tyr Cys Gly Asn Leu Val 
    450                 455                 460                 


Val Glu Glu Gly Glu Glu Cys Asp Cys Gly Thr Ile Arg Gln Cys Ala 
465                 470                 475                 480 


Lys Asp Pro Cys Cys Leu Leu Asn Cys Thr Leu His Pro Gly Ala Ala 
                485                 490                 495     


Cys Ala Phe Gly Ile Cys Cys Lys Asp Cys Lys Phe Leu Pro Ser Gly 
            500                 505                 510         


Thr Leu Cys Arg Gln Gln Val Gly Glu Cys Asp Leu Pro Glu Trp Cys 
        515                 520                 525             


Asn Gly Thr Ser His Gln Cys Pro Asp Asp Val Tyr Val Gln Asp Gly 
    530                 535                 540                 


Ile Ser Cys Asn Val Asn Ala Phe Cys Tyr Glu Lys Thr Cys Asn Asn 
545                 550                 555                 560 


His Asp Ile Gln Cys Lys Glu Ile Phe Gly Gln Asp Ala Arg Ser Ala 
                565                 570                 575     


Ser Gln Ser Cys Tyr Gln Glu Ile Asn Thr Gln Gly Asn Arg Phe Gly 
            580                 585                 590         


His Cys Gly Ile Val Gly Thr Thr Tyr Val Lys Cys Trp Thr Pro Asp 
        595                 600                 605             


Ile Met Cys Gly Arg Val Gln Cys Glu Asn Val Gly Val Ile Pro Asn 
    610                 615                 620                 


Leu Ile Glu His Ser Thr Val Gln Gln Phe His Leu Asn Asp Thr Thr 
625                 630                 635                 640 


Cys Trp Gly Thr Asp Tyr His Leu Gly Met Ala Ile Pro Asp Ile Gly 
                645                 650                 655     


Glu Val Lys Asp Gly Thr Val Cys Gly Pro Glu Lys Ile Cys Ile Arg 
            660                 665                 670         


Lys Lys Cys Ala Ser Met Val His Leu Ser Gln Ala Cys Gln Pro Lys 
        675                 680                 685             


Thr Cys Asn Met Arg Gly Ile Cys Asn Asn Lys Gln His Cys His Cys 
    690                 695                 700                 


Asn His Glu Trp Ala Pro Pro Tyr Cys Lys Asp Lys Gly Tyr Gly Gly 
705                 710                 715                 720 


Ser Ala Asp Ser Gly Pro Pro Pro Lys Asn Asn Met Glu Gly Leu Asn 
                725                 730                 735     


Val Met Gly Lys Leu Arg Tyr Leu Ser Leu Leu Cys Leu Leu Pro Leu 
            740                 745                 750         


Val Ala Phe Leu Leu Phe Cys Leu His Val Leu Phe Lys Lys Arg Thr 
        755                 760                 765             


Lys Ser Lys Glu Asp Glu Glu Gly 
    770                 775     


<210>  2904
<211>  819
<212>  PRT
<213>  Homo sapiens

<400>  2904

Met Gly Ser Gly Ala Arg Phe Pro Ser Gly Thr Leu Arg Val Arg Trp 
1               5                   10                  15      


Leu Leu Leu Leu Gly Leu Val Gly Pro Val Leu Gly Ala Ala Arg Pro 
            20                  25                  30          


Gly Phe Gln Gln Thr Ser His Leu Ser Ser Tyr Glu Ile Ile Thr Pro 
        35                  40                  45              


Trp Arg Leu Thr Arg Glu Arg Arg Glu Ala Pro Arg Pro Tyr Ser Lys 
    50                  55                  60                  


Gln Val Ser Tyr Val Ile Gln Ala Glu Gly Lys Glu His Ile Ile His 
65                  70                  75                  80  


Leu Glu Arg Asn Lys Asp Leu Leu Pro Glu Asp Phe Val Val Tyr Thr 
                85                  90                  95      


Tyr Asn Lys Glu Gly Thr Leu Ile Thr Asp His Pro Asn Ile Gln Asn 
            100                 105                 110         


His Cys His Tyr Arg Gly Tyr Val Glu Gly Val His Asn Ser Ser Ile 
        115                 120                 125             


Ala Leu Ser Asp Cys Phe Gly Leu Arg Gly Leu Leu His Leu Glu Asn 
    130                 135                 140                 


Ala Ser Tyr Gly Ile Glu Pro Leu Gln Asn Ser Ser His Phe Glu His 
145                 150                 155                 160 


Ile Ile Tyr Arg Met Asp Asp Val Tyr Lys Glu Pro Leu Lys Cys Gly 
                165                 170                 175     


Val Ser Asn Lys Asp Ile Glu Lys Glu Thr Ala Lys Asp Glu Glu Glu 
            180                 185                 190         


Glu Pro Pro Ser Met Thr Gln Leu Leu Arg Arg Arg Arg Ala Val Leu 
        195                 200                 205             


Pro Gln Thr Arg Tyr Val Glu Leu Phe Ile Val Val Asp Lys Glu Arg 
    210                 215                 220                 


Tyr Asp Met Met Gly Arg Asn Gln Thr Ala Val Arg Glu Glu Met Ile 
225                 230                 235                 240 


Leu Leu Ala Asn Tyr Leu Asp Ser Met Tyr Ile Met Leu Asn Ile Arg 
                245                 250                 255     


Ile Val Leu Val Gly Leu Glu Ile Trp Thr Asn Gly Asn Leu Ile Asn 
            260                 265                 270         


Ile Val Gly Gly Ala Gly Asp Val Leu Gly Asn Phe Val Gln Trp Arg 
        275                 280                 285             


Glu Lys Phe Leu Ile Thr Arg Arg Arg His Asp Ser Ala Gln Leu Val 
    290                 295                 300                 


Leu Lys Lys Gly Phe Gly Gly Thr Ala Gly Met Ala Phe Val Gly Thr 
305                 310                 315                 320 


Val Cys Ser Arg Ser His Ala Gly Gly Ile Asn Val Phe Gly Gln Ile 
                325                 330                 335     


Thr Val Glu Thr Phe Ala Ser Ile Val Ala His Glu Leu Gly His Asn 
            340                 345                 350         


Leu Gly Met Asn His Asp Asp Gly Arg Asp Cys Ser Cys Gly Ala Lys 
        355                 360                 365             


Ser Cys Ile Met Asn Ser Gly Ala Ser Gly Ser Arg Asn Phe Ser Ser 
    370                 375                 380                 


Cys Ser Ala Glu Asp Phe Glu Lys Leu Thr Leu Asn Lys Gly Gly Asn 
385                 390                 395                 400 


Cys Leu Leu Asn Ile Pro Lys Pro Asp Glu Ala Tyr Ser Ala Pro Ser 
                405                 410                 415     


Cys Gly Asn Lys Leu Val Asp Ala Gly Glu Glu Cys Asp Cys Gly Thr 
            420                 425                 430         


Pro Lys Glu Cys Glu Leu Asp Pro Cys Cys Glu Gly Ser Thr Cys Lys 
        435                 440                 445             


Leu Lys Ser Phe Ala Glu Cys Ala Tyr Gly Asp Cys Cys Lys Asp Cys 
    450                 455                 460                 


Arg Phe Leu Pro Gly Gly Thr Leu Cys Arg Gly Lys Thr Ser Glu Cys 
465                 470                 475                 480 


Asp Val Pro Glu Tyr Cys Asn Gly Ser Ser Gln Phe Cys Gln Pro Asp 
                485                 490                 495     


Val Phe Ile Gln Asn Gly Tyr Pro Cys Gln Asn Asn Lys Ala Tyr Cys 
            500                 505                 510         


Tyr Asn Gly Met Cys Gln Tyr Tyr Asp Ala Gln Cys Gln Val Ile Phe 
        515                 520                 525             


Gly Ser Lys Ala Lys Ala Ala Pro Lys Asp Cys Phe Ile Glu Val Asn 
    530                 535                 540                 


Ser Lys Gly Asp Arg Phe Gly Asn Cys Gly Phe Ser Gly Asn Glu Tyr 
545                 550                 555                 560 


Lys Lys Cys Ala Thr Gly Asn Ala Leu Cys Gly Lys Leu Gln Cys Glu 
                565                 570                 575     


Asn Val Gln Glu Ile Pro Val Phe Gly Ile Val Pro Ala Ile Ile Gln 
            580                 585                 590         


Thr Pro Ser Arg Gly Thr Lys Cys Trp Gly Val Asp Phe Gln Leu Gly 
        595                 600                 605             


Ser Asp Val Pro Asp Pro Gly Met Val Asn Glu Gly Thr Lys Cys Gly 
    610                 615                 620                 


Ala Gly Lys Ile Cys Arg Asn Phe Gln Cys Val Asp Ala Ser Val Leu 
625                 630                 635                 640 


Asn Tyr Asp Cys Asp Val Gln Lys Lys Cys His Gly His Gly Val Cys 
                645                 650                 655     


Asn Ser Asn Lys Asn Cys His Cys Glu Asn Gly Trp Ala Pro Pro Asn 
            660                 665                 670         


Cys Glu Thr Lys Gly Tyr Gly Gly Ser Val Asp Ser Gly Pro Thr Tyr 
        675                 680                 685             


Asn Glu Met Asn Thr Ala Leu Arg Asp Gly Leu Leu Val Phe Phe Phe 
    690                 695                 700                 


Leu Ile Val Pro Leu Ile Val Cys Ala Ile Phe Ile Phe Ile Lys Arg 
705                 710                 715                 720 


Asp Gln Leu Trp Arg Ser Tyr Phe Arg Lys Lys Arg Ser Gln Thr Tyr 
                725                 730                 735     


Glu Ser Asp Gly Lys Asn Gln Ala Asn Pro Ser Arg Gln Pro Gly Ser 
            740                 745                 750         


Val Pro Arg His Val Ser Pro Val Thr Pro Pro Arg Glu Val Pro Ile 
        755                 760                 765             


Tyr Ala Asn Arg Phe Ala Val Pro Thr Tyr Ala Ala Lys Gln Pro Gln 
    770                 775                 780                 


Gln Phe Pro Ser Arg Pro Pro Pro Pro Gln Pro Lys Val Ser Ser Gln 
785                 790                 795                 800 


Gly Asn Leu Ile Pro Ala Arg Pro Ala Pro Ala Pro Pro Leu Tyr Ser 
                805                 810                 815     


Ser Leu Thr 
            


<210>  2905
<211>  754
<212>  PRT
<213>  Homo sapiens

<400>  2905

Met Leu Pro Gly Cys Ile Phe Leu Met Ile Leu Leu Ile Pro Gln Val 
1               5                   10                  15      


Lys Glu Lys Phe Ile Leu Gly Val Glu Gly Gln Gln Leu Val Arg Pro 
            20                  25                  30          


Lys Lys Leu Pro Leu Ile Gln Lys Arg Asp Thr Gly His Thr His Asp 
        35                  40                  45              


Asp Asp Ile Leu Lys Thr Tyr Glu Glu Glu Leu Leu Tyr Glu Ile Lys 
    50                  55                  60                  


Leu Asn Arg Lys Thr Leu Val Leu His Leu Leu Arg Ser Arg Glu Phe 
65                  70                  75                  80  


Leu Gly Ser Asn Tyr Ser Glu Thr Phe Tyr Ser Met Lys Gly Glu Ala 
                85                  90                  95      


Phe Thr Arg His Pro Gln Ile Met Asp His Cys Phe Tyr Gln Gly Ser 
            100                 105                 110         


Ile Val His Glu Tyr Asp Ser Ala Ala Ser Ile Ser Thr Cys Asn Gly 
        115                 120                 125             


Leu Arg Gly Phe Phe Arg Ile Asn Asp Gln Arg Tyr Leu Ile Glu Pro 
    130                 135                 140                 


Val Lys Tyr Ser Asp Glu Gly Glu His Leu Val Phe Lys Tyr Asn Leu 
145                 150                 155                 160 


Arg Val Pro Tyr Gly Ala Asn Tyr Ser Cys Thr Glu Leu Asn Phe Thr 
                165                 170                 175     


Arg Lys Thr Val Pro Gly Asp Asn Glu Ser Glu Glu Asp Ser Lys Ile 
            180                 185                 190         


Lys Gly Ile His Asp Glu Lys Tyr Val Glu Leu Phe Ile Val Ala Asp 
        195                 200                 205             


Asp Thr Val Tyr Arg Arg Asn Gly His Pro His Asn Lys Leu Arg Asn 
    210                 215                 220                 


Arg Ile Trp Gly Met Val Asn Phe Val Asn Met Ile Tyr Lys Thr Leu 
225                 230                 235                 240 


Asn Ile His Val Thr Leu Val Gly Ile Glu Ile Trp Thr His Glu Asp 
                245                 250                 255     


Lys Ile Glu Leu Tyr Ser Asn Ile Glu Thr Thr Leu Leu Arg Phe Ser 
            260                 265                 270         


Phe Trp Gln Glu Lys Ile Leu Lys Thr Arg Lys Asp Phe Asp His Val 
        275                 280                 285             


Val Leu Leu Ser Gly Lys Trp Leu Tyr Ser His Val Gln Gly Ile Ser 
    290                 295                 300                 


Tyr Pro Gly Gly Met Cys Leu Pro Tyr Tyr Ser Thr Ser Ile Ile Lys 
305                 310                 315                 320 


Asp Leu Leu Pro Asp Thr Asn Ile Ile Ala Asn Arg Met Ala His Gln 
                325                 330                 335     


Leu Gly His Asn Leu Gly Met Gln His Asp Glu Phe Pro Cys Thr Cys 
            340                 345                 350         


Pro Ser Gly Lys Cys Val Met Asp Ser Asp Gly Ser Ile Pro Ala Leu 
        355                 360                 365             


Lys Phe Ser Lys Cys Ser Gln Asn Gln Tyr His Gln Tyr Leu Lys Asp 
    370                 375                 380                 


Tyr Lys Pro Thr Cys Met Leu Asn Ile Pro Phe Pro Tyr Asn Phe His 
385                 390                 395                 400 


Asp Phe Gln Phe Cys Gly Asn Lys Lys Leu Asp Glu Gly Glu Glu Cys 
                405                 410                 415     


Asp Cys Gly Pro Ala Gln Glu Cys Thr Asn Pro Cys Cys Asp Ala His 
            420                 425                 430         


Thr Cys Val Leu Lys Pro Gly Phe Thr Cys Ala Glu Gly Glu Cys Cys 
        435                 440                 445             


Glu Ser Cys Gln Ile Lys Lys Ala Gly Ser Ile Cys Arg Pro Ala Lys 
    450                 455                 460                 


Asp Glu Cys Asp Phe Pro Glu Met Cys Thr Gly His Ser Pro Ala Cys 
465                 470                 475                 480 


Pro Lys Asp Gln Phe Arg Val Asn Gly Phe Pro Cys Lys Asn Ser Glu 
                485                 490                 495     


Gly Tyr Cys Phe Met Gly Lys Cys Pro Thr Arg Glu Asp Gln Cys Ser 
            500                 505                 510         


Glu Leu Phe Asp Asp Glu Ala Ile Glu Ser His Asp Ile Cys Tyr Lys 
        515                 520                 525             


Met Asn Thr Lys Gly Asn Lys Phe Gly Tyr Cys Lys Asn Lys Glu Asn 
    530                 535                 540                 


Arg Phe Leu Pro Cys Glu Glu Lys Asp Val Arg Cys Gly Lys Ile Tyr 
545                 550                 555                 560 


Cys Thr Gly Gly Glu Leu Ser Ser Leu Leu Gly Glu Asp Lys Thr Tyr 
                565                 570                 575     


His Leu Lys Asp Pro Gln Lys Asn Ala Thr Val Lys Cys Lys Thr Ile 
            580                 585                 590         


Phe Leu Tyr His Asp Ser Thr Asp Ile Gly Leu Val Ala Ser Gly Thr 
        595                 600                 605             


Lys Cys Gly Glu Gly Met Val Cys Asn Asn Gly Glu Cys Leu Asn Met 
    610                 615                 620                 


Glu Lys Val Tyr Ile Ser Thr Asn Cys Pro Ser Gln Cys Asn Glu Asn 
625                 630                 635                 640 


Pro Val Asp Gly His Gly Leu Gln Cys His Cys Glu Glu Gly Gln Ala 
                645                 650                 655     


Pro Val Ala Cys Glu Glu Thr Leu His Val Thr Asn Ile Thr Ile Leu 
            660                 665                 670         


Val Val Val Leu Val Leu Val Ile Val Gly Ile Gly Val Leu Ile Leu 
        675                 680                 685             


Leu Val Arg Tyr Arg Lys Cys Ile Lys Leu Lys Gln Val Gln Ser Pro 
    690                 695                 700                 


Pro Thr Glu Thr Leu Gly Val Glu Asn Lys Gly Tyr Phe Gly Asp Glu 
705                 710                 715                 720 


Gln Gln Ile Arg Thr Glu Pro Ile Leu Pro Glu Ile His Phe Leu Asn 
                725                 730                 735     


Lys Pro Ala Ser Lys Asp Ser Arg Gly Ile Ala Asp Pro Asn Gln Ser 
            740                 745                 750         


Ala Lys 
        


<210>  2906
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  2906

Met Thr Glu Leu Arg Gln Arg Val Ala His Glu Pro Val Ala Pro Pro 
1               5                   10                  15      


Glu Asp Lys Glu Ser Glu Ser Glu Ala Lys Val Asp Gly Glu Thr Ala 
            20                  25                  30          


Ser Asp Ser Glu Ser Arg Ala Glu Ser Ala Pro Leu Pro Val Ser Ala 
        35                  40                  45              


Asp Asp Thr Pro Glu Val Leu Asn Arg Ala Leu Ser Asn Leu Ser Ser 
    50                  55                  60                  


Arg Trp Lys Asn Trp Trp Val Arg Gly Ile Leu Thr Leu Ala Met Ile 
65                  70                  75                  80  


Ala Phe Phe Phe Ile Ile Ile Tyr Leu Gly Pro Met Val Leu Met Ile 
                85                  90                  95      


Ile Val Met Cys Val Gln Ile Lys Cys Phe His Glu Ile Ile Thr Ile 
            100                 105                 110         


Gly Tyr Asn Val Tyr His Ser Tyr Asp Leu Pro Trp Phe Arg Thr Leu 
        115                 120                 125             


Ser Trp Tyr Phe Leu Leu Cys Val Asn Tyr Phe Phe Tyr Gly Glu Thr 
    130                 135                 140                 


Val Thr Asp Tyr Phe Phe Thr Leu Val Gln Arg Glu Glu Pro Leu Arg 
145                 150                 155                 160 


Ile Leu Ser Lys Tyr His Arg Phe Ile Ser Phe Thr Leu Tyr Leu Ile 
                165                 170                 175     


Gly Phe Cys Met Phe Val Leu Ser Leu Val Lys Lys His Tyr Arg Leu 
            180                 185                 190         


Gln Phe Tyr Met Phe Gly Trp Thr His Val Thr Leu Leu Ile Val Val 
        195                 200                 205             


Thr Gln Ser His Leu Val Ile His Asn Leu Phe Glu Gly Met Ile Trp 
    210                 215                 220                 


Phe Ile Val Pro Ile Ser Cys Val Ile Cys Asn Asp Ile Met Ala Tyr 
225                 230                 235                 240 


Met Phe Gly Phe Phe Phe Gly Arg Thr Pro Leu Ile Lys Leu Ser Pro 
                245                 250                 255     


Lys Lys Thr Trp Glu Gly Phe Ile Gly Gly Phe Phe Ala Thr Val Val 
            260                 265                 270         


Phe Gly Leu Leu Leu Ser Tyr Val Met Ser Gly Tyr Arg Cys Phe Val 
        275                 280                 285             


Cys Pro Val Glu Tyr Asn Asn Asp Thr Asn Ser Phe Thr Val Asp Cys 
    290                 295                 300                 


Glu Pro Ser Asp Leu Phe Arg Leu Gln Glu Tyr Asn Ile Pro Gly Val 
305                 310                 315                 320 


Ile Gln Ser Val Ile Gly Trp Lys Thr Val Arg Met Tyr Pro Phe Gln 
                325                 330                 335     


Ile His Ser Ile Ala Leu Ser Thr Phe Ala Ser Leu Ile Gly Pro Phe 
            340                 345                 350         


Gly Gly Phe Phe Ala Ser Gly Phe Lys Arg Ala Phe Lys Ile Lys Asp 
        355                 360                 365             


Phe Ala Asn Thr Ile Pro Gly His Gly Gly Ile Met Asp Arg Phe Asp 
    370                 375                 380                 


Cys Gln Tyr Leu Met Ala Thr Phe Val Asn Val Tyr Ile Ala Ser Phe 
385                 390                 395                 400 


Ile Arg Gly Pro Asn Pro Ser Lys Leu Ile Gln Gln Phe Leu Thr Leu 
                405                 410                 415     


Arg Pro Asp Gln Gln Leu His Ile Phe Asn Thr Leu Arg Ser His Leu 
            420                 425                 430         


Ile Asp Lys Gly Met Leu Thr Ser Thr Thr Glu Asp Glu 
        435                 440                 445 


<210>  2907
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  2907

Met Glu Pro Pro Gly Asp Trp Gly Pro Pro Pro Trp Arg Ser Thr Pro 
1               5                   10                  15      


Lys Thr Asp Val Leu Arg Leu Val Leu Tyr Leu Thr Phe Leu Gly Ala 
            20                  25                  30          


Pro Cys Tyr Ala Pro Ala Leu Pro Ser Cys Lys Glu Asp Glu Tyr Pro 
        35                  40                  45              


Val Gly Ser Glu Cys Cys Pro Lys Cys Ser Pro Gly Tyr Arg Val Lys 
    50                  55                  60                  


Glu Ala Cys Gly Glu Leu Thr Gly Thr Val Cys Glu Pro Cys Pro Pro 
65                  70                  75                  80  


Gly Thr Tyr Ile Ala His Leu Asn Gly Leu Ser Lys Cys Leu Gln Cys 
                85                  90                  95      


Gln Met Cys Asp Pro Ala Met Gly Leu Arg Ala Ser Arg Asn Cys Ser 
            100                 105                 110         


Arg Thr Glu Asn Ala Val Cys Gly Cys Ser Pro Gly His Phe Cys Ile 
        115                 120                 125             


Val Gln Asp Gly Asp His Cys Ala Ala Cys Arg Ala Tyr Ala Thr Ser 
    130                 135                 140                 


Ser Pro Gly Gln Arg Val Gln Lys Gly Gly Thr Glu Ser Gln Asp Thr 
145                 150                 155                 160 


Leu Cys Gln Asn Cys Pro Pro Gly Thr Phe Ser Pro Asn Gly Thr Leu 
                165                 170                 175     


Glu Glu Cys Gln His Gln Thr Lys Cys Ser Trp Leu Val Thr Lys Ala 
            180                 185                 190         


Gly Ala Gly Thr Ser Ser Ser His Trp Val Trp Trp Phe Leu Ser Gly 
        195                 200                 205             


Ser Leu Val Ile Val Ile Val Cys Ser Thr Val Gly Leu Ile Ile Cys 
    210                 215                 220                 


Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val Ser 
225                 230                 235                 240 


Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile Glu 
                245                 250                 255     


Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu Glu Thr 
            260                 265                 270         


Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His 
        275                 280             


<210>  2908
<211>  616
<212>  PRT
<213>  Homo sapiens

<400>  2908

Met Ala Pro Arg Ala Arg Arg Arg Arg Pro Leu Phe Ala Leu Leu Leu 
1               5                   10                  15      


Leu Cys Ala Leu Leu Ala Arg Leu Gln Val Ala Leu Gln Ile Ala Pro 
            20                  25                  30          


Pro Cys Thr Ser Glu Lys His Tyr Glu His Leu Gly Arg Cys Cys Asn 
        35                  40                  45              


Lys Cys Glu Pro Gly Lys Tyr Met Ser Ser Lys Cys Thr Thr Thr Ser 
    50                  55                  60                  


Asp Ser Val Cys Leu Pro Cys Gly Pro Asp Glu Tyr Leu Asp Ser Trp 
65                  70                  75                  80  


Asn Glu Glu Asp Lys Cys Leu Leu His Lys Val Cys Asp Thr Gly Lys 
                85                  90                  95      


Ala Leu Val Ala Val Val Ala Gly Asn Ser Thr Thr Pro Arg Arg Cys 
            100                 105                 110         


Ala Cys Thr Ala Gly Tyr His Trp Ser Gln Asp Cys Glu Cys Cys Arg 
        115                 120                 125             


Arg Asn Thr Glu Cys Ala Pro Gly Leu Gly Ala Gln His Pro Leu Gln 
    130                 135                 140                 


Leu Asn Lys Asp Thr Val Cys Lys Pro Cys Leu Ala Gly Tyr Phe Ser 
145                 150                 155                 160 


Asp Ala Phe Ser Ser Thr Asp Lys Cys Arg Pro Trp Thr Asn Cys Thr 
                165                 170                 175     


Phe Leu Gly Lys Arg Val Glu His His Gly Thr Glu Lys Ser Asp Ala 
            180                 185                 190         


Val Cys Ser Ser Ser Leu Pro Ala Arg Lys Pro Pro Asn Glu Pro His 
        195                 200                 205             


Val Tyr Leu Pro Gly Leu Ile Ile Leu Leu Leu Phe Ala Ser Val Ala 
    210                 215                 220                 


Leu Val Ala Ala Ile Ile Phe Gly Val Cys Tyr Arg Lys Lys Gly Lys 
225                 230                 235                 240 


Ala Leu Thr Ala Asn Leu Trp His Trp Ile Asn Glu Ala Cys Gly Arg 
                245                 250                 255     


Leu Ser Gly Asp Lys Glu Ser Ser Gly Asp Ser Cys Val Ser Thr His 
            260                 265                 270         


Thr Ala Asn Phe Gly Gln Gln Gly Ala Cys Glu Gly Val Leu Leu Leu 
        275                 280                 285             


Thr Leu Glu Glu Lys Thr Phe Pro Glu Asp Met Cys Tyr Pro Asp Gln 
    290                 295                 300                 


Gly Gly Val Cys Gln Gly Thr Cys Val Gly Gly Gly Pro Tyr Ala Gln 
305                 310                 315                 320 


Gly Glu Asp Ala Arg Met Leu Ser Leu Val Ser Lys Thr Glu Ile Glu 
                325                 330                 335     


Glu Asp Ser Phe Arg Gln Met Pro Thr Glu Asp Glu Tyr Met Asp Arg 
            340                 345                 350         


Pro Ser Gln Pro Thr Asp Gln Leu Leu Phe Leu Thr Glu Pro Gly Ser 
        355                 360                 365             


Lys Ser Thr Pro Pro Phe Ser Glu Pro Leu Glu Val Gly Glu Asn Asp 
    370                 375                 380                 


Ser Leu Ser Gln Cys Phe Thr Gly Thr Gln Ser Thr Val Gly Ser Glu 
385                 390                 395                 400 


Ser Cys Asn Cys Thr Glu Pro Leu Cys Arg Thr Asp Trp Thr Pro Met 
                405                 410                 415     


Ser Ser Glu Asn Tyr Leu Gln Lys Glu Val Asp Ser Gly His Cys Pro 
            420                 425                 430         


His Trp Ala Ala Ser Pro Ser Pro Asn Trp Ala Asp Val Cys Thr Gly 
        435                 440                 445             


Cys Arg Asn Pro Pro Gly Glu Asp Cys Glu Pro Leu Val Gly Ser Pro 
    450                 455                 460                 


Lys Arg Gly Pro Leu Pro Gln Cys Ala Tyr Gly Met Gly Leu Pro Pro 
465                 470                 475                 480 


Glu Glu Glu Ala Ser Arg Thr Glu Ala Arg Asp Gln Pro Glu Asp Gly 
                485                 490                 495     


Ala Asp Gly Arg Leu Pro Ser Ser Ala Arg Ala Gly Ala Gly Ser Gly 
            500                 505                 510         


Ser Ser Pro Gly Gly Gln Ser Pro Ala Ser Gly Asn Val Thr Gly Asn 
        515                 520                 525             


Ser Asn Ser Thr Phe Ile Ser Ser Gly Gln Val Met Asn Phe Lys Gly 
    530                 535                 540                 


Asp Ile Ile Val Val Tyr Val Ser Gln Thr Ser Gln Glu Gly Ala Ala 
545                 550                 555                 560 


Ala Ala Ala Glu Pro Met Gly Arg Pro Val Gln Glu Glu Thr Leu Ala 
                565                 570                 575     


Arg Arg Asp Ser Phe Ala Gly Asn Gly Pro Arg Phe Pro Asp Pro Cys 
            580                 585                 590         


Gly Gly Pro Glu Gly Leu Arg Glu Pro Glu Lys Ala Ser Arg Pro Val 
        595                 600                 605             


Gln Glu Gln Gly Gly Ala Lys Ala 
    610                 615     


<210>  2909
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  2909

Met Ala Arg Ile Pro Lys Thr Leu Lys Phe Val Val Val Ile Val Ala 
1               5                   10                  15      


Val Leu Leu Pro Val Leu Ala Tyr Ser Ala Thr Thr Ala Arg Gln Glu 
            20                  25                  30          


Glu Val Pro Gln Gln Thr Val Ala Pro Gln Gln Gln Arg His Ser Phe 
        35                  40                  45              


Lys Gly Glu Glu Cys Pro Ala Gly Ser His Arg Ser Glu His Thr Gly 
    50                  55                  60                  


Ala Cys Asn Pro Cys Thr Glu Gly Val Asp Tyr Thr Asn Ala Ser Asn 
65                  70                  75                  80  


Asn Glu Pro Ser Cys Phe Pro Cys Thr Val Cys Lys Ser Asp Gln Lys 
                85                  90                  95      


His Lys Ser Ser Cys Thr Met Thr Arg Asp Thr Val Cys Gln Cys Lys 
            100                 105                 110         


Glu Gly Thr Phe Arg Asn Glu Asn Ser Pro Glu Met Cys Arg Lys Cys 
        115                 120                 125             


Ser Arg Cys Pro Ser Gly Glu Val Gln Val Ser Asn Cys Thr Ser Trp 
    130                 135                 140                 


Asp Asp Ile Gln Cys Val Glu Glu Phe Gly Ala Asn Ala Thr Val Glu 
145                 150                 155                 160 


Thr Pro Ala Ala Glu Glu Thr Met Asn Thr Ser Pro Gly Thr Pro Ala 
                165                 170                 175     


Pro Ala Ala Glu Glu Thr Met Asn Thr Ser Pro Gly Thr Pro Ala Pro 
            180                 185                 190         


Ala Ala Glu Glu Thr Met Thr Thr Ser Pro Gly Thr Pro Ala Pro Ala 
        195                 200                 205             


Ala Glu Glu Thr Met Thr Thr Ser Pro Gly Thr Pro Ala Pro Ala Ala 
    210                 215                 220                 


Glu Glu Thr Met Thr Thr Ser Pro Gly Thr Pro Ala Ser Ser His Tyr 
225                 230                 235                 240 


Leu Ser Cys Thr Ile Val Gly Ile Ile Val Leu Ile Val Leu Leu Ile 
                245                 250                 255     


Val Phe Val 
            


<210>  2910
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  2910

Met Glu Gln Arg Gly Gln Asn Ala Pro Ala Ala Ser Gly Ala Arg Lys 
1               5                   10                  15      


Arg His Gly Pro Gly Pro Arg Glu Ala Arg Gly Ala Arg Pro Gly Pro 
            20                  25                  30          


Arg Val Pro Lys Thr Leu Val Leu Val Val Ala Ala Val Leu Leu Leu 
        35                  40                  45              


Val Ser Ala Glu Ser Ala Leu Ile Thr Gln Gln Asp Leu Ala Pro Gln 
    50                  55                  60                  


Gln Arg Ala Ala Pro Gln Gln Lys Arg Ser Ser Pro Ser Glu Gly Leu 
65                  70                  75                  80  


Cys Pro Pro Gly His His Ile Ser Glu Asp Gly Arg Asp Cys Ile Ser 
                85                  90                  95      


Cys Lys Tyr Gly Gln Asp Tyr Ser Thr His Trp Asn Asp Leu Leu Phe 
            100                 105                 110         


Cys Leu Arg Cys Thr Arg Cys Asp Ser Gly Glu Val Glu Leu Ser Pro 
        115                 120                 125             


Cys Thr Thr Thr Arg Asn Thr Val Cys Gln Cys Glu Glu Gly Thr Phe 
    130                 135                 140                 


Arg Glu Glu Asp Ser Pro Glu Met Cys Arg Lys Cys Arg Thr Gly Cys 
145                 150                 155                 160 


Pro Arg Gly Met Val Lys Val Gly Asp Cys Thr Pro Trp Ser Asp Ile 
                165                 170                 175     


Glu Cys Val His Lys Glu Ser Gly Thr Lys His Ser Gly Glu Val Pro 
            180                 185                 190         


Ala Val Glu Glu Thr Val Thr Ser Ser Pro Gly Thr Pro Ala Ser Pro 
        195                 200                 205             


Cys Ser Leu Ser Gly Ile Ile Ile Gly Val Thr Val Ala Ala Val Val 
    210                 215                 220                 


Leu Ile Val Ala Val Phe Val Cys Lys Ser Leu Leu Trp Lys Lys Val 
225                 230                 235                 240 


Leu Pro Tyr Leu Lys Gly Ile Cys Ser Gly Gly Gly Gly Asp Pro Glu 
                245                 250                 255     


Arg Val Asp Arg Ser Ser Gln Arg Pro Gly Ala Glu Asp Asn Val Leu 
            260                 265                 270         


Asn Glu Ile Val Ser Ile Leu Gln Pro Thr Gln Val Pro Glu Gln Glu 
        275                 280                 285             


Met Glu Val Gln Glu Pro Ala Glu Pro Thr Gly Val Asn Met Leu Ser 
    290                 295                 300                 


Pro Gly Glu Ser Glu His Leu Leu Glu Pro Ala Glu Ala Glu Arg Ser 
305                 310                 315                 320 


Gln Arg Arg Arg Leu Leu Val Pro Ala Asn Glu Gly Asp Pro Thr Glu 
                325                 330                 335     


Thr Leu Arg Gln Cys Phe Asp Asp Phe Ala Asp Leu Val Pro Phe Asp 
            340                 345                 350         


Ser Trp Glu Pro Leu Met Arg Lys Leu Gly Leu Met Asp Asn Glu Ile 
        355                 360                 365             


Lys Val Ala Lys Ala Glu Ala Ala Gly His Arg Asp Thr Leu Tyr Thr 
    370                 375                 380                 


Met Leu Ile Lys Trp Val Asn Lys Thr Gly Arg Asp Ala Ser Val His 
385                 390                 395                 400 


Thr Leu Leu Asp Ala Leu Glu Thr Leu Gly Glu Arg Leu Ala Lys Gln 
                405                 410                 415     


Lys Ile Glu Asp His Leu Leu Ser Ser Gly Lys Phe Met Tyr Leu Glu 
            420                 425                 430         


Gly Asn Ala Asp Ser Ala Met Ser 
        435                 440 


<210>  2911
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  2911

Met Ala Pro Pro Pro Ala Arg Val His Leu Gly Ala Phe Leu Ala Val 
1               5                   10                  15      


Thr Pro Asn Pro Gly Ser Ala Ala Ser Gly Thr Glu Ala Ala Ala Ala 
            20                  25                  30          


Thr Pro Ser Lys Val Trp Gly Ser Ser Ala Gly Arg Ile Glu Pro Arg 
        35                  40                  45              


Gly Gly Gly Arg Gly Ala Leu Pro Thr Ser Met Gly Gln His Gly Pro 
    50                  55                  60                  


Ser Ala Arg Ala Arg Ala Gly Arg Ala Pro Gly Pro Arg Pro Ala Arg 
65                  70                  75                  80  


Glu Ala Ser Pro Arg Leu Arg Val His Lys Thr Phe Lys Phe Val Val 
                85                  90                  95      


Val Gly Val Leu Leu Gln Val Val Pro Ser Ser Ala Ala Thr Ile Lys 
            100                 105                 110         


Leu His Asp Gln Ser Ile Gly Thr Gln Gln Trp Glu His Ser Pro Leu 
        115                 120                 125             


Gly Glu Leu Cys Pro Pro Gly Ser His Arg Ser Glu His Pro Gly Ala 
    130                 135                 140                 


Cys Asn Arg Cys Thr Glu Gly Val Gly Tyr Thr Asn Ala Ser Asn Asn 
145                 150                 155                 160 


Leu Phe Ala Cys Leu Pro Cys Thr Ala Cys Lys Ser Asp Glu Glu Glu 
                165                 170                 175     


Arg Ser Pro Cys Thr Thr Thr Arg Asn Thr Ala Cys Gln Cys Lys Pro 
            180                 185                 190         


Gly Thr Phe Arg Asn Asp Asn Ser Ala Glu Met Cys Arg Lys Cys Ser 
        195                 200                 205             


Arg Gly Cys Pro Arg Gly Met Val Lys Val Lys Asp Cys Thr Pro Trp 
    210                 215                 220                 


Ser Asp Ile Glu Cys Val His Lys Glu Ser Gly Asn Gly His Asn Ile 
225                 230                 235                 240 


Trp Val Ile Leu Val Val Thr Leu Val Val Pro Leu Leu Leu Val Ala 
                245                 250                 255     


Val Leu Ile Val Cys Cys Cys Ile Gly Ser Gly Cys Gly Gly Asp Pro 
            260                 265                 270         


Lys Cys Met Asp Arg Val Cys Phe Trp Arg Leu Gly Leu Leu Arg Gly 
        275                 280                 285             


Pro Gly Ala Glu Asp Asn Ala His Asn Glu Ile Leu Ser Asn Ala Asp 
    290                 295                 300                 


Ser Leu Ser Thr Phe Val Ser Glu Gln Gln Met Glu Ser Gln Glu Pro 
305                 310                 315                 320 


Ala Asp Leu Thr Gly Val Thr Val Gln Ser Pro Gly Glu Ala Gln Cys 
                325                 330                 335     


Leu Leu Gly Pro Ala Glu Ala Glu Gly Ser Gln Arg Arg Arg Leu Leu 
            340                 345                 350         


Val Pro Ala Asn Gly Ala Asp Pro Thr Glu Thr Leu Met Leu Phe Phe 
        355                 360                 365             


Asp Lys Phe Ala Asn Ile Val Pro Phe Asp Ser Trp Asp Gln Leu Met 
    370                 375                 380                 


Arg Gln Leu Asp Leu Thr Lys Asn Glu Ile Asp Val Val Arg Ala Gly 
385                 390                 395                 400 


Thr Ala Gly Pro Gly Asp Ala Leu Tyr Ala Met Leu Met Lys Trp Val 
                405                 410                 415     


Asn Lys Thr Gly Arg Asn Ala Ser Ile His Thr Leu Leu Asp Ala Leu 
            420                 425                 430         


Glu Arg Met Glu Glu Arg His Ala Arg Glu Lys Ile Gln Asp Leu Leu 
        435                 440                 445             


Val Asp Ser Gly Lys Phe Ile Tyr Leu Glu Asp Gly Thr Gly Ser Ala 
    450                 455                 460                 


Val Ser Leu Glu 
465             


<210>  2912
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  2912

Met Asp Ala Trp Val Arg Phe Ser Ala Gln Ser Gln Ala Arg Glu Arg 
1               5                   10                  15      


Leu Cys Arg Ala Ala Gln Tyr Ala Cys Ser Leu Leu Gly His Ala Leu 
            20                  25                  30          


Gln Arg His Gly Ala Ser Pro Glu Leu Gln Lys Gln Ile Arg Gln Leu 
        35                  40                  45              


Glu Ser His Leu Ser Leu Gly Arg Lys Leu Leu Arg Leu Gly Asn Ser 
    50                  55                  60                  


Ala Asp Ala Leu Glu Ser Ala Lys Arg Ala Val His Leu Ser Asp Val 
65                  70                  75                  80  


Val Leu Arg Phe Cys Ile Thr Val Ser His Leu Asn Arg Ala Leu Tyr 
                85                  90                  95      


Phe Ala Cys Asp Asn Val Leu Trp Ala Gly Lys Ser Gly Leu Ala Pro 
            100                 105                 110         


Arg Val Asp Gln Glu Lys Trp Ala Gln Arg Ser Phe Arg Tyr Tyr Leu 
        115                 120                 125             


Phe Ser Leu Ile Met Asn Leu Ser Arg Asp Ala Tyr Glu Ile Arg Leu 
    130                 135                 140                 


Leu Met Glu Gln Glu Ser Ser Ala Cys Ser Arg Arg Leu Lys Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Val Pro Gly Gly Ser Glu Thr Gly Gly Leu Gly Gly Pro 
                165                 170                 175     


Gly Thr Pro Gly Gly Gly Leu Pro Gln Leu Ala Leu Lys Leu Arg Leu 
            180                 185                 190         


Gln Val Leu Leu Leu Ala Arg Val Leu Arg Gly His Pro Pro Leu Leu 
        195                 200                 205             


Leu Asp Val Val Arg Asn Ala Cys Asp Leu Phe Ile Pro Leu Asp Lys 
    210                 215                 220                 


Leu Gly Leu Trp Arg Cys Gly Pro Gly Ile Val Gly Leu Cys Gly Leu 
225                 230                 235                 240 


Val Ser Ser Ile Leu Ser Ile Leu Thr Leu Ile Tyr Pro Trp Leu Arg 
                245                 250                 255     


Leu Lys Pro 
            


<210>  2913
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  2913

Met Asp Ala Phe Thr Arg Phe Thr Asn Gln Thr Gln Gly Arg Asp Arg 
1               5                   10                  15      


Leu Phe Arg Ala Thr Gln Tyr Thr Cys Met Leu Leu Arg Tyr Leu Leu 
            20                  25                  30          


Glu Pro Lys Ala Gly Lys Glu Lys Val Val Met Lys Leu Lys Lys Leu 
        35                  40                  45              


Glu Ser Ser Val Ser Thr Gly Arg Lys Trp Phe Arg Leu Gly Asn Val 
    50                  55                  60                  


Val His Ala Ile Gln Ala Thr Glu Gln Ser Ile His Ala Thr Asp Leu 
65                  70                  75                  80  


Val Pro Arg Leu Cys Leu Thr Leu Ala Asn Leu Asn Arg Val Ile Tyr 
                85                  90                  95      


Phe Ile Cys Asp Thr Ile Leu Trp Val Arg Ser Val Gly Leu Thr Ser 
            100                 105                 110         


Gly Ile Asn Lys Glu Lys Trp Arg Thr Arg Ala Ala His His Tyr Tyr 
        115                 120                 125             


Tyr Ser Leu Leu Leu Ser Leu Val Arg Asp Leu Tyr Glu Ile Ser Leu 
    130                 135                 140                 


Gln Met Lys Arg Val Thr Cys Asp Arg Ala Lys Lys Glu Lys Ser Ala 
145                 150                 155                 160 


Ser Gln Asp Pro Leu Trp Phe Ser Val Ala Glu Glu Glu Thr Glu Trp 
                165                 170                 175     


Leu Gln Ser Phe Leu Leu Leu Leu Phe Arg Ser Leu Lys Gln His Pro 
            180                 185                 190         


Pro Leu Leu Leu Asp Thr Val Lys Asn Leu Cys Asp Ile Leu Asn Pro 
        195                 200                 205             


Leu Asp Gln Leu Gly Ile Tyr Lys Ser Asn Pro Gly Ile Ile Gly Leu 
    210                 215                 220                 


Gly Gly Leu Val Ser Ser Ile Ala Gly Met Ile Thr Val Ala Tyr Pro 
225                 230                 235                 240 


Gln Met Lys Leu Lys Thr Arg 
                245         


<210>  2914
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  2914

Met Ala Gly Leu Ser Arg Gly Ser Ala Arg Ala Leu Leu Ala Ala Leu 
1               5                   10                  15      


Leu Ala Ser Thr Leu Leu Ala Leu Leu Val Ser Pro Ala Arg Gly Arg 
            20                  25                  30          


Gly Gly Arg Asp His Gly Asp Trp Asp Glu Ala Ser Arg Leu Pro Pro 
        35                  40                  45              


Leu Pro Pro Arg Glu Asp Ala Ala Arg Val Ala Arg Phe Val Thr His 
    50                  55                  60                  


Val Ser Asp Trp Gly Ala Leu Ala Thr Ile Ser Thr Leu Glu Ala Val 
65                  70                  75                  80  


Arg Gly Arg Pro Phe Ala Asp Val Leu Ser Leu Ser Asp Gly Pro Pro 
                85                  90                  95      


Gly Ala Gly Ser Gly Val Pro Tyr Phe Tyr Leu Ser Pro Leu Gln Leu 
            100                 105                 110         


Ser Val Ser Asn Leu Gln Glu Asn Pro Tyr Ala Thr Leu Thr Met Thr 
        115                 120                 125             


Leu Ala Gln Thr Asn Phe Cys Lys Lys His Gly Phe Asp Pro Gln Ser 
    130                 135                 140                 


Pro Leu Cys Val His Ile Met Leu Ser Gly Thr Val Thr Lys Val Asn 
145                 150                 155                 160 


Glu Thr Glu Met Asp Ile Ala Lys His Ser Leu Phe Ile Arg His Pro 
                165                 170                 175     


Glu Met Lys Thr Trp Pro Ser Ser His Asn Trp Phe Phe Ala Lys Leu 
            180                 185                 190         


Asn Ile Thr Asn Ile Trp Val Leu Asp Tyr Phe Gly Gly Pro Lys Ile 
        195                 200                 205             


Val Thr Pro Glu Glu Tyr Tyr Asn Val Thr Val Gln 
    210                 215                 220 


<210>  2915
<211>  599
<212>  PRT
<213>  Homo sapiens

<400>  2915

Met Leu Cys Leu Gly Trp Ile Phe Leu Trp Leu Val Ala Gly Glu Arg 
1               5                   10                  15      


Ile Lys Gly Phe Asn Ile Ser Gly Cys Ser Thr Lys Lys Leu Leu Trp 
            20                  25                  30          


Thr Tyr Ser Thr Arg Ser Glu Glu Glu Phe Val Leu Phe Cys Asp Leu 
        35                  40                  45              


Pro Glu Pro Gln Lys Ser His Phe Cys His Arg Asn Arg Leu Ser Pro 
    50                  55                  60                  


Lys Gln Val Pro Glu His Leu Pro Phe Met Gly Ser Asn Asp Leu Ser 
65                  70                  75                  80  


Asp Val Gln Trp Tyr Gln Gln Pro Ser Asn Gly Asp Pro Leu Glu Asp 
                85                  90                  95      


Ile Arg Lys Ser Tyr Pro His Ile Ile Gln Asp Lys Cys Thr Leu His 
            100                 105                 110         


Phe Leu Thr Pro Gly Val Asn Asn Ser Gly Ser Tyr Ile Cys Arg Pro 
        115                 120                 125             


Lys Met Ile Lys Ser Pro Tyr Asp Val Ala Cys Cys Val Lys Met Ile 
    130                 135                 140                 


Leu Glu Val Lys Pro Gln Thr Asn Ala Ser Cys Glu Tyr Ser Ala Ser 
145                 150                 155                 160 


His Lys Gln Asp Leu Leu Leu Gly Ser Thr Gly Ser Ile Ser Cys Pro 
                165                 170                 175     


Ser Leu Ser Cys Gln Ser Asp Ala Gln Ser Pro Ala Val Thr Trp Tyr 
            180                 185                 190         


Lys Asn Gly Lys Leu Leu Ser Val Glu Arg Ser Asn Arg Ile Val Val 
        195                 200                 205             


Asp Glu Val Tyr Asp Tyr His Gln Gly Thr Tyr Val Cys Asp Tyr Thr 
    210                 215                 220                 


Gln Ser Asp Thr Val Ser Ser Trp Thr Val Arg Ala Val Val Gln Val 
225                 230                 235                 240 


Arg Thr Ile Val Gly Asp Thr Lys Leu Lys Pro Asp Ile Leu Asp Pro 
                245                 250                 255     


Val Glu Asp Thr Leu Glu Val Glu Leu Gly Lys Pro Leu Thr Ile Ser 
            260                 265                 270         


Cys Lys Ala Arg Phe Gly Phe Glu Arg Val Phe Asn Pro Val Ile Lys 
        275                 280                 285             


Trp Tyr Ile Lys Asp Ser Asp Leu Glu Trp Glu Val Ser Val Pro Glu 
    290                 295                 300                 


Ala Lys Ser Ile Lys Ser Thr Leu Lys Asp Glu Ile Ile Glu Arg Asn 
305                 310                 315                 320 


Ile Ile Leu Glu Lys Val Thr Gln Arg Asp Leu Arg Arg Lys Phe Val 
                325                 330                 335     


Cys Phe Val Gln Asn Ser Ile Gly Asn Thr Thr Gln Ser Val Gln Leu 
            340                 345                 350         


Lys Glu Lys Arg Gly Val Val Leu Leu Tyr Ile Leu Leu Gly Thr Ile 
        355                 360                 365             


Gly Thr Leu Val Ala Val Leu Ala Ala Ser Ala Leu Leu Tyr Arg His 
    370                 375                 380                 


Trp Ile Glu Ile Val Leu Leu Tyr Arg Thr Tyr Gln Ser Lys Asp Gln 
385                 390                 395                 400 


Thr Leu Gly Asp Lys Lys Asp Phe Asp Ala Phe Val Ser Tyr Ala Lys 
                405                 410                 415     


Trp Ser Ser Phe Pro Ser Glu Ala Thr Ser Ser Leu Ser Glu Glu His 
            420                 425                 430         


Leu Ala Leu Ser Leu Phe Pro Asp Val Leu Glu Asn Lys Tyr Gly Tyr 
        435                 440                 445             


Ser Leu Cys Leu Leu Glu Arg Asp Val Ala Pro Gly Gly Val Tyr Ala 
    450                 455                 460                 


Glu Asp Ile Val Ser Ile Ile Lys Arg Ser Arg Arg Gly Ile Phe Ile 
465                 470                 475                 480 


Leu Ser Pro Asn Tyr Val Asn Gly Pro Ser Ile Phe Glu Leu Gln Ala 
                485                 490                 495     


Ala Val Asn Leu Ala Leu Asp Asp Gln Thr Leu Lys Leu Ile Leu Ile 
            500                 505                 510         


Lys Phe Cys Tyr Phe Gln Glu Pro Glu Ser Leu Pro His Leu Val Lys 
        515                 520                 525             


Lys Ala Leu Arg Val Leu Pro Thr Val Thr Trp Arg Gly Leu Lys Ser 
    530                 535                 540                 


Val Pro Pro Asn Ser Arg Phe Trp Ala Lys Met Arg Tyr His Met Pro 
545                 550                 555                 560 


Val Lys Asn Ser Gln Gly Phe Thr Trp Asn Gln Leu Arg Ile Thr Ser 
                565                 570                 575     


Arg Ile Phe Gln Trp Lys Gly Leu Ser Arg Thr Glu Thr Thr Gly Arg 
            580                 585                 590         


Ser Ser Gln Pro Lys Glu Trp 
        595                 


<210>  2916
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  2916

Met Trp Ser Leu Leu Leu Cys Gly Leu Ser Ile Ala Leu Pro Leu Ser 
1               5                   10                  15      


Val Thr Ala Asp Gly Cys Lys Asp Ile Phe Met Lys Asn Glu Ile Leu 
            20                  25                  30          


Ser Ala Ser Gln Pro Phe Ala Phe Asn Cys Thr Phe Pro Pro Ile Thr 
        35                  40                  45              


Ser Gly Glu Val Ser Val Thr Trp Tyr Lys Asn Ser Ser Lys Ile Pro 
    50                  55                  60                  


Val Ser Lys Ile Ile Gln Ser Arg Ile His Gln Asp Glu Thr Trp Ile 
65                  70                  75                  80  


Leu Phe Leu Pro Met Glu Trp Gly Asp Ser Gly Val Tyr Gln Cys Val 
                85                  90                  95      


Ile Lys Gly Arg Asp Ser Cys His Arg Ile His Val Asn Leu Thr Val 
            100                 105                 110         


Phe Glu Lys His Trp Cys Asp Thr Ser Ile Gly Gly Leu Pro Asn Leu 
        115                 120                 125             


Ser Asp Glu Tyr Lys Gln Ile Leu His Leu Gly Lys Asp Asp Ser Leu 
    130                 135                 140                 


Thr Cys His Leu His Phe Pro Lys Ser Cys Val Leu Gly Pro Ile Lys 
145                 150                 155                 160 


Trp Tyr Lys Asp Cys Asn Glu Ile Lys Gly Glu Arg Phe Thr Val Leu 
                165                 170                 175     


Glu Thr Arg Leu Leu Val Ser Asn Val Ser Ala Glu Asp Arg Gly Asn 
            180                 185                 190         


Tyr Ala Cys Gln Ala Ile Leu Thr His Ser Gly Lys Gln Tyr Glu Val 
        195                 200                 205             


Leu Asn Gly Ile Thr Val Ser Ile Thr Glu Arg Ala Gly Tyr Gly Gly 
    210                 215                 220                 


Ser Val Pro Lys Ile Ile Tyr Pro Lys Asn His Ser Ile Glu Val Gln 
225                 230                 235                 240 


Leu Gly Thr Thr Leu Ile Val Asp Cys Asn Val Thr Asp Thr Lys Asp 
                245                 250                 255     


Asn Thr Asn Leu Arg Cys Trp Arg Val Asn Asn Thr Leu Val Asp Asp 
            260                 265                 270         


Tyr Tyr Asp Glu Ser Lys Arg Ile Arg Glu Gly Val Glu Thr His Val 
        275                 280                 285             


Ser Phe Arg Glu His Asn Leu Tyr Thr Val Asn Ile Thr Phe Leu Glu 
    290                 295                 300                 


Val Lys Met Glu Asp Tyr Gly Leu Pro Phe Met Cys His Ala Gly Val 
305                 310                 315                 320 


Ser Thr Ala Tyr Ile Ile Leu Gln Leu Pro Ala Pro Asp Phe Arg Ala 
                325                 330                 335     


Tyr Leu Ile Gly Gly Leu Ile Ala Leu Val Ala Val Ala Val Ser Val 
            340                 345                 350         


Val Tyr Ile Tyr Asn Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Ser Ala Phe His Ser Thr Glu Thr Ile Val Asp Gly Lys Leu Tyr Asp 
    370                 375                 380                 


Ala Tyr Val Leu Tyr Pro Lys Pro His Lys Glu Ser Gln Arg His Ala 
385                 390                 395                 400 


Val Asp Ala Leu Val Leu Asn Ile Leu Pro Glu Val Leu Glu Arg Gln 
                405                 410                 415     


Cys Gly Tyr Lys Leu Phe Ile Phe Gly Arg Asp Glu Phe Pro Gly Gln 
            420                 425                 430         


Ala Val Ala Asn Val Ile Asp Glu Asn Val Lys Leu Cys Arg Arg Leu 
        435                 440                 445             


Ile Val Ile Val Val Pro Glu Ser Leu Gly Phe Gly Leu Leu Lys Asn 
    450                 455                 460                 


Leu Ser Glu Glu Gln Ile Ala Val Tyr Ser Ala Leu Ile Gln Asp Gly 
465                 470                 475                 480 


Met Lys Val Ile Leu Ile Glu Leu Glu Lys Ile Glu Asp Tyr Thr Val 
                485                 490                 495     


Met Pro Glu Ser Ile Gln Tyr Ile Lys Gln Lys His Gly Ala Ile Arg 
            500                 505                 510         


Trp His Gly Asp Phe Thr Glu Gln Ser Gln Cys Met Lys Thr Lys Phe 
        515                 520                 525             


Trp Lys Thr Val Arg Tyr His Met Pro Pro Arg Arg Cys Arg Pro Phe 
    530                 535                 540                 


Pro Pro Val Gln Leu Leu Gln His Thr Pro Cys Tyr Arg Thr Ala Gly 
545                 550                 555                 560 


Pro Glu Leu Gly Ser Arg Arg Lys Lys Cys Thr Leu Thr Thr Gly 
                565                 570                 575 


<210>  2917
<211>  541
<212>  PRT
<213>  Homo sapiens

<400>  2917

Met Asn Cys Arg Glu Leu Pro Leu Thr Leu Trp Val Leu Ile Ser Val 
1               5                   10                  15      


Ser Thr Ala Glu Ser Cys Thr Ser Arg Pro His Ile Thr Val Val Glu 
            20                  25                  30          


Gly Glu Pro Phe Tyr Leu Lys His Cys Ser Cys Ser Leu Ala His Glu 
        35                  40                  45              


Ile Glu Thr Thr Thr Lys Ser Trp Tyr Lys Ser Ser Gly Ser Gln Glu 
    50                  55                  60                  


His Val Glu Leu Asn Pro Arg Ser Ser Ser Arg Ile Ala Leu His Asp 
65                  70                  75                  80  


Cys Val Leu Glu Phe Trp Pro Val Glu Leu Asn Asp Thr Gly Ser Tyr 
                85                  90                  95      


Phe Phe Gln Met Lys Asn Tyr Thr Gln Lys Trp Lys Leu Asn Val Ile 
            100                 105                 110         


Arg Arg Asn Lys His Ser Cys Phe Thr Glu Arg Gln Val Thr Ser Lys 
        115                 120                 125             


Ile Val Glu Val Lys Lys Phe Phe Gln Ile Thr Cys Glu Asn Ser Tyr 
    130                 135                 140                 


Tyr Gln Thr Leu Val Asn Ser Thr Ser Leu Tyr Lys Asn Cys Lys Lys 
145                 150                 155                 160 


Leu Leu Leu Glu Asn Asn Lys Asn Pro Thr Ile Lys Lys Asn Ala Glu 
                165                 170                 175     


Phe Glu Asp Gln Gly Tyr Tyr Ser Cys Val His Phe Leu His His Asn 
            180                 185                 190         


Gly Lys Leu Phe Asn Ile Thr Lys Thr Phe Asn Ile Thr Ile Val Glu 
        195                 200                 205             


Asp Arg Ser Asn Ile Val Pro Val Leu Leu Gly Pro Lys Leu Asn His 
    210                 215                 220                 


Val Ala Val Glu Leu Gly Lys Asn Val Arg Leu Asn Cys Ser Ala Leu 
225                 230                 235                 240 


Leu Asn Glu Glu Asp Val Ile Tyr Trp Met Phe Gly Glu Glu Asn Gly 
                245                 250                 255     


Ser Asp Pro Asn Ile His Glu Glu Lys Glu Met Arg Ile Met Thr Pro 
            260                 265                 270         


Glu Gly Lys Trp His Ala Ser Lys Val Leu Arg Ile Glu Asn Ile Gly 
        275                 280                 285             


Glu Ser Asn Leu Asn Val Leu Tyr Asn Cys Thr Val Ala Ser Thr Gly 
    290                 295                 300                 


Gly Thr Asp Thr Lys Ser Phe Ile Leu Val Arg Lys Ala Asp Met Ala 
305                 310                 315                 320 


Asp Ile Pro Gly His Val Phe Thr Arg Gly Met Ile Ile Ala Val Leu 
                325                 330                 335     


Ile Leu Val Ala Val Val Cys Leu Val Thr Val Cys Val Ile Tyr Arg 
            340                 345                 350         


Val Asp Leu Val Leu Phe Tyr Arg His Leu Thr Arg Arg Asp Glu Thr 
        355                 360                 365             


Leu Thr Asp Gly Lys Thr Tyr Asp Ala Phe Val Ser Tyr Leu Lys Glu 
    370                 375                 380                 


Cys Arg Pro Glu Asn Gly Glu Glu His Thr Phe Ala Val Glu Ile Leu 
385                 390                 395                 400 


Pro Arg Val Leu Glu Lys His Phe Gly Tyr Lys Leu Cys Ile Phe Glu 
                405                 410                 415     


Arg Asp Val Val Pro Gly Gly Ala Val Val Asp Glu Ile His Ser Leu 
            420                 425                 430         


Ile Glu Lys Ser Arg Arg Leu Ile Ile Val Leu Ser Lys Ser Tyr Met 
        435                 440                 445             


Ser Asn Glu Val Arg Tyr Glu Leu Glu Ser Gly Leu His Glu Ala Leu 
    450                 455                 460                 


Val Glu Arg Lys Ile Lys Ile Ile Leu Ile Glu Phe Thr Pro Val Thr 
465                 470                 475                 480 


Asp Phe Thr Phe Leu Pro Gln Ser Leu Lys Leu Leu Lys Ser His Arg 
                485                 490                 495     


Val Leu Lys Trp Lys Ala Asp Lys Ser Leu Ser Tyr Asn Ser Arg Phe 
            500                 505                 510         


Trp Lys Asn Leu Leu Tyr Leu Met Pro Ala Lys Thr Val Lys Pro Gly 
        515                 520                 525             


Arg Asp Glu Pro Glu Val Leu Pro Val Leu Ser Glu Ser 
    530                 535                 540     


<210>  2918
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  2918

Met Gly Phe Trp Ile Leu Ala Ile Leu Thr Ile Leu Met Tyr Ser Thr 
1               5                   10                  15      


Ala Ala Lys Phe Ser Lys Gln Ser Trp Gly Leu Glu Asn Glu Ala Leu 
            20                  25                  30          


Ile Val Arg Cys Pro Arg Gln Gly Lys Pro Ser Tyr Thr Val Asp Trp 
        35                  40                  45              


Tyr Tyr Ser Gln Thr Asn Lys Ser Ile Pro Thr Gln Glu Arg Asn Arg 
    50                  55                  60                  


Val Phe Ala Ser Gly Gln Leu Leu Lys Phe Leu Pro Ala Ala Val Ala 
65                  70                  75                  80  


Asp Ser Gly Ile Tyr Thr Cys Ile Val Arg Ser Pro Thr Phe Asn Arg 
                85                  90                  95      


Thr Gly Tyr Ala Asn Val Thr Ile Tyr Lys Lys Gln Ser Asp Cys Asn 
            100                 105                 110         


Val Pro Asp Tyr Leu Met Tyr Ser Thr Val Ser Gly Ser Glu Lys Asn 
        115                 120                 125             


Ser Lys Ile Tyr Cys Pro Thr Ile Asp Leu Tyr Asn Trp Thr Ala Pro 
    130                 135                 140                 


Leu Glu Trp Phe Lys Asn Cys Gln Ala Leu Gln Gly Ser Arg Tyr Arg 
145                 150                 155                 160 


Ala His Lys Ser Phe Leu Val Ile Asp Asn Val Met Thr Glu Asp Ala 
                165                 170                 175     


Gly Asp Tyr Thr Cys Lys Phe Ile His Asn Glu Asn Gly Ala Asn Tyr 
            180                 185                 190         


Ser Val Thr Ala Thr Arg Ser Phe Thr Val Lys Asp Glu Gln Gly Phe 
        195                 200                 205             


Ser Leu Phe Pro Val Ile Gly Ala Pro Ala Gln Asn Glu Ile Lys Glu 
    210                 215                 220                 


Val Glu Ile Gly Lys Asn Ala Asn Leu Thr Cys Ser Ala Cys Phe Gly 
225                 230                 235                 240 


Lys Gly Thr Gln Phe Leu Ala Ala Val Leu Trp Gln Leu Asn Gly Thr 
                245                 250                 255     


Lys Ile Thr Asp Phe Gly Glu Pro Arg Ile Gln Gln Glu Glu Gly Gln 
            260                 265                 270         


Asn Gln Ser Phe Ser Asn Gly Leu Ala Cys Leu Asp Met Val Leu Arg 
        275                 280                 285             


Ile Ala Asp Val Lys Glu Glu Asp Leu Leu Leu Gln Tyr Asp Cys Leu 
    290                 295                 300                 


Ala Leu Asn Leu His Gly Leu Arg Arg His Thr Val Arg Leu Ser Arg 
305                 310                 315                 320 


Lys Asn Pro Ser Lys Glu Cys Phe 
                325             


<210>  2919
<211>  387
<212>  PRT
<213>  Homo sapiens

<400>  2919

Met Asn Val Ser Gly Cys Pro Gly Ala Gly Asn Ala Ser Gln Ala Gly 
1               5                   10                  15      


Gly Gly Gly Gly Trp His Pro Glu Ala Val Ile Val Pro Leu Leu Phe 
            20                  25                  30          


Ala Leu Ile Phe Leu Val Gly Thr Val Gly Asn Thr Leu Val Leu Ala 
        35                  40                  45              


Val Leu Leu Arg Gly Gly Gln Ala Val Ser Thr Thr Asn Leu Phe Ile 
    50                  55                  60                  


Leu Asn Leu Gly Val Ala Asp Leu Cys Phe Ile Leu Cys Cys Val Pro 
65                  70                  75                  80  


Phe Gln Ala Thr Ile Tyr Thr Leu Asp Gly Trp Val Phe Gly Ser Leu 
                85                  90                  95      


Leu Cys Lys Ala Val His Phe Leu Ile Phe Leu Thr Met His Ala Ser 
            100                 105                 110         


Ser Phe Thr Leu Ala Ala Val Ser Leu Asp Arg Tyr Leu Ala Ile Arg 
        115                 120                 125             


Tyr Pro Leu His Ser Arg Glu Leu Arg Thr Pro Arg Asn Ala Leu Ala 
    130                 135                 140                 


Ala Ile Gly Leu Ile Trp Gly Leu Ser Leu Leu Phe Ser Gly Pro Tyr 
145                 150                 155                 160 


Leu Ser Tyr Tyr Arg Gln Ser Gln Leu Ala Asn Leu Thr Val Cys His 
                165                 170                 175     


Pro Ala Trp Ser Ala Pro Arg Arg Arg Ala Met Asp Ile Cys Thr Phe 
            180                 185                 190         


Val Phe Ser Tyr Leu Leu Pro Val Leu Val Leu Gly Leu Thr Tyr Ala 
        195                 200                 205             


Arg Thr Leu Arg Tyr Leu Trp Arg Ala Val Asp Pro Val Ala Ala Gly 
    210                 215                 220                 


Ser Gly Ala Arg Arg Ala Lys Arg Lys Val Thr Arg Met Ile Leu Ile 
225                 230                 235                 240 


Val Ala Ala Leu Phe Cys Leu Cys Trp Met Pro His His Ala Leu Ile 
                245                 250                 255     


Leu Cys Val Trp Phe Gly Gln Phe Pro Leu Thr Arg Ala Thr Tyr Ala 
            260                 265                 270         


Leu Arg Ile Leu Ser His Leu Val Ser Tyr Ala Asn Ser Cys Val Asn 
        275                 280                 285             


Pro Ile Val Tyr Ala Leu Val Ser Lys His Phe Arg Lys Gly Phe Arg 
    290                 295                 300                 


Thr Ile Cys Ala Gly Leu Leu Gly Arg Ala Pro Gly Arg Ala Ser Gly 
305                 310                 315                 320 


Arg Val Cys Ala Ala Ala Arg Gly Thr His Ser Gly Ser Val Leu Glu 
                325                 330                 335     


Arg Glu Ser Ser Asp Leu Leu His Met Ser Glu Ala Ala Gly Ala Leu 
            340                 345                 350         


Arg Pro Cys Pro Gly Ala Ser Gln Pro Cys Ile Leu Glu Pro Cys Pro 
        355                 360                 365             


Gly Pro Ser Trp Gln Gly Pro Lys Ala Gly Asp Ser Ile Leu Thr Val 
    370                 375                 380                 


Asp Val Ala 
385         


<210>  2920
<211>  84
<212>  PRT
<213>  Homo sapiens

<400>  2920

Met Ala Thr Gly Thr Asp Gln Val Val Gly Leu Gly Leu Val Ala Val 
1               5                   10                  15      


Ser Leu Ile Ile Phe Thr Tyr Tyr Thr Ala Trp Val Ile Leu Leu Pro 
            20                  25                  30          


Phe Ile Asp Ser Gln His Val Ile His Lys Tyr Phe Leu Pro Arg Ala 
        35                  40                  45              


Tyr Ala Val Ala Ile Pro Leu Ala Ala Gly Leu Leu Leu Leu Leu Phe 
    50                  55                  60                  


Val Gly Leu Phe Ile Ser Tyr Val Met Leu Lys Thr Lys Arg Val Thr 
65                  70                  75                  80  


Lys Lys Ala Gln 
                


<210>  2921
<211>  924
<212>  PRT
<213>  Homo sapiens

<400>  2921

Met Glu Ile Lys Glu Glu Gly Ala Ser Glu Glu Gly Gln His Phe Leu 
1               5                   10                  15      


Pro Thr Ala Gln Ala Asn Asp Pro Gly Asp Cys Gln Phe Thr Ser Ile 
            20                  25                  30          


Gln Lys Thr Pro Asn Glu Pro Gln Leu Glu Phe Ile Leu Ala Cys Lys 
        35                  40                  45              


Asp Leu Val Ala Pro Val Arg Asp Arg Lys Leu Asn Thr Leu Val Gln 
    50                  55                  60                  


Ile Ser Val Ile His Pro Val Glu Gln Ser Leu Thr Arg Tyr Ser Ser 
65                  70                  75                  80  


Thr Glu Ile Val Glu Gly Thr Arg Asp Pro Leu Phe Leu Thr Gly Val 
                85                  90                  95      


Thr Phe Pro Ser Glu Tyr Pro Ile Tyr Glu Glu Thr Lys Ile Lys Leu 
            100                 105                 110         


Thr Val Tyr Asp Val Lys Asp Lys Ser His Asp Thr Val Arg Thr Ser 
        115                 120                 125             


Val Leu Pro Glu His Lys Asp Pro Pro Pro Glu Val Gly Arg Ser Phe 
    130                 135                 140                 


Leu Gly Tyr Ala Ser Phe Lys Val Gly Glu Leu Leu Lys Ser Lys Glu 
145                 150                 155                 160 


Gln Leu Leu Val Leu Ser Leu Arg Thr Ser Asp Gly Gly Lys Val Val 
                165                 170                 175     


Gly Thr Ile Glu Val Ser Val Val Lys Met Gly Glu Ile Glu Asp Gly 
            180                 185                 190         


Glu Ala Asp His Ile Thr Thr Asp Val Gln Gly Gln Lys Cys Ala Leu 
        195                 200                 205             


Val Cys Glu Cys Thr Ala Pro Glu Ser Val Ser Gly Lys Asp Asn Leu 
    210                 215                 220                 


Pro Phe Leu Asn Ser Val Leu Lys Asn Pro Val Cys Lys Leu Tyr Arg 
225                 230                 235                 240 


Phe Pro Thr Ser Asp Asn Lys Trp Met Arg Ile Arg Glu Gln Met Ser 
                245                 250                 255     


Glu Ser Ile Leu Ser Phe His Ile Pro Lys Glu Leu Ile Ser Leu His 
            260                 265                 270         


Ile Lys Glu Asp Leu Cys Arg Asn Gln Glu Ile Lys Glu Leu Gly Glu 
        275                 280                 285             


Leu Ser Pro His Trp Asp Asn Leu Arg Lys Asn Val Leu Thr His Cys 
    290                 295                 300                 


Asp Gln Met Val Asn Met Tyr Gln Asp Ile Leu Thr Glu Leu Ser Lys 
305                 310                 315                 320 


Glu Thr Gly Ser Ser Phe Lys Ser Ser Ser Ser Lys Gly Glu Lys Thr 
                325                 330                 335     


Leu Glu Phe Val Pro Ile Asn Leu His Leu Gln Arg Met Gln Val His 
            340                 345                 350         


Ser Pro His Leu Lys Asp Ala Leu Tyr Asp Val Ile Thr Val Gly Ala 
        355                 360                 365             


Pro Ala Ala His Phe Gln Gly Phe Lys Asn Gly Gly Leu Arg Lys Leu 
    370                 375                 380                 


Leu His Arg Phe Glu Thr Glu Arg Arg Asn Thr Gly Tyr Gln Phe Ile 
385                 390                 395                 400 


Tyr Tyr Ser Pro Glu Asn Thr Ala Lys Ala Lys Glu Val Leu Ser Asn 
                405                 410                 415     


Ile Asn Gln Leu Gln Pro Leu Ile Ala Thr His Ala Asp Leu Leu Leu 
            420                 425                 430         


Asn Ser Ala Ser Gln His Ser Pro Asp Ser Leu Lys Asn Ser Leu Lys 
        435                 440                 445             


Met Leu Ser Glu Lys Thr Glu Leu Phe Val His Ala Phe Lys Asp Gln 
    450                 455                 460                 


Leu Val Arg Ser Ala Leu Leu Ala Leu Tyr Thr Ala Arg Pro Gly Gly 
465                 470                 475                 480 


Ile Leu Lys Lys Pro Pro Ser Pro Lys Ser Ser Thr Glu Glu Ser Ser 
                485                 490                 495     


Pro Gln Asp Gln Pro Pro Val Met Arg Gly Gln Asp Ser Ile Pro His 
            500                 505                 510         


His Ser Asp Tyr Asp Glu Glu Glu Trp Asp Arg Val Trp Ala Asn Val 
        515                 520                 525             


Gly Lys Ser Leu Asn Cys Ile Ile Ala Met Val Asp Lys Leu Ile Glu 
    530                 535                 540                 


Arg Asp Gly Gly Ser Glu Gly Ser Gly Gly Asn Asn Asp Gly Glu Lys 
545                 550                 555                 560 


Glu Pro Ser Leu Thr Asp Ala Ile Pro Ser His Pro Arg Glu Asp Trp 
                565                 570                 575     


Tyr Glu Gln Leu Tyr Pro Leu Ile Leu Thr Leu Lys Asp Cys Met Gly 
            580                 585                 590         


Glu Val Val Asn Arg Ala Lys Gln Ser Leu Thr Phe Val Leu Leu Gln 
        595                 600                 605             


Glu Leu Ala Tyr Ser Leu Pro Gln Cys Leu Met Leu Thr Leu Arg Arg 
    610                 615                 620                 


Asp Ile Val Phe Ser Gln Ala Leu Ala Gly Leu Val Cys Gly Phe Ile 
625                 630                 635                 640 


Ile Lys Leu Gln Thr Ser Leu Tyr Asp Pro Gly Phe Leu Gln Gln Leu 
                645                 650                 655     


His Thr Val Gly Leu Ile Val Gln Tyr Glu Gly Leu Leu Ser Thr Tyr 
            660                 665                 670         


Ser Asp Glu Ile Gly Met Leu Glu Asp Met Ala Val Gly Ile Ser Asp 
        675                 680                 685             


Leu Lys Lys Val Ala Phe Lys Ile Ile Glu Ala Lys Ser Asn Asp Val 
    690                 695                 700                 


Leu Pro Val Ile Thr Gly Arg Arg Glu His Tyr Val Val Glu Val Lys 
705                 710                 715                 720 


Leu Pro Ala Arg Met Phe Glu Ser Leu Pro Leu Gln Ile Lys Glu Gly 
                725                 730                 735     


Gln Leu Leu His Val Tyr Pro Val Leu Phe Asn Val Gly Ile Asn Glu 
            740                 745                 750         


Gln Gln Thr Leu Ala Glu Arg Phe Gly Asp Val Ser Leu Gln Glu Ser 
        755                 760                 765             


Ile Asn Gln Glu Asn Phe Glu Leu Leu Gln Glu Tyr Tyr Lys Ile Phe 
    770                 775                 780                 


Met Glu Lys Met Pro Pro Asp Tyr Ile Ser His Phe Gln Glu Gln Asn 
785                 790                 795                 800 


Asp Leu Lys Ala Leu Leu Glu Asn Leu Leu Gln Asn Ile Gln Ser Lys 
                805                 810                 815     


Lys Arg Lys Asn Val Glu Ile Met Trp Leu Ala Ala Thr Ile Cys Arg 
            820                 825                 830         


Lys Leu Asn Gly Ile Arg Phe Thr Cys Cys Lys Ser Ala Lys Asp Arg 
        835                 840                 845             


Thr Ser Met Ser Val Thr Leu Glu Gln Cys Ser Ile Leu Arg Asp Glu 
    850                 855                 860                 


His Gln Leu His Lys Asp Phe Phe Ile Arg Ala Leu Asp Cys Met Arg 
865                 870                 875                 880 


Arg Glu Gly Cys Arg Ile Glu Asn Val Leu Lys Asn Ile Lys Cys Arg 
                885                 890                 895     


Lys Tyr Ala Phe Asn Met Leu Gln Leu Met Ala Phe Pro Lys Tyr Tyr 
            900                 905                 910         


Arg Pro Pro Glu Gly Thr Tyr Gly Lys Ala Asp Thr 
        915                 920                 


<210>  2922
<211>  926
<212>  PRT
<213>  Homo sapiens

<400>  2922

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Val Asp Ile Pro Glu Ile His Glu 
                805                 810                 815     


Arg Glu Gly Tyr Glu Asp Glu Ile Asp Asp Glu Tyr Glu Val Asp Trp 
            820                 825                 830         


Ser Asn Ser Ser Ser Ala Thr Ser Gly Ser Gly Ala Pro Ser Thr Asp 
        835                 840                 845             


Lys Glu Lys Ser Trp Leu Tyr Thr Leu Asp Pro Ile Leu Ile Thr Ile 
    850                 855                 860                 


Ile Ala Met Ser Ser Leu Gly Val Leu Leu Gly Ala Thr Cys Ala Gly 
865                 870                 875                 880 


Leu Leu Leu Tyr Cys Thr Cys Ser Tyr Ser Gly Leu Ser Ser Arg Ser 
                885                 890                 895     


Cys Thr Thr Leu Glu Asn Tyr Asn Phe Glu Leu Tyr Asp Gly Leu Lys 
            900                 905                 910         


His Lys Val Lys Met Asn His Gln Lys Cys Cys Ser Glu Ala 
        915                 920                 925     


<210>  2923
<211>  923
<212>  PRT
<213>  Homo sapiens

<400>  2923

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln Leu Lys 
            660                 665                 670         


Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp 
                805                 810                 815     


Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly 
            820                 825                 830         


Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly 
        835                 840                 845             


Asn Val Leu Lys Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met 
    850                 855                 860                 


Ser Ala Leu Gly Val Leu Leu Gly Ala Val Cys Gly Val Val Leu Tyr 
865                 870                 875                 880 


Cys Ala Cys Trp His Asn Gly Met Ser Glu Arg Asn Leu Ser Ala Leu 
                885                 890                 895     


Glu Asn Tyr Asn Phe Glu Leu Val Asp Gly Val Lys Leu Lys Lys Asp 
            900                 905                 910         


Lys Leu Asn Thr Gln Ser Thr Tyr Ser Glu Ala 
        915                 920             


<210>  2924
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  2924

Met Ala Gln His His Leu Trp Ile Leu Leu Leu Cys Leu Gln Thr Trp 
1               5                   10                  15      


Pro Glu Ala Ala Gly Lys Asp Ser Glu Ile Phe Thr Val Asn Gly Ile 
            20                  25                  30          


Leu Gly Glu Ser Val Thr Phe Pro Val Asn Ile Gln Glu Pro Arg Gln 
        35                  40                  45              


Val Lys Ile Ile Ala Trp Thr Ser Lys Thr Ser Val Ala Tyr Val Thr 
    50                  55                  60                  


Pro Gly Asp Ser Glu Thr Ala Pro Val Val Thr Val Thr His Arg Asn 
65                  70                  75                  80  


Tyr Tyr Glu Arg Ile His Ala Leu Gly Pro Asn Tyr Asn Leu Val Ile 
                85                  90                  95      


Ser Asp Leu Arg Met Glu Asp Ala Gly Asp Tyr Lys Ala Asp Ile Asn 
            100                 105                 110         


Thr Gln Ala Asp Pro Tyr Thr Thr Thr Lys Arg Tyr Asn Leu Gln Ile 
        115                 120                 125             


Tyr Arg Arg Leu Gly Lys Pro Lys Ile Thr Gln Ser Leu Met Ala Ser 
    130                 135                 140                 


Val Asn Ser Thr Cys Asn Val Thr Leu Thr Cys Ser Val Glu Lys Glu 
145                 150                 155                 160 


Glu Lys Asn Val Thr Tyr Asn Trp Ser Pro Leu Gly Glu Glu Gly Asn 
                165                 170                 175     


Val Leu Gln Ile Phe Gln Thr Pro Glu Asp Gln Glu Leu Thr Tyr Thr 
            180                 185                 190         


Cys Thr Ala Gln Asn Pro Val Ser Asn Asn Ser Asp Ser Ile Ser Ala 
        195                 200                 205             


Arg Gln Leu Cys Ala Asp Ile Ala Met Gly Phe Arg Thr His His Thr 
    210                 215                 220                 


Gly Leu Leu Ser Val Leu Ala Met Phe Phe Leu Leu Val Leu Ile Leu 
225                 230                 235                 240 


Ser Ser Val Phe Leu Phe Arg Leu Phe Lys Arg Arg Gln Asp Ala Ala 
                245                 250                 255     


Ser Lys Lys Thr Ile Tyr Thr Tyr Ile Met Ala Ser Arg Asn Thr Gln 
            260                 265                 270         


Pro Ala Glu Ser Arg Ile Tyr Asp Glu Ile Leu Gln Ser Lys Val Leu 
        275                 280                 285             


Pro Ser Lys Glu Glu Pro Val Asn Thr Val Tyr Ser Glu Val Gln Phe 
    290                 295                 300                 


Ala Asp Lys Met Gly Lys Ala Ser Thr Gln Asp Ser Lys Pro Pro Gly 
305                 310                 315                 320 


Thr Ser Ser Tyr Glu Ile Val Ile 
                325             


<210>  2925
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  2925

Met Arg Thr Lys Ala Ala Gly Cys Ala Glu Arg Arg Pro Leu Gln Pro 
1               5                   10                  15      


Arg Thr Glu Ala Ala Ala Ala Pro Ala Gly Arg Ala Met Pro Ser Glu 
            20                  25                  30          


Tyr Thr Tyr Val Lys Leu Arg Ser Asp Cys Ser Arg Pro Ser Leu Gln 
        35                  40                  45              


Trp Tyr Thr Arg Ala Gln Ser Lys Met Arg Arg Pro Ser Leu Leu Leu 
    50                  55                  60                  


Lys Asp Ile Leu Lys Cys Thr Leu Leu Val Phe Gly Val Trp Ile Leu 
65                  70                  75                  80  


Tyr Ile Leu Lys Leu Asn Tyr Thr Thr Glu Glu Cys Asp Met Lys Lys 
                85                  90                  95      


Met His Tyr Val Asp Pro Asp His Val Lys Arg Ala Gln Lys Tyr Ala 
            100                 105                 110         


Gln Gln Val Leu Gln Lys Glu Cys Arg Pro Lys Phe Ala Lys Thr Ser 
        115                 120                 125             


Met Ala Leu Leu Phe Glu His Arg Tyr Ser Val Asp Leu Leu Pro Phe 
    130                 135                 140                 


Val Gln Lys Ala Pro Lys Asp Ser Glu Ala Glu Ser Lys Tyr Asp Pro 
145                 150                 155                 160 


Pro Phe Gly Phe Arg Lys Phe Ser Ser Lys Val Gln Thr Leu Leu Glu 
                165                 170                 175     


Leu Leu Pro Glu His Asp Leu Pro Glu His Leu Lys Ala Lys Thr Cys 
            180                 185                 190         


Arg Arg Cys Val Val Ile Gly Ser Gly Gly Ile Leu His Gly Leu Glu 
        195                 200                 205             


Leu Gly His Thr Leu Asn Gln Phe Asp Val Val Ile Arg Leu Asn Ser 
    210                 215                 220                 


Ala Pro Val Glu Gly Tyr Ser Glu His Val Gly Asn Lys Thr Thr Ile 
225                 230                 235                 240 


Arg Met Thr Tyr Pro Glu Gly Ala Pro Leu Ser Asp Leu Glu Tyr Tyr 
                245                 250                 255     


Ser Asn Asp Leu Phe Val Ala Val Leu Phe Lys Ser Val Asp Phe Asn 
            260                 265                 270         


Trp Leu Gln Ala Met Val Lys Lys Glu Thr Leu Pro Phe Trp Val Arg 
        275                 280                 285             


Leu Phe Phe Trp Lys Gln Val Ala Glu Lys Ile Pro Leu Gln Pro Lys 
    290                 295                 300                 


His Phe Arg Ile Leu Asn Pro Val Ile Ile Lys Glu Thr Ala Phe Asp 
305                 310                 315                 320 


Ile Leu Gln Tyr Ser Glu Pro Gln Ser Arg Phe Trp Gly Arg Asp Lys 
                325                 330                 335     


Asn Val Pro Thr Ile Gly Val Ile Ala Val Val Leu Ala Thr His Leu 
            340                 345                 350         


Cys Asp Glu Val Ser Leu Ala Gly Phe Gly Tyr Asp Leu Asn Gln Pro 
        355                 360                 365             


Arg Thr Pro Leu His Tyr Phe Asp Ser Gln Cys Met Ala Ala Met Asn 
    370                 375                 380                 


Phe Gln Thr Met His Asn Val Thr Thr Glu Thr Lys Phe Leu Leu Lys 
385                 390                 395                 400 


Leu Val Lys Glu Gly Val Val Lys Asp Leu Ser Gly Gly Ile Asp Arg 
                405                 410                 415     


Glu Phe 
        


<210>  2926
<211>  568
<212>  PRT
<213>  Homo sapiens

<400>  2926

Met Pro Ser Thr Asp Leu Leu Met Leu Lys Ala Phe Glu Pro Tyr Leu 
1               5                   10                  15      


Glu Ile Leu Glu Val Tyr Ser Thr Lys Ala Lys Asn Tyr Val Asn Gly 
            20                  25                  30          


His Cys Thr Lys Tyr Glu Pro Trp Gln Leu Ile Ala Trp Ser Val Val 
        35                  40                  45              


Trp Thr Leu Leu Ile Val Trp Gly Tyr Glu Phe Val Phe Gln Pro Glu 
    50                  55                  60                  


Ser Leu Trp Ser Arg Phe Lys Lys Lys Cys Phe Lys Leu Thr Arg Lys 
65                  70                  75                  80  


Met Pro Ile Ile Gly Arg Lys Ile Gln Asp Lys Leu Asn Lys Thr Lys 
                85                  90                  95      


Asp Asp Ile Ser Lys Asn Met Ser Phe Leu Lys Val Asp Lys Glu Tyr 
            100                 105                 110         


Val Lys Ala Leu Pro Ser Gln Gly Leu Ser Ser Ser Ala Val Leu Glu 
        115                 120                 125             


Lys Leu Lys Glu Tyr Ser Ser Met Asp Ala Phe Trp Gln Glu Gly Arg 
    130                 135                 140                 


Ala Ser Gly Thr Val Tyr Ser Gly Glu Glu Lys Leu Thr Glu Leu Leu 
145                 150                 155                 160 


Val Lys Ala Tyr Gly Asp Phe Ala Trp Ser Asn Pro Leu His Pro Asp 
                165                 170                 175     


Ile Phe Pro Gly Leu Arg Lys Ile Glu Ala Glu Ile Val Arg Ile Ala 
            180                 185                 190         


Cys Ser Leu Phe Asn Gly Gly Pro Asp Ser Cys Gly Cys Val Thr Ser 
        195                 200                 205             


Gly Gly Thr Glu Ser Ile Leu Met Ala Cys Lys Ala Tyr Arg Asp Leu 
    210                 215                 220                 


Ala Phe Glu Lys Gly Ile Lys Thr Pro Glu Ile Val Ala Pro Gln Ser 
225                 230                 235                 240 


Ala His Ala Ala Phe Asn Lys Ala Ala Ser Tyr Phe Gly Met Lys Ile 
                245                 250                 255     


Val Arg Val Pro Leu Thr Lys Met Met Glu Val Asp Val Arg Ala Met 
            260                 265                 270         


Arg Arg Ala Ile Ser Arg Asn Thr Ala Met Leu Val Cys Ser Thr Pro 
        275                 280                 285             


Gln Phe Pro His Gly Val Ile Asp Pro Val Pro Glu Val Ala Lys Leu 
    290                 295                 300                 


Ala Val Lys Tyr Lys Ile Pro Leu His Val Asp Ala Cys Leu Gly Gly 
305                 310                 315                 320 


Phe Leu Ile Val Phe Met Glu Lys Ala Gly Tyr Pro Leu Glu His Pro 
                325                 330                 335     


Phe Asp Phe Arg Val Lys Gly Val Thr Ser Ile Ser Ala Asp Thr His 
            340                 345                 350         


Lys Tyr Gly Tyr Ala Pro Lys Gly Ser Ser Leu Val Leu Tyr Ser Asp 
        355                 360                 365             


Lys Lys Tyr Arg Asn Tyr Gln Phe Phe Val Asp Thr Asp Trp Gln Gly 
    370                 375                 380                 


Gly Ile Tyr Ala Ser Pro Thr Ile Ala Gly Ser Arg Pro Gly Gly Ile 
385                 390                 395                 400 


Ser Ala Ala Cys Trp Ala Ala Leu Met His Phe Gly Glu Asn Gly Tyr 
                405                 410                 415     


Val Glu Ala Thr Lys Gln Ile Ile Lys Thr Ala Arg Phe Leu Lys Ser 
            420                 425                 430         


Glu Leu Glu Asn Ile Lys Gly Ile Phe Val Phe Gly Asn Pro Gln Leu 
        435                 440                 445             


Ser Val Ile Ala Leu Gly Ser Arg Asp Phe Asp Ile Tyr Arg Leu Ser 
    450                 455                 460                 


Asn Leu Met Thr Ala Lys Gly Trp Asn Leu Asn Gln Leu Gln Phe Pro 
465                 470                 475                 480 


Pro Ser Ile His Phe Cys Ile Thr Leu Leu His Ala Arg Lys Arg Val 
                485                 490                 495     


Ala Ile Gln Phe Leu Lys Asp Ile Arg Glu Ser Val Thr Gln Ile Met 
            500                 505                 510         


Lys Asn Pro Lys Ala Lys Thr Thr Gly Met Gly Ala Ile Tyr Gly Met 
        515                 520                 525             


Ala Gln Thr Thr Val Asp Arg Asn Met Val Ala Glu Leu Ser Ser Val 
    530                 535                 540                 


Phe Leu Asp Ser Leu Tyr Ser Thr Asp Thr Val Thr Gln Gly Ser Gln 
545                 550                 555                 560 


Met Asn Gly Ser Pro Lys Pro His 
                565             


<210>  2927
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  2927

Met Gln Leu Pro Arg Trp Trp Glu Leu Gly Asp Pro Cys Ala Trp Thr 
1               5                   10                  15      


Gly Gln Gly Arg Gly Thr Arg Arg Met Ser Pro Ala Thr Thr Gly Thr 
            20                  25                  30          


Phe Leu Leu Thr Val Tyr Ser Ile Phe Ser Lys Val His Ser Asp Arg 
        35                  40                  45              


Asn Val Tyr Pro Ser Ala Gly Val Leu Phe Val His Val Leu Glu Arg 
    50                  55                  60                  


Glu Tyr Phe Lys Gly Glu Phe Pro Pro Tyr Pro Lys Pro Gly Glu Ile 
65                  70                  75                  80  


Ser Asn Asp Pro Ile Thr Phe Asn Thr Asn Leu Met Gly Tyr Pro Asp 
                85                  90                  95      


Arg Pro Gly Trp Leu Arg Tyr Ile Gln Arg Thr Pro Tyr Ser Asp Gly 
            100                 105                 110         


Val Leu Tyr Gly Ser Pro Thr Ala Glu Asn Val Gly Lys Pro Thr Ile 
        115                 120                 125             


Ile Glu Ile Thr Ala Tyr Asn Arg Arg Thr Phe Glu Thr Ala Arg His 
    130                 135                 140                 


Asn Leu Ile Ile Asn Ile Met Ser Ala Glu Asp Phe Pro Leu Pro Tyr 
145                 150                 155                 160 


Gln Ala Glu Phe Phe Ile Lys Asn Met Asn Val Glu Glu Met Leu Ala 
                165                 170                 175     


Ser Glu Val Leu Gly Asp Phe Leu Gly Ala Val Lys Asn Val Trp Gln 
            180                 185                 190         


Pro Glu Arg Leu Asn Ala Ile Asn Ile Thr Ser Ala Leu Asp Arg Gly 
        195                 200                 205             


Gly Arg Val Pro Leu Pro Ile Asn Asp Leu Lys Glu Gly Val Tyr Val 
    210                 215                 220                 


Met Val Gly Ala Asp Val Pro Phe Ser Ser Cys Leu Arg Glu Val Glu 
225                 230                 235                 240 


Asn Pro Gln Asn Gln Leu Arg Cys Ser Gln Glu Met Glu Pro Val Ile 
                245                 250                 255     


Thr Cys Asp Lys Lys Phe Arg Thr Gln Phe Tyr Ile Asp Trp Cys Lys 
            260                 265                 270         


Ile Ser Leu Val Asp Lys Thr Lys Gln Val Ser Thr Tyr Gln Glu Val 
        275                 280                 285             


Ile Arg Gly Glu Gly Ile Leu Pro Asp Gly Gly Glu Tyr Lys Pro Pro 
    290                 295                 300                 


Ser Asp Ser Leu Lys Ser Arg Asp Tyr Tyr Thr Asp Phe Leu Ile Thr 
305                 310                 315                 320 


Leu Ala Val Pro Ser Ala Val Ala Leu Val Leu Phe Leu Ile Leu Ala 
                325                 330                 335     


Tyr Ile Met Cys Cys Arg Arg Glu Gly Val Glu Lys Arg Asn Met Gln 
            340                 345                 350         


Thr Pro Asp Ile Gln Leu Val His His Ser Ala Ile Gln Lys Ser Thr 
        355                 360                 365             


Lys Glu Leu Arg Asp Met Ser Lys Asn Arg Glu Ile Ala Trp Pro Leu 
    370                 375                 380                 


Ser Thr Leu Pro Val Phe His Pro Val Thr Gly Glu Ile Ile Pro Pro 
385                 390                 395                 400 


Leu His Thr Asp Asn Tyr Asp Ser Thr Asn Met Pro Leu Met Gln Thr 
                405                 410                 415     


Gln Gln Asn Leu Pro His Gln Thr Gln Ile Pro Gln Gln Gln Thr Thr 
            420                 425                 430         


Gly Lys Trp Tyr Pro 
        435         


<210>  2928
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  2928

Met Ala Tyr His Gly Leu Thr Val Pro Leu Ile Val Met Ser Val Phe 
1               5                   10                  15      


Trp Gly Phe Val Gly Phe Leu Val Pro Trp Phe Ile Pro Lys Gly Pro 
            20                  25                  30          


Asn Arg Gly Val Ile Ile Thr Met Leu Val Thr Cys Ser Val Cys Cys 
        35                  40                  45              


Tyr Leu Phe Trp Leu Ile Ala Ile Leu Ala Gln Leu Asn Pro Leu Phe 
    50                  55                  60                  


Gly Pro Gln Leu Lys Asn Glu Thr Ile Trp Tyr Leu Lys Tyr His Trp 
65                  70                  75                  80  


Pro 
    


<210>  2929
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  2929

Met Ala Ala Ser Ala Gly Ala Gly Ala Val Ile Ala Ala Pro Asp Ser 
1               5                   10                  15      


Arg Arg Trp Leu Trp Ser Val Leu Ala Ala Ala Leu Gly Leu Leu Thr 
            20                  25                  30          


Ala Gly Val Ser Ala Leu Glu Val Tyr Thr Pro Lys Glu Ile Phe Val 
        35                  40                  45              


Ala Asn Gly Thr Gln Gly Lys Leu Thr Cys Lys Phe Lys Ser Thr Ser 
    50                  55                  60                  


Thr Thr Gly Gly Leu Thr Ser Val Ser Trp Ser Phe Gln Pro Glu Gly 
65                  70                  75                  80  


Ala Asp Thr Thr Val Ser Phe Phe His Tyr Ser Gln Gly Gln Val Tyr 
                85                  90                  95      


Leu Gly Asn Tyr Pro Pro Phe Lys Asp Arg Ile Ser Trp Ala Gly Asp 
            100                 105                 110         


Leu Asp Lys Lys Asp Ala Ser Ile Asn Ile Glu Asn Met Gln Phe Ile 
        115                 120                 125             


His Asn Gly Thr Tyr Ile Cys Asp Val Lys Asn Pro Pro Asp Ile Val 
    130                 135                 140                 


Val Gln Pro Gly His Ile Arg Leu Tyr Val Val Glu Lys Glu Asn Leu 
145                 150                 155                 160 


Pro Val Phe Pro Val Trp Val Val Val Gly Ile Val Thr Ala Val Val 
                165                 170                 175     


Leu Gly Leu Thr Leu Leu Ile Ser Met Ile Leu Ala Val Leu Tyr Arg 
            180                 185                 190         


Arg Lys Asn Ser Lys Arg Asp Tyr Thr Gly Cys Ser Thr Ser Glu Ser 
        195                 200                 205             


Leu Ser Pro Val Lys Gln Ala Pro Arg Lys Ser Pro Ser Asp Thr Glu 
    210                 215                 220                 


Gly Leu Val Lys Ser Leu Pro Ser Gly Ser His Gln Gly Pro Val Ile 
225                 230                 235                 240 


Tyr Ala Gln Leu Asp His Ser Gly Gly His His Ser Asp Lys Ile Asn 
                245                 250                 255     


Lys Ser Glu Ser Val Val Tyr Ala Asp Ile Arg Lys Asn 
            260                 265                 


<210>  2930
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  2930

Met Ala Pro Cys His Ile Arg Lys Tyr Gln Glu Ser Asp Arg Gln Trp 
1               5                   10                  15      


Val Val Gly Leu Leu Ser Arg Gly Met Ala Glu His Ala Pro Ala Thr 
            20                  25                  30          


Phe Arg Gln Leu Leu Lys Leu Pro Arg Thr Leu Ile Leu Leu Leu Gly 
        35                  40                  45              


Gly Pro Leu Ala Leu Leu Leu Val Ser Gly Ser Trp Leu Leu Ala Leu 
    50                  55                  60                  


Val Phe Ser Ile Ser Leu Phe Pro Ala Leu Trp Phe Leu Ala Lys Lys 
65                  70                  75                  80  


Pro Trp Thr Glu Tyr Val Asp Met Thr Leu Cys Thr Asp Met Ser Asp 
                85                  90                  95      


Ile Thr Lys Ser Tyr Leu Ser Glu Arg Gly Ser Cys Phe Trp Val Ala 
            100                 105                 110         


Glu Ser Glu Glu Lys Val Val Gly Met Val Gly Ala Leu Pro Val Asp 
        115                 120                 125             


Asp Pro Thr Leu Arg Glu Lys Arg Leu Gln Leu Phe His Leu Phe Val 
    130                 135                 140                 


Asp Ser Glu His Arg Arg Gln Gly Ile Ala Lys Ala Leu Val Arg Thr 
145                 150                 155                 160 


Val Leu Gln Phe Ala Arg Asp Gln Gly Tyr Ser Glu Val Ile Leu Asp 
                165                 170                 175     


Thr Gly Thr Ile Gln Leu Ser Ala Met Ala Leu Tyr Gln Ser Met Gly 
            180                 185                 190         


Phe Lys Lys Thr Gly Gln Ser Phe Phe Cys Val Trp Ala Arg Leu Val 
        195                 200                 205             


Ala Leu His Thr Val His Phe Ile Tyr His Leu Pro Ser Ser Lys Val 
    210                 215                 220                 


Gly Ser Leu 
225         


<210>  2931
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  2931

Met Asp Arg Ser Ser Leu Leu Gln Leu Ile Gln Glu Gln Gln Leu Asp 
1               5                   10                  15      


Pro Glu Asn Thr Gly Phe Ile Gly Ala Asp Thr Phe Thr Gly Leu Val 
            20                  25                  30          


His Ser His Glu Leu Pro Leu Asp Pro Ala Lys Leu Asp Met Leu Val 
        35                  40                  45              


Ala Leu Ala Gln Ser Asn Glu Gln Gly Gln Val Cys Tyr Gln Glu Leu 
    50                  55                  60                  


Val Asp Leu Ile Ser Ser Lys Arg Ser Ser Ser Phe Lys Arg Ala Ile 
65                  70                  75                  80  


Ala Asn Gly Gln Arg Ala Leu Pro Arg Asp Gly Pro Leu Asp Glu Pro 
                85                  90                  95      


Gly Leu Gly Val Tyr Lys Arg Phe Val Arg Tyr Val Ala Tyr Glu Ile 
            100                 105                 110         


Leu Pro Cys Glu Val Asp Arg Arg Trp Tyr Phe Tyr Arg His Arg Ser 
        115                 120                 125             


Cys Pro Pro Pro Val Phe Met Ala Ser Val Thr Leu Ala Gln Ile Ile 
    130                 135                 140                 


Val Phe Leu Cys Tyr Gly Ala Arg Leu Asn Lys Trp Val Leu Gln Thr 
145                 150                 155                 160 


Tyr His Pro Glu Tyr Met Lys Ser Pro Leu Val Tyr His Pro Gly His 
                165                 170                 175     


Arg Ala Arg Ala Trp Arg Phe Leu Thr Tyr Met Phe Met His Val Gly 
            180                 185                 190         


Leu Glu Gln Leu Gly Phe Asn Ala Leu Leu Gln Leu Met Ile Gly Val 
        195                 200                 205             


Pro Leu Glu Met Val His Gly Leu Leu Arg Ile Ser Leu Leu Tyr Leu 
    210                 215                 220                 


Ala Gly Val Leu Ala Gly Ser Leu Thr Val Ser Ile Thr Asp Met Arg 
225                 230                 235                 240 


Ala Pro Val Val Gly Gly Ser Gly Gly Val Tyr Ala Leu Cys Ser Ala 
                245                 250                 255     


His Leu Ala Asn Val Val Met Asn Trp Ala Gly Met Arg Cys Pro Tyr 
            260                 265                 270         


Lys Leu Leu Arg Met Val Leu Ala Leu Val Cys Met Ser Ser Glu Val 
        275                 280                 285             


Gly Arg Ala Val Trp Leu Arg Phe Ser Pro Pro Leu Pro Ala Ser Gly 
    290                 295                 300                 


Pro Gln Pro Ser Phe Met Ala His Leu Ala Gly Ala Val Val Gly Val 
305                 310                 315                 320 


Ser Met Gly Leu Thr Ile Leu Arg Ser Tyr Glu Glu Arg Leu Arg Asp 
                325                 330                 335     


Gln Cys Gly Trp Trp Val Val Leu Leu Ala Tyr Gly Thr Phe Leu Leu 
            340                 345                 350         


Phe Ala Val Phe Trp Asn Val Phe Ala Tyr Asp Leu Leu Gly Ala His 
        355                 360                 365             


Ile Pro Pro Pro Pro 
    370             


<210>  2932
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  2932

Met Cys Thr Gly Lys Cys Ala Arg Cys Val Gly Leu Ser Leu Ile Thr 
1               5                   10                  15      


Leu Cys Leu Val Cys Ile Val Ala Asn Ala Leu Leu Leu Val Pro Asn 
            20                  25                  30          


Gly Glu Thr Ser Trp Thr Asn Thr Asn His Leu Ser Leu Gln Val Trp 
        35                  40                  45              


Leu Met Gly Gly Phe Ile Gly Gly Gly Leu Met Val Leu Cys Pro Gly 
    50                  55                  60                  


Ile Ala Ala Val Arg Ala Gly Gly Lys Gly Cys Cys Gly Ala Gly Cys 
65                  70                  75                  80  


Cys Gly Asn Arg Cys Arg Met Leu Arg Ser Val Phe Ser Ser Ala Phe 
                85                  90                  95      


Gly Val Leu Gly Ala Ile Tyr Cys Leu Ser Val Ser Gly Ala Gly Leu 
            100                 105                 110         


Arg Asn Gly Pro Arg Cys Leu Met Asn Gly Glu Trp Gly Tyr His Phe 
        115                 120                 125             


Glu Asp Thr Ala Gly Ala Tyr Leu Leu Asn Arg Thr Leu Trp Asp Arg 
    130                 135                 140                 


Cys Glu Ala Pro Pro Arg Val Val Pro Trp Asn Val Thr Leu Phe Ser 
145                 150                 155                 160 


Leu Leu Val Ala Ala Ser Cys Leu Glu Ile Val Leu Cys Gly Ile Gln 
                165                 170                 175     


Leu Val Asn Ala Thr Ile Gly Val Phe Cys Gly Asp Cys Arg Lys Lys 
            180                 185                 190         


Gln Asp Thr Pro His 
        195         


<210>  2933
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  2933

Met Ala Asn Tyr Thr Leu Ala Pro Glu Asp Glu Tyr Asp Val Leu Ile 
1               5                   10                  15      


Glu Gly Glu Leu Glu Ser Asp Glu Ala Glu Gln Cys Asp Lys Tyr Asp 
            20                  25                  30          


Ala Gln Ala Leu Ser Ala Gln Leu Val Pro Ser Leu Cys Ser Ala Val 
        35                  40                  45              


Phe Val Ile Gly Val Leu Asp Asn Leu Leu Val Val Leu Ile Leu Val 
    50                  55                  60                  


Lys Tyr Lys Gly Leu Lys Arg Val Glu Asn Ile Tyr Leu Leu Asn Leu 
65                  70                  75                  80  


Ala Val Ser Asn Leu Cys Phe Leu Leu Thr Leu Pro Phe Trp Ala His 
                85                  90                  95      


Ala Gly Gly Asp Pro Met Cys Lys Ile Leu Ile Gly Leu Tyr Phe Val 
            100                 105                 110         


Gly Leu Tyr Ser Glu Thr Phe Phe Asn Cys Leu Leu Thr Val Gln Arg 
        115                 120                 125             


Tyr Leu Val Phe Leu His Lys Gly Asn Phe Phe Ser Ala Arg Arg Arg 
    130                 135                 140                 


Val Pro Cys Gly Ile Ile Thr Ser Val Leu Ala Trp Val Thr Ala Ile 
145                 150                 155                 160 


Leu Ala Thr Leu Pro Glu Phe Val Val Tyr Lys Pro Gln Met Glu Asp 
                165                 170                 175     


Gln Lys Tyr Lys Cys Ala Phe Ser Arg Thr Pro Phe Leu Pro Ala Asp 
            180                 185                 190         


Glu Thr Phe Trp Lys His Phe Leu Thr Leu Lys Met Asn Ile Ser Val 
        195                 200                 205             


Leu Val Leu Pro Leu Phe Ile Phe Thr Phe Leu Tyr Val Gln Met Arg 
    210                 215                 220                 


Lys Thr Leu Arg Phe Arg Glu Gln Arg Tyr Ser Leu Phe Lys Leu Val 
225                 230                 235                 240 


Phe Ala Ile Met Val Val Phe Leu Leu Met Trp Ala Pro Tyr Asn Ile 
                245                 250                 255     


Ala Phe Phe Leu Ser Thr Phe Lys Glu His Phe Ser Leu Ser Asp Cys 
            260                 265                 270         


Lys Ser Ser Tyr Asn Leu Asp Lys Ser Val His Ile Thr Lys Leu Ile 
        275                 280                 285             


Ala Thr Thr His Cys Cys Ile Asn Pro Leu Leu Tyr Ala Phe Leu Asp 
    290                 295                 300                 


Gly Thr Phe Ser Lys Tyr Leu Cys Arg Cys Phe His Leu Arg Ser Asn 
305                 310                 315                 320 


Thr Pro Leu Gln Pro Arg Gly Gln Ser Ala Gln Gly Thr Ser Arg Glu 
                325                 330                 335     


Glu Pro Asp His Ser Thr Glu Val 
            340                 


<210>  2934
<211>  1074
<212>  PRT
<213>  Homo sapiens

<400>  2934

Met Lys Gly Thr Cys Val Ile Ala Trp Leu Phe Ser Ser Leu Gly Leu 
1               5                   10                  15      


Trp Arg Leu Ala His Pro Glu Ala Gln Gly Thr Thr Gln Cys Gln Arg 
            20                  25                  30          


Thr Glu His Pro Val Ile Ser Tyr Lys Glu Ile Gly Pro Trp Leu Arg 
        35                  40                  45              


Glu Phe Arg Ala Lys Asn Ala Val Asp Phe Ser Gln Leu Thr Phe Asp 
    50                  55                  60                  


Pro Gly Gln Lys Glu Leu Val Val Gly Ala Arg Asn Tyr Leu Phe Arg 
65                  70                  75                  80  


Leu Gln Leu Glu Asp Leu Ser Leu Ile Gln Ala Val Glu Trp Glu Cys 
                85                  90                  95      


Asp Glu Ala Thr Lys Lys Ala Cys Tyr Ser Lys Gly Lys Ser Lys Glu 
            100                 105                 110         


Glu Cys Gln Asn Tyr Ile Arg Val Leu Leu Val Gly Gly Asp Arg Leu 
        115                 120                 125             


Phe Thr Cys Gly Thr Asn Ala Phe Thr Pro Val Cys Thr Asn Arg Ser 
    130                 135                 140                 


Leu Ser Asn Leu Thr Glu Ile His Asp Gln Ile Ser Gly Met Ala Arg 
145                 150                 155                 160 


Cys Pro Tyr Ser Pro Gln His Asn Ser Thr Ala Leu Leu Thr Ala Gly 
                165                 170                 175     


Gly Glu Leu Tyr Ala Ala Thr Ala Met Asp Phe Pro Gly Arg Asp Pro 
            180                 185                 190         


Ala Ile Tyr Arg Ser Leu Gly Ile Leu Pro Pro Leu Arg Thr Ala Gln 
        195                 200                 205             


Tyr Asn Ser Lys Trp Leu Asn Glu Pro Asn Phe Val Ser Ser Tyr Asp 
    210                 215                 220                 


Ile Gly Asn Phe Thr Tyr Phe Phe Phe Arg Glu Asn Ala Val Glu His 
225                 230                 235                 240 


Asp Cys Gly Lys Thr Val Phe Ser Arg Ala Ala Arg Val Cys Lys Asn 
                245                 250                 255     


Asp Ile Gly Gly Arg Phe Leu Leu Glu Asp Thr Trp Thr Thr Phe Met 
            260                 265                 270         


Lys Ala Arg Leu Asn Cys Ser Arg Pro Gly Glu Val Pro Phe Tyr Tyr 
        275                 280                 285             


Asn Glu Leu Gln Ser Thr Phe Phe Leu Pro Glu Leu Asp Leu Ile Tyr 
    290                 295                 300                 


Gly Ile Phe Thr Thr Asn Val Asn Ser Ile Ala Ala Ser Ala Val Cys 
305                 310                 315                 320 


Val Phe Asn Leu Ser Ala Ile Ala Gln Ala Phe Ser Gly Pro Phe Lys 
                325                 330                 335     


Tyr Gln Glu Asn Ser Arg Ser Ala Trp Leu Pro Tyr Pro Asn Pro Asn 
            340                 345                 350         


Pro His Phe Gln Cys Gly Thr Val Asp Gln Gly Leu Tyr Val Asn Leu 
        355                 360                 365             


Thr Glu Arg Asn Leu Gln Asp Ala Gln Lys Phe Ile Leu Met His Glu 
    370                 375                 380                 


Val Val Gln Pro Val Thr Thr Val Pro Ser Phe Met Glu Asp Asn Ser 
385                 390                 395                 400 


Arg Phe Ser His Val Ala Val Asp Val Val Gln Gly Arg Glu Ala Leu 
                405                 410                 415     


Val His Ile Ile Tyr Leu Ala Thr Asp Tyr Gly Thr Ile Lys Lys Val 
            420                 425                 430         


Arg Val Pro Leu Asn Gln Thr Ser Ser Ser Cys Leu Leu Glu Glu Ile 
        435                 440                 445             


Glu Leu Phe Pro Glu Arg Arg Arg Glu Pro Ile Arg Ser Leu Gln Ile 
    450                 455                 460                 


Leu His Ser Gln Ser Val Leu Phe Val Gly Leu Arg Glu His Val Val 
465                 470                 475                 480 


Lys Ile Pro Leu Lys Arg Cys Gln Phe Tyr Arg Thr Arg Ser Thr Cys 
                485                 490                 495     


Ile Gly Ala Gln Asp Pro Tyr Cys Gly Trp Asp Val Val Met Lys Lys 
            500                 505                 510         


Cys Thr Ser Leu Glu Glu Ser Leu Ser Met Thr Gln Trp Glu Gln Ser 
        515                 520                 525             


Ile Ser Ala Cys Pro Thr Arg Asn Leu Thr Val Asp Gly His Phe Gly 
    530                 535                 540                 


Val Trp Ser Pro Trp Thr Pro Cys Thr His Thr Asp Gly Ser Ala Val 
545                 550                 555                 560 


Gly Ser Cys Leu Cys Arg Thr Arg Ser Cys Asp Ser Pro Ala Pro Gln 
                565                 570                 575     


Cys Gly Gly Trp Gln Cys Glu Gly Pro Gly Met Glu Ile Ala Asn Cys 
            580                 585                 590         


Ser Arg Asn Gly Gly Trp Thr Pro Trp Thr Ser Trp Ser Pro Cys Ser 
        595                 600                 605             


Thr Thr Cys Gly Ile Gly Phe Gln Val Arg Gln Arg Ser Cys Ser Asn 
    610                 615                 620                 


Pro Thr Pro Arg His Gly Gly Arg Val Cys Val Gly Gln Asn Arg Glu 
625                 630                 635                 640 


Glu Arg Tyr Cys Asn Glu His Leu Leu Cys Pro Pro His Met Phe Trp 
                645                 650                 655     


Thr Gly Trp Gly Pro Trp Glu Arg Cys Thr Ala Gln Cys Gly Gly Gly 
            660                 665                 670         


Ile Gln Ala Arg Arg Arg Ile Cys Glu Asn Gly Pro Asp Cys Ala Gly 
        675                 680                 685             


Cys Asn Val Glu Tyr Gln Ser Cys Asn Thr Asn Pro Cys Pro Glu Leu 
    690                 695                 700                 


Lys Lys Thr Thr Pro Trp Thr Pro Trp Thr Pro Val Asn Ile Ser Asp 
705                 710                 715                 720 


Asn Gly Gly His Tyr Glu Gln Arg Phe Arg Tyr Thr Cys Lys Ala Arg 
                725                 730                 735     


Leu Ala Asp Pro Asn Leu Leu Glu Val Gly Arg Gln Arg Ile Glu Met 
            740                 745                 750         


Arg Tyr Cys Ser Ser Asp Gly Thr Ser Gly Cys Ser Thr Asp Gly Leu 
        755                 760                 765             


Ser Gly Asp Phe Leu Arg Ala Gly Arg Tyr Ser Ala His Thr Val Asn 
    770                 775                 780                 


Gly Ala Trp Ser Ala Trp Thr Ser Trp Ser Gln Cys Ser Arg Asp Cys 
785                 790                 795                 800 


Ser Arg Gly Ile Arg Asn Arg Lys Arg Val Cys Asn Asn Pro Glu Pro 
                805                 810                 815     


Lys Tyr Gly Gly Met Pro Cys Leu Gly Pro Ser Leu Glu Tyr Gln Glu 
            820                 825                 830         


Cys Asn Ile Leu Pro Cys Pro Val Asp Gly Val Trp Ser Cys Trp Ser 
        835                 840                 845             


Pro Trp Thr Lys Cys Ser Ala Thr Cys Gly Gly Gly His Tyr Met Arg 
    850                 855                 860                 


Thr Arg Ser Cys Ser Asn Pro Ala Pro Ala Tyr Gly Gly Asp Ile Cys 
865                 870                 875                 880 


Leu Gly Leu His Thr Glu Glu Ala Leu Cys Asn Thr Gln Pro Cys Pro 
                885                 890                 895     


Glu Ser Trp Ser Glu Trp Ser Asp Trp Ser Glu Cys Glu Ala Ser Gly 
            900                 905                 910         


Val Gln Val Arg Ala Arg Gln Cys Ile Leu Leu Phe Pro Met Gly Ser 
        915                 920                 925             


Gln Cys Ser Gly Asn Thr Thr Glu Ser Arg Pro Cys Val Phe Asp Ser 
    930                 935                 940                 


Asn Phe Ile Pro Glu Val Ser Val Ala Arg Ser Ser Ser Val Glu Glu 
945                 950                 955                 960 


Lys Arg Cys Gly Glu Phe Asn Met Phe His Met Ile Ala Val Gly Leu 
                965                 970                 975     


Ser Ser Ser Ile Leu Gly Cys Leu Leu Thr Leu Leu Val Tyr Thr Tyr 
            980                 985                 990         


Cys Gln Arg Tyr Gln Gln Gln Ser  His Asp Ala Thr Val  Ile His Pro 
        995                 1000                 1005             


Val Ser  Pro Ala Pro Leu Asn  Thr Ser Ile Thr Asn  His Ile Asn 
    1010                 1015                 1020             


Lys Leu  Asp Lys Tyr Asp Ser  Val Glu Ala Ile Lys  Ala Phe Asn 
    1025                 1030                 1035             


Lys Asn  Asn Leu Ile Leu Glu  Glu Arg Asn Lys Tyr  Phe Asn Pro 
    1040                 1045                 1050             


His Leu  Thr Gly Lys Thr Tyr  Ser Asn Ala Tyr Phe  Thr Asp Leu 
    1055                 1060                 1065             


Asn Asn  Tyr Asp Glu Tyr 
    1070                 


<210>  2935
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  2935

Met Arg Ala Val Phe Ile Gln Gly Ala Glu Glu His Pro Ala Ala Phe 
1               5                   10                  15      


Cys Tyr Gln Val Asn Gly Ser Cys Pro Arg Thr Val His Thr Leu Gly 
            20                  25                  30          


Ile Gln Leu Val Ile Tyr Leu Ala Cys Ala Ala Gly Met Leu Ile Ile 
        35                  40                  45              


Val Leu Gly Asn Val Phe Val Ala Phe Ala Val Ser Tyr Phe Lys Ala 
    50                  55                  60                  


Leu His Thr Pro Thr Asn Phe Leu Leu Leu Ser Leu Ala Leu Ala Asp 
65                  70                  75                  80  


Met Phe Leu Gly Leu Leu Val Leu Pro Leu Ser Thr Ile Arg Ser Val 
                85                  90                  95      


Glu Ser Cys Trp Phe Phe Gly Asp Phe Leu Cys Arg Leu His Thr Tyr 
            100                 105                 110         


Leu Asp Thr Leu Phe Cys Leu Thr Ser Ile Phe His Leu Cys Phe Ile 
        115                 120                 125             


Ser Ile Asp Arg His Cys Ala Ile Cys Asp Pro Leu Leu Tyr Pro Ser 
    130                 135                 140                 


Lys Phe Thr Val Arg Val Ala Leu Arg Tyr Ile Leu Ala Gly Trp Gly 
145                 150                 155                 160 


Val Pro Ala Ala Tyr Thr Ser Leu Phe Leu Tyr Thr Asp Val Val Glu 
                165                 170                 175     


Thr Arg Leu Ser Gln Trp Leu Glu Glu Met Pro Cys Val Gly Ser Cys 
            180                 185                 190         


Gln Leu Leu Leu Asn Lys Phe Trp Gly Trp Leu Asn Phe Pro Leu Phe 
        195                 200                 205             


Phe Val Pro Cys Leu Ile Met Ile Ser Leu Tyr Val Lys Ile Phe Val 
    210                 215                 220                 


Val Ala Thr Arg Gln Ala Gln Gln Ile Thr Thr Leu Ser Lys Ser Leu 
225                 230                 235                 240 


Ala Gly Ala Ala Lys His Glu Arg Lys Ala Ala Lys Thr Leu Gly Ile 
                245                 250                 255     


Ala Val Gly Ile Tyr Leu Leu Cys Trp Leu Pro Phe Thr Ile Asp Thr 
            260                 265                 270         


Met Val Asp Ser Leu Leu His Phe Ile Thr Pro Pro Leu Val Phe Asp 
        275                 280                 285             


Ile Phe Ile Trp Phe Ala Tyr Phe Asn Ser Ala Cys Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Val Phe Ser Tyr Gln Trp Phe Arg Lys Ala Leu Lys Leu Thr Leu 
305                 310                 315                 320 


Ser Gln Lys Val Phe Ser Pro Gln Thr Arg Thr Val Asp Leu Tyr Gln 
                325                 330                 335     


Glu 
    


<210>  2936
<211>  1307
<212>  PRT
<213>  Homo sapiens

<400>  2936

Met Glu Leu Glu Asp Gly Val Val Tyr Gln Glu Glu Pro Gly Gly Ser 
1               5                   10                  15      


Gly Ala Val Met Ser Glu Arg Val Ser Gly Leu Ala Gly Ser Ile Tyr 
            20                  25                  30          


Arg Glu Phe Glu Arg Leu Ile Gly Arg Tyr Asp Glu Glu Val Val Lys 
        35                  40                  45              


Glu Leu Met Pro Leu Val Val Ala Val Leu Glu Asn Leu Asp Ser Val 
    50                  55                  60                  


Phe Ala Gln Asp Gln Glu His Gln Val Glu Leu Glu Leu Leu Arg Asp 
65                  70                  75                  80  


Asp Asn Glu Gln Leu Ile Thr Gln Tyr Glu Arg Glu Lys Ala Leu Arg 
                85                  90                  95      


Lys His Ala Glu Glu Lys Phe Ile Glu Phe Glu Asp Ser Gln Glu Gln 
            100                 105                 110         


Glu Lys Lys Asp Leu Gln Thr Arg Val Glu Ser Leu Glu Ser Gln Thr 
        115                 120                 125             


Arg Gln Leu Glu Leu Lys Ala Lys Asn Tyr Ala Asp Gln Ile Ser Arg 
    130                 135                 140                 


Leu Glu Glu Arg Glu Ala Glu Leu Lys Lys Glu Tyr Asn Ala Leu His 
145                 150                 155                 160 


Gln Arg His Thr Glu Met Ile His Asn Tyr Met Glu His Leu Glu Arg 
                165                 170                 175     


Thr Lys Leu His Gln Leu Ser Gly Ser Asp Gln Leu Glu Ser Thr Ala 
            180                 185                 190         


His Ser Arg Ile Arg Lys Glu Arg Pro Ile Ser Leu Gly Ile Phe Pro 
        195                 200                 205             


Leu Pro Ala Gly Asp Gly Leu Leu Thr Pro Asp Ala Gln Lys Gly Gly 
    210                 215                 220                 


Glu Thr Pro Gly Ser Glu Gln Trp Lys Phe Gln Glu Leu Ser Gln Pro 
225                 230                 235                 240 


Arg Ser His Thr Ser Leu Lys Asp Glu Leu Ser Asp Val Ser Gln Gly 
                245                 250                 255     


Gly Ser Lys Ala Thr Thr Pro Ala Ser Thr Ala Asn Ser Asp Val Ala 
            260                 265                 270         


Thr Ile Pro Thr Asp Thr Pro Leu Lys Glu Glu Asn Glu Gly Phe Val 
        275                 280                 285             


Lys Val Thr Asp Ala Pro Asn Lys Ser Glu Ile Ser Lys His Ile Glu 
    290                 295                 300                 


Val Gln Val Ala Gln Glu Thr Arg Asn Val Ser Thr Gly Ser Ala Glu 
305                 310                 315                 320 


Asn Glu Glu Lys Ser Glu Val Gln Ala Ile Ile Glu Ser Thr Pro Glu 
                325                 330                 335     


Leu Asp Met Asp Lys Asp Leu Ser Gly Tyr Lys Gly Ser Ser Thr Pro 
            340                 345                 350         


Thr Lys Gly Ile Glu Asn Lys Ala Phe Asp Arg Asn Thr Glu Ser Leu 
        355                 360                 365             


Phe Glu Glu Leu Ser Ser Ala Gly Ser Gly Leu Ile Gly Asp Val Asp 
    370                 375                 380                 


Glu Gly Ala Asp Leu Leu Gly Met Gly Arg Glu Val Glu Asn Leu Ile 
385                 390                 395                 400 


Leu Glu Asn Thr Gln Leu Leu Glu Thr Lys Asn Ala Leu Asn Ile Val 
                405                 410                 415     


Lys Asn Asp Leu Ile Ala Lys Val Asp Glu Leu Thr Cys Glu Lys Asp 
            420                 425                 430         


Val Leu Gln Gly Glu Leu Glu Ala Val Lys Gln Ala Lys Leu Lys Leu 
        435                 440                 445             


Glu Glu Lys Asn Arg Glu Leu Glu Glu Glu Leu Arg Lys Ala Arg Ala 
    450                 455                 460                 


Glu Ala Glu Asp Ala Arg Gln Lys Ala Lys Asp Asp Asp Asp Ser Asp 
465                 470                 475                 480 


Ile Pro Thr Ala Gln Arg Lys Arg Phe Thr Arg Val Glu Met Ala Arg 
                485                 490                 495     


Val Leu Met Glu Arg Asn Gln Tyr Lys Glu Arg Leu Met Glu Leu Gln 
            500                 505                 510         


Glu Ala Val Arg Trp Thr Glu Met Ile Arg Ala Ser Arg Glu Asn Pro 
        515                 520                 525             


Ala Met Gln Glu Lys Lys Arg Ser Ser Ile Trp Gln Phe Phe Ser Arg 
    530                 535                 540                 


Leu Phe Ser Ser Ser Ser Asn Thr Thr Lys Lys Pro Glu Pro Pro Val 
545                 550                 555                 560 


Asn Leu Lys Tyr Asn Ala Pro Thr Ser His Val Thr Pro Ser Val Lys 
                565                 570                 575     


Lys Arg Ser Ser Thr Leu Ser Gln Leu Pro Gly Asp Lys Ser Lys Ala 
            580                 585                 590         


Phe Asp Phe Leu Ser Glu Glu Thr Glu Ala Ser Leu Ala Ser Arg Arg 
        595                 600                 605             


Glu Gln Lys Arg Glu Gln Tyr Arg Gln Val Lys Ala His Val Gln Lys 
    610                 615                 620                 


Glu Asp Gly Arg Val Gln Ala Phe Gly Trp Ser Leu Pro Gln Lys Tyr 
625                 630                 635                 640 


Lys Gln Val Thr Asn Gly Gln Gly Glu Asn Lys Met Lys Asn Leu Pro 
                645                 650                 655     


Val Pro Val Tyr Leu Arg Pro Leu Asp Glu Lys Asp Thr Ser Met Lys 
            660                 665                 670         


Leu Trp Cys Ala Val Gly Val Asn Leu Ser Gly Gly Lys Thr Arg Asp 
        675                 680                 685             


Gly Gly Ser Val Val Gly Ala Ser Val Phe Tyr Lys Asp Val Ala Gly 
    690                 695                 700                 


Leu Asp Thr Glu Gly Ser Lys Gln Arg Ser Ala Ser Gln Ser Ser Leu 
705                 710                 715                 720 


Asp Lys Leu Asp Gln Glu Leu Lys Glu Gln Gln Lys Glu Leu Lys Asn 
                725                 730                 735     


Gln Glu Glu Leu Ser Ser Leu Val Trp Ile Cys Thr Ser Thr His Ser 
            740                 745                 750         


Ala Thr Lys Val Leu Ile Ile Asp Ala Val Gln Pro Gly Asn Ile Leu 
        755                 760                 765             


Asp Ser Phe Thr Val Cys Asn Ser His Val Leu Cys Ile Ala Ser Val 
    770                 775                 780                 


Pro Gly Ala Arg Glu Thr Asp Tyr Pro Ala Gly Glu Asp Leu Ser Glu 
785                 790                 795                 800 


Ser Gly Gln Val Asp Lys Ala Ser Leu Cys Gly Ser Met Thr Ser Asn 
                805                 810                 815     


Ser Ser Ala Glu Thr Asp Ser Leu Leu Gly Gly Ile Thr Val Val Gly 
            820                 825                 830         


Cys Ser Ala Glu Gly Val Thr Gly Ala Ala Thr Ser Pro Ser Thr Asn 
        835                 840                 845             


Gly Ala Ser Pro Val Met Asp Lys Pro Pro Glu Met Glu Ala Glu Asn 
    850                 855                 860                 


Ser Glu Val Asp Glu Asn Val Pro Thr Ala Glu Glu Ala Thr Glu Ala 
865                 870                 875                 880 


Thr Glu Gly Asn Ala Gly Ser Ala Glu Asp Thr Val Asp Ile Ser Gln 
                885                 890                 895     


Thr Gly Val Tyr Thr Glu His Val Phe Thr Asp Pro Leu Gly Val Gln 
            900                 905                 910         


Ile Pro Glu Asp Leu Ser Pro Val Tyr Gln Ser Ser Asn Asp Ser Asp 
        915                 920                 925             


Ala Tyr Lys Asp Gln Ile Ser Val Leu Pro Asn Glu Gln Asp Leu Val 
    930                 935                 940                 


Arg Glu Glu Ala Gln Lys Met Ser Ser Leu Leu Pro Thr Met Trp Leu 
945                 950                 955                 960 


Gly Ala Gln Asn Gly Cys Leu Tyr Val His Ser Ser Val Ala Gln Trp 
                965                 970                 975     


Arg Lys Cys Leu His Ser Ile Lys Leu Lys Asp Ser Ile Leu Ser Ile 
            980                 985                 990         


Val His Val Lys Gly Ile Val Leu  Val Ala Leu Ala Asp  Gly Thr Leu 
        995                 1000                 1005             


Ala Ile  Phe His Arg Gly Val  Asp Gly Gln Trp Asp  Leu Ser Asn 
    1010                 1015                 1020             


Tyr His  Leu Leu Asp Leu Gly  Arg Pro His His Ser  Ile Arg Cys 
    1025                 1030                 1035             


Met Thr  Val Val His Asp Lys  Val Trp Cys Gly Tyr  Arg Asn Lys 
    1040                 1045                 1050             


Ile Tyr  Val Val Gln Pro Lys  Ala Met Lys Ile Glu  Lys Ser Phe 
    1055                 1060                 1065             


Asp Ala  His Pro Arg Lys Glu  Ser Gln Val Arg Gln  Leu Ala Trp 
    1070                 1075                 1080             


Val Gly  Asp Gly Val Trp Val  Ser Ile Arg Leu Asp  Ser Thr Leu 
    1085                 1090                 1095             


Arg Leu  Tyr His Ala His Thr  Tyr Gln His Leu Gln  Asp Val Asp 
    1100                 1105                 1110             


Ile Glu  Pro Tyr Val Ser Lys  Met Leu Gly Thr Gly  Lys Leu Gly 
    1115                 1120                 1125             


Phe Ser  Phe Val Arg Ile Thr  Ala Leu Met Val Ser  Cys Asn Arg 
    1130                 1135                 1140             


Leu Trp  Val Gly Thr Gly Asn  Gly Val Ile Ile Ser  Ile Pro Leu 
    1145                 1150                 1155             


Thr Glu  Thr Asn Lys Thr Ser  Gly Val Pro Gly Asn  Arg Pro Gly 
    1160                 1165                 1170             


Ser Val  Ile Arg Val Tyr Gly  Asp Glu Asn Ser Asp  Lys Val Thr 
    1175                 1180                 1185             


Pro Gly  Thr Phe Ile Pro Tyr  Cys Ser Met Ala His  Ala Gln Leu 
    1190                 1195                 1200             


Cys Phe  His Gly His Arg Asp  Ala Val Lys Phe Phe  Val Ala Val 
    1205                 1210                 1215             


Pro Gly  Gln Val Ile Ser Pro  Gln Ser Ser Ser Ser  Gly Thr Asp 
    1220                 1225                 1230             


Leu Thr  Gly Asp Lys Ala Gly  Pro Ser Ala Gln Glu  Pro Gly Ser 
    1235                 1240                 1245             


Gln Thr  Pro Leu Lys Ser Met  Leu Val Ile Ser Gly  Gly Glu Gly 
    1250                 1255                 1260             


Tyr Ile  Asp Phe Arg Met Gly  Asp Glu Gly Gly Glu  Ser Glu Leu 
    1265                 1270                 1275             


Leu Gly  Glu Asp Leu Pro Leu  Glu Pro Ser Val Thr  Lys Ala Glu 
    1280                 1285                 1290             


Arg Ser  His Leu Ile Val Trp  Gln Val Met Tyr Gly  Asn Glu 
    1295                 1300                 1305         


<210>  2937
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  2937

Met Ala Thr Thr Val Pro Asp Gly Cys Arg Asn Gly Leu Lys Ser Lys 
1               5                   10                  15      


Tyr Tyr Arg Leu Cys Asp Lys Ala Glu Ala Trp Gly Ile Val Leu Glu 
            20                  25                  30          


Thr Val Ala Thr Ala Gly Val Val Thr Ser Val Ala Phe Met Leu Thr 
        35                  40                  45              


Leu Pro Ile Leu Val Cys Lys Val Gln Asp Ser Asn Arg Arg Lys Met 
    50                  55                  60                  


Leu Pro Thr Gln Phe Leu Phe Leu Leu Gly Val Leu Gly Ile Phe Gly 
65                  70                  75                  80  


Leu Thr Phe Ala Phe Ile Ile Gly Leu Asp Gly Ser Thr Gly Pro Thr 
                85                  90                  95      


Arg Phe Phe Leu Phe Gly Ile Leu Phe Ser Ile Cys Phe Ser Cys Leu 
            100                 105                 110         


Leu Ala His Ala Val Ser Leu Thr Lys Leu Val Arg Gly Arg Lys Pro 
        115                 120                 125             


Leu Ser Leu Leu Val Ile Leu Gly Leu Ala Val Gly Phe Ser Leu Val 
    130                 135                 140                 


Gln Asp Val Ile Ala Ile Glu Tyr Ile Val Leu Thr Met Asn Arg Thr 
145                 150                 155                 160 


Asn Val Asn Val Phe Ser Glu Leu Ser Ala Pro Arg Arg Asn Glu Asp 
                165                 170                 175     


Phe Val Leu Leu Leu Thr Tyr Val Leu Phe Leu Met Ala Leu Thr Phe 
            180                 185                 190         


Leu Met Ser Ser Phe Thr Phe Cys Gly Ser Phe Thr Gly Trp Lys Arg 
        195                 200                 205             


His Gly Ala His Ile Tyr Leu Thr Met Leu Leu Ser Ile Ala Ile Trp 
    210                 215                 220                 


Val Ala Trp Ile Thr Leu Leu Met Leu Pro Asp Phe Asp Arg Arg Trp 
225                 230                 235                 240 


Asp Asp Thr Ile Leu Ser Ser Ala Leu Ala Ala Asn Gly Trp Val Phe 
                245                 250                 255     


Leu Leu Ala Tyr Val Ser Pro Glu Phe Trp Leu Leu Thr Lys Gln Arg 
            260                 265                 270         


Asn Pro Met Asp Tyr Pro Val Glu Asp Ala Phe Cys Lys Pro Gln Leu 
        275                 280                 285             


Val Lys Lys Ser Tyr Gly Val Glu Asn Arg Ala Tyr Ser Gln Glu Glu 
    290                 295                 300                 


Ile Thr Gln Gly Phe Glu Glu Thr Gly Asp Thr Leu Tyr Ala Pro Tyr 
305                 310                 315                 320 


Ser Thr His Phe Gln Leu Gln Asn Gln Pro Pro Gln Lys Glu Phe Ser 
                325                 330                 335     


Ile Pro Arg Ala His Ala Trp Pro Ser Pro Tyr Lys Asp Tyr Glu Val 
            340                 345                 350         


Lys Lys Glu Gly Ser 
        355         


<210>  2938
<211>  511
<212>  PRT
<213>  Homo sapiens

<400>  2938

Met Val Asp Ser Thr Glu Tyr Glu Val Ala Ser Gln Pro Glu Val Glu 
1               5                   10                  15      


Thr Ser Pro Leu Gly Asp Gly Ala Ser Pro Gly Pro Glu Gln Val Lys 
            20                  25                  30          


Leu Lys Lys Glu Ile Ser Leu Leu Asn Gly Val Cys Leu Ile Val Gly 
        35                  40                  45              


Asn Met Ile Gly Ser Gly Ile Phe Val Ser Pro Lys Gly Val Leu Ile 
    50                  55                  60                  


Tyr Ser Ala Ser Phe Gly Leu Ser Leu Val Ile Trp Ala Val Gly Gly 
65                  70                  75                  80  


Leu Phe Ser Val Phe Gly Ala Leu Cys Tyr Ala Glu Leu Gly Thr Thr 
                85                  90                  95      


Ile Lys Lys Ser Gly Ala Ser Tyr Ala Tyr Ile Leu Glu Ala Phe Gly 
            100                 105                 110         


Gly Phe Leu Ala Phe Ile Arg Leu Trp Thr Ser Leu Leu Ile Ile Glu 
        115                 120                 125             


Pro Thr Ser Gln Ala Ile Ile Ala Ile Thr Phe Ala Asn Tyr Met Val 
    130                 135                 140                 


Gln Pro Leu Phe Pro Ser Cys Phe Ala Pro Tyr Ala Ala Ser Arg Leu 
145                 150                 155                 160 


Leu Ala Ala Ala Cys Ile Cys Leu Leu Thr Phe Ile Asn Cys Ala Tyr 
                165                 170                 175     


Val Lys Trp Gly Thr Leu Val Gln Asp Ile Phe Thr Tyr Ala Lys Val 
            180                 185                 190         


Leu Ala Leu Ile Ala Val Ile Val Ala Gly Ile Val Arg Leu Gly Gln 
        195                 200                 205             


Gly Ala Ser Thr His Phe Glu Asn Ser Phe Glu Gly Ser Ser Phe Ala 
    210                 215                 220                 


Val Gly Asp Ile Ala Leu Ala Leu Tyr Ser Ala Leu Phe Ser Tyr Ser 
225                 230                 235                 240 


Gly Trp Asp Thr Leu Asn Tyr Val Thr Glu Glu Ile Lys Asn Pro Glu 
                245                 250                 255     


Arg Asn Leu Pro Leu Ser Ile Gly Ile Ser Met Pro Ile Val Thr Ile 
            260                 265                 270         


Ile Tyr Ile Leu Thr Asn Val Ala Tyr Tyr Thr Val Leu Asp Met Arg 
        275                 280                 285             


Asp Ile Leu Ala Ser Asp Ala Val Ala Val Thr Phe Ala Asp Gln Ile 
    290                 295                 300                 


Phe Gly Ile Phe Asn Trp Ile Ile Pro Leu Ser Val Ala Leu Ser Cys 
305                 310                 315                 320 


Phe Gly Gly Leu Asn Ala Ser Ile Val Ala Ala Ser Arg Leu Phe Phe 
                325                 330                 335     


Val Gly Ser Arg Glu Gly His Leu Pro Asp Ala Ile Cys Met Ile His 
            340                 345                 350         


Val Glu Arg Phe Thr Pro Val Pro Ser Leu Leu Phe Asn Gly Ile Met 
        355                 360                 365             


Ala Leu Ile Tyr Leu Cys Val Glu Asp Ile Phe Gln Leu Ile Asn Tyr 
    370                 375                 380                 


Tyr Ser Phe Ser Tyr Trp Phe Phe Val Gly Leu Ser Ile Val Gly Gln 
385                 390                 395                 400 


Leu Tyr Leu Arg Trp Lys Glu Pro Asp Arg Pro Arg Pro Leu Lys Leu 
                405                 410                 415     


Ser Val Phe Phe Pro Ile Val Phe Cys Leu Cys Thr Ile Phe Leu Val 
            420                 425                 430         


Ala Val Pro Leu Tyr Ser Asp Thr Ile Asn Ser Leu Ile Gly Ile Ala 
        435                 440                 445             


Ile Ala Leu Ser Gly Leu Pro Phe Tyr Phe Leu Ile Ile Arg Val Pro 
    450                 455                 460                 


Glu His Lys Arg Pro Leu Tyr Leu Arg Arg Ile Val Gly Ser Ala Thr 
465                 470                 475                 480 


Arg Tyr Leu Gln Val Leu Cys Met Ser Val Ala Ala Glu Met Asp Leu 
                485                 490                 495     


Glu Asp Gly Gly Glu Met Pro Lys Gln Arg Asp Pro Lys Ser Asn 
            500                 505                 510     


<210>  2939
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  2939

Met Glu Ala Arg Glu Pro Gly Arg Pro Thr Pro Thr Tyr His Leu Val 
1               5                   10                  15      


Pro Asn Thr Ser Gln Ser Gln Val Glu Glu Asp Val Ser Ser Pro Pro 
            20                  25                  30          


Gln Arg Ser Ser Glu Thr Met Gln Leu Lys Lys Glu Ile Ser Leu Leu 
        35                  40                  45              


Asn Gly Val Ser Leu Val Val Gly Asn Met Ile Gly Ser Gly Ile Phe 
    50                  55                  60                  


Val Ser Pro Lys Gly Val Leu Val His Thr Ala Ser Tyr Gly Met Ser 
65                  70                  75                  80  


Leu Ile Val Trp Ala Ile Gly Gly Leu Phe Ser Val Val Gly Ala Leu 
                85                  90                  95      


Cys Tyr Ala Glu Leu Gly Thr Thr Ile Thr Lys Ser Gly Ala Ser Tyr 
            100                 105                 110         


Ala Tyr Ile Leu Glu Ala Phe Gly Gly Phe Ile Ala Phe Ile Arg Leu 
        115                 120                 125             


Trp Val Ser Leu Leu Val Val Glu Pro Thr Gly Gln Ala Ile Ile Ala 
    130                 135                 140                 


Ile Thr Phe Ala Asn Tyr Ile Ile Gln Pro Ser Phe Pro Ser Cys Asp 
145                 150                 155                 160 


Pro Pro Tyr Leu Ala Cys Arg Leu Leu Ala Ala Ala Cys Ile Cys Leu 
                165                 170                 175     


Leu Thr Phe Val Asn Cys Ala Tyr Val Lys Trp Gly Thr Arg Val Gln 
            180                 185                 190         


Asp Thr Phe Thr Tyr Ala Lys Val Val Ala Leu Ile Ala Ile Ile Val 
        195                 200                 205             


Met Gly Leu Val Lys Leu Cys Gln Gly His Ser Glu His Phe Gln Asp 
    210                 215                 220                 


Ala Phe Glu Gly Ser Ser Trp Asp Met Gly Asn Leu Ser Leu Ala Leu 
225                 230                 235                 240 


Tyr Ser Ala Leu Phe Ser Tyr Ser Gly Trp Asp Thr Leu Asn Phe Val 
                245                 250                 255     


Thr Glu Glu Ile Lys Asn Pro Glu Arg Asn Leu Pro Leu Ala Ile Gly 
            260                 265                 270         


Ile Ser Met Pro Ile Val Thr Leu Ile Tyr Ile Leu Thr Asn Val Ala 
        275                 280                 285             


Tyr Tyr Thr Val Leu Asn Ile Ser Asp Val Leu Ser Ser Asp Ala Val 
    290                 295                 300                 


Ala Val Thr Phe Ala Asp Gln Thr Phe Gly Met Phe Ser Trp Thr Ile 
305                 310                 315                 320 


Pro Ile Ala Val Ala Leu Ser Cys Phe Gly Gly Leu Asn Ala Ser Ile 
                325                 330                 335     


Phe Ala Ser Ser Arg Leu Phe Phe Val Gly Ser Arg Glu Gly His Leu 
            340                 345                 350         


Pro Asp Leu Leu Ser Met Ile His Ile Glu Arg Phe Thr Pro Ile Pro 
        355                 360                 365             


Ala Leu Leu Phe Asn Cys Thr Met Ala Leu Ile Tyr Leu Ile Val Glu 
    370                 375                 380                 


Asp Val Phe Gln Leu Ile Asn Tyr Phe Ser Phe Ser Tyr Trp Phe Phe 
385                 390                 395                 400 


Val Gly Leu Ser Val Val Gly Gln Leu Tyr Leu Arg Trp Lys Glu Pro 
                405                 410                 415     


Lys Arg Pro Arg Pro Leu Lys Leu Ser Val Phe Phe Pro Ile Val Phe 
            420                 425                 430         


Cys Ile Cys Ser Val Phe Leu Val Ile Val Pro Leu Phe Thr Asp Thr 
        435                 440                 445             


Ile Asn Ser Leu Ile Gly Ile Gly Ile Ala Leu Ser Gly Val Pro Phe 
    450                 455                 460                 


Tyr Phe Met Gly Val Tyr Leu Pro Glu Ser Arg Arg Pro Leu Phe Ile 
465                 470                 475                 480 


Arg Asn Val Leu Ala Ala Ile Thr Arg Gly Thr Gln Gln Leu Cys Phe 
                485                 490                 495     


Cys Val Leu Thr Glu Leu Asp Val Ala Glu Glu Lys Lys Asp Glu Arg 
            500                 505                 510         


Lys Thr Asp 
        515 


<210>  2940
<211>  592
<212>  PRT
<213>  Homo sapiens

<400>  2940

Met Ala Thr Cys Trp Gln Ala Leu Trp Ala Tyr Arg Ser Tyr Leu Ile 
1               5                   10                  15      


Val Phe Phe Val Pro Ile Leu Leu Leu Pro Leu Pro Ile Leu Val Pro 
            20                  25                  30          


Ser Lys Glu Ala Tyr Cys Ala Tyr Ala Ile Ile Leu Met Ala Leu Phe 
        35                  40                  45              


Trp Cys Thr Glu Ala Leu Pro Leu Ala Val Thr Ala Leu Phe Pro Leu 
    50                  55                  60                  


Ile Leu Phe Pro Met Met Gly Ile Val Asp Ala Ser Glu Val Ala Val 
65                  70                  75                  80  


Glu Tyr Leu Lys Asp Ser Asn Leu Leu Phe Phe Gly Gly Leu Leu Val 
                85                  90                  95      


Ala Ile Ala Val Glu His Trp Asn Leu His Lys Arg Ile Ala Leu Arg 
            100                 105                 110         


Val Leu Leu Ile Val Gly Val Arg Pro Ala Pro Leu Ile Leu Gly Phe 
        115                 120                 125             


Met Leu Val Thr Ala Phe Leu Ser Met Trp Ile Ser Asn Thr Ala Thr 
    130                 135                 140                 


Ser Ala Met Met Val Pro Ile Ala His Ala Val Leu Asp Gln Leu His 
145                 150                 155                 160 


Ser Ser Gln Ala Ser Ser Asn Val Glu Glu Gly Ser Asn Asn Pro Thr 
                165                 170                 175     


Phe Glu Leu Gln Glu Pro Ser Pro Gln Lys Glu Val Thr Lys Leu Asp 
            180                 185                 190         


Asn Gly Gln Ala Leu Pro Val Thr Ser Ala Ser Ser Glu Gly Arg Ala 
        195                 200                 205             


His Leu Ser Gln Lys His Leu His Leu Thr Gln Cys Met Ser Leu Cys 
    210                 215                 220                 


Val Cys Tyr Ser Ala Ser Ile Gly Gly Ile Ala Thr Leu Thr Gly Thr 
225                 230                 235                 240 


Ala Pro Asn Leu Val Leu Gln Gly Gln Ile Asn Ser Leu Phe Pro Gln 
                245                 250                 255     


Asn Gly Asn Val Val Asn Phe Ala Ser Trp Phe Ser Phe Ala Phe Pro 
            260                 265                 270         


Thr Met Val Ile Leu Leu Leu Leu Ala Trp Leu Trp Leu Gln Ile Leu 
        275                 280                 285             


Phe Leu Gly Phe Asn Phe Arg Lys Asn Phe Gly Ile Gly Glu Lys Met 
    290                 295                 300                 


Gln Glu Gln Gln Gln Ala Ala Tyr Cys Val Ile Gln Thr Glu His Arg 
305                 310                 315                 320 


Leu Leu Gly Pro Met Thr Phe Ala Glu Lys Ala Ile Ser Ile Leu Phe 
                325                 330                 335     


Val Ile Leu Val Leu Leu Trp Phe Thr Arg Glu Pro Gly Phe Phe Leu 
            340                 345                 350         


Gly Trp Gly Asn Leu Ala Phe Pro Asn Ala Lys Gly Glu Ser Met Val 
        355                 360                 365             


Ser Asp Gly Thr Val Ala Ile Phe Ile Gly Ile Ile Met Phe Ile Ile 
    370                 375                 380                 


Pro Ser Lys Phe Pro Gly Leu Thr Gln Asp Pro Glu Asn Pro Gly Lys 
385                 390                 395                 400 


Leu Lys Ala Pro Leu Gly Leu Leu Asp Trp Lys Thr Val Asn Gln Lys 
                405                 410                 415     


Met Pro Trp Asn Ile Val Leu Leu Leu Gly Gly Gly Tyr Ala Leu Ala 
            420                 425                 430         


Lys Gly Ser Glu Arg Ser Gly Leu Ser Glu Trp Leu Gly Asn Lys Leu 
        435                 440                 445             


Thr Pro Leu Gln Ser Val Pro Ala Pro Ala Ile Ala Ile Ile Leu Ser 
    450                 455                 460                 


Leu Leu Val Ala Thr Phe Thr Glu Cys Thr Ser Asn Val Ala Thr Thr 
465                 470                 475                 480 


Thr Ile Phe Leu Pro Ile Leu Ala Ser Met Ala Gln Ala Ile Cys Leu 
                485                 490                 495     


His Pro Leu Tyr Val Met Leu Pro Cys Thr Leu Ala Thr Ser Leu Ala 
            500                 505                 510         


Phe Met Leu Pro Val Ala Thr Pro Pro Asn Ala Ile Val Phe Ser Phe 
        515                 520                 525             


Gly Asp Leu Lys Val Leu Asp Met Ala Arg Ala Gly Phe Leu Leu Asn 
    530                 535                 540                 


Ile Ile Gly Val Leu Ile Ile Ala Leu Ala Ile Asn Ser Trp Gly Ile 
545                 550                 555                 560 


Pro Leu Phe Ser Leu His Ser Phe Pro Ser Trp Ala Gln Ser Asn Thr 
                565                 570                 575     


Thr Ala Gln Cys Leu Pro Ser Leu Ala Asn Thr Thr Thr Pro Ser Pro 
            580                 585                 590         


<210>  2941
<211>  436
<212>  PRT
<213>  Homo sapiens

<400>  2941

Met Gln Pro Pro Pro Ser Leu Cys Gly Arg Ala Leu Val Ala Leu Val 
1               5                   10                  15      


Leu Ala Cys Gly Leu Ser Arg Ile Trp Gly Glu Glu Arg Gly Phe Pro 
            20                  25                  30          


Pro Asp Arg Ala Thr Pro Leu Leu Gln Thr Ala Glu Ile Met Thr Pro 
        35                  40                  45              


Pro Thr Lys Thr Leu Trp Pro Lys Gly Ser Asn Ala Ser Leu Ala Arg 
    50                  55                  60                  


Ser Leu Ala Pro Ala Glu Val Pro Lys Gly Asp Arg Thr Ala Gly Ser 
65                  70                  75                  80  


Pro Pro Arg Thr Ile Ser Pro Pro Pro Cys Gln Gly Pro Ile Glu Ile 
                85                  90                  95      


Lys Glu Thr Phe Lys Tyr Ile Asn Thr Val Val Ser Cys Leu Val Phe 
            100                 105                 110         


Val Leu Gly Ile Ile Gly Asn Ser Thr Leu Leu Arg Ile Ile Tyr Lys 
        115                 120                 125             


Asn Lys Cys Met Arg Asn Gly Pro Asn Ile Leu Ile Ala Ser Leu Ala 
    130                 135                 140                 


Leu Gly Asp Leu Leu His Ile Val Ile Asp Ile Pro Ile Asn Val Tyr 
145                 150                 155                 160 


Lys Leu Leu Ala Glu Asp Trp Pro Phe Gly Ala Glu Met Cys Lys Leu 
                165                 170                 175     


Val Pro Phe Ile Gln Lys Ala Ser Val Gly Ile Thr Val Leu Ser Leu 
            180                 185                 190         


Cys Ala Leu Ser Ile Asp Arg Tyr Arg Ala Val Ala Ser Trp Ser Arg 
        195                 200                 205             


Ile Lys Gly Ile Gly Val Pro Lys Trp Thr Ala Val Glu Ile Val Leu 
    210                 215                 220                 


Ile Trp Val Val Ser Val Val Leu Ala Val Pro Glu Ala Ile Gly Phe 
225                 230                 235                 240 


Asp Ile Ile Thr Met Asp Tyr Lys Gly Ser Tyr Leu Arg Ile Cys Leu 
                245                 250                 255     


Leu His Pro Val Gln Lys Thr Ala Phe Met Gln Phe Tyr Lys Thr Ala 
            260                 265                 270         


Lys Asp Trp Trp Leu Phe Ser Phe Tyr Phe Cys Leu Pro Leu Ala Ile 
        275                 280                 285             


Thr Ala Phe Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Arg Lys Lys 
    290                 295                 300                 


Ser Gly Met Gln Ile Ala Leu Asn Asp His Leu Lys Gln Arg Arg Glu 
305                 310                 315                 320 


Val Ala Lys Thr Val Phe Cys Leu Val Leu Val Phe Ala Leu Cys Trp 
                325                 330                 335     


Leu Pro Leu His Leu Ser Arg Ile Leu Lys Leu Thr Leu Tyr Asn Gln 
            340                 345                 350         


Asn Asp Pro Asn Arg Cys Glu Leu Leu Ser Phe Leu Leu Val Leu Asp 
        355                 360                 365             


Tyr Ile Gly Ile Asn Met Ala Ser Leu Asn Ser Cys Ile Asn Pro Ile 
    370                 375                 380                 


Ala Leu Tyr Leu Val Ser Lys Arg Phe Lys Asn Cys Phe Lys Ala Gly 
385                 390                 395                 400 


Pro His Val Gly Asn Lys Leu Val Met Leu Phe Ser Val Asn Ile Glu 
                405                 410                 415     


Cys Asp Gly Thr Val Asn Gln Asn Pro Thr Met Trp Pro Glu Arg Lys 
            420                 425                 430         


Ser Asn Asn Asn 
        435     


<210>  2942
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  2942

Met Lys Lys Thr Gln Thr Trp Ile Leu Thr Cys Ile Tyr Leu Gln Leu 
1               5                   10                  15      


Leu Leu Phe Asn Pro Leu Val Lys Thr Glu Gly Ile Cys Arg Asn Arg 
            20                  25                  30          


Val Thr Asn Asn Val Lys Asp Val Thr Lys Leu Val Ala Asn Leu Pro 
        35                  40                  45              


Lys Asp Tyr Met Ile Thr Leu Lys Tyr Val Pro Gly Met Asp Val Leu 
    50                  55                  60                  


Pro Ser His Cys Trp Ile Ser Glu Met Val Val Gln Leu Ser Asp Ser 
65                  70                  75                  80  


Leu Thr Asp Leu Leu Asp Lys Phe Ser Asn Ile Ser Glu Gly Leu Ser 
                85                  90                  95      


Asn Tyr Ser Ile Ile Asp Lys Leu Val Asn Ile Val Asp Asp Leu Val 
            100                 105                 110         


Glu Cys Val Lys Glu Asn Ser Ser Lys Asp Leu Lys Lys Ser Phe Lys 
        115                 120                 125             


Ser Pro Glu Pro Arg Leu Phe Thr Pro Glu Glu Phe Phe Arg Ile Phe 
    130                 135                 140                 


Asn Arg Ser Ile Asp Ala Phe Lys Asp Phe Val Val Ala Ser Glu Thr 
145                 150                 155                 160 


Ser Asp Cys Val Val Ser Ser Thr Leu Ser Pro Glu Lys Gly Lys Ala 
                165                 170                 175     


Lys Asn Pro Pro Gly Asp Ser Ser Leu His Trp Ala Ala Met Ala Leu 
            180                 185                 190         


Pro Ala Leu Phe Ser Leu Ile Ile Gly Phe Ala Phe Gly Ala Leu Tyr 
        195                 200                 205             


Trp Lys Lys Arg Gln Pro Ser Leu Thr Arg Ala Val Glu Asn Ile Gln 
    210                 215                 220                 


Ile Asn Glu Glu Asp Asn Glu Ile Ser Met Leu Gln Glu Lys Glu Arg 
225                 230                 235                 240 


Glu Phe Gln Glu Val 
                245 


<210>  2943
<211>  979
<212>  PRT
<213>  Homo sapiens

<400>  2943

Met Ala Leu Phe Ala Val Phe Gln Thr Thr Phe Phe Leu Thr Leu Leu 
1               5                   10                  15      


Ser Leu Arg Thr Tyr Gln Ser Glu Val Leu Ala Glu Arg Leu Pro Leu 
            20                  25                  30          


Thr Pro Val Ser Leu Lys Val Ser Thr Asn Ser Thr Arg Gln Ser Leu 
        35                  40                  45              


His Leu Gln Trp Thr Val His Asn Leu Pro Tyr His Gln Glu Leu Lys 
    50                  55                  60                  


Met Val Phe Gln Ile Gln Ile Ser Arg Ile Glu Thr Ser Asn Val Ile 
65                  70                  75                  80  


Trp Val Gly Asn Tyr Ser Thr Thr Val Lys Trp Asn Gln Val Leu His 
                85                  90                  95      


Trp Ser Trp Glu Ser Glu Leu Pro Leu Glu Cys Ala Thr His Phe Val 
            100                 105                 110         


Arg Ile Lys Ser Leu Val Asp Asp Ala Lys Phe Pro Glu Pro Asn Phe 
        115                 120                 125             


Trp Ser Asn Trp Ser Ser Trp Glu Glu Val Ser Val Gln Asp Ser Thr 
    130                 135                 140                 


Gly Gln Asp Ile Leu Phe Val Phe Pro Lys Asp Lys Leu Val Glu Glu 
145                 150                 155                 160 


Gly Thr Asn Val Thr Ile Cys Tyr Val Ser Arg Asn Ile Gln Asn Asn 
                165                 170                 175     


Val Ser Cys Tyr Leu Glu Gly Lys Gln Ile His Gly Glu Gln Leu Asp 
            180                 185                 190         


Pro His Val Thr Ala Phe Asn Leu Asn Ser Val Pro Phe Ile Arg Asn 
        195                 200                 205             


Lys Gly Thr Asn Ile Tyr Cys Glu Ala Ser Gln Gly Asn Val Ser Glu 
    210                 215                 220                 


Gly Met Lys Gly Ile Val Leu Phe Val Ser Lys Val Leu Glu Glu Pro 
225                 230                 235                 240 


Lys Asp Phe Ser Cys Glu Thr Glu Asp Phe Lys Thr Leu His Cys Thr 
                245                 250                 255     


Trp Asp Pro Gly Thr Asp Thr Ala Leu Gly Trp Ser Lys Gln Pro Ser 
            260                 265                 270         


Gln Ser Tyr Thr Leu Phe Glu Ser Phe Ser Gly Glu Lys Lys Leu Cys 
        275                 280                 285             


Thr His Lys Asn Trp Cys Asn Trp Gln Ile Thr Gln Asp Ser Gln Glu 
    290                 295                 300                 


Thr Tyr Asn Phe Thr Leu Ile Ala Glu Asn Tyr Leu Arg Lys Arg Ser 
305                 310                 315                 320 


Val Asn Ile Leu Phe Asn Leu Thr His Arg Val Tyr Leu Met Asn Pro 
                325                 330                 335     


Phe Ser Val Asn Phe Glu Asn Val Asn Ala Thr Asn Ala Ile Met Thr 
            340                 345                 350         


Trp Lys Val His Ser Ile Arg Asn Asn Phe Thr Tyr Leu Cys Gln Ile 
        355                 360                 365             


Glu Leu His Gly Glu Gly Lys Met Met Gln Tyr Asn Val Ser Ile Lys 
    370                 375                 380                 


Val Asn Gly Glu Tyr Phe Leu Ser Glu Leu Glu Pro Ala Thr Glu Tyr 
385                 390                 395                 400 


Met Ala Arg Val Arg Cys Ala Asp Ala Ser His Phe Trp Lys Trp Ser 
                405                 410                 415     


Glu Trp Ser Gly Gln Asn Phe Thr Thr Leu Glu Ala Ala Pro Ser Glu 
            420                 425                 430         


Ala Pro Asp Val Trp Arg Ile Val Ser Leu Glu Pro Gly Asn His Thr 
        435                 440                 445             


Val Thr Leu Phe Trp Lys Pro Leu Ser Lys Leu His Ala Asn Gly Lys 
    450                 455                 460                 


Ile Leu Phe Tyr Asn Val Val Val Glu Asn Leu Asp Lys Pro Ser Ser 
465                 470                 475                 480 


Ser Glu Leu His Ser Ile Pro Ala Pro Ala Asn Ser Thr Lys Leu Ile 
                485                 490                 495     


Leu Asp Arg Cys Ser Tyr Gln Ile Cys Val Ile Ala Asn Asn Ser Val 
            500                 505                 510         


Gly Ala Ser Pro Ala Ser Val Ile Val Ile Ser Ala Asp Pro Glu Asn 
        515                 520                 525             


Lys Glu Val Glu Glu Glu Arg Ile Ala Gly Thr Glu Gly Gly Phe Ser 
    530                 535                 540                 


Leu Ser Trp Lys Pro Gln Pro Gly Asp Val Ile Gly Tyr Val Val Asp 
545                 550                 555                 560 


Trp Cys Asp His Thr Gln Asp Val Leu Gly Asp Phe Gln Trp Lys Asn 
                565                 570                 575     


Val Gly Pro Asn Thr Thr Ser Thr Val Ile Ser Thr Asp Ala Phe Arg 
            580                 585                 590         


Pro Gly Val Arg Tyr Asp Phe Arg Ile Tyr Gly Leu Ser Thr Lys Arg 
        595                 600                 605             


Ile Ala Cys Leu Leu Glu Lys Lys Thr Gly Tyr Ser Gln Glu Leu Ala 
    610                 615                 620                 


Pro Ser Asp Asn Pro His Val Leu Val Asp Thr Leu Thr Ser His Ser 
625                 630                 635                 640 


Phe Thr Leu Ser Trp Lys Asp Tyr Ser Thr Glu Ser Gln Pro Gly Phe 
                645                 650                 655     


Ile Gln Gly Tyr His Val Tyr Leu Lys Ser Lys Ala Arg Gln Cys His 
            660                 665                 670         


Pro Arg Phe Glu Lys Ala Val Leu Ser Asp Gly Ser Glu Cys Cys Lys 
        675                 680                 685             


Tyr Lys Ile Asp Asn Pro Glu Glu Lys Ala Leu Ile Val Asp Asn Leu 
    690                 695                 700                 


Lys Pro Glu Ser Phe Tyr Glu Phe Phe Ile Thr Pro Phe Thr Ser Ala 
705                 710                 715                 720 


Gly Glu Gly Pro Ser Ala Thr Phe Thr Lys Val Thr Thr Pro Asp Glu 
                725                 730                 735     


His Ser Ser Met Leu Ile His Ile Leu Leu Pro Met Val Phe Cys Val 
            740                 745                 750         


Leu Leu Ile Met Val Met Cys Tyr Leu Lys Ser Gln Trp Ile Lys Glu 
        755                 760                 765             


Thr Cys Tyr Pro Asp Ile Pro Asp Pro Tyr Lys Ser Ser Ile Leu Ser 
    770                 775                 780                 


Leu Ile Lys Phe Lys Glu Asn Pro His Leu Ile Ile Met Asn Val Ser 
785                 790                 795                 800 


Asp Cys Ile Pro Asp Ala Ile Glu Val Val Ser Lys Pro Glu Gly Thr 
                805                 810                 815     


Lys Ile Gln Phe Leu Gly Thr Arg Lys Ser Leu Thr Glu Thr Glu Leu 
            820                 825                 830         


Thr Lys Pro Asn Tyr Leu Tyr Leu Leu Pro Thr Glu Lys Asn His Ser 
        835                 840                 845             


Gly Pro Gly Pro Cys Ile Cys Phe Glu Asn Leu Thr Tyr Asn Gln Ala 
    850                 855                 860                 


Ala Ser Asp Ser Gly Ser Cys Gly His Val Pro Val Ser Pro Lys Ala 
865                 870                 875                 880 


Pro Ser Met Leu Gly Leu Met Thr Ser Pro Glu Asn Val Leu Lys Ala 
                885                 890                 895     


Leu Glu Lys Asn Tyr Met Asn Ser Leu Gly Glu Ile Pro Ala Gly Glu 
            900                 905                 910         


Thr Ser Leu Asn Tyr Val Ser Gln Leu Ala Ser Pro Met Phe Gly Asp 
        915                 920                 925             


Lys Asp Ser Leu Pro Thr Asn Pro Val Glu Ala Pro His Cys Ser Glu 
    930                 935                 940                 


Tyr Lys Met Gln Met Ala Val Ser Leu Arg Leu Ala Leu Pro Pro Pro 
945                 950                 955                 960 


Thr Glu Asn Ser Ser Leu Ser Ser Ile Thr Leu Leu Asp Pro Gly Glu 
                965                 970                 975     


His Tyr Cys 
            


<210>  2944
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  2944

Met Gly Ala Thr Thr Met Asp Gln Lys Ser Leu Trp Ala Gly Val Val 
1               5                   10                  15      


Val Leu Leu Leu Leu Gln Gly Gly Ser Ala Tyr Lys Leu Val Cys Tyr 
            20                  25                  30          


Phe Thr Asn Trp Ser Gln Asp Arg Gln Glu Pro Gly Lys Phe Thr Pro 
        35                  40                  45              


Glu Asn Ile Asp Pro Phe Leu Cys Ser His Leu Ile Tyr Ser Phe Ala 
    50                  55                  60                  


Ser Ile Glu Asn Asn Lys Val Ile Ile Lys Asp Lys Ser Glu Val Met 
65                  70                  75                  80  


Leu Tyr Gln Thr Ile Asn Ser Leu Lys Thr Lys Asn Pro Lys Leu Lys 
                85                  90                  95      


Ile Leu Leu Ser Ile Gly Gly Tyr Leu Phe Gly Ser Lys Gly Phe His 
            100                 105                 110         


Pro Met Val Asp Ser Ser Thr Ser Arg Leu Glu Phe Ile Asn Ser Ile 
        115                 120                 125             


Ile Leu Phe Leu Arg Asn His Asn Phe Asp Gly Leu Asp Val Ser Trp 
    130                 135                 140                 


Ile Tyr Pro Asp Gln Lys Glu Asn Thr His Phe Thr Val Leu Ile His 
145                 150                 155                 160 


Glu Leu Ala Glu Ala Phe Gln Lys Asp Phe Thr Lys Ser Thr Lys Glu 
                165                 170                 175     


Arg Leu Leu Leu Thr Ala Gly Val Ser Ala Gly Arg Gln Met Ile Asp 
            180                 185                 190         


Asn Ser Tyr Gln Val Glu Lys Leu Ala Lys Asp Leu Asp Phe Ile Asn 
        195                 200                 205             


Leu Leu Ser Phe Asp Phe His Gly Ser Trp Glu Lys Pro Leu Ile Thr 
    210                 215                 220                 


Gly His Asn Ser Pro Leu Ser Lys Gly Trp Gln Asp Arg Gly Pro Ser 
225                 230                 235                 240 


Ser Tyr Tyr Asn Val Glu Tyr Ala Val Gly Tyr Trp Ile His Lys Gly 
                245                 250                 255     


Met Pro Ser Glu Lys Val Val Met Gly Ile Pro Thr Tyr Gly His Ser 
            260                 265                 270         


Phe Thr Leu Ala Ser Ala Glu Thr Thr Val Gly Ala Pro Ala Ser Gly 
        275                 280                 285             


Pro Gly Ala Ala Gly Pro Ile Thr Glu Ser Ser Gly Phe Leu Ala Tyr 
    290                 295                 300                 


Tyr Glu Ile Cys Gln Phe Leu Lys Gly Ala Lys Ile Thr Arg Leu Gln 
305                 310                 315                 320 


Asp Gln Gln Val Pro Tyr Ala Val Lys Gly Asn Gln Trp Val Gly Tyr 
                325                 330                 335     


Asp Asp Val Lys Ser Met Glu Thr Lys Val Gln Phe Leu Lys Asn Leu 
            340                 345                 350         


Asn Leu Gly Gly Ala Met Ile Trp Ser Ile Asp Met Asp Asp Phe Thr 
        355                 360                 365             


Gly Lys Ser Cys Asn Gln Gly Pro Tyr Pro Leu Val Gln Ala Val Lys 
    370                 375                 380                 


Arg Ser Leu Gly Ser Leu 
385                 390 


<210>  2945
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  2945

Met Gly Ile Leu Ser Phe Leu Pro Val Leu Ala Thr Glu Ser Asp Trp 
1               5                   10                  15      


Ala Asp Cys Lys Ser Pro Gln Pro Trp Gly His Met Leu Leu Trp Thr 
            20                  25                  30          


Ala Val Leu Phe Leu Ala Pro Val Ala Gly Thr Pro Ala Ala Pro Pro 
        35                  40                  45              


Lys Ala Val Leu Lys Leu Glu Pro Gln Trp Ile Asn Val Leu Gln Glu 
    50                  55                  60                  


Asp Ser Val Thr Leu Thr Cys Arg Gly Thr His Ser Pro Glu Ser Asp 
65                  70                  75                  80  


Ser Ile Gln Trp Phe His Asn Gly Asn Leu Ile Pro Thr His Thr Gln 
                85                  90                  95      


Pro Ser Tyr Arg Phe Lys Ala Asn Asn Asn Asp Ser Gly Glu Tyr Thr 
            100                 105                 110         


Cys Gln Thr Gly Gln Thr Ser Leu Ser Asp Pro Val His Leu Thr Val 
        115                 120                 125             


Leu Ser Glu Trp Leu Val Leu Gln Thr Pro His Leu Glu Phe Gln Glu 
    130                 135                 140                 


Gly Glu Thr Ile Val Leu Arg Cys His Ser Trp Lys Asp Lys Pro Leu 
145                 150                 155                 160 


Val Lys Val Thr Phe Phe Gln Asn Gly Lys Ser Lys Lys Phe Ser Arg 
                165                 170                 175     


Ser Asp Pro Asn Phe Ser Ile Pro Gln Ala Asn His Ser His Ser Gly 
            180                 185                 190         


Asp Tyr His Cys Thr Gly Asn Ile Gly Tyr Thr Leu Tyr Ser Ser Lys 
        195                 200                 205             


Pro Val Thr Ile Thr Val Gln Ala Pro Ser Ser Ser Pro Met Gly Ile 
    210                 215                 220                 


Ile Val Ala Val Val Thr Gly Ile Ala Val Ala Ala Ile Val Ala Ala 
225                 230                 235                 240 


Val Val Ala Leu Ile Tyr Cys Arg Lys Lys Arg Ile Ser Ala Leu Pro 
                245                 250                 255     


Gly Tyr Pro Glu Cys Arg Glu Met Gly Glu Thr Leu Pro Glu Lys Pro 
            260                 265                 270         


Ala Asn Pro Thr Asn Pro Asp Glu Ala Asp Lys Val Gly Ala Glu Asn 
        275                 280                 285             


Thr Ile Thr Tyr Ser Leu Leu Met His Pro Asp Ala Leu Glu Glu Pro 
    290                 295                 300                 


Asp Asp Gln Asn Arg Ile 
305                 310 


<210>  2946
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  2946

Met Asp Trp Gly Thr Leu Gln Thr Ile Leu Gly Gly Val Asn Lys His 
1               5                   10                  15      


Ser Thr Ser Ile Gly Lys Ile Trp Leu Thr Val Leu Phe Ile Phe Arg 
            20                  25                  30          


Ile Met Ile Leu Val Val Ala Ala Lys Glu Val Trp Gly Asp Glu Gln 
        35                  40                  45              


Ala Asp Phe Val Cys Asn Thr Leu Gln Pro Gly Cys Lys Asn Val Cys 
    50                  55                  60                  


Tyr Asp His Tyr Phe Pro Ile Ser His Ile Arg Leu Trp Ala Leu Gln 
65                  70                  75                  80  


Leu Ile Phe Val Ser Thr Pro Ala Leu Leu Val Ala Met His Val Ala 
                85                  90                  95      


Tyr Arg Arg His Glu Lys Lys Arg Lys Phe Ile Lys Gly Glu Ile Lys 
            100                 105                 110         


Ser Glu Phe Lys Asp Ile Glu Glu Ile Lys Thr Gln Lys Val Arg Ile 
        115                 120                 125             


Glu Gly Ser Leu Trp Trp Thr Tyr Thr Ser Ser Ile Phe Phe Arg Val 
    130                 135                 140                 


Ile Phe Glu Ala Ala Phe Met Tyr Val Phe Tyr Val Met Tyr Asp Gly 
145                 150                 155                 160 


Phe Ser Met Gln Arg Leu Val Lys Cys Asn Ala Trp Pro Cys Pro Asn 
                165                 170                 175     


Thr Val Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr Val Phe Thr 
            180                 185                 190         


Val Phe Met Ile Ala Val Ser Gly Ile Cys Ile Leu Leu Asn Val Thr 
        195                 200                 205             


Glu Leu Cys Tyr Leu Leu Ile Arg Tyr Cys Ser Gly Lys Ser Lys Lys 
    210                 215                 220                 


Pro Val 
225     


<210>  2947
<211>  938
<212>  PRT
<213>  Homo sapiens

<400>  2947

Met Thr Ala Arg Glu His Ser Pro Arg His Gly Ala Arg Ala Arg Ala 
1               5                   10                  15      


Met Gln Arg Ala Ser Thr Ile Asp Val Ala Ala Asp Met Leu Gly Leu 
            20                  25                  30          


Ser Leu Ala Gly Asn Ile Gln Asp Pro Asp Glu Pro Ile Leu Glu Phe 
        35                  40                  45              


Ser Leu Ala Cys Ser Glu Leu His Thr Pro Ser Leu Asp Arg Lys Pro 
    50                  55                  60                  


Asn Ser Phe Val Ala Val Ser Val Thr Thr Pro Pro Gln Ala Phe Trp 
65                  70                  75                  80  


Thr Lys His Ala Gln Thr Glu Ile Ile Glu Gly Thr Asn Asn Pro Ile 
                85                  90                  95      


Phe Leu Ser Ser Ile Ala Phe Phe Gln Asp Ser Leu Ile Asn Gln Met 
            100                 105                 110         


Thr Gln Val Lys Leu Ser Val Tyr Asp Val Lys Asp Arg Ser Gln Gly 
        115                 120                 125             


Thr Met Tyr Leu Leu Gly Ser Gly Thr Phe Ile Val Lys Asp Leu Leu 
    130                 135                 140                 


Gln Asp Arg His His Arg Leu His Leu Thr Leu Arg Ser Ala Glu Ser 
145                 150                 155                 160 


Asp Arg Val Gly Asn Ile Thr Val Ile Gly Trp Gln Met Glu Glu Lys 
                165                 170                 175     


Ser Asp Gln Arg Pro Pro Val Thr Arg Ser Val Asp Thr Val Asn Gly 
            180                 185                 190         


Arg Met Val Leu Pro Val Asp Glu Ser Leu Thr Glu Ala Leu Gly Ile 
        195                 200                 205             


Arg Ser Lys Tyr Ala Ser Leu Arg Lys Asp Thr Leu Leu Lys Ser Val 
    210                 215                 220                 


Phe Gly Gly Ala Ile Cys Arg Met Tyr Arg Phe Pro Thr Thr Asp Gly 
225                 230                 235                 240 


Asn His Leu Arg Ile Leu Glu Gln Met Ala Glu Ser Val Leu Ser Leu 
                245                 250                 255     


His Val Pro Arg Gln Phe Val Lys Leu Leu Leu Glu Glu Asp Ala Ala 
            260                 265                 270         


Arg Val Cys Glu Leu Glu Glu Leu Gly Glu Leu Ser Pro Cys Trp Glu 
        275                 280                 285             


Ser Leu Arg Arg Gln Ile Val Thr Gln Tyr Gln Thr Ile Ile Leu Thr 
    290                 295                 300                 


Tyr Gln Glu Asn Leu Thr Asp Leu His Gln Tyr Arg Gly Pro Ser Phe 
305                 310                 315                 320 


Lys Ala Ser Ser Leu Lys Ala Asp Lys Lys Leu Glu Phe Val Pro Thr 
                325                 330                 335     


Asn Leu His Ile Gln Arg Met Arg Val Gln Asp Asp Gly Gly Ser Asp 
            340                 345                 350         


Gln Asn Tyr Asp Ile Val Thr Ile Gly Ala Pro Ala Ala His Cys Gln 
        355                 360                 365             


Gly Phe Lys Ser Gly Gly Leu Arg Lys Lys Leu His Lys Phe Glu Glu 
    370                 375                 380                 


Thr Lys Lys His Phe Glu Glu Cys Cys Thr Ser Ser Gly Cys Gln Ser 
385                 390                 395                 400 


Ile Ile Tyr Ile Pro Gln Asp Val Val Arg Ala Lys Glu Ile Ile Ala 
                405                 410                 415     


Gln Ile Asn Thr Leu Lys Thr Gln Val Ser Tyr Tyr Ala Glu Arg Leu 
            420                 425                 430         


Ser Arg Ala Ala Lys Asp Arg Ser Ala Thr Gly Leu Glu Arg Thr Leu 
        435                 440                 445             


Ala Ile Leu Ala Asp Lys Thr Arg Gln Leu Val Thr Val Cys Asp Cys 
    450                 455                 460                 


Lys Leu Leu Ala Asn Ser Ile His Gly Leu Asn Ala Ala Arg Pro Asp 
465                 470                 475                 480 


Tyr Ile Ala Ser Lys Ala Ser Pro Thr Ser Thr Glu Glu Glu Gln Val 
                485                 490                 495     


Met Leu Arg Asn Asp Gln Asp Thr Leu Met Ala Arg Trp Thr Gly Arg 
            500                 505                 510         


Asn Ser Arg Ser Ser Leu Gln Val Asp Trp His Glu Glu Glu Trp Glu 
        515                 520                 525             


Lys Val Trp Leu Asn Val Asp Lys Ser Leu Glu Cys Ile Ile Gln Arg 
    530                 535                 540                 


Val Asp Lys Leu Leu Gln Lys Glu Arg Leu His Gly Glu Gly Cys Glu 
545                 550                 555                 560 


Asp Val Phe Pro Cys Ala Gly Ser Cys Thr Ser Lys Lys Asp Cys Ser 
                565                 570                 575     


Pro Pro Pro Glu Glu Ser Ser Pro Gly Glu Trp Ser Glu Ala Leu Tyr 
            580                 585                 590         


Pro Leu Leu Thr Thr Leu Thr Asp Cys Val Ala Met Met Ser Asp Lys 
        595                 600                 605             


Ala Lys Lys Ala Met Val Phe Leu Leu Met Gln Asp Ser Ala Pro Thr 
    610                 615                 620                 


Ile Ala Thr Tyr Leu Ser Leu Gln Tyr Arg Arg Asp Val Val Phe Cys 
625                 630                 635                 640 


Gln Thr Leu Thr Ala Leu Ile Cys Gly Phe Ile Ile Lys Leu Arg Asn 
                645                 650                 655     


Cys Leu His Asp Asp Gly Phe Leu Arg Gln Leu Tyr Thr Ile Gly Leu 
            660                 665                 670         


Leu Ala Gln Phe Glu Ser Leu Leu Ser Thr Tyr Gly Glu Glu Leu Ala 
        675                 680                 685             


Met Leu Glu Asp Met Ser Leu Gly Ile Met Asp Leu Arg Asn Val Thr 
    690                 695                 700                 


Phe Lys Val Thr Gln Ala Thr Ser Ser Ala Ser Ala Asp Met Leu Pro 
705                 710                 715                 720 


Val Ile Thr Gly Asn Arg Asp Gly Phe Asn Val Arg Val Pro Leu Pro 
                725                 730                 735     


Gly Pro Leu Phe Asp Ala Leu Pro Arg Glu Ile Gln Ser Gly Met Leu 
            740                 745                 750         


Leu Arg Val Gln Pro Val Leu Phe Asn Val Gly Ile Asn Glu Gln Gln 
        755                 760                 765             


Thr Leu Ala Glu Arg Phe Gly Asp Thr Ser Leu Gln Glu Val Ile Asn 
    770                 775                 780                 


Val Glu Ser Leu Val Arg Leu Asn Ser Tyr Phe Glu Gln Phe Lys Glu 
785                 790                 795                 800 


Val Leu Pro Glu Asp Cys Leu Pro Arg Ser Arg Ser Gln Thr Cys Leu 
                805                 810                 815     


Pro Glu Leu Leu Arg Phe Leu Gly Gln Asn Val His Ala Arg Lys Asn 
            820                 825                 830         


Lys Asn Val Asp Ile Leu Trp Gln Ala Ala Glu Ile Cys Arg Arg Leu 
        835                 840                 845             


Asn Gly Val Arg Phe Thr Ser Cys Lys Ser Ala Lys Asp Arg Thr Ala 
    850                 855                 860                 


Met Ser Val Thr Leu Glu Gln Cys Leu Ile Leu Gln His Glu His Gly 
865                 870                 875                 880 


Met Ala Pro Gln Val Phe Thr Gln Ala Leu Glu Cys Met Arg Ser Glu 
                885                 890                 895     


Gly Cys Arg Arg Glu Asn Thr Met Lys Asn Val Gly Ser Arg Lys Tyr 
            900                 905                 910         


Ala Phe Asn Ser Leu Gln Leu Lys Ala Phe Pro Lys His Tyr Arg Pro 
        915                 920                 925             


Pro Glu Gly Thr Tyr Gly Lys Val Glu Thr 
    930                 935             


<210>  2948
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  2948

Met Val Ala Phe Lys Gly Val Trp Thr Gln Ala Phe Trp Lys Ala Val 
1               5                   10                  15      


Thr Ala Glu Phe Leu Ala Met Leu Ile Phe Val Leu Leu Ser Leu Gly 
            20                  25                  30          


Ser Thr Ile Asn Trp Gly Gly Thr Glu Lys Pro Leu Pro Val Asp Met 
        35                  40                  45              


Val Leu Ile Ser Leu Cys Phe Gly Leu Ser Ile Ala Thr Met Val Gln 
    50                  55                  60                  


Cys Phe Gly His Ile Ser Gly Gly His Ile Asn Pro Ala Val Thr Val 
65                  70                  75                  80  


Ala Met Val Cys Thr Arg Lys Ile Ser Ile Ala Lys Ser Val Phe Tyr 
                85                  90                  95      


Ile Ala Ala Gln Cys Leu Gly Ala Ile Ile Gly Ala Gly Ile Leu Tyr 
            100                 105                 110         


Leu Val Thr Pro Pro Ser Val Val Gly Gly Leu Gly Val Thr Met Val 
        115                 120                 125             


His Gly Asn Leu Thr Ala Gly His Gly Leu Leu Val Glu Leu Ile Ile 
    130                 135                 140                 


Thr Phe Gln Leu Val Phe Thr Ile Phe Ala Ser Cys Asp Ser Lys Arg 
145                 150                 155                 160 


Thr Asp Val Thr Gly Ser Ile Ala Leu Ala Ile Gly Phe Ser Val Ala 
                165                 170                 175     


Ile Gly His Leu Phe Ala Ile Asn Tyr Thr Gly Ala Ser Met Asn Pro 
            180                 185                 190         


Ala Arg Ser Phe Gly Pro Ala Val Ile Met Gly Asn Trp Glu Asn His 
        195                 200                 205             


Trp Ile Tyr Trp Val Gly Pro Ile Ile Gly Ala Val Leu Ala Gly Gly 
    210                 215                 220                 


Leu Tyr Glu Tyr Val Phe Cys Pro Asp Val Glu Phe Lys Arg Arg Phe 
225                 230                 235                 240 


Lys Glu Ala Phe Ser Lys Ala Ala Gln Gln Thr Lys Gly Ser Tyr Met 
                245                 250                 255     


Glu Val Glu Asp Asn Arg Ser Gln Val Glu Thr Asp Asp Leu Ile Leu 
            260                 265                 270         


Lys Pro Gly Val Val His Val Ile Asp Val Asp Arg Gly Glu Glu Lys 
        275                 280                 285             


Lys Gly Lys Asp Gln Ser Gly Glu Val Leu Ser Ser Val 
    290                 295                 300     


<210>  2949
<211>  1144
<212>  PRT
<213>  Homo sapiens

<400>  2949

Met Pro Arg Asn Gln Gly Phe Ser Glu Pro Glu Tyr Ser Ala Glu Tyr 
1               5                   10                  15      


Ser Ala Glu Tyr Ser Val Ser Leu Pro Ser Asp Pro Asp Arg Gly Val 
            20                  25                  30          


Gly Arg Thr His Glu Ile Ser Val Arg Asn Ser Gly Ser Cys Leu Cys 
        35                  40                  45              


Leu Pro Arg Phe Met Arg Leu Thr Phe Val Pro Glu Ser Leu Glu Asn 
    50                  55                  60                  


Leu Tyr Gln Thr Tyr Phe Lys Arg Gln Arg His Glu Thr Leu Leu Val 
65                  70                  75                  80  


Leu Val Val Phe Ala Ala Leu Phe Asp Cys Tyr Val Val Val Met Cys 
                85                  90                  95      


Ala Val Val Phe Ser Ser Asp Lys Leu Ala Ser Leu Ala Val Ala Gly 
            100                 105                 110         


Ile Gly Leu Val Leu Asp Ile Ile Leu Phe Val Leu Cys Lys Lys Gly 
        115                 120                 125             


Leu Leu Pro Asp Arg Val Thr Arg Arg Val Leu Pro Tyr Val Leu Trp 
    130                 135                 140                 


Leu Leu Ile Thr Ala Gln Ile Phe Ser Tyr Leu Gly Leu Asn Phe Ala 
145                 150                 155                 160 


Arg Ala His Ala Ala Ser Asp Thr Val Gly Trp Gln Val Phe Phe Val 
                165                 170                 175     


Phe Ser Phe Phe Ile Thr Leu Pro Leu Ser Leu Ser Pro Ile Val Ile 
            180                 185                 190         


Ile Ser Val Val Ser Cys Val Val His Thr Leu Val Leu Gly Val Thr 
        195                 200                 205             


Val Ala Gln Gln Gln Gln Glu Glu Leu Lys Gly Met Gln Leu Leu Arg 
    210                 215                 220                 


Glu Ile Leu Ala Asn Val Phe Leu Tyr Leu Cys Ala Ile Ala Val Gly 
225                 230                 235                 240 


Ile Met Ser Tyr Tyr Met Ala Asp Arg Lys His Arg Lys Ala Phe Leu 
                245                 250                 255     


Glu Ala Arg Gln Ser Leu Glu Val Lys Met Asn Leu Glu Glu Gln Ser 
            260                 265                 270         


Gln Gln Gln Glu Asn Leu Met Leu Ser Ile Leu Pro Lys His Val Ala 
        275                 280                 285             


Asp Glu Met Leu Lys Asp Met Lys Lys Asp Glu Ser Gln Lys Asp Gln 
    290                 295                 300                 


Gln Gln Phe Asn Thr Met Tyr Met Tyr Arg His Glu Asn Val Ser Ile 
305                 310                 315                 320 


Leu Phe Ala Asp Ile Val Gly Phe Thr Gln Leu Ser Ser Ala Cys Ser 
                325                 330                 335     


Ala Gln Glu Leu Val Lys Leu Leu Asn Glu Leu Phe Ala Arg Phe Asp 
            340                 345                 350         


Lys Leu Ala Ala Lys Tyr His Gln Leu Arg Ile Lys Ile Leu Gly Asp 
        355                 360                 365             


Cys Tyr Tyr Cys Ile Cys Gly Leu Pro Asp Tyr Arg Glu Asp His Ala 
    370                 375                 380                 


Val Cys Ser Ile Leu Met Gly Leu Ala Met Val Glu Ala Ile Ser Tyr 
385                 390                 395                 400 


Val Arg Glu Lys Thr Lys Thr Gly Val Asp Met Arg Val Gly Val His 
                405                 410                 415     


Thr Gly Thr Val Leu Gly Gly Val Leu Gly Gln Lys Arg Trp Gln Tyr 
            420                 425                 430         


Asp Val Trp Ser Thr Asp Val Thr Val Ala Asn Lys Met Glu Ala Gly 
        435                 440                 445             


Gly Ile Pro Gly Arg Val His Ile Ser Gln Ser Thr Met Asp Cys Leu 
    450                 455                 460                 


Lys Gly Glu Phe Asp Val Glu Pro Gly Asp Gly Gly Ser Arg Cys Asp 
465                 470                 475                 480 


Tyr Leu Glu Glu Lys Gly Ile Glu Thr Tyr Leu Ile Ile Ala Ser Lys 
                485                 490                 495     


Pro Glu Val Lys Lys Thr Ala Thr Gln Asn Gly Leu Asn Gly Ser Ala 
            500                 505                 510         


Leu Pro Asn Gly Ala Pro Ala Ser Ser Lys Ser Ser Ser Pro Ala Leu 
        515                 520                 525             


Ile Glu Thr Lys Glu Pro Asn Gly Ser Ala His Ser Ser Gly Ser Thr 
    530                 535                 540                 


Ser Glu Lys Pro Glu Glu Gln Asp Ala Gln Ala Asp Asn Pro Ser Phe 
545                 550                 555                 560 


Pro Asn Pro Arg Arg Arg Leu Arg Leu Gln Asp Leu Ala Asp Arg Val 
                565                 570                 575     


Val Asp Ala Ser Glu Asp Glu His Glu Leu Asn Gln Leu Leu Asn Glu 
            580                 585                 590         


Ala Leu Leu Glu Arg Glu Ser Ala Gln Val Val Lys Lys Arg Asn Thr 
        595                 600                 605             


Phe Leu Leu Ser Met Arg Phe Met Asp Pro Glu Met Glu Thr Arg Tyr 
    610                 615                 620                 


Ser Val Glu Lys Glu Lys Gln Ser Gly Ala Ala Phe Ser Cys Ser Cys 
625                 630                 635                 640 


Val Val Leu Leu Cys Thr Ala Leu Val Glu Ile Leu Ile Asp Pro Trp 
                645                 650                 655     


Leu Met Thr Asn Tyr Val Thr Phe Met Val Gly Glu Ile Leu Leu Leu 
            660                 665                 670         


Ile Leu Thr Ile Cys Ser Leu Ala Ala Ile Phe Pro Arg Ala Phe Pro 
        675                 680                 685             


Lys Lys Leu Val Ala Phe Ser Thr Trp Ile Asp Arg Thr Arg Trp Ala 
    690                 695                 700                 


Arg Asn Thr Trp Ala Met Leu Ala Ile Phe Ile Leu Val Met Ala Asn 
705                 710                 715                 720 


Val Val Asp Met Leu Ser Cys Leu Gln Tyr Tyr Thr Gly Pro Ser Asn 
                725                 730                 735     


Ala Thr Ala Gly Met Glu Thr Glu Gly Ser Cys Leu Glu Asn Pro Lys 
            740                 745                 750         


Tyr Tyr Asn Tyr Val Ala Val Leu Ser Leu Ile Ala Thr Ile Met Leu 
        755                 760                 765             


Val Gln Val Ser His Met Val Lys Leu Thr Leu Met Leu Leu Val Ala 
    770                 775                 780                 


Gly Ala Val Ala Thr Ile Asn Leu Tyr Ala Trp Arg Pro Val Phe Asp 
785                 790                 795                 800 


Glu Tyr Asp His Lys Arg Phe Arg Glu His Asp Leu Pro Met Val Ala 
                805                 810                 815     


Leu Glu Gln Met Gln Gly Phe Asn Pro Gly Leu Asn Gly Thr Asp Arg 
            820                 825                 830         


Leu Pro Leu Val Pro Ser Lys Tyr Ser Met Thr Val Met Val Phe Leu 
        835                 840                 845             


Met Met Leu Ser Phe Tyr Tyr Phe Ser Arg His Val Glu Lys Leu Ala 
    850                 855                 860                 


Arg Thr Leu Phe Leu Trp Lys Ile Glu Val His Asp Gln Lys Glu Arg 
865                 870                 875                 880 


Val Tyr Glu Met Arg Arg Trp Asn Glu Ala Leu Val Thr Asn Met Leu 
                885                 890                 895     


Pro Glu His Val Ala Arg His Phe Leu Gly Ser Lys Lys Arg Asp Glu 
            900                 905                 910         


Glu Leu Tyr Ser Gln Thr Tyr Asp Glu Ile Gly Val Met Phe Ala Ser 
        915                 920                 925             


Leu Pro Asn Phe Ala Asp Phe Tyr Thr Glu Glu Ser Ile Asn Asn Gly 
    930                 935                 940                 


Gly Ile Glu Cys Leu Arg Phe Leu Asn Glu Ile Ile Ser Asp Phe Asp 
945                 950                 955                 960 


Ser Leu Leu Asp Asn Pro Lys Phe Arg Val Ile Thr Lys Ile Lys Thr 
                965                 970                 975     


Ile Gly Ser Thr Tyr Met Ala Ala Ser Gly Val Thr Pro Asp Val Asn 
            980                 985                 990         


Thr Asn Gly Phe Ala Ser Ser Asn  Lys Glu Asp Lys Ser  Glu Arg Glu 
        995                 1000                 1005             


Arg Trp  Gln His Leu Ala Asp  Leu Ala Asp Phe Ala  Leu Ala Met 
    1010                 1015                 1020             


Lys Asp  Thr Leu Thr Asn Ile  Asn Asn Gln Ser Phe  Asn Asn Phe 
    1025                 1030                 1035             


Met Leu  Arg Ile Gly Met Asn  Lys Gly Gly Val Leu  Ala Gly Val 
    1040                 1045                 1050             


Ile Gly  Ala Arg Lys Pro His  Tyr Asp Ile Trp Gly  Asn Thr Val 
    1055                 1060                 1065             


Asn Val  Ala Ser Arg Met Glu  Ser Thr Gly Val Met  Gly Asn Ile 
    1070                 1075                 1080             


Gln Val  Val Glu Glu Thr Gln  Val Ile Leu Arg Glu  Tyr Gly Phe 
    1085                 1090                 1095             


Arg Phe  Val Arg Arg Gly Pro  Ile Phe Val Lys Gly  Lys Gly Glu 
    1100                 1105                 1110             


Leu Leu  Thr Phe Phe Leu Lys  Gly Arg Asp Lys Leu  Ala Thr Phe 
    1115                 1120                 1125             


Pro Asn  Gly Pro Ser Val Thr  Leu Pro His Gln Val  Val Asp Asn 
    1130                 1135                 1140             


Ser 
    


<210>  2950
<211>  590
<212>  PRT
<213>  Homo sapiens

<400>  2950

Met Arg Pro Arg Arg Pro Leu Val Phe Met Ser Leu Val Cys Ala Leu 
1               5                   10                  15      


Leu Asn Thr Cys Gln Ala His Arg Val His Asp Asp Lys Pro Asn Ile 
            20                  25                  30          


Val Leu Ile Met Val Asp Asp Leu Gly Ile Gly Asp Leu Gly Cys Tyr 
        35                  40                  45              


Gly Asn Asp Thr Met Arg Thr Pro His Ile Asp Arg Leu Ala Arg Glu 
    50                  55                  60                  


Gly Val Arg Leu Thr Gln His Ile Ser Ala Ala Ser Leu Cys Ser Pro 
65                  70                  75                  80  


Ser Arg Ser Ala Phe Leu Thr Gly Arg Tyr Pro Ile Arg Ser Gly Met 
                85                  90                  95      


Val Ser Ser Gly Asn Arg Arg Val Ile Gln Asn Leu Ala Val Pro Ala 
            100                 105                 110         


Gly Leu Pro Leu Asn Glu Thr Thr Leu Ala Ala Leu Leu Lys Lys Gln 
        115                 120                 125             


Gly Tyr Ser Thr Gly Leu Ile Gly Lys Trp His Gln Gly Leu Asn Cys 
    130                 135                 140                 


Asp Ser Arg Ser Asp Gln Cys His His Pro Tyr Asn Tyr Gly Phe Asp 
145                 150                 155                 160 


Tyr Tyr Tyr Gly Met Pro Phe Thr Leu Val Asp Ser Cys Trp Pro Asp 
                165                 170                 175     


Pro Ser Arg Asn Thr Glu Leu Ala Phe Glu Ser Gln Leu Trp Leu Cys 
            180                 185                 190         


Val Gln Leu Val Ala Ile Ala Ile Leu Thr Leu Thr Phe Gly Lys Leu 
        195                 200                 205             


Ser Gly Trp Val Ser Val Pro Trp Leu Leu Ile Phe Ser Met Ile Leu 
    210                 215                 220                 


Phe Ile Phe Leu Leu Gly Tyr Ala Trp Phe Ser Ser His Thr Ser Pro 
225                 230                 235                 240 


Leu Tyr Trp Asp Cys Leu Leu Met Arg Gly His Glu Ile Thr Glu Gln 
                245                 250                 255     


Pro Met Lys Ala Glu Arg Ala Gly Ser Ile Met Val Lys Glu Ala Ile 
            260                 265                 270         


Ser Phe Leu Glu Arg His Ser Lys Glu Thr Phe Leu Leu Phe Phe Ser 
        275                 280                 285             


Phe Leu His Val His Thr Pro Leu Pro Thr Thr Asp Asp Phe Thr Gly 
    290                 295                 300                 


Thr Ser Lys His Gly Leu Tyr Gly Asp Asn Val Glu Glu Met Asp Ser 
305                 310                 315                 320 


Met Val Gly Lys Ile Leu Asp Ala Ile Asp Asp Phe Gly Leu Arg Asn 
                325                 330                 335     


Asn Thr Leu Val Tyr Phe Thr Ser Asp His Gly Gly His Leu Glu Ala 
            340                 345                 350         


Arg Arg Gly His Ala Gln Leu Gly Gly Trp Asn Gly Ile Tyr Lys Gly 
        355                 360                 365             


Gly Lys Gly Met Gly Gly Trp Glu Gly Gly Ile Arg Val Pro Gly Ile 
    370                 375                 380                 


Val Arg Trp Pro Gly Lys Val Pro Ala Gly Arg Leu Ile Lys Glu Pro 
385                 390                 395                 400 


Thr Ser Leu Met Asp Ile Leu Pro Thr Val Ala Ser Val Ser Gly Gly 
                405                 410                 415     


Ser Leu Pro Gln Asp Arg Val Ile Asp Gly Arg Asp Leu Met Pro Leu 
            420                 425                 430         


Leu Gln Gly Asn Val Arg His Ser Glu His Glu Phe Leu Phe His Tyr 
        435                 440                 445             


Cys Gly Ser Tyr Leu His Ala Val Arg Trp Ile Pro Lys Asp Asp Ser 
    450                 455                 460                 


Gly Ser Val Trp Lys Ala His Tyr Val Thr Pro Val Phe Gln Pro Pro 
465                 470                 475                 480 


Ala Ser Gly Gly Cys Tyr Val Thr Ser Leu Cys Arg Cys Phe Gly Glu 
                485                 490                 495     


Gln Val Thr Tyr His Asn Pro Pro Leu Leu Phe Asp Leu Ser Arg Asp 
            500                 505                 510         


Pro Ser Glu Ser Thr Pro Leu Thr Pro Ala Thr Glu Pro Leu His Asp 
        515                 520                 525             


Phe Val Ile Lys Lys Val Ala Asn Ala Leu Lys Glu His Gln Glu Thr 
    530                 535                 540                 


Ile Val Pro Val Thr Tyr Gln Leu Ser Glu Leu Asn Gln Gly Arg Thr 
545                 550                 555                 560 


Trp Leu Lys Pro Cys Cys Gly Val Phe Pro Phe Cys Leu Cys Asp Lys 
                565                 570                 575     


Glu Glu Glu Val Ser Gln Pro Arg Gly Pro Asn Glu Lys Arg 
            580                 585                 590 


<210>  2951
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  2951

Met Thr Gly Leu Ala Leu Leu Tyr Ser Gly Val Phe Val Ala Phe Trp 
1               5                   10                  15      


Ala Cys Ala Leu Ala Val Gly Val Cys Tyr Thr Ile Phe Asp Leu Gly 
            20                  25                  30          


Phe Arg Phe Asp Val Ala Trp Phe Leu Thr Glu Thr Ser Pro Phe Met 
        35                  40                  45              


Trp Ser Asn Leu Gly Ile Gly Leu Ala Ile Ser Leu Ser Val Val Gly 
    50                  55                  60                  


Ala Ala Trp Gly Ile Tyr Ile Thr Gly Ser Ser Ile Ile Gly Gly Gly 
65                  70                  75                  80  


Val Lys Ala Pro Arg Ile Lys Thr Lys Asn Leu Val Ser Ile Ile Phe 
                85                  90                  95      


Cys Glu Ala Val Ala Ile Tyr Gly Ile Ile Met Ala Ile Val Ile Ser 
            100                 105                 110         


Asn Met Ala Glu Pro Phe Ser Ala Thr Asp Pro Lys Ala Ile Gly His 
        115                 120                 125             


Arg Asn Tyr His Ala Gly Tyr Ser Met Phe Gly Ala Gly Leu Thr Val 
    130                 135                 140                 


Gly Leu Ser Asn Leu Phe Cys Gly Val Cys Val Gly Ile Val Gly Ser 
145                 150                 155                 160 


Gly Ala Ala Leu Ala Asp Ala Gln Asn Pro Ser Leu Phe Val Lys Ile 
                165                 170                 175     


Leu Ile Val Glu Ile Phe Gly Ser Ala Ile Gly Leu Phe Gly Val Ile 
            180                 185                 190         


Val Ala Ile Leu Gln Thr Ser Arg Val Lys Met Gly Asp 
        195                 200                 205 


<210>  2952
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  2952

Met Ala Thr Pro Ala Ser Ala Pro Asp Thr Arg Ala Leu Val Ala Asp 
1               5                   10                  15      


Phe Val Gly Tyr Lys Leu Arg Gln Lys Gly Tyr Val Cys Gly Ala Gly 
            20                  25                  30          


Pro Gly Glu Gly Pro Ala Ala Asp Pro Leu His Gln Ala Met Arg Ala 
        35                  40                  45              


Ala Gly Asp Glu Phe Glu Thr Arg Phe Arg Arg Thr Phe Ser Asp Leu 
    50                  55                  60                  


Ala Ala Gln Leu His Val Thr Pro Gly Ser Ala Gln Gln Arg Phe Thr 
65                  70                  75                  80  


Gln Val Ser Asp Glu Leu Phe Gln Gly Gly Pro Asn Trp Gly Arg Leu 
                85                  90                  95      


Val Ala Phe Phe Val Phe Gly Ala Ala Leu Cys Ala Glu Ser Val Asn 
            100                 105                 110         


Lys Glu Met Glu Pro Leu Val Gly Gln Val Gln Glu Trp Met Val Ala 
        115                 120                 125             


Tyr Leu Glu Thr Arg Leu Ala Asp Trp Ile His Ser Ser Gly Gly Trp 
    130                 135                 140                 


Ala Glu Phe Thr Ala Leu Tyr Gly Asp Gly Ala Leu Glu Glu Ala Arg 
145                 150                 155                 160 


Arg Leu Arg Glu Gly Asn Trp Ala Ser Val Arg Thr Val Leu Thr Gly 
                165                 170                 175     


Ala Val Ala Leu Gly Ala Leu Val Thr Val Gly Ala Phe Phe Ala Ser 
            180                 185                 190         


Lys 
    


<210>  2953
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  2953

Met Gly Asp Ala Ala Ala Asp Pro Pro Gly Pro Ala Leu Pro Cys Glu 
1               5                   10                  15      


Phe Leu Arg Pro Gly Cys Gly Ala Pro Leu Ser Pro Gly Ala Gln Leu 
            20                  25                  30          


Gly Arg Gly Ala Pro Thr Ser Ala Phe Pro Pro Pro Ala Ala Glu Ala 
        35                  40                  45              


His Pro Ala Ala Arg Arg Gly Leu Arg Ser Pro Gln Leu Pro Ser Gly 
    50                  55                  60                  


Ala Met Ser Gln Asn Gly Ala Pro Gly Met Gln Glu Glu Ser Leu Gln 
65                  70                  75                  80  


Gly Ser Trp Val Glu Leu His Phe Ser Asn Asn Gly Asn Gly Gly Ser 
                85                  90                  95      


Val Pro Ala Ser Val Ser Ile Tyr Asn Gly Asp Met Glu Lys Ile Leu 
            100                 105                 110         


Leu Asp Ala Gln His Glu Ser Gly Arg Ser Ser Ser Lys Ser Ser His 
        115                 120                 125             


Cys Asp Ser Pro Pro Arg Ser Gln Thr Pro Gln Asp Thr Asn Arg Ala 
    130                 135                 140                 


Ser Glu Thr Asp Thr His Ser Ile Gly Glu Lys Asn Ser Ser Gln Ser 
145                 150                 155                 160 


Glu Glu Asp Asp Ile Glu Arg Arg Lys Glu Val Glu Ser Ile Leu Lys 
                165                 170                 175     


Lys Asn Ser Asp Trp Ile Trp Asp Trp Ser Ser Arg Pro Glu Asn Ile 
            180                 185                 190         


Pro Pro Lys Glu Phe Leu Phe Lys His Pro Lys Arg Thr Ala Thr Leu 
        195                 200                 205             


Ser Met Arg Asn Thr Ser Val Met Lys Lys Gly Gly Ile Phe Ser Ala 
    210                 215                 220                 


Glu Phe Leu Lys Val Phe Leu Pro Ser Leu Leu Leu Ser His Leu Leu 
225                 230                 235                 240 


Ala Ile Gly Leu Gly Ile Tyr Ile Gly Arg Arg Leu Thr Thr Ser Thr 
                245                 250                 255     


Ser Thr Phe 
            


<210>  2954
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  2954

Met Ala Ser Phe Ser Ala Glu Thr Asn Ser Thr Asp Leu Leu Ser Gln 
1               5                   10                  15      


Pro Trp Asn Glu Pro Pro Val Ile Leu Ser Met Val Ile Leu Ser Leu 
            20                  25                  30          


Thr Phe Leu Leu Gly Leu Pro Gly Asn Gly Leu Val Leu Trp Val Ala 
        35                  40                  45              


Gly Leu Lys Met Gln Arg Thr Val Asn Thr Ile Trp Phe Leu His Leu 
    50                  55                  60                  


Thr Leu Ala Asp Leu Leu Cys Cys Leu Ser Leu Pro Phe Ser Leu Ala 
65                  70                  75                  80  


His Leu Ala Leu Gln Gly Gln Trp Pro Tyr Gly Arg Phe Leu Cys Lys 
                85                  90                  95      


Leu Ile Pro Ser Ile Ile Val Leu Asn Met Phe Ala Ser Val Phe Leu 
            100                 105                 110         


Leu Thr Ala Ile Ser Leu Asp Arg Cys Leu Val Val Phe Lys Pro Ile 
        115                 120                 125             


Trp Cys Gln Asn His Arg Asn Val Gly Met Ala Cys Ser Ile Cys Gly 
    130                 135                 140                 


Cys Ile Trp Val Val Ala Phe Val Met Cys Ile Pro Val Phe Val Tyr 
145                 150                 155                 160 


Arg Glu Ile Phe Thr Thr Asp Asn His Asn Arg Cys Gly Tyr Lys Phe 
                165                 170                 175     


Gly Leu Ser Ser Ser Leu Asp Tyr Pro Asp Phe Tyr Gly Asp Pro Leu 
            180                 185                 190         


Glu Asn Arg Ser Leu Glu Asn Ile Val Gln Pro Pro Gly Glu Met Asn 
        195                 200                 205             


Asp Arg Leu Asp Pro Ser Ser Phe Gln Thr Asn Asp His Pro Trp Thr 
    210                 215                 220                 


Val Pro Thr Val Phe Gln Pro Gln Thr Phe Gln Arg Pro Ser Ala Asp 
225                 230                 235                 240 


Ser Leu Pro Arg Gly Ser Ala Arg Leu Thr Ser Gln Asn Leu Tyr Ser 
                245                 250                 255     


Asn Val Phe Lys Pro Ala Asp Val Val Ser Pro Lys Ile Pro Ser Gly 
            260                 265                 270         


Phe Pro Ile Glu Asp His Glu Thr Ser Pro Leu Asp Asn Ser Asp Ala 
        275                 280                 285             


Phe Leu Ser Thr His Leu Lys Leu Phe Pro Ser Ala Ser Ser Asn Ser 
    290                 295                 300                 


Phe Tyr Glu Ser Glu Leu Pro Gln Gly Phe Gln Asp Tyr Tyr Asn Leu 
305                 310                 315                 320 


Gly Gln Phe Thr Asp Asp Asp Gln Val Pro Thr Pro Leu Val Ala Ile 
                325                 330                 335     


Thr Ile Thr Arg Leu Val Val Gly Phe Leu Leu Pro Ser Val Ile Met 
            340                 345                 350         


Ile Ala Cys Tyr Ser Phe Ile Val Phe Arg Met Gln Arg Gly Arg Phe 
        355                 360                 365             


Ala Lys Ser Gln Ser Lys Thr Phe Arg Val Ala Val Val Val Val Ala 
    370                 375                 380                 


Val Phe Leu Val Cys Trp Thr Pro Tyr His Ile Phe Gly Val Leu Ser 
385                 390                 395                 400 


Leu Leu Thr Asp Pro Glu Thr Pro Leu Gly Lys Thr Leu Met Ser Trp 
                405                 410                 415     


Asp His Val Cys Ile Ala Leu Ala Ser Ala Asn Ser Cys Phe Asn Pro 
            420                 425                 430         


Phe Leu Tyr Ala Leu Leu Gly Lys Asp Phe Arg Lys Lys Ala Arg Gln 
        435                 440                 445             


Ser Ile Gln Gly Ile Leu Glu Ala Ala Phe Ser Glu Glu Leu Thr Arg 
    450                 455                 460                 


Ser Thr His Cys Pro Ser Asn Asn Val Ile Ser Glu Arg Asn Ser Thr 
465                 470                 475                 480 


Thr Val 
        


<210>  2955
<211>  794
<212>  PRT
<213>  Homo sapiens

<400>  2955

Met Leu Thr Arg Asn Cys Leu Ser Leu Leu Leu Trp Val Leu Phe Asp 
1               5                   10                  15      


Gly Gly Leu Leu Thr Pro Leu Gln Pro Gln Pro Gln Gln Thr Leu Ala 
            20                  25                  30          


Thr Glu Pro Arg Glu Asn Val Ile His Leu Pro Gly Gln Arg Ser His 
        35                  40                  45              


Phe Gln Arg Val Lys Arg Gly Trp Val Trp Asn Gln Phe Phe Val Leu 
    50                  55                  60                  


Glu Glu Tyr Val Gly Ser Glu Pro Gln Tyr Val Gly Lys Leu His Ser 
65                  70                  75                  80  


Asp Leu Asp Lys Gly Glu Gly Thr Val Lys Tyr Thr Leu Ser Gly Asp 
                85                  90                  95      


Gly Ala Gly Thr Val Phe Thr Ile Asp Glu Thr Thr Gly Asp Ile His 
            100                 105                 110         


Ala Ile Arg Ser Leu Asp Arg Glu Glu Lys Pro Phe Tyr Thr Leu Arg 
        115                 120                 125             


Ala Gln Ala Val Asp Ile Glu Thr Arg Lys Pro Leu Glu Pro Glu Ser 
    130                 135                 140                 


Glu Phe Ile Ile Lys Val Gln Asp Ile Asn Asp Asn Glu Pro Lys Phe 
145                 150                 155                 160 


Leu Asp Gly Pro Tyr Val Ala Thr Val Pro Glu Met Ser Pro Val Gly 
                165                 170                 175     


Ala Tyr Val Leu Gln Val Lys Ala Thr Asp Ala Asp Asp Pro Thr Tyr 
            180                 185                 190         


Gly Asn Ser Ala Arg Val Val Tyr Ser Ile Leu Gln Gly Gln Pro Tyr 
        195                 200                 205             


Phe Ser Ile Asp Pro Lys Thr Gly Val Ile Arg Thr Ala Leu Pro Asn 
    210                 215                 220                 


Met Asp Arg Glu Val Lys Glu Gln Tyr Gln Val Leu Ile Gln Ala Lys 
225                 230                 235                 240 


Asp Met Gly Gly Gln Leu Gly Gly Leu Ala Gly Thr Thr Ile Val Asn 
                245                 250                 255     


Ile Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Arg Phe Pro Lys Ser 
            260                 265                 270         


Ile Phe His Leu Lys Val Pro Glu Ser Ser Pro Ile Gly Ser Ala Ile 
        275                 280                 285             


Gly Arg Ile Arg Ala Val Asp Pro Asp Phe Gly Gln Asn Ala Glu Ile 
    290                 295                 300                 


Glu Tyr Asn Ile Val Pro Gly Asp Gly Gly Asn Leu Phe Asp Ile Val 
305                 310                 315                 320 


Thr Asp Glu Asp Thr Gln Glu Gly Val Ile Lys Leu Lys Lys Pro Leu 
                325                 330                 335     


Asp Phe Glu Thr Lys Lys Ala Tyr Thr Phe Lys Val Glu Ala Ser Asn 
            340                 345                 350         


Leu His Leu Asp His Arg Phe His Ser Ala Gly Pro Phe Lys Asp Thr 
        355                 360                 365             


Ala Thr Val Lys Ile Ser Val Leu Asp Val Asp Glu Pro Pro Val Phe 
    370                 375                 380                 


Ser Lys Pro Leu Tyr Thr Met Glu Val Tyr Glu Asp Thr Pro Val Gly 
385                 390                 395                 400 


Thr Ile Ile Gly Ala Val Thr Ala Gln Asp Leu Asp Val Gly Ser Ser 
                405                 410                 415     


Ala Val Arg Tyr Phe Ile Asp Trp Lys Ser Asp Gly Asp Ser Tyr Phe 
            420                 425                 430         


Thr Ile Asp Gly Asn Glu Gly Thr Ile Ala Thr Asn Glu Leu Leu Asp 
        435                 440                 445             


Arg Glu Ser Thr Ala Gln Tyr Asn Phe Ser Ile Ile Ala Ser Lys Val 
    450                 455                 460                 


Ser Asn Pro Leu Leu Thr Ser Lys Val Asn Ile Leu Ile Asn Val Leu 
465                 470                 475                 480 


Asp Val Asn Glu Phe Pro Pro Glu Ile Ser Val Pro Tyr Glu Thr Ala 
                485                 490                 495     


Val Cys Glu Asn Ala Lys Pro Gly Gln Ile Ile Gln Ile Val Ser Ala 
            500                 505                 510         


Ala Asp Arg Asp Leu Ser Pro Ala Gly Gln Gln Phe Ser Phe Arg Leu 
        515                 520                 525             


Ser Pro Glu Ala Ala Ile Lys Pro Asn Phe Thr Val Arg Asp Phe Arg 
    530                 535                 540                 


Asn Asn Thr Ala Gly Ile Glu Thr Arg Arg Asn Gly Tyr Ser Arg Arg 
545                 550                 555                 560 


Gln Gln Glu Leu Tyr Phe Leu Pro Val Val Ile Glu Asp Ser Ser Tyr 
                565                 570                 575     


Pro Val Gln Ser Ser Thr Asn Thr Met Thr Ile Arg Val Cys Arg Cys 
            580                 585                 590         


Asp Ser Asp Gly Thr Ile Leu Ser Cys Asn Val Glu Ala Ile Phe Leu 
        595                 600                 605             


Pro Val Gly Leu Ser Thr Gly Ala Leu Ile Ala Ile Leu Leu Cys Ile 
    610                 615                 620                 


Val Ile Leu Leu Ala Ile Val Val Leu Tyr Val Ala Leu Arg Arg Gln 
625                 630                 635                 640 


Lys Lys Lys Asp Thr Leu Met Thr Ser Lys Glu Asp Ile Arg Asp Asn 
                645                 650                 655     


Val Ile His Tyr Asp Asp Glu Gly Gly Gly Glu Glu Asp Thr Gln Ala 
            660                 665                 670         


Phe Asp Ile Gly Ala Leu Arg Asn Pro Lys Val Ile Glu Glu Asn Lys 
        675                 680                 685             


Ile Arg Arg Asp Ile Lys Pro Asp Ser Leu Cys Leu Pro Arg Gln Arg 
    690                 695                 700                 


Pro Pro Met Glu Asp Asn Thr Asp Ile Arg Asp Phe Ile His Gln Arg 
705                 710                 715                 720 


Leu Gln Glu Asn Asp Val Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu 
                725                 730                 735     


Ala Thr Tyr Ala Tyr Glu Gly Ser Gly Ser Val Ala Glu Ser Leu Ser 
            740                 745                 750         


Ser Ile Asp Ser Leu Thr Thr Glu Ala Asp Gln Asp Tyr Asp Tyr Leu 
        755                 760                 765             


Thr Asp Trp Gly Pro Arg Phe Lys Val Leu Ala Asp Met Phe Gly Glu 
    770                 775                 780                 


Glu Glu Ser Tyr Asn Pro Asp Lys Val Thr 
785                 790                 


<210>  2956
<211>  829
<212>  PRT
<213>  Homo sapiens

<400>  2956

Met Val Pro Ala Trp Leu Trp Leu Leu Cys Val Ser Val Pro Gln Ala 
1               5                   10                  15      


Leu Pro Lys Ala Gln Pro Ala Glu Leu Ser Val Glu Val Pro Glu Asn 
            20                  25                  30          


Tyr Gly Gly Asn Phe Pro Leu Tyr Leu Thr Lys Leu Pro Leu Pro Arg 
        35                  40                  45              


Glu Gly Ala Glu Gly Gln Ile Val Leu Ser Gly Asp Ser Gly Lys Ala 
    50                  55                  60                  


Thr Glu Gly Pro Phe Ala Met Asp Pro Asp Ser Gly Phe Leu Leu Val 
65                  70                  75                  80  


Thr Arg Ala Leu Asp Arg Glu Glu Gln Ala Glu Tyr Gln Leu Gln Val 
                85                  90                  95      


Thr Leu Glu Met Gln Asp Gly His Val Leu Trp Gly Pro Gln Pro Val 
            100                 105                 110         


Leu Val His Val Lys Asp Glu Asn Asp Gln Val Pro His Phe Ser Gln 
        115                 120                 125             


Ala Ile Tyr Arg Ala Arg Leu Ser Arg Gly Thr Arg Pro Gly Ile Pro 
    130                 135                 140                 


Phe Leu Phe Leu Glu Ala Ser Asp Arg Asp Glu Pro Gly Thr Ala Asn 
145                 150                 155                 160 


Ser Asp Leu Arg Phe His Ile Leu Ser Gln Ala Pro Ala Gln Pro Ser 
                165                 170                 175     


Pro Asp Met Phe Gln Leu Glu Pro Arg Leu Gly Ala Leu Ala Leu Ser 
            180                 185                 190         


Pro Lys Gly Ser Thr Ser Leu Asp His Ala Leu Glu Arg Thr Tyr Gln 
        195                 200                 205             


Leu Leu Val Gln Val Lys Asp Met Gly Asp Gln Ala Ser Gly His Gln 
    210                 215                 220                 


Ala Thr Ala Thr Val Glu Val Ser Ile Ile Glu Ser Thr Trp Val Ser 
225                 230                 235                 240 


Leu Glu Pro Ile His Leu Ala Glu Asn Leu Lys Val Leu Tyr Pro His 
                245                 250                 255     


His Met Ala Gln Val His Trp Ser Gly Gly Asp Val His Tyr His Leu 
            260                 265                 270         


Glu Ser His Pro Pro Gly Pro Phe Glu Val Asn Ala Glu Gly Asn Leu 
        275                 280                 285             


Tyr Val Thr Arg Glu Leu Asp Arg Glu Ala Gln Ala Glu Tyr Leu Leu 
    290                 295                 300                 


Gln Val Arg Ala Gln Asn Ser His Gly Glu Asp Tyr Ala Ala Pro Leu 
305                 310                 315                 320 


Glu Leu His Val Leu Val Met Asp Glu Asn Asp Asn Val Pro Ile Cys 
                325                 330                 335     


Pro Pro Arg Asp Pro Thr Val Ser Ile Pro Glu Leu Ser Pro Pro Gly 
            340                 345                 350         


Thr Glu Val Thr Arg Leu Ser Ala Glu Asp Ala Asp Ala Pro Gly Ser 
        355                 360                 365             


Pro Asn Ser His Val Val Tyr Gln Leu Leu Ser Pro Glu Pro Glu Asp 
    370                 375                 380                 


Gly Val Glu Gly Arg Ala Phe Gln Val Asp Pro Thr Ser Gly Ser Val 
385                 390                 395                 400 


Thr Leu Gly Val Leu Pro Leu Arg Ala Gly Gln Asn Ile Leu Leu Leu 
                405                 410                 415     


Val Leu Ala Met Asp Leu Ala Gly Ala Glu Gly Gly Phe Ser Ser Thr 
            420                 425                 430         


Cys Glu Val Glu Val Ala Val Thr Asp Ile Asn Asp His Ala Pro Glu 
        435                 440                 445             


Phe Ile Thr Ser Gln Ile Gly Pro Ile Ser Leu Pro Glu Asp Val Glu 
    450                 455                 460                 


Pro Gly Thr Leu Val Ala Met Leu Thr Ala Ile Asp Ala Asp Leu Glu 
465                 470                 475                 480 


Pro Ala Phe Arg Leu Met Asp Phe Ala Ile Glu Arg Gly Asp Thr Glu 
                485                 490                 495     


Gly Thr Phe Gly Leu Asp Trp Glu Pro Asp Ser Gly His Val Arg Leu 
            500                 505                 510         


Arg Leu Cys Lys Asn Leu Ser Tyr Glu Ala Ala Pro Ser His Glu Val 
        515                 520                 525             


Val Val Val Val Gln Ser Val Ala Lys Leu Val Gly Pro Gly Pro Gly 
    530                 535                 540                 


Pro Gly Ala Thr Ala Thr Val Thr Val Leu Val Glu Arg Val Met Pro 
545                 550                 555                 560 


Pro Pro Lys Leu Asp Gln Glu Ser Tyr Glu Ala Ser Val Pro Ile Ser 
                565                 570                 575     


Ala Pro Ala Gly Ser Phe Leu Leu Thr Ile Gln Pro Ser Asp Pro Ile 
            580                 585                 590         


Ser Arg Thr Leu Arg Phe Ser Leu Val Asn Asp Ser Glu Gly Trp Leu 
        595                 600                 605             


Cys Ile Glu Lys Phe Ser Gly Glu Val His Thr Ala Gln Ser Leu Gln 
    610                 615                 620                 


Gly Ala Gln Pro Gly Asp Thr Tyr Thr Val Leu Val Glu Ala Gln Asp 
625                 630                 635                 640 


Thr Asp Glu Pro Arg Leu Ser Ala Ser Ala Pro Leu Val Ile His Phe 
                645                 650                 655     


Leu Lys Ala Pro Pro Ala Pro Ala Leu Thr Leu Ala Pro Val Pro Ser 
            660                 665                 670         


Gln Tyr Leu Cys Thr Pro Arg Gln Asp His Gly Leu Ile Val Ser Gly 
        675                 680                 685             


Pro Ser Lys Asp Pro Asp Leu Ala Ser Gly His Gly Pro Tyr Ser Phe 
    690                 695                 700                 


Thr Leu Gly Pro Asn Pro Thr Val Gln Arg Asp Trp Arg Leu Gln Thr 
705                 710                 715                 720 


Leu Asn Gly Ser His Ala Tyr Leu Thr Leu Ala Leu His Trp Val Glu 
                725                 730                 735     


Pro Arg Glu His Ile Ile Pro Val Val Val Ser His Asn Ala Gln Met 
            740                 745                 750         


Trp Gln Leu Leu Val Arg Val Ile Val Cys Arg Cys Asn Val Glu Gly 
        755                 760                 765             


Gln Cys Met Arg Lys Val Gly Arg Met Lys Gly Met Pro Thr Lys Leu 
    770                 775                 780                 


Ser Ala Val Gly Ile Leu Val Gly Thr Leu Val Ala Ile Gly Ile Phe 
785                 790                 795                 800 


Leu Ile Leu Ile Phe Thr His Trp Thr Met Ser Arg Lys Lys Asp Pro 
                805                 810                 815     


Asp Gln Pro Ala Asp Ser Val Pro Leu Lys Ala Thr Val 
            820                 825                 


<210>  2957
<211>  832
<212>  PRT
<213>  Homo sapiens

<400>  2957

Met Ile Leu Gln Ala His Leu His Ser Leu Cys Leu Leu Met Leu Tyr 
1               5                   10                  15      


Leu Ala Thr Gly Tyr Gly Gln Glu Gly Lys Phe Ser Gly Pro Leu Lys 
            20                  25                  30          


Pro Met Thr Phe Ser Ile Tyr Glu Gly Gln Glu Pro Ser Gln Ile Ile 
        35                  40                  45              


Phe Gln Phe Lys Ala Asn Pro Pro Ala Val Thr Phe Glu Leu Thr Gly 
    50                  55                  60                  


Glu Thr Asp Asn Ile Phe Val Ile Glu Arg Glu Gly Leu Leu Tyr Tyr 
65                  70                  75                  80  


Asn Arg Ala Leu Asp Arg Glu Thr Arg Ser Thr His Asn Leu Gln Val 
                85                  90                  95      


Ala Ala Leu Asp Ala Asn Gly Ile Ile Val Glu Gly Pro Val Pro Ile 
            100                 105                 110         


Thr Ile Lys Val Lys Asp Ile Asn Asp Asn Arg Pro Thr Phe Leu Gln 
        115                 120                 125             


Ser Lys Tyr Glu Gly Ser Val Arg Gln Asn Ser Arg Pro Gly Lys Pro 
    130                 135                 140                 


Phe Leu Tyr Val Asn Ala Thr Asp Leu Asp Asp Pro Ala Thr Pro Asn 
145                 150                 155                 160 


Gly Gln Leu Tyr Tyr Gln Ile Val Ile Gln Leu Pro Met Ile Asn Asn 
                165                 170                 175     


Val Met Tyr Phe Gln Ile Asn Asn Lys Thr Gly Ala Ile Ser Leu Thr 
            180                 185                 190         


Arg Glu Gly Ser Gln Glu Leu Asn Pro Ala Lys Asn Pro Ser Tyr Asn 
        195                 200                 205             


Leu Val Ile Ser Val Lys Asp Met Gly Gly Gln Ser Glu Asn Ser Phe 
    210                 215                 220                 


Ser Asp Thr Thr Ser Val Asp Ile Ile Val Thr Glu Asn Ile Trp Lys 
225                 230                 235                 240 


Ala Pro Lys Pro Val Glu Met Val Glu Asn Ser Thr Asp Pro His Pro 
                245                 250                 255     


Ile Lys Ile Thr Gln Val Arg Trp Asn Asp Pro Gly Ala Gln Tyr Ser 
            260                 265                 270         


Leu Val Asp Lys Glu Lys Leu Pro Arg Phe Pro Phe Ser Ile Asp Gln 
        275                 280                 285             


Glu Gly Asp Ile Tyr Val Thr Gln Pro Leu Asp Arg Glu Glu Lys Asp 
    290                 295                 300                 


Ala Tyr Val Phe Tyr Ala Val Ala Lys Asp Glu Tyr Gly Lys Pro Leu 
305                 310                 315                 320 


Ser Tyr Pro Leu Glu Ile His Val Lys Val Lys Asp Ile Asn Asp Asn 
                325                 330                 335     


Pro Pro Thr Cys Pro Ser Pro Val Thr Val Phe Glu Val Gln Glu Asn 
            340                 345                 350         


Glu Arg Leu Gly Asn Ser Ile Gly Thr Leu Thr Ala His Asp Arg Asp 
        355                 360                 365             


Glu Glu Asn Thr Ala Asn Ser Phe Leu Asn Tyr Arg Ile Val Glu Gln 
    370                 375                 380                 


Thr Pro Lys Leu Pro Met Asp Gly Leu Phe Leu Ile Gln Thr Tyr Ala 
385                 390                 395                 400 


Gly Met Leu Gln Leu Ala Lys Gln Ser Leu Lys Lys Gln Asp Thr Pro 
                405                 410                 415     


Gln Tyr Asn Leu Thr Ile Glu Val Ser Asp Lys Asp Phe Lys Thr Leu 
            420                 425                 430         


Cys Phe Val Gln Ile Asn Val Ile Asp Ile Asn Asp Gln Ile Pro Ile 
        435                 440                 445             


Phe Glu Lys Ser Asp Tyr Gly Asn Leu Thr Leu Ala Glu Asp Thr Asn 
    450                 455                 460                 


Ile Gly Ser Thr Ile Leu Thr Ile Gln Ala Thr Asp Ala Asp Glu Pro 
465                 470                 475                 480 


Phe Thr Gly Ser Ser Lys Ile Leu Tyr His Ile Ile Lys Gly Asp Ser 
                485                 490                 495     


Glu Gly Arg Leu Gly Val Asp Thr Asp Pro His Thr Asn Thr Gly Tyr 
            500                 505                 510         


Val Ile Ile Lys Lys Pro Leu Asp Phe Glu Thr Ala Ala Val Ser Asn 
        515                 520                 525             


Ile Val Phe Lys Ala Glu Asn Pro Glu Pro Leu Val Phe Gly Val Lys 
    530                 535                 540                 


Tyr Asn Ala Ser Ser Phe Ala Lys Phe Thr Leu Ile Val Thr Asp Val 
545                 550                 555                 560 


Asn Glu Ala Pro Gln Phe Ser Gln His Val Phe Gln Ala Lys Val Ser 
                565                 570                 575     


Glu Asp Val Ala Ile Gly Thr Lys Val Gly Asn Val Thr Ala Lys Asp 
            580                 585                 590         


Pro Glu Gly Leu Asp Ile Ser Tyr Ser Leu Arg Gly Asp Thr Arg Gly 
        595                 600                 605             


Trp Leu Lys Ile Asp His Val Thr Gly Glu Ile Phe Ser Val Ala Pro 
    610                 615                 620                 


Leu Asp Arg Glu Ala Gly Ser Pro Tyr Arg Val Gln Val Val Ala Thr 
625                 630                 635                 640 


Glu Val Gly Gly Ser Ser Leu Ser Ser Val Ser Glu Phe His Leu Ile 
                645                 650                 655     


Leu Met Asp Val Asn Asp Asn Pro Pro Arg Leu Ala Lys Asp Tyr Thr 
            660                 665                 670         


Gly Leu Phe Phe Cys His Pro Leu Ser Ala Pro Gly Ser Leu Ile Phe 
        675                 680                 685             


Glu Ala Thr Asp Asp Asp Gln His Leu Phe Arg Gly Pro His Phe Thr 
    690                 695                 700                 


Phe Ser Leu Gly Ser Gly Ser Leu Gln Asn Asp Trp Glu Val Ser Lys 
705                 710                 715                 720 


Ile Asn Gly Thr His Ala Arg Leu Ser Thr Arg His Thr Glu Phe Glu 
                725                 730                 735     


Glu Arg Glu Tyr Val Val Leu Ile Arg Ile Asn Asp Gly Gly Arg Pro 
            740                 745                 750         


Pro Leu Glu Gly Ile Val Ser Leu Pro Val Thr Phe Cys Ser Cys Val 
        755                 760                 765             


Glu Gly Ser Cys Phe Arg Pro Ala Gly His Gln Thr Gly Ile Pro Thr 
    770                 775                 780                 


Val Gly Met Ala Val Gly Ile Leu Leu Thr Thr Leu Leu Val Ile Gly 
785                 790                 795                 800 


Ile Ile Leu Ala Val Val Phe Ile Arg Ile Lys Lys Asp Lys Gly Lys 
                805                 810                 815     


Asp Asn Val Glu Ser Ala Gln Ala Ser Glu Val Lys Pro Leu Arg Ser 
            820                 825                 830         


<210>  2958
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  2958

Met Glu Asp Glu Asp Tyr Asn Thr Ser Ile Ser Tyr Gly Asp Glu Tyr 
1               5                   10                  15      


Pro Asp Tyr Leu Asp Ser Ile Val Val Leu Glu Asp Leu Ser Pro Leu 
            20                  25                  30          


Glu Ala Arg Val Thr Arg Ile Phe Leu Val Val Val Tyr Ser Ile Val 
        35                  40                  45              


Cys Phe Leu Gly Ile Leu Gly Asn Gly Leu Val Ile Ile Ile Ala Thr 
    50                  55                  60                  


Phe Lys Met Lys Lys Thr Val Asn Met Val Trp Phe Leu Asn Leu Ala 
65                  70                  75                  80  


Val Ala Asp Phe Leu Phe Asn Val Phe Leu Pro Ile His Ile Thr Tyr 
                85                  90                  95      


Ala Ala Met Asp Tyr His Trp Val Phe Gly Thr Ala Met Cys Lys Ile 
            100                 105                 110         


Ser Asn Phe Leu Leu Ile His Asn Met Phe Thr Ser Val Phe Leu Leu 
        115                 120                 125             


Thr Ile Ile Ser Ser Asp Arg Cys Ile Ser Val Leu Leu Pro Val Trp 
    130                 135                 140                 


Ser Gln Asn His Arg Ser Val Arg Leu Ala Tyr Met Ala Cys Met Val 
145                 150                 155                 160 


Ile Trp Val Leu Ala Phe Phe Leu Ser Ser Pro Ser Leu Val Phe Arg 
                165                 170                 175     


Asp Thr Ala Asn Leu His Gly Lys Ile Ser Cys Phe Asn Asn Phe Ser 
            180                 185                 190         


Leu Ser Thr Pro Gly Ser Ser Ser Trp Pro Thr His Ser Gln Met Asp 
        195                 200                 205             


Pro Val Gly Tyr Ser Arg His Met Val Val Thr Val Thr Arg Phe Leu 
    210                 215                 220                 


Cys Gly Phe Leu Val Pro Val Leu Ile Ile Thr Ala Cys Tyr Leu Thr 
225                 230                 235                 240 


Ile Val Cys Lys Leu Gln Arg Asn Arg Leu Ala Lys Thr Lys Lys Pro 
                245                 250                 255     


Phe Lys Ile Ile Val Thr Ile Ile Ile Thr Phe Phe Leu Cys Trp Cys 
            260                 265                 270         


Pro Tyr His Thr Leu Asn Leu Leu Glu Leu His His Thr Ala Met Pro 
        275                 280                 285             


Gly Ser Val Phe Ser Leu Gly Leu Pro Leu Ala Thr Ala Leu Ala Ile 
    290                 295                 300                 


Ala Asn Ser Cys Met Asn Pro Ile Leu Tyr Val Phe Met Gly Gln Asp 
305                 310                 315                 320 


Phe Lys Lys Phe Lys Val Ala Leu Phe Ser Arg Leu Val Asn Ala Leu 
                325                 330                 335     


Ser Glu Asp Thr Gly His Ser Ser Tyr Pro Ser His Arg Ser Phe Thr 
            340                 345                 350         


Lys Met Ser Ser Met Asn Glu Arg Thr Ser Met Asn Glu Arg Glu Thr 
        355                 360                 365             


Gly Met Leu 
    370     


<210>  2959
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  2959

Met Ser Val Leu Thr Pro Leu Leu Leu Arg Gly Leu Thr Gly Ser Ala 
1               5                   10                  15      


Arg Arg Leu Pro Val Pro Arg Ala Lys Ile His Ser Leu Pro Pro Glu 
            20                  25                  30          


Gly Lys Leu Gly Ile Met Glu Leu Ala Val Gly Leu Thr Ser Cys Phe 
        35                  40                  45              


Val Thr Phe Leu Leu Pro Ala Gly Trp Ile Leu Ser His Leu Glu Thr 
    50                  55                  60                  


Tyr Arg Arg Pro Glu 
65                  


<210>  2960
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  2960

Met Asn Thr Glu Met Tyr Gln Thr Pro Met Glu Val Ala Val Tyr Gln 
1               5                   10                  15      


Leu His Asn Phe Ser Ile Ser Phe Phe Ser Ser Leu Leu Gly Gly Asp 
            20                  25                  30          


Val Val Ser Val Lys Leu Asp Asn Ser Ala Ser Gly Ala Ser Val Val 
        35                  40                  45              


Ala Ile Asp Asn Lys Ile Glu Gln Ala Met Asp Leu Val Lys Asn His 
    50                  55                  60                  


Leu Met Tyr Ala Val Arg Glu Glu Val Glu Ile Leu Lys Glu Gln Ile 
65                  70                  75                  80  


Arg Glu Leu Val Glu Lys Asn Ser Gln Leu Glu Arg Glu Asn Thr Leu 
                85                  90                  95      


Leu Lys Thr Leu Ala Ser Pro Glu Gln Leu Glu Lys Phe Gln Ser Cys 
            100                 105                 110         


Leu Ser Pro Glu Glu Pro Ala Pro Glu Ser Pro Gln Val Pro Glu Ala 
        115                 120                 125             


Pro Gly Gly Ser Ala Val 
    130                 


<210>  2961
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  2961

Met Ala Val Arg Arg Asp Ser Val Trp Lys Tyr Cys Trp Gly Val Leu 
1               5                   10                  15      


Met Val Leu Cys Arg Thr Ala Ile Ser Lys Ser Ile Val Leu Glu Pro 
            20                  25                  30          


Ile Tyr Trp Asn Ser Ser Asn Ser Lys Phe Leu Pro Gly Gln Gly Leu 
        35                  40                  45              


Val Leu Tyr Pro Gln Ile Gly Asp Lys Leu Asp Ile Ile Cys Pro Lys 
    50                  55                  60                  


Val Asp Ser Lys Thr Val Gly Gln Tyr Glu Tyr Tyr Lys Val Tyr Met 
65                  70                  75                  80  


Val Asp Lys Asp Gln Ala Asp Arg Cys Thr Ile Lys Lys Glu Asn Thr 
                85                  90                  95      


Pro Leu Leu Asn Cys Ala Lys Pro Asp Gln Asp Ile Lys Phe Thr Ile 
            100                 105                 110         


Lys Phe Gln Glu Phe Ser Pro Asn Leu Trp Gly Leu Glu Phe Gln Lys 
        115                 120                 125             


Asn Lys Asp Tyr Tyr Ile Ile Ser Thr Ser Asn Gly Ser Leu Glu Gly 
    130                 135                 140                 


Leu Asp Asn Gln Glu Gly Gly Val Cys Gln Thr Arg Ala Met Lys Ile 
145                 150                 155                 160 


Leu Met Lys Val Gly Gln Asp Ala Ser Ser Ala Gly Ser Thr Arg Asn 
                165                 170                 175     


Lys Asp Pro Thr Arg Arg Pro Glu Leu Glu Ala Gly Thr Asn Gly Arg 
            180                 185                 190         


Ser Ser Thr Thr Ser Pro Phe Val Lys Pro Asn Pro Gly Ser Ser Thr 
        195                 200                 205             


Asp Gly Asn Ser Ala Gly His Ser Gly Asn Asn Ile Leu Gly Ser Glu 
    210                 215                 220                 


Val Ala Leu Phe Ala Gly Ile Ala Ser Gly Cys Ile Ile Phe Ile Val 
225                 230                 235                 240 


Ile Ile Ile Thr Leu Val Val Leu Leu Leu Lys Tyr Arg Arg Arg His 
                245                 250                 255     


Arg Lys His Ser Pro Gln His Thr Thr Thr Leu Ser Leu Ser Thr Leu 
            260                 265                 270         


Ala Thr Pro Lys Arg Ser Gly Asn Asn Asn Gly Ser Glu Pro Ser Asp 
        275                 280                 285             


Ile Ile Ile Pro Leu Arg Thr Ala Asp Ser Val Phe Cys Pro His Tyr 
    290                 295                 300                 


Glu Lys Val Ser Gly Asp Tyr Gly His Pro Val Tyr Ile Val Gln Glu 
305                 310                 315                 320 


Met Pro Pro Gln Ser Pro Ala Asn Ile Tyr Tyr Lys Val 
                325                 330             


<210>  2962
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  2962

Met Ala Glu Lys Arg His Thr Arg Asp Ser Glu Ala Gln Arg Leu Pro 
1               5                   10                  15      


Asp Ser Phe Lys Asp Ser Pro Ser Lys Gly Leu Gly Pro Cys Gly Trp 
            20                  25                  30          


Ile Leu Val Ala Phe Ser Phe Leu Phe Thr Val Ile Thr Phe Pro Ile 
        35                  40                  45              


Ser Ile Trp Met Cys Ile Lys Ile Ile Lys Glu Tyr Glu Arg Ala Ile 
    50                  55                  60                  


Ile Phe Arg Leu Gly Arg Ile Leu Gln Gly Gly Ala Lys Gly Pro Gly 
65                  70                  75                  80  


Leu Phe Phe Ile Leu Pro Cys Thr Asp Ser Phe Ile Lys Val Asp Met 
                85                  90                  95      


Arg Thr Ile Ser Phe Asp Ile Pro Pro Gln Glu Ile Leu Thr Lys Asp 
            100                 105                 110         


Ser Val Thr Ile Ser Val Asp Gly Val Val Tyr Tyr Arg Val Gln Asn 
        115                 120                 125             


Ala Thr Leu Ala Val Ala Asn Ile Thr Asn Ala Asp Ser Ala Thr Arg 
    130                 135                 140                 


Leu Leu Ala Gln Thr Thr Leu Arg Asn Val Leu Gly Thr Lys Asn Leu 
145                 150                 155                 160 


Ser Gln Ile Leu Ser Asp Arg Glu Glu Ile Ala His Asn Met Gln Ser 
                165                 170                 175     


Thr Leu Asp Asp Ala Thr Asp Ala Trp Gly Ile Lys Val Glu Arg Val 
            180                 185                 190         


Glu Ile Lys Asp Val Lys Leu Pro Val Gln Leu Gln Arg Ala Met Ala 
        195                 200                 205             


Ala Glu Ala Glu Ala Ser Arg Glu Ala Arg Ala Lys Val Ile Ala Ala 
    210                 215                 220                 


Glu Gly Glu Met Asn Ala Ser Arg Ala Leu Lys Glu Ala Ser Met Val 
225                 230                 235                 240 


Ile Thr Glu Ser Pro Ala Ala Leu Gln Leu Arg Tyr Leu Gln Thr Leu 
                245                 250                 255     


Thr Thr Ile Ala Ala Glu Lys Asn Ser Thr Ile Val Phe Pro Leu Pro 
            260                 265                 270         


Ile Asp Met Leu Gln Gly Ile Ile Gly Ala Lys His Ser His Leu Gly 
        275                 280                 285             


<210>  2963
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  2963

Met Lys Ala Leu Ile Phe Ala Ala Ala Gly Leu Leu Leu Leu Leu Pro 
1               5                   10                  15      


Thr Phe Cys Gln Ser Gly Met Glu Asn Asp Thr Asn Asn Leu Ala Lys 
            20                  25                  30          


Pro Thr Leu Pro Ile Lys Thr Phe Arg Gly Ala Pro Pro Asn Ser Phe 
        35                  40                  45              


Glu Glu Phe Pro Phe Ser Ala Leu Glu Gly Trp Thr Gly Ala Thr Ile 
    50                  55                  60                  


Thr Val Lys Ile Lys Cys Pro Glu Glu Ser Ala Ser His Leu His Val 
65                  70                  75                  80  


Lys Asn Ala Thr Met Gly Tyr Leu Thr Ser Ser Leu Ser Thr Lys Leu 
                85                  90                  95      


Ile Pro Ala Ile Tyr Leu Leu Val Phe Val Val Gly Val Pro Ala Asn 
            100                 105                 110         


Ala Val Thr Leu Trp Met Leu Phe Phe Arg Thr Arg Ser Ile Cys Thr 
        115                 120                 125             


Thr Val Phe Tyr Thr Asn Leu Ala Ile Ala Asp Phe Leu Phe Cys Val 
    130                 135                 140                 


Thr Leu Pro Phe Lys Ile Ala Tyr His Leu Asn Gly Asn Asn Trp Val 
145                 150                 155                 160 


Phe Gly Glu Val Leu Cys Arg Ala Thr Thr Val Ile Phe Tyr Gly Asn 
                165                 170                 175     


Met Tyr Cys Ser Ile Leu Leu Leu Ala Cys Ile Ser Ile Asn Arg Tyr 
            180                 185                 190         


Leu Ala Ile Val His Pro Phe Thr Tyr Arg Gly Leu Pro Lys His Thr 
        195                 200                 205             


Tyr Ala Leu Val Thr Cys Gly Leu Val Trp Ala Thr Val Phe Leu Tyr 
    210                 215                 220                 


Met Leu Pro Phe Phe Ile Leu Lys Gln Glu Tyr Tyr Leu Val Gln Pro 
225                 230                 235                 240 


Asp Ile Thr Thr Cys His Asp Val His Asn Thr Cys Glu Ser Ser Ser 
                245                 250                 255     


Pro Phe Gln Leu Tyr Tyr Phe Ile Ser Leu Ala Phe Phe Gly Phe Leu 
            260                 265                 270         


Ile Pro Phe Val Leu Ile Ile Tyr Cys Tyr Ala Ala Ile Ile Arg Thr 
        275                 280                 285             


Leu Asn Ala Tyr Asp His Arg Trp Leu Trp Tyr Val Lys Ala Ser Leu 
    290                 295                 300                 


Leu Ile Leu Val Ile Phe Thr Ile Cys Phe Ala Pro Ser Asn Ile Ile 
305                 310                 315                 320 


Leu Ile Ile His His Ala Asn Tyr Tyr Tyr Asn Asn Thr Asp Gly Leu 
                325                 330                 335     


Tyr Phe Ile Tyr Leu Ile Ala Leu Cys Leu Gly Ser Leu Asn Ser Cys 
            340                 345                 350         


Leu Asp Pro Phe Leu Tyr Phe Leu Met Ser Lys Thr Arg Asn His Ser 
        355                 360                 365             


Thr Ala Tyr Leu Thr Lys 
    370                 


<210>  2964
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  2964

Met Ile Pro Ala Val Val Leu Leu Leu Leu Leu Leu Val Glu Gln Ala 
1               5                   10                  15      


Ala Ala Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile Leu 
            20                  25                  30          


Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile 
        35                  40                  45              


Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val 
    50                  55                  60                  


Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys 
65                  70                  75                  80  


His Glu Lys Pro Pro Gln 
                85      


<210>  2965
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  2965

Met Gly Val Pro Arg Pro Gln Pro Trp Ala Leu Gly Leu Leu Leu Phe 
1               5                   10                  15      


Leu Leu Pro Gly Ser Leu Gly Ala Glu Ser His Leu Ser Leu Leu Tyr 
            20                  25                  30          


His Leu Thr Ala Val Ser Ser Pro Ala Pro Gly Thr Pro Ala Phe Trp 
        35                  40                  45              


Val Ser Gly Trp Leu Gly Pro Gln Gln Tyr Leu Ser Tyr Asn Ser Leu 
    50                  55                  60                  


Arg Gly Glu Ala Glu Pro Cys Gly Ala Trp Val Trp Glu Asn Gln Val 
65                  70                  75                  80  


Ser Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Arg Ile Lys Glu Lys 
                85                  90                  95      


Leu Phe Leu Glu Ala Phe Lys Ala Leu Gly Gly Lys Gly Pro Tyr Thr 
            100                 105                 110         


Leu Gln Gly Leu Leu Gly Cys Glu Leu Gly Pro Asp Asn Thr Ser Val 
        115                 120                 125             


Pro Thr Ala Lys Phe Ala Leu Asn Gly Glu Glu Phe Met Asn Phe Asp 
    130                 135                 140                 


Leu Lys Gln Gly Thr Trp Gly Gly Asp Trp Pro Glu Ala Leu Ala Ile 
145                 150                 155                 160 


Ser Gln Arg Trp Gln Gln Gln Asp Lys Ala Ala Asn Lys Glu Leu Thr 
                165                 170                 175     


Phe Leu Leu Phe Ser Cys Pro His Arg Leu Arg Glu His Leu Glu Arg 
            180                 185                 190         


Gly Arg Gly Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg Leu Lys 
        195                 200                 205             


Ala Arg Pro Ser Ser Pro Gly Phe Ser Val Leu Thr Cys Ser Ala Phe 
    210                 215                 220                 


Ser Phe Tyr Pro Pro Glu Leu Gln Leu Arg Phe Leu Arg Asn Gly Leu 
225                 230                 235                 240 


Ala Ala Gly Thr Gly Gln Gly Asp Phe Gly Pro Asn Ser Asp Gly Ser 
                245                 250                 255     


Phe His Ala Ser Ser Ser Leu Thr Val Lys Ser Gly Asp Glu His His 
            260                 265                 270         


Tyr Cys Cys Ile Val Gln His Ala Gly Leu Ala Gln Pro Leu Arg Val 
        275                 280                 285             


Glu Leu Glu Ser Pro Ala Lys Ser Ser Val Leu Val Val Gly Ile Val 
    290                 295                 300                 


Ile Gly Val Leu Leu Leu Thr Ala Ala Ala Val Gly Gly Ala Leu Leu 
305                 310                 315                 320 


Trp Arg Arg Met Arg Ser Gly Leu Pro Ala Pro Trp Ile Ser Leu Arg 
                325                 330                 335     


Gly Asp Asp Thr Gly Val Leu Leu Pro Thr Pro Gly Glu Ala Gln Asp 
            340                 345                 350         


Ala Asp Leu Lys Asp Val Asn Val Ile Pro Ala Thr Ala 
        355                 360                 365 


<210>  2966
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  2966

Met Glu Leu Asp Arg Ala Val Gly Val Leu Gly Ala Ala Thr Leu Leu 
1               5                   10                  15      


Leu Ser Phe Leu Gly Met Ala Trp Ala Leu Gln Ala Ala Asp Thr Cys 
            20                  25                  30          


Pro Glu Val Lys Met Val Gly Leu Glu Gly Ser Asp Lys Leu Thr Ile 
        35                  40                  45              


Leu Arg Gly Cys Pro Gly Leu Pro Gly Ala Pro Gly Pro Lys Gly Glu 
    50                  55                  60                  


Ala Gly Thr Asn Gly Lys Arg Gly Glu Arg Gly Pro Pro Gly Pro Pro 
65                  70                  75                  80  


Gly Lys Ala Gly Pro Pro Gly Pro Asn Gly Ala Pro Gly Glu Pro Gln 
                85                  90                  95      


Pro Cys Leu Thr Gly Pro Arg Thr Cys Lys Asp Leu Leu Asp Arg Gly 
            100                 105                 110         


His Phe Leu Ser Gly Trp His Thr Ile Tyr Leu Pro Asp Cys Arg Pro 
        115                 120                 125             


Leu Thr Val Leu Cys Asp Met Asp Thr Asp Gly Gly Gly Trp Thr Val 
    130                 135                 140                 


Phe Gln Arg Arg Val Asp Gly Ser Val Asp Phe Tyr Arg Asp Trp Ala 
145                 150                 155                 160 


Thr Tyr Lys Gln Gly Phe Gly Ser Arg Leu Gly Glu Phe Trp Leu Gly 
                165                 170                 175     


Asn Asp Asn Ile His Ala Leu Thr Ala Gln Gly Thr Ser Glu Leu Arg 
            180                 185                 190         


Val Asp Leu Val Asp Phe Glu Asp Asn Tyr Gln Phe Ala Lys Tyr Arg 
        195                 200                 205             


Ser Phe Lys Val Ala Asp Glu Ala Glu Lys Tyr Asn Leu Val Leu Gly 
    210                 215                 220                 


Ala Phe Val Glu Gly Ser Ala Gly Asp Ser Leu Thr Phe His Asn Asn 
225                 230                 235                 240 


Gln Ser Phe Ser Thr Lys Asp Gln Asp Asn Asp Leu Asn Thr Gly Asn 
                245                 250                 255     


Cys Ala Val Met Phe Gln Gly Ala Trp Trp Tyr Lys Asn Cys His Val 
            260                 265                 270         


Ser Asn Leu Asn Gly Arg Tyr Leu Arg Gly Thr His Gly Ser Phe Ala 
        275                 280                 285             


Asn Gly Ile Asn Trp Lys Ser Gly Lys Gly Tyr Asn Tyr Ser Tyr Lys 
    290                 295                 300                 


Val Ser Glu Met Lys Val Arg Pro Ala 
305                 310             


<210>  2967
<211>  993
<212>  PRT
<213>  Homo sapiens

<400>  2967

Met Pro Ala Leu Ala Arg Asp Gly Gly Gln Leu Pro Leu Leu Val Val 
1               5                   10                  15      


Phe Ser Ala Met Ile Phe Gly Thr Ile Thr Asn Gln Asp Leu Pro Val 
            20                  25                  30          


Ile Lys Cys Val Leu Ile Asn His Lys Asn Asn Asp Ser Ser Val Gly 
        35                  40                  45              


Lys Ser Ser Ser Tyr Pro Met Val Ser Glu Ser Pro Glu Asp Leu Gly 
    50                  55                  60                  


Cys Ala Leu Arg Pro Gln Ser Ser Gly Thr Val Tyr Glu Ala Ala Ala 
65                  70                  75                  80  


Val Glu Val Asp Val Ser Ala Ser Ile Thr Leu Gln Val Leu Val Asp 
                85                  90                  95      


Ala Pro Gly Asn Ile Ser Cys Leu Trp Val Phe Lys His Ser Ser Leu 
            100                 105                 110         


Asn Cys Gln Pro His Phe Asp Leu Gln Asn Arg Gly Val Val Ser Met 
        115                 120                 125             


Val Ile Leu Lys Met Thr Glu Thr Gln Ala Gly Glu Tyr Leu Leu Phe 
    130                 135                 140                 


Ile Gln Ser Glu Ala Thr Asn Tyr Thr Ile Leu Phe Thr Val Ser Ile 
145                 150                 155                 160 


Arg Asn Thr Leu Leu Tyr Thr Leu Arg Arg Pro Tyr Phe Arg Lys Met 
                165                 170                 175     


Glu Asn Gln Asp Ala Leu Val Cys Ile Ser Glu Ser Val Pro Glu Pro 
            180                 185                 190         


Ile Val Glu Trp Val Leu Cys Asp Ser Gln Gly Glu Ser Cys Lys Glu 
        195                 200                 205             


Glu Ser Pro Ala Val Val Lys Lys Glu Glu Lys Val Leu His Glu Leu 
    210                 215                 220                 


Phe Gly Thr Asp Ile Arg Cys Cys Ala Arg Asn Glu Leu Gly Arg Glu 
225                 230                 235                 240 


Cys Thr Arg Leu Phe Thr Ile Asp Leu Asn Gln Thr Pro Gln Thr Thr 
                245                 250                 255     


Leu Pro Gln Leu Phe Leu Lys Val Gly Glu Pro Leu Trp Ile Arg Cys 
            260                 265                 270         


Lys Ala Val His Val Asn His Gly Phe Gly Leu Thr Trp Glu Leu Glu 
        275                 280                 285             


Asn Lys Ala Leu Glu Glu Gly Asn Tyr Phe Glu Met Ser Thr Tyr Ser 
    290                 295                 300                 


Thr Asn Arg Thr Met Ile Arg Ile Leu Phe Ala Phe Val Ser Ser Val 
305                 310                 315                 320 


Ala Arg Asn Asp Thr Gly Tyr Tyr Thr Cys Ser Ser Ser Lys His Pro 
                325                 330                 335     


Ser Gln Ser Ala Leu Val Thr Ile Val Glu Lys Gly Phe Ile Asn Ala 
            340                 345                 350         


Thr Asn Ser Ser Glu Asp Tyr Glu Ile Asp Gln Tyr Glu Glu Phe Cys 
        355                 360                 365             


Phe Ser Val Arg Phe Lys Ala Tyr Pro Gln Ile Arg Cys Thr Trp Thr 
    370                 375                 380                 


Phe Ser Arg Lys Ser Phe Pro Cys Glu Gln Lys Gly Leu Asp Asn Gly 
385                 390                 395                 400 


Tyr Ser Ile Ser Lys Phe Cys Asn His Lys His Gln Pro Gly Glu Tyr 
                405                 410                 415     


Ile Phe His Ala Glu Asn Asp Asp Ala Gln Phe Thr Lys Met Phe Thr 
            420                 425                 430         


Leu Asn Ile Arg Arg Lys Pro Gln Val Leu Ala Glu Ala Ser Ala Ser 
        435                 440                 445             


Gln Ala Ser Cys Phe Ser Asp Gly Tyr Pro Leu Pro Ser Trp Thr Trp 
    450                 455                 460                 


Lys Lys Cys Ser Asp Lys Ser Pro Asn Cys Thr Glu Glu Ile Thr Glu 
465                 470                 475                 480 


Gly Val Trp Asn Arg Lys Ala Asn Arg Lys Val Phe Gly Gln Trp Val 
                485                 490                 495     


Ser Ser Ser Thr Leu Asn Met Ser Glu Ala Ile Lys Gly Phe Leu Val 
            500                 505                 510         


Lys Cys Cys Ala Tyr Asn Ser Leu Gly Thr Ser Cys Glu Thr Ile Leu 
        515                 520                 525             


Leu Asn Ser Pro Gly Pro Phe Pro Phe Ile Gln Asp Asn Ile Ser Phe 
    530                 535                 540                 


Tyr Ala Thr Ile Gly Val Cys Leu Leu Phe Ile Val Val Leu Thr Leu 
545                 550                 555                 560 


Leu Ile Cys His Lys Tyr Lys Lys Gln Phe Arg Tyr Glu Ser Gln Leu 
                565                 570                 575     


Gln Met Val Gln Val Thr Gly Ser Ser Asp Asn Glu Tyr Phe Tyr Val 
            580                 585                 590         


Asp Phe Arg Glu Tyr Glu Tyr Asp Leu Lys Trp Glu Phe Pro Arg Glu 
        595                 600                 605             


Asn Leu Glu Phe Gly Lys Val Leu Gly Ser Gly Ala Phe Gly Lys Val 
    610                 615                 620                 


Met Asn Ala Thr Ala Tyr Gly Ile Ser Lys Thr Gly Val Ser Ile Gln 
625                 630                 635                 640 


Val Ala Val Lys Met Leu Lys Glu Lys Ala Asp Ser Ser Glu Arg Glu 
                645                 650                 655     


Ala Leu Met Ser Glu Leu Lys Met Met Thr Gln Leu Gly Ser His Glu 
            660                 665                 670         


Asn Ile Val Asn Leu Leu Gly Ala Cys Thr Leu Ser Gly Pro Ile Tyr 
        675                 680                 685             


Leu Ile Phe Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Tyr Leu Arg 
    690                 695                 700                 


Ser Lys Arg Glu Lys Phe His Arg Thr Trp Thr Glu Ile Phe Lys Glu 
705                 710                 715                 720 


His Asn Phe Ser Phe Tyr Pro Thr Phe Gln Ser His Pro Asn Ser Ser 
                725                 730                 735     


Met Pro Gly Ser Arg Glu Val Gln Ile His Pro Asp Ser Asp Gln Ile 
            740                 745                 750         


Ser Gly Leu His Gly Asn Ser Phe His Ser Glu Asp Glu Ile Glu Tyr 
        755                 760                 765             


Glu Asn Gln Lys Arg Leu Glu Glu Glu Glu Asp Leu Asn Val Leu Thr 
    770                 775                 780                 


Phe Glu Asp Leu Leu Cys Phe Ala Tyr Gln Val Ala Lys Gly Met Glu 
785                 790                 795                 800 


Phe Leu Glu Phe Lys Ser Cys Val His Arg Asp Leu Ala Ala Arg Asn 
                805                 810                 815     


Val Leu Val Thr His Gly Lys Val Val Lys Ile Cys Asp Phe Gly Leu 
            820                 825                 830         


Ala Arg Asp Ile Met Ser Asp Ser Asn Tyr Val Val Arg Gly Asn Ala 
        835                 840                 845             


Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ser Leu Phe Glu Gly Ile 
    850                 855                 860                 


Tyr Thr Ile Lys Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu 
865                 870                 875                 880 


Ile Phe Ser Leu Gly Val Asn Pro Tyr Pro Gly Ile Pro Val Asp Ala 
                885                 890                 895     


Asn Phe Tyr Lys Leu Ile Gln Asn Gly Phe Lys Met Asp Gln Pro Phe 
            900                 905                 910         


Tyr Ala Thr Glu Glu Ile Tyr Ile Ile Met Gln Ser Cys Trp Ala Phe 
        915                 920                 925             


Asp Ser Arg Lys Arg Pro Ser Phe Pro Asn Leu Thr Ser Phe Leu Gly 
    930                 935                 940                 


Cys Gln Leu Ala Asp Ala Glu Glu Ala Met Tyr Gln Asn Val Asp Gly 
945                 950                 955                 960 


Arg Val Ser Glu Cys Pro His Thr Tyr Gln Asn Arg Arg Pro Phe Ser 
                965                 970                 975     


Arg Glu Met Asp Leu Gly Leu Leu Ser Pro Gln Ala Gln Val Glu Asp 
            980                 985                 990         


Ser 
    


<210>  2968
<211>  586
<212>  PRT
<213>  Homo sapiens

<400>  2968

Met Ala Arg Gly Tyr Gly Ala Thr Val Ser Leu Val Leu Leu Gly Leu 
1               5                   10                  15      


Gly Leu Ala Leu Ala Val Ile Val Leu Ala Val Val Leu Ser Arg His 
            20                  25                  30          


Gln Ala Pro Cys Gly Pro Gln Ala Phe Ala His Ala Ala Val Ala Ala 
        35                  40                  45              


Asp Ser Lys Val Cys Ser Asp Ile Gly Arg Ala Ile Leu Gln Gln Gln 
    50                  55                  60                  


Gly Ser Pro Val Asp Ala Thr Ile Ala Ala Leu Val Cys Thr Ser Val 
65                  70                  75                  80  


Val Asn Pro Gln Ser Met Gly Leu Gly Gly Gly Val Ile Phe Thr Ile 
                85                  90                  95      


Tyr Asn Val Thr Thr Gly Lys Val Glu Val Ile Asn Ala Arg Glu Thr 
            100                 105                 110         


Val Pro Ala Ser His Ala Pro Ser Leu Leu Asp Gln Cys Ala Gln Ala 
        115                 120                 125             


Leu Pro Leu Gly Thr Gly Ala Gln Trp Ile Gly Val Pro Gly Glu Leu 
    130                 135                 140                 


Arg Gly Tyr Ala Glu Ala His Arg Arg His Gly Arg Leu Pro Trp Ala 
145                 150                 155                 160 


Gln Leu Phe Gln Pro Thr Ile Ala Leu Leu Arg Gly Gly His Val Val 
                165                 170                 175     


Ala Pro Val Leu Ser Arg Phe Leu His Asn Ser Ile Leu Arg Pro Ser 
            180                 185                 190         


Leu Gln Ala Ser Thr Leu Arg Gln Leu Phe Phe Asn Gly Thr Glu Pro 
        195                 200                 205             


Leu Arg Pro Gln Asp Pro Leu Pro Trp Pro Ala Leu Ala Thr Thr Leu 
    210                 215                 220                 


Glu Thr Val Ala Thr Glu Gly Val Glu Val Phe Tyr Thr Gly Arg Leu 
225                 230                 235                 240 


Gly Gln Met Leu Val Glu Asp Ile Ala Lys Glu Gly Ser Gln Leu Thr 
                245                 250                 255     


Leu Gln Asp Leu Ala Lys Phe Gln Pro Glu Val Val Asp Ala Leu Glu 
            260                 265                 270         


Val Pro Leu Gly Asp Tyr Thr Leu Tyr Ser Pro Pro Pro Pro Ala Gly 
        275                 280                 285             


Gly Ala Ile Leu Ser Phe Ile Leu Asn Val Leu Arg Gly Phe Asn Phe 
    290                 295                 300                 


Ser Thr Glu Ser Met Ala Arg Pro Glu Gly Arg Val Asn Val Tyr His 
305                 310                 315                 320 


His Leu Val Glu Thr Leu Lys Phe Ala Lys Gly Gln Arg Trp Arg Leu 
                325                 330                 335     


Gly Asp Pro Arg Ser His Pro Lys Leu Gln Asn Ala Ser Arg Asp Leu 
            340                 345                 350         


Leu Gly Glu Thr Leu Ala Gln Leu Ile Arg Gln Gln Ile Asp Gly Arg 
        355                 360                 365             


Gly Asp His Gln Leu Ser His Tyr Ser Leu Ala Glu Ala Trp Gly His 
    370                 375                 380                 


Gly Thr Gly Thr Ser His Val Ser Val Leu Gly Glu Asp Gly Ser Ala 
385                 390                 395                 400 


Val Ala Ala Thr Ser Thr Ile Asn Thr Pro Phe Gly Ala Met Val Tyr 
                405                 410                 415     


Ser Pro Arg Thr Gly Ile Ile Leu Asn Asn Glu Leu Leu Asp Leu Cys 
            420                 425                 430         


Glu Arg Cys Pro Arg Gly Ser Gly Thr Thr Pro Ser Pro Val Ser Gly 
        435                 440                 445             


Asp Arg Val Gly Gly Ala Pro Gly Arg Cys Trp Pro Pro Val Pro Gly 
    450                 455                 460                 


Glu Arg Ser Pro Ser Ser Met Val Pro Ser Ile Leu Ile Asn Lys Ala 
465                 470                 475                 480 


Gln Gly Ser Lys Leu Val Ile Gly Gly Ala Gly Gly Glu Leu Ile Ile 
                485                 490                 495     


Ser Ala Val Ala Gln Ala Ile Met Ser Lys Leu Trp Leu Gly Phe Asp 
            500                 505                 510         


Leu Arg Ala Ala Ile Ala Ala Pro Ile Leu His Val Asn Ser Lys Gly 
        515                 520                 525             


Cys Val Glu Tyr Glu Pro Asn Phe Ser Gln Glu Val Gln Arg Gly Leu 
    530                 535                 540                 


Gln Asp Arg Gly Gln Asn Gln Thr Gln Arg Pro Phe Phe Leu Asn Val 
545                 550                 555                 560 


Val Gln Ala Val Ser Gln Glu Gly Ala Cys Val Tyr Ala Val Ser Asp 
                565                 570                 575     


Leu Arg Lys Ser Gly Glu Ala Ala Gly Tyr 
            580                 585     


<210>  2969
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  2969

Met Trp Asn Ala Thr Pro Ser Glu Glu Pro Gly Phe Asn Leu Thr Leu 
1               5                   10                  15      


Ala Asp Leu Asp Trp Asp Ala Ser Pro Gly Asn Asp Ser Leu Gly Asp 
            20                  25                  30          


Glu Leu Leu Gln Leu Phe Pro Ala Pro Leu Leu Ala Gly Val Thr Ala 
        35                  40                  45              


Thr Cys Val Ala Leu Phe Val Val Gly Ile Ala Gly Asn Leu Leu Thr 
    50                  55                  60                  


Met Leu Val Val Ser Arg Phe Arg Glu Leu Arg Thr Thr Thr Asn Leu 
65                  70                  75                  80  


Tyr Leu Ser Ser Met Ala Phe Ser Asp Leu Leu Ile Phe Leu Cys Met 
                85                  90                  95      


Pro Leu Asp Leu Val Arg Leu Trp Gln Tyr Arg Pro Trp Asn Phe Gly 
            100                 105                 110         


Asp Leu Leu Cys Lys Leu Phe Gln Phe Val Ser Glu Ser Cys Thr Tyr 
        115                 120                 125             


Ala Thr Val Leu Thr Ile Thr Ala Leu Ser Val Glu Arg Tyr Phe Ala 
    130                 135                 140                 


Ile Cys Phe Pro Leu Arg Ala Lys Val Val Val Thr Lys Gly Arg Val 
145                 150                 155                 160 


Lys Leu Val Ile Phe Val Ile Trp Ala Val Ala Phe Cys Ser Ala Gly 
                165                 170                 175     


Pro Ile Phe Val Leu Val Gly Val Glu His Glu Asn Gly Thr Asp Pro 
            180                 185                 190         


Trp Asp Thr Asn Glu Cys Arg Pro Thr Glu Phe Ala Val Arg Ser Gly 
        195                 200                 205             


Leu Leu Thr Val Met Val Trp Val Ser Ser Ile Phe Phe Phe Leu Pro 
    210                 215                 220                 


Val Phe Cys Leu Thr Val Leu Tyr Ser Leu Ile Gly Arg Lys Leu Trp 
225                 230                 235                 240 


Arg Arg Arg Arg Gly Asp Ala Val Val Gly Ala Ser Leu Arg Asp Gln 
                245                 250                 255     


Asn His Lys Gln Thr Val Lys Met Leu Gly Gly Ser Gln Arg Ala Leu 
            260                 265                 270         


Arg Leu Ser Leu Ala Gly Pro Ile Leu Ser Leu Cys Leu Leu Pro Ser 
        275                 280                 285             


Leu 
    


<210>  2970
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  2970

Met Ser Glu Ser Leu Val Val Cys Asp Val Ala Glu Asp Leu Val Glu 
1               5                   10                  15      


Lys Leu Arg Lys Phe Arg Phe Arg Lys Glu Thr Asn Asn Ala Ala Ile 
            20                  25                  30          


Ile Met Lys Ile Asp Lys Asp Lys Arg Leu Val Val Leu Asp Glu Glu 
        35                  40                  45              


Leu Glu Gly Ile Ser Pro Asp Glu Leu Lys Asp Glu Leu Pro Glu Arg 
    50                  55                  60                  


Gln Pro Arg Phe Ile Val Tyr Ser Tyr Lys Tyr Gln His Asp Asp Gly 
65                  70                  75                  80  


Arg Val Ser Tyr Pro Leu Cys Phe Ile Phe Ser Ser Pro Val Gly Cys 
                85                  90                  95      


Lys Pro Glu Gln Gln Met Met Tyr Ala Gly Ser Lys Asn Lys Leu Val 
            100                 105                 110         


Gln Thr Ala Glu Leu Thr Lys Val Phe Glu Ile Arg Asn Thr Glu Asp 
        115                 120                 125             


Leu Thr Glu Glu Trp Leu Arg Glu Lys Leu Gly Phe Phe His 
    130                 135                 140         


<210>  2971
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  2971

Met Gly Ala Pro Leu Leu Ser Pro Gly Trp Gly Ala Gly Ala Ala Gly 
1               5                   10                  15      


Arg Arg Trp Trp Met Leu Leu Ala Pro Leu Leu Pro Ala Leu Leu Leu 
            20                  25                  30          


Val Arg Pro Ala Gly Ala Leu Val Glu Gly Leu Tyr Cys Gly Thr Arg 
        35                  40                  45              


Asp Cys Tyr Glu Val Leu Gly Val Ser Arg Ser Ala Gly Lys Ala Glu 
    50                  55                  60                  


Ile Ala Arg Ala Tyr Arg Gln Leu Ala Arg Arg Tyr His Pro Asp Arg 
65                  70                  75                  80  


Tyr Arg Pro Gln Pro Gly Asp Glu Gly Pro Gly Arg Thr Pro Gln Ser 
                85                  90                  95      


Ala Glu Glu Ala Phe Leu Leu Val Ala Thr Ala Tyr Glu Thr Leu Lys 
            100                 105                 110         


Val Ser Gln Ala Ala Ala Glu Leu Gln Gln Tyr Cys Met Gln Asn Ala 
        115                 120                 125             


Cys Lys Asp Ala Leu Leu Val Gly Val Pro Ala Gly Ser Asn Pro Phe 
    130                 135                 140                 


Arg Glu Pro Arg Ser Cys Ala Leu Leu 
145                 150             


<210>  2972
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  2972

Met Val Lys Lys Leu Val Met Ala Gln Lys Arg Gly Glu Thr Arg Ala 
1               5                   10                  15      


Leu Cys Leu Gly Val Thr Met Val Val Cys Ala Val Ile Thr Tyr Tyr 
            20                  25                  30          


Ile Leu Val Thr Thr Val Leu Pro Leu Tyr Gln Lys Ser Val Trp Thr 
        35                  40                  45              


Gln Glu Ser Lys Cys His Leu Ile Glu Thr Asn Ile Arg Asp Gln Glu 
    50                  55                  60                  


Glu Leu Lys Gly Lys Lys Val Pro Gln Tyr Pro Cys Leu Trp Val Asn 
65                  70                  75                  80  


Val Ser Ala Ala Gly Arg Trp Ala Val Leu Tyr His Thr Glu Asp Thr 
                85                  90                  95      


Arg Asp Gln Asn Gln Gln Cys Ser Tyr Ile Pro Gly Ser Val Asp Asn 
            100                 105                 110         


Tyr Gln Thr Ala Arg Ala Asp Val Glu Lys Val Arg Ala Lys Phe Gln 
        115                 120                 125             


Glu Gln Gln Val Phe Tyr Cys Phe Ser Ala Pro Arg Gly Asn Glu Thr 
    130                 135                 140                 


Ser Val Leu Phe Gln Arg Leu Tyr Gly Pro Gln Ala Leu Leu Phe Ser 
145                 150                 155                 160 


Leu Phe Trp Pro Thr Phe Leu Leu Thr Gly Gly Leu Leu Ile Ile Ala 
                165                 170                 175     


Met Val Lys Ser Asn Gln Tyr Leu Ser Ile Leu Ala Ala Gln Lys 
            180                 185                 190     


<210>  2973
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  2973

Met Asp Ser Gly Thr Glu Glu Tyr Glu Leu Asn Gly Gly Leu Pro Pro 
1               5                   10                  15      


Gly Thr Pro Gly Ser Pro Asp Ala Ser Pro Ala Arg Trp Gly Trp Arg 
            20                  25                  30          


His Gly Pro Ile Asn Val Asn His Tyr Ala Ser Lys Lys Ser Ala Ala 
        35                  40                  45              


Glu Ser Met Leu Asp Ile Ala Leu Leu Met Ala Asn Ala Ser Gln Leu 
    50                  55                  60                  


Lys Ala Val Val Glu Gln Gly Pro Ser Phe Ala Phe Tyr Val Pro Leu 
65                  70                  75                  80  


Val Val Leu Ile Ser Ile Ser Leu Val Leu Gln Ile Gly Val Gly Val 
                85                  90                  95      


Leu Leu Ile Phe Leu Val Lys Tyr Asp Leu Asn Asn Pro Ala Lys His 
            100                 105                 110         


Ala Lys Leu Asp Phe Leu Asn Asn Leu Ala Thr Gly Leu Val Phe Ile 
        115                 120                 125             


Ile Val Val Val Asn Ile Phe Ile Thr Ala Phe Gly Val Gln Lys Pro 
    130                 135                 140                 


Leu Met Asp Met Ala Pro Gln Gln 
145                 150         


<210>  2974
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  2974

Met Glu Trp Asp Asn Gly Thr Gly Gln Ala Leu Gly Leu Pro Pro Thr 
1               5                   10                  15      


Thr Cys Val Tyr Arg Glu Asn Phe Lys Gln Leu Leu Leu Pro Pro Val 
            20                  25                  30          


Tyr Ser Ala Val Leu Ala Ala Gly Leu Pro Leu Asn Ile Cys Val Ile 
        35                  40                  45              


Thr Gln Ile Cys Thr Ser Arg Arg Ala Leu Thr Arg Thr Ala Val Tyr 
    50                  55                  60                  


Thr Leu Asn Leu Ala Leu Ala Asp Leu Leu Tyr Ala Cys Ser Leu Pro 
65                  70                  75                  80  


Leu Leu Ile Tyr Asn Tyr Ala Gln Gly Asp His Trp Pro Phe Gly Asp 
                85                  90                  95      


Phe Ala Cys Arg Leu Val Arg Phe Leu Phe Tyr Ala Asn Leu His Gly 
            100                 105                 110         


Ser Ile Leu Phe Leu Thr Cys Ile Ser Phe Gln Arg Tyr Leu Gly Ile 
        115                 120                 125             


Cys His Pro Leu Ala Pro Trp His Lys Arg Gly Gly Arg Arg Ala Ala 
    130                 135                 140                 


Trp Leu Val Cys Val Ala Val Trp Leu Ala Val Thr Thr Gln Cys Leu 
145                 150                 155                 160 


Pro Thr Ala Ile Phe Ala Ala Thr Gly Ile Gln Arg Asn Arg Thr Val 
                165                 170                 175     


Cys Tyr Asp Leu Ser Pro Pro Ala Leu Ala Thr His Tyr Met Pro Tyr 
            180                 185                 190         


Gly Met Ala Leu Thr Val Ile Gly Phe Leu Leu Pro Phe Ala Ala Leu 
        195                 200                 205             


Leu Ala Cys Tyr Cys Leu Leu Ala Cys Arg Leu Cys Arg Gln Asp Gly 
    210                 215                 220                 


Pro Ala Glu Pro Val Ala Gln Glu Arg Arg Gly Lys Ala Ala Arg Met 
225                 230                 235                 240 


Ala Val Val Val Ala Ala Ala Phe Ala Ile Ser Phe Leu Pro Phe His 
                245                 250                 255     


Ile Thr Lys Thr Ala Tyr Leu Ala Val Arg Ser Thr Pro Gly Val Pro 
            260                 265                 270         


Cys Thr Val Leu Glu Ala Phe Ala Ala Ala Tyr Lys Gly Thr Arg Pro 
        275                 280                 285             


Phe Ala Ser Ala Asn Ser Val Leu Asp Pro Ile Leu Phe Tyr Phe Thr 
    290                 295                 300                 


Gln Lys Lys Phe Arg Arg Arg Pro His Glu Leu Leu Gln Lys Leu Thr 
305                 310                 315                 320 


Ala Lys Trp Gln Arg Gln Gly Arg 
                325             


<210>  2975
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  2975

Met Val Phe Val Arg Arg Pro Trp Pro Ala Leu Thr Thr Val Leu Leu 
1               5                   10                  15      


Ala Leu Leu Val Cys Leu Gly Ala Leu Val Asp Ala Tyr Pro Ile Lys 
            20                  25                  30          


Pro Glu Ala Pro Gly Glu Asp Ala Ser Pro Glu Glu Leu Asn Arg Tyr 
        35                  40                  45              


Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Val Thr Arg Gln Arg Tyr 
    50                  55                  60                  


Gly Lys Arg Asp Gly Pro Asp Thr Leu Leu Ser Lys Thr Phe Phe Pro 
65                  70                  75                  80  


Asp Gly Glu Asp Arg Pro Val Arg Ser Arg Ser Glu Gly Pro Asp Leu 
                85                  90                  95      


Trp 
    


<210>  2976
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  2976

Met Gly Lys Pro Ala Arg Lys Gly Cys Glu Trp Lys Arg Phe Leu Lys 
1               5                   10                  15      


Asn Asn Trp Val Leu Leu Ser Thr Val Ala Ala Val Val Leu Gly Ile 
            20                  25                  30          


Thr Thr Gly Val Leu Val Arg Glu His Ser Asn Leu Ser Thr Leu Glu 
        35                  40                  45              


Lys Phe Tyr Phe Ala Phe Pro Gly Glu Ile Leu Met Arg Met Leu Lys 
    50                  55                  60                  


Leu Ile Ile Leu Pro Leu Ile Ile Ser Ser Met Ile Thr Gly Val Ala 
65                  70                  75                  80  


Ala Leu Asp Ser Asn Val Ser Gly Lys Ile Gly Leu Arg Ala Val Val 
                85                  90                  95      


Tyr Tyr Phe Cys Thr Thr Leu Ile Ala Val Ile Leu Gly Ile Val Leu 
            100                 105                 110         


Val Val Ser Ile Lys Pro Gly Val Thr Gln Lys Val Gly Glu Ile Ala 
        115                 120                 125             


Arg Thr Gly Ser Thr Pro Glu Val Ser Thr Val Asp Ala Met Leu Asp 
    130                 135                 140                 


Leu Ile Arg Asn Met Phe Pro Glu Asn Leu Val Gln Ala Cys Phe Gln 
145                 150                 155                 160 


Gln Tyr Lys Thr Lys Arg Glu Glu Val Lys Pro Pro Ser Asp Pro Glu 
                165                 170                 175     


Met Asn Met Thr Glu Glu Ser Phe Thr Ala Val Met Thr Thr Ala Ile 
            180                 185                 190         


Ser Lys Asn Lys Thr Lys Glu Tyr Lys Ile Val Gly Met Tyr Ser Asp 
        195                 200                 205             


Gly Ile Asn Val Leu Gly Leu Ile Val Phe Cys Leu Val Phe Gly Leu 
    210                 215                 220                 


Val Ile Gly Lys Met Gly Glu Lys Gly Gln Ile Leu Val Asp Phe Phe 
225                 230                 235                 240 


Asn Ala Leu Ser Asp Ala Thr Met Lys Ile Val Gln Ile Ile Met Cys 
                245                 250                 255     


Tyr Met Pro Leu Gly Ile Leu Phe Leu Ile Ala Gly Lys Ile Ile Glu 
            260                 265                 270         


Val Glu Asp Trp Glu Ile Phe Arg Lys Leu Gly Leu Tyr Met Ala Thr 
        275                 280                 285             


Val Leu Thr Gly Leu Ala Ile His Ser Ile Val Ile Leu Pro Leu Ile 
    290                 295                 300                 


Tyr Phe Ile Val Val Arg Lys Asn Pro Phe Arg Phe Ala Met Gly Met 
305                 310                 315                 320 


Ala Gln Ala Leu Leu Thr Ala Leu Met Ile Ser Ser Ser Ser Ala Thr 
                325                 330                 335     


Leu Pro Val Thr Phe Arg Cys Ala Glu Glu Asn Asn Gln Val Asp Lys 
            340                 345                 350         


Arg Ile Thr Arg Phe Val Leu Pro Val Gly Ala Thr Ile Asn Met Asp 
        355                 360                 365             


Gly Thr Ala Leu Tyr Glu Ala Val Ala Ala Val Phe Ile Ala Gln Leu 
    370                 375                 380                 


Asn Asp Leu Asp Leu Gly Ile Gly Gln Ile Ile Thr Ile Ser Ile Thr 
385                 390                 395                 400 


Ala Thr Ser Ala Ser Ile Gly Ala Ala Gly Val Pro Gln Ala Gly Leu 
                405                 410                 415     


Val Thr Met Val Ile Val Leu Ser Ala Val Gly Leu Pro Ala Glu Asp 
            420                 425                 430         


Val Thr Leu Ile Ile Ala Val Asp Trp Leu Leu Asp Arg Phe Arg Thr 
        435                 440                 445             


Met Val Asn Val Leu Gly Asp Ala Phe Gly Thr Gly Ile Val Glu Lys 
    450                 455                 460                 


Leu Ser Lys Lys Glu Leu Glu Gln Met Asp Val Ser Ser Glu Val Asn 
465                 470                 475                 480 


Ile Val Asn Pro Phe Ala Leu Glu Ser Thr Ile Leu Asp Asn Glu Asp 
                485                 490                 495     


Ser Asp Thr Lys Lys Ser Tyr Val Asn Gly Gly Phe Ala Val Asp Lys 
            500                 505                 510         


Ser Asp Thr Ile Ser Phe Thr Gln Thr Ser Gln Phe 
        515                 520                 


<210>  2977
<211>  574
<212>  PRT
<213>  Homo sapiens

<400>  2977

Met Ala Ser Thr Glu Gly Ala Asn Asn Met Pro Lys Gln Val Glu Val 
1               5                   10                  15      


Arg Met His Asp Ser His Leu Gly Ser Glu Glu Pro Lys His Arg His 
            20                  25                  30          


Leu Gly Leu Arg Leu Cys Asp Lys Leu Gly Lys Asn Leu Leu Leu Thr 
        35                  40                  45              


Leu Thr Val Phe Gly Val Ile Leu Gly Ala Val Cys Gly Gly Leu Leu 
    50                  55                  60                  


Arg Leu Ala Ser Pro Ile His Pro Asp Val Val Met Leu Ile Ala Phe 
65                  70                  75                  80  


Pro Gly Asp Ile Leu Met Arg Met Leu Lys Met Leu Ile Leu Pro Leu 
                85                  90                  95      


Ile Ile Ser Ser Leu Ile Thr Gly Leu Ser Gly Leu Asp Ala Lys Ala 
            100                 105                 110         


Ser Gly Arg Leu Gly Thr Arg Ala Met Val Tyr Tyr Met Ser Thr Thr 
        115                 120                 125             


Ile Ile Ala Ala Val Leu Gly Val Ile Leu Val Leu Ala Ile His Pro 
    130                 135                 140                 


Gly Asn Pro Lys Leu Lys Lys Gln Leu Gly Pro Gly Lys Lys Asn Asp 
145                 150                 155                 160 


Glu Val Ser Ser Leu Asp Ala Phe Leu Asp Leu Ile Arg Asn Leu Phe 
                165                 170                 175     


Pro Glu Asn Leu Val Gln Ala Cys Phe Gln Gln Ile Gln Thr Val Thr 
            180                 185                 190         


Lys Lys Val Leu Val Ala Pro Pro Pro Asp Glu Glu Ala Asn Ala Thr 
        195                 200                 205             


Ser Ala Val Val Ser Leu Leu Asn Glu Thr Val Thr Glu Val Pro Glu 
    210                 215                 220                 


Glu Thr Lys Met Val Ile Lys Lys Gly Leu Glu Phe Lys Asp Gly Met 
225                 230                 235                 240 


Asn Val Leu Gly Leu Ile Gly Phe Phe Ile Ala Phe Gly Ile Ala Met 
                245                 250                 255     


Gly Lys Met Gly Asp Gln Ala Lys Leu Met Val Asp Phe Phe Asn Ile 
            260                 265                 270         


Leu Asn Glu Ile Val Met Lys Leu Val Ile Met Ile Met Trp Tyr Ser 
        275                 280                 285             


Pro Leu Gly Ile Ala Cys Leu Ile Cys Gly Lys Ile Ile Ala Ile Lys 
    290                 295                 300                 


Asp Leu Glu Val Val Ala Arg Gln Leu Gly Met Tyr Met Val Thr Val 
305                 310                 315                 320 


Ile Ile Gly Leu Ile Ile His Gly Gly Ile Phe Leu Pro Leu Ile Tyr 
                325                 330                 335     


Phe Val Val Thr Arg Lys Asn Pro Phe Ser Phe Phe Ala Gly Ile Phe 
            340                 345                 350         


Gln Ala Trp Ile Thr Ala Leu Gly Thr Ala Ser Ser Ala Gly Thr Leu 
        355                 360                 365             


Pro Val Thr Phe Arg Cys Leu Glu Glu Asn Leu Gly Ile Asp Lys Arg 
    370                 375                 380                 


Val Thr Arg Phe Val Leu Pro Val Gly Ala Thr Ile Asn Met Asp Gly 
385                 390                 395                 400 


Thr Ala Leu Tyr Glu Ala Val Ala Ala Ile Phe Ile Ala Gln Met Asn 
                405                 410                 415     


Gly Val Val Leu Asp Gly Gly Gln Ile Val Thr Val Ser Leu Thr Ala 
            420                 425                 430         


Thr Leu Ala Ser Val Gly Ala Ala Ser Ile Pro Ser Ala Gly Leu Val 
        435                 440                 445             


Thr Met Leu Leu Ile Leu Thr Ala Val Gly Leu Pro Thr Glu Asp Ile 
    450                 455                 460                 


Ser Leu Leu Val Ala Val Asp Trp Leu Leu Asp Arg Met Arg Thr Ser 
465                 470                 475                 480 


Val Asn Val Val Gly Asp Ser Phe Gly Ala Gly Ile Val Tyr His Leu 
                485                 490                 495     


Ser Lys Ser Glu Leu Asp Thr Ile Asp Ser Gln His Arg Val His Glu 
            500                 505                 510         


Asp Ile Glu Met Thr Lys Thr Gln Ser Ile Tyr Asp Asp Met Lys Asn 
        515                 520                 525             


His Arg Glu Ser Asn Ser Asn Gln Cys Val Tyr Ala Ala His Asn Ser 
    530                 535                 540                 


Val Ile Val Asp Glu Cys Lys Val Thr Leu Ala Ala Asn Gly Lys Ser 
545                 550                 555                 560 


Ala Asp Cys Ser Val Glu Glu Glu Pro Trp Lys Arg Glu Lys 
                565                 570                 


<210>  2978
<211>  542
<212>  PRT
<213>  Homo sapiens

<400>  2978

Met Thr Lys Ser Asn Gly Glu Glu Pro Lys Met Gly Gly Arg Met Glu 
1               5                   10                  15      


Arg Phe Gln Gln Gly Val Arg Lys Arg Thr Leu Leu Ala Lys Lys Lys 
            20                  25                  30          


Val Gln Asn Ile Thr Lys Glu Asp Val Lys Ser Tyr Leu Phe Arg Asn 
        35                  40                  45              


Ala Phe Val Leu Leu Thr Val Thr Ala Val Ile Val Gly Thr Ile Leu 
    50                  55                  60                  


Gly Phe Thr Leu Arg Pro Tyr Arg Met Ser Tyr Arg Glu Val Lys Tyr 
65                  70                  75                  80  


Phe Ser Phe Pro Gly Glu Leu Leu Met Arg Met Leu Gln Met Leu Val 
                85                  90                  95      


Leu Pro Leu Ile Ile Ser Ser Leu Val Thr Gly Met Ala Ala Leu Asp 
            100                 105                 110         


Ser Lys Ala Ser Gly Lys Met Gly Met Arg Ala Val Val Tyr Tyr Met 
        115                 120                 125             


Thr Thr Thr Ile Ile Ala Val Val Ile Gly Ile Ile Ile Val Ile Ile 
    130                 135                 140                 


Ile His Pro Gly Lys Gly Thr Lys Glu Asn Met His Arg Glu Gly Lys 
145                 150                 155                 160 


Ile Val Arg Val Thr Ala Ala Asp Ala Phe Leu Asp Leu Ile Arg Asn 
                165                 170                 175     


Met Phe Pro Pro Asn Leu Val Glu Ala Cys Phe Lys Gln Phe Lys Thr 
            180                 185                 190         


Asn Tyr Glu Lys Arg Ser Phe Lys Val Pro Ile Gln Ala Asn Glu Thr 
        195                 200                 205             


Leu Val Gly Ala Val Ile Asn Asn Val Ser Glu Ala Met Glu Thr Leu 
    210                 215                 220                 


Thr Arg Ile Thr Glu Glu Leu Val Pro Val Pro Gly Ser Val Asn Gly 
225                 230                 235                 240 


Val Asn Ala Leu Gly Leu Val Val Phe Ser Met Cys Phe Gly Phe Val 
                245                 250                 255     


Ile Gly Asn Met Lys Glu Gln Gly Gln Ala Leu Arg Glu Phe Phe Asp 
            260                 265                 270         


Ser Leu Asn Glu Ala Ile Met Arg Leu Val Ala Val Ile Met Trp Tyr 
        275                 280                 285             


Ala Pro Val Gly Ile Leu Phe Leu Ile Ala Gly Lys Ile Val Glu Met 
    290                 295                 300                 


Glu Asp Met Gly Val Ile Gly Gly Gln Leu Ala Met Tyr Thr Val Thr 
305                 310                 315                 320 


Val Ile Val Gly Leu Leu Ile His Ala Val Ile Val Leu Pro Leu Leu 
                325                 330                 335     


Tyr Phe Leu Val Thr Arg Lys Asn Pro Trp Val Phe Ile Gly Gly Leu 
            340                 345                 350         


Leu Gln Ala Leu Ile Thr Ala Leu Gly Thr Ser Ser Ser Ser Ala Thr 
        355                 360                 365             


Leu Pro Ile Thr Phe Lys Cys Leu Glu Glu Asn Asn Gly Val Asp Lys 
    370                 375                 380                 


Arg Val Thr Arg Phe Val Leu Pro Val Gly Ala Thr Ile Asn Met Asp 
385                 390                 395                 400 


Gly Thr Ala Leu Tyr Glu Ala Leu Ala Ala Ile Phe Ile Ala Gln Val 
                405                 410                 415     


Asn Asn Phe Glu Leu Asn Phe Gly Gln Ile Ile Thr Ile Ser Ile Thr 
            420                 425                 430         


Ala Thr Ala Ala Ser Ile Gly Ala Ala Gly Ile Pro Gln Ala Gly Leu 
        435                 440                 445             


Val Thr Met Val Ile Val Leu Thr Ser Val Gly Leu Pro Thr Asp Asp 
    450                 455                 460                 


Ile Thr Leu Ile Ile Ala Val Asp Trp Phe Leu Asp Arg Leu Arg Thr 
465                 470                 475                 480 


Thr Thr Asn Val Leu Gly Asp Ser Leu Gly Ala Gly Ile Val Glu His 
                485                 490                 495     


Leu Ser Arg His Glu Leu Lys Asn Arg Asp Val Glu Met Gly Asn Ser 
            500                 505                 510         


Val Ile Glu Glu Asn Glu Met Lys Lys Pro Tyr Gln Leu Ile Ala Gln 
        515                 520                 525             


Asp Asn Glu Thr Glu Lys Pro Ile Asp Ser Glu Thr Lys Met 
    530                 535                 540         


<210>  2979
<211>  635
<212>  PRT
<213>  Homo sapiens

<400>  2979

Met Ala Arg Gly Leu Pro Thr Ile Ala Ser Leu Ala Arg Leu Cys Gln 
1               5                   10                  15      


Lys Leu Asn Arg Leu Lys Pro Leu Glu Asp Ser Thr Met Glu Thr Ser 
            20                  25                  30          


Leu Arg Arg Cys Leu Ser Thr Leu Asp Leu Thr Leu Leu Gly Val Gly 
        35                  40                  45              


Gly Met Val Gly Ser Gly Leu Tyr Val Leu Thr Gly Ala Val Ala Lys 
    50                  55                  60                  


Glu Val Ala Gly Pro Ala Val Leu Leu Ser Phe Gly Val Ala Ala Val 
65                  70                  75                  80  


Ala Ser Leu Leu Ala Ala Leu Cys Tyr Ala Glu Phe Gly Ala Arg Val 
                85                  90                  95      


Pro Arg Thr Gly Ser Ala Tyr Leu Phe Thr Tyr Val Ser Met Gly Glu 
            100                 105                 110         


Leu Trp Ala Phe Leu Ile Gly Trp Asn Val Leu Leu Glu Tyr Ile Ile 
        115                 120                 125             


Gly Gly Ala Ala Val Ala Arg Ala Trp Ser Gly Tyr Leu Asp Ser Met 
    130                 135                 140                 


Phe Ser His Ser Ile Arg Asn Phe Thr Glu Thr His Val Gly Ser Trp 
145                 150                 155                 160 


Gln Val Pro Leu Leu Gly His Tyr Pro Asp Phe Leu Ala Ala Gly Ile 
                165                 170                 175     


Ile Leu Leu Ala Ser Ala Phe Val Ser Cys Gly Ala Arg Val Ser Ser 
            180                 185                 190         


Trp Leu Asn His Thr Phe Ser Ala Ile Ser Leu Leu Val Ile Leu Phe 
        195                 200                 205             


Ile Val Ile Leu Gly Phe Ile Leu Ala Gln Pro His Asn Trp Ser Ala 
    210                 215                 220                 


Asp Glu Gly Gly Phe Ala Pro Phe Gly Phe Ser Gly Val Met Ala Gly 
225                 230                 235                 240 


Thr Ala Ser Cys Phe Tyr Ala Phe Val Gly Phe Asp Val Ile Ala Ala 
                245                 250                 255     


Ser Ser Glu Glu Ala Gln Asn Pro Arg Arg Ser Val Pro Leu Ala Ile 
            260                 265                 270         


Ala Ile Ser Leu Ala Ile Ala Ala Gly Ala Tyr Ile Leu Val Ser Thr 
        275                 280                 285             


Val Leu Thr Leu Met Val Pro Trp His Ser Leu Asp Pro Asp Ser Ala 
    290                 295                 300                 


Leu Ala Asp Ala Phe Tyr Gln Arg Gly Tyr Arg Trp Ala Gly Phe Ile 
305                 310                 315                 320 


Val Ala Ala Gly Ser Ile Cys Ala Met Asn Thr Val Leu Leu Ser Leu 
                325                 330                 335     


Leu Phe Ser Leu Pro Arg Ile Val Tyr Ala Met Ala Ala Asp Gly Leu 
            340                 345                 350         


Phe Phe Gln Val Phe Ala His Val His Pro Arg Thr Gln Val Pro Val 
        355                 360                 365             


Ala Gly Thr Leu Ala Phe Gly Leu Leu Thr Ala Phe Leu Ala Leu Leu 
    370                 375                 380                 


Leu Asp Leu Glu Ser Leu Val Gln Phe Leu Ser Leu Gly Thr Leu Leu 
385                 390                 395                 400 


Ala Tyr Thr Phe Val Ala Thr Ser Ile Ile Val Leu Arg Phe Gln Lys 
                405                 410                 415     


Ser Ser Pro Pro Ser Ser Pro Gly Pro Ala Ser Pro Gly Pro Leu Thr 
            420                 425                 430         


Lys Gln Gln Ser Ser Phe Ser Asp His Leu Gln Leu Val Gly Thr Val 
        435                 440                 445             


His Ala Ser Val Pro Glu Pro Gly Glu Leu Lys Pro Ala Leu Arg Pro 
    450                 455                 460                 


Tyr Leu Gly Phe Leu Asp Gly Tyr Ser Pro Gly Ala Val Val Thr Trp 
465                 470                 475                 480 


Ala Leu Gly Val Met Leu Ala Ser Ala Ile Thr Ile Gly Cys Val Leu 
                485                 490                 495     


Val Phe Gly Asn Ser Thr Leu His Leu Pro His Trp Gly Tyr Ile Leu 
            500                 505                 510         


Leu Leu Leu Leu Thr Ser Val Met Phe Leu Leu Ser Leu Leu Val Leu 
        515                 520                 525             


Gly Ala His Gln Gln Gln Tyr Arg Glu Asp Leu Phe Gln Ile Pro Met 
    530                 535                 540                 


Val Pro Leu Ile Pro Ala Leu Ser Ile Val Leu Asn Ile Cys Leu Met 
545                 550                 555                 560 


Leu Lys Leu Ser Tyr Leu Thr Trp Val Arg Phe Ser Ile Trp Leu Leu 
                565                 570                 575     


Met Gly Leu Ala Val Tyr Phe Gly Tyr Gly Ile Arg His Ser Lys Glu 
            580                 585                 590         


Asn Gln Arg Glu Leu Pro Gly Leu Asn Ser Thr His Tyr Val Val Phe 
        595                 600                 605             


Pro Arg Gly Ser Leu Glu Glu Thr Val Gln Ala Met Gln Pro Pro Ser 
    610                 615                 620                 


Gln Ala Pro Ala Gln Asp Pro Gly His Met Glu 
625                 630                 635 


<210>  2980
<211>  834
<212>  PRT
<213>  Homo sapiens

<400>  2980

Met Trp Gly Leu Gly Ala Arg Gly Pro Asp Arg Gly Leu Leu Leu Ala 
1               5                   10                  15      


Leu Ala Leu Gly Gly Leu Ala Arg Ala Gly Gly Val Glu Val Glu Pro 
            20                  25                  30          


Gly Gly Ala His Gly Glu Ser Gly Gly Phe Gln Val Val Thr Phe Glu 
        35                  40                  45              


Trp Ala His Val Gln Asp Pro Tyr Val Ile Ala Leu Trp Ile Leu Val 
    50                  55                  60                  


Ala Ser Leu Ala Lys Ile Gly Phe His Leu Ser His Lys Val Thr Ser 
65                  70                  75                  80  


Val Val Pro Glu Ser Ala Leu Leu Ile Val Leu Gly Leu Val Leu Gly 
                85                  90                  95      


Gly Ile Val Trp Ala Ala Asp His Ile Ala Ser Phe Thr Leu Thr Pro 
            100                 105                 110         


Thr Val Phe Phe Phe Tyr Leu Leu Pro Pro Ile Val Leu Asp Ala Gly 
        115                 120                 125             


Tyr Phe Met Pro Asn Arg Leu Phe Phe Gly Asn Leu Gly Thr Ile Leu 
    130                 135                 140                 


Leu Tyr Ala Val Val Gly Thr Val Trp Asn Ala Ala Thr Thr Gly Leu 
145                 150                 155                 160 


Ser Leu Tyr Gly Val Phe Leu Ser Gly Leu Met Gly Asp Leu Gln Ile 
                165                 170                 175     


Gly Leu Leu Asp Phe Leu Leu Phe Gly Ser Leu Met Ala Ala Val Asp 
            180                 185                 190         


Pro Val Ala Val Leu Ala Val Phe Glu Glu Val His Val Asn Glu Val 
        195                 200                 205             


Leu Phe Ile Ile Val Phe Gly Glu Ser Leu Leu Asn Asp Ala Val Thr 
    210                 215                 220                 


Val Val Leu Tyr Asn Val Phe Glu Ser Phe Val Ala Leu Gly Gly Asp 
225                 230                 235                 240 


Asn Val Thr Gly Val Asp Cys Val Lys Gly Ile Val Ser Phe Phe Val 
                245                 250                 255     


Val Ser Leu Gly Gly Thr Leu Val Gly Val Val Phe Ala Phe Leu Leu 
            260                 265                 270         


Ser Leu Val Thr Arg Phe Thr Lys His Val Arg Ile Ile Glu Pro Gly 
        275                 280                 285             


Phe Val Phe Ile Ile Ser Tyr Leu Ser Tyr Leu Thr Ser Glu Met Leu 
    290                 295                 300                 


Ser Leu Ser Ala Ile Leu Ala Ile Thr Phe Cys Gly Ile Cys Cys Gln 
305                 310                 315                 320 


Lys Tyr Val Lys Ala Asn Ile Ser Glu Gln Ser Ala Thr Thr Val Arg 
                325                 330                 335     


Tyr Thr Met Lys Met Leu Ala Ser Ser Ala Glu Thr Ile Ile Phe Met 
            340                 345                 350         


Phe Leu Gly Ile Ser Ala Val Asn Pro Phe Ile Trp Thr Trp Asn Thr 
        355                 360                 365             


Ala Phe Val Leu Leu Thr Leu Val Phe Ile Ser Val Tyr Arg Ala Ile 
    370                 375                 380                 


Gly Val Val Leu Gln Thr Trp Leu Leu Asn Arg Tyr Arg Met Val Gln 
385                 390                 395                 400 


Leu Glu Pro Ile Asp Gln Val Val Leu Ser Tyr Gly Gly Leu Arg Gly 
                405                 410                 415     


Ala Val Ala Phe Ala Leu Val Val Leu Leu Asp Gly Asp Lys Val Lys 
            420                 425                 430         


Glu Lys Asn Leu Phe Val Ser Thr Thr Ile Ile Val Val Phe Phe Thr 
        435                 440                 445             


Val Ile Phe Gln Gly Leu Thr Ile Lys Pro Leu Val Gln Trp Leu Lys 
    450                 455                 460                 


Val Lys Arg Ser Glu His Arg Glu Pro Arg Leu Asn Glu Lys Leu His 
465                 470                 475                 480 


Gly Arg Ala Phe Asp His Ile Leu Ser Ala Ile Glu Asp Ile Ser Gly 
                485                 490                 495     


Gln Ile Gly His Asn Tyr Leu Arg Asp Lys Trp Ser His Phe Asp Arg 
            500                 505                 510         


Lys Phe Leu Ser Arg Val Leu Met Arg Arg Ser Ala Gln Lys Ser Arg 
        515                 520                 525             


Asp Arg Ile Leu Asn Val Phe His Glu Leu Asn Leu Lys Asp Ala Ile 
    530                 535                 540                 


Ser Tyr Val Ala Glu Gly Glu Arg Arg Gly Ser Leu Ala Phe Ile Arg 
545                 550                 555                 560 


Ser Pro Ser Thr Asp Asn Val Val Asn Val Asp Phe Thr Pro Arg Ser 
                565                 570                 575     


Ser Thr Val Glu Ala Ser Val Ser Tyr Leu Leu Arg Glu Asn Val Ser 
            580                 585                 590         


Ala Val Cys Leu Asp Met Gln Ser Leu Glu Gln Arg Arg Arg Ser Ile 
        595                 600                 605             


Arg Asp Ala Glu Asp Met Val Thr His His Thr Leu Gln Gln Tyr Leu 
    610                 615                 620                 


Tyr Lys Pro Arg Gln Glu Tyr Lys His Leu Tyr Ser Arg His Glu Leu 
625                 630                 635                 640 


Thr Pro Thr Glu Asp Glu Lys Gln Asp Arg Glu Ile Phe His Arg Thr 
                645                 650                 655     


Met Arg Lys Arg Leu Glu Ser Phe Lys Ser Thr Lys Leu Gly Leu Asn 
            660                 665                 670         


Gln Asn Lys Lys Ala Ala Lys Leu Tyr Lys Arg Glu Arg Ala Gln Lys 
        675                 680                 685             


Arg Arg Asn Ser Ser Ile Pro Asn Gly Lys Leu Pro Met Glu Ser Pro 
    690                 695                 700                 


Ala Gln Asn Phe Thr Ile Lys Glu Lys Asp Leu Glu Leu Ser Asp Thr 
705                 710                 715                 720 


Glu Glu Pro Pro Asn Tyr Asp Glu Glu Met Ser Gly Gly Ile Glu Phe 
                725                 730                 735     


Leu Ala Ser Val Thr Lys Asp Thr Ala Ser Asp Ser Pro Ala Gly Ile 
            740                 745                 750         


Asp Asn Pro Val Phe Ser Pro Asp Glu Ala Leu Asp Arg Ser Leu Leu 
        755                 760                 765             


Ala Arg Leu Pro Pro Trp Leu Ser Pro Gly Glu Thr Val Val Pro Ser 
    770                 775                 780                 


Gln Arg Ala Arg Thr Gln Ile Pro Tyr Ser Pro Gly Thr Phe Cys Arg 
785                 790                 795                 800 


Leu Met Pro Phe Arg Leu Ser Ser Lys Ser Val Asp Ser Phe Leu Gln 
                805                 810                 815     


Ala Asp Gly Pro Glu Glu Arg Pro Pro Ala Ala Leu Pro Glu Ser Thr 
            820                 825                 830         


His Met 
        


<210>  2981
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  2981

Met Lys Asp Arg Leu Glu Gln Leu Lys Ala Lys Gln Leu Thr Gln Asp 
1               5                   10                  15      


Asp Asp Thr Asp Ala Val Glu Ile Ala Ile Asp Asn Thr Ala Phe Met 
            20                  25                  30          


Asp Glu Phe Phe Ser Glu Ile Glu Glu Thr Arg Leu Asn Ile Asp Lys 
        35                  40                  45              


Ile Ser Glu His Val Glu Glu Ala Lys Lys Leu Tyr Ser Ile Ile Leu 
    50                  55                  60                  


Ser Ala Pro Ile Pro Glu Pro Lys Thr Lys Asp Asp Leu Glu Gln Leu 
65                  70                  75                  80  


Thr Thr Glu Ile Lys Lys Arg Ala Asn Asn Val Arg Asn Lys Leu Lys 
                85                  90                  95      


Ser Met Glu Lys His Ile Glu Glu Asp Glu Val Arg Ser Ser Ala Asp 
            100                 105                 110         


Leu Arg Ile Arg Lys Ser Gln His Ser Val Leu Ser Arg Lys Phe Val 
        115                 120                 125             


Glu Val Met Thr Lys Tyr Asn Glu Ala Gln Val Asp Phe Arg Glu Arg 
    130                 135                 140                 


Ser Lys Gly Arg Ile Gln Arg Gln Leu Glu Ile Thr Gly Lys Lys Thr 
145                 150                 155                 160 


Thr Asp Glu Glu Leu Glu Glu Met Leu Glu Ser Gly Asn Pro Ala Ile 
                165                 170                 175     


Phe Thr Ser Gly Ile Ile Asp Ser Gln Ile Ser Lys Gln Ala Leu Ser 
            180                 185                 190         


Glu Ile Glu Gly Arg His Lys Asp Ile Val Arg Leu Glu Ser Ser Ile 
        195                 200                 205             


Lys Glu Leu His Asp Met Phe Met Asp Ile Ala Met Leu Val Glu Asn 
    210                 215                 220                 


Gln Gly Glu Met Leu Asp Asn Ile Glu Leu Asn Val Met His Thr Val 
225                 230                 235                 240 


Asp His Val Glu Lys Ala Arg Asp Glu Thr Lys Lys Ala Val Lys Tyr 
                245                 250                 255     


Gln Ser Gln Ala Arg Lys Lys Leu Ile Ile Ile Ile Val Leu Val Val 
            260                 265                 270         


Val Leu Leu Gly Ile Leu Ala Leu Ile Ile Gly Leu Ser Val Gly Leu 
        275                 280                 285             


Asn 
    


<210>  2982
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  2982

Met Thr Ile Thr Tyr Thr Ser Gln Val Ala Asn Ala Arg Leu Gly Ser 
1               5                   10                  15      


Phe Ser Arg Leu Leu Leu Cys Trp Arg Gly Ser Ile Tyr Lys Leu Leu 
            20                  25                  30          


Tyr Gly Glu Phe Leu Ile Phe Leu Leu Cys Tyr Tyr Ile Ile Arg Phe 
        35                  40                  45              


Ile Tyr Arg Leu Ala Leu Thr Glu Glu Gln Gln Leu Met Phe Glu Lys 
    50                  55                  60                  


Leu Thr Leu Tyr Cys Asp Ser Tyr Ile Gln Leu Ile Pro Ile Ser Phe 
65                  70                  75                  80  


Val Leu Gly Phe Tyr Val Thr Leu Val Val Thr Arg Trp Trp Asn Gln 
                85                  90                  95      


Tyr Glu Asn Leu Pro Trp Pro Asp Arg Leu Met Ser Leu Val Ser Gly 
            100                 105                 110         


Phe Val Glu Gly Lys Asp Glu Gln Gly Arg Leu Leu Arg Arg Thr Leu 
        115                 120                 125             


Ile Arg Tyr Ala Asn Leu Gly Asn Val Leu Ile Leu Arg Ser Val Ser 
    130                 135                 140                 


Thr Ala Val Tyr Lys Arg Phe Pro Ser Ala Gln His Leu Val Gln Ala 
145                 150                 155                 160 


Gly Phe Met Thr Pro Ala Glu His Lys Gln Leu Glu Lys Leu Ser Leu 
                165                 170                 175     


Pro His Asn Met Phe Trp Val Pro Trp Val Trp Phe Ala Asn Leu Ser 
            180                 185                 190         


Met Lys Ala Trp Leu Gly Gly Arg Ile Arg Asp Pro Ile Leu Leu Gln 
        195                 200                 205             


Ser Leu Leu Asn Glu Met Asn Thr Leu Arg Thr Gln Cys Gly His Leu 
    210                 215                 220                 


Tyr Ala Tyr Asp Trp Ile Ser Ile Pro Leu Val Tyr Thr Gln Val Val 
225                 230                 235                 240 


Thr Val Ala Val Tyr Ser Phe Phe Leu Thr Cys Leu Val Gly Arg Gln 
                245                 250                 255     


Phe Leu Asn Pro Ala Lys Ala Tyr Pro Gly His Glu Leu Asp Leu Val 
            260                 265                 270         


Val Pro Val Phe Thr Phe Leu Gln Phe Phe Phe Tyr Val Gly Trp Leu 
        275                 280                 285             


Lys Val Ala Glu Gln Leu Ile Asn Pro Phe Gly Glu Asp Asp Asp Asp 
    290                 295                 300                 


Phe Glu Thr Asn Trp Ile Val Asp Arg Asn Leu Gln Val Ser Leu Leu 
305                 310                 315                 320 


Ala Val Asp Glu Met His Gln Asp Leu Pro Arg Met Glu Pro Asp Met 
                325                 330                 335     


Tyr Trp Asn Lys Pro Glu Pro Gln Pro Pro Tyr Thr Ala Ala Ser Ala 
            340                 345                 350         


Gln Phe Arg Arg Ala Ser Phe Met Gly Ser Thr Phe Asn Ile Ser Leu 
        355                 360                 365             


Asn Lys Glu Glu Met Glu Phe Gln Pro Asn Gln Glu Asp Glu Glu Asp 
    370                 375                 380                 


Ala His Ala Gly Ile Ile Gly Arg Phe Leu Gly Leu Gln Ser His Asp 
385                 390                 395                 400 


His His Pro Pro Arg Ala Asn Ser Arg Thr Lys Leu Leu Trp Pro Lys 
                405                 410                 415     


Arg Glu Ser Leu Leu His Glu Gly Leu Pro Lys Asn His Lys Ala Ala 
            420                 425                 430         


Lys Gln Asn Val Arg Gly Gln Glu Asp Asn Lys Ala Trp Lys Leu Lys 
        435                 440                 445             


Ala Val Asp Ala Phe Lys Ser Ala Pro Leu Tyr Gln Arg Pro Gly Tyr 
    450                 455                 460                 


Tyr Ser Ala Pro Gln Thr Pro Leu Ser Pro Thr Pro Met Phe Phe Pro 
465                 470                 475                 480 


Leu Glu Pro Ser Ala Pro Ser Lys Leu His Ser Val Thr Gly Ile Asp 
                485                 490                 495     


Thr Lys Asp Lys Ser Leu Lys Thr Val Ser Ser Gly Ala Lys Lys Ser 
            500                 505                 510         


Phe Glu Leu Leu Ser Glu Ser Asp Gly Ala Leu Met Glu His Pro Glu 
        515                 520                 525             


Val Ser Gln Val Arg Arg Lys Thr Val Glu Phe Asn Leu Thr Asp Met 
    530                 535                 540                 


Pro Glu Ile Pro Glu Asn His Leu Lys Glu Pro Leu Glu Gln Ser Pro 
545                 550                 555                 560 


Thr Asn Ile His Thr Thr Leu Lys Asp His Met Asp Pro Tyr Trp Ala 
                565                 570                 575     


Leu Glu Asn Arg Asp Glu Ala His Ser 
            580                 585 


<210>  2983
<211>  859
<212>  PRT
<213>  Homo sapiens

<400>  2983

Met Gln Ala Ala Val Ala Val Ser Val Pro Phe Leu Leu Leu Cys Val 
1               5                   10                  15      


Leu Gly Thr Cys Pro Pro Ala Arg Cys Gly Gln Ala Gly Asp Ala Ser 
            20                  25                  30          


Leu Met Glu Leu Glu Lys Arg Lys Glu Asn Arg Phe Val Glu Arg Gln 
        35                  40                  45              


Ser Ile Val Pro Leu Arg Leu Ile Tyr Arg Ser Gly Gly Glu Asp Glu 
    50                  55                  60                  


Ser Arg His Asp Ala Leu Asp Thr Arg Val Arg Gly Asp Leu Gly Gly 
65                  70                  75                  80  


Pro Gln Leu Thr His Val Asp Gln Ala Ser Phe Gln Val Asp Ala Phe 
                85                  90                  95      


Gly Thr Ser Phe Ile Leu Asp Val Val Leu Asn His Asp Leu Leu Ser 
            100                 105                 110         


Ser Glu Tyr Ile Glu Arg His Ile Glu His Gly Gly Lys Thr Val Glu 
        115                 120                 125             


Val Lys Gly Gly Glu His Cys Tyr Tyr Gln Gly His Ile Arg Gly Asn 
    130                 135                 140                 


Pro Asp Ser Phe Val Ala Leu Ser Thr Cys His Gly Leu His Gly Met 
145                 150                 155                 160 


Phe Tyr Asp Gly Asn His Thr Tyr Leu Ile Glu Pro Glu Glu Asn Asp 
                165                 170                 175     


Thr Thr Gln Glu Asp Phe His Phe His Ser Val Tyr Lys Ser Arg Leu 
            180                 185                 190         


Phe Glu Phe Ser Leu Asp Asp Leu Pro Ser Glu Phe Gln Gln Val Asn 
        195                 200                 205             


Ile Thr Pro Ser Lys Phe Ile Leu Lys Pro Arg Pro Lys Arg Ser Lys 
    210                 215                 220                 


Arg Gln Leu Arg Arg Tyr Pro Arg Asn Val Glu Glu Glu Thr Lys Tyr 
225                 230                 235                 240 


Ile Glu Leu Met Ile Val Asn Asp His Leu Met Phe Lys Lys His Arg 
                245                 250                 255     


Leu Ser Val Val His Thr Asn Thr Tyr Ala Lys Ser Val Val Asn Met 
            260                 265                 270         


Ala Asp Leu Ile Tyr Lys Asp Gln Leu Lys Thr Arg Ile Val Leu Val 
        275                 280                 285             


Ala Met Glu Thr Trp Ala Thr Asp Asn Lys Phe Ala Ile Ser Glu Asn 
    290                 295                 300                 


Pro Leu Ile Thr Leu Arg Glu Phe Met Lys Tyr Arg Arg Asp Phe Ile 
305                 310                 315                 320 


Lys Glu Lys Ser Asp Ala Val His Leu Phe Ser Gly Ser Gln Phe Glu 
                325                 330                 335     


Ser Ser Arg Ser Gly Ala Ala Tyr Ile Gly Gly Ile Cys Ser Leu Leu 
            340                 345                 350         


Lys Gly Gly Gly Val Asn Glu Phe Gly Lys Thr Asp Leu Met Ala Val 
        355                 360                 365             


Thr Leu Ala Gln Ser Leu Ala His Asn Ile Gly Ile Ile Ser Asp Lys 
    370                 375                 380                 


Arg Lys Leu Ala Ser Gly Glu Cys Lys Cys Glu Asp Thr Trp Ser Gly 
385                 390                 395                 400 


Cys Ile Met Gly Asp Thr Gly Tyr Tyr Leu Pro Lys Lys Phe Thr Gln 
                405                 410                 415     


Cys Asn Ile Glu Glu Tyr His Asp Phe Leu Asn Ser Gly Gly Gly Ala 
            420                 425                 430         


Cys Leu Phe Asn Lys Pro Ser Lys Leu Leu Asp Pro Pro Glu Cys Gly 
        435                 440                 445             


Asn Gly Phe Ile Glu Thr Gly Glu Glu Cys Asp Cys Gly Thr Pro Ala 
    450                 455                 460                 


Glu Cys Val Leu Glu Gly Ala Glu Cys Cys Lys Lys Cys Thr Leu Thr 
465                 470                 475                 480 


Gln Asp Ser Gln Cys Ser Asp Gly Leu Cys Cys Lys Lys Cys Lys Phe 
                485                 490                 495     


Gln Pro Met Gly Thr Val Cys Arg Glu Ala Val Asn Asp Cys Asp Ile 
            500                 505                 510         


Arg Glu Thr Cys Ser Gly Asn Ser Ser Gln Cys Ala Pro Asn Ile His 
        515                 520                 525             


Lys Met Asp Gly Tyr Ser Cys Asp Gly Val Gln Gly Ile Cys Phe Gly 
    530                 535                 540                 


Gly Arg Cys Lys Thr Arg Asp Arg Gln Cys Lys Tyr Ile Trp Gly Gln 
545                 550                 555                 560 


Lys Val Thr Ala Ser Asp Lys Tyr Cys Tyr Glu Lys Leu Asn Ile Glu 
                565                 570                 575     


Gly Thr Glu Lys Gly Asn Cys Gly Lys Asp Lys Asp Thr Trp Ile Gln 
            580                 585                 590         


Cys Asn Lys Arg Asp Val Leu Cys Gly Tyr Leu Leu Cys Thr Asn Ile 
        595                 600                 605             


Gly Asn Ile Pro Arg Leu Gly Glu Leu Asp Gly Glu Ile Thr Ser Thr 
    610                 615                 620                 


Leu Val Val Gln Gln Gly Arg Thr Leu Asn Cys Ser Gly Gly His Val 
625                 630                 635                 640 


Lys Leu Glu Glu Asp Val Asp Leu Gly Tyr Val Glu Asp Gly Thr Pro 
                645                 650                 655     


Cys Gly Pro Gln Met Met Cys Leu Glu His Arg Cys Leu Pro Val Ala 
            660                 665                 670         


Ser Phe Asn Phe Ser Thr Cys Leu Ser Ser Lys Glu Gly Thr Ile Cys 
        675                 680                 685             


Ser Gly Asn Gly Val Cys Ser Asn Glu Leu Lys Cys Val Cys Asn Arg 
    690                 695                 700                 


His Trp Ile Gly Ser Asp Cys Asn Thr Tyr Phe Pro His Asn Asp Asp 
705                 710                 715                 720 


Ala Lys Thr Gly Ile Thr Leu Ser Gly Asn Gly Val Ala Gly Thr Asn 
                725                 730                 735     


Ile Ile Ile Gly Ile Ile Ala Gly Thr Ile Leu Val Leu Ala Leu Ile 
            740                 745                 750         


Leu Gly Ile Thr Ala Trp Gly Tyr Lys Asn Tyr Arg Glu Gln Arg Gln 
        755                 760                 765             


Leu Pro Gln Gly Asp Tyr Val Lys Lys Pro Gly Asp Gly Asp Ser Phe 
    770                 775                 780                 


Tyr Ser Asp Ile Pro Pro Gly Val Ser Thr Asn Ser Ala Ser Ser Ser 
785                 790                 795                 800 


Lys Lys Arg Ser Asn Gly Leu Ser His Ser Trp Ser Glu Arg Ile Pro 
                805                 810                 815     


Asp Thr Lys His Ile Ser Asp Ile Cys Glu Asn Gly Arg Pro Arg Ser 
            820                 825                 830         


Asn Ser Trp Gln Gly Asn Leu Gly Gly Asn Lys Lys Lys Ile Arg Gly 
        835                 840                 845             


Lys Arg Phe Arg Pro Arg Ser Asn Ser Thr Glu 
    850                 855                 


<210>  2984
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  2984

Met Ala Gln His Gly Ala Met Gly Ala Phe Arg Ala Leu Cys Gly Leu 
1               5                   10                  15      


Ala Leu Leu Cys Ala Leu Ser Leu Gly Gln Arg Pro Thr Gly Gly Pro 
            20                  25                  30          


Gly Cys Gly Pro Gly Arg Leu Leu Leu Gly Thr Gly Thr Asp Ala Arg 
        35                  40                  45              


Cys Cys Arg Val His Thr Thr Arg Cys Cys Arg Asp Tyr Pro Gly Glu 
    50                  55                  60                  


Glu Cys Cys Ser Glu Trp Asp Cys Met Cys Val Gln Pro Glu Phe His 
65                  70                  75                  80  


Cys Gly Asp Pro Cys Cys Thr Thr Cys Arg His His Pro Cys Pro Pro 
                85                  90                  95      


Gly Gln Gly Val Gln Ser Gln Gly Lys Phe Ser Phe Gly Phe Gln Cys 
            100                 105                 110         


Ile Asp Cys Ala Ser Gly Thr Phe Ser Gly Gly His Glu Gly His Cys 
        115                 120                 125             


Lys Pro Trp Thr Asp Cys Thr Gln Phe Gly Phe Leu Thr Val Phe Pro 
    130                 135                 140                 


Gly Asn Lys Thr His Asn Ala Val Cys Val Pro Gly Ser Pro Pro Ala 
145                 150                 155                 160 


Glu Pro Leu Gly Trp Leu Thr Val Val Leu Leu Ala Val Ala Ala Cys 
                165                 170                 175     


Val Leu Leu Leu Thr Ser Ala Gln Leu Gly Leu His Ile Trp Gln Leu 
            180                 185                 190         


Arg Ser Gln Cys Met Trp Pro Arg Glu Thr Gln Leu Leu Leu Glu Val 
        195                 200                 205             


Pro Pro Ser Thr Glu Asp Ala Arg Ser Cys Gln Phe Pro Glu Glu Glu 
    210                 215                 220                 


Arg Gly Glu Arg Ser Ala Glu Glu Lys Gly Arg Leu Gly Asp Leu Trp 
225                 230                 235                 240 


Val 
    


<210>  2985
<211>  535
<212>  PRT
<213>  Homo sapiens

<400>  2985

Met Lys Leu Trp Val Ser Ala Leu Leu Met Ala Trp Phe Gly Val Leu 
1               5                   10                  15      


Ser Cys Val Gln Ala Glu Phe Phe Thr Ser Ile Gly His Met Thr Asp 
            20                  25                  30          


Leu Ile Tyr Ala Glu Lys Glu Leu Val Gln Ser Leu Lys Glu Tyr Ile 
        35                  40                  45              


Leu Val Glu Glu Ala Lys Leu Ser Lys Ile Lys Ser Trp Ala Asn Lys 
    50                  55                  60                  


Met Glu Ala Leu Thr Ser Lys Ser Ala Ala Asp Ala Glu Gly Tyr Leu 
65                  70                  75                  80  


Ala His Pro Val Asn Ala Tyr Lys Leu Val Lys Arg Leu Asn Thr Asp 
                85                  90                  95      


Trp Pro Ala Leu Glu Asp Leu Val Leu Gln Asp Ser Ala Ala Gly Phe 
            100                 105                 110         


Ile Ala Asn Leu Ser Val Gln Arg Gln Phe Phe Pro Thr Asp Glu Asp 
        115                 120                 125             


Glu Ile Gly Ala Ala Lys Ala Leu Met Arg Leu Gln Asp Thr Tyr Arg 
    130                 135                 140                 


Leu Asp Pro Gly Thr Ile Ser Arg Gly Glu Leu Pro Gly Thr Lys Tyr 
145                 150                 155                 160 


Gln Ala Met Leu Ser Val Asp Asp Cys Phe Gly Met Gly Arg Ser Ala 
                165                 170                 175     


Tyr Asn Glu Gly Asp Tyr Tyr His Thr Val Leu Trp Met Glu Gln Val 
            180                 185                 190         


Leu Lys Gln Leu Asp Ala Gly Glu Glu Ala Thr Thr Thr Lys Ser Gln 
        195                 200                 205             


Val Leu Asp Tyr Leu Ser Tyr Ala Val Phe Gln Leu Gly Asp Leu His 
    210                 215                 220                 


Arg Ala Leu Glu Leu Thr Arg Arg Leu Leu Ser Leu Asp Pro Ser His 
225                 230                 235                 240 


Glu Arg Ala Gly Gly Asn Leu Arg Tyr Phe Glu Gln Leu Leu Glu Glu 
                245                 250                 255     


Glu Arg Glu Lys Thr Leu Thr Asn Gln Thr Glu Ala Glu Leu Ala Thr 
            260                 265                 270         


Pro Glu Gly Ile Tyr Glu Arg Pro Val Asp Tyr Leu Pro Glu Arg Asp 
        275                 280                 285             


Val Tyr Glu Ser Leu Cys Arg Gly Glu Gly Val Lys Leu Thr Pro Arg 
    290                 295                 300                 


Arg Gln Lys Arg Leu Phe Cys Arg Tyr His His Gly Asn Arg Ala Pro 
305                 310                 315                 320 


Gln Leu Leu Ile Ala Pro Phe Lys Glu Glu Asp Glu Trp Asp Ser Pro 
                325                 330                 335     


His Ile Val Arg Tyr Tyr Asp Val Met Ser Asp Glu Glu Ile Glu Arg 
            340                 345                 350         


Ile Lys Glu Ile Ala Lys Pro Lys Leu Ala Arg Ala Thr Val Arg Asp 
        355                 360                 365             


Pro Lys Thr Gly Val Leu Thr Val Ala Ser Tyr Arg Val Ser Lys Ser 
    370                 375                 380                 


Ser Trp Leu Glu Glu Asp Asp Asp Pro Val Val Ala Arg Val Asn Arg 
385                 390                 395                 400 


Arg Met Gln His Ile Thr Gly Leu Thr Val Lys Thr Ala Glu Leu Leu 
                405                 410                 415     


Gln Val Ala Asn Tyr Gly Val Gly Gly Gln Tyr Glu Pro His Phe Asp 
            420                 425                 430         


Phe Ser Arg Asn Asp Glu Arg Asp Thr Phe Lys His Leu Gly Thr Gly 
        435                 440                 445             


Asn Arg Val Ala Thr Phe Leu Asn Tyr Met Ser Asp Val Glu Ala Gly 
    450                 455                 460                 


Gly Ala Thr Val Phe Pro Asp Leu Gly Ala Ala Ile Trp Pro Lys Lys 
465                 470                 475                 480 


Gly Thr Ala Val Phe Trp Tyr Asn Leu Leu Arg Ser Gly Glu Gly Asp 
                485                 490                 495     


Tyr Arg Thr Arg His Ala Ala Cys Pro Val Leu Val Gly Cys Lys Trp 
            500                 505                 510         


Val Ser Asn Lys Trp Phe His Glu Arg Gly Gln Glu Phe Leu Arg Pro 
        515                 520                 525             


Cys Gly Ser Thr Glu Val Asp 
    530                 535 


<210>  2986
<211>  581
<212>  PRT
<213>  Homo sapiens

<400>  2986

Met Val Leu Lys Ala Phe Phe Pro Thr Cys Cys Val Ser Thr Asp Ser 
1               5                   10                  15      


Gly Leu Leu Val Gly Arg Trp Val Pro Glu Gln Ser Ser Ala Val Val 
            20                  25                  30          


Leu Ala Val Leu His Phe Pro Phe Ile Pro Ile Gln Val Lys Gln Leu 
        35                  40                  45              


Leu Ala Gln Val Arg Gln Ala Ser Gln Val Gly Val Ala Val Leu Gly 
    50                  55                  60                  


Thr Trp Cys His Cys Arg Gln Glu Pro Glu Glu Ser Leu Gly Arg Phe 
65                  70                  75                  80  


Leu Glu Ser Leu Gly Ala Val Phe Pro His Glu Pro Trp Leu Arg Leu 
                85                  90                  95      


Cys Arg Glu Arg Gly Gly Thr Phe Trp Ser Cys Glu Ala Thr His Arg 
            100                 105                 110         


Gln Ala Pro Thr Ala Pro Gly Ala Pro Gly Glu Asp Gln Val Met Leu 
        115                 120                 125             


Ile Phe Tyr Asp Gln Arg Gln Val Leu Leu Ser Gln Leu His Leu Pro 
    130                 135                 140                 


Thr Val Leu Pro Asp Arg Gln Ala Gly Ala Thr Thr Ala Ser Thr Gly 
145                 150                 155                 160 


Gly Leu Ala Ala Val Phe Asp Thr Val Ala Arg Ser Glu Val Leu Phe 
                165                 170                 175     


Arg Ser Asp Arg Phe Asp Glu Gly Pro Val Arg Leu Ser His Trp Gln 
            180                 185                 190         


Ser Glu Gly Val Glu Ala Ser Ile Leu Ala Glu Leu Ala Arg Arg Ala 
        195                 200                 205             


Ser Gly Pro Ile Cys Leu Leu Leu Ala Ser Leu Leu Ser Leu Val Ser 
    210                 215                 220                 


Ala Val Ser Ala Cys Arg Val Phe Lys Leu Trp Pro Leu Ser Phe Leu 
225                 230                 235                 240 


Gly Ser Lys Leu Ser Thr Cys Glu Gln Leu Arg His Arg Leu Glu His 
                245                 250                 255     


Leu Thr Leu Ile Phe Ser Thr Arg Lys Ala Glu Asn Pro Ala Gln Leu 
            260                 265                 270         


Met Arg Lys Ala Asn Thr Val Ala Ser Val Leu Leu Asp Val Ala Leu 
        275                 280                 285             


Gly Leu Met Leu Leu Ser Trp Leu His Gly Arg Ser Arg Ile Gly His 
    290                 295                 300                 


Leu Ala Asp Ala Leu Val Pro Val Ala Asp His Val Ala Glu Glu Leu 
305                 310                 315                 320 


Gln His Leu Leu Gln Trp Leu Met Gly Ala Pro Ala Gly Leu Lys Met 
                325                 330                 335     


Asn Arg Ala Leu Asp Gln Val Leu Gly Arg Phe Phe Leu Tyr His Ile 
            340                 345                 350         


His Leu Trp Ile Ser Tyr Ile His Leu Met Ser Pro Phe Val Glu His 
        355                 360                 365             


Ile Leu Trp His Val Gly Leu Ser Ala Cys Leu Gly Leu Thr Val Ala 
    370                 375                 380                 


Leu Ser Leu Leu Ser Asp Ile Ile Ala Leu Leu Thr Phe His Ile Tyr 
385                 390                 395                 400 


Cys Phe Tyr Val Tyr Gly Ala Arg Leu Tyr Cys Leu Lys Ile His Gly 
                405                 410                 415     


Leu Ser Ser Leu Trp Arg Leu Phe Arg Gly Lys Lys Trp Asn Val Leu 
            420                 425                 430         


Arg Gln Arg Val Asp Ser Cys Ser Tyr Asp Leu Asp Gln Leu Phe Ile 
        435                 440                 445             


Gly Thr Leu Leu Phe Thr Ile Leu Leu Phe Leu Leu Pro Thr Thr Ala 
    450                 455                 460                 


Leu Tyr Tyr Leu Val Phe Thr Leu Leu Arg Leu Leu Val Val Ala Val 
465                 470                 475                 480 


Gln Gly Leu Ile His Leu Leu Val Asp Leu Ile Asn Ser Leu Pro Leu 
                485                 490                 495     


Tyr Ser Leu Gly Leu Arg Leu Cys Arg Pro Tyr Arg Leu Ala Ala Gly 
            500                 505                 510         


Val Lys Phe Arg Val Leu Arg His Glu Ala Gly Arg Pro Leu Arg Leu 
        515                 520                 525             


Leu Met Gln Ile Asn Pro Leu Pro Tyr Ser Arg Val Val His Thr Tyr 
    530                 535                 540                 


Arg Leu Pro Ser Cys Gly Cys His Pro Lys His Ser Trp Gly Ala Leu 
545                 550                 555                 560 


Cys Arg Lys Leu Phe Leu Gly Glu Leu Ile Tyr Pro Trp Arg Gln Arg 
                565                 570                 575     


Gly Asp Lys Gln Asp 
            580     


<210>  2987
<211>  613
<212>  PRT
<213>  Homo sapiens

<400>  2987

Met Phe Arg Cys Gly Gly Leu Ala Ala Gly Ala Leu Lys Gln Lys Leu 
1               5                   10                  15      


Val Pro Leu Val Arg Thr Val Cys Val Arg Ser Pro Arg Gln Arg Asn 
            20                  25                  30          


Arg Leu Pro Gly Asn Leu Phe Gln Arg Trp His Val Pro Leu Glu Leu 
        35                  40                  45              


Gln Met Thr Arg Gln Met Ala Ser Ser Gly Ala Ser Gly Gly Lys Ile 
    50                  55                  60                  


Asp Asn Ser Val Leu Val Leu Ile Val Gly Leu Ser Thr Val Gly Ala 
65                  70                  75                  80  


Gly Ala Tyr Ala Tyr Lys Thr Met Lys Glu Asp Glu Lys Arg Tyr Asn 
                85                  90                  95      


Glu Arg Ile Ser Gly Leu Gly Leu Thr Pro Glu Gln Lys Gln Lys Lys 
            100                 105                 110         


Ala Ala Leu Ser Ala Ser Glu Gly Glu Glu Val Pro Gln Asp Lys Ala 
        115                 120                 125             


Pro Ser His Val Pro Phe Leu Leu Ile Gly Gly Gly Thr Ala Ala Phe 
    130                 135                 140                 


Ala Ala Ala Arg Ser Ile Arg Ala Arg Asp Pro Gly Ala Arg Val Leu 
145                 150                 155                 160 


Ile Val Ser Glu Asp Pro Glu Leu Pro Tyr Met Arg Pro Pro Leu Ser 
                165                 170                 175     


Lys Glu Leu Trp Phe Ser Asp Asp Pro Asn Val Thr Lys Thr Leu Arg 
            180                 185                 190         


Phe Lys Gln Trp Asn Gly Lys Glu Arg Ser Ile Tyr Phe Gln Pro Pro 
        195                 200                 205             


Ser Phe Tyr Val Ser Ala Gln Asp Leu Pro His Ile Glu Asn Gly Gly 
    210                 215                 220                 


Val Ala Val Leu Thr Gly Lys Lys Val Val Gln Leu Asp Val Arg Asp 
225                 230                 235                 240 


Asn Met Val Lys Leu Asn Asp Gly Ser Gln Ile Thr Tyr Glu Lys Cys 
                245                 250                 255     


Leu Ile Ala Thr Gly Gly Thr Pro Arg Ser Leu Ser Ala Ile Asp Arg 
            260                 265                 270         


Ala Gly Ala Glu Val Lys Ser Arg Thr Thr Leu Phe Arg Lys Ile Gly 
        275                 280                 285             


Asp Phe Arg Ser Leu Glu Lys Ile Ser Arg Glu Val Lys Ser Ile Thr 
    290                 295                 300                 


Ile Ile Gly Gly Gly Phe Leu Gly Ser Glu Leu Ala Cys Ala Leu Gly 
305                 310                 315                 320 


Arg Lys Ala Arg Ala Leu Gly Thr Glu Val Ile Gln Leu Phe Pro Glu 
                325                 330                 335     


Lys Gly Asn Met Gly Lys Ile Leu Pro Glu Tyr Leu Ser Asn Trp Thr 
            340                 345                 350         


Met Glu Lys Val Arg Arg Glu Gly Val Lys Val Met Pro Asn Ala Ile 
        355                 360                 365             


Val Gln Ser Val Gly Val Ser Ser Gly Lys Leu Leu Ile Lys Leu Lys 
    370                 375                 380                 


Asp Gly Arg Lys Val Glu Thr Asp His Ile Val Ala Ala Val Gly Leu 
385                 390                 395                 400 


Glu Pro Asn Val Glu Leu Ala Lys Thr Gly Gly Leu Glu Ile Asp Ser 
                405                 410                 415     


Asp Phe Gly Gly Phe Arg Val Asn Ala Glu Leu Gln Ala Arg Ser Asn 
            420                 425                 430         


Ile Trp Val Ala Gly Asp Ala Ala Cys Phe Tyr Asp Ile Lys Leu Gly 
        435                 440                 445             


Arg Arg Arg Val Glu His His Asp His Ala Val Val Ser Gly Arg Leu 
    450                 455                 460                 


Ala Gly Glu Asn Met Thr Gly Ala Ala Lys Pro Tyr Trp His Gln Ser 
465                 470                 475                 480 


Met Phe Trp Ser Asp Leu Gly Pro Asp Val Gly Tyr Glu Ala Ile Gly 
                485                 490                 495     


Leu Val Asp Ser Ser Leu Pro Thr Val Gly Val Phe Ala Lys Ala Thr 
            500                 505                 510         


Ala Gln Asp Asn Pro Lys Ser Ala Thr Glu Gln Ser Gly Thr Gly Ile 
        515                 520                 525             


Arg Ser Glu Ser Glu Thr Glu Ser Glu Ala Ser Glu Ile Thr Ile Pro 
    530                 535                 540                 


Pro Ser Thr Pro Ala Val Pro Gln Ala Pro Val Gln Gly Glu Asp Tyr 
545                 550                 555                 560 


Gly Lys Gly Val Ile Phe Tyr Leu Arg Asp Lys Val Val Val Gly Ile 
                565                 570                 575     


Val Leu Trp Asn Ile Phe Asn Arg Met Pro Ile Ala Arg Lys Ile Ile 
            580                 585                 590         


Lys Asp Gly Glu Gln His Glu Asp Leu Asn Glu Val Ala Lys Leu Phe 
        595                 600                 605             


Asn Ile His Glu Asp 
    610             


<210>  2988
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  2988

Met Glu Thr Arg Pro Arg Leu Gly Ala Thr Cys Leu Leu Gly Phe Ser 
1               5                   10                  15      


Phe Leu Leu Leu Val Ile Ser Ser Asp Gly His Asn Gly Leu Gly Lys 
            20                  25                  30          


Gly Phe Gly Asp His Ile His Trp Arg Thr Leu Glu Asp Gly Lys Lys 
        35                  40                  45              


Glu Ala Ala Ala Ser Gly Leu Pro Leu Met Val Ile Ile His Lys Ser 
    50                  55                  60                  


Trp Cys Gly Ala Cys Lys Ala Leu Lys Pro Lys Phe Ala Glu Ser Thr 
65                  70                  75                  80  


Glu Ile Ser Glu Leu Ser His Asn Phe Val Met Val Asn Leu Glu Asp 
                85                  90                  95      


Glu Glu Glu Pro Lys Asp Glu Asp Phe Ser Pro Asp Gly Gly Tyr Ile 
            100                 105                 110         


Pro Arg Ile Leu Phe Leu Asp Pro Ser Gly Lys Val His Pro Glu Ile 
        115                 120                 125             


Ile Asn Glu Asn Gly Asn Pro Ser Tyr Lys Tyr Phe Tyr Val Ser Ala 
    130                 135                 140                 


Glu Gln Val Val Gln Gly Met Lys Glu Ala Gln Glu Arg Leu Thr Gly 
145                 150                 155                 160 


Asp Ala Phe Arg Lys Lys His Leu Glu Asp Glu Leu 
                165                 170         


<210>  2989
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  2989

Met Glu Gly Ala Ser Phe Gly Ala Gly Arg Ala Gly Ala Ala Leu Asp 
1               5                   10                  15      


Pro Val Ser Phe Ala Arg Arg Pro Gln Thr Leu Leu Arg Val Ala Ser 
            20                  25                  30          


Trp Val Phe Ser Ile Ala Val Phe Gly Pro Ile Val Asn Glu Gly Tyr 
        35                  40                  45              


Val Asn Thr Asp Ser Gly Pro Glu Leu Arg Cys Val Phe Asn Gly Asn 
    50                  55                  60                  


Ala Gly Ala Cys Arg Phe Gly Val Ala Leu Gly Leu Gly Ala Phe Leu 
65                  70                  75                  80  


Ala Cys Ala Ala Phe Leu Leu Leu Asp Val Arg Phe Gln Gln Ile Ser 
                85                  90                  95      


Ser Val Arg Asp Arg Arg Arg Ala Val Leu Leu Asp Leu Gly Phe Ser 
            100                 105                 110         


Gly Leu Trp Ser Phe Leu Trp Phe Val Gly Phe Cys Phe Leu Thr Asn 
        115                 120                 125             


Gln Trp Gln Arg Thr Ala Pro Gly Pro Ala Thr Thr Gln Ala Gly Asp 
    130                 135                 140                 


Ala Ala Arg Ala Ala Ile Ala Phe Ser Phe Phe Ser Ile Leu Ser Trp 
145                 150                 155                 160 


Val Ala Leu Thr Val Lys Ala Leu Gln Arg Phe Arg Leu Gly Thr Asp 
                165                 170                 175     


Met Ser Leu Phe Ala Thr Glu Gln Leu Ser Thr Gly Ala Ser Gln Ala 
            180                 185                 190         


Tyr Pro Gly Tyr Pro Val Gly Ser Gly Val Glu Gly Thr Glu Thr Tyr 
        195                 200                 205             


Gln Ser Pro Pro Phe Thr Glu Thr Leu Asp Thr Ser Pro Lys Gly Tyr 
    210                 215                 220                 


Gln Val Pro Ala Tyr 
225                 


<210>  2990
<211>  797
<212>  PRT
<213>  Homo sapiens

<400>  2990

Met Asp Cys Ser Ala Pro Lys Glu Met Asn Lys Leu Pro Ala Asn Ser 
1               5                   10                  15      


Pro Glu Ala Ala Ala Ala Gln Gly His Pro Asp Gly Pro Cys Ala Pro 
            20                  25                  30          


Arg Thr Ser Pro Glu Gln Glu Leu Pro Ala Ala Ala Ala Pro Pro Pro 
        35                  40                  45              


Pro Arg Val Pro Arg Ser Ala Ser Thr Gly Ala Gln Thr Phe Gln Ser 
    50                  55                  60                  


Ala Asp Ala Arg Ala Cys Glu Ala Glu Arg Pro Gly Val Gly Ser Cys 
65                  70                  75                  80  


Lys Leu Ser Ser Pro Arg Ala Gln Ala Ala Ser Ala Ala Leu Arg Asp 
                85                  90                  95      


Leu Arg Glu Ala Gln Gly Ala Gln Ala Ser Pro Pro Pro Gly Ser Ser 
            100                 105                 110         


Gly Pro Gly Asn Ala Leu His Cys Lys Ile Pro Phe Leu Arg Gly Pro 
        115                 120                 125             


Glu Gly Asp Ala Asn Val Ser Val Gly Lys Gly Thr Leu Glu Arg Asn 
    130                 135                 140                 


Asn Thr Pro Val Val Gly Trp Val Asn Met Ser Gln Ser Thr Val Val 
145                 150                 155                 160 


Leu Gly Thr Asp Gly Ile Thr Ser Val Leu Pro Gly Ser Val Ala Thr 
                165                 170                 175     


Val Ala Thr Gln Glu Asp Glu Gln Gly Asp Glu Asn Lys Ala Arg Gly 
            180                 185                 190         


Asn Trp Ser Ser Lys Leu Asp Phe Ile Leu Ser Met Val Gly Tyr Ala 
        195                 200                 205             


Val Gly Leu Gly Asn Val Trp Arg Phe Pro Tyr Leu Ala Phe Gln Asn 
    210                 215                 220                 


Gly Gly Gly Ala Phe Leu Ile Pro Tyr Leu Met Met Leu Ala Leu Ala 
225                 230                 235                 240 


Gly Leu Pro Ile Phe Phe Leu Glu Val Ser Leu Gly Gln Phe Ala Ser 
                245                 250                 255     


Gln Gly Pro Val Ser Val Trp Lys Ala Ile Pro Ala Leu Gln Gly Cys 
            260                 265                 270         


Gly Ile Ala Met Leu Ile Ile Ser Val Leu Ile Ala Ile Tyr Tyr Asn 
        275                 280                 285             


Val Ile Ile Cys Tyr Thr Leu Phe Tyr Leu Phe Ala Ser Phe Val Ser 
    290                 295                 300                 


Val Leu Pro Trp Gly Ser Cys Asn Asn Pro Trp Asn Thr Pro Glu Cys 
305                 310                 315                 320 


Lys Asp Lys Thr Lys Leu Leu Leu Asp Ser Cys Val Ile Ser Asp His 
                325                 330                 335     


Pro Lys Ile Gln Ile Lys Asn Ser Thr Phe Cys Met Thr Ala Tyr Pro 
            340                 345                 350         


Asn Val Thr Met Val Asn Phe Thr Ser Gln Ala Asn Lys Thr Phe Val 
        355                 360                 365             


Ser Gly Ser Glu Glu Tyr Phe Lys Tyr Phe Val Leu Lys Ile Ser Ala 
    370                 375                 380                 


Gly Ile Glu Tyr Pro Gly Glu Ile Arg Trp Pro Leu Ala Leu Cys Leu 
385                 390                 395                 400 


Phe Leu Ala Trp Val Ile Val Tyr Ala Ser Leu Ala Lys Gly Ile Lys 
                405                 410                 415     


Thr Ser Gly Lys Val Val Tyr Phe Thr Ala Thr Phe Pro Tyr Val Val 
            420                 425                 430         


Leu Val Ile Leu Leu Ile Arg Gly Val Thr Leu Pro Gly Ala Gly Ala 
        435                 440                 445             


Gly Ile Trp Tyr Phe Ile Thr Pro Lys Trp Glu Lys Leu Thr Asp Ala 
    450                 455                 460                 


Thr Val Trp Lys Asp Ala Ala Thr Gln Ile Phe Phe Ser Leu Ser Ala 
465                 470                 475                 480 


Ala Trp Gly Gly Leu Ile Thr Leu Ser Ser Tyr Asn Lys Phe His Asn 
                485                 490                 495     


Asn Cys Tyr Arg Asp Thr Leu Ile Val Thr Cys Thr Asn Ser Ala Thr 
            500                 505                 510         


Ser Ile Phe Ala Gly Phe Val Ile Phe Ser Val Ile Gly Phe Met Ala 
        515                 520                 525             


Asn Glu Arg Lys Val Asn Ile Glu Asn Val Ala Asp Gln Gly Pro Gly 
    530                 535                 540                 


Ile Ala Phe Val Val Tyr Pro Glu Ala Leu Thr Arg Leu Pro Leu Ser 
545                 550                 555                 560 


Pro Phe Trp Ala Ile Ile Phe Phe Leu Met Leu Leu Thr Leu Gly Leu 
                565                 570                 575     


Asp Thr Met Phe Ala Thr Ile Glu Thr Ile Val Thr Ser Ile Ser Asp 
            580                 585                 590         


Glu Phe Pro Lys Tyr Leu Arg Thr His Lys Pro Val Phe Thr Leu Gly 
        595                 600                 605             


Cys Cys Ile Cys Phe Phe Ile Met Gly Phe Pro Met Ile Thr Gln Gly 
    610                 615                 620                 


Gly Ile Tyr Met Phe Gln Leu Val Asp Thr Tyr Ala Ala Ser Tyr Ala 
625                 630                 635                 640 


Leu Val Ile Ile Ala Ile Phe Glu Leu Val Gly Ile Ser Tyr Val Tyr 
                645                 650                 655     


Gly Leu Gln Arg Phe Cys Glu Asp Ile Glu Met Met Ile Gly Phe Gln 
            660                 665                 670         


Pro Asn Ile Phe Trp Lys Val Cys Trp Ala Phe Val Thr Pro Thr Ile 
        675                 680                 685             


Leu Thr Phe Ile Leu Cys Phe Ser Phe Tyr Gln Trp Glu Pro Met Thr 
    690                 695                 700                 


Tyr Gly Ser Tyr Arg Tyr Pro Asn Trp Ser Met Val Leu Gly Trp Leu 
705                 710                 715                 720 


Met Leu Ala Cys Ser Val Ile Trp Ile Pro Ile Met Phe Val Ile Lys 
                725                 730                 735     


Met His Leu Ala Pro Gly Arg Phe Ile Glu Arg Leu Lys Leu Val Cys 
            740                 745                 750         


Ser Pro Gln Pro Asp Trp Gly Pro Phe Leu Ala Gln His Arg Gly Glu 
        755                 760                 765             


Arg Tyr Lys Asn Met Ile Asp Pro Leu Gly Thr Ser Ser Leu Gly Leu 
    770                 775                 780                 


Lys Leu Pro Val Lys Asp Leu Glu Leu Gly Thr Gln Cys 
785                 790                 795         


<210>  2991
<211>  658
<212>  PRT
<213>  Homo sapiens

<400>  2991

Met Glu Lys Ala Ser Gly Arg Gln Ser Ile Ala Leu Ser Thr Val Glu 
1               5                   10                  15      


Thr Gly Thr Val Asn Pro Gly Leu Glu Leu Met Glu Lys Glu Val Glu 
            20                  25                  30          


Pro Glu Gly Ser Lys Arg Thr Asp Ala Gln Gly His Ser Leu Gly Asp 
        35                  40                  45              


Gly Leu Gly Pro Ser Thr Tyr Gln Arg Arg Ser Arg Trp Pro Phe Ser 
    50                  55                  60                  


Lys Ala Arg Ser Phe Cys Lys Thr His Ala Ser Leu Phe Lys Lys Ile 
65                  70                  75                  80  


Leu Leu Gly Leu Leu Cys Leu Ala Tyr Ala Ala Tyr Leu Leu Ala Ala 
                85                  90                  95      


Cys Ile Leu Asn Phe Gln Arg Ala Leu Ala Leu Phe Val Ile Thr Cys 
            100                 105                 110         


Leu Val Ile Phe Val Leu Val His Ser Phe Leu Lys Lys Leu Leu Gly 
        115                 120                 125             


Lys Lys Leu Thr Arg Cys Leu Lys Pro Phe Glu Asn Ser Arg Leu Arg 
    130                 135                 140                 


Leu Trp Thr Lys Trp Val Phe Ala Gly Val Ser Leu Val Gly Leu Ile 
145                 150                 155                 160 


Leu Trp Leu Ala Leu Asp Thr Ala Gln Arg Pro Glu Gln Leu Ile Pro 
                165                 170                 175     


Phe Ala Gly Ile Cys Met Phe Ile Leu Ile Leu Phe Ala Cys Ser Lys 
            180                 185                 190         


His His Ser Ala Val Ser Trp Arg Thr Val Phe Ser Gly Leu Gly Leu 
        195                 200                 205             


Gln Phe Val Phe Gly Ile Leu Val Ile Arg Thr Asp Leu Gly Tyr Thr 
    210                 215                 220                 


Val Phe Gln Trp Leu Gly Glu Gln Val Gln Ile Phe Leu Asn Tyr Thr 
225                 230                 235                 240 


Val Ala Gly Ser Ser Phe Val Phe Gly Asp Thr Leu Val Lys Asp Val 
                245                 250                 255     


Phe Ala Phe Gln Ala Leu Pro Ile Ile Ile Phe Phe Gly Cys Val Val 
            260                 265                 270         


Ser Ile Leu Tyr Tyr Leu Gly Leu Val Gln Trp Val Val Gln Lys Val 
        275                 280                 285             


Ala Trp Phe Leu Gln Ile Thr Met Gly Thr Thr Ala Thr Glu Thr Leu 
    290                 295                 300                 


Ala Val Ala Gly Asn Ile Phe Val Gly Met Thr Glu Ala Pro Leu Leu 
305                 310                 315                 320 


Ile Arg Pro Tyr Leu Gly Asp Met Thr Leu Ser Glu Ile His Ala Val 
                325                 330                 335     


Met Thr Gly Gly Phe Ala Thr Ile Ser Gly Thr Val Leu Gly Ala Phe 
            340                 345                 350         


Ile Ala Phe Gly Val Asp Ala Ser Ser Leu Ile Ser Ala Ser Val Met 
        355                 360                 365             


Ala Ala Pro Cys Ala Leu Ala Ser Ser Lys Leu Ala Tyr Pro Glu Val 
    370                 375                 380                 


Glu Glu Ser Lys Phe Lys Ser Glu Glu Gly Val Lys Leu Pro Arg Gly 
385                 390                 395                 400 


Lys Glu Arg Asn Val Leu Glu Ala Ala Ser Asn Gly Ala Val Asp Ala 
                405                 410                 415     


Ile Gly Leu Ala Thr Asn Val Ala Ala Asn Leu Ile Ala Phe Leu Ala 
            420                 425                 430         


Val Leu Ala Phe Ile Asn Ala Ala Leu Ser Trp Leu Gly Glu Leu Val 
        435                 440                 445             


Asp Ile Gln Gly Leu Thr Phe Gln Val Ile Cys Ser Tyr Leu Leu Arg 
    450                 455                 460                 


Pro Met Val Phe Met Met Gly Val Glu Trp Thr Asp Cys Pro Met Val 
465                 470                 475                 480 


Ala Glu Met Val Gly Ile Lys Phe Phe Ile Asn Glu Phe Val Ala Tyr 
                485                 490                 495     


Gln Gln Leu Ser Gln Tyr Lys Asn Lys Arg Leu Ser Gly Met Glu Glu 
            500                 505                 510         


Trp Ile Glu Gly Glu Lys Gln Trp Ile Ser Val Arg Ala Glu Ile Ile 
        515                 520                 525             


Thr Thr Phe Ser Leu Cys Gly Phe Ala Asn Leu Ser Ser Ile Gly Ile 
    530                 535                 540                 


Thr Leu Gly Gly Leu Thr Ser Ile Val Pro His Arg Lys Ser Asp Leu 
545                 550                 555                 560 


Ser Lys Val Val Val Arg Ala Leu Phe Thr Gly Ala Cys Val Ser Leu 
                565                 570                 575     


Ile Ser Ala Cys Met Ala Gly Ile Leu Tyr Val Pro Arg Gly Ala Glu 
            580                 585                 590         


Ala Asp Cys Val Ser Phe Pro Asn Thr Ser Phe Thr Asn Arg Thr Tyr 
        595                 600                 605             


Glu Thr Tyr Met Cys Cys Arg Gly Leu Phe Gln Ser Thr Ser Leu Asn 
    610                 615                 620                 


Gly Thr Asn Pro Pro Ser Phe Ser Gly Pro Trp Glu Asp Lys Glu Phe 
625                 630                 635                 640 


Ser Ala Met Ala Leu Thr Asn Cys Cys Gly Phe Tyr Asn Asn Thr Val 
                645                 650                 655     


Cys Ala 
        


<210>  2992
<211>  649
<212>  PRT
<213>  Homo sapiens

<400>  2992

Met Glu Asn Asp Pro Ser Arg Arg Arg Glu Ser Ile Ser Leu Thr Pro 
1               5                   10                  15      


Val Ala Lys Gly Leu Glu Asn Met Gly Ala Asp Phe Leu Glu Ser Leu 
            20                  25                  30          


Glu Glu Gly Gln Leu Pro Arg Ser Asp Leu Ser Pro Ala Glu Ile Arg 
        35                  40                  45              


Ser Ser Trp Ser Glu Ala Ala Pro Lys Pro Phe Ser Arg Trp Arg Asn 
    50                  55                  60                  


Leu Gln Pro Ala Leu Arg Ala Arg Ser Phe Cys Arg Glu His Met Gln 
65                  70                  75                  80  


Leu Phe Arg Trp Ile Gly Thr Gly Leu Leu Cys Thr Gly Leu Ser Ala 
                85                  90                  95      


Phe Leu Leu Val Ala Cys Leu Leu Asp Phe Gln Arg Ala Leu Ala Leu 
            100                 105                 110         


Phe Val Leu Thr Cys Val Val Leu Thr Phe Leu Gly His Arg Leu Leu 
        115                 120                 125             


Lys Arg Leu Leu Gly Pro Lys Leu Arg Arg Phe Leu Lys Pro Gln Gly 
    130                 135                 140                 


His Pro Arg Leu Leu Leu Trp Phe Lys Arg Gly Leu Ala Leu Ala Ala 
145                 150                 155                 160 


Phe Leu Gly Leu Val Leu Trp Leu Ser Leu Asp Thr Ser Gln Arg Pro 
                165                 170                 175     


Glu Gln Leu Val Ser Phe Ala Gly Ile Cys Val Phe Val Ala Leu Leu 
            180                 185                 190         


Phe Ala Cys Ser Lys His His Cys Ala Val Ser Trp Arg Ala Val Ser 
        195                 200                 205             


Trp Gly Leu Gly Leu Gln Phe Val Leu Gly Leu Leu Val Ile Arg Thr 
    210                 215                 220                 


Glu Pro Gly Phe Ile Ala Phe Glu Trp Leu Gly Glu Gln Ile Arg Ile 
225                 230                 235                 240 


Phe Leu Ser Tyr Thr Lys Ala Gly Ser Ser Phe Val Phe Gly Glu Ala 
                245                 250                 255     


Leu Val Lys Asp Val Phe Ala Phe Gln Val Leu Pro Ile Ile Val Phe 
            260                 265                 270         


Phe Ser Cys Val Ile Ser Val Leu Tyr His Val Gly Leu Met Gln Trp 
        275                 280                 285             


Val Ile Leu Lys Ile Ala Trp Leu Met Gln Val Thr Met Gly Thr Thr 
    290                 295                 300                 


Ala Thr Glu Thr Leu Ser Val Ala Gly Asn Ile Phe Val Ser Gln Thr 
305                 310                 315                 320 


Glu Ala Pro Leu Leu Ile Arg Pro Tyr Leu Ala Asp Met Thr Leu Ser 
                325                 330                 335     


Glu Val His Val Val Met Thr Gly Gly Tyr Ala Thr Ile Ala Gly Ser 
            340                 345                 350         


Leu Leu Gly Ala Tyr Ile Ser Phe Gly Ile Asp Ala Thr Ser Leu Ile 
        355                 360                 365             


Ala Ala Ser Val Met Ala Ala Pro Cys Ala Leu Ala Leu Ser Lys Leu 
    370                 375                 380                 


Val Tyr Pro Glu Val Glu Glu Ser Lys Phe Arg Arg Glu Glu Gly Val 
385                 390                 395                 400 


Lys Leu Thr Tyr Gly Asp Ala Gln Asn Leu Ile Glu Ala Ala Ser Thr 
                405                 410                 415     


Gly Ala Ala Ile Ser Val Lys Val Val Ala Asn Ile Ala Ala Asn Leu 
            420                 425                 430         


Ile Ala Phe Leu Ala Val Leu Asp Phe Ile Asn Ala Ala Leu Ser Trp 
        435                 440                 445             


Leu Gly Asp Met Val Asp Ile Gln Gly Leu Ser Phe Gln Leu Ile Cys 
    450                 455                 460                 


Ser Tyr Ile Leu Arg Pro Val Ala Phe Leu Met Gly Val Ala Trp Glu 
465                 470                 475                 480 


Asp Cys Pro Val Val Ala Glu Leu Leu Gly Ile Lys Leu Phe Leu Asn 
                485                 490                 495     


Glu Phe Val Ala Tyr Gln Asp Leu Ser Lys Tyr Lys Gln Arg Arg Leu 
            500                 505                 510         


Ala Gly Ala Glu Glu Trp Val Gly Asp Arg Lys Gln Trp Ile Ser Val 
        515                 520                 525             


Arg Ala Glu Val Leu Thr Thr Phe Ala Leu Cys Gly Phe Ala Asn Phe 
    530                 535                 540                 


Ser Ser Ile Gly Ile Met Leu Gly Gly Leu Thr Ser Met Val Pro Gln 
545                 550                 555                 560 


Arg Lys Ser Asp Phe Ser Gln Ile Val Leu Arg Ala Leu Phe Thr Gly 
                565                 570                 575     


Ala Cys Val Ser Leu Val Asn Ala Cys Met Ala Gly Ile Leu Tyr Met 
            580                 585                 590         


Pro Arg Gly Ala Glu Val Asp Cys Met Ser Leu Leu Asn Thr Thr Leu 
        595                 600                 605             


Ser Ser Ser Ser Phe Glu Ile Tyr Gln Cys Cys Arg Glu Ala Phe Gln 
    610                 615                 620                 


Ser Val Asn Pro Glu Phe Ser Pro Glu Ala Leu Asp Asn Cys Cys Arg 
625                 630                 635                 640 


Phe Tyr Asn His Thr Ile Cys Ala Gln 
                645                 


<210>  2993
<211>  617
<212>  PRT
<213>  Homo sapiens

<400>  2993

Met Gly Pro Thr Leu Ala Val Pro Thr Pro Tyr Gly Cys Ile Gly Cys 
1               5                   10                  15      


Lys Leu Pro Gln Pro Glu Tyr Pro Pro Ala Leu Ile Ile Phe Met Phe 
            20                  25                  30          


Cys Ala Met Val Ile Thr Ile Val Val Asp Leu Ile Gly Asn Ser Met 
        35                  40                  45              


Val Ile Leu Ala Val Thr Lys Asn Lys Lys Leu Arg Asn Ser Gly Asn 
    50                  55                  60                  


Ile Phe Val Val Ser Leu Ser Val Ala Asp Met Leu Val Ala Ile Tyr 
65                  70                  75                  80  


Pro Tyr Pro Leu Met Leu His Ala Met Ser Ile Gly Gly Trp Asp Leu 
                85                  90                  95      


Ser Gln Leu Gln Cys Gln Met Val Gly Phe Ile Thr Gly Leu Ser Val 
            100                 105                 110         


Val Gly Ser Ile Phe Asn Ile Val Ala Ile Ala Ile Asn Arg Tyr Cys 
        115                 120                 125             


Tyr Ile Cys His Ser Leu Gln Tyr Glu Arg Ile Phe Ser Val Arg Asn 
    130                 135                 140                 


Thr Cys Ile Tyr Leu Val Ile Thr Trp Ile Met Thr Val Leu Ala Val 
145                 150                 155                 160 


Leu Pro Asn Met Tyr Ile Gly Thr Ile Glu Tyr Asp Pro Arg Thr Tyr 
                165                 170                 175     


Thr Cys Ile Phe Asn Tyr Leu Asn Asn Pro Val Phe Thr Val Thr Ile 
            180                 185                 190         


Val Cys Ile His Phe Val Leu Pro Leu Leu Ile Val Gly Phe Cys Tyr 
        195                 200                 205             


Val Arg Ile Trp Thr Lys Val Leu Ala Ala Arg Asp Pro Ala Gly Gln 
    210                 215                 220                 


Asn Pro Asp Asn Gln Leu Ala Glu Val Arg Asn Phe Leu Thr Met Phe 
225                 230                 235                 240 


Val Ile Phe Leu Leu Phe Ala Val Cys Trp Cys Pro Ile Asn Val Leu 
                245                 250                 255     


Thr Val Leu Val Ala Val Ser Pro Lys Glu Met Ala Gly Lys Ile Pro 
            260                 265                 270         


Asn Trp Leu Tyr Leu Ala Ala Tyr Phe Ile Ala Tyr Phe Asn Ser Cys 
        275                 280                 285             


Leu Asn Ala Val Ile Tyr Gly Leu Leu Asn Glu Asn Phe Arg Arg Glu 
    290                 295                 300                 


Tyr Trp Thr Ile Phe His Ala Met Arg His Pro Ile Ile Phe Phe Ser 
305                 310                 315                 320 


Gly Leu Ile Ser Asp Ile Arg Glu Met Gln Glu Ala Arg Thr Leu Ala 
                325                 330                 335     


Arg Ala Arg Ala His Ala Arg Asp Gln Ala Arg Glu Gln Asp Arg Ala 
            340                 345                 350         


His Ala Cys Pro Ala Val Glu Glu Thr Pro Met Asn Val Arg Asn Val 
        355                 360                 365             


Pro Leu Pro Gly Asp Ala Ala Ala Gly His Pro Asp Arg Ala Ser Gly 
    370                 375                 380                 


His Pro Lys Pro His Ser Arg Ser Ser Ser Ala Tyr Arg Lys Ser Ala 
385                 390                 395                 400 


Ser Thr His His Lys Ser Val Phe Ser His Ser Lys Ala Ala Ser Gly 
                405                 410                 415     


His Leu Lys Pro Val Ser Gly His Ser Lys Pro Ala Ser Gly His Pro 
            420                 425                 430         


Lys Ser Ala Thr Val Tyr Pro Lys Pro Ala Ser Val His Phe Lys Ala 
        435                 440                 445             


Asp Ser Val His Phe Lys Gly Asp Ser Val His Phe Lys Pro Asp Ser 
    450                 455                 460                 


Val His Phe Lys Pro Ala Ser Ser Asn Pro Lys Pro Ile Thr Gly His 
465                 470                 475                 480 


His Val Ser Ala Gly Ser His Ser Lys Ser Ala Phe Ser Ala Ala Thr 
                485                 490                 495     


Ser His Pro Lys Pro Thr Thr Gly His Ile Lys Pro Ala Thr Ser His 
            500                 505                 510         


Ala Glu Pro Thr Thr Ala Asp Tyr Pro Lys Pro Ala Thr Thr Ser His 
        515                 520                 525             


Pro Lys Pro Thr Ala Ala Asp Asn Pro Glu Leu Ser Ala Ser His Cys 
    530                 535                 540                 


Pro Glu Ile Pro Ala Ile Ala His Pro Val Ser Asp Asp Ser Asp Leu 
545                 550                 555                 560 


Pro Glu Ser Ala Ser Ser Pro Ala Ala Gly Pro Thr Lys Pro Ala Ala 
                565                 570                 575     


Ser Gln Leu Glu Ser Asp Thr Ile Ala Asp Leu Pro Asp Pro Thr Val 
            580                 585                 590         


Val Thr Thr Ser Thr Asn Asp Tyr His Asp Val Val Val Ile Asp Val 
        595                 600                 605             


Glu Asp Asp Pro Asp Glu Met Ala Val 
    610                 615         


<210>  2994
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  2994

Met Gly Ser Leu Tyr Ser Glu Tyr Leu Asn Pro Asn Lys Val Gln Glu 
1               5                   10                  15      


His Tyr Asn Tyr Thr Lys Glu Thr Leu Glu Thr Gln Glu Thr Thr Ser 
            20                  25                  30          


Arg Gln Val Ala Ser Ala Phe Ile Val Ile Leu Cys Cys Ala Ile Val 
        35                  40                  45              


Val Glu Asn Leu Leu Val Leu Ile Ala Val Ala Arg Asn Ser Lys Phe 
    50                  55                  60                  


His Ser Ala Met Tyr Leu Phe Leu Gly Asn Leu Ala Ala Ser Asp Leu 
65                  70                  75                  80  


Leu Ala Gly Val Ala Phe Val Ala Asn Thr Leu Leu Ser Gly Ser Val 
                85                  90                  95      


Thr Leu Arg Leu Thr Pro Val Gln Trp Phe Ala Arg Glu Gly Ser Ala 
            100                 105                 110         


Phe Ile Thr Leu Ser Ala Ser Val Phe Ser Leu Leu Ala Ile Ala Ile 
        115                 120                 125             


Glu Arg His Val Ala Ile Ala Lys Val Lys Leu Tyr Gly Ser Asp Lys 
    130                 135                 140                 


Ser Cys Arg Met Leu Leu Leu Ile Gly Ala Ser Trp Leu Ile Ser Leu 
145                 150                 155                 160 


Val Leu Gly Gly Leu Pro Ile Leu Gly Trp Asn Cys Leu Gly His Leu 
                165                 170                 175     


Glu Ala Cys Ser Thr Val Leu Pro Leu Tyr Ala Lys His Tyr Val Leu 
            180                 185                 190         


Cys Val Val Thr Ile Phe Ser Ile Ile Leu Leu Ala Ile Val Ala Leu 
        195                 200                 205             


Tyr Val Arg Ile Tyr Cys Val Val Arg Ser Ser His Ala Asp Met Ala 
    210                 215                 220                 


Ala Pro Gln Thr Leu Ala Leu Leu Lys Thr Val Thr Ile Val Leu Gly 
225                 230                 235                 240 


Val Phe Ile Val Cys Trp Leu Pro Ala Phe Ser Ile Leu Leu Leu Asp 
                245                 250                 255     


Tyr Ala Cys Pro Val His Ser Cys Pro Ile Leu Tyr Lys Ala His Tyr 
            260                 265                 270         


Phe Phe Ala Val Ser Thr Leu Asn Ser Leu Leu Asn Pro Val Ile Tyr 
        275                 280                 285             


Thr Trp Arg Ser Arg Asp Leu Arg Arg Glu Val Leu Arg Pro Leu Gln 
    290                 295                 300                 


Cys Trp Arg Pro Gly Val Gly Val Gln Gly Arg Arg Arg Gly Gly Thr 
305                 310                 315                 320 


Pro Gly His His Leu Leu Pro Leu Arg Ser Ser Ser Ser Leu Glu Arg 
                325                 330                 335     


Gly Met His Met Pro Thr Ser Pro Thr Phe Leu Glu Gly Asn Thr Val 
            340                 345                 350         


Val 
    


<210>  2995
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  2995

Met Ser Arg Gly Leu Gln Leu Leu Leu Leu Ser Cys Ala Tyr Ser Leu 
1               5                   10                  15      


Ala Pro Ala Thr Pro Glu Val Lys Val Ala Cys Ser Glu Asp Val Asp 
            20                  25                  30          


Leu Pro Cys Thr Ala Pro Trp Asp Pro Gln Val Pro Tyr Thr Val Ser 
        35                  40                  45              


Trp Val Lys Leu Leu Glu Gly Gly Glu Glu Arg Met Glu Thr Pro Gln 
    50                  55                  60                  


Glu Asp His Leu Arg Gly Gln His Tyr His Gln Lys Gly Gln Asn Gly 
65                  70                  75                  80  


Ser Phe Asp Ala Pro Asn Glu Arg Pro Tyr Ser Leu Lys Ile Arg Asn 
                85                  90                  95      


Thr Thr Ser Cys Asn Ser Gly Thr Tyr Arg Cys Thr Leu Gln Asp Pro 
            100                 105                 110         


Asp Gly Gln Arg Asn Leu Ser Gly Lys Val Ile Leu Arg Val Thr Gly 
        115                 120                 125             


Cys Pro Ala Gln Arg Lys Glu Glu Thr Phe Lys Lys Tyr Arg Ala Glu 
    130                 135                 140                 


Ile Val Leu Leu Leu Ala Leu Val Ile Phe Tyr Leu Thr Leu Ile Ile 
145                 150                 155                 160 


Phe Thr Cys Lys Phe Ala Arg Leu Gln Ser Ile Phe Pro Asp Phe Ser 
                165                 170                 175     


Lys Ala Gly Met Glu Arg Ala Phe Leu Pro Val Thr Ser Pro Asn Lys 
            180                 185                 190         


His Leu Gly Leu Val Thr Pro His Lys Thr Glu Leu Val 
        195                 200                 205 


<210>  2996
<211>  1156
<212>  PRT
<213>  Homo sapiens

<400>  2996

Met Ser Lys Leu Arg Met Val Leu Leu Glu Asp Ser Gly Ser Ala Asp 
1               5                   10                  15      


Phe Arg Arg His Phe Val Asn Leu Ser Pro Phe Thr Ile Thr Val Val 
            20                  25                  30          


Leu Leu Leu Ser Ala Cys Phe Val Thr Ser Ser Leu Gly Gly Thr Asp 
        35                  40                  45              


Lys Glu Leu Arg Leu Val Asp Gly Glu Asn Lys Cys Ser Gly Arg Val 
    50                  55                  60                  


Glu Val Lys Val Gln Glu Glu Trp Gly Thr Val Cys Asn Asn Gly Trp 
65                  70                  75                  80  


Ser Met Glu Ala Val Ser Val Ile Cys Asn Gln Leu Gly Cys Pro Thr 
                85                  90                  95      


Ala Ile Lys Ala Pro Gly Trp Ala Asn Ser Ser Ala Gly Ser Gly Arg 
            100                 105                 110         


Ile Trp Met Asp His Val Ser Cys Arg Gly Asn Glu Ser Ala Leu Trp 
        115                 120                 125             


Asp Cys Lys His Asp Gly Trp Gly Lys His Ser Asn Cys Thr His Gln 
    130                 135                 140                 


Gln Asp Ala Gly Val Thr Cys Ser Asp Gly Ser Asn Leu Glu Met Arg 
145                 150                 155                 160 


Leu Thr Arg Gly Gly Asn Met Cys Ser Gly Arg Ile Glu Ile Lys Phe 
                165                 170                 175     


Gln Gly Arg Trp Gly Thr Val Cys Asp Asp Asn Phe Asn Ile Asp His 
            180                 185                 190         


Ala Ser Val Ile Cys Arg Gln Leu Glu Cys Gly Ser Ala Val Ser Phe 
        195                 200                 205             


Ser Gly Ser Ser Asn Phe Gly Glu Gly Ser Gly Pro Ile Trp Phe Asp 
    210                 215                 220                 


Asp Leu Ile Cys Asn Gly Asn Glu Ser Ala Leu Trp Asn Cys Lys His 
225                 230                 235                 240 


Gln Gly Trp Gly Lys His Asn Cys Asp His Ala Glu Asp Ala Gly Val 
                245                 250                 255     


Ile Cys Ser Lys Gly Ala Asp Leu Ser Leu Arg Leu Val Asp Gly Val 
            260                 265                 270         


Thr Glu Cys Ser Gly Arg Leu Glu Val Arg Phe Gln Gly Glu Trp Gly 
        275                 280                 285             


Thr Ile Cys Asp Asp Gly Trp Asp Ser Tyr Asp Ala Ala Val Ala Cys 
    290                 295                 300                 


Lys Gln Leu Gly Cys Pro Thr Ala Val Thr Ala Ile Gly Arg Val Asn 
305                 310                 315                 320 


Ala Ser Lys Gly Phe Gly His Ile Trp Leu Asp Ser Val Ser Cys Gln 
                325                 330                 335     


Gly His Glu Pro Ala Ile Trp Gln Cys Lys His His Glu Trp Gly Lys 
            340                 345                 350         


His Tyr Cys Asn His Asn Glu Asp Ala Gly Val Thr Cys Ser Asp Gly 
        355                 360                 365             


Ser Asp Leu Glu Leu Arg Leu Arg Gly Gly Gly Ser Arg Cys Ala Gly 
    370                 375                 380                 


Thr Val Glu Val Glu Ile Gln Arg Leu Leu Gly Lys Val Cys Asp Arg 
385                 390                 395                 400 


Gly Trp Gly Leu Lys Glu Ala Asp Val Val Cys Arg Gln Leu Gly Cys 
                405                 410                 415     


Gly Ser Ala Leu Lys Thr Ser Tyr Gln Val Tyr Ser Lys Ile Gln Ala 
            420                 425                 430         


Thr Asn Thr Trp Leu Phe Leu Ser Ser Cys Asn Gly Asn Glu Thr Ser 
        435                 440                 445             


Leu Trp Asp Cys Lys Asn Trp Gln Trp Gly Gly Leu Thr Cys Asp His 
    450                 455                 460                 


Tyr Glu Glu Ala Lys Ile Thr Cys Ser Ala His Arg Glu Pro Arg Leu 
465                 470                 475                 480 


Val Gly Gly Asp Ile Pro Cys Ser Gly Arg Val Glu Val Lys His Gly 
                485                 490                 495     


Asp Thr Trp Gly Ser Ile Cys Asp Ser Asp Phe Ser Leu Glu Ala Ala 
            500                 505                 510         


Ser Val Leu Cys Arg Glu Leu Gln Cys Gly Thr Val Val Ser Ile Leu 
        515                 520                 525             


Gly Gly Ala His Phe Gly Glu Gly Asn Gly Gln Ile Trp Ala Glu Glu 
    530                 535                 540                 


Phe Gln Cys Glu Gly His Glu Ser His Leu Ser Leu Cys Pro Val Ala 
545                 550                 555                 560 


Pro Arg Pro Glu Gly Thr Cys Ser His Ser Arg Asp Val Gly Val Val 
                565                 570                 575     


Cys Ser Arg Tyr Thr Glu Ile Arg Leu Val Asn Gly Lys Thr Pro Cys 
            580                 585                 590         


Glu Gly Arg Val Glu Leu Lys Thr Leu Gly Ala Trp Gly Ser Leu Cys 
        595                 600                 605             


Asn Ser His Trp Asp Ile Glu Asp Ala His Val Leu Cys Gln Gln Leu 
    610                 615                 620                 


Lys Cys Gly Val Ala Leu Ser Thr Pro Gly Gly Ala Arg Phe Gly Lys 
625                 630                 635                 640 


Gly Asn Gly Gln Ile Trp Arg His Met Phe His Cys Thr Gly Thr Glu 
                645                 650                 655     


Gln His Met Gly Asp Cys Pro Val Thr Ala Leu Gly Ala Ser Leu Cys 
            660                 665                 670         


Pro Ser Glu Gln Val Ala Ser Val Ile Cys Ser Gly Asn Gln Ser Gln 
        675                 680                 685             


Thr Leu Ser Ser Cys Asn Ser Ser Ser Leu Gly Pro Thr Arg Pro Thr 
    690                 695                 700                 


Ile Pro Glu Glu Ser Ala Val Ala Cys Ile Glu Ser Gly Gln Leu Arg 
705                 710                 715                 720 


Leu Val Asn Gly Gly Gly Arg Cys Ala Gly Arg Val Glu Ile Tyr His 
                725                 730                 735     


Glu Gly Ser Trp Gly Thr Ile Cys Asp Asp Ser Trp Asp Leu Ser Asp 
            740                 745                 750         


Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Glu Ala Ile Asn Ala 
        755                 760                 765             


Thr Gly Ser Ala His Phe Gly Glu Gly Thr Gly Pro Ile Trp Leu Asp 
    770                 775                 780                 


Glu Met Lys Cys Asn Gly Lys Glu Ser Arg Ile Trp Gln Cys His Ser 
785                 790                 795                 800 


His Gly Trp Gly Gln Gln Asn Cys Arg His Lys Glu Asp Ala Gly Val 
                805                 810                 815     


Ile Cys Ser Glu Phe Met Ser Leu Arg Leu Thr Ser Glu Ala Ser Arg 
            820                 825                 830         


Glu Ala Cys Ala Gly Arg Leu Glu Val Phe Tyr Asn Gly Ala Trp Gly 
        835                 840                 845             


Thr Val Gly Lys Ser Ser Met Ser Glu Thr Thr Val Gly Val Val Cys 
    850                 855                 860                 


Arg Gln Leu Gly Cys Ala Asp Lys Gly Lys Ile Asn Pro Ala Ser Leu 
865                 870                 875                 880 


Asp Lys Ala Met Ser Ile Pro Met Trp Val Asp Asn Val Gln Cys Pro 
                885                 890                 895     


Lys Gly Pro Asp Thr Leu Trp Gln Cys Pro Ser Ser Pro Trp Glu Lys 
            900                 905                 910         


Arg Leu Ala Ser Pro Ser Glu Glu Thr Trp Ile Thr Cys Asp Asn Lys 
        915                 920                 925             


Ile Arg Leu Gln Glu Gly Pro Thr Ser Cys Ser Gly Arg Val Glu Ile 
    930                 935                 940                 


Trp His Gly Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Leu 
945                 950                 955                 960 


Asp Asp Ala Gln Val Val Cys Gln Gln Leu Gly Cys Gly Pro Ala Leu 
                965                 970                 975     


Lys Ala Phe Lys Glu Ala Glu Phe Gly Gln Gly Thr Gly Pro Ile Trp 
            980                 985                 990         


Leu Asn Glu Val Lys Cys Lys Gly  Asn Glu Ser Ser Leu  Trp Asp Cys 
        995                 1000                 1005             


Pro Ala  Arg Arg Trp Gly His  Ser Glu Cys Gly His  Lys Glu Asp 
    1010                 1015                 1020             


Ala Ala  Val Asn Cys Thr Asp  Ile Ser Val Gln Lys  Thr Pro Gln 
    1025                 1030                 1035             


Lys Ala  Thr Thr Gly Arg Ser  Ser Arg Gln Ser Ser  Phe Ile Ala 
    1040                 1045                 1050             


Val Gly  Ile Leu Gly Val Val  Leu Leu Ala Ile Phe  Val Ala Leu 
    1055                 1060                 1065             


Phe Phe  Leu Thr Lys Lys Arg  Arg Gln Arg Gln Arg  Leu Ala Val 
    1070                 1075                 1080             


Ser Ser  Arg Gly Glu Asn Leu  Val His Gln Ile Gln  Tyr Arg Glu 
    1085                 1090                 1095             


Met Asn  Ser Cys Leu Asn Ala  Asp Asp Leu Asp Leu  Met Asn Ser 
    1100                 1105                 1110             


Ser Glu  Asn Ser His Glu Ser  Ala Asp Phe Ser Ala  Ala Glu Leu 
    1115                 1120                 1125             


Ile Ser  Val Ser Lys Phe Leu  Pro Ile Ser Gly Met  Glu Lys Glu 
    1130                 1135                 1140             


Ala Ile  Leu Ser His Thr Glu  Lys Glu Asn Gly Asn  Leu 
    1145                 1150                 1155     


<210>  2997
<211>  553
<212>  PRT
<213>  Homo sapiens

<400>  2997

Met Lys Leu Gly Ser Ser Arg Ala Gly Pro Gly Arg Gly Ser Ala Gly 
1               5                   10                  15      


Leu Leu Pro Gly Val His Glu Leu Pro Met Gly Ile Pro Ala Pro Trp 
            20                  25                  30          


Gly Thr Ser Pro Leu Ser Phe His Arg Lys Cys Ser Leu Trp Ala Pro 
        35                  40                  45              


Gly Arg Pro Phe Leu Thr Leu Val Leu Leu Val Ser Ile Lys Gln Val 
    50                  55                  60                  


Thr Gly Ser Leu Leu Glu Glu Thr Thr Arg Lys Trp Ala Gln Tyr Lys 
65                  70                  75                  80  


Gln Ala Cys Leu Arg Asp Leu Leu Lys Glu Pro Ser Gly Ile Phe Cys 
                85                  90                  95      


Asn Gly Thr Phe Asp Gln Tyr Val Cys Trp Pro His Ser Ser Pro Gly 
            100                 105                 110         


Asn Val Ser Val Pro Cys Pro Ser Tyr Leu Pro Trp Trp Ser Glu Glu 
        115                 120                 125             


Ser Ser Gly Arg Ala Tyr Arg His Cys Leu Ala Gln Gly Thr Trp Gln 
    130                 135                 140                 


Thr Ile Glu Asn Ala Thr Asp Ile Trp Gln Asp Asp Ser Glu Cys Ser 
145                 150                 155                 160 


Glu Asn His Ser Phe Lys Gln Asn Val Asp Arg Tyr Ala Leu Leu Ser 
                165                 170                 175     


Thr Leu Gln Leu Met Tyr Thr Val Gly Tyr Ser Phe Ser Leu Ile Ser 
            180                 185                 190         


Leu Phe Leu Ala Leu Thr Leu Leu Leu Phe Leu Arg Lys Leu His Cys 
        195                 200                 205             


Thr Arg Asn Tyr Ile His Met Asn Leu Phe Ala Ser Phe Ile Leu Arg 
    210                 215                 220                 


Thr Leu Ala Val Leu Val Lys Asp Val Val Phe Tyr Asn Ser Tyr Ser 
225                 230                 235                 240 


Lys Arg Pro Asp Asn Glu Asn Gly Trp Met Ser Tyr Leu Ser Glu Met 
                245                 250                 255     


Ser Thr Ser Cys Arg Ser Val Gln Val Leu Leu His Tyr Phe Val Gly 
            260                 265                 270         


Ala Asn Tyr Leu Trp Leu Leu Val Glu Gly Leu Tyr Leu His Thr Leu 
        275                 280                 285             


Leu Glu Pro Thr Val Leu Pro Glu Arg Arg Leu Trp Pro Arg Tyr Leu 
    290                 295                 300                 


Leu Leu Gly Trp Ala Phe Pro Val Leu Phe Val Val Pro Trp Gly Phe 
305                 310                 315                 320 


Ala Arg Ala His Leu Glu Asn Thr Gly Cys Trp Thr Thr Asn Gly Asn 
                325                 330                 335     


Lys Lys Ile Trp Trp Ile Ile Arg Gly Pro Met Met Leu Cys Val Thr 
            340                 345                 350         


Val Asn Phe Phe Ile Phe Leu Lys Ile Leu Lys Leu Leu Ile Ser Lys 
        355                 360                 365             


Leu Lys Ala His Gln Met Cys Phe Arg Asp Tyr Lys Tyr Arg Leu Ala 
    370                 375                 380                 


Lys Ser Thr Leu Val Leu Ile Pro Leu Leu Gly Val His Glu Ile Leu 
385                 390                 395                 400 


Phe Ser Phe Ile Thr Asp Asp Gln Val Glu Gly Phe Ala Lys Leu Ile 
                405                 410                 415     


Arg Leu Phe Ile Gln Leu Thr Leu Ser Ser Phe His Gly Phe Leu Val 
            420                 425                 430         


Ala Leu Gln Tyr Gly Phe Ala Asn Gly Glu Val Lys Ala Glu Leu Arg 
        435                 440                 445             


Lys Tyr Trp Val Arg Phe Leu Leu Ala Arg His Ser Gly Cys Arg Ala 
    450                 455                 460                 


Cys Val Leu Gly Lys Asp Phe Arg Phe Leu Gly Lys Cys Pro Lys Lys 
465                 470                 475                 480 


Leu Ser Glu Gly Asp Gly Ala Glu Lys Leu Arg Lys Leu Gln Pro Ser 
                485                 490                 495     


Leu Asn Ser Gly Arg Leu Leu His Leu Ala Met Arg Gly Leu Gly Glu 
            500                 505                 510         


Leu Gly Ala Gln Pro Gln Gln Asp His Ala Arg Trp Pro Arg Gly Ser 
        515                 520                 525             


Ser Leu Ser Glu Cys Ser Glu Gly Asp Val Thr Met Ala Asn Thr Met 
    530                 535                 540                 


Glu Glu Ile Leu Glu Glu Ser Glu Ile 
545                 550             


<210>  2998
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  2998

Met Ala Ser Ser Thr Thr Arg Gly Pro Arg Val Ser Asp Leu Phe Ser 
1               5                   10                  15      


Gly Leu Pro Pro Ala Val Thr Thr Pro Ala Asn Gln Ser Ala Glu Ala 
            20                  25                  30          


Ser Ala Gly Asn Gly Ser Val Ala Gly Ala Asp Ala Pro Ala Val Thr 
        35                  40                  45              


Pro Phe Gln Ser Leu Gln Leu Val His Gln Leu Lys Gly Leu Ile Val 
    50                  55                  60                  


Leu Leu Tyr Ser Val Val Val Val Val Gly Leu Val Gly Asn Cys Leu 
65                  70                  75                  80  


Leu Val Leu Val Ile Ala Arg Val Arg Arg Leu His Asn Val Thr Asn 
                85                  90                  95      


Phe Leu Ile Gly Asn Leu Ala Leu Ser Asp Val Leu Met Cys Thr Ala 
            100                 105                 110         


Cys Val Pro Leu Thr Leu Ala Tyr Ala Phe Glu Pro Arg Gly Trp Val 
        115                 120                 125             


Phe Gly Gly Gly Leu Cys His Leu Val Phe Phe Leu Gln Pro Val Thr 
    130                 135                 140                 


Val Tyr Val Ser Val Phe Thr Leu Thr Thr Ile Ala Val Asp Arg Tyr 
145                 150                 155                 160 


Val Val Leu Val His Pro Leu Arg Arg Arg Ile Ser Leu Arg Leu Ser 
                165                 170                 175     


Ala Tyr Ala Val Leu Ala Ile Trp Ala Leu Ser Ala Val Leu Ala Leu 
            180                 185                 190         


Pro Ala Ala Val His Thr Tyr His Val Glu Leu Lys Pro His Asp Val 
        195                 200                 205             


Arg Leu Cys Glu Glu Phe Trp Gly Ser Gln Glu Arg Gln Arg Gln Leu 
    210                 215                 220                 


Tyr Ala Trp Gly Leu Leu Leu Val Thr Tyr Leu Leu Pro Leu Leu Val 
225                 230                 235                 240 


Ile Leu Leu Ser Tyr Val Arg Val Ser Val Lys Leu Arg Asn Arg Val 
                245                 250                 255     


Val Pro Gly Cys Val Thr Gln Ser Gln Ala Asp Trp Asp Arg Ala Arg 
            260                 265                 270         


Arg Arg Arg Thr Phe Cys Leu Leu Val Val Val Val Val Val Phe Ala 
        275                 280                 285             


Val Cys Trp Leu Pro Leu His Val Phe Asn Leu Leu Arg Asp Leu Asp 
    290                 295                 300                 


Pro His Ala Ile Asp Pro Tyr Ala Phe Gly Leu Val Gln Leu Leu Cys 
305                 310                 315                 320 


His Trp Leu Ala Met Ser Ser Ala Cys Tyr Asn Pro Phe Ile Tyr Ala 
                325                 330                 335     


Trp Leu His Asp Ser Phe Arg Glu Glu Leu Arg Lys Leu Leu Val Ala 
            340                 345                 350         


Trp Pro Arg Lys Ile Ala Pro His Gly Gln Asn Met Thr Val Ser Val 
        355                 360                 365             


Val Ile 
    370 


<210>  2999
<211>  542
<212>  PRT
<213>  Homo sapiens

<400>  2999

Met Thr Phe Ser Glu Ile Leu Asp Arg Val Gly Ser Met Gly His Phe 
1               5                   10                  15      


Gln Phe Leu His Val Ala Ile Leu Gly Leu Pro Ile Leu Asn Met Ala 
            20                  25                  30          


Asn His Asn Leu Leu Gln Ile Phe Thr Ala Ala Thr Pro Val His His 
        35                  40                  45              


Cys Arg Pro Pro His Asn Ala Ser Thr Gly Pro Trp Val Leu Pro Met 
    50                  55                  60                  


Gly Pro Asn Gly Lys Pro Glu Arg Cys Leu Arg Phe Val His Pro Pro 
65                  70                  75                  80  


Asn Ala Ser Leu Pro Asn Asp Thr Gln Arg Ala Met Glu Pro Cys Leu 
                85                  90                  95      


Asp Gly Trp Val Tyr Asn Ser Thr Lys Asp Ser Ile Val Thr Glu Trp 
            100                 105                 110         


Asp Leu Val Cys Asn Ser Asn Lys Leu Lys Glu Met Ala Gln Ser Ile 
        115                 120                 125             


Phe Met Ala Gly Ile Leu Ile Gly Gly Leu Val Leu Gly Asp Leu Ser 
    130                 135                 140                 


Asp Arg Phe Gly Arg Arg Pro Ile Leu Thr Cys Ser Tyr Leu Leu Leu 
145                 150                 155                 160 


Ala Ala Ser Gly Ser Gly Ala Ala Phe Ser Pro Thr Phe Pro Ile Tyr 
                165                 170                 175     


Met Val Phe Arg Phe Leu Cys Gly Phe Gly Ile Ser Gly Ile Thr Leu 
            180                 185                 190         


Ser Thr Val Ile Leu Asn Val Glu Trp Val Pro Thr Arg Met Arg Ala 
        195                 200                 205             


Ile Met Ser Thr Ala Leu Gly Tyr Cys Tyr Thr Phe Gly Gln Phe Ile 
    210                 215                 220                 


Leu Pro Gly Leu Ala Tyr Ala Ile Pro Gln Trp Arg Trp Leu Gln Leu 
225                 230                 235                 240 


Thr Val Ser Ile Pro Phe Phe Val Phe Phe Leu Ser Ser Trp Trp Thr 
                245                 250                 255     


Pro Glu Ser Ile Arg Trp Leu Val Leu Ser Gly Lys Ser Ser Lys Ala 
            260                 265                 270         


Leu Lys Ile Leu Arg Arg Val Ala Val Phe Asn Gly Lys Lys Glu Glu 
        275                 280                 285             


Gly Glu Arg Leu Ser Leu Glu Glu Leu Lys Leu Asn Leu Gln Lys Glu 
    290                 295                 300                 


Ile Ser Leu Ala Lys Ala Lys Tyr Thr Ala Ser Asp Leu Phe Arg Ile 
305                 310                 315                 320 


Pro Met Leu Arg Arg Met Thr Phe Cys Leu Ser Leu Ala Trp Phe Ala 
                325                 330                 335     


Thr Gly Phe Ala Tyr Tyr Ser Leu Ala Met Gly Val Glu Glu Phe Gly 
            340                 345                 350         


Val Asn Leu Tyr Ile Leu Gln Ile Ile Phe Gly Gly Val Asp Val Pro 
        355                 360                 365             


Ala Lys Phe Ile Thr Ile Leu Ser Leu Ser Tyr Leu Gly Arg His Thr 
    370                 375                 380                 


Thr Gln Ala Ala Ala Leu Leu Leu Ala Gly Gly Ala Ile Leu Ala Leu 
385                 390                 395                 400 


Thr Phe Val Pro Leu Asp Leu Gln Thr Val Arg Thr Val Leu Ala Val 
                405                 410                 415     


Phe Gly Lys Gly Cys Leu Ser Ser Ser Phe Ser Cys Leu Phe Leu Tyr 
            420                 425                 430         


Thr Ser Glu Leu Tyr Pro Thr Val Ile Arg Gln Thr Gly Met Gly Val 
        435                 440                 445             


Ser Asn Leu Trp Thr Arg Val Gly Ser Met Val Ser Pro Leu Val Lys 
    450                 455                 460                 


Ile Thr Gly Glu Val Gln Pro Phe Ile Pro Asn Ile Ile Tyr Gly Ile 
465                 470                 475                 480 


Thr Ala Leu Leu Gly Gly Ser Ala Ala Leu Phe Leu Pro Glu Thr Leu 
                485                 490                 495     


Asn Gln Pro Leu Pro Glu Thr Ile Glu Asp Leu Glu Asn Trp Ser Leu 
            500                 505                 510         


Arg Ala Lys Lys Pro Lys Gln Glu Pro Glu Val Glu Lys Ala Ser Gln 
        515                 520                 525             


Arg Ile Pro Leu Gln Pro His Gly Pro Gly Leu Gly Ser Ser 
    530                 535                 540         


<210>  3000
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  3000

Met Ala Gln Phe Val Gln Val Leu Ala Glu Ile Gly Asp Phe Gly Arg 
1               5                   10                  15      


Phe Gln Ile Gln Leu Leu Ile Leu Leu Cys Val Leu Asn Phe Leu Ser 
            20                  25                  30          


Pro Phe Tyr Phe Phe Ala His Val Phe Met Val Leu Asp Glu Pro His 
        35                  40                  45              


His Cys Ala Val Ala Trp Val Lys Asn His Thr Phe Asn Leu Ser Ala 
    50                  55                  60                  


Ala Glu Gln Leu Val Leu Ser Val Pro Leu Asp Thr Ala Gly His Pro 
65                  70                  75                  80  


Glu Pro Cys Leu Met Phe Arg Pro Pro Pro Ala Asn Ala Ser Leu Gln 
                85                  90                  95      


Asp Ile Leu Ser His Arg Phe Asn Glu Thr Gln Pro Cys Asp Met Gly 
            100                 105                 110         


Trp Glu Tyr Pro Glu Asn Arg Leu Pro Ser Leu Lys Asn Glu Phe Asn 
        115                 120                 125             


Leu Val Cys Asp Arg Lys His Leu Lys Asp Thr Thr Gln Ser Val Phe 
    130                 135                 140                 


Met Ala Gly Leu Leu Val Gly Thr Leu Met Phe Gly Pro Leu Cys Asp 
145                 150                 155                 160 


Arg Ile Gly Arg Lys Ala Thr Ile Leu Ala Gln Leu Leu Leu Phe Thr 
                165                 170                 175     


Leu Ile Gly Leu Ala Thr Ala Phe Val Pro Ser Phe Glu Leu Tyr Met 
            180                 185                 190         


Ala Leu Arg Phe Ala Val Ala Thr Ala Val Ala Gly Leu Ser Phe Ser 
        195                 200                 205             


Asn Val Thr Leu Leu Thr Glu Trp Val Gly Pro Ser Trp Arg Thr Gln 
    210                 215                 220                 


Ala Val Val Leu Ala Gln Cys Asn Phe Ser Leu Gly Gln Met Val Leu 
225                 230                 235                 240 


Ala Gly Leu Ala Tyr Gly Phe Arg Asn Trp Arg Leu Leu Gln Ile Thr 
                245                 250                 255     


Gly Thr Ala Pro Gly Leu Leu Leu Phe Phe Tyr Phe Trp Ala Leu Pro 
            260                 265                 270         


Glu Ser Ala Arg Trp Leu Leu Thr Arg Gly Arg Met Asp Glu Ala Ile 
        275                 280                 285             


Gln Leu Ile Gln Lys Ala Ala Ser Val Asn Arg Arg Lys Leu Ser Pro 
    290                 295                 300                 


Glu Leu Met Asn Gln Leu Val Pro Glu Lys Thr Gly Pro Ser Gly Asn 
305                 310                 315                 320 


Ala Leu Asp Leu Phe Arg His Pro Gln Leu Arg Lys Val Thr Leu Ile 
                325                 330                 335     


Ile Phe Cys Val Trp Phe Val Asp Ser Leu Gly Tyr Tyr Gly Leu Ser 
            340                 345                 350         


Leu Gln Val Gly Asp Phe Gly Leu Asp Val Tyr Leu Thr Gln Leu Ile 
        355                 360                 365             


Phe Gly Ala Val Glu Val Pro Ala Arg Cys Ser Ser Ile Phe Met Met 
    370                 375                 380                 


Gln Arg Phe Gly Arg Lys Trp Ser Gln Leu Gly Thr Leu Val Leu Gly 
385                 390                 395                 400 


Gly Leu Met Cys Ile Ile Ile Ile Phe Ile Pro Ala Asp Leu Pro Val 
                405                 410                 415     


Val Val Thr Met Leu Ala Val Val Gly Lys Met Ala Thr Ala Ala Ala 
            420                 425                 430         


Phe Thr Ile Ser Tyr Val Tyr Ser Ala Glu Leu Phe Pro Thr Ile Leu 
        435                 440                 445             


Arg Gln Thr Gly Met Gly Leu Val Gly Ile Phe Ser Arg Ile Gly Gly 
    450                 455                 460                 


Ile Leu Thr Pro Leu Val Ile Leu Leu Gly Glu Tyr His Ala Ala Leu 
465                 470                 475                 480 


Pro Met Leu Ile Tyr Gly Ser Leu Pro Ile Val Ala Gly Leu Leu Cys 
                485                 490                 495     


Thr Leu Leu Pro Glu Thr His Gly Gln Gly Leu Lys Asp Thr Leu Gln 
            500                 505                 510         


Asp Leu Glu Leu Gly Pro His Pro Arg Ser Pro Lys Ser Val Pro Ser 
        515                 520                 525             


Glu Lys Glu Thr Glu Ala Lys Gly Arg Thr Ser Ser Pro Gly Val Ala 
    530                 535                 540                 


Phe Val Ser Ser Thr Tyr Phe 
545                 550     


<210>  3001
<211>  1021
<212>  PRT
<213>  Homo sapiens

<400>  3001

Met Ala Gly Ile Ser Tyr Val Ala Ser Phe Phe Leu Leu Leu Thr Lys 
1               5                   10                  15      


Leu Ser Ile Gly Gln Arg Glu Val Thr Val Gln Lys Gly Pro Leu Phe 
            20                  25                  30          


Arg Ala Glu Gly Tyr Pro Val Ser Ile Gly Cys Asn Val Thr Gly His 
        35                  40                  45              


Gln Gly Pro Ser Glu Gln His Phe Gln Trp Ser Val Tyr Leu Pro Thr 
    50                  55                  60                  


Asn Pro Thr Gln Glu Val Gln Ile Ile Ser Thr Lys Asp Ala Ala Phe 
65                  70                  75                  80  


Ser Tyr Ala Val Tyr Thr Gln Arg Val Arg Ser Gly Asp Val Tyr Val 
                85                  90                  95      


Glu Arg Val Gln Gly Asn Ser Val Leu Leu His Ile Ser Lys Leu Gln 
            100                 105                 110         


Met Lys Asp Ala Gly Glu Tyr Glu Cys His Thr Pro Asn Thr Asp Glu 
        115                 120                 125             


Lys Tyr Tyr Gly Ser Tyr Ser Ala Lys Thr Asn Leu Ile Val Ile Pro 
    130                 135                 140                 


Asp Thr Leu Ser Ala Thr Met Ser Ser Gln Thr Leu Gly Lys Glu Glu 
145                 150                 155                 160 


Gly Glu Pro Leu Ala Leu Thr Cys Glu Ala Ser Lys Ala Thr Ala Gln 
                165                 170                 175     


His Thr His Leu Ser Val Thr Trp Tyr Leu Thr Gln Asp Gly Gly Gly 
            180                 185                 190         


Ser Gln Ala Thr Glu Ile Ile Ser Leu Ser Lys Asp Phe Ile Leu Val 
        195                 200                 205             


Pro Gly Pro Leu Tyr Thr Glu Arg Phe Ala Ala Ser Asp Val Gln Leu 
    210                 215                 220                 


Asn Lys Leu Gly Pro Thr Thr Phe Arg Leu Ser Ile Glu Arg Leu Gln 
225                 230                 235                 240 


Ser Ser Asp Gln Gly Gln Leu Phe Cys Glu Ala Thr Glu Trp Ile Gln 
                245                 250                 255     


Asp Pro Asp Glu Thr Trp Met Phe Ile Thr Lys Lys Gln Thr Asp Gln 
            260                 265                 270         


Thr Thr Leu Arg Ile Gln Pro Ala Val Lys Asp Phe Gln Val Asn Ile 
        275                 280                 285             


Thr Ala Asp Ser Leu Phe Ala Glu Gly Lys Pro Leu Glu Leu Val Cys 
    290                 295                 300                 


Leu Val Val Ser Ser Gly Arg Asp Pro Gln Leu Gln Gly Ile Trp Phe 
305                 310                 315                 320 


Phe Asn Gly Thr Glu Ile Ala His Ile Asp Ala Gly Gly Val Leu Gly 
                325                 330                 335     


Leu Lys Asn Asp Tyr Lys Glu Arg Ala Ser Gln Gly Glu Leu Gln Val 
            340                 345                 350         


Ser Lys Leu Gly Pro Lys Ala Phe Ser Leu Lys Ile Phe Ser Leu Gly 
        355                 360                 365             


Pro Glu Asp Glu Gly Ala Tyr Arg Cys Val Val Ala Glu Val Met Lys 
    370                 375                 380                 


Thr Arg Thr Gly Ser Trp Gln Val Leu Gln Arg Lys Gln Ser Pro Asp 
385                 390                 395                 400 


Ser His Val His Leu Arg Lys Pro Ala Ala Arg Ser Val Val Met Ser 
                405                 410                 415     


Thr Lys Asn Lys Gln Gln Val Val Trp Glu Gly Glu Thr Leu Ala Phe 
            420                 425                 430         


Leu Cys Lys Ala Gly Gly Ala Glu Ser Pro Leu Ser Val Ser Trp Trp 
        435                 440                 445             


His Ile Pro Arg Asp Gln Thr Gln Pro Glu Phe Val Ala Gly Met Gly 
    450                 455                 460                 


Gln Asp Gly Ile Val Gln Leu Gly Ala Ser Tyr Gly Val Pro Ser Tyr 
465                 470                 475                 480 


His Gly Asn Thr Arg Leu Glu Lys Met Asp Trp Ala Thr Phe Gln Leu 
                485                 490                 495     


Glu Ile Thr Phe Thr Ala Ile Thr Asp Ser Gly Thr Tyr Glu Cys Arg 
            500                 505                 510         


Val Ser Glu Lys Ser Arg Asn Gln Ala Arg Asp Leu Ser Trp Thr Gln 
        515                 520                 525             


Lys Ile Ser Val Thr Val Lys Ser Leu Glu Ser Ser Leu Gln Val Ser 
    530                 535                 540                 


Leu Met Ser Arg Gln Pro Gln Val Met Leu Thr Asn Thr Phe Asp Leu 
545                 550                 555                 560 


Ser Cys Val Val Arg Ala Gly Tyr Ser Asp Leu Lys Val Pro Leu Thr 
                565                 570                 575     


Val Thr Trp Gln Phe Gln Pro Ala Ser Ser His Ile Phe His Gln Leu 
            580                 585                 590         


Ile Arg Ile Thr His Asn Gly Thr Ile Glu Trp Gly Asn Phe Leu Ser 
        595                 600                 605             


Arg Phe Gln Lys Lys Thr Lys Val Ser Gln Ser Leu Phe Arg Ser Gln 
    610                 615                 620                 


Leu Leu Val His Asp Ala Thr Glu Glu Glu Thr Gly Val Tyr Gln Cys 
625                 630                 635                 640 


Glu Val Glu Val Tyr Asp Arg Asn Ser Leu Tyr Asn Asn Arg Pro Pro 
                645                 650                 655     


Arg Ala Ser Ala Ile Ser His Pro Leu Arg Ile Ala Val Thr Leu Pro 
            660                 665                 670         


Glu Ser Lys Leu Lys Val Asn Ser Arg Ser Gln Val Gln Glu Leu Ser 
        675                 680                 685             


Ile Asn Ser Asn Thr Asp Ile Glu Cys Ser Ile Leu Ser Arg Ser Asn 
    690                 695                 700                 


Gly Asn Leu Gln Leu Ala Ile Ile Trp Tyr Phe Ser Pro Val Ser Thr 
705                 710                 715                 720 


Asn Ala Ser Trp Leu Lys Ile Leu Glu Met Asp Gln Thr Asn Val Ile 
                725                 730                 735     


Lys Thr Gly Asp Glu Phe His Thr Pro Gln Arg Lys Gln Lys Phe His 
            740                 745                 750         


Thr Glu Lys Val Ser Gln Asp Leu Phe Gln Leu His Ile Leu Asn Val 
        755                 760                 765             


Glu Asp Ser Asp Arg Gly Lys Tyr His Cys Ala Val Glu Glu Trp Leu 
    770                 775                 780                 


Leu Ser Thr Asn Gly Thr Trp His Lys Leu Gly Glu Lys Lys Ser Gly 
785                 790                 795                 800 


Leu Thr Glu Leu Lys Leu Lys Pro Thr Gly Ser Lys Val Arg Val Ser 
                805                 810                 815     


Lys Val Tyr Trp Thr Glu Asn Val Thr Glu His Arg Glu Val Ala Ile 
            820                 825                 830         


Arg Cys Ser Leu Glu Ser Val Gly Ser Ser Ala Thr Leu Tyr Ser Val 
        835                 840                 845             


Met Trp Tyr Trp Asn Arg Glu Asn Ser Gly Ser Lys Leu Leu Val His 
    850                 855                 860                 


Leu Gln His Asp Gly Leu Leu Glu Tyr Gly Glu Glu Gly Leu Arg Arg 
865                 870                 875                 880 


His Leu His Cys Tyr Arg Ser Ser Ser Thr Asp Phe Val Leu Lys Leu 
                885                 890                 895     


His Gln Val Glu Met Glu Asp Ala Gly Met Tyr Trp Cys Arg Val Ala 
            900                 905                 910         


Glu Trp Gln Leu His Gly His Pro Ser Lys Trp Ile Asn Gln Ala Ser 
        915                 920                 925             


Asp Glu Ser Gln Arg Met Val Leu Thr Val Leu Pro Ser Glu Pro Thr 
    930                 935                 940                 


Leu Pro Ser Arg Ile Cys Ser Ser Ala Pro Leu Leu Tyr Phe Leu Phe 
945                 950                 955                 960 


Ile Cys Pro Phe Val Leu Leu Leu Leu Leu Leu Ile Ser Leu Leu Cys 
                965                 970                 975     


Leu Tyr Trp Lys Ala Arg Lys Leu Ser Thr Leu Arg Ser Asn Thr Arg 
            980                 985                 990         


Lys Glu Lys Ala Leu Trp Val Asp  Leu Lys Glu Ala Gly  Gly Val Thr 
        995                 1000                 1005             


Thr Asn  Arg Arg Glu Asp Glu  Glu Glu Asp Glu Gly  Asn 
    1010                 1015                 1020     


<210>  3002
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  3002

Met Tyr Arg Pro Ala Arg Val Thr Ser Thr Ser Arg Phe Leu Asn Pro 
1               5                   10                  15      


Tyr Val Val Cys Phe Ile Val Val Ala Gly Val Val Ile Leu Ala Val 
            20                  25                  30          


Thr Ile Ala Leu Leu Val Tyr Phe Leu Ala Phe Asp Gln Lys Ser Tyr 
        35                  40                  45              


Phe Tyr Arg Ser Ser Phe Gln Leu Leu Asn Val Glu Tyr Asn Ser Gln 
    50                  55                  60                  


Leu Asn Ser Pro Ala Thr Gln Glu Tyr Arg Thr Leu Ser Gly Arg Ile 
65                  70                  75                  80  


Glu Ser Leu Ile Thr Lys Thr Phe Lys Glu Ser Asn Leu Arg Asn Gln 
                85                  90                  95      


Phe Ile Arg Ala His Val Ala Lys Leu Arg Gln Asp Gly Ser Gly Val 
            100                 105                 110         


Arg Ala Asp Val Val Met Lys Phe Gln Phe Thr Arg Asn Asn Asn Gly 
        115                 120                 125             


Ala Ser Met Lys Ser Arg Ile Glu Ser Val Leu Arg Gln Met Leu Asn 
    130                 135                 140                 


Asn Ser Gly Asn Leu Glu Ile Asn Pro Ser Thr Glu Ile Thr Ser Leu 
145                 150                 155                 160 


Thr Asp Gln Ala Ala Ala Asn Trp Leu Ile Asn Glu Cys Gly Ala Gly 
                165                 170                 175     


Pro Asp Leu Ile Thr Leu Ser Glu Gln Arg Ile Leu Gly Gly Thr Glu 
            180                 185                 190         


Ala Glu Glu Gly Ser Trp Pro Trp Gln Val Ser Leu Arg Leu Asn Asn 
        195                 200                 205             


Ala His His Cys Gly Gly Ser Leu Ile Asn Asn Met Trp Ile Leu Thr 
    210                 215                 220                 


Ala Ala His Cys Phe Arg Ser Asn Ser Asn Pro Arg Asp Trp Ile Ala 
225                 230                 235                 240 


Thr Ser Gly Ile Ser Thr Thr Phe Pro Lys Leu Arg Met Arg Val Arg 
                245                 250                 255     


Asn Ile Leu Ile His Asn Asn Tyr Lys Ser Ala Thr His Glu Asn Asp 
            260                 265                 270         


Ile Ala Leu Val Arg Leu Glu Asn Ser Val Thr Phe Thr Lys Asp Ile 
        275                 280                 285             


His Ser Val Cys Leu Pro Ala Ala Thr Gln Asn Ile Pro Pro Gly Ser 
    290                 295                 300                 


Thr Ala Tyr Val Thr Gly Trp Gly Ala Gln Glu Tyr Ala Gly His Thr 
305                 310                 315                 320 


Val Pro Glu Leu Arg Gln Gly Gln Val Arg Ile Ile Ser Asn Asp Val 
                325                 330                 335     


Cys Asn Ala Pro His Ser Tyr Asn Gly Ala Ile Leu Ser Gly Met Leu 
            340                 345                 350         


Cys Ala Gly Val Pro Gln Gly Gly Val Asp Ala Cys Gln Gly Asp Ser 
        355                 360                 365             


Gly Gly Pro Leu Val Gln Glu Asp Ser Arg Arg Leu Trp Phe Ile Val 
    370                 375                 380                 


Gly Ile Val Ser Trp Gly Asp Gln Cys Gly Leu Pro Asp Lys Pro Gly 
385                 390                 395                 400 


Val Tyr Thr Arg Val Thr Ala Tyr Leu Asp Trp Ile Arg Gln Gln Thr 
                405                 410                 415     


Gly Ile 
        


<210>  3003
<211>  770
<212>  PRT
<213>  Homo sapiens

<400>  3003

Met Pro Ala Ser Ala Ala Arg Pro Arg Pro Gly Pro Gly Gln Pro Thr 
1               5                   10                  15      


Ala Ser Pro Phe Pro Leu Leu Leu Leu Ala Val Leu Ser Gly Pro Val 
            20                  25                  30          


Ser Gly Arg Val Pro Arg Ser Val Pro Arg Thr Ser Leu Pro Ile Ser 
        35                  40                  45              


Glu Ala Asp Ser Cys Leu Thr Arg Phe Ala Val Pro His Thr Tyr Asn 
    50                  55                  60                  


Tyr Ser Val Leu Leu Val Asp Pro Ala Ser His Thr Leu Tyr Val Gly 
65                  70                  75                  80  


Ala Arg Asp Thr Ile Phe Ala Leu Ser Leu Pro Phe Ser Gly Glu Arg 
                85                  90                  95      


Pro Arg Arg Ile Asp Trp Met Val Pro Glu Ala His Arg Gln Asn Cys 
            100                 105                 110         


Arg Lys Lys Gly Lys Lys Glu Asp Glu Cys His Asn Phe Val Gln Ile 
        115                 120                 125             


Leu Ala Ile Ala Asn Ala Ser His Leu Leu Thr Cys Gly Thr Phe Ala 
    130                 135                 140                 


Phe Asp Pro Lys Cys Gly Val Ile Asp Val Ser Arg Phe Gln Gln Val 
145                 150                 155                 160 


Glu Arg Leu Glu Ser Gly Arg Gly Lys Cys Pro Phe Glu Pro Ala Gln 
                165                 170                 175     


Arg Ser Ala Ala Val Met Ala Gly Gly Val Leu Tyr Ala Ala Thr Val 
            180                 185                 190         


Lys Asn Tyr Leu Gly Thr Glu Pro Ile Ile Thr Arg Ala Val Gly Arg 
        195                 200                 205             


Ala Glu Asp Trp Ile Arg Thr Asp Thr Leu Pro Ser Trp Leu Asn Ala 
    210                 215                 220                 


Pro Ala Phe Val Ala Ala Val Ala Leu Ser Pro Ala Glu Trp Gly Asp 
225                 230                 235                 240 


Glu Asp Gly Asp Asp Glu Ile Tyr Phe Phe Phe Thr Glu Thr Ser Arg 
                245                 250                 255     


Ala Phe Asp Ser Tyr Glu Arg Ile Lys Val Pro Arg Val Ala Arg Val 
            260                 265                 270         


Cys Ala Gly Asp Leu Gly Gly Arg Lys Thr Leu Gln Gln Arg Trp Thr 
        275                 280                 285             


Thr Phe Leu Lys Ala Asp Leu Leu Cys Pro Gly Pro Glu His Gly Arg 
    290                 295                 300                 


Ala Ser Ser Val Leu Gln Asp Val Ala Val Leu Arg Pro Glu Leu Gly 
305                 310                 315                 320 


Ala Gly Thr Pro Ile Phe Tyr Gly Ile Phe Ser Ser Gln Trp Glu Gly 
                325                 330                 335     


Ala Thr Ile Ser Ala Val Cys Ala Phe Arg Pro Gln Asp Ile Arg Thr 
            340                 345                 350         


Val Leu Asn Gly Pro Phe Arg Glu Leu Lys His Asp Cys Asn Arg Gly 
        355                 360                 365             


Leu Pro Val Val Asp Asn Asp Val Pro Gln Pro Arg Pro Gly Glu Cys 
    370                 375                 380                 


Ile Thr Asn Asn Met Lys Leu Arg His Phe Gly Ser Ser Leu Ser Leu 
385                 390                 395                 400 


Pro Asp Arg Val Leu Thr Phe Ile Arg Asp His Pro Leu Met Asp Arg 
                405                 410                 415     


Pro Val Phe Pro Ala Asp Gly His Pro Leu Leu Val Thr Thr Asp Thr 
            420                 425                 430         


Ala Tyr Leu Arg Val Val Ala His Arg Val Thr Ser Leu Ser Gly Lys 
        435                 440                 445             


Glu Tyr Asp Val Leu Tyr Leu Gly Thr Glu Asp Gly His Leu His Arg 
    450                 455                 460                 


Ala Val Arg Ile Gly Ala Gln Leu Ser Val Leu Glu Asp Leu Ala Leu 
465                 470                 475                 480 


Phe Pro Glu Pro Gln Pro Val Glu Asn Met Lys Leu Tyr His Ser Trp 
                485                 490                 495     


Leu Leu Val Gly Ser Arg Thr Glu Val Thr Gln Val Asn Thr Thr Asn 
            500                 505                 510         


Cys Gly Arg Leu Gln Ser Cys Ser Glu Cys Ile Leu Ala Gln Asp Pro 
        515                 520                 525             


Val Cys Ala Trp Ser Phe Arg Leu Asp Glu Cys Val Ala His Ala Gly 
    530                 535                 540                 


Glu His Arg Gly Leu Val Gln Asp Ile Glu Ser Ala Asp Val Ser Ser 
545                 550                 555                 560 


Leu Cys Pro Lys Glu Pro Gly Glu Arg Pro Val Val Phe Glu Val Pro 
                565                 570                 575     


Val Ala Thr Ala Ala His Val Val Leu Pro Cys Ser Pro Ser Ser Ala 
            580                 585                 590         


Trp Ala Ser Cys Val Trp His Gln Pro Ser Gly Val Thr Ala Leu Thr 
        595                 600                 605             


Pro Arg Arg Asp Gly Leu Glu Val Val Val Thr Pro Gly Ala Met Gly 
    610                 615                 620                 


Ala Tyr Ala Cys Glu Cys Gln Glu Gly Gly Ala Ala His Val Val Ala 
625                 630                 635                 640 


Ala Tyr Ser Leu Val Trp Gly Ser Gln Arg Asp Ala Pro Ser Arg Ala 
                645                 650                 655     


His Thr Val Gly Ala Gly Leu Ala Gly Phe Phe Leu Gly Ile Leu Ala 
            660                 665                 670         


Ala Ser Leu Thr Leu Ile Leu Ile Gly Arg Arg Gln Gln Arg Arg Arg 
        675                 680                 685             


Gln Arg Glu Leu Leu Ala Arg Asp Lys Val Gly Leu Asp Leu Gly Ala 
    690                 695                 700                 


Pro Pro Ser Gly Thr Thr Ser Tyr Ser Gln Asp Pro Pro Ser Pro Ser 
705                 710                 715                 720 


Pro Glu Asp Glu Arg Leu Pro Leu Ala Leu Ala Lys Arg Gly Ser Gly 
                725                 730                 735     


Phe Gly Gly Phe Ser Pro Pro Phe Leu Leu Asp Pro Cys Pro Ser Pro 
            740                 745                 750         


Ala His Ile Arg Leu Thr Gly Ala Pro Leu Ala Thr Cys Asp Glu Thr 
        755                 760                 765             


Ser Ile 
    770 


<210>  3004
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  3004

Met Glu Lys Gly Leu Thr Leu Pro Gln Asp Cys Arg Asp Phe Val His 
1               5                   10                  15      


Ser Leu Lys Met Arg Ser Lys Tyr Ala Leu Phe Leu Val Phe Val Val 
            20                  25                  30          


Ile Val Phe Val Phe Ile Glu Lys Glu Asn Lys Ile Ile Ser Arg Val 
        35                  40                  45              


Ser Asp Lys Leu Lys Gln Ile Pro Gln Ala Leu Ala Asp Ala Asn Ser 
    50                  55                  60                  


Thr Asp Pro Ala Leu Ile Leu Ala Glu Asn Ala Ser Leu Leu Ser Leu 
65                  70                  75                  80  


Ser Glu Leu Asp Ser Ala Phe Ser Gln Leu Gln Ser Arg Leu Arg Asn 
                85                  90                  95      


Leu Ser Leu Gln Leu Gly Val Glu Pro Ala Met Glu Ala Ala Gly Glu 
            100                 105                 110         


Glu Glu Glu Glu Gln Arg Lys Glu Glu Glu Pro Pro Arg Pro Ala Val 
        115                 120                 125             


Ala Gly Pro Arg Arg His Val Leu Leu Met Ala Thr Thr Arg Thr Gly 
    130                 135                 140                 


Ser Ser Phe Val Gly Glu Phe Phe Asn Gln Gln Gly Asn Ile Phe Tyr 
145                 150                 155                 160 


Leu Phe Glu Pro Leu Trp His Ile Glu Arg Thr Val Ser Phe Glu Pro 
                165                 170                 175     


Gly Gly Ala Asn Ala Ala Gly Ser Ala Leu Val Tyr Arg Asp Val Leu 
            180                 185                 190         


Lys Gln Leu Phe Leu Cys Asp Leu Tyr Val Leu Glu His Phe Ile Thr 
        195                 200                 205             


Pro Leu Pro Glu Asp His Leu Thr Gln Phe Met Phe Arg Arg Gly Ser 
    210                 215                 220                 


Ser Arg Ser Leu Cys Glu Asp Pro Val Cys Thr Pro Phe Val Lys Lys 
225                 230                 235                 240 


Val Phe Glu Lys Tyr His Cys Lys Asn Arg Arg Cys Gly Pro Leu Asn 
                245                 250                 255     


Val Thr Leu Ala Ala Glu Ala Cys Arg Arg Lys Glu His Met Ala Leu 
            260                 265                 270         


Lys Ala Val Arg Ile Arg Gln Leu Glu Phe Leu Gln Pro Leu Ala Glu 
        275                 280                 285             


Asp Pro Arg Leu Asp Leu Arg Val Ile Gln Leu Val Arg Asp Pro Arg 
    290                 295                 300                 


Ala Val Leu Ala Ser Arg Met Val Ala Phe Ala Gly Lys Tyr Lys Thr 
305                 310                 315                 320 


Trp Lys Lys Trp Leu Asp Asp Glu Gly Gln Asp Gly Leu Arg Glu Glu 
                325                 330                 335     


Glu Val Gln Arg Leu Arg Gly Asn Cys Glu Ser Ile Arg Leu Ser Ala 
            340                 345                 350         


Glu Leu Gly Leu Arg Gln Pro Ala Trp Leu Arg Gly Arg Tyr Met Leu 
        355                 360                 365             


Val Arg Tyr Glu Asp Val Ala Arg Gly Pro Leu Gln Lys Ala Arg Glu 
    370                 375                 380                 


Met Tyr Arg Phe Ala Gly Ile Pro Leu Thr Pro Gln Val Glu Asp Trp 
385                 390                 395                 400 


Ile Gln Lys Asn Thr Gln Ala Ala His Asp Gly Ser Gly Ile Tyr Ser 
                405                 410                 415     


Thr Gln Lys Asn Ser Ser Glu Gln Phe Glu Lys Trp Arg Phe Ser Met 
            420                 425                 430         


Pro Phe Lys Leu Ala Gln Val Val Gln Ala Ala Cys Gly Pro Ala Met 
        435                 440                 445             


Arg Leu Phe Gly Tyr Lys Leu Ala Arg Asp Ala Ala Ala Leu Thr Asn 
    450                 455                 460                 


Arg Ser Val Ser Leu Leu Glu Glu Arg Gly Thr Phe Trp Val Thr 
465                 470                 475                 


<210>  3005
<211>  2319
<212>  PRT
<213>  Homo sapiens

<400>  3005

Met Leu Thr Met Ser Val Thr Leu Ser Pro Leu Arg Ser Gln Asp Leu 
1               5                   10                  15      


Asp Pro Met Ala Thr Asp Ala Ser Pro Met Ala Ile Asn Met Thr Pro 
            20                  25                  30          


Thr Val Glu Gln Gly Glu Gly Glu Glu Ala Met Lys Asp Met Asp Ser 
        35                  40                  45              


Asp Gln Gln Tyr Glu Lys Pro Pro Pro Leu His Thr Gly Ala Asp Trp 
    50                  55                  60                  


Lys Ile Val Leu His Leu Pro Glu Ile Glu Thr Trp Leu Arg Met Thr 
65                  70                  75                  80  


Ser Glu Arg Val Arg Asp Leu Thr Tyr Ser Val Gln Gln Asp Ser Asp 
                85                  90                  95      


Ser Lys His Val Asp Val His Leu Val Gln Leu Lys Asp Ile Cys Glu 
            100                 105                 110         


Asp Ile Ser Asp His Val Glu Gln Ile His Ala Leu Leu Glu Thr Glu 
        115                 120                 125             


Phe Ser Leu Lys Leu Leu Ser Tyr Ser Val Asn Val Ile Val Asp Ile 
    130                 135                 140                 


His Ala Val Gln Leu Leu Trp His Gln Leu Arg Val Ser Val Leu Val 
145                 150                 155                 160 


Leu Arg Glu Arg Ile Leu Gln Gly Leu Gln Asp Ala Asn Gly Asn Tyr 
                165                 170                 175     


Thr Arg Gln Thr Asp Ile Leu Gln Ala Phe Ser Glu Glu Thr Lys Glu 
            180                 185                 190         


Gly Arg Leu Asp Ser Leu Thr Glu Val Asp Asp Ser Gly Gln Leu Thr 
        195                 200                 205             


Ile Lys Cys Ser Gln Asn Tyr Leu Ser Leu Asp Cys Gly Ile Thr Ala 
    210                 215                 220                 


Phe Glu Leu Ser Asp Tyr Ser Pro Ser Glu Asp Leu Leu Ser Gly Leu 
225                 230                 235                 240 


Gly Asp Met Thr Ser Ser Gln Val Lys Thr Lys Pro Phe Asp Ser Trp 
                245                 250                 255     


Ser Tyr Ser Glu Met Glu Lys Glu Phe Pro Glu Leu Ile Arg Ser Val 
            260                 265                 270         


Gly Leu Leu Thr Val Ala Ala Asp Ser Ile Ser Thr Asn Gly Ser Glu 
        275                 280                 285             


Ala Val Thr Glu Glu Val Ser Gln Val Ser Leu Ser Val Asp Asp Lys 
    290                 295                 300                 


Gly Gly Cys Glu Glu Asp Asn Ala Ser Ala Val Glu Glu Gln Pro Gly 
305                 310                 315                 320 


Leu Thr Leu Gly Val Ser Ser Ser Ser Gly Glu Ala Leu Thr Asn Ala 
                325                 330                 335     


Ala Gln Pro Ser Ser Glu Thr Val Gln Gln Glu Ser Ser Ser Ser Ser 
            340                 345                 350         


His His Asp Ala Lys Asn Gln Gln Pro Val Pro Cys Glu Asn Ala Thr 
        355                 360                 365             


Pro Lys Arg Thr Ile Arg Asp Cys Phe Asn Tyr Asn Glu Asp Ser Pro 
    370                 375                 380                 


Thr Gln Pro Thr Leu Pro Lys Arg Gly Leu Phe Leu Lys Glu Glu Thr 
385                 390                 395                 400 


Phe Lys Asn Asp Leu Lys Gly Asn Gly Gly Lys Arg Gln Met Val Asp 
                405                 410                 415     


Leu Lys Pro Glu Met Ser Arg Ser Thr Pro Ser Leu Val Asp Pro Pro 
            420                 425                 430         


Asp Arg Ser Lys Leu Cys Leu Val Leu Gln Ser Ser Tyr Pro Asn Ser 
        435                 440                 445             


Pro Ser Ala Ala Ser Gln Ser Tyr Glu Cys Leu His Lys Val Gly Asn 
    450                 455                 460                 


Gly Asn Leu Glu Asn Thr Val Lys Phe His Ile Lys Glu Ile Ser Ser 
465                 470                 475                 480 


Ser Leu Gly Arg Leu Asn Asp Cys Tyr Lys Glu Lys Ser Arg Leu Lys 
                485                 490                 495     


Lys Pro His Lys Thr Ser Glu Glu Val Pro Pro Cys Arg Thr Pro Lys 
            500                 505                 510         


Arg Gly Thr Gly Ser Gly Lys Gln Ala Lys Asn Thr Lys Ser Ser Ala 
        515                 520                 525             


Val Pro Asn Gly Glu Leu Ser Tyr Thr Ser Lys Ala Ile Glu Gly Pro 
    530                 535                 540                 


Gln Thr Asn Ser Ala Ser Thr Ser Ser Leu Glu Pro Cys Asn Gln Arg 
545                 550                 555                 560 


Ser Trp Asn Ala Lys Leu Gln Leu Gln Ser Glu Thr Ser Ser Ser Pro 
                565                 570                 575     


Ala Phe Thr Gln Ser Ser Glu Ser Ser Val Gly Ser Asp Asn Ile Met 
            580                 585                 590         


Ser Pro Val Pro Leu Leu Ser Lys His Lys Ser Lys Lys Gly Gln Ala 
        595                 600                 605             


Ser Ser Pro Ser His Val Thr Arg Asn Gly Glu Val Val Glu Ala Trp 
    610                 615                 620                 


Tyr Gly Ser Asp Glu Tyr Leu Ala Leu Pro Ser His Leu Lys Gln Thr 
625                 630                 635                 640 


Glu Val Leu Ala Leu Lys Leu Glu Asn Leu Thr Lys Leu Leu Pro Gln 
                645                 650                 655     


Lys Pro Arg Gly Glu Thr Ile Gln Asn Ile Asp Asp Trp Glu Leu Ser 
            660                 665                 670         


Glu Met Asn Ser Asp Ser Glu Ile Tyr Pro Thr Tyr His Val Lys Lys 
        675                 680                 685             


Lys His Thr Arg Leu Gly Arg Val Ser Pro Ser Ser Ser Ser Asp Ile 
    690                 695                 700                 


Ala Ser Ser Leu Gly Glu Ser Ile Glu Ser Gly Pro Leu Ser Asp Ile 
705                 710                 715                 720 


Leu Ser Asp Glu Glu Ser Ser Met Pro Leu Ala Gly Met Lys Lys Tyr 
                725                 730                 735     


Ala Asp Glu Lys Ser Glu Arg Ala Ser Ser Ser Glu Lys Asn Glu Ser 
            740                 745                 750         


His Ser Ala Thr Lys Ser Ala Leu Ile Gln Lys Leu Met Gln Asp Ile 
        755                 760                 765             


Gln His Gln Asp Asn Tyr Glu Ala Ile Trp Glu Lys Ile Glu Gly Phe 
    770                 775                 780                 


Val Asn Lys Leu Asp Glu Phe Ile Gln Trp Leu Asn Glu Ala Met Glu 
785                 790                 795                 800 


Thr Thr Glu Asn Trp Thr Pro Pro Lys Ala Glu Met Asp Asp Leu Lys 
                805                 810                 815     


Leu Tyr Leu Glu Thr His Leu Ser Phe Lys Leu Asn Val Asp Ser His 
            820                 825                 830         


Cys Ala Leu Lys Glu Ala Val Glu Glu Glu Gly His Gln Leu Leu Glu 
        835                 840                 845             


Leu Ile Ala Ser His Lys Ala Gly Leu Lys Asp Met Leu Arg Met Ile 
    850                 855                 860                 


Ala Ser Gln Trp Lys Glu Leu Gln Arg Gln Ile Lys Arg Gln His Ser 
865                 870                 875                 880 


Trp Ile Leu Arg Ala Leu Asp Thr Ile Lys Ala Glu Ile Leu Ala Thr 
                885                 890                 895     


Asp Val Ser Val Glu Asp Glu Glu Gly Thr Gly Ser Pro Lys Ala Glu 
            900                 905                 910         


Val Gln Leu Cys Tyr Leu Glu Ala Gln Arg Asp Ala Val Glu Gln Met 
        915                 920                 925             


Ser Leu Lys Leu Tyr Ser Glu Gln Tyr Thr Ser Ser Ser Lys Arg Lys 
    930                 935                 940                 


Glu Glu Phe Ala Asp Met Ser Lys Val His Ser Val Gly Ser Asn Gly 
945                 950                 955                 960 


Leu Leu Asp Phe Asp Ser Glu Tyr Gln Glu Leu Trp Asp Trp Leu Ile 
                965                 970                 975     


Asp Met Glu Ser Leu Val Met Asp Ser His Asp Leu Met Met Ser Glu 
            980                 985                 990         


Glu Gln Gln Gln His Leu Tyr Lys  Arg Tyr Ser Val Glu  Met Ser Ile 
        995                 1000                 1005             


Arg His  Leu Lys Lys Thr Glu  Leu Leu Ser Lys Val  Glu Ala Leu 
    1010                 1015                 1020             


Lys Lys  Gly Gly Val Leu Leu  Pro Asn Asp Leu Leu  Glu Lys Val 
    1025                 1030                 1035             


Asp Ser  Ile Asn Glu Lys Trp  Glu Leu Leu Gly Lys  Thr Leu Gly 
    1040                 1045                 1050             


Glu Lys  Ile Gln Asp Thr Met  Ala Gly His Ser Gly  Ser Ser Pro 
    1055                 1060                 1065             


Arg Asp  Leu Leu Ser Pro Glu  Ser Gly Ser Leu Val  Arg Gln Leu 
    1070                 1075                 1080             


Glu Val  Arg Ile Lys Glu Leu  Lys Gly Trp Leu Arg  Asp Thr Glu 
    1085                 1090                 1095             


Leu Phe  Ile Phe Asn Ser Cys  Leu Arg Gln Glu Lys  Glu Gly Thr 
    1100                 1105                 1110             


Met Asn  Thr Glu Lys Gln Leu  Gln Tyr Phe Lys Ser  Leu Cys Arg 
    1115                 1120                 1125             


Glu Ile  Lys Gln Arg Arg Arg  Gly Val Ala Ser Ile  Leu Arg Leu 
    1130                 1135                 1140             


Cys Gln  His Leu Leu Asp Asp  Arg Glu Thr Cys Asn  Leu Asn Ala 
    1145                 1150                 1155             


Asp His  Gln Pro Met Gln Leu  Ile Ile Val Asn Leu  Glu Arg Arg 
    1160                 1165                 1170             


Trp Glu  Ala Ile Val Met Gln  Ala Val Gln Trp Gln  Thr Arg Leu 
    1175                 1180                 1185             


Gln Lys  Lys Met Gly Lys Glu  Ser Glu Thr Leu Asn  Val Ile Asp 
    1190                 1195                 1200             


Pro Gly  Leu Met Asp Leu Asn  Gly Met Ser Glu Asp  Ala Leu Glu 
    1205                 1210                 1215             


Trp Asp  Glu Met Asp Ile Ser  Asn Lys Leu Ile Ser  Leu Asn Glu 
    1220                 1225                 1230             


Glu Ser  Asn Asp Leu Asp Gln  Glu Leu Gln Pro Val  Ile Pro Ser 
    1235                 1240                 1245             


Leu Lys  Leu Gly Glu Thr Ser  Asn Glu Asp Pro Gly  Tyr Asp Glu 
    1250                 1255                 1260             


Glu Ala  Asp Asn His Gly Gly  Ser Gln Tyr Ala Ser  Asn Ile Thr 
    1265                 1270                 1275             


Ala Pro  Ser Ser Pro His Ile  Tyr Gln Val Tyr Ser  Leu His Asn 
    1280                 1285                 1290             


Val Glu  Leu Tyr Glu Asp Asn  His Met Pro Phe Leu  Lys Asn Asn 
    1295                 1300                 1305             


Pro Lys  Val Thr Gly Met Thr  Gln Pro Asn Val Leu  Thr Lys Ser 
    1310                 1315                 1320             


Leu Ser  Lys Asp Ser Ser Phe  Ser Ser Thr Lys Ser  Leu Pro Asp 
    1325                 1330                 1335             


Leu Leu  Gly Gly Ser Asn Leu  Val Lys Pro Cys Ala  Cys His Gly 
    1340                 1345                 1350             


Gly Asp  Met Ser Gln Asn Ser  Gly Ser Glu Ser Gly  Ile Val Ser 
    1355                 1360                 1365             


Glu Gly  Asp Thr Glu Thr Thr  Thr Asn Ser Glu Met  Cys Leu Leu 
    1370                 1375                 1380             


Asn Ala  Val Asp Gly Ser Pro  Ser Asn Leu Glu Thr  Glu His Leu 
    1385                 1390                 1395             


Asp Pro  Gln Met Gly Asp Ala  Val Asn Val Leu Lys  Gln Lys Phe 
    1400                 1405                 1410             


Thr Asp  Glu Gly Glu Ser Ile  Lys Leu Pro Asn Ser  Ser Gln Ser 
    1415                 1420                 1425             


Ser Ile  Ser Pro Val Gly Cys  Val Asn Gly Lys Val  Gly Asp Leu 
    1430                 1435                 1440             


Asn Ser  Ile Thr Lys His Thr  Pro Asp Cys Leu Gly  Glu Glu Leu 
    1445                 1450                 1455             


Gln Gly  Lys His Asp Val Phe  Thr Phe Tyr Asp Tyr  Ser Tyr Leu 
    1460                 1465                 1470             


Gln Gly  Ser Lys Leu Lys Leu  Pro Met Ile Met Lys  Gln Ser Gln 
    1475                 1480                 1485             


Ser Glu  Lys Ala His Val Glu  Asp Pro Leu Leu Arg  Gly Phe Tyr 
    1490                 1495                 1500             


Phe Asp  Lys Lys Ser Cys Lys  Ser Lys His Gln Thr  Thr Glu Leu 
    1505                 1510                 1515             


Gln Pro  Asp Val Pro Pro His  Glu Arg Ile Leu Ala  Ser Ala Ser 
    1520                 1525                 1530             


His Glu  Met Asp Arg Ile Ser  Tyr Lys Ser Gly Asn  Ile Glu Lys 
    1535                 1540                 1545             


Thr Phe  Thr Gly Met Gln Asn  Ala Lys Gln Leu Ser  Leu Leu Ser 
    1550                 1555                 1560             


His Ser  Ser Ser Ile Glu Ser  Leu Ser Pro Gly Gly  Asp Leu Phe 
    1565                 1570                 1575             


Gly Leu  Gly Ile Phe Lys Asn  Gly Ser Asp Ser Leu  Gln Arg Ser 
    1580                 1585                 1590             


Thr Ser  Leu Glu Ser Trp Leu  Thr Ser Tyr Lys Ser  Asn Glu Asp 
    1595                 1600                 1605             


Leu Phe  Ser Cys His Ser Ser  Gly Asp Ile Ser Val  Ser Ser Gly 
    1610                 1615                 1620             


Ser Val  Gly Glu Leu Ser Lys  Arg Thr Leu Asp Leu  Leu Asn Arg 
    1625                 1630                 1635             


Leu Glu  Asn Ile Gln Ser Pro  Ser Glu Gln Lys Ile  Lys Arg Ser 
    1640                 1645                 1650             


Val Ser  Asp Ile Thr Leu Gln  Ser Ser Ser Gln Lys  Met Ser Phe 
    1655                 1660                 1665             


Thr Gly  Gln Met Ser Leu Asp  Ile Ala Ser Ser Ile  Asn Glu Asp 
    1670                 1675                 1680             


Ser Ala  Ala Ser Leu Thr Glu  Leu Ser Ser Ser Asp  Glu Leu Ser 
    1685                 1690                 1695             


Leu Cys  Ser Glu Asp Ile Val  Leu His Lys Asn Lys  Ile Pro Glu 
    1700                 1705                 1710             


Ser Asn  Ala Ser Phe Arg Lys  Arg Leu Thr Arg Ser  Val Ala Asp 
    1715                 1720                 1725             


Glu Ser  Asp Val Asn Val Ser  Met Ile Val Asn Val  Ser Cys Thr 
    1730                 1735                 1740             


Ser Ala  Cys Thr Asp Asp Glu  Asp Asp Ser Asp Leu  Leu Ser Ser 
    1745                 1750                 1755             


Ser Thr  Leu Thr Leu Thr Glu  Glu Glu Leu Cys Ile  Lys Asp Glu 
    1760                 1765                 1770             


Asp Asp  Asp Ser Ser Ile Ala  Thr Asp Asp Glu Ile  Tyr Glu Asp 
    1775                 1780                 1785             


Cys Thr  Leu Met Ser Gly Leu  Asp Tyr Ile Lys Asn  Glu Leu Gln 
    1790                 1795                 1800             


Thr Trp  Ile Arg Pro Lys Leu  Ser Leu Thr Arg Asp  Lys Lys Arg 
    1805                 1810                 1815             


Cys Asn  Val Ser Asp Glu Met  Lys Gly Ser Lys Asp  Ile Ser Ser 
    1820                 1825                 1830             


Ser Glu  Met Thr Asn Pro Ser  Asp Thr Leu Asn Ile  Glu Thr Leu 
    1835                 1840                 1845             


Leu Asn  Gly Ser Val Lys Arg  Val Ser Glu Asn Asn  Gly Asn Gly 
    1850                 1855                 1860             


Lys Asn  Ser Ser His Thr His  Glu Leu Gly Thr Lys  Arg Glu Asn 
    1865                 1870                 1875             


Lys Lys  Thr Ile Phe Lys Val  Asn Lys Asp Pro Tyr  Val Ala Asp 
    1880                 1885                 1890             


Met Glu  Asn Gly Asn Ile Glu  Gly Ile Pro Glu Arg  Gln Lys Gly 
    1895                 1900                 1905             


Lys Pro  Asn Val Thr Ser Lys  Val Ser Glu Asn Leu  Gly Ser His 
    1910                 1915                 1920             


Gly Lys  Glu Ile Ser Glu Ser  Glu His Cys Lys Cys  Lys Ala Leu 
    1925                 1930                 1935             


Met Asp  Ser Leu Asp Asp Ser  Asn Thr Ala Gly Lys  Glu Phe Val 
    1940                 1945                 1950             


Ser Gln  Asp Val Arg His Leu  Pro Lys Lys Cys Pro  Asn His His 
    1955                 1960                 1965             


His Phe  Glu Asn Gln Ser Thr  Ala Ser Thr Pro Thr  Glu Lys Ser 
    1970                 1975                 1980             


Phe Ser  Glu Leu Ala Leu Glu  Thr Arg Phe Asn Asn  Arg Gln Asp 
    1985                 1990                 1995             


Ser Asp  Ala Leu Lys Ser Ser  Asp Asp Ala Pro Ser  Met Ala Gly 
    2000                 2005                 2010             


Lys Ser  Ala Gly Cys Cys Leu  Ala Leu Glu Gln Asn  Gly Thr Glu 
    2015                 2020                 2025             


Glu Asn  Ala Ser Ile Ser Asn  Ile Ser Cys Cys Asn  Cys Glu Pro 
    2030                 2035                 2040             


Asp Val  Phe His Gln Lys Asp  Ala Glu Asp Cys Ser  Val His Asn 
    2045                 2050                 2055             


Phe Val  Lys Glu Ile Ile Asp  Met Ala Ser Thr Ala  Leu Lys Ser 
    2060                 2065                 2070             


Lys Ser  Gln Pro Glu Asn Glu  Val Ala Ala Pro Thr  Ser Leu Thr 
    2075                 2080                 2085             


Gln Ile  Lys Glu Lys Val Leu  Glu His Ser His Arg  Pro Ile Gln 
    2090                 2095                 2100             


Leu Arg  Lys Gly Asp Phe Tyr  Ser Tyr Leu Ser Leu  Ser Ser His 
    2105                 2110                 2115             


Asp Ser  Asp Cys Gly Glu Val  Thr Asn Tyr Ile Glu  Glu Lys Ser 
    2120                 2125                 2130             


Ser Thr  Pro Leu Pro Leu Asp  Thr Thr Asp Ser Gly  Leu Asp Asp 
    2135                 2140                 2145             


Lys Glu  Asp Ile Glu Cys Phe  Phe Glu Ala Cys Val  Glu Gly Asp 
    2150                 2155                 2160             


Ser Asp  Gly Glu Glu Pro Cys  Phe Ser Ser Ala Pro  Pro Asn Glu 
    2165                 2170                 2175             


Ser Ala  Val Pro Ser Glu Ala  Ala Met Pro Leu Gln  Ala Thr Ala 
    2180                 2185                 2190             


Cys Ser  Ser Glu Phe Ser Asp  Ser Ser Leu Ser Ala  Asp Asp Ala 
    2195                 2200                 2205             


Asp Thr  Val Ala Leu Ser Ser  Pro Ser Ser Gln Glu  Arg Ala Glu 
    2210                 2215                 2220             


Val Gly  Lys Glu Val Asn Gly  Leu Pro Gln Thr Ser  Ser Gly Cys 
    2225                 2230                 2235             


Ala Glu  Asn Leu Glu Phe Thr  Pro Ser Lys Leu Asp  Ser Glu Lys 
    2240                 2245                 2250             


Glu Ser  Ser Gly Lys Pro Gly  Glu Ser Gly Met Pro  Glu Glu His 
    2255                 2260                 2265             


Asn Ala  Ala Ser Ala Lys Ser  Lys Val Gln Asp Leu  Ser Leu Lys 
    2270                 2275                 2280             


Ala Asn  Gln Pro Thr Asp Lys  Ala Ala Leu His Pro  Ser Pro Lys 
    2285                 2290                 2295             


Thr Leu  Thr Cys Glu Glu Asn  Leu Leu Asn Leu His  Glu Lys Arg 
    2300                 2305                 2310             


His Arg  Asn Met His Arg 
    2315                 


<210>  3006
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  3006

Met Glu Ala Met Trp Leu Leu Cys Val Ala Leu Ala Val Leu Ala Trp 
1               5                   10                  15      


Gly Phe Leu Trp Val Trp Asp Ser Ser Glu Arg Met Lys Ser Arg Glu 
            20                  25                  30          


Gln Gly Gly Arg Leu Gly Ala Glu Ser Arg Thr Leu Leu Val Ile Ala 
        35                  40                  45              


His Pro Asp Asp Glu Ala Met Phe Phe Ala Pro Thr Val Leu Gly Leu 
    50                  55                  60                  


Ala Arg Leu Arg His Trp Val Tyr Leu Leu Cys Phe Ser Ala Gly Asn 
65                  70                  75                  80  


Tyr Tyr Asn Gln Gly Glu Thr Arg Lys Lys Glu Leu Leu Gln Ser Cys 
                85                  90                  95      


Asp Val Leu Gly Ile Pro Leu Ser Ser Val Met Ile Ile Asp Asn Arg 
            100                 105                 110         


Asp Phe Pro Asp Asp Pro Gly Met Gln Trp Asp Thr Glu His Val Ala 
        115                 120                 125             


Arg Val Leu Leu Gln His Ile Glu Val Asn Gly Ile Asn Leu Val Val 
    130                 135                 140                 


Thr Phe Asp Ala Gly Gly Val Ser Gly His Ser Asn His Ile Ala Leu 
145                 150                 155                 160 


Tyr Ala Ala Val Arg Ala Leu His Ser Glu Gly Lys Leu Pro Lys Gly 
                165                 170                 175     


Cys Ser Val Leu Thr Leu Gln Ser Val Asn Val Leu Arg Lys Tyr Ile 
            180                 185                 190         


Ser Leu Leu Asp Leu Pro Leu Ser Leu Leu His Thr Gln Asp Val Leu 
        195                 200                 205             


Phe Val Leu Asn Ser Lys Glu Val Ala Gln Ala Lys Lys Ala Met Ser 
    210                 215                 220                 


Cys His Arg Ser Gln Leu Leu Trp Phe Arg Arg Leu Tyr Ile Ile Phe 
225                 230                 235                 240 


Ser Arg Tyr Met Arg Ile Asn Ser Leu Ser Phe Leu 
                245                 250         


<210>  3007
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  3007

Met Ala Ala Ala Ala Glu Leu Ser Leu Leu Glu Lys Ser Leu Gly Leu 
1               5                   10                  15      


Ser Lys Gly Asn Lys Tyr Ser Ala Gln Gly Glu Arg Gln Ile Pro Val 
            20                  25                  30          


Leu Gln Thr Asn Asn Gly Pro Ser Leu Thr Gly Leu Thr Thr Ile Ala 
        35                  40                  45              


Ala His Leu Val Lys Gln Ala Asn Lys Glu Tyr Leu Leu Gly Ser Thr 
    50                  55                  60                  


Ala Glu Glu Lys Ala Ile Val Gln Gln Trp Leu Glu Tyr Arg Val Thr 
65                  70                  75                  80  


Gln Val Asp Gly His Ser Ser Lys Asn Asp Ile His Thr Leu Leu Lys 
                85                  90                  95      


Asp Leu Asn Ser Tyr Leu Glu Asp Lys Val Tyr Leu Thr Gly Tyr Asn 
            100                 105                 110         


Phe Thr Leu Ala Asp Ile Leu Leu Tyr Tyr Gly Leu His Arg Phe Ile 
        115                 120                 125             


Val Asp Leu Thr Val Gln Glu Lys Glu Lys Tyr Leu Asn Val Ser Arg 
    130                 135                 140                 


Trp Phe Cys His Ile Gln His Tyr Pro Gly Ile Arg Gln His Leu Ser 
145                 150                 155                 160 


Ser Val Val Phe Ile Lys Asn Arg Leu Tyr Thr Asn Ser His 
                165                 170                 


<210>  3008
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  3008

Met Asp Pro Leu Phe Gln Gln Thr His Lys Gln Val His Glu Ile Gln 
1               5                   10                  15      


Ser Cys Met Gly Arg Leu Glu Thr Ala Asp Lys Gln Ser Val His Ile 
            20                  25                  30          


Val Glu Asn Glu Ile Gln Ala Ser Ile Asp Gln Ile Phe Ser Arg Leu 
        35                  40                  45              


Glu Arg Leu Glu Ile Leu Ser Ser Lys Glu Pro Pro Asn Lys Arg Gln 
    50                  55                  60                  


Asn Ala Arg Leu Arg Val Asp Gln Leu Lys Tyr Asp Val Gln His Leu 
65                  70                  75                  80  


Gln Thr Ala Leu Arg Asn Phe Gln His Arg Arg His Ala Arg Glu Gln 
                85                  90                  95      


Gln Glu Arg Gln Arg Glu Glu Leu Leu Ser Arg Thr Phe Thr Thr Asn 
            100                 105                 110         


Asp Ser Asp Thr Thr Ile Pro Met Asp Glu Ser Leu Gln Phe Asn Ser 
        115                 120                 125             


Ser Leu Gln Lys Val His Asn Gly Met Asp Asp Leu Ile Leu Asp Gly 
    130                 135                 140                 


His Asn Ile Leu Asp Gly Leu Arg Thr Gln Arg Leu Thr Leu Lys Gly 
145                 150                 155                 160 


Thr Gln Lys Lys Ile Leu Asp Ile Ala Asn Met Leu Gly Leu Ser Asn 
                165                 170                 175     


Thr Val Met Arg Leu Ile Glu Lys Arg Ala Phe Gln Asp Lys Tyr Phe 
            180                 185                 190         


Met Ile Gly Gly Met Leu Leu Thr Cys Val Val Met Phe Leu Val Val 
        195                 200                 205             


Gln Tyr Leu Thr 
    210         


<210>  3009
<211>  694
<212>  PRT
<213>  Homo sapiens

<400>  3009

Met Lys His Leu Lys Arg Trp Trp Ser Ala Gly Gly Gly Leu Leu His 
1               5                   10                  15      


Leu Thr Leu Leu Leu Ser Leu Ala Gly Leu Arg Val Asp Leu Asp Leu 
            20                  25                  30          


Tyr Leu Leu Leu Pro Pro Pro Thr Leu Leu Gln Asp Glu Leu Leu Phe 
        35                  40                  45              


Leu Gly Gly Pro Ala Ser Ser Ala Tyr Ala Leu Ser Pro Phe Ser Ala 
    50                  55                  60                  


Ser Gly Gly Trp Gly Arg Ala Gly His Leu His Pro Lys Gly Arg Glu 
65                  70                  75                  80  


Leu Asp Pro Ala Ala Pro Pro Glu Gly Gln Leu Leu Arg Glu Val Arg 
                85                  90                  95      


Ala Leu Gly Val Pro Phe Val Pro Arg Thr Ser Val Asp Ala Trp Leu 
            100                 105                 110         


Val His Ser Val Ala Ala Gly Ser Ala Asp Glu Ala His Gly Leu Leu 
        115                 120                 125             


Gly Ala Ala Ala Ala Ser Ser Thr Gly Gly Ala Gly Ala Ser Val Asp 
    130                 135                 140                 


Gly Gly Ser Gln Ala Val Gln Gly Gly Gly Gly Asp Pro Arg Ala Ala 
145                 150                 155                 160 


Arg Ser Gly Pro Leu Asp Ala Gly Glu Glu Glu Lys Ala Pro Ala Glu 
                165                 170                 175     


Pro Thr Ala Gln Val Pro Asp Ala Gly Gly Cys Ala Ser Glu Glu Asn 
            180                 185                 190         


Gly Val Leu Arg Glu Lys His Glu Ala Val Asp His Ser Ser Gln His 
        195                 200                 205             


Glu Glu Asn Glu Glu Arg Val Ser Ala Gln Lys Glu Asn Ser Leu Gln 
    210                 215                 220                 


Gln Asn Asp Asp Asp Glu Asn Lys Ile Ala Glu Lys Pro Asp Trp Glu 
225                 230                 235                 240 


Ala Glu Lys Thr Thr Glu Ser Arg Asn Glu Arg His Leu Asn Gly Thr 
                245                 250                 255     


Asp Thr Ser Phe Ser Leu Glu Asp Leu Phe Gln Leu Leu Ser Ser Gln 
            260                 265                 270         


Pro Glu Asn Ser Leu Glu Gly Ile Ser Leu Gly Asp Ile Pro Leu Pro 
        275                 280                 285             


Gly Ser Ile Ser Asp Gly Met Asn Ser Ser Ala His Tyr His Val Asn 
    290                 295                 300                 


Phe Ser Gln Ala Ile Ser Gln Asp Val Asn Leu His Glu Ala Ile Leu 
305                 310                 315                 320 


Leu Cys Pro Asn Asn Thr Phe Arg Arg Asp Pro Thr Ala Arg Thr Ser 
                325                 330                 335     


Gln Ser Gln Glu Pro Phe Leu Gln Leu Asn Ser His Thr Thr Asn Pro 
            340                 345                 350         


Glu Gln Thr Leu Pro Gly Thr Asn Leu Thr Gly Phe Leu Ser Pro Val 
        355                 360                 365             


Asp Asn His Met Arg Asn Leu Thr Ser Gln Asp Leu Leu Tyr Asp Leu 
    370                 375                 380                 


Asp Ile Asn Ile Phe Asp Glu Ile Asn Leu Met Ser Leu Ala Thr Glu 
385                 390                 395                 400 


Asp Asn Phe Asp Pro Ile Asp Val Ser Gln Leu Phe Asp Glu Pro Asp 
                405                 410                 415     


Ser Asp Ser Gly Leu Ser Leu Asp Ser Ser His Asn Asn Thr Ser Val 
            420                 425                 430         


Ile Lys Ser Asn Ser Ser His Ser Val Cys Asp Glu Gly Ala Ile Gly 
        435                 440                 445             


Tyr Cys Thr Asp His Glu Ser Ser Ser His His Asp Leu Glu Gly Ala 
    450                 455                 460                 


Val Gly Gly Tyr Tyr Pro Glu Pro Ser Lys Leu Cys His Leu Asp Gln 
465                 470                 475                 480 


Ser Asp Ser Asp Phe His Gly Asp Leu Thr Phe Gln His Val Phe His 
                485                 490                 495     


Asn His Thr Tyr His Leu Gln Pro Thr Ala Pro Glu Ser Thr Ser Glu 
            500                 505                 510         


Pro Phe Pro Trp Pro Gly Lys Ser Gln Lys Ile Arg Ser Arg Tyr Leu 
        515                 520                 525             


Glu Asp Thr Asp Arg Asn Leu Ser Arg Asp Glu Gln Arg Ala Lys Ala 
    530                 535                 540                 


Leu His Ile Pro Phe Ser Val Asp Glu Ile Val Gly Met Pro Val Asp 
545                 550                 555                 560 


Ser Phe Asn Ser Met Leu Ser Arg Tyr Tyr Leu Thr Asp Leu Gln Val 
                565                 570                 575     


Ser Leu Ile Arg Asp Ile Arg Arg Arg Gly Lys Asn Lys Val Ala Ala 
            580                 585                 590         


Gln Asn Cys Arg Lys Arg Lys Leu Asp Ile Ile Leu Asn Leu Glu Asp 
        595                 600                 605             


Asp Val Cys Asn Leu Gln Ala Lys Lys Glu Thr Leu Lys Arg Glu Gln 
    610                 615                 620                 


Ala Gln Cys Asn Lys Ala Ile Asn Ile Met Lys Gln Lys Leu His Asp 
625                 630                 635                 640 


Leu Tyr His Asp Ile Phe Ser Arg Leu Arg Asp Asp Gln Gly Arg Pro 
                645                 650                 655     


Val Asn Pro Asn His Tyr Ala Leu Gln Cys Thr His Asp Gly Ser Ile 
            660                 665                 670         


Leu Ile Val Pro Lys Glu Leu Val Ala Ser Gly His Lys Lys Glu Thr 
        675                 680                 685             


Gln Lys Gly Lys Arg Lys 
    690                 


<210>  3010
<211>  753
<212>  PRT
<213>  Homo sapiens

<400>  3010

Met Ala Leu Leu Ala Met His Ser Trp Arg Trp Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Phe Glu Lys Arg Arg His Ser Ala Ile Leu Ile Arg Pro Leu Val 
            20                  25                  30          


Ser Val Ser Gly Ser Gly Pro Gln Trp Arg Pro His Gln Leu Gly Ala 
        35                  40                  45              


Leu Gly Thr Ala Arg Ala Tyr Gln Gln Ile Pro Glu Ser Leu Lys Ser 
    50                  55                  60                  


Ile Thr Trp Gln Arg Leu Gly Lys Gly Asn Ser Gly Gln Phe Leu Asp 
65                  70                  75                  80  


Ala Ala Lys Ala Leu Gln Val Trp Pro Leu Ile Glu Lys Arg Thr Cys 
                85                  90                  95      


Trp His Gly His Ala Gly Gly Gly Leu His Thr Asp Pro Lys Glu Gly 
            100                 105                 110         


Leu Lys Asp Val Asp Thr Arg Lys Ile Ile Lys Ala Met Leu Ser Tyr 
        115                 120                 125             


Val Trp Pro Lys Asp Arg Pro Asp Leu Arg Ala Arg Val Ala Ile Ser 
    130                 135                 140                 


Leu Gly Phe Leu Gly Gly Ala Lys Ala Met Asn Ile Val Val Pro Phe 
145                 150                 155                 160 


Met Phe Lys Tyr Ala Val Asp Ser Leu Asn Gln Met Ser Gly Asn Met 
                165                 170                 175     


Leu Asn Leu Ser Asp Ala Pro Asn Thr Val Ala Thr Met Ala Thr Ala 
            180                 185                 190         


Val Leu Ile Gly Tyr Gly Val Ser Arg Ala Gly Ala Ala Phe Phe Asn 
        195                 200                 205             


Glu Val Arg Asn Ala Val Phe Gly Lys Val Ala Gln Asn Ser Ile Arg 
    210                 215                 220                 


Arg Ile Ala Lys Asn Val Phe Leu His Leu His Asn Leu Asp Leu Gly 
225                 230                 235                 240 


Phe His Leu Ser Arg Gln Thr Gly Ala Leu Ser Lys Ala Ile Asp Arg 
                245                 250                 255     


Gly Thr Arg Gly Ile Ser Phe Val Leu Ser Ala Leu Val Phe Asn Leu 
            260                 265                 270         


Leu Pro Ile Met Phe Glu Val Met Leu Val Ser Gly Val Leu Tyr Tyr 
        275                 280                 285             


Lys Cys Gly Ala Gln Phe Ala Leu Val Thr Leu Gly Thr Leu Gly Thr 
    290                 295                 300                 


Tyr Thr Ala Phe Thr Val Ala Val Thr Arg Trp Arg Thr Arg Phe Arg 
305                 310                 315                 320 


Ile Glu Met Asn Lys Ala Asp Asn Asp Ala Gly Asn Ala Ala Ile Asp 
                325                 330                 335     


Ser Leu Leu Asn Tyr Glu Thr Val Lys Tyr Phe Asn Asn Glu Arg Tyr 
            340                 345                 350         


Glu Ala Gln Arg Tyr Asp Gly Phe Leu Lys Thr Tyr Glu Thr Ala Ser 
        355                 360                 365             


Leu Lys Ser Thr Ser Thr Leu Ala Met Leu Asn Phe Gly Gln Ser Ala 
    370                 375                 380                 


Ile Phe Ser Val Gly Leu Thr Ala Ile Met Val Leu Ala Ser Gln Gly 
385                 390                 395                 400 


Ile Val Ala Gly Thr Leu Thr Val Gly Asp Leu Val Met Val Asn Gly 
                405                 410                 415     


Leu Leu Phe Gln Leu Ser Leu Pro Leu Asn Phe Leu Gly Thr Val Tyr 
            420                 425                 430         


Arg Glu Thr Arg Gln Ala Leu Ile Asp Met Asn Thr Leu Phe Thr Leu 
        435                 440                 445             


Leu Lys Val Asp Thr Gln Ile Lys Asp Lys Val Met Ala Ser Pro Leu 
    450                 455                 460                 


Gln Ile Thr Pro Gln Thr Ala Thr Val Ala Phe Asp Asn Val His Phe 
465                 470                 475                 480 


Glu Tyr Ile Glu Gly Gln Lys Val Leu Ser Gly Ile Ser Phe Glu Val 
                485                 490                 495     


Pro Ala Gly Lys Lys Val Ala Ile Val Gly Gly Ser Gly Ser Gly Lys 
            500                 505                 510         


Ser Thr Ile Val Arg Leu Leu Phe Arg Phe Tyr Glu Pro Gln Lys Gly 
        515                 520                 525             


Ser Ile Tyr Leu Ala Gly Gln Asn Ile Gln Asp Val Ser Leu Glu Ser 
    530                 535                 540                 


Leu Arg Arg Ala Val Gly Val Val Pro Gln Asp Ala Val Leu Phe His 
545                 550                 555                 560 


Asn Thr Ile Tyr Tyr Asn Leu Leu Tyr Gly Asn Ile Ser Ala Ser Pro 
                565                 570                 575     


Glu Glu Val Tyr Ala Val Ala Lys Leu Ala Gly Leu His Asp Ala Ile 
            580                 585                 590         


Leu Arg Met Pro His Gly Tyr Asp Thr Gln Val Gly Glu Arg Gly Leu 
        595                 600                 605             


Lys Leu Ser Gly Gly Glu Lys Gln Arg Val Ala Ile Ala Arg Ala Ile 
    610                 615                 620                 


Leu Lys Asp Pro Pro Val Ile Leu Tyr Asp Glu Ala Thr Ser Ser Leu 
625                 630                 635                 640 


Asp Ser Ile Thr Glu Glu Thr Ile Leu Gly Ala Met Lys Asp Val Val 
                645                 650                 655     


Lys His Arg Thr Ser Ile Phe Ile Ala His Arg Leu Ser Thr Val Val 
            660                 665                 670         


Asp Ala Asp Glu Ile Ile Val Leu Asp Gln Gly Lys Val Ala Glu Arg 
        675                 680                 685             


Gly Thr His His Gly Leu Leu Ala Asn Pro His Ser Ile Tyr Ser Glu 
    690                 695                 700                 


Met Trp His Thr Gln Ser Ser Arg Val Gln Asn His Asp Asn Pro Lys 
705                 710                 715                 720 


Trp Glu Ala Lys Lys Glu Asn Ile Ser Lys Glu Glu Glu Arg Lys Lys 
                725                 730                 735     


Leu Gln Glu Glu Ile Val Asn Ser Val Lys Gly Cys Gly Asn Cys Ser 
            740                 745                 750         


Cys 
    


<210>  3011
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  3011

Met Ala Glu Gln Ala Thr Lys Ser Val Leu Phe Val Cys Leu Gly Asn 
1               5                   10                  15      


Ile Cys Arg Ser Pro Ile Ala Glu Ala Val Phe Arg Lys Leu Val Thr 
            20                  25                  30          


Asp Gln Asn Ile Ser Glu Asn Trp Arg Val Asp Ser Ala Ala Thr Ser 
        35                  40                  45              


Gly Tyr Glu Ile Gly Asn Pro Pro Asp Tyr Arg Gly Gln Ser Cys Met 
    50                  55                  60                  


Lys Arg His Gly Ile Pro Met Ser His Val Ala Arg Gln Ile Thr Lys 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Phe Asp Tyr Ile Leu Cys Met Asp Glu Ser Asn 
                85                  90                  95      


Leu Arg Asp Leu Asn Arg Lys Ser Asn Gln Val Lys Thr Cys Lys Ala 
            100                 105                 110         


Lys Ile Glu Leu Leu Gly Ser Tyr Asp Pro Gln Lys Gln Leu Ile Ile 
        115                 120                 125             


Glu Asp Pro Tyr Tyr Gly Asn Asp Ser Asp Phe Glu Thr Val Tyr Gln 
    130                 135                 140                 


Gln Cys Val Arg Cys Cys Arg Ala Phe Leu Glu Lys Ala His 
145                 150                 155             


<210>  3012
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  3012

Met Ala Glu Ser Ala Gly Ala Ser Ser Phe Phe Pro Leu Val Val Leu 
1               5                   10                  15      


Leu Leu Ala Gly Ser Gly Gly Ser Gly Pro Arg Gly Val Gln Ala Leu 
            20                  25                  30          


Leu Cys Ala Cys Thr Ser Cys Leu Gln Ala Asn Tyr Thr Cys Glu Thr 
        35                  40                  45              


Asp Gly Ala Cys Met Val Ser Ile Phe Asn Leu Asp Gly Met Glu His 
    50                  55                  60                  


His Val Arg Thr Cys Ile Pro Lys Val Glu Leu Val Pro Ala Gly Lys 
65                  70                  75                  80  


Pro Phe Tyr Cys Leu Ser Ser Glu Asp Leu Arg Asn Thr His Cys Cys 
                85                  90                  95      


Tyr Thr Asp Tyr Cys Asn Arg Ile Asp Leu Arg Val Pro Ser Gly His 
            100                 105                 110         


Leu Lys Glu Pro Glu His Pro Ser Met Trp Gly Pro Val Glu Leu Val 
        115                 120                 125             


Gly Ile Ile Ala Gly Pro Val Phe Leu Leu Phe Leu Ile Ile Ile Ile 
    130                 135                 140                 


Val Phe Leu Val Ile Asn Tyr His Gln Arg Val Tyr His Asn Arg Gln 
145                 150                 155                 160 


Arg Leu Asp Met Glu Asp Pro Ser Cys Glu Met Cys Leu Ser Lys Asp 
                165                 170                 175     


Lys Thr Leu Gln Asp Leu Val Tyr Asp Leu Ser Thr Ser Gly Ser Gly 
            180                 185                 190         


Ser Gly Leu Pro Leu Phe Val Gln Arg Thr Val Ala Arg Thr Ile Val 
        195                 200                 205             


Leu Gln Glu Ile Ile Gly Lys Gly Arg Phe Gly Glu Val Trp Arg Gly 
    210                 215                 220                 


Arg Trp Arg Gly Gly Asp Val Ala Val Lys Ile Phe Ser Ser Arg Glu 
225                 230                 235                 240 


Glu Arg Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Thr Val Met Leu 
                245                 250                 255     


Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys Asp Asn 
            260                 265                 270         


Gly Thr Trp Thr Gln Leu Trp Leu Val Ser Asp Tyr His Glu His Gly 
        275                 280                 285             


Ser Leu Phe Asp Tyr Leu Asn Arg Tyr Thr Val Thr Ile Glu Gly Met 
    290                 295                 300                 


Ile Lys Leu Ala Leu Ser Ala Ala Ser Gly Leu Ala His Leu His Met 
305                 310                 315                 320 


Glu Ile Val Gly Thr Gln Gly Lys Pro Gly Ile Ala His Arg Asp Leu 
                325                 330                 335     


Lys Ser Lys Asn Ile Leu Val Lys Lys Asn Gly Met Cys Ala Ile Ala 
            340                 345                 350         


Asp Leu Gly Leu Ala Val Arg His Asp Ala Val Thr Asp Thr Ile Asp 
        355                 360                 365             


Ile Ala Pro Asn Gln Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu 
    370                 375                 380                 


Val Leu Asp Glu Thr Ile Asn Met Lys His Phe Asp Ser Phe Lys Cys 
385                 390                 395                 400 


Ala Asp Ile Tyr Ala Leu Gly Leu Val Tyr Trp Glu Ile Ala Arg Arg 
                405                 410                 415     


Cys Asn Ser Gly Gly Val His Glu Glu Tyr Gln Leu Pro Tyr Tyr Asp 
            420                 425                 430         


Leu Val Pro Ser Asp Pro Ser Ile Glu Glu Met Arg Lys Val Val Cys 
        435                 440                 445             


Asp Gln Lys Leu Arg Pro Asn Ile Pro Asn Trp Trp Gln Ser Tyr Glu 
    450                 455                 460                 


Ala Leu Arg Val Met Gly Lys Met Met Arg Glu Cys Trp Tyr Ala Asn 
465                 470                 475                 480 


Gly Ala Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Ser Gln 
                485                 490                 495     


Leu Ser Val Gln Glu Asp Val Lys Ile 
            500                 505 


<210>  3013
<211>  1620
<212>  PRT
<213>  Homo sapiens

<400>  3013

Met Gly Ala Ile Gly Leu Leu Trp Leu Leu Pro Leu Leu Leu Ser Thr 
1               5                   10                  15      


Ala Ala Val Gly Ser Gly Met Gly Thr Gly Gln Arg Ala Gly Ser Pro 
            20                  25                  30          


Ala Ala Gly Pro Pro Leu Gln Pro Arg Glu Pro Leu Ser Tyr Ser Arg 
        35                  40                  45              


Leu Gln Arg Lys Ser Leu Ala Val Asp Phe Val Val Pro Ser Leu Phe 
    50                  55                  60                  


Arg Val Tyr Ala Arg Asp Leu Leu Leu Pro Pro Ser Ser Ser Glu Leu 
65                  70                  75                  80  


Lys Ala Gly Arg Pro Glu Ala Arg Gly Ser Leu Ala Leu Asp Cys Ala 
                85                  90                  95      


Pro Leu Leu Arg Leu Leu Gly Pro Ala Pro Gly Val Ser Trp Thr Ala 
            100                 105                 110         


Gly Ser Pro Ala Pro Ala Glu Ala Arg Thr Leu Ser Arg Val Leu Lys 
        115                 120                 125             


Gly Gly Ser Val Arg Lys Leu Arg Arg Ala Lys Gln Leu Val Leu Glu 
    130                 135                 140                 


Leu Gly Glu Glu Ala Ile Leu Glu Gly Cys Val Gly Pro Pro Gly Glu 
145                 150                 155                 160 


Ala Ala Val Gly Leu Leu Gln Phe Asn Leu Ser Glu Leu Phe Ser Trp 
                165                 170                 175     


Trp Ile Arg Gln Gly Glu Gly Arg Leu Arg Ile Arg Leu Met Pro Glu 
            180                 185                 190         


Lys Lys Ala Ser Glu Val Gly Arg Glu Gly Arg Leu Ser Ala Ala Ile 
        195                 200                 205             


Arg Ala Ser Gln Pro Arg Leu Leu Phe Gln Ile Phe Gly Thr Gly His 
    210                 215                 220                 


Ser Ser Leu Glu Ser Pro Thr Asn Met Pro Ser Pro Ser Pro Asp Tyr 
225                 230                 235                 240 


Phe Thr Trp Asn Leu Thr Trp Ile Met Lys Asp Ser Phe Pro Phe Leu 
                245                 250                 255     


Ser His Arg Ser Arg Tyr Gly Leu Glu Cys Ser Phe Asp Phe Pro Cys 
            260                 265                 270         


Glu Leu Glu Tyr Ser Pro Pro Leu His Asp Leu Arg Asn Gln Ser Trp 
        275                 280                 285             


Ser Trp Arg Arg Ile Pro Ser Glu Glu Ala Ser Gln Met Asp Leu Leu 
    290                 295                 300                 


Asp Gly Pro Gly Ala Glu Arg Ser Lys Glu Met Pro Arg Gly Ser Phe 
305                 310                 315                 320 


Leu Leu Leu Asn Thr Ser Ala Asp Ser Lys His Thr Ile Leu Ser Pro 
                325                 330                 335     


Trp Met Arg Ser Ser Ser Glu His Cys Thr Leu Ala Val Ser Val His 
            340                 345                 350         


Arg His Leu Gln Pro Ser Gly Arg Tyr Ile Ala Gln Leu Leu Pro His 
        355                 360                 365             


Asn Glu Ala Ala Arg Glu Ile Leu Leu Met Pro Thr Pro Gly Lys His 
    370                 375                 380                 


Gly Trp Thr Val Leu Gln Gly Arg Ile Gly Arg Pro Asp Asn Pro Phe 
385                 390                 395                 400 


Arg Val Ala Leu Glu Tyr Ile Ser Ser Gly Asn Arg Ser Leu Ser Ala 
                405                 410                 415     


Val Asp Phe Phe Ala Leu Lys Asn Cys Ser Glu Gly Thr Ser Pro Gly 
            420                 425                 430         


Ser Lys Met Ala Leu Gln Ser Ser Phe Thr Cys Trp Asn Gly Thr Val 
        435                 440                 445             


Leu Gln Leu Gly Gln Ala Cys Asp Phe His Gln Asp Cys Ala Gln Gly 
    450                 455                 460                 


Glu Asp Glu Ser Gln Met Cys Arg Lys Leu Pro Val Gly Phe Tyr Cys 
465                 470                 475                 480 


Asn Phe Glu Asp Gly Phe Cys Gly Trp Thr Gln Gly Thr Leu Ser Pro 
                485                 490                 495     


His Thr Pro Gln Trp Gln Val Arg Thr Leu Lys Asp Ala Arg Phe Gln 
            500                 505                 510         


Asp His Gln Asp His Ala Leu Leu Leu Ser Thr Thr Asp Val Pro Ala 
        515                 520                 525             


Ser Glu Ser Ala Thr Val Thr Ser Ala Thr Phe Pro Ala Pro Ile Lys 
    530                 535                 540                 


Ser Ser Pro Cys Glu Leu Arg Met Ser Trp Leu Ile Arg Gly Val Leu 
545                 550                 555                 560 


Arg Gly Asn Val Ser Leu Val Leu Val Glu Asn Lys Thr Gly Lys Glu 
                565                 570                 575     


Gln Gly Arg Met Val Trp His Val Ala Ala Tyr Glu Gly Leu Ser Leu 
            580                 585                 590         


Trp Gln Trp Met Val Leu Pro Leu Leu Asp Val Ser Asp Arg Phe Trp 
        595                 600                 605             


Leu Gln Met Val Ala Trp Trp Gly Gln Gly Ser Arg Ala Ile Val Ala 
    610                 615                 620                 


Phe Asp Asn Ile Ser Ile Ser Leu Asp Cys Tyr Leu Thr Ile Ser Gly 
625                 630                 635                 640 


Glu Asp Lys Ile Leu Gln Asn Thr Ala Pro Lys Ser Arg Asn Leu Phe 
                645                 650                 655     


Glu Arg Asn Pro Asn Lys Glu Leu Lys Pro Gly Glu Asn Ser Pro Arg 
            660                 665                 670         


Gln Thr Pro Ile Phe Asp Pro Thr Val His Trp Leu Phe Thr Thr Cys 
        675                 680                 685             


Gly Ala Ser Gly Pro His Gly Pro Thr Gln Ala Gln Cys Asn Asn Ala 
    690                 695                 700                 


Tyr Gln Asn Ser Asn Leu Ser Val Glu Val Gly Ser Glu Gly Pro Leu 
705                 710                 715                 720 


Lys Gly Ile Gln Ile Trp Lys Val Pro Ala Thr Asp Thr Tyr Ser Ile 
                725                 730                 735     


Ser Gly Tyr Gly Ala Ala Gly Gly Lys Gly Gly Lys Asn Thr Met Met 
            740                 745                 750         


Arg Ser His Gly Val Ser Val Leu Gly Ile Phe Asn Leu Glu Lys Asp 
        755                 760                 765             


Asp Met Leu Tyr Ile Leu Val Gly Gln Gln Gly Glu Asp Ala Cys Pro 
    770                 775                 780                 


Ser Thr Asn Gln Leu Ile Gln Lys Val Cys Ile Gly Glu Asn Asn Val 
785                 790                 795                 800 


Ile Glu Glu Glu Ile Arg Val Asn Arg Ser Val His Glu Trp Ala Gly 
                805                 810                 815     


Gly Gly Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Lys Met Lys Asp 
            820                 825                 830         


Gly Val Pro Val Pro Leu Ile Ile Ala Ala Gly Gly Gly Gly Arg Ala 
        835                 840                 845             


Tyr Gly Ala Lys Thr Asp Thr Phe His Pro Glu Arg Leu Glu Asn Asn 
    850                 855                 860                 


Ser Ser Val Leu Gly Leu Asn Gly Asn Ser Gly Ala Ala Gly Gly Gly 
865                 870                 875                 880 


Gly Gly Trp Asn Asp Asn Thr Ser Leu Leu Trp Ala Gly Lys Ser Leu 
                885                 890                 895     


Gln Glu Gly Ala Thr Gly Gly His Ser Cys Pro Gln Ala Met Lys Lys 
            900                 905                 910         


Trp Gly Trp Glu Thr Arg Gly Gly Phe Gly Gly Gly Gly Gly Gly Cys 
        915                 920                 925             


Ser Ser Gly Gly Gly Gly Gly Gly Tyr Ile Gly Gly Asn Ala Ala Ser 
    930                 935                 940                 


Asn Asn Asp Pro Glu Met Asp Gly Glu Asp Gly Val Ser Phe Ile Ser 
945                 950                 955                 960 


Pro Leu Gly Ile Leu Tyr Thr Pro Ala Leu Lys Val Met Glu Gly His 
                965                 970                 975     


Gly Glu Val Asn Ile Lys His Tyr Leu Asn Cys Ser His Cys Glu Val 
            980                 985                 990         


Asp Glu Cys His Met Asp Pro Glu  Ser His Lys Val Ile  Cys Phe Cys 
        995                 1000                 1005             


Asp His  Gly Thr Val Leu Ala  Glu Asp Gly Val Ser  Cys Ile Val 
    1010                 1015                 1020             


Ser Pro  Thr Pro Glu Pro His  Leu Pro Leu Ser Leu  Ile Leu Ser 
    1025                 1030                 1035             


Val Val  Thr Ser Ala Leu Val  Ala Ala Leu Val Leu  Ala Phe Ser 
    1040                 1045                 1050             


Gly Ile  Met Ile Val Tyr Arg  Arg Lys His Gln Glu  Leu Gln Ala 
    1055                 1060                 1065             


Met Gln  Met Glu Leu Gln Ser  Pro Glu Tyr Lys Leu  Ser Lys Leu 
    1070                 1075                 1080             


Arg Thr  Ser Thr Ile Met Thr  Asp Tyr Asn Pro Asn  Tyr Cys Phe 
    1085                 1090                 1095             


Ala Gly  Lys Thr Ser Ser Ile  Ser Asp Leu Lys Glu  Val Pro Arg 
    1100                 1105                 1110             


Lys Asn  Ile Thr Leu Ile Arg  Gly Leu Gly His Gly  Ala Phe Gly 
    1115                 1120                 1125             


Glu Val  Tyr Glu Gly Gln Val  Ser Gly Met Pro Asn  Asp Pro Ser 
    1130                 1135                 1140             


Pro Leu  Gln Val Ala Val Lys  Thr Leu Pro Glu Val  Cys Ser Glu 
    1145                 1150                 1155             


Gln Asp  Glu Leu Asp Phe Leu  Met Glu Ala Leu Ile  Ile Ser Lys 
    1160                 1165                 1170             


Phe Asn  His Gln Asn Ile Val  Arg Cys Ile Gly Val  Ser Leu Gln 
    1175                 1180                 1185             


Ser Leu  Pro Arg Phe Ile Leu  Leu Glu Leu Met Ala  Gly Gly Asp 
    1190                 1195                 1200             


Leu Lys  Ser Phe Leu Arg Glu  Thr Arg Pro Arg Pro  Ser Gln Pro 
    1205                 1210                 1215             


Ser Ser  Leu Ala Met Leu Asp  Leu Leu His Val Ala  Arg Asp Ile 
    1220                 1225                 1230             


Ala Cys  Gly Cys Gln Tyr Leu  Glu Glu Asn His Phe  Ile His Arg 
    1235                 1240                 1245             


Asp Ile  Ala Ala Arg Asn Cys  Leu Leu Thr Cys Pro  Gly Pro Gly 
    1250                 1255                 1260             


Arg Val  Ala Lys Ile Gly Asp  Phe Gly Met Ala Arg  Asp Ile Tyr 
    1265                 1270                 1275             


Arg Ala  Ser Tyr Tyr Arg Lys  Gly Gly Cys Ala Met  Leu Pro Val 
    1280                 1285                 1290             


Lys Trp  Met Pro Pro Glu Ala  Phe Met Glu Gly Ile  Phe Thr Ser 
    1295                 1300                 1305             


Lys Thr  Asp Thr Trp Ser Phe  Gly Val Leu Leu Trp  Glu Ile Phe 
    1310                 1315                 1320             


Ser Leu  Gly Tyr Met Pro Tyr  Pro Ser Lys Ser Asn  Gln Glu Val 
    1325                 1330                 1335             


Leu Glu  Phe Val Thr Ser Gly  Gly Arg Met Asp Pro  Pro Lys Asn 
    1340                 1345                 1350             


Cys Pro  Gly Pro Val Tyr Arg  Ile Met Thr Gln Cys  Trp Gln His 
    1355                 1360                 1365             


Gln Pro  Glu Asp Arg Pro Asn  Phe Ala Ile Ile Leu  Glu Arg Ile 
    1370                 1375                 1380             


Glu Tyr  Cys Thr Gln Asp Pro  Asp Val Ile Asn Thr  Ala Leu Pro 
    1385                 1390                 1395             


Ile Glu  Tyr Gly Pro Leu Val  Glu Glu Glu Glu Lys  Val Pro Val 
    1400                 1405                 1410             


Arg Pro  Lys Asp Pro Glu Gly  Val Pro Pro Leu Leu  Val Ser Gln 
    1415                 1420                 1425             


Gln Ala  Lys Arg Glu Glu Glu  Arg Ser Pro Ala Ala  Pro Pro Pro 
    1430                 1435                 1440             


Leu Pro  Thr Thr Ser Ser Gly  Lys Ala Ala Lys Lys  Pro Thr Ala 
    1445                 1450                 1455             


Ala Glu  Ile Ser Val Arg Val  Pro Arg Gly Pro Ala  Val Glu Gly 
    1460                 1465                 1470             


Gly His  Val Asn Met Ala Phe  Ser Gln Ser Asn Pro  Pro Ser Glu 
    1475                 1480                 1485             


Leu His  Lys Val His Gly Ser  Arg Asn Lys Pro Thr  Ser Leu Trp 
    1490                 1495                 1500             


Asn Pro  Thr Tyr Gly Ser Trp  Phe Thr Glu Lys Pro  Thr Lys Lys 
    1505                 1510                 1515             


Asn Asn  Pro Ile Ala Lys Lys  Glu Pro His Asp Arg  Gly Asn Leu 
    1520                 1525                 1530             


Gly Leu  Glu Gly Ser Cys Thr  Val Pro Pro Asn Val  Ala Thr Gly 
    1535                 1540                 1545             


Arg Leu  Pro Gly Ala Ser Leu  Leu Leu Glu Pro Ser  Ser Leu Thr 
    1550                 1555                 1560             


Ala Asn  Met Lys Glu Val Pro  Leu Phe Arg Leu Arg  His Phe Pro 
    1565                 1570                 1575             


Cys Gly  Asn Val Asn Tyr Gly  Tyr Gln Gln Gln Gly  Leu Pro Leu 
    1580                 1585                 1590             


Glu Ala  Ala Thr Ala Pro Gly  Ala Gly His Tyr Glu  Asp Thr Ile 
    1595                 1600                 1605             


Leu Lys  Ser Lys Asn Ser Met  Asn Gln Pro Gly Pro  
    1610                 1615                 1620 


<210>  3014
<211>  439
<212>  PRT
<213>  Homo sapiens

<400>  3014

Met Asp Pro Leu Ser Glu Leu Gln Asp Asp Leu Thr Leu Asp Asp Thr 
1               5                   10                  15      


Ser Glu Ala Leu Asn Gln Leu Lys Leu Ala Ser Ile Asp Glu Lys Asn 
            20                  25                  30          


Trp Pro Ser Asp Glu Met Pro Asp Phe Pro Lys Ser Asp Asp Ser Lys 
        35                  40                  45              


Ser Ser Ser Pro Glu Leu Val Thr His Leu Lys Trp Asp Asp Pro Tyr 
    50                  55                  60                  


Tyr Asp Ile Ala Arg His Gln Ile Val Glu Val Ala Gly Asp Asp Lys 
65                  70                  75                  80  


Tyr Gly Arg Lys Ile Ile Val Phe Ser Ala Cys Arg Met Pro Pro Ser 
                85                  90                  95      


His Gln Leu Asp His Ser Lys Leu Leu Gly Tyr Leu Lys His Thr Leu 
            100                 105                 110         


Asp Gln Tyr Val Glu Ser Asp Tyr Thr Leu Leu Tyr Leu His His Gly 
        115                 120                 125             


Leu Thr Ser Asp Asn Lys Pro Ser Leu Ser Trp Leu Arg Asp Ala Tyr 
    130                 135                 140                 


Arg Glu Phe Asp Arg Lys Tyr Lys Lys Asn Ile Lys Ala Leu Tyr Ile 
145                 150                 155                 160 


Val His Pro Thr Met Phe Ile Lys Thr Leu Leu Ile Leu Phe Lys Pro 
                165                 170                 175     


Leu Ile Ser Phe Lys Phe Gly Gln Lys Ile Phe Tyr Val Asn Tyr Leu 
            180                 185                 190         


Ser Glu Leu Ser Glu His Val Lys Leu Glu Gln Leu Gly Ile Pro Arg 
        195                 200                 205             


Gln Val Leu Lys Tyr Asp Asp Phe Leu Lys Ser Thr Gln Lys Ser Pro 
    210                 215                 220                 


Ala Thr Ala Pro Lys Pro Met Pro Pro Arg Pro Pro Leu Pro Asn Gln 
225                 230                 235                 240 


Gln Phe Gly Val Ser Leu Gln His Leu Gln Glu Lys Asn Pro Glu Gln 
                245                 250                 255     


Glu Pro Ile Pro Ile Val Leu Arg Glu Thr Val Ala Tyr Leu Gln Ala 
            260                 265                 270         


His Ala Leu Thr Thr Glu Gly Ile Phe Arg Arg Ser Ala Asn Thr Gln 
        275                 280                 285             


Val Val Arg Glu Val Gln Gln Lys Tyr Asn Met Gly Leu Pro Val Asp 
    290                 295                 300                 


Phe Asp Gln Tyr Asn Glu Leu His Leu Pro Ala Val Ile Leu Lys Thr 
305                 310                 315                 320 


Phe Leu Arg Glu Leu Pro Glu Pro Leu Leu Thr Phe Asp Leu Tyr Pro 
                325                 330                 335     


His Val Val Gly Phe Leu Asn Ile Asp Glu Ser Gln Arg Val Pro Ala 
            340                 345                 350         


Thr Leu Gln Val Leu Gln Thr Leu Pro Glu Glu Asn Tyr Gln Val Leu 
        355                 360                 365             


Arg Phe Leu Thr Ala Phe Leu Val Gln Ile Ser Ala His Ser Asp Gln 
    370                 375                 380                 


Asn Lys Met Thr Asn Thr Asn Leu Ala Val Val Phe Gly Pro Asn Leu 
385                 390                 395                 400 


Leu Trp Ala Lys Asp Ala Ala Ile Thr Leu Lys Ala Ile Asn Pro Ile 
                405                 410                 415     


Asn Thr Phe Thr Lys Phe Leu Leu Asp His Gln Gly Glu Leu Phe Pro 
            420                 425                 430         


Ser Pro Asp Pro Ser Gly Leu 
        435                 


<210>  3015
<211>  758
<212>  PRT
<213>  Homo sapiens

<400>  3015

Met Ala Gln Arg Lys Asn Ala Lys Ser Ser Gly Asn Ser Ser Ser Ser 
1               5                   10                  15      


Gly Ser Gly Ser Gly Ser Thr Ser Ala Gly Ser Ser Ser Pro Gly Ala 
            20                  25                  30          


Arg Arg Glu Thr Lys His Gly Gly His Lys Asn Gly Arg Lys Gly Gly 
        35                  40                  45              


Leu Ser Gly Thr Ser Phe Phe Thr Trp Phe Met Val Ile Ala Leu Leu 
    50                  55                  60                  


Gly Val Trp Thr Ser Val Ala Val Val Trp Phe Asp Leu Val Asp Tyr 
65                  70                  75                  80  


Glu Glu Val Leu Gly Lys Leu Gly Ile Tyr Asp Ala Asp Gly Asp Gly 
                85                  90                  95      


Asp Phe Asp Val Asp Asp Ala Lys Val Leu Leu Gly Leu Lys Glu Arg 
            100                 105                 110         


Ser Thr Ser Glu Pro Ala Val Pro Pro Glu Glu Ala Glu Pro His Thr 
        115                 120                 125             


Glu Pro Glu Glu Gln Val Pro Val Glu Ala Glu Pro Gln Asn Ile Glu 
    130                 135                 140                 


Asp Glu Ala Lys Glu Gln Ile Gln Ser Leu Leu His Glu Met Val His 
145                 150                 155                 160 


Ala Glu His Val Glu Gly Glu Asp Leu Gln Gln Glu Asp Gly Pro Thr 
                165                 170                 175     


Gly Glu Pro Gln Gln Glu Asp Asp Glu Phe Leu Met Ala Thr Asp Val 
            180                 185                 190         


Asp Asp Arg Phe Glu Thr Leu Glu Pro Glu Val Ser His Glu Glu Thr 
        195                 200                 205             


Glu His Ser Tyr His Val Glu Glu Thr Val Ser Gln Asp Cys Asn Gln 
    210                 215                 220                 


Asp Met Glu Glu Met Met Ser Glu Gln Glu Asn Pro Asp Ser Ser Glu 
225                 230                 235                 240 


Pro Val Val Glu Asp Glu Arg Leu His His Asp Thr Asp Asp Val Thr 
                245                 250                 255     


Tyr Gln Val Tyr Glu Glu Gln Ala Val Tyr Glu Pro Leu Glu Asn Glu 
            260                 265                 270         


Gly Ile Glu Ile Thr Glu Val Thr Ala Pro Pro Glu Asp Asn Pro Val 
        275                 280                 285             


Glu Asp Ser Gln Val Ile Val Glu Glu Val Ser Ile Phe Pro Val Glu 
    290                 295                 300                 


Glu Gln Gln Glu Val Pro Pro Glu Thr Asn Arg Lys Thr Asp Asp Pro 
305                 310                 315                 320 


Glu Gln Lys Ala Lys Val Lys Lys Lys Lys Pro Lys Leu Leu Asn Lys 
                325                 330                 335     


Phe Asp Lys Thr Ile Lys Ala Glu Leu Asp Ala Ala Glu Lys Leu Arg 
            340                 345                 350         


Lys Arg Gly Lys Ile Glu Glu Ala Val Asn Ala Phe Lys Glu Leu Val 
        355                 360                 365             


Arg Lys Tyr Pro Gln Ser Pro Arg Ala Arg Tyr Gly Lys Ala Gln Cys 
    370                 375                 380                 


Glu Asp Asp Leu Ala Glu Lys Arg Arg Ser Asn Glu Val Leu Arg Gly 
385                 390                 395                 400 


Ala Ile Glu Thr Tyr Gln Glu Val Ala Ser Leu Pro Asp Val Pro Ala 
                405                 410                 415     


Asp Leu Leu Lys Leu Ser Leu Lys Arg Arg Ser Asp Arg Gln Gln Phe 
            420                 425                 430         


Leu Gly His Met Arg Gly Ser Leu Leu Thr Leu Gln Arg Leu Val Gln 
        435                 440                 445             


Leu Phe Pro Asn Asp Thr Ser Leu Lys Asn Asp Leu Gly Val Gly Tyr 
    450                 455                 460                 


Leu Leu Ile Gly Asp Asn Asp Asn Ala Lys Lys Val Tyr Glu Glu Val 
465                 470                 475                 480 


Leu Ser Val Thr Pro Asn Asp Gly Phe Ala Lys Val His Tyr Gly Phe 
                485                 490                 495     


Ile Leu Lys Ala Gln Asn Lys Ile Ala Glu Ser Ile Pro Tyr Leu Lys 
            500                 505                 510         


Glu Gly Ile Glu Ser Gly Asp Pro Gly Thr Asp Asp Gly Arg Phe Tyr 
        515                 520                 525             


Phe His Leu Gly Asp Ala Met Gln Arg Val Gly Asn Lys Glu Ala Tyr 
    530                 535                 540                 


Lys Trp Tyr Glu Leu Gly His Lys Arg Gly His Phe Ala Ser Val Trp 
545                 550                 555                 560 


Gln Arg Ser Leu Tyr Asn Val Asn Gly Leu Lys Ala Gln Pro Trp Trp 
                565                 570                 575     


Thr Pro Lys Glu Thr Gly Tyr Thr Glu Leu Val Lys Ser Leu Glu Arg 
            580                 585                 590         


Asn Trp Lys Leu Ile Arg Asp Glu Gly Leu Ala Val Met Asp Lys Ala 
        595                 600                 605             


Lys Gly Leu Phe Leu Pro Glu Asp Glu Asn Leu Arg Glu Lys Gly Asp 
    610                 615                 620                 


Trp Ser Gln Phe Thr Leu Trp Gln Gln Gly Arg Arg Asn Glu Asn Ala 
625                 630                 635                 640 


Cys Lys Gly Ala Pro Lys Thr Cys Thr Leu Leu Glu Lys Phe Pro Glu 
                645                 650                 655     


Thr Thr Gly Cys Arg Arg Gly Gln Ile Lys Tyr Ser Ile Met His Pro 
            660                 665                 670         


Gly Thr His Val Trp Pro His Thr Gly Pro Thr Asn Cys Arg Leu Arg 
        675                 680                 685             


Met His Leu Gly Leu Val Ile Pro Lys Glu Gly Cys Lys Ile Arg Cys 
    690                 695                 700                 


Ala Asn Glu Thr Lys Thr Trp Glu Glu Gly Lys Val Leu Ile Phe Asp 
705                 710                 715                 720 


Asp Ser Phe Glu His Glu Val Trp Gln Asp Ala Ser Ser Phe Arg Leu 
                725                 730                 735     


Ile Phe Ile Val Asp Val Trp His Pro Glu Leu Thr Pro Gln Gln Arg 
            740                 745                 750         


Arg Ser Leu Pro Ala Ile 
        755             


<210>  3016
<211>  1294
<212>  PRT
<213>  Homo sapiens

<400>  3016

Met Ala Leu Ala Gly Leu Cys Ala Leu Leu Ala Cys Cys Trp Gly Pro 
1               5                   10                  15      


Ala Ala Val Leu Ala Thr Ala Ala Gly Asp Val Asp Pro Ser Lys Glu 
            20                  25                  30          


Leu Glu Cys Lys Leu Lys Ser Ile Thr Val Ser Ala Leu Pro Phe Leu 
        35                  40                  45              


Arg Glu Asn Asp Leu Ser Ile Met His Ser Pro Ser Ala Ser Glu Pro 
    50                  55                  60                  


Lys Leu Leu Phe Ser Val Arg Asn Asp Phe Pro Gly Glu Met Val Val 
65                  70                  75                  80  


Val Asp Asp Leu Glu Asn Thr Glu Leu Pro Tyr Phe Val Leu Glu Ile 
                85                  90                  95      


Ser Gly Asn Thr Glu Asp Ile Pro Leu Val Arg Trp Arg Gln Gln Trp 
            100                 105                 110         


Leu Glu Asn Gly Thr Leu Leu Phe His Ile His His Gln Asp Gly Ala 
        115                 120                 125             


Pro Ser Leu Pro Gly Gln Asp Pro Thr Glu Glu Pro Gln His Glu Ser 
    130                 135                 140                 


Ala Glu Glu Glu Leu Arg Ile Leu His Ile Ser Val Met Gly Gly Met 
145                 150                 155                 160 


Ile Ala Leu Leu Leu Ser Ile Leu Cys Leu Val Met Ile Leu Tyr Thr 
                165                 170                 175     


Arg Arg Arg Trp Cys Lys Arg Arg Arg Val Pro Gln Pro Gln Lys Ser 
            180                 185                 190         


Ala Ser Ala Glu Ala Ala Asn Glu Ile His Tyr Ile Pro Ser Val Leu 
        195                 200                 205             


Ile Gly Gly His Gly Arg Glu Ser Leu Arg Asn Ala Arg Val Gln Gly 
    210                 215                 220                 


His Asn Ser Ser Gly Thr Leu Ser Ile Arg Glu Thr Pro Ile Leu Asp 
225                 230                 235                 240 


Gly Tyr Glu Tyr Asp Ile Thr Asp Leu Arg His His Leu Gln Arg Glu 
                245                 250                 255     


Cys Met Asn Gly Gly Glu Asp Phe Ala Ser Gln Val Thr Arg Thr Leu 
            260                 265                 270         


Asp Ser Leu Gln Gly Cys Asn Glu Lys Ser Gly Met Asp Leu Thr Pro 
        275                 280                 285             


Gly Ser Asp Asn Ala Lys Leu Ser Leu Met Asn Lys Tyr Lys Asp Asn 
    290                 295                 300                 


Ile Ile Ala Thr Ser Pro Val Asp Ser Asn His Gln Gln Ala Thr Leu 
305                 310                 315                 320 


Leu Ser His Thr Ser Ser Ser Gln Arg Lys Arg Ile Asn Asn Lys Ala 
                325                 330                 335     


Arg Ala Gly Ser Ala Phe Leu Asn Pro Glu Gly Asp Ser Gly Thr Glu 
            340                 345                 350         


Ala Glu Asn Asp Pro Gln Leu Thr Phe Tyr Thr Asp Pro Ser Arg Ser 
        355                 360                 365             


Arg Arg Arg Ser Arg Val Gly Ser Pro Arg Ser Pro Val Asn Lys Thr 
    370                 375                 380                 


Thr Leu Thr Leu Ile Ser Ile Thr Ser Cys Val Ile Gly Leu Val Cys 
385                 390                 395                 400 


Ser Ser His Val Asn Cys Pro Leu Val Val Lys Ile Thr Leu His Val 
                405                 410                 415     


Pro Glu His Leu Ile Ala Asp Gly Ser Arg Phe Ile Leu Leu Glu Gly 
            420                 425                 430         


Ser Gln Leu Asp Ala Ser Asp Trp Leu Asn Pro Ala Gln Val Val Leu 
        435                 440                 445             


Phe Ser Gln Gln Asn Ser Ser Gly Pro Trp Ala Met Asp Leu Cys Ala 
    450                 455                 460                 


Arg Arg Leu Leu Asp Pro Cys Glu His Gln Cys Asp Pro Glu Thr Gly 
465                 470                 475                 480 


Glu Cys Leu Cys Tyr Glu Gly Tyr Met Lys Asp Pro Val His Lys His 
                485                 490                 495     


Leu Cys Ile Arg Asn Glu Trp Gly Thr Asn Gln Gly Pro Trp Pro Tyr 
            500                 505                 510         


Thr Ile Phe Gln Arg Gly Phe Asp Leu Val Leu Gly Glu Gln Pro Ser 
        515                 520                 525             


Asp Lys Ile Phe Arg Phe Thr Tyr Thr Leu Gly Glu Gly Met Trp Leu 
    530                 535                 540                 


Pro Leu Ser Lys Ser Phe Val Ile Pro Pro Ala Glu Leu Ala Ile Asn 
545                 550                 555                 560 


Pro Ser Ala Lys Cys Lys Thr Asp Met Thr Val Met Glu Asp Ala Val 
                565                 570                 575     


Glu Val Arg Glu Glu Leu Met Thr Ser Ser Ser Phe Asp Ser Leu Glu 
            580                 585                 590         


Val Leu Leu Asp Ser Phe Gly Pro Val Arg Asp Cys Ser Lys Asp Asn 
        595                 600                 605             


Gly Gly Cys Ser Lys Asn Phe Arg Cys Ile Ser Asp Arg Lys Leu Asp 
    610                 615                 620                 


Ser Thr Gly Cys Val Cys Pro Ser Gly Leu Ser Pro Met Lys Asp Ser 
625                 630                 635                 640 


Ser Gly Cys Tyr Asp Arg His Ile Gly Val Asp Cys Ser Asp Gly Phe 
                645                 650                 655     


Asn Gly Gly Cys Glu Gln Leu Cys Leu Gln Gln Met Ala Pro Phe Pro 
            660                 665                 670         


Asp Asp Pro Thr Leu Tyr Asn Ile Leu Met Phe Cys Gly Cys Ile Glu 
        675                 680                 685             


Asp Tyr Lys Leu Gly Val Asp Gly Arg Ser Cys Gln Leu Ile Thr Glu 
    690                 695                 700                 


Thr Cys Pro Glu Gly Ser Asp Cys Gly Glu Ser Arg Glu Leu Pro Met 
705                 710                 715                 720 


Asn Gln Thr Leu Phe Gly Glu Met Phe Phe Gly Tyr Asn Asn His Ser 
                725                 730                 735     


Lys Glu Val Ala Ala Gly Gln Val Leu Lys Gly Thr Phe Arg Gln Asn 
            740                 745                 750         


Asn Phe Ala Arg Gly Leu Asp Gln Gln Leu Pro Asp Gly Leu Val Val 
        755                 760                 765             


Ala Thr Val Pro Leu Glu Asn Gln Cys Leu Glu Glu Ile Ser Glu Pro 
    770                 775                 780                 


Thr Pro Asp Pro Asp Phe Leu Thr Gly Met Val Asn Phe Ser Glu Val 
785                 790                 795                 800 


Ser Gly Tyr Pro Val Leu Gln His Trp Lys Val Arg Ser Val Met Tyr 
                805                 810                 815     


His Ile Lys Leu Asn Gln Val Ala Ile Ser Gln Ala Leu Ser Asn Ala 
            820                 825                 830         


Leu His Ser Leu Asp Gly Ala Thr Ser Arg Ala Asp Phe Val Ala Leu 
        835                 840                 845             


Leu Asp Gln Phe Gly Asn His Tyr Ile Gln Glu Ala Ile Tyr Gly Phe 
    850                 855                 860                 


Glu Glu Ser Cys Ser Ile Trp Tyr Pro Asn Lys Gln Val Gln Arg Arg 
865                 870                 875                 880 


Leu Trp Leu Glu Tyr Glu Asp Ile Ser Lys Gly Asn Ser Pro Ser Asp 
                885                 890                 895     


Glu Ser Glu Glu Arg Glu Arg Asp Pro Lys Val Leu Thr Phe Pro Glu 
            900                 905                 910         


Tyr Ile Thr Ser Leu Ser Asp Ser Gly Thr Lys His Met Ala Ala Gly 
        915                 920                 925             


Val Arg Met Glu Cys His Ser Lys Gly Arg Cys Pro Ser Ser Cys Pro 
    930                 935                 940                 


Leu Cys His Val Thr Ser Ser Pro Asp Thr Pro Ala Glu Pro Val Leu 
945                 950                 955                 960 


Leu Glu Val Thr Lys Ala Ala Pro Ile Tyr Glu Leu Val Thr Asn Asn 
                965                 970                 975     


Gln Thr Gln Arg Leu Leu Gln Glu Ala Thr Met Ser Ser Leu Trp Cys 
            980                 985                 990         


Ser Gly Thr Gly Asp Val Ile Glu  Asp Trp Cys Arg Cys  Asp Ser Thr 
        995                 1000                 1005             


Ala Phe  Gly Ala Asp Gly Leu  Pro Thr Cys Ala Pro  Leu Pro Gln 
    1010                 1015                 1020             


Pro Val  Leu Arg Leu Ser Thr  Val His Glu Pro Ser  Ser Thr Leu 
    1025                 1030                 1035             


Val Val  Leu Glu Trp Glu His  Ser Glu Pro Pro Ile  Gly Val Gln 
    1040                 1045                 1050             


Ile Val  Asp Tyr Leu Leu Arg  Gln Glu Lys Val Thr  Asp Arg Met 
    1055                 1060                 1065             


Asp His  Ser Lys Val Glu Thr  Glu Thr Val Leu Ser  Phe Val Asp 
    1070                 1075                 1080             


Asp Ile  Ile Ser Gly Ala Lys  Ser Pro Cys Ala Met  Pro Ser Gln 
    1085                 1090                 1095             


Val Pro  Asp Lys Gln Leu Thr  Thr Ile Ser Leu Ile  Ile Arg Cys 
    1100                 1105                 1110             


Leu Glu  Pro Asp Thr Ile Tyr  Met Phe Thr Leu Trp  Gly Val Asp 
    1115                 1120                 1125             


Asn Thr  Gly Arg Arg Ser Arg  Pro Ser Asp Val Ile  Val Lys Thr 
    1130                 1135                 1140             


Pro Cys  Pro Val Val Asp Asp  Val Lys Ala Gln Glu  Ile Ala Asp 
    1145                 1150                 1155             


Lys Ile  Tyr Asn Leu Phe Asn  Gly Tyr Thr Ser Gly  Lys Glu Gln 
    1160                 1165                 1170             


Gln Thr  Ala Tyr Asn Thr Leu  Leu Asp Leu Gly Ser  Pro Thr Leu 
    1175                 1180                 1185             


His Arg  Val Leu Tyr His Tyr  Asn Gln His Tyr Glu  Ser Phe Gly 
    1190                 1195                 1200             


Glu Phe  Thr Trp Arg Cys Glu  Asp Glu Leu Gly Pro  Arg Lys Ala 
    1205                 1210                 1215             


Gly Leu  Ile Leu Ser Gln Leu  Gly Asp Leu Ser Ser  Trp Cys Asn 
    1220                 1225                 1230             


Gly Leu  Leu Gln Glu Pro Lys  Ile Ser Leu Arg Arg  Ser Ser Leu 
    1235                 1240                 1245             


Lys Tyr  Leu Gly Cys Arg Tyr  Ser Glu Ile Lys Pro  Tyr Gly Leu 
    1250                 1255                 1260             


Asp Trp  Ala Glu Leu Ser Arg  Asp Leu Arg Lys Thr  Cys Glu Glu 
    1265                 1270                 1275             


Gln Thr  Leu Ser Ile Pro Tyr  Asn Asp Tyr Gly Asp  Ser Lys Glu 
    1280                 1285                 1290             


Ile 
    


<210>  3017
<211>  994
<212>  PRT
<213>  Homo sapiens

<400>  3017

Met Glu Ala Ala His Ala Lys Thr Thr Glu Glu Cys Leu Ala Tyr Phe 
1               5                   10                  15      


Gly Val Ser Glu Thr Thr Gly Leu Thr Pro Asp Gln Val Lys Arg Asn 
            20                  25                  30          


Leu Glu Lys Tyr Gly Leu Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              


Leu Trp Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Ile Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Ala Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Arg Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Ile Arg Ile Leu Ala Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Glu 
            180                 185                 190         


Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Leu Gly Ile Val Ala 
    210                 215                 220                 


Thr Thr Gly Val Gly Thr Glu Ile Gly Lys Ile Arg Asp Gln Met Ala 
225                 230                 235                 240 


Ala Thr Glu Gln Asp Lys Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Val Ala Val Trp 
            260                 265                 270         


Leu Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             


Phe Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Lys Met Phe Ile 
        355                 360                 365             


Ile Asp Lys Val Asp Gly Asp Ile Cys Leu Leu Asn Glu Phe Ser Ile 
    370                 375                 380                 


Thr Gly Ser Thr Tyr Ala Pro Glu Gly Glu Val Leu Lys Asn Asp Lys 
385                 390                 395                 400 


Pro Val Arg Pro Gly Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ser Leu Asp Phe Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Thr Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asn Thr Asp Val Arg Ser Leu Ser Lys 
    450                 455                 460                 


Val Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Arg Gln Leu Met Lys 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Ser Pro Ala Lys Ser Ser Arg Ala Ala Val Gly Asn Lys Met 
            500                 505                 510         


Phe Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Asn Tyr Val 
        515                 520                 525             


Arg Val Gly Thr Thr Arg Val Pro Leu Thr Gly Pro Val Lys Glu Lys 
    530                 535                 540                 


Ile Met Ala Val Ile Lys Glu Trp Gly Thr Gly Arg Asp Thr Leu Arg 
545                 550                 555                 560 


Cys Leu Ala Leu Ala Thr Arg Asp Thr Pro Pro Lys Arg Glu Glu Met 
                565                 570                 575     


Val Leu Asp Asp Ser Ala Arg Phe Leu Glu Tyr Glu Thr Asp Leu Thr 
            580                 585                 590         


Phe Val Gly Val Val Gly Met Leu Asp Pro Pro Arg Lys Glu Val Thr 
        595                 600                 605             


Gly Ser Ile Gln Leu Cys Arg Asp Ala Gly Ile Arg Val Ile Met Ile 
    610                 615                 620                 


Thr Gly Asp Asn Lys Gly Thr Ala Ile Ala Ile Cys Arg Arg Ile Gly 
625                 630                 635                 640 


Ile Phe Gly Glu Asn Glu Glu Val Ala Asp Arg Ala Tyr Thr Gly Arg 
                645                 650                 655     


Glu Phe Asp Asp Leu Pro Leu Ala Glu Gln Arg Glu Ala Cys Arg Arg 
            660                 665                 670         


Ala Cys Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val 
        675                 680                 685             


Glu Tyr Leu Gln Ser Tyr Asp Glu Ile Thr Ala Met Thr Gly Asp Gly 
    690                 695                 700                 


Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met 
705                 710                 715                 720 


Gly Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala 
                725                 730                 735     


Asp Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala 
            740                 745                 750         


Ile Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn 
        755                 760                 765             


Val Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Leu Pro 
    770                 775                 780                 


Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp 
785                 790                 795                 800 


Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile 
                805                 810                 815     


Met Asp Arg Pro Pro Arg Ser Pro Lys Glu Pro Leu Ile Ser Gly Trp 
            820                 825                 830         


Leu Phe Phe Arg Tyr Met Ala Ile Gly Gly Tyr Val Gly Ala Ala Thr 
        835                 840                 845             


Val Gly Ala Ala Ala Trp Trp Phe Leu Tyr Ala Glu Asp Gly Pro His 
    850                 855                 860                 


Val Asn Tyr Ser Gln Leu Thr His Phe Met Gln Cys Thr Glu Asp Asn 
865                 870                 875                 880 


Thr His Phe Glu Gly Ile Asp Cys Glu Val Phe Glu Ala Pro Glu Pro 
                885                 890                 895     


Met Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala 
            900                 905                 910         


Leu Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp 
        915                 920                 925             


Val Asn Ile Trp Leu Leu Gly Ser Ile Cys Leu Ser Met Ser Leu His 
    930                 935                 940                 


Phe Leu Ile Leu Tyr Val Asp Pro Leu Pro Met Ile Phe Lys Leu Arg 
945                 950                 955                 960 


Ala Leu Asp Leu Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro 
                965                 970                 975     


Val Ile Gly Leu Asp Glu Ile Leu Lys Phe Val Ala Arg Asn Tyr Leu 
            980                 985                 990         


Glu Gly 
        


<210>  3018
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  3018

Met Asp Gly Ser Gly Glu Gln Pro Arg Gly Gly Gly Pro Thr Ser Ser 
1               5                   10                  15      


Glu Gln Ile Met Lys Thr Gly Ala Leu Leu Leu Gln Gly Phe Ile Gln 
            20                  25                  30          


Asp Arg Ala Gly Arg Met Gly Gly Glu Ala Pro Glu Leu Ala Leu Asp 
        35                  40                  45              


Pro Val Pro Gln Asp Ala Ser Thr Lys Lys Leu Ser Glu Cys Leu Lys 
    50                  55                  60                  


Arg Ile Gly Asp Glu Leu Asp Ser Asn Met Glu Leu Gln Arg Met Ile 
65                  70                  75                  80  


Ala Ala Val Asp Thr Asp Ser Pro Arg Glu Val Phe Phe Arg Val Ala 
                85                  90                  95      


Ala Asp Met Phe Ser Asp Gly Asn Phe Asn Trp Gly Arg Val Val Ala 
            100                 105                 110         


Leu Phe Tyr Phe Ala Ser Lys Leu Val Leu Lys Ala Leu Cys Thr Lys 
        115                 120                 125             


Val Pro Glu Leu Ile Arg Thr Ile Met Gly Trp Thr Leu Asp Phe Leu 
    130                 135                 140                 


Arg Glu Arg Leu Leu Gly Trp Ile Gln Asp Gln Gly Gly Trp Val Arg 
145                 150                 155                 160 


Leu Leu Lys Pro Pro His Pro His His Arg Ala Leu Thr Thr Ala Pro 
                165                 170                 175     


Ala Pro Pro Ser Leu Pro Pro Ala Thr Pro Leu Gly Pro Trp Ala Phe 
            180                 185                 190         


Trp Ser Arg Ser Gln Trp Cys Pro Leu Pro Ile Phe Arg Ser Ser Asp 
        195                 200                 205             


Val Val Tyr Asn Ala Phe Ser Leu Arg Val 
    210                 215             


<210>  3019
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  3019

Met Pro Leu Ser Asp Phe Ile Leu Ala Leu Lys Asp Asn Pro Tyr Phe 
1               5                   10                  15      


Gly Ala Gly Phe Gly Leu Val Gly Val Gly Thr Ala Leu Ala Leu Ala 
            20                  25                  30          


Arg Lys Gly Val Gln Leu Gly Leu Val Ala Phe Arg Arg His Tyr Met 
        35                  40                  45              


Ile Thr Leu Glu Val Pro Ala Arg Asp Arg Ser Tyr Ala Trp Leu Leu 
    50                  55                  60                  


Ser Trp Leu Thr Arg His Ser Thr Arg Thr Gln His Leu Ser Val Glu 
65                  70                  75                  80  


Thr Ser Tyr Leu Gln His Glu Ser Gly Arg Ile Ser Thr Lys Phe Glu 
                85                  90                  95      


Phe Val Pro Ser Pro Gly Asn His Phe Ile Trp Tyr Arg Gly Lys Trp 
            100                 105                 110         


Ile Arg Val Glu Arg Ser Arg Glu Met Gln Met Ile Asp Leu Gln Thr 
        115                 120                 125             


Gly Thr Pro Trp Glu Ser Val Thr Phe Thr Ala Leu Gly Thr Asp Arg 
    130                 135                 140                 


Lys Val Phe Phe Asn Ile Leu Glu Glu Ala Arg Glu Leu Ala Leu Gln 
145                 150                 155                 160 


Gln Glu Glu Gly Lys Thr Val Met Tyr Thr Ala Val Gly Ser Glu Trp 
                165                 170                 175     


Arg Pro Phe Gly Tyr Pro Arg Arg Arg Arg Pro Leu Asn Ser Val Val 
            180                 185                 190         


Leu Gln Gln Gly Leu Ala Asp Arg Ile Val Arg Asp Val Gln Glu Phe 
        195                 200                 205             


Ile Asp Asn Pro Lys Trp Tyr Thr Asp Arg Gly Ile Pro Tyr Arg Arg 
    210                 215                 220                 


Gly Tyr Leu Leu Tyr Gly Pro Pro Gly Cys Gly Lys Ser Ser Phe Ile 
225                 230                 235                 240 


Thr Ala Leu Ala Gly Glu Leu Glu His Ser Ile Cys Leu Leu Ser Leu 
                245                 250                 255     


Thr Asp Ser Ser Leu Ser Asp Asp Arg Leu Asn His Leu Leu Ser Val 
            260                 265                 270         


Ala Pro Gln Gln Ser Leu Val Leu Leu Glu Asp Val Asp Ala Ala Phe 
        275                 280                 285             


Leu Ser Arg Asp Leu Ala Val Glu Asn Pro Val Lys Tyr Gln Gly Leu 
    290                 295                 300                 


Gly Arg Leu Thr Phe Ser Gly Leu Leu Asn Ala Leu Asp Gly Val Ala 
305                 310                 315                 320 


Ser Thr Glu Ala Arg Ile Val Phe Met Thr Thr Asn His Val Asp Arg 
                325                 330                 335     


Leu Asp Pro Ala Leu Ile Arg Pro Gly Arg Val Asp Leu Lys Glu Tyr 
            340                 345                 350         


Val Gly Tyr Cys Ser His Trp Gln Leu Thr Gln Met Phe Gln Arg Phe 
        355                 360                 365             


Tyr Pro Gly Gln Ala Pro Ser Leu Ala Glu Asn Phe Ala Glu His Val 
    370                 375                 380                 


Leu Arg Ala Thr Asn Gln Ile Ser Pro Ala Gln Val Gln Gly Tyr Phe 
385                 390                 395                 400 


Met Leu Tyr Lys Asn Asp Pro Val Gly Ala Ile His Asn Ala Glu Ser 
                405                 410                 415     


Leu Arg Arg 
            


<210>  3020
<211>  532
<212>  PRT
<213>  Homo sapiens

<400>  3020

Met Pro Gln Leu Tyr Ile Tyr Ile Arg Leu Leu Gly Ala Tyr Leu Phe 
1               5                   10                  15      


Ile Ile Ser Arg Val Gln Gly Gln Asn Leu Asp Ser Met Leu His Gly 
            20                  25                  30          


Thr Gly Met Lys Ser Asp Ser Asp Gln Lys Lys Ser Glu Asn Gly Val 
        35                  40                  45              


Thr Leu Ala Pro Glu Asp Thr Leu Pro Phe Leu Lys Cys Tyr Cys Ser 
    50                  55                  60                  


Gly His Cys Pro Asp Asp Ala Ile Asn Asn Thr Cys Ile Thr Asn Gly 
65                  70                  75                  80  


His Cys Phe Ala Ile Ile Glu Glu Asp Asp Gln Gly Glu Thr Thr Leu 
                85                  90                  95      


Ala Ser Gly Cys Met Lys Tyr Glu Gly Ser Asp Phe Gln Cys Lys Asp 
            100                 105                 110         


Ser Pro Lys Ala Gln Leu Arg Arg Thr Ile Glu Cys Cys Arg Thr Asn 
        115                 120                 125             


Leu Cys Asn Gln Tyr Leu Gln Pro Thr Leu Pro Pro Val Val Ile Gly 
    130                 135                 140                 


Pro Phe Phe Asp Gly Ser Ile Arg Trp Leu Val Leu Leu Ile Ser Met 
145                 150                 155                 160 


Ala Val Cys Ile Ile Ala Met Ile Ile Phe Ser Ser Cys Phe Cys Tyr 
                165                 170                 175     


Lys His Tyr Cys Lys Ser Ile Ser Ser Arg Arg Arg Tyr Asn Arg Asp 
            180                 185                 190         


Leu Glu Gln Asp Glu Ala Phe Ile Pro Val Gly Glu Ser Leu Lys Asp 
        195                 200                 205             


Leu Ile Asp Gln Ser Gln Ser Ser Gly Ser Gly Ser Gly Leu Pro Leu 
    210                 215                 220                 


Leu Val Gln Arg Thr Ile Ala Lys Gln Ile Gln Met Val Arg Gln Val 
225                 230                 235                 240 


Gly Lys Gly Arg Tyr Gly Glu Val Trp Met Gly Lys Trp Arg Gly Glu 
                245                 250                 255     


Lys Val Ala Val Lys Val Phe Phe Thr Thr Glu Glu Ala Ser Trp Phe 
            260                 265                 270         


Arg Glu Thr Glu Ile Tyr Gln Thr Val Leu Met Arg His Glu Asn Ile 
        275                 280                 285             


Leu Gly Phe Ile Ala Ala Asp Ile Lys Gly Thr Gly Ser Trp Thr Gln 
    290                 295                 300                 


Leu Tyr Leu Ile Thr Asp Tyr His Glu Asn Gly Ser Leu Tyr Asp Phe 
305                 310                 315                 320 


Leu Lys Cys Ala Thr Leu Asp Thr Arg Ala Leu Leu Lys Leu Ala Tyr 
                325                 330                 335     


Ser Ala Ala Cys Gly Leu Cys His Leu His Thr Glu Ile Tyr Gly Thr 
            340                 345                 350         


Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser Lys Asn Ile 
        355                 360                 365             


Leu Ile Lys Lys Asn Gly Ser Cys Cys Ile Ala Asp Leu Gly Leu Ala 
    370                 375                 380                 


Val Lys Phe Asn Ser Asp Thr Asn Glu Val Asp Val Pro Leu Asn Thr 
385                 390                 395                 400 


Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Ser 
                405                 410                 415     


Leu Asn Lys Asn His Phe Gln Pro Tyr Ile Met Ala Asp Ile Tyr Ser 
            420                 425                 430         


Phe Gly Leu Ile Ile Trp Glu Met Ala Arg Arg Cys Ile Thr Gly Gly 
        435                 440                 445             


Ile Val Glu Glu Tyr Gln Leu Pro Tyr Tyr Asn Met Val Pro Ser Asp 
    450                 455                 460                 


Pro Ser Tyr Glu Asp Met Arg Glu Val Val Cys Val Lys Arg Leu Arg 
465                 470                 475                 480 


Pro Ile Val Ser Asn Arg Trp Asn Ser Asp Glu Cys Leu Arg Ala Val 
                485                 490                 495     


Leu Lys Leu Met Ser Glu Cys Trp Ala His Asn Pro Ala Ser Arg Leu 
            500                 505                 510         


Thr Ala Leu Arg Ile Lys Lys Thr Leu Ala Lys Met Val Glu Ser Gln 
        515                 520                 525             


Asp Val Lys Ile 
    530         


<210>  3021
<211>  435
<212>  PRT
<213>  Homo sapiens

<400>  3021

Met Leu Cys Gly Phe Gln Glu Asp Ala Thr Pro Pro Pro Pro Pro Arg 
1               5                   10                  15      


Pro Arg Arg Leu His Arg Arg Leu Pro Arg Pro Glu Glu Val Gly Met 
            20                  25                  30          


Leu Ser Leu Pro Pro Gly Leu Leu Thr Val Ser Gly Ser Ala Ala Ala 
        35                  40                  45              


Ala Asp Ala Val Pro Leu Arg Pro Gly Asp Trp Ala Gly Val Ser Thr 
    50                  55                  60                  


Ala Asp Arg Gly Glu Arg Ala Pro Leu Gly Pro Ala Phe Cys Asp Leu 
65                  70                  75                  80  


Ala Val Ser Pro Thr Ser Pro Ala Trp Arg Gly Glu Glu Asp Glu Gly 
                85                  90                  95      


Ala Lys Ala Ser Ser Gly Asp Ile Gly Ser Leu Asp Tyr Gln Glu Phe 
            100                 105                 110         


Val Val Asp Ile Glu Ser Arg Leu Arg Met Glu Gly Val Glu Leu Lys 
        115                 120                 125             


Glu Glu Trp Gln Asp Glu Asp Phe Pro Ile Pro Leu Pro Glu Asp Asp 
    130                 135                 140                 


Ser Ile Glu Ala Asp Ile Leu Ala Ile Thr Gly Pro Glu Asp Gln Pro 
145                 150                 155                 160 


Gly Ser Leu Glu Val Asn Gly Asn Lys Val Arg Lys Lys Leu Met Ala 
                165                 170                 175     


Pro Asp Ile Ser Leu Thr Leu Asp Pro Ser Asp Gly Ser Val Leu Ser 
            180                 185                 190         


Asp Asp Leu Asp Glu Ser Gly Glu Ile Asp Leu Asp Gly Leu Asp Thr 
        195                 200                 205             


Pro Ser Glu Asn Ser Asn Glu Phe Glu Trp Glu Asp Asp Leu Pro Lys 
    210                 215                 220                 


Pro Lys Thr Thr Glu Val Ile Arg Lys Gly Ser Ile Thr Glu Tyr Thr 
225                 230                 235                 240 


Ala Ala Glu Glu Lys Glu Asp Gly Arg Arg Trp Arg Met Phe Arg Ile 
                245                 250                 255     


Gly Glu Gln Asp His Arg Val Asp Met Lys Ala Ile Glu Pro Tyr Lys 
            260                 265                 270         


Lys Val Ile Ser His Gly Gly Tyr Tyr Gly Asp Gly Leu Asn Ala Ile 
        275                 280                 285             


Val Val Phe Ala Val Cys Phe Met Pro Glu Ser Ser Gln Pro Asn Tyr 
    290                 295                 300                 


Arg Tyr Leu Met Asp Asn Leu Phe Lys Tyr Val Ile Gly Thr Leu Glu 
305                 310                 315                 320 


Leu Leu Val Ala Glu Asn Tyr Met Ile Val Tyr Leu Asn Gly Ala Thr 
                325                 330                 335     


Thr Arg Arg Lys Met Pro Ser Leu Gly Trp Leu Arg Lys Cys Tyr Gln 
            340                 345                 350         


Gln Ile Asp Arg Arg Leu Arg Lys Asn Leu Lys Ser Leu Ile Ile Val 
        355                 360                 365             


His Pro Ser Trp Phe Ile Arg Thr Leu Leu Ala Val Thr Arg Pro Phe 
    370                 375                 380                 


Ile Ser Ser Lys Phe Ser Gln Lys Ile Arg Tyr Val Phe Asn Leu Ala 
385                 390                 395                 400 


Glu Leu Ala Glu Leu Val Pro Met Glu Tyr Val Gly Ile Pro Glu Cys 
                405                 410                 415     


Ile Lys Gln Val Asp Gln Glu Leu Asn Gly Lys Gln Asp Glu Pro Lys 
            420                 425                 430         


Asn Glu Gln 
        435 


<210>  3022
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  3022

Met Ser Ser His Leu Val Glu Pro Pro Pro Pro Leu His Asn Asn Asn 
1               5                   10                  15      


Asn Asn Cys Glu Glu Asn Glu Gln Ser Leu Pro Pro Pro Ala Gly Leu 
            20                  25                  30          


Asn Ser Ser Trp Val Glu Leu Pro Met Asn Ser Ser Asn Gly Asn Asp 
        35                  40                  45              


Asn Gly Asn Gly Lys Asn Gly Gly Leu Glu His Val Pro Ser Ser Ser 
    50                  55                  60                  


Ser Ile His Asn Gly Asp Met Glu Lys Ile Leu Leu Asp Ala Gln His 
65                  70                  75                  80  


Glu Ser Gly Gln Ser Ser Ser Arg Gly Ser Ser His Cys Asp Ser Pro 
                85                  90                  95      


Ser Pro Gln Glu Asp Gly Gln Ile Met Phe Asp Val Glu Met His Thr 
            100                 105                 110         


Ser Arg Asp His Ser Ser Gln Ser Glu Glu Glu Val Val Glu Gly Glu 
        115                 120                 125             


Lys Glu Val Glu Ala Leu Lys Lys Ser Ala Asp Trp Val Ser Asp Trp 
    130                 135                 140                 


Ser Ser Arg Pro Glu Asn Ile Pro Pro Lys Glu Phe His Phe Arg His 
145                 150                 155                 160 


Pro Lys Arg Ser Val Ser Leu Ser Met Arg Lys Ser Gly Ala Met Lys 
                165                 170                 175     


Lys Gly Gly Ile Phe Ser Ala Glu Phe Leu Lys Val Phe Ile Pro Ser 
            180                 185                 190         


Leu Phe Leu Ser His Val Leu Ala Leu Gly Leu Gly Ile Tyr Ile Gly 
        195                 200                 205             


Lys Arg Leu Ser Thr Pro Ser Ala Ser Thr Tyr 
    210                 215                 


<210>  3023
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  3023

Met Ala Ala Gln Gly Cys Ala Ala Ser Arg Leu Leu Gln Leu Leu Leu 
1               5                   10                  15      


Gln Leu Leu Leu Leu Leu Leu Leu Leu Ala Ala Gly Gly Ala Arg Ala 
            20                  25                  30          


Arg Trp Arg Gly Glu Gly Thr Ser Ala His Leu Arg Asp Ile Phe Leu 
        35                  40                  45              


Gly Arg Cys Ala Glu Tyr Arg Ala Leu Leu Ser Pro Glu Gln Arg Asn 
    50                  55                  60                  


Lys Asn Cys Thr Ala Ile Trp Glu Ala Phe Lys Val Ala Leu Asp Lys 
65                  70                  75                  80  


Asp Pro Cys Ser Val Leu Pro Ser Asp Tyr Asp Leu Phe Ile Asn Leu 
                85                  90                  95      


Ser Arg His Ser Ile Pro Arg Asp Lys Ser Leu Phe Trp Glu Asn Ser 
            100                 105                 110         


His Leu Leu Val Asn Ser Phe Ala Asp Asn Thr Arg Arg Phe Met Pro 
        115                 120                 125             


Leu Ser Asp Val Leu Tyr Gly Arg Val Ala Asp Phe Leu Ser Trp Cys 
    130                 135                 140                 


Arg Gln Lys Asn Asp Ser Gly Leu Asp Tyr Gln Ser Cys Pro Thr Ser 
145                 150                 155                 160 


Glu Asp Cys Glu Asn Asn Pro Val Asp Ser Phe Trp Lys Arg Ala Ser 
                165                 170                 175     


Ile Gln Tyr Ser Lys Asp Ser Ser Gly Val Ile His Val Met Leu Asn 
            180                 185                 190         


Gly Ser Glu Pro Thr Gly Ala Tyr Pro Ile Lys Gly Phe Phe Ala Asp 
        195                 200                 205             


Tyr Glu Ile Pro Asn Leu Gln Lys Glu Lys Ile Thr Arg Ile Glu Ile 
    210                 215                 220                 


Trp Val Met His Glu Ile Gly Gly Pro Asn Val Glu Ser Cys Gly Glu 
225                 230                 235                 240 


Gly Ser Met Lys Val Leu Glu Lys Arg Leu Lys Asp Met Gly Phe Gln 
                245                 250                 255     


Tyr Ser Cys Ile Asn Asp Tyr Arg Pro Val Lys Leu Leu Gln Cys Val 
            260                 265                 270         


Asp His Ser Thr His Pro Asp Cys Ala Leu Lys Ser Ala Ala Ala Ala 
        275                 280                 285             


Thr Gln Arg Lys Ala Pro Ser Leu Tyr Thr Glu Gln Arg Ala Gly Leu 
    290                 295                 300                 


Ile Ile Pro Leu Phe Leu Val Leu Ala Ser Arg Thr Gln Leu 
305                 310                 315             


<210>  3024
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  3024

Met Ala Ser Thr Ser Tyr Asp Tyr Cys Arg Val Pro Met Glu Asp Gly 
1               5                   10                  15      


Asp Lys Arg Cys Lys Leu Leu Leu Gly Ile Gly Ile Leu Val Leu Leu 
            20                  25                  30          


Ile Ile Val Ile Leu Gly Val Pro Leu Ile Ile Phe Thr Ile Lys Ala 
        35                  40                  45              


Asn Ser Glu Ala Cys Arg Asp Gly Leu Arg Ala Val Met Glu Cys Arg 
    50                  55                  60                  


Asn Val Thr His Leu Leu Gln Gln Glu Leu Thr Glu Ala Gln Lys Gly 
65                  70                  75                  80  


Phe Gln Asp Val Glu Ala Gln Ala Ala Thr Cys Asn His Thr Val Met 
                85                  90                  95      


Ala Leu Met Ala Ser Leu Asp Ala Glu Lys Ala Gln Gly Gln Lys Lys 
            100                 105                 110         


Val Glu Glu Leu Glu Gly Glu Ile Thr Thr Leu Asn His Lys Leu Gln 
        115                 120                 125             


Asp Ala Ser Ala Glu Val Glu Arg Leu Arg Arg Glu Asn Gln Val Leu 
    130                 135                 140                 


Ser Val Arg Ile Ala Asp Lys Lys Tyr Tyr Pro Ser Ser Gln Asp Ser 
145                 150                 155                 160 


Ser Ser Ala Ala Ala Pro Gln Leu Leu Ile Val Leu Leu Gly Leu Ser 
                165                 170                 175     


Ala Leu Leu Gln 
            180 


<210>  3025
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  3025

Met Ser Ser Asp His Leu Asn Asn Ser Thr Leu Lys Glu Ala Gln Phe 
1               5                   10                  15      


Lys Asp Leu Phe Leu Lys Lys Ala Glu Leu Glu Phe Ala Gln Ile Ile 
            20                  25                  30          


Ile Ile Val Val Val Val Thr Val Met Val Val Val Ile Val Cys Leu 
        35                  40                  45              


Leu Asn His Tyr Lys Val Ser Thr Arg Ser Phe Ile Asn Arg Pro Asn 
    50                  55                  60                  


Gln Ser Arg Arg Arg Glu Asp Gly Leu Pro Gln Glu Gly Cys Leu Trp 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Ala Pro Arg Leu Gly Ala Ser Glu Ile Met His 
                85                  90                  95      


Ala Pro Arg Ser Arg Asp Arg Phe Thr Ala Pro Ser Phe Ile Gln Arg 
            100                 105                 110         


Asp Arg Phe Ser Arg Phe Gln Pro Thr Tyr Pro Tyr Val Gln His Glu 
        115                 120                 125             


Ile Asp Leu Pro Pro Thr Ile Ser Leu Ser Asp Gly Glu Glu Pro Pro 
    130                 135                 140                 


Pro Tyr Gln Gly Pro Cys Thr Leu Gln Leu Arg Asp Pro Glu Gln Gln 
145                 150                 155                 160 


Met Glu Leu Asn Arg Glu Ser Val Arg Ala Pro Pro Asn Arg Thr Ile 
                165                 170                 175     


Phe Asp Ser Asp Leu Ile Asp Ile Ala Met Tyr Ser Gly Gly Pro Cys 
            180                 185                 190         


Pro Pro Ser Ser Asn Ser Gly Ile Ser Ala Ser Thr Cys Ser Ser Asn 
        195                 200                 205             


Gly Arg Met Glu Gly Pro Pro Pro Thr Tyr Ser Glu Val Met Gly His 
    210                 215                 220                 


His Pro Gly Ala Ser Phe Leu His His Gln Arg Ser Asn Ala His Arg 
225                 230                 235                 240 


Gly Ser Arg Leu Gln Phe Gln Gln Asn Asn Ala Glu Ser Thr Ile Val 
                245                 250                 255     


Pro Ile Lys Gly Lys Asp Arg Lys Pro Gly Asn Leu Val 
            260                 265                 


<210>  3026
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  3026

Met Ala Pro Gly Val Ala Arg Gly Pro Thr Pro Tyr Trp Arg Leu Arg 
1               5                   10                  15      


Leu Gly Gly Ala Ala Leu Leu Leu Leu Leu Ile Pro Val Ala Ala Ala 
            20                  25                  30          


Gln Glu Pro Pro Gly Ala Ala Cys Ser Gln Asn Thr Asn Lys Thr Cys 
        35                  40                  45              


Glu Glu Cys Leu Lys Asn Val Ser Cys Leu Trp Cys Asn Thr Asn Lys 
    50                  55                  60                  


Ala Cys Leu Asp Tyr Pro Val Thr Ser Val Leu Pro Pro Ala Ser Leu 
65                  70                  75                  80  


Cys Lys Leu Ser Ser Ala Arg Trp Gly Val Cys Trp Val Asn Phe Glu 
                85                  90                  95      


Ala Leu Ile Ile Thr Met Ser Val Val Gly Gly Thr Leu Leu Leu Gly 
            100                 105                 110         


Ile Ala Ile Cys Cys Cys Cys Cys Cys Arg Arg Lys Arg Ser Arg Lys 
        115                 120                 125             


Pro Asp Arg Ser Glu Glu Lys Ala Met Arg Glu Arg Glu Glu Arg Arg 
    130                 135                 140                 


Ile Arg Gln Glu Glu Arg Arg Ala Glu Met Lys Thr Arg His Asp Glu 
145                 150                 155                 160 


Ile Arg Lys Lys Tyr Gly Leu Phe Lys Glu Glu Asn Pro Tyr Ala Arg 
                165                 170                 175     


Phe Glu Asn Asn 
            180 


<210>  3027
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  3027

Met Gly Thr Met Lys Thr Gln Arg Asp Gly His Ser Leu Gly Arg Trp 
1               5                   10                  15      


Ser Leu Val Leu Leu Leu Leu Gly Leu Val Met Pro Leu Ala Ile Ile 
            20                  25                  30          


Ala Gln Val Leu Ser Tyr Lys Glu Ala Val Leu Arg Ala Ile Asp Gly 
        35                  40                  45              


Ile Asn Gln Arg Ser Ser Asp Ala Asn Leu Tyr Arg Leu Leu Asp Leu 
    50                  55                  60                  


Asp Pro Arg Pro Thr Met Asp Gly Asp Pro Asp Thr Pro Lys Pro Val 
65                  70                  75                  80  


Ser Phe Thr Val Lys Glu Thr Val Cys Pro Arg Thr Thr Gln Gln Ser 
                85                  90                  95      


Pro Glu Asp Cys Asp Phe Lys Lys Asp Gly Leu Val Lys Arg Cys Met 
            100                 105                 110         


Gly Thr Val Thr Leu Asn Gln Ala Arg Gly Ser Phe Asp Ile Ser Cys 
        115                 120                 125             


Asp Lys Asp Asn Lys Arg Phe Ala Leu Leu Gly Asp Phe Phe Arg Lys 
    130                 135                 140                 


Ser Lys Glu Lys Ile Gly Lys Glu Phe Lys Arg Ile Val Gln Arg Ile 
145                 150                 155                 160 


Lys Asp Phe Leu Arg Asn Leu Val Pro Arg Thr Glu Ser 
                165                 170             


<210>  3028
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  3028

Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val 
1               5                   10                  15      


Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala 
            20                  25                  30          


Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu 
        35                  40                  45              


Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile 
    50                  55                  60                  


Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys 
65                  70                  75                  80  


Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr 
                85                  90                  95      


Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly 
            100                 105                 110         


Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
        115                 120                 125             


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
    130                 135                 140                 


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
145                 150                 155                 160 


Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
                165                 170                 175     


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
            180                 185                 190         


Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala 
        195                 200                 205             


Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met 
    210                 215                 220                 


Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr 
225                 230                 235     


<210>  3029
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  3029

Met Gly Glu Phe Asn Glu Lys Lys Thr Thr Cys Gly Thr Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Thr Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Thr Tyr Leu Ala Thr Ala Tyr Ile Leu 
    50                  55                  60                  


Val Val Ala Gly Thr Val Val Met Val Thr Gly Val Leu Gly Cys Cys 
65                  70                  75                  80  


Ala Thr Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu 
                85                  90                  95      


Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr 
            100                 105                 110         


Ala Tyr Tyr Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu Lys Asp 
        115                 120                 125             


Thr Met Thr Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Thr Ser 
    130                 135                 140                 


Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn 
145                 150                 155                 160 


Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly 
                165                 170                 175     


Gly Arg Val Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala Leu Cys 
            180                 185                 190         


Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly Gly Cys 
        195                 200                 205             


Ile Thr Lys Leu Glu Thr Phe Ile Gln Glu His Leu Arg Val Ile Gly 
    210                 215                 220                 


Ala Val Gly Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met Ile Phe 
225                 230                 235                 240 


Thr Cys Cys Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr 
                245                 250             


<210>  3030
<211>  882
<212>  PRT
<213>  Homo sapiens

<400>  3030

Met Gly Pro Trp Ser Arg Ser Leu Ser Ala Leu Leu Leu Leu Leu Gln 
1               5                   10                  15      


Val Ser Ser Trp Leu Cys Gln Glu Pro Glu Pro Cys His Pro Gly Phe 
            20                  25                  30          


Asp Ala Glu Ser Tyr Thr Phe Thr Val Pro Arg Arg His Leu Glu Arg 
        35                  40                  45              


Gly Arg Val Leu Gly Arg Val Asn Phe Glu Asp Cys Thr Gly Arg Gln 
    50                  55                  60                  


Arg Thr Ala Tyr Phe Ser Leu Asp Thr Arg Phe Lys Val Gly Thr Asp 
65                  70                  75                  80  


Gly Val Ile Thr Val Lys Arg Pro Leu Arg Phe His Asn Pro Gln Ile 
                85                  90                  95      


His Phe Leu Val Tyr Ala Trp Asp Ser Thr Tyr Arg Lys Phe Ser Thr 
            100                 105                 110         


Lys Val Thr Leu Asn Thr Val Gly His His His Arg Pro Pro Pro His 
        115                 120                 125             


Gln Ala Ser Val Ser Gly Ile Gln Ala Glu Leu Leu Thr Phe Pro Asn 
    130                 135                 140                 


Ser Ser Pro Gly Leu Arg Arg Gln Lys Arg Asp Trp Val Ile Pro Pro 
145                 150                 155                 160 


Ile Ser Cys Pro Glu Asn Glu Lys Gly Pro Phe Pro Lys Asn Leu Val 
                165                 170                 175     


Gln Ile Lys Ser Asn Lys Asp Lys Glu Gly Lys Val Phe Tyr Ser Ile 
            180                 185                 190         


Thr Gly Gln Gly Ala Asp Thr Pro Pro Val Gly Val Phe Ile Ile Glu 
        195                 200                 205             


Arg Glu Thr Gly Trp Leu Lys Val Thr Glu Pro Leu Asp Arg Glu Arg 
    210                 215                 220                 


Ile Ala Thr Tyr Thr Leu Phe Ser His Ala Val Ser Ser Asn Gly Asn 
225                 230                 235                 240 


Ala Val Glu Asp Pro Met Glu Ile Leu Ile Thr Val Thr Asp Gln Asn 
                245                 250                 255     


Asp Asn Lys Pro Glu Phe Thr Gln Glu Val Phe Lys Gly Ser Val Met 
            260                 265                 270         


Glu Gly Ala Leu Pro Gly Thr Ser Val Met Glu Val Thr Ala Thr Asp 
        275                 280                 285             


Ala Asp Asp Asp Val Asn Thr Tyr Asn Ala Ala Ile Ala Tyr Thr Ile 
    290                 295                 300                 


Leu Ser Gln Asp Pro Glu Leu Pro Asp Lys Asn Met Phe Thr Ile Asn 
305                 310                 315                 320 


Arg Asn Thr Gly Val Ile Ser Val Val Thr Thr Gly Leu Asp Arg Glu 
                325                 330                 335     


Ser Phe Pro Thr Tyr Thr Leu Val Val Gln Ala Ala Asp Leu Gln Gly 
            340                 345                 350         


Glu Gly Leu Ser Thr Thr Ala Thr Ala Val Ile Thr Val Thr Asp Thr 
        355                 360                 365             


Asn Asp Asn Pro Pro Ile Phe Asn Pro Thr Thr Tyr Lys Gly Gln Val 
    370                 375                 380                 


Pro Glu Asn Glu Ala Asn Val Val Ile Thr Thr Leu Lys Val Thr Asp 
385                 390                 395                 400 


Ala Asp Ala Pro Asn Thr Pro Ala Trp Glu Ala Val Tyr Thr Ile Leu 
                405                 410                 415     


Asn Asp Asp Gly Gly Gln Phe Val Val Thr Thr Asn Pro Val Asn Asn 
            420                 425                 430         


Asp Gly Ile Leu Lys Thr Ala Lys Gly Leu Asp Phe Glu Ala Lys Gln 
        435                 440                 445             


Gln Tyr Ile Leu His Val Ala Val Thr Asn Val Val Pro Phe Glu Val 
    450                 455                 460                 


Ser Leu Thr Thr Ser Thr Ala Thr Val Thr Val Asp Val Leu Asp Val 
465                 470                 475                 480 


Asn Glu Ala Pro Ile Phe Val Pro Pro Glu Lys Arg Val Glu Val Ser 
                485                 490                 495     


Glu Asp Phe Gly Val Gly Gln Glu Ile Thr Ser Tyr Thr Ala Gln Glu 
            500                 505                 510         


Pro Asp Thr Phe Met Glu Gln Lys Ile Thr Tyr Arg Ile Trp Arg Asp 
        515                 520                 525             


Thr Ala Asn Trp Leu Glu Ile Asn Pro Asp Thr Gly Ala Ile Ser Thr 
    530                 535                 540                 


Arg Ala Glu Leu Asp Arg Glu Asp Phe Glu His Val Lys Asn Ser Thr 
545                 550                 555                 560 


Tyr Thr Ala Leu Ile Ile Ala Thr Asp Asn Gly Ser Pro Val Ala Thr 
                565                 570                 575     


Gly Thr Gly Thr Leu Leu Leu Ile Leu Ser Asp Val Asn Asp Asn Ala 
            580                 585                 590         


Pro Ile Pro Glu Pro Arg Thr Ile Phe Phe Cys Glu Arg Asn Pro Lys 
        595                 600                 605             


Pro Gln Val Ile Asn Ile Ile Asp Ala Asp Leu Pro Pro Asn Thr Ser 
    610                 615                 620                 


Pro Phe Thr Ala Glu Leu Thr His Gly Ala Ser Ala Asn Trp Thr Ile 
625                 630                 635                 640 


Gln Tyr Asn Asp Pro Thr Gln Glu Ser Ile Ile Leu Lys Pro Lys Met 
                645                 650                 655     


Ala Leu Glu Val Gly Asp Tyr Lys Ile Asn Leu Lys Leu Met Asp Asn 
            660                 665                 670         


Gln Asn Lys Asp Gln Val Thr Thr Leu Glu Val Ser Val Cys Asp Cys 
        675                 680                 685             


Glu Gly Ala Ala Gly Val Cys Arg Lys Ala Gln Pro Val Glu Ala Gly 
    690                 695                 700                 


Leu Gln Ile Pro Ala Ile Leu Gly Ile Leu Gly Gly Ile Leu Ala Leu 
705                 710                 715                 720 


Leu Ile Leu Ile Leu Leu Leu Leu Leu Phe Leu Arg Arg Arg Ala Val 
                725                 730                 735     


Val Lys Glu Pro Leu Leu Pro Pro Glu Asp Asp Thr Arg Asp Asn Val 
            740                 745                 750         


Tyr Tyr Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp Phe Asp 
        755                 760                 765             


Leu Ser Gln Leu His Arg Gly Leu Asp Ala Arg Pro Glu Val Thr Arg 
    770                 775                 780                 


Asn Asp Val Ala Pro Thr Leu Met Ser Val Pro Arg Tyr Leu Pro Arg 
785                 790                 795                 800 


Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp Glu Asn Leu Lys 
                805                 810                 815     


Ala Ala Asp Thr Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Leu Val 
            820                 825                 830         


Phe Asp Tyr Glu Gly Ser Gly Ser Glu Ala Ala Ser Leu Ser Ser Leu 
        835                 840                 845             


Asn Ser Ser Glu Ser Asp Lys Asp Gln Asp Tyr Asp Tyr Leu Asn Glu 
    850                 855                 860                 


Trp Gly Asn Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Gly Glu 
865                 870                 875                 880 


Asp Asp 
        


<210>  3031
<211>  785
<212>  PRT
<213>  Homo sapiens

<400>  3031

Met Lys Leu Gly Lys Val Glu Phe Cys His Phe Leu Gln Leu Ile Ala 
1               5                   10                  15      


Leu Phe Leu Cys Phe Ser Gly Met Ser Gln Ala Glu Leu Ser Arg Ser 
            20                  25                  30          


Arg Ser Lys Pro Tyr Phe Gln Ser Gly Arg Ser Arg Thr Lys Arg Ser 
        35                  40                  45              


Trp Val Trp Asn Gln Phe Phe Val Leu Glu Glu Tyr Met Gly Ser Asp 
    50                  55                  60                  


Pro Leu Tyr Val Gly Lys Leu His Ser Asp Val Asp Lys Gly Asp Gly 
65                  70                  75                  80  


Ser Ile Lys Tyr Ile Leu Ser Gly Glu Gly Ala Ser Ser Ile Phe Ile 
                85                  90                  95      


Ile Asp Glu Asn Thr Gly Asp Ile His Ala Thr Lys Arg Leu Asp Arg 
            100                 105                 110         


Glu Glu Gln Ala Tyr Tyr Thr Leu Arg Ala Gln Ala Leu Asp Arg Leu 
        115                 120                 125             


Thr Asn Lys Pro Val Glu Pro Glu Ser Glu Phe Val Ile Lys Ile Gln 
    130                 135                 140                 


Asp Ile Asn Asp Asn Glu Pro Lys Phe Leu Asp Gly Pro Tyr Thr Ala 
145                 150                 155                 160 


Gly Val Pro Glu Met Ser Pro Val Gly Thr Ser Val Val Gln Val Thr 
                165                 170                 175     


Ala Thr Asp Ala Asp Asp Pro Thr Tyr Gly Asn Ser Ala Arg Val Val 
            180                 185                 190         


Tyr Ser Ile Leu Gln Gly Gln Pro Tyr Phe Ser Val Glu Pro Lys Thr 
        195                 200                 205             


Gly Val Ile Lys Thr Ala Leu Pro Asn Met Asp Arg Glu Ala Lys Asp 
    210                 215                 220                 


Gln Tyr Leu Leu Val Ile Gln Ala Lys Asp Met Val Gly Gln Asn Gly 
225                 230                 235                 240 


Gly Leu Ser Gly Thr Thr Ser Val Thr Val Thr Leu Thr Asp Val Asn 
                245                 250                 255     


Asp Asn Pro Pro Arg Phe Pro Arg Arg Ser Tyr Gln Tyr Asn Val Pro 
            260                 265                 270         


Glu Ser Leu Pro Val Ala Ser Val Val Ala Arg Ile Lys Ala Ala Asp 
        275                 280                 285             


Ala Asp Ile Gly Ala Asn Ala Glu Met Glu Tyr Lys Ile Val Asp Gly 
    290                 295                 300                 


Asp Gly Leu Gly Ile Phe Lys Ile Ser Val Asp Lys Glu Thr Gln Glu 
305                 310                 315                 320 


Gly Ile Ile Thr Ile Gln Lys Glu Leu Asp Phe Glu Ala Lys Thr Ser 
                325                 330                 335     


Tyr Thr Leu Arg Ile Glu Ala Ala Asn Lys Asp Ala Asp Pro Arg Phe 
            340                 345                 350         


Leu Ser Leu Gly Pro Phe Ser Asp Thr Thr Thr Val Lys Ile Ile Val 
        355                 360                 365             


Glu Asp Val Asp Glu Pro Pro Val Phe Ser Ser Pro Leu Tyr Pro Met 
    370                 375                 380                 


Glu Val Ser Glu Ala Thr Gln Val Gly Asn Ile Ile Gly Thr Val Ala 
385                 390                 395                 400 


Ala His Asp Pro Asp Ser Ser Asn Ser Pro Val Arg Tyr Ser Ile Asp 
                405                 410                 415     


Arg Asn Thr Asp Leu Glu Arg Tyr Phe Asn Ile Asp Ala Asn Ser Gly 
            420                 425                 430         


Val Ile Thr Thr Ala Lys Ser Leu Asp Arg Glu Thr Asn Ala Ile His 
        435                 440                 445             


Asn Ile Thr Val Leu Ala Met Glu Ser Gln Asn Pro Ser Gln Val Gly 
    450                 455                 460                 


Arg Gly Tyr Val Ala Ile Thr Ile Leu Asp Ile Asn Asp Asn Ala Pro 
465                 470                 475                 480 


Glu Phe Ala Met Asp Tyr Glu Thr Thr Val Cys Glu Asn Ala Gln Pro 
                485                 490                 495     


Gly Gln Val Ile Gln Lys Ile Ser Ala Val Asp Lys Asp Glu Pro Ser 
            500                 505                 510         


Asn Gly His Gln Phe Tyr Phe Ser Leu Thr Thr Asp Ala Thr Asn Asn 
        515                 520                 525             


His Asn Phe Ser Leu Lys Asp Asn Lys Asp Asn Thr Ala Ser Ile Leu 
    530                 535                 540                 


Thr Arg Arg Asn Gly Phe Arg Arg Gln Glu Gln Ser Val Tyr Tyr Leu 
545                 550                 555                 560 


Pro Ile Phe Ile Val Asp Ser Gly Ser Pro Ser Leu Ser Ser Thr Asn 
                565                 570                 575     


Thr Leu Thr Ile Arg Val Cys Asp Cys Asp Ala Asp Gly Val Ala Gln 
            580                 585                 590         


Thr Cys Asn Ala Glu Ala Tyr Val Leu Pro Ala Gly Leu Ser Thr Gly 
        595                 600                 605             


Ala Leu Ile Ala Ile Leu Ala Cys Val Leu Thr Leu Leu Val Leu Ile 
    610                 615                 620                 


Leu Leu Ile Val Thr Met Arg Arg Arg Lys Lys Glu Pro Leu Ile Phe 
625                 630                 635                 640 


Asp Glu Glu Arg Asp Ile Arg Glu Asn Ile Val Arg Tyr Asp Asp Glu 
                645                 650                 655     


Gly Gly Gly Glu Glu Asp Thr Glu Ala Phe Asp Met Ala Ala Leu Arg 
            660                 665                 670         


Asn Leu Asn Val Ile Arg Asp Thr Lys Thr Arg Arg Asp Val Thr Pro 
        675                 680                 685             


Glu Ile Gln Phe Leu Ser Arg Pro Ala Phe Lys Ser Ile Pro Asp Asn 
    690                 695                 700                 


Val Ile Phe Arg Glu Phe Ile Trp Glu Arg Leu Lys Glu Ala Asp Val 
705                 710                 715                 720 


Asp Pro Gly Ala Pro Pro Tyr Asp Ser Leu Gln Thr Tyr Ala Phe Glu 
                725                 730                 735     


Gly Asn Gly Ser Val Ala Glu Ser Leu Ser Ser Leu Asp Ser Ile Ser 
            740                 745                 750         


Ser Asn Ser Asp Gln Asn Tyr Asp Tyr Leu Ser Asp Trp Gly Pro Arg 
        755                 760                 765             


Phe Lys Arg Leu Ala Asp Met Tyr Gly Thr Gly Gln Glu Ser Leu Tyr 
    770                 775                 780                 


Ser 
785 


<210>  3032
<211>  610
<212>  PRT
<213>  Homo sapiens

<400>  3032

Met His Phe Gln Ala Phe Trp Leu Cys Leu Gly Leu Leu Phe Ile Ser 
1               5                   10                  15      


Ile Asn Ala Glu Phe Met Asp Asp Asp Val Glu Thr Glu Asp Phe Glu 
            20                  25                  30          


Glu Asn Ser Glu Glu Ile Asp Val Asn Glu Ser Glu Leu Ser Ser Glu 
        35                  40                  45              


Ile Lys Tyr Lys Thr Pro Gln Pro Ile Gly Glu Val Tyr Phe Ala Glu 
    50                  55                  60                  


Thr Phe Asp Ser Gly Arg Leu Ala Gly Trp Val Leu Ser Lys Ala Lys 
65                  70                  75                  80  


Lys Asp Asp Met Asp Glu Glu Ile Ser Ile Tyr Asp Gly Arg Trp Glu 
                85                  90                  95      


Ile Glu Glu Leu Lys Glu Asn Gln Val Pro Gly Asp Arg Gly Leu Val 
            100                 105                 110         


Leu Lys Ser Arg Ala Lys His His Ala Ile Ser Ala Val Leu Ala Lys 
        115                 120                 125             


Pro Phe Ile Phe Ala Asp Lys Pro Leu Ile Val Gln Tyr Glu Val Asn 
    130                 135                 140                 


Phe Gln Asp Gly Ile Asp Cys Gly Gly Ala Tyr Ile Lys Leu Leu Ala 
145                 150                 155                 160 


Asp Thr Asp Asp Leu Ile Leu Glu Asn Phe Tyr Asp Lys Thr Ser Tyr 
                165                 170                 175     


Ile Ile Met Phe Gly Pro Asp Lys Cys Gly Glu Asp Tyr Lys Leu His 
            180                 185                 190         


Phe Ile Phe Arg His Lys His Pro Lys Thr Gly Val Phe Glu Glu Lys 
        195                 200                 205             


His Ala Lys Pro Pro Asp Val Asp Leu Lys Lys Phe Phe Thr Asp Arg 
    210                 215                 220                 


Lys Thr His Leu Tyr Thr Leu Val Met Asn Pro Asp Asp Thr Phe Glu 
225                 230                 235                 240 


Val Leu Val Asp Gln Thr Val Val Asn Lys Gly Ser Leu Leu Glu Asp 
                245                 250                 255     


Val Val Pro Pro Ile Lys Pro Pro Lys Glu Ile Glu Asp Pro Asn Asp 
            260                 265                 270         


Lys Lys Pro Glu Glu Trp Asp Glu Arg Ala Lys Ile Pro Asp Pro Ser 
        275                 280                 285             


Ala Val Lys Pro Glu Asp Trp Asp Glu Ser Glu Pro Ala Gln Ile Glu 
    290                 295                 300                 


Asp Ser Ser Val Val Lys Pro Ala Gly Trp Leu Asp Asp Glu Pro Lys 
305                 310                 315                 320 


Phe Ile Pro Asp Pro Asn Ala Glu Lys Pro Asp Asp Trp Asn Glu Asp 
                325                 330                 335     


Thr Asp Gly Glu Trp Glu Ala Pro Gln Ile Leu Asn Pro Ala Cys Arg 
            340                 345                 350         


Ile Gly Cys Gly Glu Trp Lys Pro Pro Met Ile Asp Asn Pro Lys Tyr 
        355                 360                 365             


Lys Gly Val Trp Arg Pro Pro Leu Val Asp Asn Pro Asn Tyr Gln Gly 
    370                 375                 380                 


Ile Trp Ser Pro Arg Lys Ile Pro Asn Pro Asp Tyr Phe Glu Asp Asp 
385                 390                 395                 400 


His Pro Phe Leu Leu Thr Ser Phe Ser Ala Leu Gly Leu Glu Leu Trp 
                405                 410                 415     


Ser Met Thr Ser Asp Ile Tyr Phe Asp Asn Phe Ile Ile Cys Ser Glu 
            420                 425                 430         


Lys Glu Val Ala Asp His Trp Ala Ala Asp Gly Trp Arg Trp Lys Ile 
        435                 440                 445             


Met Ile Ala Asn Ala Asn Lys Pro Gly Val Leu Lys Gln Leu Met Ala 
    450                 455                 460                 


Ala Ala Glu Gly His Pro Trp Leu Trp Leu Ile Tyr Leu Val Thr Ala 
465                 470                 475                 480 


Gly Val Pro Ile Ala Leu Ile Thr Ser Phe Cys Trp Pro Arg Lys Val 
                485                 490                 495     


Lys Lys Lys His Lys Asp Thr Glu Tyr Lys Lys Thr Asp Ile Cys Ile 
            500                 505                 510         


Pro Gln Thr Lys Gly Val Leu Glu Gln Glu Glu Lys Glu Glu Lys Ala 
        515                 520                 525             


Ala Leu Glu Lys Pro Met Asp Leu Glu Glu Glu Lys Lys Gln Asn Asp 
    530                 535                 540                 


Gly Glu Met Leu Glu Lys Glu Glu Glu Ser Glu Pro Glu Glu Lys Ser 
545                 550                 555                 560 


Glu Glu Glu Ile Glu Ile Ile Glu Gly Gln Glu Glu Ser Asn Gln Ser 
                565                 570                 575     


Asn Lys Ser Gly Ser Glu Asp Glu Met Lys Glu Ala Asp Glu Ser Thr 
            580                 585                 590         


Gly Ser Gly Asp Gly Pro Ile Lys Ser Val Arg Lys Arg Arg Val Arg 
        595                 600                 605             


Lys Asp 
    610 


<210>  3033
<211>  898
<212>  PRT
<213>  Homo sapiens

<400>  3033

Met Ala Ala Ala Ala Ala Glu Glu Gly Met Glu Pro Arg Ala Leu Gln 
1               5                   10                  15      


Tyr Glu Gln Thr Leu Met Tyr Gly Arg Tyr Thr Gln Asp Leu Gly Ala 
            20                  25                  30          


Phe Ala Lys Glu Glu Ala Ala Arg Ile Arg Leu Gly Gly Pro Glu Pro 
        35                  40                  45              


Trp Lys Gly Pro Pro Ser Ser Arg Ala Ala Pro Glu Leu Leu Glu Tyr 
    50                  55                  60                  


Gly Arg Ser Arg Cys Ala Arg Cys Arg Val Cys Ser Val Arg Cys His 
65                  70                  75                  80  


Lys Phe Leu Val Ser Arg Val Gly Glu Asp Trp Ile Phe Leu Val Leu 
                85                  90                  95      


Leu Gly Leu Leu Met Ala Leu Val Ser Trp Val Met Asp Tyr Ala Ile 
            100                 105                 110         


Ala Ala Cys Leu Gln Ala Gln Gln Trp Met Ser Arg Gly Leu Asn Thr 
        115                 120                 125             


Ser Ile Leu Leu Gln Tyr Leu Ala Trp Val Thr Tyr Pro Val Val Leu 
    130                 135                 140                 


Ile Thr Phe Ser Ala Gly Phe Thr Gln Ile Leu Ala Pro Gln Ala Val 
145                 150                 155                 160 


Gly Ser Gly Ile Pro Glu Met Lys Thr Ile Leu Arg Gly Val Val Leu 
                165                 170                 175     


Lys Glu Tyr Leu Thr Leu Lys Thr Phe Ile Ala Lys Val Ile Gly Leu 
            180                 185                 190         


Thr Cys Ala Leu Gly Ser Gly Met Pro Leu Gly Lys Glu Gly Pro Phe 
        195                 200                 205             


Val His Ile Ala Ser Met Cys Ala Ala Leu Leu Ser Lys Phe Leu Ser 
    210                 215                 220                 


Leu Phe Gly Gly Ile Tyr Glu Asn Glu Ser Arg Asn Thr Glu Met Leu 
225                 230                 235                 240 


Ala Ala Ala Cys Ala Val Gly Val Gly Cys Cys Phe Ala Ala Pro Ile 
                245                 250                 255     


Gly Gly Val Leu Phe Ser Ile Glu Val Thr Ser Thr Phe Phe Ala Val 
            260                 265                 270         


Arg Asn Tyr Trp Arg Gly Phe Phe Ala Ala Thr Phe Ser Ala Phe Ile 
        275                 280                 285             


Phe Arg Val Leu Ala Val Trp Asn Arg Asp Glu Glu Thr Ile Thr Ala 
    290                 295                 300                 


Leu Phe Lys Thr Arg Phe Arg Leu Asp Phe Pro Phe Asp Leu Gln Glu 
305                 310                 315                 320 


Leu Pro Ala Phe Ala Val Ile Gly Ile Ala Ser Gly Phe Gly Gly Ala 
                325                 330                 335     


Leu Phe Val Tyr Leu Asn Arg Lys Ile Val Gln Val Met Arg Lys Gln 
            340                 345                 350         


Lys Thr Ile Asn Arg Phe Leu Met Arg Lys Arg Leu Leu Phe Pro Ala 
        355                 360                 365             


Leu Val Thr Leu Leu Ile Ser Thr Leu Thr Phe Pro Pro Gly Phe Gly 
    370                 375                 380                 


Gln Phe Met Ala Gly Gln Leu Ser Gln Lys Glu Thr Leu Val Thr Leu 
385                 390                 395                 400 


Phe Asp Asn Arg Thr Trp Val Arg Gln Gly Leu Val Glu Glu Leu Glu 
                405                 410                 415     


Pro Pro Ser Thr Ser Gln Ala Trp Asn Pro Pro Arg Ala Asn Val Phe 
            420                 425                 430         


Leu Thr Leu Val Ile Phe Ile Leu Met Lys Phe Trp Met Ser Ala Leu 
        435                 440                 445             


Ala Thr Thr Ile Pro Val Pro Cys Gly Ala Phe Met Pro Val Phe Val 
    450                 455                 460                 


Ile Gly Ala Ala Phe Gly Arg Leu Val Gly Glu Ser Met Ala Ala Trp 
465                 470                 475                 480 


Phe Pro Asp Gly Ile His Thr Asp Ser Ser Thr Tyr Arg Ile Val Pro 
                485                 490                 495     


Gly Gly Tyr Ala Val Val Gly Ala Ala Ala Leu Ala Gly Ala Val Thr 
            500                 505                 510         


His Thr Val Ser Thr Ala Val Ile Val Phe Glu Leu Thr Gly Gln Ile 
        515                 520                 525             


Ala His Ile Leu Pro Val Met Ile Ala Val Ile Leu Ala Asn Ala Val 
    530                 535                 540                 


Ala Gln Ser Leu Gln Pro Ser Leu Tyr Asp Ser Ile Ile Arg Ile Lys 
545                 550                 555                 560 


Lys Leu Pro Tyr Leu Pro Glu Leu Gly Trp Gly Arg His Gln Gln Tyr 
                565                 570                 575     


Arg Val Arg Val Glu Asp Ile Met Val Arg Asp Val Pro His Val Ala 
            580                 585                 590         


Leu Ser Cys Thr Phe Arg Asp Leu Arg Leu Ala Leu His Arg Thr Lys 
        595                 600                 605             


Gly Arg Met Leu Ala Leu Val Glu Ser Pro Glu Ser Met Ile Leu Leu 
    610                 615                 620                 


Gly Ser Ile Glu Arg Ser Gln Val Val Ala Leu Leu Gly Ala Gln Leu 
625                 630                 635                 640 


Ser Pro Ala Arg Arg Arg Gln His Met Gln Glu Arg Arg Ala Thr Gln 
                645                 650                 655     


Thr Ser Pro Leu Ser Asp Gln Glu Gly Pro Pro Thr Pro Glu Ala Ser 
            660                 665                 670         


Val Cys Phe Gln Val Asn Thr Glu Asp Ser Ala Phe Pro Ala Ala Arg 
        675                 680                 685             


Gly Glu Thr His Lys Pro Leu Lys Pro Ala Leu Lys Arg Gly Pro Ser 
    690                 695                 700                 


Val Thr Arg Asn Leu Gly Glu Ser Pro Thr Gly Ser Ala Glu Ser Ala 
705                 710                 715                 720 


Gly Ile Ala Leu Arg Ser Leu Phe Cys Gly Ser Pro Pro Pro Glu Ala 
                725                 730                 735     


Ala Ser Glu Lys Leu Glu Ser Cys Glu Lys Arg Lys Leu Lys Arg Val 
            740                 745                 750         


Arg Ile Ser Leu Ala Ser Asp Ala Asp Leu Glu Gly Glu Met Ser Pro 
        755                 760                 765             


Glu Glu Ile Leu Glu Trp Glu Glu Gln Gln Leu Asp Glu Pro Val Asn 
    770                 775                 780                 


Phe Ser Asp Cys Lys Ile Asp Pro Ala Pro Phe Gln Leu Val Glu Arg 
785                 790                 795                 800 


Thr Ser Leu His Lys Thr His Thr Ile Phe Ser Leu Leu Gly Val Asp 
                805                 810                 815     


His Ala Tyr Val Thr Ser Ile Gly Arg Leu Ile Gly Ile Val Thr Leu 
            820                 825                 830         


Lys Glu Leu Arg Lys Ala Ile Glu Gly Ser Val Thr Ala Gln Gly Val 
        835                 840                 845             


Lys Val Arg Pro Pro Leu Ala Ser Phe Arg Asp Ser Ala Thr Ser Ser 
    850                 855                 860                 


Ser Asp Thr Glu Thr Thr Glu Val His Ala Leu Trp Gly Pro His Ser 
865                 870                 875                 880 


Arg His Gly Leu Pro Arg Glu Gly Ser Pro Ser Asp Ser Asp Asp Lys 
                885                 890                 895     


Cys Gln 
        


<210>  3034
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  3034

Met Ser Gly Glu Ser Met Asn Phe Ser Asp Val Phe Asp Ser Ser Glu 
1               5                   10                  15      


Asp Tyr Phe Val Ser Val Asn Thr Ser Tyr Tyr Ser Val Asp Ser Glu 
            20                  25                  30          


Met Leu Leu Cys Ser Leu Gln Glu Val Arg Gln Phe Ser Arg Leu Phe 
        35                  40                  45              


Val Pro Ile Ala Tyr Ser Leu Ile Cys Val Phe Gly Leu Leu Gly Asn 
    50                  55                  60                  


Ile Leu Val Val Ile Thr Phe Ala Phe Tyr Lys Lys Ala Arg Ser Met 
65                  70                  75                  80  


Thr Asp Val Tyr Leu Leu Asn Met Ala Ile Ala Asp Ile Leu Phe Val 
                85                  90                  95      


Leu Thr Leu Pro Phe Trp Ala Val Ser His Ala Thr Gly Ala Trp Val 
            100                 105                 110         


Phe Ser Asn Ala Thr Cys Lys Leu Leu Lys Gly Ile Tyr Ala Ile Asn 
        115                 120                 125             


Phe Asn Cys Gly Met Leu Leu Leu Thr Cys Ile Ser Met Asp Arg Tyr 
    130                 135                 140                 


Ile Ala Ile Val Gln Ala Thr Lys Ser Phe Arg Leu Arg Ser Arg Thr 
145                 150                 155                 160 


Leu Pro Arg Ser Lys Ile Ile Cys Leu Val Val Trp Gly Leu Ser Val 
                165                 170                 175     


Ile Ile Ser Ser Ser Thr Phe Val Phe Asn Gln Lys Tyr Asn Thr Gln 
            180                 185                 190         


Gly Ser Asp Val Cys Glu Pro Lys Tyr Gln Thr Val Ser Glu Pro Ile 
        195                 200                 205             


Arg Trp Lys Leu Leu Met Leu Gly Leu Glu Leu Leu Phe Gly Phe Phe 
    210                 215                 220                 


Ile Pro Leu Met Phe Met Ile Phe Cys Tyr Thr Phe Ile Val Lys Thr 
225                 230                 235                 240 


Leu Val Gln Ala Gln Asn Ser Lys Arg His Lys Ala Ile Arg Val Ile 
                245                 250                 255     


Ile Ala Val Val Leu Val Phe Leu Ala Cys Gln Ile Pro His Asn Met 
            260                 265                 270         


Val Leu Leu Val Thr Ala Ala Asn Leu Gly Lys Met Asn Arg Ser Cys 
        275                 280                 285             


Gln Ser Glu Lys Leu Ile Gly Tyr Thr Lys Thr Val Thr Glu Val Leu 
    290                 295                 300                 


Ala Phe Leu His Cys Cys Leu Asn Pro Val Leu Tyr Ala Phe Ile Gly 
305                 310                 315                 320 


Gln Lys Phe Arg Asn Tyr Phe Leu Lys Ile Leu Lys Asp Leu Trp Cys 
                325                 330                 335     


Val Arg Arg Lys Tyr Lys Ser Ser Gly Phe Ser Cys Ala Gly Arg Tyr 
            340                 345                 350         


Ser Glu Asn Ile Ser Arg Gln Thr Ser Glu Thr Ala Asp Asn Asp Asn 
        355                 360                 365             


Ala Ser Ser Phe Thr Met 
    370                 


<210>  3035
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  3035

Met Gly Gly Leu Trp Arg Pro Gly Trp Arg Cys Val Pro Phe Cys Gly 
1               5                   10                  15      


Trp Arg Trp Ile His Pro Gly Ser Pro Thr Arg Ala Ala Glu Arg Val 
            20                  25                  30          


Glu Pro Phe Leu Arg Pro Glu Trp Ser Gly Thr Gly Gly Ala Glu Arg 
        35                  40                  45              


Gly Leu Arg Trp Leu Gly Thr Trp Lys Arg Cys Ser Leu Arg Ala Arg 
    50                  55                  60                  


His Pro Ala Leu Gln Pro Pro Arg Arg Pro Lys Ser Ser Asn Pro Phe 
65                  70                  75                  80  


Thr Arg Ala Gln Glu Glu Glu Arg Arg Arg Gln Asn Lys Thr Thr Leu 
                85                  90                  95      


Thr Tyr Val Ala Ala Val Ala Val Gly Met Leu Gly Ala Ser Tyr Ala 
            100                 105                 110         


Ala Val Pro Leu Tyr Arg Leu Tyr Cys Gln Thr Thr Gly Leu Gly Gly 
        115                 120                 125             


Ser Ala Val Ala Gly His Ala Ser Asp Lys Ile Glu Asn Met Val Pro 
    130                 135                 140                 


Val Lys Asp Arg Ile Ile Lys Ile Ser Phe Asn Ala Asp Val His Ala 
145                 150                 155                 160 


Ser Leu Gln Trp Asn Phe Arg Pro Gln Gln Thr Glu Ile Tyr Val Val 
                165                 170                 175     


Pro Gly Glu Thr Ala Leu Ala Phe Tyr Arg Ala Lys Asn Pro Thr Asp 
            180                 185                 190         


Lys Pro Val Ile Gly Ile Ser Thr Tyr Asn Ile Val Pro Phe Glu Ala 
        195                 200                 205             


Gly Gln Tyr Phe Asn Lys Ile Gln Cys Phe Cys Phe Glu Glu Gln Arg 
    210                 215                 220                 


Leu Asn Pro Gln Glu Glu Val Asp Met Pro Val Phe Phe Tyr Ile Asp 
225                 230                 235                 240 


Pro Glu Phe Ala Glu Asp Pro Arg Met Ile Lys Val Asp Leu Ile Thr 
                245                 250                 255     


Leu Ser Tyr Thr Phe Phe Glu Ala Lys Glu Gly His Lys Leu Pro Val 
            260                 265                 270         


Pro Gly Tyr Asn 
        275     


<210>  3036
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  3036

Met Gln Arg Leu Leu Phe Pro Pro Leu Arg Ala Leu Lys Gly Arg Gln 
1               5                   10                  15      


Tyr Leu Pro Leu Leu Ala Pro Arg Ala Ala Pro Arg Ala Gln Cys Asp 
            20                  25                  30          


Cys Ile Arg Arg Pro Leu Arg Pro Gly Gln Tyr Ser Thr Ile Ser Glu 
        35                  40                  45              


Val Ala Leu Gln Ser Gly Arg Gly Thr Val Ser Leu Pro Ser Lys Ala 
    50                  55                  60                  


Ala Glu Arg Val Val Gly Arg Trp Leu Leu Val Cys Ser Gly Thr Val 
65                  70                  75                  80  


Ala Gly Ala Val Ile Leu Gly Gly Val Thr Arg Leu Thr Glu Ser Gly 
                85                  90                  95      


Leu Ser Met Val Asp Trp His Leu Ile Lys Glu Met Lys Pro Pro Thr 
            100                 105                 110         


Ser Gln Glu Glu Trp Glu Ala Glu Phe Gln Arg Tyr Gln Gln Phe Pro 
        115                 120                 125             


Glu Phe Lys Ile Leu Asn His Asp Met Thr Leu Thr Glu Phe Lys Phe 
    130                 135                 140                 


Ile Trp Tyr Met Glu Tyr Ser His Arg Met Trp Gly Arg Leu Val Gly 
145                 150                 155                 160 


Leu Val Tyr Ile Leu Pro Ala Ala Tyr Phe Trp Arg Lys Gly Trp Leu 
                165                 170                 175     


Ser Arg Gly Met Lys Gly Arg Val Leu Ala Leu Cys Gly Leu Val Cys 
            180                 185                 190         


Phe Gln Gly Leu Leu Gly Trp Tyr Met Val Lys Ser Gly Leu Glu Glu 
        195                 200                 205             


Lys Ser Asp Ser His Asp Ile Pro Arg Val Ser Gln Tyr Arg Leu Ala 
    210                 215                 220                 


Ala His Leu Gly Ser Ala Leu Val Leu Tyr Cys Ala Ser Leu Trp Thr 
225                 230                 235                 240 


Ser Leu Ser Leu Leu Leu Pro Pro His Lys Leu Pro Glu Thr His Gln 
                245                 250                 255     


Leu Leu Gln Leu Arg Arg Phe Ala His Gly Thr Ala Gly Leu Val Phe 
            260                 265                 270         


Leu Thr Ala Leu Ser Gly Ala Phe Val Ala Gly Leu Asp Ala Gly Leu 
        275                 280                 285             


Val Tyr Asn Ser Phe Pro Lys Met Gly Glu Ser Trp Ile Pro Glu Asp 
    290                 295                 300                 


Leu Phe Thr Phe Ser Pro Ile Leu Arg Asn Val Phe Glu Asn Pro Thr 
305                 310                 315                 320 


Met Val Gln Phe Asp His Arg Ile Leu Gly Ile Thr Ser Val Thr Ala 
                325                 330                 335     


Ile Thr Val Leu Tyr Phe Leu Ser Arg Arg Ile Pro Leu Pro Arg Arg 
            340                 345                 350         


Thr Lys Met Ala Ala Val Thr Leu Leu Ala Leu Ala Tyr Thr Gln Gly 
        355                 360                 365             


Pro Val Leu Phe Asn Phe Thr Phe Lys Ile Ser Asp Leu Asp Glu Gly 
    370                 375                 380                 


Ile Arg Asn Ile 
385             


<210>  3037
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  3037

Met Gly Gly His Pro Gln Leu Arg Leu Val Lys Ala Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Asn Pro Val Ser Ala Ser Leu Gln Asp Gln His Cys Glu Ser 
            20                  25                  30          


Leu Ser Leu Ala Ser Asn Ile Ser Gly Leu Gln Cys Asn Ala Ser Val 
        35                  40                  45              


Asp Leu Ile Gly Thr Cys Trp Pro Arg Ser Pro Ala Gly Gln Leu Val 
    50                  55                  60                  


Val Arg Pro Cys Pro Ala Phe Phe Tyr Gly Val Arg Tyr Asn Thr Thr 
65                  70                  75                  80  


Asn Asn Gly Tyr Arg Glu Cys Leu Ala Asn Gly Ser Trp Ala Ala Arg 
                85                  90                  95      


Val Asn Tyr Ser Glu Cys Gln Glu Ile Leu Asn Glu Glu Lys Lys Ser 
            100                 105                 110         


Lys Val His Tyr His Val Ala Val Ile Ile Asn Tyr Leu Gly His Cys 
        115                 120                 125             


Ile Ser Leu Val Ala Leu Leu Val Ala Phe Val Leu Phe Leu Arg Leu 
    130                 135                 140                 


Arg Ser Ile Arg Cys Leu Arg Asn Ile Ile His Trp Asn Leu Ile Ser 
145                 150                 155                 160 


Ala Phe Ile Leu Arg Asn Ala Thr Trp Phe Val Val Gln Leu Thr Met 
                165                 170                 175     


Ser Pro Glu Val His Gln Ser Asn Val Gly Trp Cys Arg Leu Val Thr 
            180                 185                 190         


Ala Ala Tyr Asn Tyr Phe His Val Thr Asn Phe Phe Trp Met Phe Gly 
        195                 200                 205             


Glu Gly Cys Tyr Leu His Thr Ala Ile Val Leu Thr Tyr Ser Thr Asp 
    210                 215                 220                 


Arg Leu Arg Lys Trp Met Phe Ile Cys Ile Gly Trp Gly Val Pro Phe 
225                 230                 235                 240 


Pro Ile Ile Val Ala Trp Ala Ile Gly Lys Leu Tyr Tyr Asp Asn Glu 
                245                 250                 255     


Lys Cys Trp Phe Gly Lys Arg Pro Gly Val Tyr Thr Asp Tyr Ile Tyr 
            260                 265                 270         


Gln Gly Pro Met Ile Leu Val Leu Leu Ile Asn Phe Ile Phe Leu Phe 
        275                 280                 285             


Asn Ile Val Arg Ile Leu Met Thr Lys Leu Arg Ala Ser Thr Thr Ser 
    290                 295                 300                 


Glu Thr Ile Gln Tyr Arg Lys Ala Val Lys Ala Thr Leu Val Leu Leu 
305                 310                 315                 320 


Pro Leu Leu Gly Ile Thr Tyr Met Leu Phe Phe Val Asn Pro Gly Glu 
                325                 330                 335     


Asp Glu Val Ser Arg Val Val Phe Ile Tyr Phe Asn Ser Phe Leu Glu 
            340                 345                 350         


Ser Phe Gln Gly Phe Phe Val Ser Val Phe Tyr Cys Phe Leu Asn Ser 
        355                 360                 365             


Glu Val Arg Ser Ala Ile Arg Lys Arg Trp His Arg Trp Gln Asp Lys 
    370                 375                 380                 


His Ser Ile Arg Ala Arg Val Ala Arg Ala Met Ser Ile Pro Thr Ser 
385                 390                 395                 400 


Pro Thr Arg Val Ser Phe His Ser Ile Lys Gln Ser Thr Ala Val 
                405                 410                 415 


<210>  3038
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  3038

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  3039
<211>  895
<212>  PRT
<213>  Homo sapiens

<400>  3039

Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Trp Gly Arg 
1               5                   10                  15      


Thr Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro 
            20                  25                  30          


Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu Asn Gln Leu Glu Ala 
        35                  40                  45              


Ser Met His Ser Val Leu Ser Asp Leu His Glu Ala Val Pro Thr Val 
    50                  55                  60                  


Val Gly Ile Pro Asp Gly Thr Ala Val Val Gly Arg Ser Phe Arg Val 
65                  70                  75                  80  


Thr Ile Pro Thr Asp Leu Ile Ala Ser Ser Gly Asp Ile Ile Lys Val 
                85                  90                  95      


Ser Ala Ala Gly Lys Glu Ala Leu Pro Ser Trp Leu His Trp Asp Ser 
            100                 105                 110         


Gln Ser His Thr Leu Glu Gly Leu Pro Leu Asp Thr Asp Lys Gly Val 
        115                 120                 125             


His Tyr Ile Ser Val Ser Ala Thr Arg Leu Gly Ala Asn Gly Ser His 
    130                 135                 140                 


Ile Pro Gln Thr Ser Ser Val Phe Ser Ile Glu Val Tyr Pro Glu Asp 
145                 150                 155                 160 


His Ser Glu Leu Gln Ser Val Arg Thr Ala Ser Pro Asp Pro Gly Glu 
                165                 170                 175     


Val Val Ser Ser Ala Cys Ala Ala Asp Glu Pro Val Thr Val Leu Thr 
            180                 185                 190         


Val Ile Leu Asp Ala Asp Leu Thr Lys Met Thr Pro Lys Gln Arg Ile 
        195                 200                 205             


Asp Leu Leu His Arg Met Arg Ser Phe Ser Glu Val Glu Leu His Asn 
    210                 215                 220                 


Met Lys Leu Val Pro Val Val Asn Asn Arg Leu Phe Asp Met Ser Ala 
225                 230                 235                 240 


Phe Met Ala Gly Pro Gly Asn Ala Lys Lys Val Val Glu Asn Gly Ala 
                245                 250                 255     


Leu Leu Ser Trp Lys Leu Gly Cys Ser Leu Asn Gln Asn Ser Val Pro 
            260                 265                 270         


Asp Ile His Gly Val Glu Ala Pro Ala Arg Glu Gly Ala Met Ser Ala 
        275                 280                 285             


Gln Leu Gly Tyr Pro Val Val Gly Trp His Ile Ala Asn Lys Lys Pro 
    290                 295                 300                 


Pro Leu Pro Lys Arg Val Arg Arg Gln Ile His Ala Thr Pro Thr Pro 
305                 310                 315                 320 


Val Thr Ala Ile Gly Pro Pro Thr Thr Ala Ile Gln Glu Pro Pro Ser 
                325                 330                 335     


Arg Ile Val Pro Thr Pro Thr Ser Pro Ala Ile Ala Pro Pro Thr Glu 
            340                 345                 350         


Thr Met Ala Pro Pro Val Arg Asp Pro Val Pro Gly Lys Pro Thr Val 
        355                 360                 365             


Thr Ile Arg Thr Arg Gly Ala Ile Ile Gln Thr Pro Thr Leu Gly Pro 
    370                 375                 380                 


Ile Gln Pro Thr Arg Val Ser Glu Ala Gly Thr Thr Val Pro Gly Gln 
385                 390                 395                 400 


Ile Arg Pro Thr Met Thr Ile Pro Gly Tyr Val Glu Pro Thr Ala Val 
                405                 410                 415     


Ala Thr Pro Pro Thr Thr Thr Thr Lys Lys Pro Arg Val Ser Thr Pro 
            420                 425                 430         


Lys Pro Ala Thr Pro Ser Thr Asp Ser Thr Thr Thr Thr Thr Arg Arg 
        435                 440                 445             


Pro Thr Lys Lys Pro Arg Thr Pro Arg Pro Val Pro Arg Val Thr Thr 
    450                 455                 460                 


Lys Val Ser Ile Thr Arg Leu Glu Thr Ala Ser Pro Pro Thr Arg Ile 
465                 470                 475                 480 


Arg Thr Thr Thr Ser Gly Val Pro Arg Gly Gly Glu Pro Asn Gln Arg 
                485                 490                 495     


Pro Glu Leu Lys Asn His Ile Asp Arg Val Asp Ala Trp Val Gly Thr 
            500                 505                 510         


Tyr Phe Glu Val Lys Ile Pro Ser Asp Thr Phe Tyr Asp His Glu Asp 
        515                 520                 525             


Thr Thr Thr Asp Lys Leu Lys Leu Thr Leu Lys Leu Arg Glu Gln Gln 
    530                 535                 540                 


Leu Val Gly Glu Lys Ser Trp Val Gln Phe Asn Ser Asn Ser Gln Leu 
545                 550                 555                 560 


Met Tyr Gly Leu Pro Asp Ser Ser His Val Gly Lys His Glu Tyr Phe 
                565                 570                 575     


Met His Ala Thr Asp Lys Gly Gly Leu Ser Ala Val Asp Ala Phe Glu 
            580                 585                 590         


Ile His Val His Arg Arg Pro Gln Gly Asp Arg Ala Pro Ala Arg Phe 
        595                 600                 605             


Lys Ala Lys Phe Val Gly Asp Pro Ala Leu Val Leu Asn Asp Ile His 
    610                 615                 620                 


Lys Lys Ile Ala Leu Val Lys Lys Leu Ala Phe Ala Phe Gly Asp Arg 
625                 630                 635                 640 


Asn Cys Ser Thr Ile Thr Leu Gln Asn Ile Thr Arg Gly Ser Ile Val 
                645                 650                 655     


Val Glu Trp Thr Asn Asn Thr Leu Pro Leu Glu Pro Cys Pro Lys Glu 
            660                 665                 670         


Gln Ile Ala Gly Leu Ser Arg Arg Ile Ala Glu Asp Asp Gly Lys Pro 
        675                 680                 685             


Arg Pro Ala Phe Ser Asn Ala Leu Glu Pro Asp Phe Lys Ala Thr Ser 
    690                 695                 700                 


Ile Thr Val Thr Gly Ser Gly Ser Cys Arg His Leu Gln Phe Ile Pro 
705                 710                 715                 720 


Val Val Pro Pro Arg Arg Val Pro Ser Glu Ala Pro Pro Thr Glu Val 
                725                 730                 735     


Pro Asp Arg Asp Pro Glu Lys Ser Ser Glu Asp Asp Val Tyr Leu His 
            740                 745                 750         


Thr Val Ile Pro Ala Val Val Val Ala Ala Ile Leu Leu Ile Ala Gly 
        755                 760                 765             


Ile Ile Ala Met Ile Cys Tyr Arg Lys Lys Arg Lys Gly Lys Leu Thr 
    770                 775                 780                 


Leu Glu Asp Gln Ala Thr Phe Ile Lys Lys Gly Val Pro Ile Ile Phe 
785                 790                 795                 800 


Ala Asp Glu Leu Asp Asp Ser Lys Pro Pro Pro Ser Ser Ser Met Pro 
                805                 810                 815     


Leu Ile Leu Gln Glu Glu Lys Ala Pro Leu Pro Pro Pro Glu Tyr Pro 
            820                 825                 830         


Asn Gln Ser Val Pro Glu Thr Thr Pro Leu Asn Gln Asp Thr Met Gly 
        835                 840                 845             


Glu Tyr Thr Pro Leu Arg Asp Glu Asp Pro Asn Ala Pro Pro Tyr Gln 
    850                 855                 860                 


Pro Pro Pro Pro Phe Thr Ala Pro Met Glu Gly Lys Gly Ser Arg Pro 
865                 870                 875                 880 


Lys Asn Met Thr Pro Tyr Arg Ser Pro Pro Pro Tyr Val Pro Pro 
                885                 890                 895 


<210>  3040
<211>  540
<212>  PRT
<213>  Homo sapiens

<400>  3040

Met Gly Thr Thr Ala Arg Ala Ala Leu Val Leu Thr Tyr Leu Ala Val 
1               5                   10                  15      


Ala Ser Ala Ala Ser Glu Gly Gly Phe Thr Ala Thr Gly Gln Arg Gln 
            20                  25                  30          


Leu Arg Pro Glu His Phe Gln Glu Val Gly Tyr Ala Ala Pro Pro Ser 
        35                  40                  45              


Pro Pro Leu Ser Arg Ser Leu Pro Met Asp His Pro Asp Ser Ser Gln 
    50                  55                  60                  


His Gly Pro Pro Phe Glu Gly Gln Ser Gln Val Gln Pro Pro Pro Ser 
65                  70                  75                  80  


Gln Glu Ala Thr Pro Leu Gln Gln Glu Lys Leu Leu Pro Ala Gln Leu 
                85                  90                  95      


Pro Ala Glu Lys Glu Val Gly Pro Pro Leu Pro Gln Glu Ala Val Pro 
            100                 105                 110         


Leu Gln Lys Glu Leu Pro Ser Leu Gln His Pro Asn Glu Gln Lys Glu 
        115                 120                 125             


Gly Thr Pro Ala Pro Phe Gly Asp Gln Ser His Pro Glu Pro Glu Ser 
    130                 135                 140                 


Trp Asn Ala Ala Gln His Cys Gln Gln Asp Arg Ser Gln Gly Gly Trp 
145                 150                 155                 160 


Gly His Arg Leu Asp Gly Phe Pro Pro Gly Arg Pro Ser Pro Asp Asn 
                165                 170                 175     


Leu Asn Gln Ile Cys Leu Pro Asn Arg Gln His Val Val Tyr Gly Pro 
            180                 185                 190         


Trp Asn Leu Pro Gln Ser Ser Tyr Ser His Leu Thr Arg Gln Gly Glu 
        195                 200                 205             


Thr Leu Asn Phe Leu Glu Ile Gly Tyr Ser Arg Cys Cys His Cys Arg 
    210                 215                 220                 


Ser His Thr Asn Arg Leu Glu Cys Ala Lys Leu Val Trp Glu Glu Ala 
225                 230                 235                 240 


Met Ser Arg Phe Cys Glu Ala Glu Phe Ser Val Lys Thr Arg Pro His 
                245                 250                 255     


Trp Cys Cys Thr Arg Gln Gly Glu Ala Arg Phe Ser Cys Phe Gln Glu 
            260                 265                 270         


Glu Ala Pro Gln Pro His Tyr Gln Leu Arg Ala Cys Pro Ser His Gln 
        275                 280                 285             


Pro Asp Ile Ser Ser Gly Leu Glu Leu Pro Phe Pro Pro Gly Val Pro 
    290                 295                 300                 


Thr Leu Asp Asn Ile Lys Asn Ile Cys His Leu Arg Arg Phe Arg Ser 
305                 310                 315                 320 


Val Pro Arg Asn Leu Pro Ala Thr Asp Pro Leu Gln Arg Glu Leu Leu 
                325                 330                 335     


Ala Leu Ile Gln Leu Glu Arg Glu Phe Gln Arg Cys Cys Arg Gln Gly 
            340                 345                 350         


Asn Asn His Thr Cys Thr Trp Lys Ala Trp Glu Asp Thr Leu Asp Lys 
        355                 360                 365             


Tyr Cys Asp Arg Glu Tyr Ala Val Lys Thr His His His Leu Cys Cys 
    370                 375                 380                 


Arg His Pro Pro Ser Pro Thr Arg Asp Glu Cys Phe Ala Arg Arg Ala 
385                 390                 395                 400 


Pro Tyr Pro Asn Tyr Asp Arg Asp Ile Leu Thr Ile Asp Ile Gly Arg 
                405                 410                 415     


Val Thr Pro Asn Leu Met Gly His Leu Cys Gly Asn Gln Arg Val Leu 
            420                 425                 430         


Thr Lys His Lys His Ile Pro Gly Leu Ile His Asn Met Thr Ala Arg 
        435                 440                 445             


Cys Cys Asp Leu Pro Phe Pro Glu Gln Ala Cys Cys Ala Glu Glu Glu 
    450                 455                 460                 


Lys Leu Thr Phe Ile Asn Asp Leu Cys Gly Pro Arg Arg Asn Ile Trp 
465                 470                 475                 480 


Arg Asp Pro Ala Leu Cys Cys Tyr Leu Ser Pro Gly Asp Glu Gln Val 
                485                 490                 495     


Asn Cys Phe Asn Ile Asn Tyr Leu Arg Asn Val Ala Leu Val Ser Gly 
            500                 505                 510         


Asp Thr Glu Asn Ala Lys Gly Gln Gly Glu Gln Gly Ser Thr Gly Gly 
        515                 520                 525             


Thr Asn Ile Ser Ser Thr Ser Glu Pro Lys Glu Glu 
    530                 535                 540 


<210>  3041
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  3041

Met Ala Arg Pro Gly Gln Arg Trp Leu Gly Lys Trp Leu Val Ala Met 
1               5                   10                  15      


Val Val Trp Ala Leu Cys Arg Leu Ala Thr Pro Leu Ala Lys Asn Leu 
            20                  25                  30          


Glu Pro Val Ser Trp Ser Ser Leu Asn Pro Lys Phe Leu Ser Gly Lys 
        35                  40                  45              


Gly Leu Val Ile Tyr Pro Lys Ile Gly Asp Lys Leu Asp Ile Ile Cys 
    50                  55                  60                  


Pro Arg Ala Glu Ala Gly Arg Pro Tyr Glu Tyr Tyr Lys Leu Tyr Leu 
65                  70                  75                  80  


Val Arg Pro Glu Gln Ala Ala Ala Cys Ser Thr Val Leu Asp Pro Asn 
                85                  90                  95      


Val Leu Val Thr Cys Asn Arg Pro Glu Gln Glu Ile Arg Phe Thr Ile 
            100                 105                 110         


Lys Phe Gln Glu Phe Ser Pro Asn Tyr Met Gly Leu Glu Phe Lys Lys 
        115                 120                 125             


His His Asp Tyr Tyr Ile Thr Ser Thr Ser Asn Gly Ser Leu Glu Gly 
    130                 135                 140                 


Leu Glu Asn Arg Glu Gly Gly Val Cys Arg Thr Arg Thr Met Lys Ile 
145                 150                 155                 160 


Ile Met Lys Val Gly Gln Asp Pro Asn Ala Val Thr Pro Glu Gln Leu 
                165                 170                 175     


Thr Thr Ser Arg Pro Ser Lys Glu Ala Asp Asn Thr Val Lys Met Ala 
            180                 185                 190         


Thr Gln Ala Pro Gly Ser Arg Gly Ser Leu Gly Asp Ser Asp Gly Lys 
        195                 200                 205             


His Glu Thr Val Asn Gln Glu Glu Lys Ser Gly Pro Gly Ala Ser Gly 
    210                 215                 220                 


Gly Ser Ser Gly Asp Pro Asp Gly Phe Phe Asn Ser Lys Val Ala Leu 
225                 230                 235                 240 


Phe Ala Ala Val Gly Ala Gly Cys Val Ile Phe Leu Leu Ile Ile Ile 
                245                 250                 255     


Phe Leu Thr Val Leu Leu Leu Lys Leu Arg Lys Arg His Arg Lys His 
            260                 265                 270         


Thr Gln Gln Arg Ala Ala Ala Leu Ser Leu Ser Thr Leu Ala Ser Pro 
        275                 280                 285             


Lys Gly Gly Ser Gly Thr Ala Gly Thr Glu Pro Ser Asp Ile Ile Ile 
    290                 295                 300                 


Pro Leu Arg Thr Thr Glu Asn Asn Tyr Cys Pro His Tyr Glu Lys Val 
305                 310                 315                 320 


Ser Gly Asp Tyr Gly His Pro Val Tyr Ile Val Gln Glu Met Pro Pro 
                325                 330                 335     


Gln Ser Pro Ala Asn Ile Tyr Tyr Lys Val 
            340                 345     


<210>  3042
<211>  976
<212>  PRT
<213>  Homo sapiens

<400>  3042

Met Glu Leu Gln Ala Ala Arg Ala Cys Phe Ala Leu Leu Trp Gly Cys 
1               5                   10                  15      


Ala Leu Ala Ala Ala Ala Ala Ala Gln Gly Lys Glu Val Val Leu Leu 
            20                  25                  30          


Asp Phe Ala Ala Ala Gly Gly Glu Leu Gly Trp Leu Thr His Pro Tyr 
        35                  40                  45              


Gly Lys Gly Trp Asp Leu Met Gln Asn Ile Met Asn Asp Met Pro Ile 
    50                  55                  60                  


Tyr Met Tyr Ser Val Cys Asn Val Met Ser Gly Asp Gln Asp Asn Trp 
65                  70                  75                  80  


Leu Arg Thr Asn Trp Val Tyr Arg Gly Glu Ala Glu Arg Ile Phe Ile 
                85                  90                  95      


Glu Leu Lys Phe Thr Val Arg Asp Cys Asn Ser Phe Pro Gly Gly Ala 
            100                 105                 110         


Ser Ser Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Ala Glu Ser Asp Leu 
        115                 120                 125             


Asp Tyr Gly Thr Asn Phe Gln Lys Arg Leu Phe Thr Lys Ile Asp Thr 
    130                 135                 140                 


Ile Ala Pro Asp Glu Ile Thr Val Ser Ser Asp Phe Glu Ala Arg His 
145                 150                 155                 160 


Val Lys Leu Asn Val Glu Glu Arg Ser Val Gly Pro Leu Thr Arg Lys 
                165                 170                 175     


Gly Phe Tyr Leu Ala Phe Gln Asp Ile Gly Ala Cys Val Ala Leu Leu 
            180                 185                 190         


Ser Val Arg Val Tyr Tyr Lys Lys Cys Pro Glu Leu Leu Gln Gly Leu 
        195                 200                 205             


Ala His Phe Pro Glu Thr Ile Ala Gly Ser Asp Ala Pro Ser Leu Ala 
    210                 215                 220                 


Thr Val Ala Gly Thr Cys Val Asp His Ala Val Val Pro Pro Gly Gly 
225                 230                 235                 240 


Glu Glu Pro Arg Met His Cys Ala Val Asp Gly Glu Trp Leu Val Pro 
                245                 250                 255     


Ile Gly Gln Cys Leu Cys Gln Ala Gly Tyr Glu Lys Val Glu Asp Ala 
            260                 265                 270         


Cys Gln Ala Cys Ser Pro Gly Phe Phe Lys Phe Glu Ala Ser Glu Ser 
        275                 280                 285             


Pro Cys Leu Glu Cys Pro Glu His Thr Leu Pro Ser Pro Glu Gly Ala 
    290                 295                 300                 


Thr Ser Cys Glu Cys Glu Glu Gly Phe Phe Arg Ala Pro Gln Asp Pro 
305                 310                 315                 320 


Ala Ser Met Pro Cys Thr Arg Pro Pro Ser Ala Pro His Tyr Leu Thr 
                325                 330                 335     


Ala Val Gly Met Gly Ala Lys Val Glu Leu Arg Trp Thr Pro Pro Gln 
            340                 345                 350         


Asp Ser Gly Gly Arg Glu Asp Ile Val Tyr Ser Val Thr Cys Glu Gln 
        355                 360                 365             


Cys Trp Pro Glu Ser Gly Glu Cys Gly Pro Cys Glu Ala Ser Val Arg 
    370                 375                 380                 


Tyr Ser Glu Pro Pro His Gly Leu Thr Arg Thr Ser Val Thr Val Ser 
385                 390                 395                 400 


Asp Leu Glu Pro His Met Asn Tyr Thr Phe Thr Val Glu Ala Arg Asn 
                405                 410                 415     


Gly Val Ser Gly Leu Val Thr Ser Arg Ser Phe Arg Thr Ala Ser Val 
            420                 425                 430         


Ser Ile Asn Gln Thr Glu Pro Pro Lys Val Arg Leu Glu Gly Arg Ser 
        435                 440                 445             


Thr Thr Ser Leu Ser Val Ser Trp Ser Ile Pro Pro Pro Gln Gln Ser 
    450                 455                 460                 


Arg Val Trp Lys Tyr Glu Val Thr Tyr Arg Lys Lys Gly Asp Ser Asn 
465                 470                 475                 480 


Ser Tyr Asn Val Arg Arg Thr Glu Gly Phe Ser Val Thr Leu Asp Asp 
                485                 490                 495     


Leu Ala Pro Asp Thr Thr Tyr Leu Val Gln Val Gln Ala Leu Thr Gln 
            500                 505                 510         


Glu Gly Gln Gly Ala Gly Ser Lys Val His Glu Phe Gln Thr Leu Ser 
        515                 520                 525             


Pro Glu Gly Ser Gly Asn Leu Ala Val Ile Gly Gly Val Ala Val Gly 
    530                 535                 540                 


Val Val Leu Leu Leu Val Leu Ala Gly Val Gly Phe Phe Ile His Arg 
545                 550                 555                 560 


Arg Arg Lys Asn Gln Arg Ala Arg Gln Ser Pro Glu Asp Val Tyr Phe 
                565                 570                 575     


Ser Lys Ser Glu Gln Leu Lys Pro Leu Lys Thr Tyr Val Asp Pro His 
            580                 585                 590         


Thr Tyr Glu Asp Pro Asn Gln Ala Val Leu Lys Phe Thr Thr Glu Ile 
        595                 600                 605             


His Pro Ser Cys Val Thr Arg Gln Lys Val Ile Gly Ala Gly Glu Phe 
    610                 615                 620                 


Gly Glu Val Tyr Lys Gly Met Leu Lys Thr Ser Ser Gly Lys Lys Glu 
625                 630                 635                 640 


Val Pro Val Ala Ile Lys Thr Leu Lys Ala Gly Tyr Thr Glu Lys Gln 
                645                 650                 655     


Arg Val Asp Phe Leu Gly Glu Ala Gly Ile Met Gly Gln Phe Ser His 
            660                 665                 670         


His Asn Ile Ile Arg Leu Glu Gly Val Ile Ser Lys Tyr Lys Pro Met 
        675                 680                 685             


Met Ile Ile Thr Glu Tyr Met Glu Asn Gly Ala Leu Asp Lys Phe Leu 
    690                 695                 700                 


Arg Glu Lys Asp Gly Glu Phe Ser Val Leu Gln Leu Val Gly Met Leu 
705                 710                 715                 720 


Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ala Asn Met Asn Tyr Val 
                725                 730                 735     


His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn Leu Val 
            740                 745                 750         


Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val Leu Glu Asp Asp Pro 
        755                 760                 765             


Glu Ala Thr Tyr Thr Thr Ser Gly Gly Lys Ile Pro Ile Arg Trp Thr 
    770                 775                 780                 


Ala Pro Glu Ala Ile Ser Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val 
785                 790                 795                 800 


Trp Ser Phe Gly Ile Val Met Trp Glu Val Met Thr Tyr Gly Glu Arg 
                805                 810                 815     


Pro Tyr Trp Glu Leu Ser Asn His Glu Val Met Lys Ala Ile Asn Asp 
            820                 825                 830         


Gly Phe Arg Leu Pro Thr Pro Met Asp Cys Pro Ser Ala Ile Tyr Gln 
        835                 840                 845             


Leu Met Met Gln Cys Trp Gln Gln Glu Arg Ala Arg Arg Pro Lys Phe 
    850                 855                 860                 


Ala Asp Ile Val Ser Ile Leu Asp Lys Leu Ile Arg Ala Pro Asp Ser 
865                 870                 875                 880 


Leu Lys Thr Leu Ala Asp Phe Asp Pro Arg Val Ser Ile Arg Leu Pro 
                885                 890                 895     


Ser Thr Ser Gly Ser Glu Gly Val Pro Phe Arg Thr Val Ser Glu Trp 
            900                 905                 910         


Leu Glu Ser Ile Lys Met Gln Gln Tyr Thr Glu His Phe Met Ala Ala 
        915                 920                 925             


Gly Tyr Thr Ala Ile Glu Lys Val Val Gln Met Thr Asn Asp Asp Ile 
    930                 935                 940                 


Lys Arg Ile Gly Val Arg Leu Pro Gly His Gln Lys Arg Ile Ala Tyr 
945                 950                 955                 960 


Ser Leu Leu Gly Leu Lys Asp Gln Val Asn Thr Val Gly Ile Pro Ile 
                965                 970                 975     


<210>  3043
<211>  986
<212>  PRT
<213>  Homo sapiens

<400>  3043

Met Ala Gly Ile Phe Tyr Phe Ala Leu Phe Ser Cys Leu Phe Gly Ile 
1               5                   10                  15      


Cys Asp Ala Val Thr Gly Ser Arg Val Tyr Pro Ala Asn Glu Val Thr 
            20                  25                  30          


Leu Leu Asp Ser Arg Ser Val Gln Gly Glu Leu Gly Trp Ile Ala Ser 
        35                  40                  45              


Pro Leu Glu Gly Gly Trp Glu Glu Val Ser Ile Met Asp Glu Lys Asn 
    50                  55                  60                  


Thr Pro Ile Arg Thr Tyr Gln Val Cys Asn Val Met Glu Pro Ser Gln 
65                  70                  75                  80  


Asn Asn Trp Leu Arg Thr Asp Trp Ile Thr Arg Glu Gly Ala Gln Arg 
                85                  90                  95      


Val Tyr Ile Glu Ile Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu Pro 
            100                 105                 110         


Gly Val Met Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr Glu 
        115                 120                 125             


Ser Asp Asn Asp Lys Glu Arg Phe Ile Arg Glu Asn Gln Phe Val Lys 
    130                 135                 140                 


Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Val Asp Ile Gly 
145                 150                 155                 160 


Asp Arg Ile Met Lys Leu Asn Thr Glu Ile Arg Asp Val Gly Pro Leu 
                165                 170                 175     


Ser Lys Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys Ile 
            180                 185                 190         


Ala Leu Val Ser Val Arg Val Phe Tyr Lys Lys Cys Pro Leu Thr Val 
        195                 200                 205             


Arg Asn Leu Ala Gln Phe Pro Asp Thr Ile Thr Gly Ala Asp Thr Ser 
    210                 215                 220                 


Ser Leu Val Glu Val Arg Gly Ser Cys Val Asn Asn Ser Glu Glu Lys 
225                 230                 235                 240 


Asp Val Pro Lys Met Tyr Cys Gly Ala Asp Gly Glu Trp Leu Val Pro 
                245                 250                 255     


Ile Gly Asn Cys Leu Cys Asn Ala Gly His Glu Glu Arg Ser Gly Glu 
            260                 265                 270         


Cys Gln Ala Cys Lys Ile Gly Tyr Tyr Lys Ala Leu Ser Thr Asp Ala 
        275                 280                 285             


Thr Cys Ala Lys Cys Pro Pro His Ser Tyr Ser Val Trp Glu Gly Ala 
    290                 295                 300                 


Thr Ser Cys Thr Cys Asp Arg Gly Phe Phe Arg Ala Asp Asn Asp Ala 
305                 310                 315                 320 


Ala Ser Met Pro Cys Thr Arg Pro Pro Ser Ala Pro Leu Asn Leu Ile 
                325                 330                 335     


Ser Asn Val Asn Glu Thr Ser Val Asn Leu Glu Trp Ser Ser Pro Gln 
            340                 345                 350         


Asn Thr Gly Gly Arg Gln Asp Ile Ser Tyr Asn Val Val Cys Lys Lys 
        355                 360                 365             


Cys Gly Ala Gly Asp Pro Ser Lys Cys Arg Pro Cys Gly Ser Gly Val 
    370                 375                 380                 


His Tyr Thr Pro Gln Gln Asn Gly Leu Lys Thr Thr Lys Val Ser Ile 
385                 390                 395                 400 


Thr Asp Leu Leu Ala His Thr Asn Tyr Thr Phe Glu Ile Trp Ala Val 
                405                 410                 415     


Asn Gly Val Ser Lys Tyr Asn Pro Asn Pro Asp Gln Ser Val Ser Val 
            420                 425                 430         


Thr Val Thr Thr Asn Gln Ala Ala Pro Ser Ser Ile Ala Leu Val Gln 
        435                 440                 445             


Ala Lys Glu Val Thr Arg Tyr Ser Val Ala Leu Ala Trp Leu Glu Pro 
    450                 455                 460                 


Asp Arg Pro Asn Gly Val Ile Leu Glu Tyr Glu Val Lys Tyr Tyr Glu 
465                 470                 475                 480 


Lys Asp Gln Asn Glu Arg Ser Tyr Arg Ile Val Arg Thr Ala Ala Arg 
                485                 490                 495     


Asn Thr Asp Ile Lys Gly Leu Asn Pro Leu Thr Ser Tyr Val Phe His 
            500                 505                 510         


Val Arg Ala Arg Thr Ala Ala Gly Tyr Gly Asp Phe Ser Glu Pro Leu 
        515                 520                 525             


Glu Val Thr Thr Asn Thr Val Pro Ser Arg Ile Ile Gly Asp Gly Ala 
    530                 535                 540                 


Asn Ser Thr Val Leu Leu Val Ser Val Ser Gly Ser Val Val Leu Val 
545                 550                 555                 560 


Val Ile Leu Ile Ala Ala Phe Val Ile Ser Arg Arg Arg Ser Lys Tyr 
                565                 570                 575     


Ser Lys Ala Lys Gln Glu Ala Asp Glu Glu Lys His Leu Asn Gln Gly 
            580                 585                 590         


Val Arg Thr Tyr Val Asp Pro Phe Thr Tyr Glu Asp Pro Asn Gln Ala 
        595                 600                 605             


Val Arg Glu Phe Ala Lys Glu Ile Asp Ala Ser Cys Ile Lys Ile Glu 
    610                 615                 620                 


Lys Val Ile Gly Val Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu 
625                 630                 635                 640 


Lys Val Pro Gly Lys Arg Glu Ile Cys Val Ala Ile Lys Thr Leu Lys 
                645                 650                 655     


Ala Gly Tyr Thr Asp Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser 
            660                 665                 670         


Ile Met Gly Gln Phe Asp His Pro Asn Ile Ile His Leu Glu Gly Val 
        675                 680                 685             


Val Thr Lys Cys Lys Pro Val Met Ile Ile Thr Glu Tyr Met Glu Asn 
    690                 695                 700                 


Gly Ser Leu Asp Ala Phe Leu Arg Lys Asn Asp Gly Arg Phe Thr Val 
705                 710                 715                 720 


Ile Gln Leu Val Gly Met Leu Arg Gly Ile Gly Ser Gly Met Lys Tyr 
                725                 730                 735     


Leu Ser Asp Met Ser Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile 
            740                 745                 750         


Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Met Ser 
        755                 760                 765             


Arg Val Leu Glu Asp Asp Pro Glu Ala Ala Tyr Thr Thr Arg Gly Gly 
    770                 775                 780                 


Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys 
785                 790                 795                 800 


Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu 
                805                 810                 815     


Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp 
            820                 825                 830         


Val Ile Lys Ala Ile Glu Glu Gly Tyr Arg Leu Pro Pro Pro Met Asp 
        835                 840                 845             


Cys Pro Ile Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Glu 
    850                 855                 860                 


Arg Ser Asp Arg Pro Lys Phe Gly Gln Ile Val Asn Met Leu Asp Lys 
865                 870                 875                 880 


Leu Ile Arg Asn Pro Asn Ser Leu Lys Arg Thr Gly Thr Glu Ser Ser 
                885                 890                 895     


Arg Pro Asn Thr Ala Leu Leu Asp Pro Ser Ser Pro Glu Phe Ser Ala 
            900                 905                 910         


Val Val Ser Val Gly Asp Trp Leu Gln Ala Ile Lys Met Asp Arg Tyr 
        915                 920                 925             


Lys Asp Asn Phe Thr Ala Ala Gly Tyr Thr Thr Leu Glu Ala Val Val 
    930                 935                 940                 


His Val Asn Gln Glu Asp Leu Ala Arg Ile Gly Ile Thr Ala Ile Thr 
945                 950                 955                 960 


His Gln Asn Lys Ile Leu Ser Ser Val Gln Ala Met Arg Thr Gln Met 
                965                 970                 975     


Gln Gln Met His Gly Arg Met Val Pro Val 
            980                 985     


<210>  3044
<211>  1037
<212>  PRT
<213>  Homo sapiens

<400>  3044

Met Arg Gly Ser Gly Pro Arg Gly Ala Gly Arg Arg Arg Pro Pro Ser 
1               5                   10                  15      


Gly Gly Gly Asp Thr Pro Ile Thr Pro Ala Ser Leu Ala Gly Cys Tyr 
            20                  25                  30          


Ser Ala Pro Arg Arg Ala Pro Leu Trp Thr Cys Leu Leu Leu Cys Ala 
        35                  40                  45              


Ala Leu Arg Thr Leu Leu Ala Ser Pro Ser Asn Glu Val Asn Leu Leu 
    50                  55                  60                  


Asp Ser Arg Thr Val Met Gly Asp Leu Gly Trp Ile Ala Phe Pro Lys 
65                  70                  75                  80  


Asn Gly Trp Glu Glu Ile Gly Glu Val Asp Glu Asn Tyr Ala Pro Ile 
                85                  90                  95      


His Thr Tyr Gln Val Cys Lys Val Met Glu Gln Asn Gln Asn Asn Trp 
            100                 105                 110         


Leu Leu Thr Ser Trp Ile Ser Asn Glu Gly Ala Ser Arg Ile Phe Ile 
        115                 120                 125             


Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu Pro Gly Gly Leu 
    130                 135                 140                 


Gly Thr Cys Lys Glu Thr Phe Asn Met Tyr Tyr Phe Glu Ser Asp Asp 
145                 150                 155                 160 


Gln Asn Gly Arg Asn Ile Lys Glu Asn Gln Tyr Ile Lys Ile Asp Thr 
                165                 170                 175     


Ile Ala Ala Asp Glu Ser Phe Thr Glu Leu Asp Leu Gly Asp Arg Val 
            180                 185                 190         


Met Lys Leu Asn Thr Glu Val Arg Asp Val Gly Pro Leu Ser Lys Lys 
        195                 200                 205             


Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys Ile Ala Leu Val 
    210                 215                 220                 


Ser Val Arg Val Tyr Tyr Lys Lys Cys Pro Ser Val Val Arg His Leu 
225                 230                 235                 240 


Ala Val Phe Pro Asp Thr Ile Thr Gly Ala Asp Ser Ser Gln Leu Leu 
                245                 250                 255     


Glu Val Ser Gly Ser Cys Val Asn His Ser Val Thr Asp Glu Pro Pro 
            260                 265                 270         


Lys Met His Cys Ser Ala Glu Gly Glu Trp Leu Val Pro Ile Gly Lys 
        275                 280                 285             


Cys Met Cys Lys Ala Gly Tyr Glu Glu Lys Asn Gly Thr Cys Gln Val 
    290                 295                 300                 


Cys Arg Pro Gly Phe Phe Lys Ala Ser Pro His Ile Gln Ser Cys Gly 
305                 310                 315                 320 


Lys Cys Pro Pro His Ser Tyr Thr His Glu Glu Ala Ser Thr Ser Cys 
                325                 330                 335     


Val Cys Glu Lys Asp Tyr Phe Arg Arg Glu Ser Asp Pro Pro Thr Met 
            340                 345                 350         


Ala Cys Thr Arg Pro Pro Ser Ala Pro Arg Asn Ala Ile Ser Asn Val 
        355                 360                 365             


Asn Glu Thr Ser Val Phe Leu Glu Trp Ile Pro Pro Ala Asp Thr Gly 
    370                 375                 380                 


Gly Arg Lys Asp Val Ser Tyr Tyr Ile Ala Cys Lys Lys Cys Asn Ser 
385                 390                 395                 400 


His Ala Gly Val Cys Glu Glu Cys Gly Gly His Val Arg Tyr Leu Pro 
                405                 410                 415     


Arg Gln Ser Gly Leu Lys Asn Thr Ser Val Met Met Val Asp Leu Leu 
            420                 425                 430         


Ala His Thr Asn Tyr Thr Phe Glu Ile Glu Ala Val Asn Gly Val Ser 
        435                 440                 445             


Asp Leu Ser Pro Gly Ala Arg Gln Tyr Val Ser Val Asn Val Thr Thr 
    450                 455                 460                 


Asn Gln Ala Ala Pro Ser Pro Val Thr Asn Val Lys Lys Gly Lys Ile 
465                 470                 475                 480 


Ala Lys Asn Ser Ile Ser Leu Ser Trp Gln Glu Pro Asp Arg Pro Asn 
                485                 490                 495     


Gly Ile Ile Leu Glu Tyr Glu Ile Lys Tyr Phe Glu Lys Asp Gln Glu 
            500                 505                 510         


Thr Ser Tyr Thr Ile Ile Lys Ser Lys Glu Thr Thr Ile Thr Ala Glu 
        515                 520                 525             


Gly Leu Lys Pro Ala Ser Val Tyr Val Phe Gln Ile Arg Ala Arg Thr 
    530                 535                 540                 


Ala Ala Gly Tyr Gly Val Phe Ser Arg Arg Phe Glu Phe Glu Thr Thr 
545                 550                 555                 560 


Pro Val Phe Ala Ala Ser Ser Asp Gln Ser Gln Ile Pro Val Ile Ala 
                565                 570                 575     


Val Ser Val Thr Val Gly Val Ile Leu Leu Ala Val Val Ile Gly Val 
            580                 585                 590         


Leu Leu Ser Gly Ser Cys Cys Glu Cys Gly Cys Gly Arg Ala Ser Ser 
        595                 600                 605             


Leu Cys Ala Val Ala His Pro Ser Leu Ile Trp Arg Cys Gly Tyr Ser 
    610                 615                 620                 


Lys Ala Lys Gln Asp Pro Glu Glu Glu Lys Met His Phe His Asn Gly 
625                 630                 635                 640 


His Ile Lys Leu Pro Gly Val Arg Thr Tyr Ile Asp Pro His Thr Tyr 
                645                 650                 655     


Glu Asp Pro Asn Gln Ala Val His Glu Phe Ala Lys Glu Ile Glu Ala 
            660                 665                 670         


Ser Cys Ile Thr Ile Glu Arg Val Ile Gly Ala Gly Glu Phe Gly Glu 
        675                 680                 685             


Val Cys Ser Gly Arg Leu Lys Leu Pro Gly Lys Arg Glu Leu Pro Val 
    690                 695                 700                 


Ala Ile Lys Thr Leu Lys Val Gly Tyr Thr Glu Lys Gln Arg Arg Asp 
705                 710                 715                 720 


Phe Leu Gly Glu Ala Ser Ile Met Gly Gln Phe Asp His Pro Asn Ile 
                725                 730                 735     


Ile His Leu Glu Gly Val Val Thr Lys Ser Lys Pro Val Met Ile Val 
            740                 745                 750         


Thr Glu Tyr Met Glu Asn Gly Ser Leu Asp Thr Phe Leu Lys Lys Asn 
        755                 760                 765             


Asp Gly Gln Phe Thr Val Ile Gln Leu Val Gly Met Leu Arg Gly Ile 
    770                 775                 780                 


Ser Ala Gly Met Lys Tyr Leu Ser Asp Met Gly Tyr Val His Arg Asp 
785                 790                 795                 800 


Leu Ala Ala Arg Asn Ile Leu Ile Asn Ser Asn Leu Val Cys Lys Val 
                805                 810                 815     


Ser Asp Phe Gly Leu Ser Arg Val Leu Glu Asp Asp Pro Glu Ala Ala 
            820                 825                 830         


Tyr Thr Thr Arg Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu 
        835                 840                 845             


Ala Ile Ala Phe Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr 
    850                 855                 860                 


Gly Ile Val Met Trp Glu Val Val Ser Tyr Gly Glu Arg Pro Tyr Trp 
865                 870                 875                 880 


Glu Met Thr Asn Gln Asp Val Ile Lys Ala Val Glu Glu Gly Tyr Arg 
                885                 890                 895     


Leu Pro Ser Pro Met Asp Cys Pro Ala Ala Leu Tyr Gln Leu Met Leu 
            900                 905                 910         


Asp Cys Trp Gln Lys Glu Arg Asn Ser Arg Pro Lys Phe Asp Glu Ile 
        915                 920                 925             


Val Asn Met Leu Asp Lys Leu Ile Arg Asn Pro Ser Ser Leu Lys Thr 
    930                 935                 940                 


Leu Val Asn Ala Ser Cys Arg Val Ser Asn Leu Leu Ala Glu His Ser 
945                 950                 955                 960 


Pro Leu Gly Ser Gly Ala Tyr Arg Ser Val Gly Glu Trp Leu Glu Ala 
                965                 970                 975     


Ile Lys Met Gly Arg Tyr Thr Glu Ile Phe Met Glu Asn Gly Tyr Ser 
            980                 985                 990         


Ser Met Asp Ala Val Ala Gln Val  Thr Leu Glu Asp Leu  Arg Arg Leu 
        995                 1000                 1005             


Gly Val  Thr Leu Val Gly His  Gln Lys Lys Ile Met  Asn Ser Leu 
    1010                 1015                 1020             


Gln Glu  Met Lys Val Gln Leu  Val Asn Gly Met Val  Pro Leu 
    1025                 1030                 1035         


<210>  3045
<211>  998
<212>  PRT
<213>  Homo sapiens

<400>  3045

Met Val Phe Gln Thr Arg Tyr Pro Ser Trp Ile Ile Leu Cys Tyr Ile 
1               5                   10                  15      


Trp Leu Leu Arg Phe Ala His Thr Gly Glu Ala Gln Ala Ala Lys Glu 
            20                  25                  30          


Val Leu Leu Leu Asp Ser Lys Ala Gln Gln Thr Glu Leu Glu Trp Ile 
        35                  40                  45              


Ser Ser Pro Pro Asn Gly Trp Glu Glu Ile Ser Gly Leu Asp Glu Asn 
    50                  55                  60                  


Tyr Thr Pro Ile Arg Thr Tyr Gln Val Cys Gln Val Met Glu Pro Asn 
65                  70                  75                  80  


Gln Asn Asn Trp Leu Arg Thr Asn Trp Ile Ser Lys Gly Asn Ala Gln 
                85                  90                  95      


Arg Ile Phe Val Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu 
            100                 105                 110         


Pro Gly Val Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr 
        115                 120                 125             


Glu Thr Asp Tyr Asp Thr Gly Arg Asn Ile Arg Glu Asn Leu Tyr Val 
    130                 135                 140                 


Lys Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Gly Asp Leu 
145                 150                 155                 160 


Gly Glu Arg Lys Met Lys Leu Asn Thr Glu Val Arg Glu Ile Gly Pro 
                165                 170                 175     


Leu Ser Lys Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys 
            180                 185                 190         


Ile Ala Leu Val Ser Val Lys Val Tyr Tyr Lys Lys Cys Trp Ser Ile 
        195                 200                 205             


Ile Glu Asn Leu Ala Ile Phe Pro Asp Thr Val Thr Gly Ser Glu Phe 
    210                 215                 220                 


Ser Ser Leu Val Glu Val Arg Gly Thr Cys Val Ser Ser Ala Glu Glu 
225                 230                 235                 240 


Glu Ala Glu Asn Ala Pro Arg Met His Cys Ser Ala Glu Gly Glu Trp 
                245                 250                 255     


Leu Val Pro Ile Gly Lys Cys Ile Cys Lys Ala Gly Tyr Gln Gln Lys 
            260                 265                 270         


Gly Asp Thr Cys Glu Pro Cys Gly Arg Gly Phe Tyr Lys Ser Ser Ser 
        275                 280                 285             


Gln Asp Leu Gln Cys Ser Arg Cys Pro Thr His Ser Phe Ser Asp Lys 
    290                 295                 300                 


Glu Gly Ser Ser Arg Cys Glu Cys Glu Asp Gly Tyr Tyr Arg Ala Pro 
305                 310                 315                 320 


Ser Asp Pro Pro Tyr Val Ala Cys Thr Arg Pro Pro Ser Ala Pro Gln 
                325                 330                 335     


Asn Leu Ile Phe Asn Ile Asn Gln Thr Thr Val Ser Leu Glu Trp Ser 
            340                 345                 350         


Pro Pro Ala Asp Asn Gly Gly Arg Asn Asp Val Thr Tyr Arg Ile Leu 
        355                 360                 365             


Cys Lys Arg Cys Ser Trp Glu Gln Gly Glu Cys Val Pro Cys Gly Ser 
    370                 375                 380                 


Asn Ile Gly Tyr Met Pro Gln Gln Thr Gly Leu Glu Asp Asn Tyr Val 
385                 390                 395                 400 


Thr Val Met Asp Leu Leu Ala His Ala Asn Tyr Thr Phe Glu Val Glu 
                405                 410                 415     


Ala Val Asn Gly Val Ser Asp Leu Ser Arg Ser Gln Arg Leu Phe Ala 
            420                 425                 430         


Ala Val Ser Ile Thr Thr Gly Gln Ala Ala Pro Ser Gln Val Ser Gly 
        435                 440                 445             


Val Met Lys Glu Arg Val Leu Gln Arg Ser Val Glu Leu Ser Trp Gln 
    450                 455                 460                 


Glu Pro Glu His Pro Asn Gly Val Ile Thr Glu Tyr Glu Ile Lys Tyr 
465                 470                 475                 480 


Tyr Glu Lys Asp Gln Arg Glu Arg Thr Tyr Ser Thr Val Lys Thr Lys 
                485                 490                 495     


Ser Thr Ser Ala Ser Ile Asn Asn Leu Lys Pro Gly Thr Val Tyr Val 
            500                 505                 510         


Phe Gln Ile Arg Ala Phe Thr Ala Ala Gly Tyr Gly Asn Tyr Ser Pro 
        515                 520                 525             


Arg Leu Asp Val Ala Thr Leu Glu Glu Ala Thr Gly Lys Met Phe Glu 
    530                 535                 540                 


Ala Thr Ala Val Ser Ser Glu Gln Asn Pro Val Ile Ile Ile Ala Val 
545                 550                 555                 560 


Val Ala Val Ala Gly Thr Ile Ile Leu Val Phe Met Val Phe Gly Phe 
                565                 570                 575     


Ile Ile Gly Arg Arg His Cys Gly Tyr Ser Lys Ala Asp Gln Glu Gly 
            580                 585                 590         


Asp Glu Glu Leu Tyr Phe His Phe Lys Phe Pro Gly Thr Lys Thr Tyr 
        595                 600                 605             


Ile Asp Pro Glu Thr Tyr Glu Asp Pro Asn Arg Ala Val His Gln Phe 
    610                 615                 620                 


Ala Lys Glu Leu Asp Ala Ser Cys Ile Lys Ile Glu Arg Val Ile Gly 
625                 630                 635                 640 


Ala Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu Lys Leu Pro Gly 
                645                 650                 655     


Lys Arg Asp Val Ala Val Ala Ile Lys Thr Leu Lys Val Gly Tyr Thr 
            660                 665                 670         


Glu Lys Gln Arg Arg Asp Phe Leu Cys Glu Ala Ser Ile Met Gly Gln 
        675                 680                 685             


Phe Asp His Pro Asn Val Val His Leu Glu Gly Val Val Thr Arg Gly 
    690                 695                 700                 


Lys Pro Val Met Ile Val Ile Glu Phe Met Glu Asn Gly Ala Leu Asp 
705                 710                 715                 720 


Ala Phe Leu Arg Lys His Asp Gly Gln Phe Thr Val Ile Gln Leu Val 
                725                 730                 735     


Gly Met Leu Arg Gly Ile Ala Ala Gly Met Arg Tyr Leu Ala Asp Met 
            740                 745                 750         


Gly Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser 
        755                 760                 765             


Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val Ile Glu 
    770                 775                 780                 


Asp Asp Pro Glu Ala Val Tyr Thr Thr Thr Gly Gly Lys Ile Pro Val 
785                 790                 795                 800 


Arg Trp Thr Ala Pro Glu Ala Ile Gln Tyr Arg Lys Phe Thr Ser Ala 
                805                 810                 815     


Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu Val Met Ser Tyr 
            820                 825                 830         


Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp Val Ile Lys Ala 
        835                 840                 845             


Ile Glu Glu Gly Tyr Arg Leu Pro Ala Pro Met Asp Cys Pro Ala Gly 
    850                 855                 860                 


Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Glu Arg Ala Glu Arg 
865                 870                 875                 880 


Pro Lys Phe Glu Gln Ile Val Gly Ile Leu Asp Lys Met Ile Arg Asn 
                885                 890                 895     


Pro Asn Ser Leu Lys Thr Pro Leu Gly Thr Cys Ser Arg Pro Ile Ser 
            900                 905                 910         


Pro Leu Leu Asp Gln Asn Thr Pro Asp Phe Thr Thr Phe Cys Ser Val 
        915                 920                 925             


Gly Glu Trp Leu Gln Ala Ile Lys Met Glu Arg Tyr Lys Asp Asn Phe 
    930                 935                 940                 


Thr Ala Ala Gly Tyr Asn Ser Leu Glu Ser Val Ala Arg Met Thr Ile 
945                 950                 955                 960 


Glu Asp Val Met Ser Leu Gly Ile Thr Leu Val Gly His Gln Lys Lys 
                965                 970                 975     


Ile Met Ser Ser Ile Gln Thr Met Arg Ala Gln Met Leu His Leu His 
            980                 985                 990         


Gly Thr Gly Ile Gln Val 
        995             


<210>  3046
<211>  984
<212>  PRT
<213>  Homo sapiens

<400>  3046

Met Ala Leu Asp Tyr Leu Leu Leu Leu Leu Leu Ala Ser Ala Val Ala 
1               5                   10                  15      


Ala Met Glu Glu Thr Leu Met Asp Thr Arg Thr Ala Thr Ala Glu Leu 
            20                  25                  30          


Gly Trp Thr Ala Asn Pro Ala Ser Gly Trp Glu Glu Val Ser Gly Tyr 
        35                  40                  45              


Asp Glu Asn Leu Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val Phe 
    50                  55                  60                  


Glu Pro Asn Gln Asn Asn Trp Leu Leu Thr Thr Phe Ile Asn Arg Arg 
65                  70                  75                  80  


Gly Ala His Arg Ile Tyr Thr Glu Met Arg Phe Thr Val Arg Asp Cys 
                85                  90                  95      


Ser Ser Leu Pro Asn Val Pro Gly Ser Cys Lys Glu Thr Phe Asn Leu 
            100                 105                 110         


Tyr Tyr Tyr Glu Thr Asp Ser Val Ile Ala Thr Lys Lys Ser Ala Phe 
        115                 120                 125             


Trp Ser Glu Ala Pro Tyr Leu Lys Val Asp Thr Ile Ala Ala Asp Glu 
    130                 135                 140                 


Ser Phe Ser Gln Val Asp Phe Gly Gly Arg Leu Met Lys Val Asn Thr 
145                 150                 155                 160 


Glu Val Arg Ser Phe Gly Pro Leu Thr Arg Asn Gly Phe Tyr Leu Ala 
                165                 170                 175     


Phe Gln Asp Tyr Gly Ala Cys Met Ser Leu Leu Ser Val Arg Val Phe 
            180                 185                 190         


Phe Lys Lys Cys Pro Ser Ile Val Gln Asn Phe Ala Val Phe Pro Glu 
        195                 200                 205             


Thr Met Thr Gly Ala Glu Ser Thr Ser Leu Val Ile Ala Arg Gly Thr 
    210                 215                 220                 


Cys Ile Pro Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr Cys 
225                 230                 235                 240 


Asn Gly Asp Gly Glu Trp Met Val Pro Ile Gly Arg Cys Thr Cys Lys 
                245                 250                 255     


Pro Gly Tyr Glu Pro Glu Asn Ser Val Ala Cys Lys Ala Cys Pro Ala 
            260                 265                 270         


Gly Thr Phe Lys Ala Ser Gln Glu Ala Glu Gly Cys Ser His Cys Pro 
        275                 280                 285             


Ser Asn Ser Arg Ser Pro Ala Glu Ala Ser Pro Ile Cys Thr Cys Arg 
    290                 295                 300                 


Thr Gly Tyr Tyr Arg Ala Asp Phe Asp Pro Pro Glu Val Ala Cys Thr 
305                 310                 315                 320 


Ser Val Pro Ser Gly Pro Arg Asn Val Ile Ser Ile Val Asn Glu Thr 
                325                 330                 335     


Ser Ile Ile Leu Glu Trp His Pro Pro Arg Glu Thr Gly Gly Arg Asp 
            340                 345                 350         


Asp Val Thr Tyr Asn Ile Ile Cys Lys Lys Cys Arg Ala Asp Arg Arg 
        355                 360                 365             


Ser Cys Ser Arg Cys Asp Asp Asn Val Glu Phe Val Pro Arg Gln Leu 
    370                 375                 380                 


Gly Leu Thr Glu Cys Arg Val Ser Ile Ser Ser Leu Trp Ala His Thr 
385                 390                 395                 400 


Pro Tyr Thr Phe Asp Ile Gln Ala Ile Asn Gly Val Ser Ser Lys Ser 
                405                 410                 415     


Pro Phe Pro Pro Gln His Val Ser Val Asn Ile Thr Thr Asn Gln Ala 
            420                 425                 430         


Ala Pro Ser Thr Val Pro Ile Met His Gln Val Ser Ala Thr Met Arg 
        435                 440                 445             


Ser Ile Thr Leu Ser Trp Pro Gln Pro Glu Gln Pro Asn Gly Ile Ile 
    450                 455                 460                 


Leu Asp Tyr Glu Ile Arg Tyr Tyr Glu Lys Glu His Asn Glu Phe Asn 
465                 470                 475                 480 


Ser Ser Met Ala Arg Ser Gln Thr Asn Thr Ala Arg Ile Asp Gly Leu 
                485                 490                 495     


Arg Pro Gly Met Val Tyr Val Val Gln Val Arg Ala Arg Thr Val Ala 
            500                 505                 510         


Gly Tyr Gly Lys Phe Ser Gly Lys Met Cys Phe Gln Thr Leu Thr Asp 
        515                 520                 525             


Asp Asp Tyr Lys Ser Glu Leu Arg Glu Gln Leu Pro Leu Ile Ala Gly 
    530                 535                 540                 


Ser Ala Ala Ala Gly Val Val Phe Val Val Ser Leu Val Ala Ile Ser 
545                 550                 555                 560 


Ile Val Cys Ser Arg Lys Arg Ala Tyr Ser Lys Glu Ala Val Tyr Ser 
                565                 570                 575     


Asp Lys Leu Gln His Tyr Ser Thr Gly Arg Gly Ser Pro Gly Met Lys 
            580                 585                 590         


Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg 
        595                 600                 605             


Glu Phe Ala Lys Glu Ile Asp Val Ser Phe Val Lys Ile Glu Glu Val 
    610                 615                 620                 


Ile Gly Ala Gly Glu Phe Gly Glu Val Tyr Lys Gly Arg Leu Lys Leu 
625                 630                 635                 640 


Pro Gly Lys Arg Glu Ile Tyr Val Ala Ile Lys Thr Leu Lys Ala Gly 
                645                 650                 655     


Tyr Ser Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser Ile Met 
            660                 665                 670         


Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr 
        675                 680                 685             


Lys Ser Arg Pro Val Met Ile Ile Thr Glu Phe Met Glu Asn Gly Ala 
    690                 695                 700                 


Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr Val Ile Gln 
705                 710                 715                 720 


Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ala 
                725                 730                 735     


Glu Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val 
            740                 745                 750         


Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Tyr 
        755                 760                 765             


Leu Gln Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ser Leu Gly Gly 
    770                 775                 780                 


Lys Ile Pro Val Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys 
785                 790                 795                 800 


Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu 
                805                 810                 815     


Val Met Ser Phe Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp 
            820                 825                 830         


Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro Met Asp 
        835                 840                 845             


Cys Pro Ala Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Asp 
    850                 855                 860                 


Arg Asn Ser Arg Pro Arg Phe Ala Glu Ile Val Asn Thr Leu Asp Lys 
865                 870                 875                 880 


Met Ile Arg Asn Pro Ala Ser Leu Lys Thr Val Ala Thr Ile Thr Ala 
                885                 890                 895     


Val Pro Ser Gln Pro Leu Leu Asp Arg Ser Ile Pro Asp Phe Thr Ala 
            900                 905                 910         


Phe Thr Thr Val Asp Asp Trp Leu Ser Ala Ile Lys Met Val Gln Tyr 
        915                 920                 925             


Arg Asp Ser Phe Leu Thr Ala Gly Phe Thr Ser Leu Gln Leu Val Thr 
    930                 935                 940                 


Gln Met Thr Ser Glu Asp Leu Leu Arg Ile Gly Ile Thr Leu Ala Gly 
945                 950                 955                 960 


His Gln Lys Lys Ile Leu Asn Ser Ile His Ser Met Arg Val Gln Ile 
                965                 970                 975     


Ser Gln Ser Pro Thr Ala Met Ala 
            980                 


<210>  3047
<211>  987
<212>  PRT
<213>  Homo sapiens

<400>  3047

Met Ala Leu Arg Arg Leu Gly Ala Ala Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Ala Ala Val Glu Glu Thr Leu Met Asp Ser Thr Thr Ala Thr Ala Glu 
            20                  25                  30          


Leu Gly Trp Met Val His Pro Pro Ser Gly Trp Glu Glu Val Ser Gly 
        35                  40                  45              


Tyr Asp Glu Asn Met Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val 
    50                  55                  60                  


Phe Glu Ser Ser Gln Asn Asn Trp Leu Arg Thr Lys Phe Ile Arg Arg 
65                  70                  75                  80  


Arg Gly Ala His Arg Ile His Val Glu Met Lys Phe Ser Val Arg Asp 
                85                  90                  95      


Cys Ser Ser Ile Pro Ser Val Pro Gly Ser Cys Lys Glu Thr Phe Asn 
            100                 105                 110         


Leu Tyr Tyr Tyr Glu Ala Asp Phe Asp Ser Ala Thr Lys Thr Phe Pro 
        115                 120                 125             


Asn Trp Met Glu Asn Pro Trp Val Lys Val Asp Thr Ile Ala Ala Asp 
    130                 135                 140                 


Glu Ser Phe Ser Gln Val Asp Leu Gly Gly Arg Val Met Lys Ile Asn 
145                 150                 155                 160 


Thr Glu Val Arg Ser Phe Gly Pro Val Ser Arg Ser Gly Phe Tyr Leu 
                165                 170                 175     


Ala Phe Gln Asp Tyr Gly Gly Cys Met Ser Leu Ile Ala Val Arg Val 
            180                 185                 190         


Phe Tyr Arg Lys Cys Pro Arg Ile Ile Gln Asn Gly Ala Ile Phe Gln 
        195                 200                 205             


Glu Thr Leu Ser Gly Ala Glu Ser Thr Ser Leu Val Ala Ala Arg Gly 
    210                 215                 220                 


Ser Cys Ile Ala Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr 
225                 230                 235                 240 


Cys Asn Gly Asp Gly Glu Trp Leu Val Pro Ile Gly Arg Cys Met Cys 
                245                 250                 255     


Lys Ala Gly Phe Glu Ala Val Glu Asn Gly Thr Val Cys Arg Gly Cys 
            260                 265                 270         


Pro Ser Gly Thr Phe Lys Ala Asn Gln Gly Asp Glu Ala Cys Thr His 
        275                 280                 285             


Cys Pro Ile Asn Ser Arg Thr Thr Ser Glu Gly Ala Thr Asn Cys Val 
    290                 295                 300                 


Cys Arg Asn Gly Tyr Tyr Arg Ala Asp Leu Asp Pro Leu Asp Met Pro 
305                 310                 315                 320 


Cys Thr Thr Ile Pro Ser Ala Pro Gln Ala Val Ile Ser Ser Val Asn 
                325                 330                 335     


Glu Thr Ser Leu Met Leu Glu Trp Thr Pro Pro Arg Asp Ser Gly Gly 
            340                 345                 350         


Arg Glu Asp Leu Val Tyr Asn Ile Ile Cys Lys Ser Cys Gly Ser Gly 
        355                 360                 365             


Arg Gly Ala Cys Thr Arg Cys Gly Asp Asn Val Gln Tyr Ala Pro Arg 
    370                 375                 380                 


Gln Leu Gly Leu Thr Glu Pro Arg Ile Tyr Ile Ser Asp Leu Leu Ala 
385                 390                 395                 400 


His Thr Gln Tyr Thr Phe Glu Ile Gln Ala Val Asn Gly Val Thr Asp 
                405                 410                 415     


Gln Ser Pro Phe Ser Pro Gln Phe Ala Ser Val Asn Ile Thr Thr Asn 
            420                 425                 430         


Gln Ala Ala Pro Ser Ala Val Ser Ile Met His Gln Val Ser Arg Thr 
        435                 440                 445             


Val Asp Ser Ile Thr Leu Ser Trp Ser Gln Pro Asp Gln Pro Asn Gly 
    450                 455                 460                 


Val Ile Leu Asp Tyr Glu Leu Gln Tyr Tyr Glu Lys Glu Leu Ser Glu 
465                 470                 475                 480 


Tyr Asn Ala Thr Ala Ile Lys Ser Pro Thr Asn Thr Val Thr Val Gln 
                485                 490                 495     


Gly Leu Lys Ala Gly Ala Ile Tyr Val Phe Gln Val Arg Ala Arg Thr 
            500                 505                 510         


Val Ala Gly Tyr Gly Arg Tyr Ser Gly Lys Met Tyr Phe Gln Thr Met 
        515                 520                 525             


Thr Glu Ala Glu Tyr Gln Thr Ser Ile Gln Glu Lys Leu Pro Leu Ile 
    530                 535                 540                 


Ile Gly Ser Ser Ala Ala Gly Leu Val Phe Leu Ile Ala Val Val Val 
545                 550                 555                 560 


Ile Ala Ile Val Cys Asn Arg Arg Arg Gly Phe Glu Arg Ala Asp Ser 
                565                 570                 575     


Glu Tyr Thr Asp Lys Leu Gln His Tyr Thr Ser Gly His Met Thr Pro 
            580                 585                 590         


Gly Met Lys Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu 
        595                 600                 605             


Ala Val Arg Glu Phe Ala Lys Glu Ile Asp Ile Ser Cys Val Lys Ile 
    610                 615                 620                 


Glu Gln Val Ile Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly His 
625                 630                 635                 640 


Leu Lys Leu Pro Gly Lys Arg Glu Ile Phe Val Ala Ile Lys Thr Leu 
                645                 650                 655     


Lys Ser Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala 
            660                 665                 670         


Ser Ile Met Gly Gln Phe Asp His Pro Asn Val Ile His Leu Glu Gly 
        675                 680                 685             


Val Val Thr Lys Ser Thr Pro Val Met Ile Ile Thr Glu Phe Met Glu 
    690                 695                 700                 


Asn Gly Ser Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr 
705                 710                 715                 720 


Val Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys 
                725                 730                 735     


Tyr Leu Ala Asp Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn 
            740                 745                 750         


Ile Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu 
        755                 760                 765             


Ser Arg Phe Leu Glu Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ala 
    770                 775                 780                 


Leu Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Gln 
785                 790                 795                 800 


Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val 
                805                 810                 815     


Met Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Thr 
            820                 825                 830         


Asn Gln Asp Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro 
        835                 840                 845             


Pro Met Asp Cys Pro Ser Ala Leu His Gln Leu Met Leu Asp Cys Trp 
    850                 855                 860                 


Gln Lys Asp Arg Asn His Arg Pro Lys Phe Gly Gln Ile Val Asn Thr 
865                 870                 875                 880 


Leu Asp Lys Met Ile Arg Asn Pro Asn Ser Leu Lys Ala Met Ala Pro 
                885                 890                 895     


Leu Ser Ser Gly Ile Asn Leu Pro Leu Leu Asp Arg Thr Ile Pro Asp 
            900                 905                 910         


Tyr Thr Ser Phe Asn Thr Val Asp Glu Trp Leu Glu Ala Ile Lys Met 
        915                 920                 925             


Gly Gln Tyr Lys Glu Ser Phe Ala Asn Ala Gly Phe Thr Ser Phe Asp 
    930                 935                 940                 


Val Val Ser Gln Met Met Met Glu Asp Ile Leu Arg Val Gly Val Thr 
945                 950                 955                 960 


Leu Ala Gly His Gln Lys Lys Ile Leu Asn Ser Ile Gln Val Met Arg 
                965                 970                 975     


Ala Gln Met Asn Gln Ile Gln Ser Val Glu Val 
            980                 985         


<210>  3048
<211>  998
<212>  PRT
<213>  Homo sapiens

<400>  3048

Met Ala Arg Ala Arg Pro Pro Pro Pro Pro Ser Pro Pro Pro Gly Leu 
1               5                   10                  15      


Leu Pro Leu Leu Pro Pro Leu Leu Leu Leu Pro Leu Leu Leu Leu Pro 
            20                  25                  30          


Ala Gly Cys Arg Ala Leu Glu Glu Thr Leu Met Asp Thr Lys Trp Val 
        35                  40                  45              


Thr Ser Glu Leu Ala Trp Thr Ser His Pro Glu Ser Gly Trp Glu Glu 
    50                  55                  60                  


Val Ser Gly Tyr Asp Glu Ala Met Asn Pro Ile Arg Thr Tyr Gln Val 
65                  70                  75                  80  


Cys Asn Val Arg Glu Ser Ser Gln Asn Asn Trp Leu Arg Thr Gly Phe 
                85                  90                  95      


Ile Trp Arg Arg Asp Val Gln Arg Val Tyr Val Glu Leu Lys Phe Thr 
            100                 105                 110         


Val Arg Asp Cys Asn Ser Ile Pro Asn Ile Pro Gly Ser Cys Lys Glu 
        115                 120                 125             


Thr Phe Asn Leu Phe Tyr Tyr Glu Ala Asp Ser Asp Val Ala Ser Ala 
    130                 135                 140                 


Ser Ser Pro Phe Trp Met Glu Asn Pro Tyr Val Lys Val Asp Thr Ile 
145                 150                 155                 160 


Ala Pro Asp Glu Ser Phe Ser Arg Leu Asp Ala Gly Arg Val Asn Thr 
                165                 170                 175     


Lys Val Arg Ser Phe Gly Pro Leu Ser Lys Ala Gly Phe Tyr Leu Ala 
            180                 185                 190         


Phe Gln Asp Gln Gly Ala Cys Met Ser Leu Ile Ser Val Arg Ala Phe 
        195                 200                 205             


Tyr Lys Lys Cys Ala Ser Thr Thr Ala Gly Phe Ala Leu Phe Pro Glu 
    210                 215                 220                 


Thr Leu Thr Gly Ala Glu Pro Thr Ser Leu Val Ile Ala Pro Gly Thr 
225                 230                 235                 240 


Cys Ile Pro Asn Ala Val Glu Val Ser Val Pro Leu Lys Leu Tyr Cys 
                245                 250                 255     


Asn Gly Asp Gly Glu Trp Met Val Pro Val Gly Ala Cys Thr Cys Ala 
            260                 265                 270         


Thr Gly His Glu Pro Ala Ala Lys Glu Ser Gln Cys Arg Pro Cys Pro 
        275                 280                 285             


Pro Gly Ser Tyr Lys Ala Lys Gln Gly Glu Gly Pro Cys Leu Pro Cys 
    290                 295                 300                 


Pro Pro Asn Ser Arg Thr Thr Ser Pro Ala Ala Ser Ile Cys Thr Cys 
305                 310                 315                 320 


His Asn Asn Phe Tyr Arg Ala Asp Ser Asp Ser Ala Asp Ser Ala Cys 
                325                 330                 335     


Thr Thr Val Pro Ser Pro Pro Arg Gly Val Ile Ser Asn Val Asn Glu 
            340                 345                 350         


Thr Ser Leu Ile Leu Glu Trp Ser Glu Pro Arg Asp Leu Gly Gly Arg 
        355                 360                 365             


Asp Asp Leu Leu Tyr Asn Val Ile Cys Lys Lys Cys His Gly Ala Gly 
    370                 375                 380                 


Gly Ala Ser Ala Cys Ser Arg Cys Asp Asp Asn Val Glu Phe Val Pro 
385                 390                 395                 400 


Arg Gln Leu Gly Leu Thr Glu Arg Arg Val His Ile Ser His Leu Leu 
                405                 410                 415     


Ala His Thr Arg Tyr Thr Phe Glu Val Gln Ala Val Asn Gly Val Ser 
            420                 425                 430         


Gly Lys Ser Pro Leu Pro Pro Arg Tyr Ala Ala Val Asn Ile Thr Thr 
        435                 440                 445             


Asn Gln Ala Ala Pro Ser Glu Val Pro Thr Leu Arg Leu His Ser Ser 
    450                 455                 460                 


Ser Gly Ser Ser Leu Thr Leu Ser Trp Ala Pro Pro Glu Arg Pro Asn 
465                 470                 475                 480 


Gly Val Ile Leu Asp Tyr Glu Met Lys Tyr Phe Glu Lys Ser Glu Gly 
                485                 490                 495     


Ile Ala Ser Thr Val Thr Ser Gln Met Asn Ser Val Gln Leu Asp Gly 
            500                 505                 510         


Leu Arg Pro Asp Ala Arg Tyr Val Val Gln Val Arg Ala Arg Thr Val 
        515                 520                 525             


Ala Gly Tyr Gly Gln Tyr Ser Arg Pro Ala Glu Phe Glu Thr Thr Ser 
    530                 535                 540                 


Glu Arg Gly Ser Gly Ala Gln Gln Leu Gln Glu Gln Leu Pro Leu Ile 
545                 550                 555                 560 


Val Gly Ser Ala Thr Ala Gly Leu Val Phe Val Val Ala Val Val Val 
                565                 570                 575     


Ile Ala Ile Val Cys Leu Arg Lys Gln Arg His Gly Ser Asp Ser Glu 
            580                 585                 590         


Tyr Thr Glu Lys Leu Gln Gln Tyr Ile Ala Pro Gly Met Lys Val Tyr 
        595                 600                 605             


Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg Glu Phe 
    610                 615                 620                 


Ala Lys Glu Ile Asp Val Ser Cys Val Lys Ile Glu Glu Val Ile Gly 
625                 630                 635                 640 


Ala Gly Glu Phe Gly Glu Val Cys Arg Gly Arg Leu Lys Gln Pro Gly 
                645                 650                 655     


Arg Arg Glu Val Phe Val Ala Ile Lys Thr Leu Lys Val Gly Tyr Thr 
            660                 665                 670         


Glu Arg Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser Ile Met Gly Gln 
        675                 680                 685             


Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr Lys Ser 
    690                 695                 700                 


Arg Pro Val Met Ile Leu Thr Glu Phe Met Glu Asn Cys Ala Leu Asp 
705                 710                 715                 720 


Ser Phe Leu Arg Leu Asn Asp Gly Gln Phe Thr Val Ile Gln Leu Val 
                725                 730                 735     


Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ser Glu Met 
            740                 745                 750         


Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser 
        755                 760                 765             


Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Phe Leu Glu 
    770                 775                 780                 


Asp Asp Pro Ser Asp Pro Thr Tyr Thr Ser Ser Leu Gly Gly Lys Ile 
785                 790                 795                 800 


Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys Phe Thr 
                805                 810                 815     


Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu Val Met 
            820                 825                 830         


Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp Val Ile 
        835                 840                 845             


Asn Ala Val Glu Gln Asp Tyr Arg Leu Pro Pro Pro Met Asp Cys Pro 
    850                 855                 860                 


Thr Ala Leu His Gln Leu Met Leu Asp Cys Trp Val Arg Asp Arg Asn 
865                 870                 875                 880 


Leu Arg Pro Lys Phe Ser Gln Ile Val Asn Thr Leu Asp Lys Leu Ile 
                885                 890                 895     


Arg Asn Ala Ala Ser Leu Lys Val Ile Ala Ser Ala Gln Ser Gly Met 
            900                 905                 910         


Ser Gln Pro Leu Leu Asp Arg Thr Val Pro Asp Tyr Thr Thr Phe Thr 
        915                 920                 925             


Thr Val Gly Asp Trp Leu Asp Ala Ile Lys Met Gly Arg Tyr Lys Glu 
    930                 935                 940                 


Ser Phe Val Ser Ala Gly Phe Ala Ser Phe Asp Leu Val Ala Gln Met 
945                 950                 955                 960 


Thr Ala Glu Asp Leu Leu Arg Ile Gly Val Thr Leu Ala Gly His Gln 
                965                 970                 975     


Lys Lys Ile Leu Ser Ser Ile Gln Asp Met Arg Leu Gln Met Asn Gln 
            980                 985                 990         


Thr Leu Pro Val Gln Val 
        995             


<210>  3049
<211>  987
<212>  PRT
<213>  Homo sapiens

<400>  3049

Met Glu Leu Arg Val Leu Leu Cys Trp Ala Ser Leu Ala Ala Ala Leu 
1               5                   10                  15      


Glu Glu Thr Leu Leu Asn Thr Lys Leu Glu Thr Ala Asp Leu Lys Trp 
            20                  25                  30          


Val Thr Phe Pro Gln Val Asp Gly Gln Trp Glu Glu Leu Ser Gly Leu 
        35                  40                  45              


Asp Glu Glu Gln His Ser Val Arg Thr Tyr Glu Val Cys Asp Val Gln 
    50                  55                  60                  


Arg Ala Pro Gly Gln Ala His Trp Leu Arg Thr Gly Trp Val Pro Arg 
65                  70                  75                  80  


Arg Gly Ala Val His Val Tyr Ala Thr Leu Arg Phe Thr Met Leu Glu 
                85                  90                  95      


Cys Leu Ser Leu Pro Arg Ala Gly Arg Ser Cys Lys Glu Thr Phe Thr 
            100                 105                 110         


Val Phe Tyr Tyr Glu Ser Asp Ala Asp Thr Ala Thr Ala Leu Thr Pro 
        115                 120                 125             


Ala Trp Met Glu Asn Pro Tyr Ile Lys Val Asp Thr Val Ala Ala Glu 
    130                 135                 140                 


His Leu Thr Arg Lys Arg Pro Gly Ala Glu Ala Thr Gly Lys Val Asn 
145                 150                 155                 160 


Val Lys Thr Leu Arg Leu Gly Pro Leu Ser Lys Ala Gly Phe Tyr Leu 
                165                 170                 175     


Ala Phe Gln Asp Gln Gly Ala Cys Met Ala Leu Leu Ser Leu His Leu 
            180                 185                 190         


Phe Tyr Lys Lys Cys Ala Gln Leu Thr Val Asn Leu Thr Arg Phe Pro 
        195                 200                 205             


Glu Thr Val Pro Arg Glu Leu Val Val Pro Val Ala Gly Ser Cys Val 
    210                 215                 220                 


Val Asp Ala Val Pro Ala Pro Gly Pro Ser Pro Ser Leu Tyr Cys Arg 
225                 230                 235                 240 


Glu Asp Gly Gln Trp Ala Glu Gln Pro Val Thr Gly Cys Ser Cys Ala 
                245                 250                 255     


Pro Gly Phe Glu Ala Ala Glu Gly Asn Thr Lys Cys Arg Ala Cys Ala 
            260                 265                 270         


Gln Gly Thr Phe Lys Pro Leu Ser Gly Glu Gly Ser Cys Gln Pro Cys 
        275                 280                 285             


Pro Ala Asn Ser His Ser Asn Thr Ile Gly Ser Ala Val Cys Gln Cys 
    290                 295                 300                 


Arg Val Gly Tyr Phe Arg Ala Arg Thr Asp Pro Arg Gly Ala Pro Cys 
305                 310                 315                 320 


Thr Thr Pro Pro Ser Ala Pro Arg Ser Val Val Ser Arg Leu Asn Gly 
                325                 330                 335     


Ser Ser Leu His Leu Glu Trp Ser Ala Pro Leu Glu Ser Gly Gly Arg 
            340                 345                 350         


Glu Asp Leu Thr Tyr Ala Leu Arg Cys Arg Glu Cys Arg Pro Gly Gly 
        355                 360                 365             


Ser Cys Ala Pro Cys Gly Gly Asp Leu Thr Phe Asp Pro Gly Pro Arg 
    370                 375                 380                 


Asp Leu Val Glu Pro Trp Val Val Val Arg Gly Leu Arg Pro Asp Phe 
385                 390                 395                 400 


Thr Tyr Thr Phe Glu Val Thr Ala Leu Asn Gly Val Ser Ser Leu Ala 
                405                 410                 415     


Thr Gly Pro Val Pro Phe Glu Pro Val Asn Val Thr Thr Asp Arg Glu 
            420                 425                 430         


Val Pro Pro Ala Val Ser Asp Ile Arg Val Thr Arg Ser Ser Pro Ser 
        435                 440                 445             


Ser Leu Ser Leu Ala Trp Ala Val Pro Arg Ala Pro Ser Gly Ala Val 
    450                 455                 460                 


Leu Asp Tyr Glu Val Lys Tyr His Glu Lys Gly Ala Glu Gly Pro Ser 
465                 470                 475                 480 


Ser Val Arg Phe Leu Lys Thr Ser Glu Asn Arg Ala Glu Leu Arg Gly 
                485                 490                 495     


Leu Lys Arg Gly Ala Ser Tyr Leu Val Gln Val Arg Ala Arg Ser Glu 
            500                 505                 510         


Ala Gly Tyr Gly Pro Phe Gly Gln Glu His His Ser Gln Thr Gln Leu 
        515                 520                 525             


Asp Glu Ser Glu Gly Trp Arg Glu Gln Leu Ala Leu Ile Ala Gly Thr 
    530                 535                 540                 


Ala Val Val Gly Val Val Leu Val Leu Val Val Ile Val Val Ala Val 
545                 550                 555                 560 


Leu Cys Leu Arg Lys Gln Ser Asn Gly Arg Glu Ala Glu Tyr Ser Asp 
                565                 570                 575     


Lys His Gly Gln Tyr Leu Ile Gly His Gly Thr Lys Val Tyr Ile Asp 
            580                 585                 590         


Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg Glu Phe Ala Lys 
        595                 600                 605             


Glu Ile Asp Val Ser Tyr Val Lys Ile Glu Glu Val Ile Gly Ala Gly 
    610                 615                 620                 


Glu Phe Gly Glu Val Cys Arg Gly Arg Leu Lys Ala Pro Gly Lys Lys 
625                 630                 635                 640 


Glu Ser Cys Val Ala Ile Lys Thr Leu Lys Gly Gly Tyr Thr Glu Arg 
                645                 650                 655     


Gln Arg Arg Glu Phe Leu Ser Glu Ala Ser Ile Met Gly Gln Phe Glu 
            660                 665                 670         


His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr Asn Ser Met Pro 
        675                 680                 685             


Val Met Ile Leu Thr Glu Phe Met Glu Asn Gly Ala Leu Asp Ser Phe 
    690                 695                 700                 


Leu Arg Leu Asn Asp Gly Gln Phe Thr Val Ile Gln Leu Val Gly Met 
705                 710                 715                 720 


Leu Arg Gly Ile Ala Ser Gly Met Arg Tyr Leu Ala Glu Met Ser Tyr 
                725                 730                 735     


Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn Leu 
            740                 745                 750         


Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Phe Leu Glu Glu Asn 
        755                 760                 765             


Ser Ser Asp Pro Thr Tyr Thr Ser Ser Leu Gly Gly Lys Ile Pro Ile 
    770                 775                 780                 


Arg Trp Thr Ala Pro Glu Ala Ile Ala Phe Arg Lys Phe Thr Ser Ala 
785                 790                 795                 800 


Ser Asp Ala Trp Ser Tyr Gly Ile Val Met Trp Glu Val Met Ser Phe 
                805                 810                 815     


Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp Val Ile Asn Ala 
            820                 825                 830         


Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro Pro Asp Cys Pro Thr Ser 
        835                 840                 845             


Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Asp Arg Asn Ala Arg 
    850                 855                 860                 


Pro Arg Phe Pro Gln Val Val Ser Ala Leu Asp Lys Met Ile Arg Asn 
865                 870                 875                 880 


Pro Ala Ser Leu Lys Ile Val Ala Arg Glu Asn Gly Gly Ala Ser His 
                885                 890                 895     


Pro Leu Leu Asp Gln Arg Gln Pro His Tyr Ser Ala Phe Gly Ser Val 
            900                 905                 910         


Gly Glu Trp Leu Arg Ala Ile Lys Met Gly Arg Tyr Glu Glu Ser Phe 
        915                 920                 925             


Ala Ala Ala Gly Phe Gly Ser Phe Glu Leu Val Ser Gln Ile Ser Ala 
    930                 935                 940                 


Glu Asp Leu Leu Arg Ile Gly Val Thr Leu Ala Gly His Gln Lys Lys 
945                 950                 955                 960 


Ile Leu Ala Ser Val Gln His Met Lys Ser Gln Ala Lys Pro Gly Thr 
                965                 970                 975     


Pro Gly Gly Thr Gly Gly Pro Ala Pro Gln Tyr 
            980                 985         


<210>  3050
<211>  1022
<212>  PRT
<213>  Homo sapiens

<400>  3050

Met Ala Thr Glu Gly Ala Ala Gln Leu Gly Asn Arg Val Ala Gly Met 
1               5                   10                  15      


Val Cys Ser Leu Trp Val Leu Leu Leu Val Ser Ser Val Leu Ala Leu 
            20                  25                  30          


Glu Glu Val Leu Leu Asp Thr Thr Gly Glu Thr Ser Glu Ile Gly Trp 
        35                  40                  45              


Leu Thr Tyr Pro Pro Gly Gly Trp Asp Glu Val Ser Val Leu Asp Asp 
    50                  55                  60                  


Gln Arg Arg Leu Thr Arg Thr Phe Glu Ala Cys His Val Ala Gly Ala 
65                  70                  75                  80  


Pro Pro Gly Thr Gly Gln Asp Asn Trp Leu Gln Thr His Phe Val Glu 
                85                  90                  95      


Arg Arg Gly Ala Gln Arg Ala His Ile Arg Leu His Phe Ser Val Arg 
            100                 105                 110         


Ala Cys Ser Ser Leu Gly Val Ser Gly Gly Thr Cys Arg Glu Thr Phe 
        115                 120                 125             


Thr Leu Tyr Tyr Arg Gln Ala Glu Glu Pro Asp Ser Pro Asp Ser Val 
    130                 135                 140                 


Ser Ser Trp His Leu Lys Arg Trp Thr Lys Val Asp Thr Ile Ala Ala 
145                 150                 155                 160 


Asp Glu Ser Phe Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
                165                 170                 175     


Ser Ala Ala Trp Ala Val Gly Pro His Gly Ala Gly Gln Arg Ala Gly 
            180                 185                 190         


Leu Gln Leu Asn Val Lys Glu Arg Ser Phe Gly Pro Leu Thr Gln Arg 
        195                 200                 205             


Gly Phe Tyr Val Ala Phe Gln Asp Thr Gly Ala Cys Leu Ala Leu Val 
    210                 215                 220                 


Ala Val Arg Leu Phe Ser Tyr Thr Cys Pro Ala Val Leu Arg Ser Phe 
225                 230                 235                 240 


Ala Ser Phe Pro Glu Thr Gln Ala Ser Gly Ala Gly Gly Ala Ser Leu 
                245                 250                 255     


Val Ala Ala Val Gly Thr Cys Val Ala His Ala Glu Pro Glu Glu Asp 
            260                 265                 270         


Gly Val Gly Gly Gln Ala Gly Gly Ser Pro Pro Arg Leu His Cys Asn 
        275                 280                 285             


Gly Glu Gly Lys Trp Met Val Ala Val Gly Gly Cys Arg Cys Gln Pro 
    290                 295                 300                 


Gly Tyr Gln Pro Ala Arg Gly Asp Lys Ala Cys Gln Ala Cys Pro Arg 
305                 310                 315                 320 


Gly Leu Tyr Lys Ala Ser Ala Gly Asn Ala Pro Cys Ser Pro Cys Pro 
                325                 330                 335     


Ala Arg Ser His Ala Pro Asn Pro Ala Ala Pro Val Cys Pro Cys Leu 
            340                 345                 350         


Glu Gly Phe Tyr Arg Ala Ser Ser Asp Pro Pro Glu Ala Pro Cys Thr 
        355                 360                 365             


Gly Pro Pro Ser Ala Pro Gln Glu Leu Trp Phe Glu Val Gln Gly Ser 
    370                 375                 380                 


Ala Leu Met Leu His Trp Arg Leu Pro Arg Glu Leu Gly Gly Arg Gly 
385                 390                 395                 400 


Asp Leu Leu Phe Asn Val Val Cys Lys Glu Cys Glu Gly Arg Gln Glu 
                405                 410                 415     


Pro Ala Ser Gly Gly Gly Gly Thr Cys His Arg Cys Arg Asp Glu Val 
            420                 425                 430         


His Phe Asp Pro Arg Gln Arg Gly Leu Thr Glu Ser Arg Val Leu Val 
        435                 440                 445             


Gly Gly Leu Arg Ala His Val Pro Tyr Ile Leu Glu Val Gln Ala Val 
    450                 455                 460                 


Asn Gly Val Ser Glu Leu Ser Pro Asp Pro Pro Gln Ala Ala Ala Ile 
465                 470                 475                 480 


Asn Val Ser Thr Ser His Glu Val Pro Ser Ala Val Pro Val Val His 
                485                 490                 495     


Gln Val Ser Arg Ala Ser Asn Ser Ile Thr Val Ser Trp Pro Gln Pro 
            500                 505                 510         


Asp Gln Thr Asn Gly Asn Ile Leu Asp Tyr Gln Leu Arg Tyr Tyr Asp 
        515                 520                 525             


Gln Ala Glu Asp Glu Ser His Ser Phe Thr Leu Thr Ser Glu Thr Asn 
    530                 535                 540                 


Thr Ala Thr Val Thr Gln Leu Ser Pro Gly His Ile Tyr Gly Phe Gln 
545                 550                 555                 560 


Val Arg Ala Arg Thr Ala Ala Gly His Gly Pro Tyr Gly Gly Lys Val 
                565                 570                 575     


Tyr Phe Gln Thr Leu Pro Gln Gly Glu Leu Ser Ser Gln Leu Pro Glu 
            580                 585                 590         


Arg Leu Ser Leu Val Ile Gly Ser Ile Leu Gly Ala Leu Ala Phe Leu 
        595                 600                 605             


Leu Leu Ala Ala Ile Thr Val Leu Ala Val Val Phe Gln Arg Lys Arg 
    610                 615                 620                 


Arg Gly Thr Gly Tyr Thr Glu Gln Leu Gln Gln Tyr Ser Ser Pro Gly 
625                 630                 635                 640 


Leu Gly Val Lys Tyr Tyr Ile Asp Pro Ser Thr Tyr Glu Asp Pro Cys 
                645                 650                 655     


Gln Ala Ile Arg Glu Leu Ala Arg Glu Val Asp Pro Ala Tyr Ile Lys 
            660                 665                 670         


Ile Glu Glu Val Ile Gly Thr Gly Ser Phe Gly Glu Val Arg Gln Gly 
        675                 680                 685             


Arg Leu Gln Pro Arg Gly Arg Arg Glu Gln Thr Val Ala Ile Gln Ala 
    690                 695                 700                 


Leu Trp Ala Gly Gly Ala Glu Ser Leu Gln Met Thr Phe Leu Gly Arg 
705                 710                 715                 720 


Ala Ala Val Leu Gly Gln Phe Gln His Pro Asn Ile Leu Arg Leu Glu 
                725                 730                 735     


Gly Val Val Thr Lys Ser Arg Pro Leu Met Val Leu Thr Glu Phe Met 
            740                 745                 750         


Glu Leu Gly Pro Leu Asp Ser Phe Leu Arg Gln Arg Glu Gly Gln Phe 
        755                 760                 765             


Ser Ser Leu Gln Leu Val Ala Met Gln Arg Gly Val Ala Ala Ala Met 
    770                 775                 780                 


Gln Tyr Leu Ser Ser Phe Ala Phe Val His Arg Ser Leu Ser Ala His 
785                 790                 795                 800 


Ser Val Leu Val Asn Ser His Leu Val Cys Lys Val Ala Arg Leu Gly 
                805                 810                 815     


His Ser Pro Gln Gly Pro Ser Cys Leu Leu Arg Trp Ala Ala Pro Glu 
            820                 825                 830         


Val Ile Ala His Gly Lys His Thr Thr Ser Ser Asp Val Trp Ser Phe 
        835                 840                 845             


Gly Ile Leu Met Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp 
    850                 855                 860                 


Asp Met Ser Glu Gln Glu Val Leu Asn Ala Ile Glu Gln Glu Phe Arg 
865                 870                 875                 880 


Leu Pro Pro Pro Pro Gly Cys Pro Pro Gly Leu His Leu Leu Met Leu 
                885                 890                 895     


Asp Thr Trp Gln Lys Asp Arg Ala Arg Arg Pro His Phe Asp Gln Leu 
            900                 905                 910         


Val Ala Ala Phe Asp Lys Met Ile Arg Lys Pro Asp Thr Leu Gln Ala 
        915                 920                 925             


Gly Gly Asp Pro Gly Glu Arg Pro Ser Gln Ala Leu Leu Thr Pro Val 
    930                 935                 940                 


Ala Leu Asp Phe Pro Cys Leu Asp Ser Pro Gln Ala Trp Leu Ser Ala 
945                 950                 955                 960 


Ile Gly Leu Glu Cys Tyr Gln Asp Asn Phe Ser Lys Phe Gly Leu Cys 
                965                 970                 975     


Thr Phe Ser Asp Val Ala Gln Leu Ser Leu Glu Asp Leu Pro Ala Leu 
            980                 985                 990         


Gly Ile Thr Leu Ala Gly His Gln  Lys Lys Leu Leu His  His Ile Gln 
        995                 1000                 1005             


Leu Leu  Gln Gln His Leu Arg  Gln Gln Gly Ser Val  Glu Val 
    1010                 1015                 1020         


<210>  3051
<211>  1255
<212>  PRT
<213>  Homo sapiens

<400>  3051

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg 
        675                 680                 685             


Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly 
    690                 695                 700                 


Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu 
705                 710                 715                 720 


Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 
                725                 730                 735     


Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 
            740                 745                 750         


Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 
        755                 760                 765             


Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 
    770                 775                 780                 


Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu 
785                 790                 795                 800 


Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg 
                805                 810                 815     


Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly 
            820                 825                 830         


Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala 
        835                 840                 845             


Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 
    850                 855                 860                 


Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 
865                 870                 875                 880 


Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 
                885                 890                 895     


Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 
            900                 905                 910         


Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 
        915                 920                 925             


Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 
    930                 935                 940                 


Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met 
945                 950                 955                 960 


Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe 
                965                 970                 975     


Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu 
            980                 985                 990         


Asp Leu Gly Pro Ala Ser Pro Leu  Asp Ser Thr Phe Tyr  Arg Ser Leu 
        995                 1000                 1005             


Leu Glu  Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 
    1010                 1015                 1020             


Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
    1025                 1030                 1035             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1040                 1045                 1050             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1055                 1060                 1065             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1070                 1075                 1080             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1085                 1090                 1095             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1100                 1105                 1110             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1115                 1120                 1125             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1130                 1135                 1140             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1145                 1150                 1155             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1160                 1165                 1170             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1175                 1180                 1185             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1190                 1195                 1200             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1205                 1210                 1215             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1220                 1225                 1230             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1235                 1240                 1245             


Leu Gly  Leu Asp Val Pro Val  
    1250                 1255 


<210>  3052
<211>  617
<212>  PRT
<213>  Homo sapiens

<400>  3052

Met Leu Val Pro Leu Ala Lys Leu Ser Cys Leu Ala Tyr Gln Cys Phe 
1               5                   10                  15      


His Ala Leu Lys Ile Lys Lys Asn Tyr Leu Pro Leu Cys Ala Thr Arg 
            20                  25                  30          


Trp Ser Ser Thr Ser Thr Val Pro Arg Ile Thr Thr His Tyr Thr Ile 
        35                  40                  45              


Tyr Pro Arg Asp Lys Asp Lys Arg Trp Glu Gly Val Asn Met Glu Arg 
    50                  55                  60                  


Phe Ala Glu Glu Ala Asp Val Val Ile Val Gly Ala Gly Pro Ala Gly 
65                  70                  75                  80  


Leu Ser Ala Ala Val Arg Leu Lys Gln Leu Ala Val Ala His Glu Lys 
                85                  90                  95      


Asp Ile Arg Val Cys Leu Val Glu Lys Ala Ala Gln Ile Gly Ala His 
            100                 105                 110         


Thr Leu Ser Gly Ala Cys Leu Asp Pro Gly Ala Phe Lys Glu Leu Phe 
        115                 120                 125             


Pro Asp Trp Lys Glu Lys Gly Ala Pro Leu Asn Thr Pro Val Thr Glu 
    130                 135                 140                 


Asp Arg Phe Gly Ile Leu Thr Glu Lys Tyr Arg Ile Pro Val Pro Ile 
145                 150                 155                 160 


Leu Pro Gly Leu Pro Met Asn Asn His Gly Asn Tyr Ile Val Arg Leu 
                165                 170                 175     


Gly His Leu Val Ser Trp Met Gly Glu Gln Ala Glu Ala Leu Gly Val 
            180                 185                 190         


Glu Val Tyr Pro Gly Tyr Ala Ala Ala Glu Val Leu Phe His Asp Asp 
        195                 200                 205             


Gly Ser Val Lys Gly Ile Ala Thr Asn Asp Val Gly Ile Gln Lys Asp 
    210                 215                 220                 


Gly Ala Pro Lys Ala Thr Phe Glu Arg Gly Leu Glu Leu His Ala Lys 
225                 230                 235                 240 


Val Thr Ile Phe Ala Glu Gly Cys His Gly His Leu Ala Lys Gln Leu 
                245                 250                 255     


Tyr Lys Lys Phe Asp Leu Arg Ala Asn Cys Glu Pro Gln Thr Tyr Gly 
            260                 265                 270         


Ile Gly Leu Lys Glu Leu Trp Val Ile Asp Glu Lys Asn Trp Lys Pro 
        275                 280                 285             


Gly Arg Val Asp His Thr Val Gly Trp Pro Leu Asp Arg His Thr Tyr 
    290                 295                 300                 


Gly Gly Ser Phe Leu Tyr His Leu Asn Glu Gly Glu Pro Leu Val Ala 
305                 310                 315                 320 


Leu Gly Leu Val Val Gly Leu Asp Tyr Gln Asn Pro Tyr Leu Ser Pro 
                325                 330                 335     


Phe Arg Glu Phe Gln Arg Trp Lys His His Pro Ser Ile Arg Pro Thr 
            340                 345                 350         


Leu Glu Gly Gly Lys Arg Ile Ala Tyr Gly Ala Arg Ala Leu Asn Glu 
        355                 360                 365             


Gly Gly Phe Gln Ser Ile Pro Lys Leu Thr Phe Pro Gly Gly Leu Leu 
    370                 375                 380                 


Ile Gly Cys Ser Pro Gly Phe Met Asn Val Pro Lys Ile Lys Gly Thr 
385                 390                 395                 400 


His Thr Ala Met Lys Ser Gly Ile Leu Ala Ala Glu Ser Ile Phe Asn 
                405                 410                 415     


Gln Leu Thr Ser Glu Asn Leu Gln Ser Lys Thr Ile Gly Leu His Val 
            420                 425                 430         


Thr Glu Tyr Glu Asp Asn Leu Lys Asn Ser Trp Val Trp Lys Glu Leu 
        435                 440                 445             


Tyr Ser Val Arg Asn Ile Arg Pro Ser Cys His Gly Val Leu Gly Val 
    450                 455                 460                 


Tyr Gly Gly Met Ile Tyr Thr Gly Ile Phe Tyr Trp Ile Leu Arg Gly 
465                 470                 475                 480 


Met Glu Pro Trp Thr Leu Lys His Lys Gly Ser Asp Phe Glu Arg Leu 
                485                 490                 495     


Lys Pro Ala Lys Asp Cys Thr Pro Ile Glu Tyr Pro Lys Pro Asp Gly 
            500                 505                 510         


Gln Ile Ser Phe Asp Leu Leu Ser Ser Val Ala Leu Ser Gly Thr Asn 
        515                 520                 525             


His Glu His Asp Gln Pro Ala His Leu Thr Leu Arg Asp Asp Ser Ile 
    530                 535                 540                 


Pro Val Asn Arg Asn Leu Ser Ile Tyr Asp Gly Pro Glu Gln Arg Phe 
545                 550                 555                 560 


Cys Pro Ala Gly Val Tyr Glu Phe Val Pro Val Glu Gln Gly Asp Gly 
                565                 570                 575     


Phe Arg Leu Gln Ile Asn Ala Gln Asn Cys Val His Cys Lys Thr Cys 
            580                 585                 590         


Asp Ile Lys Asp Pro Ser Gln Asn Ile Asn Trp Val Val Pro Glu Gly 
        595                 600                 605             


Gly Gly Gly Pro Ala Tyr Asn Gly Met 
    610                 615         


<210>  3053
<211>  676
<212>  PRT
<213>  Homo sapiens

<400>  3053

Met Gln Ser Trp Arg Arg Arg Lys Ser Leu Trp Leu Ala Leu Ser Ala 
1               5                   10                  15      


Ser Trp Leu Leu Leu Val Leu Leu Gly Gly Phe Ser Leu Leu Arg Leu 
            20                  25                  30          


Ala Leu Pro Pro Arg Pro Arg Pro Gly Ala Ser Gln Gly Trp Pro Arg 
        35                  40                  45              


Trp Leu Asp Ala Glu Leu Leu Gln Ser Phe Ser Gln Pro Gly Glu Leu 
    50                  55                  60                  


Pro Glu Asp Ala Val Ser Pro Pro Gln Ala Pro His Gly Gly Ser Cys 
65                  70                  75                  80  


Asn Trp Glu Ser Cys Phe Asp Thr Ser Lys Cys Arg Gly Asp Gly Leu 
                85                  90                  95      


Lys Val Phe Val Tyr Pro Ala Val Gly Thr Ile Ser Glu Thr His Arg 
            100                 105                 110         


Arg Ile Leu Ala Ser Ile Glu Gly Ser Arg Phe Tyr Thr Phe Ser Pro 
        115                 120                 125             


Ala Gly Ala Cys Leu Leu Leu Leu Leu Ser Leu Asp Ala Gln Thr Gly 
    130                 135                 140                 


Glu Cys Ser Ser Met Pro Leu Gln Trp Asn Arg Gly Arg Asn His Leu 
145                 150                 155                 160 


Val Leu Arg Leu His Pro Ala Pro Cys Pro Arg Thr Phe Gln Leu Gly 
                165                 170                 175     


Gln Ala Met Val Ala Glu Ala Ser Pro Thr Val Asp Ser Phe Arg Pro 
            180                 185                 190         


Gly Phe Asp Val Ala Leu Pro Phe Leu Pro Glu Ala His Pro Leu Arg 
        195                 200                 205             


Gly Gly Ala Pro Gly Gln Leu Arg Gln His Ser Pro Gln Pro Gly Val 
    210                 215                 220                 


Ala Leu Leu Ala Leu Glu Glu Glu Arg Gly Gly Trp Arg Thr Ala Asp 
225                 230                 235                 240 


Thr Gly Ser Ser Ala Cys Pro Trp Asp Gly Arg Cys Glu Gln Asp Pro 
                245                 250                 255     


Gly Pro Gly Gln Thr Gln Arg Gln Glu Thr Leu Pro Asn Ala Thr Phe 
            260                 265                 270         


Cys Leu Ile Ser Gly His Arg Pro Glu Ala Ala Ser Arg Phe Leu Gln 
        275                 280                 285             


Ala Leu Gln Ala Gly Cys Ile Pro Val Leu Leu Ser Pro Arg Trp Glu 
    290                 295                 300                 


Leu Pro Phe Ser Glu Val Ile Asp Trp Thr Lys Ala Ala Ile Val Ala 
305                 310                 315                 320 


Asp Glu Arg Leu Pro Leu Gln Val Leu Ala Ala Leu Gln Glu Met Ser 
                325                 330                 335     


Pro Ala Arg Val Leu Ala Leu Arg Gln Gln Thr Gln Phe Leu Trp Asp 
            340                 345                 350         


Ala Tyr Phe Ser Ser Val Glu Lys Val Ile His Thr Thr Leu Glu Val 
        355                 360                 365             


Ile Gln Asp Arg Ile Phe Gly Thr Ser Ala His Pro Ser Leu Leu Trp 
    370                 375                 380                 


Asn Ser Pro Pro Gly Ala Leu Leu Ala Leu Ser Thr Phe Ser Thr Ser 
385                 390                 395                 400 


Pro Gln Asp Phe Pro Phe Tyr Tyr Leu Gln Gln Gly Ser Arg Pro Glu 
                405                 410                 415     


Gly Arg Phe Ser Ala Leu Ile Trp Val Gly Pro Pro Gly Gln Pro Pro 
            420                 425                 430         


Leu Lys Leu Ile Gln Ala Val Ala Gly Ser Gln His Cys Ala Gln Ile 
        435                 440                 445             


Leu Val Leu Trp Ser Asn Glu Arg Pro Leu Pro Ser Arg Trp Pro Glu 
    450                 455                 460                 


Thr Ala Val Pro Leu Thr Val Ile Asp Gly His Arg Lys Val Ser Asp 
465                 470                 475                 480 


Arg Phe Tyr Pro Tyr Ser Thr Ile Arg Thr Asp Ala Ile Leu Ser Leu 
                485                 490                 495     


Asp Ala Arg Ser Ser Leu Ser Thr Ser Glu Val Asp Phe Ala Phe Leu 
            500                 505                 510         


Val Trp Gln Ser Phe Pro Glu Arg Met Val Gly Phe Leu Thr Ser Ser 
        515                 520                 525             


His Phe Trp Asp Glu Ala His Gly Gly Trp Gly Tyr Thr Ala Glu Arg 
    530                 535                 540                 


Thr Asn Glu Phe Ser Met Val Leu Thr Thr Ala Ala Phe Tyr His Arg 
545                 550                 555                 560 


Tyr Tyr His Thr Leu Phe Thr His Ser Leu Pro Lys Ala Leu Arg Thr 
                565                 570                 575     


Leu Ala Asp Glu Ala Pro Thr Cys Val Asp Val Leu Met Asn Phe Ile 
            580                 585                 590         


Val Ala Ala Val Thr Lys Leu Pro Pro Ile Lys Val Pro Tyr Gly Lys 
        595                 600                 605             


Gln Arg Gln Glu Ala Ala Pro Leu Ala Pro Gly Gly Pro Gly Pro Arg 
    610                 615                 620                 


Pro Lys Pro Pro Ala Pro Ala Pro Asp Cys Ile Asn Gln Ile Ala Ala 
625                 630                 635                 640 


Ala Phe Gly His Met Pro Leu Leu Ser Ser Arg Leu Arg Leu Asp Pro 
                645                 650                 655     


Val Leu Phe Lys Asp Pro Val Ser Val Gln Arg Lys Lys Tyr Arg Ser 
            660                 665                 670         


Leu Glu Lys Pro 
        675     


<210>  3054
<211>  720
<212>  PRT
<213>  Homo sapiens

<400>  3054

Met Asn Asn His Val Ser Ser Lys Pro Ser Thr Met Lys Leu Lys His 
1               5                   10                  15      


Thr Ile Asn Pro Ile Leu Leu Tyr Phe Ile His Phe Leu Ile Ser Leu 
            20                  25                  30          


Tyr Thr Ile Leu Thr Tyr Ile Pro Phe Tyr Phe Phe Ser Glu Ser Arg 
        35                  40                  45              


Gln Glu Lys Ser Asn Arg Ile Lys Ala Lys Pro Val Asn Ser Lys Pro 
    50                  55                  60                  


Asp Ser Ala Tyr Arg Ser Val Asn Ser Leu Asp Gly Leu Ala Ser Val 
65                  70                  75                  80  


Leu Tyr Pro Gly Cys Asp Thr Leu Asp Lys Val Phe Thr Tyr Ala Lys 
                85                  90                  95      


Asn Lys Phe Lys Asn Lys Arg Leu Leu Gly Thr Arg Glu Val Leu Asn 
            100                 105                 110         


Glu Glu Asp Glu Val Gln Pro Asn Gly Lys Ile Phe Lys Lys Val Ile 
        115                 120                 125             


Leu Gly Gln Tyr Asn Trp Leu Ser Tyr Glu Asp Val Phe Val Arg Ala 
    130                 135                 140                 


Phe Asn Phe Gly Asn Gly Leu Gln Met Leu Gly Gln Lys Pro Lys Thr 
145                 150                 155                 160 


Asn Ile Ala Ile Phe Cys Glu Thr Arg Ala Glu Trp Met Ile Ala Ala 
                165                 170                 175     


Gln Ala Cys Phe Met Tyr Asn Phe Gln Leu Val Thr Leu Tyr Ala Thr 
            180                 185                 190         


Leu Gly Gly Pro Ala Ile Val His Ala Leu Asn Glu Thr Glu Val Thr 
        195                 200                 205             


Asn Ile Ile Thr Ser Lys Glu Leu Leu Gln Thr Lys Leu Lys Asp Ile 
    210                 215                 220                 


Val Ser Leu Val Pro Arg Leu Arg His Ile Ile Thr Val Asp Gly Lys 
225                 230                 235                 240 


Pro Pro Thr Trp Ser Glu Phe Pro Lys Gly Ile Ile Val His Thr Met 
                245                 250                 255     


Ala Ala Val Glu Ala Leu Gly Ala Lys Ala Ser Met Glu Asn Gln Pro 
            260                 265                 270         


His Ser Lys Pro Leu Pro Ser Asp Ile Ala Val Ile Met Tyr Thr Ser 
        275                 280                 285             


Gly Ser Thr Gly Leu Pro Lys Gly Val Met Ile Ser His Ser Asn Ile 
    290                 295                 300                 


Ile Ala Gly Ile Thr Gly Met Ala Glu Arg Ile Pro Glu Leu Gly Glu 
305                 310                 315                 320 


Glu Asp Val Tyr Ile Gly Tyr Leu Pro Leu Ala His Val Leu Glu Leu 
                325                 330                 335     


Ser Ala Glu Leu Val Cys Leu Ser His Gly Cys Arg Ile Gly Tyr Ser 
            340                 345                 350         


Ser Pro Gln Thr Leu Ala Asp Gln Ser Ser Lys Ile Lys Lys Gly Ser 
        355                 360                 365             


Lys Gly Asp Thr Ser Met Leu Lys Pro Thr Leu Met Ala Ala Val Pro 
    370                 375                 380                 


Glu Ile Met Asp Arg Ile Tyr Lys Asn Val Met Asn Lys Val Ser Glu 
385                 390                 395                 400 


Met Ser Ser Phe Gln Arg Asn Leu Phe Ile Leu Ala Tyr Asn Tyr Lys 
                405                 410                 415     


Met Glu Gln Ile Ser Lys Gly Arg Asn Thr Pro Leu Cys Asp Ser Phe 
            420                 425                 430         


Val Phe Arg Lys Val Arg Ser Leu Leu Gly Gly Asn Ile Arg Leu Leu 
        435                 440                 445             


Leu Cys Gly Gly Ala Pro Leu Ser Ala Thr Thr Gln Arg Phe Met Asn 
    450                 455                 460                 


Ile Cys Phe Cys Cys Pro Val Gly Gln Gly Tyr Gly Leu Thr Glu Ser 
465                 470                 475                 480 


Ala Gly Ala Gly Thr Ile Ser Glu Val Trp Asp Tyr Asn Thr Gly Arg 
                485                 490                 495     


Val Gly Ala Pro Leu Val Cys Cys Glu Ile Lys Leu Lys Asn Trp Glu 
            500                 505                 510         


Glu Gly Gly Tyr Phe Asn Thr Asp Lys Pro His Pro Arg Gly Glu Ile 
        515                 520                 525             


Leu Ile Gly Gly Gln Ser Val Thr Met Gly Tyr Tyr Lys Asn Glu Ala 
    530                 535                 540                 


Lys Thr Lys Ala Asp Phe Phe Glu Asp Glu Asn Gly Gln Arg Trp Leu 
545                 550                 555                 560 


Cys Thr Gly Asp Ile Gly Glu Phe Glu Pro Asp Gly Cys Leu Lys Ile 
                565                 570                 575     


Ile Asp Arg Lys Lys Asp Leu Val Lys Leu Gln Ala Gly Glu Tyr Val 
            580                 585                 590         


Ser Leu Gly Lys Val Glu Ala Ala Leu Lys Asn Leu Pro Leu Val Asp 
        595                 600                 605             


Asn Ile Cys Ala Tyr Ala Asn Ser Tyr His Ser Tyr Val Ile Gly Phe 
    610                 615                 620                 


Val Val Pro Asn Gln Lys Glu Leu Thr Glu Leu Ala Arg Lys Lys Gly 
625                 630                 635                 640 


Leu Lys Gly Thr Trp Glu Glu Leu Cys Asn Ser Cys Glu Met Glu Asn 
                645                 650                 655     


Glu Val Leu Lys Val Leu Ser Glu Ala Ala Ile Ser Ala Ser Leu Glu 
            660                 665                 670         


Lys Phe Glu Ile Pro Val Lys Ile Arg Leu Ser Pro Glu Pro Trp Thr 
        675                 680                 685             


Pro Glu Thr Gly Leu Val Thr Asp Ala Phe Lys Leu Lys Arg Lys Glu 
    690                 695                 700                 


Leu Lys Thr His Tyr Gln Ala Asp Ile Glu Arg Met Tyr Gly Arg Lys 
705                 710                 715                 720 


<210>  3055
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  3055

Met Lys Thr Trp Val Lys Ile Val Phe Gly Val Ala Thr Ser Ala Val 
1               5                   10                  15      


Leu Ala Leu Leu Val Met Cys Ile Val Leu Arg Pro Ser Arg Val His 
            20                  25                  30          


Asn Ser Glu Glu Asn Thr Met Arg Ala Leu Thr Leu Lys Asp Ile Leu 
        35                  40                  45              


Asn Gly Thr Phe Ser Tyr Lys Thr Phe Phe Pro Asn Trp Ile Ser Gly 
    50                  55                  60                  


Gln Glu Tyr Leu His Gln Ser Ala Asp Asn Asn Ile Val Leu Tyr Asn 
65                  70                  75                  80  


Ile Glu Thr Gly Gln Ser Tyr Thr Ile Leu Ser Asn Arg Thr Met Lys 
                85                  90                  95      


Ser Val Asn Ala Ser Asn Tyr Gly Leu Ser Pro Asp Arg Gln Phe Val 
            100                 105                 110         


Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp Arg Tyr Ser Tyr Thr Ala 
        115                 120                 125             


Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn Gly Glu Phe Val Arg Gly Asn 
    130                 135                 140                 


Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys Trp Ser Pro Val Gly Ser 
145                 150                 155                 160 


Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile Tyr Leu Lys Gln Arg Pro 
                165                 170                 175     


Gly Asp Pro Pro Phe Gln Ile Thr Phe Asn Gly Arg Glu Asn Lys Ile 
            180                 185                 190         


Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu Glu Glu Met Leu Ala Thr 
        195                 200                 205             


Lys Tyr Ala Leu Trp Trp Ser Pro Asn Gly Lys Phe Leu Ala Tyr Ala 
    210                 215                 220                 


Glu Phe Asn Asp Thr Asp Ile Pro Val Ile Ala Tyr Ser Tyr Tyr Gly 
225                 230                 235                 240 


Asp Glu Gln Tyr Pro Arg Thr Ile Asn Ile Pro Tyr Pro Lys Ala Gly 
                245                 250                 255     


Ala Lys Asn Pro Val Val Arg Ile Phe Ile Ile Asp Thr Thr Tyr Pro 
            260                 265                 270         


Ala Tyr Val Gly Pro Gln Glu Val Pro Val Pro Ala Met Ile Ala Ser 
        275                 280                 285             


Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp Val Thr Asp Glu Arg Val 
    290                 295                 300                 


Cys Leu Gln Trp Leu Lys Arg Val Gln Asn Val Ser Val Leu Ser Ile 
305                 310                 315                 320 


Cys Asp Phe Arg Glu Asp Trp Gln Thr Trp Asp Cys Pro Lys Thr Gln 
                325                 330                 335     


Glu His Ile Glu Glu Ser Arg Thr Gly Trp Ala Gly Gly Phe Phe Val 
            340                 345                 350         


Ser Thr Pro Val Phe Ser Tyr Asp Ala Ile Ser Tyr Tyr Lys Ile Phe 
        355                 360                 365             


Ser Asp Lys Asp Gly Tyr Lys His Ile His Tyr Ile Lys Asp Thr Val 
    370                 375                 380                 


Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys Trp Glu Ala Ile Asn Ile 
385                 390                 395                 400 


Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr Ser Ser Asn Glu Phe Glu 
                405                 410                 415     


Glu Tyr Pro Gly Arg Arg Asn Ile Tyr Arg Ile Ser Ile Gly Ser Tyr 
            420                 425                 430         


Pro Pro Ser Lys Lys Cys Val Thr Cys His Leu Arg Lys Glu Arg Cys 
        435                 440                 445             


Gln Tyr Tyr Thr Ala Ser Phe Ser Asp Tyr Ala Lys Tyr Tyr Ala Leu 
    450                 455                 460                 


Val Cys Tyr Gly Pro Gly Ile Pro Ile Ser Thr Leu His Asp Gly Arg 
465                 470                 475                 480 


Thr Asp Gln Glu Ile Lys Ile Leu Glu Glu Asn Lys Glu Leu Glu Asn 
                485                 490                 495     


Ala Leu Lys Asn Ile Gln Leu Pro Lys Glu Glu Ile Lys Lys Leu Glu 
            500                 505                 510         


Val Asp Glu Ile Thr Leu Trp Tyr Lys Met Ile Leu Pro Pro Gln Phe 
        515                 520                 525             


Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile Gln Val Tyr Gly Gly Pro 
    530                 535                 540                 


Cys Ser Gln Ser Val Arg Ser Val Phe Ala Val Asn Trp Ile Ser Tyr 
545                 550                 555                 560 


Leu Ala Ser Lys Glu Gly Met Val Ile Ala Leu Val Asp Gly Arg Gly 
                565                 570                 575     


Thr Ala Phe Gln Gly Asp Lys Leu Leu Tyr Ala Val Tyr Arg Lys Leu 
            580                 585                 590         


Gly Val Tyr Glu Val Glu Asp Gln Ile Thr Ala Val Arg Lys Phe Ile 
        595                 600                 605             


Glu Met Gly Phe Ile Asp Glu Lys Arg Ile Ala Ile Trp Gly Trp Ser 
    610                 615                 620                 


Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu Ala Ser Gly Thr Gly Leu 
625                 630                 635                 640 


Phe Lys Cys Gly Ile Ala Val Ala Pro Val Ser Ser Trp Glu Tyr Tyr 
                645                 650                 655     


Ala Ser Val Tyr Thr Glu Arg Phe Met Gly Leu Pro Thr Lys Asp Asp 
            660                 665                 670         


Asn Leu Glu His Tyr Lys Asn Ser Thr Val Met Ala Arg Ala Glu Tyr 
        675                 680                 685             


Phe Arg Asn Val Asp Tyr Leu Leu Ile His Gly Thr Ala Asp Asp Asn 
    690                 695                 700                 


Val His Phe Gln Asn Ser Ala Gln Ile Ala Lys Ala Leu Val Asn Ala 
705                 710                 715                 720 


Gln Val Asp Phe Gln Ala Met Trp Tyr Ser Asp Gln Asn His Gly Leu 
                725                 730                 735     


Ser Gly Leu Ser Thr Asn His Leu Tyr Thr His Met Thr His Phe Leu 
            740                 745                 750         


Lys Gln Cys Phe Ser Leu Ser Asp 
        755                 760 


<210>  3056
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  3056

Met Trp Lys Trp Ile Leu Thr His Cys Ala Ser Ala Phe Pro His Leu 
1               5                   10                  15      


Pro Gly Cys Cys Cys Cys Cys Phe Leu Leu Leu Phe Leu Val Ser Ser 
            20                  25                  30          


Val Pro Val Thr Cys Gln Ala Leu Gly Gln Asp Met Val Ser Pro Glu 
        35                  40                  45              


Ala Thr Asn Ser Ser Ser Ser Ser Phe Ser Ser Pro Ser Ser Ala Gly 
    50                  55                  60                  


Arg His Val Arg Ser Tyr Asn His Leu Gln Gly Asp Val Arg Trp Arg 
65                  70                  75                  80  


Lys Leu Phe Ser Phe Thr Lys Tyr Phe Leu Lys Ile Glu Lys Asn Gly 
                85                  90                  95      


Lys Val Ser Gly Thr Lys Lys Glu Asn Cys Pro Tyr Ser Ile Leu Glu 
            100                 105                 110         


Ile Thr Ser Val Glu Ile Gly Val Val Ala Val Lys Ala Ile Asn Ser 
        115                 120                 125             


Asn Tyr Tyr Leu Ala Met Asn Lys Lys Gly Lys Leu Tyr Gly Ser Lys 
    130                 135                 140                 


Glu Phe Asn Asn Asp Cys Lys Leu Lys Glu Arg Ile Glu Glu Asn Gly 
145                 150                 155                 160 


Tyr Asn Thr Tyr Ala Ser Phe Asn Trp Gln His Asn Gly Arg Gln Met 
                165                 170                 175     


Tyr Val Ala Leu Asn Gly Lys Gly Ala Pro Arg Arg Gly Gln Lys Thr 
            180                 185                 190         


Arg Arg Lys Asn Thr Ser Ala His Phe Leu Pro Met Val Val His Ser 
        195                 200                 205             


<210>  3057
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  3057

Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg 
1               5                   10                  15      


Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe 
            20                  25                  30          


Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Asn Glu 
        35                  40                  45              


Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu 
    50                  55                  60                  


Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile 
65                  70                  75                  80  


Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile 
                85                  90                  95      


Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His 
            100                 105                 110         


Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile 
        115                 120                 125             


Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe 
    130                 135                 140                 


Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro 
145                 150                 155                 160 


Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr 
                165                 170                 175     


Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met 
            180                 185                 190         


Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val 
        195                 200                 205             


Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly 
    210                 215                 220                 


Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys 
225                 230                 235                 240 


Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly 
                245                 250                 255     


Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr 
            260                 265                 270         


Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly 
        275                 280                 285             


Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys 
    290                 295                 300                 


Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg 
305                 310                 315                 320 


Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn 
                325                 330                 335     


Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val 
            340                 345                 350         


Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro 
        355                 360                 365             


Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly 
    370                 375                 380                 


Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg 
385                 390                 395                 400 


Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile 
                405                 410                 415     


Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr 
            420                 425                 430         


Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala 
        435                 440                 445             


Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val 
    450                 455                 460                 


Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu 
465                 470                 475                 480 


Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser 
                485                 490                 495     


Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile 
            500                 505                 510         


Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu 
        515                 520                 525             


Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn 
    530                 535                 540                 


Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu 
545                 550                 555                 560 


Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val 
                565                 570                 575     


Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val 
            580                 585                 590         


Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala 
        595                 600                 605             


Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr 
    610                 615                 620                 


Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr 
625                 630                 635                 640 


Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser 
                645                 650                 655     


Asn Pro Ile Val Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu Glu 
            660                 665                 670         


Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg 
        675                 680                 685             


His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser 
    690                 695                 700                 


Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp 
705                 710                 715                 720 


Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala Ala 
                725                 730                 735     


Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
            740                 745                 750 


<210>  3058
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  3058

Met Asn Asn Ala Gly His Gly Pro Thr Arg Arg Leu Arg Gly Leu Gly 
1               5                   10                  15      


Val Leu Ala Gly Val Ala Leu Leu Ala Ala Leu Trp Leu Leu Trp Leu 
            20                  25                  30          


Leu Gly Ser Ala Pro Arg Gly Thr Pro Ala Pro Gln Pro Thr Ile Thr 
        35                  40                  45              


Ile Leu Val Trp His Trp Pro Phe Thr Asp Gln Pro Pro Glu Leu Pro 
    50                  55                  60                  


Ser Asp Thr Cys Thr Arg Tyr Gly Ile Ala Arg Cys His Leu Ser Ala 
65                  70                  75                  80  


Asn Arg Ser Leu Leu Ala Ser Ala Asp Ala Val Val Phe His His Arg 
                85                  90                  95      


Glu Leu Gln Thr Arg Arg Ser His Leu Pro Leu Ala Gln Arg Pro Arg 
            100                 105                 110         


Gly Gln Pro Trp Val Trp Ala Ser Met Glu Ser Pro Ser His Thr His 
        115                 120                 125             


Gly Leu Ser His Leu Arg Gly Ile Phe Asn Trp Val Leu Ser Tyr Arg 
    130                 135                 140                 


Arg Asp Ser Asp Ile Phe Val Pro Tyr Gly Arg Leu Glu Pro His Trp 
145                 150                 155                 160 


Gly Pro Ser Pro Pro Leu Pro Ala Lys Ser Arg Val Ala Ala Trp Val 
                165                 170                 175     


Val Ser Asn Phe Gln Glu Arg Gln Leu Arg Ala Arg Leu Tyr Arg Gln 
            180                 185                 190         


Leu Ala Pro His Leu Arg Val Asp Val Phe Gly Arg Ala Asn Gly Arg 
        195                 200                 205             


Pro Leu Cys Ala Ser Cys Leu Val Pro Thr Val Ala Gln Tyr Arg Phe 
    210                 215                 220                 


Tyr Leu Ser Phe Glu Asn Ser Gln His Arg Asp Tyr Ile Thr Glu Lys 
225                 230                 235                 240 


Phe Trp Arg Asn Ala Leu Val Ala Gly Thr Val Pro Val Val Leu Gly 
                245                 250                 255     


Pro Pro Arg Ala Thr Tyr Glu Ala Phe Val Pro Ala Asp Ala Phe Val 
            260                 265                 270         


His Val Asp Asp Phe Gly Ser Ala Arg Glu Leu Ala Ala Phe Leu Thr 
        275                 280                 285             


Gly Met Asn Glu Ser Arg Tyr Gln Arg Phe Phe Ala Trp Arg Asp Arg 
    290                 295                 300                 


Leu Arg Val Arg Leu Phe Thr Asp Trp Arg Glu Arg Phe Cys Ala Ile 
305                 310                 315                 320 


Cys Asp Arg Tyr Pro His Leu Pro Arg Ser Gln Val Tyr Glu Asp Leu 
                325                 330                 335     


Glu Gly Trp Phe Gln Ala 
            340         


<210>  3059
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  3059

Met Thr Asp Leu Tyr Tyr Leu Ser Gln Thr Asp Gly Ala Gly Asp Trp 
1               5                   10                  15      


Arg Glu Lys Glu Ala Lys Asp Leu Thr Glu Leu Val Gln Arg Arg Ile 
            20                  25                  30          


Thr Tyr Leu Gln Asn Pro Lys Asp Cys Ser Lys Ala Lys Lys Leu Val 
        35                  40                  45              


Cys Asn Ile Asn Lys Gly Cys Gly Tyr Gly Cys Gln Leu His His Val 
    50                  55                  60                  


Val Tyr Cys Phe Met Ile Ala Tyr Gly Thr Gln Arg Thr Leu Ile Leu 
65                  70                  75                  80  


Glu Ser Gln Asn Trp Arg Tyr Ala Thr Gly Gly Trp Glu Thr Val Phe 
                85                  90                  95      


Arg Pro Val Ser Glu Thr Cys Thr Asp Arg Ser Gly Ile Ser Thr Gly 
            100                 105                 110         


His Trp Ser Gly Glu Val Lys Asp Lys Asn Val Gln Val Val Glu Leu 
        115                 120                 125             


Pro Ile Val Asp Ser Leu His Pro Arg Pro Pro Tyr Leu Pro Leu Ala 
    130                 135                 140                 


Val Pro Glu Asp Leu Ala Asp Arg Leu Val Arg Val His Gly Asp Pro 
145                 150                 155                 160 


Ala Val Trp Trp Val Ser Gln Phe Val Lys Tyr Leu Ile Arg Pro Gln 
                165                 170                 175     


Pro Trp Leu Glu Lys Glu Ile Glu Glu Ala Thr Lys Lys Leu Gly Phe 
            180                 185                 190         


Lys His Pro Val Ile Gly Val His Val Arg Arg Thr Asp Lys Val Gly 
        195                 200                 205             


Thr Glu Ala Ala Phe His Pro Ile Glu Glu Tyr Met Val His Val Glu 
    210                 215                 220                 


Glu His Phe Gln Leu Leu Ala Arg Arg Met Gln Val Asp Lys Lys Arg 
225                 230                 235                 240 


Val Tyr Leu Ala Thr Asp Asp Pro Ser Leu Leu Lys Glu Ala Lys Thr 
                245                 250                 255     


Lys Tyr Pro Asn Tyr Glu Phe Ile Ser Asp Asn Ser Ile Ser Trp Ser 
            260                 265                 270         


Ala Gly Leu His Asn Arg Tyr Thr Glu Asn Ser Leu Arg Gly Val Ile 
        275                 280                 285             


Leu Asp Ile His Phe Leu Ser Gln Ala Asp Phe Leu Val Cys Thr Phe 
    290                 295                 300                 


Ser Ser Gln Val Cys Arg Val Ala Tyr Glu Ile Met Gln Thr Leu His 
305                 310                 315                 320 


Pro Asp Ala Ser Ala Asn Phe His Ser Leu Asp Asp Ile Tyr Tyr Phe 
                325                 330                 335     


Gly Gly Gln Asn Ala His Asn Gln Ile Ala Ile Tyr Ala His Gln Pro 
            340                 345                 350         


Arg Thr Ala Asp Glu Ile Pro Met Glu Pro Gly Asp Ile Ile Gly Val 
        355                 360                 365             


Ala Gly Asn His Trp Asp Gly Tyr Ser Lys Gly Val Asn Arg Lys Leu 
    370                 375                 380                 


Gly Arg Thr Gly Leu Tyr Pro Ser Tyr Lys Val Arg Glu Lys Ile Glu 
385                 390                 395                 400 


Thr Val Lys Tyr Pro Thr Tyr Pro Glu Ala Glu Lys 
                405                 410         


<210>  3060
<211>  571
<212>  PRT
<213>  Homo sapiens

<400>  3060

Met Arg Arg Arg Ser Arg Met Leu Leu Cys Phe Ala Phe Leu Trp Val 
1               5                   10                  15      


Leu Gly Ile Ala Tyr Tyr Met Tyr Ser Gly Gly Gly Ser Ala Leu Ala 
            20                  25                  30          


Gly Gly Ala Gly Gly Gly Ala Gly Arg Lys Glu Asp Trp Asn Glu Ile 
        35                  40                  45              


Asp Pro Ile Lys Lys Lys Asp Leu His His Ser Asn Gly Glu Glu Lys 
    50                  55                  60                  


Ala Gln Ser Met Glu Thr Leu Pro Pro Gly Lys Val Arg Trp Pro Asp 
65                  70                  75                  80  


Phe Asn Gln Glu Ala Tyr Val Gly Gly Thr Met Val Arg Ser Gly Gln 
                85                  90                  95      


Asp Pro Tyr Ala Arg Asn Lys Phe Asn Gln Val Glu Ser Asp Lys Leu 
            100                 105                 110         


Arg Met Asp Arg Ala Ile Pro Asp Thr Arg His Asp Gln Cys Gln Arg 
        115                 120                 125             


Lys Gln Trp Arg Val Asp Leu Pro Ala Thr Ser Val Val Ile Thr Phe 
    130                 135                 140                 


His Asn Glu Ala Arg Ser Ala Leu Leu Arg Thr Val Val Ser Val Leu 
145                 150                 155                 160 


Lys Lys Ser Pro Pro His Leu Ile Lys Glu Ile Ile Leu Val Asp Asp 
                165                 170                 175     


Tyr Ser Asn Asp Pro Glu Asp Gly Ala Leu Leu Gly Lys Ile Glu Lys 
            180                 185                 190         


Val Arg Val Leu Arg Asn Asp Arg Arg Glu Gly Leu Met Arg Ser Arg 
        195                 200                 205             


Val Arg Gly Ala Asp Ala Ala Gln Ala Lys Val Leu Thr Phe Leu Asp 
    210                 215                 220                 


Ser His Cys Glu Cys Asn Glu His Trp Leu Glu Pro Leu Leu Glu Arg 
225                 230                 235                 240 


Val Ala Glu Asp Arg Thr Arg Val Val Ser Pro Ile Ile Asp Val Ile 
                245                 250                 255     


Asn Met Asp Asn Phe Gln Tyr Val Gly Ala Ser Ala Asp Leu Lys Gly 
            260                 265                 270         


Gly Phe Asp Trp Asn Leu Val Phe Lys Trp Asp Tyr Met Thr Pro Glu 
        275                 280                 285             


Gln Arg Arg Ser Arg Gln Gly Asn Pro Val Ala Pro Ile Lys Thr Pro 
    290                 295                 300                 


Met Ile Ala Gly Gly Leu Phe Val Met Asp Lys Phe Tyr Phe Glu Glu 
305                 310                 315                 320 


Leu Gly Lys Tyr Asp Met Met Met Asp Val Trp Gly Gly Glu Asn Leu 
                325                 330                 335     


Glu Ile Ser Phe Arg Val Trp Gln Cys Gly Gly Ser Leu Glu Ile Ile 
            340                 345                 350         


Pro Cys Ser Arg Val Gly His Val Phe Arg Lys Gln His Pro Tyr Thr 
        355                 360                 365             


Phe Pro Gly Gly Ser Gly Thr Val Phe Ala Arg Asn Thr Arg Arg Ala 
    370                 375                 380                 


Ala Glu Val Trp Met Asp Glu Tyr Lys Asn Phe Tyr Tyr Ala Ala Val 
385                 390                 395                 400 


Pro Ser Ala Arg Asn Val Pro Tyr Gly Asn Ile Gln Ser Arg Leu Glu 
                405                 410                 415     


Leu Arg Lys Lys Leu Ser Cys Lys Pro Phe Lys Trp Tyr Leu Glu Asn 
            420                 425                 430         


Val Tyr Pro Glu Leu Arg Val Pro Asp His Gln Asp Ile Ala Phe Gly 
        435                 440                 445             


Ala Leu Gln Gln Gly Thr Asn Cys Leu Asp Thr Leu Gly His Phe Ala 
    450                 455                 460                 


Asp Gly Val Val Gly Val Tyr Glu Cys His Asn Ala Gly Gly Asn Gln 
465                 470                 475                 480 


Glu Trp Ala Leu Thr Lys Glu Lys Ser Val Lys His Met Asp Leu Cys 
                485                 490                 495     


Leu Thr Val Val Asp Arg Ala Pro Gly Ser Leu Ile Lys Leu Gln Gly 
            500                 505                 510         


Cys Arg Glu Asn Asp Ser Arg Gln Lys Trp Glu Gln Ile Glu Gly Asn 
        515                 520                 525             


Ser Lys Leu Arg His Val Gly Ser Asn Leu Cys Leu Asp Ser Arg Thr 
    530                 535                 540                 


Ala Lys Ser Gly Gly Leu Ser Val Glu Val Cys Gly Pro Ala Leu Ser 
545                 550                 555                 560 


Gln Gln Trp Lys Phe Thr Leu Asn Leu Gln Gln 
                565                 570     


<210>  3061
<211>  633
<212>  PRT
<213>  Homo sapiens

<400>  3061

Met Ala His Leu Lys Arg Leu Val Lys Leu His Ile Lys Arg His Tyr 
1               5                   10                  15      


His Lys Lys Phe Trp Lys Leu Gly Ala Val Ile Phe Phe Phe Ile Ile 
            20                  25                  30          


Val Leu Val Leu Met Gln Arg Glu Val Ser Val Gln Tyr Ser Lys Glu 
        35                  40                  45              


Glu Ser Arg Met Glu Arg Asn Met Lys Asn Lys Asn Lys Met Leu Asp 
    50                  55                  60                  


Leu Met Leu Glu Ala Val Asn Asn Ile Lys Asp Ala Met Pro Lys Met 
65                  70                  75                  80  


Gln Ile Gly Ala Pro Val Arg Gln Asn Ile Asp Ala Gly Glu Arg Pro 
                85                  90                  95      


Cys Leu Gln Gly Tyr Tyr Thr Ala Ala Glu Leu Lys Pro Val Leu Asp 
            100                 105                 110         


Arg Pro Pro Gln Asp Ser Asn Ala Pro Gly Ala Ser Gly Lys Ala Phe 
        115                 120                 125             


Lys Thr Thr Asn Leu Ser Val Glu Glu Gln Lys Glu Lys Glu Arg Gly 
    130                 135                 140                 


Glu Ala Lys His Cys Phe Asn Ala Phe Ala Ser Asp Arg Ile Ser Leu 
145                 150                 155                 160 


His Arg Asp Leu Gly Pro Asp Thr Arg Pro Pro Glu Cys Ile Glu Gln 
                165                 170                 175     


Lys Phe Lys Arg Cys Pro Pro Leu Pro Thr Thr Ser Val Ile Ile Val 
            180                 185                 190         


Phe His Asn Glu Ala Trp Ser Thr Leu Leu Arg Thr Val His Ser Val 
        195                 200                 205             


Leu Tyr Ser Ser Pro Ala Ile Leu Leu Lys Glu Ile Ile Leu Val Asp 
    210                 215                 220                 


Asp Ala Ser Val Asp Glu Tyr Leu His Asp Lys Leu Asp Glu Tyr Val 
225                 230                 235                 240 


Lys Gln Phe Ser Ile Val Lys Ile Val Arg Gln Arg Glu Arg Lys Gly 
                245                 250                 255     


Leu Ile Thr Ala Arg Leu Leu Gly Ala Thr Val Ala Thr Ala Glu Thr 
            260                 265                 270         


Leu Thr Phe Leu Asp Ala His Cys Glu Cys Phe Tyr Gly Trp Leu Glu 
        275                 280                 285             


Pro Leu Leu Ala Arg Ile Ala Glu Asn Tyr Thr Ala Val Val Ser Pro 
    290                 295                 300                 


Asp Ile Ala Ser Ile Asp Leu Asn Thr Phe Glu Phe Asn Lys Pro Ser 
305                 310                 315                 320 


Pro Tyr Gly Ser Asn His Asn Arg Gly Asn Phe Asp Trp Ser Leu Ser 
                325                 330                 335     


Phe Gly Trp Glu Ser Leu Pro Asp His Glu Lys Gln Arg Arg Lys Asp 
            340                 345                 350         


Glu Thr Tyr Pro Ile Lys Thr Pro Thr Phe Ala Gly Gly Leu Phe Ser 
        355                 360                 365             


Ile Ser Lys Glu Tyr Phe Glu Tyr Ile Gly Ser Tyr Asp Glu Glu Met 
    370                 375                 380                 


Glu Ile Trp Gly Gly Glu Asn Ile Glu Met Ser Phe Arg Val Trp Gln 
385                 390                 395                 400 


Cys Gly Gly Gln Leu Glu Ile Met Pro Cys Ser Val Val Gly His Val 
                405                 410                 415     


Phe Arg Ser Lys Ser Pro His Ser Phe Pro Lys Gly Thr Gln Val Ile 
            420                 425                 430         


Ala Arg Asn Gln Val Arg Leu Ala Glu Val Trp Met Asp Glu Tyr Lys 
        435                 440                 445             


Glu Ile Phe Tyr Arg Arg Asn Thr Asp Ala Ala Lys Ile Val Lys Gln 
    450                 455                 460                 


Lys Ala Phe Gly Asp Leu Ser Lys Arg Phe Glu Ile Lys His Arg Leu 
465                 470                 475                 480 


Gln Cys Lys Asn Phe Thr Trp Tyr Leu Asn Asn Ile Tyr Pro Glu Val 
                485                 490                 495     


Tyr Val Pro Asp Leu Asn Pro Val Ile Ser Gly Tyr Ile Lys Ser Val 
            500                 505                 510         


Gly Gln Pro Leu Cys Leu Asp Val Gly Glu Asn Asn Gln Gly Gly Lys 
        515                 520                 525             


Pro Leu Ile Met Tyr Thr Cys His Gly Leu Gly Gly Asn Gln Tyr Phe 
    530                 535                 540                 


Glu Tyr Ser Ala Gln His Glu Ile Arg His Asn Ile Gln Lys Glu Leu 
545                 550                 555                 560 


Cys Leu His Ala Ala Gln Gly Leu Val Gln Leu Lys Ala Cys Thr Tyr 
                565                 570                 575     


Lys Gly His Lys Thr Val Val Thr Gly Glu Gln Ile Trp Glu Ile Gln 
            580                 585                 590         


Lys Asp Gln Leu Leu Tyr Asn Pro Phe Leu Lys Met Cys Leu Ser Ala 
        595                 600                 605             


Asn Gly Glu His Pro Ser Leu Val Ser Cys Asn Pro Ser Asp Pro Leu 
    610                 615                 620                 


Gln Lys Trp Ile Leu Ser Gln Asn Asp 
625                 630             


<210>  3062
<211>  580
<212>  PRT
<213>  Homo sapiens

<400>  3062

Met Ala Gly Thr Val Arg Thr Ala Cys Leu Val Val Ala Met Leu Leu 
1               5                   10                  15      


Ser Leu Asp Phe Pro Gly Gln Ala Gln Pro Pro Pro Pro Pro Pro Asp 
            20                  25                  30          


Ala Thr Cys His Gln Val Arg Ser Phe Phe Gln Arg Leu Gln Pro Gly 
        35                  40                  45              


Leu Lys Trp Val Pro Glu Thr Pro Val Pro Gly Ser Asp Leu Gln Val 
    50                  55                  60                  


Cys Leu Pro Lys Gly Pro Thr Cys Cys Ser Arg Lys Met Glu Glu Lys 
65                  70                  75                  80  


Tyr Gln Leu Thr Ala Arg Leu Asn Met Glu Gln Leu Leu Gln Ser Ala 
                85                  90                  95      


Ser Met Glu Leu Lys Phe Leu Ile Ile Gln Asn Ala Ala Val Phe Gln 
            100                 105                 110         


Glu Ala Phe Glu Ile Val Val Arg His Ala Lys Asn Tyr Thr Asn Ala 
        115                 120                 125             


Met Phe Lys Asn Asn Tyr Pro Ser Leu Thr Pro Gln Ala Phe Glu Phe 
    130                 135                 140                 


Val Gly Glu Phe Phe Thr Asp Val Ser Leu Tyr Ile Leu Gly Ser Asp 
145                 150                 155                 160 


Ile Asn Val Asp Asp Met Val Asn Glu Leu Phe Asp Ser Leu Phe Pro 
                165                 170                 175     


Val Ile Tyr Thr Gln Leu Met Asn Pro Gly Leu Pro Asp Ser Ala Leu 
            180                 185                 190         


Asp Ile Asn Glu Cys Leu Arg Gly Ala Arg Arg Asp Leu Lys Val Phe 
        195                 200                 205             


Gly Asn Phe Pro Lys Leu Ile Met Thr Gln Val Ser Lys Ser Leu Gln 
    210                 215                 220                 


Val Thr Arg Ile Phe Leu Gln Ala Leu Asn Leu Gly Ile Glu Val Ile 
225                 230                 235                 240 


Asn Thr Thr Asp His Leu Lys Phe Ser Lys Asp Cys Gly Arg Met Leu 
                245                 250                 255     


Thr Arg Met Trp Tyr Cys Ser Tyr Cys Gln Gly Leu Met Met Val Lys 
            260                 265                 270         


Pro Cys Gly Gly Tyr Cys Asn Val Val Met Gln Gly Cys Met Ala Gly 
        275                 280                 285             


Val Val Glu Ile Asp Lys Tyr Trp Arg Glu Tyr Ile Leu Ser Leu Glu 
    290                 295                 300                 


Glu Leu Val Asn Gly Met Tyr Arg Ile Tyr Asp Met Glu Asn Val Leu 
305                 310                 315                 320 


Leu Gly Leu Phe Ser Thr Ile His Asp Ser Ile Gln Tyr Val Gln Lys 
                325                 330                 335     


Asn Ala Gly Lys Leu Thr Thr Thr Ile Gly Lys Leu Cys Ala His Ser 
            340                 345                 350         


Gln Gln Arg Gln Tyr Arg Ser Ala Tyr Tyr Pro Glu Asp Leu Phe Ile 
        355                 360                 365             


Asp Lys Lys Val Leu Lys Val Ala His Val Glu His Glu Glu Thr Leu 
    370                 375                 380                 


Ser Ser Arg Arg Arg Glu Leu Ile Gln Lys Leu Lys Ser Phe Ile Ser 
385                 390                 395                 400 


Phe Tyr Ser Ala Leu Pro Gly Tyr Ile Cys Ser His Ser Pro Val Ala 
                405                 410                 415     


Glu Asn Asp Thr Leu Cys Trp Asn Gly Gln Glu Leu Val Glu Arg Tyr 
            420                 425                 430         


Ser Gln Lys Ala Ala Arg Asn Gly Met Lys Asn Gln Phe Asn Leu His 
        435                 440                 445             


Glu Leu Lys Met Lys Gly Pro Glu Pro Val Val Ser Gln Ile Ile Asp 
    450                 455                 460                 


Lys Leu Lys His Ile Asn Gln Leu Leu Arg Thr Met Ser Met Pro Lys 
465                 470                 475                 480 


Gly Arg Val Leu Asp Lys Asn Leu Asp Glu Glu Gly Phe Glu Ser Gly 
                485                 490                 495     


Asp Cys Gly Asp Asp Glu Asp Glu Cys Ile Gly Gly Ser Gly Asp Gly 
            500                 505                 510         


Met Ile Lys Val Lys Asn Gln Leu Arg Phe Leu Ala Glu Leu Ala Tyr 
        515                 520                 525             


Asp Leu Asp Val Asp Asp Ala Pro Gly Asn Ser Gln Gln Ala Thr Pro 
    530                 535                 540                 


Lys Asp Asn Glu Ile Ser Thr Phe His Asn Leu Gly Asn Val His Ser 
545                 550                 555                 560 


Pro Leu Lys Leu Leu Thr Ser Met Ala Ile Ser Val Val Cys Phe Phe 
                565                 570                 575     


Phe Leu Val His 
            580 


<210>  3063
<211>  3259
<212>  PRT
<213>  Homo sapiens

<400>  3063

Met Leu Ser Arg Leu Ser Gly Leu Ala Asn Val Val Leu His Glu Leu 
1               5                   10                  15      


Ser Gly Asp Asp Asp Thr Asp Gln Asn Met Arg Ala Pro Leu Asp Pro 
            20                  25                  30          


Glu Leu His Gln Glu Ser Asp Met Glu Phe Asn Asn Thr Thr Gln Glu 
        35                  40                  45              


Asp Val Gln Glu Arg Leu Ala Tyr Ala Glu Gln Leu Val Val Glu Leu 
    50                  55                  60                  


Lys Asp Ile Ile Arg Gln Lys Asp Val Gln Leu Gln Gln Lys Asp Glu 
65                  70                  75                  80  


Ala Leu Gln Glu Glu Arg Lys Ala Ala Asp Asn Lys Ile Lys Lys Leu 
                85                  90                  95      


Lys Leu His Ala Lys Ala Lys Leu Thr Ser Leu Asn Lys Tyr Ile Glu 
            100                 105                 110         


Glu Met Lys Ala Gln Gly Gly Thr Val Leu Pro Thr Glu Pro Gln Ser 
        115                 120                 125             


Glu Glu Gln Leu Ser Lys His Asp Lys Ser Ser Thr Glu Glu Glu Met 
    130                 135                 140                 


Glu Ile Glu Lys Ile Lys His Lys Leu Gln Glu Lys Glu Glu Leu Ile 
145                 150                 155                 160 


Ser Thr Leu Gln Ala Gln Leu Thr Gln Ala Gln Ala Glu Gln Pro Ala 
                165                 170                 175     


Gln Ser Ser Thr Glu Met Glu Glu Phe Val Met Met Lys Gln Gln Leu 
            180                 185                 190         


Gln Glu Lys Glu Glu Phe Ile Ser Thr Leu Gln Ala Gln Leu Ser Gln 
        195                 200                 205             


Thr Gln Ala Glu Gln Ala Ala Gln Gln Val Val Arg Glu Lys Asp Ala 
    210                 215                 220                 


Arg Phe Glu Thr Gln Val Arg Leu His Glu Asp Glu Leu Leu Gln Leu 
225                 230                 235                 240 


Val Thr Gln Ala Asp Val Glu Thr Glu Met Gln Gln Lys Leu Arg Val 
                245                 250                 255     


Leu Gln Arg Lys Leu Glu Glu His Glu Glu Ser Leu Val Gly Arg Ala 
            260                 265                 270         


Gln Val Val Asp Leu Leu Gln Gln Glu Leu Thr Ala Ala Glu Gln Arg 
        275                 280                 285             


Asn Gln Ile Leu Ser Gln Gln Leu Gln Gln Met Glu Ala Glu His Asn 
    290                 295                 300                 


Thr Leu Arg Asn Thr Val Glu Thr Glu Arg Glu Glu Ser Lys Ile Leu 
305                 310                 315                 320 


Leu Glu Lys Met Glu Leu Glu Val Ala Glu Arg Lys Leu Ser Phe His 
                325                 330                 335     


Asn Leu Gln Glu Glu Met His His Leu Leu Glu Gln Phe Glu Gln Ala 
            340                 345                 350         


Gly Gln Ala Gln Ala Glu Leu Glu Ser Arg Tyr Ser Ala Leu Glu Gln 
        355                 360                 365             


Lys His Lys Ala Glu Met Glu Glu Lys Thr Ser His Ile Leu Ser Leu 
    370                 375                 380                 


Gln Lys Thr Gly Gln Glu Leu Gln Ser Ala Cys Asp Ala Leu Lys Asp 
385                 390                 395                 400 


Gln Asn Ser Lys Leu Leu Gln Asp Lys Asn Glu Gln Ala Val Gln Ser 
                405                 410                 415     


Ala Gln Thr Ile Gln Gln Leu Glu Asp Gln Leu Gln Gln Lys Ser Lys 
            420                 425                 430         


Glu Ile Ser Gln Phe Leu Asn Arg Leu Pro Leu Gln Gln His Glu Thr 
        435                 440                 445             


Ala Ser Gln Thr Ser Phe Pro Asp Val Tyr Asn Glu Gly Thr Gln Ala 
    450                 455                 460                 


Val Thr Glu Glu Asn Ile Ala Ser Leu Gln Lys Arg Val Val Glu Leu 
465                 470                 475                 480 


Glu Asn Glu Lys Gly Ala Leu Leu Leu Ser Ser Ile Glu Leu Glu Glu 
                485                 490                 495     


Leu Lys Ala Glu Asn Glu Lys Leu Ser Ser Gln Ile Thr Leu Leu Glu 
            500                 505                 510         


Ala Gln Asn Arg Thr Gly Glu Ala Asp Arg Glu Val Ser Glu Ile Ser 
        515                 520                 525             


Ile Val Asp Ile Ala Asn Lys Arg Ser Ser Ser Ala Glu Glu Ser Gly 
    530                 535                 540                 


Gln Asp Val Leu Glu Asn Thr Phe Ser Gln Lys His Lys Glu Leu Ser 
545                 550                 555                 560 


Val Leu Leu Leu Glu Met Lys Glu Ala Gln Glu Glu Ile Ala Phe Leu 
                565                 570                 575     


Lys Leu Gln Leu Gln Gly Lys Arg Ala Glu Glu Ala Asp His Glu Val 
            580                 585                 590         


Leu Asp Gln Lys Glu Met Lys Gln Met Glu Gly Glu Gly Ile Ala Pro 
        595                 600                 605             


Ile Lys Met Lys Val Phe Leu Glu Asp Thr Gly Gln Asp Phe Pro Leu 
    610                 615                 620                 


Met Pro Asn Glu Glu Ser Ser Leu Pro Ala Val Glu Lys Glu Gln Ala 
625                 630                 635                 640 


Ser Thr Glu His Gln Ser Arg Thr Ser Glu Glu Ile Ser Leu Asn Asp 
                645                 650                 655     


Ala Gly Val Glu Leu Lys Ser Thr Lys Gln Asp Gly Asp Lys Ser Leu 
            660                 665                 670         


Ser Ala Val Pro Asp Ile Gly Gln Cys His Gln Asp Glu Leu Glu Arg 
        675                 680                 685             


Leu Lys Ser Gln Ile Leu Glu Leu Glu Leu Asn Phe His Lys Ala Gln 
    690                 695                 700                 


Glu Ile Tyr Glu Lys Asn Leu Asp Glu Lys Ala Lys Glu Ile Ser Asn 
705                 710                 715                 720 


Leu Asn Gln Leu Ile Glu Glu Phe Lys Lys Asn Ala Asp Asn Asn Ser 
                725                 730                 735     


Ser Ala Phe Thr Ala Leu Ser Glu Glu Arg Asp Gln Leu Leu Ser Gln 
            740                 745                 750         


Val Lys Glu Leu Ser Met Val Thr Glu Leu Arg Ala Gln Val Lys Gln 
        755                 760                 765             


Leu Glu Met Asn Leu Ala Glu Ala Glu Arg Gln Arg Arg Leu Asp Tyr 
    770                 775                 780                 


Glu Ser Gln Thr Ala His Asp Asn Leu Leu Thr Glu Gln Ile His Ser 
785                 790                 795                 800 


Leu Ser Ile Glu Ala Lys Ser Lys Asp Val Lys Ile Glu Val Leu Gln 
                805                 810                 815     


Asn Glu Leu Asp Asp Val Gln Leu Gln Phe Ser Glu Gln Ser Thr Leu 
            820                 825                 830         


Ile Arg Ser Leu Gln Ser Gln Leu Gln Asn Lys Glu Ser Glu Val Leu 
        835                 840                 845             


Glu Gly Ala Glu Arg Val Arg His Ile Ser Ser Lys Val Glu Glu Leu 
    850                 855                 860                 


Ser Gln Ala Leu Ser Gln Lys Glu Leu Glu Ile Thr Lys Met Asp Gln 
865                 870                 875                 880 


Leu Leu Leu Glu Lys Lys Arg Asp Val Glu Thr Leu Gln Gln Thr Ile 
                885                 890                 895     


Glu Glu Lys Asp Gln Gln Val Thr Glu Ile Ser Phe Ser Met Thr Glu 
            900                 905                 910         


Lys Met Val Gln Leu Asn Glu Glu Lys Phe Ser Leu Gly Val Glu Ile 
        915                 920                 925             


Lys Thr Leu Lys Glu Gln Leu Asn Leu Leu Ser Arg Ala Glu Glu Ala 
    930                 935                 940                 


Lys Lys Glu Gln Val Glu Glu Asp Asn Glu Val Ser Ser Gly Leu Lys 
945                 950                 955                 960 


Gln Asn Tyr Asp Glu Met Ser Pro Ala Gly Gln Ile Ser Lys Glu Glu 
                965                 970                 975     


Leu Gln His Glu Phe Asp Leu Leu Lys Lys Glu Asn Glu Gln Arg Lys 
            980                 985                 990         


Arg Lys Leu Gln Ala Ala Leu Ile  Asn Arg Lys Glu Leu  Leu Gln Arg 
        995                 1000                 1005             


Val Ser  Arg Leu Glu Glu Glu  Leu Ala Asn Leu Lys  Asp Glu Ser 
    1010                 1015                 1020             


Lys Lys  Glu Ile Pro Leu Ser  Glu Thr Glu Arg Gly  Glu Val Glu 
    1025                 1030                 1035             


Glu Asp  Lys Glu Asn Lys Glu  Tyr Ser Glu Lys Cys  Val Thr Ser 
    1040                 1045                 1050             


Lys Cys  Gln Glu Ile Glu Ile  Tyr Leu Lys Gln Thr  Ile Ser Glu 
    1055                 1060                 1065             


Lys Glu  Val Glu Leu Gln His  Ile Arg Lys Asp Leu  Glu Glu Lys 
    1070                 1075                 1080             


Leu Ala  Ala Glu Glu Gln Phe  Gln Ala Leu Val Lys  Gln Met Asn 
    1085                 1090                 1095             


Gln Thr  Leu Gln Asp Lys Thr  Asn Gln Ile Asp Leu  Leu Gln Ala 
    1100                 1105                 1110             


Glu Ile  Ser Glu Asn Gln Ala  Ile Ile Gln Lys Leu  Ile Thr Ser 
    1115                 1120                 1125             


Asn Thr  Asp Ala Ser Asp Gly  Asp Ser Val Ala Leu  Val Lys Glu 
    1130                 1135                 1140             


Thr Val  Val Ile Ser Pro Pro  Cys Thr Gly Ser Ser  Glu His Trp 
    1145                 1150                 1155             


Lys Pro  Glu Leu Glu Glu Lys  Ile Leu Ala Leu Glu  Lys Glu Lys 
    1160                 1165                 1170             


Glu Gln  Leu Gln Lys Lys Leu  Gln Glu Ala Leu Thr  Ser Arg Lys 
    1175                 1180                 1185             


Ala Ile  Leu Lys Lys Ala Gln  Glu Lys Glu Arg His  Leu Arg Glu 
    1190                 1195                 1200             


Glu Leu  Lys Gln Gln Lys Asp  Asp Tyr Asn Arg Leu  Gln Glu Gln 
    1205                 1210                 1215             


Phe Asp  Glu Gln Ser Lys Glu  Asn Glu Asn Ile Gly  Asp Gln Leu 
    1220                 1225                 1230             


Arg Gln  Leu Gln Ile Gln Val  Arg Glu Ser Ile Asp  Gly Lys Leu 
    1235                 1240                 1245             


Pro Ser  Thr Asp Gln Gln Glu  Ser Cys Ser Ser Thr  Pro Gly Leu 
    1250                 1255                 1260             


Glu Glu  Pro Leu Phe Lys Ala  Thr Glu Gln His His  Thr Gln Pro 
    1265                 1270                 1275             


Val Leu  Glu Ser Asn Leu Cys  Pro Asp Trp Pro Ser  His Ser Glu 
    1280                 1285                 1290             


Asp Ala  Ser Ala Leu Gln Gly  Gly Thr Ser Val Ala  Gln Ile Lys 
    1295                 1300                 1305             


Ala Gln  Leu Lys Glu Ile Glu  Ala Glu Lys Val Glu  Leu Glu Leu 
    1310                 1315                 1320             


Lys Val  Ser Ser Thr Thr Ser  Glu Leu Thr Lys Lys  Ser Glu Glu 
    1325                 1330                 1335             


Val Phe  Gln Leu Gln Glu Gln  Ile Asn Lys Gln Gly  Leu Glu Ile 
    1340                 1345                 1350             


Glu Ser  Leu Lys Thr Val Ser  His Glu Ala Glu Val  His Ala Glu 
    1355                 1360                 1365             


Ser Leu  Gln Gln Lys Leu Glu  Ser Ser Gln Leu Gln  Ile Ala Gly 
    1370                 1375                 1380             


Leu Glu  His Leu Arg Glu Leu  Gln Pro Lys Leu Asp  Glu Leu Gln 
    1385                 1390                 1395             


Lys Leu  Ile Ser Lys Lys Glu  Glu Asp Val Ser Tyr  Leu Ser Gly 
    1400                 1405                 1410             


Gln Leu  Ser Glu Lys Glu Ala  Ala Leu Thr Lys Ile  Gln Thr Glu 
    1415                 1420                 1425             


Ile Ile  Glu Gln Glu Asp Leu  Ile Lys Ala Leu His  Thr Gln Leu 
    1430                 1435                 1440             


Glu Met  Gln Ala Lys Glu His  Asp Glu Arg Ile Lys  Gln Leu Gln 
    1445                 1450                 1455             


Val Glu  Leu Cys Glu Met Lys  Gln Lys Pro Glu Glu  Ile Gly Glu 
    1460                 1465                 1470             


Glu Ser  Arg Ala Lys Gln Gln  Ile Gln Arg Lys Leu  Gln Ala Ala 
    1475                 1480                 1485             


Leu Ile  Ser Arg Lys Glu Ala  Leu Lys Glu Asn Lys  Ser Leu Gln 
    1490                 1495                 1500             


Glu Glu  Leu Ser Leu Ala Arg  Gly Thr Ile Glu Arg  Leu Thr Lys 
    1505                 1510                 1515             


Ser Leu  Ala Asp Val Glu Ser  Gln Val Ser Ala Gln  Asn Lys Glu 
    1520                 1525                 1530             


Lys Asp  Thr Val Leu Gly Arg  Leu Ala Leu Leu Gln  Glu Glu Arg 
    1535                 1540                 1545             


Asp Lys  Leu Ile Thr Glu Met  Asp Arg Ser Leu Leu  Glu Asn Gln 
    1550                 1555                 1560             


Ser Leu  Ser Ser Ser Cys Glu  Ser Leu Lys Leu Ala  Leu Glu Gly 
    1565                 1570                 1575             


Leu Thr  Glu Asp Lys Glu Lys  Leu Val Lys Glu Ile  Glu Ser Leu 
    1580                 1585                 1590             


Lys Ser  Ser Lys Ile Ala Glu  Ser Thr Glu Trp Gln  Glu Lys His 
    1595                 1600                 1605             


Lys Glu  Leu Gln Lys Glu Tyr  Glu Ile Leu Leu Gln  Ser Tyr Glu 
    1610                 1615                 1620             


Asn Val  Ser Asn Glu Ala Glu  Arg Ile Gln His Val  Val Glu Ala 
    1625                 1630                 1635             


Val Arg  Gln Glu Lys Gln Glu  Leu Tyr Gly Lys Leu  Arg Ser Thr 
    1640                 1645                 1650             


Glu Ala  Asn Lys Lys Glu Thr  Glu Lys Gln Leu Gln  Glu Ala Glu 
    1655                 1660                 1665             


Gln Glu  Met Glu Glu Met Lys  Glu Lys Met Arg Lys  Phe Ala Lys 
    1670                 1675                 1680             


Ser Lys  Gln Gln Lys Ile Leu  Glu Leu Glu Glu Glu  Asn Asp Arg 
    1685                 1690                 1695             


Leu Arg  Ala Glu Val His Pro  Ala Gly Asp Thr Ala  Lys Glu Cys 
    1700                 1705                 1710             


Met Glu  Thr Leu Leu Ser Ser  Asn Ala Ser Met Lys  Glu Glu Leu 
    1715                 1720                 1725             


Glu Arg  Val Lys Met Glu Tyr  Glu Thr Leu Ser Lys  Lys Phe Gln 
    1730                 1735                 1740             


Ser Leu  Met Ser Glu Lys Asp  Ser Leu Ser Glu Glu  Val Gln Asp 
    1745                 1750                 1755             


Leu Lys  His Gln Ile Glu Gly  Asn Val Ser Lys Gln  Ala Asn Leu 
    1760                 1765                 1770             


Glu Ala  Thr Glu Lys His Asp  Asn Gln Thr Asn Val  Thr Glu Glu 
    1775                 1780                 1785             


Gly Thr  Gln Ser Ile Pro Gly  Glu Thr Glu Glu Gln  Asp Ser Leu 
    1790                 1795                 1800             


Ser Met  Ser Thr Arg Pro Thr  Cys Ser Glu Ser Val  Pro Ser Ala 
    1805                 1810                 1815             


Lys Ser  Ala Asn Pro Ala Val  Ser Lys Asp Phe Ser  Ser His Asp 
    1820                 1825                 1830             


Glu Ile  Asn Asn Tyr Leu Gln  Gln Ile Asp Gln Leu  Lys Glu Arg 
    1835                 1840                 1845             


Ile Ala  Gly Leu Glu Glu Glu  Lys Gln Lys Asn Lys  Glu Phe Ser 
    1850                 1855                 1860             


Gln Thr  Leu Glu Asn Glu Lys  Asn Thr Leu Leu Ser  Gln Ile Ser 
    1865                 1870                 1875             


Thr Lys  Asp Gly Glu Leu Lys  Met Leu Gln Glu Glu  Val Thr Lys 
    1880                 1885                 1890             


Met Asn  Leu Leu Asn Gln Gln  Ile Gln Glu Glu Leu  Ser Arg Val 
    1895                 1900                 1905             


Thr Lys  Leu Lys Glu Thr Ala  Glu Glu Glu Lys Asp  Asp Leu Glu 
    1910                 1915                 1920             


Glu Arg  Leu Met Asn Gln Leu  Ala Glu Leu Asn Gly  Ser Ile Gly 
    1925                 1930                 1935             


Asn Tyr  Cys Gln Asp Val Thr  Asp Ala Gln Ile Lys  Asn Glu Leu 
    1940                 1945                 1950             


Leu Glu  Ser Glu Met Lys Asn  Leu Lys Lys Cys Val  Ser Glu Leu 
    1955                 1960                 1965             


Glu Glu  Glu Lys Gln Gln Leu  Val Lys Glu Lys Thr  Lys Val Glu 
    1970                 1975                 1980             


Ser Glu  Ile Arg Lys Glu Tyr  Leu Glu Lys Ile Gln  Gly Ala Gln 
    1985                 1990                 1995             


Lys Glu  Pro Gly Asn Lys Ser  His Ala Lys Glu Leu  Gln Glu Leu 
    2000                 2005                 2010             


Leu Lys  Glu Lys Gln Gln Glu  Val Lys Gln Leu Gln  Lys Asp Cys 
    2015                 2020                 2025             


Ile Arg  Tyr Gln Glu Lys Ile  Ser Ala Leu Glu Arg  Thr Val Lys 
    2030                 2035                 2040             


Ala Leu  Glu Phe Val Gln Thr  Glu Ser Gln Lys Asp  Leu Glu Ile 
    2045                 2050                 2055             


Thr Lys  Glu Asn Leu Ala Gln  Ala Val Glu His Arg  Lys Lys Ala 
    2060                 2065                 2070             


Gln Ala  Glu Leu Ala Ser Phe  Lys Val Leu Leu Asp  Asp Thr Gln 
    2075                 2080                 2085             


Ser Glu  Ala Ala Arg Val Leu  Ala Asp Asn Leu Lys  Leu Lys Lys 
    2090                 2095                 2100             


Glu Leu  Gln Ser Asn Lys Glu  Ser Val Lys Ser Gln  Met Lys Gln 
    2105                 2110                 2115             


Lys Asp  Glu Asp Leu Glu Arg  Arg Leu Glu Gln Ala  Glu Glu Lys 
    2120                 2125                 2130             


His Leu  Lys Glu Lys Lys Asn  Met Gln Glu Lys Leu  Asp Ala Leu 
    2135                 2140                 2145             


Arg Arg  Glu Lys Val His Leu  Glu Glu Thr Ile Gly  Glu Ile Gln 
    2150                 2155                 2160             


Val Thr  Leu Asn Lys Lys Asp  Lys Glu Val Gln Gln  Leu Gln Glu 
    2165                 2170                 2175             


Asn Leu  Asp Ser Thr Val Thr  Gln Leu Ala Ala Phe  Thr Lys Ser 
    2180                 2185                 2190             


Met Ser  Ser Leu Gln Asp Asp  Arg Asp Arg Val Ile  Asp Glu Ala 
    2195                 2200                 2205             


Lys Lys  Trp Glu Arg Lys Phe  Ser Asp Ala Ile Gln  Ser Lys Glu 
    2210                 2215                 2220             


Glu Glu  Ile Arg Leu Lys Glu  Asp Asn Cys Ser Val  Leu Lys Asp 
    2225                 2230                 2235             


Gln Leu  Arg Gln Met Ser Ile  His Met Glu Glu Leu  Lys Ile Asn 
    2240                 2245                 2250             


Ile Ser  Arg Leu Glu His Asp  Lys Gln Ile Trp Glu  Ser Lys Ala 
    2255                 2260                 2265             


Gln Thr  Glu Val Gln Leu Gln  Gln Lys Val Cys Asp  Thr Leu Gln 
    2270                 2275                 2280             


Gly Glu  Asn Lys Glu Leu Leu  Ser Gln Leu Glu Glu  Thr Arg His 
    2285                 2290                 2295             


Leu Tyr  His Ser Ser Gln Asn  Glu Leu Ala Lys Leu  Glu Ser Glu 
    2300                 2305                 2310             


Leu Lys  Ser Leu Lys Asp Gln  Leu Thr Asp Leu Ser  Asn Ser Leu 
    2315                 2320                 2325             


Glu Lys  Cys Lys Glu Gln Lys  Gly Asn Leu Glu Gly  Ile Ile Arg 
    2330                 2335                 2340             


Gln Gln  Glu Ala Asp Ile Gln  Asn Ser Lys Phe Ser  Tyr Glu Gln 
    2345                 2350                 2355             


Leu Glu  Thr Asp Leu Gln Ala  Ser Arg Glu Leu Thr  Ser Arg Leu 
    2360                 2365                 2370             


His Glu  Glu Ile Asn Met Lys  Glu Gln Lys Ile Ile  Ser Leu Leu 
    2375                 2380                 2385             


Ser Gly  Lys Glu Glu Ala Ile  Gln Val Ala Ile Ala  Glu Leu Arg 
    2390                 2395                 2400             


Gln Gln  His Asp Lys Glu Ile  Lys Glu Leu Glu Asn  Leu Leu Ser 
    2405                 2410                 2415             


Gln Glu  Glu Glu Glu Asn Ile  Val Leu Glu Glu Glu  Asn Lys Lys 
    2420                 2425                 2430             


Ala Val  Asp Lys Thr Asn Gln  Leu Met Glu Thr Leu  Lys Thr Ile 
    2435                 2440                 2445             


Lys Lys  Glu Asn Ile Gln Gln  Lys Ala Gln Leu Asp  Ser Phe Val 
    2450                 2455                 2460             


Lys Ser  Met Ser Ser Leu Gln  Asn Asp Arg Asp Arg  Ile Val Gly 
    2465                 2470                 2475             


Asp Tyr  Gln Gln Leu Glu Glu  Arg His Leu Ser Ile  Ile Leu Glu 
    2480                 2485                 2490             


Lys Asp  Gln Leu Ile Gln Glu  Ala Ala Ala Glu Asn  Asn Lys Leu 
    2495                 2500                 2505             


Lys Glu  Glu Ile Arg Gly Leu  Arg Ser His Met Asp  Asp Leu Asn 
    2510                 2515                 2520             


Ser Glu  Asn Ala Lys Leu Asp  Ala Glu Leu Ile Gln  Tyr Arg Glu 
    2525                 2530                 2535             


Asp Leu  Asn Gln Val Ile Thr  Ile Lys Asp Ser Gln  Gln Lys Gln 
    2540                 2545                 2550             


Leu Leu  Glu Val Gln Leu Gln  Gln Asn Lys Glu Leu  Glu Asn Lys 
    2555                 2560                 2565             


Tyr Ala  Lys Leu Glu Glu Lys  Leu Lys Glu Ser Glu  Glu Ala Asn 
    2570                 2575                 2580             


Glu Asp  Leu Arg Arg Ser Phe  Asn Ala Leu Gln Glu  Glu Lys Gln 
    2585                 2590                 2595             


Asp Leu  Ser Lys Glu Ile Glu  Ser Leu Lys Val Ser  Ile Ser Gln 
    2600                 2605                 2610             


Leu Thr  Arg Gln Val Thr Ala  Leu Gln Glu Glu Gly  Thr Leu Gly 
    2615                 2620                 2625             


Leu Tyr  His Ala Gln Leu Lys  Val Lys Glu Glu Glu  Val His Arg 
    2630                 2635                 2640             


Leu Ser  Ala Leu Phe Ser Ser  Ser Gln Lys Arg Ile  Ala Glu Leu 
    2645                 2650                 2655             


Glu Glu  Glu Leu Val Cys Val  Gln Lys Glu Ala Ala  Lys Lys Val 
    2660                 2665                 2670             


Gly Glu  Ile Glu Asp Lys Leu  Lys Lys Glu Leu Lys  His Leu His 
    2675                 2680                 2685             


His Asp  Ala Gly Ile Met Arg  Asn Glu Thr Glu Thr  Ala Glu Glu 
    2690                 2695                 2700             


Arg Val  Ala Glu Leu Ala Arg  Asp Leu Val Glu Met  Glu Gln Lys 
    2705                 2710                 2715             


Leu Leu  Met Val Thr Lys Glu  Asn Lys Gly Leu Thr  Ala Gln Ile 
    2720                 2725                 2730             


Gln Ser  Phe Gly Arg Ser Met  Ser Ser Leu Gln Asn  Ser Arg Asp 
    2735                 2740                 2745             


His Ala  Asn Glu Glu Leu Asp  Glu Leu Lys Arg Lys  Tyr Asp Ala 
    2750                 2755                 2760             


Ser Leu  Lys Glu Leu Ala Gln  Leu Lys Glu Gln Gly  Leu Leu Asn 
    2765                 2770                 2775             


Arg Glu  Arg Asp Ala Leu Leu  Ser Glu Thr Ala Phe  Ser Met Asn 
    2780                 2785                 2790             


Ser Thr  Glu Glu Asn Ser Leu  Ser His Leu Glu Lys  Leu Asn Gln 
    2795                 2800                 2805             


Gln Leu  Leu Ser Lys Asp Glu  Gln Leu Leu His Leu  Ser Ser Gln 
    2810                 2815                 2820             


Leu Glu  Asp Ser Tyr Asn Gln  Val Gln Ser Phe Ser  Lys Ala Met 
    2825                 2830                 2835             


Ala Ser  Leu Gln Asn Glu Arg  Asp His Leu Trp Asn  Glu Leu Glu 
    2840                 2845                 2850             


Lys Phe  Arg Lys Ser Glu Glu  Gly Lys Gln Arg Ser  Ala Ala Gln 
    2855                 2860                 2865             


Pro Ser  Thr Ser Pro Ala Glu  Val Gln Ser Leu Lys  Lys Ala Met 
    2870                 2875                 2880             


Ser Ser  Leu Gln Asn Asp Arg  Asp Arg Leu Leu Lys  Glu Leu Lys 
    2885                 2890                 2895             


Asn Leu  Gln Gln Gln Tyr Leu  Gln Ile Asn Gln Glu  Ile Thr Glu 
    2900                 2905                 2910             


Leu His  Pro Leu Lys Ala Gln  Leu Gln Glu Tyr Gln  Asp Lys Thr 
    2915                 2920                 2925             


Lys Ala  Phe Gln Ile Met Gln  Glu Glu Leu Arg Gln  Glu Asn Leu 
    2930                 2935                 2940             


Ser Trp  Gln His Glu Leu His  Gln Leu Arg Met Glu  Lys Ser Ser 
    2945                 2950                 2955             


Trp Glu  Ile His Glu Arg Arg  Met Lys Glu Gln Tyr  Leu Met Ala 
    2960                 2965                 2970             


Ile Ser  Asp Lys Asp Gln Gln  Leu Ser His Leu Gln  Asn Leu Ile 
    2975                 2980                 2985             


Arg Glu  Leu Arg Ser Ser Ser  Ser Gln Thr Gln Pro  Leu Lys Val 
    2990                 2995                 3000             


Gln Tyr  Gln Arg Gln Ala Ser  Pro Glu Thr Ser Ala  Ser Pro Asp 
    3005                 3010                 3015             


Gly Ser  Gln Asn Leu Val Tyr  Glu Thr Glu Leu Leu  Arg Thr Gln 
    3020                 3025                 3030             


Leu Asn  Asp Ser Leu Lys Glu  Ile His Gln Lys Glu  Leu Arg Ile 
    3035                 3040                 3045             


Gln Gln  Leu Asn Ser Asn Phe  Ser Gln Leu Leu Glu  Glu Lys Asn 
    3050                 3055                 3060             


Thr Leu  Ser Ile Gln Leu Cys  Asp Thr Ser Gln Ser  Leu Arg Glu 
    3065                 3070                 3075             


Asn Gln  Gln His Tyr Gly Asp  Leu Leu Asn His Cys  Ala Val Leu 
    3080                 3085                 3090             


Glu Lys  Gln Val Gln Glu Leu  Gln Ala Gly Pro Leu  Asn Ile Asp 
    3095                 3100                 3105             


Val Ala  Pro Gly Ala Pro Gln  Glu Lys Asn Gly Val  His Arg Lys 
    3110                 3115                 3120             


Ser Asp  Pro Glu Glu Leu Arg  Glu Pro Gln Gln Ser  Phe Ser Glu 
    3125                 3130                 3135             


Ala Gln  Gln Gln Leu Cys Asn  Thr Arg Gln Glu Val  Asn Glu Leu 
    3140                 3145                 3150             


Arg Lys  Leu Leu Glu Glu Glu  Arg Asp Gln Arg Val  Ala Ala Glu 
    3155                 3160                 3165             


Asn Ala  Leu Ser Val Ala Glu  Glu Gln Ile Arg Arg  Leu Glu His 
    3170                 3175                 3180             


Ser Glu  Trp Asp Ser Ser Arg  Thr Pro Ile Ile Gly  Ser Cys Gly 
    3185                 3190                 3195             


Thr Gln  Glu Gln Ala Leu Leu  Ile Asp Leu Thr Ser  Asn Ser Cys 
    3200                 3205                 3210             


Arg Arg  Thr Arg Ser Gly Val  Gly Trp Lys Arg Val  Leu Arg Ser 
    3215                 3220                 3225             


Leu Cys  His Ser Arg Thr Arg  Val Pro Leu Leu Ala  Ala Ile Tyr 
    3230                 3235                 3240             


Phe Leu  Met Ile His Val Leu  Leu Ile Leu Cys Phe  Thr Gly His 
    3245                 3250                 3255             


Leu 
    


<210>  3064
<211>  560
<212>  PRT
<213>  Homo sapiens

<400>  3064

Met Leu Arg Gly Thr Leu Leu Cys Ala Val Leu Gly Leu Leu Arg Ala 
1               5                   10                  15      


Gln Pro Phe Pro Cys Pro Pro Ala Cys Lys Cys Val Phe Arg Asp Ala 
            20                  25                  30          


Ala Gln Cys Ser Gly Gly Asp Val Ala Arg Ile Ser Ala Leu Gly Leu 
        35                  40                  45              


Pro Thr Asn Leu Thr His Ile Leu Leu Phe Gly Met Gly Arg Gly Val 
    50                  55                  60                  


Leu Gln Ser Gln Ser Phe Ser Gly Met Thr Val Leu Gln Arg Leu Met 
65                  70                  75                  80  


Ile Ser Asp Ser His Ile Ser Ala Val Ala Pro Gly Thr Phe Ser Asp 
                85                  90                  95      


Leu Ile Lys Leu Lys Thr Leu Arg Leu Ser Arg Asn Lys Ile Thr His 
            100                 105                 110         


Leu Pro Gly Ala Leu Leu Asp Lys Met Val Leu Leu Glu Gln Leu Phe 
        115                 120                 125             


Leu Asp His Asn Ala Leu Arg Gly Ile Asp Gln Asn Met Phe Gln Lys 
    130                 135                 140                 


Leu Val Asn Leu Gln Glu Leu Ala Leu Asn Gln Asn Gln Leu Asp Phe 
145                 150                 155                 160 


Leu Pro Ala Ser Leu Phe Thr Asn Leu Glu Asn Leu Lys Leu Leu Asp 
                165                 170                 175     


Leu Ser Gly Asn Asn Leu Thr His Leu Pro Lys Gly Leu Leu Gly Ala 
            180                 185                 190         


Gln Ala Lys Leu Glu Arg Leu Leu Leu His Ser Asn Arg Leu Val Ser 
        195                 200                 205             


Leu Asp Ser Gly Leu Leu Asn Ser Leu Gly Ala Leu Thr Glu Leu Gln 
    210                 215                 220                 


Phe His Arg Asn His Ile Arg Ser Ile Ala Pro Gly Ala Phe Asp Arg 
225                 230                 235                 240 


Leu Pro Asn Leu Ser Ser Leu Thr Leu Ser Arg Asn His Leu Ala Phe 
                245                 250                 255     


Leu Pro Ser Ala Leu Phe Leu His Ser His Asn Leu Thr Leu Leu Thr 
            260                 265                 270         


Leu Phe Glu Asn Pro Leu Ala Glu Leu Pro Gly Val Leu Phe Gly Glu 
        275                 280                 285             


Met Gly Gly Leu Gln Glu Leu Trp Leu Asn Arg Thr Gln Leu Arg Thr 
    290                 295                 300                 


Leu Pro Ala Ala Ala Phe Arg Asn Leu Ser Arg Leu Arg Tyr Leu Gly 
305                 310                 315                 320 


Val Thr Leu Ser Pro Arg Leu Ser Ala Leu Pro Gln Gly Ala Phe Gln 
                325                 330                 335     


Gly Leu Gly Glu Leu Gln Val Leu Ala Leu His Ser Asn Gly Leu Thr 
            340                 345                 350         


Ala Leu Pro Asp Gly Leu Leu Arg Gly Leu Gly Lys Leu Arg Gln Val 
        355                 360                 365             


Ser Leu Arg Arg Asn Arg Leu Arg Ala Leu Pro Arg Ala Leu Phe Arg 
    370                 375                 380                 


Asn Leu Ser Ser Leu Glu Ser Val Gln Leu Asp His Asn Gln Leu Glu 
385                 390                 395                 400 


Thr Leu Pro Gly Asp Val Phe Gly Ala Leu Pro Arg Leu Thr Glu Val 
                405                 410                 415     


Leu Leu Gly His Asn Ser Trp Arg Cys Asp Cys Gly Leu Gly Pro Phe 
            420                 425                 430         


Leu Gly Trp Leu Arg Gln His Leu Gly Leu Val Gly Gly Glu Glu Pro 
        435                 440                 445             


Pro Arg Cys Ala Gly Pro Gly Ala His Ala Gly Leu Pro Leu Trp Ala 
    450                 455                 460                 


Leu Pro Gly Gly Asp Ala Glu Cys Pro Gly Pro Arg Gly Pro Pro Pro 
465                 470                 475                 480 


Arg Pro Ala Ala Asp Ser Ser Ser Glu Ala Pro Val His Pro Ala Leu 
                485                 490                 495     


Ala Pro Asn Ser Ser Glu Pro Trp Val Trp Ala Gln Pro Val Thr Thr 
            500                 505                 510         


Gly Lys Gly Gln Asp His Ser Pro Phe Trp Gly Phe Tyr Phe Leu Leu 
        515                 520                 525             


Leu Ala Val Gln Ala Met Ile Thr Val Ile Ile Val Phe Ala Met Ile 
    530                 535                 540                 


Lys Ile Gly Gln Leu Phe Arg Lys Leu Ile Arg Glu Arg Ala Leu Gly 
545                 550                 555                 560 


<210>  3065
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  3065

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys 
    210     


<210>  3066
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  3066

Met Ser Ser Ser Cys Ser Gly Leu Ser Arg Val Leu Val Ala Val Ala 
1               5                   10                  15      


Thr Ala Leu Val Ser Ala Ser Ser Pro Cys Pro Gln Ala Trp Gly Pro 
            20                  25                  30          


Pro Gly Val Gln Tyr Gly Gln Pro Gly Arg Ser Val Lys Leu Cys Cys 
        35                  40                  45              


Pro Gly Val Thr Ala Gly Asp Pro Val Ser Trp Phe Arg Asp Gly Glu 
    50                  55                  60                  


Pro Lys Leu Leu Gln Gly Pro Asp Ser Gly Leu Gly His Glu Leu Val 
65                  70                  75                  80  


Leu Ala Gln Ala Asp Ser Thr Asp Glu Gly Thr Tyr Ile Cys Gln Thr 
                85                  90                  95      


Leu Asp Gly Ala Leu Gly Gly Thr Val Thr Leu Gln Leu Gly Tyr Pro 
            100                 105                 110         


Pro Ala Arg Pro Val Val Ser Cys Gln Ala Ala Asp Tyr Glu Asn Phe 
        115                 120                 125             


Ser Cys Thr Trp Ser Pro Ser Gln Ile Ser Gly Leu Pro Thr Arg Tyr 
    130                 135                 140                 


Leu Thr Ser Tyr Arg Lys Lys Thr Val Leu Gly Ala Asp Ser Gln Arg 
145                 150                 155                 160 


Arg Ser Pro Ser Thr Gly Pro Trp Pro Cys Pro Gln Asp Pro Leu Gly 
                165                 170                 175     


Ala Ala Arg Cys Val Val His Gly Ala Glu Phe Trp Ser Gln Tyr Arg 
            180                 185                 190         


Ile Asn Val Thr Glu Val Asn Pro Leu Gly Ala Ser Thr Arg Leu Leu 
        195                 200                 205             


Asp Val Ser Leu Gln Ser Ile Leu Arg Pro Asp Pro Pro Gln Gly Leu 
    210                 215                 220                 


Arg Val Glu Ser Val Pro Gly Tyr Pro Arg Arg Leu Arg Ala Ser Trp 
225                 230                 235                 240 


Thr Tyr Pro Ala Ser Trp Pro Cys Gln Pro His Phe Leu Leu Lys Phe 
                245                 250                 255     


Arg Leu Gln Tyr Arg Pro Ala Gln His Pro Ala Trp Ser Thr Val Glu 
            260                 265                 270         


Pro Ala Gly Leu Glu Glu Val Ile Thr Asp Ala Val Ala Gly Leu Pro 
        275                 280                 285             


His Ala Val Arg Val Ser Ala Arg Asp Phe Leu Asp Ala Gly Thr Trp 
    290                 295                 300                 


Ser Thr Trp Ser Pro Glu Ala Trp Gly Thr Pro Ser Thr Gly Thr Ile 
305                 310                 315                 320 


Pro Lys Glu Ile Pro Ala Trp Gly Gln Leu His Thr Gln Pro Glu Val 
                325                 330                 335     


Glu Pro Gln Val Asp Ser Pro Ala Pro Pro Arg Pro Ser Leu Gln Pro 
            340                 345                 350         


His Pro Arg Leu Leu Asp His Arg Asp Ser Val Glu Gln Val Ala Val 
        355                 360                 365             


Leu Ala Ser Leu Gly Ile Leu Ser Phe Leu Gly Leu Val Ala Gly Ala 
    370                 375                 380                 


Leu Ala Leu Gly Leu Trp Leu Arg Leu Arg Arg Gly Gly Lys Asp Gly 
385                 390                 395                 400 


Ser Pro Lys Pro Gly Phe Leu Ala Ser Val Ile Pro Val Asp Arg Arg 
                405                 410                 415     


Pro Gly Ala Pro Asn Leu 
            420         


<210>  3067
<211>  844
<212>  PRT
<213>  Homo sapiens

<400>  3067

Met Val Gln Lys Ser Arg Asn Gly Gly Val Tyr Pro Gly Pro Ser Gly 
1               5                   10                  15      


Glu Lys Lys Leu Lys Val Gly Phe Val Gly Leu Asp Pro Gly Ala Pro 
            20                  25                  30          


Asp Ser Thr Arg Asp Gly Ala Leu Leu Ile Ala Gly Ser Glu Ala Pro 
        35                  40                  45              


Lys Arg Gly Ser Ile Leu Ser Lys Pro Arg Ala Gly Gly Ala Gly Ala 
    50                  55                  60                  


Gly Lys Pro Pro Lys Arg Asn Ala Phe Tyr Arg Lys Leu Gln Asn Phe 
65                  70                  75                  80  


Leu Tyr Asn Val Leu Glu Arg Pro Arg Gly Trp Ala Phe Ile Tyr His 
                85                  90                  95      


Ala Tyr Val Phe Leu Leu Val Phe Ser Cys Leu Val Leu Ser Val Phe 
            100                 105                 110         


Ser Thr Ile Lys Glu Tyr Glu Lys Ser Ser Glu Gly Ala Leu Tyr Ile 
        115                 120                 125             


Leu Glu Ile Val Thr Ile Val Val Phe Gly Val Glu Tyr Phe Val Arg 
    130                 135                 140                 


Ile Trp Ala Ala Gly Cys Cys Cys Arg Tyr Arg Gly Trp Arg Gly Arg 
145                 150                 155                 160 


Leu Lys Phe Ala Arg Lys Pro Phe Cys Val Ile Asp Ile Met Val Leu 
                165                 170                 175     


Ile Ala Ser Ile Ala Val Leu Ala Ala Gly Ser Gln Gly Asn Val Phe 
            180                 185                 190         


Ala Thr Ser Ala Leu Arg Ser Leu Arg Phe Leu Gln Ile Leu Arg Met 
        195                 200                 205             


Ile Arg Met Asp Arg Arg Gly Gly Thr Trp Lys Leu Leu Gly Ser Val 
    210                 215                 220                 


Val Tyr Ala His Ser Lys Glu Leu Val Thr Ala Trp Tyr Ile Gly Phe 
225                 230                 235                 240 


Leu Cys Leu Ile Leu Ala Ser Phe Leu Val Tyr Leu Ala Glu Lys Gly 
                245                 250                 255     


Glu Asn Asp His Phe Asp Thr Tyr Ala Asp Ala Leu Trp Trp Gly Leu 
            260                 265                 270         


Ile Thr Leu Thr Thr Ile Gly Tyr Gly Asp Lys Tyr Pro Gln Thr Trp 
        275                 280                 285             


Asn Gly Arg Leu Leu Ala Ala Thr Phe Thr Leu Ile Gly Val Ser Phe 
    290                 295                 300                 


Phe Ala Leu Pro Ala Gly Ile Leu Gly Ser Gly Phe Ala Leu Lys Val 
305                 310                 315                 320 


Gln Glu Gln His Arg Gln Lys His Phe Glu Lys Arg Arg Asn Pro Ala 
                325                 330                 335     


Ala Gly Leu Ile Gln Ser Ala Trp Arg Phe Tyr Ala Thr Asn Leu Ser 
            340                 345                 350         


Arg Thr Asp Leu His Ser Thr Trp Gln Tyr Tyr Glu Arg Thr Val Thr 
        355                 360                 365             


Val Pro Met Tyr Arg Leu Ile Pro Pro Leu Asn Gln Leu Glu Leu Leu 
    370                 375                 380                 


Arg Asn Leu Lys Ser Lys Ser Gly Leu Ala Phe Arg Lys Asp Pro Pro 
385                 390                 395                 400 


Pro Glu Pro Ser Pro Ser Gln Lys Val Ser Leu Lys Asp Arg Val Phe 
                405                 410                 415     


Ser Ser Pro Arg Gly Val Ala Ala Lys Gly Lys Gly Ser Pro Gln Ala 
            420                 425                 430         


Gln Thr Val Arg Arg Ser Pro Ser Ala Asp Gln Ser Leu Glu Asp Ser 
        435                 440                 445             


Pro Ser Lys Val Pro Lys Ser Trp Ser Phe Gly Asp Arg Ser Arg Ala 
    450                 455                 460                 


Arg Gln Ala Phe Arg Ile Lys Gly Ala Ala Ser Arg Gln Asn Ser Glu 
465                 470                 475                 480 


Glu Ala Ser Leu Pro Gly Glu Asp Ile Val Asp Asp Lys Ser Cys Pro 
                485                 490                 495     


Cys Glu Phe Val Thr Glu Asp Leu Thr Pro Gly Leu Lys Val Ser Ile 
            500                 505                 510         


Arg Ala Val Cys Val Met Arg Phe Leu Val Ser Lys Arg Lys Phe Lys 
        515                 520                 525             


Glu Ser Leu Arg Pro Tyr Asp Val Met Asp Val Ile Glu Gln Tyr Ser 
    530                 535                 540                 


Ala Gly His Leu Asp Met Leu Ser Arg Ile Lys Ser Leu Gln Ser Arg 
545                 550                 555                 560 


Val Asp Gln Ile Val Gly Arg Gly Pro Ala Ile Thr Asp Lys Asp Arg 
                565                 570                 575     


Thr Lys Gly Pro Ala Glu Ala Glu Leu Pro Glu Asp Pro Ser Met Met 
            580                 585                 590         


Gly Arg Leu Gly Lys Val Glu Lys Gln Val Leu Ser Met Glu Lys Lys 
        595                 600                 605             


Leu Asp Phe Leu Val Asn Ile Tyr Met Gln Arg Met Gly Ile Pro Pro 
    610                 615                 620                 


Thr Glu Thr Glu Ala Tyr Phe Gly Ala Lys Glu Pro Glu Pro Ala Pro 
625                 630                 635                 640 


Pro Tyr His Ser Pro Glu Asp Ser Arg Glu His Val Asp Arg His Gly 
                645                 650                 655     


Cys Ile Val Lys Ile Val Arg Ser Ser Ser Ser Thr Gly Gln Lys Asn 
            660                 665                 670         


Phe Ser Ala Pro Pro Ala Ala Pro Pro Val Gln Cys Pro Pro Ser Thr 
        675                 680                 685             


Ser Trp Gln Pro Gln Ser His Pro Arg Gln Gly His Gly Thr Ser Pro 
    690                 695                 700                 


Val Gly Asp His Gly Ser Leu Val Arg Ile Pro Pro Pro Pro Ala His 
705                 710                 715                 720 


Glu Arg Ser Leu Ser Ala Tyr Gly Gly Gly Asn Arg Ala Ser Met Glu 
                725                 730                 735     


Phe Leu Arg Gln Glu Asp Thr Pro Gly Cys Arg Pro Pro Glu Gly Asn 
            740                 745                 750         


Leu Arg Asp Ser Asp Thr Ser Ile Ser Ile Pro Ser Val Asp His Glu 
        755                 760                 765             


Glu Leu Glu Arg Ser Phe Ser Gly Phe Ser Ile Ser Gln Ser Lys Glu 
    770                 775                 780                 


Asn Leu Asp Ala Leu Asn Ser Cys Tyr Ala Ala Val Ala Pro Cys Ala 
785                 790                 795                 800 


Lys Val Arg Pro Tyr Ile Ala Glu Gly Glu Ser Asp Thr Asp Ser Asp 
                805                 810                 815     


Leu Cys Thr Pro Cys Gly Pro Pro Pro Arg Ser Ala Thr Gly Glu Gly 
            820                 825                 830         


Pro Phe Gly Asp Val Gly Trp Ala Gly Pro Arg Lys 
        835                 840                 


<210>  3068
<211>  872
<212>  PRT
<213>  Homo sapiens

<400>  3068

Met Gly Leu Lys Ala Arg Arg Ala Ala Gly Ala Ala Gly Gly Gly Gly 
1               5                   10                  15      


Asp Gly Gly Gly Gly Gly Gly Gly Ala Ala Asn Pro Ala Gly Gly Asp 
            20                  25                  30          


Ala Ala Ala Ala Gly Asp Glu Glu Arg Lys Val Gly Leu Ala Pro Gly 
        35                  40                  45              


Asp Val Glu Gln Val Thr Leu Ala Leu Gly Ala Gly Ala Asp Lys Asp 
    50                  55                  60                  


Gly Thr Leu Leu Leu Glu Gly Gly Gly Arg Asp Glu Gly Gln Arg Arg 
65                  70                  75                  80  


Thr Pro Gln Gly Ile Gly Leu Leu Ala Lys Thr Pro Leu Ser Arg Pro 
                85                  90                  95      


Val Lys Arg Asn Asn Ala Lys Tyr Arg Arg Ile Gln Thr Leu Ile Tyr 
            100                 105                 110         


Asp Ala Leu Glu Arg Pro Arg Gly Trp Ala Leu Leu Tyr His Ala Leu 
        115                 120                 125             


Val Phe Leu Ile Val Leu Gly Cys Leu Ile Leu Ala Val Leu Thr Thr 
    130                 135                 140                 


Phe Lys Glu Tyr Glu Thr Val Ser Gly Asp Trp Leu Leu Leu Leu Glu 
145                 150                 155                 160 


Thr Phe Ala Ile Phe Ile Phe Gly Ala Glu Phe Ala Leu Arg Ile Trp 
                165                 170                 175     


Ala Ala Gly Cys Cys Cys Arg Tyr Lys Gly Trp Arg Gly Arg Leu Lys 
            180                 185                 190         


Phe Ala Arg Lys Pro Leu Cys Met Leu Asp Ile Phe Val Leu Ile Ala 
        195                 200                 205             


Ser Val Pro Val Val Ala Val Gly Asn Gln Gly Asn Val Leu Ala Thr 
    210                 215                 220                 


Ser Leu Arg Ser Leu Arg Phe Leu Gln Ile Leu Arg Met Leu Arg Met 
225                 230                 235                 240 


Asp Arg Arg Gly Gly Thr Trp Lys Leu Leu Gly Ser Ala Ile Cys Ala 
                245                 250                 255     


His Ser Lys Glu Leu Ile Thr Ala Trp Tyr Ile Gly Phe Leu Thr Leu 
            260                 265                 270         


Ile Leu Ser Ser Phe Leu Val Tyr Leu Val Glu Lys Asp Val Pro Glu 
        275                 280                 285             


Val Asp Ala Gln Gly Glu Glu Met Lys Glu Glu Phe Glu Thr Tyr Ala 
    290                 295                 300                 


Asp Ala Leu Trp Trp Gly Leu Ile Thr Leu Ala Thr Ile Gly Tyr Gly 
305                 310                 315                 320 


Asp Lys Thr Pro Lys Thr Trp Glu Gly Arg Leu Ile Ala Ala Thr Phe 
                325                 330                 335     


Ser Leu Ile Gly Val Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu Gly 
            340                 345                 350         


Ser Gly Leu Ala Leu Lys Val Gln Glu Gln His Arg Gln Lys His Phe 
        355                 360                 365             


Glu Lys Arg Arg Lys Pro Ala Ala Glu Leu Ile Gln Ala Ala Trp Arg 
    370                 375                 380                 


Tyr Tyr Ala Thr Asn Pro Asn Arg Ile Asp Leu Val Ala Thr Trp Arg 
385                 390                 395                 400 


Phe Tyr Glu Ser Val Val Ser Phe Pro Phe Phe Arg Lys Glu Gln Leu 
                405                 410                 415     


Glu Ala Ala Ser Ser Gln Lys Leu Gly Leu Leu Asp Arg Val Arg Leu 
            420                 425                 430         


Ser Asn Pro Arg Gly Ser Asn Thr Lys Gly Lys Leu Phe Thr Pro Leu 
        435                 440                 445             


Asn Val Asp Ala Ile Glu Glu Ser Pro Ser Lys Glu Pro Lys Pro Val 
    450                 455                 460                 


Gly Leu Asn Asn Lys Glu Arg Phe Arg Thr Ala Phe Arg Met Lys Ala 
465                 470                 475                 480 


Tyr Ala Phe Trp Gln Ser Ser Glu Asp Ala Gly Thr Gly Asp Pro Met 
                485                 490                 495     


Ala Glu Asp Arg Gly Tyr Gly Asn Asp Phe Pro Ile Glu Asp Met Ile 
            500                 505                 510         


Pro Thr Leu Lys Ala Ala Ile Arg Ala Val Arg Ile Leu Gln Phe Arg 
        515                 520                 525             


Leu Tyr Lys Lys Lys Phe Lys Glu Thr Leu Arg Pro Tyr Asp Val Lys 
    530                 535                 540                 


Asp Val Ile Glu Gln Tyr Ser Ala Gly His Leu Asp Met Leu Ser Arg 
545                 550                 555                 560 


Ile Lys Tyr Leu Gln Thr Arg Ile Asp Met Ile Phe Thr Pro Gly Pro 
                565                 570                 575     


Pro Ser Thr Pro Lys His Lys Lys Ser Gln Lys Gly Ser Ala Phe Thr 
            580                 585                 590         


Phe Pro Ser Gln Gln Ser Pro Arg Asn Glu Pro Tyr Val Ala Arg Pro 
        595                 600                 605             


Ser Thr Ser Glu Ile Glu Asp Gln Ser Met Met Gly Lys Phe Val Lys 
    610                 615                 620                 


Val Glu Arg Gln Val Gln Asp Met Gly Lys Lys Leu Asp Phe Leu Val 
625                 630                 635                 640 


Asp Met His Met Gln His Met Glu Arg Leu Gln Val Gln Val Thr Glu 
                645                 650                 655     


Tyr Tyr Pro Thr Lys Gly Thr Ser Ser Pro Ala Glu Ala Glu Lys Lys 
            660                 665                 670         


Glu Asp Asn Arg Tyr Ser Asp Leu Lys Thr Ile Ile Cys Asn Tyr Ser 
        675                 680                 685             


Glu Thr Gly Pro Pro Glu Pro Pro Tyr Ser Phe His Gln Val Thr Ile 
    690                 695                 700                 


Asp Lys Val Ser Pro Tyr Gly Phe Phe Ala His Asp Pro Val Asn Leu 
705                 710                 715                 720 


Pro Arg Gly Gly Pro Ser Ser Gly Lys Val Gln Ala Thr Pro Pro Ser 
                725                 730                 735     


Ser Ala Thr Thr Tyr Val Glu Arg Pro Thr Val Leu Pro Ile Leu Thr 
            740                 745                 750         


Leu Leu Asp Ser Arg Val Ser Cys His Ser Gln Ala Asp Leu Gln Gly 
        755                 760                 765             


Pro Tyr Ser Asp Arg Ile Ser Pro Arg Gln Arg Arg Ser Ile Thr Arg 
    770                 775                 780                 


Asp Ser Asp Thr Pro Leu Ser Leu Met Ser Val Asn His Glu Glu Leu 
785                 790                 795                 800 


Glu Arg Ser Pro Ser Gly Phe Ser Ile Ser Gln Asp Arg Asp Asp Tyr 
                805                 810                 815     


Val Phe Gly Pro Asn Gly Gly Ser Ser Trp Met Arg Glu Lys Arg Tyr 
            820                 825                 830         


Leu Ala Glu Gly Glu Thr Asp Thr Asp Thr Asp Pro Phe Thr Pro Ser 
        835                 840                 845             


Gly Ser Met Pro Leu Ser Ser Thr Gly Asp Gly Ile Ser Asp Ser Val 
    850                 855                 860                 


Trp Thr Pro Ser Asn Lys Pro Ile 
865                 870         


<210>  3069
<211>  4655
<212>  PRT
<213>  Homo sapiens

<400>  3069

Met Asp Arg Gly Pro Ala Ala Val Ala Cys Thr Leu Leu Leu Ala Leu 
1               5                   10                  15      


Val Ala Cys Leu Ala Pro Ala Ser Gly Gln Glu Cys Asp Ser Ala His 
            20                  25                  30          


Phe Arg Cys Gly Ser Gly His Cys Ile Pro Ala Asp Trp Arg Cys Asp 
        35                  40                  45              


Gly Thr Lys Asp Cys Ser Asp Asp Ala Asp Glu Ile Gly Cys Ala Val 
    50                  55                  60                  


Val Thr Cys Gln Gln Gly Tyr Phe Lys Cys Gln Ser Glu Gly Gln Cys 
65                  70                  75                  80  


Ile Pro Asn Ser Trp Val Cys Asp Gln Asp Gln Asp Cys Asp Asp Gly 
                85                  90                  95      


Ser Asp Glu Arg Gln Asp Cys Ser Gln Ser Thr Cys Ser Ser His Gln 
            100                 105                 110         


Ile Thr Cys Ser Asn Gly Gln Cys Ile Pro Ser Glu Tyr Arg Cys Asp 
        115                 120                 125             


His Val Arg Asp Cys Pro Asp Gly Ala Asp Glu Asn Asp Cys Gln Tyr 
    130                 135                 140                 


Pro Thr Cys Glu Gln Leu Thr Cys Asp Asn Gly Ala Cys Tyr Asn Thr 
145                 150                 155                 160 


Ser Gln Lys Cys Asp Trp Lys Val Asp Cys Arg Asp Ser Ser Asp Glu 
                165                 170                 175     


Ile Asn Cys Thr Glu Ile Cys Leu His Asn Glu Phe Ser Cys Gly Asn 
            180                 185                 190         


Gly Glu Cys Ile Pro Arg Ala Tyr Val Cys Asp His Asp Asn Asp Cys 
        195                 200                 205             


Gln Asp Gly Ser Asp Glu His Ala Cys Asn Tyr Pro Thr Cys Gly Gly 
    210                 215                 220                 


Tyr Gln Phe Thr Cys Pro Ser Gly Arg Cys Ile Tyr Gln Asn Trp Val 
225                 230                 235                 240 


Cys Asp Gly Glu Asp Asp Cys Lys Asp Asn Gly Asp Glu Asp Gly Cys 
                245                 250                 255     


Glu Ser Gly Pro His Asp Val His Lys Cys Ser Pro Arg Glu Trp Ser 
            260                 265                 270         


Cys Pro Glu Ser Gly Arg Cys Ile Ser Ile Tyr Lys Val Cys Asp Gly 
        275                 280                 285             


Ile Leu Asp Cys Pro Gly Arg Glu Asp Glu Asn Asn Thr Ser Thr Gly 
    290                 295                 300                 


Lys Tyr Cys Ser Met Thr Leu Cys Ser Ala Leu Asn Cys Gln Tyr Gln 
305                 310                 315                 320 


Cys His Glu Thr Pro Tyr Gly Gly Ala Cys Phe Cys Pro Pro Gly Tyr 
                325                 330                 335     


Ile Ile Asn His Asn Asp Ser Arg Thr Cys Val Glu Phe Asp Asp Cys 
            340                 345                 350         


Gln Ile Trp Gly Ile Cys Asp Gln Lys Cys Glu Ser Arg Pro Gly Arg 
        355                 360                 365             


His Leu Cys His Cys Glu Glu Gly Tyr Ile Leu Glu Arg Gly Gln Tyr 
    370                 375                 380                 


Cys Lys Ala Asn Asp Ser Phe Gly Glu Ala Ser Ile Ile Phe Ser Asn 
385                 390                 395                 400 


Gly Arg Asp Leu Leu Ile Gly Asp Ile His Gly Arg Ser Phe Arg Ile 
                405                 410                 415     


Leu Val Glu Ser Gln Asn Arg Gly Val Ala Val Gly Val Ala Phe His 
            420                 425                 430         


Tyr His Leu Gln Arg Val Phe Trp Thr Asp Thr Val Gln Asn Lys Val 
        435                 440                 445             


Phe Ser Val Asp Ile Asn Gly Leu Asn Ile Gln Glu Val Leu Asn Val 
    450                 455                 460                 


Ser Val Glu Thr Pro Glu Asn Leu Ala Val Asp Trp Val Asn Asn Lys 
465                 470                 475                 480 


Ile Tyr Leu Val Glu Thr Lys Val Asn Arg Ile Asp Met Val Asn Leu 
                485                 490                 495     


Asp Gly Ser Tyr Arg Val Thr Leu Ile Thr Glu Asn Leu Gly His Pro 
            500                 505                 510         


Arg Gly Ile Ala Val Asp Pro Thr Val Gly Tyr Leu Phe Phe Ser Asp 
        515                 520                 525             


Trp Glu Ser Leu Ser Gly Glu Pro Lys Leu Glu Arg Ala Phe Met Asp 
    530                 535                 540                 


Gly Ser Asn Arg Lys Asp Leu Val Lys Thr Lys Leu Gly Trp Pro Ala 
545                 550                 555                 560 


Gly Val Thr Leu Asp Met Ile Ser Lys Arg Val Tyr Trp Val Asp Ser 
                565                 570                 575     


Arg Phe Asp Tyr Ile Glu Thr Val Thr Tyr Asp Gly Ile Gln Arg Lys 
            580                 585                 590         


Thr Val Val His Gly Gly Ser Leu Ile Pro His Pro Phe Gly Val Ser 
        595                 600                 605             


Leu Phe Glu Gly Gln Val Phe Phe Thr Asp Trp Thr Lys Met Ala Val 
    610                 615                 620                 


Leu Lys Ala Asn Lys Phe Thr Glu Thr Asn Pro Gln Val Tyr Tyr Gln 
625                 630                 635                 640 


Ala Ser Leu Arg Pro Tyr Gly Val Thr Val Tyr His Ser Leu Arg Gln 
                645                 650                 655     


Pro Tyr Ala Thr Asn Pro Cys Lys Asp Asn Asn Gly Gly Cys Glu Gln 
            660                 665                 670         


Val Cys Val Leu Ser His Arg Thr Asp Asn Asp Gly Leu Gly Phe Arg 
        675                 680                 685             


Cys Lys Cys Thr Phe Gly Phe Gln Leu Asp Thr Asp Glu Arg His Cys 
    690                 695                 700                 


Ile Ala Val Gln Asn Phe Leu Ile Phe Ser Ser Gln Val Ala Ile Arg 
705                 710                 715                 720 


Gly Ile Pro Phe Thr Leu Ser Thr Gln Glu Asp Val Met Val Pro Val 
                725                 730                 735     


Ser Gly Asn Pro Ser Phe Phe Val Gly Ile Asp Phe Asp Ala Gln Asp 
            740                 745                 750         


Ser Thr Ile Phe Phe Ser Asp Met Ser Lys His Met Ile Phe Lys Gln 
        755                 760                 765             


Lys Ile Asp Gly Thr Gly Arg Glu Ile Leu Ala Ala Asn Arg Val Glu 
    770                 775                 780                 


Asn Val Glu Ser Leu Ala Phe Asp Trp Ile Ser Lys Asn Leu Tyr Trp 
785                 790                 795                 800 


Thr Asp Ser His Tyr Lys Ser Ile Ser Val Met Arg Leu Ala Asp Lys 
                805                 810                 815     


Thr Arg Arg Thr Val Val Gln Tyr Leu Asn Asn Pro Arg Ser Val Val 
            820                 825                 830         


Val His Pro Phe Ala Gly Tyr Leu Phe Phe Thr Asp Trp Phe Arg Pro 
        835                 840                 845             


Ala Lys Ile Met Arg Ala Trp Ser Asp Gly Ser His Leu Leu Pro Val 
    850                 855                 860                 


Ile Asn Thr Thr Leu Gly Trp Pro Asn Gly Leu Ala Ile Asp Trp Ala 
865                 870                 875                 880 


Ala Ser Arg Leu Tyr Trp Val Asp Ala Tyr Phe Asp Lys Ile Glu His 
                885                 890                 895     


Ser Thr Phe Asp Gly Leu Asp Arg Arg Arg Leu Gly His Ile Glu Gln 
            900                 905                 910         


Met Thr His Pro Phe Gly Leu Ala Ile Phe Gly Glu His Leu Phe Phe 
        915                 920                 925             


Thr Asp Trp Arg Leu Gly Ala Ile Ile Arg Val Arg Lys Ala Asp Gly 
    930                 935                 940                 


Gly Glu Met Thr Val Ile Arg Ser Gly Ile Ala Tyr Ile Leu His Leu 
945                 950                 955                 960 


Lys Ser Tyr Asp Val Asn Ile Gln Thr Gly Ser Asn Ala Cys Asn Gln 
                965                 970                 975     


Pro Thr His Pro Asn Gly Asp Cys Ser His Phe Cys Phe Pro Val Pro 
            980                 985                 990         


Asn Phe Gln Arg Val Cys Gly Cys  Pro Tyr Gly Met Arg  Leu Ala Ser 
        995                 1000                 1005             


Asn His  Leu Thr Cys Glu Gly  Asp Pro Thr Asn Glu  Pro Pro Thr 
    1010                 1015                 1020             


Glu Gln  Cys Gly Leu Phe Ser  Phe Pro Cys Lys Asn  Gly Arg Cys 
    1025                 1030                 1035             


Val Pro  Asn Tyr Tyr Leu Cys  Asp Gly Val Asp Asp  Cys His Asp 
    1040                 1045                 1050             


Asn Ser  Asp Glu Gln Leu Cys  Gly Thr Leu Asn Asn  Thr Cys Ser 
    1055                 1060                 1065             


Ser Ser  Ala Phe Thr Cys Gly  His Gly Glu Cys Ile  Pro Ala His 
    1070                 1075                 1080             


Trp Arg  Cys Asp Lys Arg Asn  Asp Cys Val Asp Gly  Ser Asp Glu 
    1085                 1090                 1095             


His Asn  Cys Pro Thr His Ala  Pro Ala Ser Cys Leu  Asp Thr Gln 
    1100                 1105                 1110             


Tyr Thr  Cys Asp Asn His Gln  Cys Ile Ser Lys Asn  Trp Val Cys 
    1115                 1120                 1125             


Asp Thr  Asp Asn Asp Cys Gly  Asp Gly Ser Asp Glu  Lys Asn Cys 
    1130                 1135                 1140             


Asn Ser  Thr Glu Thr Cys Gln  Pro Ser Gln Phe Asn  Cys Pro Asn 
    1145                 1150                 1155             


His Arg  Cys Ile Asp Leu Ser  Phe Val Cys Asp Gly  Asp Lys Asp 
    1160                 1165                 1170             


Cys Val  Asp Gly Ser Asp Glu  Val Gly Cys Val Leu  Asn Cys Thr 
    1175                 1180                 1185             


Ala Ser  Gln Phe Lys Cys Ala  Ser Gly Asp Lys Cys  Ile Gly Val 
    1190                 1195                 1200             


Thr Asn  Arg Cys Asp Gly Val  Phe Asp Cys Ser Asp  Asn Ser Asp 
    1205                 1210                 1215             


Glu Ala  Gly Cys Pro Thr Arg  Pro Pro Gly Met Cys  His Ser Asp 
    1220                 1225                 1230             


Glu Phe  Gln Cys Gln Glu Asp  Gly Ile Cys Ile Pro  Asn Phe Trp 
    1235                 1240                 1245             


Glu Cys  Asp Gly His Pro Asp  Cys Leu Tyr Gly Ser  Asp Glu His 
    1250                 1255                 1260             


Asn Ala  Cys Val Pro Lys Thr  Cys Pro Ser Ser Tyr  Phe His Cys 
    1265                 1270                 1275             


Asp Asn  Gly Asn Cys Ile His  Arg Ala Trp Leu Cys  Asp Arg Asp 
    1280                 1285                 1290             


Asn Asp  Cys Gly Asp Met Ser  Asp Glu Lys Asp Cys  Pro Thr Gln 
    1295                 1300                 1305             


Pro Phe  Arg Cys Pro Ser Trp  Gln Trp Gln Cys Leu  Gly His Asn 
    1310                 1315                 1320             


Ile Cys  Val Asn Leu Ser Val  Val Cys Asp Gly Ile  Phe Asp Cys 
    1325                 1330                 1335             


Pro Asn  Gly Thr Asp Glu Ser  Pro Leu Cys Asn Gly  Asn Ser Cys 
    1340                 1345                 1350             


Ser Asp  Phe Asn Gly Gly Cys  Thr His Glu Cys Val  Gln Glu Pro 
    1355                 1360                 1365             


Phe Gly  Ala Lys Cys Leu Cys  Pro Leu Gly Phe Leu  Leu Ala Asn 
    1370                 1375                 1380             


Asp Ser  Lys Thr Cys Glu Asp  Ile Asp Glu Cys Asp  Ile Leu Gly 
    1385                 1390                 1395             


Ser Cys  Ser Gln His Cys Tyr  Asn Met Arg Gly Ser  Phe Arg Cys 
    1400                 1405                 1410             


Ser Cys  Asp Thr Gly Tyr Met  Leu Glu Ser Asp Gly  Arg Thr Cys 
    1415                 1420                 1425             


Lys Val  Thr Ala Ser Glu Ser  Leu Leu Leu Leu Val  Ala Ser Gln 
    1430                 1435                 1440             


Asn Lys  Ile Ile Ala Asp Ser  Val Thr Ser Gln Val  His Asn Ile 
    1445                 1450                 1455             


Tyr Ser  Leu Val Glu Asn Gly  Ser Tyr Ile Val Ala  Val Asp Phe 
    1460                 1465                 1470             


Asp Ser  Ile Ser Gly Arg Ile  Phe Trp Ser Asp Ala  Thr Gln Gly 
    1475                 1480                 1485             


Lys Thr  Trp Ser Ala Phe Gln  Asn Gly Thr Asp Arg  Arg Val Val 
    1490                 1495                 1500             


Phe Asp  Ser Ser Ile Ile Leu  Thr Glu Thr Ile Ala  Ile Asp Trp 
    1505                 1510                 1515             


Val Gly  Arg Asn Leu Tyr Trp  Thr Asp Tyr Ala Leu  Glu Thr Ile 
    1520                 1525                 1530             


Glu Val  Ser Lys Ile Asp Gly  Ser His Arg Thr Val  Leu Ile Ser 
    1535                 1540                 1545             


Lys Asn  Leu Thr Asn Pro Arg  Gly Leu Ala Leu Asp  Pro Arg Met 
    1550                 1555                 1560             


Asn Glu  His Leu Leu Phe Trp  Ser Asp Trp Gly His  His Pro Arg 
    1565                 1570                 1575             


Ile Glu  Arg Ala Ser Met Asp  Gly Ser Met Arg Thr  Val Ile Val 
    1580                 1585                 1590             


Gln Asp  Lys Ile Phe Trp Pro  Cys Gly Leu Thr Ile  Asp Tyr Pro 
    1595                 1600                 1605             


Asn Arg  Leu Leu Tyr Phe Met  Asp Ser Tyr Leu Asp  Tyr Met Asp 
    1610                 1615                 1620             


Phe Cys  Asp Tyr Asn Gly His  His Arg Arg Gln Val  Ile Ala Ser 
    1625                 1630                 1635             


Asp Leu  Ile Ile Arg His Pro  Tyr Ala Leu Thr Leu  Phe Glu Asp 
    1640                 1645                 1650             


Ser Val  Tyr Trp Thr Asp Arg  Ala Thr Arg Arg Val  Met Arg Ala 
    1655                 1660                 1665             


Asn Lys  Trp His Gly Gly Asn  Gln Ser Val Val Met  Tyr Asn Ile 
    1670                 1675                 1680             


Gln Trp  Pro Leu Gly Ile Val  Ala Val His Pro Ser  Lys Gln Pro 
    1685                 1690                 1695             


Asn Ser  Val Asn Pro Cys Ala  Phe Ser Arg Cys Ser  His Leu Cys 
    1700                 1705                 1710             


Leu Leu  Ser Ser Gln Gly Pro  His Phe Tyr Ser Cys  Val Cys Pro 
    1715                 1720                 1725             


Ser Gly  Trp Ser Leu Ser Pro  Asp Leu Leu Asn Cys  Leu Arg Asp 
    1730                 1735                 1740             


Asp Gln  Pro Phe Leu Ile Thr  Val Arg Gln His Ile  Ile Phe Gly 
    1745                 1750                 1755             


Ile Ser  Leu Asn Pro Glu Val  Lys Ser Asn Asp Ala  Met Val Pro 
    1760                 1765                 1770             


Ile Ala  Gly Ile Gln Asn Gly  Leu Asp Val Glu Phe  Asp Asp Ala 
    1775                 1780                 1785             


Glu Gln  Tyr Ile Tyr Trp Val  Glu Asn Pro Gly Glu  Ile His Arg 
    1790                 1795                 1800             


Val Lys  Thr Asp Gly Thr Asn  Arg Thr Val Phe Ala  Ser Ile Ser 
    1805                 1810                 1815             


Met Val  Gly Pro Ser Met Asn  Leu Ala Leu Asp Trp  Ile Ser Arg 
    1820                 1825                 1830             


Asn Leu  Tyr Ser Thr Asn Pro  Arg Thr Gln Ser Ile  Glu Val Leu 
    1835                 1840                 1845             


Thr Leu  His Gly Asp Ile Arg  Tyr Arg Lys Thr Leu  Ile Ala Asn 
    1850                 1855                 1860             


Asp Gly  Thr Ala Leu Gly Val  Gly Phe Pro Ile Gly  Ile Thr Val 
    1865                 1870                 1875             


Asp Pro  Ala Arg Gly Lys Leu  Tyr Trp Ser Asp Gln  Gly Thr Asp 
    1880                 1885                 1890             


Ser Gly  Val Pro Ala Lys Ile  Ala Ser Ala Asn Met  Asp Gly Thr 
    1895                 1900                 1905             


Ser Val  Lys Thr Leu Phe Thr  Gly Asn Leu Glu His  Leu Glu Cys 
    1910                 1915                 1920             


Val Thr  Leu Asp Ile Glu Glu  Gln Lys Leu Tyr Trp  Ala Val Thr 
    1925                 1930                 1935             


Gly Arg  Gly Val Ile Glu Arg  Gly Asn Val Asp Gly  Thr Asp Arg 
    1940                 1945                 1950             


Met Ile  Leu Val His Gln Leu  Ser His Pro Trp Gly  Ile Ala Val 
    1955                 1960                 1965             


His Asp  Ser Phe Leu Tyr Tyr  Thr Asp Glu Gln Tyr  Glu Val Ile 
    1970                 1975                 1980             


Glu Arg  Val Asp Lys Ala Thr  Gly Ala Asn Lys Ile  Val Leu Arg 
    1985                 1990                 1995             


Asp Asn  Val Pro Asn Leu Arg  Gly Leu Gln Val Tyr  His Arg Arg 
    2000                 2005                 2010             


Asn Ala  Ala Glu Ser Ser Asn  Gly Cys Ser Asn Asn  Met Asn Ala 
    2015                 2020                 2025             


Cys Gln  Gln Ile Cys Leu Pro  Val Pro Gly Gly Leu  Phe Ser Cys 
    2030                 2035                 2040             


Ala Cys  Ala Thr Gly Phe Lys  Leu Asn Pro Asp Asn  Arg Ser Cys 
    2045                 2050                 2055             


Ser Pro  Tyr Asn Ser Phe Ile  Val Val Ser Met Leu  Ser Ala Ile 
    2060                 2065                 2070             


Arg Gly  Phe Ser Leu Glu Leu  Ser Asp His Ser Glu  Thr Met Val 
    2075                 2080                 2085             


Pro Val  Ala Gly Gln Gly Arg  Asn Ala Leu His Val  Asp Val Asp 
    2090                 2095                 2100             


Val Ser  Ser Gly Phe Ile Tyr  Trp Cys Asp Phe Ser  Ser Ser Val 
    2105                 2110                 2115             


Ala Ser  Asp Asn Ala Ile Arg  Arg Ile Lys Pro Asp  Gly Ser Ser 
    2120                 2125                 2130             


Leu Met  Asn Ile Val Thr His  Gly Ile Gly Glu Asn  Gly Val Arg 
    2135                 2140                 2145             


Gly Ile  Ala Val Asp Trp Val  Ala Gly Asn Leu Tyr  Phe Thr Asn 
    2150                 2155                 2160             


Ala Phe  Val Ser Glu Thr Leu  Ile Glu Val Leu Arg  Ile Asn Thr 
    2165                 2170                 2175             


Thr Tyr  Arg Arg Val Leu Leu  Lys Val Thr Val Asp  Met Pro Arg 
    2180                 2185                 2190             


His Ile  Val Val Asp Pro Lys  Asn Arg Tyr Leu Phe  Trp Ala Asp 
    2195                 2200                 2205             


Tyr Gly  Gln Arg Pro Lys Ile  Glu Arg Ser Phe Leu  Asp Cys Thr 
    2210                 2215                 2220             


Asn Arg  Thr Val Leu Val Ser  Glu Gly Ile Val Thr  Pro Arg Gly 
    2225                 2230                 2235             


Leu Ala  Val Asp Arg Ser Asp  Gly Tyr Val Tyr Trp  Val Asp Asp 
    2240                 2245                 2250             


Ser Leu  Asp Ile Ile Ala Arg  Ile Arg Ile Asn Gly  Glu Asn Ser 
    2255                 2260                 2265             


Glu Val  Ile Arg Tyr Gly Ser  Arg Tyr Pro Thr Pro  Tyr Gly Ile 
    2270                 2275                 2280             


Thr Val  Phe Glu Asn Ser Ile  Ile Trp Val Asp Arg  Asn Leu Lys 
    2285                 2290                 2295             


Lys Ile  Phe Gln Ala Ser Lys  Glu Pro Glu Asn Thr  Glu Pro Pro 
    2300                 2305                 2310             


Thr Val  Ile Arg Asp Asn Ile  Asn Trp Leu Arg Asp  Val Thr Ile 
    2315                 2320                 2325             


Phe Asp  Lys Gln Val Gln Pro  Arg Ser Pro Ala Glu  Val Asn Asn 
    2330                 2335                 2340             


Asn Pro  Cys Leu Glu Asn Asn  Gly Gly Cys Ser His  Leu Cys Phe 
    2345                 2350                 2355             


Ala Leu  Pro Gly Leu His Thr  Pro Lys Cys Asp Cys  Ala Phe Gly 
    2360                 2365                 2370             


Thr Leu  Gln Ser Asp Gly Lys  Asn Cys Ala Ile Ser  Thr Glu Asn 
    2375                 2380                 2385             


Phe Leu  Ile Phe Ala Leu Ser  Asn Ser Leu Arg Ser  Leu His Leu 
    2390                 2395                 2400             


Asp Pro  Glu Asn His Ser Pro  Pro Phe Gln Thr Ile  Asn Val Glu 
    2405                 2410                 2415             


Arg Thr  Val Met Ser Leu Asp  Tyr Asp Ser Val Ser  Asp Arg Ile 
    2420                 2425                 2430             


Tyr Phe  Thr Gln Asn Leu Ala  Ser Gly Val Gly Gln  Ile Ser Tyr 
    2435                 2440                 2445             


Ala Thr  Leu Ser Ser Gly Ile  His Thr Pro Thr Val  Ile Ala Ser 
    2450                 2455                 2460             


Gly Ile  Gly Thr Ala Asp Gly  Ile Ala Phe Asp Trp  Ile Thr Arg 
    2465                 2470                 2475             


Arg Ile  Tyr Tyr Ser Asp Tyr  Leu Asn Gln Met Ile  Asn Ser Met 
    2480                 2485                 2490             


Ala Glu  Asp Gly Ser Asn Arg  Thr Val Ile Ala Arg  Val Pro Lys 
    2495                 2500                 2505             


Pro Arg  Ala Ile Val Leu Asp  Pro Cys Gln Gly Tyr  Leu Tyr Trp 
    2510                 2515                 2520             


Ala Asp  Trp Asp Thr His Ala  Lys Ile Glu Arg Ala  Thr Leu Gly 
    2525                 2530                 2535             


Gly Asn  Phe Arg Val Pro Ile  Val Asn Ser Ser Leu  Val Met Pro 
    2540                 2545                 2550             


Ser Gly  Leu Thr Leu Asp Tyr  Glu Glu Asp Leu Leu  Tyr Trp Val 
    2555                 2560                 2565             


Asp Ala  Ser Leu Gln Arg Ile  Glu Arg Ser Thr Leu  Thr Gly Val 
    2570                 2575                 2580             


Asp Arg  Glu Val Ile Val Asn  Ala Ala Val His Ala  Phe Gly Leu 
    2585                 2590                 2595             


Thr Leu  Tyr Gly Gln Tyr Ile  Tyr Trp Thr Asp Leu  Tyr Thr Gln 
    2600                 2605                 2610             


Arg Ile  Tyr Arg Ala Asn Lys  Tyr Asp Gly Ser Gly  Gln Ile Ala 
    2615                 2620                 2625             


Met Thr  Thr Asn Leu Leu Ser  Gln Pro Arg Gly Ile  Asn Thr Val 
    2630                 2635                 2640             


Val Lys  Asn Gln Lys Gln Gln  Cys Asn Asn Pro Cys  Glu Gln Phe 
    2645                 2650                 2655             


Asn Gly  Gly Cys Ser His Ile  Cys Ala Pro Gly Pro  Asn Gly Ala 
    2660                 2665                 2670             


Glu Cys  Gln Cys Pro His Glu  Gly Asn Trp Tyr Leu  Ala Asn Asn 
    2675                 2680                 2685             


Arg Lys  His Cys Ile Val Asp  Asn Gly Glu Arg Cys  Gly Ala Ser 
    2690                 2695                 2700             


Ser Phe  Thr Cys Ser Asn Gly  Arg Cys Ile Ser Glu  Glu Trp Lys 
    2705                 2710                 2715             


Cys Asp  Asn Asp Asn Asp Cys  Gly Asp Gly Ser Asp  Glu Met Glu 
    2720                 2725                 2730             


Ser Val  Cys Ala Leu His Thr  Cys Ser Pro Thr Ala  Phe Thr Cys 
    2735                 2740                 2745             


Ala Asn  Gly Arg Cys Val Gln  Tyr Ser Tyr Arg Cys  Asp Tyr Tyr 
    2750                 2755                 2760             


Asn Asp  Cys Gly Asp Gly Ser  Asp Glu Ala Gly Cys  Leu Phe Arg 
    2765                 2770                 2775             


Asp Cys  Asn Ala Thr Thr Glu  Phe Met Cys Asn Asn  Arg Arg Cys 
    2780                 2785                 2790             


Ile Pro  Arg Glu Phe Ile Cys  Asn Gly Val Asp Asn  Cys His Asp 
    2795                 2800                 2805             


Asn Asn  Thr Ser Asp Glu Lys  Asn Cys Pro Asp Arg  Thr Cys Gln 
    2810                 2815                 2820             


Ser Gly  Tyr Thr Lys Cys His  Asn Ser Asn Ile Cys  Ile Pro Arg 
    2825                 2830                 2835             


Val Tyr  Leu Cys Asp Gly Asp  Asn Asp Cys Gly Asp  Asn Ser Asp 
    2840                 2845                 2850             


Glu Asn  Pro Thr Tyr Cys Thr  Thr His Thr Cys Ser  Ser Ser Glu 
    2855                 2860                 2865             


Phe Gln  Cys Ala Ser Gly Arg  Cys Ile Pro Gln His  Trp Tyr Cys 
    2870                 2875                 2880             


Asp Gln  Glu Thr Asp Cys Phe  Asp Ala Ser Asp Glu  Pro Ala Ser 
    2885                 2890                 2895             


Cys Gly  His Ser Glu Arg Thr  Cys Leu Ala Asp Glu  Phe Lys Cys 
    2900                 2905                 2910             


Asp Gly  Gly Arg Cys Ile Pro  Ser Glu Trp Ile Cys  Asp Gly Asp 
    2915                 2920                 2925             


Asn Asp  Cys Gly Asp Met Ser  Asp Glu Asp Lys Arg  His Gln Cys 
    2930                 2935                 2940             


Gln Asn  Gln Asn Cys Ser Asp  Ser Glu Phe Leu Cys  Val Asn Asp 
    2945                 2950                 2955             


Arg Pro  Pro Asp Arg Arg Cys  Ile Pro Gln Ser Trp  Val Cys Asp 
    2960                 2965                 2970             


Gly Asp  Val Asp Cys Thr Asp  Gly Tyr Asp Glu Asn  Gln Asn Cys 
    2975                 2980                 2985             


Thr Arg  Arg Thr Cys Ser Glu  Asn Glu Phe Thr Cys  Gly Tyr Gly 
    2990                 2995                 3000             


Leu Cys  Ile Pro Lys Ile Phe  Arg Cys Asp Arg His  Asn Asp Cys 
    3005                 3010                 3015             


Gly Asp  Tyr Ser Asp Glu Arg  Gly Cys Leu Tyr Gln  Thr Cys Gln 
    3020                 3025                 3030             


Gln Asn  Gln Phe Thr Cys Gln  Asn Gly Arg Cys Ile  Ser Lys Thr 
    3035                 3040                 3045             


Phe Val  Cys Asp Glu Asp Asn  Asp Cys Gly Asp Gly  Ser Asp Glu 
    3050                 3055                 3060             


Leu Met  His Leu Cys His Thr  Pro Glu Pro Thr Cys  Pro Pro His 
    3065                 3070                 3075             


Glu Phe  Lys Cys Asp Asn Gly  Arg Cys Ile Glu Met  Met Lys Leu 
    3080                 3085                 3090             


Cys Asn  His Leu Asp Asp Cys  Leu Asp Asn Ser Asp  Glu Lys Gly 
    3095                 3100                 3105             


Cys Gly  Ile Asn Glu Cys His  Asp Pro Ser Ile Ser  Gly Cys Asp 
    3110                 3115                 3120             


His Asn  Cys Thr Asp Thr Leu  Thr Ser Phe Tyr Cys  Ser Cys Arg 
    3125                 3130                 3135             


Pro Gly  Tyr Lys Leu Met Ser  Asp Lys Arg Thr Cys  Val Asp Ile 
    3140                 3145                 3150             


Asp Glu  Cys Thr Glu Met Pro  Phe Val Cys Ser Gln  Lys Cys Glu 
    3155                 3160                 3165             


Asn Val  Ile Gly Ser Tyr Ile  Cys Lys Cys Ala Pro  Gly Tyr Leu 
    3170                 3175                 3180             


Arg Glu  Pro Asp Gly Lys Thr  Cys Arg Gln Asn Ser  Asn Ile Glu 
    3185                 3190                 3195             


Pro Tyr  Leu Ile Phe Ser Asn  Arg Tyr Tyr Leu Arg  Asn Leu Thr 
    3200                 3205                 3210             


Ile Asp  Gly Tyr Phe Tyr Ser  Leu Ile Leu Glu Gly  Leu Asp Asn 
    3215                 3220                 3225             


Val Val  Ala Leu Asp Phe Asp  Arg Val Glu Lys Arg  Leu Tyr Trp 
    3230                 3235                 3240             


Ile Asp  Thr Gln Arg Gln Val  Ile Glu Arg Met Phe  Leu Asn Lys 
    3245                 3250                 3255             


Thr Asn  Lys Glu Thr Ile Ile  Asn His Arg Leu Pro  Ala Ala Glu 
    3260                 3265                 3270             


Ser Leu  Ala Val Asp Trp Val  Ser Arg Lys Leu Tyr  Trp Leu Asp 
    3275                 3280                 3285             


Ala Arg  Leu Asp Gly Leu Phe  Val Ser Asp Leu Asn  Gly Gly His 
    3290                 3295                 3300             


Arg Arg  Met Leu Ala Gln His  Cys Val Asp Ala Asn  Asn Thr Phe 
    3305                 3310                 3315             


Cys Phe  Asp Asn Pro Arg Gly  Leu Ala Leu His Pro  Gln Tyr Gly 
    3320                 3325                 3330             


Tyr Leu  Tyr Trp Ala Asp Trp  Gly His Arg Ala Tyr  Ile Gly Arg 
    3335                 3340                 3345             


Val Gly  Met Asp Gly Thr Asn  Lys Ser Val Ile Ile  Ser Thr Lys 
    3350                 3355                 3360             


Leu Glu  Trp Pro Asn Gly Ile  Thr Ile Asp Tyr Thr  Asn Asp Leu 
    3365                 3370                 3375             


Leu Tyr  Trp Ala Asp Ala His  Leu Gly Tyr Ile Glu  Tyr Ser Asp 
    3380                 3385                 3390             


Leu Glu  Gly His His Arg His  Thr Val Tyr Asp Gly  Ala Leu Pro 
    3395                 3400                 3405             


His Pro  Phe Ala Ile Thr Ile  Phe Glu Asp Thr Ile  Tyr Trp Thr 
    3410                 3415                 3420             


Asp Trp  Asn Thr Arg Thr Val  Glu Lys Gly Asn Lys  Tyr Asp Gly 
    3425                 3430                 3435             


Ser Asn  Arg Gln Thr Leu Val  Asn Thr Thr His Arg  Pro Phe Asp 
    3440                 3445                 3450             


Ile His  Val Tyr His Pro Tyr  Arg Gln Pro Ile Val  Ser Asn Pro 
    3455                 3460                 3465             


Cys Gly  Thr Asn Asn Gly Gly  Cys Ser His Leu Cys  Leu Ile Lys 
    3470                 3475                 3480             


Pro Gly  Gly Lys Gly Phe Thr  Cys Glu Cys Pro Asp  Asp Phe Arg 
    3485                 3490                 3495             


Thr Leu  Gln Leu Ser Gly Ser  Thr Tyr Cys Met Pro  Met Cys Ser 
    3500                 3505                 3510             


Ser Thr  Gln Phe Leu Cys Ala  Asn Asn Glu Lys Cys  Ile Pro Ile 
    3515                 3520                 3525             


Trp Trp  Lys Cys Asp Gly Gln  Lys Asp Cys Ser Asp  Gly Ser Asp 
    3530                 3535                 3540             


Glu Leu  Ala Leu Cys Pro Gln  Arg Phe Cys Arg Leu  Gly Gln Phe 
    3545                 3550                 3555             


Gln Cys  Ser Asp Gly Asn Cys  Thr Ser Pro Gln Thr  Leu Cys Asn 
    3560                 3565                 3570             


Ala His  Gln Asn Cys Pro Asp  Gly Ser Asp Glu Asp  Arg Leu Leu 
    3575                 3580                 3585             


Cys Glu  Asn His His Cys Asp  Ser Asn Glu Trp Gln  Cys Ala Asn 
    3590                 3595                 3600             


Lys Arg  Cys Ile Pro Glu Ser  Trp Gln Cys Asp Thr  Phe Asn Asp 
    3605                 3610                 3615             


Cys Glu  Asp Asn Ser Asp Glu  Asp Ser Ser His Cys  Ala Ser Arg 
    3620                 3625                 3630             


Thr Cys  Arg Pro Gly Gln Phe  Arg Cys Ala Asn Gly  Arg Cys Ile 
    3635                 3640                 3645             


Pro Gln  Ala Trp Lys Cys Asp  Val Asp Asn Asp Cys  Gly Asp His 
    3650                 3655                 3660             


Ser Asp  Glu Pro Ile Glu Glu  Cys Met Ser Ser Ala  His Leu Cys 
    3665                 3670                 3675             


Asp Asn  Phe Thr Glu Phe Ser  Cys Lys Thr Asn Tyr  Arg Cys Ile 
    3680                 3685                 3690             


Pro Lys  Trp Ala Val Cys Asn  Gly Val Asp Asp Cys  Arg Asp Asn 
    3695                 3700                 3705             


Ser Asp  Glu Gln Gly Cys Glu  Glu Arg Thr Cys His  Pro Val Gly 
    3710                 3715                 3720             


Asp Phe  Arg Cys Lys Asn His  His Cys Ile Pro Leu  Arg Trp Gln 
    3725                 3730                 3735             


Cys Asp  Gly Gln Asn Asp Cys  Gly Asp Asn Ser Asp  Glu Glu Asn 
    3740                 3745                 3750             


Cys Ala  Pro Arg Glu Cys Thr  Glu Ser Glu Phe Arg  Cys Val Asn 
    3755                 3760                 3765             


Gln Gln  Cys Ile Pro Ser Arg  Trp Ile Cys Asp His  Tyr Asn Asp 
    3770                 3775                 3780             


Cys Gly  Asp Asn Ser Asp Glu  Arg Asp Cys Glu Met  Arg Thr Cys 
    3785                 3790                 3795             


His Pro  Glu Tyr Phe Gln Cys  Thr Ser Gly His Cys  Val His Ser 
    3800                 3805                 3810             


Glu Leu  Lys Cys Asp Gly Ser  Ala Asp Cys Leu Asp  Ala Ser Asp 
    3815                 3820                 3825             


Glu Ala  Asp Cys Pro Thr Arg  Phe Pro Asp Gly Ala  Tyr Cys Gln 
    3830                 3835                 3840             


Ala Thr  Met Phe Glu Cys Lys  Asn His Val Cys Ile  Pro Pro Tyr 
    3845                 3850                 3855             


Trp Lys  Cys Asp Gly Asp Asp  Asp Cys Gly Asp Gly  Ser Asp Glu 
    3860                 3865                 3870             


Glu Leu  His Leu Cys Leu Asp  Val Pro Cys Asn Ser  Pro Asn Arg 
    3875                 3880                 3885             


Phe Arg  Cys Asp Asn Asn Arg  Cys Ile Tyr Ser His  Glu Val Cys 
    3890                 3895                 3900             


Asn Gly  Val Asp Asp Cys Gly  Asp Gly Thr Asp Glu  Thr Glu Glu 
    3905                 3910                 3915             


His Cys  Arg Lys Pro Thr Pro  Lys Pro Cys Thr Glu  Tyr Glu Tyr 
    3920                 3925                 3930             


Lys Cys  Gly Asn Gly His Cys  Ile Pro His Asp Asn  Val Cys Asp 
    3935                 3940                 3945             


Asp Ala  Asp Asp Cys Gly Asp  Trp Ser Asp Glu Leu  Gly Cys Asn 
    3950                 3955                 3960             


Lys Gly  Lys Glu Arg Thr Cys  Ala Glu Asn Ile Cys  Glu Gln Asn 
    3965                 3970                 3975             


Cys Thr  Gln Leu Asn Glu Gly  Gly Phe Ile Cys Ser  Cys Thr Ala 
    3980                 3985                 3990             


Gly Phe  Glu Thr Asn Val Phe  Asp Arg Thr Ser Cys  Leu Asp Ile 
    3995                 4000                 4005             


Asn Glu  Cys Glu Gln Phe Gly  Thr Cys Pro Gln His  Cys Arg Asn 
    4010                 4015                 4020             


Thr Lys  Gly Ser Tyr Glu Cys  Val Cys Ala Asp Gly  Phe Thr Ser 
    4025                 4030                 4035             


Met Ser  Asp Arg Pro Gly Lys  Arg Cys Ala Ala Glu  Gly Ser Ser 
    4040                 4045                 4050             


Pro Leu  Leu Leu Leu Pro Asp  Asn Val Arg Ile Arg  Lys Tyr Asn 
    4055                 4060                 4065             


Leu Ser  Ser Glu Arg Phe Ser  Glu Tyr Leu Gln Asp  Glu Glu Tyr 
    4070                 4075                 4080             


Ile Gln  Ala Val Asp Tyr Asp  Trp Asp Pro Lys Asp  Ile Gly Leu 
    4085                 4090                 4095             


Ser Val  Val Tyr Tyr Thr Val  Arg Gly Glu Gly Ser  Arg Phe Gly 
    4100                 4105                 4110             


Ala Ile  Lys Arg Ala Tyr Ile  Pro Asn Phe Glu Ser  Gly Arg Asn 
    4115                 4120                 4125             


Asn Leu  Val Gln Glu Val Asp  Leu Lys Leu Lys Tyr  Val Met Gln 
    4130                 4135                 4140             


Pro Asp  Gly Ile Ala Val Asp  Trp Val Gly Arg His  Ile Tyr Trp 
    4145                 4150                 4155             


Ser Asp  Val Lys Asn Lys Arg  Ile Glu Val Ala Lys  Leu Asp Gly 
    4160                 4165                 4170             


Arg Tyr  Arg Lys Trp Leu Ile  Ser Thr Asp Leu Asp  Gln Pro Ala 
    4175                 4180                 4185             


Ala Ile  Ala Val Asn Pro Lys  Leu Gly Leu Met Phe  Trp Thr Asp 
    4190                 4195                 4200             


Trp Gly  Lys Glu Pro Lys Ile  Glu Ser Ala Trp Met  Asn Gly Glu 
    4205                 4210                 4215             


Asp Arg  Asn Ile Leu Val Phe  Glu Asp Leu Gly Trp  Pro Thr Gly 
    4220                 4225                 4230             


Leu Ser  Ile Asp Tyr Leu Asn  Asn Asp Arg Ile Tyr  Trp Ser Asp 
    4235                 4240                 4245             


Phe Lys  Glu Asp Val Ile Glu  Thr Ile Lys Tyr Asp  Gly Thr Asp 
    4250                 4255                 4260             


Arg Arg  Val Ile Ala Lys Glu  Ala Met Asn Pro Tyr  Ser Leu Asp 
    4265                 4270                 4275             


Ile Phe  Glu Asp Gln Leu Tyr  Trp Ile Ser Lys Glu  Lys Gly Glu 
    4280                 4285                 4290             


Val Trp  Lys Gln Asn Lys Phe  Gly Gln Gly Lys Lys  Glu Lys Thr 
    4295                 4300                 4305             


Leu Val  Val Asn Pro Trp Leu  Thr Gln Val Arg Ile  Phe His Gln 
    4310                 4315                 4320             


Leu Arg  Tyr Asn Lys Ser Val  Pro Asn Leu Cys Lys  Gln Ile Cys 
    4325                 4330                 4335             


Ser His  Leu Cys Leu Leu Arg  Pro Gly Gly Tyr Ser  Cys Ala Cys 
    4340                 4345                 4350             


Pro Gln  Gly Ser Ser Phe Ile  Glu Gly Ser Thr Thr  Glu Cys Asp 
    4355                 4360                 4365             


Ala Ala  Ile Glu Leu Pro Ile  Asn Leu Pro Pro Pro  Cys Arg Cys 
    4370                 4375                 4380             


Met His  Gly Gly Asn Cys Tyr  Phe Asp Glu Thr Asp  Leu Pro Lys 
    4385                 4390                 4395             


Cys Lys  Cys Pro Ser Gly Tyr  Thr Gly Lys Tyr Cys  Glu Met Ala 
    4400                 4405                 4410             


Phe Ser  Lys Gly Ile Ser Pro  Gly Thr Thr Ala Val  Ala Val Leu 
    4415                 4420                 4425             


Leu Thr  Ile Leu Leu Ile Val  Val Ile Gly Ala Leu  Ala Ile Ala 
    4430                 4435                 4440             


Gly Phe  Phe His Tyr Arg Arg  Thr Gly Ser Leu Leu  Pro Ala Leu 
    4445                 4450                 4455             


Pro Lys  Leu Pro Ser Leu Ser  Ser Leu Val Lys Pro  Ser Glu Asn 
    4460                 4465                 4470             


Gly Asn  Gly Val Thr Phe Arg  Ser Gly Ala Asp Leu  Asn Met Asp 
    4475                 4480                 4485             


Ile Gly  Val Ser Gly Phe Gly  Pro Glu Thr Ala Ile  Asp Arg Ser 
    4490                 4495                 4500             


Met Ala  Met Ser Glu Asp Phe  Val Met Glu Met Gly  Lys Gln Pro 
    4505                 4510                 4515             


Ile Ile  Phe Glu Asn Pro Met  Tyr Ser Ala Arg Asp  Ser Ala Val 
    4520                 4525                 4530             


Lys Val  Val Gln Pro Ile Gln  Val Thr Val Ser Glu  Asn Val Asp 
    4535                 4540                 4545             


Asn Lys  Asn Tyr Gly Ser Pro  Ile Asn Pro Ser Glu  Ile Val Pro 
    4550                 4555                 4560             


Glu Thr  Asn Pro Thr Ser Pro  Ala Ala Asp Gly Thr  Gln Val Thr 
    4565                 4570                 4575             


Lys Trp  Asn Leu Phe Lys Arg  Lys Ser Lys Gln Thr  Thr Asn Phe 
    4580                 4585                 4590             


Glu Asn  Pro Ile Tyr Ala Gln  Met Glu Asn Glu Gln  Lys Glu Ser 
    4595                 4600                 4605             


Val Ala  Ala Thr Pro Pro Pro  Ser Pro Ser Leu Pro  Ala Lys Pro 
    4610                 4615                 4620             


Lys Pro  Pro Ser Arg Arg Asp  Pro Thr Pro Thr Tyr  Ser Ala Thr 
    4625                 4630                 4635             


Glu Asp  Thr Phe Lys Asp Thr  Ala Asn Leu Val Lys  Glu Asp Ser 
    4640                 4645                 4650             


Glu Val  
    4655 


<210>  3070
<211>  1176
<212>  PRT
<213>  Homo sapiens

<400>  3070

Met Lys Gly Ala Arg Trp Arg Arg Val Pro Trp Val Ser Leu Ser Cys 
1               5                   10                  15      


Leu Cys Leu Cys Leu Leu Pro His Val Val Pro Gly Met Thr Thr Pro 
            20                  25                  30          


Ser Leu Lys Thr Asp Gly Gly Arg Arg Thr Ala Thr Ser Pro Pro Pro 
        35                  40                  45              


Thr Thr Ser Gln Thr Ile Ile Ser Thr Ile Pro Ser Thr Ala Met His 
    50                  55                  60                  


Thr Arg Ser Thr Ala Ala Pro Ile Pro Ile Leu Pro Glu Arg Gly Val 
65                  70                  75                  80  


Ser Leu Phe Pro Tyr Gly Ala Gly Ala Gly Asp Leu Glu Phe Val Arg 
                85                  90                  95      


Arg Thr Val Asp Phe Thr Ser Pro Leu Phe Lys Pro Ala Thr Gly Phe 
            100                 105                 110         


Pro Leu Gly Ser Ser Leu Arg Asp Ser Leu Tyr Phe Thr Asp Asn Gly 
        115                 120                 125             


Gln Ile Ile Phe Pro Glu Ser Asp Tyr Gln Ile Phe Ser Tyr Pro Asn 
    130                 135                 140                 


Pro Leu Pro Thr Gly Phe Thr Gly Arg Asp Pro Val Ala Leu Val Ala 
145                 150                 155                 160 


Pro Phe Trp Asp Asp Ala Asp Phe Ser Thr Gly Arg Gly Thr Thr Phe 
                165                 170                 175     


Tyr Gln Glu Tyr Glu Thr Phe Tyr Gly Glu His Ser Leu Leu Val Gln 
            180                 185                 190         


Gln Ala Glu Ser Trp Ile Arg Lys Met Thr Asn Asn Gly Gly Tyr Lys 
        195                 200                 205             


Ala Arg Trp Ala Leu Lys Val Thr Trp Val Asn Ala His Ala Tyr Pro 
    210                 215                 220                 


Ala Gln Trp Thr Leu Gly Ser Asn Thr Tyr Gln Ala Ile Leu Ser Thr 
225                 230                 235                 240 


Asp Gly Ser Arg Ser Tyr Ala Leu Phe Leu Tyr Gln Ser Gly Gly Met 
                245                 250                 255     


Gln Trp Asp Val Ala Gln Arg Ser Gly Asn Pro Val Leu Met Gly Phe 
            260                 265                 270         


Ser Ser Gly Asp Gly Tyr Phe Glu Asn Ser Pro Leu Met Ser Gln Pro 
        275                 280                 285             


Val Trp Glu Arg Tyr Arg Pro Asp Arg Phe Leu Asn Ser Asn Ser Gly 
    290                 295                 300                 


Leu Gln Gly Leu Gln Phe Tyr Arg Leu His Arg Glu Glu Arg Pro Asn 
305                 310                 315                 320 


Tyr Arg Leu Glu Cys Leu Gln Trp Leu Lys Ser Gln Pro Arg Trp Pro 
                325                 330                 335     


Ser Trp Gly Trp Asn Gln Val Ser Cys Pro Cys Ser Trp Gln Gln Gly 
            340                 345                 350         


Arg Arg Asp Leu Arg Phe Gln Pro Val Ser Ile Gly Arg Trp Gly Leu 
        355                 360                 365             


Gly Ser Arg Gln Leu Cys Ser Phe Thr Ser Trp Arg Gly Gly Val Cys 
    370                 375                 380                 


Cys Ser Tyr Gly Pro Trp Gly Glu Phe Arg Glu Gly Trp His Val Gln 
385                 390                 395                 400 


Arg Pro Trp Gln Leu Ala Gln Glu Leu Glu Pro Gln Ser Trp Cys Cys 
                405                 410                 415     


Arg Trp Asn Asp Lys Pro Tyr Leu Cys Ala Leu Tyr Gln Gln Arg Arg 
            420                 425                 430         


Pro His Val Gly Cys Ala Thr Tyr Arg Pro Pro Gln Pro Ala Trp Met 
        435                 440                 445             


Phe Gly Asp Pro His Ile Thr Thr Leu Asp Gly Val Ser Tyr Thr Phe 
    450                 455                 460                 


Asn Gly Leu Gly Asp Phe Leu Leu Val Gly Ala Gln Asp Gly Asn Ser 
465                 470                 475                 480 


Ser Phe Leu Leu Gln Gly Arg Thr Ala Gln Thr Gly Ser Ala Gln Ala 
                485                 490                 495     


Thr Asn Phe Ile Ala Phe Ala Ala Gln Tyr Arg Ser Ser Ser Leu Gly 
            500                 505                 510         


Pro Val Thr Val Gln Trp Leu Leu Glu Pro His Asp Ala Ile Arg Val 
        515                 520                 525             


Leu Leu Asp Asn Gln Thr Val Thr Phe Gln Pro Asp His Glu Asp Gly 
    530                 535                 540                 


Gly Gly Gln Glu Thr Phe Asn Ala Thr Gly Val Leu Leu Ser Arg Asn 
545                 550                 555                 560 


Gly Ser Glu Val Ser Ala Ser Phe Asp Gly Trp Ala Thr Val Ser Val 
                565                 570                 575     


Ile Ala Leu Ser Asn Ile Leu His Ala Ser Ala Ser Leu Pro Pro Glu 
            580                 585                 590         


Tyr Gln Asn Arg Thr Glu Gly Leu Leu Gly Val Trp Asn Asn Asn Pro 
        595                 600                 605             


Glu Asp Asp Phe Arg Met Pro Asn Gly Ser Thr Ile Pro Pro Gly Ser 
    610                 615                 620                 


Pro Glu Glu Met Leu Phe His Phe Gly Met Thr Trp Gln Ile Asn Gly 
625                 630                 635                 640 


Thr Gly Leu Leu Gly Lys Arg Asn Asp Gln Leu Pro Ser Asn Phe Thr 
                645                 650                 655     


Pro Val Phe Tyr Ser Gln Leu Gln Lys Asn Ser Ser Trp Ala Glu His 
            660                 665                 670         


Leu Ile Ser Asn Cys Asp Gly Asp Ser Ser Cys Ile Tyr Asp Thr Leu 
        675                 680                 685             


Ala Leu Arg Asn Ala Ser Ile Gly Leu His Thr Arg Glu Val Ser Lys 
    690                 695                 700                 


Asn Tyr Glu Gln Ala Asn Ala Thr Leu Asn Gln Tyr Pro Pro Ser Ile 
705                 710                 715                 720 


Asn Gly Gly Arg Val Ile Glu Ala Tyr Lys Gly Gln Thr Thr Leu Ile 
                725                 730                 735     


Gln Tyr Thr Ser Asn Ala Glu Asp Ala Asn Phe Thr Leu Arg Asp Ser 
            740                 745                 750         


Cys Thr Asp Leu Glu Leu Phe Glu Asn Gly Thr Leu Leu Trp Thr Pro 
        755                 760                 765             


Lys Ser Leu Glu Pro Phe Thr Leu Glu Ile Leu Ala Arg Ser Ala Lys 
    770                 775                 780                 


Ile Gly Leu Ala Ser Ala Leu Gln Pro Arg Thr Val Val Cys His Cys 
785                 790                 795                 800 


Asn Ala Glu Ser Gln Cys Leu Tyr Asn Gln Thr Ser Arg Val Gly Asn 
                805                 810                 815     


Ser Ser Leu Glu Val Ala Gly Cys Lys Cys Asp Gly Gly Thr Phe Gly 
            820                 825                 830         


Arg Tyr Cys Glu Gly Ser Glu Asp Ala Cys Glu Glu Pro Cys Phe Pro 
        835                 840                 845             


Ser Val His Cys Val Pro Gly Lys Gly Cys Glu Ala Cys Pro Pro Asn 
    850                 855                 860                 


Leu Thr Gly Asp Gly Arg His Cys Ala Ala Leu Gly Ser Ser Phe Leu 
865                 870                 875                 880 


Cys Gln Asn Gln Ser Cys Pro Val Asn Tyr Cys Tyr Asn Gln Gly His 
                885                 890                 895     


Cys Tyr Ile Ser Gln Thr Leu Gly Cys Gln Pro Met Cys Thr Cys Pro 
            900                 905                 910         


Pro Ala Phe Thr Asp Ser Arg Cys Phe Leu Ala Gly Asn Asn Phe Ser 
        915                 920                 925             


Pro Thr Val Asn Leu Glu Leu Pro Leu Arg Val Ile Gln Leu Leu Leu 
    930                 935                 940                 


Ser Glu Glu Glu Asn Ala Ser Met Ala Glu Val Asn Ala Ser Val Ala 
945                 950                 955                 960 


Tyr Arg Leu Gly Thr Leu Asp Met Arg Ala Phe Leu Arg Asn Ser Gln 
                965                 970                 975     


Val Glu Arg Ile Asp Ser Ala Ala Pro Ala Ser Gly Ser Pro Ile Gln 
            980                 985                 990         


His Trp Met Val Ile Ser Glu Phe  Gln Tyr Arg Pro Arg  Gly Pro Val 
        995                 1000                 1005             


Ile Asp  Phe Leu Asn Asn Gln  Leu Leu Ala Ala Val  Val Glu Ala 
    1010                 1015                 1020             


Phe Leu  Tyr His Val Pro Arg  Arg Ser Glu Glu Pro  Arg Asn Asp 
    1025                 1030                 1035             


Val Val  Phe Gln Pro Ile Ser  Gly Glu Asp Val Arg  Asp Val Thr 
    1040                 1045                 1050             


Ala Leu  Asn Val Ser Thr Leu  Lys Ala Tyr Phe Arg  Cys Asp Gly 
    1055                 1060                 1065             


Tyr Lys  Gly Tyr Asp Leu Val  Tyr Ser Pro Gln Ser  Gly Phe Thr 
    1070                 1075                 1080             


Cys Val  Ser Pro Cys Ser Arg  Gly Tyr Cys Asp His  Gly Gly Gln 
    1085                 1090                 1095             


Cys Gln  His Leu Pro Ser Gly  Pro Arg Cys Ser Cys  Val Ser Phe 
    1100                 1105                 1110             


Ser Ile  Tyr Thr Ala Trp Gly  Glu His Cys Glu His  Leu Ser Met 
    1115                 1120                 1125             


Lys Leu  Asp Ala Phe Phe Gly  Ile Phe Phe Gly Ala  Leu Gly Gly 
    1130                 1135                 1140             


Leu Leu  Leu Leu Gly Val Gly  Thr Phe Val Val Leu  Arg Phe Trp 
    1145                 1150                 1155             


Gly Cys  Ser Gly Ala Arg Phe  Ser Tyr Phe Leu Asn  Ser Ala Glu 
    1160                 1165                 1170             


Ala Leu  Pro 
    1175     


<210>  3071
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  3071

Met Trp Phe Glu Ile Leu Pro Gly Leu Ser Val Met Gly Val Cys Leu 
1               5                   10                  15      


Leu Ile Pro Gly Leu Ala Thr Ala Tyr Ile His Arg Phe Thr Asn Gly 
            20                  25                  30          


Gly Lys Glu Lys Arg Val Ala His Phe Gly Tyr His Trp Ser Leu Met 
        35                  40                  45              


Glu Arg Asp Arg Arg Ile Ser Gly Val Asp Arg Tyr Tyr Val Ser Lys 
    50                  55                  60                  


Gly Leu Glu Asn Ile Asp 
65                  70  


<210>  3072
<211>  84
<212>  PRT
<213>  Homo sapiens

<400>  3072

Met Ala Ala Arg Val Gly Ala Phe Leu Lys Asn Ala Trp Asp Lys Glu 
1               5                   10                  15      


Pro Val Leu Val Val Ser Phe Val Val Gly Gly Leu Ala Val Ile Leu 
            20                  25                  30          


Pro Pro Leu Ser Pro Tyr Phe Lys Tyr Ser Val Met Ile Asn Lys Ala 
        35                  40                  45              


Thr Pro Tyr Asn Tyr Pro Val Pro Val Arg Asp Asp Gly Asn Met Pro 
    50                  55                  60                  


Asp Val Pro Ser His Pro Gln Asp Pro Gln Gly Pro Ser Leu Glu Trp 
65                  70                  75                  80  


Leu Lys Lys Leu 
                


<210>  3073
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  3073

Met Ile Cys Trp Arg His Pro Ser Ala Pro Cys Gly Arg Gly Glu Trp 
1               5                   10                  15      


Gln Val Pro Arg Ser Gln Leu Pro Leu Ala Arg Val Glu Phe Pro Val 
            20                  25                  30          


Ala Leu Gly Leu Gly Val Ala Val Gly Ala Glu Ala Ala Ala Ile Met 
        35                  40                  45              


Val Asn Leu Leu Gln Ile Val Arg Asp His Trp Val His Val Leu Val 
    50                  55                  60                  


Pro Met Gly Phe Val Ile Gly Cys Tyr Leu Asp Arg Lys Ser Asp Glu 
65                  70                  75                  80  


Arg Leu Thr Ala Phe Arg Asn Lys Ser Met Leu Phe Lys Arg Glu Leu 
                85                  90                  95      


Gln Pro Ser Glu Glu Val Thr Trp Lys 
            100                 105 


<210>  3074
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  3074

Met Ile Ala Arg Arg Asn Pro Glu Pro Leu Arg Phe Leu Pro Asp Glu 
1               5                   10                  15      


Ala Arg Ser Leu Pro Pro Pro Lys Leu Thr Asp Pro Arg Leu Leu Tyr 
            20                  25                  30          


Ile Gly Phe Leu Gly Tyr Cys Ser Gly Leu Ile Asp Asn Leu Ile Arg 
        35                  40                  45              


Arg Arg Pro Ile Ala Thr Ala Gly Leu His Arg Gln Leu Leu Tyr Ile 
    50                  55                  60                  


Thr Ala Phe Phe Phe Ala Gly Tyr Tyr Leu Val Lys Arg Glu Asp Tyr 
65                  70                  75                  80  


Leu Tyr Ala Val Arg Asp Arg Glu Met Phe Gly Tyr Met Lys Leu His 
                85                  90                  95      


Pro Glu Asp Phe Pro Glu Glu Asp Lys Lys Thr Tyr Gly Glu Ile Phe 
            100                 105                 110         


Glu Lys Phe His Pro Ile Arg 
        115                 


<210>  3075
<211>  2003
<212>  PRT
<213>  Homo sapiens

<400>  3075

Met Gln Pro Pro Ser Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Cys Val Ser Val Val Arg Pro Arg Gly Leu Leu Cys Gly Ser Phe Pro 
            20                  25                  30          


Glu Pro Cys Ala Asn Gly Gly Thr Cys Leu Ser Leu Ser Leu Gly Gln 
        35                  40                  45              


Gly Thr Cys Gln Cys Ala Pro Gly Phe Leu Gly Glu Thr Cys Gln Phe 
    50                  55                  60                  


Pro Asp Pro Cys Gln Asn Ala Gln Leu Cys Gln Asn Gly Gly Ser Cys 
65                  70                  75                  80  


Gln Ala Leu Leu Pro Ala Pro Leu Gly Leu Pro Ser Ser Pro Ser Pro 
                85                  90                  95      


Leu Thr Pro Ser Phe Leu Cys Thr Cys Leu Pro Gly Phe Thr Gly Glu 
            100                 105                 110         


Arg Cys Gln Ala Lys Leu Glu Asp Pro Cys Pro Pro Ser Phe Cys Ser 
        115                 120                 125             


Lys Arg Gly Arg Cys His Ile Gln Ala Ser Gly Arg Pro Gln Cys Ser 
    130                 135                 140                 


Cys Met Pro Gly Trp Thr Gly Glu Gln Cys Gln Leu Arg Asp Phe Cys 
145                 150                 155                 160 


Ser Ala Asn Pro Cys Val Asn Gly Gly Val Cys Leu Ala Thr Tyr Pro 
                165                 170                 175     


Gln Ile Gln Cys His Cys Pro Pro Gly Phe Glu Gly His Ala Cys Glu 
            180                 185                 190         


Arg Asp Val Asn Glu Cys Phe Gln Asp Pro Gly Pro Cys Pro Lys Gly 
        195                 200                 205             


Thr Ser Cys His Asn Thr Leu Gly Ser Phe Gln Cys Leu Cys Pro Val 
    210                 215                 220                 


Gly Gln Glu Gly Pro Arg Cys Glu Leu Arg Ala Gly Pro Cys Pro Pro 
225                 230                 235                 240 


Arg Gly Cys Ser Asn Gly Gly Thr Cys Gln Leu Met Pro Glu Lys Asp 
                245                 250                 255     


Ser Thr Phe His Leu Cys Leu Cys Pro Pro Gly Phe Ile Gly Pro Asp 
            260                 265                 270         


Cys Glu Val Asn Pro Asp Asn Cys Val Ser His Gln Cys Gln Asn Gly 
        275                 280                 285             


Gly Thr Cys Gln Asp Gly Leu Asp Thr Tyr Thr Cys Leu Cys Pro Glu 
    290                 295                 300                 


Thr Trp Thr Gly Trp Asp Cys Ser Glu Asp Val Asp Glu Cys Glu Thr 
305                 310                 315                 320 


Gln Gly Pro Pro His Cys Arg Asn Gly Gly Thr Cys Gln Asn Ser Ala 
                325                 330                 335     


Gly Ser Phe His Cys Val Cys Val Ser Gly Trp Gly Gly Thr Ser Cys 
            340                 345                 350         


Glu Glu Asn Leu Asp Asp Cys Ile Ala Ala Thr Cys Ala Pro Gly Ser 
        355                 360                 365             


Thr Cys Ile Asp Arg Val Gly Ser Phe Ser Cys Leu Cys Pro Pro Gly 
    370                 375                 380                 


Arg Thr Gly Leu Leu Cys His Leu Glu Asp Met Cys Leu Ser Gln Pro 
385                 390                 395                 400 


Cys His Gly Asp Ala Gln Cys Ser Thr Asn Pro Leu Thr Gly Ser Thr 
                405                 410                 415     


Leu Cys Leu Cys Gln Pro Gly Tyr Ser Gly Pro Thr Cys His Gln Asp 
            420                 425                 430         


Leu Asp Glu Cys Leu Met Ala Gln Gln Gly Pro Ser Pro Cys Glu His 
        435                 440                 445             


Gly Gly Ser Cys Leu Asn Thr Pro Gly Ser Phe Asn Cys Leu Cys Pro 
    450                 455                 460                 


Pro Gly Tyr Thr Gly Ser Arg Cys Glu Ala Asp His Asn Glu Cys Leu 
465                 470                 475                 480 


Ser Gln Pro Cys His Pro Gly Ser Thr Cys Leu Asp Leu Leu Ala Thr 
                485                 490                 495     


Phe His Cys Leu Cys Pro Pro Gly Leu Glu Gly Gln Leu Cys Glu Val 
            500                 505                 510         


Glu Thr Asn Glu Cys Ala Ser Ala Pro Cys Leu Asn His Ala Asp Cys 
        515                 520                 525             


His Asp Leu Leu Asn Gly Phe Gln Cys Ile Cys Leu Pro Gly Phe Ser 
    530                 535                 540                 


Gly Thr Arg Cys Glu Glu Asp Ile Asp Glu Cys Arg Ser Ser Pro Cys 
545                 550                 555                 560 


Ala Asn Gly Gly Gln Cys Gln Asp Gln Pro Gly Ala Phe His Cys Lys 
                565                 570                 575     


Cys Leu Pro Gly Phe Glu Gly Pro Arg Cys Gln Thr Glu Val Asp Glu 
            580                 585                 590         


Cys Leu Ser Asp Pro Cys Pro Val Gly Ala Ser Cys Leu Asp Leu Pro 
        595                 600                 605             


Gly Ala Phe Phe Cys Leu Cys Pro Ser Gly Phe Thr Gly Gln Leu Cys 
    610                 615                 620                 


Glu Val Pro Leu Cys Ala Pro Asn Leu Cys Gln Pro Lys Gln Ile Cys 
625                 630                 635                 640 


Lys Asp Gln Lys Asp Lys Ala Asn Cys Leu Cys Pro Asp Gly Ser Pro 
                645                 650                 655     


Gly Cys Ala Pro Pro Glu Asp Asn Cys Thr Cys His His Gly His Cys 
            660                 665                 670         


Gln Arg Ser Ser Cys Val Cys Asp Val Gly Trp Thr Gly Pro Glu Cys 
        675                 680                 685             


Glu Ala Glu Leu Gly Gly Cys Ile Ser Ala Pro Cys Ala His Gly Gly 
    690                 695                 700                 


Thr Cys Tyr Pro Gln Pro Ser Gly Tyr Asn Cys Thr Cys Pro Thr Gly 
705                 710                 715                 720 


Tyr Thr Gly Pro Thr Cys Ser Glu Glu Met Thr Ala Cys His Ser Gly 
                725                 730                 735     


Pro Cys Leu Asn Gly Gly Ser Cys Asn Pro Ser Pro Gly Gly Tyr Tyr 
            740                 745                 750         


Cys Thr Cys Pro Pro Ser His Thr Gly Pro Gln Cys Gln Thr Ser Thr 
        755                 760                 765             


Asp Tyr Cys Val Ser Ala Pro Cys Phe Asn Gly Gly Thr Cys Val Asn 
    770                 775                 780                 


Arg Pro Gly Thr Phe Ser Cys Leu Cys Ala Met Gly Phe Gln Gly Pro 
785                 790                 795                 800 


Arg Cys Glu Gly Lys Leu Arg Pro Ser Cys Ala Asp Ser Pro Cys Arg 
                805                 810                 815     


Asn Arg Ala Thr Cys Gln Asp Ser Pro Gln Gly Pro Arg Cys Leu Cys 
            820                 825                 830         


Pro Thr Gly Tyr Thr Gly Gly Ser Cys Gln Thr Leu Met Asp Leu Cys 
        835                 840                 845             


Ala Gln Lys Pro Cys Pro Arg Asn Ser His Cys Leu Gln Thr Gly Pro 
    850                 855                 860                 


Ser Phe His Cys Leu Cys Leu Gln Gly Trp Thr Gly Pro Leu Cys Asn 
865                 870                 875                 880 


Leu Pro Leu Ser Ser Cys Gln Lys Ala Ala Leu Ser Gln Gly Ile Asp 
                885                 890                 895     


Val Ser Ser Leu Cys His Asn Gly Gly Leu Cys Val Asp Ser Gly Pro 
            900                 905                 910         


Ser Tyr Phe Cys His Cys Pro Pro Gly Phe Gln Gly Ser Leu Cys Gln 
        915                 920                 925             


Asp His Val Asn Pro Cys Glu Ser Arg Pro Cys Gln Asn Gly Ala Thr 
    930                 935                 940                 


Cys Met Ala Gln Pro Ser Gly Tyr Leu Cys Gln Cys Ala Pro Gly Tyr 
945                 950                 955                 960 


Asp Gly Gln Asn Cys Ser Lys Glu Leu Asp Ala Cys Gln Ser Gln Pro 
                965                 970                 975     


Cys His Asn His Gly Thr Cys Thr Pro Lys Pro Gly Gly Phe His Cys 
            980                 985                 990         


Ala Cys Pro Pro Gly Phe Val Gly  Leu Arg Cys Glu Gly  Asp Val Asp 
        995                 1000                 1005             


Glu Cys  Leu Asp Gln Pro Cys  His Pro Thr Gly Thr  Ala Ala Cys 
    1010                 1015                 1020             


His Ser  Leu Ala Asn Ala Phe  Tyr Cys Gln Cys Leu  Pro Gly His 
    1025                 1030                 1035             


Thr Gly  Gln Trp Cys Glu Val  Glu Ile Asp Pro Cys  His Ser Gln 
    1040                 1045                 1050             


Pro Cys  Phe His Gly Gly Thr  Cys Glu Ala Thr Ala  Gly Ser Pro 
    1055                 1060                 1065             


Leu Gly  Phe Ile Cys His Cys  Pro Lys Gly Phe Glu  Gly Pro Thr 
    1070                 1075                 1080             


Cys Ser  His Arg Ala Pro Ser  Cys Gly Phe His His  Cys His His 
    1085                 1090                 1095             


Gly Gly  Leu Cys Leu Pro Ser  Pro Lys Pro Gly Phe  Pro Pro Arg 
    1100                 1105                 1110             


Cys Ala  Cys Leu Ser Gly Tyr  Gly Gly Pro Asp Cys  Leu Thr Pro 
    1115                 1120                 1125             


Pro Ala  Pro Lys Gly Cys Gly  Pro Pro Ser Pro Cys  Leu Tyr Asn 
    1130                 1135                 1140             


Gly Ser  Cys Ser Glu Thr Thr  Gly Leu Gly Gly Pro  Gly Phe Arg 
    1145                 1150                 1155             


Cys Ser  Cys Pro His Ser Ser  Pro Gly Pro Arg Cys  Gln Lys Pro 
    1160                 1165                 1170             


Gly Ala  Lys Gly Cys Glu Gly  Arg Ser Gly Asp Gly  Ala Cys Asp 
    1175                 1180                 1185             


Ala Gly  Cys Ser Gly Pro Gly  Gly Asn Trp Asp Gly  Gly Asp Cys 
    1190                 1195                 1200             


Ser Leu  Gly Val Pro Asp Pro  Trp Lys Gly Cys Pro  Ser His Ser 
    1205                 1210                 1215             


Arg Cys  Trp Leu Leu Phe Arg  Asp Gly Gln Cys His  Pro Gln Cys 
    1220                 1225                 1230             


Asp Ser  Glu Glu Cys Leu Phe  Asp Gly Tyr Asp Cys  Glu Thr Pro 
    1235                 1240                 1245             


Pro Ala  Cys Thr Pro Ala Tyr  Asp Gln Tyr Cys His  Asp His Phe 
    1250                 1255                 1260             


His Asn  Gly His Cys Glu Lys  Gly Cys Asn Thr Ala  Glu Cys Gly 
    1265                 1270                 1275             


Trp Asp  Gly Gly Asp Cys Arg  Pro Glu Asp Gly Asp  Pro Glu Trp 
    1280                 1285                 1290             


Gly Pro  Ser Leu Ala Leu Leu  Val Val Leu Ser Pro  Pro Ala Leu 
    1295                 1300                 1305             


Asp Gln  Gln Leu Phe Ala Leu  Ala Arg Val Leu Ser  Leu Thr Leu 
    1310                 1315                 1320             


Arg Val  Gly Leu Trp Val Arg  Lys Asp Arg Asp Gly  Arg Asp Met 
    1325                 1330                 1335             


Val Tyr  Pro Tyr Pro Gly Ala  Arg Ala Glu Glu Lys  Leu Gly Gly 
    1340                 1345                 1350             


Thr Arg  Asp Pro Thr Tyr Gln  Glu Arg Ala Ala Pro  Gln Thr Gln 
    1355                 1360                 1365             


Pro Leu  Gly Lys Glu Thr Asp  Ser Leu Ser Ala Gly  Phe Val Val 
    1370                 1375                 1380             


Val Met  Gly Val Asp Leu Ser  Arg Cys Gly Pro Asp  His Pro Ala 
    1385                 1390                 1395             


Ser Arg  Cys Pro Trp Asp Pro  Gly Leu Leu Leu Arg  Phe Leu Ala 
    1400                 1405                 1410             


Ala Met  Ala Ala Val Gly Ala  Leu Glu Pro Leu Leu  Pro Gly Pro 
    1415                 1420                 1425             


Leu Leu  Ala Val His Pro His  Ala Gly Thr Ala Pro  Pro Ala Asn 
    1430                 1435                 1440             


Gln Leu  Pro Trp Pro Val Leu  Cys Ser Pro Val Ala  Gly Val Ile 
    1445                 1450                 1455             


Leu Leu  Ala Leu Gly Ala Leu  Leu Val Leu Gln Leu  Ile Arg Arg 
    1460                 1465                 1470             


Arg Arg  Arg Glu His Gly Ala  Leu Trp Leu Pro Pro  Gly Phe Thr 
    1475                 1480                 1485             


Arg Arg  Pro Arg Thr Gln Ser  Ala Pro His Arg Arg  Arg Pro Pro 
    1490                 1495                 1500             


Leu Gly  Glu Asp Ser Ile Gly  Leu Lys Ala Leu Lys  Pro Lys Ala 
    1505                 1510                 1515             


Glu Val  Asp Glu Asp Gly Val  Val Met Cys Ser Gly  Pro Glu Glu 
    1520                 1525                 1530             


Gly Glu  Glu Val Gly Gln Ala  Glu Glu Thr Gly Pro  Pro Ser Thr 
    1535                 1540                 1545             


Cys Gln  Leu Trp Ser Leu Ser  Gly Gly Cys Gly Ala  Leu Pro Gln 
    1550                 1555                 1560             


Ala Ala  Met Leu Thr Pro Pro  Gln Glu Ser Glu Met  Glu Ala Pro 
    1565                 1570                 1575             


Asp Leu  Asp Thr Arg Gly Pro  Asp Gly Val Thr Pro  Leu Met Ser 
    1580                 1585                 1590             


Ala Val  Cys Cys Gly Glu Val  Gln Ser Gly Thr Phe  Gln Gly Ala 
    1595                 1600                 1605             


Trp Leu  Gly Cys Pro Glu Pro  Trp Glu Pro Leu Leu  Asp Gly Gly 
    1610                 1615                 1620             


Ala Cys  Pro Gln Ala His Thr  Val Gly Thr Gly Glu  Thr Pro Leu 
    1625                 1630                 1635             


His Leu  Ala Ala Arg Phe Ser  Arg Pro Thr Ala Ala  Arg Arg Leu 
    1640                 1645                 1650             


Leu Glu  Ala Gly Ala Asn Pro  Asn Gln Pro Asp Arg  Ala Gly Arg 
    1655                 1660                 1665             


Thr Pro  Leu His Ala Ala Val  Ala Ala Asp Ala Arg  Glu Val Cys 
    1670                 1675                 1680             


Gln Leu  Leu Leu Arg Ser Arg  Gln Thr Ala Val Asp  Ala Arg Thr 
    1685                 1690                 1695             


Glu Asp  Gly Thr Thr Pro Leu  Met Leu Ala Ala Arg  Leu Ala Val 
    1700                 1705                 1710             


Glu Asp  Leu Val Glu Glu Leu  Ile Ala Ala Gln Ala  Asp Val Gly 
    1715                 1720                 1725             


Ala Arg  Asp Lys Trp Gly Lys  Thr Ala Leu His Trp  Ala Ala Ala 
    1730                 1735                 1740             


Val Asn  Asn Ala Arg Ala Ala  Arg Ser Leu Leu Gln  Ala Gly Ala 
    1745                 1750                 1755             


Asp Lys  Asp Ala Gln Asp Asn  Arg Glu Gln Thr Pro  Leu Phe Leu 
    1760                 1765                 1770             


Ala Ala  Arg Glu Gly Ala Val  Glu Val Ala Gln Leu  Leu Leu Gly 
    1775                 1780                 1785             


Leu Gly  Ala Ala Arg Glu Leu  Arg Asp Gln Ala Gly  Leu Ala Pro 
    1790                 1795                 1800             


Ala Asp  Val Ala His Gln Arg  Asn His Trp Asp Leu  Leu Thr Leu 
    1805                 1810                 1815             


Leu Glu  Gly Ala Gly Pro Pro  Glu Ala Arg His Lys  Ala Thr Pro 
    1820                 1825                 1830             


Gly Arg  Glu Ala Gly Pro Phe  Pro Arg Ala Arg Thr  Val Ser Val 
    1835                 1840                 1845             


Ser Val  Pro Pro His Gly Gly  Gly Ala Leu Pro Arg  Cys Arg Thr 
    1850                 1855                 1860             


Leu Ser  Ala Gly Ala Gly Pro  Arg Gly Gly Gly Ala  Cys Leu Gln 
    1865                 1870                 1875             


Ala Arg  Thr Trp Ser Val Asp  Leu Ala Ala Arg Gly  Gly Gly Ala 
    1880                 1885                 1890             


Tyr Ser  His Cys Arg Ser Leu  Ser Gly Val Gly Ala  Gly Gly Gly 
    1895                 1900                 1905             


Pro Thr  Pro Arg Gly Arg Arg  Phe Ser Ala Gly Met  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Asn Pro Ala Ile Met  Arg Gly Arg Tyr Gly  Val Ala Ala 
    1925                 1930                 1935             


Gly Arg  Gly Gly Arg Val Ser  Thr Asp Asp Trp Pro  Cys Asp Trp 
    1940                 1945                 1950             


Val Ala  Leu Gly Ala Cys Gly  Ser Ala Ser Asn Ile  Pro Ile Pro 
    1955                 1960                 1965             


Pro Pro  Cys Leu Thr Pro Ser  Pro Glu Arg Gly Ser  Pro Gln Leu 
    1970                 1975                 1980             


Asp Cys  Gly Pro Pro Ala Leu  Gln Glu Met Pro Ile  Asn Gln Gly 
    1985                 1990                 1995             


Gly Glu  Gly Lys Lys 
    2000             


<210>  3076
<211>  943
<212>  PRT
<213>  Homo sapiens

<400>  3076

Met Ala Arg Gly Ser Ala Leu Pro Arg Arg Pro Leu Leu Cys Ile Pro 
1               5                   10                  15      


Ala Val Trp Ala Ala Ala Ala Leu Leu Leu Ser Val Ser Arg Thr Ser 
            20                  25                  30          


Gly Glu Val Glu Val Leu Asp Pro Asn Asp Pro Leu Gly Pro Leu Asp 
        35                  40                  45              


Gly Gln Asp Gly Pro Ile Pro Thr Leu Lys Gly Tyr Phe Leu Asn Phe 
    50                  55                  60                  


Leu Glu Pro Val Asn Asn Ile Thr Ile Val Gln Gly Gln Thr Ala Ile 
65                  70                  75                  80  


Leu His Cys Lys Val Ala Gly Asn Pro Pro Pro Asn Val Arg Trp Leu 
                85                  90                  95      


Lys Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Ile Ile Ile Arg 
            100                 105                 110         


Lys Thr Glu Tyr Gly Ser Arg Leu Arg Ile Gln Asp Leu Asp Thr Thr 
        115                 120                 125             


Asp Thr Gly Tyr Tyr Gln Cys Val Ala Thr Asn Gly Met Lys Thr Ile 
    130                 135                 140                 


Thr Ala Thr Gly Val Leu Phe Val Arg Leu Gly Pro Thr His Ser Pro 
145                 150                 155                 160 


Asn His Asn Phe Gln Asp Asp Tyr His Glu Asp Gly Phe Cys Gln Pro 
                165                 170                 175     


Tyr Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Ile Tyr 
            180                 185                 190         


Val Asp Ser Leu Gln Met Gln Gly Glu Ile Glu Asn Arg Ile Thr Ala 
        195                 200                 205             


Ala Phe Thr Met Ile Gly Thr Ser Thr His Leu Ser Asp Gln Cys Ser 
    210                 215                 220                 


Gln Phe Ala Ile Pro Ser Phe Cys His Phe Val Phe Pro Leu Cys Asp 
225                 230                 235                 240 


Ala Arg Ser Arg Thr Pro Lys Pro Arg Glu Leu Cys Arg Asp Glu Cys 
                245                 250                 255     


Glu Val Leu Glu Ser Asp Leu Cys Arg Gln Glu Tyr Thr Ile Ala Arg 
            260                 265                 270         


Ser Asn Pro Leu Ile Leu Met Arg Leu Gln Leu Pro Lys Cys Glu Ala 
        275                 280                 285             


Leu Pro Met Pro Glu Ser Pro Asp Ala Ala Asn Cys Met Arg Ile Gly 
    290                 295                 300                 


Ile Pro Ala Glu Arg Leu Gly Arg Tyr His Gln Cys Tyr Asn Gly Ser 
305                 310                 315                 320 


Gly Met Asp Tyr Arg Gly Thr Ala Ser Thr Thr Lys Ser Gly His Gln 
                325                 330                 335     


Cys Gln Pro Trp Ala Leu Gln His Pro His Ser His His Leu Ser Ser 
            340                 345                 350         


Thr Asp Phe Pro Glu Leu Gly Gly Gly His Ala Tyr Cys Arg Asn Pro 
        355                 360                 365             


Gly Gly Gln Met Glu Gly Pro Trp Cys Phe Thr Gln Asn Lys Asn Val 
    370                 375                 380                 


Arg Met Glu Leu Cys Asp Val Pro Ser Cys Ser Pro Arg Asp Ser Ser 
385                 390                 395                 400 


Lys Met Gly Ile Leu Tyr Ile Leu Val Pro Ser Ile Ala Ile Pro Leu 
                405                 410                 415     


Val Ile Ala Cys Leu Phe Phe Leu Val Cys Met Cys Arg Asn Lys Gln 
            420                 425                 430         


Lys Ala Ser Ala Ser Thr Pro Gln Arg Arg Gln Leu Met Ala Ser Pro 
        435                 440                 445             


Ser Gln Asp Met Glu Met Pro Leu Ile Asn Gln His Lys Gln Ala Lys 
    450                 455                 460                 


Leu Lys Glu Ile Ser Leu Ser Ala Val Arg Phe Met Glu Glu Leu Gly 
465                 470                 475                 480 


Glu Asp Arg Phe Gly Lys Val Tyr Lys Gly His Leu Phe Gly Pro Ala 
                485                 490                 495     


Pro Gly Glu Gln Thr Gln Ala Val Ala Ile Lys Thr Leu Lys Asp Lys 
            500                 505                 510         


Ala Glu Gly Pro Leu Arg Glu Glu Phe Arg His Glu Ala Met Leu Arg 
        515                 520                 525             


Ala Arg Leu Gln His Pro Asn Val Val Cys Leu Leu Gly Val Val Thr 
    530                 535                 540                 


Lys Asp Gln Pro Leu Ser Met Ile Phe Ser Tyr Cys Ser His Gly Asp 
545                 550                 555                 560 


Leu His Glu Phe Leu Val Met Arg Ser Pro His Ser Asp Val Gly Ser 
                565                 570                 575     


Thr Asp Asp Asp Arg Thr Val Lys Ser Ala Leu Glu Pro Pro Asp Phe 
            580                 585                 590         


Val His Leu Val Ala Gln Ile Ala Ala Gly Met Glu Tyr Leu Ser Ser 
        595                 600                 605             


His His Val Val His Lys Asp Leu Ala Thr Arg Asn Val Leu Val Tyr 
    610                 615                 620                 


Asp Lys Leu Asn Val Lys Ile Ser Asp Leu Gly Leu Phe Arg Glu Val 
625                 630                 635                 640 


Tyr Ala Ala Asp Tyr Tyr Lys Leu Leu Gly Asn Ser Leu Leu Pro Ile 
                645                 650                 655     


Arg Trp Met Ala Pro Glu Ala Ile Met Tyr Gly Lys Phe Ser Ile Asp 
            660                 665                 670         


Ser Asp Ile Trp Ser Tyr Gly Val Val Leu Trp Glu Val Phe Ser Tyr 
        675                 680                 685             


Gly Leu Gln Pro Tyr Cys Gly Tyr Ser Asn Gln Asp Val Val Glu Met 
    690                 695                 700                 


Ile Arg Asn Arg Gln Val Leu Pro Cys Pro Asp Asp Cys Pro Ala Trp 
705                 710                 715                 720 


Val Tyr Ala Leu Met Ile Glu Cys Trp Asn Glu Phe Pro Ser Arg Arg 
                725                 730                 735     


Pro Arg Phe Lys Asp Ile His Ser Arg Leu Arg Ala Trp Gly Asn Leu 
            740                 745                 750         


Ser Asn Tyr Asn Ser Ser Ala Gln Thr Ser Gly Ala Ser Asn Thr Thr 
        755                 760                 765             


Gln Thr Ser Ser Leu Ser Thr Ser Pro Val Ser Asn Val Ser Asn Ala 
    770                 775                 780                 


Arg Tyr Val Gly Pro Lys Gln Lys Ala Pro Pro Phe Pro Gln Pro Gln 
785                 790                 795                 800 


Phe Ile Pro Met Lys Gly Gln Ile Arg Pro Met Val Pro Pro Pro Gln 
                805                 810                 815     


Leu Tyr Val Pro Val Asn Gly Tyr Gln Pro Val Pro Ala Tyr Gly Ala 
            820                 825                 830         


Tyr Leu Pro Asn Phe Tyr Pro Val Gln Ile Pro Met Gln Met Ala Pro 
        835                 840                 845             


Gln Gln Val Pro Pro Gln Met Val Pro Lys Pro Ser Ser His His Ser 
    850                 855                 860                 


Gly Ser Gly Ser Thr Ser Thr Gly Tyr Val Thr Thr Ala Pro Ser Asn 
865                 870                 875                 880 


Thr Ser Met Ala Asp Arg Ala Ala Leu Leu Ser Glu Gly Ala Asp Asp 
                885                 890                 895     


Thr Gln Asn Ala Pro Glu Asp Gly Ala Gln Ser Thr Val Gln Glu Ala 
            900                 905                 910         


Glu Glu Glu Glu Glu Gly Ser Val Pro Glu Thr Glu Leu Leu Gly Asp 
        915                 920                 925             


Cys Asp Thr Leu Gln Val Asp Glu Ala Gln Val Gln Leu Glu Ala 
    930                 935                 940             


<210>  3077
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  3077

Met Glu Asp Glu Arg Ser Phe Ser Asp Ile Cys Gly Gly Arg Leu Ala 
1               5                   10                  15      


Leu Gln Arg Arg Tyr Tyr Ser Pro Ser Cys Arg Glu Phe Cys Leu Ser 
            20                  25                  30          


Cys Pro Arg Leu Ser Leu Arg Ser Leu Thr Ala Val Thr Cys Thr Val 
        35                  40                  45              


Trp Leu Ala Ala Tyr Gly Leu Phe Thr Leu Cys Glu Asn Ser Met Ile 
    50                  55                  60                  


Leu Ser Ala Ala Ile Phe Ile Thr Leu Leu Gly Leu Leu Gly Tyr Leu 
65                  70                  75                  80  


His Phe Val Lys Ile Asp Gln Glu Thr Leu Leu Ile Ile Asp Ser Leu 
                85                  90                  95      


Gly Ile Gln Met Thr Ser Ser Tyr Ala Ser Gly Lys Glu Ser Thr Thr 
            100                 105                 110         


Phe Ile Glu Met Gly Lys Val Lys Asp Ile Val Ile Asn Glu Ala Ile 
        115                 120                 125             


Tyr Met Gln Lys Val Ile Tyr Tyr Leu Cys Ile Leu Leu Lys Asp Pro 
    130                 135                 140                 


Val Glu Pro His Gly Ile Ser Gln Val Val Pro Val Phe Gln Ser Ala 
145                 150                 155                 160 


Lys Pro Arg Leu Asp Cys Leu Ile Glu Val Tyr Arg Ser Cys Gln Glu 
                165                 170                 175     


Ile Leu Ala His Gln Lys Ala Thr Ser Thr Ser Pro 
            180                 185             


<210>  3078
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  3078

Met Ala Ser Pro His Gln Glu Pro Lys Pro Gly Asp Leu Ile Glu Ile 
1               5                   10                  15      


Phe Arg Leu Gly Tyr Glu His Trp Ala Leu Tyr Ile Gly Asp Gly Tyr 
            20                  25                  30          


Val Ile His Leu Ala Pro Pro Ser Glu Tyr Pro Gly Ala Gly Ser Ser 
        35                  40                  45              


Ser Val Phe Ser Val Leu Ser Asn Ser Ala Glu Val Lys Arg Glu Arg 
    50                  55                  60                  


Leu Glu Asp Val Val Gly Gly Cys Cys Tyr Arg Val Asn Asn Ser Leu 
65                  70                  75                  80  


Asp His Glu Tyr Gln Pro Arg Pro Val Glu Val Ile Ile Ser Ser Ala 
                85                  90                  95      


Lys Glu Met Val Gly Gln Lys Met Lys Tyr Ser Ile Val Ser Arg Asn 
            100                 105                 110         


Cys Glu His Phe Val Thr Gln Leu Arg Tyr Gly Lys Ser Arg Cys Lys 
        115                 120                 125             


Gln Val Glu Lys Ala Lys Val Glu Val Gly Val Ala Thr Ala Leu Gly 
    130                 135                 140                 


Ile Leu Val Val Ala Gly Cys Ser Phe Ala Ile Arg Arg Tyr Gln Lys 
145                 150                 155                 160 


Lys Ala Thr Ala 
                


<210>  3079
<211>  977
<212>  PRT
<213>  Homo sapiens

<400>  3079

Met Asp Ile Tyr Asp Thr Gln Thr Leu Gly Val Val Val Phe Gly Gly 
1               5                   10                  15      


Phe Met Val Val Ser Ala Ile Gly Ile Phe Leu Val Ser Thr Phe Ser 
            20                  25                  30          


Met Lys Glu Thr Ser Tyr Glu Glu Ala Leu Ala Asn Gln Arg Lys Glu 
        35                  40                  45              


Met Ala Lys Thr His His Gln Lys Val Glu Lys Lys Lys Lys Glu Lys 
    50                  55                  60                  


Thr Val Glu Lys Lys Gly Lys Thr Lys Lys Lys Glu Glu Lys Pro Asn 
65                  70                  75                  80  


Gly Lys Ile Pro Asp His Asp Pro Ala Pro Asn Val Thr Val Leu Leu 
                85                  90                  95      


Arg Glu Pro Val Arg Ala Pro Ala Val Ala Val Ala Pro Thr Pro Val 
            100                 105                 110         


Gln Pro Pro Ile Ile Val Ala Pro Val Ala Thr Val Pro Ala Met Pro 
        115                 120                 125             


Gln Glu Lys Leu Ala Ser Ser Pro Lys Asp Lys Lys Lys Lys Glu Lys 
    130                 135                 140                 


Lys Val Ala Lys Val Glu Pro Ala Val Ser Ser Val Val Asn Ser Ile 
145                 150                 155                 160 


Gln Val Leu Thr Ser Lys Ala Ala Ile Leu Glu Thr Ala Pro Lys Glu 
                165                 170                 175     


Gly Arg Asn Thr Asp Val Ala Gln Ser Pro Glu Ala Pro Lys Gln Glu 
            180                 185                 190         


Ala Pro Ala Lys Lys Lys Ser Gly Ser Lys Lys Lys Gly Pro Pro Asp 
        195                 200                 205             


Ala Asp Gly Pro Leu Tyr Leu Pro Tyr Lys Thr Leu Val Ser Thr Val 
    210                 215                 220                 


Gly Ser Met Val Phe Asn Glu Gly Glu Ala Gln Arg Leu Ile Glu Ile 
225                 230                 235                 240 


Leu Ser Glu Lys Ala Gly Ile Ile Gln Asp Thr Trp His Lys Ala Thr 
                245                 250                 255     


Gln Lys Gly Asp Pro Val Ala Ile Leu Lys Arg Gln Leu Glu Glu Lys 
            260                 265                 270         


Glu Lys Leu Leu Ala Thr Glu Gln Glu Asp Ala Ala Val Ala Lys Ser 
        275                 280                 285             


Lys Leu Arg Glu Leu Asn Lys Glu Met Ala Ala Glu Lys Ala Lys Ala 
    290                 295                 300                 


Ala Ala Gly Glu Ala Lys Val Lys Lys Gln Leu Val Ala Arg Glu Gln 
305                 310                 315                 320 


Glu Ile Thr Ala Val Gln Ala Arg Met Gln Ala Ser Tyr Arg Glu His 
                325                 330                 335     


Val Lys Glu Val Gln Gln Leu Gln Gly Lys Ile Arg Thr Leu Gln Glu 
            340                 345                 350         


Gln Leu Glu Asn Gly Pro Asn Thr Gln Leu Ala Arg Leu Gln Gln Glu 
        355                 360                 365             


Asn Ser Ile Leu Arg Asp Ala Leu Asn Gln Ala Thr Ser Gln Val Glu 
    370                 375                 380                 


Ser Lys Gln Asn Ala Glu Leu Ala Lys Leu Arg Gln Glu Leu Ser Lys 
385                 390                 395                 400 


Val Ser Lys Glu Leu Val Glu Lys Ser Glu Ala Val Arg Gln Asp Glu 
                405                 410                 415     


Gln Gln Arg Lys Ala Leu Glu Ala Lys Ala Ala Ala Phe Glu Lys Gln 
            420                 425                 430         


Val Leu Gln Leu Gln Ala Ser His Arg Glu Ser Glu Glu Ala Leu Gln 
        435                 440                 445             


Lys Arg Leu Asp Glu Val Ser Arg Glu Leu Cys His Thr Gln Ser Ser 
    450                 455                 460                 


His Ala Ser Leu Arg Ala Asp Ala Glu Lys Ala Gln Glu Gln Gln Gln 
465                 470                 475                 480 


Gln Met Ala Glu Leu His Ser Lys Leu Gln Ser Ser Glu Ala Glu Val 
                485                 490                 495     


Arg Ser Lys Cys Glu Glu Leu Ser Gly Leu His Gly Gln Leu Gln Glu 
            500                 505                 510         


Ala Arg Ala Glu Asn Ser Gln Leu Thr Glu Arg Ile Arg Ser Ile Glu 
        515                 520                 525             


Ala Leu Leu Glu Ala Gly Gln Ala Arg Asp Ala Gln Asp Val Gln Ala 
    530                 535                 540                 


Ser Gln Ala Glu Ala Asp Gln Gln Gln Thr Arg Leu Lys Glu Leu Glu 
545                 550                 555                 560 


Ser Gln Val Ser Gly Leu Glu Lys Glu Ala Ile Glu Leu Arg Glu Ala 
                565                 570                 575     


Val Glu Gln Gln Lys Val Lys Asn Asn Asp Leu Arg Glu Lys Asn Trp 
            580                 585                 590         


Lys Ala Met Glu Ala Leu Ala Thr Ala Glu Gln Ala Cys Lys Glu Lys 
        595                 600                 605             


Leu His Ser Leu Thr Gln Ala Lys Glu Glu Ser Glu Lys Gln Leu Cys 
    610                 615                 620                 


Leu Ile Glu Ala Gln Thr Met Glu Ala Leu Leu Ala Leu Leu Pro Glu 
625                 630                 635                 640 


Leu Ser Val Leu Ala Gln Gln Asn Tyr Thr Glu Trp Leu Gln Asp Leu 
                645                 650                 655     


Lys Glu Lys Gly Pro Thr Leu Leu Lys His Pro Pro Ala Pro Ala Glu 
            660                 665                 670         


Pro Ser Ser Asp Leu Ala Ser Lys Leu Arg Glu Ala Glu Glu Thr Gln 
        675                 680                 685             


Ser Thr Leu Gln Ala Glu Cys Asp Gln Tyr Arg Ser Ile Leu Ala Glu 
    690                 695                 700                 


Thr Glu Gly Met Leu Arg Asp Leu Gln Lys Ser Val Glu Glu Glu Glu 
705                 710                 715                 720 


Gln Val Trp Arg Ala Lys Val Gly Ala Ala Glu Glu Glu Leu Gln Lys 
                725                 730                 735     


Ser Arg Val Thr Val Lys His Leu Glu Glu Ile Val Glu Lys Leu Lys 
            740                 745                 750         


Gly Glu Leu Glu Ser Ser Asp Gln Val Arg Glu His Thr Ser His Leu 
        755                 760                 765             


Glu Ala Glu Leu Glu Lys His Met Ala Ala Ala Ser Ala Glu Cys Gln 
    770                 775                 780                 


Asn Tyr Ala Lys Glu Val Ala Gly Leu Arg Gln Leu Leu Leu Glu Ser 
785                 790                 795                 800 


Gln Ser Gln Leu Asp Ala Ala Lys Ser Glu Ala Gln Lys Gln Ser Asp 
                805                 810                 815     


Glu Leu Ala Leu Val Arg Gln Gln Leu Ser Glu Met Lys Ser His Val 
            820                 825                 830         


Glu Asp Gly Asp Ile Ala Gly Ala Pro Ala Ser Ser Pro Glu Ala Pro 
        835                 840                 845             


Pro Ala Glu Gln Asp Pro Val Gln Leu Lys Thr Gln Leu Glu Trp Thr 
    850                 855                 860                 


Glu Ala Ile Leu Glu Asp Glu Gln Thr Gln Arg Gln Lys Leu Thr Ala 
865                 870                 875                 880 


Glu Phe Glu Glu Ala Gln Thr Ser Ala Cys Arg Leu Gln Glu Glu Leu 
                885                 890                 895     


Glu Lys Leu Arg Thr Ala Gly Pro Leu Glu Ser Ser Glu Thr Glu Glu 
            900                 905                 910         


Ala Ser Gln Leu Lys Glu Arg Leu Glu Lys Glu Lys Lys Leu Thr Ser 
        915                 920                 925             


Asp Leu Gly Arg Ala Ala Thr Arg Leu Gln Glu Leu Leu Lys Thr Thr 
    930                 935                 940                 


Gln Glu Gln Leu Ala Arg Glu Lys Asp Thr Val Lys Lys Leu Gln Glu 
945                 950                 955                 960 


Gln Leu Glu Lys Ala Glu Asp Gly Ser Ser Ser Lys Glu Gly Thr Ser 
                965                 970                 975     


Val 
    


<210>  3080
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  3080

Met His Arg Asp Ala Trp Leu Pro Arg Pro Ala Phe Ser Leu Thr Gly 
1               5                   10                  15      


Leu Ser Leu Phe Phe Ser Leu Val Pro Pro Gly Arg Ser Met Glu Val 
            20                  25                  30          


Thr Val Pro Ala Thr Leu Asn Val Leu Asn Gly Ser Asp Ala Arg Leu 
        35                  40                  45              


Pro Cys Thr Phe Asn Ser Cys Tyr Thr Val Asn His Lys Gln Phe Ser 
    50                  55                  60                  


Leu Asn Trp Thr Tyr Gln Glu Cys Asn Asn Cys Ser Glu Glu Met Phe 
65                  70                  75                  80  


Leu Gln Phe Arg Met Lys Ile Ile Asn Leu Lys Leu Glu Arg Phe Gln 
                85                  90                  95      


Asp Arg Val Glu Phe Ser Gly Asn Pro Ser Lys Tyr Asp Val Ser Val 
            100                 105                 110         


Met Leu Arg Asn Val Gln Pro Glu Asp Glu Gly Ile Tyr Asn Cys Tyr 
        115                 120                 125             


Ile Met Asn Pro Pro Asp Arg His Arg Gly His Gly Lys Ile His Leu 
    130                 135                 140                 


Gln Val Leu Met Glu Glu Pro Pro Glu Arg Asp Ser Thr Val Ala Val 
145                 150                 155                 160 


Ile Val Gly Ala Ser Val Gly Gly Phe Leu Ala Val Val Ile Leu Val 
                165                 170                 175     


Leu Met Val Val Lys Cys Val Arg Arg Lys Lys Glu Gln Lys Leu Ser 
            180                 185                 190         


Thr Asp Asp Leu Lys Thr Glu Glu Glu Gly Lys Thr Asp Gly Glu Gly 
        195                 200                 205             


Asn Pro Asp Asp Gly Ala Lys 
    210                 215 


<210>  3081
<211>  896
<212>  PRT
<213>  Homo sapiens

<400>  3081

Met Leu Arg Ala Ala Leu Ser Leu Leu Ala Leu Pro Leu Ala Gly Ala 
1               5                   10                  15      


Ala Glu Glu Pro Thr Gln Lys Pro Glu Ser Pro Gly Glu Pro Pro Pro 
            20                  25                  30          


Gly Leu Glu Leu Phe Arg Trp Gln Trp His Glu Val Glu Ala Pro Tyr 
        35                  40                  45              


Leu Val Ala Leu Trp Ile Leu Val Ala Ser Leu Ala Lys Ile Val Phe 
    50                  55                  60                  


His Leu Ser Arg Lys Val Thr Ser Leu Val Pro Glu Ser Cys Leu Leu 
65                  70                  75                  80  


Ile Leu Leu Gly Leu Val Leu Gly Gly Ile Val Leu Ala Val Ala Lys 
                85                  90                  95      


Lys Ala Glu Tyr Gln Leu Glu Pro Gly Thr Phe Phe Leu Phe Leu Leu 
            100                 105                 110         


Pro Pro Ile Val Leu Asp Ser Gly Tyr Phe Met Pro Ser Arg Leu Phe 
        115                 120                 125             


Phe Asp Asn Leu Gly Ala Ile Leu Thr Tyr Ala Val Val Gly Thr Leu 
    130                 135                 140                 


Trp Asn Ala Phe Thr Thr Gly Ala Ala Leu Trp Gly Leu Gln Gln Ala 
145                 150                 155                 160 


Gly Leu Val Ala Pro Arg Val Gln Ala Gly Leu Leu Asp Phe Leu Leu 
                165                 170                 175     


Phe Gly Ser Leu Ile Ser Ala Val Asp Pro Val Ala Val Leu Ala Val 
            180                 185                 190         


Phe Glu Glu Val His Val Asn Glu Thr Leu Phe Ile Ile Val Phe Gly 
        195                 200                 205             


Glu Ser Leu Leu Asn Asp Ala Val Thr Val Val Leu Tyr Lys Val Cys 
    210                 215                 220                 


Asn Ser Phe Val Glu Met Gly Ser Ala Asn Val Gln Ala Thr Asp Tyr 
225                 230                 235                 240 


Leu Lys Gly Val Ala Ser Leu Phe Val Val Ser Leu Gly Gly Ala Ala 
                245                 250                 255     


Val Gly Leu Val Phe Ala Phe Leu Leu Ala Leu Thr Thr Arg Phe Thr 
            260                 265                 270         


Lys Arg Val Arg Ile Ile Glu Pro Leu Leu Val Phe Leu Leu Ala Tyr 
        275                 280                 285             


Ala Ala Tyr Leu Thr Ala Glu Met Ala Ser Leu Ser Ala Ile Leu Ala 
    290                 295                 300                 


Val Thr Met Cys Gly Leu Gly Cys Lys Lys Tyr Val Glu Ala Asn Ile 
305                 310                 315                 320 


Ser His Lys Ser Arg Thr Thr Val Lys Tyr Thr Met Lys Thr Leu Ala 
                325                 330                 335     


Ser Cys Ala Glu Thr Val Ile Phe Met Leu Leu Gly Ile Ser Ala Val 
            340                 345                 350         


Asp Ser Ser Lys Trp Ala Trp Asp Ser Gly Leu Val Leu Gly Thr Leu 
        355                 360                 365             


Ile Phe Ile Leu Phe Phe Arg Ala Leu Gly Val Val Leu Gln Thr Trp 
    370                 375                 380                 


Val Leu Asn Gln Phe Arg Leu Val Pro Leu Asp Lys Ile Asp Gln Val 
385                 390                 395                 400 


Val Met Ser Tyr Gly Gly Leu Arg Gly Ala Val Ala Phe Ala Leu Val 
                405                 410                 415     


Ile Leu Leu Asp Arg Thr Lys Val Pro Ala Lys Asp Tyr Phe Val Ala 
            420                 425                 430         


Thr Thr Ile Val Val Val Phe Phe Thr Val Ile Val Gln Gly Leu Thr 
        435                 440                 445             


Ile Lys Pro Leu Val Lys Trp Leu Lys Val Lys Arg Ser Glu His His 
    450                 455                 460                 


Lys Pro Thr Leu Asn Gln Glu Leu His Glu His Thr Phe Asp His Ile 
465                 470                 475                 480 


Leu Ala Ala Val Glu Asp Val Val Gly His His Gly Tyr His Tyr Trp 
                485                 490                 495     


Arg Asp Arg Trp Glu Gln Phe Asp Lys Lys Tyr Leu Ser Gln Leu Leu 
            500                 505                 510         


Met Arg Arg Ser Ala Tyr Arg Ile Arg Asp Gln Ile Trp Asp Val Tyr 
        515                 520                 525             


Tyr Arg Leu Asn Ile Arg Asp Ala Ile Ser Phe Val Asp Gln Gly Gly 
    530                 535                 540                 


His Val Leu Ser Ser Thr Gly Leu Thr Leu Pro Ser Met Pro Ser Arg 
545                 550                 555                 560 


Asn Ser Val Ala Glu Thr Ser Val Thr Asn Leu Leu Arg Glu Ser Gly 
                565                 570                 575     


Ser Gly Ala Cys Leu Asp Leu Gln Val Ile Asp Thr Val Arg Ser Gly 
            580                 585                 590         


Arg Asp Arg Glu Asp Ala Val Met His His Leu Leu Cys Gly Gly Leu 
        595                 600                 605             


Tyr Lys Pro Arg Arg Arg Tyr Lys Ala Ser Cys Ser Arg His Phe Ile 
    610                 615                 620                 


Ser Glu Asp Ala Gln Glu Arg Gln Asp Lys Glu Val Phe Gln Gln Asn 
625                 630                 635                 640 


Met Lys Arg Arg Leu Glu Ser Phe Lys Ser Thr Lys His Asn Ile Cys 
                645                 650                 655     


Phe Thr Lys Ser Lys Pro Arg Pro Arg Lys Thr Gly Arg Arg Lys Lys 
            660                 665                 670         


Asp Gly Val Ala Asn Ala Glu Ala Thr Asn Gly Lys His Arg Gly Leu 
        675                 680                 685             


Gly Phe Gln Asp Thr Ala Ala Val Ile Leu Thr Val Glu Ser Glu Glu 
    690                 695                 700                 


Glu Glu Glu Glu Ser Asp Ser Ser Glu Thr Glu Lys Glu Asp Asp Glu 
705                 710                 715                 720 


Gly Ile Ile Phe Val Ala Arg Ala Thr Ser Glu Val Leu Gln Glu Gly 
                725                 730                 735     


Lys Val Ser Gly Ser Leu Glu Val Cys Pro Ser Pro Arg Ile Ile Pro 
            740                 745                 750         


Pro Ser Pro Thr Cys Ala Glu Lys Glu Leu Pro Trp Lys Ser Gly Gln 
        755                 760                 765             


Gly Asp Leu Ala Val Tyr Val Ser Ser Glu Thr Thr Lys Ile Val Pro 
    770                 775                 780                 


Val Asp Met Gln Thr Gly Trp Asn Gln Ser Ile Ser Ser Leu Glu Ser 
785                 790                 795                 800 


Leu Ala Ser Pro Pro Cys Asn Gln Ala Pro Ile Leu Thr Cys Leu Pro 
                805                 810                 815     


Pro His Pro Arg Gly Thr Glu Glu Pro Gln Val Pro Leu His Leu Pro 
            820                 825                 830         


Ser Asp Pro Arg Ser Ser Phe Ala Phe Pro Pro Ser Leu Ala Lys Ala 
        835                 840                 845             


Gly Arg Ser Arg Ser Glu Ser Ser Ala Asp Leu Pro Gln Gln Gln Glu 
    850                 855                 860                 


Leu Gln Pro Leu Met Gly His Lys Asp His Thr His Leu Ser Pro Gly 
865                 870                 875                 880 


Thr Ala Thr Ser His Trp Cys Ile Gln Phe Asn Arg Gly Ser Arg Leu 
                885                 890                 895     


<210>  3082
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  3082

Met Arg Asp Arg Thr His Glu Leu Arg Gln Gly Asp Asp Ser Ser Asp 
1               5                   10                  15      


Glu Glu Asp Lys Glu Arg Val Ala Leu Val Val His Pro Gly Thr Ala 
            20                  25                  30          


Arg Leu Gly Ser Pro Asp Glu Glu Phe Phe His Lys Val Arg Thr Ile 
        35                  40                  45              


Arg Gln Thr Ile Val Lys Leu Gly Asn Lys Val Gln Glu Leu Glu Lys 
    50                  55                  60                  


Gln Gln Val Thr Ile Leu Ala Thr Pro Leu Pro Glu Glu Ser Met Lys 
65                  70                  75                  80  


Gln Glu Leu Gln Asn Leu Arg Asp Glu Ile Lys Gln Leu Gly Arg Glu 
                85                  90                  95      


Ile Arg Leu Gln Leu Lys Ala Ile Glu Pro Gln Lys Glu Glu Ala Asp 
            100                 105                 110         


Glu Asn Tyr Asn Ser Val Asn Thr Arg Met Arg Lys Thr Gln His Gly 
        115                 120                 125             


Val Leu Ser Gln Gln Phe Val Glu Leu Ile Asn Lys Cys Asn Ser Met 
    130                 135                 140                 


Gln Ser Glu Tyr Arg Glu Lys Asn Val Glu Arg Ile Arg Arg Gln Leu 
145                 150                 155                 160 


Lys Ile Thr Asn Ala Gly Met Val Ser Asp Glu Glu Leu Glu Gln Met 
                165                 170                 175     


Leu Asp Ser Gly Gln Ser Glu Val Phe Val Ser Asn Ile Leu Lys Asp 
            180                 185                 190         


Thr Gln Val Thr Arg Gln Ala Leu Asn Glu Ile Ser Ala Arg His Ser 
        195                 200                 205             


Glu Ile Gln Gln Leu Glu Arg Ser Ile Arg Glu Leu His Asp Ile Phe 
    210                 215                 220                 


Thr Phe Leu Ala Thr Glu Val Glu Met Gln Gly Glu Met Ile Asn Arg 
225                 230                 235                 240 


Ile Glu Lys Asn Ile Leu Ser Ser Ala Asp Tyr Val Glu Arg Gly Gln 
                245                 250                 255     


Glu His Val Lys Thr Ala Leu Glu Asn Gln Lys Lys Ala Arg Lys Lys 
            260                 265                 270         


Lys Val Leu Ile Ala Ile Cys Val Ser Ile Thr Val Val Leu Leu Ala 
        275                 280                 285             


Val Ile Ile Gly Val Thr Val Val Gly 
    290                 295         


<210>  3083
<211>  503
<212>  PRT
<213>  Homo sapiens

<400>  3083

Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr 
            20                  25                  30          


Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys 
        35                  40                  45              


Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys 
    50                  55                  60                  


Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg 
65                  70                  75                  80  


Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr 
                85                  90                  95      


Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro 
            100                 105                 110         


Thr Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu Ala Ala 
        115                 120                 125             


Val Ile Ala Gly Pro Val Cys Phe Val Cys Ile Ser Leu Met Leu Met 
    130                 135                 140                 


Val Tyr Ile Cys His Asn Arg Thr Val Ile His His Arg Val Pro Asn 
145                 150                 155                 160 


Glu Glu Asp Pro Ser Leu Asp Arg Pro Phe Ile Ser Glu Gly Thr Thr 
                165                 170                 175     


Leu Lys Asp Leu Ile Tyr Asp Met Thr Thr Ser Gly Ser Gly Ser Gly 
            180                 185                 190         


Leu Pro Leu Leu Val Gln Arg Thr Ile Ala Arg Thr Ile Val Leu Gln 
        195                 200                 205             


Glu Ser Ile Gly Lys Gly Arg Phe Gly Glu Val Trp Arg Gly Lys Trp 
    210                 215                 220                 


Arg Gly Glu Glu Val Ala Val Lys Ile Phe Ser Ser Arg Glu Glu Arg 
225                 230                 235                 240 


Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Thr Val Met Leu Arg His 
                245                 250                 255     


Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys Asp Asn Gly Thr 
            260                 265                 270         


Trp Thr Gln Leu Trp Leu Val Ser Asp Tyr His Glu His Gly Ser Leu 
        275                 280                 285             


Phe Asp Tyr Leu Asn Arg Tyr Thr Val Thr Val Glu Gly Met Ile Lys 
    290                 295                 300                 


Leu Ala Leu Ser Thr Ala Ser Gly Leu Ala His Leu His Met Glu Ile 
305                 310                 315                 320 


Val Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser 
                325                 330                 335     


Lys Asn Ile Leu Val Lys Lys Asn Gly Thr Cys Cys Ile Ala Asp Leu 
            340                 345                 350         


Gly Leu Ala Val Arg His Asp Ser Ala Thr Asp Thr Ile Asp Ile Ala 
        355                 360                 365             


Pro Asn His Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu 
    370                 375                 380                 


Asp Asp Ser Ile Asn Met Lys His Phe Glu Ser Phe Lys Arg Ala Asp 
385                 390                 395                 400 


Ile Tyr Ala Met Gly Leu Val Phe Trp Glu Ile Ala Arg Arg Cys Ser 
                405                 410                 415     


Ile Gly Gly Ile His Glu Asp Tyr Gln Leu Pro Tyr Tyr Asp Leu Val 
            420                 425                 430         


Pro Ser Asp Pro Ser Val Glu Glu Met Arg Lys Val Val Cys Glu Gln 
        435                 440                 445             


Lys Leu Arg Pro Asn Ile Pro Asn Arg Trp Gln Ser Cys Glu Ala Leu 
    450                 455                 460                 


Arg Val Met Ala Lys Ile Met Arg Glu Cys Trp Tyr Ala Asn Gly Ala 
465                 470                 475                 480 


Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Ser Gln Leu Ser 
                485                 490                 495     


Gln Gln Glu Gly Ile Lys Met 
            500             


<210>  3084
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  3084

Met Ala Ser Arg Arg Met Glu Thr Lys Pro Val Ile Thr Cys Leu Lys 
1               5                   10                  15      


Thr Leu Leu Ile Ile Tyr Ser Phe Val Phe Trp Ile Thr Gly Val Ile 
            20                  25                  30          


Leu Leu Ala Val Gly Val Trp Gly Lys Leu Thr Leu Gly Thr Tyr Ile 
        35                  40                  45              


Ser Leu Ile Ala Glu Asn Ser Thr Asn Ala Pro Tyr Val Leu Ile Gly 
    50                  55                  60                  


Thr Gly Thr Thr Ile Val Val Phe Gly Leu Phe Gly Cys Phe Ala Thr 
65                  70                  75                  80  


Cys Arg Gly Ser Pro Trp Met Leu Lys Leu Tyr Ala Met Phe Leu Ser 
                85                  90                  95      


Leu Val Phe Leu Ala Glu Leu Val Ala Gly Ile Ser Gly Phe Val Phe 
            100                 105                 110         


Arg His Glu Ile Lys Asp Thr Phe Leu Arg Thr Tyr Thr Asp Ala Met 
        115                 120                 125             


Gln Thr Tyr Asn Gly Asn Asp Glu Arg Ser Arg Ala Val Asp His Val 
    130                 135                 140                 


Gln Arg Ser Leu Ser Cys Cys Gly Val Gln Asn Tyr Thr Asn Trp Ser 
145                 150                 155                 160 


Thr Ser Pro Tyr Phe Leu Glu His Gly Ile Pro Pro Ser Cys Cys Met 
                165                 170                 175     


Asn Glu Thr Asp Cys Asn Pro Gln Asp Leu His Asn Leu Thr Val Ala 
            180                 185                 190         


Ala Thr Lys Val Asn Gln Lys Gly Cys Tyr Asp Leu Val Thr Ser Phe 
        195                 200                 205             


Met Glu Thr Asn Met Gly Ile Ile Ala Gly Val Ala Phe Gly Ile Ala 
    210                 215                 220                 


Phe Ser Gln Leu Ile Gly Met Leu Leu Ala Cys Cys Leu Ser Arg Phe 
225                 230                 235                 240 


Ile Thr Ala Asn Gln Tyr Glu Met Val 
                245                 


<210>  3085
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  3085

Met Ala Gly Val Ser Ala Cys Ile Lys Tyr Ser Met Phe Thr Phe Asn 
1               5                   10                  15      


Phe Leu Phe Trp Leu Cys Gly Ile Leu Ile Leu Ala Leu Ala Ile Trp 
            20                  25                  30          


Val Arg Val Ser Asn Asp Ser Gln Ala Ile Phe Gly Ser Glu Asp Val 
        35                  40                  45              


Gly Ser Ser Ser Tyr Val Ala Val Asp Ile Leu Ile Ala Val Gly Ala 
    50                  55                  60                  


Ile Ile Met Ile Leu Gly Phe Leu Gly Cys Cys Gly Ala Ile Lys Glu 
65                  70                  75                  80  


Ser Arg Cys Met Leu Leu Leu Phe Phe Ile Gly Leu Leu Leu Ile Leu 
                85                  90                  95      


Leu Leu Gln Val Ala Thr Gly Ile Leu Gly Ala Val Phe Lys Ser Lys 
            100                 105                 110         


Ser Asp Arg Ile Val Asn Glu Thr Leu Tyr Glu Asn Thr Lys Leu Leu 
        115                 120                 125             


Ser Ala Thr Gly Glu Ser Glu Lys Gln Phe Gln Glu Ala Ile Ile Val 
    130                 135                 140                 


Phe Gln Glu Glu Phe Lys Cys Cys Gly Leu Val Asn Gly Ala Ala Asp 
145                 150                 155                 160 


Trp Gly Asn Asn Phe Gln His Tyr Pro Glu Leu Cys Ala Cys Leu Asp 
                165                 170                 175     


Lys Gln Arg Pro Cys Gln Ser Tyr Asn Gly Lys Gln Val Tyr Lys Glu 
            180                 185                 190         


Thr Cys Ile Ser Phe Ile Lys Asp Phe Leu Ala Lys Asn Leu Ile Ile 
        195                 200                 205             


Val Ile Gly Ile Ser Phe Gly Leu Ala Val Ile Glu Ile Leu Gly Leu 
    210                 215                 220                 


Val Phe Ser Met Val Leu Tyr Cys Gln Ile Gly Asn Lys 
225                 230                 235         


<210>  3086
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  3086

Met Cys Thr Gly Gly Cys Ala Arg Cys Leu Gly Gly Thr Leu Ile Pro 
1               5                   10                  15      


Leu Ala Phe Phe Gly Phe Leu Ala Asn Ile Leu Leu Phe Phe Pro Gly 
            20                  25                  30          


Gly Lys Val Ile Asp Asp Asn Asp His Leu Ser Gln Glu Ile Trp Phe 
        35                  40                  45              


Phe Gly Gly Ile Leu Gly Ser Gly Val Leu Met Ile Phe Pro Ala Leu 
    50                  55                  60                  


Val Phe Leu Gly Leu Lys Asn Asn Asp Cys Cys Gly Cys Cys Gly Asn 
65                  70                  75                  80  


Glu Gly Cys Gly Lys Arg Phe Ala Met Phe Thr Ser Thr Ile Phe Ala 
                85                  90                  95      


Val Val Gly Phe Leu Gly Ala Gly Tyr Ser Phe Ile Ile Ser Ala Ile 
            100                 105                 110         


Ser Ile Asn Lys Gly Pro Lys Cys Leu Met Ala Asn Ser Thr Trp Gly 
        115                 120                 125             


Tyr Pro Phe His Asp Gly Asp Tyr Leu Asn Asp Glu Ala Leu Trp Asn 
    130                 135                 140                 


Lys Cys Arg Glu Pro Leu Asn Val Val Pro Trp Asn Leu Thr Leu Phe 
145                 150                 155                 160 


Ser Ile Leu Leu Val Val Gly Gly Ile Gln Met Val Leu Cys Ala Ile 
                165                 170                 175     


Gln Val Val Asn Gly Leu Leu Gly Thr Leu Cys Gly Asp Cys Gln Cys 
            180                 185                 190         


Cys Gly Cys Cys Gly Gly Asp Gly Pro Val 
        195                 200         


<210>  3087
<211>  931
<212>  PRT
<213>  Homo sapiens

<400>  3087

Met Ser Gln Ser Pro Ala Phe Gly Pro Arg Arg Gly Ser Ser Pro Arg 
1               5                   10                  15      


Gly Ala Ala Gly Ala Ala Ala Arg Arg Asn Glu Ser Gln Asp Tyr Leu 
            20                  25                  30          


Leu Met Asp Ser Glu Leu Gly Glu Asp Gly Cys Pro Gln Ala Pro Leu 
        35                  40                  45              


Pro Cys Tyr Gly Tyr Tyr Pro Cys Phe Arg Gly Ser Asp Asn Arg Leu 
    50                  55                  60                  


Ala His Arg Arg Gln Thr Val Leu Arg Glu Lys Gly Arg Arg Leu Ala 
65                  70                  75                  80  


Asn Arg Gly Pro Ala Tyr Met Phe Ser Asp Arg Ser Thr Ser Leu Ser 
                85                  90                  95      


Ile Glu Glu Glu Arg Phe Leu Asp Ala Ala Glu Tyr Gly Asn Ile Pro 
            100                 105                 110         


Val Val Arg Lys Met Leu Glu Glu Cys His Ser Leu Asn Val Asn Cys 
        115                 120                 125             


Val Asp Tyr Met Gly Gln Asn Ala Leu Gln Leu Ala Val Ala Asn Glu 
    130                 135                 140                 


His Leu Glu Ile Thr Glu Leu Leu Leu Lys Lys Glu Asn Leu Ser Arg 
145                 150                 155                 160 


Val Gly Asp Ala Leu Leu Leu Ala Ile Ser Lys Gly Tyr Val Arg Ile 
                165                 170                 175     


Val Glu Ala Ile Leu Ser His Pro Ala Phe Ala Glu Gly Lys Arg Leu 
            180                 185                 190         


Ala Thr Ser Pro Ser Gln Ser Glu Leu Gln Gln Asp Asp Phe Tyr Ala 
        195                 200                 205             


Tyr Asp Glu Asp Gly Thr Arg Phe Ser His Asp Val Thr Pro Ile Ile 
    210                 215                 220                 


Leu Ala Ala His Cys Gln Glu Tyr Glu Ile Val His Thr Leu Leu Arg 
225                 230                 235                 240 


Lys Gly Ala Arg Ile Glu Arg Pro His Asp Tyr Phe Cys Lys Cys Asn 
                245                 250                 255     


Asp Cys Asn Gln Lys Gln Lys His Asp Ser Phe Ser His Ser Arg Ser 
            260                 265                 270         


Arg Ile Asn Ala Tyr Lys Gly Leu Ala Ser Pro Ala Tyr Leu Ser Leu 
        275                 280                 285             


Ser Ser Glu Asp Pro Val Met Thr Ala Leu Glu Leu Ser Asn Glu Leu 
    290                 295                 300                 


Ala Val Leu Ala Asn Ile Glu Lys Glu Phe Lys Asn Asp Tyr Lys Lys 
305                 310                 315                 320 


Leu Ser Met Gln Cys Lys Asp Phe Val Val Gly Leu Leu Asp Leu Cys 
                325                 330                 335     


Arg Asn Thr Glu Glu Val Glu Ala Ile Leu Asn Gly Asp Val Glu Thr 
            340                 345                 350         


Leu Gln Ser Gly Asp His Gly Arg Pro Asn Leu Ser Arg Leu Lys Leu 
        355                 360                 365             


Ala Ile Lys Tyr Glu Val Lys Lys Phe Val Ala His Pro Asn Cys Gln 
    370                 375                 380                 


Gln Gln Leu Leu Ser Ile Trp Tyr Glu Asn Leu Ser Gly Leu Arg Gln 
385                 390                 395                 400 


Gln Thr Met Ala Val Lys Phe Leu Val Val Leu Ala Val Ala Ile Gly 
                405                 410                 415     


Leu Pro Phe Leu Ala Leu Ile Tyr Trp Phe Ala Pro Cys Ser Lys Met 
            420                 425                 430         


Gly Lys Ile Met Arg Gly Pro Phe Met Lys Phe Val Ala His Ala Ala 
        435                 440                 445             


Ser Phe Thr Ile Phe Leu Gly Leu Leu Val Met Asn Ala Ala Asp Arg 
    450                 455                 460                 


Phe Glu Gly Thr Lys Leu Leu Pro Asn Glu Thr Ser Thr Asp Asn Ala 
465                 470                 475                 480 


Lys Gln Leu Phe Arg Met Lys Thr Ser Cys Phe Ser Trp Met Glu Met 
                485                 490                 495     


Leu Ile Ile Ser Trp Val Ile Gly Met Ile Trp Ala Glu Cys Lys Glu 
            500                 505                 510         


Ile Trp Thr Gln Gly Pro Lys Glu Tyr Leu Phe Glu Leu Trp Asn Met 
        515                 520                 525             


Leu Asp Phe Gly Met Leu Ala Ile Phe Ala Ala Ser Phe Ile Ala Arg 
    530                 535                 540                 


Phe Met Ala Phe Trp His Ala Ser Lys Ala Gln Ser Ile Ile Asp Ala 
545                 550                 555                 560 


Asn Asp Thr Leu Lys Asp Leu Thr Lys Val Thr Leu Gly Asp Asn Val 
                565                 570                 575     


Lys Tyr Tyr Asn Leu Ala Arg Ile Lys Trp Asp Pro Ser Asp Pro Gln 
            580                 585                 590         


Ile Ile Ser Glu Gly Leu Tyr Ala Ile Ala Val Val Leu Ser Phe Ser 
        595                 600                 605             


Arg Ile Ala Tyr Ile Leu Pro Ala Asn Glu Ser Phe Gly Pro Leu Gln 
    610                 615                 620                 


Ile Ser Leu Gly Arg Thr Val Lys Asp Ile Phe Lys Phe Met Val Ile 
625                 630                 635                 640 


Phe Ile Met Val Phe Val Ala Phe Met Ile Gly Met Phe Asn Leu Tyr 
                645                 650                 655     


Ser Tyr Tyr Ile Gly Ala Lys Gln Asn Glu Ala Phe Thr Thr Val Glu 
            660                 665                 670         


Glu Ser Phe Lys Thr Leu Phe Trp Ala Ile Phe Gly Leu Ser Glu Val 
        675                 680                 685             


Lys Ser Val Val Ile Asn Tyr Asn His Lys Phe Ile Glu Asn Ile Gly 
    690                 695                 700                 


Tyr Val Leu Tyr Gly Val Tyr Asn Val Thr Met Val Ile Val Leu Leu 
705                 710                 715                 720 


Asn Met Leu Ile Ala Met Ile Asn Ser Ser Phe Gln Glu Ile Glu Asp 
                725                 730                 735     


Asp Ala Asp Val Glu Trp Lys Phe Ala Arg Ala Lys Leu Trp Phe Ser 
            740                 745                 750         


Tyr Phe Glu Glu Gly Arg Thr Leu Pro Val Pro Phe Asn Leu Val Pro 
        755                 760                 765             


Ser Pro Lys Ser Leu Phe Tyr Leu Leu Leu Lys Leu Lys Lys Trp Ile 
    770                 775                 780                 


Ser Glu Leu Phe Gln Gly His Lys Lys Gly Phe Gln Glu Asp Ala Glu 
785                 790                 795                 800 


Met Asn Lys Ile Asn Glu Glu Lys Lys Leu Gly Ile Leu Gly Ser His 
                805                 810                 815     


Glu Asp Leu Ser Lys Leu Ser Leu Asp Lys Lys Gln Val Gly His Asn 
            820                 825                 830         


Lys Gln Pro Ser Ile Arg Ser Ser Glu Asp Phe His Leu Asn Ser Phe 
        835                 840                 845             


Asn Asn Pro Pro Arg Gln Tyr Gln Lys Ile Met Lys Arg Leu Ile Lys 
    850                 855                 860                 


Arg Tyr Val Leu Gln Ala Gln Ile Asp Lys Glu Ser Asp Glu Val Asn 
865                 870                 875                 880 


Glu Gly Glu Leu Lys Glu Ile Lys Gln Asp Ile Ser Ser Leu Arg Tyr 
                885                 890                 895     


Glu Leu Leu Glu Glu Lys Ser Gln Asn Thr Glu Asp Leu Ala Glu Leu 
            900                 905                 910         


Ile Arg Glu Leu Gly Glu Lys Leu Ser Met Glu Pro Asn Gln Glu Glu 
        915                 920                 925             


Thr Asn Arg 
    930     


<210>  3088
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  3088

Met Arg Pro Pro Ser Pro Leu Pro Ala Arg Trp Leu Cys Val Leu Ala 
1               5                   10                  15      


Gly Ala Leu Ala Trp Ala Leu Gly Pro Ala Gly Gly Gln Ala Ala Arg 
            20                  25                  30          


Leu Gln Glu Glu Cys Asp Tyr Val Gln Met Ile Glu Val Gln His Lys 
        35                  40                  45              


Gln Cys Leu Glu Glu Ala Gln Leu Glu Asn Glu Thr Ile Gly Cys Ser 
    50                  55                  60                  


Lys Met Trp Asp Asn Leu Thr Cys Trp Pro Ala Thr Pro Arg Gly Gln 
65                  70                  75                  80  


Val Val Val Leu Ala Cys Pro Leu Ile Phe Lys Leu Phe Ser Ser Ile 
                85                  90                  95      


Gln Gly Arg Asn Val Ser Arg Ser Cys Thr Asp Glu Gly Trp Thr His 
            100                 105                 110         


Leu Glu Pro Gly Pro Tyr Pro Ile Ala Cys Gly Leu Asp Asp Lys Ala 
        115                 120                 125             


Ala Ser Leu Asp Glu Gln Gln Thr Met Phe Tyr Gly Ser Val Lys Thr 
    130                 135                 140                 


Gly Tyr Thr Ile Gly Tyr Gly Leu Ser Leu Ala Thr Leu Leu Val Ala 
145                 150                 155                 160 


Thr Ala Ile Leu Ser Leu Phe Arg Lys Leu His Cys Thr Arg Asn Tyr 
                165                 170                 175     


Ile His Met His Leu Phe Ile Ser Phe Ile Leu Arg Ala Ala Ala Val 
            180                 185                 190         


Phe Ile Lys Asp Leu Ala Leu Phe Asp Ser Gly Glu Ser Asp Gln Cys 
        195                 200                 205             


Ser Glu Gly Ser Val Gly Cys Lys Ala Ala Met Val Phe Phe Gln Tyr 
    210                 215                 220                 


Cys Val Met Ala Asn Phe Phe Trp Leu Leu Val Glu Gly Leu Tyr Leu 
225                 230                 235                 240 


Tyr Thr Leu Leu Ala Val Ser Phe Phe Ser Glu Arg Lys Tyr Phe Trp 
                245                 250                 255     


Gly Tyr Ile Leu Ile Gly Trp Gly Val Pro Ser Thr Phe Thr Met Val 
            260                 265                 270         


Trp Thr Ile Ala Arg Ile His Phe Glu Asp Tyr Gly Cys Trp Asp Thr 
        275                 280                 285             


Ile Asn Ser Ser Leu Trp Trp Ile Ile Lys Gly Pro Ile Leu Thr Ser 
    290                 295                 300                 


Ile Leu Val Asn Phe Ile Leu Phe Ile Cys Ile Ile Arg Ile Leu Leu 
305                 310                 315                 320 


Gln Lys Leu Arg Pro Pro Asp Ile Arg Lys Ser Asp Ser Ser Pro Tyr 
                325                 330                 335     


Ser Arg Leu Ala Arg Ser Thr Leu Leu Leu Ile Pro Leu Phe Gly Val 
            340                 345                 350         


His Tyr Ile Met Phe Ala Phe Phe Pro Asp Asn Phe Lys Pro Glu Val 
        355                 360                 365             


Lys Met Val Phe Glu Leu Val Val Gly Ser Phe Gln Gly Phe Val Val 
    370                 375                 380                 


Ala Ile Leu Tyr Cys Phe Leu Asn Gly Glu Val Gln Ala Glu Leu Arg 
385                 390                 395                 400 


Arg Lys Trp Arg Arg Trp His Leu Gln Gly Val Leu Gly Trp Asn Pro 
                405                 410                 415     


Lys Tyr Arg His Pro Ser Gly Gly Ser Asn Gly Ala Thr Cys Ser Thr 
            420                 425                 430         


Gln Val Ser Met Leu Thr Arg Val Ser Pro Gly Ala Arg Arg Ser Ser 
        435                 440                 445             


Ser Phe Gln Ala Glu Val Ser Leu Val 
    450                 455         


<210>  3089
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  3089

Met Asn Arg Lys Ala Arg Arg Cys Leu Gly His Leu Phe Leu Ser Leu 
1               5                   10                  15      


Gly Met Val Tyr Leu Arg Ile Gly Gly Phe Ser Ser Val Val Ala Leu 
            20                  25                  30          


Gly Ala Ser Ile Ile Cys Asn Lys Ile Pro Gly Leu Ala Pro Arg Gln 
        35                  40                  45              


Arg Ala Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile Gly Glu 
    50                  55                  60                  


Gly Ser Gln Met Gly Leu Asp Glu Cys Gln Phe Gln Phe Arg Asn Gly 
65                  70                  75                  80  


Arg Trp Asn Cys Ser Ala Leu Gly Glu Arg Thr Val Phe Gly Lys Glu 
                85                  90                  95      


Leu Lys Val Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Ile Ala 
            100                 105                 110         


Ala Gly Val Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn Leu 
        115                 120                 125             


Ser Asp Cys Gly Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Arg Asp 
    130                 135                 140                 


Glu Gly Trp Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile 
145                 150                 155                 160 


Gly Phe Ala Lys Val Phe Val Asp Ala Arg Glu Ile Lys Gln Asn Ala 
                165                 170                 175     


Arg Thr Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu 
            180                 185                 190         


Glu Glu Asn Met Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser 
        195                 200                 205             


Cys Thr Thr Lys Thr Cys Trp Thr Thr Leu Pro Gln Phe Arg Glu Leu 
    210                 215                 220                 


Gly Tyr Val Leu Lys Asp Lys Tyr Asn Glu Ala Val His Val Glu Pro 
225                 230                 235                 240 


Val Arg Ala Ser Arg Asn Lys Arg Pro Thr Phe Leu Lys Ile Lys Lys 
                245                 250                 255     


Pro Leu Ser Tyr Arg Lys Pro Met Asp Thr Asp Leu Val Tyr Ile Glu 
            260                 265                 270         


Lys Ser Pro Asn Tyr Cys Glu Glu Asp Pro Val Thr Gly Ser Val Gly 
        275                 280                 285             


Thr Gln Gly Arg Ala Cys Asn Lys Thr Ala Pro Gln Ala Ser Gly Cys 
    290                 295                 300                 


Asp Leu Met Cys Cys Gly Arg Gly Tyr Asn Thr His Gln Tyr Ala Arg 
305                 310                 315                 320 


Val Trp Gln Cys Asn Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys 
                325                 330                 335     


Asn Thr Cys Ser Glu Arg Thr Glu Met Tyr Thr Cys Lys 
            340                 345                 


<210>  3090
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  3090

Met Arg Ala Arg Pro Gln Val Cys Glu Ala Leu Leu Phe Ala Leu Ala 
1               5                   10                  15      


Leu Gln Thr Gly Val Cys Tyr Gly Ile Lys Trp Leu Ala Leu Ser Lys 
            20                  25                  30          


Thr Pro Ser Ala Leu Ala Leu Asn Gln Thr Gln His Cys Lys Gln Leu 
        35                  40                  45              


Glu Gly Leu Val Ser Ala Gln Val Gln Leu Cys Arg Ser Asn Leu Glu 
    50                  55                  60                  


Leu Met His Thr Val Val His Ala Ala Arg Glu Val Met Lys Ala Cys 
65                  70                  75                  80  


Arg Arg Ala Phe Ala Asp Met Arg Trp Asn Cys Ser Ser Ile Glu Leu 
                85                  90                  95      


Ala Pro Asn Tyr Leu Leu Asp Leu Glu Arg Gly Thr Arg Glu Ser Ala 
            100                 105                 110         


Phe Val Tyr Ala Leu Ser Ala Ala Ala Ile Ser His Ala Ile Ala Arg 
        115                 120                 125             


Ala Cys Thr Ser Gly Asp Leu Pro Gly Cys Ser Cys Gly Pro Val Pro 
    130                 135                 140                 


Gly Glu Pro Pro Gly Pro Gly Asn Arg Trp Gly Gly Cys Ala Asp Asn 
145                 150                 155                 160 


Leu Ser Tyr Gly Leu Leu Met Gly Ala Lys Phe Ser Asp Ala Pro Met 
                165                 170                 175     


Lys Val Lys Lys Thr Gly Ser Gln Ala Asn Lys Leu Met Arg Leu His 
            180                 185                 190         


Asn Ser Glu Val Gly Arg Gln Ala Leu Arg Ala Ser Leu Glu Met Lys 
        195                 200                 205             


Cys Lys Cys His Gly Val Ser Gly Ser Cys Ser Ile Arg Thr Cys Trp 
    210                 215                 220                 


Lys Gly Leu Gln Glu Leu Gln Asp Val Ala Ala Asp Leu Lys Thr Arg 
225                 230                 235                 240 


Tyr Leu Ser Ala Thr Lys Val Val His Arg Pro Met Gly Thr Arg Lys 
                245                 250                 255     


His Leu Val Pro Lys Asp Leu Asp Ile Arg Pro Val Lys Asp Ser Glu 
            260                 265                 270         


Leu Val Tyr Leu Gln Ser Ser Pro Asp Phe Cys Met Lys Asn Glu Lys 
        275                 280                 285             


Val Gly Ser His Gly Thr Gln Asp Arg Gln Cys Asn Lys Thr Ser Asn 
    290                 295                 300                 


Gly Ser Asp Ser Cys Asp Leu Met Cys Cys Gly Arg Gly Tyr Asn Pro 
305                 310                 315                 320 


Tyr Thr Asp Arg Val Val Glu Arg Cys His Cys Lys Tyr His Trp Cys 
                325                 330                 335     


Cys Tyr Val Thr Cys Arg Arg Cys Glu Arg Thr Val Glu Arg Tyr Val 
            340                 345                 350         


Cys Lys 
        


<210>  3091
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  3091

Met Ser Ser Ala Ala Ala Asp His Trp Ala Trp Leu Leu Val Leu Ser 
1               5                   10                  15      


Phe Val Phe Gly Cys Asn Val Leu Arg Ile Leu Leu Pro Ser Phe Ser 
            20                  25                  30          


Ser Phe Met Ser Arg Val Leu Gln Lys Asp Ala Glu Gln Glu Ser Gln 
        35                  40                  45              


Met Arg Ala Glu Ile Gln Asp Met Lys Gln Glu Leu Ser Thr Val Asn 
    50                  55                  60                  


Met Met Asp Glu Phe Ala Arg Tyr Ala Arg Leu Glu Arg Lys Ile Asn 
65                  70                  75                  80  


Lys Met Thr Asp Lys Leu Lys Thr His Val Lys Ala Arg Thr Ala Gln 
                85                  90                  95      


Leu Ala Lys Ile Lys Trp Val Ile Ser Val Ala Phe Tyr Val Leu Gln 
            100                 105                 110         


Ala Ala Leu Met Ile Ser Leu Ile Trp Lys Tyr Tyr Ser Val Pro Val 
        115                 120                 125             


Ala Val Val Pro Ser Lys Trp Ile Thr Pro Leu Asp Arg Leu Val Ala 
    130                 135                 140                 


Phe Pro Thr Arg Val Ala Gly Gly Val Gly Ile Thr Cys Trp Ile Leu 
145                 150                 155                 160 


Val Cys Asn Lys Val Val Ala Ile Val Leu His Pro Phe Ser 
                165                 170                 


<210>  3092
<211>  963
<212>  PRT
<213>  Homo sapiens

<400>  3092

Met Gly Leu Pro Glu Pro Gly Pro Leu Arg Leu Leu Ala Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Gln Leu Gln His Leu Ala Ala Ala 
            20                  25                  30          


Ala Ala Asp Pro Leu Leu Gly Gly Gln Gly Pro Ala Lys Asp Cys Glu 
        35                  40                  45              


Lys Asp Gln Phe Gln Cys Arg Asn Glu Arg Cys Ile Pro Ser Val Trp 
    50                  55                  60                  


Arg Cys Asp Glu Asp Asp Asp Cys Leu Asp His Ser Asp Glu Asp Asp 
65                  70                  75                  80  


Cys Pro Lys Lys Thr Cys Ala Asp Ser Asp Phe Thr Cys Asp Asn Gly 
                85                  90                  95      


His Cys Ile His Glu Arg Trp Lys Cys Asp Gly Glu Glu Glu Cys Pro 
            100                 105                 110         


Asp Gly Ser Asp Glu Ser Glu Ala Thr Cys Thr Lys Gln Val Cys Pro 
        115                 120                 125             


Ala Glu Lys Leu Ser Cys Gly Pro Thr Ser His Lys Cys Val Pro Ala 
    130                 135                 140                 


Ser Trp Arg Cys Asp Gly Glu Lys Asp Cys Glu Gly Gly Ala Asp Glu 
145                 150                 155                 160 


Ala Gly Cys Ala Thr Leu Cys Ala Pro His Glu Phe Gln Cys Gly Asn 
                165                 170                 175     


Arg Ser Cys Leu Ala Ala Val Phe Val Cys Asp Gly Asp Asp Asp Cys 
            180                 185                 190         


Gly Asp Gly Ser Asp Glu Arg Gly Cys Ala Asp Pro Ala Cys Gly Pro 
        195                 200                 205             


Arg Glu Phe Arg Cys Gly Gly Asp Gly Gly Gly Ala Cys Ile Pro Glu 
    210                 215                 220                 


Arg Trp Val Cys Asp Arg Gln Phe Asp Cys Glu Asp Arg Ser Asp Glu 
225                 230                 235                 240 


Ala Ala Glu Leu Cys Gly Arg Pro Gly Pro Gly Ala Thr Ser Ala Pro 
                245                 250                 255     


Ala Ala Cys Ala Thr Ala Ser Gln Phe Ala Cys Arg Ser Gly Glu Cys 
            260                 265                 270         


Val His Leu Gly Trp Arg Cys Asp Gly Asp Arg Asp Cys Lys Asp Lys 
        275                 280                 285             


Ser Asp Glu Ala Asp Cys Pro Leu Gly Thr Cys Arg Gly Asp Glu Phe 
    290                 295                 300                 


Gln Cys Gly Asp Gly Thr Cys Val Leu Ala Ile Lys His Cys Asn Gln 
305                 310                 315                 320 


Glu Gln Asp Cys Pro Asp Gly Ser Asp Glu Ala Gly Cys Leu Gln Gly 
                325                 330                 335     


Leu Asn Glu Cys Leu His Asn Asn Gly Gly Cys Ser His Ile Cys Thr 
            340                 345                 350         


Asp Leu Lys Ile Gly Phe Glu Cys Thr Cys Pro Ala Gly Phe Gln Leu 
        355                 360                 365             


Leu Asp Gln Lys Thr Cys Gly Asp Ile Asp Glu Cys Lys Asp Pro Asp 
    370                 375                 380                 


Ala Cys Ser Gln Ile Cys Val Asn Tyr Lys Gly Tyr Phe Lys Cys Glu 
385                 390                 395                 400 


Cys Tyr Pro Gly Tyr Glu Met Asp Leu Leu Thr Lys Asn Cys Lys Ala 
                405                 410                 415     


Ala Ala Gly Lys Ser Pro Ser Leu Ile Phe Thr Asn Arg His Glu Val 
            420                 425                 430         


Arg Arg Ile Asp Leu Val Lys Arg Asn Tyr Ser Arg Leu Ile Pro Met 
        435                 440                 445             


Leu Lys Asn Val Val Ala Leu Asp Val Glu Val Ala Thr Asn Arg Ile 
    450                 455                 460                 


Tyr Trp Cys Asp Leu Ser Tyr Arg Lys Ile Tyr Ser Ala Tyr Met Asp 
465                 470                 475                 480 


Lys Ala Ser Asp Pro Lys Glu Gln Glu Val Leu Ile Asp Glu Gln Leu 
                485                 490                 495     


His Ser Pro Glu Gly Leu Ala Val Asp Trp Val His Lys His Ile Tyr 
            500                 505                 510         


Trp Thr Asp Ser Gly Asn Lys Thr Ile Ser Val Ala Thr Val Asp Gly 
        515                 520                 525             


Gly Arg Arg Arg Thr Leu Phe Ser Arg Asn Leu Ser Glu Pro Arg Ala 
    530                 535                 540                 


Ile Ala Val Asp Pro Leu Arg Gly Phe Met Tyr Trp Ser Asp Trp Gly 
545                 550                 555                 560 


Asp Gln Ala Lys Ile Glu Lys Ser Gly Leu Asn Gly Val Asp Arg Gln 
                565                 570                 575     


Thr Leu Val Ser Asp Asn Ile Glu Trp Pro Asn Gly Ile Thr Leu Asp 
            580                 585                 590         


Leu Leu Ser Gln Arg Leu Tyr Trp Val Asp Ser Lys Leu His Gln Leu 
        595                 600                 605             


Ser Ser Ile Asp Phe Ser Gly Gly Asn Arg Lys Thr Leu Ile Ser Ser 
    610                 615                 620                 


Thr Asp Phe Leu Ser His Pro Phe Gly Ile Ala Val Phe Glu Asp Lys 
625                 630                 635                 640 


Val Phe Trp Thr Asp Leu Glu Asn Glu Ala Ile Phe Ser Ala Asn Arg 
                645                 650                 655     


Leu Asn Gly Leu Glu Ile Ser Ile Leu Ala Glu Asn Leu Asn Asn Pro 
            660                 665                 670         


His Asp Ile Val Ile Phe His Glu Leu Lys Gln Pro Arg Ala Pro Asp 
        675                 680                 685             


Ala Cys Glu Leu Ser Val Gln Pro Asn Gly Gly Cys Glu Tyr Leu Cys 
    690                 695                 700                 


Leu Pro Ala Pro Gln Ile Ser Ser His Ser Pro Lys Tyr Thr Cys Ala 
705                 710                 715                 720 


Cys Pro Asp Thr Met Trp Leu Gly Pro Asp Met Lys Arg Cys Tyr Arg 
                725                 730                 735     


Ala Pro Gln Ser Thr Ser Thr Thr Thr Leu Ala Ser Thr Met Thr Arg 
            740                 745                 750         


Thr Val Pro Ala Thr Thr Arg Ala Pro Gly Thr Thr Val His Arg Ser 
        755                 760                 765             


Thr Tyr Gln Asn His Ser Thr Glu Thr Pro Ser Leu Thr Ala Ala Val 
    770                 775                 780                 


Pro Ser Ser Val Ser Val Pro Arg Ala Pro Ser Ile Ser Pro Ser Thr 
785                 790                 795                 800 


Leu Ser Pro Ala Thr Ser Asn His Ser Gln His Tyr Ala Asn Glu Asp 
                805                 810                 815     


Ser Lys Met Gly Ser Thr Val Thr Ala Ala Val Ile Gly Ile Ile Val 
            820                 825                 830         


Pro Ile Val Val Ile Ala Leu Leu Cys Met Ser Gly Tyr Leu Ile Trp 
        835                 840                 845             


Arg Asn Trp Lys Arg Lys Asn Thr Lys Ser Met Asn Phe Asp Asn Pro 
    850                 855                 860                 


Val Tyr Arg Lys Thr Thr Glu Glu Glu Asp Glu Asp Glu Leu His Ile 
865                 870                 875                 880 


Gly Arg Thr Ala Gln Ile Gly His Val Tyr Pro Ala Ala Ile Ser Ser 
                885                 890                 895     


Phe Asp Arg Pro Leu Trp Ala Glu Pro Cys Leu Gly Glu Thr Arg Glu 
            900                 905                 910         


Pro Glu Asp Pro Ala Pro Ala Leu Lys Glu Leu Phe Val Leu Pro Gly 
        915                 920                 925             


Glu Pro Arg Ser Gln Leu His Gln Leu Pro Lys Asn Pro Leu Ser Glu 
    930                 935                 940                 


Leu Pro Val Val Lys Ser Lys Arg Val Ala Leu Ser Leu Glu Asp Asp 
945                 950                 955                 960 


Gly Leu Pro 
            


<210>  3093
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  3093

Met Leu Arg Leu Tyr Val Leu Val Met Gly Val Ser Ala Phe Thr Leu 
1               5                   10                  15      


Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg Gly 
            20                  25                  30          


Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala Leu 
        35                  40                  45              


Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro Arg 
    50                  55                  60                  


Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro Gly 
65                  70                  75                  80  


Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu Leu 
                85                  90                  95      


Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg Asn 
            100                 105                 110         


Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu Asn 
        115                 120                 125             


Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr Leu 
    130                 135                 140                 


Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr Arg 
145                 150                 155                 160 


Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu Leu 
                165                 170                 175     


Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His Leu 
            180                 185                 190         


Leu Val His Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys Val 
        195                 200                 205             


Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser Ile 
    210                 215                 220                 


Glu Leu Arg Ile Lys Lys Lys Lys Glu Glu Thr Ile Pro Val Ile Ile 
225                 230                 235                 240 


Ser Pro Leu Lys Thr Ile Ser Ala Ser Leu Gly Ser Arg Leu Thr Ile 
                245                 250                 255     


Pro Cys Lys Val Phe Leu Gly Thr Gly Thr Pro Leu Thr Thr Met Leu 
            260                 265                 270         


Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser Ala Tyr Pro Gly Gly 
        275                 280                 285             


Arg Val Thr Glu Gly Pro Arg Gln Glu Tyr Ser Glu Asn Asn Glu Asn 
    290                 295                 300                 


Tyr Ile Glu Val Pro Leu Ile Phe Asp Pro Val Thr Arg Glu Asp Leu 
305                 310                 315                 320 


His Met Asp Phe Lys Cys Val Val His Asn Thr Leu Ser Phe Gln Thr 
                325                 330                 335     


Leu Arg Thr Thr Val Lys Glu Ala Ser Ser Thr Phe Ser Trp Gly Ile 
            340                 345                 350         


Val Leu Ala Pro Leu Ser Leu Ala Phe Leu Val Leu Gly Gly Ile Trp 
        355                 360                 365             


Met His Arg Arg Cys Lys His Arg Thr Gly Lys Ala Asp Gly Leu Thr 
    370                 375                 380                 


Val Leu Trp Pro His His Gln Asp Phe Gln Ser Tyr Pro Lys 
385                 390                 395             


<210>  3094
<211>  749
<212>  PRT
<213>  Homo sapiens

<400>  3094

Met Gly Arg Ala Gly Ala Ala Ala Val Ile Pro Gly Leu Ala Leu Leu 
1               5                   10                  15      


Trp Ala Val Gly Leu Gly Ser Ala Ala Pro Ser Pro Pro Arg Leu Arg 
            20                  25                  30          


Leu Ser Phe Gln Glu Leu Gln Ala Trp His Gly Leu Gln Thr Phe Ser 
        35                  40                  45              


Leu Glu Arg Thr Cys Cys Tyr Gln Ala Leu Leu Val Asp Glu Glu Arg 
    50                  55                  60                  


Gly Arg Leu Phe Val Gly Ala Glu Asn His Val Ala Ser Leu Asn Leu 
65                  70                  75                  80  


Asp Asn Ile Ser Lys Arg Ala Lys Lys Leu Ala Trp Pro Ala Pro Val 
                85                  90                  95      


Glu Trp Arg Glu Glu Cys Asn Trp Ala Gly Lys Asp Ile Gly Thr Glu 
            100                 105                 110         


Cys Met Asn Phe Val Lys Leu Leu His Ala Tyr Asn Arg Thr His Leu 
        115                 120                 125             


Leu Ala Cys Gly Thr Gly Ala Phe His Pro Thr Cys Ala Phe Val Glu 
    130                 135                 140                 


Val Gly His Arg Ala Glu Glu Pro Val Leu Arg Leu Asp Pro Gly Arg 
145                 150                 155                 160 


Ile Glu Asp Gly Lys Gly Lys Ser Pro Tyr Asp Pro Arg His Arg Ala 
                165                 170                 175     


Ala Ser Val Leu Val Gly Glu Glu Leu Tyr Ser Gly Val Ala Ala Asp 
            180                 185                 190         


Leu Met Gly Arg Asp Phe Thr Ile Phe Arg Ser Leu Gly Gln Arg Pro 
        195                 200                 205             


Ser Leu Arg Thr Glu Pro His Asp Ser Arg Trp Leu Asn Glu Pro Lys 
    210                 215                 220                 


Phe Val Lys Val Phe Trp Ile Pro Glu Ser Glu Asn Pro Asp Asp Asp 
225                 230                 235                 240 


Lys Ile Tyr Phe Phe Phe Arg Glu Thr Ala Val Glu Ala Ala Pro Ala 
                245                 250                 255     


Leu Gly Arg Leu Ser Val Ser Arg Val Gly Gln Ile Cys Arg Asn Asp 
            260                 265                 270         


Val Gly Gly Gln Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys 
        275                 280                 285             


Ala Arg Leu Val Cys Ser Val Pro Gly Val Glu Gly Asp Thr His Phe 
    290                 295                 300                 


Asp Gln Leu Gln Asp Val Phe Leu Leu Ser Ser Arg Asp His Arg Thr 
305                 310                 315                 320 


Pro Leu Leu Tyr Ala Val Phe Ser Thr Ser Ser Ser Ile Phe Gln Gly 
                325                 330                 335     


Ser Ala Val Cys Val Tyr Ser Met Asn Asp Val Arg Arg Ala Phe Leu 
            340                 345                 350         


Gly Pro Phe Ala His Lys Glu Gly Pro Met His Gln Trp Val Ser Tyr 
        355                 360                 365             


Gln Gly Arg Val Pro Tyr Pro Arg Pro Gly Met Cys Pro Ser Lys Thr 
    370                 375                 380                 


Phe Gly Thr Phe Ser Ser Thr Lys Asp Phe Pro Asp Asp Val Ile Gln 
385                 390                 395                 400 


Phe Ala Arg Asn His Pro Leu Met Tyr Asn Ser Val Leu Pro Thr Gly 
                405                 410                 415     


Gly Arg Pro Leu Phe Leu Gln Val Gly Ala Asn Tyr Thr Phe Thr Gln 
            420                 425                 430         


Ile Ala Ala Asp Arg Val Ala Ala Ala Asp Gly His Tyr Asp Val Leu 
        435                 440                 445             


Phe Ile Gly Thr Asp Val Gly Thr Val Leu Lys Val Ile Ser Val Pro 
    450                 455                 460                 


Lys Gly Ser Arg Pro Ser Ala Glu Gly Leu Leu Leu Glu Glu Leu His 
465                 470                 475                 480 


Val Phe Glu Asp Ser Ala Ala Val Thr Ser Met Gln Ile Ser Ser Lys 
                485                 490                 495     


Arg His Gln Leu Tyr Val Ala Ser Arg Ser Ala Val Ala Gln Ile Ala 
            500                 505                 510         


Leu His Arg Cys Ala Ala His Gly Arg Val Cys Thr Glu Cys Cys Leu 
        515                 520                 525             


Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Val Ala Cys Thr Arg Phe 
    530                 535                 540                 


Gln Pro Ser Ala Lys Arg Arg Phe Arg Arg Gln Asp Val Arg Asn Gly 
545                 550                 555                 560 


Asp Pro Ser Thr Leu Cys Ser Gly Asp Ser Ser Arg Pro Ala Leu Leu 
                565                 570                 575     


Glu His Lys Val Phe Gly Val Glu Gly Ser Ser Ala Phe Leu Glu Cys 
            580                 585                 590         


Glu Pro Arg Ser Leu Gln Ala Arg Val Glu Trp Thr Phe Gln Arg Ala 
        595                 600                 605             


Gly Val Thr Ala His Thr Gln Val Leu Ala Glu Glu Arg Thr Glu Arg 
    610                 615                 620                 


Thr Ala Arg Gly Leu Leu Leu Arg Arg Leu Arg Arg Arg Asp Ser Gly 
625                 630                 635                 640 


Val Tyr Leu Cys Ala Ala Val Glu Gln Gly Phe Thr Gln Pro Leu Arg 
                645                 650                 655     


Arg Leu Ser Leu His Val Leu Ser Ala Thr Gln Ala Glu Arg Leu Ala 
            660                 665                 670         


Arg Ala Glu Glu Ala Ala Pro Ala Ala Pro Pro Gly Pro Lys Leu Trp 
        675                 680                 685             


Tyr Arg Asp Phe Leu Gln Leu Val Glu Pro Gly Gly Gly Gly Ser Ala 
    690                 695                 700                 


Asn Ser Leu Arg Met Cys Arg Pro Gln Pro Ala Leu Gln Ser Leu Pro 
705                 710                 715                 720 


Leu Glu Ser Arg Arg Lys Gly Arg Asn Arg Arg Thr His Ala Pro Glu 
                725                 730                 735     


Pro Arg Ala Glu Arg Gly Pro Arg Ser Ala Thr His Trp 
            740                 745                 


<210>  3095
<211>  1027
<212>  PRT
<213>  Homo sapiens

<400>  3095

Met Val Ser Ser Asp Arg Pro Val Ser Leu Glu Asp Glu Val Ser His 
1               5                   10                  15      


Ser Met Lys Glu Met Ile Gly Gly Cys Cys Val Cys Ser Asp Glu Arg 
            20                  25                  30          


Gly Trp Ala Glu Asn Pro Leu Val Tyr Cys Asp Gly His Gly Cys Ser 
        35                  40                  45              


Val Ala Val His Gln Ala Cys Tyr Gly Ile Val Gln Val Pro Thr Gly 
    50                  55                  60                  


Pro Trp Phe Cys Arg Lys Cys Glu Ser Gln Glu Arg Ala Ala Arg Val 
65                  70                  75                  80  


Arg Cys Glu Leu Cys Pro His Lys Asp Gly Ala Leu Lys Arg Thr Asp 
                85                  90                  95      


Asn Gly Gly Trp Ala His Val Val Cys Ala Leu Tyr Ile Pro Glu Val 
            100                 105                 110         


Gln Phe Ala Asn Val Ser Thr Met Glu Pro Ile Val Leu Gln Ser Val 
        115                 120                 125             


Pro His Asp Arg Tyr Asn Lys Thr Cys Tyr Ile Cys Asp Glu Gln Gly 
    130                 135                 140                 


Arg Glu Ser Lys Ala Ala Thr Gly Ala Cys Met Thr Cys Asn Lys His 
145                 150                 155                 160 


Gly Cys Arg Gln Ala Phe His Val Thr Cys Ala Gln Phe Ala Gly Leu 
                165                 170                 175     


Leu Cys Glu Glu Glu Gly Asn Gly Ala Asp Asn Val Gln Tyr Cys Gly 
            180                 185                 190         


Tyr Cys Lys Tyr His Phe Ser Lys Leu Lys Lys Ser Lys Arg Gly Ser 
        195                 200                 205             


Asn Arg Ser Tyr Asp Gln Ser Leu Ser Asp Ser Ser Ser His Ser Gln 
    210                 215                 220                 


Asp Lys His His Glu Lys Glu Lys Lys Lys Tyr Lys Glu Lys Asp Lys 
225                 230                 235                 240 


His Lys Gln Lys His Lys Lys Gln Pro Glu Pro Ser Pro Ala Leu Val 
                245                 250                 255     


Pro Ser Leu Thr Val Thr Thr Glu Lys Thr Tyr Thr Ser Thr Ser Asn 
            260                 265                 270         


Asn Ser Ile Ser Gly Ser Leu Lys Arg Leu Glu Asp Thr Thr Ala Arg 
        275                 280                 285             


Phe Thr Asn Ala Asn Phe Gln Glu Val Ser Ala His Thr Ser Ser Gly 
    290                 295                 300                 


Lys Asp Val Ser Glu Thr Arg Gly Ser Glu Gly Lys Gly Lys Lys Ser 
305                 310                 315                 320 


Ser Ala His Ser Ser Gly Gln Arg Gly Arg Lys Pro Gly Gly Gly Arg 
                325                 330                 335     


Asn Pro Gly Thr Thr Val Ser Ala Ala Ser Pro Phe Pro Gln Gly Ser 
            340                 345                 350         


Phe Ser Gly Thr Pro Gly Ser Val Lys Ser Ser Ser Gly Ser Ser Val 
        355                 360                 365             


Gln Ser Pro Gln Asp Phe Leu Ser Phe Thr Asp Ser Asp Leu Arg Asn 
    370                 375                 380                 


Asp Ser Tyr Ser His Ser Gln Gln Ser Ser Ala Thr Lys Asp Val His 
385                 390                 395                 400 


Lys Gly Glu Ser Gly Ser Gln Glu Gly Gly Val Asn Ser Phe Ser Thr 
                405                 410                 415     


Leu Ile Gly Leu Pro Ser Thr Ser Ala Val Thr Ser Gln Pro Lys Ser 
            420                 425                 430         


Phe Glu Asn Ser Pro Gly Asp Leu Gly Asn Ser Ser Leu Pro Thr Ala 
        435                 440                 445             


Gly Tyr Lys Arg Ala Gln Thr Ser Gly Ile Glu Glu Glu Thr Val Lys 
    450                 455                 460                 


Glu Lys Lys Arg Lys Gly Asn Lys Gln Ser Lys His Gly Pro Gly Arg 
465                 470                 475                 480 


Pro Lys Gly Asn Lys Asn Gln Glu Asn Val Ser His Leu Ser Val Ser 
                485                 490                 495     


Ser Ala Ser Pro Thr Ser Ser Val Ala Ser Ala Ala Gly Ser Ile Thr 
            500                 505                 510         


Ser Ser Ser Leu Gln Lys Ser Pro Thr Leu Leu Arg Asn Gly Ser Leu 
        515                 520                 525             


Gln Ser Leu Ser Val Gly Ser Ser Pro Val Gly Ser Glu Ile Ser Met 
    530                 535                 540                 


Gln Tyr Arg His Asp Gly Ala Cys Pro Thr Thr Thr Phe Ser Glu Leu 
545                 550                 555                 560 


Leu Asn Ala Ile His Asn Asp Arg Gly Asp Ser Ser Thr Leu Thr Lys 
                565                 570                 575     


Gln Glu Leu Lys Phe Ile Gly Ile Tyr Asn Ser Asn Asp Val Ala Val 
            580                 585                 590         


Ser Phe Pro Asn Val Val Ser Gly Ser Gly Ser Ser Thr Pro Val Ser 
        595                 600                 605             


Ser Ser His Leu Pro Gln Gln Ser Ser Gly His Leu Gln Gln Val Gly 
    610                 615                 620                 


Ala Leu Ser Pro Ser Ala Val Ser Ser Ala Ala Pro Ala Val Ala Thr 
625                 630                 635                 640 


Thr Gln Ala Asn Thr Leu Ser Gly Ser Ser Leu Ser Gln Ala Pro Ser 
                645                 650                 655     


His Met Tyr Gly Asn Arg Ser Asn Ser Ser Met Ala Ala Leu Ile Ala 
            660                 665                 670         


Gln Ser Glu Asn Asn Gln Thr Asp Gln Asp Leu Gly Asp Asn Ser Arg 
        675                 680                 685             


Asn Leu Val Gly Arg Gly Ser Ser Pro Arg Gly Ser Leu Ser Pro Arg 
    690                 695                 700                 


Ser Pro Val Ser Ser Leu Gln Ile Arg Tyr Asp Gln Pro Gly Asn Ser 
705                 710                 715                 720 


Ser Leu Glu Asn Leu Pro Pro Val Ala Ala Ser Ile Glu Gln Leu Leu 
                725                 730                 735     


Glu Arg Gln Trp Ser Glu Gly Gln Gln Phe Leu Leu Glu Gln Gly Thr 
            740                 745                 750         


Pro Ser Asp Ile Leu Gly Met Leu Lys Ser Leu His Gln Leu Gln Val 
        755                 760                 765             


Glu Asn Arg Arg Leu Glu Glu Gln Ile Lys Asn Leu Thr Ala Lys Lys 
    770                 775                 780                 


Glu Arg Leu Gln Leu Leu Asn Ala Gln Leu Ser Val Pro Phe Pro Thr 
785                 790                 795                 800 


Ile Thr Ala Asn Pro Ser Pro Ser His Gln Ile His Thr Phe Ser Ala 
                805                 810                 815     


Gln Thr Ala Pro Thr Thr Asp Ser Leu Asn Ser Ser Lys Ser Pro His 
            820                 825                 830         


Ile Gly Asn Ser Phe Leu Pro Asp Asn Ser Leu Pro Val Leu Asn Gln 
        835                 840                 845             


Asp Leu Thr Ser Ser Gly Gln Ser Thr Ser Ser Ser Ser Ala Leu Ser 
    850                 855                 860                 


Thr Pro Pro Pro Ala Gly Gln Ser Pro Ala Gln Gln Gly Ser Gly Val 
865                 870                 875                 880 


Ser Gly Val Gln Gln Val Asn Gly Val Thr Val Gly Ala Leu Ala Ser 
                885                 890                 895     


Gly Met Gln Pro Val Thr Ser Thr Ile Pro Ala Val Ser Ala Val Gly 
            900                 905                 910         


Gly Ile Ile Gly Ala Leu Pro Gly Asn Gln Leu Ala Ile Asn Gly Ile 
        915                 920                 925             


Val Gly Ala Leu Asn Gly Val Met Gln Thr Pro Val Thr Met Ser Gln 
    930                 935                 940                 


Asn Pro Thr Pro Leu Thr His Thr Thr Val Pro Pro Asn Ala Thr His 
945                 950                 955                 960 


Pro Met Pro Ala Thr Leu Thr Asn Ser Ala Ser Gly Leu Gly Leu Leu 
                965                 970                 975     


Ser Asp Gln Gln Arg Gln Ile Leu Ile His Gln Gln Gln Phe Gln Gln 
            980                 985                 990         


Leu Leu Asn Ser Gln Gln Leu Thr  Pro Val His Arg His  Pro His Phe 
        995                 1000                 1005             


Thr Gln  Leu Pro Pro Thr His  Phe Ser Pro Ser Met  Glu Ile Met 
    1010                 1015                 1020             


Gln Val  Arg Lys 
    1025         


<210>  3096
<211>  1241
<212>  PRT
<213>  Homo sapiens

<400>  3096

Met Ala Leu Gly Thr Thr Leu Arg Ala Ser Leu Leu Leu Leu Gly Leu 
1               5                   10                  15      


Leu Thr Glu Gly Leu Ala Gln Leu Ala Ile Pro Ala Ser Val Pro Arg 
            20                  25                  30          


Gly Phe Trp Ala Leu Pro Glu Asn Leu Thr Val Val Glu Gly Ala Ser 
        35                  40                  45              


Val Glu Leu Arg Cys Gly Val Ser Thr Pro Gly Ser Ala Val Gln Trp 
    50                  55                  60                  


Ala Lys Asp Gly Leu Leu Leu Gly Pro Asp Pro Arg Ile Pro Gly Phe 
65                  70                  75                  80  


Pro Arg Tyr Arg Leu Glu Gly Asp Pro Ala Arg Gly Glu Phe His Leu 
                85                  90                  95      


His Ile Glu Ala Cys Asp Leu Ser Asp Asp Ala Glu Tyr Glu Cys Gln 
            100                 105                 110         


Val Gly Arg Ser Glu Met Gly Pro Glu Leu Val Ser Pro Arg Val Ile 
        115                 120                 125             


Leu Ser Ile Leu Val Pro Pro Lys Leu Leu Leu Leu Thr Pro Glu Ala 
    130                 135                 140                 


Gly Thr Met Val Thr Trp Val Ala Gly Gln Glu Tyr Val Val Asn Cys 
145                 150                 155                 160 


Val Ser Gly Asp Ala Lys Pro Ala Pro Asp Ile Thr Ile Leu Leu Ser 
                165                 170                 175     


Gly Gln Thr Ile Ser Asp Ile Ser Ala Asn Val Asn Glu Gly Ser Gln 
            180                 185                 190         


Gln Lys Leu Phe Thr Val Glu Ala Thr Ala Arg Val Thr Pro Arg Ser 
        195                 200                 205             


Ser Asp Asn Arg Gln Leu Leu Val Cys Glu Ala Ser Ser Pro Ala Leu 
    210                 215                 220                 


Glu Ala Pro Ile Lys Ala Ser Phe Thr Val Asn Val Leu Phe Pro Pro 
225                 230                 235                 240 


Gly Pro Pro Val Ile Glu Trp Pro Gly Leu Asp Glu Gly His Val Arg 
                245                 250                 255     


Ala Gly Gln Ser Leu Glu Leu Pro Cys Val Ala Arg Gly Gly Asn Pro 
            260                 265                 270         


Leu Ala Thr Leu Gln Trp Leu Lys Asn Gly Gln Pro Val Ser Thr Ala 
        275                 280                 285             


Trp Gly Thr Glu His Thr Gln Ala Val Ala Arg Ser Val Leu Val Met 
    290                 295                 300                 


Thr Val Arg Pro Glu Asp His Gly Ala Gln Leu Ser Cys Glu Ala His 
305                 310                 315                 320 


Asn Ser Val Ser Ala Gly Thr Gln Glu His Gly Ile Thr Leu Gln Val 
                325                 330                 335     


Thr Phe Pro Pro Ser Ala Ile Ile Ile Leu Gly Ser Ala Ser Gln Thr 
            340                 345                 350         


Glu Asn Lys Asn Val Thr Leu Ser Cys Val Ser Lys Ser Ser Arg Pro 
        355                 360                 365             


Arg Val Leu Leu Arg Trp Trp Leu Gly Trp Arg Gln Leu Leu Pro Met 
    370                 375                 380                 


Glu Glu Thr Val Met Asp Gly Leu His Gly Gly His Ile Ser Met Ser 
385                 390                 395                 400 


Asn Leu Thr Phe Leu Ala Arg Arg Glu Asp Asn Gly Leu Thr Leu Thr 
                405                 410                 415     


Cys Glu Ala Phe Ser Glu Ala Phe Thr Lys Glu Thr Phe Lys Lys Ser 
            420                 425                 430         


Leu Ile Leu Asn Val Lys Tyr Pro Ala Gln Lys Leu Trp Ile Glu Gly 
        435                 440                 445             


Pro Pro Glu Gly Gln Lys Leu Arg Ala Gly Thr Arg Val Arg Leu Val 
    450                 455                 460                 


Cys Leu Ala Ile Gly Gly Asn Pro Glu Pro Ser Leu Met Trp Tyr Lys 
465                 470                 475                 480 


Asp Ser Arg Thr Val Thr Glu Ser Arg Leu Pro Gln Glu Ser Arg Arg 
                485                 490                 495     


Val His Leu Gly Ser Val Glu Lys Ser Gly Ser Thr Phe Ser Arg Glu 
            500                 505                 510         


Leu Val Leu Val Thr Gly Pro Ser Asp Asn Gln Ala Lys Phe Thr Cys 
        515                 520                 525             


Lys Ala Gly Gln Leu Ser Ala Ser Thr Gln Leu Ala Val Gln Phe Pro 
    530                 535                 540                 


Pro Thr Asn Val Thr Ile Leu Ala Asn Ala Ser Ala Leu Arg Pro Gly 
545                 550                 555                 560 


Asp Ala Leu Asn Leu Thr Cys Val Ser Val Ser Ser Asn Pro Pro Val 
                565                 570                 575     


Asn Leu Ser Trp Asp Lys Glu Gly Glu Arg Leu Glu Gly Val Ala Ala 
            580                 585                 590         


Pro Pro Arg Arg Ala Pro Phe Lys Gly Ser Ala Ala Ala Arg Ser Val 
        595                 600                 605             


Leu Leu Gln Val Ser Ser Arg Asp His Gly Gln Arg Val Thr Cys Arg 
    610                 615                 620                 


Ala His Ser Ala Glu Leu Arg Glu Thr Val Ser Ser Phe Tyr Arg Leu 
625                 630                 635                 640 


Asn Val Leu Tyr Arg Pro Glu Phe Leu Gly Glu Gln Val Leu Val Val 
                645                 650                 655     


Thr Ala Val Glu Gln Gly Glu Ala Leu Leu Pro Val Ser Val Ser Ala 
            660                 665                 670         


Asn Pro Ala Pro Glu Ala Phe Asn Trp Thr Phe Arg Gly Tyr Arg Leu 
        675                 680                 685             


Ser Pro Ala Gly Gly Pro Arg His Arg Ile Leu Ser Ser Gly Ala Leu 
    690                 695                 700                 


His Leu Trp Asn Val Thr Arg Ala Asp Asp Gly Leu Tyr Gln Leu His 
705                 710                 715                 720 


Cys Gln Asn Ser Glu Gly Thr Ala Glu Ala Arg Leu Arg Leu Asp Val 
                725                 730                 735     


His Tyr Ala Pro Thr Ile Arg Ala Leu Gln Asp Pro Thr Glu Val Asn 
            740                 745                 750         


Val Gly Gly Ser Val Asp Ile Val Cys Thr Val Asp Ala Asn Pro Ile 
        755                 760                 765             


Leu Pro Gly Met Phe Asn Trp Glu Arg Leu Gly Glu Asp Glu Glu Asp 
    770                 775                 780                 


Gln Ser Leu Asp Asp Met Glu Lys Ile Ser Arg Gly Pro Thr Gly Arg 
785                 790                 795                 800 


Leu Arg Ile His His Ala Lys Leu Ala Gln Ala Gly Ala Tyr Gln Cys 
                805                 810                 815     


Ile Val Asp Asn Gly Val Ala Pro Pro Ala Arg Arg Leu Leu Arg Leu 
            820                 825                 830         


Val Val Arg Phe Ala Pro Gln Val Glu His Pro Thr Pro Leu Thr Lys 
        835                 840                 845             


Val Ala Ala Ala Gly Asp Ser Thr Ser Ser Ala Thr Leu His Cys Arg 
    850                 855                 860                 


Ala Arg Gly Val Pro Asn Ile Val Phe Thr Trp Thr Lys Asn Gly Val 
865                 870                 875                 880 


Pro Leu Asp Leu Gln Asp Pro Arg Tyr Thr Glu His Thr Tyr His Gln 
                885                 890                 895     


Gly Gly Val His Ser Ser Leu Leu Thr Ile Ala Asn Val Ser Ala Ala 
            900                 905                 910         


Gln Asp Tyr Ala Leu Phe Thr Cys Thr Ala Thr Asn Ala Leu Gly Ser 
        915                 920                 925             


Asp Gln Thr Asn Ile Gln Leu Val Ser Ile Ser Arg Pro Asp Pro Pro 
    930                 935                 940                 


Ser Gly Leu Lys Val Val Ser Leu Thr Pro His Ser Val Gly Leu Glu 
945                 950                 955                 960 


Trp Lys Pro Gly Phe Asp Gly Gly Leu Pro Gln Arg Phe Cys Ile Arg 
                965                 970                 975     


Tyr Glu Ala Leu Gly Thr Pro Gly Phe His Tyr Val Asp Val Val Pro 
            980                 985                 990         


Pro Gln Ala Thr Thr Phe Thr Leu  Thr Gly Leu Gln Pro  Ser Thr Arg 
        995                 1000                 1005             


Tyr Arg  Val Trp Leu Leu Ala  Ser Asn Ala Leu Gly  Asp Ser Gly 
    1010                 1015                 1020             


Leu Ala  Asp Lys Gly Thr Gln  Leu Pro Ile Thr Thr  Pro Gly Leu 
    1025                 1030                 1035             


His Gln  Pro Ser Gly Glu Pro  Glu Asp Gln Leu Pro  Thr Glu Pro 
    1040                 1045                 1050             


Pro Ser  Gly Pro Ser Gly Leu  Pro Leu Leu Pro Val  Leu Phe Ala 
    1055                 1060                 1065             


Leu Gly  Gly Leu Leu Leu Leu  Ser Asn Ala Ser Cys  Val Gly Gly 
    1070                 1075                 1080             


Val Leu  Trp Gln Arg Arg Leu  Arg Arg Leu Ala Glu  Gly Ile Ser 
    1085                 1090                 1095             


Glu Lys  Thr Glu Ala Gly Ser  Glu Glu Asp Arg Val  Arg Asn Glu 
    1100                 1105                 1110             


Tyr Glu  Glu Ser Gln Trp Thr  Gly Glu Arg Asp Thr  Gln Ser Ser 
    1115                 1120                 1125             


Thr Val  Ser Thr Thr Glu Ala  Glu Pro Tyr Tyr Arg  Ser Leu Arg 
    1130                 1135                 1140             


Asp Phe  Ser Pro Gln Leu Pro  Pro Thr Gln Glu Glu  Val Ser Tyr 
    1145                 1150                 1155             


Ser Arg  Gly Phe Thr Gly Glu  Asp Glu Asp Met Ala  Phe Pro Gly 
    1160                 1165                 1170             


His Leu  Tyr Asp Glu Val Glu  Arg Thr Tyr Pro Pro  Ser Gly Ala 
    1175                 1180                 1185             


Trp Gly  Pro Leu Tyr Asp Glu  Val Gln Met Gly Pro  Trp Asp Leu 
    1190                 1195                 1200             


His Trp  Pro Glu Asp Thr Tyr  Gln Asp Pro Arg Gly  Ile Tyr Asp 
    1205                 1210                 1215             


Gln Val  Ala Gly Asp Leu Asp  Thr Leu Glu Pro Asp  Ser Leu Pro 
    1220                 1225                 1230             


Phe Glu  Leu Arg Gly His Leu  Val 
    1235                 1240     


<210>  3097
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  3097

Met Lys His Ile Asn Leu Ser Phe Ala Ala Cys Gly Phe Leu Gly Ile 
1               5                   10                  15      


Tyr His Leu Gly Ala Ala Ser Ala Leu Cys Arg His Gly Lys Lys Leu 
            20                  25                  30          


Val Lys Asp Val Lys Ala Phe Ala Gly Ala Ser Ala Gly Ser Leu Val 
        35                  40                  45              


Ala Ser Val Leu Leu Thr Ala Pro Glu Lys Ile Glu Glu Cys Asn Gln 
    50                  55                  60                  


Phe Thr Tyr Lys Phe Ala Glu Glu Ile Arg Arg Gln Ser Phe Gly Ala 
65                  70                  75                  80  


Val Thr Pro Gly Tyr Asp Phe Met Ala Arg Leu Arg Ser Gly Met Glu 
                85                  90                  95      


Ser Ile Leu Pro Pro Ser Ala His Glu Leu Ala Gln Asn Arg Leu His 
            100                 105                 110         


Val Ser Ile Thr Asn Ala Lys Thr Arg Glu Asn His Leu Val Ser Thr 
        115                 120                 125             


Phe Ser Ser Arg Glu Asp Leu Ile Lys Val Leu Leu Ala Ser Ser Phe 
    130                 135                 140                 


Val Pro Ile Tyr Ala Gly Leu Lys Leu Val Glu Tyr Lys Gly Gln Lys 
145                 150                 155                 160 


Trp Val Asp Gly Gly Leu Thr Asn Ala Leu Pro Ile Leu Pro Val Gly 
                165                 170                 175     


Arg Thr Val Thr Ile Ser Pro Phe Ser Gly Arg Leu Asp Ile Ser Pro 
            180                 185                 190         


Gln Asp Lys Gly Gln Leu Asp Leu Tyr Val Asn Ile Ala Lys Gln Asp 
        195                 200                 205             


Ile Met Leu Ser Leu Ala Asn Leu Val Arg Leu Asn Gln Ala Leu Phe 
    210                 215                 220                 


Pro Pro Ser Lys Arg Lys Met Glu Ser Leu Tyr Gln Cys Gly Phe Asp 
225                 230                 235                 240 


Asp Thr Val Lys Phe Leu Leu Lys Glu Asn Trp Phe Glu 
                245                 250             


<210>  3098
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  3098

Met Val Thr Ser Ser Phe Pro Ile Ser Val Ala Val Phe Ala Leu Ile 
1               5                   10                  15      


Thr Leu Gln Val Gly Thr Gln Asp Ser Phe Ile Ala Ala Val Tyr Glu 
            20                  25                  30          


His Ala Val Ile Leu Pro Asn Lys Thr Glu Thr Pro Val Ser Gln Glu 
        35                  40                  45              


Asp Ala Leu Asn Leu Met Asn Glu Asn Ile Asp Ile Leu Glu Thr Ala 
    50                  55                  60                  


Ile Lys Gln Ala Ala Glu Gln Gly Ala Arg Ile Ile Val Thr Pro Glu 
65                  70                  75                  80  


Asp Ala Leu Tyr Gly Trp Lys Phe Thr Arg Glu Thr Val Phe Pro Tyr 
                85                  90                  95      


Leu Glu Asp Ile Pro Asp Pro Gln Val Asn Trp Ile Pro Cys Gln Asp 
            100                 105                 110         


Pro His Arg Phe Gly His Thr Pro Val Gln Ala Arg Leu Ser Cys Leu 
        115                 120                 125             


Ala Lys Asp Asn Ser Ile Tyr Val Leu Ala Asn Leu Gly Asp Lys Lys 
    130                 135                 140                 


Pro Cys Asn Ser Arg Asp Ser Thr Cys Pro Pro Asn Gly Tyr Phe Gln 
145                 150                 155                 160 


Tyr Asn Thr Asn Val Val Tyr Asn Thr Glu Gly Lys Leu Val Ala Arg 
                165                 170                 175     


Tyr His Lys Tyr His Leu Tyr Ser Glu Pro Gln Phe Asn Val Pro Glu 
            180                 185                 190         


Lys Pro Glu Leu Val Thr Phe Asn Thr Ala Phe Gly Arg Phe Gly Ile 
        195                 200                 205             


Phe Thr Cys Phe Asp Ile Phe Phe Tyr Asp Pro Gly Val Thr Leu Val 
    210                 215                 220                 


Lys Asp Phe His Val Asp Thr Ile Leu Phe Pro Thr Ala Trp Met Asn 
225                 230                 235                 240 


Val Leu Pro Leu Leu Thr Ala Ile Glu Phe His Ser Ala Trp Ala Met 
                245                 250                 255     


Gly Met Gly Val Asn Leu Leu Val Ala Asn Thr His His Val Ser Leu 
            260                 265                 270         


Asn Met Thr Gly Ser Gly Ile Tyr Ala Pro Asn Gly Pro Lys Val Tyr 
        275                 280                 285             


His Tyr Asp Met Lys Thr Glu Leu Gly Lys Leu Leu Leu Ser Glu Val 
    290                 295                 300                 


Asp Ser His Pro Leu Ser Ser Leu Ala Tyr Pro Thr Ala Val Asn Trp 
305                 310                 315                 320 


Asn Ala Tyr Ala Thr Thr Ile Lys Pro Phe Pro Val Gln Lys Asn Thr 
                325                 330                 335     


Phe Arg Gly Phe Ile Ser Arg Asp Gly Phe Asn Phe Thr Glu Leu Phe 
            340                 345                 350         


Glu Asn Ala Gly Asn Leu Thr Val Cys Gln Lys Glu Leu Cys Cys His 
        355                 360                 365             


Leu Ser Tyr Arg Met Leu Gln Lys Glu Glu Asn Glu Val Tyr Val Leu 
    370                 375                 380                 


Gly Ala Phe Thr Gly Leu His Gly Arg Arg Arg Arg Glu Tyr Trp Gln 
385                 390                 395                 400 


Val Cys Thr Met Leu Lys Cys Lys Thr Thr Asn Leu Thr Thr Cys Gly 
                405                 410                 415     


Arg Pro Val Glu Thr Ala Ser Thr Arg Phe Glu Met Phe Ser Leu Ser 
            420                 425                 430         


Gly Thr Phe Gly Thr Glu Tyr Val Phe Pro Glu Val Leu Leu Thr Glu 
        435                 440                 445             


Ile His Leu Ser Pro Gly Lys Phe Glu Val Leu Lys Asp Gly Arg Leu 
    450                 455                 460                 


Val Asn Lys Asn Gly Ser Ser Gly Pro Ile Leu Thr Val Ser Leu Phe 
465                 470                 475                 480 


Gly Arg Trp Tyr Thr Lys Asp Ser Leu Tyr Ser Ser Cys Gly Thr Ser 
                485                 490                 495     


Asn Ser Ala Ile Thr Tyr Leu Leu Ile Phe Ile Leu Leu Met Ile Ile 
            500                 505                 510         


Ala Leu Gln Asn Ile Val Met Leu 
        515                 520 


<210>  3099
<211>  1857
<212>  PRT
<213>  Homo sapiens

<400>  3099

Met Ala Arg Lys Lys Leu Lys Lys Phe Thr Thr Leu Glu Ile Val Leu 
1               5                   10                  15      


Ser Val Leu Leu Leu Val Leu Phe Ile Ile Ser Ile Val Leu Ile Val 
            20                  25                  30          


Leu Leu Ala Lys Glu Ser Leu Lys Ser Thr Ala Pro Asp Pro Gly Thr 
        35                  40                  45              


Thr Gly Thr Pro Asp Pro Gly Thr Thr Gly Thr Pro Asp Pro Gly Thr 
    50                  55                  60                  


Thr Gly Thr Thr His Ala Arg Thr Thr Gly Pro Pro Asp Pro Gly Thr 
65                  70                  75                  80  


Thr Gly Thr Thr Pro Val Ser Ala Glu Cys Pro Val Val Asn Glu Leu 
                85                  90                  95      


Glu Arg Ile Asn Cys Ile Pro Asp Gln Pro Pro Thr Lys Ala Thr Cys 
            100                 105                 110         


Asp Gln Arg Gly Cys Cys Trp Asn Pro Gln Gly Ala Val Ser Val Pro 
        115                 120                 125             


Trp Cys Tyr Tyr Ser Lys Asn His Ser Tyr His Val Glu Gly Asn Leu 
    130                 135                 140                 


Val Asn Thr Asn Ala Gly Phe Thr Ala Arg Leu Lys Asn Leu Pro Ser 
145                 150                 155                 160 


Ser Pro Val Phe Gly Ser Asn Val Asp Asn Val Leu Leu Thr Ala Glu 
                165                 170                 175     


Tyr Gln Thr Ser Asn Arg Phe His Phe Lys Leu Thr Asp Gln Thr Asn 
            180                 185                 190         


Asn Arg Phe Glu Val Pro His Glu His Val Gln Ser Phe Ser Gly Asn 
        195                 200                 205             


Ala Ala Ala Ser Leu Thr Tyr Gln Val Glu Ile Ser Arg Gln Pro Phe 
    210                 215                 220                 


Ser Ile Lys Val Thr Arg Arg Ser Asn Asn Arg Val Leu Phe Asp Ser 
225                 230                 235                 240 


Ser Ile Gly Pro Leu Leu Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr 
                245                 250                 255     


Arg Leu Pro Ser Thr Asn Val Tyr Gly Leu Gly Glu His Val His Gln 
            260                 265                 270         


Gln Tyr Arg His Asp Met Asn Trp Lys Thr Trp Pro Ile Phe Asn Arg 
        275                 280                 285             


Asp Thr Thr Pro Asn Gly Asn Gly Thr Asn Leu Tyr Gly Ala Gln Thr 
    290                 295                 300                 


Phe Phe Leu Cys Leu Glu Asp Ala Ser Gly Leu Ser Phe Gly Val Phe 
305                 310                 315                 320 


Leu Met Asn Ser Asn Ala Met Glu Val Val Leu Gln Pro Ala Pro Ala 
                325                 330                 335     


Ile Thr Tyr Arg Thr Ile Gly Gly Ile Leu Asp Phe Tyr Val Phe Leu 
            340                 345                 350         


Gly Asn Thr Pro Glu Gln Val Val Gln Glu Tyr Leu Glu Leu Ile Gly 
        355                 360                 365             


Arg Pro Ala Leu Pro Ser Tyr Trp Ala Leu Gly Phe His Leu Ser Arg 
    370                 375                 380                 


Tyr Glu Tyr Gly Thr Leu Asp Asn Met Arg Glu Val Val Glu Arg Asn 
385                 390                 395                 400 


Arg Ala Ala Gln Leu Pro Tyr Asp Val Gln His Ala Asp Ile Asp Tyr 
                405                 410                 415     


Met Asp Glu Arg Arg Asp Phe Thr Tyr Asp Ser Val Asp Phe Lys Gly 
            420                 425                 430         


Phe Pro Glu Phe Val Asn Glu Leu His Asn Asn Gly Gln Lys Leu Val 
        435                 440                 445             


Ile Ile Val Asp Pro Ala Ile Ser Asn Asn Ser Ser Ser Ser Lys Pro 
    450                 455                 460                 


Tyr Gly Pro Tyr Asp Arg Gly Ser Asp Met Lys Ile Trp Val Asn Ser 
465                 470                 475                 480 


Ser Asp Gly Val Thr Pro Leu Ile Gly Glu Val Trp Pro Gly Gln Thr 
                485                 490                 495     


Val Phe Pro Asp Tyr Thr Asn Pro Asn Cys Ala Val Trp Trp Thr Lys 
            500                 505                 510         


Glu Phe Glu Leu Phe His Asn Gln Val Glu Phe Asp Gly Ile Trp Ile 
        515                 520                 525             


Asp Met Asn Glu Val Ser Asn Phe Val Asp Gly Ser Val Ser Gly Cys 
    530                 535                 540                 


Ser Thr Asn Asn Leu Asn Asn Pro Pro Phe Thr Pro Arg Ile Leu Asp 
545                 550                 555                 560 


Gly Tyr Leu Phe Cys Lys Thr Leu Cys Met Asp Ala Val Gln His Trp 
                565                 570                 575     


Gly Lys Gln Tyr Asp Ile His Asn Leu Tyr Gly Tyr Ser Met Ala Val 
            580                 585                 590         


Ala Thr Ala Glu Ala Ala Lys Thr Val Phe Pro Asn Lys Arg Ser Phe 
        595                 600                 605             


Ile Leu Thr Arg Ser Thr Phe Ala Gly Ser Gly Lys Phe Ala Ala His 
    610                 615                 620                 


Trp Leu Gly Asp Asn Thr Ala Thr Trp Asp Asp Leu Arg Trp Ser Ile 
625                 630                 635                 640 


Pro Gly Val Leu Glu Phe Asn Leu Phe Gly Ile Pro Met Val Gly Pro 
                645                 650                 655     


Asp Ile Cys Gly Phe Ala Leu Asp Thr Pro Glu Glu Leu Cys Arg Arg 
            660                 665                 670         


Trp Met Gln Leu Gly Ala Phe Tyr Pro Phe Ser Arg Asn His Asn Gly 
        675                 680                 685             


Gln Gly Tyr Lys Asp Gln Asp Pro Ala Ser Phe Gly Ala Asp Ser Leu 
    690                 695                 700                 


Leu Leu Asn Ser Ser Arg His Tyr Leu Asn Ile Arg Tyr Thr Leu Leu 
705                 710                 715                 720 


Pro Tyr Leu Tyr Thr Leu Phe Phe Arg Ala His Ser Arg Gly Asp Thr 
                725                 730                 735     


Val Ala Arg Pro Leu Leu His Glu Phe Tyr Glu Asp Asn Ser Thr Trp 
            740                 745                 750         


Asp Val His Gln Gln Phe Leu Trp Gly Pro Gly Leu Leu Ile Thr Pro 
        755                 760                 765             


Val Leu Asp Glu Gly Ala Glu Lys Val Met Ala Tyr Val Pro Asp Ala 
    770                 775                 780                 


Val Trp Tyr Asp Tyr Glu Thr Gly Ser Gln Val Arg Trp Arg Lys Gln 
785                 790                 795                 800 


Lys Val Glu Met Glu Leu Pro Gly Asp Lys Ile Gly Leu His Leu Arg 
                805                 810                 815     


Gly Gly Tyr Ile Phe Pro Thr Gln Gln Pro Asn Thr Thr Thr Leu Ala 
            820                 825                 830         


Ser Arg Lys Asn Pro Leu Gly Leu Ile Ile Ala Leu Asp Glu Asn Lys 
        835                 840                 845             


Glu Ala Lys Gly Glu Leu Phe Trp Asp Asn Gly Glu Thr Lys Asp Thr 
    850                 855                 860                 


Val Ala Asn Lys Val Tyr Leu Leu Cys Glu Phe Ser Val Thr Gln Asn 
865                 870                 875                 880 


Arg Leu Glu Val Asn Ile Ser Gln Ser Thr Tyr Lys Asp Pro Asn Asn 
                885                 890                 895     


Leu Ala Phe Asn Glu Ile Lys Ile Leu Gly Thr Glu Glu Pro Ser Asn 
            900                 905                 910         


Val Thr Val Lys His Asn Gly Val Pro Ser Gln Thr Ser Pro Thr Val 
        915                 920                 925             


Thr Tyr Asp Ser Asn Leu Lys Val Ala Ile Ile Thr Asp Ile Asp Leu 
    930                 935                 940                 


Leu Leu Gly Glu Ala Tyr Thr Val Glu Trp Ser Ile Lys Ile Arg Asp 
945                 950                 955                 960 


Glu Glu Lys Ile Asp Cys Tyr Pro Asp Glu Asn Gly Ala Ser Ala Glu 
                965                 970                 975     


Asn Cys Thr Ala Arg Gly Cys Ile Trp Glu Ala Ser Asn Ser Ser Gly 
            980                 985                 990         


Val Pro Phe Cys Tyr Phe Val Asn  Asp Leu Tyr Ser Val  Ser Asp Val 
        995                 1000                 1005             


Gln Tyr  Asn Ser His Gly Ala  Thr Ala Asp Ile Ser  Leu Lys Ser 
    1010                 1015                 1020             


Ser Val  Tyr Ala Asn Ala Phe  Pro Ser Thr Pro Val  Asn Pro Leu 
    1025                 1030                 1035             


Arg Leu  Asp Val Thr Tyr His  Lys Asn Glu Met Leu  Gln Phe Lys 
    1040                 1045                 1050             


Ile Tyr  Asp Pro Asn Lys Asn  Arg Tyr Glu Val Pro  Val Pro Leu 
    1055                 1060                 1065             


Asn Ile  Pro Ser Met Pro Ser  Ser Thr Pro Glu Gly  Gln Leu Tyr 
    1070                 1075                 1080             


Asp Val  Leu Ile Lys Lys Asn  Pro Phe Gly Ile Glu  Ile Arg Arg 
    1085                 1090                 1095             


Lys Ser  Thr Gly Thr Ile Ile  Trp Asp Ser Gln Leu  Leu Gly Phe 
    1100                 1105                 1110             


Thr Phe  Ser Asp Met Phe Ile  Arg Ile Ser Thr Arg  Leu Pro Ser 
    1115                 1120                 1125             


Lys Tyr  Leu Tyr Gly Phe Gly  Glu Thr Glu His Arg  Ser Tyr Arg 
    1130                 1135                 1140             


Arg Asp  Leu Glu Trp His Thr  Trp Gly Met Phe Ser  Arg Asp Gln 
    1145                 1150                 1155             


Pro Pro  Gly Tyr Lys Lys Asn  Ser Tyr Gly Val His  Pro Tyr Tyr 
    1160                 1165                 1170             


Met Gly  Leu Glu Glu Asp Gly  Ser Ala His Gly Val  Leu Leu Leu 
    1175                 1180                 1185             


Asn Ser  Asn Ala Met Asp Val  Thr Phe Gln Pro Leu  Pro Ala Leu 
    1190                 1195                 1200             


Thr Tyr  Arg Thr Thr Gly Gly  Val Leu Asp Phe Tyr  Val Phe Leu 
    1205                 1210                 1215             


Gly Pro  Thr Pro Glu Leu Val  Thr Gln Gln Tyr Thr  Glu Leu Ile 
    1220                 1225                 1230             


Gly Arg  Pro Val Met Val Pro  Tyr Trp Ser Leu Gly  Phe Gln Leu 
    1235                 1240                 1245             


Cys Arg  Tyr Gly Tyr Gln Asn  Asp Ser Glu Ile Ala  Ser Leu Tyr 
    1250                 1255                 1260             


Asp Glu  Met Val Ala Ala Gln  Ile Pro Tyr Asp Val  Gln Tyr Ser 
    1265                 1270                 1275             


Asp Ile  Asp Tyr Met Glu Arg  Gln Leu Asp Phe Thr  Leu Ser Pro 
    1280                 1285                 1290             


Lys Phe  Ala Gly Phe Pro Ala  Leu Ile Asn Arg Met  Lys Ala Asp 
    1295                 1300                 1305             


Gly Met  Arg Val Ile Leu Ile  Leu Asp Pro Ala Ile  Ser Gly Asn 
    1310                 1315                 1320             


Glu Thr  Gln Pro Tyr Pro Ala  Phe Thr Arg Gly Val  Glu Asp Asp 
    1325                 1330                 1335             


Val Phe  Ile Lys Tyr Pro Asn  Asp Gly Asp Ile Val  Trp Gly Lys 
    1340                 1345                 1350             


Val Trp  Pro Asp Phe Pro Asp  Val Val Val Asn Gly  Ser Leu Asp 
    1355                 1360                 1365             


Trp Asp  Ser Gln Val Glu Leu  Tyr Arg Ala Tyr Val  Ala Phe Pro 
    1370                 1375                 1380             


Asp Phe  Phe Arg Asn Ser Thr  Ala Lys Trp Trp Lys  Arg Glu Ile 
    1385                 1390                 1395             


Glu Glu  Leu Tyr Asn Asn Pro  Gln Asn Pro Glu Arg  Ser Leu Lys 
    1400                 1405                 1410             


Phe Asp  Gly Met Trp Ile Asp  Met Asn Glu Pro Ser  Ser Phe Val 
    1415                 1420                 1425             


Asn Gly  Ala Val Ser Pro Gly  Cys Arg Asp Ala Ser  Leu Asn His 
    1430                 1435                 1440             


Pro Pro  Tyr Met Pro His Leu  Glu Ser Arg Asp Arg  Gly Leu Ser 
    1445                 1450                 1455             


Ser Lys  Thr Leu Cys Met Glu  Ser Gln Gln Ile Leu  Pro Asp Gly 
    1460                 1465                 1470             


Ser Leu  Val Gln His Tyr Asn  Val His Asn Leu Tyr  Gly Trp Ser 
    1475                 1480                 1485             


Gln Thr  Arg Pro Thr Tyr Glu  Ala Val Gln Glu Val  Thr Gly Gln 
    1490                 1495                 1500             


Arg Gly  Val Val Ile Thr Arg  Ser Thr Phe Pro Ser  Ser Gly Arg 
    1505                 1510                 1515             


Trp Ala  Gly His Trp Leu Gly  Asp Asn Thr Ala Ala  Trp Asp Gln 
    1520                 1525                 1530             


Leu Lys  Lys Ser Ile Ile Gly  Met Met Glu Phe Ser  Leu Phe Gly 
    1535                 1540                 1545             


Ile Ser  Tyr Thr Gly Ala Asp  Ile Cys Gly Phe Phe  Gln Asp Ala 
    1550                 1555                 1560             


Glu Tyr  Glu Met Cys Val Arg  Trp Met Gln Leu Gly  Ala Phe Tyr 
    1565                 1570                 1575             


Pro Phe  Ser Arg Asn His Asn  Thr Ile Gly Thr Arg  Arg Gln Asp 
    1580                 1585                 1590             


Pro Val  Ser Trp Asp Val Ala  Phe Val Asn Ile Ser  Arg Thr Val 
    1595                 1600                 1605             


Leu Gln  Thr Arg Tyr Thr Leu  Leu Pro Tyr Leu Tyr  Thr Leu Met 
    1610                 1615                 1620             


His Lys  Ala His Thr Glu Gly  Val Thr Val Val Arg  Pro Leu Leu 
    1625                 1630                 1635             


His Glu  Phe Val Ser Asp Gln  Val Thr Trp Asp Ile  Asp Ser Gln 
    1640                 1645                 1650             


Phe Leu  Leu Gly Pro Ala Phe  Leu Val Ser Pro Val  Leu Glu Arg 
    1655                 1660                 1665             


Asn Ala  Arg Asn Val Thr Ala  Tyr Phe Pro Arg Ala  Arg Trp Tyr 
    1670                 1675                 1680             


Asp Tyr  Tyr Thr Gly Val Asp  Ile Asn Ala Arg Gly  Glu Trp Lys 
    1685                 1690                 1695             


Thr Leu  Pro Ala Pro Leu Asp  His Ile Asn Leu His  Val Arg Gly 
    1700                 1705                 1710             


Gly Tyr  Ile Leu Pro Trp Gln  Glu Pro Ala Leu Asn  Thr His Leu 
    1715                 1720                 1725             


Ser Arg  Gln Lys Phe Met Gly  Phe Lys Ile Ala Leu  Asp Asp Glu 
    1730                 1735                 1740             


Gly Thr  Ala Gly Gly Trp Leu  Phe Trp Asp Asp Gly  Gln Ser Ile 
    1745                 1750                 1755             


Asp Thr  Tyr Gly Lys Gly Leu  Tyr Tyr Leu Ala Ser  Phe Ser Ala 
    1760                 1765                 1770             


Ser Gln  Asn Thr Met Gln Ser  His Ile Ile Phe Asn  Asn Tyr Ile 
    1775                 1780                 1785             


Thr Gly  Thr Asn Pro Leu Lys  Leu Gly Tyr Ile Glu  Ile Trp Gly 
    1790                 1795                 1800             


Val Gly  Ser Val Pro Val Thr  Ser Val Ser Ile Ser  Val Ser Gly 
    1805                 1810                 1815             


Met Val  Ile Thr Pro Ser Phe  Asn Asn Asp Pro Thr  Thr Gln Val 
    1820                 1825                 1830             


Leu Ser  Ile Asp Val Thr Asp  Arg Asn Ile Ser Leu  His Asn Phe 
    1835                 1840                 1845             


Thr Ser  Leu Thr Trp Ile Ser  Thr Leu 
    1850                 1855         


<210>  3100
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  3100

Met Lys Thr Phe Thr Trp Thr Leu Gly Val Leu Phe Phe Leu Leu Val 
1               5                   10                  15      


Asp Thr Gly His Cys Arg Gly Gly Gln Phe Lys Ile Lys Lys Ile Asn 
            20                  25                  30          


Gln Arg Arg Tyr Pro Arg Ala Thr Asp Gly Lys Glu Glu Ala Lys Lys 
        35                  40                  45              


Cys Ala Tyr Thr Phe Leu Val Pro Glu Gln Arg Ile Thr Gly Pro Ile 
    50                  55                  60                  


Cys Val Asn Thr Lys Gly Gln Asp Ala Ser Thr Ile Lys Asp Met Ile 
65                  70                  75                  80  


Thr Arg Met Asp Leu Glu Asn Leu Lys Asp Val Leu Ser Arg Gln Lys 
                85                  90                  95      


Arg Glu Ile Asp Val Leu Gln Leu Val Val Asp Val Asp Gly Asn Ile 
            100                 105                 110         


Val Asn Glu Val Lys Leu Leu Arg Lys Glu Ser Arg Asn Met Asn Ser 
        115                 120                 125             


Arg Val Thr Gln Leu Tyr Met Gln Leu Leu His Glu Ile Ile Arg Lys 
    130                 135                 140                 


Arg Asp Asn Ser Leu Glu Leu Ser Gln Leu Glu Asn Lys Ile Leu Asn 
145                 150                 155                 160 


Val Thr Thr Glu Met Leu Lys Met Ala Thr Arg Tyr Arg Glu Leu Glu 
                165                 170                 175     


Val Lys Tyr Ala Ser Leu Thr Asp Leu Val Asn Asn Gln Ser Val Met 
            180                 185                 190         


Ile Thr Leu Leu Glu Glu Gln Cys Leu Arg Ile Phe Ser Arg Gln Asp 
        195                 200                 205             


Thr His Val Ser Pro Pro Leu Val Gln Val Val Pro Gln His Ile Pro 
    210                 215                 220                 


Asn Ser Gln Gln Tyr Thr Pro Gly Leu Leu Gly Gly Asn Glu Ile Gln 
225                 230                 235                 240 


Arg Asp Pro Gly Tyr Pro Arg Asp Leu Met Pro Pro Pro Asp Leu Ala 
                245                 250                 255     


Thr Ser Pro Thr Lys Ser Pro Phe Lys Ile Pro Pro Val Thr Phe Ile 
            260                 265                 270         


Asn Glu Gly Pro Phe Lys Asp Cys Gln Gln Ala Lys Glu Ala Gly His 
        275                 280                 285             


Ser Val Ser Gly Ile Tyr Met Ile Lys Pro Glu Asn Ser Asn Gly Pro 
    290                 295                 300                 


Met Gln Leu Trp Cys Glu Asn Ser Leu Asp Pro Gly Gly Trp Thr Val 
305                 310                 315                 320 


Ile Gln Lys Arg Thr Asp Gly Ser Val Asn Phe Phe Arg Asn Trp Glu 
                325                 330                 335     


Asn Tyr Lys Lys Gly Phe Gly Asn Ile Asp Gly Glu Tyr Trp Leu Gly 
            340                 345                 350         


Leu Glu Asn Ile Tyr Met Leu Ser Asn Gln Asp Asn Tyr Lys Leu Leu 
        355                 360                 365             


Ile Glu Leu Glu Asp Trp Ser Asp Lys Lys Val Tyr Ala Glu Tyr Ser 
    370                 375                 380                 


Ser Phe Arg Leu Glu Pro Glu Ser Glu Phe Tyr Arg Leu Arg Leu Gly 
385                 390                 395                 400 


Thr Tyr Gln Gly Asn Ala Gly Asp Ser Met Met Trp His Asn Gly Lys 
                405                 410                 415     


Gln Phe Thr Thr Leu Asp Arg Asp Lys Asp Met Tyr Ala Gly Asn Cys 
            420                 425                 430         


Ala His Phe His Lys Gly Gly Trp Trp Tyr Asn Ala Cys Ala His Ser 
        435                 440                 445             


Asn Leu Asn Gly Val Trp Tyr Arg Gly Gly His Tyr Arg Ser Lys His 
    450                 455                 460                 


Gln Asp Gly Ile Phe Trp Ala Glu Tyr Arg Gly Gly Ser Tyr Ser Leu 
465                 470                 475                 480 


Arg Ala Val Gln Met Met Ile Lys Pro Ile Asp 
                485                 490     


<210>  3101
<211>  523
<212>  PRT
<213>  Homo sapiens

<400>  3101

Met Thr Gln Asn Lys Leu Lys Leu Cys Ser Lys Ala Asn Val Tyr Thr 
1               5                   10                  15      


Glu Val Pro Asp Gly Gly Trp Gly Trp Ala Val Ala Val Ser Phe Phe 
            20                  25                  30          


Phe Val Glu Val Phe Thr Tyr Gly Ile Ile Lys Thr Phe Gly Val Phe 
        35                  40                  45              


Phe Asn Asp Leu Met Asp Ser Phe Asn Glu Ser Asn Ser Arg Ile Ser 
    50                  55                  60                  


Trp Ile Ile Ser Ile Cys Val Phe Val Leu Thr Phe Ser Ala Pro Leu 
65                  70                  75                  80  


Ala Thr Val Leu Ser Asn Arg Phe Gly His Arg Leu Val Val Met Leu 
                85                  90                  95      


Gly Gly Leu Leu Val Ser Thr Gly Met Val Ala Ala Ser Phe Ser Gln 
            100                 105                 110         


Glu Val Ser His Met Tyr Val Ala Ile Gly Ile Ile Ser Gly Leu Gly 
        115                 120                 125             


Tyr Cys Phe Ser Phe Leu Pro Thr Val Thr Ile Leu Ser Gln Tyr Phe 
    130                 135                 140                 


Gly Lys Arg Arg Ser Ile Val Thr Ala Val Ala Ser Thr Gly Glu Cys 
145                 150                 155                 160 


Phe Ala Val Phe Ala Phe Ala Pro Ala Ile Met Ala Leu Lys Glu Arg 
                165                 170                 175     


Ile Gly Trp Arg Tyr Ser Leu Leu Phe Val Gly Leu Leu Gln Leu Asn 
            180                 185                 190         


Ile Val Ile Phe Gly Ala Leu Leu Arg Pro Ile Phe Ile Arg Gly Pro 
        195                 200                 205             


Ala Ser Pro Lys Ile Val Ile Gln Glu Asn Arg Lys Glu Ala Gln Tyr 
    210                 215                 220                 


Met Leu Glu Asn Glu Lys Thr Arg Thr Ser Ile Asp Ser Ile Asp Ser 
225                 230                 235                 240 


Gly Val Glu Leu Thr Thr Ser Pro Lys Asn Val Pro Thr His Thr Asn 
                245                 250                 255     


Leu Glu Leu Glu Pro Lys Ala Asp Met Gln Gln Val Leu Val Lys Thr 
            260                 265                 270         


Ser Pro Arg Pro Ser Glu Lys Lys Ala Pro Leu Leu Asp Phe Ser Ile 
        275                 280                 285             


Leu Lys Glu Lys Ser Phe Ile Cys Tyr Ala Leu Phe Gly Leu Phe Ala 
    290                 295                 300                 


Thr Leu Gly Phe Phe Ala Pro Ser Leu Tyr Ile Ile Pro Leu Gly Ile 
305                 310                 315                 320 


Ser Leu Gly Ile Asp Gln Asp Arg Ala Ala Phe Leu Leu Ser Thr Met 
                325                 330                 335     


Ala Ile Ala Glu Val Phe Gly Arg Ile Gly Ala Gly Phe Val Leu Asn 
            340                 345                 350         


Arg Glu Pro Ile Arg Lys Ile Tyr Ile Glu Leu Ile Cys Val Ile Leu 
        355                 360                 365             


Leu Thr Val Ser Leu Phe Ala Phe Thr Phe Ala Thr Glu Phe Trp Gly 
    370                 375                 380                 


Leu Met Ser Cys Ser Ile Phe Phe Gly Phe Met Val Gly Thr Ile Gly 
385                 390                 395                 400 


Gly Thr His Ile Pro Leu Leu Ala Glu Asp Asp Val Val Gly Ile Glu 
                405                 410                 415     


Lys Met Ser Ser Ala Ala Gly Val Tyr Ile Phe Ile Gln Ser Ile Ala 
            420                 425                 430         


Gly Leu Ala Gly Pro Pro Leu Ala Gly Leu Leu Val Asp Gln Ser Lys 
        435                 440                 445             


Ile Tyr Ser Arg Ala Phe Tyr Ser Cys Ala Ala Gly Met Ala Leu Ala 
    450                 455                 460                 


Ala Val Cys Leu Ala Leu Val Arg Pro Cys Lys Met Gly Leu Cys Gln 
465                 470                 475                 480 


His His His Ser Gly Glu Thr Lys Val Val Ser His Arg Gly Lys Thr 
                485                 490                 495     


Leu Gln Asp Ile Pro Glu Asp Phe Leu Glu Met Asp Leu Ala Lys Asn 
            500                 505                 510         


Glu His Arg Val His Val Gln Met Glu Pro Val 
        515                 520             


<210>  3102
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  3102

Met Pro Gln Ala Leu Glu Arg Ala Asp Gly Ser Trp Ala Trp Val Val 
1               5                   10                  15      


Leu Leu Ala Thr Met Val Thr Gln Gly Leu Thr Leu Gly Phe Pro Thr 
            20                  25                  30          


Cys Ile Gly Ile Phe Phe Thr Glu Leu Gln Trp Glu Phe Gln Ala Ser 
        35                  40                  45              


Asn Ser Glu Thr Ser Trp Phe Pro Ser Ile Leu Thr Ala Val Leu His 
    50                  55                  60                  


Met Ala Gly Pro Leu Cys Ser Ile Leu Val Gly Arg Phe Gly Cys Arg 
65                  70                  75                  80  


Val Thr Val Met Leu Gly Gly Val Leu Ala Ser Leu Gly Met Val Ala 
                85                  90                  95      


Ser Ser Phe Ser His Asn Leu Ser Gln Leu Tyr Phe Thr Ala Gly Phe 
            100                 105                 110         


Ile Thr Gly Leu Gly Met Cys Phe Ser Phe Gln Ser Ser Ile Thr Val 
        115                 120                 125             


Leu Gly Phe Tyr Phe Val Arg Arg Arg Val Leu Ala Asn Ala Leu Ala 
    130                 135                 140                 


Ser Met Gly Val Ser Leu Gly Ile Thr Leu Trp Pro Leu Leu Ser Arg 
145                 150                 155                 160 


Tyr Leu Leu Glu Asn Leu Gly Trp Arg Gly Thr Phe Leu Val Phe Gly 
                165                 170                 175     


Gly Ile Phe Leu His Cys Cys Ile Cys Gly Ala Ile Ile Arg Pro Val 
            180                 185                 190         


Ala Thr Ser Val Ala Pro Glu Thr Lys Glu Cys Pro Pro Pro Pro Pro 
        195                 200                 205             


Glu Thr Pro Ala Leu Gly Cys Leu Ala Ala Cys Gly Arg Thr Ile Gln 
    210                 215                 220                 


Arg His Leu Ala Phe Asp Ile Leu Arg His Asn Thr Gly Tyr Cys Val 
225                 230                 235                 240 


Tyr Ile Leu Gly Val Met Trp Ser Val Leu Gly Phe Pro Leu Pro Gln 
                245                 250                 255     


Val Phe Leu Val Pro Tyr Ala Met Trp His Ser Val Asp Glu Gln Gln 
            260                 265                 270         


Ala Ala Leu Leu Ile Ser Ile Ile Gly Phe Ser Asn Ile Phe Leu Arg 
        275                 280                 285             


Pro Leu Ala Gly Leu Met Ala Gly Arg Pro Ala Phe Ala Ser His Arg 
    290                 295                 300                 


Lys Tyr Leu Phe Ser Leu Ala Leu Leu Leu Asn Gly Leu Thr Asn Leu 
305                 310                 315                 320 


Val Cys Ala Ala Ser Gly Asp Phe Trp Val Leu Val Gly Tyr Cys Leu 
                325                 330                 335     


Ala Tyr Ser Val Ser Met Ser Gly Ile Gly Ala Leu Ile Phe Gln Val 
            340                 345                 350         


Leu Met Asp Ile Val Pro Met Asp Gln Phe Pro Arg Ala Leu Gly Leu 
        355                 360                 365             


Phe Thr Val Leu Asp Gly Leu Ala Phe Leu Ile Ser Pro Pro Leu Ala 
    370                 375                 380                 


Gly Leu Leu Leu Asp Ala Thr Asn Asn Phe Ser Tyr Val Phe Tyr Met 
385                 390                 395                 400 


Ser Ser Phe Phe Leu Ile Ser Ala Ala Leu Phe Met Gly Gly Ser Phe 
                405                 410                 415     


Tyr Ala Leu Gln Lys Lys Glu Gln Gly Lys Gln Ala Val Ala Ala Asp 
            420                 425                 430         


Ala Leu Glu Arg Asp Leu Phe Leu Glu Ala Lys Asp Gly Pro Gly Lys 
        435                 440                 445             


Gln Arg Ser Pro Glu Ile Met Cys Gln Ser Ser Arg Gln Pro Arg Pro 
    450                 455                 460                 


Ala Gly Val Asn Lys His Leu Trp Gly Cys Pro Ala Ser Ser Arg Thr 
465                 470                 475                 480 


Ser His Glu Trp Leu Leu Trp Pro Lys Ala Val Leu Gln Ala Lys Gln 
                485                 490                 495     


Thr Ala Leu Gly Trp Asn Ser Pro Thr 
            500                 505 


<210>  3103
<211>  487
<212>  PRT
<213>  Homo sapiens

<400>  3103

Met Leu Lys Arg Glu Gly Lys Val Gln Pro Tyr Thr Lys Thr Leu Asp 
1               5                   10                  15      


Gly Gly Trp Gly Trp Met Ile Val Ile His Phe Phe Leu Val Asn Val 
            20                  25                  30          


Phe Val Met Gly Met Thr Lys Thr Phe Ala Ile Phe Phe Val Val Phe 
        35                  40                  45              


Gln Glu Glu Phe Glu Gly Thr Ser Glu Gln Ile Gly Trp Ile Gly Ser 
    50                  55                  60                  


Ile Met Ser Ser Leu Arg Phe Cys Ala Gly Pro Leu Val Ala Ile Ile 
65                  70                  75                  80  


Cys Asp Ile Leu Gly Glu Lys Thr Thr Ser Ile Leu Gly Ala Phe Val 
                85                  90                  95      


Val Thr Gly Gly Tyr Leu Ile Ser Ser Trp Ala Thr Ser Ile Pro Phe 
            100                 105                 110         


Leu Cys Val Thr Met Gly Leu Leu Pro Gly Leu Gly Ser Ala Phe Leu 
        115                 120                 125             


Tyr Gln Val Ala Ala Val Val Thr Thr Lys Tyr Phe Lys Lys Arg Leu 
    130                 135                 140                 


Ala Leu Ser Thr Ala Ile Ala Arg Ser Gly Met Gly Leu Thr Phe Leu 
145                 150                 155                 160 


Leu Ala Pro Phe Thr Lys Phe Leu Ile Asp Leu Tyr Asp Trp Thr Gly 
                165                 170                 175     


Ala Leu Ile Leu Phe Gly Ala Ile Ala Leu Asn Leu Val Pro Ser Ser 
            180                 185                 190         


Met Leu Leu Arg Pro Ile His Ile Lys Ser Glu Asn Asn Ser Gly Ile 
        195                 200                 205             


Lys Asp Lys Gly Ser Ser Leu Ser Ala His Gly Pro Glu Ala His Ala 
    210                 215                 220                 


Thr Glu Thr His Cys His Glu Thr Glu Glu Ser Thr Ile Lys Asp Ser 
225                 230                 235                 240 


Thr Thr Gln Lys Ala Gly Leu Pro Ser Lys Asn Leu Thr Val Ser Gln 
                245                 250                 255     


Asn Gln Ser Glu Glu Phe Tyr Asn Gly Pro Asn Arg Asn Arg Leu Leu 
            260                 265                 270         


Leu Lys Ser Asp Glu Glu Ser Asp Lys Val Ile Ser Trp Ser Cys Lys 
        275                 280                 285             


Gln Leu Phe Asp Ile Ser Leu Phe Arg Asn Pro Phe Phe Tyr Ile Phe 
    290                 295                 300                 


Thr Trp Ser Phe Leu Leu Ser Gln Leu Ala Tyr Phe Ile Pro Thr Phe 
305                 310                 315                 320 


His Leu Val Ala Arg Ala Lys Thr Leu Gly Ile Asp Ile Met Asp Ala 
                325                 330                 335     


Ser Tyr Leu Val Ser Val Ala Gly Ile Leu Glu Thr Val Ser Gln Ile 
            340                 345                 350         


Ile Ser Gly Trp Val Ala Asp Gln Asn Trp Ile Lys Lys Tyr His Tyr 
        355                 360                 365             


His Lys Ser Tyr Leu Ile Leu Cys Gly Ile Thr Asn Leu Leu Ala Pro 
    370                 375                 380                 


Leu Ala Thr Thr Phe Pro Leu Leu Met Thr Tyr Thr Ile Cys Phe Ala 
385                 390                 395                 400 


Ile Phe Ala Gly Gly Tyr Leu Ala Leu Ile Leu Pro Val Leu Val Asp 
                405                 410                 415     


Leu Cys Arg Asn Ser Thr Val Asn Arg Phe Leu Gly Leu Ala Ser Phe 
            420                 425                 430         


Phe Ala Gly Met Ala Val Leu Ser Gly Pro Pro Ile Ala Gly Trp Leu 
        435                 440                 445             


Tyr Asp Tyr Thr Gln Thr Tyr Asn Gly Ser Phe Tyr Phe Ser Gly Ile 
    450                 455                 460                 


Cys Tyr Leu Leu Ser Ser Val Ser Phe Phe Phe Val Pro Leu Ala Glu 
465                 470                 475                 480 


Arg Trp Lys Asn Ser Leu Thr 
                485         


<210>  3104
<211>  695
<212>  PRT
<213>  Homo sapiens

<400>  3104

Met Ala Glu Ala Pro Pro Arg Arg Leu Gly Leu Gly Pro Pro Pro Gly 
1               5                   10                  15      


Asp Ala Pro Arg Ala Glu Leu Val Ala Leu Thr Ala Val Gln Ser Glu 
            20                  25                  30          


Gln Gly Glu Ala Gly Gly Gly Gly Ser Pro Arg Arg Leu Gly Leu Leu 
        35                  40                  45              


Gly Ser Pro Leu Pro Pro Gly Ala Pro Leu Pro Gly Pro Gly Ser Gly 
    50                  55                  60                  


Ser Gly Ser Ala Cys Gly Gln Arg Ser Ser Ala Ala His Lys Arg Tyr 
65                  70                  75                  80  


Arg Arg Leu Gln Asn Trp Val Tyr Asn Val Leu Glu Arg Pro Arg Gly 
                85                  90                  95      


Trp Ala Phe Val Tyr His Val Phe Ile Phe Leu Leu Val Phe Ser Cys 
            100                 105                 110         


Leu Val Leu Ser Val Leu Ser Thr Ile Gln Glu His Gln Glu Leu Ala 
        115                 120                 125             


Asn Glu Cys Leu Leu Ile Leu Glu Phe Val Met Ile Val Val Phe Gly 
    130                 135                 140                 


Leu Glu Tyr Ile Val Arg Val Trp Ser Ala Gly Cys Cys Cys Arg Tyr 
145                 150                 155                 160 


Arg Gly Trp Gln Gly Arg Phe Arg Phe Ala Arg Lys Pro Phe Cys Val 
                165                 170                 175     


Ile Asp Phe Ile Val Phe Val Ala Ser Val Ala Val Ile Ala Ala Gly 
            180                 185                 190         


Thr Gln Gly Asn Ile Phe Ala Thr Ser Ala Leu Arg Ser Met Arg Phe 
        195                 200                 205             


Leu Gln Ile Leu Arg Met Val Arg Met Asp Arg Arg Gly Gly Thr Trp 
    210                 215                 220                 


Lys Leu Leu Gly Ser Val Val Tyr Ala His Ser Lys Glu Leu Ile Thr 
225                 230                 235                 240 


Ala Trp Tyr Ile Gly Phe Leu Val Leu Ile Phe Ala Ser Phe Leu Val 
                245                 250                 255     


Tyr Leu Ala Glu Lys Asp Ala Asn Ser Asp Phe Ser Ser Tyr Ala Asp 
            260                 265                 270         


Ser Leu Trp Trp Gly Thr Ile Thr Leu Thr Thr Ile Gly Tyr Gly Asp 
        275                 280                 285             


Lys Thr Pro His Thr Trp Leu Gly Arg Val Leu Ala Ala Gly Phe Ala 
    290                 295                 300                 


Leu Leu Gly Ile Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu Gly Ser 
305                 310                 315                 320 


Gly Phe Ala Leu Lys Val Gln Glu Gln His Arg Gln Lys His Phe Glu 
                325                 330                 335     


Lys Arg Arg Met Pro Ala Ala Asn Leu Ile Gln Ala Ala Trp Arg Leu 
            340                 345                 350         


Tyr Ser Thr Asp Met Ser Arg Ala Tyr Leu Thr Ala Thr Trp Tyr Tyr 
        355                 360                 365             


Tyr Asp Ser Ile Leu Pro Ser Phe Arg Glu Leu Ala Leu Leu Phe Glu 
    370                 375                 380                 


His Val Gln Arg Ala Arg Asn Gly Gly Leu Arg Pro Leu Glu Val Arg 
385                 390                 395                 400 


Arg Ala Pro Val Pro Asp Gly Ala Pro Ser Arg Tyr Pro Pro Val Ala 
                405                 410                 415     


Thr Cys His Arg Pro Gly Ser Thr Ser Phe Cys Pro Gly Glu Ser Ser 
            420                 425                 430         


Arg Met Gly Ile Lys Asp Arg Ile Arg Met Gly Ser Ser Gln Arg Arg 
        435                 440                 445             


Thr Gly Pro Ser Lys Gln His Leu Ala Pro Pro Thr Met Pro Thr Ser 
    450                 455                 460                 


Pro Ser Ser Glu Gln Val Gly Glu Ala Thr Ser Pro Thr Lys Val Gln 
465                 470                 475                 480 


Lys Ser Trp Ser Phe Asn Asp Arg Thr Arg Phe Arg Ala Ser Leu Arg 
                485                 490                 495     


Leu Lys Pro Arg Thr Ser Ala Glu Asp Ala Pro Ser Glu Glu Val Ala 
            500                 505                 510         


Glu Glu Lys Ser Tyr Gln Cys Glu Leu Thr Val Asp Asp Ile Met Pro 
        515                 520                 525             


Ala Val Lys Thr Val Ile Arg Ser Ile Arg Ile Leu Lys Phe Leu Val 
    530                 535                 540                 


Ala Lys Arg Lys Phe Lys Glu Thr Leu Arg Pro Tyr Asp Val Lys Asp 
545                 550                 555                 560 


Val Ile Glu Gln Tyr Ser Ala Gly His Leu Asp Met Leu Gly Arg Ile 
                565                 570                 575     


Lys Ser Leu Gln Thr Arg Val Asp Gln Ile Val Gly Arg Gly Pro Gly 
            580                 585                 590         


Asp Arg Lys Ala Arg Glu Lys Gly Asp Lys Gly Pro Ser Asp Ala Glu 
        595                 600                 605             


Val Val Asp Glu Ile Ser Met Met Gly Arg Val Val Lys Val Glu Lys 
    610                 615                 620                 


Gln Val Gln Ser Ile Glu His Lys Leu Asp Leu Leu Leu Gly Phe Tyr 
625                 630                 635                 640 


Ser Arg Cys Leu Arg Ser Gly Thr Ser Ala Ser Leu Gly Ala Val Gln 
                645                 650                 655     


Val Pro Leu Phe Asp Pro Asp Ile Thr Ser Asp Tyr His Ser Pro Val 
            660                 665                 670         


Asp His Glu Asp Ile Ser Val Ser Ala Gln Thr Leu Ser Ile Ser Arg 
        675                 680                 685             


Ser Val Ser Thr Asn Met Asp 
    690                 695 


<210>  3105
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  3105

Met Tyr Ser Arg Leu Phe Tyr Leu Lys Ser Ser Tyr Ile Ile Tyr Phe 
1               5                   10                  15      


Glu Pro Leu Phe Ser Asn Ala Ile Ile Asn Ile Leu Ser Phe Ile Asn 
            20                  25                  30          


Ser Leu Ala Ser Pro Leu Thr Ile Phe Cys Phe Ala Leu Ser Ala Gln 
        35                  40                  45              


Ala Leu Ser Thr Ile Phe Tyr Phe Arg Ile Phe Ile Phe Ile Phe His 
    50                  55                  60                  


Ser Trp Ile Leu Leu Phe His Phe Tyr Phe Thr Cys Ser Phe Lys Thr 
65                  70                  75                  80  


Tyr Glu His Gln His Ser Lys Met Val Pro Ala Tyr Arg Met Gln Ser 
                85                  90                  95      


Pro Arg Ala Leu Pro Arg Thr Tyr Leu Tyr Val Trp Pro Tyr Lys 
            100                 105                 110     


<210>  3106
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  3106

Met Glu Ser Gly Ala Tyr Gly Ala Ala Lys Ala Gly Gly Ser Phe Asp 
1               5                   10                  15      


Leu Arg Arg Phe Leu Thr Gln Pro Gln Val Val Ala Arg Ala Val Cys 
            20                  25                  30          


Leu Val Phe Ala Leu Ile Val Phe Ser Cys Ile Tyr Gly Glu Gly Tyr 
        35                  40                  45              


Ser Asn Ala His Glu Ser Lys Gln Met Tyr Cys Val Phe Asn Arg Asn 
    50                  55                  60                  


Glu Asp Ala Cys Arg Tyr Gly Ser Ala Ile Gly Val Leu Ala Phe Leu 
65                  70                  75                  80  


Ala Ser Ala Phe Phe Leu Val Val Asp Ala Tyr Phe Pro Gln Ile Ser 
                85                  90                  95      


Asn Ala Thr Asp Arg Lys Tyr Leu Val Ile Gly Asp Leu Leu Phe Ser 
            100                 105                 110         


Ala Leu Trp Thr Phe Leu Trp Phe Val Gly Phe Cys Phe Leu Thr Asn 
        115                 120                 125             


Gln Trp Ala Val Thr Asn Pro Lys Asp Val Leu Val Gly Ala Asp Ser 
    130                 135                 140                 


Val Arg Ala Ala Ile Thr Phe Ser Phe Phe Ser Ile Phe Ser Trp Gly 
145                 150                 155                 160 


Val Leu Ala Ser Leu Ala Tyr Gln Arg Tyr Lys Ala Gly Val Asp Asp 
                165                 170                 175     


Phe Ile Gln Asn Tyr Val Asp Pro Thr Pro Asp Pro Asn Thr Ala Tyr 
            180                 185                 190         


Ala Ser Tyr Pro Gly Ala Ser Val Asp Asn Tyr Gln Gln Pro Pro Phe 
        195                 200                 205             


Thr Gln Asn Ala Glu Thr Thr Glu Gly Tyr Gln Pro Pro Pro Val Tyr 
    210                 215                 220                 


<210>  3107
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  3107

Met Glu Gly Gly Ala Tyr Gly Ala Gly Lys Ala Gly Gly Ala Phe Asp 
1               5                   10                  15      


Pro Tyr Thr Leu Val Arg Gln Pro His Thr Ile Leu Arg Val Val Ser 
            20                  25                  30          


Trp Leu Phe Ser Ile Val Val Phe Gly Ser Ile Val Asn Glu Gly Tyr 
        35                  40                  45              


Leu Asn Ser Ala Ser Glu Gly Glu Glu Phe Cys Ile Tyr Asn Arg Asn 
    50                  55                  60                  


Pro Asn Ala Cys Ser Tyr Gly Val Ala Val Gly Val Leu Ala Phe Leu 
65                  70                  75                  80  


Thr Cys Leu Leu Tyr Leu Ala Leu Asp Val Tyr Phe Pro Gln Ile Ser 
                85                  90                  95      


Ser Val Lys Asp Arg Lys Lys Ala Val Leu Ser Asp Ile Gly Val Ser 
            100                 105                 110         


Ala Phe Trp Ala Phe Leu Trp Phe Val Gly Phe Cys Tyr Leu Ala Asn 
        115                 120                 125             


Gln Trp Gln Val Ser Lys Pro Lys Asp Asn Pro Leu Asn Glu Gly Thr 
    130                 135                 140                 


Asp Ala Ala Arg Ala Ala Ile Ala Phe Ser Phe Phe Ser Ile Phe Thr 
145                 150                 155                 160 


Trp Ala Gly Gln Ala Val Leu Ala Phe Gln Arg Tyr Gln Ile Gly Ala 
                165                 170                 175     


Asp Ser Ala Leu Phe Ser Gln Asp Tyr Met Asp Pro Ser Gln Asp Ser 
            180                 185                 190         


Ser Met Pro Tyr Ala Pro Tyr Val Glu Pro Thr Gly Pro Asp Pro Ala 
        195                 200                 205             


Gly Met Gly Gly Thr Tyr Gln Gln Pro Ala Asn Thr Phe Asp Thr Glu 
    210                 215                 220                 


Pro Gln Gly Tyr Gln Ser Gln Gly Tyr 
225                 230             


<210>  3108
<211>  785
<212>  PRT
<213>  Homo sapiens

<400>  3108

Met Pro Lys Gly Arg Gln Lys Val Pro His Leu Asp Ala Pro Leu Gly 
1               5                   10                  15      


Leu Pro Thr Cys Leu Trp Leu Glu Leu Ala Gly Leu Phe Leu Leu Val 
            20                  25                  30          


Pro Trp Val Met Gly Leu Ala Gly Thr Gly Gly Pro Asp Gly Gln Gly 
        35                  40                  45              


Thr Gly Gly Pro Ser Trp Ala Val His Leu Glu Ser Leu Glu Gly Asp 
    50                  55                  60                  


Gly Glu Glu Glu Thr Leu Glu Gln Gln Ala Asp Ala Leu Ala Gln Ala 
65                  70                  75                  80  


Ala Gly Leu Val Asn Ala Gly Arg Ile Gly Glu Leu Gln Gly His Tyr 
                85                  90                  95      


Leu Phe Val Gln Pro Ala Gly His Arg Pro Ala Leu Glu Val Glu Ala 
            100                 105                 110         


Ile Arg Gln Gln Val Glu Ala Val Leu Ala Gly His Glu Ala Val Arg 
        115                 120                 125             


Trp His Ser Glu Gln Arg Leu Leu Arg Arg Ala Lys Arg Ser Val His 
    130                 135                 140                 


Phe Asn Asp Pro Lys Tyr Pro Gln Gln Trp His Leu Asn Asn Arg Arg 
145                 150                 155                 160 


Ser Pro Gly Arg Asp Ile Asn Val Thr Gly Val Trp Glu Arg Asn Val 
                165                 170                 175     


Thr Gly Arg Gly Val Thr Val Val Val Val Asp Asp Gly Val Glu His 
            180                 185                 190         


Thr Ile Gln Asp Ile Ala Pro Asn Tyr Ser Pro Glu Gly Ser Tyr Asp 
        195                 200                 205             


Leu Asn Ser Asn Asp Pro Asp Pro Met Pro His Pro Asp Val Glu Asn 
    210                 215                 220                 


Gly Asn His His Gly Thr Arg Cys Ala Gly Glu Ile Ala Ala Val Pro 
225                 230                 235                 240 


Asn Asn Ser Phe Cys Ala Val Gly Val Ala Tyr Gly Ser Arg Ile Ala 
                245                 250                 255     


Gly Ile Arg Val Leu Asp Gly Pro Leu Thr Asp Ser Met Glu Ala Val 
            260                 265                 270         


Ala Phe Asn Lys His Tyr Gln Ile Asn Asp Ile Tyr Ser Cys Ser Trp 
        275                 280                 285             


Gly Pro Asp Asp Asp Gly Lys Thr Val Asp Gly Pro His Gln Leu Gly 
    290                 295                 300                 


Lys Ala Ala Leu Gln His Gly Val Ile Ala Gly Arg Gln Gly Phe Gly 
305                 310                 315                 320 


Ser Ile Phe Val Val Ala Ser Gly Asn Gly Gly Gln His Asn Asp Asn 
                325                 330                 335     


Cys Asn Tyr Asp Gly Tyr Ala Asn Ser Ile Tyr Thr Val Thr Ile Gly 
            340                 345                 350         


Ala Val Asp Glu Glu Gly Arg Met Pro Phe Tyr Ala Glu Glu Cys Ala 
        355                 360                 365             


Ser Met Leu Ala Val Thr Phe Ser Gly Gly Asp Lys Met Leu Arg Ser 
    370                 375                 380                 


Ile Val Thr Thr Asp Trp Asp Leu Gln Lys Gly Thr Gly Cys Thr Glu 
385                 390                 395                 400 


Gly His Thr Gly Thr Ser Ala Ala Ala Pro Leu Ala Ala Gly Met Ile 
                405                 410                 415     


Ala Leu Met Leu Gln Val Arg Pro Cys Leu Thr Trp Arg Asp Val Gln 
            420                 425                 430         


His Ile Ile Val Phe Thr Ala Thr Arg Tyr Glu Asp Arg Arg Ala Glu 
        435                 440                 445             


Trp Val Thr Asn Glu Ala Gly Phe Ser His Ser His Gln His Gly Phe 
    450                 455                 460                 


Gly Leu Leu Asn Ala Trp Arg Leu Val Asn Ala Ala Lys Ile Trp Thr 
465                 470                 475                 480 


Ser Val Pro Tyr Leu Ala Ser Tyr Val Ser Pro Val Leu Lys Glu Asn 
                485                 490                 495     


Lys Ala Ile Pro Gln Ser Pro Arg Ser Leu Glu Val Leu Trp Asn Val 
            500                 505                 510         


Ser Arg Met Asp Leu Glu Met Ser Gly Leu Lys Thr Leu Glu His Val 
        515                 520                 525             


Ala Val Thr Val Ser Ile Thr His Pro Arg Arg Gly Ser Leu Glu Leu 
    530                 535                 540                 


Lys Leu Phe Cys Pro Ser Gly Met Met Ser Leu Ile Gly Ala Pro Arg 
545                 550                 555                 560 


Ser Met Asp Ser Asp Pro Asn Gly Phe Asn Asp Trp Thr Phe Ser Thr 
                565                 570                 575     


Val Arg Cys Trp Gly Glu Arg Ala Arg Gly Thr Tyr Arg Leu Val Ile 
            580                 585                 590         


Arg Asp Val Gly Asp Glu Ser Phe Gln Val Gly Ile Leu Arg Gln Trp 
        595                 600                 605             


Gln Leu Thr Leu Tyr Gly Ser Val Trp Ser Ala Val Asp Ile Arg Asp 
    610                 615                 620                 


Arg Gln Arg Leu Leu Glu Ser Ala Met Ser Gly Lys Tyr Leu His Asp 
625                 630                 635                 640 


Asp Phe Ala Leu Pro Cys Pro Pro Gly Leu Lys Ile Pro Glu Glu Asp 
                645                 650                 655     


Gly Tyr Thr Ile Thr Pro Asn Thr Leu Lys Thr Leu Val Leu Val Gly 
            660                 665                 670         


Cys Phe Thr Val Phe Trp Thr Val Tyr Tyr Met Leu Glu Val Tyr Leu 
        675                 680                 685             


Ser Gln Arg Asn Val Ala Ser Asn Gln Val Cys Arg Ser Gly Pro Cys 
    690                 695                 700                 


His Trp Pro His Arg Ser Arg Lys Ala Lys Glu Glu Gly Thr Glu Leu 
705                 710                 715                 720 


Glu Ser Val Pro Leu Cys Ser Ser Lys Asp Pro Asp Glu Val Glu Thr 
                725                 730                 735     


Glu Ser Arg Gly Pro Pro Thr Thr Ser Asp Leu Leu Ala Pro Asp Leu 
            740                 745                 750         


Leu Glu Gln Gly Asp Trp Ser Leu Ser Gln Asn Lys Ser Ala Leu Asp 
        755                 760                 765             


Cys Pro His Gln His Leu Asp Val Pro His Gly Lys Glu Glu Gln Ile 
    770                 775                 780                 


Cys 
785 


<210>  3109
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  3109

Met Tyr Tyr Lys Phe Ser Gly Phe Thr Gln Lys Leu Ala Gly Ala Trp 
1               5                   10                  15      


Ala Ser Glu Ala Tyr Ser Pro Gln Gly Leu Lys Pro Val Val Ser Thr 
            20                  25                  30          


Glu Ala Pro Pro Ile Ile Phe Ala Thr Pro Thr Lys Leu Thr Ser Asp 
        35                  40                  45              


Ser Thr Val Tyr Asp Tyr Ala Gly Lys Asn Lys Val Pro Glu Leu Gln 
    50                  55                  60                  


Lys Phe Phe Gln Lys Ala Asp Gly Val Pro Val Tyr Leu Lys Arg Gly 
65                  70                  75                  80  


Leu Pro Asp Gln Met Leu Tyr Arg Thr Thr Met Ala Leu Thr Val Gly 
                85                  90                  95      


Gly Thr Ile Tyr Cys Leu Ile Ala Leu Tyr Met Ala Ser Gln Pro Lys 
            100                 105                 110         


Asn Lys 
        


<210>  3110
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  3110

Met Pro Pro Met Pro Ser Ala Pro Pro Val His Pro Pro Pro Asp Gly 
1               5                   10                  15      


Gly Trp Gly Trp Ile Val Val Gly Ala Ala Phe Ile Ser Ile Gly Phe 
            20                  25                  30          


Ser Tyr Ala Phe Pro Lys Ala Val Thr Val Phe Phe Lys Glu Ile Gln 
        35                  40                  45              


Gln Ile Phe His Thr Thr Tyr Ser Glu Ile Ala Trp Ile Ser Ser Ile 
    50                  55                  60                  


Met Leu Ala Val Met Tyr Ala Gly Gly Pro Val Ser Ser Val Leu Val 
65                  70                  75                  80  


Asn Lys Tyr Gly Ser Arg Pro Val Val Ile Ala Gly Gly Leu Leu Cys 
                85                  90                  95      


Cys Leu Gly Met Val Leu Ala Ser Phe Ser Ser Ser Val Val Gln Leu 
            100                 105                 110         


Tyr Leu Thr Met Gly Phe Ile Thr Gly Leu Gly Leu Ala Phe Asn Leu 
        115                 120                 125             


Gln Pro Ala Leu Thr Ile Ile Gly Lys Tyr Phe Tyr Arg Lys Arg Pro 
    130                 135                 140                 


Met Ala Asn Gly Leu Ala Met Ala Gly Ser Pro Val Phe Leu Ser Ser 
145                 150                 155                 160 


Leu Ala Pro Phe Asn Gln Tyr Leu Phe Asn Thr Phe Gly Trp Lys Gly 
                165                 170                 175     


Ser Phe Leu Ile Leu Gly Ser Leu Leu Leu Asn Ala Cys Val Ala Gly 
            180                 185                 190         


Ser Leu Met Arg Pro Leu Gly Pro Asn Gln Thr Thr Ser Lys Ser Lys 
        195                 200                 205             


Asn Lys Thr Gly Lys Thr Glu Asp Asp Ser Ser Pro Lys Lys Ile Lys 
    210                 215                 220                 


Thr Lys Lys Ser Thr Trp Glu Lys Val Asn Lys Tyr Leu Asp Phe Ser 
225                 230                 235                 240 


Leu Phe Lys His Arg Gly Phe Leu Ile Tyr Leu Ser Gly Asn Val Ile 
                245                 250                 255     


Met Phe Leu Gly Phe Phe Ala Pro Ile Ile Phe Leu Ala Pro Tyr Ala 
            260                 265                 270         


Lys Asp Gln Gly Ile Asp Glu Tyr Ser Ala Ala Phe Leu Leu Ser Val 
        275                 280                 285             


Met Ala Phe Val Asp Met Phe Ala Arg Pro Ser Val Gly Leu Ile Ala 
    290                 295                 300                 


Asn Ser Lys Tyr Ile Arg Pro Arg Ile Gln Tyr Phe Phe Ser Phe Ala 
305                 310                 315                 320 


Ile Met Phe Asn Gly Val Cys His Leu Leu Cys Pro Leu Ala Gln Asp 
                325                 330                 335     


Tyr Thr Ser Leu Val Leu Tyr Ala Val Phe Phe Gly Leu Gly Phe Gly 
            340                 345                 350         


Ser Val Ser Ser Val Leu Phe Glu Thr Leu Met Asp Leu Val Gly Ala 
        355                 360                 365             


Pro Arg Phe Ser Ser Ala Val Gly Leu Val Thr Ile Val Glu Cys Gly 
    370                 375                 380                 


Pro Val Leu Leu Gly Pro Pro Leu Ala Gly Lys Leu Val Asp Leu Thr 
385                 390                 395                 400 


Gly Glu Tyr Lys Tyr Met Tyr Met Ser Cys Gly Ala Ile Val Val Ala 
                405                 410                 415     


Ala Ser Val Trp Leu Leu Ile Gly Asn Ala Ile Asn Tyr Arg Leu Leu 
            420                 425                 430         


Ala Lys Glu Arg Lys Glu Glu Asn Ala Arg Gln Lys Thr Arg Glu Ser 
        435                 440                 445             


Glu Pro Leu Ser Lys Ser Lys His Ser Glu Asp Val Asn Val Lys Val 
    450                 455                 460                 


Ser Asn Ala Gln Ser Val Thr Ser Glu Arg Glu Thr Asn Ile 
465                 470                 475             


<210>  3111
<211>  549
<212>  PRT
<213>  Homo sapiens

<400>  3111

Met Ser Pro Thr Ile Ser His Lys Asp Ser Ser Arg Gln Arg Arg Pro 
1               5                   10                  15      


Gly Asn Phe Ser His Ser Leu Asp Met Lys Ser Gly Pro Leu Pro Pro 
            20                  25                  30          


Gly Gly Trp Asp Asp Ser His Leu Asp Ser Ala Gly Arg Glu Gly Asp 
        35                  40                  45              


Arg Glu Ala Leu Leu Gly Asp Thr Gly Thr Gly Asp Phe Leu Lys Ala 
    50                  55                  60                  


Pro Gln Ser Phe Arg Ala Glu Leu Ser Ser Ile Leu Leu Leu Leu Phe 
65                  70                  75                  80  


Leu Tyr Val Leu Gln Gly Ile Pro Leu Gly Leu Ala Gly Ser Ile Pro 
                85                  90                  95      


Leu Ile Leu Gln Ser Lys Asn Val Ser Tyr Thr Asp Gln Ala Phe Phe 
            100                 105                 110         


Ser Phe Val Phe Trp Pro Phe Ser Leu Lys Leu Leu Trp Ala Pro Leu 
        115                 120                 125             


Val Asp Ala Val Tyr Val Lys Asn Phe Gly Arg Arg Lys Ser Trp Leu 
    130                 135                 140                 


Val Pro Thr Gln Tyr Ile Leu Gly Leu Phe Met Ile Tyr Leu Ser Thr 
145                 150                 155                 160 


Gln Val Asp Arg Leu Leu Gly Asn Thr Asp Asp Arg Thr Pro Asp Val 
                165                 170                 175     


Ile Ala Leu Thr Val Ala Phe Phe Leu Phe Glu Phe Leu Ala Ala Thr 
            180                 185                 190         


Gln Asp Ile Ala Val Asp Gly Trp Ala Leu Thr Met Leu Ser Arg Glu 
        195                 200                 205             


Asn Val Gly Tyr Ala Ser Thr Cys Asn Ser Val Gly Gln Thr Ala Gly 
    210                 215                 220                 


Tyr Phe Leu Gly Asn Val Leu Phe Leu Ala Leu Glu Ser Ala Asp Phe 
225                 230                 235                 240 


Cys Asn Lys Tyr Leu Arg Phe Gln Pro Gln Pro Arg Gly Ile Val Thr 
                245                 250                 255     


Leu Ser Asp Phe Leu Phe Phe Trp Gly Thr Val Phe Leu Ile Thr Thr 
            260                 265                 270         


Thr Leu Val Ala Leu Leu Lys Lys Glu Asn Glu Val Ser Val Val Lys 
        275                 280                 285             


Glu Glu Thr Gln Gly Ile Thr Asp Thr Tyr Lys Leu Leu Phe Ala Ile 
    290                 295                 300                 


Ile Lys Met Pro Ala Val Leu Thr Phe Cys Leu Leu Ile Leu Thr Ala 
305                 310                 315                 320 


Lys Ile Gly Phe Ser Ala Ala Asp Ala Val Thr Gly Leu Lys Leu Val 
                325                 330                 335     


Glu Glu Gly Val Pro Lys Glu His Leu Ala Leu Leu Ala Val Pro Met 
            340                 345                 350         


Val Pro Leu Gln Ile Ile Leu Pro Leu Ile Ile Ser Lys Tyr Thr Ala 
        355                 360                 365             


Gly Pro Gln Pro Leu Asn Thr Phe Tyr Lys Ala Met Pro Tyr Arg Leu 
    370                 375                 380                 


Leu Leu Gly Leu Glu Tyr Ala Leu Leu Val Trp Trp Thr Pro Lys Val 
385                 390                 395                 400 


Glu His Gln Gly Gly Phe Pro Ile Tyr Tyr Tyr Ile Val Val Leu Leu 
                405                 410                 415     


Ser Tyr Ala Leu His Gln Val Thr Val Tyr Ser Met Tyr Val Ser Ile 
            420                 425                 430         


Met Ala Phe Asn Ala Lys Val Ser Asp Pro Leu Ile Gly Gly Thr Tyr 
        435                 440                 445             


Met Thr Leu Leu Asn Thr Val Ser Asn Leu Gly Gly Asn Trp Pro Ser 
    450                 455                 460                 


Thr Val Ala Leu Trp Leu Val Asp Pro Leu Thr Val Lys Glu Cys Val 
465                 470                 475                 480 


Gly Ala Ser Asn Gln Asn Cys Arg Thr Pro Asp Ala Val Glu Leu Cys 
                485                 490                 495     


Lys Lys Leu Gly Gly Ser Cys Val Thr Ala Leu Asp Gly Tyr Tyr Val 
            500                 505                 510         


Glu Ser Ile Ile Cys Val Phe Ile Gly Phe Gly Trp Trp Phe Phe Leu 
        515                 520                 525             


Gly Pro Lys Phe Lys Lys Leu Gln Asp Glu Gly Ser Ser Ser Trp Lys 
    530                 535                 540                 


Cys Lys Arg Asn Asn 
545                 


<210>  3112
<211>  696
<212>  PRT
<213>  Homo sapiens

<400>  3112

Met Lys Phe Ala Glu His Leu Ser Ala His Ile Thr Pro Glu Trp Arg 
1               5                   10                  15      


Lys Gln Tyr Ile Gln Tyr Glu Ala Phe Lys Asp Met Leu Tyr Ser Ala 
            20                  25                  30          


Gln Asp Gln Ala Pro Ser Val Glu Val Thr Asp Glu Asp Thr Val Lys 
        35                  40                  45              


Arg Tyr Phe Ala Lys Phe Glu Glu Lys Phe Phe Gln Thr Cys Glu Lys 
    50                  55                  60                  


Glu Leu Ala Lys Ile Asn Thr Phe Tyr Ser Glu Lys Leu Ala Glu Ala 
65                  70                  75                  80  


Gln Arg Arg Phe Ala Thr Leu Gln Asn Glu Leu Gln Ser Ser Leu Asp 
                85                  90                  95      


Ala Gln Lys Glu Ser Thr Gly Val Thr Thr Leu Arg Gln Arg Arg Lys 
            100                 105                 110         


Pro Val Phe His Leu Ser His Glu Glu Arg Val Gln His Arg Asn Ile 
        115                 120                 125             


Lys Asp Leu Lys Leu Ala Phe Ser Glu Phe Tyr Leu Ser Leu Ile Leu 
    130                 135                 140                 


Leu Gln Asn Tyr Gln Asn Leu Asn Phe Thr Gly Phe Arg Lys Ile Leu 
145                 150                 155                 160 


Lys Lys His Asp Lys Ile Leu Glu Thr Ser Arg Gly Ala Asp Trp Arg 
                165                 170                 175     


Val Ala His Val Glu Val Ala Pro Phe Tyr Thr Cys Lys Lys Ile Asn 
            180                 185                 190         


Gln Leu Ile Ser Glu Thr Glu Ala Val Val Thr Asn Glu Leu Glu Asp 
        195                 200                 205             


Gly Asp Arg Gln Lys Ala Met Lys Arg Leu Arg Val Pro Pro Leu Gly 
    210                 215                 220                 


Ala Ala Gln Pro Ala Pro Ala Trp Thr Thr Phe Arg Val Gly Leu Phe 
225                 230                 235                 240 


Cys Gly Ile Phe Ile Val Leu Asn Ile Thr Leu Val Leu Ala Ala Val 
                245                 250                 255     


Phe Lys Leu Glu Thr Asp Arg Ser Ile Trp Pro Leu Ile Arg Ile Tyr 
            260                 265                 270         


Arg Gly Gly Phe Leu Leu Ile Glu Phe Leu Phe Leu Leu Gly Ile Asn 
        275                 280                 285             


Thr Tyr Gly Trp Arg Gln Ala Gly Val Asn His Val Leu Ile Phe Glu 
    290                 295                 300                 


Leu Asn Pro Arg Ser Asn Leu Ser His Gln His Leu Phe Glu Ile Ala 
305                 310                 315                 320 


Gly Phe Leu Gly Ile Leu Trp Cys Leu Ser Leu Leu Ala Cys Phe Phe 
                325                 330                 335     


Ala Pro Ile Ser Val Ile Pro Thr Tyr Val Tyr Pro Leu Ala Leu Tyr 
            340                 345                 350         


Gly Phe Met Val Phe Phe Leu Ile Asn Pro Thr Lys Thr Phe Tyr Tyr 
        355                 360                 365             


Lys Ser Arg Phe Trp Leu Leu Lys Leu Leu Phe Arg Val Phe Thr Ala 
    370                 375                 380                 


Pro Phe His Lys Val Gly Phe Ala Asp Phe Trp Leu Ala Asp Gln Leu 
385                 390                 395                 400 


Asn Ser Leu Ser Val Ile Leu Met Asp Leu Glu Tyr Met Ile Cys Phe 
                405                 410                 415     


Tyr Ser Leu Glu Leu Lys Trp Asp Glu Ser Lys Gly Leu Leu Pro Asn 
            420                 425                 430         


Asn Ser Glu Glu Ser Gly Ile Cys His Lys Tyr Thr Tyr Gly Val Arg 
        435                 440                 445             


Ala Ile Val Gln Cys Ile Pro Ala Trp Leu Arg Phe Ile Gln Cys Leu 
    450                 455                 460                 


Arg Arg Tyr Arg Asp Thr Lys Arg Ala Phe Pro His Leu Val Asn Ala 
465                 470                 475                 480 


Gly Lys Tyr Ser Thr Thr Phe Phe Met Val Thr Phe Ala Ala Leu Tyr 
                485                 490                 495     


Ser Thr His Lys Glu Arg Gly His Ser Asp Thr Met Val Phe Phe Tyr 
            500                 505                 510         


Leu Trp Ile Val Phe Tyr Ile Ile Ser Ser Cys Tyr Thr Leu Ile Trp 
        515                 520                 525             


Asp Leu Lys Met Asp Trp Gly Leu Phe Asp Lys Asn Ala Gly Glu Asn 
    530                 535                 540                 


Thr Phe Leu Arg Glu Glu Ile Val Tyr Pro Gln Lys Ala Tyr Tyr Tyr 
545                 550                 555                 560 


Cys Ala Ile Ile Glu Asp Val Ile Leu Arg Phe Ala Trp Thr Ile Gln 
                565                 570                 575     


Ile Ser Ile Thr Ser Thr Thr Leu Leu Pro His Ser Gly Asp Ile Ile 
            580                 585                 590         


Ala Thr Val Phe Ala Pro Leu Glu Val Phe Arg Arg Phe Val Trp Asn 
        595                 600                 605             


Phe Phe Arg Leu Glu Asn Glu His Leu Asn Asn Cys Gly Glu Phe Arg 
    610                 615                 620                 


Ala Val Arg Asp Ile Ser Val Ala Pro Leu Asn Ala Asp Asp Gln Thr 
625                 630                 635                 640 


Leu Leu Glu Gln Met Met Asp Gln Asp Asp Gly Val Arg Asn Arg Gln 
                645                 650                 655     


Lys Asn Arg Ser Trp Lys Tyr Asn Gln Ser Ile Ser Leu Arg Arg Pro 
            660                 665                 670         


Arg Leu Ala Ser Gln Ser Lys Ala Arg Asp Thr Lys Val Leu Ile Glu 
        675                 680                 685             


Asp Thr Asp Asp Glu Ala Asn Thr 
    690                 695     


<210>  3113
<211>  756
<212>  PRT
<213>  Homo sapiens

<400>  3113

Met Leu Gly Ile Cys Arg Gly Arg Arg Lys Phe Leu Ala Ala Ser Leu 
1               5                   10                  15      


Ser Leu Leu Cys Ile Pro Ala Ile Thr Trp Ile Tyr Leu Phe Ser Gly 
            20                  25                  30          


Ser Phe Glu Asp Gly Lys Pro Val Ser Leu Ser Pro Leu Glu Ser Gln 
        35                  40                  45              


Ala His Ser Pro Arg Tyr Thr Ala Ser Ser Gln Arg Glu Arg Glu Ser 
    50                  55                  60                  


Leu Glu Val Arg Met Arg Glu Val Glu Glu Glu Asn Arg Ala Leu Arg 
65                  70                  75                  80  


Arg Gln Leu Ser Leu Ala Gln Gly Arg Ala Pro Ser His Arg Arg Gly 
                85                  90                  95      


Asn His Ser Lys Thr Tyr Ser Met Glu Glu Gly Thr Gly Asp Ser Glu 
            100                 105                 110         


Asn Leu Arg Ala Gly Ile Val Ala Gly Asn Ser Ser Glu Cys Gly Gln 
        115                 120                 125             


Gln Pro Val Val Glu Lys Cys Glu Thr Ile His Val Ala Ile Val Cys 
    130                 135                 140                 


Ala Gly Tyr Asn Ala Ser Arg Asp Val Val Thr Leu Val Lys Ser Val 
145                 150                 155                 160 


Leu Phe His Arg Arg Asn Pro Leu His Phe His Leu Ile Ala Asp Ser 
                165                 170                 175     


Ile Ala Glu Gln Ile Leu Ala Thr Leu Phe Gln Thr Trp Met Val Pro 
            180                 185                 190         


Ala Val Arg Val Asp Phe Tyr Asn Ala Asp Glu Leu Lys Ser Glu Val 
        195                 200                 205             


Ser Trp Ile Pro Asn Lys His Tyr Ser Gly Ile Tyr Gly Leu Met Lys 
    210                 215                 220                 


Leu Val Leu Thr Lys Thr Leu Pro Ala Asn Leu Glu Arg Val Ile Val 
225                 230                 235                 240 


Leu Asp Thr Asp Ile Thr Phe Ala Thr Asp Ile Ala Glu Leu Trp Ala 
                245                 250                 255     


Val Phe His Lys Phe Lys Gly Gln Gln Val Leu Gly Leu Val Glu Asn 
            260                 265                 270         


Gln Ser Asp Trp Tyr Leu Gly Asn Leu Trp Lys Asn His Arg Pro Trp 
        275                 280                 285             


Pro Ala Leu Gly Arg Gly Tyr Asn Thr Gly Val Ile Leu Leu Leu Leu 
    290                 295                 300                 


Asp Lys Leu Arg Lys Met Lys Trp Glu Gln Met Trp Arg Leu Thr Ala 
305                 310                 315                 320 


Glu Arg Glu Leu Met Gly Met Leu Ser Thr Ser Leu Ala Asp Gln Asp 
                325                 330                 335     


Ile Phe Asn Ala Val Ile Lys Gln Asn Pro Phe Leu Val Tyr Gln Leu 
            340                 345                 350         


Pro Cys Phe Trp Asn Val Gln Leu Ser Asp His Thr Arg Ser Glu Gln 
        355                 360                 365             


Cys Tyr Arg Asp Val Ser Asp Leu Lys Val Ile His Trp Asn Ser Pro 
    370                 375                 380                 


Lys Lys Leu Arg Val Lys Asn Lys His Val Glu Phe Phe Arg Asn Leu 
385                 390                 395                 400 


Tyr Leu Thr Phe Leu Glu Tyr Asp Gly Asn Leu Leu Arg Arg Glu Leu 
                405                 410                 415     


Phe Gly Cys Pro Ser Glu Ala Asp Val Asn Ser Glu Asn Leu Gln Lys 
            420                 425                 430         


Gln Leu Ser Glu Leu Asp Glu Asp Asp Leu Cys Tyr Glu Phe Arg Arg 
        435                 440                 445             


Glu Arg Phe Thr Val His Arg Thr His Leu Tyr Phe Leu His Tyr Glu 
    450                 455                 460                 


Tyr Glu Pro Ala Ala Asp Ser Thr Asp Val Thr Leu Val Ala Gln Leu 
465                 470                 475                 480 


Ser Met Asp Arg Leu Gln Met Leu Glu Ala Ile Cys Lys His Trp Glu 
                485                 490                 495     


Gly Pro Ile Ser Leu Ala Leu Tyr Leu Ser Asp Ala Glu Ala Gln Gln 
            500                 505                 510         


Phe Leu Arg Tyr Ala Gln Gly Ser Glu Val Leu Met Ser Arg His Asn 
        515                 520                 525             


Val Gly Tyr His Ile Val Tyr Lys Glu Gly Gln Phe Tyr Pro Val Asn 
    530                 535                 540                 


Leu Leu Arg Asn Val Ala Met Lys His Ile Ser Thr Pro Tyr Met Phe 
545                 550                 555                 560 


Leu Ser Asp Ile Asp Phe Leu Pro Met Tyr Gly Leu Tyr Glu Tyr Leu 
                565                 570                 575     


Arg Lys Ser Val Ile Gln Leu Asp Leu Ala Asn Thr Lys Lys Ala Met 
            580                 585                 590         


Ile Val Pro Ala Phe Glu Thr Leu Arg Tyr Arg Leu Ser Phe Pro Lys 
        595                 600                 605             


Ser Lys Ala Glu Leu Leu Ser Met Leu Asp Met Gly Thr Leu Phe Thr 
    610                 615                 620                 


Phe Arg Tyr His Val Trp Thr Lys Gly His Ala Pro Thr Asn Phe Ala 
625                 630                 635                 640 


Lys Trp Arg Thr Ala Thr Thr Pro Tyr Arg Val Glu Trp Glu Ala Asp 
                645                 650                 655     


Phe Glu Pro Tyr Val Val Val Arg Arg Asp Cys Pro Glu Tyr Asp Arg 
            660                 665                 670         


Arg Phe Val Gly Phe Gly Trp Asn Lys Val Ala His Ile Met Glu Leu 
        675                 680                 685             


Asp Val Gln Glu Tyr Glu Phe Ile Val Leu Pro Asn Ala Tyr Met Ile 
    690                 695                 700                 


His Met Pro His Ala Pro Ser Phe Asp Ile Thr Lys Phe Arg Ser Asn 
705                 710                 715                 720 


Lys Gln Tyr Arg Ile Cys Leu Lys Thr Leu Lys Glu Glu Phe Gln Gln 
                725                 730                 735     


Asp Met Ser Arg Arg Tyr Gly Phe Ala Ala Leu Lys Tyr Leu Thr Ala 
            740                 745                 750         


Glu Asn Asn Ser 
        755     


<210>  3114
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  3114

Met Ala Lys Val Glu Gln Val Leu Ser Leu Glu Pro Gln His Glu Leu 
1               5                   10                  15      


Lys Phe Arg Gly Pro Phe Thr Asp Val Val Thr Thr Asn Leu Lys Leu 
            20                  25                  30          


Gly Asn Pro Thr Asp Arg Asn Val Cys Phe Lys Val Lys Thr Thr Ala 
        35                  40                  45              


Pro Arg Arg Tyr Cys Val Arg Pro Asn Ser Gly Ile Ile Asp Ala Gly 
    50                  55                  60                  


Ala Ser Ile Asn Val Ser Val Met Leu Gln Pro Phe Asp Tyr Asp Pro 
65                  70                  75                  80  


Asn Glu Lys Ser Lys His Lys Phe Met Val Gln Ser Met Phe Ala Pro 
                85                  90                  95      


Thr Asp Thr Ser Asp Met Glu Ala Val Trp Lys Glu Ala Lys Pro Glu 
            100                 105                 110         


Asp Leu Met Asp Ser Lys Leu Arg Cys Val Phe Glu Leu Pro Ala Glu 
        115                 120                 125             


Asn Asp Lys Pro His Asp Val Glu Ile Asn Lys Ile Ile Ser Thr Thr 
    130                 135                 140                 


Ala Ser Lys Thr Glu Thr Pro Ile Val Ser Lys Ser Leu Ser Ser Ser 
145                 150                 155                 160 


Leu Asp Asp Thr Glu Val Lys Lys Val Met Glu Glu Cys Lys Arg Leu 
                165                 170                 175     


Gln Gly Glu Val Gln Arg Leu Arg Glu Glu Asn Lys Gln Phe Lys Glu 
            180                 185                 190         


Glu Asp Gly Leu Arg Met Arg Lys Thr Val Gln Ser Asn Ser Pro Ile 
        195                 200                 205             


Ser Ala Leu Ala Pro Thr Gly Lys Glu Glu Gly Leu Ser Thr Arg Leu 
    210                 215                 220                 


Leu Ala Leu Val Val Leu Phe Phe Ile Val Gly Val Ile Ile Gly Lys 
225                 230                 235                 240 


Ile Ala Leu 
            


<210>  3115
<211>  757
<212>  PRT
<213>  Homo sapiens

<400>  3115

Met Ser Glu Asn Ser Ser Asp Ser Asp Ser Ser Cys Gly Trp Thr Val 
1               5                   10                  15      


Ile Ser His Glu Gly Ser Asp Ile Glu Met Leu Asn Ser Val Thr Pro 
            20                  25                  30          


Thr Asp Ser Cys Glu Pro Ala Pro Glu Cys Ser Ser Leu Glu Gln Glu 
        35                  40                  45              


Glu Leu Gln Ala Leu Gln Ile Glu Gln Gly Glu Ser Ser Gln Asn Gly 
    50                  55                  60                  


Thr Val Leu Met Glu Glu Thr Ala Tyr Pro Ala Leu Glu Glu Thr Ser 
65                  70                  75                  80  


Ser Thr Ile Glu Ala Glu Glu Gln Lys Ile Pro Glu Asp Ser Ile Tyr 
                85                  90                  95      


Ile Gly Thr Ala Ser Asp Asp Ser Asp Ile Val Thr Leu Glu Pro Pro 
            100                 105                 110         


Lys Leu Glu Glu Ile Gly Asn Gln Glu Val Val Ile Val Glu Glu Ala 
        115                 120                 125             


Gln Ser Ser Glu Asp Phe Asn Met Gly Ser Ser Ser Ser Ser Gln Tyr 
    130                 135                 140                 


Thr Phe Cys Gln Pro Glu Thr Val Phe Ser Ser Gln Pro Ser Asp Asp 
145                 150                 155                 160 


Glu Ser Ser Ser Asp Glu Thr Ser Asn Gln Pro Ser Pro Ala Phe Arg 
                165                 170                 175     


Arg Arg Arg Ala Arg Lys Lys Thr Val Ser Ala Ser Glu Ser Glu Asp 
            180                 185                 190         


Arg Leu Val Ala Glu Gln Glu Thr Glu Pro Ser Lys Glu Leu Ser Lys 
        195                 200                 205             


Arg Gln Phe Ser Ser Gly Leu Asn Lys Cys Val Ile Leu Ala Leu Val 
    210                 215                 220                 


Ile Ala Ile Ser Met Gly Phe Gly His Phe Tyr Gly Thr Ile Gln Ile 
225                 230                 235                 240 


Gln Lys Arg Gln Gln Leu Val Arg Lys Ile His Glu Asp Glu Leu Asn 
                245                 250                 255     


Asp Met Lys Asp Tyr Leu Ser Gln Cys Gln Gln Glu Gln Glu Ser Phe 
            260                 265                 270         


Ile Asp Tyr Lys Ser Leu Lys Glu Asn Leu Ala Arg Cys Trp Thr Leu 
        275                 280                 285             


Thr Glu Ala Glu Lys Met Ser Phe Glu Thr Gln Lys Thr Asn Leu Ala 
    290                 295                 300                 


Thr Glu Asn Gln Tyr Leu Arg Val Ser Leu Glu Lys Glu Glu Lys Ala 
305                 310                 315                 320 


Leu Ser Ser Leu Gln Glu Glu Leu Asn Lys Leu Arg Glu Gln Ile Arg 
                325                 330                 335     


Ile Leu Glu Asp Lys Gly Thr Ser Thr Glu Leu Val Lys Glu Asn Gln 
            340                 345                 350         


Lys Leu Lys Gln His Leu Glu Glu Glu Lys Gln Lys Lys His Ser Phe 
        355                 360                 365             


Leu Ser Gln Arg Glu Thr Leu Leu Thr Glu Ala Lys Met Leu Lys Arg 
    370                 375                 380                 


Glu Leu Glu Arg Glu Arg Leu Val Thr Thr Ala Leu Arg Gly Glu Leu 
385                 390                 395                 400 


Gln Gln Leu Ser Gly Ser Gln Leu His Gly Lys Ser Asp Ser Pro Asn 
                405                 410                 415     


Val Tyr Thr Glu Lys Lys Glu Ile Ala Ile Leu Arg Glu Arg Leu Thr 
            420                 425                 430         


Glu Leu Glu Arg Lys Leu Thr Phe Glu Gln Gln Arg Ser Asp Leu Trp 
        435                 440                 445             


Glu Arg Leu Tyr Val Glu Ala Lys Asp Gln Asn Gly Lys Gln Gly Thr 
    450                 455                 460                 


Asp Gly Lys Lys Lys Gly Gly Arg Gly Ser His Arg Ala Lys Asn Lys 
465                 470                 475                 480 


Ser Lys Glu Thr Phe Leu Gly Ser Val Lys Glu Thr Phe Asp Ala Met 
                485                 490                 495     


Lys Asn Ser Thr Lys Glu Phe Val Arg His His Lys Glu Lys Ile Lys 
            500                 505                 510         


Gln Ala Lys Glu Ala Val Lys Glu Asn Leu Lys Lys Phe Ser Asp Ser 
        515                 520                 525             


Val Lys Ser Thr Phe Arg His Phe Lys Asp Thr Thr Lys Asn Ile Phe 
    530                 535                 540                 


Asp Glu Lys Gly Asn Lys Arg Phe Gly Ala Thr Lys Glu Ala Ala Glu 
545                 550                 555                 560 


Lys Pro Arg Thr Val Phe Ser Asp Tyr Leu His Pro Gln Tyr Lys Ala 
                565                 570                 575     


Pro Thr Glu Asn His His Asn Arg Gly Pro Thr Met Gln Asn Asp Gly 
            580                 585                 590         


Arg Lys Glu Lys Pro Val His Phe Lys Glu Phe Arg Lys Asn Thr Asn 
        595                 600                 605             


Ser Lys Lys Cys Ser Pro Gly His Asp Cys Arg Glu Asn Ser His Ser 
    610                 615                 620                 


Phe Arg Lys Ala Cys Ser Gly Val Phe Asp Cys Ala Gln Gln Glu Ser 
625                 630                 635                 640 


Met Ser Leu Phe Asn Thr Val Val Asn Pro Ile Arg Met Asp Glu Phe 
                645                 650                 655     


Arg Gln Ile Ile Gln Arg Tyr Met Leu Lys Glu Leu Asp Thr Phe Cys 
            660                 665                 670         


His Trp Asn Glu Leu Asp Gln Phe Ile Asn Lys Phe Phe Leu Asn Gly 
        675                 680                 685             


Val Phe Ile His Asp Gln Lys Leu Phe Thr Asp Phe Val Asn Asp Val 
    690                 695                 700                 


Lys Asp Tyr Leu Arg Asn Met Lys Glu Tyr Glu Val Asp Asn Asp Gly 
705                 710                 715                 720 


Val Phe Glu Lys Leu Asp Glu Tyr Ile Tyr Arg His Phe Phe Gly His 
                725                 730                 735     


Thr Phe Ser Pro Pro Tyr Gly Pro Arg Ser Val Tyr Ile Lys Pro Cys 
            740                 745                 750         


His Tyr Ser Ser Leu 
        755         


<210>  3116
<211>  438
<212>  PRT
<213>  Homo sapiens

<400>  3116

Met Val Gln Trp Lys Arg Leu Cys Gln Leu His Tyr Leu Trp Ala Leu 
1               5                   10                  15      


Gly Cys Tyr Met Leu Leu Ala Thr Val Ala Leu Lys Leu Ser Phe Arg 
            20                  25                  30          


Leu Lys Cys Asp Ser Asp His Leu Gly Leu Glu Ser Arg Glu Ser Gln 
        35                  40                  45              


Ser Gln Tyr Cys Arg Asn Ile Leu Tyr Asn Phe Leu Lys Leu Pro Ala 
    50                  55                  60                  


Lys Arg Ser Ile Asn Cys Ser Gly Val Thr Arg Gly Asp Gln Glu Ala 
65                  70                  75                  80  


Val Leu Gln Ala Ile Leu Asn Asn Leu Glu Val Lys Lys Lys Arg Glu 
                85                  90                  95      


Pro Phe Thr Asp Thr His Tyr Leu Ser Leu Thr Arg Asp Cys Glu His 
            100                 105                 110         


Phe Lys Ala Glu Arg Lys Phe Ile Gln Phe Pro Leu Ser Lys Glu Glu 
        115                 120                 125             


Val Glu Phe Pro Ile Ala Tyr Ser Met Val Ile His Glu Lys Ile Glu 
    130                 135                 140                 


Asn Phe Glu Arg Leu Leu Arg Ala Val Tyr Ala Pro Gln Asn Ile Tyr 
145                 150                 155                 160 


Cys Val His Val Asp Glu Lys Ser Pro Glu Thr Phe Lys Glu Ala Val 
                165                 170                 175     


Lys Ala Ile Ile Ser Cys Phe Pro Asn Val Phe Ile Ala Ser Lys Leu 
            180                 185                 190         


Val Arg Val Val Tyr Ala Ser Trp Ser Arg Val Gln Ala Asp Leu Asn 
        195                 200                 205             


Cys Met Glu Asp Leu Leu Gln Ser Ser Val Pro Trp Lys Tyr Phe Leu 
    210                 215                 220                 


Asn Thr Cys Gly Thr Asp Phe Pro Ile Lys Ser Asn Ala Glu Met Val 
225                 230                 235                 240 


Gln Ala Leu Lys Met Leu Asn Gly Arg Asn Ser Met Glu Ser Glu Val 
                245                 250                 255     


Pro Pro Lys His Lys Glu Thr Arg Trp Lys Tyr His Phe Glu Val Val 
            260                 265                 270         


Arg Asp Thr Leu His Leu Thr Asn Lys Lys Lys Asp Pro Pro Pro Tyr 
        275                 280                 285             


Asn Leu Thr Met Phe Thr Gly Asn Ala Tyr Ile Val Ala Ser Arg Asp 
    290                 295                 300                 


Phe Val Gln His Val Leu Lys Asn Pro Lys Ser Gln Gln Leu Ile Glu 
305                 310                 315                 320 


Trp Val Lys Asp Thr Tyr Ser Pro Asp Glu His Leu Trp Ala Thr Leu 
                325                 330                 335     


Gln Arg Ala Arg Trp Met Pro Gly Ser Val Pro Asn His Pro Lys Tyr 
            340                 345                 350         


Asp Ile Ser Asp Met Thr Ser Ile Ala Arg Leu Val Lys Trp Gln Gly 
        355                 360                 365             


His Glu Gly Asp Ile Asp Lys Gly Ala Pro Tyr Ala Pro Cys Ser Gly 
    370                 375                 380                 


Ile His Gln Arg Ala Ile Cys Val Tyr Gly Ala Gly Asp Leu Asn Trp 
385                 390                 395                 400 


Met Leu Gln Asn His His Leu Leu Ala Asn Lys Phe Asp Pro Lys Val 
                405                 410                 415     


Asp Asp Asn Ala Leu Gln Cys Leu Glu Glu Tyr Leu Arg Tyr Lys Ala 
            420                 425                 430         


Ile Tyr Gly Thr Glu Leu 
        435             


<210>  3117
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  3117

Met Val Trp Lys Arg Leu Gly Ala Leu Val Met Phe Pro Leu Gln Met 
1               5                   10                  15      


Ile Tyr Leu Val Val Lys Ala Ala Val Gly Leu Val Leu Pro Ala Lys 
            20                  25                  30          


Leu Arg Asp Leu Ser Arg Glu Asn Val Leu Ile Thr Gly Gly Gly Arg 
        35                  40                  45              


Gly Ile Gly Arg Gln Leu Ala Arg Glu Phe Ala Glu Arg Gly Ala Arg 
    50                  55                  60                  


Lys Ile Val Leu Trp Gly Arg Thr Glu Lys Cys Leu Lys Glu Thr Thr 
65                  70                  75                  80  


Glu Glu Ile Arg Gln Met Gly Thr Glu Cys His Tyr Phe Ile Cys Asp 
                85                  90                  95      


Val Gly Asn Arg Glu Glu Val Tyr Gln Thr Ala Lys Ala Val Arg Glu 
            100                 105                 110         


Lys Val Gly Asp Ile Thr Ile Leu Val Asn Asn Ala Ala Val Val His 
        115                 120                 125             


Gly Lys Ser Leu Met Asp Ser Asp Asp Asp Ala Leu Leu Lys Ser Gln 
    130                 135                 140                 


His Ile Asn Thr Leu Gly Gln Phe Trp Thr Thr Lys Ala Phe Leu Pro 
145                 150                 155                 160 


Arg Met Leu Glu Leu Gln Asn Gly His Ile Val Cys Leu Asn Ser Val 
                165                 170                 175     


Leu Ala Leu Ser Ala Ile Pro Gly Ala Ile Asp Tyr Cys Thr Ser Lys 
            180                 185                 190         


Ala Ser Ala Phe Ala Phe Met Glu Ser Leu Thr Leu Gly Leu Leu Asp 
        195                 200                 205             


Cys Pro Gly Val Ser Ala Thr Thr Val Leu Pro Phe His Thr Ser Thr 
    210                 215                 220                 


Glu Met Phe Gln Gly Met Arg Val Arg Phe Pro Asn Leu Phe Pro Pro 
225                 230                 235                 240 


Leu Lys Pro Glu Thr Val Ala Arg Arg Thr Val Glu Ala Val Gln Leu 
                245                 250                 255     


Asn Gln Ala Leu Leu Leu Leu Pro Trp Thr Met His Ala Leu Val Ile 
            260                 265                 270         


Leu Lys Ser Ile Leu Pro Gln Ala Ala Leu Glu Glu Ile His Lys Phe 
        275                 280                 285             


Ser Gly Thr Tyr Thr Cys Met Asn Thr Phe Lys Gly Arg Thr 
    290                 295                 300         


<210>  3118
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  3118

Met Arg Trp Leu Trp Pro Leu Ala Val Ser Leu Ala Val Ile Leu Ala 
1               5                   10                  15      


Val Gly Leu Ser Arg Val Ser Gly Gly Ala Pro Leu His Leu Gly Arg 
            20                  25                  30          


His Arg Ala Glu Thr Gln Glu Gln Gln Ser Arg Ser Lys Arg Gly Thr 
        35                  40                  45              


Glu Asp Glu Glu Ala Lys Gly Val Gln Gln Tyr Val Pro Glu Glu Trp 
    50                  55                  60                  


Ala Glu Tyr Pro Arg Pro Ile His Pro Ala Gly Leu Gln Pro Thr Lys 
65                  70                  75                  80  


Pro Leu Val Ala Thr Ser Pro Asn Pro Gly Lys Asp Gly Gly Thr Pro 
                85                  90                  95      


Asp Ser Gly Gln Glu Leu Arg Gly Asn Leu Thr Gly Ala Pro Gly Gln 
            100                 105                 110         


Arg Leu Gln Ile Gln Asn Pro Leu Tyr Pro Val Thr Glu Ser Ser Tyr 
        115                 120                 125             


Ser Ala Tyr Ala Ile Met Leu Leu Ala Leu Val Val Phe Ala Val Gly 
    130                 135                 140                 


Ile Val Gly Asn Leu Ser Val Met Cys Ile Val Trp His Ser Tyr Tyr 
145                 150                 155                 160 


Leu Lys Ser Ala Trp Asn Ser Ile Leu Ala Ser Leu Ala Leu Trp Asp 
                165                 170                 175     


Phe Leu Val Leu Phe Phe Cys Leu Pro Ile Val Ile Phe Asn Glu Ile 
            180                 185                 190         


Thr Lys Gln Arg Leu Leu Gly Asp Val Ser Cys Arg Ala Val Pro Phe 
        195                 200                 205             


Met Glu Val Ser Ser Leu Gly Val Thr Thr Phe Ser Leu Cys Ala Leu 
    210                 215                 220                 


Gly Ile Asp Arg Phe His Val Ala Thr Ser Thr Leu Pro Lys Val Arg 
225                 230                 235                 240 


Pro Ile Glu Arg Cys Gln Ser Ile Leu Ala Lys Leu Ala Val Ile Trp 
                245                 250                 255     


Val Gly Ser Met Thr Leu Ala Val Pro Glu Leu Leu Leu Trp Gln Leu 
            260                 265                 270         


Ala Gln Glu Pro Ala Pro Thr Met Gly Thr Leu Asp Ser Cys Ile Met 
        275                 280                 285             


Lys Pro Ser Ala Ser Leu Pro Glu Ser Leu Tyr Ser Leu Val Met Thr 
    290                 295                 300                 


Tyr Gln Asn Ala Arg Met Trp Trp Tyr Phe Gly Cys Tyr Phe Cys Leu 
305                 310                 315                 320 


Pro Ile Leu Phe Thr Val Thr Cys Gln Leu Val Thr Trp Arg Val Arg 
                325                 330                 335     


Gly Pro Pro Gly Arg Lys Ser Glu Cys Arg Ala Ser Lys His Glu Gln 
            340                 345                 350         


Cys Glu Ser Gln Leu Asn Ser Thr Val Val Gly Leu Thr Val Val Tyr 
        355                 360                 365             


Ala Phe Cys Thr Leu Pro Glu Asn Val Cys Asn Ile Val Val Ala Tyr 
    370                 375                 380                 


Leu Ser Thr Glu Leu Thr Arg Gln Thr Leu Asp Leu Leu Gly Leu Ile 
385                 390                 395                 400 


Asn Gln Phe Ser Thr Phe Phe Lys Gly Ala Ile Thr Pro Val Leu Leu 
                405                 410                 415     


Leu Cys Ile Cys Arg Pro Leu Gly Gln Ala Phe Leu Asp Cys Cys Cys 
            420                 425                 430         


Cys Cys Cys Cys Glu Glu Cys Gly Gly Ala Ser Glu Ala Ser Ala Ala 
        435                 440                 445             


Asn Gly Ser Asp Asn Lys Leu Lys Thr Glu Val Ser Ser Ser Ile Tyr 
    450                 455                 460                 


Phe His Lys Pro Arg Glu Ser Pro Pro Leu Leu Pro Leu Gly Thr Pro 
465                 470                 475                 480 


Cys 
    


<210>  3119
<211>  911
<212>  PRT
<213>  Homo sapiens

<400>  3119

Met Ala Glu Lys Ala Pro Pro Gly Leu Asn Arg Lys Thr Ser Arg Ser 
1               5                   10                  15      


Thr Leu Ser Leu Pro Pro Glu Pro Val Asp Ile Ile Arg Ser Lys Thr 
            20                  25                  30          


Cys Ser Arg Arg Val Lys Ile Asn Val Gly Gly Leu Asn His Glu Val 
        35                  40                  45              


Leu Trp Arg Thr Leu Asp Arg Leu Pro Arg Thr Arg Leu Gly Lys Leu 
    50                  55                  60                  


Arg Asp Cys Asn Thr His Glu Ser Leu Leu Glu Val Cys Asp Asp Tyr 
65                  70                  75                  80  


Asn Leu Asn Glu Asn Glu Tyr Phe Phe Asp Arg His Pro Gly Ala Phe 
                85                  90                  95      


Thr Ser Ile Leu Asn Phe Tyr Arg Thr Gly Lys Leu His Met Met Glu 
            100                 105                 110         


Glu Met Cys Ala Leu Ser Phe Gly Gln Glu Leu Asp Tyr Trp Gly Ile 
        115                 120                 125             


Asp Glu Ile Tyr Leu Glu Ser Cys Cys Gln Ala Arg Tyr His Gln Lys 
    130                 135                 140                 


Lys Glu Gln Met Asn Glu Glu Leu Arg Arg Glu Ala Glu Thr Met Arg 
145                 150                 155                 160 


Glu Arg Glu Gly Glu Glu Phe Asp Asn Thr Cys Cys Pro Asp Lys Arg 
                165                 170                 175     


Lys Lys Leu Trp Asp Leu Leu Glu Lys Pro Asn Ser Ser Val Ala Ala 
            180                 185                 190         


Lys Ile Leu Ala Ile Val Ser Ile Leu Phe Ile Val Leu Ser Thr Ile 
        195                 200                 205             


Ala Leu Ser Leu Asn Thr Leu Pro Glu Leu Gln Glu Thr Asp Glu Phe 
    210                 215                 220                 


Gly Gln Leu Asn Asp Asn Arg Gln Leu Ala His Val Glu Ala Val Cys 
225                 230                 235                 240 


Ile Ala Trp Phe Thr Met Glu Tyr Leu Leu Arg Phe Leu Ser Ser Pro 
                245                 250                 255     


Asn Lys Trp Lys Phe Phe Lys Gly Pro Leu Asn Val Ile Asp Leu Leu 
            260                 265                 270         


Ala Ile Leu Pro Tyr Tyr Val Thr Ile Phe Leu Thr Glu Ser Asn Lys 
        275                 280                 285             


Ser Val Leu Gln Phe Gln Asn Val Arg Arg Val Val Gln Ile Phe Arg 
    290                 295                 300                 


Ile Met Arg Ile Leu Arg Ile Leu Lys Leu Ala Arg His Ser Thr Gly 
305                 310                 315                 320 


Leu Gln Ser Leu Gly Phe Thr Leu Arg Arg Ser Tyr Asn Glu Leu Gly 
                325                 330                 335     


Leu Leu Ile Leu Phe Leu Ala Met Gly Ile Met Ile Phe Ser Ser Leu 
            340                 345                 350         


Val Phe Phe Ala Glu Lys Asp Glu Asp Ala Thr Lys Phe Thr Ser Ile 
        355                 360                 365             


Pro Ala Ser Phe Trp Trp Ala Thr Ile Thr Met Thr Thr Val Gly Tyr 
    370                 375                 380                 


Gly Asp Ile Tyr Pro Lys Thr Leu Leu Gly Lys Ile Val Gly Gly Leu 
385                 390                 395                 400 


Cys Cys Ile Ala Gly Val Leu Val Ile Ala Leu Pro Ile Pro Ile Ile 
                405                 410                 415     


Val Asn Asn Phe Ser Glu Phe Tyr Lys Glu Gln Lys Arg Gln Glu Lys 
            420                 425                 430         


Ala Ile Lys Arg Arg Glu Ala Leu Glu Arg Ala Lys Arg Asn Gly Ser 
        435                 440                 445             


Ile Val Ser Met Asn Leu Lys Asp Ala Phe Ala Arg Ser Met Glu Leu 
    450                 455                 460                 


Ile Asp Val Ala Val Glu Lys Ala Gly Glu Ser Ala Asn Thr Lys Asp 
465                 470                 475                 480 


Ser Ala Asp Asp Asn His Leu Ser Pro Ser Arg Trp Lys Trp Ala Arg 
                485                 490                 495     


Lys Ala Leu Ser Glu Thr Ser Ser Asn Lys Ser Phe Glu Asn Lys Tyr 
            500                 505                 510         


Gln Glu Val Ser Gln Lys Asp Ser His Glu Gln Leu Asn Asn Thr Ser 
        515                 520                 525             


Ser Ser Ser Pro Gln His Leu Ser Ala Gln Lys Leu Glu Met Leu Tyr 
    530                 535                 540                 


Asn Glu Ile Thr Lys Thr Gln Pro His Ser His Pro Asn Pro Asp Cys 
545                 550                 555                 560 


Gln Glu Lys Pro Glu Arg Pro Ser Ala Tyr Glu Glu Glu Ile Glu Met 
                565                 570                 575     


Glu Glu Val Val Cys Pro Gln Glu Gln Leu Ala Val Ala Gln Thr Glu 
            580                 585                 590         


Val Ile Val Asp Met Lys Ser Thr Ser Ser Ile Asp Ser Phe Thr Ser 
        595                 600                 605             


Cys Ala Thr Asp Phe Thr Glu Thr Glu Arg Ser Pro Leu Pro Pro Pro 
    610                 615                 620                 


Ser Ala Ser His Leu Gln Met Lys Phe Pro Thr Asp Leu Pro Gly Thr 
625                 630                 635                 640 


Glu Glu His Gln Arg Ala Arg Gly Pro Pro Phe Leu Thr Leu Ser Arg 
                645                 650                 655     


Glu Lys Gly Pro Ala Ala Arg Asp Gly Thr Leu Glu Tyr Ala Pro Val 
            660                 665                 670         


Asp Ile Thr Val Asn Leu Asp Ala Ser Gly Ser Gln Cys Gly Leu His 
        675                 680                 685             


Ser Pro Leu Gln Ser Asp Asn Ala Thr Asp Ser Pro Lys Ser Ser Leu 
    690                 695                 700                 


Lys Gly Ser Asn Pro Leu Lys Ser Arg Ser Leu Lys Val Asn Phe Lys 
705                 710                 715                 720 


Glu Asn Arg Gly Ser Ala Pro Gln Thr Pro Pro Ser Thr Ala Arg Pro 
                725                 730                 735     


Leu Pro Val Thr Thr Ala Asp Phe Ser Leu Thr Thr Pro Gln His Ile 
            740                 745                 750         


Ser Thr Ile Leu Leu Glu Glu Thr Pro Ser Gln Gly Asp Arg Pro Leu 
        755                 760                 765             


Leu Gly Thr Glu Val Ser Ala Pro Cys Gln Gly Pro Ser Lys Gly Leu 
    770                 775                 780                 


Ser Pro Arg Phe Pro Lys Gln Lys Leu Phe Pro Phe Ser Ser Arg Glu 
785                 790                 795                 800 


Arg Arg Ser Phe Thr Glu Ile Asp Thr Gly Asp Asp Glu Asp Phe Leu 
                805                 810                 815     


Glu Leu Pro Gly Ala Arg Glu Glu Lys Gln Val Asp Ser Ser Pro Asn 
            820                 825                 830         


Cys Phe Ala Asp Lys Pro Ser Asp Gly Arg Asp Pro Leu Arg Glu Glu 
        835                 840                 845             


Gly Ser Val Gly Ser Ser Ser Pro Gln Asp Thr Gly His Asn Cys Arg 
    850                 855                 860                 


Gln Asp Ile Tyr His Ala Val Ser Glu Val Lys Lys Asp Ser Ser Gln 
865                 870                 875                 880 


Glu Gly Cys Lys Met Glu Asn His Leu Phe Ala Pro Glu Ile His Ser 
                885                 890                 895     


Asn Pro Gly Asp Thr Gly Tyr Cys Pro Thr Arg Glu Thr Ser Met 
            900                 905                 910     


<210>  3120
<211>  483
<212>  PRT
<213>  Homo sapiens

<400>  3120

Met Lys Val Leu Pro Ala Ser Gly Leu Ala Val Phe Leu Ile Met Ala 
1               5                   10                  15      


Leu Lys Phe Ser Thr Ala Ala Pro Ser Leu Val Ala Ala Ser Pro Arg 
            20                  25                  30          


Thr Trp Arg Asn Asn Tyr Arg Leu Ala Gln Ala Tyr Leu Asp Lys Tyr 
        35                  40                  45              


Tyr Thr Asn Lys Glu Gly His Gln Ile Gly Glu Met Val Ala Arg Gly 
    50                  55                  60                  


Ser Asn Ser Met Ile Arg Lys Ile Lys Glu Leu Gln Ala Phe Phe Gly 
65                  70                  75                  80  


Leu Gln Val Thr Gly Lys Leu Asp Gln Thr Thr Met Asn Val Ile Lys 
                85                  90                  95      


Lys Pro Arg Cys Gly Val Pro Asp Val Ala Asn Tyr Arg Leu Phe Pro 
            100                 105                 110         


Gly Glu Pro Lys Trp Lys Lys Asn Thr Leu Thr Tyr Arg Ile Ser Lys 
        115                 120                 125             


Tyr Thr Pro Ser Met Ser Ser Val Glu Val Asp Lys Ala Val Glu Met 
    130                 135                 140                 


Ala Leu Gln Ala Trp Ser Ser Ala Val Pro Leu Ser Phe Val Arg Ile 
145                 150                 155                 160 


Asn Ser Gly Glu Ala Asp Ile Met Ile Ser Phe Glu Asn Gly Asp His 
                165                 170                 175     


Gly Asp Ser Tyr Pro Phe Asp Gly Pro Arg Gly Thr Leu Ala His Ala 
            180                 185                 190         


Phe Ala Pro Gly Glu Gly Leu Gly Gly Asp Thr His Phe Asp Asn Ala 
        195                 200                 205             


Glu Lys Trp Thr Met Gly Thr Asn Gly Phe Asn Leu Phe Thr Val Ala 
    210                 215                 220                 


Ala His Glu Phe Gly His Ala Leu Gly Leu Ala His Ser Thr Asp Pro 
225                 230                 235                 240 


Ser Ala Leu Met Tyr Pro Thr Tyr Lys Tyr Lys Asn Pro Tyr Gly Phe 
                245                 250                 255     


His Leu Pro Lys Asp Asp Val Lys Gly Ile Gln Ala Leu Tyr Gly Pro 
            260                 265                 270         


Arg Lys Val Phe Leu Gly Lys Pro Thr Leu Pro His Ala Pro His His 
        275                 280                 285             


Lys Pro Ser Ile Pro Asp Leu Cys Asp Ser Ser Ser Ser Phe Asp Ala 
    290                 295                 300                 


Val Thr Met Leu Gly Lys Glu Leu Leu Leu Phe Lys Asp Arg Ile Phe 
305                 310                 315                 320 


Trp Arg Arg Gln Val His Leu Arg Thr Gly Ile Arg Pro Ser Thr Ile 
                325                 330                 335     


Thr Ser Ser Phe Pro Gln Leu Met Ser Asn Val Asp Ala Ala Tyr Glu 
            340                 345                 350         


Val Ala Glu Arg Gly Thr Ala Tyr Phe Phe Lys Gly Pro His Tyr Trp 
        355                 360                 365             


Ile Thr Arg Gly Phe Gln Met Gln Gly Pro Pro Arg Thr Ile Tyr Asp 
    370                 375                 380                 


Phe Gly Phe Pro Arg His Val Gln Gln Ile Asp Ala Ala Val Tyr Leu 
385                 390                 395                 400 


Arg Glu Pro Gln Lys Thr Leu Phe Phe Val Gly Asp Glu Tyr Tyr Ser 
                405                 410                 415     


Tyr Asp Glu Arg Lys Arg Lys Met Glu Lys Asp Tyr Pro Lys Asn Thr 
            420                 425                 430         


Glu Glu Glu Phe Ser Gly Val Asn Gly Gln Ile Asp Ala Ala Val Glu 
        435                 440                 445             


Leu Asn Gly Tyr Ile Tyr Phe Phe Ser Gly Pro Lys Thr Tyr Lys Tyr 
    450                 455                 460                 


Asp Thr Glu Lys Glu Asp Val Val Ser Val Val Lys Ser Ser Ser Trp 
465                 470                 475                 480 


Ile Gly Cys 
            


<210>  3121
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  3121

Met Ser Val Leu Arg Arg Met Met Arg Val Ser Asn Arg Ser Leu Leu 
1               5                   10                  15      


Ala Phe Ile Phe Phe Phe Ser Leu Ser Ser Ser Cys Leu Tyr Phe Ile 
            20                  25                  30          


Tyr Val Ala Pro Gly Ile Ala Asn Thr Tyr Leu Phe Met Val Gln Ala 
        35                  40                  45              


Arg Gly Ile Met Leu Arg Glu Asn Val Lys Thr Ile Gly His Met Ile 
    50                  55                  60                  


Arg Leu Tyr Thr Asn Lys Asn Ser Thr Leu Asn Gly Thr Asp Tyr Pro 
65                  70                  75                  80  


Glu Gly Asn Asn Ser Ser Asp Tyr Leu Val Gln Thr Thr Thr Tyr Leu 
                85                  90                  95      


Pro Glu Asn Phe Thr Tyr Ser Pro Tyr Leu Pro Cys Pro Glu Lys Leu 
            100                 105                 110         


Pro Tyr Met Arg Gly Phe Leu Asn Val Asn Val Ser Glu Val Ser Phe 
        115                 120                 125             


Asp Glu Ile His Gln Leu Phe Ser Lys Asp Leu Asp Ile Glu Pro Gly 
    130                 135                 140                 


Gly His Trp Arg Pro Lys Asp Cys Lys Pro Arg Trp Lys Val Ala Val 
145                 150                 155                 160 


Leu Ile Pro Phe Arg Asn Arg His Glu His Leu Pro Ile Phe Phe Leu 
                165                 170                 175     


His Leu Ile Pro Met Leu Gln Lys Gln Arg Leu Glu Phe Ala Phe Tyr 
            180                 185                 190         


Val Ile Glu Gln Thr Gly Thr Gln Pro Phe Asn Arg Ala Met Leu Phe 
        195                 200                 205             


Asn Val Gly Phe Lys Glu Ala Met Lys Asp Ser Val Trp Asp Cys Val 
    210                 215                 220                 


Ile Phe His Asp Val Asp His Leu Pro Glu Asn Asp Arg Asn Tyr Tyr 
225                 230                 235                 240 


Gly Cys Gly Glu Met Pro Arg His Phe Ala Ala Lys Leu Asp Lys Tyr 
                245                 250                 255     


Met Tyr Ile Leu Pro Tyr Lys Glu Phe Phe Gly Gly Val Ser Gly Leu 
            260                 265                 270         


Thr Val Glu Gln Phe Arg Lys Ile Asn Gly Phe Pro Asn Ala Phe Trp 
        275                 280                 285             


Gly Trp Gly Gly Glu Asp Asp Asp Leu Trp Asn Arg Val His Tyr Ala 
    290                 295                 300                 


Gly Tyr Asn Val Thr Arg Pro Glu Gly Asp Leu Gly Lys Tyr Lys Ser 
305                 310                 315                 320 


Ile Pro His His His Arg Gly Glu Val Gln Phe Leu Gly Arg Tyr Lys 
                325                 330                 335     


Leu Leu Arg Tyr Ser Lys Glu Arg Gln Tyr Ile Asp Gly Leu Asn Asn 
            340                 345                 350         


Leu Ile Tyr Arg Pro Lys Ile Leu Val Asp Arg Leu Tyr Thr Asn Ile 
        355                 360                 365             


Ser Val Asn Leu Met Pro Glu Leu Ala Pro Ile Glu Asp Tyr 
    370                 375                 380         


<210>  3122
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  3122

Met Arg Ala Arg Arg Gly Leu Leu Arg Leu Pro Arg Arg Ser Leu Leu 
1               5                   10                  15      


Ala Ala Leu Phe Phe Phe Ser Leu Ser Ser Ser Leu Leu Tyr Phe Val 
            20                  25                  30          


Tyr Val Ala Pro Gly Ile Val Asn Thr Tyr Leu Phe Met Met Gln Ala 
        35                  40                  45              


Gln Gly Ile Leu Ile Arg Asp Asn Val Arg Thr Ile Gly Ala Gln Val 
    50                  55                  60                  


Tyr Glu Gln Val Leu Arg Ser Ala Tyr Ala Lys Arg Asn Ser Ser Val 
65                  70                  75                  80  


Asn Asp Ser Asp Tyr Pro Leu Asp Leu Asn His Ser Glu Thr Phe Leu 
                85                  90                  95      


Gln Thr Thr Thr Phe Leu Pro Glu Asp Phe Thr Tyr Phe Ala Asn His 
            100                 105                 110         


Thr Cys Pro Glu Arg Leu Pro Ser Met Lys Gly Pro Ile Asp Ile Asn 
        115                 120                 125             


Met Ser Glu Ile Gly Met Asp Tyr Ile His Glu Leu Phe Ser Lys Asp 
    130                 135                 140                 


Pro Thr Ile Lys Leu Gly Gly His Trp Lys Pro Ser Asp Cys Met Pro 
145                 150                 155                 160 


Arg Trp Lys Val Ala Ile Leu Ile Pro Phe Arg Asn Arg His Glu His 
                165                 170                 175     


Leu Pro Val Leu Phe Arg His Leu Leu Pro Met Leu Gln Arg Gln Arg 
            180                 185                 190         


Leu Gln Phe Ala Phe Tyr Val Val Glu Gln Val Gly Thr Gln Pro Phe 
        195                 200                 205             


Asn Arg Ala Met Leu Phe Asn Val Gly Phe Gln Glu Ala Met Lys Asp 
    210                 215                 220                 


Leu Asp Trp Asp Cys Leu Ile Phe His Asp Val Asp His Ile Pro Glu 
225                 230                 235                 240 


Ser Asp Arg Asn Tyr Tyr Gly Cys Gly Gln Met Pro Arg His Phe Ala 
                245                 250                 255     


Thr Lys Leu Asp Lys Tyr Met Tyr Leu Leu Pro Tyr Thr Glu Phe Phe 
            260                 265                 270         


Gly Gly Val Ser Gly Leu Thr Val Glu Gln Phe Arg Lys Ile Asn Gly 
        275                 280                 285             


Phe Pro Asn Ala Phe Trp Gly Trp Gly Gly Glu Asp Asp Asp Leu Trp 
    290                 295                 300                 


Asn Arg Val Gln Asn Ala Gly Tyr Ser Val Ser Arg Pro Glu Gly Asp 
305                 310                 315                 320 


Thr Gly Lys Tyr Lys Ser Ile Pro His His His Arg Gly Glu Val Gln 
                325                 330                 335     


Phe Leu Gly Arg Tyr Ala Leu Leu Arg Lys Ser Lys Glu Arg Gln Gly 
            340                 345                 350         


Leu Asp Gly Leu Asn Asn Leu Asn Tyr Phe Ala Asn Ile Thr Tyr Asp 
        355                 360                 365             


Ala Leu Tyr Lys Asn Ile Thr Val Asn Leu Thr Pro Glu Leu Ala Gln 
    370                 375                 380                 


Val Asn Glu Tyr 
385             


<210>  3123
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  3123

Met Ser Ala Asn Ala Thr Leu Lys Pro Leu Cys Pro Ile Leu Glu Gln 
1               5                   10                  15      


Met Ser Arg Leu Gln Ser His Ser Asn Thr Ser Ile Arg Tyr Ile Asp 
            20                  25                  30          


His Ala Ala Val Leu Leu His Gly Leu Ala Ser Leu Leu Gly Leu Val 
        35                  40                  45              


Glu Asn Gly Val Ile Leu Phe Val Val Gly Cys Arg Met Arg Gln Thr 
    50                  55                  60                  


Val Val Thr Thr Trp Val Leu His Leu Ala Leu Ser Asp Leu Leu Ala 
65                  70                  75                  80  


Ser Ala Ser Leu Pro Phe Phe Thr Tyr Phe Leu Ala Val Gly His Ser 
                85                  90                  95      


Trp Glu Leu Gly Thr Thr Phe Cys Lys Leu His Ser Ser Ile Phe Phe 
            100                 105                 110         


Leu Asn Met Phe Ala Ser Gly Phe Leu Leu Ser Ala Ile Ser Leu Asp 
        115                 120                 125             


Arg Cys Leu Gln Val Val Arg Pro Val Trp Ala Gln Asn His Arg Thr 
    130                 135                 140                 


Val Ala Ala Ala His Lys Val Cys Leu Val Leu Trp Ala Leu Ala Val 
145                 150                 155                 160 


Leu Asn Thr Val Pro Tyr Phe Val Phe Arg Asp Thr Ile Ser Arg Leu 
                165                 170                 175     


Asp Gly Arg Ile Met Cys Tyr Tyr Asn Val Leu Leu Leu Asn Pro Gly 
            180                 185                 190         


Pro Asp Arg Asp Ala Thr Cys Asn Ser Arg Gln Val Ala Leu Ala Val 
        195                 200                 205             


Ser Lys Phe Leu Leu Ala Phe Leu Val Pro Leu Ala Ile Ile Ala Ser 
    210                 215                 220                 


Ser His Ala Ala Val Ser Leu Arg Leu Gln His Arg Gly Arg Arg Arg 
225                 230                 235                 240 


Pro Gly Arg Phe Val Arg Leu Val Ala Ala Val Val Ala Ala Phe Ala 
                245                 250                 255     


Leu Cys Trp Gly Pro Tyr His Val Phe Ser Leu Leu Glu Ala Arg Ala 
            260                 265                 270         


His Ala Asn Pro Gly Leu Arg Pro Leu Val Trp Arg Gly Leu Pro Phe 
        275                 280                 285             


Val Thr Ser Leu Ala Phe Phe Asn Ser Val Ala Asn Pro Val Leu Tyr 
    290                 295                 300                 


Val Leu Thr Cys Pro Asp Met Leu Arg Lys Leu Arg Arg Ser Leu Arg 
305                 310                 315                 320 


Thr Val Leu Glu Ser Val Leu Val Asp Asp Ser Glu Leu Gly Gly Ala 
                325                 330                 335     


Gly Ser Ser Arg Arg Arg Arg Thr Ser Ser Thr Ala Arg Ser Ala Ser 
            340                 345                 350         


Pro Leu Ala Leu Cys Ser Arg Pro Glu Glu Pro Arg Gly Pro Ala Arg 
        355                 360                 365             


Leu Leu Gly Trp Leu Leu Gly Ser Cys Ala Ala Ser Pro Gln Thr Gly 
    370                 375                 380                 


Pro Leu Asn Arg Ala Leu Ser Ser Thr Ser Ser 
385                 390                 395 


<210>  3124
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  3124

Met Ser Thr Gly Pro Thr Ala Ala Thr Gly Ser Asn Arg Arg Leu Gln 
1               5                   10                  15      


Gln Thr Gln Asn Gln Val Asp Glu Val Val Asp Ile Met Arg Val Asn 
            20                  25                  30          


Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp 
        35                  40                  45              


Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser Ala 
    50                  55                  60                  


Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Cys Lys Met Trp Ala 
65                  70                  75                  80  


Ile Gly Ile Thr Val Leu Val Ile Phe Ile Ile Ile Ile Ile Val Trp 
                85                  90                  95      


Val Val Ser Ser 
            100 


<210>  3125
<211>  1049
<212>  PRT
<213>  Homo sapiens

<400>  3125

Met Pro Ala Gly Gly Arg Ala Gly Ser Leu Lys Asp Pro Asp Val Ala 
1               5                   10                  15      


Glu Leu Phe Phe Lys Asp Asp Pro Glu Lys Leu Phe Ser Asp Leu Arg 
            20                  25                  30          


Glu Ile Gly His Gly Ser Phe Gly Ala Val Tyr Phe Ala Arg Asp Val 
        35                  40                  45              


Arg Asn Ser Glu Val Val Ala Ile Lys Lys Met Ser Tyr Ser Gly Lys 
    50                  55                  60                  


Gln Ser Asn Glu Lys Trp Gln Asp Ile Ile Lys Glu Val Arg Phe Leu 
65                  70                  75                  80  


Gln Lys Leu Arg His Pro Asn Thr Ile Gln Tyr Arg Gly Cys Tyr Leu 
                85                  90                  95      


Arg Glu His Thr Ala Trp Leu Val Met Glu Tyr Cys Leu Gly Ser Ala 
            100                 105                 110         


Ser Asp Leu Leu Glu Val His Lys Lys Pro Leu Gln Glu Val Glu Ile 
        115                 120                 125             


Ala Ala Val Thr His Gly Ala Leu Gln Gly Leu Ala Tyr Leu His Ser 
    130                 135                 140                 


His Asn Met Ile His Arg Asp Val Lys Ala Gly Asn Ile Leu Leu Ser 
145                 150                 155                 160 


Glu Pro Gly Leu Val Lys Leu Gly Asp Phe Gly Ser Ala Ser Ile Met 
                165                 170                 175     


Ala Pro Ala Asn Ser Phe Val Gly Thr Pro Tyr Trp Met Ala Pro Glu 
            180                 185                 190         


Val Ile Leu Ala Met Asp Glu Gly Gln Tyr Asp Gly Lys Val Asp Val 
        195                 200                 205             


Trp Ser Leu Gly Ile Thr Cys Ile Glu Leu Ala Glu Arg Lys Pro Pro 
    210                 215                 220                 


Leu Phe Asn Met Asn Ala Met Ser Ala Leu Tyr His Ile Ala Gln Asn 
225                 230                 235                 240 


Glu Ser Pro Val Leu Gln Ser Gly His Trp Ser Glu Tyr Phe Arg Asn 
                245                 250                 255     


Phe Val Asp Ser Cys Leu Gln Lys Ile Pro Gln Asp Arg Pro Thr Ser 
            260                 265                 270         


Glu Val Leu Leu Lys His Arg Phe Val Leu Arg Glu Arg Pro Pro Thr 
        275                 280                 285             


Val Ile Met Asp Leu Ile Gln Arg Thr Lys Asp Ala Val Arg Glu Leu 
    290                 295                 300                 


Asp Asn Leu Gln Tyr Arg Lys Met Lys Lys Ile Leu Phe Gln Glu Ala 
305                 310                 315                 320 


Pro Asn Gly Pro Gly Ala Glu Ala Pro Glu Glu Glu Glu Glu Ala Glu 
                325                 330                 335     


Pro Tyr Met His Arg Ala Gly Thr Leu Thr Ser Leu Glu Ser Ser His 
            340                 345                 350         


Ser Val Pro Ser Met Ser Ile Ser Ala Ser Ser Gln Ser Ser Ser Val 
        355                 360                 365             


Asn Ser Leu Ala Asp Ala Ser Asp Asn Glu Glu Glu Glu Glu Glu Glu 
    370                 375                 380                 


Glu Glu Glu Glu Glu Glu Glu Glu Gly Pro Glu Ala Arg Glu Met Ala 
385                 390                 395                 400 


Met Met Gln Glu Gly Glu His Thr Val Thr Ser His Ser Ser Ile Ile 
                405                 410                 415     


His Arg Leu Pro Gly Ser Asp Asn Leu Tyr Asp Asp Pro Tyr Gln Pro 
            420                 425                 430         


Glu Ile Thr Pro Ser Pro Leu Gln Pro Pro Ala Ala Pro Ala Pro Thr 
        435                 440                 445             


Ser Thr Thr Ser Ser Ala Arg Arg Arg Ala Tyr Cys Arg Asn Arg Asp 
    450                 455                 460                 


His Phe Ala Thr Ile Arg Thr Ala Ser Leu Val Ser Arg Gln Ile Gln 
465                 470                 475                 480 


Glu His Glu Gln Asp Ser Ala Leu Arg Glu Gln Leu Ser Gly Tyr Lys 
                485                 490                 495     


Arg Met Arg Arg Gln His Gln Lys Gln Leu Leu Ala Leu Glu Ser Arg 
            500                 505                 510         


Leu Arg Gly Glu Arg Glu Glu His Ser Ala Arg Leu Gln Arg Glu Leu 
        515                 520                 525             


Glu Ala Gln Arg Ala Gly Phe Gly Ala Glu Ala Glu Lys Leu Ala Arg 
    530                 535                 540                 


Arg His Gln Ala Ile Gly Glu Lys Glu Ala Arg Ala Ala Gln Ala Glu 
545                 550                 555                 560 


Glu Arg Lys Phe Gln Gln His Ile Leu Gly Gln Gln Lys Lys Glu Leu 
                565                 570                 575     


Ala Ala Leu Leu Glu Ala Gln Lys Arg Thr Tyr Lys Leu Arg Lys Glu 
            580                 585                 590         


Gln Leu Lys Glu Glu Leu Gln Glu Asn Pro Ser Thr Pro Lys Arg Glu 
        595                 600                 605             


Lys Ala Glu Trp Leu Leu Arg Gln Lys Glu Gln Leu Gln Gln Cys Gln 
    610                 615                 620                 


Ala Glu Glu Glu Ala Gly Leu Leu Arg Arg Gln Arg Gln Tyr Phe Glu 
625                 630                 635                 640 


Leu Gln Cys Arg Gln Tyr Lys Arg Lys Met Leu Leu Ala Arg His Ser 
                645                 650                 655     


Leu Asp Gln Asp Leu Leu Arg Glu Asp Leu Asn Lys Lys Gln Thr Gln 
            660                 665                 670         


Lys Asp Leu Glu Cys Ala Leu Leu Leu Arg Gln His Glu Ala Thr Arg 
        675                 680                 685             


Glu Leu Glu Leu Arg Gln Leu Gln Ala Val Gln Arg Thr Arg Ala Glu 
    690                 695                 700                 


Leu Thr Arg Leu Gln His Gln Thr Glu Leu Gly Asn Gln Leu Glu Tyr 
705                 710                 715                 720 


Asn Lys Arg Arg Glu Gln Glu Leu Arg Gln Lys His Ala Ala Gln Val 
                725                 730                 735     


Arg Gln Gln Pro Lys Ser Leu Lys Ser Lys Glu Leu Gln Ile Lys Lys 
            740                 745                 750         


Gln Phe Gln Glu Thr Cys Lys Ile Gln Thr Arg Gln Tyr Lys Ala Leu 
        755                 760                 765             


Arg Ala His Leu Leu Glu Thr Thr Pro Lys Ala Gln His Lys Ser Leu 
    770                 775                 780                 


Leu Lys Arg Leu Lys Glu Glu Gln Thr Arg Lys Leu Ala Ile Leu Ala 
785                 790                 795                 800 


Glu Gln Tyr Asp Gln Ser Ile Ser Glu Met Leu Ser Ser Gln Ala Leu 
                805                 810                 815     


Arg Leu Asp Glu Thr Gln Glu Ala Glu Phe Gln Ala Leu Arg Gln Gln 
            820                 825                 830         


Leu Gln Gln Glu Leu Glu Leu Leu Asn Ala Tyr Gln Ser Lys Ile Lys 
        835                 840                 845             


Ile Arg Thr Glu Ser Gln His Glu Arg Glu Leu Arg Glu Leu Glu Gln 
    850                 855                 860                 


Arg Val Ala Leu Arg Arg Ala Leu Leu Glu Gln Arg Val Glu Glu Glu 
865                 870                 875                 880 


Leu Leu Ala Leu Gln Thr Gly Arg Ser Glu Arg Ile Arg Ser Leu Leu 
                885                 890                 895     


Glu Arg Gln Ala Arg Glu Ile Glu Ala Phe Asp Ala Glu Ser Met Arg 
            900                 905                 910         


Leu Gly Phe Ser Ser Met Ala Leu Gly Gly Ile Pro Ala Glu Ala Ala 
        915                 920                 925             


Ala Gln Gly Tyr Pro Ala Pro Pro Pro Ala Pro Ala Trp Pro Ser Arg 
    930                 935                 940                 


Pro Val Pro Arg Ser Gly Ala His Trp Ser His Gly Pro Pro Pro Pro 
945                 950                 955                 960 


Gly Met Pro Pro Pro Ala Trp Arg Gln Pro Ser Leu Leu Ala Pro Pro 
                965                 970                 975     


Gly Pro Pro Asn Trp Leu Gly Pro Pro Thr Gln Ser Gly Thr Pro Arg 
            980                 985                 990         


Gly Gly Ala Leu Leu Leu Leu Arg  Asn Ser Pro Gln Pro  Leu Arg Arg 
        995                 1000                 1005             


Ala Ala  Ser Gly Gly Ser Gly  Ser Glu Asn Val Gly  Pro Pro Ala 
    1010                 1015                 1020             


Ala Ala  Val Pro Gly Pro Leu  Ser Arg Ser Thr Ser  Val Ala Ser 
    1025                 1030                 1035             


His Ile  Leu Asn Gly Ser Ser  His Phe Tyr Ser 
    1040                 1045                 


<210>  3126
<211>  873
<212>  PRT
<213>  Homo sapiens

<400>  3126

Met Ser Phe Ile Met Lys Leu His Arg His Phe Gln Arg Thr Val Ile 
1               5                   10                  15      


Leu Leu Ala Thr Phe Cys Met Val Ser Ile Ile Ile Ser Ala Tyr Tyr 
            20                  25                  30          


Leu Tyr Ser Gly Tyr Lys Gln Glu Asn Glu Leu Ser Glu Thr Ala Ser 
        35                  40                  45              


Glu Val Asp Cys Gly Asp Leu Gln His Leu Pro Tyr Gln Leu Met Glu 
    50                  55                  60                  


Val Lys Ala Met Lys Leu Phe Asp Ala Ser Arg Thr Asp Pro Thr Val 
65                  70                  75                  80  


Leu Val Phe Val Glu Ser Gln Tyr Ser Ser Leu Gly Gln Asp Ile Ile 
                85                  90                  95      


Met Ile Leu Glu Ser Ser Arg Phe Gln Tyr His Ile Glu Ile Ala Pro 
            100                 105                 110         


Gly Lys Gly Asp Leu Pro Val Leu Ile Asp Lys Met Lys Gly Lys Tyr 
        115                 120                 125             


Ile Leu Ile Ile Tyr Glu Asn Ile Leu Lys Tyr Ile Asn Met Asp Ser 
    130                 135                 140                 


Trp Asn Arg Ser Leu Leu Asp Lys Tyr Cys Val Glu Tyr Gly Val Gly 
145                 150                 155                 160 


Val Ile Gly Phe His Lys Thr Ser Glu Lys Ser Val Gln Ser Phe Gln 
                165                 170                 175     


Leu Lys Gly Phe Pro Phe Ser Ile Tyr Gly Asn Leu Ala Val Lys Asp 
            180                 185                 190         


Cys Cys Ile Asn Pro His Ser Pro Leu Ile Arg Val Thr Lys Ser Ser 
        195                 200                 205             


Lys Leu Glu Lys Gly Ser Leu Pro Gly Thr Asp Trp Thr Val Phe Gln 
    210                 215                 220                 


Ile Asn His Ser Ala Tyr Gln Pro Val Ile Phe Ala Lys Val Lys Thr 
225                 230                 235                 240 


Pro Glu Asn Leu Ser Pro Ser Ile Ser Lys Gly Ala Phe Tyr Ala Thr 
                245                 250                 255     


Ile Ile His Asp Leu Gly Leu His Asp Gly Ile Gln Arg Val Leu Phe 
            260                 265                 270         


Gly Asn Asn Leu Asn Phe Trp Leu His Lys Leu Ile Phe Ile Asp Ala 
        275                 280                 285             


Ile Ser Phe Leu Ser Gly Lys Arg Leu Thr Leu Ser Leu Asp Arg Tyr 
    290                 295                 300                 


Ile Leu Val Asp Ile Asp Asp Ile Phe Val Gly Lys Glu Gly Thr Arg 
305                 310                 315                 320 


Met Asn Thr Asn Asp Val Lys Ala Leu Leu Asp Thr Gln Asn Leu Leu 
                325                 330                 335     


Arg Ala Gln Ile Thr Asn Phe Thr Phe Asn Leu Gly Phe Ser Gly Lys 
            340                 345                 350         


Phe Tyr His Thr Gly Thr Glu Glu Glu Asp Glu Gly Asp Asp Cys Leu 
        355                 360                 365             


Leu Gly Ser Val Asp Glu Phe Trp Trp Phe Pro His Met Trp Ser His 
    370                 375                 380                 


Met Gln Pro His Leu Phe His Asn Glu Ser Ser Leu Val Glu Gln Met 
385                 390                 395                 400 


Ile Leu Asn Lys Lys Phe Ala Leu Glu His Gly Ile Pro Thr Asp Met 
                405                 410                 415     


Gly Tyr Ala Val Ala Pro His His Ser Gly Val Tyr Pro Val His Val 
            420                 425                 430         


Gln Leu Tyr Glu Ala Trp Lys Lys Val Trp Asn Ile Lys Ile Thr Ser 
        435                 440                 445             


Thr Glu Glu Tyr Pro His Leu Lys Pro Ala Arg Tyr Arg Arg Gly Phe 
    450                 455                 460                 


Ile His Lys Asn Ile Met Val Leu Pro Arg Gln Thr Cys Gly Leu Phe 
465                 470                 475                 480 


Thr His Thr Ile Phe Tyr Lys Glu Tyr Pro Gly Gly Pro Lys Glu Leu 
                485                 490                 495     


Asp Lys Ser Ile Gln Gly Gly Glu Leu Phe Phe Thr Val Val Leu Asn 
            500                 505                 510         


Pro Ile Ser Ile Phe Met Thr His Leu Ser Asn Tyr Gly Asn Asp Arg 
        515                 520                 525             


Leu Gly Leu Tyr Thr Phe Val Asn Leu Ala Asn Phe Val Lys Ser Trp 
    530                 535                 540                 


Thr Asn Leu Arg Leu Gln Thr Leu Pro Pro Val Gln Leu Ala His Lys 
545                 550                 555                 560 


Tyr Phe Glu Leu Phe Pro Asp Gln Lys Asp Pro Leu Trp Gln Asn Pro 
                565                 570                 575     


Cys Asp Asp Lys Arg His Arg Asp Ile Trp Ser Lys Glu Lys Thr Cys 
            580                 585                 590         


Asp Arg Leu Pro Lys Phe Leu Val Ile Gly Pro Gln Lys Thr Gly Thr 
        595                 600                 605             


Thr Ala Leu Tyr Leu Phe Leu Val Met His Pro Ser Ile Leu Ser Asn 
    610                 615                 620                 


Ser Pro Ser Pro Lys Thr Phe Glu Glu Val Gln Phe Phe Asn Arg Asn 
625                 630                 635                 640 


Asn Tyr His Arg Gly Ile Asp Trp Tyr Met Asp Phe Phe Pro Val Pro 
                645                 650                 655     


Ser Asn Val Thr Thr Asp Phe Leu Phe Glu Lys Ser Ala Asn Tyr Phe 
            660                 665                 670         


His Ser Glu Glu Ala Pro Lys Arg Ala Ala Ser Leu Val Pro Lys Ala 
        675                 680                 685             


Lys Ile Ile Thr Ile Leu Ile Asp Pro Ser Asp Arg Ala Tyr Ser Trp 
    690                 695                 700                 


Tyr Gln His Gln Arg Ser His Glu Asp Pro Ala Ala Leu Lys Phe Ser 
705                 710                 715                 720 


Phe Tyr Glu Val Ile Ser Ala Gly Pro Arg Ala Pro Ser Glu Leu Arg 
                725                 730                 735     


Ala Leu Gln Lys Arg Cys Leu Val Pro Gly Trp Tyr Ala Ser His Ile 
            740                 745                 750         


Glu Arg Trp Leu Val Tyr Phe Pro Pro Phe Gln Leu Leu Ile Ile Asp 
        755                 760                 765             


Gly Gln Gln Leu Arg Thr Asp Pro Ala Thr Val Met Asp Glu Val Gln 
    770                 775                 780                 


Lys Phe Leu Gly Val Leu Pro His Tyr Asn Tyr Ser Glu Ala Leu Thr 
785                 790                 795                 800 


Phe Asp Ser His Lys Gly Phe Trp Cys Gln Leu Leu Glu Glu Gly Lys 
                805                 810                 815     


Thr Lys Cys Leu Gly Lys Ser Lys Gly Arg Lys Tyr Pro Pro Met Asp 
            820                 825                 830         


Ser Asp Ser Arg Thr Phe Leu Ser Ser Tyr Tyr Arg Asp His Asn Val 
        835                 840                 845             


Glu Leu Ser Lys Leu Leu His Lys Leu Gly Gln Pro Leu Pro Ser Trp 
    850                 855                 860                 


Leu Arg Gln Glu Leu Gln Lys Val Arg 
865                 870             


<210>  3127
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  3127

Met Ala Phe Asn Asp Leu Leu Gln Gln Val Gly Gly Val Gly Arg Phe 
1               5                   10                  15      


Gln Gln Ile Gln Val Thr Leu Val Val Leu Pro Leu Leu Leu Met Ala 
            20                  25                  30          


Ser His Asn Thr Leu Gln Asn Phe Thr Ala Ala Ile Pro Thr His His 
        35                  40                  45              


Cys Arg Pro Pro Ala Asp Ala Asn Leu Ser Lys Asn Gly Gly Leu Glu 
    50                  55                  60                  


Val Trp Leu Pro Arg Asp Arg Gln Gly Gln Pro Glu Ser Cys Leu Arg 
65                  70                  75                  80  


Phe Thr Ser Pro Gln Trp Gly Leu Pro Phe Leu Asn Gly Thr Glu Ala 
                85                  90                  95      


Asn Gly Thr Gly Ala Thr Glu Pro Cys Thr Asp Gly Trp Ile Tyr Asp 
            100                 105                 110         


Asn Ser Thr Phe Pro Ser Thr Ile Val Thr Glu Trp Asp Leu Val Cys 
        115                 120                 125             


Ser His Arg Ala Leu Arg Gln Leu Ala Gln Ser Leu Tyr Met Val Gly 
    130                 135                 140                 


Val Leu Leu Gly Ala Met Val Phe Gly Tyr Leu Ala Asp Arg Leu Gly 
145                 150                 155                 160 


Arg Arg Lys Val Leu Ile Leu Asn Tyr Leu Gln Thr Ala Val Ser Gly 
                165                 170                 175     


Thr Cys Ala Ala Phe Ala Pro Asn Phe Pro Ile Tyr Cys Ala Phe Arg 
            180                 185                 190         


Leu Leu Ser Gly Met Ala Leu Ala Gly Ile Ser Leu Asn Cys Met Thr 
        195                 200                 205             


Leu Asn Val Glu Trp Met Pro Ile His Thr Arg Ala Cys Val Gly Thr 
    210                 215                 220                 


Leu Ile Gly Tyr Val Tyr Ser Leu Gly Gln Phe Leu Leu Ala Gly Val 
225                 230                 235                 240 


Ala Tyr Ala Val Pro His Trp Arg His Leu Gln Leu Leu Val Ser Ala 
                245                 250                 255     


Pro Phe Phe Ala Phe Phe Ile Tyr Ser Trp Phe Phe Ile Glu Ser Ala 
            260                 265                 270         


Arg Trp His Ser Ser Ser Gly Arg Leu Asp Leu Thr Leu Arg Ala Leu 
        275                 280                 285             


Gln Arg Val Ala Arg Ile Asn Gly Lys Arg Glu Glu Gly Ala Lys Leu 
    290                 295                 300                 


Ser Met Glu Val Leu Arg Ala Ser Leu Gln Lys Glu Leu Thr Met Gly 
305                 310                 315                 320 


Lys Gly Gln Ala Ser Ala Met Glu Leu Leu Arg Cys Pro Thr Leu Arg 
                325                 330                 335     


His Leu Phe Leu Cys Leu Ser Met Leu Trp Phe Ala Thr Ser Phe Ala 
            340                 345                 350         


Tyr Tyr Gly Leu Val Met Asp Leu Gln Gly Phe Gly Val Ser Ile Tyr 
        355                 360                 365             


Leu Ile Gln Val Ile Phe Gly Ala Val Asp Leu Pro Ala Lys Leu Val 
    370                 375                 380                 


Gly Phe Leu Val Ile Asn Ser Leu Gly Arg Arg Pro Ala Gln Met Ala 
385                 390                 395                 400 


Ala Leu Leu Leu Ala Gly Ile Cys Ile Leu Leu Asn Gly Val Ile Pro 
                405                 410                 415     


Gln Asp Gln Ser Ile Val Arg Thr Ser Leu Ala Val Leu Gly Lys Gly 
            420                 425                 430         


Cys Leu Ala Ala Ser Phe Asn Cys Ile Phe Leu Tyr Thr Gly Glu Leu 
        435                 440                 445             


Tyr Pro Thr Met Ile Arg Gln Thr Gly Met Gly Met Gly Ser Thr Met 
    450                 455                 460                 


Ala Arg Val Gly Ser Ile Val Ser Pro Leu Val Ser Met Thr Ala Glu 
465                 470                 475                 480 


Leu Tyr Pro Ser Met Pro Leu Phe Ile Tyr Gly Ala Val Pro Val Ala 
                485                 490                 495     


Ala Ser Ala Val Thr Val Leu Leu Pro Glu Thr Leu Gly Gln Pro Leu 
            500                 505                 510         


Pro Asp Thr Val Gln Asp Leu Glu Ser Arg Trp Ala Pro Thr Gln Lys 
        515                 520                 525             


Glu Ala Gly Ile Tyr Pro Arg Lys Gly Lys Gln Thr Arg Gln Gln Gln 
    530                 535                 540                 


Glu His Gln Lys Tyr Met Val Pro Leu Gln Ala Ser Ala Gln Glu Lys 
545                 550                 555                 560 


Asn Gly Leu 
            


<210>  3128
<211>  1012
<212>  PRT
<213>  Homo sapiens

<400>  3128

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser Leu Leu Ala Phe Ile Ala Phe Leu Phe Phe Ala 
            980                 985                 990         


Ser Ile Ile Ser Leu Ser Leu Ile  Phe Tyr Tyr Ser Lys  Lys Gly Arg 
        995                 1000                 1005             


Arg Ser  Tyr Lys 
    1010         


<210>  3129
<211>  1061
<212>  PRT
<213>  Homo sapiens

<400>  3129

Met Leu Gly Ser Asp Asp Phe Phe Tyr Val Gly Gly Ser Pro Ser Thr 
1               5                   10                  15      


Ala Asp Leu Pro Gly Ser Pro Val Ser Asn Asn Phe Met Gly Cys Leu 
            20                  25                  30          


Lys Glu Val Val Tyr Lys Asn Asn Asp Ile Arg Leu Glu Leu Ser Arg 
        35                  40                  45              


Leu Ala Arg Ile Ala Asp Thr Lys Met Lys Ile Tyr Gly Glu Val Val 
    50                  55                  60                  


Phe Lys Cys Glu Asn Val Ala Thr Leu Asp Pro Ile Asn Phe Glu Thr 
65                  70                  75                  80  


Pro Glu Ala Tyr Ile Ser Leu Pro Lys Trp Asn Thr Lys Arg Met Gly 
                85                  90                  95      


Ser Ile Ser Phe Asp Phe Arg Thr Thr Glu Pro Asn Gly Leu Ile Leu 
            100                 105                 110         


Phe Thr His Gly Lys Pro Gln Glu Arg Lys Asp Ala Arg Ser Gln Lys 
        115                 120                 125             


Asn Thr Lys Val Asp Phe Phe Ala Val Glu Leu Leu Asp Gly Asn Leu 
    130                 135                 140                 


Tyr Leu Leu Leu Asp Met Gly Ser Gly Thr Ile Lys Val Lys Ala Thr 
145                 150                 155                 160 


Gln Lys Lys Ala Asn Asp Gly Glu Trp Tyr His Val Asp Ile Gln Arg 
                165                 170                 175     


Asp Gly Arg Ser Gly Thr Ile Ser Val Asn Ser Arg Arg Thr Pro Phe 
            180                 185                 190         


Thr Ala Ser Gly Glu Ser Glu Ile Leu Asp Leu Glu Gly Asp Met Tyr 
        195                 200                 205             


Leu Gly Gly Leu Pro Glu Asn Arg Ala Gly Leu Ile Leu Pro Thr Glu 
    210                 215                 220                 


Leu Trp Thr Ala Met Leu Asn Tyr Gly Tyr Val Gly Cys Ile Arg Asp 
225                 230                 235                 240 


Leu Phe Ile Asp Gly Arg Ser Lys Asn Ile Arg Gln Leu Ala Glu Met 
                245                 250                 255     


Gln Asn Ala Ala Gly Val Lys Ser Ser Cys Ser Arg Met Ser Ala Lys 
            260                 265                 270         


Gln Cys Asp Ser Tyr Pro Cys Lys Asn Asn Ala Val Cys Lys Asp Gly 
        275                 280                 285             


Trp Asn Arg Phe Ile Cys Asp Cys Thr Gly Thr Gly Tyr Trp Gly Arg 
    290                 295                 300                 


Thr Cys Glu Arg Glu Ala Ser Ile Leu Ser Tyr Asp Gly Ser Met Tyr 
305                 310                 315                 320 


Met Lys Ile Ile Met Pro Met Val Met His Thr Glu Ala Glu Asp Val 
                325                 330                 335     


Ser Phe Arg Phe Met Ser Gln Arg Ala Tyr Gly Leu Leu Val Ala Thr 
            340                 345                 350         


Thr Ser Arg Asp Ser Ala Asp Thr Leu Arg Leu Glu Leu Asp Gly Gly 
        355                 360                 365             


Arg Val Lys Leu Met Val Asn Leu Asp Cys Ile Arg Ile Asn Cys Asn 
    370                 375                 380                 


Ser Ser Lys Gly Pro Glu Thr Leu Tyr Ala Gly Gln Lys Leu Asn Asp 
385                 390                 395                 400 


Asn Glu Trp His Thr Val Arg Val Val Arg Arg Gly Lys Ser Leu Lys 
                405                 410                 415     


Leu Thr Val Asp Asp Asp Val Ala Glu Gly Thr Met Val Gly Asp His 
            420                 425                 430         


Thr Arg Leu Glu Phe His Asn Ile Glu Thr Gly Ile Met Thr Glu Lys 
        435                 440                 445             


Arg Tyr Ile Ser Val Val Pro Ser Ser Phe Ile Gly His Leu Gln Ser 
    450                 455                 460                 


Leu Met Phe Asn Gly Leu Leu Tyr Ile Asp Leu Cys Lys Asn Gly Asp 
465                 470                 475                 480 


Ile Asp Tyr Cys Glu Leu Lys Ala Arg Phe Gly Leu Arg Asn Ile Ile 
                485                 490                 495     


Ala Asp Pro Val Thr Phe Lys Thr Lys Ser Ser Tyr Leu Ser Leu Ala 
            500                 505                 510         


Thr Leu Gln Ala Tyr Thr Ser Met His Leu Phe Phe Gln Phe Lys Thr 
        515                 520                 525             


Thr Ser Pro Asp Gly Phe Ile Leu Phe Asn Ser Gly Asp Gly Asn Asp 
    530                 535                 540                 


Phe Ile Ala Val Glu Leu Val Lys Gly Tyr Ile His Tyr Val Phe Asp 
545                 550                 555                 560 


Leu Gly Asn Gly Pro Asn Val Ile Lys Gly Asn Ser Asp Arg Pro Leu 
                565                 570                 575     


Asn Asp Asn Gln Trp His Asn Val Val Ile Thr Arg Asp Asn Ser Asn 
            580                 585                 590         


Thr His Ser Leu Lys Val Asp Thr Lys Val Val Thr Gln Val Ile Asn 
        595                 600                 605             


Gly Ala Lys Asn Leu Asp Leu Lys Gly Asp Leu Tyr Met Ala Gly Leu 
    610                 615                 620                 


Ala Gln Gly Met Tyr Ser Asn Leu Pro Lys Leu Val Ala Ser Arg Asp 
625                 630                 635                 640 


Gly Phe Gln Gly Cys Leu Ala Ser Val Asp Leu Asn Gly Arg Leu Pro 
                645                 650                 655     


Asp Leu Ile Asn Asp Ala Leu His Arg Ser Gly Gln Ile Glu Arg Gly 
            660                 665                 670         


Cys Glu Gly Pro Ser Thr Thr Cys Gln Glu Asp Ser Cys Ala Asn Gln 
        675                 680                 685             


Gly Val Cys Met Gln Gln Trp Glu Gly Phe Thr Cys Asp Cys Ser Met 
    690                 695                 700                 


Thr Ser Tyr Ser Gly Asn Gln Cys Asn Asp Pro Gly Ala Thr Tyr Ile 
705                 710                 715                 720 


Phe Gly Lys Ser Gly Gly Leu Ile Leu Tyr Thr Trp Pro Ala Asn Asp 
                725                 730                 735     


Arg Pro Ser Thr Arg Ser Asp Arg Leu Ala Val Gly Phe Ser Thr Thr 
            740                 745                 750         


Val Lys Asp Gly Ile Leu Val Arg Ile Asp Ser Ala Pro Gly Leu Gly 
        755                 760                 765             


Asp Phe Leu Gln Leu His Ile Glu Gln Gly Lys Ile Gly Val Val Phe 
    770                 775                 780                 


Asn Ile Gly Thr Val Asp Ile Ser Ile Lys Glu Glu Arg Thr Pro Val 
785                 790                 795                 800 


Asn Asp Gly Lys Tyr His Val Val Arg Phe Thr Arg Asn Gly Gly Asn 
                805                 810                 815     


Ala Thr Leu Gln Val Asp Asn Trp Pro Val Asn Glu His Tyr Pro Thr 
            820                 825                 830         


Gly Arg Gln Leu Thr Ile Phe Asn Thr Gln Ala Gln Ile Ala Ile Gly 
        835                 840                 845             


Gly Lys Asp Lys Gly Arg Leu Phe Gln Gly Gln Leu Ser Gly Leu Tyr 
    850                 855                 860                 


Tyr Asp Gly Leu Lys Val Leu Asn Met Ala Ala Glu Asn Asn Pro Asn 
865                 870                 875                 880 


Ile Lys Ile Asn Gly Ser Val Arg Leu Val Gly Glu Val Pro Ser Ile 
                885                 890                 895     


Leu Gly Thr Thr Gln Thr Thr Ser Met Pro Pro Glu Met Ser Thr Thr 
            900                 905                 910         


Val Met Glu Thr Thr Thr Thr Met Ala Thr Thr Thr Thr Arg Lys Asn 
        915                 920                 925             


Arg Ser Thr Ala Ser Ile Gln Pro Thr Ser Asp Asp Leu Val Ser Ser 
    930                 935                 940                 


Ala Glu Cys Ser Ser Asp Asp Glu Asp Phe Val Glu Cys Glu Pro Ser 
945                 950                 955                 960 


Thr Ala Asn Pro Thr Glu Pro Gly Ile Arg Arg Val Pro Gly Ala Ser 
                965                 970                 975     


Glu Val Ile Arg Glu Ser Ser Ser Thr Thr Gly Met Val Val Gly Ile 
            980                 985                 990         


Val Ala Ala Ala Ala Leu Cys Ile  Leu Ile Leu Leu Tyr  Ala Met Tyr 
        995                 1000                 1005             


Lys Tyr  Arg Asn Arg Asp Glu  Gly Ser Tyr Gln Val  Asp Glu Thr 
    1010                 1015                 1020             


Arg Asn  Tyr Ile Ser Asn Ser  Ala Gln Ser Asn Gly  Thr Leu Met 
    1025                 1030                 1035             


Lys Glu  Lys Gln Gln Ser Ser  Lys Ser Gly His Lys  Lys Gln Lys 
    1040                 1045                 1050             


Asn Lys  Asp Arg Glu Tyr Tyr  Val 
    1055                 1060     


<210>  3130
<211>  663
<212>  PRT
<213>  Homo sapiens

<400>  3130

Met Ser Ala Arg Leu Pro Val Leu Ser Pro Pro Arg Trp Pro Arg Leu 
1               5                   10                  15      


Leu Leu Leu Ser Leu Leu Leu Leu Gly Ala Val Pro Gly Pro Arg Arg 
            20                  25                  30          


Ser Gly Ala Phe Tyr Leu Pro Gly Leu Ala Pro Val Asn Phe Cys Asp 
        35                  40                  45              


Glu Glu Lys Lys Ser Asp Glu Cys Lys Ala Glu Ile Glu Leu Phe Val 
    50                  55                  60                  


Asn Arg Leu Asp Ser Val Glu Ser Val Leu Pro Tyr Glu Tyr Thr Ala 
65                  70                  75                  80  


Phe Asp Phe Cys Gln Ala Ser Glu Gly Lys Arg Pro Ser Glu Asn Leu 
                85                  90                  95      


Gly Gln Val Leu Phe Gly Glu Arg Ile Glu Pro Ser Pro Tyr Lys Phe 
            100                 105                 110         


Thr Phe Asn Lys Lys Glu Thr Cys Lys Leu Val Cys Thr Lys Thr Tyr 
        115                 120                 125             


His Thr Glu Lys Ala Glu Asp Lys Gln Lys Leu Glu Phe Leu Lys Lys 
    130                 135                 140                 


Ser Met Leu Leu Asn Tyr Gln His His Trp Ile Val Asp Asn Met Pro 
145                 150                 155                 160 


Val Thr Trp Cys Tyr Asp Val Glu Asp Gly Gln Arg Phe Cys Asn Pro 
                165                 170                 175     


Gly Phe Pro Ile Gly Cys Tyr Ile Thr Asp Lys Gly His Ala Lys Asp 
            180                 185                 190         


Ala Cys Val Ile Ser Ser Asp Phe His Glu Arg Asp Thr Phe Tyr Ile 
        195                 200                 205             


Phe Asn His Val Asp Ile Lys Ile Tyr Tyr His Val Val Glu Thr Gly 
    210                 215                 220                 


Ser Met Gly Ala Arg Leu Val Ala Ala Lys Leu Glu Pro Lys Ser Phe 
225                 230                 235                 240 


Lys His Thr His Ile Asp Lys Pro Asp Cys Ser Gly Pro Pro Met Asp 
                245                 250                 255     


Ile Ser Asn Lys Ala Ser Gly Glu Ile Lys Ile Ala Tyr Thr Tyr Ser 
            260                 265                 270         


Val Ser Phe Glu Glu Asp Asp Lys Ile Arg Trp Ala Ser Arg Trp Asp 
        275                 280                 285             


Tyr Ile Leu Glu Ser Met Pro His Thr His Ile Gln Trp Phe Ser Ile 
    290                 295                 300                 


Met Asn Ser Leu Val Ile Val Leu Phe Leu Ser Gly Met Val Ala Met 
305                 310                 315                 320 


Ile Met Leu Arg Thr Leu His Lys Asp Ile Ala Arg Tyr Asn Gln Met 
                325                 330                 335     


Asp Ser Thr Glu Asp Ala Gln Glu Glu Phe Gly Trp Lys Leu Val His 
            340                 345                 350         


Gly Asp Ile Phe Arg Pro Pro Arg Lys Gly Met Leu Leu Ser Val Phe 
        355                 360                 365             


Leu Gly Ser Gly Thr Gln Ile Leu Ile Met Thr Phe Val Thr Leu Phe 
    370                 375                 380                 


Phe Ala Cys Leu Gly Phe Leu Ser Pro Ala Asn Arg Gly Ala Leu Met 
385                 390                 395                 400 


Thr Cys Ala Val Val Leu Trp Val Leu Leu Gly Thr Pro Ala Gly Tyr 
                405                 410                 415     


Val Ala Ala Arg Phe Tyr Lys Ser Phe Gly Gly Glu Lys Trp Lys Thr 
            420                 425                 430         


Asn Val Leu Leu Thr Ser Phe Leu Cys Pro Gly Ile Val Phe Ala Asp 
        435                 440                 445             


Phe Phe Ile Met Asn Leu Ile Leu Trp Gly Glu Gly Ser Ser Ala Ala 
    450                 455                 460                 


Ile Pro Phe Gly Thr Leu Val Ala Ile Leu Ala Leu Trp Phe Cys Ile 
465                 470                 475                 480 


Ser Val Pro Leu Thr Phe Ile Gly Ala Tyr Phe Gly Phe Lys Lys Asn 
                485                 490                 495     


Ala Ile Glu His Pro Val Arg Thr Asn Gln Ile Pro Arg Gln Ile Pro 
            500                 505                 510         


Glu Gln Ser Phe Tyr Thr Lys Pro Leu Pro Gly Ile Ile Met Gly Gly 
        515                 520                 525             


Ile Leu Pro Phe Gly Cys Ile Phe Ile Gln Leu Phe Phe Ile Leu Asn 
    530                 535                 540                 


Ser Ile Trp Ser His Gln Met Tyr Tyr Met Phe Gly Phe Leu Phe Leu 
545                 550                 555                 560 


Val Phe Ile Ile Leu Val Ile Thr Cys Ser Glu Ala Thr Ile Leu Leu 
                565                 570                 575     


Cys Tyr Phe His Leu Cys Ala Glu Asp Tyr His Trp Gln Trp Arg Ser 
            580                 585                 590         


Phe Leu Thr Ser Gly Phe Thr Ala Val Tyr Phe Leu Ile Tyr Ala Val 
        595                 600                 605             


His Tyr Phe Phe Ser Lys Leu Gln Ile Thr Gly Thr Ala Ser Thr Ile 
    610                 615                 620                 


Leu Tyr Phe Gly Tyr Thr Met Ile Met Val Leu Ile Phe Phe Leu Phe 
625                 630                 635                 640 


Thr Gly Thr Ile Gly Phe Phe Ala Cys Phe Trp Phe Val Thr Lys Ile 
                645                 650                 655     


Tyr Ser Val Val Lys Val Asp 
            660             


<210>  3131
<211>  1477
<212>  PRT
<213>  Homo sapiens

<400>  3131

Met Gly Thr Ala Leu Leu Gln Arg Gly Gly Cys Phe Leu Leu Cys Leu 
1               5                   10                  15      


Ser Leu Leu Leu Leu Gly Cys Trp Ala Glu Leu Gly Ser Gly Leu Glu 
            20                  25                  30          


Phe Pro Gly Ala Glu Gly Gln Trp Thr Arg Phe Pro Lys Trp Asn Ala 
        35                  40                  45              


Cys Cys Glu Ser Glu Met Ser Phe Gln Leu Lys Thr Arg Ser Ala Arg 
    50                  55                  60                  


Gly Leu Val Leu Tyr Phe Asp Asp Glu Gly Phe Cys Asp Phe Leu Glu 
65                  70                  75                  80  


Leu Ile Leu Thr Arg Gly Gly Arg Leu Gln Leu Ser Phe Ser Ile Phe 
                85                  90                  95      


Cys Ala Glu Pro Ala Thr Leu Leu Ala Asp Thr Pro Val Asn Asp Gly 
            100                 105                 110         


Ala Trp His Ser Val Arg Ile Arg Arg Gln Phe Arg Asn Thr Thr Leu 
        115                 120                 125             


Phe Ile Asp Gln Val Glu Ala Lys Trp Val Glu Val Lys Ser Lys Arg 
    130                 135                 140                 


Arg Asp Met Thr Val Phe Ser Gly Leu Phe Val Gly Gly Leu Pro Pro 
145                 150                 155                 160 


Glu Leu Arg Ala Ala Ala Leu Lys Leu Thr Leu Ala Ser Val Arg Glu 
                165                 170                 175     


Arg Glu Pro Phe Lys Gly Trp Ile Arg Asp Val Arg Val Asn Ser Ser 
            180                 185                 190         


Gln Val Leu Pro Val Asp Ser Gly Glu Val Lys Leu Asp Asp Glu Pro 
        195                 200                 205             


Pro Asn Ser Gly Gly Gly Ser Pro Cys Glu Ala Gly Glu Glu Gly Glu 
    210                 215                 220                 


Gly Gly Val Cys Leu Asn Gly Gly Val Cys Ser Val Val Asp Asp Gln 
225                 230                 235                 240 


Ala Val Cys Asp Cys Ser Arg Thr Gly Phe Arg Gly Lys Asp Cys Ser 
                245                 250                 255     


Gln Glu Asp Asn Asn Val Glu Gly Leu Ala His Leu Met Met Gly Asp 
            260                 265                 270         


Gln Gly Lys Ser Lys Gly Lys Glu Glu Tyr Ile Ala Thr Phe Lys Gly 
        275                 280                 285             


Ser Glu Tyr Phe Cys Tyr Asp Leu Ser Gln Asn Pro Ile Gln Ser Ser 
    290                 295                 300                 


Ser Asp Glu Ile Thr Leu Ser Phe Lys Thr Leu Gln Arg Asn Gly Leu 
305                 310                 315                 320 


Met Leu His Thr Gly Lys Ser Ala Asp Tyr Val Asn Leu Ala Leu Lys 
                325                 330                 335     


Asn Gly Ala Val Ser Leu Val Ile Asn Leu Gly Ser Gly Ala Phe Glu 
            340                 345                 350         


Ala Leu Val Glu Pro Val Asn Gly Lys Phe Asn Asp Asn Ala Trp His 
        355                 360                 365             


Asp Val Lys Val Thr Arg Asn Leu Arg Gln His Ser Gly Ile Gly His 
    370                 375                 380                 


Ala Met Val Thr Ile Ser Val Asp Gly Ile Leu Thr Thr Thr Gly Tyr 
385                 390                 395                 400 


Thr Gln Glu Asp Tyr Thr Met Leu Gly Ser Asp Asp Phe Phe Tyr Val 
                405                 410                 415     


Gly Gly Ser Pro Ser Thr Ala Asp Leu Pro Gly Ser Pro Val Ser Asn 
            420                 425                 430         


Asn Phe Met Gly Cys Leu Lys Glu Val Val Tyr Lys Asn Asn Asp Val 
        435                 440                 445             


Arg Leu Glu Leu Ser Arg Leu Ala Lys Gln Gly Asp Pro Lys Met Lys 
    450                 455                 460                 


Ile His Gly Val Val Ala Phe Lys Cys Glu Asn Val Ala Thr Leu Asp 
465                 470                 475                 480 


Pro Ile Thr Phe Glu Thr Pro Glu Ser Phe Ile Ser Leu Pro Lys Trp 
                485                 490                 495     


Asn Ala Lys Lys Thr Gly Ser Ile Ser Phe Asp Phe Arg Thr Thr Glu 
            500                 505                 510         


Pro Asn Gly Leu Ile Leu Phe Ser His Gly Lys Pro Arg His Gln Lys 
        515                 520                 525             


Asp Ala Lys His Pro Gln Met Ile Lys Val Asp Phe Phe Ala Ile Glu 
    530                 535                 540                 


Met Leu Asp Gly His Leu Tyr Leu Leu Leu Asp Met Gly Ser Gly Thr 
545                 550                 555                 560 


Ile Lys Ile Lys Ala Leu Leu Lys Lys Val Asn Asp Gly Glu Trp Tyr 
                565                 570                 575     


His Val Asp Phe Gln Arg Asp Gly Arg Ser Gly Thr Ile Ser Val Asn 
            580                 585                 590         


Thr Leu Arg Thr Pro Tyr Thr Ala Pro Gly Glu Ser Glu Ile Leu Asp 
        595                 600                 605             


Leu Asp Asp Glu Leu Tyr Leu Gly Gly Leu Pro Glu Asn Lys Ala Gly 
    610                 615                 620                 


Leu Val Phe Pro Thr Glu Val Trp Thr Ala Leu Leu Asn Tyr Gly Tyr 
625                 630                 635                 640 


Val Gly Cys Ile Arg Asp Leu Phe Ile Asp Gly Gln Ser Lys Asp Ile 
                645                 650                 655     


Arg Gln Met Ala Glu Val Gln Ser Thr Ala Gly Val Lys Pro Ser Cys 
            660                 665                 670         


Ser Lys Glu Thr Ala Lys Pro Cys Leu Ser Asn Pro Cys Lys Asn Asn 
        675                 680                 685             


Gly Met Cys Arg Asp Gly Trp Asn Arg Tyr Val Cys Asp Cys Ser Gly 
    690                 695                 700                 


Thr Gly Tyr Leu Gly Arg Ser Cys Glu Arg Glu Ala Thr Val Leu Ser 
705                 710                 715                 720 


Tyr Asp Gly Ser Met Phe Met Lys Ile Gln Leu Pro Val Val Met His 
                725                 730                 735     


Thr Glu Ala Glu Asp Val Ser Leu Arg Phe Arg Ser Gln Arg Ala Tyr 
            740                 745                 750         


Gly Ile Leu Met Ala Thr Thr Ser Arg Asp Ser Ala Asp Thr Leu Arg 
        755                 760                 765             


Leu Glu Leu Asp Ala Gly Arg Val Lys Leu Thr Val Asn Leu Asp Cys 
    770                 775                 780                 


Ile Arg Ile Asn Cys Asn Ser Ser Lys Gly Pro Glu Thr Leu Phe Ala 
785                 790                 795                 800 


Gly Tyr Asn Leu Asn Asp Asn Glu Trp His Thr Val Arg Val Val Arg 
                805                 810                 815     


Arg Gly Lys Ser Leu Lys Leu Thr Val Asp Asp Gln Gln Ala Met Thr 
            820                 825                 830         


Gly Gln Met Ala Gly Asp His Thr Arg Leu Glu Phe His Asn Ile Glu 
        835                 840                 845             


Thr Gly Ile Ile Thr Glu Arg Arg Tyr Leu Ser Ser Val Pro Ser Asn 
    850                 855                 860                 


Phe Ile Gly His Leu Gln Ser Leu Thr Phe Asn Gly Met Ala Tyr Ile 
865                 870                 875                 880 


Asp Leu Cys Lys Asn Gly Asp Ile Asp Tyr Cys Glu Leu Asn Ala Arg 
                885                 890                 895     


Phe Gly Phe Arg Asn Ile Ile Ala Asp Pro Val Thr Phe Lys Thr Lys 
            900                 905                 910         


Ser Ser Tyr Val Ala Leu Ala Thr Leu Gln Ala Tyr Thr Ser Met His 
        915                 920                 925             


Leu Phe Phe Gln Phe Lys Thr Thr Ser Leu Asp Gly Leu Ile Leu Tyr 
    930                 935                 940                 


Asn Ser Gly Asp Gly Asn Asp Phe Ile Val Val Glu Leu Val Lys Gly 
945                 950                 955                 960 


Tyr Leu His Tyr Val Phe Asp Leu Gly Asn Gly Ala Asn Leu Ile Lys 
                965                 970                 975     


Gly Ser Ser Asn Lys Pro Leu Asn Asp Asn Gln Trp His Asn Val Met 
            980                 985                 990         


Ile Ser Arg Asp Thr Ser Asn Leu  His Thr Val Lys Ile  Asp Thr Lys 
        995                 1000                 1005             


Ile Thr  Thr Gln Ile Thr Ala  Gly Ala Arg Asn Leu  Asp Leu Lys 
    1010                 1015                 1020             


Ser Asp  Leu Tyr Ile Gly Gly  Val Ala Lys Glu Thr  Tyr Lys Ser 
    1025                 1030                 1035             


Leu Pro  Lys Leu Val His Ala  Lys Glu Gly Phe Gln  Gly Cys Leu 
    1040                 1045                 1050             


Ala Ser  Val Asp Leu Asn Gly  Arg Leu Pro Asp Leu  Ile Ser Asp 
    1055                 1060                 1065             


Ala Leu  Phe Cys Asn Gly Gln  Ile Glu Arg Gly Cys  Glu Gly Pro 
    1070                 1075                 1080             


Ser Thr  Thr Cys Gln Glu Asp  Ser Cys Ser Asn Gln  Gly Val Cys 
    1085                 1090                 1095             


Leu Gln  Gln Trp Asp Gly Phe  Ser Cys Asp Cys Ser  Met Thr Ser 
    1100                 1105                 1110             


Phe Ser  Gly Pro Leu Cys Asn  Asp Pro Gly Thr Thr  Tyr Ile Phe 
    1115                 1120                 1125             


Ser Lys  Gly Gly Gly Gln Ile  Thr Tyr Lys Trp Pro  Pro Asn Asp 
    1130                 1135                 1140             


Arg Pro  Ser Thr Arg Ala Asp  Arg Leu Ala Ile Gly  Phe Ser Thr 
    1145                 1150                 1155             


Val Gln  Lys Glu Ala Val Leu  Val Arg Val Asp Ser  Ser Ser Gly 
    1160                 1165                 1170             


Leu Gly  Asp Tyr Leu Glu Leu  His Ile His Gln Gly  Lys Ile Gly 
    1175                 1180                 1185             


Val Lys  Phe Asn Val Gly Thr  Asp Asp Ile Ala Ile  Glu Glu Ser 
    1190                 1195                 1200             


Asn Ala  Ile Ile Asn Asp Gly  Lys Tyr His Val Val  Arg Phe Thr 
    1205                 1210                 1215             


Arg Ser  Gly Gly Asn Ala Thr  Leu Gln Val Asp Ser  Trp Pro Val 
    1220                 1225                 1230             


Ile Glu  Arg Tyr Pro Ala Gly  Arg Gln Leu Thr Ile  Phe Asn Ser 
    1235                 1240                 1245             


Gln Ala  Thr Ile Ile Ile Gly  Gly Lys Glu Gln Gly  Gln Pro Phe 
    1250                 1255                 1260             


Gln Gly  Gln Leu Ser Gly Leu  Tyr Tyr Asn Gly Leu  Lys Val Leu 
    1265                 1270                 1275             


Asn Met  Ala Ala Glu Asn Asp  Ala Asn Ile Ala Ile  Val Gly Asn 
    1280                 1285                 1290             


Val Arg  Leu Val Gly Glu Val  Pro Ser Ser Met Thr  Thr Glu Ser 
    1295                 1300                 1305             


Thr Ala  Thr Ala Met Gln Ser  Glu Met Ser Thr Ser  Ile Met Glu 
    1310                 1315                 1320             


Thr Thr  Thr Thr Leu Ala Thr  Ser Thr Ala Arg Arg  Gly Lys Pro 
    1325                 1330                 1335             


Pro Thr  Lys Glu Pro Ile Ser  Gln Thr Thr Asp Asp  Ile Leu Val 
    1340                 1345                 1350             


Ala Ser  Ala Glu Cys Pro Ser  Asp Asp Glu Asp Ile  Asp Pro Cys 
    1355                 1360                 1365             


Glu Pro  Ser Ser Gly Gly Leu  Ala Asn Pro Thr Arg  Ala Gly Gly 
    1370                 1375                 1380             


Arg Glu  Pro Tyr Pro Gly Ser  Ala Glu Val Ile Arg  Glu Ser Ser 
    1385                 1390                 1395             


Ser Thr  Thr Gly Met Val Val  Gly Ile Val Ala Ala  Ala Ala Leu 
    1400                 1405                 1410             


Cys Ile  Leu Ile Leu Leu Tyr  Ala Met Tyr Lys Tyr  Arg Asn Arg 
    1415                 1420                 1425             


Asp Glu  Gly Ser Tyr His Val  Asp Glu Ser Arg Asn  Tyr Ile Ser 
    1430                 1435                 1440             


Asn Ser  Ala Gln Ser Asn Gly  Ala Val Val Lys Glu  Lys Gln Pro 
    1445                 1450                 1455             


Ser Ser  Ala Lys Ser Ser Asn  Lys Asn Lys Lys Asn  Lys Asp Lys 
    1460                 1465                 1470             


Glu Tyr  Tyr Val 
    1475         


<210>  3132
<211>  1230
<212>  PRT
<213>  Homo sapiens

<400>  3132

Met Ile Lys Thr Glu Lys Ser Tyr Pro Glu Arg Arg Leu Arg Gly Val 
1               5                   10                  15      


Leu Glu Glu Leu Ser Cys Gly Cys Cys Arg Phe Leu Ser Leu Ala Asp 
            20                  25                  30          


Lys Asp Gln Gly His Ser Ser Arg Thr Arg Leu Asp Arg Glu Arg Leu 
        35                  40                  45              


Lys Ser Cys Met Arg Glu Leu Glu Asn Met Gly Gln Gln Ala Arg Met 
    50                  55                  60                  


Leu Arg Ala Gln Val Lys Arg His Thr Val Arg Asp Lys Leu Arg Leu 
65                  70                  75                  80  


Cys Gln Asn Phe Leu Gln Lys Leu Arg Phe Leu Ala Asp Glu Pro Gln 
                85                  90                  95      


His Ser Ile Pro Asp Ile Phe Ile Trp Met Met Ser Asn Asn Lys Arg 
            100                 105                 110         


Val Ala Tyr Ala Arg Val Pro Ser Lys Asp Leu Leu Phe Ser Ile Val 
        115                 120                 125             


Glu Glu Glu Thr Gly Lys Asp Cys Ala Lys Val Lys Thr Leu Phe Leu 
    130                 135                 140                 


Lys Leu Pro Gly Lys Arg Gly Phe Gly Ser Ala Gly Trp Thr Val Gln 
145                 150                 155                 160 


Ala Lys Val Glu Leu Tyr Leu Trp Leu Gly Leu Ser Lys Gln Arg Lys 
                165                 170                 175     


Glu Phe Leu Cys Gly Leu Pro Cys Gly Phe Gln Glu Val Lys Ala Ala 
            180                 185                 190         


Gln Gly Leu Gly Leu His Ala Phe Pro Pro Val Ser Leu Val Tyr Thr 
        195                 200                 205             


Lys Lys Gln Ala Phe Gln Leu Arg Ala His Met Tyr Gln Ala Arg Ser 
    210                 215                 220                 


Leu Phe Ala Ala Asp Ser Ser Gly Leu Ser Asp Pro Phe Ala Arg Val 
225                 230                 235                 240 


Phe Phe Ile Asn Gln Ser Gln Cys Thr Glu Val Leu Asn Glu Thr Leu 
                245                 250                 255     


Cys Pro Thr Trp Asp Gln Met Leu Val Phe Asp Asn Leu Glu Leu Tyr 
            260                 265                 270         


Gly Glu Ala His Glu Leu Arg Asp Asp Pro Pro Ile Ile Val Ile Glu 
        275                 280                 285             


Ile Tyr Asp Gln Asp Ser Met Gly Lys Ala Asp Phe Met Gly Arg Thr 
    290                 295                 300                 


Phe Ala Lys Pro Leu Val Lys Met Ala Asp Glu Ala Tyr Cys Pro Pro 
305                 310                 315                 320 


Arg Phe Pro Pro Gln Leu Glu Tyr Tyr Gln Ile Tyr Arg Gly Asn Ala 
                325                 330                 335     


Thr Ala Gly Asp Leu Leu Ala Ala Phe Glu Leu Leu Gln Ile Gly Pro 
            340                 345                 350         


Ala Gly Lys Ala Asp Leu Pro Pro Ile Asn Gly Pro Val Asp Val Asp 
        355                 360                 365             


Arg Gly Pro Ile Met Pro Val Pro Met Gly Ile Arg Pro Val Leu Ser 
    370                 375                 380                 


Lys Tyr Arg Val Glu Val Leu Phe Trp Gly Leu Arg Asp Leu Lys Arg 
385                 390                 395                 400 


Val Asn Leu Ala Gln Val Asp Arg Pro Arg Val Asp Ile Glu Cys Ala 
                405                 410                 415     


Gly Lys Gly Val Gln Ser Ser Leu Ile His Asn Tyr Lys Lys Asn Pro 
            420                 425                 430         


Asn Phe Asn Thr Leu Val Lys Trp Phe Glu Val Asp Leu Pro Glu Asn 
        435                 440                 445             


Glu Leu Leu His Pro Pro Leu Asn Ile Arg Val Val Asp Cys Arg Ala 
    450                 455                 460                 


Phe Gly Arg Tyr Thr Leu Val Gly Ser His Ala Val Ser Ser Leu Arg 
465                 470                 475                 480 


Arg Phe Ile Tyr Arg Pro Pro Asp Arg Ser Ala Pro Ser Trp Asn Thr 
                485                 490                 495     


Thr Gly Glu Val Val Val Thr Met Glu Pro Glu Val Pro Ile Lys Lys 
            500                 505                 510         


Leu Glu Thr Met Val Lys Leu Asp Ala Thr Ser Glu Ala Val Val Lys 
        515                 520                 525             


Val Asp Val Ala Glu Glu Glu Lys Glu Lys Lys Lys Lys Lys Lys Gly 
    530                 535                 540                 


Thr Ala Glu Glu Pro Glu Glu Glu Glu Pro Asp Glu Ser Met Leu Asp 
545                 550                 555                 560 


Trp Trp Ser Lys Tyr Phe Ala Ser Ile Asp Thr Met Lys Glu Gln Leu 
                565                 570                 575     


Arg Gln Gln Glu Pro Ser Gly Ile Asp Leu Glu Glu Lys Glu Glu Val 
            580                 585                 590         


Asp Asn Thr Glu Gly Leu Lys Gly Ser Met Lys Gly Lys Glu Lys Ala 
        595                 600                 605             


Arg Ala Ala Lys Glu Glu Lys Lys Lys Lys Thr Gln Ser Ser Gly Ser 
    610                 615                 620                 


Gly Gln Gly Ser Glu Ala Pro Glu Lys Lys Lys Pro Lys Ile Asp Glu 
625                 630                 635                 640 


Leu Lys Val Tyr Pro Lys Glu Leu Glu Ser Glu Phe Asp Asn Phe Glu 
                645                 650                 655     


Asp Trp Leu His Thr Phe Asn Leu Leu Arg Gly Lys Thr Gly Asp Asp 
            660                 665                 670         


Glu Asp Gly Ser Thr Glu Glu Glu Arg Ile Val Gly Arg Phe Lys Gly 
        675                 680                 685             


Ser Leu Cys Val Tyr Lys Val Pro Leu Pro Glu Asp Val Ser Arg Glu 
    690                 695                 700                 


Ala Gly Tyr Asp Ser Thr Tyr Gly Met Phe Gln Gly Ile Pro Ser Asn 
705                 710                 715                 720 


Asp Pro Ile Asn Val Leu Val Arg Val Tyr Val Val Arg Ala Thr Asp 
                725                 730                 735     


Leu His Pro Ala Asp Ile Asn Gly Lys Ala Asp Pro Tyr Ile Ala Ile 
            740                 745                 750         


Arg Leu Gly Lys Thr Asp Ile Arg Asp Lys Glu Asn Tyr Ile Ser Lys 
        755                 760                 765             


Gln Leu Asn Pro Val Phe Gly Lys Ser Phe Asp Ile Glu Ala Ser Phe 
    770                 775                 780                 


Pro Met Glu Ser Met Leu Thr Val Ala Val Tyr Asp Trp Asp Leu Val 
785                 790                 795                 800 


Gly Thr Asp Asp Leu Ile Gly Glu Thr Lys Ile Asp Leu Glu Asn Arg 
                805                 810                 815     


Phe Tyr Ser Lys His Arg Ala Thr Cys Gly Ile Ala Gln Thr Tyr Ser 
            820                 825                 830         


Thr His Gly Tyr Asn Ile Trp Arg Asp Pro Met Lys Pro Ser Gln Ile 
        835                 840                 845             


Leu Thr Arg Leu Cys Lys Asp Gly Lys Val Asp Gly Pro His Phe Gly 
    850                 855                 860                 


Pro Pro Gly Arg Val Lys Val Ala Asn Arg Val Phe Thr Gly Pro Ser 
865                 870                 875                 880 


Glu Ile Glu Asp Glu Asn Gly Gln Arg Lys Pro Thr Asp Glu His Val 
                885                 890                 895     


Ala Leu Leu Ala Leu Arg His Trp Glu Asp Ile Pro Arg Ala Gly Cys 
            900                 905                 910         


Arg Leu Val Pro Glu His Val Glu Thr Arg Pro Leu Leu Asn Pro Asp 
        915                 920                 925             


Lys Pro Gly Ile Glu Gln Gly Arg Leu Glu Leu Trp Val Asp Met Phe 
    930                 935                 940                 


Pro Met Asp Met Pro Ala Pro Gly Thr Pro Leu Asp Ile Ser Pro Arg 
945                 950                 955                 960 


Lys Pro Lys Lys Tyr Glu Leu Arg Val Ile Ile Trp Asn Thr Asp Glu 
                965                 970                 975     


Val Val Leu Glu Asp Asp Asp Phe Phe Thr Gly Glu Lys Ser Ser Asp 
            980                 985                 990         


Ile Phe Val Arg Gly Trp Leu Lys  Gly Gln Gln Glu Asp  Lys Gln Asp 
        995                 1000                 1005             


Thr Asp  Val His Tyr His Ser  Leu Thr Gly Glu Gly  Asn Phe Asn 
    1010                 1015                 1020             


Trp Arg  Tyr Leu Phe Pro Phe  Asp Tyr Leu Ala Ala  Glu Glu Lys 
    1025                 1030                 1035             


Ile Val  Ile Ser Lys Lys Glu  Ser Met Phe Ser Trp  Asp Glu Thr 
    1040                 1045                 1050             


Glu Tyr  Lys Ile Pro Ala Arg  Leu Thr Leu Gln Ile  Trp Asp Ala 
    1055                 1060                 1065             


Asp His  Phe Ser Ala Asp Asp  Phe Leu Gly Ala Ile  Glu Leu Asp 
    1070                 1075                 1080             


Leu Asn  Arg Phe Pro Arg Gly  Ala Lys Thr Ala Lys  Gln Cys Thr 
    1085                 1090                 1095             


Met Glu  Met Ala Thr Gly Glu  Val Asp Val Pro Leu  Val Ser Ile 
    1100                 1105                 1110             


Phe Lys  Gln Lys Arg Val Lys  Gly Trp Trp Pro Leu  Leu Ala Arg 
    1115                 1120                 1125             


Asn Glu  Asn Asp Glu Phe Glu  Leu Thr Gly Lys Val  Glu Ala Glu 
    1130                 1135                 1140             


Leu His  Leu Leu Thr Ala Glu  Glu Ala Glu Lys Asn  Pro Val Gly 
    1145                 1150                 1155             


Leu Ala  Arg Asn Glu Pro Asp  Pro Leu Glu Lys Pro  Asn Arg Pro 
    1160                 1165                 1170             


Asp Thr  Ser Phe Ile Trp Phe  Leu Asn Pro Leu Lys  Ser Ala Arg 
    1175                 1180                 1185             


Tyr Phe  Leu Trp His Thr Tyr  Arg Trp Leu Leu Leu  Lys Leu Leu 
    1190                 1195                 1200             


Leu Leu  Leu Leu Leu Leu Leu  Leu Leu Ala Leu Phe  Leu Tyr Ser 
    1205                 1210                 1215             


Val Pro  Gly Tyr Leu Val Lys  Lys Ile Leu Gly Ala  
    1220                 1225                 1230 


<210>  3133
<211>  594
<212>  PRT
<213>  Homo sapiens

<400>  3133

Met Ala Gly Glu Glu Asn Phe Lys Glu Glu Leu Arg Ser Gln Asp Ala 
1               5                   10                  15      


Ser Arg Asn Leu Asn Gln His Glu Val Ala Gly His Pro His Ser Trp 
            20                  25                  30          


Ser Leu Glu Met Leu Leu Arg Arg Leu Arg Ala Val His Thr Lys Gln 
        35                  40                  45              


Asp Asp Lys Phe Ala Asn Leu Leu Asp Ala Val Gly Glu Phe Gly Thr 
    50                  55                  60                  


Phe Gln Gln Arg Leu Val Ala Leu Thr Phe Ile Pro Ser Ile Met Ser 
65                  70                  75                  80  


Ala Phe Phe Met Phe Ala Asp His Phe Val Phe Thr Ala Gln Lys Pro 
                85                  90                  95      


Tyr Cys Asn Thr Ser Trp Ile Leu Ala Val Gly Pro His Leu Ser Lys 
            100                 105                 110         


Ala Glu Gln Leu Asn Leu Thr Ile Pro Gln Ala Pro Asn Gly Ser Phe 
        115                 120                 125             


Leu Thr Cys Phe Met Tyr Leu Pro Val Pro Trp Asn Leu Asp Ser Ile 
    130                 135                 140                 


Ile Gln Phe Gly Leu Asn Asp Thr Asp Thr Cys Gln Asp Gly Trp Ile 
145                 150                 155                 160 


Tyr Pro Asp Ala Lys Lys Arg Ser Leu Ile Asn Glu Phe Asp Leu Val 
                165                 170                 175     


Cys Gly Met Glu Thr Lys Lys Asp Thr Ala Gln Ile Met Phe Met Ala 
            180                 185                 190         


Gly Leu Pro Ile Gly Ser Leu Ile Phe Arg Leu Ile Thr Asp Lys Met 
        195                 200                 205             


Gly Arg Tyr Pro Ala Ile Leu Leu Ser Leu Leu Gly Leu Ile Ile Phe 
    210                 215                 220                 


Gly Phe Gly Thr Ala Phe Met Asn Ser Phe His Leu Tyr Leu Phe Phe 
225                 230                 235                 240 


Arg Phe Gly Ile Ser Gln Ser Val Val Gly Tyr Ala Ile Ser Ser Ile 
                245                 250                 255     


Ser Leu Ala Thr Glu Trp Leu Val Gly Glu His Arg Ala His Ala Ile 
            260                 265                 270         


Ile Leu Gly His Cys Phe Phe Ala Val Gly Ala Val Leu Leu Thr Gly 
        275                 280                 285             


Ile Ala Tyr Ser Leu Pro His Trp Gln Leu Leu Phe Leu Val Gly Gly 
    290                 295                 300                 


Ile Leu Val Ile Pro Phe Ile Ser Tyr Ile Trp Ile Leu Pro Glu Ser 
305                 310                 315                 320 


Pro Arg Trp Leu Met Met Lys Gly Lys Val Lys Glu Ala Lys Gln Val 
                325                 330                 335     


Leu Cys Tyr Ala Ala Ser Val Asn Lys Lys Thr Ile Pro Ser Asn Leu 
            340                 345                 350         


Leu Asp Glu Leu Gln Leu Pro Arg Lys Lys Val Thr Arg Ala Ser Val 
        355                 360                 365             


Leu Asp Phe Cys Lys Asn Arg Gln Leu Cys Lys Val Thr Leu Val Met 
    370                 375                 380                 


Ser Cys Val Trp Phe Thr Val Ser Tyr Thr Tyr Phe Thr Leu Ser Leu 
385                 390                 395                 400 


Arg Met Arg Glu Leu Gly Val Ser Val His Phe Arg His Val Val Pro 
                405                 410                 415     


Ser Ile Met Glu Val Pro Ala Arg Leu Cys Cys Ile Phe Leu Leu Gln 
            420                 425                 430         


Gln Ile Gly Arg Lys Trp Ser Leu Ala Val Thr Leu Leu Gln Ala Ile 
        435                 440                 445             


Ile Trp Cys Leu Leu Leu Leu Phe Leu Pro Glu Gly Glu Asp Gly Leu 
    450                 455                 460                 


Arg Leu Lys Trp Pro Arg Cys Pro Ala Thr Glu Leu Lys Ser Met Thr 
465                 470                 475                 480 


Ile Leu Val Leu Met Leu Arg Glu Phe Ser Leu Ala Ala Thr Val Thr 
                485                 490                 495     


Val Phe Phe Leu Tyr Thr Ala Glu Leu Leu Pro Thr Val Leu Arg Ala 
            500                 505                 510         


Thr Gly Leu Gly Leu Val Ser Leu Ala Ser Val Ala Gly Ala Ile Leu 
        515                 520                 525             


Ser Leu Thr Ile Ile Ser Gln Thr Pro Ser Leu Leu Pro Ile Phe Leu 
    530                 535                 540                 


Cys Cys Val Leu Ala Ile Val Ala Phe Ser Leu Ser Ser Leu Leu Pro 
545                 550                 555                 560 


Glu Thr Arg Asp Gln Pro Leu Ser Glu Ser Leu Asn His Ser Ser Gln 
                565                 570                 575     


Ile Arg Asn Lys Val Lys Asp Met Lys Thr Lys Glu Thr Ser Ser Asp 
            580                 585                 590         


Asp Val 
        


<210>  3134
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  3134

Met Leu Gly Arg Ser Gly Tyr Arg Ala Leu Pro Leu Gly Asp Phe Asp 
1               5                   10                  15      


Arg Phe Gln Gln Ser Ser Phe Gly Phe Leu Gly Ser Gln Lys Gly Cys 
            20                  25                  30          


Leu Ser Pro Glu Arg Gly Gly Val Gly Thr Gly Ala Asp Val Pro Gln 
        35                  40                  45              


Ser Trp Pro Ser Cys Leu Cys His Gly Leu Ile Ser Phe Leu Gly Phe 
    50                  55                  60                  


Leu Leu Leu Leu Val Thr Phe Pro Ile Ser Gly Trp Phe Ala Leu Lys 
65                  70                  75                  80  


Ile Val Pro Thr Tyr Glu Arg Met Ile Val Phe Arg Leu Gly Arg Ile 
                85                  90                  95      


Arg Thr Pro Gln Gly Pro Gly Met Val Leu Leu Leu Pro Phe Ile Asp 
            100                 105                 110         


Ser Phe Gln Arg Val Asp Leu Arg Thr Arg Ala Phe Asn Val Pro Pro 
        115                 120                 125             


Cys Lys Leu Ala Ser Lys Asp Gly Ala Val Leu Ser Val Gly Ala Asp 
    130                 135                 140                 


Val Gln Phe Arg Ile Trp Asp Pro Val Leu Ser Val Met Thr Val Lys 
145                 150                 155                 160 


Asp Leu Asn Thr Ala Thr Arg Met Thr Ala Gln Asn Ala Met Thr Lys 
                165                 170                 175     


Ala Leu Leu Lys Arg Pro Leu Arg Glu Ile Gln Met Glu Lys Leu Lys 
            180                 185                 190         


Ile Ser Asp Gln Leu Leu Leu Glu Ile Asn Asp Val Thr Arg Ala Trp 
        195                 200                 205             


Gly Leu Glu Val Asp Arg Val Glu Leu Ala Val Glu Ala Val Leu Gln 
    210                 215                 220                 


Pro Pro Gln Asp Ser Pro Ala Gly Pro Asn Leu Asp Ser Thr Leu Gln 
225                 230                 235                 240 


Gln Leu Ala Leu His Phe Leu Gly Gly Ser Met Asn Ser Met Ala Gly 
                245                 250                 255     


Gly Ala Pro Ser Pro Gly Pro Ala Asp Thr Val Glu Met Val Ser Glu 
            260                 265                 270         


Val Glu Pro Pro Ala Pro Gln Val Gly Ala Arg Ser Ser Pro Lys Gln 
        275                 280                 285             


Pro Leu Ala Glu Gly Leu Leu Thr Ala Leu Gln Pro Phe Leu Ser Glu 
    290                 295                 300                 


Ala Leu Val Ser Gln Val Gly Ala Cys Tyr Gln Phe Asn Val Val Leu 
305                 310                 315                 320 


Pro Ser Gly Thr Gln Ser Ala Tyr Phe Leu Asp Leu Thr Thr Gly Arg 
                325                 330                 335     


Gly Arg Val Gly His Gly Val Pro Asp Gly Ile Pro Asp Val Val Val 
            340                 345                 350         


Glu Met Ala Glu Ala Asp Leu Arg Ala Leu Leu Cys Arg Glu Leu Arg 
        355                 360                 365             


Pro Leu Gly Ala Tyr Met Ser Gly Arg Leu Lys Val Lys Gly Asp Leu 
    370                 375                 380                 


Ala Met Ala Met Lys Leu Glu Ala Val Leu Arg Ala Leu Lys 
385                 390                 395             


<210>  3135
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  3135

Met Ile Glu Gln Gln Lys Arg Lys Gly Pro Glu Leu Pro Leu Val Pro 
1               5                   10                  15      


Val Lys Arg Gln Arg His Glu Leu Leu Leu Gly Ala Gly Ser Gly Pro 
            20                  25                  30          


Gly Ala Gly Gln Gln Gln Ala Thr Pro Gly Ala Leu Leu Gln Ala Gly 
        35                  40                  45              


Pro Pro Arg Cys Ser Ser Leu Gln Ala Pro Ile Met Leu Leu Ser Gly 
    50                  55                  60                  


His Glu Gly Glu Val Tyr Cys Cys Lys Phe His Pro Asn Gly Ser Thr 
65                  70                  75                  80  


Leu Ala Ser Ala Gly Phe Asp Arg Leu Ile Leu Leu Trp Asn Val Tyr 
                85                  90                  95      


Gly Asp Cys Asp Asn Tyr Ala Thr Leu Lys Gly His Ser Gly Ala Val 
            100                 105                 110         


Met Glu Leu His Tyr Asn Thr Asp Gly Ser Met Leu Phe Ser Ala Ser 
        115                 120                 125             


Thr Asp Lys Thr Val Ala Val Trp Asp Ser Glu Thr Gly Glu Arg Val 
    130                 135                 140                 


Lys Arg Leu Lys Gly His Thr Ser Phe Val Asn Ser Cys Tyr Pro Ala 
145                 150                 155                 160 


Arg Arg Gly Pro Gln Leu Val Cys Thr Gly Ser Asp Asp Gly Thr Val 
                165                 170                 175     


Lys Leu Trp Asp Ile Arg Lys Lys Ala Ala Ile Gln Thr Phe Gln Asn 
            180                 185                 190         


Thr Tyr Gln Val Leu Ala Val Thr Phe Asn Asp Thr Ser Asp Gln Ile 
        195                 200                 205             


Ile Ser Gly Gly Ile Asp Asn Asp Ile Lys Val Trp Asp Leu Arg Gln 
    210                 215                 220                 


Asn Lys Leu Thr Tyr Thr Met Arg Gly His Ala Asp Ser Val Thr Gly 
225                 230                 235                 240 


Leu Ser Leu Ser Ser Glu Gly Ser Tyr Leu Leu Ser Asn Ala Met Asp 
                245                 250                 255     


Asn Thr Val Arg Val Trp Asp Val Arg Pro Phe Ala Pro Lys Glu Arg 
            260                 265                 270         


Cys Val Lys Ile Phe Gln Gly Asn Val His Asn Phe Glu Lys Asn Leu 
        275                 280                 285             


Leu Arg Cys Ser Trp Ser Pro Asp Gly Ser Lys Ile Ala Ala Gly Ser 
    290                 295                 300                 


Ala Asp Arg Phe Val Tyr Val Trp Asp Thr Thr Ser Arg Arg Ile Leu 
305                 310                 315                 320 


Tyr Lys Leu Pro Gly His Ala Gly Ser Ile Asn Glu Val Ala Phe His 
                325                 330                 335     


Pro Asp Glu Pro Ile Ile Ile Ser Ala Ser Ser Asp Lys Arg Leu Tyr 
            340                 345                 350         


Met Gly Glu Ile Gln 
        355         


<210>  3136
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  3136

Met Ile Leu Leu Val Asn Leu Phe Val Leu Leu Ser Val Val Cys Val 
1               5                   10                  15      


Leu Leu Asn Leu Ala Gly Phe Ile Leu Gly Cys Gln Gly Ala Gln Phe 
            20                  25                  30          


Val Ser Ser Val Pro Arg Cys Asp Leu Val Asp Leu Gly Glu Gly Lys 
        35                  40                  45              


Ile Cys Phe Cys Cys Glu Glu Phe Gln Pro Ala Lys Cys Thr Asp Lys 
    50                  55                  60                  


Glu Asn Ala Leu Lys Leu Phe Pro Val Gln Pro Cys Ser Ala Val His 
65                  70                  75                  80  


Leu Leu Leu Lys Lys Val Leu Phe Ala Leu Cys Ala Leu Asn Ala Leu 
                85                  90                  95      


Thr Thr Thr Val Cys Leu Val Ala Ala Ala Leu Arg Tyr Leu Gln Ile 
            100                 105                 110         


Phe Ala Thr Arg Arg Ser Cys Ile Asp Glu Ser Gln Ile Ser Ala Glu 
        115                 120                 125             


Glu Ala Glu Asp His Gly Arg Ile Pro Asp Pro Asp Asp Phe Val Pro 
    130                 135                 140                 


Pro Val Pro Pro Pro Ser Tyr Phe Ala Thr Phe Tyr Ser Cys Thr Pro 
145                 150                 155                 160 


Arg Met Asn Arg Arg Met Val Gly Pro Asp Val Ile Pro Leu Pro His 
                165                 170                 175     


Ile Tyr Gly Ala Arg Ile Lys Gly Val Glu Val Phe Cys Pro Leu Asp 
            180                 185                 190         


Pro Pro Pro Pro Tyr Glu Ala Val Val Ser Gln Met Asp Gln Glu Gln 
        195                 200                 205             


Gly Ser Ser Phe Gln Met Ser Glu Gly Ser Glu Ala Ala Val Ile Pro 
    210                 215                 220                 


Leu Asp Leu Gly Cys Thr Gln Val Thr Gln Asp Gly Asp Ile Pro Asn 
225                 230                 235                 240 


Ile Pro Ala Glu Glu Asn Ala Ser Thr Ser Thr Pro Ser Ser Thr Leu 
                245                 250                 255     


Val Arg Pro Ile Arg Ser Arg Arg Ala Leu Pro Pro Leu Arg Thr Arg 
            260                 265                 270         


Ser Lys Ser Asp Pro Val Leu His Pro Ser Glu Glu Arg Ala Ala Pro 
        275                 280                 285             


Val Leu Ser Cys Glu Ala Ala Thr Gln Thr Glu Arg Arg Leu Asp Leu 
    290                 295                 300                 


Ala Ala Val Thr Leu Arg Arg Gly Leu Arg Ser Arg Ala Ser Arg Cys 
305                 310                 315                 320 


Arg Pro Arg Ser Leu Ile Asp Tyr Lys Ser Tyr Met Asp Thr Lys Leu 
                325                 330                 335     


Leu Val Ala Arg Phe Leu Glu Gln Ser Ser Cys Thr Met Thr Pro Asp 
            340                 345                 350         


Ile His Glu Leu Val Glu Asn Ile Lys Ser Val Leu Lys Ser Asp Glu 
        355                 360                 365             


Glu His Met Glu Glu Ala Ile Thr Ser Ala Ser Phe Leu Glu Gln Ile 
    370                 375                 380                 


Met Ala Pro Leu Gln Pro Ser Thr Ser Arg Ala His Lys Leu Pro Ser 
385                 390                 395                 400 


Arg Arg Gln Pro Gly Leu Leu His Leu Gln Ser Cys Gly Asp Leu His 
                405                 410                 415     


Thr Phe Thr Pro Ala Gly Arg Pro Arg Ala Glu Arg Arg Pro Arg Arg 
            420                 425                 430         


Val Glu Ala Glu Arg Pro His Ser Leu Ile Gly Val Ile Arg Glu Thr 
        435                 440                 445             


Val Leu 
    450 


<210>  3137
<211>  506
<212>  PRT
<213>  Homo sapiens

<400>  3137

Met Ala Gly Glu Val Ser Ala Ala Thr Gly Arg Phe Ser Leu Glu Arg 
1               5                   10                  15      


Leu Gly Leu Pro Gly Leu Ala Leu Ala Ala Ala Leu Leu Leu Leu Ala 
            20                  25                  30          


Leu Cys Leu Leu Val Arg Arg Thr Arg Arg Pro Gly Glu Pro Pro Leu 
        35                  40                  45              


Ile Lys Gly Trp Leu Pro Tyr Leu Gly Val Val Leu Asn Leu Arg Lys 
    50                  55                  60                  


Asp Pro Leu Arg Phe Met Lys Thr Leu Gln Lys Gln His Gly Asp Thr 
65                  70                  75                  80  


Phe Thr Val Leu Leu Gly Gly Lys Tyr Ile Thr Phe Ile Leu Asp Pro 
                85                  90                  95      


Phe Gln Tyr Gln Leu Val Ile Lys Asn His Lys Gln Leu Ser Phe Arg 
            100                 105                 110         


Val Phe Ser Asn Lys Leu Leu Glu Lys Ala Phe Ser Ile Ser Gln Leu 
        115                 120                 125             


Gln Lys Asn His Asp Met Asn Asp Glu Leu His Leu Cys Tyr Gln Phe 
    130                 135                 140                 


Leu Gln Gly Lys Ser Leu Asp Ile Leu Leu Glu Ser Met Met Gln Asn 
145                 150                 155                 160 


Leu Lys Gln Val Phe Glu Pro Gln Leu Leu Lys Thr Thr Ser Trp Asp 
                165                 170                 175     


Thr Ala Glu Leu Tyr Pro Phe Cys Ser Ser Ile Ile Phe Glu Ile Thr 
            180                 185                 190         


Phe Thr Thr Ile Tyr Gly Lys Val Ile Val Cys Asp Asn Asn Lys Phe 
        195                 200                 205             


Ile Ser Glu Leu Arg Asp Asp Phe Leu Lys Phe Asp Asp Lys Phe Ala 
    210                 215                 220                 


Tyr Leu Val Ser Asn Ile Pro Ile Glu Leu Leu Gly Asn Val Lys Ser 
225                 230                 235                 240 


Ile Arg Glu Lys Ile Ile Lys Cys Phe Ser Ser Glu Lys Leu Ala Lys 
                245                 250                 255     


Met Gln Gly Trp Ser Glu Val Phe Gln Ser Arg Gln Asp Val Leu Glu 
            260                 265                 270         


Lys Tyr Tyr Val His Glu Asp Leu Glu Ile Gly Ala His His Leu Gly 
        275                 280                 285             


Phe Leu Trp Ala Ser Val Ala Asn Thr Ile Pro Thr Met Phe Trp Ala 
    290                 295                 300                 


Met Tyr Tyr Leu Leu Arg His Pro Glu Ala Met Ala Ala Val Arg Asp 
305                 310                 315                 320 


Glu Ile Asp Arg Leu Leu Gln Ser Thr Gly Gln Lys Lys Gly Ser Gly 
                325                 330                 335     


Phe Pro Ile His Leu Thr Arg Glu Gln Leu Asp Ser Leu Ile Cys Leu 
            340                 345                 350         


Glu Ser Ser Ile Phe Glu Ala Leu Arg Leu Ser Ser Tyr Ser Thr Thr 
        355                 360                 365             


Ile Arg Phe Val Glu Glu Asp Leu Thr Leu Ser Ser Glu Thr Gly Asp 
    370                 375                 380                 


Tyr Cys Val Arg Lys Gly Asp Leu Val Ala Ile Phe Pro Pro Val Leu 
385                 390                 395                 400 


His Gly Asp Pro Glu Ile Phe Glu Ala Pro Glu Glu Phe Arg Tyr Asp 
                405                 410                 415     


Arg Phe Ile Glu Asp Gly Lys Lys Lys Thr Thr Phe Phe Lys Arg Gly 
            420                 425                 430         


Lys Lys Leu Lys Cys Tyr Leu Met Pro Phe Gly Thr Gly Thr Ser Lys 
        435                 440                 445             


Cys Pro Gly Arg Phe Phe Ala Leu Met Glu Ile Lys Gln Leu Leu Val 
    450                 455                 460                 


Ile Leu Leu Thr Tyr Phe Asp Leu Glu Ile Ile Asp Asp Lys Pro Ile 
465                 470                 475                 480 


Gly Leu Asn Tyr Ser Arg Leu Leu Phe Gly Ile Gln Tyr Pro Asp Ser 
                485                 490                 495     


Asp Val Leu Phe Arg Tyr Lys Val Lys Ser 
            500                 505     


<210>  3138
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  3138

Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala 
1               5                   10                  15      


Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala 
            20                  25                  30          


Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro 
        35                  40                  45              


Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
    50                  55                  60                  


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
65                  70                  75                  80  


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
                85                  90                  95      


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
            100                 105                 110         


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
        115                 120                 125             


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
    130                 135                 140                 


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
145                 150                 155                 160 


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
                165                 170                 175     


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
            180                 185                 190         


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
        195                 200                 205             


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
    210                 215                 220                 


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
225                 230                 235                 240 


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
                245                 250                 255     


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
            260                 265                 270         


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn 
        275                 280                 285             


Gly His Ala Ala Arg Cys Val Arg Asp Arg Asp Asp Ser Leu Val Cys 
    290                 295                 300                 


Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro 
305                 310                 315                 320 


Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Ala Arg Glu Ala Asn 
                325                 330                 335     


Glu Cys Val Ala Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe 
            340                 345                 350         


Asn Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys 
        355                 360                 365             


Leu Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys 
    370                 375                 380                 


Glu Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile Thr His Arg Lys Ala 
385                 390                 395                 400 


Cys Lys Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys 
                405                 410                 415     


Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly Ile 
            420                 425                 430         


Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro Ile 
        435                 440                 445             


Ala Pro Cys Ile Lys Ile Pro Val Ala Pro Pro Thr Thr Ala Ala Ser 
    450                 455                 460                 


Ser Val Glu Glu Pro Glu Asp Cys Asp Ser Tyr Cys Lys Ala Ser Lys 
465                 470                 475                 480 


Gly Lys Leu Lys Ile Asn Met Lys Lys Tyr Cys Lys Lys Asp Tyr Ala 
                485                 490                 495     


Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys 
            500                 505                 510         


Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile 
        515                 520                 525             


Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys 
    530                 535                 540                 


Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn 
545                 550                 555                 560 


Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser 
                565                 570                 575     


Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe 
            580                 585                 590         


Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala 
        595                 600                 


<210>  3139
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  3139

Met Arg Arg Gly Ala Leu Leu Ala Gly Ala Leu Ala Ala Tyr Ala Ala 
1               5                   10                  15      


Tyr Leu Val Leu Gly Ala Leu Leu Val Ala Arg Leu Glu Gly Pro His 
            20                  25                  30          


Glu Ala Arg Leu Arg Ala Glu Leu Glu Thr Leu Arg Ala Gln Leu Leu 
        35                  40                  45              


Gln Arg Ser Pro Cys Val Ala Ala Pro Ala Leu Asp Ala Phe Val Glu 
    50                  55                  60                  


Arg Val Leu Ala Ala Gly Arg Leu Gly Arg Val Val Leu Ala Asn Ala 
65                  70                  75                  80  


Ser Gly Ser Ala Asn Ala Ser Asp Pro Ala Trp Asp Phe Ala Ser Ala 
                85                  90                  95      


Leu Phe Phe Ala Ser Thr Leu Ile Thr Thr Val Gly Tyr Gly Tyr Thr 
            100                 105                 110         


Thr Pro Leu Thr Asp Ala Gly Lys Ala Phe Ser Ile Ala Phe Ala Leu 
        115                 120                 125             


Leu Gly Val Pro Thr Thr Met Leu Leu Leu Thr Ala Ser Ala Gln Arg 
    130                 135                 140                 


Leu Ser Leu Leu Leu Thr His Val Pro Leu Ser Trp Leu Ser Met Arg 
145                 150                 155                 160 


Trp Gly Trp Asp Pro Arg Arg Ala Ala Cys Trp His Leu Val Ala Leu 
                165                 170                 175     


Leu Gly Val Val Val Thr Val Cys Phe Leu Val Pro Ala Val Ile Phe 
            180                 185                 190         


Ala His Leu Glu Glu Ala Trp Ser Phe Leu Asp Ala Phe Tyr Phe Cys 
        195                 200                 205             


Phe Ile Ser Leu Ser Thr Ile Gly Leu Gly Asp Tyr Val Pro Gly Glu 
    210                 215                 220                 


Ala Pro Gly Gln Pro Tyr Arg Ala Leu Tyr Lys Val Leu Val Thr Val 
225                 230                 235                 240 


Tyr Leu Phe Leu Gly Leu Val Ala Met Val Leu Val Leu Gln Thr Phe 
                245                 250                 255     


Arg His Val Ser Asp Leu His Gly Leu Thr Glu Leu Ile Leu Leu Pro 
            260                 265                 270         


Pro Pro Cys Pro Ala Ser Phe Asn Ala Asp Glu Asp Asp Arg Val Asp 
        275                 280                 285             


Ile Leu Gly Pro Gln Pro Glu Ser His Gln Gln Leu Ser Ala Ser Ser 
    290                 295                 300                 


His Thr Asp Tyr Ala Ser Ile Pro Arg 
305                 310             


<210>  3140
<211>  544
<212>  PRT
<213>  Homo sapiens

<400>  3140

Met Ala Ser Glu Glu Leu Tyr Glu Val Glu Arg Ile Val Asp Lys Arg 
1               5                   10                  15      


Lys Asn Lys Lys Gly Lys Thr Glu Tyr Leu Val Arg Trp Lys Gly Tyr 
            20                  25                  30          


Asp Ser Glu Asp Asp Thr Trp Glu Pro Glu Gln His Leu Val Asn Cys 
        35                  40                  45              


Glu Glu Tyr Ile His Asp Phe Asn Arg Arg His Thr Glu Lys Gln Lys 
    50                  55                  60                  


Glu Ser Thr Leu Thr Arg Thr Asn Arg Thr Ser Pro Asn Asn Ala Arg 
65                  70                  75                  80  


Lys Gln Ile Ser Arg Ser Thr Asn Ser Asn Phe Ser Lys Thr Ser Pro 
                85                  90                  95      


Lys Ala Leu Val Ile Gly Lys Asp His Glu Ser Lys Asn Ser Gln Leu 
            100                 105                 110         


Phe Ala Ala Ser Gln Lys Phe Arg Lys Asn Thr Ala Pro Ser Leu Ser 
        115                 120                 125             


Ser Arg Lys Asn Met Asp Leu Ala Lys Ser Gly Ile Lys Ile Leu Val 
    130                 135                 140                 


Pro Lys Ser Pro Val Lys Ser Arg Thr Ala Val Asp Gly Phe Gln Ser 
145                 150                 155                 160 


Glu Ser Pro Glu Lys Leu Asp Pro Val Glu Gln Gly Gln Glu Asp Thr 
                165                 170                 175     


Val Ala Pro Glu Val Ala Ala Glu Lys Pro Val Gly Ala Leu Leu Gly 
            180                 185                 190         


Pro Gly Ala Glu Arg Ala Arg Met Gly Ser Arg Pro Arg Ile His Pro 
        195                 200                 205             


Leu Val Pro Gln Val Pro Gly Pro Val Thr Ala Ala Met Ala Thr Gly 
    210                 215                 220                 


Leu Ala Val Asn Gly Lys Gly Thr Ser Pro Phe Met Asp Ala Leu Thr 
225                 230                 235                 240 


Ala Asn Gly Thr Thr Asn Ile Gln Thr Ser Val Thr Gly Val Thr Ala 
                245                 250                 255     


Ser Lys Arg Lys Phe Ile Asp Asp Arg Arg Asp Gln Pro Phe Asp Lys 
            260                 265                 270         


Arg Leu Arg Phe Ser Val Arg Gln Thr Glu Ser Ala Tyr Arg Tyr Arg 
        275                 280                 285             


Asp Ile Val Val Arg Lys Gln Asp Gly Phe Thr His Ile Leu Leu Ser 
    290                 295                 300                 


Thr Lys Ser Ser Glu Asn Asn Ser Leu Asn Pro Glu Val Met Arg Glu 
305                 310                 315                 320 


Val Gln Ser Ala Leu Ser Thr Ala Ala Ala Asp Asp Ser Lys Leu Val 
                325                 330                 335     


Leu Leu Ser Ala Val Gly Ser Val Phe Cys Cys Gly Leu Asp Phe Ile 
            340                 345                 350         


Tyr Phe Ile Arg Arg Leu Thr Asp Asp Arg Lys Arg Glu Ser Thr Lys 
        355                 360                 365             


Met Ala Glu Ala Ile Arg Asn Phe Val Asn Thr Phe Ile Gln Phe Lys 
    370                 375                 380                 


Lys Pro Ile Ile Val Ala Val Asn Gly Pro Ala Ile Gly Leu Gly Ala 
385                 390                 395                 400 


Ser Ile Leu Pro Leu Cys Asp Val Val Trp Ala Asn Glu Lys Ala Trp 
                405                 410                 415     


Phe Gln Thr Pro Tyr Thr Thr Phe Gly Gln Ser Pro Asp Gly Cys Ser 
            420                 425                 430         


Thr Val Met Phe Pro Lys Ile Met Gly Gly Ala Ser Ala Asn Glu Met 
        435                 440                 445             


Leu Leu Ser Gly Arg Lys Leu Thr Ala Gln Glu Ala Cys Gly Lys Gly 
    450                 455                 460                 


Leu Val Ser Gln Val Phe Trp Pro Gly Thr Phe Thr Gln Glu Val Met 
465                 470                 475                 480 


Val Arg Ile Lys Glu Leu Ala Ser Cys Asn Pro Val Val Leu Glu Glu 
                485                 490                 495     


Ser Lys Ala Leu Val Arg Cys Asn Met Lys Met Glu Leu Glu Gln Ala 
            500                 505                 510         


Asn Glu Arg Glu Cys Glu Val Leu Lys Lys Ile Trp Gly Ser Ala Gln 
        515                 520                 525             


Gly Met Asp Ser Met Leu Lys Tyr Leu Gln Arg Lys Ile Asp Glu Phe 
    530                 535                 540                 


<210>  3141
<211>  775
<212>  PRT
<213>  Homo sapiens

<400>  3141

Met Glu Pro Pro Tyr Ser Leu Thr Ala His Tyr Asp Glu Phe Gln Glu 
1               5                   10                  15      


Val Lys Tyr Val Ser Arg Cys Gly Ala Gly Gly Ala Arg Gly Ala Ser 
            20                  25                  30          


Leu Pro Pro Gly Phe Pro Leu Gly Ala Ala Arg Ser Ala Thr Gly Ala 
        35                  40                  45              


Arg Ser Gly Leu Pro Arg Trp Asn Arg Arg Glu Val Cys Leu Leu Ser 
    50                  55                  60                  


Gly Leu Val Phe Ala Ala Gly Leu Cys Ala Ile Leu Ala Ala Met Leu 
65                  70                  75                  80  


Ala Leu Lys Tyr Leu Gly Pro Val Ala Ala Gly Gly Gly Ala Cys Pro 
                85                  90                  95      


Glu Gly Cys Pro Glu Arg Lys Ala Phe Ala Arg Ala Ala Arg Phe Leu 
            100                 105                 110         


Ala Ala Asn Leu Asp Ala Ser Ile Asp Pro Cys Gln Asp Phe Tyr Ser 
        115                 120                 125             


Phe Ala Cys Gly Gly Trp Leu Arg Arg His Ala Ile Pro Asp Asp Lys 
    130                 135                 140                 


Leu Thr Tyr Gly Thr Ile Ala Ala Ile Gly Glu Gln Asn Glu Glu Arg 
145                 150                 155                 160 


Leu Arg Arg Leu Leu Ala Arg Pro Gly Gly Gly Pro Gly Gly Ala Ala 
                165                 170                 175     


Gln Arg Lys Val Arg Ala Phe Phe Arg Ser Cys Leu Asp Met Arg Glu 
            180                 185                 190         


Ile Glu Arg Leu Gly Pro Arg Pro Met Leu Glu Val Ile Glu Asp Cys 
        195                 200                 205             


Gly Gly Trp Asp Leu Gly Gly Ala Glu Glu Arg Pro Gly Val Ala Ala 
    210                 215                 220                 


Arg Trp Asp Leu Asn Arg Leu Leu Tyr Lys Ala Gln Gly Val Tyr Ser 
225                 230                 235                 240 


Ala Ala Ala Leu Phe Ser Leu Thr Val Ser Leu Asp Asp Arg Asn Ser 
                245                 250                 255     


Ser Arg Tyr Val Ile Arg Ile Asp Gln Asp Gly Leu Thr Leu Pro Glu 
            260                 265                 270         


Arg Thr Leu Tyr Leu Ala Gln Asp Glu Asp Ser Glu Lys Ile Leu Ala 
        275                 280                 285             


Ala Tyr Arg Val Phe Met Glu Arg Val Leu Ser Leu Leu Gly Ala Asp 
    290                 295                 300                 


Ala Val Glu Gln Lys Ala Gln Glu Ile Leu Gln Val Glu Gln Gln Leu 
305                 310                 315                 320 


Ala Asn Ile Thr Val Ser Glu His Asp Asp Leu Arg Arg Asp Val Ser 
                325                 330                 335     


Ser Met Tyr Asn Lys Val Thr Leu Gly Gln Leu Gln Lys Ile Thr Pro 
            340                 345                 350         


His Leu Arg Trp Lys Trp Leu Leu Asp Gln Ile Phe Gln Glu Asp Phe 
        355                 360                 365             


Ser Glu Glu Glu Glu Val Val Leu Leu Ala Thr Asp Tyr Met Gln Gln 
    370                 375                 380                 


Val Ser Gln Leu Ile Arg Ser Thr Pro His Arg Val Leu His Asn Tyr 
385                 390                 395                 400 


Leu Val Trp Arg Val Val Val Val Leu Ser Glu His Leu Ser Pro Pro 
                405                 410                 415     


Phe Arg Glu Ala Leu His Glu Leu Ala Gln Glu Met Glu Gly Ser Asp 
            420                 425                 430         


Lys Pro Gln Glu Leu Ala Arg Val Cys Leu Gly Gln Ala Asn Arg His 
        435                 440                 445             


Phe Gly Met Ala Leu Gly Ala Leu Phe Val His Glu His Phe Ser Ala 
    450                 455                 460                 


Ala Ser Lys Ala Lys Val Gln Gln Leu Val Glu Asp Ile Lys Tyr Ile 
465                 470                 475                 480 


Leu Gly Gln Arg Leu Glu Glu Leu Asp Trp Met Asp Ala Glu Thr Arg 
                485                 490                 495     


Ala Ala Ala Arg Ala Lys Leu Gln Tyr Met Met Val Met Val Gly Tyr 
            500                 505                 510         


Pro Asp Phe Leu Leu Lys Pro Asp Ala Val Asp Lys Glu Tyr Glu Phe 
        515                 520                 525             


Glu Val His Glu Lys Thr Tyr Phe Lys Asn Ile Leu Asn Ser Ile Arg 
    530                 535                 540                 


Phe Ser Ile Gln Leu Ser Val Lys Lys Ile Arg Gln Glu Val Asp Lys 
545                 550                 555                 560 


Ser Thr Trp Leu Leu Pro Pro Gln Ala Leu Asn Ala Tyr Tyr Leu Pro 
                565                 570                 575     


Asn Lys Asn Gln Met Val Phe Pro Ala Gly Ile Leu Gln Pro Thr Leu 
            580                 585                 590         


Tyr Asp Pro Asp Phe Pro Gln Ser Leu Asn Tyr Gly Gly Ile Gly Thr 
        595                 600                 605             


Ile Ile Gly His Glu Leu Thr His Gly Tyr Asp Asp Trp Gly Gly Gln 
    610                 615                 620                 


Tyr Asp Arg Ser Gly Asn Leu Leu His Trp Trp Thr Glu Ala Ser Tyr 
625                 630                 635                 640 


Ser Arg Phe Leu Arg Lys Ala Glu Cys Ile Val Arg Leu Tyr Asp Asn 
                645                 650                 655     


Phe Thr Val Tyr Asn Gln Arg Val Asn Gly Lys His Thr Leu Gly Glu 
            660                 665                 670         


Asn Ile Ala Asp Met Gly Gly Leu Lys Leu Ala Tyr His Ala Tyr Gln 
        675                 680                 685             


Lys Trp Val Arg Glu His Gly Pro Glu His Pro Leu Pro Arg Leu Lys 
    690                 695                 700                 


Tyr Thr His Asp Gln Leu Phe Phe Ile Ala Phe Ala Gln Asn Trp Cys 
705                 710                 715                 720 


Ile Lys Arg Arg Ser Gln Ser Ile Tyr Leu Gln Val Leu Thr Asp Lys 
                725                 730                 735     


His Ala Pro Glu His Tyr Arg Val Leu Gly Ser Val Ser Gln Phe Glu 
            740                 745                 750         


Glu Phe Gly Arg Ala Phe His Cys Pro Lys Asp Ser Pro Met Asn Pro 
        755                 760                 765             


Ala His Lys Cys Ser Val Trp 
    770                 775 


<210>  3142
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  3142

Met Ser Ser Ser Asn Val Glu Val Phe Ile Pro Val Ser Gln Gly Asn 
1               5                   10                  15      


Thr Asn Gly Phe Pro Ala Thr Ala Ser Asn Asp Leu Lys Ala Phe Thr 
            20                  25                  30          


Glu Gly Ala Val Leu Ser Phe His Asn Ile Cys Tyr Arg Val Lys Leu 
        35                  40                  45              


Lys Ser Gly Phe Leu Pro Cys Arg Lys Pro Val Glu Lys Glu Ile Leu 
    50                  55                  60                  


Ser Asn Ile Asn Gly Ile Met Lys Pro Gly Leu Asn Ala Ile Leu Gly 
65                  70                  75                  80  


Pro Thr Gly Gly Gly Lys Ser Ser Leu Leu Asp Val Leu Ala Ala Arg 
                85                  90                  95      


Lys Asp Pro Ser Gly Leu Ser Gly Asp Val Leu Ile Asn Gly Ala Pro 
            100                 105                 110         


Arg Pro Ala Asn Phe Lys Cys Asn Ser Gly Tyr Val Val Gln Asp Asp 
        115                 120                 125             


Val Val Met Gly Thr Leu Thr Val Arg Glu Asn Leu Gln Phe Ser Ala 
    130                 135                 140                 


Ala Leu Arg Leu Ala Thr Thr Met Thr Asn His Glu Lys Asn Glu Arg 
145                 150                 155                 160 


Ile Asn Arg Val Ile Gln Glu Leu Gly Leu Asp Lys Val Ala Asp Ser 
                165                 170                 175     


Lys Val Gly Thr Gln Phe Ile Arg Gly Val Ser Gly Gly Glu Arg Lys 
            180                 185                 190         


Arg Thr Ser Ile Gly Met Glu Leu Ile Thr Asp Pro Ser Ile Leu Phe 
        195                 200                 205             


Leu Asp Glu Pro Thr Thr Gly Leu Asp Ser Ser Thr Ala Asn Ala Val 
    210                 215                 220                 


Leu Leu Leu Leu Lys Arg Met Ser Lys Gln Gly Arg Thr Ile Ile Phe 
225                 230                 235                 240 


Ser Ile His Gln Pro Arg Tyr Ser Ile Phe Lys Leu Phe Asp Ser Leu 
                245                 250                 255     


Thr Leu Leu Ala Ser Gly Arg Leu Met Phe His Gly Pro Ala Gln Glu 
            260                 265                 270         


Ala Leu Gly Tyr Phe Glu Ser Ala Gly Tyr His Cys Glu Ala Tyr Asn 
        275                 280                 285             


Asn Pro Ala Asp Phe Phe Leu Asp Ile Ile Asn Gly Asp Ser Thr Ala 
    290                 295                 300                 


Val Ala Leu Asn Arg Glu Glu Asp Phe Lys Ala Thr Glu Ile Ile Glu 
305                 310                 315                 320 


Pro Ser Lys Gln Asp Lys Pro Leu Ile Glu Lys Leu Ala Glu Ile Tyr 
                325                 330                 335     


Val Asn Ser Ser Phe Tyr Lys Glu Thr Lys Ala Glu Leu His Gln Leu 
            340                 345                 350         


Ser Gly Gly Glu Lys Lys Lys Lys Ile Thr Val Phe Lys Glu Ile Ser 
        355                 360                 365             


Tyr Thr Thr Ser Phe Cys His Gln Leu Arg Trp Val Ser Lys Arg Ser 
    370                 375                 380                 


Phe Lys Asn Leu Leu Gly Asn Pro Gln Ala Ser Ile Ala Gln Ile Ile 
385                 390                 395                 400 


Val Thr Val Val Leu Gly Leu Val Ile Gly Ala Ile Tyr Phe Gly Leu 
                405                 410                 415     


Lys Asn Asp Ser Thr Gly Ile Gln Asn Arg Ala Gly Val Leu Phe Phe 
            420                 425                 430         


Leu Thr Thr Asn Gln Cys Phe Ser Ser Val Ser Ala Val Glu Leu Phe 
        435                 440                 445             


Val Val Glu Lys Lys Leu Phe Ile His Glu Tyr Ile Ser Gly Tyr Tyr 
    450                 455                 460                 


Arg Val Ser Ser Tyr Phe Leu Gly Lys Leu Leu Ser Asp Leu Leu Pro 
465                 470                 475                 480 


Met Arg Met Leu Pro Ser Ile Ile Phe Thr Cys Ile Val Tyr Phe Met 
                485                 490                 495     


Leu Gly Leu Lys Pro Lys Ala Asp Ala Phe Phe Val Met Met Phe Thr 
            500                 505                 510         


Leu Met Met Val Ala Tyr Ser Ala Ser Ser Met Ala Leu Ala Ile Ala 
        515                 520                 525             


Ala Gly Gln Ser Val Val Ser Val Ala Thr Leu Leu Met Thr Ile Cys 
    530                 535                 540                 


Phe Val Phe Met Met Ile Phe Ser Gly Leu Leu Val Asn Leu Thr Thr 
545                 550                 555                 560 


Ile Ala Ser Trp Leu Ser Trp Leu Gln Tyr Phe Ser Ile Pro Arg Tyr 
                565                 570                 575     


Gly Phe Thr Ala Leu Gln His Asn Glu Phe Leu Gly Gln Asn Phe Cys 
            580                 585                 590         


Pro Gly Leu Asn Ala Thr Gly Asn Asn Pro Cys Asn Tyr Ala Thr Cys 
        595                 600                 605             


Thr Gly Glu Glu Tyr Leu Val Lys Gln Gly Ile Asp Leu Ser Pro Trp 
    610                 615                 620                 


Gly Leu Trp Lys Asn His Val Ala Leu Ala Cys Met Ile Val Ile Phe 
625                 630                 635                 640 


Leu Thr Ile Ala Tyr Leu Lys Leu Leu Phe Leu Lys Lys Tyr Ser 
                645                 650                 655 


<210>  3143
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  3143

Met Ala Trp Arg Ala Leu His Pro Leu Leu Leu Leu Leu Leu Leu Phe 
1               5                   10                  15      


Pro Gly Ser Gln Ala Gln Ser Lys Ala Gln Val Leu Gln Ser Val Ala 
            20                  25                  30          


Gly Gln Thr Leu Thr Val Arg Cys Gln Tyr Pro Pro Thr Gly Ser Leu 
        35                  40                  45              


Tyr Glu Lys Lys Gly Trp Cys Lys Glu Ala Ser Ala Leu Val Cys Ile 
    50                  55                  60                  


Arg Leu Val Thr Ser Ser Lys Pro Arg Thr Met Ala Trp Thr Ser Arg 
65                  70                  75                  80  


Phe Thr Ile Trp Asp Asp Pro Asp Ala Gly Phe Phe Thr Val Thr Met 
                85                  90                  95      


Thr Asp Leu Arg Glu Glu Asp Ser Gly His Tyr Trp Cys Arg Ile Tyr 
            100                 105                 110         


Arg Pro Ser Asp Asn Ser Val Ser Lys Ser Val Arg Phe Tyr Leu Val 
        115                 120                 125             


Val Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp 
    130                 135                 140                 


Leu Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala 
145                 150                 155                 160 


Gly Ala Arg Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser 
                165                 170                 175     


Gln Pro Gln Asn Ser Thr Leu Arg Pro Gly Pro Ala Ala Pro Ile Ala 
            180                 185                 190         


Leu Val Pro Val Phe Cys Gly Leu Leu Val Ala Lys Ser Leu Val Leu 
        195                 200                 205             


Ser Ala Leu Leu Val Trp Trp Gly Asp Ile Trp Trp Lys Thr Met Met 
    210                 215                 220                 


Glu Leu Arg Ser Leu Asp Thr Gln Lys Ala Thr Cys His Leu Gln Gln 
225                 230                 235                 240 


Val Thr Asp Leu Pro Trp Thr Ser Val Ser Ser Pro Val Glu Arg Glu 
                245                 250                 255     


Ile Leu Tyr His Thr Val Ala Arg Thr Lys Ile Ser Asp Asp Asp Asp 
            260                 265                 270         


Glu His Thr Leu 
        275     


<210>  3144
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  3144

Met Ser Ser Thr Leu Pro Ala Leu Leu Cys Val Gly Leu Cys Leu Ser 
1               5                   10                  15      


Gln Arg Ile Ser Ala Gln Gln Gln Thr Leu Pro Lys Pro Phe Ile Trp 
            20                  25                  30          


Ala Glu Pro His Phe Met Val Pro Lys Glu Lys Gln Val Thr Ile Cys 
        35                  40                  45              


Cys Gln Gly Asn Tyr Gly Ala Val Glu Tyr Gln Leu His Phe Glu Gly 
    50                  55                  60                  


Ser Leu Phe Ala Val Asp Arg Pro Lys Pro Pro Glu Arg Ile Asn Lys 
65                  70                  75                  80  


Val Gln Phe Tyr Ile Pro Asp Met Asn Ser Arg Met Ala Gly Gln Tyr 
                85                  90                  95      


Ser Cys Ile Tyr Arg Val Gly Glu Leu Trp Ser Glu Pro Ser Asn Leu 
            100                 105                 110         


Leu Asp Leu Val Val Thr Glu Met Tyr Asp Thr Pro Thr Leu Ser Val 
        115                 120                 125             


His Pro Gly Pro Glu Val Ile Ser Gly Glu Lys Val Thr Phe Tyr Cys 
    130                 135                 140                 


Arg Leu Asp Thr Ala Thr Ser Met Phe Leu Leu Leu Lys Glu Gly Arg 
145                 150                 155                 160 


Ser Ser His Val Gln Arg Gly Tyr Gly Lys Val Gln Ala Glu Phe Pro 
                165                 170                 175     


Leu Gly Pro Val Thr Thr Ala His Arg Gly Thr Tyr Arg Cys Phe Gly 
            180                 185                 190         


Ser Tyr Asn Asn His Ala Trp Ser Phe Pro Ser Glu Pro Val Lys Leu 
        195                 200                 205             


Leu Val Thr Gly Asp Ile Glu Asn Thr Ser Leu Ala Pro Glu Asp Pro 
    210                 215                 220                 


Thr Phe Pro Ala Asp Thr Trp Gly Thr Tyr Leu Leu Thr Thr Glu Thr 
225                 230                 235                 240 


Gly Leu Gln Lys Asp His Ala Leu Trp Asp His Thr Ala Gln Asn Leu 
                245                 250                 255     


Leu Arg Met Gly Leu Ala Phe Leu Val Leu Val Ala Leu Val Trp Phe 
            260                 265                 270         


Leu Val Glu Asp Trp Leu Ser Arg Lys Arg Thr Arg Glu Arg Ala Ser 
        275                 280                 285             


Arg Ala Ser Thr Trp Glu Gly Arg Arg Arg Leu Asn Thr Gln Thr Leu 
    290                 295                 300                 


<210>  3145
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  3145

Met Lys Lys Met Asn His Lys Ser Thr Asp Ser Pro Lys Ala Pro Gln 
1               5                   10                  15      


Leu Arg Gly Gly Val Phe Asp Ile Val Phe Ala Thr Asn Ser Thr Gln 
            20                  25                  30          


Val Ile Lys Met Ile Leu Asn Ser Ser Thr Glu Asp Gly Ile Lys Arg 
        35                  40                  45              


Ile Gln Asp Asp Cys Pro Lys Ala Gly Arg His Asn Tyr Ile Phe Val 
    50                  55                  60                  


Met Ile Pro Thr Leu Tyr Ser Ile Ile Phe Val Val Gly Ile Phe Gly 
65                  70                  75                  80  


Asn Ser Leu Val Val Ile Val Ile Tyr Phe Tyr Met Lys Leu Lys Thr 
                85                  90                  95      


Val Ala Ser Val Phe Leu Leu Asn Leu Ala Leu Ala Asp Leu Cys Phe 
            100                 105                 110         


Leu Leu Thr Leu Pro Leu Trp Ala Val Tyr Thr Ala Met Glu Tyr Arg 
        115                 120                 125             


Trp Pro Phe Gly Asn Tyr Leu Cys Lys Ile Ala Ser Ala Ser Val Ser 
    130                 135                 140                 


Phe Asn Leu Tyr Ala Ser Val Phe Leu Leu Thr Cys Leu Ser Ile Asp 
145                 150                 155                 160 


Arg Tyr Leu Ala Ile Val His Pro Met Lys Ser Arg Leu Arg Arg Thr 
                165                 170                 175     


Met Leu Val Ala Lys Val Thr Cys Ile Ile Ile Trp Leu Leu Ala Gly 
            180                 185                 190         


Leu Ala Ser Leu Pro Ala Ile Ile His Arg Asn Val Phe Phe Ile Glu 
        195                 200                 205             


Asn Thr Asn Ile Thr Val Cys Ala Phe His Tyr Glu Ser Gln Asn Ser 
    210                 215                 220                 


Thr Leu Pro Ile Gly Leu Gly Leu Thr Lys Asn Ile Leu Gly Phe Leu 
225                 230                 235                 240 


Phe Pro Phe Leu Ile Ile Leu Thr Ser Tyr Thr Leu Ile Trp Lys Ala 
                245                 250                 255     


Leu Lys Lys Ala Tyr Glu Ile Gln Lys Asn Lys Pro Arg Asn Asp Asp 
            260                 265                 270         


Ile Phe Lys Ile Ile Met Ala Ile Val Leu Phe Phe Phe Phe Ser Trp 
        275                 280                 285             


Ile Pro His Gln Ile Phe Thr Phe Leu Asp Val Leu Ile Gln Leu Gly 
    290                 295                 300                 


Ile Ile Arg Asp Cys Arg Ile Ala Asp Ile Val Asp Thr Ala Met Pro 
305                 310                 315                 320 


Ile Thr Ile Cys Ile Ala Tyr Phe Asn Asn Cys Leu Asn Pro Leu Phe 
                325                 330                 335     


Tyr Gly Phe Leu Gly Lys Lys Phe Lys Arg Tyr Phe Leu Gln Leu Leu 
            340                 345                 350         


Lys Tyr Ile Pro Pro Lys Ala Lys Ser His Ser Asn Leu Ser Thr Lys 
        355                 360                 365             


Met Ser Thr Leu Ser Tyr Arg Pro Ser Asp Asn Val Ser Ser Ser Thr 
    370                 375                 380                 


Lys Lys Pro Ala Pro Cys Phe Glu Val Glu 
385                 390                 


<210>  3146
<211>  1116
<212>  PRT
<213>  Homo sapiens

<400>  3146

Met Glu Arg Ala Ile Ser Pro Gly Leu Leu Val Arg Ala Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Gly Leu Ala Ala Arg Thr Val Ala Ala Gly Arg 
            20                  25                  30          


Ala Arg Gly Leu Pro Ala Pro Thr Ala Glu Ala Ala Phe Gly Leu Gly 
        35                  40                  45              


Ala Ala Ala Ala Pro Thr Ser Ala Thr Arg Val Pro Ala Ala Gly Ala 
    50                  55                  60                  


Val Ala Ala Ala Glu Val Thr Val Glu Asp Ala Glu Ala Leu Pro Ala 
65                  70                  75                  80  


Ala Ala Gly Glu Gln Glu Pro Arg Gly Pro Glu Pro Asp Asp Glu Thr 
                85                  90                  95      


Glu Leu Arg Pro Arg Gly Arg Ser Leu Val Ile Ile Ser Thr Leu Asp 
            100                 105                 110         


Gly Arg Ile Ala Ala Leu Asp Pro Glu Asn His Gly Lys Lys Gln Trp 
        115                 120                 125             


Asp Leu Asp Val Gly Ser Gly Ser Leu Val Ser Ser Ser Leu Ser Lys 
    130                 135                 140                 


Pro Glu Val Phe Gly Asn Lys Met Ile Ile Pro Ser Leu Asp Gly Ala 
145                 150                 155                 160 


Leu Phe Gln Trp Asp Gln Asp Arg Glu Ser Met Glu Thr Val Pro Phe 
                165                 170                 175     


Thr Val Glu Ser Leu Leu Glu Ser Ser Tyr Lys Phe Gly Asp Asp Val 
            180                 185                 190         


Val Leu Val Gly Gly Lys Ser Leu Thr Thr Tyr Gly Leu Ser Ala Tyr 
        195                 200                 205             


Ser Gly Lys Val Arg Tyr Ile Cys Ser Ala Leu Gly Cys Arg Gln Trp 
    210                 215                 220                 


Asp Ser Asp Glu Met Glu Gln Glu Glu Asp Ile Leu Leu Leu Gln Arg 
225                 230                 235                 240 


Thr Gln Lys Thr Val Arg Ala Val Gly Pro Arg Ser Gly Asn Glu Lys 
                245                 250                 255     


Trp Asn Phe Ser Val Gly His Phe Glu Leu Arg Tyr Ile Pro Asp Met 
            260                 265                 270         


Glu Thr Arg Ala Gly Phe Ile Glu Ser Thr Phe Lys Pro Asn Glu Asn 
        275                 280                 285             


Thr Glu Glu Ser Lys Ile Ile Ser Asp Val Glu Glu Gln Glu Ala Ala 
    290                 295                 300                 


Ile Met Asp Ile Val Ile Lys Val Ser Val Ala Asp Trp Lys Val Met 
305                 310                 315                 320 


Ala Phe Ser Lys Lys Gly Gly His Leu Glu Trp Glu Tyr Gln Phe Cys 
                325                 330                 335     


Thr Pro Ile Ala Ser Ala Trp Leu Leu Lys Asp Gly Lys Val Ile Pro 
            340                 345                 350         


Ile Ser Leu Phe Asp Asp Thr Ser Tyr Thr Ser Asn Asp Asp Val Leu 
        355                 360                 365             


Glu Asp Glu Glu Asp Ile Val Glu Ala Ala Arg Gly Ala Thr Glu Asn 
    370                 375                 380                 


Ser Val Tyr Leu Gly Met Tyr Arg Gly Gln Leu Tyr Leu Gln Ser Ser 
385                 390                 395                 400 


Val Arg Ile Ser Glu Lys Phe Pro Ser Ser Pro Lys Ala Leu Glu Ser 
                405                 410                 415     


Val Thr Asn Glu Asn Ala Ile Ile Pro Leu Pro Thr Ile Lys Trp Lys 
            420                 425                 430         


Pro Leu Ile His Ser Pro Ser Arg Thr Pro Val Leu Val Gly Ser Asp 
        435                 440                 445             


Glu Phe Asp Lys Cys Leu Ser Asn Asp Lys Phe Ser His Glu Glu Tyr 
    450                 455                 460                 


Ser Asn Gly Ala Leu Ser Ile Leu Gln Tyr Pro Tyr Asp Asn Gly Tyr 
465                 470                 475                 480 


Tyr Leu Pro Tyr Tyr Lys Arg Glu Arg Asn Lys Arg Ser Thr Gln Ile 
                485                 490                 495     


Thr Val Arg Phe Leu Asp Asn Pro His Tyr Asn Lys Asn Ile Arg Lys 
            500                 505                 510         


Lys Asp Pro Val Leu Leu Leu His Trp Trp Lys Glu Ile Val Ala Thr 
        515                 520                 525             


Ile Leu Phe Cys Ile Ile Ala Thr Thr Phe Ile Val Arg Arg Leu Phe 
    530                 535                 540                 


His Pro His Pro His Arg Gln Arg Lys Glu Ser Glu Thr Gln Cys Gln 
545                 550                 555                 560 


Thr Glu Asn Lys Tyr Asp Ser Val Ser Gly Glu Ala Asn Asp Ser Ser 
                565                 570                 575     


Trp Asn Asp Ile Lys Asn Ser Gly Tyr Ile Ser Arg Tyr Leu Thr Asp 
            580                 585                 590         


Phe Glu Pro Ile Gln Cys Leu Gly Arg Gly Gly Phe Gly Val Val Phe 
        595                 600                 605             


Glu Ala Lys Asn Lys Val Asp Asp Cys Asn Tyr Ala Ile Lys Arg Ile 
    610                 615                 620                 


Arg Leu Pro Asn Arg Glu Leu Ala Arg Glu Lys Val Met Arg Glu Val 
625                 630                 635                 640 


Lys Ala Leu Ala Lys Leu Glu His Pro Gly Ile Val Arg Tyr Phe Asn 
                645                 650                 655     


Ala Trp Leu Glu Ala Pro Pro Glu Lys Trp Gln Glu Lys Met Asp Glu 
            660                 665                 670         


Ile Trp Leu Lys Asp Glu Ser Thr Asp Trp Pro Leu Ser Ser Pro Ser 
        675                 680                 685             


Pro Met Asp Ala Pro Ser Val Lys Ile Arg Arg Met Asp Pro Phe Ala 
    690                 695                 700                 


Thr Lys Glu His Ile Glu Ile Ile Ala Pro Ser Pro Gln Arg Ser Arg 
705                 710                 715                 720 


Ser Phe Ser Val Gly Ile Ser Cys Asp Gln Thr Ser Ser Ser Glu Ser 
                725                 730                 735     


Gln Phe Ser Pro Leu Glu Phe Ser Gly Met Asp His Glu Asp Ile Ser 
            740                 745                 750         


Glu Ser Val Asp Ala Ala Tyr Asn Leu Gln Asp Ser Cys Leu Thr Asp 
        755                 760                 765             


Cys Asp Val Glu Asp Gly Thr Met Asp Gly Asn Asp Glu Gly His Ser 
    770                 775                 780                 


Phe Glu Leu Cys Pro Ser Glu Ala Ser Pro Tyr Val Arg Ser Arg Glu 
785                 790                 795                 800 


Arg Thr Ser Ser Ser Ile Val Phe Glu Asp Ser Gly Cys Asp Asn Ala 
                805                 810                 815     


Ser Ser Lys Glu Glu Pro Lys Thr Asn Arg Leu His Ile Gly Asn His 
            820                 825                 830         


Cys Ala Asn Lys Leu Thr Ala Phe Lys Pro Thr Ser Ser Lys Ser Ser 
        835                 840                 845             


Ser Glu Ala Thr Leu Ser Ile Ser Pro Pro Arg Pro Thr Thr Leu Ser 
    850                 855                 860                 


Leu Asp Leu Thr Lys Asn Thr Thr Glu Lys Leu Gln Pro Ser Ser Pro 
865                 870                 875                 880 


Lys Val Tyr Leu Tyr Ile Gln Met Gln Leu Cys Arg Lys Glu Asn Leu 
                885                 890                 895     


Lys Asp Trp Met Asn Gly Arg Cys Thr Ile Glu Glu Arg Glu Arg Ser 
            900                 905                 910         


Val Cys Leu His Ile Phe Leu Gln Ile Ala Glu Ala Val Glu Phe Leu 
        915                 920                 925             


His Ser Lys Gly Leu Met His Arg Asp Leu Lys Pro Ser Asn Ile Phe 
    930                 935                 940                 


Phe Thr Met Asp Asp Val Val Lys Val Gly Asp Phe Gly Leu Val Thr 
945                 950                 955                 960 


Ala Met Asp Gln Asp Glu Glu Glu Gln Thr Val Leu Thr Pro Met Pro 
                965                 970                 975     


Ala Tyr Ala Arg His Thr Gly Gln Val Gly Thr Lys Leu Tyr Met Ser 
            980                 985                 990         


Pro Glu Gln Ile His Gly Asn Ser  Tyr Ser His Lys Val  Asp Ile Phe 
        995                 1000                 1005             


Ser Leu  Gly Leu Ile Leu Phe  Glu Leu Leu Tyr Pro  Phe Ser Thr 
    1010                 1015                 1020             


Gln Met  Glu Arg Val Arg Thr  Leu Thr Asp Val Arg  Asn Leu Lys 
    1025                 1030                 1035             


Phe Pro  Pro Leu Phe Thr Gln  Lys Tyr Pro Cys Glu  Tyr Val Met 
    1040                 1045                 1050             


Val Gln  Asp Met Leu Ser Pro  Ser Pro Met Glu Arg  Pro Glu Ala 
    1055                 1060                 1065             


Ile Asn  Ile Ile Glu Asn Ala  Val Phe Glu Asp Leu  Asp Phe Pro 
    1070                 1075                 1080             


Gly Lys  Thr Val Leu Arg Gln  Arg Ser Arg Ser Leu  Ser Ser Ser 
    1085                 1090                 1095             


Gly Thr  Lys His Ser Arg Gln  Ser Asn Asn Ser His  Ser Pro Leu 
    1100                 1105                 1110             


Pro Ser  Asn 
    1115     


<210>  3147
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  3147

Met Ala Pro Asp Pro Trp Phe Ser Thr Tyr Asp Ser Thr Cys Gln Ile 
1               5                   10                  15      


Ala Gln Glu Ile Ala Glu Lys Ile Gln Gln Arg Asn Gln Tyr Glu Arg 
            20                  25                  30          


Lys Gly Glu Lys Ala Pro Lys Leu Thr Val Thr Ile Arg Ala Leu Leu 
        35                  40                  45              


Gln Asn Leu Lys Glu Lys Ile Ala Leu Leu Lys Asp Leu Leu Leu Arg 
    50                  55                  60                  


Ala Val Ser Thr His Gln Ile Thr Gln Leu Glu Gly Asp Arg Arg Gln 
65                  70                  75                  80  


Asn Leu Leu Asp Asp Leu Val Thr Arg Glu Arg Leu Leu Leu Ala Ser 
                85                  90                  95      


Phe Lys Asn Glu Gly Ala Glu Pro Asp Leu Ile Arg Ser Ser Leu Met 
            100                 105                 110         


Ser Glu Glu Ala Lys Arg Gly Ala Pro Asn Pro Trp Leu Phe Glu Glu 
        115                 120                 125             


Pro Glu Glu Thr Arg Gly Leu Gly Phe Asp Glu Ile Arg Gln Gln Gln 
    130                 135                 140                 


Gln Lys Ile Ile Gln Glu Gln Asp Ala Gly Leu Asp Ala Leu Ser Ser 
145                 150                 155                 160 


Ile Ile Ser Arg Gln Lys Gln Met Gly Gln Glu Ile Gly Asn Glu Leu 
                165                 170                 175     


Asp Glu Gln Asn Glu Ile Ile Asp Asp Leu Ala Asn Leu Val Glu Asn 
            180                 185                 190         


Thr Asp Glu Lys Leu Arg Asn Glu Thr Arg Arg Val Asn Met Val Asp 
        195                 200                 205             


Arg Lys Ser Ala Ser Cys Gly Met Ile Met Val Ile Leu Leu Leu Leu 
    210                 215                 220                 


Val Ala Ile Val Val Val Ala Val Trp Pro Thr Asn 
225                 230                 235     


<210>  3148
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  3148

Met His His Gln Trp Leu Leu Leu Ala Ala Cys Phe Trp Val Ile Phe 
1               5                   10                  15      


Met Phe Met Val Ala Ser Lys Phe Ile Thr Leu Thr Phe Lys Asp Pro 
            20                  25                  30          


Asp Val Tyr Ser Ala Lys Gln Glu Phe Leu Phe Leu Thr Thr Met Pro 
        35                  40                  45              


Glu Val Arg Lys Leu Pro Glu Glu Lys His Ile Pro Glu Glu Leu Lys 
    50                  55                  60                  


Pro Thr Gly Lys Glu Leu Pro Asp Ser Gln Leu Val Gln Pro Leu Val 
65                  70                  75                  80  


Tyr Met Glu Arg Leu Glu Leu Ile Arg Asn Val Cys Arg Asp Asp Ala 
                85                  90                  95      


Leu Lys Asn Leu Ser His Thr Pro Val Ser Lys Phe Val Leu Asp Arg 
            100                 105                 110         


Ile Phe Val Cys Asp Lys His Lys Ile Leu Phe Cys Gln Thr Pro Lys 
        115                 120                 125             


Val Gly Asn Thr Gln Trp Lys Lys Val Leu Ile Val Leu Asn Gly Ala 
    130                 135                 140                 


Phe Ser Ser Ile Glu Glu Ile Pro Glu Asn Val Val His Asp His Glu 
145                 150                 155                 160 


Lys Asn Gly Leu Pro Arg Leu Ser Ser Phe Ser Asp Ala Glu Ile Gln 
                165                 170                 175     


Lys Arg Leu Lys Thr Tyr Phe Lys Phe Phe Ile Val Arg Asp Pro Phe 
            180                 185                 190         


Glu Arg Leu Ile Ser Ala Phe Lys Asp Lys Phe Val His Asn Pro Arg 
        195                 200                 205             


Phe Glu Pro Trp Tyr Arg His Glu Ile Ala Pro Gly Ile Ile Arg Lys 
    210                 215                 220                 


Tyr Arg Arg Asn Arg Thr Glu Thr Arg Gly Ile Gln Phe Glu Asp Phe 
225                 230                 235                 240 


Val Arg Tyr Leu Gly Asp Pro Asn His Arg Trp Leu Asp Leu Gln Phe 
                245                 250                 255     


Gly Asp His Ile Ile His Trp Val Thr Tyr Val Glu Leu Cys Ala Pro 
            260                 265                 270         


Cys Glu Ile Met Tyr Ser Val Ile Gly His His Glu Thr Leu Glu Asp 
        275                 280                 285             


Asp Ala Pro Tyr Ile Leu Lys Glu Ala Gly Ile Asp His Leu Val Ser 
    290                 295                 300                 


Tyr Pro Thr Ile Pro Pro Gly Ile Thr Val Tyr Asn Arg Thr Lys Val 
305                 310                 315                 320 


Glu His Tyr Phe Leu Gly Ile Ser Lys Arg Asp Ile Arg Arg Leu Tyr 
                325                 330                 335     


Ala Arg Phe Glu Gly Asp Phe Lys Leu Phe Gly Tyr Gln Lys Pro Asp 
            340                 345                 350         


Phe Leu Leu Asn 
        355     


<210>  3149
<211>  554
<212>  PRT
<213>  Homo sapiens

<400>  3149

Met Arg Arg Pro Leu Ser Lys Cys Gly Met Glu Pro Gly Gly Gly Asp 
1               5                   10                  15      


Ala Ser Leu Thr Leu His Gly Leu Gln Asn Arg Ser His Gly Lys Ile 
            20                  25                  30          


Lys Leu Arg Lys Arg Lys Ser Thr Leu Tyr Phe Asn Thr Gln Glu Lys 
        35                  40                  45              


Ser Ala Arg Arg Arg Gly Asp Leu Leu Gly Glu Asn Ile Tyr Leu Leu 
    50                  55                  60                  


Leu Phe Thr Ile Ala Leu Arg Ile Leu Asn Cys Phe Leu Val Gln Thr 
65                  70                  75                  80  


Ser Phe Val Pro Asp Glu Tyr Trp Gln Ser Leu Glu Val Ser His His 
                85                  90                  95      


Met Val Phe Asn Tyr Gly Tyr Leu Thr Trp Glu Trp Thr Glu Arg Leu 
            100                 105                 110         


Arg Ser Tyr Thr Tyr Pro Leu Ile Phe Ala Ser Ile Tyr Lys Ile Leu 
        115                 120                 125             


His Leu Leu Gly Lys Asp Ser Val Gln Leu Leu Ile Trp Ile Pro Arg 
    130                 135                 140                 


Leu Ala Gln Ala Leu Leu Ser Ala Val Ala Asp Val Arg Leu Tyr Ser 
145                 150                 155                 160 


Leu Met Lys Gln Leu Glu Asn Gln Glu Val Ala Arg Trp Val Phe Phe 
                165                 170                 175     


Cys Gln Leu Cys Ser Trp Phe Thr Trp Tyr Cys Cys Thr Arg Thr Leu 
            180                 185                 190         


Thr Asn Thr Met Glu Thr Val Leu Thr Ile Ile Ala Leu Phe Tyr Tyr 
        195                 200                 205             


Pro Leu Glu Gly Ser Lys Ser Met Asn Ser Val Lys Tyr Ser Ser Leu 
    210                 215                 220                 


Val Ala Leu Ala Phe Ile Ile Arg Pro Thr Ala Val Ile Leu Trp Thr 
225                 230                 235                 240 


Pro Leu Leu Phe Arg His Phe Cys Gln Glu Pro Arg Lys Leu Asp Leu 
                245                 250                 255     


Ile Leu His His Phe Leu Pro Val Gly Phe Val Thr Leu Ser Leu Ser 
            260                 265                 270         


Leu Met Ile Asp Arg Ile Phe Phe Gly Gln Trp Thr Leu Val Gln Phe 
        275                 280                 285             


Asn Phe Leu Lys Phe Asn Val Leu Gln Asn Trp Gly Thr Phe Tyr Gly 
    290                 295                 300                 


Ser His Pro Trp His Trp Tyr Phe Ser Gln Gly Phe Pro Val Ile Leu 
305                 310                 315                 320 


Gly Thr His Leu Pro Phe Phe Ile His Gly Cys Tyr Leu Ala Pro Lys 
                325                 330                 335     


Arg Tyr Arg Ile Leu Leu Val Thr Val Leu Trp Thr Leu Leu Val Tyr 
            340                 345                 350         


Ser Met Leu Ser His Lys Glu Phe Arg Phe Ile Tyr Pro Val Leu Pro 
        355                 360                 365             


Phe Cys Met Val Phe Cys Gly Tyr Ser Leu Thr His Leu Lys Thr Trp 
    370                 375                 380                 


Lys Lys Pro Ala Leu Ser Phe Leu Phe Leu Ser Asn Leu Phe Leu Ala 
385                 390                 395                 400 


Leu Tyr Thr Gly Leu Val His Gln Arg Gly Thr Leu Asp Val Met Ser 
                405                 410                 415     


His Ile Gln Lys Val Cys Tyr Asn Asn Pro Asn Lys Ser Ser Ala Ser 
            420                 425                 430         


Ile Phe Ile Met Met Pro Cys His Ser Thr Pro Tyr Tyr Ser His Val 
        435                 440                 445             


His Cys Pro Leu Pro Met Arg Phe Leu Gln Cys Pro Pro Asp Leu Thr 
    450                 455                 460                 


Gly Lys Ser His Tyr Leu Asp Glu Ala Asp Val Phe Tyr Leu Asn Pro 
465                 470                 475                 480 


Leu Asn Trp Leu His Arg Glu Phe His Asp Asp Ala Ser Leu Pro Thr 
                485                 490                 495     


His Leu Ile Thr Phe Ser Ile Leu Glu Glu Glu Ile Ser Ala Phe Leu 
            500                 505                 510         


Ile Ser Ser Asn Tyr Lys Arg Thr Ala Val Phe Phe His Thr His Leu 
        515                 520                 525             


Pro Glu Gly Arg Ile Gly Ser His Ile Tyr Val Tyr Glu Arg Lys Leu 
    530                 535                 540                 


Lys Gly Lys Phe Asn Met Lys Met Lys Phe 
545                 550                 


<210>  3150
<211>  1093
<212>  PRT
<213>  Homo sapiens

<400>  3150

Met Pro Ala Ala Gly Ser Asn Glu Pro Asp Gly Val Leu Ser Tyr Gln 
1               5                   10                  15      


Arg Pro Asp Glu Glu Ala Val Val Asp Gln Gly Gly Thr Ser Thr Ile 
            20                  25                  30          


Leu Asn Ile His Tyr Glu Lys Glu Glu Leu Glu Gly His Arg Thr Leu 
        35                  40                  45              


Tyr Val Gly Val Arg Met Pro Leu Gly Arg Gln Ser His Arg His His 
    50                  55                  60                  


Arg Thr His Gly Gln Lys His Arg Arg Arg Gly Arg Gly Lys Gly Ala 
65                  70                  75                  80  


Ser Gln Gly Glu Glu Gly Leu Glu Ala Leu Ala His Asp Thr Pro Ser 
                85                  90                  95      


Gln Arg Val Gln Phe Ile Leu Gly Thr Glu Glu Asp Glu Glu His Val 
            100                 105                 110         


Pro His Glu Leu Phe Thr Glu Leu Asp Glu Ile Cys Met Lys Glu Gly 
        115                 120                 125             


Glu Asp Ala Glu Trp Lys Glu Thr Ala Arg Trp Leu Lys Phe Glu Glu 
    130                 135                 140                 


Asp Val Glu Asp Gly Gly Glu Arg Trp Ser Lys Pro Tyr Val Ala Thr 
145                 150                 155                 160 


Leu Ser Leu His Ser Leu Phe Glu Leu Arg Ser Cys Leu Ile Asn Gly 
                165                 170                 175     


Thr Val Leu Leu Asp Met His Ala Asn Ser Ile Glu Glu Ile Ser Asp 
            180                 185                 190         


Leu Ile Leu Asp Gln Gln Glu Leu Ser Ser Asp Leu Asn Asp Ser Met 
        195                 200                 205             


Arg Val Lys Val Arg Glu Ala Leu Leu Lys Lys His His His Gln Asn 
    210                 215                 220                 


Glu Lys Lys Arg Asn Asn Leu Ile Pro Ile Val Arg Ser Phe Ala Glu 
225                 230                 235                 240 


Val Gly Lys Lys Gln Ser Asp Pro His Leu Met Asp Lys His Gly Gln 
                245                 250                 255     


Thr Val Ser Pro Gln Ser Val Pro Thr Thr Asn Leu Glu Val Lys Asn 
            260                 265                 270         


Gly Val Asn Cys Glu His Ser Pro Val Asp Leu Ser Lys Val Asp Leu 
        275                 280                 285             


His Phe Met Lys Lys Ile Pro Thr Gly Ala Glu Ala Ser Asn Val Leu 
    290                 295                 300                 


Val Gly Glu Val Asp Ile Leu Asp Arg Pro Ile Val Ala Phe Val Arg 
305                 310                 315                 320 


Leu Ser Pro Ala Val Leu Leu Ser Gly Leu Thr Glu Val Pro Ile Pro 
                325                 330                 335     


Thr Arg Phe Leu Phe Ile Leu Leu Gly Pro Val Gly Lys Gly Gln Gln 
            340                 345                 350         


Tyr His Glu Ile Gly Arg Ser Met Ala Thr Ile Met Thr Asp Glu Ile 
        355                 360                 365             


Phe His Asp Val Ala Tyr Lys Ala Lys Glu Arg Asp Asp Leu Leu Ala 
    370                 375                 380                 


Gly Ile Asp Glu Phe Leu Asp Gln Val Thr Val Leu Pro Pro Gly Glu 
385                 390                 395                 400 


Trp Asp Pro Ser Ile Arg Ile Glu Pro Pro Lys Asn Val Pro Ser Gln 
                405                 410                 415     


Glu Lys Arg Lys Met Pro Gly Val Pro Asn Gly Asn Val Cys His Ile 
            420                 425                 430         


Glu Gln Glu Pro His Gly Gly His Ser Gly Pro Glu Leu Gln Arg Thr 
        435                 440                 445             


Gly Arg Leu Phe Gly Gly Leu Val Leu Asp Ile Lys Arg Lys Ala Pro 
    450                 455                 460                 


Trp Tyr Trp Ser Asp Tyr Arg Asp Ala Leu Ser Leu Gln Cys Leu Ala 
465                 470                 475                 480 


Ser Phe Leu Phe Leu Tyr Cys Ala Cys Met Ser Pro Val Ile Thr Phe 
                485                 490                 495     


Gly Gly Leu Leu Gly Glu Ala Thr Glu Gly Arg Ile Ser Ala Ile Glu 
            500                 505                 510         


Ser Leu Phe Gly Ala Ser Met Thr Gly Ile Ala Tyr Ser Leu Phe Ala 
        515                 520                 525             


Gly Gln Ala Leu Thr Ile Leu Gly Ser Thr Gly Pro Val Leu Val Phe 
    530                 535                 540                 


Glu Lys Ile Leu Phe Lys Phe Cys Lys Asp Tyr Ala Leu Ser Tyr Leu 
545                 550                 555                 560 


Ser Leu Arg Ala Cys Ile Gly Leu Trp Thr Ala Phe Leu Cys Ile Val 
                565                 570                 575     


Leu Val Ala Thr Asp Ala Ser Ser Leu Val Cys Tyr Ile Thr Arg Phe 
            580                 585                 590         


Thr Glu Glu Ala Phe Ala Ser Leu Ile Cys Ile Ile Phe Ile Tyr Glu 
        595                 600                 605             


Ala Ile Glu Lys Leu Ile His Leu Ala Glu Thr Tyr Pro Ile His Met 
    610                 615                 620                 


His Ser Gln Leu Asp His Leu Ser Leu Tyr Tyr Cys Arg Cys Thr Leu 
625                 630                 635                 640 


Pro Glu Asn Pro Asn Asn His Thr Leu Gln Tyr Trp Lys Asp His Asn 
                645                 650                 655     


Ile Val Thr Ala Glu Val His Trp Ala Asn Leu Thr Val Ser Glu Cys 
            660                 665                 670         


Gln Glu Met His Gly Glu Phe Met Gly Ser Ala Cys Gly His His Gly 
        675                 680                 685             


Pro Tyr Thr Pro Asp Val Leu Phe Trp Ser Cys Ile Leu Phe Phe Thr 
    690                 695                 700                 


Thr Phe Ile Leu Ser Ser Thr Leu Lys Thr Phe Lys Thr Ser Arg Tyr 
705                 710                 715                 720 


Phe Pro Thr Arg Val Arg Ser Met Val Ser Asp Phe Ala Val Phe Leu 
                725                 730                 735     


Thr Ile Phe Thr Met Val Ile Ile Asp Phe Leu Ile Gly Val Pro Ser 
            740                 745                 750         


Pro Lys Leu Gln Val Pro Ser Val Phe Lys Pro Thr Arg Asp Asp Arg 
        755                 760                 765             


Gly Trp Ile Ile Asn Pro Ile Gly Pro Asn Pro Trp Trp Thr Val Ile 
    770                 775                 780                 


Ala Ala Ile Ile Pro Ala Leu Leu Cys Thr Ile Leu Ile Phe Met Asp 
785                 790                 795                 800 


Gln Gln Ile Thr Ala Val Ile Ile Asn Arg Lys Glu His Lys Leu Lys 
                805                 810                 815     


Lys Gly Cys Gly Tyr His Leu Asp Leu Leu Met Val Ala Ile Met Leu 
            820                 825                 830         


Gly Val Cys Ser Ile Met Gly Leu Pro Trp Phe Val Ala Ala Thr Val 
        835                 840                 845             


Leu Ser Ile Thr His Val Asn Ser Leu Lys Leu Glu Ser Glu Cys Ser 
    850                 855                 860                 


Ala Pro Gly Glu Gln Pro Lys Phe Leu Gly Ile Arg Glu Gln Arg Val 
865                 870                 875                 880 


Thr Gly Leu Met Ile Phe Val Leu Met Gly Cys Ser Val Phe Met Thr 
                885                 890                 895     


Ala Ile Leu Lys Phe Ile Pro Met Pro Val Leu Tyr Gly Val Phe Leu 
            900                 905                 910         


Tyr Met Gly Val Ser Ser Leu Gln Gly Ile Gln Phe Phe Asp Arg Leu 
        915                 920                 925             


Lys Leu Phe Gly Met Pro Ala Lys His Gln Pro Asp Phe Ile Tyr Leu 
    930                 935                 940                 


Arg His Val Pro Leu Arg Lys Val His Leu Phe Thr Leu Ile Gln Leu 
945                 950                 955                 960 


Thr Cys Leu Val Leu Leu Trp Val Ile Lys Ala Ser Pro Ala Ala Ile 
                965                 970                 975     


Val Phe Pro Met Met Val Leu Ala Leu Val Phe Val Arg Lys Val Met 
            980                 985                 990         


Asp Leu Cys Phe Ser Lys Arg Glu  Leu Ser Trp Leu Asp  Asp Leu Met 
        995                 1000                 1005             


Pro Glu  Ser Lys Lys Lys Lys  Leu Asp Asp Ala Lys  Lys Lys Ala 
    1010                 1015                 1020             


Lys Glu  Glu Glu Glu Ala Glu  Lys Met Leu Glu Ile  Gly Gly Asp 
    1025                 1030                 1035             


Lys Phe  Pro Leu Glu Ser Arg  Lys Leu Leu Ser Ser  Pro Gly Lys 
    1040                 1045                 1050             


Asn Ile  Ser Cys Arg Cys Asp  Pro Ser Glu Ile Asn  Ile Ser Asp 
    1055                 1060                 1065             


Glu Met  Pro Lys Thr Thr Val  Trp Lys Ala Leu Ser  Met Asn Ser 
    1070                 1075                 1080             


Gly Asn  Ala Lys Glu Lys Ser  Leu Phe Asn 
    1085                 1090             


<210>  3151
<211>  562
<212>  PRT
<213>  Homo sapiens

<400>  3151

Met Arg Pro Glu Pro Gly Gly Cys Cys Cys Arg Arg Thr Val Arg Ala 
1               5                   10                  15      


Asn Gly Cys Val Ala Asn Gly Glu Val Arg Asn Gly Tyr Val Arg Ser 
            20                  25                  30          


Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Gln Ile His His Val 
        35                  40                  45              


Thr Gln Asn Gly Gly Leu Tyr Lys Arg Pro Phe Asn Glu Ala Phe Glu 
    50                  55                  60                  


Glu Thr Pro Met Leu Val Ala Val Leu Thr Tyr Val Gly Tyr Gly Val 
65                  70                  75                  80  


Leu Thr Leu Phe Gly Tyr Leu Arg Asp Phe Leu Arg Tyr Trp Arg Ile 
                85                  90                  95      


Glu Lys Cys His His Ala Thr Glu Arg Glu Glu Gln Lys Asp Phe Val 
            100                 105                 110         


Ser Leu Tyr Gln Asp Phe Glu Asn Phe Tyr Thr Arg Asn Leu Tyr Met 
        115                 120                 125             


Arg Ile Arg Asp Asn Trp Asn Arg Pro Ile Cys Ser Val Pro Gly Ala 
    130                 135                 140                 


Arg Val Asp Ile Met Glu Arg Gln Ser His Asp Tyr Asn Trp Ser Phe 
145                 150                 155                 160 


Lys Tyr Thr Gly Asn Ile Ile Lys Gly Val Ile Asn Met Gly Ser Tyr 
                165                 170                 175     


Asn Tyr Leu Gly Phe Ala Arg Asn Thr Gly Ser Cys Gln Glu Ala Ala 
            180                 185                 190         


Ala Lys Val Leu Glu Glu Tyr Gly Ala Gly Val Cys Ser Thr Arg Gln 
        195                 200                 205             


Glu Ile Gly Asn Leu Asp Lys His Glu Glu Leu Glu Glu Leu Val Ala 
    210                 215                 220                 


Arg Phe Leu Gly Val Glu Ala Ala Met Ala Tyr Gly Met Gly Phe Ala 
225                 230                 235                 240 


Thr Asn Ser Met Asn Ile Pro Ala Leu Val Gly Lys Gly Cys Leu Ile 
                245                 250                 255     


Leu Ser Asp Glu Leu Asn His Ala Ser Leu Val Leu Gly Ala Arg Leu 
            260                 265                 270         


Ser Gly Ala Thr Ile Arg Ile Phe Lys His Asn Asn Met Gln Ser Leu 
        275                 280                 285             


Glu Lys Leu Leu Lys Asp Ala Ile Val Tyr Gly Gln Pro Arg Thr Arg 
    290                 295                 300                 


Arg Pro Trp Lys Lys Ile Leu Ile Leu Val Glu Gly Ile Tyr Ser Met 
305                 310                 315                 320 


Glu Gly Ser Ile Val Arg Leu Pro Glu Val Ile Ala Leu Lys Lys Lys 
                325                 330                 335     


Tyr Lys Ala Tyr Leu Tyr Leu Asp Glu Ala His Ser Ile Gly Ala Leu 
            340                 345                 350         


Gly Pro Thr Gly Arg Gly Val Val Glu Tyr Phe Gly Leu Asp Pro Glu 
        355                 360                 365             


Asp Val Asp Val Met Met Gly Thr Phe Thr Lys Ser Phe Gly Ala Ser 
    370                 375                 380                 


Gly Gly Tyr Ile Gly Gly Lys Lys Glu Leu Ile Asp Tyr Leu Arg Thr 
385                 390                 395                 400 


His Ser His Ser Ala Val Tyr Ala Thr Ser Leu Ser Pro Pro Val Val 
                405                 410                 415     


Glu Gln Ile Ile Thr Ser Met Lys Cys Ile Met Gly Gln Asp Gly Thr 
            420                 425                 430         


Ser Leu Gly Lys Glu Cys Val Gln Gln Leu Ala Glu Asn Thr Arg Tyr 
        435                 440                 445             


Phe Arg Arg Arg Leu Lys Glu Met Gly Phe Ile Ile Tyr Gly Asn Glu 
    450                 455                 460                 


Asp Ser Pro Val Val Pro Leu Met Leu Tyr Met Pro Ala Lys Ile Gly 
465                 470                 475                 480 


Ala Phe Gly Arg Glu Met Leu Lys Arg Asn Ile Gly Val Val Val Val 
                485                 490                 495     


Gly Phe Pro Ala Thr Pro Ile Ile Glu Ser Arg Ala Arg Phe Cys Leu 
            500                 505                 510         


Ser Ala Ala His Thr Lys Glu Ile Leu Asp Thr Ala Leu Lys Glu Ile 
        515                 520                 525             


Asp Glu Val Gly Asp Leu Leu Gln Leu Lys Tyr Ser Arg His Arg Leu 
    530                 535                 540                 


Val Pro Leu Leu Asp Arg Pro Phe Asp Glu Thr Thr Tyr Glu Glu Thr 
545                 550                 555                 560 


Glu Asp 
        


<210>  3152
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  3152

Met Ser Asp Phe Asp Ser Asn Pro Phe Ala Asp Pro Asp Leu Asn Asn 
1               5                   10                  15      


Pro Phe Lys Asp Pro Ser Val Thr Gln Val Thr Arg Asn Val Pro Pro 
            20                  25                  30          


Gly Leu Asp Glu Tyr Asn Pro Phe Ser Asp Ser Arg Thr Pro Pro Pro 
        35                  40                  45              


Gly Gly Val Lys Met Pro Asn Val Pro Asn Thr Gln Pro Ala Ile Met 
    50                  55                  60                  


Lys Pro Thr Glu Glu His Pro Ala Tyr Thr Gln Ile Ala Lys Glu His 
65                  70                  75                  80  


Ala Leu Ala Gln Ala Glu Leu Leu Lys Arg Gln Glu Glu Leu Glu Arg 
                85                  90                  95      


Lys Ala Ala Glu Leu Asp Arg Arg Glu Arg Glu Met Gln Asn Leu Ser 
            100                 105                 110         


Gln His Gly Arg Lys Asn Asn Trp Pro Pro Leu Pro Ser Asn Phe Pro 
        115                 120                 125             


Val Gly Pro Cys Phe Tyr Gln Asp Phe Ser Val Asp Ile Pro Val Glu 
    130                 135                 140                 


Phe Gln Lys Thr Val Lys Leu Met Tyr Tyr Leu Trp Met Phe His Ala 
145                 150                 155                 160 


Val Thr Leu Phe Leu Asn Ile Phe Gly Cys Leu Ala Trp Phe Cys Val 
                165                 170                 175     


Asp Ser Ala Arg Ala Val Asp Phe Gly Leu Ser Ile Leu Trp Phe Leu 
            180                 185                 190         


Leu Phe Thr Pro Cys Ser Phe Val Cys Trp Tyr Arg Pro Leu Tyr Gly 
        195                 200                 205             


Ala Phe Arg Ser Asp Ser Ser Phe Arg Phe Phe Val Phe Phe Phe Val 
    210                 215                 220                 


Tyr Ile Cys Gln Phe Ala Val His Val Leu Gln Ala Ala Gly Phe His 
225                 230                 235                 240 


Asn Trp Gly Asn Cys Gly Trp Ile Ser Ser Leu Thr Gly Leu Asn Gln 
                245                 250                 255     


Asn Ile Pro Val Gly Ile Met Met Ile Ile Ile Ala Ala Leu Phe Thr 
            260                 265                 270         


Ala Ser Ala Val Ile Ser Leu Val Met Phe Lys Lys Val His Gly Leu 
        275                 280                 285             


Tyr Arg Thr Thr Gly Ala Ser Phe Glu Lys Ala Gln Gln Glu Phe Ala 
    290                 295                 300                 


Thr Gly Val Met Ser Asn Lys Thr Val Gln Thr Ala Ala Ala Asn Ala 
305                 310                 315                 320 


Ala Ser Thr Ala Ala Ser Ser Ala Ala Gln Asn Ala Phe Lys Gly Asn 
                325                 330                 335     


Gln Ile 
        


<210>  3153
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  3153

Met Val Lys Ile Ala Phe Asn Thr Pro Thr Ala Val Gln Lys Glu Glu 
1               5                   10                  15      


Ala Arg Gln Asp Val Glu Ala Leu Leu Ser Arg Thr Val Arg Thr Gln 
            20                  25                  30          


Ile Leu Thr Gly Lys Glu Leu Arg Val Ala Thr Gln Glu Lys Glu Gly 
        35                  40                  45              


Ser Ser Gly Arg Cys Met Leu Thr Leu Leu Gly Leu Ser Phe Ile Leu 
    50                  55                  60                  


Ala Gly Leu Ile Val Gly Gly Ala Cys Ile Tyr Lys Tyr Phe Met Pro 
65                  70                  75                  80  


Lys Ser Thr Ile Tyr Arg Gly Glu Met Cys Phe Phe Asp Ser Glu Asp 
                85                  90                  95      


Pro Ala Asn Ser Leu Arg Gly Gly Glu Pro Asn Phe Leu Pro Val Thr 
            100                 105                 110         


Glu Glu Ala Asp Ile Arg Glu Asp Asp Asn Ile Ala Ile Ile Asp Val 
        115                 120                 125             


Pro Val Pro Ser Phe Ser Asp Ser Asp Pro Ala Ala Ile Ile His Asp 
    130                 135                 140                 


Phe Glu Lys Gly Met Thr Ala Tyr Leu Asp Leu Leu Leu Gly Asn Cys 
145                 150                 155                 160 


Tyr Leu Met Pro Leu Asn Thr Ser Ile Val Met Pro Pro Lys Asn Leu 
                165                 170                 175     


Val Glu Leu Phe Gly Lys Leu Ala Ser Gly Arg Tyr Leu Pro Gln Thr 
            180                 185                 190         


Tyr Val Val Arg Glu Asp Leu Val Ala Val Glu Glu Ile Arg Asp Val 
        195                 200                 205             


Ser Asn Leu Gly Ile Phe Ile Tyr Gln Leu Cys Asn Asn Arg Lys Ser 
    210                 215                 220                 


Phe Arg Leu Arg Arg Arg Asp Leu Leu Leu Gly Phe Asn Lys Arg Ala 
225                 230                 235                 240 


Ile Asp Lys Cys Trp Lys Ile Arg His Phe Pro Asn Glu Phe Ile Val 
                245                 250                 255     


Glu Thr Lys Ile Cys Gln Glu 
            260             


<210>  3154
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  3154

Met Ala Ala Glu Ala Asp Gly Pro Leu Lys Arg Leu Leu Val Pro Ile 
1               5                   10                  15      


Leu Leu Pro Glu Lys Cys Tyr Asp Gln Leu Phe Val Gln Trp Asp Leu 
            20                  25                  30          


Leu His Val Pro Cys Leu Lys Ile Leu Leu Ser Lys Gly Leu Gly Leu 
        35                  40                  45              


Gly Ile Val Ala Gly Ser Leu Leu Val Lys Leu Pro Gln Val Phe Lys 
    50                  55                  60                  


Ile Leu Gly Ala Lys Ser Ala Glu Gly Leu Ser Leu Gln Ser Val Met 
65                  70                  75                  80  


Leu Glu Leu Val Ala Leu Thr Gly Thr Met Val Tyr Ser Ile Thr Asn 
                85                  90                  95      


Asn Phe Pro Phe Ser Ser Trp Gly Glu Ala Leu Phe Leu Met Leu Gln 
            100                 105                 110         


Thr Ile Thr Ile Cys Phe Leu Val Met His Tyr Arg Gly Gln Thr Val 
        115                 120                 125             


Lys Gly Val Ala Phe Leu Ala Cys Tyr Gly Leu Val Leu Leu Val Leu 
    130                 135                 140                 


Leu Ser Pro Leu Thr Pro Leu Thr Val Val Thr Leu Leu Gln Ala Ser 
145                 150                 155                 160 


Asn Val Pro Ala Val Val Val Gly Arg Leu Leu Gln Ala Ala Thr Asn 
                165                 170                 175     


Tyr His Asn Gly His Thr Gly Gln Leu Ser Ala Ile Thr Val Phe Leu 
            180                 185                 190         


Leu Phe Gly Gly Ser Leu Ala Arg Ile Phe Thr Ser Ile Gln Glu Thr 
        195                 200                 205             


Gly Asp Pro Leu Met Ala Gly Thr Phe Val Val Ser Ser Leu Cys Asn 
    210                 215                 220                 


Gly Leu Ile Ala Ala Gln Leu Leu Phe Tyr Trp Asn Ala Lys Pro Pro 
225                 230                 235                 240 


His Lys Gln Lys Lys Ala Gln 
                245         


<210>  3155
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  3155

Met Ala Ala Gly Thr Ser Ser Tyr Trp Glu Asp Leu Arg Lys Gln Ala 
1               5                   10                  15      


Arg Gln Leu Glu Asn Glu Leu Asp Leu Lys Leu Val Ser Phe Ser Lys 
            20                  25                  30          


Leu Cys Thr Ser Tyr Ser His Ser Ser Thr Arg Asp Gly Arg Arg Asp 
        35                  40                  45              


Arg Tyr Ser Ser Asp Thr Thr Pro Leu Leu Asn Gly Ser Ser Gln Asp 
    50                  55                  60                  


Arg Met Phe Glu Thr Met Ala Ile Glu Ile Glu Gln Leu Leu Ala Arg 
65                  70                  75                  80  


Leu Thr Gly Val Asn Asp Lys Met Ala Glu Tyr Thr Asn Ser Ala Gly 
                85                  90                  95      


Val Pro Ser Leu Asn Ala Ala Leu Met His Thr Leu Gln Arg His Arg 
            100                 105                 110         


Asp Ile Leu Gln Asp Tyr Thr His Glu Phe His Lys Thr Lys Ala Asn 
        115                 120                 125             


Phe Met Ala Ile Arg Glu Arg Glu Asn Leu Met Gly Ser Val Arg Lys 
    130                 135                 140                 


Asp Ile Glu Ser Tyr Lys Ser Gly Ser Gly Val Asn Asn Arg Arg Thr 
145                 150                 155                 160 


Glu Leu Phe Leu Lys Glu His Asp His Leu Arg Asn Ser Asp Arg Leu 
                165                 170                 175     


Ile Glu Glu Thr Ile Ser Ile Ala Met Ala Thr Lys Glu Asn Met Thr 
            180                 185                 190         


Ser Gln Arg Gly Met Leu Lys Ser Ile His Ser Lys Met Asn Thr Leu 
        195                 200                 205             


Ala Asn Arg Phe Pro Ala Val Asn Ser Leu Ile Gln Arg Ile Asn Leu 
    210                 215                 220                 


Arg Lys Arg Arg Asp Ser Leu Ile Leu Gly Gly Val Ile Gly Ile Cys 
225                 230                 235                 240 


Thr Ile Leu Leu Leu Leu Tyr Ala Phe His 
                245                 250 


<210>  3156
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  3156

Met Ala Ala Pro Lys Gly Ser Leu Trp Val Arg Thr Gln Leu Gly Leu 
1               5                   10                  15      


Pro Pro Leu Leu Leu Leu Thr Met Ala Leu Ala Gly Gly Ser Gly Thr 
            20                  25                  30          


Ala Ser Ala Glu Ala Phe Asp Ser Val Leu Gly Asp Thr Ala Ser Cys 
        35                  40                  45              


His Arg Ala Cys Gln Leu Thr Tyr Pro Leu His Thr Tyr Pro Lys Glu 
    50                  55                  60                  


Glu Glu Leu Tyr Ala Cys Gln Arg Gly Cys Arg Leu Phe Ser Ile Cys 
65                  70                  75                  80  


Gln Phe Val Asp Asp Gly Ile Asp Leu Asn Arg Thr Lys Leu Glu Cys 
                85                  90                  95      


Glu Ser Ala Cys Thr Glu Ala Tyr Ser Gln Ser Asp Glu Gln Tyr Ala 
            100                 105                 110         


Cys His Leu Gly Cys Gln Asn Gln Leu Pro Phe Ala Glu Leu Arg Gln 
        115                 120                 125             


Glu Gln Leu Met Ser Leu Met Pro Lys Met His Leu Leu Phe Pro Leu 
    130                 135                 140                 


Thr Leu Val Arg Ser Phe Trp Ser Asp Met Met Asp Ser Ala Gln Ser 
145                 150                 155                 160 


Phe Ile Thr Ser Ser Trp Thr Phe Tyr Leu Gln Ala Asp Asp Gly Lys 
                165                 170                 175     


Ile Val Ile Phe Gln Ser Lys Pro Glu Ile Gln Tyr Ala Pro His Leu 
            180                 185                 190         


Glu Gln Glu Pro Thr Asn Leu Arg Glu Ser Ser Leu Ser Lys Met Ser 
        195                 200                 205             


Tyr Leu Gln Met Arg Asn Ser Gln Ala His Arg Asn Phe Leu Glu Asp 
    210                 215                 220                 


Gly Glu Ser Asp Gly Phe Leu Arg Cys Leu Ser Leu Asn Ser Gly Trp 
225                 230                 235                 240 


Ile Leu Thr Thr Thr Leu Val Leu Ser Val Met Val Leu Leu Trp Ile 
                245                 250                 255     


Cys Cys Ala Thr Val Ala Thr Ala Val Glu Gln Tyr Val Pro Ser Glu 
            260                 265                 270         


Lys Leu Ser Ile Tyr Gly Asp Leu Glu Phe Met Asn Glu Gln Lys Leu 
        275                 280                 285             


Asn Arg Tyr Pro Ala Ser Ser Leu Val Val Val Arg Ser Lys Thr Glu 
    290                 295                 300                 


Asp His Glu Glu Ala Gly Pro Leu Pro Thr Lys Val Asn Leu Ala His 
305                 310                 315                 320 


Ser Glu Ile 
            


<210>  3157
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  3157

Met Ala Asp Ser Val Lys Thr Phe Leu Gln Asp Leu Ala Arg Gly Ile 
1               5                   10                  15      


Lys Asp Ser Ile Trp Gly Ile Cys Thr Ile Ser Lys Leu Asp Ala Arg 
            20                  25                  30          


Ile Gln Gln Lys Arg Glu Glu Gln Arg Arg Arg Arg Ala Ser Ser Val 
        35                  40                  45              


Leu Ala Gln Arg Arg Ala Gln Ser Ile Glu Arg Lys Gln Glu Ser Glu 
    50                  55                  60                  


Pro Arg Ile Val Ser Arg Ile Phe Gln Cys Cys Ala Trp Asn Gly Gly 
65                  70                  75                  80  


Val Phe Trp Phe Ser Leu Leu Leu Phe Tyr Arg Val Phe Ile Pro Val 
                85                  90                  95      


Leu Gln Ser Val Thr Ala Arg Ile Ile Gly Asp Pro Ser Leu His Gly 
            100                 105                 110         


Asp Val Trp Ser Trp Leu Glu Phe Phe Leu Thr Ser Ile Phe Ser Ala 
        115                 120                 125             


Leu Trp Val Leu Pro Leu Phe Val Leu Ser Lys Val Val Asn Ala Ile 
    130                 135                 140                 


Trp Phe Gln Asp Ile Ala Asp Leu Ala Phe Glu Val Ser Gly Arg Lys 
145                 150                 155                 160 


Pro His Pro Phe Pro Ser Val Ser Lys Ile Ile Ala Asp Met Leu Phe 
                165                 170                 175     


Asn Leu Leu Leu Gln Ala Leu Phe Leu Ile Gln Gly Met Phe Val Ser 
            180                 185                 190         


Leu Phe Pro Ile His Leu Val Gly Gln Leu Val Ser Leu Leu His Met 
        195                 200                 205             


Ser Leu Leu Tyr Ser Leu Tyr Cys Phe Glu Tyr Arg Trp Phe Asn Lys 
    210                 215                 220                 


Gly Ile Glu Met His Gln Arg Leu Ser Asn Ile Glu Arg Asn Trp Pro 
225                 230                 235                 240 


Tyr Tyr Phe Gly Phe Gly Leu Pro Leu Ala Phe Leu Thr Ala Met Gln 
                245                 250                 255     


Ser Ser Tyr Ile Ile Ser Gly Cys Leu Phe Ser Ile Leu Phe Pro Leu 
            260                 265                 270         


Phe Ile Ile Ser Ala Asn Glu Ala Lys Thr Pro Gly Lys Ala Tyr Leu 
        275                 280                 285             


Phe Gln Leu Arg Leu Phe Ser Leu Val Val Phe Leu Ser Asn Arg Leu 
    290                 295                 300                 


Phe His Lys Thr Val Tyr Leu Gln Ser Ala Leu Ser Ser Ser Thr Ser 
305                 310                 315                 320 


Ala Glu Lys Phe Pro Ser Pro His Pro Ser Pro Ala Lys Leu Lys Ala 
                325                 330                 335     


Thr Ala Gly His 
            340 


<210>  3158
<211>  850
<212>  PRT
<213>  Homo sapiens

<400>  3158

Met Arg Gln Val Cys Cys Ser Ala Leu Pro Pro Pro Pro Leu Glu Lys 
1               5                   10                  15      


Gly Arg Cys Ser Ser Tyr Ser Asp Ser Ser Ser Ser Ser Ser Glu Arg 
            20                  25                  30          


Ser Ser Ser Ser Ser Ser Ser Ser Ser Glu Ser Gly Ser Ser Ser Arg 
        35                  40                  45              


Ser Ser Ser Asn Asn Ser Ser Ile Ser Arg Pro Ala Ala Pro Pro Glu 
    50                  55                  60                  


Pro Arg Pro Gln Gln Gln Pro Gln Pro Arg Ser Pro Ala Ala Arg Arg 
65                  70                  75                  80  


Ala Ala Ala Arg Ser Arg Ala Ala Ala Ala Gly Gly Met Arg Arg Asp 
                85                  90                  95      


Pro Ala Pro Gly Phe Ser Met Leu Leu Phe Gly Val Ser Leu Ala Cys 
            100                 105                 110         


Tyr Ser Pro Ser Leu Lys Ser Val Gln Asp Gln Ala Tyr Lys Ala Pro 
        115                 120                 125             


Val Val Val Glu Gly Lys Val Gln Gly Leu Val Pro Ala Gly Gly Ser 
    130                 135                 140                 


Ser Ser Asn Ser Thr Arg Glu Pro Pro Ala Ser Gly Arg Val Ala Leu 
145                 150                 155                 160 


Val Lys Val Leu Asp Lys Trp Pro Leu Arg Ser Gly Gly Leu Gln Arg 
                165                 170                 175     


Glu Gln Val Ile Ser Val Gly Ser Cys Val Pro Leu Glu Arg Asn Gln 
            180                 185                 190         


Arg Tyr Ile Phe Phe Leu Glu Pro Thr Glu Gln Pro Leu Val Phe Lys 
        195                 200                 205             


Thr Ala Phe Ala Pro Leu Asp Thr Asn Gly Lys Asn Leu Lys Lys Glu 
    210                 215                 220                 


Val Gly Lys Ile Leu Cys Thr Asp Cys Ala Thr Arg Pro Lys Leu Lys 
225                 230                 235                 240 


Lys Met Lys Ser Gln Thr Gly Gln Val Gly Glu Lys Gln Ser Leu Lys 
                245                 250                 255     


Cys Glu Ala Ala Ala Gly Asn Pro Gln Pro Ser Tyr Arg Trp Phe Lys 
            260                 265                 270         


Asp Gly Lys Glu Leu Asn Arg Ser Arg Asp Ile Arg Ile Lys Tyr Gly 
        275                 280                 285             


Asn Gly Arg Lys Asn Ser Arg Leu Gln Phe Asn Lys Val Lys Val Glu 
    290                 295                 300                 


Asp Ala Gly Glu Tyr Val Cys Glu Ala Glu Asn Ile Leu Gly Lys Asp 
305                 310                 315                 320 


Thr Val Arg Gly Arg Leu Tyr Val Asn Ser Val Ser Thr Thr Leu Ser 
                325                 330                 335     


Ser Trp Ser Gly His Ala Arg Lys Cys Asn Glu Thr Ala Lys Ser Tyr 
            340                 345                 350         


Cys Val Asn Gly Gly Val Cys Tyr Tyr Ile Glu Gly Ile Asn Gln Leu 
        355                 360                 365             


Ser Cys Lys Cys Pro Asn Gly Phe Phe Gly Gln Arg Cys Leu Glu Lys 
    370                 375                 380                 


Leu Pro Leu Arg Leu Tyr Met Pro Asp Pro Lys Gln Lys Ala Glu Glu 
385                 390                 395                 400 


Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Val Ala Leu 
                405                 410                 415     


Leu Val Val Gly Ile Val Cys Val Val Ala Tyr Cys Lys Thr Lys Lys 
            420                 425                 430         


Gln Arg Lys Gln Met His Asn His Leu Arg Gln Asn Met Cys Pro Ala 
        435                 440                 445             


His Gln Asn Arg Ser Leu Ala Asn Gly Pro Ser His Pro Arg Leu Asp 
    450                 455                 460                 


Pro Glu Glu Ile Gln Met Ala Asp Tyr Ile Ser Lys Asn Val Pro Ala 
465                 470                 475                 480 


Thr Asp His Val Ile Arg Arg Glu Thr Glu Thr Thr Phe Ser Gly Ser 
                485                 490                 495     


His Ser Cys Ser Pro Ser His His Cys Ser Thr Ala Thr Pro Thr Ser 
            500                 505                 510         


Ser His Arg His Glu Ser His Thr Trp Ser Leu Glu Arg Ser Glu Ser 
        515                 520                 525             


Leu Thr Ser Asp Ser Gln Ser Gly Ile Met Leu Ser Ser Val Gly Thr 
    530                 535                 540                 


Ser Lys Cys Asn Ser Pro Ala Cys Val Glu Ala Arg Ala Arg Arg Ala 
545                 550                 555                 560 


Ala Ala Tyr Asn Leu Glu Glu Arg Arg Arg Ala Thr Ala Pro Pro Tyr 
                565                 570                 575     


His Asp Ser Val Asp Ser Leu Arg Asp Ser Pro His Ser Glu Arg Tyr 
            580                 585                 590         


Val Ser Ala Leu Thr Thr Pro Ala Arg Leu Ser Pro Val Asp Phe His 
        595                 600                 605             


Tyr Ser Leu Ala Thr Gln Val Pro Thr Phe Glu Ile Thr Ser Pro Asn 
    610                 615                 620                 


Ser Ala His Ala Val Ser Leu Pro Pro Ala Ala Pro Ile Ser Tyr Arg 
625                 630                 635                 640 


Leu Ala Glu Gln Gln Pro Leu Leu Arg His Pro Ala Pro Pro Gly Pro 
                645                 650                 655     


Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Ala Asp Met Gln Arg 
            660                 665                 670         


Ser Tyr Asp Ser Tyr Tyr Tyr Pro Ala Ala Gly Pro Gly Pro Arg Arg 
        675                 680                 685             


Gly Thr Cys Ala Leu Gly Gly Ser Leu Gly Ser Leu Pro Ala Ser Pro 
    690                 695                 700                 


Phe Arg Ile Pro Glu Asp Asp Glu Tyr Glu Thr Thr Gln Glu Cys Ala 
705                 710                 715                 720 


Pro Pro Pro Pro Pro Arg Pro Arg Ala Arg Gly Ala Ser Arg Arg Thr 
                725                 730                 735     


Ser Ala Gly Pro Arg Arg Trp Arg Arg Ser Arg Leu Asn Gly Leu Ala 
            740                 745                 750         


Ala Gln Arg Ala Arg Ala Ala Arg Asp Ser Leu Ser Leu Ser Ser Gly 
        755                 760                 765             


Ser Gly Gly Gly Ser Ala Ser Ala Ser Asp Asp Asp Ala Asp Asp Ala 
    770                 775                 780                 


Asp Gly Ala Leu Ala Ala Glu Ser Thr Pro Phe Leu Gly Leu Arg Gly 
785                 790                 795                 800 


Ala His Asp Ala Leu Arg Ser Asp Ser Pro Pro Leu Cys Pro Ala Ala 
                805                 810                 815     


Asp Ser Arg Thr Tyr Tyr Ser Leu Asp Ser His Ser Thr Arg Ala Ser 
            820                 825                 830         


Ser Arg His Ser Arg Gly Pro Pro Pro Arg Ala Lys Gln Asp Ser Ala 
        835                 840                 845             


Pro Leu 
    850 


<210>  3159
<211>  814
<212>  PRT
<213>  Homo sapiens

<400>  3159

Met Ala Val Gln Arg Ala Ala Ser Pro Arg Arg Pro Pro Ala Pro Leu 
1               5                   10                  15      


Trp Pro Arg Leu Leu Leu Pro Leu Leu Leu Leu Leu Leu Pro Ala Pro 
            20                  25                  30          


Ser Glu Gly Leu Gly His Ser Ala Glu Leu Ala Phe Ala Val Glu Pro 
        35                  40                  45              


Ser Asp Asp Val Ala Val Pro Gly Gln Pro Ile Val Leu Asp Cys Arg 
    50                  55                  60                  


Val Glu Gly Thr Pro Pro Val Arg Ile Thr Trp Arg Lys Asn Gly Val 
65                  70                  75                  80  


Glu Leu Pro Glu Ser Thr His Ser Thr Leu Leu Ala Asn Gly Ser Leu 
                85                  90                  95      


Met Ile Arg His Phe Arg Leu Glu Pro Gly Gly Ser Pro Ser Asp Glu 
            100                 105                 110         


Gly Asp Tyr Glu Cys Val Ala Gln Asn Arg Phe Gly Leu Val Val Ser 
        115                 120                 125             


Arg Lys Ala Arg Ile Gln Ala Ala Thr Met Ser Asp Phe His Val His 
    130                 135                 140                 


Pro Gln Ala Thr Val Gly Glu Glu Gly Gly Val Ala Arg Phe Gln Cys 
145                 150                 155                 160 


Gln Ile His Gly Leu Pro Lys Pro Leu Ile Thr Trp Glu Lys Asn Arg 
                165                 170                 175     


Val Pro Ile Asp Thr Asp Asn Glu Arg Tyr Thr Leu Leu Pro Lys Gly 
            180                 185                 190         


Val Leu Gln Ile Thr Gly Leu Arg Ala Glu Asp Gly Gly Ile Phe His 
        195                 200                 205             


Cys Val Ala Ser Asn Ile Ala Ser Ile Arg Ile Ser His Gly Ala Arg 
    210                 215                 220                 


Leu Thr Val Ser Gly Ser Gly Ser Gly Ala Tyr Lys Glu Pro Ala Ile 
225                 230                 235                 240 


Leu Val Gly Pro Glu Asn Leu Thr Leu Thr Val His Gln Thr Ala Val 
                245                 250                 255     


Leu Glu Cys Val Ala Thr Gly Asn Pro Arg Pro Ile Val Ser Trp Ser 
            260                 265                 270         


Arg Leu Asp Gly Arg Pro Ile Gly Val Glu Gly Ile Gln Val Leu Gly 
        275                 280                 285             


Thr Gly Asn Leu Ile Ile Ser Asp Val Thr Val Gln His Ser Gly Val 
    290                 295                 300                 


Tyr Val Cys Ala Ala Asn Arg Pro Gly Thr Arg Val Arg Arg Thr Ala 
305                 310                 315                 320 


Gln Gly Arg Leu Val Val Gln Ala Pro Ala Glu Phe Val Gln His Pro 
                325                 330                 335     


Gln Ser Ile Ser Arg Pro Ala Gly Thr Thr Ala Met Phe Thr Cys Gln 
            340                 345                 350         


Ala Gln Gly Glu Pro Pro Pro His Val Thr Trp Leu Lys Asn Gly Gln 
        355                 360                 365             


Val Leu Gly Pro Gly Gly His Val Arg Leu Lys Asn Asn Asn Ser Thr 
    370                 375                 380                 


Leu Thr Ile Ser Gly Ile Gly Pro Glu Asp Glu Ala Ile Tyr Gln Cys 
385                 390                 395                 400 


Val Ala Glu Asn Ser Ala Gly Ser Ser Gln Ala Ser Ala Arg Leu Thr 
                405                 410                 415     


Val Leu Trp Ala Glu Gly Leu Pro Gly Pro Pro Arg Asn Val Arg Ala 
            420                 425                 430         


Val Ser Val Ser Ser Thr Glu Val Arg Val Ser Trp Ser Glu Pro Leu 
        435                 440                 445             


Ala Asn Thr Lys Glu Ile Ile Gly Tyr Val Leu His Ile Arg Lys Ala 
    450                 455                 460                 


Ala Asp Pro Pro Glu Leu Glu Tyr Gln Glu Ala Val Ser Lys Ser Thr 
465                 470                 475                 480 


Phe Gln His Leu Val Ser Asp Leu Glu Pro Ser Thr Ala Tyr Ser Phe 
                485                 490                 495     


Tyr Ile Lys Ala Tyr Thr Pro Arg Gly Ala Ser Ser Ala Ser Val Pro 
            500                 505                 510         


Thr Leu Ala Ser Thr Leu Gly Glu Ala Pro Ala Pro Pro Pro Leu Ser 
        515                 520                 525             


Val Arg Val Leu Gly Ser Ser Ser Leu Gln Leu Leu Trp Glu Pro Trp 
    530                 535                 540                 


Pro Arg Leu Ala Gln His Glu Gly Gly Phe Lys Leu Phe Tyr Arg Pro 
545                 550                 555                 560 


Ala Ser Lys Thr Ser Phe Thr Gly Pro Ile Leu Leu Pro Gly Thr Val 
                565                 570                 575     


Ser Ser Tyr Asn Leu Ser Gln Leu Asp Pro Thr Ala Val Tyr Glu Val 
            580                 585                 590         


Lys Leu Leu Ala Tyr Asn Gln His Gly Asp Gly Asn Ala Thr Val Arg 
        595                 600                 605             


Phe Val Ser Leu Arg Gly Ala Ser Glu Arg Thr Ala Leu Ser Pro Pro 
    610                 615                 620                 


Cys Asp Cys Arg Lys Glu Glu Ala Ala Asn Gln Thr Ser Thr Thr Gly 
625                 630                 635                 640 


Ile Val Ile Gly Ile His Ile Gly Val Thr Cys Ile Ile Phe Cys Val 
                645                 650                 655     


Leu Phe Leu Leu Phe Gly Gln Arg Gly Arg Val Leu Leu Cys Lys Asp 
            660                 665                 670         


Val Glu Asn Gln Leu Ser Pro Pro Gln Gly Pro Arg Ser Gln Arg Asp 
        675                 680                 685             


Pro Gly Ile Leu Ala Leu Asn Gly Ala Arg Arg Gly Gln Arg Gly Gln 
    690                 695                 700                 


Leu Gly Arg Asp Glu Lys Arg Val Asp Met Lys Glu Leu Glu Gln Leu 
705                 710                 715                 720 


Phe Pro Pro Ala Ser Ala Ala Gly Gln Pro Asp Pro Arg Pro Thr Gln 
                725                 730                 735     


Asp Pro Ala Ala Pro Ala Pro Cys Glu Glu Thr Gln Leu Ser Val Leu 
            740                 745                 750         


Pro Leu Gln Gly Cys Gly Leu Met Glu Gly Lys Thr Thr Glu Ala Lys 
        755                 760                 765             


Thr Thr Glu Ala Thr Ala Pro Cys Ala Gly Leu Ala Ala Ala Pro Pro 
    770                 775                 780                 


Pro Pro Asp Gly Gly Pro Gly Leu Leu Ser Glu Gly Gln Ala Ser Arg 
785                 790                 795                 800 


Pro Ala Ala Ala Arg Val Thr Gln Pro Ala His Ser Glu Gln 
                805                 810                 


<210>  3160
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  3160

Met Asn Ser Phe Phe Gly Thr Pro Ala Ala Ser Trp Cys Leu Leu Glu 
1               5                   10                  15      


Ser Asp Val Ser Ser Ala Pro Asp Lys Glu Ala Gly Arg Glu Arg Arg 
            20                  25                  30          


Ala Leu Ser Val Gln Gln Arg Gly Gly Pro Ala Trp Ser Gly Ser Leu 
        35                  40                  45              


Glu Trp Ser Arg Gln Ser Ala Gly Asp Arg Arg Arg Leu Gly Leu Ser 
    50                  55                  60                  


Arg Gln Thr Ala Lys Ser Ser Trp Ser Arg Ser Arg Asp Arg Thr Cys 
65                  70                  75                  80  


Cys Cys Arg Arg Ala Trp Trp Ile Leu Val Pro Ala Ala Asp Arg Ala 
                85                  90                  95      


Arg Arg Glu Arg Phe Ile Met Asn Glu Lys Trp Asp Thr Asn Ser Ser 
            100                 105                 110         


Glu Asn Trp His Pro Ile Trp Asn Val Asn Asp Thr Lys His His Leu 
        115                 120                 125             


Tyr Ser Asp Ile Asn Ile Thr Tyr Val Asn Tyr Tyr Leu His Gln Pro 
    130                 135                 140                 


Gln Val Ala Ala Ile Phe Ile Ile Ser Tyr Phe Leu Ile Phe Phe Leu 
145                 150                 155                 160 


Cys Met Met Gly Asn Thr Val Val Cys Phe Ile Val Met Arg Asn Lys 
                165                 170                 175     


His Met His Thr Val Thr Asn Leu Phe Ile Leu Asn Leu Ala Ile Ser 
            180                 185                 190         


Asp Leu Leu Val Gly Ile Phe Cys Met Pro Ile Thr Leu Leu Asp Asn 
        195                 200                 205             


Ile Ile Ala Gly Trp Pro Phe Gly Asn Thr Met Cys Lys Ile Ser Gly 
    210                 215                 220                 


Leu Val Gln Gly Ile Ser Val Ala Ala Ser Val Phe Thr Leu Val Ala 
225                 230                 235                 240 


Ile Ala Val Asp Arg Phe Gln Cys Val Val Tyr Pro Phe Lys Pro Lys 
                245                 250                 255     


Leu Thr Ile Lys Thr Ala Phe Val Ile Ile Met Ile Ile Trp Val Leu 
            260                 265                 270         


Ala Ile Thr Ile Met Ser Pro Ser Ala Val Met Leu His Val Gln Glu 
        275                 280                 285             


Glu Lys Tyr Tyr Arg Val Arg Leu Asn Ser Gln Asn Lys Thr Ser Pro 
    290                 295                 300                 


Val Tyr Trp Cys Arg Glu Asp Trp Pro Asn Gln Glu Met Arg Lys Ile 
305                 310                 315                 320 


Tyr Thr Thr Val Leu Phe Ala Asn Ile Tyr Leu Ala Pro Leu Ser Leu 
                325                 330                 335     


Ile Val Ile Met Tyr Gly Arg Ile Gly Ile Ser Leu Phe Arg Ala Ala 
            340                 345                 350         


Val Pro His Thr Gly Arg Lys Asn Gln Glu Gln Trp His Val Val Ser 
        355                 360                 365             


Arg Lys Lys Gln Lys Ile Ile Lys Met Leu Leu Ile Val Ala Leu Leu 
    370                 375                 380                 


Phe Ile Leu Ser Trp Leu Pro Leu Trp Thr Leu Met Met Leu Ser Asp 
385                 390                 395                 400 


Tyr Ala Asp Leu Ser Pro Asn Glu Leu Gln Ile Ile Asn Ile Tyr Ile 
                405                 410                 415     


Tyr Pro Phe Ala His Trp Leu Ala Phe Gly Asn Ser Ser Val Asn Pro 
            420                 425                 430         


Ile Ile Tyr Gly Phe Phe Asn Glu Asn Phe Arg Arg Gly Phe Gln Glu 
        435                 440                 445             


Ala Phe Gln Leu Gln Leu Cys Gln Lys Arg Ala Lys Pro Met Glu Ala 
    450                 455                 460                 


Tyr Ala Leu Lys Ala Lys Ser His Val Leu Ile Asn Thr Ser Asn Gln 
465                 470                 475                 480 


Leu Val Gln Glu Ser Thr Phe Gln Asn Pro His Gly Glu Thr Leu Leu 
                485                 490                 495     


Tyr Arg Lys Ser Ala Glu Lys Pro Gln Gln Glu Leu Val Met Glu Glu 
            500                 505                 510         


Leu Lys Glu Thr Thr Asn Ser Ser Glu Ile 
        515                 520         


<210>  3161
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  3161

Met Ser Leu Leu Pro Arg Arg Ala Pro Pro Val Ser Met Arg Leu Leu 
1               5                   10                  15      


Ala Ala Ala Leu Leu Leu Leu Leu Leu Ala Leu Tyr Thr Ala Arg Val 
            20                  25                  30          


Asp Gly Ser Lys Cys Lys Cys Ser Arg Lys Gly Pro Lys Ile Arg Tyr 
        35                  40                  45              


Ser Asp Val Lys Lys Leu Glu Met Lys Pro Lys Tyr Pro His Cys Glu 
    50                  55                  60                  


Glu Lys Met Val Ile Ile Thr Thr Lys Ser Val Ser Arg Tyr Arg Gly 
65                  70                  75                  80  


Gln Glu His Cys Leu His Pro Lys Leu Gln Ser Thr Lys Arg Phe Ile 
                85                  90                  95      


Lys Trp Tyr Asn Ala Trp Asn Glu Lys Arg Arg Val Tyr Glu Glu 
            100                 105                 110     


<210>  3162
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  3162

Met Ala Ser Val Gly Glu Cys Pro Ala Pro Val Pro Val Lys Asp Lys 
1               5                   10                  15      


Lys Leu Leu Glu Val Lys Leu Gly Glu Leu Pro Ser Trp Ile Leu Met 
            20                  25                  30          


Arg Asp Phe Ser Pro Ser Gly Ile Phe Gly Ala Phe Gln Arg Gly Tyr 
        35                  40                  45              


Tyr Arg Tyr Tyr Asn Lys Tyr Ile Asn Val Lys Lys Gly Ser Ile Ser 
    50                  55                  60                  


Gly Ile Thr Met Val Leu Ala Cys Tyr Val Leu Phe Ser Tyr Ser Phe 
65                  70                  75                  80  


Ser Tyr Lys His Leu Lys His Glu Arg Leu Arg Lys Tyr His 
                85                  90                  


<210>  3163
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  3163

Met Leu Gln Ser Ile Ile Lys Asn Ile Trp Ile Pro Met Lys Pro Tyr 
1               5                   10                  15      


Tyr Thr Lys Val Tyr Gln Glu Ile Trp Ile Gly Met Gly Leu Met Gly 
            20                  25                  30          


Phe Ile Val Tyr Lys Ile Arg Ala Ala Asp Lys Arg Ser Lys Ala Leu 
        35                  40                  45              


Lys Ala Ser Ala Pro Ala Pro Gly His His 
    50                  55              


<210>  3164
<211>  616
<212>  PRT
<213>  Homo sapiens

<400>  3164

Met Gly Arg Ile Gly Ile Ser Cys Leu Phe Pro Ala Ser Trp His Phe 
1               5                   10                  15      


Ser Ile Ser Pro Val Gly Cys Pro Arg Ile Leu Asn Thr Asn Leu Arg 
            20                  25                  30          


Gln Ile Met Val Ile Ser Val Leu Ala Ala Ala Val Ser Leu Leu Tyr 
        35                  40                  45              


Phe Ser Val Val Ile Ile Arg Asn Lys Tyr Gly Arg Leu Thr Arg Asp 
    50                  55                  60                  


Lys Lys Phe Gln Arg Tyr Leu Ala Arg Val Thr Asp Ile Glu Ala Thr 
65                  70                  75                  80  


Asp Thr Asn Asn Pro Asn Val Asn Tyr Gly Ile Val Val Asp Cys Gly 
                85                  90                  95      


Ser Ser Gly Ser Arg Val Phe Val Tyr Cys Trp Pro Arg His Asn Gly 
            100                 105                 110         


Asn Pro His Asp Leu Leu Asp Ile Arg Gln Met Arg Asp Lys Asn Arg 
        115                 120                 125             


Lys Pro Val Val Met Lys Ile Lys Pro Gly Ile Ser Glu Phe Ala Thr 
    130                 135                 140                 


Ser Pro Glu Lys Val Ser Asp Tyr Ile Ser Pro Leu Leu Asn Phe Ala 
145                 150                 155                 160 


Ala Glu His Val Pro Arg Ala Lys His Lys Glu Thr Pro Leu Tyr Ile 
                165                 170                 175     


Leu Cys Thr Ala Gly Met Arg Ile Leu Pro Glu Ser Gln Gln Lys Ala 
            180                 185                 190         


Ile Leu Glu Asp Leu Leu Thr Asp Ile Pro Val His Phe Asp Phe Leu 
        195                 200                 205             


Phe Ser Asp Ser His Ala Glu Val Ile Ser Gly Lys Gln Glu Gly Val 
    210                 215                 220                 


Tyr Ala Trp Ile Gly Ile Asn Phe Val Leu Gly Arg Phe Glu His Ile 
225                 230                 235                 240 


Glu Asp Asp Asp Glu Ala Val Val Glu Val Asn Ile Pro Gly Ser Glu 
                245                 250                 255     


Ser Ser Glu Ala Ile Val Arg Lys Arg Thr Ala Gly Ile Leu Asp Met 
            260                 265                 270         


Gly Gly Val Ser Thr Gln Ile Ala Tyr Glu Val Pro Lys Thr Val Ser 
        275                 280                 285             


Phe Ala Ser Ser Gln Gln Glu Glu Val Ala Lys Asn Leu Leu Ala Glu 
    290                 295                 300                 


Phe Asn Leu Gly Cys Asp Val His Gln Thr Glu His Val Tyr Arg Val 
305                 310                 315                 320 


Tyr Val Ala Thr Phe Leu Gly Phe Gly Gly Asn Ala Ala Arg Gln Arg 
                325                 330                 335     


Tyr Glu Asp Arg Ile Phe Ala Asn Thr Ile Gln Lys Asn Arg Leu Leu 
            340                 345                 350         


Gly Lys Gln Thr Gly Leu Thr Pro Asp Met Pro Tyr Leu Asp Pro Cys 
        355                 360                 365             


Leu Pro Leu Asp Ile Lys Asp Glu Ile Gln Gln Asn Gly Gln Thr Ile 
    370                 375                 380                 


Tyr Leu Arg Gly Thr Gly Asp Phe Asp Leu Cys Arg Glu Thr Ile Gln 
385                 390                 395                 400 


Pro Phe Met Asn Lys Thr Asn Glu Thr Gln Thr Ser Leu Asn Gly Val 
                405                 410                 415     


Tyr Gln Pro Pro Ile His Phe Gln Asn Ser Glu Phe Tyr Gly Phe Ser 
            420                 425                 430         


Glu Phe Tyr Tyr Cys Thr Glu Asp Val Leu Arg Met Gly Gly Asp Tyr 
        435                 440                 445             


Asn Ala Ala Lys Phe Thr Lys Ala Ala Lys Asp Tyr Cys Ala Thr Lys 
    450                 455                 460                 


Trp Ser Ile Leu Arg Glu Arg Phe Asp Arg Gly Leu Tyr Ala Ser His 
465                 470                 475                 480 


Ala Asp Leu His Arg Leu Lys Tyr Gln Cys Phe Lys Ser Ala Trp Met 
                485                 490                 495     


Phe Glu Val Phe His Arg Gly Phe Ser Phe Pro Val Asn Tyr Lys Ser 
            500                 505                 510         


Leu Lys Thr Ala Leu Gln Val Tyr Asp Lys Glu Val Gln Trp Thr Leu 
        515                 520                 525             


Gly Ala Ile Leu Tyr Arg Thr Arg Phe Leu Pro Leu Arg Asp Ile Gln 
    530                 535                 540                 


Gln Glu Ala Phe Arg Ala Ser His Thr His Trp Arg Gly Val Ser Phe 
545                 550                 555                 560 


Val Tyr Asn His Tyr Leu Phe Ser Gly Cys Phe Leu Val Val Leu Leu 
                565                 570                 575     


Ala Ile Leu Leu Tyr Leu Leu Arg Leu Arg Arg Ile His Arg Arg Thr 
            580                 585                 590         


Pro Arg Ser Ser Ser Ala Ala Ala Leu Trp Met Glu Glu Gly Leu Pro 
        595                 600                 605             


Ala Gln Asn Ala Pro Gly Thr Leu 
    610                 615     


<210>  3165
<211>  645
<212>  PRT
<213>  Homo sapiens

<400>  3165

Met Arg Pro Arg Lys Ala Phe Leu Leu Leu Leu Leu Leu Gly Leu Val 
1               5                   10                  15      


Gln Leu Leu Ala Val Ala Gly Ala Glu Gly Pro Asp Glu Asp Ser Ser 
            20                  25                  30          


Asn Arg Glu Asn Ala Ile Glu Asp Glu Glu Glu Glu Glu Glu Glu Asp 
        35                  40                  45              


Asp Asp Glu Glu Glu Asp Asp Leu Glu Val Lys Glu Glu Asn Gly Val 
    50                  55                  60                  


Leu Val Leu Asn Asp Ala Asn Phe Asp Asn Phe Val Ala Asp Lys Asp 
65                  70                  75                  80  


Thr Val Leu Leu Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Gln 
                85                  90                  95      


Phe Ala Pro Glu Tyr Glu Lys Ile Ala Asn Ile Leu Lys Asp Lys Asp 
            100                 105                 110         


Pro Pro Ile Pro Val Ala Lys Ile Asp Ala Thr Ser Ala Ser Val Leu 
        115                 120                 125             


Ala Ser Arg Phe Asp Val Ser Gly Tyr Pro Thr Ile Lys Ile Leu Lys 
    130                 135                 140                 


Lys Gly Gln Ala Val Asp Tyr Glu Gly Ser Arg Thr Gln Glu Glu Ile 
145                 150                 155                 160 


Val Ala Lys Val Arg Glu Val Ser Gln Pro Asp Trp Thr Pro Pro Pro 
                165                 170                 175     


Glu Val Thr Leu Val Leu Thr Lys Glu Asn Phe Asp Glu Val Val Asn 
            180                 185                 190         


Asp Ala Asp Ile Ile Leu Val Glu Phe Tyr Ala Pro Trp Cys Gly His 
        195                 200                 205             


Cys Lys Lys Leu Ala Pro Glu Tyr Glu Lys Ala Ala Lys Glu Leu Ser 
    210                 215                 220                 


Lys Arg Ser Pro Pro Ile Pro Leu Ala Lys Val Asp Ala Thr Ala Glu 
225                 230                 235                 240 


Thr Asp Leu Ala Lys Arg Phe Asp Val Ser Gly Tyr Pro Thr Leu Lys 
                245                 250                 255     


Ile Phe Arg Lys Gly Arg Pro Tyr Asp Tyr Asn Gly Pro Arg Glu Lys 
            260                 265                 270         


Tyr Gly Ile Val Asp Tyr Met Ile Glu Gln Ser Gly Pro Pro Ser Lys 
        275                 280                 285             


Glu Ile Leu Thr Leu Lys Gln Val Gln Glu Phe Leu Lys Asp Gly Asp 
    290                 295                 300                 


Asp Val Ile Ile Ile Gly Val Phe Lys Gly Glu Ser Asp Pro Ala Tyr 
305                 310                 315                 320 


Gln Gln Tyr Gln Asp Ala Ala Asn Asn Leu Arg Glu Asp Tyr Lys Phe 
                325                 330                 335     


His His Thr Phe Ser Thr Glu Ile Ala Lys Phe Leu Lys Val Ser Gln 
            340                 345                 350         


Gly Gln Leu Val Val Met Gln Pro Glu Lys Phe Gln Ser Lys Tyr Glu 
        355                 360                 365             


Pro Arg Ser His Met Met Asp Val Gln Gly Ser Thr Gln Asp Ser Ala 
    370                 375                 380                 


Ile Lys Asp Phe Val Leu Lys Tyr Ala Leu Pro Leu Val Gly His Arg 
385                 390                 395                 400 


Lys Val Ser Asn Asp Ala Lys Arg Tyr Thr Arg Arg Pro Leu Val Val 
                405                 410                 415     


Val Tyr Tyr Ser Val Asp Phe Ser Phe Asp Tyr Arg Ala Ala Thr Gln 
            420                 425                 430         


Phe Trp Arg Ser Lys Val Leu Glu Val Ala Lys Asp Phe Pro Glu Tyr 
        435                 440                 445             


Thr Phe Ala Ile Ala Asp Glu Glu Asp Tyr Ala Gly Glu Val Lys Asp 
    450                 455                 460                 


Leu Gly Leu Ser Glu Ser Gly Glu Asp Val Asn Ala Ala Ile Leu Asp 
465                 470                 475                 480 


Glu Ser Gly Lys Lys Phe Ala Met Glu Pro Glu Glu Phe Asp Ser Asp 
                485                 490                 495     


Thr Leu Arg Glu Phe Val Thr Ala Phe Lys Lys Gly Lys Leu Lys Pro 
            500                 505                 510         


Val Ile Lys Ser Gln Pro Val Pro Lys Asn Asn Lys Gly Pro Val Lys 
        515                 520                 525             


Val Val Val Gly Lys Thr Phe Asp Ser Ile Val Met Asp Pro Lys Lys 
    530                 535                 540                 


Asp Val Leu Ile Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Gln 
545                 550                 555                 560 


Leu Glu Pro Val Tyr Asn Ser Leu Ala Lys Lys Tyr Lys Gly Gln Lys 
                565                 570                 575     


Gly Leu Val Ile Ala Lys Met Asp Ala Thr Ala Asn Asp Val Pro Ser 
            580                 585                 590         


Asp Arg Tyr Lys Val Glu Gly Phe Pro Thr Ile Tyr Phe Ala Pro Ser 
        595                 600                 605             


Gly Asp Lys Lys Asn Pro Val Lys Phe Glu Gly Gly Asp Arg Asp Leu 
    610                 615                 620                 


Glu His Leu Ser Lys Phe Ile Glu Glu His Ala Thr Lys Leu Ser Arg 
625                 630                 635                 640 


Thr Lys Glu Glu Leu 
                645 


<210>  3166
<211>  678
<212>  PRT
<213>  Homo sapiens

<400>  3166

Met Ala Cys Leu Met Ala Ala Phe Ser Val Gly Thr Ala Met Asn Ala 
1               5                   10                  15      


Ser Ser Tyr Ser Ala Glu Met Thr Glu Pro Lys Ser Val Cys Val Ser 
            20                  25                  30          


Val Asp Glu Val Val Ser Ser Asn Met Glu Ala Thr Glu Thr Asp Leu 
        35                  40                  45              


Leu Asn Gly His Leu Lys Lys Val Asp Asn Asn Leu Thr Glu Ala Gln 
    50                  55                  60                  


Arg Phe Ser Ser Leu Pro Arg Arg Ala Ala Val Asn Ile Glu Phe Arg 
65                  70                  75                  80  


Asp Leu Ser Tyr Ser Val Pro Glu Gly Pro Trp Trp Arg Lys Lys Gly 
                85                  90                  95      


Tyr Lys Thr Leu Leu Lys Gly Ile Ser Gly Lys Phe Asn Ser Gly Glu 
            100                 105                 110         


Leu Val Ala Ile Met Gly Pro Ser Gly Ala Gly Lys Ser Thr Leu Met 
        115                 120                 125             


Asn Ile Leu Ala Gly Tyr Arg Glu Thr Gly Met Lys Gly Ala Val Leu 
    130                 135                 140                 


Ile Asn Gly Leu Pro Arg Asp Leu Arg Cys Phe Arg Lys Val Ser Cys 
145                 150                 155                 160 


Tyr Ile Met Gln Asp Asp Met Leu Leu Pro His Leu Thr Val Gln Glu 
                165                 170                 175     


Ala Met Met Val Ser Ala His Leu Lys Leu Gln Glu Lys Asp Glu Gly 
            180                 185                 190         


Arg Arg Glu Met Val Lys Glu Ile Leu Thr Ala Leu Gly Leu Leu Ser 
        195                 200                 205             


Cys Ala Asn Thr Arg Thr Gly Ser Leu Ser Gly Gly Gln Arg Lys Arg 
    210                 215                 220                 


Leu Ala Ile Ala Leu Glu Leu Val Asn Asn Pro Pro Val Met Phe Phe 
225                 230                 235                 240 


Asp Glu Pro Thr Ser Gly Leu Asp Ser Ala Ser Cys Phe Gln Val Val 
                245                 250                 255     


Ser Leu Met Lys Gly Leu Ala Gln Gly Gly Arg Ser Ile Ile Cys Thr 
            260                 265                 270         


Ile His Gln Pro Ser Ala Lys Leu Phe Glu Leu Phe Asp Gln Leu Tyr 
        275                 280                 285             


Val Leu Ser Gln Gly Gln Cys Val Tyr Arg Gly Lys Val Cys Asn Leu 
    290                 295                 300                 


Val Pro Tyr Leu Arg Asp Leu Gly Leu Asn Cys Pro Thr Tyr His Asn 
305                 310                 315                 320 


Pro Ala Asp Phe Val Met Glu Val Ala Ser Gly Glu Tyr Gly Asp Gln 
                325                 330                 335     


Asn Ser Arg Leu Val Arg Ala Val Arg Glu Gly Met Cys Asp Ser Asp 
            340                 345                 350         


His Lys Arg Asp Leu Gly Gly Asp Ala Glu Val Asn Pro Phe Leu Trp 
        355                 360                 365             


His Arg Pro Ser Glu Glu Val Lys Gln Thr Lys Arg Leu Lys Gly Leu 
    370                 375                 380                 


Arg Lys Asp Ser Ser Ser Met Glu Gly Cys His Ser Phe Ser Ala Ser 
385                 390                 395                 400 


Cys Leu Thr Gln Phe Cys Ile Leu Phe Lys Arg Thr Phe Leu Ser Ile 
                405                 410                 415     


Met Arg Asp Ser Val Leu Thr His Leu Arg Ile Thr Ser His Ile Gly 
            420                 425                 430         


Ile Gly Leu Leu Ile Gly Leu Leu Tyr Leu Gly Ile Gly Asn Glu Ala 
        435                 440                 445             


Lys Lys Val Leu Ser Asn Ser Gly Phe Leu Phe Phe Ser Met Leu Phe 
    450                 455                 460                 


Leu Met Phe Ala Ala Leu Met Pro Thr Val Leu Thr Phe Pro Leu Glu 
465                 470                 475                 480 


Met Gly Val Phe Leu Arg Glu His Leu Asn Tyr Trp Tyr Ser Leu Lys 
                485                 490                 495     


Ala Tyr Tyr Leu Ala Lys Thr Met Ala Asp Val Pro Phe Gln Ile Met 
            500                 505                 510         


Phe Pro Val Ala Tyr Cys Ser Ile Val Tyr Trp Met Thr Ser Gln Pro 
        515                 520                 525             


Ser Asp Ala Val Arg Phe Val Leu Phe Ala Ala Leu Gly Thr Met Thr 
    530                 535                 540                 


Ser Leu Val Ala Gln Ser Leu Gly Leu Leu Ile Gly Ala Ala Ser Thr 
545                 550                 555                 560 


Ser Leu Gln Val Ala Thr Phe Val Gly Pro Val Thr Ala Ile Pro Val 
                565                 570                 575     


Leu Leu Phe Ser Gly Phe Phe Val Ser Phe Asp Thr Ile Pro Thr Tyr 
            580                 585                 590         


Leu Gln Trp Met Ser Tyr Ile Ser Tyr Val Arg Tyr Gly Phe Glu Gly 
        595                 600                 605             


Val Ile Leu Ser Ile Tyr Gly Leu Asp Arg Glu Asp Leu His Cys Asp 
    610                 615                 620                 


Ile Asp Glu Thr Cys His Phe Gln Lys Ser Glu Ala Ile Leu Arg Glu 
625                 630                 635                 640 


Leu Asp Val Glu Asn Ala Lys Leu Tyr Leu Asp Phe Ile Val Leu Gly 
                645                 650                 655     


Ile Phe Phe Ile Ser Leu Arg Leu Ile Ala Tyr Phe Val Leu Arg Tyr 
            660                 665                 670         


Lys Ile Arg Ala Glu Arg 
        675             


<210>  3167
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  3167

Met Ala Thr Ala Gly Asn Pro Trp Gly Trp Phe Leu Gly Tyr Leu Ile 
1               5                   10                  15      


Leu Gly Val Ala Gly Ser Leu Val Ser Gly Ser Cys Ser Gln Ile Ile 
            20                  25                  30          


Asn Gly Glu Asp Cys Ser Pro His Ser Gln Pro Trp Gln Ala Ala Leu 
        35                  40                  45              


Val Met Glu Asn Glu Leu Phe Cys Ser Gly Val Leu Val His Pro Gln 
    50                  55                  60                  


Trp Val Leu Ser Ala Ala His Cys Phe Gln Asn Ser Tyr Thr Ile Gly 
65                  70                  75                  80  


Leu Gly Leu His Ser Leu Glu Ala Asp Gln Glu Pro Gly Ser Gln Met 
                85                  90                  95      


Val Glu Ala Ser Leu Ser Val Arg His Pro Glu Tyr Asn Arg Pro Leu 
            100                 105                 110         


Leu Ala Asn Asp Leu Met Leu Ile Lys Leu Asp Glu Ser Val Ser Glu 
        115                 120                 125             


Ser Asp Thr Ile Arg Ser Ile Ser Ile Ala Ser Gln Cys Pro Thr Ala 
    130                 135                 140                 


Gly Asn Ser Cys Leu Val Ser Gly Trp Gly Leu Leu Ala Asn Gly Arg 
145                 150                 155                 160 


Met Pro Thr Val Leu Gln Cys Val Asn Val Ser Val Val Ser Glu Glu 
                165                 170                 175     


Val Cys Ser Lys Leu Tyr Asp Pro Leu Tyr His Pro Ser Met Phe Cys 
            180                 185                 190         


Ala Gly Gly Gly Gln Asp Gln Lys Asp Ser Cys Asn Gly Asp Ser Gly 
        195                 200                 205             


Gly Pro Leu Ile Cys Asn Gly Tyr Leu Gln Gly Leu Val Ser Phe Gly 
    210                 215                 220                 


Lys Ala Pro Cys Gly Gln Val Gly Val Pro Gly Val Tyr Thr Asn Leu 
225                 230                 235                 240 


Cys Lys Phe Thr Glu Trp Ile Glu Lys Thr Val Gln Ala Ser 
                245                 250                 


<210>  3168
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  3168

Met Gly Arg Gln Lys Glu Leu Val Ser Arg Cys Gly Glu Met Leu His 
1               5                   10                  15      


Ile Arg Tyr Arg Leu Leu Arg Gln Ala Leu Ala Glu Cys Leu Gly Thr 
            20                  25                  30          


Leu Ile Leu Val Met Phe Gly Cys Gly Ser Val Ala Gln Val Val Leu 
        35                  40                  45              


Ser Arg Gly Thr His Gly Gly Phe Leu Thr Ile Asn Leu Ala Phe Gly 
    50                  55                  60                  


Phe Ala Val Thr Leu Gly Ile Leu Ile Ala Gly Gln Val Ser Gly Ala 
65                  70                  75                  80  


His Leu Asn Pro Ala Val Thr Phe Ala Met Cys Phe Leu Ala Arg Glu 
                85                  90                  95      


Pro Trp Ile Lys Leu Pro Ile Tyr Thr Leu Ala Gln Thr Leu Gly Ala 
            100                 105                 110         


Phe Leu Gly Ala Gly Ile Val Phe Gly Leu Tyr Tyr Asp Ala Ile Trp 
        115                 120                 125             


His Phe Ala Asp Asn Gln Leu Phe Val Ser Gly Pro Asn Gly Thr Ala 
    130                 135                 140                 


Gly Ile Phe Ala Thr Tyr Pro Ser Gly His Leu Asp Met Ile Asn Gly 
145                 150                 155                 160 


Phe Phe Asp Gln Phe Ile Gly Thr Ala Ser Leu Ile Val Cys Val Leu 
                165                 170                 175     


Ala Ile Val Asp Pro Tyr Asn Asn Pro Val Pro Arg Gly Leu Glu Ala 
            180                 185                 190         


Phe Thr Val Gly Leu Val Val Leu Val Ile Gly Thr Ser Met Gly Phe 
        195                 200                 205             


Asn Ser Gly Tyr Ala Val Asn Pro Ala Arg Asp Phe Gly Pro Arg Leu 
    210                 215                 220                 


Phe Thr Ala Leu Ala Gly Trp Gly Ser Ala Val Phe Thr Thr Gly Gln 
225                 230                 235                 240 


His Trp Trp Trp Val Pro Ile Val Ser Pro Leu Leu Gly Ser Ile Ala 
                245                 250                 255     


Gly Val Phe Val Tyr Gln Leu Met Ile Gly Cys His Leu Glu Gln Pro 
            260                 265                 270         


Pro Pro Ser Asn Glu Glu Glu Asn Val Lys Leu Ala His Val Lys His 
        275                 280                 285             


Lys Glu Gln Ile 
    290         


<210>  3169
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  3169

Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Thr Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro 
    130                 135                 140                 


Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Thr Gln Lys Gly Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu 
                165                 170                 175     


Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Ile His 
            180                 185                 190         


Leu Cys Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Phe 
        195                 200                 205             


Tyr Lys 
    210 


<210>  3170
<211>  790
<212>  PRT
<213>  Homo sapiens

<400>  3170

Met Arg Thr Tyr Arg Tyr Phe Leu Leu Leu Phe Trp Val Gly Gln Pro 
1               5                   10                  15      


Tyr Pro Thr Leu Ser Thr Pro Leu Ser Lys Arg Thr Ser Gly Phe Pro 
            20                  25                  30          


Ala Lys Lys Arg Ala Leu Glu Leu Ser Gly Asn Ser Lys Asn Glu Leu 
        35                  40                  45              


Asn Arg Ser Lys Arg Ser Trp Met Trp Asn Gln Phe Phe Leu Leu Glu 
    50                  55                  60                  


Glu Tyr Thr Gly Ser Asp Tyr Gln Tyr Val Gly Lys Leu His Ser Asp 
65                  70                  75                  80  


Gln Asp Arg Gly Asp Gly Ser Leu Lys Tyr Ile Leu Ser Gly Asp Gly 
                85                  90                  95      


Ala Gly Asp Leu Phe Ile Ile Asn Glu Asn Thr Gly Asp Ile Gln Ala 
            100                 105                 110         


Thr Lys Arg Leu Asp Arg Glu Glu Lys Pro Val Tyr Ile Leu Arg Ala 
        115                 120                 125             


Gln Ala Ile Asn Arg Arg Thr Gly Arg Pro Val Glu Pro Glu Ser Glu 
    130                 135                 140                 


Phe Ile Ile Lys Ile His Asp Ile Asn Asp Asn Glu Pro Ile Phe Thr 
145                 150                 155                 160 


Lys Glu Val Tyr Thr Ala Thr Val Pro Glu Met Ser Asp Val Gly Thr 
                165                 170                 175     


Phe Val Val Gln Val Thr Ala Thr Asp Ala Asp Asp Pro Thr Tyr Gly 
            180                 185                 190         


Asn Ser Ala Lys Val Val Tyr Ser Ile Leu Gln Gly Gln Pro Tyr Phe 
        195                 200                 205             


Ser Val Glu Ser Glu Thr Gly Ile Ile Lys Thr Ala Leu Leu Asn Met 
    210                 215                 220                 


Asp Arg Glu Asn Arg Glu Gln Tyr Gln Val Val Ile Gln Ala Lys Asp 
225                 230                 235                 240 


Met Gly Gly Gln Met Gly Gly Leu Ser Gly Thr Thr Thr Val Asn Ile 
                245                 250                 255     


Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Arg Phe Pro Gln Ser Thr 
            260                 265                 270         


Tyr Gln Phe Lys Thr Pro Glu Ser Ser Pro Pro Gly Thr Pro Ile Gly 
        275                 280                 285             


Arg Ile Lys Ala Ser Asp Ala Asp Val Gly Glu Asn Ala Glu Ile Glu 
    290                 295                 300                 


Tyr Ser Ile Thr Asp Gly Glu Gly Leu Asp Met Phe Asp Val Ile Thr 
305                 310                 315                 320 


Asp Gln Glu Thr Gln Glu Gly Ile Ile Thr Val Lys Lys Leu Leu Asp 
                325                 330                 335     


Phe Glu Lys Lys Lys Val Tyr Thr Leu Lys Val Glu Ala Ser Asn Pro 
            340                 345                 350         


Tyr Val Glu Pro Arg Phe Leu Tyr Leu Gly Pro Phe Lys Asp Ser Ala 
        355                 360                 365             


Thr Val Arg Ile Val Val Glu Asp Val Asp Glu Pro Pro Val Phe Ser 
    370                 375                 380                 


Lys Leu Ala Tyr Ile Leu Gln Ile Arg Glu Asp Ala Gln Ile Asn Thr 
385                 390                 395                 400 


Thr Ile Gly Ser Val Thr Ala Gln Asp Pro Asp Ala Ala Arg Asn Pro 
                405                 410                 415     


Val Lys Tyr Ser Val Asp Arg His Thr Asp Met Asp Arg Ile Phe Asn 
            420                 425                 430         


Ile Asp Ser Gly Asn Gly Ser Ile Phe Thr Ser Lys Leu Leu Asp Arg 
        435                 440                 445             


Glu Thr Leu Leu Trp His Asn Ile Thr Val Ile Ala Thr Glu Ile Asn 
    450                 455                 460                 


Asn Pro Lys Gln Ser Ser Arg Val Pro Leu Tyr Ile Lys Val Leu Asp 
465                 470                 475                 480 


Val Asn Asp Asn Ala Pro Glu Phe Ala Glu Phe Tyr Glu Thr Phe Val 
                485                 490                 495     


Cys Glu Lys Ala Lys Ala Asp Gln Leu Ile Gln Thr Leu His Ala Val 
            500                 505                 510         


Asp Lys Asp Asp Pro Tyr Ser Gly His Gln Phe Ser Phe Ser Leu Ala 
        515                 520                 525             


Pro Glu Ala Ala Ser Gly Ser Asn Phe Thr Ile Gln Asp Asn Lys Asp 
    530                 535                 540                 


Asn Thr Ala Gly Ile Leu Thr Arg Lys Asn Gly Tyr Asn Arg His Glu 
545                 550                 555                 560 


Met Ser Thr Tyr Leu Leu Pro Val Val Ile Ser Asp Asn Asp Tyr Pro 
                565                 570                 575     


Val Gln Ser Ser Thr Gly Thr Val Thr Val Arg Val Cys Ala Cys Asp 
            580                 585                 590         


His His Gly Asn Met Gln Ser Cys His Ala Glu Ala Leu Ile His Pro 
        595                 600                 605             


Thr Gly Leu Ser Thr Gly Ala Leu Val Ala Ile Leu Leu Cys Ile Val 
    610                 615                 620                 


Ile Leu Leu Val Thr Val Val Leu Phe Ala Ala Leu Arg Arg Gln Arg 
625                 630                 635                 640 


Lys Lys Glu Pro Leu Ile Ile Ser Lys Glu Asp Ile Arg Asp Asn Ile 
                645                 650                 655     


Val Ser Tyr Asn Asp Glu Gly Gly Gly Glu Glu Asp Thr Gln Ala Phe 
            660                 665                 670         


Asp Ile Gly Thr Leu Arg Asn Pro Glu Ala Ile Glu Asp Asn Lys Leu 
        675                 680                 685             


Arg Arg Asp Ile Val Pro Glu Ala Leu Phe Leu Pro Arg Arg Thr Pro 
    690                 695                 700                 


Thr Ala Arg Asp Asn Thr Asp Val Arg Asp Phe Ile Asn Gln Arg Leu 
705                 710                 715                 720 


Lys Glu Asn Asp Thr Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Ala 
                725                 730                 735     


Thr Tyr Ala Tyr Glu Gly Thr Gly Ser Val Ala Asp Ser Leu Ser Ser 
            740                 745                 750         


Leu Glu Ser Val Thr Thr Asp Ala Asp Gln Asp Tyr Asp Tyr Leu Ser 
        755                 760                 765             


Asp Trp Gly Pro Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Val 
    770                 775                 780                 


Asp Ser Asp Lys Asp Ser 
785                 790 


<210>  3171
<211>  814
<212>  PRT
<213>  Homo sapiens

<400>  3171

Met Asp Ala Ala Phe Leu Leu Val Leu Gly Leu Leu Ala Gln Ser Leu 
1               5                   10                  15      


Cys Leu Ser Leu Gly Val Pro Gly Trp Arg Arg Pro Thr Thr Leu Tyr 
            20                  25                  30          


Pro Trp Arg Arg Ala Pro Ala Leu Ser Arg Val Arg Arg Ala Trp Val 
        35                  40                  45              


Ile Pro Pro Ile Ser Val Ser Glu Asn His Lys Arg Leu Pro Tyr Pro 
    50                  55                  60                  


Leu Val Gln Ile Lys Ser Asp Lys Gln Gln Leu Gly Ser Val Ile Tyr 
65                  70                  75                  80  


Ser Ile Gln Gly Pro Gly Val Asp Glu Glu Pro Arg Gly Val Phe Ser 
                85                  90                  95      


Ile Asp Lys Phe Thr Gly Lys Val Phe Leu Asn Ala Met Leu Asp Arg 
            100                 105                 110         


Glu Lys Thr Asp Arg Phe Arg Leu Arg Ala Phe Ala Leu Asp Leu Gly 
        115                 120                 125             


Gly Ser Thr Leu Glu Asp Pro Thr Asp Leu Glu Ile Val Val Val Asp 
    130                 135                 140                 


Gln Asn Asp Asn Arg Pro Ala Phe Leu Gln Glu Ala Phe Thr Gly Arg 
145                 150                 155                 160 


Val Leu Glu Gly Ala Val Pro Gly Thr Tyr Val Thr Arg Ala Glu Ala 
                165                 170                 175     


Thr Asp Ala Asp Asp Pro Glu Thr Asp Asn Ala Ala Leu Arg Phe Ser 
            180                 185                 190         


Ile Leu Gln Gln Gly Ser Pro Glu Leu Phe Ser Ile Asp Glu Leu Thr 
        195                 200                 205             


Gly Glu Ile Arg Thr Val Gln Val Gly Leu Asp Arg Glu Val Val Ala 
    210                 215                 220                 


Val Tyr Asn Leu Thr Leu Gln Val Ala Asp Met Ser Gly Asp Gly Leu 
225                 230                 235                 240 


Thr Ala Thr Ala Ser Ala Ile Ile Thr Leu Asp Asp Ile Asn Asp Asn 
                245                 250                 255     


Ala Pro Glu Phe Thr Arg Asp Glu Phe Phe Met Glu Ala Ile Glu Ala 
            260                 265                 270         


Val Ser Gly Val Asp Val Gly Arg Leu Glu Val Glu Asp Arg Asp Leu 
        275                 280                 285             


Pro Gly Ser Pro Asn Trp Val Ala Arg Phe Thr Ile Leu Glu Gly Asp 
    290                 295                 300                 


Pro Asp Gly Gln Phe Thr Ile Arg Thr Asp Pro Lys Thr Asn Glu Gly 
305                 310                 315                 320 


Val Leu Ser Ile Val Lys Ala Leu Asp Tyr Glu Ser Cys Glu His Tyr 
                325                 330                 335     


Glu Leu Lys Val Ser Val Gln Asn Glu Ala Pro Leu Gln Ala Ala Ala 
            340                 345                 350         


Leu Arg Ala Glu Arg Gly Gln Ala Lys Val Arg Val His Val Gln Asp 
        355                 360                 365             


Thr Asn Glu Pro Pro Val Phe Gln Glu Asn Pro Leu Arg Thr Ser Leu 
    370                 375                 380                 


Ala Glu Gly Ala Pro Pro Gly Thr Leu Val Ala Thr Phe Ser Ala Arg 
385                 390                 395                 400 


Asp Pro Asp Thr Glu Gln Leu Gln Arg Leu Ser Tyr Ser Lys Asp Tyr 
                405                 410                 415     


Asp Pro Glu Asp Trp Leu Gln Val Asp Ala Ala Thr Gly Arg Ile Gln 
            420                 425                 430         


Thr Gln His Val Leu Ser Pro Ala Ser Pro Phe Leu Lys Gly Gly Trp 
        435                 440                 445             


Tyr Arg Ala Ile Val Leu Ala Gln Asp Asp Ala Ser Gln Pro Arg Thr 
    450                 455                 460                 


Ala Thr Gly Thr Leu Ser Ile Glu Ile Leu Glu Val Asn Asp His Ala 
465                 470                 475                 480 


Pro Val Leu Ala Pro Pro Pro Pro Gly Ser Leu Cys Ser Glu Pro His 
                485                 490                 495     


Gln Gly Pro Gly Leu Leu Leu Gly Ala Thr Asp Glu Asp Leu Pro Pro 
            500                 505                 510         


His Gly Ala Pro Phe His Phe Gln Leu Ser Pro Arg Leu Pro Glu Leu 
        515                 520                 525             


Gly Arg Asn Trp Ser Leu Ser Gln Val Asn Val Ser His Ala Arg Leu 
    530                 535                 540                 


Arg Pro Arg His Gln Val Pro Glu Gly Leu His Arg Leu Ser Leu Leu 
545                 550                 555                 560 


Leu Arg Asp Ser Gly Gln Pro Pro Gln Gln Arg Glu Gln Pro Leu Asn 
                565                 570                 575     


Val Thr Val Cys Arg Cys Gly Lys Asp Gly Val Cys Leu Pro Gly Ala 
            580                 585                 590         


Ala Ala Leu Leu Ala Gly Gly Thr Gly Leu Ser Leu Gly Ala Leu Val 
        595                 600                 605             


Ile Val Leu Ala Ser Ala Leu Leu Leu Leu Val Leu Val Leu Leu Val 
    610                 615                 620                 


Ala Leu Arg Ala Arg Phe Trp Lys Gln Ser Arg Gly Lys Gly Leu Leu 
625                 630                 635                 640 


His Gly Pro Gln Asp Asp Leu Arg Asp Asn Val Leu Asn Tyr Asp Glu 
                645                 650                 655     


Gln Gly Gly Gly Glu Glu Asp Gln Asp Ala Tyr Asp Ile Ser Gln Leu 
            660                 665                 670         


Arg His Pro Thr Ala Leu Ser Leu Pro Leu Gly Pro Pro Pro Leu Arg 
        675                 680                 685             


Arg Asp Ala Pro Gln Gly Arg Leu His Pro Gln Pro Pro Arg Val Leu 
    690                 695                 700                 


Pro Thr Ser Pro Leu Asp Ile Ala Asp Phe Ile Asn Asp Gly Leu Glu 
705                 710                 715                 720 


Ala Ala Asp Ser Asp Pro Ser Val Pro Pro Tyr Asp Thr Ala Leu Ile 
                725                 730                 735     


Tyr Asp Tyr Glu Gly Asp Gly Ser Val Ala Gly Thr Leu Ser Ser Ile 
            740                 745                 750         


Leu Ser Ser Gln Gly Asp Glu Asp Gln Asp Tyr Asp Tyr Leu Arg Asp 
        755                 760                 765             


Trp Gly Pro Arg Phe Ala Arg Leu Ala Asp Met Tyr Gly His Pro Cys 
    770                 775                 780                 


Gly Leu Glu Tyr Gly Ala Arg Trp Asp His Gln Ala Arg Glu Gly Leu 
785                 790                 795                 800 


Ser Pro Gly Ala Leu Leu Pro Arg His Arg Gly Arg Thr Ala 
                805                 810                 


<210>  3172
<211>  790
<212>  PRT
<213>  Homo sapiens

<400>  3172

Met Lys Ile Thr Ser Thr Ser Cys Ile Cys Pro Val Leu Val Cys Leu 
1               5                   10                  15      


Cys Phe Val Gln Arg Cys Tyr Gly Thr Ala His His Ser Ser Ile Lys 
            20                  25                  30          


Val Met Arg Asn Gln Thr Lys His Ile Glu Gly Glu Thr Glu Val His 
        35                  40                  45              


His Arg Pro Lys Arg Gly Trp Val Trp Asn Gln Phe Phe Val Leu Glu 
    50                  55                  60                  


Glu His Met Gly Pro Asp Pro Gln Tyr Val Gly Lys Leu His Ser Asn 
65                  70                  75                  80  


Ser Asp Lys Gly Asp Gly Ser Val Lys Tyr Ile Leu Thr Gly Glu Gly 
                85                  90                  95      


Ala Gly Thr Ile Phe Ile Ile Asp Asp Thr Thr Gly Asp Ile His Ser 
            100                 105                 110         


Thr Lys Ser Leu Asp Arg Glu Gln Lys Thr His Tyr Val Leu His Ala 
        115                 120                 125             


Gln Ala Ile Asp Arg Arg Thr Asn Lys Pro Leu Glu Pro Glu Ser Glu 
    130                 135                 140                 


Phe Ile Ile Lys Val Gln Asp Ile Asn Asp Asn Ala Pro Lys Phe Thr 
145                 150                 155                 160 


Asp Gly Pro Tyr Ile Val Thr Val Pro Glu Met Ser Asp Met Gly Thr 
                165                 170                 175     


Ser Val Leu Gln Val Thr Ala Thr Asp Ala Asp Asp Pro Thr Tyr Gly 
            180                 185                 190         


Asn Ser Ala Arg Val Val Tyr Ser Ile Leu Gln Gly Gln Pro Tyr Phe 
        195                 200                 205             


Ser Val Asp Pro Lys Thr Gly Val Ile Arg Thr Ala Leu His Asn Met 
    210                 215                 220                 


Asp Arg Glu Ala Arg Glu His Tyr Ser Val Val Ile Gln Ala Lys Asp 
225                 230                 235                 240 


Met Ala Gly Gln Val Gly Gly Leu Ser Gly Ser Thr Thr Val Asn Ile 
                245                 250                 255     


Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Arg Phe Pro Gln Lys His 
            260                 265                 270         


Tyr Gln Leu Tyr Val Pro Glu Ser Ala Gln Val Gly Ser Ala Val Gly 
        275                 280                 285             


Lys Ile Lys Ala Asn Asp Ala Asp Thr Gly Ser Asn Ala Asp Met Thr 
    290                 295                 300                 


Tyr Ser Ile Ile Asn Gly Asp Gly Met Gly Ile Phe Ser Ile Ser Thr 
305                 310                 315                 320 


Asp Lys Glu Thr Arg Glu Gly Ile Leu Ser Leu Lys Lys Pro Leu Asn 
                325                 330                 335     


Tyr Glu Lys Lys Lys Ser Tyr Thr Leu Asn Ile Glu Gly Ala Asn Thr 
            340                 345                 350         


His Leu Asp Phe Arg Phe Ser His Leu Gly Pro Phe Lys Asp Ala Thr 
        355                 360                 365             


Met Leu Lys Ile Ile Val Gly Asp Val Asp Glu Pro Pro Leu Phe Ser 
    370                 375                 380                 


Met Pro Ser Tyr Leu Met Glu Val Tyr Glu Asn Ala Lys Ile Gly Thr 
385                 390                 395                 400 


Val Val Gly Thr Val Leu Ala Gln Asp Pro Asp Ser Thr Asn Ser Leu 
                405                 410                 415     


Val Arg Tyr Phe Ile Asn Tyr Asn Val Glu Asp Asp Arg Phe Phe Asn 
            420                 425                 430         


Ile Asp Ala Asn Thr Gly Thr Ile Arg Thr Thr Lys Val Leu Asp Arg 
        435                 440                 445             


Glu Glu Thr Pro Trp Tyr Asn Ile Thr Val Thr Ala Ser Glu Ile Asp 
    450                 455                 460                 


Asn Pro Asp Leu Leu Ser His Val Thr Val Gly Ile Arg Val Leu Asp 
465                 470                 475                 480 


Val Asn Asp Asn Pro Pro Glu Leu Ala Arg Glu Tyr Asp Ile Ile Val 
                485                 490                 495     


Cys Glu Asn Ser Lys Pro Gly Gln Val Ile His Thr Ile Ser Ala Thr 
            500                 505                 510         


Asp Lys Asp Asp Phe Ala Asn Gly Pro Arg Phe Asn Phe Phe Leu Asp 
        515                 520                 525             


Glu Arg Leu Pro Val Asn Pro Asn Phe Thr Leu Lys Asp Asn Glu Asp 
    530                 535                 540                 


Asn Thr Ala Ser Ile Leu Thr Arg Arg Arg Arg Phe Ser Arg Thr Val 
545                 550                 555                 560 


Gln Asp Val Tyr Tyr Leu Pro Ile Met Ile Ser Asp Gly Gly Ile Pro 
                565                 570                 575     


Ser Leu Ser Ser Ser Ser Thr Leu Thr Ile Arg Val Cys Ala Cys Glu 
            580                 585                 590         


Arg Asp Gly Arg Val Arg Thr Cys His Ala Glu Ala Phe Leu Ser Ser 
        595                 600                 605             


Ala Gly Leu Ser Thr Gly Ala Leu Ile Ala Ile Leu Leu Cys Val Leu 
    610                 615                 620                 


Ile Leu Leu Ala Ile Val Val Leu Phe Ile Thr Leu Arg Arg Ser Lys 
625                 630                 635                 640 


Lys Glu Pro Leu Ile Ile Ser Glu Glu Asp Val Arg Glu Asn Val Val 
                645                 650                 655     


Thr Tyr Asp Asp Glu Gly Gly Gly Glu Glu Asp Thr Glu Ala Phe Asp 
            660                 665                 670         


Ile Thr Ala Leu Arg Asn Pro Ser Ala Ala Glu Glu Leu Lys Tyr Arg 
        675                 680                 685             


Arg Asp Ile Arg Pro Glu Val Lys Leu Thr Pro Arg His Gln Thr Ser 
    690                 695                 700                 


Ser Thr Leu Glu Ser Ile Asp Val Gln Glu Phe Ile Lys Gln Arg Leu 
705                 710                 715                 720 


Ala Glu Ala Asp Leu Asp Pro Ser Val Pro Pro Tyr Asp Ser Leu Gln 
                725                 730                 735     


Thr Tyr Ala Tyr Glu Gly Gln Arg Ser Glu Ala Gly Ser Ile Ser Ser 
            740                 745                 750         


Leu Asp Ser Ala Thr Thr Gln Ser Asp Gln Asp Tyr His Tyr Leu Gly 
        755                 760                 765             


Asp Trp Gly Pro Glu Phe Lys Lys Leu Ala Glu Leu Tyr Gly Glu Ile 
    770                 775                 780                 


Glu Ser Glu Arg Thr Thr 
785                 790 


<210>  3173
<211>  367
<212>  PRT
<213>  Homo sapiens

<400>  3173

Met Ile Arg Asn Trp Leu Thr Ile Phe Ile Leu Phe Pro Leu Lys Leu 
1               5                   10                  15      


Val Glu Lys Cys Glu Ser Ser Val Ser Leu Thr Val Pro Pro Val Val 
            20                  25                  30          


Lys Leu Glu Asn Gly Ser Ser Thr Asn Val Ser Leu Thr Leu Arg Pro 
        35                  40                  45              


Pro Leu Asn Ala Thr Leu Val Ile Thr Phe Glu Ile Thr Phe Arg Ser 
    50                  55                  60                  


Lys Asn Ile Thr Ile Leu Glu Leu Pro Asp Glu Val Val Val Pro Pro 
65                  70                  75                  80  


Gly Val Thr Asn Ser Ser Phe Gln Val Thr Ser Gln Asn Val Gly Gln 
                85                  90                  95      


Leu Thr Val Tyr Leu His Gly Asn His Ser Asn Gln Thr Gly Pro Arg 
            100                 105                 110         


Ile Arg Phe Leu Val Ile Arg Ser Ser Ala Ile Ser Ile Ile Asn Gln 
        115                 120                 125             


Val Ile Gly Trp Ile Tyr Phe Val Ala Trp Ser Ile Ser Phe Tyr Pro 
    130                 135                 140                 


Gln Val Ile Met Asn Trp Arg Arg Lys Ser Val Ile Gly Leu Ser Phe 
145                 150                 155                 160 


Asp Phe Val Ala Leu Asn Leu Thr Gly Phe Val Ala Tyr Ser Val Phe 
                165                 170                 175     


Asn Ile Gly Leu Leu Trp Val Pro Tyr Ile Lys Glu Gln Phe Leu Leu 
            180                 185                 190         


Lys Tyr Pro Asn Gly Val Asn Pro Val Asn Ser Asn Asp Val Phe Phe 
        195                 200                 205             


Ser Leu His Ala Val Val Leu Thr Leu Ile Ile Ile Val Gln Cys Cys 
    210                 215                 220                 


Leu Tyr Glu Arg Gly Gly Gln Arg Val Ser Trp Pro Ala Ile Gly Phe 
225                 230                 235                 240 


Leu Val Leu Ala Trp Leu Phe Ala Phe Val Thr Met Ile Val Ala Ala 
                245                 250                 255     


Val Gly Val Thr Thr Trp Leu Gln Phe Leu Phe Cys Phe Ser Tyr Ile 
            260                 265                 270         


Lys Leu Ala Val Thr Leu Val Lys Tyr Phe Pro Gln Ala Tyr Met Asn 
        275                 280                 285             


Phe Tyr Tyr Lys Ser Thr Glu Gly Trp Ser Ile Gly Asn Val Leu Leu 
    290                 295                 300                 


Asp Phe Thr Gly Gly Ser Phe Ser Leu Leu Gln Met Phe Leu Gln Ser 
305                 310                 315                 320 


Tyr Asn Asn Asp Gln Trp Thr Leu Ile Phe Gly Asp Pro Thr Lys Phe 
                325                 330                 335     


Gly Leu Gly Val Phe Ser Ile Val Phe Asp Val Val Phe Phe Ile Gln 
            340                 345                 350         


His Phe Cys Leu Tyr Arg Lys Arg Pro Gly Tyr Asp Gln Leu Asn 
        355                 360                 365         


<210>  3174
<211>  840
<212>  PRT
<213>  Homo sapiens

<400>  3174

Met Ala Leu Ala Ser Ala Ala Pro Gly Ser Ile Phe Cys Lys Gln Leu 
1               5                   10                  15      


Leu Phe Ser Leu Leu Val Leu Thr Leu Leu Cys Asp Ala Cys Gln Lys 
            20                  25                  30          


Val Tyr Leu Arg Val Pro Ser His Leu Gln Ala Glu Thr Leu Val Gly 
        35                  40                  45              


Lys Val Asn Leu Glu Glu Cys Leu Lys Ser Ala Ser Leu Ile Arg Ser 
    50                  55                  60                  


Ser Asp Pro Ala Phe Arg Ile Leu Glu Asp Gly Ser Ile Tyr Thr Thr 
65                  70                  75                  80  


His Asp Leu Ile Leu Ser Ser Glu Arg Lys Ser Phe Ser Ile Phe Leu 
                85                  90                  95      


Ser Asp Gly Gln Arg Arg Glu Gln Gln Glu Ile Lys Val Val Leu Ser 
            100                 105                 110         


Ala Arg Glu Asn Lys Ser Pro Lys Lys Arg His Thr Lys Asp Thr Ala 
        115                 120                 125             


Leu Lys Arg Ser Lys Arg Arg Trp Ala Pro Ile Pro Ala Ser Leu Met 
    130                 135                 140                 


Glu Asn Ser Leu Gly Pro Phe Pro Gln His Val Gln Gln Ile Gln Ser 
145                 150                 155                 160 


Asp Ala Ala Gln Asn Tyr Thr Ile Phe Tyr Ser Ile Ser Gly Pro Gly 
                165                 170                 175     


Val Asp Lys Glu Pro Phe Asn Leu Phe Tyr Ile Glu Lys Asp Thr Gly 
            180                 185                 190         


Asp Ile Phe Cys Thr Arg Ser Ile Asp Arg Glu Lys Tyr Glu Gln Phe 
        195                 200                 205             


Ala Leu Tyr Gly Tyr Ala Thr Thr Ala Asp Gly Tyr Ala Pro Glu Tyr 
    210                 215                 220                 


Pro Leu Pro Leu Ile Ile Lys Ile Glu Asp Asp Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Tyr Phe Glu His Arg Val Thr Ile Phe Thr Val Pro Glu Asn Cys Arg 
                245                 250                 255     


Ser Gly Thr Ser Val Gly Lys Val Thr Ala Thr Asp Leu Asp Glu Pro 
            260                 265                 270         


Asp Thr Leu His Thr Arg Leu Lys Tyr Lys Ile Leu Gln Gln Ile Pro 
        275                 280                 285             


Asp His Pro Lys His Phe Ser Ile His Pro Asp Thr Gly Val Ile Thr 
    290                 295                 300                 


Thr Thr Thr Pro Phe Leu Asp Arg Glu Lys Cys Asp Thr Tyr Gln Leu 
305                 310                 315                 320 


Ile Met Glu Val Arg Asp Met Gly Gly Gln Pro Phe Gly Leu Phe Asn 
                325                 330                 335     


Thr Gly Thr Ile Thr Ile Ser Leu Glu Asp Glu Asn Asp Asn Pro Pro 
            340                 345                 350         


Ser Phe Thr Glu Thr Ser Tyr Val Thr Glu Val Glu Glu Asn Arg Ile 
        355                 360                 365             


Asp Val Glu Ile Leu Arg Met Lys Val Gln Asp Gln Asp Leu Pro Asn 
    370                 375                 380                 


Thr Pro His Ser Lys Ala Val Tyr Lys Ile Leu Gln Gly Asn Glu Asn 
385                 390                 395                 400 


Gly Asn Phe Ile Ile Ser Thr Asp Pro Asn Thr Asn Glu Gly Val Leu 
                405                 410                 415     


Cys Val Val Lys Pro Leu Asn Tyr Glu Val Asn Arg Gln Val Ile Leu 
            420                 425                 430         


Gln Val Gly Val Ile Asn Glu Ala Gln Phe Ser Lys Ala Ala Ser Ser 
        435                 440                 445             


Gln Thr Pro Thr Met Cys Thr Thr Thr Val Thr Val Lys Ile Ile Asp 
    450                 455                 460                 


Ser Asp Glu Gly Pro Glu Cys His Pro Pro Val Lys Val Ile Gln Ser 
465                 470                 475                 480 


Gln Asp Gly Phe Pro Ala Gly Gln Glu Leu Leu Gly Tyr Lys Ala Leu 
                485                 490                 495     


Asp Pro Glu Ile Ser Ser Gly Glu Gly Leu Arg Tyr Gln Lys Leu Gly 
            500                 505                 510         


Asp Glu Asp Asn Trp Phe Glu Ile Asn Gln His Thr Gly Asp Leu Arg 
        515                 520                 525             


Thr Leu Lys Val Leu Asp Arg Glu Ser Lys Phe Val Lys Asn Asn Gln 
    530                 535                 540                 


Tyr Asn Ile Ser Val Val Ala Val Asp Ala Val Gly Arg Ser Cys Thr 
545                 550                 555                 560 


Gly Thr Leu Val Val His Leu Asp Asp Tyr Asn Asp His Ala Pro Gln 
                565                 570                 575     


Ile Asp Lys Glu Val Thr Ile Cys Gln Asn Asn Glu Asp Phe Ala Val 
            580                 585                 590         


Leu Lys Pro Val Asp Pro Asp Gly Pro Glu Asn Gly Pro Pro Phe Gln 
        595                 600                 605             


Phe Phe Leu Asp Asn Ser Ala Ser Lys Asn Trp Asn Ile Glu Glu Lys 
    610                 615                 620                 


Asp Gly Lys Thr Ala Ile Leu Arg Gln Arg Gln Asn Leu Asp Tyr Asn 
625                 630                 635                 640 


Tyr Tyr Ser Val Pro Ile Gln Ile Lys Asp Arg His Gly Leu Val Ala 
                645                 650                 655     


Thr His Met Leu Thr Val Arg Val Cys Asp Cys Ser Thr Pro Ser Glu 
            660                 665                 670         


Cys Arg Met Lys Asp Lys Ser Thr Arg Asp Val Arg Pro Asn Val Ile 
        675                 680                 685             


Leu Gly Arg Trp Ala Ile Leu Ala Met Val Leu Gly Ser Val Leu Leu 
    690                 695                 700                 


Leu Cys Ile Leu Phe Thr Cys Phe Cys Val Thr Ala Lys Arg Thr Val 
705                 710                 715                 720 


Lys Lys Cys Phe Pro Glu Asp Ile Ala Gln Gln Asn Leu Ile Val Ser 
                725                 730                 735     


Asn Thr Glu Gly Pro Gly Glu Glu Val Thr Glu Ala Asn Ile Arg Leu 
            740                 745                 750         


Pro Met Gln Thr Ser Asn Ile Cys Asp Thr Ser Met Ser Val Gly Thr 
        755                 760                 765             


Val Gly Gly Gln Gly Ile Lys Thr Gln Gln Ser Phe Glu Met Val Lys 
    770                 775                 780                 


Gly Gly Tyr Thr Leu Asp Ser Asn Lys Gly Gly Gly His Gln Thr Leu 
785                 790                 795                 800 


Glu Ser Val Lys Gly Val Gly Gln Gly Asp Thr Gly Arg Tyr Ala Tyr 
                805                 810                 815     


Thr Asp Trp Gln Ser Phe Thr Gln Pro Arg Leu Gly Glu Glu Ser Ile 
            820                 825                 830         


Arg Gly His Thr Leu Ile Lys Asn 
        835                 840 


<210>  3175
<211>  847
<212>  PRT
<213>  Homo sapiens

<400>  3175

Met Glu Ala Ala Arg Pro Ser Gly Ser Trp Asn Gly Ala Leu Cys Arg 
1               5                   10                  15      


Leu Leu Leu Leu Thr Leu Ala Ile Leu Ile Phe Ala Ser Asp Ala Cys 
            20                  25                  30          


Lys Asn Val Thr Leu His Val Pro Ser Lys Leu Asp Ala Glu Lys Leu 
        35                  40                  45              


Val Gly Arg Val Asn Leu Lys Glu Cys Phe Thr Ala Ala Asn Leu Ile 
    50                  55                  60                  


His Ser Ser Asp Pro Asp Phe Gln Ile Leu Glu Asp Gly Ser Val Tyr 
65                  70                  75                  80  


Thr Thr Asn Thr Ile Leu Leu Ser Ser Glu Lys Arg Ser Phe Thr Ile 
                85                  90                  95      


Leu Leu Ser Asn Thr Glu Asn Gln Glu Lys Lys Lys Ile Phe Val Phe 
            100                 105                 110         


Leu Glu His Gln Thr Lys Val Leu Lys Lys Arg His Thr Lys Glu Lys 
        115                 120                 125             


Val Leu Arg Arg Ala Lys Arg Arg Trp Ala Pro Ile Pro Cys Ser Met 
    130                 135                 140                 


Leu Glu Asn Ser Leu Gly Pro Phe Pro Leu Phe Leu Gln Gln Val Gln 
145                 150                 155                 160 


Ser Asp Thr Ala Gln Asn Tyr Thr Ile Tyr Tyr Ser Ile Arg Gly Pro 
                165                 170                 175     


Gly Val Asp Gln Glu Pro Arg Asn Leu Phe Tyr Val Glu Arg Asp Thr 
            180                 185                 190         


Gly Asn Leu Tyr Cys Thr Arg Pro Val Asp Arg Glu Gln Tyr Glu Ser 
        195                 200                 205             


Phe Glu Ile Ile Ala Phe Ala Thr Thr Pro Asp Gly Tyr Thr Pro Glu 
    210                 215                 220                 


Leu Pro Leu Pro Leu Ile Ile Lys Ile Glu Asp Glu Asn Asp Asn Tyr 
225                 230                 235                 240 


Pro Ile Phe Thr Glu Glu Thr Tyr Thr Phe Thr Ile Phe Glu Asn Cys 
                245                 250                 255     


Arg Val Gly Thr Thr Val Gly Gln Val Cys Ala Thr Asp Lys Asp Glu 
            260                 265                 270         


Pro Asp Thr Met His Thr Arg Leu Lys Tyr Ser Ile Ile Gly Gln Val 
        275                 280                 285             


Pro Pro Ser Pro Thr Leu Phe Ser Met His Pro Thr Thr Gly Val Ile 
    290                 295                 300                 


Thr Thr Thr Ser Ser Gln Leu Asp Arg Glu Leu Ile Asp Lys Tyr Gln 
305                 310                 315                 320 


Leu Lys Ile Lys Val Gln Asp Met Asp Gly Gln Tyr Phe Gly Leu Gln 
                325                 330                 335     


Thr Thr Ser Thr Cys Ile Ile Asn Ile Asp Asp Val Asn Asp His Leu 
            340                 345                 350         


Pro Thr Phe Thr Arg Thr Ser Tyr Val Thr Ser Val Glu Glu Asn Thr 
        355                 360                 365             


Val Asp Val Glu Ile Leu Arg Val Thr Val Glu Asp Lys Asp Leu Val 
    370                 375                 380                 


Asn Thr Ala Asn Trp Arg Ala Asn Tyr Thr Ile Leu Lys Gly Asn Glu 
385                 390                 395                 400 


Asn Gly Asn Phe Lys Ile Val Thr Asp Ala Lys Thr Asn Glu Gly Val 
                405                 410                 415     


Leu Cys Val Val Lys Pro Leu Asn Tyr Glu Glu Lys Gln Gln Met Ile 
            420                 425                 430         


Leu Gln Ile Gly Val Val Asn Glu Ala Pro Phe Ser Arg Glu Ala Ser 
        435                 440                 445             


Pro Arg Ser Ala Met Ser Thr Ala Thr Val Thr Val Asn Val Glu Asp 
    450                 455                 460                 


Gln Asp Glu Gly Pro Glu Cys Asn Pro Pro Ile Gln Thr Val Arg Met 
465                 470                 475                 480 


Lys Glu Asn Ala Glu Val Gly Thr Thr Ser Asn Gly Tyr Lys Ala Tyr 
                485                 490                 495     


Asp Pro Glu Thr Arg Ser Ser Ser Gly Ile Arg Tyr Lys Lys Leu Thr 
            500                 505                 510         


Asp Pro Thr Gly Trp Val Thr Ile Asp Glu Asn Thr Gly Ser Ile Lys 
        515                 520                 525             


Val Phe Arg Ser Leu Asp Arg Glu Ala Glu Thr Ile Lys Asn Gly Ile 
    530                 535                 540                 


Tyr Asn Ile Thr Val Leu Ala Ser Asp Gln Gly Gly Arg Thr Cys Thr 
545                 550                 555                 560 


Gly Thr Leu Gly Ile Ile Leu Gln Asp Val Asn Asp Asn Ser Pro Phe 
                565                 570                 575     


Ile Pro Lys Lys Thr Val Ile Ile Cys Lys Pro Thr Met Ser Ser Ala 
            580                 585                 590         


Glu Ile Val Ala Val Asp Pro Asp Glu Pro Ile His Gly Pro Pro Phe 
        595                 600                 605             


Asp Phe Ser Leu Glu Ser Ser Thr Ser Glu Val Gln Arg Met Trp Arg 
    610                 615                 620                 


Leu Lys Ala Ile Asn Asp Thr Ala Ala Arg Leu Ser Tyr Gln Asn Asp 
625                 630                 635                 640 


Pro Pro Phe Gly Ser Tyr Val Val Pro Ile Thr Val Arg Asp Arg Leu 
                645                 650                 655     


Gly Met Ser Ser Val Thr Ser Leu Asp Val Thr Leu Cys Asp Cys Ile 
            660                 665                 670         


Thr Glu Asn Asp Cys Thr His Arg Val Asp Pro Arg Ile Gly Gly Gly 
        675                 680                 685             


Gly Val Gln Leu Gly Lys Trp Ala Ile Leu Ala Ile Leu Leu Gly Ile 
    690                 695                 700                 


Ala Leu Leu Phe Cys Ile Leu Phe Thr Leu Val Cys Gly Ala Ser Gly 
705                 710                 715                 720 


Thr Ser Lys Gln Pro Lys Val Ile Pro Asp Asp Leu Ala Gln Gln Asn 
                725                 730                 735     


Leu Ile Val Ser Asn Thr Glu Ala Pro Gly Asp Asp Lys Val Tyr Ser 
            740                 745                 750         


Ala Asn Gly Phe Thr Thr Gln Thr Val Gly Ala Ser Ala Gln Gly Val 
        755                 760                 765             


Cys Gly Thr Val Gly Ser Gly Ile Lys Asn Gly Gly Gln Glu Thr Ile 
    770                 775                 780                 


Glu Met Val Lys Gly Gly His Gln Thr Ser Glu Ser Cys Arg Gly Ala 
785                 790                 795                 800 


Gly His His His Thr Leu Asp Ser Cys Arg Gly Gly His Thr Glu Val 
                805                 810                 815     


Asp Asn Cys Arg Tyr Thr Tyr Ser Glu Trp His Ser Phe Thr Gln Pro 
            820                 825                 830         


Arg Leu Gly Glu Glu Ser Ile Arg Gly His Thr Leu Ile Lys Asn 
        835                 840                 845         


<210>  3176
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  3176

Met Asp Ile Gln Met Ala Asn Asn Phe Thr Pro Pro Ser Ala Thr Pro 
1               5                   10                  15      


Gln Gly Asn Asp Cys Asp Leu Tyr Ala His His Ser Thr Ala Arg Ile 
            20                  25                  30          


Val Met Pro Leu His Tyr Ser Leu Val Phe Ile Ile Gly Leu Val Gly 
        35                  40                  45              


Asn Leu Leu Ala Leu Val Val Ile Val Gln Asn Arg Lys Lys Ile Asn 
    50                  55                  60                  


Ser Thr Thr Leu Tyr Ser Thr Asn Leu Val Ile Ser Asp Ile Leu Phe 
65                  70                  75                  80  


Thr Thr Ala Leu Pro Thr Arg Ile Ala Tyr Tyr Ala Met Gly Phe Asp 
                85                  90                  95      


Trp Arg Ile Gly Asp Ala Leu Cys Arg Ile Thr Ala Leu Val Phe Tyr 
            100                 105                 110         


Ile Asn Thr Tyr Ala Gly Val Asn Phe Met Thr Cys Leu Ser Ile Asp 
        115                 120                 125             


Arg Phe Ile Ala Val Val His Pro Leu Arg Tyr Asn Lys Ile Lys Arg 
    130                 135                 140                 


Ile Glu His Ala Lys Gly Val Cys Ile Phe Val Trp Ile Leu Val Phe 
145                 150                 155                 160 


Ala Gln Thr Leu Pro Leu Leu Ile Asn Pro Met Ser Lys Gln Glu Ala 
                165                 170                 175     


Glu Arg Ile Thr Cys Met Glu Tyr Pro Asn Phe Glu Glu Thr Lys Ser 
            180                 185                 190         


Leu Pro Trp Ile Leu Leu Gly Ala Cys Phe Ile Gly Tyr Val Leu Pro 
        195                 200                 205             


Leu Ile Ile Ile Leu Ile Cys Tyr Ser Gln Ile Cys Cys Lys Leu Phe 
    210                 215                 220                 


Arg Thr Ala Lys Gln Asn Pro Leu Thr Glu Lys Ser Gly Val Asn Lys 
225                 230                 235                 240 


Lys Ala Leu Asn Thr Ile Ile Leu Ile Ile Val Val Phe Val Leu Cys 
                245                 250                 255     


Phe Thr Pro Tyr His Val Ala Ile Ile Gln His Met Ile Lys Lys Leu 
            260                 265                 270         


Arg Phe Ser Asn Phe Leu Glu Cys Ser Gln Arg His Ser Phe Gln Ile 
        275                 280                 285             


Ser Leu His Phe Thr Val Cys Leu Met Asn Phe Asn Cys Cys Met Asp 
    290                 295                 300                 


Pro Phe Ile Tyr Phe Phe Ala Cys Lys Gly Tyr Lys Arg Lys Val Met 
305                 310                 315                 320 


Arg Met Leu Lys Arg Gln Val Ser Val Ser Ile Ser Ser Ala Val Lys 
                325                 330                 335     


Ser Ala Pro Glu Glu Asn Ser Arg Glu Met Thr Glu Thr Gln Met Met 
            340                 345                 350         


Ile His Ser Lys Ser Ser Asn Gly Lys 
        355                 360     


<210>  3177
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  3177

Met Thr Thr Ser His Gln Pro Gln Asp Arg Tyr Lys Ala Val Trp Leu 
1               5                   10                  15      


Ile Phe Phe Met Leu Gly Leu Gly Thr Leu Leu Pro Trp Asn Phe Phe 
            20                  25                  30          


Met Thr Ala Thr Gln Tyr Phe Thr Asn Arg Leu Asp Met Ser Gln Asn 
        35                  40                  45              


Val Ser Leu Val Thr Ala Glu Leu Ser Lys Asp Ala Gln Ala Ser Ala 
    50                  55                  60                  


Ala Pro Ala Ala Pro Leu Pro Glu Arg Asn Ser Leu Ser Ala Ile Phe 
65                  70                  75                  80  


Asn Asn Val Met Thr Leu Cys Ala Met Leu Pro Leu Leu Leu Phe Thr 
                85                  90                  95      


Tyr Leu Asn Ser Phe Leu His Gln Arg Ile Pro Gln Ser Val Arg Ile 
            100                 105                 110         


Leu Gly Ser Leu Val Ala Ile Leu Leu Val Phe Leu Ile Thr Ala Ile 
        115                 120                 125             


Leu Val Lys Val Gln Leu Asp Ala Leu Pro Phe Phe Val Ile Thr Met 
    130                 135                 140                 


Ile Lys Ile Val Leu Ile Asn Ser Phe Gly Ala Ile Leu Gln Gly Ser 
145                 150                 155                 160 


Leu Phe Gly Leu Ala Gly Leu Leu Pro Ala Ser Tyr Thr Ala Pro Ile 
                165                 170                 175     


Met Ser Gly Gln Gly Leu Ala Gly Phe Phe Ala Ser Val Ala Met Ile 
            180                 185                 190         


Cys Ala Ile Ala Ser Gly Ser Glu Leu Ser Glu Ser Ala Phe Gly Tyr 
        195                 200                 205             


Phe Ile Thr Ala Cys Ala Val Ile Ile Leu Thr Ile Ile Cys Tyr Leu 
    210                 215                 220                 


Gly Leu Pro Arg Leu Glu Phe Tyr Arg Tyr Tyr Gln Gln Leu Lys Leu 
225                 230                 235                 240 


Glu Gly Pro Gly Glu Gln Glu Thr Lys Leu Asp Leu Ile Ser Lys Gly 
                245                 250                 255     


Glu Glu Pro Arg Ala Gly Lys Glu Glu Ser Gly Val Ser Val Ser Asn 
            260                 265                 270         


Ser Gln Pro Thr Asn Glu Ser His Ser Ile Lys Ala Ile Leu Lys Asn 
        275                 280                 285             


Ile Ser Val Leu Ala Phe Ser Val Cys Phe Ile Phe Thr Ile Thr Ile 
    290                 295                 300                 


Gly Met Phe Pro Ala Val Thr Val Glu Val Lys Ser Ser Ile Ala Gly 
305                 310                 315                 320 


Ser Ser Thr Trp Glu Arg Tyr Phe Ile Pro Val Ser Cys Phe Leu Thr 
                325                 330                 335     


Phe Asn Ile Phe Asp Trp Leu Gly Arg Ser Leu Thr Ala Val Phe Met 
            340                 345                 350         


Trp Pro Gly Lys Asp Ser Arg Trp Leu Pro Ser Leu Val Leu Ala Arg 
        355                 360                 365             


Leu Val Phe Val Pro Leu Leu Leu Leu Cys Asn Ile Lys Pro Arg Arg 
    370                 375                 380                 


Tyr Leu Thr Val Val Phe Glu His Asp Ala Trp Phe Ile Phe Phe Met 
385                 390                 395                 400 


Ala Ala Phe Ala Phe Ser Asn Gly Tyr Leu Ala Ser Leu Cys Met Cys 
                405                 410                 415     


Phe Gly Pro Lys Lys Val Lys Pro Ala Glu Ala Glu Thr Ala Gly Ala 
            420                 425                 430         


Ile Met Ala Phe Phe Leu Cys Leu Gly Leu Ala Leu Gly Ala Val Phe 
        435                 440                 445             


Ser Phe Leu Phe Arg Ala Ile Val 
    450                 455     


<210>  3178
<211>  506
<212>  PRT
<213>  Homo sapiens

<400>  3178

Met Leu Ser Lys Val Leu Pro Val Leu Leu Gly Ile Leu Leu Ile Leu 
1               5                   10                  15      


Gln Ser Arg Val Glu Gly Pro Gln Thr Glu Ser Lys Asn Glu Ala Ser 
            20                  25                  30          


Ser Arg Asp Val Val Tyr Gly Pro Gln Pro Gln Pro Leu Glu Asn Gln 
        35                  40                  45              


Leu Leu Ser Glu Glu Thr Lys Ser Thr Glu Thr Glu Thr Gly Ser Arg 
    50                  55                  60                  


Val Gly Lys Leu Pro Glu Ala Ser Arg Ile Leu Asn Thr Ile Leu Ser 
65                  70                  75                  80  


Asn Tyr Asp His Lys Leu Arg Pro Gly Ile Gly Glu Lys Pro Thr Val 
                85                  90                  95      


Val Thr Val Glu Ile Ser Val Asn Ser Leu Gly Pro Leu Ser Ile Leu 
            100                 105                 110         


Asp Met Glu Tyr Thr Ile Asp Ile Ile Phe Ser Gln Thr Trp Tyr Asp 
        115                 120                 125             


Glu Arg Leu Cys Tyr Asn Asp Thr Phe Glu Ser Leu Val Leu Asn Gly 
    130                 135                 140                 


Asn Val Val Ser Gln Leu Trp Ile Pro Asp Thr Phe Phe Arg Asn Ser 
145                 150                 155                 160 


Lys Arg Thr His Glu His Glu Ile Thr Met Pro Asn Gln Met Val Arg 
                165                 170                 175     


Ile Tyr Lys Asp Gly Lys Val Leu Tyr Thr Ile Arg Met Thr Ile Asp 
            180                 185                 190         


Ala Gly Cys Ser Leu His Met Leu Arg Phe Pro Met Asp Ser His Ser 
        195                 200                 205             


Cys Pro Leu Ser Phe Ser Ser Phe Ser Tyr Pro Glu Asn Glu Met Ile 
    210                 215                 220                 


Tyr Lys Trp Glu Asn Phe Lys Leu Glu Ile Asn Glu Lys Asn Ser Trp 
225                 230                 235                 240 


Lys Leu Phe Gln Phe Asp Phe Thr Gly Val Ser Asn Lys Thr Glu Ile 
                245                 250                 255     


Ile Thr Thr Pro Val Gly Asp Phe Met Val Met Thr Ile Phe Phe Asn 
            260                 265                 270         


Val Ser Arg Arg Phe Gly Tyr Val Ala Phe Gln Asn Tyr Val Pro Ser 
        275                 280                 285             


Ser Val Thr Thr Met Leu Ser Trp Val Ser Phe Trp Ile Lys Thr Glu 
    290                 295                 300                 


Ser Ala Pro Ala Arg Thr Ser Leu Gly Ile Thr Ser Val Leu Thr Met 
305                 310                 315                 320 


Thr Thr Leu Gly Thr Phe Ser Arg Lys Asn Phe Pro Arg Val Ser Tyr 
                325                 330                 335     


Ile Thr Ala Leu Asp Phe Tyr Ile Ala Ile Cys Phe Val Phe Cys Phe 
            340                 345                 350         


Cys Ala Leu Leu Glu Phe Ala Val Leu Asn Phe Leu Ile Tyr Asn Gln 
        355                 360                 365             


Thr Lys Ala His Ala Ser Pro Lys Leu Arg His Pro Arg Ile Asn Ser 
    370                 375                 380                 


Arg Ala His Ala Arg Thr Arg Ala Arg Ser Arg Ala Cys Ala Arg Gln 
385                 390                 395                 400 


His Gln Glu Ala Phe Val Cys Gln Ile Val Thr Thr Glu Gly Ser Asp 
                405                 410                 415     


Gly Glu Glu Arg Pro Ser Cys Ser Ala Gln Gln Pro Pro Ser Pro Gly 
            420                 425                 430         


Ser Pro Glu Gly Pro Arg Ser Leu Cys Ser Lys Leu Ala Cys Cys Glu 
        435                 440                 445             


Trp Cys Lys Arg Phe Lys Lys Tyr Phe Cys Met Val Pro Asp Cys Glu 
    450                 455                 460                 


Gly Ser Thr Trp Gln Gln Gly Arg Leu Cys Ile His Val Tyr Arg Leu 
465                 470                 475                 480 


Asp Asn Tyr Ser Arg Val Val Phe Pro Val Thr Phe Phe Phe Phe Asn 
                485                 490                 495     


Val Leu Tyr Trp Leu Val Cys Leu Asn Leu 
            500                 505     


<210>  3179
<211>  1073
<212>  PRT
<213>  Homo sapiens

<400>  3179

Met Lys Thr Leu Leu Leu Asp Leu Ala Leu Trp Ser Leu Leu Phe Gln 
1               5                   10                  15      


Pro Gly Trp Leu Ser Phe Ser Ser Gln Val Ser Gln Asn Cys His Asn 
            20                  25                  30          


Gly Ser Tyr Glu Ile Ser Val Leu Met Met Gly Asn Ser Ala Phe Ala 
        35                  40                  45              


Glu Pro Leu Lys Asn Leu Glu Asp Ala Val Asn Glu Gly Leu Glu Ile 
    50                  55                  60                  


Val Arg Gly Arg Leu Gln Asn Ala Gly Leu Asn Val Thr Val Asn Ala 
65                  70                  75                  80  


Thr Phe Met Tyr Ser Asp Gly Leu Ile His Asn Ser Gly Asp Cys Arg 
                85                  90                  95      


Ser Ser Thr Cys Glu Gly Leu Asp Leu Leu Arg Lys Ile Ser Asn Ala 
            100                 105                 110         


Gln Arg Met Gly Cys Val Leu Ile Gly Pro Ser Cys Thr Tyr Ser Thr 
        115                 120                 125             


Phe Gln Met Tyr Leu Asp Thr Glu Leu Ser Tyr Pro Met Ile Ser Ala 
    130                 135                 140                 


Gly Ser Phe Gly Leu Ser Cys Asp Tyr Lys Glu Thr Leu Thr Arg Leu 
145                 150                 155                 160 


Met Ser Pro Ala Arg Lys Leu Met Tyr Phe Leu Val Asn Phe Trp Lys 
                165                 170                 175     


Thr Asn Asp Leu Pro Phe Lys Thr Tyr Ser Trp Ser Thr Ser Tyr Val 
            180                 185                 190         


Tyr Lys Asn Gly Thr Glu Thr Glu Asp Cys Phe Trp Tyr Leu Asn Ala 
        195                 200                 205             


Leu Glu Ala Ser Val Ser Tyr Phe Ser His Glu Leu Gly Phe Lys Val 
    210                 215                 220                 


Val Leu Arg Gln Asp Lys Glu Phe Gln Asp Ile Leu Met Asp His Asn 
225                 230                 235                 240 


Arg Lys Ser Asn Val Ile Ile Met Cys Gly Gly Pro Glu Phe Leu Tyr 
                245                 250                 255     


Lys Leu Lys Gly Asp Arg Ala Val Ala Glu Asp Ile Val Ile Ile Leu 
            260                 265                 270         


Val Asp Leu Phe Asn Asp Gln Tyr Phe Glu Asp Asn Val Thr Ala Pro 
        275                 280                 285             


Asp Tyr Met Lys Asn Val Leu Val Leu Thr Leu Ser Pro Gly Asn Ser 
    290                 295                 300                 


Leu Leu Asn Ser Ser Phe Ser Arg Asn Leu Ser Pro Thr Lys Arg Asp 
305                 310                 315                 320 


Phe Ala Leu Ala Tyr Leu Asn Gly Ile Leu Leu Phe Gly His Met Leu 
                325                 330                 335     


Lys Ile Phe Leu Glu Asn Gly Glu Asn Ile Thr Thr Pro Lys Phe Ala 
            340                 345                 350         


His Ala Phe Arg Asn Leu Thr Phe Glu Gly Tyr Asp Gly Pro Val Thr 
        355                 360                 365             


Leu Asp Asp Trp Gly Asp Val Asp Ser Thr Met Val Leu Leu Tyr Thr 
    370                 375                 380                 


Ser Val Asp Thr Lys Lys Tyr Lys Val Leu Leu Thr Tyr Asp Thr His 
385                 390                 395                 400 


Val Asn Lys Thr Tyr Pro Val Asp Met Ser Pro Thr Phe Thr Trp Lys 
                405                 410                 415     


Asn Ser Lys Leu Pro Asn Asp Ile Thr Gly Arg Gly Pro Gln Ile Leu 
            420                 425                 430         


Met Ile Ala Val Phe Thr Leu Thr Gly Ala Val Val Leu Leu Leu Leu 
        435                 440                 445             


Val Ala Leu Leu Met Leu Arg Lys Tyr Arg Lys Asp Tyr Glu Leu Arg 
    450                 455                 460                 


Gln Lys Lys Trp Ser His Ile Pro Pro Glu Asn Ile Phe Pro Leu Glu 
465                 470                 475                 480 


Thr Asn Glu Thr Asn His Val Ser Leu Lys Ile Asp Asp Asp Lys Arg 
                485                 490                 495     


Arg Asp Thr Ile Gln Arg Leu Arg Gln Cys Lys Tyr Asp Lys Lys Arg 
            500                 505                 510         


Val Ile Leu Lys Asp Leu Lys His Asn Asp Gly Asn Phe Thr Glu Lys 
        515                 520                 525             


Gln Lys Ile Glu Leu Asn Lys Leu Leu Gln Ile Asp Tyr Tyr Asn Leu 
    530                 535                 540                 


Thr Lys Phe Tyr Gly Thr Val Lys Leu Asp Thr Met Ile Phe Gly Val 
545                 550                 555                 560 


Ile Glu Tyr Cys Glu Arg Gly Ser Leu Arg Glu Val Leu Asn Asp Thr 
                565                 570                 575     


Ile Ser Tyr Pro Asp Gly Thr Phe Met Asp Trp Glu Phe Lys Ile Ser 
            580                 585                 590         


Val Leu Tyr Asp Ile Ala Lys Gly Met Ser Tyr Leu His Ser Ser Lys 
        595                 600                 605             


Thr Glu Val His Gly Arg Leu Lys Ser Thr Asn Cys Val Val Asp Ser 
    610                 615                 620                 


Arg Met Val Val Lys Ile Thr Asp Phe Gly Cys Asn Ser Ile Leu Pro 
625                 630                 635                 640 


Pro Lys Lys Asp Leu Trp Thr Ala Pro Glu His Leu Arg Gln Ala Asn 
                645                 650                 655     


Ile Ser Gln Lys Gly Asp Val Tyr Ser Tyr Gly Ile Ile Ala Gln Glu 
            660                 665                 670         


Ile Ile Leu Arg Lys Glu Thr Phe Tyr Thr Leu Ser Cys Arg Asp Arg 
        675                 680                 685             


Asn Glu Lys Ile Phe Arg Val Glu Asn Ser Asn Gly Met Lys Pro Phe 
    690                 695                 700                 


Arg Pro Asp Leu Phe Leu Glu Thr Ala Glu Glu Lys Glu Leu Glu Val 
705                 710                 715                 720 


Tyr Leu Leu Val Lys Asn Cys Trp Glu Glu Asp Pro Glu Lys Arg Pro 
                725                 730                 735     


Asp Phe Lys Lys Ile Glu Thr Thr Leu Ala Lys Ile Phe Gly Leu Phe 
            740                 745                 750         


His Asp Gln Lys Asn Glu Ser Tyr Met Asp Thr Leu Ile Arg Arg Leu 
        755                 760                 765             


Gln Leu Tyr Ser Arg Asn Leu Glu His Leu Val Glu Glu Arg Thr Gln 
    770                 775                 780                 


Leu Tyr Lys Ala Glu Arg Asp Arg Ala Asp Arg Leu Asn Phe Met Leu 
785                 790                 795                 800 


Leu Pro Arg Leu Val Val Lys Ser Leu Lys Glu Lys Gly Phe Val Glu 
                805                 810                 815     


Pro Glu Leu Tyr Glu Glu Val Thr Ile Tyr Phe Ser Asp Ile Val Gly 
            820                 825                 830         


Phe Thr Thr Ile Cys Lys Tyr Ser Thr Pro Met Glu Val Val Asp Met 
        835                 840                 845             


Leu Asn Asp Ile Tyr Lys Ser Phe Asp His Ile Val Asp His His Asp 
    850                 855                 860                 


Val Tyr Lys Val Glu Thr Ile Gly Asp Ala Tyr Met Val Ala Ser Gly 
865                 870                 875                 880 


Leu Pro Lys Arg Asn Gly Asn Arg His Ala Ile Asp Ile Ala Lys Met 
                885                 890                 895     


Ala Leu Glu Ile Leu Ser Phe Met Gly Thr Phe Glu Leu Glu His Leu 
            900                 905                 910         


Pro Gly Leu Pro Ile Trp Ile Arg Ile Gly Val His Ser Gly Pro Cys 
        915                 920                 925             


Ala Ala Gly Val Val Gly Ile Lys Met Pro Arg Tyr Cys Leu Phe Gly 
    930                 935                 940                 


Asp Thr Val Asn Thr Ala Ser Arg Met Glu Ser Thr Gly Leu Pro Leu 
945                 950                 955                 960 


Arg Ile His Val Ser Gly Ser Thr Ile Ala Ile Leu Lys Arg Thr Glu 
                965                 970                 975     


Cys Gln Phe Leu Tyr Glu Val Arg Gly Glu Thr Tyr Leu Lys Gly Arg 
            980                 985                 990         


Gly Asn Glu Thr Thr Tyr Trp Leu  Thr Gly Met Lys Asp  Gln Lys Phe 
        995                 1000                 1005             


Asn Leu  Pro Thr Pro Pro Thr  Val Glu Asn Gln Gln  Arg Leu Gln 
    1010                 1015                 1020             


Ala Glu  Phe Ser Asp Met Ile  Ala Asn Ser Leu Gln  Lys Arg Gln 
    1025                 1030                 1035             


Ala Ala  Gly Ile Arg Ser Gln  Lys Pro Arg Arg Val  Ala Ser Tyr 
    1040                 1045                 1050             


Lys Lys  Gly Thr Leu Glu Tyr  Leu Gln Leu Asn Thr  Thr Asp Lys 
    1055                 1060                 1065             


Glu Ser  Thr Tyr Phe 
    1070             


<210>  3180
<211>  483
<212>  PRT
<213>  Homo sapiens

<400>  3180

Met Ser Gly His Lys Cys Ser Tyr Pro Trp Asp Leu Gln Asp Arg Tyr 
1               5                   10                  15      


Ala Gln Asp Lys Ser Val Val Asn Lys Met Gln Gln Lys Tyr Trp Glu 
            20                  25                  30          


Thr Lys Gln Ala Phe Ile Lys Ala Thr Gly Lys Lys Glu Asp Glu His 
        35                  40                  45              


Val Val Ala Ser Asp Ala Asp Leu Asp Ala Lys Leu Glu Leu Phe His 
    50                  55                  60                  


Ser Ile Gln Arg Thr Cys Leu Asp Leu Ser Lys Ala Ile Val Leu Tyr 
65                  70                  75                  80  


Gln Lys Arg Ile Cys Phe Leu Ser Gln Glu Glu Asn Glu Leu Gly Lys 
                85                  90                  95      


Phe Leu Arg Ser Gln Gly Phe Gln Asp Lys Thr Arg Ala Gly Lys Met 
            100                 105                 110         


Met Gln Ala Thr Gly Lys Ala Leu Cys Phe Ser Ser Gln Gln Arg Leu 
        115                 120                 125             


Ala Leu Arg Asn Pro Leu Cys Arg Phe His Gln Glu Val Glu Thr Phe 
    130                 135                 140                 


Arg His Arg Ala Ile Ser Asp Thr Trp Leu Thr Val Asn Arg Met Glu 
145                 150                 155                 160 


Gln Cys Arg Thr Glu Tyr Arg Gly Ala Leu Leu Trp Met Lys Asp Val 
                165                 170                 175     


Ser Gln Glu Leu Asp Pro Asp Leu Tyr Lys Gln Met Glu Lys Phe Arg 
            180                 185                 190         


Lys Val Gln Thr Gln Val Arg Leu Ala Lys Lys Asn Phe Asp Lys Leu 
        195                 200                 205             


Lys Met Asp Val Cys Gln Lys Val Asp Leu Leu Gly Ala Ser Arg Cys 
    210                 215                 220                 


Asn Leu Leu Ser His Met Leu Ala Thr Tyr Gln Thr Thr Leu Leu His 
225                 230                 235                 240 


Phe Trp Glu Lys Thr Ser His Thr Met Ala Ala Ile His Glu Ser Phe 
                245                 250                 255     


Lys Gly Tyr Gln Pro Tyr Glu Phe Thr Thr Leu Lys Ser Leu Gln Asp 
            260                 265                 270         


Pro Met Lys Lys Leu Val Glu Lys Glu Glu Lys Lys Lys Ile Asn Gln 
        275                 280                 285             


Gln Glu Ser Thr Asp Ala Ala Val Gln Glu Pro Ser Gln Leu Ile Ser 
    290                 295                 300                 


Leu Glu Glu Glu Asn Gln Arg Lys Glu Ser Ser Ser Phe Lys Thr Glu 
305                 310                 315                 320 


Asp Gly Lys Ser Ile Leu Ser Ala Leu Asp Lys Gly Ser Thr His Thr 
                325                 330                 335     


Ala Cys Ser Gly Pro Ile Asp Glu Leu Leu Asp Met Lys Ser Glu Glu 
            340                 345                 350         


Gly Ala Cys Leu Gly Pro Val Ala Gly Thr Pro Glu Pro Glu Gly Ala 
        355                 360                 365             


Asp Lys Asp Asp Leu Leu Leu Leu Ser Glu Ile Phe Asn Ala Ser Ser 
    370                 375                 380                 


Leu Glu Glu Gly Glu Phe Ser Lys Glu Trp Ala Ala Val Phe Gly Asp 
385                 390                 395                 400 


Gly Gln Val Lys Glu Pro Val Pro Thr Met Ala Leu Gly Glu Pro Asp 
                405                 410                 415     


Pro Lys Ala Gln Thr Gly Ser Gly Phe Leu Pro Ser Gln Leu Leu Asp 
            420                 425                 430         


Gln Asn Met Lys Asp Leu Gln Ala Ser Leu Gln Glu Pro Ala Lys Ala 
        435                 440                 445             


Ala Ser Asp Leu Thr Ala Trp Phe Ser Leu Phe Ala Asp Leu Asp Pro 
    450                 455                 460                 


Leu Ser Asn Pro Asp Ala Val Gly Lys Thr Asp Lys Glu His Glu Leu 
465                 470                 475                 480 


Leu Asn Ala 
            


<210>  3181
<211>  499
<212>  PRT
<213>  Homo sapiens

<400>  3181

Met Thr Val Ala Thr Gly Asp Pro Ala Asp Glu Ala Ala Ala Leu Pro 
1               5                   10                  15      


Gly His Pro Gln Asp Thr Tyr Asp Pro Glu Ala Asp His Glu Cys Cys 
            20                  25                  30          


Glu Arg Val Val Ile Asn Ile Ser Gly Leu Arg Phe Glu Thr Gln Leu 
        35                  40                  45              


Lys Thr Leu Ala Gln Phe Pro Glu Thr Leu Leu Gly Asp Pro Lys Lys 
    50                  55                  60                  


Arg Met Arg Tyr Phe Asp Pro Leu Arg Asn Glu Tyr Phe Phe Asp Arg 
65                  70                  75                  80  


Asn Arg Pro Ser Phe Asp Ala Ile Leu Tyr Tyr Tyr Gln Ser Gly Gly 
                85                  90                  95      


Arg Leu Arg Arg Pro Val Asn Val Pro Leu Asp Ile Phe Ser Glu Glu 
            100                 105                 110         


Ile Arg Phe Tyr Glu Leu Gly Glu Glu Ala Met Glu Met Phe Arg Glu 
        115                 120                 125             


Asp Glu Gly Tyr Ile Lys Glu Glu Glu Arg Pro Leu Pro Glu Asn Glu 
    130                 135                 140                 


Phe Gln Arg Gln Val Trp Leu Leu Phe Glu Tyr Pro Glu Ser Ser Gly 
145                 150                 155                 160 


Pro Ala Arg Ile Ile Ala Ile Val Ser Val Met Val Ile Leu Ile Ser 
                165                 170                 175     


Ile Val Ser Phe Cys Leu Glu Thr Leu Pro Ile Phe Arg Asp Glu Asn 
            180                 185                 190         


Glu Asp Met His Gly Ser Gly Val Thr Phe His Thr Tyr Ser Asn Ser 
        195                 200                 205             


Thr Ile Gly Tyr Gln Gln Ser Thr Ser Phe Thr Asp Pro Phe Phe Ile 
    210                 215                 220                 


Val Glu Thr Leu Cys Ile Ile Trp Phe Ser Phe Glu Phe Leu Val Arg 
225                 230                 235                 240 


Phe Phe Ala Cys Pro Ser Lys Ala Gly Phe Phe Thr Asn Ile Met Asn 
                245                 250                 255     


Ile Ile Asp Ile Val Ala Ile Ile Pro Tyr Phe Ile Thr Leu Gly Thr 
            260                 265                 270         


Glu Leu Ala Glu Lys Pro Glu Asp Ala Gln Gln Gly Gln Gln Ala Met 
        275                 280                 285             


Ser Leu Ala Ile Leu Arg Val Ile Arg Leu Val Arg Val Phe Arg Ile 
    290                 295                 300                 


Phe Lys Leu Ser Arg His Ser Lys Gly Leu Gln Ile Leu Gly Gln Thr 
305                 310                 315                 320 


Leu Lys Ala Ser Met Arg Glu Leu Gly Leu Leu Ile Phe Phe Leu Phe 
                325                 330                 335     


Ile Gly Val Ile Leu Phe Ser Ser Ala Val Tyr Phe Ala Glu Ala Asp 
            340                 345                 350         


Glu Arg Glu Ser Gln Phe Pro Ser Ile Pro Asp Ala Phe Trp Trp Ala 
        355                 360                 365             


Val Val Ser Met Thr Thr Val Gly Tyr Gly Asp Met Val Pro Thr Thr 
    370                 375                 380                 


Ile Gly Gly Lys Ile Val Gly Ser Leu Cys Ala Ile Ala Gly Val Leu 
385                 390                 395                 400 


Thr Ile Ala Leu Pro Val Pro Val Ile Val Ser Asn Phe Asn Tyr Phe 
                405                 410                 415     


Tyr His Arg Glu Thr Glu Gly Glu Glu Gln Ala Gln Tyr Leu Gln Val 
            420                 425                 430         


Thr Ser Cys Pro Lys Ile Pro Ser Ser Pro Asp Leu Lys Lys Ser Arg 
        435                 440                 445             


Ser Ala Ser Thr Ile Ser Lys Ser Asp Tyr Met Glu Ile Gln Glu Gly 
    450                 455                 460                 


Val Asn Asn Ser Asn Glu Asp Phe Arg Glu Glu Asn Leu Lys Thr Ala 
465                 470                 475                 480 


Asn Cys Thr Leu Ala Asn Thr Asn Tyr Val Asn Ile Thr Lys Met Leu 
                485                 490                 495     


Thr Asp Val 
            


<210>  3182
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  3182

Met Pro Ala Gly Met Thr Lys His Gly Ser Arg Ser Thr Ser Ser Leu 
1               5                   10                  15      


Pro Pro Glu Pro Met Glu Ile Val Arg Ser Lys Ala Cys Ser Arg Arg 
            20                  25                  30          


Val Arg Leu Asn Val Gly Gly Leu Ala His Glu Val Leu Trp Arg Thr 
        35                  40                  45              


Leu Asp Arg Leu Pro Arg Thr Arg Leu Gly Lys Leu Arg Asp Cys Asn 
    50                  55                  60                  


Thr His Asp Ser Leu Leu Glu Val Cys Asp Asp Tyr Ser Leu Asp Asp 
65                  70                  75                  80  


Asn Glu Tyr Phe Phe Asp Arg His Pro Gly Ala Phe Thr Ser Ile Leu 
                85                  90                  95      


Asn Phe Tyr Arg Thr Gly Arg Leu His Met Met Glu Glu Met Cys Ala 
            100                 105                 110         


Leu Ser Phe Ser Gln Glu Leu Asp Tyr Trp Gly Ile Asp Glu Ile Tyr 
        115                 120                 125             


Leu Glu Ser Cys Cys Gln Ala Arg Tyr His Gln Lys Lys Glu Gln Met 
    130                 135                 140                 


Asn Glu Glu Leu Lys Arg Glu Ala Glu Thr Leu Arg Glu Arg Glu Gly 
145                 150                 155                 160 


Glu Glu Phe Asp Asn Thr Cys Cys Ala Glu Lys Arg Lys Lys Leu Trp 
                165                 170                 175     


Asp Leu Leu Glu Lys Pro Asn Ser Ser Val Ala Ala Lys Ile Leu Ala 
            180                 185                 190         


Ile Ile Ser Ile Met Phe Ile Val Leu Ser Thr Ile Ala Leu Ser Leu 
        195                 200                 205             


Asn Thr Leu Pro Glu Leu Gln Ser Leu Asp Glu Phe Gly Gln Ser Thr 
    210                 215                 220                 


Asp Asn Pro Gln Leu Ala His Val Glu Ala Val Cys Ile Ala Trp Phe 
225                 230                 235                 240 


Thr Met Glu Tyr Leu Leu Arg Phe Leu Ser Ser Pro Lys Lys Trp Lys 
                245                 250                 255     


Phe Phe Lys Gly Pro Leu Asn Ala Ile Asp Leu Leu Ala Ile Leu Pro 
            260                 265                 270         


Tyr Tyr Val Thr Ile Phe Leu Thr Glu Ser Asn Lys Ser Val Leu Gln 
        275                 280                 285             


Phe Gln Asn Val Arg Arg Val Val Gln Ile Phe Arg Ile Met Arg Ile 
    290                 295                 300                 


Leu Arg Ile Leu Lys Leu Ala Arg His Ser Thr Gly Leu Gln Ser Leu 
305                 310                 315                 320 


Gly Phe Thr Leu Arg Arg Ser Tyr Asn Glu Leu Gly Leu Leu Ile Leu 
                325                 330                 335     


Phe Leu Ala Met Gly Ile Met Ile Phe Ser Ser Leu Val Phe Phe Ala 
            340                 345                 350         


Glu Lys Asp Glu Asp Asp Thr Lys Phe Lys Ser Ile Pro Ala Ser Phe 
        355                 360                 365             


Trp Trp Ala Thr Ile Thr Met Thr Thr Val Gly Tyr Gly Asp Ile Tyr 
    370                 375                 380                 


Pro Lys Thr Leu Leu Gly Lys Ile Val Gly Gly Leu Cys Cys Ile Ala 
385                 390                 395                 400 


Gly Val Leu Val Ile Ala Leu Pro Ile Pro Ile Ile Val Asn Asn Phe 
                405                 410                 415     


Ser Glu Phe Tyr Lys Glu Gln Lys Arg Gln Glu Lys Ala Ile Lys Arg 
            420                 425                 430         


Arg Glu Ala Leu Glu Arg Ala Lys Arg Asn Gly Ser Ile Val Ser Met 
        435                 440                 445             


Asn Met Lys Asp Ala Phe Ala Arg Ser Ile Glu Met Met Asp Ile Val 
    450                 455                 460                 


Val Glu Lys Asn Gly Glu Asn Met Gly Lys Lys Asp Lys Val Gln Asp 
465                 470                 475                 480 


Asn His Leu Ser Pro Asn Lys Trp Lys Trp Thr Lys Arg Thr Leu Ser 
                485                 490                 495     


Glu Thr Ser Ser Ser Lys Ser Phe Glu Thr Lys Glu Gln Gly Ser Pro 
            500                 505                 510         


Glu Lys Ala Arg Ser Ser Ser Ser Pro Gln His Leu Asn Val Gln Gln 
        515                 520                 525             


Leu Glu Asp Met Tyr Asn Lys Met Ala Lys Thr Gln Ser Gln Pro Ile 
    530                 535                 540                 


Leu Asn Thr Lys Glu Ser Ala Ala Gln Ser Lys Pro Lys Glu Glu Leu 
545                 550                 555                 560 


Glu Met Glu Ser Ile Pro Ser Pro Val Ala Pro Leu Pro Thr Arg Thr 
                565                 570                 575     


Glu Gly Val Ile Asp Met Arg Ser Met Ser Ser Ile Asp Ser Phe Ile 
            580                 585                 590         


Ser Cys Ala Thr Asp Phe Pro Glu Ala Thr Arg Phe Ser His Ser Pro 
        595                 600                 605             


Leu Thr Ser Leu Pro Ser Lys Thr Gly Gly Ser Thr Ala Pro Glu Val 
    610                 615                 620                 


Gly Trp Arg Gly Ala Leu Gly Ala Ser Gly Gly Arg Phe Val Glu Ala 
625                 630                 635                 640 


Asn Pro Ser Pro Asp Ala Ser Gln His Ser Ser Phe Phe Ile Glu Ser 
                645                 650                 655     


Pro Lys Ser Ser Met Lys Thr Asn Asn Pro Leu Lys Leu Arg Ala Leu 
            660                 665                 670         


Lys Val Asn Phe Met Glu Gly Asp Pro Ser Pro Leu Leu Pro Val Leu 
        675                 680                 685             


Gly Met Tyr His Asp Pro Leu Arg Asn Arg Gly Ser Ala Ala Ala Ala 
    690                 695                 700                 


Val Ala Gly Leu Glu Cys Ala Thr Leu Leu Asp Lys Ala Val Leu Ser 
705                 710                 715                 720 


Pro Glu Ser Ser Ile Tyr Thr Thr Ala Ser Ala Lys Thr Pro Pro Arg 
                725                 730                 735     


Ser Pro Glu Lys His Thr Ala Ile Ala Phe Asn Phe Glu Ala Gly Val 
            740                 745                 750         


His Gln Tyr Ile Asp Ala Asp Thr Asp Asp Glu Gly Gln Leu Leu Tyr 
        755                 760                 765             


Ser Val Asp Ser Ser Pro Pro Lys Ser Leu Pro Gly Ser Thr Ser Pro 
    770                 775                 780                 


Lys Phe Ser Thr Gly Thr Arg Ser Glu Lys Asn His Phe Glu Ser Ser 
785                 790                 795                 800 


Pro Leu Pro Thr Ser Pro Lys Phe Leu Arg Gln Asn Cys Ile Tyr Ser 
                805                 810                 815     


Thr Glu Ala Leu Thr Gly Lys Gly Pro Ser Gly Gln Glu Lys Cys Lys 
            820                 825                 830         


Leu Glu Asn His Ile Ser Pro Asp Val Arg Val Leu Pro Gly Gly Gly 
        835                 840                 845             


Ala His Gly Ser Thr Arg Asp Gln Ser Ile 
    850                 855             


<210>  3183
<211>  511
<212>  PRT
<213>  Homo sapiens

<400>  3183

Met Gly Gln Gly Asp Glu Ser Glu Arg Ile Val Ile Asn Val Gly Gly 
1               5                   10                  15      


Thr Arg His Gln Thr Tyr Arg Ser Thr Leu Arg Thr Leu Pro Gly Thr 
            20                  25                  30          


Arg Leu Ala Trp Leu Ala Glu Pro Asp Ala His Ser His Phe Asp Tyr 
        35                  40                  45              


Asp Pro Arg Ala Asp Glu Phe Phe Phe Asp Arg His Pro Gly Val Phe 
    50                  55                  60                  


Ala His Ile Leu Asn Tyr Tyr Arg Thr Gly Lys Leu His Cys Pro Ala 
65                  70                  75                  80  


Asp Val Cys Gly Pro Leu Tyr Glu Glu Glu Leu Ala Phe Trp Gly Ile 
                85                  90                  95      


Asp Glu Thr Asp Val Glu Pro Cys Cys Trp Met Thr Tyr Arg Gln His 
            100                 105                 110         


Arg Asp Ala Glu Glu Ala Leu Asp Ser Phe Gly Gly Ala Pro Leu Asp 
        115                 120                 125             


Asn Ser Ala Asp Asp Ala Asp Ala Asp Gly Pro Gly Asp Ser Gly Asp 
    130                 135                 140                 


Gly Glu Asp Glu Leu Glu Met Thr Lys Arg Leu Ala Leu Ser Asp Ser 
145                 150                 155                 160 


Pro Asp Gly Arg Pro Gly Gly Phe Trp Arg Arg Trp Gln Pro Arg Ile 
                165                 170                 175     


Trp Ala Leu Phe Glu Asp Pro Tyr Ser Ser Arg Tyr Ala Arg Tyr Val 
            180                 185                 190         


Ala Phe Ala Ser Leu Phe Phe Ile Leu Val Ser Ile Thr Thr Phe Cys 
        195                 200                 205             


Leu Glu Thr His Glu Arg Phe Asn Pro Ile Val Asn Lys Thr Glu Ile 
    210                 215                 220                 


Glu Asn Val Arg Asn Gly Thr Gln Val Arg Tyr Tyr Arg Glu Ala Glu 
225                 230                 235                 240 


Thr Glu Ala Phe Leu Thr Tyr Ile Glu Gly Val Cys Val Val Trp Phe 
                245                 250                 255     


Thr Phe Glu Phe Leu Met Arg Val Ile Phe Cys Pro Asn Lys Val Glu 
            260                 265                 270         


Phe Ile Lys Asn Ser Leu Asn Ile Ile Asp Phe Val Ala Ile Leu Pro 
        275                 280                 285             


Phe Tyr Leu Glu Val Gly Leu Ser Gly Leu Ser Ser Lys Ala Ala Lys 
    290                 295                 300                 


Asp Val Leu Gly Phe Leu Arg Val Val Arg Phe Val Arg Ile Leu Arg 
305                 310                 315                 320 


Ile Phe Lys Leu Thr Arg His Phe Val Gly Leu Arg Val Leu Gly His 
                325                 330                 335     


Thr Leu Arg Ala Ser Thr Asn Glu Phe Leu Leu Leu Ile Ile Phe Leu 
            340                 345                 350         


Ala Leu Gly Val Leu Ile Phe Ala Thr Met Ile Tyr Tyr Ala Glu Arg 
        355                 360                 365             


Ile Gly Ala Gln Pro Asn Asp Pro Ser Ala Ser Glu His Thr His Phe 
    370                 375                 380                 


Lys Asn Ile Pro Ile Gly Phe Trp Trp Ala Val Val Thr Met Thr Thr 
385                 390                 395                 400 


Leu Gly Tyr Gly Asp Met Tyr Pro Gln Thr Trp Ser Gly Met Leu Val 
                405                 410                 415     


Gly Ala Leu Cys Ala Leu Ala Gly Val Leu Thr Ile Ala Met Pro Val 
            420                 425                 430         


Pro Val Ile Val Asn Asn Phe Gly Met Tyr Tyr Ser Leu Ala Met Ala 
        435                 440                 445             


Lys Gln Lys Leu Pro Lys Lys Lys Lys Lys His Ile Pro Arg Pro Pro 
    450                 455                 460                 


Gln Leu Gly Ser Pro Asn Tyr Cys Lys Ser Val Val Asn Ser Pro His 
465                 470                 475                 480 


His Ser Thr Gln Ser Asp Thr Cys Pro Leu Ala Gln Glu Glu Ile Leu 
                485                 490                 495     


Glu Ile Asn Arg Ala Gly Arg Lys Pro Leu Arg Gly Met Ser Ile 
            500                 505                 510     


<210>  3184
<211>  757
<212>  PRT
<213>  Homo sapiens

<400>  3184

Met Leu Ser Ser Val Cys Val Ser Ser Phe Arg Gly Arg Gln Gly Ala 
1               5                   10                  15      


Ser Lys Gln Gln Pro Ala Pro Pro Pro Gln Pro Pro Glu Ser Pro Pro 
            20                  25                  30          


Pro Pro Pro Leu Pro Pro Gln Gln Gln Gln Pro Ala Gln Pro Gly Pro 
        35                  40                  45              


Ala Ala Ser Pro Ala Gly Pro Pro Ala Pro Arg Gly Pro Gly Asp Arg 
    50                  55                  60                  


Arg Ala Glu Pro Cys Pro Gly Leu Pro Ala Ala Ala Met Gly Arg His 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Asp Ser Gly Lys Ile Val Ile Asn Val Gly Gly 
                85                  90                  95      


Val Arg His Glu Thr Tyr Arg Ser Thr Leu Arg Thr Leu Pro Gly Thr 
            100                 105                 110         


Arg Leu Ala Gly Leu Thr Glu Pro Glu Ala Ala Ala Arg Phe Asp Tyr 
        115                 120                 125             


Asp Pro Gly Ala Asp Glu Phe Phe Phe Asp Arg His Pro Gly Val Phe 
    130                 135                 140                 


Ala Tyr Val Leu Asn Tyr Tyr Arg Thr Gly Lys Leu His Cys Pro Ala 
145                 150                 155                 160 


Asp Val Cys Gly Pro Leu Phe Glu Glu Glu Leu Gly Phe Trp Gly Ile 
                165                 170                 175     


Asp Glu Thr Asp Val Glu Ala Cys Cys Trp Met Thr Tyr Arg Gln His 
            180                 185                 190         


Arg Asp Ala Glu Glu Ala Leu Asp Ser Phe Glu Ala Pro Asp Pro Ala 
        195                 200                 205             


Gly Ala Ala Asn Ala Ala Asn Ala Ala Gly Ala His Asp Gly Gly Leu 
    210                 215                 220                 


Asp Asp Glu Ala Gly Ala Gly Gly Gly Gly Leu Asp Gly Ala Gly Gly 
225                 230                 235                 240 


Glu Leu Lys Arg Leu Cys Phe Gln Asp Ala Gly Gly Gly Ala Gly Gly 
                245                 250                 255     


Pro Pro Gly Gly Ala Gly Gly Ala Gly Gly Thr Trp Trp Arg Arg Trp 
            260                 265                 270         


Gln Pro Arg Val Trp Ala Leu Phe Glu Asp Pro Tyr Ser Ser Arg Ala 
        275                 280                 285             


Ala Arg Tyr Val Ala Phe Ala Ser Leu Phe Phe Ile Leu Ile Ser Ile 
    290                 295                 300                 


Thr Thr Phe Cys Leu Glu Thr His Glu Gly Phe Ile His Ile Ser Asn 
305                 310                 315                 320 


Lys Thr Val Thr Gln Ala Ser Pro Ile Pro Gly Ala Pro Pro Glu Asn 
                325                 330                 335     


Ile Thr Asn Val Glu Val Glu Thr Glu Pro Phe Leu Thr Tyr Val Glu 
            340                 345                 350         


Gly Val Cys Val Val Trp Phe Thr Phe Glu Phe Leu Met Arg Ile Thr 
        355                 360                 365             


Phe Cys Pro Asp Lys Val Glu Phe Leu Lys Ser Ser Leu Asn Ile Ile 
    370                 375                 380                 


Asp Cys Val Ala Ile Leu Pro Phe Tyr Leu Glu Val Gly Leu Ser Gly 
385                 390                 395                 400 


Leu Ser Ser Lys Ala Ala Lys Asp Val Leu Gly Phe Leu Arg Val Val 
                405                 410                 415     


Arg Phe Val Arg Ile Leu Arg Ile Phe Lys Leu Thr Arg His Phe Val 
            420                 425                 430         


Gly Leu Arg Val Leu Gly His Thr Leu Arg Ala Ser Thr Asn Glu Phe 
        435                 440                 445             


Leu Leu Leu Ile Ile Phe Leu Ala Leu Gly Val Leu Ile Phe Ala Thr 
    450                 455                 460                 


Met Ile Tyr Tyr Ala Glu Arg Ile Gly Ala Asp Pro Asp Asp Ile Leu 
465                 470                 475                 480 


Gly Ser Asn His Thr Tyr Phe Lys Asn Ile Pro Ile Gly Phe Trp Trp 
                485                 490                 495     


Ala Val Val Thr Met Thr Thr Leu Gly Tyr Gly Asp Met Tyr Pro Lys 
            500                 505                 510         


Thr Trp Ser Gly Met Leu Val Gly Ala Leu Cys Ala Leu Ala Gly Val 
        515                 520                 525             


Leu Thr Ile Ala Met Pro Val Pro Val Ile Val Asn Asn Phe Gly Met 
    530                 535                 540                 


Tyr Tyr Ser Leu Ala Met Ala Lys Gln Lys Leu Pro Lys Lys Lys Asn 
545                 550                 555                 560 


Lys His Ile Pro Arg Pro Pro Gln Pro Gly Ser Pro Asn Tyr Cys Lys 
                565                 570                 575     


Pro Asp Pro Pro Pro Pro Pro Pro Pro His Pro His His Gly Ser Gly 
            580                 585                 590         


Gly Ile Ser Pro Pro Pro Pro Ile Thr Pro Pro Ser Met Gly Val Thr 
        595                 600                 605             


Val Ala Gly Ala Tyr Pro Ala Gly Pro His Thr His Pro Gly Leu Leu 
    610                 615                 620                 


Arg Gly Gly Ala Gly Gly Leu Gly Ile Met Gly Leu Pro Pro Leu Pro 
625                 630                 635                 640 


Ala Pro Gly Glu Pro Cys Pro Leu Ala Gln Glu Glu Val Ile Glu Ile 
                645                 650                 655     


Asn Arg Ala Asp Pro Arg Pro Asn Gly Asp Pro Ala Ala Ala Ala Leu 
            660                 665                 670         


Ala His Glu Asp Cys Pro Ala Ile Asp Gln Pro Ala Met Ser Pro Glu 
        675                 680                 685             


Asp Lys Ser Pro Ile Thr Pro Gly Ser Arg Gly Arg Tyr Ser Arg Asp 
    690                 695                 700                 


Arg Ala Cys Phe Leu Leu Thr Asp Tyr Ala Pro Ser Pro Asp Gly Ser 
705                 710                 715                 720 


Ile Arg Lys Ala Thr Gly Ala Pro Pro Leu Pro Pro Gln Asp Trp Arg 
                725                 730                 735     


Lys Pro Gly Pro Pro Ser Phe Leu Pro Asp Leu Asn Ala Asn Ala Ala 
            740                 745                 750         


Ala Trp Ile Ser Pro 
        755         


<210>  3185
<211>  635
<212>  PRT
<213>  Homo sapiens

<400>  3185

Met Ile Ser Ser Val Cys Val Ser Ser Tyr Arg Gly Arg Lys Ser Gly 
1               5                   10                  15      


Asn Lys Pro Pro Ser Lys Thr Cys Leu Lys Glu Glu Met Ala Lys Gly 
            20                  25                  30          


Glu Ala Ser Glu Lys Ile Ile Ile Asn Val Gly Gly Thr Arg His Glu 
        35                  40                  45              


Thr Tyr Arg Ser Thr Leu Arg Thr Leu Pro Gly Thr Arg Leu Ala Trp 
    50                  55                  60                  


Leu Ala Asp Pro Asp Gly Gly Gly Arg Pro Glu Thr Asp Gly Gly Gly 
65                  70                  75                  80  


Val Gly Ser Ser Gly Ser Ser Gly Gly Gly Gly Cys Glu Phe Phe Phe 
                85                  90                  95      


Asp Arg His Pro Gly Val Phe Ala Tyr Val Leu Asn Tyr Tyr Arg Thr 
            100                 105                 110         


Gly Lys Leu His Cys Pro Ala Asp Val Cys Gly Pro Leu Phe Glu Glu 
        115                 120                 125             


Glu Leu Thr Phe Trp Gly Ile Asp Glu Thr Asp Val Glu Pro Cys Cys 
    130                 135                 140                 


Trp Met Thr Tyr Arg Gln His Arg Asp Ala Glu Glu Ala Leu Asp Ile 
145                 150                 155                 160 


Phe Glu Ser Pro Asp Gly Gly Gly Ser Gly Ala Gly Pro Ser Asp Glu 
                165                 170                 175     


Ala Gly Asp Asp Glu Arg Glu Leu Ala Leu Gln Arg Leu Gly Pro His 
            180                 185                 190         


Glu Gly Gly Ala Gly His Gly Ala Gly Ser Gly Gly Cys Arg Gly Trp 
        195                 200                 205             


Gln Pro Arg Met Trp Ala Leu Phe Glu Asp Pro Tyr Ser Ser Arg Ala 
    210                 215                 220                 


Ala Arg Val Val Ala Phe Ala Ser Leu Phe Phe Ile Leu Val Ser Ile 
225                 230                 235                 240 


Thr Thr Phe Cys Leu Glu Thr His Glu Ala Phe Asn Ile Asp Arg Asn 
                245                 250                 255     


Val Thr Glu Ile Leu Arg Val Gly Asn Ile Thr Ser Val His Phe Arg 
            260                 265                 270         


Arg Glu Val Glu Thr Glu Pro Ile Leu Thr Tyr Ile Glu Gly Val Cys 
        275                 280                 285             


Val Leu Trp Phe Thr Leu Glu Phe Leu Val Arg Ile Val Cys Cys Pro 
    290                 295                 300                 


Asp Thr Leu Asp Phe Val Lys Asn Leu Leu Asn Ile Ile Asp Phe Val 
305                 310                 315                 320 


Ala Ile Leu Pro Phe Tyr Leu Glu Val Gly Leu Ser Gly Leu Ser Ser 
                325                 330                 335     


Lys Ala Ala Arg Asp Val Leu Gly Phe Leu Arg Val Val Arg Phe Val 
            340                 345                 350         


Arg Ile Leu Arg Ile Phe Lys Leu Thr Arg His Phe Val Gly Leu Arg 
        355                 360                 365             


Val Leu Gly His Thr Leu Arg Ala Ser Thr Asn Glu Phe Leu Leu Leu 
    370                 375                 380                 


Ile Ile Phe Leu Ala Leu Gly Val Leu Ile Phe Ala Thr Met Ile Tyr 
385                 390                 395                 400 


Tyr Ala Glu Arg Ile Gly Ala Arg Pro Ser Asp Pro Arg Gly Asn Asp 
                405                 410                 415     


His Thr Asp Phe Lys Asn Ile Pro Ile Gly Phe Trp Trp Ala Val Val 
            420                 425                 430         


Thr Met Thr Thr Leu Gly Tyr Gly Asp Met Tyr Pro Lys Thr Trp Ser 
        435                 440                 445             


Gly Met Leu Val Gly Ala Leu Cys Ala Leu Ala Gly Val Leu Thr Ile 
    450                 455                 460                 


Ala Met Pro Val Pro Val Ile Val Asn Asn Phe Gly Met Tyr Tyr Ser 
465                 470                 475                 480 


Leu Ala Met Ala Lys Gln Lys Leu Pro Lys Lys Arg Lys Lys His Val 
                485                 490                 495     


Pro Arg Pro Ala Gln Leu Glu Ser Pro Met Tyr Cys Lys Ser Glu Glu 
            500                 505                 510         


Thr Ser Pro Arg Asp Ser Thr Cys Ser Asp Thr Ser Pro Pro Ala Arg 
        515                 520                 525             


Glu Glu Gly Met Ile Glu Arg Lys Arg Ala Asp Ser Lys Gln Asn Gly 
    530                 535                 540                 


Asp Ala Asn Ala Val Leu Ser Asp Glu Glu Gly Ala Gly Leu Thr Gln 
545                 550                 555                 560 


Pro Leu Ala Ser Ser Pro Thr Pro Glu Glu Arg Arg Ala Leu Arg Arg 
                565                 570                 575     


Ser Thr Thr Arg Asp Arg Asn Lys Lys Ala Ala Ala Cys Phe Leu Leu 
            580                 585                 590         


Ser Thr Gly Asp Tyr Ala Cys Ala Asp Gly Ser Val Arg Lys Gly Thr 
        595                 600                 605             


Phe Val Leu Arg Asp Leu Pro Leu Gln His Ser Pro Glu Ala Ala Cys 
    610                 615                 620                 


Pro Pro Thr Ala Gly Thr Leu Phe Leu Pro His 
625                 630                 635 


<210>  3186
<211>  647
<212>  PRT
<213>  Homo sapiens

<400>  3186

Met Ala Ala Gly Leu Ala Thr Trp Leu Pro Phe Ala Arg Ala Ala Ala 
1               5                   10                  15      


Val Gly Trp Leu Pro Leu Ala Gln Gln Pro Leu Pro Pro Ala Pro Gly 
            20                  25                  30          


Val Lys Ala Ser Arg Gly Asp Glu Val Leu Val Val Asn Val Ser Gly 
        35                  40                  45              


Arg Arg Phe Glu Thr Trp Lys Asn Thr Leu Asp Arg Tyr Pro Asp Thr 
    50                  55                  60                  


Leu Leu Gly Ser Ser Glu Lys Glu Phe Phe Tyr Asp Ala Asp Ser Gly 
65                  70                  75                  80  


Glu Tyr Phe Phe Asp Arg Asp Pro Asp Met Phe Arg His Val Leu Asn 
                85                  90                  95      


Phe Tyr Arg Thr Gly Arg Leu His Cys Pro Arg Gln Glu Cys Ile Gln 
            100                 105                 110         


Ala Phe Asp Glu Glu Leu Ala Phe Tyr Gly Leu Val Pro Glu Leu Val 
        115                 120                 125             


Gly Asp Cys Cys Leu Glu Glu Tyr Arg Asp Arg Lys Lys Glu Asn Ala 
    130                 135                 140                 


Glu Arg Leu Ala Glu Asp Glu Glu Ala Glu Gln Ala Gly Asp Gly Pro 
145                 150                 155                 160 


Ala Leu Pro Ala Gly Ser Ser Leu Arg Gln Arg Leu Trp Arg Ala Phe 
                165                 170                 175     


Glu Asn Pro His Thr Ser Thr Ala Ala Leu Val Phe Tyr Tyr Val Thr 
            180                 185                 190         


Gly Phe Phe Ile Ala Val Ser Val Ile Ala Asn Val Val Glu Thr Ile 
        195                 200                 205             


Pro Cys Arg Gly Ser Ala Arg Arg Ser Ser Arg Glu Gln Pro Cys Gly 
    210                 215                 220                 


Glu Arg Phe Pro Gln Ala Phe Phe Cys Met Asp Thr Ala Cys Val Leu 
225                 230                 235                 240 


Ile Phe Thr Gly Glu Tyr Leu Leu Arg Leu Phe Ala Ala Pro Ser Arg 
                245                 250                 255     


Cys Arg Phe Leu Arg Ser Val Met Ser Leu Ile Asp Val Val Ala Ile 
            260                 265                 270         


Leu Pro Tyr Tyr Ile Gly Leu Leu Val Pro Lys Asn Asp Asp Val Ser 
        275                 280                 285             


Gly Ala Phe Val Thr Leu Arg Val Phe Arg Val Phe Arg Ile Phe Lys 
    290                 295                 300                 


Phe Ser Arg His Ser Gln Gly Leu Arg Ile Leu Gly Tyr Thr Leu Lys 
305                 310                 315                 320 


Ser Cys Ala Ser Glu Leu Gly Phe Leu Leu Phe Ser Leu Thr Met Ala 
                325                 330                 335     


Ile Ile Ile Phe Ala Thr Val Met Phe Tyr Ala Glu Lys Gly Thr Asn 
            340                 345                 350         


Lys Thr Asn Phe Thr Ser Ile Pro Ala Ala Phe Trp Tyr Thr Ile Val 
        355                 360                 365             


Thr Met Thr Thr Leu Gly Tyr Gly Asp Met Val Pro Ser Thr Ile Ala 
    370                 375                 380                 


Gly Lys Ile Phe Gly Ser Ile Cys Ser Leu Ser Gly Val Leu Val Ile 
385                 390                 395                 400 


Ala Leu Pro Val Pro Val Ile Val Ser Asn Phe Ser Arg Ile Tyr His 
                405                 410                 415     


Gln Asn Gln Arg Ala Asp Lys Arg Arg Ala Gln Gln Lys Val Arg Leu 
            420                 425                 430         


Ala Arg Ile Arg Leu Ala Lys Ser Gly Thr Thr Asn Ala Phe Leu Gln 
        435                 440                 445             


Tyr Lys Gln Asn Gly Gly Leu Glu Asp Ser Gly Ser Gly Glu Glu Gln 
    450                 455                 460                 


Ala Leu Cys Val Arg Asn Arg Ser Ala Phe Glu Gln Gln His His His 
465                 470                 475                 480 


Leu Leu His Cys Leu Glu Lys Thr Thr Cys His Glu Phe Thr Asp Glu 
                485                 490                 495     


Leu Thr Phe Ser Glu Ala Leu Gly Ala Val Ser Pro Gly Gly Arg Thr 
            500                 505                 510         


Ser Arg Ser Thr Ser Val Ser Ser Gln Pro Val Gly Pro Gly Ser Leu 
        515                 520                 525             


Leu Ser Ser Cys Cys Pro Arg Arg Ala Lys Arg Arg Ala Ile Arg Leu 
    530                 535                 540                 


Ala Asn Ser Thr Ala Ser Val Ser Arg Gly Ser Met Gln Glu Leu Asp 
545                 550                 555                 560 


Met Leu Ala Gly Leu Arg Arg Ser His Ala Pro Gln Ser Arg Ser Ser 
                565                 570                 575     


Leu Asn Ala Lys Pro His Asp Ser Leu Asp Leu Asn Cys Asp Ser Arg 
            580                 585                 590         


Asp Phe Val Ala Ala Ile Ile Ser Ile Pro Thr Pro Pro Ala Asn Thr 
        595                 600                 605             


Pro Asp Glu Ser Gln Pro Ser Ser Pro Gly Gly Gly Gly Arg Ala Gly 
    610                 615                 620                 


Ser Thr Leu Arg Asn Ser Ser Leu Gly Thr Pro Cys Leu Phe Pro Glu 
625                 630                 635                 640 


Thr Val Lys Ile Ser Ser Leu 
                645         


<210>  3187
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  3187

Met Ala Ala Gly Val Ala Ala Trp Leu Pro Phe Ala Arg Ala Ala Ala 
1               5                   10                  15      


Ile Gly Trp Met Pro Val Ala Asn Cys Pro Met Pro Leu Ala Pro Ala 
            20                  25                  30          


Asp Lys Asn Lys Arg Gln Asp Glu Leu Ile Val Leu Asn Val Ser Gly 
        35                  40                  45              


Arg Arg Phe Gln Thr Trp Arg Thr Thr Leu Glu Arg Tyr Pro Asp Thr 
    50                  55                  60                  


Leu Leu Gly Ser Thr Glu Lys Glu Phe Phe Phe Asn Glu Asp Thr Lys 
65                  70                  75                  80  


Glu Tyr Phe Phe Asp Arg Asp Pro Glu Val Phe Arg Cys Val Leu Asn 
                85                  90                  95      


Phe Tyr Arg Thr Gly Lys Leu His Tyr Pro Arg Tyr Glu Cys Ile Ser 
            100                 105                 110         


Ala Tyr Asp Asp Glu Leu Ala Phe Tyr Gly Ile Leu Pro Glu Ile Ile 
        115                 120                 125             


Gly Asp Cys Cys Tyr Glu Glu Tyr Lys Asp Arg Lys Arg Glu Asn Ala 
    130                 135                 140                 


Glu Arg Leu Met Asp Asp Asn Asp Ser Glu Asn Asn Gln Glu Ser Met 
145                 150                 155                 160 


Pro Ser Leu Ser Phe Arg Gln Thr Met Trp Arg Ala Phe Glu Asn Pro 
                165                 170                 175     


His Thr Ser Thr Leu Ala Leu Val Phe Tyr Tyr Val Thr Gly Phe Phe 
            180                 185                 190         


Ile Ala Val Ser Val Ile Thr Asn Val Val Glu Thr Val Pro Cys Gly 
        195                 200                 205             


Thr Val Pro Gly Ser Lys Glu Leu Pro Cys Gly Glu Arg Tyr Ser Val 
    210                 215                 220                 


Ala Phe Phe Cys Leu Asp Thr Ala Cys Val Met Ile Phe Thr Val Glu 
225                 230                 235                 240 


Tyr Leu Leu Arg Leu Phe Ala Ala Pro Ser Arg Tyr Arg Phe Ile Arg 
                245                 250                 255     


Ser Val Met Ser Ile Ile Asp Val Val Ala Ile Met Pro Tyr Tyr Ile 
            260                 265                 270         


Gly Leu Val Met Thr Asn Asn Glu Asp Val Ser Gly Ala Phe Val Thr 
        275                 280                 285             


Leu Arg Val Phe Arg Val Phe Arg Ile Phe Lys Phe Ser Arg His Ser 
    290                 295                 300                 


Gln Gly Leu Arg Ile Leu Gly Tyr Thr Leu Lys Ser Cys Ala Ser Glu 
305                 310                 315                 320 


Leu Gly Phe Leu Leu Phe Ser Leu Thr Met Ala Ile Ile Ile Phe Ala 
                325                 330                 335     


Thr Val Met Phe Tyr Ala Glu Lys Gly Ser Ser Ala Ser Lys Phe Thr 
            340                 345                 350         


Ser Ile Pro Ala Ser Phe Trp Tyr Thr Ile Val Thr Met Thr Thr Leu 
        355                 360                 365             


Gly Tyr Gly Asp Met Val Pro Lys Thr Ile Ala Gly Lys Ile Phe Gly 
    370                 375                 380                 


Ser Ile Cys Ser Leu Ser Gly Val Leu Val Ile Ala Leu Pro Val Pro 
385                 390                 395                 400 


Val Ile Val Ser Asn Phe Ser Arg Ile Tyr His Gln Asn Gln Arg Ala 
                405                 410                 415     


Asp Lys Arg Arg Ala Gln Lys Lys Ala Arg Leu Ala Arg Ile Arg Val 
            420                 425                 430         


Ala Lys Thr Gly Ser Ser Asn Ala Tyr Leu His Ser Lys Arg Asn Gly 
        435                 440                 445             


Leu Leu Asn Glu Ala Leu Glu Leu Thr Gly Thr Pro Glu Glu Glu His 
    450                 455                 460                 


Met Gly Lys Thr Thr Ser Leu Ile Glu Ser Gln His His His Leu Leu 
465                 470                 475                 480 


His Cys Leu Glu Lys Thr Thr Gly Leu Ser Tyr Leu Val Asp Asp Pro 
                485                 490                 495     


Leu Leu Ser Val Arg Thr Ser Thr Ile Lys Asn His Glu Phe Ile Asp 
            500                 505                 510         


Glu Gln Met Phe Glu Gln Asn Cys Met Glu Ser Ser Met Gln Asn Tyr 
        515                 520                 525             


Pro Ser Thr Arg Ser Pro Ser Leu Ser Ser His Pro Gly Leu Thr Thr 
    530                 535                 540                 


Thr Cys Cys Ser Arg Arg Ser Lys Lys Thr Thr His Leu Pro Asn Ser 
545                 550                 555                 560 


Asn Leu Pro Ala Thr Arg Leu Arg Ser Met Gln Glu Leu Ser Thr Ile 
                565                 570                 575     


His Ile Gln Gly Ser Glu Gln Pro Ser Leu Thr Thr Ser Arg Ser Ser 
            580                 585                 590         


Leu Asn Leu Lys Ala Asp Asp Gly Leu Arg Pro Asn Cys Lys Thr Ser 
        595                 600                 605             


Gln Ile Thr Thr Ala Ile Ile Ser Ile Pro Thr Pro Pro Ala Leu Thr 
    610                 615                 620                 


Pro Glu Gly Glu Ser Arg Pro Pro Pro Ala Ser Pro Gly Pro Asn Thr 
625                 630                 635                 640 


Asn Ile Pro Ser Ile Ala Ser Asn Val Val Lys Val Ser Ala Leu 
                645                 650                 655 


<210>  3188
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  3188

Met His Gly His Ser Arg Asn Gly Gln Ala His Val Pro Arg Arg Lys 
1               5                   10                  15      


Arg Arg Asn Arg Phe Val Lys Lys Asn Gly Gln Cys Asn Val Tyr Phe 
            20                  25                  30          


Ala Asn Leu Ser Asn Lys Ser Gln Arg Tyr Met Ala Asp Ile Phe Thr 
        35                  40                  45              


Thr Cys Val Asp Thr Arg Trp Arg Tyr Met Leu Met Ile Phe Ser Ala 
    50                  55                  60                  


Ala Phe Leu Val Ser Trp Leu Phe Phe Gly Leu Leu Phe Trp Cys Ile 
65                  70                  75                  80  


Ala Phe Phe His Gly Asp Leu Glu Ala Ser Pro Gly Val Pro Ala Ala 
                85                  90                  95      


Gly Gly Pro Ala Ala Gly Gly Gly Gly Ala Ala Pro Val Ala Pro Lys 
            100                 105                 110         


Pro Cys Ile Met His Val Asn Gly Phe Leu Gly Ala Phe Leu Phe Ser 
        115                 120                 125             


Val Glu Thr Gln Thr Thr Ile Gly Tyr Gly Phe Arg Cys Val Thr Glu 
    130                 135                 140                 


Glu Cys Pro Leu Ala Val Ile Ala Val Val Val Gln Ser Ile Val Gly 
145                 150                 155                 160 


Cys Val Ile Asp Ser Phe Met Ile Gly Thr Ile Met Ala Lys Met Ala 
                165                 170                 175     


Arg Pro Lys Lys Arg Ala Gln Thr Leu Leu Phe Ser His His Ala Val 
            180                 185                 190         


Ile Ser Val Arg Asp Gly Lys Leu Cys Leu Met Trp Arg Val Gly Asn 
        195                 200                 205             


Leu Arg Lys Ser His Ile Val Glu Ala His Val Arg Ala Gln Leu Ile 
    210                 215                 220                 


Lys Pro Tyr Met Thr Gln Glu Gly Glu Tyr Leu Pro Leu Asp Gln Arg 
225                 230                 235                 240 


Asp Leu Asn Val Gly Tyr Asp Ile Gly Leu Asp Arg Ile Phe Leu Val 
                245                 250                 255     


Ser Pro Ile Ile Ile Val His Glu Ile Asp Glu Asp Ser Pro Leu Tyr 
            260                 265                 270         


Gly Met Gly Lys Glu Glu Leu Glu Ser Glu Asp Phe Glu Ile Val Val 
        275                 280                 285             


Ile Leu Glu Gly Met Val Glu Ala Thr Ala Met Thr Thr Gln Ala Arg 
    290                 295                 300                 


Ser Ser Tyr Leu Ala Ser Glu Ile Leu Trp Gly His Arg Phe Glu Pro 
305                 310                 315                 320 


Val Val Phe Glu Glu Lys Ser His Tyr Lys Val Asp Tyr Ser Arg Phe 
                325                 330                 335     


His Lys Thr Tyr Glu Val Ala Gly Thr Pro Cys Cys Ser Ala Arg Glu 
            340                 345                 350         


Leu Gln Glu Ser Lys Ile Thr Val Leu Pro Ala Pro Pro Pro Pro Pro 
        355                 360                 365             


Ser Ala Phe Cys Tyr Glu Asn Glu Leu Ala Leu Met Ser Gln Glu Glu 
    370                 375                 380                 


Glu Glu Met Glu Glu Glu Ala Ala Ala Ala Ala Ala Val Ala Ala Gly 
385                 390                 395                 400 


Leu Gly Leu Glu Ala Gly Ser Lys Glu Glu Ala Gly Ile Ile Arg Met 
                405                 410                 415     


Leu Glu Phe Gly Ser His Leu Asp Leu Glu Arg Met Gln Ala Ser Leu 
            420                 425                 430         


Pro Leu Asp Asn Ile Ser Tyr Arg Arg Glu Ser Ala Ile 
        435                 440                 445 


<210>  3189
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  3189

Met Leu Ala Arg Lys Ser Ile Ile Pro Glu Glu Tyr Val Leu Ala Arg 
1               5                   10                  15      


Ile Ala Ala Glu Asn Leu Arg Lys Pro Arg Ile Arg Asp Arg Leu Pro 
            20                  25                  30          


Lys Ala Arg Phe Ile Ala Lys Ser Gly Ala Cys Asn Leu Ala His Lys 
        35                  40                  45              


Asn Ile Arg Glu Gln Gly Arg Phe Leu Gln Asp Ile Phe Thr Thr Leu 
    50                  55                  60                  


Val Asp Leu Lys Trp Arg His Thr Leu Val Ile Phe Thr Met Ser Phe 
65                  70                  75                  80  


Leu Cys Ser Trp Leu Leu Phe Ala Ile Met Trp Trp Leu Val Ala Phe 
                85                  90                  95      


Ala His Gly Asp Ile Tyr Ala Tyr Met Glu Lys Ser Gly Met Glu Lys 
            100                 105                 110         


Ser Gly Leu Glu Ser Thr Val Cys Val Thr Asn Val Arg Ser Phe Thr 
        115                 120                 125             


Ser Ala Phe Leu Phe Ser Ile Glu Val Gln Val Thr Ile Gly Phe Gly 
    130                 135                 140                 


Gly Arg Met Met Thr Glu Glu Cys Pro Leu Ala Ile Thr Val Leu Ile 
145                 150                 155                 160 


Leu Gln Asn Ile Val Gly Leu Ile Ile Asn Ala Val Met Leu Gly Cys 
                165                 170                 175     


Ile Phe Met Lys Thr Ala Gln Ala His Arg Arg Ala Glu Thr Leu Ile 
            180                 185                 190         


Phe Ser Arg His Ala Val Ile Ala Val Arg Asn Gly Lys Leu Cys Phe 
        195                 200                 205             


Met Phe Arg Val Gly Asp Leu Arg Lys Ser Met Ile Ile Ser Ala Ser 
    210                 215                 220                 


Val Arg Ile Gln Val Val Lys Lys Thr Thr Thr Pro Glu Gly Glu Val 
225                 230                 235                 240 


Val Pro Ile His Gln Leu Asp Ile Pro Val Asp Asn Pro Ile Glu Ser 
                245                 250                 255     


Asn Asn Ile Phe Leu Val Ala Pro Leu Ile Ile Cys His Val Ile Asp 
            260                 265                 270         


Lys Arg Ser Pro Leu Tyr Asp Ile Ser Ala Thr Asp Leu Ala Asn Gln 
        275                 280                 285             


Asp Leu Glu Val Ile Val Ile Leu Glu Gly Val Val Glu Thr Thr Gly 
    290                 295                 300                 


Ile Thr Thr Gln Ala Arg Thr Ser Tyr Ile Ala Glu Glu Ile Gln Trp 
305                 310                 315                 320 


Gly His Arg Phe Val Ser Ile Val Thr Glu Glu Glu Gly Val Tyr Ser 
                325                 330                 335     


Val Asp Tyr Ser Lys Phe Gly Asn Thr Val Lys Val Ala Ala Pro Arg 
            340                 345                 350         


Cys Ser Ala Arg Glu Leu Asp Glu Lys Pro Ser Ile Leu Ile Gln Thr 
        355                 360                 365             


Leu Gln Lys Ser Glu Leu Ser His Gln Asn Ser Leu Arg Lys Arg Asn 
    370                 375                 380                 


Ser Met Arg Arg Asn Asn Ser Met Arg Arg Asn Asn Ser Ile Arg Arg 
385                 390                 395                 400 


Asn Asn Ser Ser Leu Met Val Pro Lys Val Gln Phe Met Thr Pro Glu 
                405                 410                 415     


Gly Asn Gln Asn Thr Ser Glu Ser 
            420                 


<210>  3190
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  3190

Met Ala Gln Glu Asn Ala Ala Phe Ser Pro Gly Gln Glu Glu Pro Pro 
1               5                   10                  15      


Arg Arg Arg Gly Arg Gln Arg Tyr Val Glu Lys Asp Gly Arg Cys Asn 
            20                  25                  30          


Val Gln Gln Gly Asn Val Arg Glu Thr Tyr Arg Tyr Leu Thr Asp Leu 
        35                  40                  45              


Phe Thr Thr Leu Val Asp Leu Gln Trp Arg Leu Ser Leu Leu Phe Phe 
    50                  55                  60                  


Val Leu Ala Tyr Ala Leu Thr Trp Leu Phe Phe Gly Ala Ile Trp Trp 
65                  70                  75                  80  


Leu Ile Ala Tyr Gly Arg Gly Asp Leu Glu His Leu Glu Asp Thr Ala 
                85                  90                  95      


Trp Thr Pro Cys Val Asn Asn Leu Asn Gly Phe Val Ala Ala Phe Leu 
            100                 105                 110         


Phe Ser Ile Glu Thr Glu Thr Thr Ile Gly Tyr Gly His Arg Val Ile 
        115                 120                 125             


Thr Asp Gln Cys Pro Glu Gly Ile Val Leu Leu Leu Leu Gln Ala Ile 
    130                 135                 140                 


Leu Gly Ser Met Val Asn Ala Phe Met Val Gly Cys Met Phe Val Lys 
145                 150                 155                 160 


Ile Ser Gln Pro Asn Lys Arg Ala Ala Thr Leu Val Phe Ser Ser His 
                165                 170                 175     


Ala Val Val Ser Leu Arg Asp Gly Arg Leu Cys Leu Met Phe Arg Val 
            180                 185                 190         


Gly Asp Leu Arg Ser Ser His Ile Val Glu Ala Ser Ile Arg Ala Lys 
        195                 200                 205             


Leu Ile Arg Ser Arg Gln Thr Leu Glu Gly Glu Phe Ile Pro Leu His 
    210                 215                 220                 


Gln Thr Asp Leu Ser Val Gly Phe Asp Thr Gly Asp Asp Arg Leu Phe 
225                 230                 235                 240 


Leu Val Ser Pro Leu Val Ile Ser His Glu Ile Asp Ala Ala Ser Pro 
                245                 250                 255     


Phe Trp Glu Ala Ser Arg Arg Ala Leu Glu Arg Asp Asp Phe Glu Ile 
            260                 265                 270         


Val Val Ile Leu Glu Gly Met Val Glu Ala Thr Gly Met Thr Cys Gln 
        275                 280                 285             


Ala Arg Ser Ser Tyr Leu Val Asp Glu Val Leu Trp Gly His Arg Phe 
    290                 295                 300                 


Thr Ser Val Leu Thr Leu Glu Asp Gly Phe Tyr Glu Val Asp Tyr Ala 
305                 310                 315                 320 


Ser Phe His Glu Thr Phe Glu Val Pro Thr Pro Ser Cys Ser Ala Arg 
                325                 330                 335     


Glu Leu Ala Glu Ala Ala Ala Arg Leu Asp Ala His Leu Tyr Trp Ser 
            340                 345                 350         


Ile Pro Ser Arg Leu Asp Glu Lys Val Glu Glu Glu Gly Ala Gly Glu 
        355                 360                 365             


Gly Ala Gly Gly Glu Ala Gly Ala Asp Lys Glu Gln Asn Gly Cys Leu 
    370                 375                 380                 


Pro Pro Pro Glu Ser Glu Ser Lys Val 
385                 390             


<210>  3191
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  3191

Met Ser Leu Glu Gln Arg Ser Leu His Cys Lys Pro Glu Glu Ala Leu 
1               5                   10                  15      


Glu Ala Gln Gln Glu Ala Leu Gly Leu Val Cys Val Gln Ala Ala Thr 
            20                  25                  30          


Ser Ser Ser Ser Pro Leu Val Leu Gly Thr Leu Glu Glu Val Pro Thr 
        35                  40                  45              


Ala Gly Ser Thr Asp Pro Pro Gln Ser Pro Gln Gly Ala Ser Ala Phe 
    50                  55                  60                  


Pro Thr Thr Ile Asn Phe Thr Arg Gln Arg Gln Pro Ser Glu Gly Ser 
65                  70                  75                  80  


Ser Ser Arg Glu Glu Glu Gly Pro Ser Thr Ser Cys Ile Leu Glu Ser 
                85                  90                  95      


Leu Phe Arg Ala Val Ile Thr Lys Lys Val Ala Asp Leu Val Gly Phe 
            100                 105                 110         


Leu Leu Leu Lys Tyr Arg Ala Arg Glu Pro Val Thr Lys Ala Glu Met 
        115                 120                 125             


Leu Glu Ser Val Ile Lys Asn Tyr Lys His Cys Phe Pro Glu Ile Phe 
    130                 135                 140                 


Gly Lys Ala Ser Glu Ser Leu Gln Leu Val Phe Gly Ile Asp Val Lys 
145                 150                 155                 160 


Glu Ala Asp Pro Thr Gly His Ser Tyr Val Leu Val Thr Cys Leu Gly 
                165                 170                 175     


Leu Ser Tyr Asp Gly Leu Leu Gly Asp Asn Gln Ile Met Pro Lys Thr 
            180                 185                 190         


Gly Phe Leu Ile Ile Val Leu Val Met Ile Ala Met Glu Gly Gly His 
        195                 200                 205             


Ala Pro Glu Glu Glu Ile Trp Glu Glu Leu Ser Val Met Glu Val Tyr 
    210                 215                 220                 


Asp Gly Arg Glu His Ser Ala Tyr Gly Glu Pro Arg Lys Leu Leu Thr 
225                 230                 235                 240 


Gln Asp Leu Val Gln Glu Lys Tyr Leu Glu Tyr Arg Gln Val Pro Asp 
                245                 250                 255     


Ser Asp Pro Ala Arg Tyr Glu Phe Leu Trp Gly Pro Arg Ala Leu Ala 
            260                 265                 270         


Glu Thr Ser Tyr Val Lys Val Leu Glu Tyr Val Ile Lys Val Ser Ala 
        275                 280                 285             


Arg Val Arg Phe Phe Phe Pro Ser Leu Arg Glu Ala Ala Leu Arg Glu 
    290                 295                 300                 


Glu Glu Glu Gly Val 
305                 


<210>  3192
<211>  900
<212>  PRT
<213>  Homo sapiens

<400>  3192

Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu 
1               5                   10                  15      


Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr 
            20                  25                  30          


Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val 
        35                  40                  45              


Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Thr Ser Ala 
    50                  55                  60                  


Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu Gln Asp Asp Leu 
65                  70                  75                  80  


Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu Gln Pro Ala Leu 
                85                  90                  95      


Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys Lys Gly Glu Asp 
            100                 105                 110         


Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile Asp His Ser Leu 
        115                 120                 125             


Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr Glu Ser Leu Ala 
    130                 135                 140                 


Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu Gln Asp Pro Ala 
145                 150                 155                 160 


Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp Phe Gln Thr Leu 
                165                 170                 175     


Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr Val Leu Lys Gln 
            180                 185                 190         


Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys Gln Pro Gln Pro 
        195                 200                 205             


Ser Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro Glu Glu Glu Glu 
    210                 215                 220                 


Leu Ala Thr Leu Ser Glu Glu Glu Ile Ala Met Ala Val Thr Ala Trp 
225                 230                 235                 240 


Glu Lys Gly Leu Glu Ser Leu Pro Pro Leu Arg Pro Gln Gln Asn Pro 
                245                 250                 255     


Val Leu Pro Val Ala Gly Glu Arg Asn Val Leu Ile Thr Ser Ala Leu 
            260                 265                 270         


Pro Tyr Val Asn Asn Val Pro His Leu Gly Asn Ile Ile Gly Cys Val 
        275                 280                 285             


Leu Ser Ala Asp Val Phe Ala Arg Tyr Ser Arg Leu Arg Gln Trp Asn 
    290                 295                 300                 


Thr Leu Tyr Leu Cys Gly Thr Asp Glu Tyr Gly Thr Ala Thr Glu Thr 
305                 310                 315                 320 


Lys Ala Leu Glu Glu Gly Leu Thr Pro Gln Glu Ile Cys Asp Lys Tyr 
                325                 330                 335     


His Ile Ile His Ala Asp Ile Tyr Arg Trp Phe Asn Ile Ser Phe Asp 
            340                 345                 350         


Ile Phe Gly Arg Thr Thr Thr Pro Gln Gln Thr Lys Ile Thr Gln Asp 
        355                 360                 365             


Ile Phe Gln Gln Leu Leu Lys Arg Gly Phe Val Leu Gln Asp Thr Val 
    370                 375                 380                 


Glu Gln Leu Arg Cys Glu His Cys Ala Arg Phe Leu Ala Asp Arg Phe 
385                 390                 395                 400 


Val Glu Gly Val Cys Pro Phe Cys Gly Tyr Glu Glu Ala Arg Gly Asp 
                405                 410                 415     


Gln Cys Asp Lys Cys Gly Lys Leu Ile Asn Ala Val Glu Leu Lys Lys 
            420                 425                 430         


Pro Gln Cys Lys Val Cys Arg Ser Cys Pro Val Val Gln Ser Ser Gln 
        435                 440                 445             


His Leu Phe Leu Asp Leu Pro Lys Leu Glu Lys Arg Leu Glu Glu Trp 
    450                 455                 460                 


Leu Gly Arg Thr Leu Pro Gly Ser Asp Trp Thr Pro Asn Ala Gln Phe 
465                 470                 475                 480 


Ile Thr Arg Ser Trp Leu Arg Asp Gly Leu Lys Pro Arg Cys Ile Thr 
                485                 490                 495     


Arg Asp Leu Lys Trp Gly Thr Pro Val Pro Leu Glu Gly Phe Glu Asp 
            500                 505                 510         


Lys Val Phe Tyr Val Trp Phe Asp Ala Thr Ile Gly Tyr Leu Ser Ile 
        515                 520                 525             


Thr Ala Asn Tyr Thr Asp Gln Trp Glu Arg Trp Trp Lys Asn Pro Glu 
    530                 535                 540                 


Gln Val Asp Leu Tyr Gln Phe Met Ala Lys Asp Asn Val Pro Phe His 
545                 550                 555                 560 


Ser Leu Val Phe Pro Cys Ser Ala Leu Gly Ala Glu Asp Asn Tyr Thr 
                565                 570                 575     


Leu Val Ser His Leu Ile Ala Thr Glu Tyr Leu Asn Tyr Glu Asp Gly 
            580                 585                 590         


Lys Phe Ser Lys Ser Arg Gly Val Gly Val Phe Gly Asp Met Ala Gln 
        595                 600                 605             


Asp Thr Gly Ile Pro Ala Asp Ile Trp Arg Phe Tyr Leu Leu Tyr Ile 
    610                 615                 620                 


Arg Pro Glu Gly Gln Asp Ser Ala Phe Ser Trp Thr Asp Leu Leu Leu 
625                 630                 635                 640 


Lys Asn Asn Ser Glu Leu Leu Asn Asn Leu Gly Asn Phe Ile Asn Arg 
                645                 650                 655     


Ala Gly Met Phe Val Ser Lys Phe Phe Gly Gly Tyr Val Pro Glu Met 
            660                 665                 670         


Val Leu Thr Pro Asp Asp Gln Arg Leu Leu Ala His Val Thr Leu Glu 
        675                 680                 685             


Leu Gln His Tyr His Gln Leu Leu Glu Lys Val Arg Ile Arg Asp Ala 
    690                 695                 700                 


Leu Arg Ser Ile Leu Thr Ile Ser Arg His Gly Asn Gln Tyr Ile Gln 
705                 710                 715                 720 


Val Asn Glu Pro Trp Lys Arg Ile Lys Gly Ser Glu Ala Asp Arg Gln 
                725                 730                 735     


Arg Ala Gly Thr Val Thr Gly Leu Ala Val Asn Ile Ala Ala Leu Leu 
            740                 745                 750         


Ser Val Met Leu Gln Pro Tyr Met Pro Thr Val Ser Ala Thr Ile Gln 
        755                 760                 765             


Ala Gln Leu Gln Leu Pro Pro Pro Ala Cys Ser Ile Leu Leu Thr Asn 
    770                 775                 780                 


Phe Leu Cys Thr Leu Pro Ala Gly His Gln Ile Gly Thr Val Ser Pro 
785                 790                 795                 800 


Leu Phe Gln Lys Leu Glu Asn Asp Gln Ile Glu Ser Leu Arg Gln Arg 
                805                 810                 815     


Phe Gly Gly Gly Gln Ala Lys Thr Ser Pro Lys Pro Ala Val Val Glu 
            820                 825                 830         


Thr Val Thr Thr Ala Lys Pro Gln Gln Ile Gln Ala Leu Met Asp Glu 
        835                 840                 845             


Val Thr Lys Gln Gly Asn Ile Val Arg Glu Leu Lys Ala Gln Lys Ala 
    850                 855                 860                 


Asp Lys Asn Glu Val Ala Ala Glu Val Ala Lys Leu Leu Asp Leu Lys 
865                 870                 875                 880 


Lys Gln Leu Ala Val Ala Glu Gly Lys Pro Pro Glu Ala Pro Lys Gly 
                885                 890                 895     


Lys Lys Lys Lys 
            900 


<210>  3193
<211>  1531
<212>  PRT
<213>  Homo sapiens

<400>  3193

Met Ala Leu Arg Gly Phe Cys Ser Ala Asp Gly Ser Asp Pro Leu Trp 
1               5                   10                  15      


Asp Trp Asn Val Thr Trp Asn Thr Ser Asn Pro Asp Phe Thr Lys Cys 
            20                  25                  30          


Phe Gln Asn Thr Val Leu Val Trp Val Pro Cys Phe Tyr Leu Trp Ala 
        35                  40                  45              


Cys Phe Pro Phe Tyr Phe Leu Tyr Leu Ser Arg His Asp Arg Gly Tyr 
    50                  55                  60                  


Ile Gln Met Thr Pro Leu Asn Lys Thr Lys Thr Ala Leu Gly Phe Leu 
65                  70                  75                  80  


Leu Trp Ile Val Cys Trp Ala Asp Leu Phe Tyr Ser Phe Trp Glu Arg 
                85                  90                  95      


Ser Arg Gly Ile Phe Leu Ala Pro Val Phe Leu Val Ser Pro Thr Leu 
            100                 105                 110         


Leu Gly Ile Thr Met Leu Leu Ala Thr Phe Leu Ile Gln Leu Glu Arg 
        115                 120                 125             


Arg Lys Gly Val Gln Ser Ser Gly Ile Met Leu Thr Phe Trp Leu Val 
    130                 135                 140                 


Ala Leu Val Cys Ala Leu Ala Ile Leu Arg Ser Lys Ile Met Thr Ala 
145                 150                 155                 160 


Leu Lys Glu Asp Ala Gln Val Asp Leu Phe Arg Asp Ile Thr Phe Tyr 
                165                 170                 175     


Val Tyr Phe Ser Leu Leu Leu Ile Gln Leu Val Leu Ser Cys Phe Ser 
            180                 185                 190         


Asp Arg Ser Pro Leu Phe Ser Glu Thr Ile His Asp Pro Asn Pro Cys 
        195                 200                 205             


Pro Glu Ser Ser Ala Ser Phe Leu Ser Arg Ile Thr Phe Trp Trp Ile 
    210                 215                 220                 


Thr Gly Leu Ile Val Arg Gly Tyr Arg Gln Pro Leu Glu Gly Ser Asp 
225                 230                 235                 240 


Leu Trp Ser Leu Asn Lys Glu Asp Thr Ser Glu Gln Val Val Pro Val 
                245                 250                 255     


Leu Val Lys Asn Trp Lys Lys Glu Cys Ala Lys Thr Arg Lys Gln Pro 
            260                 265                 270         


Val Lys Val Val Tyr Ser Ser Lys Asp Pro Ala Gln Pro Lys Glu Ser 
        275                 280                 285             


Ser Lys Val Asp Ala Asn Glu Glu Val Glu Ala Leu Ile Val Lys Ser 
    290                 295                 300                 


Pro Gln Lys Glu Trp Asn Pro Ser Leu Phe Lys Val Leu Tyr Lys Thr 
305                 310                 315                 320 


Phe Gly Pro Tyr Phe Leu Met Ser Phe Phe Phe Lys Ala Ile His Asp 
                325                 330                 335     


Leu Met Met Phe Ser Gly Pro Gln Ile Leu Lys Leu Leu Ile Lys Phe 
            340                 345                 350         


Val Asn Asp Thr Lys Ala Pro Asp Trp Gln Gly Tyr Phe Tyr Thr Val 
        355                 360                 365             


Leu Leu Phe Val Thr Ala Cys Leu Gln Thr Leu Val Leu His Gln Tyr 
    370                 375                 380                 


Phe His Ile Cys Phe Val Ser Gly Met Arg Ile Lys Thr Ala Val Ile 
385                 390                 395                 400 


Gly Ala Val Tyr Arg Lys Ala Leu Val Ile Thr Asn Ser Ala Arg Lys 
                405                 410                 415     


Ser Ser Thr Val Gly Glu Ile Val Asn Leu Met Ser Val Asp Ala Gln 
            420                 425                 430         


Arg Phe Met Asp Leu Ala Thr Tyr Ile Asn Met Ile Trp Ser Ala Pro 
        435                 440                 445             


Leu Gln Val Ile Leu Ala Leu Tyr Leu Leu Trp Leu Asn Leu Gly Pro 
    450                 455                 460                 


Ser Val Leu Ala Gly Val Ala Val Met Val Leu Met Val Pro Val Asn 
465                 470                 475                 480 


Ala Val Met Ala Met Lys Thr Lys Thr Tyr Gln Val Ala His Met Lys 
                485                 490                 495     


Ser Lys Asp Asn Arg Ile Lys Leu Met Asn Glu Ile Leu Asn Gly Ile 
            500                 505                 510         


Lys Val Leu Lys Leu Tyr Ala Trp Glu Leu Ala Phe Lys Asp Lys Val 
        515                 520                 525             


Leu Ala Ile Arg Gln Glu Glu Leu Lys Val Leu Lys Lys Ser Ala Tyr 
    530                 535                 540                 


Leu Ser Ala Val Gly Thr Phe Thr Trp Val Cys Thr Pro Phe Leu Val 
545                 550                 555                 560 


Ala Leu Cys Thr Phe Ala Val Tyr Val Thr Ile Asp Glu Asn Asn Ile 
                565                 570                 575     


Leu Asp Ala Gln Thr Ala Phe Val Ser Leu Ala Leu Phe Asn Ile Leu 
            580                 585                 590         


Arg Phe Pro Leu Asn Ile Leu Pro Met Val Ile Ser Ser Ile Val Gln 
        595                 600                 605             


Ala Ser Val Ser Leu Lys Arg Leu Arg Ile Phe Leu Ser His Glu Glu 
    610                 615                 620                 


Leu Glu Pro Asp Ser Ile Glu Arg Arg Pro Val Lys Asp Gly Gly Gly 
625                 630                 635                 640 


Thr Asn Ser Ile Thr Val Arg Asn Ala Thr Phe Thr Trp Ala Arg Ser 
                645                 650                 655     


Asp Pro Pro Thr Leu Asn Gly Ile Thr Phe Ser Ile Pro Glu Gly Ala 
            660                 665                 670         


Leu Val Ala Val Val Gly Gln Val Gly Cys Gly Lys Ser Ser Leu Leu 
        675                 680                 685             


Ser Ala Leu Leu Ala Glu Met Asp Lys Val Glu Gly His Val Ala Ile 
    690                 695                 700                 


Lys Gly Ser Val Ala Tyr Val Pro Gln Gln Ala Trp Ile Gln Asn Asp 
705                 710                 715                 720 


Ser Leu Arg Glu Asn Ile Leu Phe Gly Cys Gln Leu Glu Glu Pro Tyr 
                725                 730                 735     


Tyr Arg Ser Val Ile Gln Ala Cys Ala Leu Leu Pro Asp Leu Glu Ile 
            740                 745                 750         


Leu Pro Ser Gly Asp Arg Thr Glu Ile Gly Glu Lys Gly Val Asn Leu 
        755                 760                 765             


Ser Gly Gly Gln Lys Gln Arg Val Ser Leu Ala Arg Ala Val Tyr Ser 
    770                 775                 780                 


Asn Ala Asp Ile Tyr Leu Phe Asp Asp Pro Leu Ser Ala Val Asp Ala 
785                 790                 795                 800 


His Val Gly Lys His Ile Phe Glu Asn Val Ile Gly Pro Lys Gly Met 
                805                 810                 815     


Leu Lys Asn Lys Thr Arg Ile Leu Val Thr His Ser Met Ser Tyr Leu 
            820                 825                 830         


Pro Gln Val Asp Val Ile Ile Val Met Ser Gly Gly Lys Ile Ser Glu 
        835                 840                 845             


Met Gly Ser Tyr Gln Glu Leu Leu Ala Arg Asp Gly Ala Phe Ala Glu 
    850                 855                 860                 


Phe Leu Arg Thr Tyr Ala Ser Thr Glu Gln Glu Gln Asp Ala Glu Glu 
865                 870                 875                 880 


Asn Gly Val Thr Gly Val Ser Gly Pro Gly Lys Glu Ala Lys Gln Met 
                885                 890                 895     


Glu Asn Gly Met Leu Val Thr Asp Ser Ala Gly Lys Gln Leu Gln Arg 
            900                 905                 910         


Gln Leu Ser Ser Ser Ser Ser Tyr Ser Gly Asp Ile Ser Arg His His 
        915                 920                 925             


Asn Ser Thr Ala Glu Leu Gln Lys Ala Glu Ala Lys Lys Glu Glu Thr 
    930                 935                 940                 


Trp Lys Leu Met Glu Ala Asp Lys Ala Gln Thr Gly Gln Val Lys Leu 
945                 950                 955                 960 


Ser Val Tyr Trp Asp Tyr Met Lys Ala Ile Gly Leu Phe Ile Ser Phe 
                965                 970                 975     


Leu Ser Ile Phe Leu Phe Met Cys Asn His Val Ser Ala Leu Ala Ser 
            980                 985                 990         


Asn Tyr Trp Leu Ser Leu Trp Thr  Asp Asp Pro Ile Val  Asn Gly Thr 
        995                 1000                 1005             


Gln Glu  His Thr Lys Val Arg  Leu Ser Val Tyr Gly  Ala Leu Gly 
    1010                 1015                 1020             


Ile Ser  Gln Gly Ile Ala Val  Phe Gly Tyr Ser Met  Ala Val Ser 
    1025                 1030                 1035             


Ile Gly  Gly Ile Leu Ala Ser  Arg Cys Leu His Val  Asp Leu Leu 
    1040                 1045                 1050             


His Ser  Ile Leu Arg Ser Pro  Met Ser Phe Phe Glu  Arg Thr Pro 
    1055                 1060                 1065             


Ser Gly  Asn Leu Val Asn Arg  Phe Ser Lys Glu Leu  Asp Thr Val 
    1070                 1075                 1080             


Asp Ser  Met Ile Pro Glu Val  Ile Lys Met Phe Met  Gly Ser Leu 
    1085                 1090                 1095             


Phe Asn  Val Ile Gly Ala Cys  Ile Val Ile Leu Leu  Ala Thr Pro 
    1100                 1105                 1110             


Ile Ala  Ala Ile Ile Ile Pro  Pro Leu Gly Leu Ile  Tyr Phe Phe 
    1115                 1120                 1125             


Val Gln  Arg Phe Tyr Val Ala  Ser Ser Arg Gln Leu  Lys Arg Leu 
    1130                 1135                 1140             


Glu Ser  Val Ser Arg Ser Pro  Val Tyr Ser His Phe  Asn Glu Thr 
    1145                 1150                 1155             


Leu Leu  Gly Val Ser Val Ile  Arg Ala Phe Glu Glu  Gln Glu Arg 
    1160                 1165                 1170             


Phe Ile  His Gln Ser Asp Leu  Lys Val Asp Glu Asn  Gln Lys Ala 
    1175                 1180                 1185             


Tyr Tyr  Pro Ser Ile Val Ala  Asn Arg Trp Leu Ala  Val Arg Leu 
    1190                 1195                 1200             


Glu Cys  Val Gly Asn Cys Ile  Val Leu Phe Ala Ala  Leu Phe Ala 
    1205                 1210                 1215             


Val Ile  Ser Arg His Ser Leu  Ser Ala Gly Leu Val  Gly Leu Ser 
    1220                 1225                 1230             


Val Ser  Tyr Ser Leu Gln Val  Thr Thr Tyr Leu Asn  Trp Leu Val 
    1235                 1240                 1245             


Arg Met  Ser Ser Glu Met Glu  Thr Asn Ile Val Ala  Val Glu Arg 
    1250                 1255                 1260             


Leu Lys  Glu Tyr Ser Glu Thr  Glu Lys Glu Ala Pro  Trp Gln Ile 
    1265                 1270                 1275             


Gln Glu  Thr Ala Pro Pro Ser  Ser Trp Pro Gln Val  Gly Arg Val 
    1280                 1285                 1290             


Glu Phe  Arg Asn Tyr Cys Leu  Arg Tyr Arg Glu Asp  Leu Asp Phe 
    1295                 1300                 1305             


Val Leu  Arg His Ile Asn Val  Thr Ile Asn Gly Gly  Glu Lys Val 
    1310                 1315                 1320             


Gly Ile  Val Gly Arg Thr Gly  Ala Gly Lys Ser Ser  Leu Thr Leu 
    1325                 1330                 1335             


Gly Leu  Phe Arg Ile Asn Glu  Ser Ala Glu Gly Glu  Ile Ile Ile 
    1340                 1345                 1350             


Asp Gly  Ile Asn Ile Ala Lys  Ile Gly Leu His Asp  Leu Arg Phe 
    1355                 1360                 1365             


Lys Ile  Thr Ile Ile Pro Gln  Asp Pro Val Leu Phe  Ser Gly Ser 
    1370                 1375                 1380             


Leu Arg  Met Asn Leu Asp Pro  Phe Ser Gln Tyr Ser  Asp Glu Glu 
    1385                 1390                 1395             


Val Trp  Thr Ser Leu Glu Leu  Ala His Leu Lys Asp  Phe Val Ser 
    1400                 1405                 1410             


Ala Leu  Pro Asp Lys Leu Asp  His Glu Cys Ala Glu  Gly Gly Glu 
    1415                 1420                 1425             


Asn Leu  Ser Val Gly Gln Arg  Gln Leu Val Cys Leu  Ala Arg Ala 
    1430                 1435                 1440             


Leu Leu  Arg Lys Thr Lys Ile  Leu Val Leu Asp Glu  Ala Thr Ala 
    1445                 1450                 1455             


Ala Val  Asp Leu Glu Thr Asp  Asp Leu Ile Gln Ser  Thr Ile Arg 
    1460                 1465                 1470             


Thr Gln  Phe Glu Asp Cys Thr  Val Leu Thr Ile Ala  His Arg Leu 
    1475                 1480                 1485             


Asn Thr  Ile Met Asp Tyr Thr  Arg Val Ile Val Leu  Asp Lys Gly 
    1490                 1495                 1500             


Glu Ile  Gln Glu Tyr Gly Ala  Pro Ser Asp Leu Leu  Gln Gln Arg 
    1505                 1510                 1515             


Gly Leu  Phe Tyr Ser Met Ala  Lys Asp Ala Gly Leu  Val 
    1520                 1525                 1530     


<210>  3194
<211>  49
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<400>  3194

Asx Glu Thr Ala Ser Asx Cys Met Pro Leu Glu Xaa Ser Asx Asn Ile 
1               5                   10                  15      


Thr Met Ile Thr Cys His Asn Asp Arg Ile Ala Leu Ile Ser Phe Arg 
            20                  25                  30          


Met Pro Arg Glu Cys Arg Ser Arg His Met Ser Ala Pro Ile Glu Asn 
        35                  40                  45              


Ser 
    


<210>  3195
<211>  1183
<212>  PRT
<213>  Homo sapiens

<400>  3195

Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg 
1               5                   10                  15      


Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val 
            20                  25                  30          


Pro Leu Asp Leu Val Gln Pro Pro Thr Ile Thr Gln Gln Ser Pro Lys 
        35                  40                  45              


Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile Val Ile Gln Cys Glu Ala 
    50                  55                  60                  


Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp Thr Arg Asn Gly Thr His 
65                  70                  75                  80  


Phe Asp Ile Asp Lys Asp Pro Leu Val Thr Met Lys Pro Gly Thr Gly 
                85                  90                  95      


Thr Leu Ile Ile Asn Ile Met Ser Glu Gly Lys Ala Glu Thr Tyr Glu 
            100                 105                 110         


Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu Arg Gly Ala Ala Val Ser 
        115                 120                 125             


Asn Asn Ile Val Val Arg Pro Ser Arg Ser Pro Leu Trp Thr Lys Glu 
    130                 135                 140                 


Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly Gln Ser Leu Val Leu Pro 
145                 150                 155                 160 


Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro Ile Ile Phe Trp Met Asp 
                165                 170                 175     


Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu Arg Val Ser Gln Gly Leu 
            180                 185                 190         


Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu Pro Glu Asp Thr Arg Glu 
        195                 200                 205             


Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His Thr Gln Thr Ile Gln Gln 
    210                 215                 220                 


Lys Gln Pro Ile Ser Val Lys Val Ile Ser Val Asp Glu Leu Asn Asp 
225                 230                 235                 240 


Thr Ile Ala Ala Asn Leu Ser Asp Thr Glu Phe Tyr Gly Ala Lys Ser 
                245                 250                 255     


Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr Pro Glu Gly Asn Ala Ser 
            260                 265                 270         


Asn Lys Glu Glu Leu Arg Gly Asn Val Leu Ser Leu Glu Cys Ile Ala 
        275                 280                 285             


Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp Ala Lys Glu Asp Gly Met 
    290                 295                 300                 


Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn Phe Glu Lys Thr Leu Gln 
305                 310                 315                 320 


Ile Ile His Val Ser Glu Ala Asp Ser Gly Asn Tyr Gln Cys Ile Ala 
                325                 330                 335     


Lys Asn Ala Leu Gly Ala Ile His His Thr Ile Ser Val Arg Val Lys 
            340                 345                 350         


Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln Asn Leu Val Leu Ser Pro 
        355                 360                 365             


Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala Asn Gly Asn Pro Lys Pro 
    370                 375                 380                 


Arg Ile Ser Trp Leu Thr Asn Gly Val Pro Ile Glu Ile Ala Pro Asp 
385                 390                 395                 400 


Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr Ile Ile Phe Ser Asn Val 
                405                 410                 415     


Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys Asn Ala Ser Asn Glu Tyr 
            420                 425                 430         


Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn Val Leu Ala Glu Pro Pro 
        435                 440                 445             


Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr Gln Val Ile Ala Asn Arg 
    450                 455                 460                 


Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly Ser Pro Leu Pro Thr Ile 
465                 470                 475                 480 


Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala Leu His Glu Asp Ile Tyr 
                485                 490                 495     


Val Leu His Glu Asn Gly Thr Leu Glu Ile Pro Val Ala Gln Lys Asp 
            500                 505                 510         


Ser Thr Gly Thr Tyr Thr Cys Val Ala Arg Asn Lys Leu Gly Met Ala 
        515                 520                 525             


Lys Asn Glu Val His Leu Glu Ile Lys Asp Pro Thr Trp Ile Val Lys 
    530                 535                 540                 


Gln Pro Glu Tyr Ala Val Val Gln Arg Gly Ser Met Val Ser Phe Glu 
545                 550                 555                 560 


Cys Lys Val Lys His Asp His Thr Leu Ser Leu Thr Val Leu Trp Leu 
                565                 570                 575     


Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu Arg Phe Thr Val Asp Lys 
            580                 585                 590         


Asp His Leu Val Val Ala Asp Val Ser Asp Asp Asp Ser Gly Thr Tyr 
        595                 600                 605             


Thr Cys Val Ala Asn Thr Thr Leu Asp Ser Val Ser Ala Ser Ala Val 
    610                 615                 620                 


Leu Ser Val Val Asp Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr 
625                 630                 635                 640 


Asp Gln Leu Asp Lys Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp 
                645                 650                 655     


Asn Asn Ser Pro Ile Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met 
            660                 665                 670         


His Lys Pro Gly Leu Trp His His Gln Thr Glu Val Ser Gly Thr Gln 
        675                 680                 685             


Thr Thr Ala Gln Leu Lys Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg 
    690                 695                 700                 


Val Met Ala Val Asn Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser 
705                 710                 715                 720 


Glu Gln Tyr Leu Thr Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala 
                725                 730                 735     


Val Glu Gly Leu Gly Ser Glu Pro Asp Asn Leu Val Ile Thr Trp Lys 
            740                 745                 750         


Pro Leu Asn Gly Phe Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val 
        755                 760                 765             


Ser Trp Arg Gln Lys Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val 
    770                 775                 780                 


Ala Asn Val Ser Lys Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro 
785                 790                 795                 800 


Tyr Leu Ile Lys Val Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu 
                805                 810                 815     


Pro Ala Val Val Met Gly His Ser Gly Glu Asp Leu Pro Met Val Ala 
            820                 825                 830         


Pro Gly Asn Val Arg Val Asn Val Val Asn Ser Thr Leu Ala Glu Val 
        835                 840                 845             


His Trp Asp Pro Val Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly 
    850                 855                 860                 


Tyr Arg Ile Tyr Tyr Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg 
865                 870                 875                 880 


Arg His Ile Glu Lys Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His 
                885                 890                 895     


Gly Met Leu Pro Gly Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val 
            900                 905                 910         


Arg Val Val Asn Gly Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val 
        915                 920                 925             


Phe Asn Thr Pro Glu Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile 
    930                 935                 940                 


Val Asn Pro Thr Leu Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser 
945                 950                 955                 960 


His Pro Asn Gly Ile Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile 
                965                 970                 975     


Asn Ser Thr His Glu Leu Gly Pro Leu Val Asp Leu Lys Ile Pro Ala 
            980                 985                 990         


Asn Lys Thr Arg Trp Thr Leu Lys  Asn Leu Asn Phe Ser  Thr Arg Tyr 
        995                 1000                 1005             


Lys Phe  Tyr Phe Tyr Ala Gln  Thr Ser Ala Gly Ser  Gly Ser Gln 
    1010                 1015                 1020             


Ile Thr  Glu Glu Ala Val Thr  Thr Val Asp Glu Ala  Met Ala Ser 
    1025                 1030                 1035             


Arg Gln  Val Asp Ile Ala Thr  Gln Gly Trp Phe Ile  Gly Leu Met 
    1040                 1045                 1050             


Cys Ala  Val Ala Leu Leu Ile  Leu Ile Leu Leu Ile  Val Cys Phe 
    1055                 1060                 1065             


Ile Arg  Arg Asn Lys Gly Gly  Lys Tyr Pro Val Lys  Glu Lys Glu 
    1070                 1075                 1080             


Asp Ala  His Ala Asp Pro Glu  Ile Gln Pro Met Lys  Glu Asp Asp 
    1085                 1090                 1095             


Gly Thr  Phe Gly Glu Tyr Ser  Asp Ala Glu Asp His  Lys Pro Leu 
    1100                 1105                 1110             


Lys Lys  Gly Ser Arg Thr Pro  Ser Asp Arg Thr Val  Lys Lys Glu 
    1115                 1120                 1125             


Asp Ser  Asp Asp Ser Leu Val  Asp Tyr Gly Glu Gly  Val Asn Gly 
    1130                 1135                 1140             


Gln Phe  Asn Glu Asp Gly Ser  Phe Ile Gly Gln Tyr  Ser Gly Lys 
    1145                 1150                 1155             


Lys Glu  Lys Glu Pro Ala Glu  Gly Asn Glu Ser Ser  Glu Ala Pro 
    1160                 1165                 1170             


Ser Pro  Val Asn Ala Met Asn  Ser Phe Val 
    1175                 1180             


<210>  3196
<211>  937
<212>  PRT
<213>  Homo sapiens

<400>  3196

Met His Arg Pro Arg Arg Arg Gly Thr Arg Pro Pro Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Leu Ala Ala Arg Gly Ala Ala Ala Gln Glu Thr 
            20                  25                  30          


Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser Trp Asn Ile 
        35                  40                  45              


Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp Glu Pro Met 
    50                  55                  60                  


Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu His Cys Lys 
65                  70                  75                  80  


Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys Asn Asp Ala 
                85                  90                  95      


Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser Thr Ile Tyr 
            100                 105                 110         


Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp Thr Gly Tyr 
        115                 120                 125             


Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser Ser Thr Gly 
    130                 135                 140                 


Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser Pro Gly Tyr 
145                 150                 155                 160 


Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr Arg Gly Ile 
                165                 170                 175     


Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met Glu Ser Leu 
            180                 185                 190         


His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala Phe Thr Met 
        195                 200                 205             


Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln Phe Ala Ile 
    210                 215                 220                 


Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu Thr Ser Ser 
225                 230                 235                 240 


Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu Ile Leu Glu 
                245                 250                 255     


Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser Asn Pro Met 
            260                 265                 270         


Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu Pro Gln Pro 
        275                 280                 285             


Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile Pro Met Ala 
    290                 295                 300                 


Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr Gly Val Asp 
305                 310                 315                 320 


Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln Cys Gln Pro 
                325                 330                 335     


Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala Leu Arg Phe 
            340                 345                 350         


Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro Gly Asn Gln 
        355                 360                 365             


Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp 
    370                 375                 380                 


Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys Glu Lys Asn 
385                 390                 395                 400 


Lys Met Glu Ile Leu Tyr Ile Leu Val Pro Ser Val Ala Ile Pro Leu 
                405                 410                 415     


Ala Ile Ala Leu Leu Phe Phe Phe Ile Cys Val Cys Arg Asn Asn Gln 
            420                 425                 430         


Lys Ser Ser Ser Ala Pro Val Gln Arg Gln Pro Lys His Val Arg Gly 
        435                 440                 445             


Gln Asn Val Glu Met Ser Met Leu Asn Ala Tyr Lys Pro Lys Ser Lys 
    450                 455                 460                 


Ala Lys Glu Leu Pro Leu Ser Ala Val Arg Phe Met Glu Glu Leu Gly 
465                 470                 475                 480 


Glu Cys Ala Phe Gly Lys Ile Tyr Lys Gly His Leu Tyr Leu Pro Gly 
                485                 490                 495     


Met Asp His Ala Gln Leu Val Ala Ile Lys Thr Leu Lys Asp Tyr Asn 
            500                 505                 510         


Asn Pro Gln Gln Trp Thr Glu Phe Gln Gln Glu Ala Ser Leu Met Ala 
        515                 520                 525             


Glu Leu His His Pro Asn Ile Val Cys Leu Leu Gly Ala Val Thr Gln 
    530                 535                 540                 


Glu Gln Pro Val Cys Met Leu Phe Glu Tyr Ile Asn Gln Gly Asp Leu 
545                 550                 555                 560 


His Glu Phe Leu Ile Met Arg Ser Pro His Ser Asp Val Gly Cys Ser 
                565                 570                 575     


Ser Asp Glu Asp Gly Thr Val Lys Ser Ser Leu Asp His Gly Asp Phe 
            580                 585                 590         


Leu His Ile Ala Ile Gln Ile Ala Ala Gly Met Glu Tyr Leu Ser Ser 
        595                 600                 605             


His Phe Phe Val His Lys Asp Leu Ala Ala Arg Asn Ile Leu Ile Gly 
    610                 615                 620                 


Glu Gln Leu His Val Lys Ile Ser Asp Leu Gly Leu Ser Arg Glu Ile 
625                 630                 635                 640 


Tyr Ser Ala Asp Tyr Tyr Arg Val Gln Ser Lys Ser Leu Leu Pro Ile 
                645                 650                 655     


Arg Trp Met Pro Pro Glu Ala Ile Met Tyr Gly Lys Phe Ser Ser Asp 
            660                 665                 670         


Ser Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Ile Phe Ser Phe 
        675                 680                 685             


Gly Leu Gln Pro Tyr Tyr Gly Phe Ser Asn Gln Glu Val Ile Glu Met 
    690                 695                 700                 


Val Arg Lys Arg Gln Leu Leu Pro Cys Ser Glu Asp Cys Pro Pro Arg 
705                 710                 715                 720 


Met Tyr Ser Leu Met Thr Glu Cys Trp Asn Glu Ile Pro Ser Arg Arg 
                725                 730                 735     


Pro Arg Phe Lys Asp Ile His Val Arg Leu Arg Ser Trp Glu Gly Leu 
            740                 745                 750         


Ser Ser His Thr Ser Ser Thr Thr Pro Ser Gly Gly Asn Ala Thr Thr 
        755                 760                 765             


Gln Thr Thr Ser Leu Ser Ala Ser Pro Val Ser Asn Leu Ser Asn Pro 
    770                 775                 780                 


Arg Tyr Pro Asn Tyr Met Phe Pro Ser Gln Gly Ile Thr Pro Gln Gly 
785                 790                 795                 800 


Gln Ile Ala Gly Phe Ile Gly Pro Pro Ile Pro Gln Asn Gln Arg Phe 
                805                 810                 815     


Ile Pro Ile Asn Gly Tyr Pro Ile Pro Pro Gly Tyr Ala Ala Phe Pro 
            820                 825                 830         


Ala Ala His Tyr Gln Pro Thr Gly Pro Pro Arg Val Ile Gln His Cys 
        835                 840                 845             


Pro Pro Pro Lys Ser Arg Ser Pro Ser Ser Ala Ser Gly Ser Thr Ser 
    850                 855                 860                 


Thr Gly His Val Thr Ser Leu Pro Ser Ser Gly Ser Asn Gln Glu Ala 
865                 870                 875                 880 


Asn Ile Pro Leu Leu Pro His Met Ser Ile Pro Asn His Pro Gly Gly 
                885                 890                 895     


Met Gly Ile Thr Val Phe Gly Asn Lys Ser Gln Lys Pro Tyr Lys Ile 
            900                 905                 910         


Asp Ser Lys Gln Ala Ser Leu Leu Gly Asp Ala Asn Ile His Gly His 
        915                 920                 925             


Thr Glu Ser Met Ile Ser Ala Glu Leu 
    930                 935         


<210>  3197
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  3197

Met Val Thr Trp Leu Tyr Arg Phe Leu Pro Thr Ser Asn Met Ala Ala 
1               5                   10                  15      


Lys Leu Arg Ser Leu Leu Pro Pro Asp Leu Arg Leu Gln Phe Trp Leu 
            20                  25                  30          


His Ala Arg Leu Gln Lys Cys Phe Leu Ser Arg Gly Cys Gly Ser Tyr 
        35                  40                  45              


Cys Ala Gly Ala Lys Ala Ser Pro Leu Pro Gly Lys Met Ala Met Gly 
    50                  55                  60                  


Leu Met Cys Gly Arg Arg Glu Leu Leu Arg Leu Leu Gln Ser Gly Arg 
65                  70                  75                  80  


Arg Val His Ser Val Ala Gly Pro Ser Gln Trp Leu Gly Lys Pro Leu 
                85                  90                  95      


Thr Thr Arg Leu Leu Phe Pro Ala Ala Pro Cys Cys Cys Arg Pro His 
            100                 105                 110         


Tyr Leu Phe Leu Ala Ala Ser Gly Pro Arg Ser Leu Ser Thr Ser Ala 
        115                 120                 125             


Ile Ser Phe Ala Glu Val Gln Val Gln Ala Pro Pro Val Val Ala Ala 
    130                 135                 140                 


Thr Pro Ser Pro Thr Ala Val Pro Glu Val Ala Ser Gly Glu Thr Ala 
145                 150                 155                 160 


Asp Val Val Gln Thr Ala Ala Glu Gln Ser Phe Ala Glu Leu Gly Leu 
                165                 170                 175     


Gly Ser Tyr Thr Pro Val Gly Leu Ile Gln Asn Leu Leu Glu Phe Met 
            180                 185                 190         


His Val Asp Leu Gly Leu Pro Trp Trp Gly Ala Ile Ala Ala Cys Thr 
        195                 200                 205             


Val Phe Ala Arg Cys Leu Ile Phe Pro Leu Ile Val Thr Gly Gln Arg 
    210                 215                 220                 


Glu Ala Ala Arg Ile His Asn His Leu Pro Glu Ile Gln Lys Phe Ser 
225                 230                 235                 240 


Ser Arg Ile Arg Glu Ala Lys Leu Ala Gly Asp His Ile Glu Tyr Tyr 
                245                 250                 255     


Lys Ala Ser Ser Glu Met Ala Leu Tyr Gln Lys Lys His Gly Ile Lys 
            260                 265                 270         


Leu Tyr Lys Pro Leu Ile Leu Pro Val Thr Gln Ala Pro Ile Phe Ile 
        275                 280                 285             


Ser Phe Phe Ile Ala Leu Arg Glu Met Ala Asn Leu Pro Val Pro Ser 
    290                 295                 300                 


Leu Gln Thr Gly Gly Leu Trp Trp Phe Gln Asp Leu Thr Val Ser Asp 
305                 310                 315                 320 


Pro Ile Tyr Ile Leu Pro Leu Ala Val Thr Ala Thr Met Trp Ala Val 
                325                 330                 335     


Leu Glu Leu Gly Ala Glu Thr Gly Val Gln Ser Ser Asp Leu Gln Trp 
            340                 345                 350         


Met Arg Asn Val Ile Arg Met Met Pro Leu Ile Thr Leu Pro Ile Thr 
        355                 360                 365             


Met His Phe Pro Thr Ala Val Phe Met Tyr Trp Leu Ser Ser Asn Leu 
    370                 375                 380                 


Phe Ser Leu Val Gln Val Ser Cys Leu Arg Ile Pro Ala Val Arg Thr 
385                 390                 395                 400 


Val Leu Lys Ile Pro Gln Arg Val Val His Asp Leu Asp Lys Leu Pro 
                405                 410                 415     


Pro Arg Glu Gly Phe Leu Glu Ser Phe Lys Lys Gly Trp Lys Asn Ala 
            420                 425                 430         


Glu Met Thr Arg Gln Leu Arg Glu Arg Glu Gln Arg Met Arg Asn Gln 
        435                 440                 445             


Leu Glu Leu Ala Ala Arg Gly Pro Leu Arg Gln Thr Phe Thr His Asn 
    450                 455                 460                 


Pro Leu Leu Gln Pro Gly Lys Asp Asn Pro Pro Asn Ile Pro Ser Ser 
465                 470                 475                 480 


Ser Ser Lys Pro Lys Ser Lys Tyr Pro Trp His Asp Thr Leu Gly 
                485                 490                 495 


<210>  3198
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  3198

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  3199
<211>  875
<212>  PRT
<213>  Homo sapiens

<400>  3199

Met Glu Ser Thr Leu Thr Leu Ala Thr Glu Gln Pro Val Lys Lys Asn 
1               5                   10                  15      


Thr Leu Lys Lys Tyr Lys Ile Ala Cys Ile Val Leu Leu Ala Leu Leu 
            20                  25                  30          


Val Ile Met Ser Leu Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys Leu 
        35                  40                  45              


Glu Lys Gln Gly Ser Cys Arg Lys Lys Cys Phe Asp Ala Ser Phe Arg 
    50                  55                  60                  


Gly Leu Glu Asn Cys Arg Cys Asp Val Ala Cys Lys Asp Arg Gly Asp 
65                  70                  75                  80  


Cys Cys Trp Asp Phe Glu Asp Thr Cys Val Glu Ser Thr Arg Ile Trp 
                85                  90                  95      


Met Cys Asn Lys Phe Arg Cys Gly Glu Thr Arg Leu Glu Ala Ser Leu 
            100                 105                 110         


Cys Ser Cys Ser Asp Asp Cys Leu Gln Arg Lys Asp Cys Cys Ala Asp 
        115                 120                 125             


Tyr Lys Ser Val Cys Gln Gly Glu Thr Ser Trp Leu Glu Glu Asn Cys 
    130                 135                 140                 


Asp Thr Ala Gln Gln Ser Gln Cys Pro Glu Gly Phe Asp Leu Pro Pro 
145                 150                 155                 160 


Val Ile Leu Phe Ser Met Asp Gly Phe Arg Ala Glu Tyr Leu Tyr Thr 
                165                 170                 175     


Trp Asp Thr Leu Met Pro Asn Ile Asn Lys Leu Lys Thr Cys Gly Ile 
            180                 185                 190         


His Ser Lys Tyr Met Arg Ala Met Tyr Pro Thr Lys Thr Phe Pro Asn 
        195                 200                 205             


His Tyr Thr Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly Ile Ile 
    210                 215                 220                 


Asp Asn Asn Met Tyr Asp Val Asn Leu Asn Lys Asn Phe Ser Leu Ser 
225                 230                 235                 240 


Ser Lys Glu Gln Asn Asn Pro Ala Trp Trp His Gly Gln Pro Met Trp 
                245                 250                 255     


Leu Thr Ala Met Tyr Gln Gly Leu Lys Ala Ala Thr Tyr Phe Trp Pro 
            260                 265                 270         


Gly Ser Glu Val Ala Ile Asn Gly Ser Phe Pro Ser Ile Tyr Met Pro 
        275                 280                 285             


Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Ser Thr Leu Leu Lys 
    290                 295                 300                 


Trp Leu Asp Leu Pro Lys Ala Glu Arg Pro Arg Phe Tyr Thr Met Tyr 
305                 310                 315                 320 


Phe Glu Glu Pro Asp Ser Ser Gly His Ala Gly Gly Pro Val Ser Ala 
                325                 330                 335     


Arg Val Ile Lys Ala Leu Gln Val Val Asp His Ala Phe Gly Met Leu 
            340                 345                 350         


Met Glu Gly Leu Lys Gln Arg Asn Leu His Asn Cys Val Asn Ile Ile 
        355                 360                 365             


Leu Leu Ala Asp His Gly Met Asp Gln Thr Tyr Cys Asn Lys Met Glu 
    370                 375                 380                 


Tyr Met Thr Asp Tyr Phe Pro Arg Ile Asn Phe Phe Tyr Met Tyr Glu 
385                 390                 395                 400 


Gly Pro Ala Pro Arg Ile Arg Ala His Asn Ile Pro His Asp Phe Phe 
                405                 410                 415     


Ser Phe Asn Ser Glu Glu Ile Val Arg Asn Leu Ser Cys Arg Lys Pro 
            420                 425                 430         


Asp Gln His Phe Lys Pro Tyr Leu Thr Pro Asp Leu Pro Lys Arg Leu 
        435                 440                 445             


His Tyr Ala Lys Asn Val Arg Ile Asp Lys Val His Leu Phe Val Asp 
    450                 455                 460                 


Gln Gln Trp Leu Ala Val Arg Ser Lys Ser Asn Thr Asn Cys Gly Gly 
465                 470                 475                 480 


Gly Asn His Gly Tyr Asn Asn Glu Phe Arg Ser Met Glu Ala Ile Phe 
                485                 490                 495     


Leu Ala His Gly Pro Ser Phe Lys Glu Lys Thr Glu Val Glu Pro Phe 
            500                 505                 510         


Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu Arg Ile Gln 
        515                 520                 525             


Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn His Leu Leu Lys 
    530                 535                 540                 


Val Pro Phe Tyr Glu Pro Ser His Ala Glu Glu Val Ser Lys Phe Ser 
545                 550                 555                 560 


Val Cys Gly Phe Ala Asn Pro Leu Pro Thr Glu Ser Leu Asp Cys Phe 
                565                 570                 575     


Cys Pro His Leu Gln Asn Ser Thr Gln Leu Glu Gln Val Asn Gln Met 
            580                 585                 590         


Leu Asn Leu Thr Gln Glu Glu Ile Thr Ala Thr Val Lys Val Asn Leu 
        595                 600                 605             


Pro Phe Gly Arg Pro Arg Val Leu Gln Lys Asn Val Asp His Cys Leu 
    610                 615                 620                 


Leu Tyr His Arg Glu Tyr Val Ser Gly Phe Gly Lys Ala Met Arg Met 
625                 630                 635                 640 


Pro Met Trp Ser Ser Tyr Thr Val Pro Gln Leu Gly Asp Thr Ser Pro 
                645                 650                 655     


Leu Pro Pro Thr Val Pro Asp Cys Leu Arg Ala Asp Val Arg Val Pro 
            660                 665                 670         


Pro Ser Glu Ser Gln Lys Cys Ser Phe Tyr Leu Ala Asp Lys Asn Ile 
        675                 680                 685             


Thr His Gly Phe Leu Tyr Pro Pro Ala Ser Asn Arg Thr Ser Asp Ser 
    690                 695                 700                 


Gln Tyr Asp Ala Leu Ile Thr Ser Asn Leu Val Pro Met Tyr Glu Glu 
705                 710                 715                 720 


Phe Arg Lys Met Trp Asp Tyr Phe His Ser Val Leu Leu Ile Lys His 
                725                 730                 735     


Ala Thr Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Ile Phe Asp 
            740                 745                 750         


Tyr Asn Tyr Asp Gly His Phe Asp Ala Pro Asp Glu Ile Thr Lys His 
        755                 760                 765             


Leu Ala Asn Thr Asp Val Pro Ile Pro Thr His Tyr Phe Val Val Leu 
    770                 775                 780                 


Thr Ser Cys Lys Asn Lys Ser His Thr Pro Glu Asn Cys Pro Gly Trp 
785                 790                 795                 800 


Leu Asp Val Leu Pro Phe Ile Ile Pro His Arg Pro Thr Asn Val Glu 
                805                 810                 815     


Ser Cys Pro Glu Gly Lys Pro Glu Ala Leu Trp Val Glu Glu Arg Phe 
            820                 825                 830         


Thr Ala His Ile Ala Arg Val Arg Asp Val Glu Leu Leu Thr Gly Leu 
        835                 840                 845             


Asp Phe Tyr Gln Asp Lys Val Gln Pro Val Ser Glu Ile Leu Gln Leu 
    850                 855                 860                 


Lys Thr Tyr Leu Pro Thr Phe Glu Thr Thr Ile 
865                 870                 875 


<210>  3200
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  3200

Met Ala Ser Leu Gly His Ile Leu Val Phe Cys Val Gly Leu Leu Thr 
1               5                   10                  15      


Met Ala Lys Ala Glu Ser Pro Lys Glu His Asp Pro Phe Thr Tyr Asp 
            20                  25                  30          


Tyr Gln Ser Leu Gln Ile Gly Gly Leu Val Ile Ala Gly Ile Leu Phe 
        35                  40                  45              


Ile Leu Gly Ile Leu Ile Val Leu Ser Arg Arg Cys Arg Cys Lys Phe 
    50                  55                  60                  


Asn Gln Gln Gln Arg Thr Gly Glu Pro Asp Glu Glu Glu Gly Thr Phe 
65                  70                  75                  80  


Arg Ser Ser Ile Arg Arg Leu Ser Thr Arg Arg Arg 
                85                  90          


<210>  3201
<211>  496
<212>  PRT
<213>  Homo sapiens

<400>  3201

Met Gly Arg Arg Ala Leu Leu Leu Leu Leu Leu Ser Phe Leu Ala Pro 
1               5                   10                  15      


Trp Ala Thr Ile Ala Leu Arg Pro Ala Leu Arg Ala Leu Gly Ser Leu 
            20                  25                  30          


His Leu Pro Thr Asn Pro Thr Ser Leu Pro Ala Val Ala Lys Asn Tyr 
        35                  40                  45              


Ser Val Leu Tyr Phe Gln Gln Lys Val Asp His Phe Gly Phe Asn Thr 
    50                  55                  60                  


Val Lys Thr Phe Asn Gln Arg Tyr Leu Val Ala Asp Lys Tyr Trp Lys 
65                  70                  75                  80  


Lys Asn Gly Gly Ser Ile Leu Phe Tyr Thr Gly Asn Glu Gly Asp Ile 
                85                  90                  95      


Ile Trp Phe Cys Asn Asn Thr Gly Phe Met Trp Asp Val Ala Glu Glu 
            100                 105                 110         


Leu Lys Ala Met Leu Val Phe Ala Glu His Arg Tyr Tyr Gly Glu Ser 
        115                 120                 125             


Leu Pro Phe Gly Asp Asn Ser Phe Lys Asp Ser Arg His Leu Asn Phe 
    130                 135                 140                 


Leu Thr Ser Glu Gln Ala Leu Ala Asp Phe Ala Glu Leu Ile Lys His 
145                 150                 155                 160 


Leu Lys Arg Thr Ile Pro Gly Ala Glu Asn Gln Pro Val Ile Ala Ile 
                165                 170                 175     


Gly Gly Ser Tyr Gly Gly Met Leu Ala Ala Trp Phe Arg Met Lys Tyr 
            180                 185                 190         


Pro His Met Val Val Gly Ala Leu Ala Ala Ser Ala Pro Ile Trp Gln 
        195                 200                 205             


Phe Glu Asp Leu Val Pro Cys Gly Val Phe Met Lys Ile Val Thr Thr 
    210                 215                 220                 


Asp Phe Arg Lys Ser Gly Pro His Cys Ser Glu Ser Ile His Arg Ser 
225                 230                 235                 240 


Trp Asp Ala Ile Asn Arg Leu Ser Asn Thr Gly Ser Gly Leu Gln Trp 
                245                 250                 255     


Leu Thr Gly Ala Leu His Leu Cys Ser Pro Leu Thr Ser Gln Asp Ile 
            260                 265                 270         


Gln His Leu Lys Asp Trp Ile Ser Glu Thr Trp Val Asn Leu Ala Met 
        275                 280                 285             


Val Asp Tyr Pro Tyr Ala Ser Asn Phe Leu Gln Pro Leu Pro Ala Trp 
    290                 295                 300                 


Pro Ile Lys Val Val Cys Gln Tyr Leu Lys Asn Pro Asn Val Ser Asp 
305                 310                 315                 320 


Ser Leu Leu Leu Gln Asn Ile Phe Gln Ala Leu Asn Val Tyr Tyr Asn 
                325                 330                 335     


Tyr Ser Gly Gln Val Lys Cys Leu Asn Ile Ser Glu Thr Ala Thr Ser 
            340                 345                 350         


Ser Leu Gly Thr Leu Gly Trp Ser Tyr Gln Ala Cys Thr Glu Val Val 
        355                 360                 365             


Met Pro Phe Cys Thr Asn Gly Val Asp Asp Met Phe Glu Pro His Ser 
    370                 375                 380                 


Trp Asn Leu Lys Glu Leu Ser Asp Asp Cys Phe Gln Gln Trp Gly Val 
385                 390                 395                 400 


Arg Pro Arg Pro Ser Trp Ile Thr Thr Met Tyr Gly Gly Lys Asn Ile 
                405                 410                 415     


Ser Ser His Thr Asn Ile Val Phe Ser Asn Gly Glu Leu Asp Pro Trp 
            420                 425                 430         


Ser Gly Gly Gly Val Thr Lys Asp Ile Thr Asp Thr Leu Val Ala Val 
        435                 440                 445             


Thr Ile Ser Glu Gly Ala His His Leu Asp Leu Arg Thr Lys Asn Ala 
    450                 455                 460                 


Leu Asp Pro Met Ser Val Leu Leu Ala Arg Ser Leu Glu Val Arg His 
465                 470                 475                 480 


Met Lys Asn Trp Ile Arg Asp Phe Tyr Asp Ser Ala Gly Lys Gln His 
                485                 490                 495     


<210>  3202
<211>  606
<212>  PRT
<213>  Homo sapiens

<400>  3202

Met Ala Val Ala Gly Pro Ala Pro Gly Ala Gly Ala Arg Pro Arg Leu 
1               5                   10                  15      


Asp Leu Gln Phe Leu Gln Arg Phe Leu Gln Ile Leu Lys Val Leu Phe 
            20                  25                  30          


Pro Ser Trp Ser Ser Gln Asn Ala Leu Met Phe Leu Thr Leu Leu Cys 
        35                  40                  45              


Leu Thr Leu Leu Glu Gln Phe Val Ile Tyr Gln Val Gly Leu Ile Pro 
    50                  55                  60                  


Ser Gln Tyr Tyr Gly Val Leu Gly Asn Lys Asp Leu Glu Gly Phe Lys 
65                  70                  75                  80  


Thr Leu Thr Phe Leu Ala Val Met Leu Ile Val Leu Asn Ser Thr Leu 
                85                  90                  95      


Lys Ser Phe Asp Gln Phe Thr Cys Asn Leu Leu Tyr Val Ser Trp Arg 
            100                 105                 110         


Lys Asp Leu Thr Glu His Leu His Arg Leu Tyr Phe Arg Gly Arg Ala 
        115                 120                 125             


Tyr Tyr Thr Leu Asn Val Leu Arg Asp Asp Ile Asp Asn Pro Asp Gln 
    130                 135                 140                 


Arg Ile Ser Gln Asp Val Glu Arg Phe Cys Arg Gln Leu Ser Ser Met 
145                 150                 155                 160 


Ala Ser Lys Leu Ile Ile Ser Pro Phe Thr Leu Val Tyr Tyr Thr Tyr 
                165                 170                 175     


Gln Cys Phe Gln Ser Thr Gly Trp Leu Gly Pro Val Ser Ile Phe Gly 
            180                 185                 190         


Tyr Phe Ile Leu Gly Thr Val Val Asn Lys Thr Leu Met Gly Pro Ile 
        195                 200                 205             


Val Met Lys Leu Val His Gln Glu Lys Leu Glu Gly Asp Phe Arg Phe 
    210                 215                 220                 


Lys His Met Gln Ile Arg Val Asn Ala Glu Pro Ala Ala Phe Tyr Arg 
225                 230                 235                 240 


Ala Gly His Val Glu His Met Arg Thr Asp Arg Arg Leu Gln Arg Leu 
                245                 250                 255     


Leu Gln Thr Gln Arg Glu Leu Met Ser Lys Glu Leu Trp Leu Tyr Ile 
            260                 265                 270         


Gly Ile Asn Thr Phe Asp Tyr Leu Gly Ser Ile Leu Ser Tyr Val Val 
        275                 280                 285             


Ile Ala Ile Pro Ile Phe Ser Gly Val Tyr Gly Asp Leu Ser Pro Ala 
    290                 295                 300                 


Glu Leu Ser Thr Leu Val Ser Lys Asn Ala Phe Val Cys Ile Tyr Leu 
305                 310                 315                 320 


Ile Ser Cys Phe Thr Gln Leu Ile Asp Leu Ser Thr Thr Leu Ser Asp 
                325                 330                 335     


Val Ala Gly Tyr Thr His Arg Ile Gly Gln Leu Arg Glu Thr Leu Leu 
            340                 345                 350         


Asp Met Ser Leu Lys Ser Gln Asp Cys Glu Ile Leu Gly Glu Ser Glu 
        355                 360                 365             


Trp Gly Leu Asp Thr Pro Pro Gly Trp Pro Ala Ala Glu Pro Ala Asp 
    370                 375                 380                 


Thr Ala Phe Leu Leu Glu Arg Val Ser Ile Ser Ala Pro Ser Ser Asp 
385                 390                 395                 400 


Lys Pro Leu Ile Lys Asp Leu Ser Leu Lys Ile Ser Glu Gly Gln Ser 
                405                 410                 415     


Leu Leu Ile Thr Gly Asn Thr Gly Thr Gly Lys Thr Ser Leu Leu Arg 
            420                 425                 430         


Val Leu Gly Gly Leu Trp Thr Ser Thr Arg Gly Ser Val Gln Met Leu 
        435                 440                 445             


Thr Asp Phe Gly Pro His Gly Val Leu Phe Leu Pro Gln Lys Pro Phe 
    450                 455                 460                 


Phe Thr Asp Gly Thr Leu Arg Glu Gln Val Ile Tyr Pro Leu Lys Glu 
465                 470                 475                 480 


Val Tyr Pro Asp Ser Gly Ser Ala Asp Asp Glu Arg Ile Leu Arg Phe 
                485                 490                 495     


Leu Glu Leu Ala Gly Leu Ser Asn Leu Val Ala Arg Thr Glu Gly Leu 
            500                 505                 510         


Asp Gln Gln Val Asp Trp Asn Trp Tyr Asp Val Leu Ser Pro Gly Glu 
        515                 520                 525             


Met Gln Arg Leu Ser Phe Ala Arg Leu Phe Tyr Leu Gln Pro Lys Tyr 
    530                 535                 540                 


Ala Val Leu Asp Glu Ala Thr Ser Ala Leu Thr Glu Glu Val Glu Ser 
545                 550                 555                 560 


Glu Leu Tyr Arg Ile Gly Gln Gln Leu Gly Met Thr Phe Ile Ser Val 
                565                 570                 575     


Gly His Arg Gln Ser Leu Glu Lys Phe His Ser Leu Val Leu Lys Leu 
            580                 585                 590         


Cys Gly Gly Gly Arg Trp Glu Leu Met Arg Ile Lys Val Glu 
        595                 600                 605     


<210>  3203
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  3203

Met Pro Ala His Leu Leu Gln Asp Asp Ile Ser Ser Ser Tyr Thr Thr 
1               5                   10                  15      


Thr Thr Thr Ile Thr Ala Pro Pro Ser Arg Val Leu Gln Asn Gly Gly 
            20                  25                  30          


Asp Lys Leu Glu Thr Met Pro Leu Tyr Leu Glu Asp Asp Ile Arg Pro 
        35                  40                  45              


Asp Ile Lys Asp Asp Ile Tyr Asp Pro Thr Tyr Lys Asp Lys Glu Gly 
    50                  55                  60                  


Pro Ser Pro Lys Val Glu Tyr Val Trp Arg Asn Ile Ile Leu Met Ser 
65                  70                  75                  80  


Leu Leu His Leu Gly Ala Leu Tyr Gly Ile Thr Leu Ile Pro Thr Cys 
                85                  90                  95      


Lys Phe Tyr Thr Trp Leu Trp Gly Val Phe Tyr Tyr Phe Val Ser Ala 
            100                 105                 110         


Leu Gly Ile Thr Ala Gly Ala His Arg Leu Trp Ser His Arg Ser Tyr 
        115                 120                 125             


Lys Ala Arg Leu Pro Leu Arg Leu Phe Leu Ile Ile Ala Asn Thr Met 
    130                 135                 140                 


Ala Phe Gln Asn Asp Val Tyr Glu Trp Ala Arg Asp His Arg Ala His 
145                 150                 155                 160 


His Lys Phe Ser Glu Thr His Ala Asp Pro His Asn Ser Arg Arg Gly 
                165                 170                 175     


Phe Phe Phe Ser His Val Gly Trp Leu Leu Val Arg Lys His Pro Ala 
            180                 185                 190         


Val Lys Glu Lys Gly Ser Thr Leu Asp Leu Ser Asp Leu Glu Ala Glu 
        195                 200                 205             


Lys Leu Val Met Phe Gln Arg Arg Tyr Tyr Lys Pro Gly Leu Leu Met 
    210                 215                 220                 


Met Cys Phe Ile Leu Pro Thr Leu Val Pro Trp Tyr Phe Trp Gly Glu 
225                 230                 235                 240 


Thr Phe Gln Asn Ser Val Phe Val Ala Thr Phe Leu Arg Tyr Ala Val 
                245                 250                 255     


Val Leu Asn Ala Thr Trp Leu Val Asn Ser Ala Ala His Leu Phe Gly 
            260                 265                 270         


Tyr Arg Pro Tyr Asp Lys Asn Ile Ser Pro Arg Glu Asn Ile Leu Val 
        275                 280                 285             


Ser Leu Gly Ala Val Gly Glu Gly Phe His Asn Tyr His His Ser Phe 
    290                 295                 300                 


Pro Tyr Asp Tyr Ser Ala Ser Glu Tyr Arg Trp His Ile Asn Phe Thr 
305                 310                 315                 320 


Thr Phe Phe Ile Asp Cys Met Ala Ala Leu Gly Leu Ala Tyr Asp Arg 
                325                 330                 335     


Lys Lys Val Ser Lys Ala Ala Ile Leu Ala Arg Ile Lys Arg Thr Gly 
            340                 345                 350         


Asp Gly Asn Tyr Lys Ser Gly 
        355                 


<210>  3204
<211>  794
<212>  PRT
<213>  Homo sapiens

<400>  3204

Met Arg Val Arg Ile Gly Leu Thr Leu Leu Leu Cys Ala Val Leu Leu 
1               5                   10                  15      


Ser Leu Ala Ser Ala Ser Ser Asp Glu Glu Gly Ser Gln Asp Glu Ser 
            20                  25                  30          


Leu Asp Ser Lys Thr Thr Leu Thr Ser Asp Glu Ser Val Lys Asp His 
        35                  40                  45              


Thr Thr Ala Gly Arg Val Val Ala Gly Gln Ile Phe Leu Asp Ser Glu 
    50                  55                  60                  


Glu Ser Glu Leu Glu Ser Ser Ile Gln Glu Glu Glu Asp Ser Leu Lys 
65                  70                  75                  80  


Ser Gln Glu Gly Glu Ser Val Thr Glu Asp Ile Ser Phe Leu Glu Ser 
                85                  90                  95      


Pro Asn Pro Glu Asn Lys Asp Tyr Glu Glu Pro Lys Lys Val Arg Lys 
            100                 105                 110         


Pro Ala Leu Thr Ala Ile Glu Gly Thr Ala His Gly Glu Pro Cys His 
        115                 120                 125             


Phe Pro Phe Leu Phe Leu Asp Lys Glu Tyr Asp Glu Cys Thr Ser Asp 
    130                 135                 140                 


Gly Arg Glu Asp Gly Arg Leu Trp Cys Ala Thr Thr Tyr Asp Tyr Lys 
145                 150                 155                 160 


Ala Asp Glu Lys Trp Gly Phe Cys Glu Thr Glu Glu Glu Ala Ala Lys 
                165                 170                 175     


Arg Arg Gln Met Gln Glu Ala Glu Met Met Tyr Gln Thr Gly Met Lys 
            180                 185                 190         


Ile Leu Asn Gly Ser Asn Lys Lys Ser Gln Lys Arg Glu Ala Tyr Arg 
        195                 200                 205             


Tyr Leu Gln Lys Ala Ala Ser Met Asn His Thr Lys Ala Leu Glu Arg 
    210                 215                 220                 


Val Ser Tyr Ala Leu Leu Phe Gly Asp Tyr Leu Pro Gln Asn Ile Gln 
225                 230                 235                 240 


Ala Ala Arg Glu Met Phe Glu Lys Leu Thr Glu Glu Gly Ser Pro Lys 
                245                 250                 255     


Gly Gln Thr Ala Leu Gly Phe Leu Tyr Ala Ser Gly Leu Gly Val Asn 
            260                 265                 270         


Ser Ser Gln Ala Lys Ala Leu Val Tyr Tyr Thr Phe Gly Ala Leu Gly 
        275                 280                 285             


Gly Asn Leu Ile Ala His Met Val Leu Gly Tyr Arg Tyr Trp Ala Gly 
    290                 295                 300                 


Ile Gly Val Leu Gln Ser Cys Glu Ser Ala Leu Thr His Tyr Arg Leu 
305                 310                 315                 320 


Val Ala Asn His Val Ala Ser Asp Ile Ser Leu Thr Gly Gly Ser Val 
                325                 330                 335     


Val Gln Arg Ile Arg Leu Pro Asp Glu Val Glu Asn Pro Gly Met Asn 
            340                 345                 350         


Ser Gly Met Leu Glu Glu Asp Leu Ile Gln Tyr Tyr Gln Phe Leu Ala 
        355                 360                 365             


Glu Lys Gly Asp Val Gln Ala Gln Val Gly Leu Gly Gln Leu His Leu 
    370                 375                 380                 


His Gly Gly Arg Gly Val Glu Gln Asn His Gln Arg Ala Phe Asp Tyr 
385                 390                 395                 400 


Phe Asn Leu Ala Ala Asn Ala Gly Asn Ser His Ala Met Ala Phe Leu 
                405                 410                 415     


Gly Lys Met Tyr Ser Glu Gly Ser Asp Ile Val Pro Gln Ser Asn Glu 
            420                 425                 430         


Thr Ala Leu His Tyr Phe Lys Lys Ala Ala Asp Met Gly Asn Pro Val 
        435                 440                 445             


Gly Gln Ser Gly Leu Gly Met Ala Tyr Leu Tyr Gly Arg Gly Val Gln 
    450                 455                 460                 


Val Asn Tyr Asp Leu Ala Leu Lys Tyr Phe Gln Lys Ala Ala Glu Gln 
465                 470                 475                 480 


Gly Trp Val Asp Gly Gln Leu Gln Leu Gly Ser Met Tyr Tyr Asn Gly 
                485                 490                 495     


Ile Gly Val Lys Arg Asp Tyr Lys Gln Ala Leu Lys Tyr Phe Asn Leu 
            500                 505                 510         


Ala Ser Gln Gly Gly His Ile Leu Ala Phe Tyr Asn Leu Ala Gln Met 
        515                 520                 525             


His Ala Ser Gly Thr Gly Val Met Arg Ser Cys His Thr Ala Val Glu 
    530                 535                 540                 


Leu Phe Lys Asn Val Cys Glu Arg Gly Arg Trp Ser Glu Arg Leu Met 
545                 550                 555                 560 


Thr Ala Tyr Asn Ser Tyr Lys Asp Gly Asp Tyr Asn Ala Ala Val Ile 
                565                 570                 575     


Gln Tyr Leu Leu Leu Ala Glu Gln Gly Tyr Glu Val Ala Gln Ser Asn 
            580                 585                 590         


Ala Ala Phe Ile Leu Asp Gln Arg Glu Ala Ser Ile Val Gly Glu Asn 
        595                 600                 605             


Glu Thr Tyr Pro Arg Ala Leu Leu His Trp Asn Arg Ala Ala Ser Gln 
    610                 615                 620                 


Gly Tyr Thr Val Ala Arg Ile Lys Leu Gly Asp Tyr His Phe Tyr Gly 
625                 630                 635                 640 


Phe Gly Thr Asp Val Asp Tyr Glu Thr Ala Phe Ile His Tyr Arg Leu 
                645                 650                 655     


Ala Ser Glu Gln Gln His Ser Ala Gln Ala Met Phe Asn Leu Gly Tyr 
            660                 665                 670         


Met His Glu Lys Gly Leu Gly Ile Lys Gln Asp Ile His Leu Ala Lys 
        675                 680                 685             


Arg Phe Tyr Asp Met Ala Ala Glu Ala Ser Pro Asp Ala Gln Val Pro 
    690                 695                 700                 


Val Phe Leu Ala Leu Cys Lys Leu Gly Val Val Tyr Phe Leu Gln Tyr 
705                 710                 715                 720 


Ile Arg Glu Thr Asn Ile Arg Asp Met Phe Thr Gln Leu Asp Met Asp 
                725                 730                 735     


Gln Leu Leu Gly Pro Glu Trp Asp Leu Tyr Leu Met Thr Ile Ile Ala 
            740                 745                 750         


Leu Leu Leu Gly Thr Val Ile Ala Tyr Arg Gln Arg Gln His Gln Asp 
        755                 760                 765             


Met Pro Ala Pro Arg Pro Pro Gly Pro Arg Pro Ala Pro Pro Gln Gln 
    770                 775                 780                 


Glu Gly Pro Pro Glu Gln Gln Pro Pro Gln 
785                 790                 


<210>  3205
<211>  1232
<212>  PRT
<213>  Homo sapiens

<400>  3205

Met Ala Asn Gly Val Ile Pro Pro Pro Gly Gly Ala Ser Pro Leu Pro 
1               5                   10                  15      


Gln Val Arg Val Pro Leu Glu Glu Pro Pro Leu Ser Pro Asp Val Glu 
            20                  25                  30          


Glu Glu Asp Asp Asp Leu Gly Lys Thr Leu Ala Val Ser Arg Phe Gly 
        35                  40                  45              


Asp Leu Ile Ser Lys Pro Pro Ala Trp Asp Pro Glu Lys Pro Ser Arg 
    50                  55                  60                  


Ser Tyr Ser Glu Arg Asp Phe Glu Phe His Arg His Thr Ser His His 
65                  70                  75                  80  


Thr His His Pro Leu Ser Ala Arg Leu Pro Pro Pro His Lys Leu Arg 
                85                  90                  95      


Arg Leu Pro Pro Thr Ser Ala Arg His Thr Arg Arg Lys Arg Lys Lys 
            100                 105                 110         


Glu Lys Thr Ser Ala Pro Pro Ser Glu Gly Thr Pro Pro Ile Gln Glu 
        115                 120                 125             


Glu Gly Gly Ala Gly Val Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu 
    130                 135                 140                 


Glu Gly Glu Ser Glu Ala Glu Pro Val Glu Pro Pro Pro Ser Gly Thr 
145                 150                 155                 160 


Pro Gln Lys Ala Lys Phe Ser Ile Gly Ser Asp Glu Asp Asp Ser Pro 
                165                 170                 175     


Gly Leu Pro Gly Arg Ala Ala Val Thr Lys Pro Leu Pro Ser Val Gly 
            180                 185                 190         


Pro His Thr Asp Lys Ser Pro Gln His Ser Ser Ser Ser Pro Ser Pro 
        195                 200                 205             


Arg Ala Arg Ala Ser Arg Leu Ala Gly Glu Lys Ser Arg Pro Trp Ser 
    210                 215                 220                 


Pro Ser Ala Ser Tyr Asp Leu Arg Glu Arg Leu Cys Pro Gly Ser Ala 
225                 230                 235                 240 


Leu Gly Asn Pro Gly Gly Pro Glu Gln Gln Val Pro Thr Asp Glu Ala 
                245                 250                 255     


Glu Ala Gln Met Leu Gly Ser Ala Asp Leu Asp Asp Met Lys Ser His 
            260                 265                 270         


Arg Leu Glu Asp Asn Pro Gly Val Arg Arg His Leu Val Lys Lys Pro 
        275                 280                 285             


Ser Arg Thr Gln Gly Gly Arg Gly Ser Pro Ser Gly Leu Ala Pro Ile 
    290                 295                 300                 


Leu Arg Arg Lys Lys Lys Lys Lys Lys Leu Asp Arg Arg Pro His Glu 
305                 310                 315                 320 


Val Phe Val Glu Leu Asn Glu Leu Met Leu Asp Arg Ser Gln Glu Pro 
                325                 330                 335     


His Trp Arg Glu Thr Ala Arg Trp Ile Lys Phe Glu Glu Asp Val Glu 
            340                 345                 350         


Glu Glu Thr Glu Arg Trp Gly Lys Pro His Val Ala Ser Leu Ser Phe 
        355                 360                 365             


Arg Ser Leu Leu Glu Leu Arg Arg Thr Ile Ala His Gly Ala Ala Leu 
    370                 375                 380                 


Leu Asp Leu Glu Gln Thr Thr Leu Pro Gly Ile Ala His Leu Val Val 
385                 390                 395                 400 


Glu Thr Met Ile Val Ser Asp Gln Ile Arg Pro Glu Asp Arg Ala Ser 
                405                 410                 415     


Val Leu Arg Thr Leu Leu Leu Lys His Ser His Pro Asn Asp Asp Lys 
            420                 425                 430         


Asp Ser Gly Phe Phe Pro Arg Asn Pro Ser Ser Ser Ser Met Asn Ser 
        435                 440                 445             


Val Leu Gly Asn His His Pro Thr Pro Ser His Gly Pro Asp Gly Ala 
    450                 455                 460                 


Val Pro Thr Met Ala Asp Asp Leu Gly Glu Pro Ala Pro Leu Trp Pro 
465                 470                 475                 480 


His Asp Pro Asp Ala Lys Glu Lys Pro Leu His Met Pro Gly Gly Asp 
                485                 490                 495     


Gly His Arg Gly Lys Ser Leu Lys Leu Leu Glu Lys Ile Pro Glu Asp 
            500                 505                 510         


Ala Glu Ala Thr Val Val Leu Val Gly Cys Val Pro Phe Leu Glu Gln 
        515                 520                 525             


Pro Ala Ala Ala Phe Val Arg Leu Asn Glu Ala Val Leu Leu Glu Ser 
    530                 535                 540                 


Val Leu Glu Val Pro Val Pro Val Arg Phe Leu Phe Val Met Leu Gly 
545                 550                 555                 560 


Pro Ser His Thr Ser Thr Asp Tyr His Glu Leu Gly Arg Ser Ile Ala 
                565                 570                 575     


Thr Leu Met Ser Asp Lys Leu Phe His Glu Ala Ala Tyr Gln Ala Asp 
            580                 585                 590         


Asp Arg Gln Asp Leu Leu Ser Ala Ile Ser Glu Phe Leu Asp Gly Ser 
        595                 600                 605             


Ile Val Ile Pro Pro Ser Glu Val Glu Gly Arg Asp Leu Leu Arg Ser 
    610                 615                 620                 


Val Ala Ala Phe Gln Arg Glu Leu Leu Arg Lys Arg Arg Glu Arg Glu 
625                 630                 635                 640 


Gln Thr Lys Val Glu Met Thr Thr Arg Gly Gly Tyr Thr Ala Pro Gly 
                645                 650                 655     


Lys Glu Leu Ser Leu Glu Leu Gly Gly Ser Glu Ala Thr Pro Glu Asp 
            660                 665                 670         


Asp Pro Leu Leu Arg Thr Gly Ser Val Phe Gly Gly Leu Val Arg Asp 
        675                 680                 685             


Val Arg Arg Arg Tyr Pro His Tyr Pro Ser Asp Leu Arg Asp Ala Leu 
    690                 695                 700                 


His Ser Gln Cys Val Ala Ala Val Leu Phe Ile Tyr Phe Ala Ala Leu 
705                 710                 715                 720 


Ser Pro Ala Ile Thr Phe Gly Gly Leu Leu Gly Glu Lys Thr Glu Gly 
                725                 730                 735     


Leu Met Gly Val Ser Glu Leu Ile Val Ser Thr Ala Val Leu Gly Val 
            740                 745                 750         


Leu Phe Ser Leu Leu Gly Ala Gln Pro Leu Leu Val Val Gly Phe Ser 
        755                 760                 765             


Gly Pro Leu Leu Val Phe Glu Glu Ala Phe Phe Lys Phe Cys Arg Ala 
    770                 775                 780                 


Gln Asp Leu Glu Tyr Leu Thr Gly Arg Val Trp Val Gly Leu Trp Leu 
785                 790                 795                 800 


Val Val Phe Val Leu Ala Leu Val Ala Ala Glu Gly Ser Phe Leu Val 
                805                 810                 815     


Arg Tyr Ile Ser Pro Phe Thr Gln Glu Ile Phe Ala Phe Leu Ile Ser 
            820                 825                 830         


Leu Ile Phe Ile Tyr Glu Thr Phe Tyr Lys Leu Tyr Lys Val Phe Thr 
        835                 840                 845             


Glu His Pro Leu Leu Pro Phe Tyr Pro Pro Glu Gly Ala Leu Glu Gly 
    850                 855                 860                 


Ser Leu Asp Ala Gly Leu Glu Pro Asn Gly Ser Ala Leu Pro Pro Thr 
865                 870                 875                 880 


Glu Gly Pro Pro Ser Pro Arg Asn Gln Pro Asn Thr Ala Leu Leu Ser 
                885                 890                 895     


Leu Ile Leu Met Leu Gly Thr Phe Phe Ile Ala Phe Phe Leu Arg Lys 
            900                 905                 910         


Phe Arg Asn Ser Arg Phe Leu Gly Gly Lys Ala Arg Arg Ile Ile Gly 
        915                 920                 925             


Asp Phe Gly Ile Pro Ile Ser Ile Leu Val Met Val Leu Val Asp Tyr 
    930                 935                 940                 


Ser Ile Thr Asp Thr Tyr Thr Gln Lys Leu Thr Val Pro Thr Gly Leu 
945                 950                 955                 960 


Ser Val Thr Ser Pro Asp Lys Arg Ser Trp Phe Ile Pro Pro Leu Gly 
                965                 970                 975     


Ser Ala Arg Pro Phe Pro Pro Trp Met Met Val Ala Ala Ala Val Pro 
            980                 985                 990         


Ala Leu Leu Val Leu Ile Leu Ile  Phe Met Glu Thr Gln  Ile Thr Ala 
        995                 1000                 1005             


Leu Ile  Val Ser Gln Lys Ala  Arg Arg Leu Leu Lys  Gly Ser Gly 
    1010                 1015                 1020             


Phe His  Leu Asp Leu Leu Leu  Ile Gly Ser Leu Gly  Gly Leu Cys 
    1025                 1030                 1035             


Gly Leu  Phe Gly Leu Pro Trp  Leu Thr Ala Ala Thr  Val Arg Ser 
    1040                 1045                 1050             


Val Thr  His Val Asn Ala Leu  Thr Val Met Arg Thr  Ala Ile Ala 
    1055                 1060                 1065             


Pro Gly  Asp Lys Pro Gln Ile  Gln Glu Val Arg Glu  Gln Arg Val 
    1070                 1075                 1080             


Thr Gly  Val Leu Ile Ala Ser  Leu Val Gly Leu Ser  Ile Val Met 
    1085                 1090                 1095             


Gly Ala  Val Leu Arg Arg Ile  Pro Leu Ala Val Leu  Phe Gly Ile 
    1100                 1105                 1110             


Phe Leu  Tyr Met Gly Val Thr  Ser Leu Ser Gly Ile  Gln Leu Ser 
    1115                 1120                 1125             


Gln Arg  Leu Leu Leu Ile Leu  Met Pro Ala Lys His  His Pro Glu 
    1130                 1135                 1140             


Gln Pro  Tyr Val Thr Lys Val  Lys Thr Trp Arg Met  His Leu Phe 
    1145                 1150                 1155             


Thr Cys  Ile Gln Leu Gly Cys  Ile Ala Leu Leu Trp  Val Val Lys 
    1160                 1165                 1170             


Ser Thr  Ala Ala Ser Leu Ala  Phe Pro Phe Leu Leu  Leu Leu Thr 
    1175                 1180                 1185             


Val Pro  Leu Arg His Cys Leu  Leu Pro Arg Leu Phe  Gln Asp Arg 
    1190                 1195                 1200             


Glu Leu  Gln Ala Leu Asp Ser  Glu Asp Ala Glu Pro  Asn Phe Asp 
    1205                 1210                 1215             


Glu Asp  Gly Gln Asp Glu Tyr  Asn Glu Leu His Met  Pro Val 
    1220                 1225                 1230         


<210>  3206
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  3206

Met Ser Ser His Gly Asn Ser Leu Phe Leu Arg Glu Ser Gly Gln Arg 
1               5                   10                  15      


Leu Gly Arg Val Gly Trp Leu Gln Arg Leu Gln Glu Ser Leu Gln Gln 
            20                  25                  30          


Arg Ala Leu Arg Thr Arg Leu Arg Leu Gln Thr Met Thr Leu Glu His 
        35                  40                  45              


Val Leu Arg Phe Leu Arg Arg Asn Ala Phe Ile Leu Leu Thr Val Ser 
    50                  55                  60                  


Ala Val Val Ile Gly Val Ser Leu Ala Phe Ala Leu Arg Pro Tyr Gln 
65                  70                  75                  80  


Leu Thr Tyr Arg Gln Ile Lys Tyr Phe Ser Phe Pro Gly Glu Leu Leu 
                85                  90                  95      


Met Arg Met Leu Gln Met Leu Val Leu Pro Leu Ile Val Ser Ser Leu 
            100                 105                 110         


Val Thr Gly Met Ala Ser Leu Asp Asn Lys Ala Thr Gly Arg Met Gly 
        115                 120                 125             


Met Arg Ala Ala Val Tyr Tyr Met Val Thr Thr Ile Ile Ala Val Phe 
    130                 135                 140                 


Ile Gly Ile Leu Met Val Thr Ile Ile His Pro Gly Lys Gly Ser Lys 
145                 150                 155                 160 


Glu Gly Leu His Arg Glu Gly Arg Ile Glu Thr Ile Pro Thr Ala Asp 
                165                 170                 175     


Ala Phe Met Asp Leu Ile Arg Asn Met Phe Pro Pro Asn Leu Val Glu 
            180                 185                 190         


Ala Cys Phe Lys Gln Phe Lys Thr Gln Tyr Ser Thr Arg Val Val Thr 
        195                 200                 205             


Arg Thr Met Val Arg Thr Glu Asn Gly Ser Glu Pro Gly Ala Ser Met 
    210                 215                 220                 


Pro Pro Pro Phe Ser Val Glu Asn Gly Thr Ser Phe Leu Glu Asn Val 
225                 230                 235                 240 


Thr Arg Ala Leu Gly Thr Leu Gln Glu Met Leu Ser Phe Glu Glu Thr 
                245                 250                 255     


Val Pro Val Pro Gly Ser Ala Asn Gly Ile Asn Ala Leu Gly Leu Val 
            260                 265                 270         


Val Phe Ser Val Ala Phe Gly Leu Val Ile Gly Gly Met Lys His Lys 
        275                 280                 285             


Gly Arg Val Leu Arg Asp Phe Phe Asp Ser Leu Asn Glu Ala Ile Met 
    290                 295                 300                 


Arg Leu Val Gly Ile Ile Ile Trp Tyr Ala Pro Val Gly Ile Leu Phe 
305                 310                 315                 320 


Leu Ile Ala Gly Lys Ile Leu Glu Met Glu Asp Met Ala Val Leu Gly 
                325                 330                 335     


Gly Gln Leu Gly Met Tyr Thr Leu Thr Val Ile Val Gly Leu Phe Leu 
            340                 345                 350         


His Ala Gly Ile Val Leu Pro Leu Ile Tyr Phe Leu Val Thr His Arg 
        355                 360                 365             


Asn Pro Phe Pro Phe Ile Gly Gly Met Leu Gln Ala Leu Ile Thr Ala 
    370                 375                 380                 


Met Gly Thr Ser Ser Ser Ser Ala Thr Leu Pro Ile Thr Phe Arg Cys 
385                 390                 395                 400 


Leu Glu Glu Gly Leu Gly Val Asp Arg Arg Ile Thr Arg Phe Val Leu 
                405                 410                 415     


Pro Val Gly Ala Thr Val Asn Met Asp Gly Thr Ala Leu Tyr Glu Ala 
            420                 425                 430         


Leu Ala Ala Ile Phe Ile Ala Gln Val Asn Asn Tyr Glu Leu Asn Leu 
        435                 440                 445             


Gly Gln Ile Thr Thr Ile Ser Ile Thr Ala Thr Ala Ala Ser Val Gly 
    450                 455                 460                 


Ala Ala Gly Ile Pro Gln Ala Gly Leu Val Thr Met Val Ile Val Leu 
465                 470                 475                 480 


Thr Ser Val Gly Leu Pro Thr Glu Asp Ile Thr Leu Ile Ile Ala Val 
                485                 490                 495     


Asp Trp Phe Leu Asp Arg Leu Arg Thr Met Thr Asn Val Leu Gly Asp 
            500                 505                 510         


Ser Ile Gly Ala Ala Val Ile Glu His Leu Ser Gln Arg Glu Leu Glu 
        515                 520                 525             


Leu Gln Glu Ala Glu Leu Thr Leu Pro Ser Leu Gly Lys Pro Tyr Lys 
    530                 535                 540                 


Ser Leu Met Ala Gln Glu Lys Gly Ala Ser Arg Gly Arg Gly Gly Asn 
545                 550                 555                 560 


Glu Ser Ala Met 
                


<210>  3207
<211>  1085
<212>  PRT
<213>  Homo sapiens

<400>  3207

Met Pro His Phe Thr Val Val Pro Val Asp Gly Pro Arg Arg Gly Asp 
1               5                   10                  15      


Tyr Asp Asn Leu Glu Gly Leu Ser Trp Val Asp Tyr Gly Glu Arg Ala 
            20                  25                  30          


Glu Leu Asp Asp Ser Asp Gly His Gly Asn His Arg Glu Ser Ser Pro 
        35                  40                  45              


Phe Leu Ser Pro Leu Glu Ala Ser Arg Gly Ile Asp Tyr Tyr Asp Arg 
    50                  55                  60                  


Asn Leu Ala Leu Phe Glu Glu Glu Leu Asp Ile Arg Pro Lys Val Ser 
65                  70                  75                  80  


Ser Leu Leu Gly Lys Leu Val Ser Tyr Thr Asn Leu Thr Gln Gly Ala 
                85                  90                  95      


Lys Glu His Glu Glu Ala Glu Ser Gly Glu Gly Thr Arg Arg Arg Ala 
            100                 105                 110         


Ala Glu Ala Pro Ser Met Gly Thr Leu Met Gly Val Tyr Leu Pro Cys 
        115                 120                 125             


Leu Gln Asn Ile Phe Gly Val Ile Leu Phe Leu Arg Leu Thr Trp Met 
    130                 135                 140                 


Val Gly Thr Ala Gly Val Leu Gln Ala Leu Leu Ile Val Leu Ile Cys 
145                 150                 155                 160 


Cys Cys Cys Thr Leu Leu Thr Ala Ile Ser Met Ser Ala Ile Ala Thr 
                165                 170                 175     


Asn Gly Val Val Pro Ala Gly Gly Ser Tyr Phe Met Ile Ser Arg Ser 
            180                 185                 190         


Leu Gly Pro Glu Phe Gly Gly Ala Val Gly Leu Cys Phe Tyr Leu Gly 
        195                 200                 205             


Thr Thr Phe Ala Ala Ala Met Tyr Ile Leu Gly Ala Ile Glu Ile Leu 
    210                 215                 220                 


Leu Thr Tyr Ile Ala Pro Pro Ala Ala Ile Phe Tyr Pro Ser Gly Ala 
225                 230                 235                 240 


His Asp Thr Ser Asn Ala Thr Leu Asn Asn Met Arg Val Tyr Gly Thr 
                245                 250                 255     


Ile Phe Leu Thr Phe Met Thr Leu Val Val Phe Val Gly Val Lys Tyr 
            260                 265                 270         


Val Asn Lys Phe Ala Ser Leu Phe Leu Ala Cys Val Ile Ile Ser Ile 
        275                 280                 285             


Leu Ser Ile Tyr Ala Gly Gly Ile Lys Ser Ile Phe Asp Pro Pro Val 
    290                 295                 300                 


Phe Pro Val Cys Met Leu Gly Asn Arg Thr Leu Ser Arg Asp Gln Phe 
305                 310                 315                 320 


Asp Ile Cys Ala Lys Thr Ala Val Val Asp Asn Glu Thr Val Ala Thr 
                325                 330                 335     


Gln Leu Trp Ser Phe Phe Cys His Ser Pro Asn Leu Thr Thr Asp Ser 
            340                 345                 350         


Cys Asp Pro Tyr Phe Met Leu Asn Asn Val Thr Glu Ile Pro Gly Ile 
        355                 360                 365             


Pro Gly Ala Ala Ala Gly Val Leu Gln Glu Asn Leu Trp Ser Ala Tyr 
    370                 375                 380                 


Leu Glu Lys Gly Asp Ile Val Glu Lys His Gly Leu Pro Ser Ala Asp 
385                 390                 395                 400 


Ala Pro Ser Leu Lys Glu Ser Leu Pro Leu Tyr Val Val Ala Asp Ile 
                405                 410                 415     


Ala Thr Ser Phe Thr Val Leu Val Gly Ile Phe Phe Pro Ser Val Thr 
            420                 425                 430         


Gly Ile Met Ala Gly Ser Asn Arg Ser Gly Asp Leu Arg Asp Ala Gln 
        435                 440                 445             


Lys Ser Ile Pro Val Gly Thr Ile Leu Ala Ile Ile Thr Thr Ser Leu 
    450                 455                 460                 


Val Tyr Phe Ser Ser Val Val Leu Phe Gly Ala Cys Ile Glu Gly Val 
465                 470                 475                 480 


Val Leu Arg Asp Lys Tyr Gly Asp Gly Val Ser Arg Asn Leu Val Val 
                485                 490                 495     


Gly Thr Leu Ala Trp Pro Ser Pro Trp Val Ile Val Ile Gly Ser Phe 
            500                 505                 510         


Phe Ser Thr Cys Gly Ala Gly Leu Gln Ser Leu Thr Gly Ala Pro Arg 
        515                 520                 525             


Leu Leu Gln Ala Ile Ala Lys Asp Asn Ile Ile Pro Phe Leu Arg Val 
    530                 535                 540                 


Phe Gly His Gly Lys Val Asn Gly Glu Pro Thr Trp Ala Leu Leu Leu 
545                 550                 555                 560 


Thr Ala Leu Ile Ala Glu Leu Gly Ile Leu Ile Ala Ser Leu Asp Met 
                565                 570                 575     


Val Ala Pro Ile Leu Ser Met Phe Phe Leu Met Cys Tyr Leu Phe Val 
            580                 585                 590         


Asn Leu Ala Cys Ala Val Gln Thr Leu Leu Arg Thr Pro Asn Trp Arg 
        595                 600                 605             


Pro Arg Phe Lys Tyr Tyr His Trp Ala Leu Ser Phe Leu Gly Met Ser 
    610                 615                 620                 


Leu Cys Leu Ala Leu Met Phe Val Ser Ser Trp Tyr Tyr Ala Leu Val 
625                 630                 635                 640 


Ala Met Leu Ile Ala Gly Met Ile Tyr Lys Tyr Ile Glu Tyr Gln Gly 
                645                 650                 655     


Ala Glu Lys Glu Trp Gly Asp Gly Ile Arg Gly Leu Ser Leu Ser Ala 
            660                 665                 670         


Ala Arg Tyr Ala Leu Leu Arg Leu Glu Glu Gly Pro Pro His Thr Lys 
        675                 680                 685             


Asn Trp Arg Pro Gln Leu Leu Val Leu Leu Lys Leu Asp Glu Asp Leu 
    690                 695                 700                 


His Val Lys Tyr Pro Arg Leu Leu Thr Phe Ala Ser Gln Leu Lys Ala 
705                 710                 715                 720 


Gly Lys Gly Leu Thr Ile Val Gly Ser Val Ile Gln Gly Ser Phe Leu 
                725                 730                 735     


Glu Ser Tyr Gly Glu Ala Gln Ala Ala Glu Gln Thr Ile Lys Asn Met 
            740                 745                 750         


Met Glu Ile Glu Lys Val Lys Gly Phe Cys Gln Val Val Val Ala Ser 
        755                 760                 765             


Lys Val Arg Glu Gly Leu Ala His Leu Ile Gln Ser Cys Gly Leu Gly 
    770                 775                 780                 


Gly Met Arg His Asn Ser Val Val Leu Gly Trp Pro Tyr Gly Trp Arg 
785                 790                 795                 800 


Gln Ser Glu Asp Pro Arg Ala Trp Lys Thr Phe Ile Asp Thr Val Arg 
                805                 810                 815     


Cys Thr Thr Ala Ala His Leu Ala Leu Leu Val Pro Lys Asn Ile Ala 
            820                 825                 830         


Phe Tyr Pro Ser Asn His Glu Arg Tyr Leu Glu Gly His Ile Asp Val 
        835                 840                 845             


Trp Trp Ile Val His Asp Gly Gly Met Leu Met Leu Leu Pro Phe Leu 
    850                 855                 860                 


Leu Arg Gln His Lys Val Trp Arg Lys Cys Arg Met Arg Ile Phe Thr 
865                 870                 875                 880 


Val Ala Gln Met Asp Asp Asn Ser Ile Gln Met Lys Lys Asp Leu Ala 
                885                 890                 895     


Val Phe Leu Tyr His Leu Arg Leu Glu Ala Glu Val Glu Val Val Glu 
            900                 905                 910         


Met His Asn Ser Asp Ile Ser Ala Tyr Thr Tyr Glu Arg Thr Leu Met 
        915                 920                 925             


Met Glu Gln Arg Ser Gln Met Leu Arg Gln Met Arg Leu Thr Lys Thr 
    930                 935                 940                 


Glu Arg Glu Arg Glu Ala Gln Leu Val Lys Asp Arg His Ser Ala Leu 
945                 950                 955                 960 


Arg Leu Glu Ser Leu Tyr Ser Asp Glu Glu Asp Glu Ser Ala Val Gly 
                965                 970                 975     


Ala Asp Lys Ile Gln Met Thr Trp Thr Arg Asp Lys Tyr Met Thr Glu 
            980                 985                 990         


Thr Trp Asp Pro Ser His Ala Pro  Asp Asn Phe Arg Glu  Leu Val His 
        995                 1000                 1005             


Ile Lys  Pro Asp Gln Ser Asn  Val Arg Arg Met His  Thr Ala Val 
    1010                 1015                 1020             


Lys Leu  Asn Glu Val Ile Val  Thr Arg Ser His Asp  Ala Arg Leu 
    1025                 1030                 1035             


Val Leu  Leu Asn Met Pro Gly  Pro Pro Arg Asn Ser  Glu Gly Asp 
    1040                 1045                 1050             


Glu Asn  Tyr Met Glu Phe Leu  Glu Val Leu Thr Glu  Gly Leu Glu 
    1055                 1060                 1065             


Arg Val  Leu Leu Val Arg Gly  Gly Gly Arg Glu Val  Ile Thr Ile 
    1070                 1075                 1080             


Tyr Ser  
    1085 


<210>  3208
<211>  708
<212>  PRT
<213>  Homo sapiens

<400>  3208

Met Gly Met Ser Lys Ser His Ser Phe Phe Gly Tyr Pro Leu Ser Ile 
1               5                   10                  15      


Phe Phe Ile Val Val Asn Glu Phe Cys Glu Arg Phe Ser Tyr Tyr Gly 
            20                  25                  30          


Met Arg Ala Ile Leu Ile Leu Tyr Phe Thr Asn Phe Ile Ser Trp Asp 
        35                  40                  45              


Asp Asn Leu Ser Thr Ala Ile Tyr His Thr Phe Val Ala Leu Cys Tyr 
    50                  55                  60                  


Leu Thr Pro Ile Leu Gly Ala Leu Ile Ala Asp Ser Trp Leu Gly Lys 
65                  70                  75                  80  


Phe Lys Thr Ile Val Ser Leu Ser Ile Val Tyr Thr Ile Gly Gln Ala 
                85                  90                  95      


Val Thr Ser Val Ser Ser Ile Asn Asp Leu Thr Asp His Asn His Asp 
            100                 105                 110         


Gly Thr Pro Asp Ser Leu Pro Val His Val Val Leu Ser Leu Ile Gly 
        115                 120                 125             


Leu Ala Leu Ile Ala Leu Gly Thr Gly Gly Ile Lys Pro Cys Val Ser 
    130                 135                 140                 


Ala Phe Gly Gly Asp Gln Phe Glu Glu Gly Gln Glu Lys Gln Arg Asn 
145                 150                 155                 160 


Arg Phe Phe Ser Ile Phe Tyr Leu Ala Ile Asn Ala Gly Ser Leu Leu 
                165                 170                 175     


Ser Thr Ile Ile Thr Pro Met Leu Arg Val Gln Gln Cys Gly Ile His 
            180                 185                 190         


Ser Lys Gln Ala Cys Tyr Pro Leu Ala Phe Gly Val Pro Ala Ala Leu 
        195                 200                 205             


Met Ala Val Ala Leu Ile Val Phe Val Leu Gly Ser Gly Met Tyr Lys 
    210                 215                 220                 


Lys Phe Lys Pro Gln Gly Asn Ile Met Gly Lys Val Ala Lys Cys Ile 
225                 230                 235                 240 


Gly Phe Ala Ile Lys Asn Arg Phe Arg His Arg Ser Lys Ala Phe Pro 
                245                 250                 255     


Lys Arg Glu His Trp Leu Asp Trp Ala Lys Glu Lys Tyr Asp Glu Arg 
            260                 265                 270         


Leu Ile Ser Gln Ile Lys Met Val Thr Arg Val Met Phe Leu Tyr Ile 
        275                 280                 285             


Pro Leu Pro Met Phe Trp Ala Leu Phe Asp Gln Gln Gly Ser Arg Trp 
    290                 295                 300                 


Thr Leu Gln Ala Thr Thr Met Ser Gly Lys Ile Gly Ala Leu Glu Ile 
305                 310                 315                 320 


Gln Pro Asp Gln Met Gln Thr Val Asn Ala Ile Leu Ile Val Ile Met 
                325                 330                 335     


Val Pro Ile Phe Asp Ala Val Leu Tyr Pro Leu Ile Ala Lys Cys Gly 
            340                 345                 350         


Phe Asn Phe Thr Ser Leu Lys Lys Met Ala Val Gly Met Val Leu Ala 
        355                 360                 365             


Ser Met Ala Phe Val Val Ala Ala Ile Val Gln Val Glu Ile Asp Lys 
    370                 375                 380                 


Thr Leu Pro Val Phe Pro Lys Gly Asn Glu Val Gln Ile Lys Val Leu 
385                 390                 395                 400 


Asn Ile Gly Asn Asn Thr Met Asn Ile Ser Leu Pro Gly Glu Met Val 
                405                 410                 415     


Thr Leu Gly Pro Met Ser Gln Thr Asn Ala Phe Met Thr Phe Asp Val 
            420                 425                 430         


Asn Lys Leu Thr Arg Ile Asn Ile Ser Ser Pro Gly Ser Pro Val Thr 
        435                 440                 445             


Ala Val Thr Asp Asp Phe Lys Gln Gly Gln Arg His Thr Leu Leu Val 
    450                 455                 460                 


Trp Ala Pro Asn His Tyr Gln Val Val Lys Asp Gly Leu Asn Gln Lys 
465                 470                 475                 480 


Pro Glu Lys Gly Glu Asn Gly Ile Arg Phe Val Asn Thr Phe Asn Glu 
                485                 490                 495     


Leu Ile Thr Ile Thr Met Ser Gly Lys Val Tyr Ala Asn Ile Ser Ser 
            500                 505                 510         


Tyr Asn Ala Ser Thr Tyr Gln Phe Phe Pro Ser Gly Ile Lys Gly Phe 
        515                 520                 525             


Thr Ile Ser Ser Thr Glu Ile Pro Pro Gln Cys Gln Pro Asn Phe Asn 
    530                 535                 540                 


Thr Phe Tyr Leu Glu Phe Gly Ser Ala Tyr Thr Tyr Ile Val Gln Arg 
545                 550                 555                 560 


Lys Asn Asp Ser Cys Pro Glu Val Lys Val Phe Glu Asp Ile Ser Ala 
                565                 570                 575     


Asn Thr Val Asn Met Ala Leu Gln Ile Pro Gln Tyr Phe Leu Leu Thr 
            580                 585                 590         


Cys Gly Glu Val Val Phe Ser Val Thr Gly Leu Glu Phe Ser Tyr Ser 
        595                 600                 605             


Gln Ala Pro Ser Asn Met Lys Ser Val Leu Gln Ala Gly Trp Leu Leu 
    610                 615                 620                 


Thr Val Ala Val Gly Asn Ile Ile Val Leu Ile Val Ala Gly Ala Gly 
625                 630                 635                 640 


Gln Phe Ser Lys Gln Trp Ala Glu Tyr Ile Leu Phe Ala Ala Leu Leu 
                645                 650                 655     


Leu Val Val Cys Val Ile Phe Ala Ile Met Ala Arg Phe Tyr Thr Tyr 
            660                 665                 670         


Ile Asn Pro Ala Glu Ile Glu Ala Gln Phe Asp Glu Asp Glu Lys Lys 
        675                 680                 685             


Asn Arg Leu Glu Lys Ser Asn Pro Tyr Phe Met Ser Gly Ala Asn Ser 
    690                 695                 700                 


Gln Lys Gln Met 
705             


<210>  3209
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  3209

Met Gly Lys Asn Lys Gln Pro Arg Gly Gln Gln Arg Gln Gly Gly Pro 
1               5                   10                  15      


Pro Ala Ala Asp Ala Ala Gly Pro Asp Asp Met Glu Pro Lys Lys Gly 
            20                  25                  30          


Thr Gly Ala Pro Lys Glu Cys Gly Glu Glu Glu Pro Arg Thr Cys Cys 
        35                  40                  45              


Gly Cys Arg Phe Pro Leu Leu Leu Ala Leu Leu Gln Leu Ala Leu Gly 
    50                  55                  60                  


Ile Ala Val Thr Val Val Gly Phe Leu Met Ala Ser Ile Ser Ser Ser 
65                  70                  75                  80  


Leu Leu Val Arg Asp Thr Pro Phe Trp Ala Gly Ile Ile Val Cys Leu 
                85                  90                  95      


Val Ala Tyr Leu Gly Leu Phe Met Leu Cys Val Ser Tyr Gln Val Asp 
            100                 105                 110         


Glu Arg Thr Cys Ile Gln Phe Ser Met Lys Leu Leu Tyr Phe Leu Leu 
        115                 120                 125             


Ser Ala Leu Gly Leu Thr Val Cys Val Leu Ala Val Ala Phe Ala Ala 
    130                 135                 140                 


His His Tyr Ser Gln Leu Thr Gln Phe Thr Cys Glu Thr Thr Leu Asp 
145                 150                 155                 160 


Ser Cys Gln Cys Lys Leu Pro Ser Ser Glu Pro Leu Ser Arg Thr Phe 
                165                 170                 175     


Val Tyr Arg Asp Val Thr Asp Cys Thr Ser Val Thr Gly Thr Phe Lys 
            180                 185                 190         


Leu Phe Leu Leu Ile Gln Met Ile Leu Asn Leu Val Cys Gly Leu Val 
        195                 200                 205             


Cys Leu Leu Ala Cys Phe Val Met Trp Lys His Arg Tyr Gln Val Phe 
    210                 215                 220                 


Tyr Val Gly Val Arg Ile Cys Ser Leu Thr Ala Ser Glu Gly Pro Gln 
225                 230                 235                 240 


Gln Lys Ile 
            


<210>  3210
<211>  621
<212>  PRT
<213>  Homo sapiens

<400>  3210

Met Ala Glu Leu Thr Val Glu Val Arg Gly Ser Asn Gly Ala Phe Tyr 
1               5                   10                  15      


Lys Gly Phe Ile Lys Asp Val His Glu Asp Ser Leu Thr Val Val Phe 
            20                  25                  30          


Glu Asn Asn Trp Gln Pro Glu Arg Gln Val Pro Phe Asn Glu Val Arg 
        35                  40                  45              


Leu Pro Pro Pro Pro Asp Ile Lys Lys Glu Ile Ser Glu Gly Asp Glu 
    50                  55                  60                  


Val Glu Val Tyr Ser Arg Ala Asn Asp Gln Glu Pro Cys Gly Trp Trp 
65                  70                  75                  80  


Leu Ala Lys Val Arg Met Met Lys Gly Glu Phe Tyr Val Ile Glu Tyr 
                85                  90                  95      


Ala Ala Cys Asp Ala Thr Tyr Asn Glu Ile Val Thr Phe Glu Arg Leu 
            100                 105                 110         


Arg Pro Val Asn Gln Asn Lys Thr Val Lys Lys Asn Thr Phe Phe Lys 
        115                 120                 125             


Cys Thr Val Asp Val Pro Glu Asp Leu Arg Glu Ala Cys Ala Asn Glu 
    130                 135                 140                 


Asn Ala His Lys Asp Phe Lys Lys Ala Val Gly Ala Cys Arg Ile Phe 
145                 150                 155                 160 


Tyr His Pro Glu Thr Thr Gln Leu Met Ile Leu Ser Ala Ser Glu Ala 
                165                 170                 175     


Thr Val Lys Arg Val Asn Ile Leu Ser Asp Met His Leu Arg Ser Ile 
            180                 185                 190         


Arg Thr Lys Leu Met Leu Met Ser Arg Asn Glu Glu Ala Thr Lys His 
        195                 200                 205             


Leu Glu Cys Thr Lys Gln Leu Ala Ala Ala Phe His Glu Glu Phe Val 
    210                 215                 220                 


Val Arg Glu Asp Leu Met Gly Leu Ala Ile Gly Thr His Gly Ser Asn 
225                 230                 235                 240 


Ile Gln Gln Ala Arg Lys Val Pro Gly Val Thr Ala Ile Glu Leu Asp 
                245                 250                 255     


Glu Asp Thr Gly Thr Phe Arg Ile Tyr Gly Glu Ser Ala Asp Ala Val 
            260                 265                 270         


Lys Lys Ala Arg Gly Phe Leu Glu Phe Val Glu Asp Phe Ile Gln Val 
        275                 280                 285             


Pro Arg Asn Leu Val Gly Lys Val Ile Gly Lys Asn Gly Lys Val Ile 
    290                 295                 300                 


Gln Glu Ile Val Asp Lys Ser Gly Val Val Arg Val Arg Ile Glu Gly 
305                 310                 315                 320 


Asp Asn Glu Asn Lys Leu Pro Arg Glu Asp Gly Met Val Pro Phe Val 
                325                 330                 335     


Phe Val Gly Thr Lys Glu Ser Ile Gly Asn Val Gln Val Leu Leu Glu 
            340                 345                 350         


Tyr His Ile Ala Tyr Leu Lys Glu Val Glu Gln Leu Arg Met Glu Arg 
        355                 360                 365             


Leu Gln Ile Asp Glu Gln Leu Arg Gln Ile Gly Ser Arg Ser Tyr Ser 
    370                 375                 380                 


Gly Arg Gly Arg Gly Arg Arg Gly Pro Asn Tyr Thr Ser Gly Tyr Gly 
385                 390                 395                 400 


Thr Asn Ser Glu Leu Ser Asn Pro Ser Glu Thr Glu Ser Glu Arg Lys 
                405                 410                 415     


Asp Glu Leu Ser Asp Trp Ser Leu Ala Gly Glu Asp Asp Arg Asp Ser 
            420                 425                 430         


Arg His Gln Arg Asp Ser Arg Arg Arg Pro Gly Gly Arg Gly Arg Ser 
        435                 440                 445             


Val Ser Gly Gly Arg Gly Arg Gly Gly Pro Arg Gly Gly Lys Ser Ser 
    450                 455                 460                 


Ile Ser Ser Val Leu Lys Asp Pro Asp Ser Asn Pro Tyr Ser Leu Leu 
465                 470                 475                 480 


Asp Asn Thr Glu Ser Asp Gln Thr Ala Asp Thr Asp Ala Ser Glu Ser 
                485                 490                 495     


His His Ser Thr Asn Arg Arg Arg Arg Ser Arg Arg Arg Arg Thr Asp 
            500                 505                 510         


Glu Asp Ala Val Leu Met Asp Gly Met Thr Glu Ser Asp Thr Ala Ser 
        515                 520                 525             


Val Asn Glu Asn Gly Leu Val Thr Val Ala Asp Tyr Ile Ser Arg Ala 
    530                 535                 540                 


Glu Ser Gln Ser Arg Gln Arg Asn Leu Pro Arg Glu Thr Leu Ala Lys 
545                 550                 555                 560 


Asn Lys Lys Glu Met Ala Lys Asp Val Ile Glu Glu His Gly Pro Ser 
                565                 570                 575     


Glu Lys Ala Ile Asn Gly Pro Thr Ser Ala Ser Gly Asp Asp Ile Ser 
            580                 585                 590         


Lys Leu Gln Arg Thr Pro Gly Glu Glu Lys Ile Asn Thr Leu Lys Glu 
        595                 600                 605             


Glu Asn Thr Gln Glu Ala Ala Val Leu Asn Gly Val Ser 
    610                 615                 620     


<210>  3211
<211>  643
<212>  PRT
<213>  Homo sapiens

<400>  3211

Met Leu Leu Gly Ala Ser Leu Val Gly Val Leu Leu Phe Ser Lys Leu 
1               5                   10                  15      


Val Leu Lys Leu Pro Trp Thr Gln Val Gly Phe Ser Leu Leu Phe Leu 
            20                  25                  30          


Tyr Leu Gly Ser Gly Gly Trp Arg Phe Ile Arg Val Phe Ile Lys Thr 
        35                  40                  45              


Ile Arg Arg Asp Ile Phe Gly Gly Leu Val Leu Leu Lys Val Lys Ala 
    50                  55                  60                  


Lys Val Arg Gln Cys Leu Gln Glu Arg Arg Thr Val Pro Ile Leu Phe 
65                  70                  75                  80  


Ala Ser Thr Val Arg Arg His Pro Asp Lys Thr Ala Leu Ile Phe Glu 
                85                  90                  95      


Gly Thr Asp Thr His Trp Thr Phe Arg Gln Leu Asp Glu Tyr Ser Ser 
            100                 105                 110         


Ser Val Ala Asn Phe Leu Gln Ala Arg Gly Leu Ala Ser Gly Asp Val 
        115                 120                 125             


Ala Ala Ile Phe Met Glu Asn Arg Asn Glu Phe Val Gly Leu Trp Leu 
    130                 135                 140                 


Gly Met Ala Lys Leu Gly Val Glu Ala Ala Leu Ile Asn Thr Asn Leu 
145                 150                 155                 160 


Arg Arg Asp Ala Leu Leu His Cys Leu Thr Thr Ser Arg Ala Arg Ala 
                165                 170                 175     


Leu Val Phe Gly Ser Glu Met Ala Ser Ala Ile Cys Glu Val His Ala 
            180                 185                 190         


Ser Leu Asp Pro Ser Leu Ser Leu Phe Cys Ser Gly Ser Trp Glu Pro 
        195                 200                 205             


Gly Ala Val Pro Pro Ser Thr Glu His Leu Asp Pro Leu Leu Lys Asp 
    210                 215                 220                 


Ala Pro Lys His Leu Pro Ser Cys Pro Asp Lys Gly Phe Thr Asp Lys 
225                 230                 235                 240 


Leu Phe Tyr Ile Tyr Thr Ser Gly Thr Thr Gly Leu Pro Lys Ala Ala 
                245                 250                 255     


Ile Val Val His Ser Arg Tyr Tyr Arg Met Ala Ala Leu Val Tyr Tyr 
            260                 265                 270         


Gly Phe Arg Met Arg Pro Asn Asp Ile Val Tyr Asp Cys Leu Pro Leu 
        275                 280                 285             


Tyr His Ser Ala Gly Asn Ile Val Gly Ile Gly Gln Cys Leu Leu His 
    290                 295                 300                 


Gly Met Thr Val Val Ile Arg Lys Lys Phe Ser Ala Ser Arg Phe Trp 
305                 310                 315                 320 


Asp Asp Cys Ile Lys Tyr Asn Cys Thr Ile Val Gln Tyr Ile Gly Glu 
                325                 330                 335     


Leu Cys Arg Tyr Leu Leu Asn Gln Pro Pro Arg Glu Ala Glu Asn Gln 
            340                 345                 350         


His Gln Val Arg Met Ala Leu Gly Asn Gly Leu Arg Gln Ser Ile Trp 
        355                 360                 365             


Thr Asn Phe Ser Ser Arg Phe His Ile Pro Gln Val Ala Glu Phe Tyr 
    370                 375                 380                 


Gly Ala Thr Glu Cys Asn Cys Ser Leu Gly Asn Phe Asp Ser Gln Val 
385                 390                 395                 400 


Gly Ala Cys Gly Phe Asn Ser Arg Ile Leu Ser Phe Val Tyr Pro Ile 
                405                 410                 415     


Arg Leu Val Arg Val Asn Glu Asp Thr Met Glu Leu Ile Arg Gly Pro 
            420                 425                 430         


Asp Gly Val Cys Ile Pro Cys Gln Pro Gly Glu Pro Gly Gln Leu Val 
        435                 440                 445             


Gly Arg Ile Ile Gln Lys Asp Pro Leu Arg Arg Phe Asp Gly Tyr Leu 
    450                 455                 460                 


Asn Gln Gly Ala Asn Asn Lys Lys Ile Ala Lys Asp Val Phe Lys Lys 
465                 470                 475                 480 


Gly Asp Gln Ala Tyr Leu Thr Gly Asp Val Leu Val Met Asp Glu Leu 
                485                 490                 495     


Gly Tyr Leu Tyr Phe Arg Asp Arg Thr Gly Asp Thr Phe Arg Trp Lys 
            500                 505                 510         


Gly Glu Asn Val Ser Thr Thr Glu Val Glu Gly Thr Leu Ser Arg Leu 
        515                 520                 525             


Leu Asp Met Ala Asp Val Ala Val Tyr Gly Val Glu Val Pro Gly Thr 
    530                 535                 540                 


Glu Gly Arg Ala Gly Met Ala Ala Val Ala Ser Pro Thr Gly Asn Cys 
545                 550                 555                 560 


Asp Leu Glu Arg Phe Ala Gln Val Leu Glu Lys Glu Leu Pro Leu Tyr 
                565                 570                 575     


Ala Arg Pro Ile Phe Leu Arg Leu Leu Pro Glu Leu His Lys Thr Gly 
            580                 585                 590         


Thr Tyr Lys Phe Gln Lys Thr Glu Leu Arg Lys Glu Gly Phe Asp Pro 
        595                 600                 605             


Ala Ile Val Lys Asp Pro Leu Phe Tyr Leu Asp Ala Gln Lys Gly Arg 
    610                 615                 620                 


Tyr Val Pro Leu Asp Gln Glu Ala Tyr Ser Arg Ile Gln Ala Gly Glu 
625                 630                 635                 640 


Glu Lys Leu 
            


<210>  3212
<211>  368
<212>  PRT
<213>  Homo sapiens

<400>  3212

Met Ala Ile Lys Ser Ile Ala Ser Arg Leu Arg Gly Ser Arg Arg Phe 
1               5                   10                  15      


Leu Ser Gly Phe Val Ala Gly Ala Val Val Gly Ala Ala Gly Ala Gly 
            20                  25                  30          


Leu Ala Ala Leu Gln Phe Phe Arg Ser Gln Gly Ala Glu Gly Ala Leu 
        35                  40                  45              


Thr Gly Lys Gln Pro Asp Gly Ser Ala Glu Lys Ala Val Leu Glu Gln 
    50                  55                  60                  


Phe Gly Phe Pro Leu Thr Gly Thr Glu Ala Arg Cys Tyr Thr Asn His 
65                  70                  75                  80  


Ala Leu Ser Tyr Asp Gln Ala Lys Arg Val Pro Arg Trp Val Leu Glu 
                85                  90                  95      


His Ile Ser Lys Ser Lys Ile Met Gly Asp Ala Asp Arg Lys His Cys 
            100                 105                 110         


Lys Phe Lys Pro Asp Pro Asn Ile Pro Pro Thr Phe Ser Ala Phe Asn 
        115                 120                 125             


Glu Asp Tyr Val Gly Ser Gly Trp Ser Arg Gly His Met Ala Pro Ala 
    130                 135                 140                 


Gly Asn Asn Lys Phe Ser Ser Lys Ala Met Ala Glu Thr Phe Tyr Leu 
145                 150                 155                 160 


Ser Asn Ile Val Pro Gln Asp Phe Asp Asn Asn Ser Gly Tyr Trp Asn 
                165                 170                 175     


Arg Ile Glu Met Tyr Cys Arg Glu Leu Thr Glu Arg Phe Glu Asp Val 
            180                 185                 190         


Trp Val Val Ser Gly Pro Leu Thr Leu Pro Gln Thr Arg Gly Asp Gly 
        195                 200                 205             


Lys Lys Ile Val Ser Tyr Gln Val Ile Gly Glu Asp Asn Val Ala Val 
    210                 215                 220                 


Pro Ser His Leu Tyr Lys Val Ile Leu Ala Arg Arg Ser Ser Val Ser 
225                 230                 235                 240 


Thr Glu Pro Leu Ala Leu Gly Ala Phe Val Val Pro Asn Glu Ala Ile 
                245                 250                 255     


Gly Phe Gln Pro Gln Leu Thr Glu Phe Gln Val Ser Leu Gln Asp Leu 
            260                 265                 270         


Glu Lys Leu Ser Gly Leu Val Phe Phe Pro His Leu Asp Arg Thr Ser 
        275                 280                 285             


Asp Ile Arg Asn Ile Cys Ser Val Asp Thr Cys Lys Leu Leu Asp Phe 
    290                 295                 300                 


Gln Glu Phe Thr Leu Tyr Leu Ser Thr Arg Lys Ile Glu Gly Ala Arg 
305                 310                 315                 320 


Ser Val Leu Arg Leu Glu Lys Ile Met Glu Asn Leu Lys Asn Ala Glu 
                325                 330                 335     


Ile Glu Pro Asp Asp Tyr Phe Met Ser Arg Tyr Glu Lys Lys Leu Glu 
            340                 345                 350         


Glu Leu Lys Ala Lys Glu Gln Ser Gly Thr Gln Ile Arg Lys Pro Ser 
        355                 360                 365             


<210>  3213
<211>  731
<212>  PRT
<213>  Homo sapiens

<400>  3213

Met Ser Trp Phe Val Asp Leu Ala Gly Lys Ala Glu Asp Leu Leu Asn 
1               5                   10                  15      


Arg Val Asp Gln Gly Ala Ala Thr Ala Leu Ser Arg Lys Asp Asn Ala 
            20                  25                  30          


Ser Asn Ile Tyr Ser Lys Asn Thr Asp Tyr Thr Glu Leu His Gln Gln 
        35                  40                  45              


Asn Thr Asp Leu Ile Tyr Gln Thr Gly Pro Lys Ser Thr Tyr Ile Ser 
    50                  55                  60                  


Ser Ala Ala Asp Asn Ile Arg Asn Gln Lys Ala Thr Ile Leu Ala Gly 
65                  70                  75                  80  


Thr Ala Asn Val Lys Val Gly Ser Arg Thr Pro Val Glu Ala Ser His 
                85                  90                  95      


Pro Val Glu Asn Ala Ser Val Pro Arg Pro Ser Ser His Phe Val Arg 
            100                 105                 110         


Arg Lys Lys Ser Glu Pro Asp Asp Glu Leu Leu Phe Asp Phe Leu Asn 
        115                 120                 125             


Ser Ser Gln Lys Glu Pro Thr Gly Arg Val Glu Ile Arg Lys Glu Lys 
    130                 135                 140                 


Gly Lys Thr Pro Val Phe Gln Ser Ser Gln Thr Ser Ser Val Ser Ser 
145                 150                 155                 160 


Val Asn Pro Ser Val Thr Thr Ile Lys Thr Ile Glu Glu Asn Ser Phe 
                165                 170                 175     


Gly Ser Gln Thr His Glu Ala Ala Ser Asn Ser Asp Ser Ser His Glu 
            180                 185                 190         


Gly Gln Glu Glu Ser Ser Lys Glu Asn Val Ser Ser Asn Ala Ala Cys 
        195                 200                 205             


Pro Asp His Thr Pro Thr Pro Asn Asp Asp Gly Lys Ser His Glu Leu 
    210                 215                 220                 


Ser Asn Leu Arg Leu Glu Asn Gln Leu Leu Arg Asn Glu Val Gln Ser 
225                 230                 235                 240 


Leu Asn Gln Glu Met Ala Ser Leu Leu Gln Arg Ser Lys Glu Thr Gln 
                245                 250                 255     


Glu Glu Leu Asn Lys Ala Arg Ala Arg Val Glu Lys Trp Asn Ala Asp 
            260                 265                 270         


His Ser Lys Ser Asp Arg Met Thr Arg Gly Leu Arg Ala Gln Val Asp 
        275                 280                 285             


Asp Leu Thr Glu Ala Val Ala Ala Lys Asp Ser Gln Leu Ala Val Leu 
    290                 295                 300                 


Lys Val Arg Leu Gln Glu Ala Asp Gln Leu Leu Ser Thr Arg Thr Glu 
305                 310                 315                 320 


Ala Leu Glu Ala Leu Gln Ser Glu Lys Ser Arg Ile Met Gln Asp Gln 
                325                 330                 335     


Ser Glu Gly Asn Ser Leu Gln Asn Gln Ala Leu Gln Thr Leu Gln Glu 
            340                 345                 350         


Arg Leu His Glu Ala Asp Ala Thr Leu Lys Arg Glu Gln Glu Ser Tyr 
        355                 360                 365             


Lys Gln Met Gln Ser Glu Phe Ala Ala Arg Leu Asn Lys Val Glu Met 
    370                 375                 380                 


Glu Arg Gln Asn Leu Ala Glu Ala Ile Thr Leu Ala Glu Arg Lys Tyr 
385                 390                 395                 400 


Ser Asp Glu Lys Lys Arg Val Asp Glu Leu Gln Gln Gln Val Lys Leu 
                405                 410                 415     


Tyr Lys Leu Asn Leu Glu Ser Ser Lys Gln Glu Leu Ile Asp Tyr Lys 
            420                 425                 430         


Gln Lys Ala Thr Arg Ile Leu Gln Ser Lys Glu Lys Leu Ile Asn Ser 
        435                 440                 445             


Leu Lys Glu Gly Ser Gly Phe Glu Gly Leu Asp Ser Ser Thr Ala Ser 
    450                 455                 460                 


Ser Met Glu Leu Glu Glu Leu Arg His Glu Lys Glu Met Gln Arg Glu 
465                 470                 475                 480 


Glu Ile Gln Lys Leu Met Gly Gln Ile His Gln Leu Arg Ser Glu Leu 
                485                 490                 495     


Gln Asp Met Glu Ala Gln Gln Val Asn Glu Ala Glu Ser Ala Arg Glu 
            500                 505                 510         


Gln Leu Gln Asp Leu His Asp Gln Ile Ala Gly Gln Lys Ala Ser Lys 
        515                 520                 525             


Gln Glu Leu Glu Thr Glu Leu Glu Arg Leu Lys Gln Glu Phe His Tyr 
    530                 535                 540                 


Ile Glu Glu Asp Leu Tyr Arg Thr Lys Asn Thr Leu Gln Ser Arg Ile 
545                 550                 555                 560 


Lys Asp Arg Asp Glu Glu Ile Gln Lys Leu Arg Asn Gln Leu Thr Asn 
                565                 570                 575     


Lys Thr Leu Ser Asn Ser Ser Gln Ser Glu Leu Glu Asn Arg Leu His 
            580                 585                 590         


Gln Leu Thr Glu Thr Leu Ile Gln Lys Gln Thr Met Leu Glu Ser Leu 
        595                 600                 605             


Ser Thr Glu Lys Asn Ser Leu Val Phe Gln Leu Glu Arg Leu Glu Gln 
    610                 615                 620                 


Gln Met Asn Ser Ala Ser Gly Ser Ser Ser Asn Gly Ser Ser Ile Asn 
625                 630                 635                 640 


Met Ser Gly Ile Asp Asn Gly Glu Gly Thr Arg Leu Arg Asn Val Pro 
                645                 650                 655     


Val Leu Phe Asn Asp Thr Glu Thr Asn Leu Ala Gly Met Tyr Gly Lys 
            660                 665                 670         


Val Arg Lys Ala Ala Ser Ser Ile Asp Gln Phe Ser Ile Arg Leu Gly 
        675                 680                 685             


Ile Phe Leu Arg Arg Tyr Pro Ile Ala Arg Val Phe Val Ile Ile Tyr 
    690                 695                 700                 


Met Ala Leu Leu His Leu Trp Val Met Ile Val Leu Leu Thr Tyr Thr 
705                 710                 715                 720 


Pro Glu Met His His Asp Gln Pro Tyr Gly Lys 
                725                 730     


<210>  3214
<211>  650
<212>  PRT
<213>  Homo sapiens

<400>  3214

Met Met Gly Ile Gly Lys Asn Thr Thr Ser Lys Ser Met Glu Ala Gly 
1               5                   10                  15      


Ser Ser Thr Glu Gly Lys Tyr Glu Asp Glu Ala Lys His Pro Ala Phe 
            20                  25                  30          


Phe Thr Leu Pro Val Val Ile Asn Gly Gly Ala Thr Ser Ser Gly Glu 
        35                  40                  45              


Gln Asp Asn Glu Asp Thr Glu Leu Met Ala Ile Tyr Thr Thr Glu Asn 
    50                  55                  60                  


Gly Ile Ala Glu Lys Ser Ser Leu Ala Glu Thr Leu Asp Ser Thr Gly 
65                  70                  75                  80  


Ser Leu Asp Pro Gln Arg Ser Asp Met Ile Tyr Thr Ile Glu Asp Val 
                85                  90                  95      


Pro Pro Trp Tyr Leu Cys Ile Phe Leu Gly Leu Gln His Tyr Leu Thr 
            100                 105                 110         


Cys Phe Ser Gly Thr Ile Ala Val Pro Phe Leu Leu Ala Asp Ala Met 
        115                 120                 125             


Cys Val Gly Tyr Asp Gln Trp Ala Thr Ser Gln Leu Ile Gly Thr Ile 
    130                 135                 140                 


Phe Phe Cys Val Gly Ile Thr Thr Leu Leu Gln Thr Thr Phe Gly Cys 
145                 150                 155                 160 


Arg Leu Pro Leu Phe Gln Ala Ser Ala Phe Ala Phe Leu Ala Pro Ala 
                165                 170                 175     


Arg Ala Ile Leu Ser Leu Asp Lys Trp Lys Cys Asn Thr Thr Asp Val 
            180                 185                 190         


Ser Val Ala Asn Gly Thr Ala Glu Leu Leu His Thr Glu His Ile Trp 
        195                 200                 205             


Tyr Pro Arg Ile Arg Glu Ile Gln Gly Ala Ile Ile Met Ser Ser Leu 
    210                 215                 220                 


Ile Glu Val Val Ile Gly Leu Leu Gly Leu Pro Gly Ala Leu Leu Lys 
225                 230                 235                 240 


Tyr Ile Gly Pro Leu Thr Ile Thr Pro Thr Val Ala Leu Ile Gly Leu 
                245                 250                 255     


Ser Gly Phe Gln Ala Ala Gly Glu Arg Ala Gly Lys His Trp Gly Ile 
            260                 265                 270         


Ala Met Leu Thr Ile Phe Leu Val Leu Leu Phe Ser Gln Tyr Ala Arg 
        275                 280                 285             


Asn Val Lys Phe Pro Leu Pro Ile Tyr Lys Ser Lys Lys Gly Trp Thr 
    290                 295                 300                 


Ala Tyr Lys Leu Gln Leu Phe Lys Met Phe Pro Ile Ile Leu Ala Ile 
305                 310                 315                 320 


Leu Val Ser Trp Leu Leu Cys Phe Ile Phe Thr Val Thr Asp Val Phe 
                325                 330                 335     


Pro Pro Asp Ser Thr Lys Tyr Gly Phe Tyr Ala Arg Thr Asp Ala Arg 
            340                 345                 350         


Gln Gly Val Leu Leu Val Ala Pro Trp Phe Lys Val Pro Tyr Pro Phe 
        355                 360                 365             


Gln Trp Gly Leu Pro Thr Val Ser Ala Ala Gly Val Ile Gly Met Leu 
    370                 375                 380                 


Ser Ala Val Val Ala Ser Ile Ile Glu Ser Ile Gly Asp Tyr Tyr Ala 
385                 390                 395                 400 


Cys Ala Arg Leu Ser Cys Ala Pro Pro Pro Pro Ile His Ala Ile Asn 
                405                 410                 415     


Arg Gly Ile Phe Val Glu Gly Leu Ser Cys Val Leu Asp Gly Ile Phe 
            420                 425                 430         


Gly Thr Gly Asn Gly Ser Thr Ser Ser Ser Pro Asn Ile Gly Val Leu 
        435                 440                 445             


Gly Ile Thr Lys Val Gly Ser Arg Arg Val Ile Gln Cys Gly Ala Ala 
    450                 455                 460                 


Leu Met Leu Ala Leu Gly Met Ile Gly Lys Phe Ser Ala Leu Phe Ala 
465                 470                 475                 480 


Ser Leu Pro Asp Pro Val Leu Gly Ala Leu Phe Cys Thr Leu Phe Gly 
                485                 490                 495     


Met Ile Thr Ala Val Gly Leu Ser Asn Leu Gln Phe Ile Asp Leu Asn 
            500                 505                 510         


Ser Ser Arg Asn Leu Phe Val Leu Gly Phe Ser Ile Phe Phe Gly Leu 
        515                 520                 525             


Val Leu Pro Ser Tyr Leu Arg Gln Asn Pro Leu Val Thr Gly Ile Thr 
    530                 535                 540                 


Gly Ile Asp Gln Val Leu Asn Val Leu Leu Thr Thr Ala Met Phe Val 
545                 550                 555                 560 


Gly Gly Cys Val Ala Phe Ile Leu Asp Asn Thr Ile Pro Gly Thr Pro 
                565                 570                 575     


Glu Glu Arg Gly Ile Arg Lys Trp Lys Lys Gly Val Gly Lys Gly Asn 
            580                 585                 590         


Lys Ser Leu Asp Gly Met Glu Ser Tyr Asn Leu Pro Phe Gly Met Asn 
        595                 600                 605             


Ile Ile Lys Lys Tyr Arg Cys Phe Ser Tyr Leu Pro Ile Ser Pro Thr 
    610                 615                 620                 


Phe Val Gly Tyr Thr Trp Lys Gly Leu Arg Lys Ser Asp Asn Ser Arg 
625                 630                 635                 640 


Ser Ser Asp Glu Asp Ser Gln Ala Thr Gly 
                645                 650 


<210>  3215
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  3215

Met Arg Ser Gly Cys Val Val Val His Val Trp Ile Leu Ala Gly Leu 
1               5                   10                  15      


Trp Leu Ala Val Ala Gly Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro 
            20                  25                  30          


His Val His Tyr Gly Trp Gly Asp Pro Ile Arg Leu Arg His Leu Tyr 
        35                  40                  45              


Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala 
    50                  55                  60                  


Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His Ser Leu Leu 
65                  70                  75                  80  


Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys Gly Val His 
                85                  90                  95      


Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met Gln Gly Leu 
            100                 105                 110         


Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro 
        115                 120                 125             


Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu Pro Val Ser 
    130                 135                 140                 


Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu 
145                 150                 155                 160 


Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro Glu Glu Pro 
                165                 170                 175     


Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser Pro Leu 
            180                 185                 190         


Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu Glu Ala 
        195                 200                 205             


Val Arg Ser Pro Ser Phe Glu Lys 
    210                 215     


<210>  3216
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  3216

Met Ala Glu Asp Leu Gly Leu Ser Phe Gly Glu Thr Ala Ser Val Glu 
1               5                   10                  15      


Met Leu Pro Glu His Gly Ser Cys Arg Pro Lys Ala Arg Ser Ser Ser 
            20                  25                  30          


Ala Arg Trp Ala Leu Thr Cys Cys Leu Val Leu Leu Pro Phe Leu Ala 
        35                  40                  45              


Gly Leu Thr Thr Tyr Leu Leu Val Ser Gln Leu Arg Ala Gln Gly Glu 
    50                  55                  60                  


Ala Cys Val Gln Phe Gln Ala Leu Lys Gly Gln Glu Phe Ala Pro Ser 
65                  70                  75                  80  


His Gln Gln Val Tyr Ala Pro Leu Arg Ala Asp Gly Asp Lys Pro Arg 
                85                  90                  95      


Ala His Leu Thr Val Val Arg Gln Thr Pro Thr Gln His Phe Lys Asn 
            100                 105                 110         


Gln Phe Pro Ala Leu His Trp Glu His Glu Leu Gly Leu Ala Phe Thr 
        115                 120                 125             


Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser 
    130                 135                 140                 


Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg Gly Met Thr Ser 
145                 150                 155                 160 


Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser 
                165                 170                 175     


Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr 
            180                 185                 190         


Gln Leu Leu Met Gly Thr Lys Ser Val Cys Glu Val Gly Ser Asn Trp 
        195                 200                 205             


Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu Gln Glu Gly Asp 
    210                 215                 220                 


Lys Leu Met Val Asn Val Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys 
225                 230                 235                 240 


Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu 
                245                 250     


<210>  3217
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  3217

Met Met Thr Lys His Lys Lys Cys Phe Ile Ile Val Gly Val Leu Ile 
1               5                   10                  15      


Thr Thr Asn Ile Ile Thr Leu Ile Val Lys Leu Thr Arg Asp Ser Gln 
            20                  25                  30          


Ser Leu Cys Pro Tyr Asp Trp Ile Gly Phe Gln Asn Lys Cys Tyr Tyr 
        35                  40                  45              


Phe Ser Lys Glu Glu Gly Asp Trp Asn Ser Ser Lys Tyr Asn Cys Ser 
    50                  55                  60                  


Thr Gln His Ala Asp Leu Thr Ile Ile Asp Asn Ile Glu Glu Met Asn 
65                  70                  75                  80  


Phe Leu Arg Arg Tyr Lys Cys Ser Ser Asp His Trp Ile Gly Leu Lys 
                85                  90                  95      


Met Ala Lys Asn Arg Thr Gly Gln Trp Val Asp Gly Ala Thr Phe Thr 
            100                 105                 110         


Lys Ser Phe Gly Met Arg Gly Ser Glu Gly Cys Ala Tyr Leu Ser Asp 
        115                 120                 125             


Asp Gly Ala Ala Thr Ala Arg Cys Tyr Thr Glu Arg Lys Trp Ile Cys 
    130                 135                 140                 


Arg Lys Arg Ile His 
145                 


<210>  3218
<211>  1099
<212>  PRT
<213>  Homo sapiens

<400>  3218

Met Pro His Phe Thr Val Thr Lys Val Glu Asp Pro Glu Glu Gly Ala 
1               5                   10                  15      


Ala Ala Ser Ile Ser Gln Glu Pro Ser Leu Ala Asp Ile Lys Ala Arg 
            20                  25                  30          


Ile Gln Asp Ser Asp Glu Pro Asp Leu Ser Gln Asn Ser Ile Thr Gly 
        35                  40                  45              


Glu His Ser Gln Leu Leu Asp Asp Gly His Lys Lys Ala Arg Asn Ala 
    50                  55                  60                  


Tyr Leu Asn Asn Ser Asn Tyr Glu Glu Gly Asp Glu Tyr Phe Asp Lys 
65                  70                  75                  80  


Asn Leu Ala Leu Phe Glu Glu Glu Met Asp Thr Arg Pro Lys Val Ser 
                85                  90                  95      


Ser Leu Leu Asn Arg Met Ala Asn Tyr Thr Asn Leu Thr Gln Gly Ala 
            100                 105                 110         


Lys Glu His Glu Glu Ala Glu Asn Ile Thr Glu Gly Lys Lys Lys Pro 
        115                 120                 125             


Thr Lys Thr Pro Gln Met Gly Thr Phe Met Gly Val Tyr Leu Pro Cys 
    130                 135                 140                 


Leu Gln Asn Ile Phe Gly Val Ile Leu Phe Leu Arg Leu Thr Trp Val 
145                 150                 155                 160 


Val Gly Thr Ala Gly Val Leu Gln Ala Phe Ala Ile Val Leu Ile Cys 
                165                 170                 175     


Cys Cys Cys Thr Met Leu Thr Ala Ile Ser Met Ser Ala Ile Ala Thr 
            180                 185                 190         


Asn Gly Val Val Pro Ala Gly Gly Ser Tyr Phe Met Ile Ser Arg Ala 
        195                 200                 205             


Leu Gly Pro Glu Phe Gly Gly Ala Val Gly Leu Cys Phe Tyr Leu Gly 
    210                 215                 220                 


Thr Thr Phe Ala Ala Ala Met Tyr Ile Leu Gly Ala Ile Glu Ile Phe 
225                 230                 235                 240 


Leu Val Tyr Ile Val Pro Arg Ala Ala Ile Phe His Ser Asp Asp Ala 
                245                 250                 255     


Leu Lys Glu Ser Ala Ala Met Leu Asn Asn Met Arg Val Tyr Gly Thr 
            260                 265                 270         


Ala Phe Leu Val Leu Met Val Leu Val Val Phe Ile Gly Val Arg Tyr 
        275                 280                 285             


Val Asn Lys Phe Ala Ser Leu Phe Leu Ala Cys Val Ile Val Ser Ile 
    290                 295                 300                 


Leu Ala Ile Tyr Ala Gly Ala Ile Lys Ser Ser Phe Ala Pro Pro His 
305                 310                 315                 320 


Phe Pro Val Cys Met Leu Gly Asn Arg Thr Leu Ser Ser Arg His Ile 
                325                 330                 335     


Asp Val Cys Ser Lys Thr Lys Glu Ile Asn Asn Met Thr Val Pro Ser 
            340                 345                 350         


Lys Leu Trp Gly Phe Phe Cys Asn Ser Ser Gln Phe Phe Asn Ala Thr 
        355                 360                 365             


Cys Asp Glu Tyr Phe Val His Asn Asn Val Thr Ser Ile Gln Gly Ile 
    370                 375                 380                 


Pro Gly Leu Ala Ser Gly Ile Ile Thr Glu Asn Leu Trp Ser Asn Tyr 
385                 390                 395                 400 


Leu Pro Lys Gly Glu Ile Ile Glu Lys Pro Ser Ala Lys Ser Ser Asp 
                405                 410                 415     


Val Leu Gly Ser Leu Asn His Glu Tyr Val Leu Val Asp Ile Thr Thr 
            420                 425                 430         


Ser Phe Thr Leu Leu Val Gly Ile Phe Phe Pro Ser Val Thr Gly Ile 
        435                 440                 445             


Met Ala Gly Ser Asn Arg Ser Gly Asp Leu Lys Asp Ala Gln Lys Ser 
    450                 455                 460                 


Ile Pro Ile Gly Thr Ile Leu Ala Ile Leu Thr Thr Ser Phe Val Tyr 
465                 470                 475                 480 


Leu Ser Asn Val Val Leu Phe Gly Ala Cys Ile Glu Gly Val Val Leu 
                485                 490                 495     


Arg Asp Lys Phe Gly Asp Ala Val Lys Gly Asn Leu Val Val Gly Thr 
            500                 505                 510         


Leu Ser Trp Pro Ser Pro Trp Val Ile Val Ile Gly Ser Phe Phe Ser 
        515                 520                 525             


Thr Cys Gly Ala Gly Leu Gln Ser Leu Thr Gly Ala Pro Arg Leu Leu 
    530                 535                 540                 


Gln Ala Ile Ala Lys Asp Asn Ile Ile Pro Phe Leu Arg Val Phe Gly 
545                 550                 555                 560 


His Ser Lys Ala Asn Gly Glu Pro Thr Trp Ala Leu Leu Leu Thr Ala 
                565                 570                 575     


Ala Ile Ala Glu Leu Gly Ile Leu Ile Ala Ser Leu Asp Leu Val Ala 
            580                 585                 590         


Pro Ile Leu Ser Met Phe Phe Leu Met Cys Tyr Leu Phe Val Asn Leu 
        595                 600                 605             


Ala Cys Ala Leu Gln Thr Leu Leu Arg Thr Pro Asn Trp Arg Pro Arg 
    610                 615                 620                 


Phe Arg Tyr Tyr His Trp Ala Leu Ser Phe Met Gly Met Ser Ile Cys 
625                 630                 635                 640 


Leu Ala Leu Met Phe Ile Ser Ser Trp Tyr Tyr Ala Ile Val Ala Met 
                645                 650                 655     


Val Ile Ala Gly Met Ile Tyr Lys Tyr Ile Glu Tyr Gln Gly Ala Glu 
            660                 665                 670         


Lys Glu Trp Gly Asp Gly Ile Arg Gly Leu Ser Leu Ser Ala Ala Arg 
        675                 680                 685             


Phe Ala Leu Leu Arg Leu Glu Glu Gly Pro Pro His Thr Lys Asn Trp 
    690                 695                 700                 


Arg Pro Gln Leu Leu Val Leu Leu Lys Leu Asp Glu Asp Leu His Val 
705                 710                 715                 720 


Lys His Pro Arg Leu Leu Thr Phe Ala Ser Gln Leu Lys Ala Gly Lys 
                725                 730                 735     


Gly Leu Thr Ile Val Gly Ser Val Ile Val Gly Asn Phe Leu Glu Asn 
            740                 745                 750         


Tyr Gly Glu Ala Leu Ala Ala Glu Gln Thr Ile Lys His Leu Met Glu 
        755                 760                 765             


Ala Glu Lys Val Lys Gly Phe Cys Gln Leu Val Val Ala Ala Lys Leu 
    770                 775                 780                 


Arg Glu Gly Ile Ser His Leu Ile Gln Ser Cys Gly Leu Gly Gly Met 
785                 790                 795                 800 


Lys His Asn Thr Val Val Met Gly Trp Pro Asn Gly Trp Arg Gln Ser 
                805                 810                 815     


Glu Asp Ala Arg Ala Trp Lys Thr Phe Ile Gly Thr Val Arg Val Thr 
            820                 825                 830         


Thr Ala Ala His Leu Ala Leu Leu Val Ala Lys Asn Ile Ser Phe Phe 
        835                 840                 845             


Pro Ser Asn Val Glu Gln Phe Ser Glu Gly Asn Ile Asp Val Trp Trp 
    850                 855                 860                 


Ile Val His Asp Gly Gly Met Leu Met Leu Leu Pro Phe Leu Leu Lys 
865                 870                 875                 880 


Gln His Lys Val Trp Arg Lys Cys Ser Ile Arg Ile Phe Thr Val Ala 
                885                 890                 895     


Gln Leu Glu Asp Asn Ser Ile Gln Met Lys Lys Asp Leu Ala Thr Phe 
            900                 905                 910         


Leu Tyr His Leu Arg Ile Glu Ala Glu Val Glu Val Val Glu Met His 
        915                 920                 925             


Asp Ser Asp Ile Ser Ala Tyr Thr Tyr Glu Arg Thr Leu Met Met Glu 
    930                 935                 940                 


Gln Arg Ser Gln Met Leu Arg His Met Arg Leu Ser Lys Thr Glu Arg 
945                 950                 955                 960 


Asp Arg Glu Ala Gln Leu Val Lys Asp Arg Asn Ser Met Leu Arg Leu 
                965                 970                 975     


Thr Ser Ile Gly Ser Asp Glu Asp Glu Glu Thr Glu Thr Tyr Gln Glu 
            980                 985                 990         


Lys Val His Met Thr Trp Thr Lys  Asp Lys Tyr Met Ala  Ser Arg Gly 
        995                 1000                 1005             


Gln Lys  Ala Lys Ser Met Glu  Gly Phe Gln Asp Leu  Leu Asn Met 
    1010                 1015                 1020             


Arg Pro  Asp Gln Ser Asn Val  Arg Arg Met His Thr  Ala Val Lys 
    1025                 1030                 1035             


Leu Asn  Glu Val Ile Val Asn  Lys Ser His Glu Ala  Lys Leu Val 
    1040                 1045                 1050             


Leu Leu  Asn Met Pro Gly Pro  Pro Arg Asn Pro Glu  Gly Asp Glu 
    1055                 1060                 1065             


Asn Tyr  Met Glu Phe Leu Glu  Val Leu Thr Glu Gly  Leu Glu Arg 
    1070                 1075                 1080             


Val Leu  Leu Val Arg Gly Gly  Gly Ser Glu Val Ile  Thr Ile Tyr 
    1085                 1090                 1095             


Ser 
    


<210>  3219
<211>  550
<212>  PRT
<213>  Homo sapiens

<400>  3219

Met Val Pro Lys Ala Asp Ser Gly Ala Phe Leu Leu Leu Phe Leu Leu 
1               5                   10                  15      


Val Leu Thr Val Thr Glu Pro Leu Arg Pro Glu Leu Arg Cys Asn Pro 
            20                  25                  30          


Gly Gln Phe Ala Cys Arg Ser Gly Thr Ile Gln Cys Ile Pro Leu Pro 
        35                  40                  45              


Trp Gln Cys Asp Gly Trp Ala Thr Cys Glu Asp Glu Ser Asp Glu Ala 
    50                  55                  60                  


Asn Cys Pro Glu Val Thr Gly Glu Val Arg Pro His His Gly Lys Glu 
65                  70                  75                  80  


Ala Val Asp Pro Arg Gln Gly Arg Ala Arg Gly Gly Asp Pro Ser His 
                85                  90                  95      


Phe His Ala Val Asn Val Ala Gln Pro Val Arg Phe Ser Ser Phe Leu 
            100                 105                 110         


Gly Lys Cys Pro Thr Gly Trp His His Tyr Glu Gly Thr Ala Ser Cys 
        115                 120                 125             


Tyr Arg Val Tyr Leu Ser Gly Glu Asn Tyr Trp Asp Ala Ala Gln Thr 
    130                 135                 140                 


Cys Gln Arg Leu Asn Gly Ser Leu Ala Thr Phe Ser Thr Asp Gln Glu 
145                 150                 155                 160 


Leu Arg Phe Val Leu Ala Gln Glu Trp Asp Gln Pro Glu Arg Ser Phe 
                165                 170                 175     


Gly Trp Lys Asp Gln Arg Lys Leu Trp Val Gly Tyr Gln Tyr Val Ile 
            180                 185                 190         


Thr Gly Arg Asn Arg Ser Leu Glu Gly Arg Trp Glu Val Ala Phe Lys 
        195                 200                 205             


Gly Ser Ser Glu Val Phe Leu Pro Pro Asp Pro Ile Phe Ala Ser Ala 
    210                 215                 220                 


Met Ser Glu Asn Asp Asn Val Phe Cys Ala Gln Leu Gln Cys Phe His 
225                 230                 235                 240 


Phe Pro Thr Leu Arg His His Asp Leu His Ser Trp His Ala Glu Ser 
                245                 250                 255     


Cys Tyr Glu Lys Ser Ser Phe Leu Cys Lys Arg Ser Gln Thr Cys Val 
            260                 265                 270         


Asp Ile Lys Asp Asn Val Val Asp Glu Gly Phe Tyr Phe Thr Pro Lys 
        275                 280                 285             


Gly Asp Asp Pro Cys Leu Ser Cys Thr Cys His Gly Gly Glu Pro Glu 
    290                 295                 300                 


Met Cys Val Ala Ala Leu Cys Glu Arg Pro Gln Gly Cys Gln Gln Tyr 
305                 310                 315                 320 


Arg Lys Asp Pro Lys Glu Cys Cys Lys Phe Met Cys Leu Asp Pro Asp 
                325                 330                 335     


Gly Asn Ser Leu Phe Asp Ser Met Ala Ser Gly Met Arg Leu Val Val 
            340                 345                 350         


Ser Cys Ile Ser Ser Phe Leu Ile Leu Ser Leu Leu Leu Phe Met Val 
        355                 360                 365             


His Arg Leu Arg Gln Arg Arg Arg Glu Arg Ile Glu Ser Leu Ile Gly 
    370                 375                 380                 


Ala Asn Leu His His Phe Asn Leu Gly Arg Arg Ile Pro Gly Phe Asp 
385                 390                 395                 400 


Tyr Gly Pro Asp Gly Phe Gly Thr Gly Leu Thr Pro Leu His Leu Ser 
                405                 410                 415     


Asp Asp Gly Glu Gly Gly Thr Phe His Phe His Asp Pro Pro Pro Pro 
            420                 425                 430         


Tyr Thr Ala Tyr Lys Tyr Pro Asp Ile Gly Gln Pro Asp Asp Pro Pro 
        435                 440                 445             


Pro Pro Tyr Glu Ala Ser Ile His Pro Asp Ser Val Phe Tyr Asp Pro 
    450                 455                 460                 


Ala Asp Asp Asp Ala Phe Glu Pro Val Glu Val Ser Leu Pro Ala Pro 
465                 470                 475                 480 


Gly Asp Gly Gly Ser Glu Gly Ala Leu Leu Arg Arg Leu Glu Gln Pro 
                485                 490                 495     


Leu Pro Thr Ala Gly Ala Ser Leu Ala Asp Leu Glu Asp Ser Ala Asp 
            500                 505                 510         


Ser Ser Ser Ala Leu Leu Val Pro Pro Asp Pro Ala Gln Ser Gly Ser 
        515                 520                 525             


Thr Pro Ala Ala Glu Ala Leu Pro Gly Gly Gly Arg His Ser Arg Ser 
    530                 535                 540                 


Ser Leu Asn Thr Val Val 
545                 550 


<210>  3220
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  3220

Met Leu Gly Leu Cys Gly Gln Arg Leu Pro Ala Ala Trp Val Leu Leu 
1               5                   10                  15      


Leu Leu Pro Phe Leu Pro Leu Leu Leu Leu Ala Ala Pro Ala Pro His 
            20                  25                  30          


Arg Ala Ser Tyr Lys Pro Val Ile Val Val His Gly Leu Phe Asp Ser 
        35                  40                  45              


Ser Tyr Ser Phe Arg His Leu Leu Glu Tyr Ile Asn Glu Thr His Pro 
    50                  55                  60                  


Gly Thr Val Val Thr Val Leu Asp Leu Phe Asp Gly Arg Glu Ser Leu 
65                  70                  75                  80  


Arg Pro Leu Trp Glu Gln Val Gln Gly Phe Arg Glu Ala Val Val Pro 
                85                  90                  95      


Ile Met Ala Lys Ala Pro Gln Gly Val His Leu Ile Cys Tyr Ser Gln 
            100                 105                 110         


Gly Gly Leu Val Cys Arg Ala Leu Leu Ser Val Met Asp Asp His Asn 
        115                 120                 125             


Val Asp Ser Phe Ile Ser Leu Ser Ser Pro Gln Met Gly Gln Tyr Gly 
    130                 135                 140                 


Asp Thr Asp Tyr Leu Lys Trp Leu Phe Pro Thr Ser Met Arg Ser Asn 
145                 150                 155                 160 


Leu Tyr Arg Ile Cys Tyr Ser Pro Trp Gly Gln Glu Phe Ser Ile Cys 
                165                 170                 175     


Asn Tyr Trp His Asp Pro His His Asp Asp Leu Tyr Leu Asn Ala Ser 
            180                 185                 190         


Ser Phe Leu Ala Leu Ile Asn Gly Glu Arg Asp His Pro Asn Ala Thr 
        195                 200                 205             


Val Trp Arg Lys Asn Phe Leu Arg Val Gly His Leu Val Leu Ile Gly 
    210                 215                 220                 


Gly Pro Asp Asp Gly Val Ile Thr Pro Trp Gln Ser Ser Phe Phe Gly 
225                 230                 235                 240 


Phe Tyr Asp Ala Asn Glu Thr Val Leu Glu Met Glu Glu Gln Leu Val 
                245                 250                 255     


Tyr Leu Arg Asp Ser Phe Gly Leu Lys Thr Leu Leu Ala Arg Gly Ala 
            260                 265                 270         


Ile Val Arg Cys Pro Met Ala Gly Ile Ser His Thr Ala Trp His Ser 
        275                 280                 285             


Asn Arg Thr Leu Tyr Glu Thr Cys Ile Glu Pro Trp Leu Ser 
    290                 295                 300         


<210>  3221
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  3221

Met Glu Glu Gly Gly Asp Phe Asp Asn Tyr Tyr Gly Ala Asp Asn Gln 
1               5                   10                  15      


Ser Glu Cys Glu Tyr Thr Asp Trp Lys Ser Ser Gly Ala Leu Ile Pro 
            20                  25                  30          


Ala Ile Tyr Met Leu Val Phe Leu Leu Gly Thr Thr Gly Asn Gly Leu 
        35                  40                  45              


Val Leu Trp Thr Val Phe Arg Ser Ser Arg Glu Lys Arg Arg Ser Ala 
    50                  55                  60                  


Asp Ile Phe Ile Ala Ser Leu Ala Val Ala Asp Leu Thr Phe Val Val 
65                  70                  75                  80  


Thr Leu Pro Leu Trp Ala Thr Tyr Thr Tyr Arg Asp Tyr Asp Trp Pro 
                85                  90                  95      


Phe Gly Thr Phe Phe Cys Lys Leu Ser Ser Tyr Leu Ile Phe Val Asn 
            100                 105                 110         


Met Tyr Ala Ser Val Phe Cys Leu Thr Gly Leu Ser Phe Asp Arg Tyr 
        115                 120                 125             


Leu Ala Ile Val Arg Pro Val Ala Asn Ala Arg Leu Arg Leu Arg Val 
    130                 135                 140                 


Ser Gly Ala Val Ala Thr Ala Val Leu Trp Val Leu Ala Ala Leu Leu 
145                 150                 155                 160 


Ala Met Pro Val Met Val Leu Arg Thr Thr Gly Asp Leu Glu Asn Thr 
                165                 170                 175     


Thr Lys Val Gln Cys Tyr Met Asp Tyr Ser Met Val Ala Thr Val Ser 
            180                 185                 190         


Ser Glu Trp Ala Trp Glu Val Gly Leu Gly Val Ser Ser Thr Thr Val 
        195                 200                 205             


Gly Phe Val Val Pro Phe Thr Ile Met Leu Thr Cys Tyr Phe Phe Ile 
    210                 215                 220                 


Ala Gln Thr Ile Ala Gly His Phe Arg Lys Glu Arg Ile Glu Gly Leu 
225                 230                 235                 240 


Arg Lys Arg Arg Arg Leu Leu Ser Ile Ile Val Val Leu Val Val Thr 
                245                 250                 255     


Phe Ala Leu Cys Trp Met Pro Tyr His Leu Val Lys Thr Leu Tyr Met 
            260                 265                 270         


Leu Gly Ser Leu Leu His Trp Pro Cys Asp Phe Asp Leu Phe Leu Met 
        275                 280                 285             


Asn Ile Phe Pro Tyr Cys Thr Cys Ile Ser Tyr Val Asn Ser Cys Leu 
    290                 295                 300                 


Asn Pro Phe Leu Tyr Ala Phe Phe Asp Pro Arg Phe Arg Gln Ala Cys 
305                 310                 315                 320 


Thr Ser Met Leu Cys Cys Gly Gln Ser Arg Cys Ala Gly Thr Ser His 
                325                 330                 335     


Ser Ser Ser Gly Glu Lys Ser Ala Ser Tyr Ser Ser Gly His Ser Gln 
            340                 345                 350         


Gly Pro Gly Pro Asn Met Gly Lys Gly Gly Glu Gln Met His Glu Lys 
        355                 360                 365             


Ser Ile Pro Tyr Ser Gln Glu Thr Leu Val Val Asp 
    370                 375                 380 


<210>  3222
<211>  650
<212>  PRT
<213>  Homo sapiens

<400>  3222

Met Gly Pro Ala Ser Pro Ala Ala Arg Gly Leu Ser Arg Arg Pro Gly 
1               5                   10                  15      


Gln Pro Pro Leu Pro Leu Leu Leu Pro Leu Leu Leu Leu Leu Leu Arg 
            20                  25                  30          


Ala Gln Pro Ala Ile Gly Ser Leu Ala Gly Gly Ser Pro Gly Ala Ala 
        35                  40                  45              


Glu Ala Pro Gly Ser Ala Gln Val Ala Gly Leu Cys Gly Arg Leu Thr 
    50                  55                  60                  


Leu His Arg Asp Leu Arg Thr Gly Arg Trp Glu Pro Asp Pro Gln Arg 
65                  70                  75                  80  


Ser Arg Arg Cys Leu Arg Asp Pro Gln Arg Val Leu Glu Tyr Cys Arg 
                85                  90                  95      


Gln Met Tyr Pro Glu Leu Gln Ile Ala Arg Val Glu Gln Ala Thr Gln 
            100                 105                 110         


Ala Ile Pro Met Glu Arg Trp Cys Gly Gly Ser Arg Ser Gly Ser Cys 
        115                 120                 125             


Ala His Pro His His Gln Val Val Pro Phe Arg Cys Leu Pro Gly Glu 
    130                 135                 140                 


Phe Val Ser Glu Ala Leu Leu Val Pro Glu Gly Cys Arg Phe Leu His 
145                 150                 155                 160 


Gln Glu Arg Met Asp Gln Cys Glu Ser Ser Thr Arg Arg His Gln Glu 
                165                 170                 175     


Ala Gln Glu Ala Cys Ser Ser Gln Gly Leu Ile Leu His Gly Ser Gly 
            180                 185                 190         


Met Leu Leu Pro Cys Gly Ser Asp Arg Phe Arg Gly Val Glu Tyr Val 
        195                 200                 205             


Cys Cys Pro Pro Pro Gly Thr Pro Asp Pro Ser Gly Thr Ala Val Gly 
    210                 215                 220                 


Asp Pro Ser Thr Arg Ser Trp Pro Pro Gly Ser Arg Val Glu Gly Ala 
225                 230                 235                 240 


Glu Asp Glu Glu Glu Glu Glu Ser Phe Pro Gln Pro Val Asp Asp Tyr 
                245                 250                 255     


Phe Val Glu Pro Pro Gln Ala Glu Glu Glu Glu Glu Thr Val Pro Pro 
            260                 265                 270         


Pro Ser Ser His Thr Leu Ala Val Val Gly Lys Val Thr Pro Thr Pro 
        275                 280                 285             


Arg Pro Thr Asp Gly Val Asp Ile Tyr Phe Gly Met Pro Gly Glu Ile 
    290                 295                 300                 


Ser Glu His Glu Gly Phe Leu Arg Ala Lys Met Asp Leu Glu Glu Arg 
305                 310                 315                 320 


Arg Met Arg Gln Ile Asn Glu Val Met Arg Glu Trp Ala Met Ala Asp 
                325                 330                 335     


Asn Gln Ser Lys Asn Leu Pro Lys Ala Asp Arg Gln Ala Leu Asn Glu 
            340                 345                 350         


His Phe Gln Ser Ile Leu Gln Thr Leu Glu Glu Gln Val Ser Gly Glu 
        355                 360                 365             


Arg Gln Arg Leu Val Glu Thr His Ala Thr Arg Val Ile Ala Leu Ile 
    370                 375                 380                 


Asn Asp Gln Arg Arg Ala Ala Leu Glu Gly Phe Leu Ala Ala Leu Gln 
385                 390                 395                 400 


Ala Asp Pro Pro Gln Ala Glu Arg Val Leu Leu Ala Leu Arg Arg Tyr 
                405                 410                 415     


Leu Arg Ala Glu Gln Lys Glu Gln Arg His Thr Leu Arg His Tyr Gln 
            420                 425                 430         


His Val Ala Ala Val Asp Pro Glu Lys Ala Gln Gln Met Arg Phe Gln 
        435                 440                 445             


Val His Thr His Leu Gln Val Ile Glu Glu Arg Val Asn Gln Ser Leu 
    450                 455                 460                 


Gly Leu Leu Asp Gln Asn Pro His Leu Ala Gln Glu Leu Arg Pro Gln 
465                 470                 475                 480 


Ile Gln Glu Leu Leu His Ser Glu His Leu Gly Pro Ser Glu Leu Glu 
                485                 490                 495     


Ala Pro Ala Pro Gly Gly Ser Ser Glu Asp Lys Gly Gly Leu Gln Pro 
            500                 505                 510         


Pro Asp Ser Lys Asp Asp Thr Pro Met Thr Leu Pro Lys Gly Ser Thr 
        515                 520                 525             


Glu Gln Asp Ala Ala Ser Pro Glu Lys Glu Lys Met Asn Pro Leu Glu 
    530                 535                 540                 


Gln Tyr Glu Arg Lys Val Asn Ala Ser Val Pro Arg Gly Phe Pro Phe 
545                 550                 555                 560 


His Ser Ser Glu Ile Gln Arg Asp Glu Leu Ala Pro Ala Gly Thr Gly 
                565                 570                 575     


Val Ser Arg Glu Ala Val Ser Gly Leu Leu Ile Met Gly Ala Gly Gly 
            580                 585                 590         


Gly Ser Leu Ile Val Leu Ser Met Leu Leu Leu Arg Arg Lys Lys Pro 
        595                 600                 605             


Tyr Gly Ala Ile Ser His Gly Val Val Glu Val Asp Pro Met Leu Thr 
    610                 615                 620                 


Leu Glu Glu Gln Gln Leu Arg Glu Leu Gln Arg His Gly Tyr Glu Asn 
625                 630                 635                 640 


Pro Thr Tyr Arg Phe Leu Glu Glu Arg Pro 
                645                 650 


<210>  3223
<211>  999
<212>  PRT
<213>  Homo sapiens

<400>  3223

Met Glu Ala Ala His Leu Leu Pro Ala Ala Asp Val Leu Arg His Phe 
1               5                   10                  15      


Ser Val Thr Ala Glu Gly Gly Leu Ser Pro Ala Gln Val Thr Gly Ala 
            20                  25                  30          


Arg Glu Arg Tyr Gly Pro Asn Glu Leu Pro Ser Glu Glu Gly Lys Ser 
        35                  40                  45              


Leu Trp Glu Leu Val Leu Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Leu Val Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Thr Thr Ala Phe Val Glu Pro Leu Val Ile Met Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Ser Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Ile Arg Ser Asp Arg Lys Gly Val Gln Arg Ile Arg Ala Arg Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Leu Arg Leu Ile Glu Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Thr Lys His Thr Glu 
            180                 185                 190         


Ala Ile Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Thr Ser Gly Lys Ala Val Gly Val Ala Val 
    210                 215                 220                 


Ala Thr Gly Leu His Thr Glu Leu Gly Lys Ile Arg Ser Gln Met Ala 
225                 230                 235                 240 


Ala Val Glu Pro Glu Arg Thr Pro Leu Gln Arg Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Arg Gln Leu Ser His Ala Ile Ser Val Ile Cys Val Ala Val Trp 
            260                 265                 270         


Val Ile Asn Ile Gly His Phe Ala Asp Pro Ala His Gly Gly Ser Trp 
        275                 280                 285             


Leu Arg Gly Ala Val Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Arg Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Val 
        355                 360                 365             


Val Ala Glu Ala Asp Ala Gly Ser Cys Leu Leu His Glu Phe Thr Ile 
    370                 375                 380                 


Ser Gly Thr Thr Tyr Thr Pro Glu Gly Glu Val Arg Gln Gly Asp Gln 
385                 390                 395                 400 


Pro Val Arg Cys Gly Gln Phe Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Asp Leu Gln Ala Leu Ser Arg 
    450                 455                 460                 


Val Glu Arg Ala Gly Ala Cys Asn Thr Val Ile Lys Gln Leu Met Arg 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Thr Arg Pro His Pro Thr Gly Gln Gly Ser Lys Met 
            500                 505                 510         


Phe Val Lys Gly Ala Pro Glu Ser Val Ile Glu Arg Cys Ser Ser Val 
        515                 520                 525             


Arg Val Gly Ser Arg Thr Ala Pro Leu Thr Pro Thr Ser Arg Glu Gln 
    530                 535                 540                 


Ile Leu Ala Lys Ile Arg Asp Trp Gly Ser Gly Ser Asp Thr Leu Arg 
545                 550                 555                 560 


Cys Leu Ala Leu Ala Thr Arg Asp Ala Pro Pro Arg Lys Glu Asp Met 
                565                 570                 575     


Glu Leu Asp Asp Cys Ser Lys Phe Val Gln Tyr Glu Thr Asp Leu Thr 
            580                 585                 590         


Phe Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Pro Glu Val Ala 
        595                 600                 605             


Ala Cys Ile Thr Arg Cys Tyr Gln Ala Gly Ile Arg Val Val Met Ile 
    610                 615                 620                 


Thr Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Leu Gly 
625                 630                 635                 640 


Ile Phe Gly Asp Thr Glu Asp Val Ala Gly Lys Ala Tyr Thr Gly Arg 
                645                 650                 655     


Glu Phe Asp Asp Leu Ser Pro Glu Gln Gln Arg Gln Ala Cys Arg Thr 
            660                 665                 670         


Ala Arg Cys Phe Ala Arg Val Glu Pro Ala His Lys Ser Arg Ile Val 
        675                 680                 685             


Glu Asn Leu Gln Ser Phe Asn Glu Ile Thr Ala Met Thr Gly Asp Gly 
    690                 695                 700                 


Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met 
705                 710                 715                 720 


Gly Ser Gly Thr Ala Val Ala Lys Ser Ala Ala Glu Met Val Leu Ser 
                725                 730                 735     


Asp Asp Asn Phe Ala Ser Ile Val Ala Ala Val Glu Glu Gly Arg Ala 
            740                 745                 750         


Ile Tyr Ser Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn 
        755                 760                 765             


Val Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ile Leu Gly Leu Pro 
    770                 775                 780                 


Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp 
785                 790                 795                 800 


Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile 
                805                 810                 815     


Met Glu Lys Leu Pro Arg Ser Pro Arg Glu Ala Leu Ile Ser Gly Trp 
            820                 825                 830         


Leu Phe Phe Arg Tyr Leu Ala Ile Gly Val Tyr Val Gly Leu Ala Thr 
        835                 840                 845             


Val Ala Ala Ala Thr Trp Trp Phe Val Tyr Asp Ala Glu Gly Pro His 
    850                 855                 860                 


Ile Asn Phe Tyr Gln Leu Arg Asn Phe Leu Lys Cys Ser Glu Asp Asn 
865                 870                 875                 880 


Pro Leu Phe Ala Gly Ile Asp Cys Glu Val Phe Glu Ser Arg Phe Pro 
                885                 890                 895     


Thr Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala 
            900                 905                 910         


Leu Asn Ser Val Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp 
        915                 920                 925             


Met Asn Pro Trp Leu Leu Val Ala Val Ala Met Ser Met Ala Leu His 
    930                 935                 940                 


Phe Leu Ile Leu Leu Val Pro Pro Leu Pro Leu Ile Phe Gln Val Thr 
945                 950                 955                 960 


Pro Leu Ser Gly Arg Gln Trp Val Val Val Leu Gln Ile Ser Leu Pro 
                965                 970                 975     


Val Ile Leu Leu Asp Glu Ala Leu Lys Tyr Leu Ser Arg Asn His Met 
            980                 985                 990         


His Glu Glu Met Ser Gln Lys 
        995                 


<210>  3224
<211>  1977
<212>  PRT
<213>  Homo sapiens

<400>  3224

Met Ser Glu Ser Glu Gly Gly Lys Asp Thr Thr Pro Glu Pro Ser Pro 
1               5                   10                  15      


Ala Asn Gly Ala Gly Pro Gly Pro Glu Trp Gly Leu Cys Pro Gly Pro 
            20                  25                  30          


Pro Ala Val Glu Gly Glu Ser Ser Gly Ala Ser Gly Leu Gly Thr Pro 
        35                  40                  45              


Lys Arg Arg Asn Gln His Ser Lys His Lys Thr Val Ala Val Ala Ser 
    50                  55                  60                  


Ala Gln Arg Ser Pro Arg Ala Leu Phe Cys Leu Thr Leu Ala Asn Pro 
65                  70                  75                  80  


Leu Arg Arg Ser Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Asp Ile 
                85                  90                  95      


Leu Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Gly Val Tyr 
            100                 105                 110         


Ile Pro Phe Pro Glu Asp Asp Ser Asn Thr Ala Asn His Asn Leu Glu 
        115                 120                 125             


Gln Val Glu Tyr Val Phe Leu Val Ile Phe Thr Val Glu Thr Val Leu 
    130                 135                 140                 


Lys Ile Val Ala Tyr Gly Leu Val Leu His Pro Ser Ala Tyr Ile Arg 
145                 150                 155                 160 


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
                165                 170                 175     


Ser Val Leu Leu Glu Gln Gly Pro Gly Arg Pro Gly Asp Ala Pro His 
            180                 185                 190         


Thr Gly Gly Lys Pro Gly Gly Phe Asp Val Lys Ala Leu Arg Ala Phe 
        195                 200                 205             


Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu His 
    210                 215                 220                 


Ile Val Leu Asn Ser Ile Met Lys Ala Leu Val Pro Leu Leu His Ile 
225                 230                 235                 240 


Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu 
                245                 250                 255     


Glu Leu Phe Leu Gly Arg Met His Lys Thr Cys Tyr Phe Leu Gly Ser 
            260                 265                 270         


Asp Met Glu Ala Glu Glu Asp Pro Ser Pro Cys Ala Ser Ser Gly Ser 
        275                 280                 285             


Gly Arg Ala Cys Thr Leu Asn Gln Thr Glu Cys Arg Gly Arg Trp Pro 
    290                 295                 300                 


Gly Pro Asn Gly Gly Ile Thr Asn Phe Asp Asn Phe Phe Phe Ala Met 
305                 310                 315                 320 


Leu Thr Val Phe Gln Cys Val Thr Met Glu Gly Trp Thr Asp Val Leu 
                325                 330                 335     


Tyr Trp Met Gln Asp Ala Met Gly Tyr Glu Leu Pro Trp Val Tyr Phe 
            340                 345                 350         


Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu Val Leu 
        355                 360                 365             


Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys Ala 
    370                 375                 380                 


Arg Gly Asp Phe Gln Lys Gln Arg Glu Lys Gln Gln Met Glu Glu Asp 
385                 390                 395                 400 


Leu Arg Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Glu Leu Asp Met 
                405                 410                 415     


Glu Asp Pro Ser Ala Asp Asp Asn Leu Gly Ser Met Ala Glu Glu Gly 
            420                 425                 430         


Arg Ala Gly His Arg Pro Gln Leu Ala Glu Leu Thr Asn Arg Arg Arg 
        435                 440                 445             


Gly Arg Leu Arg Trp Phe Ser His Ser Thr Arg Ser Thr His Ser Thr 
    450                 455                 460                 


Ser Ser His Ala Ser Leu Pro Ala Ser Asp Thr Gly Ser Met Thr Glu 
465                 470                 475                 480 


Thr Gln Gly Asp Glu Asp Glu Glu Glu Gly Ala Leu Ala Ser Cys Thr 
                485                 490                 495     


Arg Cys Leu Asn Lys Ile Met Lys Thr Arg Val Cys Arg Arg Leu Arg 
            500                 505                 510         


Arg Ala Asn Arg Val Leu Arg Ala Arg Cys Arg Arg Ala Val Lys Ser 
        515                 520                 525             


Asn Ala Cys Tyr Trp Ala Val Leu Leu Leu Val Phe Leu Asn Thr Leu 
    530                 535                 540                 


Thr Ile Ala Ser Glu His His Gly Gln Pro Val Trp Leu Thr Gln Ile 
545                 550                 555                 560 


Gln Glu Tyr Ala Asn Lys Val Leu Leu Cys Leu Phe Thr Val Glu Met 
                565                 570                 575     


Leu Leu Lys Leu Tyr Gly Leu Gly Pro Ser Ala Tyr Val Ser Ser Phe 
            580                 585                 590         


Phe Asn Arg Phe Asp Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr 
        595                 600                 605             


Thr Leu Val Glu Val Gly Ala Met Gln Pro Leu Gly Ile Ser Val Leu 
    610                 615                 620                 


Arg Cys Val Arg Leu Leu Arg Ile Phe Lys Val Thr Arg His Trp Ala 
625                 630                 635                 640 


Ser Leu Ser Asn Leu Val Ala Ser Leu Leu Asn Ser Met Lys Ser Ile 
                645                 650                 655     


Ala Ser Leu Leu Leu Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu 
            660                 665                 670         


Leu Gly Met Gln Leu Phe Gly Gly Lys Phe Asn Phe Asp Gln Thr His 
        675                 680                 685             


Thr Lys Arg Ser Thr Phe Asp Thr Phe Pro Gln Ala Leu Leu Thr Val 
    690                 695                 700                 


Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Val Val Met Tyr Asp Gly 
705                 710                 715                 720 


Ile Met Ala Tyr Gly Gly Pro Phe Phe Pro Gly Met Leu Val Cys Ile 
                725                 730                 735     


Tyr Phe Ile Ile Leu Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val 
            740                 745                 750         


Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Ser Gly Asp Ala Gly Thr 
        755                 760                 765             


Ala Lys Asp Lys Gly Gly Glu Lys Ser Asn Glu Lys Asp Leu Pro Gln 
    770                 775                 780                 


Glu Asn Glu Gly Leu Val Pro Gly Val Glu Lys Glu Glu Glu Glu Gly 
785                 790                 795                 800 


Ala Arg Arg Glu Gly Ala Asp Met Glu Glu Glu Glu Glu Glu Glu Glu 
                805                 810                 815     


Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ala Gly Gly Val Glu Leu 
            820                 825                 830         


Leu Gln Glu Val Val Pro Lys Glu Lys Val Val Pro Ile Pro Glu Gly 
        835                 840                 845             


Ser Ala Phe Phe Cys Leu Ser Gln Thr Asn Pro Leu Arg Lys Gly Cys 
    850                 855                 860                 


His Thr Leu Ile His His His Val Phe Thr Asn Leu Ile Leu Val Phe 
865                 870                 875                 880 


Ile Ile Leu Ser Ser Val Ser Leu Ala Ala Glu Asp Pro Ile Arg Ala 
                885                 890                 895     


His Ser Phe Arg Asn His Ile Leu Gly Tyr Phe Asp Tyr Ala Phe Thr 
            900                 905                 910         


Ser Ile Phe Thr Val Glu Ile Leu Leu Lys Met Thr Val Phe Gly Ala 
        915                 920                 925             


Phe Leu His Arg Gly Ser Phe Cys Arg Ser Trp Phe Asn Met Leu Asp 
    930                 935                 940                 


Leu Leu Val Val Ser Val Ser Leu Ile Ser Phe Gly Ile His Ser Ser 
945                 950                 955                 960 


Ala Ile Ser Val Val Lys Ile Leu Arg Val Leu Arg Val Leu Arg Pro 
                965                 970                 975     


Leu Arg Ala Ile Asn Arg Ala Lys Gly Leu Lys His Val Val Gln Cys 
            980                 985                 990         


Val Phe Val Ala Ile Arg Thr Ile  Gly Asn Ile Met Ile  Val Thr Thr 
        995                 1000                 1005             


Leu Leu  Gln Phe Met Phe Ala  Cys Ile Gly Val Gln  Leu Phe Lys 
    1010                 1015                 1020             


Gly Lys  Phe Tyr Thr Cys Thr  Asp Glu Ala Lys His  Thr Pro Gln 
    1025                 1030                 1035             


Glu Cys  Lys Gly Ser Phe Leu  Val Tyr Pro Asp Gly  Asp Val Ser 
    1040                 1045                 1050             


Arg Pro  Leu Val Arg Glu Arg  Leu Trp Val Asn Ser  Asp Phe Asn 
    1055                 1060                 1065             


Phe Asp  Asn Val Leu Ser Ala  Met Met Ala Leu Phe  Thr Val Ser 
    1070                 1075                 1080             


Thr Phe  Glu Gly Trp Pro Ala  Leu Leu Tyr Lys Ala  Ile Asp Ala 
    1085                 1090                 1095             


Tyr Ala  Glu Asp His Gly Pro  Ile Tyr Asn Tyr Arg  Val Glu Ile 
    1100                 1105                 1110             


Ser Val  Phe Phe Ile Val Tyr  Ile Ile Ile Ile Ala  Phe Phe Met 
    1115                 1120                 1125             


Met Asn  Ile Phe Val Gly Phe  Val Ile Ile Thr Phe  Arg Ala Gln 
    1130                 1135                 1140             


Gly Glu  Gln Glu Tyr Gln Asn  Cys Glu Leu Asp Lys  Asn Gln Arg 
    1145                 1150                 1155             


Gln Cys  Val Glu Tyr Ala Leu  Lys Ala Gln Pro Leu  Arg Arg Tyr 
    1160                 1165                 1170             


Ile Pro  Lys Asn Pro His Gln  Tyr Arg Val Trp Ala  Thr Val Asn 
    1175                 1180                 1185             


Ser Ala  Ala Phe Glu Tyr Leu  Met Phe Leu Leu Ile  Leu Leu Asn 
    1190                 1195                 1200             


Thr Val  Ala Leu Ala Met Gln  His Tyr Glu Gln Thr  Ala Pro Phe 
    1205                 1210                 1215             


Asn Tyr  Ala Met Asp Ile Leu  Asn Met Val Phe Thr  Gly Leu Phe 
    1220                 1225                 1230             


Thr Ile  Glu Met Val Leu Lys  Ile Ile Ala Phe Lys  Pro Lys His 
    1235                 1240                 1245             


Tyr Phe  Thr Asp Ala Trp Asn  Thr Phe Asp Ala Leu  Ile Val Val 
    1250                 1255                 1260             


Gly Ser  Ile Val Asp Ile Ala  Val Thr Glu Val Asn  Asn Gly Gly 
    1265                 1270                 1275             


His Leu  Gly Glu Ser Ser Glu  Asp Ser Ser Arg Ile  Ser Ile Thr 
    1280                 1285                 1290             


Phe Phe  Arg Leu Phe Arg Val  Met Arg Leu Val Lys  Leu Leu Ser 
    1295                 1300                 1305             


Lys Gly  Glu Gly Ile Arg Thr  Leu Leu Trp Thr Phe  Ile Lys Ser 
    1310                 1315                 1320             


Phe Gln  Ala Leu Pro Tyr Val  Ala Leu Leu Ile Ala  Met Ile Phe 
    1325                 1330                 1335             


Phe Ile  Tyr Ala Val Ile Gly  Met Gln Met Phe Gly  Lys Val Ala 
    1340                 1345                 1350             


Leu Gln  Asp Gly Thr Gln Ile  Asn Arg Asn Asn Asn  Phe Gln Thr 
    1355                 1360                 1365             


Phe Pro  Gln Ala Val Leu Leu  Leu Phe Arg Cys Ala  Thr Gly Glu 
    1370                 1375                 1380             


Ala Trp  Gln Glu Ile Met Leu  Ala Ser Leu Pro Gly  Asn Arg Cys 
    1385                 1390                 1395             


Asp Pro  Glu Ser Asp Phe Gly  Pro Gly Glu Glu Phe  Thr Cys Gly 
    1400                 1405                 1410             


Ser Asn  Phe Ala Ile Ala Tyr  Phe Ile Ser Phe Phe  Met Leu Cys 
    1415                 1420                 1425             


Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala Val Ile  Met Asp Asn 
    1430                 1435                 1440             


Phe Asp  Tyr Leu Thr Arg Asp  Trp Ser Ile Leu Gly  Pro His His 
    1445                 1450                 1455             


Leu Asp  Glu Phe Lys Arg Ile  Trp Ser Glu Tyr Asp  Pro Gly Ala 
    1460                 1465                 1470             


Lys Gly  Arg Ile Lys His Leu  Asp Val Val Ala Leu  Leu Arg Arg 
    1475                 1480                 1485             


Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu Cys Pro  His Arg Val 
    1490                 1495                 1500             


Ala Cys  Lys Arg Leu Val Ala  Met Asn Met Pro Leu  Asn Ser Asp 
    1505                 1510                 1515             


Gly Thr  Val Thr Phe Asn Ala  Thr Leu Phe Ala Leu  Val Arg Thr 
    1520                 1525                 1530             


Ser Leu  Lys Ile Lys Thr Glu  Gly Asn Leu Glu Gln  Ala Asn Gln 
    1535                 1540                 1545             


Glu Leu  Arg Ile Val Ile Lys  Lys Ile Trp Lys Arg  Met Lys Gln 
    1550                 1555                 1560             


Lys Leu  Leu Asp Glu Val Ile  Pro Pro Pro Asp Glu  Glu Glu Val 
    1565                 1570                 1575             


Thr Val  Gly Lys Phe Tyr Ala  Thr Phe Leu Ile Gln  Asp Tyr Phe 
    1580                 1585                 1590             


Arg Lys  Phe Arg Arg Arg Lys  Glu Lys Gly Leu Leu  Gly Asn Asp 
    1595                 1600                 1605             


Ala Ala  Pro Ser Thr Ser Ser  Ala Leu Gln Ala Gly  Leu Arg Ser 
    1610                 1615                 1620             


Leu Gln  Asp Leu Gly Pro Glu  Met Arg Gln Ala Leu  Thr Cys Asp 
    1625                 1630                 1635             


Thr Glu  Glu Glu Glu Glu Glu  Gly Gln Glu Gly Val  Glu Glu Glu 
    1640                 1645                 1650             


Asp Glu  Lys Asp Leu Glu Thr  Asn Lys Ala Thr Met  Val Ser Gln 
    1655                 1660                 1665             


Pro Ser  Ala Arg Arg Gly Ser  Gly Ile Ser Val Ser  Leu Pro Val 
    1670                 1675                 1680             


Gly Asp  Arg Leu Pro Asp Ser  Leu Ser Phe Gly Pro  Ser Asp Asp 
    1685                 1690                 1695             


Asp Arg  Gly Thr Pro Thr Ser  Ser Gln Pro Ser Val  Pro Gln Ala 
    1700                 1705                 1710             


Gly Ser  Asn Thr His Arg Arg  Gly Ser Gly Ala Leu  Ile Phe Thr 
    1715                 1720                 1725             


Ile Pro  Glu Glu Gly Asn Ser  Gln Pro Lys Gly Thr  Lys Gly Gln 
    1730                 1735                 1740             


Asn Lys  Gln Asp Glu Asp Glu  Glu Val Pro Asp Arg  Leu Ser Tyr 
    1745                 1750                 1755             


Leu Asp  Glu Gln Ala Gly Thr  Pro Pro Cys Ser Val  Leu Leu Pro 
    1760                 1765                 1770             


Pro His  Arg Ala Gln Arg Tyr  Met Asp Gly His Leu  Val Pro Arg 
    1775                 1780                 1785             


Arg Arg  Leu Leu Pro Pro Thr  Pro Ala Gly Arg Lys  Pro Ser Phe 
    1790                 1795                 1800             


Thr Ile  Gln Cys Leu Gln Arg  Gln Gly Ser Cys Glu  Asp Leu Pro 
    1805                 1810                 1815             


Ile Pro  Gly Thr Tyr His Arg  Gly Arg Asn Ser Gly  Pro Asn Arg 
    1820                 1825                 1830             


Ala Gln  Gly Ser Trp Ala Thr  Pro Pro Gln Arg Gly  Arg Leu Leu 
    1835                 1840                 1845             


Tyr Ala  Pro Leu Leu Leu Val  Glu Glu Gly Ala Ala  Gly Glu Gly 
    1850                 1855                 1860             


Tyr Leu  Gly Arg Ser Ser Gly  Pro Leu Arg Thr Phe  Thr Cys Leu 
    1865                 1870                 1875             


His Val  Pro Gly Thr His Ser  Asp Pro Ser His Gly  Lys Arg Gly 
    1880                 1885                 1890             


Ser Ala  Asp Ser Leu Val Glu  Ala Val Leu Ile Ser  Glu Gly Leu 
    1895                 1900                 1905             


Gly Leu  Phe Ala Arg Asp Pro  Arg Phe Val Ala Leu  Ala Lys Gln 
    1910                 1915                 1920             


Glu Ile  Ala Asp Ala Cys Arg  Leu Thr Leu Asp Glu  Met Asp Asn 
    1925                 1930                 1935             


Ala Ala  Ser Asp Leu Leu Ala  Gln Gly Thr Ser Ser  Leu Tyr Ser 
    1940                 1945                 1950             


Asp Glu  Glu Ser Ile Leu Ser  Arg Phe Asp Glu Glu  Asp Leu Gly 
    1955                 1960                 1965             


Asp Glu  Met Ala Cys Val His  Ala Leu 
    1970                 1975         


<210>  3225
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  3225

Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro 
225                 230                 235                 240 


Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly 
                245                 250                 255     


Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg 
            260                 265                 270         


Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val 
        275                 280                 285             


<210>  3226
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  3226

Met Lys Pro Pro Ser Ser Ile Gln Thr Ser Glu Phe Asp Ser Ser Asp 
1               5                   10                  15      


Glu Glu Pro Ile Glu Asp Glu Gln Thr Pro Ile His Ile Ser Trp Leu 
            20                  25                  30          


Ser Leu Ser Arg Val Asn Cys Ser Gln Phe Leu Gly Leu Cys Ala Leu 
        35                  40                  45              


Pro Gly Cys Lys Phe Lys Asp Val Arg Arg Asn Val Gln Lys Asp Thr 
    50                  55                  60                  


Glu Glu Leu Lys Ser Cys Gly Ile Gln Asp Ile Phe Val Phe Cys Thr 
65                  70                  75                  80  


Arg Gly Glu Leu Ser Lys Tyr Arg Val Pro Asn Leu Leu Asp Leu Tyr 
                85                  90                  95      


Gln Gln Cys Gly Ile Ile Thr His His His Pro Ile Ala Asp Gly Gly 
            100                 105                 110         


Thr Pro Asp Ile Ala Ser Cys Cys Glu Ile Met Glu Glu Leu Thr Thr 
        115                 120                 125             


Cys Leu Lys Asn Tyr Arg Lys Thr Leu Ile His Cys Tyr Gly Gly Leu 
    130                 135                 140                 


Gly Arg Ser Cys Leu Val Ala Ala Cys Leu Leu Leu Tyr Leu Ser Asp 
145                 150                 155                 160 


Thr Ile Ser Pro Glu Gln Ala Ile Asp Ser Leu Arg Asp Leu Arg Gly 
                165                 170                 175     


Ser Gly Ala Ile Gln Thr Ile Lys Gln Tyr Asn Tyr Leu His Glu Phe 
            180                 185                 190         


Arg Asp Lys Leu Ala Ala His Leu Ser Ser Arg Asp Ser Gln Ser Arg 
        195                 200                 205             


Ser Val Ser Arg 
    210         


<210>  3227
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  3227

Met His Gly Gly Gln Gly Pro Leu Leu Leu Leu Leu Leu Leu Ala Val 
1               5                   10                  15      


Cys Leu Gly Ala Gln Gly Arg Asn Gln Glu Glu Arg Leu Leu Ala Asp 
            20                  25                  30          


Leu Met Gln Asn Tyr Asp Pro Asn Leu Arg Pro Ala Glu Arg Asp Ser 
        35                  40                  45              


Asp Val Val Asn Val Ser Leu Lys Leu Thr Leu Thr Asn Leu Ile Ser 
    50                  55                  60                  


Leu Asn Glu Arg Glu Glu Ala Leu Thr Thr Asn Val Trp Ile Glu Met 
65                  70                  75                  80  


Gln Trp Cys Asp Tyr Arg Leu Arg Trp Asp Pro Arg Asp Tyr Glu Gly 
                85                  90                  95      


Leu Trp Val Leu Arg Val Pro Ser Thr Met Val Trp Arg Pro Asp Ile 
            100                 105                 110         


Val Leu Glu Asn Asn Val Asp Gly Val Phe Glu Val Ala Leu Tyr Cys 
        115                 120                 125             


Asn Val Leu Val Ser Pro Asp Gly Cys Ile Tyr Trp Leu Pro Pro Ala 
    130                 135                 140                 


Ile Phe Arg Ser Ala Cys Ser Ile Ser Val Thr Tyr Phe Pro Phe Asp 
145                 150                 155                 160 


Trp Gln Asn Cys Ser Leu Ile Phe Gln Ser Gln Thr Tyr Ser Thr Asn 
                165                 170                 175     


Glu Ile Asp Leu Gln Leu Ser Gln Glu Asp Gly Gln Thr Ile Glu Trp 
            180                 185                 190         


Ile Phe Ile Asp Pro Glu Ala Phe Thr Glu Asn Gly Glu Trp Ala Ile 
        195                 200                 205             


Gln His Arg Pro Ala Lys Met Leu Leu Asp Pro Ala Ala Pro Ala Gln 
    210                 215                 220                 


Glu Ala Gly His Gln Lys Val Val Phe Tyr Leu Leu Ile Gln Arg Lys 
225                 230                 235                 240 


Pro Leu Phe Tyr Val Ile Asn Ile Ile Ala Pro Cys Val Leu Ile Ser 
                245                 250                 255     


Ser Val Ala Ile Leu Ile His Phe Leu Pro Ala Lys Ala Gly Gly Gln 
            260                 265                 270         


Lys Cys Thr Val Ala Ile Asn Val Leu Leu Ala Gln Thr Val Phe Leu 
        275                 280                 285             


Phe Leu Val Ala Lys Lys Val Pro Glu Thr Ser Gln Ala Val Pro Leu 
    290                 295                 300                 


Ile Ser Lys Tyr Leu Thr Phe Leu Leu Val Val Thr Ile Leu Ile Val 
305                 310                 315                 320 


Val Asn Ala Val Val Val Leu Asn Val Ser Leu Arg Ser Pro His Thr 
                325                 330                 335     


His Ser Met Ala Arg Gly Val Arg Lys Val Phe Leu Arg Leu Leu Pro 
            340                 345                 350         


Gln Leu Leu Arg Met His Val Arg Pro Leu Ala Pro Ala Ala Val Gln 
        355                 360                 365             


Asp Thr Gln Ser Arg Leu Gln Asn Gly Ser Ser Gly Trp Ser Ile Thr 
    370                 375                 380                 


Thr Gly Glu Glu Val Ala Leu Cys Leu Pro Arg Ser Glu Leu Leu Phe 
385                 390                 395                 400 


Gln Gln Trp Gln Arg Gln Gly Leu Val Ala Ala Ala Leu Glu Lys Leu 
                405                 410                 415     


Glu Lys Gly Pro Glu Leu Gly Leu Ser Gln Phe Cys Gly Ser Leu Lys 
            420                 425                 430         


Gln Ala Ala Pro Ala Ile Gln Ala Cys Val Glu Ala Cys Asn Leu Ile 
        435                 440                 445             


Ala Cys Ala Arg His Gln Gln Ser His Phe Asp Asn Gly Asn Glu Glu 
    450                 455                 460                 


Trp Phe Leu Val Gly Arg Val Leu Asp Arg Val Cys Phe Leu Ala Met 
465                 470                 475                 480 


Leu Ser Leu Phe Ile Cys Gly Thr Ala Gly Ile Phe Leu Met Ala His 
                485                 490                 495     


Tyr Asn Arg Val Pro Ala Leu Pro Phe Pro Gly Asp Pro Arg Pro Tyr 
            500                 505                 510         


Leu Pro Ser Pro Asp 
        515         


<210>  3228
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  3228

Met Asp Tyr Thr Leu Asp Leu Ser Val Thr Thr Val Thr Asp Tyr Tyr 
1               5                   10                  15      


Tyr Pro Asp Ile Phe Ser Ser Pro Cys Asp Ala Glu Leu Ile Gln Thr 
            20                  25                  30          


Asn Gly Lys Leu Leu Leu Ala Val Phe Tyr Cys Leu Leu Phe Val Phe 
        35                  40                  45              


Ser Leu Leu Gly Asn Ser Leu Val Ile Leu Val Leu Val Val Cys Lys 
    50                  55                  60                  


Lys Leu Arg Ser Ile Thr Asp Val Tyr Leu Leu Asn Leu Ala Leu Ser 
65                  70                  75                  80  


Asp Leu Leu Phe Val Phe Ser Phe Pro Phe Gln Thr Tyr Tyr Leu Leu 
                85                  90                  95      


Asp Gln Trp Val Phe Gly Thr Val Met Cys Lys Val Val Ser Gly Phe 
            100                 105                 110         


Tyr Tyr Ile Gly Phe Tyr Ser Ser Met Phe Phe Ile Thr Leu Met Ser 
        115                 120                 125             


Val Asp Arg Tyr Leu Ala Val Val His Ala Val Tyr Ala Leu Lys Val 
    130                 135                 140                 


Arg Thr Ile Arg Met Gly Thr Thr Leu Cys Leu Ala Val Trp Leu Thr 
145                 150                 155                 160 


Ala Ile Met Ala Thr Ile Pro Leu Leu Val Phe Tyr Gln Val Ala Ser 
                165                 170                 175     


Glu Asp Gly Val Leu Gln Cys Tyr Ser Phe Tyr Asn Gln Gln Thr Leu 
            180                 185                 190         


Lys Trp Lys Ile Phe Thr Asn Phe Lys Met Asn Ile Leu Gly Leu Leu 
        195                 200                 205             


Ile Pro Phe Thr Ile Phe Met Phe Cys Tyr Ile Lys Ile Leu His Gln 
    210                 215                 220                 


Leu Lys Arg Cys Gln Asn His Asn Lys Thr Lys Ala Ile Arg Leu Val 
225                 230                 235                 240 


Leu Ile Val Val Ile Ala Ser Leu Leu Phe Trp Val Pro Phe Asn Val 
                245                 250                 255     


Val Leu Phe Leu Thr Ser Leu His Ser Met His Ile Leu Asp Gly Cys 
            260                 265                 270         


Ser Ile Ser Gln Gln Leu Thr Tyr Ala Thr His Val Thr Glu Ile Ile 
        275                 280                 285             


Ser Phe Thr His Cys Cys Val Asn Pro Val Ile Tyr Ala Phe Val Gly 
    290                 295                 300                 


Glu Lys Phe Lys Lys His Leu Ser Glu Ile Phe Gln Lys Ser Cys Ser 
305                 310                 315                 320 


Gln Ile Phe Asn Tyr Leu Gly Arg Gln Met Pro Arg Glu Ser Cys Glu 
                325                 330                 335     


Lys Ser Ser Ser Cys Gln Gln His Ser Ser Arg Ser Ser Ser Val Asp 
            340                 345                 350         


Tyr Ile Leu 
        355 


<210>  3229
<211>  972
<212>  PRT
<213>  Homo sapiens

<400>  3229

Met Gly Pro Gly Val Leu Leu Leu Leu Leu Val Ala Thr Ala Trp His 
1               5                   10                  15      


Gly Gln Gly Ile Pro Val Ile Glu Pro Ser Val Pro Glu Leu Val Val 
            20                  25                  30          


Lys Pro Gly Ala Thr Val Thr Leu Arg Cys Val Gly Asn Gly Ser Val 
        35                  40                  45              


Glu Trp Asp Gly Pro Pro Ser Pro His Trp Thr Leu Tyr Ser Asp Gly 
    50                  55                  60                  


Ser Ser Ser Ile Leu Ser Thr Asn Asn Ala Thr Phe Gln Asn Thr Gly 
65                  70                  75                  80  


Thr Tyr Arg Cys Thr Glu Pro Gly Asp Pro Leu Gly Gly Ser Ala Ala 
                85                  90                  95      


Ile His Leu Tyr Val Lys Asp Pro Ala Arg Pro Trp Asn Val Leu Ala 
            100                 105                 110         


Gln Glu Val Val Val Phe Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu 
        115                 120                 125             


Leu Thr Asp Pro Val Leu Glu Ala Gly Val Ser Leu Val Arg Val Arg 
    130                 135                 140                 


Gly Arg Pro Leu Met Arg His Thr Asn Tyr Ser Phe Ser Pro Trp His 
145                 150                 155                 160 


Gly Phe Thr Ile His Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln 
                165                 170                 175     


Cys Ser Ala Leu Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg 
            180                 185                 190         


Leu Lys Val Gln Lys Val Ile Pro Gly Pro Pro Ala Leu Thr Leu Val 
        195                 200                 205             


Pro Ala Glu Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys 
    210                 215                 220                 


Ser Ala Ser Ser Val Asp Val Asn Phe Asp Val Phe Leu Gln His Asn 
225                 230                 235                 240 


Asn Thr Lys Leu Ala Ile Pro Gln Gln Ser Asp Phe His Asn Asn Arg 
                245                 250                 255     


Tyr Gln Lys Val Leu Thr Leu Asn Leu Asp Gln Val Asp Phe Gln His 
            260                 265                 270         


Ala Gly Asn Tyr Ser Cys Val Ala Ser Asn Val Gln Gly Lys His Ser 
        275                 280                 285             


Thr Ser Met Phe Phe Arg Val Val Glu Ser Ala Tyr Leu Asn Leu Ser 
    290                 295                 300                 


Ser Glu Gln Asn Leu Ile Gln Glu Val Thr Val Gly Glu Gly Leu Asn 
305                 310                 315                 320 


Leu Lys Val Met Val Glu Ala Tyr Pro Gly Leu Gln Gly Phe Asn Trp 
                325                 330                 335     


Thr Tyr Leu Gly Pro Phe Ser Asp His Gln Pro Glu Pro Lys Leu Ala 
            340                 345                 350         


Asn Ala Thr Thr Lys Asp Thr Tyr Arg His Thr Phe Thr Leu Ser Leu 
        355                 360                 365             


Pro Arg Leu Lys Pro Ser Glu Ala Gly Arg Tyr Ser Phe Leu Ala Arg 
    370                 375                 380                 


Asn Pro Gly Gly Trp Arg Ala Leu Thr Phe Glu Leu Thr Leu Arg Tyr 
385                 390                 395                 400 


Pro Pro Glu Val Ser Val Ile Trp Thr Phe Ile Asn Gly Ser Gly Thr 
                405                 410                 415     


Leu Leu Cys Ala Ala Ser Gly Tyr Pro Gln Pro Asn Val Thr Trp Leu 
            420                 425                 430         


Gln Cys Ser Gly His Thr Asp Arg Cys Asp Glu Ala Gln Val Leu Gln 
        435                 440                 445             


Val Trp Asp Asp Pro Tyr Pro Glu Val Leu Ser Gln Glu Pro Phe His 
    450                 455                 460                 


Lys Val Thr Val Gln Ser Leu Leu Thr Val Glu Thr Leu Glu His Asn 
465                 470                 475                 480 


Gln Thr Tyr Glu Cys Arg Ala His Asn Ser Val Gly Ser Gly Ser Trp 
                485                 490                 495     


Ala Phe Ile Pro Ile Ser Ala Gly Ala His Thr His Pro Pro Asp Glu 
            500                 505                 510         


Phe Leu Phe Thr Pro Val Val Val Ala Cys Met Ser Ile Met Ala Leu 
        515                 520                 525             


Leu Leu Leu Leu Leu Leu Leu Leu Leu Tyr Lys Tyr Lys Gln Lys Pro 
    530                 535                 540                 


Lys Tyr Gln Val Arg Trp Lys Ile Ile Glu Ser Tyr Glu Gly Asn Ser 
545                 550                 555                 560 


Tyr Thr Phe Ile Asp Pro Thr Gln Leu Pro Tyr Asn Glu Lys Trp Glu 
                565                 570                 575     


Phe Pro Arg Asn Asn Leu Gln Phe Gly Lys Thr Leu Gly Ala Gly Ala 
            580                 585                 590         


Phe Gly Lys Val Val Glu Ala Thr Ala Phe Gly Leu Gly Lys Glu Asp 
        595                 600                 605             


Ala Val Leu Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala His Ala 
    610                 615                 620                 


Asp Glu Lys Glu Ala Leu Met Ser Glu Leu Lys Ile Met Ser His Leu 
625                 630                 635                 640 


Gly Gln His Glu Asn Ile Val Asn Leu Leu Gly Ala Cys Thr His Gly 
                645                 650                 655     


Gly Pro Val Leu Val Ile Thr Glu Tyr Cys Cys Tyr Gly Asp Leu Leu 
            660                 665                 670         


Asn Phe Leu Arg Arg Lys Ala Glu Ala Met Leu Gly Pro Ser Leu Ser 
        675                 680                 685             


Pro Gly Gln Asp Pro Glu Gly Gly Val Asp Tyr Lys Asn Ile His Leu 
    690                 695                 700                 


Glu Lys Lys Tyr Val Arg Arg Asp Ser Gly Phe Ser Ser Gln Gly Val 
705                 710                 715                 720 


Asp Thr Tyr Val Glu Met Arg Pro Val Ser Thr Ser Ser Asn Asp Ser 
                725                 730                 735     


Phe Ser Glu Gln Asp Leu Asp Lys Glu Asp Gly Arg Pro Leu Glu Leu 
            740                 745                 750         


Arg Asp Leu Leu His Phe Ser Ser Gln Val Ala Gln Gly Met Ala Phe 
        755                 760                 765             


Leu Ala Ser Lys Asn Cys Ile His Arg Asp Val Ala Ala Arg Asn Val 
    770                 775                 780                 


Leu Leu Thr Asn Gly His Val Ala Lys Ile Gly Asp Phe Gly Leu Ala 
785                 790                 795                 800 


Arg Asp Ile Met Asn Asp Ser Asn Tyr Ile Val Lys Gly Asn Ala Arg 
                805                 810                 815     


Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asp Cys Val Tyr 
            820                 825                 830         


Thr Val Gln Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu Ile 
        835                 840                 845             


Phe Ser Leu Gly Leu Asn Pro Tyr Pro Gly Ile Leu Val Asn Ser Lys 
    850                 855                 860                 


Phe Tyr Lys Leu Val Lys Asp Gly Tyr Gln Met Ala Gln Pro Ala Phe 
865                 870                 875                 880 


Ala Pro Lys Asn Ile Tyr Ser Ile Met Gln Ala Cys Trp Ala Leu Glu 
                885                 890                 895     


Pro Thr His Arg Pro Thr Phe Gln Gln Ile Cys Ser Phe Leu Gln Glu 
            900                 905                 910         


Gln Ala Gln Glu Asp Arg Arg Glu Arg Asp Tyr Thr Asn Leu Pro Ser 
        915                 920                 925             


Ser Ser Arg Ser Gly Gly Ser Gly Ser Ser Ser Ser Glu Leu Glu Glu 
    930                 935                 940                 


Glu Ser Ser Ser Glu His Leu Thr Cys Cys Glu Gln Gly Asp Ile Ala 
945                 950                 955                 960 


Gln Pro Leu Leu Gln Pro Asn Asn Tyr Gln Phe Cys 
                965                 970         


<210>  3230
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  3230

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe 
                165                 170                 175     


Tyr Ser Phe Leu Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys 
            180                 185                 190         


Arg Ser Pro Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu 
        195                 200                 205             


Pro Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
    210                 215                 220             


<210>  3231
<211>  1447
<212>  PRT
<213>  Homo sapiens

<400>  3231

Met Glu Asn Ser Leu Arg Cys Val Trp Val Pro Lys Leu Ala Phe Val 
1               5                   10                  15      


Leu Phe Gly Ala Ser Leu Phe Ser Ala His Leu Gln Val Thr Gly Phe 
            20                  25                  30          


Gln Ile Lys Ala Phe Thr Ala Leu Arg Phe Leu Ser Glu Pro Ser Asp 
        35                  40                  45              


Ala Val Thr Met Arg Gly Gly Asn Val Leu Leu Asp Cys Ser Ala Glu 
    50                  55                  60                  


Ser Asp Arg Gly Val Pro Val Ile Lys Trp Lys Lys Asp Gly Ile His 
65                  70                  75                  80  


Leu Ala Leu Gly Met Asp Glu Arg Lys Gln Gln Leu Ser Asn Gly Ser 
                85                  90                  95      


Leu Leu Ile Gln Asn Ile Leu His Ser Arg His His Lys Pro Asp Glu 
            100                 105                 110         


Gly Leu Tyr Gln Cys Glu Ala Ser Leu Gly Asp Ser Gly Ser Ile Ile 
        115                 120                 125             


Ser Arg Thr Ala Lys Val Ala Val Ala Gly Pro Leu Arg Phe Leu Ser 
    130                 135                 140                 


Gln Thr Glu Ser Val Thr Ala Phe Met Gly Asp Thr Val Leu Leu Lys 
145                 150                 155                 160 


Cys Glu Val Ile Gly Glu Pro Met Pro Thr Ile His Trp Gln Lys Asn 
                165                 170                 175     


Gln Gln Asp Leu Thr Pro Ile Pro Gly Asp Ser Arg Val Val Val Leu 
            180                 185                 190         


Pro Ser Gly Ala Leu Gln Ile Ser Arg Leu Gln Pro Gly Asp Ile Gly 
        195                 200                 205             


Ile Tyr Arg Cys Ser Ala Arg Asn Pro Ala Ser Ser Arg Thr Gly Asn 
    210                 215                 220                 


Glu Ala Glu Val Arg Ile Leu Ser Asp Pro Gly Leu His Arg Gln Leu 
225                 230                 235                 240 


Tyr Phe Leu Gln Arg Pro Ser Asn Val Val Ala Ile Glu Gly Lys Asp 
                245                 250                 255     


Ala Val Leu Glu Cys Cys Val Ser Gly Tyr Pro Pro Pro Ser Phe Thr 
            260                 265                 270         


Trp Leu Arg Gly Glu Glu Val Ile Gln Leu Arg Ser Lys Lys Tyr Ser 
        275                 280                 285             


Leu Leu Gly Gly Ser Asn Leu Leu Ile Ser Asn Val Thr Asp Asp Asp 
    290                 295                 300                 


Ser Gly Met Tyr Thr Cys Val Val Thr Tyr Lys Asn Glu Asn Ile Ser 
305                 310                 315                 320 


Ala Ser Ala Glu Leu Thr Val Leu Val Pro Pro Trp Phe Leu Asn His 
                325                 330                 335     


Pro Ser Asn Leu Tyr Ala Tyr Glu Ser Met Asp Ile Glu Phe Glu Cys 
            340                 345                 350         


Thr Val Ser Gly Lys Pro Val Pro Thr Val Asn Trp Met Lys Asn Gly 
        355                 360                 365             


Asp Val Val Ile Pro Ser Asp Tyr Phe Gln Ile Val Gly Gly Ser Asn 
    370                 375                 380                 


Leu Arg Ile Leu Gly Val Val Lys Ser Asp Glu Gly Phe Tyr Gln Cys 
385                 390                 395                 400 


Val Ala Glu Asn Glu Ala Gly Asn Ala Gln Thr Ser Ala Gln Leu Ile 
                405                 410                 415     


Val Pro Lys Pro Ala Ile Pro Ser Ser Ser Val Leu Pro Ser Ala Pro 
            420                 425                 430         


Arg Asp Val Val Pro Val Leu Val Ser Ser Arg Phe Val Arg Leu Ser 
        435                 440                 445             


Trp Arg Pro Pro Ala Glu Ala Lys Gly Asn Ile Gln Thr Phe Thr Val 
    450                 455                 460                 


Phe Phe Ser Arg Glu Gly Asp Asn Arg Glu Arg Ala Leu Asn Thr Thr 
465                 470                 475                 480 


Gln Pro Gly Ser Leu Gln Leu Thr Val Gly Asn Leu Lys Pro Glu Ala 
                485                 490                 495     


Met Tyr Thr Phe Arg Val Val Ala Tyr Asn Glu Trp Gly Pro Gly Glu 
            500                 505                 510         


Ser Ser Gln Pro Ile Lys Val Ala Thr Gln Pro Glu Leu Gln Val Pro 
        515                 520                 525             


Gly Pro Val Glu Asn Leu Gln Ala Val Ser Thr Ser Pro Thr Ser Ile 
    530                 535                 540                 


Leu Ile Thr Trp Glu Pro Pro Ala Tyr Ala Asn Gly Pro Val Gln Gly 
545                 550                 555                 560 


Tyr Arg Leu Phe Cys Thr Glu Val Ser Thr Gly Lys Glu Gln Asn Ile 
                565                 570                 575     


Glu Val Asp Gly Leu Ser Tyr Lys Leu Glu Gly Leu Lys Lys Phe Thr 
            580                 585                 590         


Glu Tyr Ser Leu Arg Phe Leu Ala Tyr Asn Arg Tyr Gly Pro Gly Val 
        595                 600                 605             


Ser Thr Asp Asp Ile Thr Val Val Thr Leu Ser Asp Val Pro Ser Ala 
    610                 615                 620                 


Pro Pro Gln Asn Val Ser Leu Glu Val Val Asn Ser Arg Ser Ile Lys 
625                 630                 635                 640 


Val Ser Trp Leu Pro Pro Pro Ser Gly Thr Gln Asn Gly Phe Ile Thr 
                645                 650                 655     


Gly Tyr Lys Ile Arg His Arg Lys Thr Thr Arg Arg Gly Glu Met Glu 
            660                 665                 670         


Thr Leu Glu Pro Asn Asn Leu Trp Tyr Leu Phe Thr Gly Leu Glu Lys 
        675                 680                 685             


Gly Ser Gln Tyr Ser Phe Gln Val Ser Ala Met Thr Val Asn Gly Thr 
    690                 695                 700                 


Gly Pro Pro Ser Asn Trp Tyr Thr Ala Glu Thr Pro Glu Asn Asp Leu 
705                 710                 715                 720 


Asp Glu Ser Gln Val Pro Asp Gln Pro Ser Ser Leu His Val Arg Pro 
                725                 730                 735     


Gln Thr Asn Cys Ile Ile Met Ser Trp Thr Pro Pro Leu Asn Pro Asn 
            740                 745                 750         


Ile Val Val Arg Gly Tyr Ile Ile Gly Tyr Gly Val Gly Ser Pro Tyr 
        755                 760                 765             


Ala Glu Thr Val Arg Val Asp Ser Lys Gln Arg Tyr Tyr Ser Ile Glu 
    770                 775                 780                 


Arg Leu Glu Ser Ser Ser His Tyr Val Ile Ser Leu Lys Ala Phe Asn 
785                 790                 795                 800 


Asn Ala Gly Glu Gly Val Pro Leu Tyr Glu Ser Ala Thr Thr Arg Ser 
                805                 810                 815     


Ile Thr Asp Pro Thr Asp Pro Val Asp Tyr Tyr Pro Leu Leu Asp Asp 
            820                 825                 830         


Phe Pro Thr Ser Val Pro Asp Leu Ser Thr Pro Met Leu Pro Pro Val 
        835                 840                 845             


Gly Val Gln Ala Val Ala Leu Thr His Asp Ala Val Arg Val Ser Trp 
    850                 855                 860                 


Ala Asp Asn Ser Val Pro Lys Asn Gln Lys Thr Ser Glu Val Arg Leu 
865                 870                 875                 880 


Tyr Thr Val Arg Trp Arg Thr Ser Phe Ser Ala Ser Ala Lys Tyr Lys 
                885                 890                 895     


Ser Glu Asp Thr Thr Ser Leu Ser Tyr Thr Ala Thr Gly Leu Lys Pro 
            900                 905                 910         


Asn Thr Met Tyr Glu Phe Ser Val Met Val Thr Lys Asn Arg Arg Ser 
        915                 920                 925             


Ser Thr Trp Ser Met Thr Ala His Ala Thr Thr Tyr Glu Ala Ala Pro 
    930                 935                 940                 


Thr Ser Ala Pro Lys Asp Leu Thr Val Ile Thr Arg Glu Gly Lys Pro 
945                 950                 955                 960 


Arg Ala Val Ile Val Ser Trp Gln Pro Pro Leu Glu Ala Asn Gly Lys 
                965                 970                 975     


Ile Thr Ala Tyr Ile Leu Phe Tyr Thr Leu Asp Lys Asn Ile Pro Ile 
            980                 985                 990         


Asp Asp Trp Ile Met Glu Thr Ile  Ser Gly Asp Arg Leu  Thr His Gln 
        995                 1000                 1005             


Ile Met  Asp Leu Asn Leu Asp  Thr Met Tyr Tyr Phe  Arg Ile Gln 
    1010                 1015                 1020             


Ala Arg  Asn Ser Lys Gly Val  Gly Pro Leu Ser Asp  Pro Ile Leu 
    1025                 1030                 1035             


Phe Arg  Thr Leu Lys Val Glu  His Pro Asp Lys Met  Ala Asn Asp 
    1040                 1045                 1050             


Gln Gly  Arg His Gly Asp Gly  Gly Tyr Trp Pro Val  Asp Thr Asn 
    1055                 1060                 1065             


Leu Ile  Asp Arg Ser Thr Leu  Asn Glu Pro Pro Ile  Gly Gln Met 
    1070                 1075                 1080             


His Pro  Pro His Gly Ser Val  Thr Pro Gln Lys Asn  Ser Asn Leu 
    1085                 1090                 1095             


Leu Val  Ile Ile Val Val Thr  Val Gly Val Ile Thr  Val Leu Val 
    1100                 1105                 1110             


Val Val  Ile Val Ala Val Ile  Cys Thr Arg Arg Ser  Ser Ala Gln 
    1115                 1120                 1125             


Gln Arg  Lys Lys Arg Ala Thr  His Ser Ala Gly Lys  Arg Lys Gly 
    1130                 1135                 1140             


Ser Gln  Lys Asp Leu Arg Pro  Pro Asp Leu Trp Ile  His His Glu 
    1145                 1150                 1155             


Glu Met  Glu Met Lys Asn Ile  Glu Lys Pro Ser Gly  Thr Asp Pro 
    1160                 1165                 1170             


Ala Gly  Arg Asp Ser Pro Ile  Gln Ser Cys Gln Asp  Leu Thr Pro 
    1175                 1180                 1185             


Val Ser  His Ser Gln Ser Glu  Thr Gln Leu Gly Ser  Lys Ser Thr 
    1190                 1195                 1200             


Ser His  Ser Gly Gln Asp Thr  Glu Glu Ala Gly Ser  Ser Met Ser 
    1205                 1210                 1215             


Thr Leu  Glu Arg Ser Leu Ala  Ala Arg Arg Ala Pro  Arg Ala Lys 
    1220                 1225                 1230             


Leu Met  Ile Pro Met Asp Ala  Gln Ser Asn Asn Pro  Ala Val Val 
    1235                 1240                 1245             


Ser Ala  Ile Pro Val Pro Thr  Leu Glu Ser Ala Gln  Tyr Pro Gly 
    1250                 1255                 1260             


Ile Leu  Pro Ser Pro Thr Cys  Gly Tyr Pro His Pro  Gln Phe Thr 
    1265                 1270                 1275             


Leu Arg  Pro Val Pro Phe Pro  Thr Leu Ser Val Asp  Arg Gly Phe 
    1280                 1285                 1290             


Gly Ala  Gly Arg Ser Gln Ser  Val Ser Glu Gly Pro  Thr Thr Gln 
    1295                 1300                 1305             


Gln Pro  Pro Met Leu Pro Pro  Ser Gln Pro Glu His  Ser Ser Ser 
    1310                 1315                 1320             


Glu Glu  Ala Pro Ser Arg Thr  Ile Pro Thr Ala Cys  Val Arg Pro 
    1325                 1330                 1335             


Thr His  Pro Leu Arg Ser Phe  Ala Asn Pro Leu Leu  Pro Pro Pro 
    1340                 1345                 1350             


Met Ser  Ala Ile Glu Pro Lys  Val Pro Tyr Thr Pro  Leu Leu Ser 
    1355                 1360                 1365             


Gln Pro  Gly Pro Thr Leu Pro  Lys Thr His Val Lys  Thr Ala Ser 
    1370                 1375                 1380             


Leu Gly  Leu Ala Gly Lys Ala  Arg Ser Pro Leu Leu  Pro Val Ser 
    1385                 1390                 1395             


Val Pro  Thr Ala Pro Glu Val  Ser Glu Glu Ser His  Lys Pro Thr 
    1400                 1405                 1410             


Glu Asp  Ser Ala Asn Val Tyr  Glu Gln Asp Asp Leu  Ser Glu Gln 
    1415                 1420                 1425             


Met Ala  Ser Leu Glu Gly Leu  Met Lys Gln Leu Asn  Ala Ile Thr 
    1430                 1435                 1440             


Gly Ser  Ala Phe 
    1445         


<210>  3232
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  3232

Met Gly Tyr Phe Arg Cys Ala Gly Ala Gly Ser Phe Gly Arg Arg Arg 
1               5                   10                  15      


Lys Met Glu Pro Ser Thr Ala Ala Arg Ala Trp Ala Leu Phe Trp Leu 
            20                  25                  30          


Leu Leu Pro Leu Leu Gly Ala Val Cys Ala Ser Gly Pro Arg Thr Leu 
        35                  40                  45              


Val Leu Leu Asp Asn Leu Asn Val Arg Glu Thr His Ser Leu Phe Phe 
    50                  55                  60                  


Arg Ser Leu Lys Asp Arg Gly Phe Glu Leu Thr Phe Lys Thr Ala Asp 
65                  70                  75                  80  


Asp Pro Ser Leu Ser Leu Ile Lys Tyr Gly Glu Phe Leu Tyr Asp Asn 
                85                  90                  95      


Leu Ile Ile Phe Ser Pro Ser Val Glu Asp Phe Gly Gly Asn Ile Asn 
            100                 105                 110         


Val Glu Thr Ile Ser Ala Phe Ile Asp Gly Gly Gly Ser Val Leu Val 
        115                 120                 125             


Ala Ala Ser Ser Asp Ile Gly Asp Pro Leu Arg Glu Leu Gly Ser Glu 
    130                 135                 140                 


Cys Gly Ile Glu Phe Asp Glu Glu Lys Thr Ala Val Ile Asp His His 
145                 150                 155                 160 


Asn Tyr Asp Ile Ser Asp Leu Gly Gln His Thr Leu Ile Val Ala Asp 
                165                 170                 175     


Thr Glu Asn Leu Leu Lys Ala Pro Thr Ile Val Gly Lys Ser Ser Leu 
            180                 185                 190         


Asn Pro Ile Leu Phe Arg Gly Val Gly Met Val Ala Asp Pro Asp Asn 
        195                 200                 205             


Pro Leu Val Leu Asp Ile Leu Thr Gly Ser Ser Thr Ser Tyr Ser Phe 
    210                 215                 220                 


Phe Pro Asp Lys Pro Ile Thr Gln Tyr Pro His Ala Val Gly Lys Asn 
225                 230                 235                 240 


Thr Leu Leu Ile Ala Gly Leu Gln Ala Arg Asn Asn Ala Arg Val Ile 
                245                 250                 255     


Phe Ser Gly Ser Leu Asp Phe Phe Ser Asp Ser Phe Phe Asn Ser Ala 
            260                 265                 270         


Val Gln Lys Ala Ala Pro Gly Ser Gln Arg Tyr Ser Gln Thr Gly Asn 
        275                 280                 285             


Tyr Glu Leu Ala Val Ala Leu Ser Arg Trp Val Phe Lys Glu Glu Gly 
    290                 295                 300                 


Val Leu Arg Val Gly Pro Val Ser His His Arg Val Gly Glu Thr Ala 
305                 310                 315                 320 


Pro Pro Asn Ala Tyr Thr Val Thr Asp Leu Val Glu Tyr Ser Ile Val 
                325                 330                 335     


Ile Gln Gln Leu Ser Asn Gly Lys Trp Val Pro Phe Asp Gly Asp Asp 
            340                 345                 350         


Ile Gln Leu Glu Phe Val Arg Ile Asp Pro Phe Val Arg Thr Phe Leu 
        355                 360                 365             


Lys Lys Lys Gly Gly Lys Tyr Ser Val Gln Phe Lys Leu Pro Asp Val 
    370                 375                 380                 


Tyr Gly Val Phe Gln Phe Lys Val Asp Tyr Asn Arg Leu Gly Tyr Thr 
385                 390                 395                 400 


His Leu Tyr Ser Ser Thr Gln Val Ser Val Arg Pro Leu Gln His Thr 
                405                 410                 415     


Gln Tyr Glu Arg Phe Ile Pro Ser Ala Tyr Pro Tyr Tyr Ala Ser Ala 
            420                 425                 430         


Phe Ser Met Met Leu Gly Leu Phe Ile Phe Ser Ile Val Phe Leu His 
        435                 440                 445             


Met Lys Glu Lys Glu Lys Ser Asp 
    450                 455     


<210>  3233
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  3233

Met Arg Gly Met Lys Leu Leu Gly Ala Leu Leu Ala Leu Ala Ala Leu 
1               5                   10                  15      


Leu Gln Gly Ala Val Ser Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr 
            20                  25                  30          


Phe Gly Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val 
        35                  40                  45              


Gln Ile Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp 
    50                  55                  60                  


Ser His Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp 
65                  70                  75                  80  


Ala Pro Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Asn 
                85                  90                  95      


Ser Tyr Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser 
            100                 105                 110         


Ala Val Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Gly Asn 
        115                 120                 125             


Asp Thr Phe Asn Arg Glu Pro Ala Ile Val Arg Phe Phe Ser Arg Phe 
    130                 135                 140                 


Thr Glu Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly 
145                 150                 155                 160 


Asp Ala Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val 
                165                 170                 175     


Gln Glu Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn 
            180                 185                 190         


Ala Gly Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu 
        195                 200                 205             


Trp Thr Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr 
    210                 215                 220                 


Thr Ala Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly 
225                 230                 235                 240 


Met Leu Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn 
                245                 250                 255     


Phe Gln Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser 
            260                 265                 270         


Asp His Tyr Pro Val Glu Val Met Leu Lys 
        275                 280         


<210>  3234
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  3234

Met Ala Thr Ala Leu Pro Pro Arg Leu Gln Pro Val Arg Gly Asn Glu 
1               5                   10                  15      


Thr Leu Arg Glu His Tyr Gln Tyr Val Gly Lys Leu Ala Gly Arg Leu 
            20                  25                  30          


Lys Glu Ala Ser Glu Gly Ser Thr Leu Thr Thr Val Leu Phe Leu Val 
        35                  40                  45              


Ile Cys Ser Phe Ile Val Leu Glu Asn Leu Met Val Leu Ile Ala Ile 
    50                  55                  60                  


Trp Lys Asn Asn Lys Phe His Asn Arg Met Tyr Phe Phe Ile Gly Asn 
65                  70                  75                  80  


Leu Ala Leu Cys Asp Leu Leu Ala Gly Ile Ala Tyr Lys Val Asn Ile 
                85                  90                  95      


Leu Met Ser Gly Lys Lys Thr Phe Ser Leu Ser Pro Thr Val Trp Phe 
            100                 105                 110         


Leu Arg Glu Gly Ser Met Phe Val Ala Leu Gly Ala Ser Thr Cys Ser 
        115                 120                 125             


Leu Leu Ala Ile Ala Ile Glu Arg His Leu Thr Met Ile Lys Met Arg 
    130                 135                 140                 


Pro Tyr Asp Ala Asn Lys Arg His Arg Val Phe Leu Leu Ile Gly Met 
145                 150                 155                 160 


Cys Trp Leu Ile Ala Phe Thr Leu Gly Ala Leu Pro Ile Leu Gly Trp 
                165                 170                 175     


Asn Cys Leu His Asn Leu Pro Asp Cys Ser Thr Ile Leu Pro Leu Tyr 
            180                 185                 190         


Ser Lys Lys Tyr Ile Ala Phe Cys Ile Ser Ile Phe Thr Ala Ile Leu 
        195                 200                 205             


Val Thr Ile Val Ile Leu Tyr Ala Arg Ile Tyr Phe Leu Val Lys Ser 
    210                 215                 220                 


Ser Ser Arg Lys Val Ala Asn His Asn Asn Ser Glu Arg Ser Met Ala 
225                 230                 235                 240 


Leu Leu Arg Thr Val Val Ile Val Val Ser Val Phe Ile Ala Cys Trp 
                245                 250                 255     


Ser Pro Leu Phe Ile Leu Phe Leu Ile Asp Val Ala Cys Arg Val Gln 
            260                 265                 270         


Ala Cys Pro Ile Leu Phe Lys Ala Gln Trp Phe Ile Val Leu Ala Val 
        275                 280                 285             


Leu Asn Ser Ala Met Asn Pro Val Ile Tyr Thr Leu Ala Ser Lys Glu 
    290                 295                 300                 


Met Arg Arg Ala Phe Phe Arg Leu Val Cys Asn Cys Leu Val Arg Gly 
305                 310                 315                 320 


Arg Gly Ala Arg Ala Ser Pro Ile Gln Pro Ala Leu Asp Pro Ser Arg 
                325                 330                 335     


Ser Lys Ser Ser Ser Ser Asn Asn Ser Ser His Ser Pro Lys Val Lys 
            340                 345                 350         


Glu Asp Leu Pro His Thr Ala Pro Ser Ser Cys Ile Met Asp Lys Asn 
        355                 360                 365             


Ala Ala Leu Gln Asn Gly Ile Phe Cys Asn 
    370                 375             


<210>  3235
<211>  1210
<212>  PRT
<213>  Homo sapiens

<400>  3235

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  3236
<211>  976
<212>  PRT
<213>  Homo sapiens

<400>  3236

Met Glu Arg Arg Trp Pro Leu Gly Leu Gly Leu Val Leu Leu Leu Cys 
1               5                   10                  15      


Ala Pro Leu Pro Pro Gly Ala Arg Ala Lys Glu Val Thr Leu Met Asp 
            20                  25                  30          


Thr Ser Lys Ala Gln Gly Glu Leu Gly Trp Leu Leu Asp Pro Pro Lys 
        35                  40                  45              


Asp Gly Trp Ser Glu Gln Gln Gln Ile Leu Asn Gly Thr Pro Leu Tyr 
    50                  55                  60                  


Met Tyr Gln Asp Cys Pro Met Gln Gly Arg Arg Asp Thr Asp His Trp 
65                  70                  75                  80  


Leu Arg Ser Asn Trp Ile Tyr Arg Gly Glu Glu Ala Ser Arg Val His 
                85                  90                  95      


Val Glu Leu Gln Phe Thr Val Arg Asp Cys Lys Ser Phe Pro Gly Gly 
            100                 105                 110         


Ala Gly Pro Leu Gly Cys Lys Glu Thr Phe Asn Leu Leu Tyr Met Glu 
        115                 120                 125             


Ser Asp Gln Asp Val Gly Ile Gln Leu Arg Arg Pro Leu Phe Gln Lys 
    130                 135                 140                 


Val Thr Thr Val Ala Ala Asp Gln Ser Phe Thr Ile Arg Asp Leu Val 
145                 150                 155                 160 


Ser Gly Ser Val Lys Leu Asn Val Glu Arg Cys Ser Leu Gly Arg Leu 
                165                 170                 175     


Thr Arg Arg Gly Leu Tyr Leu Ala Phe His Asn Pro Gly Ala Cys Val 
            180                 185                 190         


Ala Leu Val Ser Val Arg Val Phe Tyr Gln Arg Cys Pro Glu Thr Leu 
        195                 200                 205             


Asn Gly Leu Ala Gln Phe Pro Asp Thr Leu Pro Gly Pro Ala Gly Leu 
    210                 215                 220                 


Val Glu Val Ala Gly Thr Cys Leu Pro His Ala Arg Ala Ser Pro Arg 
225                 230                 235                 240 


Pro Ser Gly Ala Pro Arg Met His Cys Ser Pro Asp Gly Glu Trp Leu 
                245                 250                 255     


Val Pro Val Gly Arg Cys His Cys Glu Pro Gly Tyr Glu Glu Gly Gly 
            260                 265                 270         


Ser Gly Glu Ala Cys Val Ala Cys Pro Ser Gly Ser Tyr Arg Met Asp 
        275                 280                 285             


Met Asp Thr Pro His Cys Leu Thr Cys Pro Gln Gln Ser Thr Ala Glu 
    290                 295                 300                 


Ser Glu Gly Ala Thr Ile Cys Thr Cys Glu Ser Gly His Tyr Arg Ala 
305                 310                 315                 320 


Pro Gly Glu Gly Pro Gln Val Ala Cys Thr Gly Pro Pro Ser Ala Pro 
                325                 330                 335     


Arg Asn Leu Ser Phe Ser Ala Ser Gly Thr Gln Leu Ser Leu Arg Trp 
            340                 345                 350         


Glu Pro Pro Ala Asp Thr Gly Gly Arg Gln Asp Val Arg Tyr Ser Val 
        355                 360                 365             


Arg Cys Ser Gln Cys Gln Gly Thr Ala Gln Asp Gly Gly Pro Cys Gln 
    370                 375                 380                 


Pro Cys Gly Val Gly Val His Phe Ser Pro Gly Ala Arg Gly Leu Thr 
385                 390                 395                 400 


Thr Pro Ala Val His Val Asn Gly Leu Glu Pro Tyr Ala Asn Tyr Thr 
                405                 410                 415     


Phe Asn Val Glu Ala Gln Asn Gly Val Ser Gly Leu Gly Ser Ser Gly 
            420                 425                 430         


His Ala Ser Thr Ser Val Ser Ile Ser Met Gly His Ala Glu Ser Leu 
        435                 440                 445             


Ser Gly Leu Ser Leu Arg Leu Val Lys Lys Glu Pro Arg Gln Leu Glu 
    450                 455                 460                 


Leu Thr Trp Ala Gly Ser Arg Pro Arg Ser Pro Gly Ala Asn Leu Thr 
465                 470                 475                 480 


Tyr Glu Leu His Val Leu Asn Gln Asp Glu Glu Arg Tyr Gln Met Val 
                485                 490                 495     


Leu Glu Pro Arg Val Leu Leu Thr Glu Leu Gln Pro Asp Thr Thr Tyr 
            500                 505                 510         


Ile Val Arg Val Arg Met Leu Thr Pro Leu Gly Pro Gly Pro Phe Ser 
        515                 520                 525             


Pro Asp His Glu Phe Arg Thr Ser Pro Pro Val Ser Arg Gly Leu Thr 
    530                 535                 540                 


Gly Gly Glu Ile Val Ala Val Ile Phe Gly Leu Leu Leu Gly Ala Ala 
545                 550                 555                 560 


Leu Leu Leu Gly Ile Leu Val Phe Arg Ser Arg Arg Ala Gln Arg Gln 
                565                 570                 575     


Arg Gln Gln Arg Gln Arg Asp Arg Ala Thr Asp Val Asp Arg Glu Asp 
            580                 585                 590         


Lys Leu Trp Leu Lys Pro Tyr Val Asp Leu Gln Ala Tyr Glu Asp Pro 
        595                 600                 605             


Ala Gln Gly Ala Leu Asp Phe Thr Arg Glu Leu Asp Pro Ala Trp Leu 
    610                 615                 620                 


Met Val Asp Thr Val Ile Gly Glu Gly Glu Phe Gly Glu Val Tyr Arg 
625                 630                 635                 640 


Gly Thr Leu Arg Leu Pro Ser Gln Asp Cys Lys Thr Val Ala Ile Lys 
                645                 650                 655     


Thr Leu Lys Asp Thr Ser Pro Gly Gly Gln Trp Trp Asn Phe Leu Arg 
            660                 665                 670         


Glu Ala Thr Ile Met Gly Gln Phe Ser His Pro His Ile Leu His Leu 
        675                 680                 685             


Glu Gly Val Val Thr Lys Arg Lys Pro Ile Met Ile Ile Thr Glu Phe 
    690                 695                 700                 


Met Glu Asn Gly Ala Leu Asp Ala Phe Leu Arg Glu Arg Glu Asp Gln 
705                 710                 715                 720 


Leu Val Pro Gly Gln Leu Val Ala Met Leu Gln Gly Ile Ala Ser Gly 
                725                 730                 735     


Met Asn Tyr Leu Ser Asn His Asn Tyr Val His Arg Asp Leu Ala Ala 
            740                 745                 750         


Arg Asn Ile Leu Val Asn Gln Asn Leu Cys Cys Lys Val Ser Asp Phe 
        755                 760                 765             


Gly Leu Thr Arg Leu Leu Asp Asp Phe Asp Gly Thr Tyr Glu Thr Gln 
    770                 775                 780                 


Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala His 
785                 790                 795                 800 


Arg Ile Phe Thr Thr Ala Ser Asp Val Trp Ser Phe Gly Ile Val Met 
                805                 810                 815     


Trp Glu Val Leu Ser Phe Gly Asp Lys Pro Tyr Gly Glu Met Ser Asn 
            820                 825                 830         


Gln Glu Val Met Lys Ser Ile Glu Asp Gly Tyr Arg Leu Pro Pro Pro 
        835                 840                 845             


Val Asp Cys Pro Ala Pro Leu Tyr Glu Leu Met Lys Asn Cys Trp Ala 
    850                 855                 860                 


Tyr Asp Arg Ala Arg Arg Pro His Phe Gln Lys Leu Gln Ala His Leu 
865                 870                 875                 880 


Glu Gln Leu Leu Ala Asn Pro His Ser Leu Arg Thr Ile Ala Asn Phe 
                885                 890                 895     


Asp Pro Arg Met Thr Leu Arg Leu Pro Ser Leu Ser Gly Ser Asp Gly 
            900                 905                 910         


Ile Pro Tyr Arg Thr Val Ser Glu Trp Leu Glu Ser Ile Arg Met Lys 
        915                 920                 925             


Arg Tyr Ile Leu His Phe His Ser Ala Gly Leu Asp Thr Met Glu Cys 
    930                 935                 940                 


Val Leu Glu Leu Thr Ala Glu Asp Leu Thr Gln Met Gly Ile Thr Leu 
945                 950                 955                 960 


Pro Gly His Gln Lys Arg Ile Leu Cys Ser Ile Gln Gly Phe Lys Asp 
                965                 970                 975     


<210>  3237
<211>  983
<212>  PRT
<213>  Homo sapiens

<400>  3237

Met Asp Cys Gln Leu Ser Ile Leu Leu Leu Leu Ser Cys Ser Val Leu 
1               5                   10                  15      


Asp Ser Phe Gly Glu Leu Ile Pro Gln Pro Ser Asn Glu Val Asn Leu 
            20                  25                  30          


Leu Asp Ser Lys Thr Ile Gln Gly Glu Leu Gly Trp Ile Ser Tyr Pro 
        35                  40                  45              


Ser His Gly Trp Glu Glu Ile Ser Gly Val Asp Glu His Tyr Thr Pro 
    50                  55                  60                  


Ile Arg Thr Tyr Gln Val Cys Asn Val Met Asp His Ser Gln Asn Asn 
65                  70                  75                  80  


Trp Leu Arg Thr Asn Trp Val Pro Arg Asn Ser Ala Gln Lys Ile Tyr 
                85                  90                  95      


Val Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Ile Pro Leu Val 
            100                 105                 110         


Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Met Glu Ser Asp 
        115                 120                 125             


Asp Asp His Gly Val Lys Phe Arg Glu His Gln Phe Thr Lys Ile Asp 
    130                 135                 140                 


Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Met Asp Leu Gly Asp Arg 
145                 150                 155                 160 


Ile Leu Lys Leu Asn Thr Glu Ile Arg Glu Val Gly Pro Val Asn Lys 
                165                 170                 175     


Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys Val Ala Leu 
            180                 185                 190         


Val Ser Val Arg Val Tyr Phe Lys Lys Cys Pro Phe Thr Val Lys Asn 
        195                 200                 205             


Leu Ala Met Phe Pro Asp Thr Val Pro Met Asp Ser Gln Ser Leu Val 
    210                 215                 220                 


Glu Val Arg Gly Ser Cys Val Asn Asn Ser Lys Glu Glu Asp Pro Pro 
225                 230                 235                 240 


Arg Met Tyr Cys Ser Thr Glu Gly Glu Trp Leu Val Pro Ile Gly Lys 
                245                 250                 255     


Cys Ser Cys Asn Ala Gly Tyr Glu Glu Arg Gly Phe Met Cys Gln Ala 
            260                 265                 270         


Cys Arg Pro Gly Phe Tyr Lys Ala Leu Asp Gly Asn Met Lys Cys Ala 
        275                 280                 285             


Lys Cys Pro Pro His Ser Ser Thr Gln Glu Asp Gly Ser Met Asn Cys 
    290                 295                 300                 


Arg Cys Glu Asn Asn Tyr Phe Arg Ala Asp Lys Asp Pro Pro Ser Met 
305                 310                 315                 320 


Ala Cys Thr Arg Pro Pro Ser Ser Pro Arg Asn Val Ile Ser Asn Ile 
                325                 330                 335     


Asn Glu Thr Ser Val Ile Leu Asp Trp Ser Trp Pro Leu Asp Thr Gly 
            340                 345                 350         


Gly Arg Lys Asp Val Thr Phe Asn Ile Ile Cys Lys Lys Cys Gly Trp 
        355                 360                 365             


Asn Ile Lys Gln Cys Glu Pro Cys Ser Pro Asn Val Arg Phe Leu Pro 
    370                 375                 380                 


Arg Gln Phe Gly Leu Thr Asn Thr Thr Val Thr Val Thr Asp Leu Leu 
385                 390                 395                 400 


Ala His Thr Asn Tyr Thr Phe Glu Ile Asp Ala Val Asn Gly Val Ser 
                405                 410                 415     


Glu Leu Ser Ser Pro Pro Arg Gln Phe Ala Ala Val Ser Ile Thr Thr 
            420                 425                 430         


Asn Gln Ala Ala Pro Ser Pro Val Leu Thr Ile Lys Lys Asp Arg Thr 
        435                 440                 445             


Ser Arg Asn Ser Ile Ser Leu Ser Trp Gln Glu Pro Glu His Pro Asn 
    450                 455                 460                 


Gly Ile Ile Leu Asp Tyr Glu Val Lys Tyr Tyr Glu Lys Gln Glu Gln 
465                 470                 475                 480 


Glu Thr Ser Tyr Thr Ile Leu Arg Ala Arg Gly Thr Asn Val Thr Ile 
                485                 490                 495     


Ser Ser Leu Lys Pro Asp Thr Ile Tyr Val Phe Gln Ile Arg Ala Arg 
            500                 505                 510         


Thr Ala Ala Gly Tyr Gly Thr Asn Ser Arg Lys Phe Glu Phe Glu Thr 
        515                 520                 525             


Ser Pro Asp Ser Phe Ser Ile Ser Gly Glu Ser Ser Gln Val Val Met 
    530                 535                 540                 


Ile Ala Ile Ser Ala Ala Val Ala Ile Ile Leu Leu Thr Val Val Ile 
545                 550                 555                 560 


Tyr Val Leu Ile Gly Arg Phe Cys Gly Tyr Lys Ser Lys His Gly Ala 
                565                 570                 575     


Asp Glu Lys Arg Leu His Phe Gly Asn Gly His Leu Lys Leu Pro Gly 
            580                 585                 590         


Leu Arg Thr Tyr Val Asp Pro His Thr Tyr Glu Asp Pro Thr Gln Ala 
        595                 600                 605             


Val His Glu Phe Ala Lys Glu Leu Asp Ala Thr Asn Ile Ser Ile Asp 
    610                 615                 620                 


Lys Val Val Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu 
625                 630                 635                 640 


Lys Leu Pro Ser Lys Lys Glu Ile Ser Val Ala Ile Lys Thr Leu Lys 
                645                 650                 655     


Val Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Gly Glu Ala Ser 
            660                 665                 670         


Ile Met Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val 
        675                 680                 685             


Val Thr Lys Ser Lys Pro Val Met Ile Val Thr Glu Tyr Met Glu Asn 
    690                 695                 700                 


Gly Ser Leu Asp Ser Phe Leu Arg Lys His Asp Ala Gln Phe Thr Val 
705                 710                 715                 720 


Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ser Gly Met Lys Tyr 
                725                 730                 735     


Leu Ser Asp Met Gly Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile 
            740                 745                 750         


Leu Ile Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser 
        755                 760                 765             


Arg Val Leu Glu Asp Asp Pro Glu Ala Ala Tyr Thr Thr Arg Gly Gly 
    770                 775                 780                 


Lys Ile Pro Ile Arg Trp Thr Ser Pro Glu Ala Ile Ala Tyr Arg Lys 
785                 790                 795                 800 


Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Leu Trp Glu 
                805                 810                 815     


Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Glu Met Ser Asn Gln Asp 
            820                 825                 830         


Val Ile Lys Ala Val Asp Glu Gly Tyr Arg Leu Pro Pro Pro Met Asp 
        835                 840                 845             


Cys Pro Ala Ala Leu Tyr Gln Leu Met Leu Asp Cys Trp Gln Lys Asp 
    850                 855                 860                 


Arg Asn Asn Arg Pro Lys Phe Glu Gln Ile Val Ser Ile Leu Asp Lys 
865                 870                 875                 880 


Leu Ile Arg Asn Pro Gly Ser Leu Lys Ile Ile Thr Ser Ala Ala Ala 
                885                 890                 895     


Arg Pro Ser Asn Leu Leu Leu Asp Gln Ser Asn Val Asp Ile Thr Thr 
            900                 905                 910         


Phe Arg Thr Thr Gly Asp Trp Leu Asn Gly Val Trp Thr Ala His Cys 
        915                 920                 925             


Lys Glu Ile Phe Thr Gly Val Glu Tyr Ser Ser Cys Asp Thr Ile Ala 
    930                 935                 940                 


Lys Ile Ser Thr Asp Asp Met Lys Lys Val Gly Val Thr Val Val Gly 
945                 950                 955                 960 


Pro Gln Lys Lys Ile Ile Ser Ser Ile Lys Ala Leu Glu Thr Gln Ser 
                965                 970                 975     


Lys Asn Gly Pro Val Pro Val 
            980             


<210>  3238
<211>  1308
<212>  PRT
<213>  Homo sapiens

<400>  3238

Met Lys Pro Ala Thr Gly Leu Trp Val Trp Val Ser Leu Leu Val Ala 
1               5                   10                  15      


Ala Gly Thr Val Gln Pro Ser Asp Ser Gln Ser Val Cys Ala Gly Thr 
            20                  25                  30          


Glu Asn Lys Leu Ser Ser Leu Ser Asp Leu Glu Gln Gln Tyr Arg Ala 
        35                  40                  45              


Leu Arg Lys Tyr Tyr Glu Asn Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Thr Ser Ile Glu His Asn Arg Asp Leu Ser Phe Leu Arg Ser Val 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Leu Asn Gln Phe Arg Tyr 
                85                  90                  95      


Leu Pro Leu Glu Asn Leu Arg Ile Ile Arg Gly Thr Lys Leu Tyr Glu 
            100                 105                 110         


Asp Arg Tyr Ala Leu Ala Ile Phe Leu Asn Tyr Arg Lys Asp Gly Asn 
        115                 120                 125             


Phe Gly Leu Gln Glu Leu Gly Leu Lys Asn Leu Thr Glu Ile Leu Asn 
    130                 135                 140                 


Gly Gly Val Tyr Val Asp Gln Asn Lys Phe Leu Cys Tyr Ala Asp Thr 
145                 150                 155                 160 


Ile His Trp Gln Asp Ile Val Arg Asn Pro Trp Pro Ser Asn Leu Thr 
                165                 170                 175     


Leu Val Ser Thr Asn Gly Ser Ser Gly Cys Gly Arg Cys His Lys Ser 
            180                 185                 190         


Cys Thr Gly Arg Cys Trp Gly Pro Thr Glu Asn His Cys Gln Thr Leu 
        195                 200                 205             


Thr Arg Thr Val Cys Ala Glu Gln Cys Asp Gly Arg Cys Tyr Gly Pro 
    210                 215                 220                 


Tyr Val Ser Asp Cys Cys His Arg Glu Cys Ala Gly Gly Cys Ser Gly 
225                 230                 235                 240 


Pro Lys Asp Thr Asp Cys Phe Ala Cys Met Asn Phe Asn Asp Ser Gly 
                245                 250                 255     


Ala Cys Val Thr Gln Cys Pro Gln Thr Phe Val Tyr Asn Pro Thr Thr 
            260                 265                 270         


Phe Gln Leu Glu His Asn Phe Asn Ala Lys Tyr Thr Tyr Gly Ala Phe 
        275                 280                 285             


Cys Val Lys Lys Cys Pro His Asn Phe Val Val Asp Ser Ser Ser Cys 
    290                 295                 300                 


Val Arg Ala Cys Pro Ser Ser Lys Met Glu Val Glu Glu Asn Gly Ile 
305                 310                 315                 320 


Lys Met Cys Lys Pro Cys Thr Asp Ile Cys Pro Lys Ala Cys Asp Gly 
                325                 330                 335     


Ile Gly Thr Gly Ser Leu Met Ser Ala Gln Thr Val Asp Ser Ser Asn 
            340                 345                 350         


Ile Asp Lys Phe Ile Asn Cys Thr Lys Ile Asn Gly Asn Leu Ile Phe 
        355                 360                 365             


Leu Val Thr Gly Ile His Gly Asp Pro Tyr Asn Ala Ile Glu Ala Ile 
    370                 375                 380                 


Asp Pro Glu Lys Leu Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly 
385                 390                 395                 400 


Phe Leu Asn Ile Gln Ser Trp Pro Pro Asn Met Thr Asp Phe Ser Val 
                405                 410                 415     


Phe Ser Asn Leu Val Thr Ile Gly Gly Arg Val Leu Tyr Ser Gly Leu 
            420                 425                 430         


Ser Leu Leu Ile Leu Lys Gln Gln Gly Ile Thr Ser Leu Gln Phe Gln 
        435                 440                 445             


Ser Leu Lys Glu Ile Ser Ala Gly Asn Ile Tyr Ile Thr Asp Asn Ser 
    450                 455                 460                 


Asn Leu Cys Tyr Tyr His Thr Ile Asn Trp Thr Thr Leu Phe Ser Thr 
465                 470                 475                 480 


Ile Asn Gln Arg Ile Val Ile Arg Asp Asn Arg Lys Ala Glu Asn Cys 
                485                 490                 495     


Thr Ala Glu Gly Met Val Cys Asn His Leu Cys Ser Ser Asp Gly Cys 
            500                 505                 510         


Trp Gly Pro Gly Pro Asp Gln Cys Leu Ser Cys Arg Arg Phe Ser Arg 
        515                 520                 525             


Gly Arg Ile Cys Ile Glu Ser Cys Asn Leu Tyr Asp Gly Glu Phe Arg 
    530                 535                 540                 


Glu Phe Glu Asn Gly Ser Ile Cys Val Glu Cys Asp Pro Gln Cys Glu 
545                 550                 555                 560 


Lys Met Glu Asp Gly Leu Leu Thr Cys His Gly Pro Gly Pro Asp Asn 
                565                 570                 575     


Cys Thr Lys Cys Ser His Phe Lys Asp Gly Pro Asn Cys Val Glu Lys 
            580                 585                 590         


Cys Pro Asp Gly Leu Gln Gly Ala Asn Ser Phe Ile Phe Lys Tyr Ala 
        595                 600                 605             


Asp Pro Asp Arg Glu Cys His Pro Cys His Pro Asn Cys Thr Gln Gly 
    610                 615                 620                 


Cys Asn Gly Pro Thr Ser His Asp Cys Ile Tyr Tyr Pro Trp Thr Gly 
625                 630                 635                 640 


His Ser Thr Leu Pro Gln His Ala Arg Thr Pro Leu Ile Ala Ala Gly 
                645                 650                 655     


Val Ile Gly Gly Leu Phe Ile Leu Val Ile Val Gly Leu Thr Phe Ala 
            660                 665                 670         


Val Tyr Val Arg Arg Lys Ser Ile Lys Lys Lys Arg Ala Leu Arg Arg 
        675                 680                 685             


Phe Leu Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Thr Ala 
    690                 695                 700                 


Pro Asn Gln Ala Gln Leu Arg Ile Leu Lys Glu Thr Glu Leu Lys Arg 
705                 710                 715                 720 


Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile 
                725                 730                 735     


Trp Val Pro Glu Gly Glu Thr Val Lys Ile Pro Val Ala Ile Lys Ile 
            740                 745                 750         


Leu Asn Glu Thr Thr Gly Pro Lys Ala Asn Val Glu Phe Met Asp Glu 
        755                 760                 765             


Ala Leu Ile Met Ala Ser Met Asp His Pro His Leu Val Arg Leu Leu 
    770                 775                 780                 


Gly Val Cys Leu Ser Pro Thr Ile Gln Leu Val Thr Gln Leu Met Pro 
785                 790                 795                 800 


His Gly Cys Leu Leu Glu Tyr Val His Glu His Lys Asp Asn Ile Gly 
                805                 810                 815     


Ser Gln Leu Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Met 
            820                 825                 830         


Tyr Leu Glu Glu Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn 
        835                 840                 845             


Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu 
    850                 855                 860                 


Ala Arg Leu Leu Glu Gly Asp Glu Lys Glu Tyr Asn Ala Asp Gly Gly 
865                 870                 875                 880 


Lys Met Pro Ile Lys Trp Met Ala Leu Glu Cys Ile His Tyr Arg Lys 
                885                 890                 895     


Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Ile Trp Glu 
            900                 905                 910         


Leu Met Thr Phe Gly Gly Lys Pro Tyr Asp Gly Ile Pro Thr Arg Glu 
        915                 920                 925             


Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile 
    930                 935                 940                 


Cys Thr Ile Asp Val Tyr Met Val Met Val Lys Cys Trp Met Ile Asp 
945                 950                 955                 960 


Ala Asp Ser Arg Pro Lys Phe Lys Glu Leu Ala Ala Glu Phe Ser Arg 
                965                 970                 975     


Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Asp Arg 
            980                 985                 990         


Met Lys Leu Pro Ser Pro Asn Asp  Ser Lys Phe Phe Gln  Asn Leu Leu 
        995                 1000                 1005             


Asp Glu  Glu Asp Leu Glu Asp  Met Met Asp Ala Glu  Glu Tyr Leu 
    1010                 1015                 1020             


Val Pro  Gln Ala Phe Asn Ile  Pro Pro Pro Ile Tyr  Thr Ser Arg 
    1025                 1030                 1035             


Ala Arg  Ile Asp Ser Asn Arg  Ser Glu Ile Gly His  Ser Pro Pro 
    1040                 1045                 1050             


Pro Ala  Tyr Thr Pro Met Ser  Gly Asn Gln Phe Val  Tyr Arg Asp 
    1055                 1060                 1065             


Gly Gly  Phe Ala Ala Glu Gln  Gly Val Ser Val Pro  Tyr Arg Ala 
    1070                 1075                 1080             


Pro Thr  Ser Thr Ile Pro Glu  Ala Pro Val Ala Gln  Gly Ala Thr 
    1085                 1090                 1095             


Ala Glu  Ile Phe Asp Asp Ser  Cys Cys Asn Gly Thr  Leu Arg Lys 
    1100                 1105                 1110             


Pro Val  Ala Pro His Val Gln  Glu Asp Ser Ser Thr  Gln Arg Tyr 
    1115                 1120                 1125             


Ser Ala  Asp Pro Thr Val Phe  Ala Pro Glu Arg Ser  Pro Arg Gly 
    1130                 1135                 1140             


Glu Leu  Asp Glu Glu Gly Tyr  Met Thr Pro Met Arg  Asp Lys Pro 
    1145                 1150                 1155             


Lys Gln  Glu Tyr Leu Asn Pro  Val Glu Glu Asn Pro  Phe Val Ser 
    1160                 1165                 1170             


Arg Arg  Lys Asn Gly Asp Leu  Gln Ala Leu Asp Asn  Pro Glu Tyr 
    1175                 1180                 1185             


His Asn  Ala Ser Asn Gly Pro  Pro Lys Ala Glu Asp  Glu Tyr Val 
    1190                 1195                 1200             


Asn Glu  Pro Leu Tyr Leu Asn  Thr Phe Ala Asn Thr  Leu Gly Lys 
    1205                 1210                 1215             


Ala Glu  Tyr Leu Lys Asn Asn  Ile Leu Ser Met Pro  Glu Lys Ala 
    1220                 1225                 1230             


Lys Lys  Ala Phe Asp Asn Pro  Asp Tyr Trp Asn His  Ser Leu Pro 
    1235                 1240                 1245             


Pro Arg  Ser Thr Leu Gln His  Pro Asp Tyr Leu Gln  Glu Tyr Ser 
    1250                 1255                 1260             


Thr Lys  Tyr Phe Tyr Lys Gln  Asn Gly Arg Ile Arg  Pro Ile Val 
    1265                 1270                 1275             


Ala Glu  Asn Pro Glu Tyr Leu  Ser Glu Phe Ser Leu  Lys Pro Gly 
    1280                 1285                 1290             


Thr Val  Leu Pro Pro Pro Pro  Tyr Arg His Arg Asn  Thr Val Val 
    1295                 1300                 1305             


<210>  3239
<211>  397
<212>  PRT
<213>  Homo sapiens

<400>  3239

Met Arg Ser Pro Ser Ala Ala Trp Leu Leu Gly Ala Ala Ile Leu Leu 
1               5                   10                  15      


Ala Ala Ser Leu Ser Cys Ser Gly Thr Ile Gln Gly Thr Asn Arg Ser 
            20                  25                  30          


Ser Lys Gly Arg Ser Leu Ile Gly Lys Val Asp Gly Thr Ser His Val 
        35                  40                  45              


Thr Gly Lys Gly Val Thr Val Glu Thr Val Phe Ser Val Asp Glu Phe 
    50                  55                  60                  


Ser Ala Ser Val Leu Thr Gly Lys Leu Thr Thr Val Phe Leu Pro Ile 
65                  70                  75                  80  


Val Tyr Thr Ile Val Phe Val Val Gly Leu Pro Ser Asn Gly Met Ala 
                85                  90                  95      


Leu Trp Val Phe Leu Phe Arg Thr Lys Lys Lys His Pro Ala Val Ile 
            100                 105                 110         


Tyr Met Ala Asn Leu Ala Leu Ala Asp Leu Leu Ser Val Ile Trp Phe 
        115                 120                 125             


Pro Leu Lys Ile Ala Tyr His Ile His Gly Asn Asn Trp Ile Tyr Gly 
    130                 135                 140                 


Glu Ala Leu Cys Asn Val Leu Ile Gly Phe Phe Tyr Gly Asn Met Tyr 
145                 150                 155                 160 


Cys Ser Ile Leu Phe Met Thr Cys Leu Ser Val Gln Arg Tyr Trp Val 
                165                 170                 175     


Ile Val Asn Pro Met Gly His Ser Arg Lys Lys Ala Asn Ile Ala Ile 
            180                 185                 190         


Gly Ile Ser Leu Ala Ile Trp Leu Leu Ile Leu Leu Val Thr Ile Pro 
        195                 200                 205             


Leu Tyr Val Val Lys Gln Thr Ile Phe Ile Pro Ala Leu Asn Ile Thr 
    210                 215                 220                 


Thr Cys His Asp Val Leu Pro Glu Gln Leu Leu Val Gly Asp Met Phe 
225                 230                 235                 240 


Asn Tyr Phe Leu Ser Leu Ala Ile Gly Val Phe Leu Phe Pro Ala Phe 
                245                 250                 255     


Leu Thr Ala Ser Ala Tyr Val Leu Met Ile Arg Met Leu Arg Ser Ser 
            260                 265                 270         


Ala Met Asp Glu Asn Ser Glu Lys Lys Arg Lys Arg Ala Ile Lys Leu 
        275                 280                 285             


Ile Val Thr Val Leu Ala Met Tyr Leu Ile Cys Phe Thr Pro Ser Asn 
    290                 295                 300                 


Leu Leu Leu Val Val His Tyr Phe Leu Ile Lys Ser Gln Gly Gln Ser 
305                 310                 315                 320 


His Val Tyr Ala Leu Tyr Ile Val Ala Leu Cys Leu Ser Thr Leu Asn 
                325                 330                 335     


Ser Cys Ile Asp Pro Phe Val Tyr Tyr Phe Val Ser His Asp Phe Arg 
            340                 345                 350         


Asp His Ala Lys Asn Ala Leu Leu Cys Arg Ser Val Arg Thr Val Lys 
        355                 360                 365             


Gln Met Gln Val Ser Leu Thr Ser Lys Lys His Ser Arg Lys Ser Ser 
    370                 375                 380                 


Ser Tyr Ser Ser Ser Ser Thr Thr Val Lys Thr Ser Tyr 
385                 390                 395         


<210>  3240
<211>  4588
<212>  PRT
<213>  Homo sapiens

<400>  3240

Met Gly Arg His Leu Ala Leu Leu Leu Leu Leu Leu Leu Leu Phe Gln 
1               5                   10                  15      


His Phe Gly Asp Ser Asp Gly Ser Gln Arg Leu Glu Gln Thr Pro Leu 
            20                  25                  30          


Gln Phe Thr His Leu Glu Tyr Asn Val Thr Val Gln Glu Asn Ser Ala 
        35                  40                  45              


Ala Lys Thr Tyr Val Gly His Pro Val Lys Met Gly Val Tyr Ile Thr 
    50                  55                  60                  


His Pro Ala Trp Glu Val Arg Tyr Lys Ile Val Ser Gly Asp Ser Glu 
65                  70                  75                  80  


Asn Leu Phe Lys Ala Glu Glu Tyr Ile Leu Gly Asp Phe Cys Phe Leu 
                85                  90                  95      


Arg Ile Arg Thr Lys Gly Gly Asn Thr Ala Ile Leu Asn Arg Glu Val 
            100                 105                 110         


Lys Asp His Tyr Thr Leu Ile Val Lys Ala Leu Glu Lys Asn Thr Asn 
        115                 120                 125             


Val Glu Ala Arg Thr Lys Val Arg Val Gln Val Leu Asp Thr Asn Asp 
    130                 135                 140                 


Leu Arg Pro Leu Phe Ser Pro Thr Ser Tyr Ser Val Ser Leu Pro Glu 
145                 150                 155                 160 


Asn Thr Ala Ile Arg Thr Ser Ile Ala Arg Val Ser Ala Thr Asp Ala 
                165                 170                 175     


Asp Ile Gly Thr Asn Gly Glu Phe Tyr Tyr Ser Phe Lys Asp Arg Thr 
            180                 185                 190         


Asp Met Phe Ala Ile His Pro Thr Ser Gly Val Ile Val Leu Thr Gly 
        195                 200                 205             


Arg Leu Asp Tyr Leu Glu Thr Lys Leu Tyr Glu Met Glu Ile Leu Ala 
    210                 215                 220                 


Ala Asp Arg Gly Met Lys Leu Tyr Gly Ser Ser Gly Ile Ser Ser Met 
225                 230                 235                 240 


Ala Lys Leu Thr Val His Ile Glu Gln Ala Asn Glu Cys Ala Pro Val 
                245                 250                 255     


Ile Thr Ala Val Thr Leu Ser Pro Ser Glu Leu Asp Arg Asp Pro Ala 
            260                 265                 270         


Tyr Ala Ile Val Thr Val Asp Asp Cys Asp Gln Gly Ala Asn Gly Asp 
        275                 280                 285             


Ile Ala Ser Leu Ser Ile Val Ala Gly Asp Leu Leu Gln Gln Phe Arg 
    290                 295                 300                 


Thr Val Arg Ser Phe Pro Gly Ser Lys Glu Tyr Lys Val Lys Ala Ile 
305                 310                 315                 320 


Gly Gly Ile Asp Trp Asp Ser His Pro Phe Gly Tyr Asn Leu Thr Leu 
                325                 330                 335     


Gln Ala Lys Asp Lys Gly Thr Pro Pro Gln Phe Ser Ser Val Lys Val 
            340                 345                 350         


Ile His Val Thr Ser Pro Gln Phe Lys Ala Gly Pro Val Lys Phe Glu 
        355                 360                 365             


Lys Asp Val Tyr Arg Ala Glu Ile Ser Glu Phe Ala Pro Pro Asn Thr 
    370                 375                 380                 


Pro Val Val Met Val Lys Ala Ile Pro Ala Tyr Ser His Leu Arg Tyr 
385                 390                 395                 400 


Val Phe Lys Ser Thr Pro Gly Lys Ala Lys Phe Ser Leu Asn Tyr Asn 
                405                 410                 415     


Thr Gly Leu Ile Ser Ile Leu Glu Pro Val Lys Arg Gln Gln Ala Ala 
            420                 425                 430         


His Phe Glu Leu Glu Val Thr Thr Ser Asp Arg Lys Ala Ser Thr Lys 
        435                 440                 445             


Val Leu Val Lys Val Leu Gly Ala Asn Ser Asn Pro Pro Glu Phe Thr 
    450                 455                 460                 


Gln Thr Ala Tyr Lys Ala Ala Phe Asp Glu Asn Val Pro Ile Gly Thr 
465                 470                 475                 480 


Thr Val Met Ser Leu Ser Ala Val Asp Pro Asp Glu Gly Glu Asn Gly 
                485                 490                 495     


Tyr Val Thr Tyr Ser Ile Ala Asn Leu Asn His Val Pro Phe Ala Ile 
            500                 505                 510         


Asp His Phe Thr Gly Ala Val Ser Thr Ser Glu Asn Leu Asp Tyr Glu 
        515                 520                 525             


Leu Met Pro Arg Val Tyr Thr Leu Arg Ile Arg Ala Ser Asp Trp Gly 
    530                 535                 540                 


Leu Pro Tyr Arg Arg Glu Val Glu Val Leu Ala Thr Ile Thr Leu Asn 
545                 550                 555                 560 


Asn Leu Asn Asp Asn Thr Pro Leu Phe Glu Lys Ile Asn Cys Glu Gly 
                565                 570                 575     


Thr Ile Pro Arg Asp Leu Gly Val Gly Glu Gln Ile Thr Thr Val Ser 
            580                 585                 590         


Ala Ile Asp Ala Asp Glu Leu Gln Leu Val Gln Tyr Gln Ile Glu Ala 
        595                 600                 605             


Gly Asn Glu Leu Asp Phe Phe Ser Leu Asn Pro Asn Ser Gly Val Leu 
    610                 615                 620                 


Ser Leu Lys Arg Ser Leu Met Asp Gly Leu Gly Ala Lys Val Ser Phe 
625                 630                 635                 640 


His Ser Leu Arg Ile Thr Ala Thr Asp Gly Glu Asn Phe Ala Thr Pro 
                645                 650                 655     


Leu Tyr Ile Asn Ile Thr Val Ala Ala Ser His Lys Leu Val Asn Leu 
            660                 665                 670         


Gln Cys Glu Glu Thr Gly Val Ala Lys Met Leu Ala Glu Lys Leu Leu 
        675                 680                 685             


Gln Ala Asn Lys Leu His Asn Gln Gly Glu Val Glu Asp Ile Phe Phe 
    690                 695                 700                 


Asp Ser His Ser Val Asn Ala His Ile Pro Gln Phe Arg Ser Thr Leu 
705                 710                 715                 720 


Pro Thr Gly Ile Gln Val Lys Glu Asn Gln Pro Val Gly Ser Ser Val 
                725                 730                 735     


Ile Phe Met Asn Ser Thr Asp Leu Asp Thr Gly Phe Asn Gly Lys Leu 
            740                 745                 750         


Val Tyr Ala Val Ser Gly Gly Asn Glu Asp Ser Cys Phe Met Ile Asp 
        755                 760                 765             


Met Glu Thr Gly Met Leu Lys Ile Leu Ser Pro Leu Asp Arg Glu Thr 
    770                 775                 780                 


Thr Asp Lys Tyr Thr Leu Asn Ile Thr Val Tyr Asp Leu Gly Ile Pro 
785                 790                 795                 800 


Gln Lys Ala Ala Trp Arg Leu Leu His Val Val Val Val Asp Ala Asn 
                805                 810                 815     


Asp Asn Pro Pro Glu Phe Leu Gln Glu Ser Tyr Phe Val Glu Val Ser 
            820                 825                 830         


Glu Asp Lys Glu Val His Ser Glu Ile Ile Gln Val Glu Ala Thr Asp 
        835                 840                 845             


Lys Asp Leu Gly Pro Asn Gly His Val Thr Tyr Ser Ile Val Thr Asp 
    850                 855                 860                 


Thr Asp Thr Phe Ser Ile Asp Ser Val Thr Gly Val Val Asn Ile Ala 
865                 870                 875                 880 


Arg Pro Leu Asp Arg Glu Leu Gln His Glu His Ser Leu Lys Ile Glu 
                885                 890                 895     


Ala Arg Asp Gln Ala Arg Glu Glu Pro Gln Leu Phe Ser Thr Val Val 
            900                 905                 910         


Val Lys Val Ser Leu Glu Asp Val Asn Asp Asn Pro Pro Thr Phe Ile 
        915                 920                 925             


Pro Pro Asn Tyr Arg Val Lys Val Arg Glu Asp Leu Pro Glu Gly Thr 
    930                 935                 940                 


Val Ile Met Trp Leu Glu Ala His Asp Pro Asp Leu Gly Gln Ser Gly 
945                 950                 955                 960 


Gln Val Arg Tyr Ser Leu Leu Asp His Gly Glu Gly Asn Phe Asp Val 
                965                 970                 975     


Asp Lys Leu Ser Gly Ala Val Arg Ile Val Gln Gln Leu Asp Phe Glu 
            980                 985                 990         


Lys Lys Gln Val Tyr Asn Leu Thr  Val Arg Ala Lys Asp  Lys Gly Lys 
        995                 1000                 1005             


Pro Val  Ser Leu Ser Ser Thr  Cys Tyr Val Glu Val  Glu Val Val 
    1010                 1015                 1020             


Asp Val  Asn Glu Asn Leu His  Pro Pro Val Phe Ser  Ser Phe Val 
    1025                 1030                 1035             


Glu Lys  Gly Thr Val Lys Glu  Asp Ala Pro Val Gly  Ser Leu Val 
    1040                 1045                 1050             


Met Thr  Val Ser Ala His Asp  Glu Asp Ala Arg Arg  Asp Gly Glu 
    1055                 1060                 1065             


Ile Arg  Tyr Ser Ile Arg Asp  Gly Ser Gly Val Gly  Val Phe Lys 
    1070                 1075                 1080             


Ile Gly  Glu Glu Thr Gly Val  Ile Glu Thr Ser Asp  Arg Leu Asp 
    1085                 1090                 1095             


Arg Glu  Ser Thr Ser His Tyr  Trp Leu Thr Val Phe  Ala Thr Asp 
    1100                 1105                 1110             


Gln Gly  Val Val Pro Leu Ser  Ser Phe Ile Glu Ile  Tyr Ile Glu 
    1115                 1120                 1125             


Val Glu  Asp Val Asn Asp Asn  Ala Pro Gln Thr Ser  Glu Pro Val 
    1130                 1135                 1140             


Tyr Tyr  Pro Glu Ile Met Glu  Asn Ser Pro Lys Asp  Val Ser Val 
    1145                 1150                 1155             


Val Gln  Ile Glu Ala Phe Asp  Pro Asp Ser Ser Ser  Asn Asp Lys 
    1160                 1165                 1170             


Leu Met  Tyr Lys Ile Thr Ser  Gly Asn Pro Gln Gly  Phe Phe Ser 
    1175                 1180                 1185             


Ile His  Pro Lys Thr Gly Leu  Ile Thr Thr Thr Ser  Arg Lys Leu 
    1190                 1195                 1200             


Asp Arg  Glu Gln Gln Asp Glu  His Ile Leu Glu Val  Thr Val Thr 
    1205                 1210                 1215             


Asp Asn  Gly Ser Pro Pro Lys  Ser Thr Ile Ala Arg  Val Ile Val 
    1220                 1225                 1230             


Lys Ile  Leu Asp Glu Asn Asp  Asn Lys Pro Gln Phe  Leu Gln Lys 
    1235                 1240                 1245             


Phe Tyr  Lys Ile Arg Leu Pro  Glu Arg Glu Lys Pro  Asp Arg Glu 
    1250                 1255                 1260             


Arg Asn  Ala Arg Arg Glu Pro  Leu Tyr His Val Ile  Ala Thr Asp 
    1265                 1270                 1275             


Lys Asp  Glu Gly Pro Asn Ala  Glu Ile Ser Tyr Ser  Ile Glu Asp 
    1280                 1285                 1290             


Gly Asn  Glu His Gly Lys Phe  Phe Ile Glu Pro Lys  Thr Gly Val 
    1295                 1300                 1305             


Val Ser  Ser Lys Arg Phe Ser  Ala Ala Gly Glu Tyr  Asp Ile Leu 
    1310                 1315                 1320             


Ser Ile  Lys Ala Val Asp Asn  Gly Arg Pro Gln Lys  Ser Ser Thr 
    1325                 1330                 1335             


Thr Arg  Leu His Ile Glu Trp  Ile Ser Lys Pro Lys  Pro Ser Leu 
    1340                 1345                 1350             


Glu Pro  Ile Ser Phe Glu Glu  Ser Phe Phe Thr Phe  Thr Val Met 
    1355                 1360                 1365             


Glu Ser  Asp Pro Val Ala His  Met Ile Gly Val Ile  Ser Val Glu 
    1370                 1375                 1380             


Pro Pro  Gly Ile Pro Leu Trp  Phe Asp Ile Thr Gly  Gly Asn Tyr 
    1385                 1390                 1395             


Asp Ser  His Phe Asp Val Asp  Lys Gly Thr Gly Thr  Ile Ile Val 
    1400                 1405                 1410             


Ala Lys  Pro Leu Asp Ala Glu  Gln Lys Ser Asn Tyr  Asn Leu Thr 
    1415                 1420                 1425             


Val Glu  Ala Thr Asp Gly Thr  Thr Thr Ile Leu Thr  Gln Val Phe 
    1430                 1435                 1440             


Ile Lys  Val Ile Asp Thr Asn  Asp His Arg Pro Gln  Phe Ser Thr 
    1445                 1450                 1455             


Ser Lys  Tyr Glu Val Val Ile  Pro Glu Asp Thr Ala  Pro Glu Thr 
    1460                 1465                 1470             


Glu Ile  Leu Gln Ile Ser Ala  Val Asp Gln Asp Glu  Lys Asn Lys 
    1475                 1480                 1485             


Leu Ile  Tyr Thr Leu Gln Ser  Ser Arg Asp Pro Leu  Ser Leu Lys 
    1490                 1495                 1500             


Lys Phe  Arg Leu Asp Pro Ala  Thr Gly Ser Leu Tyr  Thr Ser Glu 
    1505                 1510                 1515             


Lys Leu  Asp His Glu Ala Val  His Gln His Thr Leu  Thr Val Met 
    1520                 1525                 1530             


Val Arg  Asp Gln Asp Val Pro  Val Lys Arg Asn Phe  Ala Arg Ile 
    1535                 1540                 1545             


Val Val  Asn Val Ser Asp Thr  Asn Asp His Ala Pro  Trp Phe Thr 
    1550                 1555                 1560             


Ala Ser  Ser Tyr Lys Gly Arg  Val Tyr Glu Ser Ala  Ala Val Gly 
    1565                 1570                 1575             


Ser Val  Val Leu Gln Val Thr  Ala Leu Asp Lys Asp  Lys Gly Lys 
    1580                 1585                 1590             


Asn Ala  Glu Val Leu Tyr Ser  Ile Glu Ser Gly Asn  Ile Gly Asn 
    1595                 1600                 1605             


Ser Phe  Met Ile Asp Pro Val  Leu Gly Ser Ile Lys  Thr Ala Lys 
    1610                 1615                 1620             


Glu Leu  Asp Arg Ser Asn Gln  Ala Glu Tyr Asp Leu  Met Val Lys 
    1625                 1630                 1635             


Ala Thr  Asp Lys Gly Ser Pro  Pro Met Ser Glu Ile  Thr Ser Val 
    1640                 1645                 1650             


Arg Ile  Phe Val Thr Ile Ala  Asp Asn Ala Ser Pro  Lys Phe Thr 
    1655                 1660                 1665             


Ser Lys  Glu Tyr Ser Val Glu  Leu Ser Glu Thr Val  Ser Ile Gly 
    1670                 1675                 1680             


Ser Phe  Val Gly Met Val Thr  Ala His Ser Gln Ser  Ser Val Val 
    1685                 1690                 1695             


Tyr Glu  Ile Lys Asp Gly Asn  Thr Gly Asp Ala Phe  Asp Ile Asn 
    1700                 1705                 1710             


Pro His  Ser Gly Thr Ile Ile  Thr Gln Lys Ala Leu  Asp Phe Glu 
    1715                 1720                 1725             


Thr Leu  Pro Ile Tyr Thr Leu  Ile Ile Gln Gly Thr  Asn Met Ala 
    1730                 1735                 1740             


Gly Leu  Ser Thr Asn Thr Thr  Val Leu Val His Leu  Gln Asp Glu 
    1745                 1750                 1755             


Asn Asp  Asn Ala Pro Val Phe  Met Gln Ala Glu Tyr  Thr Gly Leu 
    1760                 1765                 1770             


Ile Ser  Glu Ser Ala Ser Ile  Asn Ser Val Val Leu  Thr Asp Arg 
    1775                 1780                 1785             


Asn Val  Pro Leu Val Ile Arg  Ala Ala Asp Ala Asp  Lys Asp Ser 
    1790                 1795                 1800             


Asn Ala  Leu Leu Val Tyr His  Ile Val Glu Pro Ser  Val His Thr 
    1805                 1810                 1815             


Tyr Phe  Ala Ile Asp Ser Ser  Thr Gly Ala Ile His  Thr Val Leu 
    1820                 1825                 1830             


Ser Leu  Asp Tyr Glu Glu Thr  Ser Ile Phe His Phe  Thr Val Gln 
    1835                 1840                 1845             


Val His  Asp Met Gly Thr Pro  Arg Leu Phe Ala Glu  Tyr Ala Ala 
    1850                 1855                 1860             


Asn Val  Thr Val His Val Ile  Asp Ile Asn Asp Cys  Pro Pro Val 
    1865                 1870                 1875             


Phe Ala  Lys Pro Leu Tyr Glu  Ala Ser Leu Leu Leu  Pro Thr Tyr 
    1880                 1885                 1890             


Lys Gly  Val Lys Val Ile Thr  Val Asn Ala Thr Asp  Ala Asp Ser 
    1895                 1900                 1905             


Ser Ala  Phe Ser Gln Leu Ile  Tyr Ser Ile Thr Glu  Gly Asn Ile 
    1910                 1915                 1920             


Gly Glu  Lys Phe Ser Met Asp  Tyr Lys Thr Gly Ala  Leu Thr Val 
    1925                 1930                 1935             


Gln Asn  Thr Thr Gln Leu Arg  Ser Arg Tyr Glu Leu  Thr Val Arg 
    1940                 1945                 1950             


Ala Ser  Asp Gly Arg Phe Ala  Gly Leu Thr Ser Val  Lys Ile Asn 
    1955                 1960                 1965             


Val Lys  Glu Ser Lys Glu Ser  His Leu Lys Phe Thr  Gln Asp Val 
    1970                 1975                 1980             


Tyr Ser  Ala Val Val Lys Glu  Asn Ser Thr Glu Ala  Glu Thr Leu 
    1985                 1990                 1995             


Ala Val  Ile Thr Ala Ile Gly  Asn Pro Ile Asn Glu  Pro Leu Phe 
    2000                 2005                 2010             


Tyr His  Ile Leu Asn Pro Asp  Arg Arg Phe Lys Ile  Ser Arg Thr 
    2015                 2020                 2025             


Ser Gly  Val Leu Ser Thr Thr  Gly Thr Pro Phe Asp  Arg Glu Gln 
    2030                 2035                 2040             


Gln Glu  Ala Phe Asp Val Val  Val Glu Val Thr Glu  Glu His Lys 
    2045                 2050                 2055             


Pro Ser  Ala Val Ala His Val  Val Val Lys Val Ile  Val Glu Asp 
    2060                 2065                 2070             


Gln Asn  Asp Asn Ala Pro Val  Phe Val Asn Leu Pro  Tyr Tyr Ala 
    2075                 2080                 2085             


Val Val  Lys Val Asp Thr Glu  Val Gly His Val Ile  Arg Tyr Val 
    2090                 2095                 2100             


Thr Ala  Val Asp Arg Asp Ser  Gly Arg Asn Gly Glu  Val His Tyr 
    2105                 2110                 2115             


Tyr Leu  Lys Glu His His Glu  His Phe Gln Ile Gly  Pro Leu Gly 
    2120                 2125                 2130             


Glu Ile  Ser Leu Lys Lys Gln  Phe Glu Leu Asp Thr  Leu Asn Lys 
    2135                 2140                 2145             


Glu Tyr  Leu Val Thr Val Val  Ala Lys Asp Gly Gly  Asn Pro Ala 
    2150                 2155                 2160             


Phe Ser  Ala Glu Val Ile Val  Pro Ile Thr Val Met  Asn Lys Ala 
    2165                 2170                 2175             


Met Pro  Val Phe Glu Lys Pro  Phe Tyr Ser Ala Glu  Ile Ala Glu 
    2180                 2185                 2190             


Ser Ile  Gln Val His Ser Pro  Val Val His Val Gln  Ala Asn Ser 
    2195                 2200                 2205             


Pro Glu  Gly Leu Lys Val Phe  Tyr Ser Ile Thr Asp  Gly Asp Pro 
    2210                 2215                 2220             


Phe Ser  Gln Phe Thr Ile Asn  Phe Asn Thr Gly Val  Ile Asn Val 
    2225                 2230                 2235             


Ile Ala  Pro Leu Asp Phe Glu  Ala His Pro Ala Tyr  Lys Leu Ser 
    2240                 2245                 2250             


Ile Arg  Ala Thr Asp Ser Leu  Thr Gly Ala His Ala  Glu Val Phe 
    2255                 2260                 2265             


Val Asp  Ile Ile Val Asp Asp  Ile Asn Asp Asn Pro  Pro Val Phe 
    2270                 2275                 2280             


Ala Gln  Gln Ser Tyr Ala Val  Thr Leu Ser Glu Ala  Ser Val Ile 
    2285                 2290                 2295             


Gly Thr  Ser Val Val Gln Val  Arg Ala Thr Asp Ser  Asp Ser Glu 
    2300                 2305                 2310             


Pro Asn  Arg Gly Ile Ser Tyr  Gln Met Phe Gly Asn  His Ser Lys 
    2315                 2320                 2325             


Ser His  Asp His Phe His Val  Asp Ser Ser Thr Gly  Leu Ile Ser 
    2330                 2335                 2340             


Leu Leu  Arg Thr Leu Asp Tyr  Glu Gln Ser Arg Gln  His Thr Ile 
    2345                 2350                 2355             


Phe Val  Arg Ala Val Asp Gly  Gly Met Pro Thr Leu  Ser Ser Asp 
    2360                 2365                 2370             


Val Ile  Val Thr Val Asp Val  Thr Asp Leu Asn Asp  Asn Pro Pro 
    2375                 2380                 2385             


Leu Phe  Glu Gln Gln Ile Tyr  Glu Ala Arg Ile Ser  Glu His Ala 
    2390                 2395                 2400             


Pro His  Gly His Phe Val Thr  Cys Val Lys Ala Tyr  Asp Ala Asp 
    2405                 2410                 2415             


Ser Ser  Asp Ile Asp Lys Leu  Gln Tyr Ser Ile Leu  Ser Gly Asn 
    2420                 2425                 2430             


Asp His  Lys His Phe Val Ile  Asp Ser Ala Thr Gly  Ile Ile Thr 
    2435                 2440                 2445             


Leu Ser  Asn Leu His Arg His  Ala Leu Lys Pro Phe  Tyr Ser Leu 
    2450                 2455                 2460             


Asn Leu  Ser Val Ser Asp Gly  Val Phe Arg Ser Ser  Thr Gln Val 
    2465                 2470                 2475             


His Val  Thr Val Ile Gly Gly  Asn Leu His Ser Pro  Ala Phe Leu 
    2480                 2485                 2490             


Gln Asn  Glu Tyr Glu Val Glu  Leu Ala Glu Asn Ala  Pro Leu His 
    2495                 2500                 2505             


Thr Leu  Val Met Glu Val Lys  Thr Thr Asp Gly Asp  Ser Gly Ile 
    2510                 2515                 2520             


Tyr Gly  His Val Thr Tyr His  Ile Val Asn Asp Phe  Ala Lys Asp 
    2525                 2530                 2535             


Arg Phe  Tyr Ile Asn Glu Arg  Gly Gln Ile Phe Thr  Leu Glu Lys 
    2540                 2545                 2550             


Leu Asp  Arg Glu Thr Pro Ala  Glu Lys Val Ile Ser  Val Arg Leu 
    2555                 2560                 2565             


Met Ala  Lys Asp Ala Gly Gly  Lys Val Ala Phe Cys  Thr Val Asn 
    2570                 2575                 2580             


Val Ile  Leu Thr Asp Asp Asn  Asp Asn Ala Pro Gln  Phe Arg Ala 
    2585                 2590                 2595             


Thr Lys  Tyr Glu Val Asn Ile  Gly Ser Ser Ala Ala  Lys Gly Thr 
    2600                 2605                 2610             


Ser Val  Val Lys Val Leu Ala  Ser Asp Ala Asp Glu  Gly Ser Asn 
    2615                 2620                 2625             


Ala Asp  Ile Thr Tyr Ala Ile  Glu Ala Asp Ser Glu  Ser Val Lys 
    2630                 2635                 2640             


Glu Asn  Leu Glu Ile Asn Lys  Leu Ser Gly Val Ile  Thr Thr Lys 
    2645                 2650                 2655             


Glu Ser  Leu Ile Gly Leu Glu  Asn Glu Phe Phe Thr  Phe Phe Val 
    2660                 2665                 2670             


Arg Ala  Val Asp Asn Gly Ser  Pro Ser Lys Glu Ser  Val Val Leu 
    2675                 2680                 2685             


Val Tyr  Val Lys Ile Leu Pro  Pro Glu Met Gln Leu  Pro Lys Phe 
    2690                 2695                 2700             


Ser Glu  Pro Phe Tyr Thr Phe  Thr Val Ser Glu Asp  Val Pro Ile 
    2705                 2710                 2715             


Gly Thr  Glu Ile Asp Leu Ile  Arg Ala Glu His Ser  Gly Thr Val 
    2720                 2725                 2730             


Leu Tyr  Ser Leu Val Lys Gly  Asn Thr Pro Glu Ser  Asn Arg Asp 
    2735                 2740                 2745             


Glu Ser  Phe Val Ile Asp Arg  Gln Ser Gly Arg Leu  Lys Leu Glu 
    2750                 2755                 2760             


Lys Ser  Leu Asp His Glu Thr  Thr Lys Trp Tyr Gln  Phe Ser Ile 
    2765                 2770                 2775             


Leu Ala  Arg Cys Thr Gln Asp  Asp His Glu Met Val  Ala Ser Val 
    2780                 2785                 2790             


Asp Val  Ser Ile Gln Val Lys  Asp Ala Asn Asp Asn  Ser Pro Val 
    2795                 2800                 2805             


Phe Glu  Ser Ser Pro Tyr Glu  Ala Phe Ile Val Glu  Asn Leu Pro 
    2810                 2815                 2820             


Gly Gly  Ser Arg Val Ile Gln  Ile Arg Ala Ser Asp  Ala Asp Ser 
    2825                 2830                 2835             


Gly Thr  Asn Gly Gln Val Met  Tyr Ser Leu Asp Gln  Ser Gln Ser 
    2840                 2845                 2850             


Val Glu  Val Ile Glu Ser Phe  Ala Ile Asn Met Glu  Thr Gly Trp 
    2855                 2860                 2865             


Ile Thr  Thr Leu Lys Glu Leu  Asp His Glu Lys Arg  Asp Asn Tyr 
    2870                 2875                 2880             


Gln Ile  Lys Val Val Ala Ser  Asp His Gly Glu Lys  Ile Gln Leu 
    2885                 2890                 2895             


Ser Ser  Thr Ala Ile Val Asp  Val Thr Val Thr Asp  Val Asn Asp 
    2900                 2905                 2910             


Ser Pro  Pro Arg Phe Thr Ala  Glu Ile Tyr Lys Gly  Thr Val Ser 
    2915                 2920                 2925             


Glu Asp  Asp Pro Gln Gly Gly  Val Ile Ala Ile Leu  Ser Thr Thr 
    2930                 2935                 2940             


Asp Ala  Asp Ser Glu Glu Ile  Asn Arg Gln Val Thr  Tyr Phe Ile 
    2945                 2950                 2955             


Thr Gly  Gly Asp Pro Leu Gly  Gln Phe Ala Val Glu  Thr Ile Gln 
    2960                 2965                 2970             


Asn Glu  Trp Lys Val Tyr Val  Lys Lys Pro Leu Asp  Arg Glu Lys 
    2975                 2980                 2985             


Arg Asp  Asn Tyr Leu Leu Thr  Ile Thr Ala Thr Asp  Gly Thr Phe 
    2990                 2995                 3000             


Ser Ser  Lys Ala Ile Val Glu  Val Lys Val Leu Asp  Ala Asn Asp 
    3005                 3010                 3015             


Asn Ser  Pro Val Cys Glu Lys  Thr Leu Tyr Ser Asp  Thr Ile Pro 
    3020                 3025                 3030             


Glu Asp  Val Leu Pro Gly Lys  Leu Ile Met Gln Ile  Ser Ala Thr 
    3035                 3040                 3045             


Asp Ala  Asp Ile Arg Ser Asn  Ala Glu Ile Thr Tyr  Thr Leu Leu 
    3050                 3055                 3060             


Gly Ser  Gly Ala Glu Lys Phe  Lys Leu Asn Pro Asp  Thr Gly Glu 
    3065                 3070                 3075             


Leu Lys  Thr Ser Thr Pro Leu  Asp Arg Glu Glu Gln  Ala Val Tyr 
    3080                 3085                 3090             


His Leu  Leu Val Arg Ala Thr  Asp Gly Gly Gly Arg  Phe Cys Gln 
    3095                 3100                 3105             


Ala Ser  Ile Val Leu Thr Leu  Glu Asp Val Asn Asp  Asn Ala Pro 
    3110                 3115                 3120             


Glu Phe  Ser Ala Asp Pro Tyr  Ala Ile Thr Val Phe  Glu Asn Thr 
    3125                 3130                 3135             


Glu Pro  Gly Thr Leu Leu Thr  Arg Val Gln Ala Thr  Asp Ala Asp 
    3140                 3145                 3150             


Ala Gly  Leu Asn Arg Lys Ile  Leu Tyr Ser Leu Ile  Asp Ser Ala 
    3155                 3160                 3165             


Asp Gly  Gln Phe Ser Ile Asn  Glu Leu Ser Gly Ile  Ile Gln Leu 
    3170                 3175                 3180             


Glu Lys  Pro Leu Asp Arg Glu  Leu Gln Ala Val Tyr  Thr Leu Ser 
    3185                 3190                 3195             


Leu Lys  Ala Val Asp Gln Gly  Leu Pro Arg Arg Leu  Thr Ala Thr 
    3200                 3205                 3210             


Gly Thr  Val Ile Val Ser Val  Leu Asp Ile Asn Asp  Asn Pro Pro 
    3215                 3220                 3225             


Val Phe  Glu Tyr Arg Glu Tyr  Gly Ala Thr Val Ser  Glu Asp Ile 
    3230                 3235                 3240             


Leu Val  Gly Thr Glu Val Leu  Gln Val Tyr Ala Ala  Ser Arg Asp 
    3245                 3250                 3255             


Ile Glu  Ala Asn Ala Glu Ile  Thr Tyr Ser Ile Ile  Ser Gly Asn 
    3260                 3265                 3270             


Glu His  Gly Lys Phe Ser Ile  Asp Ser Lys Thr Gly  Ala Val Phe 
    3275                 3280                 3285             


Ile Ile  Glu Asn Leu Asp Tyr  Glu Ser Ser His Glu  Tyr Tyr Leu 
    3290                 3295                 3300             


Thr Val  Glu Ala Thr Asp Gly  Gly Thr Pro Ser Leu  Ser Asp Val 
    3305                 3310                 3315             


Ala Thr  Val Asn Val Asn Val  Thr Asp Ile Asn Asp  Asn Thr Pro 
    3320                 3325                 3330             


Val Phe  Ser Gln Asp Thr Tyr  Thr Thr Val Ile Ser  Glu Asp Ala 
    3335                 3340                 3345             


Val Leu  Glu Gln Ser Val Ile  Thr Val Met Ala Asp  Asp Ala Asp 
    3350                 3355                 3360             


Gly Pro  Ser Asn Ser His Ile  His Tyr Ser Ile Ile  Asp Gly Asn 
    3365                 3370                 3375             


Gln Gly  Ser Ser Phe Thr Ile  Asp Pro Val Arg Gly  Glu Val Lys 
    3380                 3385                 3390             


Val Thr  Lys Leu Leu Asp Arg  Glu Thr Ile Ser Gly  Tyr Thr Leu 
    3395                 3400                 3405             


Thr Val  Gln Ala Ser Asp Asn  Gly Ser Pro Pro Arg  Val Asn Thr 
    3410                 3415                 3420             


Thr Thr  Val Asn Ile Asp Val  Ser Asp Val Asn Asp  Asn Ala Pro 
    3425                 3430                 3435             


Val Phe  Ser Arg Gly Asn Tyr  Ser Val Ile Ile Gln  Glu Asn Lys 
    3440                 3445                 3450             


Pro Val  Gly Phe Ser Val Leu  Gln Leu Val Val Thr  Asp Glu Asp 
    3455                 3460                 3465             


Ser Ser  His Asn Gly Pro Pro  Phe Phe Phe Thr Ile  Val Thr Gly 
    3470                 3475                 3480             


Asn Asp  Glu Lys Ala Phe Glu  Val Asn Pro Gln Gly  Val Leu Leu 
    3485                 3490                 3495             


Thr Ser  Ser Ala Ile Lys Arg  Lys Glu Lys Asp His  Tyr Leu Leu 
    3500                 3505                 3510             


Gln Val  Lys Val Ala Asp Asn  Gly Lys Pro Gln Leu  Ser Ser Leu 
    3515                 3520                 3525             


Thr Tyr  Ile Asp Ile Arg Val  Ile Glu Glu Ser Ile  Tyr Pro Pro 
    3530                 3535                 3540             


Ala Ile  Leu Pro Leu Glu Ile  Phe Ile Thr Ser Ser  Gly Glu Glu 
    3545                 3550                 3555             


Tyr Ser  Gly Gly Val Ile Gly  Lys Ile His Ala Thr  Asp Gln Asp 
    3560                 3565                 3570             


Val Tyr  Asp Thr Leu Thr Tyr  Ser Leu Asp Pro Gln  Met Asp Asn 
    3575                 3580                 3585             


Leu Phe  Ser Val Ser Ser Thr  Gly Gly Lys Leu Ile  Ala His Lys 
    3590                 3595                 3600             


Lys Leu  Asp Ile Gly Gln Tyr  Leu Leu Asn Val Ser  Val Thr Asp 
    3605                 3610                 3615             


Gly Lys  Phe Thr Thr Val Ala  Asp Ile Thr Val His  Ile Arg Gln 
    3620                 3625                 3630             


Val Thr  Gln Glu Met Leu Asn  His Thr Ile Ala Ile  Arg Phe Ala 
    3635                 3640                 3645             


Asn Leu  Thr Pro Glu Glu Phe  Val Gly Asp Tyr Trp  Arg Asn Phe 
    3650                 3655                 3660             


Gln Arg  Ala Leu Arg Asn Ile  Leu Gly Val Arg Arg  Asn Asp Ile 
    3665                 3670                 3675             


Gln Ile  Val Ser Leu Gln Ser  Ser Glu Pro His Pro  His Leu Asp 
    3680                 3685                 3690             


Val Leu  Leu Phe Val Glu Lys  Pro Gly Ser Ala Gln  Ile Ser Thr 
    3695                 3700                 3705             


Lys Gln  Leu Leu His Lys Ile  Asn Ser Ser Val Thr  Asp Ile Glu 
    3710                 3715                 3720             


Glu Ile  Ile Gly Val Arg Ile  Leu Asn Val Phe Gln  Lys Leu Cys 
    3725                 3730                 3735             


Ala Gly  Leu Asp Cys Pro Trp  Lys Phe Cys Asp Glu  Lys Val Ser 
    3740                 3745                 3750             


Val Asp  Glu Ser Val Met Ser  Thr His Ser Thr Ala  Arg Leu Ser 
    3755                 3760                 3765             


Phe Val  Thr Pro Arg His His  Arg Ala Ala Val Cys  Leu Cys Lys 
    3770                 3775                 3780             


Glu Gly  Arg Cys Pro Pro Val  His His Gly Cys Glu  Asp Asp Pro 
    3785                 3790                 3795             


Cys Pro  Glu Gly Ser Glu Cys  Val Ser Asp Pro Trp  Glu Glu Lys 
    3800                 3805                 3810             


His Thr  Cys Val Cys Pro Ser  Gly Arg Phe Gly Gln  Cys Pro Gly 
    3815                 3820                 3825             


Ser Ser  Ser Met Thr Leu Thr  Gly Asn Ser Tyr Val  Lys Tyr Arg 
    3830                 3835                 3840             


Leu Thr  Glu Asn Glu Asn Lys  Leu Glu Met Lys Leu  Thr Met Arg 
    3845                 3850                 3855             


Leu Arg  Thr Tyr Ser Thr His  Ala Val Val Met Tyr  Ala Arg Gly 
    3860                 3865                 3870             


Thr Asp  Tyr Ser Ile Leu Glu  Ile His His Gly Arg  Leu Gln Tyr 
    3875                 3880                 3885             


Lys Phe  Asp Cys Gly Ser Gly  Pro Gly Ile Val Ser  Val Gln Ser 
    3890                 3895                 3900             


Ile Gln  Val Asn Asp Gly Gln  Trp His Ala Val Ala  Leu Glu Val 
    3905                 3910                 3915             


Asn Gly  Asn Tyr Ala Arg Leu  Val Leu Asp Gln Val  His Thr Ala 
    3920                 3925                 3930             


Ser Gly  Thr Ala Pro Gly Thr  Leu Lys Thr Leu Asn  Leu Asp Asn 
    3935                 3940                 3945             


Tyr Val  Phe Phe Gly Gly His  Ile Arg Gln Gln Gly  Thr Arg His 
    3950                 3955                 3960             


Gly Arg  Ser Pro Gln Val Gly  Asn Gly Phe Arg Gly  Cys Met Asp 
    3965                 3970                 3975             


Ser Ile  Tyr Leu Asn Gly Gln  Glu Leu Pro Leu Asn  Ser Lys Pro 
    3980                 3985                 3990             


Arg Ser  Tyr Ala His Ile Glu  Glu Ser Val Asp Val  Ser Pro Gly 
    3995                 4000                 4005             


Cys Phe  Leu Thr Ala Thr Glu  Asp Cys Ala Ser Asn  Pro Cys Gln 
    4010                 4015                 4020             


Asn Gly  Gly Val Cys Asn Pro  Ser Pro Ala Gly Gly  Tyr Tyr Cys 
    4025                 4030                 4035             


Lys Cys  Ser Ala Leu Tyr Ile  Gly Thr His Cys Glu  Ile Ser Val 
    4040                 4045                 4050             


Asn Pro  Cys Ser Ser Lys Pro  Cys Leu Tyr Gly Gly  Thr Cys Val 
    4055                 4060                 4065             


Val Asp  Asn Gly Gly Phe Val  Cys Gln Cys Arg Gly  Leu Tyr Thr 
    4070                 4075                 4080             


Gly Gln  Arg Cys Gln Leu Ser  Pro Tyr Cys Lys Asp  Glu Pro Cys 
    4085                 4090                 4095             


Lys Asn  Gly Gly Thr Cys Phe  Asp Ser Leu Asp Gly  Ala Val Cys 
    4100                 4105                 4110             


Gln Cys  Asp Ser Gly Phe Arg  Gly Glu Arg Cys Gln  Ser Asp Ile 
    4115                 4120                 4125             


Asp Glu  Cys Ser Gly Asn Pro  Cys Leu His Gly Ala  Leu Cys Glu 
    4130                 4135                 4140             


Asn Thr  His Gly Ser Tyr His  Cys Asn Cys Ser His  Glu Tyr Arg 
    4145                 4150                 4155             


Gly Arg  His Cys Glu Asp Ala  Ala Pro Asn Gln Tyr  Val Ser Thr 
    4160                 4165                 4170             


Pro Trp  Asn Ile Gly Leu Ala  Glu Gly Ile Gly Ile  Val Val Phe 
    4175                 4180                 4185             


Val Ala  Gly Ile Phe Leu Leu  Val Val Val Phe Val  Leu Cys Arg 
    4190                 4195                 4200             


Lys Met  Ile Ser Arg Lys Lys  Lys His Gln Ala Glu  Pro Lys Asp 
    4205                 4210                 4215             


Lys His  Leu Gly Pro Ala Thr  Ala Phe Leu Gln Arg  Pro Tyr Phe 
    4220                 4225                 4230             


Asp Ser  Lys Leu Asn Lys Asn  Ile Tyr Ser Asp Ile  Pro Pro Gln 
    4235                 4240                 4245             


Val Pro  Val Arg Pro Ile Ser  Tyr Thr Pro Ser Ile  Pro Ser Asp 
    4250                 4255                 4260             


Ser Arg  Asn Asn Leu Asp Arg  Asn Ser Phe Glu Gly  Ser Ala Ile 
    4265                 4270                 4275             


Pro Glu  His Pro Glu Phe Ser  Thr Phe Asn Pro Glu  Ser Val His 
    4280                 4285                 4290             


Gly His  Arg Lys Ala Val Ala  Val Cys Ser Val Ala  Pro Asn Leu 
    4295                 4300                 4305             


Pro Pro  Pro Pro Pro Ser Asn  Ser Pro Ser Asp Ser  Asp Ser Ile 
    4310                 4315                 4320             


Gln Lys  Pro Ser Trp Asp Phe  Asp Tyr Asp Thr Lys  Val Val Asp 
    4325                 4330                 4335             


Leu Asp  Pro Cys Leu Ser Lys  Lys Pro Leu Glu Glu  Lys Pro Ser 
    4340                 4345                 4350             


Gln Pro  Tyr Ser Ala Arg Glu  Ser Leu Ser Glu Val  Gln Ser Leu 
    4355                 4360                 4365             


Ser Ser  Phe Gln Ser Glu Ser  Cys Asp Asp Asn Gly  Tyr His Trp 
    4370                 4375                 4380             


Asp Thr  Ser Asp Trp Met Pro  Ser Val Pro Leu Pro  Asp Ile Gln 
    4385                 4390                 4395             


Glu Phe  Pro Asn Tyr Glu Val  Ile Asp Glu Gln Thr  Pro Leu Tyr 
    4400                 4405                 4410             


Ser Ala  Asp Pro Asn Ala Ile  Asp Thr Asp Tyr Tyr  Pro Gly Gly 
    4415                 4420                 4425             


Tyr Asp  Ile Glu Ser Asp Phe  Pro Pro Pro Pro Glu  Asp Phe Pro 
    4430                 4435                 4440             


Ala Ala  Asp Glu Leu Pro Pro  Leu Pro Pro Glu Phe  Ser Asn Gln 
    4445                 4450                 4455             


Phe Glu  Ser Ile His Pro Pro  Arg Asp Met Pro Ala  Ala Gly Ser 
    4460                 4465                 4470             


Leu Gly  Ser Ser Ser Arg Asn  Arg Gln Arg Phe Asn  Leu Asn Gln 
    4475                 4480                 4485             


Tyr Leu  Pro Asn Phe Tyr Pro  Leu Asp Met Ser Glu  Pro Gln Thr 
    4490                 4495                 4500             


Lys Gly  Thr Gly Glu Asn Ser  Thr Cys Arg Glu Pro  His Ala Pro 
    4505                 4510                 4515             


Tyr Pro  Pro Gly Tyr Gln Arg  His Phe Glu Ala Pro  Ala Val Glu 
    4520                 4525                 4530             


Ser Met  Pro Met Ser Val Tyr  Ala Ser Thr Ala Ser  Cys Ser Asp 
    4535                 4540                 4545             


Val Ser  Ala Cys Cys Glu Val  Glu Ser Glu Val Met  Met Ser Asp 
    4550                 4555                 4560             


Tyr Glu  Ser Gly Asp Asp Gly  His Phe Glu Glu Val  Thr Ile Pro 
    4565                 4570                 4575             


Pro Leu  Asp Ser Gln Gln His  Thr Glu Val 
    4580                 4585             


<210>  3241
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  3241

Met Ala Arg Pro Asn Lys Phe Leu Leu Trp Phe Cys Cys Phe Ala Trp 
1               5                   10                  15      


Leu Cys Phe Pro Ile Ser Leu Gly Ser Gln Ala Ser Gly Gly Glu Ala 
            20                  25                  30          


Gln Ile Ala Ala Ser Ala Glu Leu Glu Ser Gly Ala Met Pro Trp Ser 
        35                  40                  45              


Leu Leu Gln His Ile Asp Glu Arg Asp Arg Ala Gly Leu Leu Pro Ala 
    50                  55                  60                  


Leu Phe Lys Val Leu Ser Val Gly Arg Gly Gly Ser Pro Arg Leu Gln 
65                  70                  75                  80  


Pro Asp Ser Arg Ala Leu His Tyr Met Lys Lys Leu Tyr Lys Thr Tyr 
                85                  90                  95      


Ala Thr Lys Glu Gly Ile Pro Lys Ser Asn Arg Ser His Leu Tyr Asn 
            100                 105                 110         


Thr Val Arg Leu Phe Thr Pro Cys Thr Arg His Lys Gln Ala Pro Gly 
        115                 120                 125             


Asp Gln Val Thr Gly Ile Leu Pro Ser Val Glu Leu Leu Phe Asn Leu 
    130                 135                 140                 


Asp Arg Ile Thr Thr Val Glu His Leu Leu Lys Ser Val Leu Leu Tyr 
145                 150                 155                 160 


Asn Ile Asn Asn Ser Val Ser Phe Ser Ser Ala Val Lys Cys Val Cys 
                165                 170                 175     


Asn Leu Met Ile Lys Glu Pro Lys Ser Ser Ser Arg Thr Leu Gly Arg 
            180                 185                 190         


Ala Pro Tyr Ser Phe Thr Phe Asn Ser Gln Phe Glu Phe Gly Lys Lys 
        195                 200                 205             


His Lys Trp Ile Gln Ile Asp Val Thr Ser Leu Leu Gln Pro Leu Val 
    210                 215                 220                 


Ala Ser Asn Lys Arg Ser Ile His Met Ser Ile Asn Phe Thr Cys Met 
225                 230                 235                 240 


Lys Asp Gln Leu Glu His Pro Ser Ala Gln Asn Gly Leu Phe Asn Met 
                245                 250                 255     


Thr Leu Val Ser Pro Ser Leu Ile Leu Tyr Leu Asn Asp Thr Ser Ala 
            260                 265                 270         


Gln Ala Tyr His Ser Trp Tyr Ser Leu His Tyr Lys Arg Arg Pro Ser 
        275                 280                 285             


Gln Gly Pro Asp Gln Glu Arg Ser Leu Ser Ala Tyr Pro Val Gly Glu 
    290                 295                 300                 


Glu Ala Ala Glu Asp Gly Arg Ser Ser His His Arg His Arg Arg Gly 
305                 310                 315                 320 


Gln Glu Thr Val Ser Ser Glu Leu Lys Lys Pro Leu Gly Pro Ala Ser 
                325                 330                 335     


Phe Asn Leu Ser Glu Tyr Phe Arg Gln Phe Leu Leu Pro Gln Asn Glu 
            340                 345                 350         


Cys Glu Leu His Asp Phe Arg Leu Ser Phe Ser Gln Leu Lys Trp Asp 
        355                 360                 365             


Asn Trp Ile Val Ala Pro His Arg Tyr Asn Pro Arg Tyr Cys Lys Gly 
    370                 375                 380                 


Asp Cys Pro Arg Ala Val Gly His Arg Tyr Gly Ser Pro Val His Thr 
385                 390                 395                 400 


Met Val Gln Asn Ile Ile Tyr Glu Lys Leu Asp Ser Ser Val Pro Arg 
                405                 410                 415     


Pro Ser Cys Val Pro Ala Lys Tyr Ser Pro Leu Ser Val Leu Thr Ile 
            420                 425                 430         


Glu Pro Asp Gly Ser Ile Ala Tyr Lys Glu Tyr Glu Asp Met Ile Ala 
        435                 440                 445             


Thr Lys Cys Thr Cys Arg 
    450                 


<210>  3242
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  3242

Met Gly Asp Trp Ser Phe Leu Gly Asn Phe Leu Glu Glu Val His Lys 
1               5                   10                  15      


His Ser Thr Val Val Gly Lys Val Trp Leu Thr Val Leu Phe Ile Phe 
            20                  25                  30          


Arg Met Leu Val Leu Gly Thr Ala Ala Glu Ser Ser Trp Gly Asp Glu 
        35                  40                  45              


Gln Ala Asp Phe Arg Cys Asp Thr Ile Gln Pro Gly Cys Gln Asn Val 
    50                  55                  60                  


Cys Tyr Asp Gln Ala Phe Pro Ile Ser His Ile Arg Tyr Trp Val Leu 
65                  70                  75                  80  


Gln Ile Ile Phe Val Ser Thr Pro Ser Leu Val Tyr Met Gly His Ala 
                85                  90                  95      


Met His Thr Val Arg Met Gln Glu Lys Arg Lys Leu Arg Glu Ala Glu 
            100                 105                 110         


Arg Ala Lys Glu Val Arg Gly Ser Gly Ser Tyr Glu Tyr Pro Val Ala 
        115                 120                 125             


Glu Lys Ala Glu Leu Ser Cys Trp Glu Glu Gly Asn Gly Arg Ile Ala 
    130                 135                 140                 


Leu Gln Gly Thr Leu Leu Asn Thr Tyr Val Cys Ser Ile Leu Ile Arg 
145                 150                 155                 160 


Thr Thr Met Glu Val Gly Phe Ile Val Gly Gln Tyr Phe Ile Tyr Gly 
                165                 170                 175     


Ile Phe Leu Thr Thr Leu His Val Cys Arg Arg Ser Pro Cys Pro His 
            180                 185                 190         


Pro Val Asn Cys Tyr Val Ser Arg Pro Thr Glu Lys Asn Val Phe Ile 
        195                 200                 205             


Val Phe Met Leu Ala Val Ala Ala Leu Ser Leu Leu Leu Ser Leu Ala 
    210                 215                 220                 


Glu Leu Tyr His Leu Gly Trp Lys Lys Ile Arg Gln Arg Phe Val Lys 
225                 230                 235                 240 


Pro Arg Gln His Met Ala Lys Cys Gln Leu Ser Gly Pro Ser Val Gly 
                245                 250                 255     


Ile Val Gln Ser Cys Thr Pro Pro Pro Asp Phe Asn Gln Cys Leu Glu 
            260                 265                 270         


Asn Gly Pro Gly Gly Lys Phe Phe Asn Pro Phe Ser Asn Asn Met Ala 
        275                 280                 285             


Ser Gln Gln Asn Thr Asp Asn Leu Val Thr Glu Gln Val Arg Gly Gln 
    290                 295                 300                 


Glu Gln Thr Pro Gly Glu Gly Phe Ile Gln Val Arg Tyr Gly Gln Lys 
305                 310                 315                 320 


Pro Glu Val Pro Asn Gly Val Ser Pro Gly His Arg Leu Pro His Gly 
                325                 330                 335     


Tyr His Ser Asp Lys Arg Arg Leu Ser Lys Ala Ser Ser Lys Ala Arg 
            340                 345                 350         


Ser Asp Asp Leu Ser Val 
        355             


<210>  3243
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  3243

Met Gly Asp Trp Ser Phe Leu Gly Asn Ile Leu Glu Glu Val Asn Glu 
1               5                   10                  15      


His Ser Thr Val Ile Gly Arg Val Trp Leu Thr Val Leu Phe Ile Phe 
            20                  25                  30          


Arg Ile Leu Ile Leu Gly Thr Ala Ala Glu Phe Val Trp Gly Asp Glu 
        35                  40                  45              


Gln Ser Asp Phe Val Cys Asn Thr Gln Gln Pro Gly Cys Glu Asn Val 
    50                  55                  60                  


Cys Tyr Asp Glu Ala Phe Pro Ile Ser His Ile Arg Leu Trp Val Leu 
65                  70                  75                  80  


Gln Ile Ile Phe Val Ser Thr Pro Ser Leu Met Tyr Val Gly His Ala 
                85                  90                  95      


Val His Tyr Val Arg Met Glu Glu Lys Arg Lys Ser Arg Glu Ala Glu 
            100                 105                 110         


Glu Leu Gly Gln Gln Ala Gly Thr Asn Gly Gly Pro Asp Gln Gly Ser 
        115                 120                 125             


Val Lys Lys Ser Ser Gly Ser Lys Gly Thr Lys Lys Phe Arg Leu Glu 
    130                 135                 140                 


Gly Thr Leu Leu Arg Thr Tyr Ile Cys His Ile Ile Phe Lys Thr Leu 
145                 150                 155                 160 


Phe Glu Val Gly Phe Ile Val Gly His Tyr Phe Leu Tyr Gly Phe Arg 
                165                 170                 175     


Ile Leu Pro Leu Tyr Arg Cys Ser Arg Trp Pro Cys Pro Asn Val Val 
            180                 185                 190         


Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr Ile Phe Ile Leu Phe 
        195                 200                 205             


Met Leu Ser Val Ala Ser Val Ser Leu Phe Leu Asn Val Met Glu Leu 
    210                 215                 220                 


Gly His Leu Gly Leu Lys Gly Ile Arg Ser Ala Leu Lys Arg Pro Val 
225                 230                 235                 240 


Glu Gln Pro Leu Gly Glu Ile Pro Glu Lys Ser Leu His Ser Ile Ala 
                245                 250                 255     


Val Ser Ser Ile Gln Lys Ala Lys Gly Tyr Gln Leu Leu Glu Glu Glu 
            260                 265                 270         


Lys Ile Val Ser His Tyr Phe Pro Leu Thr Glu Val Gly Met Val Glu 
        275                 280                 285             


Thr Ser Pro Leu Pro Ala Lys Pro Phe Asn Gln Phe Glu Glu Lys Ile 
    290                 295                 300                 


Ser Thr Gly Pro Leu Gly Asp Leu Ser Arg Gly Tyr Gln Glu Thr Leu 
305                 310                 315                 320 


Pro Ser Tyr Ala Gln Val Gly Ala Gln Glu Val Glu Gly Glu Gly Pro 
                325                 330                 335     


Pro Ala Glu Glu Gly Ala Glu Pro Glu Val Gly Glu Lys Lys Glu Glu 
            340                 345                 350         


Ala Glu Arg Leu Thr Thr Glu Glu Gln Glu Lys Val Ala Val Pro Glu 
        355                 360                 365             


Gly Glu Lys Val Glu Thr Pro Gly Val Asp Lys Glu Gly Glu Lys Glu 
    370                 375                 380                 


Glu Pro Gln Ser Glu Lys Val Ser Lys Gln Gly Leu Pro Ala Glu Lys 
385                 390                 395                 400 


Thr Pro Ser Leu Cys Pro Glu Leu Thr Thr Asp Asp Ala Arg Pro Leu 
                405                 410                 415     


Ser Arg Leu Ser Lys Ala Ser Ser Arg Ala Arg Ser Asp Asp Leu Thr 
            420                 425                 430         


Val 
    


<210>  3244
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  3244

Met Asn Trp Ser Ile Phe Glu Gly Leu Leu Ser Gly Val Asn Lys Tyr 
1               5                   10                  15      


Ser Thr Ala Phe Gly Arg Ile Trp Leu Ser Leu Val Phe Ile Phe Arg 
            20                  25                  30          


Val Leu Val Tyr Leu Val Thr Ala Glu Arg Val Trp Ser Asp Asp His 
        35                  40                  45              


Lys Asp Phe Asp Cys Asn Thr Arg Gln Pro Gly Cys Ser Asn Val Cys 
    50                  55                  60                  


Phe Asp Glu Phe Phe Pro Val Ser His Val Arg Leu Trp Ala Leu Gln 
65                  70                  75                  80  


Leu Ile Leu Val Thr Cys Pro Ser Leu Leu Val Val Met His Val Ala 
                85                  90                  95      


Tyr Arg Glu Val Gln Glu Lys Arg His Arg Glu Ala His Gly Glu Asn 
            100                 105                 110         


Ser Gly Arg Leu Tyr Leu Asn Pro Gly Lys Lys Arg Gly Gly Leu Trp 
        115                 120                 125             


Trp Thr Tyr Val Cys Ser Leu Val Phe Lys Ala Ser Val Asp Ile Ala 
    130                 135                 140                 


Phe Leu Tyr Val Phe His Ser Phe Tyr Pro Lys Tyr Ile Leu Pro Pro 
145                 150                 155                 160 


Val Val Lys Cys His Ala Asp Pro Cys Pro Asn Ile Val Asp Cys Phe 
                165                 170                 175     


Ile Ser Lys Pro Ser Glu Lys Asn Ile Phe Thr Leu Phe Met Val Ala 
            180                 185                 190         


Thr Ala Ala Ile Cys Ile Leu Leu Asn Leu Val Glu Leu Ile Tyr Leu 
        195                 200                 205             


Val Ser Lys Arg Cys His Glu Cys Leu Ala Ala Arg Lys Ala Gln Ala 
    210                 215                 220                 


Met Cys Thr Gly His His Pro His Gly Thr Thr Ser Ser Cys Lys Gln 
225                 230                 235                 240 


Asp Asp Leu Leu Ser Gly Asp Leu Ile Phe Leu Gly Ser Asp Ser His 
                245                 250                 255     


Pro Pro Leu Leu Pro Asp Arg Pro Arg Asp His Val Lys Lys Thr Ile 
            260                 265                 270         


Leu 
    


<210>  3245
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  3245

Met Ser Glu Leu Glu Gln Leu Arg Gln Glu Ala Glu Gln Leu Arg Asn 
1               5                   10                  15      


Gln Ile Arg Asp Ala Arg Lys Ala Cys Gly Asp Ser Thr Leu Thr Gln 
            20                  25                  30          


Ile Thr Ala Gly Leu Asp Pro Val Gly Arg Ile Gln Met Arg Thr Arg 
        35                  40                  45              


Arg Thr Leu Arg Gly His Leu Ala Lys Ile Tyr Ala Met His Trp Gly 
    50                  55                  60                  


Thr Asp Ser Arg Leu Leu Val Ser Ala Ser Gln Asp Gly Lys Leu Ile 
65                  70                  75                  80  


Ile Trp Asp Ser Tyr Thr Thr Asn Lys Val His Ala Ile Pro Leu Arg 
                85                  90                  95      


Ser Ser Trp Val Met Thr Cys Ala Tyr Ala Pro Ser Gly Asn Phe Val 
            100                 105                 110         


Ala Cys Gly Gly Leu Asp Asn Ile Cys Ser Ile Tyr Ser Leu Lys Thr 
        115                 120                 125             


Arg Glu Gly Asn Val Arg Val Ser Arg Glu Leu Pro Gly His Thr Gly 
    130                 135                 140                 


Tyr Leu Ser Cys Cys Arg Phe Leu Asp Asp Asn Gln Ile Ile Thr Ser 
145                 150                 155                 160 


Ser Gly Asp Thr Thr Cys Ala Leu Trp Asp Ile Glu Thr Gly Gln Gln 
                165                 170                 175     


Thr Val Gly Phe Ala Gly His Ser Gly Asp Val Met Ser Leu Ser Leu 
            180                 185                 190         


Ala Pro Asp Gly Arg Thr Phe Val Ser Gly Ala Cys Asp Ala Ser Ile 
        195                 200                 205             


Lys Leu Trp Asp Val Arg Asp Ser Met Cys Arg Gln Thr Phe Ile Gly 
    210                 215                 220                 


His Glu Ser Asp Ile Asn Ala Val Ala Phe Phe Pro Asn Gly Tyr Ala 
225                 230                 235                 240 


Phe Thr Thr Gly Ser Asp Asp Ala Thr Cys Arg Leu Phe Asp Leu Arg 
                245                 250                 255     


Ala Asp Gln Glu Leu Leu Met Tyr Ser His Asp Asn Ile Ile Cys Gly 
            260                 265                 270         


Ile Thr Ser Val Ala Phe Ser Arg Ser Gly Arg Leu Leu Leu Ala Gly 
        275                 280                 285             


Tyr Asp Asp Phe Asn Cys Asn Ile Trp Asp Ala Met Lys Gly Asp Arg 
    290                 295                 300                 


Ala Gly Val Leu Ala Gly His Asp Asn Arg Val Ser Cys Leu Gly Val 
305                 310                 315                 320 


Thr Asp Asp Gly Met Ala Val Ala Thr Gly Ser Trp Asp Ser Phe Leu 
                325                 330                 335     


Lys Ile Trp Asn 
            340 


<210>  3246
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  3246

Met Glu Glu Asn Met Glu Glu Gly Gln Thr Gln Lys Gly Cys Phe Glu 
1               5                   10                  15      


Cys Cys Ile Lys Cys Leu Gly Gly Ile Pro Tyr Ala Ser Leu Ile Ala 
            20                  25                  30          


Thr Ile Leu Leu Tyr Ala Gly Val Ala Leu Phe Cys Gly Cys Gly His 
        35                  40                  45              


Glu Ala Leu Ser Gly Thr Val Asn Ile Leu Gln Thr Tyr Phe Glu Met 
    50                  55                  60                  


Ala Arg Thr Ala Gly Asp Thr Leu Asp Val Phe Thr Met Ile Asp Ile 
65                  70                  75                  80  


Phe Lys Tyr Val Ile Tyr Gly Ile Ala Ala Ala Phe Phe Val Tyr Gly 
                85                  90                  95      


Ile Leu Leu Met Val Glu Gly Phe Phe Thr Thr Gly Ala Ile Lys Asp 
            100                 105                 110         


Leu Tyr Gly Asp Phe Lys Ile Thr Thr Cys Gly Arg Cys Val Ser Ala 
        115                 120                 125             


Trp Phe Ile Met Leu Thr Tyr Leu Phe Met Leu Ala Trp Leu Gly Val 
    130                 135                 140                 


Thr Ala Phe Thr Ser Leu Pro Val Tyr Met Tyr Phe Asn Leu Trp Thr 
145                 150                 155                 160 


Ile Cys Arg Asn Thr Thr Leu Val Glu Gly Ala Asn Leu Cys Leu Asp 
                165                 170                 175     


Leu Arg Gln Phe Gly Ile Val Thr Ile Gly Glu Glu Lys Lys Ile Cys 
            180                 185                 190         


Thr Val Ser Glu Asn Phe Leu Arg Met Cys Glu Ser Thr Glu Leu Asn 
        195                 200                 205             


Met Thr Phe His Leu Phe Ile Val Ala Leu Ala Gly Ala Gly Ala Ala 
    210                 215                 220                 


Val Ile Ala Met Val His Tyr Leu Met Val Leu Ser Ala Asn Trp Ala 
225                 230                 235                 240 


Tyr Val Lys Asp Ala Cys Arg Met Gln Lys Tyr Glu Asp Ile Lys Ser 
                245                 250                 255     


Lys Glu Glu Gln Glu Leu His Asp Ile His Ser Thr Arg Ser Lys Glu 
            260                 265                 270         


Arg Leu Asn Ala Tyr Thr 
        275             


<210>  3247
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  3247

Met Lys Pro Ala Met Glu Thr Ala Ala Glu Glu Asn Thr Glu Gln Ser 
1               5                   10                  15      


Gln Glu Arg Lys Gly Cys Phe Glu Cys Cys Ile Lys Cys Leu Gly Gly 
            20                  25                  30          


Val Pro Tyr Ala Ser Leu Val Ala Thr Ile Leu Cys Phe Ser Gly Val 
        35                  40                  45              


Ala Leu Phe Cys Gly Cys Gly His Val Ala Leu Ala Gly Thr Val Ala 
    50                  55                  60                  


Ile Leu Glu Gln His Phe Ser Thr Asn Ala Ser Asp His Ala Leu Leu 
65                  70                  75                  80  


Ser Glu Val Ile Gln Leu Met Gln Tyr Val Ile Tyr Gly Ile Ala Ser 
                85                  90                  95      


Phe Phe Phe Leu Tyr Gly Ile Ile Leu Leu Ala Glu Gly Phe Tyr Thr 
            100                 105                 110         


Thr Ser Ala Val Lys Glu Leu His Gly Glu Phe Lys Thr Thr Ala Cys 
        115                 120                 125             


Gly Arg Cys Ile Ser Gly Met Phe Val Phe Leu Thr Tyr Val Leu Gly 
    130                 135                 140                 


Val Ala Trp Leu Gly Val Phe Gly Phe Ser Ala Val Pro Val Phe Met 
145                 150                 155                 160 


Phe Tyr Asn Ile Trp Ser Thr Cys Glu Val Ile Lys Ser Pro Gln Thr 
                165                 170                 175     


Asn Gly Thr Thr Gly Val Glu Gln Ile Cys Val Asp Ile Arg Gln Tyr 
            180                 185                 190         


Gly Ile Ile Pro Trp Asn Ala Phe Pro Gly Lys Ile Cys Gly Ser Ala 
        195                 200                 205             


Leu Glu Asn Ile Cys Asn Thr Asn Glu Phe Tyr Met Ser Tyr His Leu 
    210                 215                 220                 


Phe Ile Val Ala Cys Ala Gly Ala Gly Ala Thr Val Ile Ala Leu Leu 
225                 230                 235                 240 


Ile Tyr Met Met Ala Thr Thr Tyr Asn Tyr Ala Val Leu Lys Phe Lys 
                245                 250                 255     


Ser Arg Glu Asp Cys Cys Thr Lys Phe 
            260                 265 


<210>  3248
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  3248

Met Glu Asp Leu Glu Glu Thr Leu Phe Glu Glu Phe Glu Asn Tyr Ser 
1               5                   10                  15      


Tyr Asp Leu Asp Tyr Tyr Ser Leu Glu Ser Asp Leu Glu Glu Lys Val 
            20                  25                  30          


Gln Leu Gly Val Val His Trp Val Ser Leu Val Leu Tyr Cys Leu Ala 
        35                  40                  45              


Phe Val Leu Gly Ile Pro Gly Asn Ala Ile Val Ile Trp Phe Thr Gly 
    50                  55                  60                  


Phe Lys Trp Lys Lys Thr Val Thr Thr Leu Trp Phe Leu Asn Leu Ala 
65                  70                  75                  80  


Ile Ala Asp Phe Ile Phe Leu Leu Phe Leu Pro Leu Tyr Ile Ser Tyr 
                85                  90                  95      


Val Ala Met Asn Phe His Trp Pro Phe Gly Ile Trp Leu Cys Lys Ala 
            100                 105                 110         


Asn Ser Phe Thr Ala Gln Leu Asn Met Phe Ala Ser Val Phe Phe Leu 
        115                 120                 125             


Thr Val Ile Ser Leu Asp His Tyr Ile His Leu Ile His Pro Val Leu 
    130                 135                 140                 


Ser His Arg His Arg Thr Leu Lys Asn Ser Leu Ile Val Ile Ile Phe 
145                 150                 155                 160 


Ile Trp Leu Leu Ala Ser Leu Ile Gly Gly Pro Ala Leu Tyr Phe Arg 
                165                 170                 175     


Asp Thr Val Glu Phe Asn Asn His Thr Leu Cys Tyr Asn Asn Phe Gln 
            180                 185                 190         


Lys His Asp Pro Asp Leu Thr Leu Ile Arg His His Val Leu Thr Trp 
        195                 200                 205             


Val Lys Phe Ile Ile Gly Tyr Leu Phe Pro Leu Leu Thr Met Ser Ile 
    210                 215                 220                 


Cys Tyr Leu Cys Leu Ile Phe Lys Val Lys Lys Arg Ser Ile Leu Ile 
225                 230                 235                 240 


Ser Ser Arg His Phe Trp Thr Ile Leu Val Val Val Val Ala Phe Val 
                245                 250                 255     


Val Cys Trp Thr Pro Tyr His Leu Phe Ser Ile Trp Glu Leu Thr Ile 
            260                 265                 270         


His His Asn Ser Tyr Ser His His Val Met Gln Ala Gly Ile Pro Leu 
        275                 280                 285             


Ser Thr Gly Leu Ala Phe Leu Asn Ser Cys Leu Asn Pro Ile Leu Tyr 
    290                 295                 300                 


Val Leu Ile Ser Lys Lys Phe Gln Ala Arg Phe Arg Ser Ser Val Ala 
305                 310                 315                 320 


Glu Ile Leu Lys Tyr Thr Leu Trp Glu Val Ser Cys Ser Gly Thr Val 
                325                 330                 335     


Ser Glu Gln Leu Arg Asn Ser Glu Thr Lys Asn Leu Cys Leu Leu Glu 
            340                 345                 350         


Thr Ala Gln 
        355 


<210>  3249
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  3249

Met Met Trp Gly Ala Gly Ser Pro Leu Ala Trp Leu Ser Ala Gly Ser 
1               5                   10                  15      


Gly Asn Val Asn Val Ser Ser Val Gly Pro Ala Glu Gly Pro Thr Gly 
            20                  25                  30          


Pro Ala Ala Pro Leu Pro Ser Pro Lys Ala Trp Asp Val Val Leu Cys 
        35                  40                  45              


Ile Ser Gly Thr Leu Val Ser Cys Glu Asn Ala Leu Val Val Ala Ile 
    50                  55                  60                  


Ile Val Gly Thr Pro Ala Phe Arg Ala Pro Met Phe Leu Leu Val Gly 
65                  70                  75                  80  


Ser Leu Ala Val Ala Asp Leu Leu Ala Gly Leu Gly Leu Val Leu His 
                85                  90                  95      


Phe Ala Ala Val Phe Cys Ile Gly Ser Ala Glu Met Ser Leu Val Leu 
            100                 105                 110         


Val Gly Val Leu Ala Met Ala Phe Thr Ala Ser Ile Gly Ser Leu Leu 
        115                 120                 125             


Ala Ile Thr Val Asp Arg Tyr Leu Ser Leu Tyr Asn Ala Leu Thr Tyr 
    130                 135                 140                 


Tyr Ser Glu Thr Thr Val Thr Arg Thr Tyr Val Met Leu Ala Leu Val 
145                 150                 155                 160 


Trp Gly Gly Ala Leu Gly Leu Gly Leu Leu Pro Val Leu Ala Trp Asn 
                165                 170                 175     


Cys Leu Asp Gly Leu Thr Thr Cys Gly Val Val Tyr Pro Leu Ser Lys 
            180                 185                 190         


Asn His Leu Val Val Leu Ala Ile Ala Phe Phe Met Val Phe Gly Ile 
        195                 200                 205             


Met Leu Gln Leu Tyr Ala Gln Ile Cys Arg Ile Val Cys Arg His Ala 
    210                 215                 220                 


Gln Gln Ile Ala Leu Gln Arg His Leu Leu Pro Ala Ser His Tyr Val 
225                 230                 235                 240 


Ala Thr Arg Lys Gly Ile Ala Thr Leu Ala Val Val Leu Gly Ala Phe 
                245                 250                 255     


Ala Ala Cys Trp Leu Pro Phe Thr Val Tyr Cys Leu Leu Gly Asp Ala 
            260                 265                 270         


His Ser Pro Pro Leu Tyr Thr Tyr Leu Thr Leu Leu Pro Ala Thr Tyr 
        275                 280                 285             


Asn Ser Met Ile Asn Pro Ile Ile Tyr Ala Phe Arg Asn Gln Asp Val 
    290                 295                 300                 


Gln Lys Val Leu Trp Ala Val Cys Cys Cys Cys Ser Ser Ser Lys Ile 
305                 310                 315                 320 


Pro Phe Arg Ser Arg Ser Pro Ser Asp Val 
                325                 330 


<210>  3250
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  3250

Met Gly Asn His Thr Trp Glu Gly Cys His Val Asp Ser Arg Val Asp 
1               5                   10                  15      


His Leu Phe Pro Pro Ser Leu Tyr Ile Phe Val Ile Gly Val Gly Leu 
            20                  25                  30          


Pro Thr Asn Cys Leu Ala Leu Trp Ala Ala Tyr Arg Gln Val Gln Gln 
        35                  40                  45              


Arg Asn Glu Leu Gly Val Tyr Leu Met Asn Leu Ser Ile Ala Asp Leu 
    50                  55                  60                  


Leu Tyr Ile Cys Thr Leu Pro Leu Trp Val Asp Tyr Phe Leu His His 
65                  70                  75                  80  


Asp Asn Trp Ile His Gly Pro Gly Ser Cys Lys Leu Phe Gly Phe Ile 
                85                  90                  95      


Phe Tyr Thr Asn Ile Tyr Ile Ser Ile Ala Phe Leu Cys Cys Ile Ser 
            100                 105                 110         


Val Asp Arg Tyr Leu Ala Val Ala His Pro Leu Arg Phe Ala Arg Leu 
        115                 120                 125             


Arg Arg Val Lys Thr Ala Val Ala Val Ser Ser Val Val Trp Ala Thr 
    130                 135                 140                 


Glu Leu Gly Ala Asn Ser Ala Pro Leu Phe His Asp Glu Leu Phe Arg 
145                 150                 155                 160 


Asp Arg Tyr Asn His Thr Phe Cys Phe Glu Lys Phe Pro Met Glu Gly 
                165                 170                 175     


Trp Val Ala Trp Met Asn Leu Tyr Arg Val Phe Val Gly Phe Leu Phe 
            180                 185                 190         


Pro Trp Ala Leu Met Leu Leu Ser Tyr Arg Gly Ile Leu Arg Ala Val 
        195                 200                 205             


Arg Gly Ser Val Ser Thr Glu Arg Gln Glu Lys Ala Lys Ile Lys Arg 
    210                 215                 220                 


Leu Ala Leu Ser Leu Ile Ala Ile Val Leu Val Cys Phe Ala Pro Tyr 
225                 230                 235                 240 


His Val Leu Leu Leu Ser Arg Ser Ala Ile Tyr Leu Gly Arg Pro Trp 
                245                 250                 255     


Asp Cys Gly Phe Glu Glu Arg Val Phe Ser Ala Tyr His Ser Ser Leu 
            260                 265                 270         


Ala Phe Thr Ser Leu Asn Cys Val Ala Asp Pro Ile Leu Tyr Cys Leu 
        275                 280                 285             


Val Asn Glu Gly Ala Arg Ser Asp Val Ala Lys Ala Leu His Asn Leu 
    290                 295                 300                 


Leu Arg Phe Leu Ala Ser Asp Lys Pro Gln Glu Met Ala Asn Ala Ser 
305                 310                 315                 320 


Leu Thr Leu Glu Thr Pro Leu Thr Ser Lys Arg Asn Ser Thr Ala Lys 
                325                 330                 335     


Ala Met Thr Gly Ser Trp Ala Ala Thr Pro Pro Ser Gln Gly Asp Gln 
            340                 345                 350         


Val Gln Leu Lys Met Leu Pro Pro Ala Gln 
        355                 360         


<210>  3251
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  3251

Met Glu Ser Ser Gly Asn Pro Glu Ser Thr Thr Phe Phe Tyr Tyr Asp 
1               5                   10                  15      


Leu Gln Ser Gln Pro Cys Glu Asn Gln Ala Trp Val Phe Ala Thr Leu 
            20                  25                  30          


Ala Thr Thr Val Leu Tyr Cys Leu Val Phe Leu Leu Ser Leu Val Gly 
        35                  40                  45              


Asn Ser Leu Val Leu Trp Val Leu Val Lys Tyr Glu Ser Leu Glu Ser 
    50                  55                  60                  


Leu Thr Asn Ile Phe Ile Leu Asn Leu Cys Leu Ser Asp Leu Val Phe 
65                  70                  75                  80  


Ala Cys Leu Leu Pro Val Trp Ile Ser Pro Tyr His Trp Gly Trp Val 
                85                  90                  95      


Leu Gly Asp Phe Leu Cys Lys Leu Leu Asn Met Ile Phe Ser Ile Ser 
            100                 105                 110         


Leu Tyr Ser Ser Ile Phe Phe Leu Thr Ile Met Thr Ile His Arg Tyr 
        115                 120                 125             


Leu Ser Val Val Ser Pro Leu Ser Thr Leu Arg Val Pro Thr Leu Arg 
    130                 135                 140                 


Cys Arg Val Leu Val Thr Met Ala Val Trp Val Ala Ser Ile Leu Ser 
145                 150                 155                 160 


Ser Ile Leu Asp Thr Ile Phe His Lys Val Leu Ser Ser Gly Cys Asp 
                165                 170                 175     


Tyr Ser Glu Leu Thr Trp Tyr Leu Thr Ser Val Tyr Gln His Asn Leu 
            180                 185                 190         


Phe Phe Leu Leu Ser Leu Gly Ile Ile Leu Phe Cys Tyr Val Glu Ile 
        195                 200                 205             


Leu Arg Thr Leu Phe Arg Ser Arg Ser Lys Arg Arg His Arg Thr Val 
    210                 215                 220                 


Lys Leu Ile Phe Ala Ile Val Val Ala Tyr Phe Leu Ser Trp Gly Pro 
225                 230                 235                 240 


Tyr Asn Phe Thr Leu Phe Leu Gln Thr Leu Phe Arg Thr Gln Ile Ile 
                245                 250                 255     


Arg Ser Cys Glu Ala Lys Gln Gln Leu Glu Tyr Ala Leu Leu Ile Cys 
            260                 265                 270         


Arg Asn Leu Ala Phe Ser His Cys Cys Phe Asn Pro Val Leu Tyr Val 
        275                 280                 285             


Phe Val Gly Val Lys Phe Arg Thr His Leu Lys His Val Leu Arg Gln 
    290                 295                 300                 


Phe Trp Phe Cys Arg Leu Gln Ala Pro Ser Pro Ala Ser Ile Pro His 
305                 310                 315                 320 


Ser Pro Gly Ala Phe Ala Tyr Glu Gly Ala Ser Phe Tyr 
                325                 330             


<210>  3252
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  3252

Met Asn Ala Ser Ala Ala Ser Leu Asn Asp Ser Gln Val Val Val Val 
1               5                   10                  15      


Ala Ala Glu Gly Ala Ala Ala Ala Ala Thr Ala Ala Gly Gly Pro Asp 
            20                  25                  30          


Thr Gly Glu Trp Gly Pro Pro Ala Ala Ala Ala Leu Gly Ala Gly Gly 
        35                  40                  45              


Gly Ala Asn Gly Ser Leu Glu Leu Ser Ser Gln Leu Ser Ala Gly Pro 
    50                  55                  60                  


Pro Gly Leu Leu Leu Pro Ala Val Asn Pro Trp Asp Val Leu Leu Cys 
65                  70                  75                  80  


Val Ser Gly Thr Val Ile Ala Gly Glu Asn Ala Leu Val Val Ala Leu 
                85                  90                  95      


Ile Ala Ser Thr Pro Ala Leu Arg Thr Pro Met Phe Val Leu Val Gly 
            100                 105                 110         


Ser Leu Ala Thr Ala Asp Leu Leu Ala Gly Cys Gly Leu Ile Leu His 
        115                 120                 125             


Phe Val Phe Gln Tyr Leu Val Pro Ser Glu Thr Val Ser Leu Leu Thr 
    130                 135                 140                 


Val Gly Phe Leu Val Ala Ser Phe Ala Ala Ser Val Ser Ser Leu Leu 
145                 150                 155                 160 


Ala Ile Thr Val Asp Arg Tyr Leu Ser Leu Tyr Asn Ala Leu Thr Tyr 
                165                 170                 175     


Tyr Ser Arg Arg Thr Leu Leu Gly Val His Leu Leu Leu Ala Ala Thr 
            180                 185                 190         


Trp Thr Val Ser Leu Gly Leu Gly Leu Leu Pro Val Leu Gly Trp Asn 
        195                 200                 205             


Cys Leu Ala Glu Arg Ala Ala Cys Ser Val Val Arg Pro Leu Ala Arg 
    210                 215                 220                 


Ser His Val Ala Leu Leu Ser Ala Ala Phe Phe Met Val Phe Gly Ile 
225                 230                 235                 240 


Met Leu His Leu Tyr Val Arg Ile Cys Gln Val Val Trp Arg His Ala 
                245                 250                 255     


His Gln Ile Ala Leu Gln Gln His Cys Leu Ala Pro Pro His Leu Ala 
            260                 265                 270         


Ala Thr Arg Lys Gly Val Gly Thr Leu Ala Val Val Leu Gly Thr Phe 
        275                 280                 285             


Gly Ala Ser Trp Leu Pro Phe Ala Ile Tyr Cys Val Val Gly Ser His 
    290                 295                 300                 


Glu Asp Pro Ala Val Tyr Thr Tyr Ala Thr Leu Leu Pro Ala Thr Tyr 
305                 310                 315                 320 


Asn Ser Met Ile Asn Pro Ile Ile Tyr Ala Phe Arg Asn Gln Glu Ile 
                325                 330                 335     


Gln Arg Ala Leu Trp Leu Leu Leu Cys Gly Cys Phe Gln Ser Lys Val 
            340                 345                 350         


Pro Phe Arg Ser Arg Ser Pro Ser Glu Val 
        355                 360         


<210>  3253
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  3253

Met Asp Asn Ala Ser Phe Ser Glu Pro Trp Pro Ala Asn Ala Ser Gly 
1               5                   10                  15      


Pro Asp Pro Ala Leu Ser Cys Ser Asn Ala Ser Thr Leu Ala Pro Leu 
            20                  25                  30          


Pro Ala Pro Leu Ala Val Ala Val Pro Val Val Tyr Ala Val Ile Cys 
        35                  40                  45              


Ala Val Gly Leu Ala Gly Asn Ser Ala Val Leu Tyr Val Leu Leu Arg 
    50                  55                  60                  


Ala Pro Arg Met Lys Thr Val Thr Asn Leu Phe Ile Leu Asn Leu Ala 
65                  70                  75                  80  


Ile Ala Asp Glu Leu Phe Thr Leu Val Leu Pro Ile Asn Ile Ala Asp 
                85                  90                  95      


Phe Leu Leu Arg Gln Trp Pro Phe Gly Glu Leu Met Cys Lys Leu Ile 
            100                 105                 110         


Val Ala Ile Asp Gln Tyr Asn Thr Phe Ser Ser Leu Tyr Phe Leu Thr 
        115                 120                 125             


Val Met Ser Ala Asp Arg Tyr Leu Val Val Leu Ala Thr Ala Glu Ser 
    130                 135                 140                 


Arg Arg Val Ala Gly Arg Thr Tyr Ser Ala Ala Arg Ala Val Ser Leu 
145                 150                 155                 160 


Ala Val Trp Gly Ile Val Thr Leu Val Val Leu Pro Phe Ala Val Phe 
                165                 170                 175     


Ala Arg Leu Asp Asp Glu Gln Gly Arg Arg Gln Cys Val Leu Val Phe 
            180                 185                 190         


Pro Gln Pro Glu Ala Phe Trp Trp Arg Ala Ser Arg Leu Tyr Thr Leu 
        195                 200                 205             


Val Leu Gly Phe Ala Ile Pro Val Ser Thr Ile Cys Val Leu Tyr Thr 
    210                 215                 220                 


Thr Leu Leu Cys Arg Leu His Ala Met Arg Leu Asp Ser His Ala Lys 
225                 230                 235                 240 


Ala Leu Glu Arg Ala Lys Lys Arg Val Thr Phe Leu Val Val Ala Ile 
                245                 250                 255     


Leu Ala Val Cys Leu Leu Cys Trp Thr Pro Tyr His Leu Ser Thr Val 
            260                 265                 270         


Val Ala Leu Thr Thr Asp Leu Pro Gln Thr Pro Leu Val Ile Ala Ile 
        275                 280                 285             


Ser Tyr Phe Ile Thr Ser Leu Ser Tyr Ala Asn Ser Cys Leu Asn Pro 
    290                 295                 300                 


Phe Leu Tyr Ala Phe Leu Asp Ala Ser Phe Arg Arg Asn Leu Arg Gln 
305                 310                 315                 320 


Leu Ile Thr Cys Arg Ala Ala Ala 
                325             


<210>  3254
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  3254

Met Gln Ala Ala Gly His Pro Glu Pro Leu Asp Ser Arg Gly Ser Phe 
1               5                   10                  15      


Ser Leu Pro Thr Met Gly Ala Asn Val Ser Gln Asp Asn Gly Thr Gly 
            20                  25                  30          


His Asn Ala Thr Phe Ser Glu Pro Leu Pro Phe Leu Tyr Val Leu Leu 
        35                  40                  45              


Pro Ala Val Tyr Ser Gly Ile Cys Ala Val Gly Leu Thr Gly Asn Thr 
    50                  55                  60                  


Ala Val Ile Leu Val Ile Leu Arg Ala Pro Lys Met Lys Thr Val Thr 
65                  70                  75                  80  


Asn Val Phe Ile Leu Asn Leu Ala Val Ala Asp Gly Leu Phe Thr Leu 
                85                  90                  95      


Val Leu Pro Val Asn Ile Ala Glu His Leu Leu Gln Tyr Trp Pro Phe 
            100                 105                 110         


Gly Glu Leu Leu Cys Lys Leu Val Leu Ala Val Asp His Tyr Asn Ile 
        115                 120                 125             


Phe Ser Ser Ile Tyr Phe Leu Ala Val Met Ser Val Asp Arg Tyr Leu 
    130                 135                 140                 


Val Val Leu Ala Thr Val Arg Ser Arg His Met Pro Trp Arg Thr Tyr 
145                 150                 155                 160 


Arg Gly Ala Lys Val Ala Ser Leu Cys Val Trp Leu Gly Val Thr Val 
                165                 170                 175     


Leu Val Leu Pro Phe Phe Ser Phe Ala Gly Val Tyr Ser Asn Glu Leu 
            180                 185                 190         


Gln Val Pro Ser Cys Gly Leu Ser Phe Pro Trp Pro Glu Gln Val Trp 
        195                 200                 205             


Phe Lys Ala Ser Arg Val Tyr Thr Leu Val Leu Gly Phe Val Leu Pro 
    210                 215                 220                 


Val Cys Thr Ile Cys Val Leu Tyr Thr Asp Leu Leu Arg Arg Leu Arg 
225                 230                 235                 240 


Ala Val Arg Leu Arg Ser Gly Ala Lys Ala Leu Gly Lys Ala Arg Arg 
                245                 250                 255     


Lys Val Thr Val Leu Val Leu Val Val Leu Ala Val Cys Leu Leu Cys 
            260                 265                 270         


Trp Thr Pro Phe His Leu Ala Ser Val Val Ala Leu Thr Thr Asp Leu 
        275                 280                 285             


Pro Gln Thr Pro Leu Val Ile Ser Met Ser Tyr Val Ile Thr Ser Leu 
    290                 295                 300                 


Ser Tyr Ala Asn Ser Cys Leu Asn Pro Phe Leu Tyr Ala Phe Leu Asp 
305                 310                 315                 320 


Asp Asn Phe Arg Lys Asn Phe Arg Ser Ile Leu Arg Cys 
                325                 330             


<210>  3255
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  3255

Met Asn Glu Asp Leu Lys Val Asn Leu Ser Gly Leu Pro Arg Asp Tyr 
1               5                   10                  15      


Leu Asp Ala Ala Ala Ala Glu Asn Ile Ser Ala Ala Val Ser Ser Arg 
            20                  25                  30          


Val Pro Ala Val Glu Pro Glu Pro Glu Leu Val Val Asn Pro Trp Asp 
        35                  40                  45              


Ile Val Leu Cys Thr Ser Gly Thr Leu Ile Ser Cys Glu Asn Ala Ile 
    50                  55                  60                  


Val Val Leu Ile Ile Phe His Asn Pro Ser Leu Arg Ala Pro Met Phe 
65                  70                  75                  80  


Leu Leu Ile Gly Ser Leu Ala Leu Ala Asp Leu Leu Ala Gly Ile Gly 
                85                  90                  95      


Leu Ile Thr Asn Phe Val Phe Ala Tyr Leu Leu Gln Ser Glu Ala Thr 
            100                 105                 110         


Lys Leu Val Thr Ile Gly Leu Ile Val Ala Ser Phe Ser Ala Ser Val 
        115                 120                 125             


Cys Ser Leu Leu Ala Ile Thr Val Asp Arg Tyr Leu Ser Leu Tyr Tyr 
    130                 135                 140                 


Ala Leu Thr Tyr His Ser Glu Arg Thr Val Thr Phe Thr Tyr Val Met 
145                 150                 155                 160 


Leu Val Met Leu Trp Gly Thr Ser Ile Cys Leu Gly Leu Leu Pro Val 
                165                 170                 175     


Met Gly Trp Asn Cys Leu Arg Asp Glu Ser Thr Cys Ser Val Val Arg 
            180                 185                 190         


Pro Leu Thr Lys Asn Asn Ala Ala Ile Leu Ser Val Ser Phe Leu Phe 
        195                 200                 205             


Met Phe Ala Leu Met Leu Gln Leu Tyr Ile Gln Ile Cys Lys Ile Val 
    210                 215                 220                 


Met Arg His Ala His Gln Ile Ala Leu Gln His His Phe Leu Ala Thr 
225                 230                 235                 240 


Ser His Tyr Val Thr Thr Arg Lys Gly Val Ser Thr Leu Ala Ile Ile 
                245                 250                 255     


Leu Gly Thr Phe Ala Ala Cys Trp Met Pro Phe Thr Leu Tyr Ser Leu 
            260                 265                 270         


Ile Ala Asp Tyr Thr Tyr Pro Ser Ile Tyr Thr Tyr Ala Thr Leu Leu 
        275                 280                 285             


Pro Ala Thr Tyr Asn Ser Ile Ile Asn Pro Val Ile Tyr Ala Phe Arg 
    290                 295                 300                 


Asn Gln Glu Ile Gln Lys Ala Leu Cys Leu Ile Cys Cys Gly Cys Ile 
305                 310                 315                 320 


Pro Ser Ser Leu Ala Gln Arg Ala Arg Ser Pro Ser Asp Val 
                325                 330                 


<210>  3256
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  3256

Met Asp Pro Glu Glu Thr Ser Val Tyr Leu Asp Tyr Tyr Tyr Ala Thr 
1               5                   10                  15      


Ser Pro Asn Ser Asp Ile Arg Glu Thr His Ser His Val Pro Tyr Thr 
            20                  25                  30          


Ser Val Phe Leu Pro Val Phe Tyr Thr Ala Val Phe Leu Thr Gly Val 
        35                  40                  45              


Leu Gly Asn Leu Val Leu Met Gly Ala Leu His Phe Lys Pro Gly Ser 
    50                  55                  60                  


Arg Arg Leu Ile Asp Ile Phe Ile Ile Asn Leu Ala Ala Ser Asp Phe 
65                  70                  75                  80  


Ile Phe Leu Val Thr Leu Pro Leu Trp Val Asp Lys Glu Ala Ser Leu 
                85                  90                  95      


Gly Leu Trp Arg Thr Gly Ser Phe Leu Cys Lys Gly Ser Ser Tyr Met 
            100                 105                 110         


Ile Ser Val Asn Met His Cys Ser Val Leu Leu Leu Thr Cys Met Ser 
        115                 120                 125             


Val Asp Arg Tyr Leu Ala Ile Val Trp Pro Val Val Ser Arg Lys Phe 
    130                 135                 140                 


Arg Arg Thr Asp Cys Ala Tyr Val Val Cys Ala Ser Ile Trp Phe Ile 
145                 150                 155                 160 


Ser Cys Leu Leu Gly Leu Pro Thr Leu Leu Ser Arg Glu Leu Thr Leu 
                165                 170                 175     


Ile Asp Asp Lys Pro Tyr Cys Ala Glu Lys Lys Ala Thr Pro Ile Lys 
            180                 185                 190         


Leu Ile Trp Ser Leu Val Ala Leu Ile Phe Thr Phe Phe Val Pro Leu 
        195                 200                 205             


Leu Ser Ile Val Thr Cys Tyr Cys Cys Ile Ala Arg Lys Leu Cys Ala 
    210                 215                 220                 


His Tyr Gln Gln Ser Gly Lys His Asn Lys Lys Leu Lys Lys Ser Ile 
225                 230                 235                 240 


Lys Ile Ile Phe Ile Val Val Ala Ala Phe Leu Val Ser Trp Leu Pro 
                245                 250                 255     


Phe Asn Thr Phe Lys Phe Leu Ala Ile Val Ser Gly Leu Arg Gln Glu 
            260                 265                 270         


His Tyr Leu Pro Ser Ala Ile Leu Gln Leu Gly Met Glu Val Ser Gly 
        275                 280                 285             


Pro Leu Ala Phe Ala Asn Ser Cys Val Asn Pro Phe Ile Tyr Tyr Ile 
    290                 295                 300                 


Phe Asp Ser Tyr Ile Arg Arg Ala Ile Val His Cys Leu Cys Pro Cys 
305                 310                 315                 320 


Leu Lys Asn Tyr Asp Phe Gly Ser Ser Thr Glu Thr Ser Asp Ser His 
                325                 330                 335     


Leu Thr Lys Ala Leu Ser Thr Phe Ile His Ala Glu Asp Phe Ala Arg 
            340                 345                 350         


Arg Arg Lys Arg Ser Val Ser Leu 
        355                 360 


<210>  3257
<211>  367
<212>  PRT
<213>  Homo sapiens

<400>  3257

Met Ser Lys Arg Ser Trp Trp Ala Gly Ser Arg Lys Pro Pro Arg Glu 
1               5                   10                  15      


Met Leu Lys Leu Ser Gly Ser Asp Ser Ser Gln Ser Met Asn Gly Leu 
            20                  25                  30          


Glu Val Ala Pro Pro Gly Leu Ile Thr Asn Phe Ser Leu Ala Thr Ala 
        35                  40                  45              


Glu Gln Cys Gly Gln Glu Thr Pro Leu Glu Asn Met Leu Phe Ala Ser 
    50                  55                  60                  


Phe Tyr Leu Leu Asp Phe Ile Leu Ala Leu Val Gly Asn Thr Leu Ala 
65                  70                  75                  80  


Leu Trp Leu Phe Ile Arg Asp His Lys Ser Gly Thr Pro Ala Asn Val 
                85                  90                  95      


Phe Leu Met His Leu Ala Val Ala Asp Leu Ser Cys Val Leu Val Leu 
            100                 105                 110         


Pro Thr Arg Leu Val Tyr His Phe Ser Gly Asn His Trp Pro Phe Gly 
        115                 120                 125             


Glu Ile Ala Cys Arg Leu Thr Gly Phe Leu Phe Tyr Leu Asn Met Tyr 
    130                 135                 140                 


Ala Ser Ile Tyr Phe Leu Thr Cys Ile Ser Ala Asp Arg Phe Leu Ala 
145                 150                 155                 160 


Ile Val His Pro Val Lys Ser Leu Lys Leu Arg Arg Pro Leu Tyr Ala 
                165                 170                 175     


His Leu Ala Cys Ala Phe Leu Trp Val Val Val Ala Val Ala Met Ala 
            180                 185                 190         


Pro Leu Leu Val Ser Pro Gln Thr Val Gln Thr Asn His Thr Val Val 
        195                 200                 205             


Cys Leu Gln Leu Tyr Arg Glu Lys Ala Ser His His Ala Leu Val Ser 
    210                 215                 220                 


Leu Ala Val Ala Phe Thr Phe Pro Phe Ile Thr Thr Val Thr Cys Tyr 
225                 230                 235                 240 


Leu Leu Ile Ile Arg Ser Leu Arg Gln Gly Leu Arg Val Glu Lys Arg 
                245                 250                 255     


Leu Lys Thr Lys Ala Val Arg Met Ile Ala Ile Val Leu Ala Ile Phe 
            260                 265                 270         


Leu Val Cys Phe Val Pro Tyr His Val Asn Arg Ser Val Tyr Val Leu 
        275                 280                 285             


His Tyr Arg Ser His Gly Ala Ser Cys Ala Thr Gln Arg Ile Leu Ala 
    290                 295                 300                 


Leu Ala Asn Arg Ile Thr Ser Cys Leu Thr Ser Leu Asn Gly Ala Leu 
305                 310                 315                 320 


Asp Pro Ile Met Tyr Phe Phe Val Ala Glu Lys Phe Arg His Ala Leu 
                325                 330                 335     


Cys Asn Leu Leu Cys Gly Lys Arg Leu Lys Gly Pro Pro Pro Ser Phe 
            340                 345                 350         


Glu Gly Lys Thr Asn Glu Ser Ser Leu Ser Ala Lys Ser Glu Leu 
        355                 360                 365         


<210>  3258
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  3258

Met Ile Thr Leu Asn Asn Gln Asp Gln Pro Val Pro Phe Asn Ser Ser 
1               5                   10                  15      


His Pro Asp Glu Tyr Lys Ile Ala Ala Leu Val Phe Tyr Ser Cys Ile 
            20                  25                  30          


Phe Ile Ile Gly Leu Phe Val Asn Ile Thr Ala Leu Trp Val Phe Ser 
        35                  40                  45              


Cys Thr Thr Lys Lys Arg Thr Thr Val Thr Ile Tyr Met Met Asn Val 
    50                  55                  60                  


Ala Leu Val Asp Leu Ile Phe Ile Met Thr Leu Pro Phe Arg Met Phe 
65                  70                  75                  80  


Tyr Tyr Ala Lys Asp Glu Trp Pro Phe Gly Glu Tyr Phe Cys Gln Ile 
                85                  90                  95      


Leu Gly Ala Leu Thr Val Phe Tyr Pro Ser Ile Ala Leu Trp Leu Leu 
            100                 105                 110         


Ala Phe Ile Ser Ala Asp Arg Tyr Met Ala Ile Val Gln Pro Lys Tyr 
        115                 120                 125             


Ala Lys Glu Leu Lys Asn Thr Cys Lys Ala Val Leu Ala Cys Val Gly 
    130                 135                 140                 


Val Trp Ile Met Thr Leu Thr Thr Thr Thr Pro Leu Leu Leu Leu Tyr 
145                 150                 155                 160 


Lys Asp Pro Asp Lys Asp Ser Thr Pro Ala Thr Cys Leu Lys Ile Ser 
                165                 170                 175     


Asp Ile Ile Tyr Leu Lys Ala Val Asn Val Leu Asn Leu Thr Arg Leu 
            180                 185                 190         


Thr Phe Phe Phe Leu Ile Pro Leu Phe Ile Met Ile Gly Cys Tyr Leu 
        195                 200                 205             


Val Ile Ile His Asn Leu Leu His Gly Arg Thr Ser Lys Leu Lys Pro 
    210                 215                 220                 


Lys Val Lys Glu Lys Ser Ile Arg Ile Ile Ile Thr Leu Leu Val Gln 
225                 230                 235                 240 


Val Leu Val Cys Phe Met Pro Phe His Ile Cys Phe Ala Phe Leu Met 
                245                 250                 255     


Leu Gly Thr Gly Glu Asn Ser Tyr Asn Pro Trp Gly Ala Phe Thr Thr 
            260                 265                 270         


Phe Leu Met Asn Leu Ser Thr Cys Leu Asp Val Ile Leu Tyr Tyr Ile 
        275                 280                 285             


Val Ser Lys Gln Phe Gln Ala Arg Val Ile Ser Val Met Leu Tyr Arg 
    290                 295                 300                 


Asn Tyr Leu Arg Ser Met Arg Arg Lys Ser Phe Arg Ser Gly Ser Leu 
305                 310                 315                 320 


Arg Ser Leu Ser Asn Ile Asn Ser Glu Met Leu 
                325                 330     


<210>  3259
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  3259

Met Pro Ser Val Ser Pro Ala Gly Pro Ser Ala Gly Ala Val Pro Asn 
1               5                   10                  15      


Ala Thr Ala Val Thr Thr Val Arg Thr Asn Ala Ser Gly Leu Glu Val 
            20                  25                  30          


Pro Leu Phe His Leu Phe Ala Arg Leu Asp Glu Glu Leu His Gly Thr 
        35                  40                  45              


Phe Pro Gly Leu Trp Leu Ala Leu Met Ala Val His Gly Ala Ile Phe 
    50                  55                  60                  


Leu Ala Gly Leu Val Leu Asn Gly Leu Ala Leu Tyr Val Phe Cys Cys 
65                  70                  75                  80  


Arg Thr Arg Ala Lys Thr Pro Ser Val Ile Tyr Thr Ile Asn Leu Val 
                85                  90                  95      


Val Thr Asp Leu Leu Val Gly Leu Ser Leu Pro Thr Arg Phe Ala Val 
            100                 105                 110         


Tyr Tyr Gly Ala Arg Gly Cys Leu Arg Cys Ala Phe Pro His Val Leu 
        115                 120                 125             


Gly Tyr Phe Leu Asn Met His Cys Ser Ile Leu Phe Leu Thr Cys Ile 
    130                 135                 140                 


Cys Val Asp Arg Tyr Leu Ala Ile Val Arg Pro Glu Gly Ser Arg Arg 
145                 150                 155                 160 


Cys Arg Gln Pro Ala Cys Ala Arg Ala Val Cys Ala Phe Val Trp Leu 
                165                 170                 175     


Ala Ala Gly Ala Val Thr Leu Ser Val Leu Gly Val Thr Gly Ser Arg 
            180                 185                 190         


Pro Cys Cys Arg Val Phe Ala Leu Thr Val Leu Glu Phe Leu Leu Pro 
        195                 200                 205             


Leu Leu Val Ile Ser Val Phe Thr Gly Arg Ile Met Cys Ala Leu Ser 
    210                 215                 220                 


Arg Pro Gly Leu Leu His Gln Gly Arg Gln Arg Arg Val Arg Ala Met 
225                 230                 235                 240 


Gln Leu Leu Leu Thr Val Leu Ile Ile Phe Leu Val Cys Phe Thr Pro 
                245                 250                 255     


Phe His Ala Arg Gln Val Ala Val Ala Leu Trp Pro Asp Met Pro His 
            260                 265                 270         


His Thr Ser Leu Val Val Tyr His Val Ala Val Thr Leu Ser Ser Leu 
        275                 280                 285             


Asn Ser Cys Met Asp Pro Ile Val Tyr Cys Phe Val Thr Ser Gly Phe 
    290                 295                 300                 


Gln Ala Thr Val Arg Gly Leu Phe Gly Gln His Gly Glu Arg Glu Pro 
305                 310                 315                 320 


Ser Ser Gly Asp Val Val Ser Met His Arg Ser Ser Lys Gly Ser Gly 
                325                 330                 335     


Arg His His Ile Leu Ser Ala Gly Pro His Ala Leu Thr Gln Ala Leu 
            340                 345                 350         


Ala Asn Gly Pro Glu Ala 
        355             


<210>  3260
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  3260

Met Asn Ser Thr Leu Asp Gly Asn Gln Ser Ser His Pro Phe Cys Leu 
1               5                   10                  15      


Leu Ala Phe Gly Tyr Leu Glu Thr Val Asn Phe Cys Leu Leu Glu Val 
            20                  25                  30          


Leu Ile Ile Val Phe Leu Thr Val Leu Ile Ile Ser Gly Asn Ile Ile 
        35                  40                  45              


Val Ile Phe Val Phe His Cys Ala Pro Leu Leu Asn His His Thr Thr 
    50                  55                  60                  


Ser Tyr Phe Ile Gln Thr Met Ala Tyr Ala Asp Leu Phe Val Gly Val 
65                  70                  75                  80  


Ser Cys Val Val Pro Ser Leu Ser Leu Leu His His Pro Leu Pro Val 
                85                  90                  95      


Glu Glu Ser Leu Thr Cys Gln Ile Phe Gly Phe Val Val Ser Val Leu 
            100                 105                 110         


Lys Ser Val Ser Met Ala Ser Leu Ala Cys Ile Ser Ile Asp Arg Tyr 
        115                 120                 125             


Ile Ala Ile Thr Lys Pro Leu Thr Tyr Asn Thr Leu Val Thr Pro Trp 
    130                 135                 140                 


Arg Leu Arg Leu Cys Ile Phe Leu Ile Trp Leu Tyr Ser Thr Leu Val 
145                 150                 155                 160 


Phe Leu Pro Ser Phe Phe His Trp Gly Lys Pro Gly Tyr His Gly Asp 
                165                 170                 175     


Val Phe Gln Trp Cys Ala Glu Ser Trp His Thr Asp Ser Tyr Phe Thr 
            180                 185                 190         


Leu Phe Ile Val Met Met Leu Tyr Ala Pro Ala Ala Leu Ile Val Cys 
        195                 200                 205             


Phe Thr Tyr Phe Asn Ile Phe Arg Ile Cys Gln Gln His Thr Lys Asp 
    210                 215                 220                 


Ile Ser Glu Arg Gln Ala Arg Phe Ser Ser Gln Ser Gly Glu Thr Gly 
225                 230                 235                 240 


Glu Val Gln Ala Cys Pro Asp Lys Arg Tyr Ala Met Val Leu Phe Arg 
                245                 250                 255     


Ile Thr Ser Val Phe Tyr Ile Leu Trp Leu Pro Tyr Ile Ile Tyr Phe 
            260                 265                 270         


Leu Leu Glu Ser Ser Thr Gly His Ser Asn Arg Phe Ala Ser Phe Leu 
        275                 280                 285             


Thr Thr Trp Leu Ala Ile Ser Asn Ser Phe Cys Asn Cys Val Ile Tyr 
    290                 295                 300                 


Ser Leu Ser Asn Ser Val Phe Gln Arg Gly Leu Lys Arg Leu Ser Gly 
305                 310                 315                 320 


Ala Met Cys Thr Ser Cys Ala Ser Gln Thr Thr Ala Asn Asp Pro Tyr 
                325                 330                 335     


Thr Val Arg Ser Lys Gly Pro Leu Asn Gly Cys His Ile 
            340                 345                 


<210>  3261
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  3261

Met Cys Phe Ser Pro Ile Leu Glu Ile Asn Met Gln Ser Glu Ser Asn 
1               5                   10                  15      


Ile Thr Val Arg Asp Asp Ile Asp Asp Ile Asn Thr Asn Met Tyr Gln 
            20                  25                  30          


Pro Leu Ser Tyr Pro Leu Ser Phe Gln Val Ser Leu Thr Gly Phe Leu 
        35                  40                  45              


Met Leu Glu Ile Val Leu Gly Leu Gly Ser Asn Leu Thr Val Leu Val 
    50                  55                  60                  


Leu Tyr Cys Met Lys Ser Asn Leu Ile Asn Ser Val Ser Asn Ile Ile 
65                  70                  75                  80  


Thr Met Asn Leu His Val Leu Asp Val Ile Ile Cys Val Gly Cys Ile 
                85                  90                  95      


Pro Leu Thr Ile Val Ile Leu Leu Leu Ser Leu Glu Ser Asn Thr Ala 
            100                 105                 110         


Leu Ile Cys Cys Phe His Glu Ala Cys Val Ser Phe Ala Ser Val Ser 
        115                 120                 125             


Thr Ala Ile Asn Val Phe Ala Ile Thr Leu Asp Arg Tyr Asp Ile Ser 
    130                 135                 140                 


Val Lys Pro Ala Asn Arg Ile Leu Thr Met Gly Arg Ala Val Met Leu 
145                 150                 155                 160 


Met Ile Ser Ile Trp Ile Phe Ser Phe Phe Ser Phe Leu Ile Pro Phe 
                165                 170                 175     


Ile Glu Val Asn Phe Phe Ser Leu Gln Ser Gly Asn Thr Trp Glu Asn 
            180                 185                 190         


Lys Thr Leu Leu Cys Val Ser Thr Asn Glu Tyr Tyr Thr Glu Leu Gly 
        195                 200                 205             


Met Tyr Tyr His Leu Leu Val Gln Ile Pro Ile Phe Phe Phe Thr Val 
    210                 215                 220                 


Val Val Met Leu Ile Thr Tyr Thr Lys Ile Leu Gln Ala Leu Asn Ile 
225                 230                 235                 240 


Arg Ile Gly Thr Arg Phe Ser Thr Gly Gln Lys Lys Lys Ala Arg Lys 
                245                 250                 255     


Lys Lys Thr Ile Ser Leu Thr Thr Gln His Glu Ala Thr Asp Met Ser 
            260                 265                 270         


Gln Ser Ser Gly Gly Arg Asn Val Val Phe Gly Val Arg Thr Ser Val 
        275                 280                 285             


Ser Val Ile Ile Ala Leu Arg Arg Ala Val Lys Arg His Arg Glu Arg 
    290                 295                 300                 


Arg Glu Arg Gln Lys Arg Val Phe Arg Met Ser Leu Leu Ile Ile Ser 
305                 310                 315                 320 


Thr Phe Leu Leu Cys Trp Thr Pro Ile Ser Val Leu Asn Thr Thr Ile 
                325                 330                 335     


Leu Cys Leu Gly Pro Ser Asp Leu Leu Val Lys Leu Arg Leu Cys Phe 
            340                 345                 350         


Leu Val Met Ala Tyr Gly Thr Thr Ile Phe His Pro Leu Leu Tyr Ala 
        355                 360                 365             


Phe Thr Arg Gln Lys Phe Gln Lys Val Leu Lys Ser Lys Met Lys Lys 
    370                 375                 380                 


Arg Val Val Ser Ile Val Glu Ala Asp Pro Leu Pro Asn Asn Ala Val 
385                 390                 395                 400 


Ile His Asn Ser Trp Ile Asp Pro Lys Arg Asn Lys Lys Ile Thr Phe 
                405                 410                 415     


Glu Asp Ser Glu Ile Arg Glu Lys Cys Leu Val Pro Gln Val Val Thr 
            420                 425                 430         


Asp 
    


<210>  3262
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  3262

Met Gly Asp Arg Arg Phe Ile Asp Phe Gln Phe Gln Asp Ser Asn Ser 
1               5                   10                  15      


Ser Leu Arg Pro Arg Leu Gly Asn Ala Thr Ala Asn Asn Thr Cys Ile 
            20                  25                  30          


Val Asp Asp Ser Phe Lys Tyr Asn Leu Asn Gly Ala Val Tyr Ser Val 
        35                  40                  45              


Val Phe Ile Leu Gly Leu Ile Thr Asn Ser Val Ser Leu Phe Val Phe 
    50                  55                  60                  


Cys Phe Arg Met Lys Met Arg Ser Glu Thr Ala Ile Phe Ile Thr Asn 
65                  70                  75                  80  


Leu Ala Val Ser Asp Leu Leu Phe Val Cys Thr Leu Pro Phe Lys Ile 
                85                  90                  95      


Phe Tyr Asn Phe Asn Arg His Trp Pro Phe Gly Asp Thr Leu Cys Lys 
            100                 105                 110         


Ile Ser Gly Thr Ala Phe Leu Thr Asn Ile Tyr Gly Ser Met Leu Phe 
        115                 120                 125             


Leu Thr Cys Ile Ser Val Asp Arg Phe Leu Ala Ile Val Tyr Pro Phe 
    130                 135                 140                 


Arg Ser Arg Thr Ile Arg Thr Arg Arg Asn Ser Ala Ile Val Cys Ala 
145                 150                 155                 160 


Gly Val Trp Ile Leu Val Leu Ser Gly Gly Ile Ser Ala Ser Leu Phe 
                165                 170                 175     


Ser Thr Thr Asn Val Asn Asn Ala Thr Thr Thr Cys Phe Glu Gly Phe 
            180                 185                 190         


Ser Lys Arg Val Trp Lys Thr Tyr Leu Ser Lys Ile Thr Ile Phe Ile 
        195                 200                 205             


Glu Val Val Gly Phe Ile Ile Pro Leu Ile Leu Asn Val Ser Cys Ser 
    210                 215                 220                 


Ser Val Val Leu Arg Thr Leu Arg Lys Pro Ala Thr Leu Ser Gln Ile 
225                 230                 235                 240 


Gly Thr Asn Lys Lys Lys Val Leu Lys Met Ile Thr Val His Met Ala 
                245                 250                 255     


Val Phe Val Val Cys Phe Val Pro Tyr Asn Ser Val Leu Phe Leu Tyr 
            260                 265                 270         


Ala Leu Val Arg Ser Gln Ala Ile Thr Asn Cys Phe Leu Glu Arg Phe 
        275                 280                 285             


Ala Lys Ile Met Tyr Pro Ile Thr Leu Cys Leu Ala Thr Leu Asn Cys 
    290                 295                 300                 


Cys Phe Asp Pro Phe Ile Tyr Tyr Phe Thr Leu Glu Ser Phe Gln Lys 
305                 310                 315                 320 


Ser Phe Tyr Ile Asn Ala His Ile Arg Met Glu Ser Leu Phe Lys Thr 
                325                 330                 335     


Glu Thr Pro Leu Thr Thr Lys Pro Ser Leu Pro Ala Ile Gln Glu Glu 
            340                 345                 350         


Val Ser Asp Gln Thr Thr Asn Asn Gly Gly Glu Leu Met Leu Glu Ser 
        355                 360                 365             


Thr Phe 
    370 


<210>  3263
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  3263

Met Ser Val Gly Ala Met Lys Lys Gly Val Gly Arg Ala Val Gly Leu 
1               5                   10                  15      


Gly Gly Gly Ser Gly Cys Gln Ala Thr Glu Glu Asp Pro Leu Pro Asn 
            20                  25                  30          


Cys Gly Ala Cys Ala Pro Gly Gln Gly Gly Arg Arg Trp Arg Leu Pro 
        35                  40                  45              


Gln Pro Ala Trp Val Glu Gly Ser Ser Ala Arg Leu Trp Glu Gln Ala 
    50                  55                  60                  


Thr Gly Thr Gly Trp Met Asp Leu Glu Ala Ser Leu Leu Pro Thr Gly 
65                  70                  75                  80  


Pro Asn Ala Ser Asn Thr Ser Asp Gly Pro Asp Asn Leu Thr Ser Ala 
                85                  90                  95      


Gly Ser Pro Pro Arg Thr Gly Ser Ile Ser Tyr Ile Asn Ile Ile Met 
            100                 105                 110         


Pro Ser Val Phe Gly Thr Ile Cys Leu Leu Gly Ile Ile Gly Asn Ser 
        115                 120                 125             


Thr Val Ile Phe Ala Val Val Lys Lys Ser Lys Leu His Trp Cys Asn 
    130                 135                 140                 


Asn Val Pro Asp Ile Phe Ile Ile Asn Leu Ser Val Val Asp Leu Leu 
145                 150                 155                 160 


Phe Leu Leu Gly Met Pro Phe Met Ile His Gln Leu Met Gly Asn Gly 
                165                 170                 175     


Val Trp His Phe Gly Glu Thr Met Cys Thr Leu Ile Thr Ala Met Asp 
            180                 185                 190         


Ala Asn Ser Gln Phe Thr Ser Thr Tyr Ile Leu Thr Ala Met Ala Ile 
        195                 200                 205             


Asp Arg Tyr Leu Ala Thr Val His Pro Ile Ser Ser Thr Lys Phe Arg 
    210                 215                 220                 


Lys Pro Ser Val Ala Thr Leu Val Ile Cys Leu Leu Trp Ala Leu Ser 
225                 230                 235                 240 


Phe Ile Ser Ile Thr Pro Val Trp Leu Tyr Ala Arg Leu Ile Pro Phe 
                245                 250                 255     


Pro Gly Gly Ala Val Gly Cys Gly Ile Arg Leu Pro Asn Pro Asp Thr 
            260                 265                 270         


Asp Leu Tyr Trp Phe Thr Leu Tyr Gln Phe Phe Leu Ala Phe Ala Leu 
        275                 280                 285             


Pro Phe Val Val Ile Thr Ala Ala Tyr Val Arg Ile Leu Gln Arg Met 
    290                 295                 300                 


Thr Ser Ser Val Ala Pro Ala Ser Gln Arg Ser Ile Arg Leu Arg Thr 
305                 310                 315                 320 


Lys Arg Val Thr Arg Thr Ala Ile Ala Ile Cys Leu Val Phe Phe Val 
                325                 330                 335     


Cys Trp Ala Pro Tyr Tyr Val Leu Gln Leu Thr Gln Leu Ser Ile Ser 
            340                 345                 350         


Arg Pro Thr Leu Thr Phe Val Tyr Leu Tyr Asn Ala Ala Ile Ser Leu 
        355                 360                 365             


Gly Tyr Ala Asn Ser Cys Leu Asn Pro Phe Val Tyr Ile Val Leu Cys 
    370                 375                 380                 


Glu Thr Phe Arg Lys Arg Leu Val Leu Ser Val Lys Pro Ala Ala Gln 
385                 390                 395                 400 


Gly Gln Leu Arg Ala Val Ser Asn Ala Gln Thr Ala Asp Glu Glu Arg 
                405                 410                 415     


Thr Glu Ser Lys Gly Thr 
            420         


<210>  3264
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  3264

Met Ala Pro Thr Glu Pro Trp Ser Pro Ser Pro Gly Ser Ala Pro Trp 
1               5                   10                  15      


Asp Tyr Ser Gly Leu Asp Gly Leu Glu Glu Leu Glu Leu Cys Pro Ala 
            20                  25                  30          


Gly Asp Leu Pro Tyr Gly Tyr Val Tyr Ile Pro Ala Leu Tyr Leu Ala 
        35                  40                  45              


Ala Phe Ala Val Gly Leu Leu Gly Asn Ala Phe Val Val Trp Leu Leu 
    50                  55                  60                  


Ala Gly Arg Arg Gly Pro Arg Arg Leu Val Asp Thr Phe Val Leu His 
65                  70                  75                  80  


Leu Ala Ala Ala Asp Leu Gly Phe Val Leu Thr Leu Pro Leu Trp Ala 
                85                  90                  95      


Ala Ala Ala Ala Leu Gly Gly Arg Trp Pro Phe Gly Asp Gly Leu Cys 
            100                 105                 110         


Lys Leu Ser Ser Phe Ala Leu Ala Gly Thr Arg Cys Ala Gly Ala Leu 
        115                 120                 125             


Leu Leu Ala Gly Met Ser Val Asp Arg Tyr Leu Ala Val Val Lys Leu 
    130                 135                 140                 


Leu Glu Ala Arg Pro Leu Arg Thr Pro Arg Cys Ala Leu Ala Ser Cys 
145                 150                 155                 160 


Cys Gly Val Trp Ala Val Ala Leu Leu Ala Gly Leu Pro Ser Leu Val 
                165                 170                 175     


Tyr Arg Gly Leu Gln Pro Leu Pro Gly Gly Gln Asp Ser Gln Cys Gly 
            180                 185                 190         


Glu Glu Pro Ser His Ala Phe Gln Gly Leu Ser Leu Leu Leu Leu Leu 
        195                 200                 205             


Leu Thr Phe Val Leu Pro Leu Val Val Thr Leu Phe Cys Tyr Cys Arg 
    210                 215                 220                 


Ile Ser Arg Arg Leu Arg Arg Pro Pro His Val Gly Arg Ala Arg Arg 
225                 230                 235                 240 


Asn Ser Leu Arg Ile Ile Phe Ala Ile Glu Ser Thr Phe Val Gly Ser 
                245                 250                 255     


Trp Leu Pro Phe Ser Ala Leu Arg Ala Val Phe His Leu Ala Arg Leu 
            260                 265                 270         


Gly Ala Leu Pro Leu Pro Cys Pro Leu Leu Leu Ala Leu Arg Trp Gly 
        275                 280                 285             


Leu Thr Ile Ala Thr Cys Leu Ala Phe Val Asn Ser Cys Ala Asn Pro 
    290                 295                 300                 


Leu Ile Tyr Leu Leu Leu Asp Arg Ser Phe Arg Ala Arg Ala Leu Asp 
305                 310                 315                 320 


Gly Ala Cys Gly Arg Thr Gly Arg Leu Ala Arg Arg Ile Ser Ser Ala 
                325                 330                 335     


Ser Ser Leu Ser Arg Asp Asp Ser Ser Val Phe Arg Cys Arg Ala Gln 
            340                 345                 350         


Ala Ala Asn Thr Ala Ser Ala Ser Trp 
        355                 360     


<210>  3265
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  3265

Met Pro Phe Pro Asn Cys Ser Ala Pro Ser Thr Val Val Ala Thr Ala 
1               5                   10                  15      


Val Gly Val Leu Leu Gly Leu Glu Cys Gly Leu Gly Leu Leu Gly Asn 
            20                  25                  30          


Ala Val Ala Leu Trp Thr Phe Leu Phe Arg Val Arg Val Trp Lys Pro 
        35                  40                  45              


Tyr Ala Val Tyr Leu Leu Asn Leu Ala Leu Ala Asp Leu Leu Leu Ala 
    50                  55                  60                  


Ala Cys Leu Pro Phe Leu Ala Ala Phe Tyr Leu Ser Leu Gln Ala Trp 
65                  70                  75                  80  


His Leu Gly Arg Val Gly Cys Trp Ala Leu His Phe Leu Leu Asp Leu 
                85                  90                  95      


Ser Arg Ser Val Gly Met Ala Phe Leu Ala Ala Val Ala Leu Asp Arg 
            100                 105                 110         


Tyr Leu Arg Val Val His Pro Arg Leu Lys Val Asn Leu Leu Ser Pro 
        115                 120                 125             


Gln Ala Ala Leu Gly Val Ser Gly Leu Val Trp Leu Leu Met Val Ala 
    130                 135                 140                 


Leu Thr Cys Pro Gly Leu Leu Ile Ser Glu Ala Ala Gln Asn Ser Thr 
145                 150                 155                 160 


Arg Cys His Ser Phe Tyr Ser Arg Ala Asp Gly Ser Phe Ser Ile Ile 
                165                 170                 175     


Trp Gln Glu Ala Leu Ser Cys Leu Gln Phe Val Leu Pro Phe Gly Leu 
            180                 185                 190         


Ile Val Phe Cys Asn Ala Gly Ile Ile Arg Ala Leu Gln Lys Arg Leu 
        195                 200                 205             


Arg Glu Pro Glu Lys Gln Pro Lys Leu Gln Arg Ala Gln Ala Leu Val 
    210                 215                 220                 


Thr Leu Val Val Val Leu Phe Ala Leu Cys Phe Leu Pro Cys Phe Leu 
225                 230                 235                 240 


Ala Arg Val Leu Met His Ile Phe Gln Asn Leu Gly Ser Cys Arg Ala 
                245                 250                 255     


Leu Cys Ala Val Ala His Thr Ser Asp Val Thr Gly Ser Leu Thr Tyr 
            260                 265                 270         


Leu His Ser Val Leu Asn Pro Val Val Tyr Cys Phe Ser Ser Pro Thr 
        275                 280                 285             


Phe Arg Ser Ser Tyr Arg Arg Val Phe His Thr Leu Arg Gly Lys Gly 
    290                 295                 300                 


Gln Ala Ala Glu Pro Pro Asp Phe Asn Pro Arg Asp Ser Tyr Ser 
305                 310                 315                 


<210>  3266
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  3266

Met Arg Ser His Thr Ile Thr Met Thr Thr Thr Ser Val Ser Ser Trp 
1               5                   10                  15      


Pro Tyr Ser Ser His Arg Met Arg Phe Ile Thr Asn His Ser Asp Gln 
            20                  25                  30          


Pro Pro Gln Asn Phe Ser Ala Thr Pro Asn Val Thr Thr Cys Pro Met 
        35                  40                  45              


Asp Glu Lys Leu Leu Ser Thr Val Leu Thr Thr Ser Tyr Ser Val Ile 
    50                  55                  60                  


Phe Ile Val Gly Leu Val Gly Asn Ile Ile Ala Leu Tyr Val Phe Leu 
65                  70                  75                  80  


Gly Ile His Arg Lys Arg Asn Ser Ile Gln Ile Tyr Leu Leu Asn Val 
                85                  90                  95      


Ala Ile Ala Asp Leu Leu Leu Ile Phe Cys Leu Pro Phe Arg Ile Met 
            100                 105                 110         


Tyr His Ile Asn Gln Asn Lys Trp Thr Leu Gly Val Ile Leu Cys Lys 
        115                 120                 125             


Val Val Gly Thr Leu Phe Tyr Met Asn Met Tyr Ile Ser Ile Ile Leu 
    130                 135                 140                 


Leu Gly Phe Ile Ser Leu Asp Arg Tyr Ile Lys Ile Asn Arg Ser Ile 
145                 150                 155                 160 


Gln Gln Arg Lys Ala Ile Thr Thr Lys Gln Ser Ile Tyr Val Cys Cys 
                165                 170                 175     


Ile Val Trp Met Leu Ala Leu Gly Gly Phe Leu Thr Met Ile Ile Leu 
            180                 185                 190         


Thr Leu Lys Lys Gly Gly His Asn Ser Thr Met Cys Phe His Tyr Arg 
        195                 200                 205             


Asp Lys His Asn Ala Lys Gly Glu Ala Ile Phe Asn Phe Ile Leu Val 
    210                 215                 220                 


Val Met Phe Trp Leu Ile Phe Leu Leu Ile Ile Leu Ser Tyr Ile Lys 
225                 230                 235                 240 


Ile Gly Lys Asn Leu Leu Arg Ile Ser Lys Arg Arg Ser Lys Phe Pro 
                245                 250                 255     


Asn Ser Gly Lys Tyr Ala Thr Thr Ala Arg Asn Ser Phe Ile Val Leu 
            260                 265                 270         


Ile Ile Phe Thr Ile Cys Phe Val Pro Tyr His Ala Phe Arg Phe Ile 
        275                 280                 285             


Tyr Ile Ser Ser Gln Leu Asn Val Ser Ser Cys Tyr Trp Lys Glu Ile 
    290                 295                 300                 


Val His Lys Thr Asn Glu Ile Met Leu Val Leu Ser Ser Phe Asn Ser 
305                 310                 315                 320 


Cys Leu Asp Pro Val Met Tyr Phe Leu Met Ser Ser Asn Ile Arg Lys 
                325                 330                 335     


Ile Met Cys Gln Leu Leu Phe Arg Arg Phe Gln Gly Glu Pro Ser Arg 
            340                 345                 350         


Ser Glu Ser Thr Ser Glu Phe Lys Pro Gly Tyr Ser Leu His Asp Thr 
        355                 360                 365             


Ser Val Ala Val Lys Ile Gln Ser Ser Ser Lys Ser Thr 
    370                 375                 380     


<210>  3267
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  3267

Met Asn Gly Thr Tyr Asn Thr Cys Gly Ser Ser Asp Leu Thr Trp Pro 
1               5                   10                  15      


Pro Ala Ile Lys Leu Gly Phe Tyr Ala Tyr Leu Gly Val Leu Leu Val 
            20                  25                  30          


Leu Gly Leu Leu Leu Asn Ser Leu Ala Leu Trp Val Phe Cys Cys Arg 
        35                  40                  45              


Met Gln Gln Trp Thr Glu Thr Arg Ile Tyr Met Thr Asn Leu Ala Val 
    50                  55                  60                  


Ala Asp Leu Cys Leu Leu Cys Thr Leu Pro Phe Val Leu His Ser Leu 
65                  70                  75                  80  


Arg Asp Thr Ser Asp Thr Pro Leu Cys Gln Leu Ser Gln Gly Ile Tyr 
                85                  90                  95      


Leu Thr Asn Arg Tyr Met Ser Ile Ser Leu Val Thr Ala Ile Ala Val 
            100                 105                 110         


Asp Arg Tyr Val Ala Val Arg His Pro Leu Arg Ala Arg Gly Leu Arg 
        115                 120                 125             


Ser Pro Arg Gln Ala Ala Ala Val Cys Ala Val Leu Trp Val Leu Val 
    130                 135                 140                 


Ile Gly Ser Leu Val Ala Arg Trp Leu Leu Gly Ile Gln Glu Gly Gly 
145                 150                 155                 160 


Phe Cys Phe Arg Ser Thr Arg His Asn Phe Asn Ser Met Ala Phe Pro 
                165                 170                 175     


Leu Leu Gly Phe Tyr Leu Pro Leu Ala Val Val Val Phe Cys Ser Leu 
            180                 185                 190         


Lys Val Val Thr Ala Leu Ala Gln Arg Pro Pro Thr Asp Val Gly Gln 
        195                 200                 205             


Ala Glu Ala Thr Arg Lys Ala Ala Arg Met Val Trp Ala Asn Leu Leu 
    210                 215                 220                 


Val Phe Val Val Cys Phe Leu Pro Leu His Val Gly Leu Thr Val Arg 
225                 230                 235                 240 


Leu Ala Val Gly Trp Asn Ala Cys Ala Leu Leu Glu Thr Ile Arg Arg 
                245                 250                 255     


Ala Leu Tyr Ile Thr Ser Lys Leu Ser Asp Ala Asn Cys Cys Leu Asp 
            260                 265                 270         


Ala Ile Cys Tyr Tyr Tyr Met Ala Lys Glu Phe Gln Glu Ala Ser Ala 
        275                 280                 285             


Leu Ala Val Ala Pro Ser Ala Lys Ala His Lys Ser Gln Asp Ser Leu 
    290                 295                 300                 


Cys Val Thr Leu Ala 
305                 


<210>  3268
<211>  613
<212>  PRT
<213>  Homo sapiens

<400>  3268

Met Arg Ala Pro Gly Ala Leu Leu Ala Arg Met Ser Arg Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Lys Val Ser Ala Ser Ser Ala Leu Gly Val Ala Pro 
            20                  25                  30          


Ala Ser Arg Asn Glu Thr Cys Leu Gly Glu Ser Cys Ala Pro Thr Val 
        35                  40                  45              


Ile Gln Arg Arg Gly Arg Asp Ala Trp Gly Pro Gly Asn Ser Ala Arg 
    50                  55                  60                  


Asp Val Leu Arg Ala Arg Ala Pro Arg Glu Glu Gln Gly Ala Ala Phe 
65                  70                  75                  80  


Leu Ala Gly Pro Ser Trp Asp Leu Pro Ala Ala Pro Gly Arg Asp Pro 
                85                  90                  95      


Ala Ala Gly Arg Gly Ala Glu Ala Ser Ala Ala Gly Pro Pro Gly Pro 
            100                 105                 110         


Pro Thr Arg Pro Pro Gly Pro Trp Arg Trp Lys Gly Ala Arg Gly Gln 
        115                 120                 125             


Glu Pro Ser Glu Thr Leu Gly Arg Gly Asn Pro Thr Ala Leu Gln Leu 
    130                 135                 140                 


Phe Leu Gln Ile Ser Glu Glu Glu Glu Lys Gly Pro Arg Gly Ala Gly 
145                 150                 155                 160 


Ile Ser Gly Arg Ser Gln Glu Gln Ser Val Lys Thr Val Pro Gly Ala 
                165                 170                 175     


Ser Asp Leu Phe Tyr Trp Pro Arg Arg Ala Gly Lys Leu Gln Gly Ser 
            180                 185                 190         


His His Lys Pro Leu Ser Lys Thr Ala Asn Gly Leu Ala Gly His Glu 
        195                 200                 205             


Gly Trp Thr Ile Ala Leu Pro Gly Arg Ala Leu Ala Gln Asn Gly Ser 
    210                 215                 220                 


Leu Gly Glu Gly Ile His Glu Pro Gly Gly Pro Arg Arg Gly Asn Ser 
225                 230                 235                 240 


Thr Asn Arg Arg Val Arg Leu Lys Asn Pro Phe Tyr Pro Leu Thr Gln 
                245                 250                 255     


Glu Ser Tyr Gly Ala Tyr Ala Val Met Cys Leu Ser Val Val Ile Phe 
            260                 265                 270         


Gly Thr Gly Ile Ile Gly Asn Leu Ala Val Met Cys Ile Val Cys His 
        275                 280                 285             


Asn Tyr Tyr Met Arg Ser Ile Ser Asn Ser Leu Leu Ala Asn Leu Ala 
    290                 295                 300                 


Phe Trp Asp Phe Leu Ile Ile Phe Phe Cys Leu Pro Leu Val Ile Phe 
305                 310                 315                 320 


His Glu Leu Thr Lys Lys Trp Leu Leu Glu Asp Phe Ser Cys Lys Ile 
                325                 330                 335     


Val Pro Tyr Ile Glu Val Ala Ser Leu Gly Val Thr Thr Phe Thr Leu 
            340                 345                 350         


Cys Ala Leu Cys Ile Asp Arg Phe Arg Ala Ala Thr Asn Val Gln Met 
        355                 360                 365             


Tyr Tyr Glu Met Ile Glu Asn Cys Ser Ser Thr Thr Ala Lys Leu Ala 
    370                 375                 380                 


Val Ile Trp Val Gly Ala Leu Leu Leu Ala Leu Pro Glu Val Val Leu 
385                 390                 395                 400 


Arg Gln Leu Ser Lys Glu Asp Leu Gly Phe Ser Gly Arg Ala Pro Ala 
                405                 410                 415     


Glu Arg Cys Ile Ile Lys Ile Ser Pro Asp Leu Pro Asp Thr Ile Tyr 
            420                 425                 430         


Val Leu Ala Leu Thr Tyr Asp Ser Ala Arg Leu Trp Trp Tyr Phe Gly 
        435                 440                 445             


Cys Tyr Phe Cys Leu Pro Thr Leu Phe Thr Ile Thr Cys Ser Leu Val 
    450                 455                 460                 


Thr Ala Arg Lys Ile Arg Lys Ala Glu Lys Ala Cys Thr Arg Gly Asn 
465                 470                 475                 480 


Lys Arg Gln Ile Gln Leu Glu Ser Gln Met Asn Cys Thr Val Val Ala 
                485                 490                 495     


Leu Thr Ile Leu Tyr Gly Phe Cys Ile Ile Pro Glu Asn Ile Cys Asn 
            500                 505                 510         


Ile Val Thr Ala Tyr Met Ala Thr Gly Val Ser Gln Gln Thr Met Asp 
        515                 520                 525             


Leu Leu Asn Ile Ile Ser Gln Phe Leu Leu Phe Phe Lys Ser Cys Val 
    530                 535                 540                 


Thr Pro Val Leu Leu Phe Cys Leu Cys Lys Pro Phe Ser Arg Ala Phe 
545                 550                 555                 560 


Met Glu Cys Cys Cys Cys Cys Cys Glu Glu Cys Ile Gln Lys Ser Ser 
                565                 570                 575     


Thr Val Thr Ser Asp Asp Asn Asp Asn Glu Tyr Thr Thr Glu Leu Glu 
            580                 585                 590         


Leu Ser Pro Phe Ser Thr Ile Arg Arg Glu Met Ser Thr Phe Ala Ser 
        595                 600                 605             


Val Gly Thr His Cys 
    610             


<210>  3269
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  3269

Met Asp Leu Pro Pro Gln Leu Ser Phe Gly Leu Tyr Val Ala Ala Phe 
1               5                   10                  15      


Ala Leu Gly Phe Pro Leu Asn Val Leu Ala Ile Arg Gly Ala Thr Ala 
            20                  25                  30          


His Ala Arg Leu Arg Leu Thr Pro Ser Leu Val Tyr Ala Leu Asn Leu 
        35                  40                  45              


Gly Cys Ser Asp Leu Leu Leu Thr Val Ser Leu Pro Leu Lys Ala Val 
    50                  55                  60                  


Glu Ala Leu Ala Ser Gly Ala Trp Pro Leu Pro Ala Ser Leu Cys Pro 
65                  70                  75                  80  


Val Phe Ala Val Ala His Phe Phe Pro Leu Tyr Ala Gly Gly Gly Phe 
                85                  90                  95      


Leu Ala Ala Leu Ser Ala Gly Arg Tyr Leu Gly Ala Ala Phe Pro Leu 
            100                 105                 110         


Gly Tyr Gln Ala Phe Arg Arg Pro Cys Tyr Ser Trp Gly Val Cys Ala 
        115                 120                 125             


Ala Ile Trp Ala Leu Val Leu Cys His Leu Gly Leu Val Phe Gly Leu 
    130                 135                 140                 


Glu Ala Pro Gly Gly Trp Leu Asp His Ser Asn Thr Ser Leu Gly Ile 
145                 150                 155                 160 


Asn Thr Pro Val Asn Gly Ser Pro Val Cys Leu Glu Ala Trp Asp Pro 
                165                 170                 175     


Ala Ser Ala Gly Pro Ala Arg Phe Ser Leu Ser Leu Leu Leu Phe Phe 
            180                 185                 190         


Leu Pro Leu Ala Ile Thr Ala Phe Cys Tyr Val Gly Cys Leu Arg Ala 
        195                 200                 205             


Leu Ala Arg Ser Gly Leu Thr His Arg Arg Lys Leu Arg Ala Ala Trp 
    210                 215                 220                 


Val Ala Gly Gly Ala Leu Leu Thr Leu Leu Leu Cys Val Gly Pro Tyr 
225                 230                 235                 240 


Asn Ala Ser Asn Val Ala Ser Phe Leu Tyr Pro Asn Leu Gly Gly Ser 
                245                 250                 255     


Trp Arg Lys Leu Gly Leu Ile Thr Gly Ala Trp Ser Val Val Leu Asn 
            260                 265                 270         


Pro Leu Val Thr Gly Tyr Leu Gly Arg Gly Pro Gly Leu Lys Thr Val 
        275                 280                 285             


Cys Ala Ala Arg Thr Gln Gly Gly Lys Ser Gln Lys 
    290                 295                 300 


<210>  3270
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  3270

Met Leu Pro Asp Trp Lys Ser Ser Leu Ile Leu Met Ala Tyr Ile Ile 
1               5                   10                  15      


Ile Phe Leu Thr Gly Leu Pro Ala Asn Leu Leu Ala Leu Arg Ala Phe 
            20                  25                  30          


Val Gly Arg Ile Arg Gln Pro Gln Pro Ala Pro Val His Ile Leu Leu 
        35                  40                  45              


Leu Ser Leu Thr Leu Ala Asp Leu Leu Leu Leu Leu Leu Leu Pro Phe 
    50                  55                  60                  


Lys Ile Ile Glu Ala Ala Ser Asn Phe Arg Trp Tyr Leu Pro Lys Val 
65                  70                  75                  80  


Val Cys Ala Leu Thr Ser Phe Gly Phe Tyr Ser Ser Ile Tyr Cys Ser 
                85                  90                  95      


Thr Trp Leu Leu Ala Gly Ile Ser Ile Glu Arg Tyr Leu Gly Val Ala 
            100                 105                 110         


Phe Pro Val Gln Tyr Lys Leu Ser Arg Arg Pro Leu Tyr Gly Val Ile 
        115                 120                 125             


Ala Ala Leu Val Ala Trp Val Met Ser Phe Gly His Cys Thr Ile Val 
    130                 135                 140                 


Ile Ile Val Gln Tyr Leu Asn Thr Thr Glu Gln Val Arg Ser Gly Asn 
145                 150                 155                 160 


Glu Ile Thr Cys Tyr Glu Asn Phe Thr Asp Asn Gln Leu Asp Val Val 
                165                 170                 175     


Leu Pro Val Arg Leu Glu Leu Cys Leu Val Leu Phe Phe Ile Pro Met 
            180                 185                 190         


Ala Val Thr Ile Phe Cys Tyr Trp Arg Phe Val Trp Ile Met Leu Ser 
        195                 200                 205             


Gln Pro Leu Val Gly Ala Gln Arg Arg Arg Arg Ala Val Gly Leu Ala 
    210                 215                 220                 


Val Val Thr Leu Leu Asn Phe Leu Val Cys Phe Gly Pro Tyr Asn Val 
225                 230                 235                 240 


Ser His Leu Val Gly Tyr His Gln Arg Lys Ser Pro Trp Trp Arg Ser 
                245                 250                 255     


Ile Ala Val Val Phe Ser Ser Leu Asn Ala Ser Leu Asp Pro Leu Leu 
            260                 265                 270         


Phe Tyr Phe Ser Ser Ser Val Val Arg Arg Ala Phe Gly Arg Gly Leu 
        275                 280                 285             


Gln Val Leu Arg Asn Gln Gly Ser Ser Leu Leu Gly Arg Arg Gly Lys 
    290                 295                 300                 


Asp Thr Ala Glu Gly Thr Asn Glu Asp Arg Gly Val Gly Gln Gly Glu 
305                 310                 315                 320 


Gly Met Pro Ser Ser Asp Phe Thr Thr Glu 
                325                 330 


<210>  3271
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  3271

Met Ala Leu Asn Asp Cys Phe Leu Leu Asn Leu Glu Val Asp His Phe 
1               5                   10                  15      


Met His Cys Asn Ile Ser Ser His Ser Ala Asp Leu Pro Val Asn Asp 
            20                  25                  30          


Asp Trp Ser His Pro Gly Ile Leu Tyr Val Ile Pro Ala Val Tyr Gly 
        35                  40                  45              


Val Ile Ile Leu Ile Gly Leu Ile Gly Asn Ile Thr Leu Ile Lys Ile 
    50                  55                  60                  


Phe Cys Thr Val Lys Ser Met Arg Asn Val Pro Asn Leu Phe Ile Ser 
65                  70                  75                  80  


Ser Leu Ala Leu Gly Asp Leu Leu Leu Leu Ile Thr Cys Ala Pro Val 
                85                  90                  95      


Asp Ala Ser Arg Tyr Leu Ala Asp Arg Trp Leu Phe Gly Arg Ile Gly 
            100                 105                 110         


Cys Lys Leu Ile Pro Phe Ile Gln Leu Thr Ser Val Gly Val Ser Val 
        115                 120                 125             


Phe Thr Leu Thr Ala Leu Ser Ala Asp Arg Tyr Lys Ala Ile Val Arg 
    130                 135                 140                 


Pro Met Asp Ile Gln Ala Ser His Ala Leu Met Lys Ile Cys Leu Lys 
145                 150                 155                 160 


Ala Ala Phe Ile Trp Ile Ile Ser Met Leu Leu Ala Ile Pro Glu Ala 
                165                 170                 175     


Val Phe Ser Asp Leu His Pro Phe His Glu Glu Ser Thr Asn Gln Thr 
            180                 185                 190         


Phe Ile Ser Cys Ala Pro Tyr Pro His Ser Asn Glu Leu His Pro Lys 
        195                 200                 205             


Ile His Ser Met Ala Ser Phe Leu Val Phe Tyr Val Ile Pro Leu Ser 
    210                 215                 220                 


Ile Ile Ser Val Tyr Tyr Tyr Phe Ile Ala Lys Asn Leu Ile Gln Ser 
225                 230                 235                 240 


Ala Tyr Asn Leu Pro Val Glu Gly Asn Ile His Val Lys Lys Gln Ile 
                245                 250                 255     


Glu Ser Arg Lys Arg Leu Ala Lys Thr Val Leu Val Phe Val Gly Leu 
            260                 265                 270         


Phe Ala Phe Cys Trp Leu Pro Asn His Val Ile Tyr Leu Tyr Arg Ser 
        275                 280                 285             


Tyr His Tyr Ser Glu Val Asp Thr Ser Met Leu His Phe Val Thr Ser 
    290                 295                 300                 


Ile Cys Ala Arg Leu Leu Ala Phe Thr Asn Ser Cys Val Asn Pro Phe 
305                 310                 315                 320 


Ala Leu Tyr Leu Leu Ser Lys Ser Phe Arg Lys Gln Phe Asn Thr Gln 
                325                 330                 335     


Leu Leu Cys Cys Gln Pro Gly Leu Ile Ile Arg Ser His Ser Thr Gly 
            340                 345                 350         


Arg Ser Thr Thr Cys Met Thr Ser Leu Lys Ser Thr Asn Pro Ser Val 
        355                 360                 365             


Ala Thr Phe Ser Leu Ile Asn Gly Asn Ile Cys His Glu Arg Tyr Val 
    370                 375                 380                 


<210>  3272
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  3272

Met Ala Phe Val Thr Arg Gln Phe Met Arg Ser Val Ser Ser Ser Ser 
1               5                   10                  15      


Thr Ala Ser Ala Ser Ala Lys Lys Ile Ile Val Lys His Val Thr Val 
            20                  25                  30          


Ile Gly Gly Gly Leu Met Gly Ala Gly Ile Ala Gln Val Ala Ala Ala 
        35                  40                  45              


Thr Gly His Thr Val Val Leu Val Asp Gln Thr Glu Asp Ile Leu Ala 
    50                  55                  60                  


Lys Ser Lys Lys Gly Ile Glu Glu Ser Leu Arg Lys Val Ala Lys Lys 
65                  70                  75                  80  


Lys Phe Ala Glu Asn Pro Lys Ala Gly Asp Glu Phe Val Glu Lys Thr 
                85                  90                  95      


Leu Ser Thr Ile Ala Thr Ser Thr Asp Ala Ala Ser Val Val His Ser 
            100                 105                 110         


Thr Asp Leu Val Val Glu Ala Ile Val Glu Asn Leu Lys Val Lys Asn 
        115                 120                 125             


Glu Leu Phe Lys Arg Leu Asp Lys Phe Ala Ala Glu His Thr Ile Phe 
    130                 135                 140                 


Ala Ser Asn Thr Ser Ser Leu Gln Ile Thr Ser Ile Ala Asn Ala Thr 
145                 150                 155                 160 


Thr Arg Gln Asp Arg Phe Ala Gly Leu His Phe Phe Asn Pro Val Pro 
                165                 170                 175     


Val Met Lys Leu Val Glu Val Ile Lys Thr Pro Met Thr Ser Gln Lys 
            180                 185                 190         


Thr Phe Glu Ser Leu Val Asp Phe Ser Lys Ala Leu Gly Lys His Pro 
        195                 200                 205             


Val Ser Cys Lys Asp Thr Pro Gly Phe Ile Val Asn Arg Leu Leu Val 
    210                 215                 220                 


Pro Tyr Leu Met Glu Ala Ile Arg Leu Tyr Glu Arg Gly Asp Ala Ser 
225                 230                 235                 240 


Lys Glu Asp Ile Asp Thr Ala Met Lys Leu Gly Ala Gly Tyr Pro Met 
                245                 250                 255     


Gly Pro Phe Glu Leu Leu Asp Tyr Val Gly Leu Asp Thr Thr Lys Phe 
            260                 265                 270         


Ile Val Asp Gly Trp His Glu Met Asp Ala Glu Asn Pro Leu His Gln 
        275                 280                 285             


Pro Ser Pro Ser Leu Asn Lys Leu Val Ala Glu Asn Lys Phe Gly Lys 
    290                 295                 300                 


Lys Thr Gly Glu Gly Phe Tyr Lys Tyr Lys 
305                 310                 


<210>  3273
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  3273

Met His Cys Glu Arg Phe Leu Cys Ile Leu Arg Ile Ile Gly Thr Thr 
1               5                   10                  15      


Leu Phe Gly Val Ser Leu Leu Leu Gly Ile Thr Ala Ala Tyr Ile Val 
            20                  25                  30          


Gly Tyr Gln Phe Ile Gln Thr Asp Asn Tyr Tyr Phe Ser Phe Gly Leu 
        35                  40                  45              


Tyr Gly Ala Phe Leu Ala Ser His Leu Ile Ile Gln Ser Leu Phe Ala 
    50                  55                  60                  


Phe Leu Glu His Arg Lys Met Lys Lys Ser Leu Glu Thr Pro Ile Lys 
65                  70                  75                  80  


Leu Asn Lys Thr Val Ala Leu Cys Ile Ala Ala Tyr Gln Glu Asp Pro 
                85                  90                  95      


Asp Tyr Leu Arg Lys Cys Leu Gln Ser Val Lys Arg Leu Thr Tyr Pro 
            100                 105                 110         


Gly Ile Lys Val Val Met Val Ile Asp Gly Asn Ser Glu Asp Asp Leu 
        115                 120                 125             


Tyr Met Met Asp Ile Phe Ser Glu Val Met Gly Arg Asp Lys Ser Ala 
    130                 135                 140                 


Thr Tyr Ile Trp Lys Asn Asn Phe His Glu Lys Gly Pro Gly Glu Thr 
145                 150                 155                 160 


Asp Glu Ser His Lys Glu Ser Ser Gln His Val Thr Gln Leu Val Leu 
                165                 170                 175     


Ser Asn Lys Ser Ile Cys Ile Met Gln Lys Trp Gly Gly Lys Arg Glu 
            180                 185                 190         


Val Met Tyr Thr Ala Phe Arg Ala Leu Gly Arg Ser Val Asp Tyr Val 
        195                 200                 205             


Gln Val Cys Asp Ser Asp Thr Met Leu Asp Pro Ala Ser Ser Val Glu 
    210                 215                 220                 


Met Val Lys Val Leu Glu Glu Asp Pro Met Val Gly Gly Val Gly Gly 
225                 230                 235                 240 


Asp Val Gln Ile Leu Asn Lys Tyr Asp Ser Trp Ile Ser Phe Leu Ser 
                245                 250                 255     


Ser Val Arg Tyr Trp Met Ala Phe Asn Ile Glu Arg Ala Cys Gln Ser 
            260                 265                 270         


Tyr Phe Gly Cys Val Gln Cys Ile Ser Gly Pro Leu Gly Met Tyr Arg 
        275                 280                 285             


Asn Ser Leu Leu His Glu Phe Val Glu Asp Trp Tyr Asn Gln Glu Phe 
    290                 295                 300                 


Met Gly Asn Gln Cys Ser Phe Gly Asp Asp Arg His Leu Thr Asn Arg 
305                 310                 315                 320 


Val Leu Ser Leu Gly Tyr Ala Thr Lys Tyr Thr Ala Arg Ser Lys Cys 
                325                 330                 335     


Leu Thr Glu Thr Pro Ile Glu Tyr Leu Arg Trp Leu Asn Gln Gln Thr 
            340                 345                 350         


Arg Trp Ser Lys Ser Tyr Phe Arg Glu Trp Leu Tyr Asn Ala Met Trp 
        355                 360                 365             


Phe His Lys His His Leu Trp Met Thr Tyr Glu Ala Ile Ile Thr Gly 
    370                 375                 380                 


Phe Phe Pro Phe Phe Leu Ile Ala Thr Val Ile Gln Leu Phe Tyr Arg 
385                 390                 395                 400 


Gly Lys Ile Trp Asn Ile Leu Leu Phe Leu Leu Thr Val Gln Leu Val 
                405                 410                 415     


Gly Leu Ile Lys Ser Ser Phe Ala Ser Cys Leu Arg Gly Asn Ile Val 
            420                 425                 430         


Met Val Phe Met Ser Leu Tyr Ser Val Leu Tyr Met Ser Ser Leu Leu 
        435                 440                 445             


Pro Ala Lys Met Phe Ala Ile Ala Thr Ile Asn Lys Ala Gly Trp Gly 
    450                 455                 460                 


Thr Ser Gly Arg Lys Thr Ile Val Val Asn Phe Ile Gly Leu Ile Pro 
465                 470                 475                 480 


Val Ser Val Trp Phe Thr Ile Leu Leu Gly Gly Val Ile Phe Thr Ile 
                485                 490                 495     


Tyr Lys Glu Ser Lys Arg Pro Phe Ser Glu Ser Lys Gln Thr Val Leu 
            500                 505                 510         


Ile Val Gly Thr Leu Leu Tyr Ala Cys Tyr Trp Val Met Leu Leu Thr 
        515                 520                 525             


Leu Tyr Val Val Leu Ile Asn Lys Cys Gly Arg Arg Lys Lys Gly Gln 
    530                 535                 540                 


Gln Tyr Asp Met Val Leu Asp Val 
545                 550         


<210>  3274
<211>  553
<212>  PRT
<213>  Homo sapiens

<400>  3274

Met Pro Val Gln Leu Thr Thr Ala Leu Arg Val Val Gly Thr Ser Leu 
1               5                   10                  15      


Phe Ala Leu Ala Val Leu Gly Gly Ile Leu Ala Ala Tyr Val Thr Gly 
            20                  25                  30          


Tyr Gln Phe Ile His Thr Glu Lys His Tyr Leu Ser Phe Gly Leu Tyr 
        35                  40                  45              


Gly Ala Ile Leu Gly Leu His Leu Leu Ile Gln Ser Leu Phe Ala Phe 
    50                  55                  60                  


Leu Glu His Arg Arg Met Arg Arg Ala Gly Gln Ala Leu Lys Leu Pro 
65                  70                  75                  80  


Ser Pro Arg Arg Gly Ser Val Ala Leu Cys Ile Ala Ala Tyr Gln Glu 
                85                  90                  95      


Asp Pro Asp Tyr Leu Arg Lys Cys Leu Arg Ser Ala Gln Arg Ile Ser 
            100                 105                 110         


Phe Pro Asp Leu Lys Val Val Met Val Val Asp Gly Asn Arg Gln Glu 
        115                 120                 125             


Asp Ala Tyr Met Leu Asp Ile Phe His Glu Val Leu Gly Gly Thr Glu 
    130                 135                 140                 


Gln Ala Gly Phe Phe Val Trp Arg Ser Asn Phe His Glu Ala Gly Glu 
145                 150                 155                 160 


Gly Glu Thr Glu Ala Ser Leu Gln Glu Gly Met Asp Arg Val Arg Asp 
                165                 170                 175     


Val Val Arg Ala Ser Thr Phe Ser Cys Ile Met Gln Lys Trp Gly Gly 
            180                 185                 190         


Lys Arg Glu Val Met Tyr Thr Ala Phe Lys Ala Leu Gly Asp Ser Val 
        195                 200                 205             


Asp Tyr Ile Gln Val Cys Asp Ser Asp Thr Val Leu Asp Pro Ala Cys 
    210                 215                 220                 


Thr Ile Glu Met Leu Arg Val Leu Glu Glu Asp Pro Gln Val Gly Gly 
225                 230                 235                 240 


Val Gly Gly Asp Val Gln Ile Leu Asn Lys Tyr Asp Ser Trp Ile Ser 
                245                 250                 255     


Phe Leu Ser Ser Val Arg Tyr Trp Met Ala Phe Asn Val Glu Arg Ala 
            260                 265                 270         


Cys Gln Ser Tyr Phe Gly Cys Val Gln Cys Ile Ser Gly Pro Leu Gly 
        275                 280                 285             


Met Tyr Arg Asn Ser Leu Leu Gln Gln Phe Leu Glu Asp Trp Tyr His 
    290                 295                 300                 


Gln Lys Phe Leu Gly Ser Lys Cys Ser Phe Gly Asp Asp Arg His Leu 
305                 310                 315                 320 


Thr Asn Arg Val Leu Ser Leu Gly Tyr Arg Thr Lys Tyr Thr Ala Arg 
                325                 330                 335     


Ser Lys Cys Leu Thr Glu Thr Pro Thr Lys Tyr Leu Arg Trp Leu Asn 
            340                 345                 350         


Gln Gln Thr Arg Trp Ser Lys Ser Tyr Phe Arg Glu Trp Leu Tyr Asn 
        355                 360                 365             


Ser Leu Trp Phe His Lys His His Leu Trp Met Thr Tyr Glu Ser Val 
    370                 375                 380                 


Val Thr Gly Phe Phe Pro Phe Phe Leu Ile Ala Thr Val Ile Gln Leu 
385                 390                 395                 400 


Phe Tyr Arg Gly Arg Ile Trp Asn Ile Leu Leu Phe Leu Leu Thr Val 
                405                 410                 415     


Gln Leu Val Gly Ile Ile Lys Ala Thr Tyr Ala Cys Phe Leu Arg Gly 
            420                 425                 430         


Asn Ala Glu Met Ile Phe Met Ser Leu Tyr Ser Leu Leu Tyr Met Ser 
        435                 440                 445             


Ser Leu Leu Pro Ala Lys Ile Phe Ala Ile Ala Thr Ile Asn Lys Ser 
    450                 455                 460                 


Gly Trp Gly Thr Ser Gly Arg Lys Thr Ile Val Val Asn Phe Ile Gly 
465                 470                 475                 480 


Leu Ile Pro Val Ser Ile Trp Val Ala Val Leu Leu Gly Gly Leu Ala 
                485                 490                 495     


Tyr Thr Ala Tyr Cys Gln Asp Leu Phe Ser Glu Thr Glu Leu Ala Phe 
            500                 505                 510         


Leu Val Ser Gly Ala Ile Leu Tyr Gly Cys Tyr Trp Val Ala Leu Leu 
        515                 520                 525             


Met Leu Tyr Leu Ala Ile Ile Ala Arg Arg Cys Gly Lys Lys Pro Glu 
    530                 535                 540                 


Gln Tyr Ser Leu Ala Phe Ala Glu Val 
545                 550             


<210>  3275
<211>  1161
<212>  PRT
<213>  Homo sapiens

<400>  3275

Met Thr Phe Gly Thr Val Leu Leu Leu Ser Val Leu Ala Ser Tyr His 
1               5                   10                  15      


Gly Phe Asn Leu Asp Val Glu Glu Pro Thr Ile Phe Gln Glu Asp Ala 
            20                  25                  30          


Gly Gly Phe Gly Gln Ser Val Val Gln Phe Gly Gly Ser Arg Leu Val 
        35                  40                  45              


Val Gly Ala Pro Leu Glu Val Val Ala Ala Asn Gln Thr Gly Arg Leu 
    50                  55                  60                  


Tyr Asp Cys Ala Ala Ala Thr Gly Met Cys Gln Pro Ile Pro Leu His 
65                  70                  75                  80  


Ile Arg Pro Glu Ala Val Asn Met Ser Leu Gly Leu Thr Leu Ala Ala 
                85                  90                  95      


Ser Thr Asn Gly Ser Arg Leu Leu Ala Cys Gly Pro Thr Leu His Arg 
            100                 105                 110         


Val Cys Gly Glu Asn Ser Tyr Ser Lys Gly Ser Cys Leu Leu Leu Gly 
        115                 120                 125             


Ser Arg Trp Glu Ile Ile Gln Thr Val Pro Asp Ala Thr Pro Glu Cys 
    130                 135                 140                 


Pro His Gln Glu Met Asp Ile Val Phe Leu Ile Asp Gly Ser Gly Ser 
145                 150                 155                 160 


Ile Asp Gln Asn Asp Phe Asn Gln Met Lys Gly Phe Val Gln Ala Val 
                165                 170                 175     


Met Gly Gln Phe Glu Gly Thr Asp Thr Leu Phe Ala Leu Met Gln Tyr 
            180                 185                 190         


Ser Asn Leu Leu Lys Ile His Phe Thr Phe Thr Gln Phe Arg Thr Ser 
        195                 200                 205             


Pro Ser Gln Gln Ser Leu Val Asp Pro Ile Val Gln Leu Lys Gly Leu 
    210                 215                 220                 


Thr Phe Thr Ala Thr Gly Ile Leu Thr Val Val Thr Gln Leu Phe His 
225                 230                 235                 240 


His Lys Asn Gly Ala Arg Lys Ser Ala Lys Lys Ile Leu Ile Val Ile 
                245                 250                 255     


Thr Asp Gly Gln Lys Tyr Lys Asp Pro Leu Glu Tyr Ser Asp Val Ile 
            260                 265                 270         


Pro Gln Ala Glu Lys Ala Gly Ile Ile Arg Tyr Ala Ile Gly Val Gly 
        275                 280                 285             


His Ala Phe Gln Gly Pro Thr Ala Arg Gln Glu Leu Asn Thr Ile Ser 
    290                 295                 300                 


Ser Ala Pro Pro Gln Asp His Val Phe Lys Val Asp Asn Phe Ala Ala 
305                 310                 315                 320 


Leu Gly Ser Ile Gln Lys Gln Leu Gln Glu Lys Ile Tyr Ala Val Glu 
                325                 330                 335     


Gly Thr Gln Ser Arg Ala Ser Ser Ser Phe Gln His Glu Met Ser Gln 
            340                 345                 350         


Glu Gly Phe Ser Thr Ala Leu Thr Met Asp Gly Leu Phe Leu Gly Ala 
        355                 360                 365             


Val Gly Ser Phe Ser Trp Ser Gly Gly Ala Phe Leu Tyr Pro Pro Asn 
    370                 375                 380                 


Met Ser Pro Thr Phe Ile Asn Met Ser Gln Glu Asn Val Asp Met Arg 
385                 390                 395                 400 


Asp Ser Tyr Leu Gly Tyr Ser Thr Glu Leu Ala Leu Trp Lys Gly Val 
                405                 410                 415     


Gln Asn Leu Val Leu Gly Ala Pro Arg Tyr Gln His Thr Gly Lys Ala 
            420                 425                 430         


Val Ile Phe Thr Gln Val Ser Arg Gln Trp Arg Lys Lys Ala Glu Val 
        435                 440                 445             


Thr Gly Thr Gln Ile Gly Ser Tyr Phe Gly Ala Ser Leu Cys Ser Val 
    450                 455                 460                 


Asp Val Asp Ser Asp Gly Ser Thr Asp Leu Ile Leu Ile Gly Ala Pro 
465                 470                 475                 480 


His Tyr Tyr Glu Gln Thr Arg Gly Gly Gln Val Ser Val Cys Pro Leu 
                485                 490                 495     


Pro Arg Gly Arg Val Gln Trp Gln Cys Asp Ala Val Leu Arg Gly Glu 
            500                 505                 510         


Gln Gly His Pro Trp Gly Arg Phe Gly Ala Ala Leu Thr Val Leu Gly 
        515                 520                 525             


Asp Val Asn Glu Asp Lys Leu Ile Asp Val Ala Ile Gly Ala Pro Gly 
    530                 535                 540                 


Glu Gln Glu Asn Arg Gly Ala Val Tyr Leu Phe His Gly Ala Ser Glu 
545                 550                 555                 560 


Ser Gly Ile Ser Pro Ser His Ser Gln Arg Ile Ala Ser Ser Gln Leu 
                565                 570                 575     


Ser Pro Arg Leu Gln Tyr Phe Gly Gln Ala Leu Ser Gly Gly Gln Asp 
            580                 585                 590         


Leu Thr Gln Asp Gly Leu Met Asp Leu Ala Val Gly Ala Arg Gly Gln 
        595                 600                 605             


Val Leu Leu Leu Arg Ser Leu Pro Val Leu Lys Val Gly Val Ala Met 
    610                 615                 620                 


Arg Phe Ser Pro Val Glu Val Ala Lys Ala Val Tyr Arg Cys Trp Glu 
625                 630                 635                 640 


Glu Lys Pro Ser Ala Leu Glu Ala Gly Asp Ala Thr Val Cys Leu Thr 
                645                 650                 655     


Ile Gln Lys Ser Ser Leu Asp Gln Leu Gly Asp Ile Gln Ser Ser Val 
            660                 665                 670         


Arg Phe Asp Leu Ala Leu Asp Pro Gly Arg Leu Thr Ser Arg Ala Ile 
        675                 680                 685             


Phe Asn Glu Thr Lys Asn Pro Thr Leu Thr Arg Arg Lys Thr Leu Gly 
    690                 695                 700                 


Leu Gly Ile His Cys Glu Thr Leu Lys Leu Leu Leu Pro Asp Cys Val 
705                 710                 715                 720 


Glu Asp Val Val Ser Pro Ile Ile Leu His Leu Asn Phe Ser Leu Val 
                725                 730                 735     


Arg Glu Pro Ile Pro Ser Pro Gln Asn Leu Arg Pro Val Leu Ala Val 
            740                 745                 750         


Gly Ser Gln Asp Leu Phe Thr Ala Ser Leu Pro Phe Glu Lys Asn Cys 
        755                 760                 765             


Gly Gln Asp Gly Leu Cys Glu Gly Asp Leu Gly Val Thr Leu Ser Phe 
    770                 775                 780                 


Ser Gly Leu Gln Thr Leu Thr Val Gly Ser Ser Leu Glu Leu Asn Val 
785                 790                 795                 800 


Ile Val Thr Val Trp Asn Ala Gly Glu Asp Ser Tyr Gly Thr Val Val 
                805                 810                 815     


Ser Leu Tyr Tyr Pro Ala Gly Leu Ser His Arg Arg Val Ser Gly Ala 
            820                 825                 830         


Gln Lys Gln Pro His Gln Ser Ala Leu Arg Leu Ala Cys Glu Thr Val 
        835                 840                 845             


Pro Thr Glu Asp Glu Gly Leu Arg Ser Ser Arg Cys Ser Val Asn His 
    850                 855                 860                 


Pro Ile Phe His Glu Gly Ser Asn Gly Thr Phe Ile Val Thr Phe Asp 
865                 870                 875                 880 


Val Ser Tyr Lys Ala Thr Leu Gly Asp Arg Met Leu Met Arg Ala Ser 
                885                 890                 895     


Ala Ser Ser Glu Asn Asn Lys Ala Ser Ser Ser Lys Ala Thr Phe Gln 
            900                 905                 910         


Leu Glu Leu Pro Val Lys Tyr Ala Val Tyr Thr Met Ile Ser Arg Gln 
        915                 920                 925             


Glu Glu Ser Thr Lys Tyr Phe Asn Phe Ala Thr Ser Asp Glu Lys Lys 
    930                 935                 940                 


Met Lys Glu Ala Glu His Arg Tyr Arg Val Asn Asn Leu Ser Gln Arg 
945                 950                 955                 960 


Asp Leu Ala Ile Ser Ile Asn Phe Trp Val Pro Val Leu Leu Asn Gly 
                965                 970                 975     


Val Ala Val Trp Asp Val Val Met Glu Ala Pro Ser Gln Ser Leu Pro 
            980                 985                 990         


Cys Val Ser Glu Arg Lys Pro Pro  Gln His Ser Asp Phe  Leu Thr Gln 
        995                 1000                 1005             


Ile Ser  Arg Ser Pro Met Leu  Asp Cys Ser Ile Ala  Asp Cys Leu 
    1010                 1015                 1020             


Gln Phe  Arg Cys Asp Val Pro  Ser Phe Ser Val Gln  Glu Glu Leu 
    1025                 1030                 1035             


Asp Phe  Thr Leu Lys Gly Asn  Leu Ser Phe Gly Trp  Val Arg Glu 
    1040                 1045                 1050             


Thr Leu  Gln Lys Lys Val Leu  Val Val Ser Val Ala  Glu Ile Thr 
    1055                 1060                 1065             


Phe Asp  Thr Ser Val Tyr Ser  Gln Leu Pro Gly Gln  Glu Ala Phe 
    1070                 1075                 1080             


Met Arg  Ala Gln Met Glu Met  Val Leu Glu Glu Asp  Glu Val Tyr 
    1085                 1090                 1095             


Asn Ala  Ile Pro Ile Ile Met  Gly Ser Ser Val Gly  Ala Leu Leu 
    1100                 1105                 1110             


Leu Leu  Ala Leu Ile Thr Ala  Thr Leu Tyr Lys Leu  Gly Phe Phe 
    1115                 1120                 1125             


Lys Arg  His Tyr Lys Glu Met  Leu Glu Asp Lys Pro  Glu Asp Thr 
    1130                 1135                 1140             


Ala Thr  Phe Ser Gly Asp Asp  Phe Ser Cys Val Ala  Pro Asn Val 
    1145                 1150                 1155             


Pro Leu  Ser 
    1160     


<210>  3276
<211>  1349
<212>  PRT
<213>  Homo sapiens

<400>  3276

Met Lys Lys Ile Arg Ile Cys His Ile Phe Thr Phe Tyr Ser Trp Met 
1               5                   10                  15      


Ser Tyr Asp Val Leu Phe Gln Arg Thr Glu Leu Gly Ala Leu Glu Ile 
            20                  25                  30          


Trp Arg Gln Leu Ile Cys Ala His Val Cys Ile Cys Val Gly Trp Leu 
        35                  40                  45              


Tyr Leu Arg Asp Arg Val Cys Ser Lys Lys Asp Ile Ile Leu Arg Thr 
    50                  55                  60                  


Glu Gln Asn Ser Gly Arg Thr Ile Leu Ile Lys Ala Val Thr Glu Lys 
65                  70                  75                  80  


Asn Phe Glu Thr Lys Asp Phe Arg Ala Ser Leu Glu Asn Gly Val Leu 
                85                  90                  95      


Leu Cys Asp Leu Ile Asn Lys Leu Lys Pro Gly Val Ile Lys Lys Ile 
            100                 105                 110         


Asn Arg Leu Ser Thr Pro Ile Ala Gly Leu Asp Asn Ile Asn Val Phe 
        115                 120                 125             


Leu Lys Ala Cys Glu Gln Ile Gly Leu Lys Glu Ala Gln Leu Phe His 
    130                 135                 140                 


Pro Gly Asp Leu Gln Asp Leu Ser Asn Arg Val Thr Val Lys Gln Glu 
145                 150                 155                 160 


Glu Thr Asp Arg Arg Val Lys Asn Val Leu Ile Thr Leu Tyr Trp Leu 
                165                 170                 175     


Gly Arg Lys Ala Gln Ser Asn Pro Tyr Tyr Asn Gly Pro His Leu Asn 
            180                 185                 190         


Leu Lys Ala Phe Glu Asn Leu Leu Gly Gln Ala Leu Thr Lys Ala Leu 
        195                 200                 205             


Glu Asp Ser Ser Phe Leu Lys Arg Ser Gly Arg Asp Ser Gly Tyr Gly 
    210                 215                 220                 


Asp Ile Trp Cys Pro Glu Arg Gly Glu Phe Leu Ala Pro Pro Arg His 
225                 230                 235                 240 


His Lys Arg Glu Asp Ser Phe Glu Ser Leu Asp Ser Leu Gly Ser Arg 
                245                 250                 255     


Ser Leu Thr Ser Cys Ser Ser Asp Ile Thr Leu Arg Gly Gly Arg Glu 
            260                 265                 270         


Gly Phe Glu Ser Asp Thr Asp Ser Glu Phe Thr Phe Lys Met Gln Asp 
        275                 280                 285             


Tyr Asn Lys Asp Asp Met Ser Tyr Arg Arg Ile Ser Ala Val Glu Pro 
    290                 295                 300                 


Lys Thr Ala Leu Pro Phe Asn Arg Phe Leu Pro Asn Lys Ser Arg Gln 
305                 310                 315                 320 


Pro Ser Tyr Val Pro Ala Pro Leu Arg Lys Lys Lys Pro Asp Lys His 
                325                 330                 335     


Glu Asp Asn Arg Arg Ser Trp Ala Ser Pro Val Tyr Thr Glu Ala Asp 
            340                 345                 350         


Gly Thr Phe Ser Arg Leu Phe Gln Lys Ile Tyr Gly Glu Asn Gly Ser 
        355                 360                 365             


Lys Ser Met Ser Asp Val Ser Ala Glu Asp Val Gln Asn Leu Arg Gln 
    370                 375                 380                 


Leu Arg Tyr Glu Glu Met Gln Lys Ile Lys Ser Gln Leu Lys Glu Gln 
385                 390                 395                 400 


Asp Gln Lys Trp Gln Asp Asp Leu Ala Lys Trp Lys Asp Arg Arg Lys 
                405                 410                 415     


Ser Tyr Thr Ser Asp Leu Gln Lys Lys Lys Glu Glu Arg Glu Glu Ile 
            420                 425                 430         


Glu Lys Gln Ala Leu Glu Lys Ser Lys Arg Ser Ser Lys Thr Phe Lys 
        435                 440                 445             


Glu Met Leu Gln Asp Arg Glu Ser Gln Asn Gln Lys Ser Thr Val Pro 
    450                 455                 460                 


Ser Arg Arg Arg Met Tyr Ser Phe Asp Asp Val Leu Glu Glu Gly Lys 
465                 470                 475                 480 


Arg Pro Pro Thr Met Thr Val Ser Glu Ala Ser Tyr Gln Ser Glu Arg 
                485                 490                 495     


Val Glu Glu Lys Gly Ala Thr Tyr Pro Ser Glu Ile Pro Lys Glu Asp 
            500                 505                 510         


Ser Thr Thr Phe Ala Lys Arg Glu Asp Arg Val Thr Thr Glu Ile Gln 
        515                 520                 525             


Leu Pro Ser Gln Ser Pro Val Glu Glu Gln Ser Pro Ala Ser Leu Ser 
    530                 535                 540                 


Ser Leu Arg Ser Arg Ser Thr Gln Met Glu Ser Thr Arg Val Ser Ala 
545                 550                 555                 560 


Ser Leu Pro Arg Ser Tyr Arg Lys Thr Asp Thr Val Arg Leu Thr Ser 
                565                 570                 575     


Val Val Thr Pro Arg Pro Phe Gly Ser Gln Thr Arg Gly Ile Ser Ser 
            580                 585                 590         


Leu Pro Arg Ser Tyr Thr Met Asp Asp Ala Trp Lys Tyr Asn Gly Asp 
        595                 600                 605             


Val Glu Asp Ile Lys Arg Thr Pro Asn Asn Val Val Ser Thr Pro Ala 
    610                 615                 620                 


Pro Ser Pro Asp Ala Ser Gln Leu Ala Ser Ser Leu Ser Ser Gln Lys 
625                 630                 635                 640 


Glu Val Ala Ala Thr Glu Glu Asp Val Thr Arg Leu Pro Ser Pro Thr 
                645                 650                 655     


Ser Pro Phe Ser Ser Leu Ser Gln Asp Gln Ala Ala Thr Ser Lys Ala 
            660                 665                 670         


Thr Leu Ser Ser Thr Ser Gly Leu Asp Leu Met Ser Glu Ser Gly Glu 
        675                 680                 685             


Gly Glu Ile Ser Pro Gln Arg Glu Val Ser Arg Ser Gln Asp Gln Phe 
    690                 695                 700                 


Ser Asp Met Arg Ile Ser Ile Asn Gln Thr Pro Gly Lys Ser Leu Asp 
705                 710                 715                 720 


Phe Gly Phe Thr Ile Lys Trp Asp Ile Pro Gly Ile Phe Val Ala Ser 
                725                 730                 735     


Val Glu Ala Gly Ser Pro Ala Glu Phe Ser Gln Leu Gln Val Asp Asp 
            740                 745                 750         


Glu Ile Ile Ala Ile Asn Asn Thr Lys Phe Ser Tyr Asn Asp Ser Lys 
        755                 760                 765             


Glu Trp Glu Glu Ala Met Ala Lys Ala Gln Glu Thr Gly His Leu Val 
    770                 775                 780                 


Met Asp Val Arg Arg Tyr Gly Lys Ala Gly Ser Pro Glu Thr Lys Trp 
785                 790                 795                 800 


Ile Asp Ala Thr Ser Gly Ile Tyr Asn Ser Glu Lys Ser Ser Asn Leu 
                805                 810                 815     


Ser Val Thr Thr Asp Phe Ser Glu Ser Leu Gln Ser Ser Asn Ile Glu 
            820                 825                 830         


Ser Lys Glu Ile Asn Gly Ile His Asp Glu Ser Asn Ala Phe Glu Ser 
        835                 840                 845             


Lys Ala Ser Glu Ser Ile Ser Leu Lys Asn Leu Lys Arg Arg Ser Gln 
    850                 855                 860                 


Phe Phe Glu Gln Gly Ser Ser Asp Ser Val Val Pro Asp Leu Pro Val 
865                 870                 875                 880 


Pro Thr Ile Ser Ala Pro Ser Arg Trp Val Trp Asp Gln Glu Glu Glu 
                885                 890                 895     


Arg Lys Arg Gln Glu Arg Trp Gln Lys Glu Gln Asp Arg Leu Leu Gln 
            900                 905                 910         


Glu Lys Tyr Gln Arg Glu Gln Glu Lys Leu Arg Glu Glu Trp Gln Arg 
        915                 920                 925             


Ala Lys Gln Glu Ala Glu Arg Glu Asn Ser Lys Tyr Leu Asp Glu Glu 
    930                 935                 940                 


Leu Met Val Leu Ser Ser Asn Ser Met Ser Leu Thr Thr Arg Glu Pro 
945                 950                 955                 960 


Ser Leu Ala Thr Trp Glu Ala Thr Trp Ser Glu Gly Ser Lys Ser Ser 
                965                 970                 975     


Asp Arg Glu Gly Thr Arg Ala Gly Glu Glu Glu Arg Arg Gln Pro Gln 
            980                 985                 990         


Glu Glu Val Val His Glu Asp Gln  Gly Lys Lys Pro Gln  Asp Gln Leu 
        995                 1000                 1005             


Val Ile  Glu Arg Glu Arg Lys  Trp Glu Gln Gln Leu  Gln Glu Glu 
    1010                 1015                 1020             


Gln Glu  Gln Lys Arg Leu Gln  Ala Glu Ala Glu Glu  Gln Lys Arg 
    1025                 1030                 1035             


Pro Ala  Glu Glu Gln Lys Arg  Gln Ala Glu Ile Glu  Arg Glu Thr 
    1040                 1045                 1050             


Ser Val  Arg Ile Tyr Gln Tyr  Arg Arg Pro Val Asp  Ser Tyr Asp 
    1055                 1060                 1065             


Ile Pro  Lys Thr Glu Glu Ala  Ser Ser Gly Phe Leu  Pro Gly Asp 
    1070                 1075                 1080             


Arg Asn  Lys Ser Arg Ser Thr  Thr Glu Leu Asp Asp  Tyr Ser Thr 
    1085                 1090                 1095             


Asn Lys  Asn Gly Asn Asn Lys  Tyr Leu Asp Gln Ile  Gly Asn Met 
    1100                 1105                 1110             


Thr Ser  Ser Gln Arg Arg Ser  Lys Lys Glu Gln Val  Pro Ser Gly 
    1115                 1120                 1125             


Ala Glu  Leu Glu Arg Gln Gln  Ile Leu Gln Glu Met  Arg Lys Arg 
    1130                 1135                 1140             


Thr Pro  Leu His Asn Asp Asn  Ser Trp Ile Arg Gln  Arg Ser Ala 
    1145                 1150                 1155             


Ser Val  Asn Lys Glu Pro Val  Ser Leu Pro Gly Ile  Met Arg Arg 
    1160                 1165                 1170             


Gly Glu  Ser Leu Asp Asn Leu  Asp Ser Pro Arg Ser  Asn Ser Trp 
    1175                 1180                 1185             


Arg Gln  Pro Pro Trp Leu Asn  Gln Pro Thr Gly Phe  Tyr Ala Ser 
    1190                 1195                 1200             


Ser Ser  Val Gln Asp Phe Ser  Arg Pro Pro Pro Gln  Leu Val Ser 
    1205                 1210                 1215             


Thr Ser  Asn Arg Ala Tyr Met  Arg Asn Pro Ser Ser  Ser Val Pro 
    1220                 1225                 1230             


Pro Pro  Ser Ala Gly Ser Val  Lys Thr Ser Thr Thr  Gly Val Ala 
    1235                 1240                 1245             


Thr Thr  Gln Ser Pro Thr Pro  Arg Ser His Ser Pro  Ser Ala Ser 
    1250                 1255                 1260             


Gln Ser  Gly Ser Gln Leu Arg  Asn Arg Ser Val Ser  Gly Lys Arg 
    1265                 1270                 1275             


Ile Cys  Ser Tyr Cys Asn Asn  Ile Leu Gly Lys Gly  Ala Ala Met 
    1280                 1285                 1290             


Ile Ile  Glu Ser Leu Gly Leu  Cys Tyr His Leu His  Cys Phe Lys 
    1295                 1300                 1305             


Cys Val  Ala Cys Glu Cys Asp  Leu Gly Gly Ser Ser  Ser Gly Ala 
    1310                 1315                 1320             


Glu Val  Arg Ile Arg Asn His  Gln Leu Tyr Cys Asn  Asp Cys Tyr 
    1325                 1330                 1335             


Leu Arg  Phe Lys Ser Gly Arg  Pro Thr Ala Met 
    1340                 1345                 


<210>  3277
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  3277

Met Pro Ser Pro Leu Ala Leu Arg Pro Tyr Leu Arg Ser Glu Phe Ser 
1               5                   10                  15      


Pro Ser Val Asp Ala Arg Pro Cys Ser Ser Pro Ser Glu Leu Pro Ala 
            20                  25                  30          


Lys Leu Leu Leu Gly Ala Thr Leu Pro Arg Ala Pro Arg Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Trp Cys Ser Ile Asp Trp Glu Gln Val Cys Leu Leu Gln 
    50                  55                  60                  


Arg Leu Gly Ala Gly Gly Phe Gly Ser Val Tyr Lys Ala Thr Tyr Arg 
65                  70                  75                  80  


Gly Val Pro Val Ala Ile Lys Gln Val Asn Lys Cys Thr Lys Asn Arg 
                85                  90                  95      


Leu Ala Ser Arg Arg Ser Phe Trp Ala Glu Leu Asn Val Ala Arg Leu 
            100                 105                 110         


Arg His Asp Asn Ile Val Arg Val Val Ala Ala Ser Thr Arg Thr Pro 
        115                 120                 125             


Ala Gly Ser Asn Ser Leu Gly Thr Ile Ile Met Glu Phe Gly Gly Asn 
    130                 135                 140                 


Val Thr Leu His Gln Val Ile Tyr Gly Ala Ala Gly His Pro Glu Gly 
145                 150                 155                 160 


Asp Ala Gly Glu Pro His Cys Arg Thr Gly Gly Gln Leu Ser Leu Gly 
                165                 170                 175     


Lys Cys Leu Lys Tyr Ser Leu Asp Val Val Asn Gly Leu Leu Phe Leu 
            180                 185                 190         


His Ser Gln Ser Ile Val His Leu Asp Leu Lys Pro Ala Asn Ile Leu 
        195                 200                 205             


Ile Ser Glu Gln Asp Val Cys Lys Ile Ser Asp Phe Gly Cys Ser Glu 
    210                 215                 220                 


Lys Leu Glu Asp Leu Leu Cys Phe Gln Thr Pro Ser Tyr Pro Leu Gly 
225                 230                 235                 240 


Gly Thr Tyr Thr His Arg Ala Pro Glu Leu Leu Lys Gly Glu Gly Val 
                245                 250                 255     


Thr Pro Lys Ala Asp Ile Tyr Ser Phe Ala Ile Thr Leu Trp Gln Met 
            260                 265                 270         


Thr Thr Lys Gln Ala Pro Tyr Ser Gly Glu Arg Gln His Ile Leu Tyr 
        275                 280                 285             


Ala Val Val Ala Tyr Asp Leu Arg Pro Ser Leu Ser Ala Ala Val Phe 
    290                 295                 300                 


Glu Asp Ser Leu Pro Gly Gln Arg Leu Gly Asp Val Ile Gln Arg Cys 
305                 310                 315                 320 


Trp Arg Pro Ser Ala Ala Gln Arg Pro Ser Ala Arg Leu Leu Leu Val 
                325                 330                 335     


Asp Leu Thr Ser Leu Lys Ala Glu Leu Gly 
            340                 345     


<210>  3278
<211>  635
<212>  PRT
<213>  Homo sapiens

<400>  3278

Met Pro Ser Trp Ala Leu Phe Met Val Thr Ser Cys Leu Leu Leu Ala 
1               5                   10                  15      


Pro Gln Asn Leu Ala Gln Val Ser Ser Gln Asp Val Ser Leu Leu Ala 
            20                  25                  30          


Ser Asp Ser Glu Pro Leu Lys Cys Phe Ser Arg Thr Phe Glu Asp Leu 
        35                  40                  45              


Thr Cys Phe Trp Asp Glu Glu Glu Ala Ala Pro Ser Gly Thr Tyr Gln 
    50                  55                  60                  


Leu Leu Tyr Ala Tyr Pro Arg Glu Lys Pro Arg Ala Cys Pro Leu Ser 
65                  70                  75                  80  


Ser Gln Ser Met Pro His Phe Gly Thr Arg Tyr Val Cys Gln Phe Pro 
                85                  90                  95      


Asp Gln Glu Glu Val Arg Leu Phe Phe Pro Leu His Leu Trp Val Lys 
            100                 105                 110         


Asn Val Phe Leu Asn Gln Thr Arg Thr Gln Arg Val Leu Phe Val Asp 
        115                 120                 125             


Ser Val Gly Leu Pro Ala Pro Pro Ser Ile Ile Lys Ala Met Gly Gly 
    130                 135                 140                 


Ser Gln Pro Gly Glu Leu Gln Ile Ser Trp Glu Glu Pro Ala Pro Glu 
145                 150                 155                 160 


Ile Ser Asp Phe Leu Arg Tyr Glu Leu Arg Tyr Gly Pro Arg Asp Pro 
                165                 170                 175     


Lys Asn Ser Thr Gly Pro Thr Val Ile Gln Leu Ile Ala Thr Glu Thr 
            180                 185                 190         


Cys Cys Pro Ala Leu Gln Arg Pro His Ser Ala Ser Ala Leu Asp Gln 
        195                 200                 205             


Ser Pro Cys Ala Gln Pro Thr Met Pro Trp Gln Asp Gly Pro Lys Gln 
    210                 215                 220                 


Thr Ser Pro Ser Arg Glu Ala Ser Ala Leu Thr Ala Glu Gly Gly Ser 
225                 230                 235                 240 


Cys Leu Ile Ser Gly Leu Gln Pro Gly Asn Ser Tyr Trp Leu Gln Leu 
                245                 250                 255     


Arg Ser Glu Pro Asp Gly Ile Ser Leu Gly Gly Ser Trp Gly Ser Trp 
            260                 265                 270         


Ser Leu Pro Val Thr Val Asp Leu Pro Gly Asp Ala Val Ala Leu Gly 
        275                 280                 285             


Leu Gln Cys Phe Thr Leu Asp Leu Lys Asn Val Thr Cys Gln Trp Gln 
    290                 295                 300                 


Gln Gln Asp His Ala Ser Ser Gln Gly Phe Phe Tyr His Ser Arg Ala 
305                 310                 315                 320 


Arg Cys Cys Pro Arg Asp Arg Tyr Pro Ile Trp Glu Asn Cys Glu Glu 
                325                 330                 335     


Glu Glu Lys Thr Asn Pro Gly Leu Gln Thr Pro Gln Phe Ser Arg Cys 
            340                 345                 350         


His Phe Lys Ser Arg Asn Asp Ser Ile Ile His Ile Leu Val Glu Val 
        355                 360                 365             


Thr Thr Ala Pro Gly Thr Val His Ser Tyr Leu Gly Ser Pro Phe Trp 
    370                 375                 380                 


Ile His Gln Ala Val Arg Leu Pro Thr Pro Asn Leu His Trp Arg Glu 
385                 390                 395                 400 


Ile Ser Ser Gly His Leu Glu Leu Glu Trp Gln His Pro Ser Ser Trp 
                405                 410                 415     


Ala Ala Gln Glu Thr Cys Tyr Gln Leu Arg Tyr Thr Gly Glu Gly His 
            420                 425                 430         


Gln Asp Trp Lys Val Leu Glu Pro Pro Leu Gly Ala Arg Gly Gly Thr 
        435                 440                 445             


Leu Glu Leu Arg Pro Arg Ser Arg Tyr Arg Leu Gln Leu Arg Ala Arg 
    450                 455                 460                 


Leu Asn Gly Pro Thr Tyr Gln Gly Pro Trp Ser Ser Trp Ser Asp Pro 
465                 470                 475                 480 


Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile Ser Leu Val Thr 
                485                 490                 495     


Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu 
            500                 505                 510         


Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu 
        515                 520                 525             


Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg 
    530                 535                 540                 


Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys 
545                 550                 555                 560 


Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu 
                565                 570                 575     


Arg Thr Pro Leu Pro Leu Cys Ser Ser Gln Ala Gln Met Asp Tyr Arg 
            580                 585                 590         


Arg Leu Gln Pro Ser Cys Leu Gly Thr Met Pro Leu Ser Val Cys Pro 
        595                 600                 605             


Pro Met Ala Glu Ser Gly Ser Cys Cys Thr Thr His Ile Ala Asn His 
    610                 615                 620                 


Ser Tyr Leu Pro Leu Ser Tyr Trp Gln Gln Pro 
625                 630                 635 


<210>  3279
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  3279

Met Ala Ala Val Ala Ala Ala Ser Ala Glu Leu Leu Ile Ile Gly Trp 
1               5                   10                  15      


Tyr Ile Phe Arg Val Leu Leu Gln Val Phe Leu Glu Cys Cys Ile Tyr 
            20                  25                  30          


Trp Val Gly Phe Ala Phe Arg Asn Pro Pro Gly Thr Gln Pro Ile Ala 
        35                  40                  45              


Arg Ser Glu Val Phe Arg Tyr Ser Leu Gln Lys Leu Ala Tyr Thr Val 
    50                  55                  60                  


Ser Arg Thr Gly Arg Gln Val Leu Gly Glu Arg Arg Gln Arg Ala Pro 
65                  70                  75                  80  


Asn 
    


<210>  3280
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  3280

Met Arg Cys Ala Leu Ala Leu Ser Ala Leu Leu Leu Leu Leu Ser Thr 
1               5                   10                  15      


Pro Pro Leu Leu Pro Ser Ser Pro Ser Pro Ser Pro Ser Pro Ser Gln 
            20                  25                  30          


Asn Ala Thr Gln Thr Thr Thr Asp Ser Ser Asn Lys Thr Ala Pro Thr 
        35                  40                  45              


Pro Ala Ser Ser Val Thr Ile Met Ala Thr Asp Thr Ala Gln Gln Ser 
    50                  55                  60                  


Thr Val Pro Thr Ser Lys Ala Asn Glu Ile Leu Ala Ser Val Lys Ala 
65                  70                  75                  80  


Thr Thr Leu Gly Val Ser Ser Asp Ser Pro Gly Thr Thr Thr Leu Ala 
                85                  90                  95      


Gln Gln Val Ser Gly Pro Val Asn Thr Thr Val Ala Arg Gly Gly Gly 
            100                 105                 110         


Ser Gly Asn Pro Thr Thr Thr Ile Glu Ser Pro Lys Ser Thr Lys Ser 
        115                 120                 125             


Ala Asp Thr Thr Thr Val Ala Thr Ser Thr Ala Thr Ala Lys Pro Asn 
    130                 135                 140                 


Thr Thr Ser Ser Gln Asn Gly Ala Glu Asp Thr Thr Asn Ser Gly Gly 
145                 150                 155                 160 


Lys Ser Ser His Ser Val Thr Thr Asp Leu Thr Ser Thr Lys Ala Glu 
                165                 170                 175     


His Leu Thr Thr Pro His Pro Thr Ser Pro Leu Ser Pro Arg Gln Pro 
            180                 185                 190         


Thr Ser Thr His Pro Val Ala Thr Pro Thr Ser Ser Gly His Asp His 
        195                 200                 205             


Leu Met Lys Ile Ser Ser Ser Ser Ser Thr Val Ala Ile Pro Gly Tyr 
    210                 215                 220                 


Thr Phe Thr Ser Pro Gly Met Thr Thr Thr Leu Pro Ser Ser Val Ile 
225                 230                 235                 240 


Ser Gln Arg Thr Gln Gln Thr Ser Ser Gln Met Pro Ala Ser Ser Thr 
                245                 250                 255     


Ala Pro Ser Ser Gln Glu Thr Val Gln Pro Thr Ser Pro Ala Thr Ala 
            260                 265                 270         


Leu Arg Thr Pro Thr Leu Pro Glu Thr Met Ser Ser Ser Pro Thr Ala 
        275                 280                 285             


Ala Ser Thr Thr His Arg Tyr Pro Lys Thr Pro Ser Pro Thr Val Ala 
    290                 295                 300                 


His Glu Ser Asn Trp Ala Lys Cys Glu Asp Leu Glu Thr Gln Thr Gln 
305                 310                 315                 320 


Ser Glu Lys Gln Leu Val Leu Asn Leu Thr Gly Asn Thr Leu Cys Ala 
                325                 330                 335     


Gly Gly Ala Ser Asp Glu Lys Leu Ile Ser Leu Ile Cys Arg Ala Val 
            340                 345                 350         


Lys Ala Thr Phe Asn Pro Ala Gln Asp Lys Cys Gly Ile Arg Leu Ala 
        355                 360                 365             


Ser Val Pro Gly Ser Gln Thr Val Val Val Lys Glu Ile Thr Ile His 
    370                 375                 380                 


Thr Lys Leu Pro Ala Lys Asp Val Tyr Glu Arg Leu Lys Asp Lys Trp 
385                 390                 395                 400 


Asp Glu Leu Lys Glu Ala Gly Val Ser Asp Met Lys Leu Gly Asp Gln 
                405                 410                 415     


Gly Pro Pro Glu Glu Ala Glu Asp Arg Phe Ser Met Pro Leu Ile Ile 
            420                 425                 430         


Thr Ile Val Cys Met Ala Ser Phe Leu Leu Leu Val Ala Ala Leu Tyr 
        435                 440                 445             


Gly Cys Cys His Gln Arg Leu Ser Gln Arg Lys Asp Gln Gln Arg Leu 
    450                 455                 460                 


Thr Glu Glu Leu Gln Thr Val Glu Asn Gly Tyr His Asp Asn Pro Thr 
465                 470                 475                 480 


Leu Glu Val Met Glu Thr Ser Ser Glu Met Gln Glu Lys Lys Val Val 
                485                 490                 495     


Ser Leu Asn Gly Glu Leu Gly Asp Ser Trp Ile Val Pro Leu Asp Asn 
            500                 505                 510         


Leu Thr Lys Asp Asp Leu Asp Glu Glu Glu Asp Thr His Leu 
        515                 520                 525     


<210>  3281
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  3281

Met Trp Arg Ser Leu Gly Leu Ala Leu Ala Leu Cys Leu Leu Pro Ser 
1               5                   10                  15      


Gly Gly Thr Glu Ser Gln Asp Gln Ser Ser Leu Cys Lys Gln Pro Pro 
            20                  25                  30          


Ala Trp Ser Ile Arg Asp Gln Asp Pro Met Leu Asn Ser Asn Gly Ser 
        35                  40                  45              


Val Thr Val Val Ala Leu Leu Gln Ala Ser Tyr Leu Cys Ile Leu Gln 
    50                  55                  60                  


Ala Ser Lys Leu Glu Asp Leu Arg Val Lys Leu Lys Lys Glu Gly Tyr 
65                  70                  75                  80  


Ser Asn Ile Ser Tyr Ile Val Val Asn His Gln Gly Ile Ser Ser Arg 
                85                  90                  95      


Leu Lys Tyr Thr His Leu Lys Asn Lys Val Ser Glu His Ile Pro Val 
            100                 105                 110         


Tyr Gln Gln Glu Glu Asn Gln Thr Asp Val Trp Thr Leu Leu Asn Gly 
        115                 120                 125             


Ser Lys Asp Asp Phe Leu Ile Tyr Asp Arg Cys Gly Arg Leu Val Tyr 
    130                 135                 140                 


His Leu Gly Leu Pro Phe Ser Phe Leu Thr Phe Pro Tyr Val Glu Glu 
145                 150                 155                 160 


Ala Ile Lys Ile Ala Tyr Cys Glu Lys Lys Cys Gly Asn Cys Ser Leu 
                165                 170                 175     


Thr Thr Leu Lys Asp Glu Asp Phe Cys Lys Arg Val Ser Leu Ala Thr 
            180                 185                 190         


Val Asp Lys Thr Val Glu Thr Pro Ser Pro His Tyr His His Glu His 
        195                 200                 205             


His His Asn His Gly His Gln His Leu Gly Ser Ser Glu Leu Ser Glu 
    210                 215                 220                 


Asn Gln Gln Pro Gly Ala Pro Asn Ala Pro Thr His Pro Ala Pro Pro 
225                 230                 235                 240 


Gly Leu His His His His Lys His Lys Gly Gln His Arg Gln Gly His 
                245                 250                 255     


Pro Glu Asn Arg Asp Met Pro Ala Ser Glu Asp Leu Gln Asp Leu Gln 
            260                 265                 270         


Lys Lys Leu Cys Arg Lys Arg Cys Ile Asn Gln Leu Leu Cys Lys Leu 
        275                 280                 285             


Pro Thr Asp Ser Glu Leu Ala Pro Arg Ser Cys Cys His Cys Arg His 
    290                 295                 300                 


Leu Ile Phe Glu Lys Thr Gly Ser Ala Ile Thr Gln Cys Lys Glu Asn 
305                 310                 315                 320 


Leu Pro Ser Leu Cys Ser Gln Gly Leu Arg Ala Glu Glu Asn Ile Thr 
                325                 330                 335     


Glu Ser Cys Gln Arg Leu Pro Pro Ala Ala Gln Ile Ser Gln Gln Leu 
            340                 345                 350         


Ile Pro Thr Glu Ala Ser Ala Ser Arg Lys Asn Gln Ala Lys Lys Glu 
        355                 360                 365             


Pro Ser Asn 
    370     


<210>  3282
<211>  679
<212>  PRT
<213>  Homo sapiens

<400>  3282

Met Ala Thr Leu Ile Thr Ser Thr Thr Ala Ala Thr Ala Ala Ser Gly 
1               5                   10                  15      


Pro Leu Val Asp Tyr Leu Trp Met Leu Ile Leu Gly Phe Ile Ile Ala 
            20                  25                  30          


Phe Val Leu Ala Phe Ser Val Gly Ala Asn Asp Val Ala Asn Ser Phe 
        35                  40                  45              


Gly Thr Ala Val Gly Ser Gly Val Val Thr Leu Lys Gln Ala Cys Ile 
    50                  55                  60                  


Leu Ala Ser Ile Phe Glu Thr Val Gly Ser Val Leu Leu Gly Ala Lys 
65                  70                  75                  80  


Val Ser Glu Thr Ile Arg Lys Gly Leu Ile Asp Val Glu Met Tyr Asn 
                85                  90                  95      


Ser Thr Gln Gly Leu Leu Met Ala Gly Ser Val Ser Ala Met Phe Gly 
            100                 105                 110         


Ser Ala Val Trp Gln Leu Val Ala Ser Phe Leu Lys Leu Pro Ile Ser 
        115                 120                 125             


Gly Thr His Cys Ile Val Gly Ala Thr Ile Gly Phe Ser Leu Val Ala 
    130                 135                 140                 


Lys Gly Gln Glu Gly Val Lys Trp Ser Glu Leu Ile Lys Ile Val Met 
145                 150                 155                 160 


Ser Trp Phe Val Ser Pro Leu Leu Ser Gly Ile Met Ser Gly Ile Leu 
                165                 170                 175     


Phe Phe Leu Val Arg Ala Phe Ile Leu His Lys Ala Asp Pro Val Pro 
            180                 185                 190         


Asn Gly Leu Arg Ala Leu Pro Val Phe Tyr Ala Cys Thr Val Gly Ile 
        195                 200                 205             


Asn Leu Phe Ser Ile Met Tyr Thr Gly Ala Pro Leu Leu Gly Phe Asp 
    210                 215                 220                 


Lys Leu Pro Leu Trp Gly Thr Ile Leu Ile Ser Val Gly Cys Ala Val 
225                 230                 235                 240 


Phe Cys Ala Leu Ile Val Trp Phe Phe Val Cys Pro Arg Met Lys Arg 
                245                 250                 255     


Lys Ile Glu Arg Glu Ile Lys Cys Ser Pro Ser Glu Ser Pro Leu Met 
            260                 265                 270         


Glu Lys Lys Asn Ser Leu Lys Glu Asp His Glu Glu Thr Lys Leu Ser 
        275                 280                 285             


Val Gly Asp Ile Glu Asn Lys His Pro Val Ser Glu Val Gly Pro Ala 
    290                 295                 300                 


Thr Val Pro Leu Gln Ala Val Val Glu Glu Arg Thr Val Ser Phe Lys 
305                 310                 315                 320 


Leu Gly Asp Leu Glu Glu Ala Pro Glu Arg Glu Arg Leu Pro Ser Val 
                325                 330                 335     


Asp Leu Lys Glu Glu Thr Ser Ile Asp Ser Thr Val Asn Gly Ala Val 
            340                 345                 350         


Gln Leu Pro Asn Gly Asn Leu Val Gln Phe Ser Gln Ala Val Ser Asn 
        355                 360                 365             


Gln Ile Asn Ser Ser Gly His Tyr Gln Tyr His Thr Val His Lys Asp 
    370                 375                 380                 


Ser Gly Leu Tyr Lys Glu Leu Leu His Lys Leu His Leu Ala Lys Val 
385                 390                 395                 400 


Gly Asp Cys Met Gly Asp Ser Gly Asp Lys Pro Leu Arg Arg Asn Asn 
                405                 410                 415     


Ser Tyr Thr Ser Tyr Thr Met Ala Ile Cys Gly Met Pro Leu Asp Ser 
            420                 425                 430         


Phe Arg Ala Lys Glu Gly Glu Gln Lys Gly Glu Glu Met Glu Lys Leu 
        435                 440                 445             


Thr Trp Pro Asn Ala Asp Ser Lys Lys Arg Ile Arg Met Asp Ser Tyr 
    450                 455                 460                 


Thr Ser Tyr Cys Asn Ala Val Ser Asp Leu His Ser Ala Ser Glu Ile 
465                 470                 475                 480 


Asp Met Ser Val Lys Ala Glu Met Gly Leu Gly Asp Arg Lys Gly Ser 
                485                 490                 495     


Asn Gly Ser Leu Glu Glu Trp Tyr Asp Gln Asp Lys Pro Glu Val Ser 
            500                 505                 510         


Leu Leu Phe Gln Phe Leu Gln Ile Leu Thr Ala Cys Phe Gly Ser Phe 
        515                 520                 525             


Ala His Gly Gly Asn Asp Val Ser Asn Ala Ile Gly Pro Leu Val Ala 
    530                 535                 540                 


Leu Tyr Leu Val Tyr Asp Thr Gly Asp Val Ser Ser Lys Val Ala Thr 
545                 550                 555                 560 


Pro Ile Trp Leu Leu Leu Tyr Gly Gly Val Gly Ile Cys Val Gly Leu 
                565                 570                 575     


Trp Val Trp Gly Arg Arg Val Ile Gln Thr Met Gly Lys Asp Leu Thr 
            580                 585                 590         


Pro Ile Thr Pro Ser Ser Gly Phe Ser Ile Glu Leu Ala Ser Ala Leu 
        595                 600                 605             


Thr Val Val Ile Ala Ser Asn Ile Gly Leu Pro Ile Ser Thr Thr His 
    610                 615                 620                 


Cys Lys Val Gly Ser Val Val Ser Val Gly Trp Leu Arg Ser Lys Lys 
625                 630                 635                 640 


Ala Val Asp Trp Arg Leu Phe Arg Asn Ile Phe Met Ala Trp Phe Val 
                645                 650                 655     


Thr Val Pro Ile Ser Gly Val Ile Ser Ala Ala Ile Met Ala Ile Phe 
            660                 665                 670         


Arg Tyr Val Ile Leu Arg Met 
        675                 


<210>  3283
<211>  1138
<212>  PRT
<213>  Homo sapiens

<400>  3283

Met Val Trp Arg Val Pro Pro Phe Leu Leu Pro Ile Leu Phe Leu Ala 
1               5                   10                  15      


Ser His Val Gly Ala Ala Val Asp Leu Thr Leu Leu Ala Asn Leu Arg 
            20                  25                  30          


Leu Thr Asp Pro Gln Arg Phe Phe Leu Thr Cys Val Ser Gly Glu Ala 
        35                  40                  45              


Gly Ala Gly Arg Gly Ser Asp Ala Trp Gly Pro Pro Leu Leu Leu Glu 
    50                  55                  60                  


Lys Asp Asp Arg Ile Val Arg Thr Pro Pro Gly Pro Pro Leu Arg Leu 
65                  70                  75                  80  


Ala Arg Asn Gly Ser His Gln Val Thr Leu Arg Gly Phe Ser Lys Pro 
                85                  90                  95      


Ser Asp Leu Val Gly Val Phe Ser Cys Val Gly Gly Ala Gly Ala Arg 
            100                 105                 110         


Arg Thr Arg Val Ile Tyr Val His Asn Ser Pro Gly Ala His Leu Leu 
        115                 120                 125             


Pro Asp Lys Val Thr His Thr Val Asn Lys Gly Asp Thr Ala Val Leu 
    130                 135                 140                 


Ser Ala Arg Val His Lys Glu Lys Gln Thr Asp Val Ile Trp Lys Ser 
145                 150                 155                 160 


Asn Gly Ser Tyr Phe Tyr Thr Leu Asp Trp His Glu Ala Gln Asp Gly 
                165                 170                 175     


Arg Phe Leu Leu Gln Leu Pro Asn Val Gln Pro Pro Ser Ser Gly Ile 
            180                 185                 190         


Tyr Ser Ala Thr Tyr Leu Glu Ala Ser Pro Leu Gly Ser Ala Phe Phe 
        195                 200                 205             


Arg Leu Ile Val Arg Gly Cys Gly Ala Gly Arg Trp Gly Pro Gly Cys 
    210                 215                 220                 


Thr Lys Glu Cys Pro Gly Cys Leu His Gly Gly Val Cys His Asp His 
225                 230                 235                 240 


Asp Gly Glu Cys Val Cys Pro Pro Gly Phe Thr Gly Thr Arg Cys Glu 
                245                 250                 255     


Gln Ala Cys Arg Glu Gly Arg Phe Gly Gln Ser Cys Gln Glu Gln Cys 
            260                 265                 270         


Pro Gly Ile Ser Gly Cys Arg Gly Leu Thr Phe Cys Leu Pro Asp Pro 
        275                 280                 285             


Tyr Gly Cys Ser Cys Gly Ser Gly Trp Arg Gly Ser Gln Cys Gln Glu 
    290                 295                 300                 


Ala Cys Ala Pro Gly His Phe Gly Ala Asp Cys Arg Leu Gln Cys Gln 
305                 310                 315                 320 


Cys Gln Asn Gly Gly Thr Cys Asp Arg Phe Ser Gly Cys Val Cys Pro 
                325                 330                 335     


Ser Gly Trp His Gly Val His Cys Glu Lys Ser Asp Arg Ile Pro Gln 
            340                 345                 350         


Ile Leu Asn Met Ala Ser Glu Leu Glu Phe Asn Leu Glu Thr Met Pro 
        355                 360                 365             


Arg Ile Asn Cys Ala Ala Ala Gly Asn Pro Phe Pro Val Arg Gly Ser 
    370                 375                 380                 


Ile Glu Leu Arg Lys Pro Asp Gly Thr Val Leu Leu Ser Thr Lys Ala 
385                 390                 395                 400 


Ile Val Glu Pro Glu Lys Thr Thr Ala Glu Phe Glu Val Pro Arg Leu 
                405                 410                 415     


Val Leu Ala Asp Ser Gly Phe Trp Glu Cys Arg Val Ser Thr Ser Gly 
            420                 425                 430         


Gly Gln Asp Ser Arg Arg Phe Lys Val Asn Val Lys Val Pro Pro Val 
        435                 440                 445             


Pro Leu Ala Ala Pro Arg Leu Leu Thr Lys Gln Ser Arg Gln Leu Val 
    450                 455                 460                 


Val Ser Pro Leu Val Ser Phe Ser Gly Asp Gly Pro Ile Ser Thr Val 
465                 470                 475                 480 


Arg Leu His Tyr Arg Pro Gln Asp Ser Thr Met Asp Trp Ser Thr Ile 
                485                 490                 495     


Val Val Asp Pro Ser Glu Asn Val Thr Leu Met Asn Leu Arg Pro Lys 
            500                 505                 510         


Thr Gly Tyr Ser Val Arg Val Gln Leu Ser Arg Pro Gly Glu Gly Gly 
        515                 520                 525             


Glu Gly Ala Trp Gly Pro Pro Thr Leu Met Thr Thr Asp Cys Pro Glu 
    530                 535                 540                 


Pro Leu Leu Gln Pro Trp Leu Glu Gly Trp His Val Glu Gly Thr Asp 
545                 550                 555                 560 


Arg Leu Arg Val Ser Trp Ser Leu Pro Leu Val Pro Gly Pro Leu Val 
                565                 570                 575     


Gly Asp Gly Phe Leu Leu Arg Leu Trp Asp Gly Thr Arg Gly Gln Glu 
            580                 585                 590         


Arg Arg Glu Asn Val Ser Ser Pro Gln Ala Arg Thr Ala Leu Leu Thr 
        595                 600                 605             


Gly Leu Thr Pro Gly Thr His Tyr Gln Leu Asp Val Gln Leu Tyr His 
    610                 615                 620                 


Cys Thr Leu Leu Gly Pro Ala Ser Pro Pro Ala His Val Leu Leu Pro 
625                 630                 635                 640 


Pro Ser Gly Pro Pro Ala Pro Arg His Leu His Ala Gln Ala Leu Ser 
                645                 650                 655     


Asp Ser Glu Ile Gln Leu Thr Trp Lys His Pro Glu Ala Leu Pro Gly 
            660                 665                 670         


Pro Ile Ser Lys Tyr Val Val Glu Val Gln Val Ala Gly Gly Ala Gly 
        675                 680                 685             


Asp Pro Leu Trp Ile Asp Val Asp Arg Pro Glu Glu Thr Ser Thr Ile 
    690                 695                 700                 


Ile Arg Gly Leu Asn Ala Ser Thr Arg Tyr Leu Phe Arg Met Arg Ala 
705                 710                 715                 720 


Ser Ile Gln Gly Leu Gly Asp Trp Ser Asn Thr Val Glu Glu Ser Thr 
                725                 730                 735     


Leu Gly Asn Gly Leu Gln Ala Glu Gly Pro Val Gln Glu Ser Arg Ala 
            740                 745                 750         


Ala Glu Glu Gly Leu Asp Gln Gln Leu Ile Leu Ala Val Val Gly Ser 
        755                 760                 765             


Val Ser Ala Thr Cys Leu Thr Ile Leu Ala Ala Leu Leu Thr Leu Val 
    770                 775                 780                 


Cys Ile Arg Arg Ser Cys Leu His Arg Arg Arg Thr Phe Thr Tyr Gln 
785                 790                 795                 800 


Ser Gly Ser Gly Glu Glu Thr Ile Leu Gln Phe Ser Ser Gly Thr Leu 
                805                 810                 815     


Thr Leu Thr Arg Arg Pro Lys Leu Gln Pro Glu Pro Leu Ser Tyr Pro 
            820                 825                 830         


Val Leu Glu Trp Glu Asp Ile Thr Phe Glu Asp Leu Ile Gly Glu Gly 
        835                 840                 845             


Asn Phe Gly Gln Val Ile Arg Ala Met Ile Lys Lys Asp Gly Leu Lys 
    850                 855                 860                 


Met Asn Ala Ala Ile Lys Met Leu Lys Glu Tyr Ala Ser Glu Asn Asp 
865                 870                 875                 880 


His Arg Asp Phe Ala Gly Glu Leu Glu Val Leu Cys Lys Leu Gly His 
                885                 890                 895     


His Pro Asn Ile Ile Asn Leu Leu Gly Ala Cys Lys Asn Arg Gly Tyr 
            900                 905                 910         


Leu Tyr Ile Ala Ile Glu Tyr Ala Pro Tyr Gly Asn Leu Leu Asp Phe 
        915                 920                 925             


Leu Arg Lys Ser Arg Val Leu Glu Thr Asp Pro Ala Phe Ala Arg Glu 
    930                 935                 940                 


His Gly Thr Ala Ser Thr Leu Ser Ser Arg Gln Leu Leu Arg Phe Ala 
945                 950                 955                 960 


Ser Asp Ala Ala Asn Gly Met Gln Tyr Leu Ser Glu Lys Gln Phe Ile 
                965                 970                 975     


His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Gly Glu Asn Leu Ala 
            980                 985                 990         


Ser Lys Ile Ala Asp Phe Gly Leu  Ser Arg Gly Glu Glu  Val Tyr Val 
        995                 1000                 1005             


Lys Lys  Thr Met Gly Arg Leu  Pro Val Arg Trp Met  Ala Ile Glu 
    1010                 1015                 1020             


Ser Leu  Asn Tyr Ser Val Tyr  Thr Thr Lys Ser Asp  Val Trp Ser 
    1025                 1030                 1035             


Phe Gly  Val Leu Leu Trp Glu  Ile Val Ser Leu Gly  Gly Thr Pro 
    1040                 1045                 1050             


Tyr Cys  Gly Met Thr Cys Ala  Glu Leu Tyr Glu Lys  Leu Pro Gln 
    1055                 1060                 1065             


Gly Tyr  Arg Met Glu Gln Pro  Arg Asn Cys Asp Asp  Glu Val Tyr 
    1070                 1075                 1080             


Glu Leu  Met Arg Gln Cys Trp  Arg Asp Arg Pro Tyr  Glu Arg Pro 
    1085                 1090                 1095             


Pro Phe  Ala Gln Ile Ala Leu  Gln Leu Gly Arg Met  Leu Glu Ala 
    1100                 1105                 1110             


Arg Lys  Ala Tyr Val Asn Met  Ser Leu Phe Glu Asn  Phe Thr Tyr 
    1115                 1120                 1125             


Ala Gly  Ile Asp Ala Thr Ala  Glu Glu Ala 
    1130                 1135             


<210>  3284
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  3284

Met Gly Leu Trp Ala Leu Leu Pro Gly Trp Val Ser Ala Thr Leu Leu 
1               5                   10                  15      


Leu Ala Leu Ala Ala Leu Pro Ala Ala Leu Ala Ala Asn Ser Ser Gly 
            20                  25                  30          


Arg Trp Trp Gly Ile Val Asn Val Ala Ser Ser Thr Asn Leu Leu Thr 
        35                  40                  45              


Asp Ser Lys Ser Leu Gln Leu Val Leu Glu Pro Ser Leu Gln Leu Leu 
    50                  55                  60                  


Ser Arg Lys Gln Arg Arg Leu Ile Arg Gln Asn Pro Gly Ile Leu His 
65                  70                  75                  80  


Ser Val Ser Gly Gly Leu Gln Ser Ala Val Arg Glu Cys Lys Trp Gln 
                85                  90                  95      


Phe Arg Asn Arg Arg Trp Asn Cys Pro Thr Ala Pro Gly Pro His Leu 
            100                 105                 110         


Phe Gly Lys Ile Val Asn Arg Gly Cys Arg Glu Thr Ala Phe Ile Phe 
        115                 120                 125             


Ala Ile Thr Ser Ala Gly Val Thr His Ser Val Ala Arg Ser Cys Ser 
    130                 135                 140                 


Glu Gly Ser Ile Glu Ser Cys Thr Cys Asp Tyr Arg Arg Arg Gly Pro 
145                 150                 155                 160 


Gly Gly Pro Asp Trp His Trp Gly Gly Cys Ser Asp Asn Ile Asp Phe 
                165                 170                 175     


Gly Arg Leu Phe Gly Arg Glu Phe Val Asp Ser Gly Glu Lys Gly Arg 
            180                 185                 190         


Asp Leu Arg Phe Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Thr 
        195                 200                 205             


Thr Val Phe Ser Glu Met Arg Gln Glu Cys Lys Cys His Gly Met Ser 
    210                 215                 220                 


Gly Ser Cys Thr Val Arg Thr Cys Trp Met Arg Leu Pro Thr Leu Arg 
225                 230                 235                 240 


Ala Val Gly Asp Val Leu Arg Asp Arg Phe Asp Gly Ala Ser Arg Val 
                245                 250                 255     


Leu Tyr Gly Asn Arg Gly Ser Asn Arg Ala Ser Arg Ala Glu Leu Leu 
            260                 265                 270         


Arg Leu Glu Pro Glu Asp Pro Ala His Lys Pro Pro Ser Pro His Asp 
        275                 280                 285             


Leu Val Tyr Phe Glu Lys Ser Pro Asn Phe Cys Thr Tyr Ser Gly Arg 
    290                 295                 300                 


Leu Gly Thr Ala Gly Thr Ala Gly Arg Ala Cys Asn Ser Ser Ser Pro 
305                 310                 315                 320 


Ala Leu Asp Gly Cys Glu Leu Leu Cys Cys Gly Arg Gly His Arg Thr 
                325                 330                 335     


Arg Thr Gln Arg Val Thr Glu Arg Cys Asn Cys Thr Phe His Trp Cys 
            340                 345                 350         


Cys His Val Ser Cys Arg Asn Cys Thr His Thr Arg Val Leu His Glu 
        355                 360                 365             


Cys Leu 
    370 


<210>  3285
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  3285

Met Phe Arg Phe Met Arg Asp Val Glu Pro Glu Asp Pro Met Phe Leu 
1               5                   10                  15      


Met Asp Pro Phe Ala Ile His Arg Gln His Met Ser Arg Met Leu Ser 
            20                  25                  30          


Gly Gly Phe Gly Tyr Ser Pro Phe Leu Ser Ile Thr Asp Gly Asn Met 
        35                  40                  45              


Pro Gly Thr Arg Pro Ala Ser Arg Arg Met Gln Gln Ala Gly Ala Val 
    50                  55                  60                  


Ser Pro Phe Gly Met Leu Gly Met Ser Gly Gly Phe Met Asp Met Phe 
65                  70                  75                  80  


Gly Met Met Asn Asp Met Ile Gly Asn Met Glu His Met Thr Ala Gly 
                85                  90                  95      


Gly Asn Cys Gln Thr Phe Ser Ser Ser Thr Val Ile Ser Tyr Ser Asn 
            100                 105                 110         


Thr Gly Asp Gly Ala Pro Lys Val Tyr Gln Glu Thr Ser Glu Met Arg 
        115                 120                 125             


Ser Ala Pro Gly Gly Ile Arg Glu Thr Arg Arg Thr Val Arg Asp Ser 
    130                 135                 140                 


Asp Ser Gly Leu Glu Gln Met Ser Ile Gly His His Ile Arg Asp Arg 
145                 150                 155                 160 


Ala His Ile Leu Gln Arg Ser Arg Asn His Arg Thr Gly Asp Gln Glu 
                165                 170                 175     


Glu Arg Gln Asp Tyr Ile Asn Leu Asp Glu Ser Glu Ala Ala Ala Phe 
            180                 185                 190         


Asp Asp Glu Trp Arg Arg Glu Thr Ser Arg Phe Arg Gln Gln Arg Pro 
        195                 200                 205             


Leu Glu Phe Arg Arg Leu Glu Ser Ser Gly Ala Gly Gly Arg Arg Ala 
    210                 215                 220                 


Glu Gly Pro Pro Arg Leu Ala Ile Gln Gly Pro Glu Asp Ser Pro Ser 
225                 230                 235                 240 


Arg Gln Ser Arg Arg Tyr Asp Trp 
                245             


<210>  3286
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  3286

Met Cys Pro Gln Leu Ala Gly Ala Gly Ser Met Gly Ser Pro Gly Ala 
1               5                   10                  15      


Thr Thr Gly Trp Gly Leu Leu Asp Tyr Lys Thr Glu Lys Tyr Val Met 
            20                  25                  30          


Thr Arg Asn Trp Arg Val Gly Ala Leu Gln Arg Leu Leu Gln Phe Gly 
        35                  40                  45              


Ile Val Val Tyr Val Val Gly Trp Ala Leu Leu Ala Lys Lys Gly Tyr 
    50                  55                  60                  


Gln Glu Arg Asp Leu Glu Pro Gln Phe Ser Ile Ile Thr Lys Leu Lys 
65                  70                  75                  80  


Gly Val Ser Val Thr Gln Ile Lys Glu Leu Gly Asn Arg Leu Trp Asp 
                85                  90                  95      


Val Ala Asp Phe Val Lys Pro Pro Gln Gly Glu Asn Val Phe Phe Leu 
            100                 105                 110         


Val Thr Asn Phe Leu Val Thr Pro Ala Gln Val Gln Gly Arg Cys Pro 
        115                 120                 125             


Glu His Pro Ser Val Pro Leu Ala Asn Cys Trp Val Asp Glu Asp Cys 
    130                 135                 140                 


Pro Glu Gly Glu Gly Gly Thr His Ser His Gly Val Lys Thr Gly Gln 
145                 150                 155                 160 


Cys Val Val Phe Asn Gly Thr His Arg Thr Cys Glu Ile Trp Ser Trp 
                165                 170                 175     


Cys Pro Val Glu Ser Gly Val Val Pro Ser Arg Pro Leu Leu Ala Gln 
            180                 185                 190         


Ala Gln Asn Phe Thr Leu Phe Ile Lys Asn Thr Val Thr Phe Ser Lys 
        195                 200                 205             


Phe Asn Phe Ser Lys Ser Asn Ala Leu Glu Thr Trp Asp Pro Thr Tyr 
    210                 215                 220                 


Phe Lys His Cys Arg Tyr Glu Pro Gln Phe Ser Pro Tyr Cys Pro Val 
225                 230                 235                 240 


Phe Arg Ile Gly Asp Leu Val Ala Lys Ala Gly Gly Thr Phe Glu Asp 
                245                 250                 255     


Leu Ala Leu Leu Gly Gly Ser Val Gly Ile Arg Val His Trp Asp Cys 
            260                 265                 270         


Asp Leu Asp Thr Gly Asp Ser Gly Cys Trp Pro His Tyr Ser Phe Gln 
        275                 280                 285             


Leu Gln Glu Lys Ser Tyr Asn Phe Arg Thr Ala Thr His Trp Trp Glu 
    290                 295                 300                 


Gln Pro Gly Val Glu Ala Arg Thr Leu Leu Lys Leu Tyr Gly Ile Arg 
305                 310                 315                 320 


Phe Asp Ile Leu Val Thr Gly Gln Ala Gly Lys Phe Gly Leu Ile Pro 
                325                 330                 335     


Thr Ala Val Thr Leu Gly Thr Gly Ala Ala Trp Leu Gly Val Val Thr 
            340                 345                 350         


Phe Phe Cys Asp Leu Leu Leu Leu Tyr Val Asp Arg Glu Ala His Phe 
        355                 360                 365             


Tyr Trp Arg Thr Lys Tyr Glu Glu Ala Lys Ala Pro Lys Ala Thr Ala 
    370                 375                 380                 


Asn Ser Val Trp Arg Glu Leu Ala Leu Ala Ser Gln Ala Arg Leu Ala 
385                 390                 395                 400 


Glu Cys Leu Arg Arg Ser Ser Ala Pro Ala Pro Thr Ala Thr Ala Ala 
                405                 410                 415     


Gly Ser Gln Thr Gln Thr Pro Gly Trp Pro Cys Pro Ser Ser Asp Thr 
            420                 425                 430         


His Leu Pro Thr His Ser Gly Ser Leu 
        435                 440     


<210>  3287
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  3287

Met Asp Phe Trp Leu Trp Pro Leu Tyr Phe Leu Pro Val Ser Gly Ala 
1               5                   10                  15      


Leu Arg Ile Leu Pro Glu Val Lys Val Glu Gly Glu Leu Gly Gly Ser 
            20                  25                  30          


Val Thr Ile Lys Cys Pro Leu Pro Glu Met His Val Arg Ile Tyr Leu 
        35                  40                  45              


Cys Arg Glu Met Ala Gly Ser Gly Thr Cys Gly Thr Val Val Ser Thr 
    50                  55                  60                  


Thr Asn Phe Ile Lys Ala Glu Tyr Lys Gly Arg Val Thr Leu Lys Gln 
65                  70                  75                  80  


Tyr Pro Arg Lys Asn Leu Phe Leu Val Glu Val Thr Gln Leu Thr Glu 
                85                  90                  95      


Ser Asp Ser Gly Val Tyr Ala Cys Gly Ala Gly Met Asn Thr Asp Arg 
            100                 105                 110         


Gly Lys Thr Gln Lys Val Thr Leu Asn Val His Ser Glu Tyr Glu Pro 
        115                 120                 125             


Ser Trp Glu Glu Gln Pro Met Pro Glu Thr Pro Lys Trp Phe His Leu 
    130                 135                 140                 


Pro Tyr Leu Phe Gln Met Pro Ala Tyr Ala Ser Ser Ser Lys Phe Val 
145                 150                 155                 160 


Thr Arg Val Thr Thr Pro Ala Gln Arg Gly Lys Val Pro Pro Val His 
                165                 170                 175     


His Ser Ser Pro Thr Thr Gln Ile Thr His Arg Pro Arg Val Ser Arg 
            180                 185                 190         


Ala Ser Ser Val Ala Gly Asp Lys Pro Arg Thr Phe Leu Pro Ser Thr 
        195                 200                 205             


Thr Ala Ser Lys Ile Ser Ala Leu Glu Gly Leu Leu Lys Pro Gln Thr 
    210                 215                 220                 


Pro Ser Tyr Asn His His Thr Arg Leu His Arg Gln Arg Ala Leu Asp 
225                 230                 235                 240 


Tyr Gly Ser Gln Ser Gly Arg Glu Gly Gln Gly Phe His Ile Leu Ile 
                245                 250                 255     


Pro Thr Ile Leu Gly Leu Phe Leu Leu Ala Leu Leu Gly Leu Val Val 
            260                 265                 270         


Lys Arg Ala Val Glu Arg Arg Lys Ala Leu Ser Arg Arg Ala Arg Arg 
        275                 280                 285             


Leu Ala Val Arg Met Arg Ala Leu Glu Ser Ser Gln Arg Pro Arg Gly 
    290                 295                 300                 


Ser Pro Arg Pro Arg Ser Gln Asn Asn Ile Tyr Ser Ala Cys Pro Arg 
305                 310                 315                 320 


Arg Ala Arg Gly Ala Asp Ala Ala Gly Thr Gly Glu Ala Pro Val Pro 
                325                 330                 335     


Gly Pro Gly Ala Pro Leu Pro Pro Ala Pro Leu Gln Val Ser Glu Ser 
            340                 345                 350         


Pro Trp Leu His Ala Pro Ser Leu Lys Thr Ser Cys Glu Tyr Val Ser 
        355                 360                 365             


Leu Tyr His Gln Pro Ala Ala Met Met Glu Asp Ser Asp Ser Asp Asp 
    370                 375                 380                 


Tyr Ile Asn Val Pro Ala 
385                 390 


<210>  3288
<211>  941
<212>  PRT
<213>  Homo sapiens

<400>  3288

Met Ala Ser Pro Arg Ser Ser Gly Gln Pro Gly Pro Pro Pro Pro Pro 
1               5                   10                  15      


Pro Pro Pro Pro Ala Arg Leu Leu Leu Leu Leu Leu Leu Pro Leu Leu 
            20                  25                  30          


Leu Pro Leu Ala Pro Gly Ala Trp Gly Trp Ala Arg Gly Ala Pro Arg 
        35                  40                  45              


Pro Pro Pro Ser Ser Pro Pro Leu Ser Ile Met Gly Leu Met Pro Leu 
    50                  55                  60                  


Thr Lys Glu Val Ala Lys Gly Ser Ile Gly Arg Gly Val Leu Pro Ala 
65                  70                  75                  80  


Val Glu Leu Ala Ile Glu Gln Ile Arg Asn Glu Ser Leu Leu Arg Pro 
                85                  90                  95      


Tyr Phe Leu Asp Leu Arg Leu Tyr Asp Thr Glu Cys Asp Asn Ala Lys 
            100                 105                 110         


Gly Leu Lys Ala Phe Tyr Asp Ala Ile Lys Tyr Gly Pro Asn His Leu 
        115                 120                 125             


Met Val Phe Gly Gly Val Cys Pro Ser Val Thr Ser Ile Ile Ala Glu 
    130                 135                 140                 


Ser Leu Gln Gly Trp Asn Leu Val Gln Leu Ser Phe Ala Ala Thr Thr 
145                 150                 155                 160 


Pro Val Leu Ala Asp Lys Lys Lys Tyr Pro Tyr Phe Phe Arg Thr Val 
                165                 170                 175     


Pro Ser Asp Asn Ala Val Asn Pro Ala Ile Leu Lys Leu Leu Lys His 
            180                 185                 190         


Tyr Gln Trp Lys Arg Val Gly Thr Leu Thr Gln Asp Val Gln Arg Phe 
        195                 200                 205             


Ser Glu Val Arg Asn Asp Leu Thr Gly Val Leu Tyr Gly Glu Asp Ile 
    210                 215                 220                 


Glu Ile Ser Asp Thr Glu Ser Phe Ser Asn Asp Pro Cys Thr Ser Val 
225                 230                 235                 240 


Lys Lys Leu Lys Gly Asn Asp Val Arg Ile Ile Leu Gly Gln Phe Asp 
                245                 250                 255     


Gln Asn Met Ala Ala Lys Val Phe Cys Cys Ala Tyr Glu Glu Asn Met 
            260                 265                 270         


Tyr Gly Ser Lys Tyr Gln Trp Ile Ile Pro Gly Trp Tyr Glu Pro Ser 
        275                 280                 285             


Trp Trp Glu Gln Val His Thr Glu Ala Asn Ser Ser Arg Cys Leu Arg 
    290                 295                 300                 


Lys Asn Leu Leu Ala Ala Met Glu Gly Tyr Ile Gly Val Asp Phe Glu 
305                 310                 315                 320 


Pro Leu Ser Ser Lys Gln Ile Lys Thr Ile Ser Gly Lys Thr Pro Gln 
                325                 330                 335     


Gln Tyr Glu Arg Glu Tyr Asn Asn Lys Arg Ser Gly Val Gly Pro Ser 
            340                 345                 350         


Lys Phe His Gly Tyr Ala Tyr Asp Gly Ile Trp Val Ile Ala Lys Thr 
        355                 360                 365             


Leu Gln Arg Ala Met Glu Thr Leu His Ala Ser Ser Arg His Gln Arg 
    370                 375                 380                 


Ile Gln Asp Phe Asn Tyr Thr Asp His Thr Leu Gly Arg Ile Ile Leu 
385                 390                 395                 400 


Asn Ala Met Asn Glu Thr Asn Phe Phe Gly Val Thr Gly Gln Val Val 
                405                 410                 415     


Phe Arg Asn Gly Glu Arg Met Gly Thr Ile Lys Phe Thr Gln Phe Gln 
            420                 425                 430         


Asp Ser Arg Glu Val Lys Val Gly Glu Tyr Asn Ala Val Ala Asp Thr 
        435                 440                 445             


Leu Glu Ile Ile Asn Asp Thr Ile Arg Phe Gln Gly Ser Glu Pro Pro 
    450                 455                 460                 


Lys Asp Lys Thr Ile Ile Leu Glu Gln Leu Arg Lys Ile Ser Leu Pro 
465                 470                 475                 480 


Leu Tyr Ser Ile Leu Ser Ala Leu Thr Ile Leu Gly Met Ile Met Ala 
                485                 490                 495     


Ser Ala Phe Leu Phe Phe Asn Ile Lys Asn Arg Asn Gln Lys Leu Ile 
            500                 505                 510         


Lys Met Ser Ser Pro Tyr Met Asn Asn Leu Ile Ile Leu Gly Gly Met 
        515                 520                 525             


Leu Ser Tyr Ala Ser Ile Phe Leu Phe Gly Leu Asp Gly Ser Phe Val 
    530                 535                 540                 


Ser Glu Lys Thr Phe Glu Thr Leu Cys Thr Val Arg Thr Trp Ile Leu 
545                 550                 555                 560 


Thr Val Gly Tyr Thr Thr Ala Phe Gly Ala Met Phe Ala Lys Thr Trp 
                565                 570                 575     


Arg Val His Ala Ile Phe Lys Asn Val Lys Met Lys Lys Lys Ile Ile 
            580                 585                 590         


Lys Asp Gln Lys Leu Leu Val Ile Val Gly Gly Met Leu Leu Ile Asp 
        595                 600                 605             


Leu Cys Ile Leu Ile Cys Trp Gln Ala Val Asp Pro Leu Arg Arg Thr 
    610                 615                 620                 


Val Glu Lys Tyr Ser Met Glu Pro Asp Pro Ala Gly Arg Asp Ile Ser 
625                 630                 635                 640 


Ile Arg Pro Leu Leu Glu His Cys Glu Asn Thr His Met Thr Ile Trp 
                645                 650                 655     


Leu Gly Ile Val Tyr Ala Tyr Lys Gly Leu Leu Met Leu Phe Gly Cys 
            660                 665                 670         


Phe Leu Ala Trp Glu Thr Arg Asn Val Ser Ile Pro Ala Leu Asn Asp 
        675                 680                 685             


Ser Lys Tyr Ile Gly Met Ser Val Tyr Asn Val Gly Ile Met Cys Ile 
    690                 695                 700                 


Ile Gly Ala Ala Val Ser Phe Leu Thr Arg Asp Gln Pro Asn Val Gln 
705                 710                 715                 720 


Phe Cys Ile Val Ala Leu Val Ile Ile Phe Cys Ser Thr Ile Thr Leu 
                725                 730                 735     


Cys Leu Val Phe Val Pro Lys Leu Ile Thr Leu Arg Thr Asn Pro Asp 
            740                 745                 750         


Ala Ala Thr Gln Asn Arg Arg Phe Gln Phe Thr Gln Asn Gln Lys Lys 
        755                 760                 765             


Glu Asp Ser Lys Thr Ser Thr Ser Val Thr Ser Val Asn Gln Ala Ser 
    770                 775                 780                 


Thr Ser Arg Leu Glu Gly Leu Gln Ser Glu Asn His Arg Leu Arg Met 
785                 790                 795                 800 


Lys Ile Thr Glu Leu Asp Lys Asp Leu Glu Glu Val Thr Met Gln Leu 
                805                 810                 815     


Gln Asp Thr Pro Glu Lys Thr Thr Tyr Ile Lys Gln Asn His Tyr Gln 
            820                 825                 830         


Glu Leu Asn Asp Ile Leu Asn Leu Gly Asn Phe Thr Glu Ser Thr Asp 
        835                 840                 845             


Gly Gly Lys Ala Ile Leu Lys Asn His Leu Asp Gln Asn Pro Gln Leu 
    850                 855                 860                 


Gln Trp Asn Thr Thr Glu Pro Ser Arg Thr Cys Lys Asp Pro Ile Glu 
865                 870                 875                 880 


Asp Ile Asn Ser Pro Glu His Ile Gln Arg Arg Leu Ser Leu Gln Leu 
                885                 890                 895     


Pro Ile Leu His His Ala Tyr Leu Pro Ser Ile Gly Gly Val Asp Ala 
            900                 905                 910         


Ser Cys Val Ser Pro Cys Val Ser Pro Thr Ala Ser Pro Arg His Arg 
        915                 920                 925             


His Val Pro Pro Ser Phe Arg Val Met Val Ser Gly Leu 
    930                 935                 940     


<210>  3289
<211>  740
<212>  PRT
<213>  Homo sapiens

<400>  3289

Met Ala Glu Ser Arg Gly Arg Leu Tyr Leu Trp Met Cys Leu Ala Ala 
1               5                   10                  15      


Ala Leu Ala Ser Phe Leu Met Gly Phe Met Val Gly Trp Phe Ile Lys 
            20                  25                  30          


Pro Leu Lys Glu Thr Thr Thr Ser Val Arg Tyr His Gln Ser Ile Arg 
        35                  40                  45              


Trp Lys Leu Val Ser Glu Met Lys Ala Glu Asn Ile Lys Ser Phe Leu 
    50                  55                  60                  


Arg Ser Phe Thr Lys Leu Pro His Leu Ala Gly Thr Glu Gln Asn Phe 
65                  70                  75                  80  


Leu Leu Ala Lys Lys Ile Gln Thr Gln Trp Lys Lys Phe Gly Leu Asp 
                85                  90                  95      


Ser Ala Lys Leu Val His Tyr Asp Val Leu Leu Ser Tyr Pro Asn Glu 
            100                 105                 110         


Thr Asn Ala Asn Tyr Ile Ser Ile Val Asp Glu His Glu Thr Glu Ile 
        115                 120                 125             


Phe Lys Thr Ser Tyr Leu Glu Pro Pro Pro Asp Gly Tyr Glu Asn Val 
    130                 135                 140                 


Thr Asn Ile Val Pro Pro Tyr Asn Ala Phe Ser Ala Gln Gly Met Pro 
145                 150                 155                 160 


Glu Gly Asp Leu Val Tyr Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe 
                165                 170                 175     


Lys Leu Glu Arg Glu Met Gly Ile Asn Cys Thr Gly Lys Ile Val Ile 
            180                 185                 190         


Ala Arg Tyr Gly Lys Ile Phe Arg Gly Asn Lys Val Lys Asn Ala Met 
        195                 200                 205             


Leu Ala Gly Ala Ile Gly Ile Ile Leu Tyr Ser Asp Pro Ala Asp Tyr 
    210                 215                 220                 


Phe Ala Pro Glu Val Gln Pro Tyr Pro Lys Gly Trp Asn Leu Pro Gly 
225                 230                 235                 240 


Thr Ala Ala Gln Arg Gly Asn Val Leu Asn Leu Asn Gly Ala Gly Asp 
                245                 250                 255     


Pro Leu Thr Pro Gly Tyr Pro Ala Lys Glu Tyr Thr Phe Arg Leu Asp 
            260                 265                 270         


Val Glu Glu Gly Val Gly Ile Pro Arg Ile Pro Val His Pro Ile Gly 
        275                 280                 285             


Tyr Asn Asp Ala Glu Ile Leu Leu Arg Tyr Leu Gly Gly Ile Ala Pro 
    290                 295                 300                 


Pro Asp Lys Ser Trp Lys Gly Ala Leu Asn Val Ser Tyr Ser Ile Gly 
305                 310                 315                 320 


Pro Gly Phe Thr Gly Ser Asp Ser Phe Arg Lys Val Arg Met His Val 
                325                 330                 335     


Tyr Asn Ile Asn Lys Ile Thr Arg Ile Tyr Asn Val Val Gly Thr Ile 
            340                 345                 350         


Arg Gly Ser Val Glu Pro Asp Arg Tyr Val Ile Leu Gly Gly His Arg 
        355                 360                 365             


Asp Ser Trp Val Phe Gly Ala Ile Asp Pro Thr Ser Gly Val Ala Val 
    370                 375                 380                 


Leu Gln Glu Ile Ala Arg Ser Phe Gly Lys Leu Met Ser Lys Gly Trp 
385                 390                 395                 400 


Arg Pro Arg Arg Thr Ile Ile Phe Ala Ser Trp Asp Ala Glu Glu Phe 
                405                 410                 415     


Gly Leu Leu Gly Ser Thr Glu Trp Ala Glu Glu Asn Val Lys Ile Leu 
            420                 425                 430         


Gln Glu Arg Ser Ile Ala Tyr Ile Asn Ser Asp Ser Ser Ile Glu Gly 
        435                 440                 445             


Asn Tyr Thr Leu Arg Val Asp Cys Thr Pro Leu Leu Tyr Gln Leu Val 
    450                 455                 460                 


Tyr Lys Leu Thr Lys Glu Ile Pro Ser Pro Asp Asp Gly Phe Glu Ser 
465                 470                 475                 480 


Lys Ser Leu Tyr Glu Ser Trp Leu Glu Lys Asp Pro Ser Pro Glu Asn 
                485                 490                 495     


Lys Asn Leu Pro Arg Ile Asn Lys Leu Gly Ser Gly Ser Asp Phe Glu 
            500                 505                 510         


Ala Tyr Phe Gln Arg Leu Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr 
        515                 520                 525             


Lys Asn Lys Lys Thr Asp Lys Tyr Ser Ser Tyr Pro Val Tyr His Thr 
    530                 535                 540                 


Ile Tyr Glu Thr Phe Glu Leu Val Glu Lys Phe Tyr Asp Pro Thr Phe 
545                 550                 555                 560 


Lys Lys Gln Leu Ser Val Ala Gln Leu Arg Gly Ala Leu Val Tyr Glu 
                565                 570                 575     


Leu Val Asp Ser Lys Ile Ile Pro Phe Asn Ile Gln Asp Tyr Ala Glu 
            580                 585                 590         


Ala Leu Lys Asn Tyr Ala Ala Ser Ile Tyr Asn Leu Ser Lys Lys His 
        595                 600                 605             


Asp Gln Gln Leu Thr Asp His Gly Val Ser Phe Asp Ser Leu Phe Ser 
    610                 615                 620                 


Ala Val Lys Asn Phe Ser Glu Ala Ala Ser Asp Phe His Lys Arg Leu 
625                 630                 635                 640 


Ile Gln Val Asp Leu Asn Asn Pro Ile Ala Val Arg Met Met Asn Asp 
                645                 650                 655     


Gln Leu Met Leu Leu Glu Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro 
            660                 665                 670         


Gly Lys Leu Phe Tyr Arg His Ile Ile Phe Ala Pro Ser Ser His Asn 
        675                 680                 685             


Lys Tyr Ala Gly Glu Ser Phe Pro Gly Ile Tyr Asp Ala Ile Phe Asp 
    690                 695                 700                 


Ile Glu Asn Lys Ala Asn Ser Arg Leu Ala Trp Lys Glu Val Lys Lys 
705                 710                 715                 720 


His Ile Ser Ile Ala Ala Phe Thr Ile Gln Ala Ala Ala Gly Thr Leu 
                725                 730                 735     


Lys Glu Val Leu 
            740 


<210>  3290
<211>  740
<212>  PRT
<213>  Homo sapiens

<400>  3290

Met Gln Trp Thr Lys Val Leu Gly Leu Gly Leu Gly Ala Ala Ala Leu 
1               5                   10                  15      


Leu Gly Leu Gly Ile Ile Leu Gly His Phe Ala Ile Pro Lys Lys Ala 
            20                  25                  30          


Asn Ser Leu Ala Pro Gln Asp Leu Asp Leu Glu Ile Leu Glu Thr Val 
        35                  40                  45              


Met Gly Gln Leu Asp Ala His Arg Ile Arg Glu Asn Leu Arg Glu Leu 
    50                  55                  60                  


Ser Arg Glu Pro His Leu Ala Ser Ser Pro Arg Asp Glu Asp Leu Val 
65                  70                  75                  80  


Gln Leu Leu Leu Gln Arg Trp Lys Asp Pro Glu Ser Gly Leu Asp Ser 
                85                  90                  95      


Ala Glu Ala Ser Thr Tyr Glu Val Leu Leu Ser Phe Pro Ser Gln Glu 
            100                 105                 110         


Gln Pro Asn Val Val Asp Ile Val Gly Pro Thr Gly Gly Ile Ile His 
        115                 120                 125             


Ser Cys His Arg Thr Glu Glu Asn Val Thr Gly Glu Gln Gly Gly Pro 
    130                 135                 140                 


Asp Val Val Gln Pro Tyr Ala Ala Tyr Ala Pro Ser Gly Thr Pro Gln 
145                 150                 155                 160 


Gly Leu Leu Val Tyr Ala Asn Arg Gly Ala Glu Glu Asp Phe Lys Glu 
                165                 170                 175     


Leu Gln Thr Gln Gly Ile Lys Leu Glu Gly Thr Ile Ala Leu Thr Arg 
            180                 185                 190         


Tyr Gly Gly Val Gly Arg Gly Ala Lys Ala Val Asn Ala Ala Lys His 
        195                 200                 205             


Gly Val Ala Gly Val Leu Val Tyr Thr Asp Pro Ala Asp Ile Asn Asp 
    210                 215                 220                 


Gly Leu Ser Ser Pro Asp Glu Thr Phe Pro Asn Ser Trp Tyr Leu Pro 
225                 230                 235                 240 


Pro Ser Gly Val Glu Arg Gly Ser Tyr Tyr Glu Tyr Phe Gly Asp Pro 
                245                 250                 255     


Leu Thr Pro Tyr Leu Pro Ala Val Pro Ser Ser Phe Arg Val Asp Leu 
            260                 265                 270         


Ala Asn Val Ser Gly Phe Pro Pro Ile Pro Thr Gln Pro Ile Gly Phe 
        275                 280                 285             


Gln Asp Ala Arg Asp Leu Leu Cys Asn Leu Asn Gly Thr Leu Ala Pro 
    290                 295                 300                 


Ala Thr Trp Gln Gly Ala Leu Gly Cys His Tyr Arg Leu Gly Pro Gly 
305                 310                 315                 320 


Phe Arg Pro Asp Gly Asp Phe Pro Ala Asp Ser Gln Val Asn Val Ser 
                325                 330                 335     


Val Tyr Asn Arg Leu Glu Leu Arg Asn Ser Ser Asn Val Leu Gly Ile 
            340                 345                 350         


Ile Arg Gly Ala Val Glu Pro Asp Arg Tyr Val Leu Tyr Gly Asn His 
        355                 360                 365             


Arg Asp Ser Trp Val His Gly Ala Val Asp Pro Ser Ser Gly Thr Ala 
    370                 375                 380                 


Val Leu Leu Glu Leu Ser Arg Val Leu Gly Thr Leu Leu Lys Lys Gly 
385                 390                 395                 400 


Thr Trp Arg Pro Arg Arg Ser Ile Val Phe Ala Ser Trp Gly Ala Glu 
                405                 410                 415     


Glu Phe Gly Leu Ile Gly Ser Thr Glu Phe Thr Glu Glu Phe Phe Asn 
            420                 425                 430         


Lys Leu Gln Glu Arg Thr Val Ala Tyr Ile Asn Val Asp Ile Ser Val 
        435                 440                 445             


Phe Ala Asn Ala Thr Leu Arg Val Gln Gly Thr Pro Pro Val Gln Ser 
    450                 455                 460                 


Val Val Phe Ser Ala Thr Lys Glu Ile Arg Ser Pro Gly Pro Gly Asp 
465                 470                 475                 480 


Leu Ser Ile Tyr Asp Asn Trp Ile Arg Tyr Phe Asn Arg Ser Ser Pro 
                485                 490                 495     


Val Tyr Gly Leu Val Pro Ser Leu Gly Ser Leu Gly Ala Gly Ser Asp 
            500                 505                 510         


Tyr Ala Pro Phe Val His Phe Leu Gly Ile Ser Ser Met Asp Ile Ala 
        515                 520                 525             


Tyr Thr Tyr Asp Arg Ser Lys Thr Ser Ala Arg Ile Tyr Pro Thr Tyr 
    530                 535                 540                 


His Thr Ala Phe Asp Thr Phe Asp Tyr Val Asp Lys Phe Leu Asp Pro 
545                 550                 555                 560 


Gly Phe Ser Ser His Gln Ala Val Ala Arg Thr Ala Gly Ser Val Ile 
                565                 570                 575     


Leu Arg Leu Ser Asp Ser Phe Phe Leu Pro Leu Lys Val Ser Asp Tyr 
            580                 585                 590         


Ser Glu Thr Leu Arg Ser Phe Leu Gln Ala Ala Gln Gln Asp Leu Gly 
        595                 600                 605             


Ala Leu Leu Glu Gln His Ser Ile Ser Leu Gly Pro Leu Val Thr Ala 
    610                 615                 620                 


Val Glu Lys Phe Glu Ala Glu Ala Ala Ala Leu Gly Gln Arg Ile Ser 
625                 630                 635                 640 


Thr Leu Gln Lys Gly Ser Pro Asp Pro Leu Gln Val Arg Met Leu Asn 
                645                 650                 655     


Asp Gln Leu Met Leu Leu Glu Arg Thr Phe Leu Asn Pro Arg Ala Phe 
            660                 665                 670         


Pro Glu Glu Arg Tyr Tyr Ser His Val Leu Trp Ala Pro Arg Thr Gly 
        675                 680                 685             


Ser Val Val Thr Phe Pro Gly Leu Ser Asn Ala Cys Ser Arg Ala Arg 
    690                 695                 700                 


Asp Thr Ala Ser Gly Ser Glu Ala Trp Ala Glu Val Gln Arg Gln Leu 
705                 710                 715                 720 


Ser Ile Val Val Thr Ala Leu Glu Gly Ala Ala Ala Thr Leu Arg Pro 
                725                 730                 735     


Val Ala Asp Leu 
            740 


<210>  3291
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  3291

Met Glu Thr Thr Asn Gly Thr Glu Thr Trp Tyr Glu Ser Leu His Ala 
1               5                   10                  15      


Val Leu Lys Ala Leu Asn Ala Thr Leu His Ser Asn Leu Leu Cys Arg 
            20                  25                  30          


Pro Gly Pro Gly Leu Gly Pro Asp Asn Gln Thr Glu Glu Arg Arg Ala 
        35                  40                  45              


Ser Leu Pro Gly Arg Asp Asp Asn Ser Tyr Met Tyr Ile Leu Phe Val 
    50                  55                  60                  


Met Phe Leu Phe Ala Val Thr Val Gly Ser Leu Ile Leu Gly Tyr Thr 
65                  70                  75                  80  


Arg Ser Arg Lys Val Asp Lys Arg Ser Asp Pro Tyr His Val Tyr Ile 
                85                  90                  95      


Lys Asn Arg Val Ser Met Ile 
            100             


<210>  3292
<211>  1203
<212>  PRT
<213>  Homo sapiens

<400>  3292

Met Asp Lys Leu Pro Pro Ser Met Arg Lys Arg Leu Tyr Ser Leu Pro 
1               5                   10                  15      


Gln Gln Val Gly Ala Lys Ala Trp Ile Met Asp Glu Glu Glu Asp Ala 
            20                  25                  30          


Glu Glu Glu Gly Ala Gly Gly Arg Gln Asp Pro Ser Arg Arg Ser Ile 
        35                  40                  45              


Arg Leu Arg Pro Leu Pro Ser Pro Ser Pro Ser Ala Ala Ala Gly Gly 
    50                  55                  60                  


Thr Glu Ser Arg Ser Ser Ala Leu Gly Ala Ala Asp Ser Glu Gly Pro 
65                  70                  75                  80  


Ala Arg Gly Ala Gly Lys Ser Ser Thr Asn Gly Asp Cys Arg Arg Phe 
                85                  90                  95      


Arg Gly Ser Leu Ala Ser Leu Gly Ser Arg Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Thr Gly Ser Gly Ser Ser His Gly His Leu His Asp Ser Ala Glu Glu 
        115                 120                 125             


Arg Arg Leu Ile Ala Glu Gly Asp Ala Ser Pro Gly Glu Asp Arg Thr 
    130                 135                 140                 


Pro Pro Gly Leu Ala Ala Glu Pro Glu Arg Pro Gly Ala Ser Ala Gln 
145                 150                 155                 160 


Pro Ala Ala Ser Pro Pro Pro Pro Gln Gln Pro Pro Gln Pro Ala Ser 
                165                 170                 175     


Ala Ser Cys Glu Gln Pro Ser Val Asp Thr Ala Ile Lys Val Glu Gly 
            180                 185                 190         


Gly Ala Ala Ala Gly Asp Gln Ile Leu Pro Glu Ala Glu Val Arg Leu 
        195                 200                 205             


Gly Gln Ala Gly Phe Met Gln Arg Gln Phe Gly Ala Met Leu Gln Pro 
    210                 215                 220                 


Gly Val Asn Lys Phe Ser Leu Arg Met Phe Gly Ser Gln Lys Ala Val 
225                 230                 235                 240 


Glu Arg Glu Gln Glu Arg Val Lys Ser Ala Gly Phe Trp Ile Ile His 
                245                 250                 255     


Pro Tyr Ser Asp Phe Arg Phe Tyr Trp Asp Leu Thr Met Leu Leu Leu 
            260                 265                 270         


Met Val Gly Asn Leu Ile Ile Ile Pro Val Gly Ile Thr Phe Phe Lys 
        275                 280                 285             


Asp Glu Asn Thr Thr Pro Trp Ile Val Phe Asn Val Val Ser Asp Thr 
    290                 295                 300                 


Phe Phe Leu Ile Asp Leu Val Leu Asn Phe Arg Thr Gly Ile Val Val 
305                 310                 315                 320 


Glu Asp Asn Thr Glu Ile Ile Leu Asp Pro Gln Arg Ile Lys Met Lys 
                325                 330                 335     


Tyr Leu Lys Ser Trp Phe Met Val Asp Phe Ile Ser Ser Ile Pro Val 
            340                 345                 350         


Asp Tyr Ile Phe Leu Ile Val Glu Thr Arg Ile Asp Ser Glu Val Tyr 
        355                 360                 365             


Lys Thr Ala Arg Ala Leu Arg Ile Val Arg Phe Thr Lys Ile Leu Ser 
    370                 375                 380                 


Leu Leu Arg Leu Leu Arg Leu Ser Arg Leu Ile Arg Tyr Ile His Gln 
385                 390                 395                 400 


Trp Glu Glu Ile Phe His Met Thr Tyr Asp Leu Ala Ser Ala Val Val 
                405                 410                 415     


Arg Ile Val Asn Leu Ile Gly Met Met Leu Leu Leu Cys His Trp Asp 
            420                 425                 430         


Gly Cys Leu Gln Phe Leu Val Pro Met Leu Gln Asp Phe Pro Asp Asp 
        435                 440                 445             


Cys Trp Val Ser Ile Asn Asn Met Val Asn Asn Ser Trp Gly Lys Gln 
    450                 455                 460                 


Tyr Ser Tyr Ala Leu Phe Lys Ala Met Ser His Met Leu Cys Ile Gly 
465                 470                 475                 480 


Tyr Gly Arg Gln Ala Pro Val Gly Met Ser Asp Val Trp Leu Thr Met 
                485                 490                 495     


Leu Ser Met Ile Val Gly Ala Thr Cys Tyr Ala Met Phe Ile Gly His 
            500                 505                 510         


Ala Thr Ala Leu Ile Gln Ser Leu Asp Ser Ser Arg Arg Gln Tyr Gln 
        515                 520                 525             


Glu Lys Tyr Lys Gln Val Glu Gln Tyr Met Ser Phe His Lys Leu Pro 
    530                 535                 540                 


Pro Asp Thr Arg Gln Arg Ile His Asp Tyr Tyr Glu His Arg Tyr Gln 
545                 550                 555                 560 


Gly Lys Met Phe Asp Glu Glu Ser Ile Leu Gly Glu Leu Ser Glu Pro 
                565                 570                 575     


Leu Arg Glu Glu Ile Ile Asn Phe Asn Cys Arg Lys Leu Val Ala Ser 
            580                 585                 590         


Met Pro Leu Phe Ala Asn Ala Asp Pro Asn Phe Val Thr Ser Met Leu 
        595                 600                 605             


Thr Lys Leu Arg Phe Glu Val Phe Gln Pro Gly Asp Tyr Ile Ile Arg 
    610                 615                 620                 


Glu Gly Thr Ile Gly Lys Lys Met Tyr Phe Ile Gln His Gly Val Val 
625                 630                 635                 640 


Ser Val Leu Thr Lys Gly Asn Lys Glu Thr Lys Leu Ala Asp Gly Ser 
                645                 650                 655     


Tyr Phe Gly Glu Ile Cys Leu Leu Thr Arg Gly Arg Arg Thr Ala Ser 
            660                 665                 670         


Val Arg Ala Asp Thr Tyr Cys Arg Leu Tyr Ser Leu Ser Val Asp Asn 
        675                 680                 685             


Phe Asn Glu Val Leu Glu Glu Tyr Pro Met Met Arg Arg Ala Phe Glu 
    690                 695                 700                 


Thr Val Ala Leu Asp Arg Leu Asp Arg Ile Gly Lys Lys Asn Ser Ile 
705                 710                 715                 720 


Leu Leu His Lys Val Gln His Asp Leu Asn Ser Gly Val Phe Asn Tyr 
                725                 730                 735     


Gln Glu Asn Glu Ile Ile Gln Gln Ile Val Gln His Asp Arg Glu Met 
            740                 745                 750         


Ala His Cys Ala His Arg Val Gln Ala Ala Ala Ser Ala Thr Pro Thr 
        755                 760                 765             


Pro Thr Pro Val Ile Trp Thr Pro Leu Ile Gln Ala Pro Leu Gln Ala 
    770                 775                 780                 


Ala Ala Ala Thr Thr Ser Val Ala Ile Ala Leu Thr His His Pro Arg 
785                 790                 795                 800 


Leu Pro Ala Ala Ile Phe Arg Pro Pro Pro Gly Ser Gly Leu Gly Asn 
                805                 810                 815     


Leu Gly Ala Gly Gln Thr Pro Arg His Leu Lys Arg Leu Gln Ser Leu 
            820                 825                 830         


Ile Pro Ser Ala Leu Gly Ser Ala Ser Pro Ala Ser Ser Pro Ser Gln 
        835                 840                 845             


Val Asp Thr Pro Ser Ser Ser Ser Phe His Ile Gln Gln Leu Ala Gly 
    850                 855                 860                 


Phe Ser Ala Pro Ala Gly Leu Ser Pro Leu Leu Pro Ser Ser Ser Ser 
865                 870                 875                 880 


Ser Pro Pro Pro Gly Ala Cys Gly Ser Pro Ser Ala Pro Thr Pro Ser 
                885                 890                 895     


Ala Gly Val Ala Ala Thr Thr Ile Ala Gly Phe Gly His Phe His Lys 
            900                 905                 910         


Ala Leu Gly Gly Ser Leu Ser Ser Ser Asp Ser Pro Leu Leu Thr Pro 
        915                 920                 925             


Leu Gln Pro Gly Ala Arg Ser Pro Gln Ala Ala Gln Pro Ser Pro Ala 
    930                 935                 940                 


Pro Pro Gly Ala Arg Gly Gly Leu Gly Leu Pro Glu His Phe Leu Pro 
945                 950                 955                 960 


Pro Pro Pro Ser Ser Arg Ser Pro Ser Ser Ser Pro Gly Gln Leu Gly 
                965                 970                 975     


Gln Pro Pro Gly Glu Leu Ser Leu Gly Leu Ala Thr Gly Pro Leu Ser 
            980                 985                 990         


Thr Pro Glu Thr Pro Pro Arg Gln  Pro Glu Pro Pro Ser  Leu Val Ala 
        995                 1000                 1005             


Gly Ala  Ser Gly Gly Ala Ser  Pro Val Gly Phe Thr  Pro Arg Gly 
    1010                 1015                 1020             


Gly Leu  Ser Pro Pro Gly His  Ser Pro Gly Pro Pro  Arg Thr Phe 
    1025                 1030                 1035             


Pro Ser  Ala Pro Pro Arg Ala  Ser Gly Ser His Gly  Ser Leu Leu 
    1040                 1045                 1050             


Leu Pro  Pro Ala Ser Ser Pro  Pro Pro Pro Gln Val  Pro Gln Arg 
    1055                 1060                 1065             


Arg Gly  Thr Pro Pro Leu Thr  Pro Gly Arg Leu Thr  Gln Asp Leu 
    1070                 1075                 1080             


Lys Leu  Ile Ser Ala Ser Gln  Pro Ala Leu Pro Gln  Asp Gly Ala 
    1085                 1090                 1095             


Gln Thr  Leu Arg Arg Ala Ser  Pro His Ser Ser Gly  Glu Ser Met 
    1100                 1105                 1110             


Ala Ala  Phe Pro Leu Phe Pro  Arg Ala Gly Gly Gly  Ser Gly Gly 
    1115                 1120                 1125             


Ser Gly  Ser Ser Gly Gly Leu  Gly Pro Pro Gly Arg  Pro Tyr Gly 
    1130                 1135                 1140             


Ala Ile  Pro Gly Gln His Val  Thr Leu Pro Arg Lys  Thr Ser Ser 
    1145                 1150                 1155             


Gly Ser  Leu Pro Pro Pro Leu  Ser Leu Phe Gly Ala  Arg Ala Thr 
    1160                 1165                 1170             


Ser Ser  Gly Gly Pro Pro Leu  Thr Ala Gly Pro Gln  Arg Glu Pro 
    1175                 1180                 1185             


Gly Ala  Arg Pro Glu Pro Val  Arg Ser Lys Leu Pro  Ser Asn Leu 
    1190                 1195                 1200             


<210>  3293
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  3293

Met Ala Val Thr Asp Ser Leu Ser Arg Ala Ala Thr Val Leu Ala Thr 
1               5                   10                  15      


Val Leu Leu Leu Ser Phe Gly Ser Val Ala Ala Ser His Ile Glu Asp 
            20                  25                  30          


Gln Ala Glu Gln Phe Phe Arg Ser Gly His Thr Asn Asn Trp Ala Val 
        35                  40                  45              


Leu Val Cys Thr Ser Arg Phe Trp Phe Asn Tyr Arg His Val Ala Asn 
    50                  55                  60                  


Thr Leu Ser Val Tyr Arg Ser Val Lys Arg Leu Gly Ile Pro Asp Ser 
65                  70                  75                  80  


His Ile Val Leu Met Leu Ala Asp Asp Met Ala Cys Asn Pro Arg Asn 
                85                  90                  95      


Pro Lys Pro Ala Thr Val Phe Ser His Lys Asn Met Glu Leu Asn Val 
            100                 105                 110         


Tyr Gly Asp Asp Val Glu Val Asp Tyr Arg Ser Tyr Glu Val Thr Val 
        115                 120                 125             


Glu Asn Phe Leu Arg Val Leu Thr Gly Arg Ile Pro Pro Ser Thr Pro 
    130                 135                 140                 


Arg Ser Lys Arg Leu Leu Ser Asp Asp Arg Ser Asn Ile Leu Ile Tyr 
145                 150                 155                 160 


Met Thr Gly His Gly Gly Asn Gly Phe Leu Lys Phe Gln Asp Ser Glu 
                165                 170                 175     


Glu Ile Thr Asn Ile Glu Leu Ala Asp Ala Phe Glu Gln Met Trp Gln 
            180                 185                 190         


Lys Arg Arg Tyr Asn Glu Leu Leu Phe Ile Ile Asp Thr Cys Gln Gly 
        195                 200                 205             


Ala Ser Met Tyr Glu Arg Phe Tyr Ser Pro Asn Ile Met Ala Leu Ala 
    210                 215                 220                 


Ser Ser Gln Val Gly Glu Asp Ser Leu Ser His Gln Pro Asp Pro Ala 
225                 230                 235                 240 


Ile Gly Val His Leu Met Asp Arg Tyr Thr Phe Tyr Val Leu Glu Phe 
                245                 250                 255     


Leu Glu Glu Ile Asn Pro Ala Ser Gln Thr Asn Met Asn Asp Leu Phe 
            260                 265                 270         


Gln Val Cys Pro Lys Ser Leu Cys Val Ser Thr Pro Gly His Arg Thr 
        275                 280                 285             


Asp Leu Phe Gln Arg Asp Pro Lys Asn Val Leu Ile Thr Asp Phe Phe 
    290                 295                 300                 


Gly Ser Val Arg Lys Val Glu Ile Thr Thr Glu Thr Ile Lys Leu Gln 
305                 310                 315                 320 


Gln Asp Ser Glu Ile Met Glu Ser Ser Tyr Lys Glu Asp Gln Met Asp 
                325                 330                 335     


Glu Lys Leu Met Glu Pro Leu Lys Tyr Ala Glu Gln Leu Pro Val Ala 
            340                 345                 350         


Gln Ile Ile His Gln Lys Pro Lys Leu Lys Asp Trp His Pro Pro Gly 
        355                 360                 365             


Gly Phe Ile Leu Gly Leu Trp Ala Leu Ile Ile Met Val Phe Phe Lys 
    370                 375                 380                 


Thr Tyr Gly Ile Lys His Met Lys Phe Ile Phe 
385                 390                 395 


<210>  3294
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  3294

Met Ser Thr Gly Pro Asp Val Lys Ala Thr Val Gly Asp Ile Ser Ser 
1               5                   10                  15      


Asp Gly Asn Leu Asn Val Ala Gln Glu Glu Cys Ser Arg Lys Gly Phe 
            20                  25                  30          


Cys Ser Val Arg His Gly Leu Ala Leu Ile Leu Gln Leu Cys Asn Phe 
        35                  40                  45              


Ser Ile Tyr Thr Gln Gln Met Asn Leu Ser Ile Ala Ile Pro Ala Met 
    50                  55                  60                  


Val Asn Asn Thr Ala Pro Pro Ser Gln Pro Asn Ala Ser Thr Glu Arg 
65                  70                  75                  80  


Pro Ser Thr Asp Ser Gln Gly Tyr Trp Asn Glu Thr Leu Lys Glu Phe 
                85                  90                  95      


Lys Ala Met Ala Pro Ala Tyr Asp Trp Ser Pro Glu Ile Gln Gly Ile 
            100                 105                 110         


Ile Leu Ser Ser Leu Asn Tyr Gly Ser Phe Leu Ala Pro Ile Pro Ser 
        115                 120                 125             


Gly Tyr Val Ala Gly Ile Phe Gly Ala Lys Tyr Val Val Gly Ala Gly 
    130                 135                 140                 


Leu Phe Ile Ser Ser Phe Leu Thr Leu Phe Ile Pro Leu Ala Ala Asn 
145                 150                 155                 160 


Ala Gly Val Ala Leu Leu Ile Val Leu Arg Ile Val Gln Gly Ile Ala 
                165                 170                 175     


Gln Val Met Val Leu Thr Gly Gln Tyr Ser Ile Trp Val Lys Trp Ala 
            180                 185                 190         


Pro Pro Leu Glu Arg Ser Gln Leu Thr Thr Ile Ala Gly Ser Gly Ser 
        195                 200                 205             


Met Leu Gly Ser Phe Ile Val Leu Leu Ala Gly Gly Leu Leu Cys Gln 
    210                 215                 220                 


Thr Ile Gly Trp Pro Tyr Val Phe Tyr Ile Phe Gly Gly Ile Gly Cys 
225                 230                 235                 240 


Ala Cys Cys Pro Leu Trp Phe Pro Leu Ile Tyr Asp Asp Pro Val Asn 
                245                 250                 255     


His Pro Phe Ile Ser Ala Gly Glu Lys Arg Tyr Ile Val Cys Ser Leu 
            260                 265                 270         


Ala Gln Gln Asp Cys Ser Pro Gly Trp Ser Leu Pro Ile Arg Ala Met 
        275                 280                 285             


Ile Lys Ser Leu Pro Leu Trp Ala Ile Leu Val Ser Tyr Phe Cys Glu 
    290                 295                 300                 


Tyr Trp Leu Phe Tyr Thr Ile Met Ala Tyr Thr Pro Thr Tyr Ile Ser 
305                 310                 315                 320 


Ser Val Leu Gln Ala Asn Leu Arg Asp Ser Gly Ile Leu Ser Ala Leu 
                325                 330                 335     


Pro Phe Val Val Gly Cys Ile Cys Ile Ile Leu Gly Gly Leu Leu Ala 
            340                 345                 350         


Asp Phe Leu Leu Ser Arg Lys Ile Leu Arg Leu Ile Thr Ile Arg Lys 
        355                 360                 365             


Leu Phe Thr Ala Ile Gly Val Leu Phe Pro Ser Val Ile Leu Val Ser 
    370                 375                 380                 


Leu Pro Trp Val Arg Ser Ser His Ser Met Thr Met Thr Phe Leu Val 
385                 390                 395                 400 


Leu Ser Ser Ala Ile Ser Ser Phe Cys Glu Ser Gly Ala Leu Val Asn 
                405                 410                 415     


Phe Leu Asp Ile Ala Pro Arg Tyr Thr Gly Phe Leu Lys Gly Leu Leu 
            420                 425                 430         


Gln Val Phe Ala His Ile Ala Gly Ala Ile Ser Pro Thr Ala Ala Gly 
        435                 440                 445             


Phe Phe Ile Ser Gln Asp Ser Glu Phe Gly Trp Arg Asn Val Phe Leu 
    450                 455                 460                 


Leu Ser Ala Ala Val Asn Ile Ser Gly Leu Val Phe Tyr Leu Ile Phe 
465                 470                 475                 480 


Gly Arg Ala Asp Val Gln Asp Trp Ala Lys Glu Gln Thr Phe Thr His 
                485                 490                 495     


Leu 
    


<210>  3295
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  3295

Met Ser Trp Ser Phe Leu Thr Arg Leu Leu Glu Glu Ile His Asn His 
1               5                   10                  15      


Ser Thr Phe Val Gly Lys Ile Trp Leu Thr Val Leu Ile Val Phe Arg 
            20                  25                  30          


Ile Val Leu Thr Ala Val Gly Gly Glu Ser Ile Tyr Tyr Asp Glu Gln 
        35                  40                  45              


Ser Lys Phe Val Cys Asn Thr Glu Gln Pro Gly Cys Glu Asn Val Cys 
    50                  55                  60                  


Tyr Asp Ala Phe Ala Pro Leu Ser His Val Arg Phe Trp Val Phe Gln 
65                  70                  75                  80  


Ile Ile Leu Val Ala Thr Pro Ser Val Met Tyr Leu Gly Tyr Ala Ile 
                85                  90                  95      


His Lys Ile Ala Lys Met Glu His Gly Glu Ala Asp Lys Lys Ala Ala 
            100                 105                 110         


Arg Ser Lys Pro Tyr Ala Met Arg Trp Lys Gln His Arg Ala Leu Glu 
        115                 120                 125             


Glu Thr Glu Glu Asp Asn Glu Glu Asp Pro Met Met Tyr Pro Glu Met 
    130                 135                 140                 


Glu Leu Glu Ser Asp Lys Glu Asn Lys Glu Gln Ser Gln Pro Lys Pro 
145                 150                 155                 160 


Lys His Asp Gly Arg Arg Arg Ile Arg Glu Asp Gly Leu Met Lys Ile 
                165                 170                 175     


Tyr Val Leu Gln Leu Leu Ala Arg Thr Val Phe Glu Val Gly Phe Leu 
            180                 185                 190         


Ile Gly Gln Tyr Phe Leu Tyr Gly Phe Gln Val His Pro Phe Tyr Val 
        195                 200                 205             


Cys Ser Arg Leu Pro Cys Pro His Lys Ile Asp Cys Phe Ile Ser Arg 
    210                 215                 220                 


Pro Thr Glu Lys Thr Ile Phe Leu Leu Ile Met Tyr Gly Val Thr Gly 
225                 230                 235                 240 


Leu Cys Leu Leu Leu Asn Ile Trp Glu Met Leu His Leu Gly Phe Gly 
                245                 250                 255     


Thr Ile Arg Asp Ser Leu Asn Ser Lys Arg Arg Glu Leu Glu Asp Pro 
            260                 265                 270         


Gly Ala Tyr Asn Tyr Pro Phe Thr Trp Asn Thr Pro Ser Ala Pro Pro 
        275                 280                 285             


Gly Tyr Asn Ile Ala Val Lys Pro Asp Gln Ile Gln Tyr Thr Glu Leu 
    290                 295                 300                 


Ser Asn Ala Lys Ile Ala Tyr Lys Gln Asn Lys Ala Asn Thr Ala Gln 
305                 310                 315                 320 


Glu Gln Gln Tyr Gly Ser His Glu Glu Asn Leu Pro Ala Asp Leu Glu 
                325                 330                 335     


Ala Leu Gln Arg Glu Ile Arg Met Ala Gln Glu Arg Leu Asp Leu Ala 
            340                 345                 350         


Val Gln Ala Tyr Ser His Gln Asn Asn Pro His Gly Pro Arg Glu Lys 
        355                 360                 365             


Lys Ala Lys Val Gly Ser Lys Ala Gly Ser Asn Lys Ser Thr Ala Ser 
    370                 375                 380                 


Ser Lys Ser Gly Asp Gly Lys Thr Ser Val Trp Ile 
385                 390                 395     


<210>  3296
<211>  640
<212>  PRT
<213>  Homo sapiens

<400>  3296

Met Ala Leu Ser Arg Gly Leu Pro Arg Glu Leu Ala Glu Ala Val Ala 
1               5                   10                  15      


Gly Gly Arg Val Leu Val Val Gly Ala Gly Gly Ile Gly Cys Glu Leu 
            20                  25                  30          


Leu Lys Asn Leu Val Leu Thr Gly Phe Ser His Ile Asp Leu Ile Asp 
        35                  40                  45              


Leu Asp Thr Ile Asp Val Ser Asn Leu Asn Arg Gln Phe Leu Phe Gln 
    50                  55                  60                  


Lys Lys His Val Gly Arg Ser Lys Ala Gln Val Ala Lys Glu Ser Val 
65                  70                  75                  80  


Leu Gln Phe Tyr Pro Lys Ala Asn Ile Val Ala Tyr His Asp Ser Ile 
                85                  90                  95      


Met Asn Pro Asp Tyr Asn Val Glu Phe Phe Arg Gln Phe Ile Leu Val 
            100                 105                 110         


Met Asn Ala Leu Asp Asn Arg Ala Ala Arg Asn His Val Asn Arg Met 
        115                 120                 125             


Cys Leu Ala Ala Asp Val Pro Leu Ile Glu Ser Gly Thr Ala Gly Tyr 
    130                 135                 140                 


Leu Gly Gln Val Thr Thr Ile Lys Lys Gly Val Thr Glu Cys Tyr Glu 
145                 150                 155                 160 


Cys His Pro Lys Pro Thr Gln Arg Thr Phe Pro Gly Cys Thr Ile Arg 
                165                 170                 175     


Asn Thr Pro Ser Glu Pro Ile His Cys Ile Val Trp Ala Lys Tyr Leu 
            180                 185                 190         


Phe Asn Gln Leu Phe Gly Glu Glu Asp Ala Asp Gln Glu Val Ser Pro 
        195                 200                 205             


Asp Arg Ala Asp Pro Glu Ala Ala Trp Glu Pro Thr Glu Ala Glu Ala 
    210                 215                 220                 


Arg Ala Arg Ala Ser Asn Glu Asp Gly Asp Ile Lys Arg Ile Ser Thr 
225                 230                 235                 240 


Lys Glu Trp Ala Lys Ser Thr Gly Tyr Asp Pro Val Lys Leu Phe Thr 
                245                 250                 255     


Lys Leu Phe Lys Asp Asp Ile Arg Tyr Leu Leu Thr Met Asp Lys Leu 
            260                 265                 270         


Trp Arg Lys Arg Lys Pro Pro Val Pro Leu Asp Trp Ala Glu Val Gln 
        275                 280                 285             


Ser Gln Gly Glu Glu Thr Asn Ala Ser Asp Gln Gln Asn Glu Pro Gln 
    290                 295                 300                 


Leu Gly Leu Lys Asp Gln Gln Val Leu Asp Val Lys Ser Tyr Ala Arg 
305                 310                 315                 320 


Leu Phe Ser Lys Ser Ile Glu Thr Leu Arg Val His Leu Ala Glu Lys 
                325                 330                 335     


Gly Asp Gly Ala Glu Leu Ile Trp Asp Lys Asp Asp Pro Ser Ala Met 
            340                 345                 350         


Asp Phe Val Thr Ser Ala Ala Asn Leu Arg Met His Ile Phe Ser Met 
        355                 360                 365             


Asn Met Lys Ser Arg Phe Asp Ile Lys Ser Met Ala Gly Asn Ile Ile 
    370                 375                 380                 


Pro Ala Ile Ala Thr Thr Asn Ala Val Ile Ala Gly Leu Ile Val Leu 
385                 390                 395                 400 


Glu Gly Leu Lys Ile Leu Ser Gly Lys Ile Asp Gln Cys Arg Thr Ile 
                405                 410                 415     


Phe Leu Asn Lys Gln Pro Asn Pro Arg Lys Lys Leu Leu Val Pro Cys 
            420                 425                 430         


Ala Leu Asp Pro Pro Asn Pro Asn Cys Tyr Val Cys Ala Ser Lys Pro 
        435                 440                 445             


Glu Val Thr Val Arg Leu Asn Val His Lys Val Thr Val Leu Thr Leu 
    450                 455                 460                 


Gln Asp Lys Ile Val Lys Glu Lys Phe Ala Met Val Ala Pro Asp Val 
465                 470                 475                 480 


Gln Ile Glu Asp Gly Lys Gly Thr Ile Leu Ile Ser Ser Glu Glu Gly 
                485                 490                 495     


Glu Thr Glu Ala Asn Asn His Lys Lys Leu Ser Glu Phe Gly Ile Arg 
            500                 505                 510         


Asn Gly Ser Arg Leu Gln Ala Asp Asp Phe Leu Gln Asp Tyr Thr Leu 
        515                 520                 525             


Leu Ile Asn Ile Leu His Ser Glu Asp Leu Gly Lys Asp Val Glu Phe 
    530                 535                 540                 


Glu Val Val Gly Asp Ala Pro Glu Lys Val Gly Pro Lys Gln Ala Glu 
545                 550                 555                 560 


Asp Ala Ala Lys Ser Ile Thr Asn Gly Ser Asp Asp Gly Ala Gln Pro 
                565                 570                 575     


Ser Thr Ser Thr Ala Gln Glu Gln Asp Asp Val Leu Ile Val Asp Ser 
            580                 585                 590         


Asp Glu Glu Asp Ser Ser Asn Asn Ala Asp Val Ser Glu Glu Glu Arg 
        595                 600                 605             


Ser Arg Lys Arg Lys Leu Asp Glu Lys Glu Asn Leu Ser Ala Lys Arg 
    610                 615                 620                 


Ser Arg Ile Glu Gln Lys Glu Glu Leu Asp Asp Val Ile Ala Leu Asp 
625                 630                 635                 640 


<210>  3297
<211>  1051
<212>  PRT
<213>  Homo sapiens

<400>  3297

Met Gly Pro Gly Pro Ser Arg Ala Pro Arg Ala Pro Arg Leu Met Leu 
1               5                   10                  15      


Cys Ala Leu Ala Leu Met Val Ala Ala Gly Gly Cys Val Val Ser Ala 
            20                  25                  30          


Phe Asn Leu Asp Thr Arg Phe Leu Val Val Lys Glu Ala Gly Asn Pro 
        35                  40                  45              


Gly Ser Leu Phe Gly Tyr Ser Val Ala Leu His Arg Gln Thr Glu Arg 
    50                  55                  60                  


Gln Gln Arg Tyr Leu Leu Leu Ala Gly Ala Pro Arg Glu Leu Ala Val 
65                  70                  75                  80  


Pro Asp Gly Tyr Thr Asn Arg Thr Gly Ala Val Tyr Leu Cys Pro Leu 
                85                  90                  95      


Thr Ala His Lys Asp Asp Cys Glu Arg Met Asn Ile Thr Val Lys Asn 
            100                 105                 110         


Asp Pro Gly His His Ile Ile Glu Asp Met Trp Leu Gly Val Thr Val 
        115                 120                 125             


Ala Ser Gln Gly Pro Ala Gly Arg Val Leu Val Cys Ala His Arg Tyr 
    130                 135                 140                 


Thr Gln Val Leu Trp Ser Gly Ser Glu Asp Gln Arg Arg Met Val Gly 
145                 150                 155                 160 


Lys Cys Tyr Val Arg Gly Asn Asp Leu Glu Leu Asp Ser Ser Asp Asp 
                165                 170                 175     


Trp Gln Thr Tyr His Asn Glu Met Cys Asn Ser Asn Thr Asp Tyr Leu 
            180                 185                 190         


Glu Thr Gly Met Cys Gln Leu Gly Thr Ser Gly Gly Phe Thr Gln Asn 
        195                 200                 205             


Thr Val Tyr Phe Gly Ala Pro Gly Ala Tyr Asn Trp Lys Gly Asn Ser 
    210                 215                 220                 


Tyr Met Ile Gln Arg Lys Glu Trp Asp Leu Ser Glu Tyr Ser Tyr Lys 
225                 230                 235                 240 


Asp Pro Glu Asp Gln Gly Asn Leu Tyr Ile Gly Tyr Thr Met Gln Val 
                245                 250                 255     


Gly Ser Phe Ile Leu His Pro Lys Asn Ile Thr Ile Val Thr Gly Ala 
            260                 265                 270         


Pro Arg His Arg His Met Gly Ala Val Phe Leu Leu Ser Gln Glu Ala 
        275                 280                 285             


Gly Gly Asp Leu Arg Arg Arg Gln Val Leu Glu Gly Ser Gln Val Gly 
    290                 295                 300                 


Ala Tyr Phe Gly Ser Ala Ile Ala Leu Ala Asp Leu Asn Asn Asp Gly 
305                 310                 315                 320 


Trp Gln Asp Leu Leu Val Gly Ala Pro Tyr Tyr Phe Glu Arg Lys Glu 
                325                 330                 335     


Glu Val Gly Gly Ala Ile Tyr Val Phe Met Asn Gln Ala Gly Thr Ser 
            340                 345                 350         


Phe Pro Ala His Pro Ser Leu Leu Leu His Gly Pro Ser Gly Ser Ala 
        355                 360                 365             


Phe Gly Leu Ser Val Ala Ser Ile Gly Asp Ile Asn Gln Asp Gly Phe 
    370                 375                 380                 


Gln Asp Ile Ala Val Gly Ala Pro Phe Glu Gly Leu Gly Lys Val Tyr 
385                 390                 395                 400 


Ile Tyr His Ser Ser Ser Lys Gly Leu Leu Arg Gln Pro Gln Gln Val 
                405                 410                 415     


Ile His Gly Glu Lys Leu Gly Leu Pro Gly Leu Ala Thr Phe Gly Tyr 
            420                 425                 430         


Ser Leu Ser Gly Gln Met Asp Val Asp Glu Asn Phe Tyr Pro Asp Leu 
        435                 440                 445             


Leu Val Gly Ser Leu Ser Asp His Ile Val Leu Leu Arg Ala Arg Pro 
    450                 455                 460                 


Val Ile Asn Ile Val His Lys Thr Leu Val Pro Arg Pro Ala Val Leu 
465                 470                 475                 480 


Asp Pro Ala Leu Cys Thr Ala Thr Ser Cys Val Gln Val Glu Leu Cys 
                485                 490                 495     


Phe Ala Tyr Asn Gln Ser Ala Gly Asn Pro Asn Tyr Arg Arg Asn Ile 
            500                 505                 510         


Thr Leu Ala Tyr Thr Leu Glu Ala Asp Arg Asp Arg Arg Pro Pro Arg 
        515                 520                 525             


Leu Arg Phe Ala Gly Ser Glu Ser Ala Val Phe His Gly Phe Phe Ser 
    530                 535                 540                 


Met Pro Glu Met Arg Cys Gln Lys Leu Glu Leu Leu Leu Met Asp Asn 
545                 550                 555                 560 


Leu Arg Asp Lys Leu Arg Pro Ile Ile Ile Ser Met Asn Tyr Ser Leu 
                565                 570                 575     


Pro Leu Arg Met Pro Asp Arg Pro Arg Leu Gly Leu Arg Ser Leu Asp 
            580                 585                 590         


Ala Tyr Pro Ile Leu Asn Gln Ala Gln Ala Leu Glu Asn His Thr Glu 
        595                 600                 605             


Val Gln Phe Gln Lys Glu Cys Gly Pro Asp Asn Lys Cys Glu Ser Asn 
    610                 615                 620                 


Leu Gln Met Arg Ala Ala Phe Val Ser Glu Gln Gln Gln Lys Leu Ser 
625                 630                 635                 640 


Arg Leu Gln Tyr Ser Arg Asp Val Arg Lys Leu Leu Leu Ser Ile Asn 
                645                 650                 655     


Val Thr Asn Thr Arg Thr Ser Glu Arg Ser Gly Glu Asp Ala His Glu 
            660                 665                 670         


Ala Leu Leu Thr Leu Val Val Pro Pro Ala Leu Leu Leu Ser Ser Val 
        675                 680                 685             


Arg Pro Pro Gly Ala Cys Gln Ala Asn Glu Thr Ile Phe Cys Glu Leu 
    690                 695                 700                 


Gly Asn Pro Phe Lys Arg Asn Gln Arg Met Glu Leu Leu Ile Ala Phe 
705                 710                 715                 720 


Glu Val Ile Gly Val Thr Leu His Thr Arg Asp Leu Gln Val Gln Leu 
                725                 730                 735     


Gln Leu Ser Thr Ser Ser His Gln Asp Asn Leu Trp Pro Met Ile Leu 
            740                 745                 750         


Thr Leu Leu Val Asp Tyr Thr Leu Gln Thr Ser Leu Ser Met Val Asn 
        755                 760                 765             


His Arg Leu Gln Ser Phe Phe Gly Gly Thr Val Met Gly Glu Ser Gly 
    770                 775                 780                 


Met Lys Thr Val Glu Asp Val Gly Ser Pro Leu Lys Tyr Glu Phe Gln 
785                 790                 795                 800 


Val Gly Pro Met Gly Glu Gly Leu Val Gly Leu Gly Thr Leu Val Leu 
                805                 810                 815     


Gly Leu Glu Trp Pro Tyr Glu Val Ser Asn Gly Lys Trp Leu Leu Tyr 
            820                 825                 830         


Pro Thr Glu Ile Thr Val His Gly Asn Gly Ser Trp Pro Cys Arg Pro 
        835                 840                 845             


Pro Gly Asp Leu Ile Asn Pro Leu Asn Leu Thr Leu Ser Asp Pro Gly 
    850                 855                 860                 


Asp Arg Pro Ser Ser Pro Gln Arg Arg Arg Arg Gln Leu Asp Pro Gly 
865                 870                 875                 880 


Gly Gly Gln Gly Pro Pro Pro Val Thr Leu Ala Ala Ala Lys Lys Ala 
                885                 890                 895     


Lys Ser Glu Thr Val Leu Thr Cys Ala Thr Gly Arg Ala His Cys Val 
            900                 905                 910         


Trp Leu Glu Cys Pro Ile Pro Asp Ala Pro Val Val Thr Asn Val Thr 
        915                 920                 925             


Val Lys Ala Arg Val Trp Asn Ser Thr Phe Ile Glu Asp Tyr Arg Asp 
    930                 935                 940                 


Phe Asp Arg Val Arg Val Asn Gly Trp Ala Thr Leu Phe Leu Arg Thr 
945                 950                 955                 960 


Ser Ile Pro Thr Ile Asn Met Glu Asn Lys Thr Thr Trp Phe Ser Val 
                965                 970                 975     


Asp Ile Asp Ser Glu Leu Val Glu Glu Leu Pro Ala Glu Ile Glu Leu 
            980                 985                 990         


Trp Leu Val Leu Val Ala Val Gly  Ala Gly Leu Leu Leu  Leu Gly Leu 
        995                 1000                 1005             


Ile Ile  Leu Leu Leu Trp Lys  Cys Gly Phe Phe Lys  Arg Ala Arg 
    1010                 1015                 1020             


Thr Arg  Ala Leu Tyr Glu Ala  Lys Arg Gln Lys Ala  Glu Met Lys 
    1025                 1030                 1035             


Ser Gln  Pro Ser Glu Thr Glu  Arg Leu Thr Asp Asp  Tyr 
    1040                 1045                 1050     


<210>  3298
<211>  2261
<212>  PRT
<213>  Homo sapiens

<400>  3298

Met Ala Cys Trp Pro Gln Leu Arg Leu Leu Leu Trp Lys Asn Leu Thr 
1               5                   10                  15      


Phe Arg Arg Arg Gln Thr Cys Gln Leu Leu Leu Glu Val Ala Trp Pro 
            20                  25                  30          


Leu Phe Ile Phe Leu Ile Leu Ile Ser Val Arg Leu Ser Tyr Pro Pro 
        35                  40                  45              


Tyr Glu Gln His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  


Gly Thr Leu Pro Trp Val Gln Gly Ile Ile Cys Asn Ala Asn Asn Pro 
65                  70                  75                  80  


Cys Phe Arg Tyr Pro Thr Pro Gly Glu Ala Pro Gly Val Val Gly Asn 
                85                  90                  95      


Phe Asn Lys Ser Ile Val Ala Arg Leu Phe Ser Asp Ala Arg Arg Leu 
            100                 105                 110         


Leu Leu Tyr Ser Gln Lys Asp Thr Ser Met Lys Asp Met Arg Lys Val 
        115                 120                 125             


Leu Arg Thr Leu Gln Gln Ile Lys Lys Ser Ser Ser Asn Leu Lys Leu 
    130                 135                 140                 


Gln Asp Phe Leu Val Asp Asn Glu Thr Phe Ser Gly Phe Leu Tyr His 
145                 150                 155                 160 


Asn Leu Ser Leu Pro Lys Ser Thr Val Asp Lys Met Leu Arg Ala Asp 
                165                 170                 175     


Val Ile Leu His Lys Val Phe Leu Gln Gly Tyr Gln Leu His Leu Thr 
            180                 185                 190         


Ser Leu Cys Asn Gly Ser Lys Ser Glu Glu Met Ile Gln Leu Gly Asp 
        195                 200                 205             


Gln Glu Val Ser Glu Leu Cys Gly Leu Pro Arg Glu Lys Leu Ala Ala 
    210                 215                 220                 


Ala Glu Arg Val Leu Arg Ser Asn Met Asp Ile Leu Lys Pro Ile Leu 
225                 230                 235                 240 


Arg Thr Leu Asn Ser Thr Ser Pro Phe Pro Ser Lys Glu Leu Ala Glu 
                245                 250                 255     


Ala Thr Lys Thr Leu Leu His Ser Leu Gly Thr Leu Ala Gln Glu Leu 
            260                 265                 270         


Phe Ser Met Arg Ser Trp Ser Asp Met Arg Gln Glu Val Met Phe Leu 
        275                 280                 285             


Thr Asn Val Asn Ser Ser Ser Ser Ser Thr Gln Ile Tyr Gln Ala Val 
    290                 295                 300                 


Ser Arg Ile Val Cys Gly His Pro Glu Gly Gly Gly Leu Lys Ile Lys 
305                 310                 315                 320 


Ser Leu Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Leu Phe Gly Gly 
                325                 330                 335     


Asn Gly Thr Glu Glu Asp Ala Glu Thr Phe Tyr Asp Asn Ser Thr Thr 
            340                 345                 350         


Pro Tyr Cys Asn Asp Leu Met Lys Asn Leu Glu Ser Ser Pro Leu Ser 
        355                 360                 365             


Arg Ile Ile Trp Lys Ala Leu Lys Pro Leu Leu Val Gly Lys Ile Leu 
    370                 375                 380                 


Tyr Thr Pro Asp Thr Pro Ala Thr Arg Gln Val Met Ala Glu Val Asn 
385                 390                 395                 400 


Lys Thr Phe Gln Glu Leu Ala Val Phe His Asp Leu Glu Gly Met Trp 
                405                 410                 415     


Glu Glu Leu Ser Pro Lys Ile Trp Thr Phe Met Glu Asn Ser Gln Glu 
            420                 425                 430         


Met Asp Leu Val Arg Met Leu Leu Asp Ser Arg Asp Asn Asp His Phe 
        435                 440                 445             


Trp Glu Gln Gln Leu Asp Gly Leu Asp Trp Thr Ala Gln Asp Ile Val 
    450                 455                 460                 


Ala Phe Leu Ala Lys His Pro Glu Asp Val Gln Ser Ser Asn Gly Ser 
465                 470                 475                 480 


Val Tyr Thr Trp Arg Glu Ala Phe Asn Glu Thr Asn Gln Ala Ile Arg 
                485                 490                 495     


Thr Ile Ser Arg Phe Met Glu Cys Val Asn Leu Asn Lys Leu Glu Pro 
            500                 505                 510         


Ile Ala Thr Glu Val Trp Leu Ile Asn Lys Ser Met Glu Leu Leu Asp 
        515                 520                 525             


Glu Arg Lys Phe Trp Ala Gly Ile Val Phe Thr Gly Ile Thr Pro Gly 
    530                 535                 540                 


Ser Ile Glu Leu Pro His His Val Lys Tyr Lys Ile Arg Met Asp Ile 
545                 550                 555                 560 


Asp Asn Val Glu Arg Thr Asn Lys Ile Lys Asp Gly Tyr Trp Asp Pro 
                565                 570                 575     


Gly Pro Arg Ala Asp Pro Phe Glu Asp Met Arg Tyr Val Trp Gly Gly 
            580                 585                 590         


Phe Ala Tyr Leu Gln Asp Val Val Glu Gln Ala Ile Ile Arg Val Leu 
        595                 600                 605             


Thr Gly Thr Glu Lys Lys Thr Gly Val Tyr Met Gln Gln Met Pro Tyr 
    610                 615                 620                 


Pro Cys Tyr Val Asp Asp Ile Phe Leu Arg Val Met Ser Arg Ser Met 
625                 630                 635                 640 


Pro Leu Phe Met Thr Leu Ala Trp Ile Tyr Ser Val Ala Val Ile Ile 
                645                 650                 655     


Lys Gly Ile Val Tyr Glu Lys Glu Ala Arg Leu Lys Glu Thr Met Arg 
            660                 665                 670         


Ile Met Gly Leu Asp Asn Ser Ile Leu Trp Phe Ser Trp Phe Ile Ser 
        675                 680                 685             


Ser Leu Ile Pro Leu Leu Val Ser Ala Gly Leu Leu Val Val Ile Leu 
    690                 695                 700                 


Lys Leu Gly Asn Leu Leu Pro Tyr Ser Asp Pro Ser Val Val Phe Val 
705                 710                 715                 720 


Phe Leu Ser Val Phe Ala Val Val Thr Ile Leu Gln Cys Phe Leu Ile 
                725                 730                 735     


Ser Thr Leu Phe Ser Arg Ala Asn Leu Ala Ala Ala Cys Gly Gly Ile 
            740                 745                 750         


Ile Tyr Phe Thr Leu Tyr Leu Pro Tyr Val Leu Cys Val Ala Trp Gln 
        755                 760                 765             


Asp Tyr Val Gly Phe Thr Leu Lys Ile Phe Ala Ser Leu Leu Ser Pro 
    770                 775                 780                 


Val Ala Phe Gly Phe Gly Cys Glu Tyr Phe Ala Leu Phe Glu Glu Gln 
785                 790                 795                 800 


Gly Ile Gly Val Gln Trp Asp Asn Leu Phe Glu Ser Pro Val Glu Glu 
                805                 810                 815     


Asp Gly Phe Asn Leu Thr Thr Ser Val Ser Met Met Leu Phe Asp Thr 
            820                 825                 830         


Phe Leu Tyr Gly Val Met Thr Trp Tyr Ile Glu Ala Val Phe Pro Gly 
        835                 840                 845             


Gln Tyr Gly Ile Pro Arg Pro Trp Tyr Phe Pro Cys Thr Lys Ser Tyr 
    850                 855                 860                 


Trp Phe Gly Glu Glu Ser Asp Glu Lys Ser His Pro Gly Ser Asn Gln 
865                 870                 875                 880 


Lys Arg Ile Ser Glu Ile Cys Met Glu Glu Glu Pro Thr His Leu Lys 
                885                 890                 895     


Leu Gly Val Ser Ile Gln Asn Leu Val Lys Val Tyr Arg Asp Gly Met 
            900                 905                 910         


Lys Val Ala Val Asp Gly Leu Ala Leu Asn Phe Tyr Glu Gly Gln Ile 
        915                 920                 925             


Thr Ser Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Met Ser 
    930                 935                 940                 


Ile Leu Thr Gly Leu Phe Pro Pro Thr Ser Gly Thr Ala Tyr Ile Leu 
945                 950                 955                 960 


Gly Lys Asp Ile Arg Ser Glu Met Ser Thr Ile Arg Gln Asn Leu Gly 
                965                 970                 975     


Val Cys Pro Gln His Asn Val Leu Phe Asp Met Leu Thr Val Glu Glu 
            980                 985                 990         


His Ile Trp Phe Tyr Ala Arg Leu  Lys Gly Leu Ser Glu  Lys His Val 
        995                 1000                 1005             


Lys Ala  Glu Met Glu Gln Met  Ala Leu Asp Val Gly  Leu Pro Ser 
    1010                 1015                 1020             


Ser Lys  Leu Lys Ser Lys Thr  Ser Gln Leu Ser Gly  Gly Met Gln 
    1025                 1030                 1035             


Arg Lys  Leu Ser Val Ala Leu  Ala Phe Val Gly Gly  Ser Lys Val 
    1040                 1045                 1050             


Val Ile  Leu Asp Glu Pro Thr  Ala Gly Val Asp Pro  Tyr Ser Arg 
    1055                 1060                 1065             


Arg Gly  Ile Trp Glu Leu Leu  Leu Lys Tyr Arg Gln  Gly Arg Thr 
    1070                 1075                 1080             


Ile Ile  Leu Ser Thr His His  Met Asp Glu Ala Asp  Val Leu Gly 
    1085                 1090                 1095             


Asp Arg  Ile Ala Ile Ile Ser  His Gly Lys Leu Cys  Cys Val Gly 
    1100                 1105                 1110             


Ser Ser  Leu Phe Leu Lys Asn  Gln Leu Gly Thr Gly  Tyr Tyr Leu 
    1115                 1120                 1125             


Thr Leu  Val Lys Lys Asp Val  Glu Ser Ser Leu Ser  Ser Cys Arg 
    1130                 1135                 1140             


Asn Ser  Ser Ser Thr Val Ser  Tyr Leu Lys Lys Glu  Asp Ser Val 
    1145                 1150                 1155             


Ser Gln  Ser Ser Ser Asp Ala  Gly Leu Gly Ser Asp  His Glu Ser 
    1160                 1165                 1170             


Asp Thr  Leu Thr Ile Asp Val  Ser Ala Ile Ser Asn  Leu Ile Arg 
    1175                 1180                 1185             


Lys His  Val Ser Glu Ala Arg  Leu Val Glu Asp Ile  Gly His Glu 
    1190                 1195                 1200             


Leu Thr  Tyr Val Leu Pro Tyr  Glu Ala Ala Lys Glu  Gly Ala Phe 
    1205                 1210                 1215             


Val Glu  Leu Phe His Glu Ile  Asp Asp Arg Leu Ser  Asp Leu Gly 
    1220                 1225                 1230             


Ile Ser  Ser Tyr Gly Ile Ser  Glu Thr Thr Leu Glu  Glu Ile Phe 
    1235                 1240                 1245             


Leu Lys  Val Ala Glu Glu Ser  Gly Val Asp Ala Glu  Thr Ser Asp 
    1250                 1255                 1260             


Gly Thr  Leu Pro Ala Arg Arg  Asn Arg Arg Ala Phe  Gly Asp Lys 
    1265                 1270                 1275             


Gln Ser  Cys Leu Arg Pro Phe  Thr Glu Asp Asp Ala  Ala Asp Pro 
    1280                 1285                 1290             


Asn Asp  Ser Asp Ile Asp Pro  Glu Ser Arg Glu Thr  Asp Leu Leu 
    1295                 1300                 1305             


Ser Gly  Met Asp Gly Lys Gly  Ser Tyr Gln Val Lys  Gly Trp Lys 
    1310                 1315                 1320             


Leu Thr  Gln Gln Gln Phe Val  Ala Leu Leu Trp Lys  Arg Leu Leu 
    1325                 1330                 1335             


Ile Ala  Arg Arg Ser Arg Lys  Gly Phe Phe Ala Gln  Ile Val Leu 
    1340                 1345                 1350             


Pro Ala  Val Phe Val Cys Ile  Ala Leu Val Phe Ser  Leu Ile Val 
    1355                 1360                 1365             


Pro Pro  Phe Gly Lys Tyr Pro  Ser Leu Glu Leu Gln  Pro Trp Met 
    1370                 1375                 1380             


Tyr Asn  Glu Gln Tyr Thr Phe  Val Ser Asn Asp Ala  Pro Glu Asp 
    1385                 1390                 1395             


Thr Gly  Thr Leu Glu Leu Leu  Asn Ala Leu Thr Lys  Asp Pro Gly 
    1400                 1405                 1410             


Phe Gly  Thr Arg Cys Met Glu  Gly Asn Pro Ile Pro  Asp Thr Pro 
    1415                 1420                 1425             


Cys Gln  Ala Gly Glu Glu Glu  Trp Thr Thr Ala Pro  Val Pro Gln 
    1430                 1435                 1440             


Thr Ile  Met Asp Leu Phe Gln  Asn Gly Asn Trp Thr  Met Gln Asn 
    1445                 1450                 1455             


Pro Ser  Pro Ala Cys Gln Cys  Ser Ser Asp Lys Ile  Lys Lys Met 
    1460                 1465                 1470             


Leu Pro  Val Cys Pro Pro Gly  Ala Gly Gly Leu Pro  Pro Pro Gln 
    1475                 1480                 1485             


Arg Lys  Gln Asn Thr Ala Asp  Ile Leu Gln Asp Leu  Thr Gly Arg 
    1490                 1495                 1500             


Asn Ile  Ser Asp Tyr Leu Val  Lys Thr Tyr Val Gln  Ile Ile Ala 
    1505                 1510                 1515             


Lys Ser  Leu Lys Asn Lys Ile  Trp Val Asn Glu Phe  Arg Tyr Gly 
    1520                 1525                 1530             


Gly Phe  Ser Leu Gly Val Ser  Asn Thr Gln Ala Leu  Pro Pro Ser 
    1535                 1540                 1545             


Gln Glu  Val Asn Asp Ala Ile  Lys Gln Met Lys Lys  His Leu Lys 
    1550                 1555                 1560             


Leu Ala  Lys Asp Ser Ser Ala  Asp Arg Phe Leu Asn  Ser Leu Gly 
    1565                 1570                 1575             


Arg Phe  Met Thr Gly Leu Asp  Thr Lys Asn Asn Val  Lys Val Trp 
    1580                 1585                 1590             


Phe Asn  Asn Lys Gly Trp His  Ala Ile Ser Ser Phe  Leu Asn Val 
    1595                 1600                 1605             


Ile Asn  Asn Ala Ile Leu Arg  Ala Asn Leu Gln Lys  Gly Glu Asn 
    1610                 1615                 1620             


Pro Ser  His Tyr Gly Ile Thr  Ala Phe Asn His Pro  Leu Asn Leu 
    1625                 1630                 1635             


Thr Lys  Gln Gln Leu Ser Glu  Val Ala Leu Met Thr  Thr Ser Val 
    1640                 1645                 1650             


Asp Val  Leu Val Ser Ile Cys  Val Ile Phe Ala Met  Ser Phe Val 
    1655                 1660                 1665             


Pro Ala  Ser Phe Val Val Phe  Leu Ile Gln Glu Arg  Val Ser Lys 
    1670                 1675                 1680             


Ala Lys  His Leu Gln Phe Ile  Ser Gly Val Lys Pro  Val Ile Tyr 
    1685                 1690                 1695             


Trp Leu  Ser Asn Phe Val Trp  Asp Met Cys Asn Tyr  Val Val Pro 
    1700                 1705                 1710             


Ala Thr  Leu Val Ile Ile Ile  Phe Ile Cys Phe Gln  Gln Lys Ser 
    1715                 1720                 1725             


Tyr Val  Ser Ser Thr Asn Leu  Pro Val Leu Ala Leu  Leu Leu Leu 
    1730                 1735                 1740             


Leu Tyr  Gly Trp Ser Ile Thr  Pro Leu Met Tyr Pro  Ala Ser Phe 
    1745                 1750                 1755             


Val Phe  Lys Ile Pro Ser Thr  Ala Tyr Val Val Leu  Thr Ser Val 
    1760                 1765                 1770             


Asn Leu  Phe Ile Gly Ile Asn  Gly Ser Val Ala Thr  Phe Val Leu 
    1775                 1780                 1785             


Glu Leu  Phe Thr Asp Asn Lys  Leu Asn Asn Ile Asn  Asp Ile Leu 
    1790                 1795                 1800             


Lys Ser  Val Phe Leu Ile Phe  Pro His Phe Cys Leu  Gly Arg Gly 
    1805                 1810                 1815             


Leu Ile  Asp Met Val Lys Asn  Gln Ala Met Ala Asp  Ala Leu Glu 
    1820                 1825                 1830             


Arg Phe  Gly Glu Asn Arg Phe  Val Ser Pro Leu Ser  Trp Asp Leu 
    1835                 1840                 1845             


Val Gly  Arg Asn Leu Phe Ala  Met Ala Val Glu Gly  Val Val Phe 
    1850                 1855                 1860             


Phe Leu  Ile Thr Val Leu Ile  Gln Tyr Arg Phe Phe  Ile Arg Pro 
    1865                 1870                 1875             


Arg Pro  Val Asn Ala Lys Leu  Ser Pro Leu Asn Asp  Glu Asp Glu 
    1880                 1885                 1890             


Asp Val  Arg Arg Glu Arg Gln  Arg Ile Leu Asp Gly  Gly Gly Gln 
    1895                 1900                 1905             


Asn Asp  Ile Leu Glu Ile Lys  Glu Leu Thr Lys Ile  Tyr Arg Arg 
    1910                 1915                 1920             


Lys Arg  Lys Pro Ala Val Asp  Arg Ile Cys Val Gly  Ile Pro Pro 
    1925                 1930                 1935             


Gly Glu  Cys Phe Gly Leu Leu  Gly Val Asn Gly Ala  Gly Lys Ser 
    1940                 1945                 1950             


Ser Thr  Phe Lys Met Leu Thr  Gly Asp Thr Thr Val  Thr Arg Gly 
    1955                 1960                 1965             


Asp Ala  Phe Leu Asn Lys Asn  Ser Ile Leu Ser Asn  Ile His Glu 
    1970                 1975                 1980             


Val His  Gln Asn Met Gly Tyr  Cys Pro Gln Phe Asp  Ala Ile Thr 
    1985                 1990                 1995             


Glu Leu  Leu Thr Gly Arg Glu  His Val Glu Phe Phe  Ala Leu Leu 
    2000                 2005                 2010             


Arg Gly  Val Pro Glu Lys Glu  Val Gly Lys Val Gly  Glu Trp Ala 
    2015                 2020                 2025             


Ile Arg  Lys Leu Gly Leu Val  Lys Tyr Gly Glu Lys  Tyr Ala Gly 
    2030                 2035                 2040             


Asn Tyr  Ser Gly Gly Asn Lys  Arg Lys Leu Ser Thr  Ala Met Ala 
    2045                 2050                 2055             


Leu Ile  Gly Gly Pro Pro Val  Val Phe Leu Asp Glu  Pro Thr Thr 
    2060                 2065                 2070             


Gly Met  Asp Pro Lys Ala Arg  Arg Phe Leu Trp Asn  Cys Ala Leu 
    2075                 2080                 2085             


Ser Val  Val Lys Glu Gly Arg  Ser Val Val Leu Thr  Ser His Ser 
    2090                 2095                 2100             


Met Glu  Glu Cys Glu Ala Leu  Cys Thr Arg Met Ala  Ile Met Val 
    2105                 2110                 2115             


Asn Gly  Arg Phe Arg Cys Leu  Gly Ser Val Gln His  Leu Lys Asn 
    2120                 2125                 2130             


Arg Phe  Gly Asp Gly Tyr Thr  Ile Val Val Arg Ile  Ala Gly Ser 
    2135                 2140                 2145             


Asn Pro  Asp Leu Lys Pro Val  Gln Asp Phe Phe Gly  Leu Ala Phe 
    2150                 2155                 2160             


Pro Gly  Ser Val Leu Lys Glu  Lys His Arg Asn Met  Leu Gln Tyr 
    2165                 2170                 2175             


Gln Leu  Pro Ser Ser Leu Ser  Ser Leu Ala Arg Ile  Phe Ser Ile 
    2180                 2185                 2190             


Leu Ser  Gln Ser Lys Lys Arg  Leu His Ile Glu Asp  Tyr Ser Val 
    2195                 2200                 2205             


Ser Gln  Thr Thr Leu Asp Gln  Val Phe Val Asn Phe  Ala Lys Asp 
    2210                 2215                 2220             


Gln Ser  Asp Asp Asp His Leu  Lys Asp Leu Ser Leu  His Lys Asn 
    2225                 2230                 2235             


Gln Thr  Val Val Asp Val Ala  Val Leu Thr Ser Phe  Leu Gln Asp 
    2240                 2245                 2250             


Glu Lys  Val Lys Glu Ser Tyr  Val 
    2255                 2260     


<210>  3299
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  3299

Met Gly Cys Ser Ala Lys Ala Arg Trp Ala Ala Gly Ala Leu Gly Val 
1               5                   10                  15      


Ala Gly Leu Leu Cys Ala Val Leu Gly Ala Val Met Ile Val Met Val 
            20                  25                  30          


Pro Ser Leu Ile Lys Gln Gln Val Leu Lys Asn Val Arg Ile Asp Pro 
        35                  40                  45              


Ser Ser Leu Ser Phe Asn Met Trp Lys Glu Ile Pro Ile Pro Phe Tyr 
    50                  55                  60                  


Leu Ser Val Tyr Phe Phe Asp Val Met Asn Pro Ser Glu Ile Leu Lys 
65                  70                  75                  80  


Gly Glu Lys Pro Gln Val Arg Glu Arg Gly Pro Tyr Val Tyr Arg Glu 
                85                  90                  95      


Phe Arg His Lys Ser Asn Ile Thr Phe Asn Asn Asn Asp Thr Val Ser 
            100                 105                 110         


Phe Leu Glu Tyr Arg Thr Phe Gln Phe Gln Pro Ser Lys Ser His Gly 
        115                 120                 125             


Ser Glu Ser Asp Tyr Ile Val Met Pro Asn Ile Leu Val Leu Gly Ala 
    130                 135                 140                 


Ala Val Met Met Glu Asn Lys Pro Met Thr Leu Lys Leu Ile Met Thr 
145                 150                 155                 160 


Leu Ala Phe Thr Thr Leu Gly Glu Arg Ala Phe Met Asn Arg Thr Val 
                165                 170                 175     


Gly Glu Ile Met Trp Gly Tyr Lys Asp Pro Leu Val Asn Leu Ile Asn 
            180                 185                 190         


Lys Tyr Phe Pro Gly Met Phe Pro Phe Lys Asp Lys Phe Gly Leu Phe 
        195                 200                 205             


Ala Glu Leu Asn Asn Ser Asp Ser Gly Leu Phe Thr Val Phe Thr Gly 
    210                 215                 220                 


Val Gln Asn Ile Ser Arg Ile His Leu Val Asp Lys Trp Asn Gly Leu 
225                 230                 235                 240 


Ser Lys Val Asp Phe Trp His Ser Asp Gln Cys Asn Met Ile Asn Gly 
                245                 250                 255     


Thr Ser Gly Gln Met Trp Pro Pro Phe Met Thr Pro Glu Ser Ser Leu 
            260                 265                 270         


Glu Phe Tyr Ser Pro Glu Ala Cys Arg Ser Met Lys Leu Met Tyr Lys 
        275                 280                 285             


Glu Ser Gly Val Phe Glu Gly Ile Pro Thr Tyr Arg Phe Val Ala Pro 
    290                 295                 300                 


Lys Thr Leu Phe Ala Asn Gly Ser Ile Tyr Pro Pro Asn Glu Gly Phe 
305                 310                 315                 320 


Cys Pro Cys Leu Glu Ser Gly Ile Gln Asn Val Ser Thr Cys Arg Phe 
                325                 330                 335     


Ser Ala Pro Leu Phe Leu Ser His Pro His Phe Leu Asn Ala Asp Pro 
            340                 345                 350         


Val Leu Ala Glu Ala Val Thr Gly Leu His Pro Asn Gln Glu Ala His 
        355                 360                 365             


Ser Leu Phe Leu Asp Ile His Pro Val Thr Gly Ile Pro Met Asn Cys 
    370                 375                 380                 


Ser Val Lys Leu Gln Leu Ser Leu Tyr Met Lys Ser Val Ala Gly Ile 
385                 390                 395                 400 


Gly Gln Thr Gly Lys Ile Glu Pro Val Val Leu Pro Leu Leu Trp Phe 
                405                 410                 415     


Ala Glu Ser Gly Ala Met Glu Gly Glu Thr Leu His Thr Phe Tyr Thr 
            420                 425                 430         


Gln Leu Val Leu Met Pro Lys Val Met His Tyr Ala Gln Tyr Val Leu 
        435                 440                 445             


Leu Ala Leu Gly Cys Val Leu Leu Leu Val Pro Val Ile Cys Gln Ile 
    450                 455                 460                 


Arg Ser Gln Glu Lys Cys Tyr Leu Phe Trp Ser Ser Ser Lys Lys Gly 
465                 470                 475                 480 


Ser Lys Asp Lys Glu Ala Ile Gln Ala Tyr Ser Glu Ser Leu Met Thr 
                485                 490                 495     


Ser Ala Pro Lys Gly Ser Val Leu Gln Glu Ala Lys Leu 
            500                 505                 


<210>  3300
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  3300

Met Gly Arg Cys Cys Phe Tyr Thr Ala Gly Thr Leu Ser Leu Leu Leu 
1               5                   10                  15      


Leu Val Thr Ser Val Thr Leu Leu Val Ala Arg Val Phe Gln Lys Ala 
            20                  25                  30          


Val Asp Gln Ser Ile Glu Lys Lys Ile Val Leu Arg Asn Gly Thr Glu 
        35                  40                  45              


Ala Phe Asp Ser Trp Glu Lys Pro Pro Leu Pro Val Tyr Thr Gln Phe 
    50                  55                  60                  


Tyr Phe Phe Asn Val Thr Asn Pro Glu Glu Ile Leu Arg Gly Glu Thr 
65                  70                  75                  80  


Pro Arg Val Glu Glu Val Gly Pro Tyr Thr Tyr Arg Glu Leu Arg Asn 
                85                  90                  95      


Lys Ala Asn Ile Gln Phe Gly Asp Asn Gly Thr Thr Ile Ser Ala Val 
            100                 105                 110         


Ser Asn Lys Ala Tyr Val Phe Glu Arg Asp Gln Ser Val Gly Asp Pro 
        115                 120                 125             


Lys Ile Asp Leu Ile Arg Thr Leu Asn Ile Pro Val Leu Thr Val Ile 
    130                 135                 140                 


Glu Trp Ser Gln Val His Phe Leu Arg Glu Ile Ile Glu Ala Met Leu 
145                 150                 155                 160 


Lys Ala Tyr Gln Gln Lys Leu Phe Val Thr His Thr Val Asp Glu Leu 
                165                 170                 175     


Leu Trp Gly Tyr Lys Asp Glu Ile Leu Ser Leu Ile His Val Phe Arg 
            180                 185                 190         


Pro Asp Ile Ser Pro Tyr Phe Gly Leu Phe Tyr Glu Lys Asn Gly Thr 
        195                 200                 205             


Asn Asp Gly Asp Tyr Val Phe Leu Thr Gly Glu Asp Ser Tyr Leu Asn 
    210                 215                 220                 


Phe Thr Lys Ile Val Glu Trp Asn Gly Lys Thr Ser Leu Asp Trp Trp 
225                 230                 235                 240 


Ile Thr Asp Lys Cys Asn Met Ile Asn Gly Thr Asp Gly Asp Ser Phe 
                245                 250                 255     


His Pro Leu Ile Thr Lys Asp Glu Val Leu Tyr Val Phe Pro Ser Asp 
            260                 265                 270         


Phe Cys Arg Ser Val Tyr Ile Thr Phe Ser Asp Tyr Glu Ser Val Gln 
        275                 280                 285             


Gly Leu Pro Ala Phe Arg Tyr Lys Val Pro Ala Glu Ile Leu Ala Asn 
    290                 295                 300                 


Thr Ser Asp Asn Ala Gly Phe Cys Ile Pro Glu Gly Asn Cys Leu Gly 
305                 310                 315                 320 


Ser Gly Val Leu Asn Val Ser Ile Cys Lys Asn Gly Ala Pro Ile Ile 
                325                 330                 335     


Met Ser Phe Pro His Phe Tyr Gln Ala Asp Glu Arg Phe Val Ser Ala 
            340                 345                 350         


Ile Glu Gly Met His Pro Asn Gln Glu Asp His Glu Thr Phe Val Asp 
        355                 360                 365             


Ile Asn Pro Leu Thr Gly Ile Ile Leu Lys Ala Ala Lys Arg Phe Gln 
    370                 375                 380                 


Ile Asn Ile Tyr Val Lys Lys Leu Asp Asp Phe Val Glu Thr Gly Asp 
385                 390                 395                 400 


Ile Arg Thr Met Val Phe Pro Val Met Tyr Leu Asn Glu Ser Val His 
                405                 410                 415     


Ile Asp Lys Glu Thr Ala Ser Arg Leu Lys Ser Met Ile Asn Thr Thr 
            420                 425                 430         


Leu Ile Ile Thr Asn Ile Pro Tyr Ile Ile Met Ala Leu Gly Val Phe 
        435                 440                 445             


Phe Gly Leu Val Phe Thr Trp Leu Ala Cys Lys Gly Gln Gly Ser Met 
    450                 455                 460                 


Asp Glu Gly Thr Ala Asp Glu Arg Ala Pro Leu Ile Arg Thr 
465                 470                 475             


<210>  3301
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  3301

Met Asn Pro Thr Asp Ile Ala Asp Thr Thr Leu Asp Glu Ser Ile Tyr 
1               5                   10                  15      


Ser Asn Tyr Tyr Leu Tyr Glu Ser Ile Pro Lys Pro Cys Thr Lys Glu 
            20                  25                  30          


Gly Ile Lys Ala Phe Gly Glu Leu Phe Leu Pro Pro Leu Tyr Ser Leu 
        35                  40                  45              


Val Phe Val Phe Gly Leu Leu Gly Asn Ser Val Val Val Leu Val Leu 
    50                  55                  60                  


Phe Lys Tyr Lys Arg Leu Arg Ser Met Thr Asp Val Tyr Leu Leu Asn 
65                  70                  75                  80  


Leu Ala Ile Ser Asp Leu Leu Phe Val Phe Ser Leu Pro Phe Trp Gly 
                85                  90                  95      


Tyr Tyr Ala Ala Asp Gln Trp Val Phe Gly Leu Gly Leu Cys Lys Met 
            100                 105                 110         


Ile Ser Trp Met Tyr Leu Val Gly Phe Tyr Ser Gly Ile Phe Phe Val 
        115                 120                 125             


Met Leu Met Ser Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe 
    130                 135                 140                 


Ser Leu Arg Ala Arg Thr Leu Thr Tyr Gly Val Ile Thr Ser Leu Ala 
145                 150                 155                 160 


Thr Trp Ser Val Ala Val Phe Ala Ser Leu Pro Gly Phe Leu Phe Ser 
                165                 170                 175     


Thr Cys Tyr Thr Glu Arg Asn His Thr Tyr Cys Lys Thr Lys Tyr Ser 
            180                 185                 190         


Leu Asn Ser Thr Thr Trp Lys Val Leu Ser Ser Leu Glu Ile Asn Ile 
        195                 200                 205             


Leu Gly Leu Val Ile Pro Leu Gly Ile Met Leu Phe Cys Tyr Ser Met 
    210                 215                 220                 


Ile Ile Arg Thr Leu Gln His Cys Lys Asn Glu Lys Lys Asn Lys Ala 
225                 230                 235                 240 


Val Lys Met Ile Phe Ala Val Val Val Leu Phe Leu Gly Phe Trp Thr 
                245                 250                 255     


Pro Tyr Asn Ile Val Leu Phe Leu Glu Thr Leu Val Glu Leu Glu Val 
            260                 265                 270         


Leu Gln Asp Cys Thr Phe Glu Arg Tyr Leu Asp Tyr Ala Ile Gln Ala 
        275                 280                 285             


Thr Glu Thr Leu Ala Phe Val His Cys Cys Leu Asn Pro Ile Ile Tyr 
    290                 295                 300                 


Phe Phe Leu Gly Glu Lys Phe Arg Lys Tyr Ile Leu Gln Leu Phe Lys 
305                 310                 315                 320 


Thr Cys Arg Gly Leu Phe Val Leu Cys Gln Tyr Cys Gly Leu Leu Gln 
                325                 330                 335     


Ile Tyr Ser Ala Asp Thr Pro Ser Ser Ser Tyr Thr Gln Ser Thr Met 
            340                 345                 350         


Asp His Asp Leu His Asp Ala Leu 
        355                 360 


<210>  3302
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  3302

Met Pro Arg Glu Asp Ala His Phe Ile Tyr Gly Tyr Pro Lys Lys Gly 
1               5                   10                  15      


His Gly His Ser Tyr Thr Thr Ala Glu Glu Ala Ala Gly Ile Gly Ile 
            20                  25                  30          


Leu Thr Val Ile Leu Gly Val Leu Leu Leu Ile Gly Cys Trp Tyr Cys 
        35                  40                  45              


Arg Arg Arg Asn Gly Tyr Arg Ala Leu Met Asp Lys Ser Leu His Val 
    50                  55                  60                  


Gly Thr Gln Cys Ala Leu Thr Arg Arg Cys Pro Gln Glu Gly Phe Asp 
65                  70                  75                  80  


His Arg Asp Ser Lys Val Ser Leu Gln Glu Lys Asn Cys Glu Pro Val 
                85                  90                  95      


Val Pro Asn Ala Pro Pro Ala Tyr Glu Lys Leu Ser Ala Glu Gln Ser 
            100                 105                 110         


Pro Pro Pro Tyr Ser Pro 
        115             


<210>  3303
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  3303

Met Arg Pro Gln Ile Leu Leu Leu Leu Ala Leu Leu Thr Leu Gly Leu 
1               5                   10                  15      


Ala Ala Gln His Gln Asp Lys Val Pro Cys Lys Met Val Asp Lys Lys 
            20                  25                  30          


Val Ser Cys Gln Val Leu Gly Leu Leu Gln Val Pro Ser Val Leu Pro 
        35                  40                  45              


Pro Asp Thr Glu Thr Leu Asp Leu Ser Gly Asn Gln Leu Arg Ser Ile 
    50                  55                  60                  


Leu Ala Ser Pro Leu Gly Phe Tyr Thr Ala Leu Arg His Leu Asp Leu 
65                  70                  75                  80  


Ser Thr Asn Glu Ile Ser Phe Leu Gln Pro Gly Ala Phe Gln Ala Leu 
                85                  90                  95      


Thr His Leu Glu His Leu Ser Leu Ala His Asn Arg Leu Ala Met Ala 
            100                 105                 110         


Thr Ala Leu Ser Ala Gly Gly Leu Gly Pro Leu Pro Arg Val Thr Ser 
        115                 120                 125             


Leu Asp Leu Ser Gly Asn Ser Leu Tyr Ser Gly Leu Leu Glu Arg Leu 
    130                 135                 140                 


Leu Gly Glu Ala Pro Ser Leu His Thr Leu Ser Leu Ala Glu Asn Ser 
145                 150                 155                 160 


Leu Thr Arg Leu Thr Arg His Thr Phe Arg Asp Met Pro Ala Leu Glu 
                165                 170                 175     


Gln Leu Asp Leu His Ser Asn Val Leu Met Asp Ile Glu Asp Gly Ala 
            180                 185                 190         


Phe Glu Gly Leu Pro Arg Leu Thr His Leu Asn Leu Ser Arg Asn Ser 
        195                 200                 205             


Leu Thr Cys Ile Ser Asp Phe Ser Leu Gln Gln Leu Arg Val Leu Asp 
    210                 215                 220                 


Leu Ser Cys Asn Ser Ile Glu Ala Phe Gln Thr Ala Ser Gln Pro Gln 
225                 230                 235                 240 


Ala Glu Phe Gln Leu Thr Trp Leu Asp Leu Arg Glu Asn Lys Leu Leu 
                245                 250                 255     


His Phe Pro Asp Leu Ala Ala Leu Pro Arg Leu Ile Tyr Leu Asn Leu 
            260                 265                 270         


Ser Asn Asn Leu Ile Arg Leu Pro Thr Gly Pro Pro Gln Asp Ser Lys 
        275                 280                 285             


Gly Ile His Ala Pro Ser Glu Gly Trp Ser Ala Leu Pro Leu Ser Ala 
    290                 295                 300                 


Pro Ser Gly Asn Ala Ser Gly Arg Pro Leu Ser Gln Leu Leu Asn Leu 
305                 310                 315                 320 


Asp Leu Ser Tyr Asn Glu Ile Glu Leu Ile Pro Asp Ser Phe Leu Glu 
                325                 330                 335     


His Leu Thr Ser Leu Cys Phe Leu Asn Leu Ser Arg Asn Cys Leu Arg 
            340                 345                 350         


Thr Phe Glu Ala Arg Arg Leu Gly Ser Leu Pro Cys Leu Met Leu Leu 
        355                 360                 365             


Asp Leu Ser His Asn Ala Leu Glu Thr Leu Glu Leu Gly Ala Arg Ala 
    370                 375                 380                 


Leu Gly Ser Leu Arg Thr Leu Leu Leu Gln Gly Asn Ala Leu Arg Asp 
385                 390                 395                 400 


Leu Pro Pro Tyr Thr Phe Ala Asn Leu Ala Ser Leu Gln Arg Leu Asn 
                405                 410                 415     


Leu Gln Gly Asn Arg Val Ser Pro Cys Gly Gly Pro Asp Glu Pro Gly 
            420                 425                 430         


Pro Ser Gly Cys Val Ala Phe Ser Gly Ile Thr Ser Leu Arg Ser Leu 
        435                 440                 445             


Ser Leu Val Asp Asn Glu Ile Glu Leu Leu Arg Ala Gly Ala Phe Leu 
    450                 455                 460                 


His Thr Pro Leu Thr Glu Leu Asp Leu Ser Ser Asn Pro Gly Leu Glu 
465                 470                 475                 480 


Val Ala Thr Gly Ala Leu Gly Gly Leu Glu Ala Ser Leu Glu Val Leu 
                485                 490                 495     


Ala Leu Gln Gly Asn Gly Leu Met Val Leu Gln Val Asp Leu Pro Cys 
            500                 505                 510         


Phe Ile Cys Leu Lys Arg Leu Asn Leu Ala Glu Asn Arg Leu Ser His 
        515                 520                 525             


Leu Pro Ala Trp Thr Gln Ala Val Ser Leu Glu Val Leu Asp Leu Arg 
    530                 535                 540                 


Asn Asn Ser Phe Ser Leu Leu Pro Gly Ser Ala Met Gly Gly Leu Glu 
545                 550                 555                 560 


Thr Ser Leu Arg Arg Leu Tyr Leu Gln Gly Asn Pro Leu Ser Cys Cys 
                565                 570                 575     


Gly Asn Gly Trp Leu Ala Ala Gln Leu His Gln Gly Arg Val Asp Val 
            580                 585                 590         


Asp Ala Thr Gln Asp Leu Ile Cys Arg Phe Ser Ser Gln Glu Glu Val 
        595                 600                 605             


Ser Leu Ser His Val Arg Pro Glu Asp Cys Glu Lys Gly Gly Leu Lys 
    610                 615                 620                 


Asn Ile Asn Leu Ile Ile Ile Leu Thr Phe Ile Leu Val Ser Ala Ile 
625                 630                 635                 640 


Leu Leu Thr Thr Leu Ala Ala Cys Cys Cys Val Arg Arg Gln Lys Phe 
                645                 650                 655     


Asn Gln Gln Tyr Lys Ala 
            660         


<210>  3304
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  3304

Met Arg Val Met Ala Pro Arg Ala Leu Leu Leu Leu Leu Ser Gly Gly 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Cys Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Asp Thr Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Gly Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Asn Tyr Lys Arg Gln Ala Gln 
                85                  90                  95      


Ala Asp Arg Val Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Asp Gly Ser His Thr Leu Gln Arg Met Tyr Gly Cys Asp Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr Asp Gln Ser Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Leu Glu Ala Ala Arg Ala 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Leu Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Met Gln His Glu 
        275                 280                 285             


Gly Leu Gln Glu Pro Leu Thr Leu Ser Trp Glu Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Ala Val Leu Val Val 
305                 310                 315                 320 


Leu Ala Val Leu Gly Ala Val Val Thr Ala Met Met Cys Arg Arg Lys 
                325                 330                 335     


Ser Ser Gly Gly Lys Gly Gly Ser Cys Ser Gln Ala Ala Cys Ser Asn 
            340                 345                 350         


Ser Ala Gln Gly Ser Asp Glu Ser Leu Ile Thr Cys Lys Ala 
        355                 360                 365     


<210>  3305
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  3305

Met Leu Val Met Ala Pro Arg Thr Val Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Tyr Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Asn Thr Gln Ile Tyr Lys Ala Gln Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Ser Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly His Asp Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 
                165                 170                 175     


Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Asp Lys Leu Glu Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  3306
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  3306

Met Val Asp Gly Thr Leu Leu Leu Leu Leu Ser Glu Ala Leu Ala Leu 
1               5                   10                  15      


Thr Gln Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe His Thr Ser 
            20                  25                  30          


Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr 
        35                  40                  45              


Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala Ala Ser Pro 
    50                  55                  60                  


Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly Ser Glu Tyr 
65                  70                  75                  80  


Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln Ile Phe Arg 
                85                  90                  95      


Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly 
            100                 105                 110         


Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly Pro Asp Gly 
        115                 120                 125             


Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val Asp Thr Ala 
145                 150                 155                 160 


Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu Ala Glu His 
                165                 170                 175     


Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu His Lys Tyr 
            180                 185                 190         


Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro Pro Lys Thr 
        195                 200                 205             


His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys 
    210                 215                 220                 


Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Gln 
225                 230                 235                 240 


Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro 
                245                 250                 255     


Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser 
            260                 265                 270         


Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro 
        275                 280                 285             


Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro Thr Ile Pro 
    290                 295                 300                 


Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser Val Val Ser 
305                 310                 315                 320 


Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser Ser Gly Gly 
                325                 330                 335     


Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser Ala Gln Gly 
            340                 345                 350         


Ser Glu Ser His Ser Leu 
        355             


<210>  3307
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  3307

Met Ala Phe Met Lys Lys Tyr Leu Leu Pro Ile Leu Gly Leu Phe Met 
1               5                   10                  15      


Ala Tyr Tyr Tyr Tyr Ser Ala Asn Glu Glu Phe Arg Pro Glu Met Leu 
            20                  25                  30          


Gln Gly Lys Lys Val Ile Val Thr Gly Ala Ser Lys Gly Ile Gly Arg 
        35                  40                  45              


Glu Met Ala Tyr His Leu Ala Lys Met Gly Ala His Val Val Val Thr 
    50                  55                  60                  


Ala Arg Ser Lys Glu Thr Leu Gln Lys Val Val Ser His Cys Leu Glu 
65                  70                  75                  80  


Leu Gly Ala Ala Ser Ala His Tyr Ile Ala Gly Thr Met Glu Asp Met 
                85                  90                  95      


Thr Phe Ala Glu Gln Phe Val Ala Gln Ala Gly Lys Leu Met Gly Gly 
            100                 105                 110         


Leu Asp Met Leu Ile Leu Asn His Ile Thr Asn Thr Ser Leu Asn Leu 
        115                 120                 125             


Phe His Asp Asp Ile His His Val Arg Lys Ser Met Glu Val Asn Phe 
    130                 135                 140                 


Leu Ser Tyr Val Val Leu Thr Val Ala Ala Leu Pro Met Leu Lys Gln 
145                 150                 155                 160 


Ser Asn Gly Ser Ile Val Val Val Ser Ser Leu Ala Gly Lys Val Ala 
                165                 170                 175     


Tyr Pro Met Val Ala Ala Tyr Ser Ala Ser Lys Phe Ala Leu Asp Gly 
            180                 185                 190         


Phe Phe Ser Ser Ile Arg Lys Glu Tyr Ser Val Ser Arg Val Asn Val 
        195                 200                 205             


Ser Ile Thr Leu Cys Val Leu Gly Leu Ile Asp Thr Glu Thr Ala Met 
    210                 215                 220                 


Lys Ala Val Ser Gly Ile Val His Met Gln Ala Ala Pro Lys Glu Glu 
225                 230                 235                 240 


Cys Ala Leu Glu Ile Ile Lys Gly Gly Ala Leu Arg Gln Glu Glu Val 
                245                 250                 255     


Tyr Tyr Asp Ser Ser Leu Trp Thr Thr Leu Leu Ile Arg Asn Pro Cys 
            260                 265                 270         


Arg Lys Ile Leu Glu Phe Leu Tyr Ser Thr Ser Tyr Asn Met Asp Arg 
        275                 280                 285             


Phe Ile Asn Lys 
    290         


<210>  3308
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  3308

Met Pro Pro Leu Leu Pro Leu Arg Leu Cys Arg Leu Trp Pro Arg Asn 
1               5                   10                  15      


Pro Pro Ser Arg Leu Leu Gly Ala Ala Ala Gly Gln Arg Ser Arg Pro 
            20                  25                  30          


Ser Thr Tyr Tyr Glu Leu Leu Gly Val His Pro Gly Ala Ser Thr Glu 
        35                  40                  45              


Glu Val Lys Arg Ala Phe Phe Ser Lys Ser Lys Glu Leu His Pro Asp 
    50                  55                  60                  


Arg Asp Pro Gly Asn Pro Ser Leu His Ser Arg Phe Val Glu Leu Ser 
65                  70                  75                  80  


Glu Ala Tyr Arg Val Leu Ser Arg Glu Gln Ser Arg Arg Ser Tyr Asp 
                85                  90                  95      


Asp Gln Leu Arg Ser Gly Ser Pro Pro Lys Ser Pro Arg Thr Thr Val 
            100                 105                 110         


His Asp Lys Ser Ala His Gln Thr His Ser Ser Trp Thr Pro Pro Asn 
        115                 120                 125             


Ala Gln Tyr Trp Ser Gln Phe His Ser Val Arg Pro Gln Gly Pro Gln 
    130                 135                 140                 


Leu Arg Gln Gln Gln His Lys Gln Asn Lys Gln Val Leu Gly Tyr Cys 
145                 150                 155                 160 


Leu Leu Leu Met Leu Ala Gly Met Gly Leu His Tyr Ile Ala Phe Arg 
                165                 170                 175     


Lys Val Lys Gln Met His Leu Asn Phe Met Asp Glu Lys Asp Arg Ile 
            180                 185                 190         


Ile Thr Ala Phe Tyr Asn Glu Ala Arg Ala Arg Ala Arg Ala Asn Arg 
        195                 200                 205             


Gly Ile Leu Gln Gln Glu Arg Gln Arg Leu Gly Gln Arg Gln Pro Pro 
    210                 215                 220                 


Pro Ser Glu Pro Thr Gln Gly Pro Glu Ile Val Pro Arg Gly Ala Gly 
225                 230                 235                 240 


Pro 
    


<210>  3309
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  3309

Met Glu Ala Ser Ala Leu Thr Ser Ser Ala Val Thr Ser Val Ala Lys 
1               5                   10                  15      


Val Val Arg Val Ala Ser Gly Ser Ala Val Val Leu Pro Leu Ala Arg 
            20                  25                  30          


Ile Ala Thr Val Val Ile Gly Gly Val Val Ala Val Pro Met Val Leu 
        35                  40                  45              


Ser Ala Met Gly Phe Thr Ala Ala Gly Ile Ala Ser Ser Ser Ile Ala 
    50                  55                  60                  


Ala Lys Met Met Ser Ala Ala Ala Ile Ala Asn Gly Gly Gly Val Ala 
65                  70                  75                  80  


Ser Gly Ser Leu Val Ala Thr Leu Gln Ser Leu Gly Ala Thr Gly Leu 
                85                  90                  95      


Ser Gly Leu Thr Lys Phe Ile Leu Gly Ser Ile Gly Ser Ala Ile Ala 
            100                 105                 110         


Ala Val Ile Ala Arg Phe Tyr 
        115                 


<210>  3310
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  3310

Met Arg Pro Thr Leu Leu Trp Ser Leu Leu Leu Leu Leu Gly Val Phe 
1               5                   10                  15      


Ala Ala Ala Ala Ala Ala Pro Pro Asp Pro Leu Ser Gln Leu Pro Ala 
            20                  25                  30          


Pro Gln His Pro Lys Ile Arg Leu Tyr Asn Ala Glu Gln Val Leu Ser 
        35                  40                  45              


Trp Glu Pro Val Ala Leu Ser Asn Ser Thr Arg Pro Val Val Tyr Gln 
    50                  55                  60                  


Val Gln Phe Lys Tyr Thr Asp Ser Lys Trp Phe Thr Ala Asp Ile Met 
65                  70                  75                  80  


Ser Ile Gly Val Asn Cys Thr Gln Ile Thr Ala Thr Glu Cys Asp Phe 
                85                  90                  95      


Thr Ala Ala Ser Pro Ser Ala Gly Phe Pro Met Asp Phe Asn Val Thr 
            100                 105                 110         


Leu Arg Leu Arg Ala Glu Leu Gly Ala Leu His Ser Ala Trp Val Thr 
        115                 120                 125             


Met Pro Trp Phe Gln His Tyr Arg Asn Val Thr Val Gly Pro Pro Glu 
    130                 135                 140                 


Asn Ile Glu Val Thr Pro Gly Glu Gly Ser Leu Ile Ile Arg Phe Ser 
145                 150                 155                 160 


Ser Pro Phe Asp Ile Ala Asp Thr Ser Thr Ala Phe Phe Cys Tyr Tyr 
                165                 170                 175     


Val His Tyr Trp Glu Lys Gly Gly Ile Gln Gln Val Lys Gly Pro Phe 
            180                 185                 190         


Arg Ser Asn Ser Ile Ser Leu Asp Asn Leu Lys Pro Ser Arg Val Tyr 
        195                 200                 205             


Cys Leu Gln Val Gln Ala Gln Leu Leu Trp Asn Lys Ser Asn Ile Phe 
    210                 215                 220                 


Arg Val Gly His Leu Ser Asn Ile Ser Cys Tyr Glu Thr Met Ala Asp 
225                 230                 235                 240 


Ala Ser Thr Glu Leu Gln Gln Val Ile Leu Ile Ser Val Gly Thr Phe 
                245                 250                 255     


Ser Leu Leu Ser Val Leu Ala Gly Ala Cys Phe Phe Leu Val Leu Lys 
            260                 265                 270         


Tyr Arg Gly Leu Ile Lys Tyr Trp Phe His Thr Pro Pro Ser Ile Pro 
        275                 280                 285             


Leu Gln Ile Glu Glu Tyr Leu Lys Asp Pro Thr Gln Pro Ile Leu Glu 
    290                 295                 300                 


Ala Leu Asp Lys Asp Ser Ser Pro Lys Asp Asp Val Trp Asp Ser Val 
305                 310                 315                 320 


Ser Ile Ile Ser Phe Pro Glu Lys Glu Gln Glu Asp Val Leu Gln Thr 
                325                 330                 335     


Leu 
    


<210>  3311
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  3311

Met Glu Pro Leu Val Thr Trp Val Val Pro Leu Leu Phe Leu Phe Leu 
1               5                   10                  15      


Leu Ser Arg Gln Gly Ala Ala Cys Arg Thr Ser Glu Cys Cys Phe Gln 
            20                  25                  30          


Asp Pro Pro Tyr Pro Asp Ala Asp Ser Gly Ser Ala Ser Gly Pro Arg 
        35                  40                  45              


Asp Leu Arg Cys Tyr Arg Ile Ser Ser Asp Arg Tyr Glu Cys Ser Trp 
    50                  55                  60                  


Gln Tyr Glu Gly Pro Thr Ala Gly Val Ser His Phe Leu Arg Cys Cys 
65                  70                  75                  80  


Leu Ser Ser Gly Arg Cys Cys Tyr Phe Ala Ala Gly Ser Ala Thr Arg 
                85                  90                  95      


Leu Gln Phe Ser Asp Gln Ala Gly Val Ser Val Leu Tyr Thr Val Thr 
            100                 105                 110         


Leu Trp Val Glu Ser Trp Ala Arg Asn Gln Thr Glu Lys Ser Pro Glu 
        115                 120                 125             


Val Thr Leu Gln Leu Tyr Asn Ser Val Lys Tyr Glu Pro Pro Leu Gly 
    130                 135                 140                 


Asp Ile Lys Val Ser Lys Leu Ala Gly Gln Leu Arg Met Glu Trp Glu 
145                 150                 155                 160 


Thr Pro Asp Asn Gln Val Gly Ala Glu Val Gln Phe Arg His Arg Thr 
                165                 170                 175     


Pro Ser Ser Pro Trp Lys Leu Gly Asp Cys Gly Pro Gln Asp Asp Asp 
            180                 185                 190         


Thr Glu Ser Cys Leu Cys Pro Leu Glu Met Asn Val Ala Gln Glu Phe 
        195                 200                 205             


Gln Leu Arg Arg Arg Gln Leu Gly Ser Gln Gly Ser Ser Trp Ser Lys 
    210                 215                 220                 


Trp Ser Ser Pro Val Cys Val Pro Pro Glu Asn Pro Pro Gln Pro Gln 
225                 230                 235                 240 


Val Arg Phe Ser Val Glu Gln Leu Gly Gln Asp Gly Arg Arg Arg Leu 
                245                 250                 255     


Thr Leu Lys Glu Gln Pro Thr Gln Leu Glu Leu Pro Glu Gly Cys Gln 
            260                 265                 270         


Gly Leu Ala Pro Gly Thr Glu Val Thr Tyr Arg Leu Gln Leu His Met 
        275                 280                 285             


Leu Ser Cys Pro Cys Lys Ala Lys Ala Thr Arg Thr Leu His Leu Gly 
    290                 295                 300                 


Lys Met Pro Tyr Leu Ser Gly Ala Ala Tyr Asn Val Ala Val Ile Ser 
305                 310                 315                 320 


Ser Asn Gln Phe Gly Pro Gly Leu Asn Gln Thr Trp His Ile Pro Ala 
                325                 330                 335     


Asp Thr His Thr Glu Pro Val Ala Leu Asn Ile Ser Val Gly Thr Asn 
            340                 345                 350         


Gly Thr Thr Met Tyr Trp Pro Ala Arg Ala Gln Ser Met Thr Tyr Cys 
        355                 360                 365             


Ile Glu Trp Gln Pro Val Gly Gln Asp Gly Gly Leu Ala Thr Cys Ser 
    370                 375                 380                 


Leu Thr Ala Pro Gln Asp Pro Asp Pro Ala Gly Met Ala Thr Tyr Ser 
385                 390                 395                 400 


Trp Ser Arg Glu Ser Gly Ala Met Gly Gln Glu Lys Cys Tyr Tyr Ile 
                405                 410                 415     


Thr Ile Phe Ala Ser Ala His Pro Glu Lys Leu Thr Leu Trp Ser Thr 
            420                 425                 430         


Val Leu Ser Thr Tyr His Phe Gly Gly Asn Ala Ser Ala Ala Gly Thr 
        435                 440                 445             


Pro His His Val Ser Val Lys Asn His Ser Leu Asp Ser Val Ser Val 
    450                 455                 460                 


Asp Trp Ala Pro Ser Leu Leu Ser Thr Cys Pro Gly Val Leu Lys Glu 
465                 470                 475                 480 


Tyr Val Val Arg Cys Arg Asp Glu Asp Ser Lys Gln Val Ser Glu His 
                485                 490                 495     


Pro Val Gln Pro Thr Glu Thr Gln Val Thr Leu Ser Gly Leu Arg Ala 
            500                 505                 510         


Gly Val Ala Tyr Thr Val Gln Val Arg Ala Asp Thr Ala Trp Leu Arg 
        515                 520                 525             


Gly Val Trp Ser Gln Pro Gln Arg Phe Ser Ile Glu Val Gln Val Ser 
    530                 535                 540                 


Asp Trp Leu Ile Phe Phe Ala Ser Leu Gly Ser Phe Leu Ser Ile Leu 
545                 550                 555                 560 


Leu Val Gly Val Leu Gly Tyr Leu Gly Leu Asn Arg Ala Ala Arg His 
                565                 570                 575     


Leu Cys Pro Pro Leu Pro Thr Pro Cys Ala Ser Ser Ala Ile Glu Phe 
            580                 585                 590         


Pro Gly Gly Lys Glu Thr Trp Gln Trp Ile Asn Pro Val Asp Phe Gln 
        595                 600                 605             


Glu Glu Ala Ser Leu Gln Glu Ala Leu Val Val Glu Met Ser Trp Asp 
    610                 615                 620                 


Lys Gly Glu Arg Thr Glu Pro Leu Glu Lys Thr Glu Leu Pro Glu Gly 
625                 630                 635                 640 


Ala Pro Glu Leu Ala Leu Asp Thr Glu Leu Ser Leu Glu Asp Gly Asp 
                645                 650                 655     


Arg Cys Lys Ala Lys Met 
            660         


<210>  3312
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  3312

Met Pro Arg Leu His Asp His Phe Trp Ser Cys Ser Cys Ala His Ser 
1               5                   10                  15      


Ala Arg Arg Arg Gly Pro Pro Arg Ala Ser Ala Ala Gly Leu Ala Ala 
            20                  25                  30          


Lys Val Gly Glu Met Ile Asn Val Ser Val Ser Gly Pro Ser Leu Leu 
        35                  40                  45              


Ala Ala His Gly Ala Pro Asp Ala Asp Pro Ala Pro Arg Gly Arg Ser 
    50                  55                  60                  


Ala Ala Met Ser Gly Pro Glu Pro Gly Ser Pro Tyr Pro Asn Thr Trp 
65                  70                  75                  80  


His His Arg Leu Leu Gln Arg Ser Leu Val Leu Phe Ser Val Gly Val 
                85                  90                  95      


Val Leu Ala Leu Val Leu Asn Leu Leu Gln Ile Gln Arg Asn Val Thr 
            100                 105                 110         


Leu Phe Pro Glu Glu Val Ile Ala Thr Ile Phe Ser Ser Ala Trp Trp 
        115                 120                 125             


Val Pro Pro Cys Cys Gly Thr Ala Ala Ala Val Val Gly Leu Leu Tyr 
    130                 135                 140                 


Pro Cys Ile Asp Ser His Leu Gly Glu Pro His Lys Phe Lys Arg Glu 
145                 150                 155                 160 


Trp Ala Ser Val Met Arg Cys Ile Ala Val Phe Val Gly Ile Asn His 
                165                 170                 175     


Ala Ser Ala Lys Leu Asp Phe Ala Asn Asn Val Gln Leu Ser Leu Thr 
            180                 185                 190         


Leu Ala Ala Leu Ser Leu Gly Leu Trp Trp Thr Phe Asp Arg Ser Arg 
        195                 200                 205             


Ser Gly Leu Gly Leu Gly Ile Thr Ile Ala Phe Leu Ala Thr Leu Ile 
    210                 215                 220                 


Thr Gln Phe Leu Val Tyr Asn Gly Val Tyr Gln Tyr Thr Ser Pro Asp 
225                 230                 235                 240 


Phe Leu Tyr Ile Arg Ser Trp Leu Pro Cys Ile Phe Phe Ser Gly Gly 
                245                 250                 255     


Val Thr Val Gly Asn Ile Gly Arg Gln Leu Ala Met Gly Val Pro Glu 
            260                 265                 270         


Lys Pro His Ser Asp 
        275         


<210>  3313
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  3313

Met Asp Pro Arg Leu Pro Ala Trp Ala Leu Val Leu Leu Gly Pro Ala 
1               5                   10                  15      


Leu Val Phe Ala Leu Gly Pro Ala Pro Thr Pro Glu Met Arg Glu Lys 
            20                  25                  30          


Leu Cys Gly His His Phe Val Arg Ala Leu Val Arg Val Cys Gly Gly 
        35                  40                  45              


Pro Arg Trp Ser Thr Glu Ala Arg Arg Pro Ala Thr Gly Gly Asp Arg 
    50                  55                  60                  


Glu Leu Leu Gln Trp Leu Glu Arg Arg His Leu Leu His Gly Leu Val 
65                  70                  75                  80  


Ala Asp Ser Asn Leu Thr Leu Gly Pro Gly Leu Gln Pro Leu Pro Gln 
                85                  90                  95      


Thr Ser His His His Arg His His Arg Ala Ala Ala Thr Asn Pro Ala 
            100                 105                 110         


Arg Tyr Cys Cys Leu Ser Gly Cys Thr Gln Gln Asp Leu Leu Thr Leu 
        115                 120                 125             


Cys Pro Tyr 
    130     


<210>  3314
<211>  511
<212>  PRT
<213>  Homo sapiens

<400>  3314

Met Asp Val Cys Gly Trp Lys Glu Met Glu Val Ala Leu Val Asn Phe 
1               5                   10                  15      


Asp Asn Ser Asp Glu Ile Gln Glu Glu Pro Gly Tyr Ala Thr Asp Phe 
            20                  25                  30          


Asp Ser Thr Ser Pro Lys Gly Arg Pro Gly Gly Ser Ser Phe Ser Asn 
        35                  40                  45              


Gly Lys Ile Leu Ile Ser Glu Ser Thr Asn His Glu Thr Ala Phe Ser 
    50                  55                  60                  


Lys Leu Pro Gly Asp Tyr Ala Asp Pro Pro Gly Pro Glu Pro Val Val 
65                  70                  75                  80  


Leu Asn Glu Gly Asn Gln Arg Val Ile Ile Asn Ile Ala Gly Leu Arg 
                85                  90                  95      


Phe Glu Thr Gln Leu Arg Thr Leu Ser Gln Phe Pro Glu Thr Leu Leu 
            100                 105                 110         


Gly Asp Arg Glu Lys Arg Met Gln Phe Phe Asp Ser Met Arg Asn Glu 
        115                 120                 125             


Tyr Phe Phe Asp Arg Asn Arg Pro Ser Phe Asp Gly Ile Leu Tyr Tyr 
    130                 135                 140                 


Tyr Gln Ser Gly Gly Lys Ile Arg Arg Pro Ala Asn Val Pro Ile Asp 
145                 150                 155                 160 


Ile Phe Ala Asp Glu Ile Ser Phe Tyr Glu Leu Gly Ser Glu Ala Met 
                165                 170                 175     


Asp Gln Phe Arg Glu Asp Glu Gly Phe Ile Lys Asp Pro Glu Thr Leu 
            180                 185                 190         


Leu Pro Thr Asn Asp Ile His Arg Gln Phe Trp Leu Leu Phe Glu Tyr 
        195                 200                 205             


Pro Glu Ser Ser Ser Ala Ala Arg Ala Val Ala Val Val Ser Val Leu 
    210                 215                 220                 


Val Val Val Ile Ser Ile Thr Ile Phe Cys Leu Glu Thr Leu Pro Glu 
225                 230                 235                 240 


Phe Arg Glu Asp Arg Glu Leu Lys Val Val Arg Asp Pro Asn Leu Asn 
                245                 250                 255     


Met Ser Lys Thr Val Leu Ser Gln Thr Met Phe Thr Asp Pro Phe Phe 
            260                 265                 270         


Met Val Glu Ser Thr Cys Ile Val Trp Phe Thr Phe Glu Leu Val Leu 
        275                 280                 285             


Arg Phe Val Val Cys Pro Ser Lys Thr Asp Phe Phe Arg Asn Ile Met 
    290                 295                 300                 


Asn Ile Ile Asp Ile Ile Ser Ile Ile Pro Tyr Phe Ala Thr Leu Ile 
305                 310                 315                 320 


Thr Glu Leu Val Gln Glu Thr Glu Pro Ser Ala Gln Gln Asn Met Ser 
                325                 330                 335     


Leu Ala Ile Leu Arg Ile Ile Arg Leu Val Arg Val Phe Arg Ile Phe 
            340                 345                 350         


Lys Leu Ser Arg His Ser Lys Gly Leu Gln Ile Leu Gly Gln Thr Leu 
        355                 360                 365             


Lys Ala Ser Met Arg Glu Leu Gly Leu Leu Ile Phe Phe Leu Phe Ile 
    370                 375                 380                 


Gly Val Ile Leu Phe Ser Ser Ala Val Tyr Phe Ala Glu Val Asp Glu 
385                 390                 395                 400 


Pro Glu Ser His Phe Ser Ser Ile Pro Asp Gly Phe Trp Trp Ala Val 
                405                 410                 415     


Val Thr Met Thr Thr Val Gly Tyr Gly Asp Met Cys Pro Thr Thr Pro 
            420                 425                 430         


Gly Gly Lys Ile Val Gly Thr Leu Cys Ala Ile Ala Gly Val Leu Thr 
        435                 440                 445             


Ile Ala Leu Pro Val Pro Val Ile Val Ser Asn Phe Asn Tyr Phe Tyr 
    450                 455                 460                 


His Arg Glu Thr Glu Asn Glu Glu Lys Gln Asn Ile Pro Gly Glu Ile 
465                 470                 475                 480 


Glu Arg Ile Leu Asn Ser Val Gly Ser Arg Met Gly Ser Thr Asp Ser 
                485                 490                 495     


Leu Asn Lys Thr Asn Gly Gly Cys Ser Thr Glu Lys Ser Arg Lys 
            500                 505                 510     


<210>  3315
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  3315

Met Ala Ala Pro Gly Ser Ala Arg Arg Pro Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Gly Leu Met His Cys Ala Ser Ala Ala Met Phe Met 
            20                  25                  30          


Val Lys Asn Gly Asn Gly Thr Ala Cys Ile Met Ala Asn Phe Ser Ala 
        35                  40                  45              


Ala Phe Ser Val Asn Tyr Asp Thr Lys Ser Gly Pro Lys Asn Met Thr 
    50                  55                  60                  


Phe Asp Leu Pro Ser Asp Ala Thr Val Val Leu Asn Arg Ser Ser Cys 
65                  70                  75                  80  


Gly Lys Glu Asn Thr Ser Asp Pro Ser Leu Val Ile Ala Phe Gly Arg 
                85                  90                  95      


Gly His Thr Leu Thr Leu Asn Phe Thr Arg Asn Ala Thr Arg Tyr Ser 
            100                 105                 110         


Val Gln Leu Met Ser Phe Val Tyr Asn Leu Ser Asp Thr His Leu Phe 
        115                 120                 125             


Pro Asn Ala Ser Ser Lys Glu Ile Lys Thr Val Glu Ser Ile Thr Asp 
    130                 135                 140                 


Ile Arg Ala Asp Ile Asp Lys Lys Tyr Arg Cys Val Ser Gly Thr Gln 
145                 150                 155                 160 


Val His Met Asn Asn Val Thr Val Thr Leu His Asp Ala Thr Ile Gln 
                165                 170                 175     


Ala Tyr Leu Ser Asn Ser Ser Phe Ser Arg Gly Glu Thr Arg Cys Glu 
            180                 185                 190         


Gln Asp Arg Pro Ser Pro Thr Thr Ala Pro Pro Ala Pro Pro Ser Pro 
        195                 200                 205             


Ser Pro Ser Pro Val Pro Lys Ser Pro Ser Val Asp Lys Tyr Asn Val 
    210                 215                 220                 


Ser Gly Thr Asn Gly Thr Cys Leu Leu Ala Ser Met Gly Leu Gln Leu 
225                 230                 235                 240 


Asn Leu Thr Tyr Glu Arg Lys Asp Asn Thr Thr Val Thr Arg Leu Leu 
                245                 250                 255     


Asn Ile Asn Pro Asn Lys Thr Ser Ala Ser Gly Ser Cys Gly Ala His 
            260                 265                 270         


Leu Val Thr Leu Glu Leu His Ser Glu Gly Thr Thr Val Leu Leu Phe 
        275                 280                 285             


Gln Phe Gly Met Asn Ala Ser Ser Ser Arg Phe Phe Leu Gln Gly Ile 
    290                 295                 300                 


Gln Leu Asn Thr Ile Leu Pro Asp Ala Arg Asp Pro Ala Phe Lys Ala 
305                 310                 315                 320 


Ala Asn Gly Ser Leu Arg Ala Leu Gln Ala Thr Val Gly Asn Ser Tyr 
                325                 330                 335     


Lys Cys Asn Ala Glu Glu His Val Arg Val Thr Lys Ala Phe Ser Val 
            340                 345                 350         


Asn Ile Phe Lys Val Trp Val Gln Ala Phe Lys Val Glu Gly Gly Gln 
        355                 360                 365             


Phe Gly Ser Val Glu Glu Cys Leu Leu Asp Glu Asn Ser Met Leu Ile 
    370                 375                 380                 


Pro Ile Ala Val Gly Gly Ala Leu Ala Gly Leu Val Leu Ile Val Leu 
385                 390                 395                 400 


Ile Ala Tyr Leu Val Gly Arg Lys Arg Ser His Ala Gly Tyr Gln Thr 
                405                 410                 415     


Ile 
    


<210>  3316
<211>  1025
<212>  PRT
<213>  Homo sapiens

<400>  3316

Met Glu Pro Phe Thr Asn Asp Arg Leu Gln Leu Pro Arg Asn Met Ile 
1               5                   10                  15      


Glu Asn Ser Met Phe Glu Glu Glu Pro Asp Val Val Asp Leu Ala Lys 
            20                  25                  30          


Glu Pro Cys Leu His Pro Leu Glu Pro Asp Glu Val Glu Tyr Glu Pro 
        35                  40                  45              


Arg Gly Ser Arg Leu Leu Val Arg Gly Leu Gly Glu His Glu Met Glu 
    50                  55                  60                  


Glu Asp Glu Glu Asp Tyr Glu Ser Ser Ala Lys Leu Leu Gly Met Ser 
65                  70                  75                  80  


Phe Met Asn Arg Ser Ser Gly Leu Arg Asn Ser Ala Thr Gly Tyr Arg 
                85                  90                  95      


Gln Ser Pro Asp Gly Ala Cys Ser Val Pro Ser Ala Arg Thr Met Val 
            100                 105                 110         


Val Cys Ala Phe Val Ile Val Val Ala Val Ser Val Ile Met Val Ile 
        115                 120                 125             


Tyr Leu Leu Pro Arg Cys Thr Phe Thr Lys Glu Gly Cys His Lys Lys 
    130                 135                 140                 


Asn Gln Ser Ile Gly Leu Ile Gln Pro Phe Ala Thr Asn Gly Lys Leu 
145                 150                 155                 160 


Phe Pro Trp Ala Gln Ile Arg Leu Pro Thr Ala Val Val Pro Leu Arg 
                165                 170                 175     


Tyr Glu Leu Ser Leu His Pro Asn Leu Thr Ser Met Thr Phe Arg Gly 
            180                 185                 190         


Ser Val Thr Ile Ser Val Gln Ala Leu Gln Val Thr Trp Asn Ile Ile 
        195                 200                 205             


Leu His Ser Thr Gly His Asn Ile Ser Arg Val Thr Phe Met Ser Ala 
    210                 215                 220                 


Val Ser Ser Gln Glu Lys Gln Ala Glu Ile Leu Glu Tyr Ala Tyr His 
225                 230                 235                 240 


Gly Gln Ile Ala Ile Val Ala Pro Glu Ala Leu Leu Ala Gly His Asn 
                245                 250                 255     


Tyr Thr Leu Lys Ile Glu Tyr Ser Ala Asn Ile Ser Ser Ser Tyr Tyr 
            260                 265                 270         


Gly Phe Tyr Gly Phe Ser Tyr Thr Asp Glu Ser Asn Glu Lys Lys Tyr 
        275                 280                 285             


Phe Ala Ala Thr Gln Phe Glu Pro Leu Ala Ala Arg Ser Ala Phe Pro 
    290                 295                 300                 


Cys Phe Asp Glu Pro Ala Phe Lys Ala Thr Phe Ile Ile Lys Ile Ile 
305                 310                 315                 320 


Arg Asp Glu Gln Tyr Thr Ala Leu Ser Asn Met Pro Lys Lys Ser Ser 
                325                 330                 335     


Val Val Leu Asp Asp Gly Leu Val Gln Asp Glu Phe Ser Glu Ser Val 
            340                 345                 350         


Lys Met Ser Thr Tyr Leu Val Ala Phe Ile Val Gly Glu Met Lys Asn 
        355                 360                 365             


Leu Ser Gln Asp Val Asn Gly Thr Leu Val Ser Ile Tyr Ala Val Pro 
    370                 375                 380                 


Glu Lys Ile Gly Gln Val His Tyr Ala Leu Glu Thr Thr Val Lys Leu 
385                 390                 395                 400 


Leu Glu Phe Phe Gln Asn Tyr Phe Glu Ile Gln Tyr Pro Leu Lys Lys 
                405                 410                 415     


Leu Asp Leu Val Ala Ile Pro Asp Phe Glu Ala Gly Ala Met Glu Asn 
            420                 425                 430         


Trp Gly Leu Leu Thr Phe Arg Glu Glu Thr Leu Leu Tyr Asp Ser Asn 
        435                 440                 445             


Thr Ser Ser Met Ala Asp Arg Lys Leu Val Thr Lys Ile Ile Ala His 
    450                 455                 460                 


Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr Met Lys Trp Trp 
465                 470                 475                 480 


Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Thr Phe Met Glu Tyr Phe 
                485                 490                 495     


Ser Leu Glu Lys Ile Phe Lys Glu Leu Ser Ser Tyr Glu Asp Phe Leu 
            500                 505                 510         


Asp Ala Arg Phe Lys Thr Met Lys Lys Asp Ser Leu Asn Ser Ser His 
        515                 520                 525             


Pro Ile Ser Ser Ser Val Gln Ser Ser Glu Gln Ile Glu Glu Met Phe 
    530                 535                 540                 


Asp Ser Leu Ser Tyr Phe Lys Gly Ser Ser Leu Leu Leu Met Leu Lys 
545                 550                 555                 560 


Thr Tyr Leu Ser Glu Asp Val Phe Gln His Ala Val Val Leu Tyr Leu 
                565                 570                 575     


His Asn His Ser Tyr Ala Ser Ile Gln Ser Asp Asp Leu Trp Asp Ser 
            580                 585                 590         


Phe Asn Glu Val Thr Asn Gln Thr Leu Asp Val Lys Arg Met Met Lys 
        595                 600                 605             


Thr Trp Thr Leu Gln Lys Gly Phe Pro Leu Val Thr Val Gln Lys Lys 
    610                 615                 620                 


Gly Lys Glu Leu Phe Ile Gln Gln Glu Arg Phe Phe Leu Asn Met Lys 
625                 630                 635                 640 


Pro Glu Ile Gln Pro Ser Asp Thr Ser Tyr Leu Trp His Ile Pro Leu 
                645                 650                 655     


Ser Tyr Val Thr Glu Gly Arg Asn Tyr Ser Lys Tyr Gln Ser Val Ser 
            660                 665                 670         


Leu Leu Asp Lys Lys Ser Gly Val Ile Asn Leu Thr Glu Glu Val Leu 
        675                 680                 685             


Trp Val Lys Val Asn Ile Asn Met Asn Gly Tyr Tyr Ile Val His Tyr 
    690                 695                 700                 


Ala Asp Asp Asp Trp Glu Ala Leu Ile His Gln Leu Lys Ile Asn Pro 
705                 710                 715                 720 


Tyr Val Leu Ser Asp Lys Asp Arg Ala Asn Leu Ile Asn Asn Ile Phe 
                725                 730                 735     


Glu Leu Ala Gly Leu Gly Lys Val Pro Leu Lys Arg Ala Phe Asp Leu 
            740                 745                 750         


Ile Asn Tyr Leu Gly Asn Glu Asn His Thr Ala Pro Ile Thr Glu Ala 
        755                 760                 765             


Leu Phe Gln Thr Asp Leu Ile Tyr Asn Leu Leu Glu Lys Leu Gly Tyr 
    770                 775                 780                 


Met Asp Leu Ala Ser Arg Leu Val Thr Arg Val Phe Lys Leu Leu Gln 
785                 790                 795                 800 


Asn Gln Ile Gln Gln Gln Thr Trp Thr Asp Glu Gly Thr Pro Ser Met 
                805                 810                 815     


Arg Glu Leu Arg Ser Ala Leu Leu Glu Phe Ala Cys Thr His Asn Leu 
            820                 825                 830         


Gly Asn Cys Ser Thr Thr Ala Met Lys Leu Phe Asp Asp Trp Met Ala 
        835                 840                 845             


Ser Asn Gly Thr Gln Ser Leu Pro Thr Asp Val Met Thr Thr Val Phe 
    850                 855                 860                 


Lys Val Gly Ala Lys Thr Asp Lys Gly Trp Ser Phe Leu Leu Gly Lys 
865                 870                 875                 880 


Tyr Ile Ser Ile Gly Ser Glu Ala Glu Lys Asn Lys Ile Leu Glu Ala 
                885                 890                 895     


Leu Ala Ser Ser Glu Asp Val Arg Lys Leu Tyr Trp Leu Met Lys Ser 
            900                 905                 910         


Ser Leu Asn Gly Asp Asn Phe Arg Thr Gln Lys Leu Ser Phe Ile Ile 
        915                 920                 925             


Arg Thr Val Gly Arg His Phe Pro Gly His Leu Leu Ala Trp Asp Phe 
    930                 935                 940                 


Val Lys Glu Asn Trp Asn Lys Leu Val Gln Lys Phe Pro Leu Gly Ser 
945                 950                 955                 960 


Tyr Thr Ile Gln Asn Ile Val Ala Gly Ser Thr Tyr Leu Phe Ser Thr 
                965                 970                 975     


Lys Thr His Leu Ser Glu Val Gln Ala Phe Phe Glu Asn Gln Ser Glu 
            980                 985                 990         


Ala Thr Phe Arg Leu Arg Cys Val  Gln Glu Ala Leu Glu  Val Ile Gln 
        995                 1000                 1005             


Leu Asn  Ile Gln Trp Met Glu  Lys Asn Leu Lys Ser  Leu Thr Trp 
    1010                 1015                 1020             


Trp Leu  
    1025 


<210>  3317
<211>  628
<212>  PRT
<213>  Homo sapiens

<400>  3317

Met Glu Pro Pro Asp Ala Pro Ala Gln Ala Arg Gly Ala Pro Arg Leu 
1               5                   10                  15      


Leu Leu Leu Ala Val Leu Leu Ala Ala His Pro Asp Ala Gln Ala Glu 
            20                  25                  30          


Val Arg Leu Ser Val Pro Pro Leu Val Glu Val Met Arg Gly Lys Ser 
        35                  40                  45              


Val Ile Leu Asp Cys Thr Pro Thr Gly Thr His Asp His Tyr Met Leu 
    50                  55                  60                  


Glu Trp Phe Leu Thr Asp Arg Ser Gly Ala Arg Pro Arg Leu Ala Ser 
65                  70                  75                  80  


Ala Glu Met Gln Gly Ser Glu Leu Gln Val Thr Met His Asp Thr Arg 
                85                  90                  95      


Gly Arg Ser Pro Pro Tyr Gln Leu Asp Ser Gln Gly Arg Leu Val Leu 
            100                 105                 110         


Ala Glu Ala Gln Val Gly Asp Glu Arg Asp Tyr Val Cys Val Val Arg 
        115                 120                 125             


Ala Gly Ala Ala Gly Thr Ala Glu Ala Thr Ala Arg Leu Asn Val Phe 
    130                 135                 140                 


Ala Lys Pro Glu Ala Thr Glu Val Ser Pro Asn Lys Gly Thr Leu Ser 
145                 150                 155                 160 


Val Met Glu Asp Ser Ala Gln Glu Ile Ala Thr Cys Asn Ser Arg Asn 
                165                 170                 175     


Gly Asn Pro Ala Pro Lys Ile Thr Trp Tyr Arg Asn Gly Gln Arg Leu 
            180                 185                 190         


Glu Val Pro Val Glu Met Asn Pro Glu Gly Tyr Met Thr Ser Arg Thr 
        195                 200                 205             


Val Arg Glu Ala Ser Gly Leu Leu Ser Leu Thr Ser Thr Leu Tyr Leu 
    210                 215                 220                 


Arg Leu Arg Lys Asp Asp Arg Asp Ala Ser Phe His Cys Ala Ala His 
225                 230                 235                 240 


Tyr Ser Leu Pro Glu Gly Arg His Gly Arg Leu Asp Ser Pro Thr Phe 
                245                 250                 255     


His Leu Thr Leu His Tyr Pro Thr Glu His Val Gln Phe Trp Val Gly 
            260                 265                 270         


Ser Pro Ser Thr Pro Ala Gly Trp Val Arg Glu Gly Asp Thr Val Gln 
        275                 280                 285             


Leu Leu Cys Arg Gly Asp Gly Ser Pro Ser Pro Glu Tyr Thr Leu Phe 
    290                 295                 300                 


Arg Leu Gln Asp Glu Gln Glu Glu Val Leu Asn Val Asn Leu Glu Gly 
305                 310                 315                 320 


Asn Leu Thr Leu Glu Gly Val Thr Arg Gly Gln Ser Gly Thr Tyr Gly 
                325                 330                 335     


Cys Arg Val Glu Asp Tyr Asp Ala Ala Asp Asp Val Gln Leu Ser Lys 
            340                 345                 350         


Thr Leu Glu Leu Arg Val Ala Tyr Leu Asp Pro Leu Glu Leu Ser Glu 
        355                 360                 365             


Gly Lys Val Leu Ser Leu Pro Leu Asn Ser Ser Ala Val Val Asn Cys 
    370                 375                 380                 


Ser Val His Gly Leu Pro Thr Pro Ala Leu Arg Trp Thr Lys Asp Ser 
385                 390                 395                 400 


Thr Pro Leu Gly Asp Gly Pro Met Leu Ser Leu Ser Ser Ile Thr Phe 
                405                 410                 415     


Asp Ser Asn Gly Thr Tyr Val Cys Glu Ala Ser Leu Pro Thr Val Pro 
            420                 425                 430         


Val Leu Ser Arg Thr Gln Asn Phe Thr Leu Leu Val Gln Gly Ser Pro 
        435                 440                 445             


Glu Leu Lys Thr Ala Glu Ile Glu Pro Lys Ala Asp Gly Ser Trp Arg 
    450                 455                 460                 


Glu Gly Asp Glu Val Thr Leu Ile Cys Ser Ala Arg Gly His Pro Asp 
465                 470                 475                 480 


Pro Lys Leu Ser Trp Ser Gln Leu Gly Gly Ser Pro Ala Glu Pro Ile 
                485                 490                 495     


Pro Gly Arg Gln Gly Trp Val Ser Ser Ser Leu Thr Leu Lys Val Thr 
            500                 505                 510         


Ser Ala Leu Ser Arg Asp Gly Ile Ser Cys Glu Ala Ser Asn Pro His 
        515                 520                 525             


Gly Asn Lys Arg His Val Phe His Phe Gly Thr Val Ser Pro Gln Thr 
    530                 535                 540                 


Ser Gln Ala Gly Val Ala Val Met Ala Val Ala Val Ser Val Gly Leu 
545                 550                 555                 560 


Leu Leu Leu Val Val Ala Val Phe Tyr Cys Val Arg Arg Lys Gly Gly 
                565                 570                 575     


Pro Cys Cys Arg Gln Arg Arg Glu Lys Gly Ala Pro Pro Pro Gly Glu 
            580                 585                 590         


Pro Gly Leu Ser His Ser Gly Ser Glu Gln Pro Glu Gln Thr Gly Leu 
        595                 600                 605             


Leu Met Gly Gly Ala Ser Gly Gly Ala Arg Gly Gly Ser Gly Gly Phe 
    610                 615                 620                 


Gly Asp Glu Cys 
625             


<210>  3318
<211>  661
<212>  PRT
<213>  Homo sapiens

<400>  3318

Met Ala Phe Asp Val Ser Cys Phe Phe Trp Val Val Leu Phe Ser Ala 
1               5                   10                  15      


Gly Cys Lys Val Ile Thr Ser Trp Asp Gln Met Cys Ile Glu Lys Glu 
            20                  25                  30          


Ala Asn Lys Thr Tyr Asn Cys Glu Asn Leu Gly Leu Ser Glu Ile Pro 
        35                  40                  45              


Asp Thr Leu Pro Asn Thr Thr Glu Phe Leu Glu Phe Ser Phe Asn Phe 
    50                  55                  60                  


Leu Pro Thr Ile His Asn Arg Thr Phe Ser Arg Leu Met Asn Leu Thr 
65                  70                  75                  80  


Phe Leu Asp Leu Thr Arg Cys Gln Ile Asn Trp Ile His Glu Asp Thr 
                85                  90                  95      


Phe Gln Ser His His Gln Leu Ser Thr Leu Val Leu Thr Gly Asn Pro 
            100                 105                 110         


Leu Ile Phe Met Ala Glu Thr Ser Leu Asn Gly Pro Lys Ser Leu Lys 
        115                 120                 125             


His Leu Phe Leu Ile Gln Thr Gly Ile Ser Asn Leu Glu Phe Ile Pro 
    130                 135                 140                 


Val His Asn Leu Glu Asn Leu Glu Ser Leu Tyr Leu Gly Ser Asn His 
145                 150                 155                 160 


Ile Ser Ser Ile Lys Phe Pro Lys Asp Phe Pro Ala Arg Asn Leu Lys 
                165                 170                 175     


Val Leu Asp Phe Gln Asn Asn Ala Ile His Tyr Ile Ser Arg Glu Asp 
            180                 185                 190         


Met Arg Ser Leu Glu Gln Ala Ile Asn Leu Ser Leu Asn Phe Asn Gly 
        195                 200                 205             


Asn Asn Val Lys Gly Ile Glu Leu Gly Ala Phe Asp Ser Thr Ile Phe 
    210                 215                 220                 


Gln Ser Leu Asn Phe Gly Gly Thr Pro Asn Leu Ser Val Ile Phe Asn 
225                 230                 235                 240 


Gly Leu Gln Asn Ser Thr Thr Gln Ser Leu Trp Leu Gly Thr Phe Glu 
                245                 250                 255     


Asp Ile Asp Asp Glu Asp Ile Ser Ser Ala Met Leu Lys Gly Leu Cys 
            260                 265                 270         


Glu Met Ser Val Glu Ser Leu Asn Leu Gln Glu His Arg Phe Ser Asp 
        275                 280                 285             


Ile Ser Ser Thr Thr Phe Gln Cys Phe Thr Gln Leu Gln Glu Leu Asp 
    290                 295                 300                 


Leu Thr Ala Thr His Leu Lys Gly Leu Pro Ser Gly Met Lys Gly Leu 
305                 310                 315                 320 


Asn Leu Leu Lys Lys Leu Val Leu Ser Val Asn His Phe Asp Gln Leu 
                325                 330                 335     


Cys Gln Ile Ser Ala Ala Asn Phe Pro Ser Leu Thr His Leu Tyr Ile 
            340                 345                 350         


Arg Gly Asn Val Lys Lys Leu His Leu Gly Val Gly Cys Leu Glu Lys 
        355                 360                 365             


Leu Gly Asn Leu Gln Thr Leu Asp Leu Ser His Asn Asp Ile Glu Ala 
    370                 375                 380                 


Ser Asp Cys Cys Ser Leu Gln Leu Lys Asn Leu Ser His Leu Gln Thr 
385                 390                 395                 400 


Leu Asn Leu Ser His Asn Glu Pro Leu Gly Leu Gln Ser Gln Ala Phe 
                405                 410                 415     


Lys Glu Cys Pro Gln Leu Glu Leu Leu Asp Leu Ala Phe Thr Arg Leu 
            420                 425                 430         


His Ile Asn Ala Pro Gln Ser Pro Phe Gln Asn Leu His Phe Leu Gln 
        435                 440                 445             


Val Leu Asn Leu Thr Tyr Cys Phe Leu Asp Thr Ser Asn Gln His Leu 
    450                 455                 460                 


Leu Ala Gly Leu Pro Val Leu Arg His Leu Asn Leu Lys Gly Asn His 
465                 470                 475                 480 


Phe Gln Asp Gly Thr Ile Thr Lys Thr Asn Leu Leu Gln Thr Val Gly 
                485                 490                 495     


Ser Leu Glu Val Leu Ile Leu Ser Ser Cys Gly Leu Leu Ser Ile Asp 
            500                 505                 510         


Gln Gln Ala Phe His Ser Leu Gly Lys Met Ser His Val Asp Leu Ser 
        515                 520                 525             


His Asn Ser Leu Thr Cys Asp Ser Ile Asp Ser Leu Ser His Leu Lys 
    530                 535                 540                 


Gly Ile Tyr Leu Asn Leu Ala Ala Asn Ser Ile Asn Ile Ile Ser Pro 
545                 550                 555                 560 


Arg Leu Leu Pro Ile Leu Ser Gln Gln Ser Thr Ile Asn Leu Ser His 
                565                 570                 575     


Asn Pro Leu Asp Cys Thr Cys Ser Asn Ile His Phe Leu Thr Trp Tyr 
            580                 585                 590         


Lys Glu Asn Leu His Lys Leu Glu Gly Ser Glu Glu Thr Thr Cys Ala 
        595                 600                 605             


Asn Pro Pro Ser Leu Arg Gly Val Lys Leu Ser Asp Val Lys Leu Ser 
    610                 615                 620                 


Cys Gly Ile Thr Ala Ile Gly Ile Phe Phe Leu Ile Val Phe Leu Leu 
625                 630                 635                 640 


Leu Leu Ala Ile Leu Leu Phe Phe Ala Val Lys Tyr Leu Leu Arg Trp 
                645                 650                 655     


Lys Tyr Gln His Ile 
            660     


<210>  3319
<211>  746
<212>  PRT
<213>  Homo sapiens

<400>  3319

Met Ala Trp Ile Arg Ser Thr Cys Ile Leu Phe Phe Thr Leu Leu Phe 
1               5                   10                  15      


Ala His Ile Ala Ala Val Pro Ile Lys Tyr Leu Pro Glu Glu Asn Val 
            20                  25                  30          


His Asp Ala Asp Phe Gly Glu Gln Lys Asp Ile Ser Glu Ile Asn Leu 
        35                  40                  45              


Ala Ala Gly Leu Asp Leu Phe Gln Gly Asp Ile Leu Leu Gln Lys Ser 
    50                  55                  60                  


Arg Asn Gly Leu Arg Asp Pro Asn Thr Arg Trp Thr Phe Pro Ile Pro 
65                  70                  75                  80  


Tyr Ile Leu Ala Asp Asn Leu Gly Leu Asn Ala Lys Gly Ala Ile Leu 
                85                  90                  95      


Tyr Ala Phe Glu Met Phe Arg Leu Lys Ser Cys Val Asp Phe Lys Pro 
            100                 105                 110         


Tyr Glu Gly Glu Ser Ser Tyr Ile Ile Phe Gln Gln Phe Asp Gly Cys 
        115                 120                 125             


Trp Ser Glu Val Gly Asp Gln His Val Gly Gln Asn Ile Ser Ile Gly 
    130                 135                 140                 


Gln Gly Cys Ala Tyr Lys Ala Ile Ile Glu His Glu Ile Leu His Ala 
145                 150                 155                 160 


Leu Gly Phe Tyr His Glu Gln Ser Arg Thr Asp Arg Asp Asp Tyr Val 
                165                 170                 175     


Asn Ile Trp Trp Asp Gln Ile Leu Ser Gly Tyr Gln His Asn Phe Asp 
            180                 185                 190         


Thr Tyr Asp Asp Ser Leu Ile Thr Asp Leu Asn Thr Pro Tyr Asp Tyr 
        195                 200                 205             


Glu Ser Leu Met His Tyr Gln Pro Phe Ser Phe Asn Lys Asn Ala Ser 
    210                 215                 220                 


Val Pro Thr Ile Thr Ala Lys Ile Pro Glu Phe Asn Ser Ile Ile Gly 
225                 230                 235                 240 


Gln Arg Leu Asp Phe Ser Ala Ile Asp Leu Glu Arg Leu Asn Arg Met 
                245                 250                 255     


Tyr Asn Cys Thr Thr Thr His Thr Leu Leu Asp His Cys Thr Phe Glu 
            260                 265                 270         


Lys Ala Asn Ile Cys Gly Met Ile Gln Gly Thr Arg Asp Asp Thr Asp 
        275                 280                 285             


Trp Ala His Gln Asp Ser Ala Gln Ala Gly Glu Val Asp His Thr Leu 
    290                 295                 300                 


Leu Gly Gln Cys Thr Gly Ala Gly Tyr Phe Met Gln Phe Ser Thr Ser 
305                 310                 315                 320 


Ser Gly Ser Ala Glu Glu Ala Ala Leu Leu Glu Ser Arg Ile Leu Tyr 
                325                 330                 335     


Pro Lys Arg Lys Gln Gln Cys Leu Gln Phe Phe Tyr Lys Met Thr Gly 
            340                 345                 350         


Ser Pro Ser Asp Arg Leu Val Val Trp Val Arg Arg Asp Asp Ser Thr 
        355                 360                 365             


Gly Asn Val Arg Lys Leu Val Lys Val Gln Thr Phe Gln Gly Asp Asp 
    370                 375                 380                 


Asp His Asn Trp Lys Ile Ala His Val Val Leu Lys Glu Glu Gln Lys 
385                 390                 395                 400 


Phe Arg Tyr Leu Phe Gln Gly Thr Lys Gly Asp Pro Gln Asn Ser Thr 
                405                 410                 415     


Gly Gly Ile Tyr Leu Asp Asp Ile Thr Leu Thr Glu Thr Pro Cys Pro 
            420                 425                 430         


Thr Gly Val Trp Thr Val Arg Asn Phe Ser Gln Val Leu Glu Asn Thr 
        435                 440                 445             


Ser Lys Gly Asp Lys Leu Gln Ser Pro Arg Phe Tyr Asn Ser Glu Gly 
    450                 455                 460                 


Tyr Gly Phe Gly Val Thr Leu Tyr Pro Asn Ser Arg Glu Ser Ser Gly 
465                 470                 475                 480 


Tyr Leu Arg Leu Ala Phe His Val Cys Ser Gly Glu Asn Asp Ala Ile 
                485                 490                 495     


Leu Glu Trp Pro Val Glu Asn Arg Gln Val Ile Ile Thr Ile Leu Asp 
            500                 505                 510         


Gln Glu Pro Asp Val Arg Asn Arg Met Ser Ser Ser Met Val Phe Thr 
        515                 520                 525             


Thr Ser Lys Ser His Thr Ser Pro Ala Ile Asn Asp Thr Val Ile Trp 
    530                 535                 540                 


Asp Arg Pro Ser Arg Val Gly Thr Tyr His Thr Asp Cys Asn Cys Phe 
545                 550                 555                 560 


Arg Ser Ile Asp Leu Gly Trp Ser Gly Phe Ile Ser His Gln Met Leu 
                565                 570                 575     


Lys Arg Arg Ser Phe Leu Lys Asn Asp Asp Leu Ile Ile Phe Val Asp 
            580                 585                 590         


Phe Glu Asp Ile Thr His Leu Ser Gln Thr Glu Val Pro Thr Lys Gly 
        595                 600                 605             


Lys Arg Leu Ser Pro Gln Gly Leu Ile Leu Gln Gly Gln Glu Gln Gln 
    610                 615                 620                 


Val Ser Glu Glu Gly Ser Gly Lys Ala Met Leu Glu Glu Ala Leu Pro 
625                 630                 635                 640 


Val Ser Leu Ser Gln Gly Gln Pro Ser Arg Gln Lys Arg Ser Val Glu 
                645                 650                 655     


Asn Thr Gly Pro Leu Glu Asp His Asn Trp Pro Gln Tyr Phe Arg Asp 
            660                 665                 670         


Pro Cys Asp Pro Asn Pro Cys Gln Asn Asp Gly Ile Cys Val Asn Val 
        675                 680                 685             


Lys Gly Met Ala Ser Cys Arg Cys Ile Ser Gly His Ala Phe Phe Tyr 
    690                 695                 700                 


Thr Gly Glu Arg Cys Gln Ala Val Gln Val His Gly Ser Val Leu Gly 
705                 710                 715                 720 


Met Val Ile Gly Gly Thr Ala Gly Val Ile Phe Leu Thr Phe Ser Ile 
                725                 730                 735     


Ile Ala Ile Leu Ser Gln Arg Pro Arg Lys 
            740                 745     


<210>  3320
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  3320

Met Ile Thr Cys His Asn Asp Arg Ile Ala Leu Ile Ser Phe Arg Met 
1               5                   10                  15      


Pro Arg Glu Cys Arg Ser Arg His Met Ser Ala Pro Ile Glu Asn Ser 
            20                  25                  30          


<210>  3321
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  3321

Met Glu Leu Cys Arg Ser Leu Ala Leu Leu Gly Gly Ser Leu Gly Leu 
1               5                   10                  15      


Met Phe Cys Leu Ile Ala Leu Ser Thr Asp Phe Trp Phe Glu Ala Val 
            20                  25                  30          


Gly Pro Thr His Ser Ala His Ser Gly Leu Trp Pro Thr Gly His Gly 
        35                  40                  45              


Asp Ile Ile Ser Gly Tyr Ile His Val Thr Gln Thr Phe Ser Ile Met 
    50                  55                  60                  


Ala Val Leu Trp Ala Leu Val Ser Val Ser Phe Leu Val Leu Ser Cys 
65                  70                  75                  80  


Phe Pro Ser Leu Phe Pro Pro Gly His Gly Pro Leu Val Ser Thr Thr 
                85                  90                  95      


Ala Ala Phe Ala Ala Ala Ile Ser Met Val Val Ala Met Ala Val Tyr 
            100                 105                 110         


Thr Ser Glu Arg Trp Asp Gln Pro Pro His Pro Gln Ile Gln Thr Phe 
        115                 120                 125             


Phe Ser Trp Ser Phe Tyr Leu Gly Trp Val Ser Ala Ile Leu Leu Leu 
    130                 135                 140                 


Cys Thr Gly Ala Leu Ser Leu Gly Ala His Cys Gly Gly Pro Arg Pro 
145                 150                 155                 160 


Gly Tyr Glu Thr Leu 
                165 


<210>  3322
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  3322

Met Val Ala Thr Cys Leu Gln Val Val Gly Phe Val Thr Ser Phe Val 
1               5                   10                  15      


Gly Trp Ile Gly Val Ile Val Thr Thr Ser Thr Asn Asp Trp Val Val 
            20                  25                  30          


Thr Cys Gly Tyr Thr Ile Pro Thr Cys Arg Lys Leu Asp Glu Leu Gly 
        35                  40                  45              


Ser Lys Gly Leu Trp Ala Asp Cys Val Met Ala Thr Gly Leu Tyr His 
    50                  55                  60                  


Cys Lys Pro Leu Val Asp Ile Leu Ile Leu Pro Gly Tyr Val Gln Ala 
65                  70                  75                  80  


Cys Arg Ala Leu Met Ile Ala Ala Ser Val Leu Gly Leu Pro Ala Ile 
                85                  90                  95      


Leu Leu Leu Leu Thr Val Leu Pro Cys Ile Arg Met Gly Gln Glu Pro 
            100                 105                 110         


Gly Val Ala Lys Tyr Arg Arg Ala Gln Leu Ala Gly Val Leu Leu Ile 
        115                 120                 125             


Leu Leu Ala Leu Cys Ala Leu Val Ala Thr Ile Trp Phe Pro Val Cys 
    130                 135                 140                 


Ala His Arg Glu Thr Thr Ile Val Ser Phe Gly Tyr Ser Leu Tyr Ala 
145                 150                 155                 160 


Gly Trp Ile Gly Ala Val Leu Cys Leu Val Gly Gly Cys Val Ile Leu 
                165                 170                 175     


Cys Cys Ala Gly Asp Ala Gln Ala Phe Gly Glu Asn Arg Phe Tyr Tyr 
            180                 185                 190         


Thr Ala Gly Ser Ser Ser Pro Thr His Ala Lys Ser Ala His Val 
        195                 200                 205         


<210>  3323
<211>  1251
<212>  PRT
<213>  Homo sapiens

<400>  3323

Met Ser Thr Glu Arg Asp Ser Glu Thr Thr Phe Asp Glu Asp Ser Gln 
1               5                   10                  15      


Pro Asn Asp Glu Val Val Pro Tyr Ser Asp Asp Glu Thr Glu Asp Glu 
            20                  25                  30          


Leu Asp Asp Gln Gly Ser Ala Val Glu Pro Glu Gln Asn Arg Val Asn 
        35                  40                  45              


Arg Glu Ala Glu Glu Asn Arg Glu Pro Phe Arg Lys Glu Cys Thr Trp 
    50                  55                  60                  


Gln Val Lys Ala Asn Asp Arg Lys Tyr His Glu Gln Pro His Phe Met 
65                  70                  75                  80  


Asn Thr Lys Phe Leu Cys Ile Lys Glu Ser Lys Tyr Ala Asn Asn Ala 
                85                  90                  95      


Ile Lys Thr Tyr Lys Tyr Asn Ala Phe Thr Phe Ile Pro Met Asn Leu 
            100                 105                 110         


Phe Glu Gln Phe Lys Arg Ala Ala Asn Leu Tyr Phe Leu Ala Leu Leu 
        115                 120                 125             


Ile Leu Gln Ala Val Pro Gln Ile Ser Thr Leu Ala Trp Tyr Thr Thr 
    130                 135                 140                 


Leu Val Pro Leu Leu Val Val Leu Gly Val Thr Ala Ile Lys Asp Leu 
145                 150                 155                 160 


Val Asp Asp Val Ala Arg His Lys Met Asp Lys Glu Ile Asn Asn Arg 
                165                 170                 175     


Thr Cys Glu Val Ile Lys Asp Gly Arg Phe Lys Val Ala Lys Trp Lys 
            180                 185                 190         


Glu Ile Gln Val Gly Asp Val Ile Arg Leu Lys Lys Asn Asp Phe Val 
        195                 200                 205             


Pro Ala Asp Ile Leu Leu Leu Ser Ser Ser Glu Pro Asn Ser Leu Cys 
    210                 215                 220                 


Tyr Val Glu Thr Ala Glu Leu Asp Gly Glu Thr Asn Leu Lys Phe Lys 
225                 230                 235                 240 


Met Ser Leu Glu Ile Thr Asp Gln Tyr Leu Gln Arg Glu Asp Thr Leu 
                245                 250                 255     


Ala Thr Phe Asp Gly Phe Ile Glu Cys Glu Glu Pro Asn Asn Arg Leu 
            260                 265                 270         


Asp Lys Phe Thr Gly Thr Leu Phe Trp Arg Asn Thr Ser Phe Pro Leu 
        275                 280                 285             


Asp Ala Asp Lys Ile Leu Leu Arg Gly Cys Val Ile Arg Asn Thr Asp 
    290                 295                 300                 


Phe Cys His Gly Leu Val Ile Phe Ala Gly Ala Asp Thr Lys Ile Met 
305                 310                 315                 320 


Lys Asn Ser Gly Lys Thr Arg Phe Lys Arg Thr Lys Ile Asp Tyr Leu 
                325                 330                 335     


Met Asn Tyr Met Val Tyr Thr Ile Phe Val Val Leu Ile Leu Leu Ser 
            340                 345                 350         


Ala Gly Leu Ala Ile Gly His Ala Tyr Trp Glu Ala Gln Val Gly Asn 
        355                 360                 365             


Ser Ser Trp Tyr Leu Tyr Asp Gly Glu Asp Asp Thr Pro Ser Tyr Arg 
    370                 375                 380                 


Gly Phe Leu Ile Phe Trp Gly Tyr Ile Ile Val Leu Asn Thr Met Val 
385                 390                 395                 400 


Pro Ile Ser Leu Tyr Val Ser Val Glu Val Ile Arg Leu Gly Gln Ser 
                405                 410                 415     


His Phe Ile Asn Trp Asp Leu Gln Met Tyr Tyr Ala Glu Lys Asp Thr 
            420                 425                 430         


Pro Ala Lys Ala Arg Thr Thr Thr Leu Asn Glu Gln Leu Gly Gln Ile 
        435                 440                 445             


His Tyr Ile Phe Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn Ile Met 
    450                 455                 460                 


Thr Phe Lys Lys Cys Cys Ile Asn Gly Gln Ile Tyr Gly Asp His Arg 
465                 470                 475                 480 


Asp Ala Ser Gln His Asn His Asn Lys Ile Glu Gln Val Asp Phe Ser 
                485                 490                 495     


Trp Asn Thr Tyr Ala Asp Gly Lys Leu Ala Phe Tyr Asp His Tyr Leu 
            500                 505                 510         


Ile Glu Gln Ile Gln Ser Gly Lys Glu Pro Glu Val Arg Gln Phe Phe 
        515                 520                 525             


Phe Leu Leu Ala Val Cys His Thr Val Met Val Asp Arg Thr Asp Gly 
    530                 535                 540                 


Gln Leu Asn Tyr Gln Ala Ala Ser Pro Asp Glu Gly Ala Leu Val Asn 
545                 550                 555                 560 


Ala Ala Arg Asn Phe Gly Phe Ala Phe Leu Ala Arg Thr Gln Asn Thr 
                565                 570                 575     


Ile Thr Ile Ser Glu Leu Gly Thr Glu Arg Thr Tyr Asn Val Leu Ala 
            580                 585                 590         


Ile Leu Asp Phe Asn Ser Asp Arg Lys Arg Met Ser Ile Ile Val Arg 
        595                 600                 605             


Thr Pro Glu Gly Asn Ile Lys Leu Tyr Cys Lys Gly Ala Asp Thr Val 
    610                 615                 620                 


Ile Tyr Glu Arg Leu His Arg Met Asn Pro Thr Lys Gln Glu Thr Gln 
625                 630                 635                 640 


Asp Ala Leu Asp Ile Phe Ala Asn Glu Thr Leu Arg Thr Leu Cys Leu 
                645                 650                 655     


Cys Tyr Lys Glu Ile Glu Glu Lys Glu Phe Thr Glu Trp Asn Lys Lys 
            660                 665                 670         


Phe Met Ala Ala Ser Val Ala Ser Thr Asn Arg Asp Glu Ala Leu Asp 
        675                 680                 685             


Lys Val Tyr Glu Glu Ile Glu Lys Asp Leu Ile Leu Leu Gly Ala Thr 
    690                 695                 700                 


Ala Ile Glu Asp Lys Leu Gln Asp Gly Val Pro Glu Thr Ile Ser Lys 
705                 710                 715                 720 


Leu Ala Lys Ala Asp Ile Lys Ile Trp Val Leu Thr Gly Asp Lys Lys 
                725                 730                 735     


Glu Thr Ala Glu Asn Ile Gly Phe Ala Cys Glu Leu Leu Thr Glu Asp 
            740                 745                 750         


Thr Thr Ile Cys Tyr Gly Glu Asp Ile Asn Ser Leu Leu His Ala Arg 
        755                 760                 765             


Met Glu Asn Gln Arg Asn Arg Gly Gly Val Tyr Ala Lys Phe Ala Pro 
    770                 775                 780                 


Pro Val Gln Glu Ser Phe Phe Pro Pro Gly Gly Asn Arg Ala Leu Ile 
785                 790                 795                 800 


Ile Thr Gly Ser Trp Leu Asn Glu Ile Leu Leu Glu Lys Lys Thr Lys 
                805                 810                 815     


Arg Asn Lys Ile Leu Lys Leu Lys Phe Pro Arg Thr Glu Glu Glu Arg 
            820                 825                 830         


Arg Met Arg Thr Gln Ser Lys Arg Arg Leu Glu Ala Lys Lys Glu Gln 
        835                 840                 845             


Arg Gln Lys Asn Phe Val Asp Leu Ala Cys Glu Cys Ser Ala Val Ile 
    850                 855                 860                 


Cys Cys Arg Val Thr Pro Lys Gln Lys Ala Met Val Val Asp Leu Val 
865                 870                 875                 880 


Lys Arg Tyr Lys Lys Ala Ile Thr Leu Ala Ile Gly Asp Gly Ala Asn 
                885                 890                 895     


Asp Val Asn Met Ile Lys Thr Ala His Ile Gly Val Gly Ile Ser Gly 
            900                 905                 910         


Gln Glu Gly Met Gln Ala Val Met Ser Ser Asp Tyr Ser Phe Ala Gln 
        915                 920                 925             


Phe Arg Tyr Leu Gln Arg Leu Leu Leu Val His Gly Arg Trp Ser Tyr 
    930                 935                 940                 


Ile Arg Met Cys Lys Phe Leu Arg Tyr Phe Phe Tyr Lys Asn Phe Ala 
945                 950                 955                 960 


Phe Thr Leu Val His Phe Trp Tyr Ser Phe Phe Asn Gly Tyr Ser Ala 
                965                 970                 975     


Gln Thr Ala Tyr Glu Asp Trp Phe Ile Thr Leu Tyr Asn Val Leu Tyr 
            980                 985                 990         


Thr Ser Leu Pro Val Leu Leu Met  Gly Leu Leu Asp Gln  Asp Val Ser 
        995                 1000                 1005             


Asp Lys  Leu Ser Leu Arg Phe  Pro Gly Leu Tyr Ile  Val Gly Gln 
    1010                 1015                 1020             


Arg Asp  Leu Leu Phe Asn Tyr  Lys Arg Phe Phe Val  Ser Leu Leu 
    1025                 1030                 1035             


His Gly  Val Leu Thr Ser Met  Ile Leu Phe Phe Ile  Pro Leu Gly 
    1040                 1045                 1050             


Ala Tyr  Leu Gln Thr Val Gly  Gln Asp Gly Glu Ala  Pro Ser Asp 
    1055                 1060                 1065             


Tyr Gln  Ser Phe Ala Val Thr  Ile Ala Ser Ala Leu  Val Ile Thr 
    1070                 1075                 1080             


Val Asn  Phe Gln Ile Gly Leu  Asp Thr Ser Tyr Trp  Thr Phe Val 
    1085                 1090                 1095             


Asn Ala  Phe Ser Ile Phe Gly  Ser Ile Ala Leu Tyr  Phe Gly Ile 
    1100                 1105                 1110             


Met Phe  Asp Phe His Ser Ala  Gly Ile His Val Leu  Phe Pro Ser 
    1115                 1120                 1125             


Ala Phe  Gln Phe Thr Gly Thr  Ala Ser Asn Ala Leu  Arg Gln Pro 
    1130                 1135                 1140             


Tyr Ile  Trp Leu Thr Ile Ile  Leu Thr Val Ala Val  Cys Leu Leu 
    1145                 1150                 1155             


Pro Val  Val Ala Ile Arg Phe  Leu Ser Met Thr Ile  Trp Pro Ser 
    1160                 1165                 1170             


Glu Ser  Asp Lys Ile Gln Lys  His Arg Lys Arg Leu  Lys Ala Glu 
    1175                 1180                 1185             


Glu Gln  Trp Gln Arg Arg Gln  Gln Val Phe Arg Arg  Gly Val Ser 
    1190                 1195                 1200             


Thr Arg  Arg Ser Ala Tyr Ala  Phe Ser His Gln Arg  Gly Tyr Ala 
    1205                 1210                 1215             


Asp Leu  Ile Ser Ser Gly Arg  Ser Ile Arg Lys Lys  Arg Ser Pro 
    1220                 1225                 1230             


Leu Asp  Ala Ile Val Ala Asp  Gly Thr Ala Glu Tyr  Arg Arg Thr 
    1235                 1240                 1245             


Gly Asp  Ser 
    1250     


<210>  3324
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  3324

Met Ala Leu Pro Cys Thr Leu Gly Leu Gly Met Leu Leu Ala Leu Pro 
1               5                   10                  15      


Gly Ala Leu Gly Ser Gly Gly Ser Ala Glu Asp Ser Val Gly Ser Ser 
            20                  25                  30          


Ser Val Thr Val Val Leu Leu Leu Leu Leu Leu Leu Leu Leu Ala Thr 
        35                  40                  45              


Gly Leu Ala Leu Ala Trp Arg Arg Leu Ser Arg Asp Ser Gly Gly Tyr 
    50                  55                  60                  


Tyr His Pro Ala Arg Leu Gly Ala Ala Leu Trp Gly Arg Thr Arg Arg 
65                  70                  75                  80  


Leu Leu Trp Ala Ser Pro Pro Gly Arg Trp Leu Gln Ala Arg Ala Glu 
                85                  90                  95      


Leu Gly Ser Thr Asp Asn Asp Leu Glu Arg Gln Glu Asp Glu Gln Asp 
            100                 105                 110         


Thr Asp Tyr Asp His Val Ala Asp Gly Gly Leu Gln Ala Asp Pro Gly 
        115                 120                 125             


Glu Gly Glu Gln Gln Cys Gly Glu Ala Ser Ser Pro Glu Gln Val Pro 
    130                 135                 140                 


Val Arg Ala Glu Glu Ala Arg Asp Ser Asp Thr Glu Gly Asp Leu Val 
145                 150                 155                 160 


Leu Gly Ser Pro Gly Pro Ala Ser Ala Gly Gly Ser Ala Glu Ala Leu 
                165                 170                 175     


Leu Ser Asp Leu His Ala Phe Ala Gly Ser Ala Ala Trp Asp Asp Ser 
            180                 185                 190         


Ala Arg Ala Ala Gly Gly Gln Gly Leu His Val Thr Ala Leu 
        195                 200                 205     


<210>  3325
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  3325

Met Val Leu Cys Phe Pro Leu Leu Leu Leu Leu Leu Val Leu Trp Gly 
1               5                   10                  15      


Pro Val Cys Pro Leu His Ala Trp Pro Lys Arg Leu Thr Lys Ala His 
            20                  25                  30          


Trp Phe Glu Ile Gln His Ile Gln Pro Ser Pro Leu Gln Cys Asn Arg 
        35                  40                  45              


Ala Met Ser Gly Ile Asn Asn Tyr Thr Gln His Cys Lys His Gln Asn 
    50                  55                  60                  


Thr Phe Leu His Asp Ser Phe Gln Asn Val Ala Ala Val Cys Asp Leu 
65                  70                  75                  80  


Leu Ser Ile Val Cys Lys Asn Arg Arg His Asn Cys His Gln Ser Ser 
                85                  90                  95      


Lys Pro Val Asn Met Thr Asp Cys Arg Leu Thr Ser Gly Lys Tyr Pro 
            100                 105                 110         


Gln Cys Arg Tyr Ser Ala Ala Ala Gln Tyr Lys Phe Phe Ile Val Ala 
        115                 120                 125             


Cys Asp Pro Pro Gln Lys Ser Asp Pro Pro Tyr Lys Leu Val Pro Val 
    130                 135                 140                 


His Leu Asp Ser Ile Leu 
145                 150 


<210>  3326
<211>  723
<212>  PRT
<213>  Homo sapiens

<400>  3326

Met Gly Ser Arg Cys Ala Leu Ala Leu Ala Val Leu Ser Ala Leu Leu 
1               5                   10                  15      


Cys Gln Val Trp Ser Ser Gly Val Phe Glu Leu Lys Leu Gln Glu Phe 
            20                  25                  30          


Val Asn Lys Lys Gly Leu Leu Gly Asn Arg Asn Cys Cys Arg Gly Gly 
        35                  40                  45              


Ala Gly Pro Pro Pro Cys Ala Cys Arg Thr Phe Phe Arg Val Cys Leu 
    50                  55                  60                  


Lys His Tyr Gln Ala Ser Val Ser Pro Glu Pro Pro Cys Thr Tyr Gly 
65                  70                  75                  80  


Ser Ala Val Thr Pro Val Leu Gly Val Asp Ser Phe Ser Leu Pro Asp 
                85                  90                  95      


Gly Gly Gly Ala Asp Ser Ala Phe Ser Asn Pro Ile Arg Phe Pro Phe 
            100                 105                 110         


Gly Phe Thr Trp Pro Gly Thr Phe Ser Leu Ile Ile Glu Ala Leu His 
        115                 120                 125             


Thr Asp Ser Pro Asp Asp Leu Ala Thr Glu Asn Pro Glu Arg Leu Ile 
    130                 135                 140                 


Ser Arg Leu Ala Thr Gln Arg His Leu Thr Val Gly Glu Glu Trp Ser 
145                 150                 155                 160 


Gln Asp Leu His Ser Ser Gly Arg Thr Asp Leu Lys Tyr Ser Tyr Arg 
                165                 170                 175     


Phe Val Cys Asp Glu His Tyr Tyr Gly Glu Gly Cys Ser Val Phe Cys 
            180                 185                 190         


Arg Pro Arg Asp Asp Ala Phe Gly His Phe Thr Cys Gly Glu Arg Gly 
        195                 200                 205             


Glu Lys Val Cys Asn Pro Gly Trp Lys Gly Pro Tyr Cys Thr Glu Pro 
    210                 215                 220                 


Ile Cys Leu Pro Gly Cys Asp Glu Gln His Gly Phe Cys Asp Lys Pro 
225                 230                 235                 240 


Gly Glu Cys Lys Cys Arg Val Gly Trp Gln Gly Arg Tyr Cys Asp Glu 
                245                 250                 255     


Cys Ile Arg Tyr Pro Gly Cys Leu His Gly Thr Cys Gln Gln Pro Trp 
            260                 265                 270         


Gln Cys Asn Cys Gln Glu Gly Trp Gly Gly Leu Phe Cys Asn Gln Asp 
        275                 280                 285             


Leu Asn Tyr Cys Thr His His Lys Pro Cys Lys Asn Gly Ala Thr Cys 
    290                 295                 300                 


Thr Asn Thr Gly Gln Gly Ser Tyr Thr Cys Ser Cys Arg Pro Gly Tyr 
305                 310                 315                 320 


Thr Gly Ala Thr Cys Glu Leu Gly Ile Asp Glu Cys Asp Pro Ser Pro 
                325                 330                 335     


Cys Lys Asn Gly Gly Ser Cys Thr Asp Leu Glu Asn Ser Tyr Ser Cys 
            340                 345                 350         


Thr Cys Pro Pro Gly Phe Tyr Gly Lys Ile Cys Glu Leu Ser Ala Met 
        355                 360                 365             


Thr Cys Ala Asp Gly Pro Cys Phe Asn Gly Gly Arg Cys Ser Asp Ser 
    370                 375                 380                 


Pro Asp Gly Gly Tyr Ser Cys Arg Cys Pro Val Gly Tyr Ser Gly Phe 
385                 390                 395                 400 


Asn Cys Glu Lys Lys Ile Asp Tyr Cys Ser Ser Ser Pro Cys Ser Asn 
                405                 410                 415     


Gly Ala Lys Cys Val Asp Leu Gly Asp Ala Tyr Leu Cys Arg Cys Gln 
            420                 425                 430         


Ala Gly Phe Ser Gly Arg His Cys Asp Asp Asn Val Asp Asp Cys Ala 
        435                 440                 445             


Ser Ser Pro Cys Ala Asn Gly Gly Thr Cys Arg Asp Gly Val Asn Asp 
    450                 455                 460                 


Phe Ser Cys Thr Cys Pro Pro Gly Tyr Thr Gly Arg Asn Cys Ser Ala 
465                 470                 475                 480 


Pro Val Ser Arg Cys Glu His Ala Pro Cys His Asn Gly Ala Thr Cys 
                485                 490                 495     


His Glu Arg Gly His Arg Tyr Val Cys Glu Cys Ala Arg Gly Tyr Gly 
            500                 505                 510         


Gly Pro Asn Cys Gln Phe Leu Leu Pro Glu Leu Pro Pro Gly Pro Ala 
        515                 520                 525             


Val Val Asp Leu Thr Glu Lys Leu Glu Gly Gln Gly Gly Pro Phe Pro 
    530                 535                 540                 


Trp Val Ala Val Cys Ala Gly Val Ile Leu Val Leu Met Leu Leu Leu 
545                 550                 555                 560 


Gly Cys Ala Ala Val Val Val Cys Val Arg Leu Arg Leu Gln Lys His 
                565                 570                 575     


Arg Pro Pro Ala Asp Pro Cys Arg Gly Glu Thr Glu Thr Met Asn Asn 
            580                 585                 590         


Leu Ala Asn Cys Gln Arg Glu Lys Asp Ile Ser Val Ser Ile Ile Gly 
        595                 600                 605             


Ala Thr Gln Ile Lys Asn Thr Asn Lys Lys Ala Asp Phe His Gly Asp 
    610                 615                 620                 


His Ser Ala Asp Lys Asn Gly Phe Lys Ala Arg Tyr Pro Ala Val Asp 
625                 630                 635                 640 


Tyr Asn Leu Val Gln Asp Leu Lys Gly Asp Asp Thr Ala Val Arg Asp 
                645                 650                 655     


Ala His Ser Lys Arg Asp Thr Lys Cys Gln Pro Gln Gly Ser Ser Gly 
            660                 665                 670         


Glu Glu Lys Gly Thr Pro Thr Thr Leu Arg Gly Gly Glu Ala Ser Glu 
        675                 680                 685             


Arg Lys Arg Pro Asp Ser Gly Cys Ser Thr Ser Lys Asp Thr Lys Tyr 
    690                 695                 700                 


Gln Ser Val Tyr Val Ile Ser Glu Glu Lys Asp Glu Cys Val Ile Ala 
705                 710                 715                 720 


Thr Glu Val 
            


<210>  3327
<211>  545
<212>  PRT
<213>  Homo sapiens

<400>  3327

Met Gly Gln Val Leu Pro Val Phe Ala His Cys Lys Glu Ala Pro Ser 
1               5                   10                  15      


Thr Ala Ser Ser Thr Pro Asp Ser Thr Glu Gly Gly Asn Asp Asp Ser 
            20                  25                  30          


Asp Phe Arg Glu Leu His Thr Ala Arg Glu Phe Ser Glu Glu Asp Glu 
        35                  40                  45              


Glu Glu Thr Thr Ser Gln Asp Trp Gly Thr Pro Arg Glu Leu Thr Phe 
    50                  55                  60                  


Ser Tyr Ile Ala Phe Asp Gly Val Val Gly Ser Gly Gly Arg Arg Asp 
65                  70                  75                  80  


Ser Thr Ala Arg Arg Pro Arg Pro Gln Gly Arg Ser Val Ser Glu Pro 
                85                  90                  95      


Arg Asp Gln His Pro Gln Pro Ser Leu Gly Asp Ser Leu Glu Ser Ile 
            100                 105                 110         


Pro Ser Leu Ser Gln Ser Pro Glu Pro Gly Arg Arg Gly Asp Pro Asp 
        115                 120                 125             


Thr Ala Pro Pro Ser Glu Arg Pro Leu Glu Asp Leu Arg Leu Arg Leu 
    130                 135                 140                 


Asp His Leu Gly Trp Val Ala Arg Gly Thr Gly Ser Gly Glu Asp Ser 
145                 150                 155                 160 


Ser Thr Ser Ser Ser Thr Pro Leu Glu Asp Glu Glu Pro Gln Glu Pro 
                165                 170                 175     


Asn Arg Leu Glu Thr Gly Glu Ala Gly Glu Glu Leu Asp Leu Arg Leu 
            180                 185                 190         


Arg Leu Ala Gln Pro Ser Ser Pro Glu Val Leu Thr Pro Gln Leu Ser 
        195                 200                 205             


Pro Gly Ser Gly Thr Pro Gln Ala Gly Thr Pro Ser Pro Ser Arg Ser 
    210                 215                 220                 


Arg Asp Ser Asn Ser Gly Pro Glu Glu Pro Leu Leu Glu Glu Glu Glu 
225                 230                 235                 240 


Lys Gln Trp Gly Pro Leu Glu Arg Glu Pro Val Arg Gly Gln Cys Leu 
                245                 250                 255     


Asp Ser Thr Asp Gln Leu Glu Phe Thr Val Glu Pro Arg Leu Leu Gly 
            260                 265                 270         


Thr Ala Met Glu Trp Leu Lys Thr Ser Leu Leu Leu Ala Val Tyr Lys 
        275                 280                 285             


Thr Val Pro Ile Leu Glu Leu Ser Pro Pro Leu Trp Thr Ala Ile Gly 
    290                 295                 300                 


Trp Val Gln Arg Gly Pro Thr Pro Pro Thr Pro Val Leu Arg Val Leu 
305                 310                 315                 320 


Leu Lys Trp Ala Lys Ser Pro Arg Ser Ser Gly Val Pro Ser Leu Ser 
                325                 330                 335     


Leu Gly Ala Asp Met Gly Ser Lys Val Ala Asp Leu Leu Tyr Trp Lys 
            340                 345                 350         


Asp Thr Arg Thr Ser Gly Val Val Phe Thr Gly Leu Met Val Ser Leu 
        355                 360                 365             


Leu Cys Leu Leu His Phe Ser Ile Val Ser Val Ala Ala His Leu Ala 
    370                 375                 380                 


Leu Leu Leu Leu Cys Gly Thr Ile Ser Leu Arg Val Tyr Arg Lys Val 
385                 390                 395                 400 


Leu Gln Ala Val His Arg Gly Asp Gly Ala Asn Pro Phe Gln Ala Tyr 
                405                 410                 415     


Leu Asp Val Asp Leu Thr Leu Thr Arg Glu Gln Thr Glu Arg Leu Ser 
            420                 425                 430         


His Gln Ile Thr Ser Arg Val Val Ser Ala Ala Thr Gln Leu Arg His 
        435                 440                 445             


Phe Phe Leu Val Glu Asp Leu Val Asp Ser Leu Lys Leu Ala Leu Leu 
    450                 455                 460                 


Phe Tyr Ile Leu Thr Phe Val Gly Ala Ile Phe Asn Gly Leu Thr Leu 
465                 470                 475                 480 


Leu Ile Leu Gly Val Ile Gly Leu Phe Thr Ile Pro Leu Leu Tyr Arg 
                485                 490                 495     


Gln His Gln Ala Gln Ile Asp Gln Tyr Val Gly Leu Val Thr Asn Gln 
            500                 505                 510         


Leu Ser His Ile Lys Ala Lys Ile Arg Ala Lys Ile Pro Gly Thr Gly 
        515                 520                 525             


Ala Leu Ala Ser Ala Ala Ala Ala Val Ser Gly Ser Lys Ala Lys Ala 
    530                 535                 540                 


Glu 
545 


<210>  3328
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  3328

Met Ser Leu Tyr Pro Ser Leu Glu Asp Leu Lys Val Asp Lys Val Ile 
1               5                   10                  15      


Gln Ala Gln Thr Ala Phe Ser Ala Asn Pro Ala Asn Pro Ala Ile Leu 
            20                  25                  30          


Ser Glu Ala Ser Ala Pro Ile Pro His Asp Gly Asn Leu Tyr Pro Arg 
        35                  40                  45              


Leu Tyr Pro Glu Leu Ser Gln Tyr Met Gly Leu Ser Leu Asn Glu Glu 
    50                  55                  60                  


Glu Ile Arg Ala Asn Val Ala Val Val Ser Gly Ala Pro Leu Gln Gly 
65                  70                  75                  80  


Gln Leu Val Ala Arg Pro Ser Ser Ile Asn Tyr Met Val Ala Pro Val 
                85                  90                  95      


Thr Gly Asn Asp Val Gly Ile Arg Arg Ala Glu Ile Lys Gln Gly Ile 
            100                 105                 110         


Arg Glu Val Ile Leu Cys Lys Asp Gln Asp Gly Lys Ile Gly Leu Arg 
        115                 120                 125             


Leu Lys Ser Ile Asp Asn Gly Ile Phe Val Gln Leu Val Gln Ala Asn 
    130                 135                 140                 


Ser Pro Ala Ser Leu Val Gly Leu Arg Phe Gly Asp Gln Val Leu Gln 
145                 150                 155                 160 


Ile Asn Gly Glu Asn Cys Ala Gly Trp Ser Ser Asp Lys Ala His Lys 
                165                 170                 175     


Val Leu Lys Gln Ala Phe Gly Glu Lys Ile Thr Met Thr Ile Arg Asp 
            180                 185                 190         


Arg Pro Phe Glu Arg Thr Ile Thr Met His Lys Asp Ser Thr Gly His 
        195                 200                 205             


Val Gly Phe Ile Phe Lys Asn Gly Lys Ile Thr Ser Ile Val Lys Asp 
    210                 215                 220                 


Ser Ser Ala Ala Arg Asn Gly Leu Leu Thr Glu His Asn Ile Cys Glu 
225                 230                 235                 240 


Ile Asn Gly Gln Asn Val Ile Gly Leu Lys Asp Ser Gln Ile Ala Asp 
                245                 250                 255     


Ile Leu Ser Thr Ser Gly Thr Val Val Thr Ile Thr Ile Met Pro Ala 
            260                 265                 270         


Phe Ile Phe Glu His Ile Ile Lys Arg Met Ala Pro Ser Ile Met Lys 
        275                 280                 285             


Ser Leu Met Asp His Thr Ile Pro Glu Val 
    290                 295             


<210>  3329
<211>  541
<212>  PRT
<213>  Homo sapiens

<400>  3329

Met Val Ala Asp Pro Pro Arg Asp Ser Lys Gly Leu Ala Ala Ala Glu 
1               5                   10                  15      


Pro Thr Ala Asn Gly Gly Leu Ala Leu Ala Ser Ile Glu Asp Gln Gly 
            20                  25                  30          


Ala Ala Ala Gly Gly Tyr Cys Gly Ser Arg Asp Gln Val Arg Arg Cys 
        35                  40                  45              


Leu Arg Ala Asn Leu Leu Val Leu Leu Thr Val Val Ala Val Val Ala 
    50                  55                  60                  


Gly Val Ala Leu Gly Leu Gly Val Ser Gly Ala Gly Gly Ala Leu Ala 
65                  70                  75                  80  


Leu Gly Pro Glu Arg Leu Ser Ala Phe Val Phe Pro Gly Glu Leu Leu 
                85                  90                  95      


Leu Arg Leu Leu Arg Met Ile Ile Leu Pro Leu Val Val Cys Ser Leu 
            100                 105                 110         


Ile Gly Gly Ala Ala Ser Leu Asp Pro Gly Ala Leu Gly Arg Leu Gly 
        115                 120                 125             


Ala Trp Ala Leu Leu Phe Phe Leu Val Thr Thr Leu Leu Ala Ser Ala 
    130                 135                 140                 


Leu Gly Val Gly Leu Ala Leu Ala Leu Gln Pro Gly Ala Ala Ser Ala 
145                 150                 155                 160 


Ala Ile Asn Ala Ser Val Gly Ala Ala Gly Ser Ala Glu Asn Ala Pro 
                165                 170                 175     


Ser Lys Glu Val Leu Asp Ser Phe Leu Asp Leu Ala Arg Asn Ile Phe 
            180                 185                 190         


Pro Ser Asn Leu Val Ser Ala Ala Phe Arg Ser Tyr Ser Thr Thr Tyr 
        195                 200                 205             


Glu Glu Arg Asn Ile Thr Gly Thr Arg Val Lys Val Pro Val Gly Gln 
    210                 215                 220                 


Glu Val Glu Gly Met Asn Ile Leu Gly Leu Val Val Phe Ala Ile Val 
225                 230                 235                 240 


Phe Gly Val Ala Leu Arg Lys Leu Gly Pro Glu Gly Glu Leu Leu Ile 
                245                 250                 255     


Arg Phe Phe Asn Ser Phe Asn Glu Ala Thr Met Val Leu Val Ser Trp 
            260                 265                 270         


Ile Met Trp Tyr Ala Pro Val Gly Ile Met Phe Leu Val Ala Gly Lys 
        275                 280                 285             


Ile Val Glu Met Glu Asp Val Gly Leu Leu Phe Ala Arg Leu Gly Lys 
    290                 295                 300                 


Tyr Ile Leu Cys Cys Leu Leu Gly His Ala Ile His Gly Leu Leu Val 
305                 310                 315                 320 


Leu Pro Leu Ile Tyr Phe Leu Phe Thr Arg Lys Asn Pro Tyr Arg Phe 
                325                 330                 335     


Leu Trp Gly Ile Val Thr Pro Leu Ala Thr Ala Phe Gly Thr Ser Ser 
            340                 345                 350         


Ser Ser Ala Thr Leu Pro Leu Met Met Lys Cys Val Glu Glu Asn Asn 
        355                 360                 365             


Gly Val Ala Lys His Ile Ser Arg Phe Ile Leu Pro Ile Gly Ala Thr 
    370                 375                 380                 


Val Asn Met Asp Gly Ala Ala Leu Phe Gln Cys Val Ala Ala Val Phe 
385                 390                 395                 400 


Ile Ala Gln Leu Ser Gln Gln Ser Leu Asp Phe Val Lys Ile Ile Thr 
                405                 410                 415     


Ile Leu Val Thr Ala Thr Ala Ser Ser Val Gly Ala Ala Gly Ile Pro 
            420                 425                 430         


Ala Gly Gly Val Leu Thr Leu Ala Ile Ile Leu Glu Ala Val Asn Leu 
        435                 440                 445             


Pro Val Asp His Ile Ser Leu Ile Leu Ala Val Asp Trp Leu Val Asp 
    450                 455                 460                 


Arg Ser Cys Thr Val Leu Asn Val Glu Gly Asp Ala Leu Gly Ala Gly 
465                 470                 475                 480 


Leu Leu Gln Asn Tyr Val Asp Arg Thr Glu Ser Arg Ser Thr Glu Pro 
                485                 490                 495     


Glu Leu Ile Gln Val Lys Ser Glu Leu Pro Leu Asp Pro Leu Pro Val 
            500                 505                 510         


Pro Thr Glu Glu Gly Asn Pro Leu Leu Lys His Tyr Arg Gly Pro Ala 
        515                 520                 525             


Gly Asp Ala Thr Val Ala Ser Glu Lys Glu Ser Val Met 
    530                 535                 540     


<210>  3330
<211>  635
<212>  PRT
<213>  Homo sapiens

<400>  3330

Met Ala Lys Lys Ser Ala Glu Asn Gly Ile Tyr Ser Val Ser Gly Asp 
1               5                   10                  15      


Glu Lys Lys Gly Pro Leu Ile Ala Pro Gly Pro Asp Gly Ala Pro Ala 
            20                  25                  30          


Lys Gly Asp Gly Pro Val Gly Leu Gly Thr Pro Gly Gly Arg Leu Ala 
        35                  40                  45              


Val Pro Pro Arg Glu Thr Trp Thr Arg Gln Met Asp Phe Ile Met Ser 
    50                  55                  60                  


Cys Val Gly Phe Ala Val Gly Leu Gly Asn Val Trp Arg Phe Pro Tyr 
65                  70                  75                  80  


Leu Cys Tyr Lys Asn Gly Gly Gly Val Phe Leu Ile Pro Tyr Val Leu 
                85                  90                  95      


Ile Ala Leu Val Gly Gly Ile Pro Ile Phe Phe Leu Glu Ile Ser Leu 
            100                 105                 110         


Gly Gln Phe Met Lys Ala Gly Ser Ile Asn Val Trp Asn Ile Cys Pro 
        115                 120                 125             


Leu Phe Lys Gly Leu Gly Tyr Ala Ser Met Val Ile Val Phe Tyr Cys 
    130                 135                 140                 


Asn Thr Tyr Tyr Ile Met Val Leu Ala Trp Gly Phe Tyr Tyr Leu Val 
145                 150                 155                 160 


Lys Ser Phe Thr Thr Thr Leu Pro Trp Ala Thr Cys Gly His Thr Trp 
                165                 170                 175     


Asn Thr Pro Asp Cys Val Glu Ile Phe Arg His Glu Asp Cys Ala Asn 
            180                 185                 190         


Ala Ser Leu Ala Asn Leu Thr Cys Asp Gln Leu Ala Asp Arg Arg Ser 
        195                 200                 205             


Pro Val Ile Glu Phe Trp Glu Asn Lys Val Leu Arg Leu Ser Gly Gly 
    210                 215                 220                 


Leu Glu Val Pro Gly Ala Leu Asn Trp Glu Val Thr Leu Cys Leu Leu 
225                 230                 235                 240 


Ala Cys Trp Val Leu Val Tyr Phe Cys Val Trp Lys Gly Val Lys Ser 
                245                 250                 255     


Thr Gly Lys Ile Val Tyr Phe Thr Ala Thr Phe Pro Tyr Val Val Leu 
            260                 265                 270         


Val Val Leu Leu Val Arg Gly Val Leu Leu Pro Gly Ala Leu Asp Gly 
        275                 280                 285             


Ile Ile Tyr Tyr Leu Lys Pro Asp Trp Ser Lys Leu Gly Ser Pro Gln 
    290                 295                 300                 


Val Trp Ile Asp Ala Gly Thr Gln Ile Phe Phe Ser Tyr Ala Ile Gly 
305                 310                 315                 320 


Leu Gly Ala Leu Thr Ala Leu Gly Ser Tyr Asn Arg Phe Asn Asn Asn 
                325                 330                 335     


Cys Tyr Lys Asp Ala Ile Ile Leu Ala Leu Ile Asn Ser Gly Thr Ser 
            340                 345                 350         


Phe Phe Ala Gly Phe Val Val Phe Ser Ile Leu Gly Phe Met Ala Ala 
        355                 360                 365             


Glu Gln Gly Val His Ile Ser Lys Val Ala Glu Ser Gly Pro Gly Leu 
    370                 375                 380                 


Ala Phe Ile Ala Tyr Pro Arg Ala Val Thr Leu Met Pro Val Ala Pro 
385                 390                 395                 400 


Leu Trp Ala Ala Leu Phe Phe Phe Met Leu Leu Leu Leu Gly Leu Asp 
                405                 410                 415     


Ser Gln Phe Val Gly Val Glu Gly Phe Ile Thr Gly Leu Leu Asp Leu 
            420                 425                 430         


Leu Pro Ala Ser Tyr Tyr Phe Arg Phe Gln Arg Glu Ile Ser Val Ala 
        435                 440                 445             


Leu Cys Cys Ala Leu Cys Phe Val Ile Asp Leu Ser Met Val Thr Asp 
    450                 455                 460                 


Gly Gly Met Tyr Val Phe Gln Leu Phe Asp Tyr Tyr Ser Ala Ser Gly 
465                 470                 475                 480 


Thr Thr Leu Leu Trp Gln Ala Phe Trp Glu Cys Val Val Val Ala Trp 
                485                 490                 495     


Val Tyr Gly Ala Asp Arg Phe Met Asp Asp Ile Ala Cys Met Ile Gly 
            500                 505                 510         


Tyr Arg Pro Cys Pro Trp Met Lys Trp Cys Trp Ser Phe Phe Thr Pro 
        515                 520                 525             


Leu Val Cys Met Gly Ile Phe Ile Phe Asn Val Val Tyr Tyr Glu Pro 
    530                 535                 540                 


Leu Val Tyr Asn Asn Thr Tyr Val Tyr Pro Trp Trp Gly Glu Ala Met 
545                 550                 555                 560 


Gly Trp Ala Phe Ala Leu Ser Ser Met Leu Cys Val Pro Leu His Leu 
                565                 570                 575     


Leu Gly Cys Leu Leu Arg Ala Lys Gly Thr Met Ala Glu Arg Trp Gln 
            580                 585                 590         


His Leu Thr Gln Pro Ile Trp Gly Leu His His Leu Glu Tyr Arg Ala 
        595                 600                 605             


Gln Asp Ala Asp Val Arg Gly Leu Thr Thr Leu Thr Pro Val Ser Glu 
    610                 615                 620                 


Ser Ser Lys Val Val Val Val Glu Ser Val Met 
625                 630                 635 


<210>  3331
<211>  643
<212>  PRT
<213>  Homo sapiens

<400>  3331

Met Gly Leu Leu Pro Lys Leu Gly Ala Ser Gln Gly Ser Asp Thr Ser 
1               5                   10                  15      


Thr Ser Arg Ala Gly Arg Cys Ala Arg Ser Val Phe Gly Asn Ile Lys 
            20                  25                  30          


Val Phe Val Leu Cys Gln Gly Leu Leu Gln Leu Cys Gln Leu Leu Tyr 
        35                  40                  45              


Ser Ala Tyr Phe Lys Ser Ser Leu Thr Thr Ile Glu Lys Arg Phe Gly 
    50                  55                  60                  


Leu Ser Ser Ser Ser Ser Gly Leu Ile Ser Ser Leu Asn Glu Ile Ser 
65                  70                  75                  80  


Asn Ala Ile Leu Ile Ile Phe Val Ser Tyr Phe Gly Ser Arg Val His 
                85                  90                  95      


Arg Pro Arg Leu Ile Gly Ile Gly Gly Leu Phe Leu Ala Ala Gly Ala 
            100                 105                 110         


Phe Ile Leu Thr Leu Pro His Phe Leu Ser Glu Pro Tyr Gln Tyr Thr 
        115                 120                 125             


Leu Ala Ser Thr Gly Asn Asn Ser Arg Leu Gln Ala Glu Leu Cys Gln 
    130                 135                 140                 


Lys His Trp Gln Asp Leu Pro Pro Ser Lys Cys His Ser Thr Thr Gln 
145                 150                 155                 160 


Asn Pro Gln Lys Glu Thr Ser Ser Met Trp Gly Leu Met Val Val Ala 
                165                 170                 175     


Gln Leu Leu Ala Gly Ile Gly Thr Val Pro Ile Gln Pro Phe Gly Ile 
            180                 185                 190         


Ser Tyr Val Asp Asp Phe Ser Glu Pro Ser Asn Ser Pro Leu Tyr Ile 
        195                 200                 205             


Ser Ile Leu Phe Ala Ile Ser Val Phe Gly Pro Ala Phe Gly Tyr Leu 
    210                 215                 220                 


Leu Gly Ser Val Met Leu Gln Ile Phe Val Asp Tyr Gly Arg Val Asn 
225                 230                 235                 240 


Thr Ala Ala Val Asn Leu Val Pro Gly Asp Pro Arg Trp Ile Gly Ala 
                245                 250                 255     


Trp Trp Leu Gly Leu Leu Ile Ser Ser Ala Leu Leu Val Leu Thr Ser 
            260                 265                 270         


Phe Pro Phe Phe Phe Phe Pro Arg Ala Met Pro Ile Gly Ala Lys Arg 
        275                 280                 285             


Ala Pro Ala Thr Ala Asp Glu Ala Arg Lys Leu Glu Glu Ala Lys Ser 
    290                 295                 300                 


Arg Gly Ser Leu Val Asp Phe Ile Lys Arg Phe Pro Cys Ile Phe Leu 
305                 310                 315                 320 


Arg Leu Leu Met Asn Ser Leu Phe Val Leu Val Val Leu Ala Gln Cys 
                325                 330                 335     


Thr Phe Ser Ser Val Ile Ala Gly Leu Ser Thr Phe Leu Asn Lys Phe 
            340                 345                 350         


Leu Glu Lys Gln Tyr Gly Thr Ser Ala Ala Tyr Ala Asn Phe Leu Ile 
        355                 360                 365             


Gly Ala Val Asn Leu Pro Ala Ala Ala Leu Gly Met Leu Phe Gly Gly 
    370                 375                 380                 


Ile Leu Met Lys Arg Phe Val Phe Ser Leu Gln Ala Ile Pro Arg Ile 
385                 390                 395                 400 


Ala Thr Thr Ile Ile Thr Ile Ser Met Ile Leu Cys Val Pro Leu Phe 
                405                 410                 415     


Phe Met Gly Cys Ser Thr Pro Thr Val Ala Glu Val Tyr Pro Pro Ser 
            420                 425                 430         


Thr Ser Ser Ser Ile His Pro Gln Ser Pro Ala Cys Arg Arg Asp Cys 
        435                 440                 445             


Ser Cys Pro Asp Ser Ile Phe His Pro Val Cys Gly Asp Asn Gly Ile 
    450                 455                 460                 


Glu Tyr Leu Ser Pro Cys His Ala Gly Cys Ser Asn Ile Asn Met Ser 
465                 470                 475                 480 


Ser Ala Thr Ser Lys Gln Leu Ile Tyr Leu Asn Cys Ser Cys Val Thr 
                485                 490                 495     


Gly Gly Ser Ala Ser Ala Lys Thr Gly Ser Cys Pro Val Pro Cys Ala 
            500                 505                 510         


His Phe Leu Leu Pro Ala Ile Phe Leu Ile Ser Phe Val Ser Leu Ile 
        515                 520                 525             


Ala Cys Ile Ser His Asn Pro Leu Tyr Met Met Val Leu Arg Val Val 
    530                 535                 540                 


Asn Gln Glu Glu Lys Ser Phe Ala Ile Gly Val Gln Phe Leu Leu Met 
545                 550                 555                 560 


Arg Leu Leu Ala Trp Leu Pro Ser Pro Ala Leu Tyr Gly Leu Thr Ile 
                565                 570                 575     


Asp His Ser Cys Ile Arg Trp Asn Ser Leu Cys Leu Gly Arg Arg Gly 
            580                 585                 590         


Ala Cys Ala Tyr Tyr Asp Asn Asp Ala Leu Arg Asp Arg Tyr Leu Gly 
        595                 600                 605             


Leu Gln Met Gly Tyr Lys Ala Leu Gly Met Leu Leu Leu Cys Phe Ile 
    610                 615                 620                 


Ser Trp Arg Val Lys Lys Asn Lys Glu Tyr Asn Val Gln Lys Ala Ala 
625                 630                 635                 640 


Gly Leu Ile 
            


<210>  3332
<211>  787
<212>  PRT
<213>  Homo sapiens

<400>  3332

Met Ala Ala Ala Arg Pro Ala Arg Gly Pro Glu Leu Pro Leu Leu Gly 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Asp Pro Gly Arg Gly Ala Ala Ser 
            20                  25                  30          


Ser Gly Asn Ala Thr Gly Pro Gly Pro Arg Ser Ala Gly Gly Ser Ala 
        35                  40                  45              


Arg Arg Ser Ala Ala Val Thr Gly Pro Pro Pro Pro Leu Ser His Cys 
    50                  55                  60                  


Gly Arg Ala Ala Pro Cys Glu Pro Leu Arg Tyr Asn Val Cys Leu Gly 
65                  70                  75                  80  


Ser Val Leu Pro Tyr Gly Ala Thr Ser Thr Leu Leu Ala Gly Asp Ser 
                85                  90                  95      


Asp Ser Gln Glu Glu Ala His Gly Lys Leu Val Leu Trp Ser Gly Leu 
            100                 105                 110         


Arg Asn Ala Pro Arg Cys Trp Ala Val Ile Gln Pro Leu Leu Cys Ala 
        115                 120                 125             


Val Tyr Met Pro Lys Cys Glu Asn Asp Arg Val Glu Leu Pro Ser Arg 
    130                 135                 140                 


Thr Leu Cys Gln Ala Thr Arg Gly Pro Cys Ala Ile Val Glu Arg Glu 
145                 150                 155                 160 


Arg Gly Trp Pro Asp Phe Leu Arg Cys Thr Pro Asp Arg Phe Pro Glu 
                165                 170                 175     


Gly Cys Thr Asn Glu Val Gln Asn Ile Lys Phe Asn Ser Ser Gly Gln 
            180                 185                 190         


Cys Glu Val Pro Leu Val Arg Thr Asp Asn Pro Lys Ser Trp Tyr Glu 
        195                 200                 205             


Asp Val Glu Gly Cys Gly Ile Gln Cys Gln Asn Pro Leu Phe Thr Glu 
    210                 215                 220                 


Ala Glu His Gln Asp Met His Ser Tyr Ile Ala Ala Phe Gly Ala Val 
225                 230                 235                 240 


Thr Gly Leu Cys Thr Leu Phe Thr Leu Ala Thr Phe Val Ala Asp Trp 
                245                 250                 255     


Arg Asn Ser Asn Arg Tyr Pro Ala Val Ile Leu Phe Tyr Val Asn Ala 
            260                 265                 270         


Cys Phe Phe Val Gly Ser Ile Gly Trp Leu Ala Gln Phe Met Asp Gly 
        275                 280                 285             


Ala Arg Arg Glu Ile Val Cys Arg Ala Asp Gly Thr Met Arg Leu Gly 
    290                 295                 300                 


Glu Pro Thr Ser Asn Glu Thr Leu Ser Cys Val Ile Ile Phe Val Ile 
305                 310                 315                 320 


Val Tyr Tyr Ala Leu Met Ala Gly Val Val Trp Phe Val Val Leu Thr 
                325                 330                 335     


Tyr Ala Trp His Thr Ser Phe Lys Ala Leu Gly Thr Thr Tyr Gln Pro 
            340                 345                 350         


Leu Ser Gly Lys Thr Ser Tyr Phe His Leu Leu Thr Trp Ser Leu Pro 
        355                 360                 365             


Phe Val Leu Thr Val Ala Ile Leu Ala Val Ala Gln Val Asp Gly Asp 
    370                 375                 380                 


Ser Val Ser Gly Ile Cys Phe Val Gly Tyr Lys Asn Tyr Arg Tyr Arg 
385                 390                 395                 400 


Ala Gly Phe Val Leu Ala Pro Ile Gly Leu Val Leu Ile Val Gly Gly 
                405                 410                 415     


Tyr Phe Leu Ile Arg Gly Val Met Thr Leu Phe Ser Ile Lys Ser Asn 
            420                 425                 430         


His Pro Gly Leu Leu Ser Glu Lys Ala Ala Ser Lys Ile Asn Glu Thr 
        435                 440                 445             


Met Leu Arg Leu Gly Ile Phe Gly Phe Leu Ala Phe Gly Phe Val Leu 
    450                 455                 460                 


Ile Thr Phe Ser Cys His Phe Tyr Asp Phe Phe Asn Gln Ala Glu Trp 
465                 470                 475                 480 


Glu Arg Ser Phe Arg Asp Tyr Val Leu Cys Gln Ala Asn Val Thr Ile 
                485                 490                 495     


Gly Leu Pro Thr Lys Gln Pro Ile Pro Asp Cys Glu Ile Lys Asn Arg 
            500                 505                 510         


Pro Ser Leu Leu Val Glu Lys Ile Asn Leu Phe Ala Met Phe Gly Thr 
        515                 520                 525             


Gly Ile Ala Met Ser Thr Trp Val Trp Thr Lys Ala Thr Leu Leu Ile 
    530                 535                 540                 


Trp Arg Arg Thr Trp Cys Arg Leu Thr Gly Gln Ser Asp Asp Glu Pro 
545                 550                 555                 560 


Lys Arg Ile Lys Lys Ser Lys Met Ile Ala Lys Ala Phe Ser Lys Arg 
                565                 570                 575     


His Glu Leu Leu Gln Asn Pro Gly Gln Glu Leu Ser Phe Ser Met His 
            580                 585                 590         


Thr Val Ser His Asp Gly Pro Val Ala Gly Leu Ala Phe Asp Leu Asn 
        595                 600                 605             


Glu Pro Ser Ala Asp Val Ser Ser Ala Trp Ala Gln His Val Thr Lys 
    610                 615                 620                 


Met Val Ala Arg Arg Gly Ala Ile Leu Pro Gln Asp Ile Ser Val Thr 
625                 630                 635                 640 


Pro Val Ala Thr Pro Val Pro Pro Glu Glu Gln Ala Asn Leu Trp Leu 
                645                 650                 655     


Val Glu Ala Glu Ile Ser Pro Glu Leu Gln Lys Arg Leu Gly Arg Lys 
            660                 665                 670         


Lys Lys Arg Arg Lys Arg Lys Lys Glu Val Cys Pro Leu Ala Pro Pro 
        675                 680                 685             


Pro Glu Leu His Pro Pro Ala Pro Ala Pro Ser Thr Ile Pro Arg Leu 
    690                 695                 700                 


Pro Gln Leu Pro Arg Gln Lys Cys Leu Val Ala Ala Gly Ala Trp Gly 
705                 710                 715                 720 


Ala Gly Asp Ser Cys Arg Gln Gly Ala Trp Thr Leu Val Ser Asn Pro 
                725                 730                 735     


Phe Cys Pro Glu Pro Ser Pro Pro Gln Asp Pro Phe Leu Pro Ser Ala 
            740                 745                 750         


Pro Ala Pro Val Ala Trp Ala His Gly Arg Arg Gln Gly Leu Gly Pro 
        755                 760                 765             


Ile His Ser Arg Thr Asn Leu Met Asp Thr Glu Leu Met Asp Ala Asp 
    770                 775                 780                 


Ser Asp Phe 
785         


<210>  3333
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  3333

Met Ala Ile Leu Phe Ala Val Val Ala Arg Gly Thr Thr Ile Leu Ala 
1               5                   10                  15      


Lys His Ala Trp Cys Gly Gly Asn Phe Leu Glu Val Thr Glu Gln Ile 
            20                  25                  30          


Leu Ala Lys Ile Pro Ser Glu Asn Asn Lys Leu Thr Tyr Ser His Gly 
        35                  40                  45              


Asn Tyr Leu Phe His Tyr Ile Cys Gln Asp Arg Ile Val Tyr Leu Cys 
    50                  55                  60                  


Ile Thr Asp Asp Asp Phe Glu Arg Ser Arg Ala Phe Asn Phe Leu Asn 
65                  70                  75                  80  


Glu Ile Lys Lys Arg Phe Gln Thr Thr Tyr Gly Ser Arg Ala Gln Thr 
                85                  90                  95      


Ala Leu Pro Tyr Ala Met Asn Ser Glu Phe Ser Ser Val Leu Ala Ala 
            100                 105                 110         


Gln Leu Lys His His Ser Glu Asn Lys Gly Leu Asp Lys Val Met Glu 
        115                 120                 125             


Thr Gln Ala Gln Val Asp Glu Leu Lys Gly Ile Met Val Arg Asn Ile 
    130                 135                 140                 


Asp Leu Val Ala Gln Arg Gly Glu Arg Leu Glu Leu Leu Ile Asp Lys 
145                 150                 155                 160 


Thr Glu Asn Leu Val Asp Ser Ser Val Thr Phe Lys Thr Thr Ser Arg 
                165                 170                 175     


Asn Leu Ala Arg Ala Met Cys Met Lys Asn Leu Lys Leu Thr Ile Ile 
            180                 185                 190         


Ile Ile Ile Val Ser Ile Val Phe Ile Tyr Ile Ile Val Ser Pro Leu 
        195                 200                 205             


Cys Gly Gly Phe Thr Trp Pro Ser Cys Val Lys Lys 
    210                 215                 220 


<210>  3334
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  3334

Met Val Ser Glu Ser His His Glu Ala Leu Ala Ala Pro Pro Val Thr 
1               5                   10                  15      


Thr Val Ala Thr Val Leu Pro Ser Asn Ala Thr Glu Pro Ala Ser Pro 
            20                  25                  30          


Gly Glu Gly Lys Glu Asp Ala Phe Ser Lys Leu Lys Glu Lys Phe Met 
        35                  40                  45              


Asn Glu Leu His Lys Ile Pro Leu Pro Pro Trp Ala Leu Ile Ala Ile 
    50                  55                  60                  


Ala Ile Val Ala Val Leu Leu Val Leu Thr Cys Cys Phe Cys Ile Cys 
65                  70                  75                  80  


Lys Lys Cys Leu Phe Lys Lys Lys Asn Lys Lys Lys Gly Lys Glu Lys 
                85                  90                  95      


Gly Gly Lys Asn Ala Ile Asn Met Lys Asp Val Lys Asp Leu Gly Lys 
            100                 105                 110         


Thr Met Lys Asp Gln Ala Leu Lys Asp Asp Asp Ala Glu Thr Gly Leu 
        115                 120                 125             


Thr Asp Gly Glu Glu Lys Glu Glu Pro Lys Glu Glu Glu Lys Leu Gly 
    130                 135                 140                 


Lys Leu Gln Tyr Ser Leu Asp Tyr Asp Phe Gln Asn Asn Gln Leu Leu 
145                 150                 155                 160 


Val Gly Ile Ile Gln Ala Ala Glu Leu Pro Ala Leu Asp Met Gly Gly 
                165                 170                 175     


Thr Ser Asp Pro Tyr Val Lys Val Phe Leu Leu Pro Asp Lys Lys Lys 
            180                 185                 190         


Lys Phe Glu Thr Lys Val His Arg Lys Thr Leu Asn Pro Val Phe Asn 
        195                 200                 205             


Glu Gln Phe Thr Phe Lys Val Pro Tyr Ser Glu Leu Gly Gly Lys Thr 
    210                 215                 220                 


Leu Val Met Ala Val Tyr Asp Phe Asp Arg Phe Ser Lys His Asp Ile 
225                 230                 235                 240 


Ile Gly Glu Phe Lys Val Pro Met Asn Thr Val Asp Phe Gly His Val 
                245                 250                 255     


Thr Glu Glu Trp Arg Asp Leu Gln Ser Ala Glu Lys Glu Glu Gln Glu 
            260                 265                 270         


Lys Leu Gly Asp Ile Cys Phe Ser Leu Arg Tyr Val Pro Thr Ala Gly 
        275                 280                 285             


Lys Leu Thr Val Val Ile Leu Glu Ala Lys Asn Leu Lys Lys Met Asp 
    290                 295                 300                 


Val Gly Gly Leu Ser Asp Pro Tyr Val Lys Ile His Leu Met Gln Asn 
305                 310                 315                 320 


Gly Lys Arg Leu Lys Lys Lys Lys Thr Thr Ile Lys Lys Asn Thr Leu 
                325                 330                 335     


Asn Pro Tyr Tyr Asn Glu Ser Phe Ser Phe Glu Val Pro Phe Glu Gln 
            340                 345                 350         


Ile Gln Lys Val Gln Val Val Val Thr Val Leu Asp Tyr Asp Lys Ile 
        355                 360                 365             


Gly Lys Asn Asp Ala Ile Gly Lys Val Phe Val Gly Tyr Asn Ser Thr 
    370                 375                 380                 


Gly Ala Glu Leu Arg His Trp Ser Asp Met Leu Ala Asn Pro Arg Arg 
385                 390                 395                 400 


Pro Ile Ala Gln Trp His Thr Leu Gln Val Glu Glu Glu Val Asp Ala 
                405                 410                 415     


Met Leu Ala Val Lys Lys 
            420         


<210>  3335
<211>  492
<212>  PRT
<213>  Homo sapiens

<400>  3335

Met Ala Leu Asn Ser Gly Ser Pro Pro Ala Ile Gly Pro Tyr Tyr Glu 
1               5                   10                  15      


Asn His Gly Tyr Gln Pro Glu Asn Pro Tyr Pro Ala Gln Pro Thr Val 
            20                  25                  30          


Val Pro Thr Val Tyr Glu Val His Pro Ala Gln Tyr Tyr Pro Ser Pro 
        35                  40                  45              


Val Pro Gln Tyr Ala Pro Arg Val Leu Thr Gln Ala Ser Asn Pro Val 
    50                  55                  60                  


Val Cys Thr Gln Pro Lys Ser Pro Ser Gly Thr Val Cys Thr Ser Lys 
65                  70                  75                  80  


Thr Lys Lys Ala Leu Cys Ile Thr Leu Thr Leu Gly Thr Phe Leu Val 
                85                  90                  95      


Gly Ala Ala Leu Ala Ala Gly Leu Leu Trp Lys Phe Met Gly Ser Lys 
            100                 105                 110         


Cys Ser Asn Ser Gly Ile Glu Cys Asp Ser Ser Gly Thr Cys Ile Asn 
        115                 120                 125             


Pro Ser Asn Trp Cys Asp Gly Val Ser His Cys Pro Gly Gly Glu Asp 
    130                 135                 140                 


Glu Asn Arg Cys Val Arg Leu Tyr Gly Pro Asn Phe Ile Leu Gln Val 
145                 150                 155                 160 


Tyr Ser Ser Gln Arg Lys Ser Trp His Pro Val Cys Gln Asp Asp Trp 
                165                 170                 175     


Asn Glu Asn Tyr Gly Arg Ala Ala Cys Arg Asp Met Gly Tyr Lys Asn 
            180                 185                 190         


Asn Phe Tyr Ser Ser Gln Gly Ile Val Asp Asp Ser Gly Ser Thr Ser 
        195                 200                 205             


Phe Met Lys Leu Asn Thr Ser Ala Gly Asn Val Asp Ile Tyr Lys Lys 
    210                 215                 220                 


Leu Tyr His Ser Asp Ala Cys Ser Ser Lys Ala Val Val Ser Leu Arg 
225                 230                 235                 240 


Cys Ile Ala Cys Gly Val Asn Leu Asn Ser Ser Arg Gln Ser Arg Ile 
                245                 250                 255     


Val Gly Gly Glu Ser Ala Leu Pro Gly Ala Trp Pro Trp Gln Val Ser 
            260                 265                 270         


Leu His Val Gln Asn Val His Val Cys Gly Gly Ser Ile Ile Thr Pro 
        275                 280                 285             


Glu Trp Ile Val Thr Ala Ala His Cys Val Glu Lys Pro Leu Asn Asn 
    290                 295                 300                 


Pro Trp His Trp Thr Ala Phe Ala Gly Ile Leu Arg Gln Ser Phe Met 
305                 310                 315                 320 


Phe Tyr Gly Ala Gly Tyr Gln Val Glu Lys Val Ile Ser His Pro Asn 
                325                 330                 335     


Tyr Asp Ser Lys Thr Lys Asn Asn Asp Ile Ala Leu Met Lys Leu Gln 
            340                 345                 350         


Lys Pro Leu Thr Phe Asn Asp Leu Val Lys Pro Val Cys Leu Pro Asn 
        355                 360                 365             


Pro Gly Met Met Leu Gln Pro Glu Gln Leu Cys Trp Ile Ser Gly Trp 
    370                 375                 380                 


Gly Ala Thr Glu Glu Lys Gly Lys Thr Ser Glu Val Leu Asn Ala Ala 
385                 390                 395                 400 


Lys Val Leu Leu Ile Glu Thr Gln Arg Cys Asn Ser Arg Tyr Val Tyr 
                405                 410                 415     


Asp Asn Leu Ile Thr Pro Ala Met Ile Cys Ala Gly Phe Leu Gln Gly 
            420                 425                 430         


Asn Val Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Thr Ser 
        435                 440                 445             


Lys Asn Asn Ile Trp Trp Leu Ile Gly Asp Thr Ser Trp Gly Ser Gly 
    450                 455                 460                 


Cys Ala Lys Ala Tyr Arg Pro Gly Val Tyr Gly Asn Val Met Val Phe 
465                 470                 475                 480 


Thr Asp Trp Ile Tyr Arg Gln Met Arg Ala Asp Gly 
                485                 490         


<210>  3336
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  3336

Met Ala Ala Val Gly Ala Gly Gly Ser Thr Ala Ala Pro Gly Pro Gly 
1               5                   10                  15      


Ala Val Ser Ala Gly Ala Leu Glu Pro Gly Thr Ala Ser Ala Ala His 
            20                  25                  30          


Arg Arg Leu Lys Tyr Ile Ser Leu Ala Val Leu Val Val Gln Asn Ala 
        35                  40                  45              


Ser Leu Ile Leu Ser Ile Arg Tyr Ala Arg Thr Leu Pro Gly Asp Arg 
    50                  55                  60                  


Phe Phe Ala Thr Thr Ala Val Val Met Ala Glu Val Leu Lys Gly Leu 
65                  70                  75                  80  


Thr Cys Leu Leu Leu Leu Phe Ala Gln Lys Arg Gly Asn Val Lys His 
                85                  90                  95      


Leu Val Leu Phe Leu His Glu Ala Val Leu Val Gln Tyr Val Asp Thr 
            100                 105                 110         


Leu Lys Leu Ala Val Pro Ser Leu Ile Tyr Thr Leu Gln Asn Asn Leu 
        115                 120                 125             


Gln Tyr Val Ala Ile Ser Asn Leu Pro Ala Ala Thr Phe Gln Val Thr 
    130                 135                 140                 


Tyr Gln Leu Lys Ile Leu Thr Thr Ala Leu Phe Ser Val Leu Met Leu 
145                 150                 155                 160 


Asn Arg Ser Leu Ser Arg Leu Gln Trp Ala Ser Leu Leu Leu Leu Phe 
                165                 170                 175     


Thr Gly Val Ala Ile Val Gln Ala Gln Gln Ala Gly Gly Gly Gly Pro 
            180                 185                 190         


Arg Pro Leu Asp Gln Asn Pro Gly Ala Gly Leu Ala Ala Val Val Ala 
        195                 200                 205             


Ser Cys Leu Ser Ser Gly Phe Ala Gly Val Tyr Phe Glu Lys Ile Leu 
    210                 215                 220                 


Lys Gly Ser Ser Gly Ser Val Trp Leu Arg Asn Leu Gln Leu Gly Leu 
225                 230                 235                 240 


Phe Gly Thr Ala Leu Gly Leu Val Gly Leu Trp Trp Ala Glu Gly Thr 
                245                 250                 255     


Ala Val Ala Thr Arg Gly Phe Phe Phe Gly Tyr Thr Pro Ala Val Trp 
            260                 265                 270         


Gly Val Val Leu Asn Gln Ala Phe Gly Gly Leu Leu Val Ala Val Val 
        275                 280                 285             


Val Lys Tyr Ala Asp Asn Ile Leu Lys Gly Phe Ala Thr Ser Leu Ser 
    290                 295                 300                 


Ile Val Leu Ser Thr Val Ala Ser Ile Arg Leu Phe Gly Phe His Val 
305                 310                 315                 320 


Asp Pro Leu Phe Ala Leu Gly Ala Gly Leu Val Ile Gly Ala Val Tyr 
                325                 330                 335     


Leu Tyr Ser Leu Pro Arg Gly Ala Ala Lys Ala Ile Ala Ser Ala Ser 
            340                 345                 350         


Ala Ser Ala Ser Gly Pro Cys Val His Gln Gln Pro Pro Gly Gln Pro 
        355                 360                 365             


Pro Pro Pro Gln Leu Ser Ser His Arg Gly Asp Leu Ile Thr Glu Pro 
    370                 375                 380                 


Phe Leu Pro Lys Leu Leu Thr Lys Val Lys Gly Ser 
385                 390                 395     


<210>  3337
<211>  685
<212>  PRT
<213>  Homo sapiens

<400>  3337

Met Trp Leu Lys Leu Phe Phe Leu Leu Leu Tyr Phe Leu Val Leu Phe 
1               5                   10                  15      


Val Leu Ala Arg Phe Phe Glu Ala Ile Val Trp Tyr Glu Thr Gly Ile 
            20                  25                  30          


Phe Ala Thr Gln Leu Val Asp Pro Val Ala Leu Ser Phe Lys Lys Leu 
        35                  40                  45              


Lys Thr Ile Leu Glu Cys Arg Gly Leu Gly Tyr Ser Gly Leu Pro Glu 
    50                  55                  60                  


Lys Lys Asp Val Arg Glu Leu Val Glu Lys Ser Gly Asp Leu Met Glu 
65                  70                  75                  80  


Gly Glu Leu Tyr Ser Ala Leu Lys Glu Glu Glu Ala Ser Glu Ser Val 
                85                  90                  95      


Ser Ser Thr Asn Phe Ser Gly Glu Met His Phe Tyr Glu Leu Val Glu 
            100                 105                 110         


Asp Thr Lys Asp Gly Ile Trp Leu Val Gln Val Ile Ala Asn Asp Arg 
        115                 120                 125             


Ser Pro Leu Val Gly Lys Ile His Trp Glu Lys Met Val Lys Lys Val 
    130                 135                 140                 


Ser Arg Phe Gly Ile Arg Thr Gly Thr Phe Asn Cys Ser Ser Asp Pro 
145                 150                 155                 160 


Arg Tyr Cys Arg Arg Arg Gly Trp Val Arg Ser Thr Leu Ile Met Ser 
                165                 170                 175     


Val Pro Gln Thr Ser Thr Ser Lys Gly Lys Val Met Leu Lys Glu Tyr 
            180                 185                 190         


Ser Gly Arg Lys Ile Glu Val Glu His Ile Phe Lys Trp Ile Thr Ala 
        195                 200                 205             


His Ala Ala Ser Arg Ile Lys Thr Ile Tyr Asn Ala Glu His Leu Lys 
    210                 215                 220                 


Glu Glu Trp Asn Lys Ser Asp Gln Tyr Trp Leu Lys Ile Tyr Leu Phe 
225                 230                 235                 240 


Ala Asn Leu Asp Gln Pro Pro Ala Phe Phe Ser Ala Leu Ser Ile Lys 
                245                 250                 255     


Phe Thr Gly Arg Val Glu Phe Ile Phe Val Asn Val Glu Asn Trp Asp 
            260                 265                 270         


Asn Lys Ser Tyr Met Thr Asp Ile Gly Ile Tyr Asn Met Pro Ser Tyr 
        275                 280                 285             


Ile Leu Arg Thr Pro Glu Gly Ile Tyr Arg Tyr Gly Asn His Thr Gly 
    290                 295                 300                 


Glu Phe Ile Ser Leu Gln Ala Met Asp Ser Phe Leu Arg Ser Leu Gln 
305                 310                 315                 320 


Pro Glu Val Asn Asp Leu Phe Val Leu Ser Leu Val Leu Val Asn Leu 
                325                 330                 335     


Met Ala Trp Met Asp Leu Phe Ile Thr Gln Gly Ala Thr Ile Lys Arg 
            340                 345                 350         


Phe Val Val Leu Ile Ser Thr Leu Gly Thr Tyr Asn Ser Leu Leu Ile 
        355                 360                 365             


Ile Ser Trp Leu Pro Val Leu Gly Phe Leu Gln Leu Pro Tyr Leu Asp 
    370                 375                 380                 


Ser Phe Tyr Glu Tyr Ser Leu Lys Leu Leu Arg Tyr Ser Asn Thr Thr 
385                 390                 395                 400 


Thr Leu Ala Ser Trp Val Arg Ala Asp Trp Met Phe Tyr Ser Ser His 
                405                 410                 415     


Pro Ala Leu Phe Leu Ser Thr Tyr Leu Gly His Gly Leu Leu Ile Asp 
            420                 425                 430         


Tyr Phe Glu Lys Lys Arg Arg Arg Asn Asn Asn Asn Asp Glu Val Asn 
        435                 440                 445             


Ala Asn Asn Leu Glu Trp Leu Ser Ser Leu Trp Asp Trp Tyr Thr Ser 
    450                 455                 460                 


Tyr Leu Phe His Pro Ile Ala Ser Phe Gln Asn Phe Pro Val Glu Ser 
465                 470                 475                 480 


Asp Trp Asp Glu Asp Pro Asp Leu Phe Leu Glu Arg Leu Ala Phe Pro 
                485                 490                 495     


Asp Leu Trp Leu His Pro Leu Ile Pro Thr Asp Tyr Ile Lys Asn Leu 
            500                 505                 510         


Pro Met Trp Arg Phe Lys Cys Leu Gly Val Gln Ser Glu Glu Glu Met 
        515                 520                 525             


Ser Glu Gly Ser Gln Asp Thr Glu Asn Asp Ser Glu Ser Glu Asn Thr 
    530                 535                 540                 


Asp Thr Leu Ser Ser Glu Lys Glu Val Phe Glu Asp Lys Gln Ser Val 
545                 550                 555                 560 


Leu His Asn Ser Pro Gly Thr Ala Ser His Cys Asp Ala Glu Ala Cys 
                565                 570                 575     


Ser Cys Ala Asn Lys Tyr Cys Gln Thr Ser Pro Cys Glu Arg Lys Gly 
            580                 585                 590         


Arg Ser Tyr Gly Ser Tyr Asn Thr Asn Glu Asp Met Glu Pro Asp Trp 
        595                 600                 605             


Leu Thr Trp Pro Ala Asp Met Leu His Cys Thr Glu Cys Val Val Cys 
    610                 615                 620                 


Leu Glu Asn Phe Glu Asn Gly Cys Leu Leu Met Gly Leu Pro Cys Gly 
625                 630                 635                 640 


His Val Phe His Gln Asn Cys Ile Val Met Trp Leu Ala Gly Gly Arg 
                645                 650                 655     


His Cys Cys Pro Val Cys Arg Trp Pro Ser Tyr Lys Lys Lys Gln Pro 
            660                 665                 670         


Tyr Ala Gln His Gln Pro Leu Ser Asn Asp Val Pro Ser 
        675                 680                 685 


<210>  3338
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  3338

Met Ser Ala Ala Met Arg Glu Arg Phe Asp Arg Phe Leu His Glu Lys 
1               5                   10                  15      


Asn Cys Met Thr Asp Leu Leu Ala Lys Leu Glu Ala Lys Thr Gly Val 
            20                  25                  30          


Asn Arg Ser Phe Ile Ala Leu Gly Val Ile Gly Leu Val Ala Leu Tyr 
        35                  40                  45              


Leu Val Phe Gly Tyr Gly Ala Ser Leu Leu Cys Asn Leu Ile Gly Phe 
    50                  55                  60                  


Gly Tyr Pro Ala Tyr Ile Ser Ile Lys Ala Ile Glu Ser Pro Asn Lys 
65                  70                  75                  80  


Glu Asp Asp Thr Gln Trp Leu Thr Tyr Trp Val Val Tyr Gly Val Phe 
                85                  90                  95      


Ser Ile Ala Glu Phe Phe Ser Asp Ile Phe Leu Ser Trp Phe Pro Phe 
            100                 105                 110         


Tyr Tyr Met Leu Lys Cys Gly Phe Leu Leu Trp Cys Met Ala Pro Ser 
        115                 120                 125             


Pro Ser Asn Gly Ala Glu Leu Leu Tyr Lys Arg Ile Ile Arg Pro Phe 
    130                 135                 140                 


Phe Leu Lys His Glu Ser Gln Met Asp Ser Val Val Lys Asp Leu Lys 
145                 150                 155                 160 


Asp Lys Ala Lys Glu Thr Ala Asp Ala Ile Thr Lys Glu Ala Lys Lys 
                165                 170                 175     


Ala Thr Val Asn Leu Leu Gly Glu Glu Lys Lys Ser Thr 
            180                 185                 


<210>  3339
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  3339

Met Ala Ser Arg Gly Val Val Gly Ile Phe Phe Leu Ser Ala Val Pro 
1               5                   10                  15      


Leu Val Cys Leu Glu Leu Arg Arg Gly Ile Pro Asp Ile Gly Ile Lys 
            20                  25                  30          


Asp Phe Leu Leu Leu Cys Gly Arg Ile Leu Leu Leu Leu Ala Leu Leu 
        35                  40                  45              


Thr Leu Ile Ile Ser Val Thr Thr Ser Trp Leu Asn Ser Phe Lys Ser 
    50                  55                  60                  


Pro Gln Val Tyr Leu Lys Glu Glu Glu Glu Lys Asn Glu Lys Arg Gln 
65                  70                  75                  80  


Lys Leu Val Arg Lys Lys Gln Gln Glu Ala Gln Gly Glu Lys Ala Ser 
                85                  90                  95      


Arg Tyr Ile Glu Asn Val Leu Lys Pro His Gln Glu Met Lys Leu Arg 
            100                 105                 110         


Lys Leu Glu Glu Arg Phe Tyr Gln Met Thr Gly Glu Ala Trp Lys Leu 
        115                 120                 125             


Ser Ser Gly His Lys Leu Gly Gly Asp Glu Gly Thr Ser Gln Thr Ser 
    130                 135                 140                 


Phe Glu Thr Ser Asn Arg Glu Ala Ala Lys Ser Gln Asn Leu Pro Lys 
145                 150                 155                 160 


Pro Leu Thr Glu Phe Pro Ser Pro Ala Glu Gln Pro Thr Cys Lys Glu 
                165                 170                 175     


Ile Pro Asp Leu Pro Glu Glu Pro Ser Gln Thr Ala Glu Glu Val Val 
            180                 185                 190         


Thr Val Ala Leu Arg Cys Pro Ser Gly Asn Val Leu Arg Arg Arg Phe 
        195                 200                 205             


Leu Lys Ser Tyr Ser Ser Gln Val Leu Phe Asp Trp Met Thr Arg Ile 
    210                 215                 220                 


Gly Tyr His Ile Ser Leu Tyr Ser Leu Ser Thr Ser Phe Pro Arg Arg 
225                 230                 235                 240 


Pro Leu Ala Val Glu Gly Gly Gln Ser Leu Glu Asp Ile Gly Ile Thr 
                245                 250                 255     


Val Asp Thr Val Leu Ile Leu Glu Glu Lys Glu Gln Thr Asn 
            260                 265                 270 


<210>  3340
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  3340

Met Ala Gly Leu Ala Leu Gln Pro Gly Thr Ala Leu Leu Cys Tyr Ser 
1               5                   10                  15      


Cys Lys Ala Gln Val Ser Asn Glu Asp Cys Leu Gln Val Glu Asn Cys 
            20                  25                  30          


Thr Gln Leu Gly Glu Gln Cys Trp Thr Ala Arg Ile Arg Ala Val Gly 
        35                  40                  45              


Leu Leu Thr Val Ile Ser Lys Gly Cys Ser Leu Asn Cys Val Asp Asp 
    50                  55                  60                  


Ser Gln Asp Tyr Tyr Val Gly Lys Lys Asn Ile Thr Cys Cys Asp Thr 
65                  70                  75                  80  


Asp Leu Cys Asn Ala Ser Gly Ala His Ala Leu Gln Pro Ala Ala Ala 
                85                  90                  95      


Ile Leu Ala Leu Leu Pro Ala Leu Gly Leu Leu Leu Trp Gly Pro Gly 
            100                 105                 110         


Gln Leu 
        


<210>  3341
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  3341

Met Ser Gln Gln Asn Thr Ser Gly Asp Cys Leu Phe Asp Gly Val Asn 
1               5                   10                  15      


Glu Leu Met Lys Thr Leu Gln Phe Ala Val His Ile Pro Thr Phe Val 
            20                  25                  30          


Leu Gly Leu Leu Leu Asn Leu Leu Ala Ile His Gly Phe Ser Thr Phe 
        35                  40                  45              


Leu Lys Asn Arg Trp Pro Asp Tyr Ala Ala Thr Ser Ile Tyr Met Ile 
    50                  55                  60                  


Asn Leu Ala Val Phe Asp Leu Leu Leu Val Leu Ser Leu Pro Phe Lys 
65                  70                  75                  80  


Met Val Leu Ser Gln Val Gln Ser Pro Phe Pro Ser Leu Cys Thr Leu 
                85                  90                  95      


Val Glu Cys Leu Tyr Phe Val Ser Met Tyr Gly Ser Val Phe Thr Ile 
            100                 105                 110         


Cys Phe Ile Ser Met Asp Arg Phe Leu Ala Ile Arg Tyr Pro Leu Leu 
        115                 120                 125             


Val Ser His Leu Arg Ser Pro Arg Lys Ile Phe Gly Ile Cys Cys Thr 
    130                 135                 140                 


Ile Trp Val Leu Val Trp Thr Gly Ser Ile Pro Ile Tyr Ser Phe His 
145                 150                 155                 160 


Gly Lys Val Glu Lys Tyr Met Cys Phe His Asn Met Ser Asp Asp Thr 
                165                 170                 175     


Trp Ser Ala Lys Val Phe Phe Pro Leu Glu Val Phe Gly Phe Leu Leu 
            180                 185                 190         


Pro Met Gly Ile Met Gly Phe Cys Cys Ser Arg Ser Ile His Ile Leu 
        195                 200                 205             


Leu Gly Arg Arg Asp His Thr Gln Asp Trp Val Gln Gln Lys Ala Cys 
    210                 215                 220                 


Ile Tyr Ser Ile Ala Ala Ser Leu Ala Val Phe Val Val Ser Phe Leu 
225                 230                 235                 240 


Pro Val His Leu Gly Phe Phe Leu Gln Phe Leu Val Arg Asn Ser Phe 
                245                 250                 255     


Ile Val Glu Cys Arg Ala Lys Gln Ser Ile Ser Phe Phe Leu Gln Leu 
            260                 265                 270         


Ser Met Cys Phe Ser Asn Val Asn Cys Cys Leu Asp Val Phe Cys Tyr 
        275                 280                 285             


Tyr Phe Val Ile Lys Glu Phe Arg Met Asn Ile Arg Ala His Arg Pro 
    290                 295                 300                 


Ser Arg Val Gln Leu Val Leu Gln Asp Thr Thr Ile Ser Arg Gly 
305                 310                 315                 


<210>  3342
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  3342

Met Asn Glu Ser Arg Trp Thr Glu Trp Arg Ile Leu Asn Met Ser Ser 
1               5                   10                  15      


Gly Ile Val Asn Val Ser Glu Arg His Ser Cys Pro Leu Gly Phe Gly 
            20                  25                  30          


His Tyr Ser Val Val Asp Val Cys Ile Phe Glu Thr Val Val Ile Val 
        35                  40                  45              


Leu Leu Thr Phe Leu Ile Ile Ala Gly Asn Leu Thr Val Ile Phe Val 
    50                  55                  60                  


Phe His Cys Ala Pro Leu Leu His His Tyr Thr Thr Ser Tyr Phe Ile 
65                  70                  75                  80  


Gln Thr Met Ala Tyr Ala Asp Leu Phe Val Gly Val Ser Cys Leu Val 
                85                  90                  95      


Pro Thr Leu Ser Leu Leu His Tyr Ser Thr Gly Val His Glu Ser Leu 
            100                 105                 110         


Thr Cys Gln Val Phe Gly Tyr Ile Ile Ser Val Leu Lys Ser Val Ser 
        115                 120                 125             


Met Ala Cys Leu Ala Cys Ile Ser Val Asp Arg Tyr Leu Ala Ile Thr 
    130                 135                 140                 


Lys Pro Leu Ser Tyr Asn Gln Leu Val Thr Pro Cys Arg Leu Arg Ile 
145                 150                 155                 160 


Cys Ile Ile Leu Ile Trp Ile Tyr Ser Cys Leu Ile Phe Leu Pro Ser 
                165                 170                 175     


Phe Phe Gly Trp Gly Lys Pro Gly Tyr His Gly Asp Ile Phe Glu Trp 
            180                 185                 190         


Cys Ala Thr Ser Trp Leu Thr Ser Ala Tyr Phe Thr Gly Phe Ile Val 
        195                 200                 205             


Cys Leu Leu Tyr Ala Pro Ala Ala Phe Val Val Cys Phe Thr Tyr Phe 
    210                 215                 220                 


His Ile Phe Lys Ile Cys Arg Gln His Thr Lys Glu Ile Asn Asp Arg 
225                 230                 235                 240 


Arg Ala Arg Phe Pro Ser His Glu Val Asp Ser Ser Arg Glu Thr Gly 
                245                 250                 255     


His Ser Pro Asp Arg Arg Tyr Ala Met Val Leu Phe Arg Ile Thr Ser 
            260                 265                 270         


Val Phe Tyr Met Leu Trp Leu Pro Tyr Ile Ile Tyr Phe Leu Leu Glu 
        275                 280                 285             


Ser Ser Arg Val Leu Asp Asn Pro Thr Leu Ser Phe Leu Thr Thr Trp 
    290                 295                 300                 


Leu Ala Ile Ser Asn Ser Phe Cys Asn Cys Val Ile Tyr Ser Leu Ser 
305                 310                 315                 320 


Asn Ser Val Phe Arg Leu Gly Leu Arg Arg Leu Ser Glu Thr Met Cys 
                325                 330                 335     


Thr Ser Cys Met Cys Val Lys Asp Gln Glu Ala Gln Glu Pro Lys Pro 
            340                 345                 350         


Arg Lys Arg Ala Asn Ser Cys Ser Ile 
        355                 360     


<210>  3343
<211>  1437
<212>  PRT
<213>  Homo sapiens

<400>  3343

Met Lys Asp Ile Asp Ile Gly Lys Glu Tyr Ile Ile Pro Ser Pro Gly 
1               5                   10                  15      


Tyr Arg Ser Val Arg Glu Arg Thr Ser Thr Ser Gly Thr His Arg Asp 
            20                  25                  30          


Arg Glu Asp Ser Lys Phe Arg Arg Thr Arg Pro Leu Glu Cys Gln Asp 
        35                  40                  45              


Ala Leu Glu Thr Ala Ala Arg Ala Glu Gly Leu Ser Leu Asp Ala Ser 
    50                  55                  60                  


Met His Ser Gln Leu Arg Ile Leu Asp Glu Glu His Pro Lys Gly Lys 
65                  70                  75                  80  


Tyr His His Gly Leu Ser Ala Leu Lys Pro Ile Arg Thr Thr Ser Lys 
                85                  90                  95      


His Gln His Pro Val Asp Asn Ala Gly Leu Phe Ser Cys Met Thr Phe 
            100                 105                 110         


Ser Trp Leu Ser Ser Leu Ala Arg Val Ala His Lys Lys Gly Glu Leu 
        115                 120                 125             


Ser Met Glu Asp Val Trp Ser Leu Ser Lys His Glu Ser Ser Asp Val 
    130                 135                 140                 


Asn Cys Arg Arg Leu Glu Arg Leu Trp Gln Glu Glu Leu Asn Glu Val 
145                 150                 155                 160 


Gly Pro Asp Ala Ala Ser Leu Arg Arg Val Val Trp Ile Phe Cys Arg 
                165                 170                 175     


Thr Arg Leu Ile Leu Ser Ile Val Cys Leu Met Ile Thr Gln Leu Ala 
            180                 185                 190         


Gly Phe Ser Gly Pro Ala Phe Met Val Lys His Leu Leu Glu Tyr Thr 
        195                 200                 205             


Gln Ala Thr Glu Ser Asn Leu Gln Tyr Ser Leu Leu Leu Val Leu Gly 
    210                 215                 220                 


Leu Leu Leu Thr Glu Ile Val Arg Ser Trp Ser Leu Ala Leu Thr Trp 
225                 230                 235                 240 


Ala Leu Asn Tyr Arg Thr Gly Val Arg Leu Arg Gly Ala Ile Leu Thr 
                245                 250                 255     


Met Ala Phe Lys Lys Ile Leu Lys Leu Lys Asn Ile Lys Glu Lys Ser 
            260                 265                 270         


Leu Gly Glu Leu Ile Asn Ile Cys Ser Asn Asp Gly Gln Arg Met Phe 
        275                 280                 285             


Glu Ala Ala Ala Val Gly Ser Leu Leu Ala Gly Gly Pro Val Val Ala 
    290                 295                 300                 


Ile Leu Gly Met Ile Tyr Asn Val Ile Ile Leu Gly Pro Thr Gly Phe 
305                 310                 315                 320 


Leu Gly Ser Ala Val Phe Ile Leu Phe Tyr Pro Ala Met Met Phe Ala 
                325                 330                 335     


Ser Arg Leu Thr Ala Tyr Phe Arg Arg Lys Cys Val Ala Ala Thr Asp 
            340                 345                 350         


Glu Arg Val Gln Lys Met Asn Glu Val Leu Thr Tyr Ile Lys Phe Ile 
        355                 360                 365             


Lys Met Tyr Ala Trp Val Lys Ala Phe Ser Gln Ser Val Gln Lys Ile 
    370                 375                 380                 


Arg Glu Glu Glu Arg Arg Ile Leu Glu Lys Ala Gly Tyr Phe Gln Ser 
385                 390                 395                 400 


Ile Thr Val Gly Val Ala Pro Ile Val Val Val Ile Ala Ser Val Val 
                405                 410                 415     


Thr Phe Ser Val His Met Thr Leu Gly Phe Asp Leu Thr Ala Ala Gln 
            420                 425                 430         


Ala Phe Thr Val Val Thr Val Phe Asn Ser Met Thr Phe Ala Leu Lys 
        435                 440                 445             


Val Thr Pro Phe Ser Val Lys Ser Leu Ser Glu Ala Ser Val Ala Val 
    450                 455                 460                 


Asp Arg Phe Lys Ser Leu Phe Leu Met Glu Glu Val His Met Ile Lys 
465                 470                 475                 480 


Asn Lys Pro Ala Ser Pro His Ile Lys Ile Glu Met Lys Asn Ala Thr 
                485                 490                 495     


Leu Ala Trp Asp Ser Ser His Ser Ser Ile Gln Asn Ser Pro Lys Leu 
            500                 505                 510         


Thr Pro Lys Met Lys Lys Asp Lys Arg Ala Ser Arg Gly Lys Lys Glu 
        515                 520                 525             


Lys Val Arg Gln Leu Gln Arg Thr Glu His Gln Ala Val Leu Ala Glu 
    530                 535                 540                 


Gln Lys Gly His Leu Leu Leu Asp Ser Asp Glu Arg Pro Ser Pro Glu 
545                 550                 555                 560 


Glu Glu Glu Gly Lys His Ile His Leu Gly His Leu Arg Leu Gln Arg 
                565                 570                 575     


Thr Leu His Ser Ile Asp Leu Glu Ile Gln Glu Gly Lys Leu Val Gly 
            580                 585                 590         


Ile Cys Gly Ser Val Gly Ser Gly Lys Thr Ser Leu Ile Ser Ala Ile 
        595                 600                 605             


Leu Gly Gln Met Thr Leu Leu Glu Gly Ser Ile Ala Ile Ser Gly Thr 
    610                 615                 620                 


Phe Ala Tyr Val Ala Gln Gln Ala Trp Ile Leu Asn Ala Thr Leu Arg 
625                 630                 635                 640 


Asp Asn Ile Leu Phe Gly Lys Glu Tyr Asp Glu Glu Arg Tyr Asn Ser 
                645                 650                 655     


Val Leu Asn Ser Cys Cys Leu Arg Pro Asp Leu Ala Ile Leu Pro Ser 
            660                 665                 670         


Ser Asp Leu Thr Glu Ile Gly Glu Arg Gly Ala Asn Leu Ser Gly Gly 
        675                 680                 685             


Gln Arg Gln Arg Ile Ser Leu Ala Arg Ala Leu Tyr Ser Asp Arg Ser 
    690                 695                 700                 


Ile Tyr Ile Leu Asp Asp Pro Leu Ser Ala Leu Asp Ala His Val Gly 
705                 710                 715                 720 


Asn His Ile Phe Asn Ser Ala Ile Arg Lys His Leu Lys Ser Lys Thr 
                725                 730                 735     


Val Leu Phe Val Thr His Gln Leu Gln Tyr Leu Val Asp Cys Asp Glu 
            740                 745                 750         


Val Ile Phe Met Lys Glu Gly Cys Ile Thr Glu Arg Gly Thr His Glu 
        755                 760                 765             


Glu Leu Met Asn Leu Asn Gly Asp Tyr Ala Thr Ile Phe Asn Asn Leu 
    770                 775                 780                 


Leu Leu Gly Glu Thr Pro Pro Val Glu Ile Asn Ser Lys Lys Glu Thr 
785                 790                 795                 800 


Ser Gly Ser Gln Lys Lys Ser Gln Asp Lys Gly Pro Lys Thr Gly Ser 
                805                 810                 815     


Val Lys Lys Glu Lys Ala Val Lys Pro Glu Glu Gly Gln Leu Val Gln 
            820                 825                 830         


Leu Glu Glu Lys Gly Gln Gly Ser Val Pro Trp Ser Val Tyr Gly Val 
        835                 840                 845             


Tyr Ile Gln Ala Ala Gly Gly Pro Leu Ala Phe Leu Val Ile Met Ala 
    850                 855                 860                 


Leu Phe Met Leu Asn Val Gly Ser Thr Ala Phe Ser Thr Trp Trp Leu 
865                 870                 875                 880 


Ser Tyr Trp Ile Lys Gln Gly Ser Gly Asn Thr Thr Val Thr Arg Gly 
                885                 890                 895     


Asn Glu Thr Ser Val Ser Asp Ser Met Lys Asp Asn Pro His Met Gln 
            900                 905                 910         


Tyr Tyr Ala Ser Ile Tyr Ala Leu Ser Met Ala Val Met Leu Ile Leu 
        915                 920                 925             


Lys Ala Ile Arg Gly Val Val Phe Val Lys Gly Thr Leu Arg Ala Ser 
    930                 935                 940                 


Ser Arg Leu His Asp Glu Leu Phe Arg Arg Ile Leu Arg Ser Pro Met 
945                 950                 955                 960 


Lys Phe Phe Asp Thr Thr Pro Thr Gly Arg Ile Leu Asn Arg Phe Ser 
                965                 970                 975     


Lys Asp Met Asp Glu Val Asp Val Arg Leu Pro Phe Gln Ala Glu Met 
            980                 985                 990         


Phe Ile Gln Asn Val Ile Leu Val  Phe Phe Cys Val Gly  Met Ile Ala 
        995                 1000                 1005             


Gly Val  Phe Pro Trp Phe Leu  Val Ala Val Gly Pro  Leu Val Ile 
    1010                 1015                 1020             


Leu Phe  Ser Val Leu His Ile  Val Ser Arg Val Leu  Ile Arg Glu 
    1025                 1030                 1035             


Leu Lys  Arg Leu Asp Asn Ile  Thr Gln Ser Pro Phe  Leu Ser His 
    1040                 1045                 1050             


Ile Thr  Ser Ser Ile Gln Gly  Leu Ala Thr Ile His  Ala Tyr Asn 
    1055                 1060                 1065             


Lys Gly  Gln Glu Phe Leu His  Arg Tyr Gln Glu Leu  Leu Asp Asp 
    1070                 1075                 1080             


Asn Gln  Ala Pro Phe Phe Leu  Phe Thr Cys Ala Met  Arg Trp Leu 
    1085                 1090                 1095             


Ala Val  Arg Leu Asp Leu Ile  Ser Ile Ala Leu Ile  Thr Thr Thr 
    1100                 1105                 1110             


Gly Leu  Met Ile Val Leu Met  His Gly Gln Ile Pro  Pro Ala Tyr 
    1115                 1120                 1125             


Ala Gly  Leu Ala Ile Ser Tyr  Ala Val Gln Leu Thr  Gly Leu Phe 
    1130                 1135                 1140             


Gln Phe  Thr Val Arg Leu Ala  Ser Glu Thr Glu Ala  Arg Phe Thr 
    1145                 1150                 1155             


Ser Val  Glu Arg Ile Asn His  Tyr Ile Lys Thr Leu  Ser Leu Glu 
    1160                 1165                 1170             


Ala Pro  Ala Arg Ile Lys Asn  Lys Ala Pro Ser Pro  Asp Trp Pro 
    1175                 1180                 1185             


Gln Glu  Gly Glu Val Thr Phe  Glu Asn Ala Glu Met  Arg Tyr Arg 
    1190                 1195                 1200             


Glu Asn  Leu Pro Leu Val Leu  Lys Lys Val Ser Phe  Thr Ile Lys 
    1205                 1210                 1215             


Pro Lys  Glu Lys Ile Gly Ile  Val Gly Arg Thr Gly  Ser Gly Lys 
    1220                 1225                 1230             


Ser Ser  Leu Gly Met Ala Leu  Phe Arg Leu Val Glu  Leu Ser Gly 
    1235                 1240                 1245             


Gly Cys  Ile Lys Ile Asp Gly  Val Arg Ile Ser Asp  Ile Gly Leu 
    1250                 1255                 1260             


Ala Asp  Leu Arg Ser Lys Leu  Ser Ile Ile Pro Gln  Glu Pro Val 
    1265                 1270                 1275             


Leu Phe  Ser Gly Thr Val Arg  Ser Asn Leu Asp Pro  Phe Asn Gln 
    1280                 1285                 1290             


Tyr Thr  Glu Asp Gln Ile Trp  Asp Ala Leu Glu Arg  Thr His Met 
    1295                 1300                 1305             


Lys Glu  Cys Ile Ala Gln Leu  Pro Leu Lys Leu Glu  Ser Glu Val 
    1310                 1315                 1320             


Met Glu  Asn Gly Asp Asn Phe  Ser Val Gly Glu Arg  Gln Leu Leu 
    1325                 1330                 1335             


Cys Ile  Ala Arg Ala Leu Leu  Arg His Cys Lys Ile  Leu Ile Leu 
    1340                 1345                 1350             


Asp Glu  Ala Thr Ala Ala Met  Asp Thr Glu Thr Asp  Leu Leu Ile 
    1355                 1360                 1365             


Gln Glu  Thr Ile Arg Glu Ala  Phe Ala Asp Cys Thr  Met Leu Thr 
    1370                 1375                 1380             


Ile Ala  His Arg Leu His Thr  Val Leu Gly Ser Asp  Arg Ile Met 
    1385                 1390                 1395             


Val Leu  Ala Gln Gly Gln Val  Val Glu Phe Asp Thr  Pro Ser Val 
    1400                 1405                 1410             


Leu Leu  Ser Asn Asp Ser Ser  Arg Phe Tyr Ala Met  Phe Ala Ala 
    1415                 1420                 1425             


Ala Glu  Asn Lys Val Ala Val  Lys Gly 
    1430                 1435         


<210>  3344
<211>  842
<212>  PRT
<213>  Homo sapiens

<400>  3344

Met Val Thr Val Gly Asn Tyr Cys Glu Ala Glu Gly Pro Val Gly Pro 
1               5                   10                  15      


Ala Trp Met Gln Asp Gly Leu Ser Pro Cys Phe Phe Phe Thr Leu Val 
            20                  25                  30          


Pro Ser Thr Arg Met Ala Leu Gly Thr Leu Ala Leu Val Leu Ala Leu 
        35                  40                  45              


Pro Cys Arg Arg Arg Glu Arg Pro Ala Gly Ala Asp Ser Leu Ser Trp 
    50                  55                  60                  


Gly Ala Gly Pro Arg Ile Ser Pro Tyr Val Leu Gln Leu Leu Leu Ala 
65                  70                  75                  80  


Thr Leu Gln Ala Ala Leu Pro Leu Ala Gly Leu Ala Gly Arg Val Gly 
                85                  90                  95      


Thr Ala Arg Gly Ala Pro Leu Pro Ser Tyr Leu Leu Leu Ala Ser Val 
            100                 105                 110         


Leu Glu Ser Leu Ala Gly Ala Cys Gly Leu Trp Leu Leu Val Val Glu 
        115                 120                 125             


Arg Ser Gln Ala Arg Gln Arg Leu Ala Met Gly Ile Trp Ile Lys Phe 
    130                 135                 140                 


Arg His Ser Pro Gly Leu Leu Leu Leu Trp Thr Val Ala Phe Ala Ala 
145                 150                 155                 160 


Glu Asn Leu Ala Leu Val Ser Trp Asn Ser Pro Gln Trp Trp Trp Ala 
                165                 170                 175     


Arg Ala Asp Leu Gly Gln Gln Val Gln Phe Ser Leu Trp Val Leu Arg 
            180                 185                 190         


Tyr Val Val Ser Gly Gly Leu Phe Val Leu Gly Leu Trp Ala Pro Gly 
        195                 200                 205             


Leu Arg Pro Gln Ser Tyr Thr Leu Gln Val His Glu Glu Asp Gln Asp 
    210                 215                 220                 


Val Glu Arg Ser Gln Val Arg Ser Ala Ala Gln Gln Ser Thr Trp Arg 
225                 230                 235                 240 


Asp Phe Gly Arg Lys Leu Arg Leu Leu Ser Gly Tyr Leu Trp Pro Arg 
                245                 250                 255     


Gly Ser Pro Ala Leu Gln Leu Val Val Leu Ile Cys Leu Gly Leu Met 
            260                 265                 270         


Gly Leu Glu Arg Ala Leu Asn Val Leu Val Pro Ile Phe Tyr Arg Asn 
        275                 280                 285             


Ile Val Asn Leu Leu Thr Glu Lys Ala Pro Trp Asn Ser Leu Ala Trp 
    290                 295                 300                 


Thr Val Thr Ser Tyr Val Phe Leu Lys Phe Leu Gln Gly Gly Gly Thr 
305                 310                 315                 320 


Gly Ser Thr Gly Phe Val Ser Asn Leu Arg Thr Phe Leu Trp Ile Arg 
                325                 330                 335     


Val Gln Gln Phe Thr Ser Arg Arg Val Glu Leu Leu Ile Phe Ser His 
            340                 345                 350         


Leu His Glu Leu Ser Leu Arg Trp His Leu Gly Arg Arg Thr Gly Glu 
        355                 360                 365             


Val Leu Arg Ile Ala Asp Arg Gly Thr Ser Ser Val Thr Gly Leu Leu 
    370                 375                 380                 


Ser Tyr Leu Val Phe Asn Val Ile Pro Thr Leu Ala Asp Ile Ile Ile 
385                 390                 395                 400 


Gly Ile Ile Tyr Phe Ser Met Phe Phe Asn Ala Trp Phe Gly Leu Ile 
                405                 410                 415     


Val Phe Leu Cys Met Ser Leu Tyr Leu Thr Leu Thr Ile Val Val Thr 
            420                 425                 430         


Glu Trp Arg Thr Lys Phe Arg Arg Ala Met Asn Thr Gln Glu Asn Ala 
        435                 440                 445             


Thr Arg Ala Arg Ala Val Asp Ser Leu Leu Asn Phe Glu Thr Val Lys 
    450                 455                 460                 


Tyr Tyr Asn Ala Glu Ser Tyr Glu Val Glu Arg Tyr Arg Glu Ala Ile 
465                 470                 475                 480 


Ile Lys Tyr Gln Gly Leu Glu Trp Lys Ser Ser Ala Ser Leu Val Leu 
                485                 490                 495     


Leu Asn Gln Thr Gln Asn Leu Val Ile Gly Leu Gly Leu Leu Ala Gly 
            500                 505                 510         


Ser Leu Leu Cys Ala Tyr Phe Val Thr Glu Gln Lys Leu Gln Val Gly 
        515                 520                 525             


Asp Tyr Val Leu Phe Gly Thr Tyr Ile Ile Gln Leu Tyr Met Pro Leu 
    530                 535                 540                 


Asn Trp Phe Gly Thr Tyr Tyr Arg Met Ile Gln Thr Asn Phe Ile Asp 
545                 550                 555                 560 


Met Glu Asn Met Phe Asp Leu Leu Lys Glu Glu Thr Glu Val Lys Asp 
                565                 570                 575     


Leu Pro Gly Ala Gly Pro Leu Arg Phe Gln Lys Gly Arg Ile Glu Phe 
            580                 585                 590         


Glu Asn Val His Phe Ser Tyr Ala Asp Gly Arg Glu Thr Leu Gln Asp 
        595                 600                 605             


Val Ser Phe Thr Val Met Pro Gly Gln Thr Leu Ala Leu Val Gly Pro 
    610                 615                 620                 


Ser Gly Ala Gly Lys Ser Thr Ile Leu Arg Leu Leu Phe Arg Phe Tyr 
625                 630                 635                 640 


Asp Ile Ser Ser Gly Cys Ile Arg Ile Asp Gly Gln Asp Ile Ser Gln 
                645                 650                 655     


Val Thr Gln Ala Ser Leu Arg Ser His Ile Gly Val Val Pro Gln Asp 
            660                 665                 670         


Thr Val Leu Phe Asn Asp Thr Ile Ala Asp Asn Ile Arg Tyr Gly Arg 
        675                 680                 685             


Val Thr Ala Gly Asn Asp Glu Val Glu Ala Ala Ala Gln Ala Ala Gly 
    690                 695                 700                 


Ile His Asp Ala Ile Met Ala Phe Pro Glu Gly Tyr Arg Thr Gln Val 
705                 710                 715                 720 


Gly Glu Arg Gly Leu Lys Leu Ser Gly Gly Glu Lys Gln Arg Val Ala 
                725                 730                 735     


Ile Ala Arg Thr Ile Leu Lys Ala Pro Gly Ile Ile Leu Leu Asp Glu 
            740                 745                 750         


Ala Thr Ser Ala Leu Asp Thr Ser Asn Glu Arg Ala Ile Gln Ala Ser 
        755                 760                 765             


Leu Ala Lys Val Cys Ala Asn Arg Thr Thr Ile Val Val Ala His Arg 
    770                 775                 780                 


Leu Ser Thr Val Val Asn Ala Asp Gln Ile Leu Val Ile Lys Asp Gly 
785                 790                 795                 800 


Cys Ile Val Glu Arg Gly Arg His Glu Ala Leu Leu Ser Arg Gly Gly 
                805                 810                 815     


Val Tyr Ala Asp Met Trp Gln Leu Gln Gln Gly Gln Glu Glu Thr Ser 
            820                 825                 830         


Glu Asp Thr Lys Pro Gln Thr Met Glu Arg 
        835                 840         


<210>  3345
<211>  1549
<212>  PRT
<213>  Homo sapiens

<400>  3345

Met Ser Leu Ser Phe Cys Gly Asn Asn Ile Ser Ser Tyr Asn Ile Asn 
1               5                   10                  15      


Asp Gly Val Leu Gln Asn Ser Cys Phe Val Asp Ala Leu Asn Leu Val 
            20                  25                  30          


Pro His Val Phe Leu Leu Phe Ile Thr Phe Pro Ile Leu Phe Ile Gly 
        35                  40                  45              


Trp Gly Ser Gln Ser Ser Lys Val Gln Ile His His Asn Thr Trp Leu 
    50                  55                  60                  


His Phe Pro Gly His Asn Leu Arg Trp Ile Leu Thr Phe Ala Leu Leu 
65                  70                  75                  80  


Phe Val His Val Cys Glu Ile Ala Glu Gly Ile Val Ser Asp Ser Arg 
                85                  90                  95      


Arg Glu Ser Arg His Leu His Leu Phe Met Pro Ala Val Met Gly Phe 
            100                 105                 110         


Val Ala Thr Thr Thr Ser Ile Val Tyr Tyr His Asn Ile Glu Thr Ser 
        115                 120                 125             


Asn Phe Pro Lys Leu Leu Leu Ala Leu Phe Leu Tyr Trp Val Met Ala 
    130                 135                 140                 


Phe Ile Thr Lys Thr Ile Lys Leu Val Lys Tyr Cys Gln Ser Gly Leu 
145                 150                 155                 160 


Asp Ile Ser Asn Leu Arg Phe Cys Ile Thr Gly Met Met Val Ile Leu 
                165                 170                 175     


Asn Gly Leu Leu Met Ala Val Glu Ile Asn Val Ile Arg Val Arg Arg 
            180                 185                 190         


Tyr Val Phe Phe Met Asn Pro Gln Lys Val Lys Pro Pro Glu Asp Leu 
        195                 200                 205             


Gln Asp Leu Gly Val Arg Phe Leu Gln Pro Phe Val Asn Leu Leu Ser 
    210                 215                 220                 


Lys Ala Thr Tyr Trp Trp Met Asn Thr Leu Ile Ile Ser Ala His Lys 
225                 230                 235                 240 


Lys Pro Ile Asp Leu Lys Ala Ile Gly Lys Leu Pro Ile Ala Met Arg 
                245                 250                 255     


Ala Val Thr Asn Tyr Val Cys Leu Lys Asp Ala Tyr Glu Glu Gln Lys 
            260                 265                 270         


Lys Lys Val Ala Asp His Pro Asn Arg Thr Pro Ser Ile Trp Leu Ala 
        275                 280                 285             


Met Tyr Arg Ala Phe Gly Arg Pro Ile Leu Leu Ser Ser Thr Phe Arg 
    290                 295                 300                 


Tyr Leu Ala Asp Leu Leu Gly Phe Ala Gly Pro Leu Cys Ile Ser Gly 
305                 310                 315                 320 


Ile Val Gln Arg Val Asn Glu Thr Gln Asn Gly Thr Asn Asn Thr Thr 
                325                 330                 335     


Gly Ile Ser Glu Thr Leu Ser Ser Lys Glu Phe Leu Glu Asn Ala Tyr 
            340                 345                 350         


Val Leu Ala Val Leu Leu Phe Leu Ala Leu Ile Leu Gln Arg Thr Phe 
        355                 360                 365             


Leu Gln Ala Ser Tyr Tyr Val Thr Ile Glu Thr Gly Ile Asn Leu Arg 
    370                 375                 380                 


Gly Ala Leu Leu Ala Met Ile Tyr Asn Lys Ile Leu Arg Leu Ser Thr 
385                 390                 395                 400 


Ser Asn Leu Ser Met Gly Glu Met Thr Leu Gly Gln Ile Asn Asn Leu 
                405                 410                 415     


Val Ala Ile Glu Thr Asn Gln Leu Met Trp Phe Leu Phe Leu Cys Pro 
            420                 425                 430         


Asn Leu Trp Ala Met Pro Val Gln Ile Ile Met Gly Val Ile Leu Leu 
        435                 440                 445             


Tyr Asn Leu Leu Gly Ser Ser Ala Leu Val Gly Ala Ala Val Ile Val 
    450                 455                 460                 


Leu Leu Ala Pro Ile Gln Tyr Phe Ile Ala Thr Lys Leu Ala Glu Ala 
465                 470                 475                 480 


Gln Lys Ser Thr Leu Asp Tyr Ser Thr Glu Arg Leu Lys Lys Thr Asn 
                485                 490                 495     


Glu Ile Leu Lys Gly Ile Lys Leu Leu Lys Leu Tyr Ala Trp Glu His 
            500                 505                 510         


Ile Phe Cys Lys Ser Val Glu Glu Thr Arg Met Lys Glu Leu Ser Ser 
        515                 520                 525             


Leu Lys Thr Phe Ala Leu Tyr Thr Ser Leu Ser Ile Phe Met Asn Ala 
    530                 535                 540                 


Ala Ile Pro Ile Ala Ala Val Leu Ala Thr Phe Val Thr His Ala Tyr 
545                 550                 555                 560 


Ala Ser Gly Asn Asn Leu Lys Pro Ala Glu Ala Phe Ala Ser Leu Ser 
                565                 570                 575     


Leu Phe His Ile Leu Val Thr Pro Leu Phe Leu Leu Ser Thr Val Val 
            580                 585                 590         


Arg Phe Ala Val Lys Ala Ile Ile Ser Val Gln Lys Leu Asn Glu Phe 
        595                 600                 605             


Leu Leu Ser Asp Glu Ile Gly Asp Asp Ser Trp Arg Thr Gly Glu Ser 
    610                 615                 620                 


Ser Leu Pro Phe Glu Ser Cys Lys Lys His Thr Gly Val Gln Pro Lys 
625                 630                 635                 640 


Thr Ile Asn Arg Lys Gln Pro Gly Arg Tyr His Leu Asp Ser Tyr Glu 
                645                 650                 655     


Gln Ser Thr Arg Arg Leu Arg Pro Ala Glu Thr Glu Asp Ile Ala Ile 
            660                 665                 670         


Lys Val Thr Asn Gly Tyr Phe Ser Trp Gly Ser Gly Leu Ala Thr Leu 
        675                 680                 685             


Ser Asn Ile Asp Ile Arg Ile Pro Thr Gly Gln Leu Thr Met Ile Val 
    690                 695                 700                 


Gly Gln Val Gly Cys Gly Lys Ser Ser Leu Leu Leu Ala Ile Leu Gly 
705                 710                 715                 720 


Glu Met Gln Thr Leu Glu Gly Lys Val His Trp Ser Asn Val Asn Glu 
                725                 730                 735     


Ser Glu Pro Ser Phe Glu Ala Thr Arg Ser Arg Asn Arg Tyr Ser Val 
            740                 745                 750         


Ala Tyr Ala Ala Gln Lys Pro Trp Leu Leu Asn Ala Thr Val Glu Glu 
        755                 760                 765             


Asn Ile Thr Phe Gly Ser Pro Phe Asn Lys Gln Arg Tyr Lys Ala Val 
    770                 775                 780                 


Thr Asp Ala Cys Ser Leu Gln Pro Asp Ile Asp Leu Leu Pro Phe Gly 
785                 790                 795                 800 


Asp Gln Thr Glu Ile Gly Glu Arg Gly Ile Asn Leu Ser Gly Gly Gln 
                805                 810                 815     


Arg Gln Arg Ile Cys Val Ala Arg Ala Leu Tyr Gln Asn Thr Asn Ile 
            820                 825                 830         


Val Phe Leu Asp Asp Pro Phe Ser Ala Leu Asp Ile His Leu Ser Asp 
        835                 840                 845             


His Leu Met Gln Glu Gly Ile Leu Lys Phe Leu Gln Asp Asp Lys Arg 
    850                 855                 860                 


Thr Leu Val Leu Val Thr His Lys Leu Gln Tyr Leu Thr His Ala Asp 
865                 870                 875                 880 


Trp Ile Ile Ala Met Lys Asp Gly Ser Val Leu Arg Glu Gly Thr Leu 
                885                 890                 895     


Lys Asp Ile Gln Thr Lys Asp Val Glu Leu Tyr Glu His Trp Lys Thr 
            900                 905                 910         


Leu Met Asn Arg Gln Asp Gln Glu Leu Glu Lys Asp Met Glu Ala Asp 
        915                 920                 925             


Gln Thr Thr Leu Glu Arg Lys Thr Leu Arg Arg Ala Met Tyr Ser Arg 
    930                 935                 940                 


Glu Ala Lys Ala Gln Met Glu Asp Glu Asp Glu Glu Glu Glu Glu Glu 
945                 950                 955                 960 


Glu Asp Glu Asp Asp Asn Met Ser Thr Val Met Arg Leu Arg Thr Lys 
                965                 970                 975     


Met Pro Trp Lys Thr Cys Trp Arg Tyr Leu Thr Ser Gly Gly Phe Phe 
            980                 985                 990         


Leu Leu Ile Leu Met Ile Phe Ser  Lys Leu Leu Lys His  Ser Val Ile 
        995                 1000                 1005             


Val Ala  Ile Asp Tyr Trp Leu  Ala Thr Trp Thr Ser  Glu Tyr Ser 
    1010                 1015                 1020             


Ile Asn  Asn Thr Gly Lys Ala  Asp Gln Thr Tyr Tyr  Val Ala Gly 
    1025                 1030                 1035             


Phe Ser  Ile Leu Cys Gly Ala  Gly Ile Phe Leu Cys  Leu Val Thr 
    1040                 1045                 1050             


Ser Leu  Thr Val Glu Trp Met  Gly Leu Thr Ala Ala  Lys Asn Leu 
    1055                 1060                 1065             


His His  Asn Leu Leu Asn Lys  Ile Ile Leu Gly Pro  Ile Arg Phe 
    1070                 1075                 1080             


Phe Asp  Thr Thr Pro Leu Gly  Leu Ile Leu Asn Arg  Phe Ser Ala 
    1085                 1090                 1095             


Asp Thr  Asn Ile Ile Asp Gln  His Ile Pro Pro Thr  Leu Glu Ser 
    1100                 1105                 1110             


Leu Thr  Arg Ser Thr Leu Leu  Cys Leu Ser Ala Ile  Gly Met Ile 
    1115                 1120                 1125             


Ser Tyr  Ala Thr Pro Val Phe  Leu Val Ala Leu Leu  Pro Leu Gly 
    1130                 1135                 1140             


Val Ala  Phe Tyr Phe Ile Gln  Lys Tyr Phe Arg Val  Ala Ser Lys 
    1145                 1150                 1155             


Asp Leu  Gln Glu Leu Asp Asp  Ser Thr Gln Leu Pro  Leu Leu Cys 
    1160                 1165                 1170             


His Phe  Ser Glu Thr Ala Glu  Gly Leu Thr Thr Ile  Arg Ala Phe 
    1175                 1180                 1185             


Arg His  Glu Thr Arg Phe Lys  Gln Arg Met Leu Glu  Leu Thr Asp 
    1190                 1195                 1200             


Thr Asn  Asn Ile Ala Tyr Leu  Phe Leu Ser Ala Ala  Asn Arg Trp 
    1205                 1210                 1215             


Leu Glu  Val Arg Thr Asp Tyr  Leu Gly Ala Cys Ile  Val Leu Thr 
    1220                 1225                 1230             


Ala Ser  Ile Ala Ser Ile Ser  Gly Ser Ser Asn Ser  Gly Leu Val 
    1235                 1240                 1245             


Gly Leu  Gly Leu Leu Tyr Ala  Leu Thr Ile Thr Asn  Tyr Leu Asn 
    1250                 1255                 1260             


Trp Val  Val Arg Asn Leu Ala  Asp Leu Glu Val Gln  Met Gly Ala 
    1265                 1270                 1275             


Val Lys  Lys Val Asn Ser Phe  Leu Thr Met Glu Ser  Glu Asn Tyr 
    1280                 1285                 1290             


Glu Gly  Thr Met Asp Pro Ser  Gln Val Pro Glu His  Trp Pro Gln 
    1295                 1300                 1305             


Glu Gly  Glu Ile Lys Ile His  Asp Leu Cys Val Arg  Tyr Glu Asn 
    1310                 1315                 1320             


Asn Leu  Lys Pro Val Leu Lys  His Val Lys Ala Tyr  Ile Lys Pro 
    1325                 1330                 1335             


Gly Gln  Lys Val Gly Ile Cys  Gly Arg Thr Gly Ser  Gly Lys Ser 
    1340                 1345                 1350             


Ser Leu  Ser Leu Ala Phe Phe  Arg Met Val Asp Ile  Phe Asp Gly 
    1355                 1360                 1365             


Lys Ile  Val Ile Asp Gly Ile  Asp Ile Ser Lys Leu  Pro Leu His 
    1370                 1375                 1380             


Thr Leu  Arg Ser Arg Leu Ser  Ile Ile Leu Gln Asp  Pro Ile Leu 
    1385                 1390                 1395             


Phe Ser  Gly Ser Ile Arg Phe  Asn Leu Asp Pro Glu  Cys Lys Cys 
    1400                 1405                 1410             


Thr Asp  Asp Arg Leu Trp Glu  Ala Leu Glu Ile Ala  Gln Leu Lys 
    1415                 1420                 1425             


Asn Met  Val Lys Ser Leu Pro  Gly Gly Leu Asp Ala  Val Val Thr 
    1430                 1435                 1440             


Glu Gly  Gly Glu Asn Phe Ser  Val Gly Gln Arg Gln  Leu Phe Cys 
    1445                 1450                 1455             


Leu Ala  Arg Ala Phe Val Arg  Lys Ser Ser Ile Leu  Ile Met Asp 
    1460                 1465                 1470             


Glu Ala  Thr Ala Ser Ile Asp  Met Ala Thr Glu Asn  Ile Leu Gln 
    1475                 1480                 1485             


Lys Val  Val Met Thr Ala Phe  Ala Asp Arg Thr Val  Val Thr Ile 
    1490                 1495                 1500             


Ala His  Arg Val Ser Ser Ile  Met Asp Ala Gly Leu  Val Leu Val 
    1505                 1510                 1515             


Phe Ser  Glu Gly Ile Leu Val  Glu Cys Asp Thr Val  Pro Asn Leu 
    1520                 1525                 1530             


Leu Ala  His Lys Asn Gly Leu  Phe Ser Thr Leu Val  Met Thr Asn 
    1535                 1540                 1545             


Lys 
    


<210>  3346
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  3346

Met Ser Ala Phe Asp Thr Asn Pro Phe Ala Asp Pro Val Asp Val Asn 
1               5                   10                  15      


Pro Phe Gln Asp Pro Ser Val Thr Gln Leu Thr Asn Ala Pro Gln Gly 
            20                  25                  30          


Gly Leu Ala Glu Phe Asn Pro Phe Ser Glu Thr Asn Ala Ala Thr Thr 
        35                  40                  45              


Val Pro Val Thr Gln Leu Pro Gly Ser Ser Gln Pro Ala Val Leu Gln 
    50                  55                  60                  


Pro Ser Val Glu Pro Thr Gln Pro Thr Pro Gln Ala Val Val Ser Ala 
65                  70                  75                  80  


Ala Gln Ala Gly Leu Leu Arg Gln Gln Glu Glu Leu Asp Arg Lys Ala 
                85                  90                  95      


Ala Glu Leu Glu Arg Lys Glu Arg Glu Leu Gln Asn Thr Val Ala Asn 
            100                 105                 110         


Leu His Val Arg Gln Asn Asn Trp Pro Pro Leu Pro Ser Trp Cys Pro 
        115                 120                 125             


Val Lys Pro Cys Phe Tyr Gln Asp Phe Ser Thr Glu Ile Pro Ala Asp 
    130                 135                 140                 


Tyr Gln Arg Ile Cys Lys Met Leu Tyr Tyr Leu Trp Met Leu His Ser 
145                 150                 155                 160 


Val Thr Leu Phe Leu Asn Leu Leu Ala Cys Leu Ala Trp Phe Ser Gly 
                165                 170                 175     


Asn Ser Ser Lys Gly Val Asp Phe Gly Leu Ser Ile Leu Trp Phe Leu 
            180                 185                 190         


Ile Phe Thr Pro Cys Ala Phe Leu Cys Trp Tyr Arg Pro Ile Tyr Lys 
        195                 200                 205             


Ala Phe Arg Ser Asp Asn Ser Phe Ser Phe Phe Val Phe Phe Phe Val 
    210                 215                 220                 


Phe Phe Cys Gln Ile Gly Ile Tyr Ile Ile Gln Leu Val Gly Ile Pro 
225                 230                 235                 240 


Gly Leu Gly Asp Ser Gly Trp Ile Ala Ala Leu Ser Thr Leu Asp Asn 
                245                 250                 255     


His Ser Leu Ala Ile Ser Val Ile Met Met Val Val Ala Gly Phe Phe 
            260                 265                 270         


Thr Leu Cys Ala Val Leu Ser Val Phe Leu Leu Gln Arg Val His Ser 
        275                 280                 285             


Leu Tyr Arg Arg Thr Gly Ala Ser Phe Gln Gln Ala Gln Glu Glu Phe 
    290                 295                 300                 


Ser Gln Gly Ile Phe Ser Ser Arg Thr Phe His Arg Ala Ala Ser Ser 
305                 310                 315                 320 


Ala Ala Gln Gly Ala Phe Gln Gly Asn 
                325                 


<210>  3347
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  3347

Met Ala Gln Ser Arg Asp Gly Gly Asn Pro Phe Ala Glu Pro Ser Glu 
1               5                   10                  15      


Leu Asp Asn Pro Phe Gln Asp Pro Ala Val Ile Gln His Arg Pro Ser 
            20                  25                  30          


Arg Gln Tyr Ala Thr Leu Asp Val Tyr Asn Pro Phe Glu Thr Arg Glu 
        35                  40                  45              


Pro Pro Pro Ala Tyr Glu Pro Pro Ala Pro Ala Pro Leu Pro Pro Pro 
    50                  55                  60                  


Ser Ala Pro Ser Leu Gln Pro Ser Arg Lys Leu Ser Pro Thr Glu Pro 
65                  70                  75                  80  


Lys Asn Tyr Gly Ser Tyr Ser Thr Gln Ala Ser Ala Ala Ala Ala Thr 
                85                  90                  95      


Ala Glu Leu Leu Lys Lys Gln Glu Glu Leu Asn Arg Lys Ala Glu Glu 
            100                 105                 110         


Leu Asp Arg Arg Glu Arg Glu Leu Gln His Ala Ala Leu Gly Gly Thr 
        115                 120                 125             


Ala Thr Arg Gln Asn Asn Trp Pro Pro Leu Pro Ser Phe Cys Pro Val 
    130                 135                 140                 


Gln Pro Cys Phe Phe Gln Asp Ile Ser Met Glu Ile Pro Gln Glu Phe 
145                 150                 155                 160 


Gln Lys Thr Val Ser Thr Met Tyr Tyr Leu Trp Met Cys Ser Thr Leu 
                165                 170                 175     


Ala Leu Leu Leu Asn Phe Leu Ala Cys Leu Ala Ser Phe Cys Val Glu 
            180                 185                 190         


Thr Asn Asn Gly Ala Gly Phe Gly Leu Ser Ile Leu Trp Val Leu Leu 
        195                 200                 205             


Phe Thr Pro Cys Ser Phe Val Cys Trp Tyr Arg Pro Met Tyr Lys Ala 
    210                 215                 220                 


Phe Arg Ser Asp Ser Ser Phe Asn Phe Phe Val Phe Phe Phe Ile Phe 
225                 230                 235                 240 


Phe Val Gln Asp Val Leu Phe Val Leu Gln Ala Ile Gly Ile Pro Gly 
                245                 250                 255     


Trp Gly Phe Ser Gly Trp Ile Ser Ala Leu Val Val Pro Lys Gly Asn 
            260                 265                 270         


Thr Ala Val Ser Val Leu Met Leu Leu Val Ala Leu Leu Phe Thr Gly 
        275                 280                 285             


Ile Ala Val Leu Gly Ile Val Met Leu Lys Arg Ile His Ser Leu Tyr 
    290                 295                 300                 


Arg Arg Thr Gly Ala Ser Phe Gln Lys Ala Gln Gln Glu Phe Ala Ala 
305                 310                 315                 320 


Gly Val Phe Ser Asn Pro Ala Val Arg Thr Ala Ala Ala Asn Ala Ala 
                325                 330                 335     


Ala Gly Ala Ala Glu Asn Ala Phe Arg Ala Pro 
            340                 345         


<210>  3348
<211>  1446
<212>  PRT
<213>  Homo sapiens

<400>  3348

Met Ala Arg Ala Gln Ala Leu Val Leu Ala Leu Thr Phe Gln Leu Cys 
1               5                   10                  15      


Ala Pro Glu Thr Glu Thr Pro Ala Ala Gly Cys Thr Phe Glu Glu Ala 
            20                  25                  30          


Ser Asp Pro Ala Val Pro Cys Glu Tyr Ser Gln Ala Gln Tyr Asp Asp 
        35                  40                  45              


Phe Gln Trp Glu Gln Val Arg Ile His Pro Gly Thr Arg Ala Pro Ala 
    50                  55                  60                  


Asp Leu Pro His Gly Ser Tyr Leu Met Val Asn Thr Ser Gln His Ala 
65                  70                  75                  80  


Pro Gly Gln Arg Ala His Val Ile Phe Gln Ser Leu Ser Glu Asn Asp 
                85                  90                  95      


Thr His Cys Val Gln Phe Ser Tyr Phe Leu Tyr Ser Arg Asp Gly His 
            100                 105                 110         


Ser Pro Gly Thr Leu Gly Val Tyr Val Arg Val Asn Gly Gly Pro Leu 
        115                 120                 125             


Gly Ser Ala Val Trp Asn Met Thr Gly Ser His Gly Arg Gln Trp His 
    130                 135                 140                 


Gln Ala Glu Leu Ala Val Ser Thr Phe Trp Pro Asn Glu Tyr Gln Val 
145                 150                 155                 160 


Leu Phe Glu Ala Leu Ile Ser Pro Asp Arg Arg Gly Tyr Met Gly Leu 
                165                 170                 175     


Asp Asp Ile Leu Leu Leu Ser Tyr Pro Cys Ala Lys Ala Pro His Phe 
            180                 185                 190         


Ser Arg Leu Gly Asp Val Glu Val Asn Ala Gly Gln Asn Ala Ser Phe 
        195                 200                 205             


Gln Cys Met Ala Ala Gly Arg Ala Ala Glu Ala Glu Arg Phe Leu Leu 
    210                 215                 220                 


Gln Arg Gln Ser Gly Ala Leu Val Pro Ala Ala Gly Val Arg His Ile 
225                 230                 235                 240 


Ser His Arg Arg Phe Leu Ala Thr Phe Pro Leu Ala Ala Val Ser Arg 
                245                 250                 255     


Ala Glu Gln Asp Leu Tyr Arg Cys Val Ser Gln Ala Pro Arg Gly Ala 
            260                 265                 270         


Gly Val Ser Asn Phe Ala Glu Leu Ile Val Lys Glu Pro Pro Thr Pro 
        275                 280                 285             


Ile Ala Pro Pro Gln Leu Leu Arg Ala Gly Pro Thr Tyr Leu Ile Ile 
    290                 295                 300                 


Gln Leu Asn Thr Asn Ser Ile Ile Gly Asp Gly Pro Ile Val Arg Lys 
305                 310                 315                 320 


Glu Ile Glu Tyr Arg Met Ala Arg Gly Pro Trp Ala Glu Val His Ala 
                325                 330                 335     


Val Ser Leu Gln Thr Tyr Lys Leu Trp His Leu Asp Pro Asp Thr Glu 
            340                 345                 350         


Tyr Glu Ile Ser Val Leu Leu Thr Arg Pro Gly Asp Gly Gly Thr Gly 
        355                 360                 365             


Arg Pro Gly Pro Pro Leu Ile Ser Arg Thr Lys Cys Ala Glu Pro Met 
    370                 375                 380                 


Arg Ala Pro Lys Gly Leu Ala Phe Ala Glu Ile Gln Ala Arg Gln Leu 
385                 390                 395                 400 


Thr Leu Gln Trp Glu Pro Leu Gly Tyr Asn Val Thr Arg Cys His Thr 
                405                 410                 415     


Tyr Thr Val Ser Leu Cys Tyr His Tyr Thr Leu Gly Ser Ser His Asn 
            420                 425                 430         


Gln Thr Ile Arg Glu Cys Val Lys Thr Glu Gln Gly Val Ser Arg Tyr 
        435                 440                 445             


Thr Ile Lys Asn Leu Leu Pro Tyr Arg Asn Val His Val Arg Leu Val 
    450                 455                 460                 


Leu Thr Asn Pro Glu Gly Arg Lys Glu Gly Lys Glu Val Thr Phe Gln 
465                 470                 475                 480 


Thr Asp Glu Asp Val Pro Ser Gly Ile Ala Ala Glu Ser Leu Thr Phe 
                485                 490                 495     


Thr Pro Leu Glu Asp Met Ile Phe Leu Lys Trp Glu Glu Pro Gln Glu 
            500                 505                 510         


Pro Asn Gly Leu Ile Thr Gln Tyr Glu Ile Ser Tyr Gln Ser Ile Glu 
        515                 520                 525             


Ser Ser Asp Pro Ala Val Asn Val Pro Gly Pro Arg Arg Thr Ile Ser 
    530                 535                 540                 


Lys Leu Arg Asn Glu Thr Tyr His Val Phe Ser Asn Leu His Pro Gly 
545                 550                 555                 560 


Thr Thr Tyr Leu Phe Ser Val Arg Ala Arg Thr Gly Lys Gly Phe Gly 
                565                 570                 575     


Gln Ala Ala Leu Thr Glu Ile Thr Thr Asn Ile Ser Ala Pro Ser Phe 
            580                 585                 590         


Asp Tyr Ala Asp Met Pro Ser Pro Leu Gly Glu Ser Glu Asn Thr Ile 
        595                 600                 605             


Thr Val Leu Leu Arg Pro Ala Gln Gly Arg Gly Ala Pro Ile Ser Val 
    610                 615                 620                 


Tyr Gln Val Ile Val Glu Glu Glu Arg Ala Arg Arg Leu Arg Arg Glu 
625                 630                 635                 640 


Pro Gly Gly Gln Asp Cys Phe Pro Val Pro Leu Thr Phe Glu Ala Ala 
                645                 650                 655     


Leu Ala Arg Gly Leu Val His Tyr Phe Gly Ala Glu Leu Ala Ala Ser 
            660                 665                 670         


Ser Leu Pro Glu Ala Met Pro Phe Thr Val Gly Asp Asn Gln Thr Tyr 
        675                 680                 685             


Arg Gly Phe Trp Asn Pro Pro Leu Glu Pro Arg Lys Ala Tyr Leu Ile 
    690                 695                 700                 


Tyr Phe Gln Ala Ala Ser His Leu Lys Gly Glu Thr Arg Leu Asn Cys 
705                 710                 715                 720 


Ile Arg Ile Ala Arg Lys Ala Ala Cys Lys Glu Ser Lys Arg Pro Leu 
                725                 730                 735     


Glu Val Ser Gln Arg Ser Glu Glu Met Gly Leu Ile Leu Gly Ile Cys 
            740                 745                 750         


Ala Gly Gly Leu Ala Val Leu Ile Leu Leu Leu Gly Ala Ile Ile Val 
        755                 760                 765             


Ile Ile Arg Lys Gly Arg Asp His Tyr Ala Tyr Ser Tyr Tyr Pro Lys 
    770                 775                 780                 


Pro Val Asn Met Thr Lys Ala Thr Val Asn Tyr Arg Gln Glu Lys Thr 
785                 790                 795                 800 


His Met Met Ser Ala Val Asp Arg Ser Phe Thr Asp Gln Ser Thr Leu 
                805                 810                 815     


Gln Glu Asp Glu Arg Leu Gly Leu Ser Phe Met Asp Thr His Gly Tyr 
            820                 825                 830         


Ser Thr Arg Gly Asp Gln Arg Ser Gly Gly Val Thr Glu Ala Ser Ser 
        835                 840                 845             


Leu Leu Gly Gly Ser Pro Arg Arg Pro Cys Gly Arg Lys Gly Ser Pro 
    850                 855                 860                 


Tyr His Thr Gly Gln Leu His Pro Ala Val Arg Val Ala Asp Leu Leu 
865                 870                 875                 880 


Gln His Ile Asn Gln Met Lys Thr Ala Glu Gly Tyr Gly Phe Lys Gln 
                885                 890                 895     


Glu Tyr Glu Ser Phe Phe Glu Gly Trp Asp Ala Thr Lys Lys Lys Asp 
            900                 905                 910         


Lys Val Lys Gly Ser Arg Gln Glu Pro Met Pro Ala Tyr Asp Arg His 
        915                 920                 925             


Arg Val Lys Leu His Pro Met Leu Gly Asp Pro Asn Ala Asp Tyr Ile 
    930                 935                 940                 


Asn Ala Asn Tyr Ile Asp Gly Tyr His Arg Ser Asn His Phe Ile Ala 
945                 950                 955                 960 


Thr Gln Gly Pro Lys Pro Glu Met Val Tyr Asp Phe Trp Arg Met Val 
                965                 970                 975     


Trp Gln Glu His Cys Ser Ser Ile Val Met Ile Thr Lys Leu Val Glu 
            980                 985                 990         


Val Gly Arg Val Lys Cys Ser Arg  Tyr Trp Pro Glu Asp  Ser Asp Thr 
        995                 1000                 1005             


Tyr Gly  Asp Ile Lys Ile Met  Leu Val Lys Thr Glu  Thr Leu Ala 
    1010                 1015                 1020             


Glu Tyr  Val Val Arg Thr Phe  Ala Leu Glu Arg Arg  Gly Tyr Ser 
    1025                 1030                 1035             


Ala Arg  His Glu Val Arg Gln  Phe His Phe Thr Ala  Trp Pro Glu 
    1040                 1045                 1050             


His Gly  Val Pro Tyr His Ala  Thr Gly Leu Leu Ala  Phe Ile Arg 
    1055                 1060                 1065             


Arg Val  Lys Ala Ser Thr Pro  Pro Asp Ala Gly Pro  Ile Val Ile 
    1070                 1075                 1080             


His Cys  Ser Ala Gly Thr Gly  Arg Thr Gly Cys Tyr  Ile Val Leu 
    1085                 1090                 1095             


Asp Val  Met Leu Asp Met Ala  Glu Cys Glu Gly Val  Val Asp Ile 
    1100                 1105                 1110             


Tyr Asn  Cys Val Lys Thr Leu  Cys Ser Arg Arg Val  Asn Met Ile 
    1115                 1120                 1125             


Gln Thr  Glu Glu Gln Tyr Ile  Phe Ile His Asp Ala  Ile Leu Glu 
    1130                 1135                 1140             


Ala Cys  Leu Cys Gly Glu Thr  Thr Ile Pro Val Ser  Glu Phe Lys 
    1145                 1150                 1155             


Ala Thr  Tyr Lys Glu Met Ile  Arg Ile Asp Pro Gln  Ser Asn Ser 
    1160                 1165                 1170             


Ser Gln  Leu Arg Glu Glu Phe  Gln Thr Leu Asn Ser  Val Thr Pro 
    1175                 1180                 1185             


Pro Leu  Asp Val Glu Glu Cys  Ser Ile Ala Leu Leu  Pro Arg Asn 
    1190                 1195                 1200             


Arg Asp  Lys Asn Arg Ser Met  Asp Val Leu Pro Pro  Asp Arg Cys 
    1205                 1210                 1215             


Leu Pro  Phe Leu Ile Ser Thr  Asp Gly Asp Ser Asn  Asn Tyr Ile 
    1220                 1225                 1230             


Asn Ala  Ala Leu Thr Asp Ser  Tyr Thr Arg Ser Ala  Ala Phe Ile 
    1235                 1240                 1245             


Val Thr  Leu His Pro Leu Gln  Ser Thr Thr Pro Asp  Phe Trp Arg 
    1250                 1255                 1260             


Leu Val  Tyr Asp Tyr Gly Cys  Thr Ser Ile Val Met  Leu Asn Gln 
    1265                 1270                 1275             


Leu Asn  Gln Ser Asn Ser Ala  Trp Pro Cys Leu Gln  Tyr Trp Pro 
    1280                 1285                 1290             


Glu Pro  Gly Arg Gln Gln Tyr  Gly Leu Met Glu Val  Glu Phe Met 
    1295                 1300                 1305             


Ser Gly  Thr Ala Asp Glu Asp  Leu Val Ala Arg Val  Phe Arg Val 
    1310                 1315                 1320             


Gln Asn  Ile Ser Arg Leu Gln  Glu Gly His Leu Leu  Val Arg His 
    1325                 1330                 1335             


Phe Gln  Phe Leu Arg Trp Ser  Ala Tyr Arg Asp Thr  Pro Asp Ser 
    1340                 1345                 1350             


Lys Lys  Ala Phe Leu His Leu  Leu Ala Glu Val Asp  Lys Trp Gln 
    1355                 1360                 1365             


Ala Glu  Ser Gly Asp Gly Arg  Thr Ile Val His Cys  Leu Asn Gly 
    1370                 1375                 1380             


Gly Gly  Arg Ser Gly Thr Phe  Cys Ala Cys Ala Thr  Val Leu Glu 
    1385                 1390                 1395             


Met Ile  Arg Cys His Asn Leu  Val Asp Val Phe Phe  Ala Ala Lys 
    1400                 1405                 1410             


Thr Leu  Arg Asn Tyr Lys Pro  Asn Met Val Glu Thr  Met Asp Gln 
    1415                 1420                 1425             


Tyr His  Phe Cys Tyr Asp Val  Ala Leu Glu Tyr Leu  Glu Gly Leu 
    1430                 1435                 1440             


Glu Ser  Arg 
    1445     


<210>  3349
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  3349

Met Gly Gly Leu Arg Pro Trp Ser Arg Tyr Gly Leu Leu Val Val Ala 
1               5                   10                  15      


His Leu Leu Ala Leu Gly Leu Gly Ala Val Val Phe Gln Ala Leu Glu 
            20                  25                  30          


Gly Pro Pro Ala Cys Arg Leu Gln Ala Glu Leu Arg Ala Glu Leu Ala 
        35                  40                  45              


Ala Phe Gln Ala Glu His Arg Ala Cys Leu Pro Pro Gly Ala Leu Glu 
    50                  55                  60                  


Glu Leu Leu Gly Thr Ala Leu Ala Thr Gln Ala His Gly Val Ser Thr 
65                  70                  75                  80  


Leu Gly Asn Ser Ser Glu Gly Arg Thr Trp Asp Leu Pro Ser Ala Leu 
                85                  90                  95      


Leu Phe Ala Ala Ser Ile Leu Thr Thr Thr Gly Tyr Gly His Met Ala 
            100                 105                 110         


Pro Leu Ser Pro Gly Gly Lys Ala Phe Cys Met Val Tyr Ala Ala Leu 
        115                 120                 125             


Gly Leu Pro Ala Ser Leu Ala Leu Val Ala Thr Leu Arg His Cys Leu 
    130                 135                 140                 


Leu Pro Val Leu Ser Arg Pro Arg Ala Trp Val Ala Val His Trp Gln 
145                 150                 155                 160 


Leu Ser Pro Ala Arg Ala Ala Leu Leu Gln Ala Val Ala Leu Gly Leu 
                165                 170                 175     


Leu Val Ala Ser Ser Phe Val Leu Leu Pro Ala Leu Val Leu Trp Gly 
            180                 185                 190         


Leu Gln Gly Asp Cys Ser Leu Leu Gly Ala Val Tyr Phe Cys Phe Ser 
        195                 200                 205             


Ser Leu Ser Thr Ile Gly Leu Glu Asp Leu Leu Pro Gly Arg Gly Arg 
    210                 215                 220                 


Ser Leu His Pro Val Ile Tyr His Leu Gly Gln Leu Ala Leu Leu Gly 
225                 230                 235                 240 


Lys Ser Ser His Leu Thr Ala Cys Gly Gly Arg Gly Lys Arg Ser Leu 
                245                 250                 255     


Asp 
    


<210>  3350
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  3350

Met Lys Lys Lys Gln Gln His Pro Gly Gly Gly Ala Asp Pro Trp Pro 
1               5                   10                  15      


His Gly Ala Pro Met Gly Gly Ala Pro Pro Gly Leu Gly Ser Trp Lys 
            20                  25                  30          


Arg Arg Val Pro Leu Leu Pro Phe Leu Arg Phe Ser Leu Arg Asp Tyr 
        35                  40                  45              


Gly Phe Cys Met Ala Thr Leu Leu Val Phe Cys Leu Gly Ser Leu Leu 
    50                  55                  60                  


Tyr Gln Leu Ser Gly Gly Pro Pro Arg Phe Leu Leu Asp Leu Arg Gln 
65                  70                  75                  80  


Tyr Leu Gly Asn Ser Thr Tyr Leu Asp Asp His Gly Pro Pro Pro Ser 
                85                  90                  95      


Lys Val Leu Pro Phe Pro Ser Gln Val Val Tyr Asn Arg Val Gly Lys 
            100                 105                 110         


Cys Gly Ser Arg Thr Val Val Leu Leu Leu Arg Ile Leu Ser Glu Lys 
        115                 120                 125             


His Gly Phe Asn Leu Val Thr Ser Asp Ile His Asn Lys Thr Arg Leu 
    130                 135                 140                 


Thr Lys Asn Glu Gln Met Glu Leu Ile Lys Asn Ile Ser Thr Ala Glu 
145                 150                 155                 160 


Gln Pro Tyr Leu Phe Thr Arg His Val His Phe Leu Asn Phe Ser Arg 
                165                 170                 175     


Phe Gly Gly Asp Gln Pro Val Tyr Ile Asn Ile Ile Arg Asp Pro Val 
            180                 185                 190         


Asn Arg Phe Leu Ser Asn Tyr Phe Phe Arg Arg Phe Gly Asp Trp Arg 
        195                 200                 205             


Gly Glu Gln Asn His Met Ile Arg Thr Pro Ser Met Arg Gln Glu Glu 
    210                 215                 220                 


Arg Tyr Leu Asp Ile Asn Glu Cys Ile Leu Glu Asn Tyr Pro Glu Cys 
225                 230                 235                 240 


Ser Asn Pro Arg Leu Phe Tyr Ile Ile Pro Tyr Phe Cys Gly Gln His 
                245                 250                 255     


Pro Arg Cys Arg Glu Pro Gly Glu Trp Ala Leu Glu Arg Ala Lys Leu 
            260                 265                 270         


Asn Val Asn Glu Asn Phe Leu Leu Val Gly Ile Leu Glu Glu Leu Glu 
        275                 280                 285             


Asp Val Leu Leu Leu Leu Glu Arg Phe Leu Pro His Tyr Phe Lys Gly 
    290                 295                 300                 


Val Leu Ser Ile Tyr Lys Asp Pro Glu His Arg Lys Leu Gly Asn Met 
305                 310                 315                 320 


Thr Val Thr Val Lys Lys Thr Val Pro Ser Pro Glu Ala Val Gln Ile 
                325                 330                 335     


Leu Tyr Gln Arg Met Arg Tyr Glu Tyr Glu Phe Tyr His Tyr Val Lys 
            340                 345                 350         


Glu Gln Phe His Leu Leu Lys Arg Lys Phe Gly Leu Lys Ser His Val 
        355                 360                 365             


Ser Lys Pro Pro Leu Arg Pro His Phe Phe Ile Pro Thr Pro Leu Glu 
    370                 375                 380                 


Thr Glu Glu Pro Ile Asp Asp Glu Glu Gln Asp Asp Glu Lys Trp Leu 
385                 390                 395                 400 


Glu Asp Ile Tyr Lys Arg 
                405     


<210>  3351
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  3351

Met Ser Gly Lys His Tyr Lys Gly Pro Glu Val Ser Cys Cys Ile Lys 
1               5                   10                  15      


Tyr Phe Ile Phe Gly Phe Asn Val Ile Phe Trp Phe Leu Gly Ile Thr 
            20                  25                  30          


Phe Leu Gly Ile Gly Leu Trp Ala Trp Asn Glu Lys Gly Val Leu Ser 
        35                  40                  45              


Asn Ile Ser Ser Ile Thr Asp Leu Gly Gly Phe Asp Pro Val Trp Leu 
    50                  55                  60                  


Phe Leu Val Val Gly Gly Val Met Phe Ile Leu Gly Phe Ala Gly Cys 
65                  70                  75                  80  


Ile Gly Ala Leu Arg Glu Asn Thr Phe Leu Leu Lys Phe Phe Ser Val 
                85                  90                  95      


Phe Leu Gly Ile Ile Phe Phe Leu Glu Leu Thr Ala Gly Val Leu Ala 
            100                 105                 110         


Phe Val Phe Lys Asp Trp Ile Lys Asp Gln Leu Tyr Phe Phe Ile Asn 
        115                 120                 125             


Asn Asn Ile Arg Ala Tyr Arg Asp Asp Ile Asp Leu Gln Asn Leu Ile 
    130                 135                 140                 


Asp Phe Thr Gln Glu Tyr Trp Gln Cys Cys Gly Ala Phe Gly Ala Asp 
145                 150                 155                 160 


Asp Trp Asn Leu Asn Ile Tyr Phe Asn Cys Thr Asp Ser Asn Ala Ser 
                165                 170                 175     


Arg Glu Arg Cys Gly Val Pro Phe Ser Cys Cys Thr Lys Asp Pro Ala 
            180                 185                 190         


Glu Asp Val Ile Asn Thr Gln Cys Gly Tyr Asp Ala Arg Gln Lys Pro 
        195                 200                 205             


Glu Val Asp Gln Gln Ile Val Ile Tyr Thr Lys Gly Cys Val Pro Gln 
    210                 215                 220                 


Phe Glu Lys Trp Leu Gln Asp Asn Leu Thr Ile Val Ala Gly Ile Phe 
225                 230                 235                 240 


Ile Gly Ile Ala Leu Leu Gln Ile Phe Gly Ile Cys Leu Ala Gln Asn 
                245                 250                 255     


Leu Val Ser Asp Ile Glu Ala Val Arg Ala Ser Trp 
            260                 265             


<210>  3352
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  3352

Met Gly Gln Cys Gly Ile Thr Ser Ser Lys Thr Val Leu Val Phe Leu 
1               5                   10                  15      


Asn Leu Ile Phe Trp Gly Ala Ala Gly Ile Leu Cys Tyr Val Gly Ala 
            20                  25                  30          


Tyr Val Phe Ile Thr Tyr Asp Asp Tyr Asp His Phe Phe Glu Asp Val 
        35                  40                  45              


Tyr Thr Leu Ile Pro Ala Val Val Ile Ile Ala Val Gly Ala Leu Leu 
    50                  55                  60                  


Phe Ile Ile Gly Leu Ile Gly Cys Cys Ala Thr Ile Arg Glu Ser Arg 
65                  70                  75                  80  


Cys Gly Leu Ala Thr Phe Val Ile Ile Leu Leu Leu Val Phe Val Thr 
                85                  90                  95      


Glu Val Val Val Val Val Leu Gly Tyr Val Tyr Arg Ala Lys Val Glu 
            100                 105                 110         


Asn Glu Val Asp Arg Ser Ile Gln Lys Val Tyr Lys Thr Tyr Asn Gly 
        115                 120                 125             


Thr Asn Pro Asp Ala Ala Ser Arg Ala Ile Asp Tyr Val Gln Arg Gln 
    130                 135                 140                 


Leu His Cys Cys Gly Ile His Asn Tyr Ser Asp Trp Glu Asn Thr Asp 
145                 150                 155                 160 


Trp Phe Lys Glu Thr Lys Asn Gln Ser Val Pro Leu Ser Cys Cys Arg 
                165                 170                 175     


Glu Thr Ala Ser Asn Cys Asn Gly Ser Leu Ala His Pro Ser Asp Leu 
            180                 185                 190         


Tyr Ala Glu Gly Cys Glu Ala Leu Val Val Lys Lys Leu Gln Glu Ile 
        195                 200                 205             


Met Met His Val Ile Trp Ala Ala Leu Ala Phe Ala Ala Ile Gln Leu 
    210                 215                 220                 


Leu Gly Met Leu Cys Ala Cys Ile Val Leu Cys Arg Arg Ser Arg Asp 
225                 230                 235                 240 


Pro Ala Tyr Glu Leu Leu Ile Thr Gly Gly Thr Tyr Ala 
                245                 250             


<210>  3353
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  3353

Met Gly Arg Phe Arg Gly Gly Leu Arg Cys Ile Lys Tyr Leu Leu Leu 
1               5                   10                  15      


Gly Phe Asn Leu Leu Phe Trp Leu Ala Gly Ser Ala Val Ile Ala Phe 
            20                  25                  30          


Gly Leu Trp Phe Arg Phe Gly Gly Ala Ile Lys Glu Leu Ser Ser Glu 
        35                  40                  45              


Asp Lys Ser Pro Glu Tyr Phe Tyr Val Gly Leu Tyr Val Leu Val Gly 
    50                  55                  60                  


Ala Gly Ala Leu Met Met Ala Val Gly Phe Phe Gly Cys Cys Gly Ala 
65                  70                  75                  80  


Met Arg Glu Ser Gln Cys Val Leu Gly Ser Phe Phe Thr Cys Leu Leu 
                85                  90                  95      


Val Ile Phe Ala Ala Glu Val Thr Thr Gly Val Phe Ala Phe Ile Gly 
            100                 105                 110         


Lys Gly Val Ala Ile Arg His Val Gln Thr Met Tyr Glu Glu Ala Tyr 
        115                 120                 125             


Asn Asp Tyr Leu Lys Asp Arg Gly Lys Gly Asn Gly Thr Leu Ile Thr 
    130                 135                 140                 


Phe His Ser Thr Phe Gln Cys Cys Gly Lys Glu Ser Ser Glu Gln Val 
145                 150                 155                 160 


Gln Pro Thr Cys Pro Lys Glu Leu Leu Gly His Lys Asn Cys Ile Asp 
                165                 170                 175     


Glu Ile Glu Thr Ile Ile Ser Val Lys Leu Gln Leu Ile Gly Ile Val 
            180                 185                 190         


Gly Ile Gly Ile Ala Gly Leu Thr Ile Phe Gly Met Ile Phe Ser Met 
        195                 200                 205             


Val Leu Cys Cys Ala Ile Arg Asn Ser Arg Asp Val Ile 
    210                 215                 220     


<210>  3354
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  3354

Met Gln Cys Phe Ser Phe Ile Lys Thr Met Met Ile Leu Phe Asn Leu 
1               5                   10                  15      


Leu Ile Phe Leu Cys Gly Ala Ala Leu Leu Ala Val Gly Ile Trp Val 
            20                  25                  30          


Ser Ile Asp Gly Ala Ser Phe Leu Lys Ile Phe Gly Pro Leu Ser Ser 
        35                  40                  45              


Ser Ala Met Gln Phe Val Asn Val Gly Tyr Phe Leu Ile Ala Ala Gly 
    50                  55                  60                  


Val Val Val Phe Ala Leu Gly Phe Leu Gly Cys Tyr Gly Ala Lys Thr 
65                  70                  75                  80  


Glu Ser Lys Cys Ala Leu Val Thr Phe Phe Phe Ile Leu Leu Leu Ile 
                85                  90                  95      


Phe Ile Ala Glu Val Ala Ala Ala Val Val Ala Leu Val Tyr Thr Thr 
            100                 105                 110         


Met Ala Glu His Phe Leu Thr Leu Leu Val Val Pro Ala Ile Lys Lys 
        115                 120                 125             


Asp Tyr Gly Ser Gln Glu Asp Phe Thr Gln Val Trp Asn Thr Thr Met 
    130                 135                 140                 


Lys Gly Leu Lys Cys Cys Gly Phe Thr Asn Tyr Thr Asp Phe Glu Asp 
145                 150                 155                 160 


Ser Pro Tyr Phe Lys Glu Asn Ser Ala Phe Pro Pro Phe Cys Cys Asn 
                165                 170                 175     


Asp Asn Val Thr Asn Thr Ala Asn Glu Thr Cys Thr Lys Gln Lys Ala 
            180                 185                 190         


His Asp Gln Lys Val Glu Gly Cys Phe Asn Gln Leu Leu Tyr Asp Ile 
        195                 200                 205             


Arg Thr Asn Ala Val Thr Val Gly Gly Val Ala Ala Gly Ile Gly Gly 
    210                 215                 220                 


Leu Glu Leu Ala Ala Met Ile Val Ser Met Tyr Leu Tyr Cys Asn Leu 
225                 230                 235                 240 


Gln 
    


<210>  3355
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  3355

Met Ser Leu Gln Trp Thr Ala Val Ala Thr Phe Leu Tyr Ala Glu Val 
1               5                   10                  15      


Phe Val Val Leu Leu Leu Cys Ile Pro Phe Ile Ser Pro Lys Arg Trp 
            20                  25                  30          


Gln Lys Ile Phe Lys Ser Arg Leu Val Glu Leu Leu Val Ser Tyr Gly 
        35                  40                  45              


Asn Thr Phe Phe Val Val Leu Ile Val Ile Leu Val Leu Leu Val Ile 
    50                  55                  60                  


Asp Ala Val Arg Glu Ile Arg Lys Tyr Asp Asp Val Thr Glu Lys Val 
65                  70                  75                  80  


Asn Leu Gln Asn Asn Pro Gly Ala Met Glu His Phe His Met Lys Leu 
                85                  90                  95      


Phe Arg Ala Gln Arg Asn Leu Tyr Ile Ala Gly Phe Ser Leu Leu Leu 
            100                 105                 110         


Ser Phe Leu Leu Arg Arg Leu Val Thr Leu Ile Ser Gln Gln Ala Thr 
        115                 120                 125             


Leu Leu Ala Ser Asn Glu Ala Phe Lys Lys Gln Ala Glu Ser Ala Ser 
    130                 135                 140                 


Glu Ala Ala Lys Lys Tyr Met Glu Glu Asn Asp Gln Leu Lys Lys Gly 
145                 150                 155                 160 


Ala Ala Val Asp Gly Gly Lys Leu Asp Val Gly Asn Ala Glu Val Lys 
                165                 170                 175     


Leu Glu Glu Glu Asn Arg Ser Leu Lys Ala Asp Leu Gln Lys Leu Lys 
            180                 185                 190         


Asp Glu Leu Ala Ser Thr Lys Gln Lys Leu Glu Lys Ala Glu Asn Gln 
        195                 200                 205             


Val Leu Ala Met Arg Lys Gln Ser Glu Gly Leu Thr Lys Glu Tyr Asp 
    210                 215                 220                 


Arg Leu Leu Glu Glu His Ala Lys Leu Gln Ala Ala Val Asp Gly Pro 
225                 230                 235                 240 


Met Asp Lys Lys Glu Glu 
                245     


<210>  3356
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  3356

Met Ala Gln Gln Ala Cys Pro Arg Ala Met Ala Lys Asn Gly Leu Val 
1               5                   10                  15      


Ile Cys Ile Leu Val Ile Thr Leu Leu Leu Asp Gln Thr Thr Ser His 
            20                  25                  30          


Thr Ser Arg Leu Lys Ala Arg Lys His Ser Lys Arg Arg Val Arg Asp 
        35                  40                  45              


Lys Asp Gly Asp Leu Lys Thr Gln Ile Glu Lys Leu Trp Thr Glu Val 
    50                  55                  60                  


Asn Ala Leu Lys Glu Ile Gln Ala Leu Gln Thr Val Cys Leu Arg Gly 
65                  70                  75                  80  


Thr Lys Val His Lys Lys Cys Tyr Leu Ala Ser Glu Gly Leu Lys His 
                85                  90                  95      


Phe His Glu Ala Asn Glu Asp Cys Ile Ser Lys Gly Gly Ile Leu Val 
            100                 105                 110         


Ile Pro Arg Asn Ser Asp Glu Ile Asn Ala Leu Gln Asp Tyr Gly Lys 
        115                 120                 125             


Arg Ser Leu Pro Gly Val Asn Asp Phe Trp Leu Gly Ile Asn Asp Met 
    130                 135                 140                 


Val Thr Glu Gly Lys Phe Val Asp Val Asn Gly Ile Ala Ile Ser Phe 
145                 150                 155                 160 


Leu Asn Trp Asp Arg Ala Gln Pro Asn Gly Gly Lys Arg Glu Asn Cys 
                165                 170                 175     


Val Leu Phe Ser Gln Ser Ala Gln Gly Lys Trp Ser Asp Glu Ala Cys 
            180                 185                 190         


Arg Ser Ser Lys Arg Tyr Ile Cys Glu Phe Thr Ile Pro Gln 
        195                 200                 205     


<210>  3357
<211>  1014
<212>  PRT
<213>  Homo sapiens

<400>  3357

Met Val Phe Ser Val Arg Gln Cys Gly His Val Gly Arg Thr Glu Glu 
1               5                   10                  15      


Val Leu Leu Thr Phe Lys Ile Phe Leu Val Ile Ile Cys Leu His Val 
            20                  25                  30          


Val Leu Val Thr Ser Leu Glu Glu Asp Thr Asp Asn Ser Ser Leu Ser 
        35                  40                  45              


Pro Pro Pro Ala Lys Leu Ser Val Val Ser Phe Ala Pro Ser Ser Asn 
    50                  55                  60                  


Glu Val Glu Thr Thr Ser Leu Asn Asp Val Thr Leu Ser Leu Leu Pro 
65                  70                  75                  80  


Ser Asn Glu Thr Glu Lys Thr Lys Ile Thr Ile Val Lys Thr Phe Asn 
                85                  90                  95      


Ala Ser Gly Val Lys Pro Gln Arg Asn Ile Cys Asn Leu Ser Ser Ile 
            100                 105                 110         


Cys Asn Asp Ser Ala Phe Phe Arg Gly Glu Ile Met Phe Gln Tyr Asp 
        115                 120                 125             


Lys Glu Ser Thr Val Pro Gln Asn Gln His Ile Thr Asn Gly Thr Leu 
    130                 135                 140                 


Thr Gly Val Leu Ser Leu Ser Glu Leu Lys Arg Ser Glu Leu Asn Lys 
145                 150                 155                 160 


Thr Leu Gln Thr Leu Ser Glu Thr Tyr Phe Ile Met Cys Ala Thr Ala 
                165                 170                 175     


Glu Ala Gln Ser Thr Leu Asn Cys Thr Phe Thr Ile Lys Leu Asn Asn 
            180                 185                 190         


Thr Met Asn Ala Cys Ala Val Ile Ala Ala Leu Glu Arg Val Lys Ile 
        195                 200                 205             


Arg Pro Met Glu His Cys Cys Cys Ser Val Arg Ile Pro Cys Pro Ser 
    210                 215                 220                 


Ser Pro Glu Glu Leu Glu Lys Leu Gln Cys Asp Leu Gln Asp Pro Ile 
225                 230                 235                 240 


Val Cys Leu Ala Asp His Pro Arg Gly Pro Pro Phe Ser Ser Ser Gln 
                245                 250                 255     


Ser Ile Pro Val Val Pro Arg Ala Thr Val Leu Ser Gln Val Pro Lys 
            260                 265                 270         


Ala Thr Ser Phe Ala Glu Pro Pro Asp Tyr Ser Pro Val Thr His Asn 
        275                 280                 285             


Val Pro Ser Pro Ile Gly Glu Ile Gln Pro Leu Ser Pro Gln Pro Ser 
    290                 295                 300                 


Ala Pro Ile Ala Ser Ser Pro Ala Ile Asp Met Pro Pro Gln Ser Glu 
305                 310                 315                 320 


Thr Ile Ser Ser Pro Met Pro Gln Thr His Val Ser Gly Thr Pro Pro 
                325                 330                 335     


Pro Val Lys Ala Ser Phe Ser Ser Pro Thr Val Ser Ala Pro Ala Asn 
            340                 345                 350         


Val Asn Thr Thr Ser Ala Pro Pro Val Gln Thr Asp Ile Val Asn Thr 
        355                 360                 365             


Ser Ser Ile Ser Asp Leu Glu Asn Gln Val Leu Gln Met Glu Lys Ala 
    370                 375                 380                 


Leu Ser Leu Gly Ser Leu Glu Pro Asn Leu Ala Gly Glu Met Ile Asn 
385                 390                 395                 400 


Gln Val Ser Arg Leu Leu His Ser Pro Pro Asp Met Leu Ala Pro Leu 
                405                 410                 415     


Ala Gln Arg Leu Leu Lys Val Val Asp Asp Ile Gly Leu Gln Leu Asn 
            420                 425                 430         


Phe Ser Asn Thr Thr Ile Ser Leu Thr Ser Pro Ser Leu Ala Leu Ala 
        435                 440                 445             


Val Ile Arg Val Asn Ala Ser Ser Phe Asn Thr Thr Thr Phe Val Ala 
    450                 455                 460                 


Gln Asp Pro Ala Asn Leu Gln Val Ser Leu Glu Thr Gln Ala Pro Glu 
465                 470                 475                 480 


Asn Ser Ile Gly Thr Ile Thr Leu Pro Ser Ser Leu Met Asn Asn Leu 
                485                 490                 495     


Pro Ala His Asp Met Glu Leu Ala Ser Arg Val Gln Phe Asn Phe Phe 
            500                 505                 510         


Glu Thr Pro Ala Leu Phe Gln Asp Pro Ser Leu Glu Asn Leu Ser Leu 
        515                 520                 525             


Ile Ser Tyr Val Ile Ser Ser Ser Val Ala Asn Leu Thr Val Arg Asn 
    530                 535                 540                 


Leu Thr Arg Asn Val Thr Val Thr Leu Lys His Ile Asn Pro Ser Gln 
545                 550                 555                 560 


Asp Glu Leu Thr Val Arg Cys Val Phe Trp Asp Leu Gly Arg Asn Gly 
                565                 570                 575     


Gly Arg Gly Gly Trp Ser Asp Asn Gly Cys Ser Val Lys Asp Arg Arg 
            580                 585                 590         


Leu Asn Glu Thr Ile Cys Thr Cys Ser His Leu Thr Ser Phe Gly Val 
        595                 600                 605             


Leu Leu Asp Leu Ser Arg Thr Ser Val Leu Pro Ala Gln Met Met Ala 
    610                 615                 620                 


Leu Thr Phe Ile Thr Tyr Ile Gly Cys Gly Leu Ser Ser Ile Phe Leu 
625                 630                 635                 640 


Ser Val Thr Leu Val Thr Tyr Ile Ala Phe Glu Lys Ile Arg Arg Asp 
                645                 650                 655     


Tyr Pro Ser Lys Ile Leu Ile Gln Leu Cys Ala Ala Leu Leu Leu Leu 
            660                 665                 670         


Asn Leu Val Phe Leu Leu Asp Ser Trp Ile Ala Leu Tyr Lys Met Gln 
        675                 680                 685             


Gly Leu Cys Ile Ser Val Ala Val Phe Leu His Tyr Phe Leu Leu Val 
    690                 695                 700                 


Ser Phe Thr Trp Met Gly Leu Glu Ala Phe His Met Tyr Leu Ala Leu 
705                 710                 715                 720 


Val Lys Val Phe Asn Thr Tyr Ile Arg Lys Tyr Ile Leu Lys Phe Cys 
                725                 730                 735     


Ile Val Gly Trp Gly Val Pro Ala Val Val Val Thr Ile Ile Leu Thr 
            740                 745                 750         


Ile Ser Pro Asp Asn Tyr Gly Leu Gly Ser Tyr Gly Lys Phe Pro Asn 
        755                 760                 765             


Gly Ser Pro Asp Asp Phe Cys Trp Ile Asn Asn Asn Ala Val Phe Tyr 
    770                 775                 780                 


Ile Thr Val Val Gly Tyr Phe Cys Val Ile Phe Leu Leu Asn Val Ser 
785                 790                 795                 800 


Met Phe Ile Val Val Leu Val Gln Leu Cys Arg Ile Lys Lys Lys Lys 
                805                 810                 815     


Gln Leu Gly Ala Gln Arg Lys Thr Ser Ile Gln Asp Leu Arg Ser Ile 
            820                 825                 830         


Ala Gly Leu Thr Phe Leu Leu Gly Ile Thr Trp Gly Phe Ala Phe Phe 
        835                 840                 845             


Ala Trp Gly Pro Val Asn Val Thr Phe Met Tyr Leu Phe Ala Ile Phe 
    850                 855                 860                 


Asn Thr Leu Gln Gly Phe Phe Ile Phe Ile Phe Tyr Cys Val Ala Lys 
865                 870                 875                 880 


Glu Asn Val Arg Lys Gln Trp Arg Arg Tyr Leu Cys Cys Gly Lys Leu 
                885                 890                 895     


Arg Leu Ala Glu Asn Ser Asp Trp Ser Lys Thr Ala Thr Asn Gly Leu 
            900                 905                 910         


Lys Lys Gln Thr Val Asn Gln Gly Val Ser Ser Ser Ser Asn Ser Leu 
        915                 920                 925             


Gln Ser Ser Ser Asn Ser Thr Asn Ser Thr Thr Leu Leu Val Asn Asn 
    930                 935                 940                 


Asp Cys Ser Val His Ala Ser Gly Asn Gly Asn Ala Ser Thr Glu Arg 
945                 950                 955                 960 


Asn Gly Val Ser Phe Ser Val Gln Asn Gly Asp Val Cys Leu His Asp 
                965                 970                 975     


Phe Thr Gly Lys Gln His Met Phe Asn Glu Lys Glu Asp Ser Cys Asn 
            980                 985                 990         


Gly Lys Gly Arg Met Ala Leu Arg  Arg Thr Ser Lys Arg  Gly Ser Leu 
        995                 1000                 1005             


His Phe  Ile Glu Gln Met 
    1010                 


<210>  3358
<211>  1568
<212>  PRT
<213>  Homo sapiens

<400>  3358

Met Glu Val Ser Arg Arg Lys Ala Pro Pro Arg Pro Pro Arg Pro Ala 
1               5                   10                  15      


Ala Pro Leu Pro Leu Leu Ala Tyr Leu Leu Ala Leu Ala Ala Pro Gly 
            20                  25                  30          


Arg Gly Ala Asp Glu Pro Val Trp Arg Ser Glu Gln Ala Ile Gly Ala 
        35                  40                  45              


Ile Ala Ala Ser Gln Glu Asp Gly Val Phe Val Ala Ser Gly Ser Cys 
    50                  55                  60                  


Leu Asp Gln Leu Asp Tyr Ser Leu Glu His Ser Leu Ser Arg Leu Tyr 
65                  70                  75                  80  


Arg Asp Gln Ala Gly Asn Cys Thr Glu Pro Val Ser Leu Ala Pro Pro 
                85                  90                  95      


Ala Arg Pro Arg Pro Gly Ser Ser Phe Ser Lys Leu Leu Leu Pro Tyr 
            100                 105                 110         


Arg Glu Gly Ala Ala Gly Leu Gly Gly Leu Leu Leu Thr Gly Trp Thr 
        115                 120                 125             


Phe Asp Arg Gly Ala Cys Glu Val Arg Pro Leu Gly Asn Leu Ser Arg 
    130                 135                 140                 


Asn Ser Leu Arg Asn Gly Thr Glu Val Val Ser Cys His Pro Gln Gly 
145                 150                 155                 160 


Ser Thr Ala Gly Val Val Tyr Arg Ala Gly Arg Asn Asn Arg Trp Tyr 
                165                 170                 175     


Leu Ala Val Ala Ala Thr Tyr Val Leu Pro Glu Pro Glu Thr Ala Ser 
            180                 185                 190         


Arg Cys Asn Pro Ala Ala Ser Asp His Asp Thr Ala Ile Ala Leu Lys 
        195                 200                 205             


Asp Thr Glu Gly Arg Ser Leu Ala Thr Gln Glu Leu Gly Arg Leu Lys 
    210                 215                 220                 


Leu Cys Glu Gly Ala Gly Ser Leu His Phe Val Asp Ala Phe Leu Trp 
225                 230                 235                 240 


Asn Gly Ser Ile Tyr Phe Pro Tyr Tyr Pro Tyr Asn Tyr Thr Ser Gly 
                245                 250                 255     


Ala Ala Thr Gly Trp Pro Ser Met Ala Arg Ile Ala Gln Ser Thr Glu 
            260                 265                 270         


Val Leu Phe Gln Gly Gln Ala Ser Leu Asp Cys Gly His Gly His Pro 
        275                 280                 285             


Asp Gly Arg Arg Leu Leu Leu Ser Ser Ser Leu Val Glu Ala Leu Asp 
    290                 295                 300                 


Val Trp Ala Gly Val Phe Ser Ala Ala Ala Gly Glu Gly Gln Glu Arg 
305                 310                 315                 320 


Arg Ser Pro Thr Thr Thr Ala Leu Cys Leu Phe Arg Met Ser Glu Ile 
                325                 330                 335     


Gln Ala Arg Ala Lys Arg Val Ser Trp Asp Phe Lys Thr Ala Glu Ser 
            340                 345                 350         


His Cys Lys Glu Gly Asp Gln Pro Glu Arg Val Gln Pro Ile Ala Ser 
        355                 360                 365             


Ser Thr Leu Ile His Ser Asp Leu Thr Ser Val Tyr Gly Thr Val Val 
    370                 375                 380                 


Met Asn Arg Thr Val Leu Phe Leu Gly Thr Gly Asp Gly Gln Leu Leu 
385                 390                 395                 400 


Lys Val Ile Leu Gly Glu Asn Leu Thr Ser Asn Cys Pro Glu Val Ile 
                405                 410                 415     


Tyr Glu Ile Lys Glu Glu Thr Pro Val Phe Tyr Lys Leu Val Pro Asp 
            420                 425                 430         


Pro Val Lys Asn Ile Tyr Ile Tyr Leu Thr Ala Gly Lys Glu Val Arg 
        435                 440                 445             


Arg Ile Arg Val Ala Asn Cys Asn Lys His Lys Ser Cys Ser Glu Cys 
    450                 455                 460                 


Leu Thr Ala Thr Asp Pro His Cys Gly Trp Cys His Ser Leu Gln Arg 
465                 470                 475                 480 


Cys Thr Phe Gln Gly Asp Cys Val His Ser Glu Asn Leu Glu Asn Trp 
                485                 490                 495     


Leu Asp Ile Ser Ser Gly Ala Lys Lys Cys Pro Lys Ile Gln Ile Ile 
            500                 505                 510         


Arg Ser Ser Lys Glu Lys Thr Thr Val Thr Met Val Gly Ser Phe Ser 
        515                 520                 525             


Pro Arg His Ser Lys Cys Met Val Lys Asn Val Asp Ser Ser Arg Glu 
    530                 535                 540                 


Leu Cys Gln Asn Lys Ser Gln Pro Asn Arg Thr Cys Thr Cys Ser Ile 
545                 550                 555                 560 


Pro Thr Arg Ala Thr Tyr Lys Asp Val Ser Val Val Asn Val Met Phe 
                565                 570                 575     


Ser Phe Gly Ser Trp Asn Leu Ser Asp Arg Phe Asn Phe Thr Asn Cys 
            580                 585                 590         


Ser Ser Leu Lys Glu Cys Pro Ala Cys Val Glu Thr Gly Cys Ala Trp 
        595                 600                 605             


Cys Lys Ser Ala Arg Arg Cys Ile His Pro Phe Thr Ala Cys Asp Pro 
    610                 615                 620                 


Ser Asp Tyr Glu Arg Asn Gln Glu Gln Cys Pro Val Ala Val Glu Lys 
625                 630                 635                 640 


Thr Ser Gly Gly Gly Arg Pro Lys Glu Asn Lys Gly Asn Arg Thr Asn 
                645                 650                 655     


Gln Ala Leu Gln Val Phe Tyr Ile Lys Ser Ile Glu Pro Gln Lys Val 
            660                 665                 670         


Ser Thr Leu Gly Lys Ser Asn Val Ile Val Thr Gly Ala Asn Phe Thr 
        675                 680                 685             


Arg Ala Ser Asn Ile Thr Met Ile Leu Lys Gly Thr Ser Thr Cys Asp 
    690                 695                 700                 


Lys Asp Val Ile Gln Val Ser His Val Leu Asn Asp Thr His Met Lys 
705                 710                 715                 720 


Phe Ser Leu Pro Ser Ser Arg Lys Glu Met Lys Asp Val Cys Ile Gln 
                725                 730                 735     


Phe Asp Gly Gly Asn Cys Ser Ser Val Gly Ser Leu Ser Tyr Ile Ala 
            740                 745                 750         


Leu Pro His Cys Ser Leu Ile Phe Pro Ala Thr Thr Trp Ile Ser Gly 
        755                 760                 765             


Gly Gln Asn Ile Thr Met Met Gly Arg Asn Phe Asp Val Ile Asp Asn 
    770                 775                 780                 


Leu Ile Ile Ser His Glu Leu Lys Gly Asn Ile Asn Val Ser Glu Tyr 
785                 790                 795                 800 


Cys Val Ala Thr Tyr Cys Gly Phe Leu Ala Pro Ser Leu Lys Ser Ser 
                805                 810                 815     


Lys Val Arg Thr Asn Val Thr Val Lys Leu Arg Val Gln Asp Thr Tyr 
            820                 825                 830         


Leu Asp Cys Gly Thr Leu Gln Tyr Arg Glu Asp Pro Arg Phe Thr Gly 
        835                 840                 845             


Tyr Arg Val Glu Ser Glu Val Asp Thr Glu Leu Glu Val Lys Ile Gln 
    850                 855                 860                 


Lys Glu Asn Asp Asn Phe Asn Ile Ser Lys Lys Asp Ile Glu Ile Thr 
865                 870                 875                 880 


Leu Phe His Gly Glu Asn Gly Gln Leu Asn Cys Ser Phe Glu Asn Ile 
                885                 890                 895     


Thr Arg Asn Gln Asp Leu Thr Thr Ile Leu Cys Lys Ile Lys Gly Ile 
            900                 905                 910         


Lys Thr Ala Ser Thr Ile Ala Asn Ser Ser Lys Lys Val Arg Val Lys 
        915                 920                 925             


Leu Gly Asn Leu Glu Leu Tyr Val Glu Gln Glu Ser Val Pro Ser Thr 
    930                 935                 940                 


Trp Tyr Phe Leu Ile Val Leu Pro Val Leu Leu Val Ile Val Ile Phe 
945                 950                 955                 960 


Ala Ala Val Gly Val Thr Arg His Lys Ser Lys Glu Leu Ser Arg Lys 
                965                 970                 975     


Gln Ser Gln Gln Leu Glu Leu Leu Glu Ser Glu Leu Arg Lys Glu Ile 
            980                 985                 990         


Arg Asp Gly Phe Ala Glu Leu Gln  Met Asp Lys Leu Asp  Val Val Asp 
        995                 1000                 1005             


Ser Phe  Gly Thr Val Pro Phe  Leu Asp Tyr Lys His  Phe Ala Leu 
    1010                 1015                 1020             


Arg Thr  Phe Phe Pro Glu Ser  Gly Gly Phe Thr His  Ile Phe Thr 
    1025                 1030                 1035             


Glu Asp  Met His Asn Arg Asp  Ala Asn Asp Lys Asn  Glu Ser Leu 
    1040                 1045                 1050             


Thr Ala  Leu Asp Ala Leu Ile  Cys Asn Lys Ser Phe  Leu Val Thr 
    1055                 1060                 1065             


Val Ile  His Thr Leu Glu Lys  Gln Lys Asn Phe Ser  Val Lys Asp 
    1070                 1075                 1080             


Arg Cys  Leu Phe Ala Ser Phe  Leu Thr Ile Ala Leu  Gln Thr Lys 
    1085                 1090                 1095             


Leu Val  Tyr Leu Thr Ser Ile  Leu Glu Val Leu Thr  Arg Asp Leu 
    1100                 1105                 1110             


Met Glu  Gln Cys Ser Asn Met  Gln Pro Lys Leu Met  Leu Arg Arg 
    1115                 1120                 1125             


Thr Glu  Ser Val Val Glu Lys  Leu Leu Thr Asn Trp  Met Ser Val 
    1130                 1135                 1140             


Cys Leu  Ser Gly Phe Leu Arg  Glu Thr Val Gly Glu  Pro Phe Tyr 
    1145                 1150                 1155             


Leu Leu  Val Thr Thr Leu Asn  Gln Lys Ile Asn Lys  Gly Pro Val 
    1160                 1165                 1170             


Asp Val  Ile Thr Cys Lys Ala  Leu Tyr Thr Leu Asn  Glu Asp Trp 
    1175                 1180                 1185             


Leu Leu  Trp Gln Val Pro Glu  Phe Ser Thr Val Ala  Leu Asn Val 
    1190                 1195                 1200             


Val Phe  Glu Lys Ile Pro Glu  Asn Glu Ser Ala Asp  Val Cys Arg 
    1205                 1210                 1215             


Asn Ile  Ser Val Asn Val Leu  Asp Cys Asp Thr Ile  Gly Gln Ala 
    1220                 1225                 1230             


Lys Glu  Lys Ile Phe Gln Ala  Phe Leu Ser Lys Asn  Gly Ser Pro 
    1235                 1240                 1245             


Tyr Gly  Leu Gln Leu Asn Glu  Ile Gly Leu Glu Leu  Gln Met Gly 
    1250                 1255                 1260             


Thr Arg  Gln Lys Glu Leu Leu  Asp Ile Asp Ser Ser  Ser Val Ile 
    1265                 1270                 1275             


Leu Glu  Asp Gly Ile Thr Lys  Leu Asn Thr Ile Gly  His Tyr Glu 
    1280                 1285                 1290             


Ile Ser  Asn Gly Ser Thr Ile  Lys Val Phe Lys Lys  Ile Ala Asn 
    1295                 1300                 1305             


Phe Thr  Ser Asp Val Glu Tyr  Ser Asp Asp His Cys  His Leu Ile 
    1310                 1315                 1320             


Leu Pro  Asp Ser Glu Ala Phe  Gln Asp Val Gln Gly  Lys Arg His 
    1325                 1330                 1335             


Arg Gly  Lys His Lys Phe Lys  Val Lys Glu Met Tyr  Leu Thr Lys 
    1340                 1345                 1350             


Leu Leu  Ser Thr Lys Val Ala  Ile His Ser Val Leu  Glu Lys Leu 
    1355                 1360                 1365             


Phe Arg  Ser Ile Trp Ser Leu  Pro Asn Ser Arg Ala  Pro Phe Ala 
    1370                 1375                 1380             


Ile Lys  Tyr Phe Phe Asp Phe  Leu Asp Ala Gln Ala  Glu Asn Lys 
    1385                 1390                 1395             


Lys Ile  Thr Asp Pro Asp Val  Val His Ile Trp Lys  Thr Asn Ser 
    1400                 1405                 1410             


Leu Pro  Leu Arg Phe Trp Val  Asn Ile Leu Lys Asn  Pro Gln Phe 
    1415                 1420                 1425             


Val Phe  Asp Ile Lys Lys Thr  Pro His Ile Asp Gly  Cys Leu Ser 
    1430                 1435                 1440             


Val Ile  Ala Gln Ala Phe Met  Asp Ala Phe Ser Leu  Thr Glu Gln 
    1445                 1450                 1455             


Gln Leu  Gly Lys Glu Ala Pro  Thr Asn Lys Leu Leu  Tyr Ala Lys 
    1460                 1465                 1470             


Asp Ile  Pro Thr Tyr Lys Glu  Glu Val Lys Ser Tyr  Tyr Lys Ala 
    1475                 1480                 1485             


Ile Arg  Asp Leu Pro Pro Leu  Ser Ser Ser Glu Met  Glu Glu Phe 
    1490                 1495                 1500             


Leu Thr  Gln Glu Ser Lys Lys  His Glu Asn Glu Phe  Asn Glu Glu 
    1505                 1510                 1515             


Val Ala  Leu Thr Glu Ile Tyr  Lys Tyr Ile Val Lys  Tyr Phe Asp 
    1520                 1525                 1530             


Glu Ile  Leu Asn Lys Leu Glu  Arg Glu Arg Gly Leu  Glu Glu Ala 
    1535                 1540                 1545             


Gln Lys  Gln Leu Leu His Val  Lys Val Leu Phe Asp  Glu Lys Lys 
    1550                 1555                 1560             


Lys Cys  Lys Trp Met 
    1565             


<210>  3359
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  3359

Met Ser Ala Leu Ser Leu Leu Ile Leu Gly Leu Leu Thr Ala Val Pro 
1               5                   10                  15      


Pro Ala Ser Cys Gln Gln Gly Leu Gly Asn Leu Gln Pro Trp Met Gln 
            20                  25                  30          


Gly Leu Ile Ala Val Ala Val Phe Leu Val Leu Val Ala Ile Ala Phe 
        35                  40                  45              


Ala Val Asn His Phe Trp Cys Gln Glu Glu Pro Glu Pro Ala His Met 
    50                  55                  60                  


Ile Leu Thr Val Gly Asn Lys Ala Asp Gly Val Leu Val Gly Thr Asp 
65                  70                  75                  80  


Gly Arg Tyr Ser Ser Met Ala Ala Ser Phe Arg Ser Ser Glu His Glu 
                85                  90                  95      


Asn Ala Tyr Glu Asn Val Pro Glu Glu Glu Gly Lys Val Arg Ser Thr 
            100                 105                 110         


Pro Met 
        


<210>  3360
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  3360

Met Ala Val Phe Val Val Leu Leu Ala Leu Val Ala Gly Val Leu Gly 
1               5                   10                  15      


Asn Glu Phe Ser Ile Leu Lys Ser Pro Gly Ser Val Val Phe Arg Asn 
            20                  25                  30          


Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala Leu 
        35                  40                  45              


Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala 
    50                  55                  60                  


Val Gly Asn Leu Phe His Arg Pro Arg Ala Thr Val Met Val Met Val 
65                  70                  75                  80  


Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr 
                85                  90                  95      


Pro Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser Val Ala Asn Ser 
            100                 105                 110         


Ile His Ser Leu Phe Ser Glu Glu Thr Pro Val Val Leu Gln Leu Ala 
        115                 120                 125             


Pro Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val Phe 
    130                 135                 140                 


Glu Asp Leu Ser Val Thr Leu Arg Gln Leu Arg Asn Arg Leu Phe Gln 
145                 150                 155                 160 


Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser Leu Ser Arg Asn 
                165                 170                 175     


Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln Val Leu His Asp 
            180                 185                 190         


Ile Ser Ser Leu Leu Ser Arg His Lys His Leu Ala Lys Asp His Ser 
        195                 200                 205             


Pro Asp Leu Tyr Ser Leu Glu Leu Ala Gly Leu Asp Glu Ile Gly Lys 
    210                 215                 220                 


Arg Tyr Gly Glu Asp Ser Glu Gln Phe Arg Asp Ala Ser Lys Ile Leu 
225                 230                 235                 240 


Val Asp Ala Leu Gln Lys Phe Ala Asp Asp Met Tyr Ser Leu Tyr Gly 
                245                 250                 255     


Gly Asn Ala Val Val Glu Leu Val Thr Val Lys Ser Phe Asp Thr Ser 
            260                 265                 270         


Leu Ile Arg Lys Thr Arg Thr Ile Leu Glu Ala Lys Gln Ala Lys Asn 
        275                 280                 285             


Pro Ala Ser Pro Tyr Asn Leu Ala Tyr Lys Tyr Asn Phe Glu Tyr Ser 
    290                 295                 300                 


Val Val Phe Asn Met Val Leu Trp Ile Met Ile Ala Leu Ala Leu Ala 
305                 310                 315                 320 


Val Ile Ile Thr Ser Tyr Asn Ile Trp Asn Met Asp Pro Gly Tyr Asp 
                325                 330                 335     


Ser Ile Ile Tyr Arg Met Thr Asn Gln Lys Ile Arg Met Asp 
            340                 345                 350 


<210>  3361
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  3361

Met Val Ser Val Asn Ser Ser His Cys Phe Tyr Asn Asp Ser Phe Lys 
1               5                   10                  15      


Tyr Thr Leu Tyr Gly Cys Met Phe Ser Met Val Phe Val Leu Gly Leu 
            20                  25                  30          


Ile Ser Asn Cys Val Ala Ile Tyr Ile Phe Ile Cys Val Leu Lys Val 
        35                  40                  45              


Arg Asn Glu Thr Thr Thr Tyr Met Ile Asn Leu Ala Met Ser Asp Leu 
    50                  55                  60                  


Leu Phe Val Phe Thr Leu Pro Phe Arg Ile Phe Tyr Phe Thr Thr Arg 
65                  70                  75                  80  


Asn Trp Pro Phe Gly Asp Leu Leu Cys Lys Ile Ser Val Met Leu Phe 
                85                  90                  95      


Tyr Thr Asn Met Tyr Gly Ser Ile Leu Phe Leu Thr Cys Ile Ser Val 
            100                 105                 110         


Asp Arg Phe Leu Ala Ile Val Tyr Pro Phe Lys Ser Lys Thr Leu Arg 
        115                 120                 125             


Thr Lys Arg Asn Ala Lys Ile Val Cys Thr Gly Val Trp Leu Thr Val 
    130                 135                 140                 


Ile Gly Gly Ser Ala Pro Ala Val Phe Val Gln Ser Thr His Ser Gln 
145                 150                 155                 160 


Gly Asn Asn Ala Ser Glu Ala Cys Phe Glu Asn Phe Pro Glu Ala Thr 
                165                 170                 175     


Trp Lys Thr Tyr Leu Ser Arg Ile Val Ile Phe Ile Glu Ile Val Gly 
            180                 185                 190         


Phe Phe Ile Pro Leu Ile Leu Asn Val Thr Cys Ser Ser Met Val Leu 
        195                 200                 205             


Lys Thr Leu Thr Lys Pro Val Thr Leu Ser Arg Ser Lys Ile Asn Lys 
    210                 215                 220                 


Thr Lys Val Leu Lys Met Ile Phe Val His Leu Ile Ile Phe Cys Phe 
225                 230                 235                 240 


Cys Phe Val Pro Tyr Asn Ile Asn Leu Ile Leu Tyr Ser Leu Val Arg 
                245                 250                 255     


Thr Gln Thr Phe Val Asn Cys Ser Val Val Ala Ala Val Arg Thr Met 
            260                 265                 270         


Tyr Pro Ile Thr Leu Cys Ile Ala Val Ser Asn Cys Cys Phe Asp Pro 
        275                 280                 285             


Ile Val Tyr Tyr Phe Thr Ser Asp Thr Ile Gln Asn Ser Ile Lys Met 
    290                 295                 300                 


Lys Asn Trp Ser Val Arg Arg Ser Asp Phe Arg Phe Ser Glu Val His 
305                 310                 315                 320 


Gly Ala Glu Asn Phe Ile Gln His Asn Leu Gln Thr Leu Lys Ser Lys 
                325                 330                 335     


Ile Phe Asp Asn Glu Ser Ala Ala 
            340                 


<210>  3362
<211>  487
<212>  PRT
<213>  Homo sapiens

<400>  3362

Met Ala Ser Ser Ala Glu Gly Asp Glu Gly Thr Val Val Ala Leu Ala 
1               5                   10                  15      


Gly Val Leu Gln Ser Gly Phe Gln Glu Leu Ser Leu Asn Lys Leu Ala 
            20                  25                  30          


Thr Ser Leu Gly Ala Ser Glu Gln Ala Leu Arg Leu Ile Ile Ser Ile 
        35                  40                  45              


Phe Leu Gly Tyr Pro Phe Ala Leu Phe Tyr Arg His Tyr Leu Phe Tyr 
    50                  55                  60                  


Lys Glu Thr Tyr Leu Ile His Leu Phe His Thr Phe Thr Gly Leu Ser 
65                  70                  75                  80  


Ile Ala Tyr Phe Asn Phe Gly Asn Gln Leu Tyr His Ser Leu Leu Cys 
                85                  90                  95      


Ile Val Leu Gln Phe Leu Ile Leu Arg Leu Met Gly Arg Thr Ile Thr 
            100                 105                 110         


Ala Val Leu Thr Thr Phe Cys Phe Gln Met Ala Tyr Leu Leu Ala Gly 
        115                 120                 125             


Tyr Tyr Tyr Thr Ala Thr Gly Asn Tyr Asp Ile Lys Trp Thr Met Pro 
    130                 135                 140                 


His Cys Val Leu Thr Leu Lys Leu Ile Gly Leu Ala Val Asp Tyr Phe 
145                 150                 155                 160 


Asp Gly Gly Lys Asp Gln Asn Ser Leu Ser Ser Glu Gln Gln Lys Tyr 
                165                 170                 175     


Ala Ile Arg Gly Val Pro Ser Leu Leu Glu Val Ala Gly Phe Ser Tyr 
            180                 185                 190         


Phe Tyr Gly Ala Phe Leu Val Gly Pro Gln Phe Ser Met Asn His Tyr 
        195                 200                 205             


Met Lys Leu Val Gln Gly Glu Leu Ile Asp Ile Pro Gly Lys Ile Pro 
    210                 215                 220                 


Asn Ser Ile Ile Pro Ala Leu Lys Arg Leu Ser Leu Gly Leu Phe Tyr 
225                 230                 235                 240 


Leu Val Gly Tyr Thr Leu Leu Ser Pro His Ile Thr Glu Asp Tyr Leu 
                245                 250                 255     


Leu Thr Glu Asp Tyr Asp Asn His Pro Phe Trp Phe Arg Cys Met Tyr 
            260                 265                 270         


Met Leu Ile Trp Gly Lys Phe Val Leu Tyr Lys Tyr Val Thr Cys Trp 
        275                 280                 285             


Leu Val Thr Glu Gly Val Cys Ile Leu Thr Gly Leu Gly Phe Asn Gly 
    290                 295                 300                 


Phe Glu Glu Lys Gly Lys Ala Lys Trp Asp Ala Cys Ala Asn Met Lys 
305                 310                 315                 320 


Val Trp Leu Phe Glu Thr Asn Pro Arg Phe Thr Gly Thr Ile Ala Ser 
                325                 330                 335     


Phe Asn Ile Asn Thr Asn Ala Trp Val Ala Arg Tyr Ile Phe Lys Arg 
            340                 345                 350         


Leu Lys Phe Leu Gly Asn Lys Glu Leu Ser Gln Gly Leu Ser Leu Leu 
        355                 360                 365             


Phe Leu Ala Leu Trp His Gly Leu His Ser Gly Tyr Leu Val Cys Phe 
    370                 375                 380                 


Gln Met Glu Phe Leu Ile Val Ile Val Glu Arg Gln Ala Ala Arg Leu 
385                 390                 395                 400 


Ile Gln Glu Ser Pro Thr Leu Ser Lys Leu Ala Ala Ile Thr Val Leu 
                405                 410                 415     


Gln Pro Phe Tyr Tyr Leu Val Gln Gln Thr Ile His Trp Leu Phe Met 
            420                 425                 430         


Gly Tyr Ser Met Thr Ala Phe Cys Leu Phe Thr Trp Asp Lys Trp Leu 
        435                 440                 445             


Lys Val Tyr Lys Ser Ile Tyr Phe Leu Gly His Ile Phe Phe Leu Ser 
    450                 455                 460                 


Leu Leu Phe Ile Leu Pro Tyr Ile His Lys Ala Met Val Pro Arg Lys 
465                 470                 475                 480 


Glu Lys Leu Lys Lys Met Glu 
                485         


<210>  3363
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  3363

Met Leu Leu Pro Lys Lys Met Lys Leu Leu Leu Phe Leu Val Ser Gln 
1               5                   10                  15      


Met Ala Ile Leu Ala Leu Phe Phe His Met Tyr Ser His Asn Ile Ser 
            20                  25                  30          


Ser Leu Ser Met Lys Ala Gln Pro Glu Arg Met His Val Leu Val Leu 
        35                  40                  45              


Ser Ser Trp Arg Ser Gly Ser Ser Phe Val Gly Gln Leu Phe Gly Gln 
    50                  55                  60                  


His Pro Asp Val Phe Tyr Leu Met Glu Pro Ala Trp His Val Trp Met 
65                  70                  75                  80  


Thr Phe Lys Gln Ser Thr Ala Trp Met Leu His Met Ala Val Arg Asp 
                85                  90                  95      


Leu Ile Arg Ala Val Phe Leu Cys Asp Met Ser Val Phe Asp Ala Tyr 
            100                 105                 110         


Met Glu Pro Gly Pro Arg Arg Gln Ser Ser Leu Phe Gln Trp Glu Asn 
        115                 120                 125             


Ser Arg Ala Leu Cys Ser Ala Pro Ala Cys Asp Ile Ile Pro Gln Asp 
    130                 135                 140                 


Glu Ile Ile Pro Arg Ala His Cys Arg Leu Leu Cys Ser Gln Gln Pro 
145                 150                 155                 160 


Phe Glu Val Val Glu Lys Ala Cys Arg Ser Tyr Ser His Val Val Leu 
                165                 170                 175     


Lys Glu Val Arg Phe Phe Asn Leu Gln Ser Leu Tyr Pro Leu Leu Lys 
            180                 185                 190         


Asp Pro Ser Leu Asn Leu His Ile Val His Leu Val Arg Asp Pro Arg 
        195                 200                 205             


Ala Val Phe Arg Ser Arg Glu Arg Thr Lys Gly Asp Leu Met Ile Asp 
    210                 215                 220                 


Ser Arg Ile Val Met Gly Gln His Glu Gln Lys Leu Lys Lys Glu Asp 
225                 230                 235                 240 


Gln Pro Tyr Tyr Val Met Gln Val Ile Cys Gln Ser Gln Leu Glu Ile 
                245                 250                 255     


Tyr Lys Thr Ile Gln Ser Leu Pro Lys Ala Leu Gln Glu Arg Tyr Leu 
            260                 265                 270         


Leu Val Arg Tyr Glu Asp Leu Ala Arg Ala Pro Val Ala Gln Thr Ser 
        275                 280                 285             


Arg Met Tyr Glu Phe Val Gly Leu Glu Phe Leu Pro His Leu Gln Thr 
    290                 295                 300                 


Trp Val His Asn Ile Thr Arg Gly Lys Gly Met Gly Asp His Ala Phe 
305                 310                 315                 320 


His Thr Asn Ala Arg Asp Ala Leu Asn Val Ser Gln Ala Trp Arg Trp 
                325                 330                 335     


Ser Leu Pro Tyr Glu Lys Val Ser Arg Leu Gln Lys Ala Cys Gly Asp 
            340                 345                 350         


Ala Met Asn Leu Leu Gly Tyr Arg His Val Arg Ser Glu Gln Glu Gln 
        355                 360                 365             


Arg Asn Leu Leu Leu Asp Leu Leu Ser Thr Trp Thr Val Pro Glu Gln 
    370                 375                 380                 


Ile His 
385     


<210>  3364
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  3364

Met Leu Phe Trp Val Leu Gly Leu Leu Ile Leu Cys Gly Phe Leu Trp 
1               5                   10                  15      


Thr Arg Lys Gly Lys Leu Lys Ile Glu Asp Ile Thr Asp Lys Tyr Ile 
            20                  25                  30          


Phe Ile Thr Gly Cys Asp Ser Gly Phe Gly Asn Leu Ala Ala Arg Thr 
        35                  40                  45              


Phe Asp Lys Lys Gly Phe His Val Ile Ala Ala Cys Leu Thr Glu Ser 
    50                  55                  60                  


Gly Ser Thr Ala Leu Lys Ala Glu Thr Ser Glu Arg Leu Arg Thr Val 
65                  70                  75                  80  


Leu Leu Asp Val Thr Asp Pro Glu Asn Val Lys Arg Thr Ala Gln Trp 
                85                  90                  95      


Val Lys Asn Gln Val Gly Glu Lys Gly Leu Trp Gly Leu Ile Asn Asn 
            100                 105                 110         


Ala Gly Val Pro Gly Val Leu Ala Pro Thr Asp Trp Leu Thr Leu Glu 
        115                 120                 125             


Asp Tyr Arg Glu Pro Ile Glu Val Asn Leu Phe Gly Leu Ile Ser Val 
    130                 135                 140                 


Thr Leu Asn Met Leu Pro Leu Val Lys Lys Ala Gln Gly Arg Val Ile 
145                 150                 155                 160 


Asn Val Ser Ser Val Gly Gly Arg Leu Ala Ile Val Gly Gly Gly Tyr 
                165                 170                 175     


Thr Pro Ser Lys Tyr Ala Val Glu Gly Phe Asn Asp Ser Leu Arg Arg 
            180                 185                 190         


Asp Met Lys Ala Phe Gly Val His Val Ser Cys Ile Glu Pro Gly Leu 
        195                 200                 205             


Phe Lys Thr Asn Leu Ala Asp Pro Val Lys Val Ile Glu Lys Lys Leu 
    210                 215                 220                 


Ala Ile Trp Glu Gln Leu Ser Pro Asp Ile Lys Gln Gln Tyr Gly Glu 
225                 230                 235                 240 


Gly Tyr Ile Glu Lys Ser Leu Asp Lys Leu Lys Gly Asn Lys Ser Tyr 
                245                 250                 255     


Val Asn Met Asp Leu Ser Pro Val Val Glu Cys Met Asp His Ala Leu 
            260                 265                 270         


Thr Ser Leu Phe Pro Lys Thr His Tyr Ala Ala Gly Lys Asp Ala Lys 
        275                 280                 285             


Ile Phe Trp Ile Pro Leu Ser His Met Pro Ala Ala Leu Gln Asp Phe 
    290                 295                 300                 


Leu Leu Leu Lys Gln Lys Ala Glu Leu Ala Asn Pro Lys Ala Val 
305                 310                 315                 


<210>  3365
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  3365

Met Ala Phe Thr Phe Ala Ala Phe Cys Tyr Met Leu Ala Leu Leu Leu 
1               5                   10                  15      


Thr Ala Ala Leu Ile Phe Phe Ala Ile Trp His Ile Ile Ala Phe Asp 
            20                  25                  30          


Glu Leu Lys Thr Asp Tyr Lys Asn Pro Ile Asp Gln Cys Asn Thr Leu 
        35                  40                  45              


Asn Pro Leu Val Leu Pro Glu Tyr Leu Ile His Ala Phe Phe Cys Val 
    50                  55                  60                  


Met Phe Leu Cys Ala Ala Glu Trp Leu Thr Leu Gly Leu Asn Met Pro 
65                  70                  75                  80  


Leu Leu Ala Tyr His Ile Trp Arg Tyr Met Ser Arg Pro Val Met Ser 
                85                  90                  95      


Gly Pro Gly Leu Tyr Asp Pro Thr Thr Ile Met Asn Ala Asp Ile Leu 
            100                 105                 110         


Ala Tyr Cys Gln Lys Glu Gly Trp Cys Lys Leu Ala Phe Tyr Leu Leu 
        115                 120                 125             


Ala Phe Phe Tyr Tyr Leu Tyr Gly Met Ile Tyr Val Leu Val Ser Ser 
    130                 135                 140                 


<210>  3366
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  3366

Met Cys His Val Ile Val Thr Cys Arg Ser Met Leu Trp Thr Leu Leu 
1               5                   10                  15      


Ser Ile Val Val Ala Phe Ala Glu Leu Ile Ala Phe Met Ser Ala Asp 
            20                  25                  30          


Trp Leu Ile Gly Lys Ala Arg Ser Arg Gly Gly Val Glu Pro Ala Gly 
        35                  40                  45              


Pro Gly Gly Gly Ser Pro Glu Pro Tyr His Pro Thr Leu Gly Ile Tyr 
    50                  55                  60                  


Ala Arg Cys Ile Arg Asn Pro Gly Val Gln His Phe Gln Arg Asp Thr 
65                  70                  75                  80  


Leu Cys Gly Pro Tyr Ala Glu Ser Phe Gly Glu Ile Ala Ser Gly Phe 
                85                  90                  95      


Trp Gln Ala Thr Ala Ile Phe Leu Ala Val Gly Ile Phe Ile Leu Cys 
            100                 105                 110         


Met Val Ala Leu Val Ser Val Phe Thr Met Cys Val Gln Ser Ile Met 
        115                 120                 125             


Lys Lys Ser Ile Phe Asn Val Cys Gly Leu Leu Gln Gly Ile Ala Gly 
    130                 135                 140                 


Leu Phe Leu Ile Leu Gly Leu Ile Leu Tyr Pro Ala Gly Trp Gly Cys 
145                 150                 155                 160 


Gln Lys Ala Ile Asp Tyr Cys Gly His Tyr Ala Ser Ala Tyr Lys Pro 
                165                 170                 175     


Gly Asp Cys Ser Leu Gly Trp Ala Phe Tyr Thr Ala Ile Gly Gly Thr 
            180                 185                 190         


Val Leu Thr Phe Ile Cys Ala Val Phe Ser Ala Gln Ala Glu Ile Ala 
        195                 200                 205             


Thr Ser Ser Asp Lys Val Gln Glu Glu Ile Glu Glu Gly Lys Asn Leu 
    210                 215                 220                 


Ile Cys Leu Leu 
225             


<210>  3367
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  3367

Met Ala Ser Ser Leu Thr Cys Thr Gly Val Ile Trp Ala Leu Leu Ser 
1               5                   10                  15      


Phe Leu Cys Ala Ala Thr Ser Cys Val Gly Phe Phe Met Pro Tyr Trp 
            20                  25                  30          


Leu Trp Gly Ser Gln Leu Gly Lys Pro Val Ser Phe Gly Thr Phe Arg 
        35                  40                  45              


Arg Cys Ser Tyr Pro Val His Asp Glu Ser Arg Gln Met Met Val Met 
    50                  55                  60                  


Val Glu Glu Cys Gly Arg Tyr Ala Ser Phe Gln Gly Ile Pro Ser Ala 
65                  70                  75                  80  


Glu Trp Arg Ile Cys Thr Ile Val Thr Gly Leu Gly Cys Gly Leu Leu 
                85                  90                  95      


Leu Leu Val Ala Leu Thr Ala Leu Met Gly Cys Cys Val Ser Asp Leu 
            100                 105                 110         


Ile Ser Arg Thr Val Gly Arg Val Ala Gly Gly Ile Gln Phe Leu Gly 
        115                 120                 125             


Gly Leu Leu Ile Gly Ala Gly Cys Ala Leu Tyr Pro Leu Gly Trp Asp 
    130                 135                 140                 


Ser Glu Glu Val Arg Gln Thr Cys Gly Tyr Thr Ser Gly Gln Phe Asp 
145                 150                 155                 160 


Leu Gly Lys Cys Glu Ile Gly Trp Ala Tyr Tyr Cys Thr Gly Ala Gly 
                165                 170                 175     


Ala Thr Ala Ala Met Leu Leu Cys Thr Trp Leu Ala Cys Phe Ser Gly 
            180                 185                 190         


Lys Lys Gln Lys His Tyr Pro Tyr 
        195                 200 


<210>  3368
<211>  438
<212>  PRT
<213>  Homo sapiens

<400>  3368

Met Ala Ala Gly Leu Arg Lys Arg Gly Arg Ser Gly Ser Ala Ala Gln 
1               5                   10                  15      


Ala Glu Gly Leu Cys Lys Gln Trp Leu Gln Arg Ala Trp Gln Glu Arg 
            20                  25                  30          


Arg Leu Leu Leu Arg Glu Pro Arg Tyr Thr Leu Leu Val Ala Ala Cys 
        35                  40                  45              


Leu Cys Leu Ala Glu Val Gly Ile Thr Phe Trp Val Ile His Arg Val 
    50                  55                  60                  


Ala Tyr Thr Glu Ile Asp Trp Lys Ala Tyr Met Ala Glu Val Glu Gly 
65                  70                  75                  80  


Val Ile Asn Gly Thr Tyr Asp Tyr Thr Gln Leu Gln Gly Asp Thr Gly 
                85                  90                  95      


Pro Leu Val Tyr Pro Ala Gly Phe Val Tyr Ile Phe Met Gly Leu Tyr 
            100                 105                 110         


Tyr Ala Thr Ser Arg Gly Thr Asp Ile Arg Met Ala Gln Asn Ile Phe 
        115                 120                 125             


Ala Val Leu Tyr Leu Ala Thr Leu Leu Leu Val Phe Leu Ile Tyr His 
    130                 135                 140                 


Gln Thr Cys Lys Val Pro Pro Phe Val Phe Phe Phe Met Cys Cys Ala 
145                 150                 155                 160 


Ser Tyr Arg Val His Ser Ile Phe Val Leu Arg Leu Phe Asn Asp Pro 
                165                 170                 175     


Val Ala Met Val Leu Leu Phe Leu Ser Ile Asn Leu Leu Leu Ala Gln 
            180                 185                 190         


Arg Trp Gly Trp Gly Cys Cys Phe Phe Ser Leu Ala Val Ser Val Lys 
        195                 200                 205             


Met Asn Val Leu Leu Phe Ala Pro Gly Leu Leu Phe Leu Leu Leu Thr 
    210                 215                 220                 


Gln Phe Gly Phe Arg Gly Ala Leu Pro Lys Leu Gly Ile Cys Ala Gly 
225                 230                 235                 240 


Leu Gln Val Val Leu Gly Leu Pro Phe Leu Leu Glu Asn Pro Ser Gly 
                245                 250                 255     


Tyr Leu Ser Arg Ser Phe Asp Leu Gly Arg Gln Phe Leu Phe His Trp 
            260                 265                 270         


Thr Val Asn Trp Arg Phe Leu Pro Glu Ala Leu Phe Leu His Arg Ala 
        275                 280                 285             


Phe His Leu Ala Leu Leu Thr Ala His Leu Thr Leu Leu Leu Leu Phe 
    290                 295                 300                 


Ala Leu Cys Arg Trp His Arg Thr Gly Glu Ser Ile Leu Ser Leu Leu 
305                 310                 315                 320 


Arg Asp Pro Ser Lys Arg Lys Val Pro Pro Gln Pro Leu Thr Pro Asn 
                325                 330                 335     


Gln Ile Val Ser Thr Leu Phe Thr Ser Asn Phe Ile Gly Ile Cys Phe 
            340                 345                 350         


Ser Arg Ser Leu His Tyr Gln Phe Tyr Val Trp Tyr Phe His Thr Leu 
        355                 360                 365             


Pro Tyr Leu Leu Trp Ala Met Pro Ala Arg Trp Leu Thr His Leu Leu 
    370                 375                 380                 


Arg Leu Leu Val Leu Gly Leu Ile Glu Leu Ser Trp Asn Thr Tyr Pro 
385                 390                 395                 400 


Ser Thr Ser Cys Ser Ser Ala Ala Leu His Ile Cys His Ala Val Ile 
                405                 410                 415     


Leu Leu Gln Leu Trp Leu Gly Pro Gln Pro Phe Pro Lys Ser Thr Gln 
            420                 425                 430         


His Ser Lys Lys Ala His 
        435             


<210>  3369
<211>  280
<212>  PRT
<213>  Homo sapiens

<400>  3369

Met Leu Ser Ala Val Ala Arg Gly Tyr Gln Gly Trp Phe His Pro Cys 
1               5                   10                  15      


Ala Arg Leu Ser Val Arg Met Ser Ser Thr Gly Ile Asp Arg Lys Gly 
            20                  25                  30          


Val Leu Ala Asn Arg Val Ala Val Val Thr Gly Ser Thr Ser Gly Ile 
        35                  40                  45              


Gly Phe Ala Ile Ala Arg Arg Leu Ala Arg Asp Gly Ala His Val Val 
    50                  55                  60                  


Ile Ser Ser Arg Lys Gln Gln Asn Val Asp Arg Ala Met Ala Lys Leu 
65                  70                  75                  80  


Gln Gly Glu Gly Leu Ser Val Ala Gly Ile Val Cys His Val Gly Lys 
                85                  90                  95      


Ala Glu Asp Arg Glu Gln Leu Val Ala Lys Ala Leu Glu His Cys Gly 
            100                 105                 110         


Gly Val Asp Phe Leu Val Cys Ser Ala Gly Val Asn Pro Leu Val Gly 
        115                 120                 125             


Ser Thr Leu Gly Thr Ser Glu Gln Ile Trp Asp Lys Ile Leu Ser Val 
    130                 135                 140                 


Asn Val Lys Ser Pro Ala Leu Leu Leu Ser Gln Leu Leu Pro Tyr Met 
145                 150                 155                 160 


Glu Asn Arg Arg Gly Ala Val Ile Leu Val Ser Ser Ile Ala Ala Tyr 
                165                 170                 175     


Asn Pro Val Val Ala Leu Gly Val Tyr Asn Val Ser Lys Thr Ala Leu 
            180                 185                 190         


Leu Gly Leu Thr Arg Thr Leu Ala Leu Glu Leu Ala Pro Lys Asp Ile 
        195                 200                 205             


Arg Val Asn Cys Val Val Pro Gly Ile Ile Lys Thr Asp Phe Ser Lys 
    210                 215                 220                 


Val Phe His Gly Asn Glu Ser Leu Trp Lys Asn Phe Lys Glu His His 
225                 230                 235                 240 


Gln Leu Gln Arg Ile Gly Glu Ser Glu Asp Cys Ala Gly Ile Val Ser 
                245                 250                 255     


Phe Leu Cys Ser Pro Asp Ala Ser Tyr Val Asn Gly Glu Asn Ile Ala 
            260                 265                 270         


Val Ala Gly Tyr Ser Thr Arg Leu 
        275                 280 


<210>  3370
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  3370

Met Glu Lys Lys Cys Thr Leu Tyr Phe Leu Val Leu Leu Pro Phe Phe 
1               5                   10                  15      


Met Ile Leu Val Thr Ala Glu Leu Glu Glu Ser Pro Glu Asp Ser Ile 
            20                  25                  30          


Gln Leu Gly Val Thr Arg Asn Lys Ile Met Thr Ala Gln Tyr Glu Cys 
        35                  40                  45              


Tyr Gln Lys Ile Met Gln Asp Pro Ile Gln Gln Ala Glu Gly Val Tyr 
    50                  55                  60                  


Cys Asn Arg Thr Trp Asp Gly Trp Leu Cys Trp Asn Asp Val Ala Ala 
65                  70                  75                  80  


Gly Thr Glu Ser Met Gln Leu Cys Pro Asp Tyr Phe Gln Asp Phe Asp 
                85                  90                  95      


Pro Ser Glu Lys Val Thr Lys Ile Cys Asp Gln Asp Gly Asn Trp Phe 
            100                 105                 110         


Arg His Pro Ala Ser Asn Arg Thr Trp Thr Asn Tyr Thr Gln Cys Asn 
        115                 120                 125             


Val Asn Thr His Glu Lys Val Lys Thr Ala Leu Asn Leu Phe Tyr Leu 
    130                 135                 140                 


Thr Ile Ile Gly His Gly Leu Ser Ile Ala Ser Leu Leu Ile Ser Leu 
145                 150                 155                 160 


Gly Ile Phe Phe Tyr Phe Lys Ser Leu Ser Cys Gln Arg Ile Thr Leu 
                165                 170                 175     


His Lys Asn Leu Phe Phe Ser Phe Val Cys Asn Ser Val Val Thr Ile 
            180                 185                 190         


Ile His Leu Thr Ala Val Ala Asn Asn Gln Ala Leu Val Ala Thr Asn 
        195                 200                 205             


Pro Val Ser Cys Lys Val Ser Gln Phe Ile His Leu Tyr Leu Met Gly 
    210                 215                 220                 


Cys Asn Tyr Phe Trp Met Leu Cys Glu Gly Ile Tyr Leu His Thr Leu 
225                 230                 235                 240 


Ile Val Val Ala Val Phe Ala Glu Lys Gln His Leu Met Trp Tyr Tyr 
                245                 250                 255     


Phe Leu Gly Trp Gly Phe Pro Leu Ile Pro Ala Cys Ile His Ala Ile 
            260                 265                 270         


Ala Arg Ser Leu Tyr Tyr Asn Asp Asn Cys Trp Ile Ser Ser Asp Thr 
        275                 280                 285             


His Leu Leu Tyr Ile Ile His Gly Pro Ile Cys Ala Ala Leu Leu Val 
    290                 295                 300                 


Asn Leu Phe Phe Leu Leu Asn Ile Val Arg Val Leu Ile Thr Lys Leu 
305                 310                 315                 320 


Lys Val Thr His Gln Ala Glu Ser Asn Leu Tyr Met Lys Ala Val Arg 
                325                 330                 335     


Ala Thr Leu Ile Leu Val Pro Leu Leu Gly Ile Glu Phe Val Leu Ile 
            340                 345                 350         


Pro Trp Arg Pro Glu Gly Lys Ile Ala Glu Glu Val Tyr Asp Tyr Ile 
        355                 360                 365             


Met His Ile Leu Met His Phe Gln Gly Leu Leu Val Ser Thr Ile Phe 
    370                 375                 380                 


Cys Phe Phe Asn Gly Glu Val Gln Ala Ile Leu Arg Arg Asn Trp Asn 
385                 390                 395                 400 


Gln Tyr Lys Ile Gln Phe Gly Asn Ser Phe Ser Asn Ser Glu Ala Leu 
                405                 410                 415     


Arg Ser Ala Ser Tyr Thr Val Ser Thr Ile Ser Asp Gly Pro Gly Tyr 
            420                 425                 430         


Ser His Asp Cys Pro Ser Glu His Leu Asn Gly Lys Ser Ile His Asp 
        435                 440                 445             


Ile Glu Asn Val Leu Leu Lys Pro Glu Asn Leu Tyr Asn 
    450                 455                 460     


<210>  3371
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  3371

Met Tyr Gly Lys Ser Ser Thr Arg Ala Val Leu Leu Leu Leu Gly Ile 
1               5                   10                  15      


Gln Leu Thr Ala Leu Trp Pro Ile Ala Ala Val Glu Ile Tyr Thr Ser 
            20                  25                  30          


Arg Val Leu Glu Ala Val Asn Gly Thr Asp Ala Arg Leu Lys Cys Thr 
        35                  40                  45              


Phe Ser Ser Phe Ala Pro Val Gly Asp Ala Leu Thr Val Thr Trp Asn 
    50                  55                  60                  


Phe Arg Pro Leu Asp Gly Gly Pro Glu Gln Phe Val Phe Tyr Tyr His 
65                  70                  75                  80  


Ile Asp Pro Phe Gln Pro Met Ser Gly Arg Phe Lys Asp Arg Val Ser 
                85                  90                  95      


Trp Asp Gly Asn Pro Glu Arg Tyr Asp Ala Ser Ile Leu Leu Trp Lys 
            100                 105                 110         


Leu Gln Phe Asp Asp Asn Gly Thr Tyr Thr Cys Gln Val Lys Asn Pro 
        115                 120                 125             


Pro Asp Val Asp Gly Val Ile Gly Glu Ile Arg Leu Ser Val Val His 
    130                 135                 140                 


Thr Val Arg Phe Ser Glu Ile His Phe Leu Ala Leu Ala Ile Gly Ser 
145                 150                 155                 160 


Ala Cys Ala Leu Met Ile Ile Ile Val Ile Val Val Val Leu Phe Gln 
                165                 170                 175     


His Tyr Arg Lys Lys Arg Trp Ala Glu Arg Ala His Lys Val Val Glu 
            180                 185                 190         


Ile Lys Ser Lys Glu Glu Glu Arg Leu Asn Gln Glu Lys Lys Val Ser 
        195                 200                 205             


Val Tyr Leu Glu Asp Thr Asp 
    210                 215 


<210>  3372
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  3372

Met Glu Leu Leu Glu Glu Asp Leu Thr Cys Pro Ile Cys Cys Ser Leu 
1               5                   10                  15      


Phe Asp Asp Pro Arg Val Leu Pro Cys Ser His Asn Phe Cys Lys Lys 
            20                  25                  30          


Cys Leu Glu Gly Ile Leu Glu Gly Ser Val Arg Asn Ser Leu Trp Arg 
        35                  40                  45              


Pro Ala Pro Phe Lys Cys Pro Thr Cys Arg Lys Glu Thr Ser Ala Thr 
    50                  55                  60                  


Gly Ile Asn Ser Leu Gln Val Asn Tyr Ser Leu Lys Gly Ile Val Glu 
65                  70                  75                  80  


Lys Tyr Asn Lys Ile Lys Ile Ser Pro Lys Met Pro Val Cys Lys Gly 
                85                  90                  95      


His Leu Gly Gln Pro Leu Asn Ile Phe Cys Leu Thr Asp Met Gln Leu 
            100                 105                 110         


Ile Cys Gly Ile Cys Ala Thr Arg Gly Glu His Thr Lys His Val Phe 
        115                 120                 125             


Cys Ser Ile Glu Asp Ala Tyr Ala Gln Glu Arg Asp Ala Phe Glu Ser 
    130                 135                 140                 


Leu Phe Gln Ser Phe Glu Thr Trp Arg Arg Gly Asp Ala Leu Ser Arg 
145                 150                 155                 160 


Leu Asp Thr Leu Glu Thr Ser Lys Arg Lys Ser Leu Gln Leu Leu Thr 
                165                 170                 175     


Lys Asp Ser Asp Lys Val Lys Glu Phe Phe Glu Lys Leu Gln His Thr 
            180                 185                 190         


Leu Asp Gln Lys Lys Asn Glu Ile Leu Ser Asp Phe Glu Thr Met Lys 
        195                 200                 205             


Leu Ala Val Met Gln Ala Tyr Asp Pro Glu Ile Asn Lys Leu Asn Thr 
    210                 215                 220                 


Ile Leu Gln Glu Gln Arg Met Ala Phe Asn Ile Ala Glu Ala Phe Lys 
225                 230                 235                 240 


Asp Val Ser Glu Pro Ile Val Phe Leu Gln Gln Met Gln Glu Phe Arg 
                245                 250                 255     


Glu Lys Ile Lys Val Ile Lys Glu Thr Pro Leu Pro Pro Ser Asn Leu 
            260                 265                 270         


Pro Ala Ser Pro Leu Met Lys Asn Phe Asp Thr Ser Gln Trp Glu Asp 
        275                 280                 285             


Ile Lys Leu Val Asp Val Asp Lys Leu Ser Leu Pro Gln Asp Thr Gly 
    290                 295                 300                 


Thr Phe Ile Ser Lys Ile Pro Trp Ser Phe Tyr Lys Leu Phe Leu Leu 
305                 310                 315                 320 


Ile Leu Leu Leu Gly Leu Val Ile Val Phe Gly Pro Thr Met Phe Leu 
                325                 330                 335     


Glu Trp Ser Leu Phe Asp Asp Leu Ala Thr Trp Lys Gly Cys Leu Ser 
            340                 345                 350         


Asn Phe Ser Ser Tyr Leu Thr Lys Thr Ala Asp Phe Ile Glu Gln Ser 
        355                 360                 365             


Val Phe Tyr Trp Glu Gln Val Thr Asp Gly Phe Phe Ile Phe Asn Glu 
    370                 375                 380                 


Arg Phe Lys Asn Phe Thr Leu Val Val Leu Asn Asn Val Ala Glu Phe 
385                 390                 395                 400 


Val Cys Lys Tyr Lys Leu Leu 
                405         


<210>  3373
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  3373

Met Thr Asp Ser Val Ile Tyr Ser Met Leu Glu Leu Pro Thr Ala Thr 
1               5                   10                  15      


Gln Ala Gln Asn Asp Tyr Gly Pro Gln Gln Lys Ser Ser Ser Ser Arg 
            20                  25                  30          


Pro Ser Cys Ser Cys Leu Val Ala Ile Ala Leu Gly Leu Leu Thr Ala 
        35                  40                  45              


Val Leu Leu Ser Val Leu Leu Tyr Gln Trp Ile Leu Cys Gln Gly Ser 
    50                  55                  60                  


Asn Tyr Ser Thr Cys Ala Ser Cys Pro Ser Cys Pro Asp Arg Trp Met 
65                  70                  75                  80  


Lys Tyr Gly Asn His Cys Tyr Tyr Phe Ser Val Glu Glu Lys Asp Trp 
                85                  90                  95      


Asn Ser Ser Leu Glu Phe Cys Leu Ala Arg Asp Ser His Leu Leu Val 
            100                 105                 110         


Ile Thr Asp Asn Gln Glu Met Ser Leu Leu Gln Val Phe Leu Ser Glu 
        115                 120                 125             


Ala Phe Cys Trp Ile Gly Leu Arg Asn Asn Ser Gly Trp Arg Trp Glu 
    130                 135                 140                 


Asp Gly Ser Pro Leu Asn Phe Ser Arg Ile Ser Ser Asn Ser Phe Val 
145                 150                 155                 160 


Gln Thr Cys Gly Ala Ile Asn Lys Asn Gly Leu Gln Ala Ser Ser Cys 
                165                 170                 175     


Glu Val Pro Leu His Trp Val Cys Lys Lys Val Arg Leu 
            180                 185                 


<210>  3374
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  3374

Met Val Gly Lys Met Trp Pro Val Leu Trp Thr Leu Cys Ala Val Arg 
1               5                   10                  15      


Val Thr Val Asp Ala Ile Ser Val Glu Thr Pro Gln Asp Val Leu Arg 
            20                  25                  30          


Ala Ser Gln Gly Lys Ser Val Thr Leu Pro Cys Thr Tyr His Thr Ser 
        35                  40                  45              


Thr Ser Ser Arg Glu Gly Leu Ile Gln Trp Asp Lys Leu Leu Leu Thr 
    50                  55                  60                  


His Thr Glu Arg Val Val Ile Trp Pro Phe Ser Asn Lys Asn Tyr Ile 
65                  70                  75                  80  


His Gly Glu Leu Tyr Lys Asn Arg Val Ser Ile Ser Asn Asn Ala Glu 
                85                  90                  95      


Gln Ser Asp Ala Ser Ile Thr Ile Asp Gln Leu Thr Met Ala Asp Asn 
            100                 105                 110         


Gly Thr Tyr Glu Cys Ser Val Ser Leu Met Ser Asp Leu Glu Gly Asn 
        115                 120                 125             


Thr Lys Ser Arg Val Arg Leu Leu Val Leu Val Pro Pro Ser Lys Pro 
    130                 135                 140                 


Glu Cys Gly Ile Glu Gly Glu Thr Ile Ile Gly Asn Asn Ile Gln Leu 
145                 150                 155                 160 


Thr Cys Gln Ser Lys Glu Gly Ser Pro Thr Pro Gln Tyr Ser Trp Lys 
                165                 170                 175     


Arg Tyr Asn Ile Leu Asn Gln Glu Gln Pro Leu Ala Gln Pro Ala Ser 
            180                 185                 190         


Gly Gln Pro Val Ser Leu Lys Asn Ile Ser Thr Asp Thr Ser Gly Tyr 
        195                 200                 205             


Tyr Ile Cys Thr Ser Ser Asn Glu Glu Gly Thr Gln Phe Cys Asn Ile 
    210                 215                 220                 


Thr Val Ala Val Arg Ser Pro Ser Met Asn Val Ala Leu Tyr Val Gly 
225                 230                 235                 240 


Ile Ala Val Gly Val Val Ala Ala Leu Ile Ile Ile Gly Ile Ile Ile 
                245                 250                 255     


Tyr Cys Cys Cys Cys Arg Gly Lys Asp Asp Asn Thr Glu Asp Lys Glu 
            260                 265                 270         


Asp Ala Arg Pro Asn Arg Glu Ala Tyr Glu Glu Pro Pro Glu Gln Leu 
        275                 280                 285             


Arg Glu Leu Ser Arg Glu Arg Glu Glu Glu Asp Asp Tyr Arg Gln Glu 
    290                 295                 300                 


Glu Gln Arg Ser Thr Gly Arg Glu Ser Pro Asp His Leu Asp Gln 
305                 310                 315                 


<210>  3375
<211>  569
<212>  PRT
<213>  Homo sapiens

<400>  3375

Met Glu Lys Lys Trp Lys Tyr Cys Ala Val Tyr Tyr Ile Ile Gln Ile 
1               5                   10                  15      


His Phe Val Lys Gly Val Trp Glu Lys Thr Val Asn Thr Glu Glu Asn 
            20                  25                  30          


Val Tyr Ala Thr Leu Gly Ser Asp Val Asn Leu Thr Cys Gln Thr Gln 
        35                  40                  45              


Thr Val Gly Phe Phe Val Gln Met Gln Trp Ser Lys Val Thr Asn Lys 
    50                  55                  60                  


Ile Asp Leu Ile Ala Val Tyr His Pro Gln Tyr Gly Phe Tyr Cys Ala 
65                  70                  75                  80  


Tyr Gly Arg Pro Cys Glu Ser Leu Val Thr Phe Thr Glu Thr Pro Glu 
                85                  90                  95      


Asn Gly Ser Lys Trp Thr Leu His Leu Arg Asn Met Ser Cys Ser Val 
            100                 105                 110         


Ser Gly Arg Tyr Glu Cys Met Leu Val Leu Tyr Pro Glu Gly Ile Gln 
        115                 120                 125             


Thr Lys Ile Tyr Asn Leu Leu Ile Gln Thr His Val Thr Ala Asp Glu 
    130                 135                 140                 


Trp Asn Ser Asn His Thr Ile Glu Ile Glu Ile Asn Gln Thr Leu Glu 
145                 150                 155                 160 


Ile Pro Cys Phe Gln Asn Ser Ser Ser Lys Ile Ser Ser Glu Phe Thr 
                165                 170                 175     


Tyr Ala Trp Ser Val Glu Asp Asn Gly Thr Gln Glu Thr Leu Ile Ser 
            180                 185                 190         


Gln Asn His Leu Ile Ser Asn Ser Thr Leu Leu Lys Asp Arg Val Lys 
        195                 200                 205             


Leu Gly Thr Asp Tyr Arg Leu His Leu Ser Pro Val Gln Ile Phe Asp 
    210                 215                 220                 


Asp Gly Arg Lys Phe Ser Cys His Ile Arg Val Gly Pro Asn Lys Ile 
225                 230                 235                 240 


Leu Arg Ser Ser Thr Thr Val Lys Val Phe Ala Lys Pro Glu Ile Pro 
                245                 250                 255     


Val Ile Val Glu Asn Asn Ser Thr Asp Val Leu Val Glu Arg Arg Phe 
            260                 265                 270         


Thr Cys Leu Leu Lys Asn Val Phe Pro Lys Ala Asn Ile Thr Trp Phe 
        275                 280                 285             


Ile Asp Gly Ser Phe Leu His Asp Glu Lys Glu Gly Ile Tyr Ile Thr 
    290                 295                 300                 


Asn Glu Glu Arg Lys Gly Lys Asp Gly Phe Leu Glu Leu Lys Ser Val 
305                 310                 315                 320 


Leu Thr Arg Val His Ser Asn Lys Pro Ala Gln Ser Asp Asn Leu Thr 
                325                 330                 335     


Ile Trp Cys Met Ala Leu Ser Pro Val Pro Gly Asn Lys Val Trp Asn 
            340                 345                 350         


Ile Ser Ser Glu Lys Ile Thr Phe Leu Leu Gly Ser Glu Ile Ser Ser 
        355                 360                 365             


Thr Asp Pro Pro Leu Ser Val Thr Glu Ser Thr Leu Asp Thr Gln Pro 
    370                 375                 380                 


Ser Pro Ala Ser Ser Val Ser Pro Ala Arg Tyr Pro Ala Thr Ser Ser 
385                 390                 395                 400 


Val Thr Leu Val Asp Val Ser Ala Leu Arg Pro Asn Thr Thr Pro Gln 
                405                 410                 415     


Pro Ser Asn Ser Ser Met Thr Thr Arg Gly Phe Asn Tyr Pro Trp Thr 
            420                 425                 430         


Ser Ser Gly Thr Asp Thr Lys Lys Ser Val Ser Arg Ile Pro Ser Glu 
        435                 440                 445             


Thr Tyr Ser Ser Ser Pro Ser Gly Ala Gly Ser Thr Leu His Asp Asn 
    450                 455                 460                 


Val Phe Thr Ser Thr Ala Arg Ala Phe Ser Glu Val Pro Thr Thr Ala 
465                 470                 475                 480 


Asn Gly Ser Thr Lys Thr Asn His Val His Ile Thr Gly Ile Val Val 
                485                 490                 495     


Asn Lys Pro Lys Asp Gly Met Ser Trp Pro Val Ile Val Ala Ala Leu 
            500                 505                 510         


Leu Phe Cys Cys Met Ile Leu Phe Gly Leu Gly Val Arg Lys Trp Cys 
        515                 520                 525             


Gln Tyr Gln Lys Glu Ile Met Glu Arg Pro Pro Pro Phe Lys Pro Pro 
    530                 535                 540                 


Pro Pro Pro Ile Lys Tyr Thr Cys Ile Gln Glu Pro Asn Glu Ser Asp 
545                 550                 555                 560 


Leu Pro Tyr His Glu Met Glu Thr Leu 
                565                 


<210>  3376
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  3376

Met Ser Met Glu Asp Pro Phe Phe Val Val Lys Gly Glu Val Gln Lys 
1               5                   10                  15      


Ala Val Asn Thr Ala Gln Gly Leu Phe Gln Arg Trp Thr Glu Leu Leu 
            20                  25                  30          


Gln Asp Pro Ser Thr Ala Thr Arg Glu Glu Ile Asp Trp Thr Thr Asn 
        35                  40                  45              


Glu Leu Arg Asn Asn Leu Arg Ser Ile Glu Trp Asp Leu Glu Asp Leu 
    50                  55                  60                  


Asp Glu Thr Ile Ser Ile Val Glu Ala Asn Pro Arg Lys Phe Asn Leu 
65                  70                  75                  80  


Asp Ala Thr Glu Leu Ser Ile Arg Lys Ala Phe Ile Thr Ser Thr Arg 
                85                  90                  95      


Gln Val Val Arg Asp Met Lys Asp Gln Met Ser Thr Ser Ser Val Gln 
            100                 105                 110         


Ala Leu Ala Glu Arg Lys Asn Arg Gln Ala Leu Leu Gly Asp Ser Gly 
        115                 120                 125             


Ser Gln Asn Trp Ser Thr Gly Thr Thr Asp Lys Tyr Gly Arg Leu Asp 
    130                 135                 140                 


Arg Glu Leu Gln Arg Ala Asn Ser His Phe Ile Glu Glu Gln Gln Ala 
145                 150                 155                 160 


Gln Gln Gln Leu Ile Val Glu Gln Gln Asp Glu Gln Leu Glu Leu Val 
                165                 170                 175     


Ser Gly Ser Ile Gly Val Leu Lys Asn Met Ser Gln Arg Ile Gly Gly 
            180                 185                 190         


Glu Leu Glu Glu Gln Ala Val Met Leu Glu Asp Phe Ser His Glu Leu 
        195                 200                 205             


Glu Ser Thr Gln Ser Arg Leu Asp Asn Val Met Lys Lys Leu Ala Lys 
    210                 215                 220                 


Val Ser His Met Thr Ser Asp Arg Arg Gln Trp Cys Ala Ile Ala Ile 
225                 230                 235                 240 


Leu Phe Ala Val Leu Leu Val Val Leu Ile Leu Phe Leu Val Leu 
                245                 250                 255 


<210>  3377
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  3377

Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              


Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  


Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  


Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      


Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         


Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             


Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 
    130                 135                 140                 


Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 
                165                 170                 175     


Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 
            180                 185                 190         


Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 
        195                 200                 205             


Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 
    210                 215                 220                 


Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 
225                 230                 235                 240 


Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 
                245                 250                 255     


Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 
            260                 265                 270         


Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 
        275                 280                 285             


Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 
    290                 295                 300                 


Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 
305                 310                 315                 320 


Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 
                325                 330                 335     


Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 
            340                 345                 350         


Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 
        355                 360                 365             


Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 
    370                 375                 380                 


Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 
385                 390                 395                 400 


Val Asn Lys Gly His Glu Met Ser Pro Gln Val Ala Thr Leu Ile Asp 
                405                 410                 415     


Arg Phe Val Lys Gly Arg Gly Gln Leu Asp Lys Asp Thr Leu Asp Thr 
            420                 425                 430         


Leu Thr Ala Phe Tyr Pro Gly Tyr Leu Cys Ser Leu Ser Pro Glu Glu 
        435                 440                 445             


Leu Ser Ser Val Pro Pro Ser Ser Ile Trp Ala Val Arg Pro Gln Asp 
    450                 455                 460                 


Leu Asp Thr Cys Asp Pro Arg Gln Leu Asp Val Leu Tyr Pro Lys Ala 
465                 470                 475                 480 


Arg Leu Ala Phe Gln Asn Met Asn Gly Ser Glu Tyr Phe Val Lys Ile 
                485                 490                 495     


Gln Ser Phe Leu Gly Gly Ala Pro Thr Glu Asp Leu Lys Ala Leu Ser 
            500                 505                 510         


Gln Gln Asn Val Ser Met Asp Leu Ala Thr Phe Met Lys Leu Arg Thr 
        515                 520                 525             


Asp Ala Val Leu Pro Leu Thr Val Ala Glu Val Gln Lys Leu Leu Gly 
    530                 535                 540                 


Pro His Val Glu Gly Leu Lys Ala Glu Glu Arg His Arg Pro Val Arg 
545                 550                 555                 560 


Asp Trp Ile Leu Arg Gln Arg Gln Asp Asp Leu Asp Thr Leu Gly Leu 
                565                 570                 575     


Gly Leu Gln Gly Gly Ile Pro Asn Gly Tyr Leu Val Leu Asp Leu Ser 
            580                 585                 590         


Met Gln Glu Ala Leu Ser Gly Thr Pro Cys Leu Leu Gly Pro Gly Pro 
        595                 600                 605             


Val Leu Thr Val Leu Ala Leu Leu Leu Ala Ser Thr Leu Ala 
    610                 615                 620         


<210>  3378
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  3378

Met Arg Pro Leu Pro Pro Val Gly Asp Val Arg Leu Glu Leu Ser Pro 
1               5                   10                  15      


Pro Pro Pro Leu Leu Pro Val Pro Val Val Ser Gly Ser Pro Val Gly 
            20                  25                  30          


Ser Ser Gly Arg Leu Met Ala Ser Ser Ser Ser Leu Val Pro Asp Arg 
        35                  40                  45              


Leu Arg Leu Pro Leu Cys Phe Leu Gly Val Phe Val Cys Tyr Phe Tyr 
    50                  55                  60                  


Tyr Gly Ile Leu Gln Glu Lys Ile Thr Arg Gly Lys Tyr Gly Glu Gly 
65                  70                  75                  80  


Ala Lys Gln Glu Thr Phe Thr Phe Ala Leu Thr Leu Val Phe Ile Gln 
                85                  90                  95      


Cys Val Ile Asn Ala Val Phe Ala Lys Ile Leu Ile Gln Phe Phe Asp 
            100                 105                 110         


Thr Ala Arg Val Asp Arg Thr Arg Ser Trp Leu Tyr Ala Ala Cys Ser 
        115                 120                 125             


Ile Ser Tyr Leu Gly Ala Met Val Ser Ser Asn Ser Ala Leu Gln Phe 
    130                 135                 140                 


Val Asn Tyr Pro Thr Gln Val Leu Gly Lys Ser Cys Lys Pro Ile Pro 
145                 150                 155                 160 


Val Met Leu Leu Gly Val Thr Leu Leu Lys Lys Lys Tyr Pro Leu Ala 
                165                 170                 175     


Lys Tyr Leu Cys Val Leu Leu Ile Val Ala Gly Val Ala Leu Phe Met 
            180                 185                 190         


Tyr Lys Pro Lys Lys Val Val Gly Ile Glu Glu His Thr Val Gly Tyr 
        195                 200                 205             


Gly Glu Leu Leu Leu Leu Leu Ser Leu Thr Leu Asp Gly Leu Thr Gly 
    210                 215                 220                 


Val Ser Gln Asp His Met Arg Ala His Tyr Gln Thr Gly Ser Asn His 
225                 230                 235                 240 


Met Met Leu Asn Ile Asn Leu Trp Ser Thr Leu Leu Leu Gly Met Gly 
                245                 250                 255     


Ile Leu Phe Thr Gly Glu Leu Trp Glu Phe Leu Ser Phe Ala Glu Arg 
            260                 265                 270         


Tyr Pro Ala Ile Ile Tyr Asn Ile Leu Leu Phe Gly Leu Thr Ser Ala 
        275                 280                 285             


Leu Gly Gln Ser Phe Ile Phe Met Thr Val Val Tyr Phe Gly Pro Leu 
    290                 295                 300                 


Thr Cys Ser Ile Ile Thr Thr Thr Arg Lys Phe Phe Thr Ile Leu Ala 
305                 310                 315                 320 


Ser Val Ile Leu Phe Ala Asn Pro Ile Ser Pro Met Gln Trp Val Gly 
                325                 330                 335     


Thr Val Leu Val Phe Leu Gly Leu Gly Leu Asp Ala Lys Phe Gly Lys 
            340                 345                 350         


Gly Ala Lys Lys Thr Ser His 
        355                 


<210>  3379
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  3379

Met Phe Ile Trp Thr Ser Gly Arg Thr Ser Ser Ser Tyr Arg His Asp 
1               5                   10                  15      


Glu Lys Arg Asn Ile Tyr Gln Lys Ile Arg Asp His Asp Leu Leu Asp 
            20                  25                  30          


Lys Arg Lys Thr Val Thr Ala Leu Lys Ala Gly Glu Asp Arg Ala Ile 
        35                  40                  45              


Leu Leu Gly Leu Ala Met Met Val Cys Ser Ile Met Met Tyr Phe Leu 
    50                  55                  60                  


Leu Gly Ile Thr Leu Leu Arg Ser Tyr Met Gln Ser Val Trp Thr Glu 
65                  70                  75                  80  


Glu Ser Gln Cys Thr Leu Leu Asn Ala Ser Ile Thr Glu Thr Phe Asn 
                85                  90                  95      


Cys Ser Phe Ser Cys Gly Pro Asp Cys Trp Lys Leu Ser Gln Tyr Pro 
            100                 105                 110         


Cys Leu Gln Val Tyr Val Asn Leu Thr Ser Ser Gly Glu Lys Leu Leu 
        115                 120                 125             


Leu Tyr His Thr Glu Glu Thr Ile Lys Ile Asn Gln Lys Cys Ser Tyr 
    130                 135                 140                 


Ile Pro Lys Cys Gly Lys Asn Phe Glu Glu Ser Met Ser Leu Val Asn 
145                 150                 155                 160 


Val Val Met Glu Asn Phe Arg Lys Tyr Gln His Phe Ser Cys Tyr Ser 
                165                 170                 175     


Asp Pro Glu Gly Asn Gln Lys Ser Val Ile Leu Thr Lys Leu Tyr Ser 
            180                 185                 190         


Ser Asn Val Leu Phe His Ser Leu Phe Trp Pro Thr Cys Met Met Ala 
        195                 200                 205             


Gly Gly Val Ala Ile Val Ala Met Val Lys Leu Thr Gln Tyr Leu Ser 
    210                 215                 220                 


Leu Leu Cys Glu Arg Ile Gln Arg Ile Asn Arg 
225                 230                 235 


<210>  3380
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  3380

Met Glu Glu Tyr Ala Arg Glu Pro Cys Pro Trp Arg Ile Val Asp Asp 
1               5                   10                  15      


Cys Gly Gly Ala Phe Thr Met Gly Val Ile Gly Gly Gly Val Phe Gln 
            20                  25                  30          


Ala Ile Lys Gly Phe Arg Asn Ala Pro Val Gly Ile Arg His Arg Leu 
        35                  40                  45              


Arg Gly Ser Ala Asn Ala Val Arg Ile Arg Ala Pro Gln Ile Gly Gly 
    50                  55                  60                  


Ser Phe Ala Val Trp Gly Gly Leu Phe Ser Thr Ile Asp Cys Gly Leu 
65                  70                  75                  80  


Val Arg Leu Arg Gly Lys Glu Asp Pro Trp Asn Ser Ile Thr Ser Gly 
                85                  90                  95      


Ala Leu Thr Gly Ala Val Leu Ala Ala Arg Ser Gly Pro Leu Ala Met 
            100                 105                 110         


Val Gly Ser Ala Met Met Gly Gly Ile Leu Leu Ala Leu Ile Glu Gly 
        115                 120                 125             


Val Gly Ile Leu Leu Thr Arg Tyr Thr Ala Gln Gln Phe Arg Asn Ala 
    130                 135                 140                 


Pro Pro Phe Leu Glu Asp Pro Ser Gln Leu Pro Pro Lys Asp Gly Thr 
145                 150                 155                 160 


Pro Ala Pro Gly Tyr Pro Ser Tyr Gln Gln Tyr His 
                165                 170         


<210>  3381
<211>  436
<212>  PRT
<213>  Homo sapiens

<400>  3381

Met Asp Gly Lys Pro Ala Thr Arg Lys Gly Pro Asp Phe Cys Ser Leu 
1               5                   10                  15      


Arg Tyr Gly Leu Ala Leu Ile Met His Phe Ser Asn Phe Thr Met Ile 
            20                  25                  30          


Thr Gln Arg Val Ser Leu Ser Ile Ala Ile Ile Ala Met Val Asn Thr 
        35                  40                  45              


Thr Gln Gln Gln Gly Leu Ser Asn Ala Ser Thr Glu Gly Pro Val Ala 
    50                  55                  60                  


Asp Ala Phe Asn Asn Ser Ser Ile Ser Ile Lys Glu Phe Asp Thr Lys 
65                  70                  75                  80  


Ala Ser Val Tyr Gln Trp Ser Pro Glu Thr Gln Gly Ile Ile Phe Ser 
                85                  90                  95      


Ser Ile Asn Tyr Gly Ile Ile Leu Thr Leu Ile Pro Ser Gly Tyr Leu 
            100                 105                 110         


Ala Gly Ile Phe Gly Ala Lys Lys Met Leu Gly Ala Gly Leu Leu Ile 
        115                 120                 125             


Ser Ser Leu Leu Thr Leu Phe Thr Pro Leu Ala Ala Asp Phe Gly Val 
    130                 135                 140                 


Ile Leu Val Ile Met Val Arg Thr Val Gln Gly Met Ala Gln Gly Met 
145                 150                 155                 160 


Ala Trp Thr Gly Gln Phe Thr Ile Trp Ala Lys Trp Ala Pro Pro Leu 
                165                 170                 175     


Glu Arg Ser Lys Leu Thr Thr Ile Ala Gly Ser Gly Ser Ala Phe Gly 
            180                 185                 190         


Ser Phe Ile Ile Leu Cys Val Gly Gly Leu Ile Ser Gln Ala Leu Ser 
        195                 200                 205             


Trp Pro Phe Ile Phe Tyr Ile Phe Gly Ser Thr Gly Cys Val Cys Cys 
    210                 215                 220                 


Leu Leu Trp Phe Thr Val Ile Tyr Asp Asp Pro Met His His Pro Cys 
225                 230                 235                 240 


Ile Ser Val Arg Glu Lys Glu His Ile Leu Ser Ser Leu Ala Gln Gln 
                245                 250                 255     


Pro Ser Ser Pro Gly Arg Ala Val Pro Ile Lys Ala Met Val Thr Cys 
            260                 265                 270         


Leu Pro Leu Trp Ala Ile Phe Leu Gly Phe Phe Ser His Phe Trp Leu 
        275                 280                 285             


Cys Thr Ile Ile Leu Thr Tyr Leu Pro Thr Tyr Ile Ser Thr Leu Leu 
    290                 295                 300                 


His Val Asn Ile Arg Asp Ser Gly Val Leu Ser Ser Leu Pro Phe Ile 
305                 310                 315                 320 


Ala Ala Ala Ser Cys Thr Ile Leu Gly Gly Gln Leu Ala Asp Phe Leu 
                325                 330                 335     


Leu Ser Arg Asn Leu Leu Arg Leu Ile Thr Val Arg Lys Leu Phe Ser 
            340                 345                 350         


Ser Leu Asp Met Gln Val Ser Ser Trp Glu Ser Gln Gly Asp Leu Gly 
        355                 360                 365             


Ser Ser Gln Glu Ser Ser Leu Pro Leu Pro Leu Asp Ser Ser Ser Val 
    370                 375                 380                 


Arg Ile Leu Ser Leu Val Gly Gly Met Ser Phe Ser Cys Leu Leu Gln 
385                 390                 395                 400 


Ser Thr Cys Leu Ala Trp Ser Phe Thr Ser Arg Leu Asp Lys Gln Asn 
                405                 410                 415     


Phe Lys Thr Gly Pro Lys Arg Gly Pro Leu Pro Ala Ser Glu Asp Ile 
            420                 425                 430         


Lys Leu Gln Thr 
        435     


<210>  3382
<211>  1325
<212>  PRT
<213>  Homo sapiens

<400>  3382

Met Leu Pro Val Tyr Gln Glu Val Lys Pro Asn Pro Leu Gln Asp Ala 
1               5                   10                  15      


Asn Leu Cys Ser Arg Val Phe Phe Trp Trp Leu Asn Pro Leu Phe Lys 
            20                  25                  30          


Ile Gly His Lys Arg Arg Leu Glu Glu Asp Asp Met Tyr Ser Val Leu 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln His Leu Gly Glu Glu Leu Gln Gly Phe Trp 
    50                  55                  60                  


Asp Lys Glu Val Leu Arg Ala Glu Asn Asp Ala Gln Lys Pro Ser Leu 
65                  70                  75                  80  


Thr Arg Ala Ile Ile Lys Cys Tyr Trp Lys Ser Tyr Leu Val Leu Gly 
                85                  90                  95      


Ile Phe Thr Leu Ile Glu Glu Ser Ala Lys Val Ile Gln Pro Ile Phe 
            100                 105                 110         


Leu Gly Lys Ile Ile Asn Tyr Phe Glu Asn Tyr Asp Pro Met Asp Ser 
        115                 120                 125             


Val Ala Leu Asn Thr Ala Tyr Ala Tyr Ala Thr Val Leu Thr Phe Cys 
    130                 135                 140                 


Thr Leu Ile Leu Ala Ile Leu His His Leu Tyr Phe Tyr His Val Gln 
145                 150                 155                 160 


Cys Ala Gly Met Arg Leu Arg Val Ala Met Cys His Met Ile Tyr Arg 
                165                 170                 175     


Lys Ala Leu Arg Leu Ser Asn Met Ala Met Gly Lys Thr Thr Thr Gly 
            180                 185                 190         


Gln Ile Val Asn Leu Leu Ser Asn Asp Val Asn Lys Phe Asp Gln Val 
        195                 200                 205             


Thr Val Phe Leu His Phe Leu Trp Ala Gly Pro Leu Gln Ala Ile Ala 
    210                 215                 220                 


Val Thr Ala Leu Leu Trp Met Glu Ile Gly Ile Ser Cys Leu Ala Gly 
225                 230                 235                 240 


Met Ala Val Leu Ile Ile Leu Leu Pro Leu Gln Ser Cys Phe Gly Lys 
                245                 250                 255     


Leu Phe Ser Ser Leu Arg Ser Lys Thr Ala Thr Phe Thr Asp Ala Arg 
            260                 265                 270         


Ile Arg Thr Met Asn Glu Val Ile Thr Gly Ile Arg Ile Ile Lys Met 
        275                 280                 285             


Tyr Ala Trp Glu Lys Ser Phe Ser Asn Leu Ile Thr Asn Leu Arg Lys 
    290                 295                 300                 


Lys Glu Ile Ser Lys Ile Leu Arg Ser Ser Cys Leu Arg Gly Met Asn 
305                 310                 315                 320 


Leu Ala Ser Phe Phe Ser Ala Ser Lys Ile Ile Val Phe Val Thr Phe 
                325                 330                 335     


Thr Thr Tyr Val Leu Leu Gly Ser Val Ile Thr Ala Ser Arg Val Phe 
            340                 345                 350         


Val Ala Val Thr Leu Tyr Gly Ala Val Arg Leu Thr Val Thr Leu Phe 
        355                 360                 365             


Phe Pro Ser Ala Ile Glu Arg Val Ser Glu Ala Ile Val Ser Ile Arg 
    370                 375                 380                 


Arg Ile Gln Thr Phe Leu Leu Leu Asp Glu Ile Ser Gln Arg Asn Arg 
385                 390                 395                 400 


Gln Leu Pro Ser Asp Gly Lys Lys Met Val His Val Gln Asp Phe Thr 
                405                 410                 415     


Ala Phe Trp Asp Lys Ala Ser Glu Thr Pro Thr Leu Gln Gly Leu Ser 
            420                 425                 430         


Phe Thr Val Arg Pro Gly Glu Leu Leu Ala Val Val Gly Pro Val Gly 
        435                 440                 445             


Ala Gly Lys Ser Ser Leu Leu Ser Ala Val Leu Gly Glu Leu Ala Pro 
    450                 455                 460                 


Ser His Gly Leu Val Ser Val His Gly Arg Ile Ala Tyr Val Ser Gln 
465                 470                 475                 480 


Gln Pro Trp Val Phe Ser Gly Thr Leu Arg Ser Asn Ile Leu Phe Gly 
                485                 490                 495     


Lys Lys Tyr Glu Lys Glu Arg Tyr Glu Lys Val Ile Lys Ala Cys Ala 
            500                 505                 510         


Leu Lys Lys Asp Leu Gln Leu Leu Glu Asp Gly Asp Leu Thr Val Ile 
        515                 520                 525             


Gly Asp Arg Gly Thr Thr Leu Ser Gly Gly Gln Lys Ala Arg Val Asn 
    530                 535                 540                 


Leu Ala Arg Ala Val Tyr Gln Asp Ala Asp Ile Tyr Leu Leu Asp Asp 
545                 550                 555                 560 


Pro Leu Ser Ala Val Asp Ala Glu Val Ser Arg His Leu Phe Glu Leu 
                565                 570                 575     


Cys Ile Cys Gln Ile Leu His Glu Lys Ile Thr Ile Leu Val Thr His 
            580                 585                 590         


Gln Leu Gln Tyr Leu Lys Ala Ala Ser Gln Ile Leu Ile Leu Lys Asp 
        595                 600                 605             


Gly Lys Met Val Gln Lys Gly Thr Tyr Thr Glu Phe Leu Lys Ser Gly 
    610                 615                 620                 


Ile Asp Phe Gly Ser Leu Leu Lys Lys Asp Asn Glu Glu Ser Glu Gln 
625                 630                 635                 640 


Pro Pro Val Pro Gly Thr Pro Thr Leu Arg Asn Arg Thr Phe Ser Glu 
                645                 650                 655     


Ser Ser Val Trp Ser Gln Gln Ser Ser Arg Pro Ser Leu Lys Asp Gly 
            660                 665                 670         


Ala Leu Glu Ser Gln Asp Thr Glu Asn Val Pro Val Thr Leu Ser Glu 
        675                 680                 685             


Glu Asn Arg Ser Glu Gly Lys Val Gly Phe Gln Ala Tyr Lys Asn Tyr 
    690                 695                 700                 


Phe Arg Ala Gly Ala His Trp Ile Val Phe Ile Phe Leu Ile Leu Leu 
705                 710                 715                 720 


Asn Thr Ala Ala Gln Val Ala Tyr Val Leu Gln Asp Trp Trp Leu Ser 
                725                 730                 735     


Tyr Trp Ala Asn Lys Gln Ser Met Leu Asn Val Thr Val Asn Gly Gly 
            740                 745                 750         


Gly Asn Val Thr Glu Lys Leu Asp Leu Asn Trp Tyr Leu Gly Ile Tyr 
        755                 760                 765             


Ser Gly Leu Thr Val Ala Thr Val Leu Phe Gly Ile Ala Arg Ser Leu 
    770                 775                 780                 


Leu Val Phe Tyr Val Leu Val Asn Ser Ser Gln Thr Leu His Asn Lys 
785                 790                 795                 800 


Met Phe Glu Ser Ile Leu Lys Ala Pro Val Leu Phe Phe Asp Arg Asn 
                805                 810                 815     


Pro Ile Gly Arg Ile Leu Asn Arg Phe Ser Lys Asp Ile Gly His Leu 
            820                 825                 830         


Asp Asp Leu Leu Pro Leu Thr Phe Leu Asp Phe Ile Gln Thr Leu Leu 
        835                 840                 845             


Gln Val Val Gly Val Val Ser Val Ala Val Ala Val Ile Pro Trp Ile 
    850                 855                 860                 


Ala Ile Pro Leu Val Pro Leu Gly Ile Ile Phe Ile Phe Leu Arg Arg 
865                 870                 875                 880 


Tyr Phe Leu Glu Thr Ser Arg Asp Val Lys Arg Leu Glu Ser Thr Thr 
                885                 890                 895     


Arg Ser Pro Val Phe Ser His Leu Ser Ser Ser Leu Gln Gly Leu Trp 
            900                 905                 910         


Thr Ile Arg Ala Tyr Lys Ala Glu Glu Arg Cys Gln Glu Leu Phe Asp 
        915                 920                 925             


Ala His Gln Asp Leu His Ser Glu Ala Trp Phe Leu Phe Leu Thr Thr 
    930                 935                 940                 


Ser Arg Trp Phe Ala Val Arg Leu Asp Ala Ile Cys Ala Met Phe Val 
945                 950                 955                 960 


Ile Ile Val Ala Phe Gly Ser Leu Ile Leu Ala Lys Thr Leu Asp Ala 
                965                 970                 975     


Gly Gln Val Gly Leu Ala Leu Ser Tyr Ala Leu Thr Leu Met Gly Met 
            980                 985                 990         


Phe Gln Trp Cys Val Arg Gln Ser  Ala Glu Val Glu Asn  Met Met Ile 
        995                 1000                 1005             


Ser Val  Glu Arg Val Ile Glu  Tyr Thr Asp Leu Glu  Lys Glu Ala 
    1010                 1015                 1020             


Pro Trp  Glu Tyr Gln Lys Arg  Pro Pro Pro Ala Trp  Pro His Glu 
    1025                 1030                 1035             


Gly Val  Ile Ile Phe Asp Asn  Val Asn Phe Met Tyr  Ser Pro Gly 
    1040                 1045                 1050             


Gly Pro  Leu Val Leu Lys His  Leu Thr Ala Leu Ile  Lys Ser Gln 
    1055                 1060                 1065             


Glu Lys  Val Gly Ile Val Gly  Arg Thr Gly Ala Gly  Lys Ser Ser 
    1070                 1075                 1080             


Leu Ile  Ser Ala Leu Phe Arg  Leu Ser Glu Pro Glu  Gly Lys Ile 
    1085                 1090                 1095             


Trp Ile  Asp Lys Ile Leu Thr  Thr Glu Ile Gly Leu  His Asp Leu 
    1100                 1105                 1110             


Arg Lys  Lys Met Ser Ile Ile  Pro Gln Glu Pro Val  Leu Phe Thr 
    1115                 1120                 1125             


Gly Thr  Met Arg Lys Asn Leu  Asp Pro Phe Asn Glu  His Thr Asp 
    1130                 1135                 1140             


Glu Glu  Leu Trp Asn Ala Leu  Gln Glu Val Gln Leu  Lys Glu Thr 
    1145                 1150                 1155             


Ile Glu  Asp Leu Pro Gly Lys  Met Asp Thr Glu Leu  Ala Glu Ser 
    1160                 1165                 1170             


Gly Ser  Asn Phe Ser Val Gly  Gln Arg Gln Leu Val  Cys Leu Ala 
    1175                 1180                 1185             


Arg Ala  Ile Leu Arg Lys Asn  Gln Ile Leu Ile Ile  Asp Glu Ala 
    1190                 1195                 1200             


Thr Ala  Asn Val Asp Pro Arg  Thr Asp Glu Leu Ile  Gln Lys Lys 
    1205                 1210                 1215             


Ile Arg  Glu Lys Phe Ala His  Cys Thr Val Leu Thr  Ile Ala His 
    1220                 1225                 1230             


Arg Leu  Asn Thr Ile Ile Asp  Ser Asp Lys Ile Met  Val Leu Asp 
    1235                 1240                 1245             


Ser Gly  Arg Leu Lys Glu Tyr  Asp Glu Pro Tyr Val  Leu Leu Gln 
    1250                 1255                 1260             


Asn Lys  Glu Ser Leu Phe Tyr  Lys Met Val Gln Gln  Leu Gly Lys 
    1265                 1270                 1275             


Ala Glu  Ala Ala Ala Leu Thr  Glu Thr Ala Lys Gln  Val Tyr Phe 
    1280                 1285                 1290             


Lys Arg  Asn Tyr Pro His Ile  Gly His Thr Asp His  Met Val Thr 
    1295                 1300                 1305             


Asn Thr  Ser Asn Gly Gln Pro  Ser Thr Leu Thr Ile  Phe Glu Thr 
    1310                 1315                 1320             


Ala Leu  
    1325 


<210>  3383
<211>  598
<212>  PRT
<213>  Homo sapiens

<400>  3383

Met Arg Ala Gln Glu Asp Leu Glu Gly Arg Thr Gln His Glu Thr Thr 
1               5                   10                  15      


Arg Asp Pro Ser Thr Pro Leu Pro Thr Glu Pro Lys Phe Asp Met Leu 
            20                  25                  30          


Tyr Lys Ile Glu Asp Val Pro Pro Trp Tyr Leu Cys Ile Leu Leu Gly 
        35                  40                  45              


Phe Gln His Tyr Leu Thr Cys Phe Ser Gly Thr Ile Ala Val Pro Phe 
    50                  55                  60                  


Leu Leu Ala Glu Ala Leu Cys Val Gly His Asp Gln His Met Val Ser 
65                  70                  75                  80  


Gln Leu Ile Gly Thr Ile Phe Thr Cys Val Gly Ile Thr Thr Leu Ile 
                85                  90                  95      


Gln Thr Thr Val Gly Ile Arg Leu Pro Leu Phe Gln Ala Ser Ala Phe 
            100                 105                 110         


Ala Phe Leu Val Pro Ala Lys Ala Ile Leu Ala Leu Glu Arg Trp Lys 
        115                 120                 125             


Cys Pro Pro Glu Glu Glu Ile Tyr Gly Asn Trp Ser Leu Pro Leu Asn 
    130                 135                 140                 


Thr Ser His Ile Trp His Pro Arg Ile Arg Glu Val Gln Gly Ala Ile 
145                 150                 155                 160 


Met Val Ser Ser Val Val Glu Val Val Ile Gly Leu Leu Gly Leu Pro 
                165                 170                 175     


Gly Ala Leu Leu Asn Tyr Ile Gly Pro Leu Thr Val Thr Pro Thr Val 
            180                 185                 190         


Ser Leu Ile Gly Leu Ser Val Phe Gln Ala Ala Gly Asp Arg Ala Gly 
        195                 200                 205             


Ser His Trp Gly Ile Ser Ala Cys Ser Ile Leu Leu Ile Ile Leu Phe 
    210                 215                 220                 


Ser Gln Tyr Leu Arg Asn Leu Thr Phe Leu Leu Pro Val Tyr Arg Trp 
225                 230                 235                 240 


Gly Lys Gly Leu Thr Leu Leu Arg Ile Gln Ile Phe Lys Met Phe Pro 
                245                 250                 255     


Ile Met Leu Ala Ile Met Thr Val Trp Leu Leu Cys Tyr Val Leu Thr 
            260                 265                 270         


Leu Thr Asp Val Leu Pro Thr Asp Pro Lys Ala Tyr Gly Phe Gln Ala 
        275                 280                 285             


Arg Thr Asp Ala Arg Gly Asp Ile Met Ala Ile Ala Pro Trp Ile Arg 
    290                 295                 300                 


Ile Pro Tyr Pro Cys Gln Trp Gly Leu Pro Thr Val Thr Ala Ala Ala 
305                 310                 315                 320 


Val Leu Gly Met Phe Ser Ala Thr Leu Ala Gly Ile Ile Glu Ser Ile 
                325                 330                 335     


Gly Asp Tyr Tyr Ala Cys Ala Arg Leu Ala Gly Ala Pro Pro Pro Pro 
            340                 345                 350         


Val His Ala Ile Asn Arg Gly Ile Phe Thr Glu Gly Ile Cys Cys Ile 
        355                 360                 365             


Ile Ala Gly Leu Leu Gly Thr Gly Asn Gly Ser Thr Ser Ser Ser Pro 
    370                 375                 380                 


Asn Ile Gly Val Leu Gly Ile Thr Lys Val Gly Ser Arg Arg Val Val 
385                 390                 395                 400 


Gln Tyr Gly Ala Ala Ile Met Leu Val Leu Gly Thr Ile Gly Lys Phe 
                405                 410                 415     


Thr Ala Leu Phe Ala Ser Leu Pro Asp Pro Ile Leu Gly Gly Met Phe 
            420                 425                 430         


Cys Thr Leu Phe Gly Met Ile Thr Ala Val Gly Leu Ser Asn Leu Gln 
        435                 440                 445             


Phe Val Asp Met Asn Ser Ser Arg Asn Leu Phe Val Leu Gly Phe Ser 
    450                 455                 460                 


Met Phe Phe Gly Leu Thr Leu Pro Asn Tyr Leu Glu Ser Asn Pro Gly 
465                 470                 475                 480 


Ala Ile Asn Thr Gly Ile Leu Glu Val Asp Gln Ile Leu Ile Val Leu 
                485                 490                 495     


Leu Thr Thr Glu Met Phe Val Gly Gly Cys Leu Ala Phe Ile Leu Asp 
            500                 505                 510         


Asn Thr Val Pro Gly Ser Pro Glu Glu Arg Gly Leu Ile Gln Trp Lys 
        515                 520                 525             


Ala Gly Ala His Ala Asn Ser Asp Met Ser Ser Ser Leu Lys Ser Tyr 
    530                 535                 540                 


Asp Phe Pro Ile Gly Met Gly Ile Val Lys Arg Ile Thr Phe Leu Lys 
545                 550                 555                 560 


Tyr Ile Pro Ile Cys Pro Val Phe Lys Gly Phe Ser Ser Ser Ser Lys 
                565                 570                 575     


Asp Gln Ile Ala Ile Pro Glu Asp Thr Pro Glu Asn Thr Glu Thr Ala 
            580                 585                 590         


Ser Val Cys Thr Lys Val 
        595             


<210>  3384
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  3384

Met Gly Thr Ala Ser Arg Ser Asn Ile Ala Arg His Leu Gln Thr Asn 
1               5                   10                  15      


Leu Ile Leu Phe Cys Val Gly Ala Val Gly Ala Cys Thr Leu Ser Val 
            20                  25                  30          


Thr Gln Pro Trp Tyr Leu Glu Val Asp Tyr Thr His Glu Ala Val Thr 
        35                  40                  45              


Ile Lys Cys Thr Phe Ser Ala Thr Gly Cys Pro Ser Glu Gln Pro Thr 
    50                  55                  60                  


Cys Leu Trp Phe Arg Tyr Gly Ala His Gln Pro Glu Asn Leu Cys Leu 
65                  70                  75                  80  


Asp Gly Cys Lys Ser Glu Ala Asp Lys Phe Thr Val Arg Glu Ala Leu 
                85                  90                  95      


Lys Glu Asn Gln Val Ser Leu Thr Val Asn Arg Val Thr Ser Asn Asp 
            100                 105                 110         


Ser Ala Ile Tyr Ile Cys Gly Ile Ala Phe Pro Ser Val Pro Glu Ala 
        115                 120                 125             


Arg Ala Lys Gln Thr Gly Gly Gly Thr Thr Leu Val Val Arg Glu Ile 
    130                 135                 140                 


Lys Leu Leu Ser Lys Glu Leu Arg Ser Phe Leu Thr Ala Leu Val Ser 
145                 150                 155                 160 


Leu Leu Ser Val Tyr Val Thr Gly Val Cys Val Ala Phe Ile Leu Leu 
                165                 170                 175     


Ser Lys Ser Lys Ser Asn Pro Leu Arg Asn Lys Glu Ile Lys Glu Asp 
            180                 185                 190         


Ser Gln Lys Lys Lys Ser Ala Arg Arg Ile Phe Gln Glu Ile Ala Gln 
        195                 200                 205             


Glu Leu Tyr His Lys Arg His Val Glu Thr Asn Gln Gln Ser Glu Lys 
    210                 215                 220                 


Asp Asn Asn Thr Tyr Glu Asn Arg Arg Val Leu Ser Asn Tyr Glu Arg 
225                 230                 235                 240 


Pro 
    


<210>  3385
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  3385

Met Ala Ser Leu Arg Val Glu Arg Ala Gly Gly Pro Arg Leu Pro Arg 
1               5                   10                  15      


Thr Arg Val Gly Arg Pro Ala Ala Leu Arg Leu Leu Leu Leu Leu Gly 
            20                  25                  30          


Ala Val Leu Asn Pro His Glu Ala Leu Ala Gln Pro Leu Pro Thr Thr 
        35                  40                  45              


Gly Thr Pro Gly Ser Glu Gly Gly Thr Val Lys Asn Tyr Glu Thr Ala 
    50                  55                  60                  


Val Gln Phe Cys Trp Asn His Tyr Lys Asp Gln Met Asp Pro Ile Glu 
65                  70                  75                  80  


Lys Asp Trp Cys Asp Trp Ala Met Ile Ser Arg Pro Tyr Ser Thr Leu 
                85                  90                  95      


Arg Asp Cys Leu Glu His Phe Ala Glu Leu Phe Asp Leu Gly Phe Pro 
            100                 105                 110         


Asn Pro Leu Ala Glu Arg Ile Ile Phe Glu Thr His Gln Ile His Phe 
        115                 120                 125             


Ala Asn Cys Ser Leu Val Gln Pro Thr Phe Ser Asp Pro Pro Glu Asp 
    130                 135                 140                 


Val Leu Leu Ala Met Ile Ile Ala Pro Ile Cys Leu Ile Pro Phe Leu 
145                 150                 155                 160 


Ile Thr Leu Val Val Trp Arg Ser Lys Asp Ser Glu Ala Gln Ala 
                165                 170                 175 


<210>  3386
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  3386

Met Ala Arg Ala Leu Cys Arg Leu Pro Arg Arg Gly Leu Trp Leu Leu 
1               5                   10                  15      


Leu Ala His His Leu Phe Met Thr Thr Ala Cys Gln Glu Ala Asn Tyr 
            20                  25                  30          


Gly Ala Leu Leu Arg Glu Leu Cys Leu Thr Gln Phe Gln Val Asp Met 
        35                  40                  45              


Glu Ala Val Gly Glu Thr Leu Trp Cys Asp Trp Gly Arg Thr Ile Arg 
    50                  55                  60                  


Ser Tyr Arg Glu Leu Ala Asp Cys Thr Trp His Met Ala Glu Lys Leu 
65                  70                  75                  80  


Gly Cys Phe Trp Pro Asn Ala Glu Val Asp Arg Phe Phe Leu Ala Val 
                85                  90                  95      


His Gly Arg Tyr Phe Arg Ser Cys Pro Ile Ser Gly Arg Ala Val Arg 
            100                 105                 110         


Asp Pro Pro Gly Ser Ile Leu Tyr Pro Phe Ile Val Val Pro Ile Thr 
        115                 120                 125             


Val Thr Leu Leu Val Thr Ala Leu Val Val Trp Gln Ser Lys Arg Thr 
    130                 135                 140                 


Glu Gly Ile Val 
145             


<210>  3387
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  3387

Met Glu Thr Gly Ala Leu Arg Arg Pro Gln Leu Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Leu Cys Gly Gly Cys Pro Arg Ala Gly Gly Cys Asn Glu Thr Gly 
            20                  25                  30          


Met Leu Glu Arg Leu Pro Leu Cys Gly Lys Ala Phe Ala Asp Met Met 
        35                  40                  45              


Gly Lys Val Asp Val Trp Lys Trp Cys Asn Leu Ser Glu Phe Ile Val 
    50                  55                  60                  


Tyr Tyr Glu Ser Phe Thr Asn Cys Thr Glu Met Glu Ala Asn Val Val 
65                  70                  75                  80  


Gly Cys Tyr Trp Pro Asn Pro Leu Ala Gln Gly Phe Ile Thr Gly Ile 
                85                  90                  95      


His Arg Gln Phe Phe Ser Asn Cys Thr Val Asp Arg Val His Leu Glu 
            100                 105                 110         


Asp Pro Pro Asp Glu Val Leu Ile Pro Leu Ile Val Ile Pro Val Val 
        115                 120                 125             


Leu Thr Val Ala Met Ala Gly Leu Val Val Trp Arg Ser Lys Arg Thr 
    130                 135                 140                 


Asp Thr Leu Leu 
145             


<210>  3388
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  3388

Met Gly Met Trp Ala Ser Leu Asp Ala Leu Trp Glu Met Pro Ala Glu 
1               5                   10                  15      


Lys Arg Ile Phe Gly Ala Val Leu Leu Phe Ser Trp Thr Val Tyr Leu 
            20                  25                  30          


Trp Glu Thr Phe Leu Ala Gln Arg Gln Arg Arg Ile Tyr Lys Thr Thr 
        35                  40                  45              


Thr His Val Pro Pro Glu Leu Gly Gln Ile Met Asp Ser Glu Thr Phe 
    50                  55                  60                  


Glu Lys Ser Arg Leu Tyr Gln Leu Asp Lys Ser Thr Phe Ser Phe Trp 
65                  70                  75                  80  


Ser Gly Leu Tyr Ser Glu Thr Glu Gly Thr Leu Ile Leu Leu Phe Gly 
                85                  90                  95      


Gly Ile Pro Tyr Leu Trp Arg Leu Ser Gly Arg Phe Cys Gly Tyr Ala 
            100                 105                 110         


Gly Phe Gly Pro Glu Tyr Glu Ile Thr Gln Ser Leu Val Phe Leu Leu 
        115                 120                 125             


Leu Ala Thr Leu Phe Ser Ala Leu Thr Gly Leu Pro Trp Ser Leu Tyr 
    130                 135                 140                 


Asn Thr Phe Val Ile Glu Glu Lys His Gly Phe Asn Gln Gln Thr Leu 
145                 150                 155                 160 


Gly Phe Phe Met Lys Asp Ala Ile Lys Lys Phe Val Val Thr Gln Cys 
                165                 170                 175     


Ile Leu Leu Pro Val Ser Ser Leu Leu Leu Tyr Ile Ile Lys Ile Gly 
            180                 185                 190         


Gly Asp Tyr Phe Phe Ile Tyr Ala Trp Leu Phe Thr Leu Val Val Ser 
        195                 200                 205             


Leu Val Leu Val Thr Ile Tyr Ala Asp Tyr Ile Ala Pro Leu Phe Asp 
    210                 215                 220                 


Lys Phe Thr Pro Leu Pro Glu Gly Lys Leu Lys Glu Glu Ile Glu Val 
225                 230                 235                 240 


Met Ala Lys Ser Ile Asp Phe Pro Leu Thr Lys Val Tyr Val Val Glu 
                245                 250                 255     


Gly Ser Lys Arg Ser Ser His Ser Asn Ala Tyr Phe Tyr Gly Phe Phe 
            260                 265                 270         


Lys Asn Lys Arg Ile Val Leu Phe Asp Thr Leu Leu Glu Glu Tyr Ser 
        275                 280                 285             


Val Leu Asn Lys Asp Ile Gln Glu Asp Ser Gly Met Glu Pro Arg Asn 
    290                 295                 300                 


Glu Glu Glu Gly Asn Ser Glu Glu Ile Lys Ala Lys Val Lys Asn Lys 
305                 310                 315                 320 


Lys Gln Gly Cys Lys Asn Glu Glu Val Leu Ala Val Leu Gly His Glu 
                325                 330                 335     


Leu Gly His Trp Lys Leu Gly His Thr Val Lys Asn Ile Ile Ile Ser 
            340                 345                 350         


Gln Met Asn Ser Phe Leu Cys Phe Phe Leu Phe Ala Val Leu Ile Gly 
        355                 360                 365             


Arg Lys Glu Leu Phe Ala Ala Phe Gly Phe Tyr Asp Ser Gln Pro Thr 
    370                 375                 380                 


Leu Ile Gly Leu Leu Ile Ile Phe Gln Phe Ile Phe Ser Pro Tyr Asn 
385                 390                 395                 400 


Glu Val Leu Ser Phe Cys Leu Thr Val Leu Ser Arg Arg Phe Glu Phe 
                405                 410                 415     


Gln Ala Asp Ala Phe Ala Lys Lys Leu Gly Lys Ala Lys Asp Leu Tyr 
            420                 425                 430         


Ser Ala Leu Ile Lys Leu Asn Lys Asp Asn Leu Gly Phe Pro Val Ser 
        435                 440                 445             


Asp Trp Leu Phe Ser Met Trp His Tyr Ser His Pro Pro Leu Leu Glu 
    450                 455                 460                 


Arg Leu Gln Ala Leu Lys Thr Met Lys Gln His 
465                 470                 475 


<210>  3389
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  3389

Met Ala Val Trp Leu Ala Gln Trp Leu Gly Pro Leu Leu Leu Val Ser 
1               5                   10                  15      


Leu Trp Gly Leu Leu Ala Pro Ala Ser Leu Leu Arg Arg Leu Gly Glu 
            20                  25                  30          


His Ile Gln Gln Phe Gln Glu Ser Ser Ala Gln Gly Leu Gly Leu Ser 
        35                  40                  45              


Leu Gly Pro Gly Ala Ala Ala Leu Pro Lys Val Gly Trp Leu Glu Gln 
    50                  55                  60                  


Leu Leu Asp Pro Phe Asn Val Ser Asp Arg Arg Ser Phe Leu Gln Arg 
65                  70                  75                  80  


Tyr Trp Val Asn Asp Gln His Trp Val Gly Gln Asp Gly Pro Ile Phe 
                85                  90                  95      


Leu His Leu Gly Gly Glu Gly Ser Leu Gly Pro Gly Ser Val Met Arg 
            100                 105                 110         


Gly His Pro Ala Ala Leu Ala Pro Ala Trp Gly Ala Leu Val Ile Ser 
        115                 120                 125             


Leu Glu His Arg Phe Tyr Gly Leu Ser Ile Pro Ala Gly Gly Leu Glu 
    130                 135                 140                 


Met Ala Gln Leu Arg Phe Leu Ser Ser Arg Leu Ala Leu Ala Asp Val 
145                 150                 155                 160 


Val Ser Ala Arg Leu Ala Leu Ser Arg Leu Phe Asn Ile Ser Ser Ser 
                165                 170                 175     


Ser Pro Trp Ile Cys Phe Gly Gly Ser Tyr Ala Gly Ser Leu Ala Ala 
            180                 185                 190         


Trp Ala Arg Leu Lys Phe Pro His Leu Ile Phe Ala Ser Val Ala Ser 
        195                 200                 205             


Ser Ala Pro Val Arg Ala Val Leu Asp Phe Ser Glu Tyr Asn Asp Val 
    210                 215                 220                 


Val Ser Arg Ser Leu Met Ser Thr Ala Ile Gly Gly Ser Leu Glu Cys 
225                 230                 235                 240 


Arg Ala Ala Val Ser Val Ala Phe Ala Glu Val Glu Arg Arg Leu Arg 
                245                 250                 255     


Ser Gly Gly Ala Ala Gln Ala Ala Leu Arg Thr Glu Leu Ser Ala Cys 
            260                 265                 270         


Gly Pro Leu Gly Arg Ala Glu Asn Gln Ala Glu Leu Leu Gly Ala Leu 
        275                 280                 285             


Gln Ala Leu Val Gly Gly Val Val Gln Tyr Asp Gly Gln Thr Gly Ala 
    290                 295                 300                 


Pro Leu Ser Val Arg Gln Leu Cys Gly Leu Leu Leu Gly Gly Gly Gly 
305                 310                 315                 320 


Asn Arg Ser His Ser Thr Pro Tyr Cys Gly Leu Arg Arg Ala Val Gln 
                325                 330                 335     


Ile Val Leu His Ser Leu Gly Gln Lys Cys Leu Ser Phe Ser Arg Ala 
            340                 345                 350         


Glu Thr Val Ala Gln Leu Arg Ser Thr Glu Pro Gln Leu Ser Gly Val 
        355                 360                 365             


Gly Asp Arg Gln Trp Leu Tyr Gln Thr Cys Thr Glu Phe Gly Phe Tyr 
    370                 375                 380                 


Val Thr Cys Glu Asn Pro Arg Cys Pro Phe Ser Gln Leu Pro Ala Leu 
385                 390                 395                 400 


Pro Ser Gln Leu Asp Leu Cys Glu Gln Val Phe Gly Leu Ser Ala Leu 
                405                 410                 415     


Ser Val Ala Gln Ala Val Ala Gln Thr Asn Ser Tyr Tyr Gly Gly Gln 
            420                 425                 430         


Thr Pro Gly Ala Asn Lys Val Leu Phe Val Asn Gly Asp Thr Asp Pro 
        435                 440                 445             


Trp His Val Leu Ser Val Thr Gln Ala Leu Gly Ser Ser Glu Ser Thr 
    450                 455                 460                 


Leu Leu Ile Arg Thr Gly Ser His Cys Leu Asp Met Ala Pro Glu Arg 
465                 470                 475                 480 


Pro Ser Asp Ser Pro Ser Leu Arg Leu Gly Arg Gln Asn Ile Phe Gln 
                485                 490                 495     


Gln Leu Gln Thr Trp Leu Lys Leu Ala Lys Glu Ser Gln Ile Lys Gly 
            500                 505                 510         


Glu Val 
        


<210>  3390
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  3390

Met Gln Trp Ala Val Gly Arg Arg Trp Ala Trp Ala Ala Leu Leu Leu 
1               5                   10                  15      


Ala Val Ala Ala Val Leu Thr Gln Val Val Trp Leu Trp Leu Gly Thr 
            20                  25                  30          


Gln Ser Phe Val Phe Gln Arg Glu Glu Ile Ala Gln Leu Ala Arg Gln 
        35                  40                  45              


Tyr Ala Gly Leu Asp His Glu Leu Ala Phe Ser Arg Leu Ile Val Glu 
    50                  55                  60                  


Leu Arg Arg Leu His Pro Gly His Val Leu Pro Asp Glu Glu Leu Gln 
65                  70                  75                  80  


Trp Val Phe Val Asn Ala Gly Gly Trp Met Gly Ala Met Cys Leu Leu 
                85                  90                  95      


His Ala Ser Leu Ser Glu Tyr Val Leu Leu Phe Gly Thr Ala Leu Gly 
            100                 105                 110         


Ser Arg Gly His Ser Gly Arg Tyr Trp Ala Glu Ile Ser Asp Thr Ile 
        115                 120                 125             


Ile Ser Gly Thr Phe His Gln Trp Arg Glu Gly Thr Thr Lys Ser Glu 
    130                 135                 140                 


Val Phe Tyr Pro Gly Glu Thr Val Val His Gly Pro Gly Glu Ala Thr 
145                 150                 155                 160 


Ala Val Glu Trp Gly Pro Asn Thr Trp Met Val Glu Tyr Gly Arg Gly 
                165                 170                 175     


Val Ile Pro Ser Thr Leu Ala Phe Ala Leu Ala Asp Thr Val Phe Ser 
            180                 185                 190         


Thr Gln Asp Phe Leu Thr Leu Phe Tyr Thr Leu Arg Ser Tyr Ala Arg 
        195                 200                 205             


Gly Leu Arg Leu Glu Leu Thr Thr Tyr Leu Phe Gly Gln Asp Pro 
    210                 215                 220             


<210>  3391
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  3391

Met Arg Arg Ala Gly Leu Gly Glu Gly Val Pro Pro Gly Asn Tyr Gly 
1               5                   10                  15      


Asn Tyr Gly Tyr Ala Asn Ser Gly Tyr Ser Ala Cys Glu Glu Glu Asn 
            20                  25                  30          


Glu Arg Leu Thr Glu Ser Leu Arg Ser Lys Val Thr Ala Ile Lys Ser 
        35                  40                  45              


Leu Ser Ile Glu Ile Gly His Glu Val Lys Thr Gln Asn Lys Leu Leu 
    50                  55                  60                  


Ala Glu Met Asp Ser Gln Phe Asp Ser Thr Thr Gly Phe Leu Gly Lys 
65                  70                  75                  80  


Thr Met Gly Lys Leu Lys Ile Leu Ser Arg Gly Ser Gln Thr Lys Leu 
                85                  90                  95      


Leu Cys Tyr Met Met Leu Phe Ser Leu Phe Val Phe Phe Ile Ile Tyr 
            100                 105                 110         


Trp Ile Ile Lys Leu Arg 
        115             


<210>  3392
<211>  598
<212>  PRT
<213>  Homo sapiens

<400>  3392

Met Thr Pro Ile Val Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr Arg Val Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Asp Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser 
        35                  40                  45              


Cys Gln Gly Ser Leu Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys 
    50                  55                  60                  


Lys Ser Ala Ser Trp Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn 
65                  70                  75                  80  


Gly Gln Phe His Ile Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr 
                85                  90                  95      


Gly Cys Gln Tyr Tyr Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro 
            100                 105                 110         


Leu Val Leu Val Met Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala 
        115                 120                 125             


Gln Pro Ser Pro Val Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys 
    130                 135                 140                 


Glu Ser Gln Val Ala Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu 
145                 150                 155                 160 


Asp Glu His Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser 
                165                 170                 175     


Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp 
            180                 185                 190         


Ser His Arg Cys Tyr Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser 
        195                 200                 205             


Ser Pro Ser Asp Leu Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys 
    210                 215                 220                 


Pro Ser Leu Ser Val Gln Pro Gly Pro Val Met Ala Pro Gly Glu Ser 
225                 230                 235                 240 


Leu Thr Leu Gln Cys Val Ser Asp Val Gly Tyr Asp Arg Phe Val Leu 
                245                 250                 255     


Tyr Lys Glu Gly Glu Arg Asp Leu Arg Gln Leu Pro Gly Arg Gln Pro 
            260                 265                 270         


Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg 
        275                 280                 285             


Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser 
    290                 295                 300                 


Glu Cys Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln 
305                 310                 315                 320 


Ile Arg Gly Thr Pro Phe Ile Ser Val Gln Pro Gly Pro Thr Val Ala 
                325                 330                 335     


Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Trp Arg Gln Phe His 
            340                 345                 350         


Thr Phe Leu Leu Thr Lys Ala Gly Ala Ala Asp Ala Pro Leu Arg Leu 
        355                 360                 365             


Arg Ser Ile His Glu Tyr Pro Lys Tyr Gln Ala Glu Phe Pro Met Ser 
    370                 375                 380                 


Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Leu 
385                 390                 395                 400 


Asn Ser Asp Pro Tyr Leu Leu Ser His Pro Ser Glu Pro Leu Glu Leu 
                405                 410                 415     


Val Val Ser Gly Pro Ser Met Gly Ser Ser Pro Pro Pro Thr Gly Pro 
            420                 425                 430         


Ile Ser Thr Pro Ala Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly 
        435                 440                 445             


Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly 
    450                 455                 460                 


Ile Leu Val Ala Val Val Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe 
465                 470                 475                 480 


Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln 
                485                 490                 495     


Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro 
            500                 505                 510         


Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln 
        515                 520                 525             


Glu Glu Asn Leu Tyr Ala Ala Val Lys Asp Thr Gln Pro Glu Asp Gly 
    530                 535                 540                 


Val Glu Met Asp Thr Arg Ala Ala Ala Ser Glu Ala Pro Gln Asp Val 
545                 550                 555                 560 


Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Lys Ala Thr Glu 
                565                 570                 575     


Pro Pro Pro Ser Gln Glu Arg Glu Pro Pro Ala Glu Pro Ser Ile Tyr 
            580                 585                 590         


Ala Thr Leu Ala Ile His 
        595             


<210>  3393
<211>  910
<212>  PRT
<213>  Homo sapiens

<400>  3393

Met Asp Thr Ala Glu Glu Asp Ile Cys Arg Val Cys Arg Ser Glu Gly 
1               5                   10                  15      


Thr Pro Glu Lys Pro Leu Tyr His Pro Cys Val Cys Thr Gly Ser Ile 
            20                  25                  30          


Lys Phe Ile His Gln Glu Cys Leu Val Gln Trp Leu Lys His Ser Arg 
        35                  40                  45              


Lys Glu Tyr Cys Glu Leu Cys Lys His Arg Phe Ala Phe Thr Pro Ile 
    50                  55                  60                  


Tyr Ser Pro Asp Met Pro Ser Arg Leu Pro Ile Gln Asp Ile Phe Ala 
65                  70                  75                  80  


Gly Leu Val Thr Ser Ile Gly Thr Ala Ile Arg Tyr Trp Phe His Tyr 
                85                  90                  95      


Thr Leu Val Ala Phe Ala Trp Leu Gly Val Val Pro Leu Thr Ala Cys 
            100                 105                 110         


Arg Ile Tyr Lys Cys Leu Phe Thr Gly Ser Val Ser Ser Leu Leu Thr 
        115                 120                 125             


Leu Pro Leu Asp Met Leu Ser Thr Glu Asn Leu Leu Ala Asp Cys Leu 
    130                 135                 140                 


Gln Gly Cys Phe Val Val Thr Cys Thr Leu Cys Ala Phe Ile Ser Leu 
145                 150                 155                 160 


Val Trp Leu Arg Glu Gln Ile Val His Gly Gly Ala Pro Ile Trp Leu 
                165                 170                 175     


Glu His Ala Ala Pro Pro Phe Asn Ala Ala Gly His His Gln Asn Glu 
            180                 185                 190         


Ala Pro Ala Gly Gly Asn Gly Ala Glu Asn Val Ala Ala Asp Gln Pro 
        195                 200                 205             


Ala Asn Pro Pro Ala Glu Asn Ala Val Val Gly Glu Asn Pro Asp Ala 
    210                 215                 220                 


Gln Asp Asp Gln Ala Glu Glu Glu Glu Glu Asp Asn Glu Glu Glu Asp 
225                 230                 235                 240 


Asp Ala Gly Val Glu Asp Ala Ala Asp Ala Asn Asn Gly Ala Gln Asp 
                245                 250                 255     


Asp Met Asn Trp Asn Ala Leu Glu Trp Asp Arg Ala Ala Glu Glu Leu 
            260                 265                 270         


Thr Trp Glu Arg Met Leu Gly Leu Asp Gly Ser Leu Val Phe Leu Glu 
        275                 280                 285             


His Val Phe Trp Val Val Ser Leu Asn Thr Leu Phe Ile Leu Val Phe 
    290                 295                 300                 


Ala Phe Cys Pro Tyr His Ile Gly His Phe Ser Leu Val Gly Leu Gly 
305                 310                 315                 320 


Phe Glu Glu His Val Gln Ala Ser His Phe Glu Gly Leu Ile Thr Thr 
                325                 330                 335     


Ile Val Gly Tyr Ile Leu Leu Ala Ile Thr Leu Ile Ile Cys His Gly 
            340                 345                 350         


Leu Ala Thr Leu Val Lys Phe His Arg Ser Arg Arg Leu Leu Gly Val 
        355                 360                 365             


Cys Tyr Ile Val Val Lys Val Ser Leu Leu Val Val Val Glu Ile Gly 
    370                 375                 380                 


Val Phe Pro Leu Ile Cys Gly Trp Trp Leu Asp Ile Cys Ser Leu Glu 
385                 390                 395                 400 


Met Phe Asp Ala Thr Leu Lys Asp Arg Glu Leu Ser Phe Gln Ser Ala 
                405                 410                 415     


Pro Gly Thr Thr Met Phe Leu His Trp Leu Val Gly Met Val Tyr Val 
            420                 425                 430         


Phe Tyr Phe Ala Ser Phe Ile Leu Leu Leu Arg Glu Val Leu Arg Pro 
        435                 440                 445             


Gly Val Leu Trp Phe Leu Arg Asn Leu Asn Asp Pro Asp Phe Asn Pro 
    450                 455                 460                 


Val Gln Glu Met Ile His Leu Pro Ile Tyr Arg His Leu Arg Arg Phe 
465                 470                 475                 480 


Ile Leu Ser Val Ile Val Phe Gly Ser Ile Val Leu Leu Met Leu Trp 
                485                 490                 495     


Leu Pro Ile Arg Ile Ile Lys Ser Val Leu Pro Asn Phe Leu Pro Tyr 
            500                 505                 510         


Asn Val Met Leu Tyr Ser Asp Ala Pro Val Ser Glu Leu Ser Leu Glu 
        515                 520                 525             


Leu Leu Leu Leu Gln Val Val Leu Pro Ala Leu Leu Glu Gln Gly His 
    530                 535                 540                 


Thr Arg Gln Trp Leu Lys Gly Leu Val Arg Ala Trp Thr Val Thr Ala 
545                 550                 555                 560 


Gly Tyr Leu Leu Asp Leu His Ser Tyr Leu Leu Gly Asp Gln Glu Glu 
                565                 570                 575     


Asn Glu Asn Ser Ala Asn Gln Gln Val Asn Asn Asn Gln His Ala Arg 
            580                 585                 590         


Asn Asn Asn Ala Ile Pro Val Val Gly Glu Gly Leu His Ala Ala His 
        595                 600                 605             


Gln Ala Ile Leu Gln Gln Gly Gly Pro Val Gly Phe Gln Pro Tyr Arg 
    610                 615                 620                 


Arg Pro Leu Asn Phe Pro Leu Arg Ile Phe Leu Leu Ile Val Phe Met 
625                 630                 635                 640 


Cys Ile Thr Leu Leu Ile Ala Ser Leu Ile Cys Leu Thr Leu Pro Val 
                645                 650                 655     


Phe Ala Gly Arg Trp Leu Met Ser Phe Trp Thr Gly Thr Ala Lys Ile 
            660                 665                 670         


His Glu Leu Tyr Thr Ala Ala Cys Gly Leu Tyr Val Cys Trp Leu Thr 
        675                 680                 685             


Ile Arg Ala Val Thr Val Met Val Ala Trp Met Pro Gln Gly Arg Arg 
    690                 695                 700                 


Val Ile Phe Gln Lys Val Lys Glu Trp Ser Leu Met Ile Met Lys Thr 
705                 710                 715                 720 


Leu Ile Val Ala Val Leu Leu Ala Gly Val Val Pro Leu Leu Leu Gly 
                725                 730                 735     


Leu Leu Phe Glu Leu Val Ile Val Ala Pro Leu Arg Val Pro Leu Asp 
            740                 745                 750         


Gln Thr Pro Leu Phe Tyr Pro Trp Gln Asp Trp Ala Leu Gly Val Leu 
        755                 760                 765             


His Ala Lys Ile Ile Ala Ala Ile Thr Leu Met Gly Pro Gln Trp Trp 
    770                 775                 780                 


Leu Lys Thr Val Ile Glu Gln Val Tyr Ala Asn Gly Ile Arg Asn Ile 
785                 790                 795                 800 


Asp Leu His Tyr Ile Val Arg Lys Leu Ala Ala Pro Val Ile Ser Val 
                805                 810                 815     


Leu Leu Leu Ser Leu Cys Val Pro Tyr Val Ile Ala Ser Gly Val Val 
            820                 825                 830         


Pro Leu Leu Gly Val Thr Ala Glu Met Gln Asn Leu Val His Arg Arg 
        835                 840                 845             


Ile Tyr Pro Phe Leu Leu Met Val Val Val Leu Met Ala Ile Leu Ser 
    850                 855                 860                 


Phe Gln Val Arg Gln Phe Lys Arg Leu Tyr Glu His Ile Lys Asn Asp 
865                 870                 875                 880 


Lys Tyr Leu Val Gly Gln Arg Leu Val Asn Tyr Glu Arg Lys Ser Gly 
                885                 890                 895     


Lys Gln Gly Ser Ser Pro Pro Pro Pro Gln Ser Ser Gln Glu 
            900                 905                 910 


<210>  3394
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  3394

Met Phe Ser Ser Val Ala His Leu Ala Arg Ala Asn Pro Phe Asn Thr 
1               5                   10                  15      


Pro His Leu Gln Leu Val His Asp Gly Leu Gly Asp Leu Arg Ser Ser 
            20                  25                  30          


Ser Pro Gly Pro Thr Gly Gln Pro Arg Arg Pro Arg Asn Leu Ala Ala 
        35                  40                  45              


Ala Ala Val Glu Glu Gln Tyr Ser Cys Asp Tyr Gly Ser Gly Arg Phe 
    50                  55                  60                  


Phe Ile Leu Cys Gly Leu Gly Gly Ile Ile Ser Cys Gly Thr Thr His 
65                  70                  75                  80  


Thr Ala Leu Val Pro Leu Asp Leu Val Lys Cys Arg Met Gln Val Asp 
                85                  90                  95      


Pro Gln Lys Tyr Lys Gly Ile Phe Asn Gly Phe Ser Val Thr Leu Lys 
            100                 105                 110         


Glu Asp Gly Val Arg Gly Leu Ala Lys Gly Trp Ala Pro Thr Phe Leu 
        115                 120                 125             


Gly Tyr Ser Met Gln Gly Leu Cys Lys Phe Gly Phe Tyr Glu Val Phe 
    130                 135                 140                 


Lys Val Leu Tyr Ser Asn Met Leu Gly Glu Glu Asn Thr Tyr Leu Trp 
145                 150                 155                 160 


Arg Thr Ser Leu Tyr Leu Ala Ala Ser Ala Ser Ala Glu Phe Phe Ala 
                165                 170                 175     


Asp Ile Ala Leu Ala Pro Met Glu Ala Ala Lys Val Arg Ile Gln Thr 
            180                 185                 190         


Gln Pro Gly Tyr Ala Asn Thr Leu Arg Asp Ala Ala Pro Lys Met Tyr 
        195                 200                 205             


Lys Glu Glu Gly Leu Lys Ala Phe Tyr Lys Gly Val Ala Pro Leu Trp 
    210                 215                 220                 


Met Arg Gln Ile Pro Tyr Thr Met Met Lys Phe Ala Cys Phe Glu Arg 
225                 230                 235                 240 


Thr Val Glu Ala Leu Tyr Lys Phe Val Val Pro Lys Pro Arg Ser Glu 
                245                 250                 255     


Cys Ser Lys Pro Glu Gln Leu Val Val Thr Phe Val Ala Gly Tyr Ile 
            260                 265                 270         


Ala Gly Val Phe Cys Ala Ile Val Ser His Pro Ala Asp Ser Val Val 
        275                 280                 285             


Ser Val Leu Asn Lys Glu Lys Gly Ser Ser Ala Ser Leu Val Leu Lys 
    290                 295                 300                 


Arg Leu Gly Phe Lys Gly Val Trp Lys Gly Leu Phe Ala Arg Ile Ile 
305                 310                 315                 320 


Met Ile Gly Thr Leu Thr Ala Leu Gln Trp Phe Ile Tyr Asp Ser Val 
                325                 330                 335     


Lys Val Tyr Phe Arg Leu Pro Arg Pro Pro Pro Pro Glu Met Pro Glu 
            340                 345                 350         


Ser Leu Lys Lys Lys Leu Gly Leu Thr Gln 
        355                 360         


<210>  3395
<211>  1100
<212>  PRT
<213>  Homo sapiens

<400>  3395

Met Gly Asn Ala Ala Gly Ser Ala Glu Gln Pro Ala Gly Pro Ala Ala 
1               5                   10                  15      


Pro Pro Pro Lys Gln Pro Ala Pro Pro Lys Gln Pro Met Pro Ala Ala 
            20                  25                  30          


Gly Glu Leu Glu Glu Arg Phe Asn Arg Ala Leu Asn Cys Met Asn Leu 
        35                  40                  45              


Pro Pro Asp Lys Val Gln Leu Leu Ser Gln Tyr Asp Asn Glu Lys Lys 
    50                  55                  60                  


Trp Glu Leu Ile Cys Asp Gln Glu Arg Phe Gln Val Lys Asn Pro Pro 
65                  70                  75                  80  


Ala Ala Tyr Ile Gln Lys Leu Lys Ser Tyr Val Asp Thr Gly Gly Val 
                85                  90                  95      


Ser Arg Lys Val Ala Ala Asp Trp Met Ser Asn Leu Gly Phe Lys Arg 
            100                 105                 110         


Arg Val Gln Glu Ser Thr Gln Val Leu Arg Glu Leu Glu Thr Ser Leu 
        115                 120                 125             


Arg Thr Asn His Ile Gly Trp Val Gln Glu Phe Leu Asn Glu Glu Asn 
    130                 135                 140                 


Arg Gly Leu Asp Val Leu Leu Glu Tyr Leu Ala Phe Ala Gln Cys Ser 
145                 150                 155                 160 


Val Thr Tyr Asp Met Glu Ser Thr Asp Asn Gly Ala Ser Asn Ser Glu 
                165                 170                 175     


Lys Asn Lys Pro Leu Glu Gln Ser Val Glu Asp Leu Ser Lys Gly Pro 
            180                 185                 190         


Pro Ser Ser Val Pro Lys Ser Arg His Leu Thr Ile Lys Leu Thr Pro 
        195                 200                 205             


Ala His Ser Arg Lys Ala Leu Arg Asn Ser Arg Ile Val Ser Gln Lys 
    210                 215                 220                 


Asp Asp Val His Val Cys Ile Met Cys Leu Arg Ala Ile Met Asn Tyr 
225                 230                 235                 240 


Gln Ser Gly Phe Ser Leu Val Met Asn His Pro Ala Cys Val Asn Glu 
                245                 250                 255     


Ile Ala Leu Ser Leu Asn Asn Lys Asn Pro Arg Thr Lys Ala Leu Val 
            260                 265                 270         


Leu Glu Leu Leu Ala Ala Val Cys Leu Val Arg Gly Gly His Asp Ile 
        275                 280                 285             


Ile Leu Ala Ala Phe Asp Asn Phe Lys Glu Val Cys Gly Glu Gln His 
    290                 295                 300                 


Arg Phe Glu Lys Leu Met Glu Tyr Phe Arg Asn Glu Asp Ser Asn Ile 
305                 310                 315                 320 


Asp Phe Met Val Ala Cys Met Gln Phe Ile Asn Ile Val Val His Ser 
                325                 330                 335     


Val Glu Asn Met Asn Phe Arg Val Phe Leu Gln Tyr Glu Phe Thr His 
            340                 345                 350         


Leu Gly Leu Asp Leu Tyr Leu Glu Arg Leu Arg Leu Thr Glu Ser Asp 
        355                 360                 365             


Lys Leu Gln Val Gln Ile Gln Ala Tyr Leu Asp Asn Ile Phe Asp Val 
    370                 375                 380                 


Gly Ala Leu Leu Glu Asp Thr Glu Thr Lys Asn Ala Val Leu Glu His 
385                 390                 395                 400 


Met Glu Glu Leu Gln Glu Gln Val Ala Leu Leu Thr Glu Arg Leu Arg 
                405                 410                 415     


Asp Ala Glu Asn Glu Ser Met Ala Lys Ile Ala Glu Leu Glu Lys Gln 
            420                 425                 430         


Leu Ser Gln Ala Arg Lys Glu Leu Glu Thr Leu Arg Glu Arg Phe Ser 
        435                 440                 445             


Glu Ser Thr Ala Met Gly Ala Ser Arg Arg Pro Pro Glu Pro Glu Lys 
    450                 455                 460                 


Ala Pro Pro Ala Ala Pro Thr Arg Pro Ser Ala Leu Glu Leu Lys Val 
465                 470                 475                 480 


Glu Glu Leu Glu Glu Lys Gly Leu Ile Arg Ile Leu Arg Gly Pro Gly 
                485                 490                 495     


Asp Ala Val Ser Ile Glu Ile Leu Pro Val Ala Val Ala Thr Pro Ser 
            500                 505                 510         


Gly Gly Asp Ala Pro Thr Pro Gly Val Pro Thr Gly Ser Pro Ser Pro 
        515                 520                 525             


Asp Leu Ala Pro Ala Ala Glu Pro Ala Pro Gly Ala Ala Pro Pro Pro 
    530                 535                 540                 


Pro Pro Pro Leu Pro Gly Leu Pro Ser Pro Gln Glu Ala Pro Pro Ser 
545                 550                 555                 560 


Ala Pro Pro Gln Ala Pro Pro Leu Pro Gly Ser Pro Glu Pro Pro Pro 
                565                 570                 575     


Ala Pro Pro Leu Pro Gly Asp Leu Pro Pro Pro Pro Pro Pro Pro Pro 
            580                 585                 590         


Pro Pro Pro Gly Thr Asp Gly Pro Val Pro Pro Pro Pro Pro Pro Pro 
        595                 600                 605             


Pro Pro Pro Pro Gly Gly Pro Pro Asp Ala Leu Gly Arg Arg Asp Ser 
    610                 615                 620                 


Glu Leu Gly Pro Gly Val Lys Ala Lys Lys Pro Ile Gln Thr Lys Phe 
625                 630                 635                 640 


Arg Met Pro Leu Leu Asn Trp Val Ala Leu Lys Pro Ser Gln Ile Thr 
                645                 650                 655     


Gly Thr Val Phe Thr Glu Leu Asn Asp Glu Lys Val Leu Gln Glu Leu 
            660                 665                 670         


Asp Met Ser Asp Phe Glu Glu Gln Phe Lys Thr Lys Ser Gln Gly Pro 
        675                 680                 685             


Ser Leu Asp Leu Ser Ala Leu Lys Ser Lys Ala Ala Gln Lys Ala Pro 
    690                 695                 700                 


Ser Lys Ala Thr Leu Ile Glu Ala Asn Arg Ala Lys Asn Leu Ala Ile 
705                 710                 715                 720 


Thr Leu Arg Lys Gly Asn Leu Gly Ala Glu Arg Ile Cys Gln Ala Ile 
                725                 730                 735     


Glu Ala Tyr Asp Leu Gln Ala Leu Gly Leu Asp Phe Leu Glu Leu Leu 
            740                 745                 750         


Met Arg Phe Leu Pro Thr Glu Tyr Glu Arg Ser Leu Ile Thr Arg Phe 
        755                 760                 765             


Glu Arg Glu Gln Arg Pro Met Glu Glu Leu Ser Glu Glu Asp Arg Phe 
    770                 775                 780                 


Met Leu Cys Phe Ser Arg Ile Pro Arg Leu Pro Glu Arg Met Thr Thr 
785                 790                 795                 800 


Leu Thr Phe Leu Gly Asn Phe Pro Asp Thr Ala Gln Leu Leu Met Pro 
                805                 810                 815     


Gln Leu Asn Ala Ile Ile Ala Ala Ser Met Ser Ile Lys Ser Ser Asp 
            820                 825                 830         


Lys Leu Arg Gln Ile Leu Glu Ile Val Leu Ala Phe Gly Asn Tyr Met 
        835                 840                 845             


Asn Ser Ser Lys Arg Gly Ala Ala Tyr Gly Phe Arg Leu Gln Ser Leu 
    850                 855                 860                 


Asp Ala Leu Leu Glu Met Lys Ser Thr Asp Arg Lys Gln Thr Leu Leu 
865                 870                 875                 880 


His Tyr Leu Val Lys Val Ile Ala Glu Lys Tyr Pro Gln Leu Thr Gly 
                885                 890                 895     


Phe His Ser Asp Leu His Phe Leu Asp Lys Ala Gly Ser Val Ser Leu 
            900                 905                 910         


Asp Ser Val Leu Ala Asp Val Arg Ser Leu Gln Arg Gly Leu Glu Leu 
        915                 920                 925             


Thr Gln Arg Glu Phe Val Arg Gln Asp Asp Cys Met Val Leu Lys Glu 
    930                 935                 940                 


Phe Leu Arg Ala Asn Ser Pro Thr Met Asp Lys Leu Leu Ala Asp Ser 
945                 950                 955                 960 


Lys Thr Ala Gln Glu Ala Phe Glu Ser Val Val Glu Tyr Phe Gly Glu 
                965                 970                 975     


Asn Pro Lys Thr Thr Ser Pro Gly Leu Phe Phe Ser Leu Phe Ser Arg 
            980                 985                 990         


Phe Ile Lys Ala Tyr Lys Lys Ala  Glu Gln Glu Val Glu  Gln Trp Lys 
        995                 1000                 1005             


Lys Glu  Ala Ala Ala Gln Glu  Ala Gly Ala Asp Thr  Pro Gly Lys 
    1010                 1015                 1020             


Gly Glu  Pro Pro Ala Pro Lys  Ser Pro Pro Lys Ala  Arg Arg Pro 
    1025                 1030                 1035             


Gln Met  Asp Leu Ile Ser Glu  Leu Lys Arg Arg Gln  Gln Lys Glu 
    1040                 1045                 1050             


Pro Leu  Ile Tyr Glu Ser Asp  Arg Asp Gly Ala Ile  Glu Asp Ile 
    1055                 1060                 1065             


Ile Thr  Val Ile Lys Thr Val  Pro Phe Thr Ala Arg  Thr Gly Lys 
    1070                 1075                 1080             


Arg Thr  Ser Arg Leu Leu Cys  Glu Ala Ser Leu Gly  Glu Glu Met 
    1085                 1090                 1095             


Pro Leu  
    1100 


<210>  3396
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  3396

Met Ser Ser Ile Leu Pro Phe Thr Pro Pro Val Val Lys Arg Leu Leu 
1               5                   10                  15      


Gly Trp Lys Lys Ser Ala Gly Gly Ser Gly Gly Ala Gly Gly Gly Glu 
            20                  25                  30          


Gln Asn Gly Gln Glu Glu Lys Trp Cys Glu Lys Ala Val Lys Ser Leu 
        35                  40                  45              


Val Lys Lys Leu Lys Lys Thr Gly Arg Leu Asp Glu Leu Glu Lys Ala 
    50                  55                  60                  


Ile Thr Thr Gln Asn Cys Asn Thr Lys Cys Val Thr Ile Pro Ser Thr 
65                  70                  75                  80  


Cys Ser Glu Ile Trp Gly Leu Ser Thr Pro Asn Thr Ile Asp Gln Trp 
                85                  90                  95      


Asp Thr Thr Gly Leu Tyr Ser Phe Ser Glu Gln Thr Arg Ser Leu Asp 
            100                 105                 110         


Gly Arg Leu Gln Val Ser His Arg Lys Gly Leu Pro His Val Ile Tyr 
        115                 120                 125             


Cys Arg Leu Trp Arg Trp Pro Asp Leu His Ser His His Glu Leu Lys 
    130                 135                 140                 


Ala Ile Glu Asn Cys Glu Tyr Ala Phe Asn Leu Lys Lys Asp Glu Val 
145                 150                 155                 160 


Cys Val Asn Pro Tyr His Tyr Gln Arg Val Glu Thr Pro Val Leu Pro 
                165                 170                 175     


Pro Val Leu Val Pro Arg His Thr Glu Ile Leu Thr Glu Leu Pro Pro 
            180                 185                 190         


Leu Asp Asp Tyr Thr His Ser Ile Pro Glu Asn Thr Asn Phe Pro Ala 
        195                 200                 205             


Gly Ile Glu Pro Gln Ser Asn Tyr Ile Pro Glu Thr Pro Pro Pro Gly 
    210                 215                 220                 


Tyr Ile Ser Glu Asp Gly Glu Thr Ser Asp Gln Gln Leu Asn Gln Ser 
225                 230                 235                 240 


Met Asp Thr Gly Ser Pro Ala Glu Leu Ser Pro Thr Thr Leu Ser Pro 
                245                 250                 255     


Val Asn His Ser Leu Asp Leu Gln Pro Val Thr Tyr Ser Glu Pro Ala 
            260                 265                 270         


Phe Trp Cys Ser Ile Ala Tyr Tyr Glu Leu Asn Gln Arg Val Gly Glu 
        275                 280                 285             


Thr Phe His Ala Ser Gln Pro Ser Leu Thr Val Asp Gly Phe Thr Asp 
    290                 295                 300                 


Pro Ser Asn Ser Glu Arg Phe Cys Leu Gly Leu Leu Ser Asn Val Asn 
305                 310                 315                 320 


Arg Asn Ala Thr Val Glu Met Thr Arg Arg His Ile Gly Arg Gly Val 
                325                 330                 335     


Arg Leu Tyr Tyr Ile Gly Gly Glu Val Phe Ala Glu Cys Leu Ser Asp 
            340                 345                 350         


Ser Ala Ile Phe Val Gln Ser Pro Asn Cys Asn Gln Arg Tyr Gly Trp 
        355                 360                 365             


His Pro Ala Thr Val Cys Lys Ile Pro Pro Gly Cys Asn Leu Lys Ile 
    370                 375                 380                 


Phe Asn Asn Gln Glu Phe Ala Ala Leu Leu Ala Gln Ser Val Asn Gln 
385                 390                 395                 400 


Gly Phe Glu Ala Val Tyr Gln Leu Thr Arg Met Cys Thr Ile Arg Met 
                405                 410                 415     


Ser Phe Val Lys Gly Trp Gly Ala Glu Tyr Arg Arg Gln Thr Val Thr 
            420                 425                 430         


Ser Thr Pro Cys Trp Ile Glu Leu His Leu Asn Gly Pro Leu Gln Trp 
        435                 440                 445             


Leu Asp Lys Val Leu Thr Gln Met Gly Ser Pro Ser Val Arg Cys Ser 
    450                 455                 460                 


Ser Met Ser 
465         


<210>  3397
<211>  653
<212>  PRT
<213>  Homo sapiens

<400>  3397

Met Pro Val Gly Gly Leu Leu Pro Leu Phe Ser Ser Pro Ala Gly Gly 
1               5                   10                  15      


Val Leu Gly Gly Gly Leu Gly Gly Gly Gly Gly Arg Lys Gly Ser Gly 
            20                  25                  30          


Pro Ala Ala Leu Arg Leu Thr Glu Lys Phe Val Leu Leu Leu Val Phe 
        35                  40                  45              


Ser Ala Phe Ile Thr Leu Cys Phe Gly Ala Ile Phe Phe Leu Pro Asp 
    50                  55                  60                  


Ser Ser Lys Leu Leu Ser Gly Val Leu Phe His Ser Ser Pro Ala Leu 
65                  70                  75                  80  


Gln Pro Ala Ala Asp His Lys Pro Gly Pro Gly Ala Arg Ala Glu Asp 
                85                  90                  95      


Ala Ala Glu Gly Arg Ala Arg Arg Arg Glu Glu Gly Ala Pro Gly Asp 
            100                 105                 110         


Pro Glu Ala Ala Leu Glu Asp Asn Leu Ala Arg Ile Arg Glu Asn His 
        115                 120                 125             


Glu Arg Ala Leu Arg Glu Ala Lys Glu Thr Leu Gln Lys Leu Pro Glu 
    130                 135                 140                 


Glu Ile Gln Arg Asp Ile Leu Leu Glu Lys Lys Lys Val Ala Gln Asp 
145                 150                 155                 160 


Gln Leu Arg Asp Lys Ala Pro Phe Arg Gly Leu Pro Pro Val Asp Phe 
                165                 170                 175     


Val Pro Pro Ile Gly Val Glu Ser Arg Glu Pro Ala Asp Ala Ala Ile 
            180                 185                 190         


Arg Glu Lys Arg Ala Lys Ile Lys Glu Met Met Lys His Ala Trp Asn 
        195                 200                 205             


Asn Tyr Lys Gly Tyr Ala Trp Gly Leu Asn Glu Leu Lys Pro Ile Ser 
    210                 215                 220                 


Lys Gly Gly His Ser Ser Ser Leu Phe Gly Asn Ile Lys Gly Ala Thr 
225                 230                 235                 240 


Ile Val Asp Ala Leu Asp Thr Leu Phe Ile Met Glu Met Lys His Glu 
                245                 250                 255     


Phe Glu Glu Ala Lys Ser Trp Val Glu Glu Asn Leu Asp Phe Asn Val 
            260                 265                 270         


Asn Ala Glu Ile Ser Val Phe Glu Val Asn Ile Arg Phe Val Gly Gly 
        275                 280                 285             


Leu Leu Ser Ala Tyr Tyr Leu Ser Gly Glu Glu Ile Phe Arg Lys Lys 
    290                 295                 300                 


Ala Val Glu Leu Gly Val Lys Leu Leu Pro Ala Phe His Thr Pro Ser 
305                 310                 315                 320 


Gly Ile Pro Trp Ala Leu Leu Asn Met Lys Ser Gly Ile Gly Arg Asn 
                325                 330                 335     


Trp Pro Trp Ala Ser Gly Gly Ser Ser Ile Leu Ala Glu Phe Gly Thr 
            340                 345                 350         


Leu His Leu Glu Phe Met His Leu Ser His Leu Ser Gly Asn Pro Ile 
        355                 360                 365             


Phe Ala Glu Lys Val Met Asn Ile Arg Thr Val Leu Asn Lys Leu Glu 
    370                 375                 380                 


Lys Pro Gln Gly Leu Tyr Pro Asn Tyr Leu Asn Pro Ser Ser Gly Gln 
385                 390                 395                 400 


Trp Gly Gln His His Val Ser Val Gly Gly Leu Gly Asp Ser Phe Tyr 
                405                 410                 415     


Glu Tyr Leu Leu Lys Ala Trp Leu Met Ser Asp Lys Thr Asp Leu Glu 
            420                 425                 430         


Ala Lys Lys Met Tyr Phe Asp Ala Val Gln Ala Ile Glu Thr His Leu 
        435                 440                 445             


Ile Arg Lys Ser Ser Ser Gly Leu Thr Tyr Ile Ala Glu Trp Lys Gly 
    450                 455                 460                 


Gly Leu Leu Glu His Lys Met Gly His Leu Thr Cys Phe Ala Gly Gly 
465                 470                 475                 480 


Met Phe Ala Leu Gly Ala Asp Ala Ala Pro Glu Gly Met Ala Gln His 
                485                 490                 495     


Tyr Leu Glu Leu Gly Ala Glu Ile Ala Arg Thr Cys His Glu Ser Tyr 
            500                 505                 510         


Asn Arg Thr Phe Met Lys Leu Gly Pro Glu Ala Phe Arg Phe Asp Gly 
        515                 520                 525             


Gly Val Glu Ala Ile Ala Thr Arg Gln Asn Glu Lys Tyr Tyr Ile Leu 
    530                 535                 540                 


Arg Pro Glu Val Met Glu Thr Tyr Met Tyr Met Trp Arg Leu Thr His 
545                 550                 555                 560 


Asp Pro Lys Tyr Arg Lys Trp Ala Trp Glu Ala Val Glu Ala Leu Glu 
                565                 570                 575     


Asn His Cys Arg Val Asn Gly Gly Tyr Ser Gly Leu Arg Asp Val Tyr 
            580                 585                 590         


Leu Leu His Glu Ser Tyr Asp Asp Val Gln Gln Ser Phe Phe Leu Ala 
        595                 600                 605             


Glu Thr Leu Lys Tyr Leu Tyr Leu Ile Phe Ser Asp Asp Asp Leu Leu 
    610                 615                 620                 


Pro Leu Glu His Trp Ile Phe Asn Ser Glu Ala His Leu Leu Pro Ile 
625                 630                 635                 640 


Leu Pro Lys Asp Lys Lys Glu Val Glu Ile Arg Glu Glu 
                645                 650             


<210>  3398
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  3398

Met Val Asn Ser Thr His Arg Gly Met His Thr Ser Leu His Leu Trp 
1               5                   10                  15      


Asn Arg Ser Ser Tyr Arg Leu His Ser Asn Ala Ser Glu Ser Leu Gly 
            20                  25                  30          


Lys Gly Tyr Ser Asp Gly Gly Cys Tyr Glu Gln Leu Phe Val Ser Pro 
        35                  40                  45              


Glu Val Phe Val Thr Leu Gly Val Ile Ser Leu Leu Glu Asn Ile Leu 
    50                  55                  60                  


Val Ile Val Ala Ile Ala Lys Asn Lys Asn Leu His Ser Pro Met Tyr 
65                  70                  75                  80  


Phe Phe Ile Cys Ser Leu Ala Val Ala Asp Met Leu Val Ser Val Ser 
                85                  90                  95      


Asn Gly Ser Glu Thr Ile Val Ile Thr Leu Leu Asn Ser Thr Asp Thr 
            100                 105                 110         


Asp Ala Gln Ser Phe Thr Val Asn Ile Asp Asn Val Ile Asp Ser Val 
        115                 120                 125             


Ile Cys Ser Ser Leu Leu Ala Ser Ile Cys Ser Leu Leu Ser Ile Ala 
    130                 135                 140                 


Val Asp Arg Tyr Phe Thr Ile Phe Tyr Ala Leu Gln Tyr His Asn Ile 
145                 150                 155                 160 


Met Thr Val Lys Arg Val Gly Ile Ile Ile Ser Cys Ile Trp Ala Ala 
                165                 170                 175     


Cys Thr Val Ser Gly Ile Leu Phe Ile Ile Tyr Ser Asp Ser Ser Ala 
            180                 185                 190         


Val Ile Ile Cys Leu Ile Thr Met Phe Phe Thr Met Leu Ala Leu Met 
        195                 200                 205             


Ala Ser Leu Tyr Val His Met Phe Leu Met Ala Arg Leu His Ile Lys 
    210                 215                 220                 


Arg Ile Ala Val Leu Pro Gly Thr Gly Ala Ile Arg Gln Gly Ala Asn 
225                 230                 235                 240 


Met Lys Gly Ala Ile Thr Leu Thr Ile Leu Ile Gly Val Phe Val Val 
                245                 250                 255     


Cys Trp Ala Pro Phe Phe Leu His Leu Ile Phe Tyr Ile Ser Cys Pro 
            260                 265                 270         


Gln Asn Pro Tyr Cys Val Cys Phe Met Ser His Phe Asn Leu Tyr Leu 
        275                 280                 285             


Ile Leu Ile Met Cys Asn Ser Ile Ile Asp Pro Leu Ile Tyr Ala Leu 
    290                 295                 300                 


Arg Ser Gln Glu Leu Arg Lys Thr Phe Lys Glu Ile Ile Cys Cys Tyr 
305                 310                 315                 320 


Pro Leu Gly Gly Leu Cys Asp Leu Ser Ser Arg Tyr 
                325                 330         


<210>  3399
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  3399

Met Asn Ser Ser Phe His Leu His Phe Leu Asp Leu Asn Leu Asn Ala 
1               5                   10                  15      


Thr Glu Gly Asn Leu Ser Gly Pro Asn Val Lys Asn Lys Ser Ser Pro 
            20                  25                  30          


Cys Glu Asp Met Gly Ile Ala Val Glu Val Phe Leu Thr Leu Gly Val 
        35                  40                  45              


Ile Ser Leu Leu Glu Asn Ile Leu Val Ile Gly Ala Ile Val Lys Asn 
    50                  55                  60                  


Lys Asn Leu His Ser Pro Met Tyr Phe Phe Val Cys Ser Leu Ala Val 
65                  70                  75                  80  


Ala Asp Met Leu Val Ser Met Ser Ser Ala Trp Glu Thr Ile Thr Ile 
                85                  90                  95      


Tyr Leu Leu Asn Asn Lys His Leu Val Ile Ala Asp Ala Phe Val Arg 
            100                 105                 110         


His Ile Asp Asn Val Phe Asp Ser Met Ile Cys Ile Ser Val Val Ala 
        115                 120                 125             


Ser Met Cys Ser Leu Leu Ala Ile Ala Val Asp Arg Tyr Val Thr Ile 
    130                 135                 140                 


Phe Tyr Ala Leu Arg Tyr His His Ile Met Thr Ala Arg Arg Ser Gly 
145                 150                 155                 160 


Ala Ile Ile Ala Gly Ile Trp Ala Phe Cys Thr Gly Cys Gly Ile Val 
                165                 170                 175     


Phe Ile Leu Tyr Ser Glu Ser Thr Tyr Val Ile Leu Cys Leu Ile Ser 
            180                 185                 190         


Met Phe Phe Ala Met Leu Phe Leu Leu Val Ser Leu Tyr Ile His Met 
        195                 200                 205             


Phe Leu Leu Ala Arg Thr His Val Lys Arg Ile Ala Ala Leu Pro Gly 
    210                 215                 220                 


Ala Ser Ser Ala Arg Gln Arg Thr Ser Met Gln Gly Ala Val Thr Val 
225                 230                 235                 240 


Thr Met Leu Leu Gly Val Phe Thr Val Cys Trp Ala Pro Phe Phe Leu 
                245                 250                 255     


His Leu Thr Leu Met Leu Ser Cys Pro Gln Asn Leu Tyr Cys Ser Arg 
            260                 265                 270         


Phe Met Ser His Phe Asn Met Tyr Leu Ile Leu Ile Met Cys Asn Ser 
        275                 280                 285             


Val Met Asp Pro Leu Ile Tyr Ala Phe Arg Ser Gln Glu Met Arg Lys 
    290                 295                 300                 


Thr Phe Lys Glu Ile Ile Cys Cys Arg Gly Phe Arg Ile Ala Cys Ser 
305                 310                 315                 320 


Phe Pro Arg Arg Asp 
                325 


<210>  3400
<211>  701
<212>  PRT
<213>  Homo sapiens

<400>  3400

Met Asp Leu Trp Asn Leu Ser Trp Phe Leu Phe Leu Asp Ala Leu Leu 
1               5                   10                  15      


Val Ile Ser Gly Leu Ala Thr Pro Glu Asn Phe Asp Val Asp Gly Gly 
            20                  25                  30          


Met Asp Gln Asp Ile Phe Asp Ile Asn Glu Gly Leu Gly Leu Asp Leu 
        35                  40                  45              


Phe Glu Gly Asp Ile Arg Leu Asp Arg Ala Gln Ile Arg Asn Ser Ile 
    50                  55                  60                  


Ile Gly Glu Lys Tyr Arg Trp Pro His Thr Ile Pro Tyr Val Leu Glu 
65                  70                  75                  80  


Asp Ser Leu Glu Met Asn Ala Lys Gly Val Ile Leu Asn Ala Phe Glu 
                85                  90                  95      


Arg Tyr Arg Leu Lys Thr Cys Ile Asp Phe Lys Pro Trp Ala Gly Glu 
            100                 105                 110         


Thr Asn Tyr Ile Ser Val Phe Lys Gly Ser Gly Cys Trp Ser Ser Val 
        115                 120                 125             


Gly Asn Arg Arg Val Gly Lys Gln Glu Leu Ser Ile Gly Ala Asn Cys 
    130                 135                 140                 


Asp Arg Ile Ala Thr Val Gln His Glu Phe Leu His Ala Leu Gly Phe 
145                 150                 155                 160 


Trp His Glu Gln Ser Arg Ser Asp Arg Asp Asp Tyr Val Arg Ile Met 
                165                 170                 175     


Trp Asp Arg Ile Leu Ser Gly Arg Glu His Asn Phe Asn Thr Tyr Ser 
            180                 185                 190         


Asp Asp Ile Ser Asp Ser Leu Asn Val Pro Tyr Asp Tyr Thr Ser Val 
        195                 200                 205             


Met His Tyr Ser Lys Thr Ala Phe Gln Asn Gly Thr Glu Pro Thr Ile 
    210                 215                 220                 


Val Thr Arg Ile Ser Asp Phe Glu Asp Val Ile Gly Gln Arg Met Asp 
225                 230                 235                 240 


Phe Ser Asp Ser Asp Leu Leu Lys Leu Asn Gln Leu Tyr Asn Cys Ser 
                245                 250                 255     


Ser Ser Leu Ser Phe Met Asp Ser Cys Ser Phe Glu Leu Glu Asn Val 
            260                 265                 270         


Cys Gly Met Ile Gln Ser Ser Gly Asp Asn Ala Asp Trp Gln Arg Val 
        275                 280                 285             


Ser Gln Val Pro Arg Gly Pro Glu Ser Asp His Ser Asn Met Gly Gln 
    290                 295                 300                 


Cys Gln Gly Ser Gly Phe Phe Met His Phe Asp Ser Ser Ser Val Asn 
305                 310                 315                 320 


Val Gly Ala Thr Ala Val Leu Glu Ser Arg Thr Leu Tyr Pro Lys Arg 
                325                 330                 335     


Gly Phe Gln Cys Leu Gln Phe Tyr Leu Tyr Asn Ser Gly Ser Glu Ser 
            340                 345                 350         


Asp Gln Leu Asn Ile Tyr Ile Arg Glu Tyr Ser Ala Asp Asn Val Asp 
        355                 360                 365             


Gly Asn Leu Thr Leu Val Glu Glu Ile Lys Glu Ile Pro Thr Gly Ser 
    370                 375                 380                 


Trp Gln Leu Tyr His Val Thr Leu Lys Val Thr Lys Lys Phe Arg Val 
385                 390                 395                 400 


Val Phe Glu Gly Arg Lys Gly Ser Gly Ala Ser Leu Gly Gly Leu Ser 
                405                 410                 415     


Ile Asp Asp Ile Asn Leu Ser Glu Thr Arg Cys Pro His His Ile Trp 
            420                 425                 430         


His Ile Arg Asn Phe Thr Gln Phe Ile Gly Ser Pro Asn Gly Thr Leu 
        435                 440                 445             


Tyr Ser Pro Pro Phe Tyr Ser Ser Lys Gly Tyr Ala Phe Gln Ile Tyr 
    450                 455                 460                 


Leu Asn Leu Ala His Val Thr Asn Ala Gly Ile Tyr Phe His Leu Ile 
465                 470                 475                 480 


Ser Gly Ala Asn Asp Asp Gln Leu Gln Trp Pro Cys Pro Trp Gln Gln 
                485                 490                 495     


Ala Thr Met Thr Leu Leu Asp Gln Asn Pro Asp Ile Arg Gln Arg Met 
            500                 505                 510         


Ser Asn Gln Arg Ser Ile Thr Thr Asp Pro Phe Met Thr Thr Asp Asn 
        515                 520                 525             


Gly Asn Tyr Phe Trp Asp Arg Pro Ser Lys Val Gly Thr Val Ala Leu 
    530                 535                 540                 


Phe Ser Asn Gly Thr Gln Phe Arg Arg Gly Gly Gly Tyr Gly Thr Ser 
545                 550                 555                 560 


Ala Phe Ile Thr His Glu Arg Leu Lys Ser Arg Asp Phe Ile Lys Gly 
                565                 570                 575     


Asp Asp Val Tyr Ile Leu Leu Thr Val Glu Asp Ile Ser His Leu Asn 
            580                 585                 590         


Ser Thr Gln Ile Gln Leu Thr Pro Ala Pro Ser Val Gln Asp Leu Cys 
        595                 600                 605             


Ser Lys Thr Thr Cys Lys Asn Asp Gly Val Cys Thr Val Arg Asp Gly 
    610                 615                 620                 


Lys Ala Glu Cys Arg Cys Gln Ser Gly Glu Asp Trp Trp Tyr Met Gly 
625                 630                 635                 640 


Glu Arg Cys Glu Lys Arg Gly Ser Thr Arg Asp Thr Ile Val Ile Ala 
                645                 650                 655     


Val Ser Ser Thr Val Ala Val Phe Ala Leu Met Leu Ile Ile Thr Leu 
            660                 665                 670         


Val Ser Val Tyr Cys Thr Arg Lys Lys Tyr Arg Glu Arg Met Ser Ser 
        675                 680                 685             


Asn Arg Pro Asn Leu Thr Pro Gln Asn Gln His Ala Phe 
    690                 695                 700     


<210>  3401
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  3401

Met Lys Leu His Cys Cys Leu Phe Thr Leu Val Ala Ser Ile Ile Val 
1               5                   10                  15      


Pro Ala Ala Phe Val Leu Glu Asp Val Asp Phe Asp Gln Met Val Ser 
            20                  25                  30          


Leu Glu Ala Asn Arg Ser Ser Tyr Asn Ala Ser Phe Pro Ser Ser Phe 
        35                  40                  45              


Glu Leu Ser Ala Ser Ser His Ser Asp Asp Asp Val Ile Ile Ala Lys 
    50                  55                  60                  


Glu Gly Thr Ser Val Ser Ile Glu Cys Leu Leu Thr Ala Ser His Tyr 
65                  70                  75                  80  


Glu Asp Val His Trp His Asn Ser Lys Gly Gln Gln Leu Asp Gly Arg 
                85                  90                  95      


Ser Arg Gly Gly Lys Trp Leu Val Ser Asp Asn Phe Leu Asn Ile Thr 
            100                 105                 110         


Asn Val Ala Phe Asp Asp Arg Gly Leu Tyr Thr Cys Phe Val Thr Ser 
        115                 120                 125             


Pro Ile Arg Ala Ser Tyr Ser Val Thr Leu Arg Val Ile Phe Thr Ser 
    130                 135                 140                 


Gly Asp Met Ser Val Tyr Tyr Met Ile Val Cys Leu Ile Ala Phe Thr 
145                 150                 155                 160 


Ile Thr Leu Ile Leu Asn Val Thr Arg Leu Cys Met Met Ser Ser His 
                165                 170                 175     


Leu Arg Lys Thr Glu Lys Ala Ile Asn Glu Phe Phe Arg Thr Glu Gly 
            180                 185                 190         


Ala Glu Lys Leu Gln Lys Ala Phe Glu Ile Ala Lys Arg Ile Pro Ile 
        195                 200                 205             


Ile Thr Ser Ala Lys Thr Leu Glu Leu Ala Lys Val Thr Gln Phe Lys 
    210                 215                 220                 


Thr Met Glu Phe Ala Arg Tyr Ile Glu Glu Leu Ala Arg Ser Val Pro 
225                 230                 235                 240 


Leu Pro Pro Leu Ile Leu Asn Cys Arg Ala Phe Val Glu Glu Met Phe 
                245                 250                 255     


Glu Ala Val Arg Val Asp Asp Pro Asp Asp Leu Gly Glu Arg Ile Lys 
            260                 265                 270         


Glu Arg Pro Ala Leu Asn Ala Gln Gly Gly Ile Tyr Val Ile Asn Pro 
        275                 280                 285             


Glu Met Gly Arg Ser Asn Ser Pro Gly Gly Asp Ser Asp Asp Gly Ser 
    290                 295                 300                 


Leu Asn Glu Gln Gly Gln Glu Ile Ala Val Gln Val Ser Val His Leu 
305                 310                 315                 320 


Gln Ser Glu Thr Lys Ser Ile Asp Thr Glu Ser Gln Gly Ser Ser His 
                325                 330                 335     


Phe Ser Pro Pro Asp Asp Ile Gly Ser Ala Glu Ser Asn Cys Asn Tyr 
            340                 345                 350         


Lys Asp Gly Ala Tyr Glu Asn Cys Gln Leu 
        355                 360         


<210>  3402
<211>  804
<212>  PRT
<213>  Homo sapiens

<400>  3402

Met Glu Glu Pro Gly Val Thr Pro Gln Pro Tyr Leu Gly Leu Leu Leu 
1               5                   10                  15      


Glu Glu Leu Arg Arg Val Val Ala Ala Leu Pro Glu Gly Met Arg Pro 
            20                  25                  30          


Asp Ser Asn Leu Tyr Gly Phe Pro Trp Glu Leu Val Ile Cys Ala Ala 
        35                  40                  45              


Val Val Gly Phe Phe Ala Val Leu Phe Phe Leu Trp Arg Ser Phe Arg 
    50                  55                  60                  


Ser Val Arg Ser Arg Leu Tyr Val Gly Arg Glu Lys Lys Leu Ala Leu 
65                  70                  75                  80  


Met Leu Ser Gly Leu Ile Glu Glu Lys Ser Lys Leu Leu Glu Lys Phe 
                85                  90                  95      


Ser Leu Val Gln Lys Glu Tyr Glu Gly Tyr Glu Val Glu Ser Ser Leu 
            100                 105                 110         


Lys Asp Ala Ser Phe Glu Lys Glu Ala Thr Glu Ala Gln Ser Leu Glu 
        115                 120                 125             


Ala Thr Cys Glu Lys Leu Asn Arg Ser Asn Ser Glu Leu Glu Asp Glu 
    130                 135                 140                 


Ile Leu Cys Leu Glu Lys Glu Leu Lys Glu Glu Lys Ser Lys His Ser 
145                 150                 155                 160 


Glu Gln Asp Glu Leu Met Ala Asp Ile Ser Lys Arg Ile Gln Ser Leu 
                165                 170                 175     


Glu Asp Glu Ser Lys Ser Leu Lys Ser Gln Val Ala Glu Ala Lys Met 
            180                 185                 190         


Thr Phe Lys Ile Phe Gln Met Asn Glu Glu Arg Leu Lys Ile Ala Ile 
        195                 200                 205             


Lys Asp Ala Leu Asn Glu Asn Ser Gln Leu Gln Glu Ser Gln Lys Gln 
    210                 215                 220                 


Leu Leu Gln Glu Ala Glu Val Trp Lys Glu Gln Val Ser Glu Leu Asn 
225                 230                 235                 240 


Lys Gln Lys Val Thr Phe Glu Asp Ser Lys Val His Ala Glu Gln Val 
                245                 250                 255     


Leu Asn Asp Lys Glu Ser His Ile Lys Thr Leu Thr Glu Arg Leu Leu 
            260                 265                 270         


Lys Met Lys Asp Trp Ala Ala Met Leu Gly Glu Asp Ile Thr Asp Asp 
        275                 280                 285             


Asp Asn Leu Glu Leu Glu Met Asn Ser Glu Ser Glu Asn Gly Ala Tyr 
    290                 295                 300                 


Leu Asp Asn Pro Pro Lys Gly Ala Leu Lys Lys Leu Ile His Ala Ala 
305                 310                 315                 320 


Lys Leu Asn Ala Ser Leu Lys Thr Leu Glu Gly Glu Arg Asn Gln Ile 
                325                 330                 335     


Tyr Ile Gln Leu Ser Glu Val Asp Lys Thr Lys Glu Glu Leu Thr Glu 
            340                 345                 350         


His Ile Lys Asn Leu Gln Thr Glu Gln Ala Ser Leu Gln Ser Glu Asn 
        355                 360                 365             


Thr His Phe Glu Asn Glu Asn Gln Lys Leu Gln Gln Lys Leu Lys Val 
    370                 375                 380                 


Met Thr Glu Leu Tyr Gln Glu Asn Glu Met Lys Leu His Arg Lys Leu 
385                 390                 395                 400 


Thr Val Glu Glu Asn Tyr Arg Leu Glu Lys Glu Glu Lys Leu Ser Lys 
                405                 410                 415     


Val Asp Glu Lys Ile Ser His Ala Thr Glu Glu Leu Glu Thr Tyr Arg 
            420                 425                 430         


Lys Arg Ala Lys Asp Leu Glu Glu Glu Leu Glu Arg Thr Ile His Ser 
        435                 440                 445             


Tyr Gln Gly Gln Ile Ile Ser His Glu Lys Lys Ala His Asp Asn Trp 
    450                 455                 460                 


Leu Ala Ala Arg Asn Ala Glu Arg Asn Leu Asn Asp Leu Arg Lys Glu 
465                 470                 475                 480 


Asn Ala His Asn Arg Gln Lys Leu Thr Glu Thr Glu Leu Lys Phe Glu 
                485                 490                 495     


Leu Leu Glu Lys Asp Pro Tyr Ala Leu Asp Val Pro Asn Thr Ala Phe 
            500                 505                 510         


Gly Arg Glu His Ser Pro Tyr Gly Pro Ser Pro Leu Gly Trp Pro Ser 
        515                 520                 525             


Ser Glu Thr Arg Ala Phe Leu Ser Pro Pro Thr Leu Leu Glu Gly Pro 
    530                 535                 540                 


Leu Arg Leu Ser Pro Leu Leu Pro Gly Gly Gly Gly Arg Gly Ser Arg 
545                 550                 555                 560 


Gly Pro Gly Asn Pro Leu Asp His Gln Ile Thr Asn Glu Arg Gly Glu 
                565                 570                 575     


Ser Ser Cys Asp Arg Leu Thr Asp Pro His Arg Ala Pro Ser Asp Thr 
            580                 585                 590         


Gly Ser Leu Ser Pro Pro Trp Asp Gln Asp Arg Arg Met Met Phe Pro 
        595                 600                 605             


Pro Pro Gly Gln Ser Tyr Pro Asp Ser Ala Leu Pro Pro Gln Arg Gln 
    610                 615                 620                 


Asp Arg Phe Cys Ser Asn Ser Gly Arg Leu Ser Gly Pro Ala Glu Leu 
625                 630                 635                 640 


Arg Ser Phe Asn Met Pro Ser Leu Asp Lys Met Asp Gly Ser Met Pro 
                645                 650                 655     


Ser Glu Met Glu Ser Ser Arg Asn Asp Thr Lys Asp Asp Leu Gly Asn 
            660                 665                 670         


Leu Asn Val Pro Asp Ser Ser Leu Pro Ala Glu Asn Glu Ala Thr Gly 
        675                 680                 685             


Pro Gly Phe Val Pro Pro Pro Leu Ala Pro Ile Arg Gly Pro Leu Phe 
    690                 695                 700                 


Pro Val Asp Ala Arg Gly Pro Phe Leu Arg Arg Gly Pro Pro Phe Pro 
705                 710                 715                 720 


Pro Pro Pro Pro Gly Ala Met Phe Gly Ala Ser Arg Asp Tyr Phe Pro 
                725                 730                 735     


Pro Gly Asp Phe Pro Gly Pro Pro Pro Ala Pro Phe Ala Met Arg Asn 
            740                 745                 750         


Val Tyr Pro Pro Arg Gly Phe Pro Pro Tyr Leu Pro Pro Arg Pro Gly 
        755                 760                 765             


Phe Phe Pro Pro Pro Pro His Ser Glu Gly Arg Ser Glu Phe Pro Ser 
    770                 775                 780                 


Gly Leu Ile Pro Pro Ser Asn Glu Pro Ala Thr Glu His Pro Glu Pro 
785                 790                 795                 800 


Gln Gln Glu Thr 
                


<210>  3403
<211>  607
<212>  PRT
<213>  Homo sapiens

<400>  3403

Met Ile Leu Leu Thr Phe Ser Thr Gly Arg Arg Leu Asp Phe Val His 
1               5                   10                  15      


His Ser Gly Val Phe Phe Leu Gln Thr Leu Leu Trp Ile Leu Cys Ala 
            20                  25                  30          


Thr Val Cys Gly Thr Glu Gln Tyr Phe Asn Val Glu Val Trp Leu Gln 
        35                  40                  45              


Lys Tyr Gly Tyr Leu Pro Pro Thr Asp Pro Arg Met Ser Val Leu Arg 
    50                  55                  60                  


Ser Ala Glu Thr Met Gln Ser Ala Leu Ala Ala Met Gln Gln Phe Tyr 
65                  70                  75                  80  


Gly Ile Asn Met Thr Gly Lys Val Asp Arg Asn Thr Ile Asp Trp Met 
                85                  90                  95      


Lys Lys Pro Arg Cys Gly Val Pro Asp Gln Thr Arg Gly Ser Ser Lys 
            100                 105                 110         


Phe His Ile Arg Arg Lys Arg Tyr Ala Leu Thr Gly Gln Lys Trp Gln 
        115                 120                 125             


His Lys His Ile Thr Tyr Ser Ile Lys Asn Val Thr Pro Lys Val Gly 
    130                 135                 140                 


Asp Pro Glu Thr Arg Lys Ala Ile Arg Arg Ala Phe Asp Val Trp Gln 
145                 150                 155                 160 


Asn Val Thr Pro Leu Thr Phe Glu Glu Val Pro Tyr Ser Glu Leu Glu 
                165                 170                 175     


Asn Gly Lys Arg Asp Val Asp Ile Thr Ile Ile Phe Ala Ser Gly Phe 
            180                 185                 190         


His Gly Asp Ser Ser Pro Phe Asp Gly Glu Gly Gly Phe Leu Ala His 
        195                 200                 205             


Ala Tyr Phe Pro Gly Pro Gly Ile Gly Gly Asp Thr His Phe Asp Ser 
    210                 215                 220                 


Asp Glu Pro Trp Thr Leu Gly Asn Pro Asn His Asp Gly Asn Asp Leu 
225                 230                 235                 240 


Phe Leu Val Ala Val His Glu Leu Gly His Ala Leu Gly Leu Glu His 
                245                 250                 255     


Ser Asn Asp Pro Thr Ala Ile Met Ala Pro Phe Tyr Gln Tyr Met Glu 
            260                 265                 270         


Thr Asp Asn Phe Lys Leu Pro Asn Asp Asp Leu Gln Gly Ile Gln Lys 
        275                 280                 285             


Ile Tyr Gly Pro Pro Asp Lys Ile Pro Pro Pro Thr Arg Pro Leu Pro 
    290                 295                 300                 


Thr Val Pro Pro His Arg Ser Ile Pro Pro Ala Asp Pro Arg Lys Asn 
305                 310                 315                 320 


Asp Arg Pro Lys Pro Pro Arg Pro Pro Thr Gly Arg Pro Ser Tyr Pro 
                325                 330                 335     


Gly Ala Lys Pro Asn Ile Cys Asp Gly Asn Phe Asn Thr Leu Ala Ile 
            340                 345                 350         


Leu Arg Arg Glu Met Phe Val Phe Lys Asp Gln Trp Phe Trp Arg Val 
        355                 360                 365             


Arg Asn Asn Arg Val Met Asp Gly Tyr Pro Met Gln Ile Thr Tyr Phe 
    370                 375                 380                 


Trp Arg Gly Leu Pro Pro Ser Ile Asp Ala Val Tyr Glu Asn Ser Asp 
385                 390                 395                 400 


Gly Asn Phe Val Phe Phe Lys Gly Asn Lys Tyr Trp Val Phe Lys Asp 
                405                 410                 415     


Thr Thr Leu Gln Pro Gly Tyr Pro His Asp Leu Ile Thr Leu Gly Ser 
            420                 425                 430         


Gly Ile Pro Pro His Gly Ile Asp Ser Ala Ile Trp Trp Glu Asp Val 
        435                 440                 445             


Gly Lys Thr Tyr Phe Phe Lys Gly Asp Arg Tyr Trp Arg Tyr Ser Glu 
    450                 455                 460                 


Glu Met Lys Thr Met Asp Pro Gly Tyr Pro Lys Pro Ile Thr Val Trp 
465                 470                 475                 480 


Lys Gly Ile Pro Glu Ser Pro Gln Gly Ala Phe Val His Lys Glu Asn 
                485                 490                 495     


Gly Phe Thr Tyr Phe Tyr Lys Gly Lys Glu Tyr Trp Lys Phe Asn Asn 
            500                 505                 510         


Gln Ile Leu Lys Val Glu Pro Gly Tyr Pro Arg Ser Ile Leu Lys Asp 
        515                 520                 525             


Phe Met Gly Cys Asp Gly Pro Thr Asp Arg Val Lys Glu Gly His Ser 
    530                 535                 540                 


Pro Pro Asp Asp Val Asp Ile Val Ile Lys Leu Asp Asn Thr Ala Ser 
545                 550                 555                 560 


Thr Val Lys Ala Ile Ala Ile Val Ile Pro Cys Ile Leu Ala Leu Cys 
                565                 570                 575     


Leu Leu Val Leu Val Tyr Thr Val Phe Gln Phe Lys Arg Lys Gly Thr 
            580                 585                 590         


Pro Arg His Ile Leu Tyr Cys Lys Arg Ser Met Gln Glu Trp Val 
        595                 600                 605         


<210>  3404
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  3404

Met Glu Arg Leu Val Ile Arg Met Pro Phe Ser His Leu Ser Thr Tyr 
1               5                   10                  15      


Ser Leu Val Trp Val Met Ala Ala Val Val Leu Cys Thr Ala Gln Val 
            20                  25                  30          


Gln Val Val Thr Gln Asp Glu Arg Glu Gln Leu Tyr Thr Pro Ala Ser 
        35                  40                  45              


Leu Lys Cys Ser Leu Gln Asn Ala Gln Glu Ala Leu Ile Val Thr Trp 
    50                  55                  60                  


Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Phe Ser Glu 
65                  70                  75                  80  


Asn His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Lys Ile Asn Ile 
                85                  90                  95      


Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile Thr Phe Trp Asn Ile Thr 
            100                 105                 110         


Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe Gly Phe 
        115                 120                 125             


Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr Val Tyr Val Gln Pro Ile 
    130                 135                 140                 


Val Ser Leu His Tyr Lys Phe Ser Glu Asp His Leu Asn Ile Thr Cys 
145                 150                 155                 160 


Ser Ala Thr Ala Arg Pro Ala Pro Met Val Phe Trp Lys Val Pro Arg 
                165                 170                 175     


Ser Gly Ile Glu Asn Ser Thr Val Thr Leu Ser His Pro Asn Gly Thr 
            180                 185                 190         


Thr Ser Val Thr Ser Ile Leu His Ile Lys Asp Pro Lys Asn Gln Val 
        195                 200                 205             


Gly Lys Glu Val Ile Cys Gln Val Leu His Leu Gly Thr Val Thr Asp 
    210                 215                 220                 


Phe Lys Gln Thr Val Asn Lys Gly Tyr Trp Phe Ser Val Pro Leu Leu 
225                 230                 235                 240 


Leu Ser Ile Val Ser Leu Val Ile Leu Leu Val Leu Ile Ser Ile Leu 
                245                 250                 255     


Leu Tyr Trp Lys Arg His Arg Asn Gln Asp Arg Glu Pro 
            260                 265                 


<210>  3405
<211>  935
<212>  PRT
<213>  Homo sapiens

<400>  3405

Met Ala Pro Ala Glu Ile Leu Asn Gly Lys Glu Ile Ser Ala Gln Ile 
1               5                   10                  15      


Arg Ala Arg Leu Lys Asn Gln Val Thr Gln Leu Lys Glu Gln Val Pro 
            20                  25                  30          


Gly Phe Thr Pro Arg Leu Ala Ile Leu Gln Val Gly Asn Arg Asp Asp 
        35                  40                  45              


Ser Asn Leu Tyr Ile Asn Val Lys Leu Lys Ala Ala Glu Glu Ile Gly 
    50                  55                  60                  


Ile Lys Ala Thr His Ile Lys Leu Pro Arg Thr Thr Thr Glu Ser Glu 
65                  70                  75                  80  


Val Met Lys Tyr Ile Thr Ser Leu Asn Glu Asp Ser Thr Val His Gly 
                85                  90                  95      


Phe Leu Val Gln Leu Pro Leu Asp Ser Glu Asn Ser Ile Asn Thr Glu 
            100                 105                 110         


Glu Val Ile Asn Ala Ile Ala Pro Glu Lys Asp Val Asp Gly Leu Thr 
        115                 120                 125             


Ser Ile Asn Ala Gly Lys Leu Ala Arg Gly Asp Leu Asn Asp Cys Phe 
    130                 135                 140                 


Ile Pro Cys Thr Pro Lys Gly Cys Leu Glu Leu Ile Lys Glu Thr Gly 
145                 150                 155                 160 


Val Pro Ile Ala Gly Arg His Ala Val Val Val Gly Arg Ser Lys Ile 
                165                 170                 175     


Val Gly Ala Pro Met His Asp Leu Leu Leu Trp Asn Asn Ala Thr Val 
            180                 185                 190         


Thr Thr Cys His Ser Lys Thr Ala His Leu Asp Glu Glu Val Asn Lys 
        195                 200                 205             


Gly Asp Ile Leu Val Val Ala Thr Gly Gln Pro Glu Met Val Lys Gly 
    210                 215                 220                 


Glu Trp Ile Lys Pro Gly Ala Ile Val Ile Asp Cys Gly Ile Asn Tyr 
225                 230                 235                 240 


Val Pro Asp Asp Lys Lys Pro Asn Gly Arg Lys Val Val Gly Asp Val 
                245                 250                 255     


Ala Tyr Asp Glu Ala Lys Glu Arg Ala Ser Phe Ile Thr Pro Val Pro 
            260                 265                 270         


Gly Gly Val Gly Pro Met Thr Val Ala Met Leu Met Gln Ser Thr Val 
        275                 280                 285             


Glu Ser Ala Lys Arg Phe Leu Glu Lys Phe Lys Pro Gly Lys Trp Met 
    290                 295                 300                 


Ile Gln Tyr Asn Asn Leu Asn Leu Lys Thr Pro Val Pro Ser Asp Ile 
305                 310                 315                 320 


Asp Ile Ser Arg Ser Cys Lys Pro Lys Pro Ile Gly Lys Leu Ala Arg 
                325                 330                 335     


Glu Ile Gly Leu Leu Ser Glu Glu Val Glu Leu Tyr Gly Glu Thr Lys 
            340                 345                 350         


Ala Lys Val Leu Leu Ser Ala Leu Glu Arg Leu Lys His Arg Pro Asp 
        355                 360                 365             


Gly Lys Tyr Val Val Val Thr Gly Ile Thr Pro Thr Pro Leu Gly Glu 
    370                 375                 380                 


Gly Lys Ser Thr Thr Thr Ile Gly Leu Val Gln Ala Leu Gly Ala His 
385                 390                 395                 400 


Leu Tyr Gln Asn Val Phe Ala Cys Val Arg Gln Pro Ser Gln Gly Pro 
                405                 410                 415     


Thr Phe Gly Ile Lys Gly Gly Ala Ala Gly Gly Gly Tyr Ser Gln Val 
            420                 425                 430         


Ile Pro Met Glu Glu Phe Asn Leu His Leu Thr Gly Asp Ile His Ala 
        435                 440                 445             


Ile Thr Ala Ala Asn Asn Leu Val Ala Ala Ala Ile Asp Ala Arg Ile 
    450                 455                 460                 


Phe His Glu Leu Thr Gln Thr Asp Lys Ala Leu Phe Asn Arg Leu Val 
465                 470                 475                 480 


Pro Ser Val Asn Gly Val Arg Arg Phe Ser Asp Ile Gln Ile Arg Arg 
                485                 490                 495     


Leu Lys Arg Leu Gly Ile Glu Lys Thr Asp Pro Thr Thr Leu Thr Asp 
            500                 505                 510         


Glu Glu Ile Asn Arg Phe Ala Arg Leu Asp Ile Asp Pro Glu Thr Ile 
        515                 520                 525             


Thr Trp Gln Arg Val Leu Asp Thr Asn Asp Arg Phe Leu Arg Lys Ile 
    530                 535                 540                 


Thr Ile Gly Gln Ala Pro Thr Glu Lys Gly His Thr Arg Thr Ala Gln 
545                 550                 555                 560 


Phe Asp Ile Ser Val Ala Ser Glu Ile Met Ala Val Leu Ala Leu Thr 
                565                 570                 575     


Thr Ser Leu Glu Asp Met Arg Glu Arg Leu Gly Lys Met Val Val Ala 
            580                 585                 590         


Ser Ser Lys Lys Gly Glu Pro Val Ser Ala Glu Asp Leu Gly Val Ser 
        595                 600                 605             


Gly Ala Leu Thr Val Leu Met Lys Asp Ala Ile Lys Pro Asn Leu Met 
    610                 615                 620                 


Gln Thr Leu Glu Gly Thr Pro Val Phe Val His Ala Gly Pro Phe Ala 
625                 630                 635                 640 


Asn Ile Ala His Gly Asn Ser Ser Ile Ile Ala Asp Arg Ile Ala Leu 
                645                 650                 655     


Lys Leu Val Gly Pro Glu Gly Phe Val Val Thr Glu Ala Gly Phe Gly 
            660                 665                 670         


Ala Asp Ile Gly Met Glu Lys Phe Phe Asn Ile Lys Cys Arg Tyr Ser 
        675                 680                 685             


Gly Leu Cys Pro His Val Val Val Leu Val Ala Thr Val Arg Ala Leu 
    690                 695                 700                 


Lys Met His Gly Gly Gly Pro Thr Val Thr Ala Gly Leu Pro Leu Pro 
705                 710                 715                 720 


Lys Ala Tyr Ile Gln Glu Asn Leu Glu Leu Val Glu Lys Gly Phe Ser 
                725                 730                 735     


Asn Leu Lys Lys Gln Ile Glu Asn Ala Arg Met Phe Gly Ile Pro Val 
            740                 745                 750         


Val Val Ala Val Asn Ala Phe Lys Thr Asp Thr Glu Ser Glu Leu Asp 
        755                 760                 765             


Leu Ile Ser Arg Leu Ser Arg Glu His Gly Ala Phe Asp Ala Val Lys 
    770                 775                 780                 


Cys Thr His Trp Ala Glu Gly Gly Lys Gly Ala Leu Ala Leu Ala Gln 
785                 790                 795                 800 


Ala Val Gln Arg Ala Ala Gln Ala Pro Ser Ser Phe Gln Leu Leu Tyr 
                805                 810                 815     


Asp Leu Lys Leu Pro Val Glu Asp Lys Ile Arg Ile Ile Ala Gln Lys 
            820                 825                 830         


Ile Tyr Gly Ala Asp Asp Ile Glu Leu Leu Pro Glu Ala Gln His Lys 
        835                 840                 845             


Ala Glu Val Tyr Thr Lys Gln Gly Phe Gly Asn Leu Pro Ile Cys Met 
    850                 855                 860                 


Ala Lys Thr His Leu Ser Leu Ser His Asn Pro Glu Gln Lys Gly Val 
865                 870                 875                 880 


Pro Thr Gly Phe Ile Leu Pro Ile Arg Asp Ile Arg Ala Ser Val Gly 
                885                 890                 895     


Ala Gly Phe Leu Tyr Pro Leu Val Gly Thr Met Ser Thr Met Pro Gly 
            900                 905                 910         


Leu Pro Thr Arg Pro Cys Phe Tyr Asp Ile Asp Leu Asp Pro Glu Thr 
        915                 920                 925             


Glu Gln Val Asn Gly Leu Phe 
    930                 935 


<210>  3406
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  3406

Met Gln Gly Asn Gly Ser Ala Leu Pro Asn Ala Ser Gln Pro Val Leu 
1               5                   10                  15      


Arg Gly Asp Gly Ala Arg Pro Ser Trp Leu Ala Ser Ala Leu Ala Cys 
            20                  25                  30          


Val Leu Ile Phe Thr Ile Val Val Asp Ile Leu Gly Asn Leu Leu Val 
        35                  40                  45              


Ile Leu Ser Val Tyr Arg Asn Lys Lys Leu Arg Asn Ala Gly Asn Ile 
    50                  55                  60                  


Phe Val Val Ser Leu Ala Val Ala Asp Leu Val Val Ala Ile Tyr Pro 
65                  70                  75                  80  


Tyr Pro Leu Val Leu Met Ser Ile Phe Asn Asn Gly Trp Asn Leu Gly 
                85                  90                  95      


Tyr Leu His Cys Gln Val Ser Gly Phe Leu Met Gly Leu Ser Val Ile 
            100                 105                 110         


Gly Ser Ile Phe Asn Ile Thr Gly Ile Ala Ile Asn Arg Tyr Cys Tyr 
        115                 120                 125             


Ile Cys His Ser Leu Lys Tyr Asp Lys Leu Tyr Ser Ser Lys Asn Ser 
    130                 135                 140                 


Leu Cys Tyr Val Leu Leu Ile Trp Leu Leu Thr Leu Ala Ala Val Leu 
145                 150                 155                 160 


Pro Asn Leu Arg Ala Gly Thr Leu Gln Tyr Asp Pro Arg Ile Tyr Ser 
                165                 170                 175     


Cys Thr Phe Ala Gln Ser Val Ser Ser Ala Tyr Thr Ile Ala Val Val 
            180                 185                 190         


Val Phe His Phe Leu Val Pro Met Ile Ile Val Ile Phe Cys Tyr Leu 
        195                 200                 205             


Arg Ile Trp Ile Leu Val Leu Gln Val Arg Gln Arg Val Lys Pro Asp 
    210                 215                 220                 


Arg Lys Pro Lys Leu Lys Pro Gln Asp Phe Arg Asn Phe Val Thr Met 
225                 230                 235                 240 


Phe Val Val Phe Val Leu Phe Ala Ile Cys Trp Ala Pro Leu Asn Phe 
                245                 250                 255     


Ile Gly Leu Ala Val Ala Ser Asp Pro Ala Ser Met Val Pro Arg Ile 
            260                 265                 270         


Pro Glu Trp Leu Phe Val Ala Ser Tyr Tyr Met Ala Tyr Phe Asn Ser 
        275                 280                 285             


Cys Leu Asn Ala Ile Ile Tyr Gly Leu Leu Asn Gln Asn Phe Arg Lys 
    290                 295                 300                 


Glu Tyr Arg Arg Ile Ile Val Ser Leu Cys Thr Ala Arg Val Phe Phe 
305                 310                 315                 320 


Val Asp Ser Ser Asn Asp Val Ala Asp Arg Val Lys Trp Lys Pro Ser 
                325                 330                 335     


Pro Leu Met Thr Asn Asn Asn Val Val Lys Val Asp Ser Val 
            340                 345                 350 


<210>  3407
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  3407

Met Ser Glu Asn Gly Ser Phe Ala Asn Cys Cys Glu Ala Gly Gly Trp 
1               5                   10                  15      


Ala Val Arg Pro Gly Trp Ser Gly Ala Gly Ser Ala Arg Pro Ser Arg 
            20                  25                  30          


Thr Pro Arg Pro Pro Trp Val Ala Pro Ala Leu Ser Ala Val Leu Ile 
        35                  40                  45              


Val Thr Thr Ala Val Asp Val Val Gly Asn Leu Leu Val Ile Leu Ser 
    50                  55                  60                  


Val Leu Arg Asn Arg Lys Leu Arg Asn Ala Gly Asn Leu Phe Leu Val 
65                  70                  75                  80  


Ser Leu Ala Leu Ala Asp Leu Val Val Ala Phe Tyr Pro Tyr Pro Leu 
                85                  90                  95      


Ile Leu Val Ala Ile Phe Tyr Asp Gly Trp Ala Leu Gly Glu Glu His 
            100                 105                 110         


Cys Lys Ala Ser Ala Phe Val Met Gly Leu Ser Val Ile Gly Ser Val 
        115                 120                 125             


Phe Asn Ile Thr Ala Ile Ala Ile Asn Arg Tyr Cys Tyr Ile Cys His 
    130                 135                 140                 


Ser Met Ala Tyr His Arg Ile Tyr Arg Arg Trp His Thr Pro Leu His 
145                 150                 155                 160 


Ile Cys Leu Ile Trp Leu Leu Thr Val Val Ala Leu Leu Pro Asn Phe 
                165                 170                 175     


Phe Val Gly Ser Leu Glu Tyr Asp Pro Arg Ile Tyr Ser Cys Thr Phe 
            180                 185                 190         


Ile Gln Thr Ala Ser Thr Gln Tyr Thr Ala Ala Val Val Val Ile His 
        195                 200                 205             


Phe Leu Leu Pro Ile Ala Val Val Ser Phe Cys Tyr Leu Arg Ile Trp 
    210                 215                 220                 


Val Leu Val Leu Gln Ala Arg Arg Lys Ala Lys Pro Glu Ser Arg Leu 
225                 230                 235                 240 


Cys Leu Lys Pro Ser Asp Leu Arg Ser Phe Leu Thr Met Phe Val Val 
                245                 250                 255     


Phe Val Ile Phe Ala Ile Cys Trp Ala Pro Leu Asn Cys Ile Gly Leu 
            260                 265                 270         


Ala Val Ala Ile Asn Pro Gln Glu Met Ala Pro Gln Ile Pro Glu Gly 
        275                 280                 285             


Leu Phe Val Thr Ser Tyr Leu Leu Ala Tyr Phe Asn Ser Cys Leu Asn 
    290                 295                 300                 


Ala Ile Val Tyr Gly Leu Leu Asn Gln Asn Phe Arg Arg Glu Tyr Lys 
305                 310                 315                 320 


Arg Ile Leu Leu Ala Leu Trp Asn Pro Arg His Cys Ile Gln Asp Ala 
                325                 330                 335     


Ser Lys Gly Ser His Ala Glu Gly Leu Gln Ser Pro Ala Pro Pro Ile 
            340                 345                 350         


Ile Gly Val Gln His Gln Ala Asp Ala Leu 
        355                 360         


<210>  3408
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  3408

Met Gln Lys Val Thr Leu Gly Leu Leu Val Phe Leu Ala Gly Phe Pro 
1               5                   10                  15      


Val Leu Asp Ala Asn Asp Leu Glu Asp Lys Asn Ser Pro Phe Tyr Tyr 
            20                  25                  30          


Asp Trp His Ser Leu Gln Val Gly Gly Leu Ile Cys Ala Gly Val Leu 
        35                  40                  45              


Cys Ala Met Gly Ile Ile Ile Val Met Ser Ala Lys Cys Lys Cys Lys 
    50                  55                  60                  


Phe Gly Gln Lys Ser Gly His His Pro Gly Glu Thr Pro Pro Leu Ile 
65                  70                  75                  80  


Thr Pro Gly Ser Ala Gln Ser 
                85          


<210>  3409
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  3409

Met Asn Thr Ser His Leu Leu Ala Leu Leu Leu Pro Lys Ser Pro Gln 
1               5                   10                  15      


Gly Glu Asn Arg Ser Lys Pro Leu Gly Thr Pro Tyr Asn Phe Ser Glu 
            20                  25                  30          


His Cys Gln Asp Ser Val Asp Val Met Val Phe Ile Val Thr Ser Tyr 
        35                  40                  45              


Ser Ile Glu Thr Val Val Gly Val Leu Gly Asn Leu Cys Leu Met Cys 
    50                  55                  60                  


Val Thr Val Arg Gln Lys Glu Lys Ala Asn Val Thr Asn Leu Leu Ile 
65                  70                  75                  80  


Ala Asn Leu Ala Phe Ser Asp Phe Leu Met Cys Leu Leu Cys Gln Pro 
                85                  90                  95      


Leu Thr Ala Val Tyr Thr Ile Met Asp Tyr Trp Ile Phe Gly Glu Thr 
            100                 105                 110         


Leu Cys Lys Met Ser Ala Phe Ile Gln Cys Met Ser Val Thr Val Ser 
        115                 120                 125             


Ile Leu Ser Leu Val Leu Val Ala Leu Glu Arg His Gln Leu Ile Ile 
    130                 135                 140                 


Asn Pro Thr Gly Trp Lys Pro Ser Ile Ser Gln Ala Tyr Leu Gly Ile 
145                 150                 155                 160 


Val Leu Ile Trp Val Ile Ala Cys Val Leu Ser Leu Pro Phe Leu Ala 
                165                 170                 175     


Asn Ser Ile Leu Glu Asn Val Phe His Lys Asn His Ser Lys Ala Leu 
            180                 185                 190         


Glu Phe Leu Ala Asp Lys Val Val Cys Thr Glu Ser Trp Pro Leu Ala 
        195                 200                 205             


His His Arg Thr Ile Tyr Thr Thr Phe Leu Leu Leu Phe Gln Tyr Cys 
    210                 215                 220                 


Leu Pro Leu Gly Phe Ile Leu Val Cys Tyr Ala Arg Ile Tyr Arg Cys 
225                 230                 235                 240 


Leu Gln Arg Gln Gly Arg Val Phe His Lys Gly Thr Tyr Ser Leu Arg 
                245                 250                 255     


Ala Gly His Met Lys Gln Val Asn Val Val Leu Val Val Met Val Val 
            260                 265                 270         


Ala Phe Ala Val Leu Trp Leu Pro Leu His Val Phe Asn Ser Leu Glu 
        275                 280                 285             


Asp Trp His His Glu Ala Ile Pro Ile Cys His Gly Asn Leu Ile Phe 
    290                 295                 300                 


Leu Val Cys His Leu Leu Ala Met Ala Ser Thr Cys Val Asn Pro Phe 
305                 310                 315                 320 


Ile Tyr Gly Phe Leu Asn Thr Asn Phe Lys Lys Glu Ile Lys Ala Leu 
                325                 330                 335     


Val Leu Thr Cys Gln Gln Ser Ala Pro Leu Glu Glu Ser Glu His Leu 
            340                 345                 350         


Pro Leu Ser Thr Val His Thr Glu Val Ser Lys Gly Ser Leu Arg Leu 
        355                 360                 365             


Ser Gly Arg Ser Asn Pro Ile 
    370                 375 


<210>  3410
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  3410

Met Val Cys Gly Gly Phe Ala Cys Ser Lys Asn Ala Leu Cys Ala Leu 
1               5                   10                  15      


Asn Val Val Tyr Met Leu Val Ser Leu Leu Leu Ile Gly Val Ala Ala 
            20                  25                  30          


Trp Gly Lys Gly Leu Gly Leu Val Ser Ser Ile His Ile Ile Gly Gly 
        35                  40                  45              


Val Ile Ala Val Gly Val Phe Leu Leu Leu Ile Ala Val Ala Gly Leu 
    50                  55                  60                  


Val Gly Ala Val Asn His His Gln Val Leu Leu Phe Phe Tyr Met Ile 
65                  70                  75                  80  


Ile Leu Gly Leu Val Phe Ile Phe Gln Phe Val Ile Ser Cys Ser Cys 
                85                  90                  95      


Leu Ala Ile Asn Arg Ser Lys Gln Thr Asp Val Ile Asn Ala Ser Trp 
            100                 105                 110         


Trp Val Met Ser Asn Lys Thr Arg Asp Glu Leu Glu Arg Ser Phe Asp 
        115                 120                 125             


Cys Cys Gly Leu Phe Asn Leu Thr Thr Leu Tyr Gln Gln Asp Tyr Asp 
    130                 135                 140                 


Phe Cys Thr Ala Ile Cys Lys Ser Gln Ser Pro Thr Cys Gln Met Cys 
145                 150                 155                 160 


Gly Glu Lys Phe Leu Lys His Ser Asp Glu Ala Leu Lys Ile Leu Gly 
                165                 170                 175     


Gly Val Gly Leu Phe Phe Ser Phe Thr Glu Ile Leu Gly Val Trp Leu 
            180                 185                 190         


Ala Met Arg Phe Arg Asn Gln Lys Asp Pro Arg Ala Asn Pro Ser Ala 
        195                 200                 205             


Phe Leu 
    210 


<210>  3411
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  3411

Met Tyr Ser Met Met Met Glu Thr Asp Leu His Ser Pro Gly Gly Ala 
1               5                   10                  15      


Gln Ala Pro Thr Asn Leu Ser Gly Pro Ala Gly Ala Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Lys Ala Asn Gln 
        35                  40                  45              


Asp Arg Val Lys Arg Pro Met Asn Ala Phe Met Val Trp Ser Arg Gly 
    50                  55                  60                  


Gln Arg Arg Lys Met Ala Gln Glu Asn Pro Lys Met His Asn Ser Glu 
65                  70                  75                  80  


Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys Val Met Ser Glu Ala Glu 
                85                  90                  95      


Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg Leu Arg Ala Leu His Met 
            100                 105                 110         


Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro Arg Arg Lys Thr Lys Thr 
        115                 120                 125             


Leu Leu Lys Lys Asp Lys Tyr Ser Leu Ala Gly Gly Leu Leu Ala Ala 
    130                 135                 140                 


Gly Ala Gly Gly Gly Gly Ala Ala Val Ala Met Gly Val Gly Val Gly 
145                 150                 155                 160 


Val Gly Ala Ala Ala Val Gly Gln Arg Leu Glu Ser Pro Gly Gly Ala 
                165                 170                 175     


Ala Gly Gly Gly Tyr Ala His Val Asn Gly Trp Ala Asn Gly Ala Tyr 
            180                 185                 190         


Pro Gly Ser Val Ala Ala Ala Ala Ala Ala Ala Ala Met Met Gln Glu 
        195                 200                 205             


Ala Gln Leu Ala Tyr Gly Gln His Pro Gly Ala Gly Gly Ala His Pro 
    210                 215                 220                 


His Ala His Pro Ala His Pro His Pro His His Pro His Ala His Pro 
225                 230                 235                 240 


His Asn Pro Gln Pro Met His Arg Tyr Asp Met Gly Ala Leu Gln Tyr 
                245                 250                 255     


Ser Pro Ile Ser Asn Ser Gln Gly Tyr Met Ser Ala Ser Pro Ser Gly 
            260                 265                 270         


Tyr Gly Gly Leu Pro Tyr Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        275                 280                 285             


Gly Gly Ala His Gln Asn Ser Ala Val Ala Ala Ala Ala Ala Ala Ala 
    290                 295                 300                 


Ala Ala Ser Ser Gly Ala Leu Gly Ala Leu Gly Ser Leu Val Lys Ser 
305                 310                 315                 320 


Glu Pro Ser Gly Ser Pro Pro Ala Pro Ala His Ser Arg Ala Pro Cys 
                325                 330                 335     


Pro Gly Asp Leu Arg Glu Met Ile Ser Met Tyr Leu Pro Ala Gly Glu 
            340                 345                 350         


Gly Gly Asp Pro Ala Ala Ala Ala Ala Ala Ala Ala Gln Ser Arg Leu 
        355                 360                 365             


His Ser Leu Pro Gln His Tyr Gln Gly Ala Gly Ala Gly Val Asn Gly 
    370                 375                 380                 


Thr Val Pro Leu Thr His Ile 
385                 390     


<210>  3412
<211>  890
<212>  PRT
<213>  Homo sapiens

<400>  3412

Met Asp Ser Asn Thr Ala Pro Leu Gly Pro Ser Cys Pro Gln Pro Pro 
1               5                   10                  15      


Pro Ala Pro Gln Pro Gln Ala Arg Ser Arg Leu Asn Ala Thr Ala Ser 
            20                  25                  30          


Leu Glu Gln Glu Arg Ser Glu Arg Pro Arg Ala Pro Gly Pro Gln Ala 
        35                  40                  45              


Gly Pro Gly Pro Gly Val Arg Asp Ala Ala Ala Pro Ala Glu Pro Gln 
    50                  55                  60                  


Ala Gln His Thr Arg Ser Arg Glu Arg Ala Asp Gly Thr Gly Pro Thr 
65                  70                  75                  80  


Lys Gly Asp Met Glu Ile Pro Phe Glu Glu Val Leu Glu Arg Ala Lys 
                85                  90                  95      


Ala Gly Asp Pro Lys Ala Gln Thr Glu Val Gly Lys His Tyr Leu Gln 
            100                 105                 110         


Leu Ala Gly Asp Thr Asp Glu Glu Leu Asn Ser Cys Thr Ala Val Asp 
        115                 120                 125             


Trp Leu Val Leu Ala Ala Lys Gln Gly Arg Arg Glu Ala Val Lys Leu 
    130                 135                 140                 


Leu Arg Arg Cys Leu Ala Asp Arg Arg Gly Ile Thr Ser Glu Asn Glu 
145                 150                 155                 160 


Arg Glu Val Arg Gln Leu Ser Ser Glu Thr Asp Leu Glu Arg Ala Val 
                165                 170                 175     


Arg Lys Ala Ala Leu Val Met Tyr Trp Lys Leu Asn Pro Lys Lys Lys 
            180                 185                 190         


Lys Gln Val Ala Val Ala Glu Leu Leu Glu Asn Val Gly Gln Val Asn 
        195                 200                 205             


Glu His Asp Gly Gly Ala Gln Pro Gly Pro Val Pro Lys Ser Leu Gln 
    210                 215                 220                 


Lys Gln Arg Arg Met Leu Glu Arg Leu Val Ser Ser Glu Ser Lys Asn 
225                 230                 235                 240 


Tyr Ile Ala Leu Asp Asp Phe Val Glu Ile Thr Lys Lys Tyr Ala Lys 
                245                 250                 255     


Gly Val Ile Pro Ser Ser Leu Phe Leu Gln Asp Asp Glu Asp Asp Asp 
            260                 265                 270         


Glu Leu Ala Gly Lys Ser Pro Glu Asp Leu Pro Leu Arg Leu Lys Val 
        275                 280                 285             


Val Lys Tyr Pro Leu His Ala Ile Met Glu Ile Lys Glu Tyr Leu Ile 
    290                 295                 300                 


Asp Met Ala Ser Arg Ala Gly Met His Trp Leu Ser Thr Ile Ile Pro 
305                 310                 315                 320 


Thr His His Ile Asn Ala Leu Ile Phe Phe Phe Ile Val Ser Asn Leu 
                325                 330                 335     


Thr Ile Asp Phe Phe Ala Phe Phe Ile Pro Leu Val Ile Phe Tyr Leu 
            340                 345                 350         


Ser Phe Ile Ser Met Val Ile Cys Thr Leu Lys Val Phe Gln Asp Ser 
        355                 360                 365             


Lys Ala Trp Glu Asn Phe Arg Thr Leu Thr Asp Leu Leu Leu Arg Phe 
    370                 375                 380                 


Glu Pro Asn Leu Asp Val Glu Gln Ala Glu Val Asn Phe Gly Trp Asn 
385                 390                 395                 400 


His Leu Glu Pro Tyr Ala His Phe Leu Leu Ser Val Phe Phe Val Ile 
                405                 410                 415     


Phe Ser Phe Pro Ile Ala Ser Lys Asp Cys Ile Pro Cys Ser Glu Leu 
            420                 425                 430         


Ala Val Ile Thr Gly Phe Phe Thr Val Thr Ser Tyr Leu Ser Leu Ser 
        435                 440                 445             


Thr His Ala Glu Pro Tyr Thr Arg Arg Ala Leu Ala Thr Glu Val Thr 
    450                 455                 460                 


Ala Gly Leu Leu Ser Leu Leu Pro Ser Met Pro Leu Asn Trp Pro Tyr 
465                 470                 475                 480 


Leu Lys Val Leu Gly Gln Thr Phe Ile Thr Val Pro Val Gly His Leu 
                485                 490                 495     


Val Val Leu Asn Val Ser Val Pro Cys Leu Leu Tyr Val Tyr Leu Leu 
            500                 505                 510         


Tyr Leu Phe Phe Arg Met Ala Gln Leu Arg Asn Phe Lys Gly Thr Tyr 
        515                 520                 525             


Cys Tyr Leu Val Pro Tyr Leu Val Cys Phe Met Trp Cys Glu Leu Ser 
    530                 535                 540                 


Val Val Ile Leu Leu Glu Ser Thr Gly Leu Gly Leu Leu Arg Ala Ser 
545                 550                 555                 560 


Ile Gly Tyr Phe Leu Phe Leu Phe Ala Leu Pro Ile Leu Val Ala Gly 
                565                 570                 575     


Leu Ala Leu Val Gly Val Leu Gln Phe Ala Arg Trp Phe Thr Ser Leu 
            580                 585                 590         


Glu Leu Thr Lys Ile Ala Val Thr Val Ala Val Cys Ser Val Pro Leu 
        595                 600                 605             


Leu Leu Arg Trp Trp Thr Lys Ala Ser Phe Ser Val Val Gly Met Val 
    610                 615                 620                 


Lys Ser Leu Thr Arg Ser Ser Met Val Lys Leu Ile Leu Val Trp Leu 
625                 630                 635                 640 


Thr Ala Ile Val Leu Phe Cys Trp Phe Tyr Val Tyr Arg Ser Glu Gly 
                645                 650                 655     


Met Lys Val Tyr Asn Ser Thr Leu Thr Trp Gln Gln Tyr Gly Ala Leu 
            660                 665                 670         


Cys Gly Pro Arg Ala Trp Lys Glu Thr Asn Met Ala Arg Thr Gln Ile 
        675                 680                 685             


Leu Cys Ser His Leu Glu Gly His Arg Val Thr Trp Thr Gly Arg Phe 
    690                 695                 700                 


Lys Tyr Val Arg Val Thr Asp Ile Asp Asn Ser Ala Glu Ser Ala Ile 
705                 710                 715                 720 


Asn Met Leu Pro Phe Phe Ile Gly Asp Trp Met Arg Cys Leu Tyr Gly 
                725                 730                 735     


Glu Ala Tyr Pro Ala Cys Ser Pro Gly Asn Thr Ser Thr Ala Glu Glu 
            740                 745                 750         


Glu Leu Cys Arg Leu Lys Leu Leu Ala Lys His Pro Cys His Ile Lys 
        755                 760                 765             


Lys Phe Asp Arg Tyr Lys Phe Glu Ile Thr Val Gly Met Pro Phe Ser 
    770                 775                 780                 


Ser Gly Ala Asp Gly Ser Arg Ser Arg Glu Glu Asp Asp Val Thr Lys 
785                 790                 795                 800 


Asp Ile Val Leu Arg Ala Ser Ser Glu Phe Lys Ser Val Leu Leu Ser 
                805                 810                 815     


Leu Arg Gln Gly Ser Leu Ile Glu Phe Ser Thr Ile Leu Glu Gly Arg 
            820                 825                 830         


Leu Gly Ser Lys Trp Pro Val Phe Glu Leu Lys Ala Ile Ser Cys Leu 
        835                 840                 845             


Asn Cys Met Ala Gln Leu Ser Pro Thr Arg Arg His Val Lys Ile Glu 
    850                 855                 860                 


His Asp Trp Arg Ser Thr Val His Gly Ala Val Lys Phe Ala Phe Asp 
865                 870                 875                 880 


Phe Phe Phe Phe Pro Phe Leu Ser Ala Ala 
                885                 890 


<210>  3413
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  3413

Met Gln Leu Gln Phe Arg Ser Trp Met Leu Ala Ala Leu Thr Leu Leu 
1               5                   10                  15      


Val Val Phe Leu Ile Phe Ala Asp Ile Ser Glu Ile Glu Glu Glu Ile 
            20                  25                  30          


Gly Asn Ser Gly Gly Arg Gly Thr Ile Arg Ser Ala Val Asn Ser Leu 
        35                  40                  45              


His Ser Lys Ser Asn Arg Ala Glu Val Val Ile Asn Gly Ser Ser Ser 
    50                  55                  60                  


Pro Ala Val Val Asp Arg Ser Asn Glu Ser Ile Lys His Asn Ile Gln 
65                  70                  75                  80  


Pro Ala Ser Ser Lys Trp Arg His Asn Gln Thr Leu Ser Leu Arg Ile 
                85                  90                  95      


Arg Lys Gln Ile Leu Lys Phe Leu Asp Ala Glu Lys Asp Ile Ser Val 
            100                 105                 110         


Leu Lys Gly Thr Leu Lys Pro Gly Asp Ile Ile His Tyr Ile Phe Asp 
        115                 120                 125             


Arg Asp Ser Thr Met Asn Val Ser Gln Asn Leu Tyr Glu Leu Leu Pro 
    130                 135                 140                 


Arg Thr Ser Pro Leu Lys Asn Lys His Phe Gly Thr Cys Ala Ile Val 
145                 150                 155                 160 


Gly Asn Ser Gly Val Leu Leu Asn Ser Gly Cys Gly Gln Glu Ile Asp 
                165                 170                 175     


Ala His Ser Phe Val Ile Arg Cys Asn Leu Ala Pro Val Gln Glu Tyr 
            180                 185                 190         


Ala Arg Asp Val Gly Leu Lys Thr Asp Leu Val Thr Met Asn Pro Ser 
        195                 200                 205             


Val Ile Gln Arg Ala Phe Glu Asp Leu Val Asn Ala Thr Trp Arg Glu 
    210                 215                 220                 


Lys Leu Leu Gln Arg Leu His Ser Leu Asn Gly Ser Ile Leu Trp Ile 
225                 230                 235                 240 


Pro Ala Phe Met Ala Arg Gly Gly Lys Glu Arg Val Glu Trp Val Asn 
                245                 250                 255     


Glu Leu Ile Leu Lys His His Val Asn Val Arg Thr Ala Tyr Pro Ser 
            260                 265                 270         


Leu Arg Leu Leu His Ala Val Arg Gly Tyr Trp Leu Thr Asn Lys Val 
        275                 280                 285             


His Ile Lys Arg Pro Thr Thr Gly Leu Leu Met Tyr Thr Leu Ala Thr 
    290                 295                 300                 


Arg Phe Cys Lys Gln Ile Tyr Leu Tyr Gly Phe Trp Pro Phe Pro Leu 
305                 310                 315                 320 


Asp Gln Asn Gln Asn Pro Val Lys Tyr His Tyr Tyr Asp Ser Leu Lys 
                325                 330                 335     


Tyr Gly Tyr Thr Ser Gln Ala Ser Pro His Thr Met Pro Leu Glu Phe 
            340                 345                 350         


Lys Ala Leu Lys Ser Leu His Glu Gln Gly Ala Leu Lys Leu Thr Val 
        355                 360                 365             


Gly Gln Cys Asp Gly Ala Thr 
    370                 375 


<210>  3414
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  3414

Met Ser Arg Leu Ser Arg Ser Leu Leu Trp Ala Ala Thr Cys Leu Gly 
1               5                   10                  15      


Val Leu Cys Val Leu Ser Ala Asp Lys Asn Thr Thr Gln His Pro Asn 
            20                  25                  30          


Val Thr Thr Leu Ala Pro Ile Ser Asn Val Thr Ser Ala Pro Val Thr 
        35                  40                  45              


Ser Leu Pro Leu Val Thr Thr Pro Ala Pro Glu Thr Cys Glu Gly Arg 
    50                  55                  60                  


Asn Ser Cys Val Ser Cys Phe Asn Val Ser Val Val Asn Thr Thr Cys 
65                  70                  75                  80  


Phe Trp Ile Glu Cys Lys Asp Glu Ser Tyr Cys Ser His Asn Ser Thr 
                85                  90                  95      


Val Ser Asp Cys Gln Val Gly Asn Thr Thr Asp Phe Cys Ser Val Ser 
            100                 105                 110         


Thr Ala Thr Pro Val Pro Thr Ala Asn Ser Thr Ala Lys Pro Thr Val 
        115                 120                 125             


Gln Pro Ser Pro Ser Thr Thr Ser Lys Thr Val Thr Thr Ser Gly Thr 
    130                 135                 140                 


Thr Asn Asn Thr Val Thr Pro Thr Ser Gln Pro Val Arg Lys Ser Thr 
145                 150                 155                 160 


Phe Asp Ala Ala Ser Phe Ile Gly Gly Ile Val Leu Val Leu Gly Val 
                165                 170                 175     


Gln Ala Val Ile Phe Phe Leu Tyr Lys Phe Cys Lys Ser Lys Glu Arg 
            180                 185                 190         


Asn Tyr His Thr Leu 
        195         


<210>  3415
<211>  865
<212>  PRT
<213>  Homo sapiens

<400>  3415

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15      


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30          


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45              


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60                  


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80  


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Pro Glu Thr Val 
                85                  90                  95      


Ile Leu Gly Leu Lys Ile Val Tyr Tyr Glu Ala Gly Ile Ile Leu Cys 
            100                 105                 110         


Cys Val Leu Gly Leu Leu Phe Ile Ile Leu Met Pro Leu Val Gly Tyr 
        115                 120                 125             


Phe Phe Cys Met Cys Arg Cys Cys Asn Lys Cys Gly Gly Glu Met His 
    130                 135                 140                 


Gln Arg Gln Lys Glu Asn Gly Pro Phe Leu Arg Lys Cys Phe Ala Ile 
145                 150                 155                 160 


Ser Leu Leu Val Ile Cys Ile Ile Ile Ser Ile Gly Ile Phe Tyr Gly 
                165                 170                 175     


Phe Val Ala Asn His Gln Val Arg Thr Arg Ile Lys Arg Ser Arg Lys 
            180                 185                 190         


Leu Ala Asp Ser Asn Phe Lys Asp Leu Arg Thr Leu Leu Asn Glu Thr 
        195                 200                 205             


Pro Glu Gln Ile Lys Tyr Ile Leu Ala Gln Tyr Asn Thr Thr Lys Asp 
    210                 215                 220                 


Lys Ala Phe Thr Asp Leu Asn Ser Ile Asn Ser Val Leu Gly Gly Gly 
225                 230                 235                 240 


Ile Leu Asp Arg Leu Arg Pro Asn Ile Ile Pro Val Leu Asp Glu Ile 
                245                 250                 255     


Lys Ser Met Ala Thr Ala Ile Lys Glu Thr Lys Glu Ala Leu Glu Asn 
            260                 265                 270         


Met Asn Ser Thr Leu Lys Ser Leu His Gln Gln Ser Thr Gln Leu Ser 
        275                 280                 285             


Ser Ser Leu Thr Ser Val Lys Thr Ser Leu Arg Ser Ser Leu Asn Asp 
    290                 295                 300                 


Pro Leu Cys Leu Val His Pro Ser Ser Glu Thr Cys Asn Ser Ile Arg 
305                 310                 315                 320 


Leu Ser Leu Ser Gln Leu Asn Ser Asn Pro Glu Leu Arg Gln Leu Pro 
                325                 330                 335     


Pro Val Asp Ala Glu Leu Asp Asn Val Asn Asn Val Leu Arg Thr Asp 
            340                 345                 350         


Leu Asp Gly Leu Val Gln Gln Gly Tyr Gln Ser Leu Asn Asp Ile Pro 
        355                 360                 365             


Asp Arg Val Gln Arg Gln Thr Thr Thr Val Val Ala Gly Ile Lys Arg 
    370                 375                 380                 


Val Leu Asn Ser Ile Gly Ser Asp Ile Asp Asn Val Thr Gln Arg Leu 
385                 390                 395                 400 


Pro Ile Gln Asp Ile Leu Ser Ala Phe Ser Val Tyr Val Asn Asn Thr 
                405                 410                 415     


Glu Ser Tyr Ile His Arg Asn Leu Pro Thr Leu Glu Glu Tyr Asp Ser 
            420                 425                 430         


Tyr Trp Trp Leu Gly Gly Leu Val Ile Cys Ser Leu Leu Thr Leu Ile 
        435                 440                 445             


Val Ile Phe Tyr Tyr Leu Gly Leu Leu Cys Gly Val Cys Gly Tyr Asp 
    450                 455                 460                 


Arg His Ala Thr Pro Thr Thr Arg Gly Cys Val Ser Asn Thr Gly Gly 
465                 470                 475                 480 


Val Phe Leu Met Val Gly Val Gly Leu Ser Phe Leu Phe Cys Trp Ile 
                485                 490                 495     


Leu Met Ile Ile Val Val Leu Thr Phe Val Phe Gly Ala Asn Val Glu 
            500                 505                 510         


Lys Leu Ile Cys Glu Pro Tyr Thr Ser Lys Glu Leu Phe Arg Val Leu 
        515                 520                 525             


Asp Thr Pro Tyr Leu Leu Asn Glu Asp Trp Glu Tyr Tyr Leu Ser Gly 
    530                 535                 540                 


Lys Leu Phe Asn Lys Ser Lys Met Lys Leu Thr Phe Glu Gln Val Tyr 
545                 550                 555                 560 


Ser Asp Cys Lys Lys Asn Arg Gly Thr Tyr Gly Thr Leu His Leu Gln 
                565                 570                 575     


Asn Ser Phe Asn Ile Ser Glu His Leu Asn Ile Asn Glu His Thr Gly 
            580                 585                 590         


Ser Ile Ser Ser Glu Leu Glu Ser Leu Lys Val Asn Leu Asn Ile Phe 
        595                 600                 605             


Leu Leu Gly Ala Ala Gly Arg Lys Asn Leu Gln Asp Phe Ala Ala Cys 
    610                 615                 620                 


Gly Ile Asp Arg Met Asn Tyr Asp Ser Tyr Leu Ala Gln Thr Gly Lys 
625                 630                 635                 640 


Ser Pro Ala Gly Val Asn Leu Leu Ser Phe Ala Tyr Asp Leu Glu Ala 
                645                 650                 655     


Lys Ala Asn Ser Leu Pro Pro Gly Asn Leu Arg Asn Ser Leu Lys Arg 
            660                 665                 670         


Asp Ala Gln Thr Ile Lys Thr Ile His Gln Gln Arg Val Leu Pro Ile 
        675                 680                 685             


Glu Gln Ser Leu Ser Thr Leu Tyr Gln Ser Val Lys Ile Leu Gln Arg 
    690                 695                 700                 


Thr Gly Asn Gly Leu Leu Glu Arg Val Thr Arg Ile Leu Ala Ser Leu 
705                 710                 715                 720 


Asp Phe Ala Gln Asn Phe Ile Thr Asn Asn Thr Ser Ser Val Ile Ile 
                725                 730                 735     


Glu Glu Thr Lys Lys Tyr Gly Arg Thr Ile Ile Gly Tyr Phe Glu His 
            740                 745                 750         


Tyr Leu Gln Trp Ile Glu Phe Ser Ile Ser Glu Lys Val Ala Ser Cys 
        755                 760                 765             


Lys Pro Val Ala Thr Ala Leu Asp Thr Ala Val Asp Val Phe Leu Cys 
    770                 775                 780                 


Ser Tyr Ile Ile Asp Pro Leu Asn Leu Phe Trp Phe Gly Ile Gly Lys 
785                 790                 795                 800 


Ala Thr Val Phe Leu Leu Pro Ala Leu Ile Phe Ala Val Lys Leu Ala 
                805                 810                 815     


Lys Tyr Tyr Arg Arg Met Asp Ser Glu Asp Val Tyr Asp Asp Val Glu 
            820                 825                 830         


Thr Ile Pro Met Lys Asn Met Glu Asn Gly Asn Asn Gly Tyr His Lys 
        835                 840                 845             


Asp His Val Tyr Gly Ile His Asn Pro Val Met Thr Ser Pro Ser Gln 
    850                 855                 860                 


His 
865 


<210>  3416
<211>  830
<212>  PRT
<213>  Homo sapiens

<400>  3416

Met Gly Ser Met Phe Arg Ser Glu Glu Val Ala Leu Val Gln Leu Phe 
1               5                   10                  15      


Leu Pro Thr Ala Ala Ala Tyr Thr Cys Val Ser Arg Leu Gly Glu Leu 
            20                  25                  30          


Gly Leu Val Glu Phe Arg Asp Leu Asn Ala Ser Val Ser Ala Phe Gln 
        35                  40                  45              


Arg Arg Phe Val Val Asp Val Arg Arg Cys Glu Glu Leu Glu Lys Thr 
    50                  55                  60                  


Phe Thr Phe Leu Gln Glu Glu Val Arg Arg Ala Gly Leu Val Leu Pro 
65                  70                  75                  80  


Pro Pro Lys Gly Arg Leu Pro Ala Pro Pro Pro Arg Asp Leu Leu Arg 
                85                  90                  95      


Ile Gln Glu Glu Thr Glu Arg Leu Ala Gln Glu Leu Arg Asp Val Arg 
            100                 105                 110         


Gly Asn Gln Gln Ala Leu Arg Ala Gln Leu His Gln Leu Gln Leu His 
        115                 120                 125             


Ala Ala Val Leu Arg Gln Gly His Glu Pro Gln Leu Ala Ala Ala His 
    130                 135                 140                 


Thr Asp Gly Ala Ser Glu Arg Thr Pro Leu Leu Gln Ala Pro Gly Gly 
145                 150                 155                 160 


Pro His Gln Asp Leu Arg Val Asn Phe Val Ala Gly Ala Val Glu Pro 
                165                 170                 175     


His Lys Ala Pro Ala Leu Glu Arg Leu Leu Trp Arg Ala Cys Arg Gly 
            180                 185                 190         


Phe Leu Ile Ala Ser Phe Arg Glu Leu Glu Gln Pro Leu Glu His Pro 
        195                 200                 205             


Val Thr Gly Glu Pro Ala Thr Trp Met Thr Phe Leu Ile Ser Tyr Trp 
    210                 215                 220                 


Gly Glu Gln Ile Gly Gln Lys Ile Arg Lys Ile Thr Asp Cys Phe His 
225                 230                 235                 240 


Cys His Val Phe Pro Phe Leu Gln Gln Glu Glu Ala Arg Leu Gly Ala 
                245                 250                 255     


Leu Gln Gln Leu Gln Gln Gln Ser Gln Glu Leu Gln Glu Val Leu Gly 
            260                 265                 270         


Glu Thr Glu Arg Phe Leu Ser Gln Val Leu Gly Arg Val Leu Gln Leu 
        275                 280                 285             


Leu Pro Pro Gly Gln Val Gln Val His Lys Met Lys Ala Val Tyr Leu 
    290                 295                 300                 


Ala Leu Asn Gln Cys Ser Val Ser Thr Thr His Lys Cys Leu Ile Ala 
305                 310                 315                 320 


Glu Ala Trp Cys Ser Val Arg Asp Leu Pro Ala Leu Gln Glu Ala Leu 
                325                 330                 335     


Arg Asp Ser Ser Met Glu Glu Gly Val Ser Ala Val Ala His Arg Ile 
            340                 345                 350         


Pro Cys Arg Asp Met Pro Pro Thr Leu Ile Arg Thr Asn Arg Phe Thr 
        355                 360                 365             


Ala Ser Phe Gln Gly Ile Val Asp Ala Tyr Gly Val Gly Arg Tyr Gln 
    370                 375                 380                 


Glu Val Asn Pro Ala Pro Tyr Thr Ile Ile Thr Phe Pro Phe Leu Phe 
385                 390                 395                 400 


Ala Val Met Phe Gly Asp Val Gly His Gly Leu Leu Met Phe Leu Phe 
                405                 410                 415     


Ala Leu Ala Met Val Leu Ala Glu Asn Arg Pro Ala Val Lys Ala Ala 
            420                 425                 430         


Gln Asn Glu Ile Trp Gln Thr Phe Phe Arg Gly Arg Tyr Leu Leu Leu 
        435                 440                 445             


Leu Met Gly Leu Phe Ser Ile Tyr Thr Gly Phe Ile Tyr Asn Glu Cys 
    450                 455                 460                 


Phe Ser Arg Ala Thr Ser Ile Phe Pro Ser Gly Trp Ser Val Ala Ala 
465                 470                 475                 480 


Met Ala Asn Gln Ser Gly Trp Ser Asp Ala Phe Leu Ala Gln His Thr 
                485                 490                 495     


Met Leu Thr Leu Asp Pro Asn Val Thr Gly Val Phe Leu Gly Pro Tyr 
            500                 505                 510         


Pro Phe Gly Ile Asp Pro Ile Trp Ser Leu Ala Ala Asn His Leu Ser 
        515                 520                 525             


Phe Leu Asn Ser Phe Lys Met Lys Met Ser Val Ile Leu Gly Val Val 
    530                 535                 540                 


His Met Ala Phe Gly Val Val Leu Gly Val Phe Asn His Val His Phe 
545                 550                 555                 560 


Gly Gln Arg His Arg Leu Leu Leu Glu Thr Leu Pro Glu Leu Thr Phe 
                565                 570                 575     


Leu Leu Gly Leu Phe Gly Tyr Leu Val Phe Leu Val Ile Tyr Lys Trp 
            580                 585                 590         


Leu Cys Val Trp Ala Ala Arg Ala Ala Ser Ala Pro Ser Ile Leu Ile 
        595                 600                 605             


His Phe Ile Asn Met Phe Leu Phe Ser His Ser Pro Ser Asn Arg Leu 
    610                 615                 620                 


Leu Tyr Pro Arg Gln Glu Val Val Gln Ala Thr Leu Val Val Leu Ala 
625                 630                 635                 640 


Leu Ala Met Val Pro Ile Leu Leu Leu Gly Thr Pro Leu His Leu Leu 
                645                 650                 655     


His Arg His Arg Arg Arg Leu Arg Arg Arg Pro Ala Asp Arg Gln Glu 
            660                 665                 670         


Glu Asn Lys Ala Gly Leu Leu Asp Leu Pro Asp Ala Ser Val Asn Gly 
        675                 680                 685             


Trp Ser Ser Asp Glu Glu Lys Ala Gly Gly Leu Asp Asp Glu Glu Glu 
    690                 695                 700                 


Ala Glu Leu Val Pro Ser Glu Val Leu Met His Gln Ala Ile His Thr 
705                 710                 715                 720 


Ile Glu Phe Cys Leu Gly Cys Val Ser Asn Thr Ala Ser Tyr Leu Arg 
                725                 730                 735     


Leu Trp Ala Leu Ser Leu Ala His Ala Gln Leu Ser Glu Val Leu Trp 
            740                 745                 750         


Ala Met Val Met Arg Ile Gly Leu Gly Leu Gly Arg Glu Val Gly Val 
        755                 760                 765             


Ala Ala Val Val Leu Val Pro Ile Phe Ala Ala Phe Ala Val Met Thr 
    770                 775                 780                 


Val Ala Ile Leu Leu Val Met Glu Gly Leu Ser Ala Phe Leu His Ala 
785                 790                 795                 800 


Leu Arg Leu His Trp Val Glu Phe Gln Asn Lys Phe Tyr Ser Gly Thr 
                805                 810                 815     


Gly Tyr Lys Leu Ser Pro Phe Thr Phe Ala Ala Thr Asp Asp 
            820                 825                 830 


<210>  3417
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  3417

Met Leu Ser Ser Val Met Ala Pro Leu Trp Ala Cys Ile Leu Val Ala 
1               5                   10                  15      


Ala Gly Ile Leu Ala Thr Asp Thr His His Pro Gln Asp Ser Ala Leu 
            20                  25                  30          


Tyr His Leu Ser Lys Gln Leu Leu Gln Lys Tyr His Lys Glu Val Arg 
        35                  40                  45              


Pro Val Tyr Asn Trp Thr Lys Ala Thr Thr Val Tyr Leu Asp Leu Phe 
    50                  55                  60                  


Val His Ala Ile Leu Asp Val Asp Ala Glu Asn Gln Ile Leu Lys Thr 
65                  70                  75                  80  


Ser Val Trp Tyr Gln Glu Val Trp Asn Asp Glu Phe Leu Ser Trp Asn 
                85                  90                  95      


Ser Ser Met Phe Asp Glu Ile Arg Glu Ile Ser Leu Pro Leu Ser Ala 
            100                 105                 110         


Ile Trp Ala Pro Asp Ile Ile Ile Asn Glu Phe Val Asp Ile Glu Arg 
        115                 120                 125             


Tyr Pro Asp Leu Pro Tyr Val Tyr Val Asn Ser Ser Gly Thr Ile Glu 
    130                 135                 140                 


Asn Tyr Lys Pro Ile Gln Val Val Ser Ala Cys Ser Leu Glu Thr Tyr 
145                 150                 155                 160 


Ala Phe Pro Phe Asp Val Gln Asn Cys Ser Leu Thr Phe Lys Ser Ile 
                165                 170                 175     


Leu His Thr Val Glu Asp Val Asp Leu Ala Phe Leu Arg Ser Pro Glu 
            180                 185                 190         


Asp Ile Gln His Asp Lys Lys Ala Phe Leu Asn Asp Ser Glu Trp Glu 
        195                 200                 205             


Leu Leu Ser Val Ser Ser Thr Tyr Ser Ile Leu Gln Ser Ser Ala Gly 
    210                 215                 220                 


Gly Phe Ala Gln Ile Gln Phe Asn Val Val Met Arg Arg His Pro Leu 
225                 230                 235                 240 


Val Tyr Val Val Ser Leu Leu Ile Pro Ser Ile Phe Leu Met Leu Val 
                245                 250                 255     


Asp Leu Gly Ser Phe Tyr Leu Pro Pro Asn Cys Arg Ala Arg Ile Val 
            260                 265                 270         


Phe Lys Thr Ser Val Leu Val Gly Tyr Thr Val Phe Arg Val Asn Met 
        275                 280                 285             


Ser Asn Gln Val Pro Arg Ser Val Gly Ser Thr Pro Leu Ile Gly His 
    290                 295                 300                 


Phe Phe Thr Ile Cys Met Ala Phe Leu Val Leu Ser Leu Ala Lys Ser 
305                 310                 315                 320 


Ile Val Leu Val Lys Phe Leu His Asp Glu Gln Arg Gly Gly Gln Glu 
                325                 330                 335     


Gln Pro Phe Leu Cys Leu Arg Gly Asp Thr Asp Ala Asp Arg Pro Arg 
            340                 345                 350         


Val Glu Pro Arg Ala Gln Arg Ala Val Val Thr Glu Ser Ser Leu Tyr 
        355                 360                 365             


Gly Glu His Leu Ala Gln Pro Gly Thr Leu Lys Glu Val Trp Ser Gln 
    370                 375                 380                 


Leu Gln Ser Ile Ser Asn Tyr Leu Gln Thr Gln Asp Gln Thr Asp Gln 
385                 390                 395                 400 


Gln Glu Ala Glu Trp Leu Val Leu Leu Ser Arg Phe Asp Arg Leu Leu 
                405                 410                 415     


Phe Gln Ser Tyr Leu Phe Met Leu Gly Ile Tyr Thr Ile Thr Leu Cys 
            420                 425                 430         


Ser Leu Trp Ala Leu Trp Gly Gly Val 
        435                 440     


<210>  3418
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  3418

Met Gly Gln Arg Leu Ser Gly Gly Arg Ser Cys Leu Asp Val Pro Gly 
1               5                   10                  15      


Arg Leu Leu Pro Gln Pro Pro Pro Pro Pro Pro Pro Val Arg Arg Lys 
            20                  25                  30          


Leu Ala Leu Leu Phe Ala Met Leu Cys Val Trp Leu Tyr Met Phe Leu 
        35                  40                  45              


Tyr Ser Cys Ala Gly Ser Cys Ala Ala Ala Pro Gly Leu Leu Leu Leu 
    50                  55                  60                  


Gly Ser Gly Ser Arg Ala Ala His Asp Pro Pro Ala Leu Ala Thr Ala 
65                  70                  75                  80  


Pro Asp Gly Thr Pro Pro Arg Leu Pro Phe Arg Ala Pro Pro Ala Thr 
                85                  90                  95      


Pro Leu Ala Ser Gly Lys Glu Met Ala Glu Gly Ala Ala Ser Pro Glu 
            100                 105                 110         


Glu Gln Ser Pro Glu Val Pro Asp Ser Pro Ser Pro Ile Ser Ser Phe 
        115                 120                 125             


Phe Ser Gly Ser Gly Ser Lys Gln Leu Pro Gln Ala Ile Ile Ile Gly 
    130                 135                 140                 


Val Lys Lys Gly Gly Thr Arg Ala Leu Leu Glu Phe Leu Arg Val His 
145                 150                 155                 160 


Pro Asp Val Arg Ala Val Gly Ala Glu Pro His Phe Phe Asp Arg Ser 
                165                 170                 175     


Tyr Asp Lys Gly Leu Ala Trp Tyr Arg Asp Leu Met Pro Arg Thr Leu 
            180                 185                 190         


Asp Gly Gln Ile Thr Met Glu Lys Thr Pro Ser Tyr Phe Val Thr Arg 
        195                 200                 205             


Glu Ala Pro Ala Arg Ile Ser Ala Met Ser Lys Asp Thr Lys Leu Ile 
    210                 215                 220                 


Val Val Val Arg Asp Pro Val Thr Arg Ala Ile Ser Asp Tyr Thr Gln 
225                 230                 235                 240 


Thr Leu Ser Lys Arg Pro Asp Ile Pro Thr Phe Glu Ser Leu Thr Phe 
                245                 250                 255     


Lys Asn Arg Thr Ala Gly Leu Ile Asp Thr Ser Trp Ser Ala Ile Gln 
            260                 265                 270         


Ile Gly Ile Tyr Ala Lys His Leu Glu His Trp Leu Arg His Phe Pro 
        275                 280                 285             


Ile Arg Gln Met Leu Phe Val Ser Gly Glu Arg Leu Ile Ser Asp Pro 
    290                 295                 300                 


Ala Gly Glu Leu Gly Arg Val Gln Asp Phe Leu Gly Leu Lys Arg Ile 
305                 310                 315                 320 


Ile Thr Asp Lys His Phe Tyr Phe Asn Lys Thr Lys Gly Phe Pro Cys 
                325                 330                 335     


Leu Lys Lys Ala Glu Gly Ser Ser Arg Pro His Cys Leu Gly Lys Thr 
            340                 345                 350         


Lys Gly Arg Thr His Pro Glu Ile Asp Arg Glu Val Val Arg Arg Leu 
        355                 360                 365             


Arg Glu Phe Tyr Arg Pro Phe Asn Leu Lys Phe Tyr Gln Met Thr Gly 
    370                 375                 380                 


His Asp Phe Gly Trp Asp 
385                 390 


<210>  3419
<211>  367
<212>  PRT
<213>  Homo sapiens

<400>  3419

Met Ala Tyr Arg Val Leu Gly Arg Ala Gly Pro Pro Gln Pro Arg Arg 
1               5                   10                  15      


Ala Arg Arg Leu Leu Phe Ala Phe Thr Leu Ser Leu Ser Cys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Ser Phe Leu Cys Cys Cys Asp Asp Leu Gly Arg Ser Arg 
        35                  40                  45              


Leu Leu Gly Ala Pro Arg Cys Leu Arg Gly Pro Ser Ala Gly Gly Gln 
    50                  55                  60                  


Lys Leu Leu Gln Lys Ser Arg Pro Cys Asp Pro Ser Gly Pro Thr Pro 
65                  70                  75                  80  


Ser Glu Pro Ser Ala Pro Ser Ala Pro Ala Ala Ala Val Pro Ala Pro 
                85                  90                  95      


Arg Leu Ser Gly Ser Asn His Ser Gly Ser Pro Lys Leu Gly Thr Lys 
            100                 105                 110         


Arg Leu Pro Gln Ala Leu Ile Val Gly Val Lys Lys Gly Gly Thr Arg 
        115                 120                 125             


Ala Val Leu Glu Phe Ile Arg Val His Pro Asp Val Arg Ala Leu Gly 
    130                 135                 140                 


Thr Glu Pro His Phe Phe Asp Arg Asn Tyr Gly Arg Gly Leu Asp Trp 
145                 150                 155                 160 


Tyr Arg Ser Leu Met Pro Arg Thr Leu Glu Ser Gln Ile Thr Leu Glu 
                165                 170                 175     


Lys Thr Pro Ser Tyr Phe Val Thr Gln Glu Ala Pro Arg Arg Ile Phe 
            180                 185                 190         


Asn Met Ser Arg Asp Thr Lys Leu Ile Val Val Val Arg Asn Pro Val 
        195                 200                 205             


Thr Arg Ala Ile Ser Asp Tyr Thr Gln Thr Leu Ser Lys Lys Pro Asp 
    210                 215                 220                 


Ile Pro Thr Phe Glu Gly Leu Ser Phe Arg Asn Arg Thr Leu Gly Leu 
225                 230                 235                 240 


Val Asp Val Ser Trp Asn Ala Ile Arg Ile Gly Met Tyr Val Leu His 
                245                 250                 255     


Leu Glu Ser Trp Leu Gln Tyr Phe Pro Leu Ala Gln Ile His Phe Val 
            260                 265                 270         


Ser Gly Glu Arg Leu Ile Thr Asp Pro Ala Gly Glu Met Gly Arg Val 
        275                 280                 285             


Gln Asp Phe Leu Gly Ile Lys Arg Phe Ile Thr Asp Lys His Phe Tyr 
    290                 295                 300                 


Phe Asn Lys Thr Lys Gly Phe Pro Cys Leu Lys Lys Thr Glu Ser Ser 
305                 310                 315                 320 


Leu Leu Pro Arg Cys Leu Gly Lys Ser Lys Gly Arg Thr His Val Gln 
                325                 330                 335     


Ile Asp Pro Glu Val Ile Asp Gln Leu Arg Glu Phe Tyr Arg Pro Tyr 
            340                 345                 350         


Asn Ile Lys Phe Tyr Glu Thr Val Gly Gln Asp Phe Arg Trp Glu 
        355                 360                 365         


<210>  3420
<211>  1047
<212>  PRT
<213>  Homo sapiens

<400>  3420

Met Thr Asp Asn Ile Pro Leu Gln Pro Val Arg Gln Lys Lys Arg Met 
1               5                   10                  15      


Asp Ser Arg Pro Arg Ala Gly Cys Cys Glu Trp Leu Arg Cys Cys Gly 
            20                  25                  30          


Gly Gly Glu Ala Arg Pro Arg Thr Val Trp Leu Gly His Pro Glu Lys 
        35                  40                  45              


Arg Asp Gln Arg Tyr Pro Arg Asn Val Ile Asn Asn Gln Lys Tyr Asn 
    50                  55                  60                  


Phe Phe Thr Phe Leu Pro Gly Val Leu Phe Asn Gln Phe Lys Tyr Phe 
65                  70                  75                  80  


Phe Asn Leu Tyr Phe Leu Leu Leu Ala Cys Ser Gln Phe Val Pro Glu 
                85                  90                  95      


Met Arg Leu Gly Ala Leu Tyr Thr Tyr Trp Val Pro Leu Gly Phe Val 
            100                 105                 110         


Leu Ala Val Thr Val Ile Arg Glu Ala Val Glu Glu Ile Arg Cys Tyr 
        115                 120                 125             


Val Arg Asp Lys Glu Val Asn Ser Gln Val Tyr Ser Arg Leu Thr Ala 
    130                 135                 140                 


Arg Gly Thr Val Lys Val Lys Ser Ser Asn Ile Gln Val Gly Asp Leu 
145                 150                 155                 160 


Ile Ile Val Glu Lys Asn Gln Arg Val Pro Ala Asp Met Ile Phe Leu 
                165                 170                 175     


Arg Thr Ser Glu Lys Asn Gly Ser Cys Phe Leu Arg Thr Asp Gln Leu 
            180                 185                 190         


Asp Gly Glu Thr Asp Trp Lys Leu Arg Leu Pro Val Ala Cys Thr Gln 
        195                 200                 205             


Arg Leu Pro Thr Ala Ala Asp Leu Leu Gln Ile Arg Ser Tyr Val Tyr 
    210                 215                 220                 


Ala Glu Glu Pro Asn Ile Asp Ile His Asn Phe Val Gly Thr Phe Thr 
225                 230                 235                 240 


Arg Glu Asp Ser Asp Pro Pro Ile Ser Glu Ser Leu Ser Ile Glu Asn 
                245                 250                 255     


Thr Leu Trp Ala Gly Thr Val Val Ala Ser Gly Thr Val Val Gly Val 
            260                 265                 270         


Val Leu Tyr Thr Gly Arg Glu Leu Arg Ser Val Met Asn Thr Ser Asn 
        275                 280                 285             


Pro Arg Ser Lys Ile Gly Leu Phe Asp Leu Glu Val Asn Cys Leu Thr 
    290                 295                 300                 


Lys Ile Leu Phe Gly Ala Leu Val Val Val Ser Leu Val Met Val Ala 
305                 310                 315                 320 


Leu Gln His Phe Ala Gly Arg Trp Tyr Leu Gln Ile Ile Arg Phe Leu 
                325                 330                 335     


Leu Leu Phe Ser Asn Ile Ile Pro Ile Ser Leu Arg Val Asn Leu Asp 
            340                 345                 350         


Met Gly Lys Ile Val Tyr Ser Trp Val Ile Arg Arg Asp Ser Lys Ile 
        355                 360                 365             


Pro Gly Thr Val Val Arg Ser Ser Thr Ile Pro Glu Gln Leu Gly Arg 
    370                 375                 380                 


Ile Ser Tyr Leu Leu Thr Asp Lys Thr Gly Thr Leu Thr Gln Asn Glu 
385                 390                 395                 400 


Met Ile Phe Lys Arg Leu His Leu Gly Thr Val Ala Tyr Gly Leu Asp 
                405                 410                 415     


Ser Met Asp Glu Val Gln Ser His Ile Phe Ser Ile Tyr Thr Gln Gln 
            420                 425                 430         


Ser Gln Asp Pro Pro Ala Gln Lys Gly Pro Thr Leu Thr Thr Lys Val 
        435                 440                 445             


Arg Arg Thr Met Ser Ser Arg Val His Glu Ala Val Lys Ala Ile Ala 
    450                 455                 460                 


Leu Cys His Asn Val Thr Pro Val Tyr Glu Ser Asn Gly Val Thr Asp 
465                 470                 475                 480 


Gln Ala Glu Ala Glu Lys Gln Tyr Glu Asp Ser Cys Arg Val Tyr Gln 
                485                 490                 495     


Ala Ser Ser Pro Asp Glu Val Ala Leu Val Gln Trp Thr Glu Ser Val 
            500                 505                 510         


Gly Leu Thr Leu Val Gly Arg Asp Gln Ser Ser Met Gln Leu Arg Thr 
        515                 520                 525             


Pro Gly Asp Gln Ile Leu Asn Phe Thr Ile Leu Gln Ile Phe Pro Phe 
    530                 535                 540                 


Thr Tyr Glu Ser Lys Arg Met Gly Ile Ile Val Arg Asp Glu Ser Thr 
545                 550                 555                 560 


Gly Glu Ile Thr Phe Tyr Met Lys Gly Ala Asp Val Val Met Ala Gly 
                565                 570                 575     


Ile Val Gln Tyr Asn Asp Trp Leu Glu Glu Glu Cys Gly Asn Met Ala 
            580                 585                 590         


Arg Glu Gly Leu Arg Val Leu Val Val Ala Lys Lys Ser Leu Ala Glu 
        595                 600                 605             


Glu Gln Tyr Gln Asp Phe Glu Ala Arg Tyr Val Gln Ala Lys Leu Ser 
    610                 615                 620                 


Val His Asp Arg Ser Leu Lys Val Ala Thr Val Ile Glu Ser Leu Glu 
625                 630                 635                 640 


Met Glu Met Glu Leu Leu Cys Leu Thr Gly Val Glu Asp Gln Leu Gln 
                645                 650                 655     


Ala Asp Val Arg Pro Thr Leu Glu Thr Leu Arg Asn Ala Gly Ile Lys 
            660                 665                 670         


Val Trp Met Leu Thr Gly Asp Lys Leu Glu Thr Ala Thr Cys Thr Ala 
        675                 680                 685             


Lys Asn Ala His Leu Val Thr Arg Asn Gln Asp Ile His Val Phe Arg 
    690                 695                 700                 


Leu Val Thr Asn Arg Gly Glu Ala His Leu Glu Leu Asn Ala Phe Arg 
705                 710                 715                 720 


Arg Lys His Asp Cys Ala Leu Val Ile Ser Gly Asp Ser Leu Glu Val 
                725                 730                 735     


Cys Leu Lys Tyr Tyr Glu Tyr Glu Phe Met Glu Leu Ala Cys Gln Cys 
            740                 745                 750         


Pro Ala Val Val Cys Cys Arg Cys Ala Pro Thr Gln Lys Ala Gln Ile 
        755                 760                 765             


Val Arg Leu Leu Gln Glu Arg Thr Gly Lys Leu Thr Cys Ala Val Gly 
    770                 775                 780                 


Asp Gly Gly Asn Asp Val Ser Met Ile Gln Glu Ser Asp Cys Gly Val 
785                 790                 795                 800 


Gly Val Glu Gly Lys Glu Gly Lys Gln Ala Ser Leu Ala Ala Asp Phe 
                805                 810                 815     


Ser Ile Thr Gln Phe Lys His Leu Gly Arg Leu Leu Met Val His Gly 
            820                 825                 830         


Arg Asn Ser Tyr Lys Arg Ser Ala Ala Leu Ser Gln Phe Val Ile His 
        835                 840                 845             


Arg Ser Leu Cys Ile Ser Thr Met Gln Ala Val Phe Ser Ser Val Phe 
    850                 855                 860                 


Tyr Phe Ala Ser Val Pro Leu Tyr Gln Gly Phe Leu Ile Ile Gly Tyr 
865                 870                 875                 880 


Ser Thr Ile Tyr Thr Met Phe Pro Val Phe Ser Leu Val Leu Asp Lys 
                885                 890                 895     


Asp Val Lys Ser Glu Val Ala Met Leu Tyr Pro Glu Leu Tyr Lys Asp 
            900                 905                 910         


Leu Leu Lys Gly Arg Pro Leu Ser Tyr Lys Thr Phe Leu Ile Trp Val 
        915                 920                 925             


Leu Ile Ser Ile Tyr Gln Gly Ser Thr Ile Met Tyr Gly Ala Leu Leu 
    930                 935                 940                 


Leu Phe Glu Ser Glu Phe Val His Ile Val Ala Ile Ser Phe Thr Ser 
945                 950                 955                 960 


Leu Ile Leu Thr Glu Leu Leu Met Val Ala Leu Thr Ile Gln Thr Trp 
                965                 970                 975     


His Trp Leu Met Thr Val Ala Glu Leu Leu Ser Leu Ala Cys Tyr Ile 
            980                 985                 990         


Ala Ser Leu Val Phe Leu His Glu  Phe Ile Asp Val Tyr  Phe Ile Ala 
        995                 1000                 1005             


Thr Leu  Ser Phe Leu Trp Lys  Val Ser Val Ile Thr  Leu Val Ser 
    1010                 1015                 1020             


Cys Leu  Pro Leu Tyr Val Leu  Lys Tyr Leu Arg Arg  Arg Phe Ser 
    1025                 1030                 1035             


Pro Pro  Ser Tyr Ser Lys Leu  Thr Ser 
    1040                 1045         


<210>  3421
<211>  614
<212>  PRT
<213>  Homo sapiens

<400>  3421

Met Thr Phe Leu Ile Ser Tyr Trp Gly Glu Gln Ile Gly Gln Lys Ile 
1               5                   10                  15      


Arg Lys Ile Thr Asp Cys Phe His Cys His Val Phe Pro Phe Leu Gln 
            20                  25                  30          


Gln Glu Glu Ala Arg Leu Gly Ala Leu Gln Gln Leu Gln Gln Gln Ser 
        35                  40                  45              


Gln Glu Leu Gln Glu Val Leu Gly Glu Thr Glu Arg Phe Leu Ser Gln 
    50                  55                  60                  


Val Leu Gly Arg Val Leu Gln Leu Leu Pro Pro Gly Gln Val Gln Val 
65                  70                  75                  80  


His Lys Met Lys Ala Val Tyr Leu Ala Leu Asn Gln Cys Ser Val Ser 
                85                  90                  95      


Thr Thr His Lys Cys Leu Ile Ala Glu Ala Trp Cys Ser Val Arg Asp 
            100                 105                 110         


Leu Pro Ala Leu Gln Glu Ala Leu Arg Asp Ser Ser Met Glu Glu Gly 
        115                 120                 125             


Val Ser Ala Val Ala His Arg Ile Pro Cys Arg Asp Met Pro Pro Thr 
    130                 135                 140                 


Leu Ile Arg Thr Asn Arg Phe Thr Ala Ser Phe Gln Gly Ile Val Asp 
145                 150                 155                 160 


Ala Tyr Gly Val Gly Arg Tyr Gln Glu Val Asn Pro Ala Pro Tyr Thr 
                165                 170                 175     


Ile Ile Thr Phe Pro Phe Leu Phe Ala Val Met Phe Gly Asp Val Gly 
            180                 185                 190         


His Gly Leu Leu Met Phe Leu Phe Ala Leu Ala Met Val Leu Ala Glu 
        195                 200                 205             


Asn Arg Pro Ala Val Lys Ala Ala Gln Asn Glu Ile Trp Gln Thr Phe 
    210                 215                 220                 


Phe Arg Gly Arg Tyr Leu Leu Leu Leu Met Gly Leu Phe Ser Ile Tyr 
225                 230                 235                 240 


Thr Gly Phe Ile Tyr Asn Glu Cys Phe Ser Arg Ala Thr Ser Ile Phe 
                245                 250                 255     


Pro Ser Gly Trp Ser Val Ala Ala Met Ala Asn Gln Ser Gly Trp Ser 
            260                 265                 270         


Asp Ala Phe Leu Ala Gln His Thr Met Leu Thr Leu Asp Pro Asn Val 
        275                 280                 285             


Thr Gly Val Phe Leu Gly Pro Tyr Pro Phe Gly Ile Asp Pro Ile Trp 
    290                 295                 300                 


Ser Leu Ala Ala Asn His Leu Ser Phe Leu Asn Ser Phe Lys Met Lys 
305                 310                 315                 320 


Met Ser Val Ile Leu Gly Val Val His Met Ala Phe Gly Val Val Leu 
                325                 330                 335     


Gly Val Phe Asn His Val His Phe Gly Gln Arg His Arg Leu Leu Leu 
            340                 345                 350         


Glu Thr Leu Pro Glu Leu Thr Phe Leu Leu Gly Leu Phe Gly Tyr Leu 
        355                 360                 365             


Val Phe Leu Val Ile Tyr Lys Trp Leu Cys Val Trp Ala Ala Arg Ala 
    370                 375                 380                 


Ala Ser Ala Pro Ser Ile Leu Ile His Phe Ile Asn Met Phe Leu Phe 
385                 390                 395                 400 


Ser His Ser Pro Ser Asn Arg Leu Leu Tyr Pro Arg Gln Glu Val Val 
                405                 410                 415     


Gln Ala Thr Leu Val Val Leu Ala Leu Ala Met Val Pro Ile Leu Leu 
            420                 425                 430         


Leu Gly Thr Pro Leu His Leu Leu His Arg His Arg Arg Arg Leu Arg 
        435                 440                 445             


Arg Arg Pro Ala Asp Arg Gln Glu Glu Asn Lys Ala Gly Leu Leu Asp 
    450                 455                 460                 


Leu Pro Asp Ala Ser Val Asn Gly Trp Ser Ser Asp Glu Glu Lys Ala 
465                 470                 475                 480 


Gly Gly Leu Asp Asp Glu Glu Glu Ala Glu Leu Val Pro Ser Glu Val 
                485                 490                 495     


Leu Met His Gln Ala Ile His Thr Ile Glu Phe Cys Leu Gly Cys Val 
            500                 505                 510         


Ser Asn Thr Ala Ser Tyr Leu Arg Leu Trp Ala Leu Ser Leu Ala His 
        515                 520                 525             


Ala Gln Leu Ser Glu Val Leu Trp Ala Met Val Met Arg Ile Gly Leu 
    530                 535                 540                 


Gly Leu Gly Arg Glu Val Gly Val Ala Ala Val Val Leu Val Pro Ile 
545                 550                 555                 560 


Phe Ala Ala Phe Ala Val Met Thr Val Ala Ile Leu Leu Val Met Glu 
                565                 570                 575     


Gly Leu Ser Ala Phe Leu His Ala Leu Arg Leu His Trp Val Glu Phe 
            580                 585                 590         


Gln Asn Lys Phe Tyr Ser Gly Thr Gly Tyr Lys Leu Ser Pro Phe Thr 
        595                 600                 605             


Phe Ala Ala Thr Asp Asp 
    610                 


<210>  3422
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  3422

Met Ala Glu Pro Ser Ala Ala Thr Gln Ser His Ser Ile Ser Ser Ser 
1               5                   10                  15      


Ser Phe Gly Ala Glu Pro Ser Ala Pro Gly Gly Gly Gly Ser Pro Gly 
            20                  25                  30          


Ala Cys Pro Ala Leu Gly Thr Lys Ser Cys Ser Ser Ser Cys Ala Val 
        35                  40                  45              


His Asp Leu Ile Phe Trp Arg Asp Val Lys Lys Thr Gly Phe Val Phe 
    50                  55                  60                  


Gly Thr Thr Leu Ile Met Leu Leu Ser Leu Ala Ala Phe Ser Val Ile 
65                  70                  75                  80  


Ser Val Val Ser Tyr Leu Ile Leu Ala Leu Leu Ser Val Thr Ile Ser 
                85                  90                  95      


Phe Arg Ile Tyr Lys Ser Val Ile Gln Ala Val Gln Lys Ser Glu Glu 
            100                 105                 110         


Gly His Pro Phe Lys Ala Tyr Leu Asp Val Asp Ile Thr Leu Ser Ser 
        115                 120                 125             


Glu Ala Phe His Asn Tyr Met Asn Ala Ala Met Val His Ile Asn Arg 
    130                 135                 140                 


Ala Leu Lys Leu Ile Ile Arg Leu Phe Leu Val Glu Asp Leu Val Asp 
145                 150                 155                 160 


Ser Leu Lys Leu Ala Val Phe Met Trp Leu Met Thr Tyr Val Gly Ala 
                165                 170                 175     


Val Phe Asn Gly Ile Thr Leu Leu Ile Leu Ala Glu Leu Leu Ile Phe 
            180                 185                 190         


Ser Val Pro Ile Val Tyr Glu Lys Tyr Lys Thr Gln Ile Asp His Tyr 
        195                 200                 205             


Val Gly Ile Ala Arg Asp Gln Thr Lys Ser Ile Val Glu Lys Ile Gln 
    210                 215                 220                 


Ala Lys Leu Pro Gly Ile Ala Lys Lys Lys Ala Glu 
225                 230                 235     


<210>  3423
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  3423

Met Thr Pro Leu Cys Leu Asn Cys Ser Val Leu Pro Gly Asp Leu Tyr 
1               5                   10                  15      


Pro Gly Gly Ala Arg Asn Pro Met Ala Cys Asn Gly Ser Ala Ala Arg 
            20                  25                  30          


Gly His Phe Asp Pro Glu Asp Leu Asn Leu Thr Asp Glu Ala Leu Arg 
        35                  40                  45              


Leu Lys Tyr Leu Gly Pro Gln Gln Thr Glu Leu Phe Met Pro Ile Cys 
    50                  55                  60                  


Ala Thr Tyr Leu Leu Ile Phe Val Val Gly Ala Val Gly Asn Gly Leu 
65                  70                  75                  80  


Thr Cys Leu Val Ile Leu Arg His Lys Ala Met Arg Thr Pro Thr Asn 
                85                  90                  95      


Tyr Tyr Leu Phe Ser Leu Ala Val Ser Asp Leu Leu Val Leu Leu Val 
            100                 105                 110         


Gly Leu Pro Leu Glu Leu Tyr Glu Met Trp His Asn Tyr Pro Phe Leu 
        115                 120                 125             


Leu Gly Val Gly Gly Cys Tyr Phe Arg Thr Leu Leu Phe Glu Met Val 
    130                 135                 140                 


Cys Leu Ala Ser Val Leu Asn Val Thr Ala Leu Ser Val Glu Arg Tyr 
145                 150                 155                 160 


Val Ala Val Val His Pro Leu Gln Ala Arg Ser Met Val Thr Arg Ala 
                165                 170                 175     


His Val Arg Arg Val Leu Gly Ala Val Trp Gly Leu Ala Met Leu Cys 
            180                 185                 190         


Ser Leu Pro Asn Thr Ser Leu His Gly Ile Arg Gln Leu His Val Pro 
        195                 200                 205             


Cys Arg Gly Pro Val Pro Asp Ser Ala Val Cys Met Leu Val Arg Pro 
    210                 215                 220                 


Arg Ala Leu Tyr Asn Met Val Val Gln Thr Thr Ala Leu Leu Phe Phe 
225                 230                 235                 240 


Cys Leu Pro Met Ala Ile Met Ser Val Leu Tyr Leu Leu Ile Gly Leu 
                245                 250                 255     


Arg Leu Arg Arg Glu Arg Leu Leu Leu Met Gln Glu Ala Lys Gly Arg 
            260                 265                 270         


Gly Ser Ala Ala Ala Arg Ser Arg Tyr Thr Cys Arg Leu Gln Gln His 
        275                 280                 285             


Asp Arg Gly Arg Arg Gln Val Thr Lys Met Leu Phe Val Leu Val Val 
    290                 295                 300                 


Val Phe Gly Ile Cys Trp Ala Pro Phe His Ala Asp Arg Val Met Trp 
305                 310                 315                 320 


Ser Val Val Ser Gln Trp Thr Asp Gly Leu His Leu Ala Phe Gln His 
                325                 330                 335     


Val His Val Ile Ser Gly Ile Phe Phe Tyr Leu Gly Ser Ala Ala Asn 
            340                 345                 350         


Pro Val Leu Tyr Ser Leu Met Ser Ser Arg Phe Arg Glu Thr Phe Gln 
        355                 360                 365             


Glu Ala Leu Cys Leu Gly Ala Cys Cys His Arg Leu Arg Pro Arg His 
    370                 375                 380                 


Ser Ser His Ser Leu Ser Arg Met Thr Thr Gly Ser Thr Leu Cys Asp 
385                 390                 395                 400 


Val Gly Ser Leu Gly Ser Trp Val His Pro Leu Ala Gly Asn Asp Gly 
                405                 410                 415     


Pro Glu Ala Gln Gln Glu Thr Asp Pro Ser 
            420                 425     


<210>  3424
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  3424

Met Ala Phe Pro Lys Met Arg Leu Met Tyr Ile Cys Leu Leu Val Leu 
1               5                   10                  15      


Gly Ala Leu Cys Leu Tyr Phe Ser Met Tyr Ser Leu Asn Pro Phe Lys 
            20                  25                  30          


Glu Gln Ser Phe Val Tyr Lys Lys Asp Gly Asn Phe Leu Lys Leu Pro 
        35                  40                  45              


Asp Thr Asp Cys Arg Gln Thr Pro Pro Phe Leu Val Leu Leu Val Thr 
    50                  55                  60                  


Ser Ser His Lys Gln Leu Ala Glu Arg Met Ala Ile Arg Gln Thr Trp 
65                  70                  75                  80  


Gly Lys Glu Arg Met Val Lys Gly Lys Gln Leu Lys Thr Phe Phe Leu 
                85                  90                  95      


Leu Gly Thr Thr Ser Ser Ala Ala Glu Thr Lys Glu Val Asp Gln Glu 
            100                 105                 110         


Ser Gln Arg His Gly Asp Ile Ile Gln Lys Asp Phe Leu Asp Val Tyr 
        115                 120                 125             


Tyr Asn Leu Thr Leu Lys Thr Met Met Gly Ile Glu Trp Val His Arg 
    130                 135                 140                 


Phe Cys Pro Gln Ala Ala Phe Val Met Lys Thr Asp Ser Asp Met Phe 
145                 150                 155                 160 


Ile Asn Val Asp Tyr Leu Thr Glu Leu Leu Leu Lys Lys Asn Arg Thr 
                165                 170                 175     


Thr Arg Phe Phe Thr Gly Phe Leu Lys Leu Asn Glu Phe Pro Ile Arg 
            180                 185                 190         


Gln Pro Phe Ser Lys Trp Phe Val Ser Lys Ser Glu Tyr Pro Trp Asp 
        195                 200                 205             


Arg Tyr Pro Pro Phe Cys Ser Gly Thr Gly Tyr Val Phe Ser Gly Asp 
    210                 215                 220                 


Val Ala Ser Gln Val Tyr Asn Val Ser Lys Ser Val Pro Tyr Ile Lys 
225                 230                 235                 240 


Leu Glu Asp Val Phe Val Gly Leu Cys Leu Glu Arg Leu Asn Ile Arg 
                245                 250                 255     


Leu Glu Glu Leu His Ser Gln Pro Thr Phe Phe Pro Gly Gly Leu Arg 
            260                 265                 270         


Phe Ser Val Cys Leu Phe Arg Arg Ile Val Ala Cys His Phe Ile Lys 
        275                 280                 285             


Pro Arg Thr Leu Leu Asp Tyr Trp Gln Ala Leu Glu Asn Ser Arg Gly 
    290                 295                 300                 


Glu Asp Cys Pro Pro Val 
305                 310 


<210>  3425
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  3425

Met Lys Gln Ile Leu His Pro Ala Leu Glu Thr Thr Ala Met Thr Leu 
1               5                   10                  15      


Phe Pro Val Leu Leu Phe Leu Val Ala Gly Leu Leu Pro Ser Phe Pro 
            20                  25                  30          


Ala Asn Glu Asp Lys Asp Pro Ala Phe Thr Ala Leu Leu Thr Thr Gln 
        35                  40                  45              


Thr Gln Val Gln Arg Glu Ile Val Asn Lys His Asn Glu Leu Arg Arg 
    50                  55                  60                  


Ala Val Ser Pro Pro Ala Arg Asn Met Leu Lys Met Glu Trp Asn Lys 
65                  70                  75                  80  


Glu Ala Ala Ala Asn Ala Gln Lys Trp Ala Asn Gln Cys Asn Tyr Arg 
                85                  90                  95      


His Ser Asn Pro Lys Asp Arg Met Thr Ser Leu Lys Cys Gly Glu Asn 
            100                 105                 110         


Leu Tyr Met Ser Ser Ala Ser Ser Ser Trp Ser Gln Ala Ile Gln Ser 
        115                 120                 125             


Trp Phe Asp Glu Tyr Asn Asp Phe Asp Phe Gly Val Gly Pro Lys Thr 
    130                 135                 140                 


Pro Asn Ala Val Val Gly His Tyr Thr Gln Val Val Trp Tyr Ser Ser 
145                 150                 155                 160 


Tyr Leu Val Gly Cys Gly Asn Ala Tyr Cys Pro Asn Gln Lys Val Leu 
                165                 170                 175     


Lys Tyr Tyr Tyr Val Cys Gln Tyr Cys Pro Ala Gly Asn Trp Ala Asn 
            180                 185                 190         


Arg Leu Tyr Val Pro Tyr Glu Gln Gly Ala Pro Cys Ala Ser Cys Pro 
        195                 200                 205             


Asp Asn Cys Asp Asp Gly Leu Cys Thr Asn Gly Cys Lys Tyr Glu Asp 
    210                 215                 220                 


Leu Tyr Ser Asn Cys Lys Ser Leu Lys Leu Thr Leu Thr Cys Lys His 
225                 230                 235                 240 


Gln Leu Val Arg Asp Ser Cys Lys Ala Ser Cys Asn Cys Ser Asn Ser 
                245                 250                 255     


Ile Tyr 
        


<210>  3426
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  3426

Met Pro Val Pro Ala Ser Trp Pro His Leu Pro Ser Pro Phe Leu Leu 
1               5                   10                  15      


Met Thr Leu Leu Leu Gly Arg Leu Thr Gly Val Ala Gly Glu Asp Glu 
            20                  25                  30          


Leu Gln Val Ile Gln Pro Glu Lys Ser Val Ser Val Ala Ala Gly Glu 
        35                  40                  45              


Ser Ala Thr Leu Arg Cys Ala Met Thr Ser Leu Ile Pro Val Gly Pro 
    50                  55                  60                  


Ile Met Trp Phe Arg Gly Ala Gly Ala Gly Arg Glu Leu Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Glu Leu Thr 
                85                  90                  95      


Lys Arg Asn Asn Leu Asp Phe Ser Ile Ser Ile Ser Asn Ile Thr Pro 
            100                 105                 110         


Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser Pro 
        115                 120                 125             


Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val Arg 
    130                 135                 140                 


Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Val Arg Ala Thr 
145                 150                 155                 160 


Pro Glu His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro 
                165                 170                 175     


Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp 
            180                 185                 190         


Phe Gln Thr Asn Val Asp Pro Ala Gly Asp Ser Val Ser Tyr Ser Ile 
        195                 200                 205             


His Ser Thr Ala Arg Val Val Leu Thr Arg Gly Asp Val His Ser Gln 
    210                 215                 220                 


Val Ile Cys Glu Ile Ala His Ile Thr Leu Gln Gly Asp Pro Leu Arg 
225                 230                 235                 240 


Gly Thr Ala Asn Leu Ser Glu Ala Ile Arg Val Pro Pro Thr Leu Glu 
                245                 250                 255     


Val Thr Gln Gln Pro Met Arg Ala Glu Asn Gln Ala Asn Val Thr Cys 
            260                 265                 270         


Gln Val Ser Asn Phe Tyr Pro Arg Gly Leu Gln Leu Thr Trp Leu Glu 
        275                 280                 285             


Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Leu Ile Glu Asn 
    290                 295                 300                 


Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Thr Cys 
305                 310                 315                 320 


Ala His Arg Asp Asp Val Val Leu Thr Cys Gln Val Glu His Asp Gly 
                325                 330                 335     


Gln Gln Ala Val Ser Lys Ser Tyr Ala Leu Glu Ile Ser Ala His Gln 
            340                 345                 350         


Lys Glu His Gly Ser Asp Ile Thr His Glu Ala Ala Leu Ala Pro Thr 
        355                 360                 365             


Ala Pro Leu Leu Val Ala Leu Leu Leu Gly Pro Lys Leu Leu Leu Val 
    370                 375                 380                 


Val Gly Val Ser Ala Ile Tyr Ile Cys Trp Lys Gln Lys Ala 
385                 390                 395             


<210>  3427
<211>  796
<212>  PRT
<213>  Homo sapiens

<400>  3427

Met Thr Lys Asp Lys Glu Pro Ile Val Lys Ser Phe His Phe Val Cys 
1               5                   10                  15      


Leu Met Ile Ile Ile Val Gly Thr Arg Ile Gln Phe Ser Asp Gly Asn 
            20                  25                  30          


Glu Phe Ala Val Asp Lys Ser Lys Arg Gly Leu Ile His Val Pro Lys 
        35                  40                  45              


Asp Leu Pro Leu Lys Thr Lys Val Leu Asp Met Ser Gln Asn Tyr Ile 
    50                  55                  60                  


Ala Glu Leu Gln Val Ser Asp Met Ser Phe Leu Ser Glu Leu Thr Val 
65                  70                  75                  80  


Leu Arg Leu Ser His Asn Arg Ile Gln Leu Leu Asp Leu Ser Val Phe 
                85                  90                  95      


Lys Phe Asn Gln Asp Leu Glu Tyr Leu Asp Leu Ser His Asn Gln Leu 
            100                 105                 110         


Gln Lys Ile Ser Cys His Pro Ile Val Ser Phe Arg His Leu Asp Leu 
        115                 120                 125             


Ser Phe Asn Asp Phe Lys Ala Leu Pro Ile Cys Lys Glu Phe Gly Asn 
    130                 135                 140                 


Leu Ser Gln Leu Asn Phe Leu Gly Leu Ser Ala Met Lys Leu Gln Lys 
145                 150                 155                 160 


Leu Asp Leu Leu Pro Ile Ala His Leu His Leu Ser Tyr Ile Leu Leu 
                165                 170                 175     


Asp Leu Arg Asn Tyr Tyr Ile Lys Glu Asn Glu Thr Glu Ser Leu Gln 
            180                 185                 190         


Ile Leu Asn Ala Lys Thr Leu His Leu Val Phe His Pro Thr Ser Leu 
        195                 200                 205             


Phe Ala Ile Gln Val Asn Ile Ser Val Asn Thr Leu Gly Cys Leu Gln 
    210                 215                 220                 


Leu Thr Asn Ile Lys Leu Asn Asp Asp Asn Cys Gln Val Phe Ile Lys 
225                 230                 235                 240 


Phe Leu Ser Glu Leu Thr Arg Gly Ser Thr Leu Leu Asn Phe Thr Leu 
                245                 250                 255     


Asn His Ile Glu Thr Thr Trp Lys Cys Leu Val Arg Val Phe Gln Phe 
            260                 265                 270         


Leu Trp Pro Lys Pro Val Glu Tyr Leu Asn Ile Tyr Asn Leu Thr Ile 
        275                 280                 285             


Ile Glu Ser Ile Arg Glu Glu Asp Phe Thr Tyr Ser Lys Thr Thr Leu 
    290                 295                 300                 


Lys Ala Leu Thr Ile Glu His Ile Thr Asn Gln Val Phe Leu Phe Ser 
305                 310                 315                 320 


Gln Thr Ala Leu Tyr Thr Val Phe Ser Glu Met Asn Ile Met Met Leu 
                325                 330                 335     


Thr Ile Ser Asp Thr Pro Phe Ile His Met Leu Cys Pro His Ala Pro 
            340                 345                 350         


Ser Thr Phe Lys Phe Leu Asn Phe Thr Gln Asn Val Phe Thr Asp Ser 
        355                 360                 365             


Ile Phe Glu Lys Cys Ser Thr Leu Val Lys Leu Glu Thr Leu Ile Leu 
    370                 375                 380                 


Gln Lys Asn Gly Leu Lys Asp Leu Phe Lys Val Gly Leu Met Thr Lys 
385                 390                 395                 400 


Asp Met Pro Ser Leu Glu Ile Leu Asp Val Ser Trp Asn Ser Leu Glu 
                405                 410                 415     


Ser Gly Arg His Lys Glu Asn Cys Thr Trp Val Glu Ser Ile Val Val 
            420                 425                 430         


Leu Asn Leu Ser Ser Asn Met Leu Thr Asp Ser Val Phe Arg Cys Leu 
        435                 440                 445             


Pro Pro Arg Ile Lys Val Leu Asp Leu His Ser Asn Lys Ile Lys Ser 
    450                 455                 460                 


Val Pro Lys Gln Val Val Lys Leu Glu Ala Leu Gln Glu Leu Asn Val 
465                 470                 475                 480 


Ala Phe Asn Ser Leu Thr Asp Leu Pro Gly Cys Gly Ser Phe Ser Ser 
                485                 490                 495     


Leu Ser Val Leu Ile Ile Asp His Asn Ser Val Ser His Pro Ser Ala 
            500                 505                 510         


Asp Phe Phe Gln Ser Cys Gln Lys Met Arg Ser Ile Lys Ala Gly Asp 
        515                 520                 525             


Asn Pro Phe Gln Cys Thr Cys Glu Leu Arg Glu Phe Val Lys Asn Ile 
    530                 535                 540                 


Asp Gln Val Ser Ser Glu Val Leu Glu Gly Trp Pro Asp Ser Tyr Lys 
545                 550                 555                 560 


Cys Asp Tyr Pro Glu Ser Tyr Arg Gly Ser Pro Leu Lys Asp Phe His 
                565                 570                 575     


Met Ser Glu Leu Ser Cys Asn Ile Thr Leu Leu Ile Val Thr Ile Gly 
            580                 585                 590         


Ala Thr Met Leu Val Leu Ala Val Thr Val Thr Ser Leu Cys Ile Tyr 
        595                 600                 605             


Leu Asp Leu Pro Trp Tyr Leu Arg Met Val Cys Gln Trp Thr Gln Thr 
    610                 615                 620                 


Arg Arg Arg Ala Arg Asn Ile Pro Leu Glu Glu Leu Gln Arg Asn Leu 
625                 630                 635                 640 


Gln Phe His Ala Phe Ile Ser Tyr Ser Glu His Asp Ser Ala Trp Val 
                645                 650                 655     


Lys Ser Glu Leu Val Pro Tyr Leu Glu Lys Glu Asp Ile Gln Ile Cys 
            660                 665                 670         


Leu His Glu Arg Asn Phe Val Pro Gly Lys Ser Ile Val Glu Asn Ile 
        675                 680                 685             


Ile Asn Cys Ile Glu Lys Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro 
    690                 695                 700                 


Asn Phe Val Gln Ser Glu Trp Cys His Tyr Glu Leu Tyr Phe Ala His 
705                 710                 715                 720 


His Asn Leu Phe His Glu Gly Ser Asn Asn Leu Ile Leu Ile Leu Leu 
                725                 730                 735     


Glu Pro Ile Pro Gln Asn Ser Ile Pro Asn Lys Tyr His Lys Leu Lys 
            740                 745                 750         


Ala Leu Met Thr Gln Arg Thr Tyr Leu Gln Trp Pro Lys Glu Lys Ser 
        755                 760                 765             


Lys Arg Gly Leu Phe Trp Ala Asn Ile Arg Ala Ala Phe Asn Met Lys 
    770                 775                 780                 


Leu Thr Leu Val Thr Glu Asn Asn Asp Val Lys Ser 
785                 790                 795     


<210>  3428
<211>  2253
<212>  PRT
<213>  Homo sapiens

<400>  3428

Met Arg Pro Gly Pro Ala Leu Leu Leu Leu Gly Val Gly Leu Ser Leu 
1               5                   10                  15      


Ser Val Gly Arg Leu Pro Leu Pro Pro Val Pro Arg Gly Ala Gln Ala 
            20                  25                  30          


Ala Val Ser Gly Ala Pro Gly Gly Leu Leu Arg Gly Ala Pro Gly Leu 
        35                  40                  45              


Gly Val Arg Gly Gly Arg Ala Leu Leu Ser Leu Arg Pro Ser Ala Val 
    50                  55                  60                  


Arg Ala Gly Gly Ala Val Leu Ser Gly Arg Gly Ser Leu Cys Phe Pro 
65                  70                  75                  80  


His Gly Gly Thr Gly Arg Arg Trp Tyr Cys Leu Asp Leu Arg Val Leu 
                85                  90                  95      


Leu Ser Ala Gln Arg Leu Pro Trp Pro Ala Ala Pro Ala Leu Ala Leu 
            100                 105                 110         


Val Asp Leu Gln Leu Ser Ala Arg Gly Gly Arg Leu Ser Leu Thr Trp 
        115                 120                 125             


Ser Val Arg Leu Pro Arg Ser Pro Gly Arg Leu Ala Trp Ala Phe Arg 
    130                 135                 140                 


Leu Arg Leu Leu Gly Pro Gly Ala Ala Arg Pro Ala Ser Pro Ala Ala 
145                 150                 155                 160 


Arg Val Ser Pro Arg Ser Ala Ala Pro Gly Pro Arg Pro Gln Gln Gly 
                165                 170                 175     


Phe Val Ala Arg Thr Glu Cys Pro Thr Asp Gly Pro Ala Arg Val Met 
            180                 185                 190         


Leu Gln Ala Val Asn Ser Ser Ser His Arg Ala Val Glu Ser Ser Val 
        195                 200                 205             


Ser Cys Gln Ile Asn Ala Cys Val Ile Gln Arg Val Arg Ile Asn Thr 
    210                 215                 220                 


Asp Gln Lys Gly Ala Pro Val Arg Leu Ser Met Gln Ala Glu Ala Thr 
225                 230                 235                 240 


Ile Asn Ala Ser Val Gln Leu Asp Cys Pro Ala Ala Arg Ala Ile Ala 
                245                 250                 255     


Gln Tyr Trp Gln Val Phe Ser Val Pro Ala Val Gly Gln Ala Pro Asp 
            260                 265                 270         


Trp Thr Gln Pro Leu Asp Leu Pro Gln Leu Glu Ile Arg Asn Ser Pro 
        275                 280                 285             


Leu Phe Ile His Ile Pro Asn Asn Ser Leu Gln Trp Gly Val Tyr Val 
    290                 295                 300                 


Phe Asn Phe Thr Val Ser Ile Thr Thr Gly Asn Pro Lys Met Pro Glu 
305                 310                 315                 320 


Val Lys Asp Ser Asp Ala Val Tyr Val Trp Ile Val Arg Ser Ser Leu 
                325                 330                 335     


Gln Ala Val Met Leu Gly Asp Ala Asn Ile Thr Ala Asn Phe Thr Glu 
            340                 345                 350         


Gln Leu Ile Leu Asp Gly Ser Thr Ser Ser Asp Pro Asp Ala Asp Ser 
        355                 360                 365             


Pro Leu Gln Gly Leu Gln Phe Phe Trp Tyr Cys Thr Thr Asp Pro Arg 
    370                 375                 380                 


Asn Tyr Gly Gly Asp Arg Ile Ile Leu Gly Ser Lys Glu Val Cys His 
385                 390                 395                 400 


Pro Glu Gln Ala Asn Leu Lys Trp Pro Trp Ala Ser Gly Pro Val Leu 
                405                 410                 415     


Thr Leu Leu Pro Glu Thr Leu Lys Gly Asp His Val Tyr Phe Phe Arg 
            420                 425                 430         


Met Val Ile Arg Lys Asp Ser Arg Thr Ala Phe Ser Asp Lys Arg Val 
        435                 440                 445             


His Val Leu Gln Gly Pro Lys Ala Ile Ala His Ile Thr Cys Ile Glu 
    450                 455                 460                 


Asn Cys Glu Arg Asn Phe Ile Val Ser Asp Arg Phe Ser Leu Phe Leu 
465                 470                 475                 480 


Asn Cys Thr Asn Cys Ala Ser Arg Asp Phe Tyr Lys Trp Ser Ile Leu 
                485                 490                 495     


Ser Ser Ser Gly Gly Glu Met Leu Phe Asp Trp Met Gly Glu Thr Val 
            500                 505                 510         


Thr Gly Arg Asn Gly Ala Tyr Leu Ser Ile Lys Ala Phe Ala Phe Arg 
        515                 520                 525             


His Phe Leu Glu Ala Glu Phe Ser Ile Ser Leu Tyr Leu Ala Cys Trp 
    530                 535                 540                 


Ser Gly Val Thr Ser Val Phe Arg His Ser Phe Ile Ile Asn His Gly 
545                 550                 555                 560 


Pro Gln Ile Gly Glu Cys Lys Ile Asn Pro Ala Lys Gly Ile Ala Leu 
                565                 570                 575     


Ile Thr Lys Phe Val Val Gln Cys Ser Asn Phe Arg Asp Lys His Val 
            580                 585                 590         


Pro Leu Thr Tyr Lys Ile Ile Val Ser Asp Leu His Ser Val Gly Glu 
        595                 600                 605             


Ile Ser Ser Val Lys Glu Asn Thr Leu Gly Thr Ile Leu Tyr Leu Gly 
    610                 615                 620                 


Pro Gln Ser Thr Val Pro Pro Ser Phe Leu Pro Val Gly Met Leu Ala 
625                 630                 635                 640 


Ser Gln Tyr Gly Leu Lys Ile Tyr Ala Gln Val Tyr Asp Ser Leu Gly 
                645                 650                 655     


Ala Phe Ser Gln Val Thr Leu His Ala Thr Ala Gln Ala Pro Thr Asp 
            660                 665                 670         


Lys Asn Ser Ser Lys Thr Val Leu Asn Gln Leu Leu Ser Phe Thr Val 
        675                 680                 685             


Gly Pro Ser Ser Leu Leu Ser Thr Leu Ile Gln Lys Lys Asp Phe Leu 
    690                 695                 700                 


Pro Ala Gly Tyr Leu Leu Tyr Ile Val Ala Ser Val Leu Asn Asn Met 
705                 710                 715                 720 


Lys Thr Glu Leu Pro Leu Arg Asp Asp Arg Val Asn Leu Arg Lys His 
                725                 730                 735     


Leu Ile Asp Gln Ser Phe Leu Leu Pro Val Ser Thr Leu Val Glu Ile 
            740                 745                 750         


Gly Gln Val Val Met Thr Ile Thr Lys Leu Thr Gln Lys Pro Ser Glu 
        755                 760                 765             


Phe Thr Trp Asp Ala Gln Lys Arg Ala Thr Met Arg Val Trp Gln Ala 
    770                 775                 780                 


Asn Gln Ala Leu Gln Glu Tyr Gln Gln Lys Asp Lys Arg Phe Arg Ser 
785                 790                 795                 800 


Glu Gln Ile Glu Ile Val Ser Thr Gly Ile Leu Met Ser Leu Ser Asn 
                805                 810                 815     


Ile Leu Lys Met Thr Ser Pro His Gln Val Val Lys Asp Pro Phe Tyr 
            820                 825                 830         


Val Ile Glu Ser Leu Ser Asp Thr Ile Leu Ala Asn Lys Val Pro Gly 
        835                 840                 845             


Asn Lys Thr Thr Ser Met Arg Thr Pro Asn Phe Asn Met Tyr Val Lys 
    850                 855                 860                 


Lys Val Glu Lys Trp Gly Ile Asn Gln Leu Phe Arg Asn Glu Lys His 
865                 870                 875                 880 


Cys Arg Asn Cys Phe Tyr Pro Thr Leu Asn Val Ser Ser Val Pro Gly 
                885                 890                 895     


Leu Ser Ala Asn Gly Pro Ile Ser Thr Met Phe Cys Asp Phe Thr Asn 
            900                 905                 910         


Asp Leu Phe Pro Trp Leu Asn Asp Gln Glu Asn Thr Ser Val Glu Val 
        915                 920                 925             


Ser Gly Phe Arg Met Thr Gly Val Ala Asp Asn Gly Ser Val Leu Glu 
    930                 935                 940                 


Ile Thr Pro Asp Val Ala Glu Val Tyr Leu Val Arg Lys Asn Leu Thr 
945                 950                 955                 960 


Phe Ala Ala Phe Asn Leu Thr Val Gly Pro Asn Ser Glu Val Asp Gly 
                965                 970                 975     


Ser Leu Lys Lys Thr Thr Gly Gly Phe Ser Phe Gln Val Asp Ser Thr 
            980                 985                 990         


Val Leu Arg Glu Val Leu Val His  Ile Val Thr Glu Val  Met Val Leu 
        995                 1000                 1005             


Phe Thr  Val Leu Val Tyr Thr  Gly Ser Gln Ile Thr  Pro Thr Ala 
    1010                 1015                 1020             


Leu Val  Ala Thr Phe Leu Val  Pro His Asp Ile Pro  Pro Phe Ala 
    1025                 1030                 1035             


Ser Gln  Ser Ala Leu Phe Asp  Pro Ala Cys Thr Val  Lys Lys Ala 
    1040                 1045                 1050             


Arg Val  Val Cys Leu Pro Val  Ser Leu Leu Gln Leu  Ile Ala Gln 
    1055                 1060                 1065             


His Ser  His Ser Pro His Cys  Thr Val Ser Ile Val  Leu Gln Ala 
    1070                 1075                 1080             


Pro Arg  Phe Val Met Lys Leu  Asn Asp Lys Leu Val  Arg Ile Ser 
    1085                 1090                 1095             


Ile Phe  Ser Val Gln Cys Leu  Asp Met Tyr Gly Ile  Gln Ser Glu 
    1100                 1105                 1110             


Trp Arg  Glu Gly Tyr Cys Ile  Leu Gly Glu Lys Thr  Ser Trp Tyr 
    1115                 1120                 1125             


Glu Val  His Cys Ile Cys Lys  Asn Val Val Arg Ala  Arg Arg Gln 
    1130                 1135                 1140             


Leu Gly  Thr Ile Gly Leu Thr  Gly Ile His Leu His  Thr His Tyr 
    1145                 1150                 1155             


Val Met  Ala Lys Val Ile Val  Ile Pro Asn Pro Val  Asp Leu Arg 
    1160                 1165                 1170             


Leu Asn  Ile Ile Lys Ser Leu  His Gln Asn Pro Val  Thr Leu Phe 
    1175                 1180                 1185             


Thr Val  Leu Phe Ile Ile Leu  Leu Tyr Val Gly Leu  Ala Phe Trp 
    1190                 1195                 1200             


Ala Leu  Tyr Arg Asp Glu Met  Asp Gln His Leu Arg  Gly His Val 
    1205                 1210                 1215             


Ile Val  Leu Pro Asp Asn Asp  Pro Tyr Asp Asn Leu  Cys Tyr Leu 
    1220                 1225                 1230             


Val Thr  Ile Phe Thr Gly Ser  Arg Trp Gly Ser Gly  Thr Arg Ala 
    1235                 1240                 1245             


Asn Val  Phe Val Gln Leu Arg  Gly Thr Val Ser Thr  Ser Asp Val 
    1250                 1255                 1260             


His Cys  Leu Ser His Pro His  Phe Thr Thr Leu Tyr  Arg Gly Ser 
    1265                 1270                 1275             


Ile Asn  Thr Phe Leu Leu Thr  Thr Lys Ser Asp Leu  Gly Asp Ile 
    1280                 1285                 1290             


His Ser  Ile Arg Val Trp His  Asn Asn Glu Gly Arg  Ser Pro Ser 
    1295                 1300                 1305             


Trp Tyr  Leu Ser Arg Ile Lys  Val Glu Asn Leu Phe  Ser Arg His 
    1310                 1315                 1320             


Ile Trp  Leu Phe Ile Cys Gln  Lys Trp Leu Ser Val  Asp Thr Thr 
    1325                 1330                 1335             


Leu Asp  Arg Thr Phe His Val  Thr His Pro Asp Glu  Arg Leu Thr 
    1340                 1345                 1350             


Arg Lys  Asp Phe Phe Phe Ile  Asp Val Ser Ser Asn  Leu Arg Lys 
    1355                 1360                 1365             


Asn His  Met Trp Phe Ser Ile  Phe Ala Ser Val Val  Ala Lys Thr 
    1370                 1375                 1380             


Phe Asn  Arg Leu Gln Arg Leu  Ser Cys Cys Leu Ala  Met Leu Leu 
    1385                 1390                 1395             


Ser Ser  Leu Leu Cys Asn Ile  Met Phe Phe Asn Leu  Asn Arg Gln 
    1400                 1405                 1410             


Glu Gln  Thr Glu Ser Arg Glu  Arg Lys Tyr Met Arg  Ser Met Met 
    1415                 1420                 1425             


Ile Gly  Ile Glu Ser Val Leu  Ile Thr Ile Pro Val  Gln Leu Leu 
    1430                 1435                 1440             


Ile Thr  Phe Leu Phe Thr Cys  Ser Gln Arg Lys Pro  Gln Ala Asp 
    1445                 1450                 1455             


Leu Lys  Glu Val Ser Pro Gln  Lys His Pro Leu Met  Ser Glu Ala 
    1460                 1465                 1470             


Ser Glu  His Trp Glu Glu Tyr  Leu Arg Lys Trp His  Ala Tyr Glu 
    1475                 1480                 1485             


Thr Ala  Lys Val His Pro Arg  Glu Val Ala Lys Pro  Ala Ser Lys 
    1490                 1495                 1500             


Gly Lys  Pro Arg Leu Pro Lys  Ala Ser Pro Lys Ala  Thr Ser Lys 
    1505                 1510                 1515             


Pro Lys  His Arg His Arg Lys  Ala Gln Ile Lys Thr  Pro Glu Thr 
    1520                 1525                 1530             


Leu Gly  Pro Asn Thr Asn Ser  Asn Asn Asn Ile Glu  Asp Asp Gln 
    1535                 1540                 1545             


Asp Val  His Ser Glu Gln His  Pro Ser Gln Lys Asp  Leu Gln Gln 
    1550                 1555                 1560             


Leu Lys  Lys Lys Pro Arg Ile  Val Leu Pro Trp Trp  Cys Val Tyr 
    1565                 1570                 1575             


Val Ala  Trp Phe Leu Val Phe  Ala Thr Ser Ser Ile  Ser Ser Phe 
    1580                 1585                 1590             


Phe Ile  Val Phe Tyr Gly Leu  Thr Tyr Gly Tyr Asp  Lys Ser Ile 
    1595                 1600                 1605             


Glu Trp  Leu Phe Ala Ser Phe  Cys Ser Phe Cys Gln  Ser Val Leu 
    1610                 1615                 1620             


Leu Val  Gln Pro Ser Lys Ile  Ile Leu Leu Ser Gly  Phe Arg Thr 
    1625                 1630                 1635             


Asn Lys  Pro Lys Tyr Cys Lys  Asn Leu Ser Trp Ser  Thr Lys Tyr 
    1640                 1645                 1650             


Lys Tyr  Thr Glu Ile Arg Leu  Asp Gly Met Arg Met  His Pro Glu 
    1655                 1660                 1665             


Glu Met  Gln Arg Ile His Asp  Gln Ile Val Arg Ile  Arg Gly Thr 
    1670                 1675                 1680             


Arg Met  Tyr Gln Pro Leu Thr  Glu Asp Glu Ile Arg  Ile Phe Lys 
    1685                 1690                 1695             


Arg Lys  Lys Arg Ile Lys Arg  Arg Ala Leu Leu Phe  Leu Ser Tyr 
    1700                 1705                 1710             


Ile Leu  Thr His Phe Ile Phe  Leu Ala Leu Leu Leu  Ile Leu Ile 
    1715                 1720                 1725             


Val Leu  Leu Arg His Thr Asp  Cys Phe Tyr Tyr Asn  Gln Phe Ile 
    1730                 1735                 1740             


Arg Asp  Arg Phe Ser Met Asp  Leu Ala Thr Val Thr  Lys Leu Glu 
    1745                 1750                 1755             


Asp Ile  Tyr Arg Trp Leu Asn  Ser Val Leu Leu Pro  Leu Leu His 
    1760                 1765                 1770             


Asn Asp  Leu Asn Pro Thr Phe  Leu Pro Glu Ser Ser  Ser Lys Ile 
    1775                 1780                 1785             


Leu Gly  Leu Pro Leu Met Arg  Gln Val Arg Ala Lys  Ser Ser Glu 
    1790                 1795                 1800             


Lys Met  Cys Leu Pro Ala Glu  Lys Phe Val Gln Asn  Ser Ile Arg 
    1805                 1810                 1815             


Arg Glu  Ile His Cys His Pro  Lys Tyr Gly Ile Asp  Pro Glu Asp 
    1820                 1825                 1830             


Thr Lys  Asn Tyr Ser Gly Phe  Trp Asn Glu Val Asp  Lys Gln Ala 
    1835                 1840                 1845             


Ile Asp  Glu Ser Thr Asn Gly  Phe Thr Tyr Lys Pro  Gln Gly Thr 
    1850                 1855                 1860             


Gln Trp  Leu Tyr Tyr Ser Tyr  Gly Leu Leu His Thr  Tyr Gly Ser 
    1865                 1870                 1875             


Gly Gly  Tyr Ala Leu Tyr Phe  Phe Pro Glu Gln Gln  Arg Phe Asn 
    1880                 1885                 1890             


Ser Thr  Leu Arg Leu Lys Glu  Leu Gln Glu Ser Asn  Trp Leu Asp 
    1895                 1900                 1905             


Glu Lys  Thr Trp Ala Val Val  Leu Glu Leu Thr Thr  Phe Asn Pro 
    1910                 1915                 1920             


Asp Ile  Asn Leu Phe Cys Ser  Ile Ser Val Ile Phe  Glu Val Ser 
    1925                 1930                 1935             


Gln Leu  Gly Val Val Asn Thr  Ser Ile Ser Leu His  Ser Phe Ser 
    1940                 1945                 1950             


Leu Ala  Asp Phe Asp Arg Lys  Ala Ser Ala Glu Ile  Tyr Leu Tyr 
    1955                 1960                 1965             


Val Ala  Ile Leu Ile Phe Phe  Leu Ala Tyr Val Val  Asp Glu Gly 
    1970                 1975                 1980             


Cys Ile  Ile Met Gln Glu Arg  Ala Ser Tyr Val Arg  Ser Val Tyr 
    1985                 1990                 1995             


Asn Leu  Leu Asn Phe Ala Leu  Lys Cys Ile Phe Thr  Val Leu Ile 
    2000                 2005                 2010             


Val Leu  Phe Leu Arg Lys His  Phe Leu Ala Thr Gly  Ile Ile Arg 
    2015                 2020                 2025             


Phe Tyr  Leu Ser Asn Pro Glu  Asp Phe Ile Pro Phe  His Ala Val 
    2030                 2035                 2040             


Ser Gln  Val Asp His Ile Met  Arg Ile Ile Leu Gly  Phe Leu Leu 
    2045                 2050                 2055             


Phe Leu  Thr Ile Leu Lys Thr  Leu Arg Tyr Ser Arg  Phe Phe Tyr 
    2060                 2065                 2070             


Asp Val  Arg Leu Ala Gln Arg  Ala Ile Gln Ala Ala  Leu Pro Gly 
    2075                 2080                 2085             


Ile Cys  His Met Ala Phe Val  Val Ser Val Tyr Phe  Phe Val Tyr 
    2090                 2095                 2100             


Met Ala  Phe Gly Tyr Leu Val  Phe Gly Gln His Glu  Trp Asn Tyr 
    2105                 2110                 2115             


Ser Asn  Leu Ile His Ser Thr  Gln Thr Val Phe Ser  Tyr Cys Val 
    2120                 2125                 2130             


Ser Ala  Phe Gln Asn Thr Glu  Phe Ser Asn Asn Arg  Ile Leu Gly 
    2135                 2140                 2145             


Val Leu  Phe Leu Ser Ser Phe  Met Leu Val Met Ile  Cys Val Leu 
    2150                 2155                 2160             


Ile Asn  Leu Phe Gln Ala Val  Ile Leu Ser Ala Tyr  Glu Glu Met 
    2165                 2170                 2175             


Lys Gln  Pro Val Tyr Glu Glu  Pro Ser Asp Glu Val  Glu Ala Met 
    2180                 2185                 2190             


Thr Tyr  Leu Cys Arg Lys Leu  Arg Thr Met Phe Ser  Phe Leu Thr 
    2195                 2200                 2205             


Ser Gln  Ser Lys Ala Lys Asp  Glu Pro Glu Phe Phe  Ile Asp Met 
    2210                 2215                 2220             


Leu Tyr  Gly Gln Pro Glu Lys  Asn Ser His Arg Tyr  Leu Gly Leu 
    2225                 2230                 2235             


Lys Thr  Arg Asn Ile Asn Gly  Lys Lys Met Val Tyr  Leu Val Val 
    2240                 2245                 2250             


<210>  3429
<211>  729
<212>  PRT
<213>  Homo sapiens

<400>  3429

Met Thr Glu Ile Thr Ala Glu Gly Asn Ala Ser Thr Thr Thr Thr Val 
1               5                   10                  15      


Ile Asp Ser Lys Asn Gly Ser Val Pro Lys Ser Pro Gly Lys Val Leu 
            20                  25                  30          


Lys Arg Thr Val Thr Glu Asp Ile Val Thr Thr Phe Ser Ser Pro Ala 
        35                  40                  45              


Ala Trp Leu Leu Val Ile Ala Leu Ile Ile Thr Trp Ser Ala Val Ala 
    50                  55                  60                  


Ile Val Met Phe Asp Leu Val Asp Tyr Lys Asn Phe Ser Ala Ser Ser 
65                  70                  75                  80  


Ile Ala Lys Ile Gly Ser Asp Pro Leu Lys Leu Val Arg Asp Ala Met 
                85                  90                  95      


Glu Glu Thr Thr Asp Trp Ile Tyr Gly Phe Phe Ser Leu Leu Ser Asp 
            100                 105                 110         


Ile Ile Ser Ser Glu Asp Glu Glu Asp Asp Asp Gly Asp Glu Asp Thr 
        115                 120                 125             


Asp Lys Gly Glu Ile Asp Glu Pro Pro Leu Arg Lys Lys Glu Ile His 
    130                 135                 140                 


Lys Asp Lys Thr Glu Lys Gln Glu Lys Pro Glu Arg Lys Ile Gln Thr 
145                 150                 155                 160 


Lys Val Thr His Lys Glu Lys Glu Lys Gly Lys Glu Lys Val Arg Glu 
                165                 170                 175     


Lys Glu Lys Pro Glu Lys Lys Ala Thr His Lys Glu Lys Ile Glu Lys 
            180                 185                 190         


Lys Glu Lys Pro Glu Thr Lys Thr Leu Ala Lys Glu Gln Lys Lys Ala 
        195                 200                 205             


Lys Thr Ala Glu Lys Ser Glu Glu Lys Thr Lys Lys Glu Val Lys Gly 
    210                 215                 220                 


Gly Lys Gln Glu Lys Val Lys Gln Thr Ala Ala Lys Val Lys Glu Val 
225                 230                 235                 240 


Gln Lys Thr Pro Ser Lys Pro Lys Glu Lys Glu Asp Lys Glu Lys Ala 
                245                 250                 255     


Ala Val Ser Lys His Glu Gln Lys Asp Gln Tyr Ala Phe Cys Arg Tyr 
            260                 265                 270         


Met Ile Asp Ile Phe Val His Gly Asp Leu Lys Pro Gly Gln Ser Pro 
        275                 280                 285             


Ala Ile Pro Pro Pro Leu Pro Thr Glu Gln Ala Ser Arg Pro Thr Pro 
    290                 295                 300                 


Ala Ser Pro Ala Leu Glu Glu Lys Glu Gly Glu Lys Lys Lys Ala Glu 
305                 310                 315                 320 


Lys Lys Val Thr Ser Glu Thr Lys Lys Lys Glu Lys Glu Asp Ile Lys 
                325                 330                 335     


Lys Lys Ser Glu Lys Glu Thr Ala Ile Asp Val Glu Lys Lys Glu Pro 
            340                 345                 350         


Gly Lys Ala Ser Glu Thr Lys Gln Gly Thr Val Lys Ile Ala Ala Gln 
        355                 360                 365             


Ala Ala Ala Lys Lys Asp Glu Lys Lys Glu Asp Ser Lys Lys Thr Lys 
    370                 375                 380                 


Lys Pro Ala Glu Val Glu Gln Pro Lys Gly Lys Lys Gln Glu Lys Lys 
385                 390                 395                 400 


Glu Lys His Val Glu Pro Ala Lys Ser Pro Lys Lys Glu His Ser Val 
                405                 410                 415     


Pro Ser Asp Lys Gln Val Lys Ala Lys Thr Glu Arg Ala Lys Glu Glu 
            420                 425                 430         


Ile Gly Ala Val Ser Ile Lys Lys Ala Val Pro Gly Lys Lys Glu Glu 
        435                 440                 445             


Lys Thr Thr Lys Thr Val Glu Gln Glu Ile Arg Lys Glu Lys Ser Gly 
    450                 455                 460                 


Lys Thr Ser Ser Ile Leu Lys Asp Lys Glu Pro Ile Lys Gly Lys Glu 
465                 470                 475                 480 


Glu Lys Val Pro Ala Ser Leu Lys Glu Lys Glu Pro Glu Thr Lys Lys 
                485                 490                 495     


Asp Glu Lys Met Ser Lys Ala Gly Lys Glu Val Lys Pro Lys Pro Pro 
            500                 505                 510         


Gln Leu Gln Gly Lys Lys Glu Glu Lys Pro Glu Pro Gln Ile Lys Lys 
        515                 520                 525             


Glu Ala Lys Pro Ala Ile Ser Glu Lys Val Gln Ile His Lys Gln Asp 
    530                 535                 540                 


Ile Val Lys Pro Glu Lys Thr Val Ser His Gly Lys Pro Glu Glu Lys 
545                 550                 555                 560 


Val Leu Lys Gln Val Lys Ala Val Thr Ile Glu Lys Thr Ala Lys Pro 
                565                 570                 575     


Lys Pro Thr Lys Lys Ala Glu His Arg Glu Arg Glu Pro Pro Ser Ile 
            580                 585                 590         


Lys Thr Asp Lys Pro Lys Pro Thr Pro Lys Gly Thr Ser Glu Val Thr 
        595                 600                 605             


Glu Ser Gly Lys Lys Lys Thr Glu Ile Ser Glu Lys Glu Ser Lys Glu 
    610                 615                 620                 


Lys Ala Asp Met Lys His Leu Arg Glu Glu Lys Val Ser Thr Arg Lys 
625                 630                 635                 640 


Glu Ser Leu Gln Leu His Asn Val Thr Lys Ala Glu Lys Pro Ala Arg 
                645                 650                 655     


Val Ser Lys Asp Val Glu Asp Val Pro Ala Ser Lys Lys Ala Lys Glu 
            660                 665                 670         


Gly Thr Glu Asp Val Ser Pro Thr Lys Gln Lys Ser Pro Ile Ser Phe 
        675                 680                 685             


Phe Gln Cys Val Tyr Leu Asp Gly Tyr Asn Gly Tyr Gly Phe Gln Phe 
    690                 695                 700                 


Pro Phe Thr Pro Ala Asp Arg Pro Gly Glu Ser Ser Gly Gln Ala Asn 
705                 710                 715                 720 


Ser Pro Gly Gln Lys Gln Gln Gly Gln 
                725                 


<210>  3430
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  3430

Met Gly Leu Phe Asp Arg Gly Val Gln Met Leu Leu Thr Thr Val Gly 
1               5                   10                  15      


Ala Phe Ala Ala Phe Ser Leu Met Thr Ile Ala Val Gly Thr Asp Tyr 
            20                  25                  30          


Trp Leu Tyr Ser Arg Gly Val Cys Lys Thr Lys Ser Val Ser Glu Asn 
        35                  40                  45              


Glu Thr Ser Lys Lys Asn Glu Glu Val Met Thr His Ser Gly Leu Trp 
    50                  55                  60                  


Arg Thr Cys Cys Leu Glu Gly Asn Phe Lys Gly Leu Cys Lys Gln Ile 
65                  70                  75                  80  


Asp His Phe Pro Glu Asp Ala Asp Tyr Glu Ala Asp Thr Ala Glu Tyr 
                85                  90                  95      


Phe Leu Arg Ala Val Arg Ala Ser Ser Ile Phe Pro Ile Leu Ser Val 
            100                 105                 110         


Ile Leu Leu Phe Met Gly Gly Leu Cys Ile Ala Ala Ser Glu Phe Tyr 
        115                 120                 125             


Lys Thr Arg His Asn Ile Ile Leu Ser Ala Gly Ile Phe Phe Val Ser 
    130                 135                 140                 


Ala Gly Leu Ser Asn Ile Ile Gly Ile Ile Val Tyr Ile Ser Ala Asn 
145                 150                 155                 160 


Ala Gly Asp Pro Ser Lys Ser Asp Ser Lys Lys Asn Ser Tyr Ser Tyr 
                165                 170                 175     


Gly Trp Ser Phe Tyr Phe Gly Ala Leu Ser Phe Ile Ile Ala Glu Met 
            180                 185                 190         


Val Gly Val Leu Ala Val His Met Phe Ile Asp Arg His Lys Gln Leu 
        195                 200                 205             


Arg Ala Thr Ala Arg Ala Thr Asp Tyr Leu Gln Ala Ser Ala Ile Thr 
    210                 215                 220                 


Arg Ile Pro Ser Tyr Arg Tyr Arg Tyr Gln Arg Arg Ser Arg Ser Ser 
225                 230                 235                 240 


Ser Arg Ser Thr Glu Pro Ser His Ser Arg Asp Ala Ser Pro Val Gly 
                245                 250                 255     


Ile Lys Gly Phe Asn Thr Leu Pro Ser Thr Glu Ile Ser Met Tyr Thr 
            260                 265                 270         


Leu Ser Arg Asp Pro Leu Lys Ala Ala Thr Thr Pro Thr Ala Thr Tyr 
        275                 280                 285             


Asn Ser Asp Arg Asp Asn Ser Phe Leu Gln Val His Asn Cys Ile Gln 
    290                 295                 300                 


Lys Glu Asn Lys Asp Ser Leu His Ser Asn Thr Ala Asn Arg Arg Thr 
305                 310                 315                 320 


Thr Pro Val 
            


<210>  3431
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  3431

Met Arg Glu Ile Val His Ile Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Ser Gly Asn Tyr Val Gly Asp Ser Asp Leu Gln Leu Glu Arg Ile Ser 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ala Ser Ser His Lys Tyr Val Pro Arg Ala Ile 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Ala 
65                  70                  75                  80  


Phe Gly His Leu Phe Arg Pro Asp Asn Phe Ile Phe Gly Gln Ser Gly 
                85                  90                  95      


Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         


Val Asp Ser Val Leu Asp Val Val Arg Lys Glu Cys Glu Asn Cys Asp 
        115                 120                 125             


Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Val Arg Glu Glu Tyr Pro 
145                 150                 155                 160 


Asp Arg Ile Met Asn Thr Phe Ser Val Val Pro Ser Pro Lys Val Ser 
                165                 170                 175     


Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Ile His Gln Leu 
            180                 185                 190         


Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr 
        195                 200                 205             


Asp Ile Cys Phe Arg Thr Leu Lys Leu Ala Thr Pro Thr Tyr Gly Asp 
    210                 215                 220                 


Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Ser Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                245                 250                 255     


Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
            260                 265                 270         


Leu Thr Ala Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 
        275                 280                 285             


Leu Thr Gln Gln Met Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp 
    290                 295                 300                 


Pro Arg His Gly Arg Tyr Leu Thr Val Ala Thr Val Phe Arg Gly Arg 
305                 310                 315                 320 


Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Ala Ile Gln Ser Lys 
                325                 330                 335     


Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Val Ala 
            340                 345                 350         


Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ser Ser Thr Phe Ile 
        355                 360                 365             


Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
    370                 375                 380                 


Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 
385                 390                 395                 400 


Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                405                 410                 415     


Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Glu 
            420                 425                 430         


Glu Gly Glu Met Tyr Glu Asp Asp Glu Glu Glu Ser Glu Ala Gln Gly 
        435                 440                 445             


Pro Lys 
    450 


<210>  3432
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  3432

Met Ser Gly His Arg Ser Thr Arg Lys Arg Cys Gly Asp Ser His Pro 
1               5                   10                  15      


Glu Ser Pro Val Gly Phe Gly His Met Ser Thr Thr Gly Cys Val Leu 
            20                  25                  30          


Asn Lys Leu Phe Gln Leu Pro Thr Pro Pro Leu Ser Arg His Gln Leu 
        35                  40                  45              


Lys Arg Leu Glu Glu His Arg Tyr Gln Ser Ala Gly Arg Ser Leu Leu 
    50                  55                  60                  


Glu Pro Leu Met Gln Gly Tyr Trp Glu Trp Leu Val Arg Arg Val Pro 
65                  70                  75                  80  


Ser Trp Ile Ala Pro Asn Leu Ile Thr Ile Ile Gly Leu Ser Ile Asn 
                85                  90                  95      


Ile Cys Thr Thr Ile Leu Leu Val Phe Tyr Cys Pro Thr Ala Thr Glu 
            100                 105                 110         


Gln Ala Pro Leu Trp Ala Tyr Ile Ala Cys Ala Cys Gly Leu Phe Ile 
        115                 120                 125             


Tyr Gln Ser Leu Asp Ala Ile Asp Gly Lys Gln Ala Arg Arg Thr Asn 
    130                 135                 140                 


Ser Ser Ser Pro Leu Gly Glu Leu Phe Asp His Gly Cys Asp Ser Leu 
145                 150                 155                 160 


Ser Thr Val Phe Val Val Leu Gly Thr Cys Ile Ala Val Gln Leu Gly 
                165                 170                 175     


Thr Asn Pro Asp Trp Met Phe Phe Cys Cys Phe Ala Gly Thr Phe Met 
            180                 185                 190         


Phe Tyr Cys Ala His Trp Gln Thr Tyr Val Ser Gly Thr Leu Arg Phe 
        195                 200                 205             


Gly Ile Ile Asp Val Thr Glu Val Gln Ile Phe Ile Ile Ile Met His 
    210                 215                 220                 


Leu Leu Ala Val Ile Gly Gly Pro Pro Phe Trp Gln Ser Met Ile Pro 
225                 230                 235                 240 


Val Leu Asn Ile Gln Met Lys Ile Phe Pro Ala Leu Cys Thr Val Ala 
                245                 250                 255     


Gly Thr Ile Phe Ser Cys Thr Asn Tyr Phe Arg Val Ile Phe Thr Gly 
            260                 265                 270         


Gly Val Gly Lys Asn Gly Ser Thr Ile Ala Gly Thr Ser Val Leu Ser 
        275                 280                 285             


Pro Phe Leu His Ile Gly Ser Val Ile Thr Leu Ala Ala Met Ile Tyr 
    290                 295                 300                 


Lys Lys Ser Ala Val Gln Leu Phe Glu Lys His Pro Cys Leu Tyr Ile 
305                 310                 315                 320 


Leu Thr Phe Gly Phe Val Ser Ala Lys Ile Thr Asn Lys Leu Val Val 
                325                 330                 335     


Ala His Met Thr Lys Ser Glu Met His Leu His Asp Thr Ala Phe Ile 
            340                 345                 350         


Gly Pro Ala Leu Leu Phe Leu Asp Gln Tyr Phe Asn Ser Phe Ile Asp 
        355                 360                 365             


Glu Tyr Ile Val Leu Trp Ile Ala Leu Val Phe Ser Phe Phe Asp Leu 
    370                 375                 380                 


Ile Arg Tyr Cys Val Ser Val Cys Asn Gln Ile Ala Ser His Leu His 
385                 390                 395                 400 


Ile His Val Phe Arg Ile Lys Val Ser Thr Ala His Ser Asn His His 
                405                 410                 415     


<210>  3433
<211>  1164
<212>  PRT
<213>  Homo sapiens

<400>  3433

Met Pro Thr Met Arg Arg Thr Val Ser Glu Ile Arg Ser Arg Ala Glu 
1               5                   10                  15      


Gly Tyr Glu Lys Thr Asp Asp Val Ser Glu Lys Thr Ser Leu Ala Asp 
            20                  25                  30          


Gln Glu Glu Val Arg Thr Ile Phe Ile Asn Gln Pro Gln Leu Thr Lys 
        35                  40                  45              


Phe Cys Asn Asn His Val Ser Thr Ala Lys Tyr Asn Ile Ile Thr Phe 
    50                  55                  60                  


Leu Pro Arg Phe Leu Tyr Ser Gln Phe Arg Arg Ala Ala Asn Ser Phe 
65                  70                  75                  80  


Phe Leu Phe Ile Ala Leu Leu Gln Gln Ile Pro Asp Val Ser Pro Thr 
                85                  90                  95      


Gly Arg Tyr Thr Thr Leu Val Pro Leu Leu Phe Ile Leu Ala Val Ala 
            100                 105                 110         


Ala Ile Lys Glu Ile Ile Glu Asp Ile Lys Arg His Lys Ala Asp Asn 
        115                 120                 125             


Ala Val Asn Lys Lys Gln Thr Gln Val Leu Arg Asn Gly Ala Trp Glu 
    130                 135                 140                 


Ile Val His Trp Glu Lys Val Ala Val Gly Glu Ile Val Lys Val Thr 
145                 150                 155                 160 


Asn Gly Glu His Leu Pro Ala Asp Leu Ile Ser Leu Ser Ser Ser Glu 
                165                 170                 175     


Pro Gln Ala Met Cys Tyr Ile Glu Thr Ser Asn Leu Asp Gly Glu Thr 
            180                 185                 190         


Asn Leu Lys Ile Arg Gln Gly Leu Pro Ala Thr Ser Asp Ile Lys Asp 
        195                 200                 205             


Val Asp Ser Leu Met Arg Ile Ser Gly Arg Ile Glu Cys Glu Ser Pro 
    210                 215                 220                 


Asn Arg His Leu Tyr Asp Phe Val Gly Asn Ile Arg Leu Asp Gly His 
225                 230                 235                 240 


Gly Thr Val Pro Leu Gly Ala Asp Gln Ile Leu Leu Arg Gly Ala Gln 
                245                 250                 255     


Leu Arg Asn Thr Gln Trp Val His Gly Ile Val Val Tyr Thr Gly His 
            260                 265                 270         


Asp Thr Lys Leu Met Gln Asn Ser Thr Ser Pro Pro Leu Lys Leu Ser 
        275                 280                 285             


Asn Val Glu Arg Ile Thr Asn Val Gln Ile Leu Ile Leu Phe Cys Ile 
    290                 295                 300                 


Leu Ile Ala Met Ser Leu Val Cys Ser Val Gly Ser Ala Ile Trp Asn 
305                 310                 315                 320 


Arg Arg His Ser Gly Lys Asp Trp Tyr Leu Asn Leu Asn Tyr Gly Gly 
                325                 330                 335     


Ala Ser Asn Phe Gly Leu Asn Phe Leu Thr Phe Ile Ile Leu Phe Asn 
            340                 345                 350         


Asn Leu Ile Pro Ile Ser Leu Leu Val Thr Leu Glu Val Val Lys Phe 
        355                 360                 365             


Thr Gln Ala Tyr Phe Ile Asn Trp Asp Leu Asp Met His Tyr Glu Pro 
    370                 375                 380                 


Thr Asp Thr Ala Ala Met Ala Arg Thr Ser Asn Leu Asn Glu Glu Leu 
385                 390                 395                 400 


Gly Gln Val Lys Tyr Ile Phe Ser Asp Lys Thr Gly Thr Leu Thr Cys 
                405                 410                 415     


Asn Val Met Gln Phe Lys Lys Cys Thr Ile Ala Gly Val Ala Tyr Gly 
            420                 425                 430         


His Val Pro Glu Pro Glu Asp Tyr Gly Cys Ser Pro Asp Glu Trp Gln 
        435                 440                 445             


Asn Ser Gln Phe Gly Asp Glu Lys Thr Phe Ser Asp Ser Ser Leu Leu 
    450                 455                 460                 


Glu Asn Leu Gln Asn Asn His Pro Thr Ala Pro Ile Ile Cys Glu Phe 
465                 470                 475                 480 


Leu Thr Met Met Ala Val Cys His Thr Ala Val Pro Glu Arg Glu Gly 
                485                 490                 495     


Asp Lys Ile Ile Tyr Gln Ala Ala Ser Pro Asp Glu Gly Ala Leu Val 
            500                 505                 510         


Arg Ala Ala Lys Gln Leu Asn Phe Val Phe Thr Gly Arg Thr Pro Asp 
        515                 520                 525             


Ser Val Ile Ile Asp Ser Leu Gly Gln Glu Glu Arg Tyr Glu Leu Leu 
    530                 535                 540                 


Asn Val Leu Glu Phe Thr Ser Ala Arg Lys Arg Met Ser Val Ile Val 
545                 550                 555                 560 


Arg Thr Pro Ser Gly Lys Leu Arg Leu Tyr Cys Lys Gly Ala Asp Thr 
                565                 570                 575     


Val Ile Tyr Asp Arg Leu Ala Glu Thr Ser Lys Tyr Lys Glu Ile Thr 
            580                 585                 590         


Leu Lys His Leu Glu Gln Phe Ala Thr Glu Gly Leu Arg Thr Leu Cys 
        595                 600                 605             


Phe Ala Val Ala Glu Ile Ser Glu Ser Asp Phe Gln Glu Trp Arg Ala 
    610                 615                 620                 


Val Tyr Gln Arg Ala Ser Thr Ser Val Gln Asn Arg Leu Leu Lys Leu 
625                 630                 635                 640 


Glu Glu Ser Tyr Glu Leu Ile Glu Lys Asn Leu Gln Leu Leu Gly Ala 
                645                 650                 655     


Thr Ala Ile Glu Asp Lys Leu Gln Asp Gln Val Pro Glu Thr Ile Glu 
            660                 665                 670         


Thr Leu Met Lys Ala Asp Ile Lys Ile Trp Ile Leu Thr Gly Asp Lys 
        675                 680                 685             


Gln Glu Thr Ala Ile Asn Ile Gly His Ser Cys Lys Leu Leu Lys Lys 
    690                 695                 700                 


Asn Met Gly Met Ile Val Ile Asn Glu Gly Ser Leu Asp Gly Thr Arg 
705                 710                 715                 720 


Glu Thr Leu Ser Arg His Cys Thr Thr Leu Gly Asp Ala Leu Arg Lys 
                725                 730                 735     


Glu Asn Asp Phe Ala Leu Ile Ile Asp Gly Lys Thr Leu Lys Tyr Ala 
            740                 745                 750         


Leu Thr Phe Gly Val Arg Gln Tyr Phe Leu Asp Leu Ala Leu Ser Cys 
        755                 760                 765             


Lys Ala Val Ile Cys Cys Arg Val Ser Pro Leu Gln Lys Ser Glu Val 
    770                 775                 780                 


Val Glu Met Val Lys Lys Gln Val Lys Val Val Thr Leu Ala Ile Gly 
785                 790                 795                 800 


Asp Gly Ala Asn Asp Val Ser Met Ile Gln Thr Ala His Val Gly Val 
                805                 810                 815     


Gly Ile Ser Gly Asn Glu Gly Leu Gln Ala Ala Asn Ser Ser Asp Tyr 
            820                 825                 830         


Ser Ile Ala Gln Phe Lys Tyr Leu Lys Asn Leu Leu Met Ile His Gly 
        835                 840                 845             


Ala Trp Asn Tyr Asn Arg Val Ser Lys Cys Ile Leu Tyr Cys Phe Tyr 
    850                 855                 860                 


Lys Asn Ile Val Leu Tyr Ile Ile Glu Ile Trp Phe Ala Phe Val Asn 
865                 870                 875                 880 


Gly Phe Ser Gly Gln Ile Leu Phe Glu Arg Trp Cys Ile Gly Leu Tyr 
                885                 890                 895     


Asn Val Met Phe Thr Ala Met Pro Pro Leu Thr Leu Gly Ile Phe Glu 
            900                 905                 910         


Arg Ser Cys Arg Lys Glu Asn Met Leu Lys Tyr Pro Glu Leu Tyr Lys 
        915                 920                 925             


Thr Ser Gln Asn Ala Leu Asp Phe Asn Thr Lys Val Phe Trp Val His 
    930                 935                 940                 


Cys Leu Asn Gly Leu Phe His Ser Val Ile Leu Phe Trp Phe Pro Leu 
945                 950                 955                 960 


Lys Ala Leu Gln Tyr Gly Thr Ala Phe Gly Asn Gly Lys Thr Ser Asp 
                965                 970                 975     


Tyr Leu Leu Leu Gly Asn Phe Val Tyr Thr Phe Val Val Ile Thr Val 
            980                 985                 990         


Cys Leu Lys Ala Gly Leu Glu Thr  Ser Tyr Trp Thr Trp  Phe Ser His 
        995                 1000                 1005             


Ile Ala  Ile Trp Gly Ser Ile  Ala Leu Trp Val Val  Phe Phe Gly 
    1010                 1015                 1020             


Ile Tyr  Ser Ser Leu Trp Pro  Ala Ile Pro Met Ala  Pro Asp Met 
    1025                 1030                 1035             


Ser Gly  Glu Ala Ala Met Leu  Phe Ser Ser Gly Val  Phe Trp Met 
    1040                 1045                 1050             


Gly Leu  Leu Phe Ile Pro Val  Ala Ser Leu Leu Leu  Asp Val Val 
    1055                 1060                 1065             


Tyr Lys  Val Ile Lys Arg Thr  Ala Phe Lys Thr Leu  Val Asp Glu 
    1070                 1075                 1080             


Val Gln  Glu Leu Glu Ala Lys  Ser Gln Asp Pro Gly  Ala Val Val 
    1085                 1090                 1095             


Leu Gly  Lys Ser Leu Thr Glu  Arg Ala Gln Leu Leu  Lys Asn Val 
    1100                 1105                 1110             


Phe Lys  Lys Asn His Val Asn  Leu Tyr Arg Ser Glu  Ser Leu Gln 
    1115                 1120                 1125             


Gln Asn  Leu Leu His Gly Tyr  Ala Phe Ser Gln Asp  Glu Asn Gly 
    1130                 1135                 1140             


Ile Val  Ser Gln Ser Glu Val  Ile Arg Ala Tyr Asp  Thr Thr Lys 
    1145                 1150                 1155             


Gln Arg  Pro Asp Glu Trp 
    1160                 


<210>  3434
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  3434

Met Ser Arg Glu Met Gln Asp Val Asp Leu Ala Glu Val Lys Pro Leu 
1               5                   10                  15      


Val Glu Lys Gly Glu Thr Ile Thr Gly Leu Leu Gln Glu Phe Asp Val 
            20                  25                  30          


Gln Glu Gln Asp Ile Glu Thr Leu His Gly Ser Val His Val Thr Leu 
        35                  40                  45              


Cys Gly Thr Pro Lys Gly Asn Arg Pro Val Ile Leu Thr Tyr His Asp 
    50                  55                  60                  


Ile Gly Met Asn His Lys Thr Cys Tyr Asn Pro Leu Phe Asn Tyr Glu 
65                  70                  75                  80  


Asp Met Gln Glu Ile Thr Gln His Phe Ala Val Cys His Val Asp Ala 
                85                  90                  95      


Pro Gly Gln Gln Asp Gly Ala Ala Ser Phe Pro Ala Gly Tyr Met Tyr 
            100                 105                 110         


Pro Ser Met Asp Gln Leu Ala Glu Met Leu Pro Gly Val Leu Gln Gln 
        115                 120                 125             


Phe Gly Leu Lys Ser Ile Ile Gly Met Gly Thr Gly Ala Gly Ala Tyr 
    130                 135                 140                 


Ile Leu Thr Arg Phe Ala Leu Asn Asn Pro Glu Met Val Glu Gly Leu 
145                 150                 155                 160 


Val Leu Ile Asn Val Asn Pro Cys Ala Glu Gly Trp Met Asp Trp Ala 
                165                 170                 175     


Ala Ser Lys Ile Ser Gly Trp Thr Gln Ala Leu Pro Asp Met Val Val 
            180                 185                 190         


Ser His Leu Phe Gly Lys Glu Glu Met Gln Ser Asn Val Glu Val Val 
        195                 200                 205             


His Thr Tyr Arg Gln His Ile Val Asn Asp Met Asn Pro Gly Asn Leu 
    210                 215                 220                 


His Leu Phe Ile Asn Ala Tyr Asn Ser Arg Arg Asp Leu Glu Ile Glu 
225                 230                 235                 240 


Arg Pro Met Pro Gly Thr His Thr Val Thr Leu Gln Cys Pro Ala Leu 
                245                 250                 255     


Leu Val Val Gly Asp Ser Ser Pro Ala Val Asp Ala Val Val Glu Cys 
            260                 265                 270         


Asn Ser Lys Leu Asp Pro Thr Lys Thr Thr Leu Leu Lys Met Ala Asp 
        275                 280                 285             


Cys Gly Gly Leu Pro Gln Ile Ser Gln Pro Ala Lys Leu Ala Glu Ala 
    290                 295                 300                 


Phe Lys Tyr Phe Val Gln Gly Met Gly Tyr Met Pro Ser Ala Ser Met 
305                 310                 315                 320 


Thr Arg Leu Met Arg Ser Arg Thr Ala Ser Gly Ser Ser Val Thr Ser 
                325                 330                 335     


Leu Asp Gly Thr Arg Ser Arg Ser His Thr Ser Glu Gly Thr Arg Ser 
            340                 345                 350         


Arg Ser His Thr Ser Glu Gly Thr Arg Ser Arg Ser His Thr Ser Glu 
        355                 360                 365             


Gly Ala His Leu Asp Ile Thr Pro Asn Ser Gly Ala Ala Gly Asn Ser 
    370                 375                 380                 


Ala Gly Pro Lys Ser Met Glu Val Ser Cys 
385                 390                 


<210>  3435
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  3435

Met Arg Gly Tyr Leu Val Ala Ile Phe Leu Ser Ala Val Phe Leu Tyr 
1               5                   10                  15      


Tyr Val Leu His Cys Ile Leu Trp Gly Thr Asn Val Tyr Trp Val Ala 
            20                  25                  30          


Pro Val Glu Met Lys Arg Arg Asn Lys Ile Gln Pro Cys Leu Ser Lys 
        35                  40                  45              


Pro Ala Phe Ala Ser Leu Leu Arg Phe His Gln Phe His Pro Phe Leu 
    50                  55                  60                  


Cys Ala Ala Asp Phe Arg Lys Ile Ala Ser Leu Tyr Gly Ser Asp Lys 
65                  70                  75                  80  


Phe Asp Leu Pro Tyr Gly Met Arg Thr Ser Ala Glu Tyr Phe Arg Leu 
                85                  90                  95      


Ala Leu Ser Lys Leu Gln Ser Cys Asp Leu Phe Asp Glu Phe Asp Asn 
            100                 105                 110         


Ile Pro Cys Lys Lys Cys Val Val Val Gly Asn Gly Gly Val Leu Lys 
        115                 120                 125             


Asn Lys Thr Leu Gly Glu Lys Ile Asp Ser Tyr Asp Val Ile Ile Arg 
    130                 135                 140                 


Met Asn Asn Gly Pro Val Leu Gly His Glu Glu Glu Val Gly Arg Arg 
145                 150                 155                 160 


Thr Thr Phe Arg Leu Phe Tyr Pro Glu Ser Val Phe Ser Asp Pro Ile 
                165                 170                 175     


His Asn Asp Pro Asn Thr Thr Val Ile Leu Thr Ala Phe Lys Pro His 
            180                 185                 190         


Asp Leu Arg Trp Leu Leu Glu Leu Leu Met Gly Asp Lys Ile Asn Thr 
        195                 200                 205             


Asn Gly Phe Trp Lys Lys Pro Ala Leu Asn Leu Ile Tyr Lys Pro Tyr 
    210                 215                 220                 


Gln Ile Arg Ile Leu Asp Pro Phe Ile Ile Arg Thr Ala Ala Tyr Glu 
225                 230                 235                 240 


Leu Leu His Phe Pro Lys Val Phe Pro Lys Asn Gln Lys Pro Lys His 
                245                 250                 255     


Pro Thr Thr Gly Ile Ile Ala Ile Thr Leu Ala Phe Tyr Ile Cys His 
            260                 265                 270         


Glu Val His Leu Ala Gly Phe Lys Tyr Asn Phe Ser Asp Leu Lys Ser 
        275                 280                 285             


Pro Leu His Tyr Tyr Gly Asn Ala Thr Met Ser Leu Met Asn Lys Asn 
    290                 295                 300                 


Ala Tyr His Asn Val Thr Ala Glu Gln Leu Phe Leu Lys Asp Ile Ile 
305                 310                 315                 320 


Glu Lys Asn Leu Val Ile Asn Leu Thr Gln Asp 
                325                 330     


<210>  3436
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  3436

Met Pro Ala Cys Arg Leu Gly Pro Leu Ala Ala Ala Leu Leu Leu Ser 
1               5                   10                  15      


Leu Leu Leu Phe Gly Phe Thr Leu Val Ser Gly Thr Gly Ala Glu Lys 
            20                  25                  30          


Thr Gly Val Cys Pro Glu Leu Gln Ala Asp Gln Asn Cys Thr Gln Glu 
        35                  40                  45              


Cys Val Ser Asp Ser Glu Cys Ala Asp Asn Leu Lys Cys Cys Ser Ala 
    50                  55                  60                  


Gly Cys Ala Thr Phe Cys Ser Leu Pro Asn Asp Lys Glu Gly Ser Cys 
65                  70                  75                  80  


Pro Gln Val Asn Ile Asn Phe Pro Gln Leu Gly Leu Cys Arg Asp Gln 
                85                  90                  95      


Cys Gln Val Asp Ser Gln Cys Pro Gly Gln Met Lys Cys Cys Arg Asn 
            100                 105                 110         


Gly Cys Gly Lys Val Ser Cys Val Thr Pro Asn Phe 
        115                 120                 


<210>  3437
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  3437

Met Gly His Glu Gln Asn Gln Gly Ala Ala Leu Leu Gln Met Leu Pro 
1               5                   10                  15      


Leu Leu Trp Leu Leu Pro His Ser Trp Ala Val Pro Glu Ala Pro Thr 
            20                  25                  30          


Pro Met Trp Pro Asp Asp Leu Gln Asn His Thr Phe Leu His Thr Val 
        35                  40                  45              


Tyr Cys Gln Asp Gly Ser Pro Ser Val Gly Leu Ser Glu Ala Tyr Asp 
    50                  55                  60                  


Glu Asp Gln Leu Phe Phe Phe Asp Phe Ser Gln Asn Thr Arg Val Pro 
65                  70                  75                  80  


Arg Leu Pro Glu Phe Ala Asp Trp Ala Gln Glu Gln Gly Asp Ala Pro 
                85                  90                  95      


Ala Ile Leu Phe Asp Lys Glu Phe Cys Glu Trp Met Ile Gln Gln Ile 
            100                 105                 110         


Gly Pro Lys Leu Asp Gly Lys Ile Pro Val Ser Arg Gly Phe Pro Ile 
        115                 120                 125             


Ala Glu Val Phe Thr Leu Lys Pro Leu Glu Phe Gly Lys Pro Asn Thr 
    130                 135                 140                 


Leu Val Cys Phe Val Ser Asn Leu Phe Pro Pro Met Leu Thr Val Asn 
145                 150                 155                 160 


Trp Gln His His Ser Val Pro Val Glu Gly Phe Gly Pro Thr Phe Val 
                165                 170                 175     


Ser Ala Val Asp Gly Leu Ser Phe Gln Ala Phe Ser Tyr Leu Asn Phe 
            180                 185                 190         


Thr Pro Glu Pro Ser Asp Ile Phe Ser Cys Ile Val Thr His Glu Ile 
        195                 200                 205             


Asp Arg Tyr Thr Ala Ile Ala Tyr Trp Val Pro Arg Asn Ala Leu Pro 
    210                 215                 220                 


Ser Asp Leu Leu Glu Asn Val Leu Cys Gly Val Ala Phe Gly Leu Gly 
225                 230                 235                 240 


Val Leu Gly Ile Ile Val Gly Ile Val Leu Ile Ile Tyr Phe Arg Lys 
                245                 250                 255     


Pro Cys Ser Gly Asp 
            260     


<210>  3438
<211>  1150
<212>  PRT
<213>  Homo sapiens

<400>  3438

Met Lys Leu Lys Lys Gln Val Thr Val Cys Gly Ala Ala Ile Phe Cys 
1               5                   10                  15      


Val Ala Val Phe Ser Leu Tyr Leu Met Leu Asp Arg Val Gln His Asp 
            20                  25                  30          


Pro Thr Arg His Gln Asn Gly Gly Asn Phe Pro Arg Ser Gln Ile Ser 
        35                  40                  45              


Val Leu Gln Asn Arg Ile Glu Gln Leu Glu Gln Leu Leu Glu Glu Asn 
    50                  55                  60                  


His Glu Ile Ile Ser His Ile Lys Asp Ser Val Leu Glu Leu Thr Ala 
65                  70                  75                  80  


Asn Ala Glu Gly Pro Pro Ala Met Leu Pro Tyr Tyr Thr Val Asn Gly 
                85                  90                  95      


Ser Trp Val Val Pro Pro Glu Pro Arg Pro Ser Phe Phe Ser Ile Ser 
            100                 105                 110         


Pro Gln Asp Cys Gln Phe Ala Leu Gly Gly Arg Gly Gln Lys Pro Glu 
        115                 120                 125             


Leu Gln Met Leu Thr Val Ser Glu Glu Leu Pro Phe Asp Asn Val Asp 
    130                 135                 140                 


Gly Gly Val Trp Arg Gln Gly Phe Asp Ile Ser Tyr Asp Pro His Asp 
145                 150                 155                 160 


Trp Asp Ala Glu Asp Leu Gln Val Phe Val Val Pro His Ser His Asn 
                165                 170                 175     


Asp Pro Gly Trp Ile Lys Thr Phe Asp Lys Tyr Tyr Thr Glu Gln Thr 
            180                 185                 190         


Gln His Ile Leu Asn Ser Met Val Ser Lys Leu Gln Glu Asp Pro Arg 
        195                 200                 205             


Arg Arg Phe Leu Trp Ala Glu Val Ser Phe Phe Ala Lys Trp Trp Asp 
    210                 215                 220                 


Asn Ile Asn Val Gln Lys Arg Ala Ala Val Arg Arg Leu Val Gly Asn 
225                 230                 235                 240 


Gly Gln Leu Glu Ile Ala Thr Gly Gly Trp Val Met Pro Asp Glu Ala 
                245                 250                 255     


Asn Ser His Tyr Phe Ala Leu Ile Asp Gln Leu Ile Glu Gly His Gln 
            260                 265                 270         


Trp Leu Glu Arg Asn Leu Gly Ala Thr Pro Arg Ser Gly Trp Ala Val 
        275                 280                 285             


Asp Pro Phe Gly Tyr Ser Ser Thr Met Pro Tyr Leu Leu Arg Arg Ala 
    290                 295                 300                 


Asn Leu Thr Ser Met Leu Ile Gln Arg Val His Tyr Ala Ile Lys Lys 
305                 310                 315                 320 


His Phe Ala Ala Thr His Ser Leu Glu Phe Met Trp Arg Gln Thr Trp 
                325                 330                 335     


Asp Ser Asp Ser Ser Thr Asp Ile Phe Cys His Met Met Pro Phe Tyr 
            340                 345                 350         


Ser Tyr Asp Val Pro His Thr Cys Gly Pro Asp Pro Lys Ile Cys Cys 
        355                 360                 365             


Gln Phe Asp Phe Lys Arg Leu Pro Gly Gly Arg Ile Asn Cys Pro Trp 
    370                 375                 380                 


Lys Val Pro Pro Arg Ala Ile Thr Glu Ala Asn Val Ala Glu Arg Ala 
385                 390                 395                 400 


Ala Leu Leu Leu Asp Gln Tyr Arg Lys Lys Ser Gln Leu Phe Arg Ser 
                405                 410                 415     


Asn Val Leu Leu Val Pro Leu Gly Asp Asp Phe Arg Tyr Asp Lys Pro 
            420                 425                 430         


Gln Glu Trp Asp Ala Gln Phe Phe Asn Tyr Gln Arg Leu Phe Asp Phe 
        435                 440                 445             


Phe Asn Ser Arg Pro Asn Leu His Val Gln Ala Gln Phe Gly Thr Leu 
    450                 455                 460                 


Ser Asp Tyr Phe Asp Ala Leu Tyr Lys Arg Thr Gly Val Glu Pro Gly 
465                 470                 475                 480 


Ala Arg Pro Pro Gly Phe Pro Val Leu Ser Gly Asp Phe Phe Ser Tyr 
                485                 490                 495     


Ala Asp Arg Glu Asp His Tyr Trp Thr Gly Tyr Tyr Thr Ser Arg Pro 
            500                 505                 510         


Phe Tyr Lys Ser Leu Asp Arg Val Leu Glu Ala His Leu Arg Gly Ala 
        515                 520                 525             


Glu Val Leu Tyr Ser Leu Ala Ala Ala His Ala Arg Arg Ser Gly Leu 
    530                 535                 540                 


Ala Gly Arg Tyr Pro Leu Ser Asp Phe Thr Leu Leu Thr Glu Ala Arg 
545                 550                 555                 560 


Arg Thr Leu Gly Leu Phe Gln His His Asp Ala Ile Thr Gly Thr Ala 
                565                 570                 575     


Lys Glu Ala Val Val Val Asp Tyr Gly Val Arg Leu Leu Arg Ser Leu 
            580                 585                 590         


Val Asn Leu Lys Gln Val Ile Ile His Ala Ala His Tyr Leu Val Leu 
        595                 600                 605             


Gly Asp Lys Glu Thr Tyr His Phe Asp Pro Glu Ala Pro Phe Leu Gln 
    610                 615                 620                 


Val Asp Asp Thr Arg Leu Ser His Asp Ala Leu Pro Glu Arg Thr Val 
625                 630                 635                 640 


Ile Gln Leu Asp Ser Ser Pro Arg Phe Val Val Leu Phe Asn Pro Leu 
                645                 650                 655     


Glu Gln Glu Arg Phe Ser Met Val Ser Leu Leu Val Asn Ser Pro Arg 
            660                 665                 670         


Val Arg Val Leu Ser Glu Glu Gly Gln Pro Leu Ala Val Gln Ile Ser 
        675                 680                 685             


Ala His Trp Ser Ser Ala Thr Glu Ala Val Pro Asp Val Tyr Gln Val 
    690                 695                 700                 


Ser Val Pro Val Arg Leu Pro Ala Leu Gly Leu Gly Val Leu Gln Leu 
705                 710                 715                 720 


Gln Leu Gly Leu Asp Gly His Arg Thr Leu Pro Ser Ser Val Arg Ile 
                725                 730                 735     


Tyr Leu His Gly Arg Gln Leu Ser Val Ser Arg His Glu Ala Phe Pro 
            740                 745                 750         


Leu Arg Val Ile Asp Ser Gly Thr Ser Asp Phe Ala Leu Ser Asn Arg 
        755                 760                 765             


Tyr Met Gln Val Trp Phe Ser Gly Leu Thr Gly Leu Leu Lys Ser Ile 
    770                 775                 780                 


Arg Arg Val Asp Glu Glu His Glu Gln Gln Val Asp Met Gln Val Leu 
785                 790                 795                 800 


Val Tyr Gly Thr Arg Thr Ser Lys Asp Lys Ser Gly Ala Tyr Leu Phe 
                805                 810                 815     


Leu Pro Asp Gly Glu Ala Lys Pro Tyr Val Pro Lys Glu Pro Pro Val 
            820                 825                 830         


Leu Arg Val Thr Glu Gly Pro Phe Phe Ser Glu Val Val Ala Tyr Tyr 
        835                 840                 845             


Glu His Ile His Gln Ala Val Arg Leu Tyr Asn Leu Pro Gly Val Glu 
    850                 855                 860                 


Gly Leu Ser Leu Asp Ile Ser Ser Leu Val Asp Ile Arg Asp Tyr Val 
865                 870                 875                 880 


Asn Lys Glu Leu Ala Leu His Ile His Thr Asp Ile Asp Ser Gln Gly 
                885                 890                 895     


Ile Phe Phe Thr Asp Leu Asn Gly Phe Gln Val Gln Pro Arg Arg Tyr 
            900                 905                 910         


Leu Lys Lys Leu Pro Leu Gln Ala Asn Phe Tyr Pro Met Pro Val Met 
        915                 920                 925             


Ala Tyr Ile Gln Asp Ala Gln Lys Arg Leu Thr Leu His Thr Ala Gln 
    930                 935                 940                 


Ala Leu Gly Val Ser Ser Leu Lys Asp Gly Gln Leu Glu Val Ile Leu 
945                 950                 955                 960 


Asp Arg Arg Leu Met Gln Asp Asp Asn Arg Gly Leu Gly Gln Gly Leu 
                965                 970                 975     


Lys Asp Asn Lys Arg Thr Cys Asn Arg Phe Arg Leu Leu Leu Glu Arg 
            980                 985                 990         


Arg Thr Val Gly Ser Glu Val Gln  Asp Ser His Ser Thr  Ser Tyr Pro 
        995                 1000                 1005             


Ser Leu  Leu Ser His Leu Thr  Ser Met Tyr Leu Asn  Ala Pro Ala 
    1010                 1015                 1020             


Leu Ala  Leu Pro Val Ala Arg  Met Gln Leu Pro Gly  Pro Gly Leu 
    1025                 1030                 1035             


Arg Ser  Phe His Pro Leu Ala  Ser Ser Leu Pro Cys  Asp Phe His 
    1040                 1045                 1050             


Leu Leu  Asn Leu Arg Thr Leu  Gln Ala Glu Glu Asp  Thr Leu Pro 
    1055                 1060                 1065             


Ser Ala  Glu Thr Ala Leu Ile  Leu His Arg Lys Gly  Phe Asp Cys 
    1070                 1075                 1080             


Gly Leu  Glu Ala Lys Asn Leu  Gly Phe Asn Cys Thr  Thr Ser Gln 
    1085                 1090                 1095             


Gly Lys  Val Ala Leu Gly Ser  Leu Phe His Gly Leu  Asp Val Val 
    1100                 1105                 1110             


Phe Leu  Gln Pro Thr Ser Leu  Thr Leu Leu Tyr Pro  Leu Ala Ser 
    1115                 1120                 1125             


Pro Ser  Asn Ser Thr Asp Val  Tyr Leu Glu Pro Met  Glu Ile Ala 
    1130                 1135                 1140             


Thr Phe  Arg Leu Arg Leu Gly  
    1145                 1150 


<210>  3439
<211>  1042
<212>  PRT
<213>  Homo sapiens

<400>  3439

Met Pro Gly Ile Val Val Phe Arg Arg Arg Trp Ser Val Gly Ser Asp 
1               5                   10                  15      


Asp Leu Val Leu Pro Ala Ile Phe Leu Phe Leu Leu His Thr Thr Trp 
            20                  25                  30          


Phe Val Ile Leu Ser Val Val Leu Phe Gly Leu Val Tyr Asn Pro His 
        35                  40                  45              


Glu Ala Cys Ser Leu Asn Leu Val Asp His Gly Arg Gly Tyr Leu Gly 
    50                  55                  60                  


Ile Leu Leu Ser Cys Met Ile Ala Glu Met Ala Ile Ile Trp Leu Ser 
65                  70                  75                  80  


Met Arg Gly Gly Ile Leu Tyr Thr Glu Pro Arg Asp Ser Met Gln Tyr 
                85                  90                  95      


Val Leu Tyr Val Arg Leu Ala Ile Leu Val Ile Glu Phe Ile Tyr Ala 
            100                 105                 110         


Ile Val Gly Ile Val Trp Leu Thr Gln Tyr Tyr Thr Ser Cys Asn Asp 
        115                 120                 125             


Leu Thr Ala Lys Asn Val Thr Leu Gly Met Val Val Cys Asn Trp Val 
    130                 135                 140                 


Val Ile Leu Ser Val Cys Ile Thr Val Leu Cys Val Phe Asp Pro Thr 
145                 150                 155                 160 


Gly Arg Thr Phe Val Lys Leu Arg Ala Thr Lys Arg Arg Gln Arg Asn 
                165                 170                 175     


Leu Arg Thr Tyr Asn Leu Arg His Arg Leu Glu Glu Gly Gln Ala Thr 
            180                 185                 190         


Ser Trp Ser Arg Arg Leu Lys Val Phe Leu Cys Cys Thr Arg Thr Lys 
        195                 200                 205             


Asp Ser Gln Ser Asp Ala Tyr Ser Glu Ile Ala Tyr Leu Phe Ala Glu 
    210                 215                 220                 


Phe Phe Arg Asp Leu Asp Ile Val Pro Ser Asp Ile Ile Ala Gly Leu 
225                 230                 235                 240 


Val Leu Leu Arg Gln Arg Gln Arg Ala Lys Arg Asn Ala Val Leu Asp 
                245                 250                 255     


Glu Ala Asn Asn Asp Ile Leu Ala Phe Leu Ser Gly Met Pro Val Thr 
            260                 265                 270         


Arg Asn Thr Lys Tyr Leu Asp Leu Lys Asn Ser Gln Glu Met Leu Arg 
        275                 280                 285             


Tyr Lys Glu Val Cys Tyr Tyr Met Leu Phe Ala Leu Ala Ala Tyr Gly 
    290                 295                 300                 


Trp Pro Met Tyr Leu Met Arg Lys Pro Ala Cys Gly Leu Cys Gln Leu 
305                 310                 315                 320 


Ala Arg Ser Cys Ser Cys Cys Leu Cys Pro Ala Arg Pro Arg Phe Ala 
                325                 330                 335     


Pro Gly Val Thr Ile Glu Glu Asp Asn Cys Cys Gly Cys Asn Ala Ile 
            340                 345                 350         


Ala Ile Arg Arg His Phe Leu Asp Glu Asn Met Thr Ala Val Asp Ile 
        355                 360                 365             


Val Tyr Thr Ser Cys His Asp Ala Val Tyr Glu Thr Pro Phe Tyr Val 
    370                 375                 380                 


Ala Val Asp His Asp Lys Lys Lys Val Val Ile Ser Ile Arg Gly Thr 
385                 390                 395                 400 


Leu Ser Pro Lys Asp Ala Leu Thr Asp Leu Thr Gly Asp Ala Glu Arg 
                405                 410                 415     


Leu Pro Val Glu Gly His His Gly Thr Trp Leu Gly His Lys Gly Met 
            420                 425                 430         


Val Leu Ser Ala Glu Tyr Ile Lys Lys Lys Leu Glu Gln Glu Met Val 
        435                 440                 445             


Leu Ser Gln Ala Phe Gly Arg Asp Leu Gly Arg Gly Thr Lys His Tyr 
    450                 455                 460                 


Gly Leu Ile Val Val Gly His Ser Leu Gly Ala Gly Thr Ala Ala Ile 
465                 470                 475                 480 


Leu Ser Phe Leu Leu Arg Pro Gln Tyr Pro Thr Leu Lys Cys Phe Ala 
                485                 490                 495     


Tyr Ser Pro Pro Gly Gly Leu Leu Ser Glu Asp Ala Met Glu Tyr Ser 
            500                 505                 510         


Lys Glu Phe Val Thr Ala Val Val Leu Gly Lys Asp Leu Val Pro Arg 
        515                 520                 525             


Ile Gly Leu Ser Gln Leu Glu Gly Phe Arg Arg Gln Leu Leu Asp Val 
    530                 535                 540                 


Leu Gln Arg Ser Thr Lys Pro Lys Trp Arg Ile Ile Val Gly Ala Thr 
545                 550                 555                 560 


Lys Cys Ile Pro Lys Ser Glu Leu Pro Glu Glu Val Glu Val Thr Thr 
                565                 570                 575     


Leu Ala Ser Thr Arg Leu Trp Thr His Pro Ser Asp Leu Thr Ile Ala 
            580                 585                 590         


Leu Ser Ala Ser Thr Pro Leu Tyr Pro Pro Gly Arg Ile Ile His Val 
        595                 600                 605             


Val His Asn His Pro Ala Glu Gln Cys Cys Cys Cys Glu Gln Glu Glu 
    610                 615                 620                 


Pro Thr Tyr Phe Ala Ile Trp Gly Asp Asn Lys Ala Phe Asn Glu Val 
625                 630                 635                 640 


Ile Ile Ser Pro Ala Met Leu His Glu His Leu Pro Tyr Val Val Met 
                645                 650                 655     


Glu Gly Leu Asn Lys Val Leu Glu Asn Tyr Asn Lys Gly Lys Thr Ala 
            660                 665                 670         


Leu Leu Ser Ala Ala Lys Val Met Val Ser Pro Thr Glu Val Asp Leu 
        675                 680                 685             


Thr Pro Glu Leu Ile Phe Gln Gln Gln Pro Leu Pro Thr Gly Pro Pro 
    690                 695                 700                 


Met Pro Thr Gly Leu Ala Leu Glu Leu Pro Thr Ala Asp His Arg Asn 
705                 710                 715                 720 


Ser Ser Val Arg Ser Lys Ser Gln Ser Glu Met Ser Leu Glu Gly Phe 
                725                 730                 735     


Ser Glu Gly Arg Leu Leu Ser Pro Val Val Ala Ala Ala Ala Arg Gln 
            740                 745                 750         


Asp Pro Val Glu Leu Leu Leu Leu Ser Thr Gln Glu Arg Leu Ala Ala 
        755                 760                 765             


Glu Leu Gln Ala Arg Arg Ala Pro Leu Ala Thr Met Glu Ser Leu Ser 
    770                 775                 780                 


Asp Thr Glu Ser Leu Tyr Ser Phe Asp Ser Arg Arg Ser Ser Gly Phe 
785                 790                 795                 800 


Arg Ser Ile Arg Gly Ser Pro Ser Leu His Ala Val Leu Glu Arg Asp 
                805                 810                 815     


Glu Gly His Leu Phe Tyr Ile Asp Pro Ala Ile Pro Glu Glu Asn Pro 
            820                 825                 830         


Ser Leu Ser Ser Arg Thr Glu Leu Leu Ala Ala Asp Ser Leu Ser Lys 
        835                 840                 845             


His Ser Gln Asp Thr Gln Pro Leu Glu Ala Ala Leu Gly Ser Gly Gly 
    850                 855                 860                 


Val Thr Pro Glu Arg Pro Pro Ser Ala Ala Ala Asn Asp Glu Glu Glu 
865                 870                 875                 880 


Glu Val Gly Gly Gly Gly Gly Gly Pro Ala Ser Arg Gly Glu Leu Ala 
                885                 890                 895     


Leu His Asn Gly Arg Leu Gly Asp Ser Pro Ser Pro Gln Val Leu Glu 
            900                 905                 910         


Phe Ala Glu Phe Ile Asp Ser Leu Phe Asn Leu Asp Ser Lys Ser Ser 
        915                 920                 925             


Ser Phe Gln Asp Leu Tyr Cys Met Val Val Pro Glu Ser Pro Thr Ser 
    930                 935                 940                 


Asp Tyr Ala Glu Gly Pro Lys Ser Pro Ser Gln Gln Glu Ile Leu Leu 
945                 950                 955                 960 


Arg Ala Gln Phe Glu Pro Asn Leu Val Pro Lys Pro Pro Arg Leu Phe 
                965                 970                 975     


Ala Gly Ser Ala Asp Pro Ser Ser Gly Ile Ser Leu Ser Pro Ser Phe 
            980                 985                 990         


Pro Leu Ser Ser Ser Gly Glu Leu  Met Asp Leu Thr Pro  Thr Gly Leu 
        995                 1000                 1005             


Ser Ser  Gln Glu Cys Leu Ala  Ala Asp Lys Ile Arg  Thr Ser Thr 
    1010                 1015                 1020             


Pro Thr  Gly His Gly Ala Ser  Pro Ala Lys Gln Asp  Glu Leu Val 
    1025                 1030                 1035             


Ile Ser  Ala Arg 
    1040         


<210>  3440
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  3440

Met Ala Gly Phe Leu Asp Asn Phe Arg Trp Pro Glu Cys Glu Cys Ile 
1               5                   10                  15      


Asp Trp Ser Glu Arg Arg Asn Ala Val Ala Ser Val Val Ala Gly Ile 
            20                  25                  30          


Leu Phe Phe Thr Gly Trp Trp Ile Met Ile Asp Ala Ala Val Val Tyr 
        35                  40                  45              


Pro Lys Pro Glu Gln Leu Asn His Ala Phe His Thr Cys Gly Val Phe 
    50                  55                  60                  


Ser Thr Leu Ala Phe Phe Met Ile Asn Ala Val Ser Asn Ala Gln Val 
65                  70                  75                  80  


Arg Gly Asp Ser Tyr Glu Ser Gly Cys Leu Gly Arg Thr Gly Ala Arg 
                85                  90                  95      


Val Trp Leu Phe Ile Gly Phe Met Leu Met Phe Gly Ser Leu Ile Ala 
            100                 105                 110         


Ser Met Trp Ile Leu Phe Gly Ala Tyr Val Thr Gln Asn Thr Asp Val 
        115                 120                 125             


Tyr Pro Gly Leu Ala Val Phe Phe Gln Asn Ala Leu Ile Phe Phe Ser 
    130                 135                 140                 


Thr Leu Ile Tyr Lys Phe Gly Arg Thr Glu Glu Leu Trp Thr 
145                 150                 155             


<210>  3441
<211>  286
<212>  PRT
<213>  Homo sapiens

<400>  3441

Met Ala Asp Leu Glu Glu Gln Leu Ser Asp Glu Glu Lys Val Arg Ile 
1               5                   10                  15      


Ala Ala Lys Phe Ile Ile His Ala Pro Pro Gly Glu Phe Asn Glu Val 
            20                  25                  30          


Phe Asn Asp Val Arg Leu Leu Leu Asn Asn Asp Asn Leu Leu Arg Glu 
        35                  40                  45              


Gly Ala Ala His Ala Phe Ala Gln Tyr Asn Leu Asp Gln Phe Thr Pro 
    50                  55                  60                  


Val Lys Ile Glu Gly Tyr Glu Asp Gln Val Leu Ile Thr Glu His Gly 
65                  70                  75                  80  


Asp Leu Gly Asn Gly Lys Phe Leu Asp Pro Lys Asn Arg Ile Cys Phe 
                85                  90                  95      


Lys Phe Asp His Leu Arg Lys Glu Ala Thr Asp Pro Arg Pro Cys Glu 
            100                 105                 110         


Val Glu Asn Ala Val Glu Ser Trp Arg Thr Ser Val Glu Thr Ala Leu 
        115                 120                 125             


Arg Ala Tyr Val Lys Glu His Tyr Pro Asn Gly Val Cys Thr Val Tyr 
    130                 135                 140                 


Gly Lys Lys Ile Asp Gly Gln Gln Thr Ile Ile Ala Cys Ile Glu Ser 
145                 150                 155                 160 


His Gln Phe Gln Ala Lys Asn Phe Trp Asn Gly Arg Trp Arg Ser Glu 
                165                 170                 175     


Trp Lys Phe Thr Ile Thr Pro Ser Thr Thr Gln Val Val Gly Ile Leu 
            180                 185                 190         


Lys Ile Gln Val His Tyr Tyr Glu Asp Gly Asn Val Gln Leu Val Ser 
        195                 200                 205             


His Lys Asp Ile Gln Asp Ser Leu Thr Val Ser Asn Glu Val Gln Thr 
    210                 215                 220                 


Ala Lys Glu Phe Ile Lys Ile Val Glu Ala Ala Glu Asn Glu Tyr Gln 
225                 230                 235                 240 


Thr Ala Ile Ser Glu Asn Tyr Gln Thr Met Ser Asp Thr Thr Phe Lys 
                245                 250                 255     


Ala Leu Arg Arg Gln Leu Pro Val Thr Arg Thr Lys Ile Asp Trp Asn 
            260                 265                 270         


Lys Ile Leu Ser Tyr Lys Ile Gly Lys Glu Met Gln Asn Ala 
        275                 280                 285     


<210>  3442
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  3442

Met Ala Gly Pro Pro Arg Leu Leu Leu Leu Pro Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Arg Gly Leu Pro Gly Ala Leu Ala Ala Gln Glu Val Gln Gln Ser 
            20                  25                  30          


Pro His Cys Thr Thr Val Pro Val Gly Ala Ser Val Asn Ile Thr Cys 
        35                  40                  45              


Ser Thr Ser Gly Gly Leu Arg Gly Ile Tyr Leu Arg Gln Leu Gly Pro 
    50                  55                  60                  


Gln Pro Gln Asp Ile Ile Tyr Tyr Glu Asp Gly Val Val Pro Thr Thr 
65                  70                  75                  80  


Asp Arg Arg Phe Arg Gly Arg Ile Asp Phe Ser Gly Ser Gln Asp Asn 
                85                  90                  95      


Leu Thr Ile Thr Met His Arg Leu Gln Leu Ser Asp Thr Gly Thr Tyr 
            100                 105                 110         


Thr Cys Gln Ala Ile Thr Glu Val Asn Val Tyr Gly Ser Gly Thr Leu 
        115                 120                 125             


Val Leu Val Thr Glu Glu Gln Ser Gln Gly Trp His Arg Cys Ser Asp 
    130                 135                 140                 


Ala Pro Pro Arg Ala Ser Ala Leu Pro Ala Pro Pro Thr Gly Ser Ala 
145                 150                 155                 160 


Leu Pro Asp Pro Gln Thr Ala Ser Ala Leu Pro Asp Pro Pro Ala Ala 
                165                 170                 175     


Ser Ala Leu Pro Ala Ala Leu Ala Val Ile Ser Phe Leu Leu Gly Leu 
            180                 185                 190         


Gly Leu Gly Val Ala Cys Val Leu Ala Arg Thr Gln Ile Lys Lys Leu 
        195                 200                 205             


Cys Ser Trp Arg Asp Lys Asn Ser Ala Ala Cys Val Val Tyr Glu Asp 
    210                 215                 220                 


Met Ser His Ser Arg Cys Asn Thr Leu Ser Ser Pro Asn Gln Tyr Gln 
225                 230                 235                 240 


<210>  3443
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  3443

Met Ala Ser His Glu Val Asp Asn Ala Glu Leu Gly Ser Ala Ser Ala 
1               5                   10                  15      


His Gly Thr Pro Gly Ser Glu Ala Gly Pro Glu Glu Leu Asn Thr Ser 
            20                  25                  30          


Val Tyr Gln Pro Ile Asp Gly Ser Pro Asp Tyr Gln Lys Ala Lys Leu 
        35                  40                  45              


Gln Val Leu Gly Ala Ile Gln Ile Leu Asn Ala Ala Met Ile Leu Ala 
    50                  55                  60                  


Leu Gly Val Phe Leu Gly Ser Leu Gln Tyr Pro Tyr His Phe Gln Lys 
65                  70                  75                  80  


His Phe Phe Phe Phe Thr Phe Tyr Thr Gly Tyr Pro Ile Trp Gly Ala 
                85                  90                  95      


Val Phe Phe Cys Ser Ser Gly Thr Leu Ser Val Val Ala Gly Ile Lys 
            100                 105                 110         


Pro Thr Arg Thr Trp Ile Gln Asn Ser Phe Gly Met Asn Ile Ala Ser 
        115                 120                 125             


Ala Thr Ile Ala Leu Val Gly Thr Ala Phe Leu Ser Leu Asn Ile Ala 
    130                 135                 140                 


Val Asn Ile Gln Ser Leu Arg Ser Cys His Ser Ser Ser Glu Ser Pro 
145                 150                 155                 160 


Asp Leu Cys Asn Tyr Met Gly Ser Ile Ser Asn Gly Met Val Ser Leu 
                165                 170                 175     


Leu Leu Ile Leu Thr Leu Leu Glu Leu Cys Val Thr Ile Ser Thr Ile 
            180                 185                 190         


Ala Met Trp Cys Asn Ala Asn Cys Cys Asn Ser Arg Glu Glu Ile Ser 
        195                 200                 205             


Ser Pro Pro Asn Ser Val 
    210                 


<210>  3444
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  3444

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210>  3445
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  3445

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser 
65                  70                  75                  80  


Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val 
                85                  90                  95      


His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro 
            100                 105                 110         


Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile 
        115                 120                 125             


Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala 
    130                 135                 140                 


Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg 
145                 150                 155                 160 


Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val 
                165                 170                 175     


Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe 
            180                 185                 190         


Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser 
        195                 200                 205             


Leu Leu Asp Thr Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val 
    210                 215                 220                 


Thr Val Arg Cys Asn Thr Thr His Cys Leu Val Arg Trp Lys Gln Pro 
225                 230                 235                 240 


Arg Thr Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp 
                245                 250                 255     


Val His Arg Lys Asn Thr Gln Pro Gly Thr Glu Asn Leu Leu Ile Asn 
            260                 265                 270         


Val Ser Gly Asp Leu Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro 
        275                 280                 285             


Arg Ala Lys His Ser Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu 
    290                 295                 300                 


Asn Trp Ser Ser Trp Ser Glu Ala Ile Glu Phe Gly Ser Asp Asp Gly 
305                 310                 315                 320 


Asn Leu Gly Ser Val Tyr Ile Tyr Val Leu Leu Ile Val Gly Thr Leu 
                325                 330                 335     


Val Cys Gly Ile Val Leu Gly Phe Leu Phe Lys Arg Phe Leu Arg Ile 
            340                 345                 350         


Gln Arg Leu Phe Pro Pro Val Pro Gln Ile Lys Asp Lys Leu Asn Asp 
        355                 360                 365             


Asn His Glu Val Glu Asp Glu Ile Ile Trp Glu Glu Phe Thr Pro Glu 
    370                 375                 380                 


Glu Gly Lys Gly Tyr Arg Glu Glu Val Leu Thr Val Lys Glu Ile Thr 
385                 390                 395                 400 


<210>  3446
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  3446

Met Val Phe Ala His Arg Met Asp Asn Ser Lys Pro His Leu Ile Ile 
1               5                   10                  15      


Pro Thr Leu Leu Val Pro Leu Gln Asn Arg Ser Cys Thr Glu Thr Ala 
            20                  25                  30          


Thr Pro Leu Pro Ser Gln Tyr Leu Met Glu Leu Ser Glu Glu His Ser 
        35                  40                  45              


Trp Met Ser Asn Gln Thr Asp Leu His Tyr Val Leu Lys Pro Gly Glu 
    50                  55                  60                  


Val Ala Thr Ala Ser Ile Phe Phe Gly Ile Leu Trp Leu Phe Ser Ile 
65                  70                  75                  80  


Phe Gly Asn Ser Leu Val Cys Leu Val Ile His Arg Ser Arg Arg Thr 
                85                  90                  95      


Gln Ser Thr Thr Asn Tyr Phe Val Val Ser Met Ala Cys Ala Asp Leu 
            100                 105                 110         


Leu Ile Ser Val Ala Ser Thr Pro Phe Val Leu Leu Gln Phe Thr Thr 
        115                 120                 125             


Gly Arg Trp Thr Leu Gly Ser Ala Thr Cys Lys Val Val Arg Tyr Phe 
    130                 135                 140                 


Gln Tyr Leu Thr Pro Gly Val Gln Ile Tyr Val Leu Leu Ser Ile Cys 
145                 150                 155                 160 


Ile Asp Arg Phe Tyr Thr Ile Val Tyr Pro Leu Ser Phe Lys Val Ser 
                165                 170                 175     


Arg Glu Lys Ala Lys Lys Met Ile Ala Ala Ser Trp Ile Phe Asp Ala 
            180                 185                 190         


Gly Phe Val Thr Pro Val Leu Phe Phe Tyr Gly Ser Asn Trp Asp Ser 
        195                 200                 205             


His Cys Asn Tyr Phe Leu Pro Ser Ser Trp Glu Gly Thr Ala Tyr Thr 
    210                 215                 220                 


Val Ile His Phe Leu Val Gly Phe Val Ile Pro Ser Val Leu Ile Ile 
225                 230                 235                 240 


Leu Phe Tyr Gln Lys Val Ile Lys Tyr Ile Trp Arg Ile Gly Thr Asp 
                245                 250                 255     


Gly Arg Thr Val Arg Arg Thr Met Asn Ile Val Pro Arg Thr Lys Val 
            260                 265                 270         


Lys Thr Ile Lys Met Phe Leu Ile Leu Asn Leu Leu Phe Leu Leu Ser 
        275                 280                 285             


Trp Leu Pro Phe His Val Ala Gln Leu Trp His Pro His Glu Gln Asp 
    290                 295                 300                 


Tyr Lys Lys Ser Ser Leu Val Phe Thr Ala Ile Thr Trp Ile Ser Phe 
305                 310                 315                 320 


Ser Ser Ser Ala Ser Lys Pro Thr Leu Tyr Ser Ile Tyr Asn Ala Asn 
                325                 330                 335     


Phe Arg Arg Gly Met Lys Glu Thr Phe Cys Met Ser Ser Met Lys Cys 
            340                 345                 350         


Tyr Arg Ser Asn Ala Tyr Thr Ile Thr Thr Ser Ser Arg Met Ala Lys 
        355                 360                 365             


Lys Asn Tyr Val Gly Ile Ser Glu Ile Pro Ser Met Ala Lys Thr Ile 
    370                 375                 380                 


Thr Lys Asp Ser Ile Tyr Asp Ser Phe Asp Arg Glu Ala Lys Glu Lys 
385                 390                 395                 400 


Lys Leu Ala Trp Pro Ile Asn Ser Asn Pro Pro Asn Thr Phe Val 
                405                 410                 415 


<210>  3447
<211>  499
<212>  PRT
<213>  Homo sapiens

<400>  3447

Met Asn Asp Asp Pro Ser Met Glu Glu Asn Gly Val Glu Arg Val Cys 
1               5                   10                  15      


Pro Glu Ser Leu Leu Gln Ser Arg Glu Tyr Ser Ser Leu Pro Leu Pro 
            20                  25                  30          


Arg His Thr Ser Ser Thr Asp Gly Thr Ile Thr Ser Ser Asp Pro Gly 
        35                  40                  45              


Leu Glu Ile Leu Asn Met Ala Ser Cys Asp Leu Asp Arg Asn Ser Leu 
    50                  55                  60                  


Cys Lys Lys Glu Glu Asp Thr Arg Ser Ala Ser Pro Thr Ile Glu Ala 
65                  70                  75                  80  


Gln Gly Thr Ser Pro Ala His Asp Asn Ile Ala Phe Gln Asp Ser Thr 
                85                  90                  95      


Ser Lys Asp Lys Thr Ile Leu Asn Leu Glu Ala Lys Glu Glu Pro Glu 
            100                 105                 110         


Thr Ile Glu Glu His Lys Lys Glu His Ala Ser Gly Asp Ser Val Val 
        115                 120                 125             


Ser Pro Leu Pro Val Thr Thr Val Lys Ser Val Asn Leu Arg Gln Ser 
    130                 135                 140                 


Glu Asn Thr Ser Ala Asn Glu Lys Glu Val Glu Ala Glu Phe Leu Arg 
145                 150                 155                 160 


Leu Ser Leu Gly Phe Lys Cys Asp Trp Phe Thr Leu Glu Lys Arg Val 
                165                 170                 175     


Lys Leu Glu Glu Arg Ser Arg Asp Leu Ala Glu Glu Asn Leu Lys Lys 
            180                 185                 190         


Glu Ile Thr Asn Cys Leu Lys Leu Leu Glu Ser Leu Thr Pro Leu Cys 
        195                 200                 205             


Glu Asp Asp Asn Gln Ala Gln Glu Ile Ile Lys Lys Leu Glu Lys Ser 
    210                 215                 220                 


Ile Lys Phe Leu Ser Gln Cys Ala Ala Arg Val Ala Ser Arg Ala Glu 
225                 230                 235                 240 


Met Leu Gly Ala Ile Asn Gln Glu Ser Arg Val Ser Lys Ala Val Glu 
                245                 250                 255     


Val Met Ile Gln His Val Glu Asn Leu Lys Arg Met Tyr Ala Lys Glu 
            260                 265                 270         


His Ala Glu Leu Glu Glu Leu Lys Gln Val Leu Leu Gln Asn Glu Arg 
        275                 280                 285             


Ser Phe Asn Pro Leu Glu Asp Asp Asp Asp Cys Gln Ile Lys Lys Arg 
    290                 295                 300                 


Ser Ala Ser Leu Asn Ser Lys Pro Ser Ser Leu Arg Arg Val Thr Ile 
305                 310                 315                 320 


Ala Ser Leu Pro Arg Asn Ile Gly Asn Ala Gly Met Val Ala Gly Met 
                325                 330                 335     


Glu Asn Asn Asp Arg Phe Ser Arg Arg Ser Ser Ser Trp Arg Ile Leu 
            340                 345                 350         


Gly Ser Lys Gln Ser Glu His Arg Pro Ser Leu Pro Arg Phe Ile Ser 
        355                 360                 365             


Thr Tyr Ser Trp Ala Asp Ala Glu Glu Glu Lys Cys Glu Leu Lys Thr 
    370                 375                 380                 


Lys Asp Asp Ser Glu Pro Ser Gly Glu Glu Thr Val Glu Arg Thr Arg 
385                 390                 395                 400 


Lys Pro Ser Leu Ser Glu Lys Lys Asn Asn Pro Ser Lys Trp Asp Val 
                405                 410                 415     


Ser Ser Val Tyr Asp Thr Ile Ala Ser Trp Ala Thr Asn Leu Lys Ser 
            420                 425                 430         


Ser Ile Arg Lys Ala Asn Lys Ala Leu Trp Leu Ser Ile Ala Phe Ile 
        435                 440                 445             


Val Leu Phe Ala Ala Leu Met Ser Phe Leu Thr Gly Gln Leu Phe Gln 
    450                 455                 460                 


Lys Ser Val Asp Ala Ala Pro Thr Gln Gln Glu Asp Ser Trp Thr Ser 
465                 470                 475                 480 


Leu Glu His Ile Leu Trp Pro Phe Thr Arg Leu Arg His Asn Gly Pro 
                485                 490                 495     


Pro Pro Val 
            


<210>  3448
<211>  816
<212>  PRT
<213>  Homo sapiens

<400>  3448

Met Glu Ser Arg Val Leu Leu Arg Thr Phe Cys Leu Ile Phe Gly Leu 
1               5                   10                  15      


Gly Ala Val Trp Gly Leu Gly Val Asp Pro Ser Leu Gln Ile Asp Val 
            20                  25                  30          


Leu Thr Glu Leu Glu Leu Gly Glu Ser Thr Thr Gly Val Arg Gln Val 
        35                  40                  45              


Pro Gly Leu His Asn Gly Thr Lys Ala Phe Leu Phe Gln Asp Thr Pro 
    50                  55                  60                  


Arg Ser Ile Lys Ala Ser Thr Ala Thr Ala Glu Gln Phe Phe Gln Lys 
65                  70                  75                  80  


Leu Arg Asn Lys His Glu Phe Thr Ile Leu Val Thr Leu Lys Gln Thr 
                85                  90                  95      


His Leu Asn Ser Gly Val Ile Leu Ser Ile His His Leu Asp His Arg 
            100                 105                 110         


Tyr Leu Glu Leu Glu Ser Ser Gly His Arg Asn Glu Val Arg Leu His 
        115                 120                 125             


Tyr Arg Ser Gly Ser His Arg Pro His Thr Glu Val Phe Pro Tyr Ile 
    130                 135                 140                 


Leu Ala Asp Asp Lys Trp His Lys Leu Ser Leu Ala Ile Ser Ala Ser 
145                 150                 155                 160 


His Leu Ile Leu His Ile Asp Cys Asn Lys Ile Tyr Glu Arg Val Val 
                165                 170                 175     


Glu Lys Pro Ser Thr Asp Leu Pro Leu Gly Thr Thr Phe Trp Leu Gly 
            180                 185                 190         


Gln Arg Asn Asn Ala His Gly Tyr Phe Lys Gly Ile Met Gln Asp Val 
        195                 200                 205             


Gln Leu Leu Val Met Pro Gln Gly Phe Ile Ala Gln Cys Pro Asp Leu 
    210                 215                 220                 


Asn Arg Thr Cys Pro Thr Cys Asn Asp Phe His Gly Leu Val Gln Lys 
225                 230                 235                 240 


Ile Met Glu Leu Gln Asp Ile Leu Ala Lys Thr Ser Ala Lys Leu Ser 
                245                 250                 255     


Arg Ala Glu Gln Arg Met Asn Arg Leu Asp Gln Cys Tyr Cys Glu Arg 
            260                 265                 270         


Thr Cys Thr Met Lys Gly Thr Thr Tyr Arg Glu Phe Glu Ser Trp Ile 
        275                 280                 285             


Asp Gly Cys Lys Asn Cys Thr Cys Leu Asn Gly Thr Ile Gln Cys Glu 
    290                 295                 300                 


Thr Leu Ile Cys Pro Asn Pro Asp Cys Pro Leu Lys Ser Ala Leu Ala 
305                 310                 315                 320 


Tyr Val Asp Gly Lys Cys Cys Lys Glu Cys Lys Ser Ile Cys Gln Phe 
                325                 330                 335     


Gln Gly Arg Thr Tyr Phe Glu Gly Glu Arg Asn Thr Val Tyr Ser Ser 
            340                 345                 350         


Ser Gly Val Cys Val Leu Tyr Glu Cys Lys Asp Gln Thr Met Lys Leu 
        355                 360                 365             


Val Glu Ser Ser Gly Cys Pro Ala Leu Asp Cys Pro Glu Ser His Gln 
    370                 375                 380                 


Ile Thr Leu Ser His Ser Cys Cys Lys Val Cys Lys Gly Tyr Asp Phe 
385                 390                 395                 400 


Cys Ser Glu Arg His Asn Cys Met Glu Asn Ser Ile Cys Arg Asn Leu 
                405                 410                 415     


Asn Asp Arg Ala Val Cys Ser Cys Arg Asp Gly Phe Arg Ala Leu Arg 
            420                 425                 430         


Glu Asp Asn Ala Tyr Cys Glu Asp Ile Asp Glu Cys Ala Glu Gly Arg 
        435                 440                 445             


His Tyr Cys Arg Glu Asn Thr Met Cys Val Asn Thr Pro Gly Ser Phe 
    450                 455                 460                 


Met Cys Ile Cys Lys Thr Gly Tyr Ile Arg Ile Asp Asp Tyr Ser Cys 
465                 470                 475                 480 


Thr Glu His Asp Glu Cys Ile Thr Asn Gln His Asn Cys Asp Glu Asn 
                485                 490                 495     


Ala Leu Cys Phe Asn Thr Val Gly Gly His Asn Cys Val Cys Lys Pro 
            500                 505                 510         


Gly Tyr Thr Gly Asn Gly Thr Thr Cys Lys Ala Phe Cys Lys Asp Gly 
        515                 520                 525             


Cys Arg Asn Gly Gly Ala Cys Ile Ala Ala Asn Val Cys Ala Cys Pro 
    530                 535                 540                 


Gln Gly Phe Thr Gly Pro Ser Cys Glu Thr Asp Ile Asp Glu Cys Ser 
545                 550                 555                 560 


Asp Gly Phe Val Gln Cys Asp Ser Arg Ala Asn Cys Ile Asn Leu Pro 
                565                 570                 575     


Gly Trp Tyr His Cys Glu Cys Arg Asp Gly Tyr His Asp Asn Gly Met 
            580                 585                 590         


Phe Ser Pro Ser Gly Glu Ser Cys Glu Asp Ile Asp Glu Cys Gly Thr 
        595                 600                 605             


Gly Arg His Ser Cys Ala Asn Asp Thr Ile Cys Phe Asn Leu Asp Gly 
    610                 615                 620                 


Gly Tyr Asp Cys Arg Cys Pro His Gly Lys Asn Cys Thr Gly Asp Cys 
625                 630                 635                 640 


Ile His Asp Gly Lys Val Lys His Asn Gly Gln Ile Trp Val Leu Glu 
                645                 650                 655     


Asn Asp Arg Cys Ser Val Cys Ser Cys Gln Asn Gly Phe Val Met Cys 
            660                 665                 670         


Arg Arg Met Val Cys Asp Cys Glu Asn Pro Thr Val Asp Leu Phe Cys 
        675                 680                 685             


Cys Pro Glu Cys Asp Pro Arg Leu Ser Ser Gln Cys Leu His Gln Asn 
    690                 695                 700                 


Gly Glu Thr Leu Tyr Asn Ser Gly Asp Thr Trp Val Gln Asn Cys Gln 
705                 710                 715                 720 


Gln Cys Arg Cys Leu Gln Gly Glu Val Asp Cys Trp Pro Leu Pro Cys 
                725                 730                 735     


Pro Asp Val Glu Cys Glu Phe Ser Ile Leu Pro Glu Asn Glu Cys Cys 
            740                 745                 750         


Pro Arg Cys Val Thr Asp Pro Cys Gln Ala Asp Thr Ile Arg Asn Asp 
        755                 760                 765             


Ile Thr Lys Thr Cys Leu Asp Glu Met Asn Val Val Arg Phe Thr Gly 
    770                 775                 780                 


Ser Ser Trp Ile Lys His Gly Thr Glu Cys Thr Leu Cys Gln Cys Lys 
785                 790                 795                 800 


Asn Gly His Ile Cys Cys Ser Val Asp Pro Gln Cys Leu Gln Glu Leu 
                805                 810                 815     


<210>  3449
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  3449

Met Ser Ser Phe Ser Thr Thr Thr Val Ser Phe Leu Leu Leu Leu Ala 
1               5                   10                  15      


Phe Gln Leu Leu Gly Gln Thr Arg Ala Asn Pro Met Tyr Asn Ala Val 
            20                  25                  30          


Ser Asn Ala Asp Leu Met Asp Phe Lys Asn Leu Leu Asp His Leu Glu 
        35                  40                  45              


Glu Lys Met Pro Leu Glu Asp Glu Val Val Pro Pro Gln Val Leu Ser 
    50                  55                  60                  


Glu Pro Asn Glu Glu Ala Gly Ala Ala Leu Ser Pro Leu Pro Glu Val 
65                  70                  75                  80  


Pro Pro Trp Thr Gly Glu Val Ser Pro Ala Gln Arg Asp Gly Gly Ala 
                85                  90                  95      


Leu Gly Arg Gly Pro Trp Asp Ser Ser Asp Arg Ser Ala Leu Leu Lys 
            100                 105                 110         


Ser Lys Leu Arg Ala Leu Leu Thr Ala Pro Arg Ser Leu Arg Arg Ser 
        115                 120                 125             


Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly Ala Gln Ser Gly Leu 
    130                 135                 140                 


Gly Cys Asn Ser Phe Arg Tyr 
145                 150     


<210>  3450
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  3450

Met Asp Leu Glu Leu Asp Glu Tyr Tyr Asn Lys Thr Leu Ala Thr Glu 
1               5                   10                  15      


Asn Asn Thr Ala Ala Thr Arg Asn Ser Asp Phe Pro Val Trp Asp Asp 
            20                  25                  30          


Tyr Lys Ser Ser Val Asp Asp Leu Gln Tyr Phe Leu Ile Gly Leu Tyr 
        35                  40                  45              


Thr Phe Val Ser Leu Leu Gly Phe Met Gly Asn Leu Leu Ile Leu Met 
    50                  55                  60                  


Ala Leu Met Lys Lys Arg Asn Gln Lys Thr Thr Val Asn Phe Leu Ile 
65                  70                  75                  80  


Gly Asn Leu Ala Phe Ser Asp Ile Leu Val Val Leu Phe Cys Ser Pro 
                85                  90                  95      


Phe Thr Leu Thr Ser Val Leu Leu Asp Gln Trp Met Phe Gly Lys Val 
            100                 105                 110         


Met Cys His Ile Met Pro Phe Leu Gln Cys Val Ser Val Leu Val Ser 
        115                 120                 125             


Thr Leu Ile Leu Ile Ser Ile Ala Ile Val Arg Tyr His Met Ile Lys 
    130                 135                 140                 


His Pro Ile Ser Asn Asn Leu Thr Ala Asn His Gly Tyr Phe Leu Ile 
145                 150                 155                 160 


Ala Thr Val Trp Thr Leu Gly Phe Ala Ile Cys Ser Pro Leu Pro Val 
                165                 170                 175     


Phe His Ser Leu Val Glu Leu Gln Glu Thr Phe Gly Ser Ala Leu Leu 
            180                 185                 190         


Ser Ser Arg Tyr Leu Cys Val Glu Ser Trp Pro Ser Asp Ser Tyr Arg 
        195                 200                 205             


Ile Ala Phe Thr Ile Ser Leu Leu Leu Val Gln Tyr Ile Leu Pro Leu 
    210                 215                 220                 


Val Cys Leu Thr Val Ser His Thr Ser Val Cys Arg Ser Ile Ser Cys 
225                 230                 235                 240 


Gly Leu Ser Asn Lys Glu Asn Arg Leu Glu Glu Asn Glu Met Ile Asn 
                245                 250                 255     


Leu Thr Leu His Pro Ser Lys Lys Ser Gly Pro Gln Val Lys Leu Ser 
            260                 265                 270         


Gly Ser His Lys Trp Ser Tyr Ser Phe Ile Lys Lys His Arg Arg Arg 
        275                 280                 285             


Tyr Ser Lys Lys Thr Ala Cys Val Leu Pro Ala Pro Glu Arg Pro Ser 
    290                 295                 300                 


Gln Glu Asn His Ser Arg Ile Leu Pro Glu Asn Phe Gly Ser Val Arg 
305                 310                 315                 320 


Ser Gln Leu Ser Ser Ser Ser Lys Phe Ile Pro Gly Val Pro Thr Cys 
                325                 330                 335     


Phe Glu Ile Lys Pro Glu Glu Asn Ser Asp Val His Glu Leu Arg Val 
            340                 345                 350         


Lys Arg Ser Val Thr Arg Ile Lys Lys Arg Ser Arg Ser Val Phe Tyr 
        355                 360                 365             


Arg Leu Thr Ile Leu Ile Leu Val Phe Ala Val Ser Trp Met Pro Leu 
    370                 375                 380                 


His Leu Phe His Val Val Thr Asp Phe Asn Asp Asn Leu Ile Ser Asn 
385                 390                 395                 400 


Arg His Phe Lys Leu Val Tyr Cys Ile Cys His Leu Leu Gly Met Met 
                405                 410                 415     


Ser Cys Cys Leu Asn Pro Ile Leu Tyr Gly Phe Leu Asn Asn Gly Ile 
            420                 425                 430         


Lys Ala Asp Leu Val Ser Leu Ile His Cys Leu His Met 
        435                 440                 445 


<210>  3451
<211>  838
<212>  PRT
<213>  Homo sapiens

<400>  3451

Met Ser Ser Trp Ile Arg Trp His Gly Pro Ala Met Ala Arg Leu Trp 
1               5                   10                  15      


Gly Phe Cys Trp Leu Val Val Gly Phe Trp Arg Ala Ala Phe Ala Cys 
            20                  25                  30          


Pro Thr Ser Cys Lys Cys Ser Ala Ser Arg Ile Trp Cys Ser Asp Pro 
        35                  40                  45              


Ser Pro Gly Ile Val Ala Phe Pro Arg Leu Glu Pro Asn Ser Val Asp 
    50                  55                  60                  


Pro Glu Asn Ile Thr Glu Ile Phe Ile Ala Asn Gln Lys Arg Leu Glu 
65                  70                  75                  80  


Ile Ile Asn Glu Asp Asp Val Glu Ala Tyr Val Gly Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Asp Ser Gly Leu Lys Phe Val Ala His Lys Ala Phe Leu 
            100                 105                 110         


Lys Asn Ser Asn Leu Gln His Ile Asn Phe Thr Arg Asn Lys Leu Thr 
        115                 120                 125             


Ser Leu Ser Arg Lys His Phe Arg His Leu Asp Leu Ser Glu Leu Ile 
    130                 135                 140                 


Leu Val Gly Asn Pro Phe Thr Cys Ser Cys Asp Ile Met Trp Ile Lys 
145                 150                 155                 160 


Thr Leu Gln Glu Ala Lys Ser Ser Pro Asp Thr Gln Asp Leu Tyr Cys 
                165                 170                 175     


Leu Asn Glu Ser Ser Lys Asn Ile Pro Leu Ala Asn Leu Gln Ile Pro 
            180                 185                 190         


Asn Cys Gly Leu Pro Ser Ala Asn Leu Ala Ala Pro Asn Leu Thr Val 
        195                 200                 205             


Glu Glu Gly Lys Ser Ile Thr Leu Ser Cys Ser Val Ala Gly Asp Pro 
    210                 215                 220                 


Val Pro Asn Met Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His Met 
225                 230                 235                 240 


Asn Glu Thr Ser His Thr Gln Gly Ser Leu Arg Ile Thr Asn Ile Ser 
                245                 250                 255     


Ser Asp Asp Ser Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu Val 
            260                 265                 270         


Gly Glu Asp Gln Asp Ser Val Asn Leu Thr Val His Phe Ala Pro Thr 
        275                 280                 285             


Ile Thr Phe Leu Glu Ser Pro Thr Ser Asp His His Trp Cys Ile Pro 
    290                 295                 300                 


Phe Thr Val Lys Gly Asn Pro Lys Pro Ala Leu Gln Trp Phe Tyr Asn 
305                 310                 315                 320 


Gly Ala Ile Leu Asn Glu Ser Lys Tyr Ile Cys Thr Lys Ile His Val 
                325                 330                 335     


Thr Asn His Thr Glu Tyr His Gly Cys Leu Gln Leu Asp Asn Pro Thr 
            340                 345                 350         


His Met Asn Asn Gly Asp Tyr Thr Leu Ile Ala Lys Asn Glu Tyr Gly 
        355                 360                 365             


Lys Asp Glu Lys Gln Ile Ser Ala His Phe Met Gly Trp Pro Gly Ile 
    370                 375                 380                 


Asp Asp Gly Ala Asn Pro Asn Tyr Pro Asp Val Ile Tyr Glu Asp Tyr 
385                 390                 395                 400 


Gly Thr Ala Ala Asn Asp Ile Gly Asp Thr Thr Asn Arg Ser Asn Glu 
                405                 410                 415     


Ile Pro Ser Thr Asp Val Thr Asp Lys Thr Gly Arg Glu His Leu Ser 
            420                 425                 430         


Val Tyr Ala Val Val Val Ile Ala Ser Val Val Gly Phe Cys Leu Leu 
        435                 440                 445             


Val Met Leu Phe Leu Leu Lys Leu Ala Arg His Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Asp Phe Ser Trp Phe Gly Phe Gly Lys Val Lys Ser Arg Gln Gly 
465                 470                 475                 480 


Val Gly Pro Ala Ser Val Ile Ser Asn Asp Asp Asp Ser Ala Ser Pro 
                485                 490                 495     


Leu His His Ile Ser Asn Gly Ser Asn Thr Pro Ser Ser Ser Glu Gly 
            500                 505                 510         


Gly Pro Asp Ala Val Ile Ile Gly Met Thr Lys Ile Pro Val Ile Glu 
        515                 520                 525             


Asn Pro Gln Tyr Phe Gly Ile Thr Asn Ser Gln Leu Lys Pro Asp Thr 
    530                 535                 540                 


Phe Val Gln His Ile Lys Arg His Asn Ile Val Leu Lys Arg Glu Leu 
545                 550                 555                 560 


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu 
                565                 570                 575     


Cys Pro Glu Gln Asp Lys Ile Leu Val Ala Val Lys Thr Leu Lys Asp 
            580                 585                 590         


Ala Ser Asp Asn Ala Arg Lys Asp Phe His Arg Glu Ala Glu Leu Leu 
        595                 600                 605             


Thr Asn Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Val 
    610                 615                 620                 


Glu Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp 
625                 630                 635                 640 


Leu Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala Val Leu Met Ala 
                645                 650                 655     


Glu Gly Asn Pro Pro Thr Glu Leu Thr Gln Ser Gln Met Leu His Ile 
            660                 665                 670         


Ala Gln Gln Ile Ala Ala Gly Met Val Tyr Leu Ala Ser Gln His Phe 
        675                 680                 685             


Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Glu Asn Leu 
    690                 695                 700                 


Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val Tyr Ser Thr 
705                 710                 715                 720 


Asp Tyr Tyr Arg Val Gly Gly His Thr Met Leu Pro Ile Arg Trp Met 
                725                 730                 735     


Pro Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val 
            740                 745                 750         


Trp Ser Leu Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln 
        755                 760                 765             


Pro Trp Tyr Gln Leu Ser Asn Asn Glu Val Ile Glu Cys Ile Thr Gln 
    770                 775                 780                 


Gly Arg Val Leu Gln Arg Pro Arg Thr Cys Pro Gln Glu Val Tyr Glu 
785                 790                 795                 800 


Leu Met Leu Gly Cys Trp Gln Arg Glu Pro His Met Arg Lys Asn Ile 
                805                 810                 815     


Lys Gly Ile His Thr Leu Leu Gln Asn Leu Ala Lys Ala Ser Pro Val 
            820                 825                 830         


Tyr Leu Asp Ile Leu Gly 
        835             


<210>  3452
<211>  855
<212>  PRT
<213>  Homo sapiens

<400>  3452

Met Ile Leu Ile Pro Arg Met Leu Leu Val Leu Phe Leu Leu Leu Pro 
1               5                   10                  15      


Ile Leu Ser Ser Ala Lys Ala Gln Val Asn Pro Ala Ile Cys Arg Tyr 
            20                  25                  30          


Pro Leu Gly Met Ser Gly Gly Gln Ile Pro Asp Glu Asp Ile Thr Ala 
        35                  40                  45              


Ser Ser Gln Trp Ser Glu Ser Thr Ala Ala Lys Tyr Gly Arg Leu Asp 
    50                  55                  60                  


Ser Glu Glu Gly Asp Gly Ala Trp Cys Pro Glu Ile Pro Val Glu Pro 
65                  70                  75                  80  


Asp Asp Leu Lys Glu Phe Leu Gln Ile Asp Leu His Thr Leu His Phe 
                85                  90                  95      


Ile Thr Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly His Gly Ile 
            100                 105                 110         


Glu Phe Ala Pro Met Tyr Lys Ile Asn Tyr Ser Arg Asp Gly Thr Arg 
        115                 120                 125             


Trp Ile Ser Trp Arg Asn Arg His Gly Lys Gln Val Leu Asp Gly Asn 
    130                 135                 140                 


Ser Asn Pro Tyr Asp Ile Phe Leu Lys Asp Leu Glu Pro Pro Ile Val 
145                 150                 155                 160 


Ala Arg Phe Val Arg Phe Ile Pro Val Thr Asp His Ser Met Asn Val 
                165                 170                 175     


Cys Met Arg Val Glu Leu Tyr Gly Cys Val Trp Leu Asp Gly Leu Val 
            180                 185                 190         


Ser Tyr Asn Ala Pro Ala Gly Gln Gln Phe Val Leu Pro Gly Gly Ser 
        195                 200                 205             


Ile Ile Tyr Leu Asn Asp Ser Val Tyr Asp Gly Ala Val Gly Tyr Ser 
    210                 215                 220                 


Met Thr Glu Gly Leu Gly Gln Leu Thr Asp Gly Val Ser Gly Leu Asp 
225                 230                 235                 240 


Asp Phe Thr Gln Thr His Glu Tyr His Val Trp Pro Gly Tyr Asp Tyr 
                245                 250                 255     


Val Gly Trp Arg Asn Glu Ser Ala Thr Asn Gly Tyr Ile Glu Ile Met 
            260                 265                 270         


Phe Glu Phe Asp Arg Ile Arg Asn Phe Thr Thr Met Lys Val His Cys 
        275                 280                 285             


Asn Asn Met Phe Ala Lys Gly Val Lys Ile Phe Lys Glu Val Gln Cys 
    290                 295                 300                 


Tyr Phe Arg Ser Glu Ala Ser Glu Trp Glu Pro Asn Ala Ile Ser Phe 
305                 310                 315                 320 


Pro Leu Val Leu Asp Asp Val Asn Pro Ser Ala Arg Phe Val Thr Val 
                325                 330                 335     


Pro Leu His His Arg Met Ala Ser Ala Ile Lys Cys Gln Tyr His Phe 
            340                 345                 350         


Ala Asp Thr Trp Met Met Phe Ser Glu Ile Thr Phe Gln Ser Asp Ala 
        355                 360                 365             


Ala Met Tyr Asn Asn Ser Glu Ala Leu Pro Thr Ser Pro Met Ala Pro 
    370                 375                 380                 


Thr Thr Tyr Asp Pro Met Leu Lys Val Asp Asp Ser Asn Thr Arg Ile 
385                 390                 395                 400 


Leu Ile Gly Cys Leu Val Ala Ile Ile Phe Ile Leu Leu Ala Ile Ile 
                405                 410                 415     


Val Ile Ile Leu Trp Arg Gln Phe Trp Gln Lys Met Leu Glu Lys Ala 
            420                 425                 430         


Ser Arg Arg Met Leu Asp Asp Glu Met Thr Val Ser Leu Ser Leu Pro 
        435                 440                 445             


Ser Asp Ser Ser Met Phe Asn Asn Asn Arg Ser Ser Ser Pro Ser Glu 
    450                 455                 460                 


Gln Gly Ser Asn Ser Thr Tyr Asp Arg Ile Phe Pro Leu Arg Pro Asp 
465                 470                 475                 480 


Tyr Gln Glu Pro Ser Arg Leu Ile Arg Lys Leu Pro Glu Phe Ala Pro 
                485                 490                 495     


Gly Glu Glu Glu Ser Gly Cys Ser Gly Val Val Lys Pro Val Gln Pro 
            500                 505                 510         


Ser Gly Pro Glu Gly Val Pro His Tyr Ala Glu Ala Asp Ile Val Asn 
        515                 520                 525             


Leu Gln Gly Val Thr Gly Gly Asn Thr Tyr Ser Val Pro Ala Val Thr 
    530                 535                 540                 


Met Asp Leu Leu Ser Gly Lys Asp Val Ala Val Glu Glu Phe Pro Arg 
545                 550                 555                 560 


Lys Leu Leu Thr Phe Lys Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu 
                565                 570                 575     


Val His Leu Cys Glu Val Glu Gly Met Glu Lys Phe Lys Asp Lys Asp 
            580                 585                 590         


Phe Ala Leu Asp Val Ser Ala Asn Gln Pro Val Leu Val Ala Val Lys 
        595                 600                 605             


Met Leu Arg Ala Asp Ala Asn Lys Asn Ala Arg Asn Asp Phe Leu Lys 
    610                 615                 620                 


Glu Ile Lys Ile Met Ser Arg Leu Lys Asp Pro Asn Ile Ile His Leu 
625                 630                 635                 640 


Leu Ala Val Cys Ile Thr Asp Asp Pro Leu Cys Met Ile Thr Glu Tyr 
                645                 650                 655     


Met Glu Asn Gly Asp Leu Asn Gln Phe Leu Ser Arg His Glu Pro Pro 
            660                 665                 670         


Asn Ser Ser Ser Ser Asp Val Arg Thr Val Ser Tyr Thr Asn Leu Lys 
        675                 680                 685             


Phe Met Ala Thr Gln Ile Ala Ser Gly Met Lys Tyr Leu Ser Ser Leu 
    690                 695                 700                 


Asn Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Lys 
705                 710                 715                 720 


Asn Tyr Thr Ile Lys Ile Ala Asp Phe Gly Met Ser Arg Asn Leu Tyr 
                725                 730                 735     


Ser Gly Asp Tyr Tyr Arg Ile Gln Gly Arg Ala Val Leu Pro Ile Arg 
            740                 745                 750         


Trp Met Ser Trp Glu Ser Ile Leu Leu Gly Lys Phe Thr Thr Ala Ser 
        755                 760                 765             


Asp Val Trp Ala Phe Gly Val Thr Leu Trp Glu Thr Phe Thr Phe Cys 
    770                 775                 780                 


Gln Glu Gln Pro Tyr Ser Gln Leu Ser Asp Glu Gln Val Ile Glu Asn 
785                 790                 795                 800 


Thr Gly Glu Phe Phe Arg Asp Gln Gly Arg Gln Thr Tyr Leu Pro Gln 
                805                 810                 815     


Pro Ala Ile Cys Pro Asp Ser Val Tyr Lys Leu Met Leu Ser Cys Trp 
            820                 825                 830         


Arg Arg Asp Thr Lys Asn Arg Pro Ser Phe Gln Glu Ile His Leu Leu 
        835                 840                 845             


Leu Leu Gln Gln Gly Asp Glu 
    850                 855 


<210>  3453
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  3453

Met Pro Pro Ser Gly Pro Arg Gly Thr Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Arg Ala Val Leu Ala Val Pro Leu Glu Arg Gly 
            20                  25                  30          


Ala Pro Asn Lys Glu Glu Thr Pro Ala Thr Glu Ser Pro Asp Thr Gly 
        35                  40                  45              


Leu Tyr Tyr His Arg Tyr Leu Gln Glu Val Ile Asp Val Leu Glu Thr 
    50                  55                  60                  


Asp Gly His Phe Arg Glu Lys Leu Gln Ala Ala Asn Ala Glu Asp Ile 
65                  70                  75                  80  


Lys Ser Gly Lys Leu Ser Arg Glu Leu Asp Phe Val Ser His His Val 
                85                  90                  95      


Arg Thr Lys Leu Asp Glu Leu Lys Arg Gln Glu Val Ser Arg Leu Arg 
            100                 105                 110         


Met Leu Leu Lys Ala Lys Met Asp Ala Glu Gln Asp Pro Asn Val Gln 
        115                 120                 125             


Val Asp His Leu Asn Leu Leu Lys Gln Phe Glu His Leu Asp Pro Gln 
    130                 135                 140                 


Asn Gln His Thr Phe Glu Ala Arg Asp Leu Glu Leu Leu Ile Gln Thr 
145                 150                 155                 160 


Ala Thr Arg Asp Leu Ala Gln Tyr Asp Ala Ala His His Glu Glu Phe 
                165                 170                 175     


Lys Arg Tyr Glu Met Leu Lys Glu His Glu Arg Arg Arg Tyr Leu Glu 
            180                 185                 190         


Ser Leu Gly Glu Glu Gln Arg Lys Glu Ala Glu Arg Lys Leu Glu Glu 
        195                 200                 205             


Gln Gln Arg Arg His Arg Glu His Pro Lys Val Asn Val Pro Gly Ser 
    210                 215                 220                 


Gln Ala Gln Leu Lys Glu Val Trp Glu Glu Leu Asp Gly Leu Asp Pro 
225                 230                 235                 240 


Asn Arg Phe Asn Pro Lys Thr Phe Phe Ile Leu His Asp Ile Asn Ser 
                245                 250                 255     


Asp Gly Val Leu Asp Glu Gln Glu Leu Glu Ala Leu Phe Thr Lys Glu 
            260                 265                 270         


Leu Glu Lys Val Tyr Asp Pro Lys Asn Glu Glu Asp Asp Met Arg Glu 
        275                 280                 285             


Met Glu Glu Glu Arg Leu Arg Met Arg Glu His Val Met Lys Asn Val 
    290                 295                 300                 


Asp Thr Asn Gln Asp Arg Leu Val Thr Leu Glu Glu Phe Leu Ala Ser 
305                 310                 315                 320 


Thr Gln Arg Lys Glu Phe Gly Asp Thr Gly Glu Gly Trp Glu Thr Val 
                325                 330                 335     


Glu Met His Pro Ala Tyr Thr Glu Glu Glu Leu Arg Arg Phe Glu Glu 
            340                 345                 350         


Glu Leu Ala Ala Arg Glu Ala Glu Leu Asn Ala Lys Ala Gln Arg Leu 
        355                 360                 365             


Ser Gln Glu Thr Glu Ala Leu Gly Arg Ser Gln Gly Arg Leu Glu Ala 
    370                 375                 380                 


Gln Lys Arg Glu Leu Gln Gln Ala Val Leu His Met Glu Gln Arg Lys 
385                 390                 395                 400 


Gln Gln Gln Gln Gln Gln Gln Gly His Lys Ala Pro Ala Ala His Pro 
                405                 410                 415     


Glu Gly Gln Leu Lys Phe His Pro Asp Thr Asp Asp Val Pro Val Pro 
            420                 425                 430         


Ala Pro Ala Gly Asp Gln Lys Glu Val Asp Thr Ser Glu Lys Lys Leu 
        435                 440                 445             


Leu Glu Arg Leu Pro Glu Val Glu Val Pro Gln His Leu 
    450                 455                 460     


<210>  3454
<211>  913
<212>  PRT
<213>  Homo sapiens

<400>  3454

Met Gly Trp Gly Ser Arg Cys Cys Cys Pro Gly Arg Leu Asp Leu Leu 
1               5                   10                  15      


Cys Val Leu Ala Leu Leu Gly Gly Cys Leu Leu Pro Val Cys Arg Thr 
            20                  25                  30          


Arg Val Tyr Thr Asn His Trp Ala Val Lys Ile Ala Gly Gly Phe Pro 
        35                  40                  45              


Glu Ala Asn Arg Ile Ala Ser Lys Tyr Gly Phe Ile Asn Ile Gly Gln 
    50                  55                  60                  


Ile Gly Ala Leu Lys Asp Tyr Tyr His Phe Tyr His Ser Arg Thr Ile 
65                  70                  75                  80  


Lys Arg Ser Val Ile Ser Ser Arg Gly Thr His Ser Phe Ile Ser Met 
                85                  90                  95      


Glu Pro Lys Val Glu Trp Ile Gln Gln Gln Val Val Lys Lys Arg Thr 
            100                 105                 110         


Lys Arg Asp Tyr Asp Phe Ser Arg Ala Gln Ser Thr Tyr Phe Asn Asp 
        115                 120                 125             


Pro Lys Trp Pro Ser Met Trp Tyr Met His Cys Ser Asp Asn Thr His 
    130                 135                 140                 


Pro Cys Gln Ser Asp Met Asn Ile Glu Gly Ala Trp Lys Arg Gly Tyr 
145                 150                 155                 160 


Thr Gly Lys Asn Ile Val Val Thr Ile Leu Asp Asp Gly Ile Glu Arg 
                165                 170                 175     


Thr His Pro Asp Leu Met Gln Asn Tyr Asp Ala Leu Ala Ser Cys Asp 
            180                 185                 190         


Val Asn Gly Asn Asp Leu Asp Pro Met Pro Arg Tyr Asp Ala Ser Asn 
        195                 200                 205             


Glu Asn Lys His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala Ala Ala 
    210                 215                 220                 


Asn Asn Ser His Cys Thr Val Gly Ile Ala Phe Asn Ala Lys Ile Gly 
225                 230                 235                 240 


Gly Val Arg Met Leu Asp Gly Asp Val Thr Asp Met Val Glu Ala Lys 
                245                 250                 255     


Ser Val Ser Phe Asn Pro Gln His Val His Ile Tyr Ser Ala Ser Trp 
            260                 265                 270         


Gly Pro Asp Asp Asp Gly Lys Thr Val Asp Gly Pro Ala Pro Leu Thr 
        275                 280                 285             


Arg Gln Ala Phe Glu Asn Gly Val Arg Met Gly Arg Arg Gly Leu Gly 
    290                 295                 300                 


Ser Val Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Ser Lys Asp His 
305                 310                 315                 320 


Cys Ser Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Ile Ser Ile Ser 
                325                 330                 335     


Ser Thr Ala Glu Ser Gly Lys Lys Pro Trp Tyr Leu Glu Glu Cys Ser 
            340                 345                 350         


Ser Thr Leu Ala Thr Thr Tyr Ser Ser Gly Glu Ser Tyr Asp Lys Lys 
        355                 360                 365             


Ile Ile Thr Thr Asp Leu Arg Gln Arg Cys Thr Asp Asn His Thr Gly 
    370                 375                 380                 


Thr Ser Ala Ser Ala Pro Met Ala Ala Gly Ile Ile Ala Leu Ala Leu 
385                 390                 395                 400 


Glu Ala Asn Pro Phe Leu Thr Trp Arg Asp Val Gln His Val Ile Val 
                405                 410                 415     


Arg Thr Ser Arg Ala Gly His Leu Asn Ala Asn Asp Trp Lys Thr Asn 
            420                 425                 430         


Ala Ala Gly Phe Lys Val Ser His Leu Tyr Gly Phe Gly Leu Met Asp 
        435                 440                 445             


Ala Glu Ala Met Val Met Glu Ala Glu Lys Trp Thr Thr Val Pro Arg 
    450                 455                 460                 


Gln His Val Cys Val Glu Ser Thr Asp Arg Gln Ile Lys Thr Ile Arg 
465                 470                 475                 480 


Pro Asn Ser Ala Val Arg Ser Ile Tyr Lys Ala Ser Gly Cys Ser Asp 
                485                 490                 495     


Asn Pro Asn Arg His Val Asn Tyr Leu Glu His Val Val Val Arg Ile 
            500                 505                 510         


Thr Ile Thr His Pro Arg Arg Gly Asp Leu Ala Ile Tyr Leu Thr Ser 
        515                 520                 525             


Pro Ser Gly Thr Arg Ser Gln Leu Leu Ala Asn Arg Leu Phe Asp His 
    530                 535                 540                 


Ser Met Glu Gly Phe Lys Asn Trp Glu Phe Met Thr Ile His Cys Trp 
545                 550                 555                 560 


Gly Glu Arg Ala Ala Gly Asp Trp Val Leu Glu Val Tyr Asp Thr Pro 
                565                 570                 575     


Ser Gln Leu Arg Asn Phe Lys Thr Pro Gly Lys Leu Lys Glu Trp Ser 
            580                 585                 590         


Leu Val Leu Tyr Gly Thr Ser Val Gln Pro Tyr Ser Pro Thr Asn Glu 
        595                 600                 605             


Phe Pro Lys Val Glu Arg Phe Arg Tyr Ser Arg Val Glu Asp Pro Thr 
    610                 615                 620                 


Asp Asp Tyr Gly Thr Glu Asp Tyr Ala Gly Pro Cys Asp Pro Glu Cys 
625                 630                 635                 640 


Ser Glu Val Gly Cys Asp Gly Pro Gly Pro Asp His Cys Asn Asp Cys 
                645                 650                 655     


Leu His Tyr Tyr Tyr Lys Leu Lys Asn Asn Thr Arg Ile Cys Val Ser 
            660                 665                 670         


Ser Cys Pro Pro Gly His Tyr His Ala Asp Lys Lys Arg Cys Arg Lys 
        675                 680                 685             


Cys Ala Pro Asn Cys Glu Ser Cys Phe Gly Ser His Gly Asp Gln Cys 
    690                 695                 700                 


Met Ser Cys Lys Tyr Gly Tyr Phe Leu Asn Glu Glu Thr Asn Ser Cys 
705                 710                 715                 720 


Val Thr His Cys Pro Asp Gly Ser Tyr Gln Asp Thr Lys Lys Asn Leu 
                725                 730                 735     


Cys Arg Lys Cys Ser Glu Asn Cys Lys Thr Cys Thr Glu Phe His Asn 
            740                 745                 750         


Cys Thr Glu Cys Arg Asp Gly Leu Ser Leu Gln Gly Ser Arg Cys Ser 
        755                 760                 765             


Val Ser Cys Glu Asp Gly Arg Tyr Phe Asn Gly Gln Asp Cys Gln Pro 
    770                 775                 780                 


Cys His Arg Phe Cys Ala Thr Cys Ala Gly Ala Gly Ala Asp Gly Cys 
785                 790                 795                 800 


Ile Asn Cys Thr Glu Gly Tyr Phe Met Glu Asp Gly Arg Cys Val Gln 
                805                 810                 815     


Ser Cys Ser Ile Ser Tyr Tyr Phe Asp His Ser Ser Glu Asn Gly Tyr 
            820                 825                 830         


Lys Ser Cys Lys Lys Cys Asp Ile Ser Cys Leu Thr Cys Asn Gly Pro 
        835                 840                 845             


Gly Phe Lys Asn Cys Thr Ser Cys Pro Ser Gly Tyr Leu Leu Asp Leu 
    850                 855                 860                 


Gly Met Cys Gln Met Gly Ala Ile Cys Lys Asp Ala Thr Glu Glu Ser 
865                 870                 875                 880 


Trp Ala Glu Gly Gly Phe Cys Met Leu Val Lys Lys Asn Asn Leu Cys 
                885                 890                 895     


Gln Arg Lys Val Leu Gln Gln Leu Cys Cys Lys Thr Cys Thr Phe Gln 
            900                 905                 910         


Gly 
    


<210>  3455
<211>  1089
<212>  PRT
<213>  Homo sapiens

<400>  3455

Met Gly Thr Ser His Pro Ala Phe Leu Val Leu Gly Cys Leu Leu Thr 
1               5                   10                  15      


Gly Leu Ser Leu Ile Leu Cys Gln Leu Ser Leu Pro Ser Ile Leu Pro 
            20                  25                  30          


Asn Glu Asn Glu Lys Val Val Gln Leu Asn Ser Ser Phe Ser Leu Arg 
        35                  40                  45              


Cys Phe Gly Glu Ser Glu Val Ser Trp Gln Tyr Pro Met Ser Glu Glu 
    50                  55                  60                  


Glu Ser Ser Asp Val Glu Ile Arg Asn Glu Glu Asn Asn Ser Gly Leu 
65                  70                  75                  80  


Phe Val Thr Val Leu Glu Val Ser Ser Ala Ser Ala Ala His Thr Gly 
                85                  90                  95      


Leu Tyr Thr Cys Tyr Tyr Asn His Thr Gln Thr Glu Glu Asn Glu Leu 
            100                 105                 110         


Glu Gly Arg His Ile Tyr Ile Tyr Val Pro Asp Pro Asp Val Ala Phe 
        115                 120                 125             


Val Pro Leu Gly Met Thr Asp Tyr Leu Val Ile Val Glu Asp Asp Asp 
    130                 135                 140                 


Ser Ala Ile Ile Pro Cys Arg Thr Thr Asp Pro Glu Thr Pro Val Thr 
145                 150                 155                 160 


Leu His Asn Ser Glu Gly Val Val Pro Ala Ser Tyr Asp Ser Arg Gln 
                165                 170                 175     


Gly Phe Asn Gly Thr Phe Thr Val Gly Pro Tyr Ile Cys Glu Ala Thr 
            180                 185                 190         


Val Lys Gly Lys Lys Phe Gln Thr Ile Pro Phe Asn Val Tyr Ala Leu 
        195                 200                 205             


Lys Ala Thr Ser Glu Leu Asp Leu Glu Met Glu Ala Leu Lys Thr Val 
    210                 215                 220                 


Tyr Lys Ser Gly Glu Thr Ile Val Val Thr Cys Ala Val Phe Asn Asn 
225                 230                 235                 240 


Glu Val Val Asp Leu Gln Trp Thr Tyr Pro Gly Glu Val Lys Gly Lys 
                245                 250                 255     


Gly Ile Thr Met Leu Glu Glu Ile Lys Val Pro Ser Ile Lys Leu Val 
            260                 265                 270         


Tyr Thr Leu Thr Val Pro Glu Ala Thr Val Lys Asp Ser Gly Asp Tyr 
        275                 280                 285             


Glu Cys Ala Ala Arg Gln Ala Thr Arg Glu Val Lys Glu Met Lys Lys 
    290                 295                 300                 


Val Thr Ile Ser Val His Glu Lys Gly Phe Ile Glu Ile Lys Pro Thr 
305                 310                 315                 320 


Phe Ser Gln Leu Glu Ala Val Asn Leu His Glu Val Lys His Phe Val 
                325                 330                 335     


Val Glu Val Arg Ala Tyr Pro Pro Pro Arg Ile Ser Trp Leu Lys Asn 
            340                 345                 350         


Asn Leu Thr Leu Ile Glu Asn Leu Thr Glu Ile Thr Thr Asp Val Glu 
        355                 360                 365             


Lys Ile Gln Glu Ile Arg Tyr Arg Ser Lys Leu Lys Leu Ile Arg Ala 
    370                 375                 380                 


Lys Glu Glu Asp Ser Gly His Tyr Thr Ile Val Ala Gln Asn Glu Asp 
385                 390                 395                 400 


Ala Val Lys Ser Tyr Thr Phe Glu Leu Leu Thr Gln Val Pro Ser Ser 
                405                 410                 415     


Ile Leu Asp Leu Val Asp Asp His His Gly Ser Thr Gly Gly Gln Thr 
            420                 425                 430         


Val Arg Cys Thr Ala Glu Gly Thr Pro Leu Pro Asp Ile Glu Trp Met 
        435                 440                 445             


Ile Cys Lys Asp Ile Lys Lys Cys Asn Asn Glu Thr Ser Trp Thr Ile 
    450                 455                 460                 


Leu Ala Asn Asn Val Ser Asn Ile Ile Thr Glu Ile His Ser Arg Asp 
465                 470                 475                 480 


Arg Ser Thr Val Glu Gly Arg Val Thr Phe Ala Lys Val Glu Glu Thr 
                485                 490                 495     


Ile Ala Val Arg Cys Leu Ala Lys Asn Leu Leu Gly Ala Glu Asn Arg 
            500                 505                 510         


Glu Leu Lys Leu Val Ala Pro Thr Leu Arg Ser Glu Leu Thr Val Ala 
        515                 520                 525             


Ala Ala Val Leu Val Leu Leu Val Ile Val Ile Ile Ser Leu Ile Val 
    530                 535                 540                 


Leu Val Val Ile Trp Lys Gln Lys Pro Arg Tyr Glu Ile Arg Trp Arg 
545                 550                 555                 560 


Val Ile Glu Ser Ile Ser Pro Asp Gly His Glu Tyr Ile Tyr Val Asp 
                565                 570                 575     


Pro Met Gln Leu Pro Tyr Asp Ser Arg Trp Glu Phe Pro Arg Asp Gly 
            580                 585                 590         


Leu Val Leu Gly Arg Val Leu Gly Ser Gly Ala Phe Gly Lys Val Val 
        595                 600                 605             


Glu Gly Thr Ala Tyr Gly Leu Ser Arg Ser Gln Pro Val Met Lys Val 
    610                 615                 620                 


Ala Val Lys Met Leu Lys Pro Thr Ala Arg Ser Ser Glu Lys Gln Ala 
625                 630                 635                 640 


Leu Met Ser Glu Leu Lys Ile Met Thr His Leu Gly Pro His Leu Asn 
                645                 650                 655     


Ile Val Asn Leu Leu Gly Ala Cys Thr Lys Ser Gly Pro Ile Tyr Ile 
            660                 665                 670         


Ile Thr Glu Tyr Cys Phe Tyr Gly Asp Leu Val Asn Tyr Leu His Lys 
        675                 680                 685             


Asn Arg Asp Ser Phe Leu Ser His His Pro Glu Lys Pro Lys Lys Glu 
    690                 695                 700                 


Leu Asp Ile Phe Gly Leu Asn Pro Ala Asp Glu Ser Thr Arg Ser Tyr 
705                 710                 715                 720 


Val Ile Leu Ser Phe Glu Asn Asn Gly Asp Tyr Met Asp Met Lys Gln 
                725                 730                 735     


Ala Asp Thr Thr Gln Tyr Val Pro Met Leu Glu Arg Lys Glu Val Ser 
            740                 745                 750         


Lys Tyr Ser Asp Ile Gln Arg Ser Leu Tyr Asp Arg Pro Ala Ser Tyr 
        755                 760                 765             


Lys Lys Lys Ser Met Leu Asp Ser Glu Val Lys Asn Leu Leu Ser Asp 
    770                 775                 780                 


Asp Asn Ser Glu Gly Leu Thr Leu Leu Asp Leu Leu Ser Phe Thr Tyr 
785                 790                 795                 800 


Gln Val Ala Arg Gly Met Glu Phe Leu Ala Ser Lys Asn Cys Val His 
                805                 810                 815     


Arg Asp Leu Ala Ala Arg Asn Val Leu Leu Ala Gln Gly Lys Ile Val 
            820                 825                 830         


Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile Met His Asp Ser Asn 
        835                 840                 845             


Tyr Val Ser Lys Gly Ser Thr Phe Leu Pro Val Lys Trp Met Ala Pro 
    850                 855                 860                 


Glu Ser Ile Phe Asp Asn Leu Tyr Thr Thr Leu Ser Asp Val Trp Ser 
865                 870                 875                 880 


Tyr Gly Ile Leu Leu Trp Glu Ile Phe Ser Leu Gly Gly Thr Pro Tyr 
                885                 890                 895     


Pro Gly Met Met Val Asp Ser Thr Phe Tyr Asn Lys Ile Lys Ser Gly 
            900                 905                 910         


Tyr Arg Met Ala Lys Pro Asp His Ala Thr Ser Glu Val Tyr Glu Ile 
        915                 920                 925             


Met Val Lys Cys Trp Asn Ser Glu Pro Glu Lys Arg Pro Ser Phe Tyr 
    930                 935                 940                 


His Leu Ser Glu Ile Val Glu Asn Leu Leu Pro Gly Gln Tyr Lys Lys 
945                 950                 955                 960 


Ser Tyr Glu Lys Ile His Leu Asp Phe Leu Lys Ser Asp His Pro Ala 
                965                 970                 975     


Val Ala Arg Met Arg Val Asp Ser Asp Asn Ala Tyr Ile Gly Val Thr 
            980                 985                 990         


Tyr Lys Asn Glu Glu Asp Lys Leu  Lys Asp Trp Glu Gly  Gly Leu Asp 
        995                 1000                 1005             


Glu Gln  Arg Leu Ser Ala Asp  Ser Gly Tyr Ile Ile  Pro Leu Pro 
    1010                 1015                 1020             


Asp Ile  Asp Pro Val Pro Glu  Glu Glu Asp Leu Gly  Lys Arg Asn 
    1025                 1030                 1035             


Arg His  Ser Ser Gln Thr Ser  Glu Glu Ser Ala Ile  Glu Thr Gly 
    1040                 1045                 1050             


Ser Ser  Ser Ser Thr Phe Ile  Lys Arg Glu Asp Glu  Thr Ile Glu 
    1055                 1060                 1065             


Asp Ile  Asp Met Met Asp Asp  Ile Gly Ile Asp Ser  Ser Asp Leu 
    1070                 1075                 1080             


Val Glu  Asp Ser Phe Leu 
    1085                 


<210>  3456
<211>  925
<212>  PRT
<213>  Homo sapiens

<400>  3456

Met Glu Arg Asp Gly Cys Ala Gly Gly Gly Ser Arg Gly Gly Glu Gly 
1               5                   10                  15      


Gly Arg Ala Pro Arg Glu Gly Pro Ala Gly Asn Gly Arg Asp Arg Gly 
            20                  25                  30          


Arg Ser His Ala Ala Glu Ala Pro Gly Asp Pro Gln Ala Ala Ala Ser 
        35                  40                  45              


Leu Leu Ala Pro Met Asp Val Gly Glu Glu Pro Leu Glu Lys Ala Ala 
    50                  55                  60                  


Arg Ala Arg Thr Ala Lys Asp Pro Asn Thr Tyr Lys Val Leu Ser Leu 
65                  70                  75                  80  


Val Leu Ser Val Cys Val Leu Thr Thr Ile Leu Gly Cys Ile Phe Gly 
                85                  90                  95      


Leu Lys Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg Cys 
            100                 105                 110         


Phe Glu Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val Glu 
        115                 120                 125             


Leu Gly Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro Glu 
    130                 135                 140                 


His Ile Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu Thr 
145                 150                 155                 160 


Arg Ser Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp Cys 
                165                 170                 175     


Cys Ile Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val Glu 
            180                 185                 190         


Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe Glu 
        195                 200                 205             


Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr 
    210                 215                 220                 


Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Lys 
225                 230                 235                 240 


Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys Thr 
                245                 250                 255     


Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser His 
            260                 265                 270         


Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser Phe 
        275                 280                 285             


Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly Glu 
    290                 295                 300                 


Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr Phe 
305                 310                 315                 320 


Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe Pro Asp Ile 
                325                 330                 335     


Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu Ala 
            340                 345                 350         


Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe Tyr 
        355                 360                 365             


Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly Pro 
    370                 375                 380                 


Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly Met Val 
385                 390                 395                 400 


Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys Leu 
                405                 410                 415     


Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser Cys Lys 
            420                 425                 430         


Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile Lys 
        435                 440                 445             


Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro Asp 
    450                 455                 460                 


Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser Cys 
465                 470                 475                 480 


Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu Pro 
                485                 490                 495     


Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr Phe 
            500                 505                 510         


Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg Lys 
        515                 520                 525             


Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser Asn Met 
    530                 535                 540                 


Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly Ile Glu 
545                 550                 555                 560 


Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu 
                565                 570                 575     


Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn 
            580                 585                 590         


His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu Val 
        595                 600                 605             


His Pro Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn Leu 
    610                 615                 620                 


Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln Thr 
625                 630                 635                 640 


Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His Glu Thr 
                645                 650                 655     


Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn Thr Ile Cys 
            660                 665                 670         


Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile Leu 
        675                 680                 685             


Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe Ser 
    690                 695                 700                 


Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Pro Leu 
705                 710                 715                 720 


Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val Ser 
                725                 730                 735     


Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly Ile 
            740                 745                 750         


Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln Ser 
        755                 760                 765             


Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg Lys Tyr 
    770                 775                 780                 


Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val Phe Asp 
785                 790                 795                 800 


Phe Asp Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg Gln Lys 
                805                 810                 815     


Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe Phe 
            820                 825                 830         


Ile Val Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu His Cys 
        835                 840                 845             


Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp Asn 
    850                 855                 860                 


Ser Glu Ser Cys Val His Gly Lys His Asp Ser Ser Trp Val Glu Glu 
865                 870                 875                 880 


Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile Thr 
                885                 890                 895     


Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp Ile Leu 
            900                 905                 910         


Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp 
        915                 920                 925 


<210>  3457
<211>  915
<212>  PRT
<213>  Homo sapiens

<400>  3457

Met Ala Arg Arg Ser Ser Phe Gln Ser Cys Gln Ile Ile Ser Leu Phe 
1               5                   10                  15      


Thr Phe Ala Val Gly Val Asn Ile Cys Leu Gly Phe Thr Ala His Arg 
            20                  25                  30          


Ile Lys Arg Ala Glu Gly Trp Glu Glu Gly Pro Pro Thr Val Leu Ser 
        35                  40                  45              


Asp Ser Pro Trp Thr Asn Ile Ser Gly Ser Cys Lys Gly Arg Cys Phe 
    50                  55                  60                  


Glu Leu Gln Glu Ala Gly Pro Pro Asp Cys Arg Cys Asp Asn Leu Cys 
65                  70                  75                  80  


Lys Ser Tyr Thr Ser Cys Cys His Asp Phe Asp Glu Leu Cys Leu Lys 
                85                  90                  95      


Thr Ala Arg Gly Trp Glu Cys Thr Lys Asp Arg Cys Gly Glu Val Arg 
            100                 105                 110         


Asn Glu Glu Asn Ala Cys His Cys Ser Glu Asp Cys Leu Ala Arg Gly 
        115                 120                 125             


Asp Cys Cys Thr Asn Tyr Gln Val Val Cys Lys Gly Glu Ser His Trp 
    130                 135                 140                 


Val Asp Asp Asp Cys Glu Glu Ile Lys Ala Ala Glu Cys Pro Ala Gly 
145                 150                 155                 160 


Phe Val Arg Pro Pro Leu Ile Ile Phe Ser Val Asp Gly Phe Arg Ala 
                165                 170                 175     


Ser Tyr Met Lys Lys Gly Ser Lys Val Met Pro Asn Ile Glu Lys Leu 
            180                 185                 190         


Arg Ser Cys Gly Thr His Ser Pro Tyr Met Arg Pro Val Tyr Pro Thr 
        195                 200                 205             


Lys Thr Phe Pro Asn Leu Tyr Thr Leu Ala Thr Gly Leu Tyr Pro Glu 
    210                 215                 220                 


Ser His Gly Ile Val Gly Asn Ser Met Tyr Asp Pro Val Phe Asp Ala 
225                 230                 235                 240 


Thr Phe His Leu Arg Gly Arg Glu Lys Phe Asn His Arg Trp Trp Gly 
                245                 250                 255     


Gly Gln Pro Leu Trp Ile Thr Ala Thr Lys Gln Gly Val Lys Ala Gly 
            260                 265                 270         


Thr Phe Phe Trp Ser Val Val Ile Pro His Glu Arg Arg Ile Leu Thr 
        275                 280                 285             


Ile Leu Gln Trp Leu Thr Leu Pro Asp His Glu Arg Pro Ser Val Tyr 
    290                 295                 300                 


Ala Phe Tyr Ser Glu Gln Pro Asp Phe Ser Gly His Lys Tyr Gly Pro 
305                 310                 315                 320 


Phe Gly Pro Glu Glu Ser Ser Tyr Gly Ser Pro Phe Thr Pro Ala Lys 
                325                 330                 335     


Arg Pro Lys Arg Lys Val Ala Pro Lys Arg Arg Gln Glu Arg Pro Val 
            340                 345                 350         


Ala Pro Pro Lys Lys Arg Arg Arg Lys Ile His Arg Met Asp His Tyr 
        355                 360                 365             


Ala Ala Glu Thr Arg Gln Asp Lys Met Thr Asn Pro Leu Arg Glu Ile 
    370                 375                 380                 


Asp Lys Ile Val Gly Gln Leu Met Asp Gly Leu Lys Gln Leu Lys Leu 
385                 390                 395                 400 


His Arg Cys Val Asn Val Ile Phe Val Gly Asp His Gly Met Glu Asp 
                405                 410                 415     


Val Thr Cys Asp Arg Thr Glu Phe Leu Ser Asn Tyr Leu Thr Asn Val 
            420                 425                 430         


Asp Asp Ile Thr Leu Val Pro Gly Thr Leu Gly Arg Ile Arg Ser Lys 
        435                 440                 445             


Phe Ser Asn Asn Ala Lys Tyr Asp Pro Lys Ala Ile Ile Ala Asn Leu 
    450                 455                 460                 


Thr Cys Lys Lys Pro Asp Gln His Phe Lys Pro Tyr Leu Lys Gln His 
465                 470                 475                 480 


Leu Pro Lys Arg Leu His Tyr Ala Asn Asn Arg Arg Ile Glu Asp Ile 
                485                 490                 495     


His Leu Leu Val Glu Arg Arg Trp His Val Ala Arg Lys Pro Leu Asp 
            500                 505                 510         


Val Tyr Lys Lys Pro Ser Gly Lys Cys Phe Phe Gln Gly Asp His Gly 
        515                 520                 525             


Phe Asp Asn Lys Val Asn Ser Met Gln Thr Val Phe Val Gly Tyr Gly 
    530                 535                 540                 


Ser Thr Phe Lys Tyr Lys Thr Lys Val Pro Pro Phe Glu Asn Ile Glu 
545                 550                 555                 560 


Leu Tyr Asn Val Met Cys Asp Leu Leu Gly Leu Lys Pro Ala Pro Asn 
                565                 570                 575     


Asn Gly Thr His Gly Ser Leu Asn His Leu Leu Arg Thr Asn Thr Phe 
            580                 585                 590         


Arg Pro Thr Met Pro Glu Glu Val Thr Arg Pro Asn Tyr Pro Gly Ile 
        595                 600                 605             


Met Tyr Leu Gln Ser Asp Phe Asp Leu Gly Cys Thr Cys Asp Asp Lys 
    610                 615                 620                 


Val Glu Pro Lys Asn Lys Leu Asp Glu Leu Asn Lys Arg Leu His Thr 
625                 630                 635                 640 


Lys Gly Ser Thr Glu Glu Arg His Leu Leu Tyr Gly Arg Pro Ala Val 
                645                 650                 655     


Leu Tyr Arg Thr Arg Tyr Asp Ile Leu Tyr His Thr Asp Phe Glu Ser 
            660                 665                 670         


Gly Tyr Ser Glu Ile Phe Leu Met Pro Leu Trp Thr Ser Tyr Thr Val 
        675                 680                 685             


Ser Lys Gln Ala Glu Val Ser Ser Val Pro Asp His Leu Thr Ser Cys 
    690                 695                 700                 


Val Arg Pro Asp Val Arg Val Ser Pro Ser Phe Ser Gln Asn Cys Leu 
705                 710                 715                 720 


Ala Tyr Lys Asn Asp Lys Gln Met Ser Tyr Gly Phe Leu Phe Pro Pro 
                725                 730                 735     


Tyr Leu Ser Ser Ser Pro Glu Ala Lys Tyr Asp Ala Phe Leu Val Thr 
            740                 745                 750         


Asn Met Val Pro Met Tyr Pro Ala Phe Lys Arg Val Trp Asn Tyr Phe 
        755                 760                 765             


Gln Arg Val Leu Val Lys Lys Tyr Ala Ser Glu Arg Asn Gly Val Asn 
    770                 775                 780                 


Val Ile Ser Gly Pro Ile Phe Asp Tyr Asp Tyr Asp Gly Leu His Asp 
785                 790                 795                 800 


Thr Glu Asp Lys Ile Lys Gln Tyr Val Glu Gly Ser Ser Ile Pro Val 
                805                 810                 815     


Pro Thr His Tyr Tyr Ser Ile Ile Thr Ser Cys Leu Asp Phe Thr Gln 
            820                 825                 830         


Pro Ala Asp Lys Cys Asp Gly Pro Leu Ser Val Ser Ser Phe Ile Leu 
        835                 840                 845             


Pro His Arg Pro Asp Asn Glu Glu Ser Cys Asn Ser Ser Glu Asp Glu 
    850                 855                 860                 


Ser Lys Trp Val Glu Glu Leu Met Lys Met His Thr Ala Arg Val Arg 
865                 870                 875                 880 


Asp Ile Glu His Leu Thr Ser Leu Asp Phe Phe Arg Lys Thr Ser Arg 
                885                 890                 895     


Ser Tyr Pro Glu Ile Leu Thr Leu Lys Thr Tyr Leu His Thr Tyr Glu 
            900                 905                 910         


Ser Glu Ile 
        915 


<210>  3458
<211>  984
<212>  PRT
<213>  Homo sapiens

<400>  3458

Met Ala Ser Asn Pro Glu Arg Gly Glu Ile Leu Leu Thr Glu Leu Gln 
1               5                   10                  15      


Gly Asp Ser Arg Ser Leu Pro Phe Ser Glu Asn Val Ser Ala Val Gln 
            20                  25                  30          


Lys Leu Asp Phe Ser Asp Thr Met Val Gln Gln Lys Leu Asp Asp Ile 
        35                  40                  45              


Lys Asp Arg Ile Lys Arg Glu Ile Arg Lys Glu Leu Lys Ile Lys Glu 
    50                  55                  60                  


Gly Ala Glu Asn Leu Arg Lys Val Thr Thr Asp Lys Lys Ser Leu Ala 
65                  70                  75                  80  


Tyr Val Asp Asn Ile Leu Lys Lys Ser Asn Lys Lys Leu Glu Glu Leu 
                85                  90                  95      


His His Lys Leu Gln Glu Leu Asn Ala His Ile Val Val Ser Asp Pro 
            100                 105                 110         


Glu Asp Ile Thr Asp Cys Pro Arg Thr Pro Asp Thr Pro Asn Asn Asp 
        115                 120                 125             


Pro Arg Cys Ser Thr Ser Asn Asn Arg Leu Lys Ala Leu Gln Lys Gln 
    130                 135                 140                 


Leu Asp Ile Glu Leu Lys Val Lys Gln Gly Ala Glu Asn Met Ile Gln 
145                 150                 155                 160 


Met Tyr Ser Asn Gly Ser Ser Lys Asp Arg Lys Leu His Gly Thr Ala 
                165                 170                 175     


Gln Gln Leu Leu Gln Asp Ser Lys Thr Lys Ile Glu Val Ile Arg Met 
            180                 185                 190         


Gln Ile Leu Gln Ala Val Gln Thr Asn Glu Leu Ala Phe Asp Asn Ala 
        195                 200                 205             


Lys Pro Val Ile Ser Pro Leu Glu Leu Arg Met Glu Glu Leu Arg His 
    210                 215                 220                 


His Phe Arg Ile Glu Phe Ala Val Ala Glu Gly Ala Lys Asn Val Met 
225                 230                 235                 240 


Lys Leu Leu Gly Ser Gly Lys Val Thr Asp Arg Lys Ala Leu Ser Glu 
                245                 250                 255     


Ala Gln Ala Arg Phe Asn Glu Ser Ser Gln Lys Leu Asp Leu Leu Lys 
            260                 265                 270         


Tyr Ser Leu Glu Gln Arg Leu Asn Glu Val Pro Lys Asn His Pro Lys 
        275                 280                 285             


Ser Arg Ile Ile Ile Glu Glu Leu Ser Leu Val Ala Ala Ser Pro Thr 
    290                 295                 300                 


Leu Ser Pro Arg Gln Ser Met Ile Ser Thr Gln Asn Gln Tyr Ser Thr 
305                 310                 315                 320 


Leu Ser Lys Pro Ala Ala Leu Thr Gly Thr Leu Glu Val Arg Leu Met 
                325                 330                 335     


Gly Cys Gln Asp Ile Leu Glu Asn Val Pro Gly Arg Ser Lys Ala Thr 
            340                 345                 350         


Ser Val Ala Leu Pro Gly Trp Ser Pro Ser Glu Thr Arg Ser Ser Phe 
        355                 360                 365             


Met Ser Arg Thr Ser Lys Ser Lys Ser Gly Ser Ser Arg Asn Leu Leu 
    370                 375                 380                 


Lys Thr Asp Asp Leu Ser Asn Asp Val Cys Ala Val Leu Lys Leu Asp 
385                 390                 395                 400 


Asn Thr Val Val Gly Gln Thr Ser Trp Lys Pro Ile Ser Asn Gln Ser 
                405                 410                 415     


Trp Asp Gln Lys Phe Thr Leu Glu Leu Asp Arg Ser Arg Glu Leu Glu 
            420                 425                 430         


Ile Ser Val Tyr Trp Arg Asp Trp Arg Ser Leu Cys Ala Val Lys Phe 
        435                 440                 445             


Leu Arg Leu Glu Asp Phe Leu Asp Asn Gln Arg His Gly Met Cys Leu 
    450                 455                 460                 


Tyr Leu Glu Pro Gln Gly Thr Leu Phe Ala Glu Val Thr Phe Phe Asn 
465                 470                 475                 480 


Pro Val Ile Glu Arg Arg Pro Lys Leu Gln Arg Gln Lys Lys Ile Phe 
                485                 490                 495     


Ser Lys Gln Gln Gly Lys Thr Phe Leu Arg Ala Pro Gln Met Asn Ile 
            500                 505                 510         


Asn Ile Ala Thr Trp Gly Arg Leu Val Arg Arg Ala Ile Pro Thr Val 
        515                 520                 525             


Asn His Ser Gly Thr Phe Ser Pro Gln Ala Pro Val Pro Thr Thr Val 
    530                 535                 540                 


Pro Val Val Asp Val Arg Ile Pro Gln Leu Ala Pro Pro Ala Ser Asp 
545                 550                 555                 560 


Ser Thr Val Thr Lys Leu Asp Phe Asp Leu Glu Pro Glu Pro Pro Pro 
                565                 570                 575     


Ala Pro Pro Arg Ala Ser Ser Leu Gly Glu Ile Asp Glu Ser Ser Glu 
            580                 585                 590         


Leu Arg Val Leu Asp Ile Pro Gly Gln Asp Ser Glu Thr Val Phe Asp 
        595                 600                 605             


Ile Gln Asn Asp Arg Asn Ser Ile Leu Pro Lys Ser Gln Ser Glu Tyr 
    610                 615                 620                 


Lys Pro Asp Thr Pro Gln Ser Gly Leu Glu Tyr Ser Gly Ile Gln Glu 
625                 630                 635                 640 


Leu Glu Asp Arg Arg Ser Gln Gln Arg Phe Gln Phe Asn Leu Gln Asp 
                645                 650                 655     


Phe Arg Cys Cys Ala Val Leu Gly Arg Gly His Phe Gly Lys Val Leu 
            660                 665                 670         


Leu Ala Glu Tyr Lys Asn Thr Asn Glu Met Phe Ala Ile Lys Ala Leu 
        675                 680                 685             


Lys Lys Gly Asp Ile Val Ala Arg Asp Glu Val Asp Ser Leu Met Cys 
    690                 695                 700                 


Glu Lys Arg Ile Phe Glu Thr Val Asn Ser Val Arg His Pro Phe Leu 
705                 710                 715                 720 


Val Asn Leu Phe Ala Cys Phe Gln Thr Lys Glu His Val Cys Phe Val 
                725                 730                 735     


Met Glu Tyr Ala Ala Gly Gly Asp Leu Met Met His Ile His Thr Asp 
            740                 745                 750         


Val Phe Ser Glu Pro Arg Ala Val Phe Tyr Ala Ala Cys Val Val Leu 
        755                 760                 765             


Gly Leu Gln Tyr Leu His Glu His Lys Ile Val Tyr Arg Asp Leu Lys 
    770                 775                 780                 


Leu Asp Asn Leu Leu Leu Asp Thr Glu Gly Phe Val Lys Ile Ala Asp 
785                 790                 795                 800 


Phe Gly Leu Cys Lys Glu Gly Met Gly Tyr Gly Asp Arg Thr Ser Thr 
                805                 810                 815     


Phe Cys Gly Thr Pro Glu Phe Leu Ala Pro Glu Val Leu Thr Glu Thr 
            820                 825                 830         


Ser Tyr Thr Arg Ala Val Asp Trp Trp Gly Leu Gly Val Leu Ile Tyr 
        835                 840                 845             


Glu Met Leu Val Gly Glu Ser Pro Phe Pro Gly Asp Asp Glu Glu Glu 
    850                 855                 860                 


Val Phe Asp Ser Ile Val Asn Asp Glu Val Arg Tyr Pro Arg Phe Leu 
865                 870                 875                 880 


Ser Thr Glu Ala Ile Ser Ile Met Arg Arg Leu Leu Arg Arg Asn Pro 
                885                 890                 895     


Glu Arg Arg Leu Gly Ala Ser Glu Lys Asp Ala Glu Asp Val Lys Lys 
            900                 905                 910         


His Pro Phe Phe Arg Leu Ile Asp Trp Ser Ala Leu Met Asp Lys Lys 
        915                 920                 925             


Val Lys Pro Pro Phe Ile Pro Thr Ile Arg Gly Arg Glu Asp Val Ser 
    930                 935                 940                 


Asn Phe Asp Asp Glu Phe Thr Ser Glu Ala Pro Ile Leu Thr Pro Pro 
945                 950                 955                 960 


Arg Glu Pro Arg Ile Leu Ser Glu Glu Glu Gln Glu Met Phe Arg Asp 
                965                 970                 975     


Phe Asp Tyr Ile Ala Asp Trp Cys 
            980                 


<210>  3459
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  3459

Met Val Ser Lys Ser Arg Trp Lys Leu Leu Ala Met Leu Ala Leu Val 
1               5                   10                  15      


Leu Val Val Met Val Trp Tyr Ser Ile Ser Arg Glu Asp Ser Phe Tyr 
            20                  25                  30          


Phe Pro Ile Pro Glu Lys Lys Glu Pro Cys Leu Gln Gly Glu Ala Glu 
        35                  40                  45              


Ser Lys Ala Ser Lys Leu Phe Gly Asn Tyr Ser Arg Asp Gln Pro Ile 
    50                  55                  60                  


Phe Leu Arg Leu Glu Asp Tyr Phe Trp Val Lys Thr Pro Ser Ala Tyr 
65                  70                  75                  80  


Glu Leu Pro Tyr Gly Thr Lys Gly Ser Glu Asp Leu Leu Leu Arg Val 
                85                  90                  95      


Leu Ala Ile Thr Ser Ser Ser Ile Pro Lys Asn Ile Gln Ser Leu Arg 
            100                 105                 110         


Cys Arg Arg Cys Val Val Val Gly Asn Gly His Arg Leu Arg Asn Ser 
        115                 120                 125             


Ser Leu Gly Asp Ala Ile Asn Lys Tyr Asp Val Val Ile Arg Leu Asn 
    130                 135                 140                 


Asn Ala Pro Val Ala Gly Tyr Glu Gly Asp Val Gly Ser Lys Thr Thr 
145                 150                 155                 160 


Met Arg Leu Phe Tyr Pro Glu Ser Ala His Phe Asp Pro Lys Val Glu 
                165                 170                 175     


Asn Asn Pro Asp Thr Leu Leu Val Leu Val Ala Phe Lys Ala Met Asp 
            180                 185                 190         


Phe His Trp Ile Glu Thr Ile Leu Ser Asp Lys Lys Arg Val Arg Lys 
        195                 200                 205             


Gly Phe Trp Lys Gln Pro Pro Leu Ile Trp Asp Val Asn Pro Lys Gln 
    210                 215                 220                 


Ile Arg Ile Leu Asn Pro Phe Phe Met Glu Ile Ala Ala Asp Lys Leu 
225                 230                 235                 240 


Leu Ser Leu Pro Met Gln Gln Pro Arg Lys Ile Lys Gln Lys Pro Thr 
                245                 250                 255     


Thr Gly Leu Leu Ala Ile Thr Leu Ala Leu His Leu Cys Asp Leu Val 
            260                 265                 270         


His Ile Ala Gly Phe Gly Tyr Pro Asp Ala Tyr Asn Lys Lys Gln Thr 
        275                 280                 285             


Ile His Tyr Tyr Glu Gln Ile Thr Leu Lys Ser Met Ala Gly Ser Gly 
    290                 295                 300                 


His Asn Val Ser Gln Glu Ala Leu Ala Ile Lys Arg Met Leu Glu Met 
305                 310                 315                 320 


Gly Ala Ile Lys Asn Leu Thr Ser Phe 
                325                 


<210>  3460
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  3460

Met Gly Leu Leu Val Phe Val Arg Asn Leu Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Phe Leu Val Leu Gly Phe Leu Tyr Tyr Ser Ala Trp Lys Leu His Leu 
            20                  25                  30          


Leu Gln Trp Glu Glu Asp Ser Asn Ser Val Val Leu Ser Phe Asp Ser 
        35                  40                  45              


Ala Gly Gln Thr Leu Gly Ser Glu Tyr Asp Arg Leu Gly Phe Leu Leu 
    50                  55                  60                  


Asn Leu Asp Ser Lys Leu Pro Ala Glu Leu Ala Thr Lys Tyr Ala Asn 
65                  70                  75                  80  


Phe Ser Glu Gly Ala Cys Lys Pro Gly Tyr Ala Ser Ala Leu Met Thr 
                85                  90                  95      


Ala Ile Phe Pro Arg Phe Ser Lys Pro Ala Pro Met Phe Leu Asp Asp 
            100                 105                 110         


Ser Phe Arg Lys Trp Ala Arg Ile Arg Glu Phe Val Pro Pro Phe Gly 
        115                 120                 125             


Ile Lys Gly Gln Asp Asn Leu Ile Lys Ala Ile Leu Ser Val Thr Lys 
    130                 135                 140                 


Glu Tyr Arg Leu Thr Pro Ala Leu Asp Ser Leu Arg Cys Arg Arg Cys 
145                 150                 155                 160 


Ile Ile Val Gly Asn Gly Gly Val Leu Ala Asn Lys Ser Leu Gly Ser 
                165                 170                 175     


Arg Ile Asp Asp Tyr Asp Ile Val Val Arg Leu Asn Ser Ala Pro Val 
            180                 185                 190         


Lys Gly Phe Glu Lys Asp Val Gly Ser Lys Thr Thr Leu Arg Ile Thr 
        195                 200                 205             


Tyr Pro Glu Gly Ala Met Gln Arg Pro Glu Gln Tyr Glu Arg Asp Ser 
    210                 215                 220                 


Leu Phe Val Leu Ala Gly Phe Lys Trp Gln Asp Phe Lys Trp Leu Lys 
225                 230                 235                 240 


Tyr Ile Val Tyr Lys Glu Arg Val Ser Ala Ser Asp Gly Phe Trp Lys 
                245                 250                 255     


Ser Val Ala Thr Arg Val Pro Lys Glu Pro Pro Glu Ile Arg Ile Leu 
            260                 265                 270         


Asn Pro Tyr Phe Ile Gln Glu Ala Ala Phe Thr Leu Ile Gly Leu Pro 
        275                 280                 285             


Phe Asn Asn Gly Leu Met Gly Arg Gly Asn Ile Pro Thr Leu Gly Ser 
    290                 295                 300                 


Val Ala Val Thr Met Ala Leu His Gly Cys Asp Glu Val Ala Val Ala 
305                 310                 315                 320 


Gly Phe Gly Tyr Asp Met Ser Thr Pro Asn Ala Pro Leu His Tyr Tyr 
                325                 330                 335     


Glu Thr Val Arg Met Ala Ala Ile Lys Glu Ser Trp Thr His Asn Ile 
            340                 345                 350         


Gln Arg Glu Lys Glu Phe Leu Arg Lys Leu Val Lys Ala Arg Val Ile 
        355                 360                 365             


Thr Asp Leu Ser Ser Gly Ile 
    370                 375 


<210>  3461
<211>  890
<212>  PRT
<213>  Homo sapiens

<400>  3461

Met Ala Leu Arg Arg Ser Met Gly Arg Pro Gly Leu Pro Pro Leu Pro 
1               5                   10                  15      


Leu Pro Pro Pro Pro Arg Leu Gly Leu Leu Leu Ala Ala Leu Ala Ser 
            20                  25                  30          


Leu Leu Leu Pro Glu Ser Ala Ala Ala Gly Leu Lys Leu Met Gly Ala 
        35                  40                  45              


Pro Val Lys Leu Thr Val Ser Gln Gly Gln Pro Val Lys Leu Asn Cys 
    50                  55                  60                  


Ser Val Glu Gly Met Glu Glu Pro Asp Ile Gln Trp Val Lys Asp Gly 
65                  70                  75                  80  


Ala Val Val Gln Asn Leu Asp Gln Leu Tyr Ile Pro Val Ser Glu Gln 
                85                  90                  95      


His Trp Ile Gly Phe Leu Ser Leu Lys Ser Val Glu Arg Ser Asp Ala 
            100                 105                 110         


Gly Arg Tyr Trp Cys Gln Val Glu Asp Gly Gly Glu Thr Glu Ile Ser 
        115                 120                 125             


Gln Pro Val Trp Leu Thr Val Glu Gly Val Pro Phe Phe Thr Val Glu 
    130                 135                 140                 


Pro Lys Asp Leu Ala Val Pro Pro Asn Ala Pro Phe Gln Leu Ser Cys 
145                 150                 155                 160 


Glu Ala Val Gly Pro Pro Glu Pro Val Thr Ile Val Trp Trp Arg Gly 
                165                 170                 175     


Thr Thr Lys Ile Gly Gly Pro Ala Pro Ser Pro Ser Val Leu Asn Val 
            180                 185                 190         


Thr Gly Val Thr Gln Ser Thr Met Phe Ser Cys Glu Ala His Asn Leu 
        195                 200                 205             


Lys Gly Leu Ala Ser Ser Arg Thr Ala Thr Val His Leu Gln Ala Leu 
    210                 215                 220                 


Pro Ala Ala Pro Phe Asn Ile Thr Val Thr Lys Leu Ser Ser Ser Asn 
225                 230                 235                 240 


Ala Ser Val Ala Trp Met Pro Gly Ala Asp Gly Arg Ala Leu Leu Gln 
                245                 250                 255     


Ser Cys Thr Val Gln Val Thr Gln Ala Pro Gly Gly Trp Glu Val Leu 
            260                 265                 270         


Ala Val Val Val Pro Val Pro Pro Phe Thr Cys Leu Leu Arg Asp Leu 
        275                 280                 285             


Val Pro Ala Thr Asn Tyr Ser Leu Arg Val Arg Cys Ala Asn Ala Leu 
    290                 295                 300                 


Gly Pro Ser Pro Tyr Ala Asp Trp Val Pro Phe Gln Thr Lys Gly Leu 
305                 310                 315                 320 


Ala Pro Ala Ser Ala Pro Gln Asn Leu His Ala Ile Arg Thr Asp Ser 
                325                 330                 335     


Gly Leu Ile Leu Glu Trp Glu Glu Val Ile Pro Glu Ala Pro Leu Glu 
            340                 345                 350         


Gly Pro Leu Gly Pro Tyr Lys Leu Ser Trp Val Gln Asp Asn Gly Thr 
        355                 360                 365             


Gln Asp Glu Leu Thr Val Glu Gly Thr Arg Ala Asn Leu Thr Gly Trp 
    370                 375                 380                 


Asp Pro Gln Lys Asp Leu Ile Val Arg Val Cys Val Ser Asn Ala Val 
385                 390                 395                 400 


Gly Cys Gly Pro Trp Ser Gln Pro Leu Val Val Ser Ser His Asp Arg 
                405                 410                 415     


Ala Gly Gln Gln Gly Pro Pro His Ser Arg Thr Ser Trp Val Pro Val 
            420                 425                 430         


Val Leu Gly Val Leu Thr Ala Leu Val Thr Ala Ala Ala Leu Ala Leu 
        435                 440                 445             


Ile Leu Leu Arg Lys Arg Arg Lys Glu Thr Arg Phe Gly Gln Ala Phe 
    450                 455                 460                 


Asp Ser Val Met Ala Arg Gly Glu Pro Ala Val His Phe Arg Ala Ala 
465                 470                 475                 480 


Arg Ser Phe Asn Arg Glu Arg Pro Glu Arg Ile Glu Ala Thr Leu Asp 
                485                 490                 495     


Ser Leu Gly Ile Ser Asp Glu Leu Lys Glu Lys Leu Glu Asp Val Leu 
            500                 505                 510         


Ile Pro Glu Gln Gln Phe Thr Leu Gly Arg Met Leu Gly Lys Gly Glu 
        515                 520                 525             


Phe Gly Ser Val Arg Glu Ala Gln Leu Lys Gln Glu Asp Gly Ser Phe 
    530                 535                 540                 


Val Lys Val Ala Val Lys Met Leu Lys Ala Asp Ile Ile Ala Ser Ser 
545                 550                 555                 560 


Asp Ile Glu Glu Phe Leu Arg Glu Ala Ala Cys Met Lys Glu Phe Asp 
                565                 570                 575     


His Pro His Val Ala Lys Leu Val Gly Val Ser Leu Arg Ser Arg Ala 
            580                 585                 590         


Lys Gly Arg Leu Pro Ile Pro Met Val Ile Leu Pro Phe Met Lys His 
        595                 600                 605             


Gly Asp Leu His Ala Phe Leu Leu Ala Ser Arg Ile Gly Glu Asn Pro 
    610                 615                 620                 


Phe Asn Leu Pro Leu Gln Thr Leu Ile Arg Phe Met Val Asp Ile Ala 
625                 630                 635                 640 


Cys Gly Met Glu Tyr Leu Ser Ser Arg Asn Phe Ile His Arg Asp Leu 
                645                 650                 655     


Ala Ala Arg Asn Cys Met Leu Ala Glu Asp Met Thr Val Cys Val Ala 
            660                 665                 670         


Asp Phe Gly Leu Ser Arg Lys Ile Tyr Ser Gly Asp Tyr Tyr Arg Gln 
        675                 680                 685             


Gly Cys Ala Ser Lys Leu Pro Val Lys Trp Leu Ala Leu Glu Ser Leu 
    690                 695                 700                 


Ala Asp Asn Leu Tyr Thr Val Gln Ser Asp Val Trp Ala Phe Gly Val 
705                 710                 715                 720 


Thr Met Trp Glu Ile Met Thr Arg Gly Gln Thr Pro Tyr Ala Gly Ile 
                725                 730                 735     


Glu Asn Ala Glu Ile Tyr Asn Tyr Leu Ile Gly Gly Asn Arg Leu Lys 
            740                 745                 750         


Gln Pro Pro Glu Cys Met Glu Asp Val Tyr Asp Leu Met Tyr Gln Cys 
        755                 760                 765             


Trp Ser Ala Asp Pro Lys Gln Arg Pro Ser Phe Thr Cys Leu Arg Met 
    770                 775                 780                 


Glu Leu Glu Asn Ile Leu Gly Gln Leu Ser Val Leu Ser Ala Ser Gln 
785                 790                 795                 800 


Asp Pro Leu Tyr Ile Asn Ile Glu Arg Ala Glu Glu Pro Thr Ala Gly 
                805                 810                 815     


Gly Ser Leu Glu Leu Pro Gly Arg Asp Gln Pro Tyr Ser Gly Ala Gly 
            820                 825                 830         


Asp Gly Ser Gly Met Gly Ala Val Gly Gly Thr Pro Ser Asp Cys Arg 
        835                 840                 845             


Tyr Ile Leu Thr Pro Gly Gly Leu Ala Glu Gln Pro Gly Gln Ala Glu 
    850                 855                 860                 


His Gln Pro Glu Ser Pro Leu Asn Glu Thr Gln Arg Leu Leu Leu Leu 
865                 870                 875                 880 


Gln Gln Gly Leu Leu Pro His Ser Ser Cys 
                885                 890 


<210>  3462
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  3462

Met Pro Pro Lys Arg Asn Glu Lys Tyr Lys Leu Pro Ile Pro Phe Pro 
1               5                   10                  15      


Glu Gly Lys Val Leu Asp Asp Met Glu Gly Asn Gln Trp Val Leu Gly 
            20                  25                  30          


Lys Lys Ile Gly Ser Gly Gly Phe Gly Leu Ile Tyr Leu Ala Phe Pro 
        35                  40                  45              


Thr Asn Lys Pro Glu Lys Asp Ala Arg His Val Val Lys Val Glu Tyr 
    50                  55                  60                  


Gln Glu Asn Gly Pro Leu Phe Ser Glu Leu Lys Phe Tyr Gln Arg Val 
65                  70                  75                  80  


Ala Lys Lys Asp Cys Ile Lys Lys Trp Ile Glu Arg Lys Gln Leu Asp 
                85                  90                  95      


Tyr Leu Gly Ile Pro Leu Phe Tyr Gly Ser Gly Leu Thr Glu Phe Lys 
            100                 105                 110         


Gly Arg Ser Tyr Arg Phe Met Val Met Glu Arg Leu Gly Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Ser Gly Gln Asn Gly Thr Phe Lys Lys Ser Thr Val Leu 
    130                 135                 140                 


Gln Leu Gly Ile Arg Met Leu Asp Val Leu Glu Tyr Ile His Glu Asn 
145                 150                 155                 160 


Glu Tyr Val His Gly Asp Ile Lys Ala Ala Asn Leu Leu Leu Gly Tyr 
                165                 170                 175     


Lys Asn Pro Asp Gln Val Tyr Leu Ala Asp Tyr Gly Leu Ser Tyr Arg 
            180                 185                 190         


Tyr Cys Pro Asn Gly Asn His Lys Gln Tyr Gln Glu Asn Pro Arg Lys 
        195                 200                 205             


Gly His Asn Gly Thr Ile Glu Phe Thr Ser Leu Asp Ala His Lys Gly 
    210                 215                 220                 


Val Ala Leu Ser Arg Arg Ser Asp Val Glu Ile Leu Gly Tyr Cys Met 
225                 230                 235                 240 


Leu Arg Trp Leu Cys Gly Lys Leu Pro Trp Glu Gln Asn Leu Lys Asp 
                245                 250                 255     


Pro Val Ala Val Gln Thr Ala Lys Thr Asn Leu Leu Asp Glu Leu Pro 
            260                 265                 270         


Gln Ser Val Leu Lys Trp Ala Pro Ser Gly Ser Ser Cys Cys Glu Ile 
        275                 280                 285             


Ala Gln Phe Leu Val Cys Ala His Ser Leu Ala Tyr Asp Glu Lys Pro 
    290                 295                 300                 


Asn Tyr Gln Ala Leu Lys Lys Ile Leu Asn Pro His Gly Ile Pro Leu 
305                 310                 315                 320 


Gly Pro Leu Asp Phe Ser Thr Lys Gly Gln Ser Ile Asn Val His Thr 
                325                 330                 335     


Pro Asn Ser Gln Lys Val Asp Ser Gln Lys Ala Ala Thr Lys Gln Val 
            340                 345                 350         


Asn Lys Ala His Asn Arg Leu Ile Glu Lys Lys Val His Ser Glu Arg 
        355                 360                 365             


Ser Ala Glu Ser Cys Ala Thr Trp Lys Val Gln Lys Glu Glu Lys Leu 
    370                 375                 380                 


Ile Gly Leu Met Asn Asn Glu Ala Ala Gln Glu Ser Thr Arg Arg Arg 
385                 390                 395                 400 


Gln Lys Tyr Gln Glu Ser Gln Glu Pro Leu Asn Glu Val Asn Ser Phe 
                405                 410                 415     


Pro Gln Lys Ile Ser Tyr Thr Gln Phe Pro Asn Ser Phe Tyr Glu Pro 
            420                 425                 430         


His Gln Asp Phe Thr Ser Pro Asp Ile Phe Lys Lys Ser Arg Ser Pro 
        435                 440                 445             


Ser Trp Tyr Lys Tyr Thr Ser Thr Val Ser Thr Gly Ile Thr Asp Leu 
    450                 455                 460                 


Glu Ser Ser Thr Gly Leu Trp Pro Thr Ile Ser Gln Phe Thr Leu Ser 
465                 470                 475                 480 


Glu Glu Thr Asn Ala Asp Val Tyr Tyr Tyr Arg Ile Ile Ile Pro Val 
                485                 490                 495     


Leu Leu Met Leu Val Phe Leu Ala Leu Phe Phe Leu 
            500                 505             


<210>  3463
<211>  837
<212>  PRT
<213>  Homo sapiens

<400>  3463

Met Ala Arg Gly Glu Arg Arg Arg Arg Ala Val Pro Ala Glu Gly Val 
1               5                   10                  15      


Arg Thr Ala Glu Arg Ala Ala Arg Gly Gly Pro Gly Arg Arg Asp Gly 
            20                  25                  30          


Arg Gly Gly Gly Pro Arg Ser Thr Ala Gly Gly Val Ala Leu Ala Val 
        35                  40                  45              


Val Val Leu Ser Leu Ala Leu Gly Met Ser Gly Arg Trp Val Leu Ala 
    50                  55                  60                  


Trp Tyr Arg Ala Arg Arg Ala Val Thr Leu His Ser Ala Pro Pro Val 
65                  70                  75                  80  


Leu Pro Ala Asp Ser Ser Ser Pro Ala Val Ala Pro Asp Leu Phe Trp 
                85                  90                  95      


Gly Thr Tyr Arg Pro His Val Tyr Phe Gly Met Lys Thr Arg Ser Pro 
            100                 105                 110         


Lys Pro Leu Leu Thr Gly Leu Met Trp Ala Gln Gln Gly Thr Thr Pro 
        115                 120                 125             


Gly Thr Pro Lys Leu Arg His Thr Cys Glu Gln Gly Asp Gly Val Gly 
    130                 135                 140                 


Pro Tyr Gly Trp Glu Phe His Asp Gly Leu Ser Phe Gly Arg Gln His 
145                 150                 155                 160 


Ile Gln Asp Gly Ala Leu Arg Leu Thr Thr Glu Phe Val Lys Arg Pro 
                165                 170                 175     


Gly Gly Gln His Gly Gly Asp Trp Ser Trp Arg Val Thr Val Glu Pro 
            180                 185                 190         


Gln Asp Ser Gly Thr Ser Ala Leu Pro Leu Val Ser Leu Phe Phe Tyr 
        195                 200                 205             


Val Val Thr Asp Gly Lys Glu Val Leu Leu Pro Glu Val Gly Ala Lys 
    210                 215                 220                 


Gly Gln Leu Lys Phe Ile Ser Gly His Thr Ser Glu Leu Gly Asp Phe 
225                 230                 235                 240 


Arg Phe Thr Leu Leu Pro Pro Thr Ser Pro Gly Asp Thr Ala Pro Lys 
                245                 250                 255     


Tyr Gly Ser Tyr Asn Val Phe Trp Thr Ser Asn Pro Gly Leu Pro Leu 
            260                 265                 270         


Leu Thr Glu Met Val Lys Ser Arg Leu Asn Ser Trp Phe Gln His Arg 
        275                 280                 285             


Pro Pro Gly Ala Pro Pro Glu Arg Tyr Leu Gly Leu Pro Gly Ser Leu 
    290                 295                 300                 


Lys Trp Glu Asp Arg Gly Pro Ser Gly Gln Gly Gln Gly Gln Phe Leu 
305                 310                 315                 320 


Ile Gln Gln Val Thr Leu Lys Ile Pro Ile Ser Ile Glu Phe Val Phe 
                325                 330                 335     


Glu Ser Gly Ser Ala Gln Ala Gly Gly Asn Gln Ala Leu Pro Arg Leu 
            340                 345                 350         


Ala Gly Ser Leu Leu Thr Gln Ala Leu Glu Ser His Ala Glu Gly Phe 
        355                 360                 365             


Arg Glu Arg Phe Glu Lys Thr Phe Gln Leu Lys Glu Lys Gly Leu Ser 
    370                 375                 380                 


Ser Gly Glu Gln Val Leu Gly Gln Ala Ala Leu Ser Gly Leu Leu Gly 
385                 390                 395                 400 


Gly Ile Gly Tyr Phe Tyr Gly Gln Gly Leu Val Leu Pro Asp Ile Gly 
                405                 410                 415     


Val Glu Gly Ser Glu Gln Lys Val Asp Pro Ala Leu Phe Pro Pro Val 
            420                 425                 430         


Pro Leu Phe Thr Ala Val Pro Ser Arg Ser Phe Phe Pro Arg Gly Phe 
        435                 440                 445             


Leu Trp Asp Glu Gly Phe His Gln Leu Val Val Gln Arg Trp Asp Pro 
    450                 455                 460                 


Ser Leu Thr Arg Glu Ala Leu Gly His Trp Leu Gly Leu Leu Asn Ala 
465                 470                 475                 480 


Asp Gly Trp Ile Gly Arg Glu Gln Ile Leu Gly Asp Glu Ala Arg Ala 
                485                 490                 495     


Arg Val Pro Pro Glu Phe Leu Val Gln Arg Ala Val His Ala Asn Pro 
            500                 505                 510         


Pro Thr Leu Leu Leu Pro Val Ala His Met Leu Glu Val Gly Asp Pro 
        515                 520                 525             


Asp Asp Leu Ala Phe Leu Arg Lys Ala Leu Pro Arg Leu His Ala Trp 
    530                 535                 540                 


Phe Ser Trp Leu His Gln Ser Gln Ala Gly Pro Leu Pro Leu Ser Tyr 
545                 550                 555                 560 


Arg Trp Arg Gly Arg Asp Pro Ala Leu Pro Thr Leu Leu Asn Pro Lys 
                565                 570                 575     


Thr Leu Pro Ser Gly Leu Asp Asp Tyr Pro Arg Ala Ser His Pro Ser 
            580                 585                 590         


Val Thr Glu Arg His Leu Asp Leu Arg Cys Trp Val Ala Leu Gly Ala 
        595                 600                 605             


Arg Val Leu Thr Arg Leu Ala Glu His Leu Gly Glu Ala Glu Val Ala 
    610                 615                 620                 


Ala Glu Leu Gly Pro Leu Ala Ala Ser Leu Glu Ala Ala Glu Ser Leu 
625                 630                 635                 640 


Asp Glu Leu His Trp Ala Pro Glu Leu Gly Val Phe Ala Asp Phe Gly 
                645                 650                 655     


Asn His Thr Lys Ala Val Gln Leu Lys Pro Arg Pro Pro Gln Gly Leu 
            660                 665                 670         


Val Arg Val Val Gly Arg Pro Gln Pro Gln Leu Gln Tyr Val Asp Ala 
        675                 680                 685             


Leu Gly Tyr Val Ser Leu Phe Pro Leu Leu Leu Arg Leu Leu Asp Pro 
    690                 695                 700                 


Thr Ser Ser Arg Leu Gly Pro Leu Leu Asp Ile Leu Ala Asp Ser Arg 
705                 710                 715                 720 


His Leu Trp Ser Pro Phe Gly Leu Arg Ser Leu Ala Ala Ser Ser Ser 
                725                 730                 735     


Phe Tyr Gly Gln Arg Asn Ser Glu His Asp Pro Pro Tyr Trp Arg Gly 
            740                 745                 750         


Ala Val Trp Leu Asn Val Asn Tyr Leu Ala Leu Gly Ala Leu His His 
        755                 760                 765             


Tyr Gly His Leu Glu Gly Pro His Gln Ala Arg Ala Ala Lys Leu His 
    770                 775                 780                 


Gly Glu Leu Arg Ala Asn Val Val Gly Asn Val Trp Arg Gln Tyr Gln 
785                 790                 795                 800 


Ala Thr Gly Phe Leu Trp Glu Gln Tyr Ser Asp Arg Asp Gly Arg Gly 
                805                 810                 815     


Met Gly Cys Arg Pro Phe His Gly Trp Thr Ser Leu Val Leu Leu Ala 
            820                 825                 830         


Met Ala Glu Asp Tyr 
        835         


<210>  3464
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  3464

Met Leu Thr Arg Lys Ile Lys Leu Trp Asp Ile Asn Ala His Ile Thr 
1               5                   10                  15      


Cys Arg Leu Cys Ser Gly Tyr Leu Ile Asp Ala Thr Thr Val Thr Glu 
            20                  25                  30          


Cys Leu His Thr Phe Cys Arg Ser Cys Leu Val Lys Tyr Leu Glu Glu 
        35                  40                  45              


Asn Asn Thr Cys Pro Thr Cys Arg Ile Val Ile His Gln Ser His Pro 
    50                  55                  60                  


Leu Gln Tyr Ile Gly His Asp Arg Thr Met Gln Asp Ile Val Tyr Lys 
65                  70                  75                  80  


Leu Val Pro Gly Leu Gln Glu Ala Glu Met Arg Lys Gln Arg Glu Phe 
                85                  90                  95      


Tyr His Lys Leu Gly Met Glu Val Pro Gly Asp Ile Lys Gly Glu Thr 
            100                 105                 110         


Cys Ser Ala Lys Gln His Leu Asp Ser His Arg Asn Gly Glu Thr Lys 
        115                 120                 125             


Ala Asp Asp Ser Ser Asn Lys Glu Ala Ala Glu Glu Lys Pro Glu Glu 
    130                 135                 140                 


Asp Asn Asp Tyr His Arg Ser Asp Glu Gln Val Ser Ile Cys Leu Glu 
145                 150                 155                 160 


Cys Asn Ser Ser Lys Leu Arg Gly Leu Lys Arg Lys Trp Ile Arg Cys 
                165                 170                 175     


Ser Ala Gln Ala Thr Val Leu His Leu Lys Lys Phe Ile Ala Lys Lys 
            180                 185                 190         


Leu Asn Leu Ser Ser Phe Asn Glu Leu Asp Ile Leu Cys Asn Glu Glu 
        195                 200                 205             


Ile Leu Gly Lys Asp His Thr Leu Lys Phe Val Val Val Thr Arg Trp 
    210                 215                 220                 


Arg Phe Lys Lys Ala Pro Leu Leu Leu His Tyr Arg Pro Lys Met Asp 
225                 230                 235                 240 


Leu Leu 
        


<210>  3465
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  3465

Met Pro Asp Glu Asn Ile Phe Leu Phe Val Pro Asn Leu Ile Gly Tyr 
1               5                   10                  15      


Ala Arg Ile Val Phe Ala Ile Ile Ser Phe Tyr Phe Met Pro Cys Cys 
            20                  25                  30          


Pro Leu Thr Ala Ser Ser Phe Tyr Leu Leu Ser Gly Leu Leu Asp Ala 
        35                  40                  45              


Phe Asp Gly His Ala Ala Arg Ala Leu Asn Gln Gly Thr Arg Phe Gly 
    50                  55                  60                  


Ala Met Leu Asp Met Leu Thr Asp Arg Cys Ser Thr Met Cys Leu Leu 
65                  70                  75                  80  


Val Asn Leu Ala Leu Leu Tyr Pro Gly Ala Thr Leu Phe Phe Gln Ile 
                85                  90                  95      


Ser Met Ser Leu Asp Val Ala Ser His Trp Leu His Leu His Ser Ser 
            100                 105                 110         


Val Val Arg Gly Ser Glu Ser His Lys Met Ile Asp Leu Ser Gly Asn 
        115                 120                 125             


Pro Val Leu Arg Ile Tyr Tyr Thr Ser Arg Pro Ala Leu Phe Thr Leu 
    130                 135                 140                 


Cys Ala Gly Asn Glu Leu Phe Tyr Cys Leu Leu Tyr Leu Phe His Phe 
145                 150                 155                 160 


Ser Glu Gly Pro Leu Val Gly Ser Val Gly Leu Phe Arg Met Gly Leu 
                165                 170                 175     


Trp Val Thr Ala Pro Ile Ala Leu Leu Lys Ser Leu Ile Ser Val Ile 
            180                 185                 190         


His Leu Ile Thr Ala Ala Arg Asn Met Ala Ala Leu Asp Ala Ala Asp 
        195                 200                 205             


Arg Ala Lys Lys Lys 
    210             


<210>  3466
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  3466

Met Gly Gly Ala Gly Arg Gly Val Gly Glu Gly Arg Gly Arg Gly Gly 
1               5                   10                  15      


Gly Gly Arg Arg Trp Arg Ala Val Met Ala Ala Gly Asp Gly Asp Val 
            20                  25                  30          


Lys Leu Gly Thr Leu Gly Ser Gly Ser Glu Ser Ser Asn Asp Gly Gly 
        35                  40                  45              


Ser Glu Ser Pro Gly Asp Ala Gly Ala Ala Ala Glu Gly Gly Gly Trp 
    50                  55                  60                  


Ala Ala Ala Ala Leu Ala Leu Leu Thr Gly Gly Gly Glu Met Leu Leu 
65                  70                  75                  80  


Asn Val Ala Leu Val Ala Leu Val Leu Leu Gly Ala Tyr Arg Leu Trp 
                85                  90                  95      


Val Arg Trp Gly Arg Arg Gly Leu Gly Ala Gly Ala Gly Ala Gly Glu 
            100                 105                 110         


Glu Ser Pro Ala Thr Ser Leu Pro Arg Met Lys Lys Arg Asp Phe Ser 
        115                 120                 125             


Leu Glu Gln Leu Arg Gln Tyr Asp Gly Ser Arg Asn Pro Arg Ile Leu 
    130                 135                 140                 


Leu Ala Val Asn Gly Lys Val Phe Asp Val Thr Lys Gly Ser Lys Phe 
145                 150                 155                 160 


Tyr Gly Pro Ala Gly Pro Tyr Gly Ile Phe Ala Gly Arg Asp Ala Ser 
                165                 170                 175     


Arg Gly Leu Ala Thr Phe Cys Leu Asp Lys Asp Ala Leu Arg Asp Glu 
            180                 185                 190         


Tyr Asp Asp Leu Ser Asp Leu Asn Ala Val Gln Met Glu Ser Val Arg 
        195                 200                 205             


Glu Trp Glu Met Gln Phe Lys Glu Lys Tyr Asp Tyr Val Gly Arg Leu 
    210                 215                 220                 


Leu Lys Pro Gly Glu Glu Pro Ser Glu Tyr Thr Asp Glu Glu Asp Thr 
225                 230                 235                 240 


Lys Asp His Asn Lys Gln Asp 
                245         


<210>  3467
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  3467

Met Glu Gly Gly Gly Gly Ser Gly Asn Lys Thr Thr Gly Gly Leu Ala 
1               5                   10                  15      


Gly Phe Phe Gly Ala Gly Gly Ala Gly Tyr Ser His Ala Asp Leu Ala 
            20                  25                  30          


Gly Val Pro Leu Thr Gly Met Asn Pro Leu Ser Pro Tyr Leu Asn Val 
        35                  40                  45              


Asp Pro Arg Tyr Leu Val Gln Asp Thr Asp Glu Phe Ile Leu Pro Thr 
    50                  55                  60                  


Gly Ala Asn Lys Thr Arg Gly Arg Phe Glu Leu Ala Phe Phe Thr Ile 
65                  70                  75                  80  


Gly Gly Cys Cys Met Thr Gly Ala Ala Phe Gly Ala Met Asn Gly Leu 
                85                  90                  95      


Arg Leu Gly Leu Lys Glu Thr Gln Asn Met Ala Trp Ser Lys Pro Arg 
            100                 105                 110         


Asn Val Gln Ile Leu Asn Met Val Thr Arg Gln Gly Ala Leu Trp Ala 
        115                 120                 125             


Asn Thr Leu Gly Ser Leu Ala Leu Leu Tyr Ser Ala Phe Gly Val Ile 
    130                 135                 140                 


Ile Glu Lys Thr Arg Gly Ala Glu Asp Asp Leu Asn Thr Val Ala Ala 
145                 150                 155                 160 


Gly Thr Met Thr Gly Met Leu Tyr Lys Cys Thr Gly Gly Leu Arg Gly 
                165                 170                 175     


Ile Ala Arg Gly Gly Leu Thr Gly Leu Thr Leu Thr Ser Leu Tyr Ala 
            180                 185                 190         


Leu Tyr Asn Asn Trp Glu His Met Lys Gly Ser Leu Leu Gln Gln Ser 
        195                 200                 205             


Leu 
    


<210>  3468
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  3468

Met Cys Gly Asn Asn Met Ser Thr Pro Leu Pro Ala Ile Val Pro Ala 
1               5                   10                  15      


Ala Arg Lys Ala Thr Ala Ala Val Ile Phe Leu His Gly Leu Gly Asp 
            20                  25                  30          


Thr Gly His Gly Trp Ala Glu Ala Phe Ala Gly Ile Arg Ser Ser His 
        35                  40                  45              


Ile Lys Tyr Ile Cys Pro His Ala Pro Val Arg Pro Val Thr Leu Asn 
    50                  55                  60                  


Met Asn Val Ala Met Pro Ser Trp Phe Asp Ile Ile Gly Leu Ser Pro 
65                  70                  75                  80  


Asp Ser Gln Glu Asp Glu Ser Gly Ile Lys Gln Ala Ala Glu Asn Ile 
                85                  90                  95      


Lys Ala Leu Ile Asp Gln Glu Val Lys Asn Gly Ile Pro Ser Asn Arg 
            100                 105                 110         


Ile Ile Leu Gly Gly Phe Ser Gln Gly Gly Ala Leu Ser Leu Tyr Thr 
        115                 120                 125             


Ala Leu Thr Thr Gln Gln Lys Leu Ala Gly Val Thr Ala Leu Ser Cys 
    130                 135                 140                 


Trp Leu Pro Leu Arg Ala Ser Phe Pro Gln Gly Pro Ile Gly Gly Ala 
145                 150                 155                 160 


Asn Arg Asp Ile Ser Ile Leu Gln Cys His Gly Asp Cys Asp Pro Leu 
                165                 170                 175     


Val Pro Leu Met Phe Gly Ser Leu Thr Val Glu Lys Leu Lys Thr Leu 
            180                 185                 190         


Val Asn Pro Ala Asn Val Thr Phe Lys Thr Tyr Glu Gly Met Met His 
        195                 200                 205             


Ser Ser Cys Gln Gln Glu Met Met Asp Val Lys Gln Phe Ile Asp Lys 
    210                 215                 220                 


Leu Leu Pro Pro Ile Asp 
225                 230 


<210>  3469
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  3469

Met Glu Glu Tyr Ala Arg Glu Pro Cys Pro Trp Arg Ile Val Asp Asp 
1               5                   10                  15      


Cys Gly Gly Ala Phe Thr Met Gly Thr Ile Gly Gly Gly Ile Phe Gln 
            20                  25                  30          


Ala Ile Lys Gly Phe Arg Asn Ser Pro Val Gly Val Asn His Arg Leu 
        35                  40                  45              


Arg Gly Ser Leu Thr Ala Ile Lys Thr Arg Ala Pro Gln Leu Gly Gly 
    50                  55                  60                  


Ser Phe Ala Val Trp Gly Gly Leu Phe Ser Met Ile Asp Cys Ser Met 
65                  70                  75                  80  


Val Gln Val Arg Gly Lys Glu Asp Pro Trp Asn Ser Ile Thr Ser Gly 
                85                  90                  95      


Ala Leu Thr Gly Ala Ile Leu Ala Ala Arg Asn Gly Pro Val Ala Met 
            100                 105                 110         


Val Gly Ser Ala Ala Met Gly Gly Ile Leu Leu Ala Leu Ile Glu Gly 
        115                 120                 125             


Ala Gly Ile Leu Leu Thr Arg Phe Ala Ser Ala Gln Phe Pro Asn Gly 
    130                 135                 140                 


Pro Gln Phe Ala Glu Asp Pro Ser Gln Leu Pro Ser Thr Gln Leu Pro 
145                 150                 155                 160 


Ser Ser Pro Phe Gly Asp Tyr Arg Gln Tyr Gln 
                165                 170     


<210>  3470
<211>  713
<212>  PRT
<213>  Homo sapiens

<400>  3470

Met Arg Leu Leu Val Ala Pro Leu Leu Leu Ala Trp Val Ala Gly Ala 
1               5                   10                  15      


Thr Ala Ala Val Pro Val Val Pro Trp His Val Pro Cys Pro Pro Gln 
            20                  25                  30          


Cys Ala Cys Gln Ile Arg Pro Trp Tyr Thr Pro Arg Ser Ser Tyr Arg 
        35                  40                  45              


Glu Ala Thr Thr Val Asp Cys Asn Asp Leu Phe Leu Thr Ala Val Pro 
    50                  55                  60                  


Pro Ala Leu Pro Ala Gly Thr Gln Thr Leu Leu Leu Gln Ser Asn Ser 
65                  70                  75                  80  


Ile Val Arg Val Asp Gln Ser Glu Leu Gly Tyr Leu Ala Asn Leu Thr 
                85                  90                  95      


Glu Leu Asp Leu Ser Gln Asn Ser Phe Ser Asp Ala Arg Asp Cys Asp 
            100                 105                 110         


Phe His Ala Leu Pro Gln Leu Leu Ser Leu His Leu Glu Glu Asn Gln 
        115                 120                 125             


Leu Thr Arg Leu Glu Asp His Ser Phe Ala Gly Leu Ala Ser Leu Gln 
    130                 135                 140                 


Glu Leu Tyr Leu Asn His Asn Gln Leu Tyr Arg Ile Ala Pro Arg Ala 
145                 150                 155                 160 


Phe Ser Gly Leu Ser Asn Leu Leu Arg Leu His Leu Asn Ser Asn Leu 
                165                 170                 175     


Leu Arg Ala Ile Asp Ser Arg Trp Phe Glu Met Leu Pro Asn Leu Glu 
            180                 185                 190         


Ile Leu Met Ile Gly Gly Asn Lys Val Asp Ala Ile Leu Asp Met Asn 
        195                 200                 205             


Phe Arg Pro Leu Ala Asn Leu Arg Ser Leu Val Leu Ala Gly Met Asn 
    210                 215                 220                 


Leu Arg Glu Ile Ser Asp Tyr Ala Leu Glu Gly Leu Gln Ser Leu Glu 
225                 230                 235                 240 


Ser Leu Ser Phe Tyr Asp Asn Gln Leu Ala Arg Val Pro Arg Arg Ala 
                245                 250                 255     


Leu Glu Gln Val Pro Gly Leu Lys Phe Leu Asp Leu Asn Lys Asn Pro 
            260                 265                 270         


Leu Gln Arg Val Gly Pro Gly Asp Phe Ala Asn Met Leu His Leu Lys 
        275                 280                 285             


Glu Leu Gly Leu Asn Asn Met Glu Glu Leu Val Ser Ile Asp Lys Phe 
    290                 295                 300                 


Ala Leu Val Asn Leu Pro Glu Leu Thr Lys Leu Asp Ile Thr Asn Asn 
305                 310                 315                 320 


Pro Arg Leu Ser Phe Ile His Pro Arg Ala Phe His His Leu Pro Gln 
                325                 330                 335     


Met Glu Thr Leu Met Leu Asn Asn Asn Ala Leu Ser Ala Leu His Gln 
            340                 345                 350         


Gln Thr Val Glu Ser Leu Pro Asn Leu Gln Glu Val Gly Leu His Gly 
        355                 360                 365             


Asn Pro Ile Arg Cys Asp Cys Val Ile Arg Trp Ala Asn Ala Thr Gly 
    370                 375                 380                 


Thr Arg Val Arg Phe Ile Glu Pro Gln Ser Thr Leu Cys Ala Glu Pro 
385                 390                 395                 400 


Pro Asp Leu Gln Arg Leu Pro Val Arg Glu Val Pro Phe Arg Glu Met 
                405                 410                 415     


Thr Asp His Cys Leu Pro Leu Ile Ser Pro Arg Ser Phe Pro Pro Ser 
            420                 425                 430         


Leu Gln Val Ala Ser Gly Glu Ser Met Val Leu His Cys Arg Ala Leu 
        435                 440                 445             


Ala Glu Pro Glu Pro Glu Ile Tyr Trp Val Thr Pro Ala Gly Leu Arg 
    450                 455                 460                 


Leu Thr Pro Ala His Ala Gly Arg Arg Tyr Arg Val Tyr Pro Glu Gly 
465                 470                 475                 480 


Thr Leu Glu Leu Arg Arg Val Thr Ala Glu Glu Ala Gly Leu Tyr Thr 
                485                 490                 495     


Cys Val Ala Gln Asn Leu Val Gly Ala Asp Thr Lys Thr Val Ser Val 
            500                 505                 510         


Val Val Gly Arg Ala Leu Leu Gln Pro Gly Arg Asp Glu Gly Gln Gly 
        515                 520                 525             


Leu Glu Leu Arg Val Gln Glu Thr His Pro Tyr His Ile Leu Leu Ser 
    530                 535                 540                 


Trp Val Thr Pro Pro Asn Thr Val Ser Thr Asn Leu Thr Trp Ser Ser 
545                 550                 555                 560 


Ala Ser Ser Leu Arg Gly Gln Gly Ala Thr Ala Leu Ala Arg Leu Pro 
                565                 570                 575     


Arg Gly Thr His Ser Tyr Asn Ile Thr Arg Leu Leu Gln Ala Thr Glu 
            580                 585                 590         


Tyr Trp Ala Cys Leu Gln Val Ala Phe Ala Asp Ala His Thr Gln Leu 
        595                 600                 605             


Ala Cys Val Trp Ala Arg Thr Lys Glu Ala Thr Ser Cys His Arg Ala 
    610                 615                 620                 


Leu Gly Asp Arg Pro Gly Leu Ile Ala Ile Leu Ala Leu Ala Val Leu 
625                 630                 635                 640 


Leu Leu Ala Ala Gly Leu Ala Ala His Leu Gly Thr Gly Gln Pro Arg 
                645                 650                 655     


Lys Gly Val Gly Gly Arg Arg Pro Leu Pro Pro Ala Trp Ala Phe Trp 
            660                 665                 670         


Gly Trp Ser Ala Pro Ser Val Arg Val Val Ser Ala Pro Leu Val Leu 
        675                 680                 685             


Pro Trp Asn Pro Gly Arg Lys Leu Pro Arg Ser Ser Glu Gly Glu Thr 
    690                 695                 700                 


Leu Leu Pro Pro Leu Ser Gln Asn Ser 
705                 710             


<210>  3471
<211>  999
<212>  PRT
<213>  Homo sapiens

<400>  3471

Met Gly Pro Ala Pro Leu Pro Leu Leu Leu Gly Leu Phe Leu Pro Ala 
1               5                   10                  15      


Leu Trp Arg Arg Ala Ile Thr Glu Ala Arg Glu Glu Ala Lys Pro Tyr 
            20                  25                  30          


Pro Leu Phe Pro Gly Pro Phe Pro Gly Ser Leu Gln Thr Asp His Thr 
        35                  40                  45              


Pro Leu Leu Ser Leu Pro His Ala Ser Gly Tyr Gln Pro Ala Leu Met 
    50                  55                  60                  


Phe Ser Pro Thr Gln Pro Gly Arg Pro His Thr Gly Asn Val Ala Ile 
65                  70                  75                  80  


Pro Gln Val Thr Ser Val Glu Ser Lys Pro Leu Pro Pro Leu Ala Phe 
                85                  90                  95      


Lys His Thr Val Gly His Ile Ile Leu Ser Glu His Lys Gly Val Lys 
            100                 105                 110         


Phe Asn Cys Ser Ile Ser Val Pro Asn Ile Tyr Gln Asp Thr Thr Ile 
        115                 120                 125             


Ser Trp Trp Lys Asp Gly Lys Glu Leu Leu Gly Ala His His Ala Ile 
    130                 135                 140                 


Thr Gln Phe Tyr Pro Asp Asp Glu Val Thr Ala Ile Ile Ala Ser Phe 
145                 150                 155                 160 


Ser Ile Thr Ser Val Gln Arg Ser Asp Asn Gly Ser Tyr Ile Cys Lys 
                165                 170                 175     


Met Lys Ile Asn Asn Glu Glu Ile Val Ser Asp Pro Ile Tyr Ile Glu 
            180                 185                 190         


Val Gln Gly Leu Pro His Phe Thr Lys Gln Pro Glu Ser Met Asn Val 
        195                 200                 205             


Thr Arg Asn Thr Ala Phe Asn Leu Thr Cys Gln Ala Val Gly Pro Pro 
    210                 215                 220                 


Glu Pro Val Asn Ile Phe Trp Val Gln Asn Ser Ser Arg Val Asn Glu 
225                 230                 235                 240 


Gln Pro Glu Lys Ser Pro Ser Val Leu Thr Val Pro Gly Leu Thr Glu 
                245                 250                 255     


Met Ala Val Phe Ser Cys Glu Ala His Asn Asp Lys Gly Leu Thr Val 
            260                 265                 270         


Ser Lys Gly Val Gln Ile Asn Ile Lys Ala Ile Pro Ser Pro Pro Thr 
        275                 280                 285             


Glu Val Ser Ile Arg Asn Ser Thr Ala His Ser Ile Leu Ile Ser Trp 
    290                 295                 300                 


Val Pro Gly Phe Asp Gly Tyr Ser Pro Phe Arg Asn Cys Ser Ile Gln 
305                 310                 315                 320 


Val Lys Glu Ala Asp Pro Leu Ser Asn Gly Ser Val Met Ile Phe Asn 
                325                 330                 335     


Thr Ser Ala Leu Pro His Leu Tyr Gln Ile Lys Gln Leu Gln Ala Leu 
            340                 345                 350         


Ala Asn Tyr Ser Ile Gly Val Ser Cys Met Asn Glu Ile Gly Trp Ser 
        355                 360                 365             


Ala Val Ser Pro Trp Ile Leu Ala Ser Thr Thr Glu Gly Ala Pro Ser 
    370                 375                 380                 


Val Ala Pro Leu Asn Val Thr Val Phe Leu Asn Glu Ser Ser Asp Asn 
385                 390                 395                 400 


Val Asp Ile Arg Trp Met Lys Pro Pro Thr Lys Gln Gln Asp Gly Glu 
                405                 410                 415     


Leu Val Gly Tyr Arg Ile Ser His Val Trp Gln Ser Ala Gly Ile Ser 
            420                 425                 430         


Lys Glu Leu Leu Glu Glu Val Gly Gln Asn Gly Ser Arg Ala Arg Ile 
        435                 440                 445             


Ser Val Gln Val His Asn Ala Thr Cys Thr Val Arg Ile Ala Ala Val 
    450                 455                 460                 


Thr Arg Gly Gly Val Gly Pro Phe Ser Asp Pro Val Lys Ile Phe Ile 
465                 470                 475                 480 


Pro Ala His Gly Trp Val Asp Tyr Ala Pro Ser Ser Thr Pro Ala Pro 
                485                 490                 495     


Gly Asn Ala Asp Pro Val Leu Ile Ile Phe Gly Cys Phe Cys Gly Phe 
            500                 505                 510         


Ile Leu Ile Gly Leu Ile Leu Tyr Ile Ser Leu Ala Ile Arg Lys Arg 
        515                 520                 525             


Val Gln Glu Thr Lys Phe Gly Asn Ala Phe Thr Glu Glu Asp Ser Glu 
    530                 535                 540                 


Leu Val Val Asn Tyr Ile Ala Lys Lys Ser Phe Cys Arg Arg Ala Ile 
545                 550                 555                 560 


Glu Leu Thr Leu His Ser Leu Gly Val Ser Glu Glu Leu Gln Asn Lys 
                565                 570                 575     


Leu Glu Asp Val Val Ile Asp Arg Asn Leu Leu Ile Leu Gly Lys Ile 
            580                 585                 590         


Leu Gly Glu Gly Glu Phe Gly Ser Val Met Glu Gly Asn Leu Lys Gln 
        595                 600                 605             


Glu Asp Gly Thr Ser Leu Lys Val Ala Val Lys Thr Met Lys Leu Asp 
    610                 615                 620                 


Asn Ser Ser Gln Arg Glu Ile Glu Glu Phe Leu Ser Glu Ala Ala Cys 
625                 630                 635                 640 


Met Lys Asp Phe Ser His Pro Asn Val Ile Arg Leu Leu Gly Val Cys 
                645                 650                 655     


Ile Glu Met Ser Ser Gln Gly Ile Pro Lys Pro Met Val Ile Leu Pro 
            660                 665                 670         


Phe Met Lys Tyr Gly Asp Leu His Thr Tyr Leu Leu Tyr Ser Arg Leu 
        675                 680                 685             


Glu Thr Gly Pro Lys His Ile Pro Leu Gln Thr Leu Leu Lys Phe Met 
    690                 695                 700                 


Val Asp Ile Ala Leu Gly Met Glu Tyr Leu Ser Asn Arg Asn Phe Leu 
705                 710                 715                 720 


His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Arg Asp Asp Met Thr 
                725                 730                 735     


Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Ser Gly Asp 
            740                 745                 750         


Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala 
        755                 760                 765             


Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp 
    770                 775                 780                 


Ala Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg Gly Met Thr Pro 
785                 790                 795                 800 


Tyr Pro Gly Val Gln Asn His Glu Met Tyr Asp Tyr Leu Leu His Gly 
                805                 810                 815     


His Arg Leu Lys Gln Pro Glu Asp Cys Leu Asp Glu Leu Tyr Glu Ile 
            820                 825                 830         


Met Tyr Ser Cys Trp Arg Thr Asp Pro Leu Asp Arg Pro Thr Phe Ser 
        835                 840                 845             


Val Leu Arg Leu Gln Leu Glu Lys Leu Leu Glu Ser Leu Pro Asp Val 
    850                 855                 860                 


Arg Asn Gln Ala Asp Val Ile Tyr Val Asn Thr Gln Leu Leu Glu Ser 
865                 870                 875                 880 


Ser Glu Gly Leu Ala Gln Gly Ser Thr Leu Ala Pro Leu Asp Leu Asn 
                885                 890                 895     


Ile Asp Pro Asp Ser Ile Ile Ala Ser Cys Thr Pro Arg Ala Ala Ile 
            900                 905                 910         


Ser Val Val Thr Ala Glu Val His Asp Ser Lys Pro His Glu Gly Arg 
        915                 920                 925             


Tyr Ile Leu Asn Gly Gly Ser Glu Glu Trp Glu Asp Leu Thr Ser Ala 
    930                 935                 940                 


Pro Ser Ala Ala Val Thr Ala Glu Lys Asn Ser Val Leu Pro Gly Glu 
945                 950                 955                 960 


Arg Leu Val Arg Asn Gly Val Ser Trp Ser His Ser Ser Met Leu Pro 
                965                 970                 975     


Leu Gly Ser Ser Leu Pro Asp Glu Leu Leu Phe Ala Asp Asp Ser Ser 
            980                 985                 990         


Glu Gly Ser Glu Val Leu Met 
        995                 


<210>  3472
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  3472

Met Thr Arg Thr Tyr Glu Asn Phe Gln Tyr Leu Glu Asn Lys Val Lys 
1               5                   10                  15      


Val Gln Gly Phe Lys Asn Gly Pro Leu Pro Leu Gln Ser Leu Leu Gln 
            20                  25                  30          


Arg Leu Cys Ser Gly Pro Cys His Leu Leu Leu Ser Leu Gly Leu Gly 
        35                  40                  45              


Leu Leu Leu Leu Val Ile Ile Cys Val Val Gly Phe Gln Asn Ser Lys 
    50                  55                  60                  


Phe Gln Arg Asp Leu Val Thr Leu Arg Thr Asp Phe Ser Asn Phe Thr 
65                  70                  75                  80  


Ser Asn Thr Val Ala Glu Ile Gln Ala Leu Thr Ser Gln Gly Ser Ser 
                85                  90                  95      


Leu Glu Glu Thr Ile Ala Ser Leu Lys Ala Glu Val Glu Gly Phe Lys 
            100                 105                 110         


Gln Glu Arg Gln Ala Val His Ser Glu Met Leu Leu Arg Val Gln Gln 
        115                 120                 125             


Leu Val Gln Asp Leu Lys Lys Leu Thr Cys Gln Val Ala Thr Leu Asn 
    130                 135                 140                 


Asn Asn Gly Glu Glu Ala Ser Thr Glu Gly Thr Cys Cys Pro Val Asn 
145                 150                 155                 160 


Trp Val Glu His Gln Asp Ser Cys Tyr Trp Phe Ser His Ser Gly Met 
                165                 170                 175     


Ser Trp Ala Glu Ala Glu Lys Tyr Cys Gln Leu Lys Asn Ala His Leu 
            180                 185                 190         


Val Val Ile Asn Ser Arg Glu Glu Gln Asn Phe Val Gln Lys Tyr Leu 
        195                 200                 205             


Gly Ser Ala Tyr Thr Trp Met Gly Leu Ser Asp Pro Glu Gly Ala Trp 
    210                 215                 220                 


Lys Trp Val Asp Gly Thr Asp Tyr Ala Thr Gly Phe Gln Asn Trp Lys 
225                 230                 235                 240 


Pro Gly Gln Pro Asp Asp Trp Gln Gly His Gly Leu Gly Gly Gly Glu 
                245                 250                 255     


Asp Cys Ala His Phe His Pro Asp Gly Arg Trp Asn Asp Asp Val Cys 
            260                 265                 270         


Gln Arg Pro Tyr His Trp Val Cys Glu Ala Gly Leu Gly Gln Thr Ser 
        275                 280                 285             


Gln Glu Ser His 
    290         


<210>  3473
<211>  568
<212>  PRT
<213>  Homo sapiens

<400>  3473

Met Leu Pro Gly Leu Ala Ala Ala Ala Ala His Arg Cys Ser Trp Ser 
1               5                   10                  15      


Ser Leu Cys Arg Leu Arg Leu Arg Cys Arg Ala Ala Ala Cys Asn Pro 
            20                  25                  30          


Ser Asp Arg Gln Glu Trp Gln Asn Leu Val Thr Phe Gly Ser Phe Ser 
        35                  40                  45              


Asn Met Val Pro Cys Ser His Pro Tyr Ile Gly Thr Leu Ser Gln Val 
    50                  55                  60                  


Lys Leu Tyr Ser Thr Asn Val Gln Lys Glu Gly Gln Gly Ser Gln Thr 
65                  70                  75                  80  


Leu Arg Val Glu Lys Val Pro Ser Phe Glu Thr Ala Glu Gly Ile Gly 
                85                  90                  95      


Thr Glu Leu Lys Ala Pro Leu Lys Gln Glu Pro Leu Gln Val Arg Val 
            100                 105                 110         


Lys Ala Val Leu Lys Lys Arg Glu Tyr Gly Ser Lys Tyr Thr Gln Asn 
        115                 120                 125             


Asn Phe Ile Thr Gly Val Arg Ala Ile Asn Glu Phe Cys Leu Lys Ser 
    130                 135                 140                 


Ser Asp Leu Glu Gln Leu Arg Lys Ile Arg Arg Arg Ser Pro His Glu 
145                 150                 155                 160 


Asp Thr Glu Ser Phe Thr Val Tyr Leu Arg Ser Asp Val Glu Ala Lys 
                165                 170                 175     


Ser Leu Glu Val Trp Gly Ser Pro Glu Ala Leu Ala Arg Glu Lys Lys 
            180                 185                 190         


Leu Arg Lys Glu Ala Glu Ile Glu Tyr Arg Glu Arg Leu Phe Arg Asn 
        195                 200                 205             


Gln Lys Ile Leu Arg Glu Tyr Arg Asp Phe Leu Gly Asn Thr Lys Pro 
    210                 215                 220                 


Arg Ser Arg Thr Ala Ser Val Phe Phe Lys Gly Pro Gly Lys Val Val 
225                 230                 235                 240 


Met Val Ala Ile Cys Ile Asn Gly Leu Asn Cys Phe Phe Lys Phe Leu 
                245                 250                 255     


Ala Trp Ile Tyr Thr Gly Ser Ala Ser Met Phe Ser Glu Ala Ile His 
            260                 265                 270         


Ser Leu Ser Asp Thr Cys Asn Gln Gly Leu Leu Ala Leu Gly Ile Ser 
        275                 280                 285             


Lys Ser Val Gln Thr Pro Asp Pro Ser His Pro Tyr Gly Phe Ser Asn 
    290                 295                 300                 


Met Arg Tyr Ile Ser Ser Leu Ile Ser Gly Val Gly Ile Phe Met Met 
305                 310                 315                 320 


Gly Ala Gly Leu Ser Trp Tyr His Gly Val Met Gly Leu Leu His Pro 
                325                 330                 335     


Gln Pro Ile Glu Ser Leu Leu Trp Ala Tyr Cys Ile Leu Ala Gly Ser 
            340                 345                 350         


Leu Val Ser Glu Gly Ala Thr Leu Leu Val Ala Val Asn Glu Leu Arg 
        355                 360                 365             


Arg Asn Ala Arg Ala Lys Gly Met Ser Phe Tyr Lys Tyr Val Met Glu 
    370                 375                 380                 


Ser Arg Asp Pro Ser Thr Asn Val Ile Leu Leu Glu Asp Thr Ala Ala 
385                 390                 395                 400 


Val Leu Gly Val Ile Ile Ala Ala Thr Cys Met Gly Leu Thr Ser Ile 
                405                 410                 415     


Thr Gly Asn Pro Leu Tyr Asp Ser Leu Gly Ser Leu Gly Val Gly Thr 
            420                 425                 430         


Leu Leu Gly Met Val Ser Ala Phe Leu Ile Tyr Thr Asn Thr Glu Ala 
        435                 440                 445             


Leu Leu Gly Arg Ser Ile Gln Pro Glu Gln Val Gln Arg Leu Thr Glu 
    450                 455                 460                 


Leu Leu Glu Asn Asp Pro Ser Val Arg Ala Ile His Asp Val Lys Ala 
465                 470                 475                 480 


Thr Asp Leu Gly Leu Gly Lys Val Arg Phe Lys Ala Glu Val Asp Phe 
                485                 490                 495     


Asp Gly Arg Val Val Thr Arg Ser Tyr Leu Glu Lys Gln Asp Phe Asp 
            500                 505                 510         


Gln Met Leu Gln Glu Ile Gln Glu Val Lys Thr Pro Glu Glu Leu Glu 
        515                 520                 525             


Thr Phe Met Leu Lys His Gly Glu Asn Ile Ile Asp Thr Leu Gly Ala 
    530                 535                 540                 


Glu Val Asp Arg Leu Glu Lys Glu Leu Lys Lys Arg Asn Pro Glu Val 
545                 550                 555                 560 


Arg His Val Asp Leu Glu Ile Leu 
                565             


<210>  3474
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  3474

Met Ala Ser Val Leu Ser Tyr Glu Ser Leu Val His Ala Val Ala Gly 
1               5                   10                  15      


Ala Val Gly Ser Val Thr Ala Met Thr Val Phe Phe Pro Leu Asp Thr 
            20                  25                  30          


Ala Arg Leu Arg Leu Gln Val Asp Glu Lys Arg Lys Ser Lys Thr Thr 
        35                  40                  45              


His Met Val Leu Leu Glu Ile Ile Lys Glu Glu Gly Leu Leu Ala Pro 
    50                  55                  60                  


Tyr Arg Gly Trp Phe Pro Val Ile Ser Ser Leu Cys Cys Ser Asn Phe 
65                  70                  75                  80  


Val Tyr Phe Tyr Thr Phe Asn Ser Leu Lys Ala Leu Trp Val Lys Gly 
                85                  90                  95      


Gln His Ser Thr Thr Gly Lys Asp Leu Val Val Gly Phe Val Ala Gly 
            100                 105                 110         


Val Val Asn Val Leu Leu Thr Thr Pro Leu Trp Val Val Asn Thr Arg 
        115                 120                 125             


Leu Lys Leu Gln Gly Ala Lys Phe Arg Asn Glu Asp Ile Val Pro Thr 
    130                 135                 140                 


Asn Tyr Lys Gly Ile Ile Asp Ala Phe His Gln Ile Ile Arg Asp Glu 
145                 150                 155                 160 


Gly Ile Ser Ala Leu Trp Asn Gly Thr Phe Pro Ser Leu Leu Leu Val 
                165                 170                 175     


Phe Asn Pro Ala Ile Gln Phe Met Phe Tyr Glu Gly Leu Lys Arg Gln 
            180                 185                 190         


Leu Leu Lys Lys Arg Met Lys Leu Ser Ser Leu Asp Val Phe Ile Ile 
        195                 200                 205             


Gly Ala Val Ala Lys Ala Ile Ala Thr Thr Val Thr Tyr Pro Leu Gln 
    210                 215                 220                 


Thr Val Gln Ser Ile Leu Arg Phe Gly Arg His Arg Leu Asn Pro Glu 
225                 230                 235                 240 


Asn Arg Thr Leu Gly Ser Leu Arg Asn Ile Leu Tyr Leu Leu His Gln 
                245                 250                 255     


Arg Val Arg Arg Phe Gly Ile Met Gly Leu Tyr Lys Gly Leu Glu Ala 
            260                 265                 270         


Lys Leu Leu Gln Thr Val Leu Thr Ala Ala Leu Met Phe Leu Val Tyr 
        275                 280                 285             


Glu Lys Leu Thr Ala Ala Thr Phe Thr Val Met Gly Leu Lys Arg Ala 
    290                 295                 300                 


His Gln His 
305         


<210>  3475
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  3475

Met Ala Arg Arg Gly Trp Arg Arg Ala Pro Leu Arg Arg Gly Val Gly 
1               5                   10                  15      


Ser Ser Pro Arg Ala Arg Arg Leu Met Arg Pro Leu Trp Leu Leu Leu 
            20                  25                  30          


Ala Val Gly Val Phe Asp Trp Ala Gly Ala Ser Asp Gly Gly Gly Gly 
        35                  40                  45              


Glu Ala Arg Ala Met Asp Glu Glu Ile Val Ser Glu Lys Gln Ala Glu 
    50                  55                  60                  


Glu Ser His Arg Gln Asp Ser Ala Asn Leu Leu Ile Phe Ile Leu Leu 
65                  70                  75                  80  


Leu Thr Leu Thr Ile Leu Thr Ile Trp Leu Phe Lys His Arg Arg Ala 
                85                  90                  95      


Arg Phe Leu His Glu Thr Gly Leu Ala Met Ile Tyr Gly Leu Leu Val 
            100                 105                 110         


Gly Leu Val Leu Arg Tyr Gly Ile His Val Pro Ser Asp Val Asn Asn 
        115                 120                 125             


Val Thr Leu Ser Cys Glu Val Gln Ser Ser Pro Thr Thr Leu Leu Val 
    130                 135                 140                 


Thr Phe Asp Pro Glu Val Phe Phe Asn Ile Leu Leu Pro Pro Ile Ile 
145                 150                 155                 160 


Phe Tyr Ala Gly Tyr Ser Leu Lys Arg Arg His Phe Phe Arg Asn Leu 
                165                 170                 175     


Gly Ser Ile Leu Ala Tyr Ala Phe Leu Gly Thr Ala Ile Ser Cys Phe 
            180                 185                 190         


Val Ile Gly Ser Ile Met Tyr Gly Cys Val Thr Leu Met Lys Val Thr 
        195                 200                 205             


Gly Gln Leu Ala Gly Asp Phe Tyr Phe Thr Asp Cys Leu Leu Phe Gly 
    210                 215                 220                 


Ala Ile Val Ser Ala Thr Asp Pro Val Thr Val Leu Ala Ile Phe His 
225                 230                 235                 240 


Glu Leu Gln Val Asp Val Glu Leu Tyr Ala Leu Leu Phe Gly Glu Ser 
                245                 250                 255     


Val Leu Asn Asp Ala Val Ala Ile Val Leu Ser Ser Ser Ile Val Ala 
            260                 265                 270         


Tyr Gln Pro Ala Gly Asp Asn Ser His Thr Phe Asp Val Thr Ala Met 
        275                 280                 285             


Phe Lys Ser Ile Gly Ile Phe Leu Gly Ile Phe Ser Gly Ser Phe Ala 
    290                 295                 300                 


Met Gly Ala Ala Thr Gly Val Val Thr Ala Leu Val Thr Lys Phe Thr 
305                 310                 315                 320 


Lys Leu Arg Glu Phe Gln Leu Leu Glu Thr Gly Leu Phe Phe Leu Met 
                325                 330                 335     


Ser Trp Ser Thr Phe Leu Leu Ala Glu Ala Trp Gly Phe Thr Gly Val 
            340                 345                 350         


Val Ala Val Leu Phe Cys Gly Ile Thr Gln Ala His Tyr Thr Tyr Asn 
        355                 360                 365             


Asn Leu Ser Thr Glu Ser Gln His Arg Thr Lys Gln Leu Phe Glu Leu 
    370                 375                 380                 


Leu Asn Phe Leu Ala Glu Asn Phe Ile Phe Ser Tyr Met Gly Leu Thr 
385                 390                 395                 400 


Leu Phe Thr Phe Gln Asn His Val Phe Asn Pro Thr Phe Val Val Gly 
                405                 410                 415     


Ala Phe Val Ala Ile Phe Leu Gly Arg Ala Ala Asn Ile Tyr Pro Leu 
            420                 425                 430         


Ser Leu Leu Leu Asn Leu Gly Arg Arg Ser Lys Ile Gly Ser Asn Phe 
        435                 440                 445             


Gln His Met Met Met Phe Ala Gly Leu Arg Gly Ala Met Ala Phe Ala 
    450                 455                 460                 


Leu Ala Ile Arg Asp Thr Ala Thr Tyr Ala Arg Gln Met Met Phe Ser 
465                 470                 475                 480 


Thr Thr Leu Leu Ile Val Phe Phe Thr Val Trp Val Phe Gly Gly Gly 
                485                 490                 495     


Thr Thr Ala Met Leu Ser Cys Leu His Ile Arg Val Gly Val Asp Ser 
            500                 505                 510         


Asp Gln Glu His Leu Gly Val Pro Glu Asn Glu Arg Arg Thr Thr Lys 
        515                 520                 525             


Ala Glu Ser Ala Trp Leu Phe Arg Met Trp Tyr Asn Phe Asp His Asn 
    530                 535                 540                 


Tyr Leu Lys Pro Leu Leu Thr His Ser Gly Pro Pro Leu Thr Thr Thr 
545                 550                 555                 560 


Leu Pro Ala Cys Cys Gly Pro Ile Ala Arg Cys Leu Thr Ser Pro Gln 
                565                 570                 575     


Ala Tyr Glu Asn Gln Glu Gln Leu Lys Asp Asp Asp Ser Asp Leu Ile 
            580                 585                 590         


Leu Asn Asp Gly Asp Ile Ser Leu Thr Tyr Gly Asp Ser Thr Val Asn 
        595                 600                 605             


Thr Glu Pro Ala Thr Ser Ser Ala Pro Arg Arg Phe Met Gly Asn Ser 
    610                 615                 620                 


Ser Glu Asp Ala Leu Asp Arg Glu Leu Ala Phe Gly Asp His Glu Leu 
625                 630                 635                 640 


Val Ile Arg Gly Thr Arg Leu Val Leu Pro Met Asp Asp Ser Glu Pro 
                645                 650                 655     


Pro Leu Asn Leu Leu Asp Asn Thr Arg His Gly Pro Ala 
            660                 665                 


<210>  3476
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  3476

Met Ala Ser Ser Ala Ala Ser Ser Glu His Phe Glu Lys Leu His Glu 
1               5                   10                  15      


Ile Phe Arg Gly Leu His Glu Asp Leu Gln Gly Val Pro Glu Arg Leu 
            20                  25                  30          


Leu Gly Thr Ala Gly Thr Glu Glu Lys Lys Lys Leu Ile Arg Asp Phe 
        35                  40                  45              


Asp Glu Lys Gln Gln Glu Ala Asn Glu Thr Leu Ala Glu Met Glu Glu 
    50                  55                  60                  


Glu Leu Arg Tyr Ala Pro Leu Ser Phe Arg Asn Pro Met Met Ser Lys 
65                  70                  75                  80  


Leu Arg Asn Tyr Arg Lys Asp Leu Ala Lys Leu His Arg Glu Val Arg 
                85                  90                  95      


Ser Thr Pro Leu Thr Ala Thr Pro Gly Gly Arg Gly Asp Met Lys Tyr 
            100                 105                 110         


Gly Ile Tyr Ala Val Glu Asn Glu His Met Asn Arg Leu Gln Ser Gln 
        115                 120                 125             


Arg Ala Met Leu Leu Gln Gly Thr Glu Ser Leu Asn Arg Ala Thr Gln 
    130                 135                 140                 


Ser Ile Glu Arg Ser His Arg Ile Ala Thr Glu Thr Asp Gln Ile Gly 
145                 150                 155                 160 


Ser Glu Ile Ile Glu Glu Leu Gly Glu Gln Arg Asp Gln Leu Glu Arg 
                165                 170                 175     


Thr Lys Ser Arg Leu Val Asn Thr Ser Glu Asn Leu Ser Lys Ser Arg 
            180                 185                 190         


Lys Ile Leu Arg Ser Met Ser Arg Lys Val Thr Thr Asn Lys Leu Leu 
        195                 200                 205             


Leu Ser Ile Ile Ile Leu Leu Glu Leu Ala Ile Leu Gly Gly Leu Val 
    210                 215                 220                 


Tyr Tyr Lys Phe Phe Arg Ser His 
225                 230         


<210>  3477
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  3477

Met Glu Pro Gly Arg Arg Gly Ala Ala Ala Leu Leu Ala Leu Leu Cys 
1               5                   10                  15      


Val Ala Cys Ala Leu Arg Ala Gly Arg Ala Gln Tyr Glu Arg Tyr Ser 
            20                  25                  30          


Phe Arg Ser Phe Pro Arg Asp Glu Leu Met Pro Leu Glu Ser Ala Tyr 
        35                  40                  45              


Arg His Ala Leu Asp Lys Tyr Ser Gly Glu His Trp Ala Glu Ser Val 
    50                  55                  60                  


Gly Tyr Leu Glu Ile Ser Leu Arg Leu His Arg Leu Leu Arg Asp Ser 
65                  70                  75                  80  


Glu Ala Phe Cys His Arg Asn Cys Ser Ala Ala Pro Gln Pro Glu Pro 
                85                  90                  95      


Ala Ala Gly Leu Ala Ser Tyr Pro Glu Leu Arg Leu Phe Gly Gly Leu 
            100                 105                 110         


Leu Arg Arg Ala His Cys Leu Lys Arg Cys Lys Gln Gly Leu Pro Ala 
        115                 120                 125             


Phe Arg Gln Ser Gln Pro Ser Arg Glu Val Leu Ala Asp Phe Gln Arg 
    130                 135                 140                 


Arg Glu Pro Tyr Lys Phe Leu Gln Phe Ala Tyr Phe Lys Ala Asn Asn 
145                 150                 155                 160 


Leu Pro Lys Ala Ile Ala Ala Ala His Thr Phe Leu Leu Lys His Pro 
                165                 170                 175     


Asp Asp Glu Met Met Lys Arg Asn Met Ala Tyr Tyr Lys Ser Leu Pro 
            180                 185                 190         


Gly Ala Glu Asp Tyr Ile Lys Asp Leu Glu Thr Lys Ser Tyr Glu Ser 
        195                 200                 205             


Leu Phe Ile Arg Ala Val Arg Ala Tyr Asn Gly Glu Asn Trp Arg Thr 
    210                 215                 220                 


Ser Ile Thr Asp Met Glu Leu Ala Leu Pro Asp Phe Phe Lys Ala Phe 
225                 230                 235                 240 


Tyr Glu Cys Leu Ala Ala Cys Glu Gly Ser Arg Glu Ile Lys Asp Phe 
                245                 250                 255     


Lys Asp Phe Tyr Leu Ser Ile Ala Asp His Tyr Val Glu Val Leu Glu 
            260                 265                 270         


Cys Lys Ile Gln Cys Glu Glu Asn Leu Thr Pro Val Ile Gly Gly Tyr 
        275                 280                 285             


Pro Val Glu Lys Phe Val Ala Thr Met Tyr His Tyr Leu Gln Phe Ala 
    290                 295                 300                 


Tyr Tyr Lys Leu Asn Asp Leu Lys Asn Ala Ala Pro Cys Ala Val Ser 
305                 310                 315                 320 


Tyr Leu Leu Phe Asp Gln Asn Asp Lys Val Met Gln Gln Asn Leu Val 
                325                 330                 335     


Tyr Tyr Gln Tyr His Arg Asp Thr Trp Gly Leu Ser Asp Glu His Phe 
            340                 345                 350         


Gln Pro Arg Pro Glu Ala Val Gln Phe Phe Asn Val Thr Thr Leu Gln 
        355                 360                 365             


Lys Glu Leu Tyr Asp Phe Ala Lys Glu Asn Ile Met Asp Asp Asp Glu 
    370                 375                 380                 


Gly Glu Val Val Glu Tyr Val Asp Asp Leu Leu Glu Leu Glu Glu Thr 
385                 390                 395                 400 


Ser 
    


<210>  3478
<211>  862
<212>  PRT
<213>  Homo sapiens

<400>  3478

Met Arg Met Cys Thr Pro Ile Arg Gly Leu Leu Met Ala Leu Ala Val 
1               5                   10                  15      


Met Phe Gly Thr Ala Met Ala Phe Ala Pro Ile Pro Arg Ile Thr Trp 
            20                  25                  30          


Glu His Arg Glu Val His Leu Val Gln Phe His Glu Pro Asp Ile Tyr 
        35                  40                  45              


Asn Tyr Ser Ala Leu Leu Leu Ser Glu Asp Lys Asp Thr Leu Tyr Ile 
    50                  55                  60                  


Gly Ala Arg Glu Ala Val Phe Ala Val Asn Ala Leu Asn Ile Ser Glu 
65                  70                  75                  80  


Lys Gln His Glu Val Tyr Trp Lys Val Ser Glu Asp Lys Lys Ala Lys 
                85                  90                  95      


Cys Ala Glu Lys Gly Lys Ser Lys Gln Thr Glu Cys Leu Asn Tyr Ile 
            100                 105                 110         


Arg Val Leu Gln Pro Leu Ser Ala Thr Ser Leu Tyr Val Cys Gly Thr 
        115                 120                 125             


Asn Ala Phe Gln Pro Ala Cys Asp His Leu Asn Leu Thr Ser Phe Lys 
    130                 135                 140                 


Phe Leu Gly Lys Asn Glu Asp Gly Lys Gly Arg Cys Pro Phe Asp Pro 
145                 150                 155                 160 


Ala His Ser Tyr Thr Ser Val Met Val Asp Gly Glu Leu Tyr Ser Gly 
                165                 170                 175     


Thr Ser Tyr Asn Phe Leu Gly Ser Glu Pro Ile Ile Ser Arg Asn Ser 
            180                 185                 190         


Ser His Ser Pro Leu Arg Thr Glu Tyr Ala Ile Pro Trp Leu Asn Glu 
        195                 200                 205             


Pro Ser Phe Val Phe Ala Asp Val Ile Arg Lys Ser Pro Asp Ser Pro 
    210                 215                 220                 


Asp Gly Glu Asp Asp Arg Val Tyr Phe Phe Phe Thr Glu Val Ser Val 
225                 230                 235                 240 


Glu Tyr Glu Phe Val Phe Arg Val Leu Ile Pro Arg Ile Ala Arg Val 
                245                 250                 255     


Cys Lys Gly Asp Gln Gly Gly Leu Arg Thr Leu Gln Lys Lys Trp Thr 
            260                 265                 270         


Ser Phe Leu Lys Ala Arg Leu Ile Cys Ser Arg Pro Asp Ser Gly Leu 
        275                 280                 285             


Val Phe Asn Val Leu Arg Asp Val Phe Val Leu Arg Ser Pro Gly Leu 
    290                 295                 300                 


Lys Val Pro Val Phe Tyr Ala Leu Phe Thr Pro Gln Leu Asn Asn Val 
305                 310                 315                 320 


Gly Leu Ser Ala Val Cys Ala Tyr Asn Leu Ser Thr Ala Glu Glu Val 
                325                 330                 335     


Phe Ser His Gly Lys Tyr Met Gln Ser Thr Thr Val Glu Gln Ser His 
            340                 345                 350         


Thr Lys Trp Val Arg Tyr Asn Gly Pro Val Pro Lys Pro Arg Pro Gly 
        355                 360                 365             


Ala Cys Ile Asp Ser Glu Ala Arg Ala Ala Asn Tyr Thr Ser Ser Leu 
    370                 375                 380                 


Asn Leu Pro Asp Lys Thr Leu Gln Phe Val Lys Asp His Pro Leu Met 
385                 390                 395                 400 


Asp Asp Ser Val Thr Pro Ile Asp Asn Arg Pro Arg Leu Ile Lys Lys 
                405                 410                 415     


Asp Val Asn Tyr Thr Gln Ile Val Val Asp Arg Thr Gln Ala Leu Asp 
            420                 425                 430         


Gly Thr Val Tyr Asp Val Met Phe Val Ser Thr Asp Arg Gly Ala Leu 
        435                 440                 445             


His Lys Ala Ile Ser Leu Glu His Ala Val His Ile Ile Glu Glu Thr 
    450                 455                 460                 


Gln Leu Phe Gln Asp Phe Glu Pro Val Gln Thr Leu Leu Leu Ser Ser 
465                 470                 475                 480 


Lys Lys Gly Asn Arg Phe Val Tyr Ala Gly Ser Asn Ser Gly Val Val 
                485                 490                 495     


Gln Ala Pro Leu Ala Phe Cys Gly Lys His Gly Thr Cys Glu Asp Cys 
            500                 505                 510         


Val Leu Ala Arg Asp Pro Tyr Cys Ala Trp Ser Pro Pro Thr Ala Thr 
        515                 520                 525             


Cys Val Ala Leu His Gln Thr Glu Ser Pro Ser Arg Gly Leu Ile Gln 
    530                 535                 540                 


Glu Met Ser Gly Asp Ala Ser Val Cys Pro Asp Lys Ser Lys Gly Ser 
545                 550                 555                 560 


Tyr Arg Gln His Phe Phe Lys His Gly Gly Thr Ala Glu Leu Lys Cys 
                565                 570                 575     


Ser Gln Lys Ser Asn Leu Ala Arg Val Phe Trp Lys Phe Gln Asn Gly 
            580                 585                 590         


Val Leu Lys Ala Glu Ser Pro Lys Tyr Gly Leu Met Gly Arg Lys Asn 
        595                 600                 605             


Leu Leu Ile Phe Asn Leu Ser Glu Gly Asp Ser Gly Val Tyr Gln Cys 
    610                 615                 620                 


Leu Ser Glu Glu Arg Val Lys Asn Lys Thr Val Phe Gln Val Val Ala 
625                 630                 635                 640 


Lys His Val Leu Glu Val Lys Val Val Pro Lys Pro Val Val Ala Pro 
                645                 650                 655     


Thr Leu Ser Val Val Gln Thr Glu Gly Ser Arg Ile Ala Thr Lys Val 
            660                 665                 670         


Leu Val Ala Ser Thr Gln Gly Ser Ser Pro Pro Thr Pro Ala Val Gln 
        675                 680                 685             


Ala Thr Ser Ser Gly Ala Ile Thr Leu Pro Pro Lys Pro Ala Pro Thr 
    690                 695                 700                 


Gly Thr Ser Cys Glu Pro Lys Ile Val Ile Asn Thr Val Pro Gln Leu 
705                 710                 715                 720 


His Ser Glu Lys Thr Met Tyr Leu Lys Ser Ser Asp Asn Arg Leu Leu 
                725                 730                 735     


Met Ser Leu Phe Leu Phe Phe Phe Val Leu Phe Leu Cys Leu Phe Phe 
            740                 745                 750         


Tyr Asn Cys Tyr Lys Gly Tyr Leu Pro Arg Gln Cys Leu Lys Phe Arg 
        755                 760                 765             


Ser Ala Leu Leu Ile Gly Lys Lys Lys Pro Lys Ser Asp Phe Cys Asp 
    770                 775                 780                 


Arg Glu Gln Ser Leu Lys Glu Thr Leu Val Glu Pro Gly Ser Phe Ser 
785                 790                 795                 800 


Gln Gln Asn Gly Glu His Pro Lys Pro Ala Leu Asp Thr Gly Tyr Glu 
                805                 810                 815     


Thr Glu Gln Asp Thr Ile Thr Ser Lys Val Pro Thr Asp Arg Glu Asp 
            820                 825                 830         


Ser Gln Arg Ile Asp Asp Leu Ser Ala Arg Asp Lys Pro Phe Asp Val 
        835                 840                 845             


Lys Cys Glu Leu Lys Phe Ala Asp Ser Asp Ala Asp Gly Asp 
    850                 855                 860         


<210>  3479
<211>  999
<212>  PRT
<213>  Homo sapiens

<400>  3479

Met Ala Asp Lys Val Arg Arg Gln Arg Pro Arg Arg Arg Val Cys Trp 
1               5                   10                  15      


Ala Leu Val Ala Val Leu Leu Ala Asp Leu Leu Ala Leu Ser Asp Thr 
            20                  25                  30          


Leu Ala Val Met Ser Val Asp Leu Gly Ser Glu Ser Met Lys Val Ala 
        35                  40                  45              


Ile Val Lys Pro Gly Val Pro Met Glu Ile Val Leu Asn Lys Glu Ser 
    50                  55                  60                  


Arg Arg Lys Thr Pro Val Ile Val Thr Leu Lys Glu Asn Glu Arg Phe 
65                  70                  75                  80  


Phe Gly Asp Ser Ala Ala Ser Met Ala Ile Lys Asn Pro Lys Ala Thr 
                85                  90                  95      


Leu Arg Tyr Phe Gln His Leu Leu Gly Lys Gln Ala Asp Asn Pro His 
            100                 105                 110         


Val Ala Leu Tyr Gln Ala Arg Phe Pro Glu His Glu Leu Thr Phe Asp 
        115                 120                 125             


Pro Gln Arg Gln Thr Val His Phe Gln Ile Ser Ser Gln Leu Gln Phe 
    130                 135                 140                 


Ser Pro Glu Glu Val Leu Gly Met Val Leu Asn Tyr Ser Arg Ser Leu 
145                 150                 155                 160 


Ala Glu Asp Phe Ala Glu Gln Pro Ile Lys Asp Ala Val Ile Thr Val 
                165                 170                 175     


Pro Val Phe Phe Asn Gln Ala Glu Arg Arg Ala Val Leu Gln Ala Ala 
            180                 185                 190         


Arg Met Ala Gly Leu Lys Val Leu Gln Leu Ile Asn Asp Asn Thr Ala 
        195                 200                 205             


Thr Ala Leu Ser Tyr Gly Val Phe Arg Arg Lys Asp Ile Asn Thr Thr 
    210                 215                 220                 


Ala Gln Asn Ile Met Phe Tyr Asp Met Gly Ser Gly Ser Thr Val Cys 
225                 230                 235                 240 


Thr Ile Val Thr Tyr Gln Met Val Lys Thr Lys Glu Ala Gly Met Gln 
                245                 250                 255     


Pro Gln Leu Gln Ile Arg Gly Val Gly Phe Asp Arg Thr Leu Gly Gly 
            260                 265                 270         


Leu Glu Met Glu Leu Arg Leu Arg Glu Arg Leu Ala Gly Leu Phe Asn 
        275                 280                 285             


Glu Gln Arg Lys Gly Gln Arg Ala Lys Asp Val Arg Glu Asn Pro Arg 
    290                 295                 300                 


Ala Met Ala Lys Leu Leu Arg Glu Ala Asn Arg Leu Lys Thr Val Leu 
305                 310                 315                 320 


Ser Ala Asn Ala Asp His Met Ala Gln Ile Glu Gly Leu Met Asp Asp 
                325                 330                 335     


Val Asp Phe Lys Ala Lys Val Thr Arg Val Glu Phe Glu Glu Leu Cys 
            340                 345                 350         


Ala Asp Leu Phe Glu Arg Val Pro Gly Pro Val Gln Gln Ala Leu Gln 
        355                 360                 365             


Ser Ala Glu Met Ser Leu Asp Glu Ile Glu Gln Val Ile Leu Val Gly 
    370                 375                 380                 


Gly Ala Thr Arg Val Pro Arg Val Gln Glu Val Leu Leu Lys Ala Val 
385                 390                 395                 400 


Gly Lys Glu Glu Leu Gly Lys Asn Ile Asn Ala Asp Glu Ala Ala Ala 
                405                 410                 415     


Met Gly Ala Val Tyr Gln Ala Ala Ala Leu Ser Lys Ala Phe Lys Val 
            420                 425                 430         


Lys Pro Phe Val Val Arg Asp Ala Val Val Tyr Pro Ile Leu Val Glu 
        435                 440                 445             


Phe Thr Arg Glu Val Glu Glu Glu Pro Gly Ile His Ser Leu Lys His 
    450                 455                 460                 


Asn Lys Arg Val Leu Phe Ser Arg Met Gly Pro Tyr Pro Gln Arg Lys 
465                 470                 475                 480 


Val Ile Thr Phe Asn Arg Tyr Ser His Asp Phe Asn Phe His Ile Asn 
                485                 490                 495     


Tyr Gly Asp Leu Gly Phe Leu Gly Pro Glu Asp Leu Arg Val Phe Gly 
            500                 505                 510         


Ser Gln Asn Leu Thr Thr Val Lys Leu Lys Gly Val Gly Asp Ser Phe 
        515                 520                 525             


Lys Lys Tyr Pro Asp Tyr Glu Ser Lys Gly Ile Lys Ala His Phe Asn 
    530                 535                 540                 


Leu Asp Glu Ser Gly Val Leu Ser Leu Asp Arg Val Glu Ser Val Phe 
545                 550                 555                 560 


Glu Thr Leu Val Glu Asp Ser Ala Glu Glu Glu Ser Thr Leu Thr Lys 
                565                 570                 575     


Leu Gly Asn Thr Ile Ser Ser Leu Phe Gly Gly Gly Thr Thr Pro Asp 
            580                 585                 590         


Ala Lys Glu Asn Gly Thr Asp Thr Val Gln Glu Glu Glu Glu Ser Pro 
        595                 600                 605             


Ala Glu Gly Ser Lys Asp Glu Pro Gly Glu Gln Val Glu Leu Lys Glu 
    610                 615                 620                 


Glu Ala Glu Ala Pro Val Glu Asp Gly Ser Gln Pro Pro Pro Pro Glu 
625                 630                 635                 640 


Pro Lys Gly Asp Ala Thr Pro Glu Gly Glu Lys Ala Thr Glu Lys Glu 
                645                 650                 655     


Asn Gly Asp Lys Ser Glu Ala Gln Lys Pro Ser Glu Lys Ala Glu Ala 
            660                 665                 670         


Gly Pro Glu Gly Val Ala Pro Ala Pro Glu Gly Glu Lys Lys Gln Lys 
        675                 680                 685             


Pro Ala Arg Lys Arg Arg Met Val Glu Glu Ile Gly Val Glu Leu Val 
    690                 695                 700                 


Val Leu Asp Leu Pro Asp Leu Pro Glu Asp Lys Leu Ala Gln Ser Val 
705                 710                 715                 720 


Gln Lys Leu Gln Asp Leu Thr Leu Arg Asp Leu Glu Lys Gln Glu Arg 
                725                 730                 735     


Glu Lys Ala Ala Asn Ser Leu Glu Ala Phe Ile Phe Glu Thr Gln Asp 
            740                 745                 750         


Lys Leu Tyr Gln Pro Glu Tyr Gln Glu Val Ser Thr Glu Glu Gln Arg 
        755                 760                 765             


Glu Glu Ile Ser Gly Lys Leu Ser Ala Ala Ser Thr Trp Leu Glu Asp 
    770                 775                 780                 


Glu Gly Val Gly Ala Thr Thr Val Met Leu Lys Glu Lys Leu Ala Glu 
785                 790                 795                 800 


Leu Arg Lys Leu Cys Gln Gly Leu Phe Phe Arg Val Glu Glu Arg Lys 
                805                 810                 815     


Lys Trp Pro Glu Arg Leu Ser Ala Leu Asp Asn Leu Leu Asn His Ser 
            820                 825                 830         


Ser Met Phe Leu Lys Gly Ala Arg Leu Ile Pro Glu Met Asp Gln Ile 
        835                 840                 845             


Phe Thr Glu Val Glu Met Thr Thr Leu Glu Lys Val Ile Asn Glu Thr 
    850                 855                 860                 


Trp Ala Trp Lys Asn Ala Thr Leu Ala Glu Gln Ala Lys Leu Pro Ala 
865                 870                 875                 880 


Thr Glu Lys Pro Val Leu Leu Ser Lys Asp Ile Glu Ala Lys Met Met 
                885                 890                 895     


Ala Leu Asp Arg Glu Val Gln Tyr Leu Leu Asn Lys Ala Lys Phe Thr 
            900                 905                 910         


Lys Pro Arg Pro Arg Pro Lys Asp Lys Asn Gly Thr Arg Ala Glu Pro 
        915                 920                 925             


Pro Leu Asn Ala Ser Ala Ser Asp Gln Gly Glu Lys Val Ile Pro Pro 
    930                 935                 940                 


Ala Gly Gln Thr Glu Asp Ala Glu Pro Ile Ser Glu Pro Glu Lys Val 
945                 950                 955                 960 


Glu Thr Gly Ser Glu Pro Gly Asp Thr Glu Pro Leu Glu Leu Gly Gly 
                965                 970                 975     


Pro Gly Ala Glu Pro Glu Gln Lys Glu Gln Ser Thr Gly Gln Lys Arg 
            980                 985                 990         


Pro Leu Lys Asn Asp Glu Leu 
        995                 


<210>  3480
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  3480

Met Leu Thr Thr Leu Leu Pro Ile Leu Leu Leu Ser Gly Trp Ala Phe 
1               5                   10                  15      


Cys Ser Gln Asp Ala Ser Asp Gly Leu Gln Arg Leu His Met Leu Gln 
            20                  25                  30          


Ile Ser Tyr Phe Arg Asp Pro Tyr His Val Trp Tyr Gln Gly Asn Ala 
        35                  40                  45              


Ser Leu Gly Gly His Leu Thr His Val Leu Glu Gly Pro Asp Thr Asn 
    50                  55                  60                  


Thr Thr Ile Ile Gln Leu Gln Pro Leu Gln Glu Pro Glu Ser Trp Ala 
65                  70                  75                  80  


Arg Thr Gln Ser Gly Leu Gln Ser Tyr Leu Leu Gln Phe His Gly Leu 
                85                  90                  95      


Val Arg Leu Val His Gln Glu Arg Thr Leu Ala Phe Pro Leu Thr Ile 
            100                 105                 110         


Arg Cys Phe Leu Gly Cys Glu Leu Pro Pro Glu Gly Ser Arg Ala His 
        115                 120                 125             


Val Phe Phe Glu Val Ala Val Asn Gly Ser Ser Phe Val Ser Phe Arg 
    130                 135                 140                 


Pro Glu Arg Ala Leu Trp Gln Ala Asp Thr Gln Val Thr Ser Gly Val 
145                 150                 155                 160 


Val Thr Phe Thr Leu Gln Gln Leu Asn Ala Tyr Asn Arg Thr Arg Tyr 
                165                 170                 175     


Glu Leu Arg Glu Phe Leu Glu Asp Thr Cys Val Gln Tyr Val Gln Lys 
            180                 185                 190         


His Ile Ser Ala Glu Asn Thr Lys Gly Ser Gln Thr Ser Arg Ser Tyr 
        195                 200                 205             


Thr Ser Leu Val Leu Gly Val Leu Val Gly Ser Phe Ile Ile Ala Gly 
    210                 215                 220                 


Val Ala Val Gly Ile Phe Leu Cys Thr Gly Gly Arg Arg Cys 
225                 230                 235             


<210>  3481
<211>  606
<212>  PRT
<213>  Homo sapiens

<400>  3481

Met Thr Val Val Gly Asn Pro Arg Ser Trp Ser Cys Gln Trp Leu Pro 
1               5                   10                  15      


Ile Leu Ile Leu Leu Leu Gly Thr Gly His Gly Pro Gly Val Glu Gly 
            20                  25                  30          


Val Thr His Tyr Lys Ala Gly Asp Pro Val Ile Leu Tyr Val Asn Lys 
        35                  40                  45              


Val Gly Pro Tyr His Asn Pro Gln Glu Thr Tyr His Tyr Tyr Gln Leu 
    50                  55                  60                  


Pro Val Cys Cys Pro Glu Lys Ile Arg His Lys Ser Leu Ser Leu Gly 
65                  70                  75                  80  


Glu Val Leu Asp Gly Asp Arg Met Ala Glu Ser Leu Tyr Glu Ile Arg 
                85                  90                  95      


Phe Arg Glu Asn Val Glu Lys Arg Ile Leu Cys His Met Gln Leu Ser 
            100                 105                 110         


Ser Ala Gln Val Glu Gln Leu Arg Gln Ala Ile Glu Glu Leu Tyr Tyr 
        115                 120                 125             


Phe Glu Phe Val Val Asp Asp Leu Pro Ile Arg Gly Phe Val Gly Tyr 
    130                 135                 140                 


Met Glu Glu Ser Gly Phe Leu Pro His Ser His Lys Ile Gly Leu Trp 
145                 150                 155                 160 


Thr His Leu Asp Phe His Leu Glu Phe His Gly Asp Arg Ile Ile Phe 
                165                 170                 175     


Ala Asn Val Ser Val Arg Asp Val Lys Pro His Ser Leu Asp Gly Leu 
            180                 185                 190         


Arg Pro Asp Glu Phe Leu Gly Leu Thr His Thr Tyr Ser Val Arg Trp 
        195                 200                 205             


Ser Glu Thr Ser Val Glu Arg Arg Ser Asp Arg Arg Arg Gly Asp Asp 
    210                 215                 220                 


Gly Gly Phe Phe Pro Arg Thr Leu Glu Ile His Trp Leu Ser Ile Ile 
225                 230                 235                 240 


Asn Ser Met Val Leu Val Phe Leu Leu Val Gly Phe Val Ala Val Ile 
                245                 250                 255     


Leu Met Arg Val Leu Arg Asn Asp Leu Ala Arg Tyr Asn Leu Asp Glu 
            260                 265                 270         


Glu Thr Thr Ser Ala Gly Ser Gly Asp Asp Phe Asp Gln Gly Asp Asn 
        275                 280                 285             


Gly Trp Lys Ile Ile His Thr Asp Val Phe Arg Phe Pro Pro Tyr Arg 
    290                 295                 300                 


Gly Leu Leu Cys Ala Val Leu Gly Val Gly Ala Gln Phe Leu Ala Leu 
305                 310                 315                 320 


Gly Thr Gly Ile Ile Val Met Ala Leu Leu Gly Met Phe Asn Val His 
                325                 330                 335     


Arg His Gly Ala Ile Asn Ser Ala Ala Ile Leu Leu Tyr Ala Leu Thr 
            340                 345                 350         


Cys Cys Ile Ser Gly Tyr Val Ser Ser His Phe Tyr Arg Gln Ile Gly 
        355                 360                 365             


Gly Glu Arg Trp Val Trp Asn Ile Ile Leu Thr Thr Ser Leu Phe Ser 
    370                 375                 380                 


Val Pro Phe Phe Leu Thr Trp Ser Val Val Asn Ser Val His Trp Ala 
385                 390                 395                 400 


Asn Gly Ser Thr Gln Ala Leu Pro Ala Thr Thr Ile Leu Leu Leu Leu 
                405                 410                 415     


Thr Val Trp Leu Leu Val Gly Phe Pro Leu Thr Val Ile Gly Gly Ile 
            420                 425                 430         


Phe Gly Lys Asn Asn Ala Ser Pro Phe Asp Ala Pro Cys Arg Thr Lys 
        435                 440                 445             


Asn Ile Ala Arg Glu Ile Pro Pro Gln Pro Trp Tyr Lys Ser Thr Val 
    450                 455                 460                 


Ile His Met Thr Val Gly Gly Phe Leu Pro Phe Ser Ala Ile Ser Val 
465                 470                 475                 480 


Glu Leu Tyr Tyr Ile Phe Ala Thr Val Trp Gly Arg Glu Gln Tyr Thr 
                485                 490                 495     


Leu Tyr Gly Ile Leu Phe Phe Val Phe Ala Ile Leu Leu Ser Val Gly 
            500                 505                 510         


Ala Cys Ile Ser Ile Ala Leu Thr Tyr Phe Gln Leu Ser Gly Glu Asp 
        515                 520                 525             


Tyr Arg Trp Trp Trp Arg Ser Val Leu Ser Val Gly Ser Thr Gly Leu 
    530                 535                 540                 


Phe Ile Phe Leu Tyr Ser Val Phe Tyr Tyr Ala Arg Arg Ser Asn Met 
545                 550                 555                 560 


Ser Gly Ala Val Gln Thr Val Glu Phe Phe Gly Tyr Ser Leu Leu Thr 
                565                 570                 575     


Gly Tyr Val Phe Phe Leu Met Leu Gly Thr Ile Ser Phe Phe Ser Ser 
            580                 585                 590         


Leu Lys Phe Ile Arg Tyr Ile Tyr Val Asn Leu Lys Met Asp 
        595                 600                 605     


<210>  3482
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  3482

Met Glu Ala Leu Pro Leu Leu Ala Ala Thr Thr Pro Asp His Gly Arg 
1               5                   10                  15      


His Arg Arg Leu Leu Leu Leu Pro Leu Leu Leu Phe Leu Leu Pro Ala 
            20                  25                  30          


Gly Ala Val Gln Gly Trp Glu Thr Glu Glu Arg Pro Arg Thr Arg Glu 
        35                  40                  45              


Glu Glu Cys His Phe Tyr Ala Gly Gly Gln Val Tyr Pro Gly Glu Ala 
    50                  55                  60                  


Ser Arg Val Ser Val Ala Asp His Ser Leu His Leu Ser Lys Ala Lys 
65                  70                  75                  80  


Ile Ser Lys Pro Ala Pro Tyr Trp Glu Gly Thr Ala Val Ile Asp Gly 
                85                  90                  95      


Glu Phe Lys Glu Leu Lys Leu Thr Asp Tyr Arg Gly Lys Tyr Leu Val 
            100                 105                 110         


Phe Phe Phe Tyr Pro Leu Asp Phe Thr Phe Val Cys Pro Thr Glu Ile 
        115                 120                 125             


Ile Ala Phe Gly Asp Arg Leu Glu Glu Phe Arg Ser Ile Asn Thr Glu 
    130                 135                 140                 


Val Val Ala Cys Ser Val Asp Ser Gln Phe Thr His Leu Ala Trp Ile 
145                 150                 155                 160 


Asn Thr Pro Arg Arg Gln Gly Gly Leu Gly Pro Ile Arg Ile Pro Leu 
                165                 170                 175     


Leu Ser Asp Leu Thr His Gln Ile Ser Lys Asp Tyr Gly Val Tyr Leu 
            180                 185                 190         


Glu Asp Ser Gly His Thr Leu Arg Gly Leu Phe Ile Ile Asp Asp Lys 
        195                 200                 205             


Gly Ile Leu Arg Gln Ile Thr Leu Asn Asp Leu Pro Val Gly Arg Ser 
    210                 215                 220                 


Val Asp Glu Thr Leu Arg Leu Val Gln Ala Phe Gln Tyr Thr Asp Lys 
225                 230                 235                 240 


His Gly Glu Val Cys Pro Ala Gly Trp Lys Pro Gly Ser Glu Thr Ile 
                245                 250                 255     


Ile Pro Asp Pro Ala Gly Lys Leu Lys Tyr Phe Asp Lys Leu Asn 
            260                 265                 270     


<210>  3483
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  3483

Met Asp Val Asn Ile Ala Pro Leu Arg Ala Trp Asp Asp Phe Phe Pro 
1               5                   10                  15      


Gly Ser Asp Arg Phe Ala Arg Pro Asp Phe Arg Asp Ile Ser Lys Trp 
            20                  25                  30          


Asn Asn Arg Val Val Ser Asn Leu Leu Tyr Tyr Gln Thr Asn Tyr Leu 
        35                  40                  45              


Val Val Ala Ala Met Met Ile Ser Ile Val Gly Phe Leu Ser Pro Phe 
    50                  55                  60                  


Asn Met Ile Leu Gly Gly Ile Val Val Val Leu Val Phe Thr Gly Phe 
65                  70                  75                  80  


Val Trp Ala Ala His Asn Lys Asp Val Leu Arg Arg Met Lys Lys Arg 
                85                  90                  95      


Tyr Pro Thr Thr Phe Val Met Val Val Met Leu Ala Ser Tyr Phe Leu 
            100                 105                 110         


Ile Ser Met Phe Gly Gly Val Met Val Phe Val Phe Gly Ile Thr Phe 
        115                 120                 125             


Pro Leu Leu Leu Met Phe Ile His Ala Ser Leu Arg Leu Arg Asn Leu 
    130                 135                 140                 


Lys Asn Lys Leu Glu Asn Lys Met Glu Gly Ile Gly Leu Lys Arg Thr 
145                 150                 155                 160 


Pro Met Gly Ile Val Leu Asp Ala Leu Glu Gln Gln Glu Glu Gly Ile 
                165                 170                 175     


Asn Arg Leu Thr Asp Tyr Ile Ser Lys Val Lys Glu 
            180                 185             


<210>  3484
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  3484

Met Ala Glu Thr Glu Ala Leu Ser Lys Leu Arg Glu Asp Phe Arg Met 
1               5                   10                  15      


Gln Asn Lys Ser Val Phe Ile Leu Gly Ala Ser Gly Glu Thr Gly Arg 
            20                  25                  30          


Val Leu Leu Lys Glu Ile Leu Glu Gln Gly Leu Phe Ser Lys Val Thr 
        35                  40                  45              


Leu Ile Gly Arg Arg Lys Leu Thr Phe Asp Glu Glu Ala Tyr Lys Asn 
    50                  55                  60                  


Val Asn Gln Glu Val Val Asp Phe Glu Lys Leu Asp Asp Tyr Ala Ser 
65                  70                  75                  80  


Ala Phe Gln Gly His Asp Val Gly Phe Cys Cys Leu Gly Thr Thr Arg 
                85                  90                  95      


Gly Lys Ala Gly Ala Glu Gly Phe Val Arg Val Asp Arg Asp Tyr Val 
            100                 105                 110         


Leu Lys Ser Ala Glu Leu Ala Lys Ala Gly Gly Cys Lys His Phe Asn 
        115                 120                 125             


Leu Leu Ser Ser Lys Gly Ala Asp Lys Ser Ser Asn Phe Leu Tyr Leu 
    130                 135                 140                 


Gln Val Lys Gly Glu Val Glu Ala Lys Val Glu Glu Leu Lys Phe Asp 
145                 150                 155                 160 


Arg Tyr Ser Val Phe Arg Pro Gly Val Leu Leu Cys Asp Arg Gln Glu 
                165                 170                 175     


Ser Arg Pro Gly Glu Trp Leu Val Arg Lys Phe Phe Gly Ser Leu Pro 
            180                 185                 190         


Asp Ser Trp Ala Ser Gly His Ser Val Pro Val Val Thr Val Val Arg 
        195                 200                 205             


Ala Met Leu Asn Asn Val Val Arg Pro Arg Asp Lys Gln Met Glu Leu 
    210                 215                 220                 


Leu Glu Asn Lys Ala Ile His Asp Leu Gly Lys Ala His Gly Ser Leu 
225                 230                 235                 240 


Lys Pro 
        


<210>  3485
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  3485

Met Asp Leu Trp Pro Gly Ala Trp Met Leu Leu Leu Leu Leu Phe Leu 
1               5                   10                  15      


Leu Leu Leu Phe Leu Leu Pro Thr Leu Trp Phe Cys Ser Pro Ser Ala 
            20                  25                  30          


Lys Tyr Phe Phe Lys Met Ala Phe Tyr Asn Gly Trp Ile Leu Phe Leu 
        35                  40                  45              


Ala Val Leu Ala Ile Pro Val Cys Ala Val Arg Gly Arg Asn Val Glu 
    50                  55                  60                  


Asn Met Lys Ile Leu Arg Leu Met Leu Leu His Ile Lys Tyr Leu Tyr 
65                  70                  75                  80  


Gly Ile Arg Val Glu Val Arg Gly Ala His His Phe Pro Pro Ser Gln 
                85                  90                  95      


Pro Tyr Val Val Val Ser Asn His Gln Ser Ser Leu Asp Leu Leu Gly 
            100                 105                 110         


Met Met Glu Val Leu Pro Gly Arg Cys Val Pro Ile Ala Lys Arg Glu 
        115                 120                 125             


Leu Leu Trp Ala Gly Ser Ala Gly Leu Ala Cys Trp Leu Ala Gly Val 
    130                 135                 140                 


Ile Phe Ile Asp Arg Lys Arg Thr Gly Asp Ala Ile Ser Val Met Ser 
145                 150                 155                 160 


Glu Val Ala Gln Thr Leu Leu Thr Gln Asp Val Arg Val Trp Val Phe 
                165                 170                 175     


Pro Glu Gly Thr Arg Asn His Asn Gly Ser Met Leu Pro Phe Lys Arg 
            180                 185                 190         


Gly Ala Phe His Leu Ala Val Gln Ala Gln Val Pro Ile Val Pro Ile 
        195                 200                 205             


Val Met Ser Ser Tyr Gln Asp Phe Tyr Cys Lys Lys Glu Arg Arg Phe 
    210                 215                 220                 


Thr Ser Gly Gln Cys Gln Val Arg Val Leu Pro Pro Val Pro Thr Glu 
225                 230                 235                 240 


Gly Leu Thr Pro Asp Asp Val Pro Ala Leu Ala Asp Arg Val Arg His 
                245                 250                 255     


Ser Met Leu Thr Val Phe Arg Glu Ile Ser Thr Asp Gly Arg Gly Gly 
            260                 265                 270         


Gly Asp Tyr Leu Lys Lys Pro Gly Gly Gly Gly 
        275                 280             


<210>  3486
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  3486

Met Glu Leu Trp Pro Cys Leu Ala Ala Ala Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Gln Leu Ser Arg Ala Ala Glu Phe Tyr Ala Lys Val Ala Leu 
            20                  25                  30          


Tyr Cys Ala Leu Cys Phe Thr Val Ser Ala Val Ala Ser Leu Val Cys 
        35                  40                  45              


Leu Leu Arg His Gly Gly Arg Thr Val Glu Asn Met Ser Ile Ile Gly 
    50                  55                  60                  


Trp Phe Val Arg Ser Phe Lys Tyr Phe Tyr Gly Leu Arg Phe Glu Val 
65                  70                  75                  80  


Arg Asp Pro Arg Arg Leu Gln Glu Ala Arg Pro Cys Val Ile Val Ser 
                85                  90                  95      


Asn His Gln Ser Ile Leu Asp Met Met Gly Leu Met Glu Val Leu Pro 
            100                 105                 110         


Glu Arg Cys Val Gln Ile Ala Lys Arg Glu Leu Leu Phe Leu Gly Pro 
        115                 120                 125             


Val Gly Leu Ile Met Tyr Leu Gly Gly Val Phe Phe Ile Asn Arg Gln 
    130                 135                 140                 


Arg Ser Ser Thr Ala Met Thr Val Met Ala Asp Leu Gly Glu Arg Met 
145                 150                 155                 160 


Val Arg Glu Asn Leu Lys Val Trp Ile Tyr Pro Glu Gly Thr Arg Asn 
                165                 170                 175     


Asp Asn Gly Asp Leu Leu Pro Phe Lys Lys Gly Ala Phe Tyr Leu Ala 
            180                 185                 190         


Val Gln Ala Gln Val Pro Ile Val Pro Val Val Tyr Ser Ser Phe Ser 
        195                 200                 205             


Ser Phe Tyr Asn Thr Lys Lys Lys Phe Phe Thr Ser Gly Thr Val Thr 
    210                 215                 220                 


Val Gln Val Leu Glu Ala Ile Pro Thr Ser Gly Leu Thr Ala Ala Asp 
225                 230                 235                 240 


Val Pro Ala Leu Val Asp Thr Cys His Arg Ala Met Arg Thr Thr Phe 
                245                 250                 255     


Leu His Ile Ser Lys Thr Pro Gln Glu Asn Gly Ala Thr Ala Gly Ser 
            260                 265                 270         


Gly Val Gln Pro Ala Gln 
        275             


<210>  3487
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  3487

Met Ala Thr Ala Thr Glu Gln Trp Val Leu Val Glu Met Val Gln Ala 
1               5                   10                  15      


Leu Tyr Glu Ala Pro Ala Tyr His Leu Ile Leu Glu Gly Ile Leu Ile 
            20                  25                  30          


Leu Trp Ile Ile Arg Leu Leu Phe Ser Lys Thr Tyr Lys Leu Gln Glu 
        35                  40                  45              


Arg Ser Asp Leu Thr Val Lys Glu Lys Glu Glu Leu Ile Glu Glu Trp 
    50                  55                  60                  


Gln Pro Glu Pro Leu Val Pro Pro Val Pro Lys Asp His Pro Ala Leu 
65                  70                  75                  80  


Asn Tyr Asn Ile Val Ser Gly Pro Pro Ser His Lys Thr Val Val Asn 
                85                  90                  95      


Gly Lys Glu Cys Ile Asn Phe Ala Ser Phe Asn Phe Leu Gly Leu Leu 
            100                 105                 110         


Asp Asn Pro Arg Val Lys Ala Ala Ala Leu Ala Ser Leu Lys Lys Tyr 
        115                 120                 125             


Gly Val Gly Thr Cys Gly Pro Arg Gly Phe Tyr Gly Thr Phe Asp Val 
    130                 135                 140                 


His Leu Asp Leu Glu Asp Arg Leu Ala Lys Phe Met Lys Thr Glu Glu 
145                 150                 155                 160 


Ala Ile Ile Tyr Ser Tyr Gly Phe Ala Thr Ile Ala Ser Ala Ile Pro 
                165                 170                 175     


Ala Tyr Ser Lys Arg Gly Asp Ile Val Phe Val Asp Arg Ala Ala Cys 
            180                 185                 190         


Phe Ala Ile Gln Lys Gly Leu Gln Ala Ser Arg Ser Asp Ile Lys Leu 
        195                 200                 205             


Phe Lys His Asn Asp Met Ala Asp Leu Glu Arg Leu Leu Lys Glu Gln 
    210                 215                 220                 


Glu Ile Glu Asp Gln Lys Asn Pro Arg Lys Ala Arg Val Thr Arg Arg 
225                 230                 235                 240 


Phe Ile Val Val Glu Gly Leu Tyr Met Asn Thr Gly Thr Ile Cys Pro 
                245                 250                 255     


Leu Pro Glu Leu Val Lys Leu Lys Tyr Lys Tyr Lys Ala Arg Ile Phe 
            260                 265                 270         


Leu Glu Glu Ser Leu Ser Phe Gly Val Leu Gly Glu His Gly Arg Gly 
        275                 280                 285             


Val Thr Glu His Tyr Gly Ile Asn Ile Asp Asp Ile Asp Leu Ile Ser 
    290                 295                 300                 


Ala Asn Met Glu Asn Ala Leu Ala Ser Ile Gly Gly Phe Cys Cys Gly 
305                 310                 315                 320 


Arg Ser Phe Val Ile Asp His Gln Arg Leu Ser Gly Gln Gly Tyr Cys 
                325                 330                 335     


Phe Ser Ala Ser Leu Pro Pro Leu Leu Ala Ala Ala Ala Ile Glu Ala 
            340                 345                 350         


Leu Asn Ile Met Glu Glu Asn Pro Gly Ile Phe Ala Val Leu Lys Glu 
        355                 360                 365             


Lys Cys Gly Gln Ile His Lys Ala Leu Gln Gly Ile Ser Gly Leu Lys 
    370                 375                 380                 


Val Val Gly Glu Ser Leu Ser Pro Ala Phe His Leu Gln Leu Glu Glu 
385                 390                 395                 400 


Ser Thr Gly Ser Arg Glu Gln Asp Val Arg Leu Leu Gln Glu Ile Val 
                405                 410                 415     


Asp Gln Cys Met Asn Arg Ser Ile Ala Leu Thr Gln Ala Arg Tyr Leu 
            420                 425                 430         


Glu Lys Glu Glu Lys Cys Leu Pro Pro Pro Ser Ile Arg Val Val Val 
        435                 440                 445             


Thr Val Glu Gln Thr Glu Glu Glu Leu Glu Arg Ala Ala Ser Thr Ile 
    450                 455                 460                 


Lys Glu Val Ala Gln Ala Val Leu Leu 
465                 470             


<210>  3488
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  3488

Met Ala Ala Pro Arg Asp Asn Val Thr Leu Leu Phe Lys Leu Tyr Cys 
1               5                   10                  15      


Leu Ala Val Met Thr Leu Met Ala Ala Val Tyr Thr Ile Ala Leu Arg 
            20                  25                  30          


Tyr Thr Arg Thr Ser Asp Lys Glu Leu Tyr Phe Ser Thr Thr Ala Val 
        35                  40                  45              


Cys Ile Thr Glu Val Ile Lys Leu Leu Leu Ser Val Gly Ile Leu Ala 
    50                  55                  60                  


Lys Glu Thr Gly Ser Leu Gly Arg Phe Lys Ala Ser Leu Arg Glu Asn 
65                  70                  75                  80  


Val Leu Gly Ser Pro Lys Glu Leu Leu Lys Leu Ser Val Pro Ser Leu 
                85                  90                  95      


Val Tyr Ala Val Gln Asn Asn Met Ala Phe Leu Ala Leu Ser Asn Leu 
            100                 105                 110         


Asp Ala Ala Val Tyr Gln Val Thr Tyr Gln Leu Lys Ile Pro Cys Thr 
        115                 120                 125             


Ala Leu Cys Thr Val Leu Met Leu Asn Arg Thr Leu Ser Lys Leu Gln 
    130                 135                 140                 


Trp Val Ser Val Phe Met Leu Cys Ala Gly Val Thr Leu Val Gln Trp 
145                 150                 155                 160 


Lys Pro Ala Gln Ala Thr Lys Val Val Val Glu Gln Asn Pro Leu Leu 
                165                 170                 175     


Gly Phe Gly Ala Ile Ala Ile Ala Val Leu Cys Ser Gly Phe Ala Gly 
            180                 185                 190         


Val Tyr Phe Glu Lys Val Leu Lys Ser Ser Asp Thr Ser Leu Trp Val 
        195                 200                 205             


Arg Asn Ile Gln Met Tyr Leu Ser Gly Ile Ile Val Thr Leu Ala Gly 
    210                 215                 220                 


Val Tyr Leu Ser Asp Gly Ala Glu Ile Lys Glu Lys Gly Phe Phe Tyr 
225                 230                 235                 240 


Gly Tyr Thr Tyr Tyr Val Trp Phe Val Ile Phe Leu Ala Ser Val Gly 
                245                 250                 255     


Gly Leu Tyr Thr Ser Val Val Val Lys Tyr Thr Asp Asn Ile Met Lys 
            260                 265                 270         


Gly Phe Ser Ala Ala Ala Ala Ile Val Leu Ser Thr Ile Ala Ser Val 
        275                 280                 285             


Met Leu Phe Gly Leu Gln Ile Thr Leu Thr Phe Ala Leu Gly Thr Leu 
    290                 295                 300                 


Leu Val Cys Val Ser Ile Tyr Leu Tyr Gly Leu Pro Arg Gln Asp Thr 
305                 310                 315                 320 


Thr Ser Ile Gln Gln Gly Glu Thr Ala Ser Lys Glu Arg Val Ile Gly 
                325                 330                 335     


Val 
    


<210>  3489
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  3489

Met Ala Ala Gln Lys Asp Gln Gln Lys Asp Ala Glu Ala Glu Gly Leu 
1               5                   10                  15      


Ser Gly Thr Thr Leu Leu Pro Lys Leu Ile Pro Ser Gly Ala Gly Arg 
            20                  25                  30          


Glu Trp Leu Glu Arg Arg Arg Ala Thr Ile Arg Pro Trp Ser Thr Phe 
        35                  40                  45              


Val Asp Gln Gln Arg Phe Ser Arg Pro Arg Asn Leu Gly Glu Leu Cys 
    50                  55                  60                  


Gln Arg Leu Val Arg Asn Val Glu Tyr Tyr Gln Ser Asn Tyr Val Phe 
65                  70                  75                  80  


Val Phe Leu Gly Leu Ile Leu Tyr Cys Val Val Thr Ser Pro Met Leu 
                85                  90                  95      


Leu Val Ala Leu Ala Val Phe Phe Gly Ala Cys Tyr Ile Leu Tyr Leu 
            100                 105                 110         


Arg Thr Leu Glu Ser Lys Leu Val Leu Phe Gly Arg Glu Val Ser Pro 
        115                 120                 125             


Ala His Gln Tyr Ala Leu Ala Gly Gly Ile Ser Phe Pro Phe Phe Trp 
    130                 135                 140                 


Leu Ala Gly Ala Gly Ser Ala Val Phe Trp Val Leu Gly Ala Thr Leu 
145                 150                 155                 160 


Val Val Ile Gly Ser His Ala Ala Phe His Gln Ile Glu Ala Val Asp 
                165                 170                 175     


Gly Glu Glu Leu Gln Met Glu Pro Val 
            180                 185 


<210>  3490
<211>  690
<212>  PRT
<213>  Homo sapiens

<400>  3490

Met Ala Pro Trp Pro Glu Leu Gly Asp Ala Gln Pro Asn Pro Asp Lys 
1               5                   10                  15      


Tyr Leu Glu Gly Ala Ala Gly Gln Gln Pro Thr Ala Pro Asp Lys Ser 
            20                  25                  30          


Lys Glu Thr Asn Lys Thr Asp Asn Thr Glu Ala Pro Val Thr Lys Ile 
        35                  40                  45              


Glu Leu Leu Pro Ser Tyr Ser Thr Ala Thr Leu Ile Asp Glu Pro Thr 
    50                  55                  60                  


Glu Val Asp Asp Pro Trp Asn Leu Pro Thr Leu Gln Asp Ser Gly Ile 
65                  70                  75                  80  


Lys Trp Ser Glu Arg Asp Thr Lys Gly Lys Ile Leu Cys Phe Phe Gln 
                85                  90                  95      


Gly Ile Gly Arg Leu Ile Leu Leu Leu Gly Phe Leu Tyr Phe Phe Val 
            100                 105                 110         


Cys Ser Leu Asp Ile Leu Ser Ser Ala Phe Gln Leu Val Gly Gly Lys 
        115                 120                 125             


Met Ala Gly Gln Phe Phe Ser Asn Ser Ser Ile Met Ser Asn Pro Leu 
    130                 135                 140                 


Leu Gly Leu Val Ile Gly Val Leu Val Thr Val Leu Val Gln Ser Ser 
145                 150                 155                 160 


Ser Thr Ser Thr Ser Ile Val Val Ser Met Val Ser Ser Ser Leu Leu 
                165                 170                 175     


Thr Val Arg Ala Ala Ile Pro Ile Ile Met Gly Ala Asn Ile Gly Thr 
            180                 185                 190         


Ser Ile Thr Asn Thr Ile Val Ala Leu Met Gln Val Gly Asp Arg Ser 
        195                 200                 205             


Glu Phe Arg Arg Ala Phe Ala Gly Ala Thr Val His Asp Phe Phe Asn 
    210                 215                 220                 


Trp Leu Ser Val Leu Val Leu Leu Pro Val Glu Val Ala Thr His Tyr 
225                 230                 235                 240 


Leu Glu Ile Ile Thr Gln Leu Ile Val Glu Ser Phe His Phe Lys Asn 
                245                 250                 255     


Gly Glu Asp Ala Pro Asp Leu Leu Lys Val Ile Thr Lys Pro Phe Thr 
            260                 265                 270         


Lys Leu Ile Val Gln Leu Asp Lys Lys Val Ile Ser Gln Ile Ala Met 
        275                 280                 285             


Asn Asp Glu Lys Ala Lys Asn Lys Ser Leu Val Lys Ile Trp Cys Lys 
    290                 295                 300                 


Thr Phe Thr Asn Lys Thr Gln Ile Asn Val Thr Val Pro Ser Thr Ala 
305                 310                 315                 320 


Asn Cys Thr Ser Pro Ser Leu Cys Trp Thr Asp Gly Ile Gln Asn Trp 
                325                 330                 335     


Thr Met Lys Asn Val Thr Tyr Lys Glu Asn Ile Ala Lys Cys Gln His 
            340                 345                 350         


Ile Phe Val Asn Phe His Leu Pro Asp Leu Ala Val Gly Thr Ile Leu 
        355                 360                 365             


Leu Ile Leu Ser Leu Leu Val Leu Cys Gly Cys Leu Ile Met Ile Val 
    370                 375                 380                 


Lys Ile Leu Gly Ser Val Leu Lys Gly Gln Val Ala Thr Val Ile Lys 
385                 390                 395                 400 


Lys Thr Ile Asn Thr Asp Phe Pro Phe Pro Phe Ala Trp Leu Thr Gly 
                405                 410                 415     


Tyr Leu Ala Ile Leu Val Gly Ala Gly Met Thr Phe Ile Val Gln Ser 
            420                 425                 430         


Ser Ser Val Phe Thr Ser Ala Leu Thr Pro Leu Ile Gly Ile Gly Val 
        435                 440                 445             


Ile Thr Ile Glu Arg Ala Tyr Pro Leu Thr Leu Gly Ser Asn Ile Gly 
    450                 455                 460                 


Thr Thr Thr Thr Ala Ile Leu Ala Ala Leu Ala Ser Pro Gly Asn Ala 
465                 470                 475                 480 


Leu Arg Ser Ser Leu Gln Ile Ala Leu Cys His Phe Phe Phe Asn Ile 
                485                 490                 495     


Ser Gly Ile Leu Leu Trp Tyr Pro Ile Pro Phe Thr Arg Leu Pro Ile 
            500                 505                 510         


Arg Met Ala Lys Gly Leu Gly Asn Ile Ser Ala Lys Tyr Arg Trp Phe 
        515                 520                 525             


Ala Val Phe Tyr Leu Ile Ile Phe Phe Phe Leu Ile Pro Leu Thr Val 
    530                 535                 540                 


Phe Gly Leu Ser Leu Ala Gly Trp Arg Val Leu Val Gly Val Gly Val 
545                 550                 555                 560 


Pro Val Val Phe Ile Ile Ile Leu Val Leu Cys Leu Arg Leu Leu Gln 
                565                 570                 575     


Ser Arg Cys Pro Arg Val Leu Pro Lys Lys Leu Gln Asn Trp Asn Phe 
            580                 585                 590         


Leu Pro Leu Trp Met Arg Ser Leu Lys Pro Trp Asp Ala Val Val Ser 
        595                 600                 605             


Lys Phe Thr Gly Cys Phe Gln Met Arg Cys Cys Cys Cys Cys Arg Val 
    610                 615                 620                 


Cys Cys Arg Ala Cys Cys Leu Leu Cys Gly Cys Pro Lys Cys Cys Arg 
625                 630                 635                 640 


Cys Ser Lys Cys Cys Glu Asp Leu Glu Glu Ala Gln Glu Gly Gln Asp 
                645                 650                 655     


Val Pro Val Lys Ala Pro Glu Thr Phe Asp Asn Ile Thr Ile Ser Arg 
            660                 665                 670         


Glu Ala Gln Gly Glu Val Pro Ala Ser Asp Ser Lys Thr Glu Cys Thr 
        675                 680                 685             


Ala Leu 
    690 


<210>  3491
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  3491

Met Asn His Ile Val Gln Thr Phe Ser Pro Val Asn Ser Gly Gln Pro 
1               5                   10                  15      


Pro Asn Tyr Glu Met Leu Lys Glu Glu Gln Glu Val Ala Met Leu Gly 
            20                  25                  30          


Val Pro His Asn Pro Ala Pro Pro Met Ser Thr Val Ile His Ile Arg 
        35                  40                  45              


Ser Glu Thr Ser Val Pro Asp His Val Val Trp Ser Leu Phe Asn Thr 
    50                  55                  60                  


Leu Phe Met Asn Thr Cys Cys Leu Gly Phe Ile Ala Phe Ala Tyr Ser 
65                  70                  75                  80  


Val Lys Ser Arg Asp Arg Lys Met Val Gly Asp Val Thr Gly Ala Gln 
                85                  90                  95      


Ala Tyr Ala Ser Thr Ala Lys Cys Leu Asn Ile Trp Ala Leu Ile Leu 
            100                 105                 110         


Gly Ile Phe Met Thr Ile Leu Leu Ile Ile Ile Pro Val Leu Val Val 
        115                 120                 125             


Gln Ala Gln Arg 
    130         


<210>  3492
<211>  691
<212>  PRT
<213>  Homo sapiens

<400>  3492

Met Asp Gln Asn Gln His Leu Asn Lys Thr Ala Glu Ala Gln Pro Ser 
1               5                   10                  15      


Glu Asn Lys Lys Thr Arg Tyr Cys Asn Gly Leu Lys Met Phe Leu Ala 
            20                  25                  30          


Ala Leu Ser Leu Ser Phe Ile Ala Lys Thr Leu Gly Ala Ile Ile Met 
        35                  40                  45              


Lys Ser Ser Ile Ile His Ile Glu Arg Arg Phe Glu Ile Ser Ser Ser 
    50                  55                  60                  


Leu Val Gly Phe Ile Asp Gly Ser Phe Glu Ile Gly Asn Leu Leu Val 
65                  70                  75                  80  


Ile Val Phe Val Ser Tyr Phe Gly Ser Lys Leu His Arg Pro Lys Leu 
                85                  90                  95      


Ile Gly Ile Gly Cys Phe Ile Met Gly Ile Gly Gly Val Leu Thr Ala 
            100                 105                 110         


Leu Pro His Phe Phe Met Gly Tyr Tyr Arg Tyr Ser Lys Glu Thr Asn 
        115                 120                 125             


Ile Asn Ser Ser Glu Asn Ser Thr Ser Thr Leu Ser Thr Cys Leu Ile 
    130                 135                 140                 


Asn Gln Ile Leu Ser Leu Asn Arg Ala Ser Pro Glu Ile Val Gly Lys 
145                 150                 155                 160 


Gly Cys Leu Lys Glu Ser Gly Ser Tyr Met Trp Ile Tyr Val Phe Met 
                165                 170                 175     


Gly Asn Met Leu Arg Gly Ile Gly Glu Thr Pro Ile Val Pro Leu Gly 
            180                 185                 190         


Leu Ser Tyr Ile Asp Asp Phe Ala Lys Glu Gly His Ser Ser Leu Tyr 
        195                 200                 205             


Leu Gly Ile Leu Asn Ala Ile Ala Met Ile Gly Pro Ile Ile Gly Phe 
    210                 215                 220                 


Thr Leu Gly Ser Leu Phe Ser Lys Met Tyr Val Asp Ile Gly Tyr Val 
225                 230                 235                 240 


Asp Leu Ser Thr Ile Arg Ile Thr Pro Thr Asp Ser Arg Trp Val Gly 
                245                 250                 255     


Ala Trp Trp Leu Asn Phe Leu Val Ser Gly Leu Phe Ser Ile Ile Ser 
            260                 265                 270         


Ser Ile Pro Phe Phe Phe Leu Pro Gln Thr Pro Asn Lys Pro Gln Lys 
        275                 280                 285             


Glu Arg Lys Ala Ser Leu Ser Leu His Val Leu Glu Thr Asn Asp Glu 
    290                 295                 300                 


Lys Asp Gln Thr Ala Asn Leu Thr Asn Gln Gly Lys Asn Ile Thr Lys 
305                 310                 315                 320 


Asn Val Thr Gly Phe Phe Gln Ser Phe Lys Ser Ile Leu Thr Asn Pro 
                325                 330                 335     


Leu Tyr Val Met Phe Val Leu Leu Thr Leu Leu Gln Val Ser Ser Tyr 
            340                 345                 350         


Ile Gly Ala Phe Thr Tyr Val Phe Lys Tyr Val Glu Gln Gln Tyr Gly 
        355                 360                 365             


Gln Pro Ser Ser Lys Ala Asn Ile Leu Leu Gly Val Ile Thr Ile Pro 
    370                 375                 380                 


Ile Phe Ala Ser Gly Met Phe Leu Gly Gly Tyr Ile Ile Lys Lys Phe 
385                 390                 395                 400 


Lys Leu Asn Thr Val Gly Ile Ala Lys Phe Ser Cys Phe Thr Ala Val 
                405                 410                 415     


Met Ser Leu Ser Phe Tyr Leu Leu Tyr Phe Phe Ile Leu Cys Glu Asn 
            420                 425                 430         


Lys Ser Val Ala Gly Leu Thr Met Thr Tyr Asp Gly Asn Asn Pro Val 
        435                 440                 445             


Thr Ser His Arg Asp Val Pro Leu Ser Tyr Cys Asn Ser Asp Cys Asn 
    450                 455                 460                 


Cys Asp Glu Ser Gln Trp Glu Pro Val Cys Gly Asn Asn Gly Ile Thr 
465                 470                 475                 480 


Tyr Ile Ser Pro Cys Leu Ala Gly Cys Lys Ser Ser Ser Gly Asn Lys 
                485                 490                 495     


Lys Pro Ile Val Phe Tyr Asn Cys Ser Cys Leu Glu Val Thr Gly Leu 
            500                 505                 510         


Gln Asn Arg Asn Tyr Ser Ala His Leu Gly Glu Cys Pro Arg Asp Asp 
        515                 520                 525             


Ala Cys Thr Arg Lys Phe Tyr Phe Phe Val Ala Ile Gln Val Leu Asn 
    530                 535                 540                 


Leu Phe Phe Ser Ala Leu Gly Gly Thr Ser His Val Met Leu Ile Val 
545                 550                 555                 560 


Lys Ile Val Gln Pro Glu Leu Lys Ser Leu Ala Leu Gly Phe His Ser 
                565                 570                 575     


Met Val Ile Arg Ala Leu Gly Gly Ile Leu Ala Pro Ile Tyr Phe Gly 
            580                 585                 590         


Ala Leu Ile Asp Thr Thr Cys Ile Lys Trp Ser Thr Asn Asn Cys Gly 
        595                 600                 605             


Thr Arg Gly Ser Cys Arg Thr Tyr Asn Ser Thr Ser Phe Ser Arg Val 
    610                 615                 620                 


Tyr Leu Gly Leu Ser Ser Met Leu Arg Val Ser Ser Leu Val Leu Tyr 
625                 630                 635                 640 


Ile Ile Leu Ile Tyr Ala Met Lys Lys Lys Tyr Gln Glu Lys Asp Ile 
                645                 650                 655     


Asn Ala Ser Glu Asn Gly Ser Val Met Asp Glu Ala Asn Leu Glu Ser 
            660                 665                 670         


Leu Asn Lys Asn Lys His Phe Val Pro Ser Ala Gly Ala Asp Ser Glu 
        675                 680                 685             


Thr His Cys 
    690     


<210>  3493
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  3493

Met Gly Leu Pro Arg Gly Ser Phe Phe Trp Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Ala Ala Cys Ser Gly Leu Leu Phe Ala Leu Tyr Phe Ser Ala Val Gln 
            20                  25                  30          


Arg Tyr Pro Gly Pro Ala Ala Gly Ala Arg Asp Thr Thr Ser Phe Glu 
        35                  40                  45              


Ala Phe Phe Gln Ser Lys Ala Ser Asn Ser Trp Thr Gly Lys Gly Gln 
    50                  55                  60                  


Ala Cys Arg His Leu Leu His Leu Ala Ile Gln Arg His Pro His Phe 
65                  70                  75                  80  


Arg Gly Leu Phe Asn Leu Ser Ile Pro Val Leu Leu Trp Gly Asp Leu 
                85                  90                  95      


Phe Thr Pro Ala Leu Trp Asp Arg Leu Ser Gln His Lys Ala Pro Tyr 
            100                 105                 110         


Gly Trp Arg Gly Leu Ser His Gln Val Ile Ala Ser Thr Leu Ser Leu 
        115                 120                 125             


Leu Asn Gly Ser Glu Ser Ala Lys Leu Phe Ala Pro Pro Arg Asp Thr 
    130                 135                 140                 


Pro Pro Lys Cys Ile Arg Cys Ala Val Val Gly Asn Gly Gly Ile Leu 
145                 150                 155                 160 


Asn Gly Ser Arg Gln Gly Pro Asn Ile Asp Ala His Asp Tyr Val Phe 
                165                 170                 175     


Arg Leu Asn Gly Ala Val Ile Lys Gly Phe Glu Arg Asp Val Gly Thr 
            180                 185                 190         


Lys Thr Ser Phe Tyr Gly Phe Thr Val Asn Thr Met Lys Asn Ser Leu 
        195                 200                 205             


Val Ser Tyr Trp Asn Leu Gly Phe Thr Ser Val Pro Gln Gly Gln Asp 
    210                 215                 220                 


Leu Gln Tyr Ile Phe Ile Pro Ser Asp Ile Arg Asp Tyr Val Met Leu 
225                 230                 235                 240 


Arg Ser Ala Ile Leu Gly Val Pro Val Pro Glu Gly Leu Asp Lys Gly 
                245                 250                 255     


Asp Arg Pro His Ala Tyr Phe Gly Pro Glu Ala Ser Ala Ser Lys Phe 
            260                 265                 270         


Lys Leu Leu His Pro Asp Phe Ile Ser Tyr Leu Thr Glu Arg Phe Leu 
        275                 280                 285             


Lys Ser Lys Leu Ile Asn Thr His Phe Gly Asp Leu Tyr Met Pro Ser 
    290                 295                 300                 


Thr Gly Ala Leu Met Leu Leu Thr Ala Leu His Thr Cys Asp Gln Val 
305                 310                 315                 320 


Ser Ala Tyr Gly Phe Ile Thr Ser Asn Tyr Trp Lys Phe Ser Asp His 
                325                 330                 335     


Tyr Phe Glu Arg Lys Met Lys Pro Leu Ile Phe Tyr Ala Asn His Asp 
            340                 345                 350         


Leu Ser Leu Glu Ala Ala Leu Trp Arg Asp Leu His Lys Ala Gly Ile 
        355                 360                 365             


Leu Gln Leu Tyr Gln Arg 
    370                 


<210>  3494
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  3494

Met Asn Met Thr Gln Ala Arg Val Leu Val Ala Ala Val Val Gly Leu 
1               5                   10                  15      


Val Ala Val Leu Leu Tyr Ala Ser Ile His Lys Ile Glu Glu Gly His 
            20                  25                  30          


Leu Ala Val Tyr Tyr Arg Gly Gly Ala Leu Leu Thr Ser Pro Ser Gly 
        35                  40                  45              


Pro Gly Tyr His Ile Met Leu Pro Phe Ile Thr Thr Phe Arg Ser Val 
    50                  55                  60                  


Gln Thr Thr Leu Gln Thr Asp Glu Val Lys Asn Val Pro Cys Gly Thr 
65                  70                  75                  80  


Ser Gly Gly Val Met Ile Tyr Ile Asp Arg Ile Glu Val Val Asn Met 
                85                  90                  95      


Leu Ala Pro Tyr Ala Val Phe Asp Ile Val Arg Asn Tyr Thr Ala Asp 
            100                 105                 110         


Tyr Asp Lys Thr Leu Ile Phe Asn Lys Ile His His Glu Leu Asn Gln 
        115                 120                 125             


Phe Cys Ser Ala His Thr Leu Gln Glu Val Tyr Ile Glu Leu Phe Asp 
    130                 135                 140                 


Gln Ile Asp Glu Asn Leu Lys Gln Ala Leu Gln Lys Asp Leu Asn Leu 
145                 150                 155                 160 


Met Ala Pro Gly Leu Thr Ile Gln Ala Val Arg Val Thr Lys Pro Lys 
                165                 170                 175     


Ile Pro Glu Ala Ile Arg Arg Asn Phe Glu Leu Met Glu Ala Glu Lys 
            180                 185                 190         


Thr Lys Leu Leu Ile Ala Ala Gln Lys Gln Lys Val Val Glu Lys Glu 
        195                 200                 205             


Ala Glu Thr Glu Arg Lys Lys Ala Val Ile Glu Ala Glu Lys Ile Ala 
    210                 215                 220                 


Gln Val Ala Lys Ile Arg Phe Gln Gln Lys Val Met Glu Lys Glu Thr 
225                 230                 235                 240 


Glu Lys Arg Ile Ser Glu Ile Glu Asp Ala Ala Phe Leu Ala Arg Glu 
                245                 250                 255     


Lys Ala Lys Ala Asp Ala Glu Tyr Tyr Ala Ala His Lys Tyr Ala Thr 
            260                 265                 270         


Ser Asn Lys His Lys Leu Thr Pro Glu Tyr Leu Glu Leu Lys Lys Tyr 
        275                 280                 285             


Gln Ala Ile Ala Ser Asn Ser Lys Ile Tyr Phe Gly Ser Asn Ile Pro 
    290                 295                 300                 


Asn Met Phe Val Asp Ser Ser Cys Ala Leu Lys Tyr Ser Asp Ile Arg 
305                 310                 315                 320 


Thr Gly Arg Glu Ser Ser Leu Pro Ser Lys Glu Ala Leu Glu Pro Ser 
                325                 330                 335     


Gly Glu Asn Val Ile Gln Asn Lys Glu Ser Thr Gly 
            340                 345             


<210>  3495
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  3495

Met Arg Phe Val Val Ala Leu Val Leu Leu Asn Val Ala Ala Ala Gly 
1               5                   10                  15      


Ala Val Pro Leu Leu Ala Thr Glu Ser Val Lys Gln Glu Glu Ala Gly 
            20                  25                  30          


Val Arg Pro Ser Ala Gly Asn Val Ser Thr His Pro Ser Leu Ser Gln 
        35                  40                  45              


Arg Pro Gly Gly Ser Thr Lys Ser His Pro Glu Pro Gln Thr Pro Lys 
    50                  55                  60                  


Asp Ser Pro Ser Lys Ser Ser Ala Glu Ala Gln Thr Pro Glu Asp Thr 
65                  70                  75                  80  


Pro Asn Lys Ser Gly Ala Glu Ala Lys Thr Gln Lys Asp Ser Ser Asn 
                85                  90                  95      


Lys Ser Gly Ala Glu Ala Lys Thr Gln Lys Gly Ser Thr Ser Lys Ser 
            100                 105                 110         


Gly Ser Glu Ala Gln Thr Thr Lys Asp Ser Thr Ser Lys Ser His Pro 
        115                 120                 125             


Glu Leu Gln Thr Pro Lys Asp Ser Thr Gly Lys Ser Gly Ala Glu Ala 
    130                 135                 140                 


Gln Thr Pro Glu Asp Ser Pro Asn Arg Ser Gly Ala Glu Ala Lys Thr 
145                 150                 155                 160 


Gln Lys Asp Ser Pro Ser Lys Ser Gly Ser Glu Ala Gln Thr Thr Lys 
                165                 170                 175     


Asp Val Pro Asn Lys Ser Gly Ala Asp Gly Gln Thr Pro Lys Asp Gly 
            180                 185                 190         


Ser Ser Lys Ser Gly Ala Glu Asp Gln Thr Pro Lys Asp Val Pro Asn 
        195                 200                 205             


Lys Ser Gly Ala Glu Lys Gln Thr Pro Lys Asp Gly Ser Asn Lys Ser 
    210                 215                 220                 


Gly Ala Glu Glu Gln Gly Pro Ile Asp Gly Pro Ser Lys Ser Gly Ala 
225                 230                 235                 240 


Glu Glu Gln Thr Ser Lys Asp Ser Pro Asn Lys Val Val Pro Glu Gln 
                245                 250                 255     


Pro Ser Arg Lys Asp His Ser Lys Pro Ile Ser Asn Pro Ser Asp Asn 
            260                 265                 270         


Lys Glu Leu Pro Lys Ala Asp Thr Asn Gln Leu Ala Asp Lys Gly Lys 
        275                 280                 285             


Leu Ser Pro His Ala Phe Lys Thr Glu Ser Gly Glu Glu Thr Asp Leu 
    290                 295                 300                 


Ile Ser Pro Pro Gln Glu Glu Val Lys Ser Ser Glu Pro Thr Glu Asp 
305                 310                 315                 320 


Val Glu Pro Lys Glu Ala Glu Asp Asp Asp Thr Gly Pro Glu Glu Gly 
                325                 330                 335     


Ser Pro Pro Lys Glu Glu Lys Glu Lys Met Ser Gly Ser Ala Ser Ser 
            340                 345                 350         


Glu Asn Arg Glu Gly Thr Leu Ser Asp Ser Thr Gly Ser Glu Lys Asp 
        355                 360                 365             


Asp Leu Tyr Pro Asn Gly Ser Gly Asn Gly Ser Ala Glu Ser Ser His 
    370                 375                 380                 


Phe Phe Ala Tyr Leu Val Thr Ala Ala Ile Leu Val Ala Val Leu Tyr 
385                 390                 395                 400 


Ile Ala His His Asn Lys Arg Lys Ile Ile Ala Phe Val Leu Glu Gly 
                405                 410                 415     


Lys Arg Ser Lys Val Thr Arg Arg Pro Lys Ala Ser Asp Tyr Gln Arg 
            420                 425                 430         


Leu Asp Gln Lys Ser 
        435         


<210>  3496
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  3496

Met Leu Thr Pro Leu Gly Lys Phe Ser Thr Ala Lys Phe Ala Val Arg 
1               5                   10                  15      


Leu Pro Arg Val Trp Glu Ala Arg Ala Pro Ser Leu Ser Gly Ala Pro 
            20                  25                  30          


Ala Pro Thr Pro Pro Ala Pro Pro Pro Ser Arg Ser Ser Arg Leu Gly 
        35                  40                  45              


Leu Trp Pro Arg Cys Phe Leu Ile Phe Pro Gln Leu Arg Ile Leu Leu 
    50                  55                  60                  


Leu Gly Pro Gln Glu Ser Asn Asn Ser Thr Gly Thr Met Trp Lys Val 
65                  70                  75                  80  


Ser Ala Leu Leu Phe Val Leu Gly Ser Ala Ser Leu Trp Val Leu Ala 
                85                  90                  95      


Glu Gly Ala Ser Thr Gly Gln Pro Glu Asp Asp Thr Glu Thr Thr Gly 
            100                 105                 110         


Leu Glu Gly Gly Val Ala Met Pro Gly Ala Glu Asp Asp Val Val Thr 
        115                 120                 125             


Pro Gly Thr Ser Glu Asp Arg Tyr Lys Ser Gly Leu Thr Thr Leu Val 
    130                 135                 140                 


Ala Thr Ser Val Asn Ser Val Thr Gly Ile Arg Ile Glu Asp Leu Pro 
145                 150                 155                 160 


Thr Ser Glu Ser Thr Val His Ala Gln Glu Gln Ser Pro Ser Ala Thr 
                165                 170                 175     


Ala Ser Asn Val Ala Thr Ser His Ser Thr Glu Lys Val Asp Gly Asp 
            180                 185                 190         


Thr Gln Thr Thr Val Glu Lys Asp Gly Leu Ser Thr Val Thr Leu Val 
        195                 200                 205             


Gly Ile Ile Val Gly Val Leu Leu Ala Ile Gly Phe Ile Gly Ala Ile 
    210                 215                 220                 


Ile Val Val Val Met Arg Lys Met Ser Gly Arg Tyr Ser Pro 
225                 230                 235             


<210>  3497
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  3497

Met Arg Arg Asn Leu Arg Leu Gly Pro Ser Ser Gly Ala Asp Ala Gln 
1               5                   10                  15      


Gly Gln Gly Ala Pro Arg Pro Gly Leu Ala Ala Pro Arg Met Leu Leu 
            20                  25                  30          


Pro Pro Ala Ser Gln Ala Ser Arg Gly Ser Gly Ser Thr Gly Cys Ser 
        35                  40                  45              


Leu Met Ala Gln Glu Val Asp Thr Ala Gln Gly Ala Glu Met Arg Arg 
    50                  55                  60                  


Gly Ala Gly Ala Ala Arg Gly Arg Ala Ser Trp Cys Trp Ala Leu Ala 
65                  70                  75                  80  


Leu Leu Trp Leu Ala Val Val Pro Gly Trp Ser Arg Val Ser Gly Ile 
                85                  90                  95      


Pro Ser Arg Arg His Trp Pro Val Pro Tyr Lys Arg Phe Asp Phe Arg 
            100                 105                 110         


Pro Lys Pro Asp Pro Tyr Cys Gln Ala Lys Tyr Thr Phe Cys Pro Thr 
        115                 120                 125             


Gly Ser Pro Ile Pro Val Met Glu Gly Asp Asp Asp Ile Glu Val Phe 
    130                 135                 140                 


Arg Leu Gln Ala Pro Val Trp Glu Phe Lys Tyr Gly Asp Leu Leu Gly 
145                 150                 155                 160 


His Leu Lys Ile Met His Asp Ala Ile Gly Phe Arg Ser Thr Leu Thr 
                165                 170                 175     


Gly Lys Asn Tyr Thr Met Glu Trp Tyr Glu Leu Phe Gln Leu Gly Asn 
            180                 185                 190         


Cys Thr Phe Pro His Leu Arg Pro Glu Met Asp Ala Pro Phe Trp Cys 
        195                 200                 205             


Asn Gln Gly Ala Ala Cys Phe Phe Glu Gly Ile Asp Asp Val His Trp 
    210                 215                 220                 


Lys Glu Asn Gly Thr Leu Val Gln Val Ala Thr Ile Ser Gly Asn Met 
225                 230                 235                 240 


Phe Asn Gln Met Ala Lys Trp Val Lys Gln Asp Asn Glu Thr Gly Ile 
                245                 250                 255     


Tyr Tyr Glu Thr Trp Asn Val Lys Ala Ser Pro Glu Lys Gly Ala Glu 
            260                 265                 270         


Thr Trp Phe Asp Ser Tyr Asp Cys Ser Lys Phe Val Leu Arg Thr Phe 
        275                 280                 285             


Asn Lys Leu Ala Glu Phe Gly Ala Glu Phe Lys Asn Ile Glu Thr Asn 
    290                 295                 300                 


Tyr Thr Arg Ile Phe Leu Tyr Ser Gly Glu Pro Thr Tyr Leu Gly Asn 
305                 310                 315                 320 


Glu Thr Ser Val Phe Gly Pro Thr Gly Asn Lys Thr Leu Gly Leu Ala 
                325                 330                 335     


Ile Lys Arg Phe Tyr Tyr Pro Phe Lys Pro His Leu Pro Thr Lys Glu 
            340                 345                 350         


Phe Leu Leu Ser Leu Leu Gln Ile Phe Asp Ala Val Ile Val His Lys 
        355                 360                 365             


Gln Phe Tyr Leu Phe Tyr Asn Phe Glu Tyr Trp Phe Leu Pro Met Lys 
    370                 375                 380                 


Phe Pro Phe Ile Lys Ile Thr Tyr Glu Glu Ile Pro Leu Pro Ile Arg 
385                 390                 395                 400 


Asn Lys Thr Leu Ser Gly Leu 
                405         


<210>  3498
<211>  548
<212>  PRT
<213>  Homo sapiens

<400>  3498

Met Lys Thr Pro Ala Asp Thr Gly Phe Ala Phe Pro Asp Trp Ala Tyr 
1               5                   10                  15      


Lys Pro Glu Ser Ser Pro Gly Ser Arg Gln Ile Gln Leu Trp His Phe 
            20                  25                  30          


Ile Leu Glu Leu Leu Arg Lys Glu Glu Tyr Gln Gly Val Ile Ala Trp 
        35                  40                  45              


Gln Gly Asp Tyr Gly Glu Phe Val Ile Lys Asp Pro Asp Glu Val Ala 
    50                  55                  60                  


Arg Leu Trp Gly Val Arg Lys Cys Lys Pro Gln Met Asn Tyr Asp Lys 
65                  70                  75                  80  


Leu Ser Arg Ala Leu Arg Tyr Tyr Tyr Asn Lys Arg Ile Leu His Lys 
                85                  90                  95      


Thr Lys Gly Lys Arg Phe Thr Tyr Lys Phe Asn Phe Asn Lys Leu Val 
            100                 105                 110         


Leu Val Asn Tyr Pro Phe Ile Asp Val Gly Leu Ala Gly Gly Ala Val 
        115                 120                 125             


Pro Gln Ser Ala Pro Pro Val Pro Ser Gly Gly Ser His Phe Arg Phe 
    130                 135                 140                 


Pro Pro Ser Thr Pro Ser Glu Val Leu Ser Pro Thr Glu Asp Pro Arg 
145                 150                 155                 160 


Ser Pro Pro Ala Cys Ser Ser Ser Ser Ser Ser Leu Phe Ser Ala Val 
                165                 170                 175     


Val Ala Arg Arg Leu Gly Arg Gly Ser Val Ser Asp Cys Ser Asp Gly 
            180                 185                 190         


Thr Ser Glu Leu Glu Glu Pro Leu Gly Glu Asp Pro Arg Ala Arg Pro 
        195                 200                 205             


Pro Gly Pro Pro Asp Leu Gly Ala Phe Arg Gly Pro Pro Leu Ala Arg 
    210                 215                 220                 


Leu Pro His Asp Pro Gly Val Phe Arg Val Tyr Pro Arg Pro Arg Gly 
225                 230                 235                 240 


Gly Pro Glu Pro Leu Ser Pro Phe Pro Val Ser Pro Leu Ala Gly Pro 
                245                 250                 255     


Gly Ser Leu Leu Pro Pro Gln Leu Ser Pro Ala Leu Pro Met Thr Pro 
            260                 265                 270         


Thr His Leu Ala Tyr Thr Pro Ser Pro Thr Leu Ser Pro Met Tyr Pro 
        275                 280                 285             


Ser Gly Gly Gly Gly Pro Ser Gly Ser Gly Gly Gly Ser His Phe Ser 
    290                 295                 300                 


Phe Ser Pro Glu Asp Met Lys Arg Tyr Leu Gln Ala His Thr Gln Ser 
305                 310                 315                 320 


Val Tyr Asn Tyr His Leu Ser Pro Arg Ala Phe Leu His Tyr Pro Gly 
                325                 330                 335     


Leu Val Val Pro Gln Pro Gln Arg Pro Asp Lys Cys Pro Leu Pro Pro 
            340                 345                 350         


Met Ala Pro Glu Thr Pro Pro Val Pro Ser Ser Ala Ser Ser Ser Ser 
        355                 360                 365             


Ser Ser Ser Ser Ser Pro Phe Lys Phe Lys Leu Gln Pro Pro Pro Leu 
    370                 375                 380                 


Gly Arg Arg Gln Arg Ala Ala Gly Glu Lys Ala Val Ala Gly Ala Asp 
385                 390                 395                 400 


Lys Ser Gly Gly Ser Ala Gly Gly Leu Ala Glu Gly Ala Gly Ala Leu 
                405                 410                 415     


Ala Pro Pro Pro Pro Pro Pro Gln Ile Lys Val Glu Pro Ile Ser Glu 
            420                 425                 430         


Gly Glu Ser Glu Glu Val Glu Val Thr Asp Ile Ser Asp Glu Asp Glu 
        435                 440                 445             


Glu Asp Gly Glu Val Phe Lys Thr Pro Arg Ala Pro Pro Ala Pro Pro 
    450                 455                 460                 


Lys Pro Glu Pro Gly Glu Ala Pro Gly Ala Ser Gln Cys Met Pro Leu 
465                 470                 475                 480 


Lys Leu Arg Phe Lys Arg Arg Trp Ser Glu Asp Cys Arg Leu Glu Gly 
                485                 490                 495     


Gly Gly Gly Pro Ala Gly Gly Phe Glu Asp Glu Gly Glu Asp Lys Lys 
            500                 505                 510         


Val Arg Gly Glu Gly Pro Gly Glu Ala Gly Gly Pro Leu Thr Pro Arg 
        515                 520                 525             


Arg Val Ser Ser Asp Leu Gln His Ala Thr Ala Gln Leu Ser Leu Glu 
    530                 535                 540                 


His Arg Asp Ser 
545             


<210>  3499
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  3499

Met Asp Pro Lys Tyr Phe Ile Leu Ile Leu Phe Cys Gly His Leu Asn 
1               5                   10                  15      


Asn Thr Phe Phe Ser Lys Thr Glu Thr Ile Thr Thr Glu Lys Gln Ser 
            20                  25                  30          


Gln Pro Thr Leu Phe Thr Ser Ser Met Ser Gln Val Leu Ala Asn Ser 
        35                  40                  45              


Gln Asn Thr Thr Gly Asn Pro Leu Gly Gln Pro Thr Gln Phe Ser Asp 
    50                  55                  60                  


Thr Phe Ser Gly Gln Ser Ile Ser Pro Ala Lys Val Thr Ala Gly Gln 
65                  70                  75                  80  


Pro Thr Pro Ala Val Tyr Thr Ser Ser Glu Lys Pro Glu Ala His Thr 
                85                  90                  95      


Ser Ala Gly Gln Pro Leu Ala Tyr Asn Thr Lys Gln Pro Thr Pro Ile 
            100                 105                 110         


Ala Asn Thr Ser Ser Gln Gln Ala Val Phe Thr Ser Ala Arg Gln Leu 
        115                 120                 125             


Pro Ser Ala Arg Thr Ser Thr Thr Gln Pro Pro Lys Ser Phe Val Tyr 
    130                 135                 140                 


Thr Phe Thr Gln Gln Ser Ser Ser Val Gln Ile Pro Ser Arg Lys Gln 
145                 150                 155                 160 


Ile Thr Val His Asn Pro Ser Thr Gln Pro Thr Ser Thr Val Lys Asn 
                165                 170                 175     


Ser Pro Arg Ser Thr Pro Gly Phe Ile Leu Asp Thr Thr Ser Asn Lys 
            180                 185                 190         


Gln Thr Pro Gln Lys Asn Asn Tyr Asn Ser Ile Ala Ala Ile Leu Ile 
        195                 200                 205             


Gly Val Leu Leu Thr Ser Met Leu Val Ala Ile Ile Ile Ile Val Leu 
    210                 215                 220                 


Trp Lys Cys Leu Arg Lys Pro Val Leu Asn Asp Gln Asn Trp Ala Gly 
225                 230                 235                 240 


Arg Ser Pro Phe Ala Asp Gly Glu Thr Pro Asp Ile Cys Met Asp Asn 
                245                 250                 255     


Ile Arg Glu Asn Glu Ile Ser Thr Lys Arg Thr Ser Ile Ile Ser Leu 
            260                 265                 270         


Thr Pro Trp Lys Pro Ser Lys Ser Thr Leu Leu Ala Asp Asp Leu Glu 
        275                 280                 285             


Ile Lys Leu Phe Glu Ser Ser Glu Asn Ile Glu Asp Ser Asn Asn Pro 
    290                 295                 300                 


Lys Thr Glu Lys Ile Lys Asp Gln Val Asn Gly Thr Ser Glu Asp Ser 
305                 310                 315                 320 


Ala Asp Gly Ser Thr Val Gly Thr Ala Val Ser Ser Ser Asp Asp Ala 
                325                 330                 335     


Asp Leu Pro Pro Pro Pro Pro Leu Leu Asp Leu Glu Gly Gln Glu Ser 
            340                 345                 350         


Asn Gln Ser Asp Lys Pro Thr Met Thr Ile Val Ser Pro Leu Pro Asn 
        355                 360                 365             


Asp Ser Thr Ser Leu Pro Pro Ser Leu Asp Cys Leu Asn Gln Asp Cys 
    370                 375                 380                 


Gly Asp His Lys Ser Glu Ile Ile Gln Ser Phe Pro Pro Leu Asp Ser 
385                 390                 395                 400 


Leu Asn Leu Pro Leu Pro Pro Val Asp Phe Met Lys Asn Gln Glu Asp 
                405                 410                 415     


Ser Asn Leu Glu Ile Gln Cys Gln Glu Phe Ser Ile Pro Pro Asn Ser 
            420                 425                 430         


Asp Gln Asp Leu Asn Glu Ser Leu Pro Pro Pro Pro Ala Glu Leu Leu 
        435                 440                 445             


<210>  3500
<211>  646
<212>  PRT
<213>  Homo sapiens

<400>  3500

Met Gly Leu Pro Arg Leu Val Cys Ala Phe Leu Leu Ala Ala Cys Cys 
1               5                   10                  15      


Cys Cys Pro Arg Val Ala Gly Val Pro Gly Glu Ala Glu Gln Pro Ala 
            20                  25                  30          


Pro Glu Leu Val Glu Val Glu Val Gly Ser Thr Ala Leu Leu Lys Cys 
        35                  40                  45              


Gly Leu Ser Gln Ser Gln Gly Asn Leu Ser His Val Asp Trp Phe Ser 
    50                  55                  60                  


Val His Lys Glu Lys Arg Thr Leu Ile Phe Arg Val Arg Gln Gly Gln 
65                  70                  75                  80  


Gly Gln Ser Glu Pro Gly Glu Tyr Glu Gln Arg Leu Ser Leu Gln Asp 
                85                  90                  95      


Arg Gly Ala Thr Leu Ala Leu Thr Gln Val Thr Pro Gln Asp Glu Arg 
            100                 105                 110         


Ile Phe Leu Cys Gln Gly Lys Arg Pro Arg Ser Gln Glu Tyr Arg Ile 
        115                 120                 125             


Gln Leu Arg Val Tyr Lys Ala Pro Glu Glu Pro Asn Ile Gln Val Asn 
    130                 135                 140                 


Pro Leu Gly Ile Pro Val Asn Ser Lys Glu Pro Glu Glu Val Ala Thr 
145                 150                 155                 160 


Cys Val Gly Arg Asn Gly Tyr Pro Ile Pro Gln Val Ile Trp Tyr Lys 
                165                 170                 175     


Asn Gly Arg Pro Leu Lys Glu Glu Lys Asn Arg Val His Ile Gln Ser 
            180                 185                 190         


Ser Gln Thr Val Glu Ser Ser Gly Leu Tyr Thr Leu Gln Ser Ile Leu 
        195                 200                 205             


Lys Ala Gln Leu Val Lys Glu Asp Lys Asp Ala Gln Phe Tyr Cys Glu 
    210                 215                 220                 


Leu Asn Tyr Arg Leu Pro Ser Gly Asn His Met Lys Glu Ser Arg Glu 
225                 230                 235                 240 


Val Thr Val Pro Val Phe Tyr Pro Thr Glu Lys Val Trp Leu Glu Val 
                245                 250                 255     


Glu Pro Val Gly Met Leu Lys Glu Gly Asp Arg Val Glu Ile Arg Cys 
            260                 265                 270         


Leu Ala Asp Gly Asn Pro Pro Pro His Phe Ser Ile Ser Lys Gln Asn 
        275                 280                 285             


Pro Ser Thr Arg Glu Ala Glu Glu Glu Thr Thr Asn Asp Asn Gly Val 
    290                 295                 300                 


Leu Val Leu Glu Pro Ala Arg Lys Glu His Ser Gly Arg Tyr Glu Cys 
305                 310                 315                 320 


Gln Gly Leu Asp Leu Asp Thr Met Ile Ser Leu Leu Ser Glu Pro Gln 
                325                 330                 335     


Glu Leu Leu Val Asn Tyr Val Ser Asp Val Arg Val Ser Pro Ala Ala 
            340                 345                 350         


Pro Glu Arg Gln Glu Gly Ser Ser Leu Thr Leu Thr Cys Glu Ala Glu 
        355                 360                 365             


Ser Ser Gln Asp Leu Glu Phe Gln Trp Leu Arg Glu Glu Thr Gly Gln 
    370                 375                 380                 


Val Leu Glu Arg Gly Pro Val Leu Gln Leu His Asp Leu Lys Arg Glu 
385                 390                 395                 400 


Ala Gly Gly Gly Tyr Arg Cys Val Ala Ser Val Pro Ser Ile Pro Gly 
                405                 410                 415     


Leu Asn Arg Thr Gln Leu Val Asn Val Ala Ile Phe Gly Pro Pro Trp 
            420                 425                 430         


Met Ala Phe Lys Glu Arg Lys Val Trp Val Lys Glu Asn Met Val Leu 
        435                 440                 445             


Asn Leu Ser Cys Glu Ala Ser Gly His Pro Arg Pro Thr Ile Ser Trp 
    450                 455                 460                 


Asn Val Asn Gly Thr Ala Ser Glu Gln Asp Gln Asp Pro Gln Arg Val 
465                 470                 475                 480 


Leu Ser Thr Leu Asn Val Leu Val Thr Pro Glu Leu Leu Glu Thr Gly 
                485                 490                 495     


Val Glu Cys Thr Ala Ser Asn Asp Leu Gly Lys Asn Thr Ser Ile Leu 
            500                 505                 510         


Phe Leu Glu Leu Val Asn Leu Thr Thr Leu Thr Pro Asp Ser Asn Thr 
        515                 520                 525             


Thr Thr Gly Leu Ser Thr Ser Thr Ala Ser Pro His Thr Arg Ala Asn 
    530                 535                 540                 


Ser Thr Ser Thr Glu Arg Lys Leu Pro Glu Pro Glu Ser Arg Gly Val 
545                 550                 555                 560 


Val Ile Val Ala Val Ile Val Cys Ile Leu Val Leu Ala Val Leu Gly 
                565                 570                 575     


Ala Val Leu Tyr Phe Leu Tyr Lys Lys Gly Lys Leu Pro Cys Arg Arg 
            580                 585                 590         


Ser Gly Lys Gln Glu Ile Thr Leu Pro Pro Ser Arg Lys Ser Glu Leu 
        595                 600                 605             


Val Val Glu Val Lys Ser Asp Lys Leu Pro Glu Glu Met Gly Leu Leu 
    610                 615                 620                 


Gln Gly Ser Ser Gly Asp Lys Arg Ala Pro Gly Asp Gln Gly Glu Lys 
625                 630                 635                 640 


Tyr Ile Asp Leu Arg His 
                645     


<210>  3501
<211>  700
<212>  PRT
<213>  Homo sapiens

<400>  3501

Met Glu Pro Leu Cys Pro Leu Leu Leu Val Gly Phe Ser Leu Pro Leu 
1               5                   10                  15      


Ala Arg Ala Leu Arg Gly Asn Glu Thr Thr Ala Asp Ser Asn Glu Thr 
            20                  25                  30          


Thr Thr Thr Ser Gly Pro Pro Asp Pro Gly Ala Ser Gln Pro Leu Leu 
        35                  40                  45              


Ala Trp Leu Leu Leu Pro Leu Leu Leu Leu Leu Leu Val Leu Leu Leu 
    50                  55                  60                  


Ala Ala Tyr Phe Phe Arg Phe Arg Lys Gln Arg Lys Ala Val Val Ser 
65                  70                  75                  80  


Thr Ser Asp Lys Lys Met Pro Asn Gly Ile Leu Glu Glu Gln Glu Gln 
                85                  90                  95      


Gln Arg Val Met Leu Leu Ser Arg Ser Pro Ser Gly Pro Lys Lys Tyr 
            100                 105                 110         


Phe Pro Ile Pro Val Glu His Leu Glu Glu Glu Ile Arg Ile Arg Ser 
        115                 120                 125             


Ala Asp Asp Cys Lys Gln Phe Arg Glu Glu Phe Asn Ser Leu Pro Ser 
    130                 135                 140                 


Gly His Ile Gln Gly Thr Phe Glu Leu Ala Asn Lys Glu Glu Asn Arg 
145                 150                 155                 160 


Glu Lys Asn Arg Tyr Pro Asn Ile Leu Pro Asn Asp His Ser Arg Val 
                165                 170                 175     


Ile Leu Ser Gln Leu Asp Gly Ile Pro Cys Ser Asp Tyr Ile Asn Ala 
            180                 185                 190         


Ser Tyr Ile Asp Gly Tyr Lys Glu Lys Asn Lys Phe Ile Ala Ala Gln 
        195                 200                 205             


Gly Pro Lys Gln Glu Thr Val Asn Asp Phe Trp Arg Met Val Trp Glu 
    210                 215                 220                 


Gln Lys Ser Ala Thr Ile Val Met Leu Thr Asn Leu Lys Glu Arg Lys 
225                 230                 235                 240 


Glu Glu Lys Cys His Gln Tyr Trp Pro Asp Gln Gly Cys Trp Thr Tyr 
                245                 250                 255     


Gly Asn Ile Arg Val Cys Val Glu Asp Cys Val Val Leu Val Asp Tyr 
            260                 265                 270         


Thr Ile Arg Lys Phe Cys Ile Gln Pro Gln Leu Pro Asp Gly Cys Lys 
        275                 280                 285             


Ala Pro Arg Leu Val Ser Gln Leu His Phe Thr Ser Trp Pro Asp Phe 
    290                 295                 300                 


Gly Val Pro Phe Thr Pro Ile Gly Met Leu Lys Phe Leu Lys Lys Val 
305                 310                 315                 320 


Lys Thr Leu Asn Pro Val His Ala Gly Pro Ile Val Val His Cys Ser 
                325                 330                 335     


Ala Gly Val Gly Arg Thr Gly Thr Phe Ile Val Ile Asp Ala Met Met 
            340                 345                 350         


Ala Met Met His Ala Glu Gln Lys Val Asp Val Phe Glu Phe Val Ser 
        355                 360                 365             


Arg Ile Arg Asn Gln Arg Pro Gln Met Val Gln Thr Asp Met Gln Tyr 
    370                 375                 380                 


Thr Phe Ile Tyr Gln Ala Leu Leu Glu Tyr Tyr Leu Tyr Gly Asp Thr 
385                 390                 395                 400 


Glu Leu Asp Val Ser Ser Leu Glu Lys His Leu Gln Thr Met His Gly 
                405                 410                 415     


Thr Thr Thr His Phe Asp Lys Ile Gly Leu Glu Glu Glu Phe Arg Lys 
            420                 425                 430         


Leu Thr Asn Val Arg Ile Met Lys Glu Asn Met Arg Thr Gly Asn Leu 
        435                 440                 445             


Pro Ala Asn Met Lys Lys Ala Arg Val Ile Gln Ile Ile Pro Tyr Asp 
    450                 455                 460                 


Phe Asn Arg Val Ile Leu Ser Met Lys Arg Gly Gln Glu Tyr Thr Asp 
465                 470                 475                 480 


Tyr Ile Asn Ala Ser Phe Ile Asp Gly Tyr Arg Gln Lys Asp Tyr Phe 
                485                 490                 495     


Ile Ala Thr Gln Gly Pro Leu Ala His Thr Val Glu Asp Phe Trp Arg 
            500                 505                 510         


Met Ile Trp Glu Trp Lys Ser His Thr Ile Val Met Leu Thr Glu Val 
        515                 520                 525             


Gln Glu Arg Glu Gln Asp Lys Cys Tyr Gln Tyr Trp Pro Thr Glu Gly 
    530                 535                 540                 


Ser Val Thr His Gly Glu Ile Thr Ile Glu Ile Lys Asn Asp Thr Leu 
545                 550                 555                 560 


Ser Glu Ala Ile Ser Ile Arg Asp Phe Leu Val Thr Leu Asn Gln Pro 
                565                 570                 575     


Gln Ala Arg Gln Glu Glu Gln Val Arg Val Val Arg Gln Phe His Phe 
            580                 585                 590         


His Gly Trp Pro Glu Ile Gly Ile Pro Ala Glu Gly Lys Gly Met Ile 
        595                 600                 605             


Asp Leu Ile Ala Ala Val Gln Lys Gln Gln Gln Gln Thr Gly Asn His 
    610                 615                 620                 


Pro Ile Thr Val His Cys Ser Ala Gly Ala Gly Arg Thr Gly Thr Phe 
625                 630                 635                 640 


Ile Ala Leu Ser Asn Ile Leu Glu Arg Val Lys Ala Glu Gly Leu Leu 
                645                 650                 655     


Asp Val Phe Gln Ala Val Lys Ser Leu Arg Leu Gln Arg Pro His Met 
            660                 665                 670         


Val Gln Thr Leu Glu Gln Tyr Glu Phe Cys Tyr Lys Val Val Gln Asp 
        675                 680                 685             


Phe Ile Asp Ile Phe Ser Asp Tyr Ala Asn Phe Lys 
    690                 695                 700 


<210>  3502
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  3502

Met Ala Arg Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu 
1               5                   10                  15      


Leu Val Leu Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln 
            20                  25                  30          


Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro 
        35                  40                  45              


Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu 
    50                  55                  60                  


Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln 
65                  70                  75                  80  


Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala 
                85                  90                  95      


Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly 
            100                 105                 110         


Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe 
        115                 120                 125             


Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys 
    130                 135                 140                 


Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro 
145                 150                 155                 160 


Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln 
                165                 170                 175     


Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val 
            180                 185                 190         


Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu 
        195                 200                 205             


Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu 
    210                 215                 220                 


His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val 
225                 230                 235                 240 


Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr 
                245                 250                 255     


Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro 
            260                 265                 270         


Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro 
        275                 280                 285             


Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys 
    290                 295                 300                 


Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala 
305                 310                 315                 320 


Arg Gln Ala Glu Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu 
                325                 330                 335     


His Ser Gly Met Ser Arg Asn Ala Ile Ile Phe Leu Val Leu Gly Ile 
            340                 345                 350         


Leu Val Phe Leu Ile Leu Leu Gly Ile Gly Ile Tyr Phe Tyr Trp Ser 
        355                 360                 365             


Lys Cys Ser Arg Glu Val Leu Trp His Cys His Leu Cys Pro Ser Ser 
    370                 375                 380                 


Thr Glu His Ala Ser Ala Ser Ala Asn Gly His Val Ser Tyr Ser Ala 
385                 390                 395                 400 


Val Ser Arg Glu Asn Ser Ser Ser Gln Asp Pro Gln Thr Glu Gly Thr 
                405                 410                 415     


Arg 
    


<210>  3503
<211>  1956
<212>  PRT
<213>  Homo sapiens

<400>  3503

Met Glu Phe Pro Ile Gly Ser Leu Glu Thr Asn Asn Phe Arg Arg Phe 
1               5                   10                  15      


Thr Pro Glu Ser Leu Val Glu Ile Glu Lys Gln Ile Ala Ala Lys Gln 
            20                  25                  30          


Gly Thr Lys Lys Ala Arg Glu Lys His Arg Glu Gln Lys Asp Gln Glu 
        35                  40                  45              


Glu Lys Pro Arg Pro Gln Leu Asp Leu Lys Ala Cys Asn Gln Leu Pro 
    50                  55                  60                  


Lys Phe Tyr Gly Glu Leu Pro Ala Glu Leu Ile Gly Glu Pro Leu Glu 
65                  70                  75                  80  


Asp Leu Asp Pro Phe Tyr Ser Thr His Arg Thr Phe Met Val Leu Asn 
                85                  90                  95      


Lys Gly Arg Thr Ile Ser Arg Phe Ser Ala Thr Arg Ala Leu Trp Leu 
            100                 105                 110         


Phe Ser Pro Phe Asn Leu Ile Arg Arg Thr Ala Ile Lys Val Ser Val 
        115                 120                 125             


His Ser Trp Phe Ser Leu Phe Ile Thr Val Thr Ile Leu Val Asn Cys 
    130                 135                 140                 


Val Cys Met Thr Arg Thr Asp Leu Pro Glu Lys Ile Glu Tyr Val Phe 
145                 150                 155                 160 


Thr Val Ile Tyr Thr Phe Glu Ala Leu Ile Lys Ile Leu Ala Arg Gly 
                165                 170                 175     


Phe Cys Leu Asn Glu Phe Thr Tyr Leu Arg Asp Pro Trp Asn Trp Leu 
            180                 185                 190         


Asp Phe Ser Val Ile Thr Leu Ala Tyr Val Gly Thr Ala Ile Asp Leu 
        195                 200                 205             


Arg Gly Ile Ser Gly Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys 
    210                 215                 220                 


Thr Val Ser Val Ile Pro Gly Leu Lys Val Ile Val Gly Ala Leu Ile 
225                 230                 235                 240 


His Ser Val Lys Lys Leu Ala Asp Val Thr Ile Leu Thr Ile Phe Cys 
                245                 250                 255     


Leu Ser Val Phe Ala Leu Val Gly Leu Gln Leu Phe Lys Gly Asn Leu 
            260                 265                 270         


Lys Asn Lys Cys Val Lys Asn Asp Met Ala Val Asn Glu Thr Thr Asn 
        275                 280                 285             


Tyr Ser Ser His Arg Lys Pro Asp Ile Tyr Ile Asn Lys Arg Gly Thr 
    290                 295                 300                 


Ser Asp Pro Leu Leu Cys Gly Asn Gly Ser Asp Ser Gly His Cys Pro 
305                 310                 315                 320 


Asp Gly Tyr Ile Cys Leu Lys Thr Ser Asp Asn Pro Asp Phe Asn Tyr 
                325                 330                 335     


Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ser Leu Phe Arg Leu 
            340                 345                 350         


Met Thr Gln Asp Ser Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Thr 
        355                 360                 365             


Ser Gly Lys Ile Tyr Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly 
    370                 375                 380                 


Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Thr Met Ala Tyr 
385                 390                 395                 400 


Glu Glu Gln Asn Gln Ala Thr Thr Asp Glu Ile Glu Ala Lys Glu Lys 
                405                 410                 415     


Lys Phe Gln Glu Ala Leu Glu Met Leu Arg Lys Glu Gln Glu Val Leu 
            420                 425                 430         


Ala Ala Leu Gly Ile Asp Thr Thr Ser Leu His Ser His Asn Gly Ser 
        435                 440                 445             


Pro Leu Thr Ser Lys Asn Ala Ser Glu Arg Arg His Arg Ile Lys Pro 
    450                 455                 460                 


Arg Val Ser Glu Gly Ser Thr Glu Asp Asn Lys Ser Pro Arg Ser Asp 
465                 470                 475                 480 


Pro Tyr Asn Gln Arg Arg Met Ser Phe Leu Gly Leu Ala Ser Gly Lys 
                485                 490                 495     


Arg Arg Ala Ser His Gly Ser Val Phe His Phe Arg Ser Pro Gly Arg 
            500                 505                 510         


Asp Ile Ser Leu Pro Glu Gly Val Thr Asp Asp Gly Val Phe Pro Gly 
        515                 520                 525             


Asp His Glu Ser His Arg Gly Ser Leu Leu Leu Gly Gly Gly Ala Gly 
    530                 535                 540                 


Gln Gln Gly Pro Leu Pro Arg Ser Pro Leu Pro Gln Pro Ser Asn Pro 
545                 550                 555                 560 


Asp Ser Arg His Gly Glu Asp Glu His Gln Pro Pro Pro Thr Ser Glu 
                565                 570                 575     


Leu Ala Pro Gly Ala Val Asp Val Ser Ala Phe Asp Ala Gly Gln Lys 
            580                 585                 590         


Lys Thr Phe Leu Ser Ala Glu Tyr Leu Asp Glu Pro Phe Arg Ala Gln 
        595                 600                 605             


Arg Ala Met Ser Val Val Ser Ile Ile Thr Ser Val Leu Glu Glu Leu 
    610                 615                 620                 


Glu Glu Ser Glu Gln Lys Cys Pro Pro Cys Leu Thr Ser Leu Ser Gln 
625                 630                 635                 640 


Lys Tyr Leu Ile Trp Asp Cys Cys Pro Met Trp Val Lys Leu Lys Thr 
                645                 650                 655     


Ile Leu Phe Gly Leu Val Thr Asp Pro Phe Ala Glu Leu Thr Ile Thr 
            660                 665                 670         


Leu Cys Ile Val Val Asn Thr Ile Phe Met Ala Met Glu His His Gly 
        675                 680                 685             


Met Ser Pro Thr Phe Glu Ala Met Leu Gln Ile Gly Asn Ile Val Phe 
    690                 695                 700                 


Thr Ile Phe Phe Thr Ala Glu Met Val Phe Lys Ile Ile Ala Phe Asp 
705                 710                 715                 720 


Pro Tyr Tyr Tyr Phe Gln Lys Lys Trp Asn Ile Phe Asp Cys Ile Ile 
                725                 730                 735     


Val Thr Val Ser Leu Leu Glu Leu Gly Val Ala Lys Lys Gly Ser Leu 
            740                 745                 750         


Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys 
        755                 760                 765             


Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile Gly Asn Ser Val 
    770                 775                 780                 


Gly Ala Leu Gly Asn Leu Thr Ile Ile Leu Ala Ile Ile Val Phe Val 
785                 790                 795                 800 


Phe Ala Leu Val Gly Lys Gln Leu Leu Gly Glu Asn Tyr Arg Asn Asn 
                805                 810                 815     


Arg Lys Asn Ile Ser Ala Pro His Glu Asp Trp Pro Arg Trp His Met 
            820                 825                 830         


His Asp Phe Phe His Ser Phe Leu Ile Val Phe Arg Ile Leu Cys Gly 
        835                 840                 845             


Glu Trp Ile Glu Asn Met Trp Ala Cys Met Glu Val Gly Gln Lys Ser 
    850                 855                 860                 


Ile Cys Leu Ile Leu Phe Leu Thr Val Met Val Leu Gly Asn Leu Val 
865                 870                 875                 880 


Val Leu Asn Leu Phe Ile Ala Leu Leu Leu Asn Ser Phe Ser Ala Asp 
                885                 890                 895     


Asn Leu Thr Ala Pro Glu Asp Asp Gly Glu Val Asn Asn Leu Gln Val 
            900                 905                 910         


Ala Leu Ala Arg Ile Gln Val Phe Gly His Arg Thr Lys Gln Ala Leu 
        915                 920                 925             


Cys Ser Phe Phe Ser Arg Ser Cys Pro Phe Pro Gln Pro Lys Ala Glu 
    930                 935                 940                 


Pro Glu Leu Val Val Lys Leu Pro Leu Ser Ser Ser Lys Ala Glu Asn 
945                 950                 955                 960 


His Ile Ala Ala Asn Thr Ala Arg Gly Ser Ser Gly Gly Leu Gln Ala 
                965                 970                 975     


Pro Arg Gly Pro Arg Asp Glu His Ser Asp Phe Ile Ala Asn Pro Thr 
            980                 985                 990         


Val Trp Val Ser Val Pro Ile Ala  Glu Gly Glu Ser Asp  Leu Asp Asp 
        995                 1000                 1005             


Leu Glu  Asp Asp Gly Gly Glu  Asp Ala Gln Ser Phe  Gln Gln Glu 
    1010                 1015                 1020             


Val Ile  Pro Lys Gly Gln Gln  Glu Gln Leu Gln Gln  Val Glu Arg 
    1025                 1030                 1035             


Cys Gly  Asp His Leu Thr Pro  Arg Ser Pro Gly Thr  Gly Thr Ser 
    1040                 1045                 1050             


Ser Glu  Asp Leu Ala Pro Ser  Leu Gly Glu Thr Trp  Lys Asp Glu 
    1055                 1060                 1065             


Ser Val  Pro Gln Val Pro Ala  Glu Gly Val Asp Asp  Thr Ser Ser 
    1070                 1075                 1080             


Ser Glu  Gly Ser Thr Val Asp  Cys Leu Asp Pro Glu  Glu Ile Leu 
    1085                 1090                 1095             


Arg Lys  Ile Pro Glu Leu Ala  Asp Asp Leu Glu Glu  Pro Asp Asp 
    1100                 1105                 1110             


Cys Phe  Thr Glu Gly Cys Ile  Arg His Cys Pro Cys  Cys Lys Leu 
    1115                 1120                 1125             


Asp Thr  Thr Lys Ser Pro Trp  Asp Val Gly Trp Gln  Val Arg Lys 
    1130                 1135                 1140             


Thr Cys  Tyr Arg Ile Val Glu  His Ser Trp Phe Glu  Ser Phe Ile 
    1145                 1150                 1155             


Ile Phe  Met Ile Leu Leu Ser  Ser Gly Ser Leu Ala  Phe Glu Asp 
    1160                 1165                 1170             


Tyr Tyr  Leu Asp Gln Lys Pro  Thr Val Lys Ala Leu  Leu Glu Tyr 
    1175                 1180                 1185             


Thr Asp  Arg Val Phe Thr Phe  Ile Phe Val Phe Glu  Met Leu Leu 
    1190                 1195                 1200             


Lys Trp  Val Ala Tyr Gly Phe  Lys Lys Tyr Phe Thr  Asn Ala Trp 
    1205                 1210                 1215             


Cys Trp  Leu Asp Phe Leu Ile  Val Asn Ile Ser Leu  Ile Ser Leu 
    1220                 1225                 1230             


Thr Ala  Lys Ile Leu Glu Tyr  Ser Glu Val Ala Pro  Ile Lys Ala 
    1235                 1240                 1245             


Leu Arg  Thr Leu Arg Ala Leu  Arg Pro Leu Arg Ala  Leu Ser Arg 
    1250                 1255                 1260             


Phe Glu  Gly Met Arg Val Val  Val Asp Ala Leu Val  Gly Ala Ile 
    1265                 1270                 1275             


Pro Ser  Ile Met Asn Val Leu  Leu Val Cys Leu Ile  Phe Trp Leu 
    1280                 1285                 1290             


Ile Phe  Ser Ile Met Gly Val  Asn Leu Phe Ala Gly  Lys Phe Trp 
    1295                 1300                 1305             


Arg Cys  Ile Asn Tyr Thr Asp  Gly Glu Phe Ser Leu  Val Pro Leu 
    1310                 1315                 1320             


Ser Ile  Val Asn Asn Lys Ser  Asp Cys Lys Ile Gln  Asn Ser Thr 
    1325                 1330                 1335             


Gly Ser  Phe Phe Trp Val Asn  Val Lys Val Asn Phe  Asp Asn Val 
    1340                 1345                 1350             


Ala Met  Gly Tyr Leu Ala Leu  Leu Gln Val Ala Thr  Phe Lys Gly 
    1355                 1360                 1365             


Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp Ser Arg  Glu Val Asn 
    1370                 1375                 1380             


Met Gln  Pro Lys Trp Glu Asp  Asn Val Tyr Met Tyr  Leu Tyr Phe 
    1385                 1390                 1395             


Val Ile  Phe Ile Ile Phe Gly  Gly Phe Phe Thr Leu  Asn Leu Phe 
    1400                 1405                 1410             


Val Gly  Val Ile Ile Asp Asn  Phe Asn Gln Gln Lys  Lys Lys Leu 
    1415                 1420                 1425             


Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu Gln Lys  Lys Tyr Tyr 
    1430                 1435                 1440             


Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys Pro Gln  Lys Pro Ile 
    1445                 1450                 1455             


Pro Arg  Pro Leu Asn Lys Phe  Gln Gly Phe Val Phe  Asp Ile Val 
    1460                 1465                 1470             


Thr Arg  Gln Ala Phe Asp Ile  Thr Ile Met Val Leu  Ile Cys Leu 
    1475                 1480                 1485             


Asn Met  Ile Thr Met Met Val  Glu Thr Asp Asp Gln  Ser Glu Glu 
    1490                 1495                 1500             


Lys Thr  Lys Ile Leu Gly Lys  Ile Asn Gln Phe Phe  Val Ala Val 
    1505                 1510                 1515             


Phe Thr  Gly Glu Cys Val Met  Lys Met Phe Ala Leu  Arg Gln Tyr 
    1520                 1525                 1530             


Tyr Phe  Thr Asn Gly Trp Asn  Val Phe Asp Phe Ile  Val Val Val 
    1535                 1540                 1545             


Leu Ser  Ile Ala Ser Leu Ile  Phe Ser Ala Ile Leu  Lys Ser Leu 
    1550                 1555                 1560             


Gln Ser  Tyr Phe Ser Pro Thr  Leu Phe Arg Val Ile  Arg Leu Ala 
    1565                 1570                 1575             


Arg Ile  Gly Arg Ile Leu Arg  Leu Ile Arg Ala Ala  Lys Gly Ile 
    1580                 1585                 1590             


Arg Thr  Leu Leu Phe Ala Leu  Met Met Ser Leu Pro  Ala Leu Phe 
    1595                 1600                 1605             


Asn Ile  Gly Leu Leu Leu Phe  Leu Val Met Phe Ile  Tyr Ser Ile 
    1610                 1615                 1620             


Phe Gly  Met Ser Ser Phe Pro  His Val Arg Trp Glu  Ala Gly Ile 
    1625                 1630                 1635             


Asp Asp  Met Phe Asn Phe Gln  Thr Phe Ala Asn Ser  Met Leu Cys 
    1640                 1645                 1650             


Leu Phe  Gln Ile Thr Thr Ser  Ala Gly Trp Asp Gly  Leu Leu Ser 
    1655                 1660                 1665             


Pro Ile  Leu Asn Thr Gly Pro  Pro Tyr Cys Asp Pro  Asn Leu Pro 
    1670                 1675                 1680             


Asn Ser  Asn Gly Thr Arg Gly  Asp Cys Gly Ser Pro  Ala Val Gly 
    1685                 1690                 1695             


Ile Ile  Phe Phe Thr Thr Tyr  Ile Ile Ile Ser Phe  Leu Ile Val 
    1700                 1705                 1710             


Val Asn  Met Tyr Ile Ala Val  Ile Leu Glu Asn Phe  Asn Val Ala 
    1715                 1720                 1725             


Thr Glu  Glu Ser Thr Glu Pro  Leu Ser Glu Asp Asp  Phe Asp Met 
    1730                 1735                 1740             


Phe Tyr  Glu Thr Trp Glu Lys  Phe Asp Pro Glu Ala  Thr Gln Phe 
    1745                 1750                 1755             


Ile Thr  Phe Ser Ala Leu Ser  Asp Phe Ala Asp Thr  Leu Ser Gly 
    1760                 1765                 1770             


Pro Leu  Arg Ile Pro Lys Pro  Asn Arg Asn Ile Leu  Ile Gln Met 
    1775                 1780                 1785             


Asp Leu  Pro Leu Val Pro Gly  Asp Lys Ile His Cys  Leu Asp Ile 
    1790                 1795                 1800             


Leu Phe  Ala Phe Thr Lys Asn  Val Leu Gly Glu Ser  Gly Glu Leu 
    1805                 1810                 1815             


Asp Ser  Leu Lys Ala Asn Met  Glu Glu Lys Phe Met  Ala Thr Asn 
    1820                 1825                 1830             


Leu Ser  Lys Ser Ser Tyr Glu  Pro Ile Ala Thr Thr  Leu Arg Trp 
    1835                 1840                 1845             


Lys Gln  Glu Asp Ile Ser Ala  Thr Val Ile Gln Lys  Ala Tyr Arg 
    1850                 1855                 1860             


Ser Tyr  Val Leu His Arg Ser  Met Ala Leu Ser Asn  Thr Pro Cys 
    1865                 1870                 1875             


Val Pro  Arg Ala Glu Glu Glu  Ala Ala Ser Leu Pro  Asp Glu Gly 
    1880                 1885                 1890             


Phe Val  Ala Phe Thr Ala Asn  Glu Asn Cys Val Leu  Pro Asp Lys 
    1895                 1900                 1905             


Ser Glu  Thr Ala Ser Ala Thr  Ser Phe Pro Pro Ser  Tyr Glu Ser 
    1910                 1915                 1920             


Val Thr  Arg Gly Leu Ser Asp  Arg Val Asn Met Arg  Thr Ser Ser 
    1925                 1930                 1935             


Ser Ile  Gln Asn Glu Asp Glu  Ala Thr Ser Met Glu  Leu Ile Ala 
    1940                 1945                 1950             


Pro Gly  Pro 
    1955     


<210>  3504
<211>  492
<212>  PRT
<213>  Homo sapiens

<400>  3504

Met Glu Pro Ser Ser Lys Lys Leu Thr Gly Arg Leu Met Leu Ala Val 
1               5                   10                  15      


Gly Gly Ala Val Leu Gly Ser Leu Gln Phe Gly Tyr Asn Thr Gly Val 
            20                  25                  30          


Ile Asn Ala Pro Gln Lys Val Ile Glu Glu Phe Tyr Asn Gln Thr Trp 
        35                  40                  45              


Val His Arg Tyr Gly Glu Ser Ile Leu Pro Thr Thr Leu Thr Thr Leu 
    50                  55                  60                  


Trp Ser Leu Ser Val Ala Ile Phe Ser Val Gly Gly Met Ile Gly Ser 
65                  70                  75                  80  


Phe Ser Val Gly Leu Phe Val Asn Arg Phe Gly Arg Arg Asn Ser Met 
                85                  90                  95      


Leu Met Met Asn Leu Leu Ala Phe Val Ser Ala Val Leu Met Gly Phe 
            100                 105                 110         


Ser Lys Leu Gly Lys Ser Phe Glu Met Leu Ile Leu Gly Arg Phe Ile 
        115                 120                 125             


Ile Gly Val Tyr Cys Gly Leu Thr Thr Gly Phe Val Pro Met Tyr Val 
    130                 135                 140                 


Gly Glu Val Ser Pro Thr Ala Leu Arg Gly Ala Leu Gly Thr Leu His 
145                 150                 155                 160 


Gln Leu Gly Ile Val Val Gly Ile Leu Ile Ala Gln Val Phe Gly Leu 
                165                 170                 175     


Asp Ser Ile Met Gly Asn Lys Asp Leu Trp Pro Leu Leu Leu Ser Ile 
            180                 185                 190         


Ile Phe Ile Pro Ala Leu Leu Gln Cys Ile Val Leu Pro Phe Cys Pro 
        195                 200                 205             


Glu Ser Pro Arg Phe Leu Leu Ile Asn Arg Asn Glu Glu Asn Arg Ala 
    210                 215                 220                 


Lys Ser Val Leu Lys Lys Leu Arg Gly Thr Ala Asp Val Thr His Asp 
225                 230                 235                 240 


Leu Gln Glu Met Lys Glu Glu Ser Arg Gln Met Met Arg Glu Lys Lys 
                245                 250                 255     


Val Thr Ile Leu Glu Leu Phe Arg Ser Pro Ala Tyr Arg Gln Pro Ile 
            260                 265                 270         


Leu Ile Ala Val Val Leu Gln Leu Ser Gln Gln Leu Ser Gly Ile Asn 
        275                 280                 285             


Ala Val Phe Tyr Tyr Ser Thr Ser Ile Phe Glu Lys Ala Gly Val Gln 
    290                 295                 300                 


Gln Pro Val Tyr Ala Thr Ile Gly Ser Gly Ile Val Asn Thr Ala Phe 
305                 310                 315                 320 


Thr Val Val Ser Leu Phe Val Val Glu Arg Ala Gly Arg Arg Thr Leu 
                325                 330                 335     


His Leu Ile Gly Leu Ala Gly Met Ala Gly Cys Ala Ile Leu Met Thr 
            340                 345                 350         


Ile Ala Leu Ala Leu Leu Glu Gln Leu Pro Trp Met Ser Tyr Leu Ser 
        355                 360                 365             


Ile Val Ala Ile Phe Gly Phe Val Ala Phe Phe Glu Val Gly Pro Gly 
    370                 375                 380                 


Pro Ile Pro Trp Phe Ile Val Ala Glu Leu Phe Ser Gln Gly Pro Arg 
385                 390                 395                 400 


Pro Ala Ala Ile Ala Val Ala Gly Phe Ser Asn Trp Thr Ser Asn Phe 
                405                 410                 415     


Ile Val Gly Met Cys Phe Gln Tyr Val Glu Gln Leu Cys Gly Pro Tyr 
            420                 425                 430         


Val Phe Ile Ile Phe Thr Val Leu Leu Val Leu Phe Phe Ile Phe Thr 
        435                 440                 445             


Tyr Phe Lys Val Pro Glu Thr Lys Gly Arg Thr Phe Asp Glu Ile Ala 
    450                 455                 460                 


Ser Gly Phe Arg Gln Gly Gly Ala Ser Gln Ser Asp Lys Thr Pro Glu 
465                 470                 475                 480 


Glu Leu Phe His Pro Leu Gly Ala Asp Ser Gln Val 
                485                 490         


<210>  3505
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  3505

Met Ala Leu Gln Ser Gln Ala Ser Glu Glu Ala Lys Gly Pro Trp Gln 
1               5                   10                  15      


Glu Ala Asp Gln Glu Gln Gln Glu Pro Val Gly Ser Pro Glu Pro Glu 
            20                  25                  30          


Ser Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Val Pro Val Pro Pro 
        35                  40                  45              


Pro Glu Pro Gln Pro Glu Pro Gln Pro Leu Pro Asp Pro Ala Pro Leu 
    50                  55                  60                  


Pro Glu Leu Glu Phe Glu Ser Glu Arg Val His Glu Pro Glu Pro Thr 
65                  70                  75                  80  


Pro Thr Val Glu Thr Arg Gly Thr Ala Arg Gly Phe Gln Pro Pro Glu 
                85                  90                  95      


Gly Gly Phe Gly Trp Val Val Val Phe Ala Ala Thr Trp Cys Asn Gly 
            100                 105                 110         


Ser Ile Phe Gly Ile His Asn Ser Val Gly Ile Leu Tyr Ser Met Leu 
        115                 120                 125             


Leu Glu Glu Glu Lys Glu Lys Asn Arg Gln Val Glu Phe Gln Ala Ala 
    130                 135                 140                 


Trp Val Gly Ala Leu Ala Met Gly Met Ile Phe Phe Cys Ser Pro Ile 
145                 150                 155                 160 


Val Ser Ile Phe Thr Asp Arg Leu Gly Cys Arg Ile Thr Ala Thr Ala 
                165                 170                 175     


Gly Ala Ala Val Ala Phe Ile Gly Leu His Thr Ser Ser Phe Thr Ser 
            180                 185                 190         


Ser Leu Ser Leu Arg Tyr Phe Thr Tyr Gly Ile Leu Phe Gly Cys Gly 
        195                 200                 205             


Cys Ser Phe Ala Phe Gln Pro Ser Leu Val Ile Leu Gly His Tyr Phe 
    210                 215                 220                 


Gln Arg Arg Leu Gly Leu Ala Asn Gly Val Val Ser Ala Gly Ser Ser 
225                 230                 235                 240 


Ile Phe Ser Met Ser Phe Pro Phe Leu Ile Arg Met Leu Gly Asp Lys 
                245                 250                 255     


Ile Lys Leu Ala Gln Thr Phe Gln Val Leu Ser Thr Phe Met Phe Val 
            260                 265                 270         


Leu Met Leu Leu Ser Leu Thr Tyr Arg Pro Leu Leu Pro Ser Ser Gln 
        275                 280                 285             


Asp Thr Pro Ser Lys Arg Gly Val Arg Thr Leu His Gln Arg Phe Leu 
    290                 295                 300                 


Ala Gln Leu Arg Lys Tyr Phe Asn Met Arg Val Phe Arg Gln Arg Thr 
305                 310                 315                 320 


Tyr Arg Ile Trp Ala Phe Gly Ile Ala Ala Ala Ala Leu Gly Tyr Phe 
                325                 330                 335     


Val Pro Tyr Val His Leu Met Lys Tyr Val Glu Glu Glu Phe Ser Glu 
            340                 345                 350         


Ile Lys Glu Thr Trp Val Leu Leu Val Cys Ile Gly Ala Thr Ser Gly 
        355                 360                 365             


Leu Gly Arg Leu Val Ser Gly His Ile Ser Asp Ser Ile Pro Gly Leu 
    370                 375                 380                 


Lys Lys Ile Tyr Leu Gln Val Leu Ser Phe Leu Leu Leu Gly Leu Met 
385                 390                 395                 400 


Ser Met Met Ile Pro Leu Cys Arg Asp Phe Gly Gly Leu Ile Val Val 
                405                 410                 415     


Cys Leu Phe Leu Gly Leu Cys Asp Gly Phe Phe Ile Thr Ile Met Ala 
            420                 425                 430         


Pro Ile Ala Phe Glu Leu Val Gly Pro Met Gln Ala Ser Gln Ala Ile 
        435                 440                 445             


Gly Tyr Leu Leu Gly Met Met Ala Leu Pro Met Ile Ala Gly Pro Pro 
    450                 455                 460                 


Ile Ala Gly Leu Leu Arg Asn Cys Phe Gly Asp Tyr His Val Ala Phe 
465                 470                 475                 480 


Tyr Phe Ala Gly Val Pro Pro Ile Ile Gly Ala Val Ile Leu Phe Phe 
                485                 490                 495     


Val Pro Leu Met His Gln Arg Met Phe Lys Lys Glu Gln Arg Asp Ser 
            500                 505                 510         


Ser Lys Asp Lys Met Leu Ala Pro Asp Pro Asp Pro Asn Gly Glu Leu 
        515                 520                 525             


Leu Pro Gly Ser Pro Asn Pro Glu Glu Pro Ile 
    530                 535                 


<210>  3506
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  3506

Met Leu Pro Pro Leu Pro Ser Arg Leu Gly Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Cys Pro Ala His Val Gly Gly Leu Trp Trp Ala Val Gly Ser Pro 
            20                  25                  30          


Leu Val Met Asp Pro Thr Ser Ile Cys Arg Lys Ala Arg Arg Leu Ala 
        35                  40                  45              


Gly Arg Gln Ala Glu Leu Cys Gln Ala Glu Pro Glu Val Val Ala Glu 
    50                  55                  60                  


Leu Ala Arg Gly Ala Arg Leu Gly Val Arg Glu Cys Gln Phe Gln Phe 
65                  70                  75                  80  


Arg Phe Arg Arg Trp Asn Cys Ser Ser His Ser Lys Ala Phe Gly Arg 
                85                  90                  95      


Ile Leu Gln Gln Asp Ile Arg Glu Thr Ala Phe Val Phe Ala Ile Thr 
            100                 105                 110         


Ala Ala Gly Ala Ser His Ala Val Thr Gln Ala Cys Ser Met Gly Glu 
        115                 120                 125             


Leu Leu Gln Cys Gly Cys Gln Ala Pro Arg Gly Arg Ala Pro Pro Arg 
    130                 135                 140                 


Pro Ser Gly Leu Pro Gly Thr Pro Gly Pro Pro Gly Pro Ala Gly Ser 
145                 150                 155                 160 


Pro Glu Gly Ser Ala Ala Trp Glu Trp Gly Gly Cys Gly Asp Asp Val 
                165                 170                 175     


Asp Phe Gly Asp Glu Lys Ser Arg Leu Phe Met Asp Ala Arg His Lys 
            180                 185                 190         


Arg Gly Arg Gly Asp Ile Arg Ala Leu Val Gln Leu His Asn Asn Glu 
        195                 200                 205             


Ala Gly Arg Leu Ala Val Arg Ser His Thr Arg Thr Glu Cys Lys Cys 
    210                 215                 220                 


His Gly Leu Ser Gly Ser Cys Ala Leu Arg Thr Cys Trp Gln Lys Leu 
225                 230                 235                 240 


Pro Pro Phe Arg Glu Val Gly Ala Arg Leu Leu Glu Arg Phe His Gly 
                245                 250                 255     


Ala Ser Arg Val Met Gly Thr Asn Asp Gly Lys Ala Leu Leu Pro Ala 
            260                 265                 270         


Val Arg Thr Leu Lys Pro Pro Gly Arg Ala Asp Leu Leu Tyr Ala Ala 
        275                 280                 285             


Asp Ser Pro Asp Phe Cys Ala Pro Asn Arg Arg Thr Gly Ser Pro Gly 
    290                 295                 300                 


Thr Arg Gly Arg Ala Cys Asn Ser Ser Ala Pro Asp Leu Ser Gly Cys 
305                 310                 315                 320 


Asp Leu Leu Cys Cys Gly Arg Gly His Arg Gln Glu Ser Val Gln Leu 
                325                 330                 335     


Glu Glu Asn Cys Leu Cys Arg Phe His Trp Cys Cys Val Val Gln Cys 
            340                 345                 350         


His Arg Cys Arg Val Arg Lys Glu Leu Ser Leu Cys Leu 
        355                 360                 365 


<210>  3507
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  3507

Met Gly Pro Leu Thr Phe Met Asp Val Ala Ile Glu Phe Ser Leu Glu 
1               5                   10                  15      


Glu Trp Gln Cys Leu Asp Thr Ala Gln Arg Asn Val Tyr Arg His Val 
            20                  25                  30          


Met Leu Glu Asn Tyr Arg Asn Leu Val Phe Leu Ala Leu Cys Ser Arg 
        35                  40                  45              


Phe Ala Gln Asp Leu Trp Leu Glu Gln Asn Ile Lys Asp Ser Phe Gln 
    50                  55                  60                  


Lys Val Thr Leu Ser Arg Tyr Gly Lys Tyr Gly His Lys Asn Leu Gln 
65                  70                  75                  80  


Leu Arg Lys Gly Cys Lys Ser Val Asp Glu Cys Lys Gly His Gln Gly 
                85                  90                  95      


Gly Tyr Asn Gly Leu Asn Gln Cys Leu Lys Ile Thr Thr Ser Lys Ile 
            100                 105                 110         


Phe Gln Cys Asn Lys Tyr Val Lys Val Met His Lys Phe Ser Asn Ser 
        115                 120                 125             


Asn Arg His Lys Ile Arg His Thr Glu Asn Lys His Phe Arg Cys Lys 
    130                 135                 140                 


Glu Cys Asp Lys Ser Leu Cys Met Leu Ser Arg Leu Thr Gln His Lys 
145                 150                 155                 160 


Lys Ile His Thr Arg Glu Asn Phe Tyr Lys Cys Glu Glu Cys Gly Lys 
                165                 170                 175     


Thr Phe Asn Trp Ser Thr Asn Leu Ser Lys Pro Lys Lys Ile His Thr 
            180                 185                 190         


Gly Glu Lys Pro Tyr Lys Cys Glu Val Cys Gly Lys Ala Phe His Gln 
        195                 200                 205             


Ser Ser Ile Leu Thr Lys His Lys Ile Ile Arg Thr Gly Glu Lys Pro 
    210                 215                 220                 


Tyr Lys Cys Ala His Cys Gly Lys Ala Phe Lys Gln Ser Ser His Leu 
225                 230                 235                 240 


Thr Arg His Lys Ile Ile His Thr Glu Glu Lys Pro Tyr Lys Cys Glu 
                245                 250                 255     


Gln Cys Gly Lys Val Phe Lys Gln Ser Pro Thr Leu Thr Lys His Gln 
            260                 265                 270         


Ile Ile Tyr Thr Gly Glu Glu Pro Tyr Lys Cys Glu Glu Cys Gly Lys 
        275                 280                 285             


Ala Phe Asn Leu Ser 
    290             


<210>  3508
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  3508

Met Ala His Val Arg His Phe Arg Thr Leu Val Ser Gly Phe Tyr Phe 
1               5                   10                  15      


Trp Glu Ala Ala Leu Leu Leu Ser Leu Val Ala Thr Lys Glu Thr Asp 
            20                  25                  30          


Ser Ala Arg Ser Arg Ser Ala Pro Met Ser Pro Ser Asp Phe Leu Asp 
        35                  40                  45              


Lys Leu Met Gly Arg Thr Ser Gly Tyr Asp Ala Arg Ile Arg Pro Asn 
    50                  55                  60                  


Phe Lys Gly Pro Pro Val Asn Val Thr Cys Asn Ile Phe Ile Asn Ser 
65                  70                  75                  80  


Phe Gly Ser Ile Ala Glu Thr Thr Met Asp Tyr Arg Val Asn Ile Phe 
                85                  90                  95      


Leu Arg Gln Lys Trp Asn Asp Pro Arg Leu Ala Tyr Ser Glu Tyr Pro 
            100                 105                 110         


Asp Asp Ser Leu Asp Leu Asp Pro Ser Met Leu Asp Ser Ile Trp Lys 
        115                 120                 125             


Pro Asp Leu Phe Phe Ala Asn Glu Lys Gly Ala Asn Phe His Glu Val 
    130                 135                 140                 


Thr Thr Asp Asn Lys Leu Leu Arg Ile Phe Lys Asn Gly Asn Val Leu 
145                 150                 155                 160 


Tyr Ser Ile Arg Leu Thr Leu Thr Leu Ser Cys Pro Met Asp Leu Lys 
                165                 170                 175     


Asn Phe Pro Met Asp Val Gln Thr Cys Ile Met Gln Leu Glu Ser Phe 
            180                 185                 190         


Gly Tyr Thr Met Asn Asp Leu Ile Phe Glu Trp Gln Asp Glu Ala Pro 
        195                 200                 205             


Val Gln Val Ala Glu Gly Leu Thr Leu Pro Gln Phe Leu Leu Lys Glu 
    210                 215                 220                 


Glu Lys Asp Leu Arg Tyr Cys Thr Lys His Tyr Asn Thr Gly Lys Phe 
225                 230                 235                 240 


Thr Cys Ile Glu Val Arg Phe His Leu Glu Arg Gln Met Gly Tyr Tyr 
                245                 250                 255     


Leu Ile Gln Met Tyr Ile Pro Ser Leu Leu Ile Val Ile Leu Ser Trp 
            260                 265                 270         


Val Ser Phe Trp Ile Asn Met Asp Ala Ala Pro Ala Arg Val Ala Leu 
        275                 280                 285             


Gly Ile Thr Thr Val Leu Thr Met Thr Thr Gln Ser Ser Gly Ser Arg 
    290                 295                 300                 


Ala Ser Leu Pro Lys Val Ser Tyr Val Lys Ala Ile Asp Ile Trp Met 
305                 310                 315                 320 


Ala Val Cys Leu Leu Phe Val Phe Ser Ala Leu Leu Glu Tyr Ala Ala 
                325                 330                 335     


Val Asn Phe Val Ser Arg Gln His Lys Glu Leu Leu Arg Phe Arg Arg 
            340                 345                 350         


Lys Arg Lys Asn Lys Thr Glu Ala Phe Ala Leu Glu Lys Phe Tyr Arg 
        355                 360                 365             


Phe Ser Asp Met Asp Asp Glu Val Arg Glu Ser Arg Phe Ser Phe Thr 
    370                 375                 380                 


Ala Tyr Gly Met Gly Pro Cys Leu Gln Ala Lys Asp Gly Met Thr Pro 
385                 390                 395                 400 


Lys Gly Pro Asn His Pro Val Gln Val Met Pro Lys Ser Pro Asp Glu 
                405                 410                 415     


Met Arg Lys Val Phe Ile Asp Arg Ala Lys Lys Ile Asp Thr Ile Ser 
            420                 425                 430         


Arg Ala Cys Phe Pro Leu Ala Phe Leu Ile Phe Asn Ile Phe Tyr Trp 
        435                 440                 445             


Val Ile Tyr Lys Ile Leu Arg His Glu Asp Ile His Gln Gln Gln Asp 
    450                 455                 460                 


<210>  3509
<211>  943
<212>  PRT
<213>  Homo sapiens

<400>  3509

Met Thr Gln Arg Ser Ile Ala Gly Pro Ile Cys Asn Leu Lys Phe Val 
1               5                   10                  15      


Thr Leu Leu Val Ala Leu Ser Ser Glu Leu Pro Phe Leu Gly Ala Gly 
            20                  25                  30          


Val Gln Leu Gln Asp Asn Gly Tyr Asn Gly Leu Leu Ile Ala Ile Asn 
        35                  40                  45              


Pro Gln Val Pro Glu Asn Gln Asn Leu Ile Ser Asn Ile Lys Glu Met 
    50                  55                  60                  


Ile Thr Glu Ala Ser Phe Tyr Leu Phe Asn Ala Thr Lys Arg Arg Val 
65                  70                  75                  80  


Phe Phe Arg Asn Ile Lys Ile Leu Ile Pro Ala Thr Trp Lys Ala Asn 
                85                  90                  95      


Asn Asn Ser Lys Ile Lys Gln Glu Ser Tyr Glu Lys Ala Asn Val Ile 
            100                 105                 110         


Val Thr Asp Trp Tyr Gly Ala His Gly Asp Asp Pro Tyr Thr Leu Gln 
        115                 120                 125             


Tyr Arg Gly Cys Gly Lys Glu Gly Lys Tyr Ile His Phe Thr Pro Asn 
    130                 135                 140                 


Phe Leu Leu Asn Asp Asn Leu Thr Ala Gly Tyr Gly Ser Arg Gly Arg 
145                 150                 155                 160 


Val Phe Val His Glu Trp Ala His Leu Arg Trp Gly Val Phe Asp Glu 
                165                 170                 175     


Tyr Asn Asn Asp Lys Pro Phe Tyr Ile Asn Gly Gln Asn Gln Ile Lys 
            180                 185                 190         


Val Thr Arg Cys Ser Ser Asp Ile Thr Gly Ile Phe Val Cys Glu Lys 
        195                 200                 205             


Gly Pro Cys Pro Gln Glu Asn Cys Ile Ile Ser Lys Leu Phe Lys Glu 
    210                 215                 220                 


Gly Cys Thr Phe Ile Tyr Asn Ser Thr Gln Asn Ala Thr Ala Ser Ile 
225                 230                 235                 240 


Met Phe Met Gln Ser Leu Ser Ser Val Val Glu Phe Cys Asn Ala Ser 
                245                 250                 255     


Thr His Asn Gln Glu Ala Pro Asn Leu Gln Asn Gln Met Cys Ser Leu 
            260                 265                 270         


Arg Ser Ala Trp Asp Val Ile Thr Asp Ser Ala Asp Phe His His Ser 
        275                 280                 285             


Phe Pro Met Asn Gly Thr Glu Leu Pro Pro Pro Pro Thr Phe Ser Leu 
    290                 295                 300                 


Val Gln Ala Gly Asp Lys Val Val Cys Leu Val Leu Asp Val Ser Ser 
305                 310                 315                 320 


Lys Met Ala Glu Ala Asp Arg Leu Leu Gln Leu Gln Gln Ala Ala Glu 
                325                 330                 335     


Phe Tyr Leu Met Gln Ile Val Glu Ile His Thr Phe Val Gly Ile Ala 
            340                 345                 350         


Ser Phe Asp Ser Lys Gly Glu Ile Arg Ala Gln Leu His Gln Ile Asn 
        355                 360                 365             


Ser Asn Asp Asp Arg Lys Leu Leu Val Ser Tyr Leu Pro Thr Thr Val 
    370                 375                 380                 


Ser Ala Lys Thr Asp Ile Ser Ile Cys Ser Gly Leu Lys Lys Gly Phe 
385                 390                 395                 400 


Glu Val Val Glu Lys Leu Asn Gly Lys Ala Tyr Gly Ser Val Met Ile 
                405                 410                 415     


Leu Val Thr Ser Gly Asp Asp Lys Leu Leu Gly Asn Cys Leu Pro Thr 
            420                 425                 430         


Val Leu Ser Ser Gly Ser Thr Ile His Ser Ile Ala Leu Gly Ser Ser 
        435                 440                 445             


Ala Ala Pro Asn Leu Glu Glu Leu Ser Arg Leu Thr Gly Gly Leu Lys 
    450                 455                 460                 


Phe Phe Val Pro Asp Ile Ser Asn Ser Asn Ser Met Ile Asp Ala Phe 
465                 470                 475                 480 


Ser Arg Ile Ser Ser Gly Thr Gly Asp Ile Phe Gln Gln His Ile Gln 
                485                 490                 495     


Leu Glu Ser Thr Gly Glu Asn Val Lys Pro His His Gln Leu Lys Asn 
            500                 505                 510         


Thr Val Thr Val Asp Asn Thr Val Gly Asn Asp Thr Met Phe Leu Val 
        515                 520                 525             


Thr Trp Gln Ala Ser Gly Pro Pro Glu Ile Ile Leu Phe Asp Pro Asp 
    530                 535                 540                 


Gly Arg Lys Tyr Tyr Thr Asn Asn Phe Ile Thr Asn Leu Thr Phe Arg 
545                 550                 555                 560 


Thr Ala Ser Leu Trp Ile Pro Gly Thr Ala Lys Pro Gly His Trp Thr 
                565                 570                 575     


Tyr Thr Leu Asn Asn Thr His His Ser Leu Gln Ala Leu Lys Val Thr 
            580                 585                 590         


Val Thr Ser Arg Ala Ser Asn Ser Ala Val Pro Pro Ala Thr Val Glu 
        595                 600                 605             


Ala Phe Val Glu Arg Asp Ser Leu His Phe Pro His Pro Val Met Ile 
    610                 615                 620                 


Tyr Ala Asn Val Lys Gln Gly Phe Tyr Pro Ile Leu Asn Ala Thr Val 
625                 630                 635                 640 


Thr Ala Thr Val Glu Pro Glu Thr Gly Asp Pro Val Thr Leu Arg Leu 
                645                 650                 655     


Leu Asp Asp Gly Ala Gly Ala Asp Val Ile Lys Asn Asp Gly Ile Tyr 
            660                 665                 670         


Ser Arg Tyr Phe Phe Ser Phe Ala Ala Asn Gly Arg Tyr Ser Leu Lys 
        675                 680                 685             


Val His Val Asn His Ser Pro Ser Ile Ser Thr Pro Ala His Ser Ile 
    690                 695                 700                 


Pro Gly Ser His Ala Met Tyr Val Pro Gly Tyr Thr Ala Asn Gly Asn 
705                 710                 715                 720 


Ile Gln Met Asn Ala Pro Arg Lys Ser Val Gly Arg Asn Glu Glu Glu 
                725                 730                 735     


Arg Lys Trp Gly Phe Ser Arg Val Ser Ser Gly Gly Ser Phe Ser Val 
            740                 745                 750         


Leu Gly Val Pro Ala Gly Pro His Pro Asp Val Phe Pro Pro Cys Lys 
        755                 760                 765             


Ile Ile Asp Leu Glu Ala Val Lys Val Glu Glu Glu Leu Thr Leu Ser 
    770                 775                 780                 


Trp Thr Ala Pro Gly Glu Asp Phe Asp Gln Gly Gln Ala Thr Ser Tyr 
785                 790                 795                 800 


Glu Ile Arg Met Ser Lys Ser Leu Gln Asn Ile Gln Asp Asp Phe Asn 
                805                 810                 815     


Asn Ala Ile Leu Val Asn Thr Ser Lys Arg Asn Pro Gln Gln Ala Gly 
            820                 825                 830         


Ile Arg Glu Ile Phe Thr Phe Ser Pro Gln Ile Ser Thr Asn Gly Pro 
        835                 840                 845             


Glu His Gln Pro Asn Gly Glu Thr His Glu Ser His Arg Ile Tyr Val 
    850                 855                 860                 


Ala Ile Arg Ala Met Asp Arg Asn Ser Leu Gln Ser Ala Val Ser Asn 
865                 870                 875                 880 


Ile Ala Gln Ala Pro Leu Phe Ile Pro Pro Asn Ser Asp Pro Val Pro 
                885                 890                 895     


Ala Arg Asp Tyr Leu Ile Leu Lys Gly Val Leu Thr Ala Met Gly Leu 
            900                 905                 910         


Ile Gly Ile Ile Cys Leu Ile Ile Val Val Thr His His Thr Leu Ser 
        915                 920                 925             


Arg Lys Lys Arg Ala Asp Lys Lys Glu Asn Gly Thr Lys Leu Leu 
    930                 935                 940             


<210>  3510
<211>  315
<212>  PRT
<213>  Homo sapiens

<400>  3510

Met Arg Met Cys Asp Arg Gly Ile Gln Met Leu Ile Thr Thr Val Gly 
1               5                   10                  15      


Ala Phe Ala Ala Phe Ser Leu Met Thr Ile Ala Val Gly Thr Asp Tyr 
            20                  25                  30          


Trp Leu Tyr Ser Arg Gly Val Cys Arg Thr Lys Ser Thr Ser Asp Asn 
        35                  40                  45              


Glu Thr Ser Arg Lys Asn Glu Glu Val Met Thr His Ser Gly Leu Trp 
    50                  55                  60                  


Arg Thr Cys Cys Leu Glu Gly Ala Phe Arg Gly Val Cys Lys Lys Ile 
65                  70                  75                  80  


Asp His Phe Pro Glu Asp Ala Asp Tyr Glu Gln Asp Thr Ala Glu Tyr 
                85                  90                  95      


Leu Leu Arg Ala Val Arg Ala Ser Ser Val Phe Pro Ile Leu Ser Val 
            100                 105                 110         


Thr Leu Leu Phe Phe Gly Gly Leu Cys Val Ala Ala Ser Glu Phe His 
        115                 120                 125             


Arg Ser Arg His Asn Val Ile Leu Ser Ala Gly Ile Phe Phe Val Ser 
    130                 135                 140                 


Ala Gly Leu Ser Asn Ile Ile Gly Ile Ile Val Tyr Ile Ser Ala Asn 
145                 150                 155                 160 


Ala Gly Asp Pro Gly Gln Arg Asp Ser Lys Lys Ser Tyr Ser Tyr Gly 
                165                 170                 175     


Trp Ser Phe Tyr Phe Gly Ala Phe Ser Phe Ile Ile Ala Glu Ile Val 
            180                 185                 190         


Gly Val Val Ala Val His Ile Tyr Ile Glu Lys His Gln Gln Leu Arg 
        195                 200                 205             


Ala Lys Ser His Ser Glu Phe Leu Lys Lys Ser Thr Phe Ala Arg Leu 
    210                 215                 220                 


Pro Pro Tyr Arg Tyr Arg Phe Arg Arg Arg Ser Ser Ser Arg Ser Thr 
225                 230                 235                 240 


Glu Pro Arg Ser Arg Asp Leu Ser Pro Ile Ser Lys Gly Phe His Thr 
                245                 250                 255     


Ile Pro Ser Thr Asp Ile Ser Met Phe Thr Leu Ser Arg Asp Pro Ser 
            260                 265                 270         


Lys Ile Thr Met Gly Thr Leu Leu Asn Ser Asp Arg Asp His Ala Phe 
        275                 280                 285             


Leu Gln Phe His Asn Ser Thr Pro Lys Glu Phe Lys Glu Ser Leu His 
    290                 295                 300                 


Asn Asn Pro Ala Asn Arg Arg Thr Thr Pro Val 
305                 310                 315 


<210>  3511
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  3511

Met Ala Asp Pro Gln Ala Gly Ser Ala Ala Gly Asp Trp Glu Ile Asp 
1               5                   10                  15      


Val Glu Ser Leu Glu Leu Glu Glu Asp Val Cys Gly Ala Pro Arg Ser 
            20                  25                  30          


Thr Pro Pro Gly Pro Ser Pro Pro Pro Ala Asp Gly Asp Cys Glu Asp 
        35                  40                  45              


Asp Glu Asp Asp Asp Gly Val Asp Glu Asp Ala Glu Glu Glu Gly Asp 
    50                  55                  60                  


Gly Glu Glu Ala Gly Ala Ser Pro Gly Met Pro Gly Gln Pro Glu Gln 
65                  70                  75                  80  


Arg Gly Gly Pro Gln Pro Arg Pro Pro Leu Ala Pro Gln Ala Ser Pro 
                85                  90                  95      


Ala Gly Thr Gly Pro Arg Glu Arg Cys Thr Pro Ala Gly Gly Gly Ala 
            100                 105                 110         


Glu Pro Arg Lys Leu Ser Arg Thr Pro Lys Cys Ala Arg Cys Arg Asn 
        115                 120                 125             


His Gly Val Val Ser Cys Leu Lys Gly His Lys Arg Phe Cys Arg Trp 
    130                 135                 140                 


Arg Asp Cys Gln Cys Ala Asn Cys Leu Leu Val Val Glu Arg Gln Arg 
145                 150                 155                 160 


Val Met Ala Ala Gln Val Ala Leu Arg Arg Gln Gln Ala Thr Glu Asp 
                165                 170                 175     


Lys Lys Gly Leu Ser Gly Lys Gln Asn Asn Phe Glu Arg Lys Ala Val 
            180                 185                 190         


Tyr Gln Arg Gln Val Arg Ala Pro Ser Leu Leu Ala Lys Ser Ile Leu 
        195                 200                 205             


Glu Val Leu Leu Gly Leu Phe Tyr Ser Tyr Tyr Val Tyr Ile Met Asn 
    210                 215                 220                 


His Leu 
225     


<210>  3512
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  3512

Met Ala Glu His Asp Tyr His Glu Asp Tyr Gly Phe Ser Ser Phe Asn 
1               5                   10                  15      


Asp Ser Ser Gln Glu Glu His Gln Asp Phe Leu Gln Phe Ser Lys Val 
            20                  25                  30          


Phe Leu Pro Cys Met Tyr Leu Val Val Phe Val Cys Gly Leu Val Gly 
        35                  40                  45              


Asn Ser Leu Val Leu Val Ile Ser Ile Phe Tyr His Lys Leu Gln Ser 
    50                  55                  60                  


Leu Thr Asp Val Phe Leu Val Asn Leu Pro Leu Ala Asp Leu Val Phe 
65                  70                  75                  80  


Val Cys Thr Leu Pro Phe Trp Ala Tyr Ala Gly Ile His Glu Trp Val 
                85                  90                  95      


Phe Gly Gln Val Met Cys Lys Ser Leu Leu Gly Ile Tyr Thr Ile Asn 
            100                 105                 110         


Phe Tyr Thr Ser Met Leu Ile Leu Thr Cys Ile Thr Val Asp Arg Phe 
        115                 120                 125             


Ile Val Val Val Lys Ala Thr Lys Ala Tyr Asn Gln Gln Ala Lys Arg 
    130                 135                 140                 


Met Thr Trp Gly Lys Val Thr Ser Leu Leu Ile Trp Val Ile Ser Leu 
145                 150                 155                 160 


Leu Val Ser Leu Pro Gln Ile Ile Tyr Gly Asn Val Phe Asn Leu Asp 
                165                 170                 175     


Lys Leu Ile Cys Gly Tyr His Asp Glu Ala Ile Ser Thr Val Val Leu 
            180                 185                 190         


Ala Thr Gln Met Thr Leu Gly Phe Phe Leu Pro Leu Leu Thr Met Ile 
        195                 200                 205             


Val Cys Tyr Ser Val Ile Ile Lys Thr Leu Leu His Ala Gly Gly Phe 
    210                 215                 220                 


Gln Lys His Arg Ser Leu Lys Ile Ile Phe Leu Val Met Ala Val Phe 
225                 230                 235                 240 


Leu Leu Thr Gln Met Pro Phe Asn Leu Met Lys Phe Ile Arg Ser Thr 
                245                 250                 255     


His Trp Glu Tyr Tyr Ala Met Thr Ser Phe His Tyr Thr Ile Met Val 
            260                 265                 270         


Thr Glu Ala Ile Ala Tyr Leu Arg Ala Cys Leu Asn Pro Val Leu Tyr 
        275                 280                 285             


Ala Phe Val Ser Leu Lys Phe Arg Lys Asn Phe Trp Lys Leu Val Lys 
    290                 295                 300                 


Asp Ile Gly Cys Leu Pro Tyr Leu Gly Val Ser His Gln Trp Lys Ser 
305                 310                 315                 320 


Ser Glu Asp Asn Ser Lys Thr Phe Ser Ala Ser His Asn Val Glu Ala 
                325                 330                 335     


Thr Ser Met Phe Gln Leu 
            340         


<210>  3513
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  3513

Met Asp Tyr Pro Thr Leu Leu Leu Ala Leu Leu His Val Tyr Arg Ala 
1               5                   10                  15      


Leu Cys Glu Glu Val Leu Trp His Thr Ser Val Pro Phe Ala Glu Asn 
            20                  25                  30          


Met Ser Leu Glu Cys Val Tyr Pro Ser Met Gly Ile Leu Thr Gln Val 
        35                  40                  45              


Glu Trp Phe Lys Ile Gly Thr Gln Gln Asp Ser Ile Ala Ile Phe Ser 
    50                  55                  60                  


Pro Thr His Gly Met Val Ile Arg Lys Pro Tyr Ala Glu Arg Val Tyr 
65                  70                  75                  80  


Phe Leu Asn Ser Thr Met Ala Ser Asn Asn Met Thr Leu Phe Phe Arg 
                85                  90                  95      


Asn Ala Ser Glu Asp Asp Val Gly Tyr Tyr Ser Cys Ser Leu Tyr Thr 
            100                 105                 110         


Tyr Pro Gln Gly Thr Trp Gln Lys Val Ile Gln Val Val Gln Ser Asp 
        115                 120                 125             


Ser Phe Glu Ala Ala Val Pro Ser Asn Ser His Ile Val Ser Glu Pro 
    130                 135                 140                 


Gly Lys Asn Val Thr Leu Thr Cys Gln Pro Gln Met Thr Trp Pro Val 
145                 150                 155                 160 


Gln Ala Val Arg Trp Glu Lys Ile Gln Pro Arg Gln Ile Asp Leu Leu 
                165                 170                 175     


Thr Tyr Cys Asn Leu Val His Gly Arg Asn Phe Thr Ser Lys Phe Pro 
            180                 185                 190         


Arg Gln Ile Val Ser Asn Cys Ser His Gly Arg Trp Ser Val Ile Val 
        195                 200                 205             


Ile Pro Asp Val Thr Val Ser Asp Ser Gly Leu Tyr Arg Cys Tyr Leu 
    210                 215                 220                 


Gln Ala Ser Ala Gly Glu Asn Glu Thr Phe Val Met Arg Leu Thr Val 
225                 230                 235                 240 


Ala Glu Gly Lys Thr Asp Asn Gln Tyr Thr Leu Phe Val Ala Gly Gly 
                245                 250                 255     


Thr Val Leu Leu Leu Leu Phe Val Ile Ser Ile Thr Thr Ile Ile Val 
            260                 265                 270         


Ile Phe Leu Asn Arg Arg Arg Arg Arg Glu Arg Arg Asp Leu Phe Thr 
        275                 280                 285             


Glu Ser Trp Asp Thr Gln Lys Ala Pro Asn Asn Tyr Arg Ser Pro Ile 
    290                 295                 300                 


Ser Thr Ser Gln Pro Thr Asn Gln Ser Met Asp Asp Thr Arg Glu Asp 
305                 310                 315                 320 


Ile Tyr Val Asn Tyr Pro Thr Phe Ser Arg Arg Pro Lys Thr Arg Val 
                325                 330                 335     


<210>  3514
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  3514

Met Ala Ala Val Phe Leu Val Thr Leu Tyr Glu Tyr Ser Pro Leu Phe 
1               5                   10                  15      


Tyr Ile Ala Val Val Phe Thr Cys Phe Ile Val Thr Thr Gly Leu Val 
            20                  25                  30          


Leu Gly Trp Phe Gly Trp Asp Val Pro Val Ile Leu Arg Asn Ser Glu 
        35                  40                  45              


Glu Thr Gln Phe Ser Thr Arg Val Phe Lys Lys Gln Met Arg Gln Val 
    50                  55                  60                  


Lys Asn Pro Phe Gly Leu Glu Ile Thr Asn Pro Ser Ser Ala Ser Ile 
65                  70                  75                  80  


Thr Thr Gly Ile Thr Leu Thr Thr Asp Cys Leu Glu Asp Ser Leu Leu 
                85                  90                  95      


Thr Cys Tyr Trp Gly Cys Ser Val Gln Lys Leu Tyr Glu Ala Leu Gln 
            100                 105                 110         


Lys His Val Tyr Cys Phe Arg Ile Ser Thr Pro Gln Ala Leu Glu Asp 
        115                 120                 125             


Ala Leu Tyr Ser Glu Tyr Leu Tyr Gln Glu Gln Tyr Phe Ile Lys Lys 
    130                 135                 140                 


Asp Ser Lys Glu Glu Ile Tyr Cys Gln Leu Pro Arg Asp Thr Lys Ile 
145                 150                 155                 160 


Glu Asp Phe Gly Thr Val Pro Arg Ser Arg Tyr Pro Leu Val Ala Leu 
                165                 170                 175     


Leu Thr Leu Ala Asp Glu Asp Asp Arg Glu Ile Tyr Asp Ile Ile Ser 
            180                 185                 190         


Met Val Ser Val Ile His Ile Pro Asp Arg Thr Tyr Lys Leu Ser Cys 
        195                 200                 205             


Arg Ile Leu Tyr Gln Tyr Leu Leu Leu Ala Gln Gly Gln Phe His Asp 
    210                 215                 220                 


Leu Lys Gln Leu Phe Met Ser Ala Asn Asn Asn Phe Thr Pro Ser Asn 
225                 230                 235                 240 


Asn Ser Ser Ser Glu Glu Lys Asn Thr Asp Arg Ser Leu Leu Glu Lys 
                245                 250                 255     


Val Gly Leu Ser Glu Ser Glu Val Glu Pro Ser Glu Glu Asn Ser Lys 
            260                 265                 270         


Asp Cys Val Val Cys Gln Asn Gly Thr Val Asn Trp Val Leu Leu Pro 
        275                 280                 285             


Cys Arg His Thr Cys Leu Cys Asp Gly Cys Val Lys Tyr Phe Gln Gln 
    290                 295                 300                 


Cys Pro Met Cys Arg Gln Phe Val Gln Glu Ser Phe Ala Leu Cys Ser 
305                 310                 315                 320 


Gln Lys Glu Gln Asp Lys Asp Lys Pro Lys Thr Leu 
                325                 330         


<210>  3515
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  3515

Met Asp Asp Ser Thr Glu Arg Glu Gln Ser Arg Leu Thr Ser Cys Leu 
1               5                   10                  15      


Lys Lys Arg Glu Glu Met Lys Leu Lys Glu Cys Val Ser Ile Leu Pro 
            20                  25                  30          


Arg Lys Glu Ser Pro Ser Val Arg Ser Ser Lys Asp Gly Lys Leu Leu 
        35                  40                  45              


Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Cys Cys Leu Thr Val Val 
    50                  55                  60                  


Ser Phe Tyr Gln Val Ala Ala Leu Gln Gly Asp Leu Ala Ser Leu Arg 
65                  70                  75                  80  


Ala Glu Leu Gln Gly His His Ala Glu Lys Leu Pro Ala Gly Ala Gly 
                85                  90                  95      


Ala Pro Lys Ala Gly Leu Glu Glu Ala Pro Ala Val Thr Ala Gly Leu 
            100                 105                 110         


Lys Ile Phe Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Asn 
        115                 120                 125             


Ser Arg Asn Lys Arg Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln 
    130                 135                 140                 


Asp Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys 
145                 150                 155                 160 


Gly Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser 
                165                 170                 175     


Ala Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr 
            180                 185                 190         


Phe Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met 
        195                 200                 205             


Gly His Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu 
    210                 215                 220                 


Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu 
225                 230                 235                 240 


Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly 
                245                 250                 255     


Asp Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu 
            260                 265                 270         


Asp Gly Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu 
        275                 280                 285 


<210>  3516
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  3516

Met Gly Arg Ala Gly Gly Gly Gly Pro Gly Arg Gly Pro Pro Pro Leu 
1               5                   10                  15      


Leu Leu Phe Leu Gly Ala Ala Leu Val Leu Ala Ser Gly Ala Val Pro 
            20                  25                  30          


Ala Arg Glu Ala Gly Ser Ala Val Glu Ala Glu Glu Leu Val Lys Gly 
        35                  40                  45              


Ser Pro Ala Trp Glu Pro Pro Ala Asn Asp Thr Arg Glu Glu Ala Gly 
    50                  55                  60                  


Pro Pro Ala Ala Gly Glu Asp Glu Ala Ser Trp Thr Ala Pro Gly Gly 
65                  70                  75                  80  


Glu Leu Ala Gly Pro Glu Glu Val Leu Gln Glu Ser Ala Ala Val Thr 
                85                  90                  95      


Gly Thr Ala Trp Leu Glu Ala Asp Ser Pro Gly Leu Gly Gly Val Thr 
            100                 105                 110         


Ala Glu Ala Gly Ser Gly Asp Ala Gln Ala Leu Pro Ala Thr Leu Gln 
        115                 120                 125             


Ala Pro His Glu Val Leu Gly Gln Ser Ile Met Pro Pro Ala Ile Pro 
    130                 135                 140                 


Glu Ala Thr Glu Ala Ser Gly Pro Pro Ser Pro Thr Pro Gly Asp Lys 
145                 150                 155                 160 


Leu Ser Pro Ala Ser Glu Leu Pro Lys Glu Ser Pro Leu Glu Val Trp 
                165                 170                 175     


Leu Asn Leu Gly Gly Ser Thr Pro Asp Pro Gln Gly Pro Glu Leu Thr 
            180                 185                 190         


Tyr Pro Phe Gln Gly Thr Leu Glu Pro Gln Pro Ala Ser Asp Ile Ile 
        195                 200                 205             


Asp Ile Asp Tyr Phe Glu Gly Leu Asp Gly Glu Gly Arg Gly Ala Asp 
    210                 215                 220                 


Leu Gly Ser Phe Pro Gly Ser Pro Gly Thr Ser Glu Asn His Pro Asp 
225                 230                 235                 240 


Thr Glu Gly Glu Thr Pro Ser Trp Ser Leu Leu Asp Leu Tyr Asp Asp 
                245                 250                 255     


Phe Thr Pro Phe Asp Glu Ser Asp Phe Tyr Pro Thr Thr Ser Phe Tyr 
            260                 265                 270         


Asp Asp Leu Asp Glu Glu Glu Glu Glu Glu Glu Asp Asp Lys Asp Ala 
        275                 280                 285             


Val Gly Gly Gly Asp Leu Glu Asp Glu Asn Glu Leu Leu Val Pro Thr 
    290                 295                 300                 


Gly Lys Pro Gly Leu Gly Pro Gly Thr Gly Gln Pro Thr Ser Arg Trp 
305                 310                 315                 320 


His Ala Val Pro Pro Gln His Thr Leu Gly Ser Val Pro Gly Ser Ser 
                325                 330                 335     


Ile Ala Leu Arg Pro Arg Pro Gly Glu Pro Gly Arg Asp Leu Ala Ser 
            340                 345                 350         


Ser Glu Asn Gly Thr Glu Cys Arg Ser Gly Phe Val Arg His Asn Gly 
        355                 360                 365             


Ser Cys Arg Ser Val Cys Asp Leu Phe Pro Ser Tyr Cys His Asn Gly 
    370                 375                 380                 


Gly Gln Cys Tyr Leu Val Glu Asn Ile Gly Ala Phe Cys Arg Cys Asn 
385                 390                 395                 400 


Thr Gln Asp Tyr Ile Trp His Lys Gly Met Arg Cys Glu Ser Ile Ile 
                405                 410                 415     


Thr Asp Phe Gln Val Met Cys Val Ala Val Gly Ser Ala Ala Leu Val 
            420                 425                 430         


Leu Leu Leu Leu Phe Met Met Thr Val Phe Phe Ala Lys Lys Leu Tyr 
        435                 440                 445             


Leu Leu Lys Thr Glu Asn Thr Lys Leu Arg Arg Thr Asn Lys Phe Arg 
    450                 455                 460                 


Thr Pro Ser Glu Leu His Asn Asp Asn Phe Ser Leu Ser Thr Ile Ala 
465                 470                 475                 480 


Glu Gly Ser His Pro Asn Asp Asp Pro Ser Ala Pro His Lys Ile Gln 
                485                 490                 495     


Glu Val Leu Lys Ser Cys Leu Lys Glu Glu Glu Ser Phe Asn Ile Gln 
            500                 505                 510         


Asn Ser Met Ser Pro Lys Leu Glu Gly Gly Lys Gly Asp Gln Ala Asp 
        515                 520                 525             


Leu Asp Val Asn Cys Leu Gln Asn Asn Leu Thr 
    530                 535                 


<210>  3517
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  3517

Met Gln Met Ser Tyr Ala Ile Arg Cys Ala Phe Tyr Gln Leu Leu Leu 
1               5                   10                  15      


Ala Ala Leu Met Leu Val Ala Met Leu Gln Leu Leu Tyr Leu Ser Leu 
            20                  25                  30          


Leu Ser Gly Leu His Gly Gln Glu Glu Gln Asp Gln Tyr Phe Glu Phe 
        35                  40                  45              


Phe Pro Pro Ser Pro Arg Ser Val Asp Gln Val Lys Ala Gln Leu Arg 
    50                  55                  60                  


Thr Ala Leu Ala Ser Gly Gly Val Leu Asp Ala Ser Gly Asp Tyr Arg 
65                  70                  75                  80  


Val Tyr Arg Gly Leu Leu Lys Thr Thr Met Asp Pro Asn Asp Val Ile 
                85                  90                  95      


Leu Ala Thr His Ala Ser Val Asp Asn Leu Leu His Leu Ser Gly Leu 
            100                 105                 110         


Leu Glu Arg Trp Glu Gly Pro Leu Ser Val Ser Val Phe Ala Ala Thr 
        115                 120                 125             


Lys Glu Glu Ala Gln Leu Ala Thr Val Leu Ala Tyr Ala Leu Ser Ser 
    130                 135                 140                 


His Cys Pro Asp Met Arg Ala Arg Val Ala Met His Leu Val Cys Pro 
145                 150                 155                 160 


Ser Arg Tyr Glu Ala Ala Val Pro Asp Pro Arg Glu Pro Gly Glu Phe 
                165                 170                 175     


Ala Leu Leu Arg Ser Cys Gln Glu Val Phe Asp Lys Leu Ala Arg Val 
            180                 185                 190         


Ala Gln Pro Gly Ile Asn Tyr Ala Leu Gly Thr Asn Val Ser Tyr Pro 
        195                 200                 205             


Asn Asn Leu Leu Arg Asn Leu Ala Arg Glu Gly Ala Asn Tyr Ala Leu 
    210                 215                 220                 


Val Ile Asp Val Asp Met Val Pro Ser Glu Gly Leu Trp Arg Gly Leu 
225                 230                 235                 240 


Arg Glu Met Leu Asp Gln Ser Asn Gln Trp Gly Gly Thr Ala Leu Val 
                245                 250                 255     


Val Pro Ala Phe Glu Ile Arg Arg Ala Arg Arg Met Pro Met Asn Lys 
            260                 265                 270         


Asn Glu Leu Val Gln Leu Tyr Gln Val Gly Glu Val Arg Pro Phe Tyr 
        275                 280                 285             


Tyr Gly Leu Cys Thr Pro Cys Gln Ala Pro Thr Asn Tyr Ser Arg Trp 
    290                 295                 300                 


Val Asn Leu Pro Glu Glu Ser Leu Leu Arg Pro Ala Tyr Val Val Pro 
305                 310                 315                 320 


Trp Gln Asp Pro Trp Glu Pro Phe Tyr Val Ala Gly Gly Lys Val Pro 
                325                 330                 335     


Thr Phe Asp Glu Arg Phe Arg Gln Tyr Gly Phe Asn Arg Ile Ser Gln 
            340                 345                 350         


Ala Cys Glu Leu His Val Ala Gly Phe Asp Phe Glu Val Leu Asn Glu 
        355                 360                 365             


Gly Phe Leu Val His Lys Gly Phe Lys Glu Ala Leu Lys Phe His Pro 
    370                 375                 380                 


Gln Lys Glu Ala Glu Asn Gln His Asn Lys Ile Leu Tyr Arg Gln Phe 
385                 390                 395                 400 


Lys Gln Glu Leu Lys Ala Lys Tyr Pro Asn Ser Pro Arg Arg Cys 
                405                 410                 415 


<210>  3518
<211>  397
<212>  PRT
<213>  Homo sapiens

<400>  3518

Met Ser Val Gly Arg Arg Arg Ile Lys Leu Leu Gly Ile Leu Met Met 
1               5                   10                  15      


Ala Asn Val Phe Ile Tyr Phe Ile Met Glu Val Ser Lys Ser Ser Ser 
            20                  25                  30          


Gln Glu Lys Asn Gly Lys Gly Glu Val Ile Ile Pro Lys Glu Lys Phe 
        35                  40                  45              


Trp Lys Ile Ser Thr Pro Pro Glu Ala Tyr Trp Asn Arg Glu Gln Glu 
    50                  55                  60                  


Lys Leu Asn Arg Gln Tyr Asn Pro Ile Leu Ser Met Leu Thr Asn Gln 
65                  70                  75                  80  


Thr Gly Glu Ala Gly Arg Leu Ser Asn Ile Ser His Leu Asn Tyr Cys 
                85                  90                  95      


Glu Pro Asp Leu Arg Val Thr Ser Val Val Thr Gly Phe Asn Asn Leu 
            100                 105                 110         


Pro Asp Arg Phe Lys Asp Phe Leu Leu Tyr Leu Arg Cys Arg Asn Tyr 
        115                 120                 125             


Ser Leu Leu Ile Asp Gln Pro Asp Lys Cys Ala Lys Lys Pro Phe Leu 
    130                 135                 140                 


Leu Leu Ala Ile Lys Ser Leu Thr Pro His Phe Ala Arg Arg Gln Ala 
145                 150                 155                 160 


Ile Arg Glu Ser Trp Gly Gln Glu Ser Asn Ala Gly Asn Gln Thr Val 
                165                 170                 175     


Val Arg Val Phe Leu Leu Gly Gln Thr Pro Pro Glu Asp Asn His Pro 
            180                 185                 190         


Asp Leu Ser Asp Met Leu Lys Phe Glu Ser Glu Lys His Gln Asp Ile 
        195                 200                 205             


Leu Met Trp Asn Tyr Arg Asp Thr Phe Phe Asn Leu Ser Leu Lys Glu 
    210                 215                 220                 


Val Leu Phe Leu Arg Trp Val Ser Thr Ser Cys Pro Asp Thr Glu Phe 
225                 230                 235                 240 


Val Phe Lys Gly Asp Asp Asp Val Phe Val Asn Thr His His Ile Leu 
                245                 250                 255     


Asn Tyr Leu Asn Ser Leu Ser Lys Thr Lys Ala Lys Asp Leu Phe Ile 
            260                 265                 270         


Gly Asp Val Ile His Asn Ala Gly Pro His Arg Asp Lys Lys Leu Lys 
        275                 280                 285             


Tyr Tyr Ile Pro Glu Val Val Tyr Ser Gly Leu Tyr Pro Pro Tyr Ala 
    290                 295                 300                 


Gly Gly Gly Gly Phe Leu Tyr Ser Gly His Leu Ala Leu Arg Leu Tyr 
305                 310                 315                 320 


His Ile Thr Asp Gln Val His Leu Tyr Pro Ile Asp Asp Val Tyr Thr 
                325                 330                 335     


Gly Met Cys Leu Gln Lys Leu Gly Leu Val Pro Glu Lys His Lys Gly 
            340                 345                 350         


Phe Arg Thr Phe Asp Ile Glu Glu Lys Asn Lys Asn Asn Ile Cys Ser 
        355                 360                 365             


Tyr Val Asp Leu Met Leu Val His Ser Arg Lys Pro Gln Glu Met Ile 
    370                 375                 380                 


Asp Ile Trp Ser Gln Leu Gln Ser Ala His Leu Lys Cys 
385                 390                 395         


<210>  3519
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  3519

Met Thr Thr Asn Ala Gly Pro Leu His Pro Tyr Trp Pro Gln His Leu 
1               5                   10                  15      


Arg Leu Asp Asn Phe Val Pro Asn Asp Arg Pro Thr Trp His Ile Leu 
            20                  25                  30          


Ala Gly Leu Phe Ser Val Thr Gly Val Leu Val Val Thr Thr Trp Leu 
        35                  40                  45              


Leu Ser Gly Arg Ala Ala Val Val Pro Leu Gly Thr Trp Arg Arg Leu 
    50                  55                  60                  


Ser Leu Cys Trp Phe Ala Val Cys Gly Phe Ile His Leu Val Ile Glu 
65                  70                  75                  80  


Gly Trp Phe Val Leu Tyr Tyr Glu Asp Leu Leu Gly Asp Gln Ala Phe 
                85                  90                  95      


Leu Ser Gln Leu Trp Lys Glu Tyr Ala Lys Gly Asp Ser Arg Tyr Ile 
            100                 105                 110         


Leu Gly Asp Asn Phe Thr Val Cys Met Glu Thr Ile Thr Ala Cys Leu 
        115                 120                 125             


Trp Gly Pro Leu Ser Leu Trp Val Val Ile Ala Phe Leu Arg Gln His 
    130                 135                 140                 


Pro Leu Arg Phe Ile Leu Gln Leu Val Val Ser Val Gly Gln Ile Tyr 
145                 150                 155                 160 


Gly Asp Val Leu Tyr Phe Leu Thr Glu His Arg Asp Gly Phe Gln His 
                165                 170                 175     


Gly Glu Leu Gly His Pro Leu Tyr Phe Trp Phe Tyr Phe Val Phe Met 
            180                 185                 190         


Asn Ala Leu Trp Leu Val Leu Pro Gly Val Leu Val Leu Asp Ala Val 
        195                 200                 205             


Lys His Leu Thr His Ala Gln Ser Thr Leu Asp Ala Lys Ala Thr Lys 
    210                 215                 220                 


Ala Lys Ser Lys Lys Asn 
225                 230 


<210>  3520
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  3520

Met Thr Ser Arg Thr Pro Leu Leu Val Thr Ala Cys Leu Tyr Tyr Ser 
1               5                   10                  15      


Tyr Cys Asn Ser Arg His Leu Gln Gln Gly Val Arg Lys Ser Lys Arg 
            20                  25                  30          


Pro Val Phe Ser His Cys Gln Val Pro Glu Thr Gln Lys Thr Asp Thr 
        35                  40                  45              


Arg His Leu Ser Gly Ala Arg Ala Gly Val Cys Pro Cys Cys His Pro 
    50                  55                  60                  


Asp Gly Leu Leu Ala Thr Met Arg Asp Leu Leu Gln Tyr Ile Ala Cys 
65                  70                  75                  80  


Phe Phe Ala Phe Phe Ser Ala Gly Phe Leu Ile Val Ala Thr Trp Thr 
                85                  90                  95      


Asp Cys Trp Met Val Asn Ala Asp Asp Ser Leu Glu Val Ser Thr Lys 
            100                 105                 110         


Cys Arg Gly Leu Trp Trp Glu Cys Val Thr Asn Ala Phe Asp Gly Ile 
        115                 120                 125             


Arg Thr Cys Asp Glu Tyr Asp Ser Ile Leu Ala Glu His Pro Leu Lys 
    130                 135                 140                 


Leu Val Val Thr Arg Ala Leu Met Ile Thr Ala Asp Ile Leu Ala Gly 
145                 150                 155                 160 


Phe Gly Phe Leu Thr Leu Leu Leu Gly Leu Asp Cys Val Lys Phe Leu 
                165                 170                 175     


Pro Asp Glu Pro Tyr Ile Lys Val Arg Ile Cys Phe Val Ala Gly Ala 
            180                 185                 190         


Thr Leu Leu Ile Ala Gly Thr Pro Gly Ile Ile Gly Ser Val Trp Tyr 
        195                 200                 205             


Ala Val Asp Val Tyr Val Glu Arg Ser Thr Leu Val Leu His Asn Ile 
    210                 215                 220                 


Phe Leu Gly Ile Gln Tyr Lys Phe Gly Trp Ser Cys Trp Leu Gly Met 
225                 230                 235                 240 


Ala Gly Ser Leu Gly Cys Phe Leu Ala Gly Ala Val Leu Thr Cys Cys 
                245                 250                 255     


Leu Tyr Leu Phe Lys Asp Val Gly Pro Glu Arg Asn Tyr Pro Tyr Ser 
            260                 265                 270         


Leu Arg Lys Ala Tyr Ser Ala Ala Gly Val Ser Met Ala Lys Ser Tyr 
        275                 280                 285             


Ser Ala Pro Arg Thr Glu Thr Ala Lys Met Tyr Ala Val Asp Thr Arg 
    290                 295                 300                 


Val 
305 


<210>  3521
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  3521

Met Thr Ser Thr Ser Lys Gly Ile Leu Arg Pro Phe Leu Ile Val Cys 
1               5                   10                  15      


Ile Ile Leu Gly Cys Phe Met Ala Cys Leu Leu Ile Tyr Ile Lys Pro 
            20                  25                  30          


Thr Asn Ser Trp Ile Phe Ser Pro Met Glu Ser Ala Ser Ser Val Leu 
        35                  40                  45              


Lys Met Lys Asn Phe Phe Ser Thr Lys Thr Asp Tyr Phe Asn Glu Thr 
    50                  55                  60                  


Thr Ile Leu Val Trp Val Trp Pro Phe Gly Gln Thr Phe Asp Leu Thr 
65                  70                  75                  80  


Ser Cys Gln Ala Met Phe Asn Ile Gln Gly Cys His Leu Thr Thr Asp 
                85                  90                  95      


Arg Ser Leu Tyr Asn Lys Ser His Ala Val Leu Ile His His Arg Asp 
            100                 105                 110         


Ile Ser Trp Asp Leu Thr Asn Leu Pro Gln Gln Ala Arg Pro Pro Phe 
        115                 120                 125             


Gln Lys Trp Ile Trp Met Asn Leu Glu Ser Pro Thr His Thr Pro Gln 
    130                 135                 140                 


Lys Ser Gly Ile Glu His Leu Phe Asn Leu Thr Leu Thr Tyr Arg Arg 
145                 150                 155                 160 


Asp Ser Asp Ile Gln Val Pro Tyr Gly Phe Leu Thr Val Ser Thr Asn 
                165                 170                 175     


Pro Phe Val Phe Glu Val Pro Ser Lys Glu Lys Leu Val Cys Trp Val 
            180                 185                 190         


Val Ser Asn Trp Asn Pro Glu His Ala Arg Val Lys Tyr Tyr Asn Glu 
        195                 200                 205             


Leu Ser Lys Ser Ile Glu Ile His Thr Tyr Gly Gln Ala Phe Gly Glu 
    210                 215                 220                 


Tyr Val Asn Asp Lys Asn Leu Ile Pro Thr Ile Ser Thr Cys Lys Phe 
225                 230                 235                 240 


Tyr Leu Ser Phe Glu Asn Ser Ile His Lys Asp Tyr Ile Thr Glu Lys 
                245                 250                 255     


Leu Tyr Asn Ala Phe Leu Ala Gly Ser Val Pro Val Val Leu Gly Pro 
            260                 265                 270         


Ser Arg Glu Asn Tyr Glu Asn Tyr Ile Pro Ala Asp Ser Phe Ile His 
        275                 280                 285             


Val Glu Asp Tyr Asn Ser Pro Ser Glu Leu Ala Lys Tyr Leu Lys Glu 
    290                 295                 300                 


Val Asp Lys Asn Asn Lys Leu Tyr Leu Ser Tyr Phe Asn Trp Arg Lys 
305                 310                 315                 320 


Asp Phe Thr Val Asn Leu Pro Arg Phe Trp Glu Ser His Ala Cys Leu 
                325                 330                 335     


Ala Cys Asp His Val Lys Arg His Gln Glu Tyr Lys Ser Val Gly Asn 
            340                 345                 350         


Leu Glu Lys Trp Phe Trp Asn 
        355                 


<210>  3522
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  3522

Met Leu Arg Asn Asn Leu Gly Asn Ser Ser Asp Ser Lys Asn Glu Asp 
1               5                   10                  15      


Gly Ser Val Phe Ser Gln Thr Glu His Asn Ile Val Ala Thr Tyr Leu 
            20                  25                  30          


Ile Met Ala Gly Met Ile Ser Ile Ile Ser Asn Ile Ile Val Leu Gly 
        35                  40                  45              


Ile Phe Ile Lys Tyr Lys Glu Leu Arg Thr Pro Thr Asn Ala Ile Ile 
    50                  55                  60                  


Ile Asn Leu Ala Val Thr Asp Ile Gly Val Ser Ser Ile Gly Tyr Pro 
65                  70                  75                  80  


Met Ser Ala Ala Ser Asp Leu Tyr Gly Ser Trp Lys Phe Gly Tyr Ala 
                85                  90                  95      


Gly Cys Gln Val Tyr Ala Gly Leu Asn Ile Phe Phe Gly Met Ala Ser 
            100                 105                 110         


Ile Gly Leu Leu Thr Val Val Ala Val Asp Arg Tyr Leu Thr Ile Cys 
        115                 120                 125             


Leu Pro Asp Val Gly Arg Arg Met Thr Thr Asn Thr Tyr Ile Gly Leu 
    130                 135                 140                 


Ile Leu Gly Ala Trp Ile Asn Gly Leu Phe Trp Ala Leu Met Pro Ile 
145                 150                 155                 160 


Ile Gly Trp Ala Ser Tyr Ala Pro Asp Pro Thr Gly Ala Thr Cys Thr 
                165                 170                 175     


Ile Asn Trp Arg Lys Asn Asp Arg Ser Phe Val Ser Tyr Thr Met Thr 
            180                 185                 190         


Val Ile Ala Ile Asn Phe Ile Val Pro Leu Thr Val Met Phe Tyr Cys 
        195                 200                 205             


Tyr Tyr His Val Thr Leu Ser Ile Lys His His Thr Thr Ser Asp Cys 
    210                 215                 220                 


Thr Glu Ser Leu Asn Arg Asp Trp Ser Asp Gln Ile Asp Val Thr Lys 
225                 230                 235                 240 


Met Ser Val Ile Met Ile Cys Met Phe Leu Val Ala Trp Ser Pro Tyr 
                245                 250                 255     


Ser Ile Val Cys Leu Trp Ala Ser Phe Gly Asp Pro Lys Lys Ile Pro 
            260                 265                 270         


Pro Pro Met Ala Ile Ile Ala Pro Leu Phe Ala Lys Ser Ser Thr Phe 
        275                 280                 285             


Tyr Asn Pro Cys Ile Tyr Val Val Ala Asn Lys Lys Phe Arg Arg Ala 
    290                 295                 300                 


Met Leu Ala Met Phe Lys Cys Gln Thr His Gln Thr Met Pro Val Thr 
305                 310                 315                 320 


Ser Ile Leu Pro Met Asp Val Ser Gln Asn Pro Leu Ala Ser Gly Arg 
                325                 330                 335     


Ile 
    


<210>  3523
<211>  1042
<212>  PRT
<213>  Homo sapiens

<400>  3523

Met Lys Gln Ser Pro Ala Leu Ala Pro Glu Glu Arg Cys Arg Arg Ala 
1               5                   10                  15      


Gly Ser Pro Lys Pro Val Leu Arg Ala Asp Asp Asn Asn Met Gly Asn 
            20                  25                  30          


Gly Cys Ser Gln Lys Leu Ala Thr Ala Asn Leu Leu Arg Phe Leu Leu 
        35                  40                  45              


Leu Val Leu Ile Pro Cys Ile Cys Ala Leu Val Leu Leu Leu Val Ile 
    50                  55                  60                  


Leu Leu Ser Tyr Val Gly Thr Leu Gln Lys Val Tyr Phe Lys Ser Asn 
65                  70                  75                  80  


Gly Ser Glu Pro Leu Val Thr Asp Gly Glu Ile Gln Gly Ser Asp Val 
                85                  90                  95      


Ile Leu Thr Asn Thr Ile Tyr Asn Gln Ser Thr Val Val Ser Thr Ala 
            100                 105                 110         


His Pro Asp Gln His Val Pro Ala Trp Thr Thr Asp Ala Ser Leu Pro 
        115                 120                 125             


Gly Asp Gln Ser His Arg Asn Thr Ser Ala Cys Met Asn Ile Thr His 
    130                 135                 140                 


Ser Gln Cys Gln Met Leu Pro Tyr His Ala Thr Leu Thr Pro Leu Leu 
145                 150                 155                 160 


Ser Val Val Arg Asn Met Glu Met Glu Lys Phe Leu Lys Phe Phe Thr 
                165                 170                 175     


Tyr Leu His Arg Leu Ser Cys Tyr Gln His Ile Met Leu Phe Gly Cys 
            180                 185                 190         


Thr Leu Ala Phe Pro Glu Cys Ile Ile Asp Gly Asp Asp Ser His Gly 
        195                 200                 205             


Leu Leu Pro Cys Arg Ser Phe Cys Glu Ala Ala Lys Glu Gly Cys Glu 
    210                 215                 220                 


Ser Val Leu Gly Met Val Asn Tyr Ser Trp Pro Asp Phe Leu Arg Cys 
225                 230                 235                 240 


Ser Gln Phe Arg Asn Gln Thr Glu Ser Ser Asn Val Ser Arg Ile Cys 
                245                 250                 255     


Phe Ser Pro Gln Gln Glu Asn Gly Lys Gln Leu Leu Cys Gly Arg Gly 
            260                 265                 270         


Glu Asn Phe Leu Cys Ala Ser Gly Ile Cys Ile Pro Gly Lys Leu Gln 
        275                 280                 285             


Cys Asn Gly Tyr Asn Asp Cys Asp Asp Trp Ser Asp Glu Ala His Cys 
    290                 295                 300                 


Asn Cys Ser Glu Asn Leu Phe His Cys His Thr Gly Lys Cys Leu Asn 
305                 310                 315                 320 


Tyr Ser Leu Val Cys Asp Gly Tyr Asp Asp Cys Gly Asp Leu Ser Asp 
                325                 330                 335     


Glu Gln Asn Cys Asp Cys Asn Pro Thr Thr Glu His Arg Cys Gly Asp 
            340                 345                 350         


Gly Arg Cys Ile Ala Met Glu Trp Val Cys Asp Gly Asp His Asp Cys 
        355                 360                 365             


Val Asp Lys Ser Asp Glu Val Asn Cys Ser Cys His Ser Gln Gly Leu 
    370                 375                 380                 


Val Glu Cys Arg Asn Gly Gln Cys Ile Pro Ser Thr Phe Gln Cys Asp 
385                 390                 395                 400 


Gly Asp Glu Asp Cys Lys Asp Gly Ser Asp Glu Glu Asn Cys Ser Val 
                405                 410                 415     


Ile Gln Thr Ser Cys Gln Glu Gly Asp Gln Arg Cys Leu Tyr Asn Pro 
            420                 425                 430         


Cys Leu Asp Ser Cys Gly Gly Ser Ser Leu Cys Asp Pro Asn Asn Ser 
        435                 440                 445             


Leu Asn Asn Cys Ser Gln Cys Glu Pro Ile Thr Leu Glu Leu Cys Met 
    450                 455                 460                 


Asn Leu Pro Tyr Asn Ser Thr Ser Tyr Pro Asn Tyr Phe Gly His Arg 
465                 470                 475                 480 


Thr Gln Lys Glu Ala Ser Ile Ser Trp Glu Ser Ser Leu Phe Pro Ala 
                485                 490                 495     


Leu Val Gln Thr Asn Cys Tyr Lys Tyr Leu Met Phe Phe Ser Cys Thr 
            500                 505                 510         


Ile Leu Val Pro Lys Cys Asp Val Asn Thr Gly Glu His Ile Pro Pro 
        515                 520                 525             


Cys Arg Ala Leu Cys Glu His Ser Lys Glu Arg Cys Glu Ser Val Leu 
    530                 535                 540                 


Gly Ile Val Gly Leu Gln Trp Pro Glu Asp Thr Asp Cys Ser Gln Phe 
545                 550                 555                 560 


Pro Glu Glu Asn Ser Asp Asn Gln Thr Cys Leu Met Pro Asp Glu Tyr 
                565                 570                 575     


Val Glu Glu Cys Ser Pro Ser His Phe Lys Cys Arg Ser Gly Gln Cys 
            580                 585                 590         


Val Leu Ala Ser Arg Arg Cys Asp Gly Gln Ala Asp Cys Asp Asp Asp 
        595                 600                 605             


Ser Asp Glu Glu Asn Cys Gly Cys Lys Glu Arg Asp Leu Trp Glu Cys 
    610                 615                 620                 


Pro Ser Asn Lys Gln Cys Leu Lys His Thr Val Ile Cys Asp Gly Phe 
625                 630                 635                 640 


Pro Asp Cys Pro Asp Tyr Met Asp Glu Lys Asn Cys Ser Phe Cys Gln 
                645                 650                 655     


Asp Asp Glu Leu Glu Cys Ala Asn His Ala Cys Val Ser Arg Asp Leu 
            660                 665                 670         


Trp Cys Asp Gly Glu Ala Asp Cys Ser Asp Ser Ser Asp Glu Trp Asp 
        675                 680                 685             


Cys Val Thr Leu Ser Ile Asn Val Asn Ser Ser Ser Phe Leu Met Val 
    690                 695                 700                 


His Arg Ala Ala Thr Glu His His Val Cys Ala Asp Gly Trp Gln Glu 
705                 710                 715                 720 


Ile Leu Ser Gln Leu Ala Cys Lys Gln Met Gly Leu Gly Glu Pro Ser 
                725                 730                 735     


Val Thr Lys Leu Ile Gln Glu Gln Glu Lys Glu Pro Arg Trp Leu Thr 
            740                 745                 750         


Leu His Ser Asn Trp Glu Ser Leu Asn Gly Thr Thr Leu His Glu Leu 
        755                 760                 765             


Leu Val Asn Gly Gln Ser Cys Glu Ser Arg Ser Lys Ile Ser Leu Leu 
    770                 775                 780                 


Cys Thr Lys Gln Asp Cys Gly Arg Arg Pro Ala Ala Arg Met Asn Lys 
785                 790                 795                 800 


Arg Ile Leu Gly Gly Arg Thr Ser Arg Pro Gly Arg Trp Pro Trp Gln 
                805                 810                 815     


Cys Ser Leu Gln Ser Glu Pro Ser Gly His Ile Cys Gly Cys Val Leu 
            820                 825                 830         


Ile Ala Lys Lys Trp Val Leu Thr Val Ala His Cys Phe Glu Gly Arg 
        835                 840                 845             


Glu Asn Ala Ala Val Trp Lys Val Val Leu Gly Ile Asn Asn Leu Asp 
    850                 855                 860                 


His Pro Ser Val Phe Met Gln Thr Arg Phe Val Lys Thr Ile Ile Leu 
865                 870                 875                 880 


His Pro Arg Tyr Ser Arg Ala Val Val Asp Tyr Asp Ile Ser Ile Val 
                885                 890                 895     


Glu Leu Ser Glu Asp Ile Ser Glu Thr Gly Tyr Val Arg Pro Val Cys 
            900                 905                 910         


Leu Pro Asn Pro Glu Gln Trp Leu Glu Pro Asp Thr Tyr Cys Tyr Ile 
        915                 920                 925             


Thr Gly Trp Gly His Met Gly Asn Lys Met Pro Phe Lys Leu Gln Glu 
    930                 935                 940                 


Gly Glu Val Arg Ile Ile Ser Leu Glu His Cys Gln Ser Tyr Phe Asp 
945                 950                 955                 960 


Met Lys Thr Ile Thr Thr Arg Met Ile Cys Ala Gly Tyr Glu Ser Gly 
                965                 970                 975     


Thr Val Asp Ser Cys Met Gly Asp Ser Gly Gly Pro Leu Val Cys Glu 
            980                 985                 990         


Lys Pro Gly Gly Arg Trp Thr Leu  Phe Gly Leu Thr Ser  Trp Gly Ser 
        995                 1000                 1005             


Val Cys  Phe Ser Lys Val Leu  Gly Pro Gly Val Tyr  Ser Asn Val 
    1010                 1015                 1020             


Ser Tyr  Phe Val Glu Trp Ile  Lys Arg Gln Ile Tyr  Ile Gln Thr 
    1025                 1030                 1035             


Phe Leu  Leu Asn 
    1040         


<210>  3524
<211>  668
<212>  PRT
<213>  Homo sapiens

<400>  3524

Met Met Pro Ser Pro Ser Asp Ser Ser Arg Ser Leu Thr Ser Arg Pro 
1               5                   10                  15      


Ser Thr Arg Gly Leu Thr His Leu Arg Leu His Arg Pro Trp Leu Gln 
            20                  25                  30          


Ala Leu Leu Thr Leu Gly Leu Val Gln Val Leu Leu Gly Ile Leu Val 
        35                  40                  45              


Val Thr Phe Ser Met Val Ala Ser Ser Val Thr Thr Thr Glu Ser Ile 
    50                  55                  60                  


Lys Arg Ser Cys Pro Ser Trp Ala Gly Phe Ser Leu Ala Phe Ser Gly 
65                  70                  75                  80  


Val Val Gly Ile Val Ser Trp Lys Arg Pro Phe Thr Leu Val Ile Ser 
                85                  90                  95      


Phe Phe Ser Leu Leu Ser Val Leu Cys Val Met Leu Ser Met Ala Gly 
            100                 105                 110         


Ser Val Leu Ser Cys Lys Asn Ala Gln Leu Ala Arg Asp Phe Gln Gln 
        115                 120                 125             


Cys Ser Leu Glu Gly Lys Val Cys Val Cys Cys Pro Ser Val Pro Leu 
    130                 135                 140                 


Leu Arg Pro Cys Pro Glu Ser Gly Gln Glu Leu Lys Val Ala Pro Asn 
145                 150                 155                 160 


Ser Thr Cys Asp Glu Ala Arg Gly Ala Leu Lys Asn Leu Leu Phe Ser 
                165                 170                 175     


Val Cys Gly Leu Thr Ile Cys Ala Ala Ile Ile Cys Thr Leu Ser Ala 
            180                 185                 190         


Ile Val Cys Cys Ile Gln Ile Phe Ser Leu Asp Leu Val His Thr Leu 
        195                 200                 205             


Ala Pro Glu Arg Ser Val Ser Gly Pro Leu Gly Pro Leu Gly Cys Thr 
    210                 215                 220                 


Ser Pro Pro Pro Ala Pro Leu Leu His Thr Met Leu Asp Leu Glu Glu 
225                 230                 235                 240 


Phe Val Pro Pro Val Pro Pro Pro Pro Tyr Tyr Pro Pro Glu Tyr Thr 
                245                 250                 255     


Cys Ser Ser Glu Thr Asp Ala Gln Ser Ile Thr Tyr Asn Gly Ser Met 
            260                 265                 270         


Asp Ser Pro Val Pro Leu Tyr Pro Thr Asp Cys Pro Pro Ser Tyr Glu 
        275                 280                 285             


Ala Val Met Gly Leu Arg Gly Asp Ser Gln Ala Thr Leu Phe Asp Pro 
    290                 295                 300                 


Gln Leu His Asp Gly Ser Cys Ile Cys Glu Arg Val Ala Ser Ile Val 
305                 310                 315                 320 


Asp Val Ser Met Asp Ser Gly Ser Leu Val Leu Ser Ala Ile Gly Asp 
                325                 330                 335     


Leu Pro Gly Gly Ser Ser Pro Ser Glu Asp Ser Cys Leu Leu Glu Leu 
            340                 345                 350         


Gln Gly Ser Val Arg Ser Val Asp Tyr Val Leu Phe Arg Ser Ile Gln 
        355                 360                 365             


Arg Ser Arg Ala Gly Tyr Cys Leu Ser Leu Asp Cys Gly Leu Arg Gly 
    370                 375                 380                 


Pro Phe Glu Glu Ser Pro Leu Pro Arg Arg Pro Pro Arg Ala Ala Arg 
385                 390                 395                 400 


Ser Tyr Ser Cys Ser Ala Pro Glu Ala Pro Pro Pro Leu Gly Ala Pro 
                405                 410                 415     


Thr Ala Ala Arg Ser Cys His Arg Leu Glu Gly Trp Pro Pro Trp Val 
            420                 425                 430         


Gly Pro Cys Phe Pro Glu Leu Arg Arg Arg Val Pro Arg Gly Gly Gly 
        435                 440                 445             


Arg Pro Ala Ala Ala Pro Pro Thr Arg Ala Pro Thr Arg Arg Phe Ser 
    450                 455                 460                 


Asp Ser Ser Gly Ser Leu Thr Pro Pro Gly His Arg Pro Pro His Pro 
465                 470                 475                 480 


Ala Ser Pro Pro Pro Leu Leu Leu Pro Arg Ser His Ser Asp Pro Gly 
                485                 490                 495     


Ile Thr Thr Ser Ser Asp Thr Ala Asp Phe Arg Asp Leu Tyr Thr Lys 
            500                 505                 510         


Val Leu Glu Glu Glu Ala Ala Ser Val Ser Ser Ala Asp Thr Gly Leu 
        515                 520                 525             


Cys Ser Glu Ala Cys Leu Phe Arg Leu Ala Arg Cys Pro Ser Pro Lys 
    530                 535                 540                 


Leu Leu Arg Ala Arg Ser Ala Glu Lys Arg Arg Pro Val Pro Thr Phe 
545                 550                 555                 560 


Gln Lys Val Pro Leu Pro Ser Gly Pro Ala Pro Ala His Ser Leu Gly 
                565                 570                 575     


Asp Leu Lys Gly Ser Trp Pro Gly Arg Gly Leu Val Thr Arg Phe Leu 
            580                 585                 590         


Gln Ile Ser Arg Lys Ala Pro Asp Pro Ser Gly Thr Gly Ala His Gly 
        595                 600                 605             


His Lys Gln Val Pro Arg Ser Leu Trp Gly Arg Pro Gly Arg Glu Ser 
    610                 615                 620                 


Leu His Leu Arg Ser Cys Gly Asp Leu Ser Ser Ser Ser Ser Leu Arg 
625                 630                 635                 640 


Arg Leu Leu Ser Gly Arg Arg Leu Glu Arg Gly Thr Arg Pro His Ser 
                645                 650                 655     


Leu Ser Leu Asn Gly Gly Ser Arg Glu Thr Gly Leu 
            660                 665             


<210>  3525
<211>  1083
<212>  PRT
<213>  Homo sapiens

<400>  3525

Met Pro Thr Asn Phe Thr Val Val Pro Val Glu Ala His Ala Asp Gly 
1               5                   10                  15      


Gly Gly Asp Glu Thr Ala Glu Arg Thr Glu Ala Pro Gly Thr Pro Glu 
            20                  25                  30          


Gly Pro Glu Pro Glu Arg Pro Ser Pro Gly Asp Gly Asn Pro Arg Glu 
        35                  40                  45              


Asn Ser Pro Phe Leu Asn Asn Val Glu Val Glu Gln Glu Ser Phe Phe 
    50                  55                  60                  


Glu Gly Lys Asn Met Ala Leu Phe Glu Glu Glu Met Asp Ser Asn Pro 
65                  70                  75                  80  


Met Val Ser Ser Leu Leu Asn Lys Leu Ala Asn Tyr Thr Asn Leu Ser 
                85                  90                  95      


Gln Gly Val Val Glu His Glu Glu Asp Glu Glu Ser Arg Arg Arg Glu 
            100                 105                 110         


Ala Lys Ala Pro Arg Met Gly Thr Phe Ile Gly Val Tyr Leu Pro Cys 
        115                 120                 125             


Leu Gln Asn Ile Leu Gly Val Ile Leu Phe Leu Arg Leu Thr Trp Ile 
    130                 135                 140                 


Val Gly Val Ala Gly Val Leu Glu Ser Phe Leu Ile Val Ala Met Cys 
145                 150                 155                 160 


Cys Thr Cys Thr Met Leu Thr Ala Ile Ser Met Ser Ala Ile Ala Thr 
                165                 170                 175     


Asn Gly Val Val Pro Ala Gly Gly Ser Tyr Tyr Met Ile Ser Arg Ser 
            180                 185                 190         


Leu Gly Pro Glu Phe Gly Gly Ala Val Gly Leu Cys Phe Tyr Leu Gly 
        195                 200                 205             


Thr Thr Phe Ala Gly Ala Met Tyr Ile Leu Gly Thr Ile Glu Ile Phe 
    210                 215                 220                 


Leu Thr Tyr Ile Ser Pro Gly Ala Ala Ile Phe Gln Ala Glu Ala Ala 
225                 230                 235                 240 


Gly Gly Glu Ala Ala Ala Met Leu His Asn Met Arg Val Tyr Gly Thr 
                245                 250                 255     


Cys Thr Leu Val Leu Met Ala Leu Val Val Phe Val Gly Val Lys Tyr 
            260                 265                 270         


Val Asn Lys Leu Ala Leu Val Phe Leu Ala Cys Val Val Leu Ser Ile 
        275                 280                 285             


Leu Ala Ile Tyr Ala Gly Val Ile Lys Ser Ala Phe Asp Pro Pro Asp 
    290                 295                 300                 


Ile Pro Val Cys Leu Leu Gly Asn Arg Thr Leu Ser Arg Arg Ser Phe 
305                 310                 315                 320 


Asp Ala Cys Val Lys Ala Tyr Gly Ile His Asn Asn Ser Ala Thr Ser 
                325                 330                 335     


Ala Leu Trp Gly Leu Phe Cys Asn Gly Ser Gln Pro Ser Ala Ala Cys 
            340                 345                 350         


Asp Glu Tyr Phe Ile Gln Asn Asn Val Thr Glu Ile Gln Gly Ile Pro 
        355                 360                 365             


Gly Ala Ala Ser Gly Val Phe Leu Glu Asn Leu Trp Ser Thr Tyr Ala 
    370                 375                 380                 


His Ala Gly Ala Phe Val Glu Lys Lys Gly Val Pro Ser Val Pro Val 
385                 390                 395                 400 


Ala Glu Glu Ser Arg Ala Ser Ala Leu Pro Tyr Val Leu Thr Asp Ile 
                405                 410                 415     


Ala Ala Ser Phe Thr Leu Leu Val Gly Ile Tyr Phe Pro Ser Val Thr 
            420                 425                 430         


Gly Ile Met Ala Gly Ser Asn Arg Ser Gly Asp Leu Lys Asp Ala Gln 
        435                 440                 445             


Lys Ser Ile Pro Thr Gly Thr Ile Leu Ala Ile Val Thr Thr Ser Phe 
    450                 455                 460                 


Ile Tyr Leu Ser Cys Ile Val Leu Phe Gly Ala Cys Ile Glu Gly Val 
465                 470                 475                 480 


Val Leu Arg Asp Lys Phe Gly Glu Ala Leu Gln Gly Asn Leu Val Ile 
                485                 490                 495     


Gly Met Leu Ala Trp Pro Ser Pro Trp Val Ile Val Ile Gly Ser Phe 
            500                 505                 510         


Phe Ser Thr Cys Gly Ala Gly Leu Gln Ser Leu Thr Gly Ala Pro Arg 
        515                 520                 525             


Leu Leu Gln Ala Ile Ala Arg Asp Gly Ile Val Pro Phe Leu Gln Val 
    530                 535                 540                 


Phe Gly His Gly Lys Ala Asn Gly Glu Pro Thr Trp Ala Leu Leu Leu 
545                 550                 555                 560 


Thr Val Leu Ile Cys Glu Thr Gly Ile Leu Ile Ala Ser Leu Asp Ser 
                565                 570                 575     


Val Ala Pro Ile Leu Ser Met Phe Phe Leu Met Cys Tyr Leu Phe Val 
            580                 585                 590         


Asn Leu Ala Cys Ala Val Gln Thr Leu Leu Arg Thr Pro Asn Trp Arg 
        595                 600                 605             


Pro Arg Phe Lys Phe Tyr His Trp Thr Leu Ser Phe Leu Gly Met Ser 
    610                 615                 620                 


Leu Cys Leu Ala Leu Met Phe Ile Cys Ser Trp Tyr Tyr Ala Leu Ser 
625                 630                 635                 640 


Ala Met Leu Ile Ala Gly Cys Ile Tyr Lys Tyr Ile Glu Tyr Arg Gly 
                645                 650                 655     


Ala Glu Lys Glu Trp Gly Asp Gly Ile Arg Gly Leu Ser Leu Asn Ala 
            660                 665                 670         


Ala Arg Tyr Ala Leu Leu Arg Val Glu His Gly Pro Pro His Thr Lys 
        675                 680                 685             


Asn Trp Arg Pro Gln Val Leu Val Met Leu Asn Leu Asp Ala Glu Gln 
    690                 695                 700                 


Ala Val Lys His Pro Arg Leu Leu Ser Phe Thr Ser Gln Leu Lys Ala 
705                 710                 715                 720 


Gly Lys Gly Leu Thr Ile Val Gly Ser Val Leu Glu Gly Thr Tyr Leu 
                725                 730                 735     


Asp Lys His Met Glu Ala Gln Arg Ala Glu Glu Asn Ile Arg Ser Leu 
            740                 745                 750         


Met Ser Thr Glu Lys Thr Lys Gly Phe Cys Gln Leu Val Val Ser Ser 
        755                 760                 765             


Ser Leu Arg Asp Gly Met Ser His Leu Ile Gln Ser Ala Gly Leu Gly 
    770                 775                 780                 


Gly Leu Lys His Asn Thr Val Leu Met Ala Trp Pro Ala Ser Trp Lys 
785                 790                 795                 800 


Gln Glu Asp Asn Pro Phe Ser Trp Lys Asn Phe Val Asp Thr Val Arg 
                805                 810                 815     


Asp Thr Thr Ala Ala His Gln Ala Leu Leu Val Ala Lys Asn Val Asp 
            820                 825                 830         


Ser Phe Pro Gln Asn Gln Glu Arg Phe Gly Gly Gly His Ile Asp Val 
        835                 840                 845             


Trp Trp Ile Val His Asp Gly Gly Met Leu Met Leu Leu Pro Phe Leu 
    850                 855                 860                 


Leu Arg Gln His Lys Val Trp Arg Lys Cys Arg Met Arg Ile Phe Thr 
865                 870                 875                 880 


Val Ala Gln Val Asp Asp Asn Ser Ile Gln Met Lys Lys Asp Leu Gln 
                885                 890                 895     


Met Phe Leu Tyr His Leu Arg Ile Ser Ala Glu Val Glu Val Val Glu 
            900                 905                 910         


Met Val Glu Asn Asp Ile Ser Ala Phe Thr Tyr Glu Arg Thr Leu Met 
        915                 920                 925             


Met Glu Gln Arg Ser Gln Met Leu Lys Gln Met Gln Leu Ser Lys Asn 
    930                 935                 940                 


Glu Gln Glu Arg Glu Ala Gln Leu Ile His Asp Arg Asn Thr Ala Ser 
945                 950                 955                 960 


His Thr Ala Ala Ala Ala Arg Thr Gln Ala Pro Pro Thr Pro Asp Lys 
                965                 970                 975     


Val Gln Met Thr Trp Thr Arg Glu Lys Leu Ile Ala Glu Lys Tyr Arg 
            980                 985                 990         


Ser Arg Asp Thr Ser Leu Ser Gly  Phe Lys Asp Leu Phe  Ser Met Lys 
        995                 1000                 1005             


Pro Asp  Gln Ser Asn Val Arg  Arg Met His Thr Ala  Val Lys Leu 
    1010                 1015                 1020             


Asn Gly  Val Val Leu Asn Lys  Ser Gln Asp Ala Gln  Leu Val Leu 
    1025                 1030                 1035             


Leu Asn  Met Pro Gly Pro Pro  Lys Asn Arg Gln Gly  Asp Glu Asn 
    1040                 1045                 1050             


Tyr Met  Glu Phe Leu Glu Val  Leu Thr Glu Gly Leu  Asn Arg Val 
    1055                 1060                 1065             


Leu Leu  Val Arg Gly Gly Gly  Arg Glu Val Ile Thr  Ile Tyr Ser 
    1070                 1075                 1080             


<210>  3526
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  3526

Met Gly Gly Glu Gln Glu Glu Glu Arg Phe Asp Gly Met Leu Leu Ala 
1               5                   10                  15      


Met Ala Gln Gln His Glu Gly Gly Val Gln Glu Leu Val Asn Thr Phe 
            20                  25                  30          


Phe Ser Phe Leu Arg Arg Lys Thr Asp Phe Phe Ile Gly Gly Glu Glu 
        35                  40                  45              


Gly Met Ala Glu Lys Leu Ile Thr Gln Thr Phe Ser His His Asn Gln 
    50                  55                  60                  


Leu Ala Gln Lys Thr Arg Arg Glu Lys Arg Ala Arg Gln Glu Ala Glu 
65                  70                  75                  80  


Arg Arg Glu Lys Ala Glu Arg Ala Ala Arg Leu Ala Lys Glu Ala Lys 
                85                  90                  95      


Ser Glu Thr Ser Gly Pro Gln Ile Lys Glu Leu Thr Asp Glu Glu Ala 
            100                 105                 110         


Glu Arg Leu Gln Leu Glu Ile Asp Gln Lys Lys Asp Ala Glu Asn His 
        115                 120                 125             


Glu Ala Gln Leu Lys Asn Gly Ser Leu Asp Ser Pro Gly Lys Gln Asp 
    130                 135                 140                 


Thr Glu Glu Asp Glu Glu Glu Asp Glu Lys Asp Lys Gly Lys Leu Lys 
145                 150                 155                 160 


Pro Asn Leu Gly Asn Gly Ala Asp Leu Pro Asn Tyr Arg Trp Thr Gln 
                165                 170                 175     


Thr Leu Ser Glu Leu Asp Leu Ala Val Pro Phe Cys Val Asn Phe Arg 
            180                 185                 190         


Leu Lys Gly Lys Asp Met Val Val Asp Ile Gln Arg Arg His Leu Arg 
        195                 200                 205             


Val Gly Leu Lys Gly Gln Pro Ala Ile Ile Asp Gly Glu Leu Tyr Asn 
    210                 215                 220                 


Glu Val Lys Val Glu Glu Ser Ser Trp Leu Ile Glu Asp Gly Lys Val 
225                 230                 235                 240 


Val Thr Val His Leu Glu Lys Ile Asn Lys Met Glu Trp Trp Ser Arg 
                245                 250                 255     


Leu Val Ser Ser Asp Pro Glu Ile Asn Thr Lys Lys Ile Asn Pro Glu 
            260                 265                 270         


Asn Ser Lys Leu Ser Asp Leu Asp Ser Glu Thr Arg Ser Met Val Glu 
        275                 280                 285             


Lys Met Met Tyr Asp Gln Arg Gln Lys Ser Met Gly Leu Pro Thr Ser 
    290                 295                 300                 


Asp Glu Gln Lys Lys Gln Glu Ile Leu Lys Lys Phe Met Asp Gln His 
305                 310                 315                 320 


Pro Glu Met Asp Phe Ser Lys Ala Lys Phe Asn 
                325                 330     


<210>  3527
<211>  762
<212>  PRT
<213>  Homo sapiens

<400>  3527

Met Ala Ser Asn Glu Arg Asp Ala Ile Ser Trp Tyr Gln Lys Lys Ile 
1               5                   10                  15      


Gly Ala Tyr Asp Gln Gln Ile Trp Glu Lys Ser Ile Glu Gln Thr Gln 
            20                  25                  30          


Ile Lys Gly Leu Lys Asn Lys Pro Lys Lys Met Gly His Ile Lys Pro 
        35                  40                  45              


Asp Leu Ile Asp Val Asp Leu Ile Arg Gly Ser Thr Phe Ala Lys Ala 
    50                  55                  60                  


Lys Pro Glu Ile Pro Trp Thr Ser Leu Thr Arg Lys Gly Leu Val Arg 
65                  70                  75                  80  


Val Val Phe Phe Pro Leu Phe Ser Asn Trp Trp Ile Gln Val Thr Ser 
                85                  90                  95      


Leu Arg Ile Phe Val Trp Leu Leu Leu Leu Tyr Phe Met Gln Val Ile 
            100                 105                 110         


Ala Ile Val Leu Tyr Leu Met Met Pro Ile Val Asn Ile Ser Glu Val 
        115                 120                 125             


Leu Gly Pro Leu Cys Leu Met Leu Leu Met Gly Thr Val His Cys Gln 
    130                 135                 140                 


Ile Val Ser Thr Gln Ile Thr Arg Pro Ser Gly Asn Asn Gly Asn Arg 
145                 150                 155                 160 


Arg Arg Arg Lys Leu Arg Lys Thr Val Asn Gly Asp Gly Ser Arg Glu 
                165                 170                 175     


Asn Gly Asn Asn Ser Ser Asp Lys Val Arg Gly Ile Glu Thr Leu Glu 
            180                 185                 190         


Ser Val Pro Ile Ile Gly Gly Phe Trp Glu Thr Ile Phe Gly Asn Arg 
        195                 200                 205             


Ile Lys Arg Val Lys Leu Ile Ser Asn Lys Gly Thr Glu Thr Asp Asn 
    210                 215                 220                 


Asp Pro Ser Cys Val His Pro Ile Ile Lys Arg Arg Gln Cys Arg Pro 
225                 230                 235                 240 


Glu Ile Arg Met Trp Gln Thr Arg Glu Lys Ala Lys Phe Ser Asp Gly 
                245                 250                 255     


Glu Lys Cys Arg Arg Glu Ala Phe Arg Arg Leu Gly Asn Gly Val Ser 
            260                 265                 270         


Asp Asp Leu Ser Ser Glu Glu Asp Gly Glu Ala Arg Thr Gln Met Ile 
        275                 280                 285             


Leu Leu Arg Arg Ser Val Glu Gly Ala Ser Ser Asp Asn Gly Cys Glu 
    290                 295                 300                 


Val Lys Asn Arg Lys Ser Ile Leu Ser Arg His Leu Asn Ser Gln Val 
305                 310                 315                 320 


Lys Lys Thr Thr Thr Arg Trp Cys His Ile Val Arg Asp Ser Asp Ser 
                325                 330                 335     


Leu Ala Glu Ser Glu Phe Glu Ser Ala Ala Phe Ser Gln Gly Ser Arg 
            340                 345                 350         


Ser Gly Val Ser Gly Gly Ser Arg Ser Leu Asn Met Ser Arg Arg Asp 
        355                 360                 365             


Ser Glu Ser Thr Arg His Asp Ser Glu Thr Glu Asp Met Leu Trp Asp 
    370                 375                 380                 


Asp Leu Leu His Gly Pro Glu Cys Arg Ser Ser Val Thr Ser Asp Ser 
385                 390                 395                 400 


Glu Gly Ala His Val Asn Thr Leu His Ser Gly Thr Lys Arg Asp Pro 
                405                 410                 415     


Lys Glu Asp Val Phe Gln Gln Asn His Leu Phe Trp Leu Gln Asn Ser 
            420                 425                 430         


Ser Pro Ser Ser Asp Arg Val Ser Ala Ile Ile Trp Glu Gly Asn Glu 
        435                 440                 445             


Cys Lys Lys Met Asp Met Ser Val Leu Glu Ile Ser Gly Ile Ile Met 
    450                 455                 460                 


Ser Arg Val Asn Ala Tyr Gln Gln Gly Val Gly Tyr Gln Met Leu Gly 
465                 470                 475                 480 


Asn Val Val Thr Ile Gly Leu Ala Phe Phe Pro Phe Leu His Arg Leu 
                485                 490                 495     


Phe Arg Glu Lys Ser Leu Asp Gln Leu Lys Ser Ile Ser Ala Glu Glu 
            500                 505                 510         


Ile Leu Thr Leu Phe Cys Gly Ala Pro Pro Val Thr Pro Ile Ile Val 
        515                 520                 525             


Leu Ser Ile Ile Asn Phe Phe Glu Arg Leu Cys Leu Thr Trp Met Phe 
    530                 535                 540                 


Phe Phe Met Met Cys Val Ala Glu Arg Thr Tyr Lys Gln Arg Phe Leu 
545                 550                 555                 560 


Phe Ala Lys Leu Phe Ser His Ile Thr Ser Ala Arg Lys Ala Arg Lys 
                565                 570                 575     


Tyr Glu Ile Pro His Phe Arg Leu Lys Lys Val Glu Asn Ile Lys Ile 
            580                 585                 590         


Trp Leu Ser Leu Arg Ser Tyr Leu Lys Arg Arg Gly Pro Gln Arg Ser 
        595                 600                 605             


Val Asp Val Val Val Ser Ser Val Phe Leu Leu Thr Leu Ser Ile Ala 
    610                 615                 620                 


Phe Ile Cys Cys Ala Gln Val Leu Gln Gly His Lys Thr Phe Leu Asn 
625                 630                 635                 640 


Asp Ala Tyr Asn Trp Glu Phe Leu Ile Trp Glu Thr Ala Leu Leu Leu 
                645                 650                 655     


Phe Leu Leu Arg Leu Ala Ser Leu Gly Ser Glu Thr Asn Lys Lys Tyr 
            660                 665                 670         


Ser Asn Val Ser Ile Leu Leu Thr Glu Gln Ile Asn Leu Tyr Leu Lys 
        675                 680                 685             


Met Glu Lys Lys Pro Asn Lys Lys Glu Gln Leu Thr Leu Val Asn Asn 
    690                 695                 700                 


Val Leu Lys Leu Ser Thr Lys Leu Leu Lys Glu Leu Asp Thr Pro Phe 
705                 710                 715                 720 


Arg Leu Tyr Gly Leu Thr Met Asn Pro Leu Ile Tyr Asn Ile Thr Arg 
                725                 730                 735     


Val Val Ile Leu Ser Ala Val Ser Gly Val Ile Ser Asp Leu Leu Gly 
            740                 745                 750         


Phe Asn Ile Arg Leu Trp Lys Ile Lys Ser 
        755                 760         


<210>  3528
<211>  1224
<212>  PRT
<213>  Homo sapiens

<400>  3528

Met Glu Pro Leu Leu Leu Gly Arg Gly Leu Ile Val Tyr Leu Met Phe 
1               5                   10                  15      


Leu Leu Leu Lys Phe Ser Lys Ala Ile Glu Ile Pro Ser Ser Val Gln 
            20                  25                  30          


Gln Val Pro Thr Ile Ile Lys Gln Ser Lys Val Gln Val Ala Phe Pro 
        35                  40                  45              


Phe Asp Glu Tyr Phe Gln Ile Glu Cys Glu Ala Lys Gly Asn Pro Glu 
    50                  55                  60                  


Pro Thr Phe Ser Trp Thr Lys Asp Gly Asn Pro Phe Tyr Phe Thr Asp 
65                  70                  75                  80  


His Arg Ile Ile Pro Ser Asn Asn Ser Gly Thr Phe Arg Ile Pro Asn 
                85                  90                  95      


Glu Gly His Ile Ser His Phe Gln Gly Lys Tyr Arg Cys Phe Ala Ser 
            100                 105                 110         


Asn Lys Leu Gly Ile Ala Met Ser Glu Glu Ile Glu Phe Ile Val Pro 
        115                 120                 125             


Ser Val Pro Lys Phe Pro Lys Glu Lys Ile Asp Pro Leu Glu Val Glu 
    130                 135                 140                 


Glu Gly Asp Pro Ile Val Leu Pro Cys Asn Pro Pro Lys Gly Leu Pro 
145                 150                 155                 160 


Pro Leu His Ile Tyr Trp Met Asn Ile Glu Leu Glu His Ile Glu Gln 
                165                 170                 175     


Asp Glu Arg Val Tyr Met Ser Gln Lys Gly Asp Leu Tyr Phe Ala Asn 
            180                 185                 190         


Val Glu Glu Lys Asp Ser Arg Asn Asp Tyr Cys Cys Phe Ala Ala Phe 
        195                 200                 205             


Pro Arg Leu Arg Thr Ile Val Gln Lys Met Pro Met Lys Leu Thr Val 
    210                 215                 220                 


Asn Ser Leu Lys His Ala Asn Asp Ser Ser Ser Ser Thr Glu Ile Gly 
225                 230                 235                 240 


Ser Lys Ala Asn Ser Ile Lys Gln Arg Lys Pro Lys Leu Leu Leu Pro 
                245                 250                 255     


Pro Thr Glu Ser Gly Ser Glu Ser Ser Ile Thr Ile Leu Lys Gly Glu 
            260                 265                 270         


Ile Leu Leu Leu Glu Cys Phe Ala Glu Gly Leu Pro Thr Pro Gln Val 
        275                 280                 285             


Asp Trp Asn Lys Ile Gly Gly Asp Leu Pro Lys Gly Arg Glu Thr Lys 
    290                 295                 300                 


Glu Asn Tyr Gly Lys Thr Leu Lys Ile Glu Asn Val Ser Tyr Gln Asp 
305                 310                 315                 320 


Lys Gly Asn Tyr Arg Cys Thr Ala Ser Asn Phe Leu Gly Thr Ala Thr 
                325                 330                 335     


His Asp Phe His Val Ile Val Glu Glu Pro Pro Arg Trp Thr Lys Lys 
            340                 345                 350         


Pro Gln Ser Ala Val Tyr Ser Thr Gly Ser Asn Gly Ile Leu Leu Cys 
        355                 360                 365             


Glu Ala Glu Gly Glu Pro Gln Pro Thr Ile Lys Trp Arg Val Asn Gly 
    370                 375                 380                 


Ser Pro Val Asp Asn His Pro Phe Ala Gly Asp Val Val Phe Pro Arg 
385                 390                 395                 400 


Glu Ile Ser Phe Thr Asn Leu Gln Pro Asn His Thr Ala Val Tyr Gln 
                405                 410                 415     


Cys Glu Ala Ser Asn Val His Gly Thr Ile Leu Ala Asn Ala Asn Ile 
            420                 425                 430         


Asp Val Val Asp Val Arg Pro Leu Ile Gln Thr Lys Asp Gly Glu Asn 
        435                 440                 445             


Tyr Ala Thr Val Val Gly Tyr Ser Ala Phe Leu His Cys Glu Phe Phe 
    450                 455                 460                 


Ala Ser Pro Glu Ala Val Val Ser Trp Gln Lys Val Glu Glu Val Lys 
465                 470                 475                 480 


Pro Leu Glu Gly Arg Arg Tyr His Ile Tyr Glu Asn Gly Thr Leu Gln 
                485                 490                 495     


Ile Asn Arg Thr Thr Glu Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val 
            500                 505                 510         


Glu Asn Ala Ile Gly Lys Thr Ala Val Thr Ala Asn Leu Asp Ile Arg 
        515                 520                 525             


Asn Ala Thr Lys Leu Arg Val Ser Pro Lys Asn Pro Arg Ile Pro Lys 
    530                 535                 540                 


Leu His Met Leu Glu Leu His Cys Glu Ser Lys Cys Asp Ser His Leu 
545                 550                 555                 560 


Lys His Ser Leu Lys Leu Ser Trp Ser Lys Asp Gly Glu Ala Phe Glu 
                565                 570                 575     


Ile Asn Gly Thr Glu Asp Gly Arg Ile Ile Ile Asp Gly Ala Asn Leu 
            580                 585                 590         


Thr Ile Ser Asn Val Thr Leu Glu Asp Gln Gly Ile Tyr Cys Cys Ser 
        595                 600                 605             


Ala His Thr Ala Leu Asp Ser Ala Ala Asp Ile Thr Gln Val Thr Val 
    610                 615                 620                 


Leu Asp Val Pro Asp Pro Pro Glu Asn Leu His Leu Ser Glu Arg Gln 
625                 630                 635                 640 


Asn Arg Ser Val Arg Leu Thr Trp Glu Ala Gly Ala Asp His Asn Ser 
                645                 650                 655     


Asn Ile Ser Glu Tyr Ile Val Glu Phe Glu Gly Asn Lys Glu Glu Pro 
            660                 665                 670         


Gly Arg Trp Glu Glu Leu Thr Arg Val Gln Gly Lys Lys Thr Thr Val 
        675                 680                 685             


Ile Leu Pro Leu Ala Pro Phe Val Arg Tyr Gln Phe Arg Val Ile Ala 
    690                 695                 700                 


Val Asn Glu Val Gly Arg Ser Gln Pro Ser Gln Pro Ser Asp His His 
705                 710                 715                 720 


Glu Thr Pro Pro Ala Ala Pro Asp Arg Asn Pro Gln Asn Ile Arg Val 
                725                 730                 735     


Gln Ala Ser Gln Pro Lys Glu Met Ile Ile Lys Trp Glu Pro Leu Lys 
            740                 745                 750         


Ser Met Glu Gln Asn Gly Pro Gly Leu Glu Tyr Arg Val Thr Trp Lys 
        755                 760                 765             


Pro Gln Gly Ala Pro Val Glu Trp Glu Glu Glu Thr Val Thr Asn His 
    770                 775                 780                 


Thr Leu Arg Val Met Thr Pro Ala Val Tyr Ala Pro Tyr Asp Val Lys 
785                 790                 795                 800 


Val Gln Ala Ile Asn Gln Leu Gly Ser Gly Pro Asp Pro Gln Ser Val 
                805                 810                 815     


Thr Leu Tyr Ser Gly Glu Asp Tyr Pro Asp Thr Ala Pro Val Ile His 
            820                 825                 830         


Gly Val Asp Val Ile Asn Ser Thr Leu Val Lys Val Thr Trp Ser Thr 
        835                 840                 845             


Val Pro Lys Asp Arg Val His Gly Arg Leu Lys Gly Tyr Gln Ile Asn 
    850                 855                 860                 


Trp Trp Lys Thr Lys Ser Leu Leu Asp Gly Arg Thr His Pro Lys Glu 
865                 870                 875                 880 


Val Asn Ile Leu Arg Phe Ser Gly Gln Arg Asn Ser Gly Met Val Pro 
                885                 890                 895     


Ser Leu Asp Ala Phe Ser Glu Phe His Leu Thr Val Leu Ala Tyr Asn 
            900                 905                 910         


Ser Lys Gly Ala Gly Pro Glu Ser Glu Pro Tyr Ile Phe Gln Thr Pro 
        915                 920                 925             


Glu Gly Val Pro Glu Gln Pro Thr Phe Leu Lys Val Ile Lys Val Asp 
    930                 935                 940                 


Lys Asp Thr Ala Thr Leu Ser Trp Gly Leu Pro Lys Lys Leu Asn Gly 
945                 950                 955                 960 


Asn Leu Thr Gly Tyr Leu Leu Gln Tyr Gln Ile Ile Asn Asp Thr Tyr 
                965                 970                 975     


Glu Ile Gly Glu Leu Asn Asp Ile Asn Ile Thr Thr Pro Ser Lys Pro 
            980                 985                 990         


Ser Trp His Leu Ser Asn Leu Asn  Ala Thr Thr Lys Tyr  Lys Phe Tyr 
        995                 1000                 1005             


Leu Arg  Ala Cys Thr Ser Gln  Gly Cys Gly Lys Pro  Ile Thr Glu 
    1010                 1015                 1020             


Glu Ser  Ser Thr Leu Gly Glu  Gly Ser Lys Gly Ile  Gly Lys Ile 
    1025                 1030                 1035             


Ser Gly  Val Asn Leu Thr Gln  Lys Thr His Pro Ile  Glu Val Phe 
    1040                 1045                 1050             


Glu Pro  Gly Ala Glu His Ile  Val Arg Leu Met Thr  Lys Asn Trp 
    1055                 1060                 1065             


Gly Asp  Asn Asp Ser Ile Phe  Gln Asp Val Ile Glu  Thr Arg Gly 
    1070                 1075                 1080             


Arg Glu  Tyr Ala Gly Leu Tyr  Asp Asp Ile Ser Thr  Gln Gly Trp 
    1085                 1090                 1095             


Phe Ile  Gly Leu Met Cys Ala  Ile Ala Leu Leu Thr  Leu Leu Leu 
    1100                 1105                 1110             


Leu Thr  Val Cys Phe Val Lys  Arg Asn Arg Gly Gly  Lys Tyr Ser 
    1115                 1120                 1125             


Val Lys  Glu Lys Glu Asp Leu  His Pro Asp Pro Glu  Ile Gln Ser 
    1130                 1135                 1140             


Val Lys  Asp Glu Thr Phe Gly  Glu Tyr Ser Asp Ser  Asp Glu Lys 
    1145                 1150                 1155             


Pro Leu  Lys Gly Ser Leu Arg  Ser Leu Asn Arg Asp  Met Gln Pro 
    1160                 1165                 1170             


Thr Glu  Ser Ala Asp Ser Leu  Val Glu Tyr Gly Glu  Gly Asp His 
    1175                 1180                 1185             


Gly Leu  Phe Ser Glu Asp Gly  Ser Phe Ile Gly Ala  Tyr Ala Gly 
    1190                 1195                 1200             


Ser Lys  Glu Lys Gly Ser Val  Glu Ser Asn Gly Ser  Ser Thr Ala 
    1205                 1210                 1215             


Thr Phe  Pro Leu Arg Ala 
    1220                 


<210>  3529
<211>  684
<212>  PRT
<213>  Homo sapiens

<400>  3529

Met Ala Arg His Arg Asn Val Arg Gly Tyr Asn Tyr Asp Glu Asp Phe 
1               5                   10                  15      


Glu Asp Asp Asp Leu Tyr Gly Gln Ser Val Glu Asp Asp Tyr Cys Ile 
            20                  25                  30          


Ser Pro Ser Thr Ala Ala Gln Phe Ile Tyr Ser Arg Arg Asp Lys Pro 
        35                  40                  45              


Ser Val Glu Pro Val Glu Glu Tyr Asp Tyr Glu Asp Leu Lys Glu Ser 
    50                  55                  60                  


Ser Asn Ser Val Ser Asn His Gln Leu Ser Gly Phe Asp Gln Ala Arg 
65                  70                  75                  80  


Leu Tyr Ser Cys Leu Asp His Met Arg Glu Val Leu Gly Asp Ala Val 
                85                  90                  95      


Pro Asp Glu Ile Leu Ile Glu Ala Val Leu Lys Asn Lys Phe Asp Val 
            100                 105                 110         


Gln Lys Ala Leu Ser Gly Val Leu Glu Gln Asp Arg Val Gln Ser Leu 
        115                 120                 125             


Lys Asp Lys Asn Glu Ala Thr Val Ser Thr Gly Lys Ile Ala Lys Gly 
    130                 135                 140                 


Lys Pro Val Asp Ser Gln Thr Ser Arg Ser Glu Ser Glu Ile Val Pro 
145                 150                 155                 160 


Lys Val Ala Lys Met Thr Val Ser Gly Lys Lys Gln Thr Met Gly Phe 
                165                 170                 175     


Glu Val Pro Gly Val Ser Ser Glu Glu Asn Gly His Ser Phe His Thr 
            180                 185                 190         


Pro Gln Lys Gly Pro Pro Ile Glu Asp Ala Ile Ala Ser Ser Asp Val 
        195                 200                 205             


Leu Glu Thr Ala Ser Lys Ser Ala Asn Pro Pro His Thr Ile Gln Ala 
    210                 215                 220                 


Ser Glu Glu Gln Ser Ser Thr Pro Ala Pro Val Lys Lys Ser Gly Lys 
225                 230                 235                 240 


Leu Arg Gln Gln Ile Asp Val Lys Ala Glu Leu Glu Lys Arg Gln Gly 
                245                 250                 255     


Gly Lys Gln Leu Leu Asn Leu Val Val Ile Gly His Val Asp Ala Gly 
            260                 265                 270         


Lys Ser Thr Leu Met Gly His Met Leu Tyr Leu Leu Gly Asn Ile Asn 
        275                 280                 285             


Lys Arg Thr Met His Lys Tyr Glu Gln Glu Ser Lys Lys Ala Gly Lys 
    290                 295                 300                 


Ala Ser Phe Ala Tyr Ala Trp Val Leu Asp Glu Thr Gly Glu Glu Arg 
305                 310                 315                 320 


Glu Arg Gly Val Thr Met Asp Val Gly Met Thr Lys Phe Glu Thr Thr 
                325                 330                 335     


Thr Lys Val Ile Thr Leu Met Asp Ala Pro Gly His Lys Asp Phe Ile 
            340                 345                 350         


Pro Asn Met Ile Thr Gly Ala Ala Gln Ala Asp Val Ala Val Leu Val 
        355                 360                 365             


Val Asp Ala Ser Arg Gly Glu Phe Glu Ala Gly Phe Glu Thr Gly Gly 
    370                 375                 380                 


Gln Thr Arg Glu His Gly Leu Leu Val Arg Ser Leu Gly Val Thr Gln 
385                 390                 395                 400 


Leu Ala Val Ala Val Asn Lys Met Asp Gln Val Asn Trp Gln Gln Glu 
                405                 410                 415     


Arg Phe Gln Glu Ile Thr Gly Lys Leu Gly His Phe Leu Lys Gln Ala 
            420                 425                 430         


Gly Phe Lys Glu Ser Asp Val Gly Phe Ile Pro Thr Ser Gly Leu Ser 
        435                 440                 445             


Gly Glu Asn Leu Ile Thr Arg Ser Gln Ser Ser Glu Leu Thr Lys Trp 
    450                 455                 460                 


Tyr Lys Gly Leu Cys Leu Leu Glu Gln Ile Asp Ser Phe Lys Pro Pro 
465                 470                 475                 480 


Gln Arg Ser Ile Asp Lys Pro Phe Arg Leu Cys Val Ser Asp Val Phe 
                485                 490                 495     


Lys Asp Gln Gly Ser Gly Phe Cys Ile Thr Gly Lys Ile Glu Ala Gly 
            500                 505                 510         


Tyr Ile Gln Thr Gly Asp Arg Leu Leu Ala Met Pro Pro Asn Glu Thr 
        515                 520                 525             


Cys Thr Val Lys Gly Ile Thr Leu His Asp Glu Pro Val Asp Trp Ala 
    530                 535                 540                 


Ala Ala Gly Asp His Val Ser Leu Thr Leu Val Gly Met Asp Ile Ile 
545                 550                 555                 560 


Lys Ile Asn Val Gly Cys Ile Phe Cys Gly Pro Lys Val Pro Ile Lys 
                565                 570                 575     


Ala Cys Thr Arg Phe Arg Ala Arg Ile Leu Ile Phe Asn Ile Glu Ile 
            580                 585                 590         


Pro Ile Thr Lys Gly Phe Pro Val Leu Leu His Tyr Gln Thr Val Ser 
        595                 600                 605             


Glu Pro Ala Val Ile Lys Arg Leu Ile Ser Val Leu Asn Lys Ser Thr 
    610                 615                 620                 


Gly Glu Val Thr Lys Lys Lys Pro Lys Phe Leu Thr Lys Gly Gln Asn 
625                 630                 635                 640 


Ala Leu Val Glu Leu Gln Thr Gln Arg Pro Ile Ala Leu Glu Leu Tyr 
                645                 650                 655     


Lys Asp Phe Lys Glu Leu Gly Arg Phe Met Leu Arg Tyr Gly Gly Ser 
            660                 665                 670         


Thr Ile Ala Ala Gly Val Val Thr Glu Ile Lys Glu 
        675                 680                 


<210>  3530
<211>  602
<212>  PRT
<213>  Homo sapiens

<400>  3530

Met Ala Arg Leu Thr Lys Arg Arg Gln Ala Asp Thr Lys Ala Ile Gln 
1               5                   10                  15      


His Leu Trp Ala Ala Ile Glu Ile Ile Arg Asn Gln Lys Gln Ile Ala 
            20                  25                  30          


Asn Ile Asp Arg Ile Thr Lys Tyr Met Ser Arg Val His Gly Met His 
        35                  40                  45              


Pro Lys Glu Thr Thr Arg Gln Leu Ser Leu Ala Val Lys Asp Gly Leu 
    50                  55                  60                  


Ile Val Glu Thr Leu Thr Val Gly Cys Lys Gly Ser Lys Ala Gly Ile 
65                  70                  75                  80  


Glu Gln Glu Gly Tyr Trp Leu Pro Gly Asp Glu Ile Asp Trp Glu Thr 
                85                  90                  95      


Glu Asn His Asp Trp Tyr Cys Phe Glu Cys His Leu Pro Gly Glu Val 
            100                 105                 110         


Leu Ile Cys Asp Leu Cys Phe Arg Val Tyr His Ser Lys Cys Leu Ser 
        115                 120                 125             


Asp Glu Phe Arg Leu Arg Asp Ser Ser Ser Pro Trp Gln Cys Pro Val 
    130                 135                 140                 


Cys Arg Ser Ile Lys Lys Lys Asn Thr Asn Lys Gln Glu Met Gly Thr 
145                 150                 155                 160 


Tyr Leu Arg Phe Ile Val Ser Arg Met Lys Glu Arg Ala Ile Asp Leu 
                165                 170                 175     


Asn Lys Lys Gly Lys Asp Asn Lys His Pro Met Tyr Arg Arg Leu Val 
            180                 185                 190         


His Ser Ala Val Asp Val Pro Thr Ile Gln Glu Lys Val Asn Glu Gly 
        195                 200                 205             


Lys Tyr Arg Ser Tyr Glu Glu Phe Lys Ala Asp Ala Gln Leu Leu Leu 
    210                 215                 220                 


His Asn Thr Val Ile Phe Tyr Gly Ala Asp Ser Glu Gln Ala Asp Ile 
225                 230                 235                 240 


Ala Arg Met Leu Tyr Lys Asp Thr Cys His Glu Leu Asp Glu Leu Gln 
                245                 250                 255     


Leu Cys Lys Asn Cys Phe Tyr Leu Ser Asn Ala Arg Pro Asp Asn Trp 
            260                 265                 270         


Phe Cys Tyr Pro Cys Ile Pro Asn His Glu Leu Val Trp Ala Lys Met 
        275                 280                 285             


Lys Gly Phe Gly Phe Trp Pro Ala Lys Val Met Gln Lys Glu Asp Asn 
    290                 295                 300                 


Gln Val Asp Val Arg Phe Phe Gly His His His Gln Arg Ala Trp Ile 
305                 310                 315                 320 


Pro Ser Glu Asn Ile Gln Asp Ile Thr Val Asn Ile His Arg Leu His 
                325                 330                 335     


Val Lys Arg Ser Met Gly Trp Lys Lys Ala Cys Asp Glu Leu Glu Leu 
            340                 345                 350         


His Gln Arg Phe Leu Arg Glu Gly Arg Phe Trp Lys Ser Lys Asn Glu 
        355                 360                 365             


Asp Arg Gly Glu Glu Glu Ala Glu Ser Ser Ile Ser Ser Thr Ser Asn 
    370                 375                 380                 


Glu Gln Leu Lys Val Thr Gln Glu Pro Arg Ala Lys Lys Gly Arg Arg 
385                 390                 395                 400 


Asn Gln Ser Val Glu Pro Lys Lys Glu Glu Pro Glu Pro Glu Thr Glu 
                405                 410                 415     


Ala Val Ser Ser Ser Gln Glu Ile Pro Thr Met Pro Gln Pro Ile Glu 
            420                 425                 430         


Lys Val Ser Val Ser Thr Gln Thr Lys Lys Leu Ser Ala Ser Ser Pro 
        435                 440                 445             


Arg Met Leu His Arg Ser Thr Gln Thr Thr Asn Asp Gly Val Cys Gln 
    450                 455                 460                 


Ser Met Cys His Asp Lys Tyr Thr Lys Ile Phe Asn Asp Phe Lys Asp 
465                 470                 475                 480 


Arg Met Lys Ser Asp His Lys Arg Glu Thr Glu Arg Val Val Arg Glu 
                485                 490                 495     


Ala Leu Glu Lys Leu Arg Ser Glu Met Glu Glu Glu Lys Arg Gln Ala 
            500                 505                 510         


Val Asn Lys Ala Val Ala Asn Met Gln Gly Glu Met Asp Arg Lys Cys 
        515                 520                 525             


Lys Gln Val Lys Glu Lys Cys Lys Glu Glu Phe Val Glu Glu Ile Lys 
    530                 535                 540                 


Lys Leu Ala Thr Gln His Lys Gln Leu Ile Ser Gln Thr Lys Lys Lys 
545                 550                 555                 560 


Gln Trp Cys Tyr Asn Cys Glu Glu Glu Ala Met Tyr His Cys Cys Trp 
                565                 570                 575     


Asn Thr Ser Tyr Cys Ser Ile Lys Cys Gln Gln Glu His Trp His Ala 
            580                 585                 590         


Glu His Lys Arg Thr Cys Arg Arg Lys Arg 
        595                 600         


<210>  3531
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  3531

Met Ala Thr Lys Thr Glu Leu Ser Pro Thr Ala Arg Glu Ser Lys Asn 
1               5                   10                  15      


Ala Gln Asp Met Gln Val Asp Glu Thr Leu Ile Pro Arg Lys Val Pro 
            20                  25                  30          


Ser Leu Cys Ser Ala Arg Tyr Gly Ile Ala Leu Val Leu His Phe Cys 
        35                  40                  45              


Asn Phe Thr Thr Ile Ala Gln Asn Val Ile Met Asn Ile Thr Met Val 
    50                  55                  60                  


Ala Met Val Asn Ser Thr Ser Pro Gln Ser Gln Leu Asn Asp Ser Ser 
65                  70                  75                  80  


Glu Val Leu Pro Val Asp Ser Phe Gly Gly Leu Ser Lys Ala Pro Lys 
                85                  90                  95      


Ser Leu Pro Ala Lys Ser Ser Ile Leu Gly Gly Gln Phe Ala Ile Trp 
            100                 105                 110         


Glu Lys Trp Gly Pro Pro Gln Glu Arg Ser Arg Leu Cys Ser Ile Ala 
        115                 120                 125             


Leu Ser Gly Met Leu Leu Gly Cys Phe Thr Ala Ile Leu Ile Gly Gly 
    130                 135                 140                 


Phe Ile Ser Glu Thr Leu Gly Trp Pro Phe Val Phe Tyr Ile Phe Gly 
145                 150                 155                 160 


Gly Val Gly Cys Val Cys Cys Leu Leu Trp Phe Val Val Ile Tyr Asp 
                165                 170                 175     


Asp Pro Val Ser Tyr Pro Trp Ile Ser Thr Ser Glu Lys Glu Tyr Ile 
            180                 185                 190         


Ile Ser Ser Leu Lys Gln Gln Val Gly Ser Ser Lys Gln Pro Leu Pro 
        195                 200                 205             


Ile Lys Ala Met Leu Arg Ser Leu Pro Ile Trp Ser Ile Cys Leu Gly 
    210                 215                 220                 


Cys Phe Ser His Gln Trp Leu Val Ser Thr Met Val Val Tyr Ile Pro 
225                 230                 235                 240 


Thr Tyr Ile Ser Ser Val Tyr His Val Asn Ile Arg Asp Asn Gly Leu 
                245                 250                 255     


Leu Ser Ala Leu Pro Phe Ile Val Ala Trp Val Ile Gly Met Val Gly 
            260                 265                 270         


Gly Tyr Leu Ala Asp Phe Leu Leu Thr Lys Lys Phe Arg Leu Ile Thr 
        275                 280                 285             


Val Arg Lys Ile Ala Thr Ile Leu Gly Ser Leu Pro Ser Ser Ala Leu 
    290                 295                 300                 


Ile Val Ser Leu Pro Tyr Leu Asn Ser Gly Tyr Ile Thr Ala Thr Ala 
305                 310                 315                 320 


Leu Leu Thr Leu Ser Cys Gly Leu Ser Thr Leu Cys Gln Ser Gly Ile 
                325                 330                 335     


Tyr Ile Asn Val Leu Asp Ile Ala Pro Arg Tyr Ser Ser Phe Leu Met 
            340                 345                 350         


Gly Ala Ser Arg Gly Phe Ser Ser Ile Ala Pro Val Ile Val Pro Thr 
        355                 360                 365             


Val Ser Gly Phe Leu Leu Ser Gln Asp Pro Glu Phe Gly Trp Arg Asn 
    370                 375                 380                 


Val Phe Phe Leu Leu Phe Ala Val Asn Leu Leu Gly Leu Leu Phe Tyr 
385                 390                 395                 400 


Leu Ile Phe Gly Glu Ala Asp Val Gln Glu Trp Ala Lys Glu Arg Lys 
                405                 410                 415     


Leu Thr Arg Leu 
            420 


<210>  3532
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  3532

Met Ala Gly Ile Glu Leu Glu Arg Cys Gln Gln Gln Ala Asn Glu Val 
1               5                   10                  15      


Thr Glu Ile Met Arg Asn Asn Phe Gly Lys Val Leu Glu Arg Gly Val 
            20                  25                  30          


Lys Leu Ala Glu Leu Gln Gln Arg Ser Asp Gln Leu Leu Asp Met Ser 
        35                  40                  45              


Ser Thr Phe Asn Lys Thr Thr Gln Asn Leu Ala Gln Lys Lys Cys Trp 
    50                  55                  60                  


Glu Asn Ile Arg Tyr Arg Ile Cys Val Gly Leu Val Val Val Gly Val 
65                  70                  75                  80  


Leu Leu Ile Ile Leu Ile Val Leu Leu Val Val Phe Leu Pro Gln Ser 
                85                  90                  95      


Ser Asp Ser Ser Ser Ala Pro Arg Thr Gln Asp Ala Gly Ile Ala Ser 
            100                 105                 110         


Gly Pro Gly Asn 
        115     


<210>  3533
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  3533

Met Glu Phe Thr Asp Arg Asn Tyr Thr Leu Val Thr Glu Phe Ile Leu 
1               5                   10                  15      


Leu Gly Phe Pro Thr Arg Pro Glu Leu Gln Ile Val Leu Phe Leu Met 
            20                  25                  30          


Phe Leu Thr Leu Tyr Ala Ile Ile Leu Ile Gly Asn Ile Gly Leu Met 
        35                  40                  45              


Leu Leu Ile Arg Ile Asp Pro His Leu Gln Thr Pro Met Tyr Phe Phe 
    50                  55                  60                  


Leu Ser Asn Leu Ser Phe Val Asp Leu Cys Tyr Phe Ser Asp Ile Val 
65                  70                  75                  80  


Pro Lys Met Leu Val Asn Phe Leu Ser Glu Asn Lys Ser Ile Ser Tyr 
                85                  90                  95      


Tyr Gly Cys Ala Leu Gln Phe Tyr Phe Phe Cys Thr Phe Ala Asp Thr 
            100                 105                 110         


Glu Ser Phe Ile Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile 
        115                 120                 125             


Cys Asn Pro Leu Leu Tyr Thr Val Val Met Ser Arg Gly Ile Cys Met 
    130                 135                 140                 


Arg Leu Ile Val Leu Ser Tyr Leu Gly Gly Asn Met Ser Ser Leu Val 
145                 150                 155                 160 


His Thr Ser Phe Ala Phe Ile Leu Lys Tyr Cys Asp Lys Asn Val Ile 
                165                 170                 175     


Asn His Phe Phe Cys Asp Leu Pro Pro Leu Leu Lys Leu Ser Cys Thr 
            180                 185                 190         


Asp Thr Thr Ile Asn Glu Trp Leu Leu Ser Thr Tyr Gly Ser Ser Val 
        195                 200                 205             


Glu Ile Ile Cys Phe Ile Ile Ile Ile Ile Ser Tyr Phe Phe Ile Leu 
    210                 215                 220                 


Leu Ser Val Leu Lys Ile Arg Ser Phe Ser Gly Arg Lys Lys Thr Phe 
225                 230                 235                 240 


Ser Thr Cys Ala Ser His Leu Thr Ser Val Thr Ile Tyr Gln Gly Thr 
                245                 250                 255     


Leu Leu Phe Ile Tyr Ser Arg Pro Ser Tyr Leu Tyr Ser Pro Asn Thr 
            260                 265                 270         


Asp Lys Ile Ile Ser Val Phe Tyr Thr Ile Phe Ile Pro Val Leu Asn 
        275                 280                 285             


Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Ala Ala Glu 
    290                 295                 300                 


Lys Val Leu Arg Ser Lys Val Asp Ser Ser 
305                 310                 


<210>  3534
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  3534

Met Asp Glu Thr Gly Asn Leu Thr Val Ser Ser Ala Thr Cys His Asp 
1               5                   10                  15      


Thr Ile Asp Asp Phe Arg Asn Gln Val Tyr Ser Thr Leu Tyr Ser Met 
            20                  25                  30          


Ile Ser Val Val Gly Phe Phe Gly Asn Gly Phe Val Leu Tyr Val Leu 
        35                  40                  45              


Ile Lys Thr Tyr His Lys Lys Ser Ala Phe Gln Val Tyr Met Ile Asn 
    50                  55                  60                  


Leu Ala Val Ala Asp Leu Leu Cys Val Cys Thr Leu Pro Leu Arg Val 
65                  70                  75                  80  


Val Tyr Tyr Val His Lys Gly Ile Trp Leu Phe Gly Asp Phe Leu Cys 
                85                  90                  95      


Arg Leu Ser Thr Tyr Ala Leu Tyr Val Asn Leu Tyr Cys Ser Ile Phe 
            100                 105                 110         


Phe Met Thr Ala Met Ser Phe Phe Arg Cys Ile Ala Ile Val Phe Pro 
        115                 120                 125             


Val Gln Asn Ile Asn Leu Val Thr Gln Lys Lys Ala Arg Phe Val Cys 
    130                 135                 140                 


Val Gly Ile Trp Ile Phe Val Ile Leu Thr Ser Ser Pro Phe Leu Met 
145                 150                 155                 160 


Ala Lys Pro Gln Lys Asp Glu Lys Asn Asn Thr Lys Cys Phe Glu Pro 
                165                 170                 175     


Pro Gln Asp Asn Gln Thr Lys Asn His Val Leu Val Leu His Tyr Val 
            180                 185                 190         


Ser Leu Phe Val Gly Phe Ile Ile Pro Phe Val Ile Ile Ile Val Cys 
        195                 200                 205             


Tyr Thr Met Ile Ile Leu Thr Leu Leu Lys Lys Ser Met Lys Lys Asn 
    210                 215                 220                 


Leu Ser Ser His Lys Lys Ala Ile Gly Met Ile Met Val Val Thr Ala 
225                 230                 235                 240 


Ala Phe Leu Val Ser Phe Met Pro Tyr His Ile Gln Arg Thr Ile His 
                245                 250                 255     


Leu His Phe Leu His Asn Glu Thr Lys Pro Cys Asp Ser Val Leu Arg 
            260                 265                 270         


Met Gln Lys Ser Val Val Ile Thr Leu Ser Leu Ala Ala Ser Asn Cys 
        275                 280                 285             


Cys Phe Asp Pro Leu Leu Tyr Phe Phe Ser Gly Gly Asn Phe Arg Lys 
    290                 295                 300                 


Arg Leu Ser Thr Phe Arg Lys His Ser Leu Ser Ser Val Thr Tyr Val 
305                 310                 315                 320 


Pro Arg Lys Lys Ala Ser Leu Pro Glu Lys Gly Glu Glu Ile Cys Lys 
                325                 330                 335     


Val 
    


<210>  3535
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  3535

Met Ala Asp Asp Tyr Gly Ser Glu Ser Thr Ser Ser Met Glu Asp Tyr 
1               5                   10                  15      


Val Asn Phe Asn Phe Thr Asp Phe Tyr Cys Glu Lys Asn Asn Val Arg 
            20                  25                  30          


Gln Phe Ala Ser His Phe Leu Pro Pro Leu Tyr Trp Leu Val Phe Ile 
        35                  40                  45              


Val Gly Ala Leu Gly Asn Ser Leu Val Ile Leu Val Tyr Trp Tyr Cys 
    50                  55                  60                  


Thr Arg Val Lys Thr Met Thr Asp Met Phe Leu Leu Asn Leu Ala Ile 
65                  70                  75                  80  


Ala Asp Leu Leu Phe Leu Val Thr Leu Pro Phe Trp Ala Ile Ala Ala 
                85                  90                  95      


Ala Asp Gln Trp Lys Phe Gln Thr Phe Met Cys Lys Val Val Asn Ser 
            100                 105                 110         


Met Tyr Lys Met Asn Phe Tyr Ser Cys Val Leu Leu Ile Met Cys Ile 
        115                 120                 125             


Ser Val Asp Arg Tyr Ile Ala Ile Ala Gln Ala Met Arg Ala His Thr 
    130                 135                 140                 


Trp Arg Glu Lys Arg Leu Leu Tyr Ser Lys Met Val Cys Phe Thr Ile 
145                 150                 155                 160 


Trp Val Leu Ala Ala Ala Leu Cys Ile Pro Glu Ile Leu Tyr Ser Gln 
                165                 170                 175     


Ile Lys Glu Glu Ser Gly Ile Ala Ile Cys Thr Met Val Tyr Pro Ser 
            180                 185                 190         


Asp Glu Ser Thr Lys Leu Lys Ser Ala Val Leu Thr Leu Lys Val Ile 
        195                 200                 205             


Leu Gly Phe Phe Leu Pro Phe Val Val Met Ala Cys Cys Tyr Thr Ile 
    210                 215                 220                 


Ile Ile His Thr Leu Ile Gln Ala Lys Lys Ser Ser Lys His Lys Ala 
225                 230                 235                 240 


Leu Lys Val Thr Ile Thr Val Leu Thr Val Phe Val Leu Ser Gln Phe 
                245                 250                 255     


Pro Tyr Asn Cys Ile Leu Leu Val Gln Thr Ile Asp Ala Tyr Ala Met 
            260                 265                 270         


Phe Ile Ser Asn Cys Ala Val Ser Thr Asn Ile Asp Ile Cys Phe Gln 
        275                 280                 285             


Val Thr Gln Thr Ile Ala Phe Phe His Ser Cys Leu Asn Pro Val Leu 
    290                 295                 300                 


Tyr Val Phe Val Gly Glu Arg Phe Arg Arg Asp Leu Val Lys Thr Leu 
305                 310                 315                 320 


Lys Asn Leu Gly Cys Ile Ser Gln Ala Gln Trp Val Ser Phe Thr Arg 
                325                 330                 335     


Arg Glu Gly Ser Leu Lys Leu Ser Ser Met Leu Leu Glu Thr Thr Ser 
            340                 345                 350         


Gly Ala Leu Ser Leu 
        355         


<210>  3536
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  3536

Met Ala Ala Glu Asp Val Val Ala Thr Gly Ala Asp Pro Ser Asp Leu 
1               5                   10                  15      


Glu Ser Gly Gly Leu Leu His Glu Ile Phe Thr Ser Pro Leu Asn Leu 
            20                  25                  30          


Leu Leu Leu Gly Leu Cys Ile Phe Leu Leu Tyr Lys Ile Val Arg Gly 
        35                  40                  45              


Asp Gln Pro Ala Ala Ser Gly Asp Ser Asp Asp Asp Glu Pro Pro Pro 
    50                  55                  60                  


Leu Pro Arg Leu Lys Arg Arg Asp Phe Thr Pro Ala Glu Leu Arg Arg 
65                  70                  75                  80  


Phe Asp Gly Val Gln Asp Pro Arg Ile Leu Met Ala Ile Asn Gly Lys 
                85                  90                  95      


Val Phe Asp Val Thr Lys Gly Arg Lys Phe Tyr Gly Pro Glu Gly Pro 
            100                 105                 110         


Tyr Gly Val Phe Ala Gly Arg Asp Ala Ser Arg Gly Leu Ala Thr Phe 
        115                 120                 125             


Cys Leu Asp Lys Glu Ala Leu Lys Asp Glu Tyr Asp Asp Leu Ser Asp 
    130                 135                 140                 


Leu Thr Ala Ala Gln Gln Glu Thr Leu Ser Asp Trp Glu Ser Gln Phe 
145                 150                 155                 160 


Thr Phe Lys Tyr His His Val Gly Lys Leu Leu Lys Glu Gly Glu Glu 
                165                 170                 175     


Pro Thr Val Tyr Ser Asp Glu Glu Glu Pro Lys Asp Glu Ser Ala Arg 
            180                 185                 190         


Lys Asn Asp 
        195 


<210>  3537
<211>  650
<212>  PRT
<213>  Homo sapiens

<400>  3537

Met Thr Pro Ile Leu Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Val Gln Ala Gly His Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Arg 
        35                  40                  45              


Cys Gln Gly Gly Gln Glu Thr Gln Glu Tyr Arg Leu Tyr Arg Glu Lys 
    50                  55                  60                  


Lys Thr Ala Pro Trp Ile Thr Arg Ile Pro Gln Glu Leu Val Lys Lys 
65                  70                  75                  80  


Gly Gln Phe Pro Ile Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr 
                85                  90                  95      


Arg Cys Tyr Tyr Gly Ser Asp Thr Ala Gly Arg Ser Glu Ser Ser Asp 
            100                 105                 110         


Pro Leu Glu Leu Val Val Thr Gly Ala Tyr Ile Lys Pro Thr Leu Ser 
        115                 120                 125             


Ala Gln Pro Ser Pro Val Val Asn Ser Gly Gly Asn Val Thr Leu Gln 
    130                 135                 140                 


Cys Asp Ser Gln Val Ala Phe Asp Gly Phe Ile Leu Cys Lys Glu Gly 
145                 150                 155                 160 


Glu Asp Glu His Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly 
                165                 170                 175     


Ser Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Ser Arg Arg 
            180                 185                 190         


Trp Trp Tyr Arg Cys Tyr Ala Tyr Asp Ser Asn Ser Pro Tyr Glu Trp 
        195                 200                 205             


Ser Leu Pro Ser Asp Leu Leu Glu Leu Leu Val Leu Gly Val Ser Lys 
    210                 215                 220                 


Lys Pro Ser Leu Ser Val Gln Pro Gly Pro Ile Val Ala Pro Glu Glu 
225                 230                 235                 240 


Thr Leu Thr Leu Gln Cys Gly Ser Asp Ala Gly Tyr Asn Arg Phe Val 
                245                 250                 255     


Leu Tyr Lys Asp Gly Glu Arg Asp Phe Leu Gln Leu Ala Gly Ala Gln 
            260                 265                 270         


Pro Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser 
        275                 280                 285             


Arg Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser 
    290                 295                 300                 


Ser Glu Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Ala Gly 
305                 310                 315                 320 


Gln Phe Tyr Asp Arg Val Ser Leu Ser Val Gln Pro Gly Pro Thr Val 
                325                 330                 335     


Ala Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Gln Gly Trp Met 
            340                 345                 350         


Gln Thr Phe Leu Leu Thr Lys Glu Gly Ala Ala Asp Asp Pro Trp Arg 
        355                 360                 365             


Leu Arg Ser Thr Tyr Gln Ser Gln Lys Tyr Gln Ala Glu Phe Pro Met 
    370                 375                 380                 


Gly Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser 
385                 390                 395                 400 


Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp Pro Leu Glu 
                405                 410                 415     


Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly 
            420                 425                 430         


Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly 
        435                 440                 445             


Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly 
    450                 455                 460                 


Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe 
465                 470                 475                 480 


Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln 
                485                 490                 495     


Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro 
            500                 505                 510         


Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln 
        515                 520                 525             


Glu Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly 
    530                 535                 540                 


Val Glu Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val 
545                 550                 555                 560 


Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser 
                565                 570                 575     


Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln 
            580                 585                 590         


Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala 
        595                 600                 605             


Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg 
    610                 615                 620                 


Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val 
625                 630                 635                 640 


Pro Ser Ile Tyr Ala Thr Leu Ala Ile His 
                645                 650 


<210>  3538
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  3538

Met Pro Gly Gly Cys Ser Arg Gly Pro Ala Ala Gly Asp Gly Arg Leu 
1               5                   10                  15      


Arg Leu Ala Arg Leu Ala Leu Val Leu Leu Gly Trp Val Ser Ser Ser 
            20                  25                  30          


Ser Pro Thr Ser Ser Ala Ser Ser Phe Ser Ser Ser Ala Pro Phe Leu 
        35                  40                  45              


Ala Ser Ala Val Ser Ala Gln Pro Pro Leu Pro Asp Gln Cys Pro Ala 
    50                  55                  60                  


Leu Cys Glu Cys Ser Glu Ala Ala Arg Thr Val Lys Cys Val Asn Arg 
65                  70                  75                  80  


Asn Leu Thr Glu Val Pro Thr Asp Leu Pro Ala Tyr Val Arg Asn Leu 
                85                  90                  95      


Phe Leu Thr Gly Asn Gln Leu Ala Val Leu Pro Ala Gly Ala Phe Ala 
            100                 105                 110         


Arg Arg Pro Pro Leu Ala Glu Leu Ala Ala Leu Asn Leu Ser Gly Ser 
        115                 120                 125             


Arg Leu Asp Glu Val Arg Ala Gly Ala Phe Glu His Leu Pro Ser Leu 
    130                 135                 140                 


Arg Gln Leu Asp Leu Ser His Asn Pro Leu Ala Asp Leu Ser Pro Phe 
145                 150                 155                 160 


Ala Phe Ser Gly Ser Asn Ala Ser Val Ser Ala Pro Ser Pro Leu Val 
                165                 170                 175     


Glu Leu Ile Leu Asn His Ile Val Pro Pro Glu Asp Glu Arg Gln Asn 
            180                 185                 190         


Arg Ser Phe Glu Gly Met Val Val Ala Ala Leu Leu Ala Gly Arg Ala 
        195                 200                 205             


Leu Gln Gly Leu Arg Arg Leu Glu Leu Ala Ser Asn His Phe Leu Tyr 
    210                 215                 220                 


Leu Pro Arg Asp Val Leu Ala Gln Leu Pro Ser Leu Arg His Leu Asp 
225                 230                 235                 240 


Leu Ser Asn Asn Ser Leu Val Ser Leu Thr Tyr Val Ser Phe Arg Asn 
                245                 250                 255     


Leu Thr His Leu Glu Ser Leu His Leu Glu Asp Asn Ala Leu Lys Val 
            260                 265                 270         


Leu His Asn Gly Thr Leu Ala Glu Leu Gln Gly Leu Pro His Ile Arg 
        275                 280                 285             


Val Phe Leu Asp Asn Asn Pro Trp Val Cys Asp Cys His Met Ala Asp 
    290                 295                 300                 


Met Val Thr Trp Leu Lys Glu Thr Glu Val Val Gln Gly Lys Asp Arg 
305                 310                 315                 320 


Leu Thr Cys Ala Tyr Pro Glu Lys Met Arg Asn Arg Val Leu Leu Glu 
                325                 330                 335     


Leu Asn Ser Ala Asp Leu Asp Cys Asp Pro Ile Leu Pro Pro Ser Leu 
            340                 345                 350         


Gln Thr Ser Tyr Val Phe Leu Gly Ile Val Leu Ala Leu Ile Gly Ala 
        355                 360                 365             


Ile Phe Leu Leu Val Leu Tyr Leu Asn Arg Lys Gly Ile Lys Lys Trp 
    370                 375                 380                 


Met His Asn Ile Arg Asp Ala Cys Arg Asp His Met Glu Gly Tyr His 
385                 390                 395                 400 


Tyr Arg Tyr Glu Ile Asn Ala Asp Pro Arg Leu Thr Asn Leu Ser Ser 
                405                 410                 415     


Asn Ser Asp Val 
            420 


<210>  3539
<211>  560
<212>  PRT
<213>  Homo sapiens

<400>  3539

Met Val Pro His Ala Ile Leu Ala Arg Gly Arg Asp Val Cys Arg Arg 
1               5                   10                  15      


Asn Gly Leu Leu Ile Leu Ser Val Leu Ser Val Ile Val Gly Cys Leu 
            20                  25                  30          


Leu Gly Phe Phe Leu Arg Thr Arg Arg Leu Ser Pro Gln Glu Ile Ser 
        35                  40                  45              


Tyr Phe Gln Phe Pro Gly Glu Leu Leu Met Arg Met Leu Lys Met Met 
    50                  55                  60                  


Ile Leu Pro Leu Val Val Ser Ser Leu Met Ser Gly Leu Ala Ser Leu 
65                  70                  75                  80  


Asp Ala Lys Thr Ser Ser Arg Leu Gly Val Leu Thr Val Ala Tyr Tyr 
                85                  90                  95      


Leu Trp Thr Thr Phe Met Ala Val Ile Val Gly Ile Phe Met Val Ser 
            100                 105                 110         


Ile Ile His Pro Gly Ser Ala Ala Gln Lys Glu Thr Thr Glu Gln Ser 
        115                 120                 125             


Gly Lys Pro Ile Met Ser Ser Ala Asp Ala Leu Leu Asp Leu Ile Arg 
    130                 135                 140                 


Asn Met Phe Pro Ala Asn Leu Val Glu Ala Thr Phe Lys Gln Tyr Arg 
145                 150                 155                 160 


Thr Lys Thr Thr Pro Val Val Lys Ser Pro Lys Val Ala Pro Glu Glu 
                165                 170                 175     


Ala Pro Pro Arg Arg Ile Leu Ile Tyr Gly Val Gln Glu Glu Asn Gly 
            180                 185                 190         


Ser His Val Gln Asn Phe Ala Leu Asp Leu Thr Pro Pro Pro Glu Val 
        195                 200                 205             


Val Tyr Lys Ser Glu Pro Gly Thr Ser Asp Gly Met Asn Val Leu Gly 
    210                 215                 220                 


Ile Val Phe Phe Ser Ala Thr Met Gly Ile Met Leu Gly Arg Met Gly 
225                 230                 235                 240 


Asp Ser Gly Ala Pro Leu Val Ser Phe Cys Gln Cys Leu Asn Glu Ser 
                245                 250                 255     


Val Met Lys Ile Val Ala Val Ala Val Trp Tyr Phe Pro Phe Gly Ile 
            260                 265                 270         


Val Phe Leu Ile Ala Gly Lys Ile Leu Glu Met Asp Asp Pro Arg Ala 
        275                 280                 285             


Val Gly Lys Lys Leu Gly Phe Tyr Ser Val Thr Val Val Cys Gly Leu 
    290                 295                 300                 


Val Leu His Gly Leu Phe Ile Leu Pro Leu Leu Tyr Phe Phe Ile Thr 
305                 310                 315                 320 


Lys Lys Asn Pro Ile Val Phe Ile Arg Gly Ile Leu Gln Ala Leu Leu 
                325                 330                 335     


Ile Ala Leu Ala Thr Ser Ser Ser Ser Ala Thr Leu Pro Ile Thr Phe 
            340                 345                 350         


Lys Cys Leu Leu Glu Asn Asn His Ile Asp Arg Arg Ile Ala Arg Phe 
        355                 360                 365             


Val Leu Pro Val Gly Ala Thr Ile Asn Met Asp Gly Thr Ala Leu Tyr 
    370                 375                 380                 


Glu Ala Val Ala Ala Ile Phe Ile Ala Gln Val Asn Asn Tyr Glu Leu 
385                 390                 395                 400 


Asp Phe Gly Gln Ile Ile Thr Ile Ser Ile Thr Ala Thr Ala Ala Ser 
                405                 410                 415     


Ile Gly Ala Ala Gly Ile Pro Gln Ala Gly Leu Val Thr Met Val Ile 
            420                 425                 430         


Val Leu Thr Ser Val Gly Leu Pro Thr Asp Asp Ile Thr Leu Ile Ile 
        435                 440                 445             


Ala Val Asp Trp Ala Leu Asp Arg Phe Arg Thr Met Ile Asn Val Leu 
    450                 455                 460                 


Gly Asp Ala Leu Ala Ala Gly Ile Met Ala His Ile Cys Arg Lys Asp 
465                 470                 475                 480 


Phe Ala Arg Asp Thr Gly Thr Glu Lys Leu Leu Pro Cys Glu Thr Lys 
                485                 490                 495     


Pro Val Ser Leu Gln Glu Ile Val Ala Ala Gln Gln Asn Gly Cys Val 
            500                 505                 510         


Lys Ser Val Ala Glu Ala Ser Glu Leu Thr Leu Gly Pro Thr Cys Pro 
        515                 520                 525             


His His Val Pro Val Gln Val Glu Gln Asp Glu Glu Leu Pro Ala Ala 
    530                 535                 540                 


Ser Leu Asn His Cys Thr Ile Gln Ile Ser Glu Leu Glu Thr Asn Val 
545                 550                 555                 560 


<210>  3540
<211>  546
<212>  PRT
<213>  Homo sapiens

<400>  3540

Met Gly Phe Glu Glu Leu Leu Glu Gln Val Gly Gly Phe Gly Pro Phe 
1               5                   10                  15      


Gln Leu Arg Asn Val Ala Leu Leu Ala Leu Pro Arg Val Leu Leu Pro 
            20                  25                  30          


Leu His Phe Leu Leu Pro Ile Phe Leu Ala Ala Val Pro Ala His Arg 
        35                  40                  45              


Cys Ala Leu Pro Gly Ala Pro Ala Asn Phe Ser His Gln Asp Val Trp 
    50                  55                  60                  


Leu Glu Ala His Leu Pro Arg Glu Pro Asp Gly Thr Leu Ser Ser Cys 
65                  70                  75                  80  


Leu Arg Phe Ala Tyr Pro Gln Ala Leu Pro Asn Thr Thr Leu Gly Glu 
                85                  90                  95      


Glu Arg Gln Ser Arg Gly Glu Leu Glu Asp Glu Pro Ala Thr Val Pro 
            100                 105                 110         


Cys Ser Gln Gly Trp Glu Tyr Asp His Ser Glu Phe Ser Ser Thr Ile 
        115                 120                 125             


Ala Thr Glu Trp Asp Leu Val Cys Glu Gln Lys Gly Leu Asn Arg Ala 
    130                 135                 140                 


Ala Ser Thr Phe Phe Phe Ala Gly Val Leu Val Gly Ala Val Ala Phe 
145                 150                 155                 160 


Gly Tyr Leu Ser Asp Arg Phe Gly Arg Arg Arg Leu Leu Leu Val Ala 
                165                 170                 175     


Tyr Val Ser Thr Leu Val Leu Gly Leu Ala Ser Ala Ala Ser Val Ser 
            180                 185                 190         


Tyr Val Met Phe Ala Ile Thr Arg Thr Leu Thr Gly Ser Ala Leu Ala 
        195                 200                 205             


Gly Phe Thr Ile Ile Val Met Pro Leu Glu Leu Glu Trp Leu Asp Val 
    210                 215                 220                 


Glu His Arg Thr Val Ala Gly Val Leu Ser Ser Thr Phe Trp Thr Gly 
225                 230                 235                 240 


Gly Val Met Leu Leu Ala Leu Val Gly Tyr Leu Ile Arg Asp Trp Arg 
                245                 250                 255     


Trp Leu Leu Leu Ala Val Thr Leu Pro Cys Ala Pro Gly Ile Leu Ser 
            260                 265                 270         


Leu Trp Trp Val Pro Glu Ser Ala Arg Trp Leu Leu Thr Gln Gly His 
        275                 280                 285             


Val Lys Glu Ala His Arg Tyr Leu Leu His Cys Ala Arg Leu Asn Gly 
    290                 295                 300                 


Arg Pro Val Cys Glu Asp Ser Phe Ser Gln Glu Ala Val Ser Lys Val 
305                 310                 315                 320 


Ala Ala Gly Glu Arg Val Val Arg Arg Pro Ser Tyr Leu Asp Leu Phe 
                325                 330                 335     


Arg Thr Pro Arg Leu Arg His Ile Ser Leu Cys Cys Val Val Val Trp 
            340                 345                 350         


Phe Gly Val Asn Phe Ser Tyr Tyr Gly Leu Ser Leu Asp Val Ser Gly 
        355                 360                 365             


Leu Gly Leu Asn Val Tyr Gln Thr Gln Leu Leu Phe Gly Ala Val Glu 
    370                 375                 380                 


Leu Pro Ser Lys Leu Leu Val Tyr Leu Ser Val Arg Tyr Ala Gly Arg 
385                 390                 395                 400 


Arg Leu Thr Gln Ala Gly Thr Leu Leu Gly Thr Ala Leu Ala Phe Gly 
                405                 410                 415     


Thr Arg Leu Leu Val Ser Ser Asp Met Lys Ser Trp Ser Thr Val Leu 
            420                 425                 430         


Ala Val Met Gly Lys Ala Phe Ser Glu Ala Ala Phe Thr Thr Ala Tyr 
        435                 440                 445             


Leu Phe Thr Ser Glu Leu Tyr Pro Thr Val Leu Arg Gln Thr Gly Met 
    450                 455                 460                 


Gly Leu Thr Ala Leu Val Gly Arg Leu Gly Gly Ser Leu Ala Pro Leu 
465                 470                 475                 480 


Ala Ala Leu Leu Asp Gly Val Trp Leu Ser Leu Pro Lys Leu Thr Tyr 
                485                 490                 495     


Gly Gly Ile Ala Leu Leu Ala Ala Gly Thr Ala Leu Leu Leu Pro Glu 
            500                 505                 510         


Thr Arg Gln Ala Gln Leu Pro Glu Thr Ile Gln Asp Val Glu Arg Lys 
        515                 520                 525             


Ser Ala Pro Thr Ser Leu Gln Glu Glu Glu Met Pro Met Lys Gln Val 
    530                 535                 540                 


Gln Asn 
545     


<210>  3541
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  3541

Met Ala Arg Gly Cys Leu Cys Cys Leu Lys Tyr Met Met Phe Leu Phe 
1               5                   10                  15      


Asn Leu Ile Phe Trp Leu Cys Gly Cys Gly Leu Leu Gly Val Gly Ile 
            20                  25                  30          


Trp Leu Ser Val Ser Gln Gly Asn Phe Ala Thr Phe Ser Pro Ser Phe 
        35                  40                  45              


Pro Ser Leu Ser Ala Ala Asn Leu Val Ile Ala Ile Gly Thr Ile Val 
    50                  55                  60                  


Met Val Thr Gly Phe Leu Gly Cys Leu Gly Ala Ile Lys Glu Asn Lys 
65                  70                  75                  80  


Cys Leu Leu Leu Ser Phe Phe Ile Val Leu Leu Val Ile Leu Leu Ala 
                85                  90                  95      


Glu Leu Ile Leu Leu Ile Leu Phe Phe Val Tyr Met Asp Lys Val Asn 
            100                 105                 110         


Glu Asn Ala Lys Lys Asp Leu Lys Glu Gly Leu Leu Leu Tyr His Thr 
        115                 120                 125             


Glu Asn Asn Val Gly Leu Lys Asn Ala Trp Asn Ile Ile Gln Ala Glu 
    130                 135                 140                 


Met Arg Cys Cys Gly Val Thr Asp Tyr Thr Asp Trp Tyr Pro Val Leu 
145                 150                 155                 160 


Gly Glu Asn Thr Val Pro Asp Arg Cys Cys Met Glu Asn Ser Gln Gly 
                165                 170                 175     


Cys Gly Arg Asn Ala Thr Thr Pro Leu Trp Arg Thr Gly Cys Tyr Glu 
            180                 185                 190         


Lys Val Lys Met Trp Phe Asp Asp Asn Lys His Val Leu Gly Thr Val 
        195                 200                 205             


Gly Met Cys Ile Leu Ile Met Gln Ile Leu Gly Met Ala Phe Ser Met 
    210                 215                 220                 


Thr Leu Phe Gln His Ile His Arg Thr Gly Lys Lys Tyr Asp Ala 
225                 230                 235                 


<210>  3542
<211>  1318
<212>  PRT
<213>  Homo sapiens

<400>  3542

Met Ser Gly Gly Ala Ser Ala Thr Gly Pro Arg Arg Gly Pro Pro Gly 
1               5                   10                  15      


Leu Glu Asp Thr Thr Ser Lys Lys Lys Gln Lys Asp Arg Ala Asn Gln 
            20                  25                  30          


Glu Ser Lys Asp Gly Asp Pro Arg Lys Glu Thr Gly Ser Arg Tyr Val 
        35                  40                  45              


Ala Gln Ala Gly Leu Glu Pro Leu Ala Ser Gly Asp Pro Ser Ala Ser 
    50                  55                  60                  


Ala Ser His Ala Ala Gly Ile Thr Gly Ser Arg His Arg Thr Arg Leu 
65                  70                  75                  80  


Phe Phe Pro Ser Ser Ser Gly Ser Ala Ser Thr Pro Gln Glu Glu Gln 
                85                  90                  95      


Thr Lys Glu Gly Ala Cys Glu Asp Pro His Asp Leu Leu Ala Thr Pro 
            100                 105                 110         


Thr Pro Glu Leu Leu Leu Asp Trp Arg Gln Ser Ala Glu Glu Val Ile 
        115                 120                 125             


Val Lys Leu Arg Val Gly Val Gly Pro Leu Gln Leu Glu Asp Val Asp 
    130                 135                 140                 


Ala Ala Phe Thr Asp Thr Asp Cys Val Val Arg Phe Ala Gly Gly Gln 
145                 150                 155                 160 


Gln Trp Gly Gly Val Phe Tyr Ala Glu Ile Lys Ser Ser Cys Ala Lys 
                165                 170                 175     


Val Gln Thr Arg Lys Gly Ser Leu Leu His Leu Thr Leu Pro Lys Lys 
            180                 185                 190         


Val Pro Met Leu Thr Trp Pro Ser Leu Leu Val Glu Ala Asp Glu Gln 
        195                 200                 205             


Leu Cys Ile Pro Pro Leu Asn Ser Gln Thr Cys Leu Leu Gly Ser Glu 
    210                 215                 220                 


Glu Asn Leu Ala Pro Leu Ala Gly Glu Lys Ala Val Pro Pro Gly Asn 
225                 230                 235                 240 


Asp Pro Val Ser Pro Ala Met Val Arg Ser Arg Asn Pro Gly Lys Asp 
                245                 250                 255     


Asp Cys Ala Lys Glu Glu Met Ala Val Ala Ala Asp Ala Ala Thr Leu 
            260                 265                 270         


Val Asp Glu Pro Glu Ser Met Val Asn Leu Ala Phe Val Lys Asn Asp 
        275                 280                 285             


Ser Tyr Glu Lys Gly Pro Asp Ser Val Val Val His Val Tyr Val Lys 
    290                 295                 300                 


Glu Ile Cys Arg Asp Thr Ser Arg Val Leu Phe Arg Glu Gln Asp Phe 
305                 310                 315                 320 


Thr Leu Ile Phe Gln Thr Arg Asp Gly Asn Phe Leu Arg Leu His Pro 
                325                 330                 335     


Gly Cys Gly Pro His Thr Thr Phe Arg Trp Gln Val Lys Leu Arg Asn 
            340                 345                 350         


Leu Ile Glu Pro Glu Gln Cys Thr Phe Cys Phe Thr Ala Ser Arg Ile 
        355                 360                 365             


Asp Ile Cys Leu Arg Lys Arg Gln Ser Gln Arg Trp Gly Gly Leu Glu 
    370                 375                 380                 


Ala Pro Ala Ala Arg Val Gly Gly Ala Lys Val Ala Val Pro Thr Gly 
385                 390                 395                 400 


Pro Thr Pro Leu Asp Ser Thr Pro Pro Gly Gly Ala Pro His Pro Leu 
                405                 410                 415     


Thr Gly Gln Glu Glu Ala Arg Ala Val Glu Lys Asp Lys Ser Lys Ala 
            420                 425                 430         


Arg Ser Glu Asp Thr Gly Leu Asp Ser Val Ala Thr Arg Thr Pro Met 
        435                 440                 445             


Glu His Val Thr Pro Lys Pro Glu Thr His Leu Ala Ser Pro Lys Pro 
    450                 455                 460                 


Thr Cys Met Val Pro Pro Met Pro His Ser Pro Val Ser Gly Asp Ser 
465                 470                 475                 480 


Val Glu Glu Glu Glu Glu Glu Glu Lys Lys Val Cys Leu Pro Gly Phe 
                485                 490                 495     


Thr Gly Leu Val Asn Leu Gly Asn Thr Cys Phe Met Asn Ser Val Ile 
            500                 505                 510         


Gln Ser Leu Ser Asn Thr Arg Glu Leu Arg Asp Phe Phe His Asp Arg 
        515                 520                 525             


Ser Phe Glu Ala Glu Ile Asn Tyr Asn Asn Pro Leu Gly Thr Gly Gly 
    530                 535                 540                 


Arg Leu Ala Ile Gly Phe Ala Val Leu Leu Arg Ala Leu Trp Lys Gly 
545                 550                 555                 560 


Thr His His Ala Phe Gln Pro Ser Lys Leu Lys Ala Ile Val Ala Ser 
                565                 570                 575     


Lys Ala Ser Gln Phe Thr Gly Tyr Ala Gln His Asp Ala Gln Glu Phe 
            580                 585                 590         


Met Ala Phe Leu Leu Asp Gly Leu His Glu Asp Leu Asn Arg Ile Gln 
        595                 600                 605             


Asn Lys Pro Tyr Thr Glu Thr Val Asp Ser Asp Gly Arg Pro Asp Glu 
    610                 615                 620                 


Val Val Ala Glu Glu Ala Trp Gln Arg His Lys Met Arg Asn Asp Ser 
625                 630                 635                 640 


Phe Ile Val Asp Leu Phe Gln Gly Gln Tyr Lys Ser Lys Leu Val Cys 
                645                 650                 655     


Pro Val Cys Ala Lys Val Ser Ile Thr Phe Asp Pro Phe Leu Tyr Leu 
            660                 665                 670         


Pro Val Pro Leu Pro Gln Lys Gln Lys Val Leu Pro Val Phe Tyr Phe 
        675                 680                 685             


Ala Arg Glu Pro His Ser Lys Pro Ile Lys Phe Leu Val Ser Val Ser 
    690                 695                 700                 


Lys Glu Asn Ser Thr Ala Ser Glu Val Leu Asp Ser Leu Ser Gln Ser 
705                 710                 715                 720 


Val His Val Lys Pro Glu Asn Leu Arg Leu Ala Glu Val Ile Lys Asn 
                725                 730                 735     


Arg Phe His Arg Val Phe Leu Pro Ser His Ser Leu Asp Thr Val Ser 
            740                 745                 750         


Pro Ser Asp Thr Leu Leu Cys Phe Glu Leu Leu Ser Ser Glu Leu Ala 
        755                 760                 765             


Lys Glu Arg Val Val Val Leu Glu Val Gln Gln Arg Pro Gln Val Pro 
    770                 775                 780                 


Ser Val Pro Ile Ser Lys Cys Ala Ala Cys Gln Arg Lys Gln Gln Ser 
785                 790                 795                 800 


Glu Asp Glu Lys Leu Lys Arg Cys Thr Arg Cys Tyr Arg Val Gly Tyr 
                805                 810                 815     


Cys Asn Gln Leu Cys Gln Lys Thr His Trp Pro Asp His Lys Gly Leu 
            820                 825                 830         


Cys Arg Pro Glu Asn Ile Gly Tyr Pro Phe Leu Val Ser Val Pro Ala 
        835                 840                 845             


Ser Arg Leu Thr Tyr Ala Arg Leu Ala Gln Leu Leu Glu Gly Tyr Ala 
    850                 855                 860                 


Arg Tyr Ser Val Ser Val Phe Gln Pro Pro Phe Gln Pro Gly Arg Met 
865                 870                 875                 880 


Ala Leu Glu Ser Gln Ser Pro Gly Cys Thr Thr Leu Leu Ser Thr Gly 
                885                 890                 895     


Ser Leu Glu Ala Gly Asp Ser Glu Arg Asp Pro Ile Gln Pro Pro Glu 
            900                 905                 910         


Leu Gln Leu Val Thr Pro Met Ala Glu Gly Asp Thr Gly Leu Pro Arg 
        915                 920                 925             


Val Trp Ala Ala Pro Asp Arg Gly Pro Val Pro Ser Thr Ser Gly Ile 
    930                 935                 940                 


Ser Ser Glu Met Leu Ala Ser Gly Pro Ile Glu Val Gly Ser Leu Pro 
945                 950                 955                 960 


Ala Gly Glu Arg Val Ser Arg Pro Glu Ala Ala Val Pro Gly Tyr Gln 
                965                 970                 975     


His Pro Ser Glu Ala Met Asn Ala His Thr Pro Gln Phe Phe Ile Tyr 
            980                 985                 990         


Lys Ile Asp Ser Ser Asn Arg Glu  Gln Arg Leu Glu Asp  Lys Gly Asp 
        995                 1000                 1005             


Thr Pro  Leu Glu Leu Gly Asp  Asp Cys Ser Leu Ala  Leu Val Trp 
    1010                 1015                 1020             


Arg Asn  Asn Glu Arg Leu Gln  Glu Phe Val Leu Val  Ala Ser Lys 
    1025                 1030                 1035             


Glu Leu  Glu Cys Ala Glu Asp  Pro Gly Ser Ala Gly  Glu Ala Ala 
    1040                 1045                 1050             


Arg Ala  Gly His Phe Thr Leu  Asp Gln Cys Leu Asn  Leu Phe Thr 
    1055                 1060                 1065             


Arg Pro  Glu Val Leu Ala Pro  Glu Glu Ala Trp Tyr  Cys Pro Gln 
    1070                 1075                 1080             


Cys Lys  Gln His Arg Glu Ala  Ser Lys Gln Leu Leu  Leu Trp Arg 
    1085                 1090                 1095             


Leu Pro  Asn Val Leu Ile Val  Gln Leu Lys Arg Phe  Ser Phe Arg 
    1100                 1105                 1110             


Ser Phe  Ile Trp Arg Asp Lys  Ile Asn Asp Leu Val  Glu Phe Pro 
    1115                 1120                 1125             


Val Arg  Asn Leu Asp Leu Ser  Lys Phe Cys Ile Gly  Gln Lys Glu 
    1130                 1135                 1140             


Glu Gln  Leu Pro Ser Tyr Asp  Leu Tyr Ala Val Ile  Asn His Tyr 
    1145                 1150                 1155             


Gly Gly  Met Ile Gly Gly His  Tyr Thr Ala Cys Ala  Arg Leu Pro 
    1160                 1165                 1170             


Asn Asp  Arg Ser Ser Gln Arg  Ser Asp Val Gly Trp  Arg Leu Phe 
    1175                 1180                 1185             


Asp Asp  Ser Thr Val Thr Thr  Val Asp Glu Ser Gln  Val Val Thr 
    1190                 1195                 1200             


Arg Tyr  Ala Tyr Val Leu Phe  Tyr Arg Arg Arg Asn  Ser Pro Val 
    1205                 1210                 1215             


Glu Arg  Pro Pro Arg Ala Gly  His Ser Glu His His  Pro Asp Leu 
    1220                 1225                 1230             


Gly Pro  Ala Ala Glu Ala Ala  Ala Ser Gln Ala Ser  Arg Ile Trp 
    1235                 1240                 1245             


Gln Glu  Leu Glu Ala Glu Glu  Glu Pro Val Pro Glu  Gly Ser Gly 
    1250                 1255                 1260             


Pro Leu  Gly Pro Trp Gly Pro  Gln Asp Trp Val Gly  Pro Leu Pro 
    1265                 1270                 1275             


Arg Gly  Pro Thr Thr Pro Asp  Glu Gly Cys Leu Arg  Tyr Phe Val 
    1280                 1285                 1290             


Leu Gly  Thr Val Ala Ala Leu  Val Ala Leu Val Leu  Asn Val Phe 
    1295                 1300                 1305             


Tyr Pro  Leu Val Ser Gln Ser  Arg Trp Arg 
    1310                 1315             


<210>  3543
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  3543

Met Thr Ala Arg Ala Trp Ala Ser Trp Arg Ser Ser Ala Leu Leu Leu 
1               5                   10                  15      


Leu Leu Val Pro Gly Tyr Phe Pro Leu Ser His Pro Met Thr Val Ala 
            20                  25                  30          


Gly Pro Val Gly Gly Ser Leu Ser Val Gln Cys Arg Tyr Glu Lys Glu 
        35                  40                  45              


His Arg Thr Leu Asn Lys Phe Trp Cys Arg Pro Pro Gln Ile Leu Arg 
    50                  55                  60                  


Cys Asp Lys Ile Val Glu Thr Lys Gly Ser Ala Gly Lys Arg Asn Gly 
65                  70                  75                  80  


Arg Val Ser Ile Arg Asp Ser Pro Ala Asn Leu Ser Phe Thr Val Thr 
                85                  90                  95      


Leu Glu Asn Leu Thr Glu Glu Asp Ala Gly Thr Tyr Trp Cys Gly Val 
            100                 105                 110         


Asp Thr Pro Trp Leu Arg Asp Phe His Asp Pro Ile Val Glu Val Glu 
        115                 120                 125             


Val Ser Val Phe Pro Ala Gly Thr Thr Thr Ala Ser Ser Pro Gln Ser 
    130                 135                 140                 


Ser Met Gly Thr Ser Gly Pro Pro Thr Lys Leu Pro Val His Thr Trp 
145                 150                 155                 160 


Pro Ser Val Thr Arg Lys Asp Ser Pro Glu Pro Ser Pro His Pro Gly 
                165                 170                 175     


Ser Leu Phe Ser Asn Val Arg Phe Leu Leu Leu Val Leu Leu Glu Leu 
            180                 185                 190         


Pro Leu Leu Leu Ser Met Leu Gly Ala Val Leu Trp Val Asn Arg Pro 
        195                 200                 205             


Gln Arg Ser Ser Arg Ser Arg Gln Asn Trp Pro Lys Gly Glu Asn Gln 
    210                 215                 220                 


<210>  3544
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  3544

Met Leu Arg Thr Glu Ser Cys Arg Pro Arg Ser Pro Ala Gly Gln Val 
1               5                   10                  15      


Ala Ala Ala Ser Pro Leu Leu Leu Leu Leu Leu Leu Leu Ala Trp Cys 
            20                  25                  30          


Ala Gly Ala Cys Arg Gly Ala Pro Ile Leu Pro Gln Gly Leu Gln Pro 
        35                  40                  45              


Glu Gln Gln Leu Gln Leu Trp Asn Glu Ile Asp Asp Thr Cys Ser Ser 
    50                  55                  60                  


Phe Leu Ser Ile Asp Ser Gln Pro Gln Ala Ser Asn Ala Leu Glu Glu 
65                  70                  75                  80  


Leu Cys Phe Met Ile Met Gly Met Leu Pro Lys Pro Gln Glu Gln Asp 
                85                  90                  95      


Glu Lys Asp Asn Thr Lys Arg Phe Leu Phe His Tyr Ser Lys Thr Gln 
            100                 105                 110         


Lys Leu Gly Lys Ser Asn Val Val Ser Ser Val Val His Pro Leu Leu 
        115                 120                 125             


Gln Leu Val Pro His Leu His Glu Arg Arg Met Lys Arg Phe Arg Val 
    130                 135                 140                 


Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser Arg Gly Tyr Phe 
145                 150                 155                 160 


Leu Phe Arg Pro Arg Asn Gly Arg Arg Ser Ala Gly Phe Ile 
                165                 170                 


<210>  3545
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  3545

Met Thr Ser Ser Leu Lys Ile Trp Gly Ile Leu Leu Ala Leu Leu Cys 
1               5                   10                  15      


Ile Leu Cys Arg Leu Cys Val Tyr Ser Asn Asn Ile Tyr Trp Arg Glu 
            20                  25                  30          


Phe Ile Lys Leu His Tyr Leu Ser Pro Ser Arg Glu Phe Lys Glu Tyr 
        35                  40                  45              


Lys Cys Asp Val Leu Met Arg Glu Lys Glu Ala Leu Lys Gly Lys Ser 
    50                  55                  60                  


Phe His Met Phe Ile Tyr Ser Leu Trp Phe Lys Ile Gln Arg Ala Cys 
65                  70                  75                  80  


Ile Asn Glu Lys Gly Ser Asp Arg Tyr Arg Asn Ala Tyr Val Trp Ala 
                85                  90                  95      


Pro Gly Ala Leu Lys Val Leu Glu Cys His Trp Glu Lys Tyr Asn Asn 
            100                 105                 110         


Arg Tyr Thr Glu Ser Arg Ser Phe Ser Tyr Ile Glu Phe His Cys Gly 
        115                 120                 125             


Val Asp Gly Tyr Val Asp Asn Ile Glu Asp Leu Arg Ile Ile Glu Pro 
    130                 135                 140                 


Ile Ser Asn 
145         


<210>  3546
<211>  645
<212>  PRT
<213>  Homo sapiens

<400>  3546

Met Pro Arg Ser Arg Gly Gly Arg Ala Ala Pro Gly Pro Pro Pro Pro 
1               5                   10                  15      


Pro Pro Pro Pro Gly Gln Ala Pro Arg Trp Ser Arg Trp Arg Val Pro 
            20                  25                  30          


Gly Arg Leu Leu Leu Leu Leu Leu Pro Ala Leu Cys Cys Leu Pro Gly 
        35                  40                  45              


Ala Ala Arg Ala Ala Ala Ala Ala Ala Gly Ala Gly Asn Arg Ala Ala 
    50                  55                  60                  


Val Ala Val Ala Val Ala Arg Ala Asp Glu Ala Glu Ala Pro Phe Ala 
65                  70                  75                  80  


Gly Gln Asn Trp Leu Lys Ser Tyr Gly Tyr Leu Leu Pro Tyr Asp Ser 
                85                  90                  95      


Arg Ala Ser Ala Leu His Ser Ala Lys Ala Leu Gln Ser Ala Val Ser 
            100                 105                 110         


Thr Met Gln Gln Phe Tyr Gly Ile Pro Val Thr Gly Val Leu Asp Gln 
        115                 120                 125             


Thr Thr Ile Glu Trp Met Lys Lys Pro Arg Cys Gly Val Pro Asp His 
    130                 135                 140                 


Pro His Leu Ser Arg Arg Arg Arg Asn Lys Arg Tyr Ala Leu Thr Gly 
145                 150                 155                 160 


Gln Lys Trp Arg Gln Lys His Ile Thr Tyr Ser Ile His Asn Tyr Thr 
                165                 170                 175     


Pro Lys Val Gly Glu Leu Asp Thr Arg Lys Ala Ile Arg Gln Ala Phe 
            180                 185                 190         


Asp Val Trp Gln Lys Val Thr Pro Leu Thr Phe Glu Glu Val Pro Tyr 
        195                 200                 205             


His Glu Ile Lys Ser Asp Arg Lys Glu Ala Asp Ile Met Ile Phe Phe 
    210                 215                 220                 


Ala Ser Gly Phe His Gly Asp Ser Ser Pro Phe Asp Gly Glu Gly Gly 
225                 230                 235                 240 


Phe Leu Ala His Ala Tyr Phe Pro Gly Pro Gly Ile Gly Gly Asp Thr 
                245                 250                 255     


His Phe Asp Ser Asp Glu Pro Trp Thr Leu Gly Asn Ala Asn His Asp 
            260                 265                 270         


Gly Asn Asp Leu Phe Leu Val Ala Val His Glu Leu Gly His Ala Leu 
        275                 280                 285             


Gly Leu Glu His Ser Ser Asp Pro Ser Ala Ile Met Ala Pro Phe Tyr 
    290                 295                 300                 


Gln Tyr Met Glu Thr His Asn Phe Lys Leu Pro Gln Asp Asp Leu Gln 
305                 310                 315                 320 


Gly Ile Gln Lys Ile Tyr Gly Pro Pro Ala Glu Pro Leu Glu Pro Thr 
                325                 330                 335     


Arg Pro Leu Pro Thr Leu Pro Val Arg Arg Ile His Ser Pro Ser Glu 
            340                 345                 350         


Arg Lys His Glu Arg Gln Pro Arg Pro Pro Arg Pro Pro Leu Gly Asp 
        355                 360                 365             


Arg Pro Ser Thr Pro Gly Thr Lys Pro Asn Ile Cys Asp Gly Asn Phe 
    370                 375                 380                 


Asn Thr Val Ala Leu Phe Arg Gly Glu Met Phe Val Phe Lys Asp Arg 
385                 390                 395                 400 


Trp Phe Trp Arg Leu Arg Asn Asn Arg Val Gln Glu Gly Tyr Pro Met 
                405                 410                 415     


Gln Ile Glu Gln Phe Trp Lys Gly Leu Pro Ala Arg Ile Asp Ala Ala 
            420                 425                 430         


Tyr Glu Arg Ala Asp Gly Arg Phe Val Phe Phe Lys Gly Asp Lys Tyr 
        435                 440                 445             


Trp Val Phe Lys Glu Val Thr Val Glu Pro Gly Tyr Pro His Ser Leu 
    450                 455                 460                 


Gly Glu Leu Gly Ser Cys Leu Pro Arg Glu Gly Ile Asp Thr Ala Leu 
465                 470                 475                 480 


Arg Trp Glu Pro Val Gly Lys Thr Tyr Phe Phe Lys Gly Glu Arg Tyr 
                485                 490                 495     


Trp Arg Tyr Ser Glu Glu Arg Arg Ala Thr Asp Pro Gly Tyr Pro Lys 
            500                 505                 510         


Pro Ile Thr Val Trp Lys Gly Ile Pro Gln Ala Pro Gln Gly Ala Phe 
        515                 520                 525             


Ile Ser Lys Glu Gly Tyr Tyr Thr Tyr Phe Tyr Lys Gly Arg Asp Tyr 
    530                 535                 540                 


Trp Lys Phe Asp Asn Gln Lys Leu Ser Val Glu Pro Gly Tyr Pro Arg 
545                 550                 555                 560 


Asn Ile Leu Arg Asp Trp Met Gly Cys Asn Gln Lys Glu Val Glu Arg 
                565                 570                 575     


Arg Lys Glu Arg Arg Leu Pro Gln Asp Asp Val Asp Ile Met Val Thr 
            580                 585                 590         


Ile Asn Asp Val Pro Gly Ser Val Asn Ala Val Ala Val Val Ile Pro 
        595                 600                 605             


Cys Ile Leu Ser Leu Cys Ile Leu Val Leu Val Tyr Thr Ile Phe Gln 
    610                 615                 620                 


Phe Lys Asn Lys Thr Gly Pro Gln Pro Val Thr Tyr Tyr Lys Arg Pro 
625                 630                 635                 640 


Val Gln Glu Trp Val 
                645 


<210>  3547
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  3547

Met Ala Arg Cys Phe Ser Leu Val Leu Leu Leu Thr Ser Ile Trp Thr 
1               5                   10                  15      


Thr Arg Leu Leu Val Gln Gly Ser Leu Arg Ala Glu Glu Leu Ser Ile 
            20                  25                  30          


Gln Val Ser Cys Arg Ile Met Gly Ile Thr Leu Val Ser Lys Lys Ala 
        35                  40                  45              


Asn Gln Gln Leu Asn Phe Thr Glu Ala Lys Glu Ala Cys Arg Leu Leu 
    50                  55                  60                  


Gly Leu Ser Leu Ala Gly Lys Asp Gln Val Glu Thr Ala Leu Lys Ala 
65                  70                  75                  80  


Ser Phe Glu Thr Cys Ser Tyr Gly Trp Val Gly Asp Gly Phe Val Val 
                85                  90                  95      


Ile Ser Arg Ile Ser Pro Asn Pro Lys Cys Gly Lys Asn Gly Val Gly 
            100                 105                 110         


Val Leu Ile Trp Lys Val Pro Val Ser Arg Gln Phe Ala Ala Tyr Cys 
        115                 120                 125             


Tyr Asn Ser Ser Asp Thr Trp Thr Asn Ser Cys Ile Pro Glu Ile Ile 
    130                 135                 140                 


Thr Thr Lys Asp Pro Ile Phe Asn Thr Gln Thr Ala Thr Gln Thr Thr 
145                 150                 155                 160 


Glu Phe Ile Val Ser Asp Ser Thr Tyr Ser Val Ala Ser Pro Tyr Ser 
                165                 170                 175     


Thr Ile Pro Ala Pro Thr Thr Thr Pro Pro Ala Pro Ala Ser Thr Ser 
            180                 185                 190         


Ile Pro Arg Arg Lys Lys Leu Ile Cys Val Thr Glu Val Phe Met Glu 
        195                 200                 205             


Thr Ser Thr Met Ser Thr Glu Thr Glu Pro Phe Val Glu Asn Lys Ala 
    210                 215                 220                 


Ala Phe Lys Asn Glu Ala Ala Gly Phe Gly Gly Val Pro Thr Ala Leu 
225                 230                 235                 240 


Leu Val Leu Ala Leu Leu Phe Phe Gly Ala Ala Ala Gly Leu Gly Phe 
                245                 250                 255     


Cys Tyr Val Lys Arg Tyr Val Lys Ala Phe Pro Phe Thr Asn Lys Asn 
            260                 265                 270         


Gln Gln Lys Glu Met Ile Glu Thr Lys Val Val Lys Glu Glu Lys Ala 
        275                 280                 285             


Asn Asp Ser Asn Pro Asn Glu Glu Ser Lys Lys Thr Asp Lys Asn Pro 
    290                 295                 300                 


Glu Glu Ser Lys Ser Pro Ser Lys Thr Thr Val Arg Cys Leu Glu Ala 
305                 310                 315                 320 


Glu Val 
        


<210>  3548
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  3548

Met Leu Ala Gly Ala Gly Arg Pro Gly Leu Pro Gln Gly Arg His Leu 
1               5                   10                  15      


Cys Trp Leu Leu Cys Ala Phe Thr Leu Lys Leu Cys Gln Ala Glu Ala 
            20                  25                  30          


Pro Val Gln Glu Glu Lys Leu Ser Ala Ser Thr Ser Asn Leu Pro Cys 
        35                  40                  45              


Trp Leu Val Glu Glu Phe Val Val Ala Glu Glu Cys Ser Pro Cys Ser 
    50                  55                  60                  


Asn Phe Arg Ala Lys Thr Thr Pro Glu Cys Gly Pro Thr Gly Tyr Val 
65                  70                  75                  80  


Glu Lys Ile Thr Cys Ser Ser Ser Lys Arg Asn Glu Phe Lys Ser Cys 
                85                  90                  95      


Arg Ser Ala Leu Met Glu Gln Arg Leu Phe Trp Lys Phe Glu Gly Ala 
            100                 105                 110         


Val Val Cys Val Ala Leu Ile Phe Ala Cys Leu Val Ile Ile Arg Gln 
        115                 120                 125             


Arg Gln Leu Asp Arg Lys Ala Leu Glu Lys Val Arg Lys Gln Ile Glu 
    130                 135                 140                 


Ser Ile 
145     


<210>  3549
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  3549

Met Tyr Cys Leu Gln Trp Leu Leu Pro Val Leu Leu Ile Pro Lys Pro 
1               5                   10                  15      


Leu Asn Pro Ala Leu Trp Phe Ser His Ser Met Phe Met Gly Phe Tyr 
            20                  25                  30          


Leu Leu Ser Phe Leu Leu Glu Arg Lys Pro Cys Thr Ile Cys Ala Leu 
        35                  40                  45              


Val Phe Leu Ala Ala Leu Phe Leu Ile Cys Tyr Ser Cys Trp Gly Asn 
    50                  55                  60                  


Cys Phe Leu Tyr His Cys Ser Asp Ser Pro Leu Pro Glu Ser Ala His 
65                  70                  75                  80  


Asp Pro Gly Val Val Gly Thr 
                85          


<210>  3550
<211>  641
<212>  PRT
<213>  Homo sapiens

<400>  3550

Met Thr Thr Pro Ala Leu Leu Pro Leu Ser Gly Arg Arg Ile Pro Pro 
1               5                   10                  15      


Leu Asn Leu Gly Pro Pro Ser Phe Pro His His Arg Ala Thr Leu Arg 
            20                  25                  30          


Leu Ser Glu Lys Phe Ile Leu Leu Leu Ile Leu Ser Ala Phe Ile Thr 
        35                  40                  45              


Leu Cys Phe Gly Ala Phe Phe Phe Leu Pro Asp Ser Ser Lys His Lys 
    50                  55                  60                  


Arg Phe Asp Leu Gly Leu Glu Asp Val Leu Ile Pro His Val Asp Ala 
65                  70                  75                  80  


Gly Lys Gly Ala Lys Asn Pro Gly Val Phe Leu Ile His Gly Pro Asp 
                85                  90                  95      


Glu His Arg His Arg Glu Glu Glu Glu Arg Leu Arg Asn Lys Ile Arg 
            100                 105                 110         


Ala Asp His Glu Lys Ala Leu Glu Glu Ala Lys Glu Lys Leu Arg Lys 
        115                 120                 125             


Ser Arg Glu Glu Ile Arg Ala Glu Ile Gln Thr Glu Lys Asn Lys Val 
    130                 135                 140                 


Val Gln Glu Met Lys Ile Lys Glu Asn Lys Pro Leu Pro Pro Val Pro 
145                 150                 155                 160 


Ile Pro Asn Leu Val Gly Ile Arg Gly Gly Asp Pro Glu Asp Asn Asp 
                165                 170                 175     


Ile Arg Glu Lys Arg Glu Lys Ile Lys Glu Met Met Lys His Ala Trp 
            180                 185                 190         


Asp Asn Tyr Arg Thr Tyr Gly Trp Gly His Asn Glu Leu Arg Pro Ile 
        195                 200                 205             


Ala Arg Lys Gly His Ser Pro Asn Ile Phe Gly Ser Ser Gln Met Gly 
    210                 215                 220                 


Ala Thr Ile Val Asp Ala Leu Asp Thr Leu Tyr Ile Met Gly Leu His 
225                 230                 235                 240 


Asp Glu Phe Leu Asp Gly Gln Arg Trp Ile Glu Asp Asn Leu Asp Phe 
                245                 250                 255     


Ser Val Asn Ser Glu Val Ser Val Phe Glu Val Asn Ile Arg Phe Ile 
            260                 265                 270         


Gly Gly Leu Leu Ala Ala Tyr Tyr Leu Ser Gly Glu Glu Ile Phe Lys 
        275                 280                 285             


Ile Lys Ala Val Gln Leu Ala Glu Lys Leu Leu Pro Ala Phe Asn Thr 
    290                 295                 300                 


Pro Thr Gly Ile Pro Trp Ala Met Val Asn Leu Lys Ser Gly Val Gly 
305                 310                 315                 320 


Arg Asn Trp Gly Trp Ala Ser Ala Gly Ser Ser Ile Leu Ala Glu Phe 
                325                 330                 335     


Gly Thr Leu His Met Glu Phe Ile His Leu Ser Tyr Leu Thr Gly Asp 
            340                 345                 350         


Leu Thr Tyr Tyr Lys Lys Val Met His Ile Arg Lys Leu Leu Gln Lys 
        355                 360                 365             


Met Asp Arg Pro Asn Gly Leu Tyr Pro Asn Tyr Leu Asn Pro Arg Thr 
    370                 375                 380                 


Gly Arg Trp Gly Gln Tyr His Thr Ser Val Gly Gly Leu Gly Asp Ser 
385                 390                 395                 400 


Phe Tyr Glu Tyr Leu Leu Lys Ala Trp Leu Met Ser Asp Lys Thr Asp 
                405                 410                 415     


His Glu Ala Arg Lys Met Tyr Asp Asp Ala Ile Glu Ala Ile Glu Lys 
            420                 425                 430         


His Leu Ile Lys Lys Ser Arg Gly Gly Leu Thr Phe Ile Gly Glu Trp 
        435                 440                 445             


Lys Asn Gly His Leu Glu Lys Lys Met Gly His Leu Ala Cys Phe Ala 
    450                 455                 460                 


Gly Gly Met Phe Ala Leu Gly Ala Asp Gly Ser Arg Ala Asp Lys Ala 
465                 470                 475                 480 


Gly His Tyr Leu Glu Leu Gly Ala Glu Ile Ala Arg Thr Cys His Glu 
                485                 490                 495     


Ser Tyr Asp Arg Thr Ala Leu Lys Leu Gly Pro Glu Ser Phe Lys Phe 
            500                 505                 510         


Asp Gly Ala Val Glu Ala Val Ala Val Arg Gln Ala Glu Lys Tyr Tyr 
        515                 520                 525             


Ile Leu Arg Pro Glu Val Ile Glu Thr Tyr Trp Tyr Leu Trp Arg Phe 
    530                 535                 540                 


Thr His Asp Pro Arg Tyr Arg Gln Trp Gly Trp Glu Ala Ala Leu Ala 
545                 550                 555                 560 


Ile Glu Lys Tyr Cys Arg Val Asn Gly Gly Phe Ser Gly Val Lys Asp 
                565                 570                 575     


Val Tyr Ser Ser Thr Pro Thr His Asp Asp Val Gln Gln Ser Phe Phe 
            580                 585                 590         


Leu Ala Glu Thr Leu Lys Tyr Leu Tyr Leu Leu Phe Ser Gly Asp Asp 
        595                 600                 605             


Leu Leu Pro Leu Asp His Trp Val Phe Asn Thr Glu Ala His Pro Leu 
    610                 615                 620                 


Pro Val Leu His Leu Ala Asn Thr Thr Leu Ser Gly Asn Pro Ala Val 
625                 630                 635                 640 


Arg 
    


<210>  3551
<211>  1327
<212>  PRT
<213>  Homo sapiens

<400>  3551

Met Glu Ala Pro Leu Gln Thr Gly Met Val Leu Gly Val Met Ile Gly 
1               5                   10                  15      


Ala Gly Val Ala Val Val Val Thr Ala Val Leu Ile Leu Leu Val Val 
            20                  25                  30          


Arg Arg Leu Arg Val Pro Lys Thr Pro Ala Pro Asp Gly Pro Arg Tyr 
        35                  40                  45              


Arg Phe Arg Lys Arg Asp Lys Val Leu Phe Tyr Gly Arg Lys Ile Met 
    50                  55                  60                  


Arg Lys Val Ser Gln Ser Thr Ser Ser Leu Val Asp Thr Ser Val Ser 
65                  70                  75                  80  


Ala Thr Ser Arg Pro Arg Met Arg Lys Lys Leu Lys Met Leu Asn Ile 
                85                  90                  95      


Ala Lys Lys Ile Leu Arg Ile Gln Lys Glu Thr Pro Thr Leu Gln Arg 
            100                 105                 110         


Lys Glu Pro Pro Pro Ala Val Leu Glu Ala Asp Leu Thr Glu Gly Asp 
        115                 120                 125             


Leu Ala Asn Ser His Leu Pro Ser Glu Val Leu Tyr Met Leu Lys Asn 
    130                 135                 140                 


Val Arg Val Leu Gly His Phe Glu Lys Pro Leu Phe Leu Glu Leu Cys 
145                 150                 155                 160 


Arg His Met Val Phe Gln Arg Leu Gly Gln Gly Asp Tyr Val Phe Arg 
                165                 170                 175     


Pro Gly Gln Pro Asp Ala Ser Ile Tyr Val Val Gln Asp Gly Leu Leu 
            180                 185                 190         


Glu Leu Cys Leu Pro Gly Pro Asp Gly Lys Glu Cys Val Val Lys Glu 
        195                 200                 205             


Val Val Pro Gly Asp Ser Val Asn Ser Leu Leu Ser Ile Leu Asp Val 
    210                 215                 220                 


Ile Thr Gly His Gln His Pro Gln Arg Thr Val Ser Ala Arg Ala Ala 
225                 230                 235                 240 


Arg Asp Ser Thr Val Leu Arg Leu Pro Val Glu Ala Phe Ser Ala Val 
                245                 250                 255     


Phe Thr Lys Tyr Pro Glu Ser Leu Val Arg Val Val Gln Ile Ile Met 
            260                 265                 270         


Val Arg Leu Gln Arg Val Thr Phe Leu Ala Leu His Asn Tyr Leu Gly 
        275                 280                 285             


Leu Thr Asn Glu Leu Phe Ser His Glu Ile Gln Pro Leu Arg Leu Phe 
    290                 295                 300                 


Pro Ser Pro Gly Leu Pro Thr Arg Thr Ser Pro Val Arg Gly Ser Lys 
305                 310                 315                 320 


Arg Met Val Ser Thr Ser Ala Thr Asp Glu Pro Arg Glu Thr Pro Gly 
                325                 330                 335     


Arg Pro Pro Asp Pro Thr Gly Ala Pro Leu Pro Gly Pro Thr Gly Asp 
            340                 345                 350         


Pro Val Lys Pro Thr Ser Leu Glu Thr Pro Ser Ala Pro Leu Leu Ser 
        355                 360                 365             


Arg Cys Val Ser Met Pro Gly Asp Ile Ser Gly Leu Gln Gly Gly Pro 
    370                 375                 380                 


Arg Ser Asp Phe Asp Met Ala Tyr Glu Arg Gly Arg Ile Ser Val Ser 
385                 390                 395                 400 


Leu Gln Glu Glu Ala Ser Gly Gly Ser Leu Ala Ala Pro Ala Arg Thr 
                405                 410                 415     


Pro Thr Gln Glu Pro Arg Glu Gln Pro Ala Gly Ala Cys Glu Tyr Ser 
            420                 425                 430         


Tyr Cys Glu Asp Glu Ser Ala Thr Gly Gly Cys Pro Phe Gly Pro Tyr 
        435                 440                 445             


Gln Gly Arg Gln Thr Ser Ser Ile Phe Glu Ala Ala Lys Gln Glu Leu 
    450                 455                 460                 


Ala Lys Leu Met Arg Ile Glu Asp Pro Ser Leu Leu Asn Ser Arg Val 
465                 470                 475                 480 


Leu Leu His His Ala Lys Ala Gly Thr Ile Ile Ala Arg Gln Gly Asp 
                485                 490                 495     


Gln Asp Val Ser Leu His Phe Val Leu Trp Gly Cys Leu His Val Tyr 
            500                 505                 510         


Gln Arg Met Ile Asp Lys Ala Glu Asp Val Cys Leu Phe Val Ala Gln 
        515                 520                 525             


Pro Gly Glu Leu Val Gly Gln Leu Ala Val Leu Thr Gly Glu Pro Leu 
    530                 535                 540                 


Ile Phe Thr Leu Arg Ala Gln Arg Asp Cys Thr Phe Leu Arg Ile Ser 
545                 550                 555                 560 


Lys Ser Asp Phe Tyr Glu Ile Met Arg Ala Gln Pro Ser Val Val Leu 
                565                 570                 575     


Ser Ala Ala His Thr Val Ala Ala Arg Met Ser Pro Phe Val Arg Gln 
            580                 585                 590         


Met Asp Phe Ala Ile Asp Trp Thr Ala Val Glu Ala Gly Arg Ala Leu 
        595                 600                 605             


Tyr Arg Gln Gly Asp Arg Ser Asp Cys Thr Tyr Ile Val Leu Asn Gly 
    610                 615                 620                 


Arg Leu Arg Ser Val Ile Gln Arg Gly Ser Gly Lys Lys Glu Leu Val 
625                 630                 635                 640 


Gly Glu Tyr Gly Arg Gly Asp Leu Ile Gly Val Val Glu Ala Leu Thr 
                645                 650                 655     


Arg Gln Pro Arg Ala Thr Thr Val His Ala Val Arg Asp Thr Glu Leu 
            660                 665                 670         


Ala Lys Leu Pro Glu Gly Thr Leu Gly His Ile Lys Arg Arg Tyr Pro 
        675                 680                 685             


Gln Val Val Thr Arg Leu Ile His Leu Leu Ser Gln Lys Ile Leu Gly 
    690                 695                 700                 


Asn Leu Gln Gln Leu Gln Gly Pro Phe Pro Ala Gly Ser Gly Leu Gly 
705                 710                 715                 720 


Val Pro Pro His Ser Glu Leu Thr Asn Pro Ala Ser Asn Leu Ala Thr 
                725                 730                 735     


Val Ala Ile Leu Pro Val Cys Ala Glu Val Pro Met Val Ala Phe Thr 
            740                 745                 750         


Leu Glu Leu Gln His Ala Leu Gln Ala Ile Gly Pro Thr Leu Leu Leu 
        755                 760                 765             


Asn Ser Asp Ile Ile Arg Ala Arg Leu Gly Ala Ser Ala Leu Asp Ser 
    770                 775                 780                 


Ile Gln Glu Phe Arg Leu Ser Gly Trp Leu Ala Gln Gln Glu Asp Ala 
785                 790                 795                 800 


His Arg Ile Val Leu Tyr Gln Thr Asp Ala Ser Leu Thr Pro Trp Thr 
                805                 810                 815     


Val Arg Cys Leu Arg Gln Ala Asp Cys Ile Leu Ile Val Gly Leu Gly 
            820                 825                 830         


Asp Gln Glu Pro Thr Leu Gly Gln Leu Glu Gln Met Leu Glu Asn Thr 
        835                 840                 845             


Ala Val Arg Ala Leu Lys Gln Leu Val Leu Leu His Arg Glu Glu Gly 
    850                 855                 860                 


Ala Gly Pro Thr Arg Thr Val Glu Trp Leu Asn Met Arg Ser Trp Cys 
865                 870                 875                 880 


Ser Gly His Leu His Leu Arg Cys Pro Arg Arg Leu Phe Ser Arg Arg 
                885                 890                 895     


Ser Pro Ala Lys Leu His Glu Leu Tyr Glu Lys Val Phe Ser Arg Arg 
            900                 905                 910         


Ala Asp Arg His Ser Asp Phe Ser Arg Leu Ala Arg Val Leu Thr Gly 
        915                 920                 925             


Asn Thr Ile Ala Leu Val Leu Gly Gly Gly Gly Ala Arg Gly Cys Ser 
    930                 935                 940                 


His Ile Gly Val Leu Lys Ala Leu Glu Glu Ala Gly Val Pro Val Asp 
945                 950                 955                 960 


Leu Val Gly Gly Thr Ser Ile Gly Ser Phe Ile Gly Ala Leu Tyr Ala 
                965                 970                 975     


Glu Glu Arg Ser Ala Ser Arg Thr Lys Gln Arg Ala Arg Glu Trp Ala 
            980                 985                 990         


Lys Ser Met Thr Ser Val Leu Glu  Pro Val Leu Asp Leu  Thr Tyr Pro 
        995                 1000                 1005             


Val Thr  Ser Met Phe Thr Gly  Ser Ala Phe Asn Arg  Ser Ile His 
    1010                 1015                 1020             


Arg Val  Phe Gln Asp Lys Gln  Ile Glu Asp Leu Trp  Leu Pro Tyr 
    1025                 1030                 1035             


Phe Asn  Val Thr Thr Asp Ile  Thr Ala Ser Ala Met  Arg Val His 
    1040                 1045                 1050             


Lys Asp  Gly Ser Leu Trp Arg  Tyr Val Arg Ala Ser  Met Thr Leu 
    1055                 1060                 1065             


Ser Gly  Tyr Leu Pro Pro Leu  Cys Asp Pro Lys Asp  Gly His Leu 
    1070                 1075                 1080             


Leu Met  Asp Gly Gly Tyr Ile  Asn Asn Leu Pro Ala  Asp Ile Ala 
    1085                 1090                 1095             


Arg Ser  Met Gly Ala Lys Thr  Val Ile Ala Ile Asp  Val Gly Ser 
    1100                 1105                 1110             


Gln Asp  Glu Thr Asp Leu Ser  Thr Tyr Gly Asp Ser  Leu Ser Gly 
    1115                 1120                 1125             


Trp Trp  Leu Leu Trp Lys Arg  Leu Asn Pro Trp Ala  Asp Lys Val 
    1130                 1135                 1140             


Lys Val  Pro Asp Met Ala Glu  Ile Gln Ser Arg Leu  Ala Tyr Val 
    1145                 1150                 1155             


Ser Cys  Val Arg Gln Leu Glu  Val Val Lys Ser Ser  Ser Tyr Cys 
    1160                 1165                 1170             


Glu Tyr  Leu Arg Pro Pro Ile  Asp Cys Phe Lys Thr  Met Asp Phe 
    1175                 1180                 1185             


Gly Lys  Phe Asp Gln Ile Tyr  Asp Val Gly Tyr Gln  Tyr Gly Lys 
    1190                 1195                 1200             


Ala Val  Phe Gly Gly Trp Ser  Arg Gly Asn Val Ile  Glu Lys Met 
    1205                 1210                 1215             


Leu Thr  Asp Arg Arg Ser Thr  Asp Leu Asn Glu Ser  Arg Arg Ala 
    1220                 1225                 1230             


Asp Val  Leu Ala Phe Pro Ser  Ser Gly Phe Thr Asp  Leu Ala Glu 
    1235                 1240                 1245             


Ile Val  Ser Arg Ile Glu Pro  Pro Thr Ser Tyr Val  Ser Asp Gly 
    1250                 1255                 1260             


Cys Ala  Asp Gly Glu Glu Ser  Asp Cys Leu Thr Glu  Tyr Glu Glu 
    1265                 1270                 1275             


Asp Ala  Gly Pro Asp Cys Ser  Arg Asp Glu Gly Gly  Ser Pro Glu 
    1280                 1285                 1290             


Gly Ala  Ser Pro Ser Thr Ala  Ser Glu Met Glu Glu  Glu Lys Ser 
    1295                 1300                 1305             


Ile Leu  Arg Gln Arg Arg Cys  Leu Pro Gln Glu Pro  Pro Gly Ser 
    1310                 1315                 1320             


Ala Thr  Asp Ala 
    1325         


<210>  3552
<211>  788
<212>  PRT
<213>  Homo sapiens

<400>  3552

Met Thr Ile His Gln Phe Leu Leu Leu Phe Leu Phe Trp Val Cys Leu 
1               5                   10                  15      


Pro His Phe Cys Ser Pro Glu Ile Met Phe Arg Arg Thr Pro Val Pro 
            20                  25                  30          


Gln Gln Arg Ile Leu Ser Ser Arg Val Pro Arg Ser Asp Gly Lys Ile 
        35                  40                  45              


Leu His Arg Gln Lys Arg Gly Trp Met Trp Asn Gln Phe Phe Leu Leu 
    50                  55                  60                  


Glu Glu Tyr Thr Gly Ser Asp Tyr Gln Tyr Val Gly Lys Leu His Ser 
65                  70                  75                  80  


Asp Gln Asp Lys Gly Asp Gly Ser Leu Lys Tyr Ile Leu Ser Gly Asp 
                85                  90                  95      


Gly Ala Gly Thr Leu Phe Ile Ile Asp Glu Lys Thr Gly Asp Ile His 
            100                 105                 110         


Ala Thr Arg Arg Ile Asp Arg Glu Glu Lys Ala Phe Tyr Thr Leu Arg 
        115                 120                 125             


Ala Gln Ala Ile Asn Arg Arg Thr Leu Arg Pro Val Glu Pro Glu Ser 
    130                 135                 140                 


Glu Phe Val Ile Lys Ile His Asp Ile Asn Asp Asn Glu Pro Thr Phe 
145                 150                 155                 160 


Pro Glu Glu Ile Tyr Thr Ala Ser Val Pro Glu Met Ser Val Val Gly 
                165                 170                 175     


Thr Ser Val Val Gln Val Thr Ala Thr Asp Ala Asp Asp Pro Ser Tyr 
            180                 185                 190         


Gly Asn Ser Ala Arg Val Ile Tyr Ser Ile Leu Gln Gly Gln Pro Tyr 
        195                 200                 205             


Phe Ser Val Glu Pro Glu Thr Gly Ile Ile Arg Thr Ala Leu Pro Asn 
    210                 215                 220                 


Met Asn Arg Glu Asn Arg Glu Gln Tyr Gln Val Val Ile Gln Ala Lys 
225                 230                 235                 240 


Asp Met Gly Gly Gln Met Gly Gly Leu Ser Gly Thr Thr Thr Val Asn 
                245                 250                 255     


Ile Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Arg Phe Pro Gln Asn 
            260                 265                 270         


Thr Ile His Leu Arg Val Leu Glu Ser Ser Pro Val Gly Thr Ala Ile 
        275                 280                 285             


Gly Ser Val Lys Ala Thr Asp Ala Asp Thr Gly Lys Asn Ala Glu Val 
    290                 295                 300                 


Glu Tyr Arg Ile Ile Asp Gly Asp Gly Thr Asp Met Phe Asp Ile Val 
305                 310                 315                 320 


Thr Glu Lys Asp Thr Gln Glu Gly Ile Ile Thr Val Lys Lys Pro Leu 
                325                 330                 335     


Asp Tyr Glu Ser Arg Arg Leu Tyr Thr Leu Lys Val Glu Ala Glu Asn 
            340                 345                 350         


Thr His Val Asp Pro Arg Phe Tyr Tyr Leu Gly Pro Phe Lys Asp Thr 
        355                 360                 365             


Thr Ile Val Lys Ile Ser Ile Glu Asp Val Asp Glu Pro Pro Val Phe 
    370                 375                 380                 


Ser Arg Ser Ser Tyr Leu Phe Glu Val His Glu Asp Ile Glu Val Gly 
385                 390                 395                 400 


Thr Ile Ile Gly Thr Val Met Ala Arg Asp Pro Asp Ser Ile Ser Ser 
                405                 410                 415     


Pro Ile Arg Phe Ser Leu Asp Arg His Thr Asp Leu Asp Arg Ile Phe 
            420                 425                 430         


Asn Ile His Ser Gly Asn Gly Ser Leu Tyr Thr Ser Lys Pro Leu Asp 
        435                 440                 445             


Arg Glu Leu Ser Gln Trp His Asn Leu Thr Val Ile Ala Ala Glu Ile 
    450                 455                 460                 


Asn Asn Pro Lys Glu Thr Thr Arg Val Ala Val Phe Val Arg Ile Leu 
465                 470                 475                 480 


Asp Val Asn Asp Asn Ala Pro Gln Phe Ala Val Phe Tyr Asp Thr Phe 
                485                 490                 495     


Val Cys Glu Asn Ala Arg Pro Gly Gln Leu Ile Gln Thr Ile Ser Ala 
            500                 505                 510         


Val Asp Lys Asp Asp Pro Leu Gly Gly Gln Lys Phe Phe Phe Ser Leu 
        515                 520                 525             


Ala Ala Val Asn Pro Asn Phe Thr Val Gln Asp Asn Glu Asp Asn Thr 
    530                 535                 540                 


Ala Arg Ile Leu Thr Arg Lys Asn Gly Phe Asn Arg His Glu Ile Ser 
545                 550                 555                 560 


Thr Tyr Leu Leu Pro Val Val Ile Ser Asp Asn Asp Tyr Pro Ile Gln 
                565                 570                 575     


Ser Ser Thr Gly Thr Leu Thr Ile Arg Val Cys Ala Cys Asp Ser Gln 
            580                 585                 590         


Gly Asn Met Gln Ser Cys Ser Ala Glu Ala Leu Leu Leu Pro Ala Gly 
        595                 600                 605             


Leu Ser Thr Gly Ala Leu Ile Ala Ile Leu Leu Cys Ile Ile Ile Leu 
    610                 615                 620                 


Leu Val Ile Val Val Leu Phe Ala Ala Leu Lys Arg Gln Arg Lys Lys 
625                 630                 635                 640 


Glu Pro Leu Ile Leu Ser Lys Glu Asp Ile Arg Asp Asn Ile Val Ser 
                645                 650                 655     


Tyr Asn Asp Glu Gly Gly Gly Glu Glu Asp Thr Gln Ala Phe Asp Ile 
            660                 665                 670         


Gly Thr Leu Arg Asn Pro Ala Ala Ile Glu Glu Lys Lys Leu Arg Arg 
        675                 680                 685             


Asp Ile Ile Pro Glu Thr Leu Phe Ile Pro Arg Arg Thr Pro Thr Ala 
    690                 695                 700                 


Pro Asp Asn Thr Asp Val Arg Asp Phe Ile Asn Glu Arg Leu Lys Glu 
705                 710                 715                 720 


His Asp Leu Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Ala Thr Tyr 
                725                 730                 735     


Ala Tyr Glu Gly Asn Asp Ser Ile Ala Glu Ser Leu Ser Ser Leu Glu 
            740                 745                 750         


Ser Gly Thr Thr Glu Gly Asp Gln Asn Tyr Asp Tyr Leu Arg Glu Trp 
        755                 760                 765             


Gly Pro Arg Phe Asn Lys Leu Ala Glu Met Tyr Gly Gly Gly Glu Ser 
    770                 775                 780                 


Asp Lys Asp Ser 
785             


<210>  3553
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  3553

Met Ser Arg Ile Asn Lys Asn Val Val Leu Ala Leu Leu Thr Leu Thr 
1               5                   10                  15      


Ser Ser Ala Phe Leu Leu Phe Gln Leu Tyr Tyr Tyr Lys His Tyr Leu 
            20                  25                  30          


Ser Thr Lys Asn Gly Ala Gly Leu Ser Lys Ser Lys Gly Ser Arg Ile 
        35                  40                  45              


Gly Phe Asp Ser Thr Gln Trp Arg Ala Val Lys Lys Phe Ile Met Leu 
    50                  55                  60                  


Thr Ser Asn Gln Asn Val Pro Val Phe Leu Ile Asp Pro Leu Ile Leu 
65                  70                  75                  80  


Glu Leu Ile Asn Lys Asn Phe Glu Gln Val Lys Asn Thr Ser His Gly 
                85                  90                  95      


Ser Thr Ser Gln Cys Lys Phe Phe Cys Val Pro Arg Asp Phe Thr Ala 
            100                 105                 110         


Phe Ala Leu Gln Tyr His Leu Trp Lys Asn Glu Glu Gly Trp Phe Arg 
        115                 120                 125             


Ile Ala Glu Asn Met Gly Phe Gln Cys Leu Lys Ile Glu Ser Lys Asp 
    130                 135                 140                 


Pro Arg Leu Asp Gly Ile Asp Ser Leu Ser Gly Thr Glu Ile Pro Leu 
145                 150                 155                 160 


His Tyr Ile Cys Lys Leu Ala Thr His Ala Ile His Leu Val Val Phe 
                165                 170                 175     


His Glu Arg Ser Gly Asn Tyr Leu Trp His Gly His Leu Arg Leu Lys 
            180                 185                 190         


Glu His Ile Asp Arg Lys Phe Val Pro Phe Arg Lys Leu Gln Phe Gly 
        195                 200                 205             


Arg Tyr Pro Gly Ala Phe Asp Arg Pro Glu Leu Gln Gln Val Thr Val 
    210                 215                 220                 


Asp Gly Leu Glu Val Leu Ile Pro Lys Asp Pro Met His Phe Val Glu 
225                 230                 235                 240 


Glu Val Pro His Ser Arg Phe Ile Glu Cys Arg Tyr Lys Glu Ala Arg 
                245                 250                 255     


Ala Phe Phe Gln Gln Tyr Leu Asp Asp Asn Thr Val Glu Ala Val Ala 
            260                 265                 270         


Phe Arg Lys Ser Ala Lys Glu Leu Leu Gln Leu Ala Ala Lys Thr Leu 
        275                 280                 285             


Asn Lys Leu Gly Val Pro Phe Trp Leu Ser Ser Gly Thr Cys Leu Gly 
    290                 295                 300                 


Trp Tyr Arg Gln Cys Asn Ile Ile Pro Tyr Ser Lys Asp Val Asp Leu 
305                 310                 315                 320 


Gly Ile Phe Ile Gln Asp Tyr Lys Ser Asp Ile Ile Leu Ala Phe Gln 
                325                 330                 335     


Asp Ala Gly Leu Pro Leu Lys His Lys Phe Gly Lys Val Glu Asp Ser 
            340                 345                 350         


Leu Glu Leu Ser Phe Gln Gly Lys Asp Asp Val Lys Leu Asp Val Phe 
        355                 360                 365             


Phe Phe Tyr Glu Glu Thr Asp His Met Trp Asn Gly Gly Thr Gln Ala 
    370                 375                 380                 


Lys Thr Gly Lys Lys Phe Lys Tyr Leu Phe Pro Lys Phe Thr Leu Cys 
385                 390                 395                 400 


Trp Thr Glu Phe Val Asp Met Lys Val His Val Pro Cys Glu Thr Leu 
                405                 410                 415     


Glu Tyr Ile Glu Ala Asn Tyr Gly Lys Thr Trp Lys Ile Pro Val Lys 
            420                 425                 430         


Thr Trp Asp Trp Lys Arg Ser Pro Pro Asn Val Gln Pro Asn Gly Ile 
        435                 440                 445             


Trp Pro Ile Ser Glu Trp Asp Glu Val Ile Gln Leu Tyr 
    450                 455                 460     


<210>  3554
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  3554

Met Ser Leu Thr Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro Leu Met Gly Gly Gln Asp Lys Pro Phe Leu Ser 
            20                  25                  30          


Ala Arg Pro Ser Thr Val Val Pro Arg Gly Gly His Val Ala Leu Gln 
        35                  40                  45              


Cys His Tyr Arg Arg Gly Phe Asn Asn Phe Met Leu Tyr Lys Glu Asp 
    50                  55                  60                  


Arg Ser His Val Pro Ile Phe His Gly Arg Ile Phe Gln Glu Ser Phe 
65                  70                  75                  80  


Ile Met Gly Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg Cys Arg 
                85                  90                  95      


Gly Ser Arg Pro His Ser Leu Thr Gly Trp Ser Ala Pro Ser Asn Pro 
            100                 105                 110         


Leu Val Ile Met Val Thr Gly Asn His Arg Lys Pro Ser Leu Leu Ala 
        115                 120                 125             


His Pro Gly Pro Leu Leu Lys Ser Gly Glu Thr Val Ile Leu Gln Cys 
    130                 135                 140                 


Trp Ser Asp Val Met Phe Glu His Phe Phe Leu His Arg Glu Gly Ile 
145                 150                 155                 160 


Ser Glu Asp Pro Ser Arg Leu Val Gly Gln Ile His Asp Gly Val Ser 
                165                 170                 175     


Lys Ala Asn Phe Ser Ile Gly Pro Leu Met Pro Val Leu Ala Gly Thr 
            180                 185                 190         


Tyr Arg Cys Tyr Gly Ser Val Pro His Ser Pro Tyr Gln Leu Ser Ala 
        195                 200                 205             


Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys Pro 
    210                 215                 220                 


Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Gln Ala Gly Glu Asn Val 
225                 230                 235                 240 


Thr Leu Ser Cys Ser Ser Trp Ser Ser Tyr Asp Ile Tyr His Leu Ser 
                245                 250                 255     


Arg Glu Gly Glu Ala His Glu Arg Arg Leu Arg Ala Val Pro Lys Val 
            260                 265                 270         


Asn Arg Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly 
        275                 280                 285             


Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Ala Leu Pro Cys Val Trp 
    290                 295                 300                 


Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser 
305                 310                 315                 320 


Ser Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Ser Gly Ile Cys 
                325                 330                 335     


Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Ile Phe Leu Phe 
            340                 345                 350         


Ile Leu Leu Leu Phe Phe Leu Leu Tyr Arg Trp Cys Ser Asn Lys Lys 
        355                 360                 365             


Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asp Arg Thr Val Asn 
    370                 375                 380                 


Arg Gln Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln 
385                 390                 395                 400 


Leu Asp His Cys Val Phe Ile Gln Arg Lys Ile Ser Arg Pro Ser Gln 
                405                 410                 415     


Arg Pro Lys Thr Pro Leu Thr Asp Thr Ser Val Tyr Thr Glu Leu Pro 
            420                 425                 430         


Asn Ala Glu Pro Arg Ser Lys Val Val Ser Cys Pro Arg Ala Pro Gln 
        435                 440                 445             


Ser Gly Leu Glu Gly Val Phe 
    450                 455 


<210>  3555
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  3555

Met Ser Ser Glu Glu Gly Lys Leu Phe Val Gly Gly Leu Asn Phe Asn 
1               5                   10                  15      


Thr Asp Glu Gln Ala Leu Glu Asp His Phe Ser Ser Phe Gly Pro Ile 
            20                  25                  30          


Ser Glu Val Val Val Val Lys Asp Arg Glu Thr Gln Arg Ser Arg Gly 
        35                  40                  45              


Phe Gly Phe Ile Thr Phe Thr Asn Pro Glu His Ala Ser Val Ala Met 
    50                  55                  60                  


Arg Ala Met Asn Gly Glu Ser Leu Asp Gly Arg Gln Ile Arg Val Asp 
65                  70                  75                  80  


His Ala Gly Lys Ser Ala Arg Gly Thr Arg Gly Gly Gly Phe Gly Ala 
                85                  90                  95      


His Gly Arg Gly Arg Ser Tyr Ser Arg Gly Gly Gly Asp Gln Gly Tyr 
            100                 105                 110         


Gly Ser Gly Arg Tyr Tyr Asp Ser Arg Pro Gly Gly Tyr Gly Tyr Gly 
        115                 120                 125             


Tyr Gly Arg Ser Arg Asp Tyr Asn Gly Arg Asn Gln Gly Gly Tyr Asp 
    130                 135                 140                 


Arg Tyr Ser Gly Gly Asn Tyr Arg Asp Asn Tyr Asp Asn 
145                 150                 155         


<210>  3556
<211>  652
<212>  PRT
<213>  Homo sapiens

<400>  3556

Met Ala Met Asp Glu Tyr Leu Trp Met Val Ile Leu Gly Phe Ile Ile 
1               5                   10                  15      


Ala Phe Ile Leu Ala Phe Ser Val Gly Ala Asn Asp Val Ala Asn Ser 
            20                  25                  30          


Phe Gly Thr Ala Val Gly Ser Gly Val Val Thr Leu Arg Gln Ala Cys 
        35                  40                  45              


Ile Leu Ala Ser Ile Phe Glu Thr Thr Gly Ser Val Leu Leu Gly Ala 
    50                  55                  60                  


Lys Val Gly Glu Thr Ile Arg Lys Gly Ile Ile Asp Val Asn Leu Tyr 
65                  70                  75                  80  


Asn Glu Thr Val Glu Thr Leu Met Ala Gly Glu Val Ser Ala Met Val 
                85                  90                  95      


Gly Ser Ala Val Trp Gln Leu Ile Ala Ser Phe Leu Arg Leu Pro Ile 
            100                 105                 110         


Ser Gly Thr His Cys Ile Val Gly Ser Thr Ile Gly Phe Ser Leu Val 
        115                 120                 125             


Ala Ile Gly Thr Lys Gly Val Gln Trp Met Glu Leu Val Lys Ile Val 
    130                 135                 140                 


Ala Ser Trp Phe Ile Ser Pro Leu Leu Ser Gly Phe Met Ser Gly Leu 
145                 150                 155                 160 


Leu Phe Val Leu Ile Arg Ile Phe Ile Leu Lys Lys Glu Asp Pro Val 
                165                 170                 175     


Pro Asn Gly Leu Arg Ala Leu Pro Val Phe Tyr Ala Ala Thr Ile Ala 
            180                 185                 190         


Ile Asn Val Phe Ser Ile Met Tyr Thr Gly Ala Pro Val Leu Gly Leu 
        195                 200                 205             


Val Leu Pro Met Trp Ala Ile Ala Leu Ile Ser Phe Gly Val Ala Leu 
    210                 215                 220                 


Leu Phe Ala Phe Phe Val Trp Leu Phe Val Cys Pro Trp Met Arg Arg 
225                 230                 235                 240 


Lys Ile Thr Gly Lys Leu Gln Lys Glu Gly Ala Leu Ser Arg Val Ser 
                245                 250                 255     


Asp Glu Ser Leu Ser Lys Val Gln Glu Ala Glu Ser Pro Val Phe Lys 
            260                 265                 270         


Glu Leu Pro Gly Ala Lys Ala Asn Asp Asp Ser Thr Ile Pro Leu Thr 
        275                 280                 285             


Gly Ala Ala Gly Glu Thr Leu Gly Thr Ser Glu Gly Thr Ser Ala Gly 
    290                 295                 300                 


Ser His Pro Arg Ala Ala Tyr Gly Arg Ala Leu Ser Met Thr His Gly 
305                 310                 315                 320 


Ser Val Lys Ser Pro Ile Ser Asn Gly Thr Phe Gly Phe Asp Gly His 
                325                 330                 335     


Thr Arg Ser Asp Gly His Val Tyr His Thr Val His Lys Asp Ser Gly 
            340                 345                 350         


Leu Tyr Lys Asp Leu Leu His Lys Ile His Ile Asp Arg Gly Pro Glu 
        355                 360                 365             


Glu Lys Pro Ala Gln Glu Ser Asn Tyr Arg Leu Leu Arg Arg Asn Asn 
    370                 375                 380                 


Ser Tyr Thr Cys Tyr Thr Ala Ala Ile Cys Gly Leu Pro Val His Ala 
385                 390                 395                 400 


Thr Phe Arg Ala Ala Asp Ser Ser Ala Pro Glu Asp Ser Glu Lys Leu 
                405                 410                 415     


Val Gly Asp Thr Val Ser Tyr Ser Lys Lys Arg Leu Arg Tyr Asp Ser 
            420                 425                 430         


Tyr Ser Ser Tyr Cys Asn Ala Val Ala Glu Ala Glu Ile Glu Ala Glu 
        435                 440                 445             


Glu Gly Gly Val Glu Met Lys Leu Ala Ser Glu Leu Ala Asp Pro Asp 
    450                 455                 460                 


Gln Pro Arg Glu Asp Pro Ala Glu Glu Glu Lys Glu Glu Lys Asp Ala 
465                 470                 475                 480 


Pro Glu Val His Leu Leu Phe His Phe Leu Gln Val Leu Thr Ala Cys 
                485                 490                 495     


Phe Gly Ser Phe Ala His Gly Gly Asn Asp Val Ser Asn Ala Ile Gly 
            500                 505                 510         


Pro Leu Val Ala Leu Trp Leu Ile Tyr Lys Gln Gly Gly Val Thr Gln 
        515                 520                 525             


Glu Ala Ala Thr Pro Val Trp Leu Leu Phe Tyr Gly Gly Val Gly Ile 
    530                 535                 540                 


Cys Thr Gly Leu Trp Val Trp Gly Arg Arg Val Ile Gln Thr Met Gly 
545                 550                 555                 560 


Lys Asp Leu Thr Pro Ile Thr Pro Ser Ser Gly Phe Thr Ile Glu Leu 
                565                 570                 575     


Ala Ser Ala Phe Thr Val Val Ile Ala Ser Asn Ile Gly Leu Pro Val 
            580                 585                 590         


Ser Thr Thr His Cys Lys Val Gly Ser Val Val Ala Val Gly Trp Ile 
        595                 600                 605             


Arg Ser Arg Lys Ala Val Asp Trp Arg Leu Phe Arg Asn Ile Phe Val 
    610                 615                 620                 


Ala Trp Phe Val Thr Val Pro Val Ala Gly Leu Phe Ser Ala Ala Val 
625                 630                 635                 640 


Met Ala Leu Leu Met Tyr Gly Ile Leu Pro Tyr Val 
                645                 650         


<210>  3557
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  3557

Met Ala Pro Asn Ile Tyr Leu Val Arg Gln Arg Ile Ser Arg Leu Gly 
1               5                   10                  15      


Gln Arg Met Ser Gly Phe Gln Ile Asn Leu Asn Pro Leu Lys Glu Pro 
            20                  25                  30          


Leu Gly Phe Ile Lys Val Leu Glu Trp Ile Ala Ser Ile Phe Ala Phe 
        35                  40                  45              


Ala Thr Cys Gly Gly Phe Lys Gly Gln Thr Glu Ile Gln Val Asn Cys 
    50                  55                  60                  


Pro Pro Ala Val Thr Glu Asn Lys Thr Val Thr Ala Thr Phe Gly Tyr 
65                  70                  75                  80  


Pro Phe Arg Leu Asn Glu Ala Ser Phe Gln Pro Pro Pro Gly Val Asn 
                85                  90                  95      


Ile Cys Asp Val Asn Trp Lys Asp Tyr Val Leu Ile Gly Asp Tyr Ser 
            100                 105                 110         


Ser Ser Ala Gln Phe Tyr Val Thr Phe Ala Val Phe Val Phe Leu Tyr 
        115                 120                 125             


Cys Ile Ala Ala Leu Leu Leu Tyr Val Gly Tyr Thr Ser Leu Tyr Leu 
    130                 135                 140                 


Asp Ser Arg Lys Leu Pro Met Ile Asp Phe Val Val Thr Leu Val Ala 
145                 150                 155                 160 


Thr Phe Leu Trp Leu Val Ser Thr Ser Ala Trp Ala Lys Ala Leu Thr 
                165                 170                 175     


Asp Ile Lys Ile Ala Thr Gly His Asn Ile Ile Asp Glu Leu Pro Pro 
            180                 185                 190         


Cys Lys Lys Lys Ala Val Leu Cys Tyr Phe Gly Ser Val Thr Ser Met 
        195                 200                 205             


Gly Ser Leu Asn Val Ser Val Ile Phe Gly Phe Leu Asn Met Ile Leu 
    210                 215                 220                 


Trp Gly Gly Asn Ala Trp Phe Val Tyr Lys Glu Thr Ser Leu His Ser 
225                 230                 235                 240 


Pro Ser Asn Thr Ser Ala Pro His Ser Gln Gly Gly Ile Pro Pro Pro 
                245                 250                 255     


Thr Gly Ile 
            


<210>  3558
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  3558

Met Asp Pro Arg Leu Ser Thr Val Arg Gln Thr Cys Cys Cys Phe Asn 
1               5                   10                  15      


Val Arg Ile Ala Thr Thr Ala Leu Ala Ile Tyr His Val Ile Met Ser 
            20                  25                  30          


Val Leu Leu Phe Ile Glu His Ser Val Glu Val Ala His Gly Lys Ala 
        35                  40                  45              


Ser Cys Lys Leu Ser Gln Met Gly Tyr Leu Arg Ile Ala Asp Leu Ile 
    50                  55                  60                  


Ser Ser Phe Leu Leu Ile Thr Met Leu Phe Ile Ile Ser Leu Ser Leu 
65                  70                  75                  80  


Leu Ile Gly Val Val Lys Asn Arg Glu Lys Tyr Leu Leu Pro Phe Leu 
                85                  90                  95      


Ser Leu Gln Ile Met Asp Tyr Leu Leu Cys Leu Leu Thr Leu Leu Gly 
            100                 105                 110         


Ser Tyr Ile Glu Leu Pro Ala Tyr Leu Lys Leu Ala Ser Arg Ser Arg 
        115                 120                 125             


Ala Ser Ser Ser Lys Phe Pro Leu Met Thr Leu Gln Leu Leu Asp Phe 
    130                 135                 140                 


Cys Leu Ser Ile Leu Thr Leu Cys Ser Ser Tyr Met Glu Val Pro Thr 
145                 150                 155                 160 


Tyr Leu Asn Phe Lys Ser Met Asn His Met Asn Tyr Leu Pro Ser Gln 
                165                 170                 175     


Glu Asp Met Pro His Asn Gln Phe Ile Lys Met Met Ile Ile Phe Ser 
            180                 185                 190         


Ile Ala Phe Ile Thr Val Leu Ile Phe Lys Val Tyr Met Phe Lys Cys 
        195                 200                 205             


Val Trp Arg Cys Tyr Arg Leu Ile Lys Cys Met Asn Ser Val Glu Glu 
    210                 215                 220                 


Lys Arg Asn Ser Lys Met Leu Gln Lys Val Val Leu Pro Ser Tyr Glu 
225                 230                 235                 240 


Glu Ala Leu Ser Leu Pro Ser Lys Thr Pro Glu Gly Gly Pro Ala Pro 
                245                 250                 255     


Pro Pro Tyr Ser Glu Val 
            260         


<210>  3559
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  3559

Met Gly Ala Arg Gly Ala Pro Ser Arg Arg Arg Gln Ala Gly Arg Arg 
1               5                   10                  15      


Leu Arg Tyr Leu Pro Thr Gly Ser Phe Pro Phe Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Cys Ile Gln Leu Gly Gly Gly Gln Lys Lys Lys Glu Asn Leu 
        35                  40                  45              


Leu Ala Glu Lys Val Glu Gln Leu Met Glu Trp Ser Ser Arg Arg Ser 
    50                  55                  60                  


Ile Phe Arg Met Asn Gly Asp Lys Phe Arg Lys Phe Ile Lys Ala Pro 
65                  70                  75                  80  


Pro Arg Asn Tyr Ser Met Ile Val Met Phe Thr Ala Leu Gln Pro Gln 
                85                  90                  95      


Arg Gln Cys Ser Val Cys Arg Gln Ala Asn Glu Glu Tyr Gln Ile Leu 
            100                 105                 110         


Ala Asn Ser Trp Arg Tyr Ser Ser Ala Phe Cys Asn Lys Leu Phe Phe 
        115                 120                 125             


Ser Met Val Asp Tyr Asp Glu Gly Thr Asp Val Phe Gln Gln Leu Asn 
    130                 135                 140                 


Met Asn Ser Ala Pro Thr Phe Met His Phe Pro Pro Lys Gly Arg Pro 
145                 150                 155                 160 


Lys Arg Ala Asp Thr Phe Asp Leu Gln Arg Ile Gly Phe Ala Ala Glu 
                165                 170                 175     


Gln Leu Ala Lys Trp Ile Ala Asp Arg Thr Asp Val His Ile Arg Val 
            180                 185                 190         


Phe Arg Pro Pro Asn Tyr Ser Gly Thr Ile Ala Leu Ala Leu Leu Val 
        195                 200                 205             


Ser Leu Val Gly Gly Leu Leu Tyr Leu Arg Arg Asn Asn Leu Glu Phe 
    210                 215                 220                 


Ile Tyr Asn Lys Thr Gly Trp Ala Met Val Ser Leu Cys Ile Val Phe 
225                 230                 235                 240 


Ala Met Thr Ser Gly Gln Met Trp Asn His Ile Arg Gly Pro Pro Tyr 
                245                 250                 255     


Ala His Lys Asn Pro His Asn Gly Gln Val Ser Tyr Ile His Gly Ser 
            260                 265                 270         


Ser Gln Ala Gln Phe Val Ala Glu Ser His Ile Ile Leu Val Leu Asn 
        275                 280                 285             


Ala Ala Ile Thr Met Gly Met Val Leu Leu Asn Glu Ala Ala Thr Ser 
    290                 295                 300                 


Lys Gly Asp Val Gly Lys Arg Arg Ile Ile Cys Leu Val Gly Leu Gly 
305                 310                 315                 320 


Leu Val Val Phe Phe Phe Ser Phe Leu Leu Ser Ile Phe Arg Ser Lys 
                325                 330                 335     


Tyr His Gly Tyr Pro Tyr Ser Asp Leu Asp Phe Glu 
            340                 345             


<210>  3560
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  3560

Met Arg Asn Lys Lys Ile Leu Lys Glu Asp Glu Leu Leu Ser Glu Thr 
1               5                   10                  15      


Gln Gln Ala Ala Phe His Gln Ile Ala Met Glu Pro Phe Glu Ile Asn 
            20                  25                  30          


Val Pro Lys Pro Lys Arg Arg Asn Gly Val Asn Phe Ser Leu Ala Val 
        35                  40                  45              


Val Val Ile Tyr Leu Ile Leu Leu Thr Ala Gly Ala Gly Leu Leu Val 
    50                  55                  60                  


Val Gln Val Leu Asn Leu Gln Ala Arg Leu Arg Val Leu Glu Met Tyr 
65                  70                  75                  80  


Phe Leu Asn Asp Thr Leu Ala Ala Glu Asp Ser Pro Ser Phe Ser Leu 
                85                  90                  95      


Leu Gln Ser Ala His Pro Gly Glu His Leu Ala Gln Gly Ala Ser Arg 
            100                 105                 110         


Leu Gln Val Leu Gln Ala Gln Leu Thr Trp Val Arg Val Ser His Glu 
        115                 120                 125             


His Leu Leu Gln Arg Val Asp Asn Phe Thr Gln Asn Pro Gly Met Phe 
    130                 135                 140                 


Arg Ile Lys Gly Glu Gln Gly Ala Pro Gly Leu Gln Gly His Lys Gly 
145                 150                 155                 160 


Ala Met Gly Met Pro Gly Ala Pro Gly Pro Pro Gly Pro Pro Ala Glu 
                165                 170                 175     


Lys Gly Ala Lys Gly Ala Met Gly Arg Asp Gly Ala Thr Gly Pro Ser 
            180                 185                 190         


Gly Pro Gln Gly Pro Pro Gly Val Lys Gly Glu Ala Gly Leu Gln Gly 
        195                 200                 205             


Pro Gln Gly Ala Pro Gly Lys Gln Gly Ala Thr Gly Thr Pro Gly Pro 
    210                 215                 220                 


Gln Gly Glu Lys Gly Ser Lys Gly Asp Gly Gly Leu Ile Gly Pro Lys 
225                 230                 235                 240 


Gly Glu Thr Gly Thr Lys Gly Glu Lys Gly Asp Leu Gly Leu Pro Gly 
                245                 250                 255     


Ser Lys Gly Asp Arg Gly Met Lys Gly Asp Ala Gly Val Met Gly Pro 
            260                 265                 270         


Pro Gly Ala Gln Gly Ser Lys Gly Asp Phe Gly Arg Pro Gly Pro Pro 
        275                 280                 285             


Gly Leu Ala Gly Phe Pro Gly Ala Lys Gly Asp Gln Gly Gln Pro Gly 
    290                 295                 300                 


Leu Gln Gly Val Pro Gly Pro Pro Gly Ala Val Gly His Pro Gly Ala 
305                 310                 315                 320 


Lys Gly Glu Pro Gly Ser Ala Gly Ser Pro Gly Arg Ala Gly Leu Pro 
                325                 330                 335     


Gly Ser Pro Gly Ser Pro Gly Ala Thr Gly Leu Lys Gly Ser Lys Gly 
            340                 345                 350         


Asp Thr Gly Leu Gln Gly Gln Gln Gly Arg Lys Gly Glu Ser Gly Val 
        355                 360                 365             


Pro Gly Pro Ala Gly Val Lys Gly Glu Gln Gly Ser Pro Gly Leu Ala 
    370                 375                 380                 


Gly Pro Lys Gly Ala Pro Gly Gln Ala Gly Gln Lys Gly Asp Gln Gly 
385                 390                 395                 400 


Val Lys Gly Ser Ser Gly Glu Gln Gly Val Lys Gly Glu Lys Gly Glu 
                405                 410                 415     


Arg Gly Glu Asn Ser Val Ser Val Arg Ile Val Gly Ser Ser Asn Arg 
            420                 425                 430         


Gly Arg Ala Glu Val Tyr Tyr Ser Gly Thr Trp Gly Thr Ile Cys Asp 
        435                 440                 445             


Asp Glu Trp Gln Asn Ser Asp Ala Ile Val Phe Cys Arg Met Leu Gly 
    450                 455                 460                 


Tyr Ser Lys Gly Arg Ala Leu Tyr Lys Val Gly Ala Gly Thr Gly Gln 
465                 470                 475                 480 


Ile Trp Leu Asp Asn Val Gln Cys Arg Gly Thr Glu Ser Thr Leu Trp 
                485                 490                 495     


Ser Cys Thr Lys Asn Ser Trp Gly His His Asp Cys Ser His Glu Glu 
            500                 505                 510         


Asp Ala Gly Val Glu Cys Ser Val 
        515                 520 


<210>  3561
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  3561

Met Thr Val Leu Glu Ile Thr Leu Ala Val Ile Leu Thr Leu Leu Gly 
1               5                   10                  15      


Leu Ala Ile Leu Ala Ile Leu Leu Thr Arg Trp Ala Arg Cys Lys Gln 
            20                  25                  30          


Ser Glu Met Tyr Ile Ser Arg Tyr Ser Ser Glu Gln Ser Ala Arg Leu 
        35                  40                  45              


Leu Asp Tyr Glu Asp Gly Arg Gly Ser Arg His Ala Tyr Ser Thr Gln 
    50                  55                  60                  


Ser Asp Thr Ser Tyr Asp Asn Arg Glu Arg Ser Lys Arg Asp Tyr Thr 
65                  70                  75                  80  


Pro Ser Thr Asn Ser Leu Val Ser Met Ala Ser Lys Phe Ser Leu Gly 
                85                  90                  95      


Gln Thr Glu Leu Ile Leu Leu Leu Met Cys Phe Ile Leu Ala Leu Ser 
            100                 105                 110         


Arg Ser Ser Ile Gly Ser Ile Lys Cys Leu Gln Thr Thr Glu Glu Pro 
        115                 120                 125             


Pro Ser Arg Thr Ala Gly Ala Met Met Gln Phe Thr Ala Pro Ile Pro 
    130                 135                 140                 


Gly Ala Thr Gly Pro Ile Lys Leu Ser Gln Lys Thr Ile Val Gln Thr 
145                 150                 155                 160 


Pro Gly Pro Ile Val Gln Tyr Pro Gly Ser Asn Ala Gly Pro Pro Ser 
                165                 170                 175     


Ala Pro Arg Gly Pro Pro Met Ala Pro Ile Ile Ile Ser Gln Arg Thr 
            180                 185                 190         


Ala Arg Ile Pro Gln Val His Thr Met Asp Ser Ser Gly Lys Ile Thr 
        195                 200                 205             


Leu Thr Pro Val Val Ile Leu Thr Gly Tyr Met Asp Glu Glu Leu Ala 
    210                 215                 220                 


Lys Lys Ser Cys Ser Lys Ile Gln Ile Leu Lys Cys Gly Gly Thr Ala 
225                 230                 235                 240 


Arg Ser Gln Asn Ser Arg Glu Glu Asn Lys Glu Ala Leu Lys Asn Asp 
                245                 250                 255     


Ile Ile Phe Thr Asn Ser Val Glu Ser Leu Lys Ser Ala His Ile Lys 
            260                 265                 270         


Glu Pro Glu Arg Glu Gly Lys Gly Thr Asp Leu Glu Lys Asp Lys Ile 
        275                 280                 285             


Gly Met Glu Val Lys Val Asp Ser Asp Ala Gly Ile Pro Lys Arg Gln 
    290                 295                 300                 


Glu Thr Gln Leu Lys Ile Ser Glu Met Ser Ile Pro Gln Gly Gln Gly 
305                 310                 315                 320 


Ala Gln Ile Lys Lys Ser Val Ser Asp Val Pro Arg Gly Gln Glu Ser 
                325                 330                 335     


Gln Val Lys Lys Ser Glu Ser Gly Val Pro Lys Gly Gln Glu Ala Gln 
            340                 345                 350         


Val Thr Lys Ser Gly Leu Val Val Leu Lys Gly Gln Glu Ala Gln Val 
        355                 360                 365             


Glu Lys Ser Glu Met Gly Val Pro Arg Arg Gln Glu Ser Gln Val Lys 
    370                 375                 380                 


Lys Ser Gln Ser Gly Val Ser Lys Gly Gln Glu Ala Gln Val Lys Lys 
385                 390                 395                 400 


Arg Glu Ser Val Val Leu Lys Gly Gln Glu Ala Gln Val Glu Lys Ser 
                405                 410                 415     


Glu Leu Lys Val Pro Lys Gly Gln Glu Gly Gln Val Glu Lys Thr Glu 
            420                 425                 430         


Ala Asp Val Pro Lys Glu Gln Glu Val Gln Glu Lys Lys Ser Glu Ala 
        435                 440                 445             


Gly Val Leu Lys Gly Pro Glu Ser Gln Val Lys Asn Thr Glu Val Ser 
    450                 455                 460                 


Val Pro Glu Thr Leu Glu Ser Gln Val Lys Lys Ser Glu Ser Gly Val 
465                 470                 475                 480 


Leu Lys Gly Gln Glu Ala Gln Glu Lys Lys Glu Ser Phe Glu Asp Lys 
                485                 490                 495     


Gly Asn Asn Asp Lys Glu Lys Glu Arg Asp Ala Glu Lys Asp Pro Asn 
            500                 505                 510         


Lys Lys Glu Lys Gly Asp Lys Asn Thr Lys Gly Asp Lys Gly Lys Asp 
        515                 520                 525             


Lys Val Lys Gly Lys Arg Glu Ser Glu Ile Asn Gly Glu Lys Ser Lys 
    530                 535                 540                 


Gly Ser Lys Arg Ala Lys Ala Asn Thr Gly Arg Lys Tyr Asn Lys Lys 
545                 550                 555                 560 


Val Glu Glu 
            


<210>  3562
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  3562

Met Gly Leu Cys Lys Cys Pro Lys Arg Lys Val Thr Asn Leu Phe Cys 
1               5                   10                  15      


Phe Glu His Arg Val Asn Val Cys Glu His Cys Leu Val Ala Asn His 
            20                  25                  30          


Ala Lys Cys Ile Val Gln Ser Tyr Leu Gln Trp Leu Gln Asp Ser Asp 
        35                  40                  45              


Tyr Asn Pro Asn Cys Arg Leu Cys Asn Ile Pro Leu Ala Ser Arg Glu 
    50                  55                  60                  


Thr Thr Arg Leu Val Cys Tyr Asp Leu Phe His Trp Ala Cys Leu Asn 
65                  70                  75                  80  


Glu Arg Ala Ala Gln Leu Pro Arg Asn Thr Ala Pro Ala Gly Tyr Gln 
                85                  90                  95      


Cys Pro Ser Cys Asn Gly Pro Ile Phe Pro Pro Thr Asn Leu Ala Gly 
            100                 105                 110         


Pro Val Ala Ser Ala Leu Arg Glu Lys Leu Ala Thr Val Asn Trp Ala 
        115                 120                 125             


Arg Ala Gly Leu Gly Leu Pro Leu Ile Asp Glu Val Val Ser Pro Glu 
    130                 135                 140                 


Pro Glu Pro Leu Asn Thr Ser Asp Phe Ser Asp Trp Ser Ser Phe Asn 
145                 150                 155                 160 


Ala Ser Ser Thr Pro Gly Pro Glu Glu Val Asp Ser Ala Ser Ala Ala 
                165                 170                 175     


Pro Ala Phe Tyr Ser Gln Ala Pro Arg Pro Pro Ala Ser Pro Gly Arg 
            180                 185                 190         


Pro Glu Gln His Thr Val Ile His Met Gly Asn Pro Glu Pro Leu Thr 
        195                 200                 205             


His Ala Pro Arg Lys Val Tyr Asp Thr Arg Asp Asp Asp Arg Thr Pro 
    210                 215                 220                 


Gly Leu His Gly Asp Cys Asp Asp Asp Lys Tyr Arg Arg Arg Pro Ala 
225                 230                 235                 240 


Leu Gly Trp Leu Ala Arg Leu Leu Arg Ser Arg Ala Gly Ser Arg Lys 
                245                 250                 255     


Arg Pro Leu Thr Leu Leu Gln Arg Ala Gly Leu Leu Leu Leu Leu Gly 
            260                 265                 270         


Leu Leu Gly Phe Leu Ala Leu Leu Ala Leu Met Ser Arg Leu Gly Arg 
        275                 280                 285             


Ala Ala Ala Asp Ser Asp Pro Asn Leu Asp Pro Leu Met Asn Pro His 
    290                 295                 300                 


Ile Arg Val Gly Pro Ser 
305                 310 


<210>  3563
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  3563

Met Asp Trp Gly Thr Leu His Thr Phe Ile Gly Gly Val Asn Lys His 
1               5                   10                  15      


Ser Thr Ser Ile Gly Lys Val Trp Ile Thr Val Ile Phe Ile Phe Arg 
            20                  25                  30          


Val Met Ile Leu Val Val Ala Ala Gln Glu Val Trp Gly Asp Glu Gln 
        35                  40                  45              


Glu Asp Phe Val Cys Asn Thr Leu Gln Pro Gly Cys Lys Asn Val Cys 
    50                  55                  60                  


Tyr Asp His Phe Phe Pro Val Ser His Ile Arg Leu Trp Ala Leu Gln 
65                  70                  75                  80  


Leu Ile Phe Val Ser Thr Pro Ala Leu Leu Val Ala Met His Val Ala 
                85                  90                  95      


Tyr Tyr Arg His Glu Thr Thr Arg Lys Phe Arg Arg Gly Glu Lys Arg 
            100                 105                 110         


Asn Asp Phe Lys Asp Ile Glu Asp Ile Lys Lys Gln Lys Val Arg Ile 
        115                 120                 125             


Glu Gly Ser Leu Trp Trp Thr Tyr Thr Ser Ser Ile Phe Phe Arg Ile 
    130                 135                 140                 


Ile Phe Glu Ala Ala Phe Met Tyr Val Phe Tyr Phe Leu Tyr Asn Gly 
145                 150                 155                 160 


Tyr His Leu Pro Trp Val Leu Lys Cys Gly Ile Asp Pro Cys Pro Asn 
                165                 170                 175     


Leu Val Asp Cys Phe Ile Ser Arg Pro Thr Glu Lys Thr Val Phe Thr 
            180                 185                 190         


Ile Phe Met Ile Ser Ala Ser Val Ile Cys Met Leu Leu Asn Val Ala 
        195                 200                 205             


Glu Leu Cys Tyr Leu Leu Leu Lys Val Cys Phe Arg Arg Ser Lys Arg 
    210                 215                 220                 


Ala Gln Thr Gln Lys Asn His Pro Asn His Ala Leu Lys Glu Ser Lys 
225                 230                 235                 240 


Gln Asn Glu Met Asn Glu Leu Ile Ser Asp Ser Gly Gln Asn Ala Ile 
                245                 250                 255     


Thr Gly Phe Pro Ser 
            260     


<210>  3564
<211>  540
<212>  PRT
<213>  Homo sapiens

<400>  3564

Met Asn Ser Thr Gly His Leu Gln Asp Ala Pro Asn Ala Thr Ser Leu 
1               5                   10                  15      


His Val Pro His Ser Gln Glu Gly Asn Ser Thr Ser Leu Gln Glu Gly 
            20                  25                  30          


Leu Gln Asp Leu Ile His Thr Ala Thr Leu Val Thr Cys Thr Phe Leu 
        35                  40                  45              


Leu Ala Val Ile Phe Cys Leu Gly Ser Tyr Gly Asn Phe Ile Val Phe 
    50                  55                  60                  


Leu Ser Phe Phe Asp Pro Ala Phe Arg Lys Phe Arg Thr Asn Phe Asp 
65                  70                  75                  80  


Phe Met Ile Leu Asn Leu Ser Phe Cys Asp Leu Phe Ile Cys Gly Val 
                85                  90                  95      


Thr Ala Pro Met Phe Thr Phe Val Leu Phe Phe Ser Ser Ala Ser Ser 
            100                 105                 110         


Ile Pro Asp Ala Phe Cys Phe Thr Phe His Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ile Ile Met Ser Leu Lys Thr Val Ala Val Ile Ala Leu His Arg Leu 
    130                 135                 140                 


Arg Met Val Leu Gly Lys Gln Pro Asn Arg Thr Ala Ser Phe Pro Cys 
145                 150                 155                 160 


Thr Val Leu Leu Thr Leu Leu Leu Trp Ala Thr Ser Phe Thr Leu Ala 
                165                 170                 175     


Thr Leu Ala Thr Leu Lys Thr Ser Lys Ser His Leu Cys Leu Pro Met 
            180                 185                 190         


Ser Ser Leu Ile Ala Gly Lys Gly Lys Ala Ile Leu Ser Leu Tyr Val 
        195                 200                 205             


Val Asp Phe Thr Phe Cys Val Ala Val Val Ser Val Ser Tyr Ile Met 
    210                 215                 220                 


Ile Ala Gln Thr Leu Arg Lys Asn Ala Gln Val Arg Lys Cys Pro Pro 
225                 230                 235                 240 


Val Ile Thr Val Asp Ala Ser Arg Pro Gln Pro Phe Met Gly Val Pro 
                245                 250                 255     


Val Gln Gly Gly Gly Asp Pro Ile Gln Cys Ala Met Pro Ala Leu Tyr 
            260                 265                 270         


Arg Asn Gln Asn Tyr Asn Lys Leu Gln His Val Gln Thr Arg Gly Tyr 
        275                 280                 285             


Thr Lys Ser Pro Asn Gln Leu Val Thr Pro Ala Ala Ser Arg Leu Gln 
    290                 295                 300                 


Leu Val Ser Ala Ile Asn Leu Ser Thr Ala Lys Asp Ser Lys Ala Val 
305                 310                 315                 320 


Val Thr Cys Val Ile Ile Val Leu Ser Val Leu Val Cys Cys Leu Pro 
                325                 330                 335     


Leu Gly Ile Ser Leu Val Gln Val Val Leu Ser Ser Asn Gly Ser Phe 
            340                 345                 350         


Ile Leu Tyr Gln Phe Glu Leu Phe Gly Phe Thr Leu Ile Phe Phe Lys 
        355                 360                 365             


Ser Gly Leu Asn Pro Phe Ile Tyr Ser Arg Asn Ser Ala Gly Leu Arg 
    370                 375                 380                 


Arg Lys Val Leu Trp Cys Leu Gln Tyr Ile Gly Leu Gly Phe Phe Cys 
385                 390                 395                 400 


Cys Lys Gln Lys Thr Arg Leu Arg Ala Met Gly Lys Gly Asn Leu Glu 
                405                 410                 415     


Val Asn Arg Asn Lys Ser Ser His His Glu Thr Asn Ser Ala Tyr Met 
            420                 425                 430         


Leu Ser Pro Lys Pro Gln Lys Lys Phe Val Asp Gln Ala Cys Gly Pro 
        435                 440                 445             


Ser His Ser Lys Glu Ser Met Val Ser Pro Lys Ile Ser Ala Gly His 
    450                 455                 460                 


Gln His Cys Gly Gln Ser Ser Ser Thr Pro Ile Asn Thr Arg Ile Glu 
465                 470                 475                 480 


Pro Tyr Tyr Ser Ile Tyr Asn Ser Ser Pro Ser Gln Glu Glu Ser Ser 
                485                 490                 495     


Pro Cys Asn Leu Gln Pro Val Asn Ser Phe Gly Phe Ala Asn Ser Tyr 
            500                 505                 510         


Ile Ala Met His Tyr His Thr Thr Asn Asp Leu Val Gln Glu Tyr Asp 
        515                 520                 525             


Ser Thr Ser Ala Lys Gln Ile Pro Val Pro Ser Val 
    530                 535                 540 


<210>  3565
<211>  797
<212>  PRT
<213>  Homo sapiens

<400>  3565

Met Ala His Arg Cys Leu Arg Leu Trp Gly Arg Gly Gly Cys Trp Pro 
1               5                   10                  15      


Arg Gly Leu Gln Gln Leu Leu Val Pro Gly Gly Val Gly Pro Gly Glu 
            20                  25                  30          


Gln Pro Cys Leu Arg Thr Leu Tyr Arg Phe Val Thr Thr Gln Ala Arg 
        35                  40                  45              


Ala Ser Arg Asn Ser Leu Leu Thr Asp Ile Ile Ala Ala Tyr Gln Arg 
    50                  55                  60                  


Phe Cys Ser Arg Pro Pro Lys Gly Phe Glu Lys Tyr Phe Pro Asn Gly 
65                  70                  75                  80  


Lys Asn Gly Lys Lys Ala Ser Glu Pro Lys Glu Val Met Gly Glu Lys 
                85                  90                  95      


Lys Glu Ser Lys Pro Ala Ala Thr Thr Arg Ser Ser Gly Gly Gly Gly 
            100                 105                 110         


Gly Gly Gly Gly Lys Arg Gly Gly Lys Lys Asp Asp Ser His Trp Trp 
        115                 120                 125             


Ser Arg Phe Gln Lys Gly Asp Ile Pro Trp Asp Asp Lys Asp Phe Arg 
    130                 135                 140                 


Met Phe Phe Leu Trp Thr Ala Leu Phe Trp Gly Gly Val Met Phe Tyr 
145                 150                 155                 160 


Leu Leu Leu Lys Arg Ser Gly Arg Glu Ile Thr Trp Lys Asp Phe Val 
                165                 170                 175     


Asn Asn Tyr Leu Ser Lys Gly Val Val Asp Arg Leu Glu Val Val Asn 
            180                 185                 190         


Lys Arg Phe Val Arg Val Thr Phe Thr Pro Gly Lys Thr Pro Val Asp 
        195                 200                 205             


Gly Gln Tyr Val Trp Phe Asn Ile Gly Ser Val Asp Thr Phe Glu Arg 
    210                 215                 220                 


Asn Leu Glu Thr Leu Gln Gln Glu Leu Gly Ile Glu Gly Glu Asn Arg 
225                 230                 235                 240 


Val Pro Val Val Tyr Ile Ala Glu Ser Asp Gly Ser Phe Leu Leu Ser 
                245                 250                 255     


Met Leu Pro Thr Val Leu Ile Ile Ala Phe Leu Leu Tyr Thr Ile Arg 
            260                 265                 270         


Arg Gly Pro Ala Gly Ile Gly Arg Thr Gly Arg Gly Met Gly Gly Leu 
        275                 280                 285             


Phe Ser Val Gly Glu Thr Thr Ala Lys Val Leu Lys Asp Glu Ile Asp 
    290                 295                 300                 


Val Lys Phe Lys Asp Val Ala Gly Cys Glu Glu Ala Lys Leu Glu Ile 
305                 310                 315                 320 


Met Glu Phe Val Asn Phe Leu Lys Asn Pro Lys Gln Tyr Gln Asp Leu 
                325                 330                 335     


Gly Ala Lys Ile Pro Lys Gly Ala Ile Leu Thr Gly Pro Pro Gly Thr 
            340                 345                 350         


Gly Lys Thr Leu Leu Ala Lys Ala Thr Ala Gly Glu Ala Asn Val Pro 
        355                 360                 365             


Phe Ile Thr Val Ser Gly Ser Glu Phe Leu Glu Met Phe Val Gly Val 
    370                 375                 380                 


Gly Pro Ala Arg Val Arg Asp Leu Phe Ala Leu Ala Arg Lys Asn Ala 
385                 390                 395                 400 


Pro Cys Ile Leu Phe Ile Asp Glu Ile Asp Ala Val Gly Arg Lys Arg 
                405                 410                 415     


Gly Arg Gly Asn Phe Gly Gly Gln Ser Glu Gln Glu Asn Thr Leu Asn 
            420                 425                 430         


Gln Leu Leu Val Glu Met Asp Gly Phe Asn Thr Thr Thr Asn Val Val 
        435                 440                 445             


Ile Leu Ala Gly Thr Asn Arg Pro Asp Ile Leu Asp Pro Ala Leu Leu 
    450                 455                 460                 


Arg Pro Gly Arg Phe Asp Arg Gln Ile Phe Ile Gly Pro Pro Asp Ile 
465                 470                 475                 480 


Lys Gly Arg Ala Ser Ile Phe Lys Val His Leu Arg Pro Leu Lys Leu 
                485                 490                 495     


Asp Ser Thr Leu Glu Lys Asp Lys Leu Ala Arg Lys Leu Ala Ser Leu 
            500                 505                 510         


Thr Pro Gly Phe Ser Gly Ala Asp Val Ala Asn Val Cys Asn Glu Ala 
        515                 520                 525             


Ala Leu Ile Ala Ala Arg His Leu Ser Asp Ser Ile Asn Gln Lys His 
    530                 535                 540                 


Phe Glu Gln Ala Ile Glu Arg Val Ile Gly Gly Leu Glu Lys Lys Thr 
545                 550                 555                 560 


Gln Val Leu Gln Pro Glu Glu Lys Lys Thr Val Ala Tyr His Glu Ala 
                565                 570                 575     


Gly His Ala Val Ala Gly Trp Tyr Leu Glu His Ala Asp Pro Leu Leu 
            580                 585                 590         


Lys Val Ser Ile Ile Pro Arg Gly Lys Gly Leu Gly Tyr Ala Gln Tyr 
        595                 600                 605             


Leu Pro Lys Glu Gln Tyr Leu Tyr Thr Lys Glu Gln Leu Leu Asp Arg 
    610                 615                 620                 


Met Cys Met Thr Leu Gly Gly Arg Val Ser Glu Glu Ile Phe Phe Gly 
625                 630                 635                 640 


Arg Ile Thr Thr Gly Ala Gln Asp Asp Leu Arg Lys Val Thr Gln Ser 
                645                 650                 655     


Ala Tyr Ala Gln Ile Val Gln Phe Gly Met Asn Glu Lys Val Gly Gln 
            660                 665                 670         


Ile Ser Phe Asp Leu Pro Arg Gln Gly Asp Met Val Leu Glu Lys Pro 
        675                 680                 685             


Tyr Ser Glu Ala Thr Ala Arg Leu Ile Asp Asp Glu Val Arg Ile Leu 
    690                 695                 700                 


Ile Asn Asp Ala Tyr Lys Arg Thr Val Ala Leu Leu Thr Glu Lys Lys 
705                 710                 715                 720 


Ala Asp Val Glu Lys Val Ala Leu Leu Leu Leu Glu Lys Glu Val Leu 
                725                 730                 735     


Asp Lys Asn Asp Met Val Glu Leu Leu Gly Pro Arg Pro Phe Ala Glu 
            740                 745                 750         


Lys Ser Thr Tyr Glu Glu Phe Val Glu Gly Thr Gly Ser Leu Asp Glu 
        755                 760                 765             


Asp Thr Ser Leu Pro Glu Gly Leu Lys Asp Trp Asn Lys Glu Arg Glu 
    770                 775                 780                 


Lys Glu Lys Glu Glu Pro Pro Gly Glu Lys Val Ala Asn 
785                 790                 795         


<210>  3566
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  3566

Met Asn Leu Phe Arg Phe Leu Gly Asp Leu Ser His Leu Leu Ala Ile 
1               5                   10                  15      


Ile Leu Leu Leu Leu Lys Ile Trp Lys Ser Arg Ser Cys Ala Gly Ile 
            20                  25                  30          


Ser Gly Lys Ser Gln Val Leu Phe Ala Val Val Phe Thr Ala Arg Tyr 
        35                  40                  45              


Leu Asp Leu Phe Thr Asn Tyr Ile Ser Leu Tyr Asn Thr Cys Met Lys 
    50                  55                  60                  


Val Val Tyr Ile Ala Cys Ser Phe Thr Thr Val Trp Leu Ile Tyr Ser 
65                  70                  75                  80  


Lys Phe Lys Ala Thr Tyr Asp Gly Asn His Asp Thr Phe Arg Val Glu 
                85                  90                  95      


Phe Leu Val Val Pro Thr Ala Ile Leu Ala Phe Leu Val Asn His Asp 
            100                 105                 110         


Phe Thr Pro Leu Glu Ile Leu Trp Thr Phe Ser Ile Tyr Leu Glu Ser 
        115                 120                 125             


Val Ala Ile Leu Pro Gln Leu Phe Met Val Ser Lys Thr Gly Glu Ala 
    130                 135                 140                 


Glu Thr Ile Thr Ser His Tyr Leu Phe Ala Leu Gly Val Tyr Arg Thr 
145                 150                 155                 160 


Leu Tyr Leu Phe Asn Trp Ile Trp Arg Tyr His Phe Glu Gly Phe Phe 
                165                 170                 175     


Asp Leu Ile Ala Ile Val Ala Gly Leu Val Gln Thr Val Leu Tyr Cys 
            180                 185                 190         


Asp Phe Phe Tyr Leu Tyr Ile Thr Lys Val Leu Lys Gly Lys Lys Leu 
        195                 200                 205             


Ser Leu Pro Ala 
    210         


<210>  3567
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  3567

Met Ser Lys Leu Pro Arg Glu Leu Thr Arg Asp Leu Glu Arg Ser Leu 
1               5                   10                  15      


Pro Ala Val Ala Ser Leu Gly Ser Ser Leu Ser His Ser Gln Ser Leu 
            20                  25                  30          


Ser Ser His Leu Leu Pro Pro Pro Glu Lys Arg Arg Ala Ile Ser Asp 
        35                  40                  45              


Val Arg Arg Thr Phe Cys Leu Phe Val Thr Phe Asp Leu Leu Phe Ile 
    50                  55                  60                  


Ser Leu Leu Trp Ile Ile Glu Leu Asn Thr Asn Thr Gly Ile Arg Lys 
65                  70                  75                  80  


Asn Leu Glu Gln Glu Ile Ile Gln Tyr Asn Phe Lys Thr Ser Phe Phe 
                85                  90                  95      


Asp Ile Phe Val Leu Ala Phe Phe Arg Phe Ser Gly Leu Leu Leu Gly 
            100                 105                 110         


Tyr Ala Val Leu Arg Leu Arg His Trp Trp Val Ile Ala Val Thr Thr 
        115                 120                 125             


Leu Val Ser Ser Ala Phe Leu Ile Val Lys Val Ile Leu Ser Glu Leu 
    130                 135                 140                 


Leu Ser Lys Gly Ala Phe Gly Tyr Leu Leu Pro Ile Val Ser Phe Val 
145                 150                 155                 160 


Leu Ala Trp Leu Glu Thr Trp Phe Leu Asp Phe Lys Val Leu Pro Gln 
                165                 170                 175     


Glu Ala Glu Glu Glu Arg Trp Tyr Leu Ala Ala Gln Val Ala Val Ala 
            180                 185                 190         


Arg Gly Pro Leu Leu Phe Ser Gly Ala Leu Ser Glu Gly Gln Phe Tyr 
        195                 200                 205             


Ser Pro Pro Glu Ser Phe Ala Gly Ser Asp Asn Glu Ser Asp Glu Glu 
    210                 215                 220                 


Val Ala Gly Lys Lys Ser Phe Ser Ala Gln Glu Arg Glu Tyr Ile Arg 
225                 230                 235                 240 


Gln Gly Lys Glu Ala Thr Ala Val Val Asp Gln Ile Leu Ala Gln Glu 
                245                 250                 255     


Glu Asn Trp Lys Phe Glu Lys Asn Asn Glu Tyr Gly Asp Thr Val Tyr 
            260                 265                 270         


Thr Ile Glu Val Pro Phe His Gly Lys Thr Phe Ile Leu Lys Thr Phe 
        275                 280                 285             


Leu Pro Cys Pro Ala Glu Leu Val Tyr Gln Glu Val Ile Leu Gln Pro 
    290                 295                 300                 


Glu Arg Met Val Leu Trp Asn Lys Thr Val Thr Ala Cys Gln Ile Leu 
305                 310                 315                 320 


Gln Arg Val Glu Asp Asn Thr Leu Ile Ser Tyr Asp Val Ser Ala Gly 
                325                 330                 335     


Ala Ala Gly Gly Val Val Ser Pro Arg Asp Phe Val Asn Val Arg Arg 
            340                 345                 350         


Ile Glu Arg Arg Arg Asp Arg Tyr Leu Ser Ser Gly Ile Ala Thr Ser 
        355                 360                 365             


His Ser Ala Lys Pro Pro Thr His Lys Tyr Val Arg Gly Glu Asn Gly 
    370                 375                 380                 


Pro Gly Gly Phe Ile Val Leu Lys Ser Ala Ser Asn Pro Arg Val Cys 
385                 390                 395                 400 


Thr Phe Val Trp Ile Leu Asn Thr Asp Leu Lys Gly Arg Leu Pro Arg 
                405                 410                 415     


Tyr Leu Ile His Gln Ser Leu Ala Ala Thr Met Phe Glu Phe Ala Phe 
            420                 425                 430         


His Leu Arg Gln Arg Ile Ser Glu Leu Gly Ala Arg Ala 
        435                 440                 445 


<210>  3568
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  3568

Met Gly Ala Val Leu Gly Val Phe Ser Leu Ala Ser Trp Val Pro Cys 
1               5                   10                  15      


Leu Cys Ser Gly Ala Ser Cys Leu Leu Cys Ser Cys Cys Pro Asn Ser 
            20                  25                  30          


Lys Asn Ser Thr Val Thr Arg Leu Ile Tyr Ala Phe Ile Leu Leu Leu 
        35                  40                  45              


Ser Thr Val Val Ser Tyr Ile Met Gln Arg Lys Glu Met Glu Thr Tyr 
    50                  55                  60                  


Leu Lys Lys Ile Pro Gly Phe Cys Glu Gly Gly Phe Lys Ile His Glu 
65                  70                  75                  80  


Ala Asp Ile Asn Ala Asp Lys Asp Cys Asp Val Leu Val Gly Tyr Lys 
                85                  90                  95      


Ala Val Tyr Arg Ile Ser Phe Ala Met Ala Ile Phe Phe Phe Val Phe 
            100                 105                 110         


Ser Leu Leu Met Phe Lys Val Lys Thr Ser Lys Asp Leu Arg Ala Ala 
        115                 120                 125             


Val His Asn Gly Phe Trp Phe Phe Lys Ile Ala Ala Leu Ile Gly Ile 
    130                 135                 140                 


Met Val Gly Ser Phe Tyr Ile Pro Gly Gly Tyr Phe Ser Ser Val Trp 
145                 150                 155                 160 


Phe Val Val Gly Met Ile Gly Ala Ala Leu Phe Ile Leu Ile Gln Leu 
                165                 170                 175     


Val Leu Leu Val Asp Phe Ala His Ser Trp Asn Glu Ser Trp Val Asn 
            180                 185                 190         


Arg Met Glu Glu Gly Asn Pro Arg Leu Trp Tyr Ala Ala Leu Leu Ser 
        195                 200                 205             


Phe Thr Ser Ala Phe Tyr Ile Leu Ser Ile Ile Cys Val Gly Leu Leu 
    210                 215                 220                 


Tyr Thr Tyr Tyr Thr Lys Pro Asp Gly Cys Thr Glu Asn Lys Phe Phe 
225                 230                 235                 240 


Ile Ser Ile Asn Leu Ile Leu Cys Val Val Ala Ser Ile Ile Ser Ile 
                245                 250                 255     


His Pro Lys Ile Gln Glu His Gln Pro Arg Ser Gly Leu Leu Gln Ser 
            260                 265                 270         


Ser Leu Ile Thr Leu Tyr Thr Met Tyr Leu Thr Trp Ser Ala Met Ser 
        275                 280                 285             


Asn Glu Pro Asp Arg Ser Cys Asn Pro Asn Leu Met Ser Phe Ile Thr 
    290                 295                 300                 


Arg Ile Thr Ala Pro Thr Leu Ala Pro Gly Asn Ser Thr Ala Val Val 
305                 310                 315                 320 


Pro Thr Pro Thr Pro Pro Ser Lys Ser Gly Ser Leu Leu Asp Ser Asp 
                325                 330                 335     


Asn Phe Ile Gly Leu Phe Val Phe Val Leu Cys Leu Leu Tyr Ser Ser 
            340                 345                 350         


Ile Arg Thr Ser Thr Asn Ser Gln Val Asp Lys Leu Thr Leu Ser Gly 
        355                 360                 365             


Ser Asp Ser Val Ile Leu Gly Asp Thr Thr Thr Ser Gly Ala Ser Asp 
    370                 375                 380                 


Glu Glu Asp Gly Gln Pro Arg Arg Ala Val Asp Asn Glu Lys Glu Gly 
385                 390                 395                 400 


Val Gln Tyr Ser Tyr Ser Leu Phe His Leu Met Leu Cys Leu Ala Ser 
                405                 410                 415     


Leu Tyr Ile Met Met Thr Leu Thr Ser Trp Tyr Ser Pro Asp Ala Lys 
            420                 425                 430         


Phe Gln Ser Met Thr Ser Lys Trp Pro Ala Val Trp Val Lys Ile Ser 
        435                 440                 445             


Ser Ser Trp Val Cys Leu Leu Leu Tyr Val Trp Thr Leu Val Ala Pro 
    450                 455                 460                 


Leu Val Leu Thr Ser Arg Asp Phe Ser 
465                 470             


<210>  3569
<211>  667
<212>  PRT
<213>  Homo sapiens

<400>  3569

Met Ala Ala Glu Thr Leu Leu Ser Ser Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Pro Ala Ser Leu Thr Gly Gly Val Gly Ser Leu Asn 
            20                  25                  30          


Leu Glu Glu Leu Ser Glu Met Arg Tyr Gly Ile Glu Ile Leu Pro Leu 
        35                  40                  45              


Pro Val Met Gly Gly Gln Ser Gln Ser Ser Asp Val Val Ile Val Ser 
    50                  55                  60                  


Ser Lys Tyr Lys Gln Arg Tyr Glu Cys Arg Leu Pro Ala Gly Ala Ile 
65                  70                  75                  80  


His Phe Gln Arg Glu Arg Glu Glu Glu Thr Pro Ala Tyr Gln Gly Pro 
                85                  90                  95      


Gly Ile Pro Glu Leu Leu Ser Pro Met Arg Asp Ala Pro Cys Leu Leu 
            100                 105                 110         


Lys Thr Lys Asp Trp Trp Thr Tyr Glu Phe Cys Tyr Gly Arg His Ile 
        115                 120                 125             


Gln Gln Tyr His Met Glu Asp Ser Glu Ile Lys Gly Glu Val Leu Tyr 
    130                 135                 140                 


Leu Gly Tyr Tyr Gln Ser Ala Phe Asp Trp Asp Asp Glu Thr Ala Lys 
145                 150                 155                 160 


Ala Ser Lys Gln His Arg Leu Lys Arg Tyr His Ser Gln Thr Tyr Gly 
                165                 170                 175     


Asn Gly Ser Lys Cys Asp Leu Asn Gly Arg Pro Arg Glu Ala Glu Val 
            180                 185                 190         


Arg Phe Leu Cys Asp Glu Gly Ala Gly Ile Ser Gly Asp Tyr Ile Asp 
        195                 200                 205             


Arg Val Asp Glu Pro Leu Ser Cys Ser Tyr Val Leu Thr Ile Arg Thr 
    210                 215                 220                 


Pro Arg Leu Cys Pro His Pro Leu Leu Arg Pro Pro Pro Ser Ala Ala 
225                 230                 235                 240 


Pro Gln Ala Ile Leu Cys His Pro Ser Leu Gln Pro Glu Glu Tyr Met 
                245                 250                 255     


Ala Tyr Val Gln Arg Gln Ala Asp Ser Lys Gln Tyr Gly Asp Lys Ile 
            260                 265                 270         


Ile Glu Glu Leu Gln Asp Leu Gly Pro Gln Val Trp Ser Glu Thr Lys 
        275                 280                 285             


Ser Gly Val Ala Pro Gln Lys Met Ala Gly Ala Ser Pro Thr Lys Asp 
    290                 295                 300                 


Asp Ser Lys Asp Ser Asp Phe Trp Lys Met Leu Asn Glu Pro Glu Asp 
305                 310                 315                 320 


Gln Ala Pro Gly Gly Glu Glu Val Pro Ala Glu Glu Gln Asp Pro Ser 
                325                 330                 335     


Pro Glu Ala Ala Asp Ser Ala Ser Gly Ala Pro Asn Asp Phe Gln Asn 
            340                 345                 350         


Asn Val Gln Val Lys Val Ile Arg Ser Pro Ala Asp Leu Ile Arg Phe 
        355                 360                 365             


Ile Glu Glu Leu Lys Gly Gly Thr Lys Lys Gly Lys Pro Asn Ile Gly 
    370                 375                 380                 


Gln Glu Gln Pro Val Asp Asp Ala Ala Glu Val Pro Gln Arg Glu Pro 
385                 390                 395                 400 


Glu Lys Glu Arg Gly Asp Pro Glu Arg Gln Arg Glu Met Glu Glu Glu 
                405                 410                 415     


Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Arg Gln Leu 
            420                 425                 430         


Leu Gly Glu Phe Glu Lys Glu Leu Glu Gly Ile Leu Leu Pro Ser Asp 
        435                 440                 445             


Arg Asp Arg Leu Arg Ser Glu Val Lys Ala Gly Met Glu Arg Glu Leu 
    450                 455                 460                 


Glu Asn Ile Ile Gln Glu Thr Glu Lys Glu Leu Asp Pro Asp Gly Leu 
465                 470                 475                 480 


Lys Lys Glu Ser Glu Arg Asp Arg Ala Met Leu Ala Leu Thr Ser Thr 
                485                 490                 495     


Leu Asn Lys Leu Ile Lys Arg Leu Glu Glu Lys Gln Ser Pro Glu Leu 
            500                 505                 510         


Val Lys Lys His Lys Lys Lys Arg Val Val Pro Lys Lys Pro Pro Pro 
        515                 520                 525             


Ser Pro Gln Pro Thr Glu Glu Asp Pro Glu His Arg Val Arg Val Arg 
    530                 535                 540                 


Val Thr Lys Leu Arg Leu Gly Gly Pro Asn Gln Asp Leu Thr Val Leu 
545                 550                 555                 560 


Glu Met Lys Arg Glu Asn Pro Gln Leu Lys Gln Ile Glu Gly Leu Val 
                565                 570                 575     


Lys Glu Leu Leu Glu Arg Glu Gly Leu Thr Ala Ala Gly Lys Ile Glu 
            580                 585                 590         


Ile Lys Ile Val Arg Pro Trp Ala Glu Gly Thr Glu Glu Gly Ala Arg 
        595                 600                 605             


Trp Leu Thr Asp Glu Asp Thr Arg Asn Leu Lys Glu Ile Phe Phe Asn 
    610                 615                 620                 


Ile Leu Val Pro Gly Ala Glu Glu Ala Gln Lys Glu Arg Gln Arg Gln 
625                 630                 635                 640 


Lys Glu Leu Glu Ser Asn Tyr Arg Arg Val Trp Gly Ser Pro Gly Gly 
                645                 650                 655     


Glu Gly Thr Gly Asp Leu Asp Glu Phe Asp Phe 
            660                 665         


<210>  3570
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  3570

Met Val Thr Leu Ala Glu Leu Leu Val Leu Leu Ala Ala Leu Leu Ala 
1               5                   10                  15      


Thr Val Ser Gly Tyr Phe Val Ser Ile Asp Ala His Ala Glu Glu Cys 
            20                  25                  30          


Phe Phe Glu Arg Val Thr Ser Gly Thr Lys Met Gly Leu Ile Phe Glu 
        35                  40                  45              


Val Ala Glu Gly Gly Phe Leu Asp Ile Asp Val Glu Ile Thr Gly Pro 
    50                  55                  60                  


Asp Asn Lys Gly Ile Tyr Lys Gly Asp Arg Glu Ser Ser Gly Lys Tyr 
65                  70                  75                  80  


Thr Phe Ala Ala His Met Asp Gly Thr Tyr Lys Phe Cys Phe Ser Asn 
                85                  90                  95      


Arg Met Ser Thr Met Thr Pro Lys Ile Val Met Phe Thr Ile Asp Ile 
            100                 105                 110         


Gly Glu Ala Pro Lys Gly Gln Asp Met Glu Thr Glu Ala His Gln Asn 
        115                 120                 125             


Lys Leu Glu Glu Met Ile Asn Glu Leu Ala Val Ala Met Thr Ala Val 
    130                 135                 140                 


Lys His Glu Gln Glu Tyr Met Glu Val Arg Glu Arg Ile His Arg Ala 
145                 150                 155                 160 


Ile Asn Asp Asn Thr Asn Ser Arg Val Val Leu Trp Ser Phe Phe Glu 
                165                 170                 175     


Ala Leu Val Leu Val Ala Met Thr Leu Gly Gln Ile Tyr Tyr Leu Lys 
            180                 185                 190         


Arg Phe Phe Glu Val Arg Arg Val Val 
        195                 200     


<210>  3571
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  3571

Met Ala Ala Glu Gly Trp Ile Trp Arg Trp Gly Trp Gly Arg Arg Cys 
1               5                   10                  15      


Leu Gly Arg Pro Gly Leu Leu Gly Pro Gly Pro Gly Pro Thr Thr Pro 
            20                  25                  30          


Leu Phe Leu Leu Leu Leu Leu Gly Ser Val Thr Ala Asp Ile Thr Asp 
        35                  40                  45              


Gly Asn Ser Glu His Leu Lys Arg Glu His Ser Leu Ile Lys Pro Tyr 
    50                  55                  60                  


Gln Gly Val Gly Ser Ser Ser Met Pro Leu Trp Asp Phe Gln Gly Ser 
65                  70                  75                  80  


Thr Met Leu Thr Ser Gln Tyr Val Arg Leu Thr Pro Asp Glu Arg Ser 
                85                  90                  95      


Lys Glu Gly Ser Ile Trp Asn His Gln Pro Cys Phe Leu Lys Asp Trp 
            100                 105                 110         


Glu Met His Val His Phe Lys Val His Gly Thr Gly Lys Lys Asn Leu 
        115                 120                 125             


His Gly Asp Gly Ile Ala Leu Trp Tyr Thr Arg Asp Arg Leu Val Pro 
    130                 135                 140                 


Gly Pro Val Phe Gly Ser Lys Asp Asn Phe His Gly Leu Ala Ile Phe 
145                 150                 155                 160 


Leu Asp Thr Tyr Pro Asn Asp Glu Thr Thr Glu Arg Val Phe Pro Tyr 
                165                 170                 175     


Ile Ser Val Met Val Asn Asn Gly Ser Leu Ser Tyr Asp His Ser Lys 
            180                 185                 190         


Asp Gly Arg Trp Thr Glu Leu Ala Gly Cys Thr Ala Asp Phe Arg Asn 
        195                 200                 205             


Arg Asp His Asp Thr Phe Leu Ala Val Arg Tyr Ser Arg Gly Arg Leu 
    210                 215                 220                 


Thr Val Met Thr Asp Leu Glu Asp Lys Asn Glu Trp Lys Asn Cys Ile 
225                 230                 235                 240 


Asp Ile Thr Gly Val Arg Leu Pro Thr Gly Tyr Tyr Phe Gly Ala Ser 
                245                 250                 255     


Ala Gly Thr Gly Asp Leu Ser Asp Asn His Asp Ile Ile Ser Met Lys 
            260                 265                 270         


Leu Phe Gln Leu Met Val Glu His Thr Pro Asp Glu Glu Ser Ile Asp 
        275                 280                 285             


Trp Thr Lys Ile Glu Pro Ser Val Asn Phe Leu Lys Ser Pro Lys Asp 
    290                 295                 300                 


Asn Val Asp Asp Pro Thr Gly Asn Phe Arg Ser Gly Pro Leu Thr Gly 
305                 310                 315                 320 


Trp Arg Val Phe Leu Leu Leu Leu Cys Ala Leu Leu Gly Ile Val Val 
                325                 330                 335     


Cys Ala Val Val Gly Ala Val Val Phe Gln Lys Arg Gln Glu Arg Asn 
            340                 345                 350         


Lys Arg Phe Tyr 
        355     


<210>  3572
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  3572

Met Ala Ala Ala Val Pro Arg Ala Ala Phe Leu Ser Pro Leu Leu Pro 
1               5                   10                  15      


Leu Leu Leu Gly Phe Leu Leu Leu Ser Ala Pro His Gly Gly Ser Gly 
            20                  25                  30          


Leu His Thr Lys Gly Ala Leu Pro Leu Asp Thr Val Thr Phe Tyr Lys 
        35                  40                  45              


Val Ile Pro Lys Ser Lys Phe Val Leu Val Lys Phe Asp Thr Gln Tyr 
    50                  55                  60                  


Pro Tyr Gly Glu Lys Gln Asp Glu Phe Lys Arg Leu Ala Glu Asn Ser 
65                  70                  75                  80  


Ala Ser Ser Asp Asp Leu Leu Val Ala Glu Val Gly Ile Ser Asp Tyr 
                85                  90                  95      


Gly Asp Lys Leu Asn Met Glu Leu Ser Glu Lys Tyr Lys Leu Asp Lys 
            100                 105                 110         


Glu Ser Tyr Pro Val Phe Tyr Leu Phe Arg Asp Gly Asp Phe Glu Asn 
        115                 120                 125             


Pro Val Pro Tyr Thr Gly Ala Val Lys Val Gly Ala Ile Gln Arg Trp 
    130                 135                 140                 


Leu Lys Gly Gln Gly Val Tyr Leu Gly Met Pro Gly Cys Leu Pro Val 
145                 150                 155                 160 


Tyr Asp Ala Leu Ala Gly Glu Phe Ile Arg Ala Ser Gly Val Glu Ala 
                165                 170                 175     


Arg Gln Ala Leu Leu Lys Gln Gly Gln Asp Asn Leu Ser Ser Val Lys 
            180                 185                 190         


Glu Thr Gln Lys Lys Trp Ala Glu Gln Tyr Leu Lys Ile Met Gly Lys 
        195                 200                 205             


Ile Leu Asp Gln Gly Glu Asp Phe Pro Ala Ser Glu Met Thr Arg Ile 
    210                 215                 220                 


Ala Arg Leu Ile Glu Lys Asn Lys Met Ser Asp Gly Lys Lys Glu Glu 
225                 230                 235                 240 


Leu Gln Lys Ser Leu Asn Ile Leu Thr Ala Phe Gln Lys Lys Gly Ala 
                245                 250                 255     


Glu Lys Glu Glu Leu 
            260     


<210>  3573
<211>  602
<212>  PRT
<213>  Homo sapiens

<400>  3573

Met Pro Ser Ala Lys Gln Arg Gly Ser Lys Gly Gly His Gly Ala Ala 
1               5                   10                  15      


Ser Pro Ser Glu Lys Gly Ala His Pro Ser Gly Gly Ala Asp Asp Val 
            20                  25                  30          


Ala Lys Lys Pro Pro Pro Ala Pro Gln Gln Pro Pro Pro Pro Pro Ala 
        35                  40                  45              


Pro His Pro Gln Gln His Pro Gln Gln His Pro Gln Asn Gln Ala His 
    50                  55                  60                  


Gly Lys Gly Gly His Arg Gly Gly Gly Gly Gly Gly Gly Lys Ser Ser 
65                  70                  75                  80  


Ser Ser Ser Ser Ala Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Ser 
                85                  90                  95      


Ser Ala Ser Cys Ser Arg Arg Leu Gly Arg Ala Leu Asn Phe Leu Phe 
            100                 105                 110         


Tyr Leu Ala Leu Val Ala Ala Ala Ala Phe Ser Gly Trp Cys Val His 
        115                 120                 125             


His Val Leu Glu Glu Val Gln Gln Val Arg Arg Ser His Gln Asp Phe 
    130                 135                 140                 


Ser Arg Gln Arg Glu Glu Leu Gly Gln Gly Leu Gln Gly Val Glu Gln 
145                 150                 155                 160 


Lys Val Gln Ser Leu Gln Ala Thr Phe Gly Thr Phe Glu Ser Ile Leu 
                165                 170                 175     


Arg Ser Ser Gln His Lys Gln Asp Leu Thr Glu Lys Ala Val Lys Gln 
            180                 185                 190         


Gly Glu Ser Glu Val Ser Arg Ile Ser Glu Val Leu Gln Lys Leu Gln 
        195                 200                 205             


Asn Glu Ile Leu Lys Asp Leu Ser Asp Gly Ile His Val Val Lys Asp 
    210                 215                 220                 


Ala Arg Glu Arg Asp Phe Thr Ser Leu Glu Asn Thr Val Glu Glu Arg 
225                 230                 235                 240 


Leu Thr Glu Leu Thr Lys Ser Ile Asn Asp Asn Ile Ala Ile Phe Thr 
                245                 250                 255     


Glu Val Gln Lys Arg Ser Gln Lys Glu Ile Asn Asp Met Lys Ala Lys 
            260                 265                 270         


Val Ala Ser Leu Glu Glu Ser Glu Gly Asn Lys Gln Asp Leu Lys Ala 
        275                 280                 285             


Leu Lys Glu Ala Val Lys Glu Ile Gln Thr Ser Ala Lys Ser Arg Glu 
    290                 295                 300                 


Trp Asp Met Glu Ala Leu Arg Ser Thr Leu Gln Thr Met Glu Ser Asp 
305                 310                 315                 320 


Ile Tyr Thr Glu Val Arg Glu Leu Val Ser Leu Lys Gln Glu Gln Gln 
                325                 330                 335     


Ala Phe Lys Glu Ala Ala Asp Thr Glu Arg Leu Ala Leu Gln Ala Leu 
            340                 345                 350         


Thr Glu Lys Leu Leu Arg Ser Glu Glu Ser Val Ser Arg Leu Pro Glu 
        355                 360                 365             


Glu Ile Arg Arg Leu Glu Glu Glu Leu Arg Gln Leu Lys Ser Asp Ser 
    370                 375                 380                 


His Gly Pro Lys Glu Asp Gly Gly Phe Arg His Ser Glu Ala Phe Glu 
385                 390                 395                 400 


Ala Leu Gln Gln Lys Ser Gln Gly Leu Asp Ser Arg Leu Gln His Val 
                405                 410                 415     


Glu Asp Gly Val Leu Ser Met Gln Val Ala Ser Ala Arg Gln Thr Glu 
            420                 425                 430         


Ser Leu Glu Ser Leu Leu Ser Lys Ser Gln Glu His Glu Gln Arg Leu 
        435                 440                 445             


Ala Ala Leu Gln Gly Arg Leu Glu Gly Leu Gly Ser Ser Glu Ala Asp 
    450                 455                 460                 


Gln Asp Gly Leu Ala Ser Thr Val Arg Ser Leu Gly Glu Thr Gln Leu 
465                 470                 475                 480 


Val Leu Tyr Gly Asp Val Glu Glu Leu Lys Arg Ser Val Gly Glu Leu 
                485                 490                 495     


Pro Ser Thr Val Glu Ser Leu Gln Lys Val Gln Glu Gln Val His Thr 
            500                 505                 510         


Leu Leu Ser Gln Asp Gln Ala Gln Ala Ala Arg Leu Pro Pro Gln Asp 
        515                 520                 525             


Phe Leu Asp Arg Leu Ser Ser Leu Asp Asn Leu Lys Ala Ser Val Ser 
    530                 535                 540                 


Gln Val Glu Ala Asp Leu Lys Met Leu Arg Thr Ala Val Asp Ser Leu 
545                 550                 555                 560 


Val Ala Tyr Ser Val Lys Ile Glu Thr Asn Glu Asn Asn Leu Glu Ser 
                565                 570                 575     


Ala Lys Gly Leu Leu Asp Asp Leu Arg Asn Asp Leu Asp Arg Leu Phe 
            580                 585                 590         


Val Lys Val Glu Lys Ile His Glu Lys Val 
        595                 600         


<210>  3574
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  3574

Met Ser Gly Leu Ser Gly Pro Pro Ala Arg Arg Gly Pro Phe Pro Leu 
1               5                   10                  15      


Ala Leu Leu Leu Leu Phe Leu Leu Gly Pro Arg Leu Val Leu Ala Ile 
            20                  25                  30          


Ser Phe His Leu Pro Ile Asn Ser Arg Lys Cys Leu Arg Glu Glu Ile 
        35                  40                  45              


His Lys Asp Leu Leu Val Thr Gly Ala Tyr Glu Ile Ser Asp Gln Ser 
    50                  55                  60                  


Gly Gly Ala Gly Gly Leu Arg Ser His Leu Lys Ile Thr Asp Ser Ala 
65                  70                  75                  80  


Gly His Ile Leu Tyr Ser Lys Glu Asp Ala Thr Lys Gly Lys Phe Ala 
                85                  90                  95      


Phe Thr Thr Glu Asp Tyr Asp Met Phe Glu Val Cys Phe Glu Ser Lys 
            100                 105                 110         


Gly Thr Gly Arg Ile Pro Asp Gln Leu Val Ile Leu Asp Met Lys His 
        115                 120                 125             


Gly Val Glu Ala Lys Asn Tyr Glu Glu Ile Ala Lys Val Glu Lys Leu 
    130                 135                 140                 


Lys Pro Leu Glu Val Glu Leu Arg Arg Leu Glu Asp Leu Ser Glu Ser 
145                 150                 155                 160 


Ile Val Asn Asp Phe Ala Tyr Met Lys Lys Arg Glu Glu Glu Met Arg 
                165                 170                 175     


Asp Thr Asn Glu Ser Thr Asn Thr Arg Val Leu Tyr Phe Ser Ile Phe 
            180                 185                 190         


Ser Met Phe Cys Leu Ile Gly Leu Ala Thr Trp Gln Val Phe Tyr Leu 
        195                 200                 205             


Arg Arg Phe Phe Lys Ala Lys Lys Leu Ile Glu 
    210                 215                 


<210>  3575
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  3575

Met Val Thr Arg Phe Leu Gly Pro Arg Tyr Arg Glu Leu Val Lys Asn 
1               5                   10                  15      


Trp Val Pro Thr Ala Tyr Thr Trp Gly Ala Val Gly Ala Val Gly Leu 
            20                  25                  30          


Val Trp Ala Thr Asp Trp Arg Leu Ile Leu Asp Trp Val Pro Tyr Ile 
        35                  40                  45              


Asn Gly Lys Phe Lys Lys Asp Asn 
    50                  55      


<210>  3576
<211>  590
<212>  PRT
<213>  Homo sapiens

<400>  3576

Met Thr Leu Thr Leu Ser Val Leu Ile Cys Leu Gly Leu Ser Val Gly 
1               5                   10                  15      


Pro Arg Thr Cys Val Gln Ala Gly Thr Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Ala Ser Val Ile Ala Arg Gly Lys Pro Val Thr Leu Trp 
        35                  40                  45              


Cys Gln Gly Pro Leu Glu Thr Glu Glu Tyr Arg Leu Asp Lys Glu Gly 
    50                  55                  60                  


Leu Pro Trp Ala Arg Lys Arg Gln Asn Pro Leu Glu Pro Gly Ala Lys 
65                  70                  75                  80  


Ala Lys Phe His Ile Pro Ser Thr Val Tyr Asp Ser Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys Tyr Tyr Glu Thr Pro Ala Gly Trp Ser Glu Pro Ser Asp Pro 
            100                 105                 110         


Leu Glu Leu Val Ala Thr Gly Phe Tyr Ala Glu Pro Thr Leu Leu Ala 
        115                 120                 125             


Leu Pro Ser Pro Val Val Ala Ser Gly Gly Asn Val Thr Leu Gln Cys 
    130                 135                 140                 


Asp Thr Leu Asp Gly Leu Leu Thr Phe Val Leu Val Glu Glu Glu Gln 
145                 150                 155                 160 


Lys Leu Pro Arg Thr Leu Tyr Ser Gln Lys Leu Pro Lys Gly Pro Ser 
                165                 170                 175     


Gln Ala Leu Phe Pro Val Gly Pro Val Thr Pro Ser Cys Arg Trp Arg 
            180                 185                 190         


Phe Arg Cys Tyr Tyr Tyr Tyr Arg Lys Asn Pro Gln Val Trp Ser Asn 
        195                 200                 205             


Pro Ser Asp Leu Leu Glu Ile Leu Val Pro Gly Val Ser Arg Lys Pro 
    210                 215                 220                 


Ser Leu Leu Ile Pro Gln Gly Ser Val Val Ala Arg Gly Gly Ser Leu 
225                 230                 235                 240 


Thr Leu Gln Cys Arg Ser Asp Val Gly Tyr Asp Ile Phe Val Leu Tyr 
                245                 250                 255     


Lys Glu Gly Glu His Asp Leu Val Gln Gly Ser Gly Gln Gln Pro Gln 
            260                 265                 270         


Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg Ser 
        275                 280                 285             


His Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Pro Arg 
    290                 295                 300                 


Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Ala Gly Leu Ile 
305                 310                 315                 320 


Pro Asp Ile Pro Ala Leu Ser Val Gln Pro Gly Pro Lys Val Ala Ser 
                325                 330                 335     


Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Trp His Gln Ile Asp Thr 
            340                 345                 350         


Phe Phe Leu Thr Lys Glu Gly Ala Ala His Pro Pro Leu Cys Leu Lys 
        355                 360                 365             


Ser Lys Tyr Gln Ser Tyr Arg His Gln Ala Glu Phe Ser Met Ser Pro 
    370                 375                 380                 


Val Thr Ser Ala Gln Gly Gly Thr Tyr Arg Cys Tyr Ser Ala Ile Arg 
385                 390                 395                 400 


Ser Tyr Pro Tyr Leu Leu Ser Ser Pro Ser Tyr Pro Gln Glu Leu Val 
                405                 410                 415     


Val Ser Gly Pro Ser Gly Asp Pro Ser Leu Ser Pro Thr Gly Ser Thr 
            420                 425                 430         


Pro Thr Pro Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Leu Asp 
        435                 440                 445             


Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Thr Gly Val Ser 
    450                 455                 460                 


Val Ala Phe Val Leu Leu Leu Phe Leu Leu Leu Phe Leu Leu Leu Arg 
465                 470                 475                 480 


His Arg His Gln Ser Lys His Arg Thr Ser Ala His Phe Tyr Arg Pro 
                485                 490                 495     


Ala Gly Ala Ala Gly Pro Glu Pro Lys Asp Gln Gly Leu Gln Lys Arg 
            500                 505                 510         


Ala Ser Pro Val Ala Asp Ile Gln Glu Glu Ile Leu Asn Ala Ala Val 
        515                 520                 525             


Lys Asp Thr Gln Pro Lys Asp Gly Val Glu Met Asp Ala Arg Ala Ala 
    530                 535                 540                 


Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu 
545                 550                 555                 560 


Thr Leu Arg Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Arg Glu 
                565                 570                 575     


Pro Pro Ala Glu Pro Ser Ile Tyr Ala Pro Leu Ala Ile His 
            580                 585                 590 


<210>  3577
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  3577

Met Glu Ala Pro Leu Gln Thr Glu Met Val Glu Leu Val Pro Asn Gly 
1               5                   10                  15      


Lys His Ser Glu Gly Leu Leu Pro Val Ile Thr Pro Met Ala Gly Asn 
            20                  25                  30          


Gln Arg Val Glu Asp Pro Ala Arg Ser Cys Met Glu Gly Lys Ser Phe 
        35                  40                  45              


Leu Gln Lys Ser Pro Ser Lys Glu Pro His Phe Thr Asp Phe Glu Gly 
    50                  55                  60                  


Lys Thr Ser Phe Gly Met Ser Val Phe Asn Leu Ser Asn Ala Ile Met 
65                  70                  75                  80  


Gly Ser Gly Ile Leu Gly Leu Ala Tyr Ala Met Ala Asn Thr Gly Ile 
                85                  90                  95      


Ile Leu Phe Leu Phe Leu Leu Thr Ala Val Ala Leu Leu Ser Ser Tyr 
            100                 105                 110         


Ser Ile His Leu Leu Leu Lys Ser Ser Gly Val Val Gly Ile Arg Ala 
        115                 120                 125             


Tyr Glu Gln Leu Gly Tyr Arg Ala Phe Gly Thr Pro Gly Lys Leu Ala 
    130                 135                 140                 


Ala Ala Leu Ala Ile Thr Leu Gln Asn Ile Gly Ala Met Ser Ser Tyr 
145                 150                 155                 160 


Leu Tyr Ile Ile Lys Ser Glu Leu Pro Leu Val Ile Gln Thr Phe Leu 
                165                 170                 175     


Asn Leu Glu Glu Lys Thr Ser Asp Trp Tyr Met Asn Gly Asn Tyr Leu 
            180                 185                 190         


Val Ile Leu Val Ser Val Thr Ile Ile Leu Pro Leu Ala Leu Met Arg 
        195                 200                 205             


Gln Leu Gly Tyr Leu Gly Tyr Ser Ser Gly Phe Ser Leu Ser Cys Met 
    210                 215                 220                 


Val Phe Phe Leu Ile Ala Val Ile Tyr Lys Lys Phe His Val Pro Cys 
225                 230                 235                 240 


Pro Leu Pro Pro Asn Phe Asn Asn Thr Thr Gly Asn Phe Ser His Val 
                245                 250                 255     


Glu Ile Val Lys Glu Lys Val Gln Leu Gln Val Glu Pro Glu Ala Ser 
            260                 265                 270         


Ala Phe Cys Thr Pro Ser Tyr Phe Thr Leu Asn Ser Gln Thr Ala Tyr 
        275                 280                 285             


Thr Ile Pro Ile Met Ala Phe Ala Phe Val Cys His Pro Glu Val Leu 
    290                 295                 300                 


Pro Ile Tyr Thr Glu Leu Lys Asp Pro Ser Lys Lys Lys Met Gln His 
305                 310                 315                 320 


Ile Ser Asn Leu Ser Ile Ala Val Met Tyr Ile Met Tyr Phe Leu Ala 
                325                 330                 335     


Ala Leu Phe Gly Tyr Leu Thr Phe Tyr Asn Gly Val Glu Ser Glu Leu 
            340                 345                 350         


Leu His Thr Tyr Ser Lys Val Asp Pro Phe Asp Val Leu Ile Leu Cys 
        355                 360                 365             


Val Arg Val Ala Val Leu Thr Ala Val Thr Leu Thr Val Pro Ile Val 
    370                 375                 380                 


Leu Phe Pro Val Arg Arg Ala Ile Gln Gln Met Leu Phe Pro Asn Gln 
385                 390                 395                 400 


Glu Phe Ser Trp Leu Arg His Val Leu Ile Ala Val Gly Leu Leu Thr 
                405                 410                 415     


Cys Ile Asn Leu Leu Val Ile Phe Ala Pro Asn Ile Leu Gly Ile Phe 
            420                 425                 430         


Gly Val Ile Gly Ala Thr Ser Ala Pro Phe Leu Ile Phe Ile Phe Pro 
        435                 440                 445             


Ala Ile Phe Tyr Phe Arg Ile Met Pro Thr Glu Lys Glu Pro Ala Arg 
    450                 455                 460                 


Ser Thr Pro Lys Ile Leu Ala Leu Cys Phe Ala Met Leu Gly Phe Leu 
465                 470                 475                 480 


Leu Met Thr Met Ser Leu Ser Phe Ile Ile Ile Asp Trp Ala Ser Gly 
                485                 490                 495     


Thr Ser Arg His Gly Gly Asn His 
            500                 


<210>  3578
<211>  632
<212>  PRT
<213>  Homo sapiens

<400>  3578

Met Glu Thr Pro Ala Ala Ala Ala Pro Ala Gly Ser Leu Phe Pro Ser 
1               5                   10                  15      


Phe Leu Leu Leu Ala Cys Gly Thr Leu Val Ala Ala Leu Leu Gly Ala 
            20                  25                  30          


Ala His Arg Leu Gly Leu Phe Tyr Gln Leu Leu His Lys Val Asp Lys 
        35                  40                  45              


Ala Ser Val Arg His Gly Gly Glu Asn Val Ala Ala Val Leu Arg Ala 
    50                  55                  60                  


His Gly Val Arg Phe Ile Phe Thr Leu Val Gly Gly His Ile Ser Pro 
65                  70                  75                  80  


Leu Leu Val Ala Cys Glu Lys Leu Gly Ile Arg Val Val Asp Thr Arg 
                85                  90                  95      


His Glu Val Thr Ala Val Phe Ala Ala Asp Ala Met Ala Arg Leu Ser 
            100                 105                 110         


Gly Thr Val Gly Val Ala Ala Val Thr Ala Gly Pro Gly Leu Thr Asn 
        115                 120                 125             


Thr Val Thr Ala Val Lys Asn Ala Gln Met Ala Gln Ser Pro Ile Leu 
    130                 135                 140                 


Leu Leu Gly Gly Ala Ala Ser Thr Leu Leu Gln Asn Arg Gly Ala Leu 
145                 150                 155                 160 


Gln Ala Val Asp Gln Leu Ser Leu Phe Arg Pro Leu Cys Lys Phe Cys 
                165                 170                 175     


Val Ser Val Arg Arg Val Arg Asp Ile Val Pro Thr Leu Arg Ala Ala 
            180                 185                 190         


Met Ala Ala Ala Gln Ser Gly Thr Pro Gly Pro Val Phe Val Glu Leu 
        195                 200                 205             


Pro Val Asp Val Leu Tyr Pro Tyr Phe Met Val Gln Lys Glu Met Val 
    210                 215                 220                 


Pro Ala Lys Pro Pro Lys Gly Leu Val Gly Arg Val Val Ser Trp Tyr 
225                 230                 235                 240 


Leu Glu Asn Tyr Leu Ala Asn Leu Phe Ala Gly Ala Trp Glu Pro Gln 
                245                 250                 255     


Pro Glu Gly Pro Leu Pro Leu Asp Ile Pro Gln Ala Ser Pro Gln Gln 
            260                 265                 270         


Val Gln Arg Cys Val Glu Ile Leu Ser Arg Ala Lys Arg Pro Leu Met 
        275                 280                 285             


Val Leu Gly Ser Gln Ala Leu Leu Thr Pro Thr Ser Ala Asp Lys Leu 
    290                 295                 300                 


Arg Ala Ala Val Glu Thr Leu Gly Val Pro Cys Phe Leu Gly Gly Met 
305                 310                 315                 320 


Ala Arg Gly Leu Leu Gly Arg Asn His Pro Leu His Ile Arg Glu Asn 
                325                 330                 335     


Arg Ser Ala Ala Leu Lys Lys Ala Asp Val Ile Val Leu Ala Gly Thr 
            340                 345                 350         


Val Cys Asp Phe Arg Leu Ser Tyr Gly Arg Val Leu Ser His Ser Ser 
        355                 360                 365             


Lys Ile Ile Ile Val Asn Arg Asn Arg Glu Glu Met Leu Leu Asn Ser 
    370                 375                 380                 


Asp Ile Phe Trp Lys Pro Gln Glu Ala Val Gln Gly Asp Val Gly Ser 
385                 390                 395                 400 


Phe Val Leu Lys Leu Val Glu Gly Leu Gln Gly Gln Thr Trp Ala Pro 
                405                 410                 415     


Asp Trp Val Glu Glu Leu Arg Glu Ala Asp Arg Gln Lys Glu Gln Thr 
            420                 425                 430         


Phe Arg Glu Lys Ala Ala Met Pro Val Ala Gln His Leu Asn Pro Val 
        435                 440                 445             


Gln Val Leu Gln Leu Val Glu Glu Thr Leu Pro Asp Asn Ser Ile Leu 
    450                 455                 460                 


Val Val Asp Gly Gly Asp Phe Val Gly Thr Ala Ala His Leu Val Gln 
465                 470                 475                 480 


Pro Arg Gly Pro Leu Arg Trp Leu Asp Pro Gly Ala Phe Gly Thr Leu 
                485                 490                 495     


Gly Val Gly Ala Gly Phe Ala Leu Gly Ala Lys Leu Cys Arg Pro Asp 
            500                 505                 510         


Ala Glu Val Trp Cys Leu Phe Gly Asp Gly Ala Phe Gly Tyr Ser Leu 
        515                 520                 525             


Ile Glu Phe Asp Thr Phe Val Arg His Lys Ile Pro Val Met Ala Leu 
    530                 535                 540                 


Val Gly Asn Asp Ala Gly Trp Thr Gln Ile Ser Arg Glu Gln Val Pro 
545                 550                 555                 560 


Ser Leu Gly Ser Asn Val Ala Cys Gly Leu Ala Tyr Thr Asp Tyr His 
                565                 570                 575     


Lys Ala Ala Met Gly Leu Gly Ala Arg Gly Leu Leu Leu Ser Arg Glu 
            580                 585                 590         


Asn Glu Asp Gln Val Val Lys Val Leu His Asp Ala Gln Gln Gln Cys 
        595                 600                 605             


Arg Asp Gly His Pro Val Val Val Asn Ile Leu Ile Gly Arg Thr Asp 
    610                 615                 620                 


Phe Arg Asp Gly Ser Ile Ala Val 
625                 630         


<210>  3579
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  3579

Met Ile Pro Thr Phe Thr Ala Leu Leu Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Met Gln Ala Gly Pro Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Ser Trp Gly Asn Ser Val Thr Ile Trp 
        35                  40                  45              


Cys Gln Gly Thr Leu Glu Ala Arg Glu Tyr Arg Leu Asp Lys Glu Glu 
    50                  55                  60                  


Ser Pro Ala Pro Trp Asp Arg Gln Asn Pro Leu Glu Pro Lys Asn Lys 
65                  70                  75                  80  


Ala Arg Phe Ser Ile Pro Ser Met Thr Glu Asp Tyr Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys Tyr Tyr Arg Ser Pro Val Gly Trp Ser Gln Pro Ser Asp Pro 
            100                 105                 110         


Leu Glu Leu Val Met Thr Gly Ala Tyr Ser Lys Pro Thr Leu Ser Ala 
        115                 120                 125             


Leu Pro Ser Pro Leu Val Thr Ser Gly Lys Ser Val Thr Leu Leu Cys 
    130                 135                 140                 


Gln Ser Arg Ser Pro Met Asp Thr Phe Leu Leu Ile Lys Glu Arg Ala 
145                 150                 155                 160 


Ala His Pro Leu Leu His Leu Arg Ser Glu His Gly Ala Gln Gln His 
                165                 170                 175     


Gln Ala Glu Phe Pro Met Ser Pro Val Thr Ser Val His Gly Gly Thr 
            180                 185                 190         


Tyr Arg Cys Phe Ser Ser His Gly Phe Ser His Tyr Leu Leu Ser His 
        195                 200                 205             


Pro Ser Asp Pro Leu Glu Leu Ile Val Ser Gly Ser Leu Glu Gly Pro 
    210                 215                 220                 


Arg Pro Ser Pro Thr Arg Ser Val Ser Thr Ala Ala Gly Pro Glu Asp 
225                 230                 235                 240 


Gln Pro Leu Met Pro Thr Gly Ser Val Pro His Ser Gly Leu Arg Arg 
                245                 250                 255     


His Trp Glu Val Leu Ile Gly Val Leu Val Val Ser Ile Leu Leu Leu 
            260                 265                 270         


Ser Leu Leu Leu Phe Leu Leu Leu Gln His Trp Arg Gln Gly Lys His 
        275                 280                 285             


Arg Thr Leu Ala Gln Arg Gln Ala Asp Phe Gln Arg Pro Pro Gly Ala 
    290                 295                 300                 


Ala Glu Pro Glu Pro Lys Asp Gly Gly Leu Gln Arg Arg Ser Ser Pro 
305                 310                 315                 320 


Ala Ala Asp Val Gln Gly Glu Asn Phe Cys Ala Ala Val Lys Asn Thr 
                325                 330                 335     


Gln Pro Glu Asp Gly Val Glu Met Asp Thr Arg Gln Ser Pro His Asp 
            340                 345                 350         


Glu Asp Pro Gln Ala Val Thr Tyr Ala Lys Val Lys His Ser Arg Pro 
        355                 360                 365             


Arg Arg Glu Met Ala Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu 
    370                 375                 380                 


Asp Thr Lys Asp Arg Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu 
385                 390                 395                 400 


Ala Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Arg Leu His 
                405                 410                 415     


Ser Phe Thr Leu Arg Gln Lys Ala Thr Glu Pro Pro Pro Ser Gln Glu 
            420                 425                 430         


Gly Ala Ser Pro Ala Glu Pro Ser Val Tyr Ala Thr Leu Ala Ile His 
        435                 440                 445             


<210>  3580
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  3580

Met Arg Val Thr Leu Ala Thr Ile Ala Trp Met Val Ser Phe Val Ser 
1               5                   10                  15      


Asn Tyr Ser His Thr Ala Asn Ile Leu Pro Asp Ile Glu Asn Glu Asp 
            20                  25                  30          


Phe Ile Lys Asp Cys Val Arg Ile His Asn Lys Phe Arg Ser Glu Val 
        35                  40                  45              


Lys Pro Thr Ala Ser Asp Met Leu Tyr Met Thr Trp Asp Pro Ala Leu 
    50                  55                  60                  


Ala Gln Ile Ala Lys Ala Trp Ala Ser Asn Cys Gln Phe Ser His Asn 
65                  70                  75                  80  


Thr Arg Leu Lys Pro Pro His Lys Leu His Pro Asn Phe Thr Ser Leu 
                85                  90                  95      


Gly Glu Asn Ile Trp Thr Gly Ser Val Pro Ile Phe Ser Val Ser Ser 
            100                 105                 110         


Ala Ile Thr Asn Trp Tyr Asp Glu Ile Gln Asp Tyr Asp Phe Lys Thr 
        115                 120                 125             


Arg Ile Cys Lys Lys Val Cys Gly His Tyr Thr Gln Val Val Trp Ala 
    130                 135                 140                 


Asp Ser Tyr Lys Val Gly Cys Ala Val Gln Phe Cys Pro Lys Val Ser 
145                 150                 155                 160 


Gly Phe Asp Ala Leu Ser Asn Gly Ala His Phe Ile Cys Asn Tyr Gly 
                165                 170                 175     


Pro Gly Gly Asn Tyr Pro Thr Trp Pro Tyr Lys Arg Gly Ala Thr Cys 
            180                 185                 190         


Ser Ala Cys Pro Asn Asn Asp Lys Cys Leu Asp Asn Leu Cys Val Asn 
        195                 200                 205             


Arg Gln Arg Asp Gln Val Lys Arg Tyr Tyr Ser Val Val Tyr Pro Gly 
    210                 215                 220                 


Trp Pro Ile Tyr Pro Arg Asn Arg Tyr Thr Ser Leu Phe Leu Ile Val 
225                 230                 235                 240 


Asn Ser Val Ile Leu Ile Leu Ser Val Ile Ile Thr Ile Leu Val Gln 
                245                 250                 255     


His Lys Tyr Pro Asn Leu Val Leu Leu Asp 
            260                 265     


<210>  3581
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  3581

Met Asn Ile Phe Arg Leu Thr Gly Asp Leu Ser His Leu Ala Ala Ile 
1               5                   10                  15      


Val Ile Leu Leu Leu Lys Ile Trp Lys Thr Arg Ser Cys Ala Gly Ile 
            20                  25                  30          


Ser Gly Lys Ser Gln Leu Leu Phe Ala Leu Val Phe Thr Thr Arg Tyr 
        35                  40                  45              


Leu Asp Leu Phe Thr Ser Phe Ile Ser Leu Tyr Asn Thr Ser Met Lys 
    50                  55                  60                  


Val Ile Tyr Leu Ala Cys Ser Tyr Ala Thr Val Tyr Leu Ile Tyr Leu 
65                  70                  75                  80  


Lys Phe Lys Ala Thr Tyr Asp Gly Asn His Asp Thr Phe Arg Val Glu 
                85                  90                  95      


Phe Leu Val Val Pro Val Gly Gly Leu Ser Phe Leu Val Asn His Asp 
            100                 105                 110         


Phe Ser Pro Leu Glu Ile Leu Trp Thr Phe Ser Ile Tyr Leu Glu Ser 
        115                 120                 125             


Val Ala Ile Leu Pro Gln Leu Phe Met Ile Ser Lys Thr Gly Glu Ala 
    130                 135                 140                 


Glu Thr Ile Thr Thr His Tyr Leu Phe Phe Leu Gly Leu Tyr Arg Ala 
145                 150                 155                 160 


Leu Tyr Leu Val Asn Trp Ile Trp Arg Phe Tyr Phe Glu Gly Phe Phe 
                165                 170                 175     


Asp Leu Ile Ala Val Val Ala Gly Val Val Gln Thr Ile Leu Tyr Cys 
            180                 185                 190         


Asp Phe Phe Tyr Leu Tyr Ile Thr Lys Val Leu Lys Gly Lys Lys Leu 
        195                 200                 205             


Ser Leu Pro Ala 
    210         


<210>  3582
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  3582

Met Asn Val Phe Arg Ile Leu Gly Asp Leu Ser His Leu Leu Ala Met 
1               5                   10                  15      


Ile Leu Leu Leu Gly Lys Ile Trp Arg Ser Lys Cys Cys Lys Gly Ile 
            20                  25                  30          


Ser Gly Lys Ser Gln Ile Leu Phe Ala Leu Val Phe Thr Thr Arg Tyr 
        35                  40                  45              


Leu Asp Leu Phe Thr Asn Phe Ile Ser Ile Tyr Asn Thr Val Met Lys 
    50                  55                  60                  


Val Val Phe Leu Leu Cys Ala Tyr Val Thr Val Tyr Met Ile Tyr Gly 
65                  70                  75                  80  


Lys Phe Arg Lys Thr Phe Asp Ser Glu Asn Asp Thr Phe Arg Leu Glu 
                85                  90                  95      


Phe Leu Leu Val Pro Val Ile Gly Leu Ser Phe Leu Glu Asn Tyr Ser 
            100                 105                 110         


Phe Thr Leu Leu Glu Ile Leu Trp Thr Phe Ser Ile Tyr Leu Glu Ser 
        115                 120                 125             


Val Ala Ile Leu Pro Gln Leu Phe Met Ile Ser Lys Thr Gly Glu Ala 
    130                 135                 140                 


Glu Thr Ile Thr Thr His Tyr Leu Phe Phe Leu Gly Leu Tyr Arg Ala 
145                 150                 155                 160 


Leu Tyr Leu Ala Asn Trp Ile Arg Arg Tyr Gln Thr Glu Asn Phe Tyr 
                165                 170                 175     


Asp Gln Ile Ala Val Val Ser Gly Val Val Gln Thr Ile Phe Tyr Cys 
            180                 185                 190         


Asp Phe Phe Tyr Leu Tyr Val Thr Lys Val Leu Lys Gly Lys Lys Leu 
        195                 200                 205             


Ser Leu Pro Met Pro Ile 
    210                 


<210>  3583
<211>  483
<212>  PRT
<213>  Homo sapiens

<400>  3583

Met Gly Asp Asp Arg Pro Phe Val Cys Asn Ala Pro Gly Cys Gly Gln 
1               5                   10                  15      


Arg Phe Thr Asn Glu Asp His Leu Ala Val His Lys His Lys His Glu 
            20                  25                  30          


Met Thr Leu Lys Phe Gly Pro Ala Arg Thr Asp Ser Val Ile Ile Ala 
        35                  40                  45              


Asp Gln Thr Pro Thr Pro Thr Arg Phe Leu Lys Asn Cys Glu Glu Val 
    50                  55                  60                  


Gly Leu Phe Asn Glu Leu Ala Ser Ser Phe Glu His Glu Phe Lys Lys 
65                  70                  75                  80  


Ala Ala Asp Glu Asp Glu Lys Lys Ala Ala Ala Gly Pro Leu Asp Met 
                85                  90                  95      


Ser Leu Pro Ser Thr Pro Asp Ile Lys Ile Lys Glu Glu Glu Pro Val 
            100                 105                 110         


Glu Val Asp Ser Ser Pro Pro Asp Ser Pro Ala Ser Ser Pro Cys Ser 
        115                 120                 125             


Pro Pro Leu Lys Glu Lys Glu Val Thr Pro Lys Pro Val Leu Ile Ser 
    130                 135                 140                 


Thr Pro Thr Pro Thr Ile Val Arg Pro Gly Ser Leu Pro Leu His Leu 
145                 150                 155                 160 


Gly Tyr Asp Pro Leu His Pro Thr Leu Pro Ser Pro Thr Ser Val Ile 
                165                 170                 175     


Thr Gln Ala Pro Pro Ser Asn Arg Gln Met Gly Ser Pro Thr Gly Ser 
            180                 185                 190         


Leu Pro Leu Val Met His Leu Ala Asn Gly Gln Thr Met Pro Val Leu 
        195                 200                 205             


Pro Gly Pro Pro Val Gln Met Pro Ser Val Ile Ser Leu Ala Arg Pro 
    210                 215                 220                 


Val Ser Met Val Pro Asn Ile Pro Gly Ile Pro Gly Pro Pro Val Asn 
225                 230                 235                 240 


Ser Ser Gly Ser Ile Ser Pro Ser Gly His Pro Ile Pro Ser Glu Ala 
                245                 250                 255     


Lys Met Arg Leu Lys Ala Thr Leu Thr His Gln Val Ser Ser Ile Asn 
            260                 265                 270         


Gly Gly Cys Gly Met Val Val Gly Thr Ala Ser Thr Met Val Thr Ala 
        275                 280                 285             


Arg Pro Glu Gln Ser Gln Ile Leu Ile Gln His Pro Asp Ala Pro Ser 
    290                 295                 300                 


Pro Ala Gln Pro Gln Val Ser Pro Ala Gln Pro Thr Pro Ser Thr Gly 
305                 310                 315                 320 


Gly Arg Arg Arg Arg Thr Val Asp Glu Asp Pro Asp Glu Arg Arg Gln 
                325                 330                 335     


Arg Phe Leu Glu Arg Asn Arg Ala Ala Ala Ser Arg Cys Arg Gln Lys 
            340                 345                 350         


Arg Lys Leu Trp Val Ser Ser Leu Glu Lys Lys Ala Glu Glu Leu Thr 
        355                 360                 365             


Ser Gln Asn Ile Gln Leu Ser Asn Glu Val Thr Leu Leu Arg Asn Glu 
    370                 375                 380                 


Val Ala Gln Leu Lys Gln Leu Leu Leu Ala His Lys Asp Cys Pro Val 
385                 390                 395                 400 


Thr Ala Leu Gln Lys Lys Thr Gln Gly Tyr Leu Glu Ser Pro Lys Glu 
                405                 410                 415     


Ser Ser Glu Pro Thr Gly Ser Pro Ala Pro Val Ile Gln His Ser Ser 
            420                 425                 430         


Ala Thr Ala Pro Ser Asn Gly Leu Ser Val Arg Ser Ala Ala Glu Ala 
        435                 440                 445             


Val Ala Thr Ser Val Leu Thr Gln Met Ala Ser Gln Arg Thr Glu Leu 
    450                 455                 460                 


Ser Met Pro Ile Gln Ser His Val Ile Met Thr Pro Gln Ser Gln Ser 
465                 470                 475                 480 


Ala Gly Arg 
            


<210>  3584
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  3584

Met Met Ala Ala Gly Ala Ala Leu Ala Leu Ala Leu Trp Leu Leu Met 
1               5                   10                  15      


Pro Pro Val Glu Val Gly Gly Ala Gly Pro Pro Pro Ile Gln Asp Gly 
            20                  25                  30          


Glu Phe Thr Phe Leu Leu Pro Ala Gly Arg Lys Gln Cys Phe Tyr Gln 
        35                  40                  45              


Ser Ala Pro Ala Asn Ala Ser Leu Glu Thr Glu Tyr Gln Val Ile Gly 
    50                  55                  60                  


Gly Ala Gly Leu Asp Val Asp Phe Thr Leu Glu Ser Pro Gln Gly Val 
65                  70                  75                  80  


Leu Leu Val Ser Glu Ser Arg Lys Ala Asp Gly Val His Thr Val Glu 
                85                  90                  95      


Pro Thr Glu Ala Gly Asp Tyr Lys Leu Cys Phe Asp Asn Ser Phe Ser 
            100                 105                 110         


Thr Ile Ser Glu Lys Leu Val Phe Phe Glu Leu Ile Phe Asp Ser Leu 
        115                 120                 125             


Gln Asp Asp Glu Glu Val Glu Gly Trp Ala Glu Ala Val Glu Pro Glu 
    130                 135                 140                 


Glu Met Leu Asp Val Lys Met Glu Asp Ile Lys Glu Ser Ile Glu Thr 
145                 150                 155                 160 


Met Arg Thr Arg Leu Glu Arg Ser Ile Gln Met Leu Thr Leu Leu Arg 
                165                 170                 175     


Ala Phe Glu Ala Arg Asp Arg Asn Leu Gln Glu Gly Asn Leu Glu Arg 
            180                 185                 190         


Val Asn Phe Trp Ser Ala Val Asn Val Ala Val Leu Leu Leu Val Ala 
        195                 200                 205             


Val Leu Gln Val Cys Thr Leu Lys Arg Phe Phe Gln Asp Lys Arg Pro 
    210                 215                 220                 


Val Pro Thr 
225         


<210>  3585
<211>  561
<212>  PRT
<213>  Homo sapiens

<400>  3585

Met Ser Thr Glu Arg Thr Ser Trp Thr Ser Leu Ser Thr Ile Gln Lys 
1               5                   10                  15      


Ile Ala Leu Gly Leu Gly Ile Pro Ala Ser Ala Thr Val Ala Tyr Ile 
            20                  25                  30          


Leu Tyr Arg Arg Tyr Arg Glu Ser Arg Glu Glu Arg Leu Thr Phe Val 
        35                  40                  45              


Gly Glu Asp Asp Ile Glu Ile Glu Met Arg Val Pro Gln Glu Ala Val 
    50                  55                  60                  


Lys Leu Ile Ile Gly Arg Gln Gly Ala Asn Ile Lys Gln Leu Arg Lys 
65                  70                  75                  80  


Gln Thr Gly Ala Arg Ile Asp Val Asp Thr Glu Asp Val Gly Asp Glu 
                85                  90                  95      


Arg Val Leu Leu Ile Ser Gly Phe Pro Val Gln Val Cys Lys Ala Lys 
            100                 105                 110         


Ala Ala Ile His Gln Ile Leu Thr Glu Asn Thr Pro Val Ser Glu Gln 
        115                 120                 125             


Leu Ser Val Pro Gln Arg Ser Val Gly Arg Ile Ile Gly Arg Gly Gly 
    130                 135                 140                 


Glu Thr Ile Arg Ser Ile Cys Lys Ala Ser Gly Ala Lys Ile Thr Cys 
145                 150                 155                 160 


Asp Lys Glu Ser Glu Gly Thr Leu Leu Leu Ser Arg Leu Ile Lys Ile 
                165                 170                 175     


Ser Gly Thr Gln Lys Glu Val Ala Ala Ala Lys His Leu Ile Leu Glu 
            180                 185                 190         


Lys Val Ser Glu Asp Glu Glu Leu Arg Lys Arg Ile Ala His Ser Ala 
        195                 200                 205             


Glu Thr Arg Val Pro Arg Lys Gln Pro Ile Ser Val Arg Arg Glu Asp 
    210                 215                 220                 


Met Thr Glu Pro Gly Gly Ala Gly Glu Pro Ala Leu Trp Lys Asn Thr 
225                 230                 235                 240 


Ser Ser Ser Met Glu Pro Thr Ala Pro Leu Val Thr Pro Pro Pro Lys 
                245                 250                 255     


Gly Gly Gly Asp Met Ala Val Val Val Ser Lys Glu Gly Ser Trp Glu 
            260                 265                 270         


Lys Pro Ser Asp Asp Ser Phe Gln Lys Ser Glu Ala Gln Ala Ile Pro 
        275                 280                 285             


Glu Met Pro Met Phe Glu Ile Pro Ser Pro Asp Phe Ser Phe His Ala 
    290                 295                 300                 


Asp Glu Tyr Leu Glu Val Tyr Val Ser Ala Ser Glu His Pro Asn His 
305                 310                 315                 320 


Phe Trp Ile Gln Ile Val Gly Ser Arg Ser Leu Gln Leu Asp Lys Leu 
                325                 330                 335     


Val Asn Glu Met Thr Gln His Tyr Glu Asn Ser Val Pro Glu Asp Leu 
            340                 345                 350         


Thr Val His Val Gly Asp Ile Val Ala Ala Pro Leu Pro Thr Asn Gly 
        355                 360                 365             


Ser Trp Tyr Arg Ala Arg Val Leu Gly Thr Leu Glu Asn Gly Asn Leu 
    370                 375                 380                 


Asp Leu Tyr Phe Val Asp Phe Gly Asp Asn Gly Asp Cys Pro Leu Lys 
385                 390                 395                 400 


Asp Leu Arg Ala Leu Arg Ser Asp Phe Leu Ser Leu Pro Phe Gln Ala 
                405                 410                 415     


Ile Glu Cys Ser Leu Ala Arg Ile Ala Pro Ser Gly Asp Gln Trp Glu 
            420                 425                 430         


Glu Glu Ala Leu Asp Glu Phe Asp Arg Leu Thr His Cys Ala Asp Trp 
        435                 440                 445             


Lys Pro Leu Val Ala Lys Ile Ser Ser Tyr Val Gln Thr Gly Ile Ser 
    450                 455                 460                 


Thr Trp Pro Lys Ile Tyr Leu Tyr Asp Thr Ser Asn Gly Lys Lys Leu 
465                 470                 475                 480 


Asp Ile Gly Leu Glu Leu Val His Lys Gly Tyr Ala Ile Glu Leu Pro 
                485                 490                 495     


Glu Asp Ile Glu Glu Asn Arg Ala Val Pro Asp Met Leu Lys Asp Met 
            500                 505                 510         


Ala Thr Glu Thr Asp Ala Ser Leu Ser Thr Leu Leu Thr Glu Thr Lys 
        515                 520                 525             


Lys Ser Ser Gly Glu Ile Thr His Thr Leu Ser Cys Leu Ser Leu Ser 
    530                 535                 540                 


Glu Ala Ala Ser Met Ser Gly Asp Asp Asn Leu Glu Asp Asp Tyr Leu 
545                 550                 555                 560 


Leu 
    


<210>  3586
<211>  631
<212>  PRT
<213>  Homo sapiens

<400>  3586

Met Thr Pro Ala Leu Thr Ala Leu Leu Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr Arg Met Gln Ala Gly Pro Phe Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Ser Trp Gly Ser Pro Val Thr Ile Trp 
        35                  40                  45              


Cys Gln Gly Ser Leu Glu Ala Gln Glu Tyr Gln Leu Asp Lys Glu Gly 
    50                  55                  60                  


Ser Pro Glu Pro Trp Asp Arg Asn Asn Pro Leu Glu Pro Lys Asn Lys 
65                  70                  75                  80  


Ala Arg Phe Ser Ile Pro Ser Met Thr Gln His His Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys His Tyr Tyr Ser Ser Ala Gly Trp Ser Glu Pro Ser Asp Pro 
            100                 105                 110         


Leu Glu Leu Val Met Thr Gly Phe Tyr Asn Lys Pro Thr Leu Ser Ala 
        115                 120                 125             


Leu Pro Ser Pro Val Val Ala Ser Gly Gly Asn Met Thr Leu Arg Cys 
    130                 135                 140                 


Gly Ser Gln Lys Gly Tyr His His Phe Val Leu Met Lys Glu Gly Glu 
145                 150                 155                 160 


His Gln Leu Pro Arg Thr Leu Asp Ser Gln Gln Leu His Ser Gly Gly 
                165                 170                 175     


Phe Gln Ala Leu Phe Pro Val Gly Pro Val Thr Pro Ser His Arg Trp 
            180                 185                 190         


Arg Phe Thr Cys Tyr Tyr Tyr Tyr Thr Asn Thr Pro Trp Val Trp Ser 
        195                 200                 205             


His Pro Ser Asp Pro Leu Glu Ile Leu Pro Ser Gly Val Ser Arg Lys 
    210                 215                 220                 


Pro Ser Leu Leu Thr Leu Gln Gly Pro Val Leu Ala Pro Gly Gln Ser 
225                 230                 235                 240 


Leu Thr Leu Gln Cys Gly Ser Asp Val Gly Tyr Asp Arg Phe Val Leu 
                245                 250                 255     


Tyr Lys Glu Gly Glu Arg Asp Phe Leu Gln Arg Pro Gly Gln Gln Pro 
            260                 265                 270         


Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg 
        275                 280                 285             


Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser 
    290                 295                 300                 


Glu Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln 
305                 310                 315                 320 


Ile Tyr Asp Thr Val Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Ala 
                325                 330                 335     


Ser Gly Glu Asn Met Thr Leu Leu Cys Gln Ser Arg Gly Tyr Phe Asp 
            340                 345                 350         


Thr Phe Leu Leu Thr Lys Glu Gly Ala Ala His Pro Pro Leu Arg Leu 
        355                 360                 365             


Arg Ser Met Tyr Gly Ala His Lys Tyr Gln Ala Glu Phe Pro Met Ser 
    370                 375                 380                 


Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Arg 
385                 390                 395                 400 


Ser Ser Asn Pro His Leu Leu Ser Phe Pro Ser Glu Pro Leu Glu Leu 
                405                 410                 415     


Met Val Ser Gly His Ser Gly Gly Ser Ser Leu Pro Pro Thr Gly Pro 
            420                 425                 430         


Pro Ser Thr Pro Gly Leu Gly Arg Tyr Leu Glu Val Leu Ile Gly Val 
        435                 440                 445             


Ser Val Ala Phe Val Leu Leu Leu Phe Leu Leu Leu Phe Leu Leu Leu 
    450                 455                 460                 


Leu Arg Gln Arg His Ser Lys His Arg Thr Ser Asp Gln Arg Lys Thr 
465                 470                 475                 480 


Asp Phe Gln Arg Pro Ala Gly Ala Ala Glu Thr Glu Pro Lys Asp Arg 
                485                 490                 495     


Gly Leu Leu Arg Arg Ser Ser Pro Ala Ala Asp Val Gln Glu Glu Asn 
            500                 505                 510         


Leu Tyr Ala Ala Val Lys Asp Thr Gln Ser Glu Asp Arg Val Glu Leu 
        515                 520                 525             


Asp Ser Gln Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr Ala 
    530                 535                 540                 


Pro Val Lys His Ser Ser Pro Arg Arg Glu Met Ala Ser Pro Pro Ser 
545                 550                 555                 560 


Ser Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Val Glu Glu 
                565                 570                 575     


Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Ser Gln Asp 
            580                 585                 590         


Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Lys Ala Thr 
        595                 600                 605             


Glu Pro Pro Pro Ser Gln Glu Gly Glu Pro Pro Ala Glu Pro Ser Ile 
    610                 615                 620                 


Tyr Ala Thr Leu Ala Ile His 
625                 630     


<210>  3587
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  3587

Met Gln Met Ser Tyr Ala Ile Arg Cys Ala Phe Tyr Gln Leu Leu Leu 
1               5                   10                  15      


Ala Ala Leu Met Leu Val Ala Met Leu Gln Leu Leu Tyr Leu Ser Leu 
            20                  25                  30          


Leu Ser Gly Leu His Gly Gln Glu Glu Gln Asp Gln Tyr Phe Glu Phe 
        35                  40                  45              


Phe Pro Pro Ser Pro Arg Ser Val Asp Gln Val Lys Ala Gln Leu Arg 
    50                  55                  60                  


Thr Ala Leu Ala Ser Gly Gly Val Leu Asp Ala Ser Gly Asp Tyr Arg 
65                  70                  75                  80  


Val Tyr Arg Gly Leu Leu Lys Thr Thr Met Asp Pro Asn Asp Val Ile 
                85                  90                  95      


Leu Ala Thr His Ala Ser Val Asp Asn Leu Leu His Leu Ser Gly Leu 
            100                 105                 110         


Leu Glu Arg Trp Glu Gly Pro Leu Ser Val Ser Val Phe Ala Ala Thr 
        115                 120                 125             


Lys Glu Glu Ala Gln Leu Ala Thr Val Leu Ala Tyr Ala Leu Ser Ser 
    130                 135                 140                 


His Cys Pro Asp Met Arg Ala Arg Val Ala Met His Leu Val Cys Pro 
145                 150                 155                 160 


Ser Arg Tyr Glu Ala Ala Val Pro Asp Pro Arg Glu Pro Gly Glu Phe 
                165                 170                 175     


Ala Leu Leu Arg Ser Cys Gln Glu Val Phe Asp Lys Leu Ala Arg Val 
            180                 185                 190         


Ala Gln Pro Gly Ile Asn Tyr Ala Leu Gly Thr Asn Val Ser Tyr Pro 
        195                 200                 205             


Asn Asn Leu Leu Arg Asn Leu Ala Arg Glu Gly Ala Asn Tyr Ala Leu 
    210                 215                 220                 


Val Ile Asp Val Asp Met Val Pro Ser Glu Gly Leu Trp Arg Gly Leu 
225                 230                 235                 240 


Arg Glu Met Leu Asp Gln Ser Asn Gln Trp Gly Gly Thr Ala Leu Val 
                245                 250                 255     


Val Pro Ala Phe Glu Ile Arg Arg Ala Arg Arg Met Pro Met Asn Lys 
            260                 265                 270         


Asn Glu Leu Val Gln Leu Tyr Gln Val Gly Glu Val Arg Pro Phe Tyr 
        275                 280                 285             


Tyr Gly Leu Cys Thr Pro Cys Gln Ala Pro Thr Asn Tyr Ser Arg Trp 
    290                 295                 300                 


Val Asn Leu Pro Glu Glu Ser Leu Leu Arg Pro Ala Tyr Val Val Pro 
305                 310                 315                 320 


Trp Gln Asp Pro Trp Glu Pro Phe Tyr Val Ala Gly Gly Lys Val Pro 
                325                 330                 335     


Thr Phe Asp Glu Arg Phe Arg Gln Tyr Gly Phe Asn Arg Ile Ser Gln 
            340                 345                 350         


Ala Cys Glu Leu His Val Ala Gly Phe Asp Phe Glu Val Leu Asn Glu 
        355                 360                 365             


Gly Phe Leu Val His Lys Gly Phe Lys Glu Ala Leu Lys Phe His Pro 
    370                 375                 380                 


Gln Lys Glu Ala Glu Asn Gln His Asn Lys Ile Leu Tyr Arg Gln Phe 
385                 390                 395                 400 


Lys Gln Glu Leu Lys Ala Lys Tyr Pro Asn Ser Pro Arg Arg Cys 
                405                 410                 415 


<210>  3588
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  3588

Met Gln Met Ser Tyr Ala Ile Arg Cys Ala Phe Tyr Gln Leu Leu Leu 
1               5                   10                  15      


Ala Ala Leu Met Leu Val Ala Met Leu Gln Leu Leu Tyr Leu Ser Leu 
            20                  25                  30          


Leu Ser Gly Leu His Gly Gln Glu Glu Gln Asp Gln Tyr Phe Glu Phe 
        35                  40                  45              


Phe Pro Pro Ser Pro Arg Ser Val Asp Gln Val Lys Ala Gln Leu Arg 
    50                  55                  60                  


Thr Ala Leu Ala Ser Gly Gly Val Leu Asp Ala Ser Gly Asp Tyr Arg 
65                  70                  75                  80  


Val Tyr Arg Gly Leu Leu Lys Thr Thr Met Asp Pro Asn Asp Val Ile 
                85                  90                  95      


Leu Ala Thr His Ala Ser Val Asp Asn Leu Leu His Leu Ser Gly Leu 
            100                 105                 110         


Leu Glu Arg Trp Glu Gly Pro Leu Ser Val Ser Val Phe Ala Ala Thr 
        115                 120                 125             


Lys Glu Glu Ala Gln Leu Ala Thr Val Leu Ala Tyr Ala Leu Ser Ser 
    130                 135                 140                 


His Cys Pro Asp Met Arg Ala Arg Val Ala Met His Leu Val Cys Pro 
145                 150                 155                 160 


Ser Arg Tyr Glu Ala Ala Val Pro Asp Pro Arg Glu Pro Gly Glu Phe 
                165                 170                 175     


Ala Leu Leu Arg Ser Cys Gln Glu Val Phe Asp Lys Leu Ala Arg Val 
            180                 185                 190         


Ala Gln Pro Gly Ile Asn Tyr Ala Leu Gly Thr Asn Val Ser Tyr Pro 
        195                 200                 205             


Asn Asn Leu Leu Arg Asn Leu Ala Arg Glu Gly Ala Asn Tyr Ala Leu 
    210                 215                 220                 


Val Ile Asp Val Asp Met Val Pro Ser Glu Gly Leu Trp Arg Gly Leu 
225                 230                 235                 240 


Arg Glu Met Leu Asp Gln Ser Asn Gln Trp Gly Gly Thr Ala Leu Val 
                245                 250                 255     


Val Pro Ala Phe Glu Ile Arg Arg Ala Arg Arg Met Pro Met Asn Lys 
            260                 265                 270         


Asn Glu Leu Val Gln Leu Tyr Gln Val Gly Glu Val Arg Pro Phe Tyr 
        275                 280                 285             


Tyr Gly Leu Cys Thr Pro Cys Gln Ala Pro Thr Asn Tyr Ser Arg Trp 
    290                 295                 300                 


Val Asn Leu Pro Glu Glu Ser Leu Leu Arg Pro Ala Tyr Val Val Pro 
305                 310                 315                 320 


Trp Gln Asp Pro Trp Glu Pro Phe Tyr Val Ala Gly Gly Lys Val Pro 
                325                 330                 335     


Thr Phe Asp Glu Arg Phe Arg Gln Tyr Gly Phe Asn Arg Ile Ser Gln 
            340                 345                 350         


Ala Cys Glu Leu His Val Ala Gly Phe Asp Phe Glu Val Leu Asn Glu 
        355                 360                 365             


Gly Phe Leu Val His Lys Gly Phe Lys Glu Ala Leu Lys Phe His Pro 
    370                 375                 380                 


Gln Lys Glu Ala Glu Asn Gln His Asn Lys Ile Leu Tyr Arg Gln Phe 
385                 390                 395                 400 


Lys Gln Glu Leu Lys Ala Lys Tyr Pro Asn Ser Pro Arg Arg Cys 
                405                 410                 415 


<210>  3589
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  3589

Met Gly Leu Ser Asn Ile Leu Phe Val Met Ala Phe Leu Leu Ser Gly 
1               5                   10                  15      


Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu 
            20                  25                  30          


Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val 
        35                  40                  45              


Val Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu 
    50                  55                  60                  


Gly Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr 
65                  70                  75                  80  


Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile 
                85                  90                  95      


Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr 
            100                 105                 110         


Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
        115                 120                 125             


Asn Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
    130                 135                 140                 


Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro 
145                 150                 155                 160 


Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr 
                165                 170                 175     


Asp Gly Ile Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp 
            180                 185                 190         


Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met 
        195                 200                 205             


Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser 
    210                 215                 220                 


Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile 
225                 230                 235                 240 


Pro Trp Ile Thr Ala Val Leu Pro Thr Val Ile Ile Cys Val Met Val 
                245                 250                 255     


Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys Lys Lys Arg Pro Arg Asn 
            260                 265                 270         


Ser Tyr Lys Cys Gly Thr Asn Thr Met Glu Arg Glu Glu Ser Glu Gln 
        275                 280                 285             


Thr Lys Lys Arg Glu Lys Ile His Ile Pro Glu Arg Ser Asp Glu Ala 
    290                 295                 300                 


Gln Arg Val Phe Lys Ser Ser Lys Thr Ser Ser Cys Asp Lys Ser Asp 
305                 310                 315                 320 


Thr Cys Phe 
            


<210>  3590
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  3590

Met Gly Ser Pro Ser Ala Cys Pro Tyr Arg Val Cys Ile Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Leu Pro Asn 
            20                  25                  30          


Ser Ala Gln Thr Asn Ile Asp Val Val Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Val Val His Asn Glu Ser Gln Asn Leu Tyr Gly 
    50                  55                  60                  


Tyr Asn Trp Tyr Lys Gly Glu Arg Val His Ala Asn Tyr Arg Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Lys Asn Ile Ser Gln Glu Asn Ala Pro Gly Pro Ala His 
                85                  90                  95      


Asn Gly Arg Glu Thr Ile Tyr Pro Asn Gly Thr Leu Leu Ile Gln Asn 
            100                 105                 110         


Val Thr His Asn Asp Ala Gly Ile Tyr Thr Leu His Val Ile Lys Glu 
        115                 120                 125             


Asn Leu Val Asn Glu Glu Val Thr Arg Gln Phe Tyr Val Phe Ser Glu 
    130                 135                 140                 


Pro Pro Lys Pro Ser Ile Thr Ser Asn Asn Phe Asn Pro Val Glu Asn 
145                 150                 155                 160 


Lys Asp Ile Val Val Leu Thr Cys Gln Pro Glu Thr Gln Asn Thr Thr 
                165                 170                 175     


Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Leu Val Ser Pro Arg Leu 
            180                 185                 190         


Leu Leu Ser Thr Asp Asn Arg Thr Leu Val Leu Leu Ser Ala Thr Lys 
        195                 200                 205             


Asn Asp Ile Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Gly Ala 
    210                 215                 220                 


Ser Arg Ser Asp Pro Val Thr Leu Asn Val Arg Tyr Glu Ser Val Gln 
225                 230                 235                 240 


Ala Ser Ser Pro Asp Leu Ser Ala Gly Thr Ala Val Ser Ile Met Ile 
                245                 250                 255     


Gly Val Leu Ala Gly Met Ala Leu Ile 
            260                 265 


<210>  3591
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  3591

Met Ile Pro Thr Phe Thr Ala Leu Leu Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Met Gln Ala Gly Pro Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Ser Trp Gly Asn Ser Val Thr Ile Trp 
        35                  40                  45              


Cys Gln Gly Thr Leu Glu Ala Arg Glu Tyr Arg Leu Asp Lys Glu Glu 
    50                  55                  60                  


Ser Pro Ala Pro Trp Asp Arg Gln Asn Pro Leu Glu Pro Lys Asn Lys 
65                  70                  75                  80  


Ala Arg Phe Ser Ile Pro Ser Met Thr Glu Asp Tyr Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys Tyr Tyr Arg Ser Pro Val Gly Trp Ser Gln Pro Ser Asp Pro 
            100                 105                 110         


Leu Glu Leu Val Met Thr Gly Ala Tyr Ser Lys Pro Thr Leu Ser Ala 
        115                 120                 125             


Leu Pro Ser Pro Leu Val Thr Ser Gly Lys Ser Val Thr Leu Leu Cys 
    130                 135                 140                 


Gln Ser Arg Ser Pro Met Asp Thr Phe Leu Leu Ile Lys Glu Arg Ala 
145                 150                 155                 160 


Ala His Pro Leu Leu His Leu Arg Ser Glu His Gly Ala Gln Gln His 
                165                 170                 175     


Gln Ala Glu Phe Pro Met Ser Pro Val Thr Ser Val His Gly Gly Thr 
            180                 185                 190         


Tyr Arg Cys Phe Ser Ser His Gly Phe Ser His Tyr Leu Leu Ser His 
        195                 200                 205             


Pro Ser Asp Pro Leu Glu Leu Ile Val Ser Gly Ser Leu Glu Gly Pro 
    210                 215                 220                 


Arg Pro Ser Pro Thr Arg Ser Val Ser Thr Ala Ala Gly Pro Glu Asp 
225                 230                 235                 240 


Gln Pro Leu Met Pro Thr Gly Ser Val Pro His Ser Gly Leu Arg Arg 
                245                 250                 255     


His Trp Glu Val Leu Ile Gly Val Leu Val Val Ser Ile Leu Leu Leu 
            260                 265                 270         


Ser Leu Leu Leu Phe Leu Leu Leu Gln His Trp Arg Gln Gly Lys His 
        275                 280                 285             


Arg Thr Leu Ala Gln Arg Gln Ala Asp Phe Gln Arg Pro Pro Gly Ala 
    290                 295                 300                 


Ala Glu Pro Glu Pro Lys Asp Gly Gly Leu Gln Arg Arg Ser Ser Pro 
305                 310                 315                 320 


Ala Ala Asp Val Gln Gly Glu Asn Phe Cys Ala Ala Val Lys Asn Thr 
                325                 330                 335     


Gln Pro Glu Asp Gly Val Glu Met Asp Thr Arg Gln Ser Pro His Asp 
            340                 345                 350         


Glu Asp Pro Gln Ala Val Thr Tyr Ala Lys Val Lys His Ser Arg Pro 
        355                 360                 365             


Arg Arg Glu Met Ala Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu 
    370                 375                 380                 


Asp Thr Lys Asp Arg Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu 
385                 390                 395                 400 


Ala Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Arg Leu His 
                405                 410                 415     


Ser Phe Thr Leu Arg Gln Lys Ala Thr Glu Pro Pro Pro Ser Gln Glu 
            420                 425                 430         


Gly Ala Ser Pro Ala Glu Pro Ser Val Tyr Ala Thr Leu Ala Ile His 
        435                 440                 445             


<210>  3592
<211>  565
<212>  PRT
<213>  Homo sapiens

<400>  3592

Met Asn Tyr Glu Gly Ala Arg Ser Glu Arg Glu Asn His Ala Ala Asp 
1               5                   10                  15      


Asp Ser Glu Gly Gly Ala Leu Asp Met Cys Cys Ser Glu Arg Leu Pro 
            20                  25                  30          


Gly Leu Pro Gln Pro Ile Val Met Glu Ala Leu Asp Glu Ala Glu Gly 
        35                  40                  45              


Leu Gln Asp Ser Gln Arg Glu Met Pro Pro Pro Pro Pro Pro Ser Pro 
    50                  55                  60                  


Pro Ser Asp Pro Ala Gln Lys Pro Pro Pro Arg Gly Ala Gly Ser His 
65                  70                  75                  80  


Ser Leu Thr Val Arg Ser Ser Leu Cys Leu Phe Ala Ala Ser Gln Phe 
                85                  90                  95      


Leu Leu Ala Cys Gly Val Leu Trp Phe Ser Gly Tyr Gly His Ile Trp 
            100                 105                 110         


Ser Gln Asn Ala Thr Asn Leu Val Ser Ser Leu Leu Thr Leu Leu Lys 
        115                 120                 125             


Gln Leu Glu Pro Thr Ala Trp Leu Asp Ser Gly Thr Trp Gly Val Pro 
    130                 135                 140                 


Ser Leu Leu Leu Val Phe Leu Ser Val Gly Leu Val Leu Val Thr Thr 
145                 150                 155                 160 


Leu Val Trp His Leu Leu Arg Thr Pro Pro Glu Pro Pro Thr Pro Leu 
                165                 170                 175     


Pro Pro Glu Asp Arg Arg Gln Ser Val Ser Arg Gln Pro Ser Phe Thr 
            180                 185                 190         


Tyr Ser Glu Trp Met Glu Glu Lys Ile Glu Asp Asp Phe Leu Asp Leu 
        195                 200                 205             


Asp Pro Val Pro Glu Thr Pro Val Phe Asp Cys Val Met Asp Ile Lys 
    210                 215                 220                 


Pro Glu Ala Asp Pro Thr Ser Leu Thr Val Lys Ser Met Gly Leu Gln 
225                 230                 235                 240 


Glu Arg Arg Gly Ser Asn Val Ser Leu Thr Leu Asp Met Cys Thr Pro 
                245                 250                 255     


Gly Cys Asn Glu Glu Gly Phe Gly Tyr Leu Met Ser Pro Arg Glu Glu 
            260                 265                 270         


Ser Ala Arg Glu Tyr Leu Leu Ser Ala Ser Arg Val Leu Gln Ala Glu 
        275                 280                 285             


Glu Leu His Glu Lys Ala Leu Asp Pro Phe Leu Leu Gln Ala Glu Phe 
    290                 295                 300                 


Phe Glu Ile Pro Met Asn Phe Val Asp Pro Lys Glu Tyr Asp Ile Pro 
305                 310                 315                 320 


Gly Leu Val Arg Lys Asn Arg Tyr Lys Thr Ile Leu Pro Asn Pro His 
                325                 330                 335     


Ser Arg Val Cys Leu Thr Ser Pro Asp Pro Asp Asp Pro Leu Ser Ser 
            340                 345                 350         


Tyr Ile Asn Ala Asn Tyr Ile Arg Gly Tyr Gly Gly Glu Glu Lys Val 
        355                 360                 365             


Tyr Ile Ala Thr Gln Gly Pro Ile Val Ser Thr Val Ala Asp Phe Trp 
    370                 375                 380                 


Arg Met Val Trp Gln Glu His Thr Pro Ile Ile Val Met Ile Thr Asn 
385                 390                 395                 400 


Ile Glu Glu Met Asn Glu Lys Cys Thr Glu Tyr Trp Pro Glu Glu Gln 
                405                 410                 415     


Val Ala Tyr Asp Gly Val Glu Ile Thr Val Gln Lys Val Ile His Thr 
            420                 425                 430         


Glu Asp Tyr Arg Leu Arg Leu Ile Ser Leu Lys Ser Gly Thr Glu Glu 
        435                 440                 445             


Arg Gly Leu Lys His Tyr Trp Phe Thr Ser Trp Pro Asp Gln Lys Thr 
    450                 455                 460                 


Pro Asp Arg Ala Pro Pro Leu Leu His Leu Val Arg Glu Val Glu Glu 
465                 470                 475                 480 


Ala Ala Gln Gln Glu Gly Pro His Cys Ala Pro Ile Ile Val His Cys 
                485                 490                 495     


Ser Ala Gly Ile Gly Arg Thr Gly Cys Phe Ile Ala Thr Ser Ile Cys 
            500                 505                 510         


Cys Gln Gln Leu Arg Gln Glu Gly Val Val Asp Ile Leu Lys Thr Thr 
        515                 520                 525             


Cys Gln Leu Arg Gln Asp Arg Gly Gly Met Ile Gln Thr Cys Glu Gln 
    530                 535                 540                 


Tyr Gln Phe Val His His Val Met Ser Leu Tyr Glu Lys Gln Leu Ser 
545                 550                 555                 560 


His Gln Ser Pro Glu 
                565 


<210>  3593
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  3593

Met Asp Leu Val Leu Arg Val Ala Asp Tyr Tyr Phe Phe Thr Pro Tyr 
1               5                   10                  15      


Val Tyr Pro Ala Thr Trp Pro Glu Asp Asp Ile Phe Arg Gln Ala Ile 
            20                  25                  30          


Ser Leu Leu Ile Val Thr Asn Val Gly Ala Tyr Ile Leu Tyr Phe Phe 
        35                  40                  45              


Cys Ala Thr Leu Ser Tyr Tyr Phe Val Phe Asp His Ala Leu Met Lys 
    50                  55                  60                  


His Pro Gln Phe Leu Lys Asn Gln Val Arg Arg Glu Ile Lys Phe Thr 
65                  70                  75                  80  


Val Gln Ala Leu Pro Trp Ile Ser Ile Leu Thr Val Ala Leu Phe Leu 
                85                  90                  95      


Leu Glu Ile Arg Gly Tyr Ser Lys Leu His Asp Asp Leu Gly Glu Phe 
            100                 105                 110         


Pro Tyr Gly Leu Phe Glu Leu Val Val Ser Ile Ile Ser Phe Leu Phe 
        115                 120                 125             


Phe Thr Asp Met Phe Ile Tyr Trp Ile His Arg Gly Leu His His Arg 
    130                 135                 140                 


Leu Val Tyr Lys Arg Leu His Lys Pro His His Ile Trp Lys Ile Pro 
145                 150                 155                 160 


Thr Pro Phe Ala Ser His Ala Phe His Pro Ile Asp Gly Phe Leu Gln 
                165                 170                 175     


Ser Leu Pro Tyr His Ile Tyr Pro Phe Ile Phe Pro Leu His Lys Val 
            180                 185                 190         


Val Tyr Leu Ser Leu Tyr Ile Leu Val Asn Ile Trp Thr Ile Ser Ile 
        195                 200                 205             


His Asp Gly Asp Phe Arg Val Pro Gln Ile Leu Gln Pro Phe Ile Asn 
    210                 215                 220                 


Gly Ser Ala His His Thr Asp His His Met Phe Phe Asp Tyr Asn Tyr 
225                 230                 235                 240 


Gly Gln Tyr Phe Thr Leu Trp Asp Arg Ile Gly Gly Ser Phe Lys Asn 
                245                 250                 255     


Pro Ser Ser Phe Glu Gly Lys Gly Pro Leu Ser Tyr Val Lys Glu Met 
            260                 265                 270         


Thr Glu Gly Lys Arg Ser Ser His Ser Gly Asn Gly Cys Lys Asn Glu 
        275                 280                 285             


Lys Leu Phe Asn Gly Glu Phe Thr Lys Thr Glu 
    290                 295                 


<210>  3594
<211>  1998
<212>  PRT
<213>  Homo sapiens

<400>  3594

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Gly 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Gly Thr 
            660                 665                 670         


Thr Thr Glu Thr Glu Met Arg Lys Arg Arg Ser Ser Ser Phe His Val 
        675                 680                 685             


Ser Met Asp Phe Leu Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser 
    690                 695                 700                 


Ile Ala Ser Ile Leu Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg 
705                 710                 715                 720 


Gln Lys Cys Pro Pro Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile 
                725                 730                 735     


Trp Asp Cys Ser Pro Tyr Trp Leu Lys Val Lys His Val Val Asn Leu 
            740                 745                 750         


Val Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val 
        755                 760                 765             


Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met Thr Asp His 
    770                 775                 780                 


Phe Asn Asn Val Leu Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe 
785                 790                 795                 800 


Thr Ala Glu Met Phe Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr 
                805                 810                 815     


Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser 
            820                 825                 830         


Leu Val Glu Leu Gly Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg 
        835                 840                 845             


Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr 
    850                 855                 860                 


Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly 
865                 870                 875                 880 


Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val 
                885                 890                 895     


Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile 
            900                 905                 910         


Ala Ser Asp Cys Gln Leu Pro Arg Trp His Met Asn Asp Phe Phe His 
        915                 920                 925             


Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr 
    930                 935                 940                 


Met Trp Asp Cys Met Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val 
945                 950                 955                 960 


Phe Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe 
                965                 970                 975     


Leu Ala Leu Leu Leu Ser Ser Phe Ser Ala Asp Asn Leu Ala Ala Thr 
            980                 985                 990         


Asp Asp Asp Asn Glu Met Asn Asn  Leu Gln Ile Ala Val  Asp Arg Met 
        995                 1000                 1005             


His Lys  Gly Val Ala Tyr Val  Lys Arg Lys Ile Tyr  Glu Phe Ile 
    1010                 1015                 1020             


Gln Gln  Ser Phe Ile Arg Lys  Gln Lys Ile Leu Asp  Glu Ile Lys 
    1025                 1030                 1035             


Pro Leu  Asp Asp Leu Asn Asn  Lys Lys Asp Ser Cys  Met Ser Asn 
    1040                 1045                 1050             


His Thr  Ala Glu Ile Gly Lys  Asp Leu Asp Tyr Leu  Lys Asp Val 
    1055                 1060                 1065             


Asn Gly  Thr Thr Ser Gly Ile  Gly Thr Gly Ser Ser  Val Glu Lys 
    1070                 1075                 1080             


Tyr Ile  Ile Asp Glu Ser Asp  Tyr Met Ser Phe Ile  Asn Asn Pro 
    1085                 1090                 1095             


Ser Leu  Thr Val Thr Val Pro  Ile Ala Val Gly Glu  Ser Asp Phe 
    1100                 1105                 1110             


Glu Asn  Leu Asn Thr Glu Asp  Phe Ser Ser Glu Ser  Asp Leu Glu 
    1115                 1120                 1125             


Glu Ser  Lys Glu Lys Leu Asn  Glu Ser Ser Ser Ser  Ser Glu Gly 
    1130                 1135                 1140             


Ser Thr  Val Asp Ile Gly Ala  Pro Val Glu Glu Gln  Pro Val Val 
    1145                 1150                 1155             


Glu Pro  Glu Glu Thr Leu Glu  Pro Glu Ala Cys Phe  Thr Glu Gly 
    1160                 1165                 1170             


Cys Val  Gln Arg Phe Lys Cys  Cys Gln Ile Asn Val  Glu Glu Gly 
    1175                 1180                 1185             


Arg Gly  Lys Gln Trp Trp Asn  Leu Arg Arg Thr Cys  Phe Arg Ile 
    1190                 1195                 1200             


Val Glu  His Asn Trp Phe Glu  Thr Phe Ile Val Phe  Met Ile Leu 
    1205                 1210                 1215             


Leu Ser  Ser Gly Ala Leu Ala  Phe Glu Asp Ile Tyr  Ile Asp Gln 
    1220                 1225                 1230             


Arg Lys  Thr Ile Lys Thr Met  Leu Glu Tyr Ala Asp  Lys Val Phe 
    1235                 1240                 1245             


Thr Tyr  Ile Phe Ile Leu Glu  Met Leu Leu Lys Trp  Val Ala Tyr 
    1250                 1255                 1260             


Gly Tyr  Gln Thr Tyr Phe Thr  Asn Ala Trp Cys Trp  Leu Asp Phe 
    1265                 1270                 1275             


Leu Ile  Val Asp Val Ser Leu  Val Ser Leu Thr Ala  Asn Ala Leu 
    1280                 1285                 1290             


Gly Tyr  Ser Glu Leu Gly Ala  Ile Lys Ser Leu Arg  Thr Leu Arg 
    1295                 1300                 1305             


Ala Leu  Arg Pro Leu Arg Ala  Leu Ser Arg Phe Glu  Gly Met Arg 
    1310                 1315                 1320             


Val Val  Val Asn Ala Leu Leu  Gly Ala Ile Pro Ser  Ile Met Asn 
    1325                 1330                 1335             


Val Leu  Leu Val Cys Leu Ile  Phe Trp Leu Ile Phe  Ser Ile Met 
    1340                 1345                 1350             


Gly Val  Asn Leu Phe Ala Gly  Lys Phe Tyr His Cys  Ile Asn Thr 
    1355                 1360                 1365             


Thr Thr  Gly Asp Arg Phe Asp  Ile Glu Asp Val Asn  Asn His Thr 
    1370                 1375                 1380             


Asp Cys  Leu Lys Leu Ile Glu  Arg Asn Glu Thr Ala  Arg Trp Lys 
    1385                 1390                 1395             


Asn Val  Lys Val Asn Phe Asp  Asn Val Gly Phe Gly  Tyr Leu Ser 
    1400                 1405                 1410             


Leu Leu  Gln Val Ala Thr Phe  Lys Gly Trp Met Asp  Ile Met Tyr 
    1415                 1420                 1425             


Ala Ala  Val Asp Ser Arg Asn  Val Glu Leu Gln Pro  Lys Tyr Glu 
    1430                 1435                 1440             


Glu Ser  Leu Tyr Met Tyr Leu  Tyr Phe Val Ile Phe  Ile Ile Phe 
    1445                 1450                 1455             


Gly Ser  Phe Phe Thr Leu Asn  Leu Phe Ile Gly Val  Ile Ile Asp 
    1460                 1465                 1470             


Asn Phe  Asn Gln Gln Lys Lys  Lys Phe Gly Gly Gln  Asp Ile Phe 
    1475                 1480                 1485             


Met Thr  Glu Glu Gln Lys Lys  Tyr Tyr Asn Ala Met  Lys Lys Leu 
    1490                 1495                 1500             


Gly Ser  Lys Lys Pro Gln Lys  Pro Ile Pro Arg Pro  Gly Asn Lys 
    1505                 1510                 1515             


Phe Gln  Gly Met Val Phe Asp  Phe Val Thr Arg Gln  Val Phe Asp 
    1520                 1525                 1530             


Ile Ser  Ile Met Ile Leu Ile  Cys Leu Asn Met Val  Thr Met Met 
    1535                 1540                 1545             


Val Glu  Thr Asp Asp Gln Ser  Glu Tyr Val Thr Thr  Ile Leu Ser 
    1550                 1555                 1560             


Arg Ile  Asn Leu Val Phe Ile  Val Leu Phe Thr Gly  Glu Cys Val 
    1565                 1570                 1575             


Leu Lys  Leu Ile Ser Leu Arg  His Tyr Tyr Phe Thr  Ile Gly Trp 
    1580                 1585                 1590             


Asn Ile  Phe Asp Phe Val Val  Val Ile Leu Ser Ile  Val Gly Met 
    1595                 1600                 1605             


Phe Leu  Ala Glu Leu Ile Glu  Lys Tyr Phe Val Ser  Pro Thr Leu 
    1610                 1615                 1620             


Phe Arg  Val Ile Arg Leu Ala  Arg Ile Gly Arg Ile  Leu Arg Leu 
    1625                 1630                 1635             


Ile Lys  Gly Ala Lys Gly Ile  Arg Thr Leu Leu Phe  Ala Leu Met 
    1640                 1645                 1650             


Met Ser  Leu Pro Ala Leu Phe  Asn Ile Gly Leu Leu  Leu Phe Leu 
    1655                 1660                 1665             


Val Met  Phe Ile Tyr Ala Ile  Phe Gly Met Ser Asn  Phe Ala Tyr 
    1670                 1675                 1680             


Val Lys  Arg Glu Val Gly Ile  Asp Asp Met Phe Asn  Phe Glu Thr 
    1685                 1690                 1695             


Phe Gly  Asn Ser Met Ile Cys  Leu Phe Gln Ile Thr  Thr Ser Ala 
    1700                 1705                 1710             


Gly Trp  Asp Gly Leu Leu Ala  Pro Ile Leu Asn Ser  Lys Pro Pro 
    1715                 1720                 1725             


Asp Cys  Asp Pro Asn Lys Val  Asn Pro Gly Ser Ser  Val Lys Gly 
    1730                 1735                 1740             


Asp Cys  Gly Asn Pro Ser Val  Gly Ile Phe Phe Phe  Val Ser Tyr 
    1745                 1750                 1755             


Ile Ile  Ile Ser Phe Leu Val  Val Val Asn Met Tyr  Ile Ala Val 
    1760                 1765                 1770             


Ile Leu  Glu Asn Phe Ser Val  Ala Thr Glu Glu Ser  Ala Glu Pro 
    1775                 1780                 1785             


Leu Ser  Glu Asp Asp Phe Glu  Met Phe Tyr Glu Val  Trp Glu Lys 
    1790                 1795                 1800             


Phe Asp  Pro Asp Ala Thr Gln  Phe Met Glu Phe Glu  Lys Leu Ser 
    1805                 1810                 1815             


Gln Phe  Ala Ala Ala Leu Glu  Pro Pro Leu Asn Leu  Pro Gln Pro 
    1820                 1825                 1830             


Asn Lys  Leu Gln Leu Ile Ala  Met Asp Leu Pro Met  Val Ser Gly 
    1835                 1840                 1845             


Asp Arg  Ile His Cys Leu Asp  Ile Leu Phe Ala Phe  Thr Lys Arg 
    1850                 1855                 1860             


Val Leu  Gly Glu Ser Gly Glu  Met Asp Ala Leu Arg  Ile Gln Met 
    1865                 1870                 1875             


Glu Glu  Arg Phe Met Ala Ser  Asn Pro Ser Lys Val  Ser Tyr Gln 
    1880                 1885                 1890             


Pro Ile  Thr Thr Thr Leu Lys  Arg Lys Gln Glu Glu  Val Ser Ala 
    1895                 1900                 1905             


Val Ile  Ile Gln Arg Ala Tyr  Arg Arg His Leu Leu  Lys Arg Thr 
    1910                 1915                 1920             


Val Lys  Gln Ala Ser Phe Thr  Tyr Asn Lys Asn Lys  Ile Lys Gly 
    1925                 1930                 1935             


Gly Ala  Asn Leu Leu Ile Lys  Glu Asp Met Ile Ile  Asp Arg Ile 
    1940                 1945                 1950             


Asn Glu  Asn Ser Ile Thr Glu  Lys Thr Asp Leu Thr  Met Ser Thr 
    1955                 1960                 1965             


Ala Ala  Cys Pro Pro Ser Tyr  Asp Arg Val Thr Lys  Pro Ile Val 
    1970                 1975                 1980             


Glu Lys  His Glu Gln Glu Gly  Lys Asp Glu Lys Ala  Lys Gly Lys 
    1985                 1990                 1995             


<210>  3595
<211>  2000
<212>  PRT
<213>  Homo sapiens

<400>  3595

Met Ala Gln Ala Leu Leu Val Pro Pro Gly Pro Glu Ser Phe Arg Leu 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Ala Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Lys Pro Lys Lys Glu Gln Asp Asn Asp Asp Glu Asn Lys 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Met Asn Lys Gly 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Leu Asn Pro Val Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Leu Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Ser Val Ile Val Met Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Ser Asp Ser Ala Phe Glu 
        275                 280                 285             


Thr Asn Thr Thr Ser Tyr Phe Asn Gly Thr Met Asp Ser Asn Gly Thr 
    290                 295                 300                 


Phe Val Asn Val Thr Met Ser Thr Phe Asn Trp Lys Asp Tyr Ile Gly 
305                 310                 315                 320 


Asp Asp Ser His Phe Tyr Val Leu Asp Gly Gln Lys Asp Pro Leu Leu 
                325                 330                 335     


Cys Gly Asn Gly Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile Cys 
            340                 345                 350         


Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr 
        355                 360                 365             


Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Tyr 
    370                 375                 380                 


Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr 
385                 390                 395                 400 


Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Val 
                405                 410                 415     


Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln 
            420                 425                 430         


Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met 
        435                 440                 445             


Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Val Ala Ala 
    450                 455                 460                 


Ala Ser Ala Ala Ser Arg Asp Phe Ser Gly Ile Gly Gly Leu Gly Glu 
465                 470                 475                 480 


Leu Leu Glu Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala 
                485                 490                 495     


Lys Glu Trp Arg Asn Arg Arg Lys Lys Arg Arg Gln Arg Glu His Leu 
            500                 505                 510         


Glu Gly Asn Asn Lys Gly Glu Arg Asp Ser Phe Pro Lys Ser Glu Ser 
        515                 520                 525             


Glu Asp Ser Val Lys Arg Ser Ser Phe Leu Phe Ser Met Asp Gly Asn 
    530                 535                 540                 


Arg Leu Thr Ser Asp Lys Lys Phe Cys Ser Pro His Gln Ser Leu Leu 
545                 550                 555                 560 


Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Lys Thr Ser 
                565                 570                 575     


Ile Phe Ser Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp 
            580                 585                 590         


Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Ser Glu Ser Arg Arg 
        595                 600                 605             


Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg Asn Ser Asn 
    610                 615                 620                 


Val Ser Gln Ala Ser Met Ser Ser Arg Met Val Pro Gly Leu Pro Ala 
625                 630                 635                 640 


Asn Gly Lys Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu 
                645                 650                 655     


Val Gly Gly Pro Ser Ala Leu Thr Ser Pro Thr Gly Gln Leu Pro Pro 
            660                 665                 670         


Glu Gly Thr Thr Thr Glu Thr Glu Val Arg Lys Arg Arg Leu Ser Ser 
        675                 680                 685             


Tyr Gln Ile Ser Met Glu Met Leu Glu Asp Ser Ser Gly Arg Gln Arg 
    690                 695                 700                 


Ala Val Ser Ile Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu 
705                 710                 715                 720 


Glu Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Arg Phe Ala Asn Val 
                725                 730                 735     


Phe Leu Ile Trp Asp Cys Cys Asp Ala Trp Leu Lys Val Lys His Leu 
            740                 745                 750         


Val Asn Leu Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile 
        755                 760                 765             


Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met 
    770                 775                 780                 


Thr Glu Gln Phe Ser Ser Val Leu Thr Val Gly Asn Leu Val Phe Thr 
785                 790                 795                 800 


Gly Ile Phe Thr Ala Glu Met Val Leu Lys Ile Ile Ala Met Asp Pro 
                805                 810                 815     


Tyr Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Ile Ile Val 
            820                 825                 830         


Ser Leu Ser Leu Met Glu Leu Gly Leu Ser Asn Val Glu Gly Leu Ser 
        835                 840                 845             


Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser 
    850                 855                 860                 


Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly 
865                 870                 875                 880 


Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe 
                885                 890                 895     


Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val 
            900                 905                 910         


Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg Trp His Met Asn Asp 
        915                 920                 925             


Phe Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp 
    930                 935                 940                 


Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys 
945                 950                 955                 960 


Leu Ile Val Phe Met Leu Val Met Val Ile Gly Asn Leu Val Val Leu 
                965                 970                 975     


Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu 
            980                 985                 990         


Ala Ala Thr Asp Asp Asp Asn Glu  Met Asn Asn Leu Gln  Ile Ala Val 
        995                 1000                 1005             


Gly Arg  Met Gln Lys Gly Ile  Asp Tyr Val Lys Asn  Lys Met Arg 
    1010                 1015                 1020             


Glu Cys  Phe Gln Lys Ala Phe  Phe Arg Lys Pro Lys  Val Ile Glu 
    1025                 1030                 1035             


Ile His  Glu Gly Asn Lys Ile  Asp Ser Cys Met Ser  Asn Asn Thr 
    1040                 1045                 1050             


Gly Ile  Glu Ile Ser Lys Glu  Leu Asn Tyr Leu Arg  Asp Gly Asn 
    1055                 1060                 1065             


Gly Thr  Thr Ser Gly Val Gly  Thr Gly Ser Ser Val  Glu Lys Tyr 
    1070                 1075                 1080             


Val Ile  Asp Glu Asn Asp Tyr  Met Ser Phe Ile Asn  Asn Pro Ser 
    1085                 1090                 1095             


Leu Thr  Val Thr Val Pro Ile  Ala Val Gly Glu Ser  Asp Phe Glu 
    1100                 1105                 1110             


Asn Leu  Asn Thr Glu Glu Phe  Ser Ser Glu Ser Glu  Leu Glu Glu 
    1115                 1120                 1125             


Ser Lys  Glu Lys Leu Asn Ala  Thr Ser Ser Ser Glu  Gly Ser Thr 
    1130                 1135                 1140             


Val Asp  Val Val Leu Pro Arg  Glu Gly Glu Gln Ala  Glu Thr Glu 
    1145                 1150                 1155             


Pro Glu  Glu Asp Leu Lys Pro  Glu Ala Cys Phe Thr  Glu Gly Cys 
    1160                 1165                 1170             


Ile Lys  Lys Phe Pro Phe Cys  Gln Val Ser Thr Glu  Glu Gly Lys 
    1175                 1180                 1185             


Gly Lys  Ile Trp Trp Asn Leu  Arg Lys Thr Cys Tyr  Ser Ile Val 
    1190                 1195                 1200             


Glu His  Asn Trp Phe Glu Thr  Phe Ile Val Phe Met  Ile Leu Leu 
    1205                 1210                 1215             


Ser Ser  Gly Ala Leu Ala Phe  Glu Asp Ile Tyr Ile  Glu Gln Arg 
    1220                 1225                 1230             


Lys Thr  Ile Lys Thr Met Leu  Glu Tyr Ala Asp Lys  Val Phe Thr 
    1235                 1240                 1245             


Tyr Ile  Phe Ile Leu Glu Met  Leu Leu Lys Trp Val  Ala Tyr Gly 
    1250                 1255                 1260             


Phe Gln  Thr Tyr Phe Thr Asn  Ala Trp Cys Trp Leu  Asp Phe Leu 
    1265                 1270                 1275             


Ile Val  Asp Val Ser Leu Val  Ser Leu Val Ala Asn  Ala Leu Gly 
    1280                 1285                 1290             


Tyr Ser  Glu Leu Gly Ala Ile  Lys Ser Leu Arg Thr  Leu Arg Ala 
    1295                 1300                 1305             


Leu Arg  Pro Leu Arg Ala Leu  Ser Arg Phe Glu Gly  Met Arg Val 
    1310                 1315                 1320             


Val Val  Asn Ala Leu Val Gly  Ala Ile Pro Ser Ile  Met Asn Val 
    1325                 1330                 1335             


Leu Leu  Val Cys Leu Ile Phe  Trp Leu Ile Phe Ser  Ile Met Gly 
    1340                 1345                 1350             


Val Asn  Leu Phe Ala Gly Lys  Phe Tyr His Cys Val  Asn Met Thr 
    1355                 1360                 1365             


Thr Gly  Asn Met Phe Asp Ile  Ser Asp Val Asn Asn  Leu Ser Asp 
    1370                 1375                 1380             


Cys Gln  Ala Leu Gly Lys Gln  Ala Arg Trp Lys Asn  Val Lys Val 
    1385                 1390                 1395             


Asn Phe  Asp Asn Val Gly Ala  Gly Tyr Leu Ala Leu  Leu Gln Val 
    1400                 1405                 1410             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1415                 1420                 1425             


Ser Arg  Asp Val Lys Leu Gln  Pro Val Tyr Glu Glu  Asn Leu Tyr 
    1430                 1435                 1440             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1445                 1450                 1455             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1460                 1465                 1470             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1475                 1480                 1485             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1490                 1495                 1500             


Pro Gln  Lys Pro Ile Pro Arg  Pro Ala Asn Lys Phe  Gln Gly Met 
    1505                 1510                 1515             


Val Phe  Asp Phe Val Thr Arg  Gln Val Phe Asp Ile  Ser Ile Met 
    1520                 1525                 1530             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1535                 1540                 1545             


Asp Gln  Gly Lys Tyr Met Thr  Leu Val Leu Ser Arg  Ile Asn Leu 
    1550                 1555                 1560             


Val Phe  Ile Val Leu Phe Thr  Gly Glu Phe Val Leu  Lys Leu Val 
    1565                 1570                 1575             


Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1580                 1585                 1590             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Met Phe  Leu Ala Glu 
    1595                 1600                 1605             


Met Ile  Glu Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Arg Val Ile 
    1610                 1615                 1620             


Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg Leu Ile  Lys Gly Ala 
    1625                 1630                 1635             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1640                 1645                 1650             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1655                 1660                 1665             


Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Lys Glu 
    1670                 1675                 1680             


Ala Gly  Ile Asp Asp Met Phe  Asn Phe Glu Thr Phe  Gly Asn Ser 
    1685                 1690                 1695             


Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1700                 1705                 1710             


Leu Leu  Ala Pro Ile Leu Asn  Ser Ala Pro Pro Asp  Cys Asp Pro 
    1715                 1720                 1725             


Asp Thr  Ile His Pro Gly Ser  Ser Val Lys Gly Asp  Cys Gly Asn 
    1730                 1735                 1740             


Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser 
    1745                 1750                 1755             


Phe Leu  Val Val Val Asn Met  Tyr Ile Ala Val Ile  Leu Glu Asn 
    1760                 1765                 1770             


Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu Pro Leu  Ser Glu Asp 
    1775                 1780                 1785             


Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu Lys Phe  Asp Pro Asp 
    1790                 1795                 1800             


Ala Thr  Gln Phe Ile Glu Phe  Ser Lys Leu Ser Asp  Phe Ala Ala 
    1805                 1810                 1815             


Ala Leu  Asp Pro Pro Leu Leu  Ile Ala Lys Pro Asn  Lys Val Gln 
    1820                 1825                 1830             


Leu Ile  Ala Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1835                 1840                 1845             


Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1850                 1855                 1860             


Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln Met Glu  Asp Arg Phe 
    1865                 1870                 1875             


Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr Glu Pro  Ile Thr Thr 
    1880                 1885                 1890             


Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser Ala Ala  Ile Ile Gln 
    1895                 1900                 1905             


Arg Asn  Phe Arg Cys Tyr Leu  Leu Lys Gln Arg Leu  Lys Asn Ile 
    1910                 1915                 1920             


Ser Ser  Asn Tyr Asn Lys Glu  Ala Ile Lys Gly Arg  Ile Asp Leu 
    1925                 1930                 1935             


Pro Ile  Lys Gln Asp Met Ile  Ile Asp Lys Leu Asn  Gly Asn Ser 
    1940                 1945                 1950             


Thr Pro  Glu Lys Thr Asp Gly  Ser Ser Ser Thr Thr  Ser Pro Pro 
    1955                 1960                 1965             


Ser Tyr  Asp Ser Val Thr Lys  Pro Asp Lys Glu Lys  Phe Glu Lys 
    1970                 1975                 1980             


Asp Lys  Pro Glu Lys Glu Ser  Lys Gly Lys Glu Val  Arg Glu Asn 
    1985                 1990                 1995             


Gln Lys  
    2000 


<210>  3596
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  3596

Met Lys Cys Ser Leu Arg Val Trp Phe Leu Ser Val Ala Phe Leu Leu 
1               5                   10                  15      


Val Phe Ile Met Ser Leu Leu Phe Thr Tyr Ser His His Ser Met Ala 
            20                  25                  30          


Thr Leu Pro Tyr Leu Asp Ser Gly Ala Leu Asp Gly Thr His Arg Val 
        35                  40                  45              


Lys Leu Val Pro Gly Tyr Ala Gly Leu Gln Arg Leu Ser Lys Glu Arg 
    50                  55                  60                  


Leu Ser Gly Lys Ser Cys Ala Cys Arg Arg Cys Met Gly Asp Ala Gly 
65                  70                  75                  80  


Ala Ser Asp Trp Phe Asp Ser His Phe Asp Gly Asn Ile Ser Pro Val 
                85                  90                  95      


Trp Thr Arg Glu Asn Met Asp Leu Pro Pro Asp Val Gln Arg Trp Trp 
            100                 105                 110         


Met Met Leu Gln Pro Gln Phe Lys Ser His Asn Thr Asn Glu Val Leu 
        115                 120                 125             


Glu Lys Leu Phe Gln Ile Val Pro Gly Glu Asn Pro Tyr Arg Phe Arg 
    130                 135                 140                 


Asp Pro His Gln Cys Arg Arg Cys Ala Val Val Gly Asn Ser Gly Asn 
145                 150                 155                 160 


Leu Arg Gly Ser Gly Tyr Gly Gln Asp Val Asp Gly His Asn Phe Ile 
                165                 170                 175     


Met Arg Met Asn Gln Ala Pro Thr Val Gly Phe Glu Gln Asp Val Gly 
            180                 185                 190         


Ser Arg Thr Thr His His Phe Met Tyr Pro Glu Ser Ala Lys Asn Leu 
        195                 200                 205             


Pro Ala Asn Val Ser Phe Val Leu Val Pro Phe Lys Val Leu Asp Leu 
    210                 215                 220                 


Leu Trp Ile Ala Ser Ala Leu Ser Thr Gly Gln Ile Arg Phe Thr Tyr 
225                 230                 235                 240 


Ala Pro Val Lys Ser Phe Leu Arg Val Asp Lys Glu Lys Val Gln Ile 
                245                 250                 255     


Tyr Asn Pro Ala Phe Phe Lys Tyr Ile His Asp Arg Trp Thr Glu His 
            260                 265                 270         


His Gly Arg Tyr Pro Ser Thr Gly Met Leu Val Leu Phe Phe Ala Leu 
        275                 280                 285             


His Val Cys Asp Glu Val Asn Val Tyr Gly Phe Gly Ala Asp Ser Arg 
    290                 295                 300                 


Gly Asn Trp His His Tyr Trp Glu Asn Asn Arg Tyr Ala Gly Glu Phe 
305                 310                 315                 320 


Arg Lys Thr Gly Val His Asp Ala Asp Phe Glu Ala His Ile Ile Asp 
                325                 330                 335     


Met Leu Ala Lys Ala Ser Lys Ile Glu Val Tyr Arg Gly Asn 
            340                 345                 350 


<210>  3597
<211>  661
<212>  PRT
<213>  Homo sapiens

<400>  3597

Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 
1               5                   10                  15      


Ala Leu Leu Ala Val Gly Ala Thr Lys Val Pro Arg Asn Gln Asp Trp 
            20                  25                  30          


Leu Gly Val Ser Arg Gln Leu Arg Thr Lys Ala Trp Asn Arg Gln Leu 
        35                  40                  45              


Tyr Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp Cys Trp Arg Gly Gly 
    50                  55                  60                  


Gln Val Ser Leu Lys Val Ser Asn Asp Gly Pro Thr Leu Ile Gly Ala 
65                  70                  75                  80  


Asn Ala Ser Phe Ser Ile Ala Leu Asn Phe Pro Gly Ser Gln Lys Val 
                85                  90                  95      


Leu Pro Asp Gly Gln Val Ile Trp Val Asn Asn Thr Ile Ile Asn Gly 
            100                 105                 110         


Ser Gln Val Trp Gly Gly Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp 
        115                 120                 125             


Ala Cys Ile Phe Pro Asp Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser 
    130                 135                 140                 


Gln Lys Arg Ser Phe Val Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp 
145                 150                 155                 160 


Gln Val Leu Gly Gly Pro Val Ser Gly Leu Ser Ile Gly Thr Gly Arg 
                165                 170                 175     


Ala Met Leu Gly Thr His Thr Met Glu Val Thr Val Tyr His Arg Arg 
            180                 185                 190         


Gly Ser Arg Ser Tyr Val Pro Leu Ala His Ser Ser Ser Ala Phe Thr 
        195                 200                 205             


Ile Thr Asp Gln Val Pro Phe Ser Val Ser Val Ser Gln Leu Arg Ala 
    210                 215                 220                 


Leu Asp Gly Gly Asn Lys His Phe Leu Arg Asn Gln Pro Leu Thr Phe 
225                 230                 235                 240 


Ala Leu Gln Leu His Asp Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu 
                245                 250                 255     


Ser Tyr Thr Trp Asp Phe Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg 
            260                 265                 270         


Ala Leu Val Val Thr His Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala 
        275                 280                 285             


Gln Val Val Leu Gln Ala Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser 
    290                 295                 300                 


Pro Val Pro Gly Thr Thr Asp Gly His Arg Pro Thr Ala Glu Ala Pro 
305                 310                 315                 320 


Asn Thr Thr Ala Gly Gln Val Pro Thr Thr Glu Val Val Gly Thr Thr 
                325                 330                 335     


Pro Gly Gln Ala Pro Thr Ala Glu Pro Ser Gly Thr Thr Ser Val Gln 
            340                 345                 350         


Val Pro Thr Thr Glu Val Ile Ser Thr Ala Pro Val Gln Met Pro Thr 
        355                 360                 365             


Ala Glu Ser Thr Gly Met Thr Pro Glu Lys Val Pro Val Ser Glu Val 
    370                 375                 380                 


Met Gly Thr Thr Leu Ala Glu Met Ser Thr Pro Glu Ala Thr Gly Met 
385                 390                 395                 400 


Thr Pro Ala Glu Val Ser Ile Val Val Leu Ser Gly Thr Thr Ala Ala 
                405                 410                 415     


Gln Val Thr Thr Thr Glu Trp Val Glu Thr Thr Ala Arg Glu Leu Pro 
            420                 425                 430         


Ile Pro Glu Pro Glu Gly Pro Asp Ala Ser Ser Ile Met Ser Thr Glu 
        435                 440                 445             


Ser Ile Thr Gly Ser Leu Gly Pro Leu Leu Asp Gly Thr Ala Thr Leu 
    450                 455                 460                 


Arg Leu Val Lys Arg Gln Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr 
465                 470                 475                 480 


Gly Ser Phe Ser Val Thr Leu Asp Ile Val Gln Gly Ile Glu Ser Ala 
                485                 490                 495     


Glu Ile Leu Gln Ala Val Pro Ser Gly Glu Gly Asp Ala Phe Glu Leu 
            500                 505                 510         


Thr Val Ser Cys Gln Gly Gly Leu Pro Lys Glu Ala Cys Met Glu Ile 
        515                 520                 525             


Ser Ser Pro Gly Cys Gln Pro Pro Ala Gln Arg Leu Cys Gln Pro Val 
    530                 535                 540                 


Leu Pro Ser Pro Ala Cys Gln Leu Val Leu His Gln Ile Leu Lys Gly 
545                 550                 555                 560 


Gly Ser Gly Thr Tyr Cys Leu Asn Val Ser Leu Ala Asp Thr Asn Ser 
                565                 570                 575     


Leu Ala Val Val Ser Thr Gln Leu Ile Met Pro Gly Gln Glu Ala Gly 
            580                 585                 590         


Leu Gly Gln Val Pro Leu Ile Val Gly Ile Leu Leu Val Leu Met Ala 
        595                 600                 605             


Val Val Leu Ala Ser Leu Ile Tyr Arg Arg Arg Leu Met Lys Gln Asp 
    610                 615                 620                 


Phe Ser Val Pro Gln Leu Pro His Ser Ser Ser His Trp Leu Arg Leu 
625                 630                 635                 640 


Pro Arg Ile Phe Cys Ser Cys Pro Ile Gly Glu Asn Ser Pro Leu Leu 
                645                 650                 655     


Ser Gly Gln Gln Val 
            660     


<210>  3598
<211>  496
<212>  PRT
<213>  Homo sapiens

<400>  3598

Met Gly Thr Gln Lys Val Thr Pro Ala Leu Ile Phe Ala Ile Thr Val 
1               5                   10                  15      


Ala Thr Ile Gly Ser Phe Gln Phe Gly Tyr Asn Thr Gly Val Ile Asn 
            20                  25                  30          


Ala Pro Glu Lys Ile Ile Lys Glu Phe Ile Asn Lys Thr Leu Thr Asp 
        35                  40                  45              


Lys Gly Asn Ala Pro Pro Ser Glu Val Leu Leu Thr Ser Leu Trp Ser 
    50                  55                  60                  


Leu Ser Val Ala Ile Phe Ser Val Gly Gly Met Ile Gly Ser Phe Ser 
65                  70                  75                  80  


Val Gly Leu Phe Val Asn Arg Phe Gly Arg Arg Asn Ser Met Leu Ile 
                85                  90                  95      


Val Asn Leu Leu Ala Val Thr Gly Gly Cys Phe Met Gly Leu Cys Lys 
            100                 105                 110         


Val Ala Lys Ser Val Glu Met Leu Ile Leu Gly Arg Leu Val Ile Gly 
        115                 120                 125             


Leu Phe Cys Gly Leu Cys Thr Gly Phe Val Pro Met Tyr Ile Gly Glu 
    130                 135                 140                 


Ile Ser Pro Thr Ala Leu Arg Gly Ala Phe Gly Thr Leu Asn Gln Leu 
145                 150                 155                 160 


Gly Ile Val Val Gly Ile Leu Val Ala Gln Ile Phe Gly Leu Glu Phe 
                165                 170                 175     


Ile Leu Gly Ser Glu Glu Leu Trp Pro Leu Leu Leu Gly Phe Thr Ile 
            180                 185                 190         


Leu Pro Ala Ile Leu Gln Ser Ala Ala Leu Pro Phe Cys Pro Glu Ser 
        195                 200                 205             


Pro Arg Phe Leu Leu Ile Asn Arg Lys Glu Glu Glu Asn Ala Lys Gln 
    210                 215                 220                 


Ile Leu Gln Arg Leu Trp Gly Thr Gln Asp Val Ser Gln Asp Ile Gln 
225                 230                 235                 240 


Glu Met Lys Asp Glu Ser Ala Arg Met Ser Gln Glu Lys Gln Val Thr 
                245                 250                 255     


Val Leu Glu Leu Phe Arg Val Ser Ser Tyr Arg Gln Pro Ile Ile Ile 
            260                 265                 270         


Ser Ile Val Leu Gln Leu Ser Gln Gln Leu Ser Gly Ile Asn Ala Val 
        275                 280                 285             


Phe Tyr Tyr Ser Thr Gly Ile Phe Lys Asp Ala Gly Val Gln Glu Pro 
    290                 295                 300                 


Ile Tyr Ala Thr Ile Gly Ala Gly Val Val Asn Thr Ile Phe Thr Val 
305                 310                 315                 320 


Val Ser Leu Phe Leu Val Glu Arg Ala Gly Arg Arg Thr Leu His Met 
                325                 330                 335     


Ile Gly Leu Gly Gly Met Ala Phe Cys Ser Thr Leu Met Thr Val Ser 
            340                 345                 350         


Leu Leu Leu Lys Asp Asn Tyr Asn Gly Met Ser Phe Val Cys Ile Gly 
        355                 360                 365             


Ala Ile Leu Val Phe Val Ala Phe Phe Glu Ile Gly Pro Gly Pro Ile 
    370                 375                 380                 


Pro Trp Phe Ile Val Ala Glu Leu Phe Ser Gln Gly Pro Arg Pro Ala 
385                 390                 395                 400 


Ala Met Ala Val Ala Gly Cys Ser Asn Trp Thr Ser Asn Phe Leu Val 
                405                 410                 415     


Gly Leu Leu Phe Pro Ser Ala Ala His Tyr Leu Gly Ala Tyr Val Phe 
            420                 425                 430         


Ile Ile Phe Thr Gly Phe Leu Ile Thr Phe Leu Ala Phe Thr Phe Phe 
        435                 440                 445             


Lys Val Pro Glu Thr Arg Gly Arg Thr Phe Glu Asp Ile Thr Arg Ala 
    450                 455                 460                 


Phe Glu Gly Gln Ala His Gly Ala Asp Arg Ser Gly Lys Asp Gly Val 
465                 470                 475                 480 


Met Glu Met Asn Ser Ile Glu Pro Ala Lys Glu Thr Thr Thr Asn Val 
                485                 490                 495     


<210>  3599
<211>  718
<212>  PRT
<213>  Homo sapiens

<400>  3599

Met Arg Ala Val Leu Asp Thr Ala Asp Ile Ala Ile Val Ala Leu Tyr 
1               5                   10                  15      


Phe Ile Leu Val Met Cys Ile Gly Phe Phe Ala Met Trp Lys Ser Asn 
            20                  25                  30          


Arg Ser Thr Val Ser Gly Tyr Phe Leu Ala Gly Arg Ser Met Thr Trp 
        35                  40                  45              


Val Ala Ile Gly Ala Ser Leu Phe Val Ser Asn Ile Gly Ser Glu His 
    50                  55                  60                  


Phe Ile Gly Leu Ala Gly Ser Gly Ala Ala Ser Gly Phe Ala Val Gly 
65                  70                  75                  80  


Ala Trp Glu Phe Asn Ala Leu Leu Leu Leu Gln Leu Leu Gly Trp Val 
                85                  90                  95      


Phe Ile Pro Ile Tyr Ile Arg Ser Gly Val Tyr Thr Met Pro Glu Tyr 
            100                 105                 110         


Leu Ser Lys Arg Phe Gly Gly His Arg Ile Gln Val Tyr Phe Ala Ala 
        115                 120                 125             


Leu Ser Leu Ile Leu Tyr Ile Phe Thr Lys Leu Ser Val Asp Leu Tyr 
    130                 135                 140                 


Ser Gly Ala Leu Phe Ile Gln Glu Ser Leu Gly Trp Asn Leu Tyr Val 
145                 150                 155                 160 


Ser Val Ile Leu Leu Ile Gly Met Thr Ala Leu Leu Thr Val Thr Gly 
                165                 170                 175     


Gly Leu Val Ala Val Ile Tyr Thr Asp Thr Leu Gln Ala Leu Leu Met 
            180                 185                 190         


Ile Ile Gly Ala Leu Thr Leu Met Ile Ile Ser Ile Met Glu Ile Gly 
        195                 200                 205             


Gly Phe Glu Glu Val Lys Arg Arg Tyr Met Leu Ala Ser Pro Asp Val 
    210                 215                 220                 


Thr Ser Ile Leu Leu Thr Tyr Asn Leu Ser Asn Thr Asn Ser Cys Asn 
225                 230                 235                 240 


Val Ser Pro Lys Lys Glu Ala Leu Lys Met Leu Arg Asn Pro Thr Asp 
                245                 250                 255     


Glu Asp Val Pro Trp Pro Gly Phe Ile Leu Gly Gln Thr Pro Ala Ser 
            260                 265                 270         


Val Trp Tyr Trp Cys Ala Asp Gln Val Ile Val Gln Arg Val Leu Ala 
        275                 280                 285             


Ala Lys Asn Ile Ala His Ala Lys Gly Ser Thr Leu Met Ala Gly Phe 
    290                 295                 300                 


Leu Lys Leu Leu Pro Met Phe Ile Ile Val Val Pro Gly Met Ile Ser 
305                 310                 315                 320 


Arg Ile Leu Phe Thr Asp Asp Ile Ala Cys Ile Asn Pro Glu His Cys 
                325                 330                 335     


Met Leu Val Cys Gly Ser Arg Ala Gly Cys Ser Asn Ile Ala Tyr Pro 
            340                 345                 350         


Arg Leu Val Met Lys Leu Val Pro Val Gly Leu Arg Gly Leu Met Met 
        355                 360                 365             


Ala Val Met Ile Ala Ala Leu Met Ser Asp Leu Asp Ser Ile Phe Asn 
    370                 375                 380                 


Ser Ala Ser Thr Ile Phe Thr Leu Asp Val Tyr Lys Leu Ile Arg Lys 
385                 390                 395                 400 


Ser Ala Ser Ser Arg Glu Leu Met Ile Val Gly Arg Ile Phe Val Ala 
                405                 410                 415     


Phe Met Val Val Ile Ser Ile Ala Trp Val Pro Ile Ile Val Glu Met 
            420                 425                 430         


Gln Gly Gly Gln Met Tyr Leu Tyr Ile Gln Glu Val Ala Asp Tyr Leu 
        435                 440                 445             


Thr Pro Pro Val Ala Ala Leu Phe Leu Leu Ala Ile Phe Trp Lys Arg 
    450                 455                 460                 


Cys Asn Glu Gln Gly Ala Phe Tyr Gly Gly Met Ala Gly Phe Val Leu 
465                 470                 475                 480 


Gly Ala Val Arg Leu Ile Leu Ala Phe Ala Tyr Arg Ala Pro Glu Cys 
                485                 490                 495     


Asp Gln Pro Asp Asn Arg Pro Gly Phe Ile Lys Asp Ile His Tyr Met 
            500                 505                 510         


Tyr Val Ala Thr Gly Leu Phe Trp Val Thr Gly Leu Ile Thr Val Ile 
        515                 520                 525             


Val Ser Leu Leu Thr Pro Pro Pro Thr Lys Glu Gln Ile Arg Thr Thr 
    530                 535                 540                 


Thr Phe Trp Ser Lys Lys Asn Leu Val Val Lys Glu Asn Cys Ser Pro 
545                 550                 555                 560 


Lys Glu Glu Pro Tyr Lys Met Gln Glu Lys Ser Ile Leu Arg Cys Ser 
                565                 570                 575     


Glu Asn Asn Glu Thr Ile Asn His Ile Ile Pro Asn Gly Lys Ser Glu 
            580                 585                 590         


Asp Ser Ile Lys Gly Leu Gln Pro Glu Asp Val Asn Leu Leu Val Thr 
        595                 600                 605             


Cys Arg Glu Glu Gly Asn Pro Val Ala Ser Leu Gly His Ser Glu Ala 
    610                 615                 620                 


Glu Thr Pro Val Asp Ala Tyr Ser Asn Gly Gln Ala Ala Leu Met Gly 
625                 630                 635                 640 


Glu Lys Glu Arg Lys Lys Glu Thr Asp Asp Gly Gly Arg Tyr Trp Lys 
                645                 650                 655     


Phe Ile Asp Trp Phe Cys Gly Phe Lys Ser Lys Ser Leu Ser Lys Arg 
            660                 665                 670         


Ser Leu Arg Asp Leu Met Glu Glu Glu Ala Val Cys Leu Gln Met Leu 
        675                 680                 685             


Glu Glu Thr Arg Gln Val Lys Val Ile Leu Asn Ile Gly Leu Phe Ala 
    690                 695                 700                 


Val Cys Ser Leu Gly Ile Phe Met Phe Val Tyr Phe Ser Leu 
705                 710                 715             


<210>  3600
<211>  652
<212>  PRT
<213>  Homo sapiens

<400>  3600

Met Ser Gly Gly Asp Thr Arg Ala Ala Ile Ala Arg Pro Arg Met Ala 
1               5                   10                  15      


Ala Ala His Gly Pro Val Ala Pro Ser Ser Pro Glu Gln Asn Gly Ala 
            20                  25                  30          


Val Pro Ser Glu Ala Thr Lys Arg Asp Gln Asn Leu Lys Arg Gly Asn 
        35                  40                  45              


Trp Gly Asn Gln Ile Glu Phe Val Leu Thr Ser Val Gly Tyr Ala Val 
    50                  55                  60                  


Gly Leu Gly Asn Val Trp Arg Phe Pro Tyr Leu Cys Tyr Arg Asn Gly 
65                  70                  75                  80  


Gly Gly Ala Phe Met Phe Pro Tyr Phe Ile Met Leu Ile Phe Cys Gly 
                85                  90                  95      


Ile Pro Leu Phe Phe Met Glu Leu Ser Phe Gly Gln Phe Ala Ser Gln 
            100                 105                 110         


Gly Cys Leu Gly Val Trp Arg Ile Ser Pro Met Phe Lys Gly Val Gly 
        115                 120                 125             


Tyr Gly Met Met Val Val Ser Thr Tyr Ile Gly Ile Tyr Tyr Asn Val 
    130                 135                 140                 


Val Ile Cys Ile Ala Phe Tyr Tyr Phe Phe Ser Ser Met Thr His Val 
145                 150                 155                 160 


Leu Pro Trp Ala Tyr Cys Asn Asn Pro Trp Asn Thr His Asp Cys Ala 
                165                 170                 175     


Gly Val Leu Asp Ala Ser Asn Leu Thr Asn Gly Ser Arg Pro Ala Ala 
            180                 185                 190         


Leu Pro Ser Asn Leu Ser His Leu Leu Asn His Ser Leu Gln Arg Thr 
        195                 200                 205             


Ser Pro Ser Glu Glu Tyr Trp Arg Leu Tyr Val Leu Lys Leu Ser Asp 
    210                 215                 220                 


Asp Ile Gly Asn Phe Gly Glu Val Arg Leu Pro Leu Leu Gly Cys Leu 
225                 230                 235                 240 


Gly Val Ser Trp Leu Val Val Phe Leu Cys Leu Ile Arg Gly Val Lys 
                245                 250                 255     


Ser Ser Gly Lys Val Val Tyr Phe Thr Ala Thr Phe Pro Tyr Val Val 
            260                 265                 270         


Leu Thr Ile Leu Phe Val Arg Gly Val Thr Leu Glu Gly Ala Phe Asp 
        275                 280                 285             


Gly Ile Met Tyr Tyr Leu Thr Pro Gln Trp Asp Lys Ile Leu Glu Ala 
    290                 295                 300                 


Lys Val Trp Gly Asp Ala Ala Ser Gln Ile Phe Tyr Ser Leu Gly Cys 
305                 310                 315                 320 


Ala Trp Gly Gly Leu Ile Thr Met Ala Ser Tyr Asn Lys Phe His Asn 
                325                 330                 335     


Asn Cys Tyr Arg Asp Ser Val Ile Ile Ser Ile Thr Asn Cys Ala Thr 
            340                 345                 350         


Ser Val Tyr Ala Gly Phe Val Ile Phe Ser Ile Leu Gly Phe Met Ala 
        355                 360                 365             


Asn His Leu Gly Val Asp Val Ser Arg Val Ala Asp His Gly Pro Gly 
    370                 375                 380                 


Leu Ala Phe Val Ala Tyr Pro Glu Ala Leu Thr Leu Leu Pro Ile Ser 
385                 390                 395                 400 


Pro Leu Trp Ser Leu Leu Phe Phe Phe Met Leu Ile Leu Leu Gly Leu 
                405                 410                 415     


Gly Thr Gln Phe Cys Leu Leu Glu Thr Leu Val Thr Ala Ile Val Asp 
            420                 425                 430         


Glu Val Gly Asn Glu Trp Ile Leu Gln Lys Lys Thr Tyr Val Thr Leu 
        435                 440                 445             


Gly Val Ala Val Ala Gly Phe Leu Leu Gly Ile Pro Leu Thr Ser Gln 
    450                 455                 460                 


Ala Gly Ile Tyr Trp Leu Leu Leu Met Asp Asn Tyr Ala Ala Ser Phe 
465                 470                 475                 480 


Ser Leu Val Val Ile Ser Cys Ile Met Cys Val Ala Ile Met Tyr Ile 
                485                 490                 495     


Tyr Gly His Arg Asn Tyr Phe Gln Asp Ile Gln Met Met Leu Gly Phe 
            500                 505                 510         


Pro Pro Pro Leu Phe Phe Gln Ile Cys Trp Arg Phe Val Ser Pro Ala 
        515                 520                 525             


Ile Ile Phe Phe Ile Leu Val Phe Thr Val Ile Gln Tyr Gln Pro Ile 
    530                 535                 540                 


Thr Tyr Asn His Tyr Gln Tyr Pro Gly Trp Ala Val Ala Ile Gly Phe 
545                 550                 555                 560 


Leu Met Ala Leu Ser Ser Val Leu Cys Ile Pro Leu Tyr Ala Met Phe 
                565                 570                 575     


Arg Leu Cys Arg Thr Asp Gly Asp Thr Leu Leu Gln Arg Leu Lys Asn 
            580                 585                 590         


Ala Thr Lys Pro Ser Arg Asp Trp Gly Pro Ala Leu Leu Glu His Arg 
        595                 600                 605             


Thr Gly Arg Tyr Ala Pro Thr Ile Ala Pro Ser Pro Glu Asp Gly Phe 
    610                 615                 620                 


Glu Val Gln Pro Leu His Pro Asp Lys Ala Gln Ile Pro Ile Val Gly 
625                 630                 635                 640 


Ser Asn Gly Ser Ser Arg Leu Gln Asp Ser Arg Ile 
                645                 650         


<210>  3601
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  3601

Met Ala Arg Glu Met Thr Ile Leu Gly Ser Ala Val Leu Thr Leu Leu 
1               5                   10                  15      


Leu Ala Gly Tyr Leu Ala Gln Gln Tyr Leu Pro Leu Pro Thr Pro Lys 
            20                  25                  30          


Val Ile Gly Ile Asp Leu Gly Thr Thr Tyr Cys Ser Val Gly Val Phe 
        35                  40                  45              


Phe Pro Gly Thr Gly Lys Val Lys Val Ile Pro Asp Glu Asn Gly His 
    50                  55                  60                  


Ile Ser Ile Pro Ser Met Val Ser Phe Thr Asp Asn Asp Val Tyr Val 
65                  70                  75                  80  


Gly Tyr Glu Ser Val Glu Leu Ala Asp Ser Asn Pro Gln Asn Thr Ile 
                85                  90                  95      


Tyr Asp Ala Lys Arg Phe Ile Gly Lys Ile Phe Thr Ala Glu Glu Leu 
            100                 105                 110         


Glu Ala Glu Ile Gly Arg Tyr Pro Phe Lys Val Leu Asn Lys Asn Gly 
        115                 120                 125             


Met Val Glu Phe Ser Val Thr Ser Asn Glu Thr Ile Thr Val Ser Pro 
    130                 135                 140                 


Glu Tyr Val Gly Ser Arg Leu Leu Leu Lys Leu Lys Glu Met Ala Glu 
145                 150                 155                 160 


Ala Tyr Leu Gly Met Pro Val Ala Asn Ala Val Ile Ser Val Pro Ala 
                165                 170                 175     


Glu Phe Asp Leu Lys Gln Arg Asn Ser Thr Ile Glu Ala Ala Asn Leu 
            180                 185                 190         


Ala Gly Leu Lys Ile Leu Arg Val Ile Asn Glu Pro Thr Ala Ala Ala 
        195                 200                 205             


Met Ala Tyr Gly Leu His Lys Ala Asp Val Phe His Val Leu Val Ile 
    210                 215                 220                 


Asp Leu Gly Gly Gly Thr Leu Asp Val Ser Leu Leu Asn Lys Gln Gly 
225                 230                 235                 240 


Gly Met Phe Leu Thr Arg Ala Met Ser Gly Asn Asn Lys Leu Gly Gly 
                245                 250                 255     


Gln Asp Phe Asn Gln Arg Leu Leu Gln Tyr Leu Tyr Lys Gln Ile Tyr 
            260                 265                 270         


Gln Thr Tyr Gly Phe Val Pro Ser Arg Lys Glu Glu Ile His Arg Leu 
        275                 280                 285             


Arg Gln Ala Val Glu Met Val Lys Leu Asn Leu Thr Leu His Gln Ser 
    290                 295                 300                 


Ala Gln Leu Ser Val Leu Leu Thr Val Glu Glu Gln Asp Arg Lys Glu 
305                 310                 315                 320 


Pro His Ser Ser Asp Thr Glu Leu Pro Lys Asp Lys Leu Ser Ser Ala 
                325                 330                 335     


Asp Asp His Arg Val Asn Ser Gly Phe Gly Arg Gly Leu Ser Asp Lys 
            340                 345                 350         


Lys Ser Gly Glu Ser Gln Val Leu Phe Glu Thr Glu Ile Ser Arg Lys 
        355                 360                 365             


Leu Phe Asp Thr Leu Asn Glu Asp Leu Phe Gln Lys Ile Leu Val Pro 
    370                 375                 380                 


Ile Gln Gln Val Leu Lys Glu Gly His Leu Glu Lys Thr Glu Ile Asp 
385                 390                 395                 400 


Glu Val Val Leu Val Gly Gly Ser Thr Arg Ile Pro Arg Ile Arg Gln 
                405                 410                 415     


Val Ile Gln Glu Phe Phe Gly Lys Asp Pro Asn Thr Ser Val Asp Pro 
            420                 425                 430         


Asp Leu Ala Val Val Thr Gly Val Ala Ile Gln Ala Gly Ile Asp Gly 
        435                 440                 445             


Gly Ser Trp Pro Leu Gln Val Ser Ala Leu Glu Ile Pro Asn Lys His 
    450                 455                 460                 


Leu Gln Lys Thr Asn Phe Asn 
465                 470     


<210>  3602
<211>  593
<212>  PRT
<213>  Homo sapiens

<400>  3602

Met Ala Pro Ser Gly Leu Lys Ala Val Val Gly Glu Lys Ile Leu Ser 
1               5                   10                  15      


Gly Val Ile Arg Ser Val Lys Lys Asp Gly Glu Trp Lys Val Leu Ile 
            20                  25                  30          


Met Asp His Pro Ser Met Arg Ile Leu Ser Ser Cys Cys Lys Met Ser 
        35                  40                  45              


Asp Ile Leu Ala Glu Gly Ile Thr Ile Val Glu Asp Ile Asn Lys Arg 
    50                  55                  60                  


Arg Glu Pro Ile Pro Ser Leu Glu Ala Ile Tyr Leu Leu Ser Pro Thr 
65                  70                  75                  80  


Glu Lys Ser Val Gln Ala Leu Ile Lys Asp Phe Gln Gly Thr Pro Thr 
                85                  90                  95      


Phe Thr Tyr Lys Ala Ala His Ile Phe Phe Thr Asp Thr Cys Pro Glu 
            100                 105                 110         


Pro Leu Phe Ser Glu Leu Gly Arg Ser Arg Leu Ala Lys Val Val Lys 
        115                 120                 125             


Thr Leu Lys Glu Ile His Leu Ala Phe Leu Pro Tyr Glu Ala Gln Val 
    130                 135                 140                 


Phe Ser Leu Asp Ala Pro His Ser Thr Tyr Asn Leu Tyr Cys Pro Phe 
145                 150                 155                 160 


Arg Ala Glu Glu Arg Thr Arg Gln Leu Glu Val Leu Ala Gln Gln Ile 
                165                 170                 175     


Ala Thr Leu Cys Ala Thr Leu Gln Glu Tyr Pro Ala Ile Arg Tyr Arg 
            180                 185                 190         


Lys Gly Pro Glu Asp Thr Ala Gln Leu Ala His Ala Val Leu Ala Lys 
        195                 200                 205             


Leu Asn Ala Phe Lys Ala Asp Thr Pro Ser Leu Gly Glu Gly Pro Glu 
    210                 215                 220                 


Lys Thr Arg Ser Gln Leu Leu Ile Met Asp Arg Ala Ala Asp Pro Val 
225                 230                 235                 240 


Ser Pro Leu Leu His Glu Leu Thr Phe Gln Ala Met Ala Tyr Asp Leu 
                245                 250                 255     


Leu Asp Ile Glu Gln Asp Thr Tyr Arg Tyr Glu Thr Thr Gly Leu Ser 
            260                 265                 270         


Glu Ala Arg Glu Lys Ala Val Leu Leu Asp Glu Asp Asp Asp Leu Trp 
        275                 280                 285             


Val Glu Leu Arg His Met His Ile Ala Asp Val Ser Lys Lys Val Thr 
    290                 295                 300                 


Glu Leu Leu Arg Thr Phe Cys Glu Ser Lys Arg Leu Thr Thr Asp Lys 
305                 310                 315                 320 


Ala Asn Ile Lys Asp Leu Ser Gln Ile Leu Lys Lys Met Pro Gln Tyr 
                325                 330                 335     


Gln Lys Glu Leu Asn Lys Tyr Ser Thr His Leu His Leu Ala Asp Asp 
            340                 345                 350         


Cys Met Lys His Phe Lys Gly Ser Val Glu Lys Leu Cys Ser Val Glu 
        355                 360                 365             


Gln Asp Leu Ala Met Gly Ser Asp Ala Glu Gly Glu Lys Ile Lys Asp 
    370                 375                 380                 


Ser Met Lys Leu Ile Val Pro Val Leu Leu Asp Ala Ala Val Pro Ala 
385                 390                 395                 400 


Tyr Asp Lys Ile Arg Val Leu Leu Leu Tyr Ile Leu Leu Arg Asn Gly 
                405                 410                 415     


Val Ser Glu Glu Asn Leu Ala Lys Leu Ile Gln His Ala Asn Val Gln 
            420                 425                 430         


Ala His Ser Ser Leu Ile Arg Asn Leu Glu Gln Leu Gly Gly Thr Val 
        435                 440                 445             


Thr Asn Pro Gly Gly Ser Gly Thr Ser Ser Arg Leu Glu Pro Arg Glu 
    450                 455                 460                 


Arg Met Glu Pro Thr Tyr Gln Leu Ser Arg Trp Thr Pro Val Ile Lys 
465                 470                 475                 480 


Asp Val Met Glu Asp Ala Val Glu Asp Arg Leu Asp Arg Asn Leu Trp 
                485                 490                 495     


Pro Phe Val Ser Asp Pro Ala Pro Thr Ala Ser Ser Gln Ala Ala Val 
            500                 505                 510         


Ser Ala Arg Phe Gly His Trp His Lys Asn Lys Ala Gly Ile Glu Ala 
        515                 520                 525             


Arg Ala Gly Pro Arg Leu Ile Val Tyr Val Met Gly Gly Val Ala Met 
    530                 535                 540                 


Ser Glu Met Arg Ala Ala Tyr Glu Val Thr Arg Ala Thr Glu Gly Lys 
545                 550                 555                 560 


Trp Glu Val Leu Ile Gly Ser Ser His Ile Leu Thr Pro Thr Arg Phe 
                565                 570                 575     


Leu Asp Asp Leu Lys Ala Leu Asp Lys Lys Leu Glu Asp Ile Ala Leu 
            580                 585                 590         


Pro 
    


<210>  3603
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  3603

Met Ala Lys Asp Asn Ser Thr Val Arg Cys Phe Gln Gly Leu Leu Ile 
1               5                   10                  15      


Phe Gly Asn Val Ile Ile Gly Cys Cys Gly Ile Ala Leu Thr Ala Glu 
            20                  25                  30          


Cys Ile Phe Phe Val Ser Asp Gln His Ser Leu Tyr Pro Leu Leu Glu 
        35                  40                  45              


Ala Thr Asp Asn Asp Asp Ile Tyr Gly Ala Ala Trp Ile Gly Ile Phe 
    50                  55                  60                  


Val Gly Ile Cys Leu Phe Cys Leu Ser Val Leu Gly Ile Val Gly Ile 
65                  70                  75                  80  


Met Lys Ser Ser Arg Lys Ile Leu Leu Ala Tyr Phe Ile Leu Met Phe 
                85                  90                  95      


Ile Val Tyr Ala Phe Glu Val Ala Ser Cys Ile Thr Ala Ala Thr Gln 
            100                 105                 110         


Gln Asp Phe Phe Thr Pro Asn Leu Phe Leu Lys Gln Met Leu Glu Arg 
        115                 120                 125             


Tyr Gln Asn Asn Ser Pro Pro Asn Asn Asp Asp Gln Trp Lys Asn Asn 
    130                 135                 140                 


Gly Val Thr Lys Thr Trp Asp Arg Leu Met Leu Gln Asp Asn Cys Cys 
145                 150                 155                 160 


Gly Val Asn Gly Pro Ser Asp Trp Gln Lys Tyr Thr Ser Ala Phe Arg 
                165                 170                 175     


Thr Glu Asn Asn Asp Ala Asp Tyr Pro Trp Pro Arg Gln Cys Cys Val 
            180                 185                 190         


Met Asn Asn Leu Lys Glu Pro Leu Asn Leu Glu Ala Cys Lys Leu Gly 
        195                 200                 205             


Val Pro Gly Phe Tyr His Asn Gln Gly Cys Tyr Glu Leu Ile Ser Gly 
    210                 215                 220                 


Pro Met Asn Arg His Ala Trp Gly Val Ala Trp Phe Gly Phe Ala Ile 
225                 230                 235                 240 


Leu Cys Trp Thr Phe Trp Val Leu Leu Gly Thr Met Phe Tyr Trp Ser 
                245                 250                 255     


Arg Ile Glu Tyr 
            260 


<210>  3604
<211>  287
<212>  PRT
<213>  Homo sapiens

<400>  3604

Met Pro Pro Leu Trp Ala Leu Leu Ala Leu Gly Cys Leu Arg Phe Gly 
1               5                   10                  15      


Ser Ala Val Asn Leu Gln Pro Gln Leu Ala Ser Val Thr Phe Ala Thr 
            20                  25                  30          


Asn Asn Pro Thr Leu Thr Thr Val Ala Leu Glu Lys Pro Leu Cys Met 
        35                  40                  45              


Phe Asp Ser Lys Glu Ala Leu Thr Gly Thr His Glu Val Tyr Leu Tyr 
    50                  55                  60                  


Val Leu Val Asp Ser Ala Ile Ser Arg Asn Ala Ser Val Gln Asp Ser 
65                  70                  75                  80  


Thr Asn Thr Pro Leu Gly Ser Thr Phe Leu Gln Thr Glu Gly Gly Arg 
                85                  90                  95      


Thr Gly Pro Tyr Lys Ala Val Ala Phe Asp Leu Ile Pro Cys Ser Asp 
            100                 105                 110         


Leu Pro Ser Leu Asp Ala Ile Gly Asp Val Ser Lys Ala Ser Gln Ile 
        115                 120                 125             


Leu Asn Ala Tyr Leu Val Arg Val Gly Ala Asn Gly Thr Cys Leu Trp 
    130                 135                 140                 


Asp Pro Asn Phe Gln Gly Leu Cys Asn Ala Pro Leu Ser Ala Ala Thr 
145                 150                 155                 160 


Glu Tyr Arg Phe Lys Tyr Val Leu Val Asn Met Ser Thr Gly Leu Val 
                165                 170                 175     


Glu Asp Gln Thr Leu Trp Ser Asp Pro Ile Arg Thr Asn Gln Leu Thr 
            180                 185                 190         


Pro Tyr Ser Thr Ile Asp Thr Trp Pro Gly Arg Arg Ser Gly Gly Met 
        195                 200                 205             


Ile Val Ile Thr Ser Ile Leu Gly Ser Leu Pro Phe Phe Leu Leu Val 
    210                 215                 220                 


Gly Phe Ala Gly Ala Ile Ala Leu Ser Leu Val Asp Met Gly Ser Ser 
225                 230                 235                 240 


Asp Gly Glu Thr Thr His Asp Ser Gln Ile Thr Gln Glu Ala Val Pro 
                245                 250                 255     


Lys Ser Leu Gly Ala Ser Glu Ser Ser Tyr Thr Ser Val Asn Arg Gly 
            260                 265                 270         


Pro Pro Leu Asp Arg Ala Glu Val Tyr Ser Ser Lys Leu Gln Asp 
        275                 280                 285         


<210>  3605
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  3605

Met Ala Arg Gly Leu Gly Ala Pro His Trp Val Ala Val Gly Leu Leu 
1               5                   10                  15      


Thr Trp Ala Thr Leu Gly Leu Leu Val Ala Gly Leu Gly Gly His Asp 
            20                  25                  30          


Asp Leu His Asp Asp Leu Gln Glu Asp Phe His Gly His Ser His Arg 
        35                  40                  45              


His Ser His Glu Asp Phe His His Gly His Ser His Ala His Gly His 
    50                  55                  60                  


Gly His Thr His Glu Ser Ile Trp His Gly His Thr His Asp His Asp 
65                  70                  75                  80  


His Gly His Ser His Glu Asp Leu His His Gly His Ser His Gly Tyr 
                85                  90                  95      


Ser His Glu Ser Leu Tyr His Arg Gly His Gly His Asp His Glu His 
            100                 105                 110         


Ser His Gly Gly Tyr Gly Glu Ser Gly Ala Pro Gly Ile Lys Gln Asp 
        115                 120                 125             


Leu Asp Ala Val Thr Leu Trp Ala Tyr Ala Leu Gly Ala Thr Val Leu 
    130                 135                 140                 


Ile Ser Ala Ala Pro Phe Phe Val Leu Phe Leu Ile Pro Val Glu Ser 
145                 150                 155                 160 


Asn Ser Pro Arg His Arg Ser Leu Leu Gln Ile Leu Leu Ser Phe Ala 
                165                 170                 175     


Ser Gly Gly Leu Leu Gly Asp Ala Phe Leu His Leu Ile Pro His Ala 
            180                 185                 190         


Leu Glu Pro His Ser His His Thr Leu Glu Gln Pro Gly His Gly His 
        195                 200                 205             


Ser His Ser Gly Gln Gly Pro Ile Leu Ser Val Gly Leu Trp Val Leu 
    210                 215                 220                 


Ser Gly Ile Val Ala Phe Leu Val Val Glu Lys Phe Val Arg His Val 
225                 230                 235                 240 


Lys Gly Gly His Gly His Ser His Gly His Gly His Ala His Ser His 
                245                 250                 255     


Thr Arg Gly Ser His Gly His Gly Arg Gln Glu Arg Ser Thr Lys Glu 
            260                 265                 270         


Lys Gln Ser Ser Glu Glu Glu Glu Lys Glu Thr Arg Gly Val Gln Lys 
        275                 280                 285             


Arg Arg Gly Gly Ser Thr Val Pro Lys Asp Gly Pro Val Arg Pro Gln 
    290                 295                 300                 


Asn Ala Glu Glu Glu Lys Arg Gly Leu Asp Leu Arg Val Ser Gly Tyr 
305                 310                 315                 320 


Leu Asn Leu Ala Ala Asp Leu Ala His Asn Phe Thr Asp Gly Leu Ala 
                325                 330                 335     


Ile Gly Ala Ser Phe Arg Gly Gly Arg Gly Leu Gly Ile Leu Thr Thr 
            340                 345                 350         


Met Thr Val Leu Leu His Glu Val Pro His Glu Val Gly Asp Phe Ala 
        355                 360                 365             


Ile Leu Val Gln Ser Gly Cys Ser Lys Lys Gln Ala Met Arg Leu Gln 
    370                 375                 380                 


Leu Leu Thr Ala Val Gly Ala Leu Ala Gly Thr Ala Cys Ala Leu Leu 
385                 390                 395                 400 


Thr Glu Gly Gly Ala Val Gly Ser Glu Ile Ala Gly Gly Ala Gly Pro 
                405                 410                 415     


Gly Trp Val Leu Pro Phe Thr Ala Gly Gly Phe Ile Tyr Val Ala Thr 
            420                 425                 430         


Val Ser Val Leu Pro Glu Leu Leu Arg Glu Ala Ser Pro Leu Gln Ser 
        435                 440                 445             


Leu Leu Glu Val Leu Gly Leu Leu Gly Gly Val Ile Met Met Val Leu 
    450                 455                 460                 


Ile Ala His Leu Glu 
465                 


<210>  3606
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  3606

Met Ala Ser Thr Ala Ser Glu Ile Ile Ala Phe Met Val Ser Ile Ser 
1               5                   10                  15      


Gly Trp Val Leu Val Ser Ser Thr Leu Pro Thr Asp Tyr Trp Lys Val 
            20                  25                  30          


Ser Thr Ile Asp Gly Thr Val Ile Thr Thr Ala Thr Tyr Trp Ala Asn 
        35                  40                  45              


Leu Trp Lys Ala Cys Val Thr Asp Ser Thr Gly Val Ser Asn Cys Lys 
    50                  55                  60                  


Asp Phe Pro Ser Met Leu Ala Leu Asp Gly Tyr Ile Gln Ala Cys Arg 
65                  70                  75                  80  


Gly Leu Met Ile Ala Ala Val Ser Leu Gly Phe Phe Gly Ser Ile Phe 
                85                  90                  95      


Ala Leu Phe Gly Met Lys Cys Thr Lys Val Gly Gly Ser Asp Lys Ala 
            100                 105                 110         


Lys Ala Lys Ile Ala Cys Leu Ala Gly Ile Val Phe Ile Leu Ser Gly 
        115                 120                 125             


Leu Cys Ser Met Thr Gly Cys Ser Leu Tyr Ala Asn Lys Ile Thr Thr 
    130                 135                 140                 


Glu Phe Phe Asp Pro Leu Phe Val Glu Gln Lys Tyr Glu Leu Gly Ala 
145                 150                 155                 160 


Ala Leu Phe Ile Gly Trp Ala Gly Ala Ser Leu Cys Ile Ile Gly Gly 
                165                 170                 175     


Val Ile Phe Cys Phe Ser Ile Ser Asp Asn Asn Lys Thr Pro Arg Tyr 
            180                 185                 190         


Thr Tyr Asn Gly Ala Thr Ser Val Met Ser Ser Arg Thr Lys Tyr His 
        195                 200                 205             


Gly Gly Glu Asp Phe Lys Thr Thr Asn Pro Ser Lys Gln Phe Asp Lys 
    210                 215                 220                 


Asn Ala Tyr Val 
225             


<210>  3607
<211>  967
<212>  PRT
<213>  Homo sapiens

<400>  3607

Met Gln Arg Ala Val Pro Glu Gly Phe Gly Arg Arg Lys Leu Gly Ser 
1               5                   10                  15      


Asp Met Gly Asn Ala Glu Arg Ala Pro Gly Ser Arg Ser Phe Gly Pro 
            20                  25                  30          


Val Pro Thr Leu Leu Leu Leu Ala Ala Ala Leu Leu Ala Val Ser Asp 
        35                  40                  45              


Ala Leu Gly Arg Pro Ser Glu Glu Asp Glu Glu Leu Val Val Pro Glu 
    50                  55                  60                  


Leu Glu Arg Ala Pro Gly His Gly Thr Thr Arg Leu Arg Leu His Ala 
65                  70                  75                  80  


Phe Asp Gln Gln Leu Asp Leu Glu Leu Arg Pro Asp Ser Ser Phe Leu 
                85                  90                  95      


Ala Pro Gly Phe Thr Leu Gln Asn Val Gly Arg Lys Ser Gly Ser Glu 
            100                 105                 110         


Thr Pro Leu Pro Glu Thr Asp Leu Ala His Cys Phe Tyr Ser Gly Thr 
        115                 120                 125             


Val Asn Gly Asp Pro Ser Ser Ala Ala Ala Leu Ser Leu Cys Glu Gly 
    130                 135                 140                 


Val Arg Gly Ala Phe Tyr Leu Leu Gly Glu Ala Tyr Phe Ile Gln Pro 
145                 150                 155                 160 


Leu Pro Ala Ala Ser Glu Arg Leu Ala Thr Ala Ala Pro Gly Glu Lys 
                165                 170                 175     


Pro Pro Ala Pro Leu Gln Phe His Leu Leu Arg Arg Asn Arg Gln Gly 
            180                 185                 190         


Asp Val Gly Gly Thr Cys Gly Val Val Asp Asp Glu Pro Arg Pro Thr 
        195                 200                 205             


Gly Lys Ala Glu Thr Glu Asp Glu Asp Glu Gly Thr Glu Gly Glu Asp 
    210                 215                 220                 


Glu Gly Ala Gln Trp Ser Pro Gln Asp Pro Ala Leu Gln Gly Val Gly 
225                 230                 235                 240 


Gln Pro Thr Gly Thr Gly Ser Ile Arg Lys Lys Arg Phe Val Ser Ser 
                245                 250                 255     


His Arg Tyr Val Glu Thr Met Leu Val Ala Asp Gln Ser Met Ala Glu 
            260                 265                 270         


Phe His Gly Ser Gly Leu Lys His Tyr Leu Leu Thr Leu Phe Ser Val 
        275                 280                 285             


Ala Ala Arg Leu Tyr Lys His Pro Ser Ile Arg Asn Ser Val Ser Leu 
    290                 295                 300                 


Val Val Val Lys Ile Leu Val Ile His Asp Glu Gln Lys Gly Pro Glu 
305                 310                 315                 320 


Val Thr Ser Asn Ala Ala Leu Thr Leu Arg Asn Phe Cys Asn Trp Gln 
                325                 330                 335     


Lys Gln His Asn Pro Pro Ser Asp Arg Asp Ala Glu His Tyr Asp Thr 
            340                 345                 350         


Ala Ile Leu Phe Thr Arg Gln Asp Leu Cys Gly Ser Gln Thr Cys Asp 
        355                 360                 365             


Thr Leu Gly Met Ala Asp Val Gly Thr Val Cys Asp Pro Ser Arg Ser 
    370                 375                 380                 


Cys Ser Val Ile Glu Asp Asp Gly Leu Gln Ala Ala Phe Thr Thr Ala 
385                 390                 395                 400 


His Glu Leu Gly His Val Phe Asn Met Pro His Asp Asp Ala Lys Gln 
                405                 410                 415     


Cys Ala Ser Leu Asn Gly Val Asn Gln Asp Ser His Met Met Ala Ser 
            420                 425                 430         


Met Leu Ser Asn Leu Asp His Ser Gln Pro Trp Ser Pro Cys Ser Ala 
        435                 440                 445             


Tyr Met Ile Thr Ser Phe Leu Asp Asn Gly His Gly Glu Cys Leu Met 
    450                 455                 460                 


Asp Lys Pro Gln Asn Pro Ile Gln Leu Pro Gly Asp Leu Pro Gly Thr 
465                 470                 475                 480 


Ser Tyr Asp Ala Asn Arg Gln Cys Gln Phe Thr Phe Gly Glu Asp Ser 
                485                 490                 495     


Lys His Cys Pro Asp Ala Ala Ser Thr Cys Ser Thr Leu Trp Cys Thr 
            500                 505                 510         


Gly Thr Ser Gly Gly Val Leu Val Cys Gln Thr Lys His Phe Pro Trp 
        515                 520                 525             


Ala Asp Gly Thr Ser Cys Gly Glu Gly Lys Trp Cys Ile Asn Gly Lys 
    530                 535                 540                 


Cys Val Asn Lys Thr Asp Arg Lys His Phe Asp Thr Pro Phe His Gly 
545                 550                 555                 560 


Ser Trp Gly Met Trp Gly Pro Trp Gly Asp Cys Ser Arg Thr Cys Gly 
                565                 570                 575     


Gly Gly Val Gln Tyr Thr Met Arg Glu Cys Asp Asn Pro Val Pro Lys 
            580                 585                 590         


Asn Gly Gly Lys Tyr Cys Glu Gly Lys Arg Val Arg Tyr Arg Ser Cys 
        595                 600                 605             


Asn Leu Glu Asp Cys Pro Asp Asn Asn Gly Lys Thr Phe Arg Glu Glu 
    610                 615                 620                 


Gln Cys Glu Ala His Asn Glu Phe Ser Lys Ala Ser Phe Gly Ser Gly 
625                 630                 635                 640 


Pro Ala Val Glu Trp Ile Pro Lys Tyr Ala Gly Val Ser Pro Lys Asp 
                645                 650                 655     


Arg Cys Lys Leu Ile Cys Gln Ala Lys Gly Ile Gly Tyr Phe Phe Val 
            660                 665                 670         


Leu Gln Pro Lys Val Val Asp Gly Thr Pro Cys Ser Pro Asp Ser Thr 
        675                 680                 685             


Ser Val Cys Val Gln Gly Gln Cys Val Lys Ala Gly Cys Asp Arg Ile 
    690                 695                 700                 


Ile Asp Ser Lys Lys Lys Phe Asp Lys Cys Gly Val Cys Gly Gly Asn 
705                 710                 715                 720 


Gly Ser Thr Cys Lys Lys Ile Ser Gly Ser Val Thr Ser Ala Lys Pro 
                725                 730                 735     


Gly Tyr His Asp Ile Ile Thr Ile Pro Thr Gly Ala Thr Asn Ile Glu 
            740                 745                 750         


Val Lys Gln Arg Asn Gln Arg Gly Ser Arg Asn Asn Gly Ser Phe Leu 
        755                 760                 765             


Ala Ile Lys Ala Ala Asp Gly Thr Tyr Ile Leu Asn Gly Asp Tyr Thr 
    770                 775                 780                 


Leu Ser Thr Leu Glu Gln Asp Ile Met Tyr Lys Gly Val Val Leu Arg 
785                 790                 795                 800 


Tyr Ser Gly Ser Ser Ala Ala Leu Glu Arg Ile Arg Ser Phe Ser Pro 
                805                 810                 815     


Leu Lys Glu Pro Leu Thr Ile Gln Val Leu Thr Val Gly Asn Ala Leu 
            820                 825                 830         


Arg Pro Lys Ile Lys Tyr Thr Tyr Phe Val Lys Lys Lys Lys Glu Ser 
        835                 840                 845             


Phe Asn Ala Ile Pro Thr Phe Ser Ala Trp Val Ile Glu Glu Trp Gly 
    850                 855                 860                 


Glu Cys Ser Lys Ser Cys Glu Leu Gly Trp Gln Arg Arg Leu Val Glu 
865                 870                 875                 880 


Cys Arg Asp Ile Asn Gly Gln Pro Ala Ser Glu Cys Ala Lys Glu Val 
                885                 890                 895     


Lys Pro Ala Ser Thr Arg Pro Cys Ala Asp His Pro Cys Pro Gln Trp 
            900                 905                 910         


Gln Leu Gly Glu Trp Ser Ser Cys Ser Lys Thr Cys Gly Lys Gly Tyr 
        915                 920                 925             


Lys Lys Arg Ser Leu Lys Cys Leu Ser His Asp Gly Gly Val Leu Ser 
    930                 935                 940                 


His Glu Ser Cys Asp Pro Leu Lys Lys Pro Lys His Phe Ile Asp Phe 
945                 950                 955                 960 


Cys Thr Met Ala Glu Cys Ser 
                965         


<210>  3608
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  3608

Met Lys Met Ala Ser Ser Leu Ala Phe Leu Leu Leu Asn Phe His Val 
1               5                   10                  15      


Ser Leu Phe Leu Val Gln Leu Leu Thr Pro Cys Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Arg Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Ala Leu Gly Ser Asp Leu His Ile Glu Val Lys Gly Tyr Glu Asp Gly 
145                 150                 155                 160 


Gly Ile His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln 
                165                 170                 175     


Ile Lys Trp Ser Asp Thr Lys Gly Glu Asn Ile Pro Ala Val Glu Ala 
            180                 185                 190         


Pro Val Val Ala Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val 
        195                 200                 205             


Ile Met Arg Gly Ser Ser Gly Gly Gly Val Ser Cys Ile Ile Arg Asn 
    210                 215                 220                 


Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro 
225                 230                 235                 240 


Phe Phe Arg Ser Ala Gln Pro Trp Ile Ala Ala Leu Ala Gly Thr Leu 
                245                 250                 255     


Pro Ile Ser Leu Leu Leu Leu Ala Gly Ala Ser Tyr Phe Leu Trp Arg 
            260                 265                 270         


Gln Gln Lys Glu Lys Ile Ala Leu Ser Arg Glu Thr Glu Arg Glu Arg 
        275                 280                 285             


Glu Met Lys Glu Met Gly Tyr Ala Ala Thr Glu Gln Glu Ile Ser Leu 
    290                 295                 300                 


Arg Glu Lys Leu Gln Glu Glu Leu Lys Trp Arg Lys Ile Gln Tyr Met 
305                 310                 315                 320 


Ala Arg Gly Glu Lys Ser Leu Ala Tyr His Glu Trp Lys Met Ala Leu 
                325                 330                 335     


Phe Lys Pro Ala Asp Val Ile Leu Asp Pro Asp Thr Ala Asn Ala Ile 
            340                 345                 350         


Leu Leu Val Ser Glu Asp Gln Arg Ser Val Gln Arg Ala Glu Glu Pro 
        355                 360                 365             


Arg Asp Leu Pro Asp Asn Pro Glu Arg Phe Glu Trp Arg Tyr Cys Val 
    370                 375                 380                 


Leu Gly Cys Glu Asn Phe Thr Ser Gly Arg His Tyr Trp Glu Val Glu 
385                 390                 395                 400 


Val Gly Asp Arg Lys Glu Trp His Ile Gly Val Cys Ser Lys Asn Val 
                405                 410                 415     


Glu Arg Lys Lys Gly Trp Val Lys Met Thr Pro Glu Asn Gly Tyr Trp 
            420                 425                 430         


Thr Met Gly Leu Thr Asp Gly Asn Lys Tyr Arg Ala Leu Thr Glu Pro 
        435                 440                 445             


Arg Thr Asn Leu Lys Leu Pro Glu Pro Pro Arg Lys Val Gly Ile Phe 
    450                 455                 460                 


Leu Asp Tyr Glu Thr Gly Glu Ile Ser Phe Tyr Asn Ala Thr Asp Gly 
465                 470                 475                 480 


Ser His Ile Tyr Thr Phe Pro His Ala Ser Phe Ser Glu Pro Leu Tyr 
                485                 490                 495     


Pro Val Phe Arg Ile Leu Thr Leu Glu Pro Thr Ala Leu Thr Ile Cys 
            500                 505                 510         


Pro Ile Pro Lys Glu Val Glu Ser Ser Pro Asp Pro Asp Leu Val Pro 
        515                 520                 525             


Asp His Ser Leu Glu Thr Pro Leu Thr Pro Gly Leu Ala Asn Glu Ser 
    530                 535                 540                 


Gly Glu Pro Gln Ala Glu Val Thr Ser Leu Leu Leu Pro Ala His Pro 
545                 550                 555                 560 


Gly Ala Glu Val Ser Pro Ser Ala Thr Thr Asn Gln Asn His Lys Leu 
                565                 570                 575     


Gln Ala Arg Thr Glu Ala Leu Tyr 
            580                 


<210>  3609
<211>  523
<212>  PRT
<213>  Homo sapiens

<400>  3609

Met Glu Pro Ala Ala Ala Leu His Phe Ser Leu Pro Ala Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Ala 
            20                  25                  30          


Gln Phe Thr Val Val Gly Pro Ala Asn Pro Ile Leu Ala Met Val Gly 
        35                  40                  45              


Glu Asn Thr Thr Leu Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu 
    50                  55                  60                  


Asp Met Glu Val Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe 
65                  70                  75                  80  


Val Tyr Lys Gly Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr 
                85                  90                  95      


Arg Gly Arg Ile Thr Phe Val Ser Lys Asp Ile Asn Arg Gly Ser Val 
            100                 105                 110         


Ala Leu Val Ile His Asn Val Thr Ala Gln Glu Asn Gly Ile Tyr Arg 
        115                 120                 125             


Cys Tyr Phe Gln Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu Arg Leu 
    130                 135                 140                 


Val Val Ala Gly Leu Gly Ser Lys Pro Leu Ile Glu Ile Lys Ala Gln 
145                 150                 155                 160 


Glu Asp Gly Ser Ile Trp Leu Glu Cys Ile Ser Gly Gly Trp Tyr Pro 
                165                 170                 175     


Glu Pro Leu Thr Val Trp Arg Asp Pro Tyr Gly Glu Val Val Pro Ala 
            180                 185                 190         


Leu Lys Glu Val Ser Ile Ala Asp Ala Asp Gly Leu Phe Met Val Thr 
        195                 200                 205             


Thr Ala Val Ile Ile Arg Asp Lys Tyr Val Arg Asn Val Ser Cys Ser 
    210                 215                 220                 


Val Asn Asn Thr Leu Leu Gly Gln Glu Lys Glu Thr Val Ile Phe Ile 
225                 230                 235                 240 


Pro Glu Ser Phe Met Pro Ser Ala Ser Pro Trp Met Val Ala Leu Ala 
                245                 250                 255     


Val Ile Leu Thr Ala Ser Pro Trp Met Val Ser Met Thr Val Ile Leu 
            260                 265                 270         


Ala Val Phe Ile Ile Phe Met Ala Val Ser Ile Cys Cys Ile Lys Lys 
        275                 280                 285             


Leu Gln Arg Glu Lys Lys Ile Leu Ser Gly Glu Lys Lys Val Glu Gln 
    290                 295                 300                 


Glu Glu Lys Glu Ile Ala Gln Gln Leu Gln Glu Glu Leu Arg Trp Arg 
305                 310                 315                 320 


Arg Thr Phe Leu His Ala Ala Asp Val Val Leu Asp Pro Asp Thr Ala 
                325                 330                 335     


His Pro Glu Leu Phe Leu Ser Glu Asp Arg Arg Ser Val Arg Arg Gly 
            340                 345                 350         


Pro Tyr Arg Gln Arg Val Pro Asp Asn Pro Glu Arg Phe Asp Ser Gln 
        355                 360                 365             


Pro Cys Val Leu Gly Trp Glu Ser Phe Ala Ser Gly Lys His Tyr Trp 
    370                 375                 380                 


Glu Val Glu Val Glu Asn Val Met Val Trp Thr Val Gly Val Cys Arg 
385                 390                 395                 400 


His Ser Val Glu Arg Lys Gly Glu Val Leu Leu Ile Pro Gln Asn Gly 
                405                 410                 415     


Phe Trp Thr Leu Glu Met Phe Gly Asn Gln Tyr Arg Ala Leu Ser Ser 
            420                 425                 430         


Pro Glu Arg Ile Leu Pro Leu Lys Glu Ser Leu Cys Arg Val Gly Val 
        435                 440                 445             


Phe Leu Asp Tyr Glu Ala Gly Asp Val Ser Phe Tyr Asn Met Arg Asp 
    450                 455                 460                 


Arg Ser His Ile Tyr Thr Cys Pro Arg Ser Ala Phe Thr Val Pro Val 
465                 470                 475                 480 


Arg Pro Phe Phe Arg Leu Gly Ser Asp Asp Ser Pro Ile Phe Ile Cys 
                485                 490                 495     


Pro Ala Leu Thr Gly Ala Ser Gly Val Met Val Pro Glu Glu Gly Leu 
            500                 505                 510         


Lys Leu His Arg Val Gly Thr His Gln Ser Leu 
        515                 520             


<210>  3610
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  3610

Met Asp Val Pro Gly Pro Val Ser Arg Arg Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Thr Val Leu Leu Arg Thr Ala Arg Val Arg Arg Glu Cys Trp Phe Leu 
            20                  25                  30          


Pro Thr Ala Leu Leu Cys Ala Tyr Gly Phe Phe Ala Ser Leu Arg Pro 
        35                  40                  45              


Ser Glu Pro Phe Leu Thr Pro Tyr Leu Leu Gly Pro Asp Lys Asn Leu 
    50                  55                  60                  


Thr Glu Arg Glu Val Phe Asn Glu Ile Tyr Pro Val Trp Thr Tyr Ser 
65                  70                  75                  80  


Tyr Leu Val Leu Leu Phe Pro Val Phe Leu Ala Thr Asp Tyr Leu Arg 
                85                  90                  95      


Tyr Lys Pro Val Val Leu Leu Gln Gly Leu Ser Leu Ile Val Thr Trp 
            100                 105                 110         


Phe Met Leu Leu Tyr Ala Gln Gly Leu Leu Ala Ile Gln Phe Leu Glu 
        115                 120                 125             


Phe Phe Tyr Gly Ile Ala Thr Ala Thr Glu Ile Ala Tyr Tyr Ser Tyr 
    130                 135                 140                 


Ile Tyr Ser Val Val Asp Leu Gly Met Tyr Gln Lys Val Thr Ser Tyr 
145                 150                 155                 160 


Cys Arg Ser Ala Thr Leu Val Gly Phe Thr Val Gly Ser Val Leu Gly 
                165                 170                 175     


Gln Ile Leu Val Ser Val Ala Gly Trp Ser Leu Phe Ser Leu Asn Val 
            180                 185                 190         


Ile Ser Leu Thr Cys Val Ser Val Ala Phe Ala Val Ala Trp Phe Leu 
        195                 200                 205             


Pro Met Pro Gln Lys Ser Leu Phe Phe His His Ile Pro Ser Thr Cys 
    210                 215                 220                 


Gln Arg Val Asn Gly Ile Lys Val Gln Asn Gly Gly Ile Val Thr Asp 
225                 230                 235                 240 


Thr Pro Ala Ser Asn His Leu Pro Gly Trp Glu Asp Ile Glu Ser Lys 
                245                 250                 255     


Ile Pro Leu Asn Met Glu Glu Pro Pro Val Glu Glu Pro Glu Pro Lys 
            260                 265                 270         


Pro Asp Arg Leu Leu Val Leu Lys Val Leu Trp Asn Asp Phe Leu Met 
        275                 280                 285             


Cys Tyr Ser Ser Arg Pro Leu Leu Cys Trp Ser Val Trp Trp Ala Leu 
    290                 295                 300                 


Ser Thr Cys Gly Tyr Phe Gln Val Val Asn Tyr Thr Gln Gly Leu Trp 
305                 310                 315                 320 


Glu Lys Val Met Pro Ser Arg Tyr Ala Ala Ile Tyr Asn Gly Gly Val 
                325                 330                 335     


Glu Ala Val Ser Thr Leu Leu Gly Ala Val Ala Val Phe Ala Val Gly 
            340                 345                 350         


Tyr Ile Lys Ile Ser Trp Ser Thr Trp Gly Glu Met Thr Leu Ser Leu 
        355                 360                 365             


Phe Ser Leu Leu Ile Ala Ala Ala Val Tyr Ile Met Asp Thr Val Gly 
    370                 375                 380                 


Asn Ile Trp Val Cys Tyr Ala Ser Tyr Val Val Phe Arg Ile Ile Tyr 
385                 390                 395                 400 


Met Leu Leu Ile Thr Ile Ala Thr Phe Gln Ile Ala Ala Asn Leu Ser 
                405                 410                 415     


Met Glu Arg Tyr Ala Leu Val Phe Gly Val Asn Thr Phe Ile Ala Leu 
            420                 425                 430         


Ala Leu Gln Thr Leu Leu Thr Leu Ile Val Val Asp Ala Ser Gly Leu 
        435                 440                 445             


Gly Leu Glu Ile Thr Thr Gln Phe Leu Ile Tyr Ala Ser Tyr Phe Ala 
    450                 455                 460                 


Leu Ile Ala Val Val Phe Leu Ala Ser Gly Ala Val Ser Val Met Lys 
465                 470                 475                 480 


Lys Cys Arg Lys Leu Glu Asp Pro Gln Ser Ser Ser Gln Val Thr Thr 
                485                 490                 495     


Ser 
    


<210>  3611
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  3611

Met Ala Ser Ala Ala Ala Ala Glu Ala Glu Lys Gly Ser Pro Val Val 
1               5                   10                  15      


Val Gly Leu Leu Val Val Gly Asn Ile Ile Ile Leu Leu Ser Gly Leu 
            20                  25                  30          


Ser Leu Phe Ala Glu Thr Ile Trp Val Thr Ala Asp Gln Tyr Arg Val 
        35                  40                  45              


Tyr Pro Leu Met Gly Val Ser Gly Lys Asp Asp Val Phe Ala Gly Ala 
    50                  55                  60                  


Trp Ile Ala Ile Phe Cys Gly Phe Ser Phe Phe Met Val Ala Ser Phe 
65                  70                  75                  80  


Gly Val Gly Ala Ala Leu Cys Arg Arg Arg Ser Met Val Leu Thr Tyr 
                85                  90                  95      


Leu Val Leu Met Leu Ile Val Tyr Ile Phe Glu Cys Ala Ser Cys Ile 
            100                 105                 110         


Thr Ser Tyr Thr His Arg Asp Tyr Met Val Ser Asn Pro Ser Leu Ile 
        115                 120                 125             


Thr Lys Gln Met Leu Thr Phe Tyr Ser Ala Asp Thr Asp Gln Gly Gln 
    130                 135                 140                 


Glu Leu Thr Arg Leu Trp Asp Arg Val Met Ile Glu Gln Glu Cys Cys 
145                 150                 155                 160 


Gly Thr Ser Gly Pro Met Asp Trp Val Asn Phe Thr Ser Ala Phe Arg 
                165                 170                 175     


Ala Ala Thr Pro Glu Val Val Phe Pro Trp Pro Pro Leu Cys Cys Arg 
            180                 185                 190         


Arg Thr Gly Asn Phe Ile Pro Leu Asn Glu Glu Gly Cys Arg Leu Gly 
        195                 200                 205             


His Met Asp Tyr Leu Phe Thr Lys Gly Cys Phe Glu His Ile Gly His 
    210                 215                 220                 


Ala Ile Asp Ser Tyr Thr Trp Gly Ile Ser Trp Phe Gly Phe Ala Ile 
225                 230                 235                 240 


Leu Met Trp Thr Leu Pro Val Met Leu Ile Ala Met Tyr Phe Tyr Thr 
                245                 250                 255     


Met Leu 
        


<210>  3612
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  3612

Met Thr Ala Gly Gly Gln Ala Glu Ala Glu Gly Ala Gly Gly Glu Pro 
1               5                   10                  15      


Gly Ala Ala Arg Leu Pro Ser Arg Val Ala Arg Leu Leu Ser Ala Leu 
            20                  25                  30          


Phe Tyr Gly Thr Cys Ser Phe Leu Ile Val Leu Val Asn Lys Ala Leu 
        35                  40                  45              


Leu Thr Thr Tyr Gly Phe Pro Ser Pro Ile Phe Leu Gly Ile Gly Gln 
    50                  55                  60                  


Met Ala Ala Thr Ile Met Ile Leu Tyr Val Ser Lys Leu Asn Lys Ile 
65                  70                  75                  80  


Ile His Phe Pro Asp Phe Asp Lys Lys Ile Pro Val Lys Leu Phe Pro 
                85                  90                  95      


Leu Pro Leu Leu Tyr Val Gly Asn His Ile Ser Gly Leu Ser Ser Thr 
            100                 105                 110         


Ser Lys Leu Ser Leu Pro Met Phe Thr Val Leu Arg Lys Phe Thr Ile 
        115                 120                 125             


Pro Leu Thr Leu Leu Leu Glu Thr Ile Ile Leu Gly Lys Gln Tyr Ser 
    130                 135                 140                 


Leu Asn Ile Ile Leu Ser Val Phe Ala Ile Ile Leu Gly Ala Phe Ile 
145                 150                 155                 160 


Ala Ala Gly Ser Asp Leu Ala Phe Asn Leu Glu Gly Tyr Ile Phe Val 
                165                 170                 175     


Phe Leu Asn Asp Ile Phe Thr Ala Ala Asn Gly Val Tyr Thr Lys Gln 
            180                 185                 190         


Lys Met Asp Pro Lys Glu Leu Gly Lys Tyr Gly Val Leu Phe Tyr Asn 
        195                 200                 205             


Ala Cys Phe Met Ile Ile Pro Thr Leu Ile Ile Ser Val Ser Thr Gly 
    210                 215                 220                 


Asp Leu Gln Gln Ala Thr Glu Phe Asn Gln Trp Lys Asn Val Val Phe 
225                 230                 235                 240 


Ile Leu Gln Phe Leu Leu Ser Cys Phe Leu Gly Phe Leu Leu Met Tyr 
                245                 250                 255     


Ser Thr Val Leu Cys Ser Tyr Tyr Asn Ser Ala Leu Thr Thr Ala Val 
            260                 265                 270         


Val Gly Ala Ile Lys Asn Val Ser Val Ala Tyr Ile Gly Ile Leu Ile 
        275                 280                 285             


Gly Gly Asp Tyr Ile Phe Ser Leu Leu Asn Phe Val Gly Leu Asn Ile 
    290                 295                 300                 


Cys Met Ala Gly Gly Leu Arg Tyr Ser Phe Leu Thr Leu Ser Ser Gln 
305                 310                 315                 320 


Leu Lys Pro Lys Pro Val Gly Glu Glu Asn Ile Cys Leu Asp Leu Lys 
                325                 330                 335     


Ser 
    


<210>  3613
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  3613

Met Asp Gly Gln Lys Lys Asn Trp Lys Asp Lys Val Val Asp Leu Leu 
1               5                   10                  15      


Tyr Trp Arg Asp Ile Lys Lys Thr Gly Val Val Phe Gly Ala Ser Leu 
            20                  25                  30          


Phe Leu Leu Leu Ser Leu Thr Val Phe Ser Ile Val Ser Val Thr Ala 
        35                  40                  45              


Tyr Ile Ala Leu Ala Leu Leu Ser Val Thr Ile Ser Phe Arg Ile Tyr 
    50                  55                  60                  


Lys Gly Val Ile Gln Ala Ile Gln Lys Ser Asp Glu Gly His Pro Phe 
65                  70                  75                  80  


Arg Ala Tyr Leu Glu Ser Glu Val Ala Ile Ser Glu Glu Leu Val Gln 
                85                  90                  95      


Lys Tyr Ser Asn Ser Ala Leu Gly His Val Asn Cys Thr Ile Lys Glu 
            100                 105                 110         


Leu Arg Arg Leu Phe Leu Val Asp Asp Leu Val Asp Ser Leu Lys Phe 
        115                 120                 125             


Ala Val Leu Met Trp Val Phe Thr Tyr Val Gly Ala Leu Phe Asn Gly 
    130                 135                 140                 


Leu Thr Leu Leu Ile Leu Ala Leu Ile Ser Leu Phe Ser Val Pro Val 
145                 150                 155                 160 


Ile Tyr Glu Arg His Gln Ala Gln Ile Asp His Tyr Leu Gly Leu Ala 
                165                 170                 175     


Asn Lys Asn Val Lys Asp Ala Met Ala Lys Ile Gln Ala Lys Ile Pro 
            180                 185                 190         


Gly Leu Lys Arg Lys Ala Glu 
        195                 


<210>  3614
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  3614

Met Glu Ala Phe Ala Leu Gly Pro Ala Arg Arg Gly Arg Arg Arg Thr 
1               5                   10                  15      


Arg Ala Ala Gly Ser Leu Leu Ser Arg Ala Ala Ile Leu Leu Phe Ile 
            20                  25                  30          


Ser Ala Phe Leu Val Arg Val Pro Ser Ser Val Gly His Leu Val Arg 
        35                  40                  45              


Leu Pro Arg Ala Phe Arg Leu Thr Lys Asp Ser Val Lys Ile Val Gly 
    50                  55                  60                  


Ser Thr Ser Phe Pro Val Lys Ala Tyr Val Met Leu His Gln Lys Ser 
65                  70                  75                  80  


Pro His Val Leu Cys Val Thr Gln Gln Leu Arg Asn Ala Glu Leu Ile 
                85                  90                  95      


Asp Pro Ser Phe Gln Trp Tyr Gly Pro Lys Gly Lys Val Val Ser Val 
            100                 105                 110         


Glu Asn Arg Thr Ala Gln Ile Thr Ser Thr Gly Ser Leu Val Phe Gln 
        115                 120                 125             


Asn Phe Glu Glu Ser Met Ser Gly Ile Tyr Thr Cys Phe Leu Glu Tyr 
    130                 135                 140                 


Lys Pro Thr Val Glu Glu Ile Val Lys Arg Leu Gln Leu Lys Tyr Ala 
145                 150                 155                 160 


Ile Tyr Ala Tyr Arg Glu Pro His Tyr Tyr Tyr Gln Phe Thr Ala Arg 
                165                 170                 175     


Tyr His Ala Ala Pro Cys Asn Ser Ile Tyr Asn Ile Ser Phe Glu Lys 
            180                 185                 190         


Lys Leu Leu Gln Ile Leu Ser Lys Leu Leu Leu Asp Leu Ser Cys Glu 
        195                 200                 205             


Ile Ser Leu Leu Lys Ser Glu Cys His Arg Val Lys Met Gln Arg Ala 
    210                 215                 220                 


Gly Leu Gln Asn Glu Leu Phe Phe Ala Phe Ser Val Ser Ser Leu Asp 
225                 230                 235                 240 


Thr Glu Lys Gly Pro Lys Arg Cys Thr Asp His Asn Cys Glu Pro Tyr 
                245                 250                 255     


Lys Arg Leu Phe Lys Ala Lys Asn Leu Ile Glu Arg Phe Phe Asn Gln 
            260                 265                 270         


Gln Val Glu Ile Leu Gly Arg Arg Ala Glu Gln Leu Pro Gln Ile Tyr 
        275                 280                 285             


Tyr Ile Glu Gly Thr Leu Gln Met Val Trp Ile Asn Arg Cys Phe Pro 
    290                 295                 300                 


Gly Tyr Gly Met Asn Val Gln Gln His Pro Lys Cys Pro Glu Cys Cys 
305                 310                 315                 320 


Val Ile Cys Ser Pro Gly Ser Tyr Asn Pro Arg Asp Gly Ile His Cys 
                325                 330                 335     


Leu Gln Cys Asn Ser Ser Leu Val Tyr Gly Ala Lys Thr Cys Leu 
            340                 345                 350     


<210>  3615
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  3615

Met Thr Glu Asn Ser Asp Lys Val Pro Ile Ala Leu Val Gly Pro Asp 
1               5                   10                  15      


Asp Val Glu Phe Cys Ser Pro Pro Ala Tyr Ala Thr Leu Thr Val Lys 
            20                  25                  30          


Pro Ser Ser Pro Ala Arg Leu Leu Lys Val Gly Ala Val Val Leu Ile 
        35                  40                  45              


Ser Gly Ala Val Leu Leu Leu Phe Gly Ala Ile Gly Ala Phe Tyr Phe 
    50                  55                  60                  


Trp Lys Gly Ser Asp Ser His Ile Tyr Asn Val His Tyr Thr Met Ser 
65                  70                  75                  80  


Ile Asn Gly Lys Leu Gln Asp Gly Ser Met Glu Ile Asp Ala Gly Asn 
                85                  90                  95      


Asn Leu Glu Thr Phe Lys Met Gly Ser Gly Ala Glu Glu Ala Ile Ala 
            100                 105                 110         


Val Asn Asp Phe Gln Asn Gly Ile Thr Gly Ile Arg Phe Ala Gly Gly 
        115                 120                 125             


Glu Lys Cys Tyr Ile Lys Ala Gln Val Lys Ala Arg Ile Pro Glu Val 
    130                 135                 140                 


Gly Ala Val Thr Lys Gln Ser Ile Ser Ser Lys Leu Glu Gly Lys Ile 
145                 150                 155                 160 


Met Pro Val Lys Tyr Glu Glu Asn Ser Leu Ile Trp Val Ala Val Asp 
                165                 170                 175     


Gln Pro Val Lys Asp Asn Ser Phe Leu Ser Ser Lys Val Leu Glu Leu 
            180                 185                 190         


Cys Gly Asp Leu Pro Ile Phe Trp Leu Lys Pro Thr Tyr Pro Lys Glu 
        195                 200                 205             


Ile Gln Arg Glu Arg Arg Glu Val Val Arg Lys Ile Val Pro Thr Thr 
    210                 215                 220                 


Thr Lys Arg Pro His Ser Gly Pro Arg Ser Asn Pro Gly Ala Gly Arg 
225                 230                 235                 240 


Leu Asn Asn Glu Thr Arg Pro Ser Val Gln Glu Asp Ser Gln Ala Phe 
                245                 250                 255     


Asn Pro Asp Asn Pro Tyr His Gln Gln Glu Gly Glu Ser Met Thr Phe 
            260                 265                 270         


Asp Pro Arg Leu Asp His Glu Gly Ile Cys Cys Ile Glu Cys Arg Arg 
        275                 280                 285             


Ser Tyr Thr His Cys Gln Lys Ile Cys Glu Pro Leu Gly Gly Tyr Tyr 
    290                 295                 300                 


Pro Trp Pro Tyr Asn Tyr Gln Gly Cys Arg Ser Ala Cys Arg Val Ile 
305                 310                 315                 320 


Met Pro Cys Ser Trp Trp Val Ala Arg Ile Leu Gly Met Val 
                325                 330                 


<210>  3616
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  3616

Met Ala Leu Ser Ala Glu Thr Glu Ser His Ile Tyr Arg Ala Leu Arg 
1               5                   10                  15      


Thr Ala Ser Gly Ala Ala Ala His Leu Val Ala Leu Gly Phe Thr Ile 
            20                  25                  30          


Phe Val Ala Val Leu Ala Arg Pro Gly Ser Ser Leu Phe Ser Trp His 
        35                  40                  45              


Pro Val Leu Met Ser Leu Ala Phe Ser Phe Leu Met Thr Glu Ala Leu 
    50                  55                  60                  


Leu Val Phe Ser Pro Glu Ser Ser Leu Leu His Ser Leu Ser Arg Lys 
65                  70                  75                  80  


Gly Arg Ala Arg Cys His Trp Val Leu Gln Leu Leu Ala Leu Leu Cys 
                85                  90                  95      


Ala Leu Leu Gly Leu Gly Leu Val Ile Leu His Lys Glu Gln Leu Gly 
            100                 105                 110         


Lys Ala His Leu Val Thr Arg His Gly Gln Ala Gly Leu Leu Ala Val 
        115                 120                 125             


Leu Trp Ala Gly Leu Gln Cys Ser Gly Gly Val Gly Leu Leu Tyr Pro 
    130                 135                 140                 


Lys Leu Leu Pro Arg Trp Pro Leu Ala Lys Leu Lys Leu Tyr His Ala 
145                 150                 155                 160 


Thr Ser Gly Leu Val Gly Tyr Leu Leu Gly Ser Ala Ser Leu Leu Leu 
                165                 170                 175     


Gly Met Cys Ser Leu Trp Phe Thr Ala Ser Val Thr Gly Ala Ala Trp 
            180                 185                 190         


Tyr Leu Ala Val Leu Cys Pro Val Leu Thr Ser Leu Val Ile Met Asn 
        195                 200                 205             


Gln Val Ser Asn Ala Tyr Leu Tyr Arg Lys Arg Ile Gln Pro 
    210                 215                 220         


<210>  3617
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  3617

Met Gln Arg Ala Leu Pro Gly Ala Arg Gln His Leu Gly Ala Ile Leu 
1               5                   10                  15      


Ala Ser Ala Ser Val Val Val Lys Ala Leu Cys Ala Ala Val Leu Phe 
            20                  25                  30          


Leu Tyr Leu Leu Ser Phe Ala Val Asp Thr Gly Cys Leu Ala Val Thr 
        35                  40                  45              


Pro Gly Tyr Leu Phe Pro Pro Asn Phe Trp Ile Trp Thr Leu Ala Thr 
    50                  55                  60                  


His Gly Leu Met Glu Gln His Val Trp Asp Val Ala Ile Ser Leu Thr 
65                  70                  75                  80  


Thr Val Val Val Ala Gly Arg Leu Leu Glu Pro Leu Trp Gly Ala Leu 
                85                  90                  95      


Glu Leu Leu Ile Phe Phe Ser Val Val Asn Val Ser Val Gly Leu Leu 
            100                 105                 110         


Gly Ala Phe Ala Tyr Leu Leu Thr Tyr Met Ala Ser Phe Asn Leu Val 
        115                 120                 125             


Tyr Leu Phe Thr Val Arg Ile His Gly Ala Leu Gly Phe Leu Gly Gly 
    130                 135                 140                 


Val Leu Val Ala Leu Lys Gln Thr Met Gly Asp Cys Val Val Leu Arg 
145                 150                 155                 160 


Val Pro Gln Val Arg Val Ser Val Met Pro Met Leu Leu Leu Ala Leu 
                165                 170                 175     


Leu Leu Leu Leu Arg Leu Ala Thr Leu Leu Gln Ser Pro Ala Leu Ala 
            180                 185                 190         


Ser Tyr Gly Phe Gly Leu Leu Ser Ser Trp Val Tyr Leu Arg Phe Tyr 
        195                 200                 205             


Gln Arg His Ser Arg Gly Arg Gly Asp Met Ala Asp His Phe Ala Phe 
    210                 215                 220                 


Ala Thr Phe Phe Pro Glu Ile Leu Gln Pro Val Val Gly Leu Leu Ala 
225                 230                 235                 240 


Asn Leu Val His Ser Leu Leu Val Lys Val Lys Ile Cys Gln Lys Thr 
                245                 250                 255     


Val Lys Arg Tyr Asp Val Gly Ala Pro Ser Ser Ile Thr Ile Ser Leu 
            260                 265                 270         


Pro Gly Thr Asp Pro Gln Asp Ala Glu Arg Arg Arg Gln Leu Ala Leu 
        275                 280                 285             


Lys Ala Leu Asn Glu Arg Leu Lys Arg Val Glu Asp Gln Ser Ile Trp 
    290                 295                 300                 


Pro Ser Met Asp Asp Asp Glu Glu Glu Ser Gly Ala Lys Val Asp Ser 
305                 310                 315                 320 


Pro Leu Pro Ser Asp Lys Ala Pro Thr Pro Pro Gly Lys Gly Ala Ala 
                325                 330                 335     


Pro Glu Ser Ser Leu Ile Thr Phe Glu Ala Ala Pro Pro Thr Leu 
            340                 345                 350     


<210>  3618
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  3618

Met Ser Glu Gly Asp Ser Val Gly Glu Ser Val His Gly Lys Pro Ser 
1               5                   10                  15      


Val Val Tyr Arg Phe Phe Thr Arg Leu Gly Gln Ile Tyr Gln Ser Trp 
            20                  25                  30          


Leu Asp Lys Ser Thr Pro Tyr Thr Ala Val Arg Trp Val Val Thr Leu 
        35                  40                  45              


Gly Leu Ser Phe Val Tyr Met Ile Arg Val Tyr Leu Leu Gln Gly Trp 
    50                  55                  60                  


Tyr Ile Val Thr Tyr Ala Leu Gly Ile Tyr His Leu Asn Leu Phe Ile 
65                  70                  75                  80  


Ala Phe Leu Ser Pro Lys Val Asp Pro Ser Leu Met Glu Asp Ser Asp 
                85                  90                  95      


Asp Gly Pro Ser Leu Pro Thr Lys Gln Asn Glu Glu Phe Arg Pro Phe 
            100                 105                 110         


Ile Arg Arg Leu Pro Glu Phe Lys Phe Trp His Ala Ala Thr Lys Gly 
        115                 120                 125             


Ile Leu Val Ala Met Val Cys Thr Phe Phe Asp Ala Phe Asn Val Pro 
    130                 135                 140                 


Val Phe Trp Pro Ile Leu Val Met Tyr Phe Ile Met Leu Phe Cys Ile 
145                 150                 155                 160 


Thr Met Lys Arg Gln Ile Lys His Met Ile Lys Tyr Arg Tyr Ile Pro 
                165                 170                 175     


Phe Thr His Gly Lys Arg Arg Tyr Arg Gly Lys Glu Asp Ala Gly Lys 
            180                 185                 190         


Ala Phe Ala Ser 
        195     


<210>  3619
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  3619

Met Lys Met Ala Ser Ser Leu Ala Phe Leu Leu Leu Asn Phe His Val 
1               5                   10                  15      


Ser Leu Leu Leu Val Gln Leu Leu Thr Pro Cys Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Ala Leu Gly Ser Asn Leu His Val Glu Val Lys Gly Tyr Glu Asp Gly 
145                 150                 155                 160 


Gly Ile His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln 
                165                 170                 175     


Ile Gln Trp Ser Asn Ala Lys Gly Glu Asn Ile Pro Ala Val Glu Ala 
            180                 185                 190         


Pro Val Val Ala Asp Gly Val Gly Leu Tyr Glu Val Ala Ala Ser Val 
        195                 200                 205             


Ile Met Arg Gly Gly Ser Gly Glu Gly Val Ser Cys Ile Ile Arg Asn 
    210                 215                 220                 


Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro 
225                 230                 235                 240 


Phe Phe Arg Ser Ala Gln Pro Trp Ile Ala Ala Leu Ala Gly Thr Leu 
                245                 250                 255     


Pro Ile Leu Leu Leu Leu Leu Ala Gly Ala Ser Tyr Phe Leu Trp Arg 
            260                 265                 270         


Gln Gln Lys Glu Ile Thr Ala Leu Ser Ser Glu Ile Glu Ser Glu Gln 
        275                 280                 285             


Glu Met Lys Glu Met Gly Tyr Ala Ala Thr Glu Arg Glu Ile Ser Leu 
    290                 295                 300                 


Arg Glu Ser Leu Gln Glu Glu Leu Lys Arg Lys Lys Ile Gln Tyr Leu 
305                 310                 315                 320 


Thr Arg Gly Glu Glu Ser Ser Ser Asp Thr Asn Lys Ser Ala 
                325                 330                 


<210>  3620
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  3620

Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val 
1               5                   10                  15      


Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Ala Leu Gly Ser Asp Leu His Val Asp Val Lys Gly Tyr Lys Asp Gly 
145                 150                 155                 160 


Gly Ile His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln 
                165                 170                 175     


Ile Gln Trp Ser Asn Asn Lys Gly Glu Asn Ile Pro Thr Val Glu Ala 
            180                 185                 190         


Pro Val Val Ala Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val 
        195                 200                 205             


Ile Met Arg Gly Ser Ser Gly Glu Gly Val Ser Cys Thr Ile Arg Ser 
    210                 215                 220                 


Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro 
225                 230                 235                 240 


Phe Phe Arg Ser Ala Gln Arg Trp Ile Ala Ala Leu Ala Gly Thr Leu 
                245                 250                 255     


Pro Val Leu Leu Leu Leu Leu Gly Gly Ala Gly Tyr Phe Leu Trp Gln 
            260                 265                 270         


Gln Gln Glu Glu Lys Lys Thr Gln Phe Arg Lys Lys Lys Arg Glu Gln 
        275                 280                 285             


Glu Leu Arg Glu Met Ala Trp Ser Thr Met Lys Gln Glu Gln Ser Thr 
    290                 295                 300                 


Arg Val Lys Leu Leu Glu Glu Leu Arg Trp Arg Ser Ile Gln Tyr Ala 
305                 310                 315                 320 


Ser Arg Gly Glu Arg His Ser Ala Tyr Asn Glu Trp Lys Lys Ala Leu 
                325                 330                 335     


Phe Lys Pro Ala Asp Val Ile Leu Asp Pro Lys Thr Ala Asn Pro Ile 
            340                 345                 350         


Leu Leu Val Ser Glu Asp Gln Arg Ser Val Gln Arg Ala Lys Glu Pro 
        355                 360                 365             


Gln Asp Leu Pro Asp Asn Pro Glu Arg Phe Asn Trp His Tyr Cys Val 
    370                 375                 380                 


Leu Gly Cys Glu Ser Phe Ile Ser Gly Arg His Tyr Trp Glu Val Glu 
385                 390                 395                 400 


Val Gly Asp Arg Lys Glu Trp His Ile Gly Val Cys Ser Lys Asn Val 
                405                 410                 415     


Gln Arg Lys Gly Trp Val Lys Met Thr Pro Glu Asn Gly Phe Trp Thr 
            420                 425                 430         


Met Gly Leu Thr Asp Gly Asn Lys Tyr Arg Thr Leu Thr Glu Pro Arg 
        435                 440                 445             


Thr Asn Leu Lys Leu Pro Lys Pro Pro Lys Lys Val Gly Val Phe Leu 
    450                 455                 460                 


Asp Tyr Glu Thr Gly Asp Ile Ser Phe Tyr Asn Ala Val Asp Gly Ser 
465                 470                 475                 480 


His Ile His Thr Phe Leu Asp Val Ser Phe Ser Glu Ala Leu Tyr Pro 
                485                 490                 495     


Val Phe Arg Ile Leu Thr Leu Glu Pro Thr Ala Leu Thr Ile Cys Pro 
            500                 505                 510         


Ala 
    


<210>  3621
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  3621

Met Glu Ser Ala Ala Ala Leu His Phe Ser Arg Pro Ala Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Ala Gln Phe Ile Val 
            20                  25                  30          


Val Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr 
        35                  40                  45              


Leu Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val 
    50                  55                  60                  


Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly 
65                  70                  75                  80  


Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr 
                85                  90                  95      


Thr Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile 
            100                 105                 110         


His Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln 
        115                 120                 125             


Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Val Ala Gly 
    130                 135                 140                 


Leu Gly Ser Lys Pro Leu Ile Ser Met Arg Gly His Glu Asp Gly Gly 
145                 150                 155                 160 


Ile Arg Leu Glu Cys Ile Ser Arg Gly Trp Tyr Pro Lys Pro Leu Thr 
                165                 170                 175     


Val Trp Arg Asp Pro Tyr Gly Gly Val Ala Pro Ala Leu Lys Glu Val 
            180                 185                 190         


Ser Met Pro Asp Ala Asp Gly Leu Phe Met Val Thr Thr Ala Val Ile 
        195                 200                 205             


Ile Arg Asp Lys Ser Val Arg Asn Met Ser Cys Ser Ile Asn Asn Thr 
    210                 215                 220                 


Leu Leu Gly Gln Lys Lys Glu Ser Val Ile Phe Ile Pro Glu Ser Phe 
225                 230                 235                 240 


Met Pro Ser Val Ser Pro Cys Ala Val Ala Leu Pro Ile Ile Val Val 
                245                 250                 255     


Ile Leu Met Ile Pro Ile Ala Val Cys Ile Tyr Trp Ile Asn Lys Leu 
            260                 265                 270         


Gln Lys Glu Lys Lys Ile Leu Ser Gly Glu Lys Glu Phe Glu Arg Glu 
        275                 280                 285             


Thr Arg Glu Ile Ala Leu Lys Glu Leu Glu Lys Glu Arg Val Gln Lys 
    290                 295                 300                 


Glu Glu Glu Leu Gln Val Lys Glu Lys Leu Gln Glu Glu Leu Arg Trp 
305                 310                 315                 320 


Arg Arg Thr Phe Leu His Ala Val Asp Val Val Leu Asp Pro Asp Thr 
                325                 330                 335     


Ala His Pro Asp Leu Phe Leu Ser Glu Asp Arg Arg Ser Val Arg Arg 
            340                 345                 350         


Cys Pro Phe Arg His Leu Gly Glu Ser Val Pro Asp Asn Pro Glu Arg 
        355                 360                 365             


Phe Asp Ser Gln Pro Cys Val Leu Gly Arg Glu Ser Phe Ala Ser Gly 
    370                 375                 380                 


Lys His Tyr Trp Glu Val Glu Val Glu Asn Val Ile Glu Trp Thr Val 
385                 390                 395                 400 


Gly Val Cys Arg Asp Ser Val Glu Arg Lys Gly Glu Val Leu Leu Ile 
                405                 410                 415     


Pro Gln Asn Gly Phe Trp Thr Leu Glu Met His Lys Gly Gln Tyr Arg 
            420                 425                 430         


Ala Val Ser Ser Pro Asp Arg Ile Leu Pro Leu Lys Glu Ser Leu Cys 
        435                 440                 445             


Arg Val Gly Val Phe Leu Asp Tyr Glu Ala Gly Asp Val Ser Phe Tyr 
    450                 455                 460                 


Asn Met Arg Asp Arg Ser His Ile Tyr Thr Cys Pro Arg Ser Ala Phe 
465                 470                 475                 480 


Ser Val Pro Val Arg Pro Phe Phe Arg Leu Gly Cys Glu Asp Ser Pro 
                485                 490                 495     


Ile Phe Ile Cys Pro Ala Leu Thr Gly Ala Asn Gly Val Thr Val Pro 
            500                 505                 510         


Glu Glu Gly Leu Thr Leu His Arg Val Gly Thr His Gln Ser Leu 
        515                 520                 525         


<210>  3622
<211>  1441
<212>  PRT
<213>  Homo sapiens

<400>  3622

Met Ala Ser Leu Ala Ala Leu Ala Leu Ser Leu Leu Leu Arg Leu Gln 
1               5                   10                  15      


Leu Pro Pro Leu Pro Gly Ala Arg Ala Gln Ser Ala Ala Gly Gly Cys 
            20                  25                  30          


Ser Phe Asp Glu His Tyr Ser Asn Cys Gly Tyr Ser Val Ala Leu Gly 
        35                  40                  45              


Thr Asn Gly Phe Thr Trp Glu Gln Ile Asn Thr Trp Glu Lys Pro Met 
    50                  55                  60                  


Leu Asp Gln Ala Val Pro Thr Gly Ser Phe Met Met Val Asn Ser Ser 
65                  70                  75                  80  


Gly Arg Ala Ser Gly Gln Lys Ala His Leu Leu Leu Pro Thr Leu Lys 
                85                  90                  95      


Glu Asn Asp Thr His Cys Ile Asp Phe His Tyr Tyr Phe Ser Ser Arg 
            100                 105                 110         


Asp Arg Ser Ser Pro Gly Ala Leu Asn Val Tyr Val Lys Val Asn Gly 
        115                 120                 125             


Gly Pro Gln Gly Asn Pro Val Trp Asn Val Ser Gly Val Val Thr Glu 
    130                 135                 140                 


Gly Trp Val Lys Ala Glu Leu Ala Ile Ser Thr Phe Trp Pro His Phe 
145                 150                 155                 160 


Tyr Gln Val Ile Phe Glu Ser Val Ser Leu Lys Gly His Pro Gly Tyr 
                165                 170                 175     


Ile Ala Val Asp Glu Val Arg Val Leu Ala His Pro Cys Arg Lys Ala 
            180                 185                 190         


Pro His Phe Leu Arg Leu Gln Asn Val Glu Val Asn Val Gly Gln Asn 
        195                 200                 205             


Ala Thr Phe Gln Cys Ile Ala Gly Gly Lys Trp Ser Gln His Asp Lys 
    210                 215                 220                 


Leu Trp Leu Gln Gln Trp Asn Gly Arg Asp Thr Ala Leu Met Val Thr 
225                 230                 235                 240 


Arg Val Val Asn His Arg Arg Phe Ser Ala Thr Val Ser Val Ala Asp 
                245                 250                 255     


Thr Ala Gln Arg Ser Val Ser Lys Tyr Arg Cys Val Ile Arg Ser Asp 
            260                 265                 270         


Gly Gly Ser Gly Val Ser Asn Tyr Ala Glu Leu Ile Val Lys Glu Pro 
        275                 280                 285             


Pro Thr Pro Ile Ala Pro Pro Glu Leu Leu Ala Val Gly Ala Thr Tyr 
    290                 295                 300                 


Leu Trp Ile Lys Pro Asn Ala Asn Ser Ile Ile Gly Asp Gly Pro Ile 
305                 310                 315                 320 


Ile Leu Lys Glu Val Glu Tyr Arg Thr Thr Thr Gly Thr Trp Ala Glu 
                325                 330                 335     


Thr His Ile Val Asp Ser Pro Asn Tyr Lys Leu Trp His Leu Asp Pro 
            340                 345                 350         


Asp Val Glu Tyr Glu Ile Arg Val Leu Leu Thr Arg Pro Gly Glu Gly 
        355                 360                 365             


Gly Thr Gly Pro Pro Gly Pro Pro Leu Thr Thr Arg Thr Lys Cys Ala 
    370                 375                 380                 


Asp Pro Val His Gly Pro Gln Asn Val Glu Ile Val Asp Ile Arg Ala 
385                 390                 395                 400 


Arg Gln Leu Thr Leu Gln Trp Glu Pro Phe Gly Tyr Ala Val Thr Arg 
                405                 410                 415     


Cys His Ser Tyr Asn Leu Thr Val Gln Tyr Gln Tyr Val Phe Asn Gln 
            420                 425                 430         


Gln Gln Tyr Glu Ala Glu Glu Val Ile Gln Thr Ser Ser His Tyr Thr 
        435                 440                 445             


Leu Arg Gly Leu Arg Pro Phe Met Thr Ile Arg Leu Arg Leu Leu Leu 
    450                 455                 460                 


Ser Asn Pro Glu Gly Arg Met Glu Ser Glu Glu Leu Val Val Gln Thr 
465                 470                 475                 480 


Glu Glu Asp Val Pro Gly Ala Val Pro Leu Glu Ser Ile Gln Gly Gly 
                485                 490                 495     


Pro Phe Glu Glu Lys Ile Tyr Ile Gln Trp Lys Pro Pro Asn Glu Thr 
            500                 505                 510         


Asn Gly Val Ile Thr Leu Tyr Glu Ile Asn Tyr Lys Ala Val Gly Ser 
        515                 520                 525             


Leu Asp Pro Ser Ala Asp Leu Ser Ser Gln Arg Gly Lys Val Phe Lys 
    530                 535                 540                 


Leu Arg Asn Glu Thr His His Leu Phe Val Gly Leu Tyr Pro Gly Thr 
545                 550                 555                 560 


Thr Tyr Ser Phe Thr Ile Lys Ala Ser Thr Ala Lys Gly Phe Gly Pro 
                565                 570                 575     


Pro Val Thr Thr Arg Ile Ala Thr Lys Ile Ser Ala Pro Ser Met Pro 
            580                 585                 590         


Glu Tyr Asp Thr Asp Thr Pro Leu Asn Glu Thr Asp Thr Thr Ile Thr 
        595                 600                 605             


Val Met Leu Lys Pro Ala Gln Ser Arg Gly Ala Pro Val Ser Val Tyr 
    610                 615                 620                 


Gln Leu Val Val Lys Glu Glu Arg Leu Gln Lys Ser Arg Arg Ala Ala 
625                 630                 635                 640 


Asp Ile Ile Glu Cys Phe Ser Val Pro Val Ser Tyr Arg Asn Ala Ser 
                645                 650                 655     


Ser Leu Asp Ser Leu His Tyr Phe Ala Ala Glu Leu Lys Pro Ala Asn 
            660                 665                 670         


Leu Pro Val Thr Gln Pro Phe Thr Val Gly Asp Asn Lys Thr Tyr Asn 
        675                 680                 685             


Gly Tyr Trp Asn Pro Pro Leu Ser Pro Leu Lys Ser Tyr Ser Ile Tyr 
    690                 695                 700                 


Phe Gln Ala Leu Ser Lys Ala Asn Gly Glu Thr Lys Ile Asn Cys Val 
705                 710                 715                 720 


Arg Leu Ala Thr Lys Gly Ala Ser Thr Gln Asn Ser Asn Thr Val Glu 
                725                 730                 735     


Pro Glu Lys Gln Val Asp Asn Thr Val Lys Met Ala Gly Val Ile Ala 
            740                 745                 750         


Gly Leu Leu Met Phe Ile Ile Ile Leu Leu Gly Val Met Leu Thr Ile 
        755                 760                 765             


Lys Arg Arg Arg Asn Ala Tyr Ser Tyr Ser Tyr Tyr Leu Lys Leu Ala 
    770                 775                 780                 


Lys Lys Gln Lys Glu Thr Gln Ser Gly Ala Gln Arg Glu Met Gly Pro 
785                 790                 795                 800 


Val Ala Ser Ala Asp Lys Pro Thr Thr Lys Leu Ser Ala Ser Arg Asn 
                805                 810                 815     


Asp Glu Gly Phe Ser Ser Ser Ser Gln Asp Val Asn Gly Phe Thr Asp 
            820                 825                 830         


Gly Ser Arg Gly Glu Leu Ser Gln Pro Thr Leu Thr Ile Gln Thr His 
        835                 840                 845             


Pro Tyr Arg Thr Cys Asp Pro Val Glu Met Ser Tyr Pro Arg Asp Gln 
    850                 855                 860                 


Phe Gln Pro Ala Ile Arg Val Ala Asp Leu Leu Gln His Ile Thr Gln 
865                 870                 875                 880 


Met Lys Arg Gly Gln Gly Tyr Gly Phe Lys Glu Glu Tyr Glu Ala Leu 
                885                 890                 895     


Pro Glu Gly Gln Thr Ala Ser Trp Asp Thr Ala Lys Glu Asp Glu Asn 
            900                 905                 910         


Arg Asn Lys Asn Arg Tyr Gly Asn Ile Ile Ser Tyr Asp His Ser Arg 
        915                 920                 925             


Val Arg Leu Leu Val Leu Asp Gly Asp Pro His Ser Asp Tyr Ile Asn 
    930                 935                 940                 


Ala Asn Tyr Ile Asp Gly Tyr His Arg Pro Arg His Tyr Ile Ala Thr 
945                 950                 955                 960 


Gln Gly Pro Met Gln Glu Thr Val Lys Asp Phe Trp Arg Met Ile Trp 
                965                 970                 975     


Gln Glu Asn Ser Ala Ser Ile Val Met Val Thr Asn Leu Val Glu Val 
            980                 985                 990         


Gly Arg Val Lys Cys Val Arg Tyr  Trp Pro Asp Asp Thr  Glu Val Tyr 
        995                 1000                 1005             


Gly Asp  Ile Lys Val Thr Leu  Ile Glu Thr Glu Pro  Leu Ala Glu 
    1010                 1015                 1020             


Tyr Val  Ile Arg Thr Phe Thr  Val Gln Lys Lys Gly  Tyr His Glu 
    1025                 1030                 1035             


Ile Arg  Glu Leu Arg Leu Phe  His Phe Thr Ser Trp  Pro Asp His 
    1040                 1045                 1050             


Gly Val  Pro Cys Tyr Ala Thr  Gly Leu Leu Gly Phe  Val Arg Gln 
    1055                 1060                 1065             


Val Lys  Phe Leu Asn Pro Pro  Glu Ala Gly Pro Ile  Val Val His 
    1070                 1075                 1080             


Cys Ser  Ala Gly Ala Gly Arg  Thr Gly Cys Phe Ile  Ala Ile Asp 
    1085                 1090                 1095             


Thr Met  Leu Asp Met Ala Glu  Asn Glu Gly Val Val  Asp Ile Phe 
    1100                 1105                 1110             


Asn Cys  Val Arg Glu Leu Arg  Ala Gln Arg Val Asn  Leu Val Gln 
    1115                 1120                 1125             


Thr Glu  Glu Gln Tyr Val Phe  Val His Asp Ala Ile  Leu Glu Ala 
    1130                 1135                 1140             


Cys Leu  Cys Gly Asn Thr Ala  Ile Pro Val Cys Glu  Phe Arg Ser 
    1145                 1150                 1155             


Leu Tyr  Tyr Asn Ile Ser Arg  Leu Asp Pro Gln Thr  Asn Ser Ser 
    1160                 1165                 1170             


Gln Ile  Lys Asp Glu Phe Gln  Thr Leu Asn Ile Val  Thr Pro Arg 
    1175                 1180                 1185             


Val Arg  Pro Glu Asp Cys Ser  Ile Gly Leu Leu Pro  Arg Asn His 
    1190                 1195                 1200             


Asp Lys  Asn Arg Ser Met Asp  Val Leu Pro Leu Asp  Arg Cys Leu 
    1205                 1210                 1215             


Pro Phe  Leu Ile Ser Val Asp  Gly Glu Ser Ser Asn  Tyr Ile Asn 
    1220                 1225                 1230             


Ala Ala  Leu Met Asp Ser His  Lys Gln Pro Ala Ala  Phe Val Val 
    1235                 1240                 1245             


Thr Gln  His Pro Leu Pro Asn  Thr Val Ala Asp Phe  Trp Arg Leu 
    1250                 1255                 1260             


Val Phe  Asp Tyr Asn Cys Ser  Ser Val Val Met Leu  Asn Glu Met 
    1265                 1270                 1275             


Asp Thr  Ala Gln Phe Cys Met  Gln Tyr Trp Pro Glu  Lys Thr Ser 
    1280                 1285                 1290             


Gly Cys  Tyr Gly Pro Ile Gln  Val Glu Phe Val Ser  Ala Asp Ile 
    1295                 1300                 1305             


Asp Glu  Asp Ile Ile His Arg  Ile Phe Arg Ile Cys  Asn Met Ala 
    1310                 1315                 1320             


Arg Pro  Gln Asp Gly Tyr Arg  Ile Val Gln His Leu  Gln Tyr Ile 
    1325                 1330                 1335             


Gly Trp  Pro Ala Tyr Arg Asp  Thr Pro Pro Ser Lys  Arg Ser Leu 
    1340                 1345                 1350             


Leu Lys  Val Val Arg Arg Leu  Glu Lys Trp Gln Glu  Gln Tyr Asp 
    1355                 1360                 1365             


Gly Arg  Glu Gly Arg Thr Val  Val His Cys Leu Asn  Gly Gly Gly 
    1370                 1375                 1380             


Arg Ser  Gly Thr Phe Cys Ala  Ile Cys Ser Val Cys  Glu Met Ile 
    1385                 1390                 1395             


Gln Gln  Gln Asn Ile Ile Asp  Val Phe His Ile Val  Lys Thr Leu 
    1400                 1405                 1410             


Arg Asn  Asn Lys Ser Asn Met  Val Glu Thr Leu Glu  Gln Tyr Lys 
    1415                 1420                 1425             


Phe Val  Tyr Glu Val Ala Leu  Glu Tyr Leu Ser Ser  Phe 
    1430                 1435                 1440     


<210>  3623
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  3623

Met Gly Asn Trp Val Val Asn His Trp Phe Ser Val Leu Phe Leu Val 
1               5                   10                  15      


Val Trp Leu Gly Leu Asn Val Phe Leu Phe Val Asp Ala Phe Leu Lys 
            20                  25                  30          


Tyr Glu Lys Ala Asp Lys Tyr Tyr Tyr Thr Arg Lys Ile Leu Gly Ser 
        35                  40                  45              


Thr Leu Ala Cys Ala Arg Ala Ser Ala Leu Cys Leu Asn Phe Asn Ser 
    50                  55                  60                  


Thr Leu Ile Leu Leu Pro Val Cys Arg Asn Leu Leu Ser Phe Leu Arg 
65                  70                  75                  80  


Gly Thr Cys Ser Phe Cys Ser Arg Thr Leu Arg Lys Gln Leu Asp His 
                85                  90                  95      


Asn Leu Thr Phe His Lys Leu Val Ala Tyr Met Ile Cys Leu His Thr 
            100                 105                 110         


Ala Ile His Ile Ile Ala His Leu Phe Asn Phe Asp Cys Tyr Ser Arg 
        115                 120                 125             


Ser Arg Gln Ala Thr Asp Gly Ser Leu Ala Ser Ile Leu Ser Ser Leu 
    130                 135                 140                 


Ser His Asp Glu Lys Lys Gly Gly Ser Trp Leu Asn Pro Ile Gln Ser 
145                 150                 155                 160 


Arg Asn Thr Thr Val Glu Tyr Val Thr Phe Thr Ser Ile Ala Gly Leu 
                165                 170                 175     


Thr Gly Val Ile Met Thr Ile Ala Leu Ile Leu Met Val Thr Ser Ala 
            180                 185                 190         


Thr Glu Phe Ile Arg Arg Ser Tyr Phe Glu Val Phe Trp Tyr Thr His 
        195                 200                 205             


His Leu Phe Ile Phe Tyr Ile Leu Gly Leu Gly Ile His Gly Ile Gly 
    210                 215                 220                 


Gly Ile Val Arg Gly Gln Thr Glu Glu Ser Met Asn Glu Ser His Pro 
225                 230                 235                 240 


Arg Lys Cys Ala Glu Ser Phe Glu Met Trp Asp Asp Arg Asp Ser His 
                245                 250                 255     


Cys Arg Arg Pro Lys Phe Glu Gly His Pro Pro Glu Ser Trp Lys Trp 
            260                 265                 270         


Ile Leu Ala Pro Val Ile Leu Tyr Ile Cys Glu Arg Ile Leu Arg Phe 
        275                 280                 285             


Tyr Arg Ser Gln Gln Lys Val Val Ile Thr Lys Val Val Met His Pro 
    290                 295                 300                 


Ser Lys Val Leu Glu Leu Gln Met Asn Lys Arg Gly Phe Ser Met Glu 
305                 310                 315                 320 


Val Gly Gln Tyr Ile Phe Val Asn Cys Pro Ser Ile Ser Leu Leu Glu 
                325                 330                 335     


Trp His Pro Phe Thr Leu Thr Ser Ala Pro Glu Glu Asp Phe Phe Ser 
            340                 345                 350         


Ile His Ile Arg Ala Ala Gly Asp Trp Thr Glu Asn Leu Ile Arg Ala 
        355                 360                 365             


Phe Glu Gln Gln Tyr Ser Pro Ile Pro Arg Ile Glu Val Asp Gly Pro 
    370                 375                 380                 


Phe Gly Thr Ala Ser Glu Asp Val Phe Gln Tyr Glu Val Ala Val Leu 
385                 390                 395                 400 


Val Gly Ala Gly Ile Gly Val Thr Pro Phe Ala Ser Ile Leu Lys Ser 
                405                 410                 415     


Ile Trp Tyr Lys Phe Gln Cys Ala Asp His Asn Leu Lys Thr Lys Lys 
            420                 425                 430         


Ile Tyr Phe Tyr Trp Ile Cys Arg Glu Thr Gly Ala Phe Ser Trp Phe 
        435                 440                 445             


Asn Asn Leu Leu Thr Ser Leu Glu Gln Glu Met Glu Glu Leu Gly Lys 
    450                 455                 460                 


Val Gly Phe Leu Asn Tyr Arg Leu Phe Leu Thr Gly Trp Asp Ser Asn 
465                 470                 475                 480 


Ile Val Gly His Ala Ala Leu Asn Phe Asp Lys Ala Thr Asp Ile Val 
                485                 490                 495     


Thr Gly Leu Lys Gln Lys Thr Ser Phe Gly Arg Pro Met Trp Asp Asn 
            500                 505                 510         


Glu Phe Ser Thr Ile Ala Thr Ser His Pro Lys Ser Val Val Gly Val 
        515                 520                 525             


Phe Leu Cys Gly Pro Arg Thr Leu Ala Lys Ser Leu Arg Lys Cys Cys 
    530                 535                 540                 


His Arg Tyr Ser Ser Leu Asp Pro Arg Lys Val Gln Phe Tyr Phe Asn 
545                 550                 555                 560 


Lys Glu Asn Phe 
                


<210>  3624
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  3624

Met Leu Leu Glu Pro Gly Arg Gly Cys Cys Ala Leu Ala Ile Leu Leu 
1               5                   10                  15      


Ala Ile Val Asp Ile Gln Ser Gly Gly Cys Ile Asn Ile Thr Ser Ser 
            20                  25                  30          


Ala Ser Gln Glu Gly Thr Arg Leu Asn Leu Ile Cys Thr Val Trp His 
        35                  40                  45              


Lys Lys Glu Glu Ala Glu Gly Phe Val Val Phe Leu Cys Lys Asp Arg 
    50                  55                  60                  


Ser Gly Asp Cys Ser Pro Glu Thr Ser Leu Lys Gln Leu Arg Leu Lys 
65                  70                  75                  80  


Arg Asp Pro Gly Ile Asp Gly Val Gly Glu Ile Ser Ser Gln Leu Met 
                85                  90                  95      


Phe Thr Ile Ser Gln Val Thr Pro Leu His Ser Gly Thr Tyr Gln Cys 
            100                 105                 110         


Cys Ala Arg Ser Gln Lys Ser Gly Ile Arg Leu Gln Gly His Phe Phe 
        115                 120                 125             


Ser Ile Leu Phe Thr Glu Thr Gly Asn Tyr Thr Val Thr Gly Leu Lys 
    130                 135                 140                 


Gln Arg Gln His Leu Glu Phe Ser His Asn Glu Gly Thr Leu Ser Ser 
145                 150                 155                 160 


Gly Phe Leu Gln Glu Lys Val Trp Val Met Leu Val Thr Ser Leu Val 
                165                 170                 175     


Ala Leu Gln Ala Leu 
            180     


<210>  3625
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  3625

Met Arg Ala Pro Ile Pro Glu Pro Lys Pro Gly Asp Leu Ile Glu Ile 
1               5                   10                  15      


Phe Arg Pro Phe Tyr Arg His Trp Ala Ile Tyr Val Gly Asp Gly Tyr 
            20                  25                  30          


Val Val His Leu Ala Pro Pro Ser Glu Val Ala Gly Ala Gly Ala Ala 
        35                  40                  45              


Ser Val Met Ser Ala Leu Thr Asp Lys Ala Ile Val Lys Lys Glu Leu 
    50                  55                  60                  


Leu Tyr Asp Val Ala Gly Ser Asp Lys Tyr Gln Val Asn Asn Lys His 
65                  70                  75                  80  


Asp Asp Lys Tyr Ser Pro Leu Pro Cys Ser Lys Ile Ile Gln Arg Ala 
                85                  90                  95      


Glu Glu Leu Val Gly Gln Glu Val Leu Tyr Lys Leu Thr Ser Glu Asn 
            100                 105                 110         


Cys Glu His Phe Val Asn Glu Leu Arg Tyr Gly Val Ala Arg Ser Asp 
        115                 120                 125             


Gln Val Arg Asp Val Ile Ile Ala Ala Ser Val Ala Gly Met Gly Leu 
    130                 135                 140                 


Ala Ala Met Ser Leu Ile Gly Val Met Phe Ser Arg Asn Lys Arg Gln 
145                 150                 155                 160 


Lys Gln 
        


<210>  3626
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  3626

Met Lys Ala Gln Thr Ala Leu Ser Phe Phe Leu Ile Leu Ile Thr Ser 
1               5                   10                  15      


Leu Ser Gly Ser Gln Gly Ile Phe Pro Leu Ala Phe Phe Ile Tyr Val 
            20                  25                  30          


Pro Met Asn Glu Gln Ile Val Ile Gly Arg Leu Asp Glu Asp Ile Ile 
        35                  40                  45              


Leu Pro Ser Ser Phe Glu Arg Gly Ser Glu Val Val Ile His Trp Lys 
    50                  55                  60                  


Tyr Gln Asp Ser Tyr Lys Val His Ser Tyr Tyr Lys Gly Ser Asp His 
65                  70                  75                  80  


Leu Glu Ser Gln Asp Pro Arg Tyr Ala Asn Arg Thr Ser Leu Phe Tyr 
                85                  90                  95      


Asn Glu Ile Gln Asn Gly Asn Ala Ser Leu Phe Phe Arg Arg Val Ser 
            100                 105                 110         


Leu Leu Asp Glu Gly Ile Tyr Thr Cys Tyr Val Gly Thr Ala Ile Gln 
        115                 120                 125             


Val Ile Thr Asn Lys Val Val Leu Lys Val Gly Val Phe Leu Thr Pro 
    130                 135                 140                 


Val Met Lys Tyr Glu Lys Arg Asn Thr Asn Ser Phe Leu Ile Cys Ser 
145                 150                 155                 160 


Val Leu Ser Val Tyr Pro Arg Pro Ile Ile Thr Trp Lys Met Asp Asn 
                165                 170                 175     


Thr Pro Ile Ser Glu Asn Asn Met Glu Glu Thr Gly Ser Leu Asp Ser 
            180                 185                 190         


Phe Ser Ile Asn Ser Pro Leu Asn Ile Thr Gly Ser Asn Ser Ser Tyr 
        195                 200                 205             


Glu Cys Thr Ile Glu Asn Ser Leu Leu Lys Gln Thr Trp Thr Gly Arg 
    210                 215                 220                 


Trp Thr Met Lys Asp Gly Leu His Lys Met Gln Ser Glu His Val Ser 
225                 230                 235                 240 


Leu Ser Cys Gln Pro Val Asn Asp Tyr Phe Ser Pro Asn Gln Asp Phe 
                245                 250                 255     


Lys Val Thr Trp Ser Arg Met Lys Ser Gly Thr Phe Ser Val Leu Ala 
            260                 265                 270         


Tyr Tyr Leu Ser Ser Ser Gln Asn Thr Ile Ile Asn Glu Ser Arg Phe 
        275                 280                 285             


Ser Trp Asn Lys Glu Leu Ile Asn Gln Ser Asp Phe Ser Met Asn Leu 
    290                 295                 300                 


Met Asp Leu Asn Leu Ser Asp Ser Gly Glu Tyr Leu Cys Asn Ile Ser 
305                 310                 315                 320 


Ser Asp Glu Tyr Thr Leu Leu Thr Ile His Thr Val His Val Glu Pro 
                325                 330                 335     


Ser Gln Glu Thr Ala Ser His Asn Lys Gly Leu Trp Ile Leu Val Pro 
            340                 345                 350         


Ser Ala Ile Leu Ala Ala Phe Leu Leu Ile Trp Ser Val Lys Cys Cys 
        355                 360                 365             


Arg Ala Gln Leu Glu Ala Arg Arg Ser Arg His Pro Ala Asp Gly Ala 
    370                 375                 380                 


Gln Gln Glu Arg Cys Cys Val Pro Pro Gly Glu Arg Cys Pro Ser Ala 
385                 390                 395                 400 


Pro Asp Asn Gly Glu Glu Asn Val Pro Leu Ser Gly Lys Val 
                405                 410                 


<210>  3627
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  3627

Met Asn Tyr Thr Glu Ser Ser Pro Leu Arg Glu Ser Thr Ala Ile Gly 
1               5                   10                  15      


Phe Thr Pro Glu Leu Glu Ser Ile Ile Pro Val Pro Ser Asn Lys Thr 
            20                  25                  30          


Thr Cys Glu Asn Trp Arg Glu Ile His His Leu Val Phe His Val Ala 
        35                  40                  45              


Asn Ile Cys Phe Ala Val Gly Leu Val Ile Pro Thr Thr Leu His Leu 
    50                  55                  60                  


His Met Ile Phe Leu Arg Gly Met Leu Thr Leu Gly Cys Thr Leu Tyr 
65                  70                  75                  80  


Ile Val Trp Ala Thr Leu Tyr Arg Cys Ala Leu Asp Ile Met Ile Trp 
                85                  90                  95      


Asn Ser Val Phe Leu Gly Val Asn Ile Leu His Leu Ser Tyr Leu Leu 
            100                 105                 110         


Tyr Lys Lys Arg Pro Val Lys Ile Glu Lys Glu Leu Ser Gly Met Tyr 
        115                 120                 125             


Arg Arg Leu Phe Glu Pro Leu Arg Val Pro Pro Asp Leu Phe Arg Arg 
    130                 135                 140                 


Leu Thr Gly Gln Phe Cys Met Ile Gln Thr Leu Lys Lys Gly Gln Thr 
145                 150                 155                 160 


Tyr Ala Ala Glu Asp Lys Thr Ser Val Asp Asp Arg Leu Ser Ile Leu 
                165                 170                 175     


Leu Lys Gly Lys Met Lys Val Ser Tyr Arg Gly His Phe Leu His Asn 
            180                 185                 190         


Ile Tyr Pro Cys Ala Phe Ile Asp Ser Pro Glu Phe Arg Ser Thr Gln 
        195                 200                 205             


Met His Lys Gly Glu Lys Phe Gln Val Thr Ile Ile Ala Asp Asp Asn 
    210                 215                 220                 


Cys Arg Phe Leu Cys Trp Ser Arg Glu Arg Leu Thr Tyr Phe Leu Glu 
225                 230                 235                 240 


Ser Glu Pro Phe Leu Tyr Glu Ile Phe Arg Tyr Leu Ile Gly Lys Asp 
                245                 250                 255     


Ile Thr Asn Lys Leu Tyr Ser Leu Asn Asp Pro Thr Leu Asn Asp Lys 
            260                 265                 270         


Lys Ala Lys Lys Leu Glu His Gln Leu Ser Leu Cys Thr Gln Ile Ser 
        275                 280                 285             


Met Leu Glu Met Arg Asn Ser Ile Ala Ser Ser Ser Asp Ser Asp Asp 
    290                 295                 300                 


Gly Leu His Gln Phe Leu Arg Gly Thr Ser Ser Met Ser Ser Leu His 
305                 310                 315                 320 


Val Ser Ser Pro His Gln Arg Ala Ser Ala Lys Met Lys Pro Ile Glu 
                325                 330                 335     


Glu Gly Ala Glu Asp Asp Asp Asp Val Phe Glu Pro Ala Ser Pro Asn 
            340                 345                 350         


Thr Leu Lys Val His Gln Leu Pro 
        355                 360 


<210>  3628
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  3628

Met Met Leu Ile Pro Met Ala Ser Val Met Ala Val Thr Glu Pro Lys 
1               5                   10                  15      


Trp Val Ser Val Trp Ser Arg Phe Leu Trp Val Thr Leu Leu Ser Met 
            20                  25                  30          


Val Leu Gly Ser Leu Leu Ala Leu Leu Leu Pro Leu Gly Ala Val Glu 
        35                  40                  45              


Glu Gln Cys Leu Ala Val Leu Lys Gly Leu Tyr Leu Leu Arg Ser Lys 
    50                  55                  60                  


Pro Asp Arg Ala Gln His Ala Ala Thr Lys Cys Thr Ser Pro Ser Thr 
65                  70                  75                  80  


Glu Leu Ser Ile Thr Ser Arg Gly Ala Thr Leu Leu Val Ala Lys Thr 
                85                  90                  95      


Lys Ala Ser Pro Ala Gly Lys Leu Glu Ala Arg Ala Ala Leu Asn Gln 
            100                 105                 110         


Ala Leu Glu Met Lys Arg Gln Gly Lys Arg Glu Lys Ala Gln Lys Leu 
        115                 120                 125             


Phe Met His Ala Leu Lys Met Asp Pro Asp Phe Val Asp Ala Leu Thr 
    130                 135                 140                 


Glu Phe Gly Ile Phe Ser Glu Glu Asp Lys Asp Ile Ile Gln Ala Asp 
145                 150                 155                 160 


Tyr Leu Tyr Thr Arg Ala Leu Thr Ile Ser Pro Tyr His Glu Lys Ala 
                165                 170                 175     


Leu Val Asn Arg Asp Arg Thr Leu Pro Leu Val Glu Glu Ile Asp Gln 
            180                 185                 190         


Arg Tyr Phe Ser Ile Ile Asp Ser Lys Val Lys Lys Val Met Ser Ile 
        195                 200                 205             


Pro Lys Gly Asn Ser Ala Leu Arg Arg Val Met Glu Glu Thr Tyr Tyr 
    210                 215                 220                 


His His Ile Tyr His Thr Val Ala Ile Glu Gly Asn Thr Leu Thr Leu 
225                 230                 235                 240 


Ser Glu Ile Arg His Ile Leu Glu Thr Arg Tyr Ala Val Pro Gly Lys 
                245                 250                 255     


Ser Leu Glu Glu Gln Asn Glu Val Ile Gly Met His Ala Ala Met Lys 
            260                 265                 270         


Tyr Ile Asn Thr Thr Leu Val Ser Arg Ile Gly Ser Val Thr Ile Ser 
        275                 280                 285             


Asp Val Leu Glu Ile His Arg Arg Val Leu Gly Tyr Val Asp Pro Val 
    290                 295                 300                 


Glu Ala Gly Arg Phe Arg Thr Thr Gln Val Leu Val Gly His His Ile 
305                 310                 315                 320 


Pro Pro His Pro Gln Asp Val Glu Lys Gln Met Gln Glu Phe Val Gln 
                325                 330                 335     


Trp Leu Asn Ser Glu Glu Ala Met Asn Leu His Pro Val Glu Phe Ala 
            340                 345                 350         


Ala Leu Ala His Tyr Lys Leu Val Tyr Ile His Pro Phe Ile Asp Gly 
        355                 360                 365             


Asn Gly Arg Thr Ser Arg Leu Leu Met Asn Leu Ile Leu Met Gln Ala 
    370                 375                 380                 


Gly Tyr Pro Pro Ile Thr Ile Arg Lys Glu Gln Arg Ser Asp Tyr Tyr 
385                 390                 395                 400 


His Val Leu Glu Ala Ala Asn Glu Gly Asp Val Arg Pro Phe Ile Arg 
                405                 410                 415     


Phe Ile Ala Lys Cys Thr Glu Thr Thr Leu Asp Thr Leu Leu Phe Ala 
            420                 425                 430         


Thr Thr Glu Tyr Ser Val Ala Leu Pro Glu Ala Gln Pro Asn His Ser 
        435                 440                 445             


Gly Phe Lys Glu Thr Leu Pro Val Lys Pro 
    450                 455             


<210>  3629
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  3629

Met Ala Glu Gln Ala Thr Lys Ser Val Leu Phe Val Cys Leu Gly Asn 
1               5                   10                  15      


Ile Cys Arg Ser Pro Ile Ala Glu Ala Val Phe Arg Lys Leu Val Thr 
            20                  25                  30          


Asp Gln Asn Ile Ser Glu Asn Trp Val Ile Asp Ser Gly Ala Val Ser 
        35                  40                  45              


Asp Trp Asn Val Gly Arg Ser Pro Asp Pro Arg Ala Val Ser Cys Leu 
    50                  55                  60                  


Arg Asn His Gly Ile His Thr Ala His Lys Ala Arg Gln Ile Thr Lys 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Phe Asp Tyr Ile Leu Cys Met Asp Glu Ser Asn 
                85                  90                  95      


Leu Arg Asp Leu Asn Arg Lys Ser Asn Gln Val Lys Thr Cys Lys Ala 
            100                 105                 110         


Lys Ile Glu Leu Leu Gly Ser Tyr Asp Pro Gln Lys Gln Leu Ile Ile 
        115                 120                 125             


Glu Asp Pro Tyr Tyr Gly Asn Asp Ser Asp Phe Glu Thr Val Tyr Gln 
    130                 135                 140                 


Gln Cys Val Arg Cys Cys Arg Ala Phe Leu Glu Lys Ala His 
145                 150                 155             


<210>  3630
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  3630

Met Gly Cys Arg Ala Ala Ser Gly Leu Leu Pro Gly Val Ala Val Val 
1               5                   10                  15      


Leu Leu Leu Leu Leu Gln Ser Thr Gln Ser Val Tyr Ile Gln Tyr Gln 
            20                  25                  30          


Gly Phe Arg Val Gln Leu Glu Ser Met Lys Lys Leu Ser Asp Leu Glu 
        35                  40                  45              


Ala Gln Trp Ala Pro Ser Pro Arg Leu Gln Ala Gln Ser Leu Leu Pro 
    50                  55                  60                  


Ala Val Cys His His Pro Ala Leu Pro Gln Asp Leu Gln Pro Val Cys 
65                  70                  75                  80  


Ala Ser Gln Glu Ala Ser Ser Ile Phe Lys Thr Leu Arg Thr Ile Ala 
                85                  90                  95      


Asn Asp Asp Cys Glu Leu Cys Val Asn Val Ala Cys Thr Gly Cys Leu 
            100                 105                 110         


<210>  3631
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  3631

Met Ala Pro Lys Gly Ser Ser Lys Gln Gln Ser Glu Glu Asp Leu Leu 
1               5                   10                  15      


Leu Gln Asp Phe Ser Arg Asn Leu Ser Ala Lys Ser Ser Ala Leu Phe 
            20                  25                  30          


Phe Gly Asn Ala Phe Ile Val Ser Ala Ile Pro Ile Trp Leu Tyr Trp 
        35                  40                  45              


Arg Ile Trp His Met Asp Leu Ile Gln Ser Ala Val Leu Tyr Ser Val 
    50                  55                  60                  


Met Thr Leu Val Ser Thr Tyr Leu Val Ala Phe Ala Tyr Lys Asn Val 
65                  70                  75                  80  


Lys Phe Val Leu Lys His Lys Val Ala Gln Lys Arg Glu Asp Ala Val 
                85                  90                  95      


Ser Lys Glu Val Thr Arg Lys Leu Ser Glu Ala Asp Asn Arg Lys Met 
            100                 105                 110         


Ser Arg Lys Glu Lys Asp Glu Arg Ile Leu Trp Lys Lys Asn Glu Val 
        115                 120                 125             


Ala Asp Tyr Glu Ala Thr Thr Phe Ser Ile Phe Tyr Asn Asn Thr Leu 
    130                 135                 140                 


Phe Leu Val Val Val Ile Val Ala Ser Phe Phe Ile Leu Lys Asn Phe 
145                 150                 155                 160 


Asn Pro Thr Val Asn Tyr Ile Leu Ser Ile Ser Ala Ser Ser Gly Leu 
                165                 170                 175     


Ile Ala Leu Leu Ser Thr Gly Ser Lys 
            180                 185 


<210>  3632
<211>  534
<212>  PRT
<213>  Homo sapiens

<400>  3632

Met Ala Arg Gly Leu Gln Val Pro Leu Pro Arg Leu Ala Thr Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Val Gln Pro Trp Ala Glu Ser Gly Lys Val Leu 
            20                  25                  30          


Val Val Pro Thr Asp Gly Ser Pro Trp Leu Ser Met Arg Glu Ala Leu 
        35                  40                  45              


Arg Glu Leu His Ala Arg Gly His Gln Ala Val Val Leu Thr Pro Glu 
    50                  55                  60                  


Val Asn Met His Ile Lys Glu Glu Lys Phe Phe Thr Leu Thr Ala Tyr 
65                  70                  75                  80  


Ala Val Pro Trp Thr Gln Lys Glu Phe Asp Arg Val Thr Leu Gly Tyr 
                85                  90                  95      


Thr Gln Gly Phe Phe Glu Thr Glu His Leu Leu Lys Arg Tyr Ser Arg 
            100                 105                 110         


Ser Met Ala Ile Met Asn Asn Val Ser Leu Ala Leu His Arg Cys Cys 
        115                 120                 125             


Val Glu Leu Leu His Asn Glu Ala Leu Ile Arg His Leu Asn Ala Thr 
    130                 135                 140                 


Ser Phe Asp Val Val Leu Thr Asp Pro Val Asn Leu Cys Gly Ala Val 
145                 150                 155                 160 


Leu Ala Lys Tyr Leu Ser Ile Pro Ala Val Phe Phe Trp Arg Tyr Ile 
                165                 170                 175     


Pro Cys Asp Leu Asp Phe Lys Gly Thr Gln Cys Pro Asn Pro Ser Ser 
            180                 185                 190         


Tyr Ile Pro Lys Leu Leu Thr Thr Asn Ser Asp His Met Thr Phe Leu 
        195                 200                 205             


Gln Arg Val Lys Asn Met Leu Tyr Pro Leu Ala Leu Ser Tyr Ile Cys 
    210                 215                 220                 


His Thr Phe Ser Ala Pro Tyr Ala Ser Leu Ala Ser Glu Leu Phe Gln 
225                 230                 235                 240 


Arg Glu Val Ser Val Val Asp Leu Val Ser Tyr Ala Ser Val Trp Leu 
                245                 250                 255     


Phe Arg Gly Asp Phe Val Met Asp Tyr Pro Arg Pro Ile Met Pro Asn 
            260                 265                 270         


Met Val Phe Ile Gly Gly Ile Asn Cys Ala Asn Gly Lys Pro Leu Ser 
        275                 280                 285             


Gln Glu Phe Glu Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val 
    290                 295                 300                 


Val Phe Ser Leu Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala 
305                 310                 315                 320 


Met Ala Ile Ala Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp 
                325                 330                 335     


Arg Tyr Thr Gly Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu 
            340                 345                 350         


Val Lys Trp Leu Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg 
        355                 360                 365             


Ala Phe Ile Thr His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys 
    370                 375                 380                 


Asn Gly Val Pro Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp 
385                 390                 395                 400 


Asn Ala Lys Arg Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val 
                405                 410                 415     


Leu Glu Met Thr Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile 
            420                 425                 430         


Asn Asp Lys Ser Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His 
        435                 440                 445             


Lys Asp Arg Pro Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu 
    450                 455                 460                 


Phe Val Met Arg His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His 
465                 470                 475                 480 


Asp Leu Thr Trp Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu 
                485                 490                 495     


Leu Ala Val Val Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala 
            500                 505                 510         


Tyr Gly Tyr Arg Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala 
        515                 520                 525             


His Lys Ser Lys Thr His 
    530                 


<210>  3633
<211>  1347
<212>  PRT
<213>  Homo sapiens

<400>  3633

Met Lys Ser Cys Ala Val Ser Leu Thr Thr Ala Ala Val Ala Phe Gly 
1               5                   10                  15      


Asp Glu Ala Lys Lys Met Ala Glu Gly Lys Ala Ser Arg Glu Ser Glu 
            20                  25                  30          


Glu Glu Ser Val Ser Leu Thr Val Glu Glu Arg Glu Ala Leu Gly Gly 
        35                  40                  45              


Met Asp Ser Arg Leu Phe Gly Phe Val Arg Leu His Glu Asp Gly Ala 
    50                  55                  60                  


Arg Thr Lys Thr Leu Leu Gly Lys Ala Val Arg Cys Tyr Glu Ser Leu 
65                  70                  75                  80  


Ile Leu Lys Ala Glu Gly Lys Val Glu Ser Asp Phe Phe Cys Gln Leu 
                85                  90                  95      


Gly His Phe Asn Leu Leu Leu Glu Asp Tyr Ser Lys Ala Leu Ser Ala 
            100                 105                 110         


Tyr Gln Arg Tyr Tyr Ser Leu Gln Ala Asp Tyr Trp Lys Asn Ala Ala 
        115                 120                 125             


Phe Leu Tyr Gly Leu Gly Leu Val Tyr Phe Tyr Tyr Asn Ala Phe His 
    130                 135                 140                 


Trp Ala Ile Lys Ala Phe Gln Asp Val Leu Tyr Val Asp Pro Ser Phe 
145                 150                 155                 160 


Cys Arg Ala Lys Glu Ile His Leu Arg Leu Gly Leu Met Phe Lys Val 
                165                 170                 175     


Asn Thr Asp Tyr Lys Ser Ser Leu Lys His Phe Gln Leu Ala Leu Ile 
            180                 185                 190         


Asp Cys Asn Pro Cys Thr Leu Ser Asn Ala Glu Ile Gln Phe His Ile 
        195                 200                 205             


Ala His Leu Tyr Glu Thr Gln Arg Lys Tyr His Ser Ala Lys Glu Ala 
    210                 215                 220                 


Tyr Glu Gln Leu Leu Gln Thr Glu Asn Leu Pro Ala Gln Val Lys Ala 
225                 230                 235                 240 


Thr Val Leu Gln Gln Leu Gly Trp Met His His Asn Met Asp Leu Val 
                245                 250                 255     


Gly Asp Lys Ala Thr Lys Glu Ser Tyr Ala Ile Gln Tyr Leu Gln Lys 
            260                 265                 270         


Ser Leu Glu Ala Asp Pro Asn Ser Gly Gln Ser Trp Tyr Phe Leu Gly 
        275                 280                 285             


Arg Cys Tyr Ser Ser Ile Gly Lys Val Gln Asp Ala Phe Ile Ser Tyr 
    290                 295                 300                 


Arg Gln Ser Ile Asp Lys Ser Glu Ala Ser Ala Asp Thr Trp Cys Ser 
305                 310                 315                 320 


Ile Gly Val Leu Tyr Gln Gln Gln Asn Gln Pro Met Asp Ala Leu Gln 
                325                 330                 335     


Ala Tyr Ile Cys Ala Val Gln Leu Asp His Gly His Ala Ala Ala Trp 
            340                 345                 350         


Met Asp Leu Gly Thr Leu Tyr Glu Ser Cys Asn Gln Pro Gln Asp Ala 
        355                 360                 365             


Ile Lys Cys Tyr Leu Asn Ala Ala Arg Ser Lys Arg Cys Ser Asn Thr 
    370                 375                 380                 


Ser Thr Leu Ala Ala Arg Ile Lys Phe Leu Gln Asn Gly Ser Asp Asn 
385                 390                 395                 400 


Trp Asn Gly Gly Gln Ser Leu Ser His His Pro Val Gln Gln Val Tyr 
                405                 410                 415     


Ser Leu Cys Leu Thr Pro Gln Lys Leu Gln His Leu Glu Gln Leu Arg 
            420                 425                 430         


Ala Asn Arg Asp Asn Leu Asn Pro Ala Gln Lys His Gln Leu Glu Gln 
        435                 440                 445             


Leu Glu Ser Gln Phe Val Leu Met Gln Gln Met Arg His Lys Glu Val 
    450                 455                 460                 


Ala Gln Val Arg Thr Thr Gly Ile His Asn Gly Ala Ile Thr Asp Ser 
465                 470                 475                 480 


Ser Leu Pro Thr Asn Ser Val Ser Asn Arg Gln Pro His Gly Ala Leu 
                485                 490                 495     


Thr Arg Val Ser Ser Val Ser Gln Pro Gly Val Arg Pro Ala Cys Val 
            500                 505                 510         


Glu Lys Leu Leu Ser Ser Gly Ala Phe Ser Ala Gly Cys Ile Pro Cys 
        515                 520                 525             


Gly Thr Ser Lys Ile Leu Gly Ser Thr Asp Thr Ile Leu Leu Gly Ser 
    530                 535                 540                 


Asn Cys Ile Ala Gly Ser Glu Ser Asn Gly Asn Val Pro Tyr Leu Gln 
545                 550                 555                 560 


Gln Asn Thr His Thr Leu Pro His Asn His Thr Asp Leu Asn Ser Ser 
                565                 570                 575     


Thr Glu Glu Pro Trp Arg Lys Gln Leu Ser Asn Ser Ala Gln Gly Leu 
            580                 585                 590         


His Lys Ser Gln Ser Ser Cys Leu Ser Gly Pro Asn Glu Glu Gln Pro 
        595                 600                 605             


Leu Phe Ser Thr Gly Ser Ala Gln Tyr His Gln Ala Thr Ser Thr Gly 
    610                 615                 620                 


Ile Lys Lys Ala Asn Glu His Leu Thr Leu Pro Ser Asn Ser Val Pro 
625                 630                 635                 640 


Gln Gly Asp Ala Asp Ser His Leu Ser Cys His Thr Ala Thr Ser Gly 
                645                 650                 655     


Gly Gln Gln Gly Ile Met Phe Thr Lys Glu Ser Lys Pro Ser Lys Asn 
            660                 665                 670         


Arg Ser Leu Val Pro Glu Thr Ser Arg His Thr Gly Asp Thr Ser Asn 
        675                 680                 685             


Gly Cys Ala Asp Val Lys Gly Leu Ser Asn His Val His Gln Leu Ile 
    690                 695                 700                 


Ala Asp Ala Val Ser Ser Pro Asn His Gly Asp Ser Pro Asn Leu Leu 
705                 710                 715                 720 


Ile Ala Asp Asn Pro Gln Leu Ser Ala Leu Leu Ile Gly Lys Ala Asn 
                725                 730                 735     


Gly Asn Val Gly Thr Gly Thr Cys Asp Lys Val Asn Asn Ile His Pro 
            740                 745                 750         


Ala Val His Thr Lys Thr Asp His Ser Val Ala Ser Ser Pro Ser Ser 
        755                 760                 765             


Ala Ile Ser Thr Ala Thr Pro Ser Pro Lys Ser Thr Glu Gln Arg Ser 
    770                 775                 780                 


Ile Asn Ser Val Thr Ser Leu Asn Ser Pro His Ser Gly Leu His Thr 
785                 790                 795                 800 


Val Asn Gly Glu Gly Leu Gly Lys Ser Gln Ser Ser Thr Lys Val Asp 
                805                 810                 815     


Leu Pro Leu Ala Ser His Arg Ser Thr Ser Gln Ile Leu Pro Ser Met 
            820                 825                 830         


Ser Val Ser Ile Cys Pro Ser Ser Thr Glu Val Leu Lys Ala Cys Arg 
        835                 840                 845             


Asn Pro Gly Lys Asn Gly Leu Ser Asn Ser Cys Ile Leu Leu Asp Lys 
    850                 855                 860                 


Cys Pro Pro Pro Arg Pro Pro Thr Ser Pro Tyr Pro Pro Leu Pro Lys 
865                 870                 875                 880 


Asp Lys Leu Asn Pro Pro Thr Pro Ser Ile Tyr Leu Glu Asn Lys Arg 
                885                 890                 895     


Asp Ala Phe Phe Pro Pro Leu His Gln Phe Cys Thr Asn Pro Lys Asn 
            900                 905                 910         


Pro Val Thr Val Ile Arg Gly Leu Ala Gly Ala Leu Lys Leu Asp Leu 
        915                 920                 925             


Gly Leu Phe Ser Thr Lys Thr Leu Val Glu Ala Asn Asn Glu His Met 
    930                 935                 940                 


Val Glu Val Arg Thr Gln Leu Leu Gln Pro Ala Asp Glu Asn Trp Asp 
945                 950                 955                 960 


Pro Thr Gly Thr Lys Lys Ile Trp Arg Cys Glu Ser Asn Arg Ser His 
                965                 970                 975     


Thr Thr Ile Ala Lys Tyr Ala Gln Tyr Gln Ala Ser Ser Phe Gln Glu 
            980                 985                 990         


Ser Leu Arg Glu Glu Asn Glu Lys  Arg Thr Gln His Lys  Asp His Ser 
        995                 1000                 1005             


Asp Asn  Glu Ser Thr Ser Ser  Glu Asn Ser Gly Arg  Arg Arg Lys 
    1010                 1015                 1020             


Gly Pro  Phe Lys Thr Ile Lys  Phe Gly Thr Asn Ile  Asp Leu Ser 
    1025                 1030                 1035             


Asp Asn  Lys Lys Trp Lys Leu  Gln Leu His Glu Leu  Thr Lys Leu 
    1040                 1045                 1050             


Pro Ala  Phe Ala Arg Val Val  Ser Ala Gly Asn Leu  Leu Thr His 
    1055                 1060                 1065             


Val Gly  His Thr Ile Leu Gly  Met Asn Thr Val Gln  Leu Tyr Met 
    1070                 1075                 1080             


Lys Val  Pro Gly Ser Arg Thr  Pro Gly His Gln Glu  Asn Asn Asn 
    1085                 1090                 1095             


Phe Cys  Ser Val Asn Ile Asn  Ile Gly Pro Gly Asp  Cys Glu Trp 
    1100                 1105                 1110             


Phe Val  Val Pro Glu Asp Tyr  Trp Gly Val Leu Asn  Asp Phe Cys 
    1115                 1120                 1125             


Glu Lys  Asn Asn Leu Asn Phe  Leu Met Ser Ser Trp  Trp Pro Asn 
    1130                 1135                 1140             


Leu Glu  Asp Leu Tyr Glu Ala  Asn Val Pro Val Tyr  Arg Phe Ile 
    1145                 1150                 1155             


Gln Arg  Pro Gly Asp Leu Val  Trp Ile Asn Ala Gly  Thr Val His 
    1160                 1165                 1170             


Trp Val  Gln Ala Val Gly Trp  Cys Asn Asn Ile Ala  Trp Asn Val 
    1175                 1180                 1185             


Gly Pro  Leu Thr Ala Cys Gln  Tyr Lys Leu Ala Val  Glu Arg Tyr 
    1190                 1195                 1200             


Glu Trp  Asn Lys Leu Lys Ser  Val Lys Ser Pro Val  Pro Met Val 
    1205                 1210                 1215             


His Leu  Ser Trp Asn Met Ala  Arg Asn Ile Lys Val  Ser Asp Pro 
    1220                 1225                 1230             


Lys Leu  Phe Glu Met Ile Lys  Tyr Cys Leu Leu Lys  Ile Leu Lys 
    1235                 1240                 1245             


Gln Tyr  Gln Thr Leu Arg Glu  Ala Leu Val Ala Ala  Gly Lys Glu 
    1250                 1255                 1260             


Val Ile  Trp His Gly Arg Thr  Asn Asp Glu Pro Ala  His Tyr Cys 
    1265                 1270                 1275             


Ser Ile  Cys Glu Val Glu Val  Phe Asn Leu Leu Phe  Val Thr Asn 
    1280                 1285                 1290             


Glu Ser  Asn Thr Gln Lys Thr  Tyr Ile Val His Cys  His Asp Cys 
    1295                 1300                 1305             


Ala Arg  Lys Thr Ser Lys Ser  Leu Glu Asn Phe Val  Val Leu Glu 
    1310                 1315                 1320             


Gln Tyr  Lys Met Glu Asp Leu  Ile Gln Val Tyr Asp  Gln Phe Thr 
    1325                 1330                 1335             


Leu Ala  Leu Ser Leu Ser Ser  Ser Ser 
    1340                 1345         


<210>  3634
<211>  631
<212>  PRT
<213>  Homo sapiens

<400>  3634

Met Pro Arg Pro Ala Leu Ser Val Thr Ser Phe Cys His Arg Leu Gly 
1               5                   10                  15      


Lys Arg Glu Arg Lys Gln Ser Phe Met Gly Asn Ser Gly Asn Ser Trp 
            20                  25                  30          


Ser His Thr Pro Phe Pro Lys Leu Glu Leu Gly Leu Gly Pro Gln Pro 
        35                  40                  45              


Met Ala Pro Arg Glu Leu Pro Thr Cys Ser Ile Cys Leu Glu Arg Leu 
    50                  55                  60                  


Arg Asp Pro Ile Ser Leu Asp Cys Gly His Asp Phe Cys Ile Arg Cys 
65                  70                  75                  80  


Phe Ser Thr His Arg Leu Pro Gly Cys Glu Pro Pro Cys Cys Pro Glu 
                85                  90                  95      


Cys Arg Lys Ile Cys Lys Gln Lys Arg Gly Leu Arg Ser Leu Gly Glu 
            100                 105                 110         


Lys Met Lys Leu Leu Pro Gln Arg Pro Leu Pro Pro Ala Leu Gln Glu 
        115                 120                 125             


Thr Cys Pro Val Arg Ala Glu Pro Leu Leu Leu Val Arg Ile Asn Ala 
    130                 135                 140                 


Ser Gly Gly Leu Ile Leu Arg Met Gly Ala Ile Asn Arg Cys Leu Lys 
145                 150                 155                 160 


His Pro Leu Ala Arg Asp Thr Pro Val Cys Leu Leu Ala Val Leu Gly 
                165                 170                 175     


Glu Gln His Ser Gly Lys Ser Phe Leu Leu Asn His Leu Leu Gln Gly 
            180                 185                 190         


Leu Pro Gly Leu Glu Ser Gly Glu Gly Gly Arg Pro Arg Gly Gly Glu 
        195                 200                 205             


Ala Ser Leu Gln Gly Cys Arg Trp Gly Ala Asn Gly Leu Ala Arg Gly 
    210                 215                 220                 


Ile Trp Met Trp Ser His Pro Phe Leu Leu Gly Lys Glu Gly Lys Lys 
225                 230                 235                 240 


Val Ala Val Phe Leu Val Asp Thr Gly Asp Ala Met Ser Pro Glu Leu 
                245                 250                 255     


Ser Arg Glu Thr Arg Ile Lys Leu Cys Ala Leu Thr Thr Met Leu Ser 
            260                 265                 270         


Ser Tyr Gln Ile Leu Ser Thr Ser Gln Glu Leu Lys Asp Thr Asp Leu 
        275                 280                 285             


Asp Tyr Leu Glu Met Phe Val His Val Ala Glu Val Met Gly Lys His 
    290                 295                 300                 


Tyr Gly Met Val Pro Ile Gln His Leu Asp Leu Leu Val Arg Asp Ser 
305                 310                 315                 320 


Ser His Pro Asn Lys Ala Gly Gln Gly His Val Gly Asn Ile Phe Gln 
                325                 330                 335     


Arg Leu Ser Gly Arg Tyr Pro Lys Val Gln Glu Leu Leu Gln Gly Lys 
            340                 345                 350         


Arg Ala Arg Cys Cys Leu Leu Pro Ala Pro Gly Arg Arg Arg Met Asn 
        355                 360                 365             


Gln Gly His Ala Ser Pro Gly Asp Thr Asp Asp Asp Phe Arg His Leu 
    370                 375                 380                 


Leu Gly Ala Tyr Val Ser Asp Val Leu Ser Ala Ala Pro Gln His Ala 
385                 390                 395                 400 


Lys Ser Arg Cys Gln Gly Tyr Trp Asn Glu Gly Arg Ala Val Ala Arg 
                405                 410                 415     


Gly Asp Arg Arg Leu Leu Thr Gly Gln Gln Leu Ala Gln Glu Ile Lys 
            420                 425                 430         


Asn Leu Ser Gly Trp Met Gly Arg Thr Gly Pro Gly Phe Thr Ser Pro 
        435                 440                 445             


Asp Glu Met Ala Ala Gln Leu His Asp Leu Arg Lys Val Glu Ala Ala 
    450                 455                 460                 


Lys Arg Glu Phe Glu Glu Tyr Val Arg Gln Gln Asp Val Ala Thr Lys 
465                 470                 475                 480 


Arg Ile Phe Ser Ala Leu Arg Val Leu Pro Asp Thr Met Arg Asn Leu 
                485                 490                 495     


Leu Ser Thr Gln Lys Asp Ala Ile Leu Ala Arg His Gly Val Ala Leu 
            500                 505                 510         


Leu Cys Lys Gly Arg Asp Gln Thr Leu Glu Ala Leu Glu Ala Glu Leu 
        515                 520                 525             


Gln Ala Thr Ala Lys Ala Phe Met Asp Ser Tyr Thr Met Arg Phe Cys 
    530                 535                 540                 


Gly His Leu Ala Ala Val Gly Gly Ala Val Gly Ala Gly Leu Met Gly 
545                 550                 555                 560 


Leu Ala Gly Gly Val Val Gly Ala Gly Met Ala Ala Ala Ala Leu Ala 
                565                 570                 575     


Ala Glu Ala Gly Met Val Ala Ala Gly Ala Ala Val Gly Ala Thr Gly 
            580                 585                 590         


Ala Ala Val Val Gly Gly Gly Val Gly Ala Gly Leu Ala Ala Thr Val 
        595                 600                 605             


Gly Cys Met Glu Lys Glu Glu Asp Glu Arg Leu Leu Glu Gly Asp Arg 
    610                 615                 620                 


Glu Pro Leu Leu Gln Glu Glu 
625                 630     


<210>  3635
<211>  811
<212>  PRT
<213>  Homo sapiens

<400>  3635

Met Pro Ser Ala Leu Ala Ile Phe Thr Cys Arg Pro Asn Ser His Pro 
1               5                   10                  15      


Phe Gln Glu Arg His Val Tyr Leu Asp Glu Pro Ile Lys Ile Gly Arg 
            20                  25                  30          


Ser Val Ala Arg Cys Arg Pro Ala Gln Asn Asn Ala Thr Phe Asp Cys 
        35                  40                  45              


Lys Val Leu Ser Arg Asn His Ala Leu Val Trp Phe Asp His Lys Thr 
    50                  55                  60                  


Gly Lys Phe Tyr Leu Gln Asp Thr Lys Ser Ser Asn Gly Thr Phe Ile 
65                  70                  75                  80  


Asn Ser Gln Arg Leu Ser Arg Gly Ser Glu Glu Ser Pro Pro Cys Glu 
                85                  90                  95      


Ile Leu Ser Gly Asp Ile Ile Gln Phe Gly Val Asp Val Thr Glu Asn 
            100                 105                 110         


Thr Arg Lys Val Thr His Gly Cys Ile Val Ser Thr Ile Lys Leu Phe 
        115                 120                 125             


Leu Pro Asp Gly Met Glu Ala Arg Leu Arg Ser Asp Val Ile His Ala 
    130                 135                 140                 


Pro Leu Pro Ser Pro Val Asp Lys Val Ala Ala Asn Thr Pro Ser Met 
145                 150                 155                 160 


Tyr Ser Gln Glu Leu Phe Gln Leu Ser Gln Tyr Leu Gln Glu Ala Leu 
                165                 170                 175     


His Arg Glu Gln Met Leu Glu Gln Lys Leu Ala Thr Leu Gln Arg Leu 
            180                 185                 190         


Leu Ala Ile Thr Gln Glu Ala Ser Asp Thr Ser Trp Gln Ala Leu Ile 
        195                 200                 205             


Asp Glu Asp Arg Leu Leu Ser Arg Leu Glu Val Met Gly Asn Gln Leu 
    210                 215                 220                 


Gln Ala Cys Ser Lys Asn Gln Thr Glu Asp Ser Leu Arg Lys Glu Leu 
225                 230                 235                 240 


Ile Ala Leu Gln Glu Asp Lys His Asn Tyr Glu Thr Thr Ala Lys Glu 
                245                 250                 255     


Ser Leu Arg Arg Val Leu Gln Glu Lys Ile Glu Val Val Arg Lys Leu 
            260                 265                 270         


Ser Glu Val Glu Arg Ser Leu Ser Asn Thr Glu Asp Glu Cys Thr His 
        275                 280                 285             


Leu Lys Glu Met Asn Glu Arg Thr Gln Glu Glu Leu Arg Glu Leu Ala 
    290                 295                 300                 


Asn Lys Tyr Asn Gly Ala Val Asn Glu Ile Lys Asp Leu Ser Asp Lys 
305                 310                 315                 320 


Leu Lys Val Ala Glu Gly Lys Gln Glu Glu Ile Gln Gln Lys Gly Gln 
                325                 330                 335     


Ala Glu Lys Lys Glu Leu Gln His Lys Ile Asp Glu Met Glu Glu Lys 
            340                 345                 350         


Glu Gln Glu Leu Gln Ala Lys Ile Glu Ala Leu Gln Ala Asp Asn Asp 
        355                 360                 365             


Phe Thr Asn Glu Arg Leu Thr Ala Leu Gln Glu His Leu Leu Ser Lys 
    370                 375                 380                 


Ser Gly Gly Asp Cys Thr Phe Ile His Gln Phe Ile Glu Cys Gln Lys 
385                 390                 395                 400 


Lys Leu Ile Val Glu Gly His Leu Thr Lys Ala Val Glu Glu Thr Lys 
                405                 410                 415     


Leu Ser Lys Glu Asn Gln Thr Arg Ala Lys Glu Ser Asp Phe Ser Asp 
            420                 425                 430         


Thr Leu Ser Pro Ser Lys Glu Lys Ser Ser Asp Asp Thr Thr Asp Ala 
        435                 440                 445             


Gln Met Asp Glu Gln Asp Leu Asn Glu Pro Leu Ala Lys Val Ser Leu 
    450                 455                 460                 


Leu Lys Asp Asp Leu Gln Gly Ala Gln Ser Glu Ile Glu Ala Lys Gln 
465                 470                 475                 480 


Glu Ile Gln His Leu Arg Lys Glu Leu Ile Glu Ala Gln Glu Leu Ala 
                485                 490                 495     


Arg Thr Ser Lys Gln Lys Cys Phe Glu Leu Gln Ala Leu Leu Glu Glu 
            500                 505                 510         


Glu Arg Lys Ala Tyr Arg Asn Gln Val Glu Glu Ser Thr Lys Gln Ile 
        515                 520                 525             


Gln Val Leu Gln Ala Gln Leu Gln Arg Leu His Ile Asp Thr Glu Asn 
    530                 535                 540                 


Leu Arg Glu Glu Lys Asp Ser Glu Ile Thr Ser Thr Arg Asp Glu Leu 
545                 550                 555                 560 


Leu Ser Ala Arg Asp Glu Ile Leu Leu Leu His Gln Ala Ala Ala Lys 
                565                 570                 575     


Val Ala Ser Glu Arg Asp Thr Asp Ile Ala Ser Leu Gln Glu Glu Leu 
            580                 585                 590         


Lys Lys Val Arg Ala Glu Leu Glu Arg Trp Arg Lys Ala Ala Ser Glu 
        595                 600                 605             


Tyr Glu Lys Glu Ile Thr Ser Leu Gln Asn Ser Phe Gln Leu Arg Cys 
    610                 615                 620                 


Gln Gln Cys Glu Asp Gln Gln Arg Glu Glu Ala Thr Arg Leu Gln Gly 
625                 630                 635                 640 


Glu Leu Glu Lys Leu Arg Lys Glu Trp Asn Ala Leu Glu Thr Glu Cys 
                645                 650                 655     


His Ser Leu Lys Arg Glu Asn Val Leu Leu Ser Ser Glu Leu Gln Arg 
            660                 665                 670         


Gln Glu Lys Glu Leu His Asn Ser Gln Lys Gln Ser Leu Glu Leu Thr 
        675                 680                 685             


Ser Asp Leu Ser Ile Leu Gln Met Ser Arg Lys Glu Leu Glu Asn Gln 
    690                 695                 700                 


Val Gly Ser Leu Lys Glu Gln His Leu Arg Asp Ser Ala Asp Leu Lys 
705                 710                 715                 720 


Thr Leu Leu Ser Lys Ala Glu Asn Gln Ala Lys Asp Val Gln Lys Glu 
                725                 730                 735     


Tyr Glu Lys Thr Gln Thr Val Leu Ser Glu Leu Lys Leu Lys Phe Glu 
            740                 745                 750         


Met Thr Glu Gln Glu Lys Gln Ser Ile Thr Asp Glu Leu Lys Gln Cys 
        755                 760                 765             


Lys Asn Asn Leu Lys Leu Leu Arg Glu Lys Gly Asn Asn Lys Pro Trp 
    770                 775                 780                 


Pro Trp Met Pro Met Leu Ala Ala Leu Val Ala Val Thr Ala Ile Val 
785                 790                 795                 800 


Leu Tyr Val Pro Gly Leu Ala Arg Ala Ser Pro 
                805                 810     


<210>  3636
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  3636

Met Val Asn Gln Ser Ser Thr Pro Gly Phe Leu Leu Leu Gly Phe Ser 
1               5                   10                  15      


Glu His Pro Gly Leu Glu Arg Thr Leu Phe Val Val Val Leu Thr Ser 
            20                  25                  30          


Tyr Leu Leu Thr Leu Val Gly Asn Thr Leu Ile Ile Leu Leu Ser Ala 
        35                  40                  45              


Leu Asp Pro Lys Leu His Ser Pro Met Tyr Phe Phe Leu Ser Asn Leu 
    50                  55                  60                  


Ser Phe Leu Asp Leu Cys Phe Thr Thr Ser Cys Val Pro Gln Met Leu 
65                  70                  75                  80  


Val Asn Leu Trp Gly Pro Lys Lys Thr Ile Ser Phe Leu Asp Cys Ser 
                85                  90                  95      


Val Gln Ile Phe Ile Phe Leu Ser Leu Gly Thr Thr Glu Cys Ile Leu 
            100                 105                 110         


Leu Thr Val Met Ala Phe Asp Arg Tyr Val Ala Val Cys Gln Pro Leu 
        115                 120                 125             


His Tyr Ala Thr Ile Ile His Pro Arg Leu Cys Trp Gln Leu Ala Ser 
    130                 135                 140                 


Val Ala Trp Val Ile Gly Leu Val Glu Ser Val Val Gln Thr Pro Ser 
145                 150                 155                 160 


Thr Leu His Leu Pro Phe Cys Pro Asp Arg Gln Val Asp Asp Phe Val 
                165                 170                 175     


Cys Glu Val Pro Ala Leu Ile Arg Leu Ser Cys Glu Asp Thr Ser Tyr 
            180                 185                 190         


Asn Glu Ile Gln Val Ala Val Ala Ser Val Phe Ile Leu Val Val Pro 
        195                 200                 205             


Leu Ser Leu Ile Leu Val Ser Tyr Gly Ala Ile Thr Trp Ala Val Leu 
    210                 215                 220                 


Arg Ile Asn Ser Ala Lys Gly Arg Arg Lys Ala Phe Gly Thr Cys Ser 
225                 230                 235                 240 


Ser His Leu Thr Val Val Thr Leu Phe Tyr Ser Ser Val Ile Ala Val 
                245                 250                 255     


Tyr Leu Gln Pro Lys Asn Pro Tyr Ala Gln Glu Arg Gly Lys Phe Phe 
            260                 265                 270         


Gly Leu Phe Tyr Ala Val Gly Thr Pro Ser Leu Asn Pro Leu Ile Tyr 
        275                 280                 285             


Thr Leu Arg Asn Lys Glu Val Thr Arg Ala Phe Arg Arg Leu Leu Gly 
    290                 295                 300                 


Lys Glu Met Gly Leu Thr Gln Ser 
305                 310         


<210>  3637
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  3637

Met Leu Ser Arg Asn Asp Asp Ile Cys Ile Tyr Gly Gly Leu Gly Leu 
1               5                   10                  15      


Gly Gly Leu Leu Leu Leu Ala Val Val Leu Leu Ser Ala Cys Leu Cys 
            20                  25                  30          


Trp Leu His Arg Arg Val Lys Arg Leu Glu Arg Ser Trp His Leu Leu 
        35                  40                  45              


Ser Trp Ser Gln Ala Gln Gly Ser Ser Glu Gln Glu Leu His Tyr Ala 
    50                  55                  60                  


Ser Leu Gln Arg Leu Pro Val Pro Ser Ser Glu Gly Pro Asp Leu Arg 
65                  70                  75                  80  


Gly Arg Asp Lys Arg Gly Thr Lys Glu Asp Pro Arg Ala Asp Tyr Ala 
                85                  90                  95      


Cys Ile Ala Glu Asn Lys Pro Thr 
            100                 


<210>  3638
<211>  920
<212>  PRT
<213>  Homo sapiens

<400>  3638

Met Ser Asp Pro His Ser Ser Pro Leu Leu Pro Glu Pro Leu Ser Ser 
1               5                   10                  15      


Arg Tyr Lys Leu Tyr Glu Ala Glu Phe Thr Ser Pro Ser Trp Pro Ser 
            20                  25                  30          


Thr Ser Pro Asp Thr His Pro Ala Leu Pro Leu Leu Glu Met Pro Glu 
        35                  40                  45              


Glu Lys Asp Leu Arg Ser Ser Asn Glu Asp Ser His Ile Val Lys Ile 
    50                  55                  60                  


Glu Lys Leu Asn Glu Arg Ser Lys Arg Lys Asp Asp Gly Val Ala His 
65                  70                  75                  80  


Arg Asp Ser Ala Gly Gln Arg Cys Ile Cys Leu Ser Lys Ala Val Gly 
                85                  90                  95      


Tyr Leu Thr Gly Asp Met Lys Glu Tyr Arg Ile Trp Leu Lys Asp Lys 
            100                 105                 110         


His Leu Ala Leu Gln Phe Ile Asp Trp Val Leu Arg Gly Thr Ala Gln 
        115                 120                 125             


Val Met Phe Ile Asn Asn Pro Leu Ser Gly Leu Ile Ile Phe Ile Gly 
    130                 135                 140                 


Leu Leu Ile Gln Asn Pro Trp Trp Thr Ile Thr Gly Gly Leu Gly Thr 
145                 150                 155                 160 


Val Val Ser Thr Leu Thr Ala Leu Ala Leu Gly Gln Asp Arg Ser Ala 
                165                 170                 175     


Ile Ala Ser Gly Leu His Gly Tyr Asn Gly Met Leu Val Gly Leu Leu 
            180                 185                 190         


Met Ala Val Phe Ser Glu Lys Leu Asp Tyr Tyr Trp Trp Leu Leu Phe 
        195                 200                 205             


Pro Val Thr Phe Thr Ala Met Ser Cys Pro Val Leu Ser Ser Ala Leu 
    210                 215                 220                 


Asn Ser Ile Phe Ser Lys Trp Asp Leu Pro Val Phe Thr Leu Pro Phe 
225                 230                 235                 240 


Asn Ile Ala Val Thr Leu Tyr Leu Ala Ala Thr Gly His Tyr Asn Leu 
                245                 250                 255     


Phe Phe Pro Thr Thr Leu Val Glu Pro Val Ser Ser Val Pro Asn Ile 
            260                 265                 270         


Thr Trp Thr Glu Met Glu Met Pro Leu Leu Leu Gln Ala Ile Pro Val 
        275                 280                 285             


Gly Val Gly Gln Val Tyr Gly Cys Asp Asn Pro Trp Thr Gly Gly Val 
    290                 295                 300                 


Phe Leu Val Ala Leu Phe Ile Ser Ser Pro Leu Ile Cys Leu His Ala 
305                 310                 315                 320 


Ala Ile Gly Ser Ile Val Gly Leu Leu Ala Ala Leu Ser Val Ala Thr 
                325                 330                 335     


Pro Phe Glu Thr Ile Tyr Thr Gly Leu Trp Ser Tyr Asn Cys Val Leu 
            340                 345                 350         


Ser Cys Ile Ala Ile Gly Gly Met Phe Tyr Ala Leu Thr Trp Gln Thr 
        355                 360                 365             


His Leu Leu Ala Leu Ile Cys Ala Leu Phe Cys Ala Tyr Met Glu Ala 
    370                 375                 380                 


Ala Ile Ser Asn Ile Met Ser Val Val Gly Val Pro Pro Gly Thr Trp 
385                 390                 395                 400 


Ala Phe Cys Leu Ala Thr Ile Ile Phe Leu Leu Leu Thr Thr Asn Asn 
                405                 410                 415     


Pro Ala Ile Phe Arg Leu Pro Leu Ser Lys Val Thr Tyr Pro Glu Ala 
            420                 425                 430         


Asn Arg Ile Tyr Tyr Leu Thr Val Lys Ser Gly Glu Glu Glu Lys Ala 
        435                 440                 445             


Pro Ser Gly Gly Gly Gly Glu His Pro Pro Thr Ala Gly Pro Lys Val 
    450                 455                 460                 


Glu Glu Gly Ser Glu Ala Val Leu Ser Lys His Arg Ser Val Phe His 
465                 470                 475                 480 


Ile Glu Trp Ser Ser Ile Arg Arg Arg Ser Lys Val Phe Gly Lys Gly 
                485                 490                 495     


Glu His Gln Glu Arg Gln Asn Lys Asp Pro Phe Pro Tyr Arg Tyr Arg 
            500                 505                 510         


Lys Pro Thr Val Glu Leu Leu Asp Leu Asp Thr Met Glu Glu Ser Ser 
        515                 520                 525             


Glu Ile Lys Val Glu Thr Asn Ile Ser Lys Thr Ser Trp Ile Arg Ser 
    530                 535                 540                 


Ser Met Ala Ala Ser Gly Lys Arg Val Ser Lys Ala Leu Ser Tyr Ile 
545                 550                 555                 560 


Thr Gly Glu Met Lys Glu Cys Gly Glu Gly Leu Lys Asp Lys Ser Pro 
                565                 570                 575     


Val Phe Gln Phe Phe Asp Trp Val Leu Arg Gly Thr Ser Gln Val Met 
            580                 585                 590         


Phe Val Asn Asn Pro Leu Ser Gly Ile Leu Ile Ile Leu Gly Leu Phe 
        595                 600                 605             


Ile Gln Asn Pro Trp Trp Ala Ile Ser Gly Cys Leu Gly Thr Ile Met 
    610                 615                 620                 


Ser Thr Leu Thr Ala Leu Ile Leu Ser Gln Asp Lys Ser Ala Ile Ala 
625                 630                 635                 640 


Ala Gly Phe His Gly Tyr Asn Gly Val Leu Val Gly Leu Leu Met Ala 
                645                 650                 655     


Val Phe Ser Asp Lys Gly Asp Tyr Tyr Trp Trp Leu Leu Leu Pro Val 
            660                 665                 670         


Ile Ile Met Ser Met Ser Cys Pro Ile Leu Ser Ser Ala Leu Gly Thr 
        675                 680                 685             


Ile Phe Ser Lys Trp Asp Leu Pro Val Phe Thr Leu Pro Phe Asn Ile 
    690                 695                 700                 


Thr Val Thr Leu Tyr Leu Ala Ala Thr Gly His Tyr Asn Leu Phe Phe 
705                 710                 715                 720 


Pro Thr Thr Leu Leu Gln Pro Ala Ser Ala Met Pro Asn Ile Thr Trp 
                725                 730                 735     


Ser Glu Val Gln Val Pro Leu Leu Leu Arg Ala Ile Pro Val Gly Ile 
            740                 745                 750         


Gly Gln Val Tyr Gly Cys Asp Asn Pro Trp Thr Gly Gly Ile Phe Leu 
        755                 760                 765             


Ile Ala Leu Phe Ile Ser Ser Pro Leu Ile Cys Leu His Ala Ala Ile 
    770                 775                 780                 


Gly Ser Thr Met Gly Met Leu Ala Ala Leu Thr Ile Ala Thr Pro Phe 
785                 790                 795                 800 


Asp Ser Ile Tyr Phe Gly Leu Cys Gly Phe Asn Ser Thr Leu Ala Cys 
                805                 810                 815     


Ile Ala Ile Gly Gly Met Phe Tyr Val Ile Thr Trp Gln Thr His Leu 
            820                 825                 830         


Leu Ala Ile Ala Cys Ala Leu Phe Ala Ala Tyr Leu Gly Ala Ala Leu 
        835                 840                 845             


Ala Asn Met Leu Ser Val Phe Gly Leu Pro Pro Cys Thr Trp Pro Phe 
    850                 855                 860                 


Cys Leu Ser Ala Leu Thr Phe Leu Leu Leu Thr Thr Asn Asn Pro Ala 
865                 870                 875                 880 


Ile Tyr Lys Leu Pro Leu Ser Lys Val Thr Tyr Pro Glu Ala Asn Arg 
                885                 890                 895     


Ile Tyr Tyr Leu Ser Gln Glu Arg Asn Arg Arg Ala Ser Ile Ile Thr 
            900                 905                 910         


Lys Tyr Gln Ala Tyr Asp Val Ser 
        915                 920 


<210>  3639
<211>  1325
<212>  PRT
<213>  Homo sapiens

<400>  3639

Met Lys Glu Pro Leu Asp Gly Glu Cys Gly Lys Ala Val Val Pro Gln 
1               5                   10                  15      


Gln Glu Leu Leu Asp Lys Ile Lys Glu Glu Pro Asp Asn Ala Gln Glu 
            20                  25                  30          


Tyr Gly Cys Val Gln Gln Pro Lys Thr Gln Glu Ser Lys Leu Lys Ile 
        35                  40                  45              


Gly Gly Val Ser Ser Val Asn Glu Arg Pro Ile Ala Gln Gln Leu Asn 
    50                  55                  60                  


Pro Gly Phe Gln Leu Ser Phe Ala Ser Ser Gly Pro Ser Val Leu Leu 
65                  70                  75                  80  


Pro Ser Val Pro Ala Val Ala Ile Lys Val Phe Cys Ser Gly Cys Lys 
                85                  90                  95      


Lys Met Leu Tyr Lys Gly Gln Thr Ala Tyr His Lys Thr Gly Ser Thr 
            100                 105                 110         


Gln Leu Phe Cys Ser Thr Arg Cys Ile Thr Arg His Ser Ser Pro Ala 
        115                 120                 125             


Cys Leu Pro Pro Pro Pro Lys Lys Thr Cys Thr Asn Cys Ser Lys Asp 
    130                 135                 140                 


Ile Leu Asn Pro Lys Asp Val Ile Thr Thr Arg Phe Glu Asn Ser Tyr 
145                 150                 155                 160 


Pro Ser Lys Asp Phe Cys Ser Gln Ser Cys Leu Ser Ser Tyr Glu Leu 
                165                 170                 175     


Lys Lys Lys Pro Val Val Thr Ile Tyr Thr Lys Ser Ile Ser Thr Lys 
            180                 185                 190         


Cys Ser Met Cys Gln Lys Asn Ala Asp Thr Arg Phe Glu Val Lys Tyr 
        195                 200                 205             


Gln Asn Val Val His Gly Leu Cys Ser Asp Ala Cys Phe Ser Lys Phe 
    210                 215                 220                 


His Ser Thr Asn Asn Leu Thr Met Asn Cys Cys Glu Asn Cys Gly Ser 
225                 230                 235                 240 


Tyr Cys Tyr Ser Ser Ser Gly Pro Cys Gln Ser Gln Lys Val Phe Ser 
                245                 250                 255     


Ser Thr Ser Val Thr Ala Tyr Lys Gln Asn Ser Ala Gln Ile Pro Pro 
            260                 265                 270         


Tyr Ala Leu Gly Lys Ser Leu Arg Pro Ser Ala Glu Met Ile Glu Thr 
        275                 280                 285             


Thr Asn Asp Ser Gly Lys Thr Glu Leu Phe Cys Ser Ile Asn Cys Leu 
    290                 295                 300                 


Ser Ala Tyr Arg Val Lys Thr Val Thr Ser Ser Gly Val Gln Val Ser 
305                 310                 315                 320 


Cys His Ser Cys Lys Thr Ser Ala Ile Pro Gln Tyr His Leu Ala Met 
                325                 330                 335     


Ser Asn Gly Thr Ile Tyr Ser Phe Cys Ser Ser Ser Cys Val Val Ala 
            340                 345                 350         


Phe Gln Asn Val Phe Ser Lys Pro Lys Gly Thr Asn Ser Ser Ala Val 
        355                 360                 365             


Pro Leu Ser Gln Gly Gln Val Val Val Ser Pro Pro Ser Ser Arg Ser 
    370                 375                 380                 


Ala Val Ser Ile Gly Gly Gly Asn Thr Ser Ala Val Ser Pro Ser Ser 
385                 390                 395                 400 


Ile Arg Gly Ser Ala Ala Ala Ser Leu Gln Pro Leu Ala Glu Gln Ser 
                405                 410                 415     


Gln Gln Val Ala Leu Thr His Thr Val Val Lys Leu Lys Cys Gln His 
            420                 425                 430         


Cys Asn His Leu Phe Ala Thr Lys Pro Glu Leu Leu Phe Tyr Lys Gly 
        435                 440                 445             


Lys Met Phe Leu Phe Cys Gly Lys Asn Cys Ser Asp Glu Tyr Lys Lys 
    450                 455                 460                 


Lys Asn Lys Val Val Ala Met Cys Asp Tyr Cys Lys Leu Gln Lys Ile 
465                 470                 475                 480 


Ile Lys Glu Thr Val Arg Phe Ser Gly Val Asp Lys Pro Phe Cys Ser 
                485                 490                 495     


Glu Val Cys Lys Phe Leu Ser Ala Arg Asp Phe Gly Glu Arg Trp Gly 
            500                 505                 510         


Asn Tyr Cys Lys Met Cys Ser Tyr Cys Ser Gln Thr Ser Pro Asn Leu 
        515                 520                 525             


Val Glu Asn Arg Leu Glu Gly Lys Leu Glu Glu Phe Cys Cys Glu Asp 
    530                 535                 540                 


Cys Met Ser Lys Phe Thr Val Leu Phe Tyr Gln Met Ala Lys Cys Asp 
545                 550                 555                 560 


Gly Cys Lys Arg Gln Gly Lys Leu Ser Glu Ser Ile Lys Trp Arg Gly 
                565                 570                 575     


Asn Ile Lys His Phe Cys Asn Leu Phe Cys Val Leu Glu Phe Cys His 
            580                 585                 590         


Gln Gln Ile Met Asn Asp Cys Leu Pro Gln Asn Lys Val Asn Ile Ser 
        595                 600                 605             


Lys Ala Lys Thr Ala Val Thr Glu Leu Pro Ser Ala Arg Thr Asp Thr 
    610                 615                 620                 


Thr Pro Val Ile Thr Ser Val Met Ser Leu Ala Lys Ile Pro Ala Thr 
625                 630                 635                 640 


Leu Ser Thr Gly Asn Thr Asn Ser Val Leu Lys Gly Ala Val Thr Lys 
                645                 650                 655     


Glu Ala Ala Lys Ile Ile Gln Asp Glu Ser Thr Gln Glu Asp Ala Met 
            660                 665                 670         


Lys Phe Pro Ser Ser Gln Ser Ser Gln Pro Ser Arg Leu Leu Lys Asn 
        675                 680                 685             


Lys Gly Ile Ser Cys Lys Pro Val Thr Gln Thr Lys Ala Thr Ser Cys 
    690                 695                 700                 


Lys Pro His Thr Gln His Lys Glu Cys Gln Thr Asp Leu Pro Met Pro 
705                 710                 715                 720 


Asn Glu Lys Asn Asp Ala Glu Leu Asp Ser Pro Pro Ser Lys Lys Lys 
                725                 730                 735     


Arg Leu Gly Phe Phe Gln Thr Tyr Asp Thr Glu Tyr Leu Lys Val Gly 
            740                 745                 750         


Phe Ile Ile Cys Pro Gly Ser Lys Glu Ser Ser Pro Arg Pro Gln Cys 
        755                 760                 765             


Val Ile Cys Gly Glu Ile Leu Ser Ser Glu Asn Met Lys Pro Ala Asn 
    770                 775                 780                 


Leu Ser His His Leu Lys Thr Lys His Ser Glu Leu Glu Asn Lys Pro 
785                 790                 795                 800 


Val Asp Phe Phe Glu Gln Lys Ser Leu Glu Met Glu Cys Gln Asn Ser 
                805                 810                 815     


Ser Leu Lys Lys Cys Leu Leu Val Glu Lys Ser Leu Val Lys Ala Ser 
            820                 825                 830         


Tyr Leu Ile Ala Phe Gln Thr Ala Ala Ser Lys Lys Pro Phe Ser Ile 
        835                 840                 845             


Ala Glu Glu Leu Ile Lys Pro Tyr Leu Val Glu Met Cys Ser Glu Val 
    850                 855                 860                 


Leu Gly Ser Ser Ala Gly Asp Lys Met Lys Thr Ile Pro Leu Ser Asn 
865                 870                 875                 880 


Val Thr Ile Gln His Arg Ile Asp Glu Leu Ser Ala Asp Ile Glu Asp 
                885                 890                 895     


Gln Leu Ile Gln Lys Val Arg Glu Ser Lys Trp Phe Ala Leu Gln Ile 
            900                 905                 910         


Asp Glu Ser Ser Glu Ile Ser Asn Ile Thr Leu Leu Leu Cys Tyr Ile 
        915                 920                 925             


Arg Phe Ile Asp Tyr Asp Cys Arg Asp Val Lys Glu Glu Leu Leu Phe 
    930                 935                 940                 


Cys Ile Glu Met Pro Thr Gln Ile Thr Gly Phe Glu Ile Phe Glu Leu 
945                 950                 955                 960 


Ile Asn Lys Tyr Ile Asp Ser Lys Ser Leu Asn Trp Lys His Cys Val 
                965                 970                 975     


Gly Leu Cys Thr Asp Gly Ala Ala Ser Met Thr Gly Arg Tyr Ser Gly 
            980                 985                 990         


Leu Lys Ala Lys Ile Gln Glu Val  Ala Met Asn Thr Ala  Ala Phe Thr 
        995                 1000                 1005             


His Cys  Phe Ile His Arg Glu  Arg Leu Val Ala Glu  Lys Leu Ser 
    1010                 1015                 1020             


Pro Cys  Leu His Lys Ile Leu  Leu Gln Ser Ala Gln  Ile Leu Ser 
    1025                 1030                 1035             


Phe Ile  Lys Ser Asn Ala Leu  Asn Ser Arg Met Leu  Thr Ile Leu 
    1040                 1045                 1050             


Cys Glu  Glu Met Gly Ser Glu  His Val Ser Leu Pro  Leu His Ala 
    1055                 1060                 1065             


Glu Val  Arg Trp Ile Ser Arg  Gly Arg Met Leu Lys  Arg Leu Phe 
    1070                 1075                 1080             


Glu Leu  Arg His Glu Ile Glu  Ile Phe Leu Ser Gln  Lys His Ser 
    1085                 1090                 1095             


Asp Leu  Ala Lys Tyr Phe His  Asp Glu Glu Trp Val  Gly Lys Leu 
    1100                 1105                 1110             


Ala Tyr  Leu Ser Asp Ile Phe  Ser Leu Ile Asn Glu  Leu Asn Leu 
    1115                 1120                 1125             


Ser Leu  Gln Gly Thr Leu Thr  Thr Phe Phe Asn Leu  Cys Asn Lys 
    1130                 1135                 1140             


Ile Asp  Val Phe Lys Arg Lys  Leu Lys Met Trp Leu  Lys Arg Thr 
    1145                 1150                 1155             


Gln Glu  Asn Asp Tyr Asp Met  Phe Pro Ser Phe Ser  Glu Phe Ser 
    1160                 1165                 1170             


Asn Ser  Ser Gly Leu Asn Met  Thr Asp Ile Thr Arg  Ile Ile Phe 
    1175                 1180                 1185             


Glu His  Leu Glu Gly Leu Ser  Gln Val Phe Ser Asp  Cys Phe Pro 
    1190                 1195                 1200             


Pro Glu  Gln Asp Leu Arg Ser  Gly Asn Leu Trp Ile  Ile His Pro 
    1205                 1210                 1215             


Phe Met  Asn His Gln Asn Asn  Asn Leu Thr Asp Phe  Glu Glu Glu 
    1220                 1225                 1230             


Lys Leu  Thr Glu Leu Ser Ser  Asp Leu Gly Leu Gln  Ala Leu Phe 
    1235                 1240                 1245             


Lys Ser  Val Ser Val Thr Gln  Phe Trp Ile Asn Ala  Lys Thr Ser 
    1250                 1255                 1260             


Tyr Pro  Glu Leu His Glu Arg  Ala Met Lys Phe Leu  Leu Pro Phe 
    1265                 1270                 1275             


Ser Thr  Val Tyr Leu Cys Asp  Ala Ala Phe Ser Ala  Leu Thr Glu 
    1280                 1285                 1290             


Ser Lys  Gln Lys Asn Leu Leu  Gly Ser Gly Pro Ala  Leu Arg Leu 
    1295                 1300                 1305             


Ala Val  Thr Ser Leu Ile Pro  Arg Ile Glu Lys Leu  Val Lys Glu 
    1310                 1315                 1320             


Lys Glu  
    1325 


<210>  3640
<211>  1581
<212>  PRT
<213>  Homo sapiens

<400>  3640

Met Arg Lys Arg Lys Ile Ser Val Cys Gln Gln Thr Trp Ala Leu Leu 
1               5                   10                  15      


Cys Lys Asn Phe Leu Lys Lys Trp Arg Met Lys Arg Glu Ser Leu Met 
            20                  25                  30          


Glu Trp Leu Asn Ser Leu Leu Leu Leu Leu Cys Leu Tyr Ile Tyr Pro 
        35                  40                  45              


His Ser His Gln Val Asn Asp Phe Ser Ser Leu Leu Thr Met Asp Leu 
    50                  55                  60                  


Gly Arg Val Asp Thr Phe Asn Glu Ser Arg Phe Ser Val Val Tyr Thr 
65                  70                  75                  80  


Pro Val Thr Asn Thr Thr Gln Gln Ile Met Asn Lys Val Ala Ser Thr 
                85                  90                  95      


Pro Phe Leu Ala Gly Lys Glu Val Leu Gly Leu Pro Asp Glu Glu Ser 
            100                 105                 110         


Ile Lys Glu Phe Thr Ala Asn Tyr Pro Glu Glu Ile Val Arg Val Thr 
        115                 120                 125             


Phe Thr Asn Thr Tyr Ser Tyr His Leu Lys Phe Leu Leu Gly His Gly 
    130                 135                 140                 


Met Pro Ala Lys Lys Glu His Lys Asp His Thr Ala His Cys Tyr Glu 
145                 150                 155                 160 


Thr Asn Glu Asp Val Tyr Cys Glu Val Ser Val Phe Trp Lys Glu Gly 
                165                 170                 175     


Phe Val Ala Leu Gln Ala Ala Ile Asn Ala Ala Ile Ile Glu Ile Thr 
            180                 185                 190         


Thr Asn His Ser Val Met Glu Glu Leu Met Ser Val Thr Gly Lys Asn 
        195                 200                 205             


Met Lys Met His Ser Phe Ile Gly Gln Ser Gly Val Ile Thr Asp Leu 
    210                 215                 220                 


Tyr Leu Phe Ser Cys Ile Ile Ser Phe Ser Ser Phe Ile Tyr Tyr Ala 
225                 230                 235                 240 


Ser Val Asn Val Thr Arg Glu Arg Lys Arg Met Lys Ala Leu Met Thr 
                245                 250                 255     


Met Met Gly Leu Arg Asp Ser Ala Phe Trp Leu Ser Trp Gly Leu Leu 
            260                 265                 270         


Tyr Ala Gly Phe Ile Phe Ile Met Ala Leu Phe Leu Ala Leu Val Ile 
        275                 280                 285             


Arg Ser Thr Gln Phe Ile Ile Leu Ser Gly Phe Met Val Val Phe Ser 
    290                 295                 300                 


Leu Phe Leu Leu Tyr Gly Leu Ser Leu Val Ala Leu Ala Phe Leu Met 
305                 310                 315                 320 


Ser Ile Leu Val Lys Lys Ser Phe Leu Thr Gly Leu Val Val Phe Leu 
                325                 330                 335     


Leu Thr Val Phe Trp Gly Cys Leu Gly Phe Thr Ser Leu Tyr Arg His 
            340                 345                 350         


Leu Pro Ala Ser Leu Glu Trp Ile Leu Ser Leu Leu Ser Pro Phe Ala 
        355                 360                 365             


Phe Met Leu Gly Met Ala Gln Leu Leu His Leu Asp Tyr Asp Leu Asn 
    370                 375                 380                 


Ser Asn Ala Phe Pro His Pro Ser Asp Gly Ser Asn Leu Ile Val Ala 
385                 390                 395                 400 


Thr Asn Phe Met Leu Ala Phe Asp Thr Cys Leu Tyr Leu Ala Leu Ala 
                405                 410                 415     


Ile Tyr Phe Glu Lys Ile Leu Pro Asn Glu Tyr Gly His Arg Arg Pro 
            420                 425                 430         


Pro Leu Phe Phe Leu Lys Ser Ser Phe Trp Ser Gln Thr Gln Lys Thr 
        435                 440                 445             


Asp His Val Ala Leu Glu Asp Glu Met Asp Ala Asp Pro Ser Phe His 
    450                 455                 460                 


Asp Ser Phe Glu Gln Ala Pro Pro Glu Phe Gln Gly Lys Glu Ala Ile 
465                 470                 475                 480 


Arg Ile Arg Asn Val Thr Lys Glu Tyr Lys Gly Lys Pro Asp Lys Ile 
                485                 490                 495     


Glu Ala Leu Lys Asp Leu Val Phe Asp Ile Tyr Glu Gly Gln Ile Thr 
            500                 505                 510         


Ala Ile Leu Gly His Ser Gly Ala Gly Lys Ser Thr Leu Leu Asn Ile 
        515                 520                 525             


Leu Ser Gly Leu Ser Val Pro Thr Lys Gly Ser Val Thr Ile Tyr Asn 
    530                 535                 540                 


Asn Lys Leu Ser Glu Met Ala Asp Leu Glu Asn Leu Ser Lys Leu Thr 
545                 550                 555                 560 


Gly Val Cys Pro Gln Ser Asn Val Gln Phe Asp Phe Leu Thr Val Arg 
                565                 570                 575     


Glu Asn Leu Arg Leu Phe Ala Lys Ile Lys Gly Ile Leu Pro Gln Glu 
            580                 585                 590         


Val Asp Lys Glu Ile Phe Leu Leu Asp Glu Pro Thr Ala Gly Leu Asp 
        595                 600                 605             


Pro Phe Ser Arg His Gln Val Trp Asn Leu Leu Lys Glu Arg Lys Thr 
    610                 615                 620                 


Asp Arg Val Ile Leu Phe Ser Thr Gln Phe Met Asp Glu Ala Asp Ile 
625                 630                 635                 640 


Leu Ala Asp Arg Lys Val Phe Leu Ser Gln Gly Lys Leu Lys Cys Ala 
                645                 650                 655     


Gly Ser Ser Leu Phe Leu Lys Lys Lys Trp Gly Ile Gly Tyr His Leu 
            660                 665                 670         


Ser Leu Gln Leu Asn Glu Ile Cys Val Glu Glu Asn Ile Thr Ser Leu 
        675                 680                 685             


Val Lys Gln His Ile Pro Asp Ala Lys Leu Ser Ala Lys Ser Glu Gly 
    690                 695                 700                 


Lys Leu Ile Tyr Thr Leu Pro Leu Glu Arg Thr Asn Lys Phe Pro Glu 
705                 710                 715                 720 


Leu Tyr Lys Asp Leu Asp Ser Tyr Pro Asp Leu Gly Ile Glu Asn Tyr 
                725                 730                 735     


Gly Val Ser Met Thr Thr Leu Asn Glu Val Phe Leu Lys Leu Glu Gly 
            740                 745                 750         


Lys Ser Thr Ile Asn Glu Ser Asp Ile Ala Ile Leu Gly Glu Val Gln 
        755                 760                 765             


Ala Glu Lys Ala Asp Asp Thr Glu Arg Leu Val Glu Met Glu Gln Val 
    770                 775                 780                 


Leu Ser Ser Leu Asn Lys Met Arg Lys Thr Ile Gly Gly Val Ala Leu 
785                 790                 795                 800 


Trp Arg Gln Gln Ile Cys Ala Ile Ala Arg Val Arg Leu Leu Lys Leu 
                805                 810                 815     


Lys His Glu Arg Lys Ala Leu Leu Ala Leu Leu Leu Ile Leu Met Ala 
            820                 825                 830         


Gly Phe Cys Pro Leu Leu Val Glu Tyr Thr Met Val Lys Ile Tyr Gln 
        835                 840                 845             


Asn Ser Tyr Thr Trp Glu Leu Ser Pro His Leu Tyr Phe Leu Ala Pro 
    850                 855                 860                 


Gly Gln Gln Pro His Asp Pro Leu Thr Gln Leu Leu Ile Ile Asn Lys 
865                 870                 875                 880 


Thr Gly Ala Ser Ile Asp Asp Phe Ile Gln Ser Val Glu His Gln Asn 
                885                 890                 895     


Ile Ala Leu Glu Val Asp Ala Phe Gly Thr Arg Asn Gly Thr Asp Asp 
            900                 905                 910         


Pro Ser Tyr Asn Gly Ala Ile Thr Val Cys Cys Asn Glu Lys Asn Tyr 
        915                 920                 925             


Ser Phe Ser Leu Ala Cys Asn Ala Lys Arg Leu Asn Cys Phe Pro Val 
    930                 935                 940                 


Leu Met Asp Ile Val Ser Asn Gly Leu Leu Gly Met Val Lys Pro Ser 
945                 950                 955                 960 


Val His Ile Arg Thr Glu Arg Ser Thr Phe Leu Glu Asn Gly Gln Asp 
                965                 970                 975     


Asn Pro Ile Gly Phe Leu Ala Tyr Ile Met Phe Trp Leu Val Leu Thr 
            980                 985                 990         


Ser Ser Cys Pro Pro Tyr Ile Ala  Met Ser Ser Ile Asp  Asp Tyr Lys 
        995                 1000                 1005             


Asn Arg  Ala Arg Ser Gln Leu  Arg Ile Ser Gly Leu  Ser Pro Ser 
    1010                 1015                 1020             


Ala Tyr  Trp Phe Gly Gln Ala  Leu Val Asp Val Ser  Leu Tyr Phe 
    1025                 1030                 1035             


Leu Val  Phe Val Phe Ile Tyr  Leu Met Ser Tyr Ile  Ser Asn Phe 
    1040                 1045                 1050             


Glu Asp  Met Leu Leu Thr Ile  Ile His Ile Ile Gln  Ile Pro Cys 
    1055                 1060                 1065             


Ala Val  Gly Tyr Ser Phe Ser  Leu Ile Phe Met Thr  Tyr Val Ile 
    1070                 1075                 1080             


Ser Phe  Ile Phe Arg Lys Gly  Arg Lys Asn Ser Gly  Ile Trp Ser 
    1085                 1090                 1095             


Phe Cys  Phe Tyr Val Val Thr  Val Phe Ser Val Ala  Gly Phe Ala 
    1100                 1105                 1110             


Phe Ser  Ile Phe Glu Ser Asp  Ile Pro Phe Ile Phe  Thr Phe Leu 
    1115                 1120                 1125             


Ile Pro  Pro Ala Thr Met Ile  Gly Cys Leu Phe Leu  Ser Ser His 
    1130                 1135                 1140             


Leu Leu  Phe Ser Ser Leu Phe  Ser Glu Glu Arg Met  Asp Val Gln 
    1145                 1150                 1155             


Pro Phe  Leu Val Phe Leu Ile  Pro Phe Leu His Phe  Ile Ile Phe 
    1160                 1165                 1170             


Leu Phe  Thr Leu Arg Cys Leu  Glu Trp Lys Phe Gly  Lys Lys Ser 
    1175                 1180                 1185             


Met Arg  Lys Asp Pro Phe Phe  Arg Ile Ser Pro Arg  Ser Ser Asp 
    1190                 1195                 1200             


Val Cys  Gln Asn Pro Glu Glu  Pro Glu Gly Glu Asp  Glu Asp Val 
    1205                 1210                 1215             


Gln Met  Glu Arg Val Arg Thr  Ala Asn Ala Leu Asn  Ser Thr Asn 
    1220                 1225                 1230             


Phe Asp  Glu Lys Pro Val Ile  Ile Ala Ser Cys Leu  Arg Lys Glu 
    1235                 1240                 1245             


Tyr Ala  Gly Lys Arg Lys Gly  Cys Phe Ser Lys Arg  Lys Asn Lys 
    1250                 1255                 1260             


Ile Ala  Thr Arg Asn Val Ser  Phe Cys Val Arg Lys  Gly Glu Val 
    1265                 1270                 1275             


Leu Gly  Leu Leu Gly His Asn  Gly Ala Gly Lys Ser  Thr Ser Ile 
    1280                 1285                 1290             


Lys Val  Ile Thr Gly Asp Thr  Lys Pro Thr Ala Gly  Gln Val Leu 
    1295                 1300                 1305             


Leu Lys  Gly Ser Gly Gly Gly  Asp Ala Leu Glu Phe  Leu Gly Tyr 
    1310                 1315                 1320             


Cys Pro  Gln Glu Asn Ala Leu  Trp Pro Asn Leu Thr  Val Arg Gln 
    1325                 1330                 1335             


His Leu  Glu Val Tyr Ala Ala  Val Lys Gly Leu Arg  Lys Gly Asp 
    1340                 1345                 1350             


Ala Glu  Val Ala Ile Thr Arg  Leu Val Asp Ala Leu  Lys Leu Gln 
    1355                 1360                 1365             


Asp Gln  Leu Lys Ser Pro Val  Lys Thr Leu Ser Glu  Gly Ile Lys 
    1370                 1375                 1380             


Arg Lys  Leu Cys Phe Val Leu  Ser Ile Leu Gly Asn  Pro Ser Val 
    1385                 1390                 1395             


Val Leu  Leu Asp Glu Pro Ser  Thr Gly Met Asp Pro  Glu Gly Gln 
    1400                 1405                 1410             


Gln Gln  Met Trp Gln Ala Ile  Arg Ala Thr Phe Arg  Asn Thr Glu 
    1415                 1420                 1425             


Arg Gly  Ala Leu Leu Thr Thr  His Tyr Met Ala Glu  Ala Glu Ala 
    1430                 1435                 1440             


Val Cys  Asp Arg Val Ala Ile  Met Val Ser Gly Arg  Leu Arg Cys 
    1445                 1450                 1455             


Ile Gly  Ser Ile Gln His Leu  Lys Ser Lys Phe Gly  Lys Asp Tyr 
    1460                 1465                 1470             


Leu Leu  Glu Met Lys Val Lys  Asn Leu Ala Gln Val  Glu Pro Leu 
    1475                 1480                 1485             


His Ala  Glu Ile Leu Arg Leu  Phe Pro Gln Ala Ala  Arg Gln Glu 
    1490                 1495                 1500             


Arg Tyr  Ser Ser Leu Met Val  Tyr Lys Leu Pro Val  Glu Asp Val 
    1505                 1510                 1515             


Gln Pro  Leu Ala Gln Ala Phe  Phe Lys Leu Glu Lys  Val Lys Gln 
    1520                 1525                 1530             


Ser Phe  Asp Leu Glu Glu Tyr  Ser Leu Ser Gln Ser  Thr Leu Glu 
    1535                 1540                 1545             


Gln Val  Phe Leu Glu Leu Ser  Lys Glu Gln Glu Leu  Gly Asp Phe 
    1550                 1555                 1560             


Glu Glu  Asp Phe Asp Pro Ser  Val Lys Trp Lys Leu  Leu Pro Gln 
    1565                 1570                 1575             


Glu Glu  Pro 
    1580     


<210>  3641
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  3641

Met Thr Arg Leu Leu Gly Tyr Val Asp Pro Leu Asp Pro Ser Phe Val 
1               5                   10                  15      


Ala Ala Val Ile Thr Ile Thr Phe Asn Pro Leu Tyr Trp Asn Val Val 
            20                  25                  30          


Ala Arg Trp Glu His Lys Thr Arg Lys Leu Ser Arg Ala Phe Gly Ser 
        35                  40                  45              


Pro Tyr Leu Ala Cys Tyr Ser Leu Ser Val Thr Ile Leu Leu Leu Asn 
    50                  55                  60                  


Phe Leu Arg Ser His Cys Phe Thr Gln Ala Met Leu Ser Gln Pro Arg 
65                  70                  75                  80  


Met Glu Ser Leu Asp Thr Pro Ala Ala Tyr Ser Leu Gly Leu Ala Leu 
                85                  90                  95      


Leu Gly Leu Gly Val Val Leu Val Leu Ser Ser Phe Phe Ala Leu Gly 
            100                 105                 110         


Phe Ala Gly Thr Phe Leu Gly Asp Tyr Phe Gly Ile Leu Lys Glu Ala 
        115                 120                 125             


Arg Val Thr Val Phe Pro Phe Asn Ile Leu Asp Asn Pro Met Tyr Trp 
    130                 135                 140                 


Gly Ser Thr Ala Asn Tyr Leu Gly Trp Ala Ile Met His Ala Ser Pro 
145                 150                 155                 160 


Thr Gly Leu Leu Leu Thr Val Leu Val Ala Leu Thr Tyr Ile Val Ala 
                165                 170                 175     


Leu Leu Tyr Glu Glu Pro Phe Thr Ala Glu Ile Tyr Arg Gln Lys Ala 
            180                 185                 190         


Ser Gly Ser His Lys Arg Ser 
        195                 


<210>  3642
<211>  747
<212>  PRT
<213>  Homo sapiens

<400>  3642

Met Trp Gly Phe Leu Lys Arg Pro Val Val Val Thr Ala Asp Ile Asn 
1               5                   10                  15      


Leu Ser Leu Val Ala Leu Thr Gly Met Gly Leu Leu Ser Arg Leu Trp 
            20                  25                  30          


Arg Leu Thr Tyr Pro Arg Ala Val Val Phe Asp Glu Val Tyr Tyr Gly 
        35                  40                  45              


Gln Tyr Ile Ser Phe Tyr Met Lys Gln Ile Phe Phe Leu Asp Asp Ser 
    50                  55                  60                  


Gly Pro Pro Phe Gly His Met Val Leu Ala Leu Gly Gly Tyr Leu Gly 
65                  70                  75                  80  


Gly Phe Asp Gly Asn Phe Leu Trp Asn Arg Ile Gly Ala Glu Tyr Ser 
                85                  90                  95      


Ser Asn Val Pro Val Trp Ser Leu Arg Leu Leu Pro Ala Leu Ala Gly 
            100                 105                 110         


Ala Leu Ser Val Pro Met Ala Tyr Gln Ile Val Leu Glu Leu His Phe 
        115                 120                 125             


Ser His Cys Ala Ala Met Gly Ala Ala Leu Leu Met Leu Ile Glu Asn 
    130                 135                 140                 


Ala Leu Ile Thr Gln Ser Arg Leu Met Leu Leu Glu Ser Val Leu Ile 
145                 150                 155                 160 


Phe Phe Asn Leu Leu Ala Val Leu Ser Tyr Leu Lys Phe Phe Asn Cys 
                165                 170                 175     


Gln Lys His Ser Pro Phe Ser Leu Ser Trp Trp Phe Trp Leu Thr Leu 
            180                 185                 190         


Thr Gly Val Ala Cys Ser Cys Ala Val Gly Ile Lys Tyr Met Gly Val 
        195                 200                 205             


Phe Thr Tyr Val Leu Val Leu Gly Val Ala Ala Val His Ala Trp His 
    210                 215                 220                 


Leu Leu Gly Asp Gln Thr Leu Ser Asn Val Gly Ala Asp Val Gln Cys 
225                 230                 235                 240 


Cys Met Arg Pro Ala Cys Met Gly Gln Met Arg Met Ser Gln Gly Val 
                245                 250                 255     


Cys Val Phe Cys His Leu Leu Ala Arg Ala Val Ala Leu Leu Val Ile 
            260                 265                 270         


Pro Val Val Leu Tyr Leu Leu Phe Phe Tyr Val His Leu Ile Leu Val 
        275                 280                 285             


Phe Arg Ser Gly Pro His Asp Gln Ile Met Ser Ser Ala Phe Gln Ala 
    290                 295                 300                 


Ser Leu Glu Gly Gly Leu Ala Arg Ile Thr Gln Gly Gln Pro Leu Glu 
305                 310                 315                 320 


Val Ala Phe Gly Ser Gln Val Thr Leu Arg Asn Val Phe Gly Lys Pro 
                325                 330                 335     


Val Pro Cys Trp Leu His Ser His Gln Asp Thr Tyr Pro Met Ile Tyr 
            340                 345                 350         


Glu Asn Gly Arg Gly Ser Ser His Gln Gln Gln Val Thr Cys Tyr Pro 
        355                 360                 365             


Phe Lys Asp Val Asn Asn Trp Trp Ile Val Lys Asp Pro Arg Arg His 
    370                 375                 380                 


Gln Leu Val Val Ser Ser Pro Pro Arg Pro Val Arg His Gly Asp Met 
385                 390                 395                 400 


Val Gln Leu Val His Gly Met Thr Thr Arg Ser Leu Asn Thr His Asp 
                405                 410                 415     


Val Ala Ala Pro Leu Ser Pro His Ser Gln Glu Val Ser Cys Tyr Ile 
            420                 425                 430         


Asp Tyr Asn Ile Ser Met Pro Ala Gln Asn Leu Trp Arg Leu Glu Ile 
        435                 440                 445             


Val Asn Arg Gly Ser Asp Thr Asp Val Trp Lys Thr Ile Leu Ser Glu 
    450                 455                 460                 


Val Arg Phe Val His Val Asn Thr Ser Ala Val Leu Lys Leu Ser Gly 
465                 470                 475                 480 


Ala His Leu Pro Asp Trp Gly Tyr Arg Gln Leu Glu Ile Val Gly Glu 
                485                 490                 495     


Lys Leu Ser Arg Gly Tyr His Gly Ser Thr Val Trp Asn Val Glu Glu 
            500                 505                 510         


His Arg Tyr Gly Ala Ser Gln Glu Gln Arg Glu Arg Glu Arg Glu Leu 
        515                 520                 525             


His Ser Pro Ala Gln Val Asp Val Ser Arg Asn Leu Ser Phe Met Ala 
    530                 535                 540                 


Arg Phe Ser Glu Leu Gln Trp Arg Met Leu Ala Leu Arg Ser Asp Asp 
545                 550                 555                 560 


Ser Glu His Lys Tyr Ser Ser Ser Pro Leu Glu Trp Val Thr Leu Asp 
                565                 570                 575     


Thr Asn Ile Ala Tyr Trp Leu His Pro Arg Thr Ser Ala Gln Ile His 
            580                 585                 590         


Leu Leu Gly Asn Ile Val Ile Trp Val Ser Gly Ser Leu Ala Leu Ala 
        595                 600                 605             


Ile Tyr Ala Leu Leu Ser Leu Trp Tyr Leu Leu Arg Arg Arg Arg Asn 
    610                 615                 620                 


Val His Asp Leu Pro Gln Asp Ala Trp Leu Arg Trp Val Leu Ala Gly 
625                 630                 635                 640 


Ala Leu Cys Ala Gly Gly Trp Ala Val Asn Tyr Leu Pro Phe Phe Leu 
                645                 650                 655     


Met Glu Lys Thr Leu Phe Leu Tyr His Tyr Leu Pro Ala Leu Thr Phe 
            660                 665                 670         


Gln Ile Leu Leu Leu Pro Val Val Leu Gln His Ile Ser Asp His Leu 
        675                 680                 685             


Cys Arg Ser Gln Leu Gln Arg Ser Ile Phe Ser Ala Leu Val Val Ala 
    690                 695                 700                 


Trp Tyr Ser Ser Ala Cys His Val Ser Asn Thr Leu Arg Pro Leu Thr 
705                 710                 715                 720 


Tyr Gly Asp Lys Ser Leu Ser Pro His Glu Leu Lys Ala Leu Arg Trp 
                725                 730                 735     


Lys Asp Ser Trp Asp Ile Leu Ile Arg Lys His 
            740                 745         


<210>  3643
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  3643

Met Ala Lys Arg Asn Ala Glu Lys Glu Leu Thr Asp Arg Asn Trp Asp 
1               5                   10                  15      


Gln Glu Asp Glu Ala Glu Glu Val Gly Thr Phe Ser Met Ala Ser Glu 
            20                  25                  30          


Glu Val Leu Lys Asn Arg Ala Ile Lys Lys Ala Lys Arg Arg Asn Val 
        35                  40                  45              


Gly Phe Glu Ser Asp Thr Gly Gly Ala Phe Lys Gly Phe Lys Gly Leu 
    50                  55                  60                  


Val Val Pro Ser Gly Gly Gly Arg Phe Ser Gly Phe Gly Ser Gly Ala 
65                  70                  75                  80  


Gly Gly Lys Pro Leu Glu Gly Leu Ser Asn Gly Asn Asn Ile Thr Ser 
                85                  90                  95      


Ala Pro Pro Phe Ala Ser Ala Lys Ala Ala Ala Asp Pro Lys Val Ala 
            100                 105                 110         


Phe Gly Ser Leu Ala Ala Asn Gly Pro Thr Thr Leu Val Asp Lys Val 
        115                 120                 125             


Ser Asn Pro Lys Thr Asn Gly Asp Ser Gln Gln Pro Ser Ser Ser Gly 
    130                 135                 140                 


Leu Ala Ser Ser Lys Ala Cys Val Gly Asn Ala Tyr His Lys Gln Leu 
145                 150                 155                 160 


Ala Ala Leu Asn Cys Ser Val Arg Asp Trp Ile Val Lys His Val Asn 
                165                 170                 175     


Thr Asn Pro Leu Cys Asp Leu Thr Pro Ile Phe Lys Asp Tyr Glu Lys 
            180                 185                 190         


Tyr Leu Ala Asn Ile Glu Gln Gln His Gly Asn Ser Gly Arg Asn Ser 
        195                 200                 205             


Glu Ser Glu Ser Asn Lys Val Ala Ala Glu Thr Gln Ser Pro Ser Leu 
    210                 215                 220                 


Phe Gly Ser Thr Lys Leu Gln Gln Glu Ser Thr Phe Leu Phe His Gly 
225                 230                 235                 240 


Asn Lys Thr Glu Asp Thr Pro Asp Lys Lys Met Glu Val Ala Ser Glu 
                245                 250                 255     


Lys Lys Thr Asp Pro Ser Ser Leu Gly Ala Thr Ser Ala Ser Phe Asn 
            260                 265                 270         


Phe Gly Lys Lys Val Asp Ser Ser Val Leu Gly Ser Leu Ser Ser Val 
        275                 280                 285             


Pro Leu Thr Gly Phe Ser Phe Ser Pro Gly Asn Ser Ser Leu Phe Gly 
    290                 295                 300                 


Lys Asp Thr Thr Gln Ser Lys Pro Val Ser Ser Pro Phe Pro Thr Lys 
305                 310                 315                 320 


Pro Leu Glu Gly Gln Ala Glu Gly Asp Ser Gly Glu Cys Lys Gly Gly 
                325                 330                 335     


Asp Glu Glu Glu Asn Asp Glu Pro Pro Lys Val Val Val Thr Glu Val 
            340                 345                 350         


Lys Glu Glu Asp Ala Phe Tyr Ser Lys Lys Cys Lys Leu Phe Tyr Lys 
        355                 360                 365             


Lys Asp Asn Glu Phe Lys Glu Lys Gly Ile Gly Thr Leu His Leu Lys 
    370                 375                 380                 


Pro Thr Ala Asn Gln Lys Thr Gln Leu Leu Val Arg Ala Asp Thr Asn 
385                 390                 395                 400 


Leu Gly Asn Ile Leu Leu Asn Val Leu Ile Pro Pro Asn Met Pro Cys 
                405                 410                 415     


Thr Arg Thr Gly Lys Asn Asn Val Leu Ile Val Cys Val Pro Asn Pro 
            420                 425                 430         


Pro Ile Asp Glu Lys Asn Ala Thr Met Pro Val Thr Met Leu Ile Arg 
        435                 440                 445             


Val Lys Thr Ser Glu Asp Ala Asp Glu Leu His Lys Ile Leu Leu Glu 
    450                 455                 460                 


Lys Lys Asp Ala 
465             


<210>  3644
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  3644

Met Ser Arg Phe Leu Asn Val Leu Arg Ser Trp Leu Val Met Val Ser 
1               5                   10                  15      


Ile Ile Ala Met Gly Asn Thr Leu Gln Ser Phe Arg Asp His Thr Phe 
            20                  25                  30          


Leu Tyr Glu Lys Leu Tyr Thr Gly Lys Pro Asn Leu Val Asn Gly Leu 
        35                  40                  45              


Gln Ala Arg Thr Phe Gly Ile Trp Thr Leu Leu Ser Ser Val Ile Arg 
    50                  55                  60                  


Cys Leu Cys Ala Ile Asp Ile His Asn Lys Thr Leu Tyr His Ile Thr 
65                  70                  75                  80  


Leu Trp Thr Phe Leu Leu Ala Leu Gly His Phe Leu Ser Glu Leu Phe 
                85                  90                  95      


Val Tyr Gly Thr Ala Ala Pro Thr Ile Gly Val Leu Ala Pro Leu Met 
            100                 105                 110         


Val Ala Ser Phe Ser Ile Leu Gly Met Leu Val Gly Leu Arg Tyr Leu 
        115                 120                 125             


Glu Val Glu Pro Val Ser Arg Gln Lys Lys Arg Asn 
    130                 135                 140 


<210>  3645
<211>  718
<212>  PRT
<213>  Homo sapiens

<400>  3645

Met Leu Val His Leu Phe Arg Val Gly Ile Arg Gly Gly Pro Phe Pro 
1               5                   10                  15      


Gly Arg Leu Leu Pro Pro Leu Arg Phe Gln Thr Phe Ser Ala Val Arg 
            20                  25                  30          


Tyr Ser Asp Gly Tyr Arg Ser Ser Ser Leu Leu Arg Ala Val Ala His 
        35                  40                  45              


Leu Arg Ser Gln Leu Trp Ala His Leu Pro Arg Ala Pro Leu Ala Pro 
    50                  55                  60                  


Arg Trp Ser Pro Ser Ala Trp Cys Trp Val Gly Gly Ala Leu Leu Gly 
65                  70                  75                  80  


Pro Met Val Leu Ser Lys His Pro His Leu Cys Leu Val Ala Leu Cys 
                85                  90                  95      


Glu Ala Glu Glu Ala Pro Pro Ala Ser Ser Thr Pro His Val Val Gly 
            100                 105                 110         


Ser Arg Phe Asn Trp Lys Leu Phe Trp Gln Phe Leu His Pro His Leu 
        115                 120                 125             


Leu Val Leu Gly Val Ala Val Val Leu Ala Leu Gly Ala Ala Leu Val 
    130                 135                 140                 


Asn Val Gln Ile Pro Leu Leu Leu Gly Gln Leu Val Glu Val Val Ala 
145                 150                 155                 160 


Lys Tyr Thr Arg Asp His Val Gly Ser Phe Met Thr Glu Ser Gln Asn 
                165                 170                 175     


Leu Ser Thr His Leu Leu Ile Leu Tyr Gly Val Gln Gly Leu Leu Thr 
            180                 185                 190         


Phe Gly Tyr Leu Val Leu Leu Ser His Val Gly Glu Arg Met Ala Val 
        195                 200                 205             


Asp Met Arg Arg Ala Leu Phe Ser Ser Leu Leu Arg Gln Asp Ile Thr 
    210                 215                 220                 


Phe Phe Asp Ala Asn Lys Thr Gly Gln Leu Val Ser Arg Leu Thr Thr 
225                 230                 235                 240 


Asp Val Gln Glu Phe Lys Ser Ser Phe Lys Leu Val Ile Ser Gln Gly 
                245                 250                 255     


Leu Arg Ser Cys Thr Gln Val Ala Gly Cys Leu Val Ser Leu Ser Met 
            260                 265                 270         


Leu Ser Thr Arg Leu Thr Leu Leu Leu Met Val Ala Thr Pro Ala Leu 
        275                 280                 285             


Met Gly Val Gly Thr Leu Met Gly Ser Gly Leu Arg Lys Leu Ser Arg 
    290                 295                 300                 


Gln Cys Gln Glu Gln Ile Ala Arg Ala Met Gly Val Ala Asp Glu Ala 
305                 310                 315                 320 


Leu Gly Asn Val Arg Thr Val Arg Ala Phe Ala Met Glu Gln Arg Glu 
                325                 330                 335     


Glu Glu Arg Tyr Gly Ala Glu Leu Glu Ala Cys Arg Cys Arg Ala Glu 
            340                 345                 350         


Glu Leu Gly Arg Gly Ile Ala Leu Phe Gln Gly Leu Ser Asn Ile Ala 
        355                 360                 365             


Phe Asn Cys Met Val Leu Gly Thr Leu Phe Ile Gly Gly Ser Leu Val 
    370                 375                 380                 


Ala Gly Gln Gln Leu Thr Gly Gly Asp Leu Met Ser Phe Leu Val Ala 
385                 390                 395                 400 


Ser Gln Thr Val Gln Arg Ser Met Ala Asn Leu Ser Val Leu Phe Gly 
                405                 410                 415     


Gln Val Val Arg Gly Leu Ser Ala Gly Ala Arg Val Phe Glu Tyr Met 
            420                 425                 430         


Ala Leu Asn Pro Cys Ile Pro Leu Ser Gly Gly Cys Cys Val Pro Lys 
        435                 440                 445             


Glu Gln Leu Arg Gly Ser Val Thr Phe Gln Asn Val Cys Phe Ser Tyr 
    450                 455                 460                 


Pro Cys Arg Pro Gly Phe Glu Val Leu Lys Asp Phe Thr Leu Thr Leu 
465                 470                 475                 480 


Pro Pro Gly Lys Ile Val Ala Leu Val Gly Gln Ser Gly Gly Gly Lys 
                485                 490                 495     


Thr Thr Val Ala Ser Leu Leu Glu Arg Phe Tyr Asp Pro Thr Ala Gly 
            500                 505                 510         


Val Val Met Leu Asp Gly Arg Asp Leu Arg Thr Leu Asp Pro Ser Trp 
        515                 520                 525             


Leu Arg Gly Gln Val Val Gly Phe Ile Ser Gln Glu Pro Val Leu Phe 
    530                 535                 540                 


Gly Thr Thr Ile Met Glu Asn Ile Arg Phe Gly Lys Leu Glu Ala Ser 
545                 550                 555                 560 


Asp Glu Glu Val Tyr Thr Ala Ala Arg Glu Ala Asn Ala His Glu Phe 
                565                 570                 575     


Ile Thr Ser Phe Pro Glu Gly Tyr Asn Thr Val Val Gly Glu Arg Gly 
            580                 585                 590         


Thr Thr Leu Ser Gly Gly Gln Lys Gln Arg Leu Ala Ile Ala Arg Ala 
        595                 600                 605             


Leu Ile Lys Gln Pro Thr Val Leu Ile Leu Asp Glu Ala Thr Ser Ala 
    610                 615                 620                 


Leu Asp Ala Glu Ser Glu Arg Val Val Gln Glu Ala Leu Asp Arg Ala 
625                 630                 635                 640 


Ser Ala Gly Arg Thr Val Leu Val Ile Ala His Arg Leu Ser Thr Val 
                645                 650                 655     


Arg Gly Ala His Cys Ile Val Val Met Ala Asp Gly Arg Val Trp Glu 
            660                 665                 670         


Ala Gly Thr His Glu Glu Leu Leu Lys Lys Gly Gly Leu Tyr Ala Glu 
        675                 680                 685             


Leu Ile Arg Arg Gln Ala Leu Asp Ala Pro Arg Thr Ala Ala Pro Pro 
    690                 695                 700                 


Pro Lys Lys Pro Glu Gly Pro Arg Ser His Gln His Lys Ser 
705                 710                 715             


<210>  3646
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  3646

Met Gly Arg Pro Arg Pro Arg Ala Ala Lys Thr Trp Met Phe Leu Leu 
1               5                   10                  15      


Leu Leu Gly Gly Ala Trp Ala Gly His Ser Arg Ala Gln Glu Asp Lys 
            20                  25                  30          


Val Leu Gly Gly His Glu Cys Gln Pro His Ser Gln Pro Trp Gln Ala 
        35                  40                  45              


Ala Leu Phe Gln Gly Gln Gln Leu Leu Cys Gly Gly Val Leu Val Gly 
    50                  55                  60                  


Gly Asn Trp Val Leu Thr Ala Ala His Cys Lys Lys Pro Lys Tyr Thr 
65                  70                  75                  80  


Val Arg Leu Gly Asp His Ser Leu Gln Asn Lys Asp Gly Pro Glu Gln 
                85                  90                  95      


Glu Ile Pro Val Val Gln Ser Ile Pro His Pro Cys Tyr Asn Ser Ser 
            100                 105                 110         


Asp Val Glu Asp His Asn His Asp Leu Met Leu Leu Gln Leu Arg Asp 
        115                 120                 125             


Gln Ala Ser Leu Gly Ser Lys Val Lys Pro Ile Ser Leu Ala Asp His 
    130                 135                 140                 


Cys Thr Gln Pro Gly Gln Lys Cys Thr Val Ser Gly Trp Gly Thr Val 
145                 150                 155                 160 


Thr Ser Pro Arg Glu Asn Phe Pro Asp Thr Leu Asn Cys Ala Glu Val 
                165                 170                 175     


Lys Ile Phe Pro Gln Lys Lys Cys Glu Asp Ala Tyr Pro Gly Gln Ile 
            180                 185                 190         


Thr Asp Gly Met Val Cys Ala Gly Ser Ser Lys Gly Ala Asp Thr Cys 
        195                 200                 205             


Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Asp Gly Ala Leu Gln Gly 
    210                 215                 220                 


Ile Thr Ser Trp Gly Ser Asp Pro Cys Gly Arg Ser Asp Lys Pro Gly 
225                 230                 235                 240 


Val Tyr Thr Asn Ile Cys Arg Tyr Leu Asp Trp Ile Lys Lys Ile Ile 
                245                 250                 255     


Gly Ser Lys Gly 
            260 


<210>  3647
<211>  581
<212>  PRT
<213>  Homo sapiens

<400>  3647

Met Gln Arg Pro Gly Pro Arg Leu Trp Leu Val Leu Gln Val Met Gly 
1               5                   10                  15      


Ser Cys Ala Ala Ile Ser Ser Met Asp Met Glu Arg Pro Gly Asp Gly 
            20                  25                  30          


Lys Cys Gln Pro Ile Glu Ile Pro Met Cys Lys Asp Ile Gly Tyr Asn 
        35                  40                  45              


Met Thr Arg Met Pro Asn Leu Met Gly His Glu Asn Gln Arg Glu Ala 
    50                  55                  60                  


Ala Ile Gln Leu His Glu Phe Ala Pro Leu Val Glu Tyr Gly Cys His 
65                  70                  75                  80  


Gly His Leu Arg Phe Phe Leu Cys Ser Leu Tyr Ala Pro Met Cys Thr 
                85                  90                  95      


Glu Gln Val Ser Thr Pro Ile Pro Ala Cys Arg Val Met Cys Glu Gln 
            100                 105                 110         


Ala Arg Leu Lys Cys Ser Pro Ile Met Glu Gln Phe Asn Phe Lys Trp 
        115                 120                 125             


Pro Asp Ser Leu Asp Cys Arg Lys Leu Pro Asn Lys Asn Asp Pro Asn 
    130                 135                 140                 


Tyr Leu Cys Met Glu Ala Pro Asn Asn Gly Ser Asp Glu Pro Thr Arg 
145                 150                 155                 160 


Gly Ser Gly Leu Phe Pro Pro Leu Phe Arg Pro Gln Arg Pro His Ser 
                165                 170                 175     


Ala Gln Glu His Pro Leu Lys Asp Gly Gly Pro Gly Arg Gly Gly Cys 
            180                 185                 190         


Asp Asn Pro Gly Lys Phe His His Val Glu Lys Ser Ala Ser Cys Ala 
        195                 200                 205             


Pro Leu Cys Thr Pro Gly Val Asp Val Tyr Trp Ser Arg Glu Asp Lys 
    210                 215                 220                 


Arg Phe Ala Val Val Trp Leu Ala Ile Trp Ala Val Leu Cys Phe Phe 
225                 230                 235                 240 


Ser Ser Ala Phe Thr Val Leu Thr Phe Leu Ile Asp Pro Ala Arg Phe 
                245                 250                 255     


Arg Tyr Pro Glu Arg Pro Ile Ile Phe Leu Ser Met Cys Tyr Cys Val 
            260                 265                 270         


Tyr Ser Val Gly Tyr Leu Ile Arg Leu Phe Ala Gly Ala Glu Ser Ile 
        275                 280                 285             


Ala Cys Asp Arg Asp Ser Gly Gln Leu Tyr Val Ile Gln Glu Gly Leu 
    290                 295                 300                 


Glu Ser Thr Gly Cys Thr Leu Val Phe Leu Val Leu Tyr Tyr Phe Gly 
305                 310                 315                 320 


Met Ala Ser Ser Leu Trp Trp Val Val Leu Thr Leu Thr Trp Phe Leu 
                325                 330                 335     


Ala Ala Gly Lys Lys Trp Gly His Glu Ala Ile Glu Ala Asn Ser Ser 
            340                 345                 350         


Tyr Phe His Leu Ala Ala Trp Ala Ile Pro Ala Val Lys Thr Ile Leu 
        355                 360                 365             


Ile Leu Val Met Arg Arg Val Ala Gly Asp Glu Leu Thr Gly Val Cys 
    370                 375                 380                 


Tyr Val Gly Ser Met Asp Val Asn Ala Leu Thr Gly Phe Val Leu Ile 
385                 390                 395                 400 


Pro Leu Ala Cys Tyr Leu Val Ile Gly Thr Ser Phe Ile Leu Ser Gly 
                405                 410                 415     


Phe Val Ala Leu Phe His Ile Arg Arg Val Met Lys Thr Gly Gly Glu 
            420                 425                 430         


Asn Thr Asp Lys Leu Glu Lys Leu Met Val Arg Ile Gly Leu Phe Ser 
        435                 440                 445             


Val Leu Tyr Thr Val Pro Ala Thr Cys Val Ile Ala Cys Tyr Phe Tyr 
    450                 455                 460                 


Glu Arg Leu Asn Met Asp Tyr Trp Lys Ile Leu Ala Ala Gln His Lys 
465                 470                 475                 480 


Cys Lys Met Asn Asn Gln Thr Lys Thr Leu Asp Cys Leu Met Ala Ala 
                485                 490                 495     


Ser Ile Pro Ala Val Glu Ile Phe Met Val Lys Ile Phe Met Leu Leu 
            500                 505                 510         


Val Val Gly Ile Thr Ser Gly Met Trp Ile Trp Thr Ser Lys Thr Leu 
        515                 520                 525             


Gln Ser Trp Gln Gln Val Cys Ser Arg Arg Leu Lys Lys Lys Ser Arg 
    530                 535                 540                 


Arg Lys Pro Ala Ser Val Ile Thr Ser Gly Gly Ile Tyr Lys Lys Ala 
545                 550                 555                 560 


Gln His Pro Gln Lys Thr His His Gly Lys Tyr Glu Ile Pro Ala Gln 
                565                 570                 575     


Ser Pro Thr Cys Val 
            580     


<210>  3648
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  3648

Met Arg Leu Leu Arg Arg Arg His Met Pro Leu Arg Leu Ala Met Val 
1               5                   10                  15      


Gly Cys Ala Phe Val Leu Phe Leu Phe Leu Leu His Arg Asp Val Ser 
            20                  25                  30          


Ser Arg Glu Glu Ala Thr Glu Lys Pro Trp Leu Lys Ser Leu Val Ser 
        35                  40                  45              


Arg Lys Asp His Val Leu Asp Leu Met Leu Glu Ala Met Asn Asn Leu 
    50                  55                  60                  


Arg Asp Ser Met Pro Lys Leu Gln Ile Arg Ala Pro Glu Ala Gln Gln 
65                  70                  75                  80  


Thr Leu Phe Ser Ile Asn Gln Ser Cys Leu Pro Gly Phe Tyr Thr Pro 
                85                  90                  95      


Ala Glu Leu Lys Pro Phe Trp Glu Arg Pro Pro Gln Asp Pro Asn Ala 
            100                 105                 110         


Pro Gly Ala Asp Gly Lys Ala Phe Gln Lys Ser Lys Trp Thr Pro Leu 
        115                 120                 125             


Glu Thr Gln Glu Lys Glu Glu Gly Tyr Lys Lys His Cys Phe Asn Ala 
    130                 135                 140                 


Phe Ala Ser Asp Arg Ile Ser Leu Gln Arg Ser Leu Gly Pro Asp Thr 
145                 150                 155                 160 


Arg Pro Pro Glu Cys Val Asp Gln Lys Phe Arg Arg Cys Pro Pro Leu 
                165                 170                 175     


Ala Thr Thr Ser Val Ile Ile Val Phe His Asn Glu Ala Trp Ser Thr 
            180                 185                 190         


Leu Leu Arg Thr Val Tyr Ser Val Leu His Thr Thr Pro Ala Ile Leu 
        195                 200                 205             


Leu Lys Glu Ile Ile Leu Val Asp Asp Ala Ser Thr Glu Glu His Leu 
    210                 215                 220                 


Lys Glu Lys Leu Glu Gln Tyr Val Lys Gln Leu Gln Val Val Arg Val 
225                 230                 235                 240 


Val Arg Gln Glu Glu Arg Lys Gly Leu Ile Thr Ala Arg Leu Leu Gly 
                245                 250                 255     


Ala Ser Val Ala Gln Ala Glu Val Leu Thr Phe Leu Asp Ala His Cys 
            260                 265                 270         


Glu Cys Phe His Gly Trp Leu Glu Pro Leu Leu Ala Arg Ile Ala Glu 
        275                 280                 285             


Asp Lys Thr Val Val Val Ser Pro Asp Ile Val Thr Ile Asp Leu Asn 
    290                 295                 300                 


Thr Phe Glu Phe Ala Lys Pro Val Gln Arg Gly Arg Val His Ser Arg 
305                 310                 315                 320 


Gly Asn Phe Asp Trp Ser Leu Thr Phe Gly Trp Glu Thr Leu Pro Pro 
                325                 330                 335     


His Glu Lys Gln Arg Arg Lys Asp Glu Thr Tyr Pro Ile Lys Ser Pro 
            340                 345                 350         


Thr Phe Ala Gly Gly Leu Phe Ser Ile Ser Lys Ser Tyr Phe Glu His 
        355                 360                 365             


Ile Gly Thr Tyr Asp Asn Gln Met Glu Ile Trp Gly Gly Glu Asn Val 
    370                 375                 380                 


Glu Met Ser Phe Arg Val Trp Gln Cys Gly Gly Gln Leu Glu Ile Ile 
385                 390                 395                 400 


Pro Cys Ser Val Val Gly His Val Phe Arg Thr Lys Ser Pro His Thr 
                405                 410                 415     


Phe Pro Lys Gly Thr Ser Val Ile Ala Arg Asn Gln Val Arg Leu Ala 
            420                 425                 430         


Glu Val Trp Met Asp Ser Tyr Lys Lys Ile Phe Tyr Arg Arg Asn Leu 
        435                 440                 445             


Gln Ala Ala Lys Met Ala Gln Glu Lys Ser Phe Gly Asp Ile Ser Glu 
    450                 455                 460                 


Arg Leu Gln Leu Arg Glu Gln Leu His Cys His Asn Phe Ser Trp Tyr 
465                 470                 475                 480 


Leu His Asn Val Tyr Pro Glu Met Phe Val Pro Asp Leu Thr Pro Thr 
                485                 490                 495     


Phe Tyr Gly Ala Ile Lys Asn Leu Gly Thr Asn Gln Cys Leu Asp Val 
            500                 505                 510         


Gly Glu Asn Asn Arg Gly Gly Lys Pro Leu Ile Met Tyr Ser Cys His 
        515                 520                 525             


Gly Leu Gly Gly Asn Gln Tyr Phe Glu Tyr Thr Thr Gln Arg Asp Leu 
    530                 535                 540                 


Arg His Asn Ile Ala Lys Gln Leu Cys Leu His Val Ser Lys Gly Ala 
545                 550                 555                 560 


Leu Gly Leu Gly Ser Cys His Phe Thr Gly Lys Asn Ser Gln Val Pro 
                565                 570                 575     


Lys Asp Glu Glu Trp Glu Leu Ala Gln Asp Gln Leu Ile Arg Asn Ser 
            580                 585                 590         


Gly Ser Gly Thr Cys Leu Thr Ser Gln Asp Lys Lys Pro Ala Met Ala 
        595                 600                 605             


Pro Cys Asn Pro Ser Asp Pro His Gln Leu Trp Leu Phe Val 
    610                 615                 620         


<210>  3649
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  3649

Met Ser Glu Val Arg Leu Pro Pro Leu Arg Ala Leu Asp Asp Phe Val 
1               5                   10                  15      


Leu Gly Ser Ala Arg Leu Ala Ala Pro Asp Pro Cys Asp Pro Gln Arg 
            20                  25                  30          


Trp Cys His Arg Val Ile Asn Asn Leu Leu Tyr Tyr Gln Thr Asn Tyr 
        35                  40                  45              


Leu Leu Cys Phe Gly Ile Gly Leu Ala Leu Ala Gly Tyr Val Arg Pro 
    50                  55                  60                  


Leu His Thr Leu Leu Ser Ala Leu Val Val Ala Val Ala Leu Gly Val 
65                  70                  75                  80  


Leu Val Trp Ala Ala Glu Thr Arg Ala Ala Val Arg Arg Cys Arg Arg 
                85                  90                  95      


Ser His Pro Ala Ala Cys Leu Ala Ala Val Leu Ala Val Gly Leu Leu 
            100                 105                 110         


Val Leu Trp Val Ala Gly Gly Ala Cys Thr Phe Leu Phe Ser Ile Ala 
        115                 120                 125             


Gly Pro Val Leu Leu Ile Leu Val His Ala Ser Leu Arg Leu Arg Asn 
    130                 135                 140                 


Leu Lys Asn Lys Ile Glu Asn Lys Ile Glu Ser Ile Gly Leu Lys Arg 
145                 150                 155                 160 


Thr Pro Met Gly Leu Leu Leu Glu Ala Leu Gly Gln Glu Gln Glu Ala 
                165                 170                 175     


Gly Ser 
        


<210>  3650
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  3650

Met Ala Gly Gln Gln Phe Gln Tyr Asp Asp Ser Gly Asn Thr Phe Phe 
1               5                   10                  15      


Tyr Phe Leu Thr Ser Phe Val Gly Leu Ile Val Ile Pro Ala Thr Tyr 
            20                  25                  30          


Tyr Leu Trp Pro Arg Asp Gln Asn Ala Glu Gln Ile Arg Leu Lys Asn 
        35                  40                  45              


Ile Arg Lys Val Tyr Gly Arg Cys Met Trp Tyr Arg Leu Arg Leu Leu 
    50                  55                  60                  


Lys Pro Gln Pro Asn Ile Ile Pro Thr Val Lys Lys Ile Val Leu Leu 
65                  70                  75                  80  


Ala Gly Trp Ala Leu Phe Leu Phe Leu Ala Tyr Lys Val Ser Lys Thr 
                85                  90                  95      


Asp Arg Glu Tyr Gln Glu Tyr Asn Pro Tyr Glu Val Leu Asn Leu Asp 
            100                 105                 110         


Pro Gly Ala Thr Val Ala Glu Ile Lys Lys Gln Tyr Arg Leu Leu Ser 
        115                 120                 125             


Leu Lys Tyr His Pro Asp Lys Gly Gly Asp Glu Val Met Phe Met Arg 
    130                 135                 140                 


Ile Ala Lys Ala Tyr Ala Ala Leu Thr Asp Glu Glu Ser Arg Lys Asn 
145                 150                 155                 160 


Trp Glu Glu Phe Gly Asn Pro Asp Gly Pro Gln Ala Thr Ser Phe Gly 
                165                 170                 175     


Ile Ala Leu Pro Ala Trp Ile Val Asp Gln Lys Asn Ser Ile Leu Val 
            180                 185                 190         


Leu Leu Val Tyr Gly Leu Ala Phe Met Val Ile Leu Pro Val Val Val 
        195                 200                 205             


Gly Ser Trp Trp Tyr Arg Ser Ile Arg Tyr Ser Gly Asp Gln Ile Leu 
    210                 215                 220                 


Ile Arg Thr Thr Gln Ile Tyr Thr Tyr Phe Val Tyr Lys Thr Arg Asn 
225                 230                 235                 240 


Met Asp Met Lys Arg Leu Ile Met Val Leu Ala Gly Ala Ser Glu Phe 
                245                 250                 255     


Asp Pro Gln Tyr Asn Lys Asp Ala Thr Ser Arg Pro Thr Asp Asn Ile 
            260                 265                 270         


Leu Ile Pro Gln Leu Ile Arg Glu Ile Gly Ser Ile Asn Leu Lys Lys 
        275                 280                 285             


Asn Glu Pro Pro Leu Thr Cys Pro Tyr Ser Leu Lys Ala Arg Val Leu 
    290                 295                 300                 


Leu Leu Ser His Leu Ala Arg Met Lys Ile Pro Glu Thr Leu Glu Glu 
305                 310                 315                 320 


Asp Gln Gln Phe Met Leu Lys Lys Cys Pro Ala Leu Leu Gln Glu Met 
                325                 330                 335     


Val Asn Val Ile Cys Gln Leu Ile Val Met Ala Arg Asn Arg Glu Glu 
            340                 345                 350         


Arg Glu Phe Arg Ala Pro Thr Leu Ala Ser Leu Glu Asn Cys Met Lys 
        355                 360                 365             


Leu Ser Gln Met Ala Val Gln Gly Leu Gln Gln Phe Lys Ser Pro Leu 
    370                 375                 380                 


Leu Gln Leu Pro His Ile Glu Glu Asp Asn Leu Arg Arg Val Ser Asn 
385                 390                 395                 400 


His Lys Lys Tyr Lys Ile Lys Thr Ile Gln Asp Leu Val Ser Leu Lys 
                405                 410                 415     


Glu Ser Asp Arg His Thr Leu Leu His Phe Leu Glu Asp Glu Lys Tyr 
            420                 425                 430         


Glu Glu Val Met Ala Val Leu Gly Ser Phe Pro Tyr Val Thr Met Asp 
        435                 440                 445             


Ile Lys Ser Gln Val Leu Asp Asp Glu Asp Ser Asn Asn Ile Thr Val 
    450                 455                 460                 


Gly Ser Leu Val Thr Val Leu Val Lys Leu Thr Arg Gln Thr Met Ala 
465                 470                 475                 480 


Glu Val Phe Glu Lys Glu Gln Ser Ile Cys Ala Ala Glu Glu Gln Pro 
                485                 490                 495     


Ala Glu Asp Gly Gln Gly Glu Thr Asn Lys Asn Arg Thr Lys Gly Gly 
            500                 505                 510         


Trp Gln Gln Lys Ser Lys Gly Pro Lys Lys Thr Ala Lys Ser Lys Lys 
        515                 520                 525             


Lys Lys Pro Leu Lys Lys Lys Pro Thr Pro Val Leu Leu Pro Gln Ser 
    530                 535                 540                 


Lys Gln Gln Lys Gln Lys Gln Ala Asn Gly Val Val Gly Asn Glu Ala 
545                 550                 555                 560 


Ala Val Lys Glu Asp Glu Glu Glu Val Ser Asp Lys Gly Ser Asp Ser 
                565                 570                 575     


Glu Glu Glu Glu Thr Asn Arg Asp Ser Gln Ser Glu Lys Asp Asp Gly 
            580                 585                 590         


Ser Asp Arg Asp Ser Asp Arg Glu Gln Asp Glu Lys Gln Asn Lys Asp 
        595                 600                 605             


Asp Glu Ala Glu Trp Gln Glu Leu Gln Gln Ser Ile Gln Arg Lys Glu 
    610                 615                 620                 


Arg Ala Leu Leu Glu Thr Lys Ser Lys Ile Thr His Pro Val Tyr Ser 
625                 630                 635                 640 


Leu Tyr Phe Pro Glu Glu Lys Gln Glu Trp Trp Trp Leu Tyr Ile Ala 
                645                 650                 655     


Asp Arg Lys Glu Gln Thr Leu Ile Ser Met Pro Tyr His Val Cys Thr 
            660                 665                 670         


Leu Lys Asp Thr Glu Glu Val Glu Leu Lys Phe Pro Ala Pro Gly Lys 
        675                 680                 685             


Pro Gly Asn Tyr Gln Tyr Thr Val Phe Leu Arg Ser Asp Ser Tyr Met 
    690                 695                 700                 


Gly Leu Asp Gln Ile Lys Pro Leu Lys Leu Glu Val His Glu Ala Lys 
705                 710                 715                 720 


Pro Val Pro Glu Asn His Pro Gln Trp Asp Thr Ala Ile Glu Gly Asp 
                725                 730                 735     


Glu Asp Gln Glu Asp Ser Glu Gly Phe Glu Asp Ser Phe Glu Glu Glu 
            740                 745                 750         


Glu Glu Glu Glu Glu Asp Asp Asp 
        755                 760 


<210>  3651
<211>  485
<212>  PRT
<213>  Homo sapiens

<400>  3651

Met Arg Ser Arg Val Ala Val Arg Ala Cys His Lys Val Cys Arg Cys 
1               5                   10                  15      


Leu Leu Ser Gly Phe Gly Gly Arg Val Asp Ala Gly Gln Pro Glu Leu 
            20                  25                  30          


Leu Thr Glu Arg Ser Ser Pro Lys Gly Gly His Val Lys Ser His Ala 
        35                  40                  45              


Glu Leu Glu Gly Asn Gly Glu His Pro Glu Ala Pro Gly Ser Gly Glu 
    50                  55                  60                  


Gly Ser Glu Ala Leu Leu Glu Ile Cys Gln Arg Arg His Phe Leu Ser 
65                  70                  75                  80  


Gly Ser Lys Gln Gln Leu Ser Arg Asp Ser Leu Leu Ser Gly Cys His 
                85                  90                  95      


Pro Gly Phe Gly Pro Leu Gly Val Glu Leu Arg Lys Asn Leu Ala Ala 
            100                 105                 110         


Glu Trp Trp Thr Ser Val Val Val Phe Arg Glu Gln Val Phe Pro Val 
        115                 120                 125             


Asp Ala Leu His His Lys Pro Gly Pro Leu Leu Pro Gly Asp Ser Ala 
    130                 135                 140                 


Phe Arg Leu Val Ser Ala Glu Thr Leu Arg Glu Ile Leu Gln Asp Lys 
145                 150                 155                 160 


Glu Leu Ser Lys Glu Gln Leu Val Ala Phe Leu Glu Asn Val Leu Lys 
                165                 170                 175     


Thr Ser Gly Lys Leu Arg Glu Asn Leu Leu His Gly Ala Leu Glu His 
            180                 185                 190         


Tyr Val Asn Cys Leu Asp Leu Val Asn Lys Arg Leu Pro Tyr Gly Leu 
        195                 200                 205             


Ala Gln Ile Gly Val Cys Phe His Pro Val Phe Asp Thr Lys Gln Ile 
    210                 215                 220                 


Arg Asn Gly Val Lys Ser Ile Gly Glu Lys Thr Glu Ala Ser Leu Val 
225                 230                 235                 240 


Trp Phe Thr Pro Pro Arg Thr Ser Asn Gln Trp Leu Asp Phe Trp Leu 
                245                 250                 255     


Arg His Arg Leu Gln Trp Trp Arg Lys Phe Ala Met Ser Pro Ser Asn 
            260                 265                 270         


Phe Ser Ser Ser Asp Cys Gln Asp Glu Glu Gly Arg Lys Gly Asn Lys 
        275                 280                 285             


Leu Tyr Tyr Asn Phe Pro Trp Gly Lys Glu Leu Ile Glu Thr Leu Trp 
    290                 295                 300                 


Asn Leu Gly Asp His Glu Leu Leu His Met Tyr Pro Gly Asn Val Ser 
305                 310                 315                 320 


Lys Leu His Gly Arg Asp Gly Arg Lys Asn Val Val Pro Cys Val Leu 
                325                 330                 335     


Ser Val Asn Gly Asp Leu Asp Arg Gly Met Leu Ala Tyr Leu Tyr Asp 
            340                 345                 350         


Ser Phe Gln Leu Thr Glu Asn Ser Phe Thr Arg Lys Lys Asn Leu His 
        355                 360                 365             


Arg Lys Val Leu Lys Leu His Pro Cys Leu Ala Pro Ile Lys Val Ala 
    370                 375                 380                 


Leu Asp Val Gly Arg Gly Pro Thr Leu Glu Leu Arg Gln Val Cys Gln 
385                 390                 395                 400 


Gly Leu Phe Asn Glu Leu Leu Glu Asn Gly Ile Ser Val Trp Pro Gly 
                405                 410                 415     


Tyr Leu Glu Thr Met Gln Ser Ser Leu Glu Gln Leu Tyr Ser Lys Tyr 
            420                 425                 430         


Asp Glu Met Ser Ile Leu Phe Thr Val Leu Val Thr Glu Thr Thr Leu 
        435                 440                 445             


Glu Asn Gly Leu Ile His Leu Arg Ser Arg Asp Thr Thr Met Lys Glu 
    450                 455                 460                 


Met Met His Ile Ser Lys Leu Lys Asp Phe Leu Ile Lys Tyr Ile Ser 
465                 470                 475                 480 


Ser Ala Lys Asn Val 
                485 


<210>  3652
<211>  664
<212>  PRT
<213>  Homo sapiens

<400>  3652

Met Ala Ala Val Gly Pro Pro Gln Gln Gln Val Arg Met Ala His Gln 
1               5                   10                  15      


Gln Val Trp Ala Ala Leu Glu Val Ala Leu Arg Val Pro Cys Leu Tyr 
            20                  25                  30          


Ile Ile Asp Ala Ile Phe Asn Ser Tyr Pro Asp Ser Ser Gln Ser Arg 
        35                  40                  45              


Phe Cys Ile Val Leu Gln Ile Phe Leu Arg Leu Phe Gly Val Phe Ala 
    50                  55                  60                  


Ser Ser Ile Val Leu Ile Leu Ser Gln Arg Ser Leu Phe Lys Phe Tyr 
65                  70                  75                  80  


Thr Tyr Ser Ser Ala Phe Leu Leu Ala Ala Thr Ser Val Leu Val Asn 
                85                  90                  95      


Tyr Tyr Ala Ser Leu His Ile Asp Phe Tyr Gly Ala Tyr Asn Thr Ser 
            100                 105                 110         


Ala Phe Gly Ile Glu Leu Leu Pro Arg Lys Gly Pro Ser Leu Trp Met 
        115                 120                 125             


Ala Leu Ile Val Leu Gln Leu Thr Phe Gly Ile Gly Tyr Val Thr Leu 
    130                 135                 140                 


Leu Gln Ile His Ser Ile Tyr Ser Gln Leu Ile Ile Leu Asp Leu Leu 
145                 150                 155                 160 


Val Pro Val Ile Gly Leu Ile Thr Glu Leu Pro Leu His Ile Arg Glu 
                165                 170                 175     


Thr Leu Leu Phe Thr Ser Ser Leu Ile Leu Thr Leu Asn Thr Val Phe 
            180                 185                 190         


Val Leu Ala Val Lys Leu Lys Trp Phe Tyr Tyr Ser Thr Arg Tyr Val 
        195                 200                 205             


Tyr Leu Leu Val Arg His Met Tyr Arg Ile Tyr Gly Leu Gln Leu Leu 
    210                 215                 220                 


Met Glu Asp Thr Trp Lys Arg Ile Arg Phe Pro Asp Ile Leu Arg Val 
225                 230                 235                 240 


Phe Trp Leu Thr Arg Val Thr Ala Gln Ala Thr Val Leu Met Tyr Ile 
                245                 250                 255     


Leu Arg Met Ala Asn Glu Thr Asp Ser Phe Phe Ile Ser Trp Asp Asp 
            260                 265                 270         


Phe Trp Asp Leu Ile Cys Asn Leu Ile Ile Ser Gly Cys Asp Ser Thr 
        275                 280                 285             


Leu Thr Val Leu Gly Met Ser Ala Val Ile Ser Ser Val Ala His Tyr 
    290                 295                 300                 


Leu Gly Leu Gly Ile Leu Ala Phe Ile Gly Ser Thr Glu Glu Asp Asp 
305                 310                 315                 320 


Arg Arg Leu Gly Phe Val Ala Pro Val Leu Phe Phe Ile Leu Ala Leu 
                325                 330                 335     


Gln Thr Gly Leu Ser Gly Leu Arg Pro Glu Glu Arg Leu Ile Arg Leu 
            340                 345                 350         


Ser Arg Asn Met Cys Leu Leu Leu Thr Ala Val Leu His Phe Ile His 
        355                 360                 365             


Gly Met Thr Asp Pro Val Leu Met Ser Leu Ser Ala Ser His Val Ser 
    370                 375                 380                 


Ser Phe Arg Arg His Phe Pro Val Leu Phe Val Ser Ala Cys Leu Phe 
385                 390                 395                 400 


Ile Leu Pro Val Leu Leu Ser Tyr Val Leu Trp His His Tyr Ala Leu 
                405                 410                 415     


Asn Thr Trp Leu Phe Ala Val Thr Ala Phe Cys Val Glu Leu Cys Leu 
            420                 425                 430         


Lys Val Ile Val Ser Leu Thr Val Tyr Thr Leu Phe Met Ile Asp Gly 
        435                 440                 445             


Tyr Tyr Asn Val Leu Trp Glu Lys Leu Asp Asp Tyr Val Tyr Tyr Val 
    450                 455                 460                 


Arg Ser Thr Gly Ser Ile Ile Glu Phe Ile Phe Gly Val Val Met Phe 
465                 470                 475                 480 


Gly Asn Gly Ala Tyr Thr Met Met Phe Glu Ser Gly Ser Lys Ile Arg 
                485                 490                 495     


Ala Phe Met Met Cys Leu His Ala Tyr Phe Asn Ile Tyr Leu Gln Ala 
            500                 505                 510         


Lys Asn Gly Trp Lys Thr Phe Met Asn Arg Arg Thr Ala Val Lys Lys 
        515                 520                 525             


Ile Asn Ser Leu Pro Glu Ile Lys Gly Ser Arg Leu Gln Glu Ile Asn 
    530                 535                 540                 


Asp Val Cys Ala Ile Cys Tyr His Glu Phe Thr Thr Ser Ala Arg Ile 
545                 550                 555                 560 


Thr Pro Cys Asn His Tyr Phe His Ala Leu Cys Leu Arg Lys Trp Leu 
                565                 570                 575     


Tyr Ile Gln Asp Thr Cys Pro Met Cys His Gln Lys Val Tyr Ile Glu 
            580                 585                 590         


Asp Asp Ile Lys Asp Asn Ser Asn Val Ser Asn Asn Asn Gly Phe Ile 
        595                 600                 605             


Pro Pro Asn Glu Thr Pro Glu Glu Ala Val Arg Glu Ala Ala Ala Glu 
    610                 615                 620                 


Ser Asp Arg Glu Leu Asn Glu Asp Asp Ser Thr Asp Cys Asp Asp Asp 
625                 630                 635                 640 


Val Gln Arg Glu Arg Asn Gly Val Ile Gln His Thr Gly Ala Ala Ala 
                645                 650                 655     


Glu Glu Phe Asn Asp Asp Thr Asp 
            660                 


<210>  3653
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  3653

Met Ser Ser Asp Phe Pro His Tyr Asn Phe Arg Met Pro Asn Ile Gly 
1               5                   10                  15      


Phe Gln Asn Leu Pro Leu Asn Ile Tyr Ile Val Val Phe Gly Thr Ala 
            20                  25                  30          


Ile Phe Val Phe Ile Leu Ser Leu Leu Phe Cys Cys Tyr Leu Ile Arg 
        35                  40                  45              


Leu Arg His Gln Ala His Lys Glu Phe Tyr Ala Tyr Lys Gln Val Ile 
    50                  55                  60                  


Leu Lys Glu Lys Val Lys Glu Leu Asn Leu His Glu Leu Cys Ala Val 
65                  70                  75                  80  


Cys Leu Glu Asp Phe Lys Pro Arg Asp Glu Leu Gly Ile Cys Pro Cys 
                85                  90                  95      


Lys His Ala Phe His Arg Lys Cys Leu Ile Lys Trp Leu Glu Val Arg 
            100                 105                 110         


Lys Val Cys Pro Leu Cys Asn Met Pro Val Leu Gln Leu Ala Gln Leu 
        115                 120                 125             


His Ser Lys Gln Asp Arg Gly Pro Pro Gln Gly Pro Leu Pro Gly Ala 
    130                 135                 140                 


Glu Asn Ile Val 
145             


<210>  3654
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  3654

Met Gly His Asn Gly Ser Trp Ile Ser Pro Asn Ala Ser Glu Pro His 
1               5                   10                  15      


Asn Ala Ser Gly Ala Glu Ala Ala Gly Val Asn Arg Ser Ala Leu Gly 
            20                  25                  30          


Glu Phe Gly Glu Ala Gln Leu Tyr Arg Gln Phe Thr Thr Thr Val Gln 
        35                  40                  45              


Val Val Ile Phe Ile Gly Ser Leu Leu Gly Asn Phe Met Val Leu Trp 
    50                  55                  60                  


Ser Thr Cys Arg Thr Thr Val Phe Lys Ser Val Thr Asn Arg Phe Ile 
65                  70                  75                  80  


Lys Asn Leu Ala Cys Ser Gly Ile Cys Ala Ser Leu Val Cys Val Pro 
                85                  90                  95      


Phe Asp Ile Ile Leu Ser Thr Ser Pro His Cys Cys Trp Trp Ile Tyr 
            100                 105                 110         


Thr Met Leu Phe Cys Lys Val Val Lys Phe Leu His Lys Val Phe Cys 
        115                 120                 125             


Ser Val Thr Ile Leu Ser Phe Pro Ala Ile Ala Leu Asp Arg Tyr Tyr 
    130                 135                 140                 


Ser Val Leu Tyr Pro Leu Glu Arg Lys Ile Ser Asp Ala Lys Ser Arg 
145                 150                 155                 160 


Glu Leu Val Met Tyr Ile Trp Ala His Ala Val Val Ala Ser Val Pro 
                165                 170                 175     


Val Phe Ala Val Thr Asn Val Ala Asp Ile Tyr Ala Thr Ser Thr Cys 
            180                 185                 190         


Thr Glu Val Trp Ser Asn Ser Leu Gly His Leu Val Tyr Val Leu Val 
        195                 200                 205             


Tyr Asn Ile Thr Thr Val Ile Val Pro Val Val Val Val Phe Leu Phe 
    210                 215                 220                 


Leu Ile Leu Ile Arg Arg Ala Leu Ser Ala Ser Gln Lys Lys Lys Val 
225                 230                 235                 240 


Ile Ile Ala Ala Leu Arg Thr Pro Gln Asn Thr Ile Ser Ile Pro Tyr 
                245                 250                 255     


Ala Ser Gln Arg Glu Ala Glu Leu His Ala Thr Leu Leu Ser Met Val 
            260                 265                 270         


Met Val Phe Ile Leu Cys Ser Val Pro Tyr Ala Thr Leu Val Val Tyr 
        275                 280                 285             


Gln Thr Val Leu Asn Val Pro Asp Thr Ser Val Phe Leu Leu Leu Thr 
    290                 295                 300                 


Ala Val Trp Leu Pro Lys Val Ser Leu Leu Ala Asn Pro Val Leu Phe 
305                 310                 315                 320 


Leu Thr Val Asn Lys Ser Val Arg Lys Cys Leu Ile Gly Thr Leu Val 
                325                 330                 335     


Gln Leu His His Arg Tyr Ser Arg Arg Asn Val Val Ser Thr Gly Ser 
            340                 345                 350         


Gly Met Ala Glu Ala Ser Leu Glu Pro Ser Ile Arg Ser Gly Ser Gln 
        355                 360                 365             


Leu Leu Glu Met Phe His Ile Gly Gln Gln Gln Ile Phe Lys Pro Thr 
    370                 375                 380                 


Glu Asp Glu Glu Glu Ser Glu Ala Lys Tyr Ile Gly Ser Ala Asp Phe 
385                 390                 395                 400 


Gln Ala Lys Glu Ile Phe Ser Thr Cys Leu Glu Gly Glu Gln Gly Pro 
                405                 410                 415     


Gln Phe Ala Pro Ser Ala Pro Pro Leu Ser Thr Val Asp Ser Val Ser 
            420                 425                 430         


Gln Val Ala Pro Ala Ala Pro Val Glu Pro Glu Thr Phe Pro Asp Lys 
        435                 440                 445             


Tyr Ser Leu Gln Phe Gly Phe Gly Pro Phe Glu Leu Pro Pro Gln Trp 
    450                 455                 460                 


Leu Ser Glu Thr Arg Asn Ser Lys Lys Arg Leu Leu Pro Pro Leu Gly 
465                 470                 475                 480 


Asn Thr Pro Glu Glu Leu Ile Gln Thr Lys Val Pro Lys Val Gly Arg 
                485                 490                 495     


Val Glu Arg Lys Met Ser Arg Asn Asn Lys Val Ser Ile Phe Pro Lys 
            500                 505                 510         


Val Asp Ser 
        515 


<210>  3655
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  3655

Met Ala Cys Asn Ser Thr Ser Leu Glu Ala Tyr Thr Tyr Leu Leu Leu 
1               5                   10                  15      


Asn Thr Ser Asn Ala Ser Asp Ser Gly Ser Thr Gln Leu Pro Ala Pro 
            20                  25                  30          


Leu Arg Ile Ser Leu Ala Ile Val Met Leu Leu Met Thr Val Val Gly 
        35                  40                  45              


Phe Leu Gly Asn Thr Val Val Cys Ile Ile Val Tyr Gln Arg Pro Ala 
    50                  55                  60                  


Met Arg Ser Ala Ile Asn Leu Leu Leu Ala Thr Leu Ala Phe Ser Asp 
65                  70                  75                  80  


Ile Met Leu Ser Leu Cys Cys Met Pro Phe Thr Ala Val Thr Leu Ile 
                85                  90                  95      


Thr Val Arg Trp His Phe Gly Asp His Phe Cys Arg Leu Ser Ala Thr 
            100                 105                 110         


Leu Tyr Trp Phe Phe Val Leu Glu Gly Val Ala Ile Leu Leu Ile Ile 
        115                 120                 125             


Ser Val Asp Arg Phe Leu Ile Ile Val Gln Arg Gln Asp Lys Leu Asn 
    130                 135                 140                 


Pro Arg Arg Ala Lys Val Ile Ile Ala Val Ser Trp Val Leu Ser Phe 
145                 150                 155                 160 


Cys Ile Ala Gly Pro Ser Leu Thr Gly Trp Thr Leu Val Glu Val Pro 
                165                 170                 175     


Ala Arg Ala Pro Gln Cys Val Leu Gly Tyr Thr Glu Leu Pro Ala Asp 
            180                 185                 190         


Arg Ala Tyr Val Val Thr Leu Val Val Ala Val Phe Phe Ala Pro Phe 
        195                 200                 205             


Gly Val Met Leu Cys Ala Tyr Met Cys Ile Leu Asn Thr Val Arg Lys 
    210                 215                 220                 


Asn Ala Val Arg Val His Asn Gln Ser Asp Ser Leu Asp Leu Arg Gln 
225                 230                 235                 240 


Leu Thr Arg Ala Gly Leu Arg Arg Leu Gln Arg Gln Gln Gln Val Ser 
                245                 250                 255     


Val Asp Leu Ser Phe Lys Thr Lys Ala Phe Thr Thr Ile Leu Ile Leu 
            260                 265                 270         


Phe Val Gly Phe Ser Leu Cys Trp Leu Pro His Ser Val Tyr Ser Leu 
        275                 280                 285             


Leu Ser Val Phe Ser Gln Arg Phe Tyr Cys Gly Ser Ser Phe Tyr Ala 
    290                 295                 300                 


Thr Ser Thr Cys Val Leu Trp Leu Ser Tyr Leu Lys Ser Val Phe Asn 
305                 310                 315                 320 


Pro Ile Val Tyr Cys Trp Arg Ile Lys Lys Phe Arg Glu Ala Cys Ile 
                325                 330                 335     


Glu Leu Leu Pro Gln Thr Phe Gln Ile Leu Pro Lys Val Pro Glu Arg 
            340                 345                 350         


Ile Arg Arg Arg Ile Gln Pro Ser Thr Val Tyr Val Cys Asn Glu Asn 
        355                 360                 365             


Gln Ser Ala Val 
    370         


<210>  3656
<211>  642
<212>  PRT
<213>  Homo sapiens

<400>  3656

Met Asp Lys Leu Lys Cys Pro Ser Phe Phe Lys Cys Arg Glu Lys Glu 
1               5                   10                  15      


Lys Val Ser Ala Ser Ser Glu Asn Phe His Val Gly Glu Asn Asp Glu 
            20                  25                  30          


Asn Gln Asp Arg Gly Asn Trp Ser Lys Lys Ser Asp Tyr Leu Leu Ser 
        35                  40                  45              


Met Ile Gly Tyr Ala Val Gly Leu Gly Asn Val Trp Arg Phe Pro Tyr 
    50                  55                  60                  


Leu Thr Tyr Ser Asn Gly Gly Gly Ala Phe Leu Ile Pro Tyr Ala Ile 
65                  70                  75                  80  


Met Leu Ala Leu Ala Gly Leu Pro Leu Phe Phe Leu Glu Cys Ser Leu 
                85                  90                  95      


Gly Gln Phe Ala Ser Leu Gly Pro Val Ser Val Trp Arg Ile Leu Pro 
            100                 105                 110         


Leu Phe Gln Gly Val Gly Ile Thr Met Val Leu Ile Ser Ile Phe Val 
        115                 120                 125             


Thr Ile Tyr Tyr Asn Val Ile Ile Ala Tyr Ser Leu Tyr Tyr Met Phe 
    130                 135                 140                 


Ala Ser Phe Gln Ser Glu Leu Pro Trp Lys Asn Cys Ser Ser Trp Ser 
145                 150                 155                 160 


Asp Lys Asn Cys Ser Arg Ser Pro Ile Val Thr His Cys Asn Val Ser 
                165                 170                 175     


Thr Val Asn Lys Gly Ile Gln Glu Ile Ile Gln Met Asn Lys Ser Trp 
            180                 185                 190         


Val Asp Ile Asn Asn Phe Thr Cys Ile Asn Gly Ser Glu Ile Tyr Gln 
        195                 200                 205             


Pro Gly Gln Leu Pro Ser Glu Gln Tyr Trp Asn Lys Val Ala Leu Gln 
    210                 215                 220                 


Arg Ser Ser Gly Met Asn Glu Thr Gly Val Ile Val Trp Tyr Leu Ala 
225                 230                 235                 240 


Leu Cys Leu Leu Leu Ala Trp Leu Ile Val Gly Ala Ala Leu Phe Lys 
                245                 250                 255     


Gly Ile Lys Ser Ser Gly Lys Val Val Tyr Phe Thr Ala Leu Phe Pro 
            260                 265                 270         


Tyr Val Val Leu Leu Ile Leu Leu Val Arg Gly Ala Thr Leu Glu Gly 
        275                 280                 285             


Ala Ser Lys Gly Ile Ser Tyr Tyr Ile Gly Ala Gln Ser Asn Phe Thr 
    290                 295                 300                 


Lys Leu Lys Glu Ala Glu Val Trp Lys Asp Ala Ala Thr Gln Ile Phe 
305                 310                 315                 320 


Tyr Ser Leu Ser Val Ala Trp Gly Gly Leu Val Ala Leu Ser Ser Tyr 
                325                 330                 335     


Asn Lys Phe Lys Asn Asn Cys Phe Ser Asp Ala Ile Val Val Cys Leu 
            340                 345                 350         


Thr Asn Cys Leu Thr Ser Val Phe Ala Gly Phe Ala Ile Phe Ser Ile 
        355                 360                 365             


Leu Gly His Met Ala His Ile Ser Gly Lys Glu Val Ser Gln Val Val 
    370                 375                 380                 


Lys Ser Gly Phe Asp Leu Ala Phe Ile Ala Tyr Pro Glu Ala Leu Ala 
385                 390                 395                 400 


Gln Leu Pro Gly Gly Pro Phe Trp Ser Ile Leu Phe Phe Phe Met Leu 
                405                 410                 415     


Leu Thr Leu Gly Leu Asp Ser Gln Phe Ala Ser Ile Glu Thr Ile Thr 
            420                 425                 430         


Thr Thr Ile Gln Asp Leu Phe Pro Lys Val Met Lys Lys Met Arg Val 
        435                 440                 445             


Pro Ile Thr Leu Gly Cys Cys Leu Val Leu Phe Leu Leu Gly Leu Val 
    450                 455                 460                 


Cys Val Thr Gln Ala Gly Ile Tyr Trp Val His Leu Ile Asp His Phe 
465                 470                 475                 480 


Cys Ala Gly Trp Gly Ile Leu Ile Ala Ala Ile Leu Glu Leu Val Gly 
                485                 490                 495     


Ile Ile Trp Ile Tyr Gly Gly Asn Arg Phe Ile Glu Asp Thr Glu Met 
            500                 505                 510         


Met Ile Gly Ala Lys Arg Trp Ile Phe Trp Leu Trp Trp Arg Ala Cys 
        515                 520                 525             


Trp Phe Val Ile Thr Pro Ile Leu Leu Ile Ala Ile Phe Ile Trp Ser 
    530                 535                 540                 


Leu Val Gln Phe His Arg Pro Asn Tyr Gly Ala Ile Pro Tyr Pro Asp 
545                 550                 555                 560 


Trp Gly Val Ala Leu Gly Trp Cys Met Ile Val Phe Cys Ile Ile Trp 
                565                 570                 575     


Ile Pro Ile Met Ala Ile Ile Lys Ile Ile Gln Ala Lys Gly Asn Ile 
            580                 585                 590         


Phe Gln Arg Leu Ile Ser Cys Cys Arg Pro Ala Ser Asn Trp Gly Pro 
        595                 600                 605             


Tyr Leu Glu Gln His Arg Gly Glu Arg Tyr Lys Asp Met Val Asp Pro 
    610                 615                 620                 


Lys Lys Glu Ala Asp His Glu Ile Pro Thr Val Ser Gly Ser Arg Lys 
625                 630                 635                 640 


Pro Glu 
        


<210>  3657
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  3657

Met Glu Arg Ala Pro Pro Asp Gly Pro Leu Asn Ala Ser Gly Ala Leu 
1               5                   10                  15      


Ala Gly Glu Ala Ala Ala Ala Gly Gly Ala Arg Gly Phe Ser Ala Ala 
            20                  25                  30          


Trp Thr Ala Val Leu Ala Ala Leu Met Ala Leu Leu Ile Val Ala Thr 
        35                  40                  45              


Val Leu Gly Asn Ala Leu Val Met Leu Ala Phe Val Ala Asp Ser Ser 
    50                  55                  60                  


Leu Arg Thr Gln Asn Asn Phe Phe Leu Leu Asn Leu Ala Ile Ser Asp 
65                  70                  75                  80  


Phe Leu Val Gly Ala Phe Cys Ile Pro Leu Tyr Val Pro Tyr Val Leu 
                85                  90                  95      


Thr Gly Arg Trp Thr Phe Gly Arg Gly Leu Cys Lys Leu Trp Leu Val 
            100                 105                 110         


Val Asp Tyr Leu Leu Cys Thr Ser Ser Ala Phe Asn Ile Val Leu Ile 
        115                 120                 125             


Ser Tyr Asp Arg Phe Leu Ser Val Thr Arg Ala Val Ser Tyr Arg Ala 
    130                 135                 140                 


Gln Gln Gly Asp Thr Arg Arg Ala Val Arg Lys Met Leu Leu Val Trp 
145                 150                 155                 160 


Val Leu Ala Phe Leu Leu Tyr Gly Pro Ala Ile Leu Ser Trp Glu Tyr 
                165                 170                 175     


Leu Ser Gly Gly Ser Ser Ile Pro Glu Gly His Cys Tyr Ala Glu Phe 
            180                 185                 190         


Phe Tyr Asn Trp Tyr Phe Leu Ile Thr Ala Ser Thr Leu Glu Phe Phe 
        195                 200                 205             


Thr Pro Phe Leu Ser Val Thr Phe Phe Asn Leu Ser Ile Tyr Leu Asn 
    210                 215                 220                 


Ile Gln Arg Arg Thr Arg Leu Arg Leu Asp Gly Ala Arg Glu Ala Ala 
225                 230                 235                 240 


Gly Pro Glu Pro Pro Pro Glu Ala Gln Pro Ser Pro Pro Pro Pro Pro 
                245                 250                 255     


Gly Cys Trp Gly Cys Trp Gln Lys Gly His Gly Glu Ala Met Pro Leu 
            260                 265                 270         


His Arg Tyr Gly Val Gly Glu Ala Ala Val Gly Ala Glu Ala Gly Glu 
        275                 280                 285             


Ala Thr Leu Gly Gly Gly Gly Gly Gly Gly Ser Val Ala Ser Pro Thr 
    290                 295                 300                 


Ser Ser Ser Gly Ser Ser Ser Arg Gly Thr Glu Arg Pro Arg Ser Leu 
305                 310                 315                 320 


Lys Arg Gly Ser Lys Pro Ser Ala Ser Ser Ala Ser Leu Glu Lys Arg 
                325                 330                 335     


Met Lys Met Val Ser Gln Ser Phe Thr Gln Arg Phe Arg Leu Ser Arg 
            340                 345                 350         


Asp Arg Lys Val Ala Lys Ser Leu Ala Val Ile Val Ser Ile Phe Gly 
        355                 360                 365             


Leu Cys Trp Ala Pro Tyr Thr Leu Leu Met Ile Ile Arg Ala Ala Cys 
    370                 375                 380                 


His Gly His Cys Val Pro Asp Tyr Trp Tyr Glu Thr Ser Phe Trp Leu 
385                 390                 395                 400 


Leu Trp Ala Asn Ser Ala Val Asn Pro Val Leu Tyr Pro Leu Cys His 
                405                 410                 415     


His Ser Phe Arg Arg Ala Phe Thr Lys Leu Leu Cys Pro Gln Lys Leu 
            420                 425                 430         


Lys Ile Gln Pro His Ser Ser Leu Glu His Cys Trp Lys 
        435                 440                 445 


<210>  3658
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  3658

Met Ala Pro Ala Leu Leu Leu Ile Pro Ala Ala Leu Ala Ser Phe Ile 
1               5                   10                  15      


Leu Ala Phe Gly Thr Gly Val Glu Phe Val Arg Phe Thr Ser Leu Arg 
            20                  25                  30          


Pro Leu Leu Gly Gly Ile Pro Glu Ser Gly Gly Pro Asp Ala Arg Gln 
        35                  40                  45              


Gly Trp Leu Ala Ala Leu Gln Asp Arg Ser Ile Leu Ala Pro Leu Ala 
    50                  55                  60                  


Trp Asp Leu Gly Leu Leu Leu Leu Phe Val Gly Gln His Ser Leu Met 
65                  70                  75                  80  


Ala Ala Glu Arg Val Lys Ala Trp Thr Ser Arg Tyr Phe Gly Val Leu 
                85                  90                  95      


Gln Arg Ser Leu Tyr Val Ala Cys Thr Ala Leu Ala Leu Gln Leu Val 
            100                 105                 110         


Met Arg Tyr Trp Glu Pro Ile Pro Lys Gly Pro Val Leu Trp Glu Ala 
        115                 120                 125             


Arg Ala Glu Pro Trp Ala Thr Trp Val Pro Leu Leu Cys Phe Val Leu 
    130                 135                 140                 


His Val Ile Ser Trp Leu Leu Ile Phe Ser Ile Leu Leu Val Phe Asp 
145                 150                 155                 160 


Tyr Ala Glu Leu Met Gly Leu Lys Gln Val Tyr Tyr His Val Leu Gly 
                165                 170                 175     


Leu Gly Glu Pro Leu Ala Leu Lys Ser Pro Arg Ala Leu Arg Leu Phe 
            180                 185                 190         


Ser His Leu Arg His Pro Val Cys Val Glu Leu Leu Thr Val Leu Trp 
        195                 200                 205             


Val Val Pro Thr Leu Gly Thr Asp Arg Leu Leu Leu Ala Phe Leu Leu 
    210                 215                 220                 


Thr Leu Tyr Leu Gly Leu Ala His Gly Leu Asp Gln Gln Asp Leu Arg 
225                 230                 235                 240 


Tyr Leu Arg Ala Gln Leu Gln Arg Lys Leu His Leu Leu Ser Arg Pro 
                245                 250                 255     


Gln Asp Gly Glu Ala Glu 
            260         


<210>  3659
<211>  593
<212>  PRT
<213>  Homo sapiens

<400>  3659

Met Glu Thr Pro Pro Leu Pro Pro Ala Cys Thr Lys Gln Gly His Gln 
1               5                   10                  15      


Lys Pro Leu Asp Ser Lys Asp Asp Asn Thr Glu Lys His Cys Pro Val 
            20                  25                  30          


Thr Val Asn Pro Trp His Met Lys Lys Ala Phe Lys Val Met Asn Glu 
        35                  40                  45              


Leu Arg Ser Gln Asn Leu Leu Cys Asp Val Thr Ile Val Ala Glu Asp 
    50                  55                  60                  


Met Glu Ile Ser Ala His Arg Val Val Leu Ala Ala Cys Ser Pro Tyr 
65                  70                  75                  80  


Phe His Ala Met Phe Thr Gly Glu Met Ser Glu Ser Arg Ala Lys Arg 
                85                  90                  95      


Val Arg Ile Lys Glu Val Asp Gly Trp Thr Leu Arg Met Leu Ile Asp 
            100                 105                 110         


Tyr Val Tyr Thr Ala Glu Ile Gln Val Thr Glu Glu Asn Val Gln Val 
        115                 120                 125             


Leu Leu Pro Ala Ala Gly Leu Leu Gln Leu Gln Asp Val Lys Lys Thr 
    130                 135                 140                 


Cys Cys Glu Phe Leu Glu Ser Gln Leu His Pro Val Asn Cys Leu Gly 
145                 150                 155                 160 


Ile Arg Ala Phe Ala Asp Met His Ala Cys Thr Asp Leu Leu Asn Lys 
                165                 170                 175     


Ala Asn Thr Tyr Ala Glu Gln His Phe Ala Asp Val Val Leu Ser Glu 
            180                 185                 190         


Glu Phe Leu Asn Leu Gly Ile Glu Gln Val Cys Ser Leu Ile Ser Ser 
        195                 200                 205             


Asp Lys Leu Thr Ile Ser Ser Glu Glu Lys Val Phe Glu Ala Val Ile 
    210                 215                 220                 


Ala Trp Val Asn His Asp Lys Asp Val Arg Gln Glu Phe Met Ala Arg 
225                 230                 235                 240 


Leu Met Glu His Val Arg Leu Pro Leu Leu Pro Arg Glu Tyr Leu Val 
                245                 250                 255     


Gln Arg Val Glu Glu Glu Ala Leu Val Lys Asn Ser Ser Ala Cys Lys 
            260                 265                 270         


Asp Tyr Leu Ile Glu Ala Met Lys Tyr His Leu Leu Pro Thr Glu Gln 
        275                 280                 285             


Arg Ile Leu Met Lys Ser Val Arg Thr Arg Leu Arg Thr Pro Met Asn 
    290                 295                 300                 


Leu Pro Lys Leu Met Val Val Val Gly Gly Gln Ala Pro Lys Ala Ile 
305                 310                 315                 320 


Arg Ser Val Glu Cys Tyr Asp Phe Lys Glu Glu Arg Trp His Gln Val 
                325                 330                 335     


Ala Glu Leu Pro Ser Arg Arg Cys Arg Ala Gly Met Val Tyr Met Ala 
            340                 345                 350         


Gly Leu Val Phe Ala Val Gly Gly Phe Asn Gly Ser Leu Arg Val Arg 
        355                 360                 365             


Thr Val Asp Ser Tyr Asp Pro Val Lys Asp Gln Trp Thr Ser Val Ala 
    370                 375                 380                 


Asn Met Arg Asp Arg Arg Ser Thr Leu Gly Ala Ala Val Leu Asn Gly 
385                 390                 395                 400 


Leu Leu Tyr Ala Val Gly Gly Phe Asp Gly Ser Thr Gly Leu Ser Ser 
                405                 410                 415     


Val Glu Ala Tyr Asn Ile Lys Ser Asn Glu Trp Phe His Val Ala Pro 
            420                 425                 430         


Met Asn Thr Arg Arg Ser Ser Val Gly Val Gly Val Val Gly Gly Leu 
        435                 440                 445             


Leu Tyr Ala Val Gly Gly Tyr Asp Gly Ala Ser Arg Gln Cys Leu Ser 
    450                 455                 460                 


Thr Val Glu Cys Tyr Asn Ala Thr Thr Asn Glu Trp Thr Tyr Ile Ala 
465                 470                 475                 480 


Glu Met Ser Thr Arg Arg Ser Gly Ala Gly Val Gly Val Leu Asn Asn 
                485                 490                 495     


Leu Leu Tyr Ala Val Gly Gly His Asp Gly Pro Leu Val Arg Lys Ser 
            500                 505                 510         


Val Glu Val Tyr Asp Pro Thr Thr Asn Ala Trp Arg Gln Val Ala Asp 
        515                 520                 525             


Met Asn Met Cys Arg Arg Asn Ala Gly Val Cys Ala Val Asn Gly Leu 
    530                 535                 540                 


Leu Tyr Val Val Gly Gly Asp Asp Gly Ser Cys Asn Leu Ala Ser Val 
545                 550                 555                 560 


Glu Tyr Tyr Asn Pro Thr Thr Asp Lys Trp Thr Val Val Ser Ser Cys 
                565                 570                 575     


Met Ser Thr Gly Arg Ser Tyr Ala Gly Val Thr Val Ile Asp Lys Pro 
            580                 585                 590         


Leu 
    


<210>  3660
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  3660

Met Ser Leu Leu Ser Leu Ser Trp Leu Gly Leu Arg Pro Val Ala Ala 
1               5                   10                  15      


Ser Pro Trp Leu Leu Leu Leu Val Val Gly Ala Ser Trp Leu Leu Ala 
            20                  25                  30          


Arg Ile Leu Ala Trp Thr Tyr Ala Phe Tyr His Asn Gly Arg Arg Leu 
        35                  40                  45              


Arg Cys Phe Pro Gln Pro Arg Lys Gln Asn Trp Phe Leu Gly His Leu 
    50                  55                  60                  


Gly Leu Val Thr Pro Thr Glu Glu Gly Leu Arg Val Leu Thr Gln Leu 
65                  70                  75                  80  


Val Ala Thr Tyr Pro Gln Gly Phe Val Arg Trp Leu Gly Pro Ile Thr 
                85                  90                  95      


Pro Ile Ile Asn Leu Cys His Pro Asp Ile Val Arg Ser Val Ile Asn 
            100                 105                 110         


Thr Ser Asp Ala Ile Thr Asp Lys Asp Ile Val Phe Tyr Lys Thr Leu 
        115                 120                 125             


Lys Pro Trp Leu Gly Asp Gly Leu Leu Leu Ser Val Gly Asp Lys Trp 
    130                 135                 140                 


Arg His His Arg Arg Leu Leu Thr Pro Ala Phe His Phe Asn Ile Leu 
145                 150                 155                 160 


Lys Pro Tyr Ile Lys Ile Phe Ser Lys Ser Ala Asn Ile Met His Ala 
                165                 170                 175     


Lys Trp Gln Arg Leu Ala Met Glu Gly Ser Thr Cys Leu Asp Val Phe 
            180                 185                 190         


Glu His Ile Ser Leu Met Thr Leu Asp Ser Leu Gln Lys Cys Ile Phe 
        195                 200                 205             


Ser Phe Asp Ser Asn Cys Gln Glu Lys Pro Ser Glu Tyr Ile Thr Ala 
    210                 215                 220                 


Ile Met Glu Leu Ser Ala Leu Val Val Lys Arg Asn Asn Gln Phe Phe 
225                 230                 235                 240 


Arg Tyr Lys Asp Phe Leu Tyr Phe Leu Thr Pro Cys Gly Arg Arg Phe 
                245                 250                 255     


His Arg Ala Cys Arg Leu Val His Asp Phe Thr Asp Ala Val Ile Gln 
            260                 265                 270         


Glu Arg Arg Arg Thr Leu Thr Ser Gln Gly Val Asp Asp Phe Leu Gln 
        275                 280                 285             


Ala Lys Ala Lys Ser Lys Thr Leu Asp Phe Ile Asp Val Leu Leu Leu 
    290                 295                 300                 


Ser Glu Asp Lys Asn Gly Lys Glu Leu Ser Asp Glu Asp Ile Arg Ala 
305                 310                 315                 320 


Glu Ala Asp Thr Phe Met Phe Gly Gly His Asp Thr Thr Ala Ser Gly 
                325                 330                 335     


Leu Ser Trp Val Leu Tyr Asn Leu Ala Arg His Pro Glu Tyr Gln Glu 
            340                 345                 350         


Arg Cys Arg Gln Glu Val Gln Glu Leu Leu Lys Asp Arg Glu Pro Lys 
        355                 360                 365             


Glu Ile Glu Trp Asp Asp Leu Ala Gln Leu Pro Phe Leu Thr Met Cys 
    370                 375                 380                 


Leu Lys Glu Ser Leu Arg Leu His Pro Pro Ile Pro Thr Phe Ala Arg 
385                 390                 395                 400 


Gly Cys Thr Gln Asp Val Val Leu Pro Asp Ser Arg Val Ile Pro Lys 
                405                 410                 415     


Gly Asn Val Cys Asn Ile Asn Ile Phe Ala Ile His His Asn Pro Ser 
            420                 425                 430         


Val Trp Pro Asp Pro Glu Val Tyr Asp Pro Phe Arg Phe Asp Pro Glu 
        435                 440                 445             


Asn Ala Gln Lys Arg Ser Pro Met Ala Phe Ile Pro Phe Ser Ala Gly 
    450                 455                 460                 


Pro Arg Asn Cys Ile Gly Gln Lys Phe Ala Met Ala Glu Met Lys Val 
465                 470                 475                 480 


Val Leu Ala Leu Thr Leu Leu Arg Phe Arg Ile Leu Pro Asp His Arg 
                485                 490                 495     


Glu Pro Arg Arg Thr Pro Glu Ile Val Leu Arg Ala Glu Asp Gly Leu 
            500                 505                 510         


Trp Leu Arg Val Glu Pro Leu Gly 
        515                 520 


<210>  3661
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  3661

Met Phe Pro Ser Arg Arg Lys Ala Ala Gln Leu Pro Trp Glu Asp Gly 
1               5                   10                  15      


Arg Ser Gly Leu Leu Ser Gly Gly Leu Pro Arg Lys Cys Ser Val Phe 
            20                  25                  30          


His Leu Phe Val Ala Cys Leu Ser Leu Gly Phe Phe Ser Leu Leu Trp 
        35                  40                  45              


Leu Gln Leu Ser Cys Ser Gly Asp Val Ala Arg Ala Val Arg Gly Gln 
    50                  55                  60                  


Gly Gln Glu Thr Ser Gly Pro Pro Arg Ala Cys Pro Pro Glu Pro Pro 
65                  70                  75                  80  


Pro Glu His Trp Glu Glu Asp Ala Ser Trp Gly Pro His Arg Leu Ala 
                85                  90                  95      


Val Leu Val Pro Phe Arg Glu Arg Phe Glu Glu Leu Leu Val Phe Val 
            100                 105                 110         


Pro His Met Arg Arg Phe Leu Ser Arg Lys Lys Ile Arg His His Ile 
        115                 120                 125             


Tyr Val Leu Asn Gln Val Asp His Phe Arg Phe Asn Arg Ala Ala Leu 
    130                 135                 140                 


Ile Asn Val Gly Phe Leu Glu Ser Ser Asn Ser Thr Asp Tyr Ile Ala 
145                 150                 155                 160 


Met His Asp Val Asp Leu Leu Pro Leu Asn Glu Glu Leu Asp Tyr Gly 
                165                 170                 175     


Phe Pro Glu Ala Gly Pro Phe His Val Ala Ser Pro Glu Leu His Pro 
            180                 185                 190         


Leu Tyr His Tyr Lys Thr Tyr Val Gly Gly Ile Leu Leu Leu Ser Lys 
        195                 200                 205             


Gln His Tyr Arg Leu Cys Asn Gly Met Ser Asn Arg Phe Trp Gly Trp 
    210                 215                 220                 


Gly Arg Glu Asp Asp Glu Phe Tyr Arg Arg Ile Lys Gly Ala Gly Leu 
225                 230                 235                 240 


Gln Leu Phe Arg Pro Ser Gly Ile Thr Thr Gly Tyr Lys Thr Phe Arg 
                245                 250                 255     


His Leu His Asp Pro Ala Trp Arg Lys Arg Asp Gln Lys Arg Ile Ala 
            260                 265                 270         


Ala Gln Lys Gln Glu Gln Phe Lys Val Asp Arg Glu Gly Gly Leu Asn 
        275                 280                 285             


Thr Val Lys Tyr His Val Ala Ser Arg Thr Ala Leu Ser Val Gly Gly 
    290                 295                 300                 


Ala Pro Cys Thr Val Leu Asn Ile Met Leu Asp Cys Asp Lys Thr Ala 
305                 310                 315                 320 


Thr Pro Trp Cys Thr Phe Ser 
                325         


<210>  3662
<211>  709
<212>  PRT
<213>  Homo sapiens

<400>  3662

Met Gly Pro Arg Ile Gly Pro Ala Gly Glu Val Pro Gln Val Pro Asp 
1               5                   10                  15      


Lys Glu Thr Lys Ala Thr Met Gly Thr Glu Asn Thr Pro Gly Gly Lys 
            20                  25                  30          


Ala Ser Pro Asp Pro Gln Asp Val Arg Pro Ser Val Phe His Asn Ile 
        35                  40                  45              


Lys Leu Phe Val Leu Cys His Ser Leu Leu Gln Leu Ala Gln Leu Met 
    50                  55                  60                  


Ile Ser Gly Tyr Leu Lys Ser Ser Ile Ser Thr Val Glu Lys Arg Phe 
65                  70                  75                  80  


Gly Leu Ser Ser Gln Thr Ser Gly Leu Leu Ala Ser Phe Asn Glu Val 
                85                  90                  95      


Gly Asn Thr Ala Leu Ile Val Phe Val Ser Tyr Phe Gly Ser Arg Val 
            100                 105                 110         


His Arg Pro Arg Met Ile Gly Tyr Gly Ala Ile Leu Val Ala Leu Ala 
        115                 120                 125             


Gly Leu Leu Met Thr Leu Pro His Phe Ile Ser Glu Pro Tyr Arg Tyr 
    130                 135                 140                 


Asp Asn Thr Ser Pro Glu Asp Met Pro Gln Asp Phe Lys Ala Ser Leu 
145                 150                 155                 160 


Cys Leu Pro Thr Thr Ser Ala Pro Ala Ser Ala Pro Ser Asn Gly Asn 
                165                 170                 175     


Cys Ser Ser Tyr Thr Glu Thr Gln His Leu Ser Val Val Gly Ile Met 
            180                 185                 190         


Phe Val Ala Gln Thr Leu Leu Gly Val Gly Gly Val Pro Ile Gln Pro 
        195                 200                 205             


Phe Gly Ile Ser Tyr Ile Asp Asp Phe Ala His Asn Ser Asn Ser Pro 
    210                 215                 220                 


Leu Tyr Leu Gly Ile Leu Phe Ala Val Thr Met Met Gly Pro Gly Leu 
225                 230                 235                 240 


Ala Phe Gly Leu Gly Ser Leu Met Leu Arg Leu Tyr Val Asp Ile Asn 
                245                 250                 255     


Gln Met Pro Glu Gly Gly Ile Ser Leu Thr Ile Lys Asp Pro Arg Trp 
            260                 265                 270         


Val Gly Ala Trp Trp Leu Gly Phe Leu Ile Ala Ala Gly Ala Val Ala 
        275                 280                 285             


Leu Ala Ala Ile Pro Tyr Phe Phe Phe Pro Lys Glu Met Pro Lys Glu 
    290                 295                 300                 


Lys Arg Glu Leu Gln Phe Arg Arg Lys Val Leu Ala Val Thr Asp Ser 
305                 310                 315                 320 


Pro Ala Arg Lys Gly Lys Asp Ser Pro Ser Lys Gln Ser Pro Gly Glu 
                325                 330                 335     


Ser Thr Lys Lys Gln Asp Gly Leu Val Gln Ile Ala Pro Asn Leu Thr 
            340                 345                 350         


Val Ile Gln Phe Ile Lys Val Phe Pro Arg Val Leu Leu Gln Thr Leu 
        355                 360                 365             


Arg His Pro Ile Phe Leu Leu Val Val Leu Ser Gln Val Cys Leu Ser 
    370                 375                 380                 


Ser Met Ala Ala Gly Met Ala Thr Phe Leu Pro Lys Phe Leu Glu Arg 
385                 390                 395                 400 


Gln Phe Ser Ile Thr Ala Ser Tyr Ala Asn Leu Leu Ile Gly Cys Leu 
                405                 410                 415     


Ser Phe Pro Ser Val Ile Val Gly Ile Val Val Gly Gly Val Leu Val 
            420                 425                 430         


Lys Arg Leu His Leu Gly Pro Val Gly Cys Gly Ala Leu Cys Leu Leu 
        435                 440                 445             


Gly Met Leu Leu Cys Leu Phe Phe Ser Leu Pro Leu Phe Phe Ile Gly 
    450                 455                 460                 


Cys Ser Ser His Gln Ile Ala Gly Ile Thr His Gln Thr Ser Ala His 
465                 470                 475                 480 


Pro Gly Leu Glu Leu Ser Pro Ser Cys Met Glu Ala Cys Ser Cys Pro 
                485                 490                 495     


Leu Asp Gly Phe Asn Pro Val Cys Asp Pro Ser Thr Arg Val Glu Tyr 
            500                 505                 510         


Ile Thr Pro Cys His Ala Gly Cys Ser Ser Trp Val Val Gln Asp Ala 
        515                 520                 525             


Leu Asp Asn Ser Gln Val Phe Tyr Thr Asn Cys Ser Cys Val Val Glu 
    530                 535                 540                 


Gly Asn Pro Val Leu Ala Gly Ser Cys Asp Ser Thr Cys Ser His Leu 
545                 550                 555                 560 


Val Val Pro Phe Leu Leu Leu Val Ser Leu Gly Ser Ala Leu Ala Cys 
                565                 570                 575     


Leu Thr His Thr Pro Ser Phe Met Leu Ile Leu Arg Gly Val Lys Lys 
            580                 585                 590         


Glu Asp Lys Thr Leu Ala Val Gly Ile Gln Phe Met Phe Leu Arg Ile 
        595                 600                 605             


Leu Ala Trp Met Pro Ser Pro Val Ile His Gly Ser Ala Ile Asp Thr 
    610                 615                 620                 


Thr Cys Val His Trp Ala Leu Ser Cys Gly Arg Arg Ala Val Cys Arg 
625                 630                 635                 640 


Tyr Tyr Asn Asn Asp Leu Leu Arg Asn Arg Phe Ile Gly Leu Gln Phe 
                645                 650                 655     


Phe Phe Lys Thr Gly Ser Val Ile Cys Phe Ala Leu Val Leu Ala Val 
            660                 665                 670         


Leu Arg Gln Gln Asp Lys Glu Ala Arg Thr Lys Glu Ser Arg Ser Ser 
        675                 680                 685             


Pro Ala Val Glu Gln Gln Leu Leu Val Ser Gly Pro Gly Lys Lys Pro 
    690                 695                 700                 


Glu Asp Ser Arg Val 
705                 


<210>  3663
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  3663

Met Trp Leu Pro Trp Ala Leu Leu Leu Leu Trp Val Pro Gly Cys Phe 
1               5                   10                  15      


Ala Leu Ser Lys Cys Arg Thr Val Ala Gly Pro Val Gly Gly Ser Leu 
            20                  25                  30          


Ser Val Gln Cys Pro Tyr Glu Lys Glu His Arg Thr Leu Asn Lys Tyr 
        35                  40                  45              


Trp Cys Arg Pro Pro Gln Ile Phe Leu Cys Asp Lys Ile Val Glu Thr 
    50                  55                  60                  


Lys Gly Ser Ala Gly Lys Arg Asn Gly Arg Val Ser Ile Arg Asp Ser 
65                  70                  75                  80  


Pro Ala Asn Leu Ser Phe Thr Val Thr Leu Glu Asn Leu Thr Glu Glu 
                85                  90                  95      


Asp Ala Gly Thr Tyr Trp Cys Gly Val Asp Thr Pro Trp Leu Arg Asp 
            100                 105                 110         


Phe His Asp Pro Val Val Glu Val Glu Val Ser Val Phe Pro Ala Ser 
        115                 120                 125             


Thr Ser Met Thr Pro Ala Ser Ile Thr Ala Ala Lys Thr Ser Thr Ile 
    130                 135                 140                 


Thr Thr Ala Phe Pro Pro Val Ser Ser Thr Thr Leu Phe Ala Val Gly 
145                 150                 155                 160 


Ala Thr His Ser Ala Ser Ile Gln Glu Glu Thr Glu Glu Val Val Asn 
                165                 170                 175     


Ser Gln Leu Pro Leu Leu Leu Ser Leu Leu Ala Leu Leu Leu Leu Leu 
            180                 185                 190         


Leu Val Gly Ala Ser Leu Leu Ala Trp Arg Met Phe Gln Lys Trp Ile 
        195                 200                 205             


Lys Ala Gly Asp His Ser Glu Leu Ser Gln Asn Pro Lys Gln Ala Ala 
    210                 215                 220                 


Thr Gln Ser Glu Leu His Tyr Ala Asn Leu Glu Leu Leu Met Trp Pro 
225                 230                 235                 240 


Leu Gln Glu Lys Pro Ala Pro Pro Arg Glu Val Glu Val Glu Tyr Ser 
                245                 250                 255     


Thr Val Ala Ser Pro Arg Glu Glu Leu His Tyr Ala Ser Val Val Phe 
            260                 265                 270         


Asp Ser Asn Thr Asn Arg Ile Ala Ala Gln Arg Pro Arg Glu Glu Glu 
        275                 280                 285             


Pro Asp Ser Asp Tyr Ser Val Ile Arg Lys Thr 
    290                 295                 


<210>  3664
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  3664

Met Ser Val Lys Pro Ser Trp Gly Pro Gly Pro Ser Glu Gly Val Thr 
1               5                   10                  15      


Ala Val Pro Thr Ser Asp Leu Gly Glu Ile His Asn Trp Thr Glu Leu 
            20                  25                  30          


Leu Asp Leu Phe Asn His Thr Leu Ser Glu Cys His Val Glu Leu Ser 
        35                  40                  45              


Gln Ser Thr Lys Arg Val Val Leu Phe Ala Leu Tyr Leu Ala Met Phe 
    50                  55                  60                  


Val Val Gly Leu Val Glu Asn Leu Leu Val Ile Cys Val Asn Trp Arg 
65                  70                  75                  80  


Gly Ser Gly Arg Ala Gly Leu Met Asn Leu Tyr Ile Leu Asn Met Ala 
                85                  90                  95      


Ile Ala Asp Leu Gly Ile Val Leu Ser Leu Pro Val Trp Met Leu Glu 
            100                 105                 110         


Val Thr Leu Asp Tyr Thr Trp Leu Trp Gly Ser Phe Ser Cys Arg Phe 
        115                 120                 125             


Thr His Tyr Phe Tyr Phe Val Asn Met Tyr Ser Ser Ile Phe Phe Leu 
    130                 135                 140                 


Val Cys Leu Ser Val Asp Arg Tyr Val Thr Leu Thr Ser Ala Ser Pro 
145                 150                 155                 160 


Ser Trp Gln Arg Tyr Gln His Arg Val Arg Arg Ala Met Cys Ala Gly 
                165                 170                 175     


Ile Trp Val Leu Ser Ala Ile Ile Pro Leu Pro Glu Val Val His Ile 
            180                 185                 190         


Gln Leu Val Glu Gly Pro Glu Pro Met Cys Leu Phe Met Ala Pro Phe 
        195                 200                 205             


Glu Thr Tyr Ser Thr Trp Ala Leu Ala Val Ala Leu Ser Thr Thr Ile 
    210                 215                 220                 


Leu Gly Phe Leu Leu Pro Phe Pro Leu Ile Thr Val Phe Asn Val Leu 
225                 230                 235                 240 


Thr Ala Cys Arg Leu Arg Gln Pro Gly Gln Pro Lys Ser Arg Arg His 
                245                 250                 255     


Cys Leu Leu Leu Cys Ala Tyr Val Ala Val Phe Val Met Cys Trp Leu 
            260                 265                 270         


Pro Tyr His Val Thr Leu Leu Leu Leu Thr Leu His Gly Thr His Ile 
        275                 280                 285             


Ser Leu His Cys His Leu Val His Leu Leu Tyr Phe Phe Tyr Asp Val 
    290                 295                 300                 


Ile Asp Cys Phe Ser Met Leu His Cys Val Ile Asn Pro Ile Leu Tyr 
305                 310                 315                 320 


Asn Phe Leu Ser Pro His Phe Arg Gly Arg Leu Leu Asn Ala Val Val 
                325                 330                 335     


His Tyr Leu Pro Lys Asp Gln Thr Lys Ala Gly Thr Cys Ala Ser Ser 
            340                 345                 350         


Ser Ser Cys Ser Thr Gln His Ser Ile Ile Ile Thr Lys Gly Asp Ser 
        355                 360                 365             


Gln Pro Ala Ala Ala Ala Pro His Pro Glu Pro Ser Leu Ser Phe Gln 
    370                 375                 380                 


Ala His His Leu Leu Pro Asn Thr Ser Pro Ile Ser Pro Thr Gln Pro 
385                 390                 395                 400 


Leu Thr Pro Ser 
                


<210>  3665
<211>  805
<212>  PRT
<213>  Homo sapiens

<400>  3665

Met Ala Gln Pro Leu Ala Phe Ile Leu Asp Val Pro Glu Thr Pro Gly 
1               5                   10                  15      


Asp Gln Gly Gln Gly Pro Ser Pro Tyr Asp Glu Ser Glu Val His Asp 
            20                  25                  30          


Ser Phe Gln Gln Leu Ile Gln Glu Gln Ser Gln Cys Thr Ala Gln Glu 
        35                  40                  45              


Gly Leu Glu Leu Gln Gln Arg Glu Arg Glu Val Thr Gly Ser Ser Gln 
    50                  55                  60                  


Gln Thr Leu Trp Arg Pro Glu Gly Thr Gln Ser Thr Ala Thr Leu Arg 
65                  70                  75                  80  


Ile Leu Ala Ser Met Pro Ser Arg Thr Ile Gly Arg Ser Arg Gly Ala 
                85                  90                  95      


Ile Ile Ser Gln Tyr Tyr Asn Arg Thr Val Gln Leu Arg Cys Arg Ser 
            100                 105                 110         


Ser Arg Pro Leu Leu Gly Asn Phe Val Arg Ser Ala Trp Pro Ser Leu 
        115                 120                 125             


Arg Leu Tyr Asp Leu Glu Leu Asp Pro Thr Ala Leu Glu Glu Glu Glu 
    130                 135                 140                 


Lys Gln Ser Leu Leu Val Lys Glu Leu Gln Ser Leu Ala Val Ala Gln 
145                 150                 155                 160 


Arg Asp His Met Leu Arg Gly Met Pro Leu Ser Leu Ala Glu Lys Arg 
                165                 170                 175     


Ser Leu Arg Glu Lys Ser Arg Thr Pro Arg Gly Lys Trp Arg Gly Gln 
            180                 185                 190         


Pro Gly Ser Gly Gly Val Cys Ser Cys Cys Gly Arg Leu Arg Tyr Ala 
        195                 200                 205             


Cys Val Leu Ala Leu His Ser Leu Gly Leu Ala Leu Leu Ser Ala Leu 
    210                 215                 220                 


Gln Ala Leu Met Pro Trp Arg Tyr Ala Leu Lys Arg Ile Gly Gly Gln 
225                 230                 235                 240 


Phe Gly Ser Ser Val Leu Ser Tyr Phe Leu Phe Leu Lys Thr Leu Leu 
                245                 250                 255     


Ala Phe Asn Ala Leu Leu Leu Leu Leu Leu Val Ala Phe Ile Met Gly 
            260                 265                 270         


Pro Gln Val Ala Phe Pro Pro Ala Leu Pro Gly Pro Ala Pro Val Cys 
        275                 280                 285             


Thr Gly Leu Glu Leu Leu Thr Gly Ala Gly Cys Phe Thr His Thr Val 
    290                 295                 300                 


Met Tyr Tyr Gly His Tyr Ser Asn Ala Thr Leu Asn Gln Pro Cys Gly 
305                 310                 315                 320 


Ser Pro Leu Asp Gly Ser Gln Cys Thr Pro Arg Val Gly Gly Leu Pro 
                325                 330                 335     


Tyr Asn Met Pro Leu Ala Tyr Leu Ser Thr Val Gly Val Ser Phe Phe 
            340                 345                 350         


Ile Thr Cys Ile Thr Leu Val Tyr Ser Met Ala His Ser Phe Gly Glu 
        355                 360                 365             


Ser Tyr Arg Val Gly Ser Thr Ser Gly Ile His Ala Ile Thr Val Phe 
    370                 375                 380                 


Cys Ser Trp Asp Tyr Lys Val Thr Gln Lys Arg Ala Ser Arg Leu Gln 
385                 390                 395                 400 


Gln Asp Asn Ile Arg Thr Arg Leu Lys Glu Leu Leu Ala Glu Trp Gln 
                405                 410                 415     


Leu Arg His Ser Pro Arg Ser Val Cys Gly Arg Leu Arg Gln Ala Ala 
            420                 425                 430         


Val Leu Gly Leu Val Trp Leu Leu Cys Leu Gly Thr Ala Leu Gly Cys 
        435                 440                 445             


Ala Val Ala Val His Val Phe Ser Glu Phe Met Ile Gln Ser Pro Glu 
    450                 455                 460                 


Ala Ala Gly Gln Glu Ala Val Leu Leu Val Leu Pro Leu Val Val Gly 
465                 470                 475                 480 


Leu Leu Asn Leu Gly Ala Pro Tyr Leu Cys Arg Val Leu Ala Ala Leu 
                485                 490                 495     


Glu Pro His Asp Ser Pro Val Leu Glu Val Tyr Val Ala Ile Cys Arg 
            500                 505                 510         


Asn Leu Ile Leu Lys Leu Ala Ile Leu Gly Thr Leu Cys Tyr His Trp 
        515                 520                 525             


Leu Gly Arg Arg Val Gly Val Leu Gln Gly Gln Cys Trp Glu Asp Phe 
    530                 535                 540                 


Val Gly Gln Glu Leu Tyr Arg Phe Leu Val Met Asp Phe Val Leu Met 
545                 550                 555                 560 


Leu Leu Asp Thr Leu Phe Gly Glu Leu Val Trp Arg Ile Ile Ser Glu 
                565                 570                 575     


Lys Lys Leu Lys Arg Arg Arg Lys Pro Glu Phe Asp Ile Ala Arg Asn 
            580                 585                 590         


Val Leu Glu Leu Ile Tyr Gly Gln Thr Leu Thr Trp Leu Gly Val Leu 
        595                 600                 605             


Phe Ser Pro Leu Leu Pro Ala Val Gln Ile Ile Lys Leu Leu Leu Val 
    610                 615                 620                 


Phe Tyr Val Lys Lys Thr Ser Leu Leu Ala Asn Cys Gln Ala Pro Arg 
625                 630                 635                 640 


Arg Pro Trp Leu Ala Ser His Met Ser Thr Val Phe Leu Thr Leu Leu 
                645                 650                 655     


Cys Phe Pro Ala Phe Leu Gly Ala Ala Val Phe Leu Cys Tyr Ala Val 
            660                 665                 670         


Trp Gln Val Lys Pro Ser Ser Thr Cys Gly Pro Phe Arg Thr Leu Asp 
        675                 680                 685             


Thr Met Tyr Glu Ala Gly Arg Val Trp Val Arg His Leu Glu Ala Ala 
    690                 695                 700                 


Gly Pro Arg Val Ser Trp Leu Pro Trp Val His Arg Tyr Leu Met Glu 
705                 710                 715                 720 


Asn Thr Phe Phe Val Phe Leu Val Ser Ala Leu Leu Leu Ala Val Ile 
                725                 730                 735     


Tyr Leu Asn Ile Gln Val Val Arg Gly Gln Arg Lys Val Ile Cys Leu 
            740                 745                 750         


Leu Lys Glu Gln Ile Ser Asn Glu Gly Glu Asp Lys Ile Phe Leu Ile 
        755                 760                 765             


Asn Lys Leu His Ser Ile Tyr Glu Arg Lys Glu Arg Glu Glu Arg Ser 
    770                 775                 780                 


Arg Val Gly Thr Thr Glu Glu Ala Ala Ala Pro Pro Ala Leu Leu Thr 
785                 790                 795                 800 


Asp Glu Gln Asp Ala 
                805 


<210>  3666
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  3666

Met Gly Ile Leu Leu Gly Leu Leu Leu Leu Gly His Leu Thr Val Asp 
1               5                   10                  15      


Thr Tyr Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro 
            20                  25                  30          


Trp Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly 
        35                  40                  45              


Tyr Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro 
    50                  55                  60                  


Val Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala 
65                  70                  75                  80  


Lys Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val 
                85                  90                  95      


Ser Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr 
            100                 105                 110         


Cys Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp 
        115                 120                 125             


Lys Ile Thr Glu Leu Arg Val Gln Lys Leu Ser Val Ser Lys Pro Thr 
    130                 135                 140                 


Val Thr Thr Gly Ser Gly Tyr Gly Phe Thr Val Pro Gln Gly Met Arg 
145                 150                 155                 160 


Ile Ser Leu Gln Cys Gln Ala Arg Gly Ser Pro Pro Ile Ser Tyr Ile 
                165                 170                 175     


Trp Tyr Lys Gln Gln Thr Asn Asn Gln Glu Pro Ile Lys Val Ala Thr 
            180                 185                 190         


Leu Ser Thr Leu Leu Phe Lys Pro Ala Val Ile Ala Asp Ser Gly Ser 
        195                 200                 205             


Tyr Phe Cys Thr Ala Lys Gly Gln Val Gly Ser Glu Gln His Ser Asp 
    210                 215                 220                 


Ile Val Lys Phe Val Val Lys Asp Ser Ser Lys Leu Leu Lys Thr Lys 
225                 230                 235                 240 


Thr Glu Ala Pro Thr Thr Met Thr Tyr Pro Leu Lys Ala Thr Ser Thr 
                245                 250                 255     


Val Lys Gln Ser Trp Asp Trp Thr Thr Asp Met Asp Gly Tyr Leu Gly 
            260                 265                 270         


Glu Thr Ser Ala Gly Pro Gly Lys Ser Leu Pro Val Phe Ala Ile Ile 
        275                 280                 285             


Leu Ile Ile Ser Leu Cys Cys Met Val Val Phe Thr Met Ala Tyr Ile 
    290                 295                 300                 


Met Leu Cys Arg Lys Thr Ser Gln Gln Glu His Val Tyr Glu Ala Ala 
305                 310                 315                 320 


Arg Ala His Ala Arg Glu Ala Asn Asp Ser Gly Glu Thr Met Arg Val 
                325                 330                 335     


Ala Ile Phe Ala Ser Gly Cys Ser Ser Asp Glu Pro Thr Ser Gln Asn 
            340                 345                 350         


Leu Gly Asn Asn Tyr Ser Asp Glu Pro Cys Ile Gly Gln Glu Tyr Gln 
        355                 360                 365             


Ile Ile Ala Gln Ile Asn Gly Asn Tyr Ala Arg Leu Leu Asp Thr Val 
    370                 375                 380                 


Pro Leu Asp Tyr Glu Phe Leu Ala Thr Glu Gly Lys Ser Val Cys 
385                 390                 395                 


<210>  3667
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  3667

Met Lys Leu Met Val Leu Val Phe Thr Ile Gly Leu Thr Leu Leu Leu 
1               5                   10                  15      


Gly Val Gln Ala Met Pro Ala Asn Arg Leu Ser Cys Tyr Arg Lys Ile 
            20                  25                  30          


Leu Lys Asp His Asn Cys His Asn Leu Pro Glu Gly Val Ala Asp Leu 
        35                  40                  45              


Thr Gln Ile Asp Val Asn Val Gln Asp His Phe Trp Asp Gly Lys Gly 
    50                  55                  60                  


Cys Glu Met Ile Cys Tyr Cys Asn Phe Ser Glu Leu Leu Cys Cys Pro 
65                  70                  75                  80  


Lys Asp Val Phe Phe Gly Pro Lys Ile Ser Phe Val Ile Pro Cys Asn 
                85                  90                  95      


Asn Gln 
        


<210>  3668
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  3668

Met Leu Leu Ser Ile Gly Met Leu Met Leu Ser Ala Thr Gln Val Tyr 
1               5                   10                  15      


Thr Ile Leu Thr Val Gln Leu Phe Ala Phe Leu Asn Leu Leu Pro Val 
            20                  25                  30          


Glu Ala Asp Ile Leu Ala Tyr Asn Phe Glu Asn Ala Ser Gln Thr Phe 
        35                  40                  45              


Asp Asp Leu Pro Ala Arg Phe Gly Tyr Arg Leu Pro Ala Glu Gly Leu 
    50                  55                  60                  


Lys Gly Phe Leu Ile Asn Ser Lys Pro Glu Asn Ala Cys Glu Pro Ile 
65                  70                  75                  80  


Val Pro Pro Pro Val Lys Asp Asn Ser Ser Gly Thr Phe Ile Val Leu 
                85                  90                  95      


Ile Arg Arg Leu Asp Cys Asn Phe Asp Ile Lys Val Leu Asn Ala Gln 
            100                 105                 110         


Arg Ala Gly Tyr Lys Ala Ala Ile Val His Asn Val Asp Ser Asp Asp 
        115                 120                 125             


Leu Ile Ser Met Gly Ser Asn Asp Ile Glu Val Leu Lys Lys Ile Asp 
    130                 135                 140                 


Ile Pro Ser Val Phe Ile Gly Glu Ser Ser Ala Asn Ser Leu Lys Asp 
145                 150                 155                 160 


Glu Phe Thr Tyr Glu Lys Gly Gly His Leu Ile Leu Val Pro Glu Phe 
                165                 170                 175     


Ser Leu Pro Leu Glu Tyr Tyr Leu Ile Pro Phe Leu Ile Ile Val Gly 
            180                 185                 190         


Ile Cys Leu Ile Leu Ile Val Ile Phe Met Ile Thr Lys Phe Val Gln 
        195                 200                 205             


Asp Arg His Arg Ala Arg Arg Asn Arg Leu Arg Lys Asp Gln Leu Lys 
    210                 215                 220                 


Lys Leu Pro Val His Lys Phe Lys Lys Gly Asp Glu Tyr Asp Val Cys 
225                 230                 235                 240 


Ala Ile Cys Leu Asp Glu Tyr Glu Asp Gly Asp Lys Leu Arg Ile Leu 
                245                 250                 255     


Pro Cys Ser His Ala Tyr His Cys Lys Cys Val Asp Pro Trp Leu Thr 
            260                 265                 270         


Lys Thr Lys Lys Thr Cys Pro Val Cys Lys Gln Lys Val Val Pro Ser 
        275                 280                 285             


Gln Gly Asp Ser Asp Ser Asp Thr Asp Ser Ser Gln Glu Glu Asn Glu 
    290                 295                 300                 


Val Thr Glu His Thr Pro Leu Leu Arg Pro Leu Ala Ser Val Ser Ala 
305                 310                 315                 320 


Gln Ser Phe Gly Ala Leu Ser Glu Ser Arg Ser His Gln Asn Met Thr 
                325                 330                 335     


Glu Ser Ser Asp Tyr Glu Glu Asp Asp Asn Glu Asp Thr Asp Ser Ser 
            340                 345                 350         


Asp Ala Glu Asn Glu Ile Asn Glu His Asp Val Val Val Gln Leu Gln 
        355                 360                 365             


Pro Asn Gly Glu Arg Asp Tyr Asn Ile Ala Asn Thr Val 
    370                 375                 380     


<210>  3669
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  3669

Met Gly Lys Ser Glu Ser Gln Met Asp Ile Thr Asp Ile Asn Thr Pro 
1               5                   10                  15      


Lys Pro Lys Lys Lys Gln Arg Trp Thr Pro Leu Glu Ile Ser Leu Ser 
            20                  25                  30          


Val Leu Val Leu Leu Leu Thr Ile Ile Ala Val Thr Met Ile Ala Leu 
        35                  40                  45              


Tyr Ala Thr Tyr Asp Asp Gly Ile Cys Lys Ser Ser Asp Cys Ile Lys 
    50                  55                  60                  


Ser Ala Ala Arg Leu Ile Gln Asn Met Asp Ala Thr Thr Glu Pro Cys 
65                  70                  75                  80  


Thr Asp Phe Phe Lys Tyr Ala Cys Gly Gly Trp Leu Lys Arg Asn Val 
                85                  90                  95      


Ile Pro Glu Thr Ser Ser Arg Tyr Gly Asn Phe Asp Ile Leu Arg Asp 
            100                 105                 110         


Glu Leu Glu Val Val Leu Lys Asp Val Leu Gln Glu Pro Lys Thr Glu 
        115                 120                 125             


Asp Ile Val Ala Val Gln Lys Ala Lys Ala Leu Tyr Arg Ser Cys Ile 
    130                 135                 140                 


Asn Glu Ser Ala Ile Asp Ser Arg Gly Gly Glu Pro Leu Leu Lys Leu 
145                 150                 155                 160 


Leu Pro Asp Ile Tyr Gly Trp Pro Val Ala Thr Glu Asn Trp Glu Gln 
                165                 170                 175     


Lys Tyr Gly Ala Ser Trp Thr Ala Glu Lys Ala Ile Ala Gln Leu Asn 
            180                 185                 190         


Ser Lys Tyr Gly Lys Lys Val Leu Ile Asn Leu Phe Val Gly Thr Asp 
        195                 200                 205             


Asp Lys Asn Ser Val Asn His Val Ile His Ile Asp Gln Pro Arg Leu 
    210                 215                 220                 


Gly Leu Pro Ser Arg Asp Tyr Tyr Glu Cys Thr Gly Ile Tyr Lys Glu 
225                 230                 235                 240 


Ala Cys Thr Ala Tyr Val Asp Phe Met Ile Ser Val Ala Arg Leu Ile 
                245                 250                 255     


Arg Gln Glu Glu Arg Leu Pro Ile Asp Glu Asn Gln Leu Ala Leu Glu 
            260                 265                 270         


Met Asn Lys Val Met Glu Leu Glu Lys Glu Ile Ala Asn Ala Thr Ala 
        275                 280                 285             


Lys Pro Glu Asp Arg Asn Asp Pro Met Leu Leu Tyr Asn Lys Met Thr 
    290                 295                 300                 


Leu Ala Gln Ile Gln Asn Asn Phe Ser Leu Glu Ile Asn Gly Lys Pro 
305                 310                 315                 320 


Phe Ser Trp Leu Asn Phe Thr Asn Glu Ile Met Ser Thr Val Asn Ile 
                325                 330                 335     


Ser Ile Thr Asn Glu Glu Asp Val Val Val Tyr Ala Pro Glu Tyr Leu 
            340                 345                 350         


Thr Lys Leu Lys Pro Ile Leu Thr Lys Tyr Ser Ala Arg Asp Leu Gln 
        355                 360                 365             


Asn Leu Met Ser Trp Arg Phe Ile Met Asp Leu Val Ser Ser Leu Ser 
    370                 375                 380                 


Arg Thr Tyr Lys Glu Ser Arg Asn Ala Phe Arg Lys Ala Leu Tyr Gly 
385                 390                 395                 400 


Thr Thr Ser Glu Thr Ala Thr Trp Arg Arg Cys Ala Asn Tyr Val Asn 
                405                 410                 415     


Gly Asn Met Glu Asn Ala Val Gly Arg Leu Tyr Val Glu Ala Ala Phe 
            420                 425                 430         


Ala Gly Glu Ser Lys His Val Val Glu Asp Leu Ile Ala Gln Ile Arg 
        435                 440                 445             


Glu Val Phe Ile Gln Thr Leu Asp Asp Leu Thr Trp Met Asp Ala Glu 
    450                 455                 460                 


Thr Lys Lys Arg Ala Glu Glu Lys Ala Leu Ala Ile Lys Glu Arg Ile 
465                 470                 475                 480 


Gly Tyr Pro Asp Asp Ile Val Ser Asn Asp Asn Lys Leu Asn Asn Glu 
                485                 490                 495     


Tyr Leu Glu Leu Asn Tyr Lys Glu Asp Glu Tyr Phe Glu Asn Ile Ile 
            500                 505                 510         


Gln Asn Leu Lys Phe Ser Gln Ser Lys Gln Leu Lys Lys Leu Arg Glu 
        515                 520                 525             


Lys Val Asp Lys Asp Glu Trp Ile Ser Gly Ala Ala Val Val Asn Ala 
    530                 535                 540                 


Phe Tyr Ser Ser Gly Arg Asn Gln Ile Val Phe Pro Ala Gly Ile Leu 
545                 550                 555                 560 


Gln Pro Pro Phe Phe Ser Ala Gln Gln Ser Asn Ser Leu Asn Tyr Gly 
                565                 570                 575     


Gly Ile Gly Met Val Ile Gly His Glu Ile Thr His Gly Phe Asp Asp 
            580                 585                 590         


Asn Gly Arg Asn Phe Asn Lys Asp Gly Asp Leu Val Asp Trp Trp Thr 
        595                 600                 605             


Gln Gln Ser Ala Ser Asn Phe Lys Glu Gln Ser Gln Cys Met Val Tyr 
    610                 615                 620                 


Gln Tyr Gly Asn Phe Ser Trp Asp Leu Ala Gly Gly Gln His Leu Asn 
625                 630                 635                 640 


Gly Ile Asn Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Gly 
                645                 650                 655     


Gln Ala Tyr Arg Ala Tyr Gln Asn Tyr Ile Lys Lys Asn Gly Glu Glu 
            660                 665                 670         


Lys Leu Leu Pro Gly Leu Asp Leu Asn His Lys Gln Leu Phe Phe Leu 
        675                 680                 685             


Asn Phe Ala Gln Val Trp Cys Gly Thr Tyr Arg Pro Glu Tyr Ala Val 
    690                 695                 700                 


Asn Ser Ile Lys Thr Asp Val His Ser Pro Gly Asn Phe Arg Ile Ile 
705                 710                 715                 720 


Gly Thr Leu Gln Asn Ser Ala Glu Phe Ser Glu Ala Phe His Cys Arg 
                725                 730                 735     


Lys Asn Ser Tyr Met Asn Pro Glu Lys Lys Cys Arg Val Trp 
            740                 745                 750 


<210>  3670
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  3670

Met Gly Lys Ser Glu Ser Gln Met Asp Ile Thr Asp Ile Asn Thr Pro 
1               5                   10                  15      


Lys Pro Lys Lys Lys Gln Arg Trp Thr Pro Leu Glu Ile Ser Leu Ser 
            20                  25                  30          


Val Leu Val Leu Leu Leu Thr Ile Ile Ala Val Thr Met Ile Ala Leu 
        35                  40                  45              


Tyr Ala Thr Tyr Asp Asp Gly Ile Cys Lys Ser Ser Asp Cys Ile Lys 
    50                  55                  60                  


Ser Ala Ala Arg Leu Ile Gln Asn Met Asp Ala Thr Thr Glu Pro Cys 
65                  70                  75                  80  


Thr Asp Phe Phe Lys Tyr Ala Cys Gly Gly Trp Leu Lys Arg Asn Val 
                85                  90                  95      


Ile Pro Glu Thr Ser Ser Arg Tyr Gly Asn Phe Asp Ile Leu Arg Asp 
            100                 105                 110         


Glu Leu Glu Val Val Leu Lys Asp Val Leu Gln Glu Pro Lys Thr Glu 
        115                 120                 125             


Asp Ile Val Ala Val Gln Lys Ala Lys Ala Leu Tyr Arg Ser Cys Ile 
    130                 135                 140                 


Asn Glu Ser Ala Ile Asp Ser Arg Gly Gly Glu Pro Leu Leu Lys Leu 
145                 150                 155                 160 


Leu Pro Asp Ile Tyr Gly Trp Pro Val Ala Thr Glu Asn Trp Glu Gln 
                165                 170                 175     


Lys Tyr Gly Ala Ser Trp Thr Ala Glu Lys Ala Ile Ala Gln Leu Asn 
            180                 185                 190         


Ser Lys Tyr Gly Lys Lys Val Leu Ile Asn Leu Phe Val Gly Thr Asp 
        195                 200                 205             


Asp Lys Asn Ser Val Asn His Val Ile His Ile Asp Gln Pro Arg Leu 
    210                 215                 220                 


Gly Leu Pro Ser Arg Asp Tyr Tyr Glu Cys Thr Gly Ile Tyr Lys Glu 
225                 230                 235                 240 


Ala Cys Thr Ala Tyr Val Asp Phe Met Ile Ser Val Ala Arg Leu Ile 
                245                 250                 255     


Arg Gln Glu Glu Arg Leu Pro Ile Asp Glu Asn Gln Leu Ala Leu Glu 
            260                 265                 270         


Met Asn Lys Val Met Glu Leu Glu Lys Glu Ile Ala Asn Ala Thr Ala 
        275                 280                 285             


Lys Pro Glu Asp Arg Asn Asp Pro Met Leu Leu Tyr Asn Lys Met Thr 
    290                 295                 300                 


Leu Ala Gln Ile Gln Asn Asn Phe Ser Leu Glu Ile Asn Gly Lys Pro 
305                 310                 315                 320 


Phe Ser Trp Leu Asn Phe Thr Asn Glu Ile Met Ser Thr Val Asn Ile 
                325                 330                 335     


Ser Ile Thr Asn Glu Glu Asp Val Val Val Tyr Ala Pro Glu Tyr Leu 
            340                 345                 350         


Thr Lys Leu Lys Pro Ile Leu Thr Lys Tyr Ser Ala Arg Asp Leu Gln 
        355                 360                 365             


Asn Leu Met Ser Trp Arg Phe Ile Met Asp Leu Val Ser Ser Leu Ser 
    370                 375                 380                 


Arg Thr Tyr Lys Glu Ser Arg Asn Ala Phe Arg Lys Ala Leu Tyr Gly 
385                 390                 395                 400 


Thr Thr Ser Glu Thr Ala Thr Trp Arg Arg Cys Ala Asn Tyr Val Asn 
                405                 410                 415     


Gly Asn Met Glu Asn Ala Val Gly Arg Leu Tyr Val Glu Ala Ala Phe 
            420                 425                 430         


Ala Gly Glu Ser Lys His Val Val Glu Asp Leu Ile Ala Gln Ile Arg 
        435                 440                 445             


Glu Val Phe Ile Gln Thr Leu Asp Asp Leu Thr Trp Met Asp Ala Glu 
    450                 455                 460                 


Thr Lys Lys Arg Ala Glu Glu Lys Ala Leu Ala Ile Lys Glu Arg Ile 
465                 470                 475                 480 


Gly Tyr Pro Asp Asp Ile Val Ser Asn Asp Asn Lys Leu Asn Asn Glu 
                485                 490                 495     


Tyr Leu Glu Leu Asn Tyr Lys Glu Asp Glu Tyr Phe Glu Asn Ile Ile 
            500                 505                 510         


Gln Asn Leu Lys Phe Ser Gln Ser Lys Gln Leu Lys Lys Leu Arg Glu 
        515                 520                 525             


Lys Val Asp Lys Asp Glu Trp Ile Ser Gly Ala Ala Val Val Asn Ala 
    530                 535                 540                 


Phe Tyr Ser Ser Gly Arg Asn Gln Ile Val Phe Pro Ala Gly Ile Leu 
545                 550                 555                 560 


Gln Pro Pro Phe Phe Ser Ala Gln Gln Ser Asn Ser Leu Asn Tyr Gly 
                565                 570                 575     


Gly Ile Gly Met Val Ile Gly His Glu Ile Thr His Gly Phe Asp Asp 
            580                 585                 590         


Asn Gly Arg Asn Phe Asn Lys Asp Gly Asp Leu Val Asp Trp Trp Thr 
        595                 600                 605             


Gln Gln Ser Ala Ser Asn Phe Lys Glu Gln Ser Gln Cys Met Val Tyr 
    610                 615                 620                 


Gln Tyr Gly Asn Phe Ser Trp Asp Leu Ala Gly Gly Gln His Leu Asn 
625                 630                 635                 640 


Gly Ile Asn Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Gly 
                645                 650                 655     


Gln Ala Tyr Arg Ala Tyr Gln Asn Tyr Ile Lys Lys Asn Gly Glu Glu 
            660                 665                 670         


Lys Leu Leu Pro Gly Leu Asp Leu Asn His Lys Gln Leu Phe Phe Leu 
        675                 680                 685             


Asn Phe Ala Gln Val Trp Cys Gly Thr Tyr Arg Pro Glu Tyr Ala Val 
    690                 695                 700                 


Asn Ser Ile Lys Thr Asp Val His Ser Pro Gly Asn Phe Arg Ile Ile 
705                 710                 715                 720 


Gly Thr Leu Gln Asn Ser Ala Glu Phe Ser Glu Ala Phe His Cys Arg 
                725                 730                 735     


Lys Asn Ser Tyr Met Asn Pro Glu Lys Lys Cys Arg Val Trp 
            740                 745                 750 


<210>  3671
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  3671

Met Gly Lys Ser Glu Ser Gln Met Asp Ile Thr Asp Ile Asn Thr Pro 
1               5                   10                  15      


Lys Pro Lys Lys Lys Gln Arg Trp Thr Pro Leu Glu Ile Ser Leu Ser 
            20                  25                  30          


Val Leu Val Leu Leu Leu Thr Ile Ile Ala Val Thr Met Ile Ala Leu 
        35                  40                  45              


Tyr Ala Thr Tyr Asp Asp Gly Ile Cys Lys Ser Ser Asp Cys Ile Lys 
    50                  55                  60                  


Ser Ala Ala Arg Leu Ile Gln Asn Met Asp Ala Thr Thr Glu Pro Cys 
65                  70                  75                  80  


Thr Asp Phe Phe Lys Tyr Ala Cys Gly Gly Trp Leu Lys Arg Asn Val 
                85                  90                  95      


Ile Pro Glu Thr Ser Ser Arg Tyr Gly Asn Phe Asp Ile Leu Arg Asp 
            100                 105                 110         


Glu Leu Glu Val Val Leu Lys Asp Val Leu Gln Glu Pro Lys Thr Glu 
        115                 120                 125             


Asp Ile Val Ala Val Gln Lys Ala Lys Ala Leu Tyr Arg Ser Cys Ile 
    130                 135                 140                 


Asn Glu Ser Ala Ile Asp Ser Arg Gly Gly Glu Pro Leu Leu Lys Leu 
145                 150                 155                 160 


Leu Pro Asp Ile Tyr Gly Trp Pro Val Ala Thr Glu Asn Trp Glu Gln 
                165                 170                 175     


Lys Tyr Gly Ala Ser Trp Thr Ala Glu Lys Ala Ile Ala Gln Leu Asn 
            180                 185                 190         


Ser Lys Tyr Gly Lys Lys Val Leu Ile Asn Leu Phe Val Gly Thr Asp 
        195                 200                 205             


Asp Lys Asn Ser Val Asn His Val Ile His Ile Asp Gln Pro Arg Leu 
    210                 215                 220                 


Gly Leu Pro Ser Arg Asp Tyr Tyr Glu Cys Thr Gly Ile Tyr Lys Glu 
225                 230                 235                 240 


Ala Cys Thr Ala Tyr Val Asp Phe Met Ile Ser Val Ala Arg Leu Ile 
                245                 250                 255     


Arg Gln Glu Glu Arg Leu Pro Ile Asp Glu Asn Gln Leu Ala Leu Glu 
            260                 265                 270         


Met Asn Lys Val Met Glu Leu Glu Lys Glu Ile Ala Asn Ala Thr Ala 
        275                 280                 285             


Lys Pro Glu Asp Arg Asn Asp Pro Met Leu Leu Tyr Asn Lys Met Thr 
    290                 295                 300                 


Leu Ala Gln Ile Gln Asn Asn Phe Ser Leu Glu Ile Asn Gly Lys Pro 
305                 310                 315                 320 


Phe Ser Trp Leu Asn Phe Thr Asn Glu Ile Met Ser Thr Val Asn Ile 
                325                 330                 335     


Ser Ile Thr Asn Glu Glu Asp Val Val Val Tyr Ala Pro Glu Tyr Leu 
            340                 345                 350         


Thr Lys Leu Lys Pro Ile Leu Thr Lys Tyr Ser Ala Arg Asp Leu Gln 
        355                 360                 365             


Asn Leu Met Ser Trp Arg Phe Ile Met Asp Leu Val Ser Ser Leu Ser 
    370                 375                 380                 


Arg Thr Tyr Lys Glu Ser Arg Asn Ala Phe Arg Lys Ala Leu Tyr Gly 
385                 390                 395                 400 


Thr Thr Ser Glu Thr Ala Thr Trp Arg Arg Cys Ala Asn Tyr Val Asn 
                405                 410                 415     


Gly Asn Met Glu Asn Ala Val Gly Arg Leu Tyr Val Glu Ala Ala Phe 
            420                 425                 430         


Ala Gly Glu Ser Lys His Val Val Glu Asp Leu Ile Ala Gln Ile Arg 
        435                 440                 445             


Glu Val Phe Ile Gln Thr Leu Asp Asp Leu Thr Trp Met Asp Ala Glu 
    450                 455                 460                 


Thr Lys Lys Arg Ala Glu Glu Lys Ala Leu Ala Ile Lys Glu Arg Ile 
465                 470                 475                 480 


Gly Tyr Pro Asp Asp Ile Val Ser Asn Asp Asn Lys Leu Asn Asn Glu 
                485                 490                 495     


Tyr Leu Glu Leu Asn Tyr Lys Glu Asp Glu Tyr Phe Glu Asn Ile Ile 
            500                 505                 510         


Gln Asn Leu Lys Phe Ser Gln Ser Lys Gln Leu Lys Lys Leu Arg Glu 
        515                 520                 525             


Lys Val Asp Lys Asp Glu Trp Ile Ser Gly Ala Ala Val Val Asn Ala 
    530                 535                 540                 


Phe Tyr Ser Ser Gly Arg Asn Gln Ile Val Phe Pro Ala Gly Ile Leu 
545                 550                 555                 560 


Gln Pro Pro Phe Phe Ser Ala Gln Gln Ser Asn Ser Leu Asn Tyr Gly 
                565                 570                 575     


Gly Ile Gly Met Val Ile Gly His Glu Ile Thr His Gly Phe Asp Asp 
            580                 585                 590         


Asn Gly Arg Asn Phe Asn Lys Asp Gly Asp Leu Val Asp Trp Trp Thr 
        595                 600                 605             


Gln Gln Ser Ala Ser Asn Phe Lys Glu Gln Ser Gln Cys Met Val Tyr 
    610                 615                 620                 


Gln Tyr Gly Asn Phe Ser Trp Asp Leu Ala Gly Gly Gln His Leu Asn 
625                 630                 635                 640 


Gly Ile Asn Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Gly 
                645                 650                 655     


Gln Ala Tyr Arg Ala Tyr Gln Asn Tyr Ile Lys Lys Asn Gly Glu Glu 
            660                 665                 670         


Lys Leu Leu Pro Gly Leu Asp Leu Asn His Lys Gln Leu Phe Phe Leu 
        675                 680                 685             


Asn Phe Ala Gln Val Trp Cys Gly Thr Tyr Arg Pro Glu Tyr Ala Val 
    690                 695                 700                 


Asn Ser Ile Lys Thr Asp Val His Ser Pro Gly Asn Phe Arg Ile Ile 
705                 710                 715                 720 


Gly Thr Leu Gln Asn Ser Ala Glu Phe Ser Glu Ala Phe His Cys Arg 
                725                 730                 735     


Lys Asn Ser Tyr Met Asn Pro Glu Lys Lys Cys Arg Val Trp 
            740                 745                 750 


<210>  3672
<211>  1863
<212>  PRT
<213>  Homo sapiens

<400>  3672

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 
            180                 185                 190         


Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 
        195                 200                 205             


Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu 
            260                 265                 270         


Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn Ser 
        275                 280                 285             


Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe 
    290                 295                 300                 


Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg 
305                 310                 315                 320 


Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser Thr 
                325                 330                 335     


Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu 
            340                 345                 350         


Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr Glu 
        355                 360                 365             


Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn Glu 
    370                 375                 380                 


Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp 
385                 390                 395                 400 


Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu 
                405                 410                 415     


Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu 
            420                 425                 430         


Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His 
        435                 440                 445             


Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Thr 
    450                 455                 460                 


Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu Asn 
465                 470                 475                 480 


Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu Arg 
                485                 490                 495     


Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly Leu 
            500                 505                 510         


His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Thr 
        515                 520                 525             


Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly Gln 
    530                 535                 540                 


Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly Asp 
545                 550                 555                 560 


Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys 
                565                 570                 575     


Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser 
            580                 585                 590         


Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys 
        595                 600                 605             


Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu Glu 
    610                 615                 620                 


Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu Gln 
625                 630                 635                 640 


Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn 
                645                 650                 655     


Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys 
            660                 665                 670         


Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Thr 
        675                 680                 685             


Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr Asn 
    690                 695                 700                 


Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys Glu 
705                 710                 715                 720 


Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu 
                725                 730                 735     


Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu 
            740                 745                 750         


Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser Ser 
        755                 760                 765             


Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile Ser 
    770                 775                 780                 


Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn Lys 
785                 790                 795                 800 


Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His 
                805                 810                 815     


Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr Pro 
            820                 825                 830         


Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met Glu 
        835                 840                 845             


Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val Ser 
    850                 855                 860                 


Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu Glu 
865                 870                 875                 880 


Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser 
                885                 890                 895     


Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys 
            900                 905                 910         


Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala Gly 
        915                 920                 925             


Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys 
    930                 935                 940                 


Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly 
945                 950                 955                 960 


Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln Asn 
                965                 970                 975     


Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys Thr 
            980                 985                 990         


Lys Cys Lys Lys Asn Leu Leu Glu  Glu Asn Phe Glu Glu  His Ser Met 
        995                 1000                 1005             


Ser Pro  Glu Arg Glu Met Gly  Asn Glu Asn Ile Pro  Ser Thr Val 
    1010                 1015                 1020             


Ser Thr  Ile Ser Arg Asn Asn  Ile Arg Glu Asn Val  Phe Lys Glu 
    1025                 1030                 1035             


Ala Ser  Ser Ser Asn Ile Asn  Glu Val Gly Ser Ser  Thr Asn Glu 
    1040                 1045                 1050             


Val Gly  Ser Ser Ile Asn Glu  Ile Gly Ser Ser Asp  Glu Asn Ile 
    1055                 1060                 1065             


Gln Ala  Glu Leu Gly Arg Asn  Arg Gly Pro Lys Leu  Asn Ala Met 
    1070                 1075                 1080             


Leu Arg  Leu Gly Val Leu Gln  Pro Glu Val Tyr Lys  Gln Ser Leu 
    1085                 1090                 1095             


Pro Gly  Ser Asn Cys Lys His  Pro Glu Ile Lys Lys  Gln Glu Tyr 
    1100                 1105                 1110             


Glu Glu  Val Val Gln Thr Val  Asn Thr Asp Phe Ser  Pro Tyr Leu 
    1115                 1120                 1125             


Ile Ser  Asp Asn Leu Glu Gln  Pro Met Gly Ser Ser  His Ala Ser 
    1130                 1135                 1140             


Gln Val  Cys Ser Glu Thr Pro  Asp Asp Leu Leu Asp  Asp Gly Glu 
    1145                 1150                 1155             


Ile Lys  Glu Asp Thr Ser Phe  Ala Glu Asn Asp Ile  Lys Glu Ser 
    1160                 1165                 1170             


Ser Ala  Val Phe Ser Lys Ser  Val Gln Lys Gly Glu  Leu Ser Arg 
    1175                 1180                 1185             


Ser Pro  Ser Pro Phe Thr His  Thr His Leu Ala Gln  Gly Tyr Arg 
    1190                 1195                 1200             


Arg Gly  Ala Lys Lys Leu Glu  Ser Ser Glu Glu Asn  Leu Ser Ser 
    1205                 1210                 1215             


Glu Asp  Glu Glu Leu Pro Cys  Phe Gln His Leu Leu  Phe Gly Lys 
    1220                 1225                 1230             


Val Asn  Asn Ile Pro Ser Gln  Ser Thr Arg His Ser  Thr Val Ala 
    1235                 1240                 1245             


Thr Glu  Cys Leu Ser Lys Asn  Thr Glu Glu Asn Leu  Leu Ser Leu 
    1250                 1255                 1260             


Lys Asn  Ser Leu Asn Asp Cys  Ser Asn Gln Val Ile  Leu Ala Lys 
    1265                 1270                 1275             


Ala Ser  Gln Glu His His Leu  Ser Glu Glu Thr Lys  Cys Ser Ala 
    1280                 1285                 1290             


Ser Leu  Phe Ser Ser Gln Cys  Ser Glu Leu Glu Asp  Leu Thr Ala 
    1295                 1300                 1305             


Asn Thr  Asn Thr Gln Asp Pro  Phe Leu Ile Gly Ser  Ser Lys Gln 
    1310                 1315                 1320             


Met Arg  His Gln Ser Glu Ser  Gln Gly Val Gly Leu  Ser Asp Lys 
    1325                 1330                 1335             


Glu Leu  Val Ser Asp Asp Glu  Glu Arg Gly Thr Gly  Leu Glu Glu 
    1340                 1345                 1350             


Asn Asn  Gln Glu Glu Gln Ser  Met Asp Ser Asn Leu  Gly Glu Ala 
    1355                 1360                 1365             


Ala Ser  Gly Cys Glu Ser Glu  Thr Ser Val Ser Glu  Asp Cys Ser 
    1370                 1375                 1380             


Gly Leu  Ser Ser Gln Ser Asp  Ile Leu Thr Thr Gln  Gln Arg Asp 
    1385                 1390                 1395             


Thr Met  Gln His Asn Leu Ile  Lys Leu Gln Gln Glu  Met Ala Glu 
    1400                 1405                 1410             


Leu Glu  Ala Val Leu Glu Gln  His Gly Ser Gln Pro  Ser Asn Ser 
    1415                 1420                 1425             


Tyr Pro  Ser Ile Ile Ser Asp  Ser Ser Ala Leu Glu  Asp Leu Arg 
    1430                 1435                 1440             


Asn Pro  Glu Gln Ser Thr Ser  Glu Lys Ala Val Leu  Thr Ser Gln 
    1445                 1450                 1455             


Lys Ser  Ser Glu Tyr Pro Ile  Ser Gln Asn Pro Glu  Gly Leu Ser 
    1460                 1465                 1470             


Ala Asp  Lys Phe Glu Val Ser  Ala Asp Ser Ser Thr  Ser Lys Asn 
    1475                 1480                 1485             


Lys Glu  Pro Gly Val Glu Arg  Ser Ser Pro Ser Lys  Cys Pro Ser 
    1490                 1495                 1500             


Leu Asp  Asp Arg Trp Tyr Met  His Ser Cys Ser Gly  Ser Leu Gln 
    1505                 1510                 1515             


Asn Arg  Asn Tyr Pro Ser Gln  Glu Glu Leu Ile Lys  Val Val Asp 
    1520                 1525                 1530             


Val Glu  Glu Gln Gln Leu Glu  Glu Ser Gly Pro His  Asp Leu Thr 
    1535                 1540                 1545             


Glu Thr  Ser Tyr Leu Pro Arg  Gln Asp Leu Glu Gly  Thr Pro Tyr 
    1550                 1555                 1560             


Leu Glu  Ser Gly Ile Ser Leu  Phe Ser Asp Asp Pro  Glu Ser Asp 
    1565                 1570                 1575             


Pro Ser  Glu Asp Arg Ala Pro  Glu Ser Ala Arg Val  Gly Asn Ile 
    1580                 1585                 1590             


Pro Ser  Ser Thr Ser Ala Leu  Lys Val Pro Gln Leu  Lys Val Ala 
    1595                 1600                 1605             


Glu Ser  Ala Gln Ser Pro Ala  Ala Ala His Thr Thr  Asp Thr Ala 
    1610                 1615                 1620             


Gly Tyr  Asn Ala Met Glu Glu  Ser Val Ser Arg Glu  Lys Pro Glu 
    1625                 1630                 1635             


Leu Thr  Ala Ser Thr Glu Arg  Val Asn Lys Arg Met  Ser Met Val 
    1640                 1645                 1650             


Val Ser  Gly Leu Thr Pro Glu  Glu Phe Met Leu Val  Tyr Lys Phe 
    1655                 1660                 1665             


Ala Arg  Lys His His Ile Thr  Leu Thr Asn Leu Ile  Thr Glu Glu 
    1670                 1675                 1680             


Thr Thr  His Val Val Met Lys  Thr Asp Ala Glu Phe  Val Cys Glu 
    1685                 1690                 1695             


Arg Thr  Leu Lys Tyr Phe Leu  Gly Ile Ala Gly Gly  Lys Trp Val 
    1700                 1705                 1710             


Val Ser  Tyr Phe Trp Val Thr  Gln Ser Ile Lys Glu  Arg Lys Met 
    1715                 1720                 1725             


Leu Asn  Glu His Asp Phe Glu  Val Arg Gly Asp Val  Val Asn Gly 
    1730                 1735                 1740             


Arg Asn  His Gln Gly Pro Lys  Arg Ala Arg Glu Ser  Gln Asp Arg 
    1745                 1750                 1755             


Lys Ile  Phe Arg Gly Leu Glu  Ile Cys Cys Tyr Gly  Pro Phe Thr 
    1760                 1765                 1770             


Asn Met  Pro Thr Asp Gln Leu  Glu Trp Met Val Gln  Leu Cys Gly 
    1775                 1780                 1785             


Ala Ser  Val Val Lys Glu Leu  Ser Ser Phe Thr Leu  Gly Thr Gly 
    1790                 1795                 1800             


Val His  Pro Ile Val Val Val  Gln Pro Asp Ala Trp  Thr Glu Asp 
    1805                 1810                 1815             


Asn Gly  Phe His Ala Ile Gly  Gln Met Cys Glu Ala  Pro Val Val 
    1820                 1825                 1830             


Thr Arg  Glu Trp Val Leu Asp  Ser Val Ala Leu Tyr  Gln Cys Gln 
    1835                 1840                 1845             


Glu Leu  Asp Thr Tyr Leu Ile  Pro Gln Ile Pro His  Ser His Tyr 
    1850                 1855                 1860             


<210>  3673
<211>  1863
<212>  PRT
<213>  Homo sapiens

<400>  3673

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 
            180                 185                 190         


Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 
        195                 200                 205             


Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu 
            260                 265                 270         


Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn Ser 
        275                 280                 285             


Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe 
    290                 295                 300                 


Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg 
305                 310                 315                 320 


Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser Thr 
                325                 330                 335     


Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu 
            340                 345                 350         


Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr Glu 
        355                 360                 365             


Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn Glu 
    370                 375                 380                 


Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp 
385                 390                 395                 400 


Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu 
                405                 410                 415     


Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu 
            420                 425                 430         


Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His 
        435                 440                 445             


Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Thr 
    450                 455                 460                 


Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu Asn 
465                 470                 475                 480 


Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu Arg 
                485                 490                 495     


Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly Leu 
            500                 505                 510         


His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Thr 
        515                 520                 525             


Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly Gln 
    530                 535                 540                 


Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly Asp 
545                 550                 555                 560 


Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys 
                565                 570                 575     


Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser 
            580                 585                 590         


Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys 
        595                 600                 605             


Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu Glu 
    610                 615                 620                 


Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu Gln 
625                 630                 635                 640 


Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn 
                645                 650                 655     


Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys 
            660                 665                 670         


Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Thr 
        675                 680                 685             


Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr Asn 
    690                 695                 700                 


Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys Glu 
705                 710                 715                 720 


Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu 
                725                 730                 735     


Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu 
            740                 745                 750         


Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser Ser 
        755                 760                 765             


Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile Ser 
    770                 775                 780                 


Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn Lys 
785                 790                 795                 800 


Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His 
                805                 810                 815     


Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr Pro 
            820                 825                 830         


Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met Glu 
        835                 840                 845             


Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val Ser 
    850                 855                 860                 


Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu Glu 
865                 870                 875                 880 


Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser 
                885                 890                 895     


Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys 
            900                 905                 910         


Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala Gly 
        915                 920                 925             


Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys 
    930                 935                 940                 


Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly 
945                 950                 955                 960 


Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln Asn 
                965                 970                 975     


Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys Thr 
            980                 985                 990         


Lys Cys Lys Lys Asn Leu Leu Glu  Glu Asn Phe Glu Glu  His Ser Met 
        995                 1000                 1005             


Ser Pro  Glu Arg Glu Met Gly  Asn Glu Asn Ile Pro  Ser Thr Val 
    1010                 1015                 1020             


Ser Thr  Ile Ser Arg Asn Asn  Ile Arg Glu Asn Val  Phe Lys Glu 
    1025                 1030                 1035             


Ala Ser  Ser Ser Asn Ile Asn  Glu Val Gly Ser Ser  Thr Asn Glu 
    1040                 1045                 1050             


Val Gly  Ser Ser Ile Asn Glu  Ile Gly Ser Ser Asp  Glu Asn Ile 
    1055                 1060                 1065             


Gln Ala  Glu Leu Gly Arg Asn  Arg Gly Pro Lys Leu  Asn Ala Met 
    1070                 1075                 1080             


Leu Arg  Leu Gly Val Leu Gln  Pro Glu Val Tyr Lys  Gln Ser Leu 
    1085                 1090                 1095             


Pro Gly  Ser Asn Cys Lys His  Pro Glu Ile Lys Lys  Gln Glu Tyr 
    1100                 1105                 1110             


Glu Glu  Val Val Gln Thr Val  Asn Thr Asp Phe Ser  Pro Tyr Leu 
    1115                 1120                 1125             


Ile Ser  Asp Asn Leu Glu Gln  Pro Met Gly Ser Ser  His Ala Ser 
    1130                 1135                 1140             


Gln Val  Cys Ser Glu Thr Pro  Asp Asp Leu Leu Asp  Asp Gly Glu 
    1145                 1150                 1155             


Ile Lys  Glu Asp Thr Ser Phe  Ala Glu Asn Asp Ile  Lys Glu Ser 
    1160                 1165                 1170             


Ser Ala  Val Phe Ser Lys Ser  Val Gln Lys Gly Glu  Leu Ser Arg 
    1175                 1180                 1185             


Ser Pro  Ser Pro Phe Thr His  Thr His Leu Ala Gln  Gly Tyr Arg 
    1190                 1195                 1200             


Arg Gly  Ala Lys Lys Leu Glu  Ser Ser Glu Glu Asn  Leu Ser Ser 
    1205                 1210                 1215             


Glu Asp  Glu Glu Leu Pro Cys  Phe Gln His Leu Leu  Phe Gly Lys 
    1220                 1225                 1230             


Val Asn  Asn Ile Pro Ser Gln  Ser Thr Arg His Ser  Thr Val Ala 
    1235                 1240                 1245             


Thr Glu  Cys Leu Ser Lys Asn  Thr Glu Glu Asn Leu  Leu Ser Leu 
    1250                 1255                 1260             


Lys Asn  Ser Leu Asn Asp Cys  Ser Asn Gln Val Ile  Leu Ala Lys 
    1265                 1270                 1275             


Ala Ser  Gln Glu His His Leu  Ser Glu Glu Thr Lys  Cys Ser Ala 
    1280                 1285                 1290             


Ser Leu  Phe Ser Ser Gln Cys  Ser Glu Leu Glu Asp  Leu Thr Ala 
    1295                 1300                 1305             


Asn Thr  Asn Thr Gln Asp Pro  Phe Leu Ile Gly Ser  Ser Lys Gln 
    1310                 1315                 1320             


Met Arg  His Gln Ser Glu Ser  Gln Gly Val Gly Leu  Ser Asp Lys 
    1325                 1330                 1335             


Glu Leu  Val Ser Asp Asp Glu  Glu Arg Gly Thr Gly  Leu Glu Glu 
    1340                 1345                 1350             


Asn Asn  Gln Glu Glu Gln Ser  Met Asp Ser Asn Leu  Gly Glu Ala 
    1355                 1360                 1365             


Ala Ser  Gly Cys Glu Ser Glu  Thr Ser Val Ser Glu  Asp Cys Ser 
    1370                 1375                 1380             


Gly Leu  Ser Ser Gln Ser Asp  Ile Leu Thr Thr Gln  Gln Arg Asp 
    1385                 1390                 1395             


Thr Met  Gln His Asn Leu Ile  Lys Leu Gln Gln Glu  Met Ala Glu 
    1400                 1405                 1410             


Leu Glu  Ala Val Leu Glu Gln  His Gly Ser Gln Pro  Ser Asn Ser 
    1415                 1420                 1425             


Tyr Pro  Ser Ile Ile Ser Asp  Ser Ser Ala Leu Glu  Asp Leu Arg 
    1430                 1435                 1440             


Asn Pro  Glu Gln Ser Thr Ser  Glu Lys Ala Val Leu  Thr Ser Gln 
    1445                 1450                 1455             


Lys Ser  Ser Glu Tyr Pro Ile  Ser Gln Asn Pro Glu  Gly Leu Ser 
    1460                 1465                 1470             


Ala Asp  Lys Phe Glu Val Ser  Ala Asp Ser Ser Thr  Ser Lys Asn 
    1475                 1480                 1485             


Lys Glu  Pro Gly Val Glu Arg  Ser Ser Pro Ser Lys  Cys Pro Ser 
    1490                 1495                 1500             


Leu Asp  Asp Arg Trp Tyr Met  His Ser Cys Ser Gly  Ser Leu Gln 
    1505                 1510                 1515             


Asn Arg  Asn Tyr Pro Ser Gln  Glu Glu Leu Ile Lys  Val Val Asp 
    1520                 1525                 1530             


Val Glu  Glu Gln Gln Leu Glu  Glu Ser Gly Pro His  Asp Leu Thr 
    1535                 1540                 1545             


Glu Thr  Ser Tyr Leu Pro Arg  Gln Asp Leu Glu Gly  Thr Pro Tyr 
    1550                 1555                 1560             


Leu Glu  Ser Gly Ile Ser Leu  Phe Ser Asp Asp Pro  Glu Ser Asp 
    1565                 1570                 1575             


Pro Ser  Glu Asp Arg Ala Pro  Glu Ser Ala Arg Val  Gly Asn Ile 
    1580                 1585                 1590             


Pro Ser  Ser Thr Ser Ala Leu  Lys Val Pro Gln Leu  Lys Val Ala 
    1595                 1600                 1605             


Glu Ser  Ala Gln Ser Pro Ala  Ala Ala His Thr Thr  Asp Thr Ala 
    1610                 1615                 1620             


Gly Tyr  Asn Ala Met Glu Glu  Ser Val Ser Arg Glu  Lys Pro Glu 
    1625                 1630                 1635             


Leu Thr  Ala Ser Thr Glu Arg  Val Asn Lys Arg Met  Ser Met Val 
    1640                 1645                 1650             


Val Ser  Gly Leu Thr Pro Glu  Glu Phe Met Leu Val  Tyr Lys Phe 
    1655                 1660                 1665             


Ala Arg  Lys His His Ile Thr  Leu Thr Asn Leu Ile  Thr Glu Glu 
    1670                 1675                 1680             


Thr Thr  His Val Val Met Lys  Thr Asp Ala Glu Phe  Val Cys Glu 
    1685                 1690                 1695             


Arg Thr  Leu Lys Tyr Phe Leu  Gly Ile Ala Gly Gly  Lys Trp Val 
    1700                 1705                 1710             


Val Ser  Tyr Phe Trp Val Thr  Gln Ser Ile Lys Glu  Arg Lys Met 
    1715                 1720                 1725             


Leu Asn  Glu His Asp Phe Glu  Val Arg Gly Asp Val  Val Asn Gly 
    1730                 1735                 1740             


Arg Asn  His Gln Gly Pro Lys  Arg Ala Arg Glu Ser  Gln Asp Arg 
    1745                 1750                 1755             


Lys Ile  Phe Arg Gly Leu Glu  Ile Cys Cys Tyr Gly  Pro Phe Thr 
    1760                 1765                 1770             


Asn Met  Pro Thr Asp Gln Leu  Glu Trp Met Val Gln  Leu Cys Gly 
    1775                 1780                 1785             


Ala Ser  Val Val Lys Glu Leu  Ser Ser Phe Thr Leu  Gly Thr Gly 
    1790                 1795                 1800             


Val His  Pro Ile Val Val Val  Gln Pro Asp Ala Trp  Thr Glu Asp 
    1805                 1810                 1815             


Asn Gly  Phe His Ala Ile Gly  Gln Met Cys Glu Ala  Pro Val Val 
    1820                 1825                 1830             


Thr Arg  Glu Trp Val Leu Asp  Ser Val Ala Leu Tyr  Gln Cys Gln 
    1835                 1840                 1845             


Glu Leu  Asp Thr Tyr Leu Ile  Pro Gln Ile Pro His  Ser His Tyr 
    1850                 1855                 1860             


<210>  3674
<211>  1863
<212>  PRT
<213>  Homo sapiens

<400>  3674

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 
            180                 185                 190         


Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 
        195                 200                 205             


Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu 
            260                 265                 270         


Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn Ser 
        275                 280                 285             


Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe 
    290                 295                 300                 


Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg 
305                 310                 315                 320 


Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser Thr 
                325                 330                 335     


Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu 
            340                 345                 350         


Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr Glu 
        355                 360                 365             


Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn Glu 
    370                 375                 380                 


Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp 
385                 390                 395                 400 


Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu 
                405                 410                 415     


Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu 
            420                 425                 430         


Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His 
        435                 440                 445             


Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Thr 
    450                 455                 460                 


Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu Asn 
465                 470                 475                 480 


Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu Arg 
                485                 490                 495     


Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly Leu 
            500                 505                 510         


His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Thr 
        515                 520                 525             


Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly Gln 
    530                 535                 540                 


Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly Asp 
545                 550                 555                 560 


Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys 
                565                 570                 575     


Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser 
            580                 585                 590         


Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys 
        595                 600                 605             


Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu Glu 
    610                 615                 620                 


Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu Gln 
625                 630                 635                 640 


Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn 
                645                 650                 655     


Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys 
            660                 665                 670         


Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Thr 
        675                 680                 685             


Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr Asn 
    690                 695                 700                 


Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys Glu 
705                 710                 715                 720 


Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu 
                725                 730                 735     


Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu 
            740                 745                 750         


Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser Ser 
        755                 760                 765             


Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile Ser 
    770                 775                 780                 


Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn Lys 
785                 790                 795                 800 


Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His 
                805                 810                 815     


Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr Pro 
            820                 825                 830         


Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met Glu 
        835                 840                 845             


Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val Ser 
    850                 855                 860                 


Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu Glu 
865                 870                 875                 880 


Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser 
                885                 890                 895     


Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys 
            900                 905                 910         


Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala Gly 
        915                 920                 925             


Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys 
    930                 935                 940                 


Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly 
945                 950                 955                 960 


Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln Asn 
                965                 970                 975     


Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys Thr 
            980                 985                 990         


Lys Cys Lys Lys Asn Leu Leu Glu  Glu Asn Phe Glu Glu  His Ser Met 
        995                 1000                 1005             


Ser Pro  Glu Arg Glu Met Gly  Asn Glu Asn Ile Pro  Ser Thr Val 
    1010                 1015                 1020             


Ser Thr  Ile Ser Arg Asn Asn  Ile Arg Glu Asn Val  Phe Lys Glu 
    1025                 1030                 1035             


Ala Ser  Ser Ser Asn Ile Asn  Glu Val Gly Ser Ser  Thr Asn Glu 
    1040                 1045                 1050             


Val Gly  Ser Ser Ile Asn Glu  Ile Gly Ser Ser Asp  Glu Asn Ile 
    1055                 1060                 1065             


Gln Ala  Glu Leu Gly Arg Asn  Arg Gly Pro Lys Leu  Asn Ala Met 
    1070                 1075                 1080             


Leu Arg  Leu Gly Val Leu Gln  Pro Glu Val Tyr Lys  Gln Ser Leu 
    1085                 1090                 1095             


Pro Gly  Ser Asn Cys Lys His  Pro Glu Ile Lys Lys  Gln Glu Tyr 
    1100                 1105                 1110             


Glu Glu  Val Val Gln Thr Val  Asn Thr Asp Phe Ser  Pro Tyr Leu 
    1115                 1120                 1125             


Ile Ser  Asp Asn Leu Glu Gln  Pro Met Gly Ser Ser  His Ala Ser 
    1130                 1135                 1140             


Gln Val  Cys Ser Glu Thr Pro  Asp Asp Leu Leu Asp  Asp Gly Glu 
    1145                 1150                 1155             


Ile Lys  Glu Asp Thr Ser Phe  Ala Glu Asn Asp Ile  Lys Glu Ser 
    1160                 1165                 1170             


Ser Ala  Val Phe Ser Lys Ser  Val Gln Lys Gly Glu  Leu Ser Arg 
    1175                 1180                 1185             


Ser Pro  Ser Pro Phe Thr His  Thr His Leu Ala Gln  Gly Tyr Arg 
    1190                 1195                 1200             


Arg Gly  Ala Lys Lys Leu Glu  Ser Ser Glu Glu Asn  Leu Ser Ser 
    1205                 1210                 1215             


Glu Asp  Glu Glu Leu Pro Cys  Phe Gln His Leu Leu  Phe Gly Lys 
    1220                 1225                 1230             


Val Asn  Asn Ile Pro Ser Gln  Ser Thr Arg His Ser  Thr Val Ala 
    1235                 1240                 1245             


Thr Glu  Cys Leu Ser Lys Asn  Thr Glu Glu Asn Leu  Leu Ser Leu 
    1250                 1255                 1260             


Lys Asn  Ser Leu Asn Asp Cys  Ser Asn Gln Val Ile  Leu Ala Lys 
    1265                 1270                 1275             


Ala Ser  Gln Glu His His Leu  Ser Glu Glu Thr Lys  Cys Ser Ala 
    1280                 1285                 1290             


Ser Leu  Phe Ser Ser Gln Cys  Ser Glu Leu Glu Asp  Leu Thr Ala 
    1295                 1300                 1305             


Asn Thr  Asn Thr Gln Asp Pro  Phe Leu Ile Gly Ser  Ser Lys Gln 
    1310                 1315                 1320             


Met Arg  His Gln Ser Glu Ser  Gln Gly Val Gly Leu  Ser Asp Lys 
    1325                 1330                 1335             


Glu Leu  Val Ser Asp Asp Glu  Glu Arg Gly Thr Gly  Leu Glu Glu 
    1340                 1345                 1350             


Asn Asn  Gln Glu Glu Gln Ser  Met Asp Ser Asn Leu  Gly Glu Ala 
    1355                 1360                 1365             


Ala Ser  Gly Cys Glu Ser Glu  Thr Ser Val Ser Glu  Asp Cys Ser 
    1370                 1375                 1380             


Gly Leu  Ser Ser Gln Ser Asp  Ile Leu Thr Thr Gln  Gln Arg Asp 
    1385                 1390                 1395             


Thr Met  Gln His Asn Leu Ile  Lys Leu Gln Gln Glu  Met Ala Glu 
    1400                 1405                 1410             


Leu Glu  Ala Val Leu Glu Gln  His Gly Ser Gln Pro  Ser Asn Ser 
    1415                 1420                 1425             


Tyr Pro  Ser Ile Ile Ser Asp  Ser Ser Ala Leu Glu  Asp Leu Arg 
    1430                 1435                 1440             


Asn Pro  Glu Gln Ser Thr Ser  Glu Lys Ala Val Leu  Thr Ser Gln 
    1445                 1450                 1455             


Lys Ser  Ser Glu Tyr Pro Ile  Ser Gln Asn Pro Glu  Gly Leu Ser 
    1460                 1465                 1470             


Ala Asp  Lys Phe Glu Val Ser  Ala Asp Ser Ser Thr  Ser Lys Asn 
    1475                 1480                 1485             


Lys Glu  Pro Gly Val Glu Arg  Ser Ser Pro Ser Lys  Cys Pro Ser 
    1490                 1495                 1500             


Leu Asp  Asp Arg Trp Tyr Met  His Ser Cys Ser Gly  Ser Leu Gln 
    1505                 1510                 1515             


Asn Arg  Asn Tyr Pro Ser Gln  Glu Glu Leu Ile Lys  Val Val Asp 
    1520                 1525                 1530             


Val Glu  Glu Gln Gln Leu Glu  Glu Ser Gly Pro His  Asp Leu Thr 
    1535                 1540                 1545             


Glu Thr  Ser Tyr Leu Pro Arg  Gln Asp Leu Glu Gly  Thr Pro Tyr 
    1550                 1555                 1560             


Leu Glu  Ser Gly Ile Ser Leu  Phe Ser Asp Asp Pro  Glu Ser Asp 
    1565                 1570                 1575             


Pro Ser  Glu Asp Arg Ala Pro  Glu Ser Ala Arg Val  Gly Asn Ile 
    1580                 1585                 1590             


Pro Ser  Ser Thr Ser Ala Leu  Lys Val Pro Gln Leu  Lys Val Ala 
    1595                 1600                 1605             


Glu Ser  Ala Gln Ser Pro Ala  Ala Ala His Thr Thr  Asp Thr Ala 
    1610                 1615                 1620             


Gly Tyr  Asn Ala Met Glu Glu  Ser Val Ser Arg Glu  Lys Pro Glu 
    1625                 1630                 1635             


Leu Thr  Ala Ser Thr Glu Arg  Val Asn Lys Arg Met  Ser Met Val 
    1640                 1645                 1650             


Val Ser  Gly Leu Thr Pro Glu  Glu Phe Met Leu Val  Tyr Lys Phe 
    1655                 1660                 1665             


Ala Arg  Lys His His Ile Thr  Leu Thr Asn Leu Ile  Thr Glu Glu 
    1670                 1675                 1680             


Thr Thr  His Val Val Met Lys  Thr Asp Ala Glu Phe  Val Cys Glu 
    1685                 1690                 1695             


Arg Thr  Leu Lys Tyr Phe Leu  Gly Ile Ala Gly Gly  Lys Trp Val 
    1700                 1705                 1710             


Val Ser  Tyr Phe Trp Val Thr  Gln Ser Ile Lys Glu  Arg Lys Met 
    1715                 1720                 1725             


Leu Asn  Glu His Asp Phe Glu  Val Arg Gly Asp Val  Val Asn Gly 
    1730                 1735                 1740             


Arg Asn  His Gln Gly Pro Lys  Arg Ala Arg Glu Ser  Gln Asp Arg 
    1745                 1750                 1755             


Lys Ile  Phe Arg Gly Leu Glu  Ile Cys Cys Tyr Gly  Pro Phe Thr 
    1760                 1765                 1770             


Asn Met  Pro Thr Asp Gln Leu  Glu Trp Met Val Gln  Leu Cys Gly 
    1775                 1780                 1785             


Ala Ser  Val Val Lys Glu Leu  Ser Ser Phe Thr Leu  Gly Thr Gly 
    1790                 1795                 1800             


Val His  Pro Ile Val Val Val  Gln Pro Asp Ala Trp  Thr Glu Asp 
    1805                 1810                 1815             


Asn Gly  Phe His Ala Ile Gly  Gln Met Cys Glu Ala  Pro Val Val 
    1820                 1825                 1830             


Thr Arg  Glu Trp Val Leu Asp  Ser Val Ala Leu Tyr  Gln Cys Gln 
    1835                 1840                 1845             


Glu Leu  Asp Thr Tyr Leu Ile  Pro Gln Ile Pro His  Ser His Tyr 
    1850                 1855                 1860             


<210>  3675
<211>  1816
<212>  PRT
<213>  Homo sapiens

<400>  3675

Met Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu 
1               5                   10                  15      


Cys Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe 
            20                  25                  30          


Ser Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu 
        35                  40                  45              


Asp Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu 
    50                  55                  60                  


Asn Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser 
65                  70                  75                  80  


Met Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu 
                85                  90                  95      


Asn Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu 
            100                 105                 110         


Gly Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys 
        115                 120                 125             


Thr Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val 
    130                 135                 140                 


Asn Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile 
145                 150                 155                 160 


Thr Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys 
                165                 170                 175     


Ala Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His 
            180                 185                 190         


Gln Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu 
        195                 200                 205             


Arg His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val 
    210                 215                 220                 


Glu Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn 
225                 230                 235                 240 


Ser Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu 
                245                 250                 255     


Phe Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn 
            260                 265                 270         


Arg Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser 
        275                 280                 285             


Thr Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys 
    290                 295                 300                 


Glu Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr 
305                 310                 315                 320 


Glu Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn 
                325                 330                 335     


Glu Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His 
            340                 345                 350         


Asp Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val 
        355                 360                 365             


Leu Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu 
    370                 375                 380                 


Leu Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val 
385                 390                 395                 400 


His Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys 
                405                 410                 415     


Thr Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu 
            420                 425                 430         


Asn Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu 
        435                 440                 445             


Arg Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly 
    450                 455                 460                 


Leu His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys 
465                 470                 475                 480 


Thr Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly 
                485                 490                 495     


Gln Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly 
            500                 505                 510         


Asp Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu 
        515                 520                 525             


Lys Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile 
    530                 535                 540                 


Ser Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys 
545                 550                 555                 560 


Lys Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu 
                565                 570                 575     


Glu Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu 
            580                 585                 590         


Gln Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr 
        595                 600                 605             


Asn Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly 
    610                 615                 620                 


Lys Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln 
625                 630                 635                 640 


Thr Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr 
                645                 650                 655     


Asn Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys 
            660                 665                 670         


Glu Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu 
        675                 680                 685             


Glu Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met 
    690                 695                 700                 


Leu Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser 
705                 710                 715                 720 


Ser Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile 
                725                 730                 735     


Ser Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn 
            740                 745                 750         


Lys Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile 
        755                 760                 765             


His Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr 
    770                 775                 780                 


Pro Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met 
785                 790                 795                 800 


Glu Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val 
                805                 810                 815     


Ser Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu 
            820                 825                 830         


Glu Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln 
        835                 840                 845             


Ser Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly 
    850                 855                 860                 


Lys Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala 
865                 870                 875                 880 


Gly Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys 
                885                 890                 895     


Cys Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg 
            900                 905                 910         


Gly Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln 
        915                 920                 925             


Asn Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys 
    930                 935                 940                 


Thr Lys Cys Lys Lys Asn Leu Leu Glu Glu Asn Phe Glu Glu His Ser 
945                 950                 955                 960 


Met Ser Pro Glu Arg Glu Met Gly Asn Glu Asn Ile Pro Ser Thr Val 
                965                 970                 975     


Ser Thr Ile Ser Arg Asn Asn Ile Arg Glu Asn Val Phe Lys Glu Ala 
            980                 985                 990         


Ser Ser Ser Asn Ile Asn Glu Val  Gly Ser Ser Thr Asn  Glu Val Gly 
        995                 1000                 1005             


Ser Ser  Ile Asn Glu Ile Gly  Ser Ser Asp Glu Asn  Ile Gln Ala 
    1010                 1015                 1020             


Glu Leu  Gly Arg Asn Arg Gly  Pro Lys Leu Asn Ala  Met Leu Arg 
    1025                 1030                 1035             


Leu Gly  Val Leu Gln Pro Glu  Val Tyr Lys Gln Ser  Leu Pro Gly 
    1040                 1045                 1050             


Ser Asn  Cys Lys His Pro Glu  Ile Lys Lys Gln Glu  Tyr Glu Glu 
    1055                 1060                 1065             


Val Val  Gln Thr Val Asn Thr  Asp Phe Ser Pro Tyr  Leu Ile Ser 
    1070                 1075                 1080             


Asp Asn  Leu Glu Gln Pro Met  Gly Ser Ser His Ala  Ser Gln Val 
    1085                 1090                 1095             


Cys Ser  Glu Thr Pro Asp Asp  Leu Leu Asp Asp Gly  Glu Ile Lys 
    1100                 1105                 1110             


Glu Asp  Thr Ser Phe Ala Glu  Asn Asp Ile Lys Glu  Ser Ser Ala 
    1115                 1120                 1125             


Val Phe  Ser Lys Ser Val Gln  Lys Gly Glu Leu Ser  Arg Ser Pro 
    1130                 1135                 1140             


Ser Pro  Phe Thr His Thr His  Leu Ala Gln Gly Tyr  Arg Arg Gly 
    1145                 1150                 1155             


Ala Lys  Lys Leu Glu Ser Ser  Glu Glu Asn Leu Ser  Ser Glu Asp 
    1160                 1165                 1170             


Glu Glu  Leu Pro Cys Phe Gln  His Leu Leu Phe Gly  Lys Val Asn 
    1175                 1180                 1185             


Asn Ile  Pro Ser Gln Ser Thr  Arg His Ser Thr Val  Ala Thr Glu 
    1190                 1195                 1200             


Cys Leu  Ser Lys Asn Thr Glu  Glu Asn Leu Leu Ser  Leu Lys Asn 
    1205                 1210                 1215             


Ser Leu  Asn Asp Cys Ser Asn  Gln Val Ile Leu Ala  Lys Ala Ser 
    1220                 1225                 1230             


Gln Glu  His His Leu Ser Glu  Glu Thr Lys Cys Ser  Ala Ser Leu 
    1235                 1240                 1245             


Phe Ser  Ser Gln Cys Ser Glu  Leu Glu Asp Leu Thr  Ala Asn Thr 
    1250                 1255                 1260             


Asn Thr  Gln Asp Pro Phe Leu  Ile Gly Ser Ser Lys  Gln Met Arg 
    1265                 1270                 1275             


His Gln  Ser Glu Ser Gln Gly  Val Gly Leu Ser Asp  Lys Glu Leu 
    1280                 1285                 1290             


Val Ser  Asp Asp Glu Glu Arg  Gly Thr Gly Leu Glu  Glu Asn Asn 
    1295                 1300                 1305             


Gln Glu  Glu Gln Ser Met Asp  Ser Asn Leu Gly Glu  Ala Ala Ser 
    1310                 1315                 1320             


Gly Cys  Glu Ser Glu Thr Ser  Val Ser Glu Asp Cys  Ser Gly Leu 
    1325                 1330                 1335             


Ser Ser  Gln Ser Asp Ile Leu  Thr Thr Gln Gln Arg  Asp Thr Met 
    1340                 1345                 1350             


Gln His  Asn Leu Ile Lys Leu  Gln Gln Glu Met Ala  Glu Leu Glu 
    1355                 1360                 1365             


Ala Val  Leu Glu Gln His Gly  Ser Gln Pro Ser Asn  Ser Tyr Pro 
    1370                 1375                 1380             


Ser Ile  Ile Ser Asp Ser Ser  Ala Leu Glu Asp Leu  Arg Asn Pro 
    1385                 1390                 1395             


Glu Gln  Ser Thr Ser Glu Lys  Ala Val Leu Thr Ser  Gln Lys Ser 
    1400                 1405                 1410             


Ser Glu  Tyr Pro Ile Ser Gln  Asn Pro Glu Gly Leu  Ser Ala Asp 
    1415                 1420                 1425             


Lys Phe  Glu Val Ser Ala Asp  Ser Ser Thr Ser Lys  Asn Lys Glu 
    1430                 1435                 1440             


Pro Gly  Val Glu Arg Ser Ser  Pro Ser Lys Cys Pro  Ser Leu Asp 
    1445                 1450                 1455             


Asp Arg  Trp Tyr Met His Ser  Cys Ser Gly Ser Leu  Gln Asn Arg 
    1460                 1465                 1470             


Asn Tyr  Pro Ser Gln Glu Glu  Leu Ile Lys Val Val  Asp Val Glu 
    1475                 1480                 1485             


Glu Gln  Gln Leu Glu Glu Ser  Gly Pro His Asp Leu  Thr Glu Thr 
    1490                 1495                 1500             


Ser Tyr  Leu Pro Arg Gln Asp  Leu Glu Gly Thr Pro  Tyr Leu Glu 
    1505                 1510                 1515             


Ser Gly  Ile Ser Leu Phe Ser  Asp Asp Pro Glu Ser  Asp Pro Ser 
    1520                 1525                 1530             


Glu Asp  Arg Ala Pro Glu Ser  Ala Arg Val Gly Asn  Ile Pro Ser 
    1535                 1540                 1545             


Ser Thr  Ser Ala Leu Lys Val  Pro Gln Leu Lys Val  Ala Glu Ser 
    1550                 1555                 1560             


Ala Gln  Ser Pro Ala Ala Ala  His Thr Thr Asp Thr  Ala Gly Tyr 
    1565                 1570                 1575             


Asn Ala  Met Glu Glu Ser Val  Ser Arg Glu Lys Pro  Glu Leu Thr 
    1580                 1585                 1590             


Ala Ser  Thr Glu Arg Val Asn  Lys Arg Met Ser Met  Val Val Ser 
    1595                 1600                 1605             


Gly Leu  Thr Pro Glu Glu Phe  Met Leu Val Tyr Lys  Phe Ala Arg 
    1610                 1615                 1620             


Lys His  His Ile Thr Leu Thr  Asn Leu Ile Thr Glu  Glu Thr Thr 
    1625                 1630                 1635             


His Val  Val Met Lys Thr Asp  Ala Glu Phe Val Cys  Glu Arg Thr 
    1640                 1645                 1650             


Leu Lys  Tyr Phe Leu Gly Ile  Ala Gly Gly Lys Trp  Val Val Ser 
    1655                 1660                 1665             


Tyr Phe  Trp Val Thr Gln Ser  Ile Lys Glu Arg Lys  Met Leu Asn 
    1670                 1675                 1680             


Glu His  Asp Phe Glu Val Arg  Gly Asp Val Val Asn  Gly Arg Asn 
    1685                 1690                 1695             


His Gln  Gly Pro Lys Arg Ala  Arg Glu Ser Gln Asp  Arg Lys Ile 
    1700                 1705                 1710             


Phe Arg  Gly Leu Glu Ile Cys  Cys Tyr Gly Pro Phe  Thr Asn Met 
    1715                 1720                 1725             


Pro Thr  Asp Gln Leu Glu Trp  Met Val Gln Leu Cys  Gly Ala Ser 
    1730                 1735                 1740             


Val Val  Lys Glu Leu Ser Ser  Phe Thr Leu Gly Thr  Gly Val His 
    1745                 1750                 1755             


Pro Ile  Val Val Val Gln Pro  Asp Ala Trp Thr Glu  Asp Asn Gly 
    1760                 1765                 1770             


Phe His  Ala Ile Gly Gln Met  Cys Glu Ala Pro Val  Val Thr Arg 
    1775                 1780                 1785             


Glu Trp  Val Leu Asp Ser Val  Ala Leu Tyr Gln Cys  Gln Glu Leu 
    1790                 1795                 1800             


Asp Thr  Tyr Leu Ile Pro Gln  Ile Pro His Ser His  Tyr 
    1805                 1810                 1815     


<210>  3676
<211>  759
<212>  PRT
<213>  Homo sapiens

<400>  3676

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 
            180                 185                 190         


Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 
        195                 200                 205             


Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Glu Ala Ala Ser Gly Cys Glu Ser Glu 
            260                 265                 270         


Thr Ser Val Ser Glu Asp Cys Ser Gly Leu Ser Ser Gln Ser Asp Ile 
        275                 280                 285             


Leu Thr Thr Gln Gln Arg Asp Thr Met Gln His Asn Leu Ile Lys Leu 
    290                 295                 300                 


Gln Gln Glu Met Ala Glu Leu Glu Ala Val Leu Glu Gln His Gly Ser 
305                 310                 315                 320 


Gln Pro Ser Asn Ser Tyr Pro Ser Ile Ile Ser Asp Ser Ser Ala Leu 
                325                 330                 335     


Glu Asp Leu Arg Asn Pro Glu Gln Ser Thr Ser Glu Lys Val Leu Thr 
            340                 345                 350         


Ser Gln Lys Ser Ser Glu Tyr Pro Ile Ser Gln Asn Pro Glu Gly Leu 
        355                 360                 365             


Ser Ala Asp Lys Phe Glu Val Ser Ala Asp Ser Ser Thr Ser Lys Asn 
    370                 375                 380                 


Lys Glu Pro Gly Val Glu Arg Ser Ser Pro Ser Lys Cys Pro Ser Leu 
385                 390                 395                 400 


Asp Asp Arg Trp Tyr Met His Ser Cys Ser Gly Ser Leu Gln Asn Arg 
                405                 410                 415     


Asn Tyr Pro Ser Gln Glu Glu Leu Ile Lys Val Val Asp Val Glu Glu 
            420                 425                 430         


Gln Gln Leu Glu Glu Ser Gly Pro His Asp Leu Thr Glu Thr Ser Tyr 
        435                 440                 445             


Leu Pro Arg Gln Asp Leu Glu Gly Thr Pro Tyr Leu Glu Ser Gly Ile 
    450                 455                 460                 


Ser Leu Phe Ser Asp Asp Pro Glu Ser Asp Pro Ser Glu Asp Arg Ala 
465                 470                 475                 480 


Pro Glu Ser Ala Arg Val Gly Asn Ile Pro Ser Ser Thr Ser Ala Leu 
                485                 490                 495     


Lys Val Pro Gln Leu Lys Val Ala Glu Ser Ala Gln Ser Pro Ala Ala 
            500                 505                 510         


Ala His Thr Thr Asp Thr Ala Gly Tyr Asn Ala Met Glu Glu Ser Val 
        515                 520                 525             


Ser Arg Glu Lys Pro Glu Leu Thr Ala Ser Thr Glu Arg Val Asn Lys 
    530                 535                 540                 


Arg Met Ser Met Val Val Ser Gly Leu Thr Pro Glu Glu Phe Met Leu 
545                 550                 555                 560 


Val Tyr Lys Phe Ala Arg Lys His His Ile Thr Leu Thr Asn Leu Ile 
                565                 570                 575     


Thr Glu Glu Thr Thr His Val Val Met Lys Thr Asp Ala Glu Phe Val 
            580                 585                 590         


Cys Glu Arg Thr Leu Lys Tyr Phe Leu Gly Ile Ala Gly Gly Lys Trp 
        595                 600                 605             


Val Val Ser Tyr Phe Trp Val Thr Gln Ser Ile Lys Glu Arg Lys Met 
    610                 615                 620                 


Leu Asn Glu His Asp Phe Glu Val Arg Gly Asp Val Val Asn Gly Arg 
625                 630                 635                 640 


Asn His Gln Gly Pro Lys Arg Ala Arg Glu Ser Gln Asp Arg Lys Ile 
                645                 650                 655     


Phe Arg Gly Leu Glu Ile Cys Cys Tyr Gly Pro Phe Thr Asn Met Pro 
            660                 665                 670         


Thr Asp Gln Leu Glu Trp Met Val Gln Leu Cys Gly Ala Ser Val Val 
        675                 680                 685             


Lys Glu Leu Ser Ser Phe Thr Leu Gly Thr Gly Val His Pro Ile Val 
    690                 695                 700                 


Val Val Gln Pro Asp Ala Trp Thr Glu Asp Asn Gly Phe His Ala Ile 
705                 710                 715                 720 


Gly Gln Met Cys Glu Ala Pro Val Val Thr Arg Glu Trp Val Leu Asp 
                725                 730                 735     


Ser Val Ala Leu Tyr Gln Cys Gln Glu Leu Asp Thr Tyr Leu Ile Pro 
            740                 745                 750         


Gln Ile Pro His Ser His Tyr 
        755                 


<210>  3677
<211>  699
<212>  PRT
<213>  Homo sapiens

<400>  3677

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 
            180                 185                 190         


Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 
        195                 200                 205             


Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Glu Ala Ala Ser Gly Cys Glu Ser Glu 
            260                 265                 270         


Thr Ser Val Ser Glu Asp Cys Ser Gly Leu Ser Ser Gln Ser Asp Ile 
        275                 280                 285             


Leu Thr Thr Gln Gln Arg Asp Thr Met Gln His Asn Leu Ile Lys Leu 
    290                 295                 300                 


Gln Gln Glu Met Ala Glu Leu Glu Ala Val Leu Glu Gln His Gly Ser 
305                 310                 315                 320 


Gln Pro Ser Asn Ser Tyr Pro Ser Ile Ile Ser Asp Ser Ser Ala Leu 
                325                 330                 335     


Glu Asp Leu Arg Asn Pro Glu Gln Ser Thr Ser Glu Lys Val Leu Thr 
            340                 345                 350         


Ser Gln Lys Ser Ser Glu Tyr Pro Ile Ser Gln Asn Pro Glu Gly Leu 
        355                 360                 365             


Ser Ala Asp Lys Phe Glu Val Ser Ala Asp Ser Ser Thr Ser Lys Asn 
    370                 375                 380                 


Lys Glu Pro Gly Val Glu Arg Ser Ser Pro Ser Lys Cys Pro Ser Leu 
385                 390                 395                 400 


Asp Asp Arg Trp Tyr Met His Ser Cys Ser Gly Ser Leu Gln Asn Arg 
                405                 410                 415     


Asn Tyr Pro Ser Gln Glu Glu Leu Ile Lys Val Val Asp Val Glu Glu 
            420                 425                 430         


Gln Gln Leu Glu Glu Ser Gly Pro His Asp Leu Thr Glu Thr Ser Tyr 
        435                 440                 445             


Leu Pro Arg Gln Asp Leu Glu Gly Thr Pro Tyr Leu Glu Ser Gly Ile 
    450                 455                 460                 


Ser Leu Phe Ser Asp Asp Pro Glu Ser Asp Pro Ser Glu Asp Arg Ala 
465                 470                 475                 480 


Pro Glu Ser Ala Arg Val Gly Asn Ile Pro Ser Ser Thr Ser Ala Leu 
                485                 490                 495     


Lys Val Pro Gln Leu Lys Val Ala Glu Ser Ala Gln Ser Pro Ala Ala 
            500                 505                 510         


Ala His Thr Thr Asp Thr Ala Gly Tyr Asn Ala Met Glu Glu Ser Val 
        515                 520                 525             


Ser Arg Glu Lys Pro Glu Leu Thr Ala Ser Thr Glu Arg Val Asn Lys 
    530                 535                 540                 


Arg Met Ser Met Val Val Ser Gly Leu Thr Pro Glu Glu Phe Met Leu 
545                 550                 555                 560 


Val Tyr Lys Phe Ala Arg Lys His His Ile Thr Leu Thr Asn Leu Ile 
                565                 570                 575     


Thr Glu Glu Thr Thr His Val Val Met Lys Thr Asp Ala Glu Phe Val 
            580                 585                 590         


Cys Glu Arg Thr Leu Lys Tyr Phe Leu Gly Ile Ala Gly Gly Lys Trp 
        595                 600                 605             


Val Val Ser Tyr Phe Trp Val Thr Gln Ser Ile Lys Glu Arg Lys Met 
    610                 615                 620                 


Leu Asn Glu His Asp Phe Glu Val Arg Gly Asp Val Val Asn Gly Arg 
625                 630                 635                 640 


Asn His Gln Gly Pro Lys Arg Ala Arg Glu Ser Gln Asp Arg Lys Ile 
                645                 650                 655     


Phe Arg Gly Leu Glu Ile Cys Cys Tyr Gly Pro Phe Thr Asn Met Pro 
            660                 665                 670         


Thr Gly Cys Pro Pro Asn Cys Gly Cys Ala Ala Arg Cys Leu Asp Arg 
        675                 680                 685             


Gly Gln Trp Leu Pro Cys Asn Trp Ala Asp Val 
    690                 695                 


<210>  3678
<211>  1884
<212>  PRT
<213>  Homo sapiens

<400>  3678

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 
            180                 185                 190         


Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 
        195                 200                 205             


Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu 
            260                 265                 270         


Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn Ser 
        275                 280                 285             


Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe 
    290                 295                 300                 


Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg 
305                 310                 315                 320 


Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser Thr 
                325                 330                 335     


Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu 
            340                 345                 350         


Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr Glu 
        355                 360                 365             


Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn Glu 
    370                 375                 380                 


Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp 
385                 390                 395                 400 


Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu 
                405                 410                 415     


Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu 
            420                 425                 430         


Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His 
        435                 440                 445             


Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Thr 
    450                 455                 460                 


Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu Asn 
465                 470                 475                 480 


Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu Arg 
                485                 490                 495     


Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly Leu 
            500                 505                 510         


His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Thr 
        515                 520                 525             


Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly Gln 
    530                 535                 540                 


Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly Asp 
545                 550                 555                 560 


Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys 
                565                 570                 575     


Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser 
            580                 585                 590         


Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys 
        595                 600                 605             


Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu Glu 
    610                 615                 620                 


Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu Gln 
625                 630                 635                 640 


Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn 
                645                 650                 655     


Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys 
            660                 665                 670         


Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Thr 
        675                 680                 685             


Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr Asn 
    690                 695                 700                 


Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys Glu 
705                 710                 715                 720 


Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu 
                725                 730                 735     


Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu 
            740                 745                 750         


Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser Ser 
        755                 760                 765             


Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile Ser 
    770                 775                 780                 


Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn Lys 
785                 790                 795                 800 


Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His 
                805                 810                 815     


Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr Pro 
            820                 825                 830         


Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met Glu 
        835                 840                 845             


Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val Ser 
    850                 855                 860                 


Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu Glu 
865                 870                 875                 880 


Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser 
                885                 890                 895     


Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys 
            900                 905                 910         


Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala Gly 
        915                 920                 925             


Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys 
    930                 935                 940                 


Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly 
945                 950                 955                 960 


Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln Asn 
                965                 970                 975     


Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys Thr 
            980                 985                 990         


Lys Cys Lys Lys Asn Leu Leu Glu  Glu Asn Phe Glu Glu  His Ser Met 
        995                 1000                 1005             


Ser Pro  Glu Arg Glu Met Gly  Asn Glu Asn Ile Pro  Ser Thr Val 
    1010                 1015                 1020             


Ser Thr  Ile Ser Arg Asn Asn  Ile Arg Glu Asn Val  Phe Lys Glu 
    1025                 1030                 1035             


Ala Ser  Ser Ser Asn Ile Asn  Glu Val Gly Ser Ser  Thr Asn Glu 
    1040                 1045                 1050             


Val Gly  Ser Ser Ile Asn Glu  Ile Gly Ser Ser Asp  Glu Asn Ile 
    1055                 1060                 1065             


Gln Ala  Glu Leu Gly Arg Asn  Arg Gly Pro Lys Leu  Asn Ala Met 
    1070                 1075                 1080             


Leu Arg  Leu Gly Val Leu Gln  Pro Glu Val Tyr Lys  Gln Ser Leu 
    1085                 1090                 1095             


Pro Gly  Ser Asn Cys Lys His  Pro Glu Ile Lys Lys  Gln Glu Tyr 
    1100                 1105                 1110             


Glu Glu  Val Val Gln Thr Val  Asn Thr Asp Phe Ser  Pro Tyr Leu 
    1115                 1120                 1125             


Ile Ser  Asp Asn Leu Glu Gln  Pro Met Gly Ser Ser  His Ala Ser 
    1130                 1135                 1140             


Gln Val  Cys Ser Glu Thr Pro  Asp Asp Leu Leu Asp  Asp Gly Glu 
    1145                 1150                 1155             


Ile Lys  Glu Asp Thr Ser Phe  Ala Glu Asn Asp Ile  Lys Glu Ser 
    1160                 1165                 1170             


Ser Ala  Val Phe Ser Lys Ser  Val Gln Lys Gly Glu  Leu Ser Arg 
    1175                 1180                 1185             


Ser Pro  Ser Pro Phe Thr His  Thr His Leu Ala Gln  Gly Tyr Arg 
    1190                 1195                 1200             


Arg Gly  Ala Lys Lys Leu Glu  Ser Ser Glu Glu Asn  Leu Ser Ser 
    1205                 1210                 1215             


Glu Asp  Glu Glu Leu Pro Cys  Phe Gln His Leu Leu  Phe Gly Lys 
    1220                 1225                 1230             


Val Asn  Asn Ile Pro Ser Gln  Ser Thr Arg His Ser  Thr Val Ala 
    1235                 1240                 1245             


Thr Glu  Cys Leu Ser Lys Asn  Thr Glu Glu Asn Leu  Leu Ser Leu 
    1250                 1255                 1260             


Lys Asn  Ser Leu Asn Asp Cys  Ser Asn Gln Val Ile  Leu Ala Lys 
    1265                 1270                 1275             


Ala Ser  Gln Glu His His Leu  Ser Glu Glu Thr Lys  Cys Ser Ala 
    1280                 1285                 1290             


Ser Leu  Phe Ser Ser Gln Cys  Ser Glu Leu Glu Asp  Leu Thr Ala 
    1295                 1300                 1305             


Asn Thr  Asn Thr Gln Asp Pro  Phe Leu Ile Gly Ser  Ser Lys Gln 
    1310                 1315                 1320             


Met Arg  His Gln Ser Glu Ser  Gln Gly Val Gly Leu  Ser Asp Lys 
    1325                 1330                 1335             


Glu Leu  Val Ser Asp Asp Glu  Glu Arg Gly Thr Gly  Leu Glu Glu 
    1340                 1345                 1350             


Asn Asn  Gln Glu Glu Gln Ser  Met Asp Ser Asn Leu  Gly Glu Ala 
    1355                 1360                 1365             


Ala Ser  Gly Cys Glu Ser Glu  Thr Ser Val Ser Glu  Asp Cys Ser 
    1370                 1375                 1380             


Gly Leu  Ser Ser Gln Ser Asp  Ile Leu Thr Thr Gln  Gln Arg Asp 
    1385                 1390                 1395             


Thr Met  Gln His Asn Leu Ile  Lys Leu Gln Gln Glu  Met Ala Glu 
    1400                 1405                 1410             


Leu Glu  Ala Val Leu Glu Gln  His Gly Ser Gln Pro  Ser Asn Ser 
    1415                 1420                 1425             


Tyr Pro  Ser Ile Ile Ser Asp  Ser Ser Ala Leu Glu  Asp Leu Arg 
    1430                 1435                 1440             


Asn Pro  Glu Gln Ser Thr Ser  Glu Lys Asp Ser His  Ile His Gly 
    1445                 1450                 1455             


Gln Arg  Asn Asn Ser Met Phe  Ser Lys Arg Pro Arg  Glu His Ile 
    1460                 1465                 1470             


Ser Val  Leu Thr Ser Gln Lys  Ser Ser Glu Tyr Pro  Ile Ser Gln 
    1475                 1480                 1485             


Asn Pro  Glu Gly Leu Ser Ala  Asp Lys Phe Glu Val  Ser Ala Asp 
    1490                 1495                 1500             


Ser Ser  Thr Ser Lys Asn Lys  Glu Pro Gly Val Glu  Arg Ser Ser 
    1505                 1510                 1515             


Pro Ser  Lys Cys Pro Ser Leu  Asp Asp Arg Trp Tyr  Met His Ser 
    1520                 1525                 1530             


Cys Ser  Gly Ser Leu Gln Asn  Arg Asn Tyr Pro Ser  Gln Glu Glu 
    1535                 1540                 1545             


Leu Ile  Lys Val Val Asp Val  Glu Glu Gln Gln Leu  Glu Glu Ser 
    1550                 1555                 1560             


Gly Pro  His Asp Leu Thr Glu  Thr Ser Tyr Leu Pro  Arg Gln Asp 
    1565                 1570                 1575             


Leu Glu  Gly Thr Pro Tyr Leu  Glu Ser Gly Ile Ser  Leu Phe Ser 
    1580                 1585                 1590             


Asp Asp  Pro Glu Ser Asp Pro  Ser Glu Asp Arg Ala  Pro Glu Ser 
    1595                 1600                 1605             


Ala Arg  Val Gly Asn Ile Pro  Ser Ser Thr Ser Ala  Leu Lys Val 
    1610                 1615                 1620             


Pro Gln  Leu Lys Val Ala Glu  Ser Ala Gln Ser Pro  Ala Ala Ala 
    1625                 1630                 1635             


His Thr  Thr Asp Thr Ala Gly  Tyr Asn Ala Met Glu  Glu Ser Val 
    1640                 1645                 1650             


Ser Arg  Glu Lys Pro Glu Leu  Thr Ala Ser Thr Glu  Arg Val Asn 
    1655                 1660                 1665             


Lys Arg  Met Ser Met Val Val  Ser Gly Leu Thr Pro  Glu Glu Phe 
    1670                 1675                 1680             


Met Leu  Val Tyr Lys Phe Ala  Arg Lys His His Ile  Thr Leu Thr 
    1685                 1690                 1695             


Asn Leu  Ile Thr Glu Glu Thr  Thr His Val Val Met  Lys Thr Asp 
    1700                 1705                 1710             


Ala Glu  Phe Val Cys Glu Arg  Thr Leu Lys Tyr Phe  Leu Gly Ile 
    1715                 1720                 1725             


Ala Gly  Gly Lys Trp Val Val  Ser Tyr Phe Trp Val  Thr Gln Ser 
    1730                 1735                 1740             


Ile Lys  Glu Arg Lys Met Leu  Asn Glu His Asp Phe  Glu Val Arg 
    1745                 1750                 1755             


Gly Asp  Val Val Asn Gly Arg  Asn His Gln Gly Pro  Lys Arg Ala 
    1760                 1765                 1770             


Arg Glu  Ser Gln Asp Arg Lys  Ile Phe Arg Gly Leu  Glu Ile Cys 
    1775                 1780                 1785             


Cys Tyr  Gly Pro Phe Thr Asn  Met Pro Thr Asp Gln  Leu Glu Trp 
    1790                 1795                 1800             


Met Val  Gln Leu Cys Gly Ala  Ser Val Val Lys Glu  Leu Ser Ser 
    1805                 1810                 1815             


Phe Thr  Leu Gly Thr Gly Val  His Pro Ile Val Val  Val Gln Pro 
    1820                 1825                 1830             


Asp Ala  Trp Thr Glu Asp Asn  Gly Phe His Ala Ile  Gly Gln Met 
    1835                 1840                 1845             


Cys Glu  Ala Pro Val Val Thr  Arg Glu Trp Val Leu  Asp Ser Val 
    1850                 1855                 1860             


Ala Leu  Tyr Gln Cys Gln Glu  Leu Asp Thr Tyr Leu  Ile Pro Gln 
    1865                 1870                 1875             


Ile Pro  His Ser His Tyr 
    1880                 


<210>  3679
<211>  1863
<212>  PRT
<213>  Homo sapiens

<400>  3679

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 
            180                 185                 190         


Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 
        195                 200                 205             


Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu 
            260                 265                 270         


Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn Ser 
        275                 280                 285             


Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe 
    290                 295                 300                 


Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg 
305                 310                 315                 320 


Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser Thr 
                325                 330                 335     


Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu 
            340                 345                 350         


Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr Glu 
        355                 360                 365             


Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn Glu 
    370                 375                 380                 


Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp 
385                 390                 395                 400 


Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu 
                405                 410                 415     


Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu 
            420                 425                 430         


Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His 
        435                 440                 445             


Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Thr 
    450                 455                 460                 


Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu Asn 
465                 470                 475                 480 


Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu Arg 
                485                 490                 495     


Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly Leu 
            500                 505                 510         


His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Thr 
        515                 520                 525             


Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly Gln 
    530                 535                 540                 


Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly Asp 
545                 550                 555                 560 


Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys 
                565                 570                 575     


Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser 
            580                 585                 590         


Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys 
        595                 600                 605             


Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu Glu 
    610                 615                 620                 


Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu Gln 
625                 630                 635                 640 


Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn 
                645                 650                 655     


Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys 
            660                 665                 670         


Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Thr 
        675                 680                 685             


Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr Asn 
    690                 695                 700                 


Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys Glu 
705                 710                 715                 720 


Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu 
                725                 730                 735     


Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu 
            740                 745                 750         


Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser Ser 
        755                 760                 765             


Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile Ser 
    770                 775                 780                 


Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn Lys 
785                 790                 795                 800 


Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His 
                805                 810                 815     


Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr Pro 
            820                 825                 830         


Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met Glu 
        835                 840                 845             


Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val Ser 
    850                 855                 860                 


Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu Glu 
865                 870                 875                 880 


Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser 
                885                 890                 895     


Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys 
            900                 905                 910         


Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala Gly 
        915                 920                 925             


Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys 
    930                 935                 940                 


Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly 
945                 950                 955                 960 


Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln Asn 
                965                 970                 975     


Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys Thr 
            980                 985                 990         


Lys Cys Lys Lys Asn Leu Leu Glu  Glu Asn Phe Glu Glu  His Ser Met 
        995                 1000                 1005             


Ser Pro  Glu Arg Glu Met Gly  Asn Glu Asn Ile Pro  Ser Thr Val 
    1010                 1015                 1020             


Ser Thr  Ile Ser Arg Asn Asn  Ile Arg Glu Asn Val  Phe Lys Glu 
    1025                 1030                 1035             


Ala Ser  Ser Ser Asn Ile Asn  Glu Val Gly Ser Ser  Thr Asn Glu 
    1040                 1045                 1050             


Val Gly  Ser Ser Ile Asn Glu  Ile Gly Ser Ser Asp  Glu Asn Ile 
    1055                 1060                 1065             


Gln Ala  Glu Leu Gly Arg Asn  Arg Gly Pro Lys Leu  Asn Ala Met 
    1070                 1075                 1080             


Leu Arg  Leu Gly Val Leu Gln  Pro Glu Val Tyr Lys  Gln Ser Leu 
    1085                 1090                 1095             


Pro Gly  Ser Asn Cys Lys His  Pro Glu Ile Lys Lys  Gln Glu Tyr 
    1100                 1105                 1110             


Glu Glu  Val Val Gln Thr Val  Asn Thr Asp Phe Ser  Pro Tyr Leu 
    1115                 1120                 1125             


Ile Ser  Asp Asn Leu Glu Gln  Pro Met Gly Ser Ser  His Ala Ser 
    1130                 1135                 1140             


Gln Val  Cys Ser Glu Thr Pro  Asp Asp Leu Leu Asp  Asp Gly Glu 
    1145                 1150                 1155             


Ile Lys  Glu Asp Thr Ser Phe  Ala Glu Asn Asp Ile  Lys Glu Ser 
    1160                 1165                 1170             


Ser Ala  Val Phe Ser Lys Ser  Val Gln Lys Gly Glu  Leu Ser Arg 
    1175                 1180                 1185             


Ser Pro  Ser Pro Phe Thr His  Thr His Leu Ala Gln  Gly Tyr Arg 
    1190                 1195                 1200             


Arg Gly  Ala Lys Lys Leu Glu  Ser Ser Glu Glu Asn  Leu Ser Ser 
    1205                 1210                 1215             


Glu Asp  Glu Glu Leu Pro Cys  Phe Gln His Leu Leu  Phe Gly Lys 
    1220                 1225                 1230             


Val Asn  Asn Ile Pro Ser Gln  Ser Thr Arg His Ser  Thr Val Ala 
    1235                 1240                 1245             


Thr Glu  Cys Leu Ser Lys Asn  Thr Glu Glu Asn Leu  Leu Ser Leu 
    1250                 1255                 1260             


Lys Asn  Ser Leu Asn Asp Cys  Ser Asn Gln Val Ile  Leu Ala Lys 
    1265                 1270                 1275             


Ala Ser  Gln Glu His His Leu  Ser Glu Glu Thr Lys  Cys Ser Ala 
    1280                 1285                 1290             


Ser Leu  Phe Ser Ser Gln Cys  Ser Glu Leu Glu Asp  Leu Thr Ala 
    1295                 1300                 1305             


Asn Thr  Asn Thr Gln Asp Pro  Phe Leu Ile Gly Ser  Ser Lys Gln 
    1310                 1315                 1320             


Met Arg  His Gln Ser Glu Ser  Gln Gly Val Gly Leu  Ser Asp Lys 
    1325                 1330                 1335             


Glu Leu  Val Ser Asp Asp Glu  Glu Arg Gly Thr Gly  Leu Glu Glu 
    1340                 1345                 1350             


Asn Asn  Gln Glu Glu Gln Ser  Met Asp Ser Asn Leu  Gly Glu Ala 
    1355                 1360                 1365             


Ala Ser  Gly Cys Glu Ser Glu  Thr Ser Val Ser Glu  Asp Cys Ser 
    1370                 1375                 1380             


Gly Leu  Ser Ser Gln Ser Asp  Ile Leu Thr Thr Gln  Gln Arg Asp 
    1385                 1390                 1395             


Thr Met  Gln His Asn Leu Ile  Lys Leu Gln Gln Glu  Met Ala Glu 
    1400                 1405                 1410             


Leu Glu  Ala Val Leu Glu Gln  His Gly Ser Gln Pro  Ser Asn Ser 
    1415                 1420                 1425             


Tyr Pro  Ser Ile Ile Ser Asp  Ser Ser Ala Leu Glu  Asp Leu Arg 
    1430                 1435                 1440             


Asn Pro  Glu Gln Ser Thr Ser  Glu Lys Ala Val Leu  Thr Ser Gln 
    1445                 1450                 1455             


Lys Ser  Ser Glu Tyr Pro Ile  Ser Gln Asn Pro Glu  Gly Leu Ser 
    1460                 1465                 1470             


Ala Asp  Lys Phe Glu Val Ser  Ala Asp Ser Ser Thr  Ser Lys Asn 
    1475                 1480                 1485             


Lys Glu  Pro Gly Val Glu Arg  Ser Ser Pro Ser Lys  Cys Pro Ser 
    1490                 1495                 1500             


Leu Asp  Asp Arg Trp Tyr Met  His Ser Cys Ser Gly  Ser Leu Gln 
    1505                 1510                 1515             


Asn Arg  Asn Tyr Pro Ser Gln  Glu Glu Leu Ile Lys  Val Val Asp 
    1520                 1525                 1530             


Val Glu  Glu Gln Gln Leu Glu  Glu Ser Gly Pro His  Asp Leu Thr 
    1535                 1540                 1545             


Glu Thr  Ser Tyr Leu Pro Arg  Gln Asp Leu Glu Gly  Thr Pro Tyr 
    1550                 1555                 1560             


Leu Glu  Ser Gly Ile Ser Leu  Phe Ser Asp Asp Pro  Glu Ser Asp 
    1565                 1570                 1575             


Pro Ser  Glu Asp Arg Ala Pro  Glu Ser Ala Arg Val  Gly Asn Ile 
    1580                 1585                 1590             


Pro Ser  Ser Thr Ser Ala Leu  Lys Val Pro Gln Leu  Lys Val Ala 
    1595                 1600                 1605             


Glu Ser  Ala Gln Ser Pro Ala  Ala Ala His Thr Thr  Asp Thr Ala 
    1610                 1615                 1620             


Gly Tyr  Asn Ala Met Glu Glu  Ser Val Ser Arg Glu  Lys Pro Glu 
    1625                 1630                 1635             


Leu Thr  Ala Ser Thr Glu Arg  Val Asn Lys Arg Met  Ser Met Val 
    1640                 1645                 1650             


Val Ser  Gly Leu Thr Pro Glu  Glu Phe Met Leu Val  Tyr Lys Phe 
    1655                 1660                 1665             


Ala Arg  Lys His His Ile Thr  Leu Thr Asn Leu Ile  Thr Glu Glu 
    1670                 1675                 1680             


Thr Thr  His Val Val Met Lys  Thr Asp Ala Glu Phe  Val Cys Glu 
    1685                 1690                 1695             


Arg Thr  Leu Lys Tyr Phe Leu  Gly Ile Ala Gly Gly  Lys Trp Val 
    1700                 1705                 1710             


Val Ser  Tyr Phe Trp Val Thr  Gln Ser Ile Lys Glu  Arg Lys Met 
    1715                 1720                 1725             


Leu Asn  Glu His Asp Phe Glu  Val Arg Gly Asp Val  Val Asn Gly 
    1730                 1735                 1740             


Arg Asn  His Gln Gly Pro Lys  Arg Ala Arg Glu Ser  Gln Asp Arg 
    1745                 1750                 1755             


Lys Ile  Phe Arg Gly Leu Glu  Ile Cys Cys Tyr Gly  Pro Phe Thr 
    1760                 1765                 1770             


Asn Met  Pro Thr Asp Gln Leu  Glu Trp Met Val Gln  Leu Cys Gly 
    1775                 1780                 1785             


Ala Ser  Val Val Lys Glu Leu  Ser Ser Phe Thr Leu  Gly Thr Gly 
    1790                 1795                 1800             


Val His  Pro Ile Val Val Val  Gln Pro Asp Ala Trp  Thr Glu Asp 
    1805                 1810                 1815             


Asn Gly  Phe His Ala Ile Gly  Gln Met Cys Glu Ala  Pro Val Val 
    1820                 1825                 1830             


Thr Arg  Glu Trp Val Leu Asp  Ser Val Ala Leu Tyr  Gln Cys Gln 
    1835                 1840                 1845             


Glu Leu  Asp Thr Tyr Leu Ile  Pro Gln Ile Pro His  Ser His Tyr 
    1850                 1855                 1860             


<210>  3680
<211>  1863
<212>  PRT
<213>  Homo sapiens

<400>  3680

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 
            180                 185                 190         


Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 
        195                 200                 205             


Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu 
            260                 265                 270         


Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn Ser 
        275                 280                 285             


Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe 
    290                 295                 300                 


Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg 
305                 310                 315                 320 


Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser Thr 
                325                 330                 335     


Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu 
            340                 345                 350         


Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr Glu 
        355                 360                 365             


Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn Glu 
    370                 375                 380                 


Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp 
385                 390                 395                 400 


Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu 
                405                 410                 415     


Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu 
            420                 425                 430         


Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His 
        435                 440                 445             


Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Thr 
    450                 455                 460                 


Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu Asn 
465                 470                 475                 480 


Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu Arg 
                485                 490                 495     


Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly Leu 
            500                 505                 510         


His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Thr 
        515                 520                 525             


Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly Gln 
    530                 535                 540                 


Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly Asp 
545                 550                 555                 560 


Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys 
                565                 570                 575     


Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser 
            580                 585                 590         


Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys 
        595                 600                 605             


Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu Glu 
    610                 615                 620                 


Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu Gln 
625                 630                 635                 640 


Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn 
                645                 650                 655     


Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys 
            660                 665                 670         


Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Thr 
        675                 680                 685             


Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr Asn 
    690                 695                 700                 


Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys Glu 
705                 710                 715                 720 


Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu 
                725                 730                 735     


Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu 
            740                 745                 750         


Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser Ser 
        755                 760                 765             


Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile Ser 
    770                 775                 780                 


Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn Lys 
785                 790                 795                 800 


Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His 
                805                 810                 815     


Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr Pro 
            820                 825                 830         


Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met Glu 
        835                 840                 845             


Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val Ser 
    850                 855                 860                 


Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu Glu 
865                 870                 875                 880 


Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser 
                885                 890                 895     


Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys 
            900                 905                 910         


Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala Gly 
        915                 920                 925             


Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys 
    930                 935                 940                 


Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly 
945                 950                 955                 960 


Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln Asn 
                965                 970                 975     


Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys Thr 
            980                 985                 990         


Lys Cys Lys Lys Asn Leu Leu Glu  Glu Asn Phe Glu Glu  His Ser Met 
        995                 1000                 1005             


Ser Pro  Glu Arg Glu Met Gly  Asn Glu Asn Ile Pro  Ser Thr Val 
    1010                 1015                 1020             


Ser Thr  Ile Ser Arg Asn Asn  Ile Arg Glu Asn Val  Phe Lys Glu 
    1025                 1030                 1035             


Ala Ser  Ser Ser Asn Ile Asn  Glu Val Gly Ser Ser  Thr Asn Glu 
    1040                 1045                 1050             


Val Gly  Ser Ser Ile Asn Glu  Ile Gly Ser Ser Asp  Glu Asn Ile 
    1055                 1060                 1065             


Gln Ala  Glu Leu Gly Arg Asn  Arg Gly Pro Lys Leu  Asn Ala Met 
    1070                 1075                 1080             


Leu Arg  Leu Gly Val Leu Gln  Pro Glu Val Tyr Lys  Gln Ser Leu 
    1085                 1090                 1095             


Pro Gly  Ser Asn Cys Lys His  Pro Glu Ile Lys Lys  Gln Glu Tyr 
    1100                 1105                 1110             


Glu Glu  Val Val Gln Thr Val  Asn Thr Asp Phe Ser  Pro Tyr Leu 
    1115                 1120                 1125             


Ile Ser  Asp Asn Leu Glu Gln  Pro Met Gly Ser Ser  His Ala Ser 
    1130                 1135                 1140             


Gln Val  Cys Ser Glu Thr Pro  Asp Asp Leu Leu Asp  Asp Gly Glu 
    1145                 1150                 1155             


Ile Lys  Glu Asp Thr Ser Phe  Ala Glu Asn Asp Ile  Lys Glu Ser 
    1160                 1165                 1170             


Ser Ala  Val Phe Ser Lys Ser  Val Gln Lys Gly Glu  Leu Ser Arg 
    1175                 1180                 1185             


Ser Pro  Ser Pro Phe Thr His  Thr His Leu Ala Gln  Gly Tyr Arg 
    1190                 1195                 1200             


Arg Gly  Ala Lys Lys Leu Glu  Ser Ser Glu Glu Asn  Leu Ser Ser 
    1205                 1210                 1215             


Glu Asp  Glu Glu Leu Pro Cys  Phe Gln His Leu Leu  Phe Gly Lys 
    1220                 1225                 1230             


Val Asn  Asn Ile Pro Ser Gln  Ser Thr Arg His Ser  Thr Val Ala 
    1235                 1240                 1245             


Thr Glu  Cys Leu Ser Lys Asn  Thr Glu Glu Asn Leu  Leu Ser Leu 
    1250                 1255                 1260             


Lys Asn  Ser Leu Asn Asp Cys  Ser Asn Gln Val Ile  Leu Ala Lys 
    1265                 1270                 1275             


Ala Ser  Gln Glu His His Leu  Ser Glu Glu Thr Lys  Cys Ser Ala 
    1280                 1285                 1290             


Ser Leu  Phe Ser Ser Gln Cys  Ser Glu Leu Glu Asp  Leu Thr Ala 
    1295                 1300                 1305             


Asn Thr  Asn Thr Gln Asp Pro  Phe Leu Ile Gly Ser  Ser Lys Gln 
    1310                 1315                 1320             


Met Arg  His Gln Ser Glu Ser  Gln Gly Val Gly Leu  Ser Asp Lys 
    1325                 1330                 1335             


Glu Leu  Val Ser Asp Asp Glu  Glu Arg Gly Thr Gly  Leu Glu Glu 
    1340                 1345                 1350             


Asn Asn  Gln Glu Glu Gln Ser  Met Asp Ser Asn Leu  Gly Glu Ala 
    1355                 1360                 1365             


Ala Ser  Gly Cys Glu Ser Glu  Thr Ser Val Ser Glu  Asp Cys Ser 
    1370                 1375                 1380             


Gly Leu  Ser Ser Gln Ser Asp  Ile Leu Thr Thr Gln  Gln Arg Asp 
    1385                 1390                 1395             


Thr Met  Gln His Asn Leu Ile  Lys Leu Gln Gln Glu  Met Ala Glu 
    1400                 1405                 1410             


Leu Glu  Ala Val Leu Glu Gln  His Gly Ser Gln Pro  Ser Asn Ser 
    1415                 1420                 1425             


Tyr Pro  Ser Ile Ile Ser Asp  Ser Ser Ala Leu Glu  Asp Leu Arg 
    1430                 1435                 1440             


Asn Pro  Glu Gln Ser Thr Ser  Glu Lys Ala Val Leu  Thr Ser Gln 
    1445                 1450                 1455             


Lys Ser  Ser Glu Tyr Pro Ile  Ser Gln Asn Pro Glu  Gly Leu Ser 
    1460                 1465                 1470             


Ala Asp  Lys Phe Glu Val Ser  Ala Asp Ser Ser Thr  Ser Lys Asn 
    1475                 1480                 1485             


Lys Glu  Pro Gly Val Glu Arg  Ser Ser Pro Ser Lys  Cys Pro Ser 
    1490                 1495                 1500             


Leu Asp  Asp Arg Trp Tyr Met  His Ser Cys Ser Gly  Ser Leu Gln 
    1505                 1510                 1515             


Asn Arg  Asn Tyr Pro Ser Gln  Glu Glu Leu Ile Lys  Val Val Asp 
    1520                 1525                 1530             


Val Glu  Glu Gln Gln Leu Glu  Glu Ser Gly Pro His  Asp Leu Thr 
    1535                 1540                 1545             


Glu Thr  Ser Tyr Leu Pro Arg  Gln Asp Leu Glu Gly  Thr Pro Tyr 
    1550                 1555                 1560             


Leu Glu  Ser Gly Ile Ser Leu  Phe Ser Asp Asp Pro  Glu Ser Asp 
    1565                 1570                 1575             


Pro Ser  Glu Asp Arg Ala Pro  Glu Ser Ala Arg Val  Gly Asn Ile 
    1580                 1585                 1590             


Pro Ser  Ser Thr Ser Ala Leu  Lys Val Pro Gln Leu  Lys Val Ala 
    1595                 1600                 1605             


Glu Ser  Ala Gln Ser Pro Ala  Ala Ala His Thr Thr  Asp Thr Ala 
    1610                 1615                 1620             


Gly Tyr  Asn Ala Met Glu Glu  Ser Val Ser Arg Glu  Lys Pro Glu 
    1625                 1630                 1635             


Leu Thr  Ala Ser Thr Glu Arg  Val Asn Lys Arg Met  Ser Met Val 
    1640                 1645                 1650             


Val Ser  Gly Leu Thr Pro Glu  Glu Phe Met Leu Val  Tyr Lys Phe 
    1655                 1660                 1665             


Ala Arg  Lys His His Ile Thr  Leu Thr Asn Leu Ile  Thr Glu Glu 
    1670                 1675                 1680             


Thr Thr  His Val Val Met Lys  Thr Asp Ala Glu Phe  Val Cys Glu 
    1685                 1690                 1695             


Arg Thr  Leu Lys Tyr Phe Leu  Gly Ile Ala Gly Gly  Lys Trp Val 
    1700                 1705                 1710             


Val Ser  Tyr Phe Trp Val Thr  Gln Ser Ile Lys Glu  Arg Lys Met 
    1715                 1720                 1725             


Leu Asn  Glu His Asp Phe Glu  Val Arg Gly Asp Val  Val Asn Gly 
    1730                 1735                 1740             


Arg Asn  His Gln Gly Pro Lys  Arg Ala Arg Glu Ser  Gln Asp Arg 
    1745                 1750                 1755             


Lys Ile  Phe Arg Gly Leu Glu  Ile Cys Cys Tyr Gly  Pro Phe Thr 
    1760                 1765                 1770             


Asn Met  Pro Thr Asp Gln Leu  Glu Trp Met Val Gln  Leu Cys Gly 
    1775                 1780                 1785             


Ala Ser  Val Val Lys Glu Leu  Ser Ser Phe Thr Leu  Gly Thr Gly 
    1790                 1795                 1800             


Val His  Pro Ile Val Val Val  Gln Pro Asp Ala Trp  Thr Glu Asp 
    1805                 1810                 1815             


Asn Gly  Phe His Ala Ile Gly  Gln Met Cys Glu Ala  Pro Val Val 
    1820                 1825                 1830             


Thr Arg  Glu Trp Val Leu Asp  Ser Val Ala Leu Tyr  Gln Cys Gln 
    1835                 1840                 1845             


Glu Leu  Asp Thr Tyr Leu Ile  Pro Gln Ile Pro His  Ser His Tyr 
    1850                 1855                 1860             


<210>  3681
<211>  1863
<212>  PRT
<213>  Homo sapiens

<400>  3681

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 
            180                 185                 190         


Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 
        195                 200                 205             


Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu 
            260                 265                 270         


Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn Ser 
        275                 280                 285             


Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe 
    290                 295                 300                 


Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg 
305                 310                 315                 320 


Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser Thr 
                325                 330                 335     


Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu 
            340                 345                 350         


Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr Glu 
        355                 360                 365             


Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn Glu 
    370                 375                 380                 


Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp 
385                 390                 395                 400 


Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu 
                405                 410                 415     


Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu 
            420                 425                 430         


Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His 
        435                 440                 445             


Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Thr 
    450                 455                 460                 


Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu Asn 
465                 470                 475                 480 


Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu Arg 
                485                 490                 495     


Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly Leu 
            500                 505                 510         


His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Thr 
        515                 520                 525             


Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly Gln 
    530                 535                 540                 


Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly Asp 
545                 550                 555                 560 


Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys 
                565                 570                 575     


Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser 
            580                 585                 590         


Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys 
        595                 600                 605             


Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu Glu 
    610                 615                 620                 


Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu Gln 
625                 630                 635                 640 


Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn 
                645                 650                 655     


Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys 
            660                 665                 670         


Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Thr 
        675                 680                 685             


Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr Asn 
    690                 695                 700                 


Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys Glu 
705                 710                 715                 720 


Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu 
                725                 730                 735     


Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu 
            740                 745                 750         


Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser Ser 
        755                 760                 765             


Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile Ser 
    770                 775                 780                 


Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn Lys 
785                 790                 795                 800 


Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His 
                805                 810                 815     


Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr Pro 
            820                 825                 830         


Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met Glu 
        835                 840                 845             


Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val Ser 
    850                 855                 860                 


Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu Glu 
865                 870                 875                 880 


Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser 
                885                 890                 895     


Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys 
            900                 905                 910         


Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala Gly 
        915                 920                 925             


Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys 
    930                 935                 940                 


Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly 
945                 950                 955                 960 


Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln Asn 
                965                 970                 975     


Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys Thr 
            980                 985                 990         


Lys Cys Lys Lys Asn Leu Leu Glu  Glu Asn Phe Glu Glu  His Ser Met 
        995                 1000                 1005             


Ser Pro  Glu Arg Glu Met Gly  Asn Glu Asn Ile Pro  Ser Thr Val 
    1010                 1015                 1020             


Ser Thr  Ile Ser Arg Asn Asn  Ile Arg Glu Asn Val  Phe Lys Glu 
    1025                 1030                 1035             


Ala Ser  Ser Ser Asn Ile Asn  Glu Val Gly Ser Ser  Thr Asn Glu 
    1040                 1045                 1050             


Val Gly  Ser Ser Ile Asn Glu  Ile Gly Ser Ser Asp  Glu Asn Ile 
    1055                 1060                 1065             


Gln Ala  Glu Leu Gly Arg Asn  Arg Gly Pro Lys Leu  Asn Ala Met 
    1070                 1075                 1080             


Leu Arg  Leu Gly Val Leu Gln  Pro Glu Val Tyr Lys  Gln Ser Leu 
    1085                 1090                 1095             


Pro Gly  Ser Asn Cys Lys His  Pro Glu Ile Lys Lys  Gln Glu Tyr 
    1100                 1105                 1110             


Glu Glu  Val Val Gln Thr Val  Asn Thr Asp Phe Ser  Pro Tyr Leu 
    1115                 1120                 1125             


Ile Ser  Asp Asn Leu Glu Gln  Pro Met Gly Ser Ser  His Ala Ser 
    1130                 1135                 1140             


Gln Val  Cys Ser Glu Thr Pro  Asp Asp Leu Leu Asp  Asp Gly Glu 
    1145                 1150                 1155             


Ile Lys  Glu Asp Thr Ser Phe  Ala Glu Asn Asp Ile  Lys Glu Ser 
    1160                 1165                 1170             


Ser Ala  Val Phe Ser Lys Ser  Val Gln Lys Gly Glu  Leu Ser Arg 
    1175                 1180                 1185             


Ser Pro  Ser Pro Phe Thr His  Thr His Leu Ala Gln  Gly Tyr Arg 
    1190                 1195                 1200             


Arg Gly  Ala Lys Lys Leu Glu  Ser Ser Glu Glu Asn  Leu Ser Ser 
    1205                 1210                 1215             


Glu Asp  Glu Glu Leu Pro Cys  Phe Gln His Leu Leu  Phe Gly Lys 
    1220                 1225                 1230             


Val Asn  Asn Ile Pro Ser Gln  Ser Thr Arg His Ser  Thr Val Ala 
    1235                 1240                 1245             


Thr Glu  Cys Leu Ser Lys Asn  Thr Glu Glu Asn Leu  Leu Ser Leu 
    1250                 1255                 1260             


Lys Asn  Ser Leu Asn Asp Cys  Ser Asn Gln Val Ile  Leu Ala Lys 
    1265                 1270                 1275             


Ala Ser  Gln Glu His His Leu  Ser Glu Glu Thr Lys  Cys Ser Ala 
    1280                 1285                 1290             


Ser Leu  Phe Ser Ser Gln Cys  Ser Glu Leu Glu Asp  Leu Thr Ala 
    1295                 1300                 1305             


Asn Thr  Asn Thr Gln Asp Pro  Phe Leu Ile Gly Ser  Ser Lys Gln 
    1310                 1315                 1320             


Met Arg  His Gln Ser Glu Ser  Gln Gly Val Gly Leu  Ser Asp Lys 
    1325                 1330                 1335             


Glu Leu  Val Ser Asp Asp Glu  Glu Arg Gly Thr Gly  Leu Glu Glu 
    1340                 1345                 1350             


Asn Asn  Gln Glu Glu Gln Ser  Met Asp Ser Asn Leu  Gly Glu Ala 
    1355                 1360                 1365             


Ala Ser  Gly Cys Glu Ser Glu  Thr Ser Val Ser Glu  Asp Cys Ser 
    1370                 1375                 1380             


Gly Leu  Ser Ser Gln Ser Asp  Ile Leu Thr Thr Gln  Gln Arg Asp 
    1385                 1390                 1395             


Thr Met  Gln His Asn Leu Ile  Lys Leu Gln Gln Glu  Met Ala Glu 
    1400                 1405                 1410             


Leu Glu  Ala Val Leu Glu Gln  His Gly Ser Gln Pro  Ser Asn Ser 
    1415                 1420                 1425             


Tyr Pro  Ser Ile Ile Ser Asp  Ser Ser Ala Leu Glu  Asp Leu Arg 
    1430                 1435                 1440             


Asn Pro  Glu Gln Ser Thr Ser  Glu Lys Ala Val Leu  Thr Ser Gln 
    1445                 1450                 1455             


Lys Ser  Ser Glu Tyr Pro Ile  Ser Gln Asn Pro Glu  Gly Leu Ser 
    1460                 1465                 1470             


Ala Asp  Lys Phe Glu Val Ser  Ala Asp Ser Ser Thr  Ser Lys Asn 
    1475                 1480                 1485             


Lys Glu  Pro Gly Val Glu Arg  Ser Ser Pro Ser Lys  Cys Pro Ser 
    1490                 1495                 1500             


Leu Asp  Asp Arg Trp Tyr Met  His Ser Cys Ser Gly  Ser Leu Gln 
    1505                 1510                 1515             


Asn Arg  Asn Tyr Pro Ser Gln  Glu Glu Leu Ile Lys  Val Val Asp 
    1520                 1525                 1530             


Val Glu  Glu Gln Gln Leu Glu  Glu Ser Gly Pro His  Asp Leu Thr 
    1535                 1540                 1545             


Glu Thr  Ser Tyr Leu Pro Arg  Gln Asp Leu Glu Gly  Thr Pro Tyr 
    1550                 1555                 1560             


Leu Glu  Ser Gly Ile Ser Leu  Phe Ser Asp Asp Pro  Glu Ser Asp 
    1565                 1570                 1575             


Pro Ser  Glu Asp Arg Ala Pro  Glu Ser Ala Arg Val  Gly Asn Ile 
    1580                 1585                 1590             


Pro Ser  Ser Thr Ser Ala Leu  Lys Val Pro Gln Leu  Lys Val Ala 
    1595                 1600                 1605             


Glu Ser  Ala Gln Ser Pro Ala  Ala Ala His Thr Thr  Asp Thr Ala 
    1610                 1615                 1620             


Gly Tyr  Asn Ala Met Glu Glu  Ser Val Ser Arg Glu  Lys Pro Glu 
    1625                 1630                 1635             


Leu Thr  Ala Ser Thr Glu Arg  Val Asn Lys Arg Met  Ser Met Val 
    1640                 1645                 1650             


Val Ser  Gly Leu Thr Pro Glu  Glu Phe Met Leu Val  Tyr Lys Phe 
    1655                 1660                 1665             


Ala Arg  Lys His His Ile Thr  Leu Thr Asn Leu Ile  Thr Glu Glu 
    1670                 1675                 1680             


Thr Thr  His Val Val Met Lys  Thr Asp Ala Glu Phe  Val Cys Glu 
    1685                 1690                 1695             


Arg Thr  Leu Lys Tyr Phe Leu  Gly Ile Ala Gly Gly  Lys Trp Val 
    1700                 1705                 1710             


Val Ser  Tyr Phe Trp Val Thr  Gln Ser Ile Lys Glu  Arg Lys Met 
    1715                 1720                 1725             


Leu Asn  Glu His Asp Phe Glu  Val Arg Gly Asp Val  Val Asn Gly 
    1730                 1735                 1740             


Arg Asn  His Gln Gly Pro Lys  Arg Ala Arg Glu Ser  Gln Asp Arg 
    1745                 1750                 1755             


Lys Ile  Phe Arg Gly Leu Glu  Ile Cys Cys Tyr Gly  Pro Phe Thr 
    1760                 1765                 1770             


Asn Met  Pro Thr Asp Gln Leu  Glu Trp Met Val Gln  Leu Cys Gly 
    1775                 1780                 1785             


Ala Ser  Val Val Lys Glu Leu  Ser Ser Phe Thr Leu  Gly Thr Gly 
    1790                 1795                 1800             


Val His  Pro Ile Val Val Val  Gln Pro Asp Ala Trp  Thr Glu Asp 
    1805                 1810                 1815             


Asn Gly  Phe His Ala Ile Gly  Gln Met Cys Glu Ala  Pro Val Val 
    1820                 1825                 1830             


Thr Arg  Glu Trp Val Leu Asp  Ser Val Ala Leu Tyr  Gln Cys Gln 
    1835                 1840                 1845             


Glu Leu  Asp Thr Tyr Leu Ile  Pro Gln Ile Pro His  Ser His Tyr 
    1850                 1855                 1860             


<210>  3682
<211>  1863
<212>  PRT
<213>  Homo sapiens

<400>  3682

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 
            180                 185                 190         


Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 
        195                 200                 205             


Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu 
            260                 265                 270         


Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn Ser 
        275                 280                 285             


Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe 
    290                 295                 300                 


Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg 
305                 310                 315                 320 


Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser Thr 
                325                 330                 335     


Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu 
            340                 345                 350         


Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr Glu 
        355                 360                 365             


Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn Glu 
    370                 375                 380                 


Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp 
385                 390                 395                 400 


Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu 
                405                 410                 415     


Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu 
            420                 425                 430         


Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His 
        435                 440                 445             


Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Thr 
    450                 455                 460                 


Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu Asn 
465                 470                 475                 480 


Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu Arg 
                485                 490                 495     


Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly Leu 
            500                 505                 510         


His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Thr 
        515                 520                 525             


Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly Gln 
    530                 535                 540                 


Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly Asp 
545                 550                 555                 560 


Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys 
                565                 570                 575     


Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser 
            580                 585                 590         


Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys 
        595                 600                 605             


Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu Glu 
    610                 615                 620                 


Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu Gln 
625                 630                 635                 640 


Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn 
                645                 650                 655     


Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys 
            660                 665                 670         


Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Thr 
        675                 680                 685             


Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr Asn 
    690                 695                 700                 


Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys Glu 
705                 710                 715                 720 


Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu 
                725                 730                 735     


Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu 
            740                 745                 750         


Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser Ser 
        755                 760                 765             


Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile Ser 
    770                 775                 780                 


Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn Lys 
785                 790                 795                 800 


Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His 
                805                 810                 815     


Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr Pro 
            820                 825                 830         


Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met Glu 
        835                 840                 845             


Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val Ser 
    850                 855                 860                 


Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu Glu 
865                 870                 875                 880 


Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser 
                885                 890                 895     


Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys 
            900                 905                 910         


Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala Gly 
        915                 920                 925             


Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys 
    930                 935                 940                 


Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly 
945                 950                 955                 960 


Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln Asn 
                965                 970                 975     


Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys Thr 
            980                 985                 990         


Lys Cys Lys Lys Asn Leu Leu Glu  Glu Asn Phe Glu Glu  His Ser Met 
        995                 1000                 1005             


Ser Pro  Glu Arg Glu Met Gly  Asn Glu Asn Ile Pro  Ser Thr Val 
    1010                 1015                 1020             


Ser Thr  Ile Ser Arg Asn Asn  Ile Arg Glu Asn Val  Phe Lys Glu 
    1025                 1030                 1035             


Ala Ser  Ser Ser Asn Ile Asn  Glu Val Gly Ser Ser  Thr Asn Glu 
    1040                 1045                 1050             


Val Gly  Ser Ser Ile Asn Glu  Ile Gly Ser Ser Asp  Glu Asn Ile 
    1055                 1060                 1065             


Gln Ala  Glu Leu Gly Arg Asn  Arg Gly Pro Lys Leu  Asn Ala Met 
    1070                 1075                 1080             


Leu Arg  Leu Gly Val Leu Gln  Pro Glu Val Tyr Lys  Gln Ser Leu 
    1085                 1090                 1095             


Pro Gly  Ser Asn Cys Lys His  Pro Glu Ile Lys Lys  Gln Glu Tyr 
    1100                 1105                 1110             


Glu Glu  Val Val Gln Thr Val  Asn Thr Asp Phe Ser  Pro Tyr Leu 
    1115                 1120                 1125             


Ile Ser  Asp Asn Leu Glu Gln  Pro Met Gly Ser Ser  His Ala Ser 
    1130                 1135                 1140             


Gln Val  Cys Ser Glu Thr Pro  Asp Asp Leu Leu Asp  Asp Gly Glu 
    1145                 1150                 1155             


Ile Lys  Glu Asp Thr Ser Phe  Ala Glu Asn Asp Ile  Lys Glu Ser 
    1160                 1165                 1170             


Ser Ala  Val Phe Ser Lys Ser  Val Gln Lys Gly Glu  Leu Ser Arg 
    1175                 1180                 1185             


Ser Pro  Ser Pro Phe Thr His  Thr His Leu Ala Gln  Gly Tyr Arg 
    1190                 1195                 1200             


Arg Gly  Ala Lys Lys Leu Glu  Ser Ser Glu Glu Asn  Leu Ser Ser 
    1205                 1210                 1215             


Glu Asp  Glu Glu Leu Pro Cys  Phe Gln His Leu Leu  Phe Gly Lys 
    1220                 1225                 1230             


Val Asn  Asn Ile Pro Ser Gln  Ser Thr Arg His Ser  Thr Val Ala 
    1235                 1240                 1245             


Thr Glu  Cys Leu Ser Lys Asn  Thr Glu Glu Asn Leu  Leu Ser Leu 
    1250                 1255                 1260             


Lys Asn  Ser Leu Asn Asp Cys  Ser Asn Gln Val Ile  Leu Ala Lys 
    1265                 1270                 1275             


Ala Ser  Gln Glu His His Leu  Ser Glu Glu Thr Lys  Cys Ser Ala 
    1280                 1285                 1290             


Ser Leu  Phe Ser Ser Gln Cys  Ser Glu Leu Glu Asp  Leu Thr Ala 
    1295                 1300                 1305             


Asn Thr  Asn Thr Gln Asp Pro  Phe Leu Ile Gly Ser  Ser Lys Gln 
    1310                 1315                 1320             


Met Arg  His Gln Ser Glu Ser  Gln Gly Val Gly Leu  Ser Asp Lys 
    1325                 1330                 1335             


Glu Leu  Val Ser Asp Asp Glu  Glu Arg Gly Thr Gly  Leu Glu Glu 
    1340                 1345                 1350             


Asn Asn  Gln Glu Glu Gln Ser  Met Asp Ser Asn Leu  Gly Glu Ala 
    1355                 1360                 1365             


Ala Ser  Gly Cys Glu Ser Glu  Thr Ser Val Ser Glu  Asp Cys Ser 
    1370                 1375                 1380             


Gly Leu  Ser Ser Gln Ser Asp  Ile Leu Thr Thr Gln  Gln Arg Asp 
    1385                 1390                 1395             


Thr Met  Gln His Asn Leu Ile  Lys Leu Gln Gln Glu  Met Ala Glu 
    1400                 1405                 1410             


Leu Glu  Ala Val Leu Glu Gln  His Gly Ser Gln Pro  Ser Asn Ser 
    1415                 1420                 1425             


Tyr Pro  Ser Ile Ile Ser Asp  Ser Ser Ala Leu Glu  Asp Leu Arg 
    1430                 1435                 1440             


Asn Pro  Glu Gln Ser Thr Ser  Glu Lys Ala Val Leu  Thr Ser Gln 
    1445                 1450                 1455             


Lys Ser  Ser Glu Tyr Pro Ile  Ser Gln Asn Pro Glu  Gly Leu Ser 
    1460                 1465                 1470             


Ala Asp  Lys Phe Glu Val Ser  Ala Asp Ser Ser Thr  Ser Lys Asn 
    1475                 1480                 1485             


Lys Glu  Pro Gly Val Glu Arg  Ser Ser Pro Ser Lys  Cys Pro Ser 
    1490                 1495                 1500             


Leu Asp  Asp Arg Trp Tyr Met  His Ser Cys Ser Gly  Ser Leu Gln 
    1505                 1510                 1515             


Asn Arg  Asn Tyr Pro Ser Gln  Glu Glu Leu Ile Lys  Val Val Asp 
    1520                 1525                 1530             


Val Glu  Glu Gln Gln Leu Glu  Glu Ser Gly Pro His  Asp Leu Thr 
    1535                 1540                 1545             


Glu Thr  Ser Tyr Leu Pro Arg  Gln Asp Leu Glu Gly  Thr Pro Tyr 
    1550                 1555                 1560             


Leu Glu  Ser Gly Ile Ser Leu  Phe Ser Asp Asp Pro  Glu Ser Asp 
    1565                 1570                 1575             


Pro Ser  Glu Asp Arg Ala Pro  Glu Ser Ala Arg Val  Gly Asn Ile 
    1580                 1585                 1590             


Pro Ser  Ser Thr Ser Ala Leu  Lys Val Pro Gln Leu  Lys Val Ala 
    1595                 1600                 1605             


Glu Ser  Ala Gln Ser Pro Ala  Ala Ala His Thr Thr  Asp Thr Ala 
    1610                 1615                 1620             


Gly Tyr  Asn Ala Met Glu Glu  Ser Val Ser Arg Glu  Lys Pro Glu 
    1625                 1630                 1635             


Leu Thr  Ala Ser Thr Glu Arg  Val Asn Lys Arg Met  Ser Met Val 
    1640                 1645                 1650             


Val Ser  Gly Leu Thr Pro Glu  Glu Phe Met Leu Val  Tyr Lys Phe 
    1655                 1660                 1665             


Ala Arg  Lys His His Ile Thr  Leu Thr Asn Leu Ile  Thr Glu Glu 
    1670                 1675                 1680             


Thr Thr  His Val Val Met Lys  Thr Asp Ala Glu Phe  Val Cys Glu 
    1685                 1690                 1695             


Arg Thr  Leu Lys Tyr Phe Leu  Gly Ile Ala Gly Gly  Lys Trp Val 
    1700                 1705                 1710             


Val Ser  Tyr Phe Trp Val Thr  Gln Ser Ile Lys Glu  Arg Lys Met 
    1715                 1720                 1725             


Leu Asn  Glu His Asp Phe Glu  Val Arg Gly Asp Val  Val Asn Gly 
    1730                 1735                 1740             


Arg Asn  His Gln Gly Pro Lys  Arg Ala Arg Glu Ser  Gln Asp Arg 
    1745                 1750                 1755             


Lys Ile  Phe Arg Gly Leu Glu  Ile Cys Cys Tyr Gly  Pro Phe Thr 
    1760                 1765                 1770             


Asn Met  Pro Thr Asp Gln Leu  Glu Trp Met Val Gln  Leu Cys Gly 
    1775                 1780                 1785             


Ala Ser  Val Val Lys Glu Leu  Ser Ser Phe Thr Leu  Gly Thr Gly 
    1790                 1795                 1800             


Val His  Pro Ile Val Val Val  Gln Pro Asp Ala Trp  Thr Glu Asp 
    1805                 1810                 1815             


Asn Gly  Phe His Ala Ile Gly  Gln Met Cys Glu Ala  Pro Val Val 
    1820                 1825                 1830             


Thr Arg  Glu Trp Val Leu Asp  Ser Val Ala Leu Tyr  Gln Cys Gln 
    1835                 1840                 1845             


Glu Leu  Asp Thr Tyr Leu Ile  Pro Gln Ile Pro His  Ser His Tyr 
    1850                 1855                 1860             


<210>  3683
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  3683

Met Gly Asp Thr Lys Glu Gln Arg Ile Leu Asn His Val Leu Gln His 
1               5                   10                  15      


Ala Glu Pro Gly Asn Ala Gln Ser Val Leu Glu Ala Ile Asp Thr Tyr 
            20                  25                  30          


Cys Glu Gln Lys Glu Trp Ala Met Asn Val Gly Asp Lys Lys Gly Lys 
        35                  40                  45              


Ile Val Asp Ala Val Ile Gln Glu His Gln Pro Ser Val Leu Leu Glu 
    50                  55                  60                  


Leu Gly Ala Tyr Cys Gly Tyr Ser Ala Val Arg Met Ala Arg Leu Leu 
65                  70                  75                  80  


Ser Pro Gly Ala Arg Leu Ile Thr Ile Glu Ile Asn Pro Asp Cys Ala 
                85                  90                  95      


Ala Ile Thr Gln Arg Met Val Asp Phe Ala Gly Val Lys Asp Lys Val 
            100                 105                 110         


Thr Leu Val Val Gly Ala Ser Gln Asp Ile Ile Pro Gln Leu Lys Lys 
        115                 120                 125             


Lys Tyr Asp Val Asp Thr Leu Asp Met Val Phe Leu Asp His Trp Lys 
    130                 135                 140                 


Asp Arg Tyr Leu Pro Asp Thr Leu Leu Leu Glu Glu Cys Gly Leu Leu 
145                 150                 155                 160 


Arg Lys Gly Thr Val Leu Leu Ala Asp Asn Val Ile Cys Pro Gly Ala 
                165                 170                 175     


Pro Asp Phe Leu Ala His Val Arg Gly Ser Ser Cys Phe Glu Cys Thr 
            180                 185                 190         


His Tyr Gln Ser Phe Leu Glu Tyr Arg Glu Val Val Asp Gly Leu Glu 
        195                 200                 205             


Lys Ala Ile Tyr Lys Gly Pro Gly Ser Glu Ala Gly Pro 
    210                 215                 220     


<210>  3684
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  3684

Met Ala Pro Pro Trp Val Pro Ala Met Gly Phe Thr Leu Ala Pro Ser 
1               5                   10                  15      


Leu Gly Cys Phe Val Gly Ser Arg Phe Val His Gly Glu Gly Leu Arg 
            20                  25                  30          


Trp Tyr Ala Gly Leu Gln Lys Pro Ser Trp His Pro Pro His Trp Val 
        35                  40                  45              


Leu Gly Pro Val Trp Gly Thr Leu Tyr Ser Ala Met Gly Tyr Gly Ser 
    50                  55                  60                  


Tyr Leu Val Trp Lys Glu Leu Gly Gly Phe Thr Glu Lys Ala Val Val 
65                  70                  75                  80  


Pro Leu Gly Leu Tyr Thr Gly Gln Leu Ala Leu Asn Trp Ala Trp Pro 
                85                  90                  95      


Pro Ile Phe Phe Gly Ala Arg Gln Met Gly Trp Ala Leu Val Asp Leu 
            100                 105                 110         


Leu Leu Val Ser Gly Ala Ala Ala Ala Thr Thr Val Ala Trp Tyr Gln 
        115                 120                 125             


Val Ser Pro Leu Ala Ala Arg Leu Leu Tyr Pro Tyr Leu Ala Trp Leu 
    130                 135                 140                 


Ala Phe Thr Thr Thr Leu Asn Tyr Cys Val Trp Arg Asp Asn His Gly 
145                 150                 155                 160 


Trp Arg Gly Gly Arg Arg Leu Pro Glu 
                165                 


<210>  3685
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  3685

Met Thr Glu Leu Pro Ala Pro Leu Ser Tyr Phe Gln Asn Ala Gln Met 
1               5                   10                  15      


Ser Glu Asp Asn His Leu Ser Asn Thr Asn Asp Asn Arg Glu Arg Gln 
            20                  25                  30          


Glu His Asn Asp Arg Arg Ser Leu Gly His Pro Glu Pro Leu Ser Asn 
        35                  40                  45              


Gly Arg Pro Gln Gly Asn Ser Arg Gln Val Val Glu Gln Asp Glu Glu 
    50                  55                  60                  


Glu Asp Glu Glu Leu Thr Leu Lys Tyr Gly Ala Lys His Val Ile Met 
65                  70                  75                  80  


Leu Phe Val Pro Val Thr Leu Cys Met Val Val Val Val Ala Thr Ile 
                85                  90                  95      


Lys Ser Val Ser Phe Tyr Thr Arg Lys Asp Gly Gln Leu Ile Tyr Thr 
            100                 105                 110         


Pro Phe Thr Glu Asp Thr Glu Thr Val Gly Gln Arg Ala Leu His Ser 
        115                 120                 125             


Ile Leu Asn Ala Ala Ile Met Ile Ser Val Ile Val Val Met Thr Ile 
    130                 135                 140                 


Leu Leu Val Val Leu Tyr Lys Tyr Arg Cys Tyr Lys Val Ile His Ala 
145                 150                 155                 160 


Trp Leu Ile Ile Ser Ser Leu Leu Leu Leu Phe Phe Phe Ser Phe Ile 
                165                 170                 175     


Tyr Leu Gly Glu Val Phe Lys Thr Tyr Asn Val Ala Val Asp Tyr Ile 
            180                 185                 190         


Thr Val Ala Leu Leu Ile Trp Asn Phe Gly Val Val Gly Met Ile Ser 
        195                 200                 205             


Ile His Trp Lys Gly Pro Leu Arg Leu Gln Gln Ala Tyr Leu Ile Met 
    210                 215                 220                 


Ile Ser Ala Leu Met Ala Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp 
225                 230                 235                 240 


Thr Ala Trp Leu Ile Leu Ala Val Ile Ser Val Tyr Asp Leu Val Ala 
                245                 250                 255     


Val Leu Cys Pro Lys Gly Pro Leu Arg Met Leu Val Glu Thr Ala Gln 
            260                 265                 270         


Glu Arg Asn Glu Thr Leu Phe Pro Ala Leu Ile Tyr Ser Ser Thr Met 
        275                 280                 285             


Val Trp Leu Val Asn Met Ala Glu Gly Asp Pro Glu Ala Gln Arg Arg 
    290                 295                 300                 


Val Ser Lys Asn Ser Lys Tyr Asn Ala Glu Ser Thr Glu Arg Glu Ser 
305                 310                 315                 320 


Gln Asp Thr Val Ala Glu Asn Asp Asp Gly Gly Phe Ser Glu Glu Trp 
                325                 330                 335     


Glu Ala Gln Arg Asp Ser His Leu Gly Pro His Arg Ser Thr Pro Glu 
            340                 345                 350         


Ser Arg Ala Ala Val Gln Glu Leu Ser Ser Ser Ile Leu Ala Gly Glu 
        355                 360                 365             


Asp Pro Glu Glu Arg Gly Val Lys Leu Gly Leu Gly Asp Phe Ile Phe 
    370                 375                 380                 


Tyr Ser Val Leu Val Gly Lys Ala Ser Ala Thr Ala Ser Gly Asp Trp 
385                 390                 395                 400 


Asn Thr Thr Ile Ala Cys Phe Val Ala Ile Leu Ile Gly Leu Cys Leu 
                405                 410                 415     


Thr Leu Leu Leu Leu Ala Ile Phe Lys Lys Ala Leu Pro Ala Leu Pro 
            420                 425                 430         


Ile Ser Ile Thr Phe Gly Leu Val Phe Tyr Phe Ala Thr Asp Tyr Leu 
        435                 440                 445             


Val Gln Pro Phe Met Asp Gln Leu Ala Phe His Gln Phe Tyr Ile 
    450                 455                 460             


<210>  3686
<211>  894
<212>  PRT
<213>  Homo sapiens

<400>  3686

Met Ala Arg Gln Lys Lys Met Gly Gln Ser Val Leu Arg Ala Val Phe 
1               5                   10                  15      


Phe Leu Val Leu Gly Leu Leu Gly His Ser His Gly Gly Phe Pro Asn 
            20                  25                  30          


Thr Ile Ser Ile Gly Gly Leu Phe Met Arg Asn Thr Val Gln Glu His 
        35                  40                  45              


Ser Ala Phe Arg Phe Ala Val Gln Leu Tyr Asn Thr Asn Gln Asn Thr 
    50                  55                  60                  


Thr Glu Lys Pro Phe His Leu Asn Tyr His Val Asp His Leu Asp Ser 
65                  70                  75                  80  


Ser Asn Ser Phe Ser Val Thr Asn Ala Phe Cys Ser Gln Phe Ser Arg 
                85                  90                  95      


Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Gln Met Ser Met Asn Thr 
            100                 105                 110         


Leu Thr Ser Phe Cys Gly Ala Leu His Thr Ser Phe Val Thr Pro Ser 
        115                 120                 125             


Phe Pro Thr Asp Ala Asp Val Gln Phe Val Ile Gln Met Arg Pro Ala 
    130                 135                 140                 


Leu Lys Gly Ala Ile Leu Ser Leu Leu Gly His Tyr Lys Trp Glu Lys 
145                 150                 155                 160 


Phe Val Tyr Leu Tyr Asp Thr Glu Arg Gly Phe Ser Ile Leu Gln Ala 
                165                 170                 175     


Ile Met Glu Ala Ala Val Gln Asn Asn Trp Gln Val Thr Ala Arg Ser 
            180                 185                 190         


Val Gly Asn Ile Lys Asp Val Gln Glu Phe Arg Arg Ile Ile Glu Glu 
        195                 200                 205             


Met Asp Arg Arg Gln Glu Lys Arg Tyr Leu Ile Asp Cys Glu Val Glu 
    210                 215                 220                 


Arg Ile Asn Thr Ile Leu Glu Gln Val Val Ile Leu Gly Lys His Ser 
225                 230                 235                 240 


Arg Gly Tyr His Tyr Met Leu Ala Asn Leu Gly Phe Thr Asp Ile Leu 
                245                 250                 255     


Leu Glu Arg Val Met His Gly Gly Ala Asn Ile Thr Gly Phe Gln Ile 
            260                 265                 270         


Val Asn Asn Glu Asn Pro Met Val Gln Gln Phe Ile Gln Arg Trp Val 
        275                 280                 285             


Arg Leu Asp Glu Arg Glu Phe Pro Glu Ala Lys Asn Ala Pro Leu Lys 
    290                 295                 300                 


Tyr Thr Ser Ala Leu Thr His Asp Ala Ile Leu Val Ile Ala Glu Ala 
305                 310                 315                 320 


Phe Arg Tyr Leu Arg Arg Gln Arg Val Asp Val Ser Arg Arg Gly Ser 
                325                 330                 335     


Ala Gly Asp Cys Leu Ala Asn Pro Ala Val Pro Trp Ser Gln Gly Ile 
            340                 345                 350         


Asp Ile Glu Arg Ala Leu Lys Met Val Gln Val Gln Gly Met Thr Gly 
        355                 360                 365             


Asn Ile Gln Phe Asp Thr Tyr Gly Arg Arg Thr Asn Tyr Thr Ile Asp 
    370                 375                 380                 


Val Tyr Glu Met Lys Val Ser Gly Ser Arg Lys Ala Gly Tyr Trp Asn 
385                 390                 395                 400 


Glu Tyr Glu Arg Phe Val Pro Phe Ser Asp Gln Gln Ile Ser Asn Asp 
                405                 410                 415     


Ser Ala Ser Ser Glu Asn Arg Thr Ile Val Val Thr Thr Ile Leu Glu 
            420                 425                 430         


Ser Pro Tyr Val Met Tyr Lys Lys Asn His Glu Gln Leu Glu Gly Asn 
        435                 440                 445             


Glu Arg Tyr Glu Gly Tyr Cys Val Asp Leu Ala Tyr Glu Ile Ala Lys 
    450                 455                 460                 


His Val Arg Ile Lys Tyr Lys Leu Ser Ile Val Gly Asp Gly Lys Tyr 
465                 470                 475                 480 


Gly Ala Arg Asp Pro Glu Thr Lys Ile Trp Asn Gly Met Val Gly Glu 
                485                 490                 495     


Leu Val Tyr Gly Arg Ala Asp Ile Ala Val Ala Pro Leu Thr Ile Thr 
            500                 505                 510         


Leu Val Arg Glu Glu Val Ile Asp Phe Ser Lys Pro Phe Met Ser Leu 
        515                 520                 525             


Gly Ile Ser Ile Met Ile Lys Lys Pro Gln Lys Ser Lys Pro Gly Val 
    530                 535                 540                 


Phe Ser Phe Leu Asp Pro Leu Ala Tyr Glu Ile Trp Met Cys Ile Val 
545                 550                 555                 560 


Phe Ala Tyr Ile Gly Val Ser Val Val Leu Phe Leu Val Ser Arg Phe 
                565                 570                 575     


Ser Pro Tyr Glu Trp His Leu Glu Asp Asn Asn Glu Glu Pro Arg Asp 
            580                 585                 590         


Pro Gln Ser Pro Pro Asp Pro Pro Asn Glu Phe Gly Ile Phe Asn Ser 
        595                 600                 605             


Leu Trp Phe Ser Leu Gly Ala Phe Met Gln Gln Gly Cys Asp Ile Ser 
    610                 615                 620                 


Pro Arg Ser Leu Ser Gly Arg Ile Val Gly Gly Val Trp Trp Phe Phe 
625                 630                 635                 640 


Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu 
                645                 650                 655     


Thr Val Glu Arg Met Val Ser Pro Ile Glu Ser Ala Glu Asp Leu Ala 
            660                 665                 670         


Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu Asp Ser Gly Ser Thr Lys 
        675                 680                 685             


Glu Phe Phe Arg Arg Ser Lys Ile Ala Val Tyr Glu Lys Met Trp Ser 
    690                 695                 700                 


Tyr Met Lys Ser Ala Glu Pro Ser Val Phe Thr Lys Thr Thr Ala Asp 
705                 710                 715                 720 


Gly Val Ala Arg Val Arg Lys Ser Lys Gly Lys Phe Ala Phe Leu Leu 
                725                 730                 735     


Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln Arg Lys Pro Cys Asp Thr 
            740                 745                 750         


Met Lys Val Gly Gly Asn Leu Asp Ser Lys Gly Tyr Gly Val Ala Thr 
        755                 760                 765             


Pro Lys Gly Ser Ala Leu Gly Thr Pro Val Asn Leu Ala Val Leu Lys 
    770                 775                 780                 


Leu Ser Glu Gln Gly Ile Leu Asp Lys Leu Lys Asn Lys Trp Trp Tyr 
785                 790                 795                 800 


Asp Lys Gly Glu Cys Gly Ala Lys Asp Ser Gly Ser Lys Asp Lys Thr 
                805                 810                 815     


Ser Ala Leu Ser Leu Ser Asn Val Ala Gly Val Phe Tyr Ile Leu Val 
            820                 825                 830         


Gly Gly Leu Gly Leu Ala Met Met Val Ala Leu Ile Glu Phe Cys Tyr 
        835                 840                 845             


Lys Ser Arg Ala Glu Ser Lys Arg Met Lys Leu Thr Lys Asn Thr Gln 
    850                 855                 860                 


Asn Phe Lys Pro Ala Pro Ala Thr Asn Thr Gln Asn Tyr Ala Thr Tyr 
865                 870                 875                 880 


Arg Glu Gly Tyr Asn Val Tyr Gly Thr Glu Ser Val Lys Ile 
                885                 890                 


<210>  3687
<211>  938
<212>  PRT
<213>  Homo sapiens

<400>  3687

Met Ser Thr Met Arg Leu Leu Thr Leu Ala Leu Leu Phe Ser Cys Ser 
1               5                   10                  15      


Val Ala Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile Gly Ala Val 
            20                  25                  30          


Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala Val Asn Gln 
        35                  40                  45              


Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn Ala Thr Ser 
    50                  55                  60                  


Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser Val Cys Glu 
65                  70                  75                  80  


Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser His Pro Pro 
                85                  90                  95      


Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr Thr Ala Gly 
            100                 105                 110         


Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met Ser Ile Tyr 
        115                 120                 125             


Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val Pro Pro Tyr 
    130                 135                 140                 


Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val Tyr Ser Trp 
145                 150                 155                 160 


Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly Arg Ala Ala 
                165                 170                 175     


Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser Lys Ala Glu 
            180                 185                 190         


Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn Val Thr Ala Leu Leu 
        195                 200                 205             


Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile Ile Leu Ser Ala Ser 
    210                 215                 220                 


Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala Ala Met Leu Asn Met 
225                 230                 235                 240 


Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu Arg Glu Ile Ser Gly 
                245                 250                 255     


Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu Gly Leu Gln Leu Ile 
            260                 265                 270         


Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp Ala Val Gly Val Val 
        275                 280                 285             


Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu Asn Ile Thr Asp Pro 
    290                 295                 300                 


Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp Lys Thr Gly Pro Leu 
305                 310                 315                 320 


Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala Asp Gly Val Thr Gly 
                325                 330                 335     


Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys Phe Ala Asn Tyr Ser 
            340                 345                 350         


Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln Val Gly Ile Tyr Asn 
        355                 360                 365             


Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile Ile Trp Pro Gly Gly 
    370                 375                 380                 


Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met Ser Thr Arg Leu Lys Ile 
385                 390                 395                 400 


Val Thr Ile His Gln Glu Pro Phe Val Tyr Val Lys Pro Thr Leu Ser 
                405                 410                 415     


Asp Gly Thr Cys Lys Glu Glu Phe Thr Val Asn Gly Asp Pro Val Lys 
            420                 425                 430         


Lys Val Ile Cys Thr Gly Pro Asn Asp Thr Ser Pro Gly Ser Pro Arg 
        435                 440                 445             


His Thr Val Pro Gln Cys Cys Tyr Gly Phe Cys Ile Asp Leu Leu Ile 
    450                 455                 460                 


Lys Leu Ala Arg Thr Met Asn Phe Thr Tyr Glu Val His Leu Val Ala 
465                 470                 475                 480 


Asp Gly Lys Phe Gly Thr Gln Glu Arg Val Asn Asn Ser Asn Lys Lys 
                485                 490                 495     


Glu Trp Asn Gly Met Met Gly Glu Leu Leu Ser Gly Gln Ala Asp Met 
            500                 505                 510         


Ile Val Ala Pro Leu Thr Ile Asn Asn Glu Arg Ala Gln Tyr Ile Glu 
        515                 520                 525             


Phe Ser Lys Pro Phe Lys Tyr Gln Gly Leu Thr Ile Leu Val Lys Lys 
    530                 535                 540                 


Glu Ile Pro Arg Ser Thr Leu Asp Ser Phe Met Gln Pro Phe Gln Ser 
545                 550                 555                 560 


Thr Leu Trp Leu Leu Val Gly Leu Ser Val His Val Val Ala Val Met 
                565                 570                 575     


Leu Tyr Leu Leu Asp Arg Phe Ser Pro Phe Gly Arg Phe Lys Val Asn 
            580                 585                 590         


Ser Glu Glu Glu Glu Glu Asp Ala Leu Thr Leu Ser Ser Ala Met Trp 
        595                 600                 605             


Phe Ser Trp Gly Val Leu Leu Asn Ser Gly Ile Gly Glu Gly Ala Pro 
    610                 615                 620                 


Arg Ser Phe Ser Ala Arg Ile Leu Gly Met Val Trp Ala Gly Phe Ala 
625                 630                 635                 640 


Met Ile Ile Val Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu Val 
                645                 650                 655     


Leu Asp Arg Pro Glu Glu Arg Ile Thr Gly Ile Asn Asp Pro Arg Leu 
            660                 665                 670         


Arg Asn Pro Ser Asp Lys Phe Ile Tyr Ala Thr Val Lys Gln Ser Ser 
        675                 680                 685             


Val Asp Ile Tyr Phe Arg Arg Gln Val Glu Leu Ser Thr Met Tyr Arg 
    690                 695                 700                 


His Met Glu Lys His Asn Tyr Glu Ser Ala Ala Glu Ala Ile Gln Ala 
705                 710                 715                 720 


Val Arg Asp Asn Lys Leu His Ala Phe Ile Trp Asp Ser Ala Val Leu 
                725                 730                 735     


Glu Phe Glu Ala Ser Gln Lys Cys Asp Leu Val Thr Thr Gly Glu Leu 
            740                 745                 750         


Phe Phe Arg Ser Gly Phe Gly Ile Gly Met Arg Lys Asp Ser Pro Trp 
        755                 760                 765             


Lys Gln Asn Val Ser Leu Ser Ile Leu Lys Ser His Glu Asn Gly Phe 
    770                 775                 780                 


Met Glu Asp Leu Asp Lys Thr Trp Val Arg Tyr Gln Glu Cys Asp Ser 
785                 790                 795                 800 


Arg Ser Asn Ala Pro Ala Thr Leu Thr Phe Glu Asn Met Ala Gly Val 
                805                 810                 815     


Phe Met Leu Val Ala Gly Gly Ile Val Ala Gly Ile Phe Leu Ile Phe 
            820                 825                 830         


Ile Glu Ile Ala Tyr Lys Arg His Lys Asp Ala Arg Arg Lys Gln Met 
        835                 840                 845             


Gln Leu Ala Phe Ala Ala Val Asn Val Trp Arg Lys Asn Leu Gln Asp 
    850                 855                 860                 


Arg Lys Ser Gly Arg Ala Glu Pro Asp Pro Lys Lys Lys Ala Thr Phe 
865                 870                 875                 880 


Arg Ala Ile Thr Ser Thr Leu Ala Ser Ser Phe Lys Arg Arg Arg Ser 
                885                 890                 895     


Ser Lys Asp Thr Ser Thr Gly Gly Gly Arg Gly Ala Leu Gln Asn Gln 
            900                 905                 910         


Lys Asp Thr Val Leu Pro Arg Arg Ala Ile Glu Arg Glu Glu Gly Gln 
        915                 920                 925             


Leu Gln Leu Cys Ser Arg His Arg Glu Ser 
    930                 935             


<210>  3688
<211>  1119
<212>  PRT
<213>  Homo sapiens

<400>  3688

Met Lys Arg Ser Leu Arg Lys Met Trp Arg Pro Gly Glu Lys Lys Glu 
1               5                   10                  15      


Pro Gln Gly Val Val Tyr Glu Asp Val Pro Asp Asp Thr Glu Asp Phe 
            20                  25                  30          


Lys Glu Ser Leu Lys Val Val Phe Glu Gly Ser Ala Tyr Gly Leu Gln 
        35                  40                  45              


Asn Phe Asn Lys Gln Lys Lys Leu Lys Arg Cys Asp Asp Met Asp Thr 
    50                  55                  60                  


Phe Phe Leu His Tyr Ala Ala Ala Glu Gly Gln Ile Glu Leu Met Glu 
65                  70                  75                  80  


Lys Ile Thr Arg Asp Ser Ser Leu Glu Val Leu His Glu Met Asp Asp 
                85                  90                  95      


Tyr Gly Asn Thr Pro Leu His Cys Ala Val Glu Lys Asn Gln Ile Glu 
            100                 105                 110         


Ser Val Lys Phe Leu Leu Ser Arg Gly Ala Asn Pro Asn Leu Arg Asn 
        115                 120                 125             


Phe Asn Met Met Ala Pro Leu His Ile Ala Val Gln Gly Met Asn Asn 
    130                 135                 140                 


Glu Val Met Lys Val Leu Leu Glu His Arg Thr Ile Asp Val Asn Leu 
145                 150                 155                 160 


Glu Gly Glu Asn Gly Asn Thr Ala Val Ile Ile Ala Cys Thr Thr Asn 
                165                 170                 175     


Asn Ser Glu Ala Leu Gln Ile Leu Leu Lys Lys Gly Ala Lys Pro Cys 
            180                 185                 190         


Lys Ser Asn Lys Trp Gly Cys Phe Pro Ile His Gln Ala Ala Phe Ser 
        195                 200                 205             


Gly Ser Lys Glu Cys Met Glu Ile Ile Leu Arg Phe Gly Glu Glu His 
    210                 215                 220                 


Gly Tyr Ser Arg Gln Leu His Ile Asn Phe Met Asn Asn Gly Lys Ala 
225                 230                 235                 240 


Thr Pro Leu His Leu Ala Val Gln Asn Gly Asp Leu Glu Met Ile Lys 
                245                 250                 255     


Met Cys Leu Asp Asn Gly Ala Gln Ile Asp Pro Val Glu Lys Gly Arg 
            260                 265                 270         


Cys Thr Ala Ile His Phe Ala Ala Thr Gln Gly Ala Thr Glu Ile Val 
        275                 280                 285             


Lys Leu Met Ile Ser Ser Tyr Ser Gly Ser Val Asp Ile Val Asn Thr 
    290                 295                 300                 


Thr Asp Gly Cys His Glu Thr Met Leu His Arg Ala Ser Leu Phe Asp 
305                 310                 315                 320 


His His Glu Leu Ala Asp Tyr Leu Ile Ser Val Gly Ala Asp Ile Asn 
                325                 330                 335     


Lys Ile Asp Ser Glu Gly Arg Ser Pro Leu Ile Leu Ala Thr Ala Ser 
            340                 345                 350         


Ala Ser Trp Asn Ile Val Asn Leu Leu Leu Ser Lys Gly Ala Gln Val 
        355                 360                 365             


Asp Ile Lys Asp Asn Phe Gly Arg Asn Phe Leu His Leu Thr Val Gln 
    370                 375                 380                 


Gln Pro Tyr Gly Leu Lys Asn Leu Arg Pro Glu Phe Met Gln Met Gln 
385                 390                 395                 400 


Gln Ile Lys Glu Leu Val Met Asp Glu Asp Asn Asp Gly Cys Thr Pro 
                405                 410                 415     


Leu His Tyr Ala Cys Arg Gln Gly Gly Pro Gly Ser Val Asn Asn Leu 
            420                 425                 430         


Leu Gly Phe Asn Val Ser Ile His Ser Lys Ser Lys Asp Lys Lys Ser 
        435                 440                 445             


Pro Leu His Phe Ala Ala Ser Tyr Gly Arg Ile Asn Thr Cys Gln Arg 
    450                 455                 460                 


Leu Leu Gln Asp Ile Ser Asp Thr Arg Leu Leu Asn Glu Gly Asp Leu 
465                 470                 475                 480 


His Gly Met Thr Pro Leu His Leu Ala Ala Lys Asn Gly His Asp Lys 
                485                 490                 495     


Val Val Gln Leu Leu Leu Lys Lys Gly Ala Leu Phe Leu Ser Asp His 
            500                 505                 510         


Asn Gly Trp Thr Ala Leu His His Ala Ser Met Gly Gly Tyr Thr Gln 
        515                 520                 525             


Thr Met Lys Val Ile Leu Asp Thr Asn Leu Lys Cys Thr Asp Arg Leu 
    530                 535                 540                 


Asp Glu Asp Gly Asn Thr Ala Leu His Phe Ala Ala Arg Glu Gly His 
545                 550                 555                 560 


Ala Lys Ala Val Ala Leu Leu Leu Ser His Asn Ala Asp Ile Val Leu 
                565                 570                 575     


Asn Lys Gln Gln Ala Ser Phe Leu His Leu Ala Leu His Asn Lys Arg 
            580                 585                 590         


Lys Glu Val Val Leu Thr Ile Ile Arg Ser Lys Arg Trp Asp Glu Cys 
        595                 600                 605             


Leu Lys Ile Phe Ser His Asn Ser Pro Gly Asn Lys Cys Pro Ile Thr 
    610                 615                 620                 


Glu Met Ile Glu Tyr Leu Pro Glu Cys Met Lys Val Leu Leu Asp Phe 
625                 630                 635                 640 


Cys Met Leu His Ser Thr Glu Asp Lys Ser Cys Arg Asp Tyr Tyr Ile 
                645                 650                 655     


Glu Tyr Asn Phe Lys Tyr Leu Gln Cys Pro Leu Glu Phe Thr Lys Lys 
            660                 665                 670         


Thr Pro Thr Gln Asp Val Ile Tyr Glu Pro Leu Thr Ala Leu Asn Ala 
        675                 680                 685             


Met Val Gln Asn Asn Arg Ile Glu Leu Leu Asn His Pro Val Cys Lys 
    690                 695                 700                 


Glu Tyr Leu Leu Met Lys Trp Leu Ala Tyr Gly Phe Arg Ala His Met 
705                 710                 715                 720 


Met Asn Leu Gly Ser Tyr Cys Leu Gly Leu Ile Pro Met Thr Ile Leu 
                725                 730                 735     


Val Val Asn Ile Lys Pro Gly Met Ala Phe Asn Ser Thr Gly Ile Ile 
            740                 745                 750         


Asn Glu Thr Ser Asp His Ser Glu Ile Leu Asp Thr Thr Asn Ser Tyr 
        755                 760                 765             


Leu Ile Lys Thr Cys Met Ile Leu Val Phe Leu Ser Ser Ile Phe Gly 
    770                 775                 780                 


Tyr Cys Lys Glu Ala Gly Gln Ile Phe Gln Gln Lys Arg Asn Tyr Phe 
785                 790                 795                 800 


Met Asp Ile Ser Asn Val Leu Glu Trp Ile Ile Tyr Thr Thr Gly Ile 
                805                 810                 815     


Ile Phe Val Leu Pro Leu Phe Val Glu Ile Pro Ala His Leu Gln Trp 
            820                 825                 830         


Gln Cys Gly Ala Ile Ala Val Tyr Phe Tyr Trp Met Asn Phe Leu Leu 
        835                 840                 845             


Tyr Leu Gln Arg Phe Glu Asn Cys Gly Ile Phe Ile Val Met Leu Glu 
    850                 855                 860                 


Val Ile Leu Lys Thr Leu Leu Arg Ser Thr Val Val Phe Ile Phe Leu 
865                 870                 875                 880 


Leu Leu Ala Phe Gly Leu Ser Phe Tyr Ile Leu Leu Asn Leu Gln Asp 
                885                 890                 895     


Pro Phe Ser Ser Pro Leu Leu Ser Ile Ile Gln Thr Phe Ser Met Met 
            900                 905                 910         


Leu Gly Asp Ile Asn Tyr Arg Glu Ser Phe Leu Glu Pro Tyr Leu Arg 
        915                 920                 925             


Asn Glu Leu Ala His Pro Val Leu Ser Phe Ala Gln Leu Val Ser Phe 
    930                 935                 940                 


Thr Ile Phe Val Pro Ile Val Leu Met Asn Leu Leu Ile Gly Leu Ala 
945                 950                 955                 960 


Val Gly Asp Ile Ala Glu Val Gln Lys His Ala Ser Leu Lys Arg Ile 
                965                 970                 975     


Ala Met Gln Val Glu Leu His Thr Ser Leu Glu Lys Lys Leu Pro Leu 
            980                 985                 990         


Trp Phe Leu Arg Lys Val Asp Gln  Lys Ser Thr Ile Val  Tyr Pro Asn 
        995                 1000                 1005             


Lys Pro  Arg Ser Gly Gly Met  Leu Phe His Ile Phe  Cys Phe Leu 
    1010                 1015                 1020             


Phe Cys  Thr Gly Glu Ile Arg  Gln Glu Ile Pro Asn  Ala Asp Lys 
    1025                 1030                 1035             


Ser Leu  Glu Met Glu Ile Leu  Lys Gln Lys Tyr Arg  Leu Lys Asp 
    1040                 1045                 1050             


Leu Thr  Phe Leu Leu Glu Lys  Gln His Glu Leu Ile  Lys Leu Ile 
    1055                 1060                 1065             


Ile Gln  Lys Met Glu Ile Ile  Ser Glu Thr Glu Asp  Asp Asp Ser 
    1070                 1075                 1080             


His Cys  Ser Phe Gln Asp Arg  Phe Lys Lys Glu Gln  Met Glu Gln 
    1085                 1090                 1095             


Arg Asn  Ser Arg Trp Asn Thr  Val Leu Arg Ala Val  Lys Ala Lys 
    1100                 1105                 1110             


Thr His  His Leu Glu Pro 
    1115                 


<210>  3689
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  3689

Met Ser Lys Gln Arg Gly Thr Phe Ser Glu Val Ser Leu Ala Gln Asp 
1               5                   10                  15      


Pro Lys Trp Gln Gln Arg Lys Pro Lys Gly Asn Lys Ser Ser Ile Ser 
            20                  25                  30          


Gly Thr Glu Gln Glu Ile Phe Gln Val Glu Leu Asn Leu Gln Asn Ala 
        35                  40                  45              


Ser Leu Asn His Gln Gly Ile Asp Lys Ile Tyr Asp Cys Gln Gly Leu 
    50                  55                  60                  


Leu Pro Pro Pro Glu Lys Leu Thr Ala Glu Val Leu Gly Ile Ile Cys 
65                  70                  75                  80  


Ile Val Leu Met Ala Thr Val Leu Lys Thr Ile Val Leu Ile Pro Phe 
                85                  90                  95      


Leu Glu Gln Asn Asn Ser Ser Pro Asn Ala Arg Thr Gln Lys Ala Arg 
            100                 105                 110         


His Cys Gly His Cys Pro Glu Glu Trp Ile Thr Tyr Ser Asn Ser Cys 
        115                 120                 125             


Tyr Tyr Ile Gly Lys Glu Arg Arg Thr Trp Glu Glu Ser Leu Gln Ala 
    130                 135                 140                 


Cys Ala Ser Lys Asn Ser Ser Ser Leu Leu Cys Ile Asp Asn Glu Glu 
145                 150                 155                 160 


Glu Met Lys Phe Leu Ala Ser Ile Leu Pro Ser Ser Trp Ile Gly Val 
                165                 170                 175     


Phe Arg Asn Ser Ser His His Pro Trp Val Thr Ile Asn Gly Leu Ala 
            180                 185                 190         


Phe Lys His Glu Ile Lys Asp Ser Asp His Ala Glu Arg Asn Cys Ala 
        195                 200                 205             


Met Leu His Val Arg Gly Leu Ile Ser Asp Gln Cys Gly Ser Ser Arg 
    210                 215                 220                 


Ile Ile Val Ser Ile Ser Phe Arg Ile Lys Ala Leu Glu Leu Ala Val 
225                 230                 235                 240 


His Gln Ile Lys Phe Tyr Ile Cys Ser Asn Arg Asn Asp Ile Met Ile 
                245                 250                 255     


Ala 
    


<210>  3690
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  3690

Met Ala Ala Phe Thr Lys Leu Ser Ile Glu Pro Ala Phe Thr Pro Gly 
1               5                   10                  15      


Pro Asn Ile Glu Leu Gln Lys Asp Ser Asp Cys Cys Ser Cys Gln Glu 
            20                  25                  30          


Lys Trp Val Gly Tyr Arg Cys Asn Cys Tyr Phe Ile Ser Ser Glu Gln 
        35                  40                  45              


Lys Thr Trp Asn Glu Ser Arg His Leu Cys Ala Ser Gln Lys Ser Ser 
    50                  55                  60                  


Leu Leu Gln Leu Gln Asn Thr Asp Glu Leu Asp Phe Met Ser Ser Ser 
65                  70                  75                  80  


Gln Gln Phe Tyr Trp Ile Gly Leu Ser Tyr Ser Glu Glu His Thr Ala 
                85                  90                  95      


Trp Leu Trp Glu Asn Gly Ser Ala Leu Ser Gln Tyr Leu Phe Pro Ser 
            100                 105                 110         


Phe Glu Thr Phe Asn Thr Lys Asn Cys Ile Ala Tyr Asn Pro Asn Gly 
        115                 120                 125             


Asn Ala Leu Asp Glu Ser Cys Glu Asp Lys Asn Arg Tyr Ile Cys Lys 
    130                 135                 140                 


Gln Gln Leu Ile 
145             


<210>  3691
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  3691

Met Gly Ser Thr Val Pro Arg Ser Ala Ser Val Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Arg Arg Ala Glu Gln Pro Cys Gly Ala Glu Leu Thr Phe Glu 
            20                  25                  30          


Leu Pro Asp Asn Ala Lys Gln Cys Phe His Glu Glu Val Glu Gln Gly 
        35                  40                  45              


Val Lys Phe Ser Leu Asp Tyr Gln Val Ile Thr Gly Gly His Tyr Asp 
    50                  55                  60                  


Val Asp Cys Tyr Val Glu Asp Pro Gln Gly Asn Thr Ile Tyr Arg Glu 
65                  70                  75                  80  


Thr Lys Lys Gln Tyr Asp Ser Phe Thr Tyr Arg Ala Glu Val Lys Gly 
                85                  90                  95      


Val Tyr Gln Phe Cys Phe Ser Asn Glu Phe Ser Thr Phe Ser His Lys 
            100                 105                 110         


Thr Val Tyr Phe Asp Phe Gln Val Gly Asp Glu Pro Pro Ile Leu Pro 
        115                 120                 125             


Asp Met Gly Asn Arg Val Thr Ala Leu Thr Gln Met Glu Ser Ala Cys 
    130                 135                 140                 


Val Thr Ile His Glu Ala Leu Lys Thr Val Ile Asp Ser Gln Thr His 
145                 150                 155                 160 


Tyr Arg Leu Arg Glu Ala Gln Asp Arg Ala Arg Ala Glu Asp Leu Asn 
                165                 170                 175     


Ser Arg Val Ser Tyr Trp Ser Val Gly Glu Thr Ile Ala Leu Phe Val 
            180                 185                 190         


Val Ser Phe Ser Gln Val Leu Leu Leu Lys Ser Phe Phe Thr Glu Lys 
        195                 200                 205             


Arg Pro Ile Ser Arg Ala Val His Ser 
    210                 215         


<210>  3692
<211>  1463
<212>  PRT
<213>  Homo sapiens

<400>  3692

Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro 
1               5                   10                  15      


Arg Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro Glu Arg Leu 
            20                  25                  30          


Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu 
        35                  40                  45              


Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys 
    50                  55                  60                  


Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly 
65                  70                  75                  80  


Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala 
                85                  90                  95      


Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser 
            100                 105                 110         


Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr 
        115                 120                 125             


Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr 
    130                 135                 140                 


Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu 
145                 150                 155                 160 


Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His Gly Met 
                165                 170                 175     


Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys 
            180                 185                 190         


Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser 
        195                 200                 205             


Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser 
    210                 215                 220                 


Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His 
225                 230                 235                 240 


Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala 
                245                 250                 255     


His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp 
            260                 265                 270         


Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys Thr Val 
        275                 280                 285             


Glu Val Trp Met Gly Leu Asn Gln Leu Asp Glu His Ala Gly Trp Gln 
    290                 295                 300                 


Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val 
305                 310                 315                 320 


Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe 
                325                 330                 335     


Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr 
            340                 345                 350         


Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val Glu Lys 
        355                 360                 365             


Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro 
    370                 375                 380                 


Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp His 
385                 390                 395                 400 


Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile Asp Ile 
                405                 410                 415     


Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu 
            420                 425                 430         


Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val 
        435                 440                 445             


Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn Trp His 
    450                 455                 460                 


Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser 
465                 470                 475                 480 


Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu Glu Arg 
                485                 490                 495     


Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser Asp Ala Glu 
            500                 505                 510         


Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys 
        515                 520                 525             


Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly Tyr Tyr 
    530                 535                 540                 


Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln Ala Phe 
545                 550                 555                 560 


Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp Ser Tyr Phe 
                565                 570                 575     


Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys 
            580                 585                 590         


Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp Asn Thr 
        595                 600                 605             


His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly Arg His 
    610                 615                 620                 


Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys Ala Met 
625                 630                 635                 640 


Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala Glu Tyr Glu 
                645                 650                 655     


Glu Arg Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser Glu Pro 
            660                 665                 670         


Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met 
        675                 680                 685             


Lys Arg Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala 
    690                 695                 700                 


His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu 
705                 710                 715                 720 


Leu Leu His Ser Lys Phe Asn Trp Thr Glu Glu Arg Gln Phe Trp Ile 
                725                 730                 735     


Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu Trp Ser 
            740                 745                 750         


Asp Arg Thr Pro Val Val Ser Ser Phe Leu Asp Asn Thr Tyr Phe Gly 
        755                 760                 765             


Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu 
    770                 775                 780                 


Pro Leu His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile Pro Arg 
785                 790                 795                 800 


Asp Val Lys Pro Lys Ile Pro Phe Trp Tyr Gln Tyr Asp Val Pro Trp 
                805                 810                 815     


Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Thr Phe Ala Ser Glu 
            820                 825                 830         


Trp Leu Asn Phe Glu Phe Val Cys Ser Trp Leu His Ser Asp Leu Leu 
        835                 840                 845             


Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser Lys Ile Lys 
    850                 855                 860                 


Ala Leu Ser Lys Tyr Gly Ala Ser Trp Trp Ile Gly Leu Gln Glu Glu 
865                 870                 875                 880 


Arg Ala Asn Asp Glu Phe Arg Trp Arg Asp Gly Thr Pro Val Ile Tyr 
                885                 890                 895     


Gln Asn Trp Asp Thr Gly Arg Glu Arg Thr Val Asn Asn Gln Ser Gln 
            900                 905                 910         


Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly Ser Glu Glu 
        915                 920                 925             


Cys Ser Val Ser Met Pro Ser Ile Cys Lys Arg Lys Lys Val Trp Leu 
    930                 935                 940                 


Ile Glu Lys Lys Lys Asp Thr Pro Lys Gln His Gly Thr Cys Pro Lys 
945                 950                 955                 960 


Gly Trp Leu Tyr Phe Asn Tyr Lys Cys Leu Leu Leu Asn Ile Pro Lys 
                965                 970                 975     


Asp Pro Ser Ser Trp Lys Asn Trp Thr His Ala Gln His Phe Cys Ala 
            980                 985                 990         


Glu Glu Gly Gly Thr Leu Val Ala  Ile Glu Ser Glu Val  Glu Gln Ala 
        995                 1000                 1005             


Phe Ile  Thr Met Asn Leu Phe  Gly Gln Thr Thr Ser  Val Trp Ile 
    1010                 1015                 1020             


Gly Leu  Gln Asn Asp Asp Tyr  Glu Thr Trp Leu Asn  Gly Lys Pro 
    1025                 1030                 1035             


Val Val  Tyr Ser Asn Trp Ser  Pro Phe Asp Ile Ile  Asn Ile Pro 
    1040                 1045                 1050             


Ser His  Asn Thr Thr Glu Val  Gln Lys His Ile Pro  Leu Cys Ala 
    1055                 1060                 1065             


Leu Leu  Ser Ser Asn Pro Asn  Phe His Phe Thr Gly  Lys Trp Tyr 
    1070                 1075                 1080             


Phe Glu  Asp Cys Gly Lys Glu  Gly Tyr Gly Phe Val  Cys Glu Lys 
    1085                 1090                 1095             


Met Gln  Asp Thr Ser Gly His  Gly Val Asn Thr Ser  Asp Met Tyr 
    1100                 1105                 1110             


Pro Met  Pro Asn Thr Leu Glu  Tyr Gly Asn Arg Thr  Tyr Lys Ile 
    1115                 1120                 1125             


Ile Asn  Ala Asn Met Thr Trp  Tyr Ala Ala Ile Lys  Thr Cys Leu 
    1130                 1135                 1140             


Met His  Lys Ala Gln Leu Val  Ser Ile Thr Asp Gln  Tyr His Gln 
    1145                 1150                 1155             


Ser Phe  Leu Thr Val Val Leu  Asn Arg Leu Gly Tyr  Ala His Trp 
    1160                 1165                 1170             


Ile Gly  Leu Phe Thr Thr Asp  Asn Gly Leu Asn Phe  Asp Trp Ser 
    1175                 1180                 1185             


Asp Gly  Thr Lys Ser Ser Phe  Thr Phe Trp Lys Asp  Glu Glu Ser 
    1190                 1195                 1200             


Ser Leu  Leu Gly Asp Cys Val  Phe Ala Asp Ser Asn  Gly Arg Trp 
    1205                 1210                 1215             


His Ser  Thr Ala Cys Glu Ser  Phe Leu Gln Gly Ala  Ile Cys His 
    1220                 1225                 1230             


Val Pro  Pro Glu Thr Arg Gln  Ser Glu His Pro Glu  Leu Cys Ser 
    1235                 1240                 1245             


Glu Thr  Ser Ile Pro Trp Ile  Lys Phe Lys Ser Asn  Cys Tyr Ser 
    1250                 1255                 1260             


Phe Ser  Thr Val Leu Asp Ser  Met Ser Phe Glu Ala  Ala His Glu 
    1265                 1270                 1275             


Phe Cys  Lys Lys Glu Gly Ser  Asn Leu Leu Thr Ile  Lys Asp Glu 
    1280                 1285                 1290             


Ala Glu  Asn Ala Phe Leu Leu  Glu Glu Leu Phe Ala  Phe Gly Ser 
    1295                 1300                 1305             


Ser Val  Gln Met Val Trp Leu  Asn Ala Gln Phe Asp  Gly Asn Asn 
    1310                 1315                 1320             


Glu Thr  Ile Lys Trp Phe Asp  Gly Thr Pro Thr Asp  Gln Ser Asn 
    1325                 1330                 1335             


Trp Gly  Ile Arg Lys Pro Asp  Thr Asp Tyr Phe Lys  Pro His His 
    1340                 1345                 1350             


Cys Val  Ala Leu Arg Ile Pro  Glu Gly Leu Trp Gln  Leu Ser Pro 
    1355                 1360                 1365             


Cys Gln  Glu Lys Lys Gly Phe  Ile Cys Lys Met Glu  Ala Asp Ile 
    1370                 1375                 1380             


His Thr  Ala Glu Ala Leu Pro  Glu Lys Gly Pro Ser  His Ser Ile 
    1385                 1390                 1395             


Ile Pro  Leu Ala Val Val Leu  Thr Leu Ile Val Ile  Val Ala Ile 
    1400                 1405                 1410             


Cys Thr  Leu Ser Phe Cys Ile  Tyr Lys His Asn Gly  Gly Phe Phe 
    1415                 1420                 1425             


Arg Arg  Leu Ala Gly Phe Arg  Asn Pro Tyr Tyr Pro  Ala Thr Asn 
    1430                 1435                 1440             


Phe Ser  Thr Val Tyr Leu Glu  Glu Asn Ile Leu Ile  Ser Asp Leu 
    1445                 1450                 1455             


Glu Lys  Ser Asp Gln 
    1460             


<210>  3693
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  3693

Met Ile Leu Asn Ser Ser Thr Glu Asp Gly Ile Lys Arg Ile Gln Asp 
1               5                   10                  15      


Asp Cys Pro Lys Ala Gly Arg His Asn Tyr Ile Phe Val Met Ile Pro 
            20                  25                  30          


Thr Leu Tyr Ser Ile Ile Phe Val Val Gly Ile Phe Gly Asn Ser Leu 
        35                  40                  45              


Val Val Ile Val Ile Tyr Phe Tyr Met Lys Leu Lys Thr Val Ala Ser 
    50                  55                  60                  


Val Phe Leu Leu Asn Leu Ala Leu Ala Asp Leu Cys Phe Leu Leu Thr 
65                  70                  75                  80  


Leu Pro Leu Trp Ala Val Tyr Thr Ala Met Glu Tyr Arg Trp Pro Phe 
                85                  90                  95      


Gly Asn Tyr Leu Cys Lys Ile Ala Ser Ala Ser Val Ser Phe Asn Leu 
            100                 105                 110         


Tyr Ala Ser Val Phe Leu Leu Thr Cys Leu Ser Ile Asp Arg Tyr Leu 
        115                 120                 125             


Ala Ile Val His Pro Met Lys Ser Arg Leu Arg Arg Thr Met Leu Val 
    130                 135                 140                 


Ala Lys Val Thr Cys Ile Ile Ile Trp Leu Leu Ala Gly Leu Ala Ser 
145                 150                 155                 160 


Leu Pro Ala Ile Ile His Arg Asn Val Phe Phe Ile Glu Asn Thr Asn 
                165                 170                 175     


Ile Thr Val Cys Ala Phe His Tyr Glu Ser Gln Asn Ser Thr Leu Pro 
            180                 185                 190         


Ile Gly Leu Gly Leu Thr Lys Asn Ile Leu Gly Phe Leu Phe Pro Phe 
        195                 200                 205             


Leu Ile Ile Leu Thr Ser Tyr Thr Leu Ile Trp Lys Ala Leu Lys Lys 
    210                 215                 220                 


Ala Tyr Glu Ile Gln Lys Asn Lys Pro Arg Asn Asp Asp Ile Phe Lys 
225                 230                 235                 240 


Ile Ile Met Ala Ile Val Leu Phe Phe Phe Phe Ser Trp Ile Pro His 
                245                 250                 255     


Gln Ile Phe Thr Phe Leu Asp Val Leu Ile Gln Leu Gly Ile Ile Arg 
            260                 265                 270         


Asp Cys Arg Ile Ala Asp Ile Val Asp Thr Ala Met Pro Ile Thr Ile 
        275                 280                 285             


Cys Ile Ala Tyr Phe Asn Asn Cys Leu Asn Pro Leu Phe Tyr Gly Phe 
    290                 295                 300                 


Leu Gly Lys Lys Phe Lys Arg Tyr Phe Leu Gln Leu Leu Lys Tyr Ile 
305                 310                 315                 320 


Pro Pro Lys Ala Lys Ser His Ser Asn Leu Ser Thr Lys Met Ser Thr 
                325                 330                 335     


Leu Ser Tyr Arg Pro Ser Asp Asn Val Ser Ser Ser Thr Lys Lys Pro 
            340                 345                 350         


Ala Pro Cys Phe Glu Val Glu 
        355                 


<210>  3694
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  3694

Met Gly Ala Leu Gly Leu Glu Gly Arg Gly Gly Arg Leu Gln Gly Arg 
1               5                   10                  15      


Gly Ser Leu Leu Leu Ala Val Ala Gly Ala Thr Ser Leu Val Thr Leu 
            20                  25                  30          


Leu Leu Ala Val Pro Ile Thr Val Leu Ala Val Leu Ala Leu Val Pro 
        35                  40                  45              


Gln Asp Gln Gly Gly Leu Gly Phe Arg Ser Cys Gln Arg Arg Ser Gln 
    50                  55                  60                  


Lys Gln Ile Ser Ala Pro Gly Ser Gln Leu Pro Thr Ser 
65                  70                  75          


<210>  3695
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  3695

Met Arg Ser Ala Ala Arg Arg Gly Arg Ala Ala Pro Ala Ala Arg Asp 
1               5                   10                  15      


Ser Leu Pro Val Leu Leu Phe Leu Cys Leu Leu Leu Lys Thr Cys Glu 
            20                  25                  30          


Pro Lys Thr Ala Asn Ala Phe Lys Pro Asn Ile Leu Leu Ile Met Ala 
        35                  40                  45              


Asp Asp Leu Gly Thr Gly Asp Leu Gly Cys Tyr Gly Asn Asn Thr Leu 
    50                  55                  60                  


Arg Thr Pro Asn Ile Asp Gln Leu Ala Glu Glu Gly Val Arg Leu Thr 
65                  70                  75                  80  


Gln His Leu Ala Ala Ala Pro Leu Cys Thr Pro Ser Arg Ala Ala Phe 
                85                  90                  95      


Leu Thr Gly Arg His Ser Phe Arg Ser Gly Met Asp Ala Ser Asn Gly 
            100                 105                 110         


Tyr Arg Ala Leu Gln Trp Asn Ala Gly Ser Gly Gly Leu Pro Glu Asn 
        115                 120                 125             


Glu Thr Thr Phe Ala Arg Ile Leu Gln Gln His Gly Tyr Ala Thr Gly 
    130                 135                 140                 


Leu Ile Gly Lys Trp His Gln Gly Val Asn Cys Ala Ser Arg Gly Asp 
145                 150                 155                 160 


His Cys His His Pro Leu Asn His Gly Phe Asp Tyr Phe Tyr Gly Met 
                165                 170                 175     


Pro Phe Thr Leu Thr Asn Asp Cys Asp Pro Gly Arg Pro Pro Glu Val 
            180                 185                 190         


Asp Ala Ala Leu Arg Ala Gln Leu Trp Gly Tyr Thr Gln Phe Leu Ala 
        195                 200                 205             


Leu Gly Ile Leu Thr Leu Ala Ala Gly Gln Thr Cys Gly Phe Phe Ser 
    210                 215                 220                 


Val Ser Ala Arg Ala Val Thr Gly Met Ala Gly Val Gly Cys Leu Phe 
225                 230                 235                 240 


Phe Ile Ser Trp Tyr Ser Ser Phe Gly Phe Val Arg Arg Trp Asn Cys 
                245                 250                 255     


Ile Leu Met Arg Asn His Asp Val Thr Glu Gln Pro Met Val Leu Glu 
            260                 265                 270         


Lys Thr Ala Ser Leu Met Leu Lys Glu Ala Val Ser Tyr Ile Glu Arg 
        275                 280                 285             


His Lys His Gly Pro Phe Leu Leu Phe Leu Ser Leu Leu His Val His 
    290                 295                 300                 


Ile Pro Leu Val Thr Thr Ser Ala Phe Leu Gly Lys Ser Gln His Gly 
305                 310                 315                 320 


Leu Tyr Gly Asp Asn Val Glu Glu Met Asp Trp Leu Ile Ala Ser Asp 
                325                 330                 335     


Phe Met Ser Ser Ser Glu Val Thr Glu Ser Glu Ala Ile Lys Leu Met 
            340                 345                 350         


Phe Arg Thr Met Gln Thr Arg Cys Leu Pro Ser Met Ala Phe Lys Lys 
        355                 360                 365             


Pro Trp Arg Gly Pro Val Arg Leu Gln Ile Leu Lys Arg Ala 
    370                 375                 380         


<210>  3696
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  3696

Met Trp Glu Leu Arg Ser Ala Ser Phe Trp Arg Ala Ile Phe Ala Glu 
1               5                   10                  15      


Phe Phe Ala Thr Leu Phe Tyr Val Phe Phe Gly Leu Gly Ser Ser Leu 
            20                  25                  30          


Arg Trp Ala Pro Gly Pro Leu His Val Leu Gln Val Ala Met Ala Phe 
        35                  40                  45              


Gly Leu Ala Leu Ala Thr Leu Val Gln Ser Val Gly His Ile Ser Gly 
    50                  55                  60                  


Ala His Val Asn Pro Ala Val Thr Phe Ala Phe Leu Val Gly Ser Gln 
65                  70                  75                  80  


Met Ser Leu Leu Arg Ala Phe Cys Tyr Met Ala Ala Gln Leu Leu Gly 
                85                  90                  95      


Ala Val Ala Gly Ala Ala Val Leu Tyr Ser Val Thr Pro Pro Ala Val 
            100                 105                 110         


Arg Gly Asn Leu Ala Leu Asn Thr Leu His Pro Ala Val Ser Val Gly 
        115                 120                 125             


Gln Ala Thr Thr Val Glu Ile Phe Leu Thr Leu Gln Phe Val Leu Cys 
    130                 135                 140                 


Ile Phe Ala Thr Tyr Asp Glu Arg Arg Asn Gly Gln Leu Gly Ser Val 
145                 150                 155                 160 


Ala Leu Ala Val Gly Phe Ser Leu Ala Leu Gly His Leu Phe Gly Met 
                165                 170                 175     


Tyr Tyr Thr Gly Ala Gly Met Asn Pro Ala Arg Ser Phe Ala Pro Ala 
            180                 185                 190         


Ile Leu Thr Gly Asn Phe Thr Asn His Trp Val Tyr Trp Val Gly Pro 
        195                 200                 205             


Ile Ile Gly Gly Gly Leu Gly Ser Leu Leu Tyr Asp Phe Leu Leu Phe 
    210                 215                 220                 


Pro Arg Leu Lys Ser Ile Ser Glu Arg Leu Ser Val Leu Lys Gly Ala 
225                 230                 235                 240 


Lys Pro Asp Val Ser Asn Gly Gln Pro Glu Val Thr Gly Glu Pro Val 
                245                 250                 255     


Glu Leu Asn Thr Gln Ala Leu 
            260             


<210>  3697
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  3697

Met Arg Arg Gln Leu Arg Ser Arg Arg Ala Pro Ser Phe Pro Tyr Ser 
1               5                   10                  15      


Tyr Arg Tyr Arg Leu Asp Asp Pro Asp Glu Ala Asn Gln Asn Tyr Leu 
            20                  25                  30          


Ala Asp Glu Glu Glu Glu Ala Glu Glu Glu Ala Arg Val Thr Val Val 
        35                  40                  45              


Pro Lys Ser Glu Glu Glu Glu Glu Glu Glu Glu Lys Glu Glu Glu Glu 
    50                  55                  60                  


Glu Glu Glu Lys Glu Glu Glu Glu Gly Gln Gly Gln Pro Thr Gly Asn 
65                  70                  75                  80  


Ala Trp Trp Gln Lys Leu Gln Ile Met Ser Glu Tyr Leu Trp Asp Pro 
                85                  90                  95      


Glu Arg Arg Met Phe Leu Ala Arg Thr Gly Leu Ile Leu Leu Ile Tyr 
            100                 105                 110         


Phe Phe Phe Tyr Ala Ser Leu Ala Ala Val Ile Thr Leu Cys Met Tyr 
        115                 120                 125             


Thr Leu Phe Leu Thr Ile Ser Pro Tyr Ile Pro Thr Phe Thr Glu Arg 
    130                 135                 140                 


Val Lys Pro Pro Gly Val Met Ile Arg Pro Phe Ala His Ser Leu Asn 
145                 150                 155                 160 


Phe Asn Phe Asn Val Ser Glu Pro Asp Thr Trp Gln His Tyr Val Ile 
                165                 170                 175     


Ser Leu Asn Gly Phe Leu Gln Gly Tyr Asn Asp Ser Leu Gln Glu Glu 
            180                 185                 190         


Met Asn Val Asp Cys Pro Pro Gly Gln Tyr Phe Ile Gln Asp Gly Asn 
        195                 200                 205             


Glu Asp Glu Asp Lys Lys Ala Cys Gln Phe Lys Arg Ser Phe Leu Lys 
    210                 215                 220                 


Asn Cys Ser Gly Leu Glu Asp Pro Thr Phe Gly Tyr Ser Thr Gly Gln 
225                 230                 235                 240 


Pro Cys Ile Leu Leu Lys Met Asn Arg Ile Val Gly Phe Arg Pro Glu 
                245                 250                 255     


Leu Gly Asp Pro Val Lys Val Ser Cys Lys Val Gln Arg Gly Asp Glu 
            260                 265                 270         


Asn Asp Ile Arg Ser Ile Ser Tyr Tyr Pro Glu Ser Ala Ser Phe Asp 
        275                 280                 285             


Leu Arg Tyr Tyr Pro Tyr Tyr Gly Lys Leu Thr His Val Asn Tyr Thr 
    290                 295                 300                 


Ser Pro Leu Val Ala Met His Phe Thr Asp Val Val Lys Asn Gln Ala 
305                 310                 315                 320 


Val Pro Val Gln Cys Gln Leu Lys Gly Lys Gly Val Ile Asn Asp Val 
                325                 330                 335     


Ile Asn Asp Arg Phe Val Gly Arg Val Ile Phe Thr Leu Asn Ile Glu 
            340                 345                 350         


Thr 
    


<210>  3698
<211>  652
<212>  PRT
<213>  Homo sapiens

<400>  3698

Met Ala Thr Ser Met Gly Leu Leu Leu Leu Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Gln Pro Gly Ala Gly Thr Gly Ala Asp Thr Glu Ala Val Val Cys Val 
            20                  25                  30          


Gly Thr Ala Cys Tyr Thr Ala His Ser Gly Lys Leu Ser Ala Ala Glu 
        35                  40                  45              


Ala Gln Asn His Cys Asn Gln Asn Gly Gly Asn Leu Ala Thr Val Lys 
    50                  55                  60                  


Ser Lys Glu Glu Ala Gln His Val Gln Arg Val Leu Ala Gln Leu Leu 
65                  70                  75                  80  


Arg Arg Glu Ala Ala Leu Thr Ala Arg Met Ser Lys Phe Trp Ile Gly 
                85                  90                  95      


Leu Gln Arg Glu Lys Gly Lys Cys Leu Asp Pro Ser Leu Pro Leu Lys 
            100                 105                 110         


Gly Phe Ser Trp Val Gly Gly Gly Glu Asp Thr Pro Tyr Ser Asn Trp 
        115                 120                 125             


His Lys Glu Leu Arg Asn Ser Cys Ile Ser Lys Arg Cys Val Ser Leu 
    130                 135                 140                 


Leu Leu Asp Leu Ser Gln Pro Leu Leu Pro Ser Arg Leu Pro Lys Trp 
145                 150                 155                 160 


Ser Glu Gly Pro Cys Gly Ser Pro Gly Ser Pro Gly Ser Asn Ile Glu 
                165                 170                 175     


Gly Phe Val Cys Lys Phe Ser Phe Lys Gly Met Cys Arg Pro Leu Ala 
            180                 185                 190         


Leu Gly Gly Pro Gly Gln Val Thr Tyr Thr Thr Pro Phe Gln Thr Thr 
        195                 200                 205             


Ser Ser Ser Leu Glu Ala Val Pro Phe Ala Ser Ala Ala Asn Val Ala 
    210                 215                 220                 


Cys Gly Glu Gly Asp Lys Asp Glu Thr Gln Ser His Tyr Phe Leu Cys 
225                 230                 235                 240 


Lys Glu Lys Ala Pro Asp Val Phe Asp Trp Gly Ser Ser Gly Pro Leu 
                245                 250                 255     


Cys Val Ser Pro Lys Tyr Gly Cys Asn Phe Asn Asn Gly Gly Cys His 
            260                 265                 270         


Gln Asp Cys Phe Glu Gly Gly Asp Gly Ser Phe Leu Cys Gly Cys Arg 
        275                 280                 285             


Pro Gly Phe Arg Leu Leu Asp Asp Leu Val Thr Cys Ala Ser Arg Asn 
    290                 295                 300                 


Pro Cys Ser Ser Ser Pro Cys Arg Gly Gly Ala Thr Cys Val Leu Gly 
305                 310                 315                 320 


Pro His Gly Lys Asn Tyr Thr Cys Arg Cys Pro Gln Gly Tyr Gln Leu 
                325                 330                 335     


Asp Ser Ser Gln Leu Asp Cys Val Asp Val Asp Glu Cys Gln Asp Ser 
            340                 345                 350         


Pro Cys Ala Gln Glu Cys Val Asn Thr Pro Gly Gly Phe Arg Cys Glu 
        355                 360                 365             


Cys Trp Val Gly Tyr Glu Pro Gly Gly Pro Gly Glu Gly Ala Cys Gln 
    370                 375                 380                 


Asp Val Asp Glu Cys Ala Leu Gly Arg Ser Pro Cys Ala Gln Gly Cys 
385                 390                 395                 400 


Thr Asn Thr Asp Gly Ser Phe His Cys Ser Cys Glu Glu Gly Tyr Val 
                405                 410                 415     


Leu Ala Gly Glu Asp Gly Thr Gln Cys Gln Asp Val Asp Glu Cys Val 
            420                 425                 430         


Gly Pro Gly Gly Pro Leu Cys Asp Ser Leu Cys Phe Asn Thr Gln Gly 
        435                 440                 445             


Ser Phe His Cys Gly Cys Leu Pro Gly Trp Val Leu Ala Pro Asn Gly 
    450                 455                 460                 


Val Ser Cys Thr Met Gly Pro Val Ser Leu Gly Pro Pro Ser Gly Pro 
465                 470                 475                 480 


Pro Asp Glu Glu Asp Lys Gly Glu Lys Glu Gly Ser Thr Val Pro Arg 
                485                 490                 495     


Ala Ala Thr Ala Ser Pro Thr Arg Gly Pro Glu Gly Thr Pro Lys Ala 
            500                 505                 510         


Thr Pro Thr Thr Ser Arg Pro Ser Leu Ser Ser Asp Ala Pro Ile Thr 
        515                 520                 525             


Ser Ala Pro Leu Lys Met Leu Ala Pro Ser Gly Ser Pro Gly Val Trp 
    530                 535                 540                 


Arg Glu Pro Ser Ile His His Ala Thr Ala Ala Ser Gly Pro Gln Glu 
545                 550                 555                 560 


Pro Ala Gly Gly Asp Ser Ser Val Ala Thr Gln Asn Asn Asp Gly Thr 
                565                 570                 575     


Asp Gly Gln Lys Leu Leu Leu Phe Tyr Ile Leu Gly Thr Val Val Ala 
            580                 585                 590         


Ile Leu Leu Leu Leu Ala Leu Ala Leu Gly Leu Leu Val Tyr Arg Lys 
        595                 600                 605             


Arg Arg Ala Lys Arg Glu Glu Lys Lys Glu Lys Lys Pro Gln Asn Ala 
    610                 615                 620                 


Ala Asp Ser Tyr Ser Trp Val Pro Glu Arg Ala Glu Ser Arg Ala Met 
625                 630                 635                 640 


Glu Asn Gln Tyr Ser Pro Thr Pro Gly Thr Asp Cys 
                645                 650         


<210>  3699
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  3699

Met Gly Asp Arg Gly Ser Ser Arg Arg Arg Arg Thr Gly Ser Arg Pro 
1               5                   10                  15      


Ser Ser His Gly Gly Gly Gly Pro Ala Ala Ala Glu Glu Glu Val Arg 
            20                  25                  30          


Asp Ala Ala Ala Gly Pro Asp Val Gly Ala Ala Gly Asp Ala Pro Ala 
        35                  40                  45              


Pro Ala Pro Asn Lys Asp Gly Asp Ala Gly Val Gly Ser Gly His Trp 
    50                  55                  60                  


Glu Leu Arg Cys His Arg Leu Gln Asp Ser Leu Phe Ser Ser Asp Ser 
65                  70                  75                  80  


Gly Phe Ser Asn Tyr Arg Gly Ile Leu Asn Trp Cys Val Val Met Leu 
                85                  90                  95      


Ile Leu Ser Asn Ala Arg Leu Phe Leu Glu Asn Leu Ile Lys Tyr Gly 
            100                 105                 110         


Ile Leu Val Asp Pro Ile Gln Val Val Ser Leu Phe Leu Lys Asp Pro 
        115                 120                 125             


Tyr Ser Trp Pro Ala Pro Cys Leu Val Ile Ala Ala Asn Val Phe Ala 
    130                 135                 140                 


Val Ala Ala Phe Gln Val Glu Lys Arg Leu Ala Val Gly Ala Leu Thr 
145                 150                 155                 160 


Glu Gln Ala Gly Leu Leu Leu His Val Ala Asn Leu Ala Thr Ile Leu 
                165                 170                 175     


Cys Phe Pro Ala Ala Val Val Leu Leu Val Glu Ser Ile Thr Pro Val 
            180                 185                 190         


Gly Ser Leu Leu Ala Leu Met Ala His Thr Ile Leu Phe Leu Lys Leu 
        195                 200                 205             


Phe Ser Tyr Arg Asp Val Asn Ser Trp Cys Arg Arg Ala Arg Ala Lys 
    210                 215                 220                 


Ala Ala Ser Ala Gly Lys Lys Ala Ser Ser Ala Ala Ala Pro His Thr 
225                 230                 235                 240 


Val Ser Tyr Pro Asp Asn Leu Thr Tyr Arg Asp Leu Tyr Tyr Phe Leu 
                245                 250                 255     


Phe Ala Pro Thr Leu Cys Tyr Glu Leu Asn Phe Pro Arg Ser Pro Arg 
            260                 265                 270         


Ile Arg Lys Arg Phe Leu Leu Arg Arg Ile Leu Glu Met Leu Phe Phe 
        275                 280                 285             


Thr Gln Leu Gln Val Gly Leu Ile Gln Gln Trp Met Val Pro Thr Ile 
    290                 295                 300                 


Gln Asn Ser Met Lys Pro Phe Lys Asp Met Asp Tyr Ser Arg Ile Ile 
305                 310                 315                 320 


Glu Arg Leu Leu Lys Leu Ala Val Pro Asn His Leu Ile Trp Leu Ile 
                325                 330                 335     


Phe Phe Tyr Trp Leu Phe His Ser Cys Leu Asn Ala Val Ala Glu Leu 
            340                 345                 350         


Met Gln Phe Gly Asp Arg Glu Phe Tyr Arg Asp Trp Trp Asn Ser Glu 
        355                 360                 365             


Ser Val Thr Tyr Phe Trp Gln Asn Trp Asn Ile Pro Val His Lys Trp 
    370                 375                 380                 


Cys Ile Arg His Phe Tyr Lys Pro Met Leu Arg Arg Gly Ser Ser Lys 
385                 390                 395                 400 


Trp Met Ala Arg Thr Gly Val Phe Leu Ala Ser Ala Phe Phe His Glu 
                405                 410                 415     


Tyr Leu Val Ser Val Pro Leu Arg Met Phe Arg Leu Trp Ala Phe Thr 
            420                 425                 430         


Gly Met Met Ala Gln Ile Pro Leu Ala Trp Phe Val Gly Arg Phe Phe 
        435                 440                 445             


Gln Gly Asn Tyr Gly Asn Ala Ala Val Trp Leu Ser Leu Ile Ile Gly 
    450                 455                 460                 


Gln Pro Ile Ala Val Leu Met Tyr Val His Asp Tyr Tyr Val Leu Asn 
465                 470                 475                 480 


Tyr Glu Ala Pro Ala Ala Glu Ala 
                485             


<210>  3700
<211>  886
<212>  PRT
<213>  Homo sapiens

<400>  3700

Met Ser Gly Phe Ser Pro Glu Leu Ile Asp Tyr Leu Glu Gly Lys Ile 
1               5                   10                  15      


Ser Phe Glu Glu Phe Glu Arg Arg Arg Glu Glu Arg Lys Thr Arg Glu 
            20                  25                  30          


Lys Lys Ser Leu Gln Glu Lys Gly Lys Leu Ser Ala Glu Glu Asn Pro 
        35                  40                  45              


Asp Asp Ser Glu Val Pro Ser Ser Ser Gly Ile Asn Ser Thr Lys Ser 
    50                  55                  60                  


Gln Asp Lys Asp Val Asn Glu Gly Glu Thr Ser Asp Gly Val Arg Lys 
65                  70                  75                  80  


Ser Val His Lys Val Phe Ala Ser Met Leu Gly Glu Asn Glu Asp Asp 
                85                  90                  95      


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Thr 
            100                 105                 110         


Pro Glu Gln Pro Thr Ala Gly Asp Val Phe Val Leu Glu Met Val Leu 
        115                 120                 125             


Asn Arg Glu Thr Lys Lys Met Met Lys Glu Lys Arg Pro Arg Ser Lys 
    130                 135                 140                 


Leu Pro Arg Ala Leu Arg Gly Leu Met Gly Glu Ala Asn Ile Arg Phe 
145                 150                 155                 160 


Ala Arg Gly Glu Arg Glu Glu Ala Ile Leu Met Cys Met Glu Ile Ile 
                165                 170                 175     


Arg Gln Ala Pro Leu Ala Tyr Glu Pro Phe Ser Thr Leu Ala Met Ile 
            180                 185                 190         


Tyr Glu Asp Gln Gly Asp Met Glu Lys Ser Leu Gln Phe Glu Leu Ile 
        195                 200                 205             


Ala Ala His Leu Asn Pro Ser Asp Thr Glu Glu Trp Val Arg Leu Ala 
    210                 215                 220                 


Glu Met Ser Leu Glu Gln Asp Asn Ile Lys Gln Ala Ile Phe Cys Tyr 
225                 230                 235                 240 


Thr Lys Ala Leu Lys Tyr Glu Pro Thr Asn Val Arg Tyr Leu Trp Glu 
                245                 250                 255     


Arg Ser Ser Leu Tyr Glu Gln Met Gly Asp His Lys Met Ala Met Asp 
            260                 265                 270         


Gly Tyr Arg Arg Ile Leu Asn Leu Leu Ser Pro Ser Asp Gly Glu Arg 
        275                 280                 285             


Phe Met Gln Leu Ala Arg Asp Met Ala Lys Ser Tyr Tyr Glu Ala Asn 
    290                 295                 300                 


Asp Val Thr Ser Ala Ile Asn Ile Ile Asp Glu Ala Phe Ser Lys His 
305                 310                 315                 320 


Gln Gly Leu Val Ser Met Glu Asp Val Asn Ile Ala Ala Glu Leu Tyr 
                325                 330                 335     


Ile Ser Asn Lys Gln Tyr Asp Lys Ala Leu Glu Ile Ile Thr Asp Phe 
            340                 345                 350         


Ser Gly Ile Val Leu Glu Lys Lys Thr Ser Glu Glu Gly Thr Ser Glu 
        355                 360                 365             


Glu Asn Lys Ala Pro Glu Asn Val Thr Cys Thr Ile Pro Asp Gly Val 
    370                 375                 380                 


Pro Ile Asp Ile Thr Val Lys Leu Met Val Cys Leu Val His Leu Asn 
385                 390                 395                 400 


Ile Leu Glu Pro Leu Asn Pro Leu Leu Thr Thr Leu Val Glu Gln Asn 
                405                 410                 415     


Pro Glu Asp Met Gly Asp Leu Tyr Leu Asp Val Ala Glu Ala Phe Leu 
            420                 425                 430         


Asp Val Gly Glu Tyr Asn Ser Ala Leu Pro Leu Leu Ser Ala Leu Val 
        435                 440                 445             


Cys Ser Glu Arg Tyr Asn Leu Ala Val Val Trp Leu Arg His Ala Glu 
    450                 455                 460                 


Cys Leu Lys Ala Leu Gly Tyr Met Glu Arg Ala Ala Glu Ser Tyr Gly 
465                 470                 475                 480 


Lys Val Val Asp Leu Ala Pro Leu His Leu Asp Ala Arg Ile Ser Leu 
                485                 490                 495     


Ser Thr Leu Gln Gln Gln Leu Gly Gln Pro Glu Lys Ala Leu Glu Ala 
            500                 505                 510         


Leu Glu Pro Met Tyr Asp Pro Asp Thr Leu Ala Gln Asp Ala Asn Ala 
        515                 520                 525             


Ala Gln Gln Glu Leu Lys Leu Leu Leu His Arg Ser Thr Leu Leu Phe 
    530                 535                 540                 


Ser Gln Gly Lys Met Tyr Gly Tyr Val Asp Thr Leu Leu Thr Met Leu 
545                 550                 555                 560 


Ala Met Leu Leu Lys Val Ala Met Asn Arg Ala Gln Val Cys Leu Ile 
                565                 570                 575     


Ser Ser Ser Lys Ser Gly Glu Arg His Leu Tyr Leu Ile Lys Val Ser 
            580                 585                 590         


Arg Asp Lys Ile Ser Asp Ser Asn Asp Gln Glu Ser Ala Asn Cys Asp 
        595                 600                 605             


Ala Lys Ala Ile Phe Ala Val Leu Thr Ser Val Leu Thr Lys Asp Asp 
    610                 615                 620                 


Trp Trp Asn Leu Leu Leu Lys Ala Ile Tyr Ser Leu Cys Asp Leu Ser 
625                 630                 635                 640 


Arg Phe Gln Glu Ala Glu Leu Leu Val Asp Ser Ser Leu Glu Tyr Tyr 
                645                 650                 655     


Ser Phe Tyr Asp Asp Arg Gln Lys Arg Lys Glu Leu Glu Tyr Phe Gly 
            660                 665                 670         


Leu Ser Ala Ala Ile Leu Asp Lys Asn Phe Arg Lys Ala Tyr Asn Tyr 
        675                 680                 685             


Ile Arg Ile Met Val Met Glu Asn Val Asn Lys Pro Gln Leu Trp Asn 
    690                 695                 700                 


Ile Phe Asn Gln Val Thr Met His Ser Gln Asp Val Arg His His Arg 
705                 710                 715                 720 


Phe Cys Leu Arg Leu Met Leu Lys Asn Pro Glu Asn His Ala Leu Cys 
                725                 730                 735     


Val Leu Asn Gly His Asn Ala Phe Val Ser Gly Ser Phe Lys His Ala 
            740                 745                 750         


Leu Gly Gln Tyr Val Gln Ala Phe Arg Thr His Pro Asp Glu Pro Leu 
        755                 760                 765             


Tyr Ser Phe Cys Ile Gly Leu Thr Phe Ile His Met Ala Ser Gln Lys 
    770                 775                 780                 


Tyr Val Leu Arg Arg His Ala Leu Ile Val Gln Gly Phe Ser Phe Leu 
785                 790                 795                 800 


Asn Arg Tyr Leu Ser Leu Arg Gly Pro Cys Gln Glu Ser Phe Tyr Asn 
                805                 810                 815     


Leu Gly Arg Gly Leu His Gln Leu Gly Leu Ile His Leu Ala Ile His 
            820                 825                 830         


Tyr Tyr Gln Lys Ala Leu Glu Leu Pro Pro Leu Val Val Glu Gly Ile 
        835                 840                 845             


Glu Leu Asp Gln Leu Asp Leu Arg Arg Asp Ile Ala Tyr Asn Leu Ser 
    850                 855                 860                 


Leu Ile Tyr Gln Ser Ser Gly Asn Thr Gly Met Ala Gln Thr Leu Leu 
865                 870                 875                 880 


Tyr Thr Tyr Cys Ser Ile 
                885     


<210>  3701
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  3701

Met Arg Gly Pro Pro Ala Trp Pro Leu Arg Leu Leu Glu Pro Pro Ser 
1               5                   10                  15      


Pro Ala Glu Pro Gly Arg Leu Leu Pro Val Ala Cys Val Trp Ala Ala 
            20                  25                  30          


Ala Ser Arg Val Pro Gly Ser Leu Ser Pro Phe Thr Gly Leu Arg Pro 
        35                  40                  45              


Ala Arg Leu Trp Gly Ala Gly Pro Ala Leu Leu Trp Gly Val Gly Ala 
    50                  55                  60                  


Ala Arg Arg Trp Arg Ser Gly Cys Arg Gly Gly Gly Pro Gly Ala Ser 
65                  70                  75                  80  


Arg Gly Val Leu Gly Leu Ala Arg Leu Leu Gly Leu Trp Ala Arg Gly 
                85                  90                  95      


Pro Gly Ser Cys Arg Cys Gly Ala Phe Ala Gly Pro Gly Ala Pro Arg 
            100                 105                 110         


Leu Pro Arg Ala Arg Phe Pro Gly Gly Pro Ala Ala Ala Ala Trp Ala 
        115                 120                 125             


Gly Asp Glu Ala Trp Arg Arg Gly Pro Ala Ala Pro Pro Gly Asp Lys 
    130                 135                 140                 


Gly Arg Leu Arg Pro Ala Ala Ala Gly Leu Pro Glu Ala Arg Lys Leu 
145                 150                 155                 160 


Leu Gly Leu Ala Tyr Pro Glu Arg Arg Arg Leu Ala Ala Ala Val Gly 
                165                 170                 175     


Phe Leu Thr Met Ser Ser Val Ile Ser Met Ser Ala Pro Phe Phe Leu 
            180                 185                 190         


Gly Lys Ile Ile Asp Val Ile Tyr Thr Asn Pro Thr Val Asp Tyr Ser 
        195                 200                 205             


Asp Asn Leu Thr Arg Leu Cys Leu Gly Leu Ser Ala Val Phe Leu Cys 
    210                 215                 220                 


Gly Ala Ala Ala Asn Ala Ile Arg Val Tyr Leu Met Gln Thr Ser Gly 
225                 230                 235                 240 


Gln Arg Ile Val Asn Arg Leu Arg Thr Ser Leu Phe Ser Ser Ile Leu 
                245                 250                 255     


Arg Gln Glu Val Ala Phe Phe Asp Lys Thr Arg Thr Gly Glu Leu Ile 
            260                 265                 270         


Asn Arg Leu Ser Ser Asp Thr Ala Leu Leu Gly Arg Ser Val Thr Glu 
        275                 280                 285             


Asn Leu Ser Asp Gly Leu Arg Ala Gly Ala Gln Ala Ser Val Gly Ile 
    290                 295                 300                 


Ser Met Met Phe Phe Val Ser Pro Asn Leu Ala Thr Phe Val Leu Ser 
305                 310                 315                 320 


Val Val Pro Pro Val Ser Ile Ile Ala Val Ile Tyr Gly Arg Tyr Leu 
                325                 330                 335     


Arg Lys Leu Thr Lys Val Thr Gln Asp Ser Leu Ala Gln Ala Thr Gln 
            340                 345                 350         


Leu Ala Glu Glu Arg Ile Gly Asn Val Arg Thr Val Arg Ala Phe Gly 
        355                 360                 365             


Lys Glu Met Thr Glu Ile Glu Lys Tyr Ala Ser Lys Val Asp His Val 
    370                 375                 380                 


Met Gln Leu Ala Arg Lys Glu Ala Phe Ala Arg Ala Gly Phe Phe Gly 
385                 390                 395                 400 


Ala Thr Gly Leu Ser Gly Asn Leu Ile Val Leu Ser Val Leu Tyr Lys 
                405                 410                 415     


Gly Gly Leu Leu Met Gly Ser Ala His Met Thr Val Gly Glu Leu Ser 
            420                 425                 430         


Ser Phe Leu Met Tyr Ala Phe Trp Val Gly Ile Ser Ile Gly Gly Leu 
        435                 440                 445             


Ser Ser Phe Tyr Ser Glu Leu Met Lys Gly Leu Gly Ala Gly Gly Arg 
    450                 455                 460                 


Leu Trp Glu Leu Leu Glu Arg Glu Pro Lys Leu Pro Phe Asn Glu Gly 
465                 470                 475                 480 


Val Ile Leu Asn Glu Lys Ser Phe Gln Gly Ala Leu Glu Phe Lys Asn 
                485                 490                 495     


Val His Phe Ala Tyr Pro Ala Arg Pro Glu Val Pro Ile Phe Gln Asp 
            500                 505                 510         


Phe Ser Leu Ser Ile Pro Ser Gly Ser Val Thr Ala Leu Val Gly Pro 
        515                 520                 525             


Ser Gly Ser Gly Lys Ser Thr Val Leu Ser Leu Leu Leu Arg Leu Tyr 
    530                 535                 540                 


Asp Pro Ala Ser Gly Thr Ile Ser Leu Asp Gly His Asp Ile Arg Gln 
545                 550                 555                 560 


Leu Asn Pro Val Trp Leu Arg Ser Lys Ile Gly Thr Val Ser Gln Glu 
                565                 570                 575     


Pro Ile Leu Phe Ser Cys Ser Ile Ala Glu Asn Ile Ala Tyr Gly Ala 
            580                 585                 590         


Asp Asp Pro Ser Ser Val Thr Ala Glu Glu Ile Gln Arg Val Ala Glu 
        595                 600                 605             


Val Ala Asn Ala Val Ala Phe Ile Arg Asn Phe Pro Gln Gly Phe Asn 
    610                 615                 620                 


Thr Val Val Gly Glu Lys Gly Val Leu Leu Ser Gly Gly Gln Lys Gln 
625                 630                 635                 640 


Arg Ile Ala Ile Ala Arg Ala Leu Leu Lys Asn Pro Lys Ile Leu Leu 
                645                 650                 655     


Leu Asp Glu Ala Thr Ser Ala Leu Asp Ala Glu Asn Glu Tyr Leu Val 
            660                 665                 670         


Gln Glu Ala Leu Asp Arg Leu Met Asp Gly Arg Thr Val Leu Val Ile 
        675                 680                 685             


Ala His Arg Leu Ser Thr Ile Lys Asn Ala Asn Met Val Ala Val Leu 
    690                 695                 700                 


Asp Gln Gly Lys Ile Thr Glu Tyr Gly Lys His Glu Glu Leu Leu Ser 
705                 710                 715                 720 


Lys Pro Asn Gly Ile Tyr Arg Lys Leu Met Asn Lys Gln Ser Phe Ile 
                725                 730                 735     


Ser Ala 
        


<210>  3702
<211>  5430
<212>  PRT
<213>  Homo sapiens

<400>  3702

Met Ser Ser Ser Asp Glu Glu Thr Leu Ser Glu Arg Ser Cys Arg Ser 
1               5                   10                  15      


Glu Arg Ser Cys Arg Ser Glu Arg Ser Tyr Arg Ser Glu Arg Ser Gly 
            20                  25                  30          


Ser Leu Ser Pro Cys Pro Pro Gly Asp Thr Leu Pro Trp Asn Leu Pro 
        35                  40                  45              


Leu His Glu Gln Lys Lys Arg Lys Ser Gln Asp Ser Val Leu Asp Pro 
    50                  55                  60                  


Ala Glu Arg Ala Val Val Arg Val Ala Asp Glu Arg Asp Arg Val Gln 
65                  70                  75                  80  


Lys Lys Thr Phe Thr Lys Trp Val Asn Lys His Leu Met Lys Val Arg 
                85                  90                  95      


Lys His Ile Asn Asp Leu Tyr Glu Asp Leu Arg Asp Gly His Asn Leu 
            100                 105                 110         


Ile Ser Leu Leu Glu Val Leu Ser Gly Ile Lys Leu Pro Arg Glu Lys 
        115                 120                 125             


Gly Arg Met Arg Phe His Arg Leu Gln Asn Val Gln Ile Ala Leu Asp 
    130                 135                 140                 


Phe Leu Lys Gln Arg Gln Val Lys Leu Val Asn Ile Arg Asn Asp Asp 
145                 150                 155                 160 


Ile Thr Asp Gly Asn Pro Lys Leu Thr Leu Gly Leu Ile Trp Thr Ile 
                165                 170                 175     


Ile Leu His Phe Gln Ile Ser Asp Ile Tyr Ile Ser Gly Glu Ser Gly 
            180                 185                 190         


Asp Met Ser Ala Lys Glu Lys Leu Leu Leu Trp Thr Gln Lys Val Thr 
        195                 200                 205             


Ala Gly Tyr Thr Gly Ile Lys Cys Thr Asn Phe Ser Ser Cys Trp Ser 
    210                 215                 220                 


Asp Gly Lys Met Phe Asn Ala Leu Ile His Arg Tyr Arg Pro Asp Leu 
225                 230                 235                 240 


Val Asp Met Glu Arg Val Gln Ile Gln Ser Asn Arg Glu Asn Leu Glu 
                245                 250                 255     


Gln Ala Phe Glu Val Ala Glu Arg Leu Gly Val Thr Arg Leu Leu Asp 
            260                 265                 270         


Ala Glu Asp Val Asp Val Pro Ser Pro Asp Glu Lys Ser Val Ile Thr 
        275                 280                 285             


Tyr Val Ser Ser Ile Tyr Asp Ala Phe Pro Lys Val Pro Glu Gly Gly 
    290                 295                 300                 


Glu Gly Ile Ser Ala Thr Glu Val Asp Ser Arg Trp Gln Glu Tyr Gln 
305                 310                 315                 320 


Ser Arg Val Asp Ser Leu Ile Pro Trp Ile Lys Gln His Thr Ile Leu 
                325                 330                 335     


Met Ser Asp Lys Thr Phe Pro Gln Asn Pro Val Glu Leu Lys Ala Leu 
            340                 345                 350         


Tyr Asn Gln Tyr Ile His Phe Lys Glu Thr Glu Ile Leu Ala Lys Glu 
        355                 360                 365             


Arg Glu Lys Gly Arg Ile Glu Glu Leu Tyr Lys Leu Leu Glu Val Trp 
    370                 375                 380                 


Ile Glu Phe Gly Arg Ile Lys Leu Pro Gln Gly Tyr His Pro Asn Asp 
385                 390                 395                 400 


Val Glu Glu Glu Trp Gly Lys Leu Ile Ile Glu Met Leu Glu Arg Glu 
                405                 410                 415     


Lys Ser Leu Arg Pro Ala Val Glu Arg Leu Glu Leu Leu Leu Gln Ile 
            420                 425                 430         


Ala Asn Lys Ile Gln Asn Gly Ala Leu Asn Cys Glu Glu Lys Leu Thr 
        435                 440                 445             


Leu Ala Lys Asn Thr Leu Gln Ala Asp Ala Ala His Leu Glu Ser Gly 
    450                 455                 460                 


Gln Pro Val Gln Cys Glu Ser Asp Val Ile Met Tyr Ile Gln Glu Cys 
465                 470                 475                 480 


Glu Gly Leu Ile Arg Gln Leu Gln Val Asp Leu Gln Ile Leu Arg Asp 
                485                 490                 495     


Glu Asn Tyr Tyr Gln Leu Glu Glu Leu Ala Phe Arg Val Met Arg Leu 
            500                 505                 510         


Gln Asp Glu Leu Val Thr Leu Arg Leu Glu Cys Thr Asn Leu Tyr Arg 
        515                 520                 525             


Lys Gly His Phe Thr Ser Leu Glu Leu Val Pro Pro Ser Thr Leu Thr 
    530                 535                 540                 


Thr Thr His Leu Lys Ala Glu Pro Leu Thr Lys Ala Thr His Ser Ser 
545                 550                 555                 560 


Ser Thr Ser Trp Phe Arg Lys Pro Met Thr Arg Ala Glu Leu Val Ala 
                565                 570                 575     


Ile Ser Ser Ser Glu Asp Glu Gly Asn Leu Arg Phe Val Tyr Glu Leu 
            580                 585                 590         


Leu Ser Trp Val Glu Glu Met Gln Met Lys Leu Glu Arg Ala Glu Trp 
        595                 600                 605             


Gly Asn Asp Leu Pro Ser Val Glu Leu Gln Leu Glu Thr Gln Gln His 
    610                 615                 620                 


Ile His Thr Ser Val Glu Glu Leu Gly Ser Ser Val Lys Glu Ala Arg 
625                 630                 635                 640 


Leu Tyr Glu Gly Lys Met Ser Gln Asn Phe His Thr Ser Tyr Ala Glu 
                645                 650                 655     


Thr Leu Gly Lys Leu Glu Thr Gln Tyr Cys Lys Leu Lys Glu Thr Ser 
            660                 665                 670         


Ser Phe Arg Met Arg His Leu Gln Ser Leu His Lys Phe Val Ser Arg 
        675                 680                 685             


Ala Thr Ala Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu Leu 
    690                 695                 700                 


Ala Tyr Asp Trp Ser Asp Asn Asn Ser Asn Ile Ser Ala Lys Arg Asn 
705                 710                 715                 720 


Tyr Phe Ser Glu Leu Thr Met Glu Leu Glu Glu Lys Gln Asp Val Phe 
                725                 730                 735     


Arg Ser Leu Gln Asp Thr Ala Glu Leu Leu Ser Leu Glu Asn His Pro 
            740                 745                 750         


Ala Lys Gln Thr Val Glu Ala Tyr Ser Ala Ala Val Gln Ser Gln Leu 
        755                 760                 765             


Gln Trp Met Lys Gln Leu Cys Leu Cys Val Glu Gln His Val Lys Glu 
    770                 775                 780                 


Asn Thr Ala Tyr Phe Gln Phe Phe Ser Asp Ala Arg Glu Leu Glu Ser 
785                 790                 795                 800 


Phe Leu Arg Asn Leu Gln Asp Ser Ile Lys Arg Lys Tyr Ser Cys Asp 
                805                 810                 815     


His Asn Thr Ser Leu Ser Arg Leu Glu Asp Leu Leu Gln Asp Ser Met 
            820                 825                 830         


Asp Glu Lys Glu Gln Leu Ile Gln Ser Lys Ser Ser Val Ala Ser Leu 
        835                 840                 845             


Val Gly Arg Ser Lys Thr Ile Val Gln Leu Lys Pro Arg Ser Pro Asp 
    850                 855                 860                 


His Val Leu Lys Asn Thr Ile Ser Val Lys Ala Val Cys Asp Tyr Arg 
865                 870                 875                 880 


Gln Ile Glu Ile Thr Ile Cys Lys Asn Asp Glu Cys Val Leu Glu Asp 
                885                 890                 895     


Asn Ser Gln Arg Thr Lys Trp Lys Val Ile Ser Pro Thr Gly Asn Glu 
            900                 905                 910         


Ala Met Val Pro Ser Val Cys Phe Leu Ile Pro Pro Pro Asn Lys Asp 
        915                 920                 925             


Ala Ile Glu Met Ala Ser Arg Val Glu Gln Ser Tyr Gln Lys Val Met 
    930                 935                 940                 


Ala Leu Trp His Gln Leu His Val Asn Thr Lys Ser Leu Ile Ser Trp 
945                 950                 955                 960 


Asn Tyr Leu Arg Lys Asp Leu Asp Leu Val Gln Thr Trp Asn Leu Glu 
                965                 970                 975     


Lys Leu Arg Ser Ser Ala Pro Gly Glu Cys His Gln Ile Met Lys Asn 
            980                 985                 990         


Leu Gln Ala His Tyr Glu Asp Phe  Leu Gln Asp Ser Arg  Asp Ser Val 
        995                 1000                 1005             


Leu Phe  Ser Val Ala Asp Arg  Leu Arg Leu Glu Glu  Glu Val Glu 
    1010                 1015                 1020             


Ala Cys  Lys Ala Arg Phe Gln  His Leu Met Lys Ser  Met Glu Asn 
    1025                 1030                 1035             


Glu Asp  Lys Glu Glu Thr Val  Ala Lys Met Tyr Ile  Ser Glu Leu 
    1040                 1045                 1050             


Lys Asn  Ile Arg Leu Arg Leu  Glu Glu Tyr Glu Gln  Arg Val Val 
    1055                 1060                 1065             


Lys Arg  Ile Gln Ser Leu Ala  Ser Ser Arg Thr Asp  Arg Asp Ala 
    1070                 1075                 1080             


Trp Gln  Asp Asn Ala Leu Arg  Ile Ala Glu Gln Glu  His Thr Gln 
    1085                 1090                 1095             


Glu Asp  Leu Gln Gln Leu Arg  Ser Asp Leu Asp Ala  Val Ser Met 
    1100                 1105                 1110             


Lys Cys  Asp Ser Phe Leu His  Gln Ser Pro Ser Ser  Ser Ser Val 
    1115                 1120                 1125             


Pro Thr  Leu Arg Ser Glu Leu  Asn Leu Leu Val Glu  Lys Met Asp 
    1130                 1135                 1140             


His Val  Tyr Gly Leu Ser Thr  Val Tyr Leu Asn Lys  Leu Lys Thr 
    1145                 1150                 1155             


Val Asp  Val Ile Val Arg Ser  Ile Gln Asp Ala Glu  Leu Leu Val 
    1160                 1165                 1170             


Lys Gly  Tyr Glu Ile Lys Leu  Ser Gln Glu Glu Val  Val Leu Ala 
    1175                 1180                 1185             


Asp Leu  Ser Ala Leu Glu Ala  His Trp Ser Thr Leu  Arg His Trp 
    1190                 1195                 1200             


Leu Ser  Asp Val Lys Asp Lys  Asn Ser Val Phe Ser  Val Leu Asp 
    1205                 1210                 1215             


Glu Glu  Ile Ala Lys Ala Lys  Val Val Ala Glu Gln  Met Ser Arg 
    1220                 1225                 1230             


Leu Thr  Pro Glu Arg Asn Leu  Asp Leu Glu Arg Tyr  Gln Glu Lys 
    1235                 1240                 1245             


Gly Ser  Gln Leu Gln Glu Arg  Trp His Arg Val Ile  Ala Gln Leu 
    1250                 1255                 1260             


Glu Ile  Arg Gln Ser Glu Leu  Glu Ser Ile Gln Glu  Val Leu Gly 
    1265                 1270                 1275             


Asp Tyr  Arg Ala Cys His Gly  Thr Leu Ile Lys Trp  Ile Glu Glu 
    1280                 1285                 1290             


Thr Thr  Ala Gln Gln Glu Met  Met Lys Pro Gly Gln  Ala Glu Asp 
    1295                 1300                 1305             


Ser Arg  Val Leu Ser Glu Gln  Leu Ser Gln Gln Thr  Ala Leu Phe 
    1310                 1315                 1320             


Ala Glu  Ile Glu Arg Asn Gln  Thr Lys Leu Asp Gln  Cys Gln Lys 
    1325                 1330                 1335             


Phe Ser  Gln Gln Tyr Ser Thr  Ile Val Lys Asp Tyr  Glu Leu Gln 
    1340                 1345                 1350             


Leu Met  Thr Tyr Lys Ala Phe  Val Glu Ser Gln Gln  Lys Ser Pro 
    1355                 1360                 1365             


Gly Lys  Arg Arg Arg Met Leu  Ser Ser Ser Asp Ala  Ile Thr Gln 
    1370                 1375                 1380             


Glu Phe  Met Asp Leu Arg Thr  Arg Tyr Thr Ala Leu  Val Thr Leu 
    1385                 1390                 1395             


Thr Thr  Gln His Val Lys Tyr  Ile Ser Asp Ala Leu  Arg Arg Leu 
    1400                 1405                 1410             


Glu Glu  Glu Glu Lys Val Val  Glu Glu Glu Lys Gln  Glu His Val 
    1415                 1420                 1425             


Glu Lys  Val Lys Glu Leu Leu  Gly Trp Val Ser Thr  Leu Ala Arg 
    1430                 1435                 1440             


Asn Thr  Gln Gly Lys Ala Thr  Ser Ser Glu Thr Lys  Glu Ser Thr 
    1445                 1450                 1455             


Asp Ile  Glu Lys Ala Ile Leu  Glu Gln Gln Val Leu  Ser Glu Glu 
    1460                 1465                 1470             


Leu Thr  Thr Lys Lys Glu Gln  Val Ser Glu Ala Ile  Lys Thr Ser 
    1475                 1480                 1485             


Gln Ile  Phe Leu Ala Lys His  Gly His Lys Leu Ser  Glu Lys Glu 
    1490                 1495                 1500             


Lys Lys  Gln Ile Ser Glu Gln  Leu Asn Ala Leu Asn  Lys Ala Tyr 
    1505                 1510                 1515             


His Asp  Leu Cys Asp Gly Ser  Ala Asn Gln Leu Gln  Gln Leu Gln 
    1520                 1525                 1530             


Ser Gln  Leu Ala His Gln Thr  Glu Gln Lys Thr Leu  Gln Lys Gln 
    1535                 1540                 1545             


Gln Asn  Thr Cys His Gln Gln  Leu Glu Asp Leu Cys  Ser Trp Val 
    1550                 1555                 1560             


Gly Gln  Ala Glu Arg Ala Leu  Ala Gly His Gln Gly  Arg Thr Thr 
    1565                 1570                 1575             


Gln Gln  Asp Leu Ser Ala Leu  Gln Lys Asn Gln Ser  Asp Leu Lys 
    1580                 1585                 1590             


Asp Leu  Gln Asp Asp Ile Gln  Asn Arg Ala Thr Ser  Phe Ala Thr 
    1595                 1600                 1605             


Val Val  Lys Asp Ile Glu Gly  Phe Met Glu Glu Asn  Gln Thr Lys 
    1610                 1615                 1620             


Leu Ser  Pro Arg Glu Leu Thr  Ala Leu Arg Glu Lys  Leu His Gln 
    1625                 1630                 1635             


Ala Lys  Glu Gln Tyr Glu Ala  Leu Gln Glu Glu Thr  Arg Val Ala 
    1640                 1645                 1650             


Gln Lys  Glu Leu Glu Glu Ala  Val Thr Ser Ala Leu  Gln Gln Glu 
    1655                 1660                 1665             


Thr Glu  Lys Ser Lys Ala Ala  Lys Glu Leu Ala Glu  Asn Lys Lys 
    1670                 1675                 1680             


Lys Ile  Asp Ala Leu Leu Asp  Trp Val Thr Ser Val  Gly Ser Ser 
    1685                 1690                 1695             


Gly Gly  Gln Leu Leu Thr Asn  Leu Pro Gly Met Glu  Gln Leu Ser 
    1700                 1705                 1710             


Gly Ala  Ser Leu Glu Lys Gly  Ala Leu Asp Thr Thr  Asp Gly Tyr 
    1715                 1720                 1725             


Met Gly  Val Asn Gln Ala Pro  Glu Lys Leu Asp Lys  Gln Cys Glu 
    1730                 1735                 1740             


Met Met  Lys Ala Arg His Gln  Glu Leu Leu Ser Gln  Gln Gln Asn 
    1745                 1750                 1755             


Phe Ile  Leu Ala Thr Gln Ser  Ala Gln Ala Phe Leu  Asp Gln His 
    1760                 1765                 1770             


Gly His  Asn Leu Thr Pro Glu  Glu Gln Gln Met Leu  Gln Gln Lys 
    1775                 1780                 1785             


Leu Gly  Glu Leu Lys Glu Gln  Tyr Ser Thr Ser Leu  Ala Gln Ser 
    1790                 1795                 1800             


Glu Ala  Glu Leu Lys Gln Val  Gln Thr Leu Gln Asp  Glu Leu Gln 
    1805                 1810                 1815             


Lys Phe  Leu Gln Asp His Lys  Glu Phe Glu Ser Trp  Leu Glu Arg 
    1820                 1825                 1830             


Ser Glu  Lys Glu Leu Glu Asn  Met His Lys Gly Gly  Ser Ser Pro 
    1835                 1840                 1845             


Glu Thr  Leu Pro Ser Leu Leu  Lys Arg Gln Gly Ser  Phe Ser Glu 
    1850                 1855                 1860             


Asp Val  Ile Ser His Lys Gly  Asp Leu Arg Phe Val  Thr Ile Ser 
    1865                 1870                 1875             


Gly Gln  Lys Val Leu Asp Met  Glu Asn Ser Phe Lys  Glu Gly Lys 
    1880                 1885                 1890             


Glu Pro  Ser Glu Ile Gly Asn  Leu Val Lys Asp Lys  Leu Lys Asp 
    1895                 1900                 1905             


Ala Thr  Glu Arg Tyr Thr Ala  Leu His Ser Lys Cys  Thr Arg Leu 
    1910                 1915                 1920             


Gly Ser  His Leu Asn Met Leu  Leu Gly Gln Tyr His  Gln Phe Gln 
    1925                 1930                 1935             


Asn Ser  Ala Asp Ser Leu Gln  Ala Trp Met Gln Ala  Cys Glu Ala 
    1940                 1945                 1950             


Asn Val  Glu Lys Leu Leu Ser  Asp Thr Val Ala Ser  Asp Pro Gly 
    1955                 1960                 1965             


Val Leu  Gln Glu Gln Leu Ala  Thr Thr Lys Gln Leu  Gln Glu Glu 
    1970                 1975                 1980             


Leu Ala  Glu His Gln Val Pro  Val Glu Lys Leu Gln  Lys Val Ala 
    1985                 1990                 1995             


Arg Asp  Ile Met Glu Ile Glu  Gly Glu Pro Ala Pro  Asp His Arg 
    2000                 2005                 2010             


His Val  Gln Glu Thr Thr Asp  Ser Ile Leu Ser His  Phe Gln Ser 
    2015                 2020                 2025             


Leu Ser  Tyr Ser Leu Ala Glu  Arg Ser Ser Leu Leu  Gln Lys Ala 
    2030                 2035                 2040             


Ile Ala  Gln Ser Gln Ser Val  Gln Glu Ser Leu Glu  Ser Leu Leu 
    2045                 2050                 2055             


Gln Ser  Ile Gly Glu Val Glu  Gln Asn Leu Glu Gly  Lys Gln Val 
    2060                 2065                 2070             


Ser Ser  Leu Ser Ser Gly Val  Ile Gln Glu Ala Leu  Ala Thr Asn 
    2075                 2080                 2085             


Met Lys  Leu Lys Gln Asp Ile  Ala Arg Gln Lys Ser  Ser Leu Glu 
    2090                 2095                 2100             


Ala Thr  Arg Glu Met Val Thr  Arg Phe Met Glu Thr  Ala Asp Ser 
    2105                 2110                 2115             


Thr Thr  Ala Ala Val Leu Gln  Gly Lys Leu Ala Glu  Val Ser Gln 
    2120                 2125                 2130             


Arg Phe  Glu Gln Leu Cys Leu  Gln Gln Gln Glu Lys  Glu Ser Ser 
    2135                 2140                 2145             


Leu Lys  Lys Leu Leu Pro Gln  Ala Glu Met Phe Glu  His Leu Ser 
    2150                 2155                 2160             


Gly Lys  Leu Gln Gln Phe Met  Glu Asn Lys Ser Arg  Met Leu Ala 
    2165                 2170                 2175             


Ser Gly  Asn Gln Pro Asp Gln  Asp Ile Thr His Phe  Phe Gln Gln 
    2180                 2185                 2190             


Ile Gln  Glu Leu Asn Leu Glu  Met Glu Asp Gln Gln  Glu Asn Leu 
    2195                 2200                 2205             


Asp Thr  Leu Glu His Leu Val  Thr Glu Leu Ser Ser  Cys Gly Phe 
    2210                 2215                 2220             


Ala Leu  Asp Leu Cys Gln His  Gln Asp Arg Val Gln  Asn Leu Arg 
    2225                 2230                 2235             


Lys Asp  Phe Thr Glu Leu Gln  Lys Thr Val Lys Glu  Arg Glu Lys 
    2240                 2245                 2250             


Asp Ala  Ser Ser Cys Gln Glu  Gln Leu Asp Glu Phe  Arg Lys Leu 
    2255                 2260                 2265             


Val Arg  Thr Phe Gln Lys Trp  Leu Lys Glu Thr Glu  Gly Ser Ile 
    2270                 2275                 2280             


Pro Pro  Thr Glu Thr Ser Met  Ser Ala Lys Glu Leu  Glu Lys Gln 
    2285                 2290                 2295             


Ile Glu  His Leu Lys Ser Leu  Leu Asp Asp Trp Ala  Ser Lys Gly 
    2300                 2305                 2310             


Thr Leu  Val Glu Glu Ile Asn  Cys Lys Gly Thr Ser  Leu Glu Asn 
    2315                 2320                 2325             


Leu Ile  Met Glu Ile Thr Ala  Pro Asp Ser Gln Gly  Lys Thr Gly 
    2330                 2335                 2340             


Ser Ile  Leu Pro Ser Val Gly  Ser Ser Val Gly Ser  Val Asn Gly 
    2345                 2350                 2355             


Tyr His  Thr Cys Lys Asp Leu  Thr Glu Ile Gln Cys  Asp Met Ser 
    2360                 2365                 2370             


Asp Val  Asn Leu Lys Tyr Glu  Lys Leu Gly Gly Val  Leu His Glu 
    2375                 2380                 2385             


Arg Gln  Glu Ser Leu Gln Ala  Ile Leu Asn Arg Met  Glu Glu Val 
    2390                 2395                 2400             


His Lys  Glu Ala Asn Ser Val  Leu Gln Trp Leu Glu  Ser Lys Glu 
    2405                 2410                 2415             


Glu Val  Leu Lys Ser Met Asp  Ala Met Ser Ser Pro  Thr Lys Thr 
    2420                 2425                 2430             


Glu Thr  Val Lys Ala Gln Ala  Glu Ser Asn Lys Ala  Phe Leu Ala 
    2435                 2440                 2445             


Glu Leu  Glu Gln Asn Ser Pro  Lys Ile Gln Lys Val  Lys Glu Ala 
    2450                 2455                 2460             


Leu Ala  Gly Leu Leu Val Thr  Tyr Pro Asn Ser Gln  Glu Ala Glu 
    2465                 2470                 2475             


Asn Trp  Lys Lys Ile Gln Glu  Glu Leu Asn Ser Arg  Trp Glu Arg 
    2480                 2485                 2490             


Ala Thr  Glu Val Thr Val Ala  Arg Gln Arg Gln Leu  Glu Glu Ser 
    2495                 2500                 2505             


Ala Ser  His Leu Ala Cys Phe  Gln Ala Ala Glu Ser  Gln Leu Arg 
    2510                 2515                 2520             


Pro Trp  Leu Met Glu Lys Glu  Leu Met Met Gly Val  Leu Gly Pro 
    2525                 2530                 2535             


Leu Ser  Ile Asp Pro Asn Met  Leu Asn Ala Gln Lys  Gln Gln Val 
    2540                 2545                 2550             


Gln Phe  Met Leu Lys Glu Phe  Glu Ala Arg Arg Gln  Gln His Glu 
    2555                 2560                 2565             


Gln Leu  Asn Glu Ala Ala Gln  Gly Ile Leu Thr Gly  Pro Gly Asp 
    2570                 2575                 2580             


Val Ser  Leu Ser Thr Ser Gln  Val Gln Lys Glu Leu  Gln Ser Ile 
    2585                 2590                 2595             


Asn Gln  Lys Trp Val Glu Leu  Thr Asp Lys Leu Asn  Ser Arg Ser 
    2600                 2605                 2610             


Ser Gln  Ile Asp Gln Ala Ile  Val Lys Ser Thr Gln  Tyr Gln Glu 
    2615                 2620                 2625             


Leu Leu  Gln Asp Leu Ser Glu  Lys Val Arg Ala Val  Gly Gln Arg 
    2630                 2635                 2640             


Leu Ser  Val Gln Ser Ala Ile  Ser Thr Gln Pro Glu  Ala Val Lys 
    2645                 2650                 2655             


Gln Gln  Leu Glu Glu Thr Ser  Glu Ile Arg Ser Asp  Leu Glu Gln 
    2660                 2665                 2670             


Leu Asp  His Glu Val Lys Glu  Ala Gln Thr Leu Cys  Asp Glu Leu 
    2675                 2680                 2685             


Ser Val  Leu Ile Gly Glu Gln  Tyr Leu Lys Asp Glu  Leu Lys Lys 
    2690                 2695                 2700             


Arg Leu  Glu Thr Val Ala Leu  Pro Leu Gln Gly Leu  Glu Asp Leu 
    2705                 2710                 2715             


Ala Ala  Asp Arg Ile Asn Arg  Leu Gln Ala Ala Leu  Ala Ser Thr 
    2720                 2725                 2730             


Gln Gln  Phe Gln Gln Met Phe  Asp Glu Leu Arg Thr  Trp Leu Asp 
    2735                 2740                 2745             


Asp Lys  Gln Ser Gln Gln Ala  Lys Asn Cys Pro Ile  Ser Ala Lys 
    2750                 2755                 2760             


Leu Glu  Arg Leu Gln Ser Gln  Leu Gln Glu Asn Glu  Glu Phe Gln 
    2765                 2770                 2775             


Lys Ser  Leu Asn Gln His Ser  Gly Ser Tyr Glu Val  Ile Val Ala 
    2780                 2785                 2790             


Glu Gly  Glu Ser Leu Leu Leu  Ser Val Pro Pro Gly  Glu Glu Lys 
    2795                 2800                 2805             


Arg Thr  Leu Gln Asn Gln Leu  Val Glu Leu Lys Asn  His Trp Glu 
    2810                 2815                 2820             


Glu Leu  Ser Lys Lys Thr Ala  Asp Arg Gln Ser Arg  Leu Lys Asp 
    2825                 2830                 2835             


Cys Met  Gln Lys Ala Gln Lys  Tyr Gln Trp His Val  Glu Asp Leu 
    2840                 2845                 2850             


Val Pro  Trp Ile Glu Asp Cys  Lys Ala Lys Met Ser  Glu Leu Arg 
    2855                 2860                 2865             


Val Thr  Leu Asp Pro Val Gln  Leu Glu Ser Ser Leu  Leu Arg Ser 
    2870                 2875                 2880             


Lys Ala  Met Leu Asn Glu Val  Glu Lys Arg Arg Ser  Leu Leu Glu 
    2885                 2890                 2895             


Ile Leu  Asn Ser Ala Ala Asp  Ile Leu Ile Asn Ser  Ser Glu Ala 
    2900                 2905                 2910             


Asp Glu  Asp Gly Ile Arg Asp  Glu Lys Ala Gly Ile  Asn Gln Asn 
    2915                 2920                 2925             


Met Asp  Ala Val Thr Glu Glu  Leu Gln Ala Lys Thr  Gly Ser Leu 
    2930                 2935                 2940             


Glu Glu  Met Thr Gln Arg Leu  Arg Glu Phe Gln Glu  Ser Phe Lys 
    2945                 2950                 2955             


Asn Ile  Glu Lys Lys Val Glu  Gly Ala Lys His Gln  Leu Glu Ile 
    2960                 2965                 2970             


Phe Asp  Ala Leu Gly Ser Gln  Ala Cys Ser Asn Lys  Asn Leu Glu 
    2975                 2980                 2985             


Lys Leu  Arg Ala Gln Gln Glu  Val Leu Gln Ala Leu  Glu Pro Gln 
    2990                 2995                 3000             


Val Asp  Tyr Leu Arg Asn Phe  Thr Gln Gly Leu Val  Glu Asp Ala 
    3005                 3010                 3015             


Pro Asp  Gly Ser Asp Ala Ser  Gln Leu Leu His Gln  Ala Glu Val 
    3020                 3025                 3030             


Ala Gln  Gln Glu Phe Leu Glu  Val Lys Gln Arg Val  Asn Ser Gly 
    3035                 3040                 3045             


Cys Val  Met Met Glu Asn Lys  Leu Glu Gly Ile Gly  Gln Phe His 
    3050                 3055                 3060             


Cys Arg  Val Arg Glu Met Phe  Ser Gln Leu Ala Asp  Leu Asp Asp 
    3065                 3070                 3075             


Glu Leu  Asp Gly Met Gly Ala  Ile Gly Arg Asp Thr  Asp Ser Leu 
    3080                 3085                 3090             


Gln Ser  Gln Ile Glu Asp Val  Arg Leu Phe Leu Asn  Lys Ile His 
    3095                 3100                 3105             


Val Leu  Lys Leu Asp Ile Glu  Ala Ser Glu Ala Glu  Cys Arg His 
    3110                 3115                 3120             


Met Leu  Glu Glu Glu Gly Thr  Leu Asp Leu Leu Gly  Leu Lys Arg 
    3125                 3130                 3135             


Glu Leu  Glu Ala Leu Asn Lys  Gln Cys Gly Lys Leu  Thr Glu Arg 
    3140                 3145                 3150             


Gly Lys  Ala Arg Gln Glu Gln  Leu Glu Leu Thr Leu  Gly Arg Val 
    3155                 3160                 3165             


Glu Asp  Phe Tyr Arg Lys Leu  Lys Gly Leu Asn Asp  Ala Thr Thr 
    3170                 3175                 3180             


Ala Ala  Glu Glu Ala Glu Ala  Leu Gln Trp Val Val  Gly Thr Glu 
    3185                 3190                 3195             


Val Glu  Ile Ile Asn Gln Gln  Leu Ala Asp Phe Lys  Met Phe Gln 
    3200                 3205                 3210             


Lys Glu  Gln Val Asp Pro Leu  Gln Met Lys Leu Gln  Gln Val Asn 
    3215                 3220                 3225             


Gly Leu  Gly Gln Gly Leu Ile  Gln Ser Ala Gly Lys  Asp Cys Asp 
    3230                 3235                 3240             


Val Gln  Gly Leu Glu His Asp  Met Glu Glu Ile Asn  Ala Arg Trp 
    3245                 3250                 3255             


Asn Thr  Leu Asn Lys Lys Val  Ala Gln Arg Ile Ala  Gln Leu Gln 
    3260                 3265                 3270             


Glu Ala  Leu Leu His Cys Gly  Lys Phe Gln Asp Ala  Leu Glu Pro 
    3275                 3280                 3285             


Leu Leu  Ser Trp Leu Ala Asp  Thr Glu Glu Leu Ile  Ala Asn Gln 
    3290                 3295                 3300             


Lys Pro  Pro Ser Ala Glu Tyr  Lys Val Val Lys Ala  Gln Ile Gln 
    3305                 3310                 3315             


Glu Gln  Lys Leu Leu Gln Arg  Leu Leu Asp Asp Arg  Lys Ala Thr 
    3320                 3325                 3330             


Val Asp  Met Leu Gln Ala Glu  Gly Gly Arg Ile Ala  Gln Ser Ala 
    3335                 3340                 3345             


Glu Leu  Ala Asp Arg Glu Lys  Ile Thr Gly Gln Leu  Glu Ser Leu 
    3350                 3355                 3360             


Glu Ser  Arg Trp Thr Glu Leu  Leu Ser Lys Ala Ala  Ala Arg Gln 
    3365                 3370                 3375             


Lys Gln  Leu Glu Asp Ile Leu  Val Leu Ala Lys Gln  Phe His Glu 
    3380                 3385                 3390             


Thr Ala  Glu Pro Ile Ser Asp  Phe Leu Ser Val Thr  Glu Lys Lys 
    3395                 3400                 3405             


Leu Ala  Asn Ser Glu Pro Val  Gly Thr Gln Thr Ala  Lys Ile Gln 
    3410                 3415                 3420             


Gln Gln  Ile Ile Arg His Lys  Ala Leu Glu Glu Asp  Ile Glu Asn 
    3425                 3430                 3435             


His Ala  Thr Asp Val His Gln  Ala Val Lys Ile Gly  Gln Ser Leu 
    3440                 3445                 3450             


Ser Ser  Leu Thr Ser Pro Ala  Glu Gln Gly Val Leu  Ser Glu Lys 
    3455                 3460                 3465             


Ile Asp  Ser Leu Gln Ala Arg  Tyr Ser Glu Ile Gln  Asp Arg Cys 
    3470                 3475                 3480             


Cys Arg  Lys Ala Ala Leu Leu  Asp Gln Ala Leu Ser  Asn Ala Arg 
    3485                 3490                 3495             


Leu Phe  Gly Glu Asp Glu Val  Glu Val Leu Asn Trp  Leu Ala Glu 
    3500                 3505                 3510             


Val Glu  Asp Lys Leu Ser Ser  Val Phe Val Lys Asp  Phe Lys Gln 
    3515                 3520                 3525             


Asp Val  Leu His Arg Gln His  Ala Asp His Leu Ala  Leu Asn Glu 
    3530                 3535                 3540             


Glu Ile  Val Asn Arg Lys Lys  Asn Val Asp Gln Ala  Ile Lys Asn 
    3545                 3550                 3555             


Gly Gln  Ala Leu Leu Lys Gln  Thr Thr Gly Glu Glu  Val Leu Leu 
    3560                 3565                 3570             


Ile Gln  Glu Lys Leu Asp Gly  Ile Lys Thr Arg Tyr  Ala Asp Ile 
    3575                 3580                 3585             


Thr Val  Thr Ser Ser Lys Ala  Leu Arg Thr Leu Glu  Gln Ala Arg 
    3590                 3595                 3600             


Gln Leu  Ala Thr Lys Phe Gln  Ser Thr Tyr Glu Glu  Leu Thr Gly 
    3605                 3610                 3615             


Trp Leu  Arg Glu Val Glu Glu  Glu Leu Ala Thr Ser  Gly Gly Gln 
    3620                 3625                 3630             


Ser Pro  Thr Gly Glu Gln Ile  Pro Gln Phe Gln Gln  Arg Gln Lys 
    3635                 3640                 3645             


Glu Leu  Lys Lys Glu Val Met  Glu His Arg Leu Val  Leu Asp Thr 
    3650                 3655                 3660             


Val Asn  Glu Val Ser Arg Ala  Leu Leu Glu Leu Val  Pro Trp Arg 
    3665                 3670                 3675             


Ala Arg  Glu Gly Leu Asp Lys  Leu Val Ser Asp Ala  Asn Glu Gln 
    3680                 3685                 3690             


Tyr Lys  Leu Val Ser Asp Thr  Ile Gly Gln Arg Val  Asp Glu Ile 
    3695                 3700                 3705             


Asp Ala  Ala Ile Gln Arg Ser  Gln Gln Tyr Glu Gln  Ala Ala Asp 
    3710                 3715                 3720             


Ala Glu  Leu Ala Trp Val Ala  Glu Thr Lys Arg Lys  Leu Met Ala 
    3725                 3730                 3735             


Leu Gly  Pro Ile Arg Leu Glu  Gln Asp Gln Thr Thr  Ala Gln Leu 
    3740                 3745                 3750             


Gln Val  Gln Lys Ala Phe Ser  Ile Asp Ile Ile Arg  His Lys Asp 
    3755                 3760                 3765             


Ser Met  Asp Glu Leu Phe Ser  His Arg Ser Glu Ile  Phe Gly Thr 
    3770                 3775                 3780             


Cys Gly  Glu Glu Gln Lys Thr  Val Leu Gln Glu Lys  Thr Glu Ser 
    3785                 3790                 3795             


Leu Ile  Gln Gln Tyr Glu Ala  Ile Ser Leu Leu Asn  Ser Glu Arg 
    3800                 3805                 3810             


Tyr Ala  Arg Leu Glu Arg Ala  Gln Val Leu Val Asn  Gln Phe Trp 
    3815                 3820                 3825             


Glu Thr  Tyr Glu Glu Leu Ser  Pro Trp Ile Glu Glu  Thr Arg Ala 
    3830                 3835                 3840             


Leu Ile  Ala Gln Leu Pro Ser  Pro Ala Ile Asp His  Glu Gln Leu 
    3845                 3850                 3855             


Arg Gln  Gln Gln Glu Glu Met  Arg Gln Leu Arg Glu  Ser Ile Ala 
    3860                 3865                 3870             


Glu His  Lys Pro His Ile Asp  Lys Leu Leu Lys Ile  Gly Pro Gln 
    3875                 3880                 3885             


Leu Lys  Glu Leu Asn Pro Glu  Glu Gly Glu Met Val  Glu Glu Lys 
    3890                 3895                 3900             


Tyr Gln  Lys Ala Glu Asn Met  Tyr Ala Gln Ile Lys  Glu Glu Val 
    3905                 3910                 3915             


Arg Gln  Arg Ala Leu Ala Leu  Asp Glu Ala Val Ser  Gln Ser Thr 
    3920                 3925                 3930             


Gln Ile  Thr Glu Phe His Asp  Lys Ile Glu Pro Met  Leu Glu Thr 
    3935                 3940                 3945             


Leu Glu  Asn Leu Ser Ser Arg  Leu Arg Met Pro Pro  Leu Ile Pro 
    3950                 3955                 3960             


Ala Glu  Val Asp Lys Ile Arg  Glu Cys Ile Ser Asp  Asn Lys Ser 
    3965                 3970                 3975             


Ala Thr  Val Glu Leu Glu Lys  Leu Gln Pro Ser Phe  Glu Ala Leu 
    3980                 3985                 3990             


Lys Arg  Arg Gly Glu Glu Leu  Ile Gly Arg Ser Gln  Gly Ala Asp 
    3995                 4000                 4005             


Lys Asp  Leu Ala Ala Lys Glu  Ile Gln Asp Lys Leu  Asp Gln Met 
    4010                 4015                 4020             


Val Phe  Phe Trp Glu Asp Ile  Lys Ala Arg Ala Glu  Glu Arg Glu 
    4025                 4030                 4035             


Ile Lys  Phe Leu Asp Val Leu  Glu Leu Ala Glu Lys  Phe Trp Tyr 
    4040                 4045                 4050             


Asp Met  Ala Ala Leu Leu Thr  Thr Ile Lys Asp Thr  Gln Asp Ile 
    4055                 4060                 4065             


Val His  Asp Leu Glu Ser Pro  Gly Ile Asp Pro Ser  Ile Ile Lys 
    4070                 4075                 4080             


Gln Gln  Val Glu Ala Ala Glu  Thr Ile Lys Glu Glu  Thr Asp Gly 
    4085                 4090                 4095             


Leu His  Glu Glu Leu Glu Phe  Ile Arg Ile Leu Gly  Ala Asp Leu 
    4100                 4105                 4110             


Ile Phe  Ala Cys Gly Glu Thr  Glu Lys Pro Glu Val  Arg Lys Ser 
    4115                 4120                 4125             


Ile Asp  Glu Met Asn Asn Ala  Trp Glu Asn Leu Asn  Lys Thr Trp 
    4130                 4135                 4140             


Lys Glu  Arg Leu Glu Lys Leu  Glu Asp Ala Met Gln  Ala Ala Val 
    4145                 4150                 4155             


Gln Tyr  Gln Asp Thr Leu Gln  Ala Met Phe Asp Trp  Leu Asp Asn 
    4160                 4165                 4170             


Thr Val  Ile Lys Leu Cys Thr  Met Pro Pro Val Gly  Thr Asp Leu 
    4175                 4180                 4185             


Asn Thr  Val Lys Asp Gln Leu  Asn Glu Met Lys Glu  Phe Lys Val 
    4190                 4195                 4200             


Glu Val  Tyr Gln Gln Gln Ile  Glu Met Glu Lys Leu  Asn His Gln 
    4205                 4210                 4215             


Gly Glu  Leu Met Leu Lys Lys  Ala Thr Asp Glu Thr  Asp Arg Asp 
    4220                 4225                 4230             


Ile Ile  Arg Glu Pro Leu Thr  Glu Leu Lys His Leu  Trp Glu Asn 
    4235                 4240                 4245             


Leu Gly  Glu Lys Ile Ala His  Arg Gln His Lys Leu  Glu Gly Ala 
    4250                 4255                 4260             


Leu Leu  Ala Leu Gly Gln Phe  Gln His Ala Leu Glu  Glu Leu Met 
    4265                 4270                 4275             


Ser Trp  Leu Thr His Thr Glu  Glu Leu Leu Asp Ala  Gln Arg Pro 
    4280                 4285                 4290             


Ile Ser  Gly Asp Pro Lys Val  Ile Glu Val Glu Leu  Ala Lys His 
    4295                 4300                 4305             


His Val  Leu Lys Asn Asp Val  Leu Ala His Gln Ala  Thr Val Glu 
    4310                 4315                 4320             


Thr Val  Asn Lys Ala Gly Asn  Glu Leu Leu Glu Ser  Ser Ala Gly 
    4325                 4330                 4335             


Asp Asp  Ala Ser Ser Leu Arg  Ser Arg Leu Glu Ala  Met Asn Gln 
    4340                 4345                 4350             


Cys Trp  Glu Ser Val Leu Gln  Lys Thr Glu Glu Arg  Glu Gln Gln 
    4355                 4360                 4365             


Leu Gln  Ser Thr Leu Gln Gln  Ala Gln Gly Phe His  Ser Glu Ile 
    4370                 4375                 4380             


Glu Asp  Phe Leu Leu Glu Leu  Thr Arg Met Glu Ser  Gln Leu Ser 
    4385                 4390                 4395             


Ala Ser  Lys Pro Thr Gly Gly  Leu Pro Glu Thr Ala  Arg Glu Gln 
    4400                 4405                 4410             


Leu Asp  Thr His Met Glu Leu  Tyr Ser Gln Leu Lys  Ala Lys Glu 
    4415                 4420                 4425             


Glu Thr  Tyr Asn Gln Leu Leu  Asp Lys Gly Arg Leu  Met Leu Leu 
    4430                 4435                 4440             


Ser Arg  Asp Asp Ser Gly Ser  Gly Ser Lys Thr Glu  Gln Ser Val 
    4445                 4450                 4455             


Ala Leu  Leu Glu Gln Lys Trp  His Val Val Ser Ser  Lys Met Glu 
    4460                 4465                 4470             


Glu Arg  Lys Ser Lys Leu Glu  Glu Ala Leu Asn Leu  Ala Thr Glu 
    4475                 4480                 4485             


Phe Gln  Asn Ser Leu Gln Glu  Phe Ile Asn Trp Leu  Thr Leu Ala 
    4490                 4495                 4500             


Glu Gln  Ser Leu Asn Ile Ala  Ser Pro Pro Ser Leu  Ile Leu Asn 
    4505                 4510                 4515             


Thr Val  Leu Ser Gln Ile Glu  Glu His Lys Val Phe  Ala Asn Glu 
    4520                 4525                 4530             


Val Asn  Ala His Arg Asp Gln  Ile Ile Glu Leu Asp  Gln Thr Gly 
    4535                 4540                 4545             


Asn Gln  Leu Lys Phe Leu Ser  Gln Lys Gln Asp Val  Val Leu Ile 
    4550                 4555                 4560             


Lys Asn  Leu Leu Val Ser Val  Gln Ser Arg Trp Glu  Lys Val Val 
    4565                 4570                 4575             


Gln Arg  Ser Ile Glu Arg Gly  Arg Ser Leu Asp Asp  Ala Arg Lys 
    4580                 4585                 4590             


Arg Ala  Lys Gln Phe His Glu  Ala Trp Lys Lys Leu  Ile Asp Trp 
    4595                 4600                 4605             


Leu Glu  Asp Ala Glu Ser His  Leu Asp Ser Glu Leu  Glu Ile Ser 
    4610                 4615                 4620             


Asn Asp  Pro Asp Lys Ile Lys  Leu Gln Leu Ser Lys  His Lys Glu 
    4625                 4630                 4635             


Phe Gln  Lys Thr Leu Gly Gly  Lys Gln Pro Val Tyr  Asp Thr Thr 
    4640                 4645                 4650             


Ile Arg  Thr Gly Arg Ala Leu  Lys Glu Lys Thr Leu  Leu Pro Glu 
    4655                 4660                 4665             


Asp Ser  Gln Lys Leu Asp Asn  Phe Leu Gly Glu Val  Arg Asp Lys 
    4670                 4675                 4680             


Trp Asp  Thr Val Cys Gly Lys  Ser Val Glu Arg Gln  His Lys Leu 
    4685                 4690                 4695             


Glu Glu  Ala Leu Leu Phe Ser  Gly Gln Phe Met Asp  Ala Leu Gln 
    4700                 4705                 4710             


Ala Leu  Val Asp Trp Leu Tyr  Lys Val Glu Pro Gln  Leu Ala Glu 
    4715                 4720                 4725             


Asp Gln  Pro Val His Gly Asp  Leu Asp Leu Val Met  Asn Leu Met 
    4730                 4735                 4740             


Asp Ala  His Lys Val Phe Gln  Lys Glu Leu Gly Lys  Arg Thr Gly 
    4745                 4750                 4755             


Thr Val  Gln Val Leu Lys Arg  Ser Gly Arg Glu Leu  Ile Glu Asn 
    4760                 4765                 4770             


Ser Arg  Asp Asp Thr Thr Trp  Val Lys Gly Gln Leu  Gln Glu Leu 
    4775                 4780                 4785             


Ser Thr  Arg Trp Asp Thr Val  Cys Lys Leu Ser Val  Ser Lys Gln 
    4790                 4795                 4800             


Ser Arg  Leu Glu Gln Ala Leu  Lys Gln Ala Glu Val  Phe Arg Asp 
    4805                 4810                 4815             


Thr Val  His Met Leu Leu Glu  Trp Leu Ser Glu Ala  Glu Gln Thr 
    4820                 4825                 4830             


Leu Arg  Phe Arg Gly Ala Leu  Pro Asp Asp Thr Glu  Ala Leu Gln 
    4835                 4840                 4845             


Ser Leu  Ile Asp Thr His Lys  Glu Phe Met Lys Lys  Val Glu Glu 
    4850                 4855                 4860             


Lys Arg  Val Asp Val Asn Ser  Ala Val Ala Met Gly  Glu Val Ile 
    4865                 4870                 4875             


Leu Ala  Val Cys His Pro Asp  Cys Ile Thr Thr Ile  Lys His Trp 
    4880                 4885                 4890             


Ile Thr  Ile Ile Arg Ala Arg  Phe Glu Glu Val Leu  Thr Trp Ala 
    4895                 4900                 4905             


Lys Gln  His Gln Gln Arg Leu  Glu Thr Ala Leu Ser  Glu Leu Val 
    4910                 4915                 4920             


Ala Asn  Ala Glu Leu Leu Glu  Glu Leu Leu Ala Trp  Ile Gln Trp 
    4925                 4930                 4935             


Ala Glu  Thr Thr Leu Ile Gln  Arg Asp Gln Glu Pro  Ile Pro Gln 
    4940                 4945                 4950             


Asn Ile  Asp Arg Val Lys Ala  Leu Ile Ala Glu His  Gln Thr Phe 
    4955                 4960                 4965             


Met Glu  Glu Met Thr Arg Lys  Gln Pro Asp Val Asp  Arg Val Thr 
    4970                 4975                 4980             


Lys Thr  Tyr Lys Arg Lys Asn  Ile Glu Pro Thr His  Ala Pro Phe 
    4985                 4990                 4995             


Ile Glu  Lys Ser Arg Ser Gly  Gly Arg Lys Ser Leu  Ser Gln Pro 
    5000                 5005                 5010             


Thr Pro  Pro Pro Met Pro Ile  Leu Ser Gln Ser Glu  Ala Lys Asn 
    5015                 5020                 5025             


Pro Arg  Ile Asn Gln Leu Ser  Ala Arg Trp Gln Gln  Val Trp Leu 
    5030                 5035                 5040             


Leu Ala  Leu Glu Arg Gln Arg  Lys Leu Asn Asp Ala  Leu Asp Arg 
    5045                 5050                 5055             


Leu Glu  Glu Leu Lys Glu Phe  Ala Asn Phe Asp Phe  Asp Val Trp 
    5060                 5065                 5070             


Arg Lys  Lys Tyr Met Arg Trp  Met Asn His Lys Lys  Ser Arg Val 
    5075                 5080                 5085             


Met Asp  Phe Phe Arg Arg Ile  Asp Lys Asp Gln Asp  Gly Lys Ile 
    5090                 5095                 5100             


Thr Arg  Gln Glu Phe Ile Asp  Gly Ile Leu Ala Ser  Lys Phe Pro 
    5105                 5110                 5115             


Thr Thr  Lys Leu Glu Met Thr  Ala Val Ala Asp Ile  Phe Asp Arg 
    5120                 5125                 5130             


Asp Gly  Asp Gly Tyr Ile Asp  Tyr Tyr Glu Phe Val  Ala Ala Leu 
    5135                 5140                 5145             


His Pro  Asn Lys Asp Ala Tyr  Arg Pro Thr Thr Asp  Ala Asp Lys 
    5150                 5155                 5160             


Ile Glu  Asp Glu Val Thr Arg  Gln Val Ala Gln Cys  Lys Cys Ala 
    5165                 5170                 5175             


Lys Arg  Phe Gln Val Glu Gln  Ile Gly Glu Asn Lys  Tyr Arg Phe 
    5180                 5185                 5190             


Gly Asp  Ser Gln Gln Leu Arg  Leu Val Arg Ile Leu  Arg Ser Thr 
    5195                 5200                 5205             


Val Met  Val Arg Val Gly Gly  Gly Trp Met Ala Leu  Asp Glu Phe 
    5210                 5215                 5220             


Leu Val  Lys Asn Asp Pro Cys  Arg Ala Arg Gly Arg  Thr Asn Ile 
    5225                 5230                 5235             


Glu Leu  Arg Glu Lys Phe Ile  Leu Pro Glu Gly Ala  Ser Gln Gly 
    5240                 5245                 5250             


Met Thr  Pro Phe Arg Ser Arg  Gly Arg Arg Ser Lys  Pro Ser Ser 
    5255                 5260                 5265             


Arg Ala  Ala Ser Pro Thr Arg  Ser Ser Ser Ser Ala  Ser Gln Ser 
    5270                 5275                 5280             


Asn His  Ser Cys Thr Ser Met  Pro Ser Ser Pro Ala  Thr Pro Ala 
    5285                 5290                 5295             


Ser Gly  Thr Lys Val Ile Pro  Ser Ser Gly Ser Lys  Leu Lys Arg 
    5300                 5305                 5310             


Pro Thr  Pro Thr Phe His Ser  Ser Arg Thr Ser Leu  Ala Gly Asp 
    5315                 5320                 5325             


Thr Ser  Asn Ser Ser Ser Pro  Ala Ser Thr Gly Ala  Lys Thr Asn 
    5330                 5335                 5340             


Arg Ala  Asp Pro Lys Lys Ser  Ala Ser Arg Pro Gly  Ser Arg Ala 
    5345                 5350                 5355             


Gly Ser  Arg Ala Gly Ser Arg  Ala Ser Ser Arg Arg  Gly Ser Asp 
    5360                 5365                 5370             


Ala Ser  Asp Phe Asp Leu Leu  Glu Thr Gln Ser Ala  Cys Ser Asp 
    5375                 5380                 5385             


Thr Ser  Glu Ser Ser Ala Ala  Gly Gly Gln Gly Asn  Ser Arg Arg 
    5390                 5395                 5400             


Gly Leu  Asn Lys Pro Ser Lys  Ile Pro Thr Met Ser  Lys Lys Thr 
    5405                 5410                 5415             


Thr Thr  Ala Ser Pro Arg Thr  Pro Gly Pro Lys Arg  
    5420                 5425                 5430 


<210>  3703
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  3703

Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys 
1               5                   10                  15      


Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro 
    130                 135                 140                 


Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu 
145                 150                 155                 160 


Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro 
                165                 170                 175     


Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser 
            180                 185                 190         


Arg Leu Thr Asp Val Thr Leu 
        195                 


<210>  3704
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  3704

Met Ala Gln Ala Leu Pro Trp Leu Leu Leu Trp Met Gly Ala Gly Val 
1               5                   10                  15      


Leu Pro Ala His Gly Thr Gln His Gly Ile Arg Leu Pro Leu Arg Ser 
            20                  25                  30          


Gly Leu Gly Gly Ala Pro Leu Gly Leu Arg Leu Pro Arg Glu Thr Asp 
        35                  40                  45              


Glu Glu Pro Glu Glu Pro Gly Arg Arg Gly Ser Phe Val Glu Met Val 
    50                  55                  60                  


Asp Asn Leu Arg Gly Lys Ser Gly Gln Gly Tyr Tyr Val Glu Met Thr 
65                  70                  75                  80  


Val Gly Ser Pro Pro Gln Thr Leu Asn Ile Leu Val Asp Thr Gly Ser 
                85                  90                  95      


Ser Asn Phe Ala Val Gly Ala Ala Pro His Pro Phe Leu His Arg Tyr 
            100                 105                 110         


Tyr Gln Arg Gln Leu Ser Ser Thr Tyr Arg Asp Leu Arg Lys Gly Val 
        115                 120                 125             


Tyr Val Pro Tyr Thr Gln Gly Lys Trp Glu Gly Glu Leu Gly Thr Asp 
    130                 135                 140                 


Leu Val Ser Ile Pro His Gly Pro Asn Val Thr Val Arg Ala Asn Ile 
145                 150                 155                 160 


Ala Ala Ile Thr Glu Ser Asp Lys Phe Phe Ile Asn Gly Ser Asn Trp 
                165                 170                 175     


Glu Gly Ile Leu Gly Leu Ala Tyr Ala Glu Ile Ala Arg Pro Asp Asp 
            180                 185                 190         


Ser Leu Glu Pro Phe Phe Asp Ser Leu Val Lys Gln Thr His Val Pro 
        195                 200                 205             


Asn Leu Phe Ser Leu Gln Leu Cys Gly Ala Gly Phe Pro Leu Asn Gln 
    210                 215                 220                 


Ser Glu Val Leu Ala Ser Val Gly Gly Ser Met Ile Ile Gly Gly Ile 
225                 230                 235                 240 


Asp His Ser Leu Tyr Thr Gly Ser Leu Trp Tyr Thr Pro Ile Arg Arg 
                245                 250                 255     


Glu Trp Tyr Tyr Glu Val Ile Ile Val Arg Val Glu Ile Asn Gly Gln 
            260                 265                 270         


Asp Leu Lys Met Asp Cys Lys Glu Tyr Asn Tyr Asp Lys Ser Ile Val 
        275                 280                 285             


Asp Ser Gly Thr Thr Asn Leu Arg Leu Pro Lys Lys Val Phe Glu Ala 
    290                 295                 300                 


Ala Val Lys Ser Ile Lys Ala Ala Ser Ser Thr Glu Lys Phe Pro Asp 
305                 310                 315                 320 


Gly Phe Trp Leu Gly Glu Gln Leu Val Cys Trp Gln Ala Gly Thr Thr 
                325                 330                 335     


Pro Trp Asn Ile Phe Pro Val Ile Ser Leu Tyr Leu Met Gly Glu Val 
            340                 345                 350         


Thr Asn Gln Ser Phe Arg Ile Thr Ile Leu Pro Gln Gln Tyr Leu Arg 
        355                 360                 365             


Pro Val Glu Asp Val Ala Thr Ser Gln Asp Asp Cys Tyr Lys Phe Ala 
    370                 375                 380                 


Ile Ser Gln Ser Ser Thr Gly Thr Val Met Gly Ala Val Ile Met Glu 
385                 390                 395                 400 


Gly Phe Tyr Val Val Phe Asp Arg Ala Arg Lys Arg Ile Gly Phe Ala 
                405                 410                 415     


Val Ser Ala Cys His Val His Asp Glu Phe Arg Thr Ala Ala Val Glu 
            420                 425                 430         


Gly Pro Phe Val Thr Leu Asp Met Glu Asp Cys Gly Tyr Asn Ile Pro 
        435                 440                 445             


Gln Thr Asp Glu Ser Thr Leu Met Thr Ile Ala Tyr Val Met Ala Ala 
    450                 455                 460                 


Ile Cys Ala Leu Phe Met Leu Pro Leu Cys Leu Met Val Cys Gln Trp 
465                 470                 475                 480 


Arg Cys Leu Arg Cys Leu Arg Gln Gln His Asp Asp Phe Ala Asp Asp 
                485                 490                 495     


Ile Ser Leu Leu Lys 
            500     


<210>  3705
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  3705

Met Gly Ala Leu Ala Arg Ala Leu Leu Leu Pro Leu Leu Ala Gln Trp 
1               5                   10                  15      


Leu Leu Arg Ala Ala Pro Glu Leu Ala Pro Ala Pro Phe Thr Leu Pro 
            20                  25                  30          


Leu Arg Val Ala Ala Ala Thr Asn Arg Val Val Ala Pro Thr Pro Gly 
        35                  40                  45              


Pro Gly Thr Pro Ala Glu Arg His Ala Asp Gly Leu Ala Leu Ala Leu 
    50                  55                  60                  


Glu Pro Ala Leu Ala Ser Pro Ala Gly Ala Ala Asn Phe Leu Ala Met 
65                  70                  75                  80  


Val Asp Asn Leu Gln Gly Asp Ser Gly Arg Gly Tyr Tyr Leu Glu Met 
                85                  90                  95      


Leu Ile Gly Thr Pro Pro Gln Lys Leu Gln Ile Leu Val Asp Thr Gly 
            100                 105                 110         


Ser Ser Asn Phe Ala Val Ala Gly Thr Pro His Ser Tyr Ile Asp Thr 
        115                 120                 125             


Tyr Phe Asp Thr Glu Arg Ser Ser Thr Tyr Arg Ser Lys Gly Phe Asp 
    130                 135                 140                 


Val Thr Val Lys Tyr Thr Gln Gly Ser Trp Thr Gly Phe Val Gly Glu 
145                 150                 155                 160 


Asp Leu Val Thr Ile Pro Lys Gly Phe Asn Thr Ser Phe Leu Val Asn 
                165                 170                 175     


Ile Ala Thr Ile Phe Glu Ser Glu Asn Phe Phe Leu Pro Gly Ile Lys 
            180                 185                 190         


Trp Asn Gly Ile Leu Gly Leu Ala Tyr Ala Thr Leu Ala Lys Pro Ser 
        195                 200                 205             


Ser Ser Leu Glu Thr Phe Phe Asp Ser Leu Val Thr Gln Ala Asn Ile 
    210                 215                 220                 


Pro Asn Val Phe Ser Met Gln Met Cys Gly Ala Gly Leu Pro Val Ala 
225                 230                 235                 240 


Gly Ser Gly Thr Asn Gly Gly Ser Leu Val Leu Gly Gly Ile Glu Pro 
                245                 250                 255     


Ser Leu Tyr Lys Gly Asp Ile Trp Tyr Thr Pro Ile Lys Glu Glu Trp 
            260                 265                 270         


Tyr Tyr Gln Ile Glu Ile Leu Lys Leu Glu Ile Gly Gly Gln Ser Leu 
        275                 280                 285             


Asn Leu Asp Cys Arg Glu Tyr Asn Ala Asp Lys Ala Ile Val Asp Ser 
    290                 295                 300                 


Gly Thr Thr Leu Leu Arg Leu Pro Gln Lys Val Phe Asp Ala Val Val 
305                 310                 315                 320 


Glu Ala Val Ala Arg Ala Ser Leu Ile Pro Glu Phe Ser Asp Gly Phe 
                325                 330                 335     


Trp Thr Gly Ser Gln Leu Ala Cys Trp Thr Asn Ser Glu Thr Pro Trp 
            340                 345                 350         


Ser Tyr Phe Pro Lys Ile Ser Ile Tyr Leu Arg Asp Glu Asn Ser Ser 
        355                 360                 365             


Arg Ser Phe Arg Ile Thr Ile Leu Pro Gln Leu Tyr Ile Gln Pro Met 
    370                 375                 380                 


Met Gly Ala Gly Leu Asn Tyr Glu Cys Tyr Arg Phe Gly Ile Ser Pro 
385                 390                 395                 400 


Ser Thr Asn Ala Leu Val Ile Gly Ala Thr Val Met Glu Gly Phe Tyr 
                405                 410                 415     


Val Ile Phe Asp Arg Ala Gln Lys Arg Val Gly Phe Ala Ala Ser Pro 
            420                 425                 430         


Cys Ala Glu Ile Ala Gly Ala Ala Val Ser Glu Ile Ser Gly Pro Phe 
        435                 440                 445             


Ser Thr Glu Asp Val Ala Ser Asn Cys Val Pro Ala Gln Ser Leu Ser 
    450                 455                 460                 


Glu Pro Ile Leu Trp Ile Val Ser Tyr Ala Leu Met Ser Val Cys Gly 
465                 470                 475                 480 


Ala Ile Leu Leu Val Leu Ile Val Leu Leu Leu Leu Pro Phe Arg Cys 
                485                 490                 495     


Gln Arg Arg Pro Arg Asp Pro Glu Val Val Asn Asp Glu Ser Ser Leu 
            500                 505                 510         


Val Arg His Arg Trp Lys 
        515             


<210>  3706
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  3706

Met Ala Ala Val Ala Leu Met Pro Pro Pro Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Ser Pro Pro Ala Ala Ser Ala Pro Ser Ala Arg Asp Pro Phe 
            20                  25                  30          


Ala Pro Gln Leu Gly Asp Thr Gln Asn Cys Gln Leu Arg Cys Arg Asp 
        35                  40                  45              


Arg Asp Leu Gly Pro Gln Pro Ser Gln Ala Gly Leu Glu Gly Ala Ser 
    50                  55                  60                  


Glu Ser Pro Tyr Asp Arg Ala Val Leu Ile Ser Ala Cys Glu Arg Gly 
65                  70                  75                  80  


Cys Arg Leu Phe Ser Ile Cys Arg Phe Val Ala Arg Ser Ser Lys Pro 
                85                  90                  95      


Asn Ala Thr Gln Thr Glu Cys Glu Ala Ala Cys Val Glu Ala Tyr Val 
            100                 105                 110         


Lys Glu Ala Glu Gln Gln Ala Cys Ser His Gly Cys Trp Ser Gln Pro 
        115                 120                 125             


Ala Glu Pro Glu Pro Glu Gln Lys Arg Lys Val Leu Glu Ala Pro Ser 
    130                 135                 140                 


Gly Ala Leu Ser Leu Leu Asp Leu Phe Ser Thr Leu Cys Asn Asp Leu 
145                 150                 155                 160 


Val Asn Ser Ala Gln Gly Phe Val Ser Ser Thr Trp Thr Tyr Tyr Leu 
                165                 170                 175     


Gln Thr Asp Asn Gly Lys Val Val Val Phe Gln Thr Gln Pro Ile Val 
            180                 185                 190         


Glu Ser Leu Gly Phe Gln Gly Gly Arg Leu Gln Arg Val Glu Val Thr 
        195                 200                 205             


Trp Arg Gly Ser His Pro Glu Ala Leu Glu Val His Val Asp Pro Val 
    210                 215                 220                 


Gly Pro Leu Asp Lys Val Arg Lys Ala Lys Ile Arg Val Lys Thr Ser 
225                 230                 235                 240 


Ser Lys Ala Lys Val Glu Ser Glu Glu Pro Gln Asp Asn Asp Phe Leu 
                245                 250                 255     


Ser Cys Met Ser Arg Arg Ser Gly Leu Pro Arg Trp Ile Leu Ala Cys 
            260                 265                 270         


Cys Leu Phe Leu Ser Val Leu Val Met Leu Trp Leu Ser Cys Ser Thr 
        275                 280                 285             


Leu Val Thr Ala Pro Gly Gln His Leu Lys Phe Gln Pro Leu Thr Leu 
    290                 295                 300                 


Glu Gln His Lys Gly Phe Met Met Glu Pro Asp Trp Pro Leu Tyr Pro 
305                 310                 315                 320 


Pro Pro Ser His Ala Cys Glu Asp Ser Leu Pro Pro Tyr Lys Leu Lys 
                325                 330                 335     


Leu Asp Leu Thr Lys Leu 
            340         


<210>  3707
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  3707

Met Ala Asp Phe Asp Glu Ile Tyr Glu Glu Glu Glu Asp Glu Glu Arg 
1               5                   10                  15      


Ala Leu Glu Glu Gln Leu Leu Lys Tyr Ser Pro Asp Pro Val Val Val 
            20                  25                  30          


Arg Gly Ser Gly His Val Thr Val Phe Gly Leu Ser Asn Lys Phe Glu 
        35                  40                  45              


Ser Glu Phe Pro Ser Ser Leu Thr Gly Lys Val Ala Pro Glu Glu Phe 
    50                  55                  60                  


Lys Ala Ser Ile Asn Arg Val Asn Ser Cys Leu Lys Lys Asn Leu Pro 
65                  70                  75                  80  


Val Asn Val Arg Trp Leu Leu Cys Gly Cys Leu Cys Cys Cys Cys Thr 
                85                  90                  95      


Leu Gly Cys Ser Met Trp Pro Val Ile Cys Leu Ser Lys Arg Thr Arg 
            100                 105                 110         


Arg Ser Ile Glu Lys Leu Leu Glu Trp Glu Asn Asn Arg Leu Tyr His 
        115                 120                 125             


Lys Leu Cys Leu His Trp Arg Leu Ser Lys Arg Lys Cys Glu Thr Asn 
    130                 135                 140                 


Asn Met Met Glu Tyr Val Ile Leu Ile Glu Phe Leu Pro Lys Thr Pro 
145                 150                 155                 160 


Ile Phe Arg Pro Asp 
                165 


<210>  3708
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  3708

Met Leu Phe Ser Ala Leu Leu Leu Glu Val Ile Trp Ile Leu Ala Ala 
1               5                   10                  15      


Asp Gly Gly Gln His Trp Thr Tyr Glu Gly Pro His Gly Gln Asp His 
            20                  25                  30          


Trp Pro Ala Ser Tyr Pro Glu Cys Gly Asn Asn Ala Gln Ser Pro Ile 
        35                  40                  45              


Asp Ile Gln Thr Asp Ser Val Thr Phe Asp Pro Asp Leu Pro Ala Leu 
    50                  55                  60                  


Gln Pro His Gly Tyr Asp Gln Pro Gly Thr Glu Pro Leu Asp Leu His 
65                  70                  75                  80  


Asn Asn Gly His Thr Val Gln Leu Ser Leu Pro Ser Thr Leu Tyr Leu 
                85                  90                  95      


Gly Gly Leu Pro Arg Lys Tyr Val Ala Ala Gln Leu His Leu His Trp 
            100                 105                 110         


Gly Gln Lys Gly Ser Pro Gly Gly Ser Glu His Gln Ile Asn Ser Glu 
        115                 120                 125             


Ala Thr Phe Ala Glu Leu His Ile Val His Tyr Asp Ser Asp Ser Tyr 
    130                 135                 140                 


Asp Ser Leu Ser Glu Ala Ala Glu Arg Pro Gln Gly Leu Ala Val Leu 
145                 150                 155                 160 


Gly Ile Leu Ile Glu Val Gly Glu Thr Lys Asn Ile Ala Tyr Glu His 
                165                 170                 175     


Ile Leu Ser His Leu His Glu Val Arg His Lys Asp Gln Lys Thr Ser 
            180                 185                 190         


Val Pro Pro Phe Asn Leu Arg Glu Leu Leu Pro Lys Gln Leu Gly Gln 
        195                 200                 205             


Tyr Phe Arg Tyr Asn Gly Ser Leu Thr Thr Pro Pro Cys Tyr Gln Ser 
    210                 215                 220                 


Val Leu Trp Thr Val Phe Tyr Arg Arg Ser Gln Ile Ser Met Glu Gln 
225                 230                 235                 240 


Leu Glu Lys Leu Gln Gly Thr Leu Phe Ser Thr Glu Glu Glu Pro Ser 
                245                 250                 255     


Lys Leu Leu Val Gln Asn Tyr Arg Ala Leu Gln Pro Leu Asn Gln Arg 
            260                 265                 270         


Met Val Phe Ala Ser Phe Ile Gln Ala Gly Ser Ser Tyr Thr Thr Gly 
        275                 280                 285             


Glu Met Leu Ser Leu Gly Val Gly Ile Leu Val Gly Cys Leu Cys Leu 
    290                 295                 300                 


Leu Leu Ala Val Tyr Phe Ile Ala Arg Lys Ile Arg Lys Lys Arg Leu 
305                 310                 315                 320 


Glu Asn Arg Lys Ser Val Val Phe Thr Ser Ala Gln Ala Thr Thr Glu 
                325                 330                 335     


Ala 
    


<210>  3709
<211>  532
<212>  PRT
<213>  Homo sapiens

<400>  3709

Met Glu Gly Asp Ser Tyr His Asn Ala Thr Thr Val Asn Gly Thr Pro 
1               5                   10                  15      


Val Asn His Gln Pro Leu Glu Arg His Arg Leu Trp Glu Val Ile Thr 
            20                  25                  30          


Ile Ala Ala Val Thr Ala Val Val Ser Leu Ile Thr Ile Val Gly Asn 
        35                  40                  45              


Val Leu Val Met Ile Ser Phe Lys Val Asn Ser Gln Leu Lys Thr Val 
    50                  55                  60                  


Asn Asn Tyr Tyr Leu Leu Ser Leu Ala Cys Ala Asp Leu Ile Ile Gly 
65                  70                  75                  80  


Ile Phe Ser Met Asn Leu Tyr Thr Thr Tyr Ile Leu Met Gly Arg Trp 
                85                  90                  95      


Ala Leu Gly Ser Leu Ala Cys Asp Leu Trp Leu Ala Leu Asp Tyr Val 
            100                 105                 110         


Ala Ser Asn Ala Ser Val Met Asn Leu Leu Val Ile Ser Phe Asp Arg 
        115                 120                 125             


Tyr Phe Ser Ile Thr Arg Pro Leu Thr Tyr Arg Ala Lys Arg Thr Pro 
    130                 135                 140                 


Lys Arg Ala Gly Ile Met Ile Gly Leu Ala Trp Leu Ile Ser Phe Ile 
145                 150                 155                 160 


Leu Trp Ala Pro Ala Ile Leu Cys Trp Gln Tyr Leu Val Gly Lys Arg 
                165                 170                 175     


Thr Val Pro Leu Asp Glu Cys Gln Ile Gln Phe Leu Ser Glu Pro Thr 
            180                 185                 190         


Ile Thr Phe Gly Thr Ala Ile Ala Ala Phe Tyr Ile Pro Val Ser Val 
        195                 200                 205             


Met Thr Ile Leu Tyr Cys Arg Ile Tyr Arg Glu Thr Glu Lys Arg Thr 
    210                 215                 220                 


Lys Asp Leu Ala Asp Leu Gln Gly Ser Asp Ser Val Thr Lys Ala Glu 
225                 230                 235                 240 


Lys Arg Lys Pro Ala His Arg Ala Leu Phe Arg Ser Cys Leu Arg Cys 
                245                 250                 255     


Pro Arg Pro Thr Leu Ala Gln Arg Glu Arg Asn Gln Ala Ser Trp Ser 
            260                 265                 270         


Ser Ser Arg Arg Ser Thr Ser Thr Thr Gly Lys Pro Ser Gln Ala Thr 
        275                 280                 285             


Gly Pro Ser Ala Asn Trp Ala Lys Ala Glu Gln Leu Thr Thr Cys Ser 
    290                 295                 300                 


Ser Tyr Pro Ser Ser Glu Asp Glu Asp Lys Pro Ala Thr Asp Pro Val 
305                 310                 315                 320 


Leu Gln Val Val Tyr Lys Ser Gln Gly Lys Glu Ser Pro Gly Glu Glu 
                325                 330                 335     


Phe Ser Ala Glu Glu Thr Glu Glu Thr Phe Val Lys Ala Glu Thr Glu 
            340                 345                 350         


Lys Ser Asp Tyr Asp Thr Pro Asn Tyr Leu Leu Ser Pro Ala Ala Ala 
        355                 360                 365             


His Arg Pro Lys Ser Gln Lys Cys Val Ala Tyr Lys Phe Arg Leu Val 
    370                 375                 380                 


Val Lys Ala Asp Gly Asn Gln Glu Thr Asn Asn Gly Cys His Lys Val 
385                 390                 395                 400 


Lys Ile Met Pro Cys Pro Phe Pro Val Ala Lys Glu Pro Ser Thr Lys 
                405                 410                 415     


Gly Leu Asn Pro Asn Pro Ser His Gln Met Thr Lys Arg Lys Arg Val 
            420                 425                 430         


Val Leu Val Lys Glu Arg Lys Ala Ala Gln Thr Leu Ser Ala Ile Leu 
        435                 440                 445             


Leu Ala Phe Ile Ile Thr Trp Thr Pro Tyr Asn Ile Met Val Leu Val 
    450                 455                 460                 


Ser Thr Phe Cys Asp Lys Cys Val Pro Val Thr Leu Trp His Leu Gly 
465                 470                 475                 480 


Tyr Trp Leu Cys Tyr Val Asn Ser Thr Val Asn Pro Ile Cys Tyr Ala 
                485                 490                 495     


Leu Cys Asn Arg Thr Phe Arg Lys Thr Phe Lys Met Leu Leu Leu Cys 
            500                 505                 510         


Arg Trp Lys Lys Lys Lys Val Glu Glu Lys Leu Tyr Trp Gln Gly Asn 
        515                 520                 525             


Ser Lys Leu Pro 
    530         


<210>  3710
<211>  919
<212>  PRT
<213>  Homo sapiens

<400>  3710

Met Gly Leu Phe Arg Gly Phe Val Phe Leu Leu Val Leu Cys Leu Leu 
1               5                   10                  15      


His Gln Ser Asn Thr Ser Phe Ile Lys Leu Asn Asn Asn Gly Phe Glu 
            20                  25                  30          


Asp Ile Val Ile Val Ile Asp Pro Ser Val Pro Glu Asp Glu Lys Ile 
        35                  40                  45              


Ile Glu Gln Ile Glu Asp Met Val Thr Thr Ala Ser Thr Tyr Leu Phe 
    50                  55                  60                  


Glu Ala Thr Glu Lys Arg Phe Phe Phe Lys Asn Val Ser Ile Leu Ile 
65                  70                  75                  80  


Pro Glu Asn Trp Lys Glu Asn Pro Gln Tyr Lys Arg Pro Lys His Glu 
                85                  90                  95      


Asn His Lys His Ala Asp Val Ile Val Ala Pro Pro Thr Leu Pro Gly 
            100                 105                 110         


Arg Asp Glu Pro Tyr Thr Lys Gln Phe Thr Glu Cys Gly Glu Lys Gly 
        115                 120                 125             


Glu Tyr Ile His Phe Thr Pro Asp Leu Leu Leu Gly Lys Lys Gln Asn 
    130                 135                 140                 


Glu Tyr Gly Pro Pro Gly Lys Leu Phe Val His Glu Trp Ala His Leu 
145                 150                 155                 160 


Arg Trp Gly Val Phe Asp Glu Tyr Asn Glu Asp Gln Pro Phe Tyr Arg 
                165                 170                 175     


Ala Lys Ser Lys Lys Ile Glu Ala Thr Arg Cys Ser Ala Gly Ile Ser 
            180                 185                 190         


Gly Arg Asn Arg Val Tyr Lys Cys Gln Gly Gly Ser Cys Leu Ser Arg 
        195                 200                 205             


Ala Cys Arg Ile Asp Ser Thr Thr Lys Leu Tyr Gly Lys Asp Cys Gln 
    210                 215                 220                 


Phe Phe Pro Asp Lys Val Gln Thr Glu Lys Ala Ser Ile Met Phe Met 
225                 230                 235                 240 


Gln Ser Ile Asp Ser Val Val Glu Phe Cys Asn Glu Lys Thr His Asn 
                245                 250                 255     


Gln Glu Ala Pro Ser Leu Gln Asn Ile Lys Cys Asn Phe Arg Ser Thr 
            260                 265                 270         


Trp Glu Val Ile Ser Asn Ser Glu Asp Phe Lys Asn Thr Ile Pro Met 
        275                 280                 285             


Val Thr Pro Pro Pro Pro Pro Val Phe Ser Leu Leu Lys Ile Ser Gln 
    290                 295                 300                 


Arg Ile Val Cys Leu Val Leu Asp Lys Ser Gly Ser Met Gly Gly Lys 
305                 310                 315                 320 


Asp Arg Leu Asn Arg Met Asn Gln Ala Ala Lys His Phe Leu Leu Gln 
                325                 330                 335     


Thr Val Glu Asn Gly Ser Trp Val Gly Met Val His Phe Asp Ser Thr 
            340                 345                 350         


Ala Thr Ile Val Asn Lys Leu Ile Gln Ile Lys Ser Ser Asp Glu Arg 
        355                 360                 365             


Asn Thr Leu Met Ala Gly Leu Pro Thr Tyr Pro Leu Gly Gly Thr Ser 
    370                 375                 380                 


Ile Cys Ser Gly Ile Lys Tyr Ala Phe Gln Val Ile Gly Glu Leu His 
385                 390                 395                 400 


Ser Gln Leu Asp Gly Ser Glu Val Leu Leu Leu Thr Asp Gly Glu Asp 
                405                 410                 415     


Asn Thr Ala Ser Ser Cys Ile Asp Glu Val Lys Gln Ser Gly Ala Ile 
            420                 425                 430         


Val His Phe Ile Ala Leu Gly Arg Ala Ala Asp Glu Ala Val Ile Glu 
        435                 440                 445             


Met Ser Lys Ile Thr Gly Gly Ser His Phe Tyr Val Ser Asp Glu Ala 
    450                 455                 460                 


Gln Asn Asn Gly Leu Ile Asp Ala Phe Gly Ala Leu Thr Ser Gly Asn 
465                 470                 475                 480 


Thr Asp Leu Ser Gln Lys Ser Leu Gln Leu Glu Ser Lys Gly Leu Thr 
                485                 490                 495     


Leu Asn Ser Asn Ala Trp Met Asn Asp Thr Val Ile Ile Asp Ser Thr 
            500                 505                 510         


Val Gly Lys Asp Thr Phe Phe Leu Ile Thr Trp Asn Ser Leu Pro Pro 
        515                 520                 525             


Ser Ile Ser Leu Trp Asp Pro Ser Gly Thr Ile Met Glu Asn Phe Thr 
    530                 535                 540                 


Val Asp Ala Thr Ser Lys Met Ala Tyr Leu Ser Ile Pro Gly Thr Ala 
545                 550                 555                 560 


Lys Val Gly Thr Trp Ala Tyr Asn Leu Gln Ala Lys Ala Asn Pro Glu 
                565                 570                 575     


Thr Leu Thr Ile Thr Val Thr Ser Arg Ala Ala Asn Ser Ser Val Pro 
            580                 585                 590         


Pro Ile Thr Val Asn Ala Lys Met Asn Lys Asp Val Asn Ser Phe Pro 
        595                 600                 605             


Ser Pro Met Ile Val Tyr Ala Glu Ile Leu Gln Gly Tyr Val Pro Val 
    610                 615                 620                 


Leu Gly Ala Asn Val Thr Ala Phe Ile Glu Ser Gln Asn Gly His Thr 
625                 630                 635                 640 


Glu Val Leu Glu Leu Leu Asp Asn Gly Ala Gly Ala Asp Ser Phe Lys 
                645                 650                 655     


Asn Asp Gly Val Tyr Ser Arg Tyr Phe Thr Ala Tyr Thr Glu Asn Gly 
            660                 665                 670         


Arg Tyr Ser Leu Lys Val Arg Ala His Gly Gly Ala Asn Thr Ala Arg 
        675                 680                 685             


Leu Lys Leu Arg Pro Pro Leu Asn Arg Ala Ala Tyr Ile Pro Gly Trp 
    690                 695                 700                 


Val Val Asn Gly Glu Ile Glu Ala Asn Pro Pro Arg Pro Glu Ile Asp 
705                 710                 715                 720 


Glu Asp Thr Gln Thr Thr Leu Glu Asp Phe Ser Arg Thr Ala Ser Gly 
                725                 730                 735     


Gly Ala Phe Val Val Ser Gln Val Pro Ser Leu Pro Leu Pro Asp Gln 
            740                 745                 750         


Tyr Pro Pro Ser Gln Ile Thr Asp Leu Asp Ala Thr Val His Glu Asp 
        755                 760                 765             


Lys Ile Ile Leu Thr Trp Thr Ala Pro Gly Asp Asn Phe Asp Val Gly 
    770                 775                 780                 


Lys Val Gln Arg Tyr Ile Ile Arg Ile Ser Ala Ser Ile Leu Asp Leu 
785                 790                 795                 800 


Arg Asp Ser Phe Asp Asp Ala Leu Gln Val Asn Thr Thr Asp Leu Ser 
                805                 810                 815     


Pro Lys Glu Ala Asn Ser Lys Glu Ser Phe Ala Phe Lys Pro Glu Asn 
            820                 825                 830         


Ile Ser Glu Glu Asn Ala Thr His Ile Phe Ile Ala Ile Lys Ser Ile 
        835                 840                 845             


Asp Lys Ser Asn Leu Thr Ser Lys Val Ser Asn Ile Ala Gln Val Thr 
    850                 855                 860                 


Leu Phe Ile Pro Gln Ala Asn Pro Asp Asp Ile Asp Pro Thr Pro Thr 
865                 870                 875                 880 


Pro Thr Pro Thr Pro Thr Pro Asp Lys Ser His Asn Ser Gly Val Asn 
                885                 890                 895     


Ile Ser Thr Leu Val Leu Ser Val Ile Gly Ser Val Val Ile Val Asn 
            900                 905                 910         


Phe Ile Leu Ser Thr Thr Ile 
        915                 


<210>  3711
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  3711

Met Gly Cys Arg Asp Val His Ala Ala Thr Val Leu Ser Phe Leu Cys 
1               5                   10                  15      


Gly Ile Ala Ser Val Ala Gly Leu Phe Ala Gly Thr Leu Leu Pro Asn 
            20                  25                  30          


Trp Arg Lys Leu Arg Leu Ile Thr Phe Asn Arg Asn Glu Lys Asn Leu 
        35                  40                  45              


Thr Val Tyr Thr Gly Leu Trp Val Lys Cys Ala Arg Tyr Asp Gly Ser 
    50                  55                  60                  


Ser Asp Cys Leu Met Tyr Asp Thr Thr Trp Tyr Ser Ser Val Asp Gln 
65                  70                  75                  80  


Leu Asp Leu Arg Val Leu Gln Phe Ala Leu Pro Leu Ser Met Leu Ile 
                85                  90                  95      


Ala Met Gly Ala Leu Leu Leu Cys Leu Ile Gly Met Cys Asn Thr Ala 
            100                 105                 110         


Phe Arg Ser Ser Val Pro Asn Ile Lys Leu Ala Lys Cys Leu Val Asn 
        115                 120                 125             


Ser Ala Gly Cys His Leu Val Ala Gly Leu Leu Phe Phe Leu Ala Gly 
    130                 135                 140                 


Thr Val Ser Leu Ser Pro Ser Ile Trp Val Ile Phe Tyr Asn Ile His 
145                 150                 155                 160 


Leu Asn Lys Lys Phe Glu Pro Val Phe Ser Phe Asp Tyr Ala Val Tyr 
                165                 170                 175     


Val Thr Ile Ala Ser Ala Gly Gly Leu Phe Met Thr Ser Leu Ile Leu 
            180                 185                 190         


Phe Ile Trp Tyr Cys Thr Cys Lys Ser Leu Pro Ser Pro Phe Trp Gln 
        195                 200                 205             


Pro Leu Tyr Ser His Pro Pro Ser Met His Thr Tyr Ser Gln Pro Tyr 
    210                 215                 220                 


Ser Ala Arg Ser Arg Leu Ser Ala Ile Glu Ile Asp Ile Pro Val Val 
225                 230                 235                 240 


Ser His Thr Thr 
                


<210>  3712
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  3712

Met Ala Ser Thr Ala Val Gln Leu Leu Gly Phe Leu Leu Ser Phe Leu 
1               5                   10                  15      


Gly Met Val Gly Thr Leu Ile Thr Thr Ile Leu Pro His Trp Arg Arg 
            20                  25                  30          


Thr Ala His Val Gly Thr Asn Ile Leu Thr Ala Val Ser Tyr Leu Lys 
        35                  40                  45              


Gly Leu Trp Met Glu Cys Val Trp His Ser Thr Gly Ile Tyr Gln Cys 
    50                  55                  60                  


Gln Ile Tyr Arg Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala 
65                  70                  75                  80  


Arg Ala Leu Met Val Ile Ser Cys Leu Leu Ser Gly Ile Ala Cys Ala 
                85                  90                  95      


Cys Ala Val Ile Gly Met Lys Cys Thr Arg Cys Ala Lys Gly Thr Pro 
            100                 105                 110         


Ala Lys Thr Thr Phe Ala Ile Leu Gly Gly Thr Leu Phe Ile Leu Ala 
        115                 120                 125             


Gly Leu Leu Cys Met Val Ala Val Ser Trp Thr Thr Asn Asp Val Val 
    130                 135                 140                 


Gln Asn Phe Tyr Asn Pro Leu Leu Pro Ser Gly Met Lys Phe Glu Ile 
145                 150                 155                 160 


Gly Gln Ala Leu Tyr Leu Gly Phe Ile Ser Ser Ser Leu Ser Leu Ile 
                165                 170                 175     


Gly Gly Thr Leu Leu Cys Leu Ser Cys Gln Asp Glu Ala Pro Tyr Arg 
            180                 185                 190         


Pro Tyr Gln Ala Pro Pro Arg Ala Thr Thr Thr Thr Ala Asn Thr Ala 
        195                 200                 205             


Pro Ala Tyr Gln Pro Pro Ala Ala Tyr Lys Asp Asn Arg Ala Pro Ser 
    210                 215                 220                 


Val Thr Ser Ala Thr His Ser Gly Tyr Arg Leu Asn Asp Tyr Val 
225                 230                 235                 


<210>  3713
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  3713

Met Ala Phe Tyr Pro Leu Gln Ile Ala Gly Leu Val Leu Gly Phe Leu 
1               5                   10                  15      


Gly Met Val Gly Thr Leu Ala Thr Thr Leu Leu Pro Gln Trp Arg Val 
            20                  25                  30          


Ser Ala Phe Val Gly Ser Asn Ile Ile Val Phe Glu Arg Leu Trp Glu 
        35                  40                  45              


Gly Leu Trp Met Asn Cys Ile Arg Gln Ala Arg Val Arg Leu Gln Cys 
    50                  55                  60                  


Lys Phe Tyr Ser Ser Leu Leu Ala Leu Pro Pro Ala Leu Glu Thr Ala 
65                  70                  75                  80  


Arg Ala Leu Met Cys Val Ala Val Ala Leu Ser Leu Ile Ala Leu Leu 
                85                  90                  95      


Ile Gly Ile Cys Gly Met Lys Gln Val Gln Cys Thr Gly Ser Asn Glu 
            100                 105                 110         


Arg Ala Lys Ala Tyr Leu Leu Gly Thr Ser Gly Val Leu Phe Ile Leu 
        115                 120                 125             


Thr Gly Ile Phe Val Leu Ile Pro Val Ser Trp Thr Ala Asn Ile Ile 
    130                 135                 140                 


Ile Arg Asp Phe Tyr Asn Pro Ala Ile His Ile Gly Gln Lys Arg Glu 
145                 150                 155                 160 


Leu Gly Ala Ala Leu Phe Leu Gly Trp Ala Ser Ala Ala Val Leu Phe 
                165                 170                 175     


Ile Gly Gly Gly Leu Leu Cys Gly Phe Cys Cys Cys Asn Arg Lys Lys 
            180                 185                 190         


Gln Gly Tyr Arg Tyr Pro Val Pro Gly Tyr Arg Val Pro His Thr Asp 
        195                 200                 205             


Lys Arg Arg Asn Thr Thr Met Leu Ser Lys Thr Ser Thr Ser Tyr Val 
    210                 215                 220                 


<210>  3714
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  3714

Met Asn Glu Cys His Tyr Asp Lys His Met Asp Phe Phe Tyr Asn Arg 
1               5                   10                  15      


Ser Asn Thr Asp Thr Val Asp Asp Trp Thr Gly Thr Lys Leu Val Ile 
            20                  25                  30          


Val Leu Cys Val Gly Thr Phe Phe Cys Leu Phe Ile Phe Phe Ser Asn 
        35                  40                  45              


Ser Leu Val Ile Ala Ala Val Ile Lys Asn Arg Lys Phe His Phe Pro 
    50                  55                  60                  


Phe Tyr Tyr Leu Leu Ala Asn Leu Ala Ala Ala Asp Phe Phe Ala Gly 
65                  70                  75                  80  


Ile Ala Tyr Val Phe Leu Met Phe Asn Thr Gly Pro Val Ser Lys Thr 
                85                  90                  95      


Leu Thr Val Asn Arg Trp Phe Leu Arg Gln Gly Leu Leu Asp Ser Ser 
            100                 105                 110         


Leu Thr Ala Ser Leu Thr Asn Leu Leu Val Ile Ala Val Glu Arg His 
        115                 120                 125             


Met Ser Ile Met Arg Met Arg Val His Ser Asn Leu Thr Lys Lys Arg 
    130                 135                 140                 


Val Thr Leu Leu Ile Leu Leu Val Trp Ala Ile Ala Ile Phe Met Gly 
145                 150                 155                 160 


Ala Val Pro Thr Leu Gly Trp Asn Cys Leu Cys Asn Ile Ser Ala Cys 
                165                 170                 175     


Ser Ser Leu Ala Pro Ile Tyr Ser Arg Ser Tyr Leu Val Phe Trp Thr 
            180                 185                 190         


Val Ser Asn Leu Met Ala Phe Leu Ile Met Val Val Val Tyr Leu Arg 
        195                 200                 205             


Ile Tyr Val Tyr Val Lys Arg Lys Thr Asn Val Leu Ser Pro His Thr 
    210                 215                 220                 


Ser Gly Ser Ile Ser Arg Arg Arg Thr Pro Met Lys Leu Met Lys Thr 
225                 230                 235                 240 


Val Met Thr Val Leu Gly Ala Phe Val Val Cys Trp Thr Pro Gly Leu 
                245                 250                 255     


Val Val Leu Leu Leu Asp Gly Leu Asn Cys Arg Gln Cys Gly Val Gln 
            260                 265                 270         


His Val Lys Arg Trp Phe Leu Leu Leu Ala Leu Leu Asn Ser Val Val 
        275                 280                 285             


Asn Pro Ile Ile Tyr Ser Tyr Lys Asp Glu Asp Met Tyr Gly Thr Met 
    290                 295                 300                 


Lys Lys Met Ile Cys Cys Phe Ser Gln Glu Asn Pro Glu Arg Arg Pro 
305                 310                 315                 320 


Ser Arg Ile Pro Ser Thr Val Leu Ser Arg Ser Asp Thr Gly Ser Gln 
                325                 330                 335     


Tyr Ile Glu Asp Ser Ile Ser Gln Gly Ala Val Cys Asn Lys Ser Thr 
            340                 345                 350         


Ser 
    


<210>  3715
<211>  649
<212>  PRT
<213>  Homo sapiens

<400>  3715

Met Ser Ser Phe Gly Ala Gly Lys Thr Lys Glu Val Ile Phe Ser Val 
1               5                   10                  15      


Glu Asp Gly Ser Val Lys Met Phe Leu Arg Gly Arg Pro Val Pro Met 
            20                  25                  30          


Met Ile Pro Asp Glu Leu Ala Pro Thr Tyr Ser Leu Asp Thr Arg Ser 
        35                  40                  45              


Glu Leu Pro Ser Cys Arg Leu Lys Leu Glu Trp Val Tyr Gly Tyr Arg 
    50                  55                  60                  


Gly Arg Asp Cys Arg Ala Asn Leu Tyr Leu Leu Pro Thr Gly Glu Ile 
65                  70                  75                  80  


Val Tyr Phe Val Ala Ser Val Ala Val Leu Tyr Ser Val Glu Glu Gln 
                85                  90                  95      


Arg Gln Arg His Tyr Leu Gly His Asn Asp Asp Ile Lys Cys Leu Ala 
            100                 105                 110         


Ile His Pro Asp Met Val Thr Ile Ala Thr Gly Gln Val Ala Gly Thr 
        115                 120                 125             


Thr Lys Glu Gly Lys Pro Leu Pro Pro His Val Arg Ile Trp Asp Ser 
    130                 135                 140                 


Val Ser Leu Ser Thr Leu His Val Leu Gly Leu Gly Val Phe Asp Arg 
145                 150                 155                 160 


Ala Val Cys Cys Val Gly Phe Ser Lys Ser Asn Gly Gly Asn Leu Leu 
                165                 170                 175     


Cys Ala Val Asp Glu Ser Asn Asp His Met Leu Ser Val Trp Asp Trp 
            180                 185                 190         


Ala Lys Glu Thr Lys Val Val Asp Val Lys Cys Ser Asn Glu Ala Val 
        195                 200                 205             


Leu Val Ala Thr Phe His Pro Thr Asp Pro Thr Val Leu Ile Thr Cys 
    210                 215                 220                 


Gly Lys Ser His Ile Tyr Phe Trp Thr Leu Glu Gly Gly Ser Leu Ser 
225                 230                 235                 240 


Lys Arg Gln Gly Leu Phe Glu Lys His Glu Lys Pro Lys Tyr Val Leu 
                245                 250                 255     


Cys Val Thr Phe Leu Glu Gly Gly Asp Val Val Thr Gly Asp Ser Gly 
            260                 265                 270         


Gly Asn Leu Tyr Val Trp Gly Lys Gly Gly Asn Arg Ile Thr Gln Ala 
        275                 280                 285             


Val Leu Gly Ala His Asp Gly Gly Val Phe Gly Leu Cys Ala Leu Arg 
    290                 295                 300                 


Asp Gly Thr Leu Val Ser Gly Gly Gly Arg Asp Arg Arg Val Val Leu 
305                 310                 315                 320 


Trp Gly Ser Asp Tyr Ser Lys Leu Gln Glu Val Glu Val Pro Glu Asp 
                325                 330                 335     


Phe Gly Pro Val Arg Thr Val Ala Glu Gly His Gly Asp Thr Leu Tyr 
            340                 345                 350         


Val Gly Thr Thr Arg Asn Ser Ile Leu Gln Gly Ser Val His Thr Gly 
        355                 360                 365             


Phe Ser Leu Leu Val Gln Gly His Val Glu Glu Leu Trp Gly Leu Ala 
    370                 375                 380                 


Thr His Pro Ser Arg Ala Gln Phe Val Thr Cys Gly Gln Asp Lys Leu 
385                 390                 395                 400 


Val His Leu Trp Ser Ser Asp Ser His Gln Pro Leu Trp Ser Arg Ile 
                405                 410                 415     


Ile Glu Asp Pro Ala Arg Ser Ala Gly Phe His Pro Ser Gly Ser Val 
            420                 425                 430         


Leu Ala Val Gly Thr Val Thr Gly Arg Trp Leu Leu Leu Asp Thr Glu 
        435                 440                 445             


Thr His Asp Leu Val Ala Ile His Thr Asp Gly Asn Glu Gln Ile Ser 
    450                 455                 460                 


Val Val Ser Phe Ser Pro Asp Gly Ala Tyr Leu Ala Val Gly Ser His 
465                 470                 475                 480 


Asp Asn Leu Val Tyr Val Tyr Thr Val Asp Gln Gly Gly Arg Lys Val 
                485                 490                 495     


Ser Arg Leu Gly Lys Cys Ser Gly His Ser Ser Phe Ile Thr His Leu 
            500                 505                 510         


Asp Trp Ala Gln Asp Ser Ser Cys Phe Val Thr Asn Ser Gly Asp Tyr 
        515                 520                 525             


Glu Ile Leu Tyr Trp Asp Pro Ala Thr Cys Lys Gln Ile Thr Ser Ala 
    530                 535                 540                 


Asp Ala Val Arg Asn Met Glu Trp Ala Thr Ala Thr Cys Val Leu Gly 
545                 550                 555                 560 


Phe Gly Val Phe Gly Ile Trp Ser Glu Gly Ala Asp Gly Thr Asp Ile 
                565                 570                 575     


Asn Ala Val Ala Arg Ser His Asp Gly Lys Leu Leu Ala Ser Ala Asp 
            580                 585                 590         


Asp Phe Gly Lys Val His Leu Phe Ser Tyr Pro Cys Cys Gln Pro Arg 
        595                 600                 605             


Ala Leu Ser His Lys Tyr Gly Gly His Ser Ser His Val Thr Asn Val 
    610                 615                 620                 


Ala Phe Leu Trp Asp Asp Ser Met Ala Leu Thr Thr Gly Gly Lys Asp 
625                 630                 635                 640 


Thr Ser Val Leu Gln Trp Arg Val Val 
                645                 


<210>  3716
<211>  413
<212>  PRT
<213>  Homo sapiens

<400>  3716

Met Ala Ser Cys Ala Glu Pro Ser Glu Pro Ser Ala Pro Leu Pro Ala 
1               5                   10                  15      


Gly Val Pro Pro Leu Glu Asp Phe Glu Val Leu Asp Gly Val Glu Asp 
            20                  25                  30          


Ala Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Asp 
        35                  40                  45              


Leu Ser Glu Leu Pro Pro Leu Glu Asp Met Gly Gln Pro Pro Ala Glu 
    50                  55                  60                  


Glu Ala Glu Gln Pro Gly Ala Leu Ala Arg Glu Phe Leu Ala Ala Met 
65                  70                  75                  80  


Glu Pro Glu Pro Ala Pro Ala Pro Ala Pro Glu Glu Trp Leu Asp Ile 
                85                  90                  95      


Leu Gly Asn Gly Leu Leu Arg Lys Lys Thr Leu Val Pro Gly Pro Pro 
            100                 105                 110         


Gly Ser Ser Arg Pro Val Lys Gly Gln Val Val Thr Val His Leu Gln 
        115                 120                 125             


Thr Ser Leu Glu Asn Gly Thr Arg Val Gln Glu Glu Pro Glu Leu Val 
    130                 135                 140                 


Phe Thr Leu Gly Asp Cys Asp Val Ile Gln Ala Leu Asp Leu Ser Val 
145                 150                 155                 160 


Pro Leu Met Asp Val Gly Glu Thr Ala Met Val Thr Ala Asp Ser Lys 
                165                 170                 175     


Tyr Cys Tyr Gly Pro Gln Gly Ser Arg Ser Pro Tyr Ile Pro Pro His 
            180                 185                 190         


Ala Ala Leu Cys Leu Glu Val Thr Leu Lys Thr Ala Val Asp Gly Pro 
        195                 200                 205             


Asp Leu Glu Met Leu Thr Gly Gln Glu Arg Val Ala Leu Ala Asn Arg 
    210                 215                 220                 


Lys Arg Glu Cys Gly Asn Ala His Tyr Gln Arg Ala Asp Phe Val Leu 
225                 230                 235                 240 


Ala Ala Asn Ser Tyr Asp Leu Ala Ile Lys Ala Ile Thr Ser Ser Ala 
                245                 250                 255     


Lys Val Asp Met Thr Phe Glu Glu Glu Ala Gln Leu Leu Gln Leu Lys 
            260                 265                 270         


Val Lys Cys Leu Asn Asn Leu Ala Ala Ser Gln Leu Lys Leu Asp His 
        275                 280                 285             


Tyr Arg Ala Ala Leu Arg Ser Cys Ser Leu Val Leu Glu His Gln Pro 
    290                 295                 300                 


Asp Asn Ile Lys Ala Leu Phe Arg Lys Gly Lys Val Leu Ala Gln Gln 
305                 310                 315                 320 


Gly Glu Tyr Ser Glu Ala Ile Pro Ile Leu Arg Ala Ala Leu Lys Leu 
                325                 330                 335     


Glu Pro Ser Asn Lys Thr Ile His Ala Glu Leu Ser Lys Leu Val Lys 
            340                 345                 350         


Lys His Ala Ala Gln Arg Ser Thr Glu Thr Ala Leu Tyr Arg Lys Met 
        355                 360                 365             


Leu Gly Asn Pro Ser Arg Leu Pro Ala Lys Cys Pro Gly Lys Gly Ala 
    370                 375                 380                 


Trp Ser Ile Pro Trp Lys Trp Leu Phe Gly Ala Thr Ala Val Ala Leu 
385                 390                 395                 400 


Gly Gly Val Ala Leu Ser Val Val Ile Ala Ala Arg Asn 
                405                 410             


<210>  3717
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  3717

Met Ala Trp Arg Gly Ala Gly Pro Ser Val Pro Gly Ala Pro Gly Gly 
1               5                   10                  15      


Val Gly Leu Ser Leu Gly Leu Leu Leu Gln Leu Leu Leu Leu Leu Gly 
            20                  25                  30          


Pro Ala Arg Gly Phe Gly Asp Glu Glu Glu Arg Arg Cys Asp Pro Ile 
        35                  40                  45              


Arg Ile Ser Met Cys Gln Asn Leu Gly Tyr Asn Val Thr Lys Met Pro 
    50                  55                  60                  


Asn Leu Val Gly His Glu Leu Gln Thr Asp Ala Glu Leu Gln Leu Thr 
65                  70                  75                  80  


Thr Phe Thr Pro Leu Ile Gln Tyr Gly Cys Ser Ser Gln Leu Gln Phe 
                85                  90                  95      


Phe Leu Cys Ser Val Tyr Val Pro Met Cys Thr Glu Lys Ile Asn Ile 
            100                 105                 110         


Pro Ile Gly Pro Cys Gly Gly Met Cys Leu Ser Val Lys Arg Arg Cys 
        115                 120                 125             


Glu Pro Val Leu Lys Glu Phe Gly Phe Ala Trp Pro Glu Ser Leu Asn 
    130                 135                 140                 


Cys Ser Lys Phe Pro Pro Gln Asn Asp His Asn His Met Cys Met Glu 
145                 150                 155                 160 


Gly Pro Gly Asp Glu Glu Val Pro Leu Pro His Lys Thr Pro Ile Gln 
                165                 170                 175     


Pro Gly Glu Glu Cys His Ser Val Gly Thr Asn Ser Asp Gln Tyr Ile 
            180                 185                 190         


Trp Val Lys Arg Ser Leu Asn Cys Val Leu Lys Cys Gly Tyr Asp Ala 
        195                 200                 205             


Gly Leu Tyr Ser Arg Ser Ala Lys Glu Phe Thr Asp Ile Trp Met Ala 
    210                 215                 220                 


Val Trp Ala Ser Leu Cys Phe Ile Ser Thr Ala Phe Thr Val Leu Thr 
225                 230                 235                 240 


Phe Leu Ile Asp Ser Ser Arg Phe Ser Tyr Pro Glu Arg Pro Ile Ile 
                245                 250                 255     


Phe Leu Ser Met Cys Tyr Asn Ile Tyr Ser Ile Ala Tyr Ile Val Arg 
            260                 265                 270         


Leu Thr Val Gly Arg Glu Arg Ile Ser Cys Asp Phe Glu Glu Ala Ala 
        275                 280                 285             


Glu Pro Val Leu Ile Gln Glu Gly Leu Lys Asn Thr Gly Cys Ala Ile 
    290                 295                 300                 


Ile Phe Leu Leu Met Tyr Phe Phe Gly Met Ala Ser Ser Ile Trp Trp 
305                 310                 315                 320 


Val Ile Leu Thr Leu Thr Trp Phe Leu Ala Ala Gly Leu Lys Trp Gly 
                325                 330                 335     


His Glu Ala Ile Glu Met His Ser Ser Tyr Phe His Ile Ala Ala Trp 
            340                 345                 350         


Ala Ile Pro Ala Val Lys Thr Ile Val Ile Leu Ile Met Arg Leu Val 
        355                 360                 365             


Asp Ala Asp Glu Leu Thr Gly Leu Cys Tyr Val Gly Asn Gln Asn Leu 
    370                 375                 380                 


Asp Ala Leu Thr Gly Phe Val Val Ala Pro Leu Phe Thr Tyr Leu Val 
385                 390                 395                 400 


Ile Gly Thr Leu Phe Ile Ala Ala Gly Leu Val Ala Leu Phe Lys Ile 
                405                 410                 415     


Arg Ser Asn Leu Gln Lys Asp Gly Thr Lys Thr Asp Lys Leu Glu Arg 
            420                 425                 430         


Leu Met Val Lys Ile Gly Val Phe Ser Val Leu Tyr Thr Val Pro Ala 
        435                 440                 445             


Thr Cys Val Ile Ala Cys Tyr Phe Tyr Glu Ile Ser Asn Trp Ala Leu 
    450                 455                 460                 


Phe Arg Tyr Ser Ala Asp Asp Ser Asn Met Ala Val Glu Met Leu Lys 
465                 470                 475                 480 


Ile Phe Met Ser Leu Leu Val Gly Ile Thr Ser Gly Met Trp Ile Trp 
                485                 490                 495     


Ser Ala Lys Thr Leu His Thr Trp Gln Lys Cys Ser Asn Arg Leu Val 
            500                 505                 510         


Asn Ser Gly Lys Val Lys Arg Glu Lys Arg Gly Asn Gly Trp Val Lys 
        515                 520                 525             


Pro Gly Lys Gly Ser Glu Thr Val Val 
    530                 535         


<210>  3718
<211>  1849
<212>  PRT
<213>  Homo sapiens

<400>  3718

Met Asp His Thr Ala Ser Gln Asn Ala Gln Asp Leu Ile Gly Ile Pro 
1               5                   10                  15      


His Leu Gly Val Ser Gly Ser Ser Thr Lys Trp His Ser Glu Leu Ser 
            20                  25                  30          


Pro Thr Glu Gly Pro His Ser Ala Gly Ser Ser Thr Pro Gly Phe Leu 
        35                  40                  45              


Ser Pro Met Ala Glu Leu Ser His Pro Ser Pro Pro Pro Pro Ala Leu 
    50                  55                  60                  


Gly Ser Leu Leu Gln Leu Pro Asp Gly Ser Pro Ser Trp Ser Met Leu 
65                  70                  75                  80  


Glu Val Ala Ser Gly Pro Ala Ser Thr Gln Gln Ile Lys Ala Gly Val 
                85                  90                  95      


Pro Gly Arg Val His Asn Gly Val Ser Leu Pro Thr Phe Lys Asn Thr 
            100                 105                 110         


Glu Thr Ala Thr His Glu Ala Glu Pro Pro Leu Phe Gln Thr Ala Glu 
        115                 120                 125             


Ser Gly Ala Ile Glu Met Thr Ser Arg Lys Leu Ala Ser Ala Thr Ala 
    130                 135                 140                 


Asn Asp Ser Ala Asn Pro Leu His Leu Ser Ala Ala Pro Glu Asn Ser 
145                 150                 155                 160 


Arg Gly Pro Ala Leu Ser Ala Glu His Thr Ser Ser Leu Val Pro Ser 
                165                 170                 175     


Leu His Ile Thr Thr Leu Gly Gln Glu Gln Ala Ile Leu Ser Gly Ala 
            180                 185                 190         


Val Pro Ala Ser Pro Ser Thr Gly Thr Ala Asp Phe Pro Ser Ile Leu 
        195                 200                 205             


Thr Phe Leu Gln Pro Thr Glu Asn His Ala Ser Pro Ser Pro Val Pro 
    210                 215                 220                 


Glu Met Pro Thr Leu Pro Ala Glu Gly Ser Asp Gly Ser Pro Pro Ala 
225                 230                 235                 240 


Thr Arg Asp Leu Leu Leu Ser Ser Lys Val Pro Asn Leu Leu Ser Thr 
                245                 250                 255     


Ser Trp Thr Phe Pro Arg Trp Lys Lys Asp Ser Val Thr Ala Ile Leu 
            260                 265                 270         


Gly Lys Asn Glu Glu Ala Asn Val Thr Ile Pro Leu Gln Ala Phe Pro 
        275                 280                 285             


Arg Lys Glu Val Leu Ser Leu His Thr Val Asn Gly Phe Val Ser Asp 
    290                 295                 300                 


Phe Ser Thr Gly Ser Val Ser Ser Pro Ile Ile Thr Ala Pro Arg Thr 
305                 310                 315                 320 


Asn Pro Leu Pro Ser Gly Pro Pro Leu Pro Ser Ile Leu Ser Ile Gln 
                325                 330                 335     


Ala Thr Gln Thr Val Phe Pro Ser Leu Gly Phe Ser Ser Thr Lys Pro 
            340                 345                 350         


Glu Ala Tyr Ala Ala Ala Val Asp His Ser Gly Leu Pro Ala Ser Ala 
        355                 360                 365             


Ser Lys Gln Val Arg Ala Ser Pro Ser Ser Met Asp Val Tyr Asp Ser 
    370                 375                 380                 


Leu Thr Ile Gly Asp Met Lys Lys Pro Ala Thr Thr Asp Val Phe Trp 
385                 390                 395                 400 


Ser Ser Leu Ser Ala Glu Thr Gly Ser Leu Ser Thr Glu Ser Ile Ile 
                405                 410                 415     


Ser Gly Leu Gln Gln Gln Thr Asn Tyr Asp Leu Asn Gly His Thr Ile 
            420                 425                 430         


Ser Thr Thr Ser Trp Glu Thr His Leu Ala Pro Thr Ala Pro Pro Asn 
        435                 440                 445             


Gly Leu Thr Ser Ala Ala Asp Ala Ile Lys Ser Gln Asp Phe Lys Asp 
    450                 455                 460                 


Thr Ala Gly His Ser Val Thr Ala Glu Gly Phe Ser Ile Gln Asp Leu 
465                 470                 475                 480 


Val Leu Gly Thr Ser Ile Glu Gln Pro Val Gln Gln Ser Asp Met Thr 
                485                 490                 495     


Met Val Gly Ser His Ile Asp Leu Trp Pro Thr Ser Asn Asn Asn His 
            500                 505                 510         


Ser Arg Asp Phe Gln Thr Ala Glu Val Ala Tyr Tyr Ser Pro Thr Thr 
        515                 520                 525             


Arg His Ser Val Ser His Pro Gln Leu Gln Leu Pro Asn Gln Pro Ala 
    530                 535                 540                 


His Pro Leu Leu Leu Thr Ser Pro Gly Pro Thr Ser Thr Gly Ser Leu 
545                 550                 555                 560 


Gln Glu Met Leu Ser Asp Gly Thr Asp Thr Gly Ser Glu Ile Ser Ser 
                565                 570                 575     


Asp Ile Asn Ser Ser Pro Glu Arg Asn Ala Ser Thr Pro Phe Gln Asn 
            580                 585                 590         


Ile Leu Gly Tyr His Ser Ala Ala Glu Ser Ser Ile Ser Thr Ser Val 
        595                 600                 605             


Phe Pro Arg Thr Ser Ser Arg Val Leu Arg Ala Ser Gln His Pro Lys 
    610                 615                 620                 


Lys Trp Thr Ala Asp Thr Val Ser Ser Lys Val Gln Pro Thr Ala Ala 
625                 630                 635                 640 


Ala Ala Val Thr Leu Phe Leu Arg Lys Ser Ser Pro Pro Ala Leu Ser 
                645                 650                 655     


Ala Ala Leu Val Ala Lys Gly Thr Ser Ser Ser Pro Leu Ala Val Ala 
            660                 665                 670         


Ser Gly Pro Ala Lys Ser Ser Ser Met Thr Thr Leu Ala Lys Asn Val 
        675                 680                 685             


Thr Asn Lys Ala Ala Ser Gly Pro Lys Arg Thr Pro Gly Ala Val His 
    690                 695                 700                 


Thr Ala Phe Pro Phe Thr Pro Thr Tyr Met Tyr Ala Arg Thr Gly His 
705                 710                 715                 720 


Thr Thr Ser Thr His Thr Ala Met Gln Gly Asn Met Asp Thr Ala Ser 
                725                 730                 735     


Gly Leu Leu Ser Thr Thr Tyr Leu Pro Arg Lys Pro Gln Ala Met His 
            740                 745                 750         


Thr Gly Leu Pro Asn Pro Thr Asn Leu Glu Met Pro Arg Ala Ser Thr 
        755                 760                 765             


Pro Arg Pro Leu Thr Val Thr Ala Ala Leu Thr Ser Ile Thr Ala Ser 
    770                 775                 780                 


Val Lys Ala Thr Arg Leu Pro Pro Leu Arg Ala Glu Asn Thr Asp Ala 
785                 790                 795                 800 


Val Leu Pro Ala Ala Ser Ala Ala Val Val Thr Thr Gly Lys Met Ala 
                805                 810                 815     


Ser Asn Leu Glu Cys Gln Met Ser Ser Lys Leu Leu Val Lys Thr Val 
            820                 825                 830         


Leu Phe Leu Thr Gln Arg Arg Val Gln Ile Ser Glu Ser Leu Lys Phe 
        835                 840                 845             


Ser Ile Ala Lys Gly Leu Thr Gln Ala Leu Arg Lys Ala Phe His Gln 
    850                 855                 860                 


Asn Asp Val Ser Ala His Val Asp Ile Leu Glu Tyr Ser His Asn Val 
865                 870                 875                 880 


Thr Val Gly Tyr Tyr Ala Thr Lys Gly Lys Leu Val Tyr Leu Pro Ala 
                885                 890                 895     


Val Val Ile Glu Met Leu Gly Val Tyr Gly Val Ser Asn Val Thr Ala 
            900                 905                 910         


Asp Leu Lys Gln His Thr Pro His Leu Gln Ser Val Ala Val Leu Ala 
        915                 920                 925             


Ser Pro Trp Asn Pro Gln Pro Ala Gly Tyr Phe Gln Leu Lys Thr Val 
    930                 935                 940                 


Leu Gln Phe Val Ser Gln Ala Asp Asn Ile Gln Ser Cys Lys Phe Ala 
945                 950                 955                 960 


Gln Thr Met Glu Gln Arg Leu Gln Lys Ala Phe Gln Asp Ala Glu Arg 
                965                 970                 975     


Lys Val Leu Asn Thr Lys Ser Asn Leu Thr Ile Gln Ile Val Ser Thr 
            980                 985                 990         


Ser Asn Ala Ser Gln Ala Val Thr  Leu Val Tyr Val Val  Gly Asn Gln 
        995                 1000                 1005             


Ser Thr  Phe Leu Asn Gly Thr  Val Ala Ser Ser Leu  Leu Ser Gln 
    1010                 1015                 1020             


Leu Ser  Ala Glu Leu Val Gly  Phe Tyr Leu Thr Tyr  Pro Pro Leu 
    1025                 1030                 1035             


Thr Ile  Ala Glu Pro Leu Glu  Tyr Pro Asn Leu Asp  Ile Ser Glu 
    1040                 1045                 1050             


Thr Thr  Arg Asp Tyr Trp Val  Ile Thr Val Leu Gln  Gly Val Asp 
    1055                 1060                 1065             


Asn Ser  Leu Val Gly Leu His  Asn Gln Ser Phe Ala  Arg Val Met 
    1070                 1075                 1080             


Glu Gln  Arg Leu Ala Gln Leu  Phe Met Met Ser Gln  Gln Gln Gly 
    1085                 1090                 1095             


Arg Arg  Phe Lys Arg Ala Thr  Thr Leu Gly Ser Tyr  Thr Val Gln 
    1100                 1105                 1110             


Met Val  Lys Met Gln Arg Val  Pro Gly Pro Lys Asp  Pro Ala Glu 
    1115                 1120                 1125             


Leu Thr  Tyr Tyr Thr Leu Tyr  Asn Gly Lys Pro Leu  Leu Gly Thr 
    1130                 1135                 1140             


Ala Ala  Ala Lys Ile Leu Ser  Thr Ile Asp Ser Gln  Arg Met Ala 
    1145                 1150                 1155             


Leu Thr  Leu His His Val Val  Leu Leu Gln Ala Asp  Pro Val Val 
    1160                 1165                 1170             


Lys Asn  Pro Pro Asn Asn Leu  Trp Ile Ile Ala Ala  Val Leu Ala 
    1175                 1180                 1185             


Pro Ile  Ala Val Val Thr Val  Ile Ile Ile Ile Ile  Thr Ala Val 
    1190                 1195                 1200             


Leu Cys  Arg Lys Asn Lys Asn  Asp Phe Lys Pro Asp  Thr Met Ile 
    1205                 1210                 1215             


Asn Leu  Pro Gln Arg Ala Lys  Pro Val Gln Gly Phe  Asp Tyr Ala 
    1220                 1225                 1230             


Lys Gln  His Leu Gly Gln Gln  Gly Ala Asp Glu Glu  Val Ile Pro 
    1235                 1240                 1245             


Val Thr  Gln Glu Thr Val Val  Leu Pro Leu Pro Ile  Arg Asp Ala 
    1250                 1255                 1260             


Pro Gln  Glu Arg Asp Val Ala  Gln Asp Gly Ser Thr  Ile Lys Thr 
    1265                 1270                 1275             


Ala Lys  Ser Thr Glu Thr Arg  Lys Ser Arg Ser Pro  Ser Glu Asn 
    1280                 1285                 1290             


Gly Ser  Val Ile Ser Asn Glu  Ser Gly Lys Pro Ser  Ser Gly Arg 
    1295                 1300                 1305             


Arg Ser  Pro Gln Asn Val Met  Ala Gln Gln Lys Val  Thr Lys Glu 
    1310                 1315                 1320             


Glu Ala  Arg Lys Arg Asn Val  Pro Ala Ser Asp Glu  Glu Glu Gly 
    1325                 1330                 1335             


Ala Val  Leu Phe Asp Asn Ser  Ser Lys Val Ala Ala  Glu Pro Phe 
    1340                 1345                 1350             


Asp Thr  Ser Ser Gly Ser Val  Gln Leu Ile Ala Ile  Lys Pro Thr 
    1355                 1360                 1365             


Ala Leu  Pro Met Val Pro Pro  Thr Ser Asp Arg Ser  Gln Glu Ser 
    1370                 1375                 1380             


Ser Ala  Val Leu Asn Gly Glu  Val Asn Lys Ala Leu  Lys Gln Lys 
    1385                 1390                 1395             


Ser Asp  Ile Glu His Tyr Arg  Asn Lys Leu Arg Leu  Lys Ala Lys 
    1400                 1405                 1410             


Arg Lys  Gly Tyr Tyr Asp Phe  Pro Ala Val Glu Thr  Ser Lys Gly 
    1415                 1420                 1425             


Leu Thr  Glu Arg Lys Lys Met  Tyr Glu Lys Ala Pro  Lys Glu Met 
    1430                 1435                 1440             


Glu His  Val Leu Asp Pro Asp  Ser Glu Leu Cys Ala  Pro Phe Thr 
    1445                 1450                 1455             


Glu Ser  Lys Asn Arg Gln Gln  Met Lys Asn Ser Val  Tyr Arg Ser 
    1460                 1465                 1470             


Arg Gln  Ser Leu Asn Ser Pro  Ser Pro Gly Glu Thr  Glu Met Asp 
    1475                 1480                 1485             


Leu Leu  Val Thr Arg Glu Arg  Pro Arg Arg Gly Ile  Arg Asn Ser 
    1490                 1495                 1500             


Gly Tyr  Asp Thr Glu Pro Glu  Ile Ile Glu Glu Thr  Asn Ile Asp 
    1505                 1510                 1515             


Arg Val  Pro Glu Pro Arg Gly  Tyr Ser Arg Ser Arg  Gln Val Lys 
    1520                 1525                 1530             


Gly His  Ser Glu Thr Ser Thr  Leu Ser Ser Gln Pro  Ser Ile Asp 
    1535                 1540                 1545             


Glu Val  Arg Gln Gln Met His  Met Leu Leu Glu Glu  Ala Phe Ser 
    1550                 1555                 1560             


Leu Ala  Ser Ala Gly His Ala  Gly Gln Ser Arg His  Gln Glu Ala 
    1565                 1570                 1575             


Tyr Gly  Ser Ala Gln His Leu  Pro Tyr Ser Glu Val  Val Thr Ser 
    1580                 1585                 1590             


Ala Pro  Gly Thr Met Thr Arg  Pro Arg Ala Gly Val  Gln Trp Val 
    1595                 1600                 1605             


Pro Thr  Tyr Arg Pro Glu Met  Tyr Gln Tyr Ser Leu  Pro Arg Pro 
    1610                 1615                 1620             


Ala Tyr  Arg Phe Ser Gln Leu  Pro Glu Met Val Met  Gly Ser Pro 
    1625                 1630                 1635             


Pro Pro  Pro Val Pro Pro Arg  Thr Gly Pro Val Ala  Val Ala Ser 
    1640                 1645                 1650             


Leu Arg  Arg Ser Thr Ser Asp  Ile Gly Ser Lys Thr  Arg Met Ala 
    1655                 1660                 1665             


Glu Ser  Thr Gly Pro Glu Pro  Ala Gln Leu His Asp  Ser Ala Ser 
    1670                 1675                 1680             


Phe Thr  Gln Met Ser Arg Gly  Pro Val Ser Val Thr  Gln Leu Asp 
    1685                 1690                 1695             


Gln Ser  Ala Leu Asn Tyr Ser  Gly Asn Thr Val Pro  Ala Val Phe 
    1700                 1705                 1710             


Ala Ile  Pro Ala Ala Asn Arg  Pro Gly Phe Thr Gly  Tyr Phe Ile 
    1715                 1720                 1725             


Pro Thr  Pro Pro Ser Ser Tyr  Arg Asn Gln Ala Trp  Met Ser Tyr 
    1730                 1735                 1740             


Ala Gly  Glu Asn Glu Leu Pro  Ser Gln Trp Ala Asp  Ser Val Pro 
    1745                 1750                 1755             


Leu Pro  Gly Tyr Ile Glu Ala  Tyr Pro Arg Ser Arg  Tyr Pro Gln 
    1760                 1765                 1770             


Ser Ser  Pro Ser Arg Leu Pro  Arg Gln Tyr Ser Gln  Pro Ala Asn 
    1775                 1780                 1785             


Leu His  Pro Ser Leu Glu Gln  Ala Pro Ala Pro Ser  Thr Ala Ala 
    1790                 1795                 1800             


Ser Gln  Gln Ser Leu Ala Glu  Asn Asp Pro Ser Asp  Ala Pro Leu 
    1805                 1810                 1815             


Thr Asn  Ile Ser Thr Ala Ala  Leu Val Lys Ala Ile  Arg Glu Glu 
    1820                 1825                 1830             


Val Ala  Lys Leu Ala Lys Lys  Gln Thr Asp Met Phe  Glu Phe Gln 
    1835                 1840                 1845             


Val 
    


<210>  3719
<211>  1069
<212>  PRT
<213>  Homo sapiens

<400>  3719

Met Asp Asp Lys Ala Ser Val Gly Lys Ile Ser Val Ser Ser Asp Ser 
1               5                   10                  15      


Val Ser Thr Leu Asn Ser Glu Asp Phe Val Leu Val Ser Arg Gln Gly 
            20                  25                  30          


Asp Glu Thr Pro Ser Thr Asn Asn Gly Ser Asp Asp Glu Lys Thr Gly 
        35                  40                  45              


Leu Lys Ile Val Gly Asn Gly Ser Glu Gln Gln Leu Gln Lys Glu Leu 
    50                  55                  60                  


Ala Asp Val Leu Met Asp Pro Pro Met Asp Asp Gln Pro Gly Glu Lys 
65                  70                  75                  80  


Glu Leu Val Lys Arg Ser Gln Leu Asp Gly Glu Gly Asp Gly Pro Leu 
                85                  90                  95      


Ser Asn Gln Leu Ser Ala Ser Ser Thr Ile Asn Pro Val Pro Leu Val 
            100                 105                 110         


Gly Leu Gln Lys Pro Glu Met Ser Leu Pro Val Lys Pro Gly Gln Gly 
        115                 120                 125             


Asp Ser Glu Ala Ser Ser Pro Phe Thr Pro Val Ala Asp Glu Asp Ser 
    130                 135                 140                 


Val Val Phe Ser Lys Leu Thr Tyr Leu Gly Cys Ala Ser Val Asn Ala 
145                 150                 155                 160 


Pro Arg Ser Glu Val Glu Ala Leu Arg Met Met Ser Ile Leu Arg Ser 
                165                 170                 175     


Gln Cys Gln Ile Ser Leu Asp Val Thr Leu Ser Val Pro Asn Val Ser 
            180                 185                 190         


Glu Gly Ile Val Arg Leu Leu Asp Pro Gln Thr Asn Thr Glu Ile Ala 
        195                 200                 205             


Asn Tyr Pro Ile Tyr Lys Ile Leu Phe Cys Val Arg Gly His Asp Gly 
    210                 215                 220                 


Thr Pro Glu Ser Asp Cys Phe Ala Phe Thr Glu Ser His Tyr Asn Ala 
225                 230                 235                 240 


Glu Leu Phe Arg Ile His Val Phe Arg Cys Glu Ile Gln Glu Ala Val 
                245                 250                 255     


Ser Arg Ile Leu Tyr Ser Phe Ala Thr Ala Phe Arg Arg Ser Ala Lys 
            260                 265                 270         


Gln Thr Pro Leu Ser Ala Thr Ala Ala Pro Gln Thr Pro Asp Ser Asp 
        275                 280                 285             


Ile Phe Thr Phe Ser Val Ser Leu Glu Ile Lys Glu Asp Asp Gly Lys 
    290                 295                 300                 


Gly Tyr Phe Ser Ala Val Pro Lys Asp Lys Asp Arg Gln Cys Phe Lys 
305                 310                 315                 320 


Leu Arg Gln Gly Ile Asp Lys Lys Ile Val Ile Tyr Val Gln Gln Thr 
                325                 330                 335     


Thr Asn Lys Glu Leu Ala Ile Glu Arg Cys Phe Gly Leu Leu Leu Ser 
            340                 345                 350         


Pro Gly Lys Asp Val Arg Asn Ser Asp Met His Leu Leu Asp Leu Glu 
        355                 360                 365             


Ser Met Gly Lys Ser Ser Asp Gly Lys Ser Tyr Val Ile Thr Gly Ser 
    370                 375                 380                 


Trp Asn Pro Lys Ser Pro His Phe Gln Val Val Asn Glu Glu Thr Pro 
385                 390                 395                 400 


Lys Asp Lys Val Leu Phe Met Thr Thr Ala Val Asp Leu Val Ile Thr 
                405                 410                 415     


Glu Val Gln Glu Pro Val Arg Phe Leu Leu Glu Thr Lys Val Arg Val 
            420                 425                 430         


Cys Ser Pro Asn Glu Arg Leu Phe Trp Pro Phe Ser Lys Arg Ser Thr 
        435                 440                 445             


Thr Glu Asn Phe Phe Leu Lys Leu Lys Gln Ile Lys Gln Arg Glu Arg 
    450                 455                 460                 


Lys Asn Asn Thr Asp Thr Leu Tyr Glu Val Val Cys Leu Glu Ser Glu 
465                 470                 475                 480 


Ser Glu Arg Glu Arg Arg Lys Thr Thr Ala Ser Pro Ser Val Arg Leu 
                485                 490                 495     


Pro Gln Ser Gly Ser Gln Ser Ser Val Ile Pro Ser Pro Pro Glu Asp 
            500                 505                 510         


Asp Glu Glu Glu Asp Asn Asp Glu Pro Leu Leu Ser Gly Ser Gly Asp 
        515                 520                 525             


Val Ser Lys Glu Cys Ala Glu Lys Ile Leu Glu Thr Trp Gly Glu Leu 
    530                 535                 540                 


Leu Ser Lys Trp His Leu Asn Leu Asn Val Arg Pro Lys Gln Leu Ser 
545                 550                 555                 560 


Ser Leu Val Arg Asn Gly Val Pro Glu Ala Leu Arg Gly Glu Val Trp 
                565                 570                 575     


Gln Leu Leu Ala Gly Cys His Asn Asn Asp His Leu Val Glu Lys Tyr 
            580                 585                 590         


Arg Ile Leu Ile Thr Lys Glu Ser Pro Gln Asp Ser Ala Ile Thr Arg 
        595                 600                 605             


Asp Ile Asn Arg Thr Phe Pro Ala His Asp Tyr Phe Lys Asp Thr Gly 
    610                 615                 620                 


Gly Asp Gly Gln Asp Ser Leu Tyr Lys Ile Cys Lys Ala Tyr Ser Val 
625                 630                 635                 640 


Tyr Asp Glu Glu Ile Gly Tyr Cys Gln Gly Gln Ser Phe Leu Ala Ala 
                645                 650                 655     


Val Leu Leu Leu His Met Pro Glu Glu Gln Ala Phe Ser Val Leu Val 
            660                 665                 670         


Lys Ile Met Phe Asp Tyr Gly Leu Arg Glu Leu Phe Lys Gln Asn Phe 
        675                 680                 685             


Glu Asp Leu His Cys Lys Phe Tyr Gln Leu Glu Arg Leu Met Gln Glu 
    690                 695                 700                 


Tyr Ile Pro Asp Leu Tyr Asn His Phe Leu Asp Ile Ser Leu Glu Ala 
705                 710                 715                 720 


His Met Tyr Ala Ser Gln Trp Phe Leu Thr Leu Phe Thr Ala Lys Phe 
                725                 730                 735     


Pro Leu Tyr Met Val Phe His Ile Ile Asp Leu Leu Leu Cys Glu Gly 
            740                 745                 750         


Ile Ser Val Ile Phe Asn Val Ala Leu Gly Leu Leu Lys Thr Ser Lys 
        755                 760                 765             


Asp Asp Leu Leu Leu Thr Asp Phe Glu Gly Ala Leu Lys Phe Phe Arg 
    770                 775                 780                 


Val Gln Leu Pro Lys Arg Tyr Arg Ser Glu Glu Asn Ala Lys Lys Leu 
785                 790                 795                 800 


Met Glu Leu Ala Cys Asn Met Lys Ile Ser Gln Lys Lys Leu Lys Lys 
                805                 810                 815     


Tyr Glu Lys Glu Tyr His Thr Met Arg Glu Gln Gln Ala Gln Gln Glu 
            820                 825                 830         


Asp Pro Ile Glu Arg Phe Glu Arg Glu Asn Arg Arg Leu Gln Glu Ala 
        835                 840                 845             


Asn Met Arg Leu Glu Gln Glu Asn Asp Asp Leu Ala His Glu Leu Val 
    850                 855                 860                 


Thr Ser Lys Ile Ala Leu Arg Lys Asp Leu Asp Asn Ala Glu Glu Lys 
865                 870                 875                 880 


Ala Asp Ala Leu Asn Lys Glu Leu Leu Met Thr Lys Gln Lys Leu Ile 
                885                 890                 895     


Asp Ala Glu Glu Glu Lys Arg Arg Leu Glu Glu Glu Ser Ala Gln Leu 
            900                 905                 910         


Lys Glu Met Cys Arg Arg Glu Leu Asp Lys Ala Glu Ser Glu Ile Lys 
        915                 920                 925             


Lys Asn Ser Ser Ile Ile Gly Asp Tyr Lys Gln Ile Cys Ser Gln Leu 
    930                 935                 940                 


Ser Glu Arg Leu Glu Lys Gln Gln Thr Ala Asn Lys Val Glu Ile Glu 
945                 950                 955                 960 


Lys Ile Arg Gln Lys Val Asp Asp Cys Glu Arg Cys Arg Glu Phe Phe 
                965                 970                 975     


Asn Lys Glu Gly Arg Val Lys Gly Ile Ser Ser Thr Lys Glu Val Leu 
            980                 985                 990         


Asp Glu Asp Thr Asp Glu Glu Lys  Glu Thr Leu Lys Asn  Gln Leu Arg 
        995                 1000                 1005             


Glu Met  Glu Leu Glu Leu Ala  Gln Thr Lys Leu Gln  Leu Val Glu 
    1010                 1015                 1020             


Ala Glu  Cys Lys Ile Gln Asp  Leu Glu His His Leu  Gly Leu Ala 
    1025                 1030                 1035             


Leu Asn  Glu Val Gln Ala Ala  Lys Lys Thr Trp Phe  Asn Arg Thr 
    1040                 1045                 1050             


Leu Ser  Ser Ile Lys Thr Ala  Thr Gly Val Gln Gly  Lys Glu Thr 
    1055                 1060                 1065             


Cys 
    


<210>  3720
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  3720

Met Lys Leu Lys Leu Lys Asn Val Phe Leu Ala Tyr Phe Leu Val Ser 
1               5                   10                  15      


Ile Ala Gly Leu Leu Tyr Ala Leu Val Gln Leu Gly Gln Pro Cys Asp 
            20                  25                  30          


Cys Leu Pro Pro Leu Arg Ala Ala Ala Glu Gln Leu Arg Gln Lys Asp 
        35                  40                  45              


Leu Arg Ile Ser Gln Leu Gln Ala Glu Leu Arg Arg Pro Pro Pro Ala 
    50                  55                  60                  


Pro Ala Gln Pro Pro Glu Pro Glu Ala Leu Pro Thr Ile Tyr Val Val 
65                  70                  75                  80  


Thr Pro Thr Tyr Ala Arg Leu Val Gln Lys Ala Glu Leu Val Arg Leu 
                85                  90                  95      


Ser Gln Thr Leu Ser Leu Val Pro Arg Leu His Trp Leu Leu Val Glu 
            100                 105                 110         


Asp Ala Glu Gly Pro Thr Pro Leu Val Ser Gly Leu Leu Ala Ala Ser 
        115                 120                 125             


Gly Leu Leu Phe Thr His Leu Val Val Leu Thr Pro Lys Ala Gln Arg 
    130                 135                 140                 


Leu Arg Glu Gly Glu Pro Gly Trp Val His Pro Arg Gly Val Glu Gln 
145                 150                 155                 160 


Arg Asn Lys Ala Leu Asp Trp Leu Arg Gly Arg Gly Gly Ala Val Gly 
                165                 170                 175     


Gly Glu Lys Asp Pro Pro Pro Pro Gly Thr Gln Gly Val Val Tyr Phe 
            180                 185                 190         


Ala Asp Asp Asp Asn Thr Tyr Ser Arg Glu Leu Phe Glu Glu Met Arg 
        195                 200                 205             


Trp Thr Arg Gly Val Ser Val Trp Pro Val Gly Leu Val Gly Gly Leu 
    210                 215                 220                 


Arg Phe Glu Gly Pro Gln Val Gln Asp Gly Arg Val Val Gly Phe His 
225                 230                 235                 240 


Thr Ala Trp Glu Pro Ser Arg Pro Phe Pro Val Asp Met Ala Gly Phe 
                245                 250                 255     


Ala Val Ala Leu Pro Leu Leu Leu Asp Lys Pro Asn Ala Gln Phe Asp 
            260                 265                 270         


Ser Thr Ala Pro Arg Gly His Leu Glu Ser Ser Leu Leu Ser His Leu 
        275                 280                 285             


Val Asp Pro Lys Asp Leu Glu Pro Arg Ala Ala Asn Cys Thr Arg Val 
    290                 295                 300                 


Leu Val Trp His Thr Arg Thr Glu Lys Pro Lys Met Lys Gln Glu Glu 
305                 310                 315                 320 


Gln Leu Gln Arg Gln Gly Arg Gly Ser Asp Pro Ala Ile Glu Val 
                325                 330                 335 


<210>  3721
<211>  1203
<212>  PRT
<213>  Homo sapiens

<400>  3721

Met Ala Ala Cys Gly Arg Val Arg Arg Met Phe Arg Leu Ser Ala Ala 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Phe Ala Ala Gly Ala Glu Lys Leu Pro Gly 
            20                  25                  30          


Gln Gly Val His Ser Gln Gly Gln Gly Pro Gly Ala Asn Phe Val Ser 
        35                  40                  45              


Phe Val Gly Gln Ala Gly Gly Gly Gly Pro Ala Gly Gln Gln Leu Pro 
    50                  55                  60                  


Gln Leu Pro Gln Ser Ser Gln Leu Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Gln Gln Gln Gln Pro Gln Pro Pro Gln Pro Pro Phe Pro Ala Gly Gly 
                85                  90                  95      


Pro Pro Ala Arg Arg Gly Gly Ala Gly Ala Gly Gly Gly Trp Lys Leu 
            100                 105                 110         


Ala Glu Glu Glu Ser Cys Arg Glu Asp Val Thr Arg Val Cys Pro Lys 
        115                 120                 125             


His Thr Trp Ser Asn Asn Leu Ala Val Leu Glu Cys Leu Gln Asp Val 
    130                 135                 140                 


Arg Glu Pro Glu Asn Glu Ile Ser Ser Asp Cys Asn His Leu Leu Trp 
145                 150                 155                 160 


Asn Tyr Lys Leu Asn Leu Thr Thr Asp Pro Lys Phe Glu Ser Val Ala 
                165                 170                 175     


Arg Glu Val Cys Lys Ser Thr Ile Thr Glu Ile Lys Glu Cys Ala Asp 
            180                 185                 190         


Glu Pro Val Gly Lys Gly Tyr Met Val Ser Cys Leu Val Asp His Arg 
        195                 200                 205             


Gly Asn Ile Thr Glu Tyr Gln Cys His Gln Tyr Ile Thr Lys Met Thr 
    210                 215                 220                 


Ala Ile Ile Phe Ser Asp Tyr Arg Leu Ile Cys Gly Phe Met Asp Asp 
225                 230                 235                 240 


Cys Lys Asn Asp Ile Asn Ile Leu Lys Cys Gly Ser Ile Arg Leu Gly 
                245                 250                 255     


Glu Lys Asp Ala His Ser Gln Gly Glu Val Val Ser Cys Leu Glu Lys 
            260                 265                 270         


Gly Leu Val Lys Glu Ala Glu Glu Arg Glu Pro Lys Ile Gln Val Ser 
        275                 280                 285             


Glu Leu Cys Lys Lys Ala Ile Leu Arg Val Ala Glu Leu Ser Ser Asp 
    290                 295                 300                 


Asp Phe His Leu Asp Arg His Leu Tyr Phe Ala Cys Arg Asp Asp Arg 
305                 310                 315                 320 


Glu Arg Phe Cys Glu Asn Thr Gln Ala Gly Glu Gly Arg Val Tyr Lys 
                325                 330                 335     


Cys Leu Phe Asn His Lys Phe Glu Glu Ser Met Ser Glu Lys Cys Arg 
            340                 345                 350         


Glu Ala Leu Thr Thr Arg Gln Lys Leu Ile Ala Gln Asp Tyr Lys Val 
        355                 360                 365             


Ser Tyr Ser Leu Ala Lys Ser Cys Lys Ser Asp Leu Lys Lys Tyr Arg 
    370                 375                 380                 


Cys Asn Val Glu Asn Leu Pro Arg Ser Arg Glu Ala Arg Leu Ser Tyr 
385                 390                 395                 400 


Leu Leu Met Cys Leu Glu Ser Ala Val His Arg Gly Arg Gln Val Ser 
                405                 410                 415     


Ser Glu Cys Gln Gly Glu Met Leu Asp Tyr Arg Arg Met Leu Met Glu 
            420                 425                 430         


Asp Phe Ser Leu Ser Pro Glu Ile Ile Leu Ser Cys Arg Gly Glu Ile 
        435                 440                 445             


Glu His His Cys Ser Gly Leu His Arg Lys Gly Arg Thr Leu His Cys 
    450                 455                 460                 


Leu Met Lys Val Val Arg Gly Glu Lys Gly Asn Leu Gly Met Asn Cys 
465                 470                 475                 480 


Gln Gln Ala Leu Gln Thr Leu Ile Gln Glu Thr Asp Pro Gly Ala Asp 
                485                 490                 495     


Tyr Arg Ile Asp Arg Ala Leu Asn Glu Ala Cys Glu Ser Val Ile Gln 
            500                 505                 510         


Thr Ala Cys Lys His Ile Arg Ser Gly Asp Pro Met Ile Leu Ser Cys 
        515                 520                 525             


Leu Met Glu His Leu Tyr Thr Glu Lys Met Val Glu Asp Cys Glu His 
    530                 535                 540                 


Arg Leu Leu Glu Leu Gln Tyr Phe Ile Ser Arg Asp Trp Lys Leu Asp 
545                 550                 555                 560 


Pro Val Leu Tyr Arg Lys Cys Gln Gly Asp Ala Ser Arg Leu Cys His 
                565                 570                 575     


Thr His Gly Trp Asn Glu Thr Ser Glu Phe Met Pro Gln Gly Ala Val 
            580                 585                 590         


Phe Ser Cys Leu Tyr Arg His Ala Tyr Arg Thr Glu Glu Gln Gly Arg 
        595                 600                 605             


Arg Leu Ser Arg Glu Cys Arg Ala Glu Val Gln Arg Ile Leu His Gln 
    610                 615                 620                 


Arg Ala Met Asp Val Lys Leu Asp Pro Ala Leu Gln Asp Lys Cys Leu 
625                 630                 635                 640 


Ile Asp Leu Gly Lys Trp Cys Ser Glu Lys Thr Glu Thr Gly Gln Glu 
                645                 650                 655     


Leu Glu Cys Leu Gln Asp His Leu Asp Asp Leu Val Val Glu Cys Arg 
            660                 665                 670         


Asp Ile Val Gly Asn Leu Thr Glu Leu Glu Ser Glu Asp Ile Gln Ile 
        675                 680                 685             


Glu Ala Leu Leu Met Arg Ala Cys Glu Pro Ile Ile Gln Asn Phe Cys 
    690                 695                 700                 


His Asp Val Ala Asp Asn Gln Ile Asp Ser Gly Asp Leu Met Glu Cys 
705                 710                 715                 720 


Leu Ile Gln Asn Lys His Gln Lys Asp Met Asn Glu Lys Cys Ala Ile 
                725                 730                 735     


Gly Val Thr His Phe Gln Leu Val Gln Met Lys Asp Phe Arg Phe Ser 
            740                 745                 750         


Tyr Lys Phe Lys Met Ala Cys Lys Glu Asp Val Leu Lys Leu Cys Pro 
        755                 760                 765             


Asn Ile Lys Lys Lys Val Asp Val Val Ile Cys Leu Ser Thr Thr Val 
    770                 775                 780                 


Arg Asn Asp Thr Leu Gln Glu Ala Lys Glu His Arg Val Ser Leu Lys 
785                 790                 795                 800 


Cys Arg Arg Gln Leu Arg Val Glu Glu Leu Glu Met Thr Glu Asp Ile 
                805                 810                 815     


Arg Leu Glu Pro Asp Leu Tyr Glu Ala Cys Lys Ser Asp Ile Lys Asn 
            820                 825                 830         


Phe Cys Ser Ala Val Gln Tyr Gly Asn Ala Gln Ile Ile Glu Cys Leu 
        835                 840                 845             


Lys Glu Asn Lys Lys Gln Leu Ser Thr Arg Cys His Gln Lys Val Phe 
    850                 855                 860                 


Lys Leu Gln Glu Thr Glu Met Met Asp Pro Glu Leu Asp Tyr Thr Leu 
865                 870                 875                 880 


Met Arg Val Cys Lys Gln Met Ile Lys Arg Phe Cys Pro Glu Ala Asp 
                885                 890                 895     


Ser Lys Thr Met Leu Gln Cys Leu Lys Gln Asn Lys Asn Ser Glu Leu 
            900                 905                 910         


Met Asp Pro Lys Cys Lys Gln Met Ile Thr Lys Arg Gln Ile Thr Gln 
        915                 920                 925             


Asn Thr Asp Tyr Arg Leu Asn Pro Met Leu Arg Lys Ala Cys Lys Ala 
    930                 935                 940                 


Asp Ile Pro Lys Phe Cys His Gly Ile Leu Thr Lys Ala Lys Asp Asp 
945                 950                 955                 960 


Ser Glu Leu Glu Gly Gln Val Ile Ser Cys Leu Lys Leu Arg Tyr Ala 
                965                 970                 975     


Asp Gln Arg Leu Ser Ser Asp Cys Glu Asp Gln Ile Arg Ile Ile Ile 
            980                 985                 990         


Gln Glu Ser Ala Leu Asp Tyr Arg  Leu Asp Pro Gln Leu  Gln Leu His 
        995                 1000                 1005             


Cys Ser  Asp Glu Ile Ser Ser  Leu Cys Ala Glu Glu  Ala Ala Ala 
    1010                 1015                 1020             


Gln Glu  Gln Thr Gly Gln Val  Glu Glu Cys Leu Lys  Val Asn Leu 
    1025                 1030                 1035             


Leu Lys  Ile Lys Thr Glu Leu  Cys Lys Lys Glu Val  Leu Asn Met 
    1040                 1045                 1050             


Leu Lys  Glu Ser Lys Ala Asp  Ile Phe Val Asp Pro  Val Leu His 
    1055                 1060                 1065             


Thr Ala  Cys Ala Leu Asp Ile  Lys His His Cys Ala  Ala Ile Thr 
    1070                 1075                 1080             


Pro Gly  Arg Gly Arg Gln Met  Ser Cys Leu Met Glu  Ala Leu Glu 
    1085                 1090                 1095             


Asp Lys  Arg Val Arg Leu Gln  Pro Glu Cys Lys Lys  Arg Leu Asn 
    1100                 1105                 1110             


Asp Arg  Ile Glu Met Trp Ser  Tyr Ala Ala Lys Val  Ala Pro Ala 
    1115                 1120                 1125             


Asp Gly  Phe Ser Asp Leu Ala  Met Gln Val Met Thr  Ser Pro Ser 
    1130                 1135                 1140             


Lys Asn  Tyr Ile Leu Ser Val  Ile Ser Gly Ser Ile  Cys Ile Leu 
    1145                 1150                 1155             


Phe Leu  Ile Gly Leu Met Cys  Gly Arg Ile Thr Lys  Arg Val Thr 
    1160                 1165                 1170             


Arg Glu  Leu Lys Asp Arg Leu  Gln Tyr Arg Ser Glu  Thr Met Ala 
    1175                 1180                 1185             


Tyr Lys  Gly Leu Val Trp Ser  Gln Asp Val Thr Gly  Ser Pro Ala 
    1190                 1195                 1200             


<210>  3722
<211>  506
<212>  PRT
<213>  Homo sapiens

<400>  3722

Met Pro Leu Leu Gly Leu Leu Pro Arg Arg Ala Trp Ala Ser Leu Leu 
1               5                   10                  15      


Ser Gln Leu Leu Arg Pro Pro Cys Ala Ser Cys Thr Gly Ala Val Arg 
            20                  25                  30          


Cys Gln Ser Gln Val Ala Glu Ala Val Leu Thr Ser Gln Leu Lys Ala 
        35                  40                  45              


His Gln Glu Lys Pro Asn Phe Ile Ile Lys Thr Pro Lys Gly Thr Arg 
    50                  55                  60                  


Asp Leu Ser Pro Gln His Met Val Val Arg Glu Lys Ile Leu Asp Leu 
65                  70                  75                  80  


Val Ile Ser Cys Phe Lys Arg His Gly Ala Lys Gly Met Asp Thr Pro 
                85                  90                  95      


Ala Phe Glu Leu Lys Glu Thr Leu Thr Glu Lys Tyr Gly Glu Asp Ser 
            100                 105                 110         


Gly Leu Met Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu 
        115                 120                 125             


Arg Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys 
    130                 135                 140                 


Val Lys Lys Met Lys Arg Tyr His Val Gly Lys Val Trp Arg Arg Glu 
145                 150                 155                 160 


Ser Pro Thr Ile Val Gln Gly Arg Tyr Arg Glu Phe Cys Gln Cys Asp 
                165                 170                 175     


Phe Asp Ile Ala Gly Gln Phe Asp Pro Met Ile Pro Asp Ala Glu Cys 
            180                 185                 190         


Leu Lys Ile Met Cys Glu Ile Leu Ser Gly Leu Gln Leu Gly Asp Phe 
        195                 200                 205             


Leu Ile Lys Val Asn Asp Arg Arg Ile Val Asp Gly Met Phe Ala Val 
    210                 215                 220                 


Cys Gly Val Pro Glu Ser Lys Phe Arg Ala Ile Cys Ser Ser Ile Asp 
225                 230                 235                 240 


Lys Leu Asp Lys Met Ala Trp Lys Asp Val Arg His Glu Met Val Val 
                245                 250                 255     


Lys Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val 
            260                 265                 270         


Gln Cys His Gly Gly Val Ser Leu Val Glu Gln Met Phe Gln Asp Pro 
        275                 280                 285             


Arg Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys 
    290                 295                 300                 


Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Ala Asp Lys Ile Ser 
305                 310                 315                 320 


Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile 
                325                 330                 335     


Tyr Glu Ala Val Leu Leu Gln Thr Pro Thr Gln Ala Gly Glu Glu Pro 
            340                 345                 350         


Leu Asn Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val 
        355                 360                 365             


Gly Met Phe Asp Pro Lys Gly His Lys Val Pro Cys Val Gly Leu Ser 
    370                 375                 380                 


Ile Gly Val Glu Arg Ile Phe Tyr Ile Val Glu Gln Arg Met Lys Thr 
385                 390                 395                 400 


Lys Gly Glu Lys Val Arg Thr Thr Glu Thr Gln Val Phe Val Ala Thr 
                405                 410                 415     


Pro Gln Lys Asn Phe Leu Gln Glu Arg Leu Lys Leu Ile Ala Glu Leu 
            420                 425                 430         


Trp Asp Ser Gly Ile Lys Ala Glu Met Leu Tyr Lys Asn Asn Pro Lys 
        435                 440                 445             


Leu Leu Thr Gln Leu His Tyr Cys Glu Ser Thr Gly Ile Pro Leu Val 
    450                 455                 460                 


Val Ile Ile Gly Glu Gln Glu Leu Lys Glu Gly Val Ile Lys Ile Arg 
465                 470                 475                 480 


Ser Val Ala Ser Arg Glu Glu Val Ala Ile Lys Arg Glu Asn Phe Val 
                485                 490                 495     


Ala Glu Ile Gln Lys Arg Leu Ser Glu Ser 
            500                 505     


<210>  3723
<211>  535
<212>  PRT
<213>  Homo sapiens

<400>  3723

Met Arg Leu Arg Asn Gly Thr Val Ala Thr Ala Leu Ala Phe Ile Thr 
1               5                   10                  15      


Ser Phe Leu Thr Leu Ser Trp Tyr Thr Thr Trp Gln Asn Gly Lys Glu 
            20                  25                  30          


Lys Leu Ile Ala Tyr Gln Arg Glu Phe Leu Ala Leu Lys Glu Arg Leu 
        35                  40                  45              


Arg Ile Ala Glu His Arg Ile Ser Gln Arg Ser Ser Glu Leu Asn Thr 
    50                  55                  60                  


Ile Val Gln Gln Phe Lys Arg Val Gly Ala Glu Thr Asn Gly Ser Lys 
65                  70                  75                  80  


Asp Ala Leu Asn Lys Phe Ser Asp Asn Thr Leu Lys Leu Leu Lys Glu 
                85                  90                  95      


Leu Thr Ser Lys Lys Ser Leu Gln Val Pro Ser Ile Tyr Tyr His Leu 
            100                 105                 110         


Pro His Leu Leu Lys Asn Glu Gly Ser Leu Gln Pro Ala Val Gln Ile 
        115                 120                 125             


Gly Asn Gly Arg Thr Gly Val Ser Ile Val Met Gly Ile Pro Thr Val 
    130                 135                 140                 


Lys Arg Glu Val Lys Ser Tyr Leu Ile Glu Thr Leu His Ser Leu Ile 
145                 150                 155                 160 


Asp Asn Leu Tyr Pro Glu Glu Lys Leu Asp Cys Val Ile Val Val Phe 
                165                 170                 175     


Ile Gly Glu Thr Asp Ile Asp Tyr Val His Gly Val Val Ala Asn Leu 
            180                 185                 190         


Glu Lys Glu Phe Ser Lys Glu Ile Ser Ser Gly Leu Val Glu Val Ile 
        195                 200                 205             


Ser Pro Pro Glu Ser Tyr Tyr Pro Asp Leu Thr Asn Leu Lys Glu Thr 
    210                 215                 220                 


Phe Gly Asp Ser Lys Glu Arg Val Arg Trp Arg Thr Lys Gln Asn Leu 
225                 230                 235                 240 


Asp Tyr Cys Phe Leu Met Met Tyr Ala Gln Glu Lys Gly Ile Tyr Tyr 
                245                 250                 255     


Ile Gln Leu Glu Asp Asp Ile Ile Val Lys Gln Asn Tyr Phe Asn Thr 
            260                 265                 270         


Ile Lys Asn Phe Ala Leu Gln Leu Ser Ser Glu Glu Trp Met Ile Leu 
        275                 280                 285             


Glu Phe Ser Gln Leu Gly Phe Ile Gly Lys Met Phe Gln Ala Pro Asp 
    290                 295                 300                 


Leu Thr Leu Ile Val Glu Phe Ile Phe Met Phe Tyr Lys Glu Lys Pro 
305                 310                 315                 320 


Ile Asp Trp Leu Leu Asp His Ile Leu Trp Val Lys Val Cys Asn Pro 
                325                 330                 335     


Glu Lys Asp Ala Lys His Cys Asp Arg Gln Lys Ala Asn Leu Arg Ile 
            340                 345                 350         


Arg Phe Arg Pro Ser Leu Phe Gln His Val Gly Leu His Ser Ser Leu 
        355                 360                 365             


Ser Gly Lys Ile Gln Lys Leu Thr Asp Lys Asp Tyr Met Lys Pro Leu 
    370                 375                 380                 


Leu Leu Lys Ile His Val Asn Pro Pro Ala Glu Val Ser Thr Ser Leu 
385                 390                 395                 400 


Lys Val Tyr Gln Gly His Thr Leu Glu Lys Thr Tyr Met Gly Glu Asp 
                405                 410                 415     


Phe Phe Trp Ala Ile Thr Pro Ile Ala Gly Asp Tyr Ile Leu Phe Lys 
            420                 425                 430         


Phe Asp Lys Pro Val Asn Val Glu Ser Tyr Leu Phe His Ser Gly Asn 
        435                 440                 445             


Gln Glu His Pro Gly Asp Ile Leu Leu Asn Thr Thr Val Glu Val Leu 
    450                 455                 460                 


Pro Phe Lys Ser Glu Gly Leu Glu Ile Ser Lys Glu Thr Lys Asp Lys 
465                 470                 475                 480 


Arg Leu Glu Asp Gly Tyr Phe Arg Ile Gly Lys Phe Glu Asn Gly Val 
                485                 490                 495     


Ala Glu Gly Met Val Asp Pro Ser Leu Asn Pro Ile Ser Ala Phe Arg 
            500                 505                 510         


Leu Ser Val Ile Gln Asn Ser Ala Val Trp Ala Ile Leu Asn Glu Ile 
        515                 520                 525             


His Ile Lys Lys Ala Thr Asn 
    530                 535 


<210>  3724
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  3724

Met Ala Ala Ala Gln Pro Lys Tyr Pro Ala Gly Ala Thr Ala Arg Arg 
1               5                   10                  15      


Leu Ala Arg Gly Cys Trp Ser Ala Leu Trp Asp Tyr Glu Thr Pro Lys 
            20                  25                  30          


Val Ile Val Val Arg Ile His Arg Ala Glu Lys Leu Pro Gly Glu Arg 
        35                  40                  45              


Asp Gly Pro Arg Glu Leu His His His Gln Gly Gln Gly Asp His His 
    50                  55                  60                  


Val Arg Ala Gln Ser Val Gly Arg Gly Gly Val Arg Glu Ala Pro Arg 
65                  70                  75                  80  


Gly Leu Arg Thr Gly Arg Cys Val Pro Tyr Tyr Gln Gly Pro Ser Lys 
                85                  90                  95      


Thr Cys Glu Val Phe Gly Trp Cys Pro Val Glu Asp Gly Ala Ser Val 
            100                 105                 110         


Ser Gln Phe Leu Gly Thr Met Ala Pro Asn Phe Thr Ile Leu Ile Lys 
        115                 120                 125             


Asn Ser Ile His Tyr Pro Lys Phe His Phe Ser Lys Gly Asn Ile Ala 
    130                 135                 140                 


Asp Arg Thr Asp Gly Tyr Leu Lys Arg Cys Thr Phe His Glu Ala Ser 
145                 150                 155                 160 


Asp Leu Tyr Cys Pro Ile Phe Lys Leu Gly Phe Ile Val Glu Lys Ala 
                165                 170                 175     


Gly Glu Ser Phe Thr Glu Leu Ala His Lys Gly Gly Val Ile Gly Val 
            180                 185                 190         


Ile Ile Asn Trp Asp Cys Asp Leu Asp Leu Pro Ala Ser Glu Cys Asn 
        195                 200                 205             


Pro Lys Tyr Ser Phe Arg Arg Leu Asp Pro Lys His Val Pro Ala Ser 
    210                 215                 220                 


Ser Gly Tyr Asn Phe Arg Phe Ala Lys Tyr Tyr Lys Ile Asn Gly Thr 
225                 230                 235                 240 


Thr Thr Arg Thr Leu Ile Lys Ala Tyr Gly Ile Arg Ile Asp Val Ile 
                245                 250                 255     


Val His Gly Gln Ala Gly Lys Phe Ser Leu Ile Pro Thr Ile Ile Asn 
            260                 265                 270         


Leu Ala Thr Ala Leu Thr Ser Val Gly Val Gly Ser Phe Leu Cys Asp 
        275                 280                 285             


Trp Ile Leu Leu Thr Phe Met Asn Lys Asn Lys Val Tyr Ser His Lys 
    290                 295                 300                 


Lys Phe Asp Lys Val Cys Thr Pro Ser His Pro Ser Gly Ser Trp Pro 
305                 310                 315                 320 


Val Thr Leu Ala Arg Val Leu Gly Gln Ala Pro Pro Glu Pro Gly His 
                325                 330                 335     


Arg Ser Glu Asp Gln His Pro Ser Pro Pro Ser Gly Gln Glu Gly Gln 
            340                 345                 350         


Gln Gly Ala Glu Cys Gly Pro Ala Phe Pro Pro Leu Arg Pro Cys Pro 
        355                 360                 365             


Ile Ser Ala Pro Ser Glu Gln Met Val Asp Thr Pro Ala Ser Glu Pro 
    370                 375                 380                 


Ala Gln Ala Ser Thr Pro Thr Asp Pro Lys Gly Leu Ala Gln Leu 
385                 390                 395                 


<210>  3725
<211>  1279
<212>  PRT
<213>  Homo sapiens

<400>  3725

Met Thr Leu Thr Glu Arg Leu Arg Glu Lys Ile Ser Arg Ala Phe Tyr 
1               5                   10                  15      


Asn His Gly Leu Leu Cys Ala Ser Tyr Pro Ile Pro Ile Ile Leu Phe 
            20                  25                  30          


Thr Gly Phe Cys Ile Leu Ala Cys Cys Tyr Pro Leu Leu Lys Leu Pro 
        35                  40                  45              


Leu Pro Gly Thr Gly Pro Val Glu Phe Thr Thr Pro Val Lys Asp Tyr 
    50                  55                  60                  


Ser Pro Pro Pro Val Asp Ser Asp Arg Lys Gln Gly Glu Pro Thr Glu 
65                  70                  75                  80  


Gln Pro Glu Trp Tyr Val Gly Ala Pro Val Ala Tyr Val Gln Gln Ile 
                85                  90                  95      


Phe Val Lys Ser Ser Val Phe Pro Trp His Lys Asn Leu Leu Ala Val 
            100                 105                 110         


Asp Val Phe Arg Ser Pro Leu Ser Arg Ala Phe Gln Leu Val Glu Glu 
        115                 120                 125             


Ile Arg Asn His Val Leu Arg Asp Ser Ser Gly Ile Arg Ser Leu Glu 
    130                 135                 140                 


Glu Leu Cys Leu Gln Val Thr Asp Leu Leu Pro Gly Leu Arg Lys Leu 
145                 150                 155                 160 


Arg Asn Leu Leu Pro Glu His Gly Cys Leu Leu Leu Ser Pro Gly Asn 
                165                 170                 175     


Phe Trp Gln Asn Asp Trp Glu Arg Phe His Ala Asp Pro Asp Ile Ile 
            180                 185                 190         


Gly Thr Ile His Gln His Glu Pro Lys Thr Leu Gln Thr Ser Ala Thr 
        195                 200                 205             


Leu Lys Asp Leu Leu Phe Gly Val Pro Gly Lys Tyr Ser Gly Val Ser 
    210                 215                 220                 


Leu Tyr Thr Arg Lys Arg Met Val Ser Tyr Thr Ile Thr Leu Val Phe 
225                 230                 235                 240 


Gln His Tyr His Ala Lys Phe Leu Gly Ser Leu Arg Ala Arg Leu Met 
                245                 250                 255     


Leu Leu His Pro Ser Pro Asn Cys Ser Leu Arg Ala Glu Ser Leu Val 
            260                 265                 270         


His Val His Phe Lys Glu Glu Ile Gly Val Ala Glu Leu Ile Pro Leu 
        275                 280                 285             


Val Thr Thr Tyr Ile Ile Leu Phe Ala Tyr Ile Tyr Phe Ser Thr Arg 
    290                 295                 300                 


Lys Ile Asp Met Val Lys Ser Lys Trp Gly Leu Ala Leu Ala Ala Val 
305                 310                 315                 320 


Val Thr Val Leu Ser Ser Leu Leu Met Ser Val Gly Leu Cys Thr Leu 
                325                 330                 335     


Phe Gly Leu Thr Pro Thr Leu Asn Gly Gly Glu Ile Phe Pro Tyr Leu 
            340                 345                 350         


Val Val Val Ile Gly Leu Glu Asn Val Leu Val Leu Thr Lys Ser Val 
        355                 360                 365             


Val Ser Thr Pro Val Asp Leu Glu Val Lys Leu Arg Ile Ala Gln Gly 
    370                 375                 380                 


Leu Ser Ser Glu Ser Trp Ser Ile Met Lys Asn Met Ala Thr Glu Leu 
385                 390                 395                 400 


Gly Ile Ile Leu Ile Gly Tyr Phe Thr Leu Val Pro Ala Ile Gln Glu 
                405                 410                 415     


Phe Cys Leu Phe Ala Val Val Gly Leu Val Ser Asp Phe Phe Leu Gln 
            420                 425                 430         


Met Leu Phe Phe Thr Thr Val Leu Ser Ile Asp Ile Arg Arg Met Glu 
        435                 440                 445             


Leu Ala Asp Leu Asn Lys Arg Leu Pro Pro Glu Ala Cys Leu Pro Ser 
    450                 455                 460                 


Ala Lys Pro Val Gly Gln Pro Thr Arg Tyr Glu Arg Gln Leu Ala Val 
465                 470                 475                 480 


Arg Pro Ser Thr Pro His Thr Ile Thr Leu Gln Pro Ser Ser Phe Arg 
                485                 490                 495     


Asn Leu Arg Leu Pro Lys Arg Leu Arg Val Val Tyr Phe Leu Ala Arg 
            500                 505                 510         


Thr Arg Leu Ala Gln Arg Leu Ile Met Ala Gly Thr Val Val Trp Ile 
        515                 520                 525             


Gly Ile Leu Val Tyr Thr Asp Pro Ala Gly Leu Arg Asn Tyr Leu Ala 
    530                 535                 540                 


Ala Gln Val Thr Glu Gln Ser Pro Leu Gly Glu Gly Ala Leu Ala Pro 
545                 550                 555                 560 


Met Pro Val Pro Ser Gly Met Leu Pro Pro Ser His Pro Asp Pro Ala 
                565                 570                 575     


Phe Ser Ile Phe Pro Pro Asp Ala Pro Lys Leu Pro Glu Asn Gln Thr 
            580                 585                 590         


Ser Pro Gly Glu Ser Pro Glu Arg Gly Gly Pro Ala Glu Val Val His 
        595                 600                 605             


Asp Ser Pro Val Pro Glu Val Thr Trp Gly Pro Glu Asp Glu Glu Leu 
    610                 615                 620                 


Trp Arg Lys Leu Ser Phe Arg His Trp Pro Thr Leu Phe Ser Tyr Tyr 
625                 630                 635                 640 


Asn Ile Thr Leu Ala Lys Arg Tyr Ile Ser Leu Leu Pro Val Ile Pro 
                645                 650                 655     


Val Thr Leu Arg Leu Asn Pro Arg Glu Ala Leu Glu Gly Arg His Pro 
            660                 665                 670         


Gln Asp Gly Arg Ser Ala Trp Pro Pro Pro Gly Pro Ile Pro Ala Gly 
        675                 680                 685             


His Trp Glu Ala Gly Pro Lys Gly Pro Gly Gly Val Gln Ala His Gly 
    690                 695                 700                 


Asp Val Thr Leu Tyr Lys Val Ala Ala Leu Gly Leu Ala Thr Gly Ile 
705                 710                 715                 720 


Val Leu Val Leu Leu Leu Leu Cys Leu Tyr Arg Val Leu Cys Pro Arg 
                725                 730                 735     


Asn Tyr Gly Gln Leu Gly Gly Gly Pro Gly Arg Arg Arg Arg Gly Glu 
            740                 745                 750         


Leu Pro Cys Asp Asp Tyr Gly Tyr Ala Pro Pro Glu Thr Glu Ile Val 
        755                 760                 765             


Pro Leu Val Leu Arg Gly His Leu Met Asp Ile Glu Cys Leu Ala Ser 
    770                 775                 780                 


Asp Gly Met Leu Leu Val Ser Cys Cys Leu Ala Gly His Val Cys Val 
785                 790                 795                 800 


Trp Asp Ala Gln Thr Gly Asp Cys Leu Thr Arg Ile Pro Arg Pro Gly 
                805                 810                 815     


Arg Gln Arg Arg Asp Ser Gly Val Gly Ser Gly Leu Glu Ala Gln Glu 
            820                 825                 830         


Ser Trp Glu Arg Leu Ser Asp Gly Gly Lys Ala Gly Pro Glu Glu Pro 
        835                 840                 845             


Gly Asp Ser Pro Pro Leu Arg His Arg Pro Arg Gly Pro Pro Pro Pro 
    850                 855                 860                 


Ser Leu Phe Gly Asp Gln Pro Asp Leu Thr Cys Leu Ile Asp Thr Asn 
865                 870                 875                 880 


Phe Ser Ala Gln Pro Arg Ser Ser Gln Pro Thr Gln Pro Glu Pro Arg 
                885                 890                 895     


His Arg Ala Val Cys Gly Arg Ser Arg Asp Ser Pro Gly Tyr Asp Phe 
            900                 905                 910         


Ser Cys Leu Val Gln Arg Val Tyr Gln Glu Glu Gly Leu Ala Ala Val 
        915                 920                 925             


Cys Thr Pro Ala Leu Arg Pro Pro Ser Pro Gly Pro Val Leu Ser Gln 
    930                 935                 940                 


Ala Pro Glu Asp Glu Gly Gly Ser Pro Glu Lys Gly Ser Pro Ser Leu 
945                 950                 955                 960 


Ala Trp Ala Pro Ser Ala Glu Gly Ser Ile Trp Ser Leu Glu Leu Gln 
                965                 970                 975     


Gly Asn Leu Ile Val Val Gly Arg Ser Ser Gly Arg Leu Glu Val Trp 
            980                 985                 990         


Asp Ala Ile Glu Gly Val Leu Cys  Cys Ser Ser Glu Glu  Val Ser Ser 
        995                 1000                 1005             


Gly Ile  Thr Ala Leu Val Phe  Leu Asp Lys Arg Ile  Val Ala Ala 
    1010                 1015                 1020             


Arg Leu  Asn Gly Ser Leu Asp  Phe Phe Ser Leu Glu  Thr His Thr 
    1025                 1030                 1035             


Ala Leu  Ser Pro Leu Gln Phe  Arg Gly Thr Pro Gly  Arg Gly Ser 
    1040                 1045                 1050             


Ser Pro  Ala Ser Pro Val Tyr  Ser Ser Ser Asp Thr  Val Ala Cys 
    1055                 1060                 1065             


His Leu  Thr His Thr Val Pro  Cys Ala His Gln Lys  Pro Ile Thr 
    1070                 1075                 1080             


Ala Leu  Lys Ala Ala Ala Gly  Arg Leu Val Thr Gly  Ser Gln Asp 
    1085                 1090                 1095             


His Thr  Leu Arg Val Phe Arg  Leu Glu Asp Ser Cys  Cys Leu Phe 
    1100                 1105                 1110             


Thr Leu  Gln Gly His Ser Gly  Ala Ile Thr Thr Val  Tyr Ile Asp 
    1115                 1120                 1125             


Gln Thr  Met Val Leu Ala Ser  Gly Gly Gln Asp Gly  Ala Ile Cys 
    1130                 1135                 1140             


Leu Trp  Asp Val Leu Thr Gly  Ser Arg Val Ser His  Val Phe Ala 
    1145                 1150                 1155             


His Arg  Gly Asp Val Thr Ser  Leu Thr Cys Thr Thr  Ser Cys Val 
    1160                 1165                 1170             


Ile Ser  Ser Gly Leu Asp Asp  Leu Ile Ser Ile Trp  Asp Arg Ser 
    1175                 1180                 1185             


Thr Gly  Ile Lys Phe Tyr Ser  Ile Gln Gln Asp Leu  Gly Cys Gly 
    1190                 1195                 1200             


Ala Ser  Leu Gly Val Ile Ser  Asp Asn Leu Leu Val  Thr Gly Gly 
    1205                 1210                 1215             


Gln Gly  Cys Val Ser Phe Trp  Asp Leu Asn Tyr Gly  Asp Leu Leu 
    1220                 1225                 1230             


Gln Thr  Val Tyr Leu Gly Lys  Asn Ser Glu Ala Gln  Pro Ala Arg 
    1235                 1240                 1245             


Gln Ile  Leu Val Leu Asp Asn  Ala Ala Ile Val Cys  Asn Phe Gly 
    1250                 1255                 1260             


Ser Glu  Leu Ser Leu Val Tyr  Val Pro Ser Val Leu  Glu Lys Leu 
    1265                 1270                 1275             


Asp 
    


<210>  3726
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  3726

Met Phe Ala Asn Leu Lys Tyr Val Ser Leu Gly Ile Leu Val Phe Gln 
1               5                   10                  15      


Thr Thr Ser Leu Val Leu Thr Met Arg Tyr Ser Arg Thr Leu Lys Glu 
            20                  25                  30          


Glu Gly Pro Arg Tyr Leu Ser Ser Thr Ala Val Val Val Ala Glu Leu 
        35                  40                  45              


Leu Lys Ile Met Ala Cys Ile Leu Leu Val Tyr Lys Asp Ser Lys Cys 
    50                  55                  60                  


Ser Leu Arg Ala Leu Asn Arg Val Leu His Asp Glu Ile Leu Asn Lys 
65                  70                  75                  80  


Pro Met Glu Thr Leu Lys Leu Ala Ile Pro Ser Gly Ile Tyr Thr Leu 
                85                  90                  95      


Gln Asn Asn Leu Leu Tyr Val Ala Leu Ser Asn Leu Asp Ala Ala Thr 
            100                 105                 110         


Tyr Gln Val Thr Tyr Gln Leu Lys Ile Leu Thr Thr Ala Leu Phe Ser 
        115                 120                 125             


Val Ser Met Leu Ser Lys Lys Leu Gly Val Tyr Gln Trp Leu Ser Leu 
    130                 135                 140                 


Val Ile Leu Met Thr Gly Val Ala Phe Val Gln Trp Pro Ser Asp Ser 
145                 150                 155                 160 


Gln Leu Asp Ser Lys Glu Leu Ser Ala Gly Ser Gln Phe Val Gly Leu 
                165                 170                 175     


Met Ala Val Leu Thr Ala Cys Phe Ser Ser Gly Phe Ala Gly Val Tyr 
            180                 185                 190         


Phe Glu Lys Ile Leu Lys Glu Thr Lys Gln Ser Val Trp Ile Arg Asn 
        195                 200                 205             


Ile Gln Leu Gly Phe Phe Gly Ser Ile Phe Gly Leu Met Gly Val Tyr 
    210                 215                 220                 


Ile Tyr Asp Gly Glu Leu Val Ser Lys Asn Gly Phe Phe Gln Gly Tyr 
225                 230                 235                 240 


Asn Arg Leu Thr Trp Ile Val Val Val Leu Gln Ala Leu Gly Gly Leu 
                245                 250                 255     


Val Ile Ala Ala Val Ile Lys Tyr Ala Asp Asn Ile Leu Lys Gly Phe 
            260                 265                 270         


Ala Thr Ser Leu Ser Ile Ile Leu Ser Thr Leu Ile Ser Tyr Phe Trp 
        275                 280                 285             


Leu Gln Asp Phe Val Pro Thr Ser Val Phe Phe Leu Gly Ala Ile Leu 
    290                 295                 300                 


Val Ile Thr Ala Thr Phe Leu Tyr Gly Tyr Asp Pro Lys Pro Ala Gly 
305                 310                 315                 320 


Asn Pro Thr Lys Ala 
                325 


<210>  3727
<211>  535
<212>  PRT
<213>  Homo sapiens

<400>  3727

Met Glu Glu Gly Ala Arg His Arg Asn Asn Thr Glu Lys Lys His Pro 
1               5                   10                  15      


Gly Gly Gly Glu Ser Asp Ala Ser Pro Glu Ala Gly Ser Gly Gly Gly 
            20                  25                  30          


Gly Val Ala Leu Lys Lys Glu Ile Gly Leu Val Ser Ala Cys Gly Ile 
        35                  40                  45              


Ile Val Gly Asn Ile Ile Gly Ser Gly Ile Phe Val Ser Pro Lys Gly 
    50                  55                  60                  


Val Leu Glu Asn Ala Gly Ser Val Gly Leu Ala Leu Ile Val Trp Ile 
65                  70                  75                  80  


Val Thr Gly Phe Ile Thr Val Val Gly Ala Leu Cys Tyr Ala Glu Leu 
                85                  90                  95      


Gly Val Thr Ile Pro Lys Ser Gly Gly Asp Tyr Ser Tyr Val Lys Asp 
            100                 105                 110         


Ile Phe Gly Gly Leu Ala Gly Phe Leu Arg Leu Trp Ile Ala Val Leu 
        115                 120                 125             


Val Ile Tyr Pro Thr Asn Gln Ala Val Ile Ala Leu Thr Phe Ser Asn 
    130                 135                 140                 


Tyr Val Leu Gln Pro Leu Phe Pro Thr Cys Phe Pro Pro Glu Ser Gly 
145                 150                 155                 160 


Leu Arg Leu Leu Ala Ala Ile Cys Leu Leu Leu Leu Thr Trp Val Asn 
                165                 170                 175     


Cys Ser Ser Val Arg Trp Ala Thr Arg Val Gln Asp Ile Phe Thr Ala 
            180                 185                 190         


Gly Lys Leu Leu Ala Leu Ala Leu Ile Ile Ile Met Gly Ile Val Gln 
        195                 200                 205             


Ile Cys Lys Gly Glu Tyr Phe Trp Leu Glu Pro Lys Asn Ala Phe Glu 
    210                 215                 220                 


Asn Phe Gln Glu Pro Asp Ile Gly Leu Val Ala Leu Ala Phe Leu Gln 
225                 230                 235                 240 


Gly Ser Phe Ala Tyr Gly Gly Trp Asn Phe Leu Asn Tyr Val Thr Glu 
                245                 250                 255     


Glu Leu Val Asp Pro Tyr Lys Asn Leu Pro Arg Ala Ile Phe Ile Ser 
            260                 265                 270         


Ile Pro Leu Val Thr Phe Val Tyr Val Phe Ala Asn Val Ala Tyr Val 
        275                 280                 285             


Thr Ala Met Ser Pro Gln Glu Leu Leu Ala Ser Asn Ala Val Ala Val 
    290                 295                 300                 


Thr Phe Gly Glu Lys Leu Leu Gly Val Met Ala Trp Ile Met Pro Ile 
305                 310                 315                 320 


Ser Val Ala Leu Ser Thr Phe Gly Gly Val Asn Gly Ser Leu Phe Thr 
                325                 330                 335     


Ser Ser Arg Leu Phe Phe Ala Gly Ala Arg Glu Gly His Leu Pro Ser 
            340                 345                 350         


Val Leu Ala Met Ile His Val Lys Arg Cys Thr Pro Ile Pro Ala Leu 
        355                 360                 365             


Leu Phe Thr Cys Ile Ser Thr Leu Leu Met Leu Val Thr Ser Asp Met 
    370                 375                 380                 


Tyr Thr Leu Ile Asn Tyr Val Gly Phe Ile Asn Tyr Leu Phe Tyr Gly 
385                 390                 395                 400 


Val Thr Val Ala Gly Gln Ile Val Leu Arg Trp Lys Lys Pro Asp Ile 
                405                 410                 415     


Pro Arg Pro Ile Lys Ile Asn Leu Leu Phe Pro Ile Ile Tyr Leu Leu 
            420                 425                 430         


Phe Trp Ala Phe Leu Leu Val Phe Ser Leu Trp Ser Glu Pro Val Val 
        435                 440                 445             


Cys Gly Ile Gly Leu Ala Ile Met Leu Thr Gly Val Pro Val Tyr Phe 
    450                 455                 460                 


Leu Gly Val Tyr Trp Gln His Lys Pro Lys Cys Phe Ser Asp Phe Ile 
465                 470                 475                 480 


Glu Leu Leu Thr Leu Val Ser Gln Lys Met Cys Val Val Val Tyr Pro 
                485                 490                 495     


Glu Val Glu Arg Gly Ser Gly Thr Glu Glu Ala Asn Glu Asp Met Glu 
            500                 505                 510         


Glu Gln Gln Gln Pro Met Tyr Gln Pro Thr Pro Thr Lys Asp Lys Asp 
        515                 520                 525             


Val Ala Gly Gln Pro Gln Pro 
    530                 535 


<210>  3728
<211>  690
<212>  PRT
<213>  Homo sapiens

<400>  3728

Met Gly Val Arg Gln Gln Leu Ala Leu Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Trp Gly Leu Gly Gln Pro Val Trp Pro Val Ala Val Ala Leu Thr 
            20                  25                  30          


Leu Arg Trp Leu Leu Gly Asp Pro Thr Cys Cys Val Leu Leu Gly Leu 
        35                  40                  45              


Ala Met Leu Ala Arg Pro Trp Leu Gly Pro Trp Val Pro His Gly Leu 
    50                  55                  60                  


Ser Leu Ala Ala Ala Ala Leu Ala Leu Thr Leu Leu Pro Ala Arg Leu 
65                  70                  75                  80  


Pro Pro Gly Leu Arg Trp Leu Pro Ala Asp Val Ile Phe Leu Ala Lys 
                85                  90                  95      


Ile Leu His Leu Gly Leu Lys Ile Arg Gly Cys Leu Ser Arg Gln Pro 
            100                 105                 110         


Pro Asp Thr Phe Val Asp Ala Phe Glu Arg Arg Ala Arg Ala Gln Pro 
        115                 120                 125             


Gly Arg Ala Leu Leu Val Trp Thr Gly Pro Gly Ala Gly Ser Val Thr 
    130                 135                 140                 


Phe Gly Glu Leu Asp Ala Arg Ala Cys Gln Ala Ala Trp Ala Leu Lys 
145                 150                 155                 160 


Ala Glu Leu Gly Asp Pro Ala Ser Leu Cys Ala Gly Glu Pro Thr Ala 
                165                 170                 175     


Leu Leu Val Leu Ala Ser Gln Ala Val Pro Ala Leu Cys Met Trp Leu 
            180                 185                 190         


Gly Leu Ala Lys Leu Gly Cys Pro Thr Ala Trp Ile Asn Pro His Gly 
        195                 200                 205             


Arg Gly Met Pro Leu Ala His Ser Val Leu Ser Ser Gly Ala Arg Val 
    210                 215                 220                 


Leu Val Val Asp Pro Asp Leu Arg Glu Ser Leu Glu Glu Ile Leu Pro 
225                 230                 235                 240 


Lys Leu Gln Ala Glu Asn Ile Arg Cys Phe Tyr Leu Ser His Thr Ser 
                245                 250                 255     


Pro Thr Pro Gly Val Gly Ala Leu Gly Ala Ala Leu Asp Ala Ala Pro 
            260                 265                 270         


Ser His Pro Val Pro Ala Asp Leu Arg Ala Gly Ile Thr Trp Arg Ser 
        275                 280                 285             


Pro Ala Leu Phe Ile Tyr Thr Ser Gly Thr Thr Gly Leu Pro Lys Pro 
    290                 295                 300                 


Ala Ile Leu Thr His Glu Arg Val Leu Gln Met Ser Lys Met Leu Ser 
305                 310                 315                 320 


Leu Ser Gly Ala Thr Ala Asp Asp Val Val Tyr Thr Val Leu Pro Leu 
                325                 330                 335     


Tyr His Val Met Gly Leu Val Val Gly Ile Leu Gly Cys Leu Asp Leu 
            340                 345                 350         


Gly Ala Thr Cys Val Leu Ala Pro Lys Phe Ser Thr Ser Cys Phe Trp 
        355                 360                 365             


Asp Asp Cys Arg Gln His Gly Val Thr Val Ile Leu Tyr Val Gly Glu 
    370                 375                 380                 


Leu Leu Arg Tyr Leu Cys Asn Ile Pro Gln Gln Pro Glu Asp Arg Thr 
385                 390                 395                 400 


His Thr Val Arg Leu Ala Met Gly Asn Gly Leu Arg Ala Asp Val Trp 
                405                 410                 415     


Glu Thr Phe Gln Gln Arg Phe Gly Pro Ile Arg Ile Trp Glu Val Tyr 
            420                 425                 430         


Gly Ser Thr Glu Gly Asn Met Gly Leu Val Asn Tyr Val Gly Arg Cys 
        435                 440                 445             


Gly Ala Leu Gly Lys Met Ser Cys Leu Leu Arg Met Leu Ser Pro Phe 
    450                 455                 460                 


Glu Leu Val Gln Phe Asp Met Glu Ala Ala Glu Pro Val Arg Asp Asn 
465                 470                 475                 480 


Gln Gly Phe Cys Ile Pro Val Gly Leu Gly Glu Pro Gly Leu Leu Leu 
                485                 490                 495     


Thr Lys Val Val Ser Gln Gln Pro Phe Val Gly Tyr Arg Gly Pro Arg 
            500                 505                 510         


Glu Leu Ser Glu Arg Lys Leu Val Arg Asn Val Arg Gln Ser Gly Asp 
        515                 520                 525             


Val Tyr Tyr Asn Thr Gly Asp Val Leu Ala Met Asp Arg Glu Gly Phe 
    530                 535                 540                 


Leu Tyr Phe Arg Asp Arg Leu Gly Asp Thr Phe Arg Trp Lys Gly Glu 
545                 550                 555                 560 


Asn Val Ser Thr His Glu Val Glu Gly Val Leu Ser Gln Val Asp Phe 
                565                 570                 575     


Leu Gln Gln Val Asn Val Tyr Gly Val Cys Val Pro Gly Cys Glu Gly 
            580                 585                 590         


Lys Val Gly Met Ala Ala Val Gln Leu Ala Pro Gly Gln Thr Phe Asp 
        595                 600                 605             


Gly Glu Lys Leu Tyr Gln His Val Arg Ala Trp Leu Pro Ala Tyr Ala 
    610                 615                 620                 


Thr Pro His Phe Ile Arg Ile Gln Asp Ala Met Glu Val Thr Ser Thr 
625                 630                 635                 640 


Phe Lys Leu Met Lys Thr Arg Leu Val Arg Glu Gly Phe Asn Val Gly 
                645                 650                 655     


Ile Val Val Asp Pro Leu Phe Val Leu Asp Asn Arg Ala Gln Ser Phe 
            660                 665                 670         


Arg Pro Leu Thr Ala Glu Met Tyr Gln Ala Val Cys Glu Gly Thr Trp 
        675                 680                 685             


Arg Leu 
    690 


<210>  3729
<211>  280
<212>  PRT
<213>  Homo sapiens

<400>  3729

Met Asp Leu Gln Gly Arg Gly Val Pro Ser Ile Asp Arg Leu Arg Val 
1               5                   10                  15      


Leu Leu Met Leu Phe His Thr Met Ala Gln Ile Met Ala Glu Gln Glu 
            20                  25                  30          


Val Glu Asn Leu Ser Gly Leu Ser Thr Asn Pro Glu Lys Asp Ile Phe 
        35                  40                  45              


Val Val Arg Glu Asn Gly Thr Thr Cys Leu Met Ala Glu Phe Ala Ala 
    50                  55                  60                  


Lys Phe Ile Val Pro Tyr Asp Val Trp Ala Ser Asn Tyr Val Asp Leu 
65                  70                  75                  80  


Ile Thr Glu Gln Ala Asp Ile Ala Leu Thr Arg Gly Ala Glu Val Lys 
                85                  90                  95      


Gly Arg Cys Gly His Ser Gln Ser Glu Leu Gln Val Phe Trp Val Asp 
            100                 105                 110         


Arg Ala Tyr Ala Leu Lys Met Leu Phe Val Lys Glu Ser His Asn Met 
        115                 120                 125             


Ser Lys Gly Pro Glu Ala Thr Trp Arg Leu Ser Lys Val Gln Phe Val 
    130                 135                 140                 


Tyr Asp Ser Ser Glu Lys Thr His Phe Lys Asp Ala Val Ser Ala Gly 
145                 150                 155                 160 


Lys His Thr Ala Asn Ser His His Leu Ser Ala Leu Val Thr Pro Ala 
                165                 170                 175     


Gly Lys Ser Tyr Glu Cys Gln Ala Gln Gln Thr Ile Ser Leu Ala Ser 
            180                 185                 190         


Ser Asp Pro Gln Lys Thr Val Thr Met Ile Leu Ser Ala Val His Ile 
        195                 200                 205             


Gln Pro Phe Asp Ile Ile Ser Asp Phe Val Phe Ser Glu Glu His Lys 
    210                 215                 220                 


Cys Pro Val Asp Glu Arg Glu Gln Leu Glu Glu Thr Leu Pro Leu Ile 
225                 230                 235                 240 


Leu Gly Leu Ile Leu Gly Leu Val Ile Met Val Thr Leu Ala Ile Tyr 
                245                 250                 255     


His Val His His Lys Met Thr Ala Asn Gln Val Gln Ile Pro Arg Asp 
            260                 265                 270         


Arg Ser Gln Tyr Lys His Met Gly 
        275                 280 


<210>  3730
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  3730

Met Thr Val Arg Gly Asp Val Leu Ala Pro Asp Pro Ala Ser Pro Thr 
1               5                   10                  15      


Thr Ala Ala Ala Ser Pro Ser Val Ser Val Ile Pro Glu Gly Ser Pro 
            20                  25                  30          


Thr Ala Met Glu Gln Pro Val Phe Leu Met Thr Thr Ala Ala Gln Ala 
        35                  40                  45              


Ile Ser Gly Phe Phe Val Trp Thr Ala Leu Leu Ile Thr Cys His Gln 
    50                  55                  60                  


Ile Tyr Met His Leu Arg Cys Tyr Ser Cys Pro Asn Glu Gln Arg Tyr 
65                  70                  75                  80  


Ile Val Arg Ile Leu Phe Ile Val Pro Ile Tyr Ala Phe Asp Ser Trp 
                85                  90                  95      


Leu Ser Leu Leu Phe Phe Thr Asn Asp Gln Tyr Tyr Val Tyr Phe Gly 
            100                 105                 110         


Thr Val Arg Asp Cys Tyr Glu Ala Leu Val Ile Tyr Asn Phe Leu Ser 
        115                 120                 125             


Leu Cys Tyr Glu Tyr Leu Gly Gly Glu Ser Ser Ile Met Ser Glu Ile 
    130                 135                 140                 


Arg Gly Lys Pro Ile Glu Ser Ser Cys Met Tyr Gly Thr Cys Cys Leu 
145                 150                 155                 160 


Trp Gly Lys Thr Tyr Ser Ile Gly Phe Leu Arg Phe Cys Lys Gln Ala 
                165                 170                 175     


Thr Leu Gln Phe Cys Val Val Lys Pro Leu Met Ala Val Ser Thr Val 
            180                 185                 190         


Val Leu Gln Ala Phe Gly Lys Tyr Arg Asp Gly Asp Phe Asp Val Thr 
        195                 200                 205             


Ser Gly Tyr Leu Tyr Val Thr Ile Ile Tyr Asn Ile Ser Val Ser Leu 
    210                 215                 220                 


Ala Leu Tyr Ala Leu Phe Leu Phe Tyr Phe Ala Thr Arg Glu Leu Leu 
225                 230                 235                 240 


Ser Pro Tyr Ser Pro Val Leu Lys Phe Phe Met Val Lys Ser Val Ile 
                245                 250                 255     


Phe Leu Ser Phe Trp Gln Gly Met Leu Leu Ala Ile Leu Glu Lys Cys 
            260                 265                 270         


Gly Ala Ile Pro Lys Ile His Ser Ala Arg Val Ser Val Gly Glu Gly 
        275                 280                 285             


Thr Val Ala Ala Gly Tyr Gln Asp Phe Ile Ile Cys Val Glu Met Phe 
    290                 295                 300                 


Phe Ala Ala Leu Ala Leu Arg His Ala Phe Thr Tyr Lys Val Tyr Ala 
305                 310                 315                 320 


Asp Lys Arg Leu Asp Ala Gln Gly Arg Cys Ala Pro Met Lys Ser Ile 
                325                 330                 335     


Ser Ser Ser Leu Lys Glu Thr Met Asn Pro His Asp Ile Val Gln Asp 
            340                 345                 350         


Ala Ile His Asn Phe Ser Pro Ala Tyr Gln Gln Tyr Thr Gln Gln Ser 
        355                 360                 365             


Thr Leu Glu Pro Gly Pro Thr Trp Arg Gly Gly Ala His Gly Leu Ser 
    370                 375                 380                 


Arg Ser His Ser Leu Ser Gly Ala Arg Asp Asn Glu Lys Thr Leu Leu 
385                 390                 395                 400 


Leu Ser Ser Asp Asp Glu Phe 
                405         


<210>  3731
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  3731

Met His Ala Arg Gly Pro His Gly Gln Leu Ser Pro Ala Leu Pro Leu 
1               5                   10                  15      


Ala Ser Ser Val Leu Met Leu Leu Met Ser Thr Leu Trp Leu Val Gly 
            20                  25                  30          


Ala Gly Pro Gly Leu Val Leu Ala Pro Glu Leu Leu Leu Asp Pro Trp 
        35                  40                  45              


Gln Val His Arg Leu Leu Thr His Ala Leu Gly His Thr Ala Leu Pro 
    50                  55                  60                  


Gly Leu Leu Leu Ser Leu Leu Leu Leu Pro Thr Val Gly Trp Gln Gln 
65                  70                  75                  80  


Glu Cys His Leu Gly Thr Leu Arg Phe Leu His Ala Ser Ala Leu Leu 
                85                  90                  95      


Ala Leu Ala Ser Gly Leu Leu Ala Val Leu Leu Ala Gly Leu Gly Leu 
            100                 105                 110         


Ser Ser Ala Ala Gly Ser Cys Gly Tyr Met Pro Val His Leu Ala Met 
        115                 120                 125             


Leu Ala Gly Glu Gly His Arg Pro Arg Arg Pro Arg Gly Ala Leu Pro 
    130                 135                 140                 


Pro Trp Leu Ser Pro Trp Leu Leu Leu Ala Leu Thr Pro Leu Leu Ser 
145                 150                 155                 160 


Ser Glu Pro Pro Phe Leu Gln Leu Leu Cys Gly Leu Leu Ala Gly Leu 
                165                 170                 175     


Ala Tyr Ala Ala Gly Ala Phe Arg Trp Leu Glu Pro Ser Glu Arg Arg 
            180                 185                 190         


Leu Gln Val Leu Gln Glu Gly Val Leu Cys Arg Thr Leu Ala Gly Cys 
        195                 200                 205             


Trp Pro Leu Arg Leu Leu Ala Thr Pro Gly Ser Leu Ala Glu Leu Pro 
    210                 215                 220                 


Val Thr His Pro Ala Gly Val Arg Pro Pro Ile Pro Gly Pro Pro Tyr 
225                 230                 235                 240 


Val Ala Ser Pro Asp Leu Trp Ser His Trp Glu Asp Ser Ala Leu Pro 
                245                 250                 255     


Pro Pro Ser Leu Arg Pro Val Gln Pro Thr Trp Glu Gly Ser Ser Glu 
            260                 265                 270         


Ala Gly Leu Asp Trp Ala Gly Ala Ser Phe Ser Pro Gly Thr Pro Met 
        275                 280                 285             


Trp Ala Ala Leu Asp Glu Gln Met Leu Gln Glu Gly Ile Gln Ala Ser 
    290                 295                 300                 


Leu Leu Asp Gly Pro Ala Gln Glu Pro Gln Ser Ala Pro Trp Leu Ser 
305                 310                 315                 320 


Lys Ser Ser Val Ser Ser Leu Arg Leu Gln Gln Leu Glu Arg Met Gly 
                325                 330                 335     


Phe Pro Thr Glu Gln Ala Val Val Ala Leu Ala Ala Thr Gly Arg Val 
            340                 345                 350         


Glu Gly Ala Val Ser Leu Leu Val Gly Gly Gln Val Gly Thr Glu Thr 
        355                 360                 365             


Leu Val Thr His Gly Lys Gly Gly Pro Ala His Ser Glu Gly Pro Gly 
    370                 375                 380                 


Pro Pro 
385     


<210>  3732
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  3732

Met Lys Pro Lys Leu Met Tyr Gln Glu Leu Lys Val Pro Ala Glu Glu 
1               5                   10                  15      


Pro Ala Asn Glu Leu Pro Met Asn Glu Ile Glu Ala Trp Lys Ala Ala 
            20                  25                  30          


Glu Lys Lys Ala Arg Trp Val Leu Leu Val Leu Ile Leu Ala Val Val 
        35                  40                  45              


Gly Phe Gly Ala Leu Met Thr Gln Leu Phe Leu Trp Glu Tyr Gly Asp 
    50                  55                  60                  


Leu His Leu Phe Gly Pro Asn Gln Arg Pro Ala Pro Cys Tyr Asp Pro 
65                  70                  75                  80  


Cys Glu Ala Val Leu Val Glu Ser Ile Pro Glu Gly Leu Asp Phe Pro 
                85                  90                  95      


Asn Ala Ser Thr Gly Asn Pro Ser Thr Ser Gln Ala Trp Leu Gly Leu 
            100                 105                 110         


Leu Ala Gly Ala His Ser Ser Leu Asp Ile Ala Ser Phe Tyr Trp Thr 
        115                 120                 125             


Leu Thr Asn Asn Asp Thr His Thr Gln Glu Pro Ser Ala Gln Gln Gly 
    130                 135                 140                 


Glu Glu Val Leu Arg Gln Leu Gln Thr Leu Ala Pro Lys Gly Val Asn 
145                 150                 155                 160 


Val Arg Ile Ala Val Ser Lys Pro Ser Gly Pro Gln Pro Gln Ala Asp 
                165                 170                 175     


Leu Gln Ala Leu Leu Gln Ser Gly Ala Gln Val Arg Met Val Asp Met 
            180                 185                 190         


Gln Lys Leu Thr His Gly Val Leu His Thr Lys Phe Trp Val Val Asp 
        195                 200                 205             


Gln Thr His Phe Tyr Leu Gly Ser Ala Asn Met Asp Trp Arg Ser Leu 
    210                 215                 220                 


Thr Gln Val Lys Glu Leu Gly Val Val Met Tyr Asn Cys Ser Cys Leu 
225                 230                 235                 240 


Ala Arg Asp Leu Thr Lys Ile Phe Glu Ala Tyr Trp Phe Leu Gly Gln 
                245                 250                 255     


Ala Gly Ser Ser Ile Pro Ser Thr Trp Pro Arg Phe Tyr Asp Thr Arg 
            260                 265                 270         


Tyr Asn Gln Glu Thr Pro Met Glu Ile Cys Leu Asn Gly Thr Pro Ala 
        275                 280                 285             


Leu Ala Tyr Leu Ala Ser Ala Pro Pro Pro Leu Cys Pro Ser Gly Arg 
    290                 295                 300                 


Thr Pro Asp Leu Lys Ala Leu Leu Asn Val Val Asp Asn Ala Arg Ser 
305                 310                 315                 320 


Phe Ile Tyr Val Ala Val Met Asn Tyr Leu Pro Thr Leu Glu Phe Ser 
                325                 330                 335     


His Pro His Arg Phe Trp Pro Ala Ile Asp Asp Gly Leu Arg Arg Ala 
            340                 345                 350         


Thr Tyr Glu Arg Gly Val Lys Val Arg Leu Leu Ile Ser Cys Trp Gly 
        355                 360                 365             


His Ser Glu Pro Ser Met Arg Ala Phe Leu Leu Ser Leu Ala Ala Leu 
    370                 375                 380                 


Arg Asp Asn His Thr His Ser Asp Ile Gln Val Lys Leu Phe Val Val 
385                 390                 395                 400 


Pro Ala Asp Glu Ala Gln Ala Arg Ile Pro Tyr Ala Arg Val Asn His 
                405                 410                 415     


Asn Lys Tyr Met Val Thr Glu Arg Ala Thr Tyr Ile Gly Thr Ser Asn 
            420                 425                 430         


Trp Ser Gly Asn Tyr Phe Thr Glu Thr Ala Gly Thr Ser Leu Leu Val 
        435                 440                 445             


Thr Gln Asn Gly Arg Gly Gly Leu Arg Ser Gln Leu Glu Ala Ile Phe 
    450                 455                 460                 


Leu Arg Asp Trp Asp Ser Pro Tyr Ser His Asp Leu Asp Thr Ser Ala 
465                 470                 475                 480 


Asp Ser Val Gly Asn Ala Cys Arg Leu Leu 
                485                 490 


<210>  3733
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  3733

Met Lys Val Leu Ser Glu Gly Gln Leu Lys Leu Cys Val Val Gln Pro 
1               5                   10                  15      


Val His Leu Thr Ser Trp Leu Leu Ile Phe Phe Ile Leu Lys Ser Ile 
            20                  25                  30          


Ser Cys Leu Lys Pro Ala Arg Leu Pro Ile Tyr Gln Arg Lys Pro Phe 
        35                  40                  45              


Ile Ala Ala Trp Asn Ala Pro Thr Asp Gln Cys Leu Ile Lys Tyr Asn 
    50                  55                  60                  


Leu Arg Leu Asn Leu Lys Met Phe Pro Val Ile Gly Ser Pro Leu Ala 
65                  70                  75                  80  


Lys Ala Arg Gly Gln Asn Val Thr Ile Phe Tyr Val Asn Arg Leu Gly 
                85                  90                  95      


Tyr Tyr Pro Trp Tyr Thr Ser Gln Gly Val Pro Ile Asn Gly Gly Leu 
            100                 105                 110         


Pro Gln Asn Ile Ser Leu Gln Val His Leu Glu Lys Ala Asp Gln Asp 
        115                 120                 125             


Ile Asn Tyr Tyr Ile Pro Ala Glu Asp Phe Ser Gly Leu Ala Val Ile 
    130                 135                 140                 


Asp Trp Glu Tyr Trp Arg Pro Gln Trp Ala Arg Asn Trp Asn Ser Lys 
145                 150                 155                 160 


Asp Val Tyr Arg Gln Lys Ser Arg Lys Leu Ile Ser Asp Met Gly Lys 
                165                 170                 175     


Asn Val Ser Ala Thr Asp Ile Glu Tyr Leu Ala Lys Val Thr Phe Glu 
            180                 185                 190         


Glu Ser Ala Lys Ala Phe Met Lys Glu Thr Ile Lys Leu Gly Ile Lys 
        195                 200                 205             


Ser Arg Pro Lys Gly Leu Trp Gly Tyr Tyr Leu Tyr Pro Asp Cys His 
    210                 215                 220                 


Asn Tyr Asn Val Tyr Ala Pro Asn Tyr Ser Gly Ser Cys Pro Glu Asp 
225                 230                 235                 240 


Glu Val Leu Arg Asn Asn Glu Leu Ser Trp Leu Trp Asn Ser Ser Ala 
                245                 250                 255     


Ala Leu Tyr Pro Ser Ile Gly Val Trp Lys Ser Leu Gly Asp Ser Glu 
            260                 265                 270         


Asn Ile Leu Arg Phe Ser Lys Phe Arg Val His Glu Ser Met Arg Ile 
        275                 280                 285             


Ser Thr Met Thr Ser His Asp Tyr Ala Leu Pro Val Phe Val Tyr Thr 
    290                 295                 300                 


Arg Leu Gly Tyr Arg Asp Glu Pro Leu Phe Phe Leu Ser Lys Gln Asp 
305                 310                 315                 320 


Leu Val Ser Thr Ile Gly Glu Ser Ala Ala Leu Gly Ala Ala Gly Ile 
                325                 330                 335     


Val Ile Trp Gly Asp Met Asn Leu Thr Ala Ser Lys Ala Asn Cys Thr 
            340                 345                 350         


Lys Val Lys Gln Phe Val Ser Ser Asp Leu Gly Ser Tyr Ile Ala Asn 
        355                 360                 365             


Val Thr Arg Ala Ala Glu Val Cys Ser Leu His Leu Cys Arg Asn Asn 
    370                 375                 380                 


Gly Arg Cys Ile Arg Lys Met Trp Asn Ala Pro Ser Tyr Leu His Leu 
385                 390                 395                 400 


Asn Pro Ala Ser Tyr His Ile Glu Ala Ser Glu Asp Gly Glu Phe Thr 
                405                 410                 415     


Val Lys Gly Lys Ala Ser Asp Thr Asp Leu Ala Val Met Ala Asp Thr 
            420                 425                 430         


Phe Ser Cys His Cys Tyr Gln Gly Tyr Glu Gly Ala Asp Cys Arg Glu 
        435                 440                 445             


Ile Lys Thr Ala Asp Gly Cys Ser Gly Val Ser Pro Ser Pro Gly Ser 
    450                 455                 460                 


Leu Met Thr Leu Cys Leu Leu Leu Leu Ala Ser Tyr Arg Ser Ile Gln 
465                 470                 475                 480 


Leu 
    


<210>  3734
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  3734

Met Asn Cys Ser Glu Ser Gln Arg Leu Arg Thr Leu Leu Ser Arg Leu 
1               5                   10                  15      


Leu Leu Glu Leu His His Arg Gly Asn Ala Ser Gly Leu Gly Ala Gly 
            20                  25                  30          


Pro Arg Pro Ser Met Gly Met Gly Val Val Pro Asp Pro Phe Val Gly 
        35                  40                  45              


Arg Glu Val Thr Ser Ala Lys Gly Asp Asp Ala Tyr Leu Tyr Ile Leu 
    50                  55                  60                  


Leu Ile Met Ile Phe Tyr Ala Cys Leu Ala Gly Gly Leu Ile Leu Ala 
65                  70                  75                  80  


Tyr Thr Arg Ser Arg Lys Leu Val Glu Ala Lys Asp Glu Pro Ser Gln 
                85                  90                  95      


Ala Cys Ala Glu His Glu Trp Ala Pro Gly Gly Ala Leu Thr Ala Asp 
            100                 105                 110         


Ala Glu Ala Ala Ala Gly Ser Gln Ala Glu Gly Arg Arg Gln Leu Ala 
        115                 120                 125             


Ser Glu Gly Leu Pro Ala Leu Ala Gln Gly Ala Glu Arg Val 
    130                 135                 140         


<210>  3735
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  3735

Met Glu Pro Trp Pro Cys Ser Pro Gly Gly Gly Gly Gly Thr Arg Ala 
1               5                   10                  15      


Arg His Val Ile Ile Asn Val Gly Gly Cys Arg Val Arg Leu Ala Trp 
            20                  25                  30          


Ala Ala Leu Ala Arg Cys Pro Leu Ala Arg Leu Glu Arg Leu Arg Ala 
        35                  40                  45              


Cys Arg Gly His Asp Asp Leu Leu Arg Val Cys Asp Asp Tyr Asp Val 
    50                  55                  60                  


Ser Arg Asp Glu Phe Phe Phe Asp Arg Ser Pro Cys Ala Phe Arg Ala 
65                  70                  75                  80  


Ile Val Ala Leu Leu Arg Ala Gly Lys Leu Arg Leu Leu Arg Gly Pro 
                85                  90                  95      


Cys Ala Leu Ala Phe Arg Asp Glu Leu Ala Tyr Trp Gly Ile Asp Glu 
            100                 105                 110         


Ala Arg Leu Glu Arg Cys Cys Leu Arg Arg Leu Arg Arg Arg Glu Glu 
        115                 120                 125             


Glu Ala Ala Glu Ala Arg Ala Gly Pro Thr Glu Arg Gly Ala Gln Gly 
    130                 135                 140                 


Ser Pro Ala Arg Ala Leu Gly Pro Arg Gly Arg Leu Gln Arg Gly Arg 
145                 150                 155                 160 


Arg Arg Leu Arg Asp Val Val Asp Asn Pro His Ser Gly Leu Ala Gly 
                165                 170                 175     


Lys Leu Phe Ala Cys Val Ser Val Ser Phe Val Ala Val Thr Ala Val 
            180                 185                 190         


Gly Leu Cys Leu Ser Thr Met Pro Asp Ile Arg Ala Glu Glu Glu Arg 
        195                 200                 205             


Gly Glu Cys Ser Pro Lys Cys Arg Ser Leu Phe Val Leu Glu Thr Val 
    210                 215                 220                 


Cys Val Ala Trp Phe Ser Phe Glu Phe Leu Leu Arg Ser Leu Gln Ala 
225                 230                 235                 240 


Glu Ser Lys Cys Ala Phe Leu Arg Ala Pro Leu Asn Ile Ile Asp Ile 
                245                 250                 255     


Leu Ala Leu Leu Pro Phe Tyr Val Ser Leu Leu Leu Gly Leu Ala Ala 
            260                 265                 270         


Gly Pro Gly Gly Thr Lys Leu Leu Glu Arg Ala Gly Leu Val Leu Arg 
        275                 280                 285             


Leu Leu Arg Ala Leu Arg Val Leu Tyr Val Met Arg Leu Ala Arg His 
    290                 295                 300                 


Ser Leu Gly Leu Arg Ser Leu Gly Leu Thr Met Arg Arg Cys Ala Arg 
305                 310                 315                 320 


Glu Phe Gly Leu Leu Leu Leu Phe Leu Cys Val Ala Met Ala Leu Phe 
                325                 330                 335     


Ala Pro Leu Val His Leu Ala Glu Arg Glu Leu Gly Ala Arg Arg Asp 
            340                 345                 350         


Phe Ser Ser Val Pro Ala Ser Tyr Trp Trp Ala Val Ile Ser Met Thr 
        355                 360                 365             


Thr Val Gly Tyr Gly Asp Met Val Pro Arg Ser Leu Pro Gly Gln Val 
    370                 375                 380                 


Val Ala Leu Ser Ser Ile Leu Ser Gly Ile Leu Leu Met Ala Phe Pro 
385                 390                 395                 400 


Val Thr Ser Ile Phe His Thr Phe Ser Arg Ser Tyr Ser Glu Leu Lys 
                405                 410                 415     


Glu Gln Gln Gln Arg Ala Ala Ser Pro Glu Pro Ala Leu Gln Glu Asp 
            420                 425                 430         


Ser Thr His Ser Ala Thr Ala Thr Glu Asp Ser Ser Gln Gly Pro Asp 
        435                 440                 445             


Ser Ala Gly Leu Ala Asp Asp Ser Ala Asp Ala Leu Trp Val Arg Ala 
    450                 455                 460                 


Gly Arg 
465     


<210>  3736
<211>  1083
<212>  PRT
<213>  Homo sapiens

<400>  3736

Met Pro Ala Met Arg Gly Leu Leu Ala Pro Gln Asn Thr Phe Leu Asp 
1               5                   10                  15      


Thr Ile Ala Thr Arg Phe Asp Gly Thr His Ser Asn Phe Val Leu Gly 
            20                  25                  30          


Asn Ala Gln Val Ala Gly Leu Phe Pro Val Val Tyr Cys Ser Asp Gly 
        35                  40                  45              


Phe Cys Asp Leu Thr Gly Phe Ser Arg Ala Glu Val Met Gln Arg Gly 
    50                  55                  60                  


Cys Ala Cys Ser Phe Leu Tyr Gly Pro Asp Thr Ser Glu Leu Val Arg 
65                  70                  75                  80  


Gln Gln Ile Arg Lys Ala Leu Asp Glu His Lys Glu Phe Lys Ala Glu 
                85                  90                  95      


Leu Ile Leu Tyr Arg Lys Ser Gly Leu Pro Phe Trp Cys Leu Leu Asp 
            100                 105                 110         


Val Ile Pro Ile Lys Asn Glu Lys Gly Glu Val Ala Leu Phe Leu Val 
        115                 120                 125             


Ser His Lys Asp Ile Ser Glu Thr Lys Asn Arg Gly Gly Pro Asp Arg 
    130                 135                 140                 


Trp Lys Glu Thr Gly Gly Gly Arg Arg Arg Tyr Gly Arg Ala Arg Ser 
145                 150                 155                 160 


Lys Gly Phe Asn Ala Asn Arg Arg Arg Ser Arg Ala Val Leu Tyr His 
                165                 170                 175     


Leu Ser Gly His Leu Gln Lys Gln Pro Lys Gly Lys His Lys Leu Asn 
            180                 185                 190         


Lys Gly Val Phe Gly Glu Lys Pro Asn Leu Pro Glu Tyr Lys Val Ala 
        195                 200                 205             


Ala Ile Arg Lys Ser Pro Phe Ile Leu Leu His Cys Gly Ala Leu Arg 
    210                 215                 220                 


Ala Thr Trp Asp Gly Phe Ile Leu Leu Ala Thr Leu Tyr Val Ala Val 
225                 230                 235                 240 


Thr Val Pro Tyr Ser Val Cys Val Ser Thr Ala Arg Glu Pro Ser Ala 
                245                 250                 255     


Ala Arg Gly Pro Pro Ser Val Cys Asp Leu Ala Val Glu Val Leu Phe 
            260                 265                 270         


Ile Leu Asp Ile Val Leu Asn Phe Arg Thr Thr Phe Val Ser Lys Ser 
        275                 280                 285             


Gly Gln Val Val Phe Ala Pro Lys Ser Ile Cys Leu His Tyr Val Thr 
    290                 295                 300                 


Thr Trp Phe Leu Leu Asp Val Ile Ala Ala Leu Pro Phe Asp Leu Leu 
305                 310                 315                 320 


His Ala Phe Lys Val Asn Val Tyr Phe Gly Ala His Leu Leu Lys Thr 
                325                 330                 335     


Val Arg Leu Leu Arg Leu Leu Arg Leu Leu Pro Arg Leu Asp Arg Tyr 
            340                 345                 350         


Ser Gln Tyr Ser Ala Val Val Leu Thr Leu Leu Met Ala Val Phe Ala 
        355                 360                 365             


Leu Leu Ala His Trp Val Ala Cys Val Trp Phe Tyr Ile Gly Gln Arg 
    370                 375                 380                 


Glu Ile Glu Ser Ser Glu Ser Glu Leu Pro Glu Ile Gly Trp Leu Gln 
385                 390                 395                 400 


Glu Leu Ala Arg Arg Leu Glu Thr Pro Tyr Tyr Leu Val Gly Arg Arg 
                405                 410                 415     


Pro Ala Gly Gly Asn Ser Ser Gly Gln Ser Asp Asn Cys Ser Ser Ser 
            420                 425                 430         


Ser Glu Ala Asn Gly Thr Gly Leu Glu Leu Leu Gly Gly Pro Ser Leu 
        435                 440                 445             


Arg Ser Ala Tyr Ile Thr Ser Leu Tyr Phe Ala Leu Ser Ser Leu Thr 
    450                 455                 460                 


Ser Val Gly Phe Gly Asn Val Ser Ala Asn Thr Asp Thr Glu Lys Ile 
465                 470                 475                 480 


Phe Ser Ile Cys Thr Met Leu Ile Gly Ala Leu Met His Ala Val Val 
                485                 490                 495     


Phe Gly Asn Val Thr Ala Ile Ile Gln Arg Met Tyr Ala Arg Arg Phe 
            500                 505                 510         


Leu Tyr His Ser Arg Thr Arg Asp Leu Arg Asp Tyr Ile Arg Ile His 
        515                 520                 525             


Arg Ile Pro Lys Pro Leu Lys Gln Arg Met Leu Glu Tyr Phe Gln Ala 
    530                 535                 540                 


Thr Trp Ala Val Asn Asn Gly Ile Asp Thr Thr Glu Leu Leu Gln Ser 
545                 550                 555                 560 


Leu Pro Asp Glu Leu Arg Ala Asp Ile Ala Met His Leu His Lys Glu 
                565                 570                 575     


Val Leu Gln Leu Pro Leu Phe Glu Ala Ala Ser Arg Gly Cys Leu Arg 
            580                 585                 590         


Ala Leu Ser Leu Ala Leu Arg Pro Ala Phe Cys Thr Pro Gly Glu Tyr 
        595                 600                 605             


Leu Ile His Gln Gly Asp Ala Leu Gln Ala Leu Tyr Phe Val Cys Ser 
    610                 615                 620                 


Gly Ser Met Glu Val Leu Lys Gly Gly Thr Val Leu Ala Ile Leu Gly 
625                 630                 635                 640 


Lys Gly Asp Leu Ile Gly Cys Glu Leu Pro Arg Arg Glu Gln Val Val 
                645                 650                 655     


Lys Ala Asn Ala Asp Val Lys Gly Leu Thr Tyr Cys Val Leu Gln Cys 
            660                 665                 670         


Leu Gln Leu Ala Gly Leu His Asp Ser Leu Ala Leu Tyr Pro Glu Phe 
        675                 680                 685             


Ala Pro Arg Phe Ser Arg Gly Leu Arg Gly Glu Leu Ser Tyr Asn Leu 
    690                 695                 700                 


Gly Ala Gly Gly Gly Ser Ala Glu Val Asp Thr Ser Ser Leu Ser Gly 
705                 710                 715                 720 


Asp Asn Thr Leu Met Ser Thr Leu Glu Glu Lys Glu Thr Asp Gly Glu 
                725                 730                 735     


Gln Gly Pro Thr Val Ser Pro Ala Pro Ala Asp Glu Pro Ser Ser Pro 
            740                 745                 750         


Leu Leu Ser Pro Gly Cys Thr Ser Ser Ser Ser Ala Ala Lys Leu Leu 
        755                 760                 765             


Ser Pro Arg Arg Thr Ala Pro Arg Pro Arg Leu Gly Gly Arg Gly Arg 
    770                 775                 780                 


Pro Gly Arg Ala Gly Ala Leu Lys Ala Glu Ala Gly Pro Ser Ala Pro 
785                 790                 795                 800 


Pro Arg Ala Leu Glu Gly Leu Arg Leu Pro Pro Met Pro Trp Asn Val 
                805                 810                 815     


Pro Pro Asp Leu Ser Pro Arg Val Val Asp Gly Ile Glu Asp Gly Cys 
            820                 825                 830         


Gly Ser Asp Gln Pro Lys Phe Ser Phe Arg Val Gly Gln Ser Gly Pro 
        835                 840                 845             


Glu Cys Ser Ser Ser Pro Ser Pro Gly Pro Glu Ser Gly Leu Leu Thr 
    850                 855                 860                 


Val Pro His Gly Pro Ser Glu Ala Arg Asn Thr Asp Thr Leu Asp Lys 
865                 870                 875                 880 


Leu Arg Gln Ala Val Thr Glu Leu Ser Glu Gln Val Leu Gln Met Arg 
                885                 890                 895     


Glu Gly Leu Gln Ser Leu Arg Gln Ala Val Gln Leu Val Leu Ala Pro 
            900                 905                 910         


His Arg Glu Gly Pro Cys Pro Arg Ala Ser Gly Glu Gly Pro Cys Pro 
        915                 920                 925             


Ala Ser Thr Ser Gly Leu Leu Gln Pro Leu Cys Val Asp Thr Gly Ala 
    930                 935                 940                 


Ser Ser Tyr Cys Leu Gln Pro Pro Ala Gly Ser Val Leu Ser Gly Thr 
945                 950                 955                 960 


Trp Pro His Pro Arg Pro Gly Pro Pro Pro Leu Met Ala Pro Trp Pro 
                965                 970                 975     


Trp Gly Pro Pro Ala Ser Gln Ser Ser Pro Trp Pro Arg Ala Thr Ala 
            980                 985                 990         


Phe Trp Thr Ser Thr Ser Asp Ser  Glu Pro Pro Ala Ser  Gly Asp Leu 
        995                 1000                 1005             


Cys Ser  Glu Pro Ser Thr Pro  Ala Ser Pro Pro Pro  Ser Glu Glu 
    1010                 1015                 1020             


Gly Ala  Arg Thr Gly Pro Ala  Glu Pro Val Ser Gln  Ala Glu Ala 
    1025                 1030                 1035             


Thr Ser  Thr Gly Glu Pro Pro  Pro Gly Ser Gly Gly  Leu Ala Leu 
    1040                 1045                 1050             


Pro Trp  Asp Pro His Ser Leu  Glu Met Val Leu Ile  Gly Cys His 
    1055                 1060                 1065             


Gly Ser  Gly Thr Val Gln Trp  Thr Gln Glu Glu Gly  Thr Gly Val 
    1070                 1075                 1080             


<210>  3737
<211>  1017
<212>  PRT
<213>  Homo sapiens

<400>  3737

Met Pro Val Met Lys Gly Leu Leu Ala Pro Gln Asn Thr Phe Leu Asp 
1               5                   10                  15      


Thr Ile Ala Thr Arg Phe Asp Gly Thr His Ser Asn Phe Leu Leu Ala 
            20                  25                  30          


Asn Ala Gln Gly Thr Arg Gly Phe Pro Ile Val Tyr Cys Ser Asp Gly 
        35                  40                  45              


Phe Cys Glu Leu Thr Gly Tyr Gly Arg Thr Glu Val Met Gln Lys Thr 
    50                  55                  60                  


Cys Ser Cys Arg Phe Leu Tyr Gly Pro Glu Thr Ser Glu Pro Ala Leu 
65                  70                  75                  80  


Gln Arg Leu His Lys Ala Leu Glu Gly His Gln Glu His Arg Ala Glu 
                85                  90                  95      


Ile Cys Phe Tyr Arg Lys Asp Gly Ser Ala Phe Trp Cys Leu Leu Asp 
            100                 105                 110         


Met Met Pro Ile Lys Asn Glu Met Gly Glu Val Val Leu Phe Leu Phe 
        115                 120                 125             


Ser Phe Lys Asp Ile Thr Gln Ser Gly Ser Pro Gly Leu Gly Pro Gln 
    130                 135                 140                 


Gly Gly Arg Gly Asp Ser Asn His Glu Asn Ser Leu Gly Arg Arg Gly 
145                 150                 155                 160 


Ala Thr Trp Lys Phe Arg Ser Ala Arg Arg Arg Ser Arg Thr Val Leu 
                165                 170                 175     


His Arg Leu Thr Gly His Phe Gly Arg Arg Gly Gln Gly Gly Met Lys 
            180                 185                 190         


Ala Asn Asn Asn Val Phe Glu Pro Lys Pro Ser Val Pro Glu Tyr Lys 
        195                 200                 205             


Val Ala Ser Val Gly Gly Ser Arg Cys Leu Leu Leu His Tyr Ser Val 
    210                 215                 220                 


Ser Lys Ala Ile Trp Asp Gly Leu Ile Leu Leu Ala Thr Phe Tyr Val 
225                 230                 235                 240 


Ala Val Thr Val Pro Tyr Asn Val Cys Phe Ser Gly Asp Asp Asp Thr 
                245                 250                 255     


Pro Ile Thr Ser Arg His Thr Leu Val Ser Asp Ile Ala Val Glu Met 
            260                 265                 270         


Leu Phe Ile Leu Asp Ile Ile Leu Asn Phe Arg Thr Thr Tyr Val Ser 
        275                 280                 285             


Gln Ser Gly Gln Val Ile Ser Ala Pro Arg Ser Ile Gly Leu His Tyr 
    290                 295                 300                 


Leu Ala Thr Trp Phe Phe Ile Asp Leu Ile Ala Ala Leu Pro Phe Asp 
305                 310                 315                 320 


Leu Leu Tyr Ile Phe Asn Ile Thr Val Thr Ser Leu Val His Leu Leu 
                325                 330                 335     


Lys Thr Val Arg Leu Leu Arg Leu Leu Arg Leu Leu Gln Lys Leu Glu 
            340                 345                 350         


Arg Tyr Ser Gln Cys Ser Ala Val Val Leu Thr Leu Leu Met Ser Val 
        355                 360                 365             


Phe Ala Leu Leu Ala His Trp Met Ala Cys Ile Trp Tyr Val Ile Gly 
    370                 375                 380                 


Arg Arg Glu Met Glu Ala Asn Asp Pro Leu Leu Trp Asp Ile Gly Trp 
385                 390                 395                 400 


Leu His Glu Leu Gly Lys Arg Leu Glu Val Pro Tyr Val Asn Gly Ser 
                405                 410                 415     


Val Gly Gly Pro Ser Arg Arg Ser Ala Tyr Ile Ala Ala Leu Tyr Phe 
            420                 425                 430         


Thr Leu Ser Ser Leu Thr Ser Val Gly Phe Gly Asn Val Cys Ala Asn 
        435                 440                 445             


Thr Asp Ala Glu Lys Ile Phe Ser Ile Cys Thr Met Leu Ile Gly Ala 
    450                 455                 460                 


Leu Met His Ala Val Val Phe Gly Asn Val Thr Ala Ile Ile Gln Arg 
465                 470                 475                 480 


Met Tyr Ser Arg Arg Ser Leu Tyr His Ser Arg Met Lys Asp Leu Lys 
                485                 490                 495     


Asp Phe Ile Arg Val His Arg Leu Pro Arg Pro Leu Lys Gln Arg Met 
            500                 505                 510         


Leu Glu Tyr Phe Gln Thr Thr Trp Ala Val Asn Ser Gly Ile Asp Ala 
        515                 520                 525             


Asn Glu Leu Leu Arg Asp Phe Pro Asp Glu Leu Arg Ala Asp Ile Ala 
    530                 535                 540                 


Met His Leu Asn Arg Glu Ile Leu Gln Leu Pro Leu Phe Gly Ala Ala 
545                 550                 555                 560 


Ser Arg Gly Cys Leu Arg Ala Leu Ser Leu His Ile Lys Thr Ser Phe 
                565                 570                 575     


Cys Ala Pro Gly Glu Tyr Leu Leu Arg Arg Gly Asp Ala Leu Gln Ala 
            580                 585                 590         


His Tyr Tyr Val Cys Ser Gly Ser Leu Glu Val Leu Arg Asp Asn Met 
        595                 600                 605             


Val Leu Ala Ile Leu Gly Lys Gly Asp Leu Ile Gly Ala Asp Ile Pro 
    610                 615                 620                 


Glu Pro Gly Gln Glu Pro Gly Leu Gly Ala Asp Pro Asn Phe Val Leu 
625                 630                 635                 640 


Lys Thr Ser Ala Asp Val Lys Ala Leu Thr Tyr Cys Gly Leu Gln Gln 
                645                 650                 655     


Leu Ser Ser Arg Gly Leu Ala Glu Val Leu Arg Leu Tyr Pro Glu Tyr 
            660                 665                 670         


Gly Ala Ala Phe Arg Ala Gly Leu Pro Arg Asp Leu Thr Phe Asn Leu 
        675                 680                 685             


Arg Gln Gly Ser Asp Thr Ser Gly Leu Ser Arg Phe Ser Arg Ser Pro 
    690                 695                 700                 


Arg Leu Ser Gln Pro Arg Ser Glu Ser Leu Gly Ser Ser Ser Asp Lys 
705                 710                 715                 720 


Thr Leu Pro Ser Ile Thr Glu Ala Glu Ser Gly Ala Glu Pro Gly Gly 
                725                 730                 735     


Gly Pro Arg Pro Arg Arg Pro Leu Leu Leu Pro Asn Leu Ser Pro Ala 
            740                 745                 750         


Arg Pro Arg Gly Ser Leu Val Ser Leu Leu Gly Glu Glu Leu Pro Pro 
        755                 760                 765             


Phe Ser Ala Leu Val Ser Ser Pro Ser Leu Ser Pro Ser Leu Ser Pro 
    770                 775                 780                 


Ala Leu Ala Gly Gln Gly His Ser Ala Ser Pro His Gly Pro Pro Arg 
785                 790                 795                 800 


Cys Ser Ala Ala Trp Lys Pro Pro Gln Leu Leu Ile Pro Pro Leu Gly 
                805                 810                 815     


Thr Phe Gly Pro Pro Asp Leu Ser Pro Arg Ile Val Asp Gly Ile Glu 
            820                 825                 830         


Asp Ser Gly Ser Thr Ala Glu Ala Pro Ser Phe Arg Phe Ser Arg Arg 
        835                 840                 845             


Pro Glu Leu Pro Arg Pro Arg Ser Gln Ala Pro Pro Thr Gly Thr Arg 
    850                 855                 860                 


Pro Ser Pro Glu Leu Ala Ser Glu Ala Glu Glu Val Lys Glu Lys Val 
865                 870                 875                 880 


Cys Arg Leu Asn Gln Glu Ile Ser Arg Leu Asn Gln Glu Val Ser Gln 
                885                 890                 895     


Leu Ser Arg Glu Leu Arg His Ile Met Gly Leu Leu Gln Ala Arg Leu 
            900                 905                 910         


Gly Pro Pro Gly His Pro Ala Gly Ser Ala Trp Thr Pro Asp Pro Pro 
        915                 920                 925             


Cys Pro Gln Leu Arg Pro Pro Cys Leu Ser Pro Cys Ala Ser Arg Pro 
    930                 935                 940                 


Pro Pro Ser Leu Gln Asp Thr Thr Leu Ala Glu Val His Cys Pro Ala 
945                 950                 955                 960 


Ser Val Gly Thr Met Glu Thr Gly Thr Ala Leu Leu Asp Leu Arg Pro 
                965                 970                 975     


Ser Ile Leu Pro Pro Tyr Pro Ser Glu Pro Asp Pro Leu Gly Pro Ser 
            980                 985                 990         


Pro Val Pro Glu Ala Ser Pro Pro  Thr Pro Ser Leu Leu  Arg His Ser 
        995                 1000                 1005             


Phe Gln  Ser Arg Ser Asp Thr  Phe His 
    1010                 1015         


<210>  3738
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  3738

Met Ala Phe Arg Arg Arg Thr Lys Ser Tyr Pro Leu Phe Ser Gln Glu 
1               5                   10                  15      


Phe Val Ile His Asn His Ala Asp Ile Gly Phe Cys Leu Val Leu Cys 
            20                  25                  30          


Val Leu Ile Gly Leu Met Phe Glu Val Thr Ala Lys Thr Ala Phe Leu 
        35                  40                  45              


Phe Ile Leu Pro Gln Tyr Asn Ile Ser Val Pro Thr Ala Asp Ser Glu 
    50                  55                  60                  


Thr Val His Tyr His Tyr Gly Pro Lys Asp Leu Val Thr Ile Leu Phe 
65                  70                  75                  80  


Tyr Ile Phe Ile Thr Ile Ile Leu His Ala Val Val Gln Glu Tyr Ile 
                85                  90                  95      


Leu Asp Lys Ile Ser Lys Arg Leu His Leu Ser Lys Val Lys His Ser 
            100                 105                 110         


Lys Phe Asn Glu Ser Gly Gln Leu Val Val Phe His Phe Thr Ser Val 
        115                 120                 125             


Ile Trp Cys Phe Tyr Val Val Val Thr Glu Gly Tyr Leu Thr Asn Pro 
    130                 135                 140                 


Arg Ser Leu Trp Glu Asp Tyr Pro His Val His Leu Pro Phe Gln Val 
145                 150                 155                 160 


Lys Phe Phe Tyr Leu Cys Gln Leu Ala Tyr Trp Leu His Ala Leu Pro 
                165                 170                 175     


Glu Leu Tyr Phe Gln Lys Val Arg Lys Glu Glu Ile Pro Arg Gln Leu 
            180                 185                 190         


Gln Tyr Ile Cys Leu Tyr Leu Val His Ile Ala Gly Ala Tyr Leu Leu 
        195                 200                 205             


Asn Leu Ser Arg Leu Gly Leu Ile Leu Leu Leu Leu Gln Tyr Ser Thr 
    210                 215                 220                 


Glu Phe Leu Phe His Thr Ala Arg Leu Phe Tyr Phe Ala Asp Glu Asn 
225                 230                 235                 240 


Asn Glu Lys Leu Phe Ser Ala Trp Ala Ala Val Phe Gly Val Thr Arg 
                245                 250                 255     


Leu Phe Ile Leu Thr Leu Ala Val Leu Ala Ile Gly Phe Gly Leu Ala 
            260                 265                 270         


Arg Met Glu Asn Gln Ala Phe Asp Pro Glu Lys Gly Asn Phe Asn Thr 
        275                 280                 285             


Leu Phe Cys Arg Leu Cys Val Leu Leu Leu Val Cys Ala Ala Gln Ala 
    290                 295                 300                 


Trp Leu Met Trp Arg Phe Ile His Ser Gln Leu Arg His Trp Arg Glu 
305                 310                 315                 320 


Tyr Trp Asn Glu Gln Ser Ala Lys Arg Arg Val Pro Ala Thr Pro Arg 
                325                 330                 335     


Leu Pro Ala Arg Leu Ile Lys Arg Glu Ser Gly Tyr His Glu Asn Gly 
            340                 345                 350         


Val Val Lys Ala Glu Asn Gly Thr Ser Pro Arg Thr Lys Lys Leu Lys 
        355                 360                 365             


Ser Pro 
    370 


<210>  3739
<211>  1479
<212>  PRT
<213>  Homo sapiens

<400>  3739

Met Ala Lys Arg Ser Arg Gly Pro Gly Arg Arg Cys Leu Leu Ala Leu 
1               5                   10                  15      


Val Leu Phe Cys Ala Trp Gly Thr Leu Ala Val Val Ala Gln Lys Pro 
            20                  25                  30          


Gly Ala Gly Cys Pro Ser Arg Cys Leu Cys Phe Arg Thr Thr Val Arg 
        35                  40                  45              


Cys Met His Leu Leu Leu Glu Ala Val Pro Ala Val Ala Pro Gln Thr 
    50                  55                  60                  


Ser Ile Leu Asp Leu Arg Phe Asn Arg Ile Arg Glu Ile Gln Pro Gly 
65                  70                  75                  80  


Ala Phe Arg Arg Leu Arg Asn Leu Asn Thr Leu Leu Leu Asn Asn Asn 
                85                  90                  95      


Gln Ile Lys Arg Ile Pro Ser Gly Ala Phe Glu Asp Leu Glu Asn Leu 
            100                 105                 110         


Lys Tyr Leu Tyr Leu Tyr Lys Asn Glu Ile Gln Ser Ile Asp Arg Gln 
        115                 120                 125             


Ala Phe Lys Gly Leu Ala Ser Leu Glu Gln Leu Tyr Leu His Phe Asn 
    130                 135                 140                 


Gln Ile Glu Thr Leu Asp Pro Asp Ser Phe Gln His Leu Pro Lys Leu 
145                 150                 155                 160 


Glu Arg Leu Phe Leu His Asn Asn Arg Ile Thr His Leu Val Pro Gly 
                165                 170                 175     


Thr Phe Asn His Leu Glu Ser Met Lys Arg Leu Arg Leu Asp Ser Asn 
            180                 185                 190         


Thr Leu His Cys Asp Cys Glu Ile Leu Trp Leu Ala Asp Leu Leu Lys 
        195                 200                 205             


Thr Tyr Ala Glu Ser Gly Asn Ala Gln Ala Ala Ala Ile Cys Glu Tyr 
    210                 215                 220                 


Pro Arg Arg Ile Gln Gly Arg Ser Val Ala Thr Ile Thr Pro Glu Glu 
225                 230                 235                 240 


Leu Asn Cys Glu Arg Pro Arg Ile Thr Ser Glu Pro Gln Asp Ala Asp 
                245                 250                 255     


Val Thr Ser Gly Asn Thr Val Tyr Phe Thr Cys Arg Ala Glu Gly Asn 
            260                 265                 270         


Pro Lys Pro Glu Ile Ile Trp Leu Arg Asn Asn Asn Glu Leu Ser Met 
        275                 280                 285             


Lys Thr Asp Ser Arg Leu Asn Leu Leu Asp Asp Gly Thr Leu Met Ile 
    290                 295                 300                 


Gln Asn Thr Gln Glu Thr Asp Gln Gly Ile Tyr Gln Cys Met Ala Lys 
305                 310                 315                 320 


Asn Val Ala Gly Glu Val Lys Thr Gln Glu Val Thr Leu Arg Tyr Phe 
                325                 330                 335     


Gly Ser Pro Ala Arg Pro Thr Phe Val Ile Gln Pro Gln Asn Thr Glu 
            340                 345                 350         


Val Leu Val Gly Glu Ser Val Thr Leu Glu Cys Ser Ala Thr Gly His 
        355                 360                 365             


Pro Pro Pro Arg Ile Ser Trp Thr Arg Gly Asp Arg Thr Pro Leu Pro 
    370                 375                 380                 


Val Asp Pro Arg Val Asn Ile Thr Pro Ser Gly Gly Leu Tyr Ile Gln 
385                 390                 395                 400 


Asn Val Val Gln Gly Asp Ser Gly Glu Tyr Ala Cys Ser Ala Thr Asn 
                405                 410                 415     


Asn Ile Asp Ser Val His Ala Thr Ala Phe Ile Ile Val Gln Ala Leu 
            420                 425                 430         


Pro Gln Phe Thr Val Thr Pro Gln Asp Arg Val Val Ile Glu Gly Gln 
        435                 440                 445             


Thr Val Asp Phe Gln Cys Glu Ala Lys Gly Asn Pro Pro Pro Val Ile 
    450                 455                 460                 


Ala Trp Thr Lys Gly Gly Ser Gln Leu Ser Val Asp Arg Arg His Leu 
465                 470                 475                 480 


Val Leu Ser Ser Gly Thr Leu Arg Ile Ser Gly Val Ala Leu His Asp 
                485                 490                 495     


Gln Gly Gln Tyr Glu Cys Gln Ala Val Asn Ile Ile Gly Ser Gln Lys 
            500                 505                 510         


Val Val Ala His Leu Thr Val Gln Pro Arg Val Thr Pro Val Phe Ala 
        515                 520                 525             


Ser Ile Pro Ser Asp Thr Thr Val Glu Val Gly Ala Asn Val Gln Leu 
    530                 535                 540                 


Pro Cys Ser Ser Gln Gly Glu Pro Glu Pro Ala Ile Thr Trp Asn Lys 
545                 550                 555                 560 


Asp Gly Val Gln Val Thr Glu Ser Gly Lys Phe His Ile Ser Pro Glu 
                565                 570                 575     


Gly Phe Leu Thr Ile Asn Asp Val Gly Pro Ala Asp Ala Gly Arg Tyr 
            580                 585                 590         


Glu Cys Val Ala Arg Asn Thr Ile Gly Ser Ala Ser Val Ser Met Val 
        595                 600                 605             


Leu Ser Val Asn Val Pro Asp Val Ser Arg Asn Gly Asp Pro Phe Val 
    610                 615                 620                 


Ala Thr Ser Ile Val Glu Ala Ile Ala Thr Val Asp Arg Ala Ile Asn 
625                 630                 635                 640 


Ser Thr Arg Thr His Leu Phe Asp Ser Arg Pro Arg Ser Pro Asn Asp 
                645                 650                 655     


Leu Leu Ala Leu Phe Arg Tyr Pro Arg Asp Pro Tyr Thr Val Glu Gln 
            660                 665                 670         


Ala Arg Ala Gly Glu Ile Phe Glu Arg Thr Leu Gln Leu Ile Gln Glu 
        675                 680                 685             


His Val Gln His Gly Leu Met Val Asp Leu Asn Gly Thr Ser Tyr His 
    690                 695                 700                 


Tyr Asn Asp Leu Val Ser Pro Gln Tyr Leu Asn Leu Ile Ala Asn Leu 
705                 710                 715                 720 


Ser Gly Cys Thr Ala His Arg Arg Val Asn Asn Cys Ser Asp Met Cys 
                725                 730                 735     


Phe His Gln Lys Tyr Arg Thr His Asp Gly Thr Cys Asn Asn Leu Gln 
            740                 745                 750         


His Pro Met Trp Gly Ala Ser Leu Thr Ala Phe Glu Arg Leu Leu Lys 
        755                 760                 765             


Ser Val Tyr Glu Asn Gly Phe Asn Thr Pro Arg Gly Ile Asn Pro His 
    770                 775                 780                 


Arg Leu Tyr Asn Gly His Ala Leu Pro Met Pro Arg Leu Val Ser Thr 
785                 790                 795                 800 


Thr Leu Ile Gly Thr Glu Thr Val Thr Pro Asp Glu Gln Phe Thr His 
                805                 810                 815     


Met Leu Met Gln Trp Gly Gln Phe Leu Asp His Asp Leu Asp Ser Thr 
            820                 825                 830         


Val Val Ala Leu Ser Gln Ala Arg Phe Ser Asp Gly Gln His Cys Ser 
        835                 840                 845             


Asn Val Cys Ser Asn Asp Pro Pro Cys Phe Ser Val Met Ile Pro Pro 
    850                 855                 860                 


Asn Asp Ser Arg Ala Arg Ser Gly Ala Arg Cys Met Phe Phe Val Arg 
865                 870                 875                 880 


Ser Ser Pro Val Cys Gly Ser Gly Met Thr Ser Leu Leu Met Asn Ser 
                885                 890                 895     


Val Tyr Pro Arg Glu Gln Ile Asn Gln Leu Thr Ser Tyr Ile Asp Ala 
            900                 905                 910         


Ser Asn Val Tyr Gly Ser Thr Glu His Glu Ala Arg Ser Ile Arg Asp 
        915                 920                 925             


Leu Ala Ser His Arg Gly Leu Leu Arg Gln Gly Ile Val Gln Arg Ser 
    930                 935                 940                 


Gly Lys Pro Leu Leu Pro Phe Ala Thr Gly Pro Pro Thr Glu Cys Met 
945                 950                 955                 960 


Arg Asp Glu Asn Glu Ser Pro Ile Pro Cys Phe Leu Ala Gly Asp His 
                965                 970                 975     


Arg Ala Asn Glu Gln Leu Gly Leu Thr Ser Met His Thr Leu Trp Phe 
            980                 985                 990         


Arg Glu His Asn Arg Ile Ala Thr  Glu Leu Leu Lys Leu  Asn Pro His 
        995                 1000                 1005             


Trp Asp  Gly Asp Thr Ile Tyr  Tyr Glu Thr Arg Lys  Ile Val Gly 
    1010                 1015                 1020             


Ala Glu  Ile Gln His Ile Thr  Tyr Gln His Trp Leu  Pro Lys Ile 
    1025                 1030                 1035             


Leu Gly  Glu Val Gly Met Arg  Thr Leu Gly Glu Tyr  His Gly Tyr 
    1040                 1045                 1050             


Asp Pro  Gly Ile Asn Ala Gly  Ile Phe Asn Ala Phe  Ala Thr Ala 
    1055                 1060                 1065             


Ala Phe  Arg Phe Gly His Thr  Leu Val Asn Pro Leu  Leu Tyr Arg 
    1070                 1075                 1080             


Leu Asp  Glu Asn Phe Gln Pro  Ile Ala Gln Asp His  Leu Pro Leu 
    1085                 1090                 1095             


His Lys  Ala Phe Phe Ser Pro  Phe Arg Ile Val Asn  Glu Gly Gly 
    1100                 1105                 1110             


Ile Asp  Pro Leu Leu Arg Gly  Leu Phe Gly Val Ala  Gly Lys Met 
    1115                 1120                 1125             


Arg Val  Pro Ser Gln Leu Leu  Asn Thr Glu Leu Thr  Glu Arg Leu 
    1130                 1135                 1140             


Phe Ser  Met Ala His Thr Val  Ala Leu Asp Leu Ala  Ala Ile Asn 
    1145                 1150                 1155             


Ile Gln  Arg Gly Arg Asp His  Gly Ile Pro Pro Tyr  His Asp Tyr 
    1160                 1165                 1170             


Arg Val  Tyr Cys Asn Leu Ser  Ala Ala His Thr Phe  Glu Asp Leu 
    1175                 1180                 1185             


Lys Asn  Glu Ile Lys Asn Pro  Glu Ile Arg Glu Lys  Leu Lys Arg 
    1190                 1195                 1200             


Leu Tyr  Gly Ser Thr Leu Asn  Ile Asp Leu Phe Pro  Ala Leu Val 
    1205                 1210                 1215             


Val Glu  Asp Leu Val Pro Gly  Ser Arg Leu Gly Pro  Thr Leu Met 
    1220                 1225                 1230             


Cys Leu  Leu Ser Thr Gln Phe  Lys Arg Leu Arg Asp  Gly Asp Arg 
    1235                 1240                 1245             


Leu Trp  Tyr Glu Asn Pro Gly  Val Phe Ser Pro Ala  Gln Leu Thr 
    1250                 1255                 1260             


Gln Ile  Lys Gln Thr Ser Leu  Ala Arg Ile Leu Cys  Asp Asn Ala 
    1265                 1270                 1275             


Asp Asn  Ile Thr Arg Val Gln  Ser Asp Val Phe Arg  Val Ala Glu 
    1280                 1285                 1290             


Phe Pro  His Gly Tyr Gly Ser  Cys Asp Glu Ile Pro  Arg Val Asp 
    1295                 1300                 1305             


Leu Arg  Val Trp Gln Asp Cys  Cys Glu Asp Cys Arg  Thr Arg Gly 
    1310                 1315                 1320             


Gln Phe  Asn Ala Phe Ser Tyr  His Phe Arg Gly Arg  Arg Ser Leu 
    1325                 1330                 1335             


Glu Phe  Ser Tyr Gln Glu Asp  Lys Pro Thr Lys Lys  Thr Arg Pro 
    1340                 1345                 1350             


Arg Lys  Ile Pro Ser Val Gly  Arg Gln Gly Glu His  Leu Ser Asn 
    1355                 1360                 1365             


Ser Thr  Ser Ala Phe Ser Thr  Arg Ser Asp Ala Ser  Gly Thr Asn 
    1370                 1375                 1380             


Asp Phe  Arg Glu Phe Val Leu  Glu Met Gln Lys Thr  Ile Thr Asp 
    1385                 1390                 1395             


Leu Arg  Thr Gln Ile Lys Lys  Leu Glu Ser Arg Leu  Ser Thr Thr 
    1400                 1405                 1410             


Glu Cys  Val Asp Ala Gly Gly  Glu Ser His Ala Asn  Asn Thr Lys 
    1415                 1420                 1425             


Trp Lys  Lys Asp Ala Cys Thr  Ile Cys Glu Cys Lys  Asp Gly Gln 
    1430                 1435                 1440             


Val Thr  Cys Phe Val Glu Ala  Cys Pro Pro Ala Thr  Cys Ala Val 
    1445                 1450                 1455             


Pro Val  Asn Ile Pro Gly Ala  Cys Cys Pro Val Cys  Leu Gln Lys 
    1460                 1465                 1470             


Arg Ala  Glu Glu Lys Pro 
    1475                 


<210>  3740
<211>  1403
<212>  PRT
<213>  Homo sapiens

<400>  3740

Met Val Ser Ser Gly Cys Arg Met Arg Ser Leu Trp Phe Ile Ile Val 
1               5                   10                  15      


Ile Ser Phe Leu Pro Asn Thr Glu Gly Phe Ser Arg Ala Ala Leu Pro 
            20                  25                  30          


Phe Gly Leu Val Arg Arg Glu Leu Ser Cys Glu Gly Tyr Ser Ile Asp 
        35                  40                  45              


Leu Arg Cys Pro Gly Ser Asp Val Ile Met Ile Glu Ser Ala Asn Tyr 
    50                  55                  60                  


Gly Arg Thr Asp Asp Lys Ile Cys Asp Ala Asp Pro Phe Gln Met Glu 
65                  70                  75                  80  


Asn Thr Asp Cys Tyr Leu Pro Asp Ala Phe Lys Ile Met Thr Gln Arg 
                85                  90                  95      


Cys Asn Asn Arg Thr Gln Cys Ile Val Val Thr Gly Ser Asp Val Phe 
            100                 105                 110         


Pro Asp Pro Cys Pro Gly Thr Tyr Lys Tyr Leu Glu Val Gln Tyr Glu 
        115                 120                 125             


Cys Val Pro Tyr Ile Phe Val Cys Pro Gly Thr Leu Lys Ala Ile Val 
    130                 135                 140                 


Asp Ser Pro Cys Ile Tyr Glu Ala Glu Gln Lys Ala Gly Ala Trp Cys 
145                 150                 155                 160 


Lys Asp Pro Leu Gln Ala Ala Asp Lys Ile Tyr Phe Met Pro Trp Thr 
                165                 170                 175     


Pro Tyr Arg Thr Asp Thr Leu Ile Glu Tyr Ala Ser Leu Glu Asp Phe 
            180                 185                 190         


Gln Asn Ser Arg Gln Thr Thr Thr Tyr Lys Leu Pro Asn Arg Val Asp 
        195                 200                 205             


Gly Thr Gly Phe Val Val Tyr Asp Gly Ala Val Phe Phe Asn Lys Glu 
    210                 215                 220                 


Arg Thr Arg Asn Ile Val Lys Phe Asp Leu Arg Thr Arg Ile Lys Ser 
225                 230                 235                 240 


Gly Glu Ala Ile Ile Asn Tyr Ala Asn Tyr His Asp Thr Ser Pro Tyr 
                245                 250                 255     


Arg Trp Gly Gly Lys Thr Asp Ile Asp Leu Ala Val Asp Glu Asn Gly 
            260                 265                 270         


Leu Trp Val Ile Tyr Ala Thr Glu Gln Asn Asn Gly Met Ile Val Ile 
        275                 280                 285             


Ser Gln Leu Asn Pro Tyr Thr Leu Arg Phe Glu Ala Thr Trp Glu Thr 
    290                 295                 300                 


Val Tyr Asp Lys Arg Ala Ala Ser Asn Ala Phe Met Ile Cys Gly Val 
305                 310                 315                 320 


Leu Tyr Val Val Arg Ser Val Tyr Gln Asp Asn Glu Ser Glu Thr Gly 
                325                 330                 335     


Lys Asn Ser Ile Asp Tyr Ile Tyr Asn Thr Arg Leu Asn Arg Gly Glu 
            340                 345                 350         


Tyr Val Asp Val Pro Phe Pro Asn Gln Tyr Gln Tyr Ile Ala Ala Val 
        355                 360                 365             


Asp Tyr Asn Pro Arg Asp Asn Gln Leu Tyr Val Trp Asn Asn Asn Phe 
    370                 375                 380                 


Ile Leu Arg Tyr Ser Leu Glu Phe Gly Pro Pro Asp Pro Ala Gln Val 
385                 390                 395                 400 


Pro Thr Thr Ala Val Thr Ile Thr Ser Ser Ala Glu Leu Phe Lys Thr 
                405                 410                 415     


Ile Ile Ser Thr Thr Ser Thr Thr Ser Gln Lys Gly Pro Met Ser Thr 
            420                 425                 430         


Thr Val Ala Gly Ser Gln Glu Gly Ser Lys Gly Thr Lys Pro Pro Pro 
        435                 440                 445             


Ala Val Ser Thr Thr Lys Ile Pro Pro Ile Thr Asn Ile Phe Pro Leu 
    450                 455                 460                 


Pro Glu Arg Phe Cys Glu Ala Leu Asp Ser Lys Gly Ile Lys Trp Pro 
465                 470                 475                 480 


Gln Thr Gln Arg Gly Met Met Val Glu Arg Pro Cys Pro Lys Gly Thr 
                485                 490                 495     


Arg Gly Thr Ala Ser Tyr Leu Cys Met Ile Ser Thr Gly Thr Trp Asn 
            500                 505                 510         


Pro Lys Gly Pro Asp Leu Ser Asn Cys Thr Ser His Trp Val Asn Gln 
        515                 520                 525             


Leu Ala Gln Lys Ile Arg Ser Gly Glu Asn Ala Ala Ser Leu Ala Asn 
    530                 535                 540                 


Glu Leu Ala Lys His Thr Lys Gly Pro Val Phe Ala Gly Asp Val Ser 
545                 550                 555                 560 


Ser Ser Val Arg Leu Met Glu Gln Leu Val Asp Ile Leu Asp Ala Gln 
                565                 570                 575     


Leu Gln Glu Leu Lys Pro Ser Glu Lys Asp Ser Ala Gly Arg Ser Tyr 
            580                 585                 590         


Asn Lys Ala Ile Val Asp Thr Val Asp Asn Leu Leu Arg Pro Glu Ala 
        595                 600                 605             


Leu Glu Ser Trp Lys His Met Asn Ser Ser Glu Gln Ala His Thr Ala 
    610                 615                 620                 


Thr Met Leu Leu Asp Thr Leu Glu Glu Gly Ala Phe Val Leu Ala Asp 
625                 630                 635                 640 


Asn Leu Leu Glu Pro Thr Arg Val Ser Met Pro Thr Glu Asn Ile Val 
                645                 650                 655     


Leu Glu Val Ala Val Leu Ser Thr Glu Gly Gln Ile Gln Asp Phe Lys 
            660                 665                 670         


Phe Pro Leu Gly Ile Lys Gly Ala Gly Ser Ser Ile Gln Leu Ser Ala 
        675                 680                 685             


Asn Thr Val Lys Gln Asn Ser Arg Asn Gly Leu Ala Lys Leu Val Phe 
    690                 695                 700                 


Ile Ile Tyr Arg Ser Leu Gly Gln Phe Leu Ser Thr Glu Asn Ala Thr 
705                 710                 715                 720 


Ile Lys Leu Gly Ala Asp Phe Ile Gly Arg Asn Ser Thr Ile Ala Val 
                725                 730                 735     


Asn Ser His Val Ile Ser Val Ser Ile Asn Lys Glu Ser Ser Arg Val 
            740                 745                 750         


Tyr Leu Thr Asp Pro Val Leu Phe Thr Leu Pro His Ile Asp Pro Asp 
        755                 760                 765             


Asn Tyr Phe Asn Ala Asn Cys Ser Phe Trp Asn Tyr Ser Glu Arg Thr 
    770                 775                 780                 


Met Met Gly Tyr Trp Ser Thr Gln Gly Cys Lys Leu Val Asp Thr Asn 
785                 790                 795                 800 


Lys Thr Arg Thr Thr Cys Ala Cys Ser His Leu Thr Asn Phe Ala Ile 
                805                 810                 815     


Leu Met Ala His Arg Glu Ile Ala Tyr Lys Asp Gly Val His Glu Leu 
            820                 825                 830         


Leu Leu Thr Val Ile Thr Trp Val Gly Ile Val Ile Ser Leu Val Cys 
        835                 840                 845             


Leu Ala Ile Cys Ile Phe Thr Phe Cys Phe Phe Arg Gly Leu Gln Ser 
    850                 855                 860                 


Asp Arg Asn Thr Ile His Lys Asn Leu Cys Ile Asn Leu Phe Ile Ala 
865                 870                 875                 880 


Glu Phe Ile Phe Leu Ile Gly Ile Asp Lys Thr Lys Tyr Ala Ile Ala 
                885                 890                 895     


Cys Pro Ile Phe Ala Gly Leu Leu His Phe Phe Phe Leu Ala Ala Phe 
            900                 905                 910         


Ala Trp Met Cys Leu Glu Gly Val Gln Leu Tyr Leu Met Leu Val Glu 
        915                 920                 925             


Val Phe Glu Ser Glu Tyr Ser Arg Lys Lys Tyr Tyr Tyr Val Ala Gly 
    930                 935                 940                 


Tyr Leu Phe Pro Ala Thr Val Val Gly Val Ser Ala Ala Ile Asp Tyr 
945                 950                 955                 960 


Lys Ser Tyr Gly Thr Glu Lys Ala Cys Trp Leu His Val Asp Asn Tyr 
                965                 970                 975     


Phe Ile Trp Ser Phe Ile Gly Pro Val Thr Phe Ile Ile Leu Leu Asn 
            980                 985                 990         


Ile Ile Phe Leu Val Ile Thr Leu  Cys Lys Met Val Lys  His Ser Asn 
        995                 1000                 1005             


Thr Leu  Lys Pro Asp Ser Ser  Arg Leu Glu Asn Ile  Lys Ser Trp 
    1010                 1015                 1020             


Val Leu  Gly Ala Phe Ala Leu  Leu Cys Leu Leu Gly  Leu Thr Trp 
    1025                 1030                 1035             


Ser Phe  Gly Leu Leu Phe Ile  Asn Glu Glu Thr Ile  Val Met Ala 
    1040                 1045                 1050             


Tyr Leu  Phe Thr Ile Phe Asn  Ala Phe Gln Gly Val  Phe Ile Phe 
    1055                 1060                 1065             


Ile Phe  His Cys Ala Leu Gln  Lys Lys Val Arg Lys  Glu Tyr Gly 
    1070                 1075                 1080             


Lys Cys  Phe Arg His Ser Tyr  Cys Cys Gly Gly Leu  Pro Thr Glu 
    1085                 1090                 1095             


Ser Pro  His Ser Ser Val Lys  Ala Ser Thr Thr Arg  Thr Ser Ala 
    1100                 1105                 1110             


Arg Tyr  Ser Ser Gly Thr Gln  Ser Arg Ile Arg Arg  Met Trp Asn 
    1115                 1120                 1125             


Asp Thr  Val Arg Lys Gln Ser  Glu Ser Ser Phe Ile  Ser Gly Asp 
    1130                 1135                 1140             


Ile Asn  Ser Thr Ser Thr Leu  Asn Gln Gly His Ser  Leu Asn Asn 
    1145                 1150                 1155             


Ala Arg  Asp Thr Ser Ala Met  Asp Thr Leu Pro Leu  Asn Gly Asn 
    1160                 1165                 1170             


Phe Asn  Asn Ser Tyr Ser Leu  His Lys Gly Asp Tyr  Asn Asp Ser 
    1175                 1180                 1185             


Val Gln  Val Val Asp Cys Gly  Leu Ser Leu Asn Asp  Thr Ala Phe 
    1190                 1195                 1200             


Glu Lys  Met Ile Ile Ser Glu  Leu Val His Asn Asn  Leu Arg Gly 
    1205                 1210                 1215             


Ser Ser  Lys Thr His Asn Leu  Glu Leu Thr Leu Pro  Val Lys Pro 
    1220                 1225                 1230             


Val Ile  Gly Gly Ser Ser Ser  Glu Asp Asp Ala Ile  Val Ala Asp 
    1235                 1240                 1245             


Ala Ser  Ser Leu Met His Ser  Asp Asn Pro Gly Leu  Glu Leu His 
    1250                 1255                 1260             


His Lys  Glu Leu Glu Ala Pro  Leu Ile Pro Gln Arg  Thr His Ser 
    1265                 1270                 1275             


Leu Leu  Tyr Gln Pro Gln Lys  Lys Val Lys Ser Glu  Gly Thr Asp 
    1280                 1285                 1290             


Ser Tyr  Val Ser Gln Leu Thr  Ala Glu Ala Glu Asp  His Leu Gln 
    1295                 1300                 1305             


Ser Pro  Asn Arg Asp Ser Leu  Tyr Thr Ser Met Pro  Asn Leu Arg 
    1310                 1315                 1320             


Asp Ser  Pro Tyr Pro Glu Ser  Ser Pro Asp Met Glu  Glu Asp Leu 
    1325                 1330                 1335             


Ser Pro  Ser Arg Arg Ser Glu  Asn Glu Asp Ile Tyr  Tyr Lys Ser 
    1340                 1345                 1350             


Met Pro  Asn Leu Gly Ala Gly  His Gln Leu Gln Met  Cys Tyr Gln 
    1355                 1360                 1365             


Ile Ser  Arg Gly Asn Ser Asp  Gly Tyr Ile Ile Pro  Ile Asn Lys 
    1370                 1375                 1380             


Glu Gly  Cys Ile Pro Glu Gly  Asp Val Arg Glu Gly  Gln Met Gln 
    1385                 1390                 1395             


Leu Val  Thr Ser Leu 
    1400             


<210>  3741
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  3741

Met Thr Gln Gly Lys Leu Ser Val Ala Asn Lys Ala Pro Gly Thr Glu 
1               5                   10                  15      


Gly Gln Gln Gln Val His Gly Glu Lys Lys Glu Ala Pro Ala Val Pro 
            20                  25                  30          


Ser Ala Pro Pro Ser Tyr Glu Glu Ala Thr Ser Gly Glu Gly Met Lys 
        35                  40                  45              


Ala Gly Ala Phe Pro Pro Ala Pro Thr Ala Val Pro Leu His Pro Ser 
    50                  55                  60                  


Trp Ala Tyr Val Asp Pro Ser Ser Ser Ser Ser Tyr Asp Asn Gly Phe 
65                  70                  75                  80  


Pro Thr Gly Asp His Glu Leu Phe Thr Thr Phe Ser Trp Asp Asp Gln 
                85                  90                  95      


Lys Val Arg Arg Val Phe Val Arg Lys Val Tyr Thr Ile Leu Leu Ile 
            100                 105                 110         


Gln Leu Leu Val Thr Leu Ala Val Val Ala Leu Phe Thr Phe Cys Asp 
        115                 120                 125             


Pro Val Lys Asp Tyr Val Gln Ala Asn Pro Gly Trp Tyr Trp Ala Ser 
    130                 135                 140                 


Tyr Ala Val Phe Phe Ala Thr Tyr Leu Thr Leu Ala Cys Cys Ser Gly 
145                 150                 155                 160 


Pro Arg Arg His Phe Pro Trp Asn Leu Ile Leu Leu Thr Val Phe Thr 
                165                 170                 175     


Leu Ser Met Ala Tyr Leu Thr Gly Met Leu Ser Ser Tyr Tyr Asn Thr 
            180                 185                 190         


Thr Ser Val Leu Leu Cys Leu Gly Ile Thr Ala Leu Val Cys Leu Ser 
        195                 200                 205             


Val Thr Val Phe Ser Phe Gln Thr Lys Phe Asp Phe Thr Ser Cys Gln 
    210                 215                 220                 


Gly Val Leu Phe Val Leu Leu Met Thr Leu Phe Phe Ser Gly Leu Ile 
225                 230                 235                 240 


Leu Ala Ile Leu Leu Pro Phe Gln Tyr Val Pro Trp Leu His Ala Val 
                245                 250                 255     


Tyr Ala Ala Leu Gly Ala Gly Val Phe Thr Leu Phe Leu Ala Leu Asp 
            260                 265                 270         


Thr Gln Leu Leu Met Gly Asn Arg Arg His Ser Leu Ser Pro Glu Glu 
        275                 280                 285             


Tyr Ile Phe Gly Ala Leu Asn Ile Tyr Leu Asp Ile Ile Tyr Ile Phe 
    290                 295                 300                 


Thr Phe Phe Leu Gln Leu Phe Gly Thr Asn Arg Glu 
305                 310                 315     


<210>  3742
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  3742

Met Ser Leu Met Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro His Glu Gly Val His Arg Lys Pro Ser Leu Leu 
            20                  25                  30          


Ala His Pro Gly Pro Leu Val Lys Ser Glu Glu Thr Val Ile Leu Gln 
        35                  40                  45              


Cys Trp Ser Asp Val Arg Phe Glu His Phe Leu Leu His Arg Glu Gly 
    50                  55                  60                  


Lys Tyr Lys Asp Thr Leu His Leu Ile Gly Glu His His Asp Gly Val 
65                  70                  75                  80  


Ser Lys Ala Asn Phe Ser Ile Gly Pro Met Met Gln Asp Leu Ala Gly 
                85                  90                  95      


Thr Tyr Arg Cys Tyr Gly Ser Val Thr His Ser Pro Tyr Gln Leu Ser 
            100                 105                 110         


Ala Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys 
        115                 120                 125             


Pro Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Leu Ala Gly Glu Ser 
    130                 135                 140                 


Val Thr Leu Ser Cys Ser Ser Arg Ser Ser Tyr Asp Met Tyr His Leu 
145                 150                 155                 160 


Ser Arg Glu Gly Glu Ala His Glu Arg Arg Phe Ser Ala Gly Pro Lys 
                165                 170                 175     


Val Asn Gly Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His 
            180                 185                 190         


Gly Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Asp Ser Pro Tyr Glu 
        195                 200                 205             


Trp Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro 
    210                 215                 220                 


Ser Asn Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Thr Gly Asn 
225                 230                 235                 240 


Pro Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Lys Ile Pro 
                245                 250                 255     


Phe Thr Ile Leu Leu Phe Phe Leu Leu His Arg Trp Cys Ser Asn Lys 
            260                 265                 270         


Lys Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asn Arg Thr Val 
        275                 280                 285             


Asn Ser Glu Asp Ser Asp Glu Gln Asp His Gln Glu Val Ser Tyr Ala 
    290                 295                 300                 


<210>  3743
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  3743

Met Ser Leu Met Val Ile Ile Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro Gln Glu Gly Val His Arg Lys Pro Ser Phe Leu 
            20                  25                  30          


Ala Leu Pro Gly His Leu Val Lys Ser Glu Glu Thr Val Ile Leu Gln 
        35                  40                  45              


Cys Trp Ser Asp Val Met Phe Glu His Phe Leu Leu His Arg Glu Gly 
    50                  55                  60                  


Lys Phe Asn Asn Thr Leu His Leu Ile Gly Glu His His Asp Gly Val 
65                  70                  75                  80  


Ser Lys Ala Asn Phe Ser Ile Gly Pro Met Met Pro Val Leu Ala Gly 
                85                  90                  95      


Thr Tyr Arg Cys Tyr Gly Ser Val Pro His Ser Pro Tyr Gln Leu Ser 
            100                 105                 110         


Ala Pro Ser Asp Pro Leu Asp Met Val Ile Ile Gly Leu Tyr Glu Lys 
        115                 120                 125             


Pro Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Gln Ala Gly Glu Asn 
    130                 135                 140                 


Val Thr Leu Ser Cys Ser Ser Arg Ser Ser Tyr Asp Met Tyr His Leu 
145                 150                 155                 160 


Ser Arg Glu Gly Glu Ala His Glu Arg Arg Leu Pro Ala Val Arg Ser 
                165                 170                 175     


Ile Asn Gly Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His 
            180                 185                 190         


Gly Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Asp Ala Pro Tyr Glu 
        195                 200                 205             


Trp Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro 
    210                 215                 220                 


Ser Asn Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Thr Gly Asn 
225                 230                 235                 240 


Pro Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Lys Ile Pro 
                245                 250                 255     


Phe Thr Ile Leu Leu Phe Phe Leu Leu His Arg Trp Cys Ser Asp Lys 
            260                 265                 270         


Lys Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asn Arg Thr Val 
        275                 280                 285             


Asn Ser Glu Asp Ser Asp Glu Gln Asp His Gln Glu Val Ser Tyr Ala 
    290                 295                 300                 


<210>  3744
<211>  739
<212>  PRT
<213>  Homo sapiens

<400>  3744

Met Ala Ser Ile Leu Leu Arg Ser Cys Arg Gly Arg Ala Pro Ala Arg 
1               5                   10                  15      


Leu Pro Pro Pro Pro Arg Tyr Thr Val Pro Arg Gly Ser Pro Gly Asp 
            20                  25                  30          


Pro Ala His Leu Ser Cys Ala Ser Thr Leu Gly Leu Arg Asn Cys Leu 
        35                  40                  45              


Asn Val Pro Phe Gly Cys Cys Thr Pro Ile His Pro Val Tyr Thr Ser 
    50                  55                  60                  


Ser Arg Gly Asp His Leu Gly Cys Trp Ala Leu Arg Pro Glu Cys Leu 
65                  70                  75                  80  


Arg Ile Val Ser Arg Ala Pro Trp Thr Ser Thr Ser Val Gly Phe Val 
                85                  90                  95      


Ala Val Gly Pro Gln Cys Leu Pro Val Arg Gly Trp His Ser Ser Arg 
            100                 105                 110         


Pro Val Arg Asp Asp Ser Val Val Glu Lys Ser Leu Lys Ser Leu Lys 
        115                 120                 125             


Asp Lys Asn Lys Lys Leu Glu Glu Gly Gly Pro Val Tyr Ser Pro Pro 
    130                 135                 140                 


Ala Glu Val Val Val Lys Lys Ser Leu Gly Gln Arg Val Leu Asp Glu 
145                 150                 155                 160 


Leu Lys His Tyr Tyr His Gly Phe Arg Leu Leu Trp Ile Asp Thr Lys 
                165                 170                 175     


Ile Ala Ala Arg Met Leu Trp Arg Ile Leu Asn Gly His Ser Leu Thr 
            180                 185                 190         


Arg Arg Glu Arg Arg Gln Phe Leu Arg Ile Cys Ala Asp Leu Phe Arg 
        195                 200                 205             


Leu Val Pro Phe Leu Val Phe Val Val Val Pro Phe Met Glu Phe Leu 
    210                 215                 220                 


Leu Pro Val Ala Val Lys Leu Phe Pro Asn Met Leu Pro Ser Thr Phe 
225                 230                 235                 240 


Glu Thr Gln Ser Leu Lys Glu Glu Arg Leu Lys Lys Glu Leu Arg Val 
                245                 250                 255     


Lys Leu Glu Leu Ala Lys Phe Leu Gln Asp Thr Ile Glu Glu Met Ala 
            260                 265                 270         


Leu Lys Asn Lys Ala Ala Lys Gly Ser Ala Thr Lys Asp Phe Ser Val 
        275                 280                 285             


Phe Phe Gln Lys Ile Arg Glu Thr Gly Glu Arg Pro Ser Asn Glu Glu 
    290                 295                 300                 


Ile Met Arg Phe Ser Lys Leu Phe Glu Asp Glu Leu Thr Leu Asp Asn 
305                 310                 315                 320 


Leu Thr Arg Pro Gln Leu Val Ala Leu Cys Lys Leu Leu Glu Leu Gln 
                325                 330                 335     


Ser Ile Gly Thr Asn Asn Phe Leu Arg Phe Gln Leu Thr Met Arg Leu 
            340                 345                 350         


Arg Ser Ile Lys Ala Asp Asp Lys Leu Ile Ala Glu Glu Gly Val Asp 
        355                 360                 365             


Ser Leu Asn Val Lys Glu Leu Gln Ala Ala Cys Arg Ala Arg Gly Met 
    370                 375                 380                 


Arg Ala Leu Gly Val Thr Glu Asp Arg Leu Arg Gly Gln Leu Lys Gln 
385                 390                 395                 400 


Trp Leu Asp Leu His Leu His Gln Glu Ile Pro Thr Ser Leu Leu Ile 
                405                 410                 415     


Leu Ser Arg Ala Met Tyr Leu Pro Asp Thr Leu Ser Pro Ala Asp Gln 
            420                 425                 430         


Leu Lys Ser Thr Leu Gln Thr Leu Pro Glu Ile Val Ala Lys Glu Ala 
        435                 440                 445             


Gln Val Lys Val Ala Glu Val Glu Gly Glu Gln Val Asp Asn Lys Ala 
    450                 455                 460                 


Lys Leu Glu Ala Thr Leu Gln Glu Glu Ala Ala Ile Gln Gln Glu His 
465                 470                 475                 480 


Arg Glu Lys Glu Leu Gln Lys Arg Ser Glu Val Ala Lys Asp Phe Glu 
                485                 490                 495     


Pro Glu Arg Val Val Ala Ala Pro Gln Arg Pro Gly Thr Glu Pro Gln 
            500                 505                 510         


Pro Glu Met Pro Asp Thr Val Leu Gln Ser Glu Thr Leu Lys Asp Thr 
        515                 520                 525             


Ala Pro Val Leu Glu Gly Leu Lys Glu Glu Glu Ile Thr Lys Glu Glu 
    530                 535                 540                 


Ile Asp Ile Leu Ser Asp Ala Cys Ser Lys Leu Gln Glu Gln Lys Lys 
545                 550                 555                 560 


Ser Leu Thr Lys Glu Lys Glu Glu Leu Glu Leu Leu Lys Glu Asp Val 
                565                 570                 575     


Gln Asp Tyr Ser Glu Asp Leu Gln Glu Ile Lys Lys Glu Leu Ser Lys 
            580                 585                 590         


Thr Gly Glu Glu Lys Tyr Val Glu Glu Ser Lys Ala Ser Lys Arg Leu 
        595                 600                 605             


Thr Lys Arg Val Gln Gln Met Ile Gly Gln Ile Asp Gly Leu Ile Ser 
    610                 615                 620                 


Gln Leu Glu Met Asp Gln Gln Ala Gly Lys Leu Ala Pro Ala Asn Gly 
625                 630                 635                 640 


Met Pro Thr Gly Glu Asn Val Ile Ser Val Ala Glu Leu Ile Asn Ala 
                645                 650                 655     


Met Lys Gln Val Lys His Ile Pro Glu Ser Lys Leu Thr Ser Leu Ala 
            660                 665                 670         


Ala Ala Leu Asp Glu Asn Lys Asp Gly Lys Val Asn Ile Asp Asp Leu 
        675                 680                 685             


Val Lys Val Ile Glu Leu Val Asp Lys Glu Asp Val His Ile Ser Thr 
    690                 695                 700                 


Ser Gln Val Ala Glu Ile Val Ala Thr Leu Glu Lys Glu Glu Lys Val 
705                 710                 715                 720 


Glu Glu Lys Glu Lys Ala Lys Glu Lys Ala Glu Lys Glu Val Ala Glu 
                725                 730                 735     


Val Lys Ser 
            


<210>  3745
<211>  755
<212>  PRT
<213>  Homo sapiens

<400>  3745

Met Ala Arg Lys Leu Ser Val Ile Leu Ile Leu Thr Phe Ala Leu Ser 
1               5                   10                  15      


Val Thr Asn Pro Leu His Glu Leu Lys Ala Ala Ala Phe Pro Gln Thr 
            20                  25                  30          


Thr Glu Lys Ile Ser Pro Asn Trp Glu Ser Gly Ile Asn Val Asp Leu 
        35                  40                  45              


Ala Ile Ser Thr Arg Gln Tyr His Leu Gln Gln Leu Phe Tyr Arg Tyr 
    50                  55                  60                  


Gly Glu Asn Asn Ser Leu Ser Val Glu Gly Phe Arg Lys Leu Leu Gln 
65                  70                  75                  80  


Asn Ile Gly Ile Asp Lys Ile Lys Arg Ile His Ile His His Asp His 
                85                  90                  95      


Asp His His Ser Asp His Glu His His Ser Asp His Glu Arg His Ser 
            100                 105                 110         


Asp His Glu His His Ser Asp His Glu His His Ser Asp His Asp His 
        115                 120                 125             


His Ser His His Asn His Ala Ala Ser Gly Lys Asn Lys Arg Lys Ala 
    130                 135                 140                 


Leu Cys Pro Asp His Asp Ser Asp Ser Ser Gly Lys Asp Pro Arg Asn 
145                 150                 155                 160 


Ser Gln Gly Lys Gly Ala His Arg Pro Glu His Ala Ser Gly Arg Arg 
                165                 170                 175     


Asn Val Lys Asp Ser Val Ser Ala Ser Glu Val Thr Ser Thr Val Tyr 
            180                 185                 190         


Asn Thr Val Ser Glu Gly Thr His Phe Leu Glu Thr Ile Glu Thr Pro 
        195                 200                 205             


Arg Pro Gly Lys Leu Phe Pro Lys Asp Val Ser Ser Ser Thr Pro Pro 
    210                 215                 220                 


Ser Val Thr Ser Lys Ser Arg Val Ser Arg Leu Ala Gly Arg Lys Thr 
225                 230                 235                 240 


Asn Glu Ser Val Ser Glu Pro Arg Lys Gly Phe Met Tyr Ser Arg Asn 
                245                 250                 255     


Thr Asn Glu Asn Pro Gln Glu Cys Phe Asn Ala Ser Lys Leu Leu Thr 
            260                 265                 270         


Ser His Gly Met Gly Ile Gln Val Pro Leu Asn Ala Thr Glu Phe Asn 
        275                 280                 285             


Tyr Leu Cys Pro Ala Ile Ile Asn Gln Ile Asp Ala Arg Ser Cys Leu 
    290                 295                 300                 


Ile His Thr Ser Glu Lys Lys Ala Glu Ile Pro Pro Lys Thr Tyr Ser 
305                 310                 315                 320 


Leu Gln Ile Ala Trp Val Gly Gly Phe Ile Ala Ile Ser Ile Ile Ser 
                325                 330                 335     


Phe Leu Ser Leu Leu Gly Val Ile Leu Val Pro Leu Met Asn Arg Val 
            340                 345                 350         


Phe Phe Lys Phe Leu Leu Ser Phe Leu Val Ala Leu Ala Val Gly Thr 
        355                 360                 365             


Leu Ser Gly Asp Ala Phe Leu His Leu Leu Pro His Ser His Ala Ser 
    370                 375                 380                 


His His His Ser His Ser His Glu Glu Pro Ala Met Glu Met Lys Arg 
385                 390                 395                 400 


Gly Pro Leu Phe Ser His Leu Ser Ser Gln Asn Ile Glu Glu Ser Ala 
                405                 410                 415     


Tyr Phe Asp Ser Thr Trp Lys Gly Leu Thr Ala Leu Gly Gly Leu Tyr 
            420                 425                 430         


Phe Met Phe Leu Val Glu His Val Leu Thr Leu Ile Lys Gln Phe Lys 
        435                 440                 445             


Asp Lys Lys Lys Lys Asn Gln Lys Lys Pro Glu Asn Asp Asp Asp Val 
    450                 455                 460                 


Glu Ile Lys Lys Gln Leu Ser Lys Tyr Glu Ser Gln Leu Ser Thr Asn 
465                 470                 475                 480 


Glu Glu Lys Val Asp Thr Asp Asp Arg Thr Glu Gly Tyr Leu Arg Ala 
                485                 490                 495     


Asp Ser Gln Glu Pro Ser His Phe Asp Ser Gln Gln Pro Ala Val Leu 
            500                 505                 510         


Glu Glu Glu Glu Val Met Ile Ala His Ala His Pro Gln Glu Val Tyr 
        515                 520                 525             


Asn Glu Tyr Val Pro Arg Gly Cys Lys Asn Lys Cys His Ser His Phe 
    530                 535                 540                 


His Asp Thr Leu Gly Gln Ser Asp Asp Leu Ile His His His His Asp 
545                 550                 555                 560 


Tyr His His Ile Leu His His His His His Gln Asn His His Pro His 
                565                 570                 575     


Ser His Ser Gln Arg Tyr Ser Arg Glu Glu Leu Lys Asp Ala Gly Val 
            580                 585                 590         


Ala Thr Leu Ala Trp Met Val Ile Met Gly Asp Gly Leu His Asn Phe 
        595                 600                 605             


Ser Asp Gly Leu Ala Ile Gly Ala Ala Phe Thr Glu Gly Leu Ser Ser 
    610                 615                 620                 


Gly Leu Ser Thr Ser Val Ala Val Phe Cys His Glu Leu Pro His Glu 
625                 630                 635                 640 


Leu Gly Asp Phe Ala Val Leu Leu Lys Ala Gly Met Thr Val Lys Gln 
                645                 650                 655     


Ala Val Leu Tyr Asn Ala Leu Ser Ala Met Leu Ala Tyr Leu Gly Met 
            660                 665                 670         


Ala Thr Gly Ile Phe Ile Gly His Tyr Ala Glu Asn Val Ser Met Trp 
        675                 680                 685             


Ile Phe Ala Leu Thr Ala Gly Leu Phe Met Tyr Val Ala Leu Val Asp 
    690                 695                 700                 


Met Val Pro Glu Met Leu His Asn Asp Ala Ser Asp His Gly Cys Ser 
705                 710                 715                 720 


Arg Trp Gly Tyr Phe Phe Leu Gln Asn Ala Gly Met Leu Leu Gly Phe 
                725                 730                 735     


Gly Ile Met Leu Leu Ile Ser Ile Phe Glu His Lys Ile Val Phe Arg 
            740                 745                 750         


Ile Asn Phe 
        755 


<210>  3746
<211>  931
<212>  PRT
<213>  Homo sapiens

<400>  3746

Met Leu Leu Phe Phe Thr Leu Gly Leu Leu Ile His Phe Val Phe Phe 
1               5                   10                  15      


Ala Ser Ile Phe Asp Ile Tyr Phe Thr Ser Pro Leu Val His Gly Met 
            20                  25                  30          


Thr Pro Gln Phe Thr Pro Leu Pro Pro Pro Ala Arg Arg Leu Val Leu 
        35                  40                  45              


Phe Val Ala Asp Gly Leu Arg Ala Asp Ala Leu Tyr Glu Leu Asp Glu 
    50                  55                  60                  


Asn Gly Asn Ser Arg Ala Pro Phe Ile Arg Asn Ile Ile Met His Glu 
65                  70                  75                  80  


Gly Ser Trp Gly Ile Ser His Thr Arg Val Pro Thr Glu Ser Arg Pro 
                85                  90                  95      


Gly His Val Ala Leu Ile Ala Gly Phe Tyr Glu Asp Val Ser Ala Val 
            100                 105                 110         


Ala Lys Gly Trp Lys Glu Asn Pro Val Glu Phe Asp Ser Leu Phe Asn 
        115                 120                 125             


Glu Ser Lys Tyr Thr Trp Ser Trp Gly Ser Pro Asp Ile Leu Pro Met 
    130                 135                 140                 


Phe Ala Lys Gly Ala Ser Gly Asp His Val Tyr Thr Tyr Ser Tyr Asp 
145                 150                 155                 160 


Ala Lys Arg Glu Asp Phe Gly Ala Gln Asp Ala Thr Lys Leu Asp Thr 
                165                 170                 175     


Trp Val Phe Asp Asn Val Lys Asp Phe Phe His His Ala Arg Asn Asn 
            180                 185                 190         


Gln Ser Leu Phe Ser Lys Ile Asn Glu Glu Lys Ile Val Phe Phe Leu 
        195                 200                 205             


His Leu Leu Gly Ile Asp Thr Asn Gly His Ala His Arg Pro Ser Ser 
    210                 215                 220                 


Arg Asp Tyr Lys His Asn Ile Lys Lys Val Asp Asp Gly Val Lys Glu 
225                 230                 235                 240 


Ile Val Ser Met Phe Asn His Phe Tyr Gly Asn Asp Gly Lys Thr Thr 
                245                 250                 255     


Phe Ile Phe Thr Ser Asp His Gly Met Thr Asp Trp Gly Ser His Gly 
            260                 265                 270         


Ala Gly His Pro Ser Glu Thr Leu Thr Pro Leu Val Thr Trp Gly Ala 
        275                 280                 285             


Gly Ile Lys Tyr Pro Gln Arg Val Ser Ala Gln Gln Phe Asp Asp Ala 
    290                 295                 300                 


Phe Leu Lys Glu Trp Arg Leu Glu Asn Trp Lys Arg Leu Asp Val Asn 
305                 310                 315                 320 


Gln Ala Asp Ile Ala Pro Leu Met Thr Ser Leu Ile Gly Val Pro Phe 
                325                 330                 335     


Pro Leu Asn Ser Val Gly Ile Leu Pro Val Asp Tyr Leu Asn Asn Thr 
            340                 345                 350         


Asp Leu Phe Lys Ala Glu Ser Met Phe Thr Asn Ala Val Gln Ile Leu 
        355                 360                 365             


Glu Gln Phe Lys Val Lys Met Thr Gln Lys Lys Glu Val Thr Leu Pro 
    370                 375                 380                 


Phe Leu Phe Thr Pro Phe Lys Leu Leu Ser Asp Ser Lys Gln Phe Asn 
385                 390                 395                 400 


Ile Leu Arg Lys Ala Arg Ser Tyr Ile Lys His Arg Lys Phe Asp Glu 
                405                 410                 415     


Val Val Ser Leu Cys Lys Glu Leu Ile His Leu Ala Leu Lys Gly Leu 
            420                 425                 430         


Ser Tyr Tyr His Thr Tyr Asp Arg Phe Phe Leu Gly Val Asn Val Val 
        435                 440                 445             


Ile Gly Phe Val Gly Trp Ile Ser Tyr Ala Ser Leu Leu Ile Ile Lys 
    450                 455                 460                 


Ser His Ser Asn Leu Ile Lys Gly Val Ser Lys Glu Val Lys Lys Pro 
465                 470                 475                 480 


Ser His Leu Leu Pro Cys Ser Phe Val Ala Ile Gly Ile Leu Val Ala 
                485                 490                 495     


Phe Phe Leu Leu Ile Gln Ala Cys Pro Trp Thr Tyr Tyr Val Tyr Gly 
            500                 505                 510         


Leu Leu Pro Leu Pro Ile Trp Tyr Ala Val Leu Arg Glu Phe Gln Val 
        515                 520                 525             


Ile Gln Asp Leu Val Val Ser Val Leu Thr Tyr Pro Leu Ser His Phe 
    530                 535                 540                 


Val Gly Tyr Leu Leu Ala Phe Thr Leu Gly Ile Glu Val Leu Val Leu 
545                 550                 555                 560 


Ser Phe Phe Tyr Arg Tyr Met Leu Thr Ala Gly Leu Thr Ala Phe Ala 
                565                 570                 575     


Ala Trp Pro Phe Leu Thr Arg Leu Trp Thr Arg Ala Lys Met Thr Ser 
            580                 585                 590         


Leu Ser Trp Thr Phe Phe Ser Leu Leu Leu Ala Val Phe Pro Leu Met 
        595                 600                 605             


Pro Val Val Gly Arg Lys Pro Asp Ile Ser Leu Val Met Gly Ala Gly 
    610                 615                 620                 


Leu Leu Val Leu Leu Leu Ser Leu Cys Val Val Thr Ser Leu Met Lys 
625                 630                 635                 640 


Arg Lys Asp Ser Phe Ile Lys Glu Glu Leu Leu Val His Leu Leu Gln 
                645                 650                 655     


Val Leu Ser Thr Val Leu Ser Met Tyr Val Val Tyr Ser Thr Gln Ser 
            660                 665                 670         


Ser Leu Leu Arg Lys Gln Gly Leu Pro Leu Met Asn Gln Ile Ile Ser 
        675                 680                 685             


Trp Ala Thr Leu Ala Ser Ser Leu Val Val Pro Leu Leu Ser Ser Pro 
    690                 695                 700                 


Val Leu Phe Gln Arg Leu Phe Ser Ile Leu Leu Ser Leu Met Ser Thr 
705                 710                 715                 720 


Tyr Leu Leu Leu Ser Thr Gly Tyr Glu Ala Leu Phe Pro Leu Val Leu 
                725                 730                 735     


Ser Cys Leu Met Phe Val Trp Ile Asn Ile Glu Gln Glu Thr Leu Gln 
            740                 745                 750         


Gln Ser Gly Val Cys Cys Lys Gln Lys Leu Thr Ser Ile Gln Phe Ser 
        755                 760                 765             


Tyr Asn Thr Asp Ile Thr Gln Phe Arg Gln Leu Tyr Leu Asp Asp Ile 
    770                 775                 780                 


Arg Arg Ala Phe Phe Leu Val Phe Phe Leu Val Thr Ala Phe Phe Gly 
785                 790                 795                 800 


Thr Gly Asn Ile Ala Ser Ile Asn Ser Phe Asp Leu Ala Ser Val Tyr 
                805                 810                 815     


Cys Phe Leu Thr Val Phe Ser Pro Phe Met Met Gly Ala Leu Met Met 
            820                 825                 830         


Trp Lys Ile Leu Ile Pro Phe Val Leu Val Met Cys Ala Phe Glu Ala 
        835                 840                 845             


Val Gln Leu Thr Thr Gln Leu Ser Ser Lys Ser Leu Phe Leu Ile Val 
    850                 855                 860                 


Leu Val Ile Ser Asp Ile Met Ala Leu His Phe Phe Phe Leu Val Lys 
865                 870                 875                 880 


Asp Tyr Gly Ser Trp Leu Asp Ile Gly Thr Ser Ile Ser His Tyr Val 
                885                 890                 895     


Ile Val Met Ser Met Thr Ile Phe Leu Val Phe Leu Asn Gly Leu Ala 
            900                 905                 910         


Gln Leu Leu Thr Thr Lys Lys Leu Arg Leu Cys Gly Lys Pro Lys Ser 
        915                 920                 925             


His Phe Met 
    930     


<210>  3747
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  3747

Met Ala Thr Pro Gln Ser Ile Phe Ile Phe Ala Ile Cys Ile Leu Met 
1               5                   10                  15      


Ile Thr Glu Leu Ile Leu Ala Ser Lys Ser Tyr Tyr Asp Ile Leu Gly 
            20                  25                  30          


Val Pro Lys Ser Ala Ser Glu Arg Gln Ile Lys Lys Ala Phe His Lys 
        35                  40                  45              


Leu Ala Met Lys Tyr His Pro Asp Lys Asn Lys Ser Pro Asp Ala Glu 
    50                  55                  60                  


Ala Lys Phe Arg Glu Ile Ala Glu Ala Tyr Glu Thr Leu Ser Asp Ala 
65                  70                  75                  80  


Asn Arg Arg Lys Glu Tyr Asp Thr Leu Gly His Ser Ala Phe Thr Ser 
                85                  90                  95      


Gly Lys Gly Gln Arg Gly Ser Gly Ser Ser Phe Glu Gln Ser Phe Asn 
            100                 105                 110         


Phe Asn Phe Asp Asp Leu Phe Lys Asp Phe Gly Phe Phe Gly Gln Asn 
        115                 120                 125             


Gln Asn Thr Gly Ser Lys Lys Arg Phe Glu Asn His Phe Gln Thr Arg 
    130                 135                 140                 


Gln Asp Gly Gly Ser Ser Arg Gln Arg His His Phe Gln Glu Phe Ser 
145                 150                 155                 160 


Phe Gly Gly Gly Leu Phe Asp Asp Met Phe Glu Asp Met Glu Lys Met 
                165                 170                 175     


Phe Ser Phe Ser Gly Phe Asp Ser Thr Asn Gln His Thr Val Gln Thr 
            180                 185                 190         


Glu Asn Arg Phe His Gly Ser Ser Lys His Cys Arg Thr Val Thr Gln 
        195                 200                 205             


Arg Arg Gly Asn Met Val Thr Thr Tyr Thr Asp Cys Ser Gly Gln 
    210                 215                 220             


<210>  3748
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  3748

Met Arg Phe Lys Asn Arg Phe Gln Arg Phe Met Asn His Arg Ala Pro 
1               5                   10                  15      


Ala Asn Gly Arg Tyr Lys Pro Thr Cys Tyr Glu His Ala Ala Asn Cys 
            20                  25                  30          


Tyr Thr His Ala Phe Leu Ile Val Pro Ala Ile Val Gly Ser Ala Leu 
        35                  40                  45              


Leu His Arg Leu Ser Asp Asp Cys Trp Glu Lys Ile Thr Ala Trp Ile 
    50                  55                  60                  


Tyr Gly Met Gly Leu Cys Ala Leu Phe Ile Val Ser Thr Val Phe His 
65                  70                  75                  80  


Ile Val Ser Trp Lys Lys Ser His Leu Arg Thr Val Glu His Cys Phe 
                85                  90                  95      


His Met Cys Asp Arg Met Val Ile Tyr Phe Phe Ile Ala Ala Ser Tyr 
            100                 105                 110         


Ala Pro Trp Leu Asn Leu Arg Glu Leu Gly Pro Leu Ala Ser His Met 
        115                 120                 125             


Arg Trp Phe Ile Trp Leu Met Ala Ala Gly Gly Thr Ile Tyr Val Phe 
    130                 135                 140                 


Leu Tyr His Glu Lys Tyr Lys Val Val Glu Leu Phe Phe Tyr Leu Thr 
145                 150                 155                 160 


Met Gly Phe Ser Pro Ala Leu Val Val Thr Ser Met Asn Asn Thr Asp 
                165                 170                 175     


Gly Leu Gln Glu Leu Ala Cys Gly Gly Leu Ile Tyr Cys Leu Gly Val 
            180                 185                 190         


Val Phe Phe Lys Ser Asp Gly Ile Ile Pro Phe Ala His Ala Ile Trp 
        195                 200                 205             


His Leu Phe Val Ala Thr Ala Ala Ala Val His Tyr Tyr Ala Ile Trp 
    210                 215                 220                 


Lys Tyr Leu Tyr Arg Ser Pro Thr Asp Phe Met Arg His Leu 
225                 230                 235             


<210>  3749
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  3749

Met Ala Arg Glu Asp Ser Val Lys Cys Leu Arg Cys Leu Leu Tyr Ala 
1               5                   10                  15      


Leu Asn Leu Leu Phe Trp Leu Met Ser Ile Ser Val Leu Ala Val Ser 
            20                  25                  30          


Ala Trp Met Arg Asp Tyr Leu Asn Asn Val Leu Thr Leu Thr Ala Glu 
        35                  40                  45              


Thr Arg Val Glu Glu Ala Val Ile Leu Thr Tyr Phe Pro Val Val His 
    50                  55                  60                  


Pro Val Met Ile Ala Val Cys Cys Phe Leu Ile Ile Val Gly Met Leu 
65                  70                  75                  80  


Gly Tyr Cys Gly Thr Val Lys Arg Asn Leu Leu Leu Leu Ala Trp Tyr 
                85                  90                  95      


Phe Gly Ser Leu Leu Val Ile Phe Cys Val Glu Leu Ala Cys Gly Val 
            100                 105                 110         


Trp Thr Tyr Glu Gln Glu Leu Met Val Pro Val Gln Trp Ser Asp Met 
        115                 120                 125             


Val Thr Leu Lys Ala Arg Met Thr Asn Tyr Gly Leu Pro Arg Tyr Arg 
    130                 135                 140                 


Trp Leu Thr His Ala Trp Asn Phe Phe Gln Arg Glu Phe Lys Cys Cys 
145                 150                 155                 160 


Gly Val Val Tyr Phe Thr Asp Trp Leu Glu Met Thr Glu Met Asp Trp 
                165                 170                 175     


Pro Pro Asp Ser Cys Cys Val Arg Glu Phe Pro Gly Cys Ser Lys Gln 
            180                 185                 190         


Ala His Gln Glu Asp Leu Ser Asp Leu Tyr Gln Glu Gly Cys Gly Lys 
        195                 200                 205             


Lys Met Tyr Ser Phe Leu Arg Gly Thr Lys Gln Leu Gln Val Leu Arg 
    210                 215                 220                 


Phe Leu Gly Ile Ser Ile Gly Val Thr Gln Ile Leu Ala Met Ile Leu 
225                 230                 235                 240 


Thr Ile Thr Leu Leu Trp Ala Leu Tyr Tyr Asp Arg Arg Glu Pro Gly 
                245                 250                 255     


Thr Asp Gln Met Met Ser Leu Lys Asn Asp Asn Ser Gln His Leu Ser 
            260                 265                 270         


Cys Pro Ser Val Glu Leu Leu Lys Pro Ser Leu Ser Arg Ile Phe Glu 
        275                 280                 285             


His Thr Ser Met Ala Asn Ser Phe Asn Thr His Phe Glu Met Glu Glu 
    290                 295                 300                 


Leu 
305 


<210>  3750
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  3750

Met Pro Arg Gly Asp Ser Glu Gln Val Arg Tyr Cys Ala Arg Phe Ser 
1               5                   10                  15      


Tyr Leu Trp Leu Lys Phe Ser Leu Ile Ile Tyr Ser Thr Val Phe Trp 
            20                  25                  30          


Leu Ile Gly Ala Leu Val Leu Ser Val Gly Ile Tyr Ala Glu Val Glu 
        35                  40                  45              


Arg Gln Lys Tyr Lys Thr Leu Glu Ser Ala Phe Leu Ala Pro Ala Ile 
    50                  55                  60                  


Ile Leu Ile Leu Leu Gly Val Val Met Phe Met Val Ser Phe Ile Gly 
65                  70                  75                  80  


Val Leu Ala Ser Leu Arg Asp Asn Leu Tyr Leu Leu Gln Ala Phe Met 
                85                  90                  95      


Tyr Ile Leu Gly Ile Cys Leu Ile Met Glu Leu Ile Gly Gly Val Val 
            100                 105                 110         


Ala Leu Thr Phe Arg Asn Gln Thr Ile Asp Phe Leu Asn Asp Asn Ile 
        115                 120                 125             


Arg Arg Gly Ile Glu Asn Tyr Tyr Asp Asp Leu Asp Phe Lys Asn Ile 
    130                 135                 140                 


Met Asp Phe Val Gln Lys Lys Phe Lys Cys Cys Gly Gly Glu Asp Tyr 
145                 150                 155                 160 


Arg Asp Trp Ser Lys Asn Gln Tyr His Asp Cys Ser Ala Pro Gly Pro 
                165                 170                 175     


Leu Ala Cys Gly Val Pro Tyr Thr Cys Cys Ile Arg Asn Thr Thr Glu 
            180                 185                 190         


Val Val Asn Thr Met Cys Gly Tyr Lys Thr Ile Asp Lys Glu Arg Phe 
        195                 200                 205             


Ser Val Gln Asp Val Ile Tyr Val Arg Gly Cys Thr Asn Ala Val Ile 
    210                 215                 220                 


Ile Trp Phe Met Asp Asn Tyr Thr Ile Met Ala Gly Ile Leu Leu Gly 
225                 230                 235                 240 


Ile Leu Leu Pro Gln Phe Leu Gly Val Leu Leu Thr Leu Leu Tyr Ile 
                245                 250                 255     


Thr Arg Val Glu Asp Ile Ile Met Glu His Ser Val Thr Asp Gly Leu 
            260                 265                 270         


Leu Gly Pro Gly Ala Lys Pro Ser Val Glu Ala Ala Gly Thr Gly Cys 
        275                 280                 285             


Cys Leu Cys Tyr Pro Asn 
    290                 


<210>  3751
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  3751

Met Asp Arg His Ser Ser Tyr Ile Phe Ile Trp Leu Gln Leu Glu Leu 
1               5                   10                  15      


Cys Ala Met Ala Val Leu Leu Thr Lys Gly Glu Ile Arg Cys Tyr Cys 
            20                  25                  30          


Asp Ala Ala His Cys Val Ala Thr Gly Tyr Met Cys Lys Ser Glu Leu 
        35                  40                  45              


Ser Ala Cys Phe Ser Arg Leu Leu Asp Pro Gln Asn Ser Asn Ser Pro 
    50                  55                  60                  


Leu Thr His Gly Cys Leu Asp Ser Leu Ala Ser Thr Thr Asp Ile Cys 
65                  70                  75                  80  


Gln Ala Lys Gln Ala Arg Asn His Ser Gly Thr Thr Ile Pro Thr Leu 
                85                  90                  95      


Glu Cys Cys His Glu Asp Met Cys Asn Tyr Arg Gly Leu His Asp Val 
            100                 105                 110         


Leu Ser Pro Pro Arg Gly Glu Ala Ser Gly Gln Gly Asn Arg Tyr Gln 
        115                 120                 125             


His Asp Gly Ser Arg Asn Leu Ile Thr Lys Val Gln Glu Leu Thr Ser 
    130                 135                 140                 


Ser Lys Glu Leu Trp Phe Arg Ala Ala Val Ile Ala Val Pro Ile Ala 
145                 150                 155                 160 


Gly Gly Leu Ile Leu Val Leu Leu Ile Met Leu Ala Leu Arg Met Leu 
                165                 170                 175     


Arg Ser Glu Asn Lys Arg Leu Gln Asp Gln Arg Gln Gln Met Leu Ser 
            180                 185                 190         


Arg Leu His Tyr Ser Phe His Gly His His Ser Lys Lys Gly Gln Val 
        195                 200                 205             


Ala Lys Leu Asp Leu Glu Cys Met Val Pro Val Ser Gly His Glu Asn 
    210                 215                 220                 


Cys Cys Leu Thr Cys Asp Lys Met Arg Gln Ala Asp Leu Ser Asn Asp 
225                 230                 235                 240 


Lys Ile Leu Ser Leu Val His Trp Gly Met Tyr Ser Gly His Gly Lys 
                245                 250                 255     


Leu Glu Phe Val 
            260 


<210>  3752
<211>  1086
<212>  PRT
<213>  Homo sapiens

<400>  3752

Met Ala Asn Leu Leu Lys Thr Val Val Thr Gly Cys Ser Cys Pro Leu 
1               5                   10                  15      


Leu Ser Asn Leu Gly Ser Cys Lys Gly Leu Arg Val Lys Lys Asp Phe 
            20                  25                  30          


Leu Arg Thr Phe Tyr Thr His Gln Glu Leu Trp Cys Lys Ala Pro Val 
        35                  40                  45              


Lys Pro Gly Ile Pro Tyr Lys Gln Leu Thr Val Gly Val Pro Lys Glu 
    50                  55                  60                  


Ile Phe Gln Asn Glu Lys Arg Val Ala Leu Ser Pro Ala Gly Val Gln 
65                  70                  75                  80  


Asn Leu Val Lys Gln Gly Phe Asn Val Val Val Glu Ser Gly Ala Gly 
                85                  90                  95      


Glu Ala Ser Lys Phe Ser Asp Asp His Tyr Arg Val Ala Gly Ala Gln 
            100                 105                 110         


Ile Gln Gly Ala Lys Glu Val Leu Ala Ser Asp Leu Val Val Lys Val 
        115                 120                 125             


Arg Ala Pro Met Val Asn Pro Thr Leu Gly Val His Glu Ala Asp Leu 
    130                 135                 140                 


Leu Lys Thr Ser Gly Thr Leu Ile Ser Phe Ile Tyr Pro Ala Gln Asn 
145                 150                 155                 160 


Pro Glu Leu Leu Asn Lys Leu Ser Gln Arg Lys Thr Thr Val Leu Ala 
                165                 170                 175     


Met Asp Gln Val Pro Arg Val Thr Ile Ala Gln Gly Tyr Asp Ala Leu 
            180                 185                 190         


Ser Ser Met Ala Asn Ile Ala Gly Tyr Lys Ala Val Val Leu Ala Ala 
        195                 200                 205             


Asn His Phe Gly Arg Phe Phe Thr Gly Gln Ile Thr Ala Ala Gly Lys 
    210                 215                 220                 


Val Pro Pro Ala Lys Ile Leu Ile Val Gly Gly Gly Val Ala Gly Leu 
225                 230                 235                 240 


Ala Ser Ala Gly Ala Ala Lys Ser Met Gly Ala Ile Val Arg Gly Phe 
                245                 250                 255     


Asp Thr Arg Ala Ala Ala Leu Glu Gln Phe Lys Ser Leu Gly Ala Glu 
            260                 265                 270         


Pro Leu Glu Val Asp Leu Lys Glu Ser Gly Glu Gly Gln Gly Gly Tyr 
        275                 280                 285             


Ala Lys Glu Met Ser Lys Glu Phe Ile Glu Ala Glu Met Lys Leu Phe 
    290                 295                 300                 


Ala Gln Gln Cys Lys Glu Val Asp Ile Leu Ile Ser Thr Ala Leu Ile 
305                 310                 315                 320 


Pro Gly Lys Lys Ala Pro Val Leu Phe Asn Lys Glu Met Ile Glu Ser 
                325                 330                 335     


Met Lys Glu Gly Ser Val Val Val Asp Leu Ala Ala Glu Ala Gly Gly 
            340                 345                 350         


Asn Phe Glu Thr Thr Lys Pro Gly Glu Leu Tyr Ile His Lys Gly Ile 
        355                 360                 365             


Thr His Ile Gly Tyr Thr Asp Leu Pro Ser Arg Met Ala Thr Gln Ala 
    370                 375                 380                 


Ser Thr Leu Tyr Ser Asn Asn Ile Thr Lys Leu Leu Lys Ala Ile Ser 
385                 390                 395                 400 


Pro Asp Lys Asp Asn Phe Tyr Phe Asp Val Lys Asp Asp Phe Asp Phe 
                405                 410                 415     


Gly Thr Met Gly His Val Ile Arg Gly Thr Val Val Met Lys Asp Gly 
            420                 425                 430         


Lys Val Ile Phe Pro Ala Pro Thr Pro Lys Asn Ile Pro Gln Gly Ala 
        435                 440                 445             


Pro Val Lys Gln Lys Thr Val Ala Glu Leu Glu Ala Glu Lys Ala Ala 
    450                 455                 460                 


Thr Ile Thr Pro Phe Arg Lys Thr Met Ser Thr Ala Ser Ala Tyr Thr 
465                 470                 475                 480 


Ala Gly Leu Thr Gly Ile Leu Gly Leu Gly Ile Ala Ala Pro Asn Leu 
                485                 490                 495     


Ala Phe Ser Gln Met Val Thr Thr Phe Gly Leu Ala Gly Ile Val Gly 
            500                 505                 510         


Tyr His Thr Val Trp Gly Val Thr Pro Ala Leu His Ser Pro Leu Met 
        515                 520                 525             


Ser Val Thr Asn Ala Ile Ser Gly Leu Thr Ala Val Gly Gly Leu Ala 
    530                 535                 540                 


Leu Met Gly Gly His Leu Tyr Pro Ser Thr Thr Ser Gln Gly Leu Ala 
545                 550                 555                 560 


Ala Leu Ala Ala Phe Ile Ser Ser Val Asn Ile Ala Gly Gly Phe Leu 
                565                 570                 575     


Val Thr Gln Arg Met Leu Asp Met Phe Lys Arg Pro Thr Asp Pro Pro 
            580                 585                 590         


Glu Tyr Asn Tyr Leu Tyr Leu Leu Pro Ala Gly Thr Phe Val Gly Gly 
        595                 600                 605             


Tyr Leu Ala Ala Leu Tyr Ser Gly Tyr Asn Ile Glu Gln Ile Met Tyr 
    610                 615                 620                 


Leu Gly Ser Gly Leu Cys Cys Val Gly Ala Leu Ala Gly Leu Ser Thr 
625                 630                 635                 640 


Gln Gly Thr Ala Arg Leu Gly Asn Ala Leu Gly Met Ile Gly Val Ala 
                645                 650                 655     


Gly Gly Leu Ala Ala Thr Leu Gly Val Leu Lys Pro Gly Pro Glu Leu 
            660                 665                 670         


Leu Ala Gln Met Ser Gly Ala Met Ala Leu Gly Gly Thr Ile Gly Leu 
        675                 680                 685             


Thr Ile Ala Lys Arg Ile Gln Ile Ser Asp Leu Pro Gln Leu Val Ala 
    690                 695                 700                 


Ala Phe His Ser Leu Val Gly Leu Ala Ala Val Leu Thr Cys Ile Ala 
705                 710                 715                 720 


Glu Tyr Ile Ile Glu Tyr Pro His Phe Ala Thr Asp Ala Ala Ala Asn 
                725                 730                 735     


Leu Thr Lys Ile Val Ala Tyr Leu Gly Thr Tyr Ile Gly Gly Val Thr 
            740                 745                 750         


Phe Ser Gly Ser Leu Ile Ala Tyr Gly Lys Leu Gln Gly Leu Leu Lys 
        755                 760                 765             


Ser Ala Pro Leu Leu Leu Pro Gly Arg His Leu Leu Asn Ala Gly Leu 
    770                 775                 780                 


Leu Ala Ala Ser Val Gly Gly Ile Ile Pro Phe Met Val Asp Pro Ser 
785                 790                 795                 800 


Phe Thr Thr Gly Ile Thr Cys Leu Gly Ser Val Ser Ala Leu Ser Ala 
                805                 810                 815     


Val Met Gly Val Thr Leu Thr Ala Ala Ile Gly Gly Ala Asp Met Pro 
            820                 825                 830         


Val Val Ile Thr Val Leu Asn Ser Tyr Ser Gly Trp Ala Leu Cys Ala 
        835                 840                 845             


Glu Gly Phe Leu Leu Asn Asn Asn Leu Leu Thr Ile Val Gly Ala Leu 
    850                 855                 860                 


Ile Gly Ser Ser Gly Ala Ile Leu Ser Tyr Ile Met Cys Val Ala Met 
865                 870                 875                 880 


Asn Arg Ser Leu Ala Asn Val Ile Leu Gly Gly Tyr Gly Thr Thr Ser 
                885                 890                 895     


Thr Ala Gly Gly Lys Pro Met Glu Ile Ser Gly Thr His Thr Glu Ile 
            900                 905                 910         


Asn Leu Asp Asn Ala Ile Asp Met Ile Arg Glu Ala Asn Ser Ile Ile 
        915                 920                 925             


Ile Thr Pro Gly Tyr Gly Leu Cys Ala Ala Lys Ala Gln Tyr Pro Ile 
    930                 935                 940                 


Ala Asp Leu Val Lys Met Leu Thr Glu Gln Gly Lys Lys Val Arg Phe 
945                 950                 955                 960 


Gly Ile His Pro Val Ala Gly Arg Met Pro Gly Gln Leu Asn Val Leu 
                965                 970                 975     


Leu Ala Glu Ala Gly Val Pro Tyr Asp Ile Val Leu Glu Met Asp Glu 
            980                 985                 990         


Ile Asn His Asp Phe Pro Asp Thr  Asp Leu Val Leu Val  Ile Gly Ala 
        995                 1000                 1005             


Asn Asp  Thr Val Asn Ser Ala  Ala Gln Glu Asp Pro  Asn Ser Ile 
    1010                 1015                 1020             


Ile Ala  Gly Met Pro Val Leu  Glu Val Trp Lys Ser  Lys Gln Val 
    1025                 1030                 1035             


Ile Val  Met Lys Arg Ser Leu  Gly Val Gly Tyr Ala  Ala Val Asp 
    1040                 1045                 1050             


Asn Pro  Ile Phe Tyr Lys Pro  Asn Thr Ala Met Leu  Leu Gly Asp 
    1055                 1060                 1065             


Ala Lys  Lys Thr Cys Asp Ala  Leu Gln Ala Lys Val  Arg Glu Ser 
    1070                 1075                 1080             


Tyr Gln  Lys 
    1085     


<210>  3753
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  3753

Met Glu Thr Ser Ser Pro Arg Pro Pro Arg Pro Ser Ser Asn Pro Gly 
1               5                   10                  15      


Leu Ser Leu Asp Ala Arg Leu Gly Val Asp Thr Arg Leu Trp Ala Lys 
            20                  25                  30          


Val Leu Phe Thr Ala Leu Tyr Ala Leu Ile Trp Ala Leu Gly Ala Ala 
        35                  40                  45              


Gly Asn Ala Leu Ser Val His Val Val Leu Lys Ala Arg Ala Gly Arg 
    50                  55                  60                  


Ala Gly Arg Leu Arg His His Val Leu Ser Leu Ala Leu Ala Gly Leu 
65                  70                  75                  80  


Leu Leu Leu Leu Val Gly Val Pro Val Glu Leu Tyr Ser Phe Val Trp 
                85                  90                  95      


Phe His Tyr Pro Trp Val Phe Gly Asp Leu Gly Cys Arg Gly Tyr Tyr 
            100                 105                 110         


Phe Val His Glu Leu Cys Ala Tyr Ala Thr Val Leu Ser Val Ala Gly 
        115                 120                 125             


Leu Ser Ala Glu Arg Cys Leu Ala Val Cys Gln Pro Leu Arg Ala Arg 
    130                 135                 140                 


Ser Leu Leu Thr Pro Arg Arg Thr Arg Trp Leu Val Ala Leu Ser Trp 
145                 150                 155                 160 


Ala Ala Ser Leu Gly Leu Ala Leu Pro Met Ala Val Ile Met Gly Gln 
                165                 170                 175     


Lys His Glu Leu Glu Thr Ala Asp Gly Glu Pro Glu Pro Ala Ser Arg 
            180                 185                 190         


Val Cys Thr Val Leu Val Ser Arg Thr Ala Leu Gln Val Phe Ile Gln 
        195                 200                 205             


Val Asn Val Leu Val Ser Phe Val Leu Pro Leu Ala Leu Thr Ala Phe 
    210                 215                 220                 


Leu Asn Gly Val Thr Val Ser His Leu Leu Ala Leu Cys Ser Gln Val 
225                 230                 235                 240 


Pro Ser Thr Ser Thr Pro Gly Ser Ser Thr Pro Ser Arg Leu Glu Leu 
                245                 250                 255     


Leu Ser Glu Glu Gly Leu Leu Ser Phe Ile Val Trp Lys Lys Thr Phe 
            260                 265                 270         


Ile Gln Gly Gly Gln Val Ser Leu Val Arg His Lys Asp Val Arg Arg 
        275                 280                 285             


Ile Arg Ser Leu Gln Arg Ser Val Gln Val Leu Arg Ala Ile Val Val 
    290                 295                 300                 


Met Tyr Val Ile Cys Trp Leu Pro Tyr His Ala Arg Arg Leu Met Tyr 
305                 310                 315                 320 


Cys Tyr Val Pro Asp Asp Ala Trp Thr Asp Pro Leu Tyr Asn Phe Tyr 
                325                 330                 335     


His Tyr Phe Tyr Met Val Thr Asn Thr Leu Phe Tyr Val Ser Ser Ala 
            340                 345                 350         


Val Thr Pro Leu Leu Tyr Asn Ala Val Ser Ser Ser Phe Arg Lys Leu 
        355                 360                 365             


Phe Leu Glu Ala Val Ser Ser Leu Cys Gly Glu His His Pro Met Lys 
    370                 375                 380                 


Arg Leu Pro Pro Lys Pro Gln Ser Pro Thr Leu Met Asp Thr Ala Ser 
385                 390                 395                 400 


Gly Phe Gly Asp Pro Pro Glu Thr Arg Thr 
                405                 410 


<210>  3754
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  3754

Met Leu Leu Cys Phe Arg Phe Gly Asn Gln Ser Met Lys Arg Glu Asn 
1               5                   10                  15      


Phe Thr Leu Ile Thr Asp Phe Val Phe Gln Gly Phe Ser Ser Phe His 
            20                  25                  30          


Glu Gln Gln Ile Thr Leu Phe Gly Val Phe Leu Ala Leu Tyr Ile Leu 
        35                  40                  45              


Thr Leu Ala Gly Asn Ile Ile Ile Val Thr Ile Ile Arg Met Asp Leu 
    50                  55                  60                  


His Leu His Thr Pro Met Tyr Phe Phe Leu Ser Met Leu Ser Thr Ser 
65                  70                  75                  80  


Glu Thr Val Tyr Thr Leu Val Ile Leu Pro Arg Met Leu Ser Ser Leu 
                85                  90                  95      


Val Gly Met Ser Gln Pro Ile Ser Leu Ala Gly Cys Ala Thr Gln Met 
            100                 105                 110         


Phe Phe Phe Val Thr Phe Gly Ile Thr Asn Cys Phe Leu Leu Thr Ala 
        115                 120                 125             


Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu Arg Tyr Met 
    130                 135                 140                 


Val Ile Met Asn Lys Arg Leu Arg Ile Gln Leu Val Leu Gly Ala Cys 
145                 150                 155                 160 


Ser Ile Gly Leu Ile Val Ala Ile Thr Gln Val Thr Ser Val Phe Arg 
                165                 170                 175     


Leu Pro Phe Cys Ala Arg Lys Val Pro His Phe Phe Cys Asp Ile Arg 
            180                 185                 190         


Pro Val Met Lys Leu Ser Cys Ile Asp Thr Thr Val Asn Glu Ile Leu 
        195                 200                 205             


Thr Leu Ile Ile Ser Val Leu Val Leu Val Val Pro Met Gly Leu Val 
    210                 215                 220                 


Phe Ile Ser Tyr Val Leu Ile Ile Ser Thr Ile Leu Lys Ile Ala Ser 
225                 230                 235                 240 


Val Glu Gly Arg Lys Lys Ala Phe Ala Thr Cys Ala Ser His Leu Thr 
                245                 250                 255     


Val Val Ile Val His Tyr Ser Cys Ala Ser Ile Ala Tyr Leu Lys Pro 
            260                 265                 270         


Lys Ser Glu Asn Thr Arg Glu His Asp Gln Leu Ile Ser Val Thr Tyr 
        275                 280                 285             


Thr Val Ile Thr Pro Leu Leu Asn Pro Val Val Tyr Thr Leu Arg Asn 
    290                 295                 300                 


Lys Glu Val Lys Asp Ala Leu Cys Arg Ala Val Gly Gly Lys Phe Ser 
305                 310                 315                 320 


<210>  3755
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  3755

Met Lys Lys Glu Asn Gln Ser Phe Asn Leu Asp Phe Ile Leu Leu Gly 
1               5                   10                  15      


Val Thr Ser Gln Gln Glu Gln Asn Asn Val Phe Phe Val Ile Phe Leu 
            20                  25                  30          


Cys Ile Tyr Pro Ile Thr Leu Thr Gly Asn Leu Leu Ile Ile Leu Ala 
        35                  40                  45              


Ile Cys Ala Asp Ile Arg Leu His Asn Pro Met Tyr Phe Leu Leu Ala 
    50                  55                  60                  


Asn Leu Ser Leu Val Asp Ile Ile Phe Ser Ser Val Thr Ile Pro Lys 
65                  70                  75                  80  


Val Leu Ala Asn His Leu Leu Gly Ser Lys Phe Ile Ser Phe Gly Gly 
                85                  90                  95      


Cys Leu Met Gln Met Tyr Phe Met Ile Ala Leu Ala Lys Ala Asp Ser 
            100                 105                 110         


Tyr Thr Leu Ala Ala Met Ala Tyr Asp Arg Ala Val Ala Ile Ser Cys 
        115                 120                 125             


Pro Leu His Tyr Thr Thr Ile Met Ser Pro Arg Ser Cys Ile Leu Leu 
    130                 135                 140                 


Ile Ala Gly Ser Trp Val Ile Gly Asn Thr Ser Ala Leu Pro His Thr 
145                 150                 155                 160 


Leu Leu Thr Ala Ser Leu Ser Phe Cys Gly Asn Gln Glu Val Ala Asn 
                165                 170                 175     


Phe Tyr Cys Asp Ile Met Pro Leu Leu Lys Leu Ser Cys Ser Asp Val 
            180                 185                 190         


His Phe Asn Val Lys Met Met Tyr Leu Gly Val Gly Val Phe Ser Leu 
        195                 200                 205             


Pro Leu Leu Cys Ile Ile Val Ser Tyr Val Gln Val Phe Ser Thr Val 
    210                 215                 220                 


Phe Gln Val Pro Ser Thr Lys Ser Leu Phe Lys Ala Phe Cys Thr Cys 
225                 230                 235                 240 


Gly Ser His Leu Thr Val Val Phe Leu Tyr Tyr Gly Thr Thr Met Gly 
                245                 250                 255     


Met Tyr Phe Arg Pro Leu Thr Ser Tyr Ser Pro Lys Asp Ala Val Ile 
            260                 265                 270         


Thr Val Met Tyr Val Ala Val Thr Pro Ala Leu Asn Pro Phe Ile Tyr 
        275                 280                 285             


Ser Leu Arg Asn Trp Asp Met Lys Ala Ala Leu Gln Lys Leu Phe Ser 
    290                 295                 300                 


Lys Arg Ile Ser Ser 
305                 


<210>  3756
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  3756

Met Glu Lys Arg Asn Leu Thr Val Val Arg Glu Phe Val Leu Leu Gly 
1               5                   10                  15      


Leu Pro Ser Ser Ala Glu Gln Gln His Leu Leu Ser Val Leu Phe Leu 
            20                  25                  30          


Cys Met Tyr Leu Ala Thr Thr Leu Gly Asn Met Leu Ile Ile Ala Thr 
        35                  40                  45              


Ile Gly Phe Asp Ser His Leu His Ser Pro Met Tyr Phe Phe Leu Ser 
    50                  55                  60                  


Asn Leu Ala Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Gln 
65                  70                  75                  80  


Met Val Val Asn Ile Leu Thr Gly Thr Lys Thr Ile Ser Phe Ala Gly 
                85                  90                  95      


Cys Leu Thr Gln Leu Phe Phe Phe Val Ser Phe Val Asn Met Asp Ser 
            100                 105                 110         


Leu Leu Leu Cys Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 
        115                 120                 125             


Pro Leu His Tyr Thr Ala Arg Met Asn Leu Cys Leu Cys Val Gln Leu 
    130                 135                 140                 


Val Ala Gly Leu Trp Leu Val Thr Tyr Leu His Ala Leu Leu His Thr 
145                 150                 155                 160 


Val Leu Ile Ala Gln Leu Ser Phe Cys Ala Ser Asn Ile Ile His His 
                165                 170                 175     


Phe Phe Cys Asp Leu Asn Pro Leu Leu Gln Leu Ser Cys Ser Asp Val 
            180                 185                 190         


Ser Phe Asn Val Met Ile Ile Phe Ala Val Gly Gly Leu Leu Ala Leu 
        195                 200                 205             


Thr Pro Leu Val Cys Ile Leu Val Ser Tyr Gly Leu Ile Phe Ser Thr 
    210                 215                 220                 


Val Leu Lys Ile Thr Ser Thr Gln Gly Lys Gln Arg Ala Val Ser Thr 
225                 230                 235                 240 


Cys Ser Cys His Leu Ser Val Val Val Leu Phe Tyr Gly Thr Ala Ile 
                245                 250                 255     


Ala Val Tyr Phe Ser Pro Ser Ser Pro His Met Pro Glu Ser Asp Thr 
            260                 265                 270         


Leu Ser Thr Ile Met Tyr Ser Met Val Ala Pro Met Leu Asn Pro Phe 
        275                 280                 285             


Ile Tyr Thr Leu Arg Asn Arg Asp Met Lys Arg Gly Leu Gln Lys Met 
    290                 295                 300                 


Leu Leu Lys Cys Thr Val Phe Gln Gln Gln 
305                 310                 


<210>  3757
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  3757

Met Ser Gly Thr Asn Gln Ser Ser Val Ser Glu Phe Leu Leu Leu Gly 
1               5                   10                  15      


Leu Ser Arg Gln Pro Gln Gln Gln His Leu Leu Phe Val Phe Phe Leu 
            20                  25                  30          


Ser Met Tyr Leu Ala Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Ser 
        35                  40                  45              


Val Ser Ile Asp Ser Cys Leu His Thr Pro Met Tyr Phe Phe Leu Ser 
    50                  55                  60                  


Asn Leu Ser Phe Val Asp Ile Cys Phe Ser Phe Thr Thr Val Pro Lys 
65                  70                  75                  80  


Met Leu Ala Asn His Ile Leu Glu Thr Gln Thr Ile Ser Phe Cys Gly 
                85                  90                  95      


Cys Leu Thr Gln Met Tyr Phe Val Phe Met Phe Val Asp Met Asp Asn 
            100                 105                 110         


Phe Leu Leu Ala Val Met Ala Tyr Asp His Phe Val Ala Val Cys His 
        115                 120                 125             


Pro Leu His Tyr Thr Ala Lys Met Thr His Gln Leu Cys Ala Leu Leu 
    130                 135                 140                 


Val Ala Gly Leu Trp Val Val Ala Asn Leu Asn Val Leu Leu His Thr 
145                 150                 155                 160 


Leu Leu Met Ala Pro Leu Ser Phe Cys Ala Asp Asn Ala Ile Thr His 
                165                 170                 175     


Phe Phe Cys Asp Val Thr Pro Leu Leu Lys Leu Ser Cys Ser Asp Thr 
            180                 185                 190         


His Leu Asn Glu Val Ile Ile Leu Ser Glu Gly Ala Leu Val Met Ile 
        195                 200                 205             


Thr Pro Phe Leu Cys Ile Leu Ala Ser Tyr Met His Ile Thr Cys Thr 
    210                 215                 220                 


Val Leu Lys Val Pro Ser Thr Lys Gly Arg Trp Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Gly Ser His Leu Ala Val Val Leu Leu Phe Tyr Ser Thr Ile Ile 
                245                 250                 255     


Ala Val Tyr Phe Asn Pro Leu Ser Ser His Ser Ala Glu Lys Asp Thr 
            260                 265                 270         


Met Ala Thr Val Leu Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Arg Tyr Leu Lys Gly Ala Leu Lys Lys Val 
    290                 295                 300                 


Val Gly Arg Val Val Phe Ser Val 
305                 310         


<210>  3758
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  3758

Met Asp Asn Ser Asn Trp Thr Ser Val Ser His Phe Val Leu Leu Gly 
1               5                   10                  15      


Ile Ser Thr His Pro Glu Glu Gln Ile Pro Leu Phe Leu Val Phe Ser 
            20                  25                  30          


Leu Met Tyr Ala Ile Asn Ile Ser Gly Asn Leu Ala Ile Ile Thr Leu 
        35                  40                  45              


Ile Leu Ser Ala Pro Arg Leu His Ile Pro Met Tyr Ile Phe Leu Ser 
    50                  55                  60                  


Asn Leu Ala Leu Thr Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys 
65                  70                  75                  80  


Met Leu Gln Ile Ile Phe Ser Pro Thr Lys Val Ile Ser Tyr Thr Gly 
                85                  90                  95      


Cys Leu Ala Gln Thr Tyr Phe Phe Ile Cys Phe Ala Val Met Glu Asn 
            100                 105                 110         


Phe Ile Leu Ala Val Met Ala Tyr Asp Arg Tyr Ile Ala Ile Cys His 
        115                 120                 125             


Pro Phe His Tyr Thr Met Ile Leu Thr Arg Met Leu Cys Val Lys Met 
    130                 135                 140                 


Val Val Met Cys His Ala Leu Ser His Leu His Ala Met Leu His Thr 
145                 150                 155                 160 


Phe Leu Ile Gly Gln Leu Ile Phe Cys Ala Asp Asn Arg Ile Pro His 
                165                 170                 175     


Phe Phe Cys Asp Leu Tyr Ala Leu Met Lys Ile Ser Cys Thr Ser Thr 
            180                 185                 190         


Tyr Leu Asn Thr Leu Met Ile His Thr Glu Gly Ala Val Val Ile Ser 
        195                 200                 205             


Gly Ala Leu Ala Phe Ile Thr Ala Ser Tyr Ala Cys Ile Ile Leu Val 
    210                 215                 220                 


Val Leu Arg Ile Pro Ser Ala Lys Gly Arg Trp Lys Thr Phe Ser Thr 
225                 230                 235                 240 


Cys Gly Ser His Leu Thr Val Val Ala Ile Phe Tyr Gly Thr Leu Ser 
                245                 250                 255     


Trp Val Tyr Phe Arg Pro Leu Ser Ser Tyr Ser Val Thr Lys Gly Arg 
            260                 265                 270         


Ile Ile Thr Val Val Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Gly Asp Val Lys Gly Gly Phe Met Lys Trp 
    290                 295                 300                 


Met Ser Arg Met Gln Thr Phe Phe Phe Arg 
305                 310                 


<210>  3759
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  3759

Met Asn Trp Val Asn Asp Ser Ile Ile Gln Glu Phe Ile Leu Leu Gly 
1               5                   10                  15      


Phe Ser Asp Arg Pro Trp Leu Glu Phe Pro Leu Leu Val Val Phe Leu 
            20                  25                  30          


Ile Ser Tyr Thr Val Thr Ile Phe Gly Asn Leu Thr Ile Ile Leu Val 
        35                  40                  45              


Ser Arg Leu Asp Thr Lys Leu His Thr Pro Met Tyr Phe Phe Leu Thr 
    50                  55                  60                  


Asn Leu Ser Leu Leu Asp Leu Cys Tyr Thr Thr Cys Thr Val Pro Gln 
65                  70                  75                  80  


Met Leu Val Asn Leu Cys Ser Ile Arg Lys Val Ile Ser Tyr Arg Gly 
                85                  90                  95      


Cys Val Ala Gln Leu Phe Ile Phe Leu Ala Leu Gly Ala Thr Glu Tyr 
            100                 105                 110         


Leu Leu Leu Ala Val Met Ser Phe Asp Arg Phe Val Ala Ile Cys Arg 
        115                 120                 125             


Pro Leu His Tyr Ser Val Ile Met His Gln Arg Leu Cys Leu Gln Leu 
    130                 135                 140                 


Ala Ala Ala Ser Trp Val Thr Gly Phe Ser Asn Ser Val Trp Leu Ser 
145                 150                 155                 160 


Thr Leu Thr Leu Gln Leu Pro Leu Cys Asp Pro Tyr Val Ile Asp His 
                165                 170                 175     


Phe Leu Cys Glu Val Pro Ala Leu Leu Lys Leu Ser Cys Val Glu Thr 
            180                 185                 190         


Thr Ala Asn Glu Ala Glu Leu Phe Leu Val Ser Glu Leu Phe His Leu 
        195                 200                 205             


Ile Pro Leu Thr Leu Ile Leu Ile Ser Tyr Ala Phe Ile Val Arg Ala 
    210                 215                 220                 


Val Leu Arg Ile Gln Ser Ala Glu Gly Arg Gln Lys Ala Phe Gly Thr 
225                 230                 235                 240 


Cys Gly Ser His Leu Ile Val Val Ser Leu Phe Tyr Ser Thr Ala Val 
                245                 250                 255     


Ser Val Tyr Leu Gln Pro Pro Ser Pro Ser Ser Lys Asp Gln Gly Lys 
            260                 265                 270         


Met Val Ser Leu Phe Tyr Gly Ile Ile Ala Pro Met Leu Asn Pro Leu 
        275                 280                 285             


Ile Tyr Thr Leu Arg Asn Lys Glu Val Lys Glu Gly Phe Lys Arg Leu 
    290                 295                 300                 


Val Ala Arg Val Phe Leu Ile Lys Lys 
305                 310             


<210>  3760
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  3760

Met Asp Gly Val Asn Asp Ser Ser Leu Gln Gly Phe Val Leu Met Gly 
1               5                   10                  15      


Ile Ser Asp His Pro Gln Leu Glu Met Ile Phe Phe Ile Ala Ile Leu 
            20                  25                  30          


Phe Ser Tyr Leu Leu Thr Leu Leu Gly Asn Ser Thr Ile Ile Leu Leu 
        35                  40                  45              


Ser Arg Leu Glu Ala Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 
    50                  55                  60                  


Asn Leu Ser Ser Leu Asp Leu Ala Phe Ala Thr Ser Ser Val Pro Gln 
65                  70                  75                  80  


Met Leu Ile Asn Leu Trp Gly Pro Gly Lys Thr Ile Ser Tyr Gly Gly 
                85                  90                  95      


Cys Ile Thr Gln Leu Tyr Val Phe Leu Trp Leu Gly Ala Thr Glu Cys 
            100                 105                 110         


Ile Leu Leu Val Val Met Ala Phe Asp Arg Tyr Val Ala Val Cys Arg 
        115                 120                 125             


Pro Leu Arg Tyr Thr Ala Ile Met Asn Pro Gln Leu Cys Trp Leu Leu 
    130                 135                 140                 


Ala Val Ile Ala Cys Leu Gly Gly Leu Gly Asn Ser Val Ile Gln Ser 
145                 150                 155                 160 


Thr Phe Thr Leu Gln Leu Pro Leu Cys Gly His Arg Arg Val Glu Gly 
                165                 170                 175     


Phe Leu Cys Glu Val Pro Ala Met Ile Lys Leu Ala Cys Gly Asp Thr 
            180                 185                 190         


Ser Leu Asn Gln Ala Val Leu Asn Gly Val Cys Thr Phe Phe Thr Ala 
        195                 200                 205             


Val Pro Leu Ser Ile Ile Val Ile Ser Tyr Cys Leu Ile Ala Gln Ala 
    210                 215                 220                 


Val Leu Lys Ile Arg Ser Ala Glu Gly Arg Arg Lys Ala Phe Asn Thr 
225                 230                 235                 240 


Cys Leu Ser His Leu Leu Val Val Phe Leu Phe Tyr Gly Ser Ala Ser 
                245                 250                 255     


Tyr Gly Tyr Leu Leu Pro Ala Lys Asn Ser Lys Gln Asp Gln Gly Lys 
            260                 265                 270         


Phe Ile Ser Leu Phe Tyr Ser Leu Val Thr Pro Met Val Asn Pro Leu 
        275                 280                 285             


Ile Tyr Thr Leu Arg Asn Met Glu Val Lys Gly Ala Leu Arg Arg Leu 
    290                 295                 300                 


Leu Gly Lys Gly Arg Glu Val Gly 
305                 310         


<210>  3761
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  3761

Met Gly Thr Asp Asn Gln Thr Trp Val Ser Glu Phe Ile Leu Leu Gly 
1               5                   10                  15      


Leu Ser Ser Asp Trp Asp Thr Arg Val Ser Leu Phe Val Leu Phe Leu 
            20                  25                  30          


Val Met Tyr Val Val Thr Val Leu Gly Asn Cys Leu Ile Val Leu Leu 
        35                  40                  45              


Ile Arg Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Thr 
    50                  55                  60                  


Asn Leu Ser Leu Val Asp Val Ser Tyr Ala Thr Ser Val Val Pro Gln 
65                  70                  75                  80  


Leu Leu Ala His Phe Leu Ala Glu His Lys Ala Ile Pro Phe Gln Ser 
                85                  90                  95      


Cys Ala Ala Gln Leu Phe Phe Ser Leu Ala Leu Gly Gly Ile Glu Phe 
            100                 105                 110         


Val Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Val Cys Asp 
        115                 120                 125             


Ala Leu Arg Tyr Ser Ala Ile Met His Gly Gly Leu Cys Ala Arg Leu 
    130                 135                 140                 


Ala Ile Thr Ser Trp Val Ser Gly Phe Ile Ser Ser Pro Val Gln Thr 
145                 150                 155                 160 


Ala Ile Thr Phe Gln Leu Pro Met Cys Arg Asn Lys Phe Ile Asp His 
                165                 170                 175     


Ile Ser Cys Glu Leu Leu Ala Val Val Arg Leu Ala Cys Val Asp Thr 
            180                 185                 190         


Ser Ser Asn Glu Val Thr Ile Met Val Ser Ser Ile Val Leu Leu Met 
        195                 200                 205             


Thr Pro Phe Cys Leu Val Leu Leu Ser Tyr Ile Gln Ile Ile Ser Thr 
    210                 215                 220                 


Ile Leu Lys Ile Gln Ser Arg Glu Gly Arg Lys Lys Ala Phe His Thr 
225                 230                 235                 240 


Cys Ala Ser His Leu Thr Val Val Ala Leu Cys Tyr Gly Val Ala Ile 
                245                 250                 255     


Phe Thr Tyr Ile Gln Pro His Ser Ser Pro Ser Val Leu Gln Glu Lys 
            260                 265                 270         


Leu Phe Ser Val Phe Tyr Ala Ile Leu Thr Pro Met Leu Asn Pro Met 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Gly Ala Trp Gln Lys Leu 
    290                 295                 300                 


Leu Trp Lys Phe Ser Gly Leu Thr Ser Lys Leu Ala Thr 
305                 310                 315         


<210>  3762
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  3762

Met Ser Leu Gln Lys Leu Met Glu Pro Glu Ala Gly Thr Asn Arg Thr 
1               5                   10                  15      


Ala Val Ala Glu Phe Ile Leu Leu Gly Leu Val Gln Thr Glu Glu Met 
            20                  25                  30          


Gln Pro Val Val Phe Val Leu Leu Leu Phe Ala Tyr Leu Val Thr Thr 
        35                  40                  45              


Gly Gly Asn Leu Ser Ile Leu Ala Ala Val Leu Val Glu Pro Lys Leu 
    50                  55                  60                  


His Ala Pro Met Tyr Phe Phe Leu Gly Asn Leu Ser Val Leu Asp Val 
65                  70                  75                  80  


Gly Cys Ile Thr Val Thr Val Pro Ala Met Leu Gly Arg Leu Leu Ser 
                85                  90                  95      


His Lys Ser Thr Ile Ser Tyr Asp Ala Cys Leu Ser Gln Leu Phe Phe 
            100                 105                 110         


Phe His Leu Leu Ala Gly Met Asp Cys Phe Leu Leu Thr Ala Met Ala 
        115                 120                 125             


Tyr Asp Arg Leu Leu Ala Ile Cys Gln Pro Leu Thr Tyr Ser Thr Arg 
    130                 135                 140                 


Met Ser Gln Thr Val Gln Arg Met Leu Val Ala Ala Ser Trp Ala Cys 
145                 150                 155                 160 


Ala Phe Thr Asn Ala Leu Thr His Thr Val Ala Met Ser Thr Leu Asn 
                165                 170                 175     


Phe Cys Gly Pro Asn Glu Val Asn His Phe Tyr Cys Asp Leu Pro Gln 
            180                 185                 190         


Leu Phe Gln Leu Ser Cys Ser Ser Thr Gln Leu Asn Glu Leu Leu Leu 
        195                 200                 205             


Phe Val Ala Ala Ala Phe Met Ala Val Ala Pro Leu Val Phe Ile Ser 
    210                 215                 220                 


Val Ser Tyr Ala His Val Val Ala Ala Val Leu Gln Ile Arg Ser Ala 
225                 230                 235                 240 


Glu Gly Arg Lys Lys Ala Phe Ser Thr Cys Gly Ser His Leu Thr Val 
                245                 250                 255     


Val Gly Ile Phe Tyr Gly Thr Gly Val Phe Ser Tyr Met Arg Leu Gly 
            260                 265                 270         


Ser Val Glu Ser Ser Asp Lys Asp Lys Gly Val Gly Val Phe Met Thr 
        275                 280                 285             


Val Ile Asn Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Thr 
    290                 295                 300                 


Asp Val Gln Gly Ala Leu Cys Gln Leu Leu Val Gly Lys Arg Ser Leu 
305                 310                 315                 320 


Thr 
    


<210>  3763
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  3763

Met Glu Pro Gln Asn Thr Thr Gln Val Ser Met Phe Val Leu Leu Gly 
1               5                   10                  15      


Phe Ser Gln Thr Gln Glu Leu Gln Lys Phe Leu Phe Leu Leu Phe Leu 
            20                  25                  30          


Leu Val Tyr Val Thr Thr Ile Val Gly Asn Leu Leu Ile Met Val Thr 
        35                  40                  45              


Val Thr Phe Asp Cys Arg Leu His Thr Pro Met Tyr Phe Leu Leu Arg 
    50                  55                  60                  


Asn Leu Ala Leu Ile Asp Leu Cys Tyr Ser Thr Val Thr Ser Pro Lys 
65                  70                  75                  80  


Met Leu Val Asp Phe Leu His Glu Thr Lys Thr Ile Ser Tyr Gln Gly 
                85                  90                  95      


Cys Met Ala Gln Ile Phe Phe Phe His Leu Leu Gly Gly Gly Thr Val 
            100                 105                 110         


Phe Phe Leu Ser Val Met Ala Tyr Asp Arg Tyr Ile Ala Ile Ser Gln 
        115                 120                 125             


Pro Leu Arg Tyr Val Thr Ile Met Asn Thr Gln Leu Cys Val Gly Leu 
    130                 135                 140                 


Val Val Ala Ala Trp Val Gly Gly Phe Val His Ser Ile Val Gln Leu 
145                 150                 155                 160 


Ala Leu Ile Leu Pro Leu Pro Phe Cys Gly Pro Asn Ile Leu Asp Asn 
                165                 170                 175     


Phe Tyr Cys Asp Val Pro Gln Val Leu Arg Leu Ala Cys Thr Asp Thr 
            180                 185                 190         


Ser Leu Leu Glu Phe Leu Met Ile Ser Asn Ser Gly Leu Leu Val Ile 
        195                 200                 205             


Ile Trp Phe Leu Leu Leu Leu Ile Ser Tyr Thr Val Ile Leu Val Met 
    210                 215                 220                 


Leu Arg Ser His Ser Gly Lys Ala Arg Arg Lys Ala Ala Ser Thr Cys 
225                 230                 235                 240 


Thr Thr His Ile Ile Val Val Ser Met Ile Phe Ile Pro Cys Ile Tyr 
                245                 250                 255     


Ile Tyr Thr Trp Pro Phe Thr Pro Phe Leu Met Asp Lys Ala Val Ser 
            260                 265                 270         


Ile Ser Tyr Thr Val Met Thr Pro Met Leu Asn Pro Met Ile Tyr Thr 
        275                 280                 285             


Leu Arg Asn Gln Asp Met Lys Ala Ala Met Arg Arg Leu Gly Lys Cys 
    290                 295                 300                 


Leu Val Ile Cys Arg Glu 
305                 310 


<210>  3764
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  3764

Met Ser Ile Ser Asn Ile Thr Val Tyr Met Pro Ser Val Leu Thr Leu 
1               5                   10                  15      


Val Gly Ile Pro Gly Leu Glu Ser Val Gln Cys Trp Ile Gly Ile Pro 
            20                  25                  30          


Phe Cys Ala Ile Tyr Leu Ile Ala Met Ile Gly Asn Ser Leu Leu Leu 
        35                  40                  45              


Ser Ile Ile Lys Ser Glu Arg Ser Leu His Glu Pro Leu Tyr Ile Phe 
    50                  55                  60                  


Leu Gly Met Leu Gly Ala Thr Asp Ile Ala Leu Ala Ser Ser Ile Met 
65                  70                  75                  80  


Pro Lys Met Leu Gly Ile Phe Trp Phe Asn Val Pro Glu Ile Tyr Phe 
                85                  90                  95      


Asp Ser Cys Leu Leu Gln Met Trp Phe Ile His Thr Leu Gln Gly Ile 
            100                 105                 110         


Glu Ser Gly Ile Leu Val Ala Met Ala Leu Asp Arg Tyr Val Ala Ile 
        115                 120                 125             


Cys Tyr Pro Leu Arg His Ala Asn Ile Phe Thr His Gln Leu Val Ile 
    130                 135                 140                 


Gln Ile Gly Thr Met Val Val Leu Arg Ala Ala Ile Leu Val Ala Pro 
145                 150                 155                 160 


Cys Leu Val Leu Ile Lys Cys Arg Phe Gln Phe Tyr His Thr Thr Val 
                165                 170                 175     


Ile Ser His Ser Tyr Cys Glu His Met Ala Ile Val Lys Leu Ala Ala 
            180                 185                 190         


Ala Asn Val Gln Val Asn Lys Ile Tyr Gly Leu Phe Val Ala Phe Thr 
        195                 200                 205             


Val Ala Gly Phe Asp Leu Thr Phe Ile Thr Leu Ser Tyr Ile Gln Ile 
    210                 215                 220                 


Phe Ile Thr Val Phe Arg Leu Pro Gln Lys Glu Ala Arg Phe Lys Ala 
225                 230                 235                 240 


Phe Asn Thr Cys Ile Ala His Ile Cys Val Phe Leu Gln Phe Tyr Leu 
                245                 250                 255     


Leu Ala Phe Phe Ser Phe Phe Thr His Arg Phe Gly Ser His Ile Ser 
            260                 265                 270         


Pro Tyr Ile His Ile Leu Phe Ser Ser Ile Tyr Leu Leu Val Pro Pro 
        275                 280                 285             


Phe Leu Asn Pro Leu Val Tyr Gly Ala Lys Thr Thr Gln Ile Arg Ile 
    290                 295                 300                 


His Val Val Lys Met Phe Cys Ser 
305                 310         


<210>  3765
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  3765

Met Glu Arg Gly Asn Gln Thr Glu Val Gly Asn Phe Leu Leu Leu Gly 
1               5                   10                  15      


Phe Ala Glu Asp Ser Asp Met Gln Leu Leu Leu His Gly Leu Phe Leu 
            20                  25                  30          


Ser Met Tyr Leu Val Thr Ile Ile Gly Asn Leu Leu Ile Ile Leu Thr 
        35                  40                  45              


Ile Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 
    50                  55                  60                  


Asn Leu Ser Phe Ala Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys 
65                  70                  75                  80  


Met Leu Val Asn Ile Gln Thr Gln Ser Lys Met Ile Thr Phe Ala Gly 
                85                  90                  95      


Cys Leu Thr Gln Ile Phe Phe Phe Ile Ala Phe Gly Cys Leu Asp Asn 
            100                 105                 110         


Leu Leu Leu Thr Met Thr Ala Tyr Asp Arg Phe Val Ala Ile Cys Tyr 
        115                 120                 125             


Pro Leu His Tyr Thr Val Ile Met Asn Pro Arg Leu Cys Gly Leu Leu 
    130                 135                 140                 


Val Leu Gly Ser Trp Cys Ile Ser Val Met Gly Ser Leu Leu Glu Thr 
145                 150                 155                 160 


Leu Thr Ile Leu Arg Leu Ser Phe Cys Thr Asn Met Glu Ile Pro His 
                165                 170                 175     


Phe Phe Cys Asp Pro Ser Glu Val Leu Lys Leu Ala Cys Ser Asp Thr 
            180                 185                 190         


Phe Ile Asn Asn Ile Val Met Tyr Phe Val Thr Ile Val Leu Gly Val 
        195                 200                 205             


Phe Pro Leu Cys Gly Ile Leu Phe Ser Tyr Ser Gln Ile Phe Ser Ser 
    210                 215                 220                 


Val Leu Arg Val Ser Ala Arg Gly Gln His Lys Ala Phe Ser Thr Cys 
225                 230                 235                 240 


Gly Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Gly Leu Gly 
                245                 250                 255     


Val Tyr Leu Ser Ser Ala Val Thr Pro Pro Ser Arg Thr Ser Leu Ala 
            260                 265                 270         


Ala Ser Val Met Tyr Thr Met Val Thr Pro Met Leu Asn Pro Phe Ile 
        275                 280                 285             


Tyr Ser Leu Arg Asn Lys Asp Met Lys Gly Ser Leu Gly Arg Leu Leu 
    290                 295                 300                 


Leu Arg Ala Thr Ser Leu Lys Glu Gly Thr Ile Ala Lys Leu Ser 
305                 310                 315                 


<210>  3766
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  3766

Met Ala Ala Glu Asn Ser Ser Phe Val Thr Gln Phe Ile Leu Ala Gly 
1               5                   10                  15      


Leu Thr Asp Gln Pro Gly Val Gln Ile Pro Leu Phe Phe Leu Phe Leu 
            20                  25                  30          


Gly Phe Tyr Val Val Thr Val Val Gly Asn Leu Gly Leu Ile Thr Leu 
        35                  40                  45              


Ile Arg Leu Asn Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Tyr 
    50                  55                  60                  


Asn Leu Ser Phe Ile Asp Phe Cys Tyr Ser Ser Val Ile Thr Pro Lys 
65                  70                  75                  80  


Met Leu Met Ser Phe Val Leu Lys Lys Asn Ser Ile Ser Tyr Ala Gly 
                85                  90                  95      


Cys Met Thr Gln Leu Phe Phe Phe Leu Phe Phe Val Val Ser Glu Ser 
            100                 105                 110         


Phe Ile Leu Ser Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 
        115                 120                 125             


Pro Leu Leu Tyr Met Val Thr Met Ser Pro Gln Val Cys Phe Leu Leu 
    130                 135                 140                 


Leu Leu Gly Val Tyr Gly Met Gly Phe Ala Gly Ala Met Ala His Thr 
145                 150                 155                 160 


Ala Cys Met Met Gly Val Thr Phe Cys Ala Asn Asn Leu Val Asn His 
                165                 170                 175     


Tyr Met Cys Asp Ile Leu Pro Leu Leu Glu Cys Ala Cys Thr Ser Thr 
            180                 185                 190         


Tyr Val Asn Glu Leu Val Val Phe Val Val Val Gly Ile Asp Ile Gly 
        195                 200                 205             


Val Pro Thr Val Thr Ile Phe Ile Ser Tyr Ala Leu Ile Leu Ser Ser 
    210                 215                 220                 


Ile Phe His Ile Asp Ser Thr Glu Gly Arg Ser Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Ser Ser His Ile Ile Ala Val Ser Leu Phe Phe Gly Ser Gly Ala 
                245                 250                 255     


Phe Met Tyr Leu Lys Pro Phe Ser Leu Leu Ala Met Asn Gln Gly Lys 
            260                 265                 270         


Val Ser Ser Leu Phe Tyr Thr Thr Val Val Pro Met Leu Asn Pro Leu 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Val Ala Leu Lys Lys Ile 
    290                 295                 300                 


Leu Asn Lys Asn Ala Phe Ser 
305                 310     


<210>  3767
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  3767

Met Asp Ser Leu Gly Ala Val Ser Thr Arg Leu Gly Phe Asp Leu Phe 
1               5                   10                  15      


Lys Glu Leu Lys Lys Thr Asn Asp Gly Asn Ile Phe Phe Ser Pro Val 
            20                  25                  30          


Gly Ile Leu Thr Ala Ile Gly Met Val Leu Leu Gly Thr Arg Gly Ala 
        35                  40                  45              


Thr Ala Ser Gln Leu Glu Glu Val Phe His Ser Glu Lys Glu Thr Lys 
    50                  55                  60                  


Ser Ser Arg Ile Lys Ala Glu Glu Lys Glu Val Ile Glu Asn Thr Glu 
65                  70                  75                  80  


Ala Val His Gln Gln Phe Gln Lys Phe Leu Thr Glu Ile Ser Lys Leu 
                85                  90                  95      


Thr Asn Asp Tyr Glu Leu Asn Ile Thr Asn Arg Leu Phe Gly Glu Lys 
            100                 105                 110         


Thr Tyr Leu Phe Leu Gln Lys Tyr Leu Asp Tyr Val Glu Lys Tyr Tyr 
        115                 120                 125             


His Ala Ser Leu Glu Pro Val Asp Phe Val Asn Ala Ala Asp Glu Ser 
    130                 135                 140                 


Arg Lys Lys Ile Asn Ser Trp Val Glu Ser Lys Thr Asn Glu Lys Ile 
145                 150                 155                 160 


Lys Asp Leu Phe Pro Asp Gly Ser Ile Ser Ser Ser Thr Lys Leu Val 
                165                 170                 175     


Leu Val Asn Met Val Tyr Phe Lys Gly Gln Trp Asp Arg Glu Phe Lys 
            180                 185                 190         


Lys Glu Asn Thr Lys Glu Glu Lys Phe Trp Met Asn Lys Ser Thr Ser 
        195                 200                 205             


Lys Ser Val Gln Met Met Thr Gln Ser His Ser Phe Ser Phe Thr Phe 
    210                 215                 220                 


Leu Glu Asp Leu Gln Ala Lys Ile Leu Gly Ile Pro Tyr Lys Asn Asn 
225                 230                 235                 240 


Asp Leu Ser Met Phe Val Leu Leu Pro Asn Asp Ile Asp Gly Leu Glu 
                245                 250                 255     


Lys Ile Ile Asp Lys Ile Ser Pro Glu Lys Leu Val Glu Trp Thr Ser 
            260                 265                 270         


Pro Gly His Met Glu Glu Arg Lys Val Asn Leu His Leu Pro Arg Phe 
        275                 280                 285             


Glu Val Glu Asp Gly Tyr Asp Leu Glu Ala Val Leu Ala Ala Met Gly 
    290                 295                 300                 


Met Gly Asp Ala Phe Ser Glu His Lys Ala Asp Tyr Ser Gly Met Ser 
305                 310                 315                 320 


Ser Gly Ser Gly Leu Tyr Ala Gln Lys Phe Leu His Ser Ser Phe Val 
                325                 330                 335     


Ala Val Thr Glu Glu Gly Thr Glu Ala Ala Ala Ala Thr Gly Ile Gly 
            340                 345                 350         


Phe Thr Val Thr Ser Ala Pro Gly His Glu Asn Val His Cys Asn His 
        355                 360                 365             


Pro Phe Leu Phe Phe Ile Arg His Asn Glu Ser Asn Ser Ile Leu Phe 
    370                 375                 380                 


Phe Gly Arg Phe Ser Ser Pro 
385                 390     


<210>  3768
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  3768

Met Glu Leu Ala Leu Leu Cys Gly Leu Val Val Met Ala Gly Val Ile 
1               5                   10                  15      


Pro Ile Gln Gly Gly Ile Leu Asn Leu Asn Lys Met Val Lys Gln Val 
            20                  25                  30          


Thr Gly Lys Met Pro Ile Leu Ser Tyr Trp Pro Tyr Gly Cys His Cys 
        35                  40                  45              


Gly Leu Gly Gly Arg Gly Gln Pro Lys Asp Ala Thr Asp Trp Cys Cys 
    50                  55                  60                  


Gln Thr His Asp Cys Cys Tyr Asp His Leu Lys Thr Gln Gly Cys Ser 
65                  70                  75                  80  


Ile Tyr Lys Asp Tyr Tyr Arg Tyr Asn Phe Ser Gln Gly Asn Ile His 
                85                  90                  95      


Cys Ser Asp Lys Gly Ser Trp Cys Glu Gln Gln Leu Cys Ala Cys Asp 
            100                 105                 110         


Lys Glu Val Ala Phe Cys Leu Lys Arg Asn Leu Asp Thr Tyr Gln Lys 
        115                 120                 125             


Arg Leu Arg Phe Tyr Trp Arg Pro His Cys Arg Gly Gln Thr Pro Gly 
    130                 135                 140                 


Cys 
145 


<210>  3769
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  3769

Met Ala Gly Cys Ala Ala Arg Ala Pro Pro Gly Ser Glu Ala Arg Leu 
1               5                   10                  15      


Ser Leu Ala Thr Phe Leu Leu Gly Ala Ser Val Leu Ala Leu Pro Leu 
            20                  25                  30          


Leu Thr Arg Ala Gly Leu Gln Gly Arg Thr Gly Leu Ala Leu Tyr Val 
        35                  40                  45              


Ala Gly Leu Asn Ala Leu Leu Leu Leu Leu Tyr Arg Pro Pro Arg Tyr 
    50                  55                  60                  


Gln Ile Ala Ile Arg Ala Cys Phe Leu Gly Phe Val Phe Gly Cys Gly 
65                  70                  75                  80  


Thr Leu Leu Ser Phe Ser Gln Ser Ser Trp Ser His Phe Gly Trp Tyr 
                85                  90                  95      


Met Cys Ser Leu Ser Leu Phe His Tyr Ser Glu Tyr Leu Val Thr Ala 
            100                 105                 110         


Val Asn Asn Pro Lys Ser Leu Ser Leu Asp Ser Phe Leu Leu Asn His 
        115                 120                 125             


Ser Leu Glu Tyr Thr Val Ala Ala Leu Ser Ser Trp Leu Glu Phe Thr 
    130                 135                 140                 


Leu Glu Asn Ile Phe Trp Pro Glu Leu Lys Gln Ile Thr Trp Leu Ser 
145                 150                 155                 160 


Val Thr Gly Leu Leu Met Val Val Phe Gly Glu Cys Leu Arg Lys Ala 
                165                 170                 175     


Ala Met Phe Thr Ala Gly Ser Asn Phe Asn His Val Val Gln Asn Glu 
            180                 185                 190         


Lys Ser Asp Thr His Thr Leu Val Thr Ser Gly Val Tyr Ala Trp Phe 
        195                 200                 205             


Arg His Pro Ser Tyr Val Gly Trp Phe Tyr Trp Ser Ile Gly Thr Gln 
    210                 215                 220                 


Val Met Leu Cys Asn Pro Ile Cys Gly Val Ser Tyr Ala Leu Thr Val 
225                 230                 235                 240 


Trp Arg Phe Phe Arg Asp Arg Thr Glu Glu Glu Glu Ile Ser Leu Ile 
                245                 250                 255     


His Phe Phe Gly Glu Glu Tyr Leu Glu Tyr Lys Lys Arg Val Pro Thr 
            260                 265                 270         


Gly Leu Pro Phe Ile Lys Gly Val Lys Val Asp Leu 
        275                 280                 


<210>  3770
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  3770

Met Phe Ala Asp Leu Asp Tyr Asp Ile Glu Glu Asp Lys Leu Gly Ile 
1               5                   10                  15      


Pro Thr Val Pro Gly Lys Val Thr Leu Gln Lys Asp Ala Gln Asn Leu 
            20                  25                  30          


Ile Gly Ile Ser Ile Gly Gly Gly Ala Gln Tyr Cys Pro Cys Leu Tyr 
        35                  40                  45              


Ile Val Gln Val Phe Asp Asn Thr Pro Ala Ala Leu Asp Gly Thr Val 
    50                  55                  60                  


Ala Ala Gly Asp Glu Ile Thr Gly Val Asn Gly Arg Ser Ile Lys Gly 
65                  70                  75                  80  


Lys Thr Lys Val Glu Val Ala Lys Met Ile Gln Glu Val Lys Gly Glu 
                85                  90                  95      


Val Thr Ile His Tyr Asn Lys Leu Gln Ala Asp Pro Lys Gln Gly Met 
            100                 105                 110         


Ser Leu Asp Ile Val Leu Lys Lys Val Lys His Arg Leu Val Glu Asn 
        115                 120                 125             


Met Ser Ser Gly Thr Ala Asp Ala Leu Gly Leu Ser Arg Ala Ile Leu 
    130                 135                 140                 


Cys Asn Asp Gly Leu Val Lys Arg Leu Glu Glu Leu Glu Arg Thr Ala 
145                 150                 155                 160 


Glu Leu Tyr Lys Gly Met Thr Glu His Thr Lys Asn Leu Leu Arg Ala 
                165                 170                 175     


Phe Tyr Glu Leu Ser Gln Thr His Arg Ala Phe Gly Asp Val Phe Ser 
            180                 185                 190         


Val Ile Gly Val Arg Glu Pro Gln Pro Ala Ala Ser Glu Ala Phe Val 
        195                 200                 205             


Lys Phe Ala Asp Ala His Arg Ser Ile Glu Lys Phe Gly Ile Arg Leu 
    210                 215                 220                 


Leu Lys Thr Ile Lys Pro Met Leu Thr Asp Leu Asn Thr Tyr Leu Asn 
225                 230                 235                 240 


Lys Ala Ile Pro Asp Thr Arg Leu Thr Ile Lys Lys Tyr Leu Asp Val 
                245                 250                 255     


Lys Phe Glu Tyr Leu Ser Tyr Cys Leu Lys Val Lys Glu Met Asp Asp 
            260                 265                 270         


Glu Glu Tyr Ser Cys Ile Ala Leu Gly Glu Pro Leu Tyr Arg Val Ser 
        275                 280                 285             


Thr Gly Asn Tyr Glu Tyr Arg Leu Ile Leu Arg Cys Arg Gln Glu Ala 
    290                 295                 300                 


Arg Ala Arg Phe Ser Gln Met Arg Lys Asp Val Leu Glu Lys Met Glu 
305                 310                 315                 320 


Leu Leu Asp Gln Lys His Val Gln Asp Ile Val Phe Gln Leu Gln Arg 
                325                 330                 335     


Leu Val Ser Thr Met Ser Lys Tyr Tyr Asn Asp Cys Tyr Ala Val Leu 
            340                 345                 350         


Arg Asp Ala Asp Val Phe Pro Ile Glu Val Asp Leu Ala His Thr Thr 
        355                 360                 365             


Leu Ala Tyr Gly Leu Asn Gln Glu Glu Phe Thr Asp Gly Glu Glu Glu 
    370                 375                 380                 


Glu Glu Glu Glu Asp Thr Ala Ala Gly Glu Pro Ser Arg Asp Thr Arg 
385                 390                 395                 400 


Gly Ala Ala Gly Pro Leu Asp Lys Gly Gly Ser Trp Cys Asp Ser 
                405                 410                 415 


<210>  3771
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  3771

Met Arg Lys His Leu Ser Trp Trp Trp Leu Ala Thr Val Cys Met Leu 
1               5                   10                  15      


Leu Phe Ser His Leu Ser Ala Val Gln Thr Arg Gly Ile Lys His Arg 
            20                  25                  30          


Ile Lys Trp Asn Arg Lys Ala Leu Pro Ser Thr Ala Gln Ile Thr Glu 
        35                  40                  45              


Ala Gln Val Ala Glu Asn Arg Pro Gly Ala Phe Ile Lys Gln Gly Arg 
    50                  55                  60                  


Lys Leu Asp Ile Asp Phe Gly Ala Glu Gly Asn Arg Tyr Tyr Glu Ala 
65                  70                  75                  80  


Asn Tyr Trp Gln Phe Pro Asp Gly Ile His Tyr Asn Gly Cys Ser Glu 
                85                  90                  95      


Ala Asn Val Thr Lys Glu Ala Phe Val Thr Gly Cys Ile Asn Ala Thr 
            100                 105                 110         


Gln Ala Ala Asn Gln Gly Glu Phe Gln Lys Pro Asp Asn Lys Leu His 
        115                 120                 125             


Gln Gln Val Leu Trp Arg Leu Val Gln Glu Leu Cys Ser Leu Lys His 
    130                 135                 140                 


Cys Glu Phe Trp Leu Glu Arg Gly Ala Gly Leu Arg Val Thr Met His 
145                 150                 155                 160 


Gln Pro Val Leu Leu Cys Leu Leu Ala Leu Ile Trp Leu Thr Val Lys 
                165                 170                 175     


<210>  3772
<211>  853
<212>  PRT
<213>  Homo sapiens

<400>  3772

Met Gly Thr Pro Arg Ala Gln His Pro Pro Pro Pro Gln Leu Leu Phe 
1               5                   10                  15      


Leu Ile Leu Leu Ser Cys Pro Trp Ile Gln Gly Leu Pro Leu Lys Glu 
            20                  25                  30          


Glu Glu Ile Leu Pro Glu Pro Gly Ser Glu Thr Pro Thr Val Ala Ser 
        35                  40                  45              


Glu Ala Leu Ala Glu Leu Leu His Gly Ala Leu Leu Arg Arg Gly Pro 
    50                  55                  60                  


Glu Met Gly Tyr Leu Pro Gly Pro Pro Leu Gly Pro Glu Gly Gly Glu 
65                  70                  75                  80  


Glu Glu Thr Thr Thr Thr Ile Ile Thr Thr Thr Thr Val Thr Thr Thr 
                85                  90                  95      


Val Thr Ser Pro Val Leu Cys Asn Asn Asn Ile Ser Glu Gly Glu Gly 
            100                 105                 110         


Tyr Val Glu Ser Pro Asp Leu Gly Ser Pro Val Ser Arg Thr Leu Gly 
        115                 120                 125             


Leu Leu Asp Cys Thr Tyr Ser Ile His Val Tyr Pro Gly Tyr Gly Ile 
    130                 135                 140                 


Glu Ile Gln Val Gln Thr Leu Asn Leu Ser Gln Glu Glu Glu Leu Leu 
145                 150                 155                 160 


Val Leu Ala Gly Gly Gly Ser Pro Gly Leu Ala Pro Arg Leu Leu Ala 
                165                 170                 175     


Asn Ser Ser Met Leu Gly Glu Gly Gln Val Leu Arg Ser Pro Thr Asn 
            180                 185                 190         


Arg Leu Leu Leu His Phe Gln Ser Pro Arg Val Pro Arg Gly Gly Gly 
        195                 200                 205             


Phe Arg Ile His Tyr Gln Ala Tyr Leu Leu Ser Cys Gly Phe Pro Pro 
    210                 215                 220                 


Arg Pro Ala His Gly Asp Val Ser Val Thr Asp Leu His Pro Gly Gly 
225                 230                 235                 240 


Thr Ala Thr Phe His Cys Asp Ser Gly Tyr Gln Leu Gln Gly Glu Glu 
                245                 250                 255     


Thr Leu Ile Cys Leu Asn Gly Thr Arg Pro Ser Trp Asn Gly Glu Thr 
            260                 265                 270         


Pro Ser Cys Met Ala Ser Cys Gly Gly Thr Ile His Asn Ala Thr Leu 
        275                 280                 285             


Gly Arg Ile Val Ser Pro Glu Pro Gly Gly Ala Val Gly Pro Asn Leu 
    290                 295                 300                 


Thr Cys Arg Trp Val Ile Glu Ala Ala Glu Gly Arg Arg Leu His Leu 
305                 310                 315                 320 


His Phe Glu Arg Val Ser Leu Asp Glu Asp Asn Asp Arg Leu Met Val 
                325                 330                 335     


Arg Ser Gly Gly Ser Pro Leu Ser Pro Val Ile Tyr Asp Ser Asp Met 
            340                 345                 350         


Asp Asp Val Pro Glu Arg Gly Leu Ile Ser Asp Ala Gln Ser Leu Tyr 
        355                 360                 365             


Val Glu Leu Leu Ser Glu Thr Pro Ala Asn Pro Leu Leu Leu Ser Leu 
    370                 375                 380                 


Arg Phe Glu Ala Phe Glu Glu Asp Arg Cys Phe Ala Pro Phe Leu Ala 
385                 390                 395                 400 


His Gly Asn Val Thr Thr Thr Asp Pro Glu Tyr Arg Pro Gly Ala Leu 
                405                 410                 415     


Ala Thr Phe Ser Cys Leu Pro Gly Tyr Ala Leu Glu Pro Pro Gly Pro 
            420                 425                 430         


Pro Asn Ala Ile Glu Cys Val Asp Pro Thr Glu Pro His Trp Asn Asp 
        435                 440                 445             


Thr Glu Pro Ala Cys Lys Ala Met Cys Gly Gly Glu Leu Ser Glu Pro 
    450                 455                 460                 


Ala Gly Val Val Leu Ser Pro Asp Trp Pro Gln Ser Tyr Ser Pro Gly 
465                 470                 475                 480 


Gln Asp Cys Val Trp Gly Val His Val Gln Glu Glu Lys Arg Ile Leu 
                485                 490                 495     


Leu Gln Val Glu Ile Leu Asn Val Arg Glu Gly Asp Met Leu Thr Leu 
            500                 505                 510         


Phe Asp Gly Asp Gly Pro Ser Ala Arg Val Leu Ala Gln Leu Arg Gly 
        515                 520                 525             


Pro Gln Pro Arg Arg Arg Leu Leu Ser Ser Gly Pro Asp Leu Thr Leu 
    530                 535                 540                 


Gln Phe Gln Ala Pro Pro Gly Pro Pro Asn Pro Gly Leu Gly Gln Gly 
545                 550                 555                 560 


Phe Val Leu His Phe Lys Glu Val Pro Arg Asn Asp Thr Cys Pro Glu 
                565                 570                 575     


Leu Pro Pro Pro Glu Trp Gly Trp Arg Thr Ala Ser His Gly Asp Leu 
            580                 585                 590         


Ile Arg Gly Thr Val Leu Thr Tyr Gln Cys Glu Pro Gly Tyr Glu Leu 
        595                 600                 605             


Leu Gly Ser Asp Ile Leu Thr Cys Gln Trp Asp Leu Ser Trp Ser Ala 
    610                 615                 620                 


Ala Pro Pro Ala Cys Gln Lys Ile Met Thr Cys Ala Asp Pro Gly Glu 
625                 630                 635                 640 


Ile Ala Asn Gly His Arg Thr Ala Ser Asp Ala Gly Phe Pro Val Gly 
                645                 650                 655     


Ser His Val Gln Tyr Arg Cys Leu Pro Gly Tyr Ser Leu Glu Gly Ala 
            660                 665                 670         


Ala Met Leu Thr Cys Tyr Ser Arg Asp Thr Gly Thr Pro Lys Trp Ser 
        675                 680                 685             


Asp Arg Val Pro Lys Cys Ala Leu Lys Tyr Glu Pro Cys Leu Asn Pro 
    690                 695                 700                 


Gly Val Pro Glu Asn Gly Tyr Gln Thr Leu Tyr Lys His His Tyr Gln 
705                 710                 715                 720 


Ala Gly Glu Ser Leu Arg Phe Phe Cys Tyr Glu Gly Phe Glu Leu Ile 
                725                 730                 735     


Gly Glu Val Thr Ile Thr Cys Val Pro Gly His Pro Ser Gln Trp Thr 
            740                 745                 750         


Ser Gln Pro Pro Leu Cys Lys Val Ala Tyr Glu Glu Leu Leu Asp Asn 
        755                 760                 765             


Arg Lys Leu Glu Val Thr Gln Thr Thr Asp Pro Ser Arg Gln Leu Glu 
    770                 775                 780                 


Gly Gly Asn Leu Ala Leu Ala Ile Leu Leu Pro Leu Gly Leu Val Ile 
785                 790                 795                 800 


Val Leu Gly Ser Gly Val Tyr Ile Tyr Tyr Thr Lys Leu Gln Gly Lys 
                805                 810                 815     


Ser Leu Phe Gly Phe Ser Gly Ser His Ser Tyr Ser Pro Ile Thr Val 
            820                 825                 830         


Glu Ser Asp Phe Ser Asn Pro Leu Tyr Glu Ala Gly Asp Thr Arg Glu 
        835                 840                 845             


Tyr Glu Val Ser Ile 
    850             


<210>  3773
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  3773

Met Ala Thr Ala Arg Pro Pro Trp Met Trp Val Leu Cys Ala Leu Ile 
1               5                   10                  15      


Thr Ala Leu Leu Leu Gly Val Thr Glu His Val Leu Ala Asn Asn Asp 
            20                  25                  30          


Val Ser Cys Asp His Pro Ser Asn Thr Val Pro Ser Gly Ser Asn Gln 
        35                  40                  45              


Asp Leu Gly Ala Gly Ala Gly Glu Asp Ala Arg Ser Asp Asp Ser Ser 
    50                  55                  60                  


Ser Arg Ile Ile Asn Gly Ser Asp Cys Asp Met His Thr Gln Pro Trp 
65                  70                  75                  80  


Gln Ala Ala Leu Leu Leu Arg Pro Asn Gln Leu Tyr Cys Gly Ala Val 
                85                  90                  95      


Leu Val His Pro Gln Trp Leu Leu Thr Ala Ala His Cys Arg Lys Lys 
            100                 105                 110         


Val Phe Arg Val Arg Leu Gly His Tyr Ser Leu Ser Pro Val Tyr Glu 
        115                 120                 125             


Ser Gly Gln Gln Met Phe Gln Gly Val Lys Ser Ile Pro His Pro Gly 
    130                 135                 140                 


Tyr Ser His Pro Gly His Ser Asn Asp Leu Met Leu Ile Lys Leu Asn 
145                 150                 155                 160 


Arg Arg Ile Arg Pro Thr Lys Asp Val Arg Pro Ile Asn Val Ser Ser 
                165                 170                 175     


His Cys Pro Ser Ala Gly Thr Lys Cys Leu Val Ser Gly Trp Gly Thr 
            180                 185                 190         


Thr Lys Ser Pro Gln Val His Phe Pro Lys Val Leu Gln Cys Leu Asn 
        195                 200                 205             


Ile Ser Val Leu Ser Gln Lys Arg Cys Glu Asp Ala Tyr Pro Arg Gln 
    210                 215                 220                 


Ile Asp Asp Thr Met Phe Cys Ala Gly Asp Lys Ala Gly Arg Asp Ser 
225                 230                 235                 240 


Cys Gln Gly Asp Ser Gly Gly Pro Val Val Cys Asn Gly Ser Leu Gln 
                245                 250                 255     


Gly Leu Val Ser Trp Gly Asp Tyr Pro Cys Ala Arg Pro Asn Arg Pro 
            260                 265                 270         


Gly Val Tyr Thr Asn Leu Cys Lys Phe Thr Lys Trp Ile Gln Glu Thr 
        275                 280                 285             


Ile Gln Ala Asn Ser 
    290             


<210>  3774
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  3774

Met Ser Gly Ser Ser Leu Pro Ser Ala Leu Ala Leu Ser Leu Leu Leu 
1               5                   10                  15      


Val Ser Gly Ser Leu Leu Pro Gly Pro Gly Ala Ala Gln Asn Ala Gly 
            20                  25                  30          


Phe Val Lys Ser Pro Met Ser Glu Thr Lys Leu Thr Gly Asp Ala Phe 
        35                  40                  45              


Glu Leu Tyr Cys Asp Val Val Gly Ser Pro Thr Pro Glu Ile Gln Trp 
    50                  55                  60                  


Trp Tyr Ala Glu Val Asn Arg Ala Glu Ser Phe Arg Gln Leu Trp Asp 
65                  70                  75                  80  


Gly Ala Arg Lys Arg Arg Val Thr Val Asn Thr Ala Tyr Gly Ser Asn 
                85                  90                  95      


Gly Val Ser Val Leu Arg Ile Thr Arg Leu Thr Leu Glu Asp Ser Gly 
            100                 105                 110         


Thr Tyr Glu Cys Arg Ala Ser Asn Asp Pro Lys Arg Asn Asp Leu Arg 
        115                 120                 125             


Gln Asn Pro Ser Ile Thr Trp Ile Arg Ala Gln Ala Thr Ile Ser Val 
    130                 135                 140                 


Leu Gln Lys Pro Arg Ile Val Thr Ser Glu Glu Val Ile Ile Arg Asp 
145                 150                 155                 160 


Ser Pro Val Leu Pro Val Thr Leu Gln Cys Asn Leu Thr Ser Ser Ser 
                165                 170                 175     


His Thr Leu Thr Tyr Ser Tyr Trp Thr Lys Asn Gly Val Glu Leu Ser 
            180                 185                 190         


Ala Thr Arg Lys Asn Ala Ser Asn Met Glu Tyr Arg Ile Asn Lys Pro 
        195                 200                 205             


Arg Ala Glu Asp Ser Gly Glu Tyr His Cys Val Tyr His Phe Val Ser 
    210                 215                 220                 


Ala Pro Lys Ala Asn Ala Thr Ile Glu Val Lys Ala Ala Pro Asp Ile 
225                 230                 235                 240 


Thr Gly His Lys Arg Ser Glu Asn Lys Asn Glu Gly Gln Asp Ala Thr 
                245                 250                 255     


Met Tyr Cys Lys Ser Val Gly Tyr Pro His Pro Asp Trp Ile Trp Arg 
            260                 265                 270         


Lys Lys Glu Asn Gly Met Pro Met Asp Ile Val Asn Thr Ser Gly Arg 
        275                 280                 285             


Phe Phe Ile Ile Asn Lys Glu Asn Tyr Thr Glu Leu Asn Ile Val Asn 
    290                 295                 300                 


Leu Gln Ile Thr Glu Asp Pro Gly Glu Tyr Glu Cys Asn Ala Thr Asn 
305                 310                 315                 320 


Ala Ile Gly Ser Ala Ser Val Val Thr Val Leu Arg Val Arg Ser His 
                325                 330                 335     


Leu Ala Pro Leu Trp Pro Phe Leu Gly Ile Leu Ala Glu Ile Ile Ile 
            340                 345                 350         


Leu Val Val Ile Ile Val Val Tyr Glu Lys Arg Lys Arg Pro Asp Glu 
        355                 360                 365             


Val Pro Asp Asp Asp Glu Pro Ala Gly Pro Met Lys Thr Asn Ser Thr 
    370                 375                 380                 


Asn Asn His Lys Asp Lys Asn Leu Arg Gln Arg Asn Thr Asn 
385                 390                 395             


<210>  3775
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  3775

Met Ser Met Ile Leu Ser Ala Ser Val Ile Arg Val Arg Asp Gly Leu 
1               5                   10                  15      


Pro Leu Ser Ala Ser Thr Asp Tyr Glu Gln Ser Thr Gly Met Gln Glu 
            20                  25                  30          


Cys Arg Lys Tyr Phe Lys Met Leu Ser Arg Lys Leu Ala Gln Leu Pro 
        35                  40                  45              


Asp Arg Cys Thr Leu Lys Thr Gly His Tyr Asn Ile Asn Phe Ile Ser 
    50                  55                  60                  


Ser Leu Gly Val Ser Tyr Met Met Leu Cys Thr Glu Asn Tyr Pro Asn 
65                  70                  75                  80  


Val Leu Ala Phe Ser Phe Leu Asp Glu Leu Gln Lys Glu Phe Ile Thr 
                85                  90                  95      


Thr Tyr Asn Met Met Lys Thr Asn Thr Ala Val Arg Pro Tyr Cys Phe 
            100                 105                 110         


Ile Glu Phe Asp Asn Phe Ile Gln Arg Thr Lys Gln Arg Tyr Asn Asn 
        115                 120                 125             


Pro Arg Ser Leu Ser Thr Lys Ile Asn Leu Ser Asp Met Gln Thr Glu 
    130                 135                 140                 


Ile Lys Leu Arg Pro Pro Tyr Gln Ile Ser Met Cys Glu Leu Gly Ser 
145                 150                 155                 160 


Ala Asn Gly Val Thr Ser Ala Phe Ser Val Asp Cys Lys Gly Ala Gly 
                165                 170                 175     


Lys Ile Ser Ser Ala His Gln Arg Leu Glu Pro Ala Thr Leu Ser Gly 
            180                 185                 190         


Ile Val Gly Phe Ile Leu Ser Leu Leu Cys Gly Ala Leu Asn Leu Ile 
        195                 200                 205             


Arg Gly Phe His Ala Ile Glu Ser Leu Leu Gln Ser Asp Gly Asp Asp 
    210                 215                 220                 


Phe Asn Tyr Ile Ile Ala Phe Phe Leu Gly Thr Ala Ala Cys Leu Tyr 
225                 230                 235                 240 


Gln Cys Tyr Leu Leu Val Tyr Tyr Thr Gly Trp Arg Asn Val Lys Ser 
                245                 250                 255     


Phe Leu Thr Phe Gly Leu Ile Cys Leu Cys Asn Met Tyr Leu Tyr Glu 
            260                 265                 270         


Leu Arg Asn Leu Trp Gln Leu Phe Phe His Val Thr Val Gly Ala Phe 
        275                 280                 285             


Val Thr Leu Gln Ile Trp Leu Arg Gln Ala Gln Gly Lys Ala Pro Asp 
    290                 295                 300                 


Tyr Asp Val 
305         


<210>  3776
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  3776

Met Arg Ser Pro Val Arg Asp Leu Ala Arg Asn Asp Gly Glu Glu Ser 
1               5                   10                  15      


Thr Asp Arg Thr Pro Leu Leu Pro Gly Ala Pro Arg Ala Glu Ala Ala 
            20                  25                  30          


Pro Val Cys Cys Ser Ala Arg Tyr Asn Leu Ala Ile Leu Ala Phe Phe 
        35                  40                  45              


Gly Phe Phe Ile Val Tyr Ala Leu Arg Val Asn Leu Ser Val Ala Leu 
    50                  55                  60                  


Val Asp Met Val Asp Ser Asn Thr Thr Leu Glu Asp Asn Arg Thr Ser 
65                  70                  75                  80  


Lys Ala Cys Pro Glu His Ser Ala Pro Ile Lys Val His His Asn Gln 
                85                  90                  95      


Thr Gly Lys Lys Tyr Gln Trp Asp Ala Glu Thr Gln Gly Trp Ile Leu 
            100                 105                 110         


Gly Ser Phe Phe Tyr Gly Tyr Ile Ile Thr Gln Ile Pro Gly Gly Tyr 
        115                 120                 125             


Val Ala Ser Lys Ile Gly Gly Lys Met Leu Leu Gly Phe Gly Ile Leu 
    130                 135                 140                 


Gly Thr Ala Val Leu Thr Leu Phe Thr Pro Ile Ala Ala Asp Leu Gly 
145                 150                 155                 160 


Val Gly Pro Leu Ile Val Leu Arg Ala Leu Glu Gly Leu Gly Glu Gly 
                165                 170                 175     


Val Thr Phe Pro Ala Met His Ala Met Trp Ser Ser Trp Ala Pro Pro 
            180                 185                 190         


Leu Glu Arg Ser Lys Leu Leu Ser Ile Ser Tyr Ala Gly Ala Gln Leu 
        195                 200                 205             


Gly Thr Val Ile Ser Leu Pro Leu Ser Gly Ile Ile Cys Tyr Tyr Met 
    210                 215                 220                 


Asn Trp Thr Tyr Val Phe Tyr Phe Phe Gly Thr Ile Gly Ile Phe Trp 
225                 230                 235                 240 


Phe Leu Leu Trp Ile Trp Leu Val Ser Asp Thr Pro Gln Lys His Lys 
                245                 250                 255     


Arg Ile Ser His Tyr Glu Lys Glu Tyr Ile Leu Ser Ser Leu Arg Asn 
            260                 265                 270         


Gln Leu Ser Ser Gln Lys Ser Val Pro Trp Val Pro Ile Leu Lys Ser 
        275                 280                 285             


Leu Pro Leu Trp Ala Ile Val Val Ala His Phe Ser Tyr Asn Trp Thr 
    290                 295                 300                 


Phe Tyr Thr Leu Leu Thr Leu Leu Pro Thr Tyr Met Lys Glu Ile Leu 
305                 310                 315                 320 


Arg Phe Asn Val Gln Glu Asn Gly Phe Leu Ser Ser Leu Pro Tyr Leu 
                325                 330                 335     


Gly Ser Trp Leu Cys Met Ile Leu Ser Gly Gln Ala Ala Asp Asn Leu 
            340                 345                 350         


Arg Ala Lys Trp Asn Phe Ser Thr Leu Cys Val Arg Arg Ile Phe Ser 
        355                 360                 365             


Leu Ile Gly Met Ile Gly Pro Ala Val Phe Leu Val Ala Ala Gly Phe 
    370                 375                 380                 


Ile Gly Cys Asp Tyr Ser Leu Ala Val Ala Phe Leu Thr Ile Ser Thr 
385                 390                 395                 400 


Thr Leu Gly Gly Phe Cys Ser Ser Gly Phe Ser Ile Asn His Leu Asp 
                405                 410                 415     


Ile Ala Pro Ser Tyr Ala Gly Ile Leu Leu Gly Ile Thr Asn Thr Phe 
            420                 425                 430         


Ala Thr Ile Pro Gly Met Val Gly Pro Val Ile Ala Lys Ser Leu Thr 
        435                 440                 445             


Pro Asp Asn Thr Val Gly Glu Trp Gln Thr Val Phe Tyr Ile Ala Ala 
    450                 455                 460                 


Ala Ile Asn Val Phe Gly Ala Ile Phe Phe Thr Leu Phe Ala Lys Gly 
465                 470                 475                 480 


Glu Val Gln Asn Trp Ala Leu Asn Asp His His Gly His Arg His 
                485                 490                 495 


<210>  3777
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  3777

Met Glu Ser Arg Lys Asp Ile Thr Asn Gln Glu Glu Leu Trp Lys Met 
1               5                   10                  15      


Lys Pro Arg Arg Asn Leu Glu Glu Asp Asp Tyr Leu His Lys Asp Thr 
            20                  25                  30          


Gly Glu Thr Ser Met Leu Lys Arg Pro Val Leu Leu His Leu His Gln 
        35                  40                  45              


Thr Ala His Ala Asp Glu Phe Asp Cys Pro Ser Glu Leu Gln His Thr 
    50                  55                  60                  


Gln Glu Leu Phe Pro Gln Trp His Leu Pro Ile Lys Ile Ala Ala Ile 
65                  70                  75                  80  


Ile Ala Ser Leu Thr Phe Leu Tyr Thr Leu Leu Arg Glu Val Ile His 
                85                  90                  95      


Pro Leu Ala Thr Ser His Gln Gln Tyr Phe Tyr Lys Ile Pro Ile Leu 
            100                 105                 110         


Val Ile Asn Lys Val Leu Pro Met Val Ser Ile Thr Leu Leu Ala Leu 
        115                 120                 125             


Val Tyr Leu Pro Gly Val Ile Ala Ala Ile Val Gln Leu His Asn Gly 
    130                 135                 140                 


Thr Lys Tyr Lys Lys Phe Pro His Trp Leu Asp Lys Trp Met Leu Thr 
145                 150                 155                 160 


Arg Lys Gln Phe Gly Leu Leu Ser Phe Phe Phe Ala Val Leu His Ala 
                165                 170                 175     


Ile Tyr Ser Leu Ser Tyr Pro Met Arg Arg Ser Tyr Arg Tyr Lys Leu 
            180                 185                 190         


Leu Asn Trp Ala Tyr Gln Gln Val Gln Gln Asn Lys Glu Asp Ala Trp 
        195                 200                 205             


Ile Glu His Asp Val Trp Arg Met Glu Ile Tyr Val Ser Leu Gly Ile 
    210                 215                 220                 


Val Gly Leu Ala Ile Leu Ala Leu Leu Ala Val Thr Ser Ile Pro Ser 
225                 230                 235                 240 


Val Ser Asp Ser Leu Thr Trp Arg Glu Phe His Tyr Ile Gln Ser Lys 
                245                 250                 255     


Leu Gly Ile Val Ser Leu Leu Leu Gly Thr Ile His Ala Leu Ile Phe 
            260                 265                 270         


Ala Trp Asn Lys Trp Ile Asp Ile Lys Gln Phe Val Trp Tyr Thr Pro 
        275                 280                 285             


Pro Thr Phe Met Ile Ala Val Phe Leu Pro Ile Val Val Leu Ile Phe 
    290                 295                 300                 


Lys Ser Ile Leu Phe Leu Pro Cys Leu Arg Lys Lys Ile Leu Lys Ile 
305                 310                 315                 320 


Arg His Gly Trp Glu Asp Val Thr Lys Ile Asn Lys Thr Glu Ile Cys 
                325                 330                 335     


Ser Gln Leu 
            


<210>  3778
<211>  626
<212>  PRT
<213>  Homo sapiens

<400>  3778

Met Gly Leu Leu Gln Gly Leu Leu Arg Val Arg Lys Leu Leu Leu Val 
1               5                   10                  15      


Val Cys Val Pro Leu Leu Leu Leu Pro Leu Pro Val Leu His Pro Ser 
            20                  25                  30          


Ser Glu Ala Ser Cys Ala Tyr Val Leu Ile Val Thr Ala Val Tyr Trp 
        35                  40                  45              


Val Ser Glu Ala Val Pro Leu Gly Ala Ala Ala Leu Val Pro Ala Phe 
    50                  55                  60                  


Leu Tyr Pro Phe Phe Gly Val Leu Arg Ser Asn Glu Val Ala Ala Glu 
65                  70                  75                  80  


Tyr Phe Lys Asn Thr Thr Leu Leu Leu Val Gly Val Ile Cys Val Ala 
                85                  90                  95      


Ala Ala Val Glu Lys Trp Asn Leu His Lys Arg Ile Ala Leu Arg Met 
            100                 105                 110         


Val Leu Met Ala Gly Ala Lys Pro Gly Met Leu Leu Leu Cys Phe Met 
        115                 120                 125             


Cys Cys Thr Thr Leu Leu Ser Met Trp Leu Ser Asn Thr Ser Thr Thr 
    130                 135                 140                 


Ala Met Val Met Pro Ile Val Glu Ala Val Leu Gln Glu Leu Val Ser 
145                 150                 155                 160 


Ala Glu Asp Glu Gln Leu Val Ala Gly Asn Ser Asn Thr Glu Glu Ala 
                165                 170                 175     


Glu Pro Ile Ser Leu Asp Val Lys Asn Ser Gln Pro Ser Leu Glu Leu 
            180                 185                 190         


Ile Phe Val Asn Glu Glu Ser Asn Ala Asp Leu Thr Thr Leu Met His 
        195                 200                 205             


Asn Glu Asn Leu Asn Gly Val Pro Ser Ile Thr Asn Pro Ile Lys Thr 
    210                 215                 220                 


Ala Asn Gln His Gln Gly Lys Lys Gln His Pro Ser Gln Glu Lys Pro 
225                 230                 235                 240 


Gln Val Leu Thr Pro Ser Pro Arg Lys Gln Lys Leu Asn Arg Lys Tyr 
                245                 250                 255     


Arg Ser His His Asp Gln Met Ile Cys Lys Cys Leu Ser Leu Ser Ile 
            260                 265                 270         


Ser Tyr Ser Ala Thr Ile Gly Gly Leu Thr Thr Ile Ile Gly Thr Ser 
        275                 280                 285             


Thr Ser Leu Ile Phe Leu Glu His Phe Asn Asn Gln Tyr Pro Ala Ala 
    290                 295                 300                 


Glu Val Val Asn Phe Gly Thr Trp Phe Leu Phe Ser Phe Pro Ile Ser 
305                 310                 315                 320 


Leu Ile Met Leu Val Val Ser Trp Phe Trp Met His Trp Leu Phe Leu 
                325                 330                 335     


Gly Cys Asn Phe Lys Glu Thr Cys Ser Leu Ser Lys Lys Lys Lys Thr 
            340                 345                 350         


Lys Arg Glu Gln Leu Ser Glu Lys Arg Ile Gln Glu Glu Tyr Glu Lys 
        355                 360                 365             


Leu Gly Asp Ile Ser Tyr Pro Glu Met Val Thr Gly Phe Phe Phe Ile 
    370                 375                 380                 


Leu Met Thr Val Leu Trp Phe Thr Arg Glu Pro Gly Phe Val Pro Gly 
385                 390                 395                 400 


Trp Asp Ser Phe Phe Glu Lys Lys Gly Tyr Arg Thr Asp Ala Thr Val 
                405                 410                 415     


Ser Val Phe Leu Gly Phe Leu Leu Phe Leu Ile Pro Ala Lys Lys Pro 
            420                 425                 430         


Cys Phe Gly Lys Lys Asn Asp Gly Glu Asn Gln Glu His Ser Leu Gly 
        435                 440                 445             


Thr Glu Pro Ile Ile Thr Trp Lys Asp Phe Gln Lys Thr Met Pro Trp 
    450                 455                 460                 


Glu Ile Val Ile Leu Val Gly Gly Gly Tyr Ala Leu Ala Ser Gly Ser 
465                 470                 475                 480 


Lys Ser Ser Gly Leu Ser Thr Trp Ile Gly Asn Gln Met Leu Ser Leu 
                485                 490                 495     


Ser Ser Leu Pro Pro Trp Ala Val Thr Leu Leu Ala Cys Ile Leu Val 
            500                 505                 510         


Ser Ile Val Thr Glu Phe Val Ser Asn Pro Ala Thr Ile Thr Ile Phe 
        515                 520                 525             


Leu Pro Ile Leu Cys Ser Leu Ser Glu Thr Leu His Ile Asn Pro Leu 
    530                 535                 540                 


Tyr Thr Leu Ile Pro Val Thr Met Cys Ile Ser Phe Ala Val Met Leu 
545                 550                 555                 560 


Pro Val Gly Asn Pro Pro Asn Ala Ile Val Phe Ser Tyr Gly His Cys 
                565                 570                 575     


Gln Ile Lys Asp Met Val Lys Ala Gly Leu Gly Val Asn Val Ile Gly 
            580                 585                 590         


Leu Val Ile Val Met Val Ala Ile Asn Thr Trp Gly Val Ser Leu Phe 
        595                 600                 605             


His Leu Asp Thr Tyr Pro Ala Trp Ala Arg Val Ser Asn Ile Thr Asp 
    610                 615                 620                 


Gln Ala 
625     


<210>  3779
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  3779

Met His Ile Pro Lys Ser Leu Gln Glu Leu Ala Asn Ser Glu Ala Val 
1               5                   10                  15      


Gln Phe Leu Arg Arg Pro Lys Thr Ile Thr Arg Val Phe Glu Gly Val 
            20                  25                  30          


Phe Ser Leu Ile Val Phe Ser Ser Leu Leu Thr Asp Gly Tyr Gln Asn 
        35                  40                  45              


Lys Met Glu Ser Pro Gln Leu His Cys Ile Leu Asn Ser Asn Ser Val 
    50                  55                  60                  


Ala Cys Ser Phe Ala Val Gly Ala Gly Phe Leu Ala Phe Leu Ser Cys 
65                  70                  75                  80  


Leu Ala Phe Leu Val Leu Asp Thr Gln Glu Thr Arg Ile Ala Gly Thr 
                85                  90                  95      


Arg Phe Lys Thr Ala Phe Gln Leu Leu Asp Phe Ile Leu Ala Val Leu 
            100                 105                 110         


Trp Ala Val Val Trp Phe Met Gly Phe Cys Phe Leu Ala Asn Gln Trp 
        115                 120                 125             


Gln His Ser Pro Pro Lys Glu Phe Leu Leu Gly Ser Ser Ser Ala Gln 
    130                 135                 140                 


Ala Ala Ile Ala Phe Thr Phe Phe Ser Ile Leu Val Trp Ile Phe Gln 
145                 150                 155                 160 


Ala Tyr Leu Ala Phe Gln Asp Leu Arg Asn Asp Ala Pro Val Pro Tyr 
                165                 170                 175     


Lys Arg Phe Leu Asp Glu Gly Gly Met Val Leu Thr Thr Leu Pro Leu 
            180                 185                 190         


Pro Ser Ala Asn Ser Pro Val Asn Met Pro Thr Thr Gly Pro Asn Ser 
        195                 200                 205             


Leu Ser Tyr Ala Ser Ser Ala Leu Ser Pro Cys Leu Thr Ala Pro Lys 
    210                 215                 220                 


Ser Pro Arg Leu Ala Met Met Pro Asp Asn 
225                 230                 


<210>  3780
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  3780

Met Ser Gly Leu Gly Arg Ser Arg Arg Gly Gly Arg Ser Arg Val Asp 
1               5                   10                  15      


Gln Glu Glu Arg Phe Pro Gln Gly Leu Trp Thr Gly Val Ala Met Arg 
            20                  25                  30          


Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu Gly Thr Cys Met 
        35                  40                  45              


Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg Thr Cys Ala Ala 
    50                  55                  60                  


Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp 
65                  70                  75                  80  


His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His 
                85                  90                  95      


Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Pro Val 
            100                 105                 110         


Asn Leu Pro Pro Glu Leu Arg Arg Gln Arg Ser Gly Glu Val Glu Asn 
        115                 120                 125             


Asn Ser Asp Asn Ser Gly Arg Tyr Gln Gly Leu Glu His Arg Gly Ser 
    130                 135                 140                 


Glu Ala Ser Pro Ala Leu Pro Gly Leu Lys Leu Ser Ala Asp Gln Val 
145                 150                 155                 160 


Ala Leu Val Tyr Ser Thr Leu Gly Leu Cys Leu Cys Ala Val Leu Cys 
                165                 170                 175     


Cys Phe Leu Val Ala Val Ala Cys Phe Leu Lys Lys Arg Gly Asp Pro 
            180                 185                 190         


Cys Ser Cys Gln Pro Arg Ser Arg Pro Arg Gln Ser Pro Ala Lys Ser 
        195                 200                 205             


Ser Gln Asp His Ala Met Glu Ala Gly Ser Pro Val Ser Thr Ser Pro 
    210                 215                 220                 


Glu Pro Val Glu Thr Cys Ser Phe Cys Phe Pro Glu Cys Arg Ala Pro 
225                 230                 235                 240 


Thr Gln Glu Ser Ala Val Thr Pro Gly Thr Pro Asp Pro Thr Cys Ala 
                245                 250                 255     


Gly Arg Trp Gly Cys His Thr Arg Thr Thr Val Leu Gln Pro Cys Pro 
            260                 265                 270         


His Ile Pro Asp Ser Gly Leu Gly Ile Val Cys Val Pro Ala Gln Glu 
        275                 280                 285             


Gly Gly Pro Gly Ala 
    290             


<210>  3781
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  3781

Met Glu Leu Ser Gln Met Ser Glu Leu Met Gly Leu Ser Val Leu Leu 
1               5                   10                  15      


Gly Leu Leu Ala Leu Met Ala Thr Ala Ala Val Ala Arg Gly Trp Leu 
            20                  25                  30          


Arg Ala Gly Glu Glu Arg Ser Gly Arg Pro Ala Cys Gln Lys Ala Asn 
        35                  40                  45              


Gly Phe Pro Pro Asp Lys Ser Ser Gly Ser Lys Lys Gln Lys Gln Tyr 
    50                  55                  60                  


Gln Arg Ile Arg Lys Glu Lys Pro Gln Gln His Asn Phe Thr His Arg 
65                  70                  75                  80  


Leu Leu Ala Ala Ala Leu Lys Ser His Ser Gly Asn Ile Ser Cys Met 
                85                  90                  95      


Asp Phe Ser Ser Asn Gly Lys Tyr Leu Ala Thr Cys Ala Asp Asp Arg 
            100                 105                 110         


Thr Ile Arg Ile Trp Ser Thr Lys Asp Phe Leu Gln Arg Glu His Arg 
        115                 120                 125             


Ser Met Arg Ala Asn Val Glu Leu Asp His Ala Thr Leu Val Arg Phe 
    130                 135                 140                 


Ser Pro Asp Cys Arg Ala Phe Ile Val Trp Leu Ala Asn Gly Asp Thr 
145                 150                 155                 160 


Leu Arg Val Phe Lys Met Thr Lys Arg Glu Asp Gly Gly Tyr Thr Phe 
                165                 170                 175     


Thr Ala Thr Pro Glu Asp Phe Pro Lys Lys His Lys Ala Pro Val Ile 
            180                 185                 190         


Asp Ile Gly Ile Ala Asn Thr Gly Lys Phe Ile Met Thr Ala Ser Ser 
        195                 200                 205             


Asp Thr Thr Val Leu Ile Trp Ser Leu Lys Gly Gln Val Leu Ser Thr 
    210                 215                 220                 


Ile Asn Thr Asn Gln Met Asn Asn Thr His Ala Ala Val Ser Pro Cys 
225                 230                 235                 240 


Gly Arg Phe Val Ala Ser Cys Gly Phe Thr Pro Asp Val Lys Val Trp 
                245                 250                 255     


Glu Val Cys Phe Gly Lys Lys Gly Glu Phe Gln Glu Val Val Arg Ala 
            260                 265                 270         


Phe Glu Leu Lys Gly His Ser Ala Ala Val His Ser Phe Ala Phe Ser 
        275                 280                 285             


Asn Asp Ser Arg Arg Met Ala Ser Val Ser Lys Asp Gly Thr Trp Lys 
    290                 295                 300                 


Leu Trp Asp Thr Asp Val Glu Tyr Lys Lys Lys Gln Asp Pro Tyr Leu 
305                 310                 315                 320 


Leu Lys Thr Gly Arg Phe Glu Glu Ala Ala Gly Ala Ala Pro Cys Arg 
                325                 330                 335     


Leu Ala Leu Ser Pro Asn Ala Gln Val Leu Ala Leu Ala Ser Gly Ser 
            340                 345                 350         


Ser Ile His Leu Tyr Asn Thr Arg Arg Gly Glu Lys Glu Glu Cys Phe 
        355                 360                 365             


Glu Arg Val His Gly Glu Cys Ile Ala Asn Leu Ser Phe Asp Ile Thr 
    370                 375                 380                 


Gly Arg Phe Leu Ala Ser Cys Gly Asp Arg Ala Val Arg Leu Phe His 
385                 390                 395                 400 


Asn Thr Pro Gly His Arg Ala Met Val Glu Glu Met Gln Gly His Leu 
                405                 410                 415     


Lys Arg Ala Ser Asn Glu Ser Thr Arg Gln Arg Leu Gln Gln Gln Leu 
            420                 425                 430         


Thr Gln Ala Gln Glu Thr Leu Lys Ser Leu Gly Ala Leu Lys Lys 
        435                 440                 445         


<210>  3782
<211>  856
<212>  PRT
<213>  Homo sapiens

<400>  3782

Met Gly Ser Leu Phe Arg Ser Glu Thr Met Cys Leu Ala Gln Leu Phe 
1               5                   10                  15      


Leu Gln Ser Gly Thr Ala Tyr Glu Cys Leu Ser Ala Leu Gly Glu Lys 
            20                  25                  30          


Gly Leu Val Gln Phe Arg Asp Leu Asn Gln Asn Val Ser Ser Phe Gln 
        35                  40                  45              


Arg Lys Phe Val Gly Glu Val Lys Arg Cys Glu Glu Leu Glu Arg Ile 
    50                  55                  60                  


Leu Val Tyr Leu Val Gln Glu Ile Asn Arg Ala Asp Ile Pro Leu Pro 
65                  70                  75                  80  


Glu Gly Glu Ala Ser Pro Pro Ala Pro Pro Leu Lys Gln Val Leu Glu 
                85                  90                  95      


Met Gln Glu Gln Leu Gln Lys Leu Glu Val Glu Leu Arg Glu Val Thr 
            100                 105                 110         


Lys Asn Lys Glu Lys Leu Arg Lys Asn Leu Leu Glu Leu Ile Glu Tyr 
        115                 120                 125             


Thr His Met Leu Arg Val Thr Lys Thr Phe Val Lys Arg Asn Val Glu 
    130                 135                 140                 


Phe Glu Pro Thr Tyr Glu Glu Phe Pro Ser Leu Glu Ser Asp Ser Leu 
145                 150                 155                 160 


Leu Asp Tyr Ser Cys Met Gln Arg Leu Gly Ala Lys Leu Gly Phe Val 
                165                 170                 175     


Ser Gly Leu Ile Asn Gln Gly Lys Val Glu Ala Phe Glu Lys Met Leu 
            180                 185                 190         


Trp Arg Val Cys Lys Gly Tyr Thr Ile Val Ser Tyr Ala Glu Leu Asp 
        195                 200                 205             


Glu Ser Leu Glu Asp Pro Glu Thr Gly Glu Val Ile Lys Trp Tyr Val 
    210                 215                 220                 


Phe Leu Ile Ser Phe Trp Gly Glu Gln Ile Gly His Lys Val Lys Lys 
225                 230                 235                 240 


Ile Cys Asp Cys Tyr His Cys His Val Tyr Pro Tyr Pro Asn Thr Ala 
                245                 250                 255     


Glu Glu Arg Arg Glu Ile Gln Glu Gly Leu Asn Thr Arg Ile Gln Asp 
            260                 265                 270         


Leu Tyr Thr Val Leu His Lys Thr Glu Asp Tyr Leu Arg Gln Val Leu 
        275                 280                 285             


Cys Lys Ala Ala Glu Ser Val Tyr Ser Arg Val Ile Gln Val Lys Lys 
    290                 295                 300                 


Met Lys Ala Ile Tyr His Met Leu Asn Met Cys Ser Phe Asp Val Thr 
305                 310                 315                 320 


Asn Lys Cys Leu Ile Ala Glu Val Trp Cys Pro Glu Ala Asp Leu Gln 
                325                 330                 335     


Asp Leu Arg Arg Ala Leu Glu Glu Gly Ser Arg Glu Ser Gly Ala Thr 
            340                 345                 350         


Ile Pro Ser Phe Met Asn Ile Ile Pro Thr Lys Glu Thr Pro Pro Thr 
        355                 360                 365             


Arg Ile Arg Thr Asn Lys Phe Thr Glu Gly Phe Gln Asn Ile Val Asp 
    370                 375                 380                 


Ala Tyr Gly Val Gly Ser Tyr Arg Glu Val Asn Pro Ala Leu Phe Thr 
385                 390                 395                 400 


Ile Ile Thr Phe Pro Phe Leu Phe Ala Val Met Phe Gly Asp Phe Gly 
                405                 410                 415     


His Gly Phe Val Met Phe Leu Phe Ala Leu Leu Leu Val Leu Asn Glu 
            420                 425                 430         


Asn His Pro Arg Leu Asn Gln Ser Gln Glu Ile Met Arg Met Phe Phe 
        435                 440                 445             


Asn Gly Arg Tyr Ile Leu Leu Leu Met Gly Leu Phe Ser Val Tyr Thr 
    450                 455                 460                 


Gly Leu Ile Tyr Asn Asp Cys Phe Ser Lys Ser Val Asn Leu Phe Gly 
465                 470                 475                 480 


Ser Gly Trp Asn Val Ser Ala Met Tyr Ser Ser Ser His Pro Pro Ala 
                485                 490                 495     


Glu His Lys Lys Met Val Leu Trp Asn Asp Ser Val Val Arg His Asn 
            500                 505                 510         


Ser Ile Leu Gln Leu Asp Pro Ser Ile Pro Gly Val Phe Arg Gly Pro 
        515                 520                 525             


Tyr Pro Leu Gly Ile Asp Pro Ile Trp Asn Leu Ala Thr Asn Arg Leu 
    530                 535                 540                 


Thr Phe Leu Asn Ser Phe Lys Met Lys Met Ser Val Ile Leu Gly Ile 
545                 550                 555                 560 


Ile His Met Thr Phe Gly Val Ile Leu Gly Ile Phe Asn His Leu His 
                565                 570                 575     


Phe Arg Lys Lys Phe Asn Ile Tyr Leu Val Ser Ile Pro Glu Leu Leu 
            580                 585                 590         


Phe Met Leu Cys Ile Phe Gly Tyr Leu Ile Phe Met Ile Phe Tyr Lys 
        595                 600                 605             


Trp Leu Val Phe Ser Ala Glu Thr Ser Arg Val Ala Pro Ser Ile Leu 
    610                 615                 620                 


Ile Glu Phe Ile Asn Met Phe Leu Phe Pro Ala Ser Lys Thr Ser Gly 
625                 630                 635                 640 


Leu Tyr Thr Gly Gln Glu Tyr Val Gln Arg Val Leu Leu Val Val Thr 
                645                 650                 655     


Ala Leu Ser Val Pro Val Leu Phe Leu Gly Lys Pro Leu Phe Leu Leu 
            660                 665                 670         


Trp Leu His Asn Gly Arg Ser Cys Phe Gly Val Asn Arg Ser Gly Tyr 
        675                 680                 685             


Thr Leu Ile Arg Lys Asp Ser Glu Glu Glu Val Ser Leu Leu Gly Ser 
    690                 695                 700                 


Gln Asp Ile Glu Glu Gly Asn His Gln Val Glu Asp Gly Cys Arg Glu 
705                 710                 715                 720 


Met Ala Cys Glu Glu Phe Asn Phe Gly Glu Ile Leu Met Thr Gln Val 
                725                 730                 735     


Ile His Ser Ile Glu Tyr Cys Leu Gly Cys Ile Ser Asn Thr Ala Ser 
            740                 745                 750         


Tyr Leu Arg Leu Trp Ala Leu Ser Leu Ala His Ala Gln Leu Ser Asp 
        755                 760                 765             


Val Leu Trp Ala Met Leu Met Arg Val Gly Leu Arg Val Asp Thr Thr 
    770                 775                 780                 


Tyr Gly Val Leu Leu Leu Leu Pro Val Ile Ala Leu Phe Ala Val Leu 
785                 790                 795                 800 


Thr Ile Phe Ile Leu Leu Ile Met Glu Gly Leu Ser Ala Phe Leu His 
                805                 810                 815     


Ala Ile Arg Leu His Trp Val Glu Phe Gln Asn Lys Phe Tyr Val Gly 
            820                 825                 830         


Ala Gly Thr Lys Phe Val Pro Phe Ser Phe Ser Leu Leu Ser Ser Lys 
        835                 840                 845             


Phe Asn Asn Asp Asp Ser Val Ala 
    850                 855     


<210>  3783
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  3783

Met Ala Glu Ile His Thr Pro Tyr Ser Ser Leu Lys Lys Leu Leu Ser 
1               5                   10                  15      


Leu Leu Asn Gly Phe Val Ala Val Ser Gly Ile Ile Leu Val Gly Leu 
            20                  25                  30          


Gly Ile Gly Gly Lys Cys Gly Gly Ala Ser Leu Thr Asn Val Leu Gly 
        35                  40                  45              


Leu Ser Ser Ala Tyr Leu Leu His Val Gly Asn Leu Cys Leu Val Met 
    50                  55                  60                  


Gly Cys Ile Thr Val Leu Leu Gly Cys Ala Gly Trp Tyr Gly Ala Thr 
65                  70                  75                  80  


Lys Glu Ser Arg Gly Thr Leu Leu Phe Cys Ile Leu Ser Met Val Ile 
                85                  90                  95      


Val Leu Ile Met Glu Val Thr Ala Ala Thr Val Val Leu Leu Phe Phe 
            100                 105                 110         


Pro Ile Val Gly Asp Val Ala Leu Glu His Thr Phe Val Thr Leu Arg 
        115                 120                 125             


Lys Asn Tyr Arg Gly Tyr Asn Glu Pro Asp Asp Tyr Ser Thr Gln Trp 
    130                 135                 140                 


Asn Leu Val Met Glu Lys Leu Lys Cys Cys Gly Val Asn Asn Tyr Thr 
145                 150                 155                 160 


Asp Phe Ser Gly Ser Ser Phe Glu Met Thr Thr Gly His Thr Tyr Pro 
                165                 170                 175     


Arg Ser Cys Cys Lys Ser Ile Gly Ser Val Ser Cys Asp Gly Arg Asp 
            180                 185                 190         


Val Ser Pro Asn Val Ile His Gln Lys Gly Cys Phe His Lys Leu Leu 
        195                 200                 205             


Lys Ile Thr Lys Thr Gln Ser Phe Thr Leu Ser Gly Ser Ser Leu Gly 
    210                 215                 220                 


Ala Ala Val Ile Gln Arg Trp Gly Ser Arg Tyr Val Ala Gln Ala Gly 
225                 230                 235                 240 


Leu Glu Leu Leu Ala 
                245 


<210>  3784
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  3784

Met Ala Leu Gly Ala Cys Gly Leu Leu Leu Leu Leu Ala Val Pro Gly 
1               5                   10                  15      


Val Ser Leu Arg Thr Leu Gln Pro Gly Cys Gly Arg Pro Gln Val Ser 
            20                  25                  30          


Asp Ala Gly Gly Arg Ile Val Gly Gly His Ala Ala Pro Ala Gly Ala 
        35                  40                  45              


Trp Pro Trp Gln Ala Ser Leu Arg Leu Arg Arg Val His Val Cys Gly 
    50                  55                  60                  


Gly Ser Leu Leu Ser Pro Gln Trp Val Leu Thr Ala Ala His Cys Phe 
65                  70                  75                  80  


Ser Gly Ser Leu Asn Ser Ser Asp Tyr Gln Val His Leu Gly Glu Leu 
                85                  90                  95      


Glu Ile Thr Leu Ser Pro His Phe Ser Thr Val Arg Gln Ile Ile Leu 
            100                 105                 110         


His Ser Ser Pro Ser Gly Gln Pro Gly Thr Ser Gly Asp Ile Ala Leu 
        115                 120                 125             


Val Glu Leu Ser Val Pro Val Thr Leu Ser Ser Arg Ile Leu Pro Val 
    130                 135                 140                 


Cys Leu Pro Glu Ala Ser Asp Asp Phe Cys Pro Gly Ile Arg Cys Trp 
145                 150                 155                 160 


Val Thr Gly Trp Gly Tyr Thr Arg Glu Gly Glu Pro Leu Pro Pro Pro 
                165                 170                 175     


Tyr Ser Leu Arg Glu Val Lys Val Ser Val Val Asp Thr Glu Thr Cys 
            180                 185                 190         


Arg Arg Asp Tyr Pro Gly Pro Gly Gly Ser Ile Leu Gln Pro Asp Met 
        195                 200                 205             


Leu Cys Ala Arg Gly Pro Gly Asp Ala Cys Gln Asp Asp Ser Gly Gly 
    210                 215                 220                 


Pro Leu Val Cys Gln Val Asn Gly Ala Trp Val Gln Ala Gly Ile Val 
225                 230                 235                 240 


Ser Trp Gly Glu Gly Cys Gly Arg Pro Asn Arg Pro Gly Val Tyr Thr 
                245                 250                 255     


Arg Val Pro Ala Tyr Val Asn Trp Ile Arg Arg His Ile Thr Ala Ser 
            260                 265                 270         


Gly Gly Ser Glu Ser Gly Tyr Pro Arg Leu Pro Leu Leu Ala Gly Phe 
        275                 280                 285             


Phe Leu Pro Gly Leu Phe Leu Leu Leu Val Ser Cys Val Leu Leu Ala 
    290                 295                 300                 


Lys Cys Leu Leu His Pro Ser Ala Asp Gly Thr Pro Phe Pro Ala Pro 
305                 310                 315                 320 


Asp 
    


<210>  3785
<211>  973
<212>  PRT
<213>  Homo sapiens

<400>  3785

Met Ala Gln Leu Tyr Tyr Lys Lys Val Asn Tyr Ser Pro Tyr Arg Asp 
1               5                   10                  15      


Arg Ile Pro Leu Gln Ile Val Arg Ala Glu Thr Glu Leu Ser Ala Glu 
            20                  25                  30          


Glu Lys Ala Phe Leu Asn Ala Val Glu Lys Gly Asp Tyr Ala Thr Val 
        35                  40                  45              


Lys Gln Ala Leu Gln Glu Ala Glu Ile Tyr Tyr Asn Val Asn Ile Asn 
    50                  55                  60                  


Cys Met Asp Pro Leu Gly Arg Ser Ala Leu Leu Ile Ala Ile Glu Asn 
65                  70                  75                  80  


Glu Asn Leu Glu Ile Met Glu Leu Leu Leu Asn His Ser Val Tyr Val 
                85                  90                  95      


Gly Asp Ala Leu Leu Tyr Ala Ile Arg Lys Glu Val Val Gly Ala Val 
            100                 105                 110         


Glu Leu Leu Leu Ser Tyr Arg Arg Pro Ser Gly Glu Lys Gln Val Pro 
        115                 120                 125             


Thr Leu Met Met Asp Thr Gln Phe Ser Glu Phe Thr Pro Asp Ile Thr 
    130                 135                 140                 


Pro Ile Met Leu Ala Ala His Thr Asn Asn Tyr Glu Ile Ile Lys Leu 
145                 150                 155                 160 


Leu Val Gln Lys Arg Val Thr Ile Pro Arg Pro His Gln Ile Arg Cys 
                165                 170                 175     


Asn Cys Val Glu Cys Val Ser Ser Ser Glu Val Asp Ser Leu Arg His 
            180                 185                 190         


Ser Arg Ser Arg Leu Asn Ile Tyr Lys Ala Leu Ala Ser Pro Ser Leu 
        195                 200                 205             


Ile Ala Leu Ser Ser Glu Asp Pro Ile Leu Thr Ala Phe Arg Leu Gly 
    210                 215                 220                 


Trp Glu Leu Lys Glu Leu Ser Lys Val Glu Asn Glu Phe Lys Ala Glu 
225                 230                 235                 240 


Tyr Glu Glu Leu Ser Gln Gln Cys Lys Leu Phe Ala Lys Asp Leu Leu 
                245                 250                 255     


Asp Gln Ala Arg Ser Ser Arg Glu Leu Glu Ile Ile Leu Asn His Arg 
            260                 265                 270         


Asp Asp His Ser Glu Glu Leu Asp Pro Gln Lys Tyr His Asp Leu Ala 
        275                 280                 285             


Lys Leu Lys Val Ala Ile Lys Tyr His Gln Lys Glu Phe Val Ala Gln 
    290                 295                 300                 


Pro Asn Cys Gln Gln Leu Leu Ala Thr Leu Trp Tyr Asp Gly Phe Pro 
305                 310                 315                 320 


Gly Trp Arg Arg Lys His Trp Val Val Lys Leu Leu Thr Cys Met Thr 
                325                 330                 335     


Ile Gly Phe Leu Phe Pro Met Leu Ser Ile Ala Tyr Leu Ile Ser Pro 
            340                 345                 350         


Arg Ser Asn Leu Gly Leu Phe Ile Lys Lys Pro Phe Ile Lys Phe Ile 
        355                 360                 365             


Cys His Thr Ala Ser Tyr Leu Thr Phe Leu Phe Met Leu Leu Leu Ala 
    370                 375                 380                 


Ser Gln His Ile Val Arg Thr Asp Leu His Val Gln Gly Pro Pro Pro 
385                 390                 395                 400 


Thr Val Val Glu Trp Met Ile Leu Pro Trp Val Leu Gly Phe Ile Trp 
                405                 410                 415     


Gly Glu Ile Lys Glu Met Trp Asp Gly Gly Phe Thr Glu Tyr Ile His 
            420                 425                 430         


Asp Trp Trp Asn Leu Met Asp Phe Ala Met Asn Ser Leu Tyr Leu Ala 
        435                 440                 445             


Thr Ile Ser Leu Lys Ile Val Ala Tyr Val Lys Tyr Asn Gly Ser Arg 
    450                 455                 460                 


Pro Arg Glu Glu Trp Glu Met Trp His Pro Thr Leu Ile Ala Glu Ala 
465                 470                 475                 480 


Leu Phe Ala Ile Ser Asn Ile Leu Ser Ser Leu Arg Leu Ile Ser Leu 
                485                 490                 495     


Phe Thr Ala Asn Ser His Leu Gly Pro Leu Gln Ile Ser Leu Gly Arg 
            500                 505                 510         


Met Leu Leu Asp Ile Leu Lys Phe Leu Phe Ile Tyr Cys Leu Val Leu 
        515                 520                 525             


Leu Ala Phe Ala Asn Gly Leu Asn Gln Leu Tyr Phe Tyr Tyr Glu Thr 
    530                 535                 540                 


Arg Ala Ile Asp Glu Pro Asn Asn Cys Lys Gly Ile Arg Cys Glu Lys 
545                 550                 555                 560 


Gln Asn Asn Ala Phe Ser Thr Leu Phe Glu Thr Leu Gln Ser Leu Phe 
                565                 570                 575     


Trp Ser Val Phe Gly Leu Leu Asn Leu Tyr Val Thr Asn Val Lys Ala 
            580                 585                 590         


Arg His Glu Phe Thr Glu Phe Val Gly Ala Thr Met Phe Gly Thr Tyr 
        595                 600                 605             


Asn Val Ile Ser Leu Val Val Leu Leu Asn Met Leu Ile Ala Met Met 
    610                 615                 620                 


Asn Asn Ser Tyr Gln Leu Ile Ala Asp His Ala Asp Ile Glu Trp Lys 
625                 630                 635                 640 


Phe Ala Arg Thr Lys Leu Trp Met Ser Tyr Phe Asp Glu Gly Gly Thr 
                645                 650                 655     


Leu Pro Pro Pro Phe Asn Ile Ile Pro Ser Pro Lys Ser Phe Leu Tyr 
            660                 665                 670         


Leu Gly Asn Trp Phe Asn Asn Thr Phe Cys Pro Lys Arg Asp Pro Asp 
        675                 680                 685             


Gly Arg Arg Arg Arg Arg Asn Leu Arg Ser Phe Thr Glu Arg Asn Ala 
    690                 695                 700                 


Asp Ser Leu Ile Gln Asn Gln His Tyr Gln Glu Val Ile Arg Asn Leu 
705                 710                 715                 720 


Val Lys Arg Tyr Val Ala Ala Met Ile Arg Asn Ser Lys Thr His Glu 
                725                 730                 735     


Gly Leu Thr Glu Glu Asn Phe Lys Glu Leu Lys Gln Asp Ile Ser Ser 
            740                 745                 750         


Phe Arg Tyr Glu Val Leu Asp Leu Leu Gly Asn Arg Lys His Pro Arg 
        755                 760                 765             


Ser Phe Ser Thr Ser Ser Thr Glu Leu Ser Gln Arg Asp Asp Asn Asn 
    770                 775                 780                 


Asp Gly Ser Gly Gly Ala Arg Ala Lys Ser Lys Ser Val Ser Phe Asn 
785                 790                 795                 800 


Leu Gly Cys Lys Lys Lys Thr Cys His Gly Pro Pro Leu Ile Arg Thr 
                805                 810                 815     


Met Pro Arg Ser Ser Gly Ala Gln Gly Lys Ser Lys Ala Glu Ser Ser 
            820                 825                 830         


Ser Lys Arg Ser Phe Met Gly Pro Ser Leu Lys Lys Leu Gly Leu Leu 
        835                 840                 845             


Phe Ser Lys Phe Asn Gly His Met Ser Glu Pro Ser Ser Glu Pro Met 
    850                 855                 860                 


Tyr Thr Ile Ser Asp Gly Ile Val Gln Gln His Cys Met Trp Gln Asp 
865                 870                 875                 880 


Ile Arg Tyr Ser Gln Met Glu Lys Gly Lys Ala Glu Ala Cys Ser Gln 
                885                 890                 895     


Ser Glu Ile Asn Leu Ser Glu Val Glu Leu Gly Glu Val Gln Gly Ala 
            900                 905                 910         


Ala Gln Ser Ser Glu Cys Pro Leu Ala Cys Ser Ser Ser Leu His Cys 
        915                 920                 925             


Ala Ser Ser Ile Cys Ser Ser Asn Ser Lys Leu Leu Asp Ser Ser Glu 
    930                 935                 940                 


Asp Val Phe Glu Thr Trp Gly Glu Ala Cys Asp Leu Leu Met His Lys 
945                 950                 955                 960 


Trp Gly Asp Gly Gln Glu Glu Gln Val Thr Thr Arg Leu 
                965                 970             


<210>  3786
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  3786

Met Leu Thr Phe Met Ala Ser Asp Ser Glu Glu Glu Val Cys Asp Glu 
1               5                   10                  15      


Arg Thr Ser Leu Met Ser Ala Glu Ser Pro Thr Pro Arg Ser Cys Gln 
            20                  25                  30          


Glu Gly Arg Gln Gly Pro Glu Asp Gly Glu Asn Thr Ala Gln Trp Arg 
        35                  40                  45              


Ser Gln Glu Asn Glu Glu Asp Gly Glu Glu Asp Pro Asp Arg Tyr Val 
    50                  55                  60                  


Cys Ser Gly Val Pro Gly Arg Pro Pro Gly Leu Glu Glu Glu Leu Thr 
65                  70                  75                  80  


Leu Lys Tyr Gly Ala Lys His Val Ile Met Leu Phe Val Pro Val Thr 
                85                  90                  95      


Leu Cys Met Ile Val Val Val Ala Thr Ile Lys Ser Val Arg Phe Tyr 
            100                 105                 110         


Thr Glu Lys Asn Gly Gln Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr 
        115                 120                 125             


Pro Ser Val Gly Gln Arg Leu Leu Asn Ser Val Leu Asn Thr Leu Ile 
    130                 135                 140                 


Met Ile Ser Val Ile Val Val Met Thr Ile Phe Leu Val Val Leu Tyr 
145                 150                 155                 160 


Lys Tyr Arg Cys Tyr Lys Phe Ile His Gly Trp Leu Ile Met Ser Ser 
                165                 170                 175     


Leu Met Leu Leu Phe Leu Phe Thr Tyr Ile Tyr Leu Gly Glu Val Leu 
            180                 185                 190         


Lys Thr Tyr Asn Val Ala Met Asp Tyr Pro Thr Leu Leu Leu Thr Val 
        195                 200                 205             


Trp Asn Phe Gly Ala Val Gly Met Val Cys Ile His Trp Lys Gly Pro 
    210                 215                 220                 


Leu Val Leu Gln Gln Ala Tyr Leu Ile Met Ile Ser Ala Leu Met Ala 
225                 230                 235                 240 


Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp Ser Ala Trp Val Ile Leu 
                245                 250                 255     


Gly Ala Ile Ser Val Tyr Asp Leu Val Ala Val Leu Cys Pro Lys Gly 
            260                 265                 270         


Pro Leu Arg Met Leu Val Glu Thr Ala Gln Glu Arg Asn Glu Pro Ile 
        275                 280                 285             


Phe Pro Ala Leu Ile Tyr Ser Ser Ala Met Val Trp Thr Val Gly Met 
    290                 295                 300                 


Ala Lys Leu Asp Pro Ser Ser Gln Gly Ala Leu Gln Leu Pro Tyr Asp 
305                 310                 315                 320 


Pro Glu Met Glu Asp Ser Tyr Asp Ser Phe Gly Glu Pro Ser Tyr Pro 
                325                 330                 335     


Glu Val Phe Glu Pro Pro Leu Thr Gly Tyr Pro Gly Glu Glu Leu Glu 
            340                 345                 350         


Glu Glu Glu Glu Arg Gly Val Lys Leu Gly Leu Gly Asp Phe Ile Phe 
        355                 360                 365             


Tyr Ser Val Leu Val Gly Lys Ala Ala Ala Thr Gly Ser Gly Asp Trp 
    370                 375                 380                 


Asn Thr Thr Leu Ala Cys Phe Val Ala Ile Leu Ile Gly Leu Cys Leu 
385                 390                 395                 400 


Thr Leu Leu Leu Leu Ala Val Phe Lys Lys Ala Leu Pro Ala Leu Pro 
                405                 410                 415     


Ile Ser Ile Thr Phe Gly Leu Ile Phe Tyr Phe Ser Thr Asp Asn Leu 
            420                 425                 430         


Val Arg Pro Phe Met Asp Thr Leu Ala Ser His Gln Leu Tyr Ile 
        435                 440                 445         


<210>  3787
<211>  660
<212>  PRT
<213>  Homo sapiens

<400>  3787

Met Gly Leu Gln Thr Thr Lys Trp Pro Ser His Gly Ala Phe Phe Leu 
1               5                   10                  15      


Lys Ser Trp Leu Ile Ile Ser Leu Gly Leu Tyr Ser Gln Val Ser Lys 
            20                  25                  30          


Leu Leu Ala Cys Pro Ser Val Cys Arg Cys Asp Arg Asn Phe Val Tyr 
        35                  40                  45              


Cys Asn Glu Arg Ser Leu Thr Ser Val Pro Leu Gly Ile Pro Glu Gly 
    50                  55                  60                  


Val Thr Val Leu Tyr Leu His Asn Asn Gln Ile Asn Asn Ala Gly Phe 
65                  70                  75                  80  


Pro Ala Glu Leu His Asn Val Gln Ser Val His Thr Val Tyr Leu Tyr 
                85                  90                  95      


Gly Asn Gln Leu Asp Glu Phe Pro Met Asn Leu Pro Lys Asn Val Arg 
            100                 105                 110         


Val Leu His Leu Gln Glu Asn Asn Ile Gln Thr Ile Ser Arg Ala Ala 
        115                 120                 125             


Leu Ala Gln Leu Leu Lys Leu Glu Glu Leu His Leu Asp Asp Asn Ser 
    130                 135                 140                 


Ile Ser Thr Val Gly Val Glu Asp Gly Ala Phe Arg Glu Ala Ile Ser 
145                 150                 155                 160 


Leu Lys Leu Leu Phe Leu Ser Lys Asn His Leu Ser Ser Val Pro Val 
                165                 170                 175     


Gly Leu Pro Val Asp Leu Gln Glu Leu Arg Val Asp Glu Asn Arg Ile 
            180                 185                 190         


Ala Val Ile Ser Asp Met Ala Phe Gln Asn Leu Thr Ser Leu Glu Arg 
        195                 200                 205             


Leu Ile Val Asp Gly Asn Leu Leu Thr Asn Lys Gly Ile Ala Glu Gly 
    210                 215                 220                 


Thr Phe Ser His Leu Thr Lys Leu Lys Glu Phe Ser Ile Val Arg Asn 
225                 230                 235                 240 


Ser Leu Ser His Pro Pro Pro Asp Leu Pro Gly Thr His Leu Ile Arg 
                245                 250                 255     


Leu Tyr Leu Gln Asp Asn Gln Ile Asn His Ile Pro Leu Thr Ala Phe 
            260                 265                 270         


Ser Asn Leu Arg Lys Leu Glu Arg Leu Asp Ile Ser Asn Asn Gln Leu 
        275                 280                 285             


Arg Met Leu Thr Gln Gly Val Phe Asp Asn Leu Ser Asn Leu Lys Gln 
    290                 295                 300                 


Leu Thr Ala Arg Asn Asn Pro Trp Phe Cys Asp Cys Ser Ile Lys Trp 
305                 310                 315                 320 


Val Thr Glu Trp Leu Lys Tyr Ile Pro Ser Ser Leu Asn Val Arg Gly 
                325                 330                 335     


Phe Met Cys Gln Gly Pro Glu Gln Val Arg Gly Met Ala Val Arg Glu 
            340                 345                 350         


Leu Asn Met Asn Leu Leu Ser Cys Pro Thr Thr Thr Pro Gly Leu Pro 
        355                 360                 365             


Leu Phe Thr Pro Ala Pro Ser Thr Ala Ser Pro Thr Thr Gln Pro Pro 
    370                 375                 380                 


Thr Leu Ser Ile Pro Asn Pro Ser Arg Ser Tyr Thr Pro Pro Thr Pro 
385                 390                 395                 400 


Thr Thr Ser Lys Leu Pro Thr Ile Pro Asp Trp Asp Gly Arg Glu Arg 
                405                 410                 415     


Val Thr Pro Pro Ile Ser Glu Arg Ile Gln Leu Ser Ile His Phe Val 
            420                 425                 430         


Asn Asp Thr Ser Ile Gln Val Ser Trp Leu Ser Leu Phe Thr Val Met 
        435                 440                 445             


Ala Tyr Lys Leu Thr Trp Val Lys Met Gly His Ser Leu Val Gly Gly 
    450                 455                 460                 


Ile Val Gln Glu Arg Ile Val Ser Gly Glu Lys Gln His Leu Ser Leu 
465                 470                 475                 480 


Val Asn Leu Glu Pro Arg Ser Thr Tyr Arg Ile Cys Leu Val Pro Leu 
                485                 490                 495     


Asp Ala Phe Asn Tyr Arg Ala Val Glu Asp Thr Ile Cys Ser Glu Ala 
            500                 505                 510         


Thr Thr His Ala Ser Tyr Leu Asn Asn Gly Ser Asn Thr Ala Ser Ser 
        515                 520                 525             


His Glu Gln Thr Thr Ser His Ser Met Gly Ser Pro Phe Leu Leu Ala 
    530                 535                 540                 


Gly Leu Ile Gly Gly Ala Val Ile Phe Val Leu Val Val Leu Leu Ser 
545                 550                 555                 560 


Val Phe Cys Trp His Met His Lys Lys Gly Arg Tyr Thr Ser Gln Lys 
                565                 570                 575     


Trp Lys Tyr Asn Arg Gly Arg Arg Lys Asp Asp Tyr Cys Glu Ala Gly 
            580                 585                 590         


Thr Lys Lys Asp Asn Ser Ile Leu Glu Met Thr Glu Thr Ser Phe Gln 
        595                 600                 605             


Ile Val Ser Leu Asn Asn Asp Gln Leu Leu Lys Gly Asp Phe Arg Leu 
    610                 615                 620                 


Gln Pro Ile Tyr Thr Pro Asn Gly Gly Ile Asn Tyr Thr Asp Cys His 
625                 630                 635                 640 


Ile Pro Asn Asn Met Arg Tyr Cys Asn Ser Ser Val Pro Asp Leu Glu 
                645                 650                 655     


His Cys His Thr 
            660 


<210>  3788
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  3788

Met Ala Ala Arg Gly Val Ile Ala Pro Val Gly Glu Ser Leu Arg Tyr 
1               5                   10                  15      


Ala Glu Tyr Leu Gln Pro Ser Ala Lys Arg Pro Asp Ala Asp Val Asp 
            20                  25                  30          


Gln Gln Arg Leu Val Arg Ser Leu Ile Ala Val Gly Leu Gly Val Ala 
        35                  40                  45              


Ala Leu Ala Phe Ala Gly Arg Tyr Ala Phe Arg Ile Trp Lys Pro Leu 
    50                  55                  60                  


Glu Gln Val Ile Thr Glu Thr Ala Lys Lys Ile Ser Thr Pro Ser Phe 
65                  70                  75                  80  


Ser Ser Tyr Tyr Lys Gly Gly Phe Glu Gln Lys Met Ser Arg Arg Glu 
                85                  90                  95      


Ala Gly Leu Ile Leu Gly Val Ser Pro Ser Ala Gly Lys Ala Lys Ile 
            100                 105                 110         


Arg Thr Ala His Arg Arg Val Met Ile Leu Asn His Pro Asp Lys Gly 
        115                 120                 125             


Gly Ser Pro Tyr Val Ala Ala Lys Ile Asn Glu Ala Lys Asp Leu Leu 
    130                 135                 140                 


Glu Thr Thr Thr Lys His 
145                 150 


<210>  3789
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  3789

Met Ala Ala Pro Arg Ala Gly Arg Gly Ala Gly Trp Ser Leu Arg Ala 
1               5                   10                  15      


Trp Arg Ala Leu Gly Gly Ile Arg Trp Gly Arg Arg Pro Arg Leu Thr 
            20                  25                  30          


Pro Asp Leu Arg Ala Leu Leu Thr Ser Gly Thr Ser Asp Pro Arg Ala 
        35                  40                  45              


Arg Val Thr Tyr Gly Thr Pro Ser Leu Trp Ala Arg Leu Ser Val Gly 
    50                  55                  60                  


Val Thr Glu Pro Arg Ala Cys Leu Thr Ser Gly Thr Pro Gly Pro Arg 
65                  70                  75                  80  


Ala Gln Leu Thr Ala Val Thr Pro Asp Thr Arg Thr Arg Glu Ala Ser 
                85                  90                  95      


Glu Asn Ser Gly Thr Arg Ser Arg Ala Trp Leu Ala Val Ala Leu Gly 
            100                 105                 110         


Ala Gly Gly Ala Val Leu Leu Leu Leu Trp Gly Gly Gly Arg Gly Pro 
        115                 120                 125             


Pro Ala Val Leu Ala Ala Val Pro Ser Pro Pro Pro Ala Ser Pro Arg 
    130                 135                 140                 


Ser Gln Tyr Asn Phe Ile Ala Asp Val Val Glu Lys Thr Ala Pro Ala 
145                 150                 155                 160 


Val Val Tyr Ile Glu Ile Leu Asp Arg His Pro Phe Leu Gly Arg Glu 
                165                 170                 175     


Val Pro Ile Ser Asn Gly Ser Gly Phe Val Val Ala Ala Asp Gly Leu 
            180                 185                 190         


Ile Val Thr Asn Ala His Val Val Ala Asp Arg Arg Arg Val Arg Val 
        195                 200                 205             


Arg Leu Leu Ser Gly Asp Thr Tyr Glu Ala Val Val Thr Ala Val Asp 
    210                 215                 220                 


Pro Val Ala Asp Ile Ala Thr Leu Arg Ile Gln Thr Lys Glu Pro Leu 
225                 230                 235                 240 


Pro Thr Leu Pro Leu Gly Arg Ser Ala Asp Val Arg Gln Gly Glu Phe 
                245                 250                 255     


Val Val Ala Met Gly Ser Pro Phe Ala Leu Gln Asn Thr Ile Thr Ser 
            260                 265                 270         


Gly Ile Val Ser Ser Ala Gln Arg Pro Ala Arg Asp Leu Gly Leu Pro 
        275                 280                 285             


Gln Thr Asn Val Glu Tyr Ile Gln Thr Asp Ala Ala Ile Asp Phe Gly 
    290                 295                 300                 


Asn Ser Gly Gly Pro Leu Val Asn Leu Asp Gly Glu Val Ile Gly Val 
305                 310                 315                 320 


Asn Thr Met Lys Val Thr Ala Gly Ile Ser Phe Ala Ile Pro Ser Asp 
                325                 330                 335     


Arg Leu Arg Glu Phe Leu His Arg Gly Glu Lys Lys Asn Ser Ser Ser 
            340                 345                 350         


Gly Ile Ser Gly Ser Gln Arg Arg Tyr Ile Gly Val Met Met Leu Thr 
        355                 360                 365             


Leu Ser Pro Ser Ile Leu Ala Glu Leu Gln Leu Arg Glu Pro Ser Phe 
    370                 375                 380                 


Pro Asp Val Gln His Gly Val Leu Ile His Lys Val Ile Leu Gly Ser 
385                 390                 395                 400 


Pro Ala His Arg Ala Gly Leu Arg Pro Gly Asp Val Ile Leu Ala Ile 
                405                 410                 415     


Gly Glu Gln Met Val Gln Asn Ala Glu Asp Val Tyr Glu Ala Val Arg 
            420                 425                 430         


Thr Gln Ser Gln Leu Ala Val Gln Ile Arg Arg Gly Arg Glu Thr Leu 
        435                 440                 445             


Thr Leu Tyr Val Thr Pro Glu Val Thr Glu 
    450                 455             


<210>  3790
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  3790

Met Asn Trp His Met Ile Ile Ser Gly Leu Ile Val Val Val Leu Lys 
1               5                   10                  15      


Val Val Gly Met Thr Leu Phe Leu Leu Tyr Phe Pro Gln Ile Phe Asn 
            20                  25                  30          


Lys Ser Asn Asp Gly Phe Thr Thr Thr Arg Ser Tyr Gly Thr Val Ser 
        35                  40                  45              


Gln Ile Phe Gly Ser Ser Ser Pro Ser Pro Asn Gly Phe Ile Thr Thr 
    50                  55                  60                  


Arg Ser Tyr Gly Thr Val Cys Pro Lys Asp Trp Glu Phe Tyr Gln Ala 
65                  70                  75                  80  


Arg Cys Phe Phe Leu Ser Thr Ser Glu Ser Ser Trp Asn Glu Ser Arg 
                85                  90                  95      


Asp Phe Cys Lys Gly Lys Gly Ser Thr Leu Ala Ile Val Asn Thr Pro 
            100                 105                 110         


Glu Lys Leu Lys Phe Leu Gln Asp Ile Thr Asp Ala Glu Lys Tyr Phe 
        115                 120                 125             


Ile Gly Leu Ile Tyr His Arg Glu Glu Lys Arg Trp Arg Trp Ile Asn 
    130                 135                 140                 


Asn Ser Val Phe Asn Gly Asn Val Thr Asn Gln Asn Gln Asn Phe Asn 
145                 150                 155                 160 


Cys Ala Thr Ile Gly Leu Thr Lys Thr Phe Asp Ala Ala Ser Cys Asp 
                165                 170                 175     


Ile Ser Tyr Arg Arg Ile Cys Glu Lys Asn Ala Lys 
            180                 185             


<210>  3791
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  3791

Met His Asp Ser Asn Asn Val Glu Lys Asp Ile Thr Pro Ser Glu Leu 
1               5                   10                  15      


Pro Ala Asn Pro Gly Cys Leu His Ser Lys Glu His Ser Ile Lys Ala 
            20                  25                  30          


Thr Leu Ile Trp Arg Leu Phe Phe Leu Ile Met Phe Leu Thr Ile Ile 
        35                  40                  45              


Val Cys Gly Met Val Ala Ala Leu Ser Ala Ile Arg Ala Asn Cys His 
    50                  55                  60                  


Gln Glu Pro Ser Val Cys Leu Gln Ala Ala Cys Pro Glu Ser Trp Ile 
65                  70                  75                  80  


Gly Phe Gln Arg Lys Cys Phe Tyr Phe Ser Asp Asp Thr Lys Asn Trp 
                85                  90                  95      


Thr Ser Ser Gln Arg Phe Cys Asp Ser Gln Asp Ala Asp Leu Ala Gln 
            100                 105                 110         


Val Glu Ser Phe Gln Glu Leu Asn Phe Leu Leu Arg Tyr Lys Gly Pro 
        115                 120                 125             


Ser Asp His Trp Ile Gly Leu Ser Arg Glu Gln Gly Gln Pro Trp Lys 
    130                 135                 140                 


Trp Ile Asn Gly Thr Glu Trp Thr Arg Gln Phe Pro Ile Leu Gly Ala 
145                 150                 155                 160 


Gly Glu Cys Ala Tyr Leu Asn Asp Lys Gly Ala Ser Ser Ala Arg His 
                165                 170                 175     


Tyr Thr Glu Arg Lys Trp Ile Cys Ser Lys Ser Asp Ile His Val 
            180                 185                 190     


<210>  3792
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  3792

Met Ala Gly Ser Pro Leu Leu Trp Gly Pro Arg Ala Gly Gly Val Gly 
1               5                   10                  15      


Leu Leu Val Leu Leu Leu Leu Gly Leu Phe Arg Pro Pro Pro Ala Leu 
            20                  25                  30          


Cys Ala Arg Pro Val Lys Glu Pro Arg Gly Leu Ser Ala Ala Ser Pro 
        35                  40                  45              


Pro Leu Ala Glu Thr Gly Ala Pro Arg Arg Phe Arg Arg Ser Val Pro 
    50                  55                  60                  


Arg Gly Glu Ala Ala Gly Ala Val Gln Glu Leu Ala Arg Ala Leu Ala 
65                  70                  75                  80  


His Leu Leu Glu Ala Glu Arg Gln Glu Arg Ala Arg Ala Glu Ala Gln 
                85                  90                  95      


Glu Ala Glu Asp Gln Gln Ala Arg Val Leu Ala Gln Leu Leu Arg Val 
            100                 105                 110         


Trp Gly Ala Pro Arg Asn Ser Asp Pro Ala Leu Gly Leu Asp Asp Asp 
        115                 120                 125             


Pro Asp Ala Pro Ala Ala Gln Leu Ala Arg Ala Leu Leu Arg Ala Arg 
    130                 135                 140                 


Leu Asp Pro Ala Ala Leu Ala Ala Gln Leu Val Pro Ala Pro Val Pro 
145                 150                 155                 160 


Ala Ala Ala Leu Arg Pro Arg Pro Pro Val Tyr Asp Asp Gly Pro Ala 
                165                 170                 175     


Gly Pro Asp Ala Glu Glu Ala Gly Asp Glu Thr Pro Asp Val Asp Pro 
            180                 185                 190         


Glu Leu Leu Arg Tyr Leu Leu Gly Arg Ile Leu Ala Gly Ser Ala Asp 
        195                 200                 205             


Ser Glu Gly Val Ala Ala Pro Arg Arg Leu Arg Arg Ala Ala Asp His 
    210                 215                 220                 


Asp Val Gly Ser Glu Leu Pro Pro Glu Gly Val Leu Gly Ala Leu Leu 
225                 230                 235                 240 


Arg Val Lys Arg Leu Glu Thr Pro Ala Pro Gln Val Pro Ala Arg Arg 
                245                 250                 255     


Leu Leu Pro Pro 
            260 


<210>  3793
<211>  710
<212>  PRT
<213>  Homo sapiens

<400>  3793

Met Gln Gly Lys Lys Pro Gly Gly Ser Ser Gly Gly Gly Arg Ser Gly 
1               5                   10                  15      


Glu Leu Gln Gly Asp Glu Ala Gln Arg Asn Lys Lys Lys Lys Lys Lys 
            20                  25                  30          


Val Ser Cys Phe Ser Asn Ile Lys Ile Phe Leu Val Ser Glu Cys Ala 
        35                  40                  45              


Leu Met Leu Ala Gln Gly Thr Val Gly Ala Tyr Leu Val Ser Val Leu 
    50                  55                  60                  


Thr Thr Leu Glu Arg Arg Phe Asn Leu Gln Ser Ala Asp Val Gly Val 
65                  70                  75                  80  


Ile Ala Ser Ser Phe Glu Ile Gly Asn Leu Ala Leu Ile Leu Phe Val 
                85                  90                  95      


Ser Tyr Phe Gly Ala Arg Gly His Arg Pro Arg Leu Ile Gly Cys Gly 
            100                 105                 110         


Gly Ile Val Met Ala Leu Gly Ala Leu Leu Ser Ala Leu Pro Glu Phe 
        115                 120                 125             


Leu Thr His Gln Tyr Lys Tyr Glu Ala Gly Glu Ile Arg Trp Gly Ala 
    130                 135                 140                 


Glu Gly Arg Asp Val Cys Ala Ala Asn Gly Ser Gly Gly Asp Glu Gly 
145                 150                 155                 160 


Pro Asp Pro Asp Leu Ile Cys Arg Asn Arg Thr Ala Thr Asn Met Met 
                165                 170                 175     


Tyr Leu Leu Leu Ile Gly Ala Gln Val Leu Leu Gly Ile Gly Ala Thr 
            180                 185                 190         


Pro Val Gln Pro Leu Gly Val Ser Tyr Ile Asp Asp His Val Arg Arg 
        195                 200                 205             


Lys Asp Ser Ser Leu Tyr Ile Gly Ile Leu Phe Thr Met Leu Val Phe 
    210                 215                 220                 


Gly Pro Ala Cys Gly Phe Ile Leu Gly Ser Phe Cys Thr Lys Ile Tyr 
225                 230                 235                 240 


Val Asp Ala Val Phe Ile Asp Thr Ser Asn Leu Asp Ile Thr Pro Asp 
                245                 250                 255     


Asp Pro Arg Trp Ile Gly Ala Trp Trp Gly Gly Phe Leu Leu Cys Gly 
            260                 265                 270         


Ala Leu Leu Phe Phe Ser Ser Leu Leu Met Phe Gly Phe Pro Gln Ser 
        275                 280                 285             


Leu Pro Pro His Ser Glu Pro Ala Met Glu Ser Glu Gln Ala Met Leu 
    290                 295                 300                 


Ser Glu Arg Glu Tyr Glu Arg Pro Lys Pro Ser Asn Gly Val Leu Arg 
305                 310                 315                 320 


His Pro Leu Glu Pro Asp Ser Ser Ala Ser Cys Phe Gln Gln Leu Arg 
                325                 330                 335     


Val Ile Pro Lys Val Thr Lys His Leu Leu Ser Asn Pro Val Phe Thr 
            340                 345                 350         


Cys Ile Ile Leu Ala Ala Cys Met Glu Ile Ala Val Val Ala Gly Phe 
        355                 360                 365             


Ala Ala Phe Leu Gly Lys Tyr Leu Glu Gln Gln Phe Asn Leu Thr Thr 
    370                 375                 380                 


Ser Ser Ala Asn Gln Leu Leu Gly Met Thr Ala Ile Pro Cys Ala Cys 
385                 390                 395                 400 


Leu Gly Ile Phe Leu Gly Gly Leu Leu Val Lys Lys Leu Ser Leu Ser 
                405                 410                 415     


Ala Leu Gly Ala Ile Arg Met Ala Met Leu Val Asn Leu Val Ser Thr 
            420                 425                 430         


Ala Cys Tyr Val Ser Phe Leu Phe Leu Gly Cys Asp Thr Gly Pro Val 
        435                 440                 445             


Ala Gly Val Thr Val Pro Tyr Gly Asn Ser Thr Ala Pro Gly Ser Ala 
    450                 455                 460                 


Leu Asp Pro Tyr Ser Pro Cys Asn Asn Asn Cys Glu Cys Gln Thr Asp 
465                 470                 475                 480 


Ser Phe Thr Pro Val Cys Gly Ala Asp Gly Ile Thr Tyr Leu Ser Ala 
                485                 490                 495     


Cys Phe Ala Gly Cys Asn Ser Thr Asn Leu Thr Gly Cys Ala Cys Leu 
            500                 505                 510         


Thr Thr Val Pro Ala Glu Asn Ala Thr Val Val Pro Gly Lys Cys Pro 
        515                 520                 525             


Ser Pro Gly Cys Gln Glu Ala Phe Leu Thr Phe Leu Cys Val Met Cys 
    530                 535                 540                 


Ile Cys Ser Leu Ile Gly Ala Met Ala Gln Thr Pro Ser Val Ile Ile 
545                 550                 555                 560 


Leu Ile Arg Thr Val Ser Pro Glu Leu Lys Ser Tyr Ala Leu Gly Val 
                565                 570                 575     


Leu Phe Leu Leu Leu Arg Leu Leu Gly Phe Ile Pro Pro Pro Leu Ile 
            580                 585                 590         


Phe Gly Ala Gly Ile Asp Ser Thr Cys Leu Phe Trp Ser Thr Phe Cys 
        595                 600                 605             


Gly Glu Gln Gly Ala Cys Val Leu Tyr Asp Asn Val Val Tyr Arg Tyr 
    610                 615                 620                 


Leu Tyr Val Ser Ile Ala Ile Ala Leu Lys Ser Phe Ala Phe Ile Leu 
625                 630                 635                 640 


Tyr Thr Thr Thr Trp Gln Cys Leu Arg Lys Asn Tyr Lys Arg Tyr Ile 
                645                 650                 655     


Lys Asn His Glu Gly Gly Leu Ser Thr Ser Glu Phe Phe Ala Ser Thr 
            660                 665                 670         


Leu Thr Leu Asp Asn Leu Gly Arg Asp Pro Val Pro Ala Asn Gln Thr 
        675                 680                 685             


His Arg Thr Lys Phe Ile Tyr Asn Leu Glu Asp His Glu Trp Cys Glu 
    690                 695                 700                 


Asn Met Glu Ser Val Leu 
705                 710 


<210>  3794
<211>  1111
<212>  PRT
<213>  Homo sapiens

<400>  3794

Met His Trp Leu Pro Ala Gly His Asp Ile Asn Gly Ala Leu Glu Pro 
1               5                   10                  15      


Ser Asn Ile Asp Thr Ser Ile Leu Glu Glu Tyr Ile Ser Lys Glu Asp 
            20                  25                  30          


Ala Ser Asp Leu Cys Phe Pro Asp Ile Ser Ala Pro Ala Ser Ser Ala 
        35                  40                  45              


Ser Tyr Ser His Gly Gln Pro Ala Met Pro Gly Ser Ser Gly Val His 
    50                  55                  60                  


His Leu Ser Pro Pro Gly Gly Gly Pro Ser Pro Gly Arg His Gly Pro 
65                  70                  75                  80  


Leu Pro Pro Pro Gly Tyr Gly Thr Pro Leu Asn Cys Asn Asn Asn Asn 
                85                  90                  95      


Gly Met Gly Ala Ala Pro Lys Pro Phe Pro Gly Gly Thr Gly Pro Pro 
            100                 105                 110         


Ile Lys Ala Glu Pro Lys Ala Pro Tyr Ala Pro Gly Thr Leu Pro Asp 
        115                 120                 125             


Ser Pro Pro Asp Ser Gly Ser Glu Ala Tyr Ser Pro Gln Gln Val Asn 
    130                 135                 140                 


Glu Pro His Leu Leu Arg Thr Ile Thr Pro Glu Thr Leu Cys His Val 
145                 150                 155                 160 


Gly Val Pro Ser Arg Leu Glu His Pro Pro Pro Pro Pro Ala His Leu 
                165                 170                 175     


Pro Gly Pro Pro Pro Pro Pro Pro Pro Pro Pro His Tyr Pro Val Leu 
            180                 185                 190         


Gln Arg Asp Leu Tyr Met Lys Ala Glu Pro Pro Ile Pro His Tyr Ala 
        195                 200                 205             


Ala Met Gly Gln Gly Leu Val Pro Thr Asp Leu His His Thr Gln Gln 
    210                 215                 220                 


Ser Gln Met Leu His Gln Leu Leu Gln Gln His Gly Ala Glu Leu Pro 
225                 230                 235                 240 


Thr His Pro Ser Lys Lys Arg Lys His Ser Glu Ser Pro Pro Ser Thr 
                245                 250                 255     


Leu Asn Ala Gln Met Leu Asn Gly Met Ile Lys Gln Glu Pro Gly Thr 
            260                 265                 270         


Val Thr Ala Leu Pro Leu His Pro Thr Arg Ala Pro Ser Pro Pro Trp 
        275                 280                 285             


Pro Pro Gln Gly Pro Leu Ser Pro Gly Pro Gly Ser Leu Pro Leu Ser 
    290                 295                 300                 


Ile Ala Arg Val Gln Thr Pro Pro Trp His Pro Pro Gly Ala Pro Ser 
305                 310                 315                 320 


Pro Gly Leu Leu Gln Asp Ser Asp Ser Leu Ser Gly Ser Tyr Leu Asp 
                325                 330                 335     


Pro Asn Tyr Gln Ser Ile Lys Trp Gln Pro His Gln Gln Asn Lys Trp 
            340                 345                 350         


Ala Thr Leu Tyr Asp Ala Asn Tyr Lys Glu Leu Pro Met Leu Thr Tyr 
        355                 360                 365             


Arg Val Asp Ala Asp Lys Gly Phe Asn Phe Ser Val Gly Asp Asp Ala 
    370                 375                 380                 


Phe Val Cys Gln Lys Lys Asn His Phe Gln Val Thr Val Tyr Ile Gly 
385                 390                 395                 400 


Met Leu Gly Glu Pro Lys Tyr Val Lys Thr Pro Glu Gly Leu Lys Pro 
                405                 410                 415     


Leu Asp Cys Phe Tyr Leu Lys Leu His Gly Val Lys Leu Glu Ala Leu 
            420                 425                 430         


Asn Gln Ser Ile Asn Ile Glu Gln Ser Gln Ser Asp Arg Ser Lys Arg 
        435                 440                 445             


Pro Phe Asn Pro Val Thr Val Asn Leu Pro Pro Glu Gln Val Thr Lys 
    450                 455                 460                 


Val Thr Val Gly Arg Leu His Phe Ser Glu Thr Thr Ala Asn Asn Met 
465                 470                 475                 480 


Arg Lys Lys Gly Lys Pro Asn Pro Asp Gln Arg Tyr Phe Met Leu Val 
                485                 490                 495     


Val Ala Leu Gln Ala His Ala Gln Asn Gln Asn Tyr Thr Leu Ala Ala 
            500                 505                 510         


Gln Ile Ser Glu Arg Ile Ile Val Arg Ala Ser Asn Pro Gly Gln Phe 
        515                 520                 525             


Glu Ser Asp Ser Asp Val Leu Trp Gln Arg Ala Gln Val Pro Asp Thr 
    530                 535                 540                 


Val Phe His His Gly Arg Val Gly Ile Asn Thr Asp Arg Pro Asp Glu 
545                 550                 555                 560 


Ala Leu Val Val His Gly Asn Val Lys Val Met Gly Ser Leu Met His 
                565                 570                 575     


Pro Ser Asp Leu Arg Ala Lys Glu His Val Gln Glu Val Asp Thr Thr 
            580                 585                 590         


Glu Gln Leu Lys Arg Ile Ser Arg Met Arg Leu Val His Tyr Arg Tyr 
        595                 600                 605             


Lys Pro Glu Phe Ala Ala Ser Ala Gly Ile Glu Ala Thr Ala Pro Glu 
    610                 615                 620                 


Thr Gly Val Ile Ala Gln Glu Val Lys Glu Ile Leu Pro Glu Ala Val 
625                 630                 635                 640 


Lys Asp Thr Gly Asp Met Val Phe Ala Asn Gly Lys Thr Ile Glu Asn 
                645                 650                 655     


Phe Leu Val Val Asn Lys Glu Arg Ile Phe Met Glu Asn Val Gly Ala 
            660                 665                 670         


Val Lys Glu Leu Cys Lys Leu Thr Asp Asn Leu Glu Thr Arg Ile Asp 
        675                 680                 685             


Glu Leu Glu Arg Trp Ser His Lys Leu Ala Lys Leu Arg Arg Leu Asp 
    690                 695                 700                 


Ser Leu Lys Ser Thr Gly Ser Ser Gly Ala Phe Ser His Ala Gly Ser 
705                 710                 715                 720 


Gln Phe Ser Arg Ala Gly Ser Val Pro His Lys Lys Arg Pro Pro Lys 
                725                 730                 735     


Val Ala Ser Lys Ser Ser Ser Val Val Pro Asp Gln Ala Cys Ile Ser 
            740                 745                 750         


Gln Arg Phe Leu Gln Gly Thr Ile Ile Ala Leu Val Val Val Met Ala 
        755                 760                 765             


Phe Ser Val Val Ser Met Ser Thr Leu Tyr Val Leu Ser Leu Arg Thr 
    770                 775                 780                 


Glu Glu Asp Leu Val Asp Thr Asp Gly Arg Ser Ser Gln Ser Phe Gly 
785                 790                 795                 800 


Thr Thr Gln Leu Arg Gln Ser Pro Leu Thr Thr Gly Leu Pro Gly Ile 
                805                 810                 815     


Gln Pro Ser Leu Leu Leu Val Thr Thr Ser Leu Thr Ser Ser Ala Pro 
            820                 825                 830         


Gly Ser Ala Val Arg Thr Leu Asp Met Cys Ser Ser His Pro Cys Pro 
        835                 840                 845             


Val Ile Cys Cys Ser Ser Pro Thr Thr Asn Pro Thr Thr Gly Pro Ser 
    850                 855                 860                 


Leu Gly Pro Ser Phe Asn Pro Gly His Val Leu Ser Pro Ser Pro Ser 
865                 870                 875                 880 


Pro Ser Thr Asn Arg Ser Gly Pro Ser Gln Met Ala Leu Leu Pro Val 
                885                 890                 895     


Thr Asn Ile Arg Ala Lys Ser Trp Gly Leu Ser Val Asn Gly Ile Gly 
            900                 905                 910         


His Ser Lys His His Lys Ser Leu Glu Pro Leu Ala Ser Pro Ala Val 
        915                 920                 925             


Pro Phe Pro Gly Gly Gln Gly Lys Ala Lys Asn Ser Pro Ser Leu Gly 
    930                 935                 940                 


Phe His Gly Arg Ala Arg Arg Gly Ala Leu Gln Ser Ser Val Gly Pro 
945                 950                 955                 960 


Ala Glu Pro Thr Trp Ala Gln Gly Gln Ser Glu Pro Val Pro Ser Leu 
                965                 970                 975     


Thr Ser Ile Gln Val Leu Glu Asn Ser Met Ser Ile Thr Ser Gln Tyr 
            980                 985                 990         


Cys Ala Pro Gly Asp Ala Cys Arg  Pro Gly Asn Phe Thr  Tyr His Ile 
        995                 1000                 1005             


Pro Val  Ser Ser Gly Thr Pro  Leu His Leu Ser Leu  Thr Leu Gln 
    1010                 1015                 1020             


Met Asn  Ser Ser Ser Pro Val  Ser Val Val Leu Cys  Ser Leu Arg 
    1025                 1030                 1035             


Ser Lys  Glu Glu Pro Cys Glu  Glu Gly Ser Leu Pro  Gln Ser Leu 
    1040                 1045                 1050             


His Thr  His Gln Asp Thr Gln  Gly Thr Ser His Arg  Trp Pro Ile 
    1055                 1060                 1065             


Thr Ile  Leu Ser Phe Arg Glu  Phe Thr Tyr His Phe  Arg Val Ala 
    1070                 1075                 1080             


Leu Leu  Gly Gln Ala Asn Cys  Ser Ser Glu Ala Leu  Ala Gln Pro 
    1085                 1090                 1095             


Ala Thr  Asp Tyr His Phe His  Phe Tyr Arg Leu Cys  Asp 
    1100                 1105                 1110     


<210>  3795
<211>  674
<212>  PRT
<213>  Homo sapiens

<400>  3795

Met Val Val Ala His Pro Thr Ala Thr Ala Thr Thr Thr Pro Thr Ala 
1               5                   10                  15      


Thr Val Thr Ala Thr Val Val Met Thr Thr Ala Thr Met Asp Leu Arg 
            20                  25                  30          


Asp Trp Leu Phe Leu Cys Tyr Gly Leu Ile Ala Phe Leu Thr Glu Val 
        35                  40                  45              


Ile Asp Ser Thr Thr Cys Pro Ser Val Cys Arg Cys Asp Asn Gly Phe 
    50                  55                  60                  


Ile Tyr Cys Asn Asp Arg Gly Leu Thr Ser Ile Pro Ala Asp Ile Pro 
65                  70                  75                  80  


Asp Asp Ala Thr Thr Leu Tyr Leu Gln Asn Asn Gln Ile Asn Asn Ala 
                85                  90                  95      


Gly Ile Pro Gln Asp Leu Lys Thr Lys Val Asn Val Gln Val Ile Tyr 
            100                 105                 110         


Leu Tyr Glu Asn Asp Leu Asp Glu Phe Pro Ile Asn Leu Pro Arg Ser 
        115                 120                 125             


Leu Arg Glu Leu His Leu Gln Asp Asn Asn Val Arg Thr Ile Ala Arg 
    130                 135                 140                 


Asp Ser Leu Ala Arg Ile Pro Leu Leu Glu Lys Leu His Leu Asp Asp 
145                 150                 155                 160 


Asn Ser Val Ser Thr Val Ser Ile Glu Glu Asp Ala Phe Ala Asp Ser 
                165                 170                 175     


Lys Gln Leu Lys Leu Leu Phe Leu Ser Arg Asn His Leu Ser Ser Ile 
            180                 185                 190         


Pro Ser Gly Leu Pro His Thr Leu Glu Glu Leu Arg Leu Asp Asp Asn 
        195                 200                 205             


Arg Ile Ser Thr Ile Pro Leu His Ala Phe Lys Gly Leu Asn Ser Leu 
    210                 215                 220                 


Arg Arg Leu Val Leu Asp Gly Asn Leu Leu Ala Asn Gln Arg Ile Ala 
225                 230                 235                 240 


Asp Asp Thr Phe Ser Arg Leu Gln Asn Leu Thr Glu Leu Ser Leu Val 
                245                 250                 255     


Arg Asn Ser Leu Ala Ala Pro Pro Leu Asn Leu Pro Ser Ala His Leu 
            260                 265                 270         


Gln Lys Leu Tyr Leu Gln Asp Asn Ala Ile Ser His Ile Pro Tyr Asn 
        275                 280                 285             


Thr Leu Ala Lys Met Arg Glu Leu Glu Arg Leu Asp Leu Ser Asn Asn 
    290                 295                 300                 


Asn Leu Thr Thr Leu Pro Arg Gly Leu Phe Asp Asp Leu Gly Asn Leu 
305                 310                 315                 320 


Ala Gln Leu Leu Leu Arg Asn Asn Pro Trp Phe Cys Gly Cys Asn Leu 
                325                 330                 335     


Met Trp Leu Arg Asp Trp Val Lys Ala Arg Ala Ala Val Val Asn Val 
            340                 345                 350         


Arg Gly Leu Met Cys Gln Gly Pro Glu Lys Val Arg Gly Met Ala Ile 
        355                 360                 365             


Lys Asp Ile Thr Ser Glu Met Asp Glu Cys Phe Glu Thr Gly Pro Gln 
    370                 375                 380                 


Gly Gly Val Ala Asn Ala Ala Ala Lys Thr Thr Ala Ser Asn His Ala 
385                 390                 395                 400 


Ser Ala Thr Thr Pro Gln Gly Ser Leu Phe Thr Leu Lys Ala Lys Arg 
                405                 410                 415     


Pro Gly Leu Arg Leu Pro Asp Ser Asn Ile Asp Tyr Pro Met Ala Thr 
            420                 425                 430         


Gly Asp Gly Ala Lys Thr Leu Ala Ile His Val Lys Ala Leu Thr Ala 
        435                 440                 445             


Asp Ser Ile Arg Ile Thr Trp Lys Ala Thr Leu Pro Ala Ser Ser Phe 
    450                 455                 460                 


Arg Leu Ser Trp Leu Arg Leu Gly His Ser Pro Ala Val Gly Ser Ile 
465                 470                 475                 480 


Thr Glu Thr Leu Val Gln Gly Asp Lys Thr Glu Tyr Leu Leu Thr Ala 
                485                 490                 495     


Leu Glu Pro Lys Ser Thr Tyr Ile Ile Cys Met Val Thr Met Glu Thr 
            500                 505                 510         


Ser Asn Ala Tyr Val Ala Asp Glu Thr Pro Val Cys Ala Lys Ala Glu 
        515                 520                 525             


Thr Ala Asp Ser Tyr Gly Pro Thr Thr Thr Leu Asn Gln Glu Gln Asn 
    530                 535                 540                 


Ala Gly Pro Met Ala Ser Leu Pro Leu Ala Gly Ile Ile Gly Gly Ala 
545                 550                 555                 560 


Val Ala Leu Val Phe Leu Phe Leu Val Leu Gly Ala Ile Cys Trp Tyr 
                565                 570                 575     


Val His Gln Ala Gly Glu Leu Leu Thr Arg Glu Arg Ala Tyr Asn Arg 
            580                 585                 590         


Gly Ser Arg Lys Lys Asp Asp Tyr Met Glu Ser Gly Thr Lys Lys Asp 
        595                 600                 605             


Asn Ser Ile Leu Glu Ile Arg Gly Pro Gly Leu Gln Met Leu Pro Ile 
    610                 615                 620                 


Asn Pro Tyr Arg Ala Lys Glu Glu Tyr Val Val His Thr Ile Phe Pro 
625                 630                 635                 640 


Ser Asn Gly Ser Ser Leu Cys Lys Ala Thr His Thr Ile Gly Tyr Gly 
                645                 650                 655     


Thr Thr Arg Gly Tyr Arg Asp Gly Gly Ile Pro Asp Ile Asp Tyr Ser 
            660                 665                 670         


Tyr Thr 
        


<210>  3796
<211>  649
<212>  PRT
<213>  Homo sapiens

<400>  3796

Met Ile Ser Ala Ala Trp Ser Ile Phe Leu Ile Gly Thr Lys Ile Gly 
1               5                   10                  15      


Leu Phe Leu Gln Val Ala Pro Leu Ser Val Met Ala Lys Ser Cys Pro 
            20                  25                  30          


Ser Val Cys Arg Cys Asp Ala Gly Phe Ile Tyr Cys Asn Asp Arg Phe 
        35                  40                  45              


Leu Thr Ser Ile Pro Thr Gly Ile Pro Glu Asp Ala Thr Thr Leu Tyr 
    50                  55                  60                  


Leu Gln Asn Asn Gln Ile Asn Asn Ala Gly Ile Pro Ser Asp Leu Lys 
65                  70                  75                  80  


Asn Leu Leu Lys Val Glu Arg Ile Tyr Leu Tyr His Asn Ser Leu Asp 
                85                  90                  95      


Glu Phe Pro Thr Asn Leu Pro Lys Tyr Val Lys Glu Leu His Leu Gln 
            100                 105                 110         


Glu Asn Asn Ile Arg Thr Ile Thr Tyr Asp Ser Leu Ser Lys Ile Pro 
        115                 120                 125             


Tyr Leu Glu Glu Leu His Leu Asp Asp Asn Ser Val Ser Ala Val Ser 
    130                 135                 140                 


Ile Glu Glu Gly Ala Phe Arg Asp Ser Asn Tyr Leu Arg Leu Leu Phe 
145                 150                 155                 160 


Leu Ser Arg Asn His Leu Ser Thr Ile Pro Trp Gly Leu Pro Arg Thr 
                165                 170                 175     


Ile Glu Glu Leu Arg Leu Asp Asp Asn Arg Ile Ser Thr Ile Ser Ser 
            180                 185                 190         


Pro Ser Leu Gln Gly Leu Thr Ser Leu Lys Arg Leu Val Leu Asp Gly 
        195                 200                 205             


Asn Leu Leu Asn Asn His Gly Leu Gly Asp Lys Val Phe Phe Asn Leu 
    210                 215                 220                 


Val Asn Leu Thr Glu Leu Ser Leu Val Arg Asn Ser Leu Thr Ala Ala 
225                 230                 235                 240 


Pro Val Asn Leu Pro Gly Thr Asn Leu Arg Lys Leu Tyr Leu Gln Asp 
                245                 250                 255     


Asn His Ile Asn Arg Val Pro Pro Asn Ala Phe Ser Tyr Leu Arg Gln 
            260                 265                 270         


Leu Tyr Arg Leu Asp Met Ser Asn Asn Asn Leu Ser Asn Leu Pro Gln 
        275                 280                 285             


Gly Ile Phe Asp Asp Leu Asp Asn Ile Thr Gln Leu Ile Leu Arg Asn 
    290                 295                 300                 


Asn Pro Trp Tyr Cys Gly Cys Lys Met Lys Trp Val Arg Asp Trp Leu 
305                 310                 315                 320 


Gln Ser Leu Pro Val Lys Val Asn Val Arg Gly Leu Met Cys Gln Ala 
                325                 330                 335     


Pro Glu Lys Val Arg Gly Met Ala Ile Lys Asp Leu Asn Ala Glu Leu 
            340                 345                 350         


Phe Asp Cys Lys Asp Ser Gly Ile Val Ser Thr Ile Gln Ile Thr Thr 
        355                 360                 365             


Ala Ile Pro Asn Thr Val Tyr Pro Ala Gln Gly Gln Trp Pro Ala Pro 
    370                 375                 380                 


Val Thr Lys Gln Pro Asp Ile Lys Asn Pro Lys Leu Thr Lys Asp His 
385                 390                 395                 400 


Gln Thr Thr Gly Ser Pro Ser Arg Lys Thr Ile Thr Ile Thr Val Lys 
                405                 410                 415     


Ser Val Thr Ser Asp Thr Ile His Ile Ser Trp Lys Leu Ala Leu Pro 
            420                 425                 430         


Met Thr Ala Leu Arg Leu Ser Trp Leu Lys Leu Gly His Ser Pro Ala 
        435                 440                 445             


Phe Gly Ser Ile Thr Glu Thr Ile Val Thr Gly Glu Arg Ser Glu Tyr 
    450                 455                 460                 


Leu Val Thr Ala Leu Glu Pro Asp Ser Pro Tyr Lys Val Cys Met Val 
465                 470                 475                 480 


Pro Met Glu Thr Ser Asn Leu Tyr Leu Phe Asp Glu Thr Pro Val Cys 
                485                 490                 495     


Ile Glu Thr Glu Thr Ala Pro Leu Arg Met Tyr Asn Pro Thr Thr Thr 
            500                 505                 510         


Leu Asn Arg Glu Gln Glu Lys Glu Pro Tyr Lys Asn Pro Asn Leu Pro 
        515                 520                 525             


Leu Ala Ala Ile Ile Gly Gly Ala Val Ala Leu Val Thr Ile Ala Leu 
    530                 535                 540                 


Leu Ala Leu Val Cys Trp Tyr Val His Arg Asn Gly Ser Leu Phe Ser 
545                 550                 555                 560 


Arg Asn Cys Ala Tyr Ser Lys Gly Arg Arg Arg Lys Asp Asp Tyr Ala 
                565                 570                 575     


Glu Ala Gly Thr Lys Lys Asp Asn Ser Ile Leu Glu Ile Arg Glu Thr 
            580                 585                 590         


Ser Phe Gln Met Leu Pro Ile Ser Asn Glu Pro Ile Ser Lys Glu Glu 
        595                 600                 605             


Phe Val Ile His Thr Ile Phe Pro Pro Asn Gly Met Asn Leu Tyr Lys 
    610                 615                 620                 


Asn Asn His Ser Glu Ser Ser Ser Asn Arg Ser Tyr Arg Asp Ser Gly 
625                 630                 635                 640 


Ile Pro Asp Ser Asp His Ser His Ser 
                645                 


<210>  3797
<211>  731
<212>  PRT
<213>  Homo sapiens

<400>  3797

Met Val Lys Pro Lys Tyr Lys Gly Arg Ser Thr Ile Asn Pro Ser Lys 
1               5                   10                  15      


Ala Ser Thr Asn Pro Asp Arg Val Gln Gly Ala Gly Gly Gln Asn Met 
            20                  25                  30          


Arg Asp Arg Ala Thr Ile Arg Arg Leu Asn Met Tyr Arg Gln Lys Glu 
        35                  40                  45              


Arg Arg Asn Ser Arg Gly Lys Ile Ile Lys Pro Leu Gln Tyr Gln Ser 
    50                  55                  60                  


Thr Val Ala Ser Gly Thr Val Ala Arg Val Glu Pro Asn Ile Lys Trp 
65                  70                  75                  80  


Phe Gly Asn Thr Arg Val Ile Lys Gln Ser Ser Leu Gln Lys Phe Gln 
                85                  90                  95      


Glu Glu Met Asp Thr Val Met Lys Asp Pro Tyr Lys Val Val Met Lys 
            100                 105                 110         


Gln Ser Lys Leu Pro Met Ser Leu Leu His Asp Arg Ile Arg Pro His 
        115                 120                 125             


Asn Leu Lys Val His Ile Leu Asp Thr Glu Ser Phe Glu Thr Thr Phe 
    130                 135                 140                 


Gly Pro Lys Ser Gln Arg Lys Arg Pro Asn Leu Phe Ala Ser Asp Met 
145                 150                 155                 160 


Gln Ser Leu Ile Glu Asn Ala Glu Met Ser Thr Glu Ser Tyr Asp Gln 
                165                 170                 175     


Gly Lys Asp Arg Asp Leu Val Thr Glu Asp Thr Gly Val Arg Asn Glu 
            180                 185                 190         


Ala Gln Glu Glu Ile Tyr Lys Lys Gly Gln Ser Lys Arg Ile Trp Gly 
        195                 200                 205             


Glu Leu Tyr Lys Val Ile Asp Ser Ser Asp Val Val Val Gln Val Leu 
    210                 215                 220                 


Asp Ala Arg Asp Pro Met Gly Thr Arg Ser Pro His Ile Glu Thr Tyr 
225                 230                 235                 240 


Leu Lys Lys Glu Lys Pro Trp Lys His Leu Ile Phe Val Leu Asn Lys 
                245                 250                 255     


Cys Asp Leu Val Pro Thr Trp Ala Thr Lys Arg Trp Val Ala Val Leu 
            260                 265                 270         


Ser Gln Asp Tyr Pro Thr Leu Ala Phe His Ala Ser Leu Thr Asn Pro 
        275                 280                 285             


Phe Gly Lys Gly Ala Phe Ile Gln Leu Leu Arg Gln Phe Gly Lys Leu 
    290                 295                 300                 


His Thr Asp Lys Lys Gln Ile Ser Val Gly Phe Ile Gly Tyr Pro Asn 
305                 310                 315                 320 


Val Gly Lys Ser Ser Val Ile Asn Thr Leu Arg Ser Lys Lys Val Cys 
                325                 330                 335     


Asn Val Ala Pro Ile Ala Gly Glu Thr Lys Val Trp Gln Tyr Ile Thr 
            340                 345                 350         


Leu Met Arg Arg Ile Phe Leu Ile Asp Cys Pro Gly Val Val Tyr Pro 
        355                 360                 365             


Ser Glu Asp Ser Glu Thr Asp Ile Val Leu Lys Gly Val Val Gln Val 
    370                 375                 380                 


Glu Lys Ile Lys Ser Pro Glu Asp His Ile Gly Ala Val Leu Glu Arg 
385                 390                 395                 400 


Ala Lys Pro Glu Tyr Ile Ser Lys Thr Tyr Lys Ile Asp Ser Trp Glu 
                405                 410                 415     


Asn Ala Glu Asp Phe Leu Glu Lys Leu Ala Phe Arg Thr Gly Lys Leu 
            420                 425                 430         


Leu Lys Gly Gly Glu Pro Asp Leu Gln Thr Val Gly Lys Met Val Leu 
        435                 440                 445             


Asn Asp Trp Gln Arg Gly Arg Ile Pro Phe Phe Val Lys Pro Pro Asn 
    450                 455                 460                 


Ala Glu Pro Leu Val Ala Pro Gln Leu Leu Pro Ser Ser Ser Leu Glu 
465                 470                 475                 480 


Val Val Pro Glu Ala Ala Gln Asn Asn Pro Gly Glu Glu Val Thr Glu 
                485                 490                 495     


Thr Ala Gly Glu Gly Ser Glu Ser Ile Ile Lys Glu Glu Thr Glu Glu 
            500                 505                 510         


Asn Ser His Cys Asp Ala Asn Thr Glu Met Gln Gln Ile Leu Thr Arg 
        515                 520                 525             


Val Arg Gln Asn Phe Gly Lys Ile Asn Val Val Pro Gln Phe Ser Gly 
    530                 535                 540                 


Asp Asp Leu Val Pro Val Glu Val Ser Asp Leu Glu Glu Glu Leu Glu 
545                 550                 555                 560 


Ser Phe Ser Asp Glu Glu Glu Glu Glu Gln Glu Gln Gln Arg Asp Asp 
                565                 570                 575     


Ala Glu Glu Ser Ser Ser Glu Pro Glu Glu Glu Asn Val Gly Asn Asp 
            580                 585                 590         


Thr Lys Ala Val Ile Lys Ala Leu Asp Glu Lys Ile Ala Lys Tyr Gln 
        595                 600                 605             


Lys Phe Leu Asp Lys Ala Lys Ala Lys Lys Phe Ser Ala Val Arg Ile 
    610                 615                 620                 


Ser Lys Gly Leu Ser Glu Lys Ile Phe Ala Lys Pro Glu Glu Gln Arg 
625                 630                 635                 640 


Lys Thr Leu Glu Glu Asp Val Asp Asp Arg Ala Pro Ser Lys Lys Gly 
                645                 650                 655     


Lys Lys Arg Lys Ala Gln Arg Glu Glu Glu Gln Glu His Ser Asn Lys 
            660                 665                 670         


Ala Pro Arg Ala Leu Thr Ser Lys Glu Arg Arg Arg Ala Val Arg Gln 
        675                 680                 685             


Gln Arg Pro Lys Lys Val Gly Val Arg Tyr Tyr Glu Thr His Asn Val 
    690                 695                 700                 


Lys Asn Arg Asn Arg Asn Lys Lys Lys Thr Asn Asp Ser Glu Gly Gln 
705                 710                 715                 720 


Lys His Lys Arg Lys Lys Phe Arg Gln Lys Gln 
                725                 730     


<210>  3798
<211>  485
<212>  PRT
<213>  Homo sapiens

<400>  3798

Met Tyr Lys Met Asn Ile Cys Asn Lys Pro Ser Asn Lys Thr Ala Pro 
1               5                   10                  15      


Glu Lys Ser Val Trp Thr Ala Pro Ala Gln Pro Ser Gly Pro Ser Pro 
            20                  25                  30          


Glu Leu Gln Gly Gln Arg Ser Arg Arg Asn Gly Trp Ser Trp Pro Pro 
        35                  40                  45              


His Pro Leu Gln Ile Val Ala Trp Leu Leu Tyr Leu Phe Phe Ala Val 
    50                  55                  60                  


Ile Gly Phe Gly Ile Leu Val Pro Leu Leu Pro His His Trp Val Pro 
65                  70                  75                  80  


Ala Gly Tyr Ala Cys Met Gly Ala Ile Phe Ala Gly His Leu Val Val 
                85                  90                  95      


His Leu Thr Ala Val Ser Ile Asp Pro Ala Asp Ala Asn Val Arg Asp 
            100                 105                 110         


Lys Ser Tyr Ala Gly Pro Leu Pro Ile Phe Asn Arg Ser Gln His Ala 
        115                 120                 125             


His Val Ile Glu Asp Leu His Cys Asn Leu Cys Asn Val Asp Val Ser 
    130                 135                 140                 


Ala Arg Ser Lys His Cys Ser Ala Cys Asn Lys Cys Val Cys Gly Phe 
145                 150                 155                 160 


Asp His His Cys Lys Trp Leu Asn Asn Cys Val Gly Glu Arg Asn Tyr 
                165                 170                 175     


Arg Leu Phe Leu His Ser Val Ala Ser Ala Leu Leu Gly Val Leu Leu 
            180                 185                 190         


Leu Val Leu Val Ala Thr Tyr Val Phe Val Glu Phe Phe Val Asn Pro 
        195                 200                 205             


Met Arg Leu Arg Thr Asn Arg His Phe Glu Val Leu Lys Asn His Thr 
    210                 215                 220                 


Asp Val Trp Phe Val Phe Leu Pro Ala Ala Pro Val Glu Thr Gln Ala 
225                 230                 235                 240 


Pro Ala Ile Leu Ala Leu Ala Ala Leu Leu Ile Leu Leu Gly Leu Leu 
                245                 250                 255     


Ser Thr Ala Leu Leu Gly His Leu Leu Cys Phe His Ile Tyr Leu Met 
            260                 265                 270         


Trp His Lys Leu Thr Thr Tyr Glu Tyr Ile Val Gln His Arg Pro Pro 
        275                 280                 285             


Gln Glu Ala Lys Gly Val His Arg Glu Leu Glu Ser Cys Pro Pro Lys 
    290                 295                 300                 


Met Arg Pro Ile Gln Glu Met Glu Phe Tyr Met Arg Thr Phe Arg His 
305                 310                 315                 320 


Met Arg Pro Glu Pro Pro Gly Gln Ala Gly Pro Ala Ala Val Asn Ala 
                325                 330                 335     


Lys His Ser Arg Pro Ala Ser Pro Asp Pro Thr Pro Gly Arg Arg Asp 
            340                 345                 350         


Cys Ala Gly Pro Pro Val Gln Val Glu Trp Asp Arg Lys Lys Pro Leu 
        355                 360                 365             


Pro Trp Arg Ser Pro Leu Leu Leu Leu Ala Met Trp Gly Pro Gln Ala 
    370                 375                 380                 


Pro Pro Cys Leu Cys Arg Lys Arg Gly Arg Gly Ala Cys Ile Lys Cys 
385                 390                 395                 400 


Glu Arg Leu Arg Pro Arg Ile Arg Arg Arg Gly Leu Gly Pro Pro Ala 
                405                 410                 415     


Ala Ala Pro Ala Arg Arg Arg Ile Pro Arg Thr Pro Ala Leu Cys Thr 
            420                 425                 430         


Pro Leu Ala Leu Pro Ala Pro Thr Thr Arg Arg Arg Gln Ser Pro Trp 
        435                 440                 445             


Thr Arg Phe Gln Trp Arg Arg Arg Ala Trp Ala Ala Pro Leu Trp Pro 
    450                 455                 460                 


Pro Arg Gly Ala Gly Ala Asp Ser Pro Arg Trp Arg Gly Arg Arg Val 
465                 470                 475                 480 


Arg Pro Pro Phe Ser 
                485 


<210>  3799
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  3799

Met Arg Tyr Ala Asp Pro Ser Ala Asn Arg Asp Leu Leu Gly Ser Arg 
1               5                   10                  15      


Thr Leu Leu Phe Ile Phe Ile Cys Ala Phe Ala Leu Val Thr Leu Leu 
            20                  25                  30          


Gln Gln Ile Leu Tyr Gly Arg Asn Tyr Ile Lys Arg Tyr Phe Glu Phe 
        35                  40                  45              


Tyr Glu Gly Pro Phe Glu Tyr Asn Ser Thr Arg Cys Leu Glu Leu Arg 
    50                  55                  60                  


His Glu Ile Leu Glu Val Lys Val Leu Ser Met Val Lys Gln Ser Glu 
65                  70                  75                  80  


Leu Phe Asp Arg Trp Lys Ser Leu Gln Met Cys Lys Trp Ala Met Asn 
                85                  90                  95      


Ile Ser Glu Ala Asn Gln Phe Lys Ser Thr Leu Ser Arg Cys Cys Asn 
            100                 105                 110         


Ala Pro Ala Phe Leu Phe Thr Thr Gln Lys Asn Thr Pro Leu Gly Thr 
        115                 120                 125             


Lys Leu Lys Tyr Glu Val Asp Thr Ser Gly Ile Tyr His Ile Asn Gln 
    130                 135                 140                 


Glu Ile Phe Arg Met Phe Pro Lys Asp Met Pro Tyr Tyr Arg Ser Gln 
145                 150                 155                 160 


Phe Lys Lys Cys Ala Val Val Gly Asn Gly Gly Ile Leu Lys Asn Ser 
                165                 170                 175     


Arg Cys Gly Arg Glu Ile Asn Ser Ala Asp Phe Val Phe Arg Cys Asn 
            180                 185                 190         


Leu Pro Pro Ile Ser Glu Lys Tyr Thr Met Asp Val Gly Val Lys Thr 
        195                 200                 205             


Asp Val Val Thr Val Asn Pro Ser Ile Ile Thr Glu Arg Phe His Lys 
    210                 215                 220                 


Leu Glu Lys Trp Arg Arg Pro Phe Tyr Arg Val Leu Gln Val Tyr Glu 
225                 230                 235                 240 


Asn Ala Ser Val Leu Leu Pro Ala Phe Tyr Asn Thr Arg Asn Thr Asp 
                245                 250                 255     


Val Ser Ile Arg Val Lys Tyr Val Leu Asp Asp Phe Glu Ser Pro Gln 
            260                 265                 270         


Ala Val Tyr Tyr Phe His Pro Gln Tyr Leu Val Asn Val Ser Arg Tyr 
        275                 280                 285             


Trp Leu Ser Leu Gly Val Arg Ala Lys Arg Ile Ser Thr Gly Leu Ile 
    290                 295                 300                 


Leu Val Thr Ala Ala Leu Glu Leu Cys Glu Glu Val His Leu Phe Gly 
305                 310                 315                 320 


Phe Trp Ala Phe Pro Met Asn Pro Ser Gly Leu Tyr Ile Thr His His 
                325                 330                 335     


Tyr Tyr Asp Asn Val Lys Pro Arg Pro Gly Phe His Ala Met Pro Ser 
            340                 345                 350         


Glu Ile Phe Asn Phe Leu His Leu His Ser Arg Gly Ile Leu Arg Val 
        355                 360                 365             


His Thr Gly Thr Cys Ser Cys Cys 
    370                 375     


<210>  3800
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  3800

Met Thr Asn Ser Ser Phe Phe Cys Pro Val Tyr Lys Asp Leu Glu Pro 
1               5                   10                  15      


Phe Thr Tyr Phe Phe Tyr Leu Val Phe Leu Val Gly Ile Ile Gly Ser 
            20                  25                  30          


Cys Phe Ala Thr Trp Ala Phe Ile Gln Lys Asn Thr Asn His Arg Cys 
        35                  40                  45              


Val Ser Ile Tyr Leu Ile Asn Leu Leu Thr Ala Asp Phe Leu Leu Thr 
    50                  55                  60                  


Leu Ala Leu Pro Val Lys Ile Val Val Asp Leu Gly Val Ala Pro Trp 
65                  70                  75                  80  


Lys Leu Lys Ile Phe His Cys Gln Val Thr Ala Cys Leu Ile Tyr Ile 
                85                  90                  95      


Asn Met Tyr Leu Ser Ile Ile Phe Leu Ala Phe Val Ser Ile Asp Arg 
            100                 105                 110         


Cys Leu Gln Leu Thr His Ser Cys Lys Ile Tyr Arg Ile Gln Glu Pro 
        115                 120                 125             


Gly Phe Ala Lys Met Ile Ser Thr Val Val Trp Leu Met Val Leu Leu 
    130                 135                 140                 


Ile Met Val Pro Asn Met Met Ile Pro Ile Lys Asp Ile Lys Glu Lys 
145                 150                 155                 160 


Ser Asn Val Gly Cys Met Glu Phe Lys Lys Glu Phe Gly Arg Asn Trp 
                165                 170                 175     


His Leu Leu Thr Asn Phe Ile Cys Val Ala Ile Phe Leu Asn Phe Ser 
            180                 185                 190         


Ala Ile Ile Leu Ile Ser Asn Cys Leu Val Ile Arg Gln Leu Tyr Arg 
        195                 200                 205             


Asn Lys Asp Asn Glu Asn Tyr Pro Asn Val Lys Lys Ala Leu Ile Asn 
    210                 215                 220                 


Ile Leu Leu Val Thr Thr Gly Tyr Ile Ile Cys Phe Val Pro Tyr His 
225                 230                 235                 240 


Ile Val Arg Ile Pro Tyr Thr Leu Ser Gln Thr Glu Val Ile Thr Asp 
                245                 250                 255     


Cys Ser Thr Arg Ile Ser Leu Phe Lys Ala Lys Glu Ala Thr Leu Leu 
            260                 265                 270         


Leu Ala Val Ser Asn Leu Cys Phe Asp Pro Ile Leu Tyr Tyr His Leu 
        275                 280                 285             


Ser Lys Ala Phe Arg Ser Lys Val Thr Glu Thr Phe Ala Ser Pro Lys 
    290                 295                 300                 


Glu Thr Lys Ala Gln Lys Glu Lys Leu Arg Cys Glu Asn Asn Ala 
305                 310                 315                 


<210>  3801
<211>  429
<212>  PRT
<213>  Homo sapiens

<400>  3801

Met Ala Gly Ser Gly Ala Trp Lys Arg Leu Lys Ser Met Leu Arg Lys 
1               5                   10                  15      


Asp Asp Ala Pro Leu Phe Leu Asn Asp Thr Ser Ala Phe Asp Phe Ser 
            20                  25                  30          


Asp Glu Ala Gly Asp Glu Gly Leu Ser Arg Phe Asn Lys Leu Arg Val 
        35                  40                  45              


Val Val Ala Asp Asp Gly Ser Glu Ala Pro Glu Arg Pro Val Asn Gly 
    50                  55                  60                  


Ala His Pro Thr Leu Gln Ala Asp Asp Asp Ser Leu Leu Asp Gln Asp 
65                  70                  75                  80  


Leu Pro Leu Thr Asn Ser Gln Leu Ser Leu Lys Val Asp Ser Cys Asp 
                85                  90                  95      


Asn Cys Ser Lys Gln Arg Glu Ile Leu Lys Gln Arg Lys Val Lys Ala 
            100                 105                 110         


Arg Leu Thr Ile Ala Ala Val Leu Tyr Leu Leu Phe Met Ile Gly Glu 
        115                 120                 125             


Leu Val Gly Gly Tyr Ile Ala Asn Ser Leu Ala Ile Met Thr Asp Ala 
    130                 135                 140                 


Leu His Met Leu Thr Asp Leu Ser Ala Ile Ile Leu Thr Leu Leu Ala 
145                 150                 155                 160 


Leu Trp Leu Ser Ser Lys Ser Pro Thr Lys Arg Phe Thr Phe Gly Phe 
                165                 170                 175     


His Arg Leu Glu Val Leu Ser Ala Met Ile Ser Val Leu Leu Val Tyr 
            180                 185                 190         


Ile Leu Met Gly Phe Leu Leu Tyr Glu Ala Val Gln Arg Thr Ile His 
        195                 200                 205             


Met Asn Tyr Glu Ile Asn Gly Asp Ile Met Leu Ile Thr Ala Ala Val 
    210                 215                 220                 


Gly Val Ala Val Asn Val Ile Met Gly Phe Leu Leu Asn Gln Ser Gly 
225                 230                 235                 240 


His Arg His Ser His Ser His Ser Leu Pro Ser Asn Ser Pro Thr Arg 
                245                 250                 255     


Gly Ser Gly Cys Glu Arg Asn His Gly Gln Asp Ser Leu Ala Val Arg 
            260                 265                 270         


Ala Ala Phe Val His Ala Leu Gly Asp Leu Val Gln Ser Val Gly Val 
        275                 280                 285             


Leu Ile Ala Ala Tyr Ile Ile Arg Phe Lys Pro Glu Tyr Lys Ile Ala 
    290                 295                 300                 


Asp Pro Ile Cys Thr Tyr Val Phe Ser Leu Leu Val Ala Phe Thr Thr 
305                 310                 315                 320 


Phe Arg Ile Ile Trp Asp Thr Val Val Ile Ile Leu Glu Gly Val Pro 
                325                 330                 335     


Ser His Leu Asn Val Asp Tyr Ile Lys Glu Ala Leu Met Lys Ile Glu 
            340                 345                 350         


Asp Val Tyr Ser Val Glu Asp Leu Asn Ile Trp Ser Leu Thr Ser Gly 
        355                 360                 365             


Lys Ser Thr Ala Ile Val His Ile Gln Leu Ile Pro Gly Ser Ser Ser 
    370                 375                 380                 


Lys Trp Glu Glu Val Gln Ser Lys Ala Asn His Leu Leu Leu Asn Thr 
385                 390                 395                 400 


Phe Gly Met Tyr Arg Cys Thr Ile Gln Leu Gln Ser Tyr Arg Gln Glu 
                405                 410                 415     


Val Asp Arg Thr Cys Ala Asn Cys Gln Ser Ser Ser Pro 
            420                 425                 


<210>  3802
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  3802

Met Ala Ala Ser Gln Val Leu Gly Glu Lys Ile Asn Ile Leu Ser Gly 
1               5                   10                  15      


Glu Thr Val Lys Ala Gly Asp Arg Asp Pro Leu Gly Asn Asp Cys Pro 
            20                  25                  30          


Glu Gln Asp Arg Leu Pro Gln Arg Ser Trp Arg Gln Lys Cys Ala Ser 
        35                  40                  45              


Tyr Val Leu Ala Leu Arg Pro Trp Ser Phe Ser Ala Ser Leu Thr Pro 
    50                  55                  60                  


Val Ala Leu Gly Ser Ala Leu Ala Tyr Arg Ser His Gly Val Leu Asp 
65                  70                  75                  80  


Pro Arg Leu Leu Val Gly Cys Ala Val Ala Val Leu Ala Val His Gly 
                85                  90                  95      


Ala Gly Asn Leu Val Asn Thr Tyr Tyr Asp Phe Ser Lys Gly Ile Asp 
            100                 105                 110         


His Lys Lys Ser Asp Asp Arg Thr Leu Val Asp Arg Ile Leu Glu Pro 
        115                 120                 125             


Gln Asp Val Val Arg Phe Gly Val Phe Leu Tyr Thr Leu Gly Cys Val 
    130                 135                 140                 


Cys Ala Ala Cys Leu Tyr Tyr Leu Ser Pro Leu Lys Leu Glu His Leu 
145                 150                 155                 160 


Ala Leu Ile Tyr Phe Gly Gly Leu Ser Gly Ser Phe Leu Tyr Thr Gly 
                165                 170                 175     


Gly Ile Gly Phe Lys Tyr Val Ala Leu Gly Asp Leu Ile Ile Leu Ile 
            180                 185                 190         


Thr Phe Gly Pro Leu Ala Val Met Phe Ala Tyr Ala Ile Gln Val Gly 
        195                 200                 205             


Ser Leu Ala Ile Phe Pro Leu Val Tyr Ala Ile Pro Leu Ala Leu Ser 
    210                 215                 220                 


Thr Glu Ala Ile Leu His Ser Asn Asn Thr Arg Asp Met Glu Ser Asp 
225                 230                 235                 240 


Arg Glu Ala Gly Ile Val Thr Leu Ala Ile Leu Ile Gly Pro Thr Phe 
                245                 250                 255     


Ser Tyr Ile Leu Tyr Asn Thr Leu Leu Phe Leu Pro Tyr Leu Val Phe 
            260                 265                 270         


Ser Ile Leu Ala Thr His Cys Thr Ile Ser Leu Ala Leu Pro Leu Leu 
        275                 280                 285             


Thr Ile Pro Met Ala Phe Ser Leu Glu Arg Gln Phe Arg Ser Gln Ala 
    290                 295                 300                 


Phe Asn Lys Leu Pro Gln Arg Thr Ala Lys Leu Asn Leu Leu Leu Gly 
305                 310                 315                 320 


Leu Phe Tyr Val Phe Gly Ile Ile Leu Ala Pro Ala Gly Ser Leu Pro 
                325                 330                 335     


Lys Ile 
        


<210>  3803
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  3803

Met Lys His Val Leu Asn Leu Tyr Leu Leu Gly Val Val Leu Thr Leu 
1               5                   10                  15      


Leu Ser Ile Phe Val Arg Val Met Glu Ser Leu Glu Gly Leu Leu Glu 
            20                  25                  30          


Ser Pro Ser Pro Gly Thr Ser Trp Thr Thr Arg Ser Gln Leu Ala Asn 
        35                  40                  45              


Thr Glu Pro Thr Lys Gly Leu Pro Asp His Pro Ser Arg Ser Met 
    50                  55                  60              


<210>  3804
<211>  476
<212>  PRT
<213>  Homo sapiens

<400>  3804

Met Ala Ile Lys Phe Leu Glu Val Ile Lys Pro Phe Cys Val Ile Leu 
1               5                   10                  15      


Pro Glu Ile Gln Lys Pro Glu Arg Lys Ile Gln Phe Lys Glu Lys Val 
            20                  25                  30          


Leu Trp Thr Ala Ile Thr Leu Phe Ile Phe Leu Val Cys Cys Gln Ile 
        35                  40                  45              


Pro Leu Phe Gly Ile Met Ser Ser Asp Ser Ala Asp Pro Phe Tyr Trp 
    50                  55                  60                  


Met Arg Val Ile Leu Ala Ser Asn Arg Gly Thr Leu Met Glu Leu Gly 
65                  70                  75                  80  


Ile Ser Pro Ile Val Thr Ser Gly Leu Ile Met Gln Leu Leu Ala Gly 
                85                  90                  95      


Ala Lys Ile Ile Glu Val Gly Asp Thr Pro Lys Asp Arg Ala Leu Phe 
            100                 105                 110         


Asn Gly Ala Gln Lys Leu Phe Gly Met Ile Ile Thr Ile Gly Gln Ser 
        115                 120                 125             


Ile Val Tyr Val Met Thr Gly Met Tyr Gly Asp Pro Ser Glu Met Gly 
    130                 135                 140                 


Ala Gly Ile Cys Leu Leu Ile Thr Ile Gln Leu Phe Val Ala Gly Leu 
145                 150                 155                 160 


Ile Val Leu Leu Leu Asp Glu Leu Leu Gln Lys Gly Tyr Gly Leu Gly 
                165                 170                 175     


Ser Gly Ile Ser Leu Phe Ile Ala Thr Asn Ile Cys Glu Thr Ile Val 
            180                 185                 190         


Trp Lys Ala Phe Ser Pro Thr Thr Val Asn Thr Gly Arg Gly Met Glu 
        195                 200                 205             


Phe Glu Gly Ala Ile Ile Ala Leu Phe His Leu Leu Ala Thr Arg Thr 
    210                 215                 220                 


Asp Lys Val Arg Ala Leu Arg Glu Ala Phe Tyr Arg Gln Asn Leu Pro 
225                 230                 235                 240 


Asn Leu Met Asn Leu Ile Ala Thr Ile Phe Val Phe Ala Val Val Ile 
                245                 250                 255     


Tyr Phe Gln Gly Phe Arg Val Asp Leu Pro Ile Lys Ser Ala Arg Tyr 
            260                 265                 270         


Arg Gly Gln Tyr Asn Thr Tyr Pro Ile Lys Leu Phe Tyr Thr Ser Asn 
        275                 280                 285             


Ile Pro Ile Ile Leu Gln Ser Ala Leu Val Ser Asn Leu Tyr Val Ile 
    290                 295                 300                 


Ser Gln Met Leu Ser Ala Arg Phe Ser Gly Asn Leu Leu Val Ser Leu 
305                 310                 315                 320 


Leu Gly Thr Trp Ser Asp Thr Ser Ser Gly Gly Pro Ala Arg Ala Tyr 
                325                 330                 335     


Pro Val Gly Gly Leu Cys Tyr Tyr Leu Ser Pro Pro Glu Ser Phe Gly 
            340                 345                 350         


Ser Val Leu Glu Asp Pro Val His Ala Val Val Tyr Ile Val Phe Met 
        355                 360                 365             


Leu Gly Ser Cys Ala Phe Phe Ser Lys Thr Trp Ile Glu Val Ser Gly 
    370                 375                 380                 


Ser Ser Ala Lys Asp Val Ala Lys Gln Leu Lys Glu Gln Gln Met Val 
385                 390                 395                 400 


Met Arg Gly His Arg Glu Thr Ser Met Val His Glu Leu Asn Arg Tyr 
                405                 410                 415     


Ile Pro Thr Ala Ala Ala Phe Gly Gly Leu Cys Ile Gly Ala Leu Ser 
            420                 425                 430         


Val Leu Ala Asp Phe Leu Gly Ala Ile Gly Ser Gly Thr Gly Ile Leu 
        435                 440                 445             


Leu Ala Val Thr Ile Ile Tyr Gln Tyr Phe Glu Ile Phe Val Lys Glu 
    450                 455                 460                 


Gln Ser Glu Val Gly Ser Met Gly Ala Leu Leu Phe 
465                 470                 475     


<210>  3805
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  3805

Met Ala Ala Ala Ala Pro Asn Ala Gly Gly Ser Ala Pro Glu Thr Ala 
1               5                   10                  15      


Gly Ser Ala Glu Ala Pro Leu Gln Tyr Ser Leu Leu Leu Gln Tyr Leu 
            20                  25                  30          


Val Gly Asp Lys Arg Gln Pro Arg Leu Leu Glu Pro Gly Ser Leu Gly 
        35                  40                  45              


Gly Ile Pro Ser Pro Ala Lys Ser Glu Glu Gln Lys Met Ile Glu Lys 
    50                  55                  60                  


Ala Met Glu Ser Cys Ala Phe Lys Ala Ala Leu Ala Cys Val Gly Gly 
65                  70                  75                  80  


Phe Val Leu Gly Gly Ala Phe Gly Val Phe Thr Ala Gly Ile Asp Thr 
                85                  90                  95      


Asn Val Gly Phe Asp Pro Lys Asp Pro Tyr Arg Thr Pro Thr Ala Lys 
            100                 105                 110         


Glu Val Leu Lys Asp Met Gly Gln Arg Gly Met Ser Tyr Ala Lys Asn 
        115                 120                 125             


Phe Ala Ile Val Gly Ala Met Phe Ser Cys Thr Glu Cys Leu Ile Glu 
    130                 135                 140                 


Ser Tyr Arg Gly Thr Ser Asp Trp Lys Asn Ser Val Ile Ser Gly Cys 
145                 150                 155                 160 


Ile Thr Gly Gly Ala Ile Gly Phe Arg Ala Gly Leu Lys Ala Gly Ala 
                165                 170                 175     


Ile Gly Cys Gly Gly Phe Ala Ala Phe Ser Ala Ala Ile Asp Tyr Tyr 
            180                 185                 190         


Leu Arg 
        


<210>  3806
<211>  324
<212>  PRT
<213>  Homo sapiens

<400>  3806

Met Ala Pro Leu Leu Leu Gln Leu Ala Val Leu Gly Ala Ala Leu Ala 
1               5                   10                  15      


Ala Ala Ala Leu Val Leu Ile Ser Ile Val Ala Phe Thr Thr Ala Thr 
            20                  25                  30          


Lys Met Pro Ala Leu His Arg His Glu Glu Glu Lys Phe Phe Leu Asn 
        35                  40                  45              


Ala Lys Gly Gln Lys Glu Thr Leu Pro Ser Ile Trp Asp Ser Pro Thr 
    50                  55                  60                  


Lys Gln Leu Ser Val Val Val Pro Ser Tyr Asn Glu Glu Lys Arg Leu 
65                  70                  75                  80  


Pro Val Met Met Asp Glu Ala Leu Ser Tyr Leu Glu Lys Arg Gln Lys 
                85                  90                  95      


Arg Asp Pro Ala Phe Thr Tyr Glu Val Ile Val Val Asp Asp Gly Ser 
            100                 105                 110         


Lys Asp Gln Thr Ser Lys Val Ala Phe Lys Tyr Cys Gln Lys Tyr Gly 
        115                 120                 125             


Ser Asp Lys Val Arg Val Ile Thr Leu Val Lys Asn Arg Gly Lys Gly 
    130                 135                 140                 


Gly Ala Ile Arg Met Gly Ile Phe Ser Ser Arg Gly Glu Lys Ile Leu 
145                 150                 155                 160 


Met Ala Asp Ala Asp Gly Ala Thr Lys Phe Pro Asp Val Glu Lys Leu 
                165                 170                 175     


Glu Lys Gly Leu Asn Asp Leu Gln Pro Trp Pro Asn Gln Met Ala Ile 
            180                 185                 190         


Ala Cys Gly Ser Arg Ala His Leu Glu Lys Glu Ser Ile Ala Gln Arg 
        195                 200                 205             


Ser Tyr Phe Arg Thr Leu Leu Met Tyr Gly Phe His Phe Leu Val Trp 
    210                 215                 220                 


Phe Leu Cys Val Lys Gly Ile Arg Asp Thr Gln Cys Gly Phe Lys Leu 
225                 230                 235                 240 


Phe Thr Arg Glu Ala Ala Ser Arg Thr Phe Ser Ser Leu His Val Glu 
                245                 250                 255     


Arg Trp Ala Phe Asp Val Glu Leu Leu Tyr Ile Ala Gln Phe Phe Lys 
            260                 265                 270         


Ile Pro Ile Ala Glu Ile Ala Val Asn Trp Thr Glu Ile Glu Gly Ser 
        275                 280                 285             


Lys Leu Val Pro Phe Trp Ser Trp Leu Gln Met Gly Lys Asp Leu Leu 
    290                 295                 300                 


Phe Ile Arg Leu Arg Tyr Leu Thr Gly Ala Trp Arg Leu Glu Gln Thr 
305                 310                 315                 320 


Arg Lys Met Asn 
                


<210>  3807
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  3807

Met Glu Lys Trp Tyr Leu Met Thr Val Val Val Leu Ile Gly Leu Thr 
1               5                   10                  15      


Val Arg Trp Thr Val Ser Leu Asn Ser Tyr Ser Gly Ala Gly Lys Pro 
            20                  25                  30          


Pro Met Phe Gly Asp Tyr Glu Ala Gln Arg His Trp Gln Glu Ile Thr 
        35                  40                  45              


Phe Asn Leu Pro Val Lys Gln Trp Tyr Phe Asn Ser Ser Asp Asn Asn 
    50                  55                  60                  


Leu Gln Tyr Trp Gly Leu Asp Tyr Pro Pro Leu Thr Ala Tyr His Ser 
65                  70                  75                  80  


Leu Leu Cys Ala Tyr Val Ala Lys Phe Ile Asn Pro Asp Trp Ile Ala 
                85                  90                  95      


Leu His Thr Ser Arg Gly Tyr Glu Ser Gln Ala His Lys Leu Phe Met 
            100                 105                 110         


Arg Thr Thr Val Leu Ile Ala Asp Leu Leu Ile Tyr Ile Pro Ala Val 
        115                 120                 125             


Val Leu Tyr Cys Cys Cys Leu Lys Glu Ile Ser Thr Lys Lys Lys Ile 
    130                 135                 140                 


Ala Asn Ala Leu Cys Ile Leu Leu Tyr Pro Gly Leu Ile Leu Ile Asp 
145                 150                 155                 160 


Tyr Gly His Phe Gln Tyr Asn Ser Val Ser Leu Gly Phe Ala Leu Trp 
                165                 170                 175     


Gly Val Leu Gly Ile Ser Cys Asp Cys Asp Leu Leu Gly Ser Leu Ala 
            180                 185                 190         


Phe Cys Leu Ala Ile Asn Tyr Lys Gln Met Glu Leu Tyr His Ala Leu 
        195                 200                 205             


Pro Phe Phe Cys Phe Leu Leu Gly Lys Cys Phe Lys Lys Gly Leu Lys 
    210                 215                 220                 


Gly Lys Gly Phe Val Leu Leu Val Lys Leu Ala Cys Ile Val Val Ala 
225                 230                 235                 240 


Ser Phe Val Leu Cys Trp Leu Pro Phe Phe Thr Glu Arg Glu Gln Thr 
                245                 250                 255     


Leu Gln Val Leu Arg Arg Leu Phe Pro Val Asp Arg Gly Leu Phe Glu 
            260                 265                 270         


Asp Lys Val Ala Asn Ile Trp Cys Ser Phe Asn Val Phe Leu Lys Ile 
        275                 280                 285             


Lys Asp Ile Leu Pro Arg His Ile Gln Leu Ile Met Ser Phe Cys Ser 
    290                 295                 300                 


Thr Phe Leu Ser Leu Leu Pro Ala Cys Ile Lys Leu Ile Leu Gln Pro 
305                 310                 315                 320 


Ser Ser Lys Gly Phe Lys Phe Thr Leu Val Ser Cys Ala Leu Ser Phe 
                325                 330                 335     


Phe Leu Phe Ser Phe Gln Val His Glu Lys Ser Ile Leu Leu Val Ser 
            340                 345                 350         


Leu Pro Val Cys Leu Val Leu Ser Glu Ile Pro Phe Met Ser Thr Trp 
        355                 360                 365             


Phe Leu Leu Val Ser Thr Phe Ser Met Leu Pro Leu Leu Leu Lys Asp 
    370                 375                 380                 


Glu Leu Leu Met Pro Ser Val Val Thr Thr Met Ala Phe Phe Ile Ala 
385                 390                 395                 400 


Cys Val Thr Ser Phe Ser Ile Phe Glu Lys Thr Ser Glu Glu Glu Leu 
                405                 410                 415     


Gln Leu Lys Ser Phe Ser Ile Ser Val Arg Lys Tyr Leu Pro Cys Phe 
            420                 425                 430         


Thr Phe Leu Ser Arg Ile Ile Gln Tyr Leu Phe Leu Ile Ser Val Ile 
        435                 440                 445             


Thr Met Val Leu Leu Thr Leu Met Thr Val Thr Leu Asp Pro Pro Gln 
    450                 455                 460                 


Lys Leu Pro Asp Leu Phe Ser Val Leu Val Cys Phe Val Ser Cys Leu 
465                 470                 475                 480 


Asn Phe Leu Phe Phe Leu Val Tyr Phe Asn Ile Ile Ile Met Trp Asp 
                485                 490                 495     


Ser Lys Ser Gly Arg Asn Gln Lys Lys Ile Ser 
            500                 505         


<210>  3808
<211>  818
<212>  PRT
<213>  Homo sapiens

<400>  3808

Met Ala Gly Thr Arg Arg Lys Ser Leu Gln Asn Arg Gln Val Gly Ser 
1               5                   10                  15      


Leu Leu Ile Phe Leu Cys Ile Ser Val Gly Asp Ala Thr Thr Ile Arg 
            20                  25                  30          


Tyr Ser Val Ala Glu Glu Met Glu Ser Gly Ser Phe Val Ala Asn Val 
        35                  40                  45              


Ala Lys Asp Leu Gly Leu Glu Val Gly Lys Leu Ala Ala Arg Gly Ala 
    50                  55                  60                  


Arg Leu Val Ser Glu Gly Asn Lys Met His Phe Arg Leu His Arg Lys 
65                  70                  75                  80  


Thr Gly Asp Leu Phe Val Lys Glu Lys Leu Asp Arg Glu Ser Leu Cys 
                85                  90                  95      


Gly Lys Ala Asp Pro Cys Val Leu His Phe Glu Val Val Leu Val Glu 
            100                 105                 110         


Pro Leu Gln Ser Phe Arg Ala Glu Val Arg Val Phe Asp Ile Asn Asp 
        115                 120                 125             


Asn Ala Pro Val Phe Leu Asn Lys Glu Pro Leu Leu Lys Ile Pro Glu 
    130                 135                 140                 


Ser Thr Pro Leu Gly Ser Arg Phe Pro Leu Gln Ser Ala Gln Asp Leu 
145                 150                 155                 160 


Asp Val Gly Leu Asn Gly Leu Gln Asn Tyr Thr Leu Ser Ala Asn Gly 
                165                 170                 175     


Tyr Phe His Leu His Thr Arg Phe Cys Ser His Gly Pro Lys Tyr Ala 
            180                 185                 190         


Glu Leu Val Leu Asn Lys Pro Leu Asp Arg Glu Glu Gln Pro Glu Val 
        195                 200                 205             


Asn Leu Thr Ile Thr Ala Val Asp Gly Gly Ser Pro Pro Lys Ser Gly 
    210                 215                 220                 


Thr Ala His Ile His Val Val Val Leu Asp Val Asn Asp His Val Pro 
225                 230                 235                 240 


Gln Phe Ser Arg Leu Val Tyr Arg Ala Gln Val Ser Glu Asn Ser Pro 
                245                 250                 255     


Asn Gly Ser Leu Val Ala Thr Val Thr Ala Val Asp Leu Asp Glu Gly 
            260                 265                 270         


Thr Asn Lys Ala Ile Thr Tyr Ser Leu Ala Gln Asn Pro Glu Ala Ile 
        275                 280                 285             


Leu Lys Thr Phe Gln Ile Asp Pro Gln Asn Gly Glu Val Arg Leu Arg 
    290                 295                 300                 


Gly Pro Leu Asp Phe Glu Ala Ile Glu Thr Tyr Asp Ile Asp Ile Gln 
305                 310                 315                 320 


Ala Thr Asp Gly Gly Gly Leu Ser Ala His Ser Lys Val Leu Val Glu 
                325                 330                 335     


Val Val Asp Val Asn Asp Asn Pro Pro Glu Val Met Val Ser Ser Val 
            340                 345                 350         


Ser Ser Pro Leu Pro Glu Asp Ser Pro Pro Gln Thr Val Val Ala Leu 
        355                 360                 365             


Phe Thr Ile Arg Asp Arg Asp Ile Arg Val Gly Gly Lys Val Thr Cys 
    370                 375                 380                 


Phe Leu Arg Glu Asp Leu Pro Phe Val Ile Lys Pro Thr Phe Gly Asn 
385                 390                 395                 400 


Ser Tyr Ser Leu Val Thr Asp Arg Ser Leu Asp Arg Glu Glu Val Ser 
                405                 410                 415     


Gly Tyr Asn Ile Thr Ile Val Ala Met Asp Thr Gly Pro Pro Ser Leu 
            420                 425                 430         


Ser Ala Glu Thr Met Ile Glu Val Leu Ile Ser Asp Val Asn Asp Asn 
        435                 440                 445             


Pro Pro Ile Phe Arg Glu Asp Ser Tyr Ile Leu Thr Val Arg Glu Asn 
    450                 455                 460                 


Asn Ser Pro Ala Val Phe Ile Gly Lys Val His Ala Glu Asp Leu Asp 
465                 470                 475                 480 


Leu Gly Glu Asn Ala Gln Ile Thr Tyr Ser Leu Leu Pro Pro Lys Asn 
                485                 490                 495     


Gly Asp Leu Ser Val Phe Ala Tyr Ile Ser Ile Asn Ser Gly Asn Gly 
            500                 505                 510         


Lys Leu Tyr Ala Leu Arg Thr Met Asp Tyr Glu Ala Ile Gln Asp Phe 
        515                 520                 525             


Gln Phe Val Val Lys Ala Thr Asp Gly Gly Phe Leu Ser Leu Ser Ser 
    530                 535                 540                 


Gln Val Thr Val Arg Val Val Val Leu Asp Asp Asn Asp Asn Arg Pro 
545                 550                 555                 560 


Met Ile Leu Tyr Pro Leu Gln Asn Gly Thr Leu Pro Cys Asn Asp Leu 
                565                 570                 575     


Val Pro Arg Ser Ala Glu Ala Gly Tyr Leu Val Thr Lys Val Val Ala 
            580                 585                 590         


Val Asp Gly Asp Ser Gly Gln Asn Ser Trp Leu Ser Tyr His Leu Leu 
        595                 600                 605             


Lys Ala Thr Asp Leu Gly Leu Phe Ser Val Gln Arg Gln Asn Gly Glu 
    610                 615                 620                 


Ile His Thr Leu Arg Gln Ile Ser Glu Arg Asp Pro Met Met Gln Lys 
625                 630                 635                 640 


Leu Ile Ile Leu Val Gln Asp His Gly Gln Pro Ala Leu Ser Thr Thr 
                645                 650                 655     


Val Ser Leu Asn Ile Leu Leu Val Asp Gly Phe Ser Glu Pro Tyr Leu 
            660                 665                 670         


Gln Phe Gln Asp Pro Thr Lys His Ser Arg Lys Val Asn Pro Ser Thr 
        675                 680                 685             


Lys Tyr Leu Val Ile Ser Leu Val Ile Leu Ser Phe Leu Phe Leu Leu 
    690                 695                 700                 


Ser Val Ile Val Ile Phe Ile Ile His Val Tyr Gln Lys Ile Lys Tyr 
705                 710                 715                 720 


Arg Glu Lys Phe Thr Ile Gln Glu His Phe Tyr Asp Asp Cys Asn Phe 
                725                 730                 735     


Ser Asn Asn Leu Val Gln Gly Gln Gly Asn Gly Ser Leu Ser Arg Pro 
            740                 745                 750         


Cys Pro Tyr Glu Met Cys Ser Ala Thr Gly Thr Gly Asn Ser Glu Phe 
        755                 760                 765             


Arg Phe Leu Lys Arg Phe Met Pro Asn Phe Pro Phe Pro His Ala Thr 
    770                 775                 780                 


Gly Glu Ile Lys Met Glu Ala Gly Ser Ser Leu Pro Pro Asn Ser Asp 
785                 790                 795                 800 


Arg Asn Lys Ser Gln Arg Leu Glu Gly His Asp Gln Val Ser Asp Asp 
                805                 810                 815     


Tyr Met 
        


<210>  3809
<211>  436
<212>  PRT
<213>  Homo sapiens

<400>  3809

Met Gly Leu Ala Arg Ala Leu Arg Arg Leu Ser Gly Ala Leu Asp Ser 
1               5                   10                  15      


Gly Asp Ser Arg Ala Gly Asp Glu Glu Glu Ala Gly Pro Gly Leu Cys 
            20                  25                  30          


Arg Asn Gly Trp Ala Pro Ala Pro Val Gln Ser Pro Val Gly Arg Arg 
        35                  40                  45              


Arg Gly Arg Phe Val Lys Lys Asp Gly His Cys Asn Val Arg Phe Val 
    50                  55                  60                  


Asn Leu Gly Gly Gln Gly Ala Arg Tyr Leu Ser Asp Leu Phe Thr Thr 
65                  70                  75                  80  


Cys Val Asp Val Arg Trp Arg Trp Met Cys Leu Leu Phe Ser Cys Ser 
                85                  90                  95      


Phe Leu Ala Ser Trp Leu Leu Phe Gly Leu Ala Phe Trp Leu Ile Ala 
            100                 105                 110         


Ser Leu His Gly Asp Leu Ala Ala Pro Pro Pro Pro Ala Pro Cys Phe 
        115                 120                 125             


Ser His Val Ala Ser Phe Leu Ala Ala Phe Leu Phe Ala Leu Glu Thr 
    130                 135                 140                 


Gln Thr Ser Ile Gly Tyr Gly Val Arg Ser Val Thr Glu Glu Cys Pro 
145                 150                 155                 160 


Ala Ala Val Ala Ala Val Val Leu Gln Cys Ile Ala Gly Cys Val Leu 
                165                 170                 175     


Asp Ala Phe Val Val Gly Ala Val Met Ala Lys Met Ala Lys Pro Lys 
            180                 185                 190         


Lys Arg Asn Glu Thr Leu Val Phe Ser Glu Asn Ala Val Val Ala Leu 
        195                 200                 205             


Arg Asp His Arg Leu Cys Leu Met Trp Arg Val Gly Asn Leu Arg Arg 
    210                 215                 220                 


Ser His Leu Val Glu Ala His Val Arg Ala Gln Leu Leu Gln Pro Arg 
225                 230                 235                 240 


Val Thr Pro Glu Gly Glu Tyr Ile Pro Leu Asp His Gln Asp Val Asp 
                245                 250                 255     


Val Gly Phe Asp Gly Gly Thr Asp Arg Ile Phe Leu Val Ser Pro Ile 
            260                 265                 270         


Thr Ile Val His Glu Ile Asp Ser Ala Ser Pro Leu Tyr Glu Leu Gly 
        275                 280                 285             


Arg Ala Glu Leu Ala Arg Ala Asp Phe Glu Leu Val Val Ile Leu Glu 
    290                 295                 300                 


Gly Met Val Glu Ala Thr Ala Met Thr Thr Gln Cys Arg Ser Ser Tyr 
305                 310                 315                 320 


Leu Pro Gly Glu Leu Leu Trp Gly His Arg Phe Glu Pro Val Leu Phe 
                325                 330                 335     


Gln Arg Gly Ser Gln Tyr Glu Val Asp Tyr Arg His Phe His Arg Thr 
            340                 345                 350         


Tyr Glu Val Pro Gly Thr Pro Val Cys Ser Ala Lys Glu Leu Asp Glu 
        355                 360                 365             


Arg Ala Glu Gln Ala Ser His Ser Leu Lys Ser Ser Phe Pro Gly Ser 
    370                 375                 380                 


Leu Thr Ala Phe Cys Tyr Glu Asn Glu Leu Ala Leu Ser Cys Cys Gln 
385                 390                 395                 400 


Glu Glu Asp Glu Asp Asp Glu Thr Glu Glu Gly Asn Gly Val Glu Thr 
                405                 410                 415     


Glu Asp Gly Ala Ala Ser Pro Arg Val Leu Thr Pro Thr Leu Ala Leu 
            420                 425                 430         


Thr Leu Pro Pro 
        435     


<210>  3810
<211>  958
<212>  PRT
<213>  Homo sapiens

<400>  3810

Met Arg Thr His Thr Arg Gly Ala Pro Ser Val Phe Phe Ile Tyr Leu 
1               5                   10                  15      


Leu Cys Phe Val Ser Ala Tyr Ile Thr Asp Glu Asn Pro Glu Val Met 
            20                  25                  30          


Ile Pro Phe Thr Asn Ala Asn Tyr Asp Ser His Pro Met Leu Tyr Phe 
        35                  40                  45              


Ser Arg Ala Glu Val Ala Glu Leu Gln Leu Arg Ala Ala Ser Ser His 
    50                  55                  60                  


Glu His Ile Ala Ala Arg Leu Thr Glu Ala Val His Thr Met Leu Ser 
65                  70                  75                  80  


Ser Pro Leu Glu Tyr Leu Pro Pro Trp Asp Pro Lys Asp Tyr Ser Ala 
                85                  90                  95      


Arg Trp Asn Glu Ile Phe Gly Asn Asn Leu Gly Ala Leu Ala Met Phe 
            100                 105                 110         


Cys Val Leu Tyr Pro Glu Asn Ile Glu Ala Arg Asp Met Ala Lys Asp 
        115                 120                 125             


Tyr Met Glu Arg Met Ala Ala Gln Pro Ser Trp Leu Val Lys Asp Ala 
    130                 135                 140                 


Pro Trp Asp Glu Val Pro Leu Ala His Ser Leu Val Gly Phe Ala Thr 
145                 150                 155                 160 


Ala Tyr Asp Phe Leu Tyr Asn Tyr Leu Ser Lys Thr Gln Gln Glu Lys 
                165                 170                 175     


Phe Leu Glu Val Ile Ala Asn Ala Ser Gly Tyr Met Tyr Glu Thr Ser 
            180                 185                 190         


Tyr Arg Arg Gly Trp Gly Phe Gln Tyr Leu His Asn His Gln Pro Thr 
        195                 200                 205             


Asn Cys Met Ala Leu Leu Thr Gly Ser Leu Val Leu Met Asn Gln Gly 
    210                 215                 220                 


Tyr Leu Gln Glu Ala Tyr Leu Trp Thr Lys Gln Val Leu Thr Ile Met 
225                 230                 235                 240 


Glu Lys Ser Leu Val Leu Leu Arg Glu Val Thr Asp Gly Ser Leu Tyr 
                245                 250                 255     


Glu Gly Val Ala Tyr Gly Ser Tyr Thr Thr Arg Ser Leu Phe Gln Tyr 
            260                 265                 270         


Met Phe Leu Val Gln Arg His Phe Asn Ile Asn His Phe Gly His Pro 
        275                 280                 285             


Trp Leu Lys Gln His Phe Ala Phe Met Tyr Arg Thr Ile Leu Pro Gly 
    290                 295                 300                 


Phe Gln Arg Thr Val Ala Ile Ala Asp Ser Asn Tyr Asn Trp Phe Tyr 
305                 310                 315                 320 


Gly Pro Glu Ser Gln Leu Val Phe Leu Asp Lys Phe Val Met Arg Asn 
                325                 330                 335     


Gly Ser Gly Asn Trp Leu Ala Asp Gln Ile Arg Arg Asn Arg Val Val 
            340                 345                 350         


Glu Gly Pro Gly Thr Pro Ser Lys Gly Gln Arg Trp Cys Thr Leu His 
        355                 360                 365             


Thr Glu Phe Leu Trp Tyr Asp Gly Ser Leu Lys Ser Val Pro Pro Pro 
    370                 375                 380                 


Asp Phe Gly Thr Pro Thr Leu His Tyr Phe Glu Asp Trp Gly Val Val 
385                 390                 395                 400 


Thr Tyr Gly Ser Ala Leu Pro Ala Glu Ile Asn Arg Ser Phe Leu Ser 
                405                 410                 415     


Phe Lys Ser Gly Lys Leu Gly Gly Arg Ala Ile Tyr Asp Ile Val His 
            420                 425                 430         


Arg Asn Lys Tyr Lys Asp Trp Ile Lys Gly Trp Arg Asn Phe Asn Ala 
        435                 440                 445             


Gly His Glu His Pro Asp Gln Asn Ser Phe Thr Phe Ala Pro Asn Gly 
    450                 455                 460                 


Val Pro Phe Ile Thr Glu Ala Leu Tyr Gly Pro Lys Tyr Thr Phe Phe 
465                 470                 475                 480 


Asn Asn Val Leu Met Phe Ser Pro Ala Val Ser Lys Ser Cys Phe Ser 
                485                 490                 495     


Pro Trp Val Gly Gln Val Thr Glu Asp Cys Ser Ser Lys Trp Ser Lys 
            500                 505                 510         


Tyr Lys His Asp Leu Ala Ala Ser Cys Gln Gly Arg Val Val Ala Ala 
        515                 520                 525             


Glu Glu Lys Asn Gly Val Val Phe Ile Arg Gly Glu Gly Val Gly Ala 
    530                 535                 540                 


Tyr Asn Pro Gln Leu Asn Leu Lys Asn Val Gln Arg Asn Leu Ile Leu 
545                 550                 555                 560 


Leu His Pro Gln Leu Leu Leu Leu Val Asp Gln Ile His Leu Gly Glu 
                565                 570                 575     


Glu Ser Pro Leu Glu Thr Ala Ala Ser Phe Phe His Asn Val Asp Val 
            580                 585                 590         


Pro Phe Glu Glu Thr Val Val Asp Gly Val His Gly Ala Phe Ile Arg 
        595                 600                 605             


Gln Arg Asp Gly Leu Tyr Lys Met Tyr Trp Met Asp Asp Thr Gly Tyr 
    610                 615                 620                 


Ser Glu Lys Ala Thr Phe Ala Ser Val Thr Tyr Pro Arg Gly Tyr Pro 
625                 630                 635                 640 


Tyr Asn Gly Thr Asn Tyr Val Asn Val Thr Met His Leu Arg Ser Pro 
                645                 650                 655     


Ile Thr Arg Ala Ala Tyr Leu Phe Ile Gly Pro Ser Ile Asp Val Gln 
            660                 665                 670         


Ser Phe Thr Val His Gly Asp Ser Gln Gln Leu Asp Val Phe Ile Ala 
        675                 680                 685             


Thr Ser Lys His Ala Tyr Ala Thr Tyr Leu Trp Thr Gly Glu Ala Thr 
    690                 695                 700                 


Gly Gln Ser Ala Phe Ala Gln Val Ile Ala Asp Arg His Lys Ile Leu 
705                 710                 715                 720 


Phe Asp Arg Asn Ser Ala Ile Lys Ser Ser Ile Val Pro Glu Val Lys 
                725                 730                 735     


Asp Tyr Ala Ala Ile Val Glu Gln Asn Leu Gln His Phe Lys Pro Val 
            740                 745                 750         


Phe Gln Leu Leu Glu Lys Gln Ile Leu Ser Arg Val Arg Asn Thr Ala 
        755                 760                 765             


Ser Phe Arg Lys Thr Ala Glu Arg Leu Leu Arg Phe Ser Asp Lys Arg 
    770                 775                 780                 


Gln Thr Glu Glu Ala Ile Asp Arg Ile Phe Ala Ile Ser Gln Gln Gln 
785                 790                 795                 800 


Gln Gln Gln Ser Lys Ser Lys Lys Asn Arg Arg Ala Gly Lys Arg Tyr 
                805                 810                 815     


Lys Phe Val Asp Ala Val Pro Asp Ile Phe Ala Gln Ile Glu Val Asn 
            820                 825                 830         


Glu Lys Lys Ile Arg Gln Lys Ala Gln Ile Leu Ala Gln Lys Glu Leu 
        835                 840                 845             


Pro Ile Asp Glu Asp Glu Glu Met Lys Asp Leu Leu Asp Phe Ala Asp 
    850                 855                 860                 


Val Thr Tyr Glu Lys His Lys Asn Gly Gly Leu Ile Lys Gly Arg Phe 
865                 870                 875                 880 


Gly Gln Ala Arg Met Val Thr Thr Thr His Ser Arg Ala Pro Ser Leu 
                885                 890                 895     


Ser Ala Ser Tyr Thr Arg Leu Phe Leu Ile Leu Asn Ile Ala Ile Phe 
            900                 905                 910         


Phe Val Met Leu Ala Met Gln Leu Thr Tyr Phe Gln Arg Ala Gln Ser 
        915                 920                 925             


Leu His Gly Gln Arg Cys Leu Tyr Ala Val Leu Leu Ile Asp Ser Cys 
    930                 935                 940                 


Ile Leu Leu Trp Leu Tyr Ser Ser Cys Ser Gln Ser Gln Cys 
945                 950                 955             


<210>  3811
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  3811

Met Gly Ala Gly Gly Pro Arg Arg Gly Glu Gly Pro Pro Asp Gly Gly 
1               5                   10                  15      


Trp Gly Trp Val Val Leu Gly Ala Cys Phe Val Val Thr Gly Phe Ala 
            20                  25                  30          


Tyr Gly Phe Pro Lys Ala Val Ser Val Phe Phe Arg Ala Leu Met Arg 
        35                  40                  45              


Asp Phe Asp Ala Gly Tyr Ser Asp Thr Ala Trp Val Ser Ser Ile Met 
    50                  55                  60                  


Leu Ala Met Leu Tyr Gly Thr Gly Pro Val Ser Ser Ile Leu Val Thr 
65                  70                  75                  80  


Arg Phe Gly Cys Arg Pro Val Met Leu Ala Gly Gly Leu Leu Ala Ser 
                85                  90                  95      


Ala Gly Met Ile Leu Ala Ser Phe Ala Thr Arg Leu Leu Glu Leu Tyr 
            100                 105                 110         


Leu Thr Ala Gly Val Leu Thr Gly Leu Gly Leu Ala Leu Asn Phe Gln 
        115                 120                 125             


Pro Ser Leu Ile Met Leu Gly Leu Tyr Phe Glu Arg Arg Arg Pro Leu 
    130                 135                 140                 


Ala Asn Gly Leu Ala Ala Ala Gly Ser Pro Val Phe Leu Ser Ala Leu 
145                 150                 155                 160 


Ser Pro Leu Gly Gln Gln Leu Leu Glu Arg Phe Gly Trp Arg Gly Gly 
                165                 170                 175     


Phe Leu Leu Leu Gly Gly Leu Leu Leu His Cys Cys Ala Cys Gly Ala 
            180                 185                 190         


Val Met Arg Pro Pro Pro Gly Pro Gly Pro Arg Pro Arg Arg Asp Ser 
        195                 200                 205             


Ala Gly Asp Arg Ala Gly Asp Ala Pro Gly Glu Ala Glu Ala Asp Gly 
    210                 215                 220                 


Ala Gly Leu Gln Leu Arg Glu Ala Ser Pro Arg Val Arg Pro Arg Arg 
225                 230                 235                 240 


Arg Leu Leu Asp Leu Ala Val Cys Thr Asp Arg Ala Phe Ala Val Tyr 
                245                 250                 255     


Ala Val Thr Lys Phe Leu Met Ala Leu Gly Leu Phe Val Pro Ala Ile 
            260                 265                 270         


Leu Leu Val Asn Tyr Ala Lys Asp Ala Gly Val Pro Asp Thr Asp Ala 
        275                 280                 285             


Ala Phe Leu Leu Ser Ile Val Gly Phe Val Asp Ile Val Ala Arg Pro 
    290                 295                 300                 


Ala Cys Gly Ala Leu Ala Gly Leu Ala Arg Leu Arg Pro His Val Pro 
305                 310                 315                 320 


Tyr Leu Phe Ser Leu Ala Leu Leu Ala Asn Gly Leu Thr Asp Leu Ser 
                325                 330                 335     


Ser Ala Arg Ala Arg Ser Tyr Gly Ala Leu Val Ala Phe Cys Val Ala 
            340                 345                 350         


Phe Gly Leu Ser Tyr Gly Met Val Gly Ala Leu Gln Phe Glu Val Leu 
        355                 360                 365             


Met Ala Ala Val Gly Ala Pro Arg Phe Pro Ser Ala Leu Gly Leu Val 
    370                 375                 380                 


Leu Leu Val Glu Ala Ala Ala Val Leu Ile Gly Pro Pro Ser Ala Gly 
385                 390                 395                 400 


Arg Leu Val Asp Val Leu Lys Asn Tyr Glu Ile Ile Phe Tyr Leu Ala 
                405                 410                 415     


Gly Ser Glu Val Ala Leu Ala Gly Val Phe Met Ala Val Ala Thr Asn 
            420                 425                 430         


Cys Cys Leu Arg Cys Ala Lys Ala Ala Pro Ser Gly Pro Gly Thr Glu 
        435                 440                 445             


Gly Gly Ala Ser Asp Thr Glu Asp Ala Glu Ala Glu Gly Asp Ser Glu 
    450                 455                 460                 


Pro Leu Pro Val Val Ala Glu Glu Pro Gly Asn Leu Glu Ala Leu Glu 
465                 470                 475                 480 


Val Leu Ser Ala Arg Gly Glu Pro Thr Glu Pro Glu Ile Glu Ala Arg 
                485                 490                 495     


Pro Arg Leu Ala Ala Glu Ser Val 
            500                 


<210>  3812
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  3812

Met Ser Arg Thr Ala Tyr Thr Val Gly Ala Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      


Thr Leu Leu Pro Ala Ala Glu Gly Lys Lys Lys Gly Ser Gln Gly Ala 
            20                  25                  30          


Ile Pro Pro Pro Asp Lys Ala Gln His Asn Asp Ser Glu Gln Thr Gln 
        35                  40                  45              


Ser Pro Gln Gln Pro Gly Ser Arg Asn Arg Gly Arg Gly Gln Gly Arg 
    50                  55                  60                  


Gly Thr Ala Met Pro Gly Glu Glu Val Leu Glu Ser Ser Gln Glu Ala 
65                  70                  75                  80  


Leu His Val Thr Glu Arg Lys Tyr Leu Lys Arg Asp Trp Cys Lys Thr 
                85                  90                  95      


Gln Pro Leu Lys Gln Thr Ile His Glu Glu Gly Cys Asn Ser Arg Thr 
            100                 105                 110         


Ile Ile Asn Arg Phe Cys Tyr Gly Gln Cys Asn Ser Phe Tyr Ile Pro 
        115                 120                 125             


Arg His Ile Arg Lys Glu Glu Gly Ser Phe Gln Ser Cys Ser Phe Cys 
    130                 135                 140                 


Lys Pro Lys Lys Phe Thr Thr Met Met Val Thr Leu Asn Cys Pro Glu 
145                 150                 155                 160 


Leu Gln Pro Pro Thr Lys Lys Lys Arg Val Thr Arg Val Lys Gln Cys 
                165                 170                 175     


Arg Cys Ile Ser Ile Asp Leu Asp 
            180                 


<210>  3813
<211>  765
<212>  PRT
<213>  Homo sapiens

<400>  3813

Met Pro Arg Ser Pro Gly Thr Arg Leu Lys Pro Ala Lys Tyr Ile Pro 
1               5                   10                  15      


Val Ala Thr Ala Ala Ala Leu Leu Val Gly Ser Ser Thr Leu Phe Phe 
            20                  25                  30          


Val Phe Thr Cys Pro Trp Leu Thr Arg Ala Val Ser Pro Ala Val Pro 
        35                  40                  45              


Val Tyr Asn Gly Ile Ile Phe Leu Phe Val Leu Ala Asn Phe Ser Met 
    50                  55                  60                  


Ala Thr Phe Met Asp Pro Gly Val Phe Pro Arg Ala Asp Glu Asp Glu 
65                  70                  75                  80  


Asp Lys Glu Asp Asp Phe Arg Ala Pro Leu Tyr Lys Asn Val Asp Val 
                85                  90                  95      


Arg Gly Ile Gln Val Arg Met Lys Trp Cys Ala Thr Cys His Phe Tyr 
            100                 105                 110         


Arg Pro Pro Arg Cys Ser His Cys Ser Val Cys Asp Asn Cys Val Glu 
        115                 120                 125             


Asp Phe Asp His His Cys Pro Trp Val Asn Asn Cys Ile Gly Arg Arg 
    130                 135                 140                 


Asn Tyr Arg Tyr Phe Phe Leu Phe Leu Leu Ser Leu Ser Ala His Met 
145                 150                 155                 160 


Val Gly Val Val Ala Phe Gly Leu Val Tyr Val Leu Asn His Ala Glu 
                165                 170                 175     


Gly Leu Gly Ala Ala His Thr Thr Ile Thr Met Ala Val Met Cys Val 
            180                 185                 190         


Ala Gly Leu Phe Phe Ile Pro Val Ile Gly Leu Thr Gly Phe His Val 
        195                 200                 205             


Val Leu Val Thr Arg Gly Arg Thr Thr Asn Glu Gln Val Thr Gly Lys 
    210                 215                 220                 


Phe Arg Gly Gly Val Asn Pro Phe Thr Arg Gly Cys Cys Gly Asn Val 
225                 230                 235                 240 


Glu His Val Leu Cys Ser Pro Leu Ala Pro Arg Tyr Val Val Glu Pro 
                245                 250                 255     


Pro Arg Leu Pro Leu Ala Val Ser Leu Lys Pro Pro Phe Leu Arg Pro 
            260                 265                 270         


Glu Leu Leu Asp Arg Ala Ala Pro Leu Lys Val Lys Leu Ser Asp Asn 
        275                 280                 285             


Gly Leu Lys Ala Gly Leu Gly Arg Ser Lys Ser Lys Gly Ser Leu Asp 
    290                 295                 300                 


Arg Leu Asp Glu Lys Pro Leu Asp Leu Gly Pro Pro Leu Pro Pro Lys 
305                 310                 315                 320 


Ile Glu Ala Gly Thr Phe Ser Ser Asp Leu Gln Thr Pro Arg Pro Gly 
                325                 330                 335     


Ser Ala Glu Ser Ala Leu Ser Val Gln Arg Thr Ser Pro Pro Thr Pro 
            340                 345                 350         


Ala Met Tyr Lys Phe Arg Pro Ala Phe Pro Thr Gly Pro Lys Val Pro 
        355                 360                 365             


Phe Cys Gly Pro Gly Glu Gln Val Pro Gly Pro Asp Ser Leu Thr Leu 
    370                 375                 380                 


Gly Asp Asp Ser Ile Arg Ser Leu Asp Phe Val Ser Glu Pro Ser Leu 
385                 390                 395                 400 


Asp Leu Pro Asp Tyr Gly Pro Gly Gly Leu His Ala Ala Tyr Pro Pro 
                405                 410                 415     


Ser Pro Pro Leu Ser Ala Ser Asp Ala Phe Ser Gly Ala Leu Arg Ser 
            420                 425                 430         


Leu Ser Leu Lys Ala Ser Ser Arg Arg Gly Gly Asp His Val Ala Leu 
        435                 440                 445             


Gln Pro Leu Arg Ser Glu Gly Gly Pro Pro Thr Pro His Arg Ser Ile 
    450                 455                 460                 


Phe Ala Pro His Ala Leu Pro Asn Arg Asn Gly Ser Leu Ser Tyr Asp 
465                 470                 475                 480 


Ser Leu Leu Asn Pro Gly Ser Pro Gly Gly His Ala Cys Pro Ala His 
                485                 490                 495     


Pro Ala Val Gly Val Ala Gly Tyr His Ser Pro Tyr Leu His Pro Gly 
            500                 505                 510         


Ala Thr Gly Asp Pro Pro Arg Pro Leu Pro Arg Ser Phe Ser Pro Val 
        515                 520                 525             


Leu Gly Pro Arg Pro Arg Glu Pro Ser Pro Val Arg Tyr Asp Asn Leu 
    530                 535                 540                 


Ser Arg Thr Ile Met Ala Ser Ile Gln Glu Arg Lys Asp Arg Glu Glu 
545                 550                 555                 560 


Arg Glu Arg Leu Leu Arg Ser Gln Ala Asp Ser Leu Phe Gly Asp Ser 
                565                 570                 575     


Gly Val Tyr Asp Ala Pro Ser Ser Tyr Ser Leu Gln Gln Ala Ser Val 
            580                 585                 590         


Leu Ser Glu Gly Pro Arg Gly Pro Ala Leu Arg Tyr Gly Ser Arg Asp 
        595                 600                 605             


Asp Leu Val Ala Gly Pro Gly Phe Gly Gly Ala Arg Asn Pro Ala Leu 
    610                 615                 620                 


Gln Thr Ser Leu Ser Ser Leu Ser Ser Ser Val Ser Arg Ala Pro Arg 
625                 630                 635                 640 


Thr Ser Ser Ser Ser Leu Gln Ala Asp Gln Ala Ser Ser Asn Ala Pro 
                645                 650                 655     


Gly Pro Arg Pro Ser Ser Gly Ser His Arg Ser Pro Ala Arg Gln Gly 
            660                 665                 670         


Leu Pro Ser Pro Pro Gly Thr Pro His Ser Pro Ser Tyr Ala Gly Pro 
        675                 680                 685             


Lys Ala Val Ala Phe Ile His Thr Asp Leu Pro Glu Pro Pro Pro Ser 
    690                 695                 700                 


Leu Thr Val Gln Arg Asp His Pro Gln Leu Lys Thr Pro Pro Ser Lys 
705                 710                 715                 720 


Leu Asn Gly Gln Ser Pro Gly Leu Ala Arg Leu Gly Pro Ala Thr Gly 
                725                 730                 735     


Pro Pro Gly Pro Ser Ala Ser Pro Thr Arg His Thr Leu Val Lys Lys 
            740                 745                 750         


Val Ser Gly Val Gly Gly Thr Thr Tyr Glu Ile Ser Val 
        755                 760                 765 


<210>  3814
<211>  492
<212>  PRT
<213>  Homo sapiens

<400>  3814

Met Gly Ser Ala Pro Trp Ala Pro Val Leu Leu Leu Ala Leu Gly Leu 
1               5                   10                  15      


Arg Gly Leu Gln Ala Gly Ala Arg Arg Ala Pro Asp Pro Gly Phe Gln 
            20                  25                  30          


Glu Arg Phe Phe Gln Gln Arg Leu Asp His Phe Asn Phe Glu Arg Phe 
        35                  40                  45              


Gly Asn Lys Thr Phe Pro Gln Arg Phe Leu Val Ser Asp Arg Phe Trp 
    50                  55                  60                  


Val Arg Gly Glu Gly Pro Ile Phe Phe Tyr Thr Gly Asn Glu Gly Asp 
65                  70                  75                  80  


Val Trp Ala Phe Ala Asn Asn Ser Ala Phe Val Ala Glu Leu Ala Ala 
                85                  90                  95      


Glu Arg Gly Ala Leu Leu Val Phe Ala Glu His Arg Tyr Tyr Gly Lys 
            100                 105                 110         


Ser Leu Pro Phe Gly Ala Gln Ser Thr Gln Arg Gly His Thr Glu Leu 
        115                 120                 125             


Leu Thr Val Glu Gln Ala Leu Ala Asp Phe Ala Glu Leu Leu Arg Ala 
    130                 135                 140                 


Leu Arg Arg Asp Leu Gly Ala Gln Asp Ala Pro Ala Ile Ala Phe Gly 
145                 150                 155                 160 


Gly Ser Tyr Gly Gly Met Leu Ser Ala Tyr Leu Arg Met Lys Tyr Pro 
                165                 170                 175     


His Leu Val Ala Gly Ala Leu Ala Ala Ser Ala Pro Val Leu Ala Val 
            180                 185                 190         


Ala Gly Leu Gly Asp Ser Asn Gln Phe Phe Arg Asp Val Thr Ala Asp 
        195                 200                 205             


Phe Glu Gly Gln Ser Pro Lys Cys Thr Gln Gly Val Arg Glu Ala Phe 
    210                 215                 220                 


Arg Gln Ile Lys Asp Leu Phe Leu Gln Gly Ala Tyr Asp Thr Val Arg 
225                 230                 235                 240 


Trp Glu Phe Gly Thr Cys Gln Pro Leu Ser Asp Glu Lys Asp Leu Thr 
                245                 250                 255     


Gln Leu Phe Met Phe Ala Arg Asn Ala Phe Thr Val Leu Ala Met Met 
            260                 265                 270         


Asp Tyr Pro Tyr Pro Thr Asp Phe Leu Gly Pro Leu Pro Ala Asn Pro 
        275                 280                 285             


Val Lys Val Gly Cys Asp Arg Leu Leu Ser Glu Ala Gln Arg Ile Thr 
    290                 295                 300                 


Gly Leu Arg Ala Leu Ala Gly Leu Val Tyr Asn Ala Ser Gly Ser Glu 
305                 310                 315                 320 


His Cys Tyr Asp Ile Tyr Arg Leu Tyr His Ser Cys Ala Asp Pro Thr 
                325                 330                 335     


Gly Cys Gly Thr Gly Pro Asp Ala Arg Ala Trp Asp Tyr Gln Ala Cys 
            340                 345                 350         


Thr Glu Ile Asn Leu Thr Phe Ala Ser Asn Asn Val Thr Asp Met Phe 
        355                 360                 365             


Pro Asp Leu Pro Phe Thr Asp Glu Leu Arg Gln Arg Tyr Cys Leu Asp 
    370                 375                 380                 


Thr Trp Gly Val Trp Pro Arg Pro Asp Trp Leu Leu Thr Ser Phe Trp 
385                 390                 395                 400 


Gly Gly Asp Leu Arg Ala Ala Ser Asn Ile Ile Phe Ser Asn Gly Asn 
                405                 410                 415     


Leu Asp Pro Trp Ala Gly Gly Gly Ile Arg Arg Asn Leu Ser Ala Ser 
            420                 425                 430         


Val Ile Ala Val Thr Ile Gln Gly Gly Ala His His Leu Asp Leu Arg 
        435                 440                 445             


Ala Ser His Pro Glu Asp Pro Ala Ser Val Val Glu Ala Arg Lys Leu 
    450                 455                 460                 


Glu Ala Thr Ile Ile Gly Glu Trp Val Lys Ala Ala Arg Arg Glu Gln 
465                 470                 475                 480 


Gln Pro Ala Leu Arg Gly Gly Pro Arg Leu Ser Leu 
                485                 490         


<210>  3815
<211>  1024
<212>  PRT
<213>  Homo sapiens

<400>  3815

Met Gly Glu Asp Asp Ala Ala Leu Arg Ala Gly Ser Arg Gly Leu Ser 
1               5                   10                  15      


Asp Pro Trp Ala Asp Ser Val Gly Val Arg Pro Arg Thr Thr Glu Arg 
            20                  25                  30          


His Ile Ala Val His Lys Arg Leu Val Leu Ala Phe Ala Val Ser Leu 
        35                  40                  45              


Val Ala Leu Leu Ala Val Thr Met Leu Ala Val Leu Leu Ser Leu Arg 
    50                  55                  60                  


Phe Asp Glu Cys Gly Ala Ser Ala Thr Pro Gly Ala Asp Gly Gly Pro 
65                  70                  75                  80  


Ser Gly Phe Pro Glu Arg Gly Gly Asn Gly Ser Leu Pro Gly Ser Ala 
                85                  90                  95      


Arg Arg Asn His His Ala Gly Gly Asp Ser Trp Gln Pro Glu Ala Gly 
            100                 105                 110         


Gly Val Ala Ser Pro Gly Thr Thr Ser Ala Gln Pro Pro Ser Glu Glu 
        115                 120                 125             


Glu Arg Glu Pro Trp Glu Pro Trp Thr Gln Leu Arg Leu Ser Gly His 
    130                 135                 140                 


Leu Lys Pro Leu His Tyr Asn Leu Met Leu Thr Ala Phe Met Glu Asn 
145                 150                 155                 160 


Phe Thr Phe Ser Gly Glu Val Asn Val Glu Ile Ala Cys Arg Asn Ala 
                165                 170                 175     


Thr Arg Tyr Val Val Leu His Ala Ser Arg Val Ala Val Glu Lys Val 
            180                 185                 190         


Gln Leu Ala Glu Asp Arg Ala Phe Gly Ala Val Pro Val Ala Gly Phe 
        195                 200                 205             


Phe Leu Tyr Pro Gln Thr Gln Val Leu Val Val Val Leu Asn Arg Thr 
    210                 215                 220                 


Leu Asp Ala Gln Arg Asn Tyr Asn Leu Lys Ile Ile Tyr Asn Ala Leu 
225                 230                 235                 240 


Ile Glu Asn Glu Leu Leu Gly Phe Phe Arg Ser Ser Tyr Val Leu His 
                245                 250                 255     


Gly Glu Arg Arg Phe Leu Gly Val Thr Gln Phe Ser Pro Thr His Ala 
            260                 265                 270         


Arg Lys Ala Phe Pro Cys Phe Asp Glu Pro Ile Tyr Lys Ala Thr Phe 
        275                 280                 285             


Lys Ile Ser Ile Lys His Gln Ala Thr Tyr Leu Ser Leu Ser Asn Met 
    290                 295                 300                 


Pro Val Glu Thr Ser Val Phe Glu Glu Asp Gly Trp Val Thr Asp His 
305                 310                 315                 320 


Phe Ser Gln Thr Pro Leu Met Ser Thr Tyr Tyr Leu Ala Trp Ala Ile 
                325                 330                 335     


Cys Asn Phe Thr Tyr Arg Glu Thr Thr Thr Lys Ser Gly Val Val Val 
            340                 345                 350         


Arg Leu Tyr Ala Arg Pro Asp Ala Ile Arg Arg Gly Ser Gly Asp Tyr 
        355                 360                 365             


Ala Leu His Ile Thr Lys Arg Leu Ile Glu Phe Tyr Glu Asp Tyr Phe 
    370                 375                 380                 


Lys Val Pro Tyr Ser Leu Pro Lys Leu Asp Leu Leu Ala Val Pro Lys 
385                 390                 395                 400 


His Pro Tyr Ala Ala Met Glu Asn Trp Gly Leu Ser Ile Phe Val Glu 
                405                 410                 415     


Gln Arg Ile Leu Leu Asp Pro Ser Val Ser Ser Ile Ser Tyr Leu Leu 
            420                 425                 430         


Asp Val Thr Met Val Ile Val His Glu Ile Cys His Gln Trp Phe Gly 
        435                 440                 445             


Asp Leu Val Thr Pro Val Trp Trp Glu Asp Val Trp Leu Lys Glu Gly 
    450                 455                 460                 


Phe Ala His Tyr Phe Glu Phe Val Gly Thr Asp Tyr Leu Tyr Pro Gly 
465                 470                 475                 480 


Trp Asn Met Glu Lys Gln Arg Phe Leu Thr Asp Val Leu His Glu Val 
                485                 490                 495     


Met Leu Leu Asp Gly Leu Ala Ser Ser His Pro Val Ser Gln Glu Val 
            500                 505                 510         


Leu Gln Ala Thr Asp Ile Asp Arg Val Phe Asp Trp Ile Ala Tyr Lys 
        515                 520                 525             


Lys Gly Ala Ala Leu Ile Arg Met Leu Ala Asn Phe Met Gly His Ser 
    530                 535                 540                 


Val Phe Gln Arg Gly Leu Gln Asp Tyr Leu Thr Ile His Lys Tyr Gly 
545                 550                 555                 560 


Asn Ala Ala Arg Asn Asp Leu Trp Asn Thr Leu Ser Glu Ala Leu Lys 
                565                 570                 575     


Arg Asn Gly Lys Tyr Val Asn Ile Gln Glu Val Met Asp Gln Trp Thr 
            580                 585                 590         


Leu Gln Met Gly Tyr Pro Val Ile Thr Ile Leu Gly Asn Thr Thr Ala 
        595                 600                 605             


Glu Asn Arg Ile Ile Ile Thr Gln Gln His Phe Ile Tyr Asp Ile Ser 
    610                 615                 620                 


Ala Lys Thr Lys Ala Leu Lys Leu Gln Asn Asn Ser Tyr Leu Trp Gln 
625                 630                 635                 640 


Ile Pro Leu Thr Ile Val Val Gly Asn Arg Ser His Val Ser Ser Glu 
                645                 650                 655     


Ala Ile Ile Trp Val Ser Asn Lys Ser Glu His His Arg Ile Thr Tyr 
            660                 665                 670         


Leu Asp Lys Gly Ser Trp Leu Leu Gly Asn Ile Asn Gln Thr Gly Tyr 
        675                 680                 685             


Phe Arg Val Asn Tyr Asp Leu Arg Asn Trp Arg Leu Leu Ile Asp Gln 
    690                 695                 700                 


Leu Ile Arg Asn His Glu Val Leu Ser Val Ser Asn Arg Ala Gly Leu 
705                 710                 715                 720 


Ile Asp Asp Ala Phe Ser Leu Ala Arg Ala Gly Tyr Leu Pro Gln Asn 
                725                 730                 735     


Ile Pro Leu Glu Ile Ile Arg Tyr Leu Ser Glu Glu Lys Asp Phe Leu 
            740                 745                 750         


Pro Trp His Ala Ala Ser Arg Ala Leu Tyr Pro Leu Asp Lys Leu Leu 
        755                 760                 765             


Asp Arg Met Glu Asn Tyr Asn Ile Phe Asn Glu Tyr Ile Leu Lys Gln 
    770                 775                 780                 


Val Ala Thr Thr Tyr Ile Lys Leu Gly Trp Pro Lys Asn Asn Phe Asn 
785                 790                 795                 800 


Gly Ser Leu Val Gln Ala Ser Tyr Gln His Glu Glu Leu Arg Arg Glu 
                805                 810                 815     


Val Ile Met Leu Ala Cys Ser Phe Gly Asn Lys His Cys His Gln Gln 
            820                 825                 830         


Ala Ser Thr Leu Ile Ser Asp Trp Ile Ser Ser Asn Arg Asn Arg Ile 
        835                 840                 845             


Pro Leu Asn Val Arg Asp Ile Val Tyr Cys Thr Gly Val Ser Leu Leu 
    850                 855                 860                 


Asp Glu Asp Val Trp Glu Phe Ile Trp Met Lys Phe His Ser Thr Thr 
865                 870                 875                 880 


Ala Val Ser Glu Lys Lys Ile Leu Leu Glu Ala Leu Thr Cys Ser Asp 
                885                 890                 895     


Asp Arg Asn Leu Leu Asn Arg Leu Leu Asn Leu Ser Leu Asn Ser Glu 
            900                 905                 910         


Val Val Leu Asp Gln Asp Ala Ile Asp Val Ile Ile His Val Ala Arg 
        915                 920                 925             


Asn Pro His Gly Arg Asp Leu Ala Trp Lys Phe Phe Arg Asp Lys Trp 
    930                 935                 940                 


Lys Ile Leu Asn Thr Arg Tyr Gly Glu Ala Leu Phe Met Asn Ser Lys 
945                 950                 955                 960 


Leu Ile Ser Gly Val Thr Glu Phe Leu Asn Thr Glu Gly Glu Leu Lys 
                965                 970                 975     


Glu Leu Lys Asn Phe Met Lys Asn Tyr Asp Gly Val Ala Ala Ala Ser 
            980                 985                 990         


Phe Ser Arg Ala Val Glu Thr Val  Glu Ala Asn Val Arg  Trp Lys Met 
        995                 1000                 1005             


Leu Tyr  Gln Asp Glu Leu Phe  Gln Trp Leu Gly Lys  Ala Leu Arg 
    1010                 1015                 1020             


His 
    


<210>  3816
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  3816

Met Gly Arg Arg Arg Ala Pro Glu Leu Tyr Arg Ala Pro Phe Pro Leu 
1               5                   10                  15      


Tyr Ala Leu Gln Val Asp Pro Ser Thr Gly Leu Leu Ile Ala Ala Gly 
            20                  25                  30          


Gly Gly Gly Ala Ala Lys Thr Gly Ile Lys Asn Gly Val His Phe Leu 
        35                  40                  45              


Gln Leu Glu Leu Ile Asn Gly Arg Leu Ser Ala Ser Leu Leu His Ser 
    50                  55                  60                  


His Asp Thr Glu Thr Arg Ala Thr Met Asn Leu Ala Leu Ala Gly Asp 
65                  70                  75                  80  


Ile Leu Ala Ala Gly Gln Asp Ala His Cys Gln Leu Leu Arg Phe Gln 
                85                  90                  95      


Ala His Gln Gln Gln Gly Asn Lys Ala Glu Lys Ala Gly Ser Lys Glu 
            100                 105                 110         


Gln Gly Pro Arg Gln Arg Lys Gly Ala Ala Pro Ala Glu Lys Lys Cys 
        115                 120                 125             


Gly Ala Glu Thr Gln His Glu Gly Leu Glu Leu Arg Val Glu Asn Leu 
    130                 135                 140                 


Gln Ala Val Gln Thr Asp Phe Ser Ser Asp Pro Leu Gln Lys Val Val 
145                 150                 155                 160 


Cys Phe Asn His Asp Asn Thr Leu Leu Ala Thr Gly Gly Thr Asp Gly 
                165                 170                 175     


Tyr Val Arg Val Trp Lys Val Pro Ser Leu Glu Lys Val Leu Glu Phe 
            180                 185                 190         


Lys Ala His Glu Gly Glu Ile Glu Asp Leu Ala Leu Gly Pro Asp Gly 
        195                 200                 205             


Lys Leu Val Thr Val Gly Arg Asp Leu Lys Ala Ser Val Trp Gln Lys 
    210                 215                 220                 


Asp Gln Leu Val Thr Gln Leu His Trp Gln Glu Asn Gly Pro Thr Phe 
225                 230                 235                 240 


Ser Ser Thr Pro Tyr Arg Tyr Gln Ala Cys Arg Phe Gly Gln Val Pro 
                245                 250                 255     


Asp Gln Pro Ala Gly Leu Arg Leu Phe Thr Val Gln Ile Pro His Lys 
            260                 265                 270         


Arg Leu Arg Gln Pro Pro Pro Cys Tyr Leu Thr Ala Trp Asp Gly Ser 
        275                 280                 285             


Asn Phe Leu Pro Leu Arg Thr Lys Ser Cys Gly His Glu Val Val Ser 
    290                 295                 300                 


Cys Leu Asp Val Ser Glu Ser Gly Thr Phe Leu Gly Leu Gly Thr Val 
305                 310                 315                 320 


Thr Gly Ser Val Ala Ile Tyr Ile Ala Phe Ser Leu Gln Cys Leu Tyr 
                325                 330                 335     


Tyr Val Arg Glu Ala His Gly Ile Val Val Thr Asp Val Ala Phe Leu 
            340                 345                 350         


Pro Glu Lys Gly Arg Gly Pro Glu Leu Leu Gly Ser His Glu Thr Ala 
        355                 360                 365             


Leu Phe Ser Val Ala Val Asp Ser Arg Cys Gln Leu His Leu Leu Pro 
    370                 375                 380                 


Ser Arg Arg Ser Val Pro Val Trp Leu Leu Leu Leu Leu Cys Val Gly 
385                 390                 395                 400 


Leu Ile Ile Val Thr Ile Leu Leu Leu Gln Ser Ala Phe Pro Gly Phe 
                405                 410                 415     


Leu 
    


<210>  3817
<211>  1359
<212>  PRT
<213>  Homo sapiens

<400>  3817

Met Ala Glu Ala Gly Leu Arg Gly Trp Leu Leu Trp Ala Leu Leu Leu 
1               5                   10                  15      


Arg Leu Ala Gln Ser Glu Pro Tyr Thr Thr Ile His Gln Pro Gly Tyr 
            20                  25                  30          


Cys Ala Phe Tyr Asp Glu Cys Gly Lys Asn Pro Glu Leu Ser Gly Ser 
        35                  40                  45              


Leu Met Thr Leu Ser Asn Val Ser Cys Leu Ser Asn Thr Pro Ala Arg 
    50                  55                  60                  


Lys Ile Thr Gly Asp His Leu Ile Leu Leu Gln Lys Ile Cys Pro Arg 
65                  70                  75                  80  


Leu Tyr Thr Gly Pro Asn Thr Gln Ala Cys Cys Ser Ala Lys Gln Leu 
                85                  90                  95      


Val Ser Leu Glu Ala Ser Leu Ser Ile Thr Lys Ala Leu Leu Thr Arg 
            100                 105                 110         


Cys Pro Ala Cys Ser Asp Asn Phe Val Asn Leu His Cys His Asn Thr 
        115                 120                 125             


Cys Ser Pro Asn Gln Ser Leu Phe Ile Asn Val Thr Arg Val Ala Gln 
    130                 135                 140                 


Leu Gly Ala Gly Gln Leu Pro Ala Val Val Ala Tyr Glu Ala Phe Tyr 
145                 150                 155                 160 


Gln His Ser Phe Ala Glu Gln Ser Tyr Asp Ser Cys Ser Arg Val Arg 
                165                 170                 175     


Val Pro Ala Ala Ala Thr Leu Ala Val Gly Thr Met Cys Gly Val Tyr 
            180                 185                 190         


Gly Ser Ala Leu Cys Asn Ala Gln Arg Trp Leu Asn Phe Gln Gly Asp 
        195                 200                 205             


Thr Gly Asn Gly Leu Ala Pro Leu Asp Ile Thr Phe His Leu Leu Glu 
    210                 215                 220                 


Pro Gly Gln Ala Val Gly Ser Gly Ile Gln Pro Leu Asn Glu Gly Val 
225                 230                 235                 240 


Ala Arg Cys Asn Glu Ser Gln Gly Asp Asp Val Ala Thr Cys Ser Cys 
                245                 250                 255     


Gln Asp Cys Ala Ala Ser Cys Pro Ala Ile Ala Arg Pro Gln Ala Leu 
            260                 265                 270         


Asp Ser Thr Phe Tyr Leu Gly Gln Met Pro Gly Ser Leu Val Leu Ile 
        275                 280                 285             


Ile Ile Leu Cys Ser Val Phe Ala Val Val Thr Ile Leu Leu Val Gly 
    290                 295                 300                 


Phe Arg Val Ala Pro Ala Arg Asp Lys Ser Lys Met Val Asp Pro Lys 
305                 310                 315                 320 


Lys Gly Thr Ser Leu Ser Asp Lys Leu Ser Phe Ser Thr His Thr Leu 
                325                 330                 335     


Leu Gly Gln Phe Phe Gln Gly Trp Gly Thr Trp Val Ala Ser Trp Pro 
            340                 345                 350         


Leu Thr Ile Leu Val Leu Ser Val Ile Pro Val Val Ala Leu Ala Ala 
        355                 360                 365             


Gly Leu Val Phe Thr Glu Leu Thr Thr Asp Pro Val Glu Leu Trp Ser 
    370                 375                 380                 


Ala Pro Asn Ser Gln Ala Arg Ser Glu Lys Ala Phe His Asp Gln His 
385                 390                 395                 400 


Phe Gly Pro Phe Phe Arg Thr Asn Gln Val Ile Leu Thr Ala Pro Asn 
                405                 410                 415     


Arg Ser Ser Tyr Arg Tyr Asp Ser Leu Leu Leu Gly Pro Lys Asn Phe 
            420                 425                 430         


Ser Gly Ile Leu Asp Leu Asp Leu Leu Leu Glu Leu Leu Glu Leu Gln 
        435                 440                 445             


Glu Arg Leu Arg His Leu Gln Val Trp Ser Pro Glu Ala Gln Arg Asn 
    450                 455                 460                 


Ile Ser Leu Gln Asp Ile Cys Tyr Ala Pro Leu Asn Pro Asp Asn Thr 
465                 470                 475                 480 


Ser Leu Tyr Asp Cys Cys Ile Asn Ser Leu Leu Gln Tyr Phe Gln Asn 
                485                 490                 495     


Asn Arg Thr Leu Leu Leu Leu Thr Ala Asn Gln Thr Leu Met Gly Gln 
            500                 505                 510         


Thr Ser Gln Val Asp Trp Lys Asp His Phe Leu Tyr Cys Ala Asn Ala 
        515                 520                 525             


Pro Leu Thr Phe Lys Asp Gly Thr Ala Leu Ala Leu Ser Cys Met Ala 
    530                 535                 540                 


Asp Tyr Gly Ala Pro Val Phe Pro Phe Leu Ala Ile Gly Gly Tyr Lys 
545                 550                 555                 560 


Gly Lys Asp Tyr Ser Glu Ala Glu Ala Leu Ile Met Thr Phe Ser Leu 
                565                 570                 575     


Asn Asn Tyr Pro Ala Gly Asp Pro Arg Leu Ala Gln Ala Lys Leu Trp 
            580                 585                 590         


Glu Glu Ala Phe Leu Glu Glu Met Arg Ala Phe Gln Arg Arg Met Ala 
        595                 600                 605             


Gly Met Phe Gln Val Thr Phe Met Ala Glu Arg Ser Leu Glu Asp Glu 
    610                 615                 620                 


Ile Asn Arg Thr Thr Ala Glu Asp Leu Pro Ile Phe Ala Thr Ser Tyr 
625                 630                 635                 640 


Ile Val Ile Phe Leu Tyr Ile Ser Leu Ala Leu Gly Ser Tyr Ser Ser 
                645                 650                 655     


Trp Ser Arg Val Met Val Asp Ser Lys Ala Thr Leu Gly Leu Gly Gly 
            660                 665                 670         


Val Ala Val Val Leu Gly Ala Val Met Ala Ala Met Gly Phe Phe Ser 
        675                 680                 685             


Tyr Leu Gly Ile Arg Ser Ser Leu Val Ile Leu Gln Val Val Pro Phe 
    690                 695                 700                 


Leu Val Leu Ser Val Gly Ala Asp Asn Ile Phe Ile Phe Val Leu Glu 
705                 710                 715                 720 


Tyr Gln Arg Leu Pro Arg Arg Pro Gly Glu Pro Arg Glu Val His Ile 
                725                 730                 735     


Gly Arg Ala Leu Gly Arg Val Ala Pro Ser Met Leu Leu Cys Ser Leu 
            740                 745                 750         


Ser Glu Ala Ile Cys Phe Phe Leu Gly Ala Leu Thr Pro Met Pro Ala 
        755                 760                 765             


Val Arg Thr Phe Ala Leu Thr Ser Gly Leu Ala Val Ile Leu Asp Phe 
    770                 775                 780                 


Leu Leu Gln Met Ser Ala Phe Val Ala Leu Leu Ser Leu Asp Ser Lys 
785                 790                 795                 800 


Arg Gln Glu Ala Ser Arg Leu Asp Val Cys Cys Cys Val Lys Pro Gln 
                805                 810                 815     


Glu Leu Pro Pro Pro Gly Gln Gly Glu Gly Leu Leu Leu Gly Phe Phe 
            820                 825                 830         


Gln Lys Ala Tyr Ala Pro Phe Leu Leu His Trp Ile Thr Arg Gly Val 
        835                 840                 845             


Val Leu Leu Leu Phe Leu Ala Leu Phe Gly Val Ser Leu Tyr Ser Met 
    850                 855                 860                 


Cys His Ile Ser Val Gly Leu Asp Gln Glu Leu Ala Leu Pro Lys Asp 
865                 870                 875                 880 


Ser Tyr Leu Leu Asp Tyr Phe Leu Phe Leu Asn Arg Tyr Phe Glu Val 
                885                 890                 895     


Gly Ala Pro Val Tyr Phe Val Thr Thr Leu Gly Tyr Asn Phe Ser Ser 
            900                 905                 910         


Glu Ala Gly Met Asn Ala Ile Cys Ser Ser Ala Gly Cys Asn Asn Phe 
        915                 920                 925             


Ser Phe Thr Gln Lys Ile Gln Tyr Ala Thr Glu Phe Pro Glu Gln Ser 
    930                 935                 940                 


Tyr Leu Ala Ile Pro Ala Ser Ser Trp Val Asp Asp Phe Ile Asp Trp 
945                 950                 955                 960 


Leu Thr Pro Ser Ser Cys Cys Arg Leu Tyr Ile Ser Gly Pro Asn Lys 
                965                 970                 975     


Asp Lys Phe Cys Pro Ser Thr Val Asn Ser Leu Asn Cys Leu Lys Asn 
            980                 985                 990         


Cys Met Ser Ile Thr Met Gly Ser  Val Arg Pro Ser Val  Glu Gln Phe 
        995                 1000                 1005             


His Lys  Tyr Leu Pro Trp Phe  Leu Asn Asp Arg Pro  Asn Ile Lys 
    1010                 1015                 1020             


Cys Pro  Lys Gly Gly Leu Ala  Ala Tyr Ser Thr Ser  Val Asn Leu 
    1025                 1030                 1035             


Thr Ser  Asp Gly Gln Val Leu  Asp Thr Val Ala Ile  Leu Ser Pro 
    1040                 1045                 1050             


Arg Leu  Glu Tyr Ser Gly Thr  Ile Ser Ala His Cys  Asn Leu Tyr 
    1055                 1060                 1065             


Leu Leu  Asp Ser Thr Ser Arg  Phe Met Ala Tyr His  Lys Pro Leu 
    1070                 1075                 1080             


Lys Asn  Ser Gln Asp Tyr Thr  Glu Ala Leu Arg Ala  Ala Arg Glu 
    1085                 1090                 1095             


Leu Ala  Ala Asn Ile Thr Ala  Asp Leu Arg Lys Val  Pro Gly Thr 
    1100                 1105                 1110             


Asp Pro  Ala Phe Glu Val Phe  Pro Tyr Thr Ile Thr  Asn Val Phe 
    1115                 1120                 1125             


Tyr Glu  Gln Tyr Leu Thr Ile  Leu Pro Glu Gly Leu  Phe Met Leu 
    1130                 1135                 1140             


Ser Leu  Cys Leu Val Pro Thr  Phe Ala Val Ser Cys  Leu Leu Leu 
    1145                 1150                 1155             


Gly Leu  Asp Leu Arg Ser Gly  Leu Leu Asn Leu Leu  Ser Ile Val 
    1160                 1165                 1170             


Met Ile  Leu Val Asp Thr Val  Gly Phe Met Ala Leu  Trp Gly Ile 
    1175                 1180                 1185             


Ser Tyr  Asn Ala Val Ser Leu  Ile Asn Leu Val Ser  Ala Val Gly 
    1190                 1195                 1200             


Met Ser  Val Glu Phe Val Ser  His Ile Thr Arg Ser  Phe Ala Ile 
    1205                 1210                 1215             


Ser Thr  Lys Pro Thr Trp Leu  Glu Arg Ala Lys Glu  Ala Thr Ile 
    1220                 1225                 1230             


Ser Met  Gly Ser Ala Val Phe  Ala Gly Val Ala Met  Thr Asn Leu 
    1235                 1240                 1245             


Pro Gly  Ile Leu Val Leu Gly  Leu Ala Lys Ala Gln  Leu Ile Gln 
    1250                 1255                 1260             


Ile Phe  Phe Phe Arg Leu Asn  Leu Leu Ile Thr Leu  Leu Gly Leu 
    1265                 1270                 1275             


Leu His  Gly Leu Val Phe Leu  Pro Val Ile Leu Ser  Tyr Val Gly 
    1280                 1285                 1290             


Pro Asp  Val Asn Pro Ala Leu  Ala Leu Glu Gln Lys  Arg Ala Glu 
    1295                 1300                 1305             


Glu Ala  Val Ala Ala Val Met  Val Ala Ser Cys Pro  Asn His Pro 
    1310                 1315                 1320             


Ser Arg  Val Ser Thr Ala Asp  Asn Ile Tyr Val Asn  His Ser Phe 
    1325                 1330                 1335             


Glu Gly  Ser Ile Lys Gly Ala  Gly Ala Ile Ser Asn  Phe Leu Pro 
    1340                 1345                 1350             


Asn Asn  Gly Arg Gln Phe 
    1355                 


<210>  3818
<211>  1383
<212>  PRT
<213>  Homo sapiens

<400>  3818

Met Tyr Ala Thr Asp Ser Arg Gly His Ser Pro Ala Phe Leu Gln Pro 
1               5                   10                  15      


Gln Asn Gly Asn Ser Arg His Pro Ser Gly Tyr Val Pro Gly Lys Val 
            20                  25                  30          


Val Pro Leu Arg Pro Pro Pro Pro Pro Lys Ser Gln Ala Ser Ala Lys 
        35                  40                  45              


Phe Thr Ser Ile Arg Arg Glu Asp Arg Ala Thr Phe Ala Phe Ser Pro 
    50                  55                  60                  


Glu Glu Gln Gln Ala Gln Arg Glu Ser Gln Lys Gln Lys Arg His Lys 
65                  70                  75                  80  


Asn Thr Phe Ile Cys Phe Ala Ile Thr Ser Phe Ser Phe Phe Ile Ala 
                85                  90                  95      


Leu Ala Ile Ile Leu Gly Ile Ser Ser Lys Tyr Ala Pro Asp Glu Asn 
            100                 105                 110         


Cys Pro Asp Gln Asn Pro Arg Leu Arg Asn Trp Asp Pro Gly Gln Asp 
        115                 120                 125             


Ser Ala Lys Gln Val Val Ile Lys Glu Gly Asp Met Leu Arg Leu Thr 
    130                 135                 140                 


Ser Asp Ala Thr Val His Ser Ile Val Ile Gln Asp Gly Gly Leu Leu 
145                 150                 155                 160 


Val Phe Gly Asp Asn Lys Asp Gly Ser Arg Asn Ile Thr Leu Arg Thr 
                165                 170                 175     


His Tyr Ile Leu Ile Gln Asp Gly Gly Ala Leu His Ile Gly Ala Glu 
            180                 185                 190         


Lys Cys Arg Tyr Lys Ser Lys Ala Thr Ile Thr Leu Tyr Gly Lys Ser 
        195                 200                 205             


Asp Glu Gly Glu Ser Met Pro Thr Phe Gly Lys Lys Phe Ile Gly Val 
    210                 215                 220                 


Glu Ala Gly Gly Thr Leu Glu Leu His Gly Ala Arg Lys Ala Ser Trp 
225                 230                 235                 240 


Thr Leu Leu Ala Arg Thr Leu Asn Ser Ser Gly Leu Pro Phe Gly Ser 
                245                 250                 255     


Tyr Thr Phe Glu Lys Asp Phe Ser Arg Gly Leu Asn Val Arg Val Ile 
            260                 265                 270         


Asp Gln Asp Thr Ala Lys Ile Leu Glu Ser Glu Arg Phe Asp Thr His 
        275                 280                 285             


Glu Tyr Arg Asn Glu Ser Arg Arg Leu Gln Glu Phe Leu Arg Phe Gln 
    290                 295                 300                 


Asp Pro Gly Arg Ile Val Ala Ile Ala Val Gly Asp Ser Ala Ala Lys 
305                 310                 315                 320 


Ser Leu Leu Gln Gly Thr Ile Gln Met Ile Gln Glu Arg Leu Gly Ser 
                325                 330                 335     


Glu Leu Ile Gln Gly Leu Gly Tyr Arg Gln Ala Trp Ala Leu Val Gly 
            340                 345                 350         


Val Ile Asp Gly Gly Ser Thr Ser Cys Asn Glu Ser Val Arg Asn Tyr 
        355                 360                 365             


Glu Asn His Ser Ser Gly Gly Lys Ala Leu Ala Gln Arg Glu Phe Tyr 
    370                 375                 380                 


Thr Val Asp Gly Gln Lys Phe Ser Val Thr Ala Tyr Ser Glu Trp Ile 
385                 390                 395                 400 


Glu Gly Val Ser Leu Ser Gly Phe Arg Val Glu Val Val Asp Gly Val 
                405                 410                 415     


Lys Leu Asn Leu Leu Asp Asp Val Ser Ser Trp Lys Pro Gly Asp Gln 
            420                 425                 430         


Ile Val Val Ala Ser Thr Asp Tyr Ser Met Tyr Gln Ala Glu Glu Phe 
        435                 440                 445             


Thr Leu Leu Pro Cys Ser Glu Cys Ser His Phe Gln Val Lys Val Lys 
    450                 455                 460                 


Glu Thr Pro Gln Phe Leu His Met Gly Glu Ile Ile Asp Gly Val Asp 
465                 470                 475                 480 


Met Arg Ala Glu Val Gly Ile Leu Thr Arg Asn Ile Val Ile Gln Gly 
                485                 490                 495     


Glu Val Glu Asp Ser Cys Tyr Ala Glu Asn Gln Cys Gln Phe Phe Asp 
            500                 505                 510         


Tyr Asp Thr Phe Gly Gly His Ile Met Ile Met Lys Asn Phe Thr Ser 
        515                 520                 525             


Val His Leu Ser Tyr Val Glu Leu Lys His Met Gly Gln Gln Gln Met 
    530                 535                 540                 


Gly Arg Tyr Pro Val His Phe His Leu Cys Gly Asp Val Asp Tyr Lys 
545                 550                 555                 560 


Gly Gly Tyr Arg His Ala Thr Phe Val Asp Gly Leu Ser Ile His His 
                565                 570                 575     


Ser Phe Ser Arg Cys Ile Thr Val His Gly Thr Asn Gly Leu Leu Ile 
            580                 585                 590         


Lys Asp Thr Ile Gly Phe Asp Thr Leu Gly His Cys Phe Phe Leu Glu 
        595                 600                 605             


Asp Gly Ile Glu Gln Arg Asn Thr Leu Phe His Asn Leu Gly Leu Leu 
    610                 615                 620                 


Thr Lys Pro Gly Thr Leu Leu Pro Thr Asp Arg Asn Asn Ser Met Cys 
625                 630                 635                 640 


Thr Thr Met Arg Asp Lys Val Phe Gly Asn Tyr Ile Pro Val Pro Ala 
                645                 650                 655     


Thr Asp Cys Met Ala Val Ser Thr Phe Trp Ile Ala His Pro Asn Asn 
            660                 665                 670         


Asn Leu Ile Asn Asn Ala Ala Ala Gly Ser Gln Asp Ala Gly Ile Trp 
        675                 680                 685             


Tyr Leu Phe His Lys Glu Pro Thr Gly Glu Ser Ser Gly Leu Gln Leu 
    690                 695                 700                 


Leu Ala Lys Pro Glu Leu Thr Pro Leu Gly Ile Phe Tyr Asn Asn Arg 
705                 710                 715                 720 


Val His Ser Asn Phe Lys Ala Gly Leu Phe Ile Asp Lys Gly Val Lys 
                725                 730                 735     


Thr Thr Asn Ser Ser Ala Ala Asp Pro Arg Glu Tyr Leu Cys Leu Asp 
            740                 745                 750         


Asn Ser Ala Arg Phe Arg Pro His Gln Asp Ala Asn Pro Glu Lys Pro 
        755                 760                 765             


Arg Val Ala Ala Leu Ile Asp Arg Leu Ile Ala Phe Lys Asn Asn Asp 
    770                 775                 780                 


Asn Gly Ala Trp Val Arg Gly Gly Asp Ile Ile Val Gln Asn Ser Ala 
785                 790                 795                 800 


Phe Ala Asp Asn Gly Ile Gly Leu Thr Phe Ala Ser Asp Gly Ser Phe 
                805                 810                 815     


Pro Ser Asp Glu Gly Ser Ser Gln Glu Val Ser Glu Ser Leu Phe Val 
            820                 825                 830         


Gly Glu Ser Arg Asn Tyr Gly Phe Gln Gly Gly Gln Asn Lys Tyr Val 
        835                 840                 845             


Gly Thr Gly Gly Ile Asp Gln Lys Pro Arg Thr Leu Pro Arg Asn Arg 
    850                 855                 860                 


Thr Phe Pro Ile Arg Gly Phe Gln Ile Tyr Asp Gly Pro Ile His Leu 
865                 870                 875                 880 


Thr Arg Ser Thr Phe Lys Lys Tyr Val Pro Thr Pro Asp Arg Tyr Ser 
                885                 890                 895     


Ser Ala Ile Gly Phe Leu Met Lys Asn Ser Trp Gln Ile Thr Pro Arg 
            900                 905                 910         


Asn Asn Ile Ser Leu Val Lys Phe Gly Pro His Val Ser Leu Asn Val 
        915                 920                 925             


Phe Phe Gly Lys Pro Gly Pro Trp Phe Glu Asp Cys Glu Met Asp Gly 
    930                 935                 940                 


Asp Lys Asn Ser Ile Phe His Asp Ile Asp Gly Ser Val Thr Gly Tyr 
945                 950                 955                 960 


Lys Asp Ala Tyr Val Gly Arg Met Asp Asn Tyr Leu Ile Arg His Pro 
                965                 970                 975     


Ser Cys Val Asn Val Ser Lys Trp Asn Ala Val Ile Cys Ser Gly Thr 
            980                 985                 990         


Tyr Ala Gln Val Tyr Val Gln Thr  Trp Ser Thr Gln Asn  Leu Ser Met 
        995                 1000                 1005             


Thr Ile  Thr Arg Asp Glu Tyr  Pro Ser Asn Pro Met  Val Leu Arg 
    1010                 1015                 1020             


Gly Ile  Asn Gln Lys Ala Ala  Phe Pro Gln Tyr Gln  Pro Val Val 
    1025                 1030                 1035             


Met Leu  Glu Lys Gly Tyr Thr  Ile His Trp Asn Gly  Pro Ala Pro 
    1040                 1045                 1050             


Arg Thr  Thr Phe Leu Tyr Leu  Val Asn Phe Asn Lys  Asn Asp Trp 
    1055                 1060                 1065             


Ile Arg  Val Gly Leu Cys Tyr  Pro Ser Asn Thr Ser  Phe Gln Val 
    1070                 1075                 1080             


Thr Phe  Gly Tyr Leu Gln Arg  Gln Asn Gly Ser Leu  Ser Lys Ile 
    1085                 1090                 1095             


Glu Glu  Tyr Glu Pro Val His  Ser Leu Glu Glu Leu  Gln Arg Lys 
    1100                 1105                 1110             


Gln Ser  Glu Arg Lys Phe Tyr  Phe Asp Ser Ser Thr  Gly Leu Leu 
    1115                 1120                 1125             


Phe Leu  Tyr Leu Lys Ala Lys  Ser His Arg His Gly  His Ser Tyr 
    1130                 1135                 1140             


Cys Ser  Ser Gln Gly Cys Glu  Arg Val Lys Ile Gln  Ala Ala Thr 
    1145                 1150                 1155             


Asp Ser  Lys Asp Ile Ser Asn  Cys Met Ala Lys Ala  Tyr Pro Gln 
    1160                 1165                 1170             


Tyr Tyr  Arg Lys Pro Ser Val  Val Lys Arg Met Pro  Ala Met Leu 
    1175                 1180                 1185             


Thr Gly  Leu Cys Gln Gly Cys  Gly Thr Arg Gln Val  Val Phe Thr 
    1190                 1195                 1200             


Ser Asp  Pro His Lys Ser Tyr  Leu Pro Val Gln Phe  Gln Ser Pro 
    1205                 1210                 1215             


Asp Lys  Ala Glu Thr Gln Arg  Gly Asp Pro Ser Val  Ile Ser Val 
    1220                 1225                 1230             


Asn Gly  Thr Asp Phe Thr Phe  Arg Ser Ala Gly Val  Leu Leu Leu 
    1235                 1240                 1245             


Val Val  Asp Pro Cys Ser Val  Pro Phe Arg Leu Thr  Glu Lys Thr 
    1250                 1255                 1260             


Val Phe  Pro Leu Ala Asp Val  Ser Arg Ile Glu Glu  Tyr Leu Lys 
    1265                 1270                 1275             


Thr Gly  Ile Pro Pro Arg Ser  Ile Val Leu Leu Ser  Thr Arg Gly 
    1280                 1285                 1290             


Glu Ile  Lys Gln Leu Asn Ile  Ser His Leu Leu Val  Pro Leu Gly 
    1295                 1300                 1305             


Leu Ala  Lys Pro Ala His Leu  Tyr Asp Lys Gly Ser  Thr Ile Phe 
    1310                 1315                 1320             


Leu Gly  Phe Ser Gly Asn Phe  Lys Pro Ser Trp Thr  Lys Leu Phe 
    1325                 1330                 1335             


Thr Ser  Pro Ala Gly Gln Gly  Leu Gly Val Leu Glu  Gln Phe Ile 
    1340                 1345                 1350             


Pro Leu  Gln Leu Asp Glu Tyr  Gly Cys Pro Arg Ala  Thr Thr Val 
    1355                 1360                 1365             


Arg Arg  Arg Asp Leu Glu Leu  Leu Lys Gln Ala Ser  Lys Ala His 
    1370                 1375                 1380             


<210>  3819
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  3819

Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              


Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  


Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  


Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      


Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         


Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             


Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 
    130                 135                 140                 


Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 
                165                 170                 175     


Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 
            180                 185                 190         


Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 
        195                 200                 205             


Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 
    210                 215                 220                 


Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 
225                 230                 235                 240 


Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 
                245                 250                 255     


Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 
            260                 265                 270         


Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 
        275                 280                 285             


Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 
    290                 295                 300                 


Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 
305                 310                 315                 320 


Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 
                325                 330                 335     


Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 
            340                 345                 350         


Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 
        355                 360                 365             


Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 
    370                 375                 380                 


Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 
385                 390                 395                 400 


Val Asn Lys Gly His Glu Met Ser Pro Gln Ala Pro Arg Arg Pro Leu 
                405                 410                 415     


Pro Gln Val Ala Thr Leu Ile Asp Arg Phe Val Lys Gly Arg Gly Gln 
            420                 425                 430         


Leu Asp Lys Asp Thr Leu Asp Thr Leu Thr Ala Phe Tyr Pro Gly Tyr 
        435                 440                 445             


Leu Cys Ser Leu Ser Pro Glu Glu Leu Ser Ser Val Pro Pro Ser Ser 
    450                 455                 460                 


Ile Trp Ala Val Arg Pro Gln Asp Leu Asp Thr Cys Asp Pro Arg Gln 
465                 470                 475                 480 


Leu Asp Val Leu Tyr Pro Lys Ala Arg Leu Ala Phe Gln Asn Met Asn 
                485                 490                 495     


Gly Ser Glu Tyr Phe Val Lys Ile Gln Ser Phe Leu Gly Gly Ala Pro 
            500                 505                 510         


Thr Glu Asp Leu Lys Ala Leu Ser Gln Gln Asn Val Ser Met Asp Leu 
        515                 520                 525             


Ala Thr Phe Met Lys Leu Arg Thr Asp Ala Val Leu Pro Leu Thr Val 
    530                 535                 540                 


Ala Glu Val Gln Lys Leu Leu Gly Pro His Val Glu Gly Leu Lys Ala 
545                 550                 555                 560 


Glu Glu Arg His Arg Pro Val Arg Asp Trp Ile Leu Arg Gln Arg Gln 
                565                 570                 575     


Asp Asp Leu Asp Thr Leu Gly Leu Gly Leu Gln Gly Gly Ile Pro Asn 
            580                 585                 590         


Gly Tyr Leu Val Leu Asp Leu Ser Met Gln Glu Ala Leu Ser Gly Thr 
        595                 600                 605             


Pro Cys Leu Leu Gly Pro Gly Pro Val Leu Thr Val Leu Ala Leu Leu 
    610                 615                 620                 


Leu Ala Ser Thr Leu Ala 
625                 630 


<210>  3820
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  3820

Met Asn Lys Gln Arg Gly Thr Tyr Ser Glu Val Ser Leu Ala Gln Asp 
1               5                   10                  15      


Pro Lys Arg Gln Gln Arg Lys Leu Lys Gly Asn Lys Ile Ser Ile Ser 
            20                  25                  30          


Gly Thr Lys Gln Glu Ile Phe Gln Val Glu Leu Asn Leu Gln Asn Ala 
        35                  40                  45              


Ser Ser Asp His Gln Gly Asn Asp Lys Thr Tyr His Cys Lys Gly Leu 
    50                  55                  60                  


Leu Pro Pro Pro Glu Lys Leu Thr Ala Glu Val Leu Gly Ile Ile Cys 
65                  70                  75                  80  


Ile Val Leu Met Ala Thr Val Leu Lys Thr Ile Val Leu Ile Pro Cys 
                85                  90                  95      


Ile Gly Val Leu Glu Gln Asn Asn Phe Ser Leu Asn Arg Arg Met Gln 
            100                 105                 110         


Lys Ala Arg His Cys Gly His Cys Pro Glu Glu Trp Ile Thr Tyr Ser 
        115                 120                 125             


Asn Ser Cys Tyr Tyr Ile Gly Lys Glu Arg Arg Thr Trp Glu Glu Arg 
    130                 135                 140                 


Val Cys Trp Pro Val Leu Arg Arg Thr Leu Ile Cys Phe Leu 
145                 150                 155             


<210>  3821
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  3821

Met Gln Pro Ala Lys Glu Val Thr Lys Ala Ser Asp Gly Ser Leu Leu 
1               5                   10                  15      


Gly Asp Leu Gly His Thr Pro Leu Ser Lys Lys Glu Gly Ile Lys Trp 
            20                  25                  30          


Gln Arg Pro Arg Leu Ser Arg Gln Ala Leu Met Arg Cys Cys Leu Val 
        35                  40                  45              


Lys Trp Ile Leu Ser Ser Thr Ala Pro Gln Gly Ser Asp Ser Ser Asp 
    50                  55                  60                  


Ser Glu Leu Glu Leu Ser Thr Val Arg His Gln Pro Glu Gly Leu Asp 
65                  70                  75                  80  


Gln Leu Gln Ala Gln Thr Lys Phe Thr Lys Lys Glu Leu Gln Ser Leu 
                85                  90                  95      


Tyr Arg Gly Phe Lys Asn Glu Cys Pro Thr Gly Leu Val Asp Glu Asp 
            100                 105                 110         


Thr Phe Lys Leu Ile Tyr Ala Gln Phe Phe Pro Gln Gly Asp Ala Thr 
        115                 120                 125             


Thr Tyr Ala His Phe Leu Phe Asn Ala Phe Asp Ala Asp Gly Asn Gly 
    130                 135                 140                 


Ala Ile His Phe Glu Asp Phe Val Val Gly Leu Ser Ile Leu Leu Arg 
145                 150                 155                 160 


Gly Thr Val His Glu Lys Leu Lys Trp Ala Phe Asn Leu Tyr Asp Ile 
                165                 170                 175     


Asn Lys Asp Gly Tyr Ile Thr Lys Glu Glu Met Leu Ala Ile Met Lys 
            180                 185                 190         


Ser Ile Tyr Asp Met Met Gly Arg His Thr Tyr Pro Ile Leu Arg Glu 
        195                 200                 205             


Asp Ala Pro Ala Glu His Val Glu Arg Phe Phe Glu Lys Met Asp Arg 
    210                 215                 220                 


Asn Gln Asp Gly Val Val Thr Ile Glu Glu Phe Leu Glu Ala Cys Gln 
225                 230                 235                 240 


Lys Asp Glu Asn Ile Met Ser Ser Met Gln Leu Phe Glu Asn Val Ile 
                245                 250                 255     


<210>  3822
<211>  859
<212>  PRT
<213>  Homo sapiens

<400>  3822

Met Ala Cys Arg Trp Ser Thr Lys Glu Ser Pro Arg Trp Arg Ser Ala 
1               5                   10                  15      


Leu Leu Leu Leu Phe Leu Ala Gly Val Tyr Gly Asn Gly Ala Leu Ala 
            20                  25                  30          


Glu His Ser Glu Asn Val His Ile Ser Gly Val Ser Thr Ala Cys Gly 
        35                  40                  45              


Glu Thr Pro Glu Gln Ile Arg Ala Pro Ser Gly Ile Ile Thr Ser Pro 
    50                  55                  60                  


Gly Trp Pro Ser Glu Tyr Pro Ala Lys Ile Asn Cys Ser Trp Phe Ile 
65                  70                  75                  80  


Arg Ala Asn Pro Gly Glu Ile Ile Thr Ile Ser Phe Gln Asp Phe Asp 
                85                  90                  95      


Ile Gln Gly Ser Arg Arg Cys Asn Leu Asp Trp Leu Thr Ile Glu Thr 
            100                 105                 110         


Tyr Lys Asn Ile Glu Ser Tyr Arg Ala Cys Gly Ser Thr Ile Pro Pro 
        115                 120                 125             


Pro Tyr Ile Ser Ser Gln Asp His Ile Trp Ile Arg Phe His Ser Asp 
    130                 135                 140                 


Asp Asn Ile Ser Arg Lys Gly Phe Arg Leu Ala Tyr Phe Ser Gly Lys 
145                 150                 155                 160 


Ser Glu Glu Pro Asn Cys Ala Cys Asp Gln Phe Arg Cys Gly Asn Gly 
                165                 170                 175     


Lys Cys Ile Pro Glu Ala Trp Lys Cys Asn Asn Met Asp Glu Cys Gly 
            180                 185                 190         


Asp Ser Ser Asp Glu Glu Ile Cys Ala Lys Glu Ala Asn Pro Pro Thr 
        195                 200                 205             


Ala Ala Ala Phe Gln Pro Cys Ala Tyr Asn Gln Phe Gln Cys Leu Ser 
    210                 215                 220                 


Arg Phe Thr Lys Val Tyr Thr Cys Leu Pro Glu Ser Leu Lys Cys Asp 
225                 230                 235                 240 


Gly Asn Ile Asp Cys Leu Asp Leu Gly Asp Glu Ile Asp Cys Asp Val 
                245                 250                 255     


Pro Thr Cys Gly Gln Trp Leu Lys Tyr Phe Tyr Gly Thr Phe Asn Ser 
            260                 265                 270         


Pro Asn Tyr Pro Asp Phe Tyr Pro Pro Gly Ser Asn Cys Thr Trp Leu 
        275                 280                 285             


Ile Asp Thr Gly Asp His Arg Lys Val Ile Leu Arg Phe Thr Asp Phe 
    290                 295                 300                 


Lys Leu Asp Gly Thr Gly Tyr Gly Asp Tyr Val Lys Ile Tyr Asp Gly 
305                 310                 315                 320 


Leu Glu Glu Asn Pro His Lys Leu Leu Arg Val Leu Thr Ala Phe Asp 
                325                 330                 335     


Ser His Ala Pro Leu Thr Val Val Ser Ser Ser Gly Gln Ile Arg Val 
            340                 345                 350         


His Phe Cys Ala Asp Lys Val Asn Ala Ala Arg Gly Phe Asn Ala Thr 
        355                 360                 365             


Tyr Gln Val Asp Gly Phe Cys Leu Pro Trp Glu Ile Pro Cys Gly Gly 
    370                 375                 380                 


Asn Trp Gly Cys Tyr Thr Glu Gln Gln Arg Cys Asp Gly Tyr Trp His 
385                 390                 395                 400 


Cys Pro Asn Gly Arg Asp Glu Thr Asn Cys Thr Met Cys Gln Lys Glu 
                405                 410                 415     


Glu Phe Pro Cys Ser Arg Asn Gly Val Cys Tyr Pro Arg Ser Asp Arg 
            420                 425                 430         


Cys Asn Tyr Gln Asn His Cys Pro Asn Gly Ser Asp Glu Lys Asn Cys 
        435                 440                 445             


Phe Phe Cys Gln Pro Gly Asn Phe His Cys Lys Asn Asn Arg Cys Val 
    450                 455                 460                 


Phe Glu Ser Trp Val Cys Asp Ser Gln Asp Asp Cys Gly Asp Gly Ser 
465                 470                 475                 480 


Asp Glu Glu Asn Cys Pro Val Ile Val Pro Thr Arg Val Ile Thr Ala 
                485                 490                 495     


Ala Val Ile Gly Ser Leu Ile Cys Gly Leu Leu Leu Val Ile Ala Leu 
            500                 505                 510         


Gly Cys Thr Cys Lys Leu Tyr Ser Leu Arg Met Phe Glu Arg Arg Ser 
        515                 520                 525             


Phe Glu Thr Gln Leu Ser Arg Val Glu Ala Glu Leu Leu Arg Arg Glu 
    530                 535                 540                 


Ala Pro Pro Ser Tyr Gly Gln Leu Ile Ala Gln Gly Leu Ile Pro Pro 
545                 550                 555                 560 


Val Glu Asp Phe Pro Val Cys Ser Pro Asn Gln Ala Ser Val Leu Glu 
                565                 570                 575     


Asn Leu Arg Leu Ala Val Arg Ser Gln Leu Gly Phe Thr Ser Val Arg 
            580                 585                 590         


Leu Pro Met Ala Gly Arg Ser Ser Asn Ile Trp Asn Arg Ile Phe Asn 
        595                 600                 605             


Phe Ala Arg Ser Arg His Ser Gly Ser Leu Ala Leu Val Ser Ala Asp 
    610                 615                 620                 


Gly Asp Glu Val Val Pro Ser Gln Ser Thr Ser Arg Glu Pro Glu Arg 
625                 630                 635                 640 


Asn His Thr His Arg Ser Leu Phe Ser Val Glu Ser Asp Asp Thr Asp 
                645                 650                 655     


Thr Glu Asn Glu Arg Arg Asp Met Ala Gly Ala Ser Gly Gly Val Ala 
            660                 665                 670         


Ala Pro Leu Pro Gln Lys Val Pro Pro Thr Thr Ala Val Glu Ala Thr 
        675                 680                 685             


Val Gly Ala Cys Ala Ser Ser Ser Thr Gln Ser Thr Arg Gly Gly His 
    690                 695                 700                 


Ala Asp Asn Gly Arg Asp Val Thr Ser Val Glu Pro Pro Ser Val Ser 
705                 710                 715                 720 


Pro Ala Arg His Gln Leu Thr Ser Ala Leu Ser Arg Met Thr Gln Gly 
                725                 730                 735     


Leu Arg Trp Val Arg Phe Thr Leu Gly Arg Ser Ser Ser Leu Ser Gln 
            740                 745                 750         


Asn Gln Ser Pro Leu Arg Gln Leu Asp Asn Gly Val Ser Gly Arg Glu 
        755                 760                 765             


Asp Asp Asp Asp Val Glu Met Leu Ile Pro Ile Ser Asp Gly Ser Ser 
    770                 775                 780                 


Asp Phe Asp Val Asn Asp Cys Ser Arg Pro Leu Leu Asp Leu Ala Ser 
785                 790                 795                 800 


Asp Gln Gly Gln Gly Leu Arg Gln Pro Tyr Asn Ala Thr Asn Pro Gly 
                805                 810                 815     


Val Arg Pro Ser Asn Arg Asp Gly Pro Cys Glu Arg Cys Gly Ile Val 
            820                 825                 830         


His Thr Ala Gln Ile Pro Asp Thr Cys Leu Glu Val Thr Leu Lys Asn 
        835                 840                 845             


Glu Thr Ser Asp Asp Glu Ala Leu Leu Leu Cys 
    850                 855                 


<210>  3823
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  3823

Met Gly Arg Pro Leu Leu Leu Pro Leu Leu Pro Leu Leu Leu Pro Pro 
1               5                   10                  15      


Ala Phe Leu Gln Pro Ser Gly Ser Thr Gly Ser Gly Pro Ser Tyr Leu 
            20                  25                  30          


Tyr Gly Val Thr Gln Pro Lys His Leu Ser Ala Ser Met Gly Gly Ser 
        35                  40                  45              


Val Glu Ile Pro Phe Ser Phe Tyr Tyr Pro Trp Glu Leu Ala Thr Ala 
    50                  55                  60                  


Pro Asp Val Arg Ile Ser Trp Arg Arg Gly His Phe His Arg Gln Ser 
65                  70                  75                  80  


Phe Tyr Ser Thr Arg Pro Pro Ser Ile His Lys Asp Tyr Val Asn Arg 
                85                  90                  95      


Leu Phe Leu Asn Trp Thr Glu Gly Gln Lys Ser Gly Phe Leu Arg Ile 
            100                 105                 110         


Ser Asn Leu Gln Lys Gln Asp Gln Ser Val Tyr Phe Cys Arg Val Glu 
        115                 120                 125             


Leu Asp Thr Arg Ser Ser Gly Arg Gln Gln Trp Gln Ser Ile Glu Gly 
    130                 135                 140                 


Thr Lys Leu Ser Ile Thr Gln Ala Val Thr Thr Thr Thr Gln Arg Pro 
145                 150                 155                 160 


Ser Ser Met Thr Thr Thr Trp Arg Leu Ser Ser Thr Thr Thr Thr Thr 
                165                 170                 175     


Gly Leu Arg Val Thr Gln Gly Lys Arg Arg Ser Asp Ser Trp His Ile 
            180                 185                 190         


Ser Leu Glu Thr Ala Val Gly Val Ala Val Ala Val Thr Val Leu Gly 
        195                 200                 205             


Ile Met Ile Leu Gly Leu Ile Cys Leu Leu Arg Trp Arg Arg Arg Lys 
    210                 215                 220                 


Gly Gln Gln Arg Thr Lys Ala Thr Thr Pro Ala Arg Glu Pro Phe Gln 
225                 230                 235                 240 


Asn Thr Glu Glu Pro Tyr Glu Asn Ile Arg Asn Glu Gly Gln Asn Thr 
                245                 250                 255     


Asp Pro Lys Leu Asn Pro Lys Asp Asp Gly Ile Val Tyr Ala Ser Leu 
            260                 265                 270         


Ala Leu Ser Ser Ser Thr Ser Pro Arg Ala Pro Pro Ser His Arg Pro 
        275                 280                 285             


Leu Lys Ser Pro Gln Asn Glu Thr Leu Tyr Ser Val Leu Lys Ala 
    290                 295                 300             


<210>  3824
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  3824

Met Ala Cys Ser Arg Pro Pro Ser Gln Cys Glu Pro Thr Ser Leu Pro 
1               5                   10                  15      


Pro Gly Pro Pro Ala Gly Arg Arg His Leu Pro Leu Ser Arg Arg Arg 
            20                  25                  30          


Arg Glu Met Ser Ser Asn Lys Glu Gln Arg Ser Ala Val Phe Val Ile 
        35                  40                  45              


Leu Phe Ala Leu Ile Thr Ile Leu Ile Leu Tyr Ser Ser Asn Ser Ala 
    50                  55                  60                  


Asn Glu Val Phe His Tyr Gly Ser Leu Arg Gly Arg Ser Arg Arg Pro 
65                  70                  75                  80  


Val Asn Leu Lys Lys Trp Ser Ile Thr Asp Gly Tyr Val Pro Ile Leu 
                85                  90                  95      


Gly Asn Lys Thr Leu Pro Ser Arg Cys His Gln Cys Val Ile Val Ser 
            100                 105                 110         


Ser Ser Ser His Leu Leu Gly Thr Lys Leu Gly Pro Glu Ile Glu Arg 
        115                 120                 125             


Ala Glu Cys Thr Ile Arg Met Asn Asp Ala Pro Thr Thr Gly Tyr Ser 
    130                 135                 140                 


Ala Asp Val Gly Asn Lys Thr Thr Tyr Arg Val Val Ala His Ser Ser 
145                 150                 155                 160 


Val Phe Arg Val Leu Arg Arg Pro Gln Glu Phe Val Asn Arg Thr Pro 
                165                 170                 175     


Glu Thr Val Phe Ile Phe Trp Gly Pro Pro Ser Lys Met Gln Lys Pro 
            180                 185                 190         


Gln Gly Ser Leu Val Arg Val Ile Gln Arg Ala Gly Leu Val Phe Pro 
        195                 200                 205             


Asn Met Glu Ala Tyr Ala Val Ser Pro Gly Arg Met Arg Gln Phe Asp 
    210                 215                 220                 


Asp Leu Phe Arg Gly Glu Thr Gly Lys Asp Arg Glu Lys Ser His Ser 
225                 230                 235                 240 


Trp Leu Ser Thr Gly Trp Phe Thr Met Val Ile Ala Val Glu Leu Cys 
                245                 250                 255     


Asp His Val His Val Tyr Gly Met Val Pro Pro Asn Tyr Cys Ser Gln 
            260                 265                 270         


Arg Pro Arg Leu Gln Arg Met Pro Tyr His Tyr Tyr Glu Pro Lys Gly 
        275                 280                 285             


Pro Asp Glu Cys Val Thr Tyr Ile Gln Asn Glu His Ser Arg Lys Gly 
    290                 295                 300                 


Asn His His Arg Phe Ile Thr Glu Lys Arg Val Phe Ser Ser Trp Ala 
305                 310                 315                 320 


Gln Leu Tyr Gly Ile Thr Phe Ser His Pro Ser Trp Thr 
                325                 330             


<210>  3825
<211>  823
<212>  PRT
<213>  Homo sapiens

<400>  3825

Met Gly Gly Arg Val Phe Leu Val Phe Leu Ala Phe Cys Val Trp Leu 
1               5                   10                  15      


Thr Leu Pro Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp 
            20                  25                  30          


Cys Pro Gln Asp Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn 
        35                  40                  45              


Pro Gly Phe Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Met Glu Thr 
    50                  55                  60                  


Cys Asp Asp Ile Asn Glu Cys Ala Thr Leu Ser Lys Val Ser Cys Gly 
65                  70                  75                  80  


Lys Phe Ser Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys 
                85                  90                  95      


Ser Pro Gly Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu 
            100                 105                 110         


Ser Glu Asn Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg 
        115                 120                 125             


Leu Cys Lys Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr 
    130                 135                 140                 


Cys Gln Cys Leu Pro Gly Phe Lys Leu Lys Pro Glu Asp Pro Lys Leu 
145                 150                 155                 160 


Cys Thr Asp Val Asn Glu Cys Thr Ser Gly Gln Asn Pro Cys His Ser 
                165                 170                 175     


Ser Thr His Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg 
            180                 185                 190         


Pro Gly Trp Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Thr 
        195                 200                 205             


Val Cys Glu Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp 
    210                 215                 220                 


Ser Ser Thr Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys 
225                 230                 235                 240 


Arg Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp 
                245                 250                 255     


Thr Val Cys Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly 
            260                 265                 270         


Val His Ser Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu 
        275                 280                 285             


Gly Arg Asp Tyr Lys Pro Gly Leu Ala Asn Asn Thr Ile Gln Ser Ile 
    290                 295                 300                 


Leu Gln Ala Leu Asp Glu Leu Leu Glu Ala Pro Gly Asp Leu Glu Thr 
305                 310                 315                 320 


Leu Pro Arg Leu Gln Gln His Cys Val Ala Ser His Leu Leu Asp Gly 
                325                 330                 335     


Leu Glu Asp Val Leu Arg Gly Leu Ser Lys Asn Leu Ser Asn Gly Leu 
            340                 345                 350         


Leu Asn Phe Ser Tyr Pro Ala Gly Thr Glu Leu Ser Leu Glu Val Gln 
        355                 360                 365             


Lys Gln Val Asp Arg Ser Val Thr Leu Arg Gln Asn Gln Ala Val Met 
    370                 375                 380                 


Gln Leu Asp Trp Asn Gln Ala Gln Lys Ser Gly Asp Pro Gly Pro Ser 
385                 390                 395                 400 


Val Val Gly Leu Val Ser Ile Pro Gly Met Gly Lys Leu Leu Ala Glu 
                405                 410                 415     


Ala Pro Leu Val Leu Glu Pro Glu Lys Gln Met Leu Leu His Glu Thr 
            420                 425                 430         


His Gln Gly Leu Leu Gln Asp Gly Ser Pro Ile Leu Leu Ser Asp Val 
        435                 440                 445             


Ile Ser Ala Phe Leu Ser Asn Asn Asp Thr Gln Asn Leu Ser Ser Pro 
    450                 455                 460                 


Val Thr Phe Thr Phe Ser His Arg Ser Val Ile Pro Arg Gln Lys Val 
465                 470                 475                 480 


Leu Cys Val Phe Trp Glu His Gly Gln Asn Gly Cys Gly His Trp Ala 
                485                 490                 495     


Thr Thr Gly Cys Ser Thr Ile Gly Thr Arg Asp Thr Ser Thr Ile Cys 
            500                 505                 510         


Arg Cys Thr His Leu Ser Ser Phe Ala Val Leu Met Ala His Tyr Asp 
        515                 520                 525             


Val Gln Glu Glu Asp Pro Val Leu Thr Val Ile Thr Tyr Met Gly Leu 
    530                 535                 540                 


Ser Val Ser Leu Leu Cys Leu Leu Leu Ala Ala Leu Thr Phe Leu Leu 
545                 550                 555                 560 


Cys Lys Ala Ile Gln Asn Thr Ser Thr Ser Leu His Leu Gln Leu Ser 
                565                 570                 575     


Leu Cys Leu Phe Leu Ala His Leu Leu Phe Leu Val Ala Ile Asp Gln 
            580                 585                 590         


Thr Gly His Lys Val Leu Cys Ser Ile Ile Ala Gly Thr Leu His Tyr 
        595                 600                 605             


Leu Tyr Leu Ala Thr Leu Thr Trp Met Leu Leu Glu Ala Leu Tyr Leu 
    610                 615                 620                 


Phe Leu Thr Ala Arg Asn Leu Thr Val Val Asn Tyr Ser Ser Ile Asn 
625                 630                 635                 640 


Arg Phe Met Lys Lys Leu Met Phe Pro Val Gly Tyr Gly Val Pro Ala 
                645                 650                 655     


Val Thr Val Ala Ile Ser Ala Ala Ser Arg Pro His Leu Tyr Gly Thr 
            660                 665                 670         


Pro Ser Arg Cys Trp Leu Gln Pro Glu Lys Gly Phe Ile Trp Gly Phe 
        675                 680                 685             


Leu Gly Pro Val Cys Ala Ile Phe Ser Val Asn Leu Val Leu Phe Leu 
    690                 695                 700                 


Val Thr Leu Trp Ile Leu Lys Asn Arg Leu Ser Ser Leu Asn Ser Glu 
705                 710                 715                 720 


Val Ser Thr Leu Arg Asn Thr Arg Met Leu Ala Phe Lys Ala Thr Ala 
                725                 730                 735     


Gln Leu Phe Ile Leu Gly Cys Thr Trp Cys Leu Gly Ile Leu Gln Val 
            740                 745                 750         


Gly Pro Ala Ala Arg Val Met Ala Tyr Leu Phe Thr Ile Ile Asn Ser 
        755                 760                 765             


Leu Gln Gly Val Phe Ile Phe Leu Val Tyr Cys Leu Leu Ser Gln Gln 
    770                 775                 780                 


Val Arg Glu Gln Tyr Gly Lys Trp Ser Lys Gly Ile Arg Lys Leu Lys 
785                 790                 795                 800 


Thr Glu Ser Glu Met His Thr Leu Ser Ser Ser Ala Lys Ala Asp Thr 
                805                 810                 815     


Ser Lys Pro Ser Thr Val Asn 
            820             


<210>  3826
<211>  2061
<212>  PRT
<213>  Homo sapiens

<400>  3826

Met Leu Arg Val Ile Val Glu Ser Ala Ser Asn Ile Pro Lys Thr Lys 
1               5                   10                  15      


Phe Gly Lys Pro Asp Pro Ile Val Ser Val Ile Phe Lys Asp Glu Lys 
            20                  25                  30          


Lys Lys Thr Lys Lys Val Asp Asn Glu Leu Asn Pro Val Trp Asn Glu 
        35                  40                  45              


Ile Leu Glu Phe Asp Leu Arg Gly Ile Pro Leu Asp Phe Ser Ser Ser 
    50                  55                  60                  


Leu Gly Ile Ile Val Lys Asp Phe Glu Thr Ile Gly Gln Asn Lys Leu 
65                  70                  75                  80  


Ile Gly Thr Ala Thr Val Ala Leu Lys Asp Leu Thr Gly Asp Gln Ser 
                85                  90                  95      


Arg Ser Leu Pro Tyr Lys Leu Ile Ser Leu Leu Asn Glu Lys Gly Gln 
            100                 105                 110         


Asp Thr Gly Ala Thr Ile Asp Leu Val Ile Gly Tyr Asp Pro Pro Ser 
        115                 120                 125             


Ala Pro His Pro Asn Asp Leu Ser Gly Pro Ser Val Pro Gly Met Gly 
    130                 135                 140                 


Gly Asp Gly Glu Glu Asp Glu Gly Asp Glu Asp Arg Leu Asp Asn Ala 
145                 150                 155                 160 


Val Arg Gly Pro Gly Pro Lys Gly Pro Val Gly Thr Val Ser Glu Ala 
                165                 170                 175     


Gln Leu Ala Arg Arg Leu Thr Lys Val Lys Asn Ser Arg Arg Met Leu 
            180                 185                 190         


Ser Asn Lys Pro Gln Asp Phe Gln Ile Arg Val Arg Val Ile Glu Gly 
        195                 200                 205             


Arg Gln Leu Ser Gly Asn Asn Ile Arg Pro Val Val Lys Val His Val 
    210                 215                 220                 


Cys Gly Gln Thr His Arg Thr Arg Ile Lys Arg Gly Asn Asn Pro Phe 
225                 230                 235                 240 


Phe Asp Glu Leu Phe Phe Tyr Asn Val Asn Met Thr Pro Ser Glu Leu 
                245                 250                 255     


Met Asp Glu Ile Ile Ser Ile Arg Val Tyr Asn Ser His Ser Leu Arg 
            260                 265                 270         


Ala Asp Cys Leu Met Gly Glu Phe Lys Ile Asp Val Gly Phe Val Tyr 
        275                 280                 285             


Asp Glu Pro Gly His Ala Val Met Arg Lys Trp Leu Leu Leu Asn Asp 
    290                 295                 300                 


Pro Glu Asp Thr Ser Ser Gly Ser Lys Gly Tyr Met Lys Val Ser Met 
305                 310                 315                 320 


Phe Val Leu Gly Thr Gly Asp Glu Pro Pro Pro Glu Arg Arg Asp Arg 
                325                 330                 335     


Asp Asn Asp Ser Asp Asp Val Glu Ser Asn Leu Leu Leu Pro Ala Gly 
            340                 345                 350         


Ile Ala Leu Arg Trp Val Thr Phe Leu Leu Lys Ile Tyr Arg Ala Glu 
        355                 360                 365             


Asp Ile Pro Gln Met Asp Asp Ala Phe Ser Gln Thr Val Lys Glu Ile 
    370                 375                 380                 


Phe Gly Gly Asn Ala Asp Lys Lys Asn Leu Val Asp Pro Phe Val Glu 
385                 390                 395                 400 


Val Ser Phe Ala Gly Lys Lys Val Cys Thr Asn Ile Ile Glu Lys Asn 
                405                 410                 415     


Ala Asn Pro Glu Trp Asn Gln Val Val Asn Leu Gln Ile Lys Phe Pro 
            420                 425                 430         


Ser Val Cys Glu Lys Ile Lys Leu Thr Ile Tyr Asp Trp Asp Arg Leu 
        435                 440                 445             


Thr Lys Asn Asp Val Val Gly Thr Thr Tyr Leu His Leu Ser Lys Ile 
    450                 455                 460                 


Ala Ala Ser Gly Gly Glu Val Glu Asp Phe Ser Ser Ser Gly Thr Gly 
465                 470                 475                 480 


Ala Ala Ser Tyr Thr Val Asn Thr Gly Glu Thr Glu Val Gly Phe Val 
                485                 490                 495     


Pro Thr Phe Gly Pro Cys Tyr Leu Asn Leu Tyr Gly Ser Pro Arg Glu 
            500                 505                 510         


Tyr Thr Gly Phe Pro Asp Pro Tyr Asp Glu Leu Asn Thr Gly Lys Gly 
        515                 520                 525             


Glu Gly Val Ala Tyr Arg Gly Arg Ile Leu Val Glu Leu Ala Thr Phe 
    530                 535                 540                 


Leu Glu Lys Thr Pro Pro Asp Lys Lys Leu Glu Pro Ile Ser Asn Asp 
545                 550                 555                 560 


Asp Leu Leu Val Val Glu Lys Tyr Gln Arg Arg Arg Lys Tyr Ser Leu 
                565                 570                 575     


Ser Ala Val Phe His Ser Ala Thr Met Leu Gln Asp Val Gly Glu Ala 
            580                 585                 590         


Ile Gln Phe Glu Val Ser Ile Gly Asn Tyr Gly Asn Lys Phe Asp Thr 
        595                 600                 605             


Thr Cys Lys Pro Leu Ala Ser Thr Thr Gln Tyr Ser Arg Ala Val Phe 
    610                 615                 620                 


Asp Gly Asn Tyr Tyr Tyr Tyr Leu Pro Trp Ala His Thr Lys Pro Val 
625                 630                 635                 640 


Val Thr Leu Thr Ser Tyr Trp Glu Asp Ile Ser His Arg Leu Asp Ala 
                645                 650                 655     


Val Asn Thr Leu Leu Ala Met Ala Glu Arg Leu Gln Thr Asn Ile Glu 
            660                 665                 670         


Ala Leu Lys Ser Gly Ile Gln Gly Lys Ile Pro Ala Asn Gln Leu Ala 
        675                 680                 685             


Glu Leu Trp Leu Lys Leu Ile Asp Glu Val Ile Glu Asp Thr Arg Tyr 
    690                 695                 700                 


Thr Leu Pro Leu Thr Glu Gly Lys Ala Asn Val Thr Val Leu Asp Thr 
705                 710                 715                 720 


Gln Ile Arg Lys Leu Arg Ser Arg Ser Leu Ser Gln Ile His Glu Ala 
                725                 730                 735     


Ala Val Arg Met Arg Ser Glu Ala Thr Asp Val Lys Ser Thr Leu Ala 
            740                 745                 750         


Glu Ile Glu Asp Trp Leu Asp Lys Leu Met Gln Leu Thr Glu Glu Pro 
        755                 760                 765             


Gln Asn Ser Met Pro Asp Ile Ile Ile Trp Met Ile Arg Gly Glu Lys 
    770                 775                 780                 


Arg Leu Ala Tyr Ala Arg Ile Pro Ala His Gln Val Leu Tyr Ser Thr 
785                 790                 795                 800 


Ser Gly Glu Asn Ala Ser Gly Lys Tyr Cys Gly Lys Thr Gln Thr Ile 
                805                 810                 815     


Phe Leu Lys Tyr Pro Gln Glu Lys Asn Asn Gly Pro Lys Val Pro Val 
            820                 825                 830         


Glu Leu Arg Val Asn Ile Trp Leu Gly Leu Ser Ala Val Glu Lys Lys 
        835                 840                 845             


Phe Asn Ser Phe Ala Glu Gly Thr Phe Thr Val Phe Ala Glu Met Tyr 
    850                 855                 860                 


Glu Asn Gln Ala Leu Met Phe Gly Lys Trp Gly Thr Ser Gly Leu Val 
865                 870                 875                 880 


Gly Arg His Lys Phe Ser Asp Val Thr Gly Lys Ile Lys Leu Lys Arg 
                885                 890                 895     


Glu Phe Phe Leu Pro Pro Lys Gly Trp Glu Trp Glu Gly Glu Trp Ile 
            900                 905                 910         


Val Asp Pro Glu Arg Ser Leu Leu Thr Glu Ala Asp Ala Gly His Thr 
        915                 920                 925             


Glu Phe Thr Asp Glu Val Tyr Gln Asn Glu Ser Arg Tyr Pro Gly Gly 
    930                 935                 940                 


Asp Trp Lys Pro Ala Glu Asp Thr Tyr Thr Asp Ala Asn Gly Asp Lys 
945                 950                 955                 960 


Ala Ala Ser Pro Ser Glu Leu Thr Cys Pro Pro Gly Trp Glu Trp Glu 
                965                 970                 975     


Asp Asp Ala Trp Ser Tyr Asp Ile Asn Arg Ala Val Asp Glu Lys Gly 
            980                 985                 990         


Trp Glu Tyr Gly Ile Thr Ile Pro  Pro Asp His Lys Pro  Lys Ser Trp 
        995                 1000                 1005             


Val Ala  Ala Glu Lys Met Tyr  His Thr His Arg Arg  Arg Arg Leu 
    1010                 1015                 1020             


Val Arg  Lys Arg Lys Lys Asp  Leu Thr Gln Thr Ala  Ser Ser Thr 
    1025                 1030                 1035             


Ala Arg  Ala Met Glu Glu Leu  Gln Asp Gln Glu Gly  Trp Glu Tyr 
    1040                 1045                 1050             


Ala Ser  Leu Ile Gly Trp Lys  Phe His Trp Lys Gln  Arg Ser Ser 
    1055                 1060                 1065             


Asp Thr  Phe Arg Arg Arg Arg  Trp Arg Arg Lys Met  Ala Pro Ser 
    1070                 1075                 1080             


Glu Thr  His Gly Ala Ala Ala  Ile Phe Lys Leu Glu  Gly Ala Leu 
    1085                 1090                 1095             


Gly Ala  Asp Thr Thr Glu Asp  Gly Asp Glu Lys Ser  Leu Glu Lys 
    1100                 1105                 1110             


Gln Lys  His Ser Ala Thr Thr  Val Phe Gly Ala Asn  Thr Pro Ile 
    1115                 1120                 1125             


Val Ser  Cys Asn Phe Asp Arg  Val Tyr Ile Tyr His  Leu Arg Cys 
    1130                 1135                 1140             


Tyr Val  Tyr Gln Ala Arg Asn  Leu Leu Ala Leu Asp  Lys Asp Ser 
    1145                 1150                 1155             


Phe Ser  Asp Pro Tyr Ala His  Ile Cys Phe Leu His  Arg Ser Lys 
    1160                 1165                 1170             


Thr Thr  Glu Ile Ile His Ser  Thr Leu Asn Pro Thr  Trp Asp Gln 
    1175                 1180                 1185             


Thr Ile  Ile Phe Asp Glu Val  Glu Ile Tyr Gly Glu  Pro Gln Thr 
    1190                 1195                 1200             


Val Leu  Gln Asn Pro Pro Lys  Val Ile Met Glu Leu  Phe Asp Asn 
    1205                 1210                 1215             


Asp Gln  Val Gly Lys Asp Glu  Phe Leu Gly Arg Ser  Ile Phe Ser 
    1220                 1225                 1230             


Pro Val  Val Lys Leu Asn Ser  Glu Met Asp Ile Thr  Pro Lys Leu 
    1235                 1240                 1245             


Leu Trp  His Pro Val Met Asn  Gly Asp Lys Ala Cys  Gly Asp Val 
    1250                 1255                 1260             


Leu Val  Thr Ala Glu Leu Ile  Leu Arg Gly Lys Asp  Gly Ser Asn 
    1265                 1270                 1275             


Leu Pro  Ile Leu Pro Pro Gln  Arg Ala Pro Asn Leu  Tyr Met Val 
    1280                 1285                 1290             


Pro Gln  Gly Ile Arg Pro Val  Val Gln Leu Thr Ala  Ile Glu Ile 
    1295                 1300                 1305             


Leu Ala  Trp Gly Leu Arg Asn  Met Lys Asn Phe Gln  Met Ala Ser 
    1310                 1315                 1320             


Ile Thr  Ser Pro Ser Leu Val  Val Glu Cys Gly Gly  Glu Arg Val 
    1325                 1330                 1335             


Glu Ser  Val Val Ile Lys Asn  Leu Lys Lys Thr Pro  Asn Phe Pro 
    1340                 1345                 1350             


Ser Ser  Val Leu Phe Met Lys  Val Phe Leu Pro Lys  Glu Glu Leu 
    1355                 1360                 1365             


Tyr Met  Pro Pro Leu Val Ile  Lys Val Ile Asp His  Arg Gln Phe 
    1370                 1375                 1380             


Gly Arg  Lys Pro Val Val Gly  Gln Cys Thr Ile Glu  Arg Leu Asp 
    1385                 1390                 1395             


Arg Phe  Arg Cys Asp Pro Tyr  Ala Gly Lys Glu Asp  Ile Val Pro 
    1400                 1405                 1410             


Gln Leu  Lys Ala Ser Leu Leu  Ser Ala Pro Pro Cys  Arg Asp Ile 
    1415                 1420                 1425             


Val Ile  Glu Met Glu Asp Thr  Lys Pro Leu Leu Ala  Ser Lys Leu 
    1430                 1435                 1440             


Thr Glu  Lys Glu Glu Glu Ile  Val Asp Trp Trp Ser  Lys Phe Tyr 
    1445                 1450                 1455             


Ala Ser  Ser Gly Glu His Glu  Lys Cys Gly Gln Tyr  Ile Gln Lys 
    1460                 1465                 1470             


Gly Tyr  Ser Lys Leu Lys Ile  Tyr Asn Cys Glu Leu  Glu Asn Val 
    1475                 1480                 1485             


Ala Glu  Phe Glu Gly Leu Thr  Asp Phe Ser Asp Thr  Phe Lys Leu 
    1490                 1495                 1500             


Tyr Arg  Gly Lys Ser Asp Glu  Asn Glu Asp Pro Ser  Val Val Gly 
    1505                 1510                 1515             


Glu Phe  Lys Gly Ser Phe Arg  Ile Tyr Pro Leu Pro  Asp Asp Pro 
    1520                 1525                 1530             


Ser Val  Pro Ala Pro Pro Arg  Gln Phe Arg Glu Leu  Pro Asp Ser 
    1535                 1540                 1545             


Val Pro  Gln Glu Cys Thr Val  Arg Ile Tyr Ile Val  Arg Gly Leu 
    1550                 1555                 1560             


Glu Leu  Gln Pro Gln Asp Asn  Asn Gly Leu Cys Asp  Pro Tyr Ile 
    1565                 1570                 1575             


Lys Ile  Thr Leu Gly Lys Lys  Val Ile Glu Asp Arg  Asp His Tyr 
    1580                 1585                 1590             


Ile Pro  Asn Thr Leu Asn Pro  Val Phe Gly Arg Met  Tyr Glu Leu 
    1595                 1600                 1605             


Ser Cys  Tyr Leu Pro Gln Glu  Lys Asp Leu Lys Ile  Ser Val Tyr 
    1610                 1615                 1620             


Asp Tyr  Asp Thr Phe Thr Arg  Asp Glu Lys Val Gly  Glu Thr Ile 
    1625                 1630                 1635             


Ile Asp  Leu Glu Asn Arg Phe  Leu Ser Arg Phe Gly  Ser His Cys 
    1640                 1645                 1650             


Gly Ile  Pro Glu Glu Tyr Cys  Val Ser Gly Val Asn  Thr Trp Arg 
    1655                 1660                 1665             


Asp Gln  Leu Arg Pro Thr Gln  Leu Leu Gln Asn Val  Ala Arg Phe 
    1670                 1675                 1680             


Lys Gly  Phe Pro Gln Pro Ile  Leu Ser Glu Asp Gly  Ser Arg Ile 
    1685                 1690                 1695             


Arg Tyr  Gly Gly Arg Asp Tyr  Ser Leu Asp Glu Phe  Glu Ala Asn 
    1700                 1705                 1710             


Lys Ile  Leu His Gln His Leu  Gly Ala Pro Glu Glu  Arg Leu Ala 
    1715                 1720                 1725             


Leu His  Ile Leu Arg Thr Gln  Gly Leu Val Pro Glu  His Val Glu 
    1730                 1735                 1740             


Thr Arg  Thr Leu His Ser Thr  Phe Gln Pro Asn Ile  Ser Gln Gly 
    1745                 1750                 1755             


Lys Leu  Gln Met Trp Val Asp  Val Phe Pro Lys Ser  Leu Gly Pro 
    1760                 1765                 1770             


Pro Gly  Pro Pro Phe Asn Ile  Thr Pro Arg Lys Ala  Lys Lys Tyr 
    1775                 1780                 1785             


Tyr Leu  Arg Val Ile Ile Trp  Asn Thr Lys Asp Val  Ile Leu Asp 
    1790                 1795                 1800             


Glu Lys  Ser Ile Thr Gly Glu  Glu Met Ser Asp Ile  Tyr Val Lys 
    1805                 1810                 1815             


Gly Trp  Ile Pro Gly Asn Glu  Glu Asn Lys Gln Lys  Thr Asp Val 
    1820                 1825                 1830             


His Tyr  Arg Ser Leu Asp Gly  Glu Gly Asn Phe Asn  Trp Arg Phe 
    1835                 1840                 1845             


Val Phe  Pro Phe Asp Tyr Leu  Pro Ala Glu Gln Leu  Cys Ile Val 
    1850                 1855                 1860             


Ala Lys  Lys Glu His Phe Trp  Ser Ile Asp Gln Thr  Glu Phe Arg 
    1865                 1870                 1875             


Ile Pro  Pro Arg Leu Ile Ile  Gln Ile Trp Asp Asn  Asp Lys Phe 
    1880                 1885                 1890             


Ser Leu  Asp Asp Tyr Leu Gly  Phe Leu Glu Leu Asp  Leu Arg His 
    1895                 1900                 1905             


Thr Ile  Ile Pro Ala Lys Ser  Pro Glu Lys Cys Arg  Leu Asp Met 
    1910                 1915                 1920             


Ile Pro  Asp Leu Lys Ala Met  Asn Pro Leu Lys Ala  Lys Thr Ala 
    1925                 1930                 1935             


Ser Leu  Phe Glu Gln Lys Ser  Met Lys Gly Trp Trp  Pro Cys Tyr 
    1940                 1945                 1950             


Ala Glu  Lys Asp Gly Ala Arg  Val Met Ala Gly Lys  Val Glu Met 
    1955                 1960                 1965             


Thr Leu  Glu Ile Leu Asn Glu  Lys Glu Ala Asp Glu  Arg Pro Ala 
    1970                 1975                 1980             


Gly Lys  Gly Arg Asp Glu Pro  Asn Met Asn Pro Lys  Leu Asp Leu 
    1985                 1990                 1995             


Pro Asn  Arg Pro Glu Thr Ser  Phe Leu Trp Phe Thr  Asn Pro Cys 
    2000                 2005                 2010             


Lys Thr  Met Lys Phe Ile Val  Trp Arg Arg Phe Lys  Trp Val Ile 
    2015                 2020                 2025             


Ile Gly  Leu Leu Phe Leu Leu  Ile Leu Leu Leu Phe  Val Ala Val 
    2030                 2035                 2040             


Leu Leu  Tyr Ser Leu Pro Asn  Tyr Leu Ser Met Lys  Ile Val Lys 
    2045                 2050                 2055             


Pro Asn  Val 
    2060     


<210>  3827
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  3827

Met Leu Asn Thr Thr Ser Val Thr Glu Phe Leu Leu Leu Gly Val Thr 
1               5                   10                  15      


Asp Ile Gln Glu Leu Gln Pro Phe Leu Phe Val Val Phe Leu Thr Ile 
            20                  25                  30          


Tyr Phe Ile Ser Val Thr Gly Asn Gly Ala Val Leu Met Ile Val Ile 
        35                  40                  45              


Ser Asp Pro Arg Leu His Ser Leu Met Tyr Phe Phe Leu Gly Asn Leu 
    50                  55                  60                  


Ser Tyr Leu Asp Ile Cys Tyr Ser Thr Val Thr Leu Pro Lys Met Leu 
65                  70                  75                  80  


Gln Asn Phe Leu Ser Thr His Lys Ala Ile Ser Phe Leu Gly Cys Ile 
                85                  90                  95      


Ser Gln Leu His Phe Phe His Ser Leu Gly Ser Thr Glu Ser Met Leu 
            100                 105                 110         


Phe Ala Val Met Ala Phe Asp Leu Ser Val Ala Ile Cys Lys Pro Leu 
        115                 120                 125             


Arg Tyr Thr Val Ile Met Asn Pro Gln Leu Cys Thr Gln Met Ala Ile 
    130                 135                 140                 


Thr Ile Trp Val Ile Gly Phe Phe His Ala Leu Leu His Ser Val Met 
145                 150                 155                 160 


Thr Ser Arg Leu Asn Phe Cys Gly Ser Asn Arg Ile His His Phe Leu 
                165                 170                 175     


Cys Asp Ile Lys Pro Leu Leu Lys Leu Ala Cys Gly Asn Thr Glu Leu 
            180                 185                 190         


Asn Gln Trp Leu Leu Ser Thr Val Thr Gly Thr Ile Ala Met Gly Pro 
        195                 200                 205             


Phe Phe Leu Thr Leu Leu Ser Tyr Phe Tyr Ile Ile Thr Tyr Leu Phe 
    210                 215                 220                 


Phe Lys Thr Arg Ser Cys Ser Met Leu Cys Lys Ala Leu Ser Thr Cys 
225                 230                 235                 240 


Ala Ser His Phe Met Val Val Ile Leu Phe Tyr Ala Pro Val Leu Phe 
                245                 250                 255     


Thr Tyr Ile His Pro Ala Leu Glu Ser Phe Met Asp Gln Asp Arg Ile 
            260                 265                 270         


Val Ala Ile Met Tyr Thr Val Val Thr Pro Val Leu Asn Pro Leu Ile 
        275                 280                 285             


Tyr Thr Leu Arg Asn Lys Glu Val Lys Gly Ala Leu Gly Arg Val Ile 
    290                 295                 300                 


Arg Arg Leu 
305         


<210>  3828
<211>  315
<212>  PRT
<213>  Homo sapiens

<400>  3828

Met Glu Ile Val Ser Thr Gly Asn Glu Thr Ile Thr Glu Phe Val Leu 
1               5                   10                  15      


Leu Gly Phe Tyr Asp Ile Pro Glu Leu His Phe Leu Phe Phe Ile Val 
            20                  25                  30          


Phe Thr Ala Val Tyr Val Phe Ile Ile Ile Gly Asn Met Leu Ile Ile 
        35                  40                  45              


Val Ala Val Val Ser Ser Gln Arg Leu His Lys Pro Met Tyr Ile Phe 
    50                  55                  60                  


Leu Ala Asn Leu Ser Phe Leu Asp Ile Leu Tyr Thr Ser Ala Val Met 
65                  70                  75                  80  


Pro Lys Met Leu Glu Gly Phe Leu Gln Glu Ala Thr Ile Ser Val Ala 
                85                  90                  95      


Gly Cys Leu Leu Gln Phe Phe Ile Phe Gly Ser Leu Ala Thr Ala Glu 
            100                 105                 110         


Cys Leu Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys 
        115                 120                 125             


Tyr Pro Leu His Tyr Pro Leu Leu Met Gly Pro Arg Arg Tyr Met Gly 
    130                 135                 140                 


Leu Val Val Thr Thr Trp Leu Ser Gly Phe Val Val Asp Gly Leu Val 
145                 150                 155                 160 


Val Ala Leu Val Ala Gln Leu Arg Phe Cys Gly Pro Asn His Ile Asp 
                165                 170                 175     


Gln Phe Tyr Cys Asp Phe Met Leu Phe Val Gly Leu Ala Cys Ser Asp 
            180                 185                 190         


Pro Arg Val Ala Gln Val Thr Thr Leu Ile Leu Ser Val Phe Cys Leu 
        195                 200                 205             


Thr Ile Pro Phe Gly Leu Ile Leu Thr Ser Tyr Ala Arg Ile Val Val 
    210                 215                 220                 


Ala Val Leu Arg Val Pro Ala Gly Ala Ser Arg Arg Arg Ala Phe Ser 
225                 230                 235                 240 


Thr Cys Ser Ser His Leu Ala Val Val Thr Thr Phe Tyr Gly Thr Leu 
                245                 250                 255     


Met Ile Phe Tyr Val Ala Pro Ser Ala Val His Ser Gln Leu Leu Ser 
            260                 265                 270         


Lys Val Phe Ser Leu Leu Tyr Thr Val Val Thr Pro Leu Phe Asn Pro 
        275                 280                 285             


Val Ile Tyr Thr Met Arg Asn Lys Glu Val His Gln Ala Leu Arg Lys 
    290                 295                 300                 


Ile Leu Cys Ile Lys Gln Thr Glu Thr Leu Asp 
305                 310                 315 


<210>  3829
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  3829

Met Pro Gly Gln Asn Tyr Arg Thr Ile Ser Glu Phe Ile Leu Ser Gly 
1               5                   10                  15      


Phe Ser Ala Phe Pro Gln Gln Leu Leu Pro Val Leu Phe Leu Leu Tyr 
            20                  25                  30          


Leu Leu Met Phe Leu Phe Thr Leu Leu Gly Asn Leu Leu Ile Met Ala 
        35                  40                  45              


Thr Val Trp Ile Glu Arg Arg Leu His Thr Pro Met Tyr Leu Phe Leu 
    50                  55                  60                  


Cys Ala Leu Ser Ile Ser Glu Ile Leu Phe Thr Val Ala Ile Thr Pro 
65                  70                  75                  80  


Arg Met Leu Ala Asp Leu Leu Phe Thr His Arg Ser Ile Thr Phe Val 
                85                  90                  95      


Ala Cys Ala Ile Gln Met Phe Phe Ser Phe Met Phe Gly Phe Thr His 
            100                 105                 110         


Ser Phe Leu Leu Met Val Met Gly Tyr Asp His Tyr Val Thr Ile Cys 
        115                 120                 125             


His Pro Leu His Tyr Asn Met Leu Met Ser Pro Arg Gly Cys Ala His 
    130                 135                 140                 


Leu Val Ala Trp Thr Trp Ala Gly Gly Ser Val Met Gly Met Met Val 
145                 150                 155                 160 


Thr Met Met Val Phe His Leu Thr Phe Cys Gly Ser Asn Val Ile His 
                165                 170                 175     


His Phe Leu Cys His Val Leu Ser Leu Leu Lys Leu Ala Cys Gly Ser 
            180                 185                 190         


Lys Thr Ser Ser Val Ile Met Gly Val Met Leu Val Cys Val Thr Ala 
        195                 200                 205             


Leu Ile Gly Cys Leu Phe Leu Ile Ile Leu Ser Phe Val Phe Ile Val 
    210                 215                 220                 


Ala Ala Ile Leu Arg Ile Pro Ser Ala Glu Gly Arg His Lys Thr Phe 
225                 230                 235                 240 


Ser Thr Cys Val Ser His Leu Thr Val Val Val Met His Tyr Ser Phe 
                245                 250                 255     


Ala Ser Leu Ile Tyr Leu Lys Pro Lys Gly Leu His Ser Met Tyr Ser 
            260                 265                 270         


Asp Ala Leu Met Ala Thr Thr Tyr Thr Val Phe Thr Pro Phe Leu Ser 
        275                 280                 285             


Pro Ile Ile Phe Ser Leu Arg Asn Lys Glu Leu Lys Asn Ala Ile Asn 
    290                 295                 300                 


Lys Asn Phe Cys Arg Arg Phe Cys Pro Leu Ser Ser 
305                 310                 315     


<210>  3830
<211>  315
<212>  PRT
<213>  Homo sapiens

<400>  3830

Met Leu Gly Leu Asn His Thr Ser Met Ser Glu Phe Ile Leu Val Gly 
1               5                   10                  15      


Phe Ser Ala Phe Pro His Leu Gln Leu Met Leu Phe Leu Leu Phe Leu 
            20                  25                  30          


Leu Met Tyr Leu Phe Thr Leu Leu Gly Asn Leu Leu Ile Met Ala Thr 
        35                  40                  45              


Val Trp Ser Glu Arg Ser Leu His Thr Pro Met Tyr Leu Phe Leu Cys 
    50                  55                  60                  


Val Leu Ser Val Ser Glu Ile Leu Tyr Thr Val Ala Ile Ile Pro Arg 
65                  70                  75                  80  


Met Leu Ala Asp Leu Leu Ser Thr Gln Arg Ser Ile Ala Phe Leu Ala 
                85                  90                  95      


Cys Ala Ser Gln Met Phe Phe Ser Phe Ser Phe Gly Phe Thr His Ser 
            100                 105                 110         


Phe Leu Leu Thr Val Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys His 
        115                 120                 125             


Pro Leu Arg Tyr Asn Val Leu Met Ser Pro Arg Gly Cys Ala Cys Leu 
    130                 135                 140                 


Val Gly Cys Ser Trp Ala Gly Gly Ser Val Met Gly Met Val Val Thr 
145                 150                 155                 160 


Ser Ala Ile Phe Gln Leu Thr Phe Cys Gly Ser His Glu Ile Gln His 
                165                 170                 175     


Phe Leu Cys His Val Pro Pro Leu Leu Lys Leu Ala Cys Gly Asn Asn 
            180                 185                 190         


Val Pro Ala Val Ala Leu Gly Val Gly Leu Val Cys Ile Met Ala Leu 
        195                 200                 205             


Leu Gly Cys Phe Leu Leu Ile Leu Leu Ser Tyr Ala Phe Ile Val Ala 
    210                 215                 220                 


Asp Ile Leu Lys Ile Pro Ser Ala Glu Gly Arg Asn Lys Ala Phe Ser 
225                 230                 235                 240 


Thr Cys Ala Ser His Leu Ile Val Val Ile Val His Tyr Gly Phe Ala 
                245                 250                 255     


Ser Val Ile Tyr Leu Lys Pro Lys Gly Pro His Ser Gln Glu Gly Asp 
            260                 265                 270         


Thr Leu Met Ala Thr Thr Tyr Ala Val Leu Thr Pro Phe Leu Ser Pro 
        275                 280                 285             


Ile Ile Phe Ser Leu Arg Asn Lys Glu Leu Lys Val Ala Met Lys Arg 
    290                 295                 300                 


Thr Phe Leu Ser Thr Leu Tyr Ser Ser Gly Thr 
305                 310                 315 


<210>  3831
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  3831

Met Gln Arg Ala Asn His Ser Thr Val Thr Gln Phe Ile Leu Val Gly 
1               5                   10                  15      


Phe Ser Val Phe Pro His Leu Gln Leu Met Leu Phe Leu Leu Phe Leu 
            20                  25                  30          


Leu Met Tyr Leu Phe Thr Leu Leu Gly Asn Leu Leu Ile Met Ala Thr 
        35                  40                  45              


Val Trp Ser Glu Arg Ser Leu His Thr Pro Met Tyr Leu Phe Leu Cys 
    50                  55                  60                  


Ala Leu Ser Val Ser Glu Ile Leu Tyr Thr Val Ala Ile Ile Pro Arg 
65                  70                  75                  80  


Met Leu Ala Asp Leu Leu Ser Thr Gln Arg Ser Ile Ala Phe Leu Ala 
                85                  90                  95      


Cys Ala Ser Gln Met Phe Phe Ser Phe Ser Phe Gly Phe Thr His Ser 
            100                 105                 110         


Phe Leu Leu Thr Val Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys His 
        115                 120                 125             


Pro Leu Arg Tyr Asn Val Leu Met Ser Pro Arg Gly Cys Ala Cys Leu 
    130                 135                 140                 


Val Gly Cys Ser Trp Ala Gly Gly Leu Val Met Gly Met Val Val Thr 
145                 150                 155                 160 


Ser Ala Ile Phe His Leu Ala Phe Cys Gly His Lys Glu Ile His His 
                165                 170                 175     


Phe Ala Cys His Val Pro Pro Leu Leu Lys Leu Ala Cys Gly Asp Asp 
            180                 185                 190         


Val Leu Val Val Ala Lys Gly Val Gly Leu Val Cys Ile Thr Ala Leu 
        195                 200                 205             


Leu Gly Cys Phe Leu Leu Ile Leu Leu Ser Tyr Ala Phe Ile Val Ala 
    210                 215                 220                 


Ala Ile Leu Lys Ile Pro Ser Ala Glu Gly Arg Asn Lys Ala Phe Ser 
225                 230                 235                 240 


Thr Cys Ala Ser His Leu Thr Val Val Val Val His Tyr Gly Phe Ala 
                245                 250                 255     


Ser Val Ile Tyr Leu Lys Pro Lys Ser Pro Gln Ser Leu Glu Gly Asp 
            260                 265                 270         


Thr Leu Met Gly Ile Thr Tyr Thr Val Leu Thr Pro Phe Leu Ser Pro 
        275                 280                 285             


Ile Ile Phe Ser Leu Arg Asn Lys Glu Leu Lys Val Ala Met Lys Lys 
    290                 295                 300                 


Thr Phe Phe Ser Lys Leu Tyr Pro Glu Lys Asn Val Met Met 
305                 310                 315             


<210>  3832
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  3832

Met Ser Ala Asn Thr Ser Met Val Thr Glu Phe Leu Leu Leu Gly Phe 
1               5                   10                  15      


Ser His Leu Ala Asp Leu Gln Gly Leu Leu Phe Ser Val Phe Leu Thr 
            20                  25                  30          


Ile Tyr Leu Leu Thr Val Ala Gly Asn Phe Leu Ile Val Val Leu Val 
        35                  40                  45              


Ser Thr Asp Ala Ala Leu Gln Ser Pro Met Tyr Phe Phe Leu Arg Thr 
    50                  55                  60                  


Leu Ser Ala Leu Glu Ile Gly Tyr Thr Ser Val Thr Val Pro Leu Leu 
65                  70                  75                  80  


Leu His His Leu Leu Thr Gly Arg Arg His Ile Ser Arg Ser Gly Cys 
                85                  90                  95      


Ala Leu Gln Met Phe Phe Phe Leu Phe Phe Gly Ala Thr Glu Cys Cys 
            100                 105                 110         


Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys Glu Pro 
        115                 120                 125             


Leu Arg Tyr Pro Leu Leu Leu Ser His Arg Val Cys Leu Gln Leu Ala 
    130                 135                 140                 


Gly Ser Ala Trp Ala Cys Gly Val Leu Val Gly Leu Gly His Thr Pro 
145                 150                 155                 160 


Phe Ile Phe Ser Leu Pro Phe Cys Gly Pro Asn Thr Ile Pro Gln Phe 
                165                 170                 175     


Phe Cys Glu Ile Gln Pro Val Leu Gln Leu Val Cys Gly Asp Thr Ser 
            180                 185                 190         


Leu Asn Glu Leu Gln Ile Ile Leu Ala Thr Ala Leu Leu Ile Leu Cys 
        195                 200                 205             


Pro Phe Gly Leu Ile Leu Gly Ser Tyr Gly Arg Ile Leu Val Thr Ile 
    210                 215                 220                 


Phe Arg Ile Pro Ser Val Ala Gly Arg Arg Lys Ala Phe Ser Thr Cys 
225                 230                 235                 240 


Ser Ser His Leu Ile Met Val Ser Leu Phe Tyr Gly Thr Ala Leu Phe 
                245                 250                 255     


Ile Tyr Ile Arg Pro Lys Ala Ser Tyr Asp Pro Ala Thr Asp Pro Leu 
            260                 265                 270         


Val Ser Leu Phe Tyr Ala Val Val Thr Pro Ile Leu Asn Pro Ile Ile 
        275                 280                 285             


Tyr Ser Leu Arg Asn Thr Glu Val Lys Ala Ala Leu Lys Arg Thr Ile 
    290                 295                 300                 


Gln Lys Thr Val Pro Met Glu Ile 
305                 310         


<210>  3833
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  3833

Met Gly Asn Trp Val Val Asn His Trp Phe Ser Val Leu Phe Leu Val 
1               5                   10                  15      


Val Trp Leu Gly Leu Asn Val Phe Leu Phe Val Asp Ala Phe Leu Lys 
            20                  25                  30          


Tyr Glu Lys Ala Asp Lys Tyr Tyr Tyr Thr Arg Lys Ile Leu Gly Ser 
        35                  40                  45              


Thr Leu Ala Cys Ala Arg Ala Ser Ala Leu Cys Leu Asn Phe Asn Ser 
    50                  55                  60                  


Thr Leu Ile Leu Leu Pro Val Cys Arg Asn Leu Leu Ser Phe Leu Arg 
65                  70                  75                  80  


Gly Thr Cys Ser Phe Cys Ser Arg Thr Leu Arg Lys Gln Leu Asp His 
                85                  90                  95      


Asn Leu Thr Phe His Lys Leu Val Ala Tyr Met Ile Cys Leu His Thr 
            100                 105                 110         


Ala Ile His Ile Ile Ala His Leu Phe Asn Phe Asp Cys Tyr Ser Arg 
        115                 120                 125             


Ser Arg Gln Ala Thr Asp Gly Ser Leu Ala Ser Ile Leu Ser Ser Leu 
    130                 135                 140                 


Ser His Asp Glu Lys Lys Gly Gly Ser Trp Leu Asn Pro Ile Gln Ser 
145                 150                 155                 160 


Arg Asn Thr Thr Val Glu Tyr Val Thr Phe Thr Ser Ile Ala Gly Leu 
                165                 170                 175     


Thr Gly Val Ile Met Thr Ile Ala Leu Ile Leu Met Val Thr Ser Ala 
            180                 185                 190         


Thr Glu Phe Ile Arg Arg Ser Tyr Phe Glu Val Phe Trp Tyr Thr His 
        195                 200                 205             


His Leu Phe Ile Phe Tyr Ile Leu Gly Leu Gly Ile His Gly Ile Gly 
    210                 215                 220                 


Gly Ile Val Arg Gly Gln Thr Glu Glu Ser Met Asn Glu Ser His Pro 
225                 230                 235                 240 


Arg Lys Cys Ala Glu Ser Phe Glu Met Trp Asp Asp Arg Asp Ser His 
                245                 250                 255     


Cys Arg Arg Pro Lys Phe Glu Gly His Pro Pro Glu Ser Trp Lys Trp 
            260                 265                 270         


Ile Leu Ala Pro Val Ile Leu Tyr Ile Cys Glu Arg Ile Leu Arg Phe 
        275                 280                 285             


Tyr Arg Ser Gln Gln Lys Val Val Ile Thr Lys Val Val Met His Pro 
    290                 295                 300                 


Ser Lys Val Leu Glu Leu Gln Met Asn Lys Arg Gly Phe Ser Met Glu 
305                 310                 315                 320 


Val Gly Gln Tyr Ile Phe Val Asn Cys Pro Ser Ile Ser Leu Leu Glu 
                325                 330                 335     


Trp His Pro Phe Thr Leu Thr Ser Ala Pro Glu Glu Asp Phe Phe Ser 
            340                 345                 350         


Ile His Ile Arg Ala Ala Gly Asp Trp Thr Glu Asn Leu Ile Arg Ala 
        355                 360                 365             


Phe Glu Gln Gln Tyr Ser Pro Ile Pro Arg Ile Glu Val Asp Gly Pro 
    370                 375                 380                 


Phe Gly Thr Ala Ser Glu Asp Val Phe Gln Tyr Glu Val Ala Val Leu 
385                 390                 395                 400 


Val Gly Ala Gly Ile Gly Val Thr Pro Phe Ala Ser Ile Leu Lys Ser 
                405                 410                 415     


Ile Trp Tyr Lys Phe Gln Cys Ala Asp His Asn Leu Lys Thr Lys Lys 
            420                 425                 430         


Val Gly His Ala Ala Leu Asn Phe Asp Lys Ala Thr Asp Ile Val Thr 
        435                 440                 445             


Gly Leu Lys Gln Lys Thr Ser Phe Gly Arg Pro Met Trp Asp Asn Glu 
    450                 455                 460                 


Phe Ser Thr Ile Ala Thr Ser His Pro Lys Ser Val Val Gly Val Phe 
465                 470                 475                 480 


Leu Cys Gly Pro Arg Thr Leu Ala Lys Ser Leu Arg Lys Cys Cys His 
                485                 490                 495     


Arg Tyr Ser Ser Leu Asp Pro Arg Lys Val Gln Phe Tyr Phe Asn Lys 
            500                 505                 510         


Glu Asn Phe 
        515 


<210>  3834
<211>  645
<212>  PRT
<213>  Homo sapiens

<400>  3834

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
    210                 215                 220                 


Val Met Ala Ser Phe Tyr Lys His Leu Gly Ile Glu Phe Met Glu Ala 
225                 230                 235                 240 


Glu Glu Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Ile 
                245                 250                 255     


Ala Leu Leu Val Val Gly Ile Met Cys Val Val Ala Tyr Cys Lys Thr 
            260                 265                 270         


Lys Lys Gln Arg Lys Lys Leu His Asp Arg Leu Arg Gln Ser Leu Arg 
        275                 280                 285             


Ser Glu Arg Asn Asn Met Met Asn Ile Ala Asn Gly Pro His His Pro 
    290                 295                 300                 


Asn Pro Pro Pro Glu Asn Val Gln Leu Val Asn Gln Tyr Val Ser Lys 
305                 310                 315                 320 


Asn Val Ile Ser Ser Glu His Ile Val Glu Arg Glu Ala Glu Thr Ser 
                325                 330                 335     


Phe Ser Thr Ser His Tyr Thr Ser Thr Ala His His Ser Thr Thr Val 
            340                 345                 350         


Thr Gln Thr Pro Ser His Ser Trp Ser Asn Gly His Thr Glu Ser Ile 
        355                 360                 365             


Leu Ser Glu Ser His Ser Val Ile Val Met Ser Ser Val Glu Asn Ser 
    370                 375                 380                 


Arg His Ser Ser Pro Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr 
385                 390                 395                 400 


Gly Gly Pro Arg Glu Cys Asn Ser Phe Leu Arg His Ala Arg Glu Thr 
                405                 410                 415     


Pro Asp Ser Tyr Arg Asp Ser Pro His Ser Glu Arg Tyr Val Ser Ala 
            420                 425                 430         


Met Thr Thr Pro Ala Arg Met Ser Pro Val Asp Phe His Thr Pro Ser 
        435                 440                 445             


Ser Pro Lys Ser Pro Pro Ser Glu Met Ser Pro Pro Val Ser Ser Met 
    450                 455                 460                 


Thr Val Ser Met Pro Ser Met Ala Val Ser Pro Phe Met Glu Glu Glu 
465                 470                 475                 480 


Arg Pro Leu Leu Leu Val Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe 
                485                 490                 495     


Asp His His Pro Gln Gln Phe Ser Ser Phe His His Asn Pro Ala His 
            500                 505                 510         


Asp Ser Asn Ser Leu Pro Ala Ser Pro Leu Arg Ile Val Glu Asp Glu 
        515                 520                 525             


Glu Tyr Glu Thr Thr Gln Glu Tyr Glu Pro Ala Gln Glu Pro Val Lys 
    530                 535                 540                 


Lys Leu Ala Asn Ser Arg Arg Ala Lys Arg Thr Lys Pro Asn Gly His 
545                 550                 555                 560 


Ile Ala Asn Arg Leu Glu Val Asp Ser Asn Thr Ser Ser Gln Ser Ser 
                565                 570                 575     


Asn Ser Glu Ser Glu Thr Glu Asp Glu Arg Val Gly Glu Asp Thr Pro 
            580                 585                 590         


Phe Leu Gly Ile Gln Asn Pro Leu Ala Ala Ser Leu Glu Ala Thr Pro 
        595                 600                 605             


Ala Phe Arg Leu Ala Asp Ser Arg Thr Asn Pro Ala Gly Arg Phe Ser 
    610                 615                 620                 


Thr Gln Glu Glu Ile Gln Ala Arg Leu Ser Ser Val Ile Ala Asn Gln 
625                 630                 635                 640 


Asp Pro Ile Ala Val 
                645 


<210>  3835
<211>  637
<212>  PRT
<213>  Homo sapiens

<400>  3835

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
    210                 215                 220                 


Val Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Lys Arg Val 
225                 230                 235                 240 


Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly Ile Met 
                245                 250                 255     


Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys Leu His 
            260                 265                 270         


Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met Met Asn 
        275                 280                 285             


Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn Val Gln 
    290                 295                 300                 


Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu His Ile 
305                 310                 315                 320 


Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr Thr Ser 
                325                 330                 335     


Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His Ser Trp 
            340                 345                 350         


Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser Val Ile 
        355                 360                 365             


Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr Gly Gly 
    370                 375                 380                 


Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys Asn Ser 
385                 390                 395                 400 


Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp Ser Pro 
                405                 410                 415     


His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala Arg Met Ser 
            420                 425                 430         


Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro Pro Ser Glu 
        435                 440                 445             


Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro Ser Met Ala 
    450                 455                 460                 


Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu Val Thr Pro 
465                 470                 475                 480 


Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln Gln Phe Ser 
                485                 490                 495     


Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu Pro Ala Ser 
            500                 505                 510         


Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr Gln Glu Tyr 
        515                 520                 525             


Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser Arg Arg Ala 
    530                 535                 540                 


Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu Glu Val Asp 
545                 550                 555                 560 


Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu Thr Glu Asp 
                565                 570                 575     


Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln Asn Pro Leu 
            580                 585                 590         


Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala Asp Ser Arg 
        595                 600                 605             


Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile Gln Ala Arg 
    610                 615                 620                 


Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
625                 630                 635         


<210>  3836
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  3836

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
    210                 215                 220                 


Val Met Ala Ser Phe Tyr Ser Thr Ser Thr Pro Phe Leu Ser Leu Pro 
225                 230                 235                 240 


Glu 
    


<210>  3837
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  3837

Met Glu Ile Tyr Ser Pro Asp Met Ser Glu Val Ala Ala Glu Arg Ser 
1               5                   10                  15      


Ser Ser Pro Ser Thr Gln Leu Ser Ala Asp Pro Ser Leu Asp Gly Leu 
            20                  25                  30          


Pro Ala Ala Glu Asp Met Pro Glu Pro Gln Thr Glu Asp Gly Arg Thr 
        35                  40                  45              


Pro Gly Leu Val Gly Leu Ala Val Pro Cys Cys Ala Cys Leu Glu Ala 
    50                  55                  60                  


Glu Arg Leu Arg Gly Cys Leu Asn Ser Glu Lys Ile Cys Ile Val Pro 
65                  70                  75                  80  


Ile Leu Ala Cys Leu Val Ser Leu Cys Leu Cys Ile Ala Gly Leu Lys 
                85                  90                  95      


Trp Val Phe Val Asp Lys Ile Phe Glu Tyr Asp Ser Pro Thr His Leu 
            100                 105                 110         


Asp Pro Gly Gly Leu Gly Gln Asp Pro Ile Ile Ser Leu Asp Ala Thr 
        115                 120                 125             


Ala Ala Ser Ala Val Trp Val Ser Ser Glu Ala Tyr Thr Ser Pro Val 
    130                 135                 140                 


Ser Arg Ala Gln Ser Glu Ser Glu Val Gln Val Thr Val Gln Gly Asp 
145                 150                 155                 160 


Lys Ala Val Val Ser Phe Glu Pro Ser Ala Ala Pro Thr Pro Lys Asn 
                165                 170                 175     


Arg Ile Phe Ala Phe Ser Phe Leu Pro Ser Thr Ala Pro Ser Phe Pro 
            180                 185                 190         


Ser Pro Thr Arg Asn Pro Glu Val Arg Thr Pro Lys Ser Ala Thr Gln 
        195                 200                 205             


Pro Gln Thr Thr Glu Thr Asn Leu Gln Thr Ala Pro Lys Leu Ser Thr 
    210                 215                 220                 


Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys 
225                 230                 235                 240 


Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp 
                245                 250                 255     


Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu Phe Thr 
            260                 265                 270         


Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr Ser Thr Ser 
        275                 280                 285             


Thr Pro Phe Leu Ser Leu Pro Glu 
    290                 295     


<210>  3838
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  3838

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys Cys Gln Pro Gly Phe Thr Gly Ala Arg Cys Thr Glu Asn 
    210                 215                 220                 


Val Pro Met Lys Val Gln Asn Gln Glu Lys Ala Glu Glu Leu Tyr Gln 
225                 230                 235                 240 


Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val 
                245                 250                 255     


Gly Ile Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys 
            260                 265                 270         


Lys Leu His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn 
        275                 280                 285             


Met Met Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu 
    290                 295                 300                 


Asn Val Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser 
305                 310                 315                 320 


Glu His Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His 
                325                 330                 335     


Tyr Thr Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser 
            340                 345                 350         


His Ser Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His 
        355                 360                 365             


Ser Val Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro 
    370                 375                 380                 


Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu 
385                 390                 395                 400 


Cys Asn Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg 
                405                 410                 415     


Asp Ser Pro His Ser Glu Arg His Asn Leu Ile Ala Glu Leu Arg Arg 
            420                 425                 430         


Asn Lys Ala His Arg Ser Lys Cys Met Gln Ile Gln Leu Ser Ala Thr 
        435                 440                 445             


His Leu Arg Ser Ser Ser Ile Pro His Leu Gly Phe Ile Leu 
    450                 455                 460         


<210>  3839
<211>  607
<212>  PRT
<213>  Homo sapiens

<400>  3839

Met Gly Lys Gly Arg Ala Gly Arg Val Gly Thr Thr Ala Leu Pro Pro 
1               5                   10                  15      


Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala Ala Gly Ser Lys Leu 
            20                  25                  30          


Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser Ser Leu Arg Phe Lys 
        35                  40                  45              


Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys Asn Lys Pro Gln Asn 
    50                  55                  60                  


Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu Leu Arg Ile Asn Lys 
65                  70                  75                  80  


Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys Lys Val Ile Ser Lys 
                85                  90                  95      


Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr Ile Val Glu Ser Asn 
            100                 105                 110         


Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu Gly Ala Tyr Val Ser 
        115                 120                 125             


Ser Ala Thr Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys 
    130                 135                 140                 


Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met 
145                 150                 155                 160 


Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn 
                165                 170                 175     


Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr 
            180                 185                 190         


Lys His Leu Gly Ile Glu Phe Met Glu Ala Glu Glu Leu Tyr Gln Lys 
        195                 200                 205             


Arg Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly 
    210                 215                 220                 


Ile Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys 
225                 230                 235                 240 


Leu His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met 
                245                 250                 255     


Met Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn 
            260                 265                 270         


Val Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu 
        275                 280                 285             


His Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr 
    290                 295                 300                 


Thr Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His 
305                 310                 315                 320 


Ser Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser 
                325                 330                 335     


Val Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr 
            340                 345                 350         


Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys 
        355                 360                 365             


Asn Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp 
    370                 375                 380                 


Ser Pro His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala Arg 
385                 390                 395                 400 


Met Ser Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro Pro 
                405                 410                 415     


Ser Glu Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro Ser 
            420                 425                 430         


Met Ala Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu Val 
        435                 440                 445             


Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln Gln 
    450                 455                 460                 


Phe Ser Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu Pro 
465                 470                 475                 480 


Ala Ser Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr Gln 
                485                 490                 495     


Glu Tyr Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser Arg 
            500                 505                 510         


Arg Ala Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu Glu 
        515                 520                 525             


Val Asp Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu Thr 
    530                 535                 540                 


Glu Asp Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln Asn 
545                 550                 555                 560 


Pro Leu Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala Asp 
                565                 570                 575     


Ser Arg Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile Gln 
            580                 585                 590         


Ala Arg Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
        595                 600                 605         


<210>  3840
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  3840

Met Arg Trp Arg Arg Ala Pro Arg Arg Ser Gly Arg Pro Gly Pro Arg 
1               5                   10                  15      


Ala Gln Arg Pro Gly Ser Ala Ala Arg Ser Ser Pro Pro Leu Pro Leu 
            20                  25                  30          


Leu Pro Leu Leu Leu Leu Leu Gly Thr Ala Ala Leu Ala Pro Gly Ala 
        35                  40                  45              


Ala Ala Gly Asn Glu Ala Ala Pro Ala Gly Ala Ser Val Cys Tyr Ser 
    50                  55                  60                  


Ser Pro Pro Ser Val Gly Ser Val Gln Glu Leu Ala Gln Arg Ala Ala 
65                  70                  75                  80  


Val Val Ile Glu Gly Lys Val His Pro Gln Arg Arg Gln Gln Gly Ala 
                85                  90                  95      


Leu Asp Arg Lys Ala Ala Ala Ala Ala Gly Glu Ala Gly Ala Trp Gly 
            100                 105                 110         


Gly Asp Arg Glu Pro Pro Ala Ala Gly Pro Arg Ala Leu Gly Pro Pro 
        115                 120                 125             


Ala Glu Glu Pro Leu Leu Ala Ala Asn Gly Thr Val Pro Ser Trp Pro 
    130                 135                 140                 


Thr Ala Pro Val Pro Ser Ala Gly Glu Pro Gly Glu Glu Ala Pro Tyr 
145                 150                 155                 160 


Leu Val Lys Val His Gln Val Trp Ala Val Lys Ala Gly Gly Leu Lys 
                165                 170                 175     


Lys Asp Ser Leu Leu Thr Val Arg Leu Gly Thr Trp Gly His Pro Ala 
            180                 185                 190         


Phe Pro Ser Cys Gly Arg Leu Lys Glu Asp Ser Arg Tyr Ile Phe Phe 
        195                 200                 205             


Met Glu Pro Asp Ala Asn Ser Thr Ser Arg Ala Pro Ala Ala Phe Arg 
    210                 215                 220                 


Ala Ser Phe Pro Pro Leu Glu Thr Gly Arg Asn Leu Lys Lys Glu Val 
225                 230                 235                 240 


Ser Arg Val Leu Cys Lys Arg Cys Ala Leu Pro Pro Arg Leu Lys Glu 
                245                 250                 255     


Met Lys Ser Gln Glu Ser Ala Ala Gly Ser Lys Leu Val Leu Arg Cys 
            260                 265                 270         


Glu Thr Ser Ser Glu Tyr Ser Ser Leu Arg Phe Lys Trp Phe Lys Asn 
        275                 280                 285             


Gly Asn Glu Leu Asn Arg Lys Asn Lys Pro Gln Asn Ile Lys Ile Gln 
    290                 295                 300                 


Lys Lys Pro Gly Lys Ser Glu Leu Arg Ile Asn Lys Ala Ser Leu Ala 
305                 310                 315                 320 


Asp Ser Gly Glu Tyr Met Cys Lys Val Ile Ser Lys Leu Gly Asn Asp 
                325                 330                 335     


Ser Ala Ser Ala Asn Ile Thr Ile Val Glu Ser Asn Ala Thr Ser Thr 
            340                 345                 350         


Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys 
        355                 360                 365             


Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser 
    370                 375                 380                 


Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp 
385                 390                 395                 400 


Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr Ser Thr Ser Thr Pro 
                405                 410                 415     


Phe Leu Ser Leu Pro Glu 
            420         


<210>  3841
<211>  640
<212>  PRT
<213>  Homo sapiens

<400>  3841

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys Cys Gln Pro Gly Phe Thr Gly Ala Arg Cys Thr Glu Asn 
    210                 215                 220                 


Val Pro Met Lys Val Gln Asn Gln Glu Lys Ala Glu Glu Leu Tyr Gln 
225                 230                 235                 240 


Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val 
                245                 250                 255     


Gly Ile Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys 
            260                 265                 270         


Lys Leu His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn 
        275                 280                 285             


Met Met Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu 
    290                 295                 300                 


Asn Val Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser 
305                 310                 315                 320 


Glu His Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His 
                325                 330                 335     


Tyr Thr Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser 
            340                 345                 350         


His Ser Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His 
        355                 360                 365             


Ser Val Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro 
    370                 375                 380                 


Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu 
385                 390                 395                 400 


Cys Asn Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg 
                405                 410                 415     


Asp Ser Pro His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala 
            420                 425                 430         


Arg Met Ser Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro 
        435                 440                 445             


Pro Ser Glu Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro 
    450                 455                 460                 


Ser Met Ala Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu 
465                 470                 475                 480 


Val Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln 
                485                 490                 495     


Gln Phe Ser Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu 
            500                 505                 510         


Pro Ala Ser Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr 
        515                 520                 525             


Gln Glu Tyr Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser 
    530                 535                 540                 


Arg Arg Ala Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu 
545                 550                 555                 560 


Glu Val Asp Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu 
                565                 570                 575     


Thr Glu Asp Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln 
            580                 585                 590         


Asn Pro Leu Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala 
        595                 600                 605             


Asp Ser Arg Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile 
    610                 615                 620                 


Gln Ala Arg Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
625                 630                 635                 640 


<210>  3842
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  3842

Met Ala Ala Pro Gln Asp Val His Val Arg Ile Cys Asn Gln Glu Ile 
1               5                   10                  15      


Val Lys Phe Asp Leu Glu Val Lys Ala Leu Ile Gln Asp Ile Arg Asp 
            20                  25                  30          


Cys Ser Gly Pro Leu Ser Ala Leu Thr Glu Leu Asn Thr Lys Val Lys 
        35                  40                  45              


Glu Lys Phe Gln Gln Leu Arg His Arg Ile Gln Asp Leu Glu Gln Leu 
    50                  55                  60                  


Ala Lys Glu Gln Asp Lys Glu Ser Glu Lys Gln Leu Leu Leu Gln Glu 
65                  70                  75                  80  


Val Glu Asn His Lys Lys Gln Met Leu Arg Lys Thr Thr Lys Glu Ser 
                85                  90                  95      


Leu Ala Gln Thr Ser Ser Thr Ile Thr Glu Ser Leu Met Gly Ile Ser 
            100                 105                 110         


Arg Met Met Ala Gln Gln Val Gln Gln Ser Glu Glu Ala Met Gln Ser 
        115                 120                 125             


Leu Val Thr Ser Ser Arg Thr Ile Leu Asp Ala Asn Glu Glu Phe Lys 
    130                 135                 140                 


Ser Met Ser Gly Thr Ile Gln Leu Gly Arg Lys Leu Ile Thr Lys Tyr 
145                 150                 155                 160 


Asn Arg Arg Glu Leu Thr Asp Lys Leu Leu Ile Phe Leu Ala Leu Ala 
                165                 170                 175     


Leu Phe Leu Ala Thr Val Leu Tyr Ile Val Lys Lys Arg Leu Phe Pro 
            180                 185                 190         


Phe Leu 
        


<210>  3843
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  3843

Met Ala Ala Pro Gln Asp Val His Val Arg Ile Cys Asn Gln Glu Ile 
1               5                   10                  15      


Val Lys Phe Asp Leu Glu Val Lys Ala Leu Ile Gln Asp Ile Arg Asp 
            20                  25                  30          


Cys Ser Gly Pro Leu Ser Ala Leu Thr Glu Leu Asn Thr Lys Val Lys 
        35                  40                  45              


Glu Lys Phe Gln Gln Leu Arg His Arg Ile Gln Pro Val Leu Tyr Gln 
    50                  55                  60                  


Arg Ala Phe Ile Trp Thr Ala Ser Thr Phe Phe Phe Lys Leu Thr Tyr 
65                  70                  75                  80  


Ser Leu Thr Asp Phe Ser Ser Thr Gln His Asp Phe Asn Ser Pro Thr 
                85                  90                  95      


Thr Pro Val Thr Phe Ser Asp Leu Glu Gln Leu Ala Lys Glu Gln Asp 
            100                 105                 110         


Lys Glu Ser Glu Lys Gln Leu Leu Leu Gln Glu Val Glu Asn His Lys 
        115                 120                 125             


Lys Gln Met Leu Ser Asn Gln Ala Ser Trp Arg Lys Ala Asn Leu Thr 
    130                 135                 140                 


Cys Lys Ile Ala Ile Asp Asn Leu Glu Lys Ala Glu Leu Leu Gln Gly 
145                 150                 155                 160 


Gly Asp Leu Leu Arg Gln Arg Lys Thr Thr Lys Glu Ser Leu Ala Gln 
                165                 170                 175     


Thr Ser Ser Thr Ile Thr Glu Ser Leu Met Gly Ile Ser Arg Met Met 
            180                 185                 190         


Ala Gln Gln Val Gln Gln Ser Glu Glu Ala Met Gln Ser Leu Val Thr 
        195                 200                 205             


Ser Ser Arg Thr Ile Leu Asp Ala Asn Glu Glu Phe Lys Ser Met Ser 
    210                 215                 220                 


Gly Thr Ile Gln Leu Gly Arg Lys Leu Ile Thr Lys Tyr Asn Arg Arg 
225                 230                 235                 240 


Glu Leu Thr Asp Lys Leu Leu Ile Phe Leu Ala Leu Ala Leu Phe Leu 
                245                 250                 255     


Ala Thr Val Leu Tyr Ile Val Lys Lys Arg Leu Phe Pro Phe Leu 
            260                 265                 270     


<210>  3844
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  3844

Met Ala Ala Pro Gln Asp Val His Val Arg Ile Cys Asn Gln Glu Ile 
1               5                   10                  15      


Val Lys Phe Asp Leu Glu Val Lys Ala Leu Ile Gln Asp Ile Arg Asp 
            20                  25                  30          


Cys Ser Gly Pro Leu Ser Ala Leu Thr Glu Leu Asn Thr Lys Val Lys 
        35                  40                  45              


Glu Lys Phe Gln Gln Leu Arg His Arg Ile Gln Pro Val Leu Tyr Gln 
    50                  55                  60                  


Arg Ala Phe Ile Trp Thr Ala Ser Thr Phe Phe Phe Lys Leu Thr Tyr 
65                  70                  75                  80  


Ser Leu Thr Asp Phe Ser Ser Thr Gln His Asp Phe Asn Ser Pro Thr 
                85                  90                  95      


Thr Pro Val Thr Phe Ser Asp Leu Glu Gln Leu Ala Lys Glu Gln Asp 
            100                 105                 110         


Lys Glu Ser Glu Lys Gln Leu Leu Leu Gln Glu Val Glu Asn His Lys 
        115                 120                 125             


Lys Gln Met Leu Arg Lys Thr Thr Lys Glu Ser Leu Ala Gln Thr Ser 
    130                 135                 140                 


Ser Thr Ile Thr Glu Ser Leu Met Gly Ile Ser Arg Met Met Ala Gln 
145                 150                 155                 160 


Gln Val Gln Gln Ser Glu Glu Ala Met Gln Ser Leu Val Thr Ser Ser 
                165                 170                 175     


Arg Thr Ile Leu Asp Ala Asn Glu Glu Phe Lys Ser Met Ser Gly Thr 
            180                 185                 190         


Ile Gln Leu Gly Arg Lys Leu Ile Thr Lys Tyr Asn Arg Arg Glu Leu 
        195                 200                 205             


Thr Asp Lys Leu Leu Ile Phe Leu Ala Leu Ala Leu Phe Leu Ala Thr 
    210                 215                 220                 


Val Leu Tyr Ile Val Lys Lys Arg Leu Phe Pro Phe Leu 
225                 230                 235         


<210>  3845
<211>  844
<212>  PRT
<213>  Homo sapiens

<400>  3845

Met Arg Gln Val Cys Cys Ser Ala Leu Pro Pro Pro Pro Leu Glu Lys 
1               5                   10                  15      


Gly Arg Cys Ser Ser Tyr Ser Asp Ser Ser Ser Ser Ser Ser Glu Arg 
            20                  25                  30          


Ser Ser Ser Ser Ser Ser Ser Ser Ser Glu Ser Gly Ser Ser Ser Arg 
        35                  40                  45              


Ser Ser Ser Asn Asn Ser Ser Ile Ser Arg Pro Ala Ala Pro Pro Glu 
    50                  55                  60                  


Pro Arg Pro Gln Gln Gln Pro Gln Pro Arg Ser Pro Ala Ala Arg Arg 
65                  70                  75                  80  


Ala Ala Ala Arg Ser Arg Ala Ala Ala Ala Gly Gly Met Arg Arg Asp 
                85                  90                  95      


Pro Ala Pro Gly Phe Ser Met Leu Leu Phe Gly Val Ser Leu Ala Cys 
            100                 105                 110         


Tyr Ser Pro Ser Leu Lys Ser Val Gln Asp Gln Ala Tyr Lys Ala Pro 
        115                 120                 125             


Val Val Val Glu Gly Lys Val Gln Gly Leu Val Pro Ala Gly Gly Ser 
    130                 135                 140                 


Ser Ser Asn Ser Thr Arg Glu Pro Pro Ala Ser Gly Arg Val Ala Leu 
145                 150                 155                 160 


Val Lys Val Leu Asp Lys Trp Pro Leu Arg Ser Gly Gly Leu Gln Arg 
                165                 170                 175     


Glu Gln Val Ile Ser Val Gly Ser Cys Val Pro Leu Glu Arg Asn Gln 
            180                 185                 190         


Arg Tyr Ile Phe Phe Leu Glu Pro Thr Glu Gln Pro Leu Val Phe Lys 
        195                 200                 205             


Thr Ala Phe Ala Pro Leu Asp Thr Asn Gly Lys Asn Leu Lys Lys Glu 
    210                 215                 220                 


Val Gly Lys Ile Leu Cys Thr Asp Cys Ala Thr Arg Pro Lys Leu Lys 
225                 230                 235                 240 


Lys Met Lys Ser Gln Thr Gly Gln Val Gly Glu Lys Gln Ser Leu Lys 
                245                 250                 255     


Cys Glu Ala Ala Ala Gly Asn Pro Gln Pro Ser Tyr Arg Trp Phe Lys 
            260                 265                 270         


Asp Gly Lys Glu Leu Asn Arg Ser Arg Asp Ile Arg Ile Lys Tyr Gly 
        275                 280                 285             


Asn Gly Arg Lys Asn Ser Arg Leu Gln Phe Asn Lys Val Lys Val Glu 
    290                 295                 300                 


Asp Ala Gly Glu Tyr Val Cys Glu Ala Glu Asn Ile Leu Gly Lys Asp 
305                 310                 315                 320 


Thr Val Arg Gly Arg Leu Tyr Val Asn Ser Val Ser Thr Thr Leu Ser 
                325                 330                 335     


Ser Trp Ser Gly His Ala Arg Lys Cys Asn Glu Thr Ala Lys Ser Tyr 
            340                 345                 350         


Cys Val Asn Gly Gly Val Cys Tyr Tyr Ile Glu Gly Ile Asn Gln Leu 
        355                 360                 365             


Ser Cys Lys Cys Pro Val Gly Tyr Thr Gly Asp Arg Cys Gln Gln Phe 
    370                 375                 380                 


Ala Met Val Asn Phe Ser Lys Ala Glu Glu Leu Tyr Gln Lys Arg Val 
385                 390                 395                 400 


Leu Thr Ile Thr Gly Ile Cys Val Ala Leu Leu Val Val Gly Ile Val 
                405                 410                 415     


Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Gln Met His 
            420                 425                 430         


Asn His Leu Arg Gln Asn Met Cys Pro Ala His Gln Asn Arg Ser Leu 
        435                 440                 445             


Ala Asn Gly Pro Ser His Pro Arg Leu Asp Pro Glu Glu Ile Gln Met 
    450                 455                 460                 


Ala Asp Tyr Ile Ser Lys Asn Val Pro Ala Thr Asp His Val Ile Arg 
465                 470                 475                 480 


Arg Glu Thr Glu Thr Thr Phe Ser Gly Ser His Ser Cys Ser Pro Ser 
                485                 490                 495     


His His Cys Ser Thr Ala Thr Pro Thr Ser Ser His Arg His Glu Ser 
            500                 505                 510         


His Thr Trp Ser Leu Glu Arg Ser Glu Ser Leu Thr Ser Asp Ser Gln 
        515                 520                 525             


Ser Gly Ile Met Leu Ser Ser Val Gly Thr Ser Lys Cys Asn Ser Pro 
    530                 535                 540                 


Ala Cys Val Glu Ala Arg Ala Arg Arg Ala Ala Ala Tyr Asn Leu Glu 
545                 550                 555                 560 


Glu Arg Arg Arg Ala Thr Ala Pro Pro Tyr His Asp Ser Val Asp Ser 
                565                 570                 575     


Leu Arg Asp Ser Pro His Ser Glu Arg Tyr Val Ser Ala Leu Thr Thr 
            580                 585                 590         


Pro Ala Arg Leu Ser Pro Val Asp Phe His Tyr Ser Leu Ala Thr Gln 
        595                 600                 605             


Val Pro Thr Phe Glu Ile Thr Ser Pro Asn Ser Ala His Ala Val Ser 
    610                 615                 620                 


Leu Pro Pro Ala Ala Pro Ile Ser Tyr Arg Leu Ala Glu Gln Gln Pro 
625                 630                 635                 640 


Leu Leu Arg His Pro Ala Pro Pro Gly Pro Gly Pro Gly Pro Gly Pro 
                645                 650                 655     


Gly Pro Gly Pro Gly Ala Asp Met Gln Arg Ser Tyr Asp Ser Tyr Tyr 
            660                 665                 670         


Tyr Pro Ala Ala Gly Pro Gly Pro Arg Arg Gly Thr Cys Ala Leu Gly 
        675                 680                 685             


Gly Ser Leu Gly Ser Leu Pro Ala Ser Pro Phe Arg Ile Pro Glu Asp 
    690                 695                 700                 


Asp Glu Tyr Glu Thr Thr Gln Glu Cys Ala Pro Pro Pro Pro Pro Arg 
705                 710                 715                 720 


Pro Arg Ala Arg Gly Ala Ser Arg Arg Thr Ser Ala Gly Pro Arg Arg 
                725                 730                 735     


Trp Arg Arg Ser Arg Leu Asn Gly Leu Ala Ala Gln Arg Ala Arg Ala 
            740                 745                 750         


Ala Arg Asp Ser Leu Ser Leu Ser Ser Gly Ser Gly Gly Gly Ser Ala 
        755                 760                 765             


Ser Ala Ser Asp Asp Asp Ala Asp Asp Ala Asp Gly Ala Leu Ala Ala 
    770                 775                 780                 


Glu Ser Thr Pro Phe Leu Gly Leu Arg Gly Ala His Asp Ala Leu Arg 
785                 790                 795                 800 


Ser Asp Ser Pro Pro Leu Cys Pro Ala Ala Asp Ser Arg Thr Tyr Tyr 
                805                 810                 815     


Ser Leu Asp Ser His Ser Thr Arg Ala Ser Ser Arg His Ser Arg Gly 
            820                 825                 830         


Pro Pro Pro Arg Ala Lys Gln Asp Ser Ala Pro Leu 
        835                 840                 


<210>  3846
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  3846

Met Arg Gln Val Cys Cys Ser Ala Leu Pro Pro Pro Pro Leu Glu Lys 
1               5                   10                  15      


Gly Arg Cys Ser Ser Tyr Ser Asp Ser Ser Ser Ser Ser Ser Glu Arg 
            20                  25                  30          


Ser Ser Ser Ser Ser Ser Ser Ser Ser Glu Ser Gly Ser Ser Ser Arg 
        35                  40                  45              


Ser Ser Ser Asn Asn Ser Ser Ile Ser Arg Pro Ala Ala Pro Pro Glu 
    50                  55                  60                  


Pro Arg Pro Gln Gln Gln Pro Gln Pro Arg Ser Pro Ala Ala Arg Arg 
65                  70                  75                  80  


Ala Ala Ala Arg Ser Arg Ala Ala Ala Ala Gly Gly Met Arg Arg Asp 
                85                  90                  95      


Pro Ala Pro Gly Phe Ser Met Leu Leu Phe Gly Val Ser Leu Ala Cys 
            100                 105                 110         


Tyr Ser Pro Ser Leu Lys Ser Val Gln Asp Gln Ala Tyr Lys Ala Pro 
        115                 120                 125             


Val Val Val Glu Gly Lys Val Gln Gly Leu Val Pro Ala Gly Gly Ser 
    130                 135                 140                 


Ser Ser Asn Ser Thr Arg Glu Pro Pro Ala Ser Gly Arg Val Ala Leu 
145                 150                 155                 160 


Val Lys Val Leu Asp Lys Trp Pro Leu Arg Ser Gly Gly Leu Gln Arg 
                165                 170                 175     


Glu Gln Val Ile Ser Val Gly Ser Cys Val Pro Leu Glu Arg Asn Gln 
            180                 185                 190         


Arg Tyr Ile Phe Phe Leu Glu Pro Thr Glu Gln Pro Leu Val Phe Lys 
        195                 200                 205             


Thr Ala Phe Ala Pro Leu Asp Thr Asn Gly Lys Asn Leu Lys Lys Glu 
    210                 215                 220                 


Val Gly Lys Ile Leu Cys Thr Asp Cys Ala Thr Arg Pro Lys Leu Lys 
225                 230                 235                 240 


Lys Met Lys Ser Gln Thr Gly Gln Val Gly Glu Lys Gln Ser Leu Lys 
                245                 250                 255     


Cys Glu Ala Ala Ala Gly Asn Pro Gln Pro Ser Tyr Arg Trp Phe Lys 
            260                 265                 270         


Asp Gly Lys Glu Leu Asn Arg Ser Arg Asp Ile Arg Ile Lys Tyr Gly 
        275                 280                 285             


Asn Gly Arg Lys Asn Ser Arg Leu Gln Phe Asn Lys Val Lys Val Glu 
    290                 295                 300                 


Asp Ala Gly Glu Tyr Val Cys Glu Ala Glu Asn Ile Leu Gly Lys Asp 
305                 310                 315                 320 


Thr Val Arg Gly Arg Leu Tyr Val Asn Ser Val Ser Thr Thr Leu Ser 
                325                 330                 335     


Ser Trp Ser Gly His Ala Arg Lys Cys Asn Glu Thr Ala Lys Ser Tyr 
            340                 345                 350         


Cys Val Asn Gly Gly Val Cys Tyr Tyr Ile Glu Gly Ile Asn Gln Leu 
        355                 360                 365             


Ser Cys Lys Cys Pro Asn Gly Phe Phe Gly Gln Arg Cys Leu Glu Lys 
    370                 375                 380                 


Leu Pro Leu Arg Leu Tyr Met Pro Asp Pro Lys Gln Lys His Leu Gly 
385                 390                 395                 400 


Phe Glu Leu Lys Glu Ala Glu Glu Leu Tyr Gln Lys Arg Val Leu Thr 
                405                 410                 415     


Ile Thr Gly Ile Cys Val Ala Leu Leu Val Val Gly Ile Val Cys Val 
            420                 425                 430         


Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Gln Met His Asn His 
        435                 440                 445             


Leu Arg Gln Asn Met Cys Pro Ala His Gln Asn Arg Ser Leu Ala Asn 
    450                 455                 460                 


Gly Pro Ser His Pro Arg Leu Asp Pro Glu Glu Ile Gln Met Ala Asp 
465                 470                 475                 480 


Tyr Ile Ser Lys Asn Val Pro Ala Thr Asp His Val Ile Arg Arg Glu 
                485                 490                 495     


Thr Glu Thr Thr Phe Ser Gly Ser His Ser Cys Ser Pro Ser His His 
            500                 505                 510         


Cys Ser Thr Ala Thr Pro Thr Ser Ser His Arg His Glu Ser His Thr 
        515                 520                 525             


Trp Ser Leu Glu Arg Ser Glu Ser Leu Thr Ser Asp Ser Gln Ser Gly 
    530                 535                 540                 


Ile Met Leu Ser Ser Val Gly Thr Ser Lys Cys Asn Ser Pro Ala Cys 
545                 550                 555                 560 


Val Glu Ala Arg Ala Arg Arg Ala Ala Ala Tyr Asn Leu Glu Glu Arg 
                565                 570                 575     


Arg Arg Ala Thr Ala Pro Pro Tyr His Asp Ser Val Asp Ser Leu Arg 
            580                 585                 590         


Asp Ser Pro His Ser Glu Arg Tyr Val Ser Ala Leu Thr Thr Pro Ala 
        595                 600                 605             


Arg Leu Ser Pro Val Asp Phe His Tyr Ser Leu Ala Thr Gln Val Pro 
    610                 615                 620                 


Thr Phe Glu Ile Thr Ser Pro Asn Ser Ala His Ala Val Ser Leu Pro 
625                 630                 635                 640 


Pro Ala Ala Pro Ile Ser Tyr Arg Leu Ala Glu Gln Gln Pro Leu Leu 
                645                 650                 655     


Arg His Pro Ala Pro Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro 
            660                 665                 670         


Gly Pro Gly Ala Asp Met Gln Arg Ser Tyr Asp Ser Tyr Tyr Tyr Pro 
        675                 680                 685             


Ala Ala Gly Pro Gly Pro Arg Arg Gly Thr Cys Ala Leu Gly Gly Ser 
    690                 695                 700                 


Leu Gly Ser Leu Pro Ala Ser Pro Phe Arg Ile Pro Glu Asp Asp Glu 
705                 710                 715                 720 


Tyr Glu Thr Thr Gln Glu Cys Ala Pro Pro Pro Pro Pro Arg Pro Arg 
                725                 730                 735     


Ala Arg Gly Ala Ser Arg Arg Thr Ser Ala Gly Pro Arg Arg Trp Arg 
            740                 745                 750         


Arg Ser Arg Leu Asn Gly Leu Ala Ala Gln Arg Ala Arg Ala Ala Arg 
        755                 760                 765             


Asp Ser Leu Ser Leu Ser Ser Gly Ser Gly Gly Gly Ser Ala Ser Ala 
    770                 775                 780                 


Ser Asp Asp Asp Ala Asp Asp Ala Asp Gly Ala Leu Ala Ala Glu Ser 
785                 790                 795                 800 


Thr Pro Phe Leu Gly Leu Arg Gly Ala His Asp Ala Leu Arg Ser Asp 
                805                 810                 815     


Ser Pro Pro Leu Cys Pro Ala Ala Asp Ser Arg Thr Tyr Tyr Ser Leu 
            820                 825                 830         


Asp Ser His Ser Thr Arg Ala Ser Ser Arg His Ser Arg Gly Pro Pro 
        835                 840                 845             


Pro Arg Ala Lys Gln Asp Ser Ala Pro Leu 
    850                 855             


<210>  3847
<211>  852
<212>  PRT
<213>  Homo sapiens

<400>  3847

Met Arg Gln Val Cys Cys Ser Ala Leu Pro Pro Pro Pro Leu Glu Lys 
1               5                   10                  15      


Gly Arg Cys Ser Ser Tyr Ser Asp Ser Ser Ser Ser Ser Ser Glu Arg 
            20                  25                  30          


Ser Ser Ser Ser Ser Ser Ser Ser Ser Glu Ser Gly Ser Ser Ser Arg 
        35                  40                  45              


Ser Ser Ser Asn Asn Ser Ser Ile Ser Arg Pro Ala Ala Pro Pro Glu 
    50                  55                  60                  


Pro Arg Pro Gln Gln Gln Pro Gln Pro Arg Ser Pro Ala Ala Arg Arg 
65                  70                  75                  80  


Ala Ala Ala Arg Ser Arg Ala Ala Ala Ala Gly Gly Met Arg Arg Asp 
                85                  90                  95      


Pro Ala Pro Gly Phe Ser Met Leu Leu Phe Gly Val Ser Leu Ala Cys 
            100                 105                 110         


Tyr Ser Pro Ser Leu Lys Ser Val Gln Asp Gln Ala Tyr Lys Ala Pro 
        115                 120                 125             


Val Val Val Glu Gly Lys Val Gln Gly Leu Val Pro Ala Gly Gly Ser 
    130                 135                 140                 


Ser Ser Asn Ser Thr Arg Glu Pro Pro Ala Ser Gly Arg Val Ala Leu 
145                 150                 155                 160 


Val Lys Val Leu Asp Lys Trp Pro Leu Arg Ser Gly Gly Leu Gln Arg 
                165                 170                 175     


Glu Gln Val Ile Ser Val Gly Ser Cys Val Pro Leu Glu Arg Asn Gln 
            180                 185                 190         


Arg Tyr Ile Phe Phe Leu Glu Pro Thr Glu Gln Pro Leu Val Phe Lys 
        195                 200                 205             


Thr Ala Phe Ala Pro Leu Asp Thr Asn Gly Lys Asn Leu Lys Lys Glu 
    210                 215                 220                 


Val Gly Lys Ile Leu Cys Thr Asp Cys Ala Thr Arg Pro Lys Leu Lys 
225                 230                 235                 240 


Lys Met Lys Ser Gln Thr Gly Gln Val Gly Glu Lys Gln Ser Leu Lys 
                245                 250                 255     


Cys Glu Ala Ala Ala Gly Asn Pro Gln Pro Ser Tyr Arg Trp Phe Lys 
            260                 265                 270         


Asp Gly Lys Glu Leu Asn Arg Ser Arg Asp Ile Arg Ile Lys Tyr Gly 
        275                 280                 285             


Asn Gly Arg Lys Asn Ser Arg Leu Gln Phe Asn Lys Val Lys Val Glu 
    290                 295                 300                 


Asp Ala Gly Glu Tyr Val Cys Glu Ala Glu Asn Ile Leu Gly Lys Asp 
305                 310                 315                 320 


Thr Val Arg Gly Arg Leu Tyr Val Asn Ser Val Ser Thr Thr Leu Ser 
                325                 330                 335     


Ser Trp Ser Gly His Ala Arg Lys Cys Asn Glu Thr Ala Lys Ser Tyr 
            340                 345                 350         


Cys Val Asn Gly Gly Val Cys Tyr Tyr Ile Glu Gly Ile Asn Gln Leu 
        355                 360                 365             


Ser Cys Lys Cys Pro Val Gly Tyr Thr Gly Asp Arg Cys Gln Gln Phe 
    370                 375                 380                 


Ala Met Val Asn Phe Ser Lys His Leu Gly Phe Glu Leu Lys Glu Ala 
385                 390                 395                 400 


Glu Glu Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Val 
                405                 410                 415     


Ala Leu Leu Val Val Gly Ile Val Cys Val Val Ala Tyr Cys Lys Thr 
            420                 425                 430         


Lys Lys Gln Arg Lys Gln Met His Asn His Leu Arg Gln Asn Met Cys 
        435                 440                 445             


Pro Ala His Gln Asn Arg Ser Leu Ala Asn Gly Pro Ser His Pro Arg 
    450                 455                 460                 


Leu Asp Pro Glu Glu Ile Gln Met Ala Asp Tyr Ile Ser Lys Asn Val 
465                 470                 475                 480 


Pro Ala Thr Asp His Val Ile Arg Arg Glu Thr Glu Thr Thr Phe Ser 
                485                 490                 495     


Gly Ser His Ser Cys Ser Pro Ser His His Cys Ser Thr Ala Thr Pro 
            500                 505                 510         


Thr Ser Ser His Arg His Glu Ser His Thr Trp Ser Leu Glu Arg Ser 
        515                 520                 525             


Glu Ser Leu Thr Ser Asp Ser Gln Ser Gly Ile Met Leu Ser Ser Val 
    530                 535                 540                 


Gly Thr Ser Lys Cys Asn Ser Pro Ala Cys Val Glu Ala Arg Ala Arg 
545                 550                 555                 560 


Arg Ala Ala Ala Tyr Asn Leu Glu Glu Arg Arg Arg Ala Thr Ala Pro 
                565                 570                 575     


Pro Tyr His Asp Ser Val Asp Ser Leu Arg Asp Ser Pro His Ser Glu 
            580                 585                 590         


Arg Tyr Val Ser Ala Leu Thr Thr Pro Ala Arg Leu Ser Pro Val Asp 
        595                 600                 605             


Phe His Tyr Ser Leu Ala Thr Gln Val Pro Thr Phe Glu Ile Thr Ser 
    610                 615                 620                 


Pro Asn Ser Ala His Ala Val Ser Leu Pro Pro Ala Ala Pro Ile Ser 
625                 630                 635                 640 


Tyr Arg Leu Ala Glu Gln Gln Pro Leu Leu Arg His Pro Ala Pro Pro 
                645                 650                 655     


Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Ala Asp Met 
            660                 665                 670         


Gln Arg Ser Tyr Asp Ser Tyr Tyr Tyr Pro Ala Ala Gly Pro Gly Pro 
        675                 680                 685             


Arg Arg Gly Thr Cys Ala Leu Gly Gly Ser Leu Gly Ser Leu Pro Ala 
    690                 695                 700                 


Ser Pro Phe Arg Ile Pro Glu Asp Asp Glu Tyr Glu Thr Thr Gln Glu 
705                 710                 715                 720 


Cys Ala Pro Pro Pro Pro Pro Arg Pro Arg Ala Arg Gly Ala Ser Arg 
                725                 730                 735     


Arg Thr Ser Ala Gly Pro Arg Arg Trp Arg Arg Ser Arg Leu Asn Gly 
            740                 745                 750         


Leu Ala Ala Gln Arg Ala Arg Ala Ala Arg Asp Ser Leu Ser Leu Ser 
        755                 760                 765             


Ser Gly Ser Gly Gly Gly Ser Ala Ser Ala Ser Asp Asp Asp Ala Asp 
    770                 775                 780                 


Asp Ala Asp Gly Ala Leu Ala Ala Glu Ser Thr Pro Phe Leu Gly Leu 
785                 790                 795                 800 


Arg Gly Ala His Asp Ala Leu Arg Ser Asp Ser Pro Pro Leu Cys Pro 
                805                 810                 815     


Ala Ala Asp Ser Arg Thr Tyr Tyr Ser Leu Asp Ser His Ser Thr Arg 
            820                 825                 830         


Ala Ser Ser Arg His Ser Arg Gly Pro Pro Pro Arg Ala Lys Gln Asp 
        835                 840                 845             


Ser Ala Pro Leu 
    850         


<210>  3848
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  3848

Met Gly Ile Leu Ser Val Asp Leu Leu Ile Thr Leu Gln Ile Leu Pro 
1               5                   10                  15      


Val Phe Phe Ser Asn Cys Leu Phe Leu Ala Leu Tyr Asp Ser Val Ile 
            20                  25                  30          


Leu Leu Lys His Val Val Leu Leu Leu Ser Arg Ser Lys Ser Thr Arg 
        35                  40                  45              


Gly Glu Trp Arg Arg Met Leu Thr Ser Glu Gly Leu Arg Cys Val Trp 
    50                  55                  60                  


Lys Ser Phe Leu Leu Asp Ala Tyr Lys Gln Val Lys Leu Gly Glu Asp 
65                  70                  75                  80  


Ala Pro Asn Ser Ser Val Val His Val Ser Ser Thr Glu Gly Gly Asp 
                85                  90                  95      


Asn Ser Gly Asn Gly Thr Gln Glu Lys Ile Ala Glu Gly Ala Thr Cys 
            100                 105                 110         


His Leu Leu Asp Phe Ala Ser Pro Glu Arg Pro Leu Val Val Asn Phe 
        115                 120                 125             


Gly Ser Ala Thr Pro Pro Phe Thr Ser Gln Leu Pro Ala Phe Arg Lys 
    130                 135                 140                 


Leu Val Glu Glu Phe Ser Ser Val Ala Asp Phe Leu Leu Val Tyr Ile 
145                 150                 155                 160 


Asp Glu Ala His Pro Ser Asp Gly Trp Ala Ile Pro Gly Asp Ser Ser 
                165                 170                 175     


Leu Ser Phe Glu Val Lys Lys His Gln Asn Gln Glu Asp Arg Cys Ala 
            180                 185                 190         


Ala Ala Gln Gln Leu Leu Glu Arg Phe Ser Leu Pro Pro Gln Cys Arg 
        195                 200                 205             


Val Val Ala Asp Arg Met Asp Asn Asn Ala Asn Ile Ala Tyr Gly Val 
    210                 215                 220                 


Ala Phe Glu Arg Val Cys Ile Val Gln Arg Gln Lys Ile Ala Tyr Leu 
225                 230                 235                 240 


Gly Gly Lys Gly Pro Phe Ser Tyr Asn Leu Gln Glu Val Arg His Trp 
                245                 250                 255     


Leu Glu Lys Asn Phe Ser Lys Arg Lys Lys Thr Arg Leu Ala Gly 
            260                 265                 270     


<210>  3849
<211>  913
<212>  PRT
<213>  Homo sapiens

<400>  3849

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 


Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val 
145                 150                 155                 160 


Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val 
                165                 170                 175     


Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu 
            180                 185                 190         


Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu Ala Val 
        195                 200                 205             


Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Val Gly Gly Leu Gln 
    210                 215                 220                 


Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu Asp Asp 
225                 230                 235                 240 


Phe Arg Lys Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp Tyr Val 
                245                 250                 255     


Gly Trp Ser Asn His Ser Phe Ser Ser Gly Tyr Val Glu Met Glu Phe 
            260                 265                 270         


Glu Phe Asp Arg Leu Arg Ala Phe Gln Ala Met Gln Val His Cys Asn 
        275                 280                 285             


Asn Met His Thr Leu Gly Ala Arg Leu Pro Gly Gly Val Glu Cys Arg 
    290                 295                 300                 


Phe Arg Arg Gly Pro Ala Met Ala Trp Glu Gly Glu Pro Met Arg His 
305                 310                 315                 320 


Asn Leu Gly Gly Asn Leu Gly Asp Pro Arg Ala Arg Ala Val Ser Val 
                325                 330                 335     


Pro Leu Gly Gly Arg Val Ala Arg Phe Leu Gln Cys Arg Phe Leu Phe 
            340                 345                 350         


Ala Gly Pro Trp Leu Leu Phe Ser Glu Ile Ser Phe Ile Ser Asp Val 
        355                 360                 365             


Val Asn Asn Ser Ser Pro Ala Leu Gly Gly Thr Phe Pro Pro Ala Pro 
    370                 375                 380                 


Trp Trp Pro Pro Gly Pro Pro Pro Thr Asn Phe Ser Ser Leu Glu Leu 
385                 390                 395                 400 


Glu Pro Arg Gly Gln Gln Pro Val Ala Lys Ala Glu Gly Ser Pro Thr 
                405                 410                 415     


Ala Ile Leu Ile Gly Cys Leu Val Ala Ile Ile Leu Leu Leu Leu Leu 
            420                 425                 430         


Ile Ile Ala Leu Met Leu Trp Arg Leu His Trp Arg Arg Leu Leu Ser 
        435                 440                 445             


Lys Ala Glu Arg Arg Val Leu Glu Glu Glu Leu Thr Val His Leu Ser 
    450                 455                 460                 


Val Pro Gly Asp Thr Ile Leu Ile Asn Asn Arg Pro Gly Pro Arg Glu 
465                 470                 475                 480 


Pro Pro Pro Tyr Gln Glu Pro Arg Pro Arg Gly Asn Pro Pro His Ser 
                485                 490                 495     


Ala Pro Cys Val Pro Asn Gly Ser Ala Leu Leu Leu Ser Asn Pro Ala 
            500                 505                 510         


Tyr Arg Leu Leu Leu Ala Thr Tyr Ala Arg Pro Pro Arg Gly Pro Gly 
        515                 520                 525             


Pro Pro Thr Pro Ala Trp Ala Lys Pro Thr Asn Thr Gln Ala Tyr Ser 
    530                 535                 540                 


Gly Asp Tyr Met Glu Pro Glu Lys Pro Gly Ala Pro Leu Leu Pro Pro 
545                 550                 555                 560 


Pro Pro Gln Asn Ser Val Pro His Tyr Ala Glu Ala Asp Ile Val Thr 
                565                 570                 575     


Leu Gln Gly Val Thr Gly Gly Asn Thr Tyr Ala Val Pro Ala Leu Pro 
            580                 585                 590         


Pro Gly Ala Val Gly Asp Gly Pro Pro Arg Val Asp Phe Pro Arg Ser 
        595                 600                 605             


Arg Leu Arg Phe Lys Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu Val 
    610                 615                 620                 


His Leu Cys Glu Val Asp Ser Pro Gln Asp Leu Val Ser Leu Asp Phe 
625                 630                 635                 640 


Pro Leu Asn Val Arg Lys Gly His Pro Leu Leu Val Ala Val Lys Ile 
                645                 650                 655     


Leu Arg Pro Asp Ala Thr Lys Asn Ala Arg Asn Asp Phe Leu Lys Glu 
            660                 665                 670         


Val Lys Ile Met Ser Arg Leu Lys Asp Pro Asn Ile Ile Arg Leu Leu 
        675                 680                 685             


Gly Val Cys Val Gln Asp Asp Pro Leu Cys Met Ile Thr Asp Tyr Met 
    690                 695                 700                 


Glu Asn Gly Asp Leu Asn Gln Phe Leu Ser Ala His Gln Leu Glu Asp 
705                 710                 715                 720 


Lys Ala Ala Glu Gly Ala Pro Gly Asp Gly Gln Ala Ala Gln Gly Pro 
                725                 730                 735     


Thr Ile Ser Tyr Pro Met Leu Leu His Val Ala Ala Gln Ile Ala Ser 
            740                 745                 750         


Gly Met Arg Tyr Leu Ala Thr Leu Asn Phe Val His Arg Asp Leu Ala 
        755                 760                 765             


Thr Arg Asn Cys Leu Val Gly Glu Asn Phe Thr Ile Lys Ile Ala Asp 
    770                 775                 780                 


Phe Gly Met Ser Arg Asn Leu Tyr Ala Gly Asp Tyr Tyr Arg Val Gln 
785                 790                 795                 800 


Gly Arg Ala Val Leu Pro Ile Arg Trp Met Ala Trp Glu Cys Ile Leu 
                805                 810                 815     


Met Gly Lys Phe Thr Thr Ala Ser Asp Val Trp Ala Phe Gly Val Thr 
            820                 825                 830         


Leu Trp Glu Val Leu Met Leu Cys Arg Ala Gln Pro Phe Gly Gln Leu 
        835                 840                 845             


Thr Asp Glu Gln Val Ile Glu Asn Ala Gly Glu Phe Phe Arg Asp Gln 
    850                 855                 860                 


Gly Arg Gln Val Tyr Leu Ser Arg Pro Pro Ala Cys Pro Gln Gly Leu 
865                 870                 875                 880 


Tyr Glu Leu Met Leu Arg Cys Trp Ser Arg Glu Ser Glu Gln Arg Pro 
                885                 890                 895     


Pro Phe Ser Gln Leu His Arg Phe Leu Ala Glu Asp Ala Leu Asn Thr 
            900                 905                 910         


Val 
    


<210>  3850
<211>  919
<212>  PRT
<213>  Homo sapiens

<400>  3850

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 


Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val 
145                 150                 155                 160 


Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val 
                165                 170                 175     


Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu 
            180                 185                 190         


Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu Ala Val 
        195                 200                 205             


Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Val Gly Gly Leu Gln 
    210                 215                 220                 


Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu Asp Asp 
225                 230                 235                 240 


Phe Arg Lys Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp Tyr Val 
                245                 250                 255     


Gly Trp Ser Asn His Ser Phe Ser Ser Gly Tyr Val Glu Met Glu Phe 
            260                 265                 270         


Glu Phe Asp Arg Leu Arg Ala Phe Gln Ala Met Gln Val His Cys Asn 
        275                 280                 285             


Asn Met His Thr Leu Gly Ala Arg Leu Pro Gly Gly Val Glu Cys Arg 
    290                 295                 300                 


Phe Arg Arg Gly Pro Ala Met Ala Trp Glu Gly Glu Pro Met Arg His 
305                 310                 315                 320 


Asn Leu Gly Gly Asn Leu Gly Asp Pro Arg Ala Arg Ala Val Ser Val 
                325                 330                 335     


Pro Leu Gly Gly Arg Val Ala Arg Phe Leu Gln Cys Arg Phe Leu Phe 
            340                 345                 350         


Ala Gly Pro Trp Leu Leu Phe Ser Glu Ile Ser Phe Ile Ser Asp Val 
        355                 360                 365             


Val Asn Asn Ser Ser Pro Ala Leu Gly Gly Thr Phe Pro Pro Ala Pro 
    370                 375                 380                 


Trp Trp Pro Pro Gly Pro Pro Pro Thr Asn Phe Ser Ser Leu Glu Leu 
385                 390                 395                 400 


Glu Pro Arg Gly Gln Gln Pro Val Ala Lys Ala Glu Gly Ser Pro Thr 
                405                 410                 415     


Ala Ile Leu Ile Gly Cys Leu Val Ala Ile Ile Leu Leu Leu Leu Leu 
            420                 425                 430         


Ile Ile Ala Leu Met Leu Trp Arg Leu His Trp Arg Arg Leu Leu Ser 
        435                 440                 445             


Lys Ala Glu Arg Arg Val Leu Glu Glu Glu Leu Thr Val His Leu Ser 
    450                 455                 460                 


Val Pro Gly Asp Thr Ile Leu Ile Asn Asn Arg Pro Gly Pro Arg Glu 
465                 470                 475                 480 


Pro Pro Pro Tyr Gln Glu Pro Arg Pro Arg Gly Asn Pro Pro His Ser 
                485                 490                 495     


Ala Pro Cys Val Pro Asn Gly Ser Ala Leu Leu Leu Ser Asn Pro Ala 
            500                 505                 510         


Tyr Arg Leu Leu Leu Ala Thr Tyr Ala Arg Pro Pro Arg Gly Pro Gly 
        515                 520                 525             


Pro Pro Thr Pro Ala Trp Ala Lys Pro Thr Asn Thr Gln Ala Tyr Ser 
    530                 535                 540                 


Gly Asp Tyr Met Glu Pro Glu Lys Pro Gly Ala Pro Leu Leu Pro Pro 
545                 550                 555                 560 


Pro Pro Gln Asn Ser Val Pro His Tyr Ala Glu Ala Asp Ile Val Thr 
                565                 570                 575     


Leu Gln Gly Val Thr Gly Gly Asn Thr Tyr Ala Val Pro Ala Leu Pro 
            580                 585                 590         


Pro Gly Ala Val Gly Asp Gly Pro Pro Arg Val Asp Phe Pro Arg Ser 
        595                 600                 605             


Arg Leu Arg Phe Lys Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu Val 
    610                 615                 620                 


His Leu Cys Glu Val Asp Ser Pro Gln Asp Leu Val Ser Leu Asp Phe 
625                 630                 635                 640 


Pro Leu Asn Val Arg Lys Gly His Pro Leu Leu Val Ala Val Lys Ile 
                645                 650                 655     


Leu Arg Pro Asp Ala Thr Lys Asn Ala Ser Phe Ser Leu Phe Ser Arg 
            660                 665                 670         


Asn Asp Phe Leu Lys Glu Val Lys Ile Met Ser Arg Leu Lys Asp Pro 
        675                 680                 685             


Asn Ile Ile Arg Leu Leu Gly Val Cys Val Gln Asp Asp Pro Leu Cys 
    690                 695                 700                 


Met Ile Thr Asp Tyr Met Glu Asn Gly Asp Leu Asn Gln Phe Leu Ser 
705                 710                 715                 720 


Ala His Gln Leu Glu Asp Lys Ala Ala Glu Gly Ala Pro Gly Asp Gly 
                725                 730                 735     


Gln Ala Ala Gln Gly Pro Thr Ile Ser Tyr Pro Met Leu Leu His Val 
            740                 745                 750         


Ala Ala Gln Ile Ala Ser Gly Met Arg Tyr Leu Ala Thr Leu Asn Phe 
        755                 760                 765             


Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Glu Asn Phe 
    770                 775                 780                 


Thr Ile Lys Ile Ala Asp Phe Gly Met Ser Arg Asn Leu Tyr Ala Gly 
785                 790                 795                 800 


Asp Tyr Tyr Arg Val Gln Gly Arg Ala Val Leu Pro Ile Arg Trp Met 
                805                 810                 815     


Ala Trp Glu Cys Ile Leu Met Gly Lys Phe Thr Thr Ala Ser Asp Val 
            820                 825                 830         


Trp Ala Phe Gly Val Thr Leu Trp Glu Val Leu Met Leu Cys Arg Ala 
        835                 840                 845             


Gln Pro Phe Gly Gln Leu Thr Asp Glu Gln Val Ile Glu Asn Ala Gly 
    850                 855                 860                 


Glu Phe Phe Arg Asp Gln Gly Arg Gln Val Tyr Leu Ser Arg Pro Pro 
865                 870                 875                 880 


Ala Cys Pro Gln Gly Leu Tyr Glu Leu Met Leu Arg Cys Trp Ser Arg 
                885                 890                 895     


Glu Ser Glu Gln Arg Pro Pro Phe Ser Gln Leu His Arg Phe Leu Ala 
            900                 905                 910         


Glu Asp Ala Leu Asn Thr Val 
        915                 


<210>  3851
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  3851

Met Val Cys Phe Arg Leu Phe Pro Val Pro Gly Ser Gly Leu Val Leu 
1               5                   10                  15      


Val Cys Leu Val Leu Gly Ala Val Arg Ser Tyr Ala Leu Glu Leu Asn 
            20                  25                  30          


Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln Met 
        35                  40                  45              


Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr Val 
    50                  55                  60                  


Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys Gly 
65                  70                  75                  80  


Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly Phe 
                85                  90                  95      


Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile Asp 
            100                 105                 110         


Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro Asp 
        115                 120                 125             


Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile Arg 
    130                 135                 140                 


Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu Glu 
145                 150                 155                 160 


Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala Phe 
                165                 170                 175     


Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys Asp 
            180                 185                 190         


Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser Pro 
        195                 200                 205             


Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr Ser 
    210                 215                 220                 


Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu Gln 
225                 230                 235                 240 


Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn Pro 
                245                 250                 255     


Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu Leu 
            260                 265                 270         


Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala Val 
        275                 280                 285             


Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met Tyr 
    290                 295                 300                 


Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser Tyr 
305                 310                 315                 320 


Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln Thr 
                325                 330                 335     


Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg Val 
            340                 345                 350         


Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Glu Cys 
        355                 360                 365             


Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile Val Gly Ala Gly 
    370                 375                 380                 


Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Tyr Val Ile Gly Arg 
385                 390                 395                 400 


Arg Lys Ser Tyr Ala Gly Tyr Gln Thr Leu 
                405                 410 


<210>  3852
<211>  842
<212>  PRT
<213>  Homo sapiens

<400>  3852

Met Leu Tyr Ser Ser Arg Gly Asp Pro Glu Gly Gln Pro Leu Leu Leu 
1               5                   10                  15      


Ser Leu Leu Ile Leu Ala Met Trp Val Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Glu His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Gln Leu Asp Ser Lys Gly Arg Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Pro Ala Thr Gln Lys Asn Leu Phe Ile Ala Glu 
    130                 135                 140                 


Ser Arg Pro Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Glu Asn Ala Leu Leu Thr Tyr Arg Leu Ser Pro Asn Glu 
                165                 170                 175     


Tyr Phe Phe Leu Asp Val Pro Thr Ser Asn Gln Gln Val Lys Pro Leu 
            180                 185                 190         


Gly Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Glu Thr Pro Glu Leu 
        195                 200                 205             


His Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Ile Thr Val Leu Asp Asn Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Val Phe Asp Arg Thr Leu Tyr Thr Val Lys Leu Pro Glu Asn Val Ser 
                245                 250                 255     


Ile Gly Thr Leu Val Ile His Pro Asn Ala Ser Asp Leu Asp Glu Gly 
            260                 265                 270         


Leu Asn Gly Asp Ile Ile Tyr Ser Phe Ser Ser Asp Val Ser Pro Asp 
        275                 280                 285             


Ile Lys Ser Lys Phe His Met Asp Pro Leu Ser Gly Ala Ile Thr Val 
    290                 295                 300                 


Ile Gly His Met Asp Phe Glu Glu Ser Arg Ala His Lys Ile Pro Val 
305                 310                 315                 320 


Glu Ala Val Asp Lys Gly Phe Pro Pro Leu Ala Gly His Cys Thr Leu 
                325                 330                 335     


Leu Val Glu Val Val Asp Val Asn Asp Asn Ala Pro Gln Leu Thr Ile 
            340                 345                 350         


Lys Thr Leu Ser Val Pro Val Lys Glu Asp Ala Gln Leu Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Ile Asp Leu Asp Ala Asp Ala Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Tyr Lys Asn Tyr Tyr Ser Leu Val Leu Asp Arg Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Arg Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Ser Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Leu Gly Glu Arg Ser Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Thr Pro Arg Met Arg Gly Thr Asp Gly Ala 
                565                 570                 575     


Val Ser Glu Met Val Leu Arg Ser Val Gly Ala Gly Val Val Val Gly 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Glu Thr Ala Ser Ala Ser Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr 
625                 630                 635                 640 


Asp Ala Pro Arg Gln Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ser Ser Ser Arg Ala Ser Val Gly Ala Thr Gly 
        675                 680                 685             


Pro Glu Val Thr Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Val 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Met Pro Thr Glu Gly Glu Cys Ala Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Gln Arg Val Cys Ser Gly Glu Gly Lys Gln Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Gly Leu Ser Pro Cys Ala Gly Ser Thr Glu 
    770                 775                 780                 


Arg Thr Gly Glu Pro Ser Ala Ser Ser Asp Ser Thr Gly Lys Val Gly 
785                 790                 795                 800 


Phe Ser Ser Ile Leu Phe Ile Tyr Ile Ile Phe Phe Leu Glu Arg Tyr 
                805                 810                 815     


Tyr Arg Leu Leu Pro Gly Ala Val Gln Ile Val Leu Phe Ile Phe Leu 
            820                 825                 830         


Glu Ile Gln Gln Ile Phe Phe Leu Ile Lys 
        835                 840         


<210>  3853
<211>  1288
<212>  PRT
<213>  Homo sapiens

<400>  3853

Met Ala Ala Ala Gly Ala Arg Leu Ser Pro Gly Pro Gly Ser Gly Leu 
1               5                   10                  15      


Arg Gly Arg Pro Arg Leu Cys Phe His Pro Gly Pro Pro Pro Leu Leu 
            20                  25                  30          


Pro Leu Leu Leu Leu Phe Leu Leu Leu Leu Pro Pro Pro Pro Leu Leu 
        35                  40                  45              


Ala Gly Ala Thr Ala Ala Ala Ser Arg Glu Pro Asp Ser Pro Cys Arg 
    50                  55                  60                  


Leu Lys Thr Val Thr Val Ser Thr Leu Pro Ala Leu Arg Glu Ser Asp 
65                  70                  75                  80  


Ile Gly Trp Ser Gly Ala Arg Ala Gly Ala Gly Ala Gly Thr Gly Ala 
                85                  90                  95      


Gly Ala Ala Ala Ala Ala Ala Ser Pro Gly Ser Pro Gly Ser Ala Gly 
            100                 105                 110         


Thr Ala Ala Glu Ser Arg Leu Leu Leu Phe Val Arg Asn Glu Leu Pro 
        115                 120                 125             


Gly Arg Ile Ala Val Gln Asp Asp Leu Asp Asn Thr Glu Leu Pro Phe 
    130                 135                 140                 


Phe Thr Leu Glu Met Ser Gly Thr Ala Ala Asp Ile Ser Leu Val His 
145                 150                 155                 160 


Trp Arg Gln Gln Trp Leu Glu Asn Gly Thr Leu Tyr Phe His Val Ser 
                165                 170                 175     


Met Ser Ser Ser Gly Gln Leu Ala Gln Ala Thr Ala Pro Thr Leu Gln 
            180                 185                 190         


Glu Pro Ser Glu Ile Val Glu Glu Gln Met His Ile Leu His Ile Ser 
        195                 200                 205             


Val Met Gly Gly Leu Ile Ala Leu Leu Leu Leu Leu Leu Val Phe Thr 
    210                 215                 220                 


Val Ala Leu Tyr Ala Gln Arg Arg Trp Gln Lys Arg Arg Arg Ile Pro 
225                 230                 235                 240 


Gln Lys Ser Ala Ser Thr Glu Ala Thr His Glu Ile His Tyr Ile Pro 
                245                 250                 255     


Ser Val Leu Leu Gly Pro Gln Ala Arg Glu Ser Phe Arg Ser Ser Arg 
            260                 265                 270         


Leu Gln Thr His Asn Ser Val Ile Gly Val Pro Ile Arg Glu Thr Pro 
        275                 280                 285             


Ile Leu Asp Asp Tyr Asp Cys Glu Glu Asp Glu Glu Pro Pro Arg Arg 
    290                 295                 300                 


Ala Asn His Val Ser Arg Glu Asp Glu Phe Gly Ser Gln Val Thr His 
305                 310                 315                 320 


Thr Leu Asp Ser Leu Gly His Pro Gly Glu Glu Lys Val Asp Phe Glu 
                325                 330                 335     


Lys Lys Gly Gly Ile Ser Phe Gly Arg Ala Lys Gly Thr Ser Gly Ser 
            340                 345                 350         


Glu Ala Asp Asp Glu Thr Gln Leu Thr Phe Tyr Thr Glu Gln Tyr Arg 
        355                 360                 365             


Ser Arg Arg Arg Ser Lys Gly Leu Leu Lys Ser Pro Val Asn Lys Thr 
    370                 375                 380                 


Ala Leu Thr Leu Ile Ala Val Ser Ser Cys Ile Leu Ala Met Val Cys 
385                 390                 395                 400 


Gly Ser Gln Met Ser Cys Pro Leu Thr Val Lys Val Thr Leu His Val 
                405                 410                 415     


Pro Glu His Phe Ile Ala Asp Gly Ser Ser Phe Val Val Ser Glu Gly 
            420                 425                 430         


Ser Tyr Leu Asp Ile Ser Asp Trp Leu Asn Pro Ala Lys Leu Ser Leu 
        435                 440                 445             


Tyr Tyr Gln Ile Asn Ala Thr Ser Pro Trp Val Arg Asp Leu Cys Gly 
    450                 455                 460                 


Gln Arg Thr Thr Asp Ala Cys Glu Gln Leu Cys Asp Pro Glu Thr Gly 
465                 470                 475                 480 


Glu Cys Ser Cys His Glu Gly Tyr Ala Pro Asp Pro Val His Arg His 
                485                 490                 495     


Leu Cys Val Arg Ser Asp Trp Gly Gln Ser Glu Gly Pro Trp Pro Tyr 
            500                 505                 510         


Thr Thr Leu Glu Arg Gly Tyr Asp Leu Val Thr Gly Glu Gln Ala Pro 
        515                 520                 525             


Glu Lys Ile Leu Arg Ser Thr Phe Ser Leu Gly Gln Gly Leu Trp Leu 
    530                 535                 540                 


Pro Val Ser Lys Ser Phe Val Val Pro Pro Val Glu Leu Ser Ile Asn 
545                 550                 555                 560 


Pro Leu Ala Ser Cys Lys Thr Asp Val Leu Val Thr Glu Asp Pro Ala 
                565                 570                 575     


Asp Val Arg Glu Glu Ala Met Leu Ser Thr Tyr Phe Glu Thr Ile Asn 
            580                 585                 590         


Asp Leu Leu Ser Ser Phe Gly Pro Val Arg Asp Cys Ser Arg Asn Asn 
        595                 600                 605             


Gly Gly Cys Thr Arg Asn Phe Lys Cys Val Ser Asp Arg Gln Val Asp 
    610                 615                 620                 


Ser Ser Gly Cys Val Cys Pro Glu Glu Leu Lys Pro Met Lys Asp Gly 
625                 630                 635                 640 


Ser Gly Cys Tyr Asp His Ser Lys Gly Ile Asp Cys Ser Asp Gly Phe 
                645                 650                 655     


Asn Gly Gly Cys Glu Gln Leu Cys Leu Gln Gln Thr Leu Pro Leu Pro 
            660                 665                 670         


Tyr Asp Ala Thr Ser Ser Thr Ile Phe Met Phe Cys Gly Cys Val Glu 
        675                 680                 685             


Glu Tyr Lys Leu Ala Pro Asp Gly Lys Ser Cys Leu Met Leu Ser Asp 
    690                 695                 700                 


Val Cys Glu Gly Pro Lys Cys Leu Lys Pro Asp Ser Lys Phe Asn Asp 
705                 710                 715                 720 


Thr Leu Phe Gly Glu Met Leu His Gly Tyr Asn Asn Arg Thr Gln His 
                725                 730                 735     


Val Asn Gln Gly Gln Val Phe Gln Met Thr Phe Arg Glu Asn Asn Phe 
            740                 745                 750         


Ile Lys Asp Phe Pro Gln Leu Ala Asp Gly Leu Leu Val Ile Pro Leu 
        755                 760                 765             


Pro Val Glu Glu Gln Cys Arg Gly Val Leu Ser Glu Pro Leu Pro Asp 
    770                 775                 780                 


Leu Gln Leu Leu Thr Gly Asp Ile Arg Tyr Asp Glu Ala Met Gly Tyr 
785                 790                 795                 800 


Pro Met Val Gln Gln Trp Arg Val Arg Ser Asn Leu Tyr Arg Val Lys 
                805                 810                 815     


Leu Ser Thr Ile Thr Leu Ala Ala Gly Phe Thr Asn Val Leu Lys Ile 
            820                 825                 830         


Leu Thr Lys Glu Ser Ser Arg Glu Glu Leu Leu Ser Phe Ile Gln His 
        835                 840                 845             


Tyr Gly Ser His Tyr Ile Ala Glu Ala Leu Tyr Gly Ser Glu Leu Thr 
    850                 855                 860                 


Cys Ile Ile His Phe Pro Ser Lys Lys Val Gln Gln Gln Leu Trp Leu 
865                 870                 875                 880 


Gln Tyr Gln Lys Glu Thr Thr Glu Leu Gly Ser Lys Lys Glu Leu Lys 
                885                 890                 895     


Ser Met Pro Phe Ile Thr Tyr Leu Ser Gly Leu Leu Thr Ala Gln Met 
            900                 905                 910         


Leu Ser Asp Asp Gln Leu Ile Ser Gly Val Glu Ile Arg Cys Glu Glu 
        915                 920                 925             


Lys Gly Arg Cys Pro Ser Thr Cys His Leu Cys Arg Arg Pro Gly Lys 
    930                 935                 940                 


Glu Gln Leu Ser Pro Thr Pro Val Leu Leu Glu Ile Asn Arg Val Val 
945                 950                 955                 960 


Pro Leu Tyr Thr Leu Ile Gln Asp Asn Gly Thr Lys Glu Ala Phe Lys 
                965                 970                 975     


Ser Ala Leu Met Ser Ser Tyr Trp Cys Ser Gly Lys Gly Asp Val Ile 
            980                 985                 990         


Asp Asp Trp Cys Arg Cys Asp Leu  Ser Ala Phe Asp Ala  Asn Gly Leu 
        995                 1000                 1005             


Pro Asn  Cys Ser Pro Leu Leu  Gln Pro Val Leu Arg  Leu Ser Pro 
    1010                 1015                 1020             


Thr Val  Glu Pro Ser Ser Thr  Val Val Ser Leu Glu  Trp Val Asp 
    1025                 1030                 1035             


Val Gln  Pro Ala Ile Gly Thr  Lys Val Ser Asp Tyr  Ile Leu Gln 
    1040                 1045                 1050             


His Lys  Lys Val Asp Glu Tyr  Thr Asp Thr Asp Leu  Tyr Thr Gly 
    1055                 1060                 1065             


Glu Phe  Leu Ser Phe Ala Asp  Asp Leu Leu Ser Gly  Leu Gly Thr 
    1070                 1075                 1080             


Ser Cys  Val Ala Ala Gly Arg  Ser His Gly Glu Val  Pro Glu Val 
    1085                 1090                 1095             


Ser Ile  Tyr Ser Val Ile Phe  Lys Cys Leu Glu Pro  Asp Gly Leu 
    1100                 1105                 1110             


Tyr Lys  Phe Thr Leu Tyr Ala  Val Asp Thr Arg Gly  Arg His Ser 
    1115                 1120                 1125             


Glu Leu  Ser Thr Val Thr Leu  Arg Thr Ala Cys Pro  Leu Val Asp 
    1130                 1135                 1140             


Asp Asn  Lys Ala Glu Glu Ile  Ala Asp Lys Ile Tyr  Asn Leu Tyr 
    1145                 1150                 1155             


Asn Gly  Tyr Thr Ser Gly Lys  Glu Gln Gln Met Ala  Tyr Asn Thr 
    1160                 1165                 1170             


Leu Met  Glu Val Ser Ala Ser  Met Leu Phe Arg Val  Gln His His 
    1175                 1180                 1185             


Tyr Asn  Ser His Tyr Glu Lys  Phe Gly Asp Phe Val  Trp Arg Ser 
    1190                 1195                 1200             


Glu Asp  Glu Leu Gly Pro Arg  Lys Ala His Leu Ile  Leu Arg Arg 
    1205                 1210                 1215             


Leu Glu  Arg Val Ser Ser His  Cys Ser Ser Leu Leu  Arg Ser Ala 
    1220                 1225                 1230             


Tyr Ile  Gln Ser Arg Val Glu  Thr Val Pro Tyr Leu  Phe Cys Arg 
    1235                 1240                 1245             


Ser Glu  Glu Val Arg Pro Ala  Gly Met Val Trp Tyr  Ser Ile Leu 
    1250                 1255                 1260             


Lys Asp  Thr Lys Ile Thr Cys  Glu Glu Lys Met Val  Ser Met Ala 
    1265                 1270                 1275             


Arg Asn  Thr Tyr Gly Glu Ser  Lys Gly Arg 
    1280                 1285             


<210>  3854
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  3854

Met Leu Gly Ala Arg Val Ala Ala His Leu Asp Ala Leu Gly Pro Leu 
1               5                   10                  15      


Val Pro Tyr Val Pro Pro Pro Leu Leu Pro Ser Met Phe Tyr Val Gly 
            20                  25                  30          


Leu Phe Phe Val Asn Val Leu Ile Leu Tyr Tyr Ala Phe Leu Met Glu 
        35                  40                  45              


Tyr Ile Val Leu Asn Val Gly Leu Val Phe Leu Pro Glu Asp Met Asp 
    50                  55                  60                  


Gln Ala Leu Val Asp Leu Gly Val Leu Ser Asp Pro Gly Ser Gly Leu 
65                  70                  75                  80  


Tyr Asp Ala Asp Ser Glu Leu Asp Val Phe Asp Ala Tyr Leu Glu 
                85                  90                  95  


<210>  3855
<211>  587
<212>  PRT
<213>  Homo sapiens

<400>  3855

Met Ala Thr Ala Ala Tyr Glu Gln Leu Lys Leu His Ile Thr Pro Glu 
1               5                   10                  15      


Lys Phe Tyr Val Glu Ala Cys Asp Asp Gly Ala Asp Asp Val Leu Thr 
            20                  25                  30          


Ile Asp Arg Val Ser Thr Glu Val Thr Leu Ala Val Lys Lys Asp Val 
        35                  40                  45              


Pro Pro Ser Ala Val Thr Arg Pro Ile Phe Gly Ile Leu Gly Thr Ile 
    50                  55                  60                  


His Leu Val Ala Gly Asn Tyr Leu Ile Val Ile Thr Lys Lys Ile Lys 
65                  70                  75                  80  


Val Gly Glu Phe Phe Ser His Val Val Trp Lys Ala Thr Asp Phe Asp 
                85                  90                  95      


Val Leu Ser Tyr Lys Lys Thr Met Leu His Leu Thr Asp Ile Gln Leu 
            100                 105                 110         


Gln Asp Asn Lys Thr Phe Leu Ala Met Leu Asn His Val Leu Asn Val 
        115                 120                 125             


Asp Gly Phe Tyr Phe Ser Thr Thr Tyr Asp Leu Thr His Thr Leu Gln 
    130                 135                 140                 


Arg Leu Ser Asn Thr Ser Pro Glu Phe Gln Glu Met Ser Leu Leu Glu 
145                 150                 155                 160 


Arg Ala Asp Gln Arg Phe Val Trp Asn Gly His Leu Leu Arg Glu Leu 
                165                 170                 175     


Ser Ala Gln Pro Glu Val His Arg Phe Ala Leu Pro Val Leu His Gly 
            180                 185                 190         


Phe Ile Thr Met His Ser Cys Ser Ile Asn Gly Lys Tyr Phe Asp Trp 
        195                 200                 205             


Ile Leu Ile Ser Arg Arg Ser Cys Phe Arg Ala Gly Val Arg Tyr Tyr 
    210                 215                 220                 


Val Arg Gly Ile Asp Ser Glu Gly His Ala Ala Asn Phe Val Glu Thr 
225                 230                 235                 240 


Glu Gln Ile Val His Tyr Asn Gly Ser Lys Ala Ser Phe Val Gln Thr 
                245                 250                 255     


Arg Gly Ser Ile Pro Val Phe Trp Ser Gln Arg Pro Asn Leu Lys Tyr 
            260                 265                 270         


Lys Pro Leu Pro Gln Ile Ser Lys Val Ala Asn His Met Asp Gly Phe 
        275                 280                 285             


Gln Arg His Phe Asp Ser Gln Val Ile Ile Tyr Gly Lys Gln Val Ile 
    290                 295                 300                 


Ile Asn Leu Ile Asn Gln Lys Gly Ser Glu Lys Pro Leu Glu Gln Thr 
305                 310                 315                 320 


Phe Ala Thr Met Val Ser Ser Leu Gly Ser Gly Met Met Arg Tyr Ile 
                325                 330                 335     


Ala Phe Asp Phe His Lys Glu Cys Lys Asn Met Arg Trp Asp Arg Leu 
            340                 345                 350         


Ser Ile Leu Leu Asp Gln Val Ala Glu Met Gln Asp Glu Leu Ser Tyr 
        355                 360                 365             


Phe Leu Val Asp Ser Ala Gly Gln Val Val Ala Asn Gln Glu Gly Val 
    370                 375                 380                 


Phe Arg Ser Asn Cys Met Asp Cys Leu Asp Arg Thr Asn Val Ile Gln 
385                 390                 395                 400 


Ser Leu Leu Ala Arg Arg Ser Leu Gln Ala Gln Leu Gln Arg Leu Gly 
                405                 410                 415     


Val Leu His Val Gly Gln Lys Leu Glu Glu Gln Asp Glu Phe Glu Lys 
            420                 425                 430         


Ile Tyr Lys Asn Ala Trp Ala Asp Asn Ala Asn Ala Cys Ala Lys Gln 
        435                 440                 445             


Tyr Ala Gly Thr Gly Ala Leu Lys Thr Asp Phe Thr Arg Thr Gly Lys 
    450                 455                 460                 


Arg Thr His Leu Gly Leu Ile Met Asp Gly Trp Asn Ser Met Ile Arg 
465                 470                 475                 480 


Tyr Tyr Lys Asn Asn Phe Ser Asp Gly Phe Arg Gln Asp Ser Ile Asp 
                485                 490                 495     


Leu Phe Leu Gly Asn Tyr Ser Val Asp Glu Leu Glu Ser His Ser Pro 
            500                 505                 510         


Leu Ser Val Pro Arg Asp Trp Lys Phe Leu Ala Leu Pro Ile Ile Met 
        515                 520                 525             


Val Val Ala Phe Ser Met Cys Ile Ile Cys Leu Leu Met Ala Gly Asp 
    530                 535                 540                 


Thr Trp Thr Glu Thr Leu Ala Tyr Val Leu Phe Trp Gly Val Ala Ser 
545                 550                 555                 560 


Ile Gly Thr Phe Phe Ile Ile Leu Tyr Asn Gly Lys Asp Phe Val Asp 
                565                 570                 575     


Ala Pro Arg Leu Val Gln Lys Glu Lys Ile Asp 
            580                 585         


<210>  3856
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  3856

Met Thr Gln Asn Thr Val Ile Val Asn Gly Val Ala Met Ala Ser Arg 
1               5                   10                  15      


Pro Ser Gln Pro Thr His Val Asn Val His Ile His Gln Glu Ser Ala 
            20                  25                  30          


Leu Thr Gln Leu Leu Lys Ala Gly Gly Ser Leu Lys Lys Phe Leu Phe 
        35                  40                  45              


His Pro Gly Asp Thr Val Pro Ser Thr Ala Arg Ile Gly Tyr Glu Gln 
    50                  55                  60                  


Leu Ala Leu Gly Val Thr Gln Ile Leu Leu Gly Val Val Ser Cys Val 
65                  70                  75                  80  


Leu Gly Val Cys Leu Ser Leu Gly Pro Trp Thr Val Leu Ser Ala Ser 
                85                  90                  95      


Gly Cys Ala Phe Trp Ala Gly Ser Val Val Ile Ala Ala Gly Ala Gly 
            100                 105                 110         


Ala Ile Val His Glu Lys His Pro Gly Lys Leu Ala Gly Tyr Ile Ser 
        115                 120                 125             


Ser Leu Leu Thr Leu Ala Gly Phe Ala Thr Ala Met Ala Ala Val Val 
    130                 135                 140                 


Leu Cys Val Asn Ser Phe Ile Trp Gln Thr Glu Pro Phe Leu Tyr Ile 
145                 150                 155                 160 


Asp Thr Val Cys Asp Arg Ser Asp Pro Val Phe Pro Thr Thr Gly Tyr 
                165                 170                 175     


Arg Trp Met Arg Arg Ser Gln Glu Asn Gln Trp Gln Lys Glu Glu Cys 
            180                 185                 190         


Arg Ala Tyr Met Gln Met Leu Arg Lys Leu Phe Thr Ala Ile Arg Ala 
        195                 200                 205             


Leu Phe Leu Ala Val Cys Val Leu Lys Val Ile Val Ser Leu Val Ser 
    210                 215                 220                 


Leu Gly Val Gly Leu Arg Asn Leu Cys Gly Gln Ser Ser Gln Pro Leu 
225                 230                 235                 240 


Asn Glu Glu Gly Ser Glu Lys Arg Leu Leu Gly Glu Asn Ser Val Pro 
                245                 250                 255     


Pro Ser Pro Ser Arg Glu Gln Thr Ser Thr Ala Ile Val Leu 
            260                 265                 270 


<210>  3857
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  3857

Met Glu Pro Gly Pro Thr Ala Ala Gln Arg Arg Cys Ser Leu Pro Pro 
1               5                   10                  15      


Trp Leu Pro Leu Gly Leu Leu Leu Trp Ser Gly Leu Ala Leu Gly Ala 
            20                  25                  30          


Leu Pro Phe Gly Ser Ser Pro His Arg Val Phe His Asp Leu Leu Ser 
        35                  40                  45              


Glu Gln Gln Leu Leu Glu Val Glu Asp Leu Ser Leu Ser Leu Leu Gln 
    50                  55                  60                  


Gly Gly Gly Leu Gly Pro Leu Ser Leu Pro Pro Asp Leu Pro Asp Leu 
65                  70                  75                  80  


Asp Pro Glu Cys Arg Glu Leu Leu Leu Asp Phe Ala Asn Ser Ser Ala 
                85                  90                  95      


Glu Leu Thr Gly Cys Leu Val Arg Ser Ala Arg Pro Val Arg Leu Cys 
            100                 105                 110         


Gln Thr Cys Tyr Pro Leu Phe Gln Gln Val Val Ser Lys Met Asp Asn 
        115                 120                 125             


Ile Ser Arg Ala Ala Gly Asn Thr Ser Glu Ser Gln Ser Cys Ala Arg 
    130                 135                 140                 


Ser Leu Leu Met Ala Asp Arg Met Gln Ile Val Val Ile Leu Ser Glu 
145                 150                 155                 160 


Phe Phe Asn Thr Thr Trp Gln Glu Ala Asn Cys Ala Asn Cys Leu Thr 
                165                 170                 175     


Asn Asn Ser Glu Glu Leu Ser Asn Ser Thr Val Tyr Phe Leu Asn Leu 
            180                 185                 190         


Phe Asn His Thr Leu Thr Cys Phe Glu His Asn Leu Gln Gly Asn Ala 
        195                 200                 205             


His Ser Leu Leu Gln Thr Lys Asn Tyr Ser Glu Val Cys Lys Asn Cys 
    210                 215                 220                 


Arg Glu Ala Tyr Lys Thr Leu Ser Ser Leu Tyr Ser Glu Met Gln Lys 
225                 230                 235                 240 


Met Asn Glu Leu Glu Asn Lys Ala Glu Pro Gly Thr His Leu Cys Ile 
                245                 250                 255     


Asp Val Glu Asp Ala Met Asn Ile Thr Arg Lys Leu Trp Ser Arg Thr 
            260                 265                 270         


Phe Asn Cys Ser Val Pro Cys Ser Asp Thr Val Pro Val Ile Ala Val 
        275                 280                 285             


Ser Val Phe Ile Leu Phe Leu Pro Val Val Phe Tyr Leu Ser Ser Phe 
    290                 295                 300                 


Leu His Ser Glu Gln Lys Lys Arg Lys Leu Ile Leu Pro Lys Arg Leu 
305                 310                 315                 320 


Lys Ser Ser Thr Ser Phe Ala Asn Ile Gln Glu Asn Ser Asn 
                325                 330                 


<210>  3858
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  3858

Met Glu Leu Thr Ile Phe Ile Leu Arg Leu Ala Ile Tyr Ile Leu Thr 
1               5                   10                  15      


Phe Pro Leu Tyr Leu Leu Asn Phe Leu Gly Leu Trp Ser Trp Ile Cys 
            20                  25                  30          


Lys Lys Trp Phe Pro Tyr Phe Leu Val Arg Phe Thr Val Ile Tyr Asn 
        35                  40                  45              


Glu Gln Met Ala Ser Lys Lys Arg Glu Leu Phe Ser Asn Leu Gln Glu 
    50                  55                  60                  


Phe Ala Gly Pro Ser Gly Lys Leu Ser Leu Leu Glu Val Gly Cys Gly 
65                  70                  75                  80  


Thr Gly Ala Asn Phe Lys Phe Tyr Pro Pro Gly Cys Arg Val Thr Cys 
                85                  90                  95      


Ile Asp Pro Asn Pro Asn Phe Glu Lys Phe Leu Ile Lys Ser Ile Ala 
            100                 105                 110         


Glu Asn Arg His Leu Gln Phe Glu Arg Phe Val Val Ala Ala Gly Glu 
        115                 120                 125             


Asn Met His Gln Val Ala Asp Gly Ser Val Asp Val Val Val Cys Thr 
    130                 135                 140                 


Leu Val Leu Cys Ser Val Lys Asn Gln Glu Arg Ile Leu Arg Glu Val 
145                 150                 155                 160 


Cys Arg Val Leu Arg Pro Gly Gly Ala Phe Tyr Phe Met Glu His Val 
                165                 170                 175     


Ala Ala Glu Cys Ser Thr Trp Asn Tyr Phe Trp Gln Gln Val Leu Asp 
            180                 185                 190         


Pro Ala Trp His Leu Leu Phe Asp Gly Cys Asn Leu Thr Arg Glu Ser 
        195                 200                 205             


Trp Lys Ala Leu Glu Arg Ala Ser Phe Ser Lys Leu Lys Leu Gln His 
    210                 215                 220                 


Ile Gln Ala Pro Leu Ser Trp Glu Leu Val Arg Pro His Ile Tyr Gly 
225                 230                 235                 240 


Tyr Ala Val Lys 
                


<210>  3859
<211>  736
<212>  PRT
<213>  Homo sapiens

<400>  3859

Met Lys Thr Glu Ala Gln Pro Ser Thr Ser Leu Leu Ala Asn Thr Ser 
1               5                   10                  15      


Trp Thr Gly Thr Val Ile Ser Asp Ser Val Pro Gly Ser Gln Thr Trp 
            20                  25                  30          


Glu Asp Lys Gly Ser Leu Thr Arg Ser Ala Thr Ser Trp Thr Ser Glu 
        35                  40                  45              


Ala Gln Val Ser Ala Ala Arg Val Ala Glu Ala Gln Ala Arg Thr Ser 
    50                  55                  60                  


Gln Pro Lys Gln Ile Ser Val Leu Glu Ala Leu Thr Ala Ser Ala Leu 
65                  70                  75                  80  


Asn Gln Lys Pro Thr His Glu Lys Val Gln Met Thr Glu Lys Lys Glu 
                85                  90                  95      


Ser Glu Val Leu Leu Ala Arg Pro Phe Trp Ser Ser Lys Thr Glu Tyr 
            100                 105                 110         


Ile Leu Ala Gln Val Gly Phe Ser Met Lys Pro Ser Cys Leu Trp Arg 
        115                 120                 125             


Phe Ala Tyr Leu Trp Leu Asn Ser Gly Gly Cys Ser Phe Ala Ala Ile 
    130                 135                 140                 


Tyr Ile Phe Met Leu Phe Leu Val Gly Val Pro Leu Leu Phe Leu Glu 
145                 150                 155                 160 


Met Ala Ala Gly Gln Ser Met Arg Gln Gly Gly Met Gly Val Trp Lys 
                165                 170                 175     


Ile Ile Ala Pro Trp Ile Gly Gly Val Gly Tyr Ser Ser Phe Met Val 
            180                 185                 190         


Cys Phe Ile Leu Gly Leu Tyr Phe Asn Val Val Asn Ser Trp Ile Ile 
        195                 200                 205             


Phe Tyr Met Ser Gln Ser Phe Gln Phe Pro Val Pro Trp Glu Lys Cys 
    210                 215                 220                 


Pro Leu Thr Met Asn Ser Ser Gly Phe Asp Pro Glu Cys Glu Arg Thr 
225                 230                 235                 240 


Thr Pro Ser Ile Tyr Phe Trp Tyr Gln Gln Ala Leu Lys Ala Ser Asp 
                245                 250                 255     


Arg Ile Glu Asp Gly Gly Ser Pro Val Tyr Ser Leu Val Leu Pro Phe 
            260                 265                 270         


Phe Leu Cys Trp Cys Leu Val Gly Ala Phe Met Ile Asn Gly Leu Lys 
        275                 280                 285             


Ser Thr Gly Lys Val Ile Tyr Val Leu Val Leu Leu Pro Cys Phe Ile 
    290                 295                 300                 


Ile Val Gly Phe Phe Ile Arg Thr Leu Leu Leu Glu Gly Ala Lys Phe 
305                 310                 315                 320 


Gly Leu Gln Gln Leu Val Val Ala Lys Ile Ser Asp Val Tyr Asn Met 
                325                 330                 335     


Ser Val Trp Ser Leu Ala Gly Gly Gln Val Leu Ser Asn Thr Gly Ile 
            340                 345                 350         


Gly Leu Gly Ser Val Ala Ser Leu Ala Ser Tyr Met Pro Gln Ser Asn 
        355                 360                 365             


Asn Cys Leu Ser Asp Ala Phe Leu Val Ser Val Ile Asn Leu Leu Thr 
    370                 375                 380                 


Leu Leu Val Phe Thr Ser Phe Asn Phe Cys Val Leu Gly Phe Trp Ala 
385                 390                 395                 400 


Thr Val Ile Thr His Arg Cys Cys Glu Arg Asn Ala Glu Ile Leu Leu 
                405                 410                 415     


Lys Leu Ile Asn Leu Gly Lys Leu Pro Pro Asp Ala Lys Pro Pro Val 
            420                 425                 430         


Asn Leu Leu Tyr Asn Pro Thr Ser Ile Tyr Asn Ala Trp Leu Ser Gly 
        435                 440                 445             


Leu Pro Gln His Ile Lys Ser Met Val Leu Arg Glu Val Thr Glu Cys 
    450                 455                 460                 


Asn Ile Glu Thr Gln Phe Leu Lys Ala Ser Glu Gly Pro Lys Phe Ala 
465                 470                 475                 480 


Phe Leu Ser Phe Val Glu Ala Met Ser Phe Leu Pro Pro Ser Val Phe 
                485                 490                 495     


Trp Ser Phe Ile Phe Phe Leu Met Leu Leu Ala Met Gly Leu Ser Ser 
            500                 505                 510         


Ala Ile Gly Ile Met Gln Gly Ile Ile Thr Pro Leu Gln Asp Thr Phe 
        515                 520                 525             


Ser Phe Phe Arg Lys His Thr Lys Leu Leu Ile Val Gly Val Phe Leu 
    530                 535                 540                 


Leu Met Phe Val Cys Gly Leu Phe Phe Thr Arg Pro Ser Gly Ser Tyr 
545                 550                 555                 560 


Phe Ile Arg Leu Leu Ser Asp Tyr Trp Ile Val Phe Pro Ile Ile Val 
                565                 570                 575     


Val Val Val Phe Glu Thr Met Ala Val Ser Trp Ala Tyr Gly Ala Arg 
            580                 585                 590         


Arg Phe Leu Ala Asp Leu Thr Ile Leu Leu Gly His Pro Ile Ser Pro 
        595                 600                 605             


Ile Phe Gly Trp Leu Trp Pro His Leu Cys Pro Val Val Leu Leu Ile 
    610                 615                 620                 


Ile Phe Val Thr Met Met Val His Leu Cys Met Lys Pro Ile Thr Tyr 
625                 630                 635                 640 


Met Ser Trp Asp Ser Ser Thr Ser Lys Glu Val Leu Arg Pro Tyr Pro 
                645                 650                 655     


Pro Trp Ala Leu Leu Leu Met Ile Thr Leu Phe Ala Ile Val Ile Leu 
            660                 665                 670         


Pro Ile Pro Ala Tyr Phe Val Tyr Cys Arg Ile His Arg Ile Pro Phe 
        675                 680                 685             


Arg Pro Lys Ser Gly Asp Gly Pro Met Thr Ala Ser Thr Ser Leu Pro 
    690                 695                 700                 


Leu Ser His Gln Leu Thr Pro Ser Lys Glu Val Gln Lys Glu Glu Ile 
705                 710                 715                 720 


Leu Gln Val Asp Glu Thr Lys Tyr Pro Ser Thr Cys Asn Val Thr Ser 
                725                 730                 735     


<210>  3860
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  3860

Met Ala Arg Gly Gly Asp Thr Gly Cys Thr Gly Pro Ser Glu Thr Ser 
1               5                   10                  15      


Ala Ser Gly Ala Ala Ala Ile Ala Leu Pro Gly Leu Glu Gly Pro Ala 
            20                  25                  30          


Thr Asp Ala Gln Cys Gln Thr Leu Pro Leu Thr Val Leu Lys Ser Arg 
        35                  40                  45              


Ser Pro Ser Pro Arg Ser Leu Pro Pro Ala Leu Ser Cys Pro Pro Pro 
    50                  55                  60                  


Gln Pro Ala Met Leu Glu His Leu Ser Ser Leu Pro Thr Gln Met Asp 
65                  70                  75                  80  


Tyr Lys Gly Gln Lys Leu Ala Glu Gln Met Phe Gln Gly Ile Ile Leu 
                85                  90                  95      


Phe Ser Ala Ile Val Gly Phe Ile Tyr Gly Tyr Val Ala Glu Gln Phe 
            100                 105                 110         


Gly Trp Thr Val Tyr Ile Val Met Ala Gly Phe Ala Phe Ser Cys Leu 
        115                 120                 125             


Leu Thr Leu Pro Pro Trp Pro Ile Tyr Arg Arg His Pro Leu Lys Trp 
    130                 135                 140                 


Leu Pro Val Gln Glu Ser Ser Thr Asp Asp Lys Lys Pro Gly Glu Arg 
145                 150                 155                 160 


Lys Ile Lys Arg His Ala Lys Asn Asn 
                165                 


<210>  3861
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  3861

Met Leu Pro Ser Thr Ser Val Asn Ser Leu Val Gln Gly Asn Gly Val 
1               5                   10                  15      


Leu Asn Ser Arg Asp Ala Ala Arg His Thr Ala Gly Ala Lys Arg Tyr 
            20                  25                  30          


Lys Tyr Leu Arg Arg Leu Phe Arg Phe Arg Gln Met Asp Phe Glu Phe 
        35                  40                  45              


Ala Ala Trp Gln Met Leu Tyr Leu Phe Thr Ser Pro Gln Arg Val Tyr 
    50                  55                  60                  


Arg Asn Phe His Tyr Arg Lys Gln Thr Lys Asp Gln Trp Ala Arg Asp 
65                  70                  75                  80  


Asp Pro Ala Phe Leu Val Leu Leu Ser Ile Trp Leu Cys Val Ser Thr 
                85                  90                  95      


Ile Gly Phe Gly Phe Val Leu Asp Met Gly Phe Phe Glu Thr Ile Lys 
            100                 105                 110         


Leu Leu Leu Trp Val Val Leu Ile Asp Cys Val Gly Val Gly Leu Leu 
        115                 120                 125             


Ile Ala Thr Leu Met Trp Phe Ile Ser Asn Lys Tyr Leu Val Lys Arg 
    130                 135                 140                 


Gln Ser Arg Asp Tyr Asp Val Glu Trp Gly Tyr Ala Phe Asp Val His 
145                 150                 155                 160 


Leu Asn Ala Phe Tyr Pro Leu Leu Val Ile Leu His Phe Ile Gln Leu 
                165                 170                 175     


Phe Phe Ile Asn His Val Ile Leu Thr Asp Thr Phe Ile Gly Tyr Leu 
            180                 185                 190         


Val Gly Asn Thr Leu Trp Leu Val Ala Val Gly Tyr Tyr Ile Tyr Val 
        195                 200                 205             


Thr Phe Leu Gly Tyr Ser Ala Leu Pro Phe Leu Lys Asn Thr Val Ile 
    210                 215                 220                 


Leu Leu Tyr Pro Phe Ala Pro Leu Ile Leu Leu Tyr Gly Leu Ser Leu 
225                 230                 235                 240 


Ala Leu Gly Trp Asn Phe Thr His Thr Leu Cys Ser Phe Tyr Lys Tyr 
                245                 250                 255     


Arg Val Lys 
            


<210>  3862
<211>  713
<212>  PRT
<213>  Homo sapiens

<400>  3862

Met Leu Leu Ala Thr Leu Leu Leu Leu Leu Leu Gly Gly Ala Leu Ala 
1               5                   10                  15      


His Pro Asp Arg Ile Ile Phe Pro Asn His Ala Cys Glu Asp Pro Pro 
            20                  25                  30          


Ala Val Leu Leu Glu Val Gln Gly Thr Leu Gln Arg Pro Leu Val Arg 
        35                  40                  45              


Asp Ser Arg Thr Ser Pro Ala Asn Cys Thr Trp Leu Ile Leu Gly Ser 
    50                  55                  60                  


Lys Glu Gln Thr Val Thr Ile Arg Phe Gln Lys Leu His Leu Ala Cys 
65                  70                  75                  80  


Gly Ser Glu Arg Leu Thr Leu Arg Ser Pro Leu Gln Pro Leu Ile Ser 
                85                  90                  95      


Leu Cys Glu Ala Pro Pro Ser Pro Leu Gln Leu Pro Gly Gly Asn Val 
            100                 105                 110         


Thr Ile Thr Tyr Ser Tyr Ala Gly Ala Arg Ala Pro Met Gly Gln Gly 
        115                 120                 125             


Phe Leu Leu Ser Tyr Ser Gln Asp Trp Leu Met Cys Leu Gln Glu Glu 
    130                 135                 140                 


Phe Gln Cys Leu Asn His Arg Cys Val Ser Ala Val Gln Arg Cys Asp 
145                 150                 155                 160 


Gly Val Asp Ala Cys Gly Asp Gly Ser Asp Glu Ala Gly Cys Ser Ser 
                165                 170                 175     


Asp Pro Phe Pro Gly Leu Thr Pro Arg Pro Val Pro Ser Leu Pro Cys 
            180                 185                 190         


Asn Val Thr Leu Glu Asp Phe Tyr Gly Val Phe Ser Ser Pro Gly Tyr 
        195                 200                 205             


Thr His Leu Ala Ser Val Ser His Pro Gln Ser Cys His Trp Leu Leu 
    210                 215                 220                 


Asp Pro His Asp Gly Arg Arg Leu Ala Val Arg Phe Thr Ala Leu Asp 
225                 230                 235                 240 


Leu Gly Phe Gly Asp Ala Val His Val Tyr Asp Gly Pro Gly Pro Pro 
                245                 250                 255     


Glu Ser Ser Arg Leu Leu Arg Ser Leu Thr His Phe Ser Asn Gly Lys 
            260                 265                 270         


Ala Val Thr Val Glu Thr Leu Ser Gly Gln Ala Val Val Ser Tyr His 
        275                 280                 285             


Thr Val Ala Trp Ser Asn Gly Arg Gly Phe Asn Ala Thr Tyr His Val 
    290                 295                 300                 


Arg Gly Tyr Cys Leu Pro Trp Asp Arg Pro Cys Gly Leu Gly Ser Gly 
305                 310                 315                 320 


Leu Gly Ala Gly Glu Gly Leu Gly Glu Arg Cys Tyr Ser Glu Ala Gln 
                325                 330                 335     


Arg Cys Asp Gly Ser Trp Asp Cys Ala Asp Gly Thr Asp Glu Glu Asp 
            340                 345                 350         


Cys Pro Gly Cys Pro Pro Gly His Phe Pro Cys Gly Ala Ala Gly Thr 
        355                 360                 365             


Ser Gly Ala Thr Ala Cys Tyr Leu Pro Ala Asp Arg Cys Asn Tyr Gln 
    370                 375                 380                 


Thr Phe Cys Ala Asp Gly Ala Asp Glu Arg Arg Cys Arg His Cys Gln 
385                 390                 395                 400 


Pro Gly Asn Phe Arg Cys Arg Asp Glu Lys Cys Val Tyr Glu Thr Trp 
                405                 410                 415     


Val Cys Asp Gly Gln Pro Asp Cys Ala Asp Gly Ser Asp Glu Trp Asp 
            420                 425                 430         


Cys Ser Tyr Val Leu Pro Arg Lys Val Ile Thr Ala Ala Val Ile Gly 
        435                 440                 445             


Ser Leu Val Cys Gly Leu Leu Leu Val Ile Ala Leu Gly Cys Thr Cys 
    450                 455                 460                 


Lys Leu Tyr Ala Ile Arg Thr Gln Glu Tyr Ser Ile Phe Ala Pro Leu 
465                 470                 475                 480 


Ser Arg Met Glu Ala Glu Ile Val Gln Gln Gln Ala Pro Pro Ser Tyr 
                485                 490                 495     


Gly Gln Leu Ile Ala Gln Gly Ala Ile Pro Pro Val Glu Asp Phe Pro 
            500                 505                 510         


Thr Glu Asn Pro Asn Asp Asn Ser Val Leu Gly Asn Leu Arg Ser Leu 
        515                 520                 525             


Leu Gln Ile Leu Arg Gln Asp Met Thr Pro Gly Gly Gly Pro Gly Ala 
    530                 535                 540                 


Arg Arg Arg Gln Arg Gly Arg Leu Met Arg Arg Leu Val Arg Arg Leu 
545                 550                 555                 560 


Arg Arg Trp Gly Leu Leu Pro Arg Thr Asn Thr Pro Ala Arg Ala Ser 
                565                 570                 575     


Glu Ala Arg Ser Gln Val Thr Pro Ser Ala Ala Pro Leu Glu Ala Leu 
            580                 585                 590         


Asp Gly Gly Thr Gly Pro Ala Arg Glu Gly Gly Ala Val Gly Gly Gln 
        595                 600                 605             


Asp Gly Glu Gln Ala Pro Pro Leu Pro Ile Lys Ala Pro Leu Pro Ser 
    610                 615                 620                 


Ala Ser Thr Ser Pro Ala Pro Thr Thr Val Pro Glu Ala Pro Gly Pro 
625                 630                 635                 640 


Leu Pro Ser Leu Pro Leu Glu Pro Ser Leu Leu Ser Gly Val Val Gln 
                645                 650                 655     


Ala Leu Arg Gly Arg Leu Leu Pro Ser Leu Gly Pro Pro Gly Pro Thr 
            660                 665                 670         


Arg Ser Pro Pro Gly Pro His Thr Ala Val Leu Ala Leu Glu Asp Glu 
        675                 680                 685             


Asp Asp Val Leu Leu Val Pro Leu Ala Glu Pro Gly Val Trp Val Ala 
    690                 695                 700                 


Glu Ala Glu Asp Glu Pro Leu Leu Thr 
705                 710             


<210>  3863
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  3863

Met Asp Leu Ile Gly Phe Gly Tyr Ala Ala Leu Val Thr Phe Gly Ser 
1               5                   10                  15      


Ile Phe Gly Tyr Lys Arg Arg Gly Gly Val Pro Ser Leu Ile Ala Gly 
            20                  25                  30          


Leu Phe Val Gly Cys Leu Ala Gly Tyr Gly Ala Tyr Arg Val Ser Asn 
        35                  40                  45              


Asp Lys Arg Asp Val Lys Val Ser Leu Phe Thr Ala Phe Phe Leu Ala 
    50                  55                  60                  


Thr Ile Met Gly Val Arg Phe Lys Arg Ser Lys Lys Ile Met Pro Ala 
65                  70                  75                  80  


Gly Leu Val Ala Gly Leu Ser Leu Met Met Ile Leu Arg Leu Val Leu 
                85                  90                  95      


Leu Leu Leu 
            


<210>  3864
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  3864

Met Ala Arg Pro Asp Asp Glu Glu Gly Ala Ala Val Ala Pro Gly His 
1               5                   10                  15      


Pro Leu Ala Lys Gly Tyr Leu Pro Leu Pro Arg Gly Ala Pro Val Gly 
            20                  25                  30          


Lys Glu Ser Val Glu Leu Gln Asn Gly Pro Lys Ala Gly Thr Phe Pro 
        35                  40                  45              


Val Asn Gly Ala Pro Arg Asp Ser Leu Ala Ala Ala Ser Gly Val Leu 
    50                  55                  60                  


Gly Gly Pro Gln Thr Pro Leu Ala Pro Glu Glu Glu Thr Gln Ala Arg 
65                  70                  75                  80  


Leu Leu Pro Ala Gly Ala Gly Ala Glu Thr Pro Gly Ala Glu Ser Ser 
                85                  90                  95      


Pro Leu Pro Leu Thr Ala Leu Ser Pro Arg Arg Phe Val Val Leu Leu 
            100                 105                 110         


Ile Phe Ser Leu Tyr Ser Leu Val Asn Ala Phe Gln Trp Ile Gln Tyr 
        115                 120                 125             


Ser Ile Ile Ser Asn Val Phe Glu Gly Phe Tyr Gly Val Thr Leu Leu 
    130                 135                 140                 


His Ile Asp Trp Leu Ser Met Val Tyr Met Leu Ala Tyr Val Pro Leu 
145                 150                 155                 160 


Ile Phe Pro Ala Thr Trp Leu Leu Asp Thr Arg Gly Leu Arg Leu Thr 
                165                 170                 175     


Ala Leu Leu Gly Ser Gly Leu Asn Cys Leu Gly Ala Trp Ile Lys Cys 
            180                 185                 190         


Gly Ser Val Gln Gln His Leu Phe Trp Val Thr Met Leu Gly Gln Cys 
        195                 200                 205             


Leu Cys Ser Val Ala Gln Val Phe Ile Leu Gly Leu Pro Ser Arg Ile 
    210                 215                 220                 


Ala Ser Val Trp Phe Gly Pro Lys Glu Val Ser Thr Ala Cys Ala Thr 
225                 230                 235                 240 


Ala Val Leu Gly Asn Gln Leu Gly Thr Ala Val Gly Phe Leu Leu Pro 
                245                 250                 255     


Pro Val Leu Val Pro Asn Thr Gln Asn Asp Thr Asn Leu Leu Ala Cys 
            260                 265                 270         


Asn Ile Ser Thr Met Phe Tyr Gly Thr Ser Ala Val Ala Thr Leu Leu 
        275                 280                 285             


Phe Ile Leu Thr Ala Ile Ala Phe Lys Glu Lys Pro Arg Tyr Pro Pro 
    290                 295                 300                 


Ser Gln Ala Gln Ala Ala Leu Gln Asp Ser Pro Pro Glu Glu Tyr Ser 
305                 310                 315                 320 


Tyr Lys Lys Ser Ile Arg Asn Leu Phe Lys Asn Ile Pro Phe Val Leu 
                325                 330                 335     


Leu Leu Ile Thr Tyr Gly Ile Met Thr Gly Ala Phe Tyr Ser Val Ser 
            340                 345                 350         


Thr Leu Leu Asn Gln Met Ile Leu Thr Tyr Tyr Glu Gly Glu Glu Val 
        355                 360                 365             


Asn Ala Gly Arg Ile Gly Leu Thr Leu Val Val Ala Gly Met Val Gly 
    370                 375                 380                 


Ser Ile Leu Cys Gly Leu Trp Leu Asp Tyr Thr Lys Thr Tyr Lys Gln 
385                 390                 395                 400 


Thr Thr Leu Ile Val Tyr Ile Leu Ser Phe Ile Gly Met Val Ile Phe 
                405                 410                 415     


Thr Phe Thr Leu Asp Leu Arg Tyr Ile Ile Ile Val Phe Val Thr Gly 
            420                 425                 430         


Gly Val Leu Gly Phe Phe Met Thr Gly Tyr Leu Pro Leu Gly Phe Glu 
        435                 440                 445             


Phe Ala Val Glu Ile Thr Tyr Pro Glu Ser Glu Gly Thr Ser Ser Gly 
    450                 455                 460                 


Leu Leu Asn Ala Ser Ala Gln Ile Phe Gly Ile Leu Phe Thr Leu Ala 
465                 470                 475                 480 


Gln Gly Lys Leu Thr Ser Asp Tyr Gly Pro Lys Ala Gly Asn Ile Phe 
                485                 490                 495     


Leu Cys Val Trp Met Phe Ile Gly Ile Ile Leu Thr Ala Leu Ile Lys 
            500                 505                 510         


Ser Asp Leu Arg Arg His Asn Ile Asn Ile Gly Ile Thr Asn Val Asp 
        515                 520                 525             


Val Lys Ala Ile Pro Ala Asp Ser Pro Thr Asp Gln Glu Pro Lys Thr 
    530                 535                 540                 


Val Met Leu Ser Lys Gln Ser Glu Ser Ala Ile 
545                 550                 555 


<210>  3865
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  3865

Met Ser Thr Asp Thr Gly Val Ser Leu Pro Ser Tyr Glu Glu Asp Gln 
1               5                   10                  15      


Gly Ser Lys Leu Ile Arg Lys Ala Lys Glu Ala Pro Phe Val Pro Val 
            20                  25                  30          


Gly Ile Ala Gly Phe Ala Ala Ile Val Ala Tyr Gly Leu Tyr Lys Leu 
        35                  40                  45              


Lys Ser Arg Gly Asn Thr Lys Met Ser Ile His Leu Ile His Met Arg 
    50                  55                  60                  


Val Ala Ala Gln Gly Phe Val Val Gly Ala Met Thr Val Gly Met Gly 
65                  70                  75                  80  


Tyr Ser Met Tyr Arg Glu Phe Trp Ala Lys Pro Lys Pro 
                85                  90              


<210>  3866
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  3866

Met Met Tyr Arg Pro Asp Val Val Arg Ala Arg Lys Arg Val Cys Trp 
1               5                   10                  15      


Glu Pro Trp Val Ile Gly Leu Val Ile Phe Ile Ser Leu Ile Val Leu 
            20                  25                  30          


Ala Val Cys Ile Gly Leu Thr Val His Tyr Val Arg Tyr Asn Gln Lys 
        35                  40                  45              


Lys Thr Tyr Asn Tyr Tyr Ser Thr Leu Ser Phe Thr Thr Asp Lys Leu 
    50                  55                  60                  


Tyr Ala Glu Phe Gly Arg Glu Ala Ser Asn Asn Phe Thr Glu Met Ser 
65                  70                  75                  80  


Gln Arg Leu Glu Ser Met Val Lys Asn Ala Phe Tyr Lys Ser Pro Leu 
                85                  90                  95      


Arg Glu Glu Phe Val Lys Ser Gln Val Ile Lys Phe Ser Gln Gln Lys 
            100                 105                 110         


His Gly Val Leu Ala His Met Leu Leu Ile Cys Arg Phe His Ser Thr 
        115                 120                 125             


Glu Asp Pro Glu Thr Val Asp Lys Ile Val Gln Leu Val Leu His Glu 
    130                 135                 140                 


Lys Leu Gln Asp Ala Val Gly Pro Pro Lys Val Asp Pro His Ser Val 
145                 150                 155                 160 


Lys Ile Lys Lys Ile Asn Lys Thr Glu Thr Asp Ser Tyr Leu Asn His 
                165                 170                 175     


Cys Cys Gly Thr Arg Arg Ser Lys Thr Leu Gly Gln Ser Leu Arg Ile 
            180                 185                 190         


Val Gly Gly Thr Glu Val Glu Glu Gly Glu Trp Pro Trp Gln Ala Ser 
        195                 200                 205             


Leu Gln Trp Asp Gly Ser His Arg Cys Gly Ala Thr Leu Ile Asn Ala 
    210                 215                 220                 


Thr Trp Leu Val Ser Ala Ala His Cys Phe Thr Thr Tyr Lys Asn Pro 
225                 230                 235                 240 


Ala Arg Trp Thr Ala Ser Phe Gly Val Thr Ile Lys Pro Ser Lys Met 
                245                 250                 255     


Lys Arg Gly Leu Arg Arg Ile Ile Val His Glu Lys Tyr Lys His Pro 
            260                 265                 270         


Ser His Asp Tyr Asp Ile Ser Leu Ala Glu Leu Ser Ser Pro Val Pro 
        275                 280                 285             


Tyr Thr Asn Ala Val His Arg Val Cys Leu Pro Asp Ala Ser Tyr Glu 
    290                 295                 300                 


Phe Gln Pro Gly Asp Val Met Phe Val Thr Gly Phe Gly Ala Leu Lys 
305                 310                 315                 320 


Asn Asp Gly Tyr Ser Gln Asn His Leu Arg Gln Ala Gln Val Thr Leu 
                325                 330                 335     


Ile Asp Ala Thr Thr Cys Asn Glu Pro Gln Ala Tyr Asn Asp Ala Ile 
            340                 345                 350         


Thr Pro Arg Met Leu Cys Ala Gly Ser Leu Glu Gly Lys Thr Asp Ala 
        355                 360                 365             


Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Ser Ser Asp Ala Arg Asp 
    370                 375                 380                 


Ile Trp Tyr Leu Ala Gly Ile Val Ser Trp Gly Asp Glu Cys Ala Lys 
385                 390                 395                 400 


Pro Asn Lys Pro Gly Val Tyr Thr Arg Val Thr Ala Leu Arg Asp Trp 
                405                 410                 415     


Ile Thr Ser Lys Thr Gly Ile 
            420             


<210>  3867
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  3867

Met Pro Arg Gly Arg Lys Ser Arg Arg Arg Arg Asn Ala Arg Ala Ala 
1               5                   10                  15      


Glu Glu Asn Arg Asn Asn Arg Lys Ile Gln Ala Ser Glu Ala Ser Glu 
            20                  25                  30          


Thr Pro Met Ala Ala Ser Val Val Ala Ser Thr Pro Glu Asp Asp Leu 
        35                  40                  45              


Ser Gly Pro Glu Glu Asp Pro Ser Thr Pro Glu Glu Ala Ser Thr Thr 
    50                  55                  60                  


Pro Glu Glu Ala Ser Ser Thr Ala Gln Ala Gln Lys Pro Ser Val Pro 
65                  70                  75                  80  


Arg Ser Asn Phe Gln Gly Thr Lys Lys Ser Leu Leu Met Ser Ile Leu 
                85                  90                  95      


Ala Leu Ile Phe Ile Met Gly Asn Ser Ala Lys Glu Ala Leu Val Trp 
            100                 105                 110         


Lys Val Leu Gly Lys Leu Gly Met Gln Pro Gly Arg Gln His Ser Ile 
        115                 120                 125             


Phe Gly Asp Pro Lys Lys Ile Val Thr Glu Glu Phe Val Arg Arg Gly 
    130                 135                 140                 


Tyr Leu Ile Tyr Lys Pro Val Pro Arg Ser Ser Pro Val Glu Tyr Glu 
145                 150                 155                 160 


Phe Phe Trp Gly Pro Arg Ala His Val Glu Ser Ser Lys Leu Lys Val 
                165                 170                 175     


Met His Phe Val Ala Arg Val Arg Asn Arg Cys Ser Lys Asp Trp Pro 
            180                 185                 190         


Cys Asn Tyr Asp Trp Asp Ser Asp Asp Asp Ala Glu Val Glu Ala Ile 
        195                 200                 205             


Leu Asn Ser Gly Ala Arg Gly Tyr Ser Ala Pro 
    210                 215                 


<210>  3868
<211>  1548
<212>  PRT
<213>  Homo sapiens

<400>  3868

Met Leu Arg Ala Arg Pro Glu Ala Leu Met Leu Leu Gly Ala Leu Leu 
1               5                   10                  15      


Thr Gly Ser Leu Gly Pro Ser Gly Asn Gln Asp Ala Leu Ser Leu Pro 
            20                  25                  30          


Trp Glu Val Gln Arg Tyr Asp Gly Trp Phe Asn Asn Leu Arg His His 
        35                  40                  45              


Glu Arg Gly Ala Val Gly Cys Arg Leu Gln Arg Arg Val Pro Ala Asn 
    50                  55                  60                  


Tyr Ala Asp Gly Val Tyr Gln Ala Leu Glu Glu Pro Gln Leu Pro Asn 
65                  70                  75                  80  


Pro Arg Arg Leu Ser Asn Ala Ala Thr Arg Gly Ile Ala Gly Leu Pro 
                85                  90                  95      


Ser Leu His Asn Arg Thr Val Leu Gly Val Phe Phe Gly Tyr His Val 
            100                 105                 110         


Leu Ser Asp Val Val Ser Val Glu Thr Pro Gly Cys Pro Ala Glu Phe 
        115                 120                 125             


Leu Asn Ile Arg Ile Pro Pro Gly Asp Pro Val Phe Asp Pro Asp Gln 
    130                 135                 140                 


Arg Gly Asp Val Val Leu Pro Phe Gln Arg Ser Arg Trp Asp Pro Glu 
145                 150                 155                 160 


Thr Gly Arg Ser Pro Ser Asn Pro Arg Asp Leu Ala Asn Gln Val Thr 
                165                 170                 175     


Gly Trp Leu Asp Gly Ser Ala Ile Tyr Gly Ser Ser His Ser Trp Ser 
            180                 185                 190         


Asp Ala Leu Arg Ser Phe Ser Gly Gly Gln Leu Ala Ser Gly Pro Asp 
        195                 200                 205             


Pro Ala Phe Pro Arg Asp Ser Gln Asn Pro Leu Leu Met Trp Ala Ala 
    210                 215                 220                 


Pro Asp Pro Ala Thr Gly Gln Asn Gly Pro Arg Gly Leu Tyr Ala Phe 
225                 230                 235                 240 


Gly Ala Glu Arg Gly Asn Arg Glu Pro Phe Leu Gln Ala Leu Gly Leu 
                245                 250                 255     


Leu Trp Phe Arg Tyr His Asn Leu Trp Ala Gln Arg Leu Ala Arg Gln 
            260                 265                 270         


His Pro Asp Trp Glu Asp Glu Glu Leu Phe Gln His Ala Arg Lys Arg 
        275                 280                 285             


Val Ile Ala Thr Tyr Gln Asn Ile Ala Val Tyr Glu Trp Leu Pro Ser 
    290                 295                 300                 


Phe Leu Gln Lys Thr Leu Pro Glu Tyr Thr Gly Tyr Arg Pro Phe Leu 
305                 310                 315                 320 


Asp Pro Ser Ile Ser Pro Glu Phe Val Val Ala Ser Glu Gln Phe Phe 
                325                 330                 335     


Ser Thr Met Val Pro Pro Gly Val Tyr Met Arg Asn Ala Ser Cys His 
            340                 345                 350         


Phe Arg Lys Val Leu Asn Lys Gly Phe Gln Ser Ser Gln Ala Leu Arg 
        355                 360                 365             


Val Cys Asn Asn Tyr Trp Ile Arg Glu Asn Pro Asn Leu Asn Ser Thr 
    370                 375                 380                 


Gln Glu Val Asn Glu Leu Leu Leu Gly Met Ala Ser Gln Ile Ser Glu 
385                 390                 395                 400 


Leu Glu Asp Asn Ile Val Val Glu Asp Leu Arg Asp Tyr Trp Pro Gly 
                405                 410                 415     


Pro Gly Lys Phe Ser Arg Thr Asp Tyr Val Ala Ser Ser Ile Gln Arg 
            420                 425                 430         


Gly Arg Asp Met Gly Leu Pro Ser Tyr Ser Gln Ala Leu Leu Ala Phe 
        435                 440                 445             


Gly Leu Asp Ile Pro Arg Asn Trp Ser Asp Leu Asn Pro Asn Val Asp 
    450                 455                 460                 


Pro Gln Val Leu Glu Ala Thr Ala Ala Leu Tyr Asn Gln Asp Leu Ser 
465                 470                 475                 480 


Gln Leu Glu Leu Leu Leu Gly Gly Leu Leu Glu Ser His Gly Asp Pro 
                485                 490                 495     


Gly Pro Leu Phe Ser Ala Ile Val Leu Asp Gln Phe Val Arg Leu Arg 
            500                 505                 510         


Asp Gly Asp Arg Tyr Trp Phe Glu Asn Thr Arg Asn Gly Leu Phe Ser 
        515                 520                 525             


Lys Lys Glu Ile Glu Asp Ile Arg Asn Thr Thr Leu Arg Asp Val Leu 
    530                 535                 540                 


Val Ala Val Ile Asn Ile Asp Pro Ser Ala Leu Gln Pro Asn Val Phe 
545                 550                 555                 560 


Val Trp His Lys Gly Ala Pro Cys Pro Gln Pro Lys Gln Leu Thr Thr 
                565                 570                 575     


Asp Gly Leu Pro Gln Cys Ala Pro Leu Thr Val Leu Asp Phe Phe Glu 
            580                 585                 590         


Gly Ser Ser Pro Gly Phe Ala Ile Thr Ile Ile Ala Leu Cys Cys Leu 
        595                 600                 605             


Pro Leu Val Ser Leu Leu Leu Ser Gly Val Val Ala Tyr Phe Arg Gly 
    610                 615                 620                 


Arg Glu His Lys Lys Leu Gln Lys Lys Leu Lys Glu Ser Val Lys Lys 
625                 630                 635                 640 


Glu Ala Ala Lys Asp Gly Val Pro Ala Met Glu Trp Pro Gly Pro Lys 
                645                 650                 655     


Glu Arg Ser Ser Pro Ile Ile Ile Gln Leu Leu Ser Asp Arg Cys Leu 
            660                 665                 670         


Gln Val Leu Asn Arg His Leu Thr Val Leu Arg Val Val Gln Leu Gln 
        675                 680                 685             


Pro Leu Gln Gln Val Asn Leu Ile Leu Ser Asn Asn Arg Gly Cys Arg 
    690                 695                 700                 


Thr Leu Leu Leu Lys Ile Pro Lys Glu Tyr Asp Leu Val Leu Leu Phe 
705                 710                 715                 720 


Ser Ser Glu Glu Glu Arg Gly Ala Phe Val Gln Gln Leu Trp Asp Phe 
                725                 730                 735     


Cys Val Arg Trp Ala Leu Gly Leu His Val Ala Glu Met Ser Glu Lys 
            740                 745                 750         


Glu Leu Phe Arg Lys Ala Val Thr Lys Gln Gln Arg Glu Arg Ile Leu 
        755                 760                 765             


Glu Ile Phe Phe Arg His Leu Phe Ala Gln Val Leu Asp Ile Asn Gln 
    770                 775                 780                 


Ala Asp Ala Gly Thr Leu Pro Leu Asp Ser Ser Gln Lys Val Arg Glu 
785                 790                 795                 800 


Ala Leu Thr Cys Glu Leu Ser Arg Ala Glu Phe Ala Glu Ser Leu Gly 
                805                 810                 815     


Leu Lys Pro Gln Asp Met Phe Val Glu Ser Met Phe Ser Leu Ala Asp 
            820                 825                 830         


Lys Asp Gly Asn Gly Tyr Leu Ser Phe Arg Glu Phe Leu Asp Ile Leu 
        835                 840                 845             


Val Val Phe Met Lys Gly Ser Pro Glu Asp Lys Ser Arg Leu Met Phe 
    850                 855                 860                 


Thr Met Tyr Asp Leu Asp Glu Asn Gly Phe Leu Ser Lys Asp Glu Phe 
865                 870                 875                 880 


Phe Thr Met Met Arg Ser Phe Ile Glu Ile Ser Asn Asn Cys Leu Ser 
                885                 890                 895     


Lys Ala Gln Leu Ala Glu Val Val Glu Ser Met Phe Arg Glu Ser Gly 
            900                 905                 910         


Phe Gln Asp Lys Glu Glu Leu Thr Trp Glu Asp Phe His Phe Met Leu 
        915                 920                 925             


Arg Asp His Asp Ser Glu Leu Arg Phe Thr Gln Leu Cys Val Lys Gly 
    930                 935                 940                 


Gly Gly Gly Gly Gly Asn Gly Ile Arg Asp Ile Phe Lys Gln Asn Ile 
945                 950                 955                 960 


Ser Cys Arg Val Ser Phe Ile Thr Arg Thr Pro Gly Glu Arg Ser His 
                965                 970                 975     


Pro Gln Gly Leu Gly Pro Pro Ala Pro Glu Ala Pro Glu Leu Gly Gly 
            980                 985                 990         


Pro Gly Leu Lys Lys Arg Phe Gly  Lys Lys Ala Ala Val  Pro Thr Pro 
        995                 1000                 1005             


Arg Leu  Tyr Thr Glu Ala Leu  Gln Glu Lys Met Gln  Arg Gly Phe 
    1010                 1015                 1020             


Leu Ala  Gln Lys Leu Gln Gln  Tyr Lys Arg Phe Val  Glu Asn Tyr 
    1025                 1030                 1035             


Arg Arg  His Ile Val Cys Val  Ala Ile Phe Ser Ala  Ile Cys Val 
    1040                 1045                 1050             


Gly Val  Phe Ala Asp Arg Ala  Tyr Tyr Tyr Gly Phe  Ala Ser Pro 
    1055                 1060                 1065             


Pro Ser  Asp Ile Ala Gln Thr  Thr Leu Val Gly Ile  Ile Leu Ser 
    1070                 1075                 1080             


Arg Gly  Thr Ala Ala Ser Val  Ser Phe Met Phe Ser  Tyr Ile Leu 
    1085                 1090                 1095             


Leu Thr  Met Cys Arg Asn Leu  Ile Thr Phe Leu Arg  Glu Thr Phe 
    1100                 1105                 1110             


Leu Asn  Arg Tyr Val Pro Phe  Asp Ala Ala Val Asp  Phe His Arg 
    1115                 1120                 1125             


Trp Ile  Ala Met Ala Ala Val  Val Leu Ala Ile Leu  His Ser Ala 
    1130                 1135                 1140             


Gly His  Ala Val Asn Val Tyr  Ile Phe Ser Val Ser  Pro Leu Ser 
    1145                 1150                 1155             


Leu Leu  Ala Cys Ile Phe Pro  Asn Val Phe Val Asn  Asp Gly Ser 
    1160                 1165                 1170             


Lys Leu  Pro Gln Lys Phe Tyr  Trp Trp Phe Phe Gln  Thr Val Pro 
    1175                 1180                 1185             


Gly Met  Thr Gly Val Leu Leu  Leu Leu Val Leu Ala  Ile Met Tyr 
    1190                 1195                 1200             


Val Phe  Ala Ser His His Phe  Arg Arg Arg Ser Phe  Arg Gly Phe 
    1205                 1210                 1215             


Trp Leu  Thr His His Leu Tyr  Ile Leu Leu Tyr Ala  Leu Leu Ile 
    1220                 1225                 1230             


Ile His  Gly Ser Tyr Ala Leu  Ile Gln Leu Pro Thr  Phe His Ile 
    1235                 1240                 1245             


Tyr Phe  Leu Val Pro Ala Ile  Ile Tyr Gly Gly Asp  Lys Leu Val 
    1250                 1255                 1260             


Ser Leu  Ser Arg Lys Lys Val  Glu Ile Ser Val Val  Lys Ala Glu 
    1265                 1270                 1275             


Leu Leu  Pro Ser Gly Val Thr  Tyr Leu Gln Phe Gln  Arg Pro Gln 
    1280                 1285                 1290             


Gly Phe  Glu Tyr Lys Ser Gly  Gln Trp Val Arg Ile  Ala Cys Leu 
    1295                 1300                 1305             


Ala Leu  Gly Thr Thr Glu Tyr  His Pro Phe Thr Leu  Thr Ser Ala 
    1310                 1315                 1320             


Pro His  Glu Asp Thr Leu Ser  Leu His Ile Arg Ala  Val Gly Pro 
    1325                 1330                 1335             


Trp Thr  Thr Arg Leu Arg Glu  Ile Tyr Ser Ser Pro  Lys Gly Asn 
    1340                 1345                 1350             


Gly Cys  Ala Gly Tyr Pro Lys  Leu Tyr Leu Asp Gly  Pro Phe Gly 
    1355                 1360                 1365             


Glu Gly  His Gln Glu Trp His  Lys Phe Glu Val Ser  Val Leu Val 
    1370                 1375                 1380             


Gly Gly  Gly Ile Gly Val Thr  Pro Phe Ala Ser Ile  Leu Lys Asp 
    1385                 1390                 1395             


Leu Val  Phe Lys Ser Ser Leu  Gly Ser Gln Met Leu  Cys Lys Lys 
    1400                 1405                 1410             


Ile Tyr  Phe Ile Trp Val Thr  Arg Thr Gln Arg Gln  Phe Glu Trp 
    1415                 1420                 1425             


Leu Ala  Asp Ile Ile Gln Glu  Val Glu Glu Asn Asp  His Gln Asp 
    1430                 1435                 1440             


Leu Val  Ser Val His Ile Tyr  Val Thr Gln Leu Ala  Glu Lys Phe 
    1445                 1450                 1455             


Asp Leu  Arg Thr Thr Met Leu  Tyr Ile Cys Glu Arg  His Phe Gln 
    1460                 1465                 1470             


Lys Val  Leu Asn Arg Ser Leu  Phe Thr Gly Leu Arg  Ser Ile Thr 
    1475                 1480                 1485             


His Phe  Gly Arg Pro Pro Phe  Glu Pro Phe Phe Asn  Ser Leu Gln 
    1490                 1495                 1500             


Glu Val  His Pro Gln Val Arg  Lys Ile Gly Val Phe  Ser Cys Gly 
    1505                 1510                 1515             


Pro Pro  Gly Met Thr Lys Asn  Val Glu Lys Ala Cys  Gln Leu Val 
    1520                 1525                 1530             


Asn Arg  Gln Asp Arg Ala His  Phe Met His His Tyr  Glu Asn Phe 
    1535                 1540                 1545             


<210>  3869
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  3869

Met Ala Gly Gln Gly Leu Pro Leu His Val Ala Thr Leu Leu Thr Gly 
1               5                   10                  15      


Leu Leu Glu Cys Leu Gly Phe Ala Gly Val Leu Phe Gly Trp Pro Ser 
            20                  25                  30          


Leu Val Phe Val Phe Lys Asn Glu Asp Tyr Phe Lys Asp Leu Cys Gly 
        35                  40                  45              


Pro Asp Ala Gly Pro Ile Gly Asn Ala Thr Gly Gln Ala Asp Cys Lys 
    50                  55                  60                  


Ala Gln Asp Glu Arg Phe Ser Leu Ile Phe Thr Leu Gly Ser Phe Met 
65                  70                  75                  80  


Asn Asn Phe Met Thr Phe Pro Thr Gly Tyr Ile Phe Asp Arg Phe Lys 
                85                  90                  95      


Thr Thr Val Ala Arg Leu Ile Ala Ile Phe Phe Tyr Thr Thr Ala Thr 
            100                 105                 110         


Leu Ile Ile Ala Phe Thr Ser Ala Gly Ser Ala Val Leu Leu Phe Leu 
        115                 120                 125             


Ala Met Pro Met Leu Thr Ile Gly Gly Ile Leu Phe Leu Ile Thr Asn 
    130                 135                 140                 


Leu Gln Ile Gly Asn Leu Phe Gly Gln His Arg Ser Thr Ile Ile Thr 
145                 150                 155                 160 


Leu Tyr Asn Gly Ala Phe Asp Ser Ser Ser Ala Val Phe Leu Ile Ile 
                165                 170                 175     


Lys Leu Leu Tyr Glu Lys Gly Ile Ser Leu Arg Ala Ser Phe Ile Phe 
            180                 185                 190         


Ile Ser Val Cys Ser Thr Trp His Val Ala Arg Thr Phe Leu Leu Met 
        195                 200                 205             


Pro Arg Gly His Ile Pro Tyr Pro Leu Pro Pro Asn Tyr Ser Tyr Gly 
    210                 215                 220                 


Leu Cys Pro Gly Asn Gly Thr Thr Lys Glu Glu Lys Glu Thr Ala Glu 
225                 230                 235                 240 


His Glu Asn Arg Glu Leu Gln Ser Lys Glu Phe Leu Ser Ala Lys Glu 
                245                 250                 255     


Glu Thr Pro Gly Ala Gly Gln Lys Gln Glu Leu Arg Ser Phe Trp Ser 
            260                 265                 270         


Tyr Ala Phe Ser Arg Arg Phe Ala Trp His Leu Val Trp Leu Ser Val 
        275                 280                 285             


Ile Gln Leu Trp His Tyr Leu Phe Ile Gly Thr Leu Asn Ser Leu Leu 
    290                 295                 300                 


Thr Asn Met Ala Gly Gly Asp Met Ala Arg Val Ser Thr Tyr Thr Asn 
305                 310                 315                 320 


Ala Phe Ala Phe Thr Gln Phe Gly Val Leu Cys Ala Pro Trp Asn Gly 
                325                 330                 335     


Leu Leu Met Asp Arg Leu Lys Gln Lys Tyr Gln Lys Glu Ala Arg Lys 
            340                 345                 350         


Thr Gly Ser Ser Thr Leu Ala Val Ala Leu Cys Ser Thr Val Pro Ser 
        355                 360                 365             


Leu Ala Leu Thr Ser Leu Leu Cys Leu Gly Phe Ala Leu Cys Ala Ser 
    370                 375                 380                 


Val Pro Ile Leu Pro Leu Gln Tyr Leu Thr Phe Ile Leu Gln Val Ile 
385                 390                 395                 400 


Ser Arg Ser Phe Leu Tyr Gly Ser Asn Ala Ala Phe Leu Thr Leu Ala 
                405                 410                 415     


Phe Pro Ser Glu His Phe Gly Lys Leu Phe Gly Leu Val Met Ala Leu 
            420                 425                 430         


Ser Ala Val Val Ser Leu Leu Gln Phe Pro Ile Phe Thr Leu Ile Lys 
        435                 440                 445             


Gly Ser Leu Gln Asn Asp Pro Phe Tyr Val Asn Val Met Phe Met Leu 
    450                 455                 460                 


Ala Ile Leu Leu Thr Phe Phe His Pro Phe Leu Val Tyr Arg Glu Cys 
465                 470                 475                 480 


Arg Thr Trp Lys Glu Ser Pro Ser Ala Ile Ala 
                485                 490     


<210>  3870
<211>  1791
<212>  PRT
<213>  Homo sapiens

<400>  3870

Met Asp Asp Arg Cys Tyr Pro Val Ile Phe Pro Asp Glu Arg Asn Phe 
1               5                   10                  15      


Arg Pro Phe Thr Ser Asp Ser Leu Ala Ala Ile Glu Lys Arg Ile Ala 
            20                  25                  30          


Ile Gln Lys Glu Lys Lys Lys Ser Lys Asp Gln Thr Gly Glu Val Pro 
        35                  40                  45              


Gln Pro Arg Pro Gln Leu Asp Leu Lys Ala Ser Arg Lys Leu Pro Lys 
    50                  55                  60                  


Leu Tyr Gly Asp Ile Pro Arg Glu Leu Ile Gly Lys Pro Leu Glu Asp 
65                  70                  75                  80  


Leu Asp Pro Phe Tyr Arg Asn His Lys Thr Phe Met Val Leu Asn Arg 
                85                  90                  95      


Lys Arg Thr Ile Tyr Arg Phe Ser Ala Lys His Ala Leu Phe Ile Phe 
            100                 105                 110         


Gly Pro Phe Asn Ser Ile Arg Ser Leu Ala Ile Arg Val Ser Val His 
        115                 120                 125             


Ser Leu Phe Ser Met Phe Ile Ile Gly Thr Val Ile Ile Asn Cys Val 
    130                 135                 140                 


Phe Met Ala Thr Gly Pro Ala Lys Asn Ser Asn Ser Asn Asn Thr Asp 
145                 150                 155                 160 


Ile Ala Glu Cys Val Phe Thr Gly Ile Tyr Ile Phe Glu Ala Leu Ile 
                165                 170                 175     


Lys Ile Leu Ala Arg Gly Phe Ile Leu Asp Glu Phe Ser Phe Leu Arg 
            180                 185                 190         


Asp Pro Trp Asn Trp Leu Asp Ser Ile Val Ile Gly Ile Ala Ile Val 
        195                 200                 205             


Ser Tyr Ile Pro Gly Ile Thr Ile Lys Leu Leu Pro Leu Arg Thr Phe 
    210                 215                 220                 


Arg Val Phe Arg Ala Leu Lys Ala Ile Ser Val Val Ser Arg Leu Lys 
225                 230                 235                 240 


Val Ile Val Gly Ala Leu Leu Arg Ser Val Lys Lys Leu Val Asn Val 
                245                 250                 255     


Ile Ile Leu Thr Phe Phe Cys Leu Ser Ile Phe Ala Leu Val Gly Gln 
            260                 265                 270         


Gln Leu Phe Met Gly Ser Leu Asn Leu Lys Cys Ile Ser Arg Asp Cys 
        275                 280                 285             


Lys Asn Ile Ser Asn Pro Glu Ala Tyr Asp His Cys Phe Glu Lys Lys 
    290                 295                 300                 


Glu Asn Ser Pro Glu Phe Lys Met Cys Gly Ile Trp Met Gly Asn Ser 
305                 310                 315                 320 


Ala Cys Ser Ile Gln Tyr Glu Cys Lys His Thr Lys Ile Asn Pro Asp 
                325                 330                 335     


Tyr Asn Tyr Thr Asn Phe Asp Asn Phe Gly Trp Ser Phe Leu Ala Met 
            340                 345                 350         


Phe Arg Leu Met Thr Gln Asp Ser Trp Glu Lys Leu Tyr Gln Gln Thr 
        355                 360                 365             


Leu Arg Thr Thr Gly Leu Tyr Ser Val Phe Phe Phe Ile Val Val Ile 
    370                 375                 380                 


Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Thr Leu Ala Val Val Thr 
385                 390                 395                 400 


Met Ala Tyr Glu Glu Gln Asn Lys Asn Val Ala Ala Glu Ile Glu Ala 
                405                 410                 415     


Lys Glu Lys Met Phe Gln Glu Ala Gln Gln Leu Leu Lys Glu Glu Lys 
            420                 425                 430         


Glu Ala Leu Val Ala Met Gly Ile Asp Arg Ser Ser Leu Thr Ser Leu 
        435                 440                 445             


Glu Thr Ser Tyr Phe Thr Pro Lys Lys Arg Lys Leu Phe Gly Asn Lys 
    450                 455                 460                 


Lys Arg Lys Ser Phe Phe Leu Arg Glu Ser Gly Lys Asp Gln Pro Pro 
465                 470                 475                 480 


Gly Ser Asp Ser Asp Glu Asp Cys Gln Lys Lys Pro Gln Leu Leu Glu 
                485                 490                 495     


Gln Thr Lys Arg Leu Ser Gln Asn Leu Ser Leu Asp His Phe Asp Glu 
            500                 505                 510         


His Gly Asp Pro Leu Gln Arg Gln Arg Ala Leu Ser Ala Val Ser Ile 
        515                 520                 525             


Leu Thr Ile Thr Met Lys Glu Gln Glu Lys Ser Gln Glu Pro Cys Leu 
    530                 535                 540                 


Pro Cys Gly Glu Asn Leu Ala Ser Lys Tyr Leu Val Trp Asn Cys Cys 
545                 550                 555                 560 


Pro Gln Trp Leu Cys Val Lys Lys Val Leu Arg Thr Val Met Thr Asp 
                565                 570                 575     


Pro Phe Thr Glu Leu Ala Ile Thr Ile Cys Ile Ile Ile Asn Thr Val 
            580                 585                 590         


Phe Leu Ala Met Glu His His Lys Met Glu Ala Ser Phe Glu Lys Met 
        595                 600                 605             


Leu Asn Ile Gly Asn Leu Val Phe Thr Ser Ile Phe Ile Ala Glu Met 
    610                 615                 620                 


Cys Leu Lys Ile Ile Ala Leu Asp Pro Tyr His Tyr Phe Arg Arg Gly 
625                 630                 635                 640 


Trp Asn Ile Phe Asp Ser Ile Val Ala Leu Leu Ser Phe Ala Asp Val 
                645                 650                 655     


Met Asn Cys Val Leu Gln Lys Arg Ser Trp Pro Phe Leu Arg Ser Phe 
            660                 665                 670         


Arg Val Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn 
        675                 680                 685             


Thr Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Ser Leu 
    690                 695                 700                 


Thr Val Val Leu Val Ile Val Ile Phe Ile Phe Ser Val Val Gly Met 
705                 710                 715                 720 


Gln Leu Phe Gly Arg Ser Phe Asn Ser Gln Lys Ser Pro Lys Leu Cys 
                725                 730                 735     


Asn Pro Thr Gly Pro Thr Val Ser Cys Leu Arg His Trp His Met Gly 
            740                 745                 750         


Asp Phe Trp His Ser Phe Leu Val Val Phe Arg Ile Leu Cys Gly Glu 
        755                 760                 765             


Trp Ile Glu Asn Met Trp Glu Cys Met Gln Glu Ala Asn Ala Ser Ser 
    770                 775                 780                 


Ser Leu Cys Val Ile Val Phe Ile Leu Ile Thr Val Ile Gly Lys Leu 
785                 790                 795                 800 


Val Val Leu Asn Leu Phe Ile Ala Leu Leu Leu Asn Ser Phe Ser Asn 
                805                 810                 815     


Glu Glu Arg Asn Gly Asn Leu Glu Gly Glu Ala Arg Lys Thr Lys Val 
            820                 825                 830         


Gln Leu Ala Leu Asp Arg Phe Arg Arg Ala Phe Cys Phe Val Arg His 
        835                 840                 845             


Thr Leu Glu His Phe Cys His Lys Trp Cys Arg Lys Gln Asn Leu Pro 
    850                 855                 860                 


Gln Gln Lys Glu Val Ala Gly Gly Cys Ala Ala Gln Ser Lys Asp Ile 
865                 870                 875                 880 


Ile Pro Leu Val Met Glu Met Lys Arg Gly Ser Glu Thr Gln Glu Glu 
                885                 890                 895     


Leu Gly Ile Leu Thr Ser Val Pro Lys Thr Leu Gly Val Arg His Asp 
            900                 905                 910         


Trp Thr Trp Leu Ala Pro Leu Ala Glu Glu Glu Asp Asp Val Glu Phe 
        915                 920                 925             


Ser Gly Glu Asp Asn Ala Gln Arg Ile Thr Gln Pro Glu Pro Glu Gln 
    930                 935                 940                 


Gln Ala Tyr Glu Leu His Gln Glu Asn Lys Lys Pro Thr Ser Gln Arg 
945                 950                 955                 960 


Val Gln Ser Val Glu Ile Asp Met Phe Ser Glu Asp Glu Pro His Leu 
                965                 970                 975     


Thr Ile Gln Asp Pro Arg Lys Lys Ser Asp Val Thr Ser Ile Leu Ser 
            980                 985                 990         


Glu Cys Ser Thr Ile Asp Leu Gln  Asp Gly Phe Gly Trp  Leu Pro Glu 
        995                 1000                 1005             


Met Val  Pro Lys Lys Gln Pro  Glu Arg Cys Leu Pro  Lys Gly Phe 
    1010                 1015                 1020             


Gly Cys  Cys Phe Pro Cys Cys  Ser Val Asp Lys Arg  Lys Pro Pro 
    1025                 1030                 1035             


Trp Val  Ile Trp Trp Asn Leu  Arg Lys Thr Cys Tyr  Gln Ile Val 
    1040                 1045                 1050             


Lys His  Ser Trp Phe Glu Ser  Phe Ile Ile Phe Val  Ile Leu Leu 
    1055                 1060                 1065             


Ser Ser  Gly Ala Leu Ile Phe  Glu Asp Val His Leu  Glu Asn Gln 
    1070                 1075                 1080             


Pro Lys  Ile Gln Glu Leu Leu  Asn Cys Thr Asp Ile  Ile Phe Thr 
    1085                 1090                 1095             


His Ile  Phe Ile Leu Glu Met  Val Leu Lys Trp Val  Ala Phe Gly 
    1100                 1105                 1110             


Phe Gly  Lys Tyr Phe Thr Ser  Ala Trp Cys Cys Leu  Asp Phe Ile 
    1115                 1120                 1125             


Ile Val  Ile Val Ser Val Thr  Thr Leu Ile Asn Leu  Met Glu Leu 
    1130                 1135                 1140             


Lys Ser  Phe Arg Thr Leu Arg  Ala Leu Arg Pro Leu  Arg Ala Leu 
    1145                 1150                 1155             


Ser Gln  Phe Glu Gly Met Lys  Val Val Val Asn Ala  Leu Ile Gly 
    1160                 1165                 1170             


Ala Ile  Pro Ala Ile Leu Asn  Val Leu Leu Val Cys  Leu Ile Phe 
    1175                 1180                 1185             


Trp Leu  Val Phe Cys Ile Leu  Gly Val Tyr Phe Phe  Ser Gly Lys 
    1190                 1195                 1200             


Phe Gly  Lys Cys Ile Asn Gly  Thr Asp Ser Val Ile  Asn Tyr Thr 
    1205                 1210                 1215             


Ile Ile  Thr Asn Lys Ser Gln  Cys Glu Ser Gly Asn  Phe Ser Trp 
    1220                 1225                 1230             


Ile Asn  Gln Lys Val Asn Phe  Asp Asn Val Gly Asn  Ala Tyr Leu 
    1235                 1240                 1245             


Ala Leu  Leu Gln Val Ala Thr  Phe Lys Gly Trp Met  Asp Ile Ile 
    1250                 1255                 1260             


Tyr Ala  Ala Val Asp Ser Thr  Glu Lys Glu Gln Gln  Pro Glu Phe 
    1265                 1270                 1275             


Glu Ser  Asn Ser Leu Gly Tyr  Ile Tyr Phe Val Val  Phe Ile Ile 
    1280                 1285                 1290             


Phe Gly  Ser Phe Phe Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile 
    1295                 1300                 1305             


Asp Asn  Phe Asn Gln Gln Gln  Lys Lys Leu Gly Gly  Gln Asp Ile 
    1310                 1315                 1320             


Phe Met  Thr Glu Glu Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys 
    1325                 1330                 1335             


Leu Gly  Ser Lys Lys Pro Gln  Lys Pro Ile Pro Arg  Pro Leu Asn 
    1340                 1345                 1350             


Lys Cys  Gln Gly Leu Val Phe  Asp Ile Val Thr Ser  Gln Ile Phe 
    1355                 1360                 1365             


Asp Ile  Ile Ile Ile Ser Leu  Ile Ile Leu Asn Met  Ile Ser Met 
    1370                 1375                 1380             


Met Ala  Glu Ser Tyr Asn Gln  Pro Lys Ala Met Lys  Ser Ile Leu 
    1385                 1390                 1395             


Asp His  Leu Asn Trp Val Phe  Val Val Ile Phe Thr  Leu Glu Cys 
    1400                 1405                 1410             


Leu Ile  Lys Ile Phe Ala Leu  Arg Gln Tyr Tyr Phe  Thr Asn Gly 
    1415                 1420                 1425             


Trp Asn  Leu Phe Asp Cys Val  Val Val Leu Leu Ser  Ile Val Ser 
    1430                 1435                 1440             


Thr Met  Ile Ser Thr Leu Glu  Asn Gln Glu His Ile  Pro Phe Pro 
    1445                 1450                 1455             


Pro Thr  Leu Phe Arg Ile Val  Arg Leu Ala Arg Ile  Gly Arg Ile 
    1460                 1465                 1470             


Leu Arg  Leu Val Arg Ala Ala  Arg Gly Ile Arg Thr  Leu Leu Phe 
    1475                 1480                 1485             


Ala Leu  Met Met Ser Leu Pro  Ser Leu Phe Asn Ile  Gly Leu Leu 
    1490                 1495                 1500             


Leu Phe  Leu Ile Met Phe Ile  Tyr Ala Ile Leu Gly  Met Asn Trp 
    1505                 1510                 1515             


Phe Ser  Lys Val Asn Pro Glu  Ser Gly Ile Asp Asp  Ile Phe Asn 
    1520                 1525                 1530             


Phe Lys  Thr Phe Ala Ser Ser  Met Leu Cys Leu Phe  Gln Ile Ser 
    1535                 1540                 1545             


Thr Ser  Ala Gly Trp Asp Ser  Leu Leu Ser Pro Met  Leu Arg Ser 
    1550                 1555                 1560             


Lys Glu  Ser Cys Asn Ser Ser  Ser Glu Asn Cys His  Leu Pro Gly 
    1565                 1570                 1575             


Ile Ala  Thr Ser Tyr Phe Val  Ser Tyr Ile Ile Ile  Ser Phe Leu 
    1580                 1585                 1590             


Ile Val  Val Asn Met Tyr Ile  Ala Val Ile Leu Glu  Asn Phe Asn 
    1595                 1600                 1605             


Thr Ala  Thr Glu Glu Ser Glu  Asp Pro Leu Gly Glu  Asp Asp Phe 
    1610                 1615                 1620             


Asp Ile  Phe Tyr Glu Val Trp  Glu Lys Phe Asp Pro  Glu Ala Thr 
    1625                 1630                 1635             


Gln Phe  Ile Lys Tyr Ser Ala  Leu Ser Asp Phe Ala  Asp Ala Leu 
    1640                 1645                 1650             


Pro Glu  Pro Leu Arg Val Ala  Lys Pro Asn Lys Tyr  Gln Phe Leu 
    1655                 1660                 1665             


Val Met  Asp Leu Pro Met Val  Ser Glu Asp Arg Leu  His Cys Met 
    1670                 1675                 1680             


Asp Ile  Leu Phe Ala Phe Thr  Ala Arg Val Leu Gly  Gly Ser Asp 
    1685                 1690                 1695             


Gly Leu  Asp Ser Met Lys Ala  Met Met Glu Glu Lys  Phe Met Glu 
    1700                 1705                 1710             


Ala Asn  Pro Leu Lys Lys Leu  Tyr Glu Pro Ile Val  Thr Thr Thr 
    1715                 1720                 1725             


Lys Arg  Lys Glu Glu Glu Arg  Gly Ala Ala Ile Ile  Gln Lys Ala 
    1730                 1735                 1740             


Phe Arg  Lys Tyr Met Met Lys  Val Thr Lys Gly Asp  Gln Gly Asp 
    1745                 1750                 1755             


Gln Asn  Asp Leu Glu Asn Gly  Pro His Ser Pro Leu  Gln Thr Leu 
    1760                 1765                 1770             


Cys Asn  Gly Asp Leu Ser Ser  Phe Gly Val Ala Lys  Gly Lys Val 
    1775                 1780                 1785             


His Cys  Asp 
    1790     


<210>  3871
<211>  1331
<212>  PRT
<213>  Homo sapiens

<400>  3871

Met Gln Ala Ala Pro Arg Ala Gly Cys Gly Ala Ala Leu Leu Leu Trp 
1               5                   10                  15      


Ile Val Ser Ser Cys Leu Cys Arg Ala Trp Thr Ala Pro Ser Thr Ser 
            20                  25                  30          


Gln Lys Cys Asp Glu Pro Leu Val Ser Gly Leu Pro His Val Ala Phe 
        35                  40                  45              


Ser Ser Ser Ser Ser Ile Ser Gly Ser Tyr Ser Pro Gly Tyr Ala Lys 
    50                  55                  60                  


Ile Asn Lys Arg Gly Gly Ala Gly Gly Trp Ser Pro Ser Asp Ser Asp 
65                  70                  75                  80  


His Tyr Gln Trp Leu Gln Val Asp Phe Gly Asn Arg Lys Gln Ile Ser 
                85                  90                  95      


Ala Ile Ala Thr Gln Gly Arg Tyr Ser Ser Ser Asp Trp Val Thr Gln 
            100                 105                 110         


Tyr Arg Met Leu Tyr Ser Asp Thr Gly Arg Asn Trp Lys Pro Tyr His 
        115                 120                 125             


Gln Asp Gly Asn Ile Trp Ala Phe Pro Gly Asn Ile Asn Ser Asp Gly 
    130                 135                 140                 


Val Val Arg His Glu Leu Gln His Pro Ile Ile Ala Arg Tyr Val Arg 
145                 150                 155                 160 


Ile Val Pro Leu Asp Trp Asn Gly Glu Gly Arg Ile Gly Leu Arg Ile 
                165                 170                 175     


Glu Val Tyr Gly Cys Ser Tyr Trp Ala Asp Val Ile Asn Phe Asp Gly 
            180                 185                 190         


His Val Val Leu Pro Tyr Arg Phe Arg Asn Lys Lys Met Lys Thr Leu 
        195                 200                 205             


Lys Asp Val Ile Ala Leu Asn Phe Lys Thr Ser Glu Ser Glu Gly Val 
    210                 215                 220                 


Ile Leu His Gly Glu Gly Gln Gln Gly Asp Tyr Ile Thr Leu Glu Leu 
225                 230                 235                 240 


Lys Lys Ala Lys Leu Val Leu Ser Leu Asn Leu Gly Ser Asn Gln Leu 
                245                 250                 255     


Gly Pro Ile Tyr Gly His Thr Ser Val Met Thr Gly Ser Leu Leu Asp 
            260                 265                 270         


Asp His His Trp His Ser Val Val Ile Glu Arg Gln Gly Arg Ser Ile 
        275                 280                 285             


Asn Leu Thr Leu Asp Arg Ser Met Gln His Phe Arg Thr Asn Gly Glu 
    290                 295                 300                 


Phe Asp Tyr Leu Asp Leu Asp Tyr Glu Ile Thr Phe Gly Gly Ile Pro 
305                 310                 315                 320 


Phe Ser Gly Lys Pro Ser Ser Ser Ser Arg Lys Asn Phe Lys Gly Cys 
                325                 330                 335     


Met Glu Ser Ile Asn Tyr Asn Gly Val Asn Ile Thr Asp Leu Ala Arg 
            340                 345                 350         


Arg Lys Lys Leu Glu Pro Ser Asn Val Gly Asn Leu Ser Phe Ser Cys 
        355                 360                 365             


Val Glu Pro Tyr Thr Val Pro Val Phe Phe Asn Ala Thr Ser Tyr Leu 
    370                 375                 380                 


Glu Val Pro Gly Arg Leu Asn Gln Asp Leu Phe Ser Val Ser Phe Gln 
385                 390                 395                 400 


Phe Arg Thr Trp Asn Pro Asn Gly Leu Leu Val Phe Ser His Phe Ala 
                405                 410                 415     


Asp Asn Leu Gly Asn Val Glu Ile Asp Leu Thr Glu Ser Lys Val Gly 
            420                 425                 430         


Val His Ile Asn Ile Thr Gln Thr Lys Met Ser Gln Ile Asp Ile Ser 
        435                 440                 445             


Ser Gly Ser Gly Leu Asn Asp Gly Gln Trp His Glu Val Arg Phe Leu 
    450                 455                 460                 


Ala Lys Glu Asn Phe Ala Ile Leu Thr Ile Asp Gly Asp Glu Ala Ser 
465                 470                 475                 480 


Ala Val Arg Thr Asn Ser Pro Leu Gln Val Lys Thr Gly Glu Lys Tyr 
                485                 490                 495     


Phe Phe Gly Gly Phe Leu Asn Gln Met Asn Asn Ser Ser His Ser Val 
            500                 505                 510         


Leu Gln Pro Ser Phe Gln Gly Cys Met Gln Leu Ile Gln Val Asp Asp 
        515                 520                 525             


Gln Leu Val Asn Leu Tyr Glu Val Ala Gln Arg Lys Pro Gly Ser Phe 
    530                 535                 540                 


Ala Asn Val Ser Ile Asp Met Cys Ala Ile Ile Asp Arg Cys Val Pro 
545                 550                 555                 560 


Asn His Cys Glu His Gly Gly Lys Cys Ser Gln Thr Trp Asp Ser Phe 
                565                 570                 575     


Lys Cys Thr Cys Asp Glu Thr Gly Tyr Ser Gly Ala Thr Cys His Asn 
            580                 585                 590         


Ser Ile Tyr Glu Pro Ser Cys Glu Ala Tyr Lys His Leu Gly Gln Thr 
        595                 600                 605             


Ser Asn Tyr Tyr Trp Ile Asp Pro Asp Gly Ser Gly Pro Leu Gly Pro 
    610                 615                 620                 


Leu Lys Val Tyr Cys Asn Met Thr Glu Asp Lys Val Trp Thr Ile Val 
625                 630                 635                 640 


Ser His Asp Leu Gln Met Gln Thr Pro Val Val Gly Tyr Asn Pro Glu 
                645                 650                 655     


Lys Tyr Ser Val Thr Gln Leu Val Tyr Ser Ala Ser Met Asp Gln Ile 
            660                 665                 670         


Ser Ala Ile Thr Asp Ser Ala Glu Tyr Cys Glu Gln Tyr Val Ser Tyr 
        675                 680                 685             


Phe Cys Lys Met Ser Arg Leu Leu Asn Thr Pro Asp Gly Ser Pro Tyr 
    690                 695                 700                 


Thr Trp Trp Val Gly Lys Ala Asn Glu Lys His Tyr Tyr Trp Gly Gly 
705                 710                 715                 720 


Ser Gly Pro Gly Ile Gln Lys Cys Ala Cys Gly Ile Glu Arg Asn Cys 
                725                 730                 735     


Thr Asp Pro Lys Tyr Tyr Cys Asn Cys Asp Ala Asp Tyr Lys Gln Trp 
            740                 745                 750         


Arg Lys Asp Ala Gly Phe Leu Ser Tyr Lys Asp His Leu Pro Val Ser 
        755                 760                 765             


Gln Val Val Val Gly Asp Thr Asp Arg Gln Gly Ser Glu Ala Lys Leu 
    770                 775                 780                 


Ser Val Gly Pro Leu Arg Cys Gln Gly Asp Arg Asn Tyr Trp Asn Ala 
785                 790                 795                 800 


Ala Ser Phe Pro Asn Pro Ser Ser Tyr Leu His Phe Ser Thr Phe Gln 
                805                 810                 815     


Gly Glu Thr Ser Ala Asp Ile Ser Phe Tyr Phe Lys Thr Leu Thr Pro 
            820                 825                 830         


Trp Gly Val Phe Leu Glu Asn Met Gly Lys Glu Asp Phe Ile Lys Leu 
        835                 840                 845             


Glu Leu Lys Ser Ala Thr Glu Val Ser Phe Ser Phe Asp Val Gly Asn 
    850                 855                 860                 


Gly Pro Val Glu Ile Val Val Arg Ser Pro Thr Pro Leu Asn Asp Asp 
865                 870                 875                 880 


Gln Trp His Arg Val Thr Ala Glu Arg Asn Val Lys Gln Ala Ser Leu 
                885                 890                 895     


Gln Val Asp Arg Leu Pro Gln Gln Ile Arg Lys Ala Pro Thr Glu Gly 
            900                 905                 910         


His Thr Arg Leu Glu Leu Tyr Ser Gln Leu Phe Val Gly Gly Ala Gly 
        915                 920                 925             


Gly Gln Gln Gly Phe Leu Gly Cys Ile Arg Ser Leu Arg Met Asn Gly 
    930                 935                 940                 


Val Thr Leu Asp Leu Glu Glu Arg Ala Lys Val Thr Ser Gly Phe Ile 
945                 950                 955                 960 


Ser Gly Cys Ser Gly His Cys Thr Ser Tyr Gly Thr Asn Cys Glu Asn 
                965                 970                 975     


Gly Gly Lys Cys Leu Glu Arg Tyr His Gly Tyr Ser Cys Asp Cys Ser 
            980                 985                 990         


Asn Thr Ala Tyr Asp Gly Thr Phe  Cys Asn Lys Asp Val  Gly Ala Phe 
        995                 1000                 1005             


Phe Glu  Glu Gly Met Trp Leu  Arg Tyr Asn Phe Gln  Ala Pro Ala 
    1010                 1015                 1020             


Thr Asn  Ala Arg Asp Ser Ser  Ser Arg Val Asp Asn  Ala Pro Asp 
    1025                 1030                 1035             


Gln Gln  Asn Ser His Pro Asp  Leu Ala Gln Glu Glu  Ile Arg Phe 
    1040                 1045                 1050             


Ser Phe  Ser Thr Thr Lys Ala  Pro Cys Ile Leu Leu  Tyr Ile Ser 
    1055                 1060                 1065             


Ser Phe  Thr Thr Asp Phe Leu  Ala Val Leu Val Lys  Pro Thr Gly 
    1070                 1075                 1080             


Ser Leu  Gln Ile Arg Tyr Asn  Leu Gly Gly Thr Arg  Glu Pro Tyr 
    1085                 1090                 1095             


Asn Ile  Asp Val Asp His Arg  Asn Met Ala Asn Gly  Gln Pro His 
    1100                 1105                 1110             


Ser Val  Asn Ile Thr Arg His  Glu Lys Thr Ile Phe  Leu Lys Leu 
    1115                 1120                 1125             


Asp His  Tyr Pro Ser Val Ser  Tyr His Leu Pro Ser  Ser Ser Asp 
    1130                 1135                 1140             


Thr Leu  Phe Asn Ser Pro Lys  Ser Leu Phe Leu Gly  Lys Val Ile 
    1145                 1150                 1155             


Glu Thr  Gly Lys Ile Asp Gln  Glu Ile His Lys Tyr  Asn Thr Pro 
    1160                 1165                 1170             


Gly Phe  Thr Gly Cys Leu Ser  Arg Val Gln Phe Asn  Gln Ile Ala 
    1175                 1180                 1185             


Pro Leu  Lys Ala Ala Leu Arg  Gln Thr Asn Ala Ser  Ala His Val 
    1190                 1195                 1200             


His Ile  Gln Gly Glu Leu Val  Glu Ser Asn Cys Gly  Ala Ser Pro 
    1205                 1210                 1215             


Leu Thr  Leu Ser Pro Met Ser  Ser Ala Thr Asp Pro  Trp His Leu 
    1220                 1225                 1230             


Asp His  Leu Asp Ser Ala Ser  Ala Asp Phe Pro Tyr  Asn Pro Gly 
    1235                 1240                 1245             


Gln Gly  Gln Ala Ile Arg Asn  Gly Val Asn Arg Asn  Ser Ala Ile 
    1250                 1255                 1260             


Ile Gly  Gly Val Ile Ala Val  Val Ile Phe Thr Ile  Leu Cys Thr 
    1265                 1270                 1275             


Leu Val  Phe Leu Ile Arg Tyr  Met Phe Arg His Lys  Gly Thr Tyr 
    1280                 1285                 1290             


His Thr  Asn Glu Ala Lys Gly  Ala Glu Ser Ala Glu  Ser Ala Asp 
    1295                 1300                 1305             


Ala Ala  Ile Met Asn Asn Asp  Pro Asn Phe Thr Glu  Thr Ile Asp 
    1310                 1315                 1320             


Glu Ser  Lys Lys Glu Trp Leu  Ile 
    1325                 1330     


<210>  3872
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  3872

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  3873
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  3873

Met Met Pro Ser Arg Thr Asn Leu Ala Thr Gly Ile Pro Ser Ser Lys 
1               5                   10                  15      


Val Lys Tyr Ser Arg Leu Ser Ser Thr Asp Asp Gly Tyr Ile Asp Leu 
            20                  25                  30          


Gln Phe Lys Lys Thr Pro Pro Lys Ile Pro Tyr Lys Ala Ile Ala Leu 
        35                  40                  45              


Ala Thr Val Leu Phe Leu Ile Gly Ala Phe Leu Ile Ile Ile Gly Ser 
    50                  55                  60                  


Leu Leu Leu Ser Gly Tyr Ile Ser Lys Gly Gly Ala Asp Arg Ala Val 
65                  70                  75                  80  


Pro Val Leu Ile Ile Gly Ile Leu Val Phe Leu Pro Gly Phe Tyr His 
                85                  90                  95      


Leu Arg Ile Ala Tyr Tyr Ala Ser Lys Gly Tyr Arg Gly Tyr Ser Tyr 
            100                 105                 110         


Asp Asp Ile Pro Asp Phe Asp Asp 
        115                 120 


<210>  3874
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  3874

Met Ser Pro Ser Gly Arg Leu Cys Leu Leu Thr Ile Val Gly Leu Ile 
1               5                   10                  15      


Leu Pro Thr Arg Gly Gln Thr Leu Lys Asp Thr Thr Ser Ser Ser Ser 
            20                  25                  30          


Ala Asp Ser Thr Ile Met Asp Ile Gln Val Pro Thr Arg Ala Pro Asp 
        35                  40                  45              


Ala Val Tyr Thr Glu Leu Gln Pro Thr Ser Pro Thr Pro Thr Trp Pro 
    50                  55                  60                  


Ala Asp Glu Thr Pro Gln Pro Gln Thr Gln Thr Gln Gln Leu Glu Gly 
65                  70                  75                  80  


Thr Asp Gly Pro Leu Val Thr Asp Pro Glu Thr His Lys Ser Thr Lys 
                85                  90                  95      


Ala Ala His Pro Thr Asp Asp Thr Thr Thr Leu Ser Glu Arg Pro Ser 
            100                 105                 110         


Pro Ser Thr Asp Val Gln Thr Asp Pro Gln Thr Leu Lys Pro Ser Gly 
        115                 120                 125             


Phe His Glu Asp Asp Pro Phe Phe Tyr Asp Glu His Thr Leu Arg Lys 
    130                 135                 140                 


Arg Gly Leu Leu Val Ala Ala Val Leu Phe Ile Thr Gly Ile Ile Ile 
145                 150                 155                 160 


Leu Thr Ser Gly Lys Cys Arg Gln Leu Ser Arg Leu Cys Arg Asn Arg 
                165                 170                 175     


Cys Arg 
        


<210>  3875
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  3875

Met Ile Cys Thr Phe Leu Arg Ala Val Gln Tyr Thr Glu Lys Leu His 
1               5                   10                  15      


Arg Ser Ser Ala Lys Arg Leu Leu Leu Pro Tyr Ile Val Leu Asn Lys 
            20                  25                  30          


Ala Cys Leu Lys Thr Glu Pro Ser Leu Arg Cys Gly Leu Gln Tyr Gln 
        35                  40                  45              


Lys Lys Thr Leu Arg Pro Arg Cys Ile Leu Gly Val Thr Gln Lys Thr 
    50                  55                  60                  


Ile Trp Thr Gln Gly Pro Ser Pro Arg Lys Ala Lys Glu Asp Gly Ser 
65                  70                  75                  80  


Lys Gln Val Ser Val His Arg Ser Gln Arg Gly Gly Thr Ala Val Pro 
                85                  90                  95      


Thr Ser Gln Lys Val Lys Glu Ala Gly Arg Asp Phe Thr Tyr Leu Ile 
            100                 105                 110         


Val Val Leu Phe Gly Ile Ser Ile Thr Gly Gly Leu Phe Tyr Thr Ile 
        115                 120                 125             


Phe Lys Glu Leu Phe Ser Ser Ser Ser Pro Ser Lys Ile Tyr Gly Arg 
    130                 135                 140                 


Ala Leu Glu Lys Cys Arg Ser His Pro Glu Val Ile Gly Val Phe Gly 
145                 150                 155                 160 


Glu Ser Val Lys Gly Tyr Gly Glu Val Thr Arg Arg Gly Arg Arg Gln 
                165                 170                 175     


His Val Arg Phe Thr Glu Tyr Val Lys Asp Gly Leu Lys His Thr Cys 
            180                 185                 190         


Val Lys Phe Tyr Ile Glu Gly Ser Glu Pro Gly Lys Gln Gly Thr Val 
        195                 200                 205             


Tyr Ala Gln Val Lys Glu Asn Pro Gly Ser Gly Glu Tyr Asp Phe Arg 
    210                 215                 220                 


Tyr Ile Phe Val Glu Ile Glu Ser Tyr Pro Arg Arg Thr Ile Ile Ile 
225                 230                 235                 240 


Glu Asp Asn Arg Ser Gln Asp Asp 
                245             


<210>  3876
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  3876

Met Asn Val Gly Val Ala His Ser Glu Val Asn Pro Asn Thr Arg Val 
1               5                   10                  15      


Met Asn Ser Arg Gly Ile Trp Leu Ala Tyr Ile Ile Leu Val Gly Leu 
            20                  25                  30          


Leu His Met Val Leu Leu Ser Ile Pro Phe Phe Ser Ile Pro Val Val 
        35                  40                  45              


Trp Thr Leu Thr Asn Val Ile His Asn Leu Ala Thr Tyr Val Phe Leu 
    50                  55                  60                  


His Thr Val Lys Gly Thr Pro Phe Glu Thr Pro Asp Gln Gly Lys Ala 
65                  70                  75                  80  


Arg Leu Leu Thr His Trp Glu Gln Met Asp Tyr Gly Leu Gln Phe Thr 
                85                  90                  95      


Ser Ser Arg Lys Phe Leu Ser Ile Ser Pro Ile Val Leu Tyr Leu Leu 
            100                 105                 110         


Ala Ser Phe Tyr Thr Lys Tyr Asp Ala Ala His Phe Leu Ile Asn Thr 
        115                 120                 125             


Ala Ser Leu Leu Ser Val Leu Leu Pro Lys Leu Pro Gln Phe His Gly 
    130                 135                 140                 


Val Arg Val Phe Gly Ile Asn Lys Tyr 
145                 150             


<210>  3877
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  3877

Met Glu Ala Val Val Phe Val Phe Ser Leu Leu Asp Cys Cys Ala Leu 
1               5                   10                  15      


Ile Phe Leu Ser Val Tyr Phe Ile Ile Thr Leu Ser Asp Leu Glu Cys 
            20                  25                  30          


Asp Tyr Ile Asn Ala Arg Ser Cys Cys Ser Lys Leu Asn Lys Trp Val 
        35                  40                  45              


Ile Pro Glu Leu Ile Gly His Thr Ile Val Thr Val Leu Leu Leu Met 
    50                  55                  60                  


Ser Leu His Trp Phe Ile Phe Leu Leu Asn Leu Pro Val Ala Thr Trp 
65                  70                  75                  80  


Asn Ile Tyr Arg Tyr Ile Met Val Pro Ser Gly Asn Met Gly Val Phe 
                85                  90                  95      


Asp Pro Thr Glu Ile His Asn Arg Gly Gln Leu Lys Ser His Met Lys 
            100                 105                 110         


Glu Ala Met Ile Lys Leu Gly Phe His Leu Leu Cys Phe Phe Met Tyr 
        115                 120                 125             


Leu Tyr Ser Met Ile Leu Ala Leu Ile Asn Asp 
    130                 135                 


<210>  3878
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  3878

Met Ala Pro Lys Gly Lys Val Gly Thr Arg Gly Lys Lys Gln Ile Phe 
1               5                   10                  15      


Glu Glu Asn Arg Glu Thr Leu Lys Phe Tyr Leu Arg Ile Ile Leu Gly 
            20                  25                  30          


Ala Asn Ala Ile Tyr Cys Leu Val Thr Leu Val Phe Phe Tyr Ser Ser 
        35                  40                  45              


Ala Ser Phe Trp Ala Trp Leu Ala Leu Gly Phe Ser Leu Ala Val Tyr 
    50                  55                  60                  


Gly Ala Ser Tyr His Ser Met Ser Ser Met Ala Arg Ala Ala Phe Ser 
65                  70                  75                  80  


Glu Asp Gly Ala Leu Met Asp Gly Gly Met Asp Leu Asn Met Glu Gln 
                85                  90                  95      


Gly Met Ala Glu His Leu Lys Asp Val Ile Leu Leu Thr Ala Ile Val 
            100                 105                 110         


Gln Val Leu Ser Cys Phe Ser Leu Tyr Val Trp Ser Phe Trp Leu Leu 
        115                 120                 125             


Ala Pro Gly Arg Ala Leu Tyr Leu Leu Trp Val Asn Val Leu Gly Pro 
    130                 135                 140                 


Trp Phe Thr Ala Asp Ser Gly Thr Pro Ala Pro Glu His Asn Glu Lys 
145                 150                 155                 160 


Arg Gln Arg Arg Gln Glu Arg Arg Gln Met Lys Arg Leu 
                165                 170             


<210>  3879
<211>  1980
<212>  PRT
<213>  Homo sapiens

<400>  3879

Met Ala Ala Arg Leu Leu Ala Pro Pro Gly Pro Asp Ser Phe Lys Pro 
1               5                   10                  15      


Phe Thr Pro Glu Ser Leu Ala Asn Ile Glu Arg Arg Ile Ala Glu Ser 
            20                  25                  30          


Lys Leu Lys Lys Pro Pro Lys Ala Asp Gly Ser His Arg Glu Asp Asp 
        35                  40                  45              


Glu Asp Ser Lys Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Ser 
    50                  55                  60                  


Leu Pro Phe Ile Tyr Gly Asp Ile Pro Gln Gly Leu Val Ala Val Pro 
65                  70                  75                  80  


Leu Glu Asp Phe Asp Pro Tyr Tyr Leu Thr Gln Lys Thr Phe Val Val 
                85                  90                  95      


Leu Asn Arg Gly Lys Thr Leu Phe Arg Phe Ser Ala Thr Pro Ala Leu 
            100                 105                 110         


Tyr Ile Leu Ser Pro Phe Asn Leu Ile Arg Arg Ile Ala Ile Lys Ile 
        115                 120                 125             


Leu Ile His Ser Val Phe Ser Met Ile Ile Met Cys Thr Ile Leu Thr 
    130                 135                 140                 


Asn Cys Val Phe Met Thr Phe Ser Asn Pro Pro Asp Trp Ser Lys Asn 
145                 150                 155                 160 


Val Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys 
                165                 170                 175     


Ile Ile Ala Arg Gly Phe Cys Ile Asp Gly Phe Thr Phe Leu Arg Asp 
            180                 185                 190         


Pro Trp Asn Trp Leu Asp Phe Ser Val Ile Met Met Ala Tyr Ile Thr 
        195                 200                 205             


Glu Phe Val Asn Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val 
    210                 215                 220                 


Leu Arg Ala Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile 
225                 230                 235                 240 


Val Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile 
                245                 250                 255     


Leu Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu 
            260                 265                 270         


Phe Met Gly Asn Leu Arg Asn Lys Cys Val Val Trp Pro Ile Asn Phe 
        275                 280                 285             


Asn Glu Ser Tyr Leu Glu Asn Gly Thr Lys Gly Phe Asp Trp Glu Glu 
    290                 295                 300                 


Tyr Ile Asn Asn Lys Thr Asn Phe Tyr Thr Val Pro Gly Met Leu Glu 
305                 310                 315                 320 


Pro Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly 
                325                 330                 335     


Tyr Gln Cys Met Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser 
            340                 345                 350         


Phe Asp Thr Phe Ser Trp Ala Phe Leu Ala Leu Phe Arg Leu Met Thr 
        355                 360                 365             


Gln Asp Tyr Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly 
    370                 375                 380                 


Lys Thr Tyr Met Ile Phe Phe Val Leu Val Ile Phe Val Gly Ser Phe 
385                 390                 395                 400 


Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu 
                405                 410                 415     


Gln Asn Gln Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe 
            420                 425                 430         


Lys Ala Met Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala 
        435                 440                 445             


Ala Ala Met Ala Thr Ser Ala Gly Thr Val Ser Glu Asp Ala Ile Glu 
    450                 455                 460                 


Glu Glu Gly Glu Glu Gly Gly Gly Ser Pro Arg Ser Ser Ser Glu Ile 
465                 470                 475                 480 


Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg Lys 
                485                 490                 495     


Lys Arg Lys Gln Lys Glu Leu Ser Glu Gly Glu Glu Lys Gly Asp Pro 
            500                 505                 510         


Glu Lys Val Phe Lys Ser Glu Ser Glu Asp Gly Met Arg Arg Lys Ala 
        515                 520                 525             


Phe Arg Leu Pro Asp Asn Arg Ile Gly Arg Lys Phe Ser Ile Met Asn 
    530                 535                 540                 


Gln Ser Leu Leu Ser Ile Pro Gly Ser Pro Phe Leu Ser Arg His Asn 
545                 550                 555                 560 


Ser Lys Ser Ser Ile Phe Ser Phe Arg Gly Pro Gly Arg Phe Arg Asp 
                565                 570                 575     


Pro Gly Ser Glu Asn Glu Phe Ala Asp Asp Glu His Ser Thr Val Glu 
            580                 585                 590         


Glu Ser Glu Gly Arg Arg Asp Ser Leu Phe Ile Pro Ile Arg Ala Arg 
        595                 600                 605             


Glu Arg Arg Ser Ser Tyr Ser Gly Tyr Ser Gly Tyr Ser Gln Gly Ser 
    610                 615                 620                 


Arg Ser Ser Arg Ile Phe Pro Ser Leu Arg Arg Ser Val Lys Arg Asn 
625                 630                 635                 640 


Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Ile Gly Gly Pro Gly 
                645                 650                 655     


Ser His Ile Gly Gly Arg Leu Leu Pro Glu Ala Thr Thr Glu Val Glu 
            660                 665                 670         


Ile Lys Lys Lys Gly Pro Gly Ser Leu Leu Val Ser Met Asp Gln Leu 
        675                 680                 685             


Ala Ser Tyr Gly Arg Lys Asp Arg Ile Asn Ser Ile Met Ser Val Val 
    690                 695                 700                 


Thr Asn Thr Leu Val Glu Glu Leu Glu Glu Ser Gln Arg Lys Cys Pro 
705                 710                 715                 720 


Pro Cys Trp Tyr Lys Phe Ala Asn Thr Phe Leu Ile Trp Glu Cys His 
                725                 730                 735     


Pro Tyr Trp Ile Lys Leu Lys Glu Ile Val Asn Leu Ile Val Met Asp 
            740                 745                 750         


Pro Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu 
        755                 760                 765             


Phe Met Ala Met Glu His His Pro Met Thr Pro Gln Phe Glu His Val 
    770                 775                 780                 


Leu Ala Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met 
785                 790                 795                 800 


Phe Leu Lys Leu Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly 
                805                 810                 815     


Trp Asn Ile Phe Asp Gly Phe Ile Val Ser Leu Ser Leu Met Glu Leu 
            820                 825                 830         


Ser Leu Ala Asp Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu 
        835                 840                 845             


Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu 
    850                 855                 860                 


Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu 
865                 870                 875                 880 


Val Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu 
                885                 890                 895     


Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys Lys Ile Asn Gln Asp Cys 
            900                 905                 910         


Glu Leu Pro Arg Trp His Met His Asp Phe Phe His Ser Phe Leu Ile 
        915                 920                 925             


Val Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys 
    930                 935                 940                 


Met Glu Val Ala Gly Gln Ala Met Cys Leu Ile Val Phe Met Met Val 
945                 950                 955                 960 


Met Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu 
                965                 970                 975     


Leu Ser Ser Phe Ser Ala Asp Asn Leu Ala Ala Thr Asp Asp Asp Gly 
            980                 985                 990         


Glu Met Asn Asn Leu Gln Ile Ser  Val Ile Arg Ile Lys  Lys Gly Val 
        995                 1000                 1005             


Ala Trp  Thr Lys Leu Lys Val  His Ala Phe Met Gln  Ala His Phe 
    1010                 1015                 1020             


Lys Gln  Arg Glu Ala Asp Glu  Val Lys Pro Leu Asp  Glu Leu Tyr 
    1025                 1030                 1035             


Glu Lys  Lys Ala Asn Cys Ile  Ala Asn His Thr Gly  Ala Asp Ile 
    1040                 1045                 1050             


His Arg  Asn Gly Asp Phe Gln  Lys Asn Gly Asn Gly  Thr Thr Ser 
    1055                 1060                 1065             


Gly Ile  Gly Ser Ser Val Glu  Lys Tyr Ile Ile Asp  Glu Asp His 
    1070                 1075                 1080             


Met Ser  Phe Ile Asn Asn Pro  Asn Leu Thr Val Arg  Val Pro Ile 
    1085                 1090                 1095             


Ala Val  Gly Glu Ser Asp Phe  Glu Asn Leu Asn Thr  Glu Asp Val 
    1100                 1105                 1110             


Ser Ser  Glu Ser Asp Pro Glu  Gly Ser Lys Asp Lys  Leu Asp Asp 
    1115                 1120                 1125             


Thr Ser  Ser Ser Glu Gly Ser  Thr Ile Asp Ile Lys  Pro Glu Val 
    1130                 1135                 1140             


Glu Glu  Val Pro Val Glu Gln  Pro Glu Glu Tyr Leu  Asp Pro Asp 
    1145                 1150                 1155             


Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg Phe Lys  Cys Cys Gln 
    1160                 1165                 1170             


Val Asn  Ile Glu Glu Gly Leu  Gly Lys Ser Trp Trp  Ile Leu Arg 
    1175                 1180                 1185             


Lys Thr  Cys Phe Leu Ile Val  Glu His Asn Trp Phe  Glu Thr Phe 
    1190                 1195                 1200             


Ile Ile  Phe Met Ile Leu Leu  Ser Ser Gly Ala Leu  Ala Phe Glu 
    1205                 1210                 1215             


Asp Ile  Tyr Ile Glu Gln Arg  Lys Thr Ile Arg Thr  Ile Leu Glu 
    1220                 1225                 1230             


Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe Ile Leu  Glu Met Leu 
    1235                 1240                 1245             


Leu Lys  Trp Thr Ala Tyr Gly  Phe Val Lys Phe Phe  Thr Asn Ala 
    1250                 1255                 1260             


Trp Cys  Trp Leu Asp Phe Leu  Ile Val Ala Val Ser  Leu Val Ser 
    1265                 1270                 1275             


Leu Ile  Ala Asn Ala Leu Gly  Tyr Ser Glu Leu Gly  Ala Ile Lys 
    1280                 1285                 1290             


Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro Leu Arg  Ala Leu Ser 
    1295                 1300                 1305             


Arg Phe  Glu Gly Met Arg Val  Val Val Asn Ala Leu  Val Gly Ala 
    1310                 1315                 1320             


Ile Pro  Ser Ile Met Asn Val  Leu Leu Val Cys Leu  Ile Phe Trp 
    1325                 1330                 1335             


Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu Phe Ala  Gly Lys Tyr 
    1340                 1345                 1350             


His Tyr  Cys Phe Asn Glu Thr  Ser Glu Ile Arg Phe  Glu Ile Glu 
    1355                 1360                 1365             


Asp Val  Asn Asn Lys Thr Glu  Cys Glu Lys Leu Met  Glu Gly Asn 
    1370                 1375                 1380             


Asn Thr  Glu Ile Arg Trp Lys  Asn Val Lys Ile Asn  Phe Asp Asn 
    1385                 1390                 1395             


Val Gly  Ala Gly Tyr Leu Ala  Leu Leu Gln Val Ala  Thr Phe Lys 
    1400                 1405                 1410             


Gly Trp  Met Asp Ile Met Tyr  Ala Ala Val Asp Ser  Arg Lys Pro 
    1415                 1420                 1425             


Asp Glu  Gln Pro Lys Tyr Glu  Asp Asn Ile Tyr Met  Tyr Ile Tyr 
    1430                 1435                 1440             


Phe Val  Ile Phe Ile Ile Phe  Gly Ser Phe Phe Thr  Leu Asn Leu 
    1445                 1450                 1455             


Phe Ile  Gly Val Ile Ile Asp  Asn Phe Asn Gln Gln  Lys Lys Lys 
    1460                 1465                 1470             


Phe Gly  Gly Gln Asp Ile Phe  Met Thr Glu Glu Gln  Lys Lys Tyr 
    1475                 1480                 1485             


Tyr Asn  Ala Met Lys Lys Leu  Gly Ser Lys Lys Pro  Gln Lys Pro 
    1490                 1495                 1500             


Ile Pro  Arg Pro Leu Asn Lys  Ile Gln Gly Ile Val  Phe Asp Phe 
    1505                 1510                 1515             


Val Thr  Gln Gln Ala Phe Asp  Ile Val Ile Met Met  Leu Ile Cys 
    1520                 1525                 1530             


Leu Asn  Met Val Thr Met Met  Val Glu Thr Asp Thr  Gln Ser Lys 
    1535                 1540                 1545             


Gln Met  Glu Asn Ile Leu Tyr  Trp Ile Asn Leu Val  Phe Val Ile 
    1550                 1555                 1560             


Phe Phe  Thr Cys Glu Cys Val  Leu Lys Met Phe Ala  Leu Arg His 
    1565                 1570                 1575             


Tyr Tyr  Phe Thr Ile Gly Trp  Asn Ile Phe Asp Phe  Val Val Val 
    1580                 1585                 1590             


Ile Leu  Ser Ile Val Gly Met  Phe Leu Ala Asp Ile  Ile Glu Lys 
    1595                 1600                 1605             


Tyr Phe  Val Ser Pro Thr Leu  Phe Arg Val Ile Arg  Leu Ala Arg 
    1610                 1615                 1620             


Ile Gly  Arg Ile Leu Arg Leu  Ile Lys Gly Ala Lys  Gly Ile Arg 
    1625                 1630                 1635             


Thr Leu  Leu Phe Ala Leu Met  Met Ser Leu Pro Ala  Leu Phe Asn 
    1640                 1645                 1650             


Ile Gly  Leu Leu Leu Phe Leu  Val Met Phe Ile Phe  Ser Ile Phe 
    1655                 1660                 1665             


Gly Met  Ser Asn Phe Ala Tyr  Val Lys His Glu Ala  Gly Ile Asp 
    1670                 1675                 1680             


Asp Met  Phe Asn Phe Glu Thr  Phe Gly Asn Ser Met  Ile Cys Leu 
    1685                 1690                 1695             


Phe Gln  Ile Thr Thr Ser Ala  Gly Trp Asp Gly Leu  Leu Leu Pro 
    1700                 1705                 1710             


Ile Leu  Asn Arg Pro Pro Asp  Cys Ser Leu Asp Lys  Glu His Pro 
    1715                 1720                 1725             


Gly Ser  Gly Phe Lys Gly Asp  Cys Gly Asn Pro Ser  Val Gly Ile 
    1730                 1735                 1740             


Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser Phe Leu  Ile Val Val 
    1745                 1750                 1755             


Asn Met  Tyr Ile Ala Ile Ile  Leu Glu Asn Phe Ser  Val Ala Thr 
    1760                 1765                 1770             


Glu Glu  Ser Ala Asp Pro Leu  Ser Glu Asp Asp Phe  Glu Thr Phe 
    1775                 1780                 1785             


Tyr Glu  Ile Trp Glu Lys Phe  Asp Pro Asp Ala Thr  Gln Phe Ile 
    1790                 1795                 1800             


Glu Tyr  Cys Lys Leu Ala Asp  Phe Ala Asp Ala Leu  Glu His Pro 
    1805                 1810                 1815             


Leu Arg  Val Pro Lys Pro Asn  Thr Ile Glu Leu Ile  Ala Met Asp 
    1820                 1825                 1830             


Leu Pro  Met Val Ser Gly Asp  Arg Ile His Cys Leu  Asp Ile Leu 
    1835                 1840                 1845             


Phe Ala  Phe Thr Lys Arg Val  Leu Gly Asp Ser Gly  Glu Leu Asp 
    1850                 1855                 1860             


Ile Leu  Arg Gln Gln Met Glu  Glu Arg Phe Val Ala  Ser Asn Pro 
    1865                 1870                 1875             


Ser Lys  Val Ser Tyr Glu Pro  Ile Thr Thr Thr Leu  Arg Arg Lys 
    1880                 1885                 1890             


Gln Glu  Glu Val Ser Ala Val  Val Leu Gln Arg Ala  Tyr Arg Gly 
    1895                 1900                 1905             


His Leu  Ala Arg Arg Gly Phe  Ile Cys Lys Lys Thr  Thr Ser Asn 
    1910                 1915                 1920             


Lys Leu  Glu Asn Gly Gly Thr  His Arg Glu Lys Lys  Glu Ser Thr 
    1925                 1930                 1935             


Pro Ser  Thr Ala Ser Leu Pro  Ser Tyr Asp Ser Val  Thr Lys Pro 
    1940                 1945                 1950             


Glu Lys  Glu Lys Gln Gln Arg  Ala Glu Glu Gly Arg  Arg Glu Arg 
    1955                 1960                 1965             


Ala Lys  Arg Gln Lys Glu Val  Arg Glu Ser Lys Cys  
    1970                 1975                 1980 


<210>  3880
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  3880

Met Glu Leu Glu Ala Met Ser Arg Tyr Thr Ser Pro Val Asn Pro Ala 
1               5                   10                  15      


Val Phe Pro His Leu Thr Val Val Leu Leu Ala Ile Gly Met Phe Phe 
            20                  25                  30          


Thr Ala Trp Phe Phe Val Tyr Glu Val Thr Ser Thr Lys Tyr Thr Arg 
        35                  40                  45              


Asp Ile Tyr Lys Glu Leu Leu Ile Ser Leu Val Ala Ser Leu Phe Met 
    50                  55                  60                  


Gly Phe Gly Val Leu Phe Leu Leu Leu Trp Val Gly Ile Tyr Val 
65                  70                  75                  


<210>  3881
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  3881

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Cys Leu Gly Arg Leu Ser Trp Tyr Asp Pro Asp 
            20                  25                  30          


Phe Gln Ala Arg Leu Thr Arg Ser Asn Ser Lys Cys Gln Gly Gln Leu 
        35                  40                  45              


Glu Val Tyr Leu Lys Asp Gly Trp His Met Val Cys Ser Gln Ser Trp 
    50                  55                  60                  


Gly Arg Ser Ser Lys Gln Trp Glu Asp Pro Ser Gln Ala Ser Lys Val 
65                  70                  75                  80  


Cys Gln Arg Leu Asn Cys Gly Val Pro Leu Ser Leu Gly Pro Phe Leu 
                85                  90                  95      


Val Thr Tyr Thr Pro Gln Ser Ser Ile Ile Cys Tyr Gly Gln Leu Gly 
            100                 105                 110         


Ser Phe Ser Asn Cys Ser His Ser Arg Asn Asp Met Cys His Ser Leu 
        115                 120                 125             


Gly Leu Thr Cys Leu Glu Pro Gln Lys Thr Thr Pro Pro Thr Thr Arg 
    130                 135                 140                 


Pro Pro Pro Thr Thr Thr Pro Glu Pro Thr Ala Pro Pro Arg Leu Gln 
145                 150                 155                 160 


Leu Val Ala Gln Ser Gly Gly Gln His Cys Ala Gly Val Val Glu Phe 
                165                 170                 175     


Tyr Ser Gly Ser Leu Gly Gly Thr Ile Ser Tyr Glu Ala Gln Asp Lys 
            180                 185                 190         


Thr Gln Asp Leu Glu Asn Phe Leu Cys Asn Asn Leu Gln Cys Gly Ser 
        195                 200                 205             


Phe Leu Lys His Leu Pro Glu Thr Glu Ala Gly Arg Ala Gln Asp Pro 
    210                 215                 220                 


Gly Glu Pro Arg Glu His Gln Pro Leu Pro Ile Gln Trp Lys Ile Gln 
225                 230                 235                 240 


Asn Ser Ser Cys Thr Ser Leu Glu His Cys Phe Arg Lys Ile Lys Pro 
                245                 250                 255     


Gln Lys Ser Gly Arg Val Leu Ala Leu Leu Cys Ser Gly Phe Gln Pro 
            260                 265                 270         


Lys Val Gln Ser Arg Leu Val Gly Gly Ser Ser Ile Cys Glu Gly Thr 
        275                 280                 285             


Val Glu Val Arg Gln Gly Ala Gln Trp Ala Ala Leu Cys Asp Ser Ser 
    290                 295                 300                 


Ser Ala Arg Ser Ser Leu Arg Trp Glu Glu Val Cys Arg Glu Gln Gln 
305                 310                 315                 320 


Cys Gly Ser Val Asn Ser Tyr Arg Val Leu Asp Ala Gly Asp Pro Thr 
                325                 330                 335     


Ser Arg Gly Leu Phe Cys Pro His Gln Lys Leu Ser Gln Cys His Glu 
            340                 345                 350         


Leu Trp Glu Arg Asn Ser Tyr Cys Lys Lys Val Phe Val Thr Cys Gln 
        355                 360                 365             


Asp Pro Asn Pro Ala Gly Leu Ala Ala Gly Thr Val Ala Ser Ile Ile 
    370                 375                 380                 


Leu Ala Leu Val Leu Leu Val Val Leu Leu Val Val Cys Gly Pro Leu 
385                 390                 395                 400 


Ala Tyr Lys Lys Leu Val Lys Lys Phe Arg Gln Lys Lys Gln Arg Gln 
                405                 410                 415     


Trp Ile Gly Pro Thr Gly Met Asn Gln Asn Met Ser Phe His Arg Asn 
            420                 425                 430         


His Thr Ala Thr Val Arg Ser His Ala Glu Asn Pro Thr Ala Ser His 
        435                 440                 445             


Val Asp Asn Glu Tyr Ser Gln Pro Pro Arg Asn Ser His Leu Ser Ala 
    450                 455                 460                 


Tyr Pro Ala Leu Glu Gly Ala Leu His Arg Ser Ser Met Gln Pro Asp 
465                 470                 475                 480 


Asn Ser Ser Asp Ser Asp Tyr Asp Leu His Gly Ala Gln Arg Leu 
                485                 490                 495 


<210>  3882
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  3882

Met Pro Thr Asp Met Glu His Thr Gly His Tyr Leu His Leu Ala Phe 
1               5                   10                  15      


Leu Met Thr Thr Val Phe Ser Leu Ser Pro Gly Thr Lys Ala Asn Tyr 
            20                  25                  30          


Thr Arg Leu Trp Ala Asn Ser Thr Ser Ser Trp Asp Ser Val Ile Gln 
        35                  40                  45              


Asn Lys Thr Gly Arg Asn Gln Asn Glu Asn Ile Asn Thr Asn Pro Ile 
    50                  55                  60                  


Thr Pro Glu Val Asp Tyr Lys Gly Asn Ser Thr Asn Met Pro Glu Thr 
65                  70                  75                  80  


Ser His Ile Val Ala Leu Thr Ser Lys Ser Glu Gln Glu Leu Tyr Ile 
                85                  90                  95      


Pro Ser Val Val Ser Asn Ser Pro Ser Thr Val Gln Ser Ile Glu Asn 
            100                 105                 110         


Thr Ser Lys Ser His Gly Glu Ile Phe Lys Lys Asp Val Cys Ala Glu 
        115                 120                 125             


Asn Asn Asn Asn Met Ala Met Leu Ile Cys Leu Ile Ile Ile Ala Val 
    130                 135                 140                 


Leu Phe Leu Ile Cys Thr Phe Leu Phe Leu Ser Thr Val Val Leu Ala 
145                 150                 155                 160 


Asn Lys Val Ser Ser Leu Arg Arg Ser Lys Gln Val Gly Lys Arg Gln 
                165                 170                 175     


Pro Arg Ser Asn Gly Asp Phe Leu Ala Ser Gly Leu Trp Pro Ala Glu 
            180                 185                 190         


Ser Asp Thr Trp Lys Arg Thr Lys Gln Leu Thr Gly Pro Asn Leu Val 
        195                 200                 205             


Met Gln Ser Thr Gly Val Leu Thr Ala Thr Arg Glu Arg Lys Asp Glu 
    210                 215                 220                 


Glu Gly Thr Glu Lys Leu Thr Asn Lys Gln Ile Gly 
225                 230                 235     


<210>  3883
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  3883

Met Asn Tyr Ser Leu His Leu Ala Phe Val Cys Leu Ser Leu Phe Thr 
1               5                   10                  15      


Glu Arg Met Cys Ile Gln Gly Ser Gln Phe Asn Val Glu Val Gly Arg 
            20                  25                  30          


Ser Asp Lys Leu Ser Leu Pro Gly Phe Glu Asn Leu Thr Ala Gly Tyr 
        35                  40                  45              


Asn Lys Phe Leu Arg Pro Asn Phe Gly Gly Glu Pro Val Gln Ile Ala 
    50                  55                  60                  


Leu Thr Leu Asp Ile Ala Ser Ile Ser Ser Ile Ser Glu Ser Asn Met 
65                  70                  75                  80  


Asp Tyr Thr Ala Thr Ile Tyr Leu Arg Gln Arg Trp Met Asp Gln Arg 
                85                  90                  95      


Leu Val Phe Glu Gly Asn Lys Ser Phe Thr Leu Asp Ala Arg Leu Val 
            100                 105                 110         


Glu Phe Leu Trp Val Pro Asp Thr Tyr Ile Val Glu Ser Lys Lys Ser 
        115                 120                 125             


Phe Leu His Glu Val Thr Val Gly Asn Arg Leu Ile Arg Leu Phe Ser 
    130                 135                 140                 


Asn Gly Thr Val Leu Tyr Ala Leu Arg Ile Thr Thr Thr Val Ala Cys 
145                 150                 155                 160 


Asn Met Asp Leu Ser Lys Tyr Pro Met Asp Thr Gln Thr Cys Lys Leu 
                165                 170                 175     


Gln Leu Glu Ser Trp Gly Tyr Asp Gly Asn Asp Val Glu Phe Thr Trp 
            180                 185                 190         


Leu Arg Gly Asn Asp Ser Val Arg Gly Leu Glu His Leu Arg Leu Ala 
        195                 200                 205             


Gln Tyr Thr Ile Glu Arg Tyr Phe Thr Leu Val Thr Arg Ser Gln Gln 
    210                 215                 220                 


Glu Thr Gly Asn Tyr Thr Arg Leu Val Leu Gln Phe Glu Leu Arg Arg 
225                 230                 235                 240 


Asn Val Leu Tyr Phe Ile Leu Glu Thr Tyr Val Pro Ser Thr Phe Leu 
                245                 250                 255     


Val Val Leu Ser Trp Val Ser Phe Trp Ile Ser Leu Asp Ser Val Pro 
            260                 265                 270         


Ala Arg Thr Cys Ile Gly Val Thr Thr Val Leu Ser Met Thr Thr Leu 
        275                 280                 285             


Met Ile Gly Ser Arg Thr Ser Leu Pro Asn Thr Asn Cys Phe Ile Lys 
    290                 295                 300                 


Ala Ile Asp Val Tyr Leu Gly Ile Cys Phe Ser Phe Val Phe Gly Ala 
305                 310                 315                 320 


Leu Leu Glu Tyr Ala Val Ala His Tyr Ser Ser Leu Gln Gln Met Ala 
                325                 330                 335     


Ala Lys Asp Arg Gly Thr Thr Lys Glu Val Glu Glu Val Ser Ile Thr 
            340                 345                 350         


Asn Ile Ile Asn Ser Ser Ile Ser Ser Phe Lys Arg Lys Ile Ser Phe 
        355                 360                 365             


Ala Ser Ile Glu Ile Ser Ser Asp Asn Val Asp Tyr Ser Asp Leu Thr 
    370                 375                 380                 


Met Lys Thr Ser Asp Lys Phe Lys Phe Val Phe Arg Glu Lys Met Gly 
385                 390                 395                 400 


Arg Ile Val Asp Tyr Phe Thr Ile Gln Asn Pro Ser Asn Val Asp His 
                405                 410                 415     


Tyr Ser Lys Leu Leu Phe Pro Leu Ile Phe Met Leu Ala Asn Val Phe 
            420                 425                 430         


Tyr Trp Ala Tyr Tyr Met Tyr Phe 
        435                 440 


<210>  3884
<211>  1297
<212>  PRT
<213>  Homo sapiens

<400>  3884

Met Ala Val Pro Ser Leu Trp Pro Trp Gly Ala Cys Leu Pro Val Ile 
1               5                   10                  15      


Phe Leu Ser Leu Gly Phe Gly Leu Asp Thr Val Glu Val Cys Pro Ser 
            20                  25                  30          


Leu Asp Ile Arg Ser Glu Val Ala Glu Leu Arg Gln Leu Glu Asn Cys 
        35                  40                  45              


Ser Val Val Glu Gly His Leu Gln Ile Leu Leu Met Phe Thr Ala Thr 
    50                  55                  60                  


Gly Glu Asp Phe Arg Gly Leu Ser Phe Pro Arg Leu Thr Gln Val Thr 
65                  70                  75                  80  


Asp Tyr Leu Leu Leu Phe Arg Val Tyr Gly Leu Glu Ser Leu Arg Asp 
                85                  90                  95      


Leu Phe Pro Asn Leu Ala Val Ile Arg Gly Thr Arg Leu Phe Leu Gly 
            100                 105                 110         


Tyr Ala Leu Val Ile Phe Glu Met Pro His Leu Arg Asp Val Ala Leu 
        115                 120                 125             


Pro Ala Leu Gly Ala Val Leu Arg Gly Ala Val Arg Val Glu Lys Asn 
    130                 135                 140                 


Gln Glu Leu Cys His Leu Ser Thr Ile Asp Trp Gly Leu Leu Gln Pro 
145                 150                 155                 160 


Ala Pro Gly Ala Asn His Ile Val Gly Asn Lys Leu Gly Glu Glu Cys 
                165                 170                 175     


Ala Asp Val Cys Pro Gly Val Leu Gly Ala Ala Gly Glu Pro Cys Ala 
            180                 185                 190         


Lys Thr Thr Phe Ser Gly His Thr Asp Tyr Arg Cys Trp Thr Ser Ser 
        195                 200                 205             


His Cys Gln Arg Val Cys Pro Cys Pro His Gly Met Ala Cys Thr Ala 
    210                 215                 220                 


Arg Gly Glu Cys Cys His Thr Glu Cys Leu Gly Gly Cys Ser Gln Pro 
225                 230                 235                 240 


Glu Asp Pro Arg Ala Cys Val Ala Cys Arg His Leu Tyr Phe Gln Gly 
                245                 250                 255     


Ala Cys Leu Trp Ala Cys Pro Pro Gly Thr Tyr Gln Tyr Glu Ser Trp 
            260                 265                 270         


Arg Cys Val Thr Ala Glu Arg Cys Ala Ser Leu His Ser Val Pro Gly 
        275                 280                 285             


Arg Ala Ser Thr Phe Gly Ile His Gln Gly Ser Cys Leu Ala Gln Cys 
    290                 295                 300                 


Pro Ser Gly Phe Thr Arg Asn Ser Ser Ser Ile Phe Cys His Lys Cys 
305                 310                 315                 320 


Glu Gly Leu Cys Pro Lys Glu Cys Lys Val Gly Thr Lys Thr Ile Asp 
                325                 330                 335     


Ser Ile Gln Ala Ala Gln Asp Leu Val Gly Cys Thr His Val Glu Gly 
            340                 345                 350         


Ser Leu Ile Leu Asn Leu Arg Gln Gly Tyr Asn Leu Glu Pro Gln Leu 
        355                 360                 365             


Gln His Ser Leu Gly Leu Val Glu Thr Ile Thr Gly Phe Leu Lys Ile 
    370                 375                 380                 


Lys His Ser Phe Ala Leu Val Ser Leu Gly Phe Phe Lys Asn Leu Lys 
385                 390                 395                 400 


Leu Ile Arg Gly Asp Ala Met Val Asp Gly Asn Tyr Thr Leu Tyr Val 
                405                 410                 415     


Leu Asp Asn Gln Asn Leu Gln Gln Leu Gly Ser Trp Val Ala Ala Gly 
            420                 425                 430         


Leu Thr Ile Pro Val Gly Lys Ile Tyr Phe Ala Phe Asn Pro Arg Leu 
        435                 440                 445             


Cys Leu Glu His Ile Tyr Arg Leu Glu Glu Val Thr Gly Thr Arg Gly 
    450                 455                 460                 


Arg Gln Asn Lys Ala Glu Ile Asn Pro Arg Thr Asn Gly Asp Arg Ala 
465                 470                 475                 480 


Ala Cys Gln Thr Arg Thr Leu Arg Phe Val Ser Asn Val Thr Glu Ala 
                485                 490                 495     


Asp Arg Ile Leu Leu Arg Trp Glu Arg Tyr Glu Pro Leu Glu Ala Arg 
            500                 505                 510         


Asp Leu Leu Ser Phe Ile Val Tyr Tyr Lys Glu Ser Pro Phe Gln Asn 
        515                 520                 525             


Ala Thr Glu His Val Gly Pro Asp Ala Cys Gly Thr Gln Ser Trp Asn 
    530                 535                 540                 


Leu Leu Asp Val Glu Leu Pro Leu Ser Arg Thr Gln Glu Pro Gly Val 
545                 550                 555                 560 


Thr Leu Ala Ser Leu Lys Pro Trp Thr Gln Tyr Ala Val Phe Val Arg 
                565                 570                 575     


Ala Ile Thr Leu Thr Thr Glu Glu Asp Ser Pro His Gln Gly Ala Gln 
            580                 585                 590         


Ser Pro Ile Val Tyr Leu Arg Thr Leu Pro Ala Ala Pro Thr Val Pro 
        595                 600                 605             


Gln Asp Val Ile Ser Thr Ser Asn Ser Ser Ser His Leu Leu Val Arg 
    610                 615                 620                 


Trp Lys Pro Pro Thr Gln Arg Asn Gly Asn Leu Thr Tyr Tyr Leu Val 
625                 630                 635                 640 


Leu Trp Gln Arg Leu Ala Glu Asp Gly Asp Leu Tyr Leu Asn Asp Tyr 
                645                 650                 655     


Cys His Arg Gly Leu Arg Leu Pro Thr Ser Asn Asn Asp Pro Arg Phe 
            660                 665                 670         


Asp Gly Glu Asp Gly Asp Pro Glu Ala Glu Met Glu Ser Asp Cys Cys 
        675                 680                 685             


Pro Cys Gln His Pro Pro Pro Gly Gln Val Leu Pro Pro Leu Glu Ala 
    690                 695                 700                 


Gln Glu Ala Ser Phe Gln Lys Lys Phe Glu Asn Phe Leu His Asn Ala 
705                 710                 715                 720 


Ile Thr Ile Pro Ile Ser Pro Trp Lys Val Thr Ser Ile Asn Lys Ser 
                725                 730                 735     


Pro Gln Arg Asp Ser Gly Arg His Arg Arg Ala Ala Gly Pro Leu Arg 
            740                 745                 750         


Leu Gly Gly Asn Ser Ser Asp Phe Glu Ile Gln Glu Asp Lys Val Pro 
        755                 760                 765             


Arg Glu Arg Ala Val Leu Ser Gly Leu Arg His Phe Thr Glu Tyr Arg 
    770                 775                 780                 


Ile Asp Ile His Ala Cys Asn His Ala Ala His Thr Val Gly Cys Ser 
785                 790                 795                 800 


Ala Ala Thr Phe Val Phe Ala Arg Thr Met Pro His Arg Glu Ala Asp 
                805                 810                 815     


Gly Ile Pro Gly Lys Val Ala Trp Glu Ala Ser Ser Lys Asn Ser Val 
            820                 825                 830         


Leu Leu Arg Trp Leu Glu Pro Pro Asp Pro Asn Gly Leu Ile Leu Lys 
        835                 840                 845             


Tyr Glu Ile Lys Tyr Arg Arg Leu Gly Glu Glu Ala Thr Val Leu Cys 
    850                 855                 860                 


Val Ser Arg Leu Arg Tyr Ala Lys Phe Gly Gly Val His Leu Ala Leu 
865                 870                 875                 880 


Leu Pro Pro Gly Asn Tyr Ser Ala Arg Val Arg Ala Thr Ser Leu Ala 
                885                 890                 895     


Gly Asn Gly Ser Trp Thr Asp Ser Val Ala Phe Tyr Ile Leu Gly Pro 
            900                 905                 910         


Glu Glu Glu Asp Ala Gly Gly Leu His Val Leu Leu Thr Ala Thr Pro 
        915                 920                 925             


Val Gly Leu Thr Leu Leu Ile Val Leu Ala Ala Leu Gly Phe Phe Tyr 
    930                 935                 940                 


Gly Lys Lys Arg Asn Arg Thr Leu Tyr Ala Ser Val Asn Pro Glu Tyr 
945                 950                 955                 960 


Phe Ser Ala Ser Asp Met Tyr Val Pro Asp Glu Trp Glu Val Pro Arg 
                965                 970                 975     


Glu Gln Ile Ser Ile Ile Arg Glu Leu Gly Gln Gly Ser Phe Gly Met 
            980                 985                 990         


Val Tyr Glu Gly Leu Ala Arg Gly  Leu Glu Ala Gly Glu  Glu Ser Thr 
        995                 1000                 1005             


Pro Val  Ala Leu Lys Thr Val  Asn Glu Leu Ala Ser  Pro Arg Glu 
    1010                 1015                 1020             


Cys Ile  Glu Phe Leu Lys Glu  Ala Ser Val Met Lys  Ala Phe Lys 
    1025                 1030                 1035             


Cys His  His Val Val Arg Leu  Leu Gly Val Val Ser  Gln Gly Gln 
    1040                 1045                 1050             


Pro Thr  Leu Val Ile Met Glu  Leu Met Thr Arg Gly  Asp Leu Lys 
    1055                 1060                 1065             


Ser His  Leu Arg Ser Leu Arg  Pro Glu Ala Glu Asn  Asn Pro Gly 
    1070                 1075                 1080             


Leu Pro  Gln Pro Ala Leu Gly  Glu Met Ile Gln Met  Ala Gly Glu 
    1085                 1090                 1095             


Ile Ala  Asp Gly Met Ala Tyr  Leu Ala Ala Asn Lys  Phe Val His 
    1100                 1105                 1110             


Arg Asp  Leu Ala Ala Arg Asn  Cys Met Val Ser Gln  Asp Phe Thr 
    1115                 1120                 1125             


Val Lys  Ile Gly Asp Phe Gly  Met Thr Arg Asp Val  Tyr Glu Thr 
    1130                 1135                 1140             


Asp Tyr  Tyr Arg Lys Gly Gly  Lys Gly Leu Leu Pro  Val Arg Trp 
    1145                 1150                 1155             


Met Ala  Pro Glu Ser Leu Lys  Asp Gly Ile Phe Thr  Thr His Ser 
    1160                 1165                 1170             


Asp Val  Trp Ser Phe Gly Val  Val Leu Trp Glu Ile  Val Thr Leu 
    1175                 1180                 1185             


Ala Glu  Gln Pro Tyr Gln Gly  Leu Ser Asn Glu Gln  Val Leu Lys 
    1190                 1195                 1200             


Phe Val  Met Asp Gly Gly Val  Leu Glu Glu Leu Glu  Gly Cys Pro 
    1205                 1210                 1215             


Leu Gln  Leu Gln Glu Leu Met  Ser Arg Cys Trp Gln  Pro Asn Pro 
    1220                 1225                 1230             


Arg Leu  Arg Pro Ser Phe Thr  His Ile Leu Asp Ser  Ile Gln Glu 
    1235                 1240                 1245             


Glu Leu  Arg Pro Ser Phe Arg  Leu Leu Ser Phe Tyr  Tyr Ser Pro 
    1250                 1255                 1260             


Glu Cys  Arg Gly Ala Arg Gly  Ser Leu Pro Thr Thr  Asp Ala Glu 
    1265                 1270                 1275             


Pro Asp  Ser Ser Pro Thr Pro  Arg Asp Cys Ser Pro  Gln Asn Gly 
    1280                 1285                 1290             


Gly Pro  Gly His 
    1295         


<210>  3885
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  3885

Met Ala Ala Pro Asp Leu Leu Asp Pro Lys Ser Ala Ala Gln Asn Ser 
1               5                   10                  15      


Lys Pro Arg Leu Ser Phe Ser Thr Lys Pro Thr Val Leu Ala Ser Arg 
            20                  25                  30          


Val Glu Ser Asp Thr Thr Ile Asn Val Met Lys Trp Lys Thr Val Ser 
        35                  40                  45              


Thr Ile Phe Leu Val Val Val Leu Tyr Leu Ile Ile Gly Ala Thr Val 
    50                  55                  60                  


Phe Lys Ala Leu Glu Gln Pro His Glu Ile Ser Gln Arg Thr Thr Ile 
65                  70                  75                  80  


Val Ile Gln Lys Gln Thr Phe Ile Ser Gln His Ser Cys Val Asn Ser 
                85                  90                  95      


Thr Glu Leu Asp Glu Leu Ile Gln Gln Ile Val Ala Ala Ile Asn Ala 
            100                 105                 110         


Gly Ile Ile Pro Leu Gly Asn Thr Ser Asn Gln Ile Ser His Trp Asp 
        115                 120                 125             


Leu Gly Ser Ser Phe Phe Phe Ala Gly Thr Val Ile Thr Thr Ile Gly 
    130                 135                 140                 


Phe Gly Asn Ile Ser Pro Arg Thr Glu Gly Gly Lys Ile Phe Cys Ile 
145                 150                 155                 160 


Ile Tyr Ala Leu Leu Gly Ile Pro Leu Phe Gly Phe Leu Leu Ala Gly 
                165                 170                 175     


Val Gly Asp Gln Leu Gly Thr Ile Phe Gly Lys Gly Ile Ala Lys Val 
            180                 185                 190         


Glu Asp Thr Phe Ile Lys Trp Asn Val Ser Gln Thr Lys Ile Arg Ile 
        195                 200                 205             


Ile Ser Thr Ile Ile Phe Ile Leu Phe Gly Cys Val Leu Phe Val Ala 
    210                 215                 220                 


Leu Pro Ala Ile Ile Phe Lys His Ile Glu Gly Trp Ser Ala Leu Asp 
225                 230                 235                 240 


Ala Ile Tyr Phe Val Val Ile Thr Leu Thr Thr Ile Gly Phe Gly Asp 
                245                 250                 255     


Tyr Val Ala Gly Gly Ser Asp Ile Glu Tyr Leu Asp Phe Tyr Lys Pro 
            260                 265                 270         


Val Val Trp Phe Trp Ile Leu Val Gly Leu Ala Tyr Phe Ala Ala Val 
        275                 280                 285             


Leu Ser Met Ile Gly Asp Trp Leu Arg Val Ile Ser Lys Lys Thr Lys 
    290                 295                 300                 


Glu Glu Val Gly Glu Phe Arg Ala His Ala Ala Glu Trp Thr Ala Asn 
305                 310                 315                 320 


Val Thr Ala Glu Phe Lys Glu Thr Arg Arg Arg Leu Ser Val Glu Ile 
                325                 330                 335     


Tyr Asp Lys Phe Gln Arg Ala Thr Ser Ile Lys Arg Lys Leu Ser Ala 
            340                 345                 350         


Glu Leu Ala Gly Asn His Asn Gln Glu Leu Thr Pro Cys Arg Arg Thr 
        355                 360                 365             


Leu Ser Val Asn His Leu Thr Ser Glu Arg Asp Val Leu Pro Pro Leu 
    370                 375                 380                 


Leu Lys Thr Glu Ser Ile Tyr Leu Asn Gly Leu Thr Pro His Cys Ala 
385                 390                 395                 400 


Gly Glu Glu Ile Ala Val Ile Glu Asn Ile Lys 
                405                 410     


<210>  3886
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  3886

Met Ser Leu Leu Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro His Glu Gly Val His Arg Lys Pro Ser Leu Leu 
            20                  25                  30          


Ala His Pro Gly Arg Leu Val Lys Ser Glu Glu Thr Val Ile Leu Gln 
        35                  40                  45              


Cys Trp Ser Asp Val Met Phe Glu His Phe Leu Leu His Arg Glu Gly 
    50                  55                  60                  


Met Phe Asn Asp Thr Leu Arg Leu Ile Gly Glu His His Asp Gly Val 
65                  70                  75                  80  


Ser Lys Ala Asn Phe Ser Ile Ser Arg Met Thr Gln Asp Leu Ala Gly 
                85                  90                  95      


Thr Tyr Arg Cys Tyr Gly Ser Val Thr His Ser Pro Tyr Gln Val Ser 
            100                 105                 110         


Ala Pro Ser Asp Pro Leu Asp Ile Val Ile Ile Gly Leu Tyr Glu Lys 
        115                 120                 125             


Pro Ser Leu Ser Ala Gln Leu Gly Pro Thr Val Leu Ala Gly Glu Asn 
    130                 135                 140                 


Val Thr Leu Ser Cys Ser Ser Arg Ser Ser Tyr Asp Met Tyr His Leu 
145                 150                 155                 160 


Ser Arg Glu Gly Glu Ala His Glu Arg Arg Leu Pro Ala Gly Pro Lys 
                165                 170                 175     


Val Asn Gly Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His 
            180                 185                 190         


Gly Gly Thr Tyr Arg Cys Phe Gly Ser Phe His Asp Ser Pro Tyr Glu 
        195                 200                 205             


Trp Ser Lys Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro 
    210                 215                 220                 


Ser Asn Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Thr Gly Asn 
225                 230                 235                 240 


Pro Arg His Leu His Ile Leu Ile Gly Thr Ser Val Val Ile Ile Leu 
                245                 250                 255     


Phe Ile Leu Leu Phe Phe Leu Leu His Arg Trp Cys Ser Asn Lys Lys 
            260                 265                 270         


Asn Ala Ala Val Met Asp Gln Glu Ser Ala Gly Asn Arg Thr Ala Asn 
        275                 280                 285             


Ser Glu Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Thr Gln 
    290                 295                 300                 


Leu Asn His Cys Val Phe Thr Gln Arg Lys Ile Thr Arg Pro Ser Gln 
305                 310                 315                 320 


Arg Pro Lys Thr Pro Pro Thr Asp Ile Ile Val Tyr Thr Glu Leu Pro 
                325                 330                 335     


Asn Ala Glu Ser Arg Ser Lys Val Val Ser Cys Pro 
            340                 345             


<210>  3887
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  3887

Met Ser Leu Met Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro His Glu Gly Val His Arg Lys Pro Ser Leu Leu 
            20                  25                  30          


Ala His Pro Gly Arg Leu Val Lys Ser Glu Glu Thr Val Ile Leu Gln 
        35                  40                  45              


Cys Trp Ser Asp Val Arg Phe Glu His Phe Leu Leu His Arg Glu Gly 
    50                  55                  60                  


Lys Phe Lys Asp Thr Leu His Leu Ile Gly Glu His His Asp Gly Val 
65                  70                  75                  80  


Ser Lys Ala Asn Phe Ser Ile Gly Pro Met Met Gln Asp Leu Ala Gly 
                85                  90                  95      


Thr Tyr Arg Cys Tyr Gly Ser Val Thr His Ser Pro Tyr Gln Leu Ser 
            100                 105                 110         


Ala Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys 
        115                 120                 125             


Pro Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Leu Ala Gly Glu Ser 
    130                 135                 140                 


Val Thr Leu Ser Cys Ser Ser Arg Ser Ser Tyr Asp Met Tyr His Leu 
145                 150                 155                 160 


Ser Arg Glu Gly Glu Ala His Glu Cys Arg Phe Ser Ala Gly Pro Lys 
                165                 170                 175     


Val Asn Gly Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His 
            180                 185                 190         


Gly Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Asp Ser Pro Tyr Glu 
        195                 200                 205             


Trp Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro 
    210                 215                 220                 


Ser Asn Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Thr Gly Asn 
225                 230                 235                 240 


Pro Arg His Leu His Ile Leu Ile Gly Thr Ser Val Val Ile Ile Leu 
                245                 250                 255     


Phe Ile Leu Leu Phe Phe Leu Leu His Arg Trp Cys Ser Asn Lys Lys 
            260                 265                 270         


Asn Ala Ala Val Met Asp Gln Glu Ser Ala Gly Asn Arg Thr Ala Asn 
        275                 280                 285             


Ser Glu Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Thr Gln 
    290                 295                 300                 


Leu Asn His Cys Val Phe Thr Gln Arg Lys Ile Thr Arg Pro Ser Gln 
305                 310                 315                 320 


Arg Pro Lys Thr Pro Pro Thr Asp Ile Ile Val Tyr Thr Glu Leu Pro 
                325                 330                 335     


Asn Ala Glu Ser Arg Ser Lys Val Val Ser Cys Pro 
            340                 345             


<210>  3888
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  3888

Met Cys Tyr Gly Lys Cys Ala Arg Cys Ile Gly His Ser Leu Val Gly 
1               5                   10                  15      


Leu Ala Leu Leu Cys Ile Ala Ala Asn Ile Leu Leu Tyr Phe Pro Asn 
            20                  25                  30          


Gly Glu Thr Lys Tyr Ala Ser Glu Asn His Leu Ser Arg Phe Val Trp 
        35                  40                  45              


Phe Phe Ser Gly Ile Val Gly Gly Gly Leu Leu Met Leu Leu Pro Ala 
    50                  55                  60                  


Phe Val Phe Ile Gly Leu Glu Gln Asp Asp Cys Cys Gly Cys Cys Gly 
65                  70                  75                  80  


His Glu Asn Cys Gly Lys Arg Cys Ala Met Leu Ser Ser Val Leu Ala 
                85                  90                  95      


Ala Leu Ile Gly Ile Ala Gly Ser Gly Tyr Cys Val Ile Val Ala Ala 
            100                 105                 110         


Leu Gly Leu Ala Glu Gly Pro Leu Cys Leu Asp Ser Leu Gly Gln Trp 
        115                 120                 125             


Asn Tyr Thr Phe Ala Ser Thr Glu Gly Gln Tyr Leu Leu Asp Thr Ser 
    130                 135                 140                 


Thr Trp Ser Glu Cys Thr Glu Pro Lys His Ile Val Glu Trp Asn Val 
145                 150                 155                 160 


Ser Leu Phe Ser Ile Leu Leu Ala Leu Gly Gly Ile Glu Phe Ile Leu 
                165                 170                 175     


Cys Leu Ile Gln Val Ile Asn Gly Val Leu Gly Gly Ile Cys Gly Phe 
            180                 185                 190         


Cys Cys Ser His Gln Gln Gln Tyr Asp Cys 
        195                 200         


<210>  3889
<211>  659
<212>  PRT
<213>  Homo sapiens

<400>  3889

Met Ala Ser Thr Val Ser Pro Ser Thr Ile Ala Glu Thr Pro Glu Pro 
1               5                   10                  15      


Pro Pro Leu Ser Asp His Ile Arg Asn Ala Ala Asp Ile Ser Val Ile 
            20                  25                  30          


Val Ile Tyr Phe Leu Val Val Met Ala Val Gly Leu Trp Ala Met Leu 
        35                  40                  45              


Lys Thr Asn Arg Gly Thr Ile Gly Gly Phe Phe Leu Ala Gly Arg Asp 
    50                  55                  60                  


Met Ala Trp Trp Pro Met Gly Ala Ser Leu Phe Ala Ser Asn Ile Gly 
65                  70                  75                  80  


Ser Asn His Tyr Val Gly Leu Ala Gly Thr Gly Ala Ala Ser Gly Val 
                85                  90                  95      


Ala Thr Val Thr Phe Glu Trp Thr Ser Ser Val Met Leu Leu Ile Leu 
            100                 105                 110         


Gly Trp Ile Phe Val Pro Ile Tyr Ile Lys Ser Gly Val Met Thr Met 
        115                 120                 125             


Pro Glu Tyr Leu Lys Lys Arg Phe Gly Gly Glu Arg Leu Gln Val Tyr 
    130                 135                 140                 


Leu Ser Ile Leu Ser Leu Phe Ile Cys Val Val Leu Leu Ile Ser Ala 
145                 150                 155                 160 


Asp Ile Phe Ala Gly Ala Ile Phe Ile Lys Leu Ala Leu Gly Leu Asp 
                165                 170                 175     


Leu Tyr Leu Ala Ile Phe Ile Leu Leu Ala Met Thr Ala Val Tyr Thr 
            180                 185                 190         


Thr Thr Gly Gly Leu Ala Ser Val Ile Tyr Thr Asp Thr Leu Gln Thr 
        195                 200                 205             


Ile Ile Met Leu Ile Gly Ser Phe Ile Leu Met Gly Phe Ala Phe Asn 
    210                 215                 220                 


Glu Val Gly Gly Tyr Glu Ser Phe Thr Glu Lys Tyr Val Asn Ala Thr 
225                 230                 235                 240 


Pro Ser Val Val Glu Gly Asp Asn Leu Thr Ile Ser Ala Ser Cys Tyr 
                245                 250                 255     


Thr Pro Arg Ala Asp Ser Phe His Ile Phe Arg Asp Ala Val Thr Gly 
            260                 265                 270         


Asp Ile Pro Trp Pro Gly Ile Ile Phe Gly Met Pro Ile Thr Ala Leu 
        275                 280                 285             


Trp Tyr Trp Cys Thr Asn Gln Val Ile Val Gln Arg Cys Leu Cys Gly 
    290                 295                 300                 


Lys Asp Met Ser His Val Lys Ala Ala Cys Ile Met Cys Ala Tyr Leu 
305                 310                 315                 320 


Lys Leu Leu Pro Met Phe Leu Met Val Met Pro Gly Met Ile Ser Arg 
                325                 330                 335     


Ile Leu Tyr Thr Asp Met Val Ala Cys Val Val Pro Ser Glu Cys Val 
            340                 345                 350         


Lys His Cys Gly Val Asp Val Gly Cys Thr Asn Tyr Ala Tyr Pro Thr 
        355                 360                 365             


Met Val Leu Glu Leu Met Pro Gln Gly Leu Arg Gly Leu Met Leu Ser 
    370                 375                 380                 


Val Met Leu Ala Ser Leu Met Ser Ser Leu Thr Ser Ile Phe Asn Ser 
385                 390                 395                 400 


Ala Ser Thr Leu Phe Thr Ile Asp Leu Tyr Thr Lys Met Arg Lys Gln 
                405                 410                 415     


Ala Ser Glu Lys Glu Leu Leu Ile Ala Gly Arg Ile Phe Val Leu Leu 
            420                 425                 430         


Leu Thr Val Val Ser Ile Val Trp Val Pro Leu Val Gln Val Ser Gln 
        435                 440                 445             


Asn Gly Gln Leu Ile His Tyr Thr Glu Ser Ile Ser Ser Tyr Leu Gly 
    450                 455                 460                 


Pro Pro Ile Ala Ala Val Phe Val Leu Ala Ile Phe Cys Lys Arg Val 
465                 470                 475                 480 


Asn Glu Gln Gly Ala Phe Trp Gly Leu Met Val Gly Leu Ala Met Gly 
                485                 490                 495     


Leu Ile Arg Met Ile Thr Glu Phe Ala Tyr Gly Thr Gly Ser Cys Leu 
            500                 505                 510         


Ala Pro Ser Asn Cys Pro Lys Ile Ile Cys Gly Val His Tyr Leu Tyr 
        515                 520                 525             


Phe Ser Ile Val Leu Phe Phe Gly Ser Met Leu Val Thr Leu Gly Ile 
    530                 535                 540                 


Ser Leu Leu Thr Lys Pro Ile Pro Asp Val His Leu Tyr Arg Leu Cys 
545                 550                 555                 560 


Trp Val Leu Arg Asn Ser Thr Glu Glu Arg Ile Asp Ile Asp Ala Glu 
                565                 570                 575     


Glu Lys Ser Gln Glu Glu Thr Asp Asp Gly Val Glu Glu Asp Tyr Pro 
            580                 585                 590         


Glu Lys Ser Arg Gly Cys Leu Lys Lys Ala Tyr Asp Leu Phe Cys Gly 
        595                 600                 605             


Leu Gln Lys Gly Pro Lys Leu Thr Lys Glu Glu Glu Glu Ala Leu Ser 
    610                 615                 620                 


Lys Lys Leu Thr Asp Thr Ser Glu Arg Pro Ser Trp Arg Thr Ile Val 
625                 630                 635                 640 


Asn Ile Asn Ala Ile Leu Leu Leu Ala Val Val Val Phe Ile His Gly 
                645                 650                 655     


Tyr Tyr Ala 
            


<210>  3890
<211>  632
<212>  PRT
<213>  Homo sapiens

<400>  3890

Met Thr Ala Glu Lys Ala Leu Pro Leu Gly Asn Gly Lys Ala Ala Glu 
1               5                   10                  15      


Glu Ala Arg Glu Ser Glu Ala Pro Gly Gly Gly Cys Ser Ser Gly Gly 
            20                  25                  30          


Ala Ala Pro Ala Arg His Pro Arg Val Lys Arg Asp Lys Ala Val His 
        35                  40                  45              


Glu Arg Gly His Trp Asn Asn Lys Val Glu Phe Val Leu Ser Val Ala 
    50                  55                  60                  


Gly Glu Ile Ile Gly Leu Gly Asn Val Trp Arg Phe Pro Tyr Leu Cys 
65                  70                  75                  80  


Tyr Lys Asn Gly Gly Gly Ala Phe Leu Ile Pro Tyr Val Val Phe Phe 
                85                  90                  95      


Ile Cys Cys Gly Ile Pro Val Phe Phe Leu Glu Thr Ala Leu Gly Gln 
            100                 105                 110         


Phe Thr Ser Glu Gly Gly Ile Thr Cys Trp Arg Lys Val Cys Pro Leu 
        115                 120                 125             


Phe Glu Gly Ile Gly Tyr Ala Thr Gln Val Ile Glu Ala His Leu Asn 
    130                 135                 140                 


Val Tyr Tyr Ile Ile Ile Leu Ala Trp Ala Ile Phe Tyr Leu Ser Asn 
145                 150                 155                 160 


Cys Phe Thr Thr Glu Leu Pro Trp Ala Thr Cys Gly His Glu Trp Asn 
                165                 170                 175     


Thr Glu Asn Cys Val Glu Phe Gln Lys Leu Asn Val Ser Asn Tyr Ser 
            180                 185                 190         


His Val Ser Leu Gln Asn Ala Thr Ser Pro Val Met Glu Phe Trp Glu 
        195                 200                 205             


His Arg Val Leu Ala Ile Ser Asp Gly Ile Glu His Ile Gly Asn Leu 
    210                 215                 220                 


Arg Trp Glu Leu Ala Leu Cys Leu Leu Ala Ala Trp Thr Ile Cys Tyr 
225                 230                 235                 240 


Phe Cys Ile Trp Lys Gly Thr Lys Ser Thr Gly Lys Val Val Tyr Val 
                245                 250                 255     


Thr Ala Thr Phe Pro Tyr Ile Met Leu Leu Ile Leu Leu Ile Arg Gly 
            260                 265                 270         


Val Thr Leu Pro Gly Ala Ser Glu Gly Ile Lys Phe Tyr Leu Tyr Pro 
        275                 280                 285             


Asp Leu Ser Arg Leu Ser Asp Pro Gln Val Trp Val Asp Ala Gly Thr 
    290                 295                 300                 


Gln Ile Phe Phe Ser Tyr Ala Ile Cys Leu Gly Cys Leu Thr Ala Leu 
305                 310                 315                 320 


Gly Ser Tyr Asn Asn Tyr Asn Asn Asn Cys Tyr Arg Asp Cys Ile Met 
                325                 330                 335     


Leu Cys Cys Leu Asn Ser Gly Thr Ser Phe Val Ala Gly Phe Ala Ile 
            340                 345                 350         


Phe Ser Val Leu Gly Phe Met Ala Tyr Glu Gln Gly Val Pro Ile Ala 
        355                 360                 365             


Glu Val Ala Glu Ser Gly Pro Gly Leu Ala Phe Ile Ala Tyr Pro Lys 
    370                 375                 380                 


Ala Val Thr Met Met Pro Leu Ser Pro Leu Trp Ala Thr Leu Phe Phe 
385                 390                 395                 400 


Met Met Leu Ile Phe Leu Gly Leu Asp Ser Gln Phe Val Cys Val Glu 
                405                 410                 415     


Ser Leu Val Thr Ala Val Val Asp Met Tyr Pro Lys Val Phe Arg Arg 
            420                 425                 430         


Gly Tyr Arg Arg Glu Leu Leu Ile Leu Ala Leu Ser Val Ile Ser Tyr 
        435                 440                 445             


Phe Leu Gly Leu Val Met Leu Thr Glu Gly Gly Met Tyr Ile Phe Gln 
    450                 455                 460                 


Leu Phe Asp Ser Tyr Ala Ala Ser Gly Met Cys Leu Leu Phe Val Ala 
465                 470                 475                 480 


Ile Phe Glu Cys Ile Cys Ile Gly Trp Val Tyr Gly Ser Asn Arg Phe 
                485                 490                 495     


Tyr Asp Asn Ile Glu Asp Met Ile Gly Tyr Arg Pro Pro Ser Leu Ile 
            500                 505                 510         


Lys Trp Cys Trp Met Ile Met Thr Pro Gly Ile Cys Ala Gly Ile Phe 
        515                 520                 525             


Ile Phe Phe Leu Ile Lys Tyr Lys Pro Leu Lys Tyr Asn Asn Ile Tyr 
    530                 535                 540                 


Thr Tyr Pro Ala Trp Gly Tyr Gly Ile Gly Trp Leu Met Ala Leu Ser 
545                 550                 555                 560 


Ser Met Leu Cys Ile Pro Leu Trp Ile Cys Ile Thr Val Trp Lys Thr 
                565                 570                 575     


Glu Gly Thr Leu Pro Glu Lys Leu Gln Lys Leu Thr Thr Pro Ser Thr 
            580                 585                 590         


Asp Leu Lys Met Arg Gly Lys Leu Gly Val Ser Pro Arg Met Val Thr 
        595                 600                 605             


Val Asn Asp Cys Asp Ala Lys Leu Lys Ser Asp Gly Thr Ile Ala Ala 
    610                 615                 620                 


Ile Thr Glu Lys Glu Thr His Phe 
625                 630         


<210>  3891
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  3891

Met Ser Ala Pro Ala Gln Pro Pro Ala Glu Gly Thr Glu Gly Thr Ala 
1               5                   10                  15      


Pro Gly Gly Gly Pro Pro Gly Pro Pro Pro Asn Met Thr Ser Asn Arg 
            20                  25                  30          


Arg Leu Gln Gln Thr Gln Ala Gln Val Glu Glu Val Val Asp Ile Ile 
        35                  40                  45              


Arg Val Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu 
    50                  55                  60                  


Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu 
65                  70                  75                  80  


Ser Ser Ala Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Cys Lys 
                85                  90                  95      


Met Met Ile Met Leu Gly Ala Ile Cys Ala Ile Ile Val Val Val Ile 
            100                 105                 110         


Val Ile Tyr Phe Phe Thr 
        115             


<210>  3892
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  3892

Met Ser Ala Thr Ala Ala Thr Ala Pro Pro Ala Ala Pro Ala Gly Glu 
1               5                   10                  15      


Gly Gly Pro Pro Ala Pro Pro Pro Asn Leu Thr Ser Asn Arg Arg Leu 
            20                  25                  30          


Gln Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met Arg Val 
        35                  40                  45              


Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp 
    50                  55                  60                  


Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser 
65                  70                  75                  80  


Ala Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Leu Lys Met Met 
                85                  90                  95      


Ile Ile Leu Gly Val Ile Cys Ala Ile Ile Leu Ile Ile Ile Ile Val 
            100                 105                 110         


Tyr Phe Ser Thr 
        115     


<210>  3893
<211>  739
<212>  PRT
<213>  Homo sapiens

<400>  3893

Met Phe Leu Leu Leu Ala Leu Leu Thr Glu Leu Gly Arg Leu Gln Ala 
1               5                   10                  15      


His Glu Gly Ser Glu Gly Ile Phe Leu His Val Thr Val Pro Arg Lys 
            20                  25                  30          


Ile Lys Ser Asn Asp Ser Glu Val Ser Glu Arg Lys Met Ile Tyr Ile 
        35                  40                  45              


Ile Thr Ile Asp Gly Gln Pro Tyr Thr Leu His Leu Gly Lys Gln Ser 
    50                  55                  60                  


Phe Leu Pro Gln Asn Phe Leu Val Tyr Thr Tyr Asn Glu Thr Gly Ser 
65                  70                  75                  80  


Leu His Ser Val Ser Pro Tyr Phe Met Met His Cys His Tyr Gln Gly 
                85                  90                  95      


Tyr Ala Ala Glu Phe Pro Asn Ser Phe Val Thr Leu Ser Ile Cys Ser 
            100                 105                 110         


Gly Leu Arg Gly Phe Leu Gln Phe Glu Asn Ile Ser Tyr Gly Ile Glu 
        115                 120                 125             


Pro Val Glu Ser Ser Ala Arg Phe Glu His Ile Ile Tyr Gln Met Lys 
    130                 135                 140                 


Asn Asn Asp Pro Asn Val Ser Ile Leu Ala Val Asn Tyr Ser His Ile 
145                 150                 155                 160 


Trp Gln Lys Asp Gln Pro Tyr Lys Val Pro Leu Asn Ser Gln Ile Lys 
                165                 170                 175     


Asn Leu Ser Lys Leu Leu Pro Gln Tyr Leu Glu Ile Tyr Ile Ile Val 
            180                 185                 190         


Glu Lys Ala Leu Tyr Asp Tyr Met Gly Ser Glu Met Met Ala Val Thr 
        195                 200                 205             


Gln Lys Ile Val Gln Val Ile Gly Leu Val Asn Thr Met Phe Thr Gln 
    210                 215                 220                 


Phe Lys Leu Thr Val Ile Leu Ser Ser Leu Glu Leu Trp Ser Asn Glu 
225                 230                 235                 240 


Asn Gln Ile Ser Thr Ser Gly Asp Ala Asp Asp Ile Leu Gln Arg Phe 
                245                 250                 255     


Leu Ala Trp Lys Arg Asp Tyr Leu Ile Leu Arg Pro His Asp Ile Ala 
            260                 265                 270         


Tyr Leu Leu Val Tyr Arg Lys His Pro Lys Tyr Val Gly Ala Thr Phe 
        275                 280                 285             


Pro Gly Thr Val Cys Asn Lys Ser Tyr Asp Ala Gly Ile Ala Met Tyr 
    290                 295                 300                 


Pro Asp Ala Ile Gly Leu Glu Gly Phe Ser Val Ile Ile Ala Gln Leu 
305                 310                 315                 320 


Leu Gly Leu Asn Val Gly Leu Thr Tyr Asp Asp Ile Thr Gln Cys Phe 
                325                 330                 335     


Cys Leu Arg Ala Thr Cys Ile Met Asn His Glu Ala Val Ser Ala Ser 
            340                 345                 350         


Gly Arg Lys Ile Phe Ser Asn Cys Ser Met His Asp Tyr Arg Tyr Phe 
        355                 360                 365             


Val Ser Lys Phe Glu Thr Lys Cys Leu Gln Lys Leu Ser Asn Leu Gln 
    370                 375                 380                 


Pro Leu His Gln Asn Gln Pro Val Cys Gly Asn Gly Ile Leu Glu Ser 
385                 390                 395                 400 


Asn Glu Glu Cys Asp Cys Gly Asn Lys Asn Glu Cys Gln Phe Lys Lys 
                405                 410                 415     


Cys Cys Asp Tyr Asn Thr Cys Lys Leu Lys Gly Ser Val Lys Cys Gly 
            420                 425                 430         


Ser Gly Pro Cys Cys Thr Ser Lys Cys Glu Leu Ser Ile Ala Gly Thr 
        435                 440                 445             


Pro Cys Arg Lys Ser Ile Asp Pro Glu Cys Asp Phe Thr Glu Tyr Cys 
    450                 455                 460                 


Asn Gly Thr Ser Ser Asn Cys Val Pro Asp Thr Tyr Ala Leu Asn Gly 
465                 470                 475                 480 


Arg Leu Cys Lys Leu Gly Thr Ala Tyr Cys Tyr Asn Gly Gln Cys Gln 
                485                 490                 495     


Thr Thr Asp Asn Gln Cys Ala Lys Ile Phe Gly Lys Gly Ala Gln Gly 
            500                 505                 510         


Ala Pro Phe Ala Cys Phe Lys Glu Val Asn Ser Leu His Glu Arg Ser 
        515                 520                 525             


Glu Asn Cys Gly Phe Lys Asn Ser Gln Pro Leu Pro Cys Glu Arg Lys 
    530                 535                 540                 


Asp Val Leu Cys Gly Lys Leu Ala Cys Val Gln Pro His Lys Asn Ala 
545                 550                 555                 560 


Asn Lys Ser Asp Ala Gln Ser Thr Val Tyr Ser Tyr Ile Gln Asp His 
                565                 570                 575     


Val Cys Val Ser Ile Ala Thr Gly Ser Ser Met Arg Ser Asp Gly Thr 
            580                 585                 590         


Asp Asn Ala Tyr Val Ala Asp Gly Thr Met Cys Gly Pro Glu Met Tyr 
        595                 600                 605             


Cys Val Asn Lys Thr Cys Arg Lys Val His Leu Met Gly Tyr Asn Cys 
    610                 615                 620                 


Asn Ala Thr Thr Lys Cys Lys Gly Lys Gly Ile Cys Asn Asn Phe Gly 
625                 630                 635                 640 


Asn Cys Gln Cys Phe Pro Gly His Arg Pro Pro Asp Cys Lys Phe Gln 
                645                 650                 655     


Phe Gly Ser Pro Gly Gly Ser Ile Asp Asp Gly Asn Phe Gln Lys Ser 
            660                 665                 670         


Gly Asp Phe Tyr Thr Glu Lys Gly Tyr Asn Thr His Trp Asn Asn Trp 
        675                 680                 685             


Phe Ile Leu Ser Phe Cys Ile Phe Leu Pro Phe Phe Ile Val Phe Thr 
    690                 695                 700                 


Thr Val Ile Phe Lys Arg Asn Glu Ile Ser Lys Ser Cys Asn Arg Glu 
705                 710                 715                 720 


Asn Ala Glu Tyr Asn Arg Asn Ser Ser Val Val Ser Glu Ser Asp Asp 
                725                 730                 735     


Val Gly His 
            


<210>  3894
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  3894

Met Gly Arg Leu Thr Glu Ala Ala Ala Ala Gly Ser Gly Ser Arg Ala 
1               5                   10                  15      


Ala Gly Trp Ala Gly Ser Pro Pro Thr Leu Leu Pro Leu Ser Pro Thr 
            20                  25                  30          


Ser Pro Arg Cys Ala Ala Thr Met Ala Ser Ser Asp Glu Asp Gly Thr 
        35                  40                  45              


Asn Gly Gly Ala Ser Glu Ala Gly Glu Asp Arg Glu Ala Pro Gly Glu 
    50                  55                  60                  


Arg Arg Arg Leu Gly Val Leu Ala Thr Ala Trp Leu Thr Phe Tyr Asp 
65                  70                  75                  80  


Ile Ala Met Thr Ala Gly Trp Leu Val Leu Ala Ile Ala Met Val Arg 
                85                  90                  95      


Phe Tyr Met Glu Lys Gly Thr His Arg Gly Leu Tyr Lys Ser Ile Gln 
            100                 105                 110         


Lys Thr Leu Lys Phe Phe Gln Thr Phe Ala Leu Leu Glu Ile Val His 
        115                 120                 125             


Cys Leu Ile Gly Ile Val Pro Thr Ser Val Ile Val Thr Gly Val Gln 
    130                 135                 140                 


Val Ser Ser Arg Ile Phe Met Val Trp Leu Ile Thr His Ser Ile Lys 
145                 150                 155                 160 


Pro Ile Gln Asn Glu Glu Ser Val Val Leu Phe Leu Val Ala Trp Thr 
                165                 170                 175     


Val Thr Glu Ile Thr Arg Tyr Ser Phe Tyr Thr Phe Ser Leu Leu Asp 
            180                 185                 190         


His Leu Pro Tyr Phe Ile Lys Trp Ala Arg Tyr Asn Phe Phe Ile Ile 
        195                 200                 205             


Leu Tyr Pro Val Gly Val Ala Gly Glu Leu Leu Thr Ile Tyr Ala Ala 
    210                 215                 220                 


Leu Pro His Val Lys Lys Thr Gly Met Phe Ser Ile Arg Leu Pro Asn 
225                 230                 235                 240 


Lys Tyr Asn Val Ser Phe Asp Tyr Tyr Tyr Phe Leu Leu Ile Thr Met 
                245                 250                 255     


Ala Ser Tyr Ile Pro Leu Phe Pro Gln Leu Tyr Phe His Met Leu Arg 
            260                 265                 270         


Gln Arg Arg Lys Val Leu His Gly Glu Val Ile Val Glu Lys Asp Asp 
        275                 280                 285             


<210>  3895
<211>  3014
<212>  PRT
<213>  Homo sapiens

<400>  3895

Met Ala Pro Pro Pro Pro Pro Val Leu Pro Val Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Ala Ala Ala Leu Pro Ala Met Gly Leu Arg Ala Ala Ala Trp Glu 
            20                  25                  30          


Pro Arg Val Pro Gly Gly Thr Arg Ala Phe Ala Leu Arg Pro Gly Cys 
        35                  40                  45              


Thr Tyr Ala Val Gly Ala Ala Cys Thr Pro Arg Ala Pro Arg Glu Leu 
    50                  55                  60                  


Leu Asp Val Gly Arg Asp Gly Arg Leu Ala Gly Arg Arg Arg Val Ser 
65                  70                  75                  80  


Gly Ala Gly Arg Pro Leu Pro Leu Gln Val Arg Leu Val Ala Arg Ser 
                85                  90                  95      


Ala Pro Thr Ala Leu Ser Arg Arg Leu Arg Ala Arg Thr His Leu Pro 
            100                 105                 110         


Gly Cys Gly Ala Arg Ala Arg Leu Cys Gly Thr Gly Ala Arg Leu Cys 
        115                 120                 125             


Gly Ala Leu Cys Phe Pro Val Pro Gly Gly Cys Ala Ala Ala Gln His 
    130                 135                 140                 


Ser Ala Leu Ala Ala Pro Thr Thr Leu Pro Ala Cys Arg Cys Pro Pro 
145                 150                 155                 160 


Arg Pro Arg Pro Arg Cys Pro Gly Arg Pro Ile Cys Leu Pro Pro Gly 
                165                 170                 175     


Gly Ser Val Arg Leu Arg Leu Leu Cys Ala Leu Arg Arg Ala Ala Gly 
            180                 185                 190         


Ala Val Arg Val Gly Leu Ala Leu Glu Ala Ala Thr Ala Gly Thr Pro 
        195                 200                 205             


Ser Ala Ser Pro Ser Pro Ser Pro Pro Leu Pro Pro Asn Leu Pro Glu 
    210                 215                 220                 


Ala Arg Ala Gly Pro Ala Arg Arg Ala Arg Arg Gly Thr Ser Gly Arg 
225                 230                 235                 240 


Gly Ser Leu Lys Phe Pro Met Pro Asn Tyr Gln Val Ala Leu Phe Glu 
                245                 250                 255     


Asn Glu Pro Ala Gly Thr Leu Ile Leu Gln Leu His Ala His Tyr Thr 
            260                 265                 270         


Ile Glu Gly Glu Glu Glu Arg Val Ser Tyr Tyr Met Glu Gly Leu Phe 
        275                 280                 285             


Asp Glu Arg Ser Arg Gly Tyr Phe Arg Ile Asp Ser Ala Thr Gly Ala 
    290                 295                 300                 


Val Ser Thr Asp Ser Val Leu Asp Arg Glu Thr Lys Glu Thr His Val 
305                 310                 315                 320 


Leu Arg Val Lys Ala Val Asp Tyr Ser Thr Pro Pro Arg Ser Ala Thr 
                325                 330                 335     


Thr Tyr Ile Thr Val Leu Val Lys Asp Thr Asn Asp His Ser Pro Val 
            340                 345                 350         


Phe Glu Gln Ser Glu Tyr Arg Glu Arg Val Arg Glu Asn Leu Glu Val 
        355                 360                 365             


Gly Tyr Glu Val Leu Thr Ile Arg Ala Ser Asp Arg Asp Ser Pro Ile 
    370                 375                 380                 


Asn Ala Asn Leu Arg Tyr Arg Val Leu Gly Gly Ala Trp Asp Val Phe 
385                 390                 395                 400 


Gln Leu Asn Glu Ser Ser Gly Val Val Ser Thr Arg Ala Val Leu Asp 
                405                 410                 415     


Arg Glu Glu Ala Ala Glu Tyr Gln Leu Leu Val Glu Ala Asn Asp Gln 
            420                 425                 430         


Gly Arg Asn Pro Gly Pro Leu Ser Ala Thr Ala Thr Val Tyr Ile Glu 
        435                 440                 445             


Val Glu Asp Glu Asn Asp Asn Tyr Pro Gln Phe Ser Glu Gln Asn Tyr 
    450                 455                 460                 


Val Val Gln Val Pro Glu Asp Val Gly Leu Asn Thr Ala Val Leu Arg 
465                 470                 475                 480 


Val Gln Ala Thr Asp Arg Asp Gln Gly Gln Asn Ala Ala Ile His Tyr 
                485                 490                 495     


Ser Ile Leu Ser Gly Asn Val Ala Gly Gln Phe Tyr Leu His Ser Leu 
            500                 505                 510         


Ser Gly Ile Leu Asp Val Ile Asn Pro Leu Asp Phe Glu Asp Val Gln 
        515                 520                 525             


Lys Tyr Ser Leu Ser Ile Lys Ala Gln Asp Gly Gly Arg Pro Pro Leu 
    530                 535                 540                 


Ile Asn Ser Ser Gly Val Val Ser Val Gln Val Leu Asp Val Asn Asp 
545                 550                 555                 560 


Asn Glu Pro Ile Phe Val Ser Ser Pro Phe Gln Ala Thr Val Leu Glu 
                565                 570                 575     


Asn Val Pro Leu Gly Tyr Pro Val Val His Ile Gln Ala Val Asp Ala 
            580                 585                 590         


Asp Ser Gly Glu Asn Ala Arg Leu His Tyr Arg Leu Val Asp Thr Ala 
        595                 600                 605             


Ser Thr Phe Leu Gly Gly Gly Ser Ala Gly Pro Lys Asn Pro Ala Pro 
    610                 615                 620                 


Thr Pro Asp Phe Pro Phe Gln Ile His Asn Ser Ser Gly Trp Ile Thr 
625                 630                 635                 640 


Val Cys Ala Glu Leu Asp Arg Glu Glu Val Glu His Tyr Ser Phe Gly 
                645                 650                 655     


Val Glu Ala Val Asp His Gly Ser Pro Pro Met Ser Ser Ser Thr Ser 
            660                 665                 670         


Val Ser Ile Thr Val Leu Asp Val Asn Asp Asn Asp Pro Val Phe Thr 
        675                 680                 685             


Gln Pro Thr Tyr Glu Leu Arg Leu Asn Glu Asp Ala Ala Val Gly Ser 
    690                 695                 700                 


Ser Val Leu Thr Leu Gln Ala Arg Asp Arg Asp Ala Asn Ser Val Ile 
705                 710                 715                 720 


Thr Tyr Gln Leu Thr Gly Gly Asn Thr Arg Asn Arg Phe Ala Leu Ser 
                725                 730                 735     


Ser Gln Arg Gly Gly Gly Leu Ile Thr Leu Ala Leu Pro Leu Asp Tyr 
            740                 745                 750         


Lys Gln Glu Gln Gln Tyr Val Leu Ala Val Thr Ala Ser Asp Gly Thr 
        755                 760                 765             


Arg Ser His Thr Ala His Val Leu Ile Asn Val Thr Asp Ala Asn Thr 
    770                 775                 780                 


His Arg Pro Val Phe Gln Ser Ser His Tyr Thr Val Ser Val Ser Glu 
785                 790                 795                 800 


Asp Arg Pro Val Gly Thr Ser Ile Ala Thr Leu Ser Ala Asn Asp Glu 
                805                 810                 815     


Asp Thr Gly Glu Asn Ala Arg Ile Thr Tyr Val Ile Gln Asp Pro Val 
            820                 825                 830         


Pro Gln Phe Arg Ile Asp Pro Asp Ser Gly Thr Met Tyr Thr Met Met 
        835                 840                 845             


Glu Leu Asp Tyr Glu Asn Gln Val Ala Tyr Thr Leu Thr Ile Met Ala 
    850                 855                 860                 


Gln Asp Asn Gly Ile Pro Gln Lys Ser Asp Thr Thr Thr Leu Glu Ile 
865                 870                 875                 880 


Leu Ile Leu Asp Ala Asn Asp Asn Ala Pro Gln Phe Leu Trp Asp Phe 
                885                 890                 895     


Tyr Gln Gly Ser Ile Phe Glu Asp Ala Pro Pro Ser Thr Ser Ile Leu 
            900                 905                 910         


Gln Val Ser Ala Thr Asp Arg Asp Ser Gly Pro Asn Gly Arg Leu Leu 
        915                 920                 925             


Tyr Thr Phe Gln Gly Gly Asp Asp Gly Asp Gly Asp Phe Tyr Ile Glu 
    930                 935                 940                 


Pro Thr Ser Gly Val Ile Arg Thr Gln Arg Arg Leu Asp Arg Glu Asn 
945                 950                 955                 960 


Val Ala Val Tyr Asn Leu Trp Ala Leu Ala Val Asp Arg Gly Ser Pro 
                965                 970                 975     


Thr Pro Leu Ser Ala Ser Val Glu Ile Gln Val Thr Ile Leu Asp Ile 
            980                 985                 990         


Asn Asp Asn Ala Pro Met Phe Glu  Lys Asp Glu Leu Glu  Leu Phe Val 
        995                 1000                 1005             


Glu Glu  Asn Asn Pro Val Gly  Ser Val Val Ala Lys  Ile Arg Ala 
    1010                 1015                 1020             


Asn Asp  Pro Asp Glu Gly Pro  Asn Ala Gln Ile Met  Tyr Gln Ile 
    1025                 1030                 1035             


Val Glu  Gly Asp Met Arg His  Phe Phe Gln Leu Asp  Leu Leu Asn 
    1040                 1045                 1050             


Gly Asp  Leu Arg Ala Met Val  Glu Leu Asp Phe Glu  Val Arg Arg 
    1055                 1060                 1065             


Glu Tyr  Val Leu Val Val Gln  Ala Thr Ser Ala Pro  Leu Val Ser 
    1070                 1075                 1080             


Arg Ala  Thr Val His Ile Leu  Leu Val Asp Gln Asn  Asp Asn Pro 
    1085                 1090                 1095             


Pro Val  Leu Pro Asp Phe Gln  Ile Leu Phe Asn Asn  Tyr Val Thr 
    1100                 1105                 1110             


Asn Lys  Ser Asn Ser Phe Pro  Thr Gly Val Ile Gly  Cys Ile Pro 
    1115                 1120                 1125             


Ala His  Asp Pro Asp Val Ser  Asp Ser Leu Asn Tyr  Thr Phe Val 
    1130                 1135                 1140             


Gln Gly  Asn Glu Leu Arg Leu  Leu Leu Leu Asp Pro  Ala Thr Gly 
    1145                 1150                 1155             


Glu Leu  Gln Leu Ser Arg Asp  Leu Asp Asn Asn Arg  Pro Leu Glu 
    1160                 1165                 1170             


Ala Leu  Met Glu Val Ser Val  Ser Asp Gly Ile His  Ser Val Thr 
    1175                 1180                 1185             


Ala Phe  Cys Thr Leu Arg Val  Thr Ile Ile Thr Asp  Asp Met Leu 
    1190                 1195                 1200             


Thr Asn  Ser Ile Thr Val Arg  Leu Glu Asn Met Ser  Gln Glu Lys 
    1205                 1210                 1215             


Phe Leu  Ser Pro Leu Leu Ala  Leu Phe Val Glu Gly  Val Ala Ala 
    1220                 1225                 1230             


Val Leu  Ser Thr Thr Lys Asp  Asp Val Phe Val Phe  Asn Val Gln 
    1235                 1240                 1245             


Asn Asp  Thr Asp Val Ser Ser  Asn Ile Leu Asn Val  Thr Phe Ser 
    1250                 1255                 1260             


Ala Leu  Leu Pro Gly Gly Val  Arg Gly Gln Phe Phe  Pro Ser Glu 
    1265                 1270                 1275             


Asp Leu  Gln Glu Gln Ile Tyr  Leu Asn Arg Thr Leu  Leu Thr Thr 
    1280                 1285                 1290             


Ile Ser  Thr Gln Arg Val Leu  Pro Phe Asp Asp Asn  Ile Cys Leu 
    1295                 1300                 1305             


Arg Glu  Pro Cys Glu Asn Tyr  Met Lys Cys Val Ser  Val Leu Arg 
    1310                 1315                 1320             


Phe Asp  Ser Ser Ala Pro Phe  Leu Ser Ser Thr Thr  Val Leu Phe 
    1325                 1330                 1335             


Arg Pro  Ile His Pro Ile Asn  Gly Leu Arg Cys Arg  Cys Pro Pro 
    1340                 1345                 1350             


Gly Phe  Thr Gly Asp Tyr Cys  Glu Thr Glu Ile Asp  Leu Cys Tyr 
    1355                 1360                 1365             


Ser Asp  Pro Cys Gly Ala Asn  Gly Arg Cys Arg Ser  Arg Glu Gly 
    1370                 1375                 1380             


Gly Tyr  Thr Cys Glu Cys Phe  Glu Asp Phe Thr Gly  Glu His Cys 
    1385                 1390                 1395             


Glu Val  Asp Ala Arg Ser Gly  Arg Cys Ala Asn Gly  Val Cys Lys 
    1400                 1405                 1410             


Asn Gly  Gly Thr Cys Val Asn  Leu Leu Ile Gly Gly  Phe His Cys 
    1415                 1420                 1425             


Val Cys  Pro Pro Gly Glu Tyr  Glu Arg Pro Tyr Cys  Glu Val Thr 
    1430                 1435                 1440             


Thr Arg  Ser Phe Pro Pro Gln  Ser Phe Val Thr Phe  Arg Gly Leu 
    1445                 1450                 1455             


Arg Gln  Arg Phe His Phe Thr  Ile Ser Leu Thr Phe  Ala Thr Gln 
    1460                 1465                 1470             


Glu Arg  Asn Gly Leu Leu Leu  Tyr Asn Gly Arg Phe  Asn Glu Lys 
    1475                 1480                 1485             


His Asp  Phe Ile Ala Leu Glu  Ile Val Asp Glu Gln  Val Gln Leu 
    1490                 1495                 1500             


Thr Phe  Ser Ala Gly Glu Thr  Thr Thr Thr Val Ala  Pro Lys Val 
    1505                 1510                 1515             


Pro Ser  Gly Val Ser Asp Gly  Arg Trp His Ser Val  Gln Val Gln 
    1520                 1525                 1530             


Tyr Tyr  Asn Lys Pro Asn Ile  Gly His Leu Gly Leu  Pro His Gly 
    1535                 1540                 1545             


Pro Ser  Gly Glu Lys Met Ala  Val Val Thr Val Asp  Asp Cys Asp 
    1550                 1555                 1560             


Thr Thr  Met Ala Val Arg Phe  Gly Lys Asp Ile Gly  Asn Tyr Ser 
    1565                 1570                 1575             


Cys Ala  Ala Gln Gly Thr Gln  Thr Gly Ser Lys Lys  Ser Leu Asp 
    1580                 1585                 1590             


Leu Thr  Gly Pro Leu Leu Leu  Gly Gly Val Pro Asn  Leu Pro Glu 
    1595                 1600                 1605             


Asp Phe  Pro Val His Asn Arg  Gln Phe Val Gly Cys  Met Arg Asn 
    1610                 1615                 1620             


Leu Ser  Val Asp Gly Lys Asn  Val Asp Met Ala Gly  Phe Ile Ala 
    1625                 1630                 1635             


Asn Asn  Gly Thr Arg Glu Gly  Cys Ala Ala Arg Arg  Asn Phe Cys 
    1640                 1645                 1650             


Asp Gly  Arg Arg Cys Gln Asn  Gly Gly Thr Cys Val  Asn Arg Trp 
    1655                 1660                 1665             


Asn Met  Tyr Leu Cys Glu Cys  Pro Leu Arg Phe Gly  Gly Lys Asn 
    1670                 1675                 1680             


Cys Glu  Gln Ala Met Pro His  Pro Gln Leu Phe Ser  Gly Glu Ser 
    1685                 1690                 1695             


Val Val  Ser Trp Ser Asp Leu  Asn Ile Ile Ile Ser  Val Pro Trp 
    1700                 1705                 1710             


Tyr Leu  Gly Leu Met Phe Arg  Thr Arg Lys Glu Asp  Ser Val Leu 
    1715                 1720                 1725             


Met Glu  Ala Thr Ser Gly Gly  Pro Thr Ser Phe Arg  Leu Gln Ile 
    1730                 1735                 1740             


Leu Asn  Asn Tyr Leu Gln Phe  Glu Val Ser His Gly  Pro Ser Asp 
    1745                 1750                 1755             


Val Glu  Ser Val Met Leu Ser  Gly Leu Arg Val Thr  Asp Gly Glu 
    1760                 1765                 1770             


Trp His  His Leu Leu Ile Glu  Leu Lys Asn Val Lys  Glu Asp Ser 
    1775                 1780                 1785             


Glu Met  Lys His Leu Val Thr  Met Thr Leu Asp Tyr  Gly Met Asp 
    1790                 1795                 1800             


Gln Asn  Lys Ala Asp Ile Gly  Gly Met Leu Pro Gly  Leu Thr Val 
    1805                 1810                 1815             


Arg Ser  Val Val Val Gly Gly  Ala Ser Glu Asp Lys  Val Ser Val 
    1820                 1825                 1830             


Arg Arg  Gly Phe Arg Gly Cys  Met Gln Gly Val Arg  Met Gly Gly 
    1835                 1840                 1845             


Thr Pro  Thr Asn Val Ala Thr  Leu Asn Met Asn Asn  Ala Leu Lys 
    1850                 1855                 1860             


Val Arg  Val Lys Asp Gly Cys  Asp Val Asp Asp Pro  Cys Thr Ser 
    1865                 1870                 1875             


Ser Pro  Cys Pro Pro Asn Ser  Arg Cys His Asp Ala  Trp Glu Asp 
    1880                 1885                 1890             


Tyr Ser  Cys Val Cys Asp Lys  Gly Tyr Leu Gly Ile  Asn Cys Val 
    1895                 1900                 1905             


Asp Ala  Cys His Leu Asn Pro  Cys Glu Asn Met Gly  Ala Cys Val 
    1910                 1915                 1920             


Arg Ser  Pro Gly Ser Pro Gln  Gly Tyr Val Cys Glu  Cys Gly Pro 
    1925                 1930                 1935             


Ser His  Tyr Gly Pro Tyr Cys  Glu Asn Lys Leu Asp  Leu Pro Cys 
    1940                 1945                 1950             


Pro Arg  Gly Trp Trp Gly Asn  Pro Val Cys Gly Pro  Cys His Cys 
    1955                 1960                 1965             


Ala Val  Ser Lys Gly Phe Asp  Pro Asp Cys Asn Lys  Thr Asn Gly 
    1970                 1975                 1980             


Gln Cys  Gln Cys Lys Glu Asn  Tyr Tyr Lys Leu Leu  Ala Gln Asp 
    1985                 1990                 1995             


Thr Cys  Leu Pro Cys Asp Cys  Phe Pro His Gly Ser  His Ser Arg 
    2000                 2005                 2010             


Thr Cys  Asp Met Ala Thr Gly  Gln Cys Ala Cys Lys  Pro Gly Val 
    2015                 2020                 2025             


Ile Gly  Arg Gln Cys Asn Arg  Cys Asp Asn Pro Phe  Ala Glu Val 
    2030                 2035                 2040             


Thr Thr  Leu Gly Cys Glu Val  Ile Tyr Asn Gly Cys  Pro Lys Ala 
    2045                 2050                 2055             


Phe Glu  Ala Gly Ile Trp Trp  Pro Gln Thr Lys Phe  Gly Gln Pro 
    2060                 2065                 2070             


Ala Ala  Val Pro Cys Pro Lys  Gly Ser Val Gly Asn  Ala Val Arg 
    2075                 2080                 2085             


His Cys  Ser Gly Glu Lys Gly  Trp Leu Pro Pro Glu  Leu Phe Asn 
    2090                 2095                 2100             


Cys Thr  Thr Ile Ser Phe Val  Asp Leu Arg Ala Met  Asn Glu Lys 
    2105                 2110                 2115             


Leu Ser  Arg Asn Glu Thr Gln  Val Asp Gly Ala Arg  Ala Leu Gln 
    2120                 2125                 2130             


Leu Val  Arg Ala Leu Arg Ser  Ala Thr Gln His Thr  Gly Thr Leu 
    2135                 2140                 2145             


Phe Gly  Asn Asp Val Arg Thr  Ala Tyr Gln Leu Leu  Gly His Val 
    2150                 2155                 2160             


Leu Gln  His Glu Ser Trp Gln  Gln Gly Phe Asp Leu  Ala Ala Thr 
    2165                 2170                 2175             


Gln Asp  Ala Asp Phe His Glu  Asp Val Ile His Ser  Gly Ser Ala 
    2180                 2185                 2190             


Leu Leu  Ala Pro Ala Thr Arg  Ala Ala Trp Glu Gln  Ile Gln Arg 
    2195                 2200                 2205             


Ser Glu  Gly Gly Thr Ala Gln  Leu Leu Arg Arg Leu  Glu Gly Tyr 
    2210                 2215                 2220             


Phe Ser  Asn Val Ala Arg Asn  Val Arg Arg Thr Tyr  Leu Arg Pro 
    2225                 2230                 2235             


Phe Val  Ile Val Thr Ala Asn  Met Ile Leu Ala Val  Asp Ile Phe 
    2240                 2245                 2250             


Asp Lys  Phe Asn Phe Thr Gly  Ala Arg Val Pro Arg  Phe Asp Thr 
    2255                 2260                 2265             


Ile His  Glu Glu Phe Pro Arg  Glu Leu Glu Ser Ser  Val Ser Phe 
    2270                 2275                 2280             


Pro Ala  Asp Phe Phe Arg Pro  Pro Glu Glu Lys Glu  Gly Pro Leu 
    2285                 2290                 2295             


Leu Arg  Pro Ala Gly Arg Arg  Thr Thr Pro Gln Thr  Thr Arg Pro 
    2300                 2305                 2310             


Gly Pro  Gly Thr Glu Arg Glu  Ala Pro Ile Ser Arg  Arg Arg Arg 
    2315                 2320                 2325             


His Pro  Asp Asp Ala Gly Gln  Phe Ala Val Ala Leu  Val Ile Ile 
    2330                 2335                 2340             


Tyr Arg  Thr Leu Gly Gln Leu  Leu Pro Glu Arg Tyr  Asp Pro Asp 
    2345                 2350                 2355             


Arg Arg  Ser Leu Arg Leu Pro  His Arg Pro Ile Ile  Asn Thr Pro 
    2360                 2365                 2370             


Met Val  Ser Thr Leu Val Tyr  Ser Glu Gly Ala Pro  Leu Pro Arg 
    2375                 2380                 2385             


Pro Leu  Glu Arg Pro Val Leu  Val Glu Phe Ala Leu  Leu Glu Val 
    2390                 2395                 2400             


Glu Glu  Arg Thr Lys Pro Val  Cys Val Phe Trp Asn  His Ser Leu 
    2405                 2410                 2415             


Ala Val  Gly Gly Thr Gly Gly  Trp Ser Ala Arg Gly  Cys Glu Leu 
    2420                 2425                 2430             


Leu Ser  Arg Asn Arg Thr His  Val Ala Cys Gln Cys  Ser His Thr 
    2435                 2440                 2445             


Ala Ser  Phe Ala Val Leu Met  Asp Ile Ser Arg Arg  Glu Asn Gly 
    2450                 2455                 2460             


Glu Val  Leu Pro Leu Lys Ile  Val Thr Tyr Ala Ala  Val Ser Leu 
    2465                 2470                 2475             


Ser Leu  Ala Ala Leu Leu Val  Ala Phe Val Leu Leu  Ser Leu Val 
    2480                 2485                 2490             


Arg Met  Leu Arg Ser Asn Leu  His Ser Ile His Lys  His Leu Ala 
    2495                 2500                 2505             


Val Ala  Leu Phe Leu Ser Gln  Leu Val Phe Val Ile  Gly Ile Asn 
    2510                 2515                 2520             


Gln Thr  Glu Asn Pro Phe Leu  Cys Thr Val Val Ala  Ile Leu Leu 
    2525                 2530                 2535             


His Tyr  Ile Tyr Met Ser Thr  Phe Ala Trp Thr Leu  Val Glu Ser 
    2540                 2545                 2550             


Leu His  Val Tyr Arg Met Leu  Thr Glu Val Arg Asn  Ile Asp Thr 
    2555                 2560                 2565             


Gly Pro  Met Arg Phe Tyr Tyr  Val Val Gly Trp Gly  Ile Pro Ala 
    2570                 2575                 2580             


Ile Val  Thr Gly Leu Ala Val  Gly Leu Asp Pro Gln  Gly Tyr Gly 
    2585                 2590                 2595             


Asn Pro  Asp Phe Cys Trp Leu  Ser Leu Gln Asp Thr  Leu Ile Trp 
    2600                 2605                 2610             


Ser Phe  Ala Gly Pro Ile Gly  Ala Val Ile Ile Ile  Asn Thr Val 
    2615                 2620                 2625             


Thr Ser  Val Leu Ser Ala Lys  Val Ser Cys Gln Arg  Lys His His 
    2630                 2635                 2640             


Tyr Tyr  Gly Lys Lys Gly Ile  Val Ser Leu Leu Arg  Thr Ala Phe 
    2645                 2650                 2655             


Leu Leu  Leu Leu Leu Ile Ser  Ala Thr Trp Leu Leu  Gly Leu Leu 
    2660                 2665                 2670             


Ala Val  Asn Arg Asp Ala Leu  Ser Phe His Tyr Leu  Phe Ala Ile 
    2675                 2680                 2685             


Phe Ser  Gly Leu Gln Gly Pro  Phe Val Leu Leu Phe  His Cys Val 
    2690                 2695                 2700             


Leu Asn  Gln Glu Val Arg Lys  His Leu Lys Gly Val  Leu Gly Gly 
    2705                 2710                 2715             


Arg Lys  Leu His Leu Glu Asp  Ser Ala Thr Thr Arg  Ala Thr Leu 
    2720                 2725                 2730             


Leu Thr  Arg Ser Leu Asn Cys  Asn Thr Thr Phe Gly  Asp Gly Pro 
    2735                 2740                 2745             


Asp Met  Leu Arg Thr Asp Leu  Gly Glu Ser Thr Ala  Ser Leu Asp 
    2750                 2755                 2760             


Ser Ile  Val Arg Asp Glu Gly  Ile Gln Lys Leu Gly  Val Ser Ser 
    2765                 2770                 2775             


Gly Leu  Val Arg Gly Ser His  Gly Glu Pro Asp Ala  Ser Leu Met 
    2780                 2785                 2790             


Pro Arg  Ser Cys Lys Asp Pro  Pro Gly His Asp Ser  Asp Ser Asp 
    2795                 2800                 2805             


Ser Glu  Leu Ser Leu Asp Glu  Gln Ser Ser Ser Tyr  Ala Ser Ser 
    2810                 2815                 2820             


His Ser  Ser Asp Ser Glu Asp  Asp Gly Val Gly Ala  Glu Glu Lys 
    2825                 2830                 2835             


Trp Asp  Pro Ala Arg Gly Ala  Val His Ser Thr Pro  Lys Gly Asp 
    2840                 2845                 2850             


Ala Val  Ala Asn His Val Pro  Ala Gly Trp Pro Asp  Gln Ser Leu 
    2855                 2860                 2865             


Ala Glu  Ser Asp Ser Glu Asp  Pro Ser Gly Lys Pro  Arg Leu Lys 
    2870                 2875                 2880             


Val Glu  Thr Lys Val Ser Val  Glu Leu His Arg Glu  Glu Gln Gly 
    2885                 2890                 2895             


Ser His  Arg Gly Glu Tyr Pro  Pro Asp Gln Glu Ser  Gly Gly Ala 
    2900                 2905                 2910             


Ala Arg  Leu Ala Ser Ser Gln  Pro Pro Glu Gln Arg  Lys Gly Ile 
    2915                 2920                 2925             


Leu Lys  Asn Lys Val Thr Tyr  Pro Pro Pro Leu Thr  Leu Thr Glu 
    2930                 2935                 2940             


Gln Thr  Leu Lys Gly Arg Leu  Arg Glu Lys Leu Ala  Asp Cys Glu 
    2945                 2950                 2955             


Gln Ser  Pro Thr Ser Ser Arg  Thr Ser Ser Leu Gly  Ser Gly Gly 
    2960                 2965                 2970             


Pro Asp  Cys Ala Ile Thr Val  Lys Ser Pro Gly Arg  Glu Pro Gly 
    2975                 2980                 2985             


Arg Asp  His Leu Asn Gly Val  Ala Met Asn Val Arg  Thr Gly Ser 
    2990                 2995                 3000             


Ala Gln  Ala Asp Gly Ser Asp  Ser Glu Lys Pro 
    3005                 3010                 


<210>  3896
<211>  2725
<212>  PRT
<213>  Homo sapiens

<400>  3896

Met Glu Gln Thr Asp Cys Lys Pro Tyr Gln Pro Leu Pro Lys Val Lys 
1               5                   10                  15      


His Glu Met Asp Leu Ala Tyr Thr Ser Ser Ser Asp Glu Ser Glu Asp 
            20                  25                  30          


Gly Arg Lys Pro Arg Gln Ser Tyr Asn Ser Arg Glu Thr Leu His Glu 
        35                  40                  45              


Tyr Asn Gln Glu Leu Arg Met Asn Tyr Asn Ser Gln Ser Arg Lys Arg 
    50                  55                  60                  


Lys Glu Val Glu Lys Ser Thr Gln Glu Met Glu Phe Cys Glu Thr Ser 
65                  70                  75                  80  


His Thr Leu Cys Ser Gly Tyr Gln Thr Asp Met His Ser Val Ser Arg 
                85                  90                  95      


His Gly Tyr Gln Leu Glu Met Gly Ser Asp Val Asp Thr Glu Thr Glu 
            100                 105                 110         


Gly Ala Ala Ser Pro Asp His Ala Leu Arg Met Trp Ile Arg Gly Met 
        115                 120                 125             


Lys Ser Glu His Ser Ser Cys Leu Ser Ser Arg Ala Asn Ser Ala Leu 
    130                 135                 140                 


Ser Leu Thr Asp Thr Asp His Glu Arg Lys Ser Asp Gly Glu Asn Gly 
145                 150                 155                 160 


Phe Lys Phe Ser Pro Val Cys Cys Asp Met Glu Ala Gln Ala Gly Ser 
                165                 170                 175     


Thr Gln Asp Val Gln Ser Ser Pro His Asn Gln Phe Thr Phe Arg Pro 
            180                 185                 190         


Leu Pro Pro Pro Pro Pro Pro Pro His Ala Cys Thr Cys Ala Arg Lys 
        195                 200                 205             


Pro Pro Pro Ala Ala Asp Ser Leu Gln Arg Arg Ser Met Thr Thr Arg 
    210                 215                 220                 


Ser Gln Pro Ser Pro Ala Ala Pro Ala Pro Pro Thr Ser Thr Gln Asp 
225                 230                 235                 240 


Ser Val His Leu His Asn Ser Trp Val Leu Asn Ser Asn Ile Pro Leu 
                245                 250                 255     


Glu Thr Arg His Phe Leu Phe Lys His Gly Ser Gly Ser Ser Ala Ile 
            260                 265                 270         


Phe Ser Ala Ala Ser Gln Asn Tyr Pro Leu Thr Ser Asn Thr Val Tyr 
        275                 280                 285             


Ser Pro Pro Pro Arg Pro Leu Pro Arg Ser Thr Phe Ser Arg Pro Ala 
    290                 295                 300                 


Phe Thr Phe Asn Lys Pro Tyr Arg Cys Cys Asn Trp Lys Cys Thr Ala 
305                 310                 315                 320 


Leu Ser Ala Thr Ala Ile Thr Val Thr Leu Ala Leu Leu Leu Ala Tyr 
                325                 330                 335     


Val Ile Ala Val His Leu Phe Gly Leu Thr Trp Gln Leu Gln Pro Val 
            340                 345                 350         


Glu Gly Glu Leu Tyr Ala Asn Gly Val Ser Lys Gly Asn Arg Gly Thr 
        355                 360                 365             


Glu Ser Met Asp Thr Thr Tyr Ser Pro Ile Gly Gly Lys Val Ser Asp 
    370                 375                 380                 


Lys Ser Glu Lys Lys Val Phe Gln Lys Gly Arg Ala Ile Asp Thr Gly 
385                 390                 395                 400 


Glu Val Asp Ile Gly Ala Gln Val Met Gln Thr Ile Pro Pro Gly Leu 
                405                 410                 415     


Phe Trp Arg Phe Gln Ile Thr Ile His His Pro Ile Tyr Leu Lys Phe 
            420                 425                 430         


Asn Ile Ser Leu Ala Lys Asp Ser Leu Leu Gly Ile Tyr Gly Arg Arg 
        435                 440                 445             


Asn Ile Pro Pro Thr His Thr Gln Phe Asp Phe Val Lys Leu Met Asp 
    450                 455                 460                 


Gly Lys Gln Leu Val Lys Gln Asp Ser Lys Gly Ser Asp Asp Thr Gln 
465                 470                 475                 480 


His Ser Pro Arg Asn Leu Ile Leu Thr Ser Leu Gln Glu Thr Gly Phe 
                485                 490                 495     


Ile Glu Tyr Met Asp Gln Gly Pro Trp Tyr Leu Ala Phe Tyr Asn Asp 
            500                 505                 510         


Gly Lys Lys Met Glu Gln Val Phe Val Leu Thr Thr Ala Ile Glu Ile 
        515                 520                 525             


Met Asp Asp Cys Ser Thr Asn Cys Asn Gly Asn Gly Glu Cys Ile Ser 
    530                 535                 540                 


Gly His Cys His Cys Phe Pro Gly Phe Leu Gly Pro Asp Cys Ala Arg 
545                 550                 555                 560 


Asp Ser Cys Pro Val Leu Cys Gly Gly Asn Gly Glu Tyr Glu Lys Gly 
                565                 570                 575     


His Cys Val Cys Arg His Gly Trp Lys Gly Pro Glu Cys Asp Val Pro 
            580                 585                 590         


Glu Glu Gln Cys Ile Asp Pro Thr Cys Phe Gly His Gly Thr Cys Ile 
        595                 600                 605             


Met Gly Val Cys Ile Cys Val Pro Gly Tyr Lys Gly Glu Ile Cys Glu 
    610                 615                 620                 


Glu Glu Asp Cys Leu Asp Pro Met Cys Ser Asn His Gly Ile Cys Val 
625                 630                 635                 640 


Lys Gly Glu Cys His Cys Ser Thr Gly Trp Gly Gly Val Asn Cys Glu 
                645                 650                 655     


Thr Pro Leu Pro Val Cys Gln Glu Gln Cys Ser Gly His Gly Thr Phe 
            660                 665                 670         


Leu Leu Asp Ala Gly Val Cys Ser Cys Asp Pro Lys Trp Thr Gly Ser 
        675                 680                 685             


Asp Cys Ser Thr Glu Leu Cys Thr Met Glu Cys Gly Ser His Gly Val 
    690                 695                 700                 


Cys Ser Arg Gly Ile Cys Gln Cys Glu Glu Gly Trp Val Gly Pro Thr 
705                 710                 715                 720 


Cys Glu Glu Arg Ser Cys His Ser His Cys Thr Glu His Gly Gln Cys 
                725                 730                 735     


Lys Asp Gly Lys Cys Glu Cys Ser Pro Gly Trp Glu Gly Asp His Cys 
            740                 745                 750         


Thr Ile Ala His Tyr Leu Asp Ala Val Arg Asp Gly Cys Pro Gly Leu 
        755                 760                 765             


Cys Phe Gly Asn Gly Arg Cys Thr Leu Asp Gln Asn Gly Trp His Cys 
    770                 775                 780                 


Val Cys Gln Val Gly Trp Ser Gly Thr Gly Cys Asn Val Val Met Glu 
785                 790                 795                 800 


Met Leu Cys Gly Asp Asn Leu Asp Asn Asp Gly Asp Gly Leu Thr Asp 
                805                 810                 815     


Cys Val Asp Pro Asp Cys Cys Gln Gln Ser Asn Cys Tyr Ile Ser Pro 
            820                 825                 830         


Leu Cys Gln Gly Ser Pro Asp Pro Leu Asp Leu Ile Gln Gln Ser Gln 
        835                 840                 845             


Thr Leu Phe Ser Gln His Thr Ser Arg Leu Phe Tyr Asp Arg Ile Lys 
    850                 855                 860                 


Phe Leu Ile Gly Lys Asp Ser Thr His Val Ile Pro Pro Glu Val Ser 
865                 870                 875                 880 


Phe Asp Ser Arg Arg Ala Cys Val Ile Arg Gly Gln Val Val Ala Ile 
                885                 890                 895     


Asp Gly Thr Pro Leu Val Gly Val Asn Val Ser Phe Leu His His Ser 
            900                 905                 910         


Asp Tyr Gly Phe Thr Ile Ser Arg Gln Asp Gly Ser Phe Asp Leu Val 
        915                 920                 925             


Ala Ile Gly Gly Ile Ser Val Ile Leu Ile Phe Asp Arg Ser Pro Phe 
    930                 935                 940                 


Leu Pro Glu Lys Arg Thr Leu Trp Leu Pro Trp Asn Gln Phe Ile Val 
945                 950                 955                 960 


Val Glu Lys Val Thr Met Gln Arg Val Val Ser Asp Pro Pro Ser Cys 
                965                 970                 975     


Asp Ile Ser Asn Phe Ile Ser Pro Asn Pro Ile Val Leu Pro Ser Pro 
            980                 985                 990         


Leu Thr Ser Phe Gly Gly Ser Cys  Pro Glu Arg Gly Thr  Ile Val Pro 
        995                 1000                 1005             


Glu Leu  Gln Val Val Gln Glu  Glu Ile Pro Ile Pro  Ser Ser Phe 
    1010                 1015                 1020             


Val Arg  Leu Ser Tyr Leu Ser  Ser Arg Thr Pro Gly  Tyr Lys Thr 
    1025                 1030                 1035             


Leu Leu  Arg Ile Leu Leu Thr  His Ser Thr Ile Pro  Val Gly Met 
    1040                 1045                 1050             


Ile Lys  Val His Leu Thr Val  Ala Val Glu Gly Arg  Leu Thr Gln 
    1055                 1060                 1065             


Lys Trp  Phe Pro Ala Ala Ile  Asn Leu Val Tyr Thr  Phe Ala Trp 
    1070                 1075                 1080             


Asn Lys  Thr Asp Ile Tyr Gly  Gln Lys Val Trp Gly  Leu Ala Glu 
    1085                 1090                 1095             


Ala Leu  Val Ser Val Gly Tyr  Glu Tyr Glu Thr Cys  Pro Asp Phe 
    1100                 1105                 1110             


Ile Leu  Trp Glu Gln Arg Thr  Val Val Leu Gln Gly  Phe Glu Met 
    1115                 1120                 1125             


Asp Ala  Ser Asn Leu Gly Gly  Trp Ser Leu Asn Lys  His His Ile 
    1130                 1135                 1140             


Leu Asn  Pro Gln Ser Gly Ile  Ile His Lys Gly Asn  Gly Glu Asn 
    1145                 1150                 1155             


Met Phe  Ile Ser Gln Gln Pro  Pro Val Ile Ser Thr  Ile Met Gly 
    1160                 1165                 1170             


Asn Gly  His Gln Arg Ser Val  Ala Cys Thr Asn Cys  Asn Gly Pro 
    1175                 1180                 1185             


Ala His  Asn Asn Lys Leu Phe  Ala Pro Val Ala Leu  Ala Ser Gly 
    1190                 1195                 1200             


Pro Asp  Gly Ser Val Tyr Val  Gly Asp Phe Asn Phe  Val Arg Arg 
    1205                 1210                 1215             


Ile Phe  Pro Ser Gly Asn Ser  Val Ser Ile Leu Glu  Leu Ser Thr 
    1220                 1225                 1230             


Ser Pro  Ala His Lys Tyr Tyr  Leu Ala Met Asp Pro  Val Ser Glu 
    1235                 1240                 1245             


Ser Leu  Tyr Leu Ser Asp Thr  Asn Thr Arg Lys Val  Tyr Lys Leu 
    1250                 1255                 1260             


Lys Ser  Leu Val Glu Thr Lys  Asp Leu Ser Lys Asn  Phe Glu Val 
    1265                 1270                 1275             


Val Ala  Gly Thr Gly Asp Gln  Cys Leu Pro Phe Asp  Gln Ser His 
    1280                 1285                 1290             


Cys Gly  Asp Gly Gly Arg Ala  Ser Glu Ala Ser Leu  Asn Ser Pro 
    1295                 1300                 1305             


Arg Gly  Ile Thr Val Asp Arg  His Gly Phe Ile Tyr  Phe Val Asp 
    1310                 1315                 1320             


Gly Thr  Met Ile Arg Lys Ile  Asp Glu Asn Ala Val  Ile Thr Thr 
    1325                 1330                 1335             


Val Ile  Gly Ser Asn Gly Leu  Thr Ser Thr Gln Pro  Leu Ser Cys 
    1340                 1345                 1350             


Asp Ser  Gly Met Asp Ile Thr  Gln Val Arg Leu Glu  Trp Pro Thr 
    1355                 1360                 1365             


Asp Leu  Ala Val Asn Pro Met  Asp Asn Ser Leu Tyr  Val Leu Asp 
    1370                 1375                 1380             


Asn Asn  Ile Val Leu Gln Ile  Ser Glu Asn Arg Arg  Val Arg Ile 
    1385                 1390                 1395             


Ile Ala  Gly Arg Pro Ile His  Cys Gln Val Pro Gly  Ile Asp His 
    1400                 1405                 1410             


Phe Leu  Val Ser Lys Val Ala  Ile His Ser Thr Leu  Glu Ser Ala 
    1415                 1420                 1425             


Arg Ala  Ile Ser Val Ser His  Ser Gly Leu Leu Phe  Ile Ala Glu 
    1430                 1435                 1440             


Thr Asp  Glu Arg Lys Val Asn  Arg Ile Gln Gln Val  Thr Thr Asn 
    1445                 1450                 1455             


Gly Glu  Ile Tyr Ile Ile Ala  Gly Ala Pro Thr Asp  Cys Asp Cys 
    1460                 1465                 1470             


Lys Ile  Asp Pro Asn Cys Asp  Cys Phe Ser Gly Asp  Gly Gly Tyr 
    1475                 1480                 1485             


Ala Lys  Asp Ala Lys Met Lys  Ala Pro Ser Ser Leu  Ala Val Ser 
    1490                 1495                 1500             


Pro Asp  Gly Thr Leu Tyr Val  Ala Asp Leu Gly Asn  Val Arg Ile 
    1505                 1510                 1515             


Arg Thr  Ile Ser Arg Asn Gln  Ala His Leu Asn Asp  Met Asn Ile 
    1520                 1525                 1530             


Tyr Glu  Ile Ala Ser Pro Ala  Asp Gln Glu Leu Tyr  Gln Phe Thr 
    1535                 1540                 1545             


Val Asn  Gly Thr His Leu His  Thr Leu Asn Leu Ile  Thr Arg Asp 
    1550                 1555                 1560             


Tyr Val  Tyr Asn Phe Thr Tyr  Asn Ser Glu Gly Asp  Leu Gly Ala 
    1565                 1570                 1575             


Ile Thr  Ser Ser Asn Gly Asn  Ser Val His Ile Arg  Arg Asp Ala 
    1580                 1585                 1590             


Gly Gly  Met Pro Leu Trp Leu  Val Val Pro Gly Gly  Gln Val Tyr 
    1595                 1600                 1605             


Trp Leu  Thr Ile Ser Ser Asn  Gly Val Leu Lys Arg  Val Ser Ala 
    1610                 1615                 1620             


Gln Gly  Tyr Asn Leu Ala Leu  Met Thr Tyr Pro Gly  Asn Thr Gly 
    1625                 1630                 1635             


Leu Leu  Ala Thr Lys Ser Asn  Glu Asn Gly Trp Thr  Thr Val Tyr 
    1640                 1645                 1650             


Glu Tyr  Asp Pro Glu Gly His  Leu Thr Asn Ala Thr  Phe Pro Thr 
    1655                 1660                 1665             


Gly Glu  Val Ser Ser Phe His  Ser Asp Leu Glu Lys  Leu Thr Lys 
    1670                 1675                 1680             


Val Glu  Leu Asp Thr Ser Asn  Arg Glu Asn Val Leu  Met Ser Thr 
    1685                 1690                 1695             


Asn Leu  Thr Ala Thr Ser Thr  Ile Tyr Ile Leu Lys  Gln Glu Asn 
    1700                 1705                 1710             


Thr Gln  Ser Thr Tyr Arg Val  Asn Pro Asp Gly Ser  Leu Arg Val 
    1715                 1720                 1725             


Thr Phe  Ala Ser Gly Met Glu  Ile Gly Leu Ser Ser  Glu Pro His 
    1730                 1735                 1740             


Ile Leu  Ala Gly Ala Val Asn  Pro Thr Leu Gly Lys  Cys Asn Ile 
    1745                 1750                 1755             


Ser Leu  Pro Gly Glu His Asn  Ala Asn Leu Ile Glu  Trp Arg Gln 
    1760                 1765                 1770             


Arg Lys  Glu Gln Asn Lys Gly  Asn Val Ser Ala Phe  Glu Arg Arg 
    1775                 1780                 1785             


Leu Arg  Ala His Asn Arg Asn  Leu Leu Ser Ile Asp  Phe Asp His 
    1790                 1795                 1800             


Ile Thr  Arg Thr Gly Lys Ile  Tyr Asp Asp His Arg  Lys Phe Thr 
    1805                 1810                 1815             


Leu Arg  Ile Leu Tyr Asp Gln  Thr Gly Arg Pro Ile  Leu Trp Ser 
    1820                 1825                 1830             


Pro Val  Ser Arg Tyr Asn Glu  Val Asn Ile Thr Tyr  Ser Pro Ser 
    1835                 1840                 1845             


Gly Leu  Val Thr Phe Ile Gln  Arg Gly Thr Trp Asn  Glu Lys Met 
    1850                 1855                 1860             


Glu Tyr  Asp Gln Ser Gly Lys  Ile Ile Ser Arg Thr  Trp Ala Asp 
    1865                 1870                 1875             


Gly Lys  Ile Trp Ser Tyr Thr  Tyr Leu Glu Lys Ser  Val Met Leu 
    1880                 1885                 1890             


Leu Leu  His Ser Gln Arg Arg  Tyr Ile Phe Glu Tyr  Asp Gln Pro 
    1895                 1900                 1905             


Asp Cys  Leu Leu Ser Val Thr  Met Pro Ser Met Val  Arg His Ser 
    1910                 1915                 1920             


Leu Gln  Thr Met Leu Ser Val  Gly Tyr Tyr Arg Asn  Ile Tyr Thr 
    1925                 1930                 1935             


Pro Pro  Asp Ser Ser Thr Ser  Phe Ile Gln Asp Tyr  Ser Arg Asp 
    1940                 1945                 1950             


Gly Arg  Leu Leu Gln Thr Leu  His Leu Gly Thr Gly  Arg Arg Val 
    1955                 1960                 1965             


Leu Tyr  Lys Tyr Thr Lys Gln  Ala Arg Leu Ser Glu  Val Leu Tyr 
    1970                 1975                 1980             


Asp Thr  Thr Gln Val Thr Leu  Thr Tyr Glu Glu Ser  Ser Gly Val 
    1985                 1990                 1995             


Ile Lys  Thr Ile His Leu Met  His Asp Gly Phe Ile  Cys Thr Ile 
    2000                 2005                 2010             


Arg Tyr  Arg Gln Thr Gly Pro  Leu Ile Gly Arg Gln  Ile Phe Arg 
    2015                 2020                 2025             


Phe Ser  Glu Glu Gly Leu Val  Asn Ala Arg Phe Asp  Tyr Ser Tyr 
    2030                 2035                 2040             


Asn Asn  Phe Arg Val Thr Ser  Met Gln Ala Val Ile  Asn Glu Thr 
    2045                 2050                 2055             


Pro Leu  Pro Ile Asp Leu Tyr  Arg Tyr Val Asp Val  Ser Gly Arg 
    2060                 2065                 2070             


Thr Glu  Gln Phe Gly Lys Phe  Ser Val Ile Asn Tyr  Asp Leu Asn 
    2075                 2080                 2085             


Gln Val  Ile Thr Thr Thr Val  Met Lys His Thr Lys  Ile Phe Ser 
    2090                 2095                 2100             


Ala Asn  Gly Gln Val Ile Glu  Val Gln Tyr Glu Ile  Leu Lys Ala 
    2105                 2110                 2115             


Ile Ala  Tyr Trp Met Thr Ile  Gln Tyr Asp Asn Val  Gly Arg Met 
    2120                 2125                 2130             


Val Ile  Cys Asp Ile Arg Val  Gly Val Asp Ala Asn  Ile Thr Arg 
    2135                 2140                 2145             


Tyr Phe  Tyr Glu Tyr Asp Ala  Asp Gly Gln Leu Gln  Thr Val Ser 
    2150                 2155                 2160             


Val Asn  Asp Lys Thr Gln Trp  Arg Tyr Ser Tyr Asp  Leu Asn Gly 
    2165                 2170                 2175             


Asn Ile  Asn Leu Leu Ser His  Gly Lys Ser Ala Arg  Leu Thr Pro 
    2180                 2185                 2190             


Leu Arg  Tyr Asp Leu Arg Asp  Arg Ile Thr Arg Leu  Gly Glu Ile 
    2195                 2200                 2205             


Gln Tyr  Lys Met Asp Glu Asp  Gly Phe Leu Arg Gln  Arg Gly Asn 
    2210                 2215                 2220             


Asp Ile  Phe Glu Tyr Asn Ser  Asn Gly Leu Leu Gln  Lys Ala Tyr 
    2225                 2230                 2235             


Asn Lys  Ala Ser Gly Trp Thr  Val Gln Tyr Tyr Tyr  Asp Gly Leu 
    2240                 2245                 2250             


Gly Arg  Arg Val Ala Ser Lys  Ser Ser Leu Gly Gln  His Leu Gln 
    2255                 2260                 2265             


Phe Phe  Tyr Ala Asp Leu Thr  Asn Pro Ile Arg Val  Thr His Leu 
    2270                 2275                 2280             


Tyr Asn  His Thr Ser Ser Glu  Ile Thr Ser Leu Tyr  Tyr Asp Leu 
    2285                 2290                 2295             


Gln Gly  His Leu Ile Ala Met  Glu Leu Ser Ser Gly  Glu Glu Tyr 
    2300                 2305                 2310             


Tyr Val  Ala Cys Asp Asn Thr  Gly Thr Pro Leu Ala  Val Phe Ser 
    2315                 2320                 2325             


Ser Arg  Gly Gln Val Ile Lys  Glu Ile Leu Tyr Thr  Pro Tyr Gly 
    2330                 2335                 2340             


Asp Ile  Tyr His Asp Thr Tyr  Pro Asp Phe Gln Val  Ile Ile Gly 
    2345                 2350                 2355             


Phe His  Gly Gly Leu Tyr Asp  Phe Leu Thr Lys Leu  Val His Leu 
    2360                 2365                 2370             


Gly Gln  Arg Asp Tyr Asp Val  Val Ala Gly Arg Trp  Thr Thr Pro 
    2375                 2380                 2385             


Asn His  His Ile Trp Lys Gln  Leu Asn Leu Leu Pro  Lys Pro Phe 
    2390                 2395                 2400             


Asn Leu  Tyr Ser Phe Glu Asn  Asn Tyr Pro Val Gly  Lys Ile Gln 
    2405                 2410                 2415             


Asp Val  Ala Lys Tyr Thr Thr  Asp Ile Arg Ser Trp  Leu Glu Leu 
    2420                 2425                 2430             


Phe Gly  Phe Gln Leu His Asn  Val Leu Pro Gly Phe  Pro Lys Pro 
    2435                 2440                 2445             


Glu Leu  Glu Asn Leu Glu Leu  Thr Tyr Glu Leu Leu  Arg Leu Gln 
    2450                 2455                 2460             


Thr Lys  Thr Gln Glu Trp Asp  Pro Gly Lys Thr Ile  Leu Gly Ile 
    2465                 2470                 2475             


Gln Cys  Glu Leu Gln Lys Gln  Leu Arg Asn Phe Ile  Ser Leu Asp 
    2480                 2485                 2490             


Gln Leu  Pro Met Thr Pro Arg  Tyr Asn Asp Gly Arg  Cys Leu Glu 
    2495                 2500                 2505             


Gly Gly  Lys Gln Pro Arg Phe  Ala Ala Val Pro Ser  Val Phe Gly 
    2510                 2515                 2520             


Lys Gly  Ile Lys Phe Ala Ile  Lys Asp Gly Ile Val  Thr Ala Asp 
    2525                 2530                 2535             


Ile Ile  Gly Val Ala Asn Glu  Asp Ser Arg Arg Leu  Ala Ala Ile 
    2540                 2545                 2550             


Leu Asn  Asn Ala His Tyr Leu  Glu Asn Leu His Phe  Thr Ile Glu 
    2555                 2560                 2565             


Gly Arg  Asp Thr His Tyr Phe  Ile Lys Leu Gly Ser  Leu Glu Glu 
    2570                 2575                 2580             


Asp Leu  Val Leu Ile Gly Asn  Thr Gly Gly Arg Arg  Ile Leu Glu 
    2585                 2590                 2595             


Asn Gly  Val Asn Val Thr Val  Ser Gln Met Thr Ser  Val Leu Asn 
    2600                 2605                 2610             


Gly Arg  Thr Arg Arg Phe Ala  Asp Ile Gln Leu Gln  His Gly Ala 
    2615                 2620                 2625             


Leu Cys  Phe Asn Ile Arg Tyr  Gly Thr Thr Val Glu  Glu Glu Lys 
    2630                 2635                 2640             


Asn His  Val Leu Glu Ile Ala  Arg Gln Arg Ala Val  Ala Gln Ala 
    2645                 2650                 2655             


Trp Thr  Lys Glu Gln Arg Arg  Leu Gln Glu Gly Glu  Glu Gly Ile 
    2660                 2665                 2670             


Arg Ala  Trp Thr Glu Gly Glu  Lys Gln Gln Leu Leu  Ser Thr Gly 
    2675                 2680                 2685             


Arg Val  Gln Gly Tyr Asp Gly  Tyr Phe Val Leu Ser  Val Glu Gln 
    2690                 2695                 2700             


Tyr Leu  Glu Leu Ser Asp Ser  Ala Asn Asn Ile His  Phe Met Arg 
    2705                 2710                 2715             


Gln Ser  Glu Ile Gly Arg Arg  
    2720                 2725 


<210>  3897
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  3897

Met Arg Leu Thr Arg Lys Arg Leu Cys Ser Phe Leu Ile Ala Leu Tyr 
1               5                   10                  15      


Cys Leu Phe Ser Leu Tyr Ala Ala Tyr His Val Phe Phe Gly Arg Arg 
            20                  25                  30          


Arg Gln Ala Pro Ala Gly Ser Pro Arg Gly Leu Arg Lys Gly Ala Ala 
        35                  40                  45              


Pro Ala Arg Glu Arg Arg Gly Arg Glu Gln Ser Thr Leu Glu Ser Glu 
    50                  55                  60                  


Glu Trp Asn Pro Trp Glu Gly Asp Glu Lys Asn Glu Gln Gln His Arg 
65                  70                  75                  80  


Phe Lys Thr Ser Leu Gln Ile Leu Asp Lys Ser Thr Lys Gly Lys Thr 
                85                  90                  95      


Asp Leu Ser Val Gln Ile Trp Gly Lys Ala Ala Ile Gly Leu Tyr Leu 
            100                 105                 110         


Trp Glu His Ile Phe Glu Gly Leu Leu Asp Pro Ser Asp Val Thr Ala 
        115                 120                 125             


Gln Trp Arg Glu Gly Lys Ser Ile Val Gly Arg Thr Gln Tyr Ser Phe 
    130                 135                 140                 


Ile Thr Gly Pro Ala Val Ile Pro Gly Tyr Phe Ser Val Asp Val Asn 
145                 150                 155                 160 


Asn Val Val Leu Ile Leu Asn Gly Arg Glu Lys Ala Lys Ile Phe Tyr 
                165                 170                 175     


Ala Thr Gln Trp Leu Leu Tyr Ala Gln Asn Leu Val Gln Ile Gln Lys 
            180                 185                 190         


Leu Gln His Leu Ala Val Val Leu Leu Gly Asn Glu His Cys Asp Asn 
        195                 200                 205             


Glu Trp Ile Asn Pro Phe Leu Lys Arg Asn Gly Gly Phe Val Glu Leu 
    210                 215                 220                 


Leu Phe Ile Ile Tyr Asp Ser Pro Trp Ile Asn Asp Val Asp Val Phe 
225                 230                 235                 240 


Gln Trp Pro Leu Gly Val Ala Thr Tyr Arg Asn Phe Pro Val Val Glu 
                245                 250                 255     


Ala Ser Trp Ser Met Leu His Asp Glu Arg Pro Tyr Leu Cys Asn Phe 
            260                 265                 270         


Leu Gly Thr Ile Tyr Glu Asn Ser Ser Arg Gln Ala Leu Met Asn Ile 
        275                 280                 285             


Leu Lys Lys Asp Gly Asn Asp Lys Leu Cys Trp Val Ser Ala Arg Glu 
    290                 295                 300                 


His Trp Gln Pro Gln Glu Thr Asn Glu Ser Leu Lys Asn Tyr Gln Asp 
305                 310                 315                 320 


Ala Leu Leu Gln Ser Asp Leu Thr Leu Cys Pro Val Gly Val Asn Thr 
                325                 330                 335     


Glu Cys Tyr Arg Ile Tyr Glu Ala Cys Ser Tyr Gly Ser Ile Pro Val 
            340                 345                 350         


Val Glu Asp Val Met Thr Ala Gly Asn Cys Gly Asn Thr Ser Val His 
        355                 360                 365             


His Gly Ala Pro Leu Gln Leu Leu Lys Ser Met Gly Ala Pro Phe Ile 
    370                 375                 380                 


Phe Ile Lys Asn Trp Lys Glu Leu Pro Ala Val Leu Glu Lys Glu Lys 
385                 390                 395                 400 


Thr Ile Ile Leu Gln Glu Lys Ile Glu Arg Arg Lys Met Leu Leu Gln 
                405                 410                 415     


Trp Tyr Gln His Phe Lys Thr Glu Leu Lys Met Lys Phe Thr Asn Ile 
            420                 425                 430         


Leu Glu Ser Ser Phe Leu Met Asn Asn Lys Ser 
        435                 440             


<210>  3898
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  3898

Met Lys Tyr Leu Arg His Arg Arg Pro Asn Ala Thr Leu Ile Leu Ala 
1               5                   10                  15      


Ile Gly Ala Phe Thr Leu Leu Leu Phe Ser Leu Leu Val Ser Pro Pro 
            20                  25                  30          


Thr Cys Lys Val Gln Glu Gln Pro Pro Ala Ile Pro Glu Ala Leu Ala 
        35                  40                  45              


Trp Pro Thr Pro Pro Thr Arg Pro Ala Pro Ala Pro Cys His Ala Asn 
    50                  55                  60                  


Thr Ser Met Val Thr His Pro Asp Phe Ala Thr Gln Pro Gln His Val 
65                  70                  75                  80  


Gln Asn Phe Leu Leu Tyr Arg His Cys Arg His Phe Pro Leu Leu Gln 
                85                  90                  95      


Asp Val Pro Pro Ser Lys Cys Ala Gln Pro Val Phe Leu Leu Leu Val 
            100                 105                 110         


Ile Lys Ser Ser Pro Ser Asn Tyr Val Arg Arg Glu Leu Leu Arg Arg 
        115                 120                 125             


Thr Trp Gly Arg Glu Arg Lys Val Arg Gly Leu Gln Leu Arg Leu Leu 
    130                 135                 140                 


Phe Leu Val Gly Thr Ala Ser Asn Pro His Glu Ala Arg Lys Val Asn 
145                 150                 155                 160 


Arg Leu Leu Glu Leu Glu Ala Gln Thr His Gly Asp Ile Leu Gln Trp 
                165                 170                 175     


Asp Phe His Asp Ser Phe Phe Asn Leu Thr Leu Lys Gln Val Leu Phe 
            180                 185                 190         


Leu Gln Trp Gln Glu Thr Arg Cys Ala Asn Ala Ser Phe Val Leu Asn 
        195                 200                 205             


Gly Asp Asp Asp Val Phe Ala His Thr Asp Asn Met Val Phe Tyr Leu 
    210                 215                 220                 


Gln Asp His Asp Pro Gly Arg His Leu Phe Val Gly Gln Leu Ile Gln 
225                 230                 235                 240 


Asn Val Gly Pro Ile Arg Ala Phe Trp Ser Lys Tyr Tyr Val Pro Glu 
                245                 250                 255     


Val Val Thr Gln Asn Glu Arg Tyr Pro Pro Tyr Cys Gly Gly Gly Gly 
            260                 265                 270         


Phe Leu Leu Ser Arg Phe Thr Ala Ala Ala Leu Arg Arg Ala Ala His 
        275                 280                 285             


Val Leu Asp Ile Phe Pro Ile Asp Asp Val Phe Leu Gly Met Cys Leu 
    290                 295                 300                 


Glu Leu Glu Gly Leu Lys Pro Ala Ser His Ser Gly Ile Arg Thr Ser 
305                 310                 315                 320 


Gly Val Arg Ala Pro Ser Gln Arg Leu Ser Ser Phe Asp Pro Cys Phe 
                325                 330                 335     


Tyr Arg Asp Leu Leu Leu Val His Arg Phe Leu Pro Tyr Glu Met Leu 
            340                 345                 350         


Leu Met Trp Asp Ala Leu Asn Gln Pro Asn Leu Thr Cys Gly Asn Gln 
        355                 360                 365             


Thr Gln Ile Tyr 
    370         


<210>  3899
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  3899

Met Ser Asp Ser Lys Glu Pro Arg Val Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Asp Pro Thr Thr Ser Gly Ile Arg Leu Phe Pro Arg Asp Phe Gln 
            20                  25                  30          


Phe Gln Gln Ile His Gly His Lys Ser Ser Thr Gly Cys Leu Gly His 
        35                  40                  45              


Gly Ala Leu Val Leu Gln Leu Leu Ser Phe Met Leu Leu Ala Gly Val 
    50                  55                  60                  


Leu Val Ala Ile Leu Val Gln Val Ser Lys Val Pro Ser Ser Leu Ser 
65                  70                  75                  80  


Gln Glu Gln Ser Glu Gln Asp Ala Ile Tyr Gln Asn Leu Thr Gln Leu 
                85                  90                  95      


Lys Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys Leu Gln Glu Ile 
            100                 105                 110         


Tyr Gln Glu Leu Thr Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Glu 
        115                 120                 125             


Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr Arg Leu Lys Ala 
    130                 135                 140                 


Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln 
145                 150                 155                 160 


Glu Leu Thr Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser 
                165                 170                 175     


Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr Arg Leu Lys Ala Ala Val 
            180                 185                 190         


Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu 
        195                 200                 205             


Thr Glu Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu 
    210                 215                 220                 


Gln Glu Ile Tyr Gln Glu Leu Thr Gln Leu Lys Ala Ala Val Gly Glu 
225                 230                 235                 240 


Leu Pro Asp Gln Ser Lys Gln Gln Gln Ile Tyr Gln Glu Leu Thr Asp 
                245                 250                 255     


Leu Lys Thr Ala Phe Glu Arg Leu Cys Arg His Cys Pro Lys Asp Trp 
            260                 265                 270         


Thr Phe Phe Gln Gly Asn Cys Tyr Phe Met Ser Asn Ser Gln Arg Asn 
        275                 280                 285             


Trp His Asp Ser Val Thr Ala Cys Gln Glu Val Arg Ala Gln Leu Val 
    290                 295                 300                 


Val Ile Lys Thr Ala Glu Glu Gln Asn Phe Leu Gln Leu Gln Thr Ser 
305                 310                 315                 320 


Arg Ser Asn Arg Phe Ser Trp Met Gly Leu Ser Asp Leu Asn Gln Glu 
                325                 330                 335     


Gly Thr Trp Gln Trp Val Asp Gly Ser Pro Leu Ser Pro Ser Phe Gln 
            340                 345                 350         


Arg Tyr Trp Asn Ser Gly Glu Pro Asn Asn Ser Gly Asn Glu Asp Cys 
        355                 360                 365             


Ala Glu Phe Ser Gly Ser Gly Trp Asn Asp Asn Arg Cys Asp Val Asp 
    370                 375                 380                 


Asn Tyr Trp Ile Cys Lys Lys Pro Ala Ala Cys Phe Arg Asp Glu 
385                 390                 395                 


<210>  3900
<211>  716
<212>  PRT
<213>  Homo sapiens

<400>  3900

Met Phe Ser Leu Ser Ser Thr Val Gln Pro Gln Val Thr Val Pro Leu 
1               5                   10                  15      


Ser His Leu Ile Asn Ala Phe His Thr Pro Lys Asn Thr Ser Val Ser 
            20                  25                  30          


Leu Ser Gly Val Ser Val Ser Gln Asn Gln His Arg Asp Val Val Pro 
        35                  40                  45              


Glu His Glu Ala Pro Ser Ser Glu Pro Ser Leu Asn Leu Arg Asp Leu 
    50                  55                  60                  


Gly Leu Ser Glu Leu Lys Ile Gly Gln Ile Asp Gln Leu Val Glu Asn 
65                  70                  75                  80  


Leu Leu Pro Gly Phe Cys Lys Gly Lys Asn Ile Ser Ser His Trp His 
                85                  90                  95      


Thr Ser His Val Ser Ala Gln Ser Phe Phe Glu Asn Lys Tyr Gly Asn 
            100                 105                 110         


Leu Asp Ile Phe Ser Thr Leu Arg Ser Ser Cys Leu Tyr Arg His His 
        115                 120                 125             


Ser Arg Ala Leu Gln Ser Ile Cys Ser Asp Leu Gln Tyr Trp Pro Val 
    130                 135                 140                 


Phe Ile Gln Ser Arg Gly Phe Lys Thr Leu Lys Ser Arg Thr Arg Arg 
145                 150                 155                 160 


Leu Gln Ser Thr Ser Glu Arg Leu Ala Glu Thr Gln Asn Ile Ala Pro 
                165                 170                 175     


Ser Phe Val Lys Gly Phe Leu Leu Arg Asp Arg Gly Ser Asp Val Glu 
            180                 185                 190         


Ser Leu Asp Lys Leu Met Lys Thr Lys Asn Ile Pro Glu Ala His Gln 
        195                 200                 205             


Asp Ala Phe Lys Thr Gly Phe Ala Glu Gly Phe Leu Lys Ala Gln Ala 
    210                 215                 220                 


Leu Thr Gln Lys Thr Asn Asp Ser Leu Arg Arg Thr Arg Leu Ile Leu 
225                 230                 235                 240 


Phe Val Leu Leu Leu Phe Gly Ile Tyr Gly Leu Leu Lys Asn Pro Phe 
                245                 250                 255     


Leu Ser Val Arg Phe Arg Thr Thr Thr Gly Leu Asp Ser Ala Val Asp 
            260                 265                 270         


Pro Val Gln Met Lys Asn Val Thr Phe Glu His Val Lys Gly Val Glu 
        275                 280                 285             


Glu Ala Lys Gln Glu Leu Gln Glu Val Val Glu Phe Leu Lys Asn Pro 
    290                 295                 300                 


Gln Lys Phe Thr Ile Leu Gly Gly Lys Leu Pro Lys Gly Ile Leu Leu 
305                 310                 315                 320 


Val Gly Pro Pro Gly Thr Gly Lys Thr Leu Leu Ala Arg Ala Val Ala 
                325                 330                 335     


Gly Glu Ala Asp Val Pro Phe Tyr Tyr Ala Ser Gly Ser Glu Phe Asp 
            340                 345                 350         


Glu Met Phe Val Gly Val Gly Ala Ser Arg Ile Arg Asn Leu Phe Arg 
        355                 360                 365             


Glu Ala Lys Ala Asn Ala Pro Cys Val Ile Phe Ile Asp Glu Leu Asp 
    370                 375                 380                 


Ser Val Gly Gly Lys Arg Ile Glu Ser Pro Met His Pro Tyr Ser Arg 
385                 390                 395                 400 


Gln Thr Ile Asn Gln Leu Leu Ala Glu Met Asp Gly Phe Lys Pro Asn 
                405                 410                 415     


Glu Gly Val Ile Ile Ile Gly Ala Thr Asn Phe Pro Glu Ala Leu Asp 
            420                 425                 430         


Asn Ala Leu Ile Arg Pro Gly Arg Phe Asp Met Gln Val Thr Val Pro 
        435                 440                 445             


Arg Pro Asp Val Lys Gly Arg Thr Glu Ile Leu Lys Trp Tyr Leu Asn 
    450                 455                 460                 


Lys Ile Lys Phe Asp Gln Ser Val Asp Pro Glu Ile Ile Ala Arg Gly 
465                 470                 475                 480 


Thr Val Gly Phe Ser Gly Ala Glu Leu Glu Asn Leu Val Asn Gln Ala 
                485                 490                 495     


Ala Leu Lys Ala Ala Val Asp Gly Lys Glu Met Val Thr Met Lys Glu 
            500                 505                 510         


Leu Glu Phe Ser Lys Asp Lys Ile Leu Met Gly Pro Glu Arg Arg Ser 
        515                 520                 525             


Val Glu Ile Asp Asn Lys Asn Lys Thr Ile Thr Ala Tyr His Glu Ser 
    530                 535                 540                 


Gly His Ala Ile Ile Ala Tyr Tyr Thr Lys Asp Ala Met Pro Ile Asn 
545                 550                 555                 560 


Lys Ala Thr Ile Met Pro Arg Gly Pro Thr Leu Gly His Val Ser Leu 
                565                 570                 575     


Leu Pro Glu Asn Asp Arg Trp Asn Glu Thr Arg Ala Gln Leu Leu Ala 
            580                 585                 590         


Gln Met Asp Val Ser Met Gly Gly Arg Val Ala Glu Glu Leu Ile Phe 
        595                 600                 605             


Gly Thr Asp His Ile Thr Thr Gly Ala Ser Ser Asp Phe Asp Asn Ala 
    610                 615                 620                 


Thr Lys Ile Ala Lys Arg Met Val Thr Lys Phe Gly Met Ser Glu Lys 
625                 630                 635                 640 


Leu Gly Val Met Thr Tyr Ser Asp Thr Gly Lys Leu Ser Pro Glu Thr 
                645                 650                 655     


Gln Ser Ala Ile Glu Gln Glu Ile Arg Ile Leu Leu Arg Asp Ser Tyr 
            660                 665                 670         


Glu Arg Ala Lys His Ile Leu Lys Thr His Ala Lys Glu His Lys Asn 
        675                 680                 685             


Leu Ala Glu Ala Leu Leu Thr Tyr Glu Thr Leu Asp Ala Lys Glu Ile 
    690                 695                 700                 


Gln Ile Val Leu Glu Gly Lys Lys Leu Glu Val Arg 
705                 710                 715     


<210>  3901
<211>  775
<212>  PRT
<213>  Homo sapiens

<400>  3901

Met Leu Gln Gly Leu Leu Pro Val Ser Leu Leu Leu Ser Val Ala Val 
1               5                   10                  15      


Ser Ala Ile Lys Glu Leu Pro Gly Val Lys Lys Tyr Glu Val Val Tyr 
            20                  25                  30          


Pro Ile Arg Leu His Pro Leu His Lys Arg Glu Ala Lys Glu Pro Glu 
        35                  40                  45              


Gln Gln Glu Gln Phe Glu Thr Glu Leu Lys Tyr Lys Met Thr Ile Asn 
    50                  55                  60                  


Gly Lys Ile Ala Val Leu Tyr Leu Lys Lys Asn Lys Asn Leu Leu Ala 
65                  70                  75                  80  


Pro Gly Tyr Thr Glu Thr Tyr Tyr Asn Ser Thr Gly Lys Glu Ile Thr 
                85                  90                  95      


Thr Ser Pro Gln Ile Met Asp Asp Cys Tyr Tyr Gln Gly His Ile Leu 
            100                 105                 110         


Asn Glu Lys Val Ser Asp Ala Ser Ile Ser Thr Cys Arg Gly Leu Arg 
        115                 120                 125             


Gly Tyr Phe Ser Gln Gly Asp Gln Arg Tyr Phe Ile Glu Pro Leu Ser 
    130                 135                 140                 


Pro Ile His Arg Asp Gly Gln Glu His Ala Leu Phe Lys Tyr Asn Pro 
145                 150                 155                 160 


Asp Glu Lys Asn Tyr Asp Ser Thr Cys Gly Met Asp Gly Val Leu Trp 
                165                 170                 175     


Ala His Asp Leu Gln Gln Asn Ile Ala Leu Pro Ala Thr Lys Leu Val 
            180                 185                 190         


Lys Leu Lys Asp Arg Lys Val Gln Glu His Glu Lys Tyr Ile Glu Tyr 
        195                 200                 205             


Tyr Leu Val Leu Asp Asn Gly Glu Phe Lys Arg Tyr Asn Glu Asn Gln 
    210                 215                 220                 


Asp Glu Ile Arg Lys Arg Val Phe Glu Met Ala Asn Tyr Val Asn Met 
225                 230                 235                 240 


Leu Tyr Lys Lys Leu Asn Thr His Val Ala Leu Val Gly Met Glu Ile 
                245                 250                 255     


Trp Thr Asp Lys Asp Lys Ile Lys Ile Thr Pro Asn Ala Ser Phe Thr 
            260                 265                 270         


Leu Glu Asn Phe Ser Lys Trp Arg Gly Ser Val Leu Ser Arg Arg Lys 
        275                 280                 285             


Arg His Asp Ile Ala Gln Leu Ile Thr Ala Thr Glu Leu Ala Gly Thr 
    290                 295                 300                 


Thr Val Gly Leu Ala Phe Met Ser Thr Met Cys Ser Pro Tyr Ser Val 
305                 310                 315                 320 


Gly Val Val Gln Asp His Ser Asp Asn Leu Leu Arg Val Ala Gly Thr 
                325                 330                 335     


Met Ala His Glu Met Gly His Asn Phe Gly Met Phe His Asp Asp Tyr 
            340                 345                 350         


Ser Cys Lys Cys Pro Ser Thr Ile Cys Val Met Asp Lys Ala Leu Ser 
        355                 360                 365             


Phe Tyr Ile Pro Thr Asp Phe Ser Ser Cys Ser Arg Leu Ser Tyr Asp 
    370                 375                 380                 


Lys Phe Phe Glu Asp Lys Leu Ser Asn Cys Leu Phe Asn Ala Pro Leu 
385                 390                 395                 400 


Pro Thr Asp Ile Ile Ser Thr Pro Ile Cys Gly Asn Gln Leu Val Glu 
                405                 410                 415     


Met Gly Glu Asp Cys Asp Cys Gly Thr Ser Glu Glu Cys Thr Asn Ile 
            420                 425                 430         


Cys Cys Asp Ala Lys Thr Cys Lys Ile Lys Ala Thr Phe Gln Cys Ala 
        435                 440                 445             


Leu Gly Glu Cys Cys Glu Lys Cys Gln Phe Lys Lys Ala Gly Met Val 
    450                 455                 460                 


Cys Arg Pro Ala Lys Asp Glu Cys Asp Leu Pro Glu Met Cys Asn Gly 
465                 470                 475                 480 


Lys Ser Gly Asn Cys Pro Asp Asp Arg Phe Gln Val Asn Gly Phe Pro 
                485                 490                 495     


Cys His His Gly Lys Gly His Cys Leu Met Gly Thr Cys Pro Thr Leu 
            500                 505                 510         


Gln Glu Gln Cys Thr Glu Leu Trp Gly Pro Gly Thr Glu Val Ala Asp 
        515                 520                 525             


Lys Ser Cys Tyr Asn Arg Asn Glu Gly Gly Ser Lys Tyr Gly Tyr Cys 
    530                 535                 540                 


Arg Arg Val Asp Asp Thr Leu Ile Pro Cys Lys Ala Asn Asp Thr Met 
545                 550                 555                 560 


Cys Gly Lys Leu Phe Cys Gln Gly Gly Ser Asp Asn Leu Pro Trp Lys 
                565                 570                 575     


Gly Arg Ile Val Thr Phe Leu Thr Cys Lys Thr Phe Asp Pro Glu Asp 
            580                 585                 590         


Thr Ser Gln Glu Ile Gly Met Val Ala Asn Gly Thr Lys Cys Gly Asp 
        595                 600                 605             


Asn Lys Val Cys Ile Asn Ala Glu Cys Val Asp Ile Glu Lys Ala Tyr 
    610                 615                 620                 


Lys Ser Thr Asn Cys Ser Ser Lys Cys Lys Gly His Ala Val Cys Asp 
625                 630                 635                 640 


His Glu Leu Gln Cys Gln Cys Glu Glu Gly Trp Ile Pro Pro Asp Cys 
                645                 650                 655     


Asp Asp Ser Ser Val Val Phe His Phe Ser Ile Val Val Gly Val Leu 
            660                 665                 670         


Phe Pro Met Ala Val Ile Phe Val Val Val Ala Met Val Ile Arg His 
        675                 680                 685             


Gln Ser Ser Arg Glu Lys Gln Lys Lys Asp Gln Arg Pro Leu Ser Thr 
    690                 695                 700                 


Thr Gly Thr Arg Pro His Lys Gln Lys Arg Lys Pro Gln Met Val Lys 
705                 710                 715                 720 


Ala Val Gln Pro Gln Glu Met Ser Gln Met Lys Pro His Val Tyr Asp 
                725                 730                 735     


Leu Pro Val Glu Gly Asn Glu Pro Pro Ala Ser Phe His Lys Asp Thr 
            740                 745                 750         


Asn Ala Leu Pro Pro Thr Val Phe Lys Asp Asn Pro Val Ser Thr Pro 
        755                 760                 765             


Lys Asp Ser Asn Pro Lys Ala 
    770                 775 


<210>  3902
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  3902

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr 
            20                  25                  30          


Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
        35                  40                  45              


Leu Leu Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu Ile 
    50                  55                  60                  


Val Gly Ala Val Phe Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln 
65                  70                  75                  80  


Glu Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly 
                85                  90              


<210>  3903
<211>  820
<212>  PRT
<213>  Homo sapiens

<400>  3903

Met Lys Met Leu Leu Leu Leu His Cys Leu Gly Val Phe Leu Ser Cys 
1               5                   10                  15      


Ser Gly His Ile Gln Asp Glu His Pro Gln Tyr His Ser Pro Pro Asp 
            20                  25                  30          


Val Val Ile Pro Val Arg Ile Thr Gly Thr Thr Arg Gly Met Thr Pro 
        35                  40                  45              


Pro Gly Trp Leu Ser Tyr Ile Leu Pro Phe Gly Gly Gln Lys His Ile 
    50                  55                  60                  


Ile His Ile Lys Val Lys Lys Leu Leu Phe Ser Lys His Leu Pro Val 
65                  70                  75                  80  


Phe Thr Tyr Thr Asp Gln Gly Ala Ile Leu Glu Asp Gln Pro Phe Val 
                85                  90                  95      


Gln Asn Asn Cys Tyr Tyr His Gly Tyr Val Glu Gly Asp Pro Glu Ser 
            100                 105                 110         


Leu Val Ser Leu Ser Thr Cys Phe Gly Gly Phe Gln Gly Ile Leu Gln 
        115                 120                 125             


Ile Asn Asp Phe Ala Tyr Glu Ile Lys Pro Leu Ala Phe Ser Thr Thr 
    130                 135                 140                 


Phe Glu His Leu Val Tyr Lys Met Asp Ser Glu Glu Lys Gln Phe Ser 
145                 150                 155                 160 


Thr Met Arg Ser Gly Phe Met Gln Asn Glu Ile Thr Cys Arg Met Glu 
                165                 170                 175     


Phe Glu Glu Ile Asp Asn Ser Thr Gln Lys Gln Ser Ser Tyr Val Gly 
            180                 185                 190         


Trp Trp Ile His Phe Arg Ile Val Glu Ile Val Val Val Ile Asp Asn 
        195                 200                 205             


Tyr Leu Tyr Ile Arg Tyr Glu Arg Asn Asp Ser Lys Leu Leu Glu Asp 
    210                 215                 220                 


Leu Tyr Val Ile Val Asn Ile Val Asp Ser Ile Leu Asp Val Ile Gly 
225                 230                 235                 240 


Val Lys Val Leu Leu Phe Gly Leu Glu Ile Trp Thr Asn Lys Asn Leu 
                245                 250                 255     


Ile Val Val Asp Asp Val Arg Lys Ser Val His Leu Tyr Cys Lys Trp 
            260                 265                 270         


Lys Ser Glu Asn Ile Thr Pro Arg Met Gln His Asp Thr Ser His Leu 
        275                 280                 285             


Phe Thr Thr Leu Gly Leu Arg Gly Leu Ser Gly Ile Gly Ala Phe Arg 
    290                 295                 300                 


Gly Met Cys Thr Pro His Arg Ser Cys Ala Ile Val Thr Phe Met Asn 
305                 310                 315                 320 


Lys Thr Leu Gly Thr Phe Ser Ile Ala Val Ala His His Leu Gly His 
                325                 330                 335     


Asn Leu Gly Met Asn His Asp Glu Asp Thr Cys Arg Cys Ser Gln Pro 
            340                 345                 350         


Arg Cys Ile Met His Glu Gly Asn Pro Pro Ile Thr Lys Phe Ser Asn 
        355                 360                 365             


Cys Ser Tyr Gly Asp Phe Trp Glu Tyr Thr Val Glu Arg Thr Lys Cys 
    370                 375                 380                 


Leu Leu Glu Thr Val His Thr Lys Asp Ile Phe Asn Val Lys Arg Cys 
385                 390                 395                 400 


Gly Asn Gly Val Val Glu Glu Gly Glu Glu Cys Asp Cys Gly Pro Leu 
                405                 410                 415     


Lys His Cys Ala Lys Asp Pro Cys Cys Leu Ser Asn Cys Thr Leu Thr 
            420                 425                 430         


Asp Gly Ser Thr Cys Ala Phe Gly Leu Cys Cys Lys Asp Cys Lys Phe 
        435                 440                 445             


Leu Pro Ser Gly Lys Val Cys Arg Lys Glu Val Asn Glu Cys Asp Leu 
    450                 455                 460                 


Pro Glu Trp Cys Asn Gly Thr Ser His Lys Cys Pro Asp Asp Phe Tyr 
465                 470                 475                 480 


Val Glu Asp Gly Ile Pro Cys Lys Glu Arg Gly Tyr Cys Tyr Glu Lys 
                485                 490                 495     


Ser Cys His Asp Arg Asn Glu Gln Cys Arg Arg Ile Phe Gly Ala Gly 
            500                 505                 510         


Ala Asn Thr Ala Ser Glu Thr Cys Tyr Lys Glu Leu Asn Thr Leu Gly 
        515                 520                 525             


Asp Arg Val Gly His Cys Gly Ile Lys Asn Ala Thr Tyr Ile Lys Cys 
    530                 535                 540                 


Asn Ile Ser Asp Val Gln Cys Gly Arg Ile Gln Cys Glu Asn Val Thr 
545                 550                 555                 560 


Glu Ile Pro Asn Met Ser Asp His Thr Thr Val His Trp Ala Arg Phe 
                565                 570                 575     


Asn Asp Ile Met Cys Trp Ser Thr Asp Tyr His Leu Gly Met Lys Gly 
            580                 585                 590         


Pro Asp Ile Gly Glu Val Lys Asp Gly Thr Glu Cys Gly Ile Asp His 
        595                 600                 605             


Ile Cys Ile His Arg His Cys Val His Ile Thr Ile Leu Asn Ser Asn 
    610                 615                 620                 


Cys Ser Pro Ala Phe Cys Asn Lys Arg Gly Ile Cys Asn Asn Lys His 
625                 630                 635                 640 


His Cys His Cys Asn Tyr Leu Trp Asp Pro Pro Asn Cys Leu Ile Lys 
                645                 650                 655     


Gly Tyr Gly Gly Ser Val Asp Ser Gly Pro Pro Pro Lys Arg Lys Lys 
            660                 665                 670         


Lys Lys Lys Phe Cys Tyr Leu Cys Ile Leu Leu Leu Ile Val Leu Phe 
        675                 680                 685             


Ile Leu Leu Cys Cys Leu Tyr Arg Leu Cys Lys Lys Ser Lys Pro Ile 
    690                 695                 700                 


Lys Lys Gln Gln Asp Val Gln Thr Pro Ser Ala Lys Glu Glu Glu Lys 
705                 710                 715                 720 


Ile Gln Arg Arg Pro His Glu Leu Pro Pro Gln Ser Gln Pro Trp Val 
                725                 730                 735     


Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser His Pro 
            740                 745                 750         


Gln Val Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser 
        755                 760                 765             


Gln Pro Arg Val Met Pro Ser Gln Ser Gln Pro Pro Val Met Pro Ser 
    770                 775                 780                 


Gln Ser His Pro Gln Leu Thr Pro Ser Gln Ser Gln Pro Pro Val Thr 
785                 790                 795                 800 


Pro Ser Gln Arg Gln Pro Gln Leu Met Pro Ser Gln Ser Gln Pro Pro 
                805                 810                 815     


Val Thr Pro Ser 
            820 


<210>  3904
<211>  487
<212>  PRT
<213>  Homo sapiens

<400>  3904

Met Gly Asp Thr Gly Leu Arg Lys Arg Arg Glu Asp Glu Lys Ser Ile 
1               5                   10                  15      


Gln Ser Gln Glu Pro Lys Thr Thr Ser Leu Gln Lys Glu Leu Gly Leu 
            20                  25                  30          


Ile Ser Gly Ile Ser Ile Ile Val Gly Thr Ile Ile Gly Ser Gly Ile 
        35                  40                  45              


Phe Val Ser Pro Lys Ser Val Leu Ser Asn Thr Glu Ala Val Gly Pro 
    50                  55                  60                  


Cys Leu Ile Ile Trp Ala Ala Cys Gly Val Leu Ala Thr Leu Gly Ala 
65                  70                  75                  80  


Leu Cys Phe Ala Glu Leu Gly Thr Met Ile Thr Lys Ser Gly Gly Glu 
                85                  90                  95      


Tyr Pro Tyr Leu Met Glu Ala Tyr Gly Pro Ile Pro Ala Tyr Leu Phe 
            100                 105                 110         


Ser Trp Ala Ser Leu Ile Val Ile Lys Pro Thr Ser Phe Ala Ile Ile 
        115                 120                 125             


Cys Leu Ser Phe Ser Glu Tyr Val Cys Ala Pro Phe Tyr Val Gly Cys 
    130                 135                 140                 


Lys Pro Pro Gln Ile Val Val Lys Cys Leu Ala Ala Ala Ala Ile Leu 
145                 150                 155                 160 


Phe Ile Ser Thr Val Asn Ser Leu Ser Val Arg Leu Gly Ser Tyr Val 
                165                 170                 175     


Gln Asn Ile Phe Thr Ala Ala Lys Leu Val Ile Val Ala Ile Ile Ile 
            180                 185                 190         


Ile Ser Gly Leu Val Leu Leu Ala Gln Gly Asn Thr Lys Asn Phe Asp 
        195                 200                 205             


Asn Ser Phe Glu Gly Ala Gln Leu Ser Val Gly Ala Ile Ser Leu Ala 
    210                 215                 220                 


Phe Tyr Asn Gly Leu Trp Ala Tyr Asp Gly Trp Asn Gln Leu Asn Tyr 
225                 230                 235                 240 


Ile Thr Glu Glu Leu Arg Asn Pro Tyr Arg Asn Leu Pro Leu Ala Ile 
                245                 250                 255     


Ile Ile Gly Ile Pro Leu Val Thr Ala Cys Tyr Ile Leu Met Asn Val 
            260                 265                 270         


Ser Tyr Phe Thr Val Met Thr Ala Thr Glu Leu Leu Gln Ser Gln Ala 
        275                 280                 285             


Val Ala Val Thr Phe Gly Asp Arg Val Leu Tyr Pro Ala Ser Trp Ile 
    290                 295                 300                 


Val Pro Leu Phe Val Ala Phe Ser Thr Ile Gly Ala Ala Asn Gly Thr 
305                 310                 315                 320 


Cys Phe Thr Ala Gly Arg Leu Ile Tyr Val Ala Gly Arg Glu Gly His 
                325                 330                 335     


Met Leu Lys Val Leu Ser Tyr Ile Ser Val Arg Arg Leu Thr Pro Ala 
            340                 345                 350         


Pro Ala Ile Ile Phe Tyr Gly Ile Ile Ala Thr Ile Tyr Ile Ile Pro 
        355                 360                 365             


Gly Asp Ile Asn Ser Leu Val Asn Tyr Phe Ser Phe Ala Ala Trp Leu 
    370                 375                 380                 


Phe Tyr Gly Leu Thr Ile Leu Gly Leu Ile Val Met Arg Phe Thr Arg 
385                 390                 395                 400 


Lys Glu Leu Glu Arg Pro Ile Lys Val Pro Val Val Ile Pro Val Leu 
                405                 410                 415     


Met Thr Leu Ile Ser Val Phe Leu Val Leu Ala Pro Ile Ile Ser Lys 
            420                 425                 430         


Pro Thr Trp Glu Tyr Leu Tyr Cys Val Leu Phe Ile Leu Ser Gly Leu 
        435                 440                 445             


Leu Phe Tyr Phe Leu Phe Val His Tyr Lys Phe Gly Trp Ala Gln Lys 
    450                 455                 460                 


Ile Ser Lys Pro Ile Thr Met His Leu Gln Met Leu Met Glu Val Val 
465                 470                 475                 480 


Pro Pro Glu Glu Asp Pro Glu 
                485         


<210>  3905
<211>  696
<212>  PRT
<213>  Homo sapiens

<400>  3905

Met Lys Ala Pro Ile Pro His Leu Ile Leu Leu Tyr Ala Thr Phe Thr 
1               5                   10                  15      


Gln Ser Leu Lys Val Val Thr Lys Arg Gly Ser Ala Asp Gly Cys Thr 
            20                  25                  30          


Asp Trp Ser Ile Asp Ile Lys Lys Tyr Gln Val Leu Val Gly Glu Pro 
        35                  40                  45              


Val Arg Ile Lys Cys Ala Leu Phe Tyr Gly Tyr Ile Arg Thr Asn Tyr 
    50                  55                  60                  


Ser Leu Ala Gln Ser Ala Gly Leu Ser Leu Met Trp Tyr Lys Ser Ser 
65                  70                  75                  80  


Gly Pro Gly Asp Phe Glu Glu Pro Ile Ala Phe Asp Gly Ser Arg Met 
                85                  90                  95      


Ser Lys Glu Glu Asp Ser Ile Trp Phe Arg Pro Thr Leu Leu Gln Asp 
            100                 105                 110         


Ser Gly Leu Tyr Ala Cys Val Ile Arg Asn Ser Thr Tyr Cys Met Lys 
        115                 120                 125             


Val Ser Ile Ser Leu Thr Val Gly Glu Asn Asp Thr Gly Leu Cys Tyr 
    130                 135                 140                 


Asn Ser Lys Met Lys Tyr Phe Glu Lys Ala Glu Leu Ser Lys Ser Lys 
145                 150                 155                 160 


Glu Ile Ser Cys Arg Asp Ile Glu Asp Phe Leu Leu Pro Thr Arg Glu 
                165                 170                 175     


Pro Glu Ile Leu Trp Tyr Lys Glu Cys Arg Thr Lys Thr Trp Arg Pro 
            180                 185                 190         


Ser Ile Val Phe Lys Arg Asp Thr Leu Leu Ile Arg Glu Val Arg Glu 
        195                 200                 205             


Asp Asp Ile Gly Asn Tyr Thr Cys Glu Leu Lys Tyr Gly Gly Phe Val 
    210                 215                 220                 


Val Arg Arg Thr Thr Glu Leu Thr Val Thr Ala Pro Leu Thr Asp Lys 
225                 230                 235                 240 


Pro Pro Lys Leu Leu Tyr Pro Met Glu Ser Lys Leu Thr Ile Gln Glu 
                245                 250                 255     


Thr Gln Leu Gly Asp Ser Ala Asn Leu Thr Cys Arg Ala Phe Phe Gly 
            260                 265                 270         


Tyr Ser Gly Asp Val Ser Pro Leu Ile Tyr Trp Met Lys Gly Glu Lys 
        275                 280                 285             


Phe Ile Glu Asp Leu Asp Glu Asn Arg Val Trp Glu Ser Asp Ile Arg 
    290                 295                 300                 


Ile Leu Lys Glu His Leu Gly Glu Gln Glu Val Ser Ile Ser Leu Ile 
305                 310                 315                 320 


Val Asp Ser Val Glu Glu Gly Asp Leu Gly Asn Tyr Ser Cys Tyr Val 
                325                 330                 335     


Glu Asn Gly Asn Gly Arg Arg His Ala Ser Val Leu Leu His Lys Arg 
            340                 345                 350         


Glu Leu Met Tyr Thr Val Glu Leu Ala Gly Gly Leu Gly Ala Ile Leu 
        355                 360                 365             


Leu Leu Leu Val Cys Leu Val Thr Ile Tyr Lys Cys Tyr Lys Ile Glu 
    370                 375                 380                 


Ile Met Leu Phe Tyr Arg Asn His Phe Gly Ala Glu Glu Leu Asp Gly 
385                 390                 395                 400 


Asp Asn Lys Asp Tyr Asp Ala Tyr Leu Ser Tyr Thr Lys Val Asp Pro 
                405                 410                 415     


Asp Gln Trp Asn Gln Glu Thr Gly Glu Glu Glu Arg Phe Ala Leu Glu 
            420                 425                 430         


Ile Leu Pro Asp Met Leu Glu Lys His Tyr Gly Tyr Lys Leu Phe Ile 
        435                 440                 445             


Pro Asp Arg Asp Leu Ile Pro Thr Gly Thr Tyr Ile Glu Asp Val Ala 
    450                 455                 460                 


Arg Cys Val Asp Gln Ser Lys Arg Leu Ile Ile Val Met Thr Pro Asn 
465                 470                 475                 480 


Tyr Val Val Arg Arg Gly Trp Ser Ile Phe Glu Leu Glu Thr Arg Leu 
                485                 490                 495     


Arg Asn Met Leu Val Thr Gly Glu Ile Lys Val Ile Leu Ile Glu Cys 
            500                 505                 510         


Ser Glu Leu Arg Gly Ile Met Asn Tyr Gln Glu Val Glu Ala Leu Lys 
        515                 520                 525             


His Thr Ile Lys Leu Leu Thr Val Ile Lys Trp His Gly Pro Lys Cys 
    530                 535                 540                 


Asn Lys Leu Asn Ser Lys Phe Trp Lys Arg Leu Gln Tyr Glu Met Pro 
545                 550                 555                 560 


Phe Lys Arg Ile Glu Pro Ile Thr His Glu Gln Ala Leu Asp Val Ser 
                565                 570                 575     


Glu Gln Gly Pro Phe Gly Glu Leu Gln Thr Val Ser Ala Ile Ser Met 
            580                 585                 590         


Ala Ala Ala Thr Ser Thr Ala Leu Ala Thr Ala His Pro Asp Leu Arg 
        595                 600                 605             


Ser Thr Phe His Asn Thr Tyr His Ser Gln Met Arg Gln Lys His Tyr 
    610                 615                 620                 


Tyr Arg Ser Tyr Glu Tyr Asp Val Pro Pro Thr Gly Thr Leu Pro Leu 
625                 630                 635                 640 


Thr Ser Ile Gly Asn Gln His Thr Tyr Cys Asn Ile Pro Met Thr Leu 
                645                 650                 655     


Ile Asn Gly Gln Arg Pro Gln Thr Lys Ser Ser Arg Glu Gln Asn Pro 
            660                 665                 670         


Asp Glu Ala His Thr Asn Ser Ala Ile Leu Pro Leu Leu Pro Arg Glu 
        675                 680                 685             


Thr Ser Ile Ser Ser Val Ile Trp 
    690                 695     


<210>  3906
<211>  548
<212>  PRT
<213>  Homo sapiens

<400>  3906

Met Arg Leu Arg Asn Gly Thr Phe Leu Thr Leu Leu Leu Phe Cys Leu 
1               5                   10                  15      


Cys Ala Phe Leu Ser Leu Ser Trp Tyr Ala Ala Leu Ser Gly Gln Lys 
            20                  25                  30          


Gly Asp Val Val Asp Val Tyr Gln Arg Glu Phe Leu Ala Leu Arg Asp 
        35                  40                  45              


Arg Leu His Ala Ala Glu Gln Glu Ser Leu Lys Arg Ser Lys Glu Leu 
    50                  55                  60                  


Asn Leu Val Leu Asp Glu Ile Lys Arg Ala Val Ser Glu Arg Gln Ala 
65                  70                  75                  80  


Leu Arg Asp Gly Asp Gly Asn Arg Thr Trp Gly Arg Leu Thr Glu Asp 
                85                  90                  95      


Pro Arg Leu Lys Pro Trp Asn Gly Ser His Arg His Val Leu His Leu 
            100                 105                 110         


Pro Thr Val Phe His His Leu Pro His Leu Leu Ala Lys Glu Ser Ser 
        115                 120                 125             


Leu Gln Pro Ala Val Arg Val Gly Gln Gly Arg Thr Gly Val Ser Val 
    130                 135                 140                 


Val Met Gly Ile Pro Ser Val Arg Arg Glu Val His Ser Tyr Leu Thr 
145                 150                 155                 160 


Asp Thr Leu His Ser Leu Ile Ser Glu Leu Ser Pro Gln Glu Lys Glu 
                165                 170                 175     


Asp Ser Val Ile Val Val Leu Ile Ala Glu Thr Asp Ser Gln Tyr Thr 
            180                 185                 190         


Ser Ala Val Thr Glu Asn Ile Lys Ala Leu Phe Pro Thr Glu Ile His 
        195                 200                 205             


Ser Gly Leu Leu Glu Val Ile Ser Pro Ser Pro His Phe Tyr Pro Asp 
    210                 215                 220                 


Phe Ser Arg Leu Arg Glu Ser Phe Gly Asp Pro Lys Glu Arg Val Arg 
225                 230                 235                 240 


Trp Arg Thr Lys Gln Asn Leu Asp Tyr Cys Phe Leu Met Met Tyr Ala 
                245                 250                 255     


Gln Ser Lys Gly Ile Tyr Tyr Val Gln Leu Glu Asp Asp Ile Val Ala 
            260                 265                 270         


Lys Pro Asn Tyr Leu Ser Thr Met Lys Asn Phe Ala Leu Gln Gln Pro 
        275                 280                 285             


Ser Glu Asp Trp Met Ile Leu Glu Phe Ser Gln Leu Gly Phe Ile Gly 
    290                 295                 300                 


Lys Met Phe Lys Ser Leu Asp Leu Ser Leu Ile Val Glu Phe Ile Leu 
305                 310                 315                 320 


Met Phe Tyr Arg Asp Lys Pro Ile Asp Trp Leu Leu Asp His Ile Leu 
                325                 330                 335     


Trp Val Lys Val Cys Asn Pro Glu Lys Asp Ala Lys His Cys Asp Arg 
            340                 345                 350         


Gln Lys Ala Asn Leu Arg Ile Arg Phe Lys Pro Ser Leu Phe Gln His 
        355                 360                 365             


Val Gly Thr His Ser Ser Leu Ala Gly Lys Ile Gln Lys Leu Lys Asp 
    370                 375                 380                 


Lys Asp Phe Gly Lys Gln Ala Leu Arg Lys Glu His Val Asn Pro Pro 
385                 390                 395                 400 


Ala Glu Val Ser Thr Ser Leu Lys Thr Tyr Gln His Phe Thr Leu Glu 
                405                 410                 415     


Lys Ala Tyr Leu Arg Glu Asp Phe Phe Trp Ala Phe Thr Pro Ala Ala 
            420                 425                 430         


Gly Asp Phe Ile Arg Phe Arg Phe Phe Gln Pro Leu Arg Leu Glu Arg 
        435                 440                 445             


Phe Phe Phe Arg Ser Gly Asn Ile Glu His Pro Glu Asp Lys Leu Phe 
    450                 455                 460                 


Asn Thr Ser Val Glu Val Leu Pro Phe Asp Asn Pro Gln Ser Asp Lys 
465                 470                 475                 480 


Glu Ala Leu Gln Glu Gly Arg Thr Ala Thr Leu Arg Tyr Pro Arg Ser 
                485                 490                 495     


Pro Asp Gly Tyr Leu Gln Ile Gly Ser Phe Tyr Lys Gly Val Ala Glu 
            500                 505                 510         


Gly Glu Val Asp Pro Ala Phe Gly Pro Leu Glu Ala Leu Arg Leu Ser 
        515                 520                 525             


Ile Gln Thr Asp Ser Pro Val Trp Val Ile Leu Ser Glu Ile Phe Leu 
    530                 535                 540                 


Lys Lys Ala Asp 
545             


<210>  3907
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  3907

Met Lys Phe Leu Ala Val Leu Leu Ala Ala Gly Met Leu Ala Phe Leu 
1               5                   10                  15      


Gly Ala Val Ile Cys Ile Ile Ala Ser Val Pro Leu Ala Ala Ser Pro 
            20                  25                  30          


Ala Arg Ala Leu Pro Gly Gly Ala Asp Asn Ala Ser Val Ala Ser Gly 
        35                  40                  45              


Ala Ala Ala Ser Pro Gly Pro Gln Arg Ser Leu Ser Ala Leu His Gly 
    50                  55                  60                  


Ala Gly Gly Ser Ala Gly Pro Pro Ala Leu Pro Gly Ala Pro Ala Ala 
65                  70                  75                  80  


Ser Ala His Pro Leu Pro Pro Gly Pro Leu Phe Ser Arg Phe Leu Cys 
                85                  90                  95      


Thr Pro Leu Ala Ala Ala Cys Pro Ser Gly Ala Gln Gln Gly Asp Ala 
            100                 105                 110         


Ala Gly Ala Ala Pro Gly Glu Arg Glu Glu Leu Leu Leu Leu Gln Ser 
        115                 120                 125             


Thr Ala Glu Gln Leu Arg Gln Thr Ala Leu Gln Gln Glu Ala Arg Ile 
    130                 135                 140                 


Arg Ala Asp Gln Asp Thr Ile Arg Glu Leu Thr Gly Lys Leu Gly Arg 
145                 150                 155                 160 


Cys Glu Ser Gly Leu Pro Arg Gly Leu Gln Gly Ala Gly Pro Arg Arg 
                165                 170                 175     


Asp Thr Met Ala Asp Gly Pro Trp Asp Ser Pro Ala Leu Ile Leu Glu 
            180                 185                 190         


Leu Glu Asp Ala Val Arg Ala Leu Arg Asp Arg Ile Asp Arg Leu Glu 
        195                 200                 205             


Gln Glu Leu Pro Ala Arg Val Asn Leu Ser Ala Ala Pro Ala Pro Val 
    210                 215                 220                 


Ser Ala Val Pro Thr Gly Leu His Ser Lys Met Asp Gln Leu Glu Gly 
225                 230                 235                 240 


Gln Leu Leu Ala Gln Val Leu Ala Leu Glu Lys Glu Arg Val Ala Leu 
                245                 250                 255     


Ser His Ser Ser Arg Arg Gln Arg Gln Glu Val Glu Lys Glu Leu Asp 
            260                 265                 270         


Val Leu Gln Gly Arg Val Ala Glu Leu Glu His Gly Ser Ser Ala Tyr 
        275                 280                 285             


Ser Pro Pro Asp Ala Phe Lys Ile Ser Ile Pro Ile Arg Asn Asn Tyr 
    290                 295                 300                 


Met Tyr Ala Arg Val Arg Lys Ala Leu Pro Glu Leu Tyr Ala Phe Thr 
305                 310                 315                 320 


Ala Cys Met Trp Leu Arg Ser Arg Ser Ser Gly Thr Gly Gln Gly Thr 
                325                 330                 335     


Pro Phe Ser Tyr Ser Val Pro Gly Gln Ala Asn Glu Ile Val Leu Leu 
            340                 345                 350         


Glu Ala Gly His Glu Pro Met Glu Leu Leu Ile Asn Asp Lys Val Ala 
        355                 360                 365             


Gln Leu Pro Leu Ser Leu Lys Asp Asn Gly Trp His His Ile Cys Ile 
    370                 375                 380                 


Ala Trp Thr Thr Arg Asp Gly Leu Trp Ser Ala Tyr Gln Asp Gly Glu 
385                 390                 395                 400 


Leu Gln Gly Ser Gly Glu Asn Leu Ala Ala Trp His Pro Ile Lys Pro 
                405                 410                 415     


His Gly Ile Leu Ile Leu Gly Gln Glu Gln Asp Thr Leu Gly Gly Arg 
            420                 425                 430         


Phe Asp Ala Thr Gln Ala Phe Val Gly Asp Ile Ala Gln Phe Asn Leu 
        435                 440                 445             


Trp Asp His Ala Leu Thr Pro Ala Gln Val Leu Gly Ile Ala Asn Cys 
    450                 455                 460                 


Thr Ala Pro Leu Leu Gly Asn Val Leu Pro Trp Glu Asp Lys Leu Val 
465                 470                 475                 480 


Glu Ala Phe Gly Gly Ala Thr Lys Ala Ala Phe Asp Val Cys Lys Gly 
                485                 490                 495     


Arg Ala Lys Ala 
            500 


<210>  3908
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  3908

Met Ala Ile Arg Lys Lys Ser Thr Lys Ser Pro Pro Val Leu Ser His 
1               5                   10                  15      


Glu Phe Val Leu Gln Asn His Ala Asp Ile Val Ser Cys Val Ala Met 
            20                  25                  30          


Val Phe Leu Leu Gly Leu Met Phe Glu Ile Thr Ala Lys Ala Ser Ile 
        35                  40                  45              


Ile Phe Val Thr Leu Gln Tyr Asn Val Thr Leu Pro Ala Thr Glu Glu 
    50                  55                  60                  


Gln Ala Thr Glu Ser Val Ser Leu Tyr Tyr Tyr Gly Ile Lys Asp Leu 
65                  70                  75                  80  


Ala Thr Val Phe Phe Tyr Met Leu Val Ala Ile Ile Ile His Ala Val 
                85                  90                  95      


Ile Gln Glu Tyr Met Leu Asp Lys Ile Asn Arg Arg Met His Phe Ser 
            100                 105                 110         


Lys Thr Lys His Ser Lys Phe Asn Glu Ser Gly Gln Leu Ser Ala Phe 
        115                 120                 125             


Tyr Leu Phe Ala Cys Val Trp Gly Thr Phe Ile Leu Ile Ser Glu Asn 
    130                 135                 140                 


Tyr Ile Ser Asp Pro Thr Ile Leu Trp Arg Ala Tyr Pro His Asn Leu 
145                 150                 155                 160 


Met Thr Phe Gln Met Lys Phe Phe Tyr Ile Ser Gln Leu Ala Tyr Trp 
                165                 170                 175     


Leu His Ala Phe Pro Glu Leu Tyr Phe Gln Lys Thr Lys Lys Glu Asp 
            180                 185                 190         


Ile Pro Arg Gln Leu Val Tyr Ile Gly Leu Tyr Leu Phe His Ile Ala 
        195                 200                 205             


Gly Ala Tyr Leu Leu Asn Leu Asn His Leu Gly Leu Val Leu Leu Val 
    210                 215                 220                 


Leu His Tyr Phe Val Glu Phe Leu Phe His Ile Ser Arg Leu Phe Tyr 
225                 230                 235                 240 


Phe Ser Asn Glu Lys Tyr Gln Lys Gly Phe Ser Leu Trp Ala Val Leu 
                245                 250                 255     


Phe Val Leu Gly Arg Leu Leu Thr Leu Ile Leu Ser Val Leu Thr Val 
            260                 265                 270         


Gly Phe Gly Leu Ala Arg Ala Glu Asn Gln Lys Leu Asp Phe Ser Thr 
        275                 280                 285             


Gly Asn Phe Asn Val Leu Ala Val Arg Ile Ala Val Leu Ala Ser Ile 
    290                 295                 300                 


Cys Val Thr Gln Ala Phe Met Met Trp Lys Phe Ile Asn Phe Gln Leu 
305                 310                 315                 320 


Arg Arg Trp Arg Glu His Ser Ala Phe Gln Ala Pro Ala Val Lys Lys 
                325                 330                 335     


Lys Pro Thr Val Thr Lys Gly Arg Ser Ser Lys Lys Gly Thr Glu Asn 
            340                 345                 350         


Gly Val Asn Gly Thr Leu Thr Ser Asn Val Ala Asp Ser Pro Arg Asn 
        355                 360                 365             


Lys Lys Glu Lys Ser Ser 
    370                 


<210>  3909
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  3909

Met Leu Ser Leu Asp Phe Leu Asp Asp Val Arg Arg Met Asn Lys Arg 
1               5                   10                  15      


Gln Leu Tyr Tyr Gln Val Leu Asn Phe Gly Met Ile Val Ser Ser Ala 
            20                  25                  30          


Leu Met Ile Trp Lys Gly Leu Met Val Ile Thr Gly Ser Glu Ser Pro 
        35                  40                  45              


Ile Val Val Val Leu Ser Gly Ser Met Glu Pro Ala Phe His Arg Gly 
    50                  55                  60                  


Asp Leu Leu Phe Leu Thr Asn Arg Val Glu Asp Pro Ile Arg Val Gly 
65                  70                  75                  80  


Glu Ile Val Val Phe Arg Ile Glu Gly Arg Glu Ile Pro Ile Val His 
                85                  90                  95      


Arg Val Leu Lys Ile His Glu Lys Gln Asn Gly His Ile Lys Phe Leu 
            100                 105                 110         


Thr Lys Gly Asp Asn Asn Ala Val Asp Asp Arg Gly Leu Tyr Lys Gln 
        115                 120                 125             


Gly Gln His Trp Leu Glu Lys Lys Asp Val Val Gly Arg Ala Arg Gly 
    130                 135                 140                 


Phe Val Pro Tyr Ile Gly Ile Val Thr Ile Leu Met Asn Asp Tyr Pro 
145                 150                 155                 160 


Lys Phe Lys Tyr Ala Val Leu Phe Leu Leu Gly Leu Phe Val Leu Val 
                165                 170                 175     


His Arg Glu 
            


<210>  3910
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  3910

Met Asp Gln Val Met Gln Phe Val Glu Pro Ser Arg Gln Phe Val Lys 
1               5                   10                  15      


Asp Ser Ile Arg Leu Val Lys Arg Cys Thr Lys Pro Asp Arg Lys Glu 
            20                  25                  30          


Phe Gln Lys Ile Ala Met Ala Thr Ala Ile Gly Phe Ala Ile Met Gly 
        35                  40                  45              


Phe Ile Gly Phe Phe Val Lys Leu Ile His Ile Pro Ile Asn Asn Ile 
    50                  55                  60                  


Ile Val Gly Gly 
65              


<210>  3911
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  3911

Met Ala Glu Leu Pro Gly Pro Phe Leu Cys Gly Ala Leu Leu Gly Phe 
1               5                   10                  15      


Leu Cys Leu Ser Gly Leu Ala Val Glu Val Lys Val Pro Thr Glu Pro 
            20                  25                  30          


Leu Ser Thr Pro Leu Gly Lys Thr Ala Glu Leu Thr Cys Thr Tyr Ser 
        35                  40                  45              


Thr Ser Val Gly Asp Ser Phe Ala Leu Glu Trp Ser Phe Val Gln Pro 
    50                  55                  60                  


Gly Lys Pro Ile Ser Glu Ser His Pro Ile Leu Tyr Phe Thr Asn Gly 
65                  70                  75                  80  


His Leu Tyr Pro Thr Gly Ser Lys Ser Lys Arg Val Ser Leu Leu Gln 
                85                  90                  95      


Asn Pro Pro Thr Val Gly Val Ala Thr Leu Lys Leu Thr Asp Val His 
            100                 105                 110         


Pro Ser Asp Thr Gly Thr Tyr Leu Cys Gln Val Asn Asn Pro Pro Asp 
        115                 120                 125             


Phe Tyr Thr Asn Gly Leu Gly Leu Ile Asn Leu Thr Val Leu Val Pro 
    130                 135                 140                 


Pro Ser Asn Pro Leu Cys Ser Gln Ser Gly Gln Thr Ser Val Gly Gly 
145                 150                 155                 160 


Ser Thr Ala Leu Arg Cys Ser Ser Ser Glu Gly Ala Pro Lys Pro Val 
                165                 170                 175     


Tyr Asn Trp Val Arg Leu Gly Thr Phe Pro Thr Pro Ser Pro Gly Ser 
            180                 185                 190         


Met Val Gln Asp Glu Val Ser Gly Gln Leu Ile Leu Thr Asn Leu Ser 
        195                 200                 205             


Leu Thr Ser Ser Gly Thr Tyr Arg Cys Val Ala Thr Asn Gln Met Gly 
    210                 215                 220                 


Ser Ala Ser Cys Glu Leu Thr Leu Ser Val Thr Glu Pro Ser Gln Gly 
225                 230                 235                 240 


Arg Val Ala Gly Ala Leu Ile Gly Val Leu Leu Gly Val Leu Leu Leu 
                245                 250                 255     


Ser Val Ala Ala Phe Cys Leu Val Arg Phe Gln Lys Glu Arg Gly Lys 
            260                 265                 270         


Lys Pro Lys Glu Thr Tyr Gly Gly Ser Asp Leu Arg Glu Asp Ala Ile 
        275                 280                 285             


Ala Pro Gly Ile Ser Glu His Thr Cys Met Arg Ala Asp Ser Ser Lys 
    290                 295                 300                 


Gly Phe Leu Glu Arg Pro Ser Ser Ala Ser Thr Val Thr Thr Thr Lys 
305                 310                 315                 320 


Ser Lys Leu Pro Met Val Val 
                325         


<210>  3912
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  3912

Met Ser Gly Phe Leu Glu Gly Leu Arg Cys Ser Glu Cys Ile Asp Trp 
1               5                   10                  15      


Gly Glu Lys Arg Asn Thr Ile Ala Ser Ile Ala Ala Gly Val Leu Phe 
            20                  25                  30          


Phe Thr Gly Trp Trp Ile Ile Ile Asp Ala Ala Val Ile Tyr Pro Thr 
        35                  40                  45              


Met Lys Asp Phe Asn His Ser Tyr His Ala Cys Gly Val Ile Ala Thr 
    50                  55                  60                  


Ile Ala Phe Leu Met Ile Asn Ala Val Ser Asn Gly Gln Val Arg Gly 
65                  70                  75                  80  


Asp Ser Tyr Ser Glu Gly Cys Leu Gly Gln Thr Gly Ala Arg Ile Trp 
                85                  90                  95      


Leu Phe Val Gly Phe Met Leu Ala Phe Gly Ser Leu Ile Ala Ser Met 
            100                 105                 110         


Trp Ile Leu Phe Gly Gly Tyr Val Ala Lys Glu Lys Asp Ile Val Tyr 
        115                 120                 125             


Pro Gly Ile Ala Val Phe Phe Gln Asn Ala Phe Ile Phe Phe Gly Gly 
    130                 135                 140                 


Leu Val Phe Lys Phe Gly Arg Thr Glu Asp Leu Trp Gln 
145                 150                 155         


<210>  3913
<211>  911
<212>  PRT
<213>  Homo sapiens

<400>  3913

Met Ala Ala Ala Ala Ala Ser Ala Pro Gln Gln Leu Ser Asp Glu Glu 
1               5                   10                  15      


Leu Phe Ser Gln Leu Arg Arg Tyr Gly Leu Ser Pro Gly Pro Val Thr 
            20                  25                  30          


Glu Ser Thr Arg Pro Val Tyr Leu Lys Lys Leu Lys Lys Leu Arg Glu 
        35                  40                  45              


Glu Glu Gln Gln Gln His Arg Ser Gly Gly Arg Gly Asn Lys Thr Arg 
    50                  55                  60                  


Asn Ser Asn Asn Asn Asn Thr Ala Ala Ala Thr Val Ala Ala Ala Gly 
65                  70                  75                  80  


Pro Ala Ala Ala Ala Ala Ala Gly Met Gly Val Arg Pro Val Ser Gly 
                85                  90                  95      


Asp Leu Ser Tyr Leu Arg Thr Pro Gly Gly Leu Cys Arg Ile Ser Ala 
            100                 105                 110         


Ser Gly Pro Glu Ser Leu Leu Gly Gly Pro Gly Gly Ala Ser Ala Ala 
        115                 120                 125             


Pro Ala Ala Gly Ser Lys Val Leu Leu Gly Phe Ser Ser Asp Glu Ser 
    130                 135                 140                 


Asp Val Glu Ala Ser Pro Arg Asp Gln Ala Gly Gly Gly Gly Arg Lys 
145                 150                 155                 160 


Asp Arg Ala Ser Leu Gln Tyr Arg Gly Leu Lys Ala Pro Pro Ala Pro 
                165                 170                 175     


Leu Ala Ala Ser Glu Val Thr Asn Ser Asn Ser Ala Glu Arg Arg Lys 
            180                 185                 190         


Pro His Ser Trp Trp Gly Ala Arg Arg Pro Ala Gly Pro Glu Leu Gln 
        195                 200                 205             


Thr Pro Pro Gly Lys Asp Gly Ala Val Glu Asp Glu Glu Gly Glu Gly 
    210                 215                 220                 


Glu Asp Gly Glu Glu Arg Asp Pro Glu Thr Glu Glu Pro Leu Trp Ala 
225                 230                 235                 240 


Ser Arg Thr Val Asn Gly Ser Arg Leu Val Pro Tyr Ser Cys Arg Glu 
                245                 250                 255     


Asn Tyr Ser Asp Ser Glu Glu Glu Asp Asp Asp Asp Val Ala Ser Ser 
            260                 265                 270         


Arg Gln Val Leu Lys Asp Asp Ser Leu Ser Arg His Arg Pro Arg Arg 
        275                 280                 285             


Thr His Ser Lys Pro Leu Pro Pro Leu Thr Ala Lys Ser Ala Gly Gly 
    290                 295                 300                 


Arg Leu Glu Thr Ser Val Gln Gly Gly Gly Gly Leu Ala Met Asn Asp 
305                 310                 315                 320 


Arg Ala Ala Ala Ala Gly Ser Leu Asp Arg Ser Arg Asn Leu Glu Glu 
                325                 330                 335     


Ala Ala Ala Ala Glu Gln Gly Gly Gly Cys Asp Gln Val Asp Ser Ser 
            340                 345                 350         


Pro Val Pro Arg Tyr Arg Val Asn Ala Lys Lys Leu Thr Pro Leu Leu 
        355                 360                 365             


Pro Pro Pro Leu Thr Asp Met Asp Ser Thr Leu Asp Ser Ser Thr Gly 
    370                 375                 380                 


Ser Leu Leu Lys Thr Asn Asn His Ile Gly Gly Gly Ala Phe Ser Val 
385                 390                 395                 400 


Asp Ser Pro Arg Ile Tyr Ser Asn Ser Leu Pro Pro Ser Ala Ala Val 
                405                 410                 415     


Ala Ala Ser Ser Ser Leu Arg Ile Asn His Ala Asn His Thr Gly Ser 
            420                 425                 430         


Asn His Thr Tyr Leu Lys Asn Thr Tyr Asn Lys Pro Lys Leu Ser Glu 
        435                 440                 445             


Pro Glu Glu Glu Leu Leu Gln Gln Phe Lys Arg Glu Glu Val Ser Pro 
    450                 455                 460                 


Thr Gly Ser Phe Ser Ala His Tyr Leu Ser Met Phe Leu Leu Thr Ala 
465                 470                 475                 480 


Ala Cys Leu Phe Phe Leu Ile Leu Gly Leu Thr Tyr Leu Gly Met Arg 
                485                 490                 495     


Gly Thr Gly Val Ser Glu Asp Gly Glu Leu Ser Ile Glu Asn Pro Phe 
            500                 505                 510         


Gly Glu Thr Phe Gly Lys Ile Gln Glu Ser Glu Lys Thr Leu Met Met 
        515                 520                 525             


Asn Thr Leu Tyr Lys Leu His Asp Arg Leu Ala Gln Leu Ala Gly Asp 
    530                 535                 540                 


His Glu Cys Gly Ser Ser Ser Gln Arg Thr Leu Ser Val Gln Glu Ala 
545                 550                 555                 560 


Ala Ala Tyr Leu Lys Asp Leu Gly Pro Glu Tyr Glu Gly Ile Phe Asn 
                565                 570                 575     


Thr Ser Leu Gln Trp Ile Leu Glu Asn Gly Lys Asp Val Gly Ile Arg 
            580                 585                 590         


Cys Val Gly Phe Gly Pro Glu Glu Glu Leu Thr Asn Ile Thr Asp Val 
        595                 600                 605             


Gln Phe Leu Gln Ser Thr Arg Pro Leu Met Ser Phe Trp Cys Arg Phe 
    610                 615                 620                 


Arg Arg Ala Phe Val Thr Val Thr His Arg Leu Leu Leu Leu Cys Leu 
625                 630                 635                 640 


Gly Val Val Met Val Cys Val Val Leu Arg Tyr Met Lys Tyr Arg Trp 
                645                 650                 655     


Thr Lys Glu Glu Glu Glu Thr Arg Gln Met Tyr Asp Met Val Val Lys 
            660                 665                 670         


Ile Ile Asp Val Leu Arg Ser His Asn Glu Ala Cys Gln Glu Asn Lys 
        675                 680                 685             


Asp Leu Gln Pro Tyr Met Pro Ile Pro His Val Arg Asp Ser Leu Ile 
    690                 695                 700                 


Gln Pro His Asp Arg Lys Lys Met Lys Lys Val Trp Asp Arg Ala Val 
705                 710                 715                 720 


Asp Phe Leu Ala Ala Asn Glu Ser Arg Val Arg Thr Glu Thr Arg Arg 
                725                 730                 735     


Ile Gly Gly Ala Asp Phe Leu Val Trp Arg Trp Ile Gln Pro Ser Ala 
            740                 745                 750         


Ser Cys Asp Lys Ile Leu Val Ile Pro Ser Lys Val Trp Gln Gly Gln 
        755                 760                 765             


Ala Phe His Leu Asp Arg Arg Asn Ser Pro Pro Asn Ser Leu Thr Pro 
    770                 775                 780                 


Cys Leu Lys Ile Arg Asn Met Phe Asp Pro Val Met Glu Ile Gly Asp 
785                 790                 795                 800 


Gln Trp His Leu Ala Ile Gln Glu Ala Ile Leu Glu Lys Cys Ser Asp 
                805                 810                 815     


Asn Asp Gly Ile Val His Ile Ala Val Asp Lys Asn Ser Arg Glu Gly 
            820                 825                 830         


Cys Val Tyr Val Lys Cys Leu Ser Pro Glu Tyr Ala Gly Lys Ala Phe 
        835                 840                 845             


Lys Ala Leu His Gly Ser Trp Phe Asp Gly Lys Leu Val Thr Val Lys 
    850                 855                 860                 


Tyr Leu Arg Leu Asp Arg Tyr His His Arg Phe Pro Gln Ala Leu Thr 
865                 870                 875                 880 


Ser Asn Thr Pro Leu Lys Pro Ser Asn Lys His Met Asn Ser Met Ser 
                885                 890                 895     


His Leu Arg Leu Arg Thr Gly Leu Thr Asn Ser Gln Gly Ser Ser 
            900                 905                 910     


<210>  3914
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  3914

Met Tyr Ser Gly Asn Arg Ser Gly Gly His Gly Tyr Trp Asp Gly Gly 
1               5                   10                  15      


Gly Ala Ala Gly Ala Glu Gly Pro Ala Pro Ala Gly Thr Leu Ser Pro 
            20                  25                  30          


Ala Pro Leu Phe Ser Pro Gly Thr Tyr Glu Arg Leu Ala Leu Leu Leu 
        35                  40                  45              


Gly Ser Ile Gly Leu Leu Gly Val Gly Asn Asn Leu Leu Val Leu Val 
    50                  55                  60                  


Leu Tyr Tyr Lys Phe Gln Arg Leu Arg Thr Pro Thr His Leu Leu Leu 
65                  70                  75                  80  


Val Asn Ile Ser Leu Ser Asp Leu Leu Val Ser Leu Phe Gly Val Thr 
                85                  90                  95      


Phe Thr Phe Val Ser Cys Leu Arg Asn Gly Trp Val Trp Asp Thr Val 
            100                 105                 110         


Gly Cys Val Trp Asp Gly Phe Ser Gly Ser Leu Phe Gly Ile Val Ser 
        115                 120                 125             


Ile Ala Thr Leu Thr Val Leu Ala Tyr Glu Arg Tyr Ile Arg Val Val 
    130                 135                 140                 


His Ala Arg Val Ile Asn Phe Ser Trp Ala Trp Arg Ala Ile Thr Tyr 
145                 150                 155                 160 


Ile Trp Leu Tyr Ser Leu Ala Trp Ala Gly Ala Pro Leu Leu Gly Trp 
                165                 170                 175     


Asn Arg Tyr Ile Leu Asp Val His Gly Leu Gly Cys Thr Val Asp Trp 
            180                 185                 190         


Lys Ser Lys Asp Ala Asn Asp Ser Ser Phe Val Leu Phe Leu Phe Leu 
        195                 200                 205             


Gly Cys Leu Val Val Pro Leu Gly Val Ile Ala His Cys Tyr Gly His 
    210                 215                 220                 


Ile Leu Tyr Ser Ile Arg Met Leu Arg Cys Val Glu Asp Leu Gln Thr 
225                 230                 235                 240 


Ile Gln Val Ile Lys Ile Leu Lys Tyr Glu Lys Lys Leu Ala Lys Met 
                245                 250                 255     


Cys Phe Leu Met Ile Phe Thr Phe Leu Val Cys Trp Met Pro Tyr Ile 
            260                 265                 270         


Val Ile Cys Phe Leu Val Val Asn Gly His Gly His Leu Val Thr Pro 
        275                 280                 285             


Thr Ile Ser Ile Val Ser Tyr Leu Phe Ala Lys Ser Asn Thr Val Tyr 
    290                 295                 300                 


Asn Pro Val Ile Tyr Val Phe Met Ile Arg Lys Phe Arg Arg Ser Leu 
305                 310                 315                 320 


Leu Gln Leu Leu Cys Leu Arg Leu Leu Arg Cys Gln Arg Pro Ala Lys 
                325                 330                 335     


Asp Leu Pro Ala Ala Gly Ser Glu Met Gln Ile Arg Pro Ile Val Met 
            340                 345                 350         


Ser Gln Lys Asp Gly Asp Arg Pro Lys Lys Lys Val Thr Phe Asn Ser 
        355                 360                 365             


Ser Ser Ile Ile Phe Ile Ile Thr Ser Asp Glu Ser Leu Ser Val Asp 
    370                 375                 380                 


Asp Ser Asp Lys Thr Asn Gly Ser Lys Val Asp Val Ile Gln Val Arg 
385                 390                 395                 400 


Pro Leu 
        


<210>  3915
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  3915

Met Val Arg Lys Pro Val Val Ser Thr Ile Ser Lys Gly Gly Tyr Leu 
1               5                   10                  15      


Gln Gly Asn Val Asn Gly Arg Leu Pro Ser Leu Gly Asn Lys Glu Pro 
            20                  25                  30          


Pro Gly Gln Glu Lys Val Gln Leu Lys Arg Lys Val Thr Leu Leu Arg 
        35                  40                  45              


Gly Val Ser Ile Ile Ile Gly Thr Ile Ile Gly Ala Gly Ile Phe Ile 
    50                  55                  60                  


Ser Pro Lys Gly Val Leu Gln Asn Thr Gly Ser Val Gly Met Ser Leu 
65                  70                  75                  80  


Thr Ile Trp Thr Val Cys Gly Val Leu Ser Leu Phe Gly Ala Leu Ser 
                85                  90                  95      


Tyr Ala Glu Leu Gly Thr Thr Ile Lys Lys Ser Gly Gly His Tyr Thr 
            100                 105                 110         


Tyr Ile Leu Glu Val Phe Gly Pro Leu Pro Ala Phe Val Arg Val Trp 
        115                 120                 125             


Val Glu Leu Leu Ile Ile Arg Pro Ala Ala Thr Ala Val Ile Ser Leu 
    130                 135                 140                 


Ala Phe Gly Arg Tyr Ile Leu Glu Pro Phe Phe Ile Gln Cys Glu Ile 
145                 150                 155                 160 


Pro Glu Leu Ala Ile Lys Leu Ile Thr Ala Val Gly Ile Thr Val Val 
                165                 170                 175     


Met Val Leu Asn Ser Met Ser Val Ser Trp Ser Ala Arg Ile Gln Ile 
            180                 185                 190         


Phe Leu Thr Phe Cys Lys Leu Thr Ala Ile Leu Ile Ile Ile Val Pro 
        195                 200                 205             


Gly Val Met Gln Leu Ile Lys Gly Gln Thr Gln Asn Phe Lys Asp Ala 
    210                 215                 220                 


Phe Ser Gly Arg Asp Ser Ser Ile Thr Arg Leu Pro Leu Ala Phe Tyr 
225                 230                 235                 240 


Tyr Gly Met Tyr Ala Tyr Ala Gly Trp Phe Tyr Leu Asn Phe Val Thr 
                245                 250                 255     


Glu Glu Val Glu Asn Pro Glu Lys Thr Ile Pro Leu Ala Ile Cys Ile 
            260                 265                 270         


Ser Met Ala Ile Val Thr Ile Gly Tyr Val Leu Thr Asn Val Ala Tyr 
        275                 280                 285             


Phe Thr Thr Ile Asn Ala Glu Glu Leu Leu Leu Ser Asn Ala Val Ala 
    290                 295                 300                 


Val Thr Phe Ser Glu Arg Leu Leu Gly Asn Phe Ser Leu Ala Val Pro 
305                 310                 315                 320 


Ile Phe Val Ala Leu Ser Cys Phe Gly Ser Met Asn Gly Gly Val Phe 
                325                 330                 335     


Ala Val Ser Arg Leu Phe Tyr Val Ala Ser Arg Glu Gly His Leu Pro 
            340                 345                 350         


Glu Ile Leu Ser Met Ile His Val Arg Lys His Thr Pro Leu Pro Ala 
        355                 360                 365             


Val Ile Val Leu His Pro Leu Thr Met Ile Met Leu Phe Ser Gly Asp 
    370                 375                 380                 


Leu Asp Ser Leu Leu Asn Phe Leu Ser Phe Ala Arg Trp Leu Phe Ile 
385                 390                 395                 400 


Gly Leu Ala Val Ala Gly Leu Ile Tyr Leu Arg Tyr Lys Cys Pro Asp 
                405                 410                 415     


Met His Arg Pro Phe Lys Val Pro Leu Phe Ile Pro Ala Leu Phe Ser 
            420                 425                 430         


Phe Thr Cys Leu Phe Met Val Ala Leu Ser Leu Tyr Ser Asp Pro Phe 
        435                 440                 445             


Ser Thr Gly Ile Gly Phe Val Ile Thr Leu Thr Gly Val Pro Ala Tyr 
    450                 455                 460                 


Tyr Leu Phe Ile Ile Trp Asp Lys Lys Pro Arg Trp Phe Arg Ile Met 
465                 470                 475                 480 


Ser Glu Lys Ile Thr Arg Thr Leu Gln Ile Ile Leu Glu Val Val Pro 
                485                 490                 495     


Glu Glu Asp Lys Leu 
            500     


<210>  3916
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  3916

Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln Cys Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu Leu Leu Leu Leu 
            20                  25                  30          


Phe Ser Ala Ala Ala Leu Ile Pro Thr Gly Asp Gly Gln Asn Leu Phe 
        35                  40                  45              


Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val Ala Thr Ile Ser Cys 
    50                  55                  60                  


Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln Leu Leu Asn Pro Asn 
65                  70                  75                  80  


Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro Leu Lys Asp Ser Arg 
                85                  90                  95      


Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys Val Ser Leu Thr 
            100                 105                 110         


Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe Cys Gln Leu Tyr Thr 
        115                 120                 125             


Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr Val Leu Val Pro Pro 
    130                 135                 140                 


Arg Asn Leu Met Ile Asp Ile Gln Lys Asp Thr Ala Val Glu Gly Glu 
145                 150                 155                 160 


Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala Thr Thr 
                165                 170                 175     


Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys Gly Lys Ser Glu Val 
            180                 185                 190         


Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln Leu Met Leu Lys 
        195                 200                 205             


Val His Lys Glu Asp Asp Gly Val Pro Val Ile Cys Gln Val Glu His 
    210                 215                 220                 


Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr Leu Glu Val Gln 
225                 230                 235                 240 


Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro Leu Gln Gly Leu 
                245                 250                 255     


Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu Ala Ile Gly Lys 
            260                 265                 270         


Pro Gln Pro Val Met Val Thr Trp Val Arg Val Asp Asp Glu Met Pro 
        275                 280                 285             


Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe Ile Asn Asn Leu Asn 
    290                 295                 300                 


Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser Asn Ile Val Gly 
305                 310                 315                 320 


Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr Asp Pro Pro Thr Thr 
                325                 330                 335     


Ile Pro Pro Pro Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr 
            340                 345                 350         


Thr Ile Leu Thr Ile Ile Thr Asp Ser Arg Ala Gly Glu Glu Gly Ser 
        355                 360                 365             


Ile Arg Ala Val Asp His Ala Val Ile Gly Gly Val Val Ala Val Val 
    370                 375                 380                 


Val Phe Ala Met Leu Cys Leu Leu Ile Ile Leu Gly Arg Tyr Phe Ala 
385                 390                 395                 400 


Arg His Lys Gly Thr Tyr Phe Thr His Glu Ala Lys Gly Ala Asp Asp 
                405                 410                 415     


Ala Ala Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu Gly Gly Gln Asn 
            420                 425                 430         


Asn Ser Glu Glu Lys Lys Glu Tyr Phe Ile 
        435                 440         


<210>  3917
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  3917

Met Arg Arg Pro Arg Gln Gly Gly Gly Gly Ala Gly Gly Ser Ala Ala 
1               5                   10                  15      


Ala Arg Ala Arg Ala Gly Gly Leu Gly Gly Gly Ser Val Pro Ala Arg 
            20                  25                  30          


Ala Arg Gly Ala Pro Ala Ala Ala Arg Ala Ala Trp Leu Arg Asp Leu 
        35                  40                  45              


Cys Ala Arg Met Ala Arg Pro Pro Arg Gln His Pro Gly Val Trp Ala 
    50                  55                  60                  


Ser Leu Leu Leu Leu Leu Leu Thr Gly Pro Ala Ala Cys Ala Ala Ser 
65                  70                  75                  80  


Pro Ala Asp Asp Gly Ala Gly Pro Gly Gly Arg Gly Pro Arg Gly Arg 
                85                  90                  95      


Ala Arg Gly Asp Thr Gly Ala Asp Glu Ala Val Pro Arg His Asp Ser 
            100                 105                 110         


Ser Tyr Gly Thr Phe Ala Gly Glu Phe Tyr Asp Leu Arg Tyr Leu Ser 
        115                 120                 125             


Glu Glu Gly Tyr Pro Phe Pro Thr Ala Pro Pro Val Asp Pro Phe Ala 
    130                 135                 140                 


Lys Ile Lys Val Asp Asp Cys Gly Lys Thr Lys Gly Cys Phe Arg Tyr 
145                 150                 155                 160 


Gly Lys Pro Gly Cys Asn Ala Glu Thr Cys Asp Tyr Phe Leu Ser Tyr 
                165                 170                 175     


Arg Met Ile Gly Ala Asp Val Glu Phe Glu Leu Ser Ala Asp Thr Asp 
            180                 185                 190         


Gly Trp Val Ala Val Gly Phe Ser Ser Asp Lys Lys Met Gly Gly Asp 
        195                 200                 205             


Asp Val Met Ala Cys Val His Asp Asp Asn Gly Arg Val Arg Ile Gln 
    210                 215                 220                 


His Phe Tyr Asn Val Gly Gln Trp Ala Lys Glu Ile Gln Arg Asn Pro 
225                 230                 235                 240 


Ala Arg Asp Glu Glu Gly Val Phe Glu Asn Asn Arg Val Thr Cys Arg 
                245                 250                 255     


Phe Lys Arg Pro Val Asn Val Pro Arg Asp Glu Thr Ile Val Asp Leu 
            260                 265                 270         


His Leu Ser Trp Tyr Tyr Leu Phe Ala Trp Gly Pro Ala Ile Gln Gly 
        275                 280                 285             


Ser Ile Thr Arg His Asp Ile Asp Ser Pro Pro Ala Ser Glu Arg Val 
    290                 295                 300                 


Val Ser Ile Tyr Lys Tyr Glu Asp Ile Phe Met Pro Ser Ala Ala Tyr 
305                 310                 315                 320 


Gln Thr Phe Ser Ser Pro Phe Cys Leu Leu Leu Ile Val Ala Leu Thr 
                325                 330                 335     


Phe Tyr Leu Leu Met Gly Thr Pro 
            340                 


<210>  3918
<211>  866
<212>  PRT
<213>  Homo sapiens

<400>  3918

Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro Gly Pro Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro Gly Gly Ala Ser 
            20                  25                  30          


Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly Leu 
        35                  40                  45              


Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His 
    50                  55                  60                  


Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu 
65                  70                  75                  80  


His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile 
                85                  90                  95      


Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala 
            100                 105                 110         


Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg 
        115                 120                 125             


Phe Glu Phe Leu Ser Lys Leu Arg His His His Arg Arg Trp Arg Phe 
    130                 135                 140                 


Thr Phe Ser His Phe Val Val Asp Pro Asp Gln Glu Tyr Glu Val Thr 
145                 150                 155                 160 


Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln 
                165                 170                 175     


Ser Lys Asn Phe Leu Val Pro Asp Cys Glu His Ala Arg Met Lys Val 
            180                 185                 190         


Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile Thr 
        195                 200                 205             


Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu Trp 
    210                 215                 220                 


Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His Met 
225                 230                 235                 240 


Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro Arg 
                245                 250                 255     


Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg Asn 
            260                 265                 270         


Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe Ser 
        275                 280                 285             


Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala Thr Val Ser Cys Pro 
    290                 295                 300                 


Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Asp Tyr Met Pro Leu Trp 
305                 310                 315                 320 


Val Tyr Trp Phe Ile Thr Gly Ile Ser Ile Leu Leu Val Gly Ser Val 
                325                 330                 335     


Ile Leu Leu Ile Val Cys Met Thr Trp Arg Leu Ala Gly Pro Gly Ser 
            340                 345                 350         


Glu Lys Tyr Ser Asp Asp Thr Lys Tyr Thr Asp Gly Leu Pro Ala Ala 
        355                 360                 365             


Asp Leu Ile Pro Pro Pro Leu Lys Pro Arg Lys Val Trp Ile Ile Tyr 
    370                 375                 380                 


Ser Ala Asp His Pro Leu Tyr Val Asp Val Val Leu Lys Phe Ala Gln 
385                 390                 395                 400 


Phe Leu Leu Thr Ala Cys Gly Thr Glu Val Ala Leu Asp Leu Leu Glu 
                405                 410                 415     


Glu Gln Ala Ile Ser Glu Ala Gly Val Met Thr Trp Val Gly Arg Gln 
            420                 425                 430         


Lys Gln Glu Met Val Glu Ser Asn Ser Lys Ile Ile Val Leu Cys Ser 
        435                 440                 445             


Arg Gly Thr Arg Ala Lys Trp Gln Ala Leu Leu Gly Arg Gly Ala Pro 
    450                 455                 460                 


Val Arg Leu Arg Cys Asp His Gly Lys Pro Val Gly Asp Leu Phe Thr 
465                 470                 475                 480 


Ala Ala Met Asn Met Ile Leu Pro Asp Phe Lys Arg Pro Ala Cys Phe 
                485                 490                 495     


Gly Thr Tyr Val Val Cys Tyr Phe Ser Glu Val Ser Cys Asp Gly Asp 
            500                 505                 510         


Val Pro Asp Leu Phe Gly Ala Ala Pro Arg Tyr Pro Leu Met Asp Arg 
        515                 520                 525             


Phe Glu Glu Val Tyr Phe Arg Ile Gln Asp Leu Glu Met Phe Gln Pro 
    530                 535                 540                 


Gly Arg Met His Arg Val Gly Glu Leu Ser Gly Asp Asn Tyr Leu Arg 
545                 550                 555                 560 


Ser Pro Gly Gly Arg Gln Leu Arg Ala Ala Leu Asp Arg Phe Arg Asp 
                565                 570                 575     


Trp Gln Val Arg Cys Pro Asp Trp Phe Glu Cys Glu Asn Leu Tyr Ser 
            580                 585                 590         


Ala Asp Asp Gln Asp Ala Pro Ser Leu Asp Glu Glu Val Phe Glu Glu 
        595                 600                 605             


Pro Leu Leu Pro Pro Gly Thr Gly Ile Val Lys Arg Ala Pro Leu Val 
    610                 615                 620                 


Arg Glu Pro Gly Ser Gln Ala Cys Leu Ala Ile Asp Pro Leu Val Gly 
625                 630                 635                 640 


Glu Glu Gly Gly Ala Ala Val Ala Lys Leu Glu Pro His Leu Gln Pro 
                645                 650                 655     


Arg Gly Gln Pro Ala Pro Gln Pro Leu His Thr Leu Val Leu Ala Ala 
            660                 665                 670         


Glu Glu Gly Ala Leu Val Ala Ala Val Glu Pro Gly Pro Leu Ala Asp 
        675                 680                 685             


Gly Ala Ala Val Arg Leu Ala Leu Ala Gly Glu Gly Glu Ala Cys Pro 
    690                 695                 700                 


Leu Leu Gly Ser Pro Gly Ala Gly Arg Asn Ser Val Leu Phe Leu Pro 
705                 710                 715                 720 


Val Asp Pro Glu Asp Ser Pro Leu Gly Ser Ser Thr Pro Met Ala Ser 
                725                 730                 735     


Pro Asp Leu Leu Pro Glu Asp Val Arg Glu His Leu Glu Gly Leu Met 
            740                 745                 750         


Leu Ser Leu Phe Glu Gln Ser Leu Ser Cys Gln Ala Gln Gly Gly Cys 
        755                 760                 765             


Ser Arg Pro Ala Met Val Leu Thr Asp Pro His Thr Pro Tyr Glu Glu 
    770                 775                 780                 


Glu Gln Arg Gln Ser Val Gln Ser Asp Gln Gly Tyr Ile Ser Arg Ser 
785                 790                 795                 800 


Ser Pro Gln Pro Pro Glu Gly Leu Thr Glu Met Glu Glu Glu Glu Glu 
                805                 810                 815     


Glu Glu Gln Asp Pro Gly Lys Pro Ala Leu Pro Leu Ser Pro Glu Asp 
            820                 825                 830         


Leu Glu Ser Leu Arg Ser Leu Gln Arg Gln Leu Leu Phe Arg Gln Leu 
        835                 840                 845             


Gln Lys Asn Ser Gly Trp Asp Thr Met Gly Ser Glu Ser Glu Gly Pro 
    850                 855                 860                 


Ser Ala 
865     


<210>  3919
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  3919

Met Gly Ala Ser Asp Pro Glu Val Ala Pro Trp Ala Arg Gly Gly Ala 
1               5                   10                  15      


Ala Gly Met Ala Gly Ala Gly Ala Gly Ala Gly Ala Arg Gly Gly Ala 
            20                  25                  30          


Ala Ala Gly Val Glu Ala Arg Ala Arg Asp Pro Pro Pro Ala His Arg 
        35                  40                  45              


Ala His Pro Arg His Pro Arg Pro Ala Ala Gln Pro Ser Ala Arg Arg 
    50                  55                  60                  


Met Asp Gly Gly Ser Gly Gly Leu Gly Ser Gly Asp Asn Ala Pro Thr 
65                  70                  75                  80  


Thr Glu Ala Leu Phe Val Ala Leu Gly Ala Gly Val Thr Ala Leu Ser 
                85                  90                  95      


His Pro Leu Leu Tyr Val Lys Leu Leu Ile Gln Val Gly His Glu Pro 
            100                 105                 110         


Met Pro Pro Thr Leu Gly Thr Asn Val Leu Gly Arg Lys Val Leu Tyr 
        115                 120                 125             


Leu Pro Ser Phe Phe Thr Tyr Ala Lys Tyr Ile Val Gln Val Asp Gly 
    130                 135                 140                 


Lys Ile Gly Leu Phe Arg Gly Leu Ser Pro Arg Leu Met Ser Asn Ala 
145                 150                 155                 160 


Leu Ser Thr Val Thr Arg Gly Ser Met Lys Lys Val Phe Pro Pro Asp 
                165                 170                 175     


Glu Ile Glu Gln Val Ser Asn Lys Asp Asp Met Lys Thr Ser Leu Lys 
            180                 185                 190         


Lys Val Val Lys Glu Thr Ser Tyr Glu Met Met Met Gln Cys Val Ser 
        195                 200                 205             


Arg Met Leu Ala His Pro Leu His Val Ile Ser Met Arg Cys Met Val 
    210                 215                 220                 


Gln Phe Val Gly Arg Glu Ala Lys Tyr Ser Gly Val Leu Ser Ser Ile 
225                 230                 235                 240 


Gly Lys Ile Phe Lys Glu Glu Gly Leu Leu Gly Phe Phe Val Gly Leu 
                245                 250                 255     


Ile Pro His Leu Leu Gly Asp Val Val Phe Leu Trp Gly Cys Asn Leu 
            260                 265                 270         


Leu Ala His Phe Ile Asn Ala Tyr Leu Val Asp Asp Ser Phe Ser Gln 
        275                 280                 285             


Ala Leu Ala Ile Arg Ser Tyr Thr Lys Phe Val Met Gly Ile Ala Val 
    290                 295                 300                 


Ser Met Leu Thr Tyr Pro Phe Leu Leu Val Gly Asp Leu Met Ala Val 
305                 310                 315                 320 


Asn Asn Cys Gly Leu Gln Ala Gly Leu Pro Pro Tyr Ser Pro Val Phe 
                325                 330                 335     


Lys Ser Trp Ile His Cys Trp Lys Tyr Leu Ser Val Gln Gly Gln Leu 
            340                 345                 350         


Phe Arg Gly Ser Ser Leu Leu Phe Arg Arg Val Ser Ser Gly Ser Cys 
        355                 360                 365             


Phe Ala Leu Glu 
    370         


<210>  3920
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  3920

Met Ser Met Ala Val Glu Thr Phe Gly Phe Phe Met Ala Thr Val Gly 
1               5                   10                  15      


Leu Leu Met Leu Gly Val Thr Leu Pro Asn Ser Tyr Trp Arg Val Ser 
            20                  25                  30          


Thr Val His Gly Asn Val Ile Thr Thr Asn Thr Ile Phe Glu Asn Leu 
        35                  40                  45              


Trp Phe Ser Cys Ala Thr Asp Ser Leu Gly Val Tyr Asn Cys Trp Glu 
    50                  55                  60                  


Phe Pro Ser Met Leu Ala Leu Ser Gly Tyr Ile Gln Ala Cys Arg Ala 
65                  70                  75                  80  


Leu Met Ile Thr Ala Ile Leu Leu Gly Phe Leu Gly Leu Leu Leu Gly 
                85                  90                  95      


Ile Ala Gly Leu Arg Cys Thr Asn Ile Gly Gly Leu Glu Leu Ser Arg 
            100                 105                 110         


Lys Ala Lys Leu Ala Ala Thr Ala Gly Ala Leu His Ile Leu Ala Gly 
        115                 120                 125             


Ile Cys Gly Met Val Ala Ile Ser Trp Tyr Ala Phe Asn Ile Thr Arg 
    130                 135                 140                 


Asp Phe Phe Asp Pro Leu Tyr Pro Gly Thr Lys Tyr Glu Leu Gly Pro 
145                 150                 155                 160 


Ala Leu Tyr Leu Gly Trp Ser Ala Ser Leu Ile Ser Ile Leu Gly Gly 
                165                 170                 175     


Leu Cys Leu Cys Ser Ala Cys Cys Cys Gly Ser Asp Glu Asp Pro Ala 
            180                 185                 190         


Ala Ser Ala Arg Arg Pro Tyr Gln Ala Pro Val Ser Val Met Pro Val 
        195                 200                 205             


Ala Thr Ser Asp Gln Glu Gly Asp Ser Ser Phe Gly Lys Tyr Gly Arg 
    210                 215                 220                 


Asn Ala Tyr Val 
225             


<210>  3921
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  3921

Met Gly Arg Arg Met Arg Gly Ala Ala Ala Thr Ala Gly Leu Trp Leu 
1               5                   10                  15      


Leu Ala Leu Gly Ser Leu Leu Ala Leu Trp Gly Gly Leu Leu Pro Pro 
            20                  25                  30          


Arg Thr Glu Leu Pro Ala Ser Arg Pro Pro Glu Asp Arg Leu Pro Arg 
        35                  40                  45              


Arg Pro Ala Arg Ser Gly Gly Pro Ala Pro Ala Pro Arg Phe Pro Leu 
    50                  55                  60                  


Pro Pro Pro Leu Ala Trp Asp Ala Arg Gly Gly Ser Leu Lys Thr Phe 
65                  70                  75                  80  


Arg Ala Leu Leu Thr Leu Ala Ala Gly Ala Asp Gly Pro Pro Arg Gln 
                85                  90                  95      


Ser Arg Ser Glu Pro Arg Trp His Val Ser Ala Arg Gln Pro Arg Pro 
            100                 105                 110         


Glu Glu Ser Ala Ala Val His Gly Gly Val Phe Trp Ser Arg Gly Leu 
        115                 120                 125             


Glu Glu Gln Val Pro Pro Gly Phe Ser Glu Ala Gln Ala Ala Ala Trp 
    130                 135                 140                 


Leu Glu Ala Ala Arg Gly Ala Arg Met Val Ala Leu Glu Arg Gly Gly 
145                 150                 155                 160 


Cys Gly Arg Ser Ser Asn Arg Leu Ala Arg Phe Ala Asp Gly Thr Arg 
                165                 170                 175     


Ala Cys Val Arg Tyr Gly Ile Asn Pro Glu Gln Ile Gln Gly Glu Ala 
            180                 185                 190         


Leu Ser Tyr Tyr Leu Ala Arg Leu Leu Gly Leu Gln Arg His Val Pro 
        195                 200                 205             


Pro Leu Ala Leu Ala Arg Val Glu Ala Arg Gly Ala Gln Trp Ala Gln 
    210                 215                 220                 


Val Gln Glu Glu Leu Arg Ala Ala His Trp Thr Glu Gly Ser Val Val 
225                 230                 235                 240 


Ser Leu Thr Arg Trp Leu Pro Asn Leu Thr Asp Val Val Val Pro Ala 
                245                 250                 255     


Pro Trp Arg Ser Glu Asp Gly Arg Leu Arg Pro Leu Arg Asp Ala Gly 
            260                 265                 270         


Gly Glu Leu Ala Asn Leu Ser Gln Ala Glu Leu Val Asp Leu Val Gln 
        275                 280                 285             


Trp Thr Asp Leu Ile Leu Phe Asp Tyr Leu Thr Ala Asn Phe Asp Arg 
    290                 295                 300                 


Leu Val Ser Asn Leu Phe Ser Leu Gln Trp Asp Pro Arg Val Met Gln 
305                 310                 315                 320 


Arg Ala Thr Ser Asn Leu His Arg Gly Pro Gly Gly Ala Leu Val Phe 
                325                 330                 335     


Leu Asp Asn Glu Ala Gly Leu Val His Gly Tyr Arg Val Ala Gly Met 
            340                 345                 350         


Trp Asp Lys Tyr Asn Glu Pro Leu Leu Gln Ser Val Cys Val Phe Arg 
        355                 360                 365             


Glu Arg Thr Ala Arg Arg Val Leu Glu Leu His Arg Gly Gln Asp Ala 
    370                 375                 380                 


Ala Ala Arg Leu Leu Arg Leu Tyr Arg Arg His Glu Pro Arg Phe Pro 
385                 390                 395                 400 


Glu Leu Ala Ala Leu Ala Asp Pro His Ala Gln Leu Leu Gln Arg Arg 
                405                 410                 415     


Leu Asp Phe Leu Ala Lys His Ile Leu His Cys Lys Ala Lys Tyr Gly 
            420                 425                 430         


Arg Arg Ser Gly Thr 
        435         


<210>  3922
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  3922

Met Asn Ser Ser Lys Ser Ser Glu Thr Gln Cys Thr Glu Arg Gly Cys 
1               5                   10                  15      


Phe Ser Ser Gln Met Phe Leu Trp Thr Val Ala Gly Ile Pro Ile Leu 
            20                  25                  30          


Phe Leu Ser Ala Cys Phe Ile Thr Arg Cys Val Val Thr Phe Arg Ile 
        35                  40                  45              


Phe Gln Thr Cys Asp Glu Lys Lys Phe Gln Leu Pro Glu Asn Phe Thr 
    50                  55                  60                  


Glu Leu Ser Cys Tyr Asn Tyr Gly Ser Gly Ser Val Lys Asn Cys Cys 
65                  70                  75                  80  


Pro Leu Asn Trp Glu Tyr Phe Gln Ser Ser Cys Tyr Phe Phe Ser Thr 
                85                  90                  95      


Asp Thr Ile Ser Trp Ala Leu Ser Leu Lys Asn Cys Ser Ala Met Gly 
            100                 105                 110         


Ala His Leu Val Val Ile Asn Ser Gln Glu Glu Gln Glu Phe Leu Ser 
        115                 120                 125             


Tyr Lys Lys Pro Lys Met Arg Glu Phe Phe Ile Gly Leu Ser Asp Gln 
    130                 135                 140                 


Val Val Glu Gly Gln Trp Gln Trp Val Asp Gly Thr Pro Leu Thr Lys 
145                 150                 155                 160 


Ser Leu Ser Phe Trp Asp Val Gly Glu Pro Asn Asn Ile Ala Thr Leu 
                165                 170                 175     


Glu Asp Cys Ala Thr Met Arg Asp Ser Ser Asn Pro Arg Gln Asn Trp 
            180                 185                 190         


Asn Asp Val Thr Cys Phe Leu Asn Tyr Phe Arg Ile Cys Glu Met Val 
        195                 200                 205             


Gly Ile Asn Pro Leu Asn Lys Gly Lys Ser Leu 
    210                 215                 


<210>  3923
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  3923

Met Gly Ser Leu Ser Gly Leu Arg Leu Ala Ala Gly Ser Cys Phe Arg 
1               5                   10                  15      


Leu Cys Glu Arg Asp Val Ser Ser Ser Leu Arg Leu Thr Arg Ser Ser 
            20                  25                  30          


Asp Leu Lys Arg Ile Asn Gly Phe Cys Thr Lys Pro Gln Glu Ser Pro 
        35                  40                  45              


Gly Ala Pro Ser Arg Thr Tyr Asn Arg Val Pro Leu His Lys Pro Thr 
    50                  55                  60                  


Asp Trp Gln Lys Lys Ile Leu Ile Trp Ser Gly Arg Phe Lys Lys Glu 
65                  70                  75                  80  


Asp Glu Ile Pro Glu Thr Val Ser Leu Glu Met Leu Asp Ala Ala Lys 
                85                  90                  95      


Asn Lys Met Arg Val Lys Ile Ser Tyr Leu Met Ile Ala Leu Thr Val 
            100                 105                 110         


Val Gly Cys Ile Phe Met Val Ile Glu Gly Lys Lys Ala Ala Gln Arg 
        115                 120                 125             


His Glu Thr Leu Thr Ser Leu Asn Leu Glu Lys Lys Ala Arg Leu Lys 
    130                 135                 140                 


Glu Glu Ala Ala Met Lys Ala Lys Thr Glu 
145                 150                 


<210>  3924
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  3924

Met Thr Ala Leu Ser Ser Glu Asn Cys Ser Phe Gln Tyr Gln Leu Arg 
1               5                   10                  15      


Gln Thr Asn Gln Pro Leu Asp Val Asn Tyr Leu Leu Phe Leu Ile Ile 
            20                  25                  30          


Leu Gly Lys Ile Leu Leu Asn Ile Leu Thr Leu Gly Met Arg Arg Lys 
        35                  40                  45              


Asn Thr Cys Gln Asn Phe Met Glu Tyr Phe Cys Ile Ser Leu Ala Phe 
    50                  55                  60                  


Val Asp Leu Leu Leu Leu Val Asn Ile Ser Ile Ile Leu Tyr Phe Arg 
65                  70                  75                  80  


Asp Phe Val Leu Leu Ser Ile Arg Phe Thr Lys Tyr His Ile Cys Leu 
                85                  90                  95      


Phe Thr Gln Ile Ile Ser Phe Thr Tyr Gly Phe Leu His Tyr Pro Val 
            100                 105                 110         


Phe Leu Thr Ala Cys Ile Asp Tyr Cys Leu Asn Phe Ser Lys Thr Thr 
        115                 120                 125             


Lys Leu Ser Phe Lys Cys Gln Lys Leu Phe Tyr Phe Phe Thr Val Ile 
    130                 135                 140                 


Leu Ile Trp Ile Ser Val Leu Ala Tyr Val Leu Gly Asp Pro Ala Ile 
145                 150                 155                 160 


Tyr Gln Ser Leu Lys Ala Gln Asn Ala Tyr Ser Arg His Cys Pro Phe 
                165                 170                 175     


Tyr Val Ser Ile Gln Ser Tyr Trp Leu Ser Phe Phe Met Val Met Ile 
            180                 185                 190         


Leu Phe Val Ala Phe Ile Thr Cys Trp Glu Glu Val Thr Thr Leu Val 
        195                 200                 205             


Gln Ala Ile Arg Ile Thr Ser Tyr Met Asn Glu Thr Ile Leu Tyr Phe 
    210                 215                 220                 


Pro Phe Ser Ser His Ser Ser Tyr Thr Val Arg Ser Lys Lys Ile Phe 
225                 230                 235                 240 


Leu Ser Lys Leu Ile Val Cys Phe Leu Ser Thr Trp Leu Pro Phe Val 
                245                 250                 255     


Leu Leu Gln Val Ile Ile Val Leu Leu Lys Val Gln Ile Pro Ala Tyr 
            260                 265                 270         


Ile Glu Met Asn Ile Pro Trp Leu Tyr Phe Val Asn Ser Phe Leu Ile 
        275                 280                 285             


Ala Thr Val Tyr Trp Phe Asn Cys His Lys Leu Asn Leu Lys Asp Ile 
    290                 295                 300                 


Gly Leu Pro Leu Asp Pro Phe Val Asn Trp Lys Cys Cys Phe Ile Pro 
305                 310                 315                 320 


Leu Thr Ile Pro Asn Leu Glu Gln Ile Glu Lys Pro Ile Ser Ile Met 
                325                 330                 335     


Ile Cys 
        


<210>  3925
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  3925

Met Pro Ser Ser Gly Arg Ala Leu Leu Asp Ser Pro Leu Asp Ser Gly 
1               5                   10                  15      


Ser Leu Thr Ser Leu Asp Ser Ser Val Phe Cys Ser Glu Gly Glu Gly 
            20                  25                  30          


Glu Pro Leu Ala Leu Gly Asp Cys Phe Thr Val Asn Val Gly Gly Ser 
        35                  40                  45              


Arg Phe Val Leu Ser Gln Gln Ala Leu Ser Cys Phe Pro His Thr Arg 
    50                  55                  60                  


Leu Gly Lys Leu Ala Val Val Val Ala Ser Tyr Arg Arg Pro Gly Ala 
65                  70                  75                  80  


Leu Ala Ala Val Pro Ser Pro Leu Glu Leu Cys Asp Asp Ala Asn Pro 
                85                  90                  95      


Val Asp Asn Glu Tyr Phe Phe Asp Arg Ser Ser Gln Ala Phe Arg Tyr 
            100                 105                 110         


Val Leu His Tyr Tyr Arg Thr Gly Arg Leu His Val Met Glu Gln Leu 
        115                 120                 125             


Cys Ala Leu Ser Phe Leu Gln Glu Ile Gln Tyr Trp Gly Ile Asp Glu 
    130                 135                 140                 


Leu Ser Ile Asp Ser Cys Cys Arg Asp Arg Tyr Phe Arg Arg Lys Glu 
145                 150                 155                 160 


Leu Ser Glu Thr Leu Asp Phe Lys Lys Asp Thr Glu Asp Gln Glu Ser 
                165                 170                 175     


Gln His Glu Ser Glu Gln Asp Phe Ser Gln Gly Pro Cys Pro Thr Val 
            180                 185                 190         


Arg Gln Lys Leu Trp Asn Ile Leu Glu Lys Pro Gly Ser Ser Thr Ala 
        195                 200                 205             


Ala Arg Ile Phe Gly Val Ile Ser Ile Ile Phe Val Val Val Ser Ile 
    210                 215                 220                 


Ile Asn Met Ala Leu Met Ser Ala Glu Leu Ser Trp Leu Asp Leu Gln 
225                 230                 235                 240 


Leu Leu Glu Ile Leu Glu Tyr Val Cys Ile Ser Trp Phe Thr Gly Glu 
                245                 250                 255     


Phe Val Leu Arg Phe Leu Cys Val Arg Asp Arg Cys Arg Phe Leu Arg 
            260                 265                 270         


Lys Val Pro Asn Ile Ile Asp Leu Leu Ala Ile Leu Pro Phe Tyr Ile 
        275                 280                 285             


Thr Leu Leu Val Glu Ser Leu Ser Gly Ser Gln Thr Thr Gln Glu Leu 
    290                 295                 300                 


Glu Asn Val Gly Arg Ile Val Gln Val Leu Arg Leu Leu Arg Ala Leu 
305                 310                 315                 320 


Arg Met Leu Lys Leu Gly Arg His Ser Thr Gly Leu Arg Ser Leu Gly 
                325                 330                 335     


Met Thr Ile Thr Gln Cys Tyr Glu Glu Val Gly Leu Leu Leu Leu Phe 
            340                 345                 350         


Leu Ser Val Gly Ile Ser Ile Phe Ser Thr Val Glu Tyr Phe Ala Glu 
        355                 360                 365             


Gln Ser Ile Pro Asp Thr Thr Phe Thr Ser Val Pro Cys Ala Trp Trp 
    370                 375                 380                 


Trp Ala Thr Thr Ser Met Thr Thr Val Gly Tyr Gly Asp Ile Arg Pro 
385                 390                 395                 400 


Asp Thr Thr Thr Gly Lys Ile Val Ala Phe Met Cys Ile Leu Ser Gly 
                405                 410                 415     


Ile Leu Val Leu Ala Leu Pro Ile Ala Ile Ile Asn Asp Arg Phe Ser 
            420                 425                 430         


Ala Cys Tyr Phe Thr Leu Lys Leu Lys Glu Ala Ala Val Arg Gln Arg 
        435                 440                 445             


Glu Ala Leu Lys Lys Leu Thr Lys Asn Ile Ala Thr Asp Ser Tyr Ile 
    450                 455                 460                 


Ser Val Asn Leu Arg Asp Val Tyr Ala Arg Ser Ile Met Glu Met Leu 
465                 470                 475                 480 


Arg Leu Lys Gly Arg Glu Arg Ala Ser Thr Arg Ser Ser Gly Gly Asp 
                485                 490                 495     


Asp Phe Trp Phe 
            500 


<210>  3926
<211>  919
<212>  PRT
<213>  Homo sapiens

<400>  3926

Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Thr 
1               5                   10                  15      


Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile 
            100                 105                 110         


Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
        115                 120                 125             


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
    130                 135                 140                 


Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly Asp Thr 
145                 150                 155                 160 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
                165                 170                 175     


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly Glu Thr 
            180                 185                 190         


Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr Asn Gly 
        195                 200                 205             


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu Val Arg 
    210                 215                 220                 


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn Ser Glu 
225                 230                 235                 240 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Thr 
                245                 250                 255     


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
            260                 265                 270         


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
        275                 280                 285             


Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala 
    290                 295                 300                 


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu Ala Leu 
305                 310                 315                 320 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
                325                 330                 335     


Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Thr 
            340                 345                 350         


Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Phe Thr Ser 
        355                 360                 365             


Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln Phe Gly 
    370                 375                 380                 


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
385                 390                 395                 400 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
                405                 410                 415     


Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu Ile Ala 
            420                 425                 430         


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
        435                 440                 445             


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
    450                 455                 460                 


Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
465                 470                 475                 480 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Gln Ser Lys 
                485                 490                 495     


Gly Gln Thr Leu Thr Leu Thr Gln Gln Gln Arg Asp Val Tyr Gln Gln 
            500                 505                 510         


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
        515                 520                 525             


Ser Gly Pro Glu Leu Gly Gln Leu Thr Phe Leu Gly Leu Val Gly Ile 
    530                 535                 540                 


Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr Leu Ile 
545                 550                 555                 560 


Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln Glu Thr 
                565                 570                 575     


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr Ser Gln 
            580                 585                 590         


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
        595                 600                 605             


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
    610                 615                 620                 


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
625                 630                 635                 640 


Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
                645                 650                 655     


Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys Glu Ala 
            660                 665                 670         


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala 
        675                 680                 685             


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
    690                 695                 700                 


Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser Leu Ala 
705                 710                 715                 720 


Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
                725                 730                 735     


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
            740                 745                 750         


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
        755                 760                 765             


Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
    770                 775                 780                 


Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
785                 790                 795                 800 


Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys Phe Val 
                805                 810                 815     


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr Lys Ser 
            820                 825                 830         


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
        835                 840                 845             


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
    850                 855                 860                 


Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Asp Leu Leu Phe 
865                 870                 875                 880 


Leu Leu Gly Leu Thr Ser Ser Val Cys Ile Val Ala Glu Ile Ile Lys 
                885                 890                 895     


Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Ser Ser Thr 
            900                 905                 910         


Ser Ser Ser Phe Leu Glu Val 
        915                 


<210>  3927
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  3927

Met Leu Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg Val 
1               5                   10                  15      


Glu Gly Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln Ser 
            20                  25                  30          


Ser Val Thr Val Gln Glu Gly Met Cys Val His Val Arg Cys Ser Phe 
        35                  40                  45              


Ser Tyr Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly Tyr 
    50                  55                  60                  


Trp Phe Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala Thr 
65                  70                  75                  80  


Asn Asn Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe His 
                85                  90                  95      


Leu Leu Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp 
            100                 105                 110         


Ala Arg Met Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly 
        115                 120                 125             


Asn Ile Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val Thr 
    130                 135                 140                 


Ala Leu Thr His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser 
145                 150                 155                 160 


Gly Cys Phe Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln 
                165                 170                 175     


Gly Thr Pro Pro Met Ile Ser Trp Met Gly Thr Ser Val Ser Pro Leu 
            180                 185                 190         


His Pro Ser Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro 
        195                 200                 205             


Gln His His Gly Thr Ser Leu Thr Cys Gln Val Thr Leu Pro Gly Ala 
    210                 215                 220                 


Gly Val Thr Thr Asn Arg Thr Ile Gln Leu Asn Val Ser Tyr Pro Pro 
225                 230                 235                 240 


Gln Asn Leu Thr Val Thr Val Phe Gln Gly Glu Gly Thr Ala Ser Thr 
                245                 250                 255     


Ala Leu Gly Asn Ser Ser Ser Leu Ser Val Leu Glu Gly Gln Ser Leu 
            260                 265                 270         


Arg Leu Val Cys Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Trp 
        275                 280                 285             


Thr Trp Arg Ser Leu Thr Leu Tyr Pro Ser Gln Pro Ser Asn Pro Leu 
    290                 295                 300                 


Val Leu Glu Leu Gln Val His Leu Gly Asp Glu Gly Glu Phe Thr Cys 
305                 310                 315                 320 


Arg Ala Gln Asn Ser Leu Gly Ser Gln His Val Ser Leu Asn Leu Ser 
                325                 330                 335     


Leu Gln Gln Glu Tyr Thr Gly Lys Met Arg Pro Val Ser Gly Val Leu 
            340                 345                 350         


Leu Gly Ala Val Gly Gly Ala Gly Ala Thr Ala Leu Val Phe Leu Ser 
        355                 360                 365             


Phe Cys Val Ile Phe Ile Val Val Arg Ser Cys Arg Lys Lys Ser Ala 
    370                 375                 380                 


Arg Pro Ala Ala Asp Val Gly Asp Ile Gly Met Lys Asp Ala Asn Thr 
385                 390                 395                 400 


Ile Arg Gly Ser Ala Ser Gln Gly Asn Leu Thr Glu Ser Trp Ala Asp 
                405                 410                 415     


Asp Asn Pro Arg His His Gly Leu Ala Ala His Ser Ser Gly Glu Glu 
            420                 425                 430         


Arg Glu Ile Gln Tyr Ala Pro Leu Ser Phe His Lys Gly Glu Pro Gln 
        435                 440                 445             


Asp Leu Ser Gly Gln Glu Ala Thr Asn Asn Glu Tyr Ser Glu Ile Lys 
    450                 455                 460                 


Ile Pro Lys 
465         


<210>  3928
<211>  613
<212>  PRT
<213>  Homo sapiens

<400>  3928

Met Ala Glu Ala Ser Arg Trp His Arg Gly Gly Ala Ser Lys His Lys 
1               5                   10                  15      


Leu His Tyr Arg Lys Glu Val Glu Ile Thr Thr Thr Leu Gln Glu Leu 
            20                  25                  30          


Leu Leu Tyr Phe Ile Phe Leu Ile Asn Leu Cys Ile Leu Thr Phe Gly 
        35                  40                  45              


Met Val Asn Pro His Met Tyr Tyr Leu Asn Lys Val Met Ser Ser Leu 
    50                  55                  60                  


Phe Leu Asp Thr Ser Val Pro Gly Glu Glu Arg Thr Asn Phe Lys Ser 
65                  70                  75                  80  


Ile Arg Ser Ile Thr Asp Phe Trp Lys Phe Met Glu Gly Pro Leu Leu 
                85                  90                  95      


Glu Gly Leu Tyr Trp Asp Ser Trp Tyr Asn Asn Gln Gln Leu Tyr Asn 
            100                 105                 110         


Leu Lys Asn Ser Ser Arg Ile Tyr Tyr Glu Asn Ile Leu Leu Gly Val 
        115                 120                 125             


Pro Arg Val Arg Gln Leu Lys Val Arg Asn Asn Thr Cys Lys Val Tyr 
    130                 135                 140                 


Ser Ser Phe Gln Ser Leu Met Ser Glu Cys Tyr Gly Lys Tyr Thr Ser 
145                 150                 155                 160 


Ala Asn Glu Asp Leu Ser Asn Phe Gly Leu Gln Ile Asn Thr Glu Trp 
                165                 170                 175     


Arg Tyr Ser Thr Ser Asn Thr Asn Ser Pro Trp His Trp Gly Phe Leu 
            180                 185                 190         


Gly Val Tyr Arg Asn Gly Gly Tyr Ile Phe Thr Leu Ser Lys Ser Lys 
        195                 200                 205             


Ser Glu Thr Lys Asn Lys Phe Ile Asp Leu Arg Leu Asn Ser Trp Ile 
    210                 215                 220                 


Thr Arg Gly Thr Arg Val Ile Phe Ile Asp Phe Ser Leu Tyr Asn Ala 
225                 230                 235                 240 


Asn Val Asn Leu Phe Cys Ile Ile Arg Leu Val Ala Glu Phe Pro Ala 
                245                 250                 255     


Thr Gly Gly Ile Leu Thr Ser Trp Gln Phe Tyr Ser Val Lys Leu Leu 
            260                 265                 270         


Arg Tyr Val Ser Tyr Tyr Asp Tyr Phe Ile Ala Ser Cys Glu Ile Thr 
        275                 280                 285             


Phe Cys Ile Phe Leu Phe Val Phe Thr Thr Gln Glu Val Lys Lys Ile 
    290                 295                 300                 


Lys Glu Phe Lys Ser Ala Tyr Phe Lys Ser Ile Trp Asn Trp Leu Glu 
305                 310                 315                 320 


Leu Leu Leu Leu Leu Leu Cys Phe Val Ala Val Ser Phe Asn Thr Tyr 
                325                 330                 335     


Tyr Asn Val Gln Ile Phe Leu Leu Leu Gly Gln Leu Leu Lys Ser Thr 
            340                 345                 350         


Glu Lys Tyr Ser Asp Phe Tyr Phe Leu Ala Cys Trp His Ile Tyr Tyr 
        355                 360                 365             


Asn Asn Ile Ile Ala Ile Thr Ile Phe Phe Ala Trp Ile Lys Ile Phe 
    370                 375                 380                 


Lys Phe Ile Ser Phe Asn Lys Thr Met Ser Gln Leu Ser Ser Thr Leu 
385                 390                 395                 400 


Ser Arg Cys Val Lys Asp Ile Val Gly Phe Ala Ile Met Phe Phe Ile 
                405                 410                 415     


Ile Phe Phe Ala Tyr Ala Gln Leu Gly Phe Leu Val Phe Gly Ser Gln 
            420                 425                 430         


Val Asp Asp Phe Ser Thr Phe Gln Asn Ser Ile Phe Ala Gln Phe Arg 
        435                 440                 445             


Ile Val Leu Gly Asp Phe Asn Phe Ala Gly Ile Gln Gln Ala Asn Pro 
    450                 455                 460                 


Ile Leu Gly Pro Ile Tyr Phe Ile Thr Phe Ile Phe Phe Val Phe Phe 
465                 470                 475                 480 


Val Leu Leu Asn Met Phe Leu Ala Ile Ile Asn Asp Thr Tyr Ser Glu 
                485                 490                 495     


Val Lys Ala Asp Tyr Ser Ile Gly Arg Arg Leu Asp Phe Glu Leu Gly 
            500                 505                 510         


Lys Met Ile Lys Gln Ser Tyr Lys Asn Val Leu Glu Lys Phe Arg Leu 
        515                 520                 525             


Lys Lys Ala Gln Lys Asp Glu Asp Lys Lys Thr Lys Gly Ser Gly Asp 
    530                 535                 540                 


Leu Ala Glu Gln Ala Arg Arg Glu Gly Phe Asp Glu Asn Glu Ile Gln 
545                 550                 555                 560 


Asn Ala Glu Gln Met Lys Lys Trp Lys Glu Arg Leu Glu Lys Lys Tyr 
                565                 570                 575     


Tyr Ser Met Glu Ile Gln Asp Asp Tyr Gln Pro Val Thr Gln Glu Glu 
            580                 585                 590         


Phe Arg Asp Gly Thr Thr Thr Lys Tyr Lys Met Arg Phe Ser Glu Cys 
        595                 600                 605             


Leu Thr Lys Arg Ile 
    610             


<210>  3929
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  3929

Met Val Lys Leu Gly Asn Asn Phe Ala Glu Lys Gly Thr Lys Gln Pro 
1               5                   10                  15      


Leu Leu Glu Asp Gly Phe Asp Thr Ile Pro Leu Met Thr Pro Leu Asp 
            20                  25                  30          


Val Asn Gln Leu Gln Phe Pro Pro Pro Asp Lys Val Val Val Lys Thr 
        35                  40                  45              


Lys Thr Glu Tyr Glu Pro Asp Arg Lys Lys Gly Lys Ala Arg Pro Pro 
    50                  55                  60                  


Gln Ile Ala Glu Phe Thr Val Ser Ile Thr Glu Gly Val Thr Glu Arg 
65                  70                  75                  80  


Phe Lys Val Ser Val Leu Val Leu Phe Ala Leu Ala Phe Leu Thr Cys 
                85                  90                  95      


Val Val Phe Leu Val Val Tyr Lys Val Tyr Lys Tyr Asp Arg Ala Cys 
            100                 105                 110         


Pro Asp Gly Phe Val Leu Lys Asn Thr Gln Cys Ile Pro Glu Gly Leu 
        115                 120                 125             


Glu Ser Tyr Tyr Ala Glu Gln Asp Ser Ser Ala Arg Glu Lys Phe Tyr 
    130                 135                 140                 


Thr Val Ile Asn His Tyr Asn Leu Ala Lys Gln Ser Ile Thr Arg Ser 
145                 150                 155                 160 


Val Ser Pro Trp Met Ser Val Leu Ser Glu Glu Lys Leu Ser Glu Gln 
                165                 170                 175     


Glu Thr Glu Ala Ala Glu Lys Ser Ala 
            180                 185 


<210>  3930
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  3930

Met Leu Ala Ala Arg Leu Val Cys Leu Arg Thr Leu Pro Ser Arg Val 
1               5                   10                  15      


Phe His Pro Ala Phe Thr Lys Ala Ser Pro Val Val Lys Asn Ser Ile 
            20                  25                  30          


Thr Lys Asn Gln Trp Leu Leu Thr Pro Ser Arg Glu Tyr Ala Thr Lys 
        35                  40                  45              


Thr Arg Ile Gly Ile Arg Arg Gly Arg Thr Gly Gln Glu Leu Lys Glu 
    50                  55                  60                  


Ala Ala Leu Glu Pro Ser Met Glu Lys Ile Phe Lys Ile Asp Gln Met 
65                  70                  75                  80  


Gly Arg Trp Phe Val Ala Gly Gly Ala Ala Val Gly Leu Gly Ala Leu 
                85                  90                  95      


Cys Tyr Tyr Gly Leu Gly Leu Ser Asn Glu Ile Gly Ala Ile Glu Lys 
            100                 105                 110         


Ala Val Ile Trp Pro Gln Tyr Val Lys Asp Arg Ile His Ser Thr Tyr 
        115                 120                 125             


Met Tyr Leu Ala Gly Ser Ile Gly Leu Thr Ala Leu Ser Ala Ile Ala 
    130                 135                 140                 


Ile Ser Arg Thr Pro Val Leu Met Asn Phe Met Met Arg Gly Ser Trp 
145                 150                 155                 160 


Val Thr Ile Gly Val Thr Phe Ala Ala Met Val Gly Ala Gly Met Leu 
                165                 170                 175     


Val Arg Ser Ile Pro Tyr Asp Gln Ser Pro Gly Pro Lys His Leu Ala 
            180                 185                 190         


Trp Leu Leu His Ser Gly Val Met Gly Ala Val Val Ala Pro Leu Thr 
        195                 200                 205             


Ile Leu Gly Gly Pro Leu Leu Ile Arg Ala Ala Trp Tyr Thr Ala Gly 
    210                 215                 220                 


Ile Val Gly Gly Leu Ser Thr Val Ala Met Cys Ala Pro Ser Glu Lys 
225                 230                 235                 240 


Phe Leu Asn Met Gly Ala Pro Leu Gly Val Gly Leu Gly Leu Val Phe 
                245                 250                 255     


Val Ser Ser Leu Gly Ser Met Phe Leu Pro Pro Thr Thr Val Ala Gly 
            260                 265                 270         


Ala Thr Leu Tyr Ser Val Ala Met Tyr Gly Gly Leu Val Leu Phe Ser 
        275                 280                 285             


Met Phe Leu Leu Tyr Asp Thr Gln Lys Val Ile Lys Arg Ala Glu Val 
    290                 295                 300                 


Ser Pro Met Tyr Gly Val Gln Lys Tyr Asp Pro Ile Asn Ser Met Leu 
305                 310                 315                 320 


Ser Ile Tyr Met Asp Thr Leu Asn Ile Phe Met Arg Val Ala Thr Met 
                325                 330                 335     


Leu Ala Thr Gly Gly Asn Arg Lys Lys 
            340                 345 


<210>  3931
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  3931

Met Pro Arg Gln Leu Ser Ala Ala Ala Ala Leu Phe Ala Ser Leu Ala 
1               5                   10                  15      


Val Ile Leu His Asp Gly Ser Gln Met Arg Ala Lys Ala Phe Pro Glu 
            20                  25                  30          


Thr Arg Asp Tyr Ser Gln Pro Thr Ala Ala Ala Thr Val Gln Asp Ile 
        35                  40                  45              


Lys Lys Pro Val Gln Gln Pro Ala Lys Gln Ala Pro His Gln Thr Leu 
    50                  55                  60                  


Ala Ala Arg Phe Met Asp Gly His Ile Thr Phe Gln Thr Ala Ala Thr 
65                  70                  75                  80  


Val Lys Ile Pro Thr Thr Thr Pro Ala Thr Thr Lys Asn Thr Ala Thr 
                85                  90                  95      


Thr Ser Pro Ile Thr Tyr Thr Leu Val Thr Thr Gln Ala Thr Pro Asn 
            100                 105                 110         


Asn Ser His Thr Ala Pro Pro Val Thr Glu Val Thr Val Gly Pro Ser 
        115                 120                 125             


Leu Ala Pro Tyr Ser Leu Pro Pro Thr Ile Thr Pro Pro Ala His Thr 
    130                 135                 140                 


Thr Gly Thr Ser Ser Ser Thr Val Ser His Thr Thr Gly Asn Thr Thr 
145                 150                 155                 160 


Gln Pro Ser Asn Gln Thr Thr Leu Pro Ala Thr Leu Ser Ile Ala Leu 
                165                 170                 175     


His Lys Ser Thr Thr Gly Gln Lys Pro Val Gln Pro Thr His Ala Pro 
            180                 185                 190         


Gly Thr Thr Ala Ala Ala His Asn Thr Thr Arg Thr Ala Ala Pro Ala 
        195                 200                 205             


Ser Thr Val Pro Gly Pro Thr Leu Ala Pro Gln Pro Ser Ser Val Lys 
    210                 215                 220                 


Thr Gly Ile Tyr Gln Val Leu Asn Gly Ser Arg Leu Cys Ile Lys Ala 
225                 230                 235                 240 


Glu Met Gly Ile Gln Leu Ile Val Gln Asp Lys Glu Ser Val Phe Ser 
                245                 250                 255     


Pro Arg Arg Tyr Phe Asn Ile Asp Pro Asn Ala Thr Gln Ala Ser Gly 
            260                 265                 270         


Asn Cys Gly Thr Arg Lys Ser Asn Leu Leu Leu Asn Phe Gln Gly Gly 
        275                 280                 285             


Phe Val Asn Leu Thr Phe Thr Lys Asp Glu Glu Ser Tyr Tyr Ile Ser 
    290                 295                 300                 


Glu Val Gly Ala Tyr Leu Thr Val Ser Asp Pro Glu Thr Ile Tyr Gln 
305                 310                 315                 320 


Gly Ile Lys His Ala Val Val Met Phe Gln Thr Ala Val Gly His Ser 
                325                 330                 335     


Phe Lys Cys Val Ser Glu Gln Ser Leu Gln Leu Ser Ala His Leu Gln 
            340                 345                 350         


Val Lys Thr Thr Asp Val Gln Leu Gln Ala Phe Asp Phe Glu Asp Asp 
        355                 360                 365             


His Phe Gly Asn Val Asp Glu Cys Ser Ser Asp Tyr Thr Ile Val Leu 
    370                 375                 380                 


Pro Val Ile Gly Ala Ile Val Val Gly Leu Cys Leu Met Gly Met Gly 
385                 390                 395                 400 


Val Tyr Lys Ile Arg Leu Arg Cys Gln Ser Ser Gly Tyr Gln Arg Ile 
                405                 410                 415     


<210>  3932
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  3932

Met Val Cys Gly Gly Phe Ala Cys Ser Lys Asn Cys Leu Cys Ala Leu 
1               5                   10                  15      


Asn Leu Leu Tyr Thr Leu Val Ser Leu Leu Leu Ile Gly Ile Ala Ala 
            20                  25                  30          


Trp Gly Ile Gly Phe Gly Leu Ile Ser Ser Leu Arg Val Val Gly Val 
        35                  40                  45              


Val Ile Ala Val Gly Ile Phe Leu Phe Leu Ile Ala Leu Val Gly Leu 
    50                  55                  60                  


Ile Gly Ala Val Lys His His Gln Val Leu Leu Phe Phe Tyr Met Ile 
65                  70                  75                  80  


Ile Leu Leu Leu Val Phe Ile Val Gln Phe Ser Val Ser Cys Ala Cys 
                85                  90                  95      


Leu Ala Leu Asn Gln Glu Gln Gln Gly Gln Leu Leu Glu Val Gly Trp 
            100                 105                 110         


Asn Asn Thr Ala Ser Ala Arg Asn Asp Ile Gln Arg Asn Leu Asn Cys 
        115                 120                 125             


Cys Gly Phe Arg Ser Val Asn Pro Asn Asp Thr Cys Leu Ala Ser Cys 
    130                 135                 140                 


Val Lys Ser Asp His Ser Cys Ser Pro Cys Ala Pro Ile Ile Gly Glu 
145                 150                 155                 160 


Tyr Ala Gly Glu Val Leu Arg Phe Val Gly Gly Ile Gly Leu Phe Phe 
                165                 170                 175     


Ser Phe Thr Glu Ile Leu Gly Val Trp Leu Thr Tyr Arg Tyr Arg Asn 
            180                 185                 190         


Gln Lys Asp Pro Arg Ala Asn Pro Ser Ala Phe Leu 
        195                 200                 


<210>  3933
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  3933

Met Ser Ala Cys Gly Arg Lys Ala Leu Thr Leu Leu Ser Ser Val Phe 
1               5                   10                  15      


Ala Val Cys Gly Leu Gly Leu Leu Gly Ile Ala Val Ser Thr Asp Tyr 
            20                  25                  30          


Trp Leu Tyr Leu Glu Glu Gly Val Ile Val Pro Gln Asn Gln Ser Thr 
        35                  40                  45              


Glu Ile Lys Met Ser Leu His Ser Gly Leu Trp Arg Val Cys Phe Leu 
    50                  55                  60                  


Ala Gly Glu Glu Arg Gly Arg Cys Phe Thr Ile Glu Tyr Val Met Pro 
65                  70                  75                  80  


Met Asn Thr Gln Leu Thr Ser Glu Ser Thr Val Asn Val Leu Lys Met 
                85                  90                  95      


Ile Arg Ser Ala Thr Pro Phe Pro Leu Val Ser Leu Phe Phe Met Phe 
            100                 105                 110         


Ile Gly Phe Ile Leu Asn Asn Ile Gly His Ile Arg Pro His Arg Thr 
        115                 120                 125             


Ile Leu Ala Phe Val Ser Gly Ile Phe Phe Ile Leu Ser Gly Leu Ser 
    130                 135                 140                 


Leu Val Val Gly Leu Val Leu Tyr Ile Ser Ser Ile Asn Asp Glu Met 
145                 150                 155                 160 


Leu Asn Arg Thr Lys Asp Ala Glu Thr Tyr Phe Asn Tyr Lys Tyr Gly 
                165                 170                 175     


Trp Ser Phe Ala Phe Ala Ala Ile Ser Phe Leu Leu Thr Glu Ser Ala 
            180                 185                 190         


Gly Val Met Ser Val Tyr Leu Phe Met Lys Arg Tyr Thr Ala Glu Asp 
        195                 200                 205             


Met Tyr Arg Pro His Pro Gly Phe Tyr Arg Pro Arg Leu Ser Asn Cys 
    210                 215                 220                 


Ser Asp Tyr Ser Gly Gln Phe Leu His Pro Asp Ala Trp Val Arg Gly 
225                 230                 235                 240 


Arg Ser Pro Ser Asp Ile Ser Ser Glu Ala Ser Leu Gln Met Asn Ser 
                245                 250                 255     


Asn Tyr Pro Ala Leu Leu Lys Cys Pro Asp Tyr Asp Gln Met Ser Ser 
            260                 265                 270         


Ser Pro Cys 
        275 


<210>  3934
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  3934

Met Val Arg Cys Asp Arg Gly Leu Gln Met Leu Leu Thr Thr Ala Gly 
1               5                   10                  15      


Ala Phe Ala Ala Phe Ser Leu Met Ala Ile Ala Ile Gly Thr Asp Tyr 
            20                  25                  30          


Trp Leu Tyr Ser Ser Ala His Ile Cys Asn Gly Thr Asn Leu Thr Met 
        35                  40                  45              


Asp Asp Gly Pro Pro Pro Arg Arg Ala Arg Gly Asp Leu Thr His Ser 
    50                  55                  60                  


Gly Leu Trp Arg Val Cys Cys Ile Glu Gly Ile Tyr Lys Gly His Cys 
65                  70                  75                  80  


Phe Arg Ile Asn His Phe Pro Glu Asp Asn Asp Tyr Asp His Asp Ser 
                85                  90                  95      


Ser Glu Tyr Leu Leu Arg Ile Val Arg Ala Ser Ser Val Phe Pro Ile 
            100                 105                 110         


Leu Ser Thr Ile Leu Leu Leu Leu Gly Gly Leu Cys Ile Gly Ala Gly 
        115                 120                 125             


Arg Ile Tyr Ser Arg Lys Asn Asn Ile Val Leu Ser Ala Gly Ile Leu 
    130                 135                 140                 


Phe Val Ala Ala Gly Leu Ser Asn Ile Ile Gly Ile Ile Val Tyr Ile 
145                 150                 155                 160 


Ser Ser Asn Thr Gly Asp Pro Ser Asp Lys Arg Asp Glu Asp Lys Lys 
                165                 170                 175     


Asn His Tyr Asn Tyr Gly Trp Ser Phe Tyr Phe Gly Ala Leu Ser Phe 
            180                 185                 190         


Ile Val Ala Glu Thr Val Gly Val Leu Ala Val Asn Ile Tyr Ile Glu 
        195                 200                 205             


Lys Asn Lys Glu Leu Arg Phe Lys Thr Lys Arg Glu Phe Leu Lys Ala 
    210                 215                 220                 


Ser Ser Ser Ser Pro Tyr Ala Arg Met Pro Ser Tyr Arg Tyr Arg Arg 
225                 230                 235                 240 


Arg Arg Ser Arg Ser Ser Ser Arg Ser Thr Glu Ala Ser Pro Ser Arg 
                245                 250                 255     


Asp Val Ser Pro Met Gly Leu Lys Ile Thr Gly Ala Ile Pro Met Gly 
            260                 265                 270         


Glu Leu Ser Met Tyr Thr Leu Ser Arg Glu Pro Leu Lys Val Thr Thr 
        275                 280                 285             


Ala Ala Ser Tyr Ser Pro Asp Gln Glu Ala Ser Phe Leu Gln Val His 
    290                 295                 300                 


Asp Phe Phe Gln Gln Asp Leu Lys Glu Gly Phe His Val Ser Met Leu 
305                 310                 315                 320 


Asn Arg Arg Thr Thr Pro Val 
                325         


<210>  3935
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  3935

Met Gly Glu Ala Ser Pro Pro Ala Pro Ala Arg Arg His Leu Leu Val 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ser Thr Leu Val Ile Pro Ser Ala Ala Ala Pro 
            20                  25                  30          


Ile His Asp Ala Asp Ala Gln Glu Ser Ser Leu Gly Leu Thr Gly Leu 
        35                  40                  45              


Gln Ser Leu Leu Gln Gly Phe Ser Arg Leu Phe Leu Lys Gly Asn Leu 
    50                  55                  60                  


Leu Arg Gly Ile Asp Ser Leu Phe Ser Ala Pro Met Asp Phe Arg Gly 
65                  70                  75                  80  


Leu Pro Gly Asn Tyr His Lys Glu Glu Asn Gln Glu His Gln Leu Gly 
                85                  90                  95      


Asn Asn Thr Leu Ser Ser His Leu Gln Ile Asp Lys Met Thr Asp Asn 
            100                 105                 110         


Lys Thr Gly Glu Val Leu Ile Ser Glu Asn Val Val Ala Ser Ile Gln 
        115                 120                 125             


Pro Ala Glu Gly Ser Phe Glu Gly Asp Leu Lys Val Pro Arg Met Glu 
    130                 135                 140                 


Glu Lys Glu Ala Leu Val Pro Ile Gln Lys Ala Thr Asp Ser Phe His 
145                 150                 155                 160 


Thr Glu Leu His Pro Arg Val Ala Phe Trp Ile Ile Lys Leu Pro Arg 
                165                 170                 175     


Arg Arg Ser His Gln Asp Ala Leu Glu Gly Gly His Trp Leu Ser Glu 
            180                 185                 190         


Lys Arg His Arg Leu Gln Ala Ile Arg Asp Gly Leu Arg Lys Gly Thr 
        195                 200                 205             


His Lys Asp Val Leu Glu Glu Gly Thr Glu Ser Ser Ser His Ser Arg 
    210                 215                 220                 


Leu Ser Pro Arg Lys Thr His Leu Leu Tyr Ile Leu Arg Pro Ser Arg 
225                 230                 235                 240 


Gln Leu 
        


<210>  3936
<211>  553
<212>  PRT
<213>  Homo sapiens

<400>  3936

Met Arg Ala Pro Gly Arg Pro Ala Leu Arg Pro Leu Pro Leu Pro Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ala Ala Pro Trp Gly Arg Ala Val Pro Cys 
            20                  25                  30          


Val Ser Gly Gly Leu Pro Lys Pro Ala Asn Ile Thr Phe Leu Ser Ile 
        35                  40                  45              


Asn Met Lys Asn Val Leu Gln Trp Thr Pro Pro Glu Gly Leu Gln Gly 
    50                  55                  60                  


Val Lys Val Thr Tyr Thr Val Gln Tyr Phe Ile Tyr Gly Gln Lys Lys 
65                  70                  75                  80  


Trp Leu Asn Lys Ser Glu Cys Arg Asn Ile Asn Arg Thr Tyr Cys Asp 
                85                  90                  95      


Leu Ser Ala Glu Thr Ser Asp Tyr Glu His Gln Tyr Tyr Ala Lys Val 
            100                 105                 110         


Lys Ala Ile Trp Gly Thr Lys Cys Ser Lys Trp Ala Glu Ser Gly Arg 
        115                 120                 125             


Phe Tyr Pro Phe Leu Glu Thr Gln Ile Gly Pro Pro Glu Val Ala Leu 
    130                 135                 140                 


Thr Thr Asp Glu Lys Ser Ile Ser Val Val Leu Thr Ala Pro Glu Lys 
145                 150                 155                 160 


Trp Lys Arg Asn Pro Glu Asp Leu Pro Val Ser Met Gln Gln Ile Tyr 
                165                 170                 175     


Ser Asn Leu Lys Tyr Asn Val Ser Val Leu Asn Thr Lys Ser Asn Arg 
            180                 185                 190         


Thr Trp Ser Gln Cys Val Thr Asn His Thr Leu Val Leu Thr Trp Leu 
        195                 200                 205             


Glu Pro Asn Thr Leu Tyr Cys Val His Val Glu Ser Phe Val Pro Gly 
    210                 215                 220                 


Pro Pro Arg Arg Ala Gln Pro Ser Glu Lys Gln Cys Ala Arg Thr Leu 
225                 230                 235                 240 


Lys Asp Gln Ser Ser Glu Phe Lys Ala Lys Ile Ile Phe Trp Tyr Val 
                245                 250                 255     


Leu Pro Ile Ser Ile Thr Val Phe Leu Phe Ser Val Met Gly Tyr Ser 
            260                 265                 270         


Ile Tyr Arg Tyr Ile His Val Gly Lys Glu Lys His Pro Ala Asn Leu 
        275                 280                 285             


Ile Leu Ile Tyr Gly Asn Glu Phe Asp Lys Arg Phe Phe Val Pro Ala 
    290                 295                 300                 


Glu Lys Ile Val Ile Asn Phe Ile Thr Leu Asn Ile Ser Asp Asp Ser 
305                 310                 315                 320 


Lys Ile Ser His Gln Asp Met Ser Leu Leu Gly Lys Ser Ser Asp Val 
                325                 330                 335     


Ser Ser Leu Asn Asp Pro Gln Pro Ser Gly Asn Leu Arg Pro Pro Gln 
            340                 345                 350         


Glu Glu Glu Glu Val Lys His Leu Gly Tyr Ala Ser His Leu Met Glu 
        355                 360                 365             


Ile Phe Cys Asp Ser Glu Glu Asn Thr Glu Gly Thr Ser Leu Thr Gln 
    370                 375                 380                 


Gln Glu Ser Leu Ser Arg Thr Ile Pro Pro Asp Lys Thr Val Ile Glu 
385                 390                 395                 400 


Tyr Glu Tyr Asp Val Arg Thr Thr Asp Ile Cys Ala Gly Pro Glu Glu 
                405                 410                 415     


Gln Glu Leu Ser Leu Gln Glu Glu Val Ser Thr Gln Gly Thr Leu Leu 
            420                 425                 430         


Glu Ser Gln Ala Ala Leu Ala Val Leu Gly Pro Gln Thr Leu Gln Tyr 
        435                 440                 445             


Ser Tyr Thr Pro Gln Leu Gln Asp Leu Asp Pro Leu Ala Gln Glu His 
    450                 455                 460                 


Thr Asp Ser Glu Glu Gly Pro Glu Glu Glu Pro Ser Thr Thr Leu Val 
465                 470                 475                 480 


Asp Trp Asp Pro Gln Thr Gly Arg Leu Cys Ile Pro Ser Leu Ser Ser 
                485                 490                 495     


Phe Asp Gln Asp Ser Glu Gly Cys Glu Pro Ser Glu Gly Asp Gly Leu 
            500                 505                 510         


Gly Glu Glu Gly Leu Leu Ser Arg Leu Tyr Glu Glu Pro Ala Pro Asp 
        515                 520                 525             


Arg Pro Pro Gly Glu Asn Glu Thr Tyr Leu Met Gln Phe Met Glu Glu 
    530                 535                 540                 


Trp Gly Leu Tyr Val Gln Met Glu Asn 
545                 550             


<210>  3937
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  3937

Met Arg Thr Ala Asp Arg Glu Ala Arg Pro Gly Leu Pro Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ala Gly Ala Gly Leu Ser Ala Ala Ser Pro Pro Ala 
            20                  25                  30          


Ala Pro Arg Phe Asn Val Ser Leu Asp Ser Val Pro Glu Leu Arg Trp 
        35                  40                  45              


Leu Pro Val Leu Arg His Tyr Asp Leu Asp Leu Val Arg Ala Ala Met 
    50                  55                  60                  


Ala Gln Val Ile Gly Asp Arg Val Pro Lys Trp Val His Val Leu Ile 
65                  70                  75                  80  


Gly Lys Val Val Leu Glu Leu Glu Arg Phe Leu Pro Gln Pro Phe Thr 
                85                  90                  95      


Gly Glu Ile Arg Gly Met Cys Asp Phe Met Asn Leu Ser Leu Ala Asp 
            100                 105                 110         


Cys Leu Leu Val Asn Leu Ala Tyr Glu Ser Ser Val Phe Cys Thr Ser 
        115                 120                 125             


Ile Val Ala Gln Asp Ser Arg Gly His Ile Tyr His Gly Arg Asn Leu 
    130                 135                 140                 


Asp Tyr Pro Phe Gly Asn Val Leu Arg Lys Leu Thr Val Asp Val Gln 
145                 150                 155                 160 


Phe Leu Lys Asn Gly Gln Ile Ala Phe Thr Gly Thr Thr Phe Ile Gly 
                165                 170                 175     


Tyr Val Gly Leu Trp Thr Gly Gln Ser Pro His Lys Phe Thr Val Ser 
            180                 185                 190         


Gly Asp Glu Arg Asp Lys Gly Trp Trp Trp Glu Asn Ala Ile Ala Ala 
        195                 200                 205             


Leu Phe Arg Arg His Ile Pro Val Ser Trp Leu Ile Arg Ala Thr Leu 
    210                 215                 220                 


Ser Glu Ser Glu Asn Phe Glu Ala Ala Val Gly Lys Leu Ala Lys Thr 
225                 230                 235                 240 


Pro Leu Ile Ala Asp Val Tyr Tyr Ile Val Gly Gly Thr Ser Pro Arg 
                245                 250                 255     


Glu Gly Val Val Ile Thr Arg Asn Arg Asp Gly Pro Ala Asp Ile Trp 
            260                 265                 270         


Pro Leu Asp Pro Leu Asn Gly Ala Trp Phe Arg Val Glu Thr Asn Tyr 
        275                 280                 285             


Asp His Trp Lys Pro Ala Pro Lys Glu Asp Asp Arg Arg Thr Ser Ala 
    290                 295                 300                 


Ile Lys Ala Leu Asn Ala Thr Gly Gln Ala Asn Leu Ser Leu Glu Ala 
305                 310                 315                 320 


Leu Phe Gln Ile Leu Ser Val Val Pro Val Tyr Asn Asn Phe Thr Ile 
                325                 330                 335     


Tyr Thr Thr Val Met Ser Ala Gly Ser Pro Asp Lys Tyr Met Thr Arg 
            340                 345                 350         


Ile Arg Asn Pro Ser Arg Lys 
        355                 


<210>  3938
<211>  324
<212>  PRT
<213>  Homo sapiens

<400>  3938

Met Gly Pro Trp Gly Glu Pro Glu Leu Leu Val Trp Arg Pro Glu Ala 
1               5                   10                  15      


Val Ala Ser Glu Pro Pro Val Pro Val Gly Leu Glu Val Lys Leu Gly 
            20                  25                  30          


Ala Leu Val Leu Leu Leu Val Leu Thr Leu Leu Cys Ser Leu Val Pro 
        35                  40                  45              


Ile Cys Val Leu Arg Arg Pro Gly Ala Asn His Glu Gly Ser Ala Ser 
    50                  55                  60                  


Arg Gln Lys Ala Leu Ser Leu Val Ser Cys Phe Ala Gly Gly Val Phe 
65                  70                  75                  80  


Leu Ala Thr Cys Leu Leu Asp Leu Leu Pro Asp Tyr Leu Ala Ala Ile 
                85                  90                  95      


Asp Glu Ala Leu Ala Ala Leu His Val Thr Leu Gln Phe Pro Leu Gln 
            100                 105                 110         


Glu Phe Ile Leu Ala Met Gly Phe Phe Leu Val Leu Val Met Glu Gln 
        115                 120                 125             


Ile Thr Leu Ala Tyr Lys Glu Gln Ser Gly Pro Ser Pro Leu Glu Glu 
    130                 135                 140                 


Thr Arg Ala Leu Leu Gly Thr Val Asn Gly Gly Pro Gln His Trp His 
145                 150                 155                 160 


Asp Gly Pro Gly Val Pro Gln Ala Ser Gly Ala Pro Ala Thr Pro Ser 
                165                 170                 175     


Ala Leu Arg Ala Cys Val Leu Val Phe Ser Leu Ala Leu His Ser Val 
            180                 185                 190         


Phe Glu Gly Leu Ala Val Gly Leu Gln Arg Asp Arg Ala Arg Ala Met 
        195                 200                 205             


Glu Leu Cys Leu Ala Leu Leu Leu His Lys Gly Ile Leu Ala Val Ser 
    210                 215                 220                 


Leu Ser Leu Arg Leu Leu Gln Ser His Leu Arg Ala Gln Val Val Ala 
225                 230                 235                 240 


Gly Cys Gly Ile Leu Phe Ser Cys Met Thr Pro Leu Gly Ile Gly Leu 
                245                 250                 255     


Gly Ala Ala Leu Ala Glu Ser Ala Gly Pro Leu His Gln Leu Ala Gln 
            260                 265                 270         


Ser Val Leu Glu Gly Met Ala Ala Gly Thr Phe Leu Tyr Ile Thr Phe 
        275                 280                 285             


Leu Glu Ile Leu Pro Gln Glu Leu Ala Ser Ser Glu Gln Arg Ile Leu 
    290                 295                 300                 


Lys Val Ile Leu Leu Leu Ala Gly Phe Ala Leu Leu Thr Gly Leu Leu 
305                 310                 315                 320 


Phe Ile Gln Ile 
                


<210>  3939
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  3939

Met Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg Ala Glu 
1               5                   10                  15      


Gly Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 
    50                  55                  60                  


Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 
65                  70                  75                  80  


Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 
                85                  90                  95      


Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 
            100                 105                 110         


Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 
        115                 120                 125             


Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 
    130                 135                 140                 


Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 
145                 150                 155                 160 


Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 
                165                 170                 175     


Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 
            180                 185                 190         


Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 
        195                 200                 205             


Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 
    210                 215                 220                 


Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 
225                 230                 235                 240 


Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 
                245                 250                 255     


Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 
            260                 265                 270         


Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 
        275                 280                 285             


Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 
    290                 295                 300                 


Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 
305                 310                 315                 320 


Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 
                325                 330                 335     


Leu Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Val Val Gly Gly 
            340                 345                 350         


Ala Gly Ala Thr Ala Leu Val Phe Leu Ser Phe Cys Val Ile Phe Val 
        355                 360                 365             


Val Val Arg Ser Cys Arg Lys Lys Ser Ala Arg Pro Ala Ala Gly Val 
    370                 375                 380                 


Gly Asp Thr Gly Ile Glu Asp Ala Asn Ala Val Arg Gly Ser Ala Ser 
385                 390                 395                 400 


Gln Gly Pro Leu Thr Glu Pro Trp Ala Glu Asp Ser Pro Pro Asp Gln 
                405                 410                 415     


Pro Pro Pro Ala Ser Ala Arg Ser Ser Val Gly Glu Gly Glu Leu Gln 
            420                 425                 430         


Tyr Ala Ser Leu Ser Phe Gln Met Val Lys Pro Trp Asp Ser Arg Gly 
        435                 440                 445             


Gln Glu Ala Thr Asp Thr Glu Tyr Ser Glu Ile Lys Ile His Arg 
    450                 455                 460             


<210>  3940
<211>  499
<212>  PRT
<213>  Homo sapiens

<400>  3940

Met Leu Leu Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Thr Lys Gly 
1               5                   10                  15      


Met Glu Gly Asp Arg Gln Tyr Gly Asp Gly Tyr Leu Leu Gln Val Gln 
            20                  25                  30          


Glu Leu Val Thr Val Gln Glu Gly Leu Cys Val His Val Pro Cys Ser 
        35                  40                  45              


Phe Ser Tyr Pro Gln Asp Gly Trp Thr Asp Ser Asp Pro Val His Gly 
    50                  55                  60                  


Tyr Trp Phe Arg Ala Gly Asp Arg Pro Tyr Gln Asp Ala Pro Val Ala 
65                  70                  75                  80  


Thr Asn Asn Pro Asp Arg Glu Val Gln Ala Glu Thr Gln Gly Arg Phe 
                85                  90                  95      


Gln Leu Leu Gly Asp Ile Trp Ser Asn Asp Cys Ser Leu Ser Ile Arg 
            100                 105                 110         


Asp Ala Arg Lys Arg Asp Lys Gly Ser Tyr Phe Phe Arg Leu Glu Arg 
        115                 120                 125             


Gly Ser Met Lys Trp Ser Tyr Lys Ser Gln Leu Asn Tyr Lys Thr Lys 
    130                 135                 140                 


Gln Leu Ser Val Phe Val Thr Ala Leu Thr His Arg Pro Asp Ile Leu 
145                 150                 155                 160 


Ile Leu Gly Thr Leu Glu Ser Gly His Ser Arg Asn Leu Thr Cys Ser 
                165                 170                 175     


Val Pro Trp Ala Cys Lys Gln Gly Thr Pro Pro Met Ile Ser Trp Ile 
            180                 185                 190         


Gly Ala Ser Val Ser Ser Pro Gly Pro Thr Thr Ala Arg Ser Ser Val 
        195                 200                 205             


Leu Thr Leu Thr Pro Lys Pro Gln Asp His Gly Thr Ser Leu Thr Cys 
    210                 215                 220                 


Gln Val Thr Leu Pro Gly Thr Gly Val Thr Thr Thr Ser Thr Val Arg 
225                 230                 235                 240 


Leu Asp Val Ser Tyr Pro Pro Trp Asn Leu Thr Met Thr Val Phe Gln 
                245                 250                 255     


Gly Asp Ala Thr Ala Ser Thr Ala Leu Gly Asn Gly Ser Ser Leu Ser 
            260                 265                 270         


Val Leu Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asn Ser Asn 
        275                 280                 285             


Pro Pro Ala Arg Leu Ser Trp Thr Arg Gly Ser Leu Thr Leu Cys Pro 
    290                 295                 300                 


Ser Arg Ser Ser Asn Pro Gly Leu Leu Glu Leu Pro Arg Val His Val 
305                 310                 315                 320 


Arg Asp Glu Gly Glu Phe Thr Cys Arg Ala Gln Asn Ala Gln Gly Ser 
                325                 330                 335     


Gln His Ile Ser Leu Ser Leu Ser Leu Gln Asn Glu Gly Thr Gly Thr 
            340                 345                 350         


Ser Arg Pro Val Ser Gln Val Thr Leu Ala Ala Val Gly Gly Ala Gly 
        355                 360                 365             


Ala Thr Ala Leu Ala Phe Leu Ser Phe Cys Ile Ile Phe Ile Ile Val 
    370                 375                 380                 


Arg Ser Cys Arg Lys Lys Ser Ala Arg Pro Ala Ala Gly Val Gly Asp 
385                 390                 395                 400 


Thr Gly Met Glu Asp Ala Lys Ala Ile Arg Gly Ser Ala Ser Gln Gly 
                405                 410                 415     


Pro Leu Thr Glu Ser Trp Lys Asp Gly Asn Pro Leu Lys Lys Pro Pro 
            420                 425                 430         


Pro Ala Val Ala Pro Ser Ser Gly Glu Glu Gly Glu Leu His Tyr Ala 
        435                 440                 445             


Thr Leu Ser Phe His Lys Val Lys Pro Gln Asp Pro Gln Gly Gln Glu 
    450                 455                 460                 


Ala Thr Asp Ser Glu Tyr Ser Glu Ile Lys Ile His Lys Arg Glu Thr 
465                 470                 475                 480 


Ala Glu Thr Gln Ala Cys Leu Arg Asn His Asn Pro Ser Ser Lys Glu 
                485                 490                 495     


Val Arg Gly 
            


<210>  3941
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  3941

Met Val Ala Lys Gln Arg Ile Arg Met Ala Asn Glu Lys His Ser Lys 
1               5                   10                  15      


Asn Ile Thr Gln Arg Gly Asn Val Ala Lys Thr Ser Arg Asn Ala Pro 
            20                  25                  30          


Glu Glu Lys Ala Ser Val Gly Pro Trp Leu Leu Ala Leu Phe Ile Phe 
        35                  40                  45              


Val Val Cys Gly Ser Ala Ile Phe Gln Ile Ile Gln Ser Ile Arg Met 
    50                  55                  60                  


Gly Met 
65      


<210>  3942
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  3942

Met Leu Ser Thr Gly Val Val Ser Phe Phe Ser Leu Lys Ser Asp Ser 
1               5                   10                  15      


Ala Pro Pro Trp Met Val Leu Ala Val Leu Trp Cys Ser Met Ala Gln 
            20                  25                  30          


Thr Leu Leu Leu Pro Ser Phe Ile Trp Ser Cys Glu Arg Tyr Arg Ala 
        35                  40                  45              


Asp Val Arg Thr Val Trp Glu Gln Cys Val Ala Ile Met Ser Glu Glu 
    50                  55                  60                  


Asp Gly Asp Asp Asp Gly Gly Cys Asp Asp Tyr Ala Glu Gly Arg Val 
65                  70                  75                  80  


Cys Lys Val Arg Phe Asp Ala Asn Gly Ala Thr Gly Pro Gly Ser Arg 
                85                  90                  95      


Asp Pro Ala Gln Val Lys Leu Leu Pro Gly Arg His Met Leu Phe Pro 
            100                 105                 110         


Pro Leu Glu Arg Val His Tyr Leu Gln Val Pro Leu Ser Arg Arg Leu 
        115                 120                 125             


Ser His Asp Glu Thr Asn Ile Phe Ser Thr Pro Arg Glu Pro Gly Ser 
    130                 135                 140                 


Phe Leu His Lys Trp Ser Ser Ser Asp Asp Ile Arg Val Leu Pro Ala 
145                 150                 155                 160 


Gln Ser Arg Ala Leu Gly Gly Pro Pro Glu Tyr Leu Gly Gln Arg His 
                165                 170                 175     


Arg Leu Glu Asp Glu Glu Asp Glu Glu Glu Ala Glu Gly Gly Gly Leu 
            180                 185                 190         


Ala Ser Leu Arg Gln Phe Leu Glu Ser Gly Val Leu Gly Ser Gly Gly 
        195                 200                 205             


Gly Pro Pro Arg Gly Pro Gly Phe Phe Arg Glu Glu Ile Thr Thr Phe 
    210                 215                 220                 


Ile Asp Glu Thr Pro Leu Pro Ser Pro Thr Ala Ser Pro Gly His Ser 
225                 230                 235                 240 


Pro Arg Arg Pro Arg Pro Leu Gly Leu Ser Pro Arg Arg Leu Ser Leu 
                245                 250                 255     


Gly Ser Pro Glu Ser Arg Ala Val Gly Leu Pro Leu Gly Leu Ser Ala 
            260                 265                 270         


Gly Arg Arg Cys Ser Leu Thr Gly Gly Glu Glu Ser Ala Arg Ala Trp 
        275                 280                 285             


Gly Gly Ser Trp Gly Pro Gly Asn Pro Ile Phe Pro Gln Leu Thr Leu 
    290                 295                 300                 


<210>  3943
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  3943

Met Asn Gln Ala Asp Pro Arg Leu Arg Ala Val Cys Leu Trp Thr Leu 
1               5                   10                  15      


Thr Ser Ala Ala Met Ser Arg Gly Asp Asn Cys Thr Asp Leu Leu Ala 
            20                  25                  30          


Leu Gly Ile Pro Ser Ile Thr Gln Ala Trp Gly Leu Trp Val Leu Leu 
        35                  40                  45              


Gly Ala Val Thr Leu Leu Phe Leu Ile Ser Leu Ala Ala His Leu Ser 
    50                  55                  60                  


Gln Trp Thr Arg Gly Arg Ser Arg Ser His Pro Gly Gln Gly Arg Ser 
65                  70                  75                  80  


Gly Glu Ser Val Glu Glu Val Pro Leu Tyr Gly Asn Leu His Tyr Leu 
                85                  90                  95      


Gln Thr Gly Arg Leu Ser Gln Asp Pro Glu Pro Asp Gln Gln Asp Pro 
            100                 105                 110         


Thr Leu Gly Gly Pro Ala Arg Ala Ala Glu Glu Val Met Cys Tyr Thr 
        115                 120                 125             


Ser Leu Gln Leu Arg Pro Pro Gln Gly Arg Ile Pro Gly Pro Gly Thr 
    130                 135                 140                 


Pro Val Lys Tyr Ser Glu Val Val Leu Asp Ser Glu Pro Lys Ser Gln 
145                 150                 155                 160 


Ala Ser Gly Pro Glu Pro Glu Leu Tyr Ala Ser Val Cys Ala Gln Thr 
                165                 170                 175     


Arg Arg Ala Arg Ala Ser Phe Pro Asp Gln Ala Tyr Ala Asn Ser Gln 
            180                 185                 190         


Pro Ala Ala Ser 
        195     


<210>  3944
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  3944

Met Gly Thr Ser Pro Ser Ser Ser Thr Ala Leu Ala Ser Cys Ser Arg 
1               5                   10                  15      


Ile Ala Arg Arg Ala Thr Ala Thr Met Ile Ala Gly Ser Leu Leu Leu 
            20                  25                  30          


Leu Gly Phe Leu Ser Thr Thr Thr Ala Gln Pro Glu Gln Lys Ala Ser 
        35                  40                  45              


Asn Leu Ile Gly Thr Tyr Arg His Val Asp Arg Ala Thr Gly Gln Val 
    50                  55                  60                  


Leu Thr Cys Asp Lys Cys Pro Ala Gly Thr Tyr Val Ser Glu His Cys 
65                  70                  75                  80  


Thr Asn Thr Ser Leu Arg Val Cys Ser Ser Cys Pro Val Gly Thr Phe 
                85                  90                  95      


Thr Arg His Glu Asn Gly Ile Glu Lys Cys His Asp Cys Ser Gln Pro 
            100                 105                 110         


Cys Pro Trp Pro Met Ile Glu Lys Leu Pro Cys Ala Ala Leu Thr Asp 
        115                 120                 125             


Arg Glu Cys Thr Cys Pro Pro Gly Met Phe Gln Ser Asn Ala Thr Cys 
    130                 135                 140                 


Ala Pro His Thr Val Cys Pro Val Gly Trp Gly Val Arg Lys Lys Gly 
145                 150                 155                 160 


Thr Glu Thr Glu Asp Val Arg Cys Lys Gln Cys Ala Arg Gly Thr Phe 
                165                 170                 175     


Ser Asp Val Pro Ser Ser Val Met Lys Cys Lys Ala Tyr Thr Asp Cys 
            180                 185                 190         


Leu Ser Gln Asn Leu Val Val Ile Lys Pro Gly Thr Lys Glu Thr Asp 
        195                 200                 205             


Asn Val Cys Gly Thr Leu Pro Ser Phe Ser Ser Ser Thr Ser Pro Ser 
    210                 215                 220                 


Pro Gly Thr Ala Ile Phe Pro Arg Pro Glu His Met Glu Thr His Glu 
225                 230                 235                 240 


Val Pro Ser Ser Thr Tyr Val Pro Lys Gly Met Asn Ser Thr Glu Ser 
                245                 250                 255     


Asn Ser Ser Ala Ser Val Arg Pro Lys Val Leu Ser Ser Ile Gln Glu 
            260                 265                 270         


Gly Thr Val Pro Asp Asn Thr Ser Ser Ala Arg Gly Lys Glu Asp Val 
        275                 280                 285             


Asn Lys Thr Leu Pro Asn Leu Gln Val Val Asn His Gln Gln Gly Pro 
    290                 295                 300                 


His His Arg His Ile Leu Lys Leu Leu Pro Ser Met Glu Ala Thr Gly 
305                 310                 315                 320 


Gly Glu Lys Ser Ser Thr Pro Ile Lys Gly Pro Lys Arg Gly His Pro 
                325                 330                 335     


Arg Gln Asn Leu His Lys His Phe Asp Ile Asn Glu His Leu Pro Trp 
            340                 345                 350         


Met Ile Val Leu Phe Leu Leu Leu Val Leu Val Val Ile Val Val Cys 
        355                 360                 365             


Ser Ile Arg Lys Ser Ser Arg Thr Leu Lys Lys Gly Pro Arg Gln Asp 
    370                 375                 380                 


Pro Ser Ala Ile Val Glu Lys Ala Gly Leu Lys Lys Ser Met Thr Pro 
385                 390                 395                 400 


Thr Gln Asn Arg Glu Lys Trp Ile Tyr Tyr Cys Asn Gly His Gly Ile 
                405                 410                 415     


Asp Ile Leu Lys Leu Val Ala Ala Gln Val Gly Ser Gln Trp Lys Asp 
            420                 425                 430         


Ile Tyr Gln Phe Leu Cys Asn Ala Ser Glu Arg Glu Val Ala Ala Phe 
        435                 440                 445             


Ser Asn Gly Tyr Thr Ala Asp His Glu Arg Ala Tyr Ala Ala Leu Gln 
    450                 455                 460                 


His Trp Thr Ile Arg Gly Pro Glu Ala Ser Leu Ala Gln Leu Ile Ser 
465                 470                 475                 480 


Ala Leu Arg Gln His Arg Arg Asn Asp Val Val Glu Lys Ile Arg Gly 
                485                 490                 495     


Leu Met Glu Asp Thr Thr Gln Leu Glu Thr Asp Lys Leu Ala Leu Pro 
            500                 505                 510         


Met Ser Pro Ser Pro Leu Ser Pro Ser Pro Ile Pro Ser Pro Asn Ala 
        515                 520                 525             


Lys Leu Glu Asn Ser Ala Leu Leu Thr Val Glu Pro Ser Pro Gln Asp 
    530                 535                 540                 


Lys Asn Lys Gly Phe Phe Val Asp Glu Ser Glu Pro Leu Leu Arg Cys 
545                 550                 555                 560 


Asp Ser Thr Ser Ser Gly Ser Ser Ala Leu Ser Arg Asn Gly Ser Phe 
                565                 570                 575     


Ile Thr Lys Glu Lys Lys Asp Thr Val Leu Arg Gln Val Arg Leu Asp 
            580                 585                 590         


Pro Cys Asp Leu Gln Pro Ile Phe Asp Asp Met Leu His Phe Leu Asn 
        595                 600                 605             


Pro Glu Glu Leu Arg Val Ile Glu Glu Ile Pro Gln Ala Glu Asp Lys 
    610                 615                 620                 


Leu Asp Arg Leu Phe Glu Ile Ile Gly Val Lys Ser Gln Glu Ala Ser 
625                 630                 635                 640 


Gln Thr Leu Leu Asp Ser Val Tyr Ser His Leu Pro Asp Leu Leu 
                645                 650                 655 


<210>  3945
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  3945

Met Gly Ser Leu Val Leu Thr Leu Cys Ala Leu Phe Cys Leu Ala Ala 
1               5                   10                  15      


Tyr Leu Val Ser Gly Ser Pro Ile Met Asn Leu Glu Gln Ser Pro Leu 
            20                  25                  30          


Glu Glu Asp Met Ser Leu Phe Gly Asp Val Phe Ser Glu Gln Asp Gly 
        35                  40                  45              


Val Asp Phe Asn Thr Leu Leu Gln Ser Met Lys Asp Glu Phe Leu Lys 
    50                  55                  60                  


Thr Leu Asn Leu Ser Asp Ile Pro Thr Gln Asp Ser Ala Lys Val Asp 
65                  70                  75                  80  


Pro Pro Glu Tyr Met Leu Glu Leu Tyr Asn Lys Phe Ala Thr Asp Arg 
                85                  90                  95      


Thr Ser Met Pro Ser Ala Asn Ile Ile Arg Ser Phe Lys Asn Glu Asp 
            100                 105                 110         


Leu Phe Ser Gln Pro Val Ser Phe Asn Gly Leu Arg Lys Tyr Pro Leu 
        115                 120                 125             


Leu Phe Asn Val Ser Ile Pro His His Glu Glu Val Ile Met Ala Glu 
    130                 135                 140                 


Leu Arg Leu Tyr Thr Leu Val Gln Arg Asp Arg Met Ile Tyr Asp Gly 
145                 150                 155                 160 


Val Asp Arg Lys Ile Thr Ile Phe Glu Val Leu Glu Ser Lys Gly Asp 
                165                 170                 175     


Asn Glu Gly Glu Arg Asn Met Leu Val Leu Val Ser Gly Glu Ile Tyr 
            180                 185                 190         


Gly Thr Asn Ser Glu Trp Glu Thr Phe Asp Val Thr Asp Ala Ile Arg 
        195                 200                 205             


Arg Trp Gln Lys Ser Gly Ser Ser Thr His Gln Leu Glu Val His Ile 
    210                 215                 220                 


Glu Ser Lys His Asp Glu Ala Glu Asp Ala Ser Ser Gly Arg Leu Glu 
225                 230                 235                 240 


Ile Asp Thr Ser Ala Gln Asn Lys His Asn Pro Leu Leu Ile Val Phe 
                245                 250                 255     


Ser Asp Asp Gln Ser Ser Asp Lys Glu Arg Lys Glu Glu Leu Asn Glu 
            260                 265                 270         


Met Ile Ser His Glu Gln Leu Pro Glu Leu Asp Asn Leu Gly Leu Asp 
        275                 280                 285             


Ser Phe Ser Ser Gly Pro Gly Glu Glu Ala Leu Leu Gln Met Arg Ser 
    290                 295                 300                 


Asn Ile Ile Tyr Asp Ser Thr Ala Arg Ile Arg Arg Asn Ala Lys Gly 
305                 310                 315                 320 


Asn Tyr Cys Lys Arg Thr Pro Leu Tyr Ile Asp Phe Lys Glu Ile Gly 
                325                 330                 335     


Trp Asp Ser Trp Ile Ile Ala Pro Pro Gly Tyr Glu Ala Tyr Glu Cys 
            340                 345                 350         


Arg Gly Val Cys Asn Tyr Pro Leu Ala Glu His Leu Thr Pro Thr Lys 
        355                 360                 365             


His Ala Ile Ile Gln Ala Leu Val His Leu Lys Asn Ser Gln Lys Ala 
    370                 375                 380                 


Ser Lys Ala Cys Cys Val Pro Thr Lys Leu Glu Pro Ile Ser Ile Leu 
385                 390                 395                 400 


Tyr Leu Asp Lys Gly Val Val Thr Tyr Lys Phe Lys Tyr Glu Gly Met 
                405                 410                 415     


Ala Val Ser Glu Cys Gly Cys Arg 
            420                 


<210>  3946
<211>  315
<212>  PRT
<213>  Homo sapiens

<400>  3946

Met Tyr Gln Val Pro Leu Pro Leu Asp Arg Asp Gly Thr Leu Val Arg 
1               5                   10                  15      


Leu Arg Phe Thr Met Val Ala Leu Val Thr Val Cys Cys Pro Leu Val 
            20                  25                  30          


Ala Phe Leu Phe Cys Ile Leu Trp Ser Leu Leu Phe His Phe Lys Glu 
        35                  40                  45              


Thr Thr Ala Thr His Cys Gly Ala Thr Pro Cys Arg Met Phe Ser Ala 
    50                  55                  60                  


Ala Ser Gln Pro Leu Asp Pro Asp Gly Thr Leu Phe Arg Leu Arg Phe 
65                  70                  75                  80  


Thr Ala Met Val Trp Trp Ala Ile Thr Phe Pro Val Phe Gly Phe Phe 
                85                  90                  95      


Phe Cys Ile Ile Trp Ser Leu Val Phe His Phe Glu Tyr Thr Val Ala 
            100                 105                 110         


Thr Asp Cys Gly Val Pro Asn Tyr Leu Pro Ser Val Ser Ser Ala Ile 
        115                 120                 125             


Gly Gly Glu Val Pro Gln Arg Tyr Val Trp Arg Phe Cys Ile Gly Leu 
    130                 135                 140                 


His Ser Ala Pro Arg Phe Leu Val Ala Phe Ala Tyr Trp Asn His Tyr 
145                 150                 155                 160 


Leu Ser Cys Thr Ser Pro Cys Ser Cys Tyr Arg Pro Leu Cys Arg Leu 
                165                 170                 175     


Asn Phe Gly Leu Asn Val Val Glu Asn Leu Ala Leu Leu Val Leu Thr 
            180                 185                 190         


Tyr Val Ser Ser Ser Glu Asp Phe Thr Ile His Glu Asn Ala Phe Ile 
        195                 200                 205             


Val Phe Ile Ala Ser Ser Leu Gly His Met Leu Leu Thr Cys Ile Leu 
    210                 215                 220                 


Trp Arg Leu Thr Lys Lys His Thr Val Ser Gln Glu Asp Arg Lys Ser 
225                 230                 235                 240 


Tyr Ser Trp Lys Gln Arg Leu Phe Ile Ile Asn Phe Ile Ser Phe Phe 
                245                 250                 255     


Ser Ala Leu Ala Val Tyr Phe Arg His Asn Met Tyr Cys Glu Ala Gly 
            260                 265                 270         


Val Tyr Thr Ile Phe Ala Ile Leu Glu Tyr Thr Val Val Leu Thr Asn 
        275                 280                 285             


Met Ala Phe His Met Thr Ala Trp Trp Asp Phe Gly Asn Lys Glu Leu 
    290                 295                 300                 


Leu Ile Thr Ser Gln Pro Glu Glu Lys Arg Phe 
305                 310                 315 


<210>  3947
<211>  696
<212>  PRT
<213>  Homo sapiens

<400>  3947

Met Gly Asn Gly Met Cys Ser Arg Lys Gln Lys Arg Ile Phe Gln Thr 
1               5                   10                  15      


Leu Leu Leu Leu Thr Val Val Phe Gly Phe Leu Tyr Gly Ala Met Leu 
            20                  25                  30          


Tyr Tyr Glu Leu Gln Thr Gln Leu Arg Lys Ala Glu Ala Val Ala Leu 
        35                  40                  45              


Lys Tyr Gln Gln His Gln Glu Ser Leu Ser Ala Gln Leu Gln Val Val 
    50                  55                  60                  


Tyr Glu His Arg Ser Arg Leu Glu Lys Ser Leu Gln Lys Glu Arg Leu 
65                  70                  75                  80  


Glu His Lys Lys Ala Lys Glu Asp Phe Leu Val Tyr Lys Leu Glu Ala 
                85                  90                  95      


Gln Glu Thr Leu Asn Lys Gly Arg Gln Asp Ser Asn Ser Arg Tyr Ser 
            100                 105                 110         


Ala Leu Asn Val Gln His Gln Met Leu Lys Ser Gln His Glu Glu Leu 
        115                 120                 125             


Lys Lys Gln His Ser Asp Leu Glu Glu Glu His Arg Lys Gln Gly Glu 
    130                 135                 140                 


Asp Phe Ser Arg Thr Phe Asn Asp His Lys Gln Lys Tyr Leu Gln Leu 
145                 150                 155                 160 


Gln Gln Glu Lys Glu Gln Glu Leu Ser Lys Leu Lys Glu Thr Val Tyr 
                165                 170                 175     


Asn Leu Arg Glu Glu Asn Arg Gln Leu Arg Lys Ala His Gln Asp Ile 
            180                 185                 190         


His Thr Gln Leu Gln Asp Val Lys Gln Gln His Lys Asn Leu Leu Ser 
        195                 200                 205             


Glu His Glu Gln Leu Val Val Thr Leu Glu Asp His Lys Ser Ala Leu 
    210                 215                 220                 


Ala Ala Ala Gln Thr Gln Val Ala Glu Tyr Lys Gln Leu Lys Asp Thr 
225                 230                 235                 240 


Leu Asn Arg Ile Pro Ser Leu Arg Lys Pro Asp Pro Ala Glu Gln Gln 
                245                 250                 255     


Asn Val Thr Gln Val Ala His Ser Pro Gln Gly Tyr Asn Thr Ala Arg 
            260                 265                 270         


Glu Lys Pro Thr Arg Glu Val Gln Glu Val Ser Arg Asn Asn Asp Val 
        275                 280                 285             


Trp Gln Asn His Glu Ala Val Pro Gly Arg Ala Glu Asp Thr Lys Leu 
    290                 295                 300                 


Tyr Ala Pro Thr His Lys Glu Ala Glu Phe Gln Ala Pro Pro Glu Pro 
305                 310                 315                 320 


Ile Gln Gln Glu Val Glu Arg Arg Glu Pro Glu Glu His Gln Val Glu 
                325                 330                 335     


Glu Glu His Arg Lys Ala Leu Glu Glu Glu Glu Met Glu Gln Val Gly 
            340                 345                 350         


Gln Ala Glu His Leu Glu Glu Glu His Asp Pro Ser Pro Glu Glu Gln 
        355                 360                 365             


Asp Arg Glu Trp Lys Glu Gln His Glu Gln Arg Glu Ala Ala Asn Leu 
    370                 375                 380                 


Leu Glu Gly His Ala Arg Ala Glu Val Tyr Pro Ser Ala Lys Pro Met 
385                 390                 395                 400 


Ile Lys Phe Gln Ser Pro Tyr Glu Glu Gln Leu Glu Gln Gln Arg Leu 
                405                 410                 415     


Ala Val Gln Gln Val Glu Glu Ala Gln Gln Leu Arg Glu His Gln Glu 
            420                 425                 430         


Ala Leu His Gln Gln Arg Leu Gln Gly His Leu Leu Arg Gln Gln Glu 
        435                 440                 445             


Gln Gln Gln Gln Gln Val Ala Arg Glu Met Ala Leu Gln Arg Gln Ala 
    450                 455                 460                 


Glu Leu Glu Glu Gly Arg Pro Gln His Gln Glu Gln Leu Arg Gln Gln 
465                 470                 475                 480 


Ala His Tyr Asp Ala Met Asp Asn Asp Ile Val Gln Gly Ala Glu Asp 
                485                 490                 495     


Gln Gly Ile Gln Gly Glu Glu Gly Ala Tyr Glu Arg Asp Asn Gln His 
            500                 505                 510         


Gln Asp Glu Ala Glu Gly Asp Pro Gly Asn Arg His Glu Pro Arg Glu 
        515                 520                 525             


Gln Gly Pro Arg Glu Ala Asp Pro Glu Ser Glu Ala Asp Arg Ala Ala 
    530                 535                 540                 


Val Glu Asp Ile Asn Pro Ala Asp Asp Pro Asn Asn Gln Gly Glu Asp 
545                 550                 555                 560 


Glu Phe Glu Glu Ala Glu Gln Val Arg Glu Glu Asn Leu Pro Asp Glu 
                565                 570                 575     


Asn Glu Glu Gln Lys Gln Ser Asn Gln Lys Gln Glu Asn Thr Glu Val 
            580                 585                 590         


Glu Glu His Leu Val Met Ala Gly Asn Pro Asp Gln Gln Glu Asp Asn 
        595                 600                 605             


Val Asp Glu Gln Tyr Gln Glu Glu Ala Glu Glu Glu Val Gln Glu Asp 
    610                 615                 620                 


Leu Thr Glu Glu Lys Lys Arg Glu Leu Glu His Asn Ala Glu Glu Thr 
625                 630                 635                 640 


Tyr Gly Glu Asn Asp Glu Asn Thr Asp Asp Lys Asn Asn Asp Gly Glu 
                645                 650                 655     


Glu Gln Glu Val Arg Asp Asp Asn Arg Pro Lys Gly Arg Glu Glu His 
            660                 665                 670         


Tyr Glu Glu Glu Glu Glu Glu Glu Glu Asp Gly Ala Ala Val Ala Glu 
        675                 680                 685             


Lys Ser His Arg Arg Ala Glu Met 
    690                 695     


<210>  3948
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  3948

Met Ala Asn Leu Asp Lys Tyr Thr Glu Thr Phe Lys Met Gly Ser Asn 
1               5                   10                  15      


Ser Thr Ser Thr Ala Glu Ile Tyr Cys Asn Val Thr Asn Val Lys Phe 
            20                  25                  30          


Gln Tyr Ser Leu Tyr Ala Thr Thr Tyr Ile Leu Ile Phe Ile Pro Gly 
        35                  40                  45              


Leu Leu Ala Asn Ser Ala Ala Leu Trp Val Leu Cys Arg Phe Ile Ser 
    50                  55                  60                  


Lys Lys Asn Lys Ala Ile Ile Phe Met Ile Asn Leu Ser Val Ala Asp 
65                  70                  75                  80  


Leu Ala His Val Leu Ser Leu Pro Leu Arg Ile Tyr Tyr Tyr Ile Ser 
                85                  90                  95      


His His Trp Pro Phe Gln Arg Ala Leu Cys Leu Leu Cys Phe Tyr Leu 
            100                 105                 110         


Lys Tyr Leu Asn Met Tyr Ala Ser Ile Cys Phe Leu Thr Cys Ile Ser 
        115                 120                 125             


Leu Gln Arg Cys Phe Phe Leu Leu Lys Pro Phe Arg Ala Arg Asp Trp 
    130                 135                 140                 


Lys Arg Arg Tyr Asp Val Gly Ile Ser Ala Ala Ile Trp Ile Val Val 
145                 150                 155                 160 


Gly Thr Ala Cys Leu Pro Phe Pro Ile Leu Arg Ser Thr Asp Leu Asn 
                165                 170                 175     


Asn Asn Lys Ser Cys Phe Ala Asp Leu Gly Tyr Lys Gln Met Asn Ala 
            180                 185                 190         


Val Ala Leu Val Gly Met Ile Thr Val Ala Glu Leu Ala Gly Phe Val 
        195                 200                 205             


Ile Pro Val Ile Ile Ile Ala Trp Cys Thr Trp Lys Thr Thr Ile Ser 
    210                 215                 220                 


Leu Arg Gln Pro Pro Met Ala Phe Gln Gly Ile Ser Glu Arg Gln Lys 
225                 230                 235                 240 


Ala Leu Arg Met Val Phe Met Cys Ala Ala Val Phe Phe Ile Cys Phe 
                245                 250                 255     


Thr Pro Tyr His Ile Asn Phe Ile Phe Tyr Thr Met Val Lys Glu Thr 
            260                 265                 270         


Ile Ile Ser Ser Cys Pro Val Val Arg Ile Ala Leu Tyr Phe His Pro 
        275                 280                 285             


Phe Cys Leu Cys Leu Ala Ser Leu Cys Cys Leu Leu Asp Pro Ile Leu 
    290                 295                 300                 


Tyr Tyr Phe Met Ala Ser Glu Phe Arg Asp Gln Leu Ser Arg His Gly 
305                 310                 315                 320 


Ser Ser Val Thr Arg Ser Arg Leu Met Ser Lys Glu Ser Gly Ser Ser 
                325                 330                 335     


Met Ile Gly 
            


<210>  3949
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  3949

Met Ala Lys Leu Arg Val Ala Tyr Glu Tyr Thr Glu Ala Glu Asp Lys 
1               5                   10                  15      


Ser Ile Arg Leu Gly Leu Phe Leu Ile Ile Ser Gly Val Val Ser Leu 
            20                  25                  30          


Phe Ile Phe Gly Phe Cys Trp Leu Ser Pro Ala Leu Gln Asp Leu Gln 
        35                  40                  45              


Ala Thr Glu Ala Asn Cys Thr Val Leu Ser Val Gln Gln Ile Gly Glu 
    50                  55                  60                  


Val Phe Glu Cys Thr Phe Thr Cys Gly Ala Asp Cys Arg Gly Thr Ser 
65                  70                  75                  80  


Gln Tyr Pro Cys Val Gln Val Tyr Val Asn Asn Ser Glu Ser Asn Ser 
                85                  90                  95      


Arg Ala Leu Leu His Ser Asp Glu His Gln Leu Leu Thr Asn Pro Lys 
            100                 105                 110         


Cys Ser Tyr Ile Pro Pro Cys Lys Arg Glu Asn Gln Lys Asn Leu Glu 
        115                 120                 125             


Ser Val Met Asn Trp Gln Gln Tyr Trp Lys Asp Glu Ile Gly Ser Gln 
    130                 135                 140                 


Pro Phe Thr Cys Tyr Phe Asn Gln His Gln Arg Pro Asp Asp Val Leu 
145                 150                 155                 160 


Leu His Arg Thr His Asp Glu Ile Val Leu Leu His Cys Phe Leu Trp 
                165                 170                 175     


Pro Leu Val Thr Phe Val Val Gly Val Leu Ile Val Val Leu Thr Ile 
            180                 185                 190         


Cys Ala Lys Ser Leu Ala Val Lys Ala Glu Ala Met Lys Lys Arg Lys 
        195                 200                 205             


Phe Ser 
    210 


<210>  3950
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  3950

Met Leu Arg Ala Gly Trp Leu Arg Gly Ala Ala Ala Leu Ala Leu Leu 
1               5                   10                  15      


Leu Ala Ala Arg Val Val Ala Ala Phe Glu Pro Ile Thr Val Gly Leu 
            20                  25                  30          


Ala Ile Gly Ala Ala Ser Ala Ile Thr Gly Tyr Leu Ser Tyr Asn Asp 
        35                  40                  45              


Ile Tyr Cys Arg Phe Ala Glu Cys Cys Arg Glu Glu Arg Pro Leu Asn 
    50                  55                  60                  


Ala Ser Ala Leu Lys Leu Asp Leu Glu Glu Lys Leu Phe Gly Gln His 
65                  70                  75                  80  


Leu Ala Thr Glu Val Ile Phe Lys Ala Leu Thr Gly Phe Arg Asn Asn 
                85                  90                  95      


Lys Asn Pro Lys Lys Pro Leu Thr Leu Ser Leu His Gly Trp Ala Gly 
            100                 105                 110         


Thr Gly Lys Asn Phe Val Ser Gln Ile Val Ala Glu Asn Leu His Pro 
        115                 120                 125             


Lys Gly Leu Lys Ser Asn Phe Val His Leu Phe Val Ser Thr Leu His 
    130                 135                 140                 


Phe Pro His Glu Gln Lys Ile Lys Leu Tyr Gln Asp Gln Leu Gln Lys 
145                 150                 155                 160 


Trp Ile Arg Gly Asn Val Ser Ala Cys Ala Asn Ser Val Phe Ile Phe 
                165                 170                 175     


Asp Glu Met Asp Lys Leu His Pro Gly Ile Ile Asp Ala Ile Lys Pro 
            180                 185                 190         


Phe Leu Asp Tyr Tyr Glu Gln Val Asp Gly Val Ser Tyr Arg Lys Ala 
        195                 200                 205             


Ile Phe Ile Phe Leu Ser Asn Ala Gly Gly Asp Leu Ile Thr Lys Thr 
    210                 215                 220                 


Ala Leu Asp Phe Trp Arg Ala Gly Arg Lys Arg Glu Asp Ile Gln Leu 
225                 230                 235                 240 


Lys Asp Leu Glu Pro Val Leu Ser Val Gly Val Phe Asn Asn Lys His 
                245                 250                 255     


Ser Gly Leu Trp His Ser Gly Leu Ile Asp Lys Asn Leu Ile Asp Tyr 
            260                 265                 270         


Phe Ile Pro Phe Leu Pro Leu Glu Tyr Arg His Val Lys Met Cys Val 
        275                 280                 285             


Arg Ala Glu Met Arg Ala Arg Gly Ser Ala Ile Asp Glu Asp Ile Val 
    290                 295                 300                 


Thr Arg Val Ala Glu Glu Met Thr Phe Phe Pro Arg Asp Glu Lys Ile 
305                 310                 315                 320 


Tyr Ser Asp Lys Gly Cys Lys Thr Val Gln Ser Arg Leu Asp Phe His 
                325                 330                 335     


<210>  3951
<211>  4935
<212>  PRT
<213>  Homo sapiens

<400>  3951

Met Gly Asn Glu Ala Ser Leu Glu Gly Glu Gly Leu Pro Glu Gly Leu 
1               5                   10                  15      


Ala Ala Ala Ala Ala Ala Gly Gly Gly Ala Ser Gly Ala Gly Ser Pro 
            20                  25                  30          


Ser His Thr Ala Ile Pro Ala Gly Met Glu Ala Asp Leu Ser Gln Leu 
        35                  40                  45              


Ser Glu Glu Glu Arg Arg Gln Ile Ala Ala Val Met Ser Arg Ala Gln 
    50                  55                  60                  


Gly Leu Pro Lys Gly Ser Val Pro Pro Ala Ala Ala Glu Ser Pro Ser 
65                  70                  75                  80  


Met His Arg Lys Gln Glu Leu Asp Ser Ser His Pro Pro Lys Gln Ser 
                85                  90                  95      


Gly Arg Pro Pro Asp Pro Gly Arg Pro Ala Gln Pro Gly Leu Ser Lys 
            100                 105                 110         


Ser Arg Thr Thr Asp Thr Phe Arg Ser Glu Gln Lys Leu Pro Gly Arg 
        115                 120                 125             


Ser Pro Ser Thr Ile Ser Leu Lys Glu Ser Lys Ser Arg Thr Asp Leu 
    130                 135                 140                 


Lys Glu Glu His Lys Ser Ser Met Met Pro Gly Phe Leu Ser Glu Val 
145                 150                 155                 160 


Asn Ala Leu Ser Ala Val Ser Ser Val Val Asn Lys Phe Asn Pro Phe 
                165                 170                 175     


Asp Leu Ile Ser Asp Ser Glu Ala Ser Gln Glu Glu Thr Thr Lys Lys 
            180                 185                 190         


Gln Lys Val Val Gln Lys Glu Gln Gly Lys Pro Glu Gly Ile Ile Lys 
        195                 200                 205             


Pro Pro Leu Gln Gln Gln Pro Pro Lys Pro Ile Pro Lys Gln Gln Gly 
    210                 215                 220                 


Pro Gly Arg Asp Pro Leu Gln Gln Asp Gly Thr Pro Lys Ser Ile Ser 
225                 230                 235                 240 


Ser Gln Gln Pro Glu Lys Ile Lys Ser Gln Pro Pro Gly Thr Gly Lys 
                245                 250                 255     


Pro Ile Gln Gly Pro Thr Gln Thr Pro Gln Thr Asp His Ala Lys Leu 
            260                 265                 270         


Pro Leu Gln Arg Asp Ala Ser Arg Pro Gln Thr Lys Gln Ala Asp Ile 
        275                 280                 285             


Val Arg Gly Glu Ser Val Lys Pro Ser Leu Pro Ser Pro Ser Lys Pro 
    290                 295                 300                 


Pro Ile Gln Gln Pro Thr Pro Gly Lys Pro Pro Ala Gln Gln Pro Gly 
305                 310                 315                 320 


His Glu Lys Ser Gln Pro Gly Pro Ala Lys Pro Pro Ala Gln Pro Ser 
                325                 330                 335     


Gly Leu Thr Lys Pro Leu Ala Gln Gln Pro Gly Thr Val Lys Pro Pro 
            340                 345                 350         


Val Gln Pro Pro Gly Thr Thr Lys Pro Pro Ala Gln Pro Leu Gly Pro 
        355                 360                 365             


Ala Lys Pro Pro Ala Gln Gln Thr Gly Ser Glu Lys Pro Ser Ser Glu 
    370                 375                 380                 


Gln Pro Gly Pro Lys Ala Leu Ala Gln Pro Pro Gly Val Gly Lys Thr 
385                 390                 395                 400 


Pro Ala Gln Gln Pro Gly Pro Ala Lys Pro Pro Thr Gln Gln Val Gly 
                405                 410                 415     


Thr Pro Lys Pro Leu Ala Gln Gln Pro Gly Leu Gln Ser Pro Ala Lys 
            420                 425                 430         


Ala Pro Gly Pro Thr Lys Thr Pro Val Gln Gln Pro Gly Pro Gly Lys 
        435                 440                 445             


Ile Pro Ala Gln Gln Ala Gly Pro Gly Lys Thr Ser Ala Gln Gln Thr 
    450                 455                 460                 


Gly Pro Thr Lys Pro Pro Ser Gln Leu Pro Gly Pro Ala Lys Pro Pro 
465                 470                 475                 480 


Pro Gln Gln Pro Gly Pro Ala Lys Pro Pro Pro Gln Gln Pro Gly Ser 
                485                 490                 495     


Ala Lys Pro Pro Ser Gln Gln Pro Gly Ser Thr Lys Pro Pro Pro Gln 
            500                 505                 510         


Gln Pro Gly Pro Ala Lys Pro Ser Pro Gln Gln Pro Gly Ser Thr Lys 
        515                 520                 525             


Pro Pro Ser Gln Gln Pro Gly Ser Ala Lys Pro Ser Ala Gln Gln Pro 
    530                 535                 540                 


Ser Pro Ala Lys Pro Ser Ala Gln Gln Ser Thr Lys Pro Val Ser Gln 
545                 550                 555                 560 


Thr Gly Ser Gly Lys Pro Leu Gln Pro Pro Thr Val Ser Pro Ser Ala 
                565                 570                 575     


Lys Gln Pro Pro Ser Gln Gly Leu Pro Lys Thr Ile Cys Pro Leu Cys 
            580                 585                 590         


Asn Thr Thr Glu Leu Leu Leu His Val Pro Glu Lys Ala Asn Phe Asn 
        595                 600                 605             


Thr Cys Thr Glu Cys Gln Thr Thr Val Cys Ser Leu Cys Gly Phe Asn 
    610                 615                 620                 


Pro Asn Pro His Leu Thr Glu Val Lys Glu Trp Leu Cys Leu Asn Cys 
625                 630                 635                 640 


Gln Met Lys Arg Ala Leu Gly Gly Asp Leu Ala Pro Val Pro Ser Ser 
                645                 650                 655     


Pro Gln Pro Lys Leu Lys Thr Ala Pro Val Thr Thr Thr Ser Ala Val 
            660                 665                 670         


Ser Lys Ser Ser Pro Gln Pro Gln Gln Thr Ser Pro Lys Lys Asp Ala 
        675                 680                 685             


Ala Pro Lys Gln Asp Leu Ser Lys Ala Pro Glu Pro Lys Lys Pro Pro 
    690                 695                 700                 


Pro Leu Val Lys Gln Pro Thr Leu His Gly Ser Pro Ser Ala Lys Ala 
705                 710                 715                 720 


Lys Gln Pro Pro Glu Ala Asp Ser Leu Ser Lys Pro Ala Pro Pro Lys 
                725                 730                 735     


Glu Pro Ser Val Pro Ser Glu Gln Asp Lys Ala Pro Val Ala Asp Asp 
            740                 745                 750         


Lys Pro Lys Gln Pro Lys Met Val Lys Pro Thr Thr Asp Leu Val Ser 
        755                 760                 765             


Ser Ser Ser Ala Thr Thr Lys Pro Asp Ile Pro Ser Ser Lys Val Gln 
    770                 775                 780                 


Ser Gln Ala Glu Glu Lys Thr Thr Pro Pro Leu Lys Thr Asp Ser Ala 
785                 790                 795                 800 


Lys Pro Ser Gln Ser Phe Pro Pro Thr Gly Glu Lys Val Ser Pro Phe 
                805                 810                 815     


Asp Ser Lys Ala Ile Pro Arg Pro Ala Ser Asp Ser Lys Ile Ile Ser 
            820                 825                 830         


His Pro Gly Pro Ser Ser Glu Ser Lys Gly Gln Lys Gln Val Asp Pro 
        835                 840                 845             


Val Gln Lys Lys Glu Glu Pro Lys Lys Ala Gln Thr Lys Met Ser Pro 
    850                 855                 860                 


Lys Pro Asp Ala Lys Pro Met Pro Lys Gly Ser Pro Thr Pro Pro Gly 
865                 870                 875                 880 


Pro Arg Pro Thr Ala Gly Gln Thr Val Pro Thr Pro Gln Gln Ser Pro 
                885                 890                 895     


Lys Pro Gln Glu Gln Ser Arg Arg Phe Ser Leu Asn Leu Gly Ser Ile 
            900                 905                 910         


Thr Asp Ala Pro Lys Ser Gln Pro Thr Thr Pro Gln Glu Thr Val Thr 
        915                 920                 925             


Gly Lys Leu Phe Gly Phe Gly Ala Ser Ile Phe Ser Gln Ala Ser Asn 
    930                 935                 940                 


Leu Ile Ser Thr Ala Gly Gln Pro Gly Pro His Ser Gln Ser Gly Pro 
945                 950                 955                 960 


Gly Ala Pro Met Lys Gln Ala Pro Ala Pro Ser Gln Pro Pro Thr Ser 
                965                 970                 975     


Gln Gly Pro Pro Lys Ser Thr Gly Gln Ala Pro Pro Ala Pro Ala Lys 
            980                 985                 990         


Ser Ile Pro Val Lys Lys Glu Thr  Lys Ala Pro Ala Ala  Glu Lys Leu 
        995                 1000                 1005             


Glu Pro  Lys Ala Glu Gln Ala  Pro Thr Val Lys Arg  Thr Glu Thr 
    1010                 1015                 1020             


Glu Lys  Lys Pro Pro Pro Ile  Lys Asp Ser Lys Ser  Leu Thr Ala 
    1025                 1030                 1035             


Glu Pro  Gln Lys Ala Val Leu  Pro Thr Lys Leu Glu  Lys Ser Pro 
    1040                 1045                 1050             


Lys Pro  Glu Ser Thr Cys Pro  Leu Cys Lys Thr Glu  Leu Asn Ile 
    1055                 1060                 1065             


Gly Ser  Lys Asp Pro Pro Asn  Phe Asn Thr Cys Thr  Glu Cys Lys 
    1070                 1075                 1080             


Asn Gln  Val Cys Asn Leu Cys  Gly Phe Asn Pro Thr  Pro His Leu 
    1085                 1090                 1095             


Thr Glu  Ile Gln Glu Trp Leu  Cys Leu Asn Cys Gln  Thr Gln Arg 
    1100                 1105                 1110             


Ala Ile  Ser Gly Gln Leu Gly  Asp Ile Arg Lys Met  Pro Pro Ala 
    1115                 1120                 1125             


Pro Ser  Gly Pro Lys Ala Ser  Pro Met Pro Val Pro  Thr Glu Ser 
    1130                 1135                 1140             


Ser Ser  Gln Lys Thr Ala Val  Pro Pro Gln Val Lys  Leu Val Lys 
    1145                 1150                 1155             


Lys Gln  Glu Gln Glu Val Lys  Thr Glu Ala Glu Lys  Val Ile Leu 
    1160                 1165                 1170             


Glu Lys  Val Lys Glu Thr Leu  Ser Met Glu Lys Ile  Pro Pro Met 
    1175                 1180                 1185             


Val Thr  Thr Asp Gln Lys Gln  Glu Glu Ser Lys Leu  Glu Lys Asp 
    1190                 1195                 1200             


Lys Ala  Ser Ala Leu Gln Glu  Lys Lys Pro Leu Pro  Glu Glu Lys 
    1205                 1210                 1215             


Lys Leu  Ile Pro Glu Glu Glu  Lys Ile Arg Ser Glu  Glu Lys Lys 
    1220                 1225                 1230             


Pro Leu  Leu Glu Glu Lys Lys  Pro Thr Pro Glu Asp  Lys Lys Leu 
    1235                 1240                 1245             


Leu Pro  Glu Ala Lys Thr Ser  Ala Pro Glu Glu Gln  Lys His Asp 
    1250                 1255                 1260             


Leu Leu  Lys Ser Gln Val Gln  Ile Ala Glu Glu Lys  Leu Glu Gly 
    1265                 1270                 1275             


Arg Val  Ala Pro Lys Thr Val  Gln Glu Gly Lys Gln  Pro Gln Thr 
    1280                 1285                 1290             


Lys Met  Glu Gly Leu Pro Ser  Gly Thr Pro Gln Ser  Leu Pro Lys 
    1295                 1300                 1305             


Glu Asp  Asp Lys Thr Thr Lys  Thr Ile Lys Glu Gln  Pro Gln Pro 
    1310                 1315                 1320             


Pro Cys  Thr Ala Lys Pro Asp  Gln Val Glu Pro Gly  Lys Glu Lys 
    1325                 1330                 1335             


Thr Glu  Lys Glu Asp Asp Lys  Ser Asp Thr Ser Ser  Ser Gln Gln 
    1340                 1345                 1350             


Pro Lys  Ser Pro Gln Gly Leu  Ser Asp Thr Gly Tyr  Ser Ser Asp 
    1355                 1360                 1365             


Gly Ile  Ser Ser Ser Leu Gly  Glu Ile Pro Ser Leu  Ile Pro Thr 
    1370                 1375                 1380             


Asp Glu  Lys Asp Ile Leu Lys  Gly Leu Lys Lys Asp  Ser Phe Ser 
    1385                 1390                 1395             


Gln Glu  Ser Ser Pro Ser Ser  Pro Ser Asp Leu Ala  Lys Leu Glu 
    1400                 1405                 1410             


Ser Thr  Val Leu Ser Ile Leu  Glu Ala Gln Ala Ser  Thr Leu Ala 
    1415                 1420                 1425             


Asp Glu  Lys Ser Glu Lys Lys  Thr Gln Pro His Glu  Val Ser Pro 
    1430                 1435                 1440             


Glu Gln  Pro Lys Asp Gln Glu  Lys Thr Gln Ser Leu  Ser Glu Thr 
    1445                 1450                 1455             


Leu Glu  Ile Thr Ile Ser Glu  Glu Glu Ile Lys Glu  Ser Gln Glu 
    1460                 1465                 1470             


Glu Arg  Lys Asp Thr Phe Lys  Lys Asp Ser Gln Gln  Asp Ile Pro 
    1475                 1480                 1485             


Ser Ser  Lys Asp His Lys Glu  Lys Ser Glu Phe Val  Asp Asp Ile 
    1490                 1495                 1500             


Thr Thr  Arg Arg Glu Pro Tyr  Asp Ser Val Glu Glu  Ser Ser Glu 
    1505                 1510                 1515             


Ser Glu  Asn Ser Pro Val Pro  Gln Arg Lys Arg Arg  Thr Ser Val 
    1520                 1525                 1530             


Gly Ser  Ser Ser Ser Asp Glu  Tyr Lys Gln Glu Asp  Ser Gln Gly 
    1535                 1540                 1545             


Ser Gly  Glu Glu Glu Asp Phe  Ile Arg Lys Gln Ile  Ile Glu Met 
    1550                 1555                 1560             


Ser Ala  Asp Glu Asp Ala Ser  Gly Ser Glu Asp Asp  Glu Phe Ile 
    1565                 1570                 1575             


Arg Asn  Gln Leu Lys Glu Ile  Ser Ser Ser Thr Glu  Ser Gln Lys 
    1580                 1585                 1590             


Lys Glu  Glu Thr Lys Gly Lys  Gly Lys Ile Thr Ala  Gly Lys His 
    1595                 1600                 1605             


Arg Arg  Leu Thr Arg Lys Ser  Ser Thr Ser Ile Asp  Glu Asp Ala 
    1610                 1615                 1620             


Gly Arg  Arg His Ser Trp His  Asp Glu Asp Asp Glu  Ala Phe Asp 
    1625                 1630                 1635             


Glu Ser  Pro Glu Leu Lys Tyr  Arg Glu Thr Lys Ser  Gln Glu Ser 
    1640                 1645                 1650             


Glu Glu  Leu Val Val Thr Gly  Gly Gly Gly Leu Arg  Arg Phe Lys 
    1655                 1660                 1665             


Thr Ile  Glu Leu Asn Ser Thr  Ile Ala Asp Lys Tyr  Ser Ala Glu 
    1670                 1675                 1680             


Ser Ser  Gln Lys Lys Thr Ser  Leu Tyr Phe Asp Glu  Glu Pro Glu 
    1685                 1690                 1695             


Leu Glu  Met Glu Ser Leu Thr  Asp Ser Pro Glu Asp  Arg Ser Arg 
    1700                 1705                 1710             


Gly Glu  Gly Ser Ser Ser Leu  His Ala Ser Ser Phe  Thr Pro Gly 
    1715                 1720                 1725             


Thr Ser  Pro Thr Ser Val Ser  Ser Leu Asp Glu Asp  Ser Asp Ser 
    1730                 1735                 1740             


Ser Pro  Ser His Lys Lys Gly  Glu Ser Lys Gln Gln  Arg Lys Ala 
    1745                 1750                 1755             


Arg His  Arg Pro His Gly Pro  Leu Leu Pro Thr Ile  Glu Asp Ser 
    1760                 1765                 1770             


Ser Glu  Glu Glu Glu Leu Arg  Glu Glu Glu Glu Leu  Leu Lys Glu 
    1775                 1780                 1785             


Gln Glu  Lys Gln Arg Glu Ile  Glu Gln Gln Gln Arg  Lys Ser Ser 
    1790                 1795                 1800             


Ser Lys  Lys Ser Lys Lys Asp  Lys Asp Glu Leu Arg  Ala Gln Arg 
    1805                 1810                 1815             


Arg Arg  Glu Arg Pro Lys Thr  Pro Pro Ser Asn Leu  Ser Pro Ile 
    1820                 1825                 1830             


Glu Asp  Ala Ser Pro Thr Glu  Glu Leu Arg Gln Ala  Ala Glu Met 
    1835                 1840                 1845             


Glu Glu  Leu His Arg Ser Ser  Cys Ser Glu Tyr Ser  Pro Ser Ile 
    1850                 1855                 1860             


Glu Ser  Asp Pro Glu Gly Phe  Glu Ile Ser Pro Glu  Lys Ile Ile 
    1865                 1870                 1875             


Glu Val  Gln Lys Val Tyr Lys  Leu Pro Thr Ala Val  Ser Leu Tyr 
    1880                 1885                 1890             


Ser Pro  Thr Asp Glu Gln Ser  Ile Met Gln Lys Glu  Gly Ser Gln 
    1895                 1900                 1905             


Lys Ala  Leu Lys Ser Ala Glu  Glu Met Tyr Glu Glu  Met Met His 
    1910                 1915                 1920             


Lys Thr  His Lys Tyr Lys Ala  Phe Pro Ala Ala Asn  Glu Arg Asp 
    1925                 1930                 1935             


Glu Val  Phe Glu Lys Glu Pro  Leu Tyr Gly Gly Met  Leu Ile Glu 
    1940                 1945                 1950             


Asp Tyr  Ile Tyr Glu Ser Leu  Val Glu Asp Thr Tyr  Asn Gly Ser 
    1955                 1960                 1965             


Val Asp  Gly Ser Leu Leu Thr  Arg Gln Glu Glu Glu  Asn Gly Phe 
    1970                 1975                 1980             


Met Gln  Gln Lys Gly Arg Glu  Gln Lys Ile Arg Leu  Ser Glu Gln 
    1985                 1990                 1995             


Ile Tyr  Glu Asp Pro Met Gln  Lys Ile Thr Asp Leu  Gln Lys Glu 
    2000                 2005                 2010             


Phe Tyr  Glu Leu Glu Ser Leu  His Ser Val Val Pro  Gln Glu Asp 
    2015                 2020                 2025             


Ile Val  Ser Ser Ser Phe Ile  Ile Pro Glu Ser His  Glu Ile Val 
    2030                 2035                 2040             


Asp Leu  Gly Thr Met Val Thr  Ser Thr Glu Glu Glu  Arg Lys Leu 
    2045                 2050                 2055             


Leu Asp  Ala Asp Ala Ala Tyr  Glu Glu Leu Met Lys  Arg Gln Gln 
    2060                 2065                 2070             


Met Gln  Leu Thr Pro Gly Ser  Ser Pro Thr Gln Ala  Pro Ile Gly 
    2075                 2080                 2085             


Glu Asp  Met Thr Glu Ser Thr  Met Asp Phe Asp Arg  Met Pro Asp 
    2090                 2095                 2100             


Ala Ser  Leu Thr Ser Ser Val  Leu Ser Gly Ala Ser  Leu Thr Asp 
    2105                 2110                 2115             


Ser Thr  Ser Ser Ala Thr Leu  Ser Ile Pro Asp Val  Lys Ile Thr 
    2120                 2125                 2130             


Gln His  Phe Ser Thr Glu Glu  Ile Glu Asp Glu Tyr  Val Thr Asp 
    2135                 2140                 2145             


Tyr Thr  Arg Glu Ile Gln Glu  Ile Ile Ala His Glu  Ser Leu Ile 
    2150                 2155                 2160             


Leu Thr  Tyr Ser Glu Pro Ser  Glu Ser Ala Thr Ser  Val Pro Pro 
    2165                 2170                 2175             


Ser Asp  Thr Pro Ser Leu Thr  Ser Ser Val Ser Ser  Val Cys Thr 
    2180                 2185                 2190             


Thr Asp  Ser Ser Ser Pro Ile  Thr Thr Leu Asp Ser  Ile Thr Thr 
    2195                 2200                 2205             


Val Tyr  Thr Glu Pro Val Asp  Met Ile Thr Lys Phe  Glu Asp Ser 
    2210                 2215                 2220             


Glu Glu  Ile Ser Ser Ser Thr  Tyr Phe Pro Gly Ser  Ile Ile Asp 
    2225                 2230                 2235             


Tyr Pro  Glu Glu Ile Ser Val  Ser Leu Asp Arg Thr  Ala Pro Pro 
    2240                 2245                 2250             


Asp Gly  Arg Ala Ser Ala Asp  His Ile Val Ile Ser  Leu Ser Asp 
    2255                 2260                 2265             


Met Ala  Ser Ser Ile Ile Glu  Ser Val Val Pro Lys  Pro Glu Gly 
    2270                 2275                 2280             


Pro Val  Ala Asp Thr Val Ser  Thr Asp Leu Leu Ile  Ser Glu Lys 
    2285                 2290                 2295             


Asp Pro  Val Lys Lys Ala Lys  Lys Glu Thr Gly Asn  Gly Ile Ile 
    2300                 2305                 2310             


Leu Glu  Val Leu Glu Ala Tyr  Arg Asp Lys Lys Glu  Leu Glu Ala 
    2315                 2320                 2325             


Glu Arg  Thr Lys Ser Ser Leu  Ser Glu Thr Val Phe  Asp His Pro 
    2330                 2335                 2340             


Pro Ser  Ser Val Ile Ala Leu  Pro Met Lys Glu Gln  Leu Ser Thr 
    2345                 2350                 2355             


Thr Tyr  Phe Thr Ser Gly Glu  Thr Phe Gly Gln Glu  Lys Pro Ala 
    2360                 2365                 2370             


Ser Gln  Leu Pro Ser Gly Ser  Pro Ser Val Ser Ser  Leu Pro Ala 
    2375                 2380                 2385             


Lys Pro  Arg Pro Phe Phe Arg  Ser Ser Ser Leu Asp  Ile Ser Ala 
    2390                 2395                 2400             


Gln Pro  Pro Pro Pro Pro Pro  Pro Pro Pro Pro Pro  Pro Pro Pro 
    2405                 2410                 2415             


Pro Pro  Pro Pro Pro Pro Pro  Pro Leu Pro Pro Pro  Thr Ser Pro 
    2420                 2425                 2430             


Lys Pro  Thr Ile Leu Pro Lys  Lys Lys Leu Thr Val  Ala Ser Pro 
    2435                 2440                 2445             


Val Thr  Thr Ala Thr Pro Leu  Phe Asp Ala Val Thr  Thr Leu Glu 
    2450                 2455                 2460             


Thr Thr  Ala Val Leu Arg Ser  Asn Gly Leu Pro Val  Thr Arg Ile 
    2465                 2470                 2475             


Cys Thr  Thr Ala Pro Pro Pro  Val Pro Pro Lys Pro  Ser Ser Ile 
    2480                 2485                 2490             


Pro Ser  Gly Leu Val Phe Thr  His Arg Pro Glu Pro  Ser Lys Pro 
    2495                 2500                 2505             


Pro Ile  Ala Pro Lys Pro Val  Ile Pro Gln Leu Pro  Thr Thr Thr 
    2510                 2515                 2520             


Gln Lys  Pro Thr Asp Ile His  Pro Lys Pro Thr Gly  Leu Ser Leu 
    2525                 2530                 2535             


Thr Ser  Ser Met Thr Leu Asn  Leu Val Thr Ser Ala  Asp Tyr Lys 
    2540                 2545                 2550             


Leu Pro  Ser Pro Thr Ser Pro  Leu Ser Pro His Ser  Asn Lys Ser 
    2555                 2560                 2565             


Ser Pro  Arg Phe Ser Lys Ser  Leu Thr Glu Thr Tyr  Val Val Ile 
    2570                 2575                 2580             


Thr Leu  Pro Ser Glu Pro Gly  Thr Pro Thr Asp Ser  Ser Ala Ser 
    2585                 2590                 2595             


Gln Ala  Ile Thr Ser Trp Pro  Leu Gly Ser Pro Ser  Lys Asp Leu 
    2600                 2605                 2610             


Val Ser  Val Glu Pro Val Phe  Ser Val Val Pro Pro  Val Thr Ala 
    2615                 2620                 2625             


Val Glu  Ile Pro Ile Ser Ser  Glu Gln Thr Phe Tyr  Ile Ser Gly 
    2630                 2635                 2640             


Ala Leu  Gln Thr Phe Ser Ala  Thr Pro Val Thr Ala  Pro Ser Ser 
    2645                 2650                 2655             


Phe Gln  Ala Ala Pro Thr Ser  Val Thr Gln Phe Leu  Thr Thr Glu 
    2660                 2665                 2670             


Val Ser  Lys Thr Glu Val Ser  Ala Thr Arg Ser Thr  Ala Pro Ser 
    2675                 2680                 2685             


Val Gly  Leu Ser Ser Ile Ser  Ile Thr Ile Pro Pro  Glu Pro Leu 
    2690                 2695                 2700             


Ala Leu  Asp Asn Ile His Leu  Glu Lys Pro Gln Tyr  Lys Glu Asp 
    2705                 2710                 2715             


Gly Lys  Leu Gln Leu Val Gly  Asp Val Ile Asp Leu  Arg Thr Val 
    2720                 2725                 2730             


Pro Lys  Val Glu Val Lys Thr  Thr Asp Lys Cys Ile  Asp Leu Ser 
    2735                 2740                 2745             


Ala Ser  Thr Met Asp Val Lys  Arg Gln Ile Thr Ala  Asn Glu Val 
    2750                 2755                 2760             


Tyr Gly  Lys Gln Ile Ser Ala  Val Gln Pro Ser Ile  Ile Asn Leu 
    2765                 2770                 2775             


Ser Val  Thr Ser Ser Ile Val  Thr Pro Val Ser Leu  Ala Thr Glu 
    2780                 2785                 2790             


Thr Val  Thr Phe Val Thr Cys  Thr Ala Ser Ala Ser  Tyr Thr Thr 
    2795                 2800                 2805             


Gly Thr  Glu Ser Leu Val Gly  Ala Glu His Ala Met  Thr Thr Pro 
    2810                 2815                 2820             


Leu Gln  Leu Thr Thr Ser Lys  His Ala Glu Pro Pro  Tyr Arg Ile 
    2825                 2830                 2835             


Pro Ser  Asp Gln Val Phe Pro  Ile Ala Arg Glu Glu  Ala Pro Ile 
    2840                 2845                 2850             


Asn Leu  Ser Leu Gly Thr Pro  Ala His Ala Val Thr  Leu Ala Ile 
    2855                 2860                 2865             


Thr Lys  Pro Val Thr Val Pro  Pro Val Gly Val Thr  Asn Gly Trp 
    2870                 2875                 2880             


Thr Asp  Ser Thr Val Ser Gln  Gly Ile Thr Asp Gly  Glu Val Val 
    2885                 2890                 2895             


Asp Leu  Ser Thr Thr Lys Ser  His Arg Thr Val Val  Thr Met Asp 
    2900                 2905                 2910             


Glu Ser  Thr Ser Ser Val Met  Thr Lys Ile Ile Glu  Asp Glu Lys 
    2915                 2920                 2925             


Pro Val  Asp Leu Thr Ala Gly  Arg Arg Ala Val Cys  Cys Asp Val 
    2930                 2935                 2940             


Val Tyr  Lys Leu Pro Phe Gly  Arg Ser Cys Thr Ala  Gln Gln Pro 
    2945                 2950                 2955             


Ala Thr  Thr Leu Pro Glu Asp  Arg Phe Gly Tyr Arg  Asp Asp His 
    2960                 2965                 2970             


Tyr Gln  Tyr Asp Arg Ser Gly  Pro Tyr Gly Tyr Arg  Gly Ile Gly 
    2975                 2980                 2985             


Gly Met  Lys Pro Ser Met Ser  Asp Thr Asn Leu Ala  Glu Ala Gly 
    2990                 2995                 3000             


His Phe  Phe Tyr Lys Ser Lys  Asn Ala Phe Asp Tyr  Ser Glu Gly 
    3005                 3010                 3015             


Thr Asp  Thr Ala Val Asp Leu  Thr Ser Gly Arg Val  Thr Thr Gly 
    3020                 3025                 3030             


Glu Val  Met Asp Tyr Ser Ser  Lys Thr Thr Gly Pro  Tyr Pro Glu 
    3035                 3040                 3045             


Thr Arg  Gln Val Ile Ser Gly  Ala Gly Ile Ser Thr  Pro Gln Tyr 
    3050                 3055                 3060             


Ser Thr  Ala Arg Met Thr Pro  Pro Pro Gly Pro Gln  Tyr Cys Val 
    3065                 3070                 3075             


Gly Ser  Val Leu Arg Ser Ser  Asn Gly Val Val Tyr  Ser Ser Val 
    3080                 3085                 3090             


Ala Thr  Pro Thr Pro Ser Thr  Phe Ala Ile Thr Thr  Gln Pro Gly 
    3095                 3100                 3105             


Ser Ile  Phe Ser Thr Thr Val  Arg Asp Leu Ser Gly  Ile His Thr 
    3110                 3115                 3120             


Ala Asp  Ala Val Thr Ser Leu  Pro Ala Met His His  Ser Gln Pro 
    3125                 3130                 3135             


Met Pro  Arg Ser Tyr Phe Ile  Thr Thr Gly Ala Ser  Glu Thr Asp 
    3140                 3145                 3150             


Ile Ala  Val Thr Gly Ile Asp  Ile Ser Ala Ser Leu  Gln Thr Ile 
    3155                 3160                 3165             


Thr Met  Glu Ser Leu Thr Ala  Glu Thr Ile Asp Ser  Val Pro Thr 
    3170                 3175                 3180             


Leu Thr  Thr Ala Ser Glu Val  Phe Pro Glu Val Val  Gly Asp Glu 
    3185                 3190                 3195             


Ser Ala  Leu Leu Ile Val Pro  Glu Glu Asp Lys Gln  Gln Gln Gln 
    3200                 3205                 3210             


Leu Asp  Leu Glu Arg Glu Leu  Leu Glu Leu Glu Lys  Ile Lys Gln 
    3215                 3220                 3225             


Gln Arg  Phe Ala Glu Glu Leu  Glu Trp Glu Arg Gln  Glu Ile Gln 
    3230                 3235                 3240             


Arg Phe  Arg Glu Gln Glu Lys  Ile Met Val Gln Lys  Lys Leu Glu 
    3245                 3250                 3255             


Glu Leu  Gln Ser Met Lys Gln  His Leu Leu Phe Gln  Gln Glu Glu 
    3260                 3265                 3270             


Glu Arg  Gln Ala Gln Phe Met  Met Arg Gln Glu Thr  Leu Ala Gln 
    3275                 3280                 3285             


Gln Gln  Leu Gln Leu Glu Gln  Ile Gln Gln Leu Gln  Gln Gln Leu 
    3290                 3295                 3300             


His Gln  Gln Leu Glu Glu Gln  Lys Ile Arg Gln Ile  Tyr Gln Tyr 
    3305                 3310                 3315             


Asn Tyr  Asp Pro Ser Gly Thr  Ala Ser Pro Gln Thr  Thr Thr Glu 
    3320                 3325                 3330             


Gln Ala  Ile Leu Glu Gly Gln  Tyr Ala Ala Leu Glu  Gly Ser Gln 
    3335                 3340                 3345             


Phe Trp  Ala Thr Glu Asp Ala  Thr Thr Thr Ala Ser  Ala Val Val 
    3350                 3355                 3360             


Ala Ile  Glu Ile Pro Gln Ser  Gln Gly Trp Tyr Thr  Val Gln Ser 
    3365                 3370                 3375             


Asp Gly  Val Thr Gln Tyr Ile  Ala Pro Pro Gly Ile  Leu Ser Thr 
    3380                 3385                 3390             


Val Ser  Glu Ile Pro Leu Thr  Asp Val Val Val Lys  Glu Glu Lys 
    3395                 3400                 3405             


Gln Pro  Lys Lys Arg Ser Ser  Gly Ala Lys Val Arg  Gly Gln Tyr 
    3410                 3415                 3420             


Asp Asp  Met Gly Glu Asn Met  Thr Asp Asp Pro Arg  Ser Phe Lys 
    3425                 3430                 3435             


Lys Ile  Val Asp Ser Gly Val  Gln Thr Asp Asp Glu  Asp Ala Thr 
    3440                 3445                 3450             


Asp Arg  Ser Tyr Val Ser Arg  Arg Arg Arg Thr Lys  Lys Ser Val 
    3455                 3460                 3465             


Asp Thr  Ser Val Gln Thr Asp  Asp Glu Asp Gln Asp  Glu Trp Asp 
    3470                 3475                 3480             


Met Pro  Thr Arg Ser Arg Arg  Lys Ala Arg Val Gly  Lys Tyr Gly 
    3485                 3490                 3495             


Asp Ser  Met Thr Glu Ala Asp  Lys Thr Lys Pro Leu  Ser Lys Val 
    3500                 3505                 3510             


Ser Ser  Ile Ala Val Gln Thr  Val Ala Glu Ile Ser  Val Gln Thr 
    3515                 3520                 3525             


Glu Pro  Val Gly Thr Ile Arg  Thr Pro Ser Ile Arg  Ala Arg Val 
    3530                 3535                 3540             


Asp Ala  Lys Val Glu Ile Ile  Lys His Ile Ser Ala  Pro Glu Lys 
    3545                 3550                 3555             


Thr Tyr  Lys Gly Gly Ser Leu  Gly Cys Gln Thr Glu  Ala Asp Ser 
    3560                 3565                 3570             


Asp Thr  Gln Ser Pro Gln Tyr  Leu Ser Ala Thr Ser  Pro Pro Lys 
    3575                 3580                 3585             


Asp Lys  Lys Arg Pro Thr Pro  Leu Glu Ile Gly Tyr  Ser Ser His 
    3590                 3595                 3600             


Leu Arg  Ala Asp Ser Thr Val  Gln Leu Ala Pro Ser  Pro Pro Lys 
    3605                 3610                 3615             


Ser Pro  Lys Val Leu Tyr Ser  Pro Ile Ser Pro Leu  Ser Pro Gly 
    3620                 3625                 3630             


Lys Ala  Leu Glu Ser Ala Phe  Val Pro Tyr Glu Lys  Pro Leu Pro 
    3635                 3640                 3645             


Asp Asp  Ile Ser Pro Gln Lys  Val Leu His Pro Asp  Met Ala Lys 
    3650                 3655                 3660             


Val Pro  Pro Ala Ser Pro Lys  Thr Ala Lys Met Met  Gln Arg Ser 
    3665                 3670                 3675             


Met Ser  Asp Pro Lys Pro Leu  Ser Pro Thr Ala Asp  Glu Ser Ser 
    3680                 3685                 3690             


Arg Ala  Pro Phe Gln Tyr Thr  Glu Gly Tyr Thr Thr  Lys Gly Ser 
    3695                 3700                 3705             


Gln Thr  Met Thr Ser Ser Gly  Ala Gln Lys Lys Val  Lys Arg Thr 
    3710                 3715                 3720             


Leu Pro  Asn Pro Pro Pro Glu  Glu Ile Ser Thr Gly  Thr Gln Ser 
    3725                 3730                 3735             


Thr Phe  Ser Thr Met Gly Thr  Val Ser Arg Arg Arg  Ile Cys Arg 
    3740                 3745                 3750             


Thr Asn  Thr Met Ala Arg Ala  Lys Ile Leu Gln Asp  Ile Asp Arg 
    3755                 3760                 3765             


Glu Leu  Asp Leu Val Glu Arg  Glu Ser Ala Lys Leu  Arg Lys Lys 
    3770                 3775                 3780             


Gln Ala  Glu Leu Asp Glu Glu  Glu Lys Glu Ile Asp  Ala Lys Leu 
    3785                 3790                 3795             


Arg Tyr  Leu Glu Met Gly Ile  Asn Arg Arg Lys Glu  Ala Leu Leu 
    3800                 3805                 3810             


Lys Glu  Arg Glu Lys Arg Glu  Arg Ala Tyr Leu Gln  Gly Val Ala 
    3815                 3820                 3825             


Glu Asp  Arg Asp Tyr Met Ser  Asp Ser Glu Val Ser  Ser Thr Arg 
    3830                 3835                 3840             


Pro Thr  Arg Ile Glu Ser Gln  His Gly Ile Glu Arg  Pro Arg Thr 
    3845                 3850                 3855             


Ala Pro  Gln Thr Glu Phe Ser  Gln Phe Ile Pro Pro  Gln Thr Gln 
    3860                 3865                 3870             


Thr Glu  Ser Gln Leu Val Pro  Pro Thr Ser Pro Tyr  Thr Gln Tyr 
    3875                 3880                 3885             


Gln Tyr  Ser Ser Pro Ala Leu  Pro Thr Gln Ala Pro  Thr Ser Tyr 
    3890                 3895                 3900             


Thr Gln  Gln Ser His Phe Glu  Gln Gln Thr Leu Tyr  His Gln Gln 
    3905                 3910                 3915             


Val Ser  Pro Tyr Gln Thr Gln  Pro Thr Phe Gln Ala  Val Ala Thr 
    3920                 3925                 3930             


Met Ser  Phe Thr Pro Gln Val  Gln Pro Thr Pro Thr  Pro Gln Pro 
    3935                 3940                 3945             


Ser Tyr  Gln Leu Pro Ser Gln  Met Met Val Ile Gln  Gln Lys Pro 
    3950                 3955                 3960             


Arg Gln  Thr Thr Leu Tyr Leu  Glu Pro Lys Ile Thr  Ser Asn Tyr 
    3965                 3970                 3975             


Glu Val  Ile Arg Asn Gln Pro  Leu Met Ile Ala Pro  Val Ser Thr 
    3980                 3985                 3990             


Asp Asn  Thr Phe Ala Val Ser  His Leu Gly Ser Lys  Tyr Asn Ser 
    3995                 4000                 4005             


Leu Asp  Leu Arg Ile Gly Leu  Glu Glu Arg Ser Ser  Met Ala Ser 
    4010                 4015                 4020             


Ser Pro  Ile Ser Ser Ile Ser  Ala Asp Ser Phe Tyr  Ala Asp Ile 
    4025                 4030                 4035             


Asp His  His Thr Pro Arg Asn  Tyr Val Leu Ile Asp  Asp Ile Gly 
    4040                 4045                 4050             


Glu Ile  Thr Lys Gly Thr Ala  Ala Leu Ser Thr Ala  Phe Ser Leu 
    4055                 4060                 4065             


His Glu  Lys Asp Leu Ser Lys  Thr Asp Arg Leu Leu  Arg Thr Thr 
    4070                 4075                 4080             


Glu Thr  Arg Arg Ser Gln Glu  Val Thr Asp Phe Leu  Ala Pro Leu 
    4085                 4090                 4095             


Gln Ser  Ser Ser Arg Leu His  Ser Tyr Val Lys Ala  Glu Glu Asp 
    4100                 4105                 4110             


Pro Met  Glu Asp Pro Tyr Glu  Leu Lys Leu Leu Lys  His Gln Ile 
    4115                 4120                 4125             


Lys Gln  Glu Phe Arg Arg Gly  Thr Glu Ser Leu Asp  His Leu Ala 
    4130                 4135                 4140             


Gly Leu  Ser His Tyr Tyr His  Ala Asp Thr Ser Tyr  Arg His Phe 
    4145                 4150                 4155             


Pro Lys  Ser Glu Lys Tyr Ser  Ile Ser Arg Leu Thr  Leu Glu Lys 
    4160                 4165                 4170             


Gln Ala  Ala Lys Gln Leu Pro  Ala Ala Ile Leu Tyr  Gln Lys Gln 
    4175                 4180                 4185             


Ser Lys  His Lys Lys Ser Leu  Ile Asp Pro Lys Met  Ser Lys Phe 
    4190                 4195                 4200             


Ser Pro  Ile Gln Glu Ser Arg  Asp Leu Glu Pro Asp  Tyr Ser Ser 
    4205                 4210                 4215             


Tyr Met  Thr Ser Ser Thr Ser  Ser Ile Gly Gly Ile  Ser Ser Arg 
    4220                 4225                 4230             


Ala Arg  Leu Leu Gln Asp Asp  Ile Thr Phe Gly Leu  Arg Lys Asn 
    4235                 4240                 4245             


Ile Thr  Asp Gln Gln Lys Phe  Met Gly Ser Ser Leu  Gly Thr Gly 
    4250                 4255                 4260             


Leu Gly  Thr Leu Gly Asn Thr  Ile Arg Ser Ala Leu  Gln Asp Glu 
    4265                 4270                 4275             


Ala Asp  Lys Pro Tyr Ser Ser  Gly Ser Arg Ser Arg  Pro Ser Ser 
    4280                 4285                 4290             


Arg Pro  Ser Ser Val Tyr Gly  Leu Asp Leu Ser Ile  Lys Arg Asp 
    4295                 4300                 4305             


Ser Ser  Ser Ser Ser Leu Arg  Leu Lys Ala Gln Glu  Ala Glu Ala 
    4310                 4315                 4320             


Leu Asp  Val Ser Phe Ser His  Ala Ser Ser Ser Ala  Arg Thr Lys 
    4325                 4330                 4335             


Pro Thr  Ser Leu Pro Ile Ser  Gln Ser Arg Gly Arg  Ile Pro Ile 
    4340                 4345                 4350             


Val Ala  Gln Asn Ser Glu Glu  Glu Ser Pro Leu Ser  Pro Val Gly 
    4355                 4360                 4365             


Gln Pro  Met Gly Met Ala Arg  Ala Ala Ala Gly Pro  Leu Pro Pro 
    4370                 4375                 4380             


Ile Ser  Ala Asp Thr Arg Asp  Gln Phe Gly Ser Ser  His Ser Leu 
    4385                 4390                 4395             


Pro Glu  Val Gln Gln His Met  Arg Glu Glu Ser Arg  Thr Arg Gly 
    4400                 4405                 4410             


Tyr Asp  Arg Asp Ile Ala Phe  Ile Met Asp Asp Phe  Gln His Ala 
    4415                 4420                 4425             


Met Ser  Asp Ser Glu Ala Tyr  His Leu Arg Arg Glu  Glu Thr Asp 
    4430                 4435                 4440             


Trp Phe  Asp Lys Pro Arg Glu  Ser Arg Leu Glu Asn  Gly His Gly 
    4445                 4450                 4455             


Leu Asp  Arg Lys Leu Pro Glu  Arg Leu Val His Ser  Arg Pro Leu 
    4460                 4465                 4470             


Ser Gln  His Gln Glu Gln Ile  Ile Gln Met Asn Gly  Lys Thr Met 
    4475                 4480                 4485             


His Tyr  Ile Phe Pro His Ala  Arg Ile Lys Ile Thr  Arg Asp Ser 
    4490                 4495                 4500             


Lys Asp  His Thr Val Ser Gly  Asn Gly Leu Gly Ile  Arg Ile Val 
    4505                 4510                 4515             


Gly Gly  Lys Glu Ile Pro Gly  His Ser Gly Glu Ile  Gly Ala Tyr 
    4520                 4525                 4530             


Ile Ala  Lys Ile Leu Pro Gly  Gly Ser Ala Glu Gln  Thr Gly Lys 
    4535                 4540                 4545             


Leu Met  Glu Gly Met Gln Val  Leu Glu Trp Asn Gly  Ile Pro Leu 
    4550                 4555                 4560             


Thr Ser  Lys Thr Tyr Glu Glu  Val Gln Ser Ile Ile  Ser Gln Gln 
    4565                 4570                 4575             


Ser Gly  Glu Ala Glu Ile Cys  Val Arg Leu Asp Leu  Asn Met Leu 
    4580                 4585                 4590             


Ser Asp  Ser Glu Asn Ser Gln  His Leu Glu Leu His  Glu Pro Pro 
    4595                 4600                 4605             


Lys Ala  Val Asp Lys Ala Lys  Ser Pro Gly Val Asp  Pro Lys Gln 
    4610                 4615                 4620             


Leu Ala  Ala Glu Leu Gln Lys  Val Ser Leu Gln Gln  Ser Pro Leu 
    4625                 4630                 4635             


Val Leu  Ser Ser Val Val Glu  Lys Gly Ser His Val  His Ser Gly 
    4640                 4645                 4650             


Pro Thr  Ser Ala Gly Ser Ser  Ser Val Pro Ser Pro  Gly Gln Pro 
    4655                 4660                 4665             


Gly Ser  Pro Ser Val Ser Lys  Lys Lys His Gly Ser  Ser Lys Pro 
    4670                 4675                 4680             


Thr Asp  Gly Thr Lys Val Val  Ser His Pro Ile Thr  Gly Glu Ile 
    4685                 4690                 4695             


Gln Leu  Gln Ile Asn Tyr Asp  Leu Gly Asn Leu Ile  Ile His Ile 
    4700                 4705                 4710             


Leu Gln  Ala Arg Asn Leu Val  Pro Arg Asp Asn Asn  Gly Tyr Ser 
    4715                 4720                 4725             


Asp Pro  Phe Val Lys Val Tyr  Leu Leu Pro Gly Arg  Gly Gln Val 
    4730                 4735                 4740             


Met Val  Val Gln Asn Ala Ser  Ala Glu Tyr Lys Arg  Arg Thr Lys 
    4745                 4750                 4755             


His Val  Gln Lys Ser Leu Asn  Pro Glu Trp Asn Gln  Thr Val Ile 
    4760                 4765                 4770             


Tyr Lys  Ser Ile Ser Met Glu  Gln Leu Lys Lys Lys  Thr Leu Glu 
    4775                 4780                 4785             


Val Thr  Val Trp Asp Tyr Asp  Arg Phe Ser Ser Asn  Asp Phe Leu 
    4790                 4795                 4800             


Gly Glu  Val Leu Ile Asp Leu  Ser Ser Thr Ser His  Leu Asp Asn 
    4805                 4810                 4815             


Thr Pro  Arg Trp Tyr Pro Leu  Lys Glu Gln Thr Glu  Ser Ile Asp 
    4820                 4825                 4830             


His Gly  Lys Ser His Ser Ser  Gln Ser Ser Gln Gln  Ser Pro Lys 
    4835                 4840                 4845             


Pro Ser  Val Ile Lys Ser Arg  Ser His Gly Ile Phe  Pro Asp Pro 
    4850                 4855                 4860             


Ser Lys  Asp Met Gln Val Pro  Thr Ile Glu Lys Ser  His Ser Ser 
    4865                 4870                 4875             


Pro Gly  Ser Ser Lys Ser Ser  Ser Glu Gly His Leu  Arg Ser His 
    4880                 4885                 4890             


Gly Pro  Ser Arg Ser Gln Ser  Lys Thr Ser Val Thr  Gln Thr His 
    4895                 4900                 4905             


Leu Glu  Asp Ala Gly Ala Ala  Ile Ala Ala Ala Glu  Ala Ala Val 
    4910                 4915                 4920             


Gln Gln  Leu Arg Ile Gln Pro  Ser Lys Arg Arg Lys  
    4925                 4930                 4935 


<210>  3952
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  3952

Met Ser Leu Met Val Val Ser Met Val Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro His Glu Gly Val His Arg Lys Pro Ser Leu Leu 
            20                  25                  30          


Ala His Pro Gly Pro Leu Val Lys Ser Glu Glu Thr Val Ile Leu Gln 
        35                  40                  45              


Cys Trp Ser Asp Val Arg Phe Gln His Phe Leu Leu His Arg Glu Gly 
    50                  55                  60                  


Lys Phe Lys Asp Thr Leu His Leu Ile Gly Glu His His Asp Gly Val 
65                  70                  75                  80  


Ser Lys Ala Asn Phe Ser Ile Gly Pro Met Met Gln Asp Leu Ala Gly 
                85                  90                  95      


Thr Tyr Arg Cys Tyr Gly Ser Val Thr His Ser Pro Tyr Gln Leu Ser 
            100                 105                 110         


Ala Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys 
        115                 120                 125             


Pro Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Leu Ala Gly Glu Ser 
    130                 135                 140                 


Val Thr Leu Ser Cys Ser Ser Arg Ser Ser Tyr Asp Met Tyr His Leu 
145                 150                 155                 160 


Ser Arg Glu Gly Glu Ala His Glu Arg Arg Phe Ser Ala Gly Pro Lys 
                165                 170                 175     


Val Asn Gly Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His 
            180                 185                 190         


Gly Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Asp Ser Pro Tyr Glu 
        195                 200                 205             


Trp Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro 
    210                 215                 220                 


Ser Asn Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Glu Thr Gly Asn 
225                 230                 235                 240 


Pro Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Ile Ile Leu 
                245                 250                 255     


Phe Ile Leu Leu Leu Phe Phe Leu Leu His Arg Trp Cys Cys Asn Lys 
            260                 265                 270         


Lys Asn Ala Val Val Met Asp Gln Glu Pro Ala Gly Asn Arg Thr Val 
        275                 280                 285             


Asn Arg Glu Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala 
    290                 295                 300                 


Gln Leu Asn His Cys Val Phe Thr Gln Arg Lys Ile Thr Arg Pro Ser 
305                 310                 315                 320 


Gln Arg Pro Lys Thr Pro Pro Thr Asp Ile Ile Val Tyr Thr Glu Leu 
                325                 330                 335     


Pro Asn Ala Glu Pro 
            340     


<210>  3953
<211>  1339
<212>  PRT
<213>  Homo sapiens

<400>  3953

Met Asp Leu Leu Ser Gly Thr Tyr Ile Phe Ala Val Leu Leu Ala Cys 
1               5                   10                  15      


Val Val Phe His Ser Gly Ala Gln Glu Lys Asn Tyr Thr Ile Arg Glu 
            20                  25                  30          


Glu Met Pro Glu Asn Val Leu Ile Gly Asp Leu Leu Lys Asp Leu Asn 
        35                  40                  45              


Leu Ser Leu Ile Pro Asn Lys Ser Leu Thr Thr Ala Met Gln Phe Lys 
    50                  55                  60                  


Leu Val Tyr Lys Thr Gly Asp Val Pro Leu Ile Arg Ile Glu Glu Asp 
65                  70                  75                  80  


Thr Gly Glu Ile Phe Thr Thr Gly Ala Arg Ile Asp Arg Glu Lys Leu 
                85                  90                  95      


Cys Ala Gly Ile Pro Arg Asp Glu His Cys Phe Tyr Glu Val Glu Val 
            100                 105                 110         


Ala Ile Leu Pro Asp Glu Ile Phe Arg Leu Val Lys Ile Arg Phe Leu 
        115                 120                 125             


Ile Glu Asp Ile Asn Asp Asn Ala Pro Leu Phe Pro Ala Thr Val Ile 
    130                 135                 140                 


Asn Ile Ser Ile Pro Glu Asn Ser Ala Ile Asn Ser Lys Tyr Thr Leu 
145                 150                 155                 160 


Pro Ala Ala Val Asp Pro Asp Val Gly Ile Asn Gly Val Gln Asn Tyr 
                165                 170                 175     


Glu Leu Ile Lys Ser Gln Asn Ile Phe Gly Leu Asp Val Ile Glu Thr 
            180                 185                 190         


Pro Glu Gly Asp Lys Met Pro Gln Leu Ile Val Gln Lys Glu Leu Asp 
        195                 200                 205             


Arg Glu Glu Lys Asp Thr Tyr Val Met Lys Val Lys Val Glu Asp Gly 
    210                 215                 220                 


Gly Phe Pro Gln Arg Ser Ser Thr Ala Ile Leu Gln Val Ser Val Thr 
225                 230                 235                 240 


Asp Thr Asn Asp Asn His Pro Val Phe Lys Glu Thr Glu Ile Glu Val 
                245                 250                 255     


Ser Ile Pro Glu Asn Ala Pro Val Gly Thr Ser Val Thr Gln Leu His 
            260                 265                 270         


Ala Thr Asp Ala Asp Ile Gly Glu Asn Ala Lys Ile His Phe Ser Phe 
        275                 280                 285             


Ser Asn Leu Val Ser Asn Ile Ala Arg Arg Leu Phe His Leu Asn Ala 
    290                 295                 300                 


Thr Thr Gly Leu Ile Thr Ile Lys Glu Pro Leu Asp Arg Glu Glu Thr 
305                 310                 315                 320 


Pro Asn His Lys Leu Leu Val Leu Ala Ser Asp Gly Gly Leu Met Pro 
                325                 330                 335     


Ala Arg Ala Met Val Leu Val Asn Val Thr Asp Val Asn Asp Asn Val 
            340                 345                 350         


Pro Ser Ile Asp Ile Arg Tyr Ile Val Asn Pro Val Asn Asp Thr Val 
        355                 360                 365             


Val Leu Ser Glu Asn Ile Pro Leu Asn Thr Lys Ile Ala Leu Ile Thr 
    370                 375                 380                 


Val Thr Asp Lys Asp Ala Asp His Asn Gly Arg Val Thr Cys Phe Thr 
385                 390                 395                 400 


Asp His Glu Ile Pro Phe Arg Leu Arg Pro Val Phe Ser Asn Gln Phe 
                405                 410                 415     


Leu Leu Glu Thr Ala Ala Tyr Leu Asp Tyr Glu Ser Thr Lys Glu Tyr 
            420                 425                 430         


Ala Ile Lys Leu Leu Ala Ala Asp Ala Gly Lys Pro Pro Leu Asn Gln 
        435                 440                 445             


Ser Ala Met Leu Phe Ile Lys Val Lys Asp Glu Asn Asp Asn Ala Pro 
    450                 455                 460                 


Val Phe Thr Gln Ser Phe Val Thr Val Ser Ile Pro Glu Asn Asn Ser 
465                 470                 475                 480 


Pro Gly Ile Gln Leu Thr Lys Val Ser Ala Met Asp Ala Asp Ser Gly 
                485                 490                 495     


Pro Asn Ala Lys Ile Asn Tyr Leu Leu Gly Pro Asp Ala Pro Pro Glu 
            500                 505                 510         


Phe Ser Leu Asp Cys Arg Thr Gly Met Leu Thr Val Val Lys Lys Leu 
        515                 520                 525             


Asp Arg Glu Lys Glu Asp Lys Tyr Leu Phe Thr Ile Leu Ala Lys Asp 
    530                 535                 540                 


Asn Gly Val Pro Pro Leu Thr Ser Asn Val Thr Val Phe Val Ser Ile 
545                 550                 555                 560 


Ile Asp Gln Asn Asp Asn Ser Pro Val Phe Thr His Asn Glu Tyr Asn 
                565                 570                 575     


Phe Tyr Val Pro Glu Asn Leu Pro Arg His Gly Thr Val Gly Leu Ile 
            580                 585                 590         


Thr Val Thr Asp Pro Asp Tyr Gly Asp Asn Ser Ala Val Thr Leu Ser 
        595                 600                 605             


Ile Leu Asp Glu Asn Asp Asp Phe Thr Ile Asp Ser Gln Thr Gly Val 
    610                 615                 620                 


Ile Arg Pro Asn Ile Ser Phe Asp Arg Glu Lys Gln Glu Ser Tyr Thr 
625                 630                 635                 640 


Phe Tyr Val Lys Ala Glu Asp Gly Gly Arg Val Ser Arg Ser Ser Ser 
                645                 650                 655     


Ala Lys Val Thr Ile Asn Val Val Asp Val Asn Asp Asn Lys Pro Val 
            660                 665                 670         


Phe Ile Val Pro Pro Ser Asn Cys Ser Tyr Glu Leu Val Leu Pro Ser 
        675                 680                 685             


Thr Asn Pro Gly Thr Val Val Phe Gln Val Ile Ala Val Asp Asn Asp 
    690                 695                 700                 


Thr Gly Met Asn Ala Glu Val Arg Tyr Ser Ile Val Gly Gly Asn Thr 
705                 710                 715                 720 


Arg Asp Leu Phe Ala Ile Asp Gln Glu Thr Gly Asn Ile Thr Leu Met 
                725                 730                 735     


Glu Lys Cys Asp Val Thr Asp Leu Gly Leu His Arg Val Leu Val Lys 
            740                 745                 750         


Ala Asn Asp Leu Gly Gln Pro Asp Ser Leu Phe Ser Val Val Ile Val 
        755                 760                 765             


Asn Leu Phe Val Asn Glu Ser Val Thr Asn Ala Thr Leu Ile Asn Glu 
    770                 775                 780                 


Leu Val Arg Lys Ser Thr Glu Ala Pro Val Thr Pro Asn Thr Glu Ile 
785                 790                 795                 800 


Ala Asp Val Ser Ser Pro Thr Ser Asp Tyr Val Lys Ile Leu Val Ala 
                805                 810                 815     


Ala Val Ala Gly Thr Ile Thr Val Val Val Val Ile Phe Ile Thr Ala 
            820                 825                 830         


Val Val Arg Cys Arg Gln Ala Pro His Leu Lys Ala Ala Gln Lys Asn 
        835                 840                 845             


Lys Gln Asn Ser Glu Trp Ala Thr Pro Asn Pro Glu Asn Arg Gln Met 
    850                 855                 860                 


Ile Met Met Lys Lys Lys Lys Lys Lys Lys Lys His Ser Pro Lys Asn 
865                 870                 875                 880 


Leu Leu Leu Asn Phe Val Thr Ile Glu Glu Thr Lys Ala Asp Asp Val 
                885                 890                 895     


Asp Ser Asp Gly Asn Arg Val Thr Leu Asp Leu Pro Ile Asp Leu Glu 
            900                 905                 910         


Glu Gln Thr Met Gly Lys Tyr Asn Trp Val Thr Thr Pro Thr Thr Phe 
        915                 920                 925             


Lys Pro Asp Ser Pro Asp Leu Ala Arg His Tyr Lys Ser Ala Ser Pro 
    930                 935                 940                 


Gln Pro Ala Phe Gln Ile Gln Pro Glu Thr Pro Leu Asn Ser Lys His 
945                 950                 955                 960 


His Ile Ile Gln Glu Leu Pro Leu Asp Asn Thr Phe Val Ala Cys Asp 
                965                 970                 975     


Ser Ile Ser Lys Cys Ser Ser Ser Ser Ser Asp Pro Tyr Ser Val Ser 
            980                 985                 990         


Asp Cys Gly Tyr Pro Val Thr Thr  Phe Glu Val Pro Val  Ser Val His 
        995                 1000                 1005             


Thr Arg  Pro Pro Met Lys Glu  Val Val Arg Ser Cys  Thr Pro Met 
    1010                 1015                 1020             


Lys Glu  Ser Thr Thr Met Glu  Ile Trp Ile His Pro  Gln Pro Gln 
    1025                 1030                 1035             


Arg Lys  Ser Glu Gly Lys Val  Ala Gly Lys Ser Gln  Arg Arg Val 
    1040                 1045                 1050             


Thr Phe  His Leu Pro Glu Gly  Ser Gln Glu Ser Ser  Ser Asp Gly 
    1055                 1060                 1065             


Gly Leu  Gly Asp His Asp Ala  Gly Ser Leu Thr Ser  Thr Ser His 
    1070                 1075                 1080             


Gly Leu  Pro Leu Gly Tyr Pro  Gln Glu Glu Tyr Phe  Asp Arg Ala 
    1085                 1090                 1095             


Thr Pro  Ser Asn Arg Thr Glu  Gly Asp Gly Asn Ser  Asp Pro Glu 
    1100                 1105                 1110             


Ser Thr  Ala Glu Ile Thr Val  Gln Pro Thr Val Glu  Glu Ala Ser 
    1115                 1120                 1125             


Asp Asn  Cys Thr Gln Glu Cys  Leu Ile Tyr Gly His  Ser Asp Ala 
    1130                 1135                 1140             


Cys Trp  Met Pro Ala Ser Leu  Asp His Ser Ser Ser  Ser Gln Ala 
    1145                 1150                 1155             


Gln Ala  Ser Ala Leu Cys His  Ser Pro Pro Leu Ser  Gln Ala Ser 
    1160                 1165                 1170             


Thr Gln  His His Ser Pro Arg  Val Thr Gln Thr Ile  Ala Leu Cys 
    1175                 1180                 1185             


His Ser  Pro Pro Val Thr Gln  Thr Ile Ala Leu Cys  His Ser Pro 
    1190                 1195                 1200             


Pro Pro  Ile Gln Val Ser Ala  Leu His His Ser Pro  Pro Leu Val 
    1205                 1210                 1215             


Gln Ala  Thr Ala Leu His His  Ser Pro Pro Ser Ala  Gln Ala Ser 
    1220                 1225                 1230             


Ala Leu  Cys Tyr Ser Pro Pro  Leu Ala Gln Ala Ala  Ala Ile Ser 
    1235                 1240                 1245             


His Ser  Ser Pro Leu Pro Gln  Val Ile Ala Leu His  Arg Ser Gln 
    1250                 1255                 1260             


Ala Gln  Ser Ser Val Ser Leu  Gln Gln Gly Trp Val  Gln Gly Ala 
    1265                 1270                 1275             


Asp Gly  Leu Cys Ser Val Asp  Gln Gly Val Gln Gly  Ser Ala Thr 
    1280                 1285                 1290             


Ser Gln  Phe Tyr Thr Met Ser  Glu Arg Leu His Pro  Ser Asp Asp 
    1295                 1300                 1305             


Ser Ile  Lys Val Ile Pro Leu  Thr Thr Phe Thr Pro  Arg Gln Gln 
    1310                 1315                 1320             


Ala Arg  Pro Ser Arg Gly Asp  Ser Pro Ile Met Glu  Glu His Pro 
    1325                 1330                 1335             


Leu 
    


<210>  3954
<211>  618
<212>  PRT
<213>  Homo sapiens

<400>  3954

Met Thr Gln Glu Tyr Asp Asn Lys Arg Pro Val Leu Val Leu Gln Asn 
1               5                   10                  15      


Glu Ala Leu Tyr Pro Gln Arg Arg Ser Tyr Thr Ser Glu Asp Glu Ala 
            20                  25                  30          


Trp Lys Ser Phe Leu Glu Asn Pro Leu Thr Ala Ala Thr Lys Ala Met 
        35                  40                  45              


Met Ser Ile Asn Gly Asp Glu Asp Ser Ala Ala Ala Leu Gly Leu Leu 
    50                  55                  60                  


Tyr Asp Tyr Tyr Lys Val Pro Arg Glu Arg Arg Ser Ser Thr Ala Lys 
65                  70                  75                  80  


Pro Glu Val Glu His Pro Glu Pro Asp His Ser Lys Arg Asn Ser Ile 
                85                  90                  95      


Pro Ile Val Thr Glu Gln Pro Leu Ile Ser Ala Gly Glu Asn Arg Val 
            100                 105                 110         


Gln Val Leu Lys Asn Val Pro Phe Asn Ile Val Leu Pro His Gly Asn 
        115                 120                 125             


Gln Leu Gly Ile Asp Lys Arg Gly His Leu Thr Ala Pro Asp Thr Thr 
    130                 135                 140                 


Val Thr Val Ser Ile Ala Thr Met Pro Thr His Ser Ile Lys Thr Glu 
145                 150                 155                 160 


Thr Gln Pro His Gly Phe Ala Val Gly Ile Pro Pro Ala Val Tyr His 
                165                 170                 175     


Pro Glu Pro Thr Glu Arg Val Val Val Phe Asp Arg Asn Leu Asn Thr 
            180                 185                 190         


Asp Gln Phe Ser Ser Gly Ala Gln Ala Pro Asn Ala Gln Arg Arg Thr 
        195                 200                 205             


Pro Asp Ser Thr Phe Ser Glu Thr Phe Lys Glu Gly Val Gln Glu Val 
    210                 215                 220                 


Phe Phe Pro Ser Asp Leu Ser Leu Arg Met Pro Gly Met Asn Ser Glu 
225                 230                 235                 240 


Asp Tyr Val Phe Asp Ser Val Ser Gly Asn Asn Phe Glu Tyr Thr Leu 
                245                 250                 255     


Glu Ala Ser Lys Ser Leu Arg Gln Lys Pro Gly Asp Ser Thr Met Thr 
            260                 265                 270         


Tyr Leu Asn Lys Gly Gln Phe Tyr Pro Ile Thr Leu Lys Glu Val Ser 
        275                 280                 285             


Ser Ser Glu Gly Ile His His Pro Ile Ser Lys Val Arg Ser Val Ile 
    290                 295                 300                 


Met Val Val Phe Ala Glu Asp Lys Ser Arg Glu Asp Gln Leu Arg His 
305                 310                 315                 320 


Trp Lys Tyr Trp His Ser Arg Gln His Thr Ala Lys Gln Arg Cys Ile 
                325                 330                 335     


Asp Ile Ala Asp Tyr Lys Glu Ser Phe Asn Thr Ile Ser Asn Ile Glu 
            340                 345                 350         


Glu Ile Ala Tyr Asn Ala Ile Ser Phe Thr Trp Asp Ile Asn Asp Glu 
        355                 360                 365             


Ala Lys Val Phe Ile Ser Val Asn Cys Leu Ser Thr Asp Phe Ser Ser 
    370                 375                 380                 


Gln Lys Gly Val Lys Gly Leu Pro Leu Asn Ile Gln Val Asp Thr Tyr 
385                 390                 395                 400 


Ser Tyr Asn Asn Arg Ser Asn Lys Pro Val His Arg Ala Tyr Cys Gln 
                405                 410                 415     


Ile Lys Val Phe Cys Asp Lys Gly Ala Glu Arg Lys Ile Arg Asp Glu 
            420                 425                 430         


Glu Arg Lys Gln Ser Lys Arg Lys Val Ser Asp Val Lys Val Pro Leu 
        435                 440                 445             


Leu Pro Ser His Lys Arg Met Asp Ile Thr Val Phe Lys Pro Phe Ile 
    450                 455                 460                 


Asp Leu Asp Thr Gln Pro Val Leu Phe Ile Pro Asp Val His Phe Ala 
465                 470                 475                 480 


Asn Leu Gln Arg Gly Thr His Val Leu Pro Ile Ala Ser Glu Glu Leu 
                485                 490                 495     


Glu Gly Glu Gly Ser Val Leu Lys Arg Gly Pro Tyr Gly Thr Glu Asp 
            500                 505                 510         


Asp Phe Ala Val Pro Pro Ser Thr Lys Leu Ala Arg Ile Glu Glu Pro 
        515                 520                 525             


Lys Arg Val Leu Leu Tyr Val Arg Lys Glu Ser Glu Glu Val Phe Asp 
    530                 535                 540                 


Ala Leu Met Leu Lys Thr Pro Ser Leu Lys Gly Leu Met Glu Ala Ile 
545                 550                 555                 560 


Ser Asp Lys Tyr Asp Val Pro His Asp Lys Ile Gly Lys Ile Phe Lys 
                565                 570                 575     


Lys Cys Lys Lys Gly Ile Leu Val Asn Met Asp Asp Asn Ile Val Lys 
            580                 585                 590         


His Tyr Ser Asn Glu Asp Thr Phe Gln Leu Gln Ile Glu Glu Ala Gly 
        595                 600                 605             


Gly Ser Tyr Lys Leu Thr Leu Thr Glu Ile 
    610                 615             


<210>  3955
<211>  1165
<212>  PRT
<213>  Homo sapiens

<400>  3955

Met Gln Asp Val Gln Gly Pro Arg Pro Gly Ser Pro Gly Asp Ala Glu 
1               5                   10                  15      


Asp Arg Arg Glu Leu Gly Leu His Arg Gly Glu Val Asn Phe Gly Gly 
            20                  25                  30          


Ser Gly Lys Lys Arg Gly Lys Phe Val Arg Val Pro Ser Gly Val Ala 
        35                  40                  45              


Pro Ser Val Leu Phe Asp Leu Leu Leu Ala Glu Trp His Leu Pro Ala 
    50                  55                  60                  


Pro Asn Leu Val Val Ser Leu Val Gly Glu Glu Gln Pro Phe Ala Met 
65                  70                  75                  80  


Lys Ser Trp Leu Arg Asp Val Leu Arg Lys Gly Leu Val Lys Ala Ala 
                85                  90                  95      


Gln Ser Thr Gly Ala Trp Ile Leu Thr Ser Ala Leu Arg Val Gly Leu 
            100                 105                 110         


Ala Arg His Val Gly Gln Ala Val Arg Asp His Ser Leu Ala Ser Thr 
        115                 120                 125             


Ser Thr Lys Val Arg Val Val Ala Val Gly Met Ala Ser Leu Gly Arg 
    130                 135                 140                 


Val Leu His Arg Arg Ile Leu Glu Glu Ala Gln Glu Asp Phe Pro Val 
145                 150                 155                 160 


His Tyr Pro Glu Asp Asp Gly Gly Ser Gln Gly Pro Leu Cys Ser Leu 
                165                 170                 175     


Asp Ser Asn Leu Ser His Phe Ile Leu Val Glu Pro Gly Pro Pro Gly 
            180                 185                 190         


Lys Gly Asp Gly Leu Thr Glu Leu Arg Leu Arg Leu Glu Lys His Ile 
        195                 200                 205             


Ser Glu Gln Arg Ala Gly Tyr Gly Gly Thr Gly Ser Ile Glu Ile Pro 
    210                 215                 220                 


Val Leu Cys Leu Leu Val Asn Gly Asp Pro Asn Thr Leu Glu Arg Ile 
225                 230                 235                 240 


Ser Arg Ala Val Glu Gln Ala Ala Pro Trp Leu Ile Leu Val Gly Ser 
                245                 250                 255     


Gly Gly Ile Ala Asp Val Leu Ala Ala Leu Val Asn Gln Pro His Leu 
            260                 265                 270         


Leu Val Pro Lys Val Ala Glu Lys Gln Phe Lys Glu Lys Phe Pro Ser 
        275                 280                 285             


Lys His Phe Ser Trp Glu Asp Ile Val Arg Trp Thr Lys Leu Leu Gln 
    290                 295                 300                 


Asn Ile Thr Ser His Gln His Leu Leu Thr Val Tyr Asp Phe Glu Gln 
305                 310                 315                 320 


Glu Gly Ser Glu Glu Leu Asp Thr Val Ile Leu Lys Ala Leu Val Lys 
                325                 330                 335     


Ala Cys Lys Ser His Ser Gln Glu Pro Gln Asp Tyr Leu Asp Glu Leu 
            340                 345                 350         


Lys Leu Ala Val Ala Trp Asp Arg Val Asp Ile Ala Lys Ser Glu Ile 
        355                 360                 365             


Phe Asn Gly Asp Val Glu Trp Lys Ser Cys Asp Leu Glu Glu Val Met 
    370                 375                 380                 


Val Asp Ala Leu Val Ser Asn Lys Pro Glu Phe Val Arg Leu Phe Val 
385                 390                 395                 400 


Asp Asn Gly Ala Asp Val Ala Asp Phe Leu Thr Tyr Gly Arg Leu Gln 
                405                 410                 415     


Glu Leu Tyr Arg Ser Val Ser Arg Lys Ser Leu Leu Phe Asp Leu Leu 
            420                 425                 430         


Gln Arg Lys Gln Glu Glu Ala Arg Leu Thr Leu Ala Gly Leu Gly Thr 
        435                 440                 445             


Gln Gln Ala Arg Glu Pro Pro Ala Gly Pro Pro Ala Phe Ser Leu His 
    450                 455                 460                 


Glu Val Ser Arg Val Leu Lys Asp Phe Leu Gln Asp Ala Cys Arg Gly 
465                 470                 475                 480 


Phe Tyr Gln Asp Gly Arg Pro Gly Asp Arg Arg Arg Ala Glu Lys Gly 
                485                 490                 495     


Pro Ala Lys Arg Pro Thr Gly Gln Lys Trp Leu Leu Asp Leu Asn Gln 
            500                 505                 510         


Lys Ser Glu Asn Pro Trp Arg Asp Leu Phe Leu Trp Ala Val Leu Gln 
        515                 520                 525             


Asn Arg His Glu Met Ala Thr Tyr Phe Trp Ala Met Gly Gln Glu Gly 
    530                 535                 540                 


Val Ala Ala Ala Leu Ala Ala Cys Lys Ile Leu Lys Glu Met Ser His 
545                 550                 555                 560 


Leu Glu Thr Glu Ala Glu Ala Ala Arg Ala Thr Arg Glu Ala Lys Tyr 
                565                 570                 575     


Glu Arg Leu Ala Leu Asp Leu Phe Ser Glu Cys Tyr Ser Asn Ser Glu 
            580                 585                 590         


Ala Arg Ala Phe Ala Leu Leu Val Arg Arg Asn Arg Cys Trp Ser Lys 
        595                 600                 605             


Thr Thr Cys Leu His Leu Ala Thr Glu Ala Asp Ala Lys Ala Phe Phe 
    610                 615                 620                 


Ala His Asp Gly Val Gln Ala Phe Leu Thr Arg Ile Trp Trp Gly Asp 
625                 630                 635                 640 


Met Ala Ala Gly Thr Pro Ile Leu Arg Leu Leu Gly Ala Phe Leu Cys 
                645                 650                 655     


Pro Ala Leu Val Tyr Thr Asn Leu Ile Thr Phe Ser Glu Glu Ala Pro 
            660                 665                 670         


Leu Arg Thr Gly Leu Glu Asp Leu Gln Asp Leu Asp Ser Leu Asp Thr 
        675                 680                 685             


Glu Lys Ser Pro Leu Tyr Gly Leu Gln Ser Arg Val Glu Glu Leu Val 
    690                 695                 700                 


Glu Ala Pro Arg Ala Gln Gly Asp Arg Gly Pro Arg Ala Val Phe Leu 
705                 710                 715                 720 


Leu Thr Arg Trp Arg Lys Phe Trp Gly Ala Pro Val Thr Val Phe Leu 
                725                 730                 735     


Gly Asn Val Val Met Tyr Phe Ala Phe Leu Phe Leu Phe Thr Tyr Val 
            740                 745                 750         


Leu Leu Val Asp Phe Arg Pro Pro Pro Gln Gly Pro Ser Gly Pro Glu 
        755                 760                 765             


Val Thr Leu Tyr Phe Trp Val Phe Thr Leu Val Leu Glu Glu Ile Arg 
    770                 775                 780                 


Gln Gly Phe Phe Thr Asp Glu Asp Thr His Leu Val Lys Lys Phe Thr 
785                 790                 795                 800 


Leu Tyr Val Gly Asp Asn Trp Asn Lys Cys Asp Met Val Ala Ile Phe 
                805                 810                 815     


Leu Phe Ile Val Gly Val Thr Cys Arg Met Leu Pro Ser Ala Phe Glu 
            820                 825                 830         


Ala Gly Arg Thr Val Leu Ala Met Asp Phe Met Val Phe Thr Leu Arg 
        835                 840                 845             


Leu Ile His Ile Phe Ala Ile His Lys Gln Leu Gly Pro Lys Ile Ile 
    850                 855                 860                 


Val Val Glu Arg Met Met Lys Asp Val Phe Phe Phe Leu Phe Phe Leu 
865                 870                 875                 880 


Ser Val Trp Leu Val Ala Tyr Gly Val Thr Thr Gln Ala Leu Leu His 
                885                 890                 895     


Pro His Asp Gly Arg Leu Glu Trp Ile Phe Arg Arg Val Leu Tyr Arg 
            900                 905                 910         


Pro Tyr Leu Gln Ile Phe Gly Gln Ile Pro Leu Asp Glu Ile Asp Glu 
        915                 920                 925             


Ala Arg Val Asn Cys Ser Thr His Pro Leu Leu Leu Glu Asp Ser Pro 
    930                 935                 940                 


Ser Cys Pro Ser Leu Tyr Ala Asn Trp Leu Val Ile Leu Leu Leu Val 
945                 950                 955                 960 


Thr Phe Leu Leu Val Thr Asn Val Leu Leu Met Asn Leu Leu Ile Ala 
                965                 970                 975     


Met Phe Ser Tyr Thr Phe Gln Val Val Gln Gly Asn Ala Asp Met Phe 
            980                 985                 990         


Trp Lys Phe Gln Arg Tyr Asn Leu  Ile Val Glu Tyr His  Glu Arg Pro 
        995                 1000                 1005             


Ala Leu  Ala Pro Pro Phe Ile  Leu Leu Ser His Leu  Ser Leu Thr 
    1010                 1015                 1020             


Leu Arg  Arg Val Phe Lys Lys  Glu Ala Glu His Lys  Arg Glu His 
    1025                 1030                 1035             


Leu Glu  Arg Asp Leu Pro Asp  Pro Leu Asp Gln Lys  Val Val Thr 
    1040                 1045                 1050             


Trp Glu  Thr Val Gln Lys Glu  Asn Phe Leu Ser Lys  Met Glu Lys 
    1055                 1060                 1065             


Arg Arg  Arg Asp Ser Glu Gly  Glu Val Leu Arg Lys  Thr Ala His 
    1070                 1075                 1080             


Arg Val  Asp Phe Ile Ala Lys  Tyr Leu Gly Gly Leu  Arg Glu Gln 
    1085                 1090                 1095             


Glu Lys  Arg Ile Lys Cys Leu  Glu Ser Gln Ile Asn  Tyr Cys Ser 
    1100                 1105                 1110             


Val Leu  Val Ser Ser Val Ala  Asp Val Leu Ala Gln  Gly Gly Gly 
    1115                 1120                 1125             


Pro Arg  Ser Ser Gln His Cys  Gly Glu Gly Ser Gln  Leu Val Ala 
    1130                 1135                 1140             


Ala Asp  His Arg Gly Gly Leu  Asp Gly Trp Glu Gln  Pro Gly Ala 
    1145                 1150                 1155             


Gly Gln  Pro Pro Ser Asp Thr  
    1160                 1165 


<210>  3956
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  3956

Met Arg Glu Asn Asn Gln Ser Ser Thr Leu Glu Phe Ile Leu Leu Gly 
1               5                   10                  15      


Val Thr Gly Gln Gln Glu Gln Glu Asp Phe Phe Tyr Ile Leu Phe Leu 
            20                  25                  30          


Phe Ile Tyr Pro Ile Thr Leu Ile Gly Asn Leu Leu Ile Val Leu Ala 
        35                  40                  45              


Ile Cys Ser Asp Val Arg Leu His Asn Pro Met Tyr Phe Leu Leu Ala 
    50                  55                  60                  


Asn Leu Ser Leu Val Asp Ile Phe Phe Ser Ser Val Thr Ile Pro Lys 
65                  70                  75                  80  


Met Leu Ala Asn His Leu Leu Gly Ser Lys Ser Ile Ser Phe Gly Gly 
                85                  90                  95      


Cys Leu Thr Gln Met Tyr Phe Met Ile Ala Leu Gly Asn Thr Asp Ser 
            100                 105                 110         


Tyr Ile Leu Ala Ala Met Ala Tyr Asp Arg Ala Val Ala Ile Ser Arg 
        115                 120                 125             


Pro Leu His Tyr Thr Thr Ile Met Ser Pro Arg Ser Cys Ile Trp Leu 
    130                 135                 140                 


Ile Ala Gly Ser Trp Val Ile Gly Asn Ala Asn Ala Leu Pro His Thr 
145                 150                 155                 160 


Leu Leu Thr Ala Ser Leu Ser Phe Cys Gly Asn Gln Glu Val Ala Asn 
                165                 170                 175     


Phe Tyr Cys Asp Ile Thr Pro Leu Leu Lys Leu Ser Cys Ser Asp Ile 
            180                 185                 190         


His Phe His Val Lys Met Met Tyr Leu Gly Val Gly Ile Phe Ser Val 
        195                 200                 205             


Pro Leu Leu Cys Ile Ile Val Ser Tyr Ile Arg Val Phe Ser Thr Val 
    210                 215                 220                 


Phe Gln Val Pro Ser Thr Lys Gly Val Leu Lys Ala Phe Ser Thr Cys 
225                 230                 235                 240 


Gly Ser His Leu Thr Val Val Ser Leu Tyr Tyr Gly Thr Val Met Gly 
                245                 250                 255     


Thr Tyr Phe Arg Pro Leu Thr Asn Tyr Ser Leu Lys Asp Ala Val Ile 
            260                 265                 270         


Thr Val Met Tyr Thr Ala Val Thr Pro Met Leu Asn Pro Phe Ile Tyr 
        275                 280                 285             


Ser Leu Arg Asn Arg Asp Met Lys Ala Ala Leu Arg Lys Leu Phe Asn 
    290                 295                 300                 


Lys Arg Ile Ser Ser 
305                 


<210>  3957
<211>  940
<212>  PRT
<213>  Homo sapiens

<400>  3957

Met Asn Arg Ile Arg Lys Phe Phe Arg Gly Ser Gly Arg Val Leu Ala 
1               5                   10                  15      


Phe Ile Phe Val Ala Ser Val Ile Trp Leu Leu Phe Asp Met Ala Ala 
            20                  25                  30          


Leu Arg Leu Ser Phe Ser Glu Ile Asn Thr Arg Val Ile Lys Glu Asp 
        35                  40                  45              


Ile Val Arg Arg Glu Arg Ile Gly Phe Arg Val Gln Pro Asp Gln Gly 
    50                  55                  60                  


Lys Ile Phe Tyr Ser Ser Ile Lys Glu Met Lys Pro Pro Leu Arg Gly 
65                  70                  75                  80  


His Gly Lys Gly Ala Trp Gly Lys Glu Asn Val Arg Lys Thr Glu Glu 
                85                  90                  95      


Ser Val Leu Lys Val Glu Val Asp Leu Asp Gln Thr Gln Arg Glu Arg 
            100                 105                 110         


Lys Met Gln Asn Ala Leu Gly Arg Gly Lys Val Val Pro Leu Trp His 
        115                 120                 125             


Pro Ala His Leu Gln Thr Leu Pro Val Thr Pro Asn Lys Gln Lys Thr 
    130                 135                 140                 


Asp Gly Arg Gly Thr Lys Pro Glu Ala Ser Ser His Gln Gly Thr Pro 
145                 150                 155                 160 


Lys Gln Thr Thr Ala Gln Gly Ala Pro Lys Thr Ser Phe Ile Ala Ala 
                165                 170                 175     


Lys Gly Thr Gln Val Val Lys Ile Ser Val His Met Gly Arg Val Ser 
            180                 185                 190         


Leu Lys Gln Glu Pro Arg Lys Ser His Ser Pro Ser Ser Asp Thr Ser 
        195                 200                 205             


Lys Leu Ala Ala Glu Arg Asp Leu Asn Val Thr Ile Ser Leu Ser Thr 
    210                 215                 220                 


Asp Arg Pro Lys Gln Arg Ser Gln Ala Val Ala Asn Glu Arg Ala His 
225                 230                 235                 240 


Pro Ala Ser Thr Ala Val Pro Lys Ser Gly Glu Ala Met Ala Leu Asn 
                245                 250                 255     


Lys Thr Lys Thr Gln Ser Lys Glu Val Asn Ala Asn Lys His Lys Ala 
            260                 265                 270         


Asn Thr Ser Leu Pro Phe Pro Lys Phe Thr Val Asn Ser Asn Arg Leu 
        275                 280                 285             


Arg Lys Gln Ser Ile Asn Glu Thr Pro Leu Gly Ser Leu Ser Lys Asp 
    290                 295                 300                 


Asp Gly Ala Arg Gly Ala His Gly Lys Lys Leu Asn Phe Ser Glu Ser 
305                 310                 315                 320 


His Leu Val Ile Ile Thr Lys Glu Glu Glu Gln Lys Ala Asp Pro Lys 
                325                 330                 335     


Glu Val Ser Asn Ser Lys Thr Lys Thr Ile Phe Pro Lys Val Leu Gly 
            340                 345                 350         


Lys Ser Gln Ser Lys His Ile Ser Arg Asn Arg Ser Glu Met Ser Ser 
        355                 360                 365             


Ser Ser Leu Ala Pro His Arg Val Pro Leu Ser Gln Thr Asn His Ala 
    370                 375                 380                 


Leu Thr Gly Gly Leu Glu Pro Ala Lys Ile Asn Ile Thr Ala Lys Ala 
385                 390                 395                 400 


Pro Ser Thr Glu Tyr Asn Gln Ser His Ile Lys Ala Leu Leu Pro Glu 
                405                 410                 415     


Asp Ser Gly Thr His Gln Val Leu Arg Ile Asp Val Thr Leu Ser Pro 
            420                 425                 430         


Arg Asp Pro Lys Ala Pro Gly Gln Phe Gly Arg Pro Val Val Val Pro 
        435                 440                 445             


His Gly Lys Glu Lys Glu Ala Glu Arg Arg Trp Lys Glu Gly Asn Phe 
    450                 455                 460                 


Asn Val Tyr Leu Ser Asp Leu Ile Pro Val Asp Arg Ala Ile Glu Asp 
465                 470                 475                 480 


Thr Arg Pro Ala Gly Cys Ala Glu Gln Leu Val His Asn Asn Leu Pro 
                485                 490                 495     


Thr Thr Ser Val Ile Met Cys Phe Val Asp Glu Val Trp Ser Thr Leu 
            500                 505                 510         


Leu Arg Ser Val His Ser Val Ile Asn Arg Ser Pro Pro His Leu Ile 
        515                 520                 525             


Lys Glu Ile Leu Leu Val Asp Asp Phe Ser Thr Lys Asp Tyr Leu Lys 
    530                 535                 540                 


Asp Asn Leu Asp Lys Tyr Met Ser Gln Phe Pro Lys Val Arg Ile Leu 
545                 550                 555                 560 


Arg Leu Lys Glu Arg His Gly Leu Ile Arg Ala Arg Leu Ala Gly Ala 
                565                 570                 575     


Gln Asn Ala Thr Gly Asp Val Leu Thr Phe Leu Asp Ser His Val Glu 
            580                 585                 590         


Cys Asn Val Gly Trp Leu Glu Pro Leu Leu Glu Arg Val Tyr Leu Ser 
        595                 600                 605             


Arg Lys Lys Val Ala Cys Pro Val Ile Glu Val Ile Asn Asp Lys Asp 
    610                 615                 620                 


Met Ser Tyr Met Thr Val Asp Asn Phe Gln Arg Gly Ile Phe Val Trp 
625                 630                 635                 640 


Pro Met Asn Phe Gly Trp Arg Thr Ile Pro Pro Asp Val Ile Ala Lys 
                645                 650                 655     


Asn Arg Ile Lys Glu Thr Asp Thr Ile Arg Cys Pro Val Met Ala Gly 
            660                 665                 670         


Gly Leu Phe Ser Ile Asp Lys Ser Tyr Phe Phe Glu Leu Gly Thr Tyr 
        675                 680                 685             


Asp Pro Gly Leu Asp Val Trp Gly Gly Glu Asn Met Glu Leu Ser Phe 
    690                 695                 700                 


Lys Val Trp Met Cys Gly Gly Glu Ile Glu Ile Ile Pro Cys Ser Arg 
705                 710                 715                 720 


Val Gly His Ile Phe Arg Asn Asp Asn Pro Tyr Ser Phe Pro Lys Asp 
                725                 730                 735     


Arg Met Lys Thr Val Glu Arg Asn Leu Val Arg Val Ala Glu Val Trp 
            740                 745                 750         


Leu Asp Glu Tyr Lys Glu Leu Phe Tyr Gly His Gly Asp His Leu Ile 
        755                 760                 765             


Asp Gln Gly Leu Asp Val Gly Asn Leu Thr Gln Gln Arg Glu Leu Arg 
    770                 775                 780                 


Lys Lys Leu Lys Cys Lys Ser Phe Lys Trp Tyr Leu Glu Asn Val Phe 
785                 790                 795                 800 


Pro Asp Leu Arg Ala Pro Ile Val Arg Ala Ser Gly Val Leu Ile Asn 
                805                 810                 815     


Val Ala Leu Gly Lys Cys Ile Ser Ile Glu Asn Thr Thr Val Ile Leu 
            820                 825                 830         


Glu Asp Cys Asp Gly Ser Lys Glu Leu Gln Gln Phe Asn Tyr Thr Trp 
        835                 840                 845             


Leu Arg Leu Ile Lys Cys Gly Glu Trp Cys Ile Ala Pro Ile Pro Asp 
    850                 855                 860                 


Lys Gly Ala Val Arg Leu His Pro Cys Asp Asn Arg Asn Lys Gly Leu 
865                 870                 875                 880 


Lys Trp Leu His Lys Ser Thr Ser Val Phe His Pro Glu Leu Val Asn 
                885                 890                 895     


His Ile Val Phe Glu Asn Asn Gln Gln Leu Leu Cys Leu Glu Gly Asn 
            900                 905                 910         


Phe Ser Gln Lys Ile Leu Lys Val Ala Ala Cys Asp Pro Val Lys Pro 
        915                 920                 925             


Tyr Gln Lys Trp Lys Phe Glu Lys Tyr Tyr Glu Ala 
    930                 935                 940 


<210>  3958
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  3958

Met Gly Ala Pro Ala Thr Arg Arg Cys Val Glu Trp Leu Leu Gly Leu 
1               5                   10                  15      


Tyr Phe Leu Ser His Ile Pro Ile Thr Leu Phe Met Asp Leu Gln Ala 
            20                  25                  30          


Val Leu Pro Arg Glu Leu Tyr Pro Val Glu Phe Arg Asn Leu Leu Lys 
        35                  40                  45              


Trp Tyr Ala Lys Glu Phe Lys Asp Pro Leu Leu Gln Glu Pro Pro Ala 
    50                  55                  60                  


Trp Phe Lys Ser Phe Leu Phe Cys Glu Leu Val Phe Gln Leu Pro Phe 
65                  70                  75                  80  


Phe Pro Ile Ala Thr Tyr Ala Phe Leu Lys Gly Ser Cys Lys Trp Ile 
                85                  90                  95      


Arg Thr Pro Ala Ile Ile Tyr Ser Val His Thr Met Thr Thr Leu Ile 
            100                 105                 110         


Pro Ile Leu Ser Thr Phe Leu Phe Glu Asp Phe Ser Lys Ala Ser Gly 
        115                 120                 125             


Phe Lys Gly Gln Arg Pro Glu Thr Leu His Glu Arg Leu Thr Leu Val 
    130                 135                 140                 


Ser Val Tyr Ala Pro Tyr Leu Leu Ile Pro Phe Ile Leu Leu Ile Phe 
145                 150                 155                 160 


Met Leu Arg Ser Pro Tyr Tyr Lys Tyr Glu Glu Lys Arg Lys Lys Lys 
                165                 170                 175     


<210>  3959
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  3959

Met Glu Gln Leu Leu Gly Ile Lys Leu Gly Cys Leu Phe Ala Leu Leu 
1               5                   10                  15      


Ala Leu Thr Leu Gly Cys Gly Leu Thr Pro Ile Cys Phe Lys Trp Phe 
            20                  25                  30          


Gln Ile Asp Ala Ala Arg Gly His His Arg Leu Val Leu Arg Leu Leu 
        35                  40                  45              


Gly Cys Ile Ser Ala Gly Val Phe Leu Gly Ala Gly Phe Met His Met 
    50                  55                  60                  


Thr Ala Glu Ala Leu Glu Glu Ile Glu Ser Gln Ile Gln Lys Phe Met 
65                  70                  75                  80  


Val Gln Asn Arg Ser Ala Ser Glu Arg Asn Ser Ser Gly Asp Ala Asp 
                85                  90                  95      


Ser Ala His Met Glu Tyr Pro Tyr Gly Glu Leu Ile Ile Ser Leu Gly 
            100                 105                 110         


Phe Phe Phe Val Phe Phe Leu Glu Ser Leu Ala Leu Gln Cys Cys Pro 
        115                 120                 125             


Gly Ala Ala Gly Gly Ser Thr Val Gln Asp Glu Glu Trp Gly Gly Ala 
    130                 135                 140                 


His Ile Phe Glu Leu His Ser His Gly His Leu Pro Ser Pro Ser Lys 
145                 150                 155                 160 


Gly Pro Leu Arg Ala Leu Val Leu Leu Leu Ser Leu Ser Phe His Ser 
                165                 170                 175     


Val Phe Glu Gly Leu Ala Val Gly Leu Gln Pro Thr Val Ala Ala Thr 
            180                 185                 190         


Val Gln Leu Cys Leu Ala Val Leu Ala His Lys Gly Leu Val Val Phe 
        195                 200                 205             


Gly Val Gly Met Arg Leu Val His Leu Gly Thr Ser Ser Arg Trp Ala 
    210                 215                 220                 


Val Phe Ser Ile Leu Leu Leu Ala Leu Met Ser Pro Leu Gly Leu Ala 
225                 230                 235                 240 


Val Gly Leu Ala Val Thr Gly Gly Asp Ser Glu Gly Gly Arg Gly Leu 
                245                 250                 255     


Ala Gln Ala Val Leu Glu Gly Val Ala Ala Gly Thr Phe Leu Tyr Val 
            260                 265                 270         


Thr Phe Leu Glu Ile Leu Pro Arg Glu Leu Ala Ser Pro Glu Ala Pro 
        275                 280                 285             


Leu Ala Lys Trp Ser Cys Val Ala Ala Gly Phe Ala Phe Met Ala Phe 
    290                 295                 300                 


Ile Ala Leu Trp Ala 
305                 


<210>  3960
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  3960

Met Thr Pro Glu Asp Pro Glu Glu Thr Gln Pro Leu Leu Gly Pro Pro 
1               5                   10                  15      


Gly Gly Ser Ala Pro Arg Gly Arg Arg Val Phe Leu Ala Ala Phe Ala 
            20                  25                  30          


Ala Ala Leu Gly Pro Leu Ser Phe Gly Phe Ala Leu Gly Tyr Ser Ser 
        35                  40                  45              


Pro Ala Ile Pro Ser Leu Gln Arg Ala Ala Pro Pro Ala Pro Arg Leu 
    50                  55                  60                  


Asp Asp Ala Ala Ala Ser Trp Phe Gly Ala Val Val Thr Leu Gly Ala 
65                  70                  75                  80  


Ala Ala Gly Gly Val Leu Gly Gly Trp Leu Val Asp Arg Ala Gly Arg 
                85                  90                  95      


Lys Leu Ser Leu Leu Leu Cys Ser Val Pro Phe Val Ala Gly Phe Ala 
            100                 105                 110         


Val Ile Thr Ala Ala Gln Asp Val Trp Met Leu Leu Gly Gly Arg Leu 
        115                 120                 125             


Leu Thr Gly Leu Ala Cys Gly Val Ala Ser Leu Val Ala Pro Val Tyr 
    130                 135                 140                 


Ile Ser Glu Ile Ala Tyr Pro Ala Val Arg Gly Leu Leu Gly Ser Cys 
145                 150                 155                 160 


Val Gln Leu Met Val Val Val Gly Ile Leu Leu Ala Tyr Leu Ala Gly 
                165                 170                 175     


Trp Val Leu Glu Trp Arg Trp Leu Ala Val Leu Gly Cys Val Pro Pro 
            180                 185                 190         


Ser Leu Met Leu Leu Leu Met Cys Phe Met Pro Glu Thr Pro Arg Phe 
        195                 200                 205             


Leu Leu Thr Gln His Arg Arg Gln Glu Ala Met Ala Ala Leu Arg Phe 
    210                 215                 220                 


Leu Trp Gly Ser Glu Gln Gly Trp Glu Asp Pro Pro Ile Gly Ala Glu 
225                 230                 235                 240 


Gln Ser Phe His Leu Ala Leu Leu Arg Gln Pro Gly Ile Tyr Lys Pro 
                245                 250                 255     


Phe Ile Ile Gly Val Ser Leu Met Ala Phe Gln Gln Leu Ser Gly Val 
            260                 265                 270         


Asn Ala Val Met Phe Tyr Ala Glu Thr Ile Phe Glu Glu Ala Lys Phe 
        275                 280                 285             


Lys Asp Ser Ser Leu Ala Ser Val Val Val Gly Val Ile Gln Val Leu 
    290                 295                 300                 


Phe Thr Ala Val Ala Ala Leu Ile Met Asp Arg Ala Gly Arg Arg Leu 
305                 310                 315                 320 


Leu Leu Val Leu Ser Gly Val Val Met Val Phe Ser Thr Ser Ala Phe 
                325                 330                 335     


Gly Ala Tyr Phe Lys Leu Thr Gln Gly Gly Pro Gly Asn Ser Ser His 
            340                 345                 350         


Val Ala Ile Ser Ala Pro Val Ser Ala Gln Pro Val Asp Ala Ser Val 
        355                 360                 365             


Gly Leu Ala Trp Leu Ala Val Gly Ser Met Cys Leu Phe Ile Ala Gly 
    370                 375                 380                 


Phe Ala Val Gly Trp Gly Pro Ile Pro Trp Leu Leu Met Ser Glu Ile 
385                 390                 395                 400 


Phe Pro Leu His Val Lys Gly Val Ala Thr Gly Ile Cys Val Leu Thr 
                405                 410                 415     


Asn Trp Leu Met Ala Phe Leu Val Thr Lys Glu Phe Ser Ser Leu Met 
            420                 425                 430         


Glu Val Leu Arg Pro Tyr Gly Ala Phe Trp Leu Ala Ser Ala Phe Cys 
        435                 440                 445             


Ile Phe Ser Val Leu Phe Thr Leu Phe Cys Val Pro Glu Thr Lys Gly 
    450                 455                 460                 


Lys Thr Leu Glu Gln Ile Thr Ala His Phe Glu Gly Arg 
465                 470                 475         


<210>  3961
<211>  571
<212>  PRT
<213>  Homo sapiens

<400>  3961

Met Thr Arg Ala Gly Asp His Asn Arg Gln Arg Gly Cys Cys Gly Ser 
1               5                   10                  15      


Leu Ala Asp Tyr Leu Thr Ser Ala Lys Phe Leu Leu Tyr Leu Gly His 
            20                  25                  30          


Ser Leu Ser Thr Trp Gly Asp Arg Met Trp His Phe Ala Val Ser Val 
        35                  40                  45              


Phe Leu Val Glu Leu Tyr Gly Asn Ser Leu Leu Leu Thr Ala Val Tyr 
    50                  55                  60                  


Gly Leu Val Val Ala Gly Ser Val Leu Val Leu Gly Ala Ile Ile Gly 
65                  70                  75                  80  


Asp Trp Val Asp Lys Asn Ala Arg Leu Lys Val Ala Gln Thr Ser Leu 
                85                  90                  95      


Val Val Gln Asn Val Ser Val Ile Leu Cys Gly Ile Ile Leu Met Met 
            100                 105                 110         


Val Phe Leu His Lys His Glu Leu Leu Thr Met Tyr His Gly Trp Val 
        115                 120                 125             


Leu Thr Ser Cys Tyr Ile Leu Ile Ile Thr Ile Ala Asn Ile Ala Asn 
    130                 135                 140                 


Leu Ala Ser Thr Ala Thr Ala Ile Thr Ile Gln Arg Asp Trp Ile Val 
145                 150                 155                 160 


Val Val Ala Gly Glu Asp Arg Ser Lys Leu Ala Asn Met Asn Ala Thr 
                165                 170                 175     


Ile Arg Arg Ile Asp Gln Leu Thr Asn Ile Leu Ala Pro Met Ala Val 
            180                 185                 190         


Gly Gln Ile Met Thr Phe Gly Ser Pro Val Ile Gly Cys Gly Phe Ile 
        195                 200                 205             


Ser Gly Trp Asn Leu Val Ser Met Cys Val Glu Tyr Val Leu Leu Trp 
    210                 215                 220                 


Lys Val Tyr Gln Lys Thr Pro Ala Leu Ala Val Lys Ala Gly Leu Lys 
225                 230                 235                 240 


Glu Glu Glu Thr Glu Leu Lys Gln Leu Asn Leu His Lys Asp Thr Glu 
                245                 250                 255     


Pro Lys Pro Leu Glu Gly Thr His Leu Met Gly Val Lys Asp Ser Asn 
            260                 265                 270         


Ile His Glu Leu Glu His Glu Gln Glu Pro Thr Cys Ala Ser Gln Met 
        275                 280                 285             


Ala Glu Pro Phe Arg Thr Phe Arg Asp Gly Trp Val Ser Tyr Tyr Asn 
    290                 295                 300                 


Gln Pro Val Phe Leu Ala Gly Met Gly Leu Ala Phe Leu Tyr Met Thr 
305                 310                 315                 320 


Val Leu Gly Phe Asp Cys Ile Thr Thr Gly Tyr Ala Tyr Thr Gln Gly 
                325                 330                 335     


Leu Ser Gly Ser Ile Leu Ser Ile Leu Met Gly Ala Ser Ala Ile Thr 
            340                 345                 350         


Gly Ile Met Gly Thr Val Ala Phe Thr Trp Leu Arg Arg Lys Cys Gly 
        355                 360                 365             


Leu Val Arg Thr Gly Leu Ile Ser Gly Leu Ala Gln Leu Ser Cys Leu 
    370                 375                 380                 


Ile Leu Cys Val Ile Ser Val Phe Met Pro Gly Ser Pro Leu Asp Leu 
385                 390                 395                 400 


Ser Val Ser Pro Phe Glu Asp Ile Arg Ser Arg Phe Ile Gln Gly Glu 
                405                 410                 415     


Ser Ile Thr Pro Thr Lys Ile Pro Glu Ile Thr Thr Glu Ile Tyr Met 
            420                 425                 430         


Ser Asn Gly Ser Asn Ser Ala Asn Ile Val Pro Glu Thr Ser Pro Glu 
        435                 440                 445             


Ser Val Pro Ile Ile Ser Val Ser Leu Leu Phe Ala Gly Val Ile Ala 
    450                 455                 460                 


Ala Arg Ile Gly Leu Trp Ser Phe Asp Leu Thr Val Thr Gln Leu Leu 
465                 470                 475                 480 


Gln Glu Asn Val Ile Glu Ser Glu Arg Gly Ile Ile Asn Gly Val Gln 
                485                 490                 495     


Asn Ser Met Asn Tyr Leu Leu Asp Leu Leu His Phe Ile Met Val Ile 
            500                 505                 510         


Leu Ala Pro Asn Pro Glu Ala Phe Gly Leu Leu Val Leu Ile Ser Val 
        515                 520                 525             


Ser Phe Val Ala Met Gly His Ile Met Tyr Phe Arg Phe Ala Gln Asn 
    530                 535                 540                 


Thr Leu Gly Asn Lys Leu Phe Ala Cys Gly Pro Asp Ala Lys Glu Val 
545                 550                 555                 560 


Arg Lys Glu Asn Gln Ala Asn Thr Ser Val Val 
                565                 570     


<210>  3962
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  3962

Met Lys Ser Pro His Val Leu Val Phe Leu Cys Leu Leu Val Ala Leu 
1               5                   10                  15      


Val Thr Gly Asn Leu Val Gln Phe Gly Val Met Ile Glu Lys Met Thr 
            20                  25                  30          


Gly Lys Ser Ala Leu Gln Tyr Asn Asp Tyr Gly Cys Tyr Cys Gly Ile 
        35                  40                  45              


Gly Gly Ser His Trp Pro Val Asp Gln Thr Asp Trp Cys Cys His Ala 
    50                  55                  60                  


His Asp Cys Cys Tyr Gly Arg Leu Glu Lys Leu Gly Cys Glu Pro Lys 
65                  70                  75                  80  


Leu Glu Lys Tyr Leu Phe Ser Val Ser Glu Arg Gly Ile Phe Cys Ala 
                85                  90                  95      


Gly Arg Thr Thr Cys Gln Arg Leu Thr Cys Glu Cys Asp Lys Arg Ala 
            100                 105                 110         


Ala Leu Cys Phe Arg Arg Asn Leu Gly Thr Tyr Asn Arg Lys Tyr Ala 
        115                 120                 125             


His Tyr Pro Asn Lys Leu Cys Thr Gly Pro Thr Pro Pro Cys 
    130                 135                 140         


<210>  3963
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  3963

Met Ala Leu Pro Tyr His Ile Phe Leu Phe Thr Val Leu Leu Pro Ser 
1               5                   10                  15      


Phe Thr Leu Thr Ala Pro Pro Pro Cys Arg Cys Met Thr Ser Ser Ser 
            20                  25                  30          


Pro Tyr Gln Glu Phe Leu Trp Arg Met Gln Arg Pro Gly Asn Ile Asp 
        35                  40                  45              


Ala Pro Ser Tyr Arg Ser Leu Ser Lys Gly Thr Pro Thr Phe Thr Ala 
    50                  55                  60                  


His Thr His Met Pro Arg Asn Cys Tyr His Ser Ala Thr Leu Cys Met 
65                  70                  75                  80  


His Ala Asn Thr His Tyr Trp Thr Gly Lys Met Ile Asn Pro Ser Cys 
                85                  90                  95      


Pro Gly Gly Leu Gly Val Thr Val Cys Trp Thr Tyr Phe Thr Gln Thr 
            100                 105                 110         


Gly Met Ser Asp Gly Gly Gly Val Gln Asp Gln Ala Arg Glu Lys His 
        115                 120                 125             


Val Lys Glu Val Ile Ser Gln Leu Thr Arg Val His Gly Thr Ser Ser 
    130                 135                 140                 


Pro Tyr Lys Gly Leu Asp Leu Ser Lys Leu His Glu Thr Leu Arg Thr 
145                 150                 155                 160 


His Thr Arg Leu Val Ser Leu Phe Asn Thr Thr Leu Thr Gly Leu His 
                165                 170                 175     


Glu Val Ser Ala Gln Asn Pro Thr Asn Cys Trp Ile Cys Leu Pro Leu 
            180                 185                 190         


Asn Phe Arg Pro Tyr Val Ser Ile Pro Val Pro Glu Gln Trp Asn Asn 
        195                 200                 205             


Phe Ser Thr Glu Ile Asn Thr Thr Ser Val Leu Val Gly Pro Leu Val 
    210                 215                 220                 


Ser Asn Leu Glu Ile Thr His Thr Ser Asn Leu Thr Cys Val Lys Phe 
225                 230                 235                 240 


Ser Asn Thr Thr Tyr Thr Thr Asn Ser Gln Cys Ile Arg Trp Val Thr 
                245                 250                 255     


Pro Pro Thr Gln Ile Val Cys Leu Pro Ser Gly Ile Phe Phe Val Cys 
            260                 265                 270         


Gly Thr Ser Ala Tyr Arg Cys Leu Asn Gly Ser Ser Glu Ser Met Cys 
        275                 280                 285             


Phe Leu Ser Phe Leu Val Pro Pro Met Thr Ile Tyr Thr Glu Gln Asp 
    290                 295                 300                 


Leu Tyr Ser Tyr Val Ile Ser Lys Pro Arg Asn Lys Arg Val Pro Ile 
305                 310                 315                 320 


Leu Pro Phe Val Ile Gly Ala Gly Val Leu Gly Ala Leu Gly Thr Gly 
                325                 330                 335     


Ile Gly Gly Ile Thr Thr Ser Thr Gln Phe Tyr Tyr Lys Leu Ser Gln 
            340                 345                 350         


Glu Leu Asn Gly Asp Met Glu Arg Val Ala Asp Ser Leu Val Thr Leu 
        355                 360                 365             


Gln Asp Gln Leu Asn Ser Leu Ala Ala Val Val Leu Gln Asn Arg Arg 
    370                 375                 380                 


Ala Leu Asp Leu Leu Thr Ala Glu Arg Gly Gly Thr Cys Leu Phe Leu 
385                 390                 395                 400 


Gly Glu Glu Cys Cys Tyr Tyr Val Asn Gln Ser Gly Ile Val Thr Glu 
                405                 410                 415     


Lys Val Lys Glu Ile Arg Asp Arg Ile Gln Arg Arg Ala Glu Glu Leu 
            420                 425                 430         


Arg Asn Thr Gly Pro Trp Gly Leu Leu Ser Gln Trp Met Pro Trp Ile 
        435                 440                 445             


Leu Pro Phe Leu Gly Pro Leu Ala Ala Ile Ile Leu Leu Leu Leu Phe 
    450                 455                 460                 


Gly Pro Cys Ile Phe Asn Leu Leu Val Asn Phe Val Ser Ser Arg Ile 
465                 470                 475                 480 


Glu Ala Val Lys Leu Gln Met Glu Pro Lys Met Gln Ser Lys Thr Lys 
                485                 490                 495     


Ile Tyr Arg Arg Pro Leu Asp Arg Pro Ala Ser Pro Arg Ser Asp Val 
            500                 505                 510         


Asn Asp Ile Lys Gly Thr Pro Pro Glu Glu Ile Ser Ala Ala Gln Pro 
        515                 520                 525             


Leu Leu Arg Pro Asn Ser Ala Gly Ser Ser 
    530                 535             


<210>  3964
<211>  1177
<212>  PRT
<213>  Homo sapiens

<400>  3964

Met Trp Arg Trp Ile Arg Gln Gln Leu Gly Phe Asp Pro Pro His Gln 
1               5                   10                  15      


Ser Asp Thr Arg Thr Ile Tyr Val Ala Asn Arg Phe Pro Gln Asn Gly 
            20                  25                  30          


Leu Tyr Thr Pro Gln Lys Phe Ile Asp Asn Arg Ile Ile Ser Ser Lys 
        35                  40                  45              


Tyr Thr Val Trp Asn Phe Val Pro Lys Asn Leu Phe Glu Gln Phe Arg 
    50                  55                  60                  


Arg Val Ala Asn Phe Tyr Phe Leu Ile Ile Phe Leu Val Gln Leu Met 
65                  70                  75                  80  


Ile Asp Thr Pro Thr Ser Pro Val Thr Ser Gly Leu Pro Leu Phe Phe 
                85                  90                  95      


Val Ile Thr Val Thr Ala Ile Lys Gln Gly Tyr Glu Asp Trp Leu Arg 
            100                 105                 110         


His Asn Ser Asp Asn Glu Val Asn Gly Ala Pro Val Tyr Val Val Arg 
        115                 120                 125             


Ser Gly Gly Leu Val Lys Thr Arg Ser Lys Asn Ile Arg Val Gly Asp 
    130                 135                 140                 


Ile Val Arg Ile Ala Lys Asp Glu Ile Phe Pro Ala Asp Leu Val Leu 
145                 150                 155                 160 


Leu Ser Ser Asp Arg Leu Asp Gly Ser Cys His Val Thr Thr Ala Ser 
                165                 170                 175     


Leu Asp Gly Glu Thr Asn Leu Lys Thr His Val Ala Val Pro Glu Thr 
            180                 185                 190         


Ala Leu Leu Gln Thr Val Ala Asn Leu Asp Thr Leu Val Ala Val Ile 
        195                 200                 205             


Glu Cys Gln Gln Pro Glu Ala Asp Leu Tyr Arg Phe Met Gly Arg Met 
    210                 215                 220                 


Ile Ile Thr Gln Gln Met Glu Glu Ile Val Arg Pro Leu Gly Pro Glu 
225                 230                 235                 240 


Ser Leu Leu Leu Arg Gly Ala Arg Leu Lys Asn Thr Lys Glu Ile Phe 
                245                 250                 255     


Gly Val Ala Val Tyr Thr Gly Met Glu Thr Lys Met Ala Leu Asn Tyr 
            260                 265                 270         


Lys Ser Lys Ser Gln Lys Arg Ser Ala Val Glu Lys Ser Met Asn Thr 
        275                 280                 285             


Phe Leu Ile Ile Tyr Leu Val Ile Leu Ile Ser Glu Ala Val Ile Ser 
    290                 295                 300                 


Thr Ile Leu Lys Tyr Thr Trp Gln Ala Glu Glu Lys Trp Asp Glu Pro 
305                 310                 315                 320 


Trp Tyr Asn Gln Lys Thr Glu His Gln Arg Asn Ser Ser Lys Ile Leu 
                325                 330                 335     


Arg Phe Ile Ser Asp Phe Leu Ala Phe Leu Val Leu Tyr Asn Phe Ile 
            340                 345                 350         


Ile Pro Ile Ser Leu Tyr Val Thr Val Glu Met Gln Lys Phe Leu Gly 
        355                 360                 365             


Ser Phe Phe Ile Gly Trp Asp Leu Asp Leu Tyr His Glu Glu Ser Asp 
    370                 375                 380                 


Gln Lys Ala Gln Val Asn Thr Ser Asp Leu Asn Glu Glu Leu Gly Gln 
385                 390                 395                 400 


Val Glu Tyr Val Phe Thr Asp Lys Thr Gly Thr Leu Thr Glu Asn Glu 
                405                 410                 415     


Met Gln Phe Arg Glu Cys Ser Ile Asn Gly Met Lys Tyr Gln Glu Ile 
            420                 425                 430         


Asn Gly Arg Leu Val Pro Glu Gly Pro Thr Pro Asp Ser Ser Glu Gly 
        435                 440                 445             


Asn Leu Ser Tyr Leu Ser Ser Leu Ser His Leu Asn Asn Leu Ser His 
    450                 455                 460                 


Leu Thr Thr Ser Ser Ser Phe Arg Thr Ser Pro Glu Asn Glu Thr Glu 
465                 470                 475                 480 


Leu Ile Lys Glu His Asp Leu Phe Phe Lys Ala Val Ser Leu Cys His 
                485                 490                 495     


Thr Val Gln Ile Ser Asn Val Gln Thr Asp Cys Thr Gly Asp Gly Pro 
            500                 505                 510         


Trp Gln Ser Asn Leu Ala Pro Ser Gln Leu Glu Tyr Tyr Ala Ser Ser 
        515                 520                 525             


Pro Asp Glu Lys Ala Leu Val Glu Ala Ala Ala Arg Ile Gly Ile Val 
    530                 535                 540                 


Phe Ile Gly Asn Ser Glu Glu Thr Met Glu Val Lys Thr Leu Gly Lys 
545                 550                 555                 560 


Leu Glu Arg Tyr Lys Leu Leu His Ile Leu Glu Phe Asp Ser Asp Arg 
                565                 570                 575     


Arg Arg Met Ser Val Ile Val Gln Ala Pro Ser Gly Glu Lys Leu Leu 
            580                 585                 590         


Phe Ala Lys Gly Ala Glu Ser Ser Ile Leu Pro Lys Cys Ile Gly Gly 
        595                 600                 605             


Glu Ile Glu Lys Thr Arg Ile His Val Asp Glu Phe Ala Leu Lys Gly 
    610                 615                 620                 


Leu Arg Thr Leu Cys Ile Ala Tyr Arg Lys Phe Thr Ser Lys Glu Tyr 
625                 630                 635                 640 


Glu Glu Ile Asp Lys Arg Ile Phe Glu Ala Arg Thr Ala Leu Gln Gln 
                645                 650                 655     


Arg Glu Glu Lys Leu Ala Ala Val Phe Gln Phe Ile Glu Lys Asp Leu 
            660                 665                 670         


Ile Leu Leu Gly Ala Thr Ala Val Glu Asp Arg Leu Gln Asp Lys Val 
        675                 680                 685             


Arg Glu Thr Ile Glu Ala Leu Arg Met Ala Gly Ile Lys Val Trp Val 
    690                 695                 700                 


Leu Thr Gly Asp Lys His Glu Thr Ala Val Ser Val Ser Leu Ser Cys 
705                 710                 715                 720 


Gly His Phe His Arg Thr Met Asn Ile Leu Glu Leu Ile Asn Gln Lys 
                725                 730                 735     


Ser Asp Ser Glu Cys Ala Glu Gln Leu Arg Gln Leu Ala Arg Arg Ile 
            740                 745                 750         


Thr Glu Asp His Val Ile Gln His Gly Leu Val Val Asp Gly Thr Ser 
        755                 760                 765             


Leu Ser Leu Ala Leu Arg Glu His Glu Lys Leu Phe Met Glu Val Cys 
    770                 775                 780                 


Arg Asn Cys Ser Ala Val Leu Cys Cys Arg Met Ala Pro Leu Gln Lys 
785                 790                 795                 800 


Ala Lys Val Ile Arg Leu Ile Lys Ile Ser Pro Glu Lys Pro Ile Thr 
                805                 810                 815     


Leu Ala Val Gly Asp Gly Ala Asn Asp Val Ser Met Ile Gln Glu Ala 
            820                 825                 830         


His Val Gly Ile Gly Ile Met Gly Lys Glu Gly Arg Gln Ala Ala Arg 
        835                 840                 845             


Asn Ser Asp Tyr Ala Ile Ala Arg Phe Lys Phe Leu Ser Lys Leu Leu 
    850                 855                 860                 


Phe Val His Gly His Phe Tyr Tyr Ile Arg Ile Ala Thr Leu Val Gln 
865                 870                 875                 880 


Tyr Phe Phe Tyr Lys Asn Val Cys Phe Ile Thr Pro Gln Phe Leu Tyr 
                885                 890                 895     


Gln Phe Tyr Cys Leu Phe Ser Gln Gln Thr Leu Tyr Asp Ser Val Tyr 
            900                 905                 910         


Leu Thr Leu Tyr Asn Ile Cys Phe Thr Ser Leu Pro Ile Leu Ile Tyr 
        915                 920                 925             


Ser Leu Leu Glu Gln His Val Asp Pro His Val Leu Gln Asn Lys Pro 
    930                 935                 940                 


Thr Leu Tyr Arg Asp Ile Ser Lys Asn Arg Leu Leu Ser Ile Lys Thr 
945                 950                 955                 960 


Phe Leu Tyr Trp Thr Ile Leu Gly Phe Ser His Ala Phe Ile Phe Phe 
                965                 970                 975     


Phe Gly Ser Tyr Leu Leu Ile Gly Lys Asp Thr Ser Leu Leu Gly Asn 
            980                 985                 990         


Gly Gln Met Phe Gly Asn Trp Thr  Phe Gly Thr Leu Val  Phe Thr Val 
        995                 1000                 1005             


Met Val  Ile Thr Val Thr Val  Lys Met Ala Leu Glu  Thr His Phe 
    1010                 1015                 1020             


Trp Thr  Trp Ile Asn His Leu  Val Thr Trp Gly Ser  Ile Ile Phe 
    1025                 1030                 1035             


Tyr Phe  Val Phe Ser Leu Phe  Tyr Gly Gly Ile Leu  Trp Pro Phe 
    1040                 1045                 1050             


Leu Gly  Ser Gln Asn Met Tyr  Phe Val Phe Ile Gln  Leu Leu Ser 
    1055                 1060                 1065             


Ser Gly  Ser Ala Trp Phe Ala  Ile Ile Leu Met Val  Val Thr Cys 
    1070                 1075                 1080             


Leu Phe  Leu Asp Ile Ile Lys  Lys Val Phe Asp Arg  His Leu His 
    1085                 1090                 1095             


Pro Thr  Ser Thr Glu Lys Ala  Gln Leu Thr Glu Thr  Asn Ala Gly 
    1100                 1105                 1110             


Ile Lys  Cys Leu Asp Ser Met  Cys Cys Phe Pro Glu  Gly Glu Ala 
    1115                 1120                 1125             


Ala Cys  Ala Ser Val Gly Arg  Met Leu Glu Arg Val  Ile Gly Arg 
    1130                 1135                 1140             


Cys Ser  Pro Thr His Ile Ser  Arg Ser Trp Ser Ala  Ser Asp Pro 
    1145                 1150                 1155             


Phe Tyr  Thr Asn Asp Arg Ser  Ile Leu Thr Leu Ser  Thr Met Asp 
    1160                 1165                 1170             


Ser Ser  Thr Cys 
    1175         


<210>  3965
<211>  956
<212>  PRT
<213>  Homo sapiens

<400>  3965

Met Pro Arg Val Ser Ala Pro Leu Val Leu Leu Pro Ala Trp Leu Val 
1               5                   10                  15      


Met Val Ala Cys Ser Pro His Ser Leu Arg Ile Ala Ala Ile Leu Asp 
            20                  25                  30          


Asp Pro Met Glu Cys Ser Arg Gly Glu Arg Leu Ser Ile Thr Leu Ala 
        35                  40                  45              


Lys Asn Arg Ile Asn Arg Ala Pro Glu Arg Leu Gly Lys Ala Lys Val 
    50                  55                  60                  


Glu Val Asp Ile Phe Glu Leu Leu Arg Asp Ser Glu Tyr Glu Thr Ala 
65                  70                  75                  80  


Glu Thr Met Cys Gln Ile Leu Pro Lys Gly Val Val Ala Val Leu Gly 
                85                  90                  95      


Pro Ser Ser Ser Pro Ala Ser Ser Ser Ile Ile Ser Asn Ile Cys Gly 
            100                 105                 110         


Glu Lys Glu Val Pro His Phe Lys Val Ala Pro Glu Glu Phe Val Lys 
        115                 120                 125             


Phe Gln Phe Gln Arg Phe Thr Thr Leu Asn Leu His Pro Ser Asn Thr 
    130                 135                 140                 


Asp Ile Ser Val Ala Val Ala Gly Ile Leu Asn Phe Phe Asn Cys Thr 
145                 150                 155                 160 


Thr Ala Cys Leu Ile Cys Ala Lys Ala Glu Cys Leu Leu Asn Leu Glu 
                165                 170                 175     


Lys Leu Leu Arg Gln Phe Leu Ile Ser Lys Asp Thr Leu Ser Val Arg 
            180                 185                 190         


Met Leu Asp Asp Thr Arg Asp Pro Thr Pro Leu Leu Lys Glu Ile Arg 
        195                 200                 205             


Asp Asp Lys Thr Ala Thr Ile Ile Ile His Ala Asn Ala Ser Met Ser 
    210                 215                 220                 


His Thr Ile Leu Leu Lys Ala Ala Glu Leu Gly Met Val Ser Ala Tyr 
225                 230                 235                 240 


Tyr Thr Tyr Ile Phe Thr Asn Leu Glu Phe Ser Leu Gln Arg Met Asp 
                245                 250                 255     


Ser Leu Val Asp Asp Arg Val Asn Ile Leu Gly Phe Ser Ile Phe Asn 
            260                 265                 270         


Gln Ser His Ala Phe Phe Gln Glu Phe Ala Gln Ser Leu Asn Gln Ser 
        275                 280                 285             


Trp Gln Glu Asn Cys Asp His Val Pro Phe Thr Gly Pro Ala Leu Ser 
    290                 295                 300                 


Ser Ala Leu Leu Phe Asp Ala Val Tyr Ala Val Val Thr Ala Val Gln 
305                 310                 315                 320 


Glu Leu Asn Arg Ser Gln Glu Ile Gly Val Lys Pro Leu Ser Cys Gly 
                325                 330                 335     


Ser Ala Gln Ile Trp Gln His Gly Thr Ser Leu Met Asn Tyr Leu Arg 
            340                 345                 350         


Met Val Glu Leu Glu Gly Leu Thr Gly His Ile Glu Phe Asn Ser Lys 
        355                 360                 365             


Gly Gln Arg Ser Asn Tyr Ala Leu Lys Ile Leu Gln Phe Thr Arg Asn 
    370                 375                 380                 


Gly Phe Arg Gln Ile Gly Gln Trp His Val Ala Glu Gly Leu Ser Met 
385                 390                 395                 400 


Asp Ser His Leu Tyr Ala Ser Asn Ile Ser Asp Thr Leu Phe Asn Thr 
                405                 410                 415     


Thr Leu Val Val Thr Thr Ile Leu Glu Asn Pro Tyr Leu Met Leu Lys 
            420                 425                 430         


Gly Asn His Gln Glu Met Glu Gly Asn Asp Arg Tyr Glu Gly Phe Cys 
        435                 440                 445             


Val Asp Met Leu Lys Glu Leu Ala Glu Ile Leu Arg Phe Asn Tyr Lys 
    450                 455                 460                 


Ile Arg Leu Val Gly Asp Gly Val Tyr Gly Val Pro Glu Ala Asn Gly 
465                 470                 475                 480 


Thr Trp Thr Gly Met Val Gly Glu Leu Ile Ala Arg Lys Ala Asp Leu 
                485                 490                 495     


Ala Val Ala Gly Leu Thr Ile Thr Ala Glu Arg Glu Lys Val Ile Asp 
            500                 505                 510         


Phe Ser Lys Pro Phe Met Thr Leu Gly Ile Ser Ile Leu Tyr Arg Val 
        515                 520                 525             


His Met Gly Arg Lys Pro Gly Tyr Phe Ser Phe Leu Asp Pro Phe Ser 
    530                 535                 540                 


Pro Gly Val Trp Leu Phe Met Leu Leu Ala Tyr Leu Ala Val Ser Cys 
545                 550                 555                 560 


Val Leu Phe Leu Val Ala Arg Leu Thr Pro Tyr Glu Trp Tyr Ser Pro 
                565                 570                 575     


His Pro Cys Ala Gln Gly Arg Cys Asn Leu Leu Val Asn Gln Tyr Ser 
            580                 585                 590         


Leu Gly Asn Ser Leu Trp Phe Pro Val Gly Gly Phe Met Gln Gln Gly 
        595                 600                 605             


Ser Thr Ile Ala Pro Arg Ala Leu Ser Thr Arg Cys Val Ser Gly Val 
    610                 615                 620                 


Trp Trp Ala Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu 
625                 630                 635                 640 


Ala Ala Phe Leu Thr Val Gln Arg Met Asp Val Pro Ile Glu Ser Val 
                645                 650                 655     


Asp Asp Leu Ala Asp Gln Thr Ala Ile Glu Tyr Gly Thr Ile His Gly 
            660                 665                 670         


Gly Ser Ser Met Thr Phe Phe Gln Asn Ser Arg Tyr Gln Thr Tyr Gln 
        675                 680                 685             


Arg Met Trp Asn Tyr Met Tyr Ser Lys Gln Pro Ser Val Phe Val Lys 
    690                 695                 700                 


Ser Thr Glu Glu Gly Ile Ala Arg Val Leu Asn Ser Asn Tyr Ala Phe 
705                 710                 715                 720 


Leu Leu Glu Ser Thr Met Asn Glu Tyr Tyr Arg Gln Arg Asn Cys Asn 
                725                 730                 735     


Leu Thr Gln Ile Gly Gly Leu Leu Asp Thr Lys Gly Tyr Gly Ile Gly 
            740                 745                 750         


Met Pro Val Gly Ser Val Phe Arg Asp Glu Phe Asp Leu Ala Ile Leu 
        755                 760                 765             


Gln Leu Gln Glu Asn Asn Arg Leu Glu Ile Leu Lys Arg Lys Trp Trp 
    770                 775                 780                 


Glu Gly Gly Lys Cys Pro Lys Glu Glu Asp His Arg Ala Lys Gly Leu 
785                 790                 795                 800 


Gly Met Glu Asn Ile Gly Gly Ile Phe Val Val Leu Ile Cys Gly Leu 
                805                 810                 815     


Ile Val Ala Ile Phe Met Ala Met Leu Glu Phe Leu Trp Thr Leu Arg 
            820                 825                 830         


His Ser Glu Ala Thr Glu Val Ser Val Cys Gln Glu Met Val Thr Glu 
        835                 840                 845             


Leu Arg Ser Ile Ile Leu Cys Gln Asp Ser Ile His Pro Arg Arg Arg 
    850                 855                 860                 


Arg Ala Ala Val Pro Pro Pro Arg Pro Pro Ile Pro Glu Glu Arg Arg 
865                 870                 875                 880 


Pro Arg Gly Thr Ala Thr Leu Ser Asn Gly Lys Leu Cys Gly Ala Gly 
                885                 890                 895     


Glu Pro Asp Gln Leu Ala Gln Arg Leu Ala Gln Glu Ala Ala Leu Val 
            900                 905                 910         


Ala Arg Gly Cys Thr His Ile Arg Val Cys Pro Glu Cys Arg Arg Phe 
        915                 920                 925             


Gln Gly Leu Arg Ala Arg Pro Ser Pro Ala Arg Ser Glu Glu Ser Leu 
    930                 935                 940                 


Glu Trp Glu Lys Thr Thr Asn Ser Ser Glu Pro Glu 
945                 950                 955     


<210>  3966
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  3966

Met Glu Arg Arg Ala Arg Ser Ser Ser Arg Glu Ser Arg Gly Arg Gly 
1               5                   10                  15      


Gly Arg Thr Pro His Lys Glu Asn Lys Arg Ala Lys Ala Glu Arg Ser 
            20                  25                  30          


Gly Gly Gly Arg Gly Arg Gln Glu Ala Gly Pro Glu Pro Ser Gly Ser 
        35                  40                  45              


Gly Arg Ala Gly Thr Pro Gly Glu Pro Arg Ala Pro Ala Ala Thr Val 
    50                  55                  60                  


Val Asp Val Asp Glu Val Arg Gly Ser Gly Glu Glu Gly Thr Glu Val 
65                  70                  75                  80  


Val Ala Leu Leu Glu Ser Glu Arg Pro Glu Glu Gly Thr Lys Ser Ser 
                85                  90                  95      


Gly Leu Gly Ala Cys Glu Trp Leu Leu Val Leu Ile Ser Leu Leu Phe 
            100                 105                 110         


Ile Ile Met Thr Phe Pro Phe Ser Ile Trp Phe Cys Val Lys Val Val 
        115                 120                 125             


Gln Glu Tyr Glu Arg Val Ile Ile Phe Arg Leu Gly His Leu Leu Pro 
    130                 135                 140                 


Gly Arg Ala Lys Gly Pro Gly Leu Phe Phe Phe Leu Pro Cys Leu Asp 
145                 150                 155                 160 


Thr Tyr His Lys Val Asp Leu Arg Leu Gln Thr Leu Glu Ile Pro Phe 
                165                 170                 175     


His Glu Ile Val Thr Lys Asp Met Phe Ile Met Glu Ile Asp Ala Ile 
            180                 185                 190         


Cys Tyr Tyr Arg Met Glu Asn Ala Ser Leu Leu Leu Ser Ser Leu Ala 
        195                 200                 205             


His Val Ser Lys Ala Val Gln Phe Leu Val Gln Thr Thr Met Lys Arg 
    210                 215                 220                 


Leu Leu Ala His Arg Ser Leu Thr Glu Ile Leu Leu Glu Arg Lys Ser 
225                 230                 235                 240 


Ile Ala Gln Asp Ala Lys Val Ala Leu Asp Ser Val Thr Cys Ile Trp 
                245                 250                 255     


Gly Ile Lys Val Glu Arg Ile Glu Ile Lys Asp Val Arg Leu Pro Ala 
            260                 265                 270         


Gly Leu Gln His Ser Leu Ala Val Glu Ala Glu Ala Gln Arg Gln Ala 
        275                 280                 285             


Lys Val Arg Met Ile Ala Ala Glu Ala Glu Lys Ala Ala Ser Glu Ser 
    290                 295                 300                 


Leu Arg Met Ala Ala Glu Ile Leu Ser Gly Thr Pro Ala Ala Val Gln 
305                 310                 315                 320 


Leu Arg Tyr Leu His Thr Leu Gln Ser Leu Ser Thr Glu Lys Pro Ser 
                325                 330                 335     


Thr Val Val Leu Pro Leu Pro Phe Asp Leu Leu Asn Cys Leu Ser Ser 
            340                 345                 350         


Pro Ser Asn Arg Thr Gln Gly Ser Leu Pro Phe Pro Ser Pro Ser Lys 
        355                 360                 365             


Pro Val Glu Pro Leu Asn Pro Lys Lys Lys Asp Ser Pro Met Leu 
    370                 375                 380             


<210>  3967
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  3967

Met Tyr Ser Phe Met Ala Gly Ser Ile Phe Ile Thr Ile Phe Gly Asn 
1               5                   10                  15      


Leu Ala Met Ile Ile Ser Ile Ser Tyr Phe Lys Gln Leu His Thr Pro 
            20                  25                  30          


Thr Asn Phe Leu Ile Leu Ser Met Ala Ile Thr Asp Phe Leu Leu Gly 
        35                  40                  45              


Phe Thr Ile Met Pro Tyr Ser Met Ile Arg Ser Val Glu Asn Cys Trp 
    50                  55                  60                  


Tyr Phe Gly Leu Thr Phe Cys Lys Ile Tyr Tyr Ser Phe Asp Leu Met 
65                  70                  75                  80  


Leu Ser Ile Thr Ser Ile Phe His Leu Cys Ser Val Ala Ile Asp Arg 
                85                  90                  95      


Phe Tyr Ala Ile Cys Tyr Pro Leu Leu Tyr Ser Thr Lys Ile Thr Ile 
            100                 105                 110         


Pro Val Ile Lys Arg Leu Leu Leu Leu Cys Trp Ser Val Pro Gly Ala 
        115                 120                 125             


Phe Ala Phe Gly Val Val Phe Ser Glu Ala Tyr Ala Asp Gly Ile Glu 
    130                 135                 140                 


Gly Tyr Asp Ile Leu Val Ala Cys Ser Ser Ser Cys Pro Val Met Phe 
145                 150                 155                 160 


Asn Lys Leu Trp Gly Thr Thr Leu Phe Met Ala Gly Phe Phe Thr Pro 
                165                 170                 175     


Gly Ser Met Met Val Gly Ile Tyr Gly Lys Ile Phe Ala Val Ser Arg 
            180                 185                 190         


Lys His Ala His Ala Ile Asn Asn Leu Arg Glu Asn Gln Asn Asn Gln 
        195                 200                 205             


Val Lys Lys Asp Lys Lys Ala Ala Lys Thr Leu Gly Ile Val Ile Gly 
    210                 215                 220                 


Val Phe Leu Leu Cys Trp Phe Pro Cys Phe Phe Thr Ile Leu Leu Asp 
225                 230                 235                 240 


Pro Phe Leu Asn Phe Ser Thr Pro Val Val Leu Phe Asp Ala Leu Thr 
                245                 250                 255     


Trp Phe Gly Tyr Phe Asn Ser Thr Cys Asn Pro Leu Ile Tyr Gly Phe 
            260                 265                 270         


Phe Tyr Pro Trp Phe Arg Arg Ala Leu Lys Tyr Ile Leu Leu Gly Lys 
        275                 280                 285             


Ile Phe Ser Ser Cys Phe His Asn Thr Ile Leu Cys Met Gln Lys Glu 
    290                 295                 300                 


Ser Glu 
305     


<210>  3968
<211>  565
<212>  PRT
<213>  Homo sapiens

<400>  3968

Met Ala Lys Leu Trp Phe Lys Phe Gln Arg Tyr Phe Arg Arg Lys Pro 
1               5                   10                  15      


Val Arg Phe Phe Thr Phe Leu Ala Leu Tyr Leu Thr Ala Gly Ser Leu 
            20                  25                  30          


Val Phe Leu His Ser Gly Phe Val Gly Gln Pro Ala Val Ser Gly Asn 
        35                  40                  45              


Gln Ala Asn Pro Ala Ala Ala Gly Gly Pro Ala Glu Gly Ala Glu Leu 
    50                  55                  60                  


Ser Phe Leu Gly Asp Met His Leu Gly Arg Gly Phe Arg Asp Thr Gly 
65                  70                  75                  80  


Glu Ala Ser Ser Ile Ala Arg Arg Tyr Gly Pro Trp Phe Lys Gly Lys 
                85                  90                  95      


Asp Gly Asn Glu Arg Ala Lys Leu Gly Asp Tyr Gly Gly Ala Trp Ser 
            100                 105                 110         


Arg Ala Leu Lys Gly Arg Val Val Arg Glu Lys Glu Glu Glu Arg Ala 
        115                 120                 125             


Lys Tyr Ile Gly Cys Tyr Leu Asp Asp Thr Gln Ser Arg Ala Leu Arg 
    130                 135                 140                 


Gly Val Ser Phe Phe Asp Tyr Lys Lys Met Thr Ile Phe Arg Cys Gln 
145                 150                 155                 160 


Asp Asn Cys Ala Glu Arg Gly Tyr Leu Tyr Gly Gly Leu Glu Phe Gly 
                165                 170                 175     


Ala Glu Cys Tyr Cys Gly His Lys Ile Gln Ala Thr Asn Val Ser Glu 
            180                 185                 190         


Ala Glu Cys Asp Met Glu Cys Lys Gly Glu Arg Gly Ser Val Cys Gly 
        195                 200                 205             


Gly Ala Asn Arg Leu Ser Val Tyr Arg Leu Gln Leu Ala Gln Glu Ser 
    210                 215                 220                 


Ala Arg Arg Tyr Gly Ser Ala Val Phe Arg Gly Cys Phe Arg Arg Pro 
225                 230                 235                 240 


Asp Asn Leu Ser Leu Ala Leu Pro Val Thr Ala Ala Met Leu Asn Met 
                245                 250                 255     


Ser Val Asp Lys Cys Val Asp Phe Cys Thr Glu Lys Glu Tyr Pro Leu 
            260                 265                 270         


Ala Ala Leu Ala Gly Thr Ala Cys His Cys Gly Phe Pro Thr Thr Arg 
        275                 280                 285             


Phe Pro Leu His Asp Arg Glu Asp Glu Gln Leu Cys Ala Gln Lys Cys 
    290                 295                 300                 


Ser Ala Glu Glu Phe Glu Ser Cys Gly Thr Pro Ser Tyr Phe Ile Val 
305                 310                 315                 320 


Tyr Gln Thr Gln Val Gln Asp Asn Arg Cys Met Asp Arg Arg Phe Leu 
                325                 330                 335     


Pro Gly Lys Ser Lys Gln Leu Ile Ala Leu Ala Ser Phe Pro Gly Ala 
            340                 345                 350         


Gly Asn Thr Trp Ala Arg His Leu Ile Glu Leu Ala Thr Gly Phe Tyr 
        355                 360                 365             


Thr Gly Ser Tyr Tyr Phe Asp Gly Ser Leu Tyr Asn Lys Gly Phe Lys 
    370                 375                 380                 


Gly Glu Arg Asp His Trp Arg Ser Gly Arg Thr Ile Cys Ile Lys Thr 
385                 390                 395                 400 


His Glu Ser Gly Gln Lys Glu Ile Glu Ala Phe Asp Ala Ala Ile Leu 
                405                 410                 415     


Leu Ile Arg Asn Pro Tyr Lys Ala Leu Met Ala Glu Phe Asn Arg Lys 
            420                 425                 430         


Tyr Gly Gly His Ile Gly Phe Ala Ala His Ala His Trp Lys Gly Lys 
        435                 440                 445             


Glu Trp Pro Glu Phe Val Arg Asn Tyr Ala Pro Trp Trp Ala Thr His 
    450                 455                 460                 


Thr Leu Asp Trp Leu Lys Phe Gly Lys Lys Val Leu Val Val His Phe 
465                 470                 475                 480 


Glu Asp Leu Lys Gln Asp Leu Phe Val Gln Leu Gly Arg Met Val Ser 
                485                 490                 495     


Leu Leu Gly Val Ala Val Arg Glu Asp Arg Leu Leu Cys Val Glu Ser 
            500                 505                 510         


Gln Lys Asp Gly Asn Phe Lys Arg Ser Gly Leu Arg Lys Leu Glu Tyr 
        515                 520                 525             


Asp Pro Tyr Thr Ala Asp Met Gln Lys Thr Ile Ser Ala Tyr Ile Lys 
    530                 535                 540                 


Met Val Asp Ala Ala Leu Lys Gly Arg Asn Leu Thr Gly Val Pro Asp 
545                 550                 555                 560 


Asp Tyr Tyr Pro Arg 
                565 


<210>  3969
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  3969

Met Lys Pro Gly Pro Pro His Arg Ala Gly Ala Ala His Gly Ala Gly 
1               5                   10                  15      


Ala Gly Ala Gly Ala Ala Ala Gly Pro Gly Ala Arg Gly Leu Leu Leu 
            20                  25                  30          


Pro Pro Leu Leu Leu Leu Leu Leu Ala Gly Arg Ala Ala Gly Ala Gln 
        35                  40                  45              


Arg Trp Arg Ser Glu Asn Phe Glu Arg Pro Val Asp Leu Glu Gly Ser 
    50                  55                  60                  


Gly Asp Asp Asp Ser Phe Pro Asp Asp Glu Leu Asp Asp Leu Tyr Ser 
65                  70                  75                  80  


Gly Ser Gly Ser Gly Tyr Phe Glu Gln Glu Ser Gly Ile Glu Thr Ala 
                85                  90                  95      


Met Arg Phe Ser Pro Asp Val Ala Leu Ala Val Ser Thr Thr Pro Ala 
            100                 105                 110         


Val Leu Pro Thr Thr Asn Ile Gln Pro Val Gly Thr Pro Phe Glu Glu 
        115                 120                 125             


Leu Pro Ser Glu Arg Pro Thr Leu Glu Pro Ala Thr Ser Pro Leu Val 
    130                 135                 140                 


Val Thr Glu Val Pro Glu Glu Pro Ser Gln Arg Ala Thr Thr Val Ser 
145                 150                 155                 160 


Thr Thr Met Ala Thr Thr Ala Ala Thr Ser Thr Gly Asp Pro Thr Val 
                165                 170                 175     


Ala Thr Val Pro Ala Thr Val Ala Thr Ala Thr Pro Ser Thr Pro Ala 
            180                 185                 190         


Ala Pro Pro Phe Thr Ala Thr Thr Ala Val Ile Arg Thr Thr Gly Val 
        195                 200                 205             


Arg Arg Leu Leu Pro Leu Pro Leu Thr Thr Val Ala Thr Ala Arg Ala 
    210                 215                 220                 


Thr Thr Pro Glu Ala Pro Ser Pro Pro Thr Thr Ala Ala Val Leu Asp 
225                 230                 235                 240 


Thr Glu Ala Pro Thr Pro Arg Leu Val Ser Thr Ala Thr Ser Arg Pro 
                245                 250                 255     


Arg Ala Leu Pro Arg Pro Ala Thr Thr Gln Glu Pro Asp Ile Pro Glu 
            260                 265                 270         


Arg Ser Thr Leu Pro Leu Gly Thr Thr Ala Pro Gly Pro Thr Glu Val 
        275                 280                 285             


Ala Gln Thr Pro Thr Pro Glu Thr Phe Leu Thr Thr Ile Arg Asp Glu 
    290                 295                 300                 


Pro Glu Val Pro Val Ser Gly Gly Pro Ser Gly Asp Phe Glu Leu Pro 
305                 310                 315                 320 


Glu Glu Glu Thr Thr Gln Pro Asp Thr Ala Asn Glu Val Val Ala Val 
                325                 330                 335     


Gly Gly Ala Ala Ala Lys Ala Ser Ser Pro Pro Gly Thr Leu Pro Lys 
            340                 345                 350         


Gly Ala Arg Pro Gly Pro Gly Leu Leu Asp Asn Ala Ile Asp Ser Gly 
        355                 360                 365             


Ser Ser Ala Ala Gln Leu Pro Gln Lys Ser Ile Leu Glu Arg Lys Glu 
    370                 375                 380                 


Val Leu Val Ala Val Ile Val Gly Gly Val Val Gly Ala Leu Phe Ala 
385                 390                 395                 400 


Ala Phe Leu Val Thr Leu Leu Ile Tyr Arg Met Lys Lys Lys Asp Glu 
                405                 410                 415     


Gly Ser Tyr Thr Leu Glu Glu Pro Lys Gln Ala Ser Val Thr Tyr Gln 
            420                 425                 430         


Lys Pro Asp Lys Gln Glu Glu Phe Tyr Ala 
        435                 440         


<210>  3970
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  3970

Met Glu Asp Lys Arg Asn Ile Gln Ile Ile Glu Trp Glu His Leu Asp 
1               5                   10                  15      


Lys Lys Lys Phe Tyr Val Phe Gly Val Ala Met Thr Met Met Ile Arg 
            20                  25                  30          


Val Ser Val Tyr Pro Phe Thr Leu Ile Arg Thr Arg Leu Gln Val Gln 
        35                  40                  45              


Lys Gly Lys Ser Leu Tyr His Gly Thr Phe Asp Ala Phe Ile Lys Ile 
    50                  55                  60                  


Leu Arg Ala Asp Gly Ile Thr Gly Leu Tyr Arg Gly Phe Leu Val Asn 
65                  70                  75                  80  


Thr Phe Thr Leu Ile Ser Gly Gln Cys Tyr Val Thr Thr Tyr Glu Leu 
                85                  90                  95      


Thr Arg Lys Phe Val Ala Asp Tyr Ser Gln Ser Asn Thr Val Lys Ser 
            100                 105                 110         


Leu Val Ala Gly Gly Ser Ala Ser Leu Val Ala Gln Ser Ile Thr Val 
        115                 120                 125             


Pro Ile Asp Val Val Ser Gln His Leu Met Met Gln Arg Lys Gly Glu 
    130                 135                 140                 


Lys Met Gly Arg Phe Gln Val Arg Gly Asn Pro Glu Gly Gln Gly Val 
145                 150                 155                 160 


Val Ala Phe Gly Gln Thr Lys Asp Ile Ile Arg Gln Ile Leu Gln Ala 
                165                 170                 175     


Asp Gly Leu Arg Gly Phe Tyr Arg Gly Tyr Val Ala Ser Leu Leu Thr 
            180                 185                 190         


Tyr Ile Pro Asn Ser Ala Val Trp Trp Pro Phe Tyr His Phe Tyr Ala 
        195                 200                 205             


Glu Gln Leu Ser Tyr Leu Cys Pro Lys Glu Cys Pro His Ile Val Phe 
    210                 215                 220                 


Gln Ala Val Ser Gly Pro Leu Ala Ala Ala Thr Ala Ser Ile Leu Thr 
225                 230                 235                 240 


Asn Pro Met Asp Val Ile Arg Thr Arg Val Gln Val Glu Gly Lys Asn 
                245                 250                 255     


Ser Ile Ile Leu Thr Phe Arg Gln Leu Met Ala Glu Glu Gly Pro Trp 
            260                 265                 270         


Gly Leu Met Lys Gly Leu Ser Ala Arg Ile Ile Ser Ala Thr Pro Ser 
        275                 280                 285             


Thr Ile Val Ile Val Val Gly Tyr Glu Ser Leu Lys Lys Leu Ser Leu 
    290                 295                 300                 


Arg Pro Glu Leu Val Asp Ser Arg His Trp 
305                 310                 


<210>  3971
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  3971

Met Glu Arg Ile Ser Ala Phe Phe Ser Ser Ile Trp Asp Thr Ile Leu 
1               5                   10                  15      


Thr Lys His Gln Glu Gly Ile Tyr Asn Thr Ile Cys Leu Gly Val Leu 
            20                  25                  30          


Leu Gly Leu Pro Leu Leu Val Ile Ile Thr Leu Leu Phe Ile Cys Cys 
        35                  40                  45              


His Cys Cys Trp Ser Pro Pro Gly Lys Arg Gly Gln Gln Pro Glu Lys 
    50                  55                  60                  


Asn Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Asp Glu Glu Asp Leu 
65                  70                  75                  80  


Trp Ile Ser Ala Gln Pro Lys Leu Leu Gln Met Glu Lys Arg Pro Ser 
                85                  90                  95      


Leu Pro Val 
            


<210>  3972
<211>  657
<212>  PRT
<213>  Homo sapiens

<400>  3972

Met Gln Trp Arg Ala Leu Val Leu Gly Leu Val Leu Leu Arg Leu Gly 
1               5                   10                  15      


Leu His Gly Val Leu Trp Leu Val Phe Gly Leu Gly Pro Ser Met Gly 
            20                  25                  30          


Phe Tyr Gln Arg Phe Pro Leu Ser Phe Gly Phe Gln Arg Leu Arg Ser 
        35                  40                  45              


Pro Asp Gly Pro Ala Ser Pro Thr Ser Gly Pro Val Gly Arg Pro Gly 
    50                  55                  60                  


Gly Val Ser Gly Pro Ser Trp Leu Gln Pro Pro Gly Thr Gly Ala Ala 
65                  70                  75                  80  


Gln Ser Pro Arg Lys Ala Pro Arg Arg Pro Gly Pro Gly Met Cys Gly 
                85                  90                  95      


Pro Ala Asn Trp Gly Tyr Val Leu Gly Gly Arg Gly Arg Gly Pro Asp 
            100                 105                 110         


Glu Tyr Glu Lys Arg Tyr Ser Gly Ala Phe Pro Pro Gln Leu Arg Ala 
        115                 120                 125             


Gln Met Arg Asp Leu Ala Arg Gly Met Phe Val Phe Gly Tyr Asp Asn 
    130                 135                 140                 


Tyr Met Ala His Ala Phe Pro Gln Asp Glu Leu Asn Pro Ile His Cys 
145                 150                 155                 160 


Arg Gly Arg Gly Pro Asp Arg Gly Asp Pro Ser Asn Leu Asn Ile Asn 
                165                 170                 175     


Asp Val Leu Gly Asn Tyr Ser Leu Thr Leu Val Asp Ala Leu Asp Thr 
            180                 185                 190         


Leu Ala Ile Met Gly Asn Ser Ser Glu Phe Gln Lys Ala Val Lys Leu 
        195                 200                 205             


Val Ile Asn Thr Val Ser Phe Asp Lys Asp Ser Thr Val Gln Val Phe 
    210                 215                 220                 


Glu Ala Thr Ile Arg Val Leu Gly Ser Leu Leu Ser Ala His Arg Ile 
225                 230                 235                 240 


Ile Thr Asp Ser Lys Gln Pro Phe Gly Asp Met Thr Ile Lys Asp Tyr 
                245                 250                 255     


Asp Asn Glu Leu Leu Tyr Met Ala His Asp Leu Ala Val Arg Leu Leu 
            260                 265                 270         


Pro Ala Phe Glu Asn Thr Lys Thr Gly Ile Pro Tyr Pro Arg Val Asn 
        275                 280                 285             


Leu Lys Thr Gly Val Pro Pro Asp Thr Asn Asn Glu Thr Cys Thr Ala 
    290                 295                 300                 


Gly Ala Gly Ser Leu Leu Val Glu Phe Gly Ile Leu Ser Arg Leu Leu 
305                 310                 315                 320 


Gly Asp Ser Thr Phe Glu Trp Val Ala Arg Arg Ala Val Lys Ala Leu 
                325                 330                 335     


Trp Asn Leu Arg Ser Asn Asp Thr Gly Leu Leu Gly Asn Val Val Asn 
            340                 345                 350         


Ile Gln Thr Gly His Trp Val Gly Lys Gln Ser Gly Leu Gly Ala Gly 
        355                 360                 365             


Leu Asp Ser Phe Tyr Glu Tyr Leu Leu Lys Ser Tyr Ile Leu Phe Gly 
    370                 375                 380                 


Glu Lys Glu Asp Leu Glu Met Phe Asn Ala Ala Tyr Gln Ser Ile Gln 
385                 390                 395                 400 


Asn Tyr Leu Arg Arg Gly Arg Glu Ala Cys Asn Glu Gly Glu Gly Asp 
                405                 410                 415     


Pro Pro Leu Tyr Val Asn Val Asn Met Phe Ser Gly Gln Leu Met Asn 
            420                 425                 430         


Thr Trp Ile Asp Ser Leu Gln Ala Phe Phe Pro Gly Leu Gln Val Leu 
        435                 440                 445             


Ile Gly Asp Val Glu Asp Ala Ile Cys Leu His Ala Phe Tyr Tyr Ala 
    450                 455                 460                 


Ile Trp Lys Arg Tyr Gly Ala Leu Pro Glu Arg Tyr Asn Trp Gln Leu 
465                 470                 475                 480 


Gln Ala Pro Asp Val Leu Phe Tyr Pro Leu Arg Pro Glu Leu Val Glu 
                485                 490                 495     


Ser Thr Tyr Leu Leu Tyr Gln Ala Thr Lys Asn Pro Phe Tyr Leu His 
            500                 505                 510         


Val Gly Met Asp Ile Leu Gln Ser Leu Glu Lys Tyr Thr Lys Val Lys 
        515                 520                 525             


Cys Gly Tyr Ala Thr Leu His His Val Ile Asp Lys Ser Thr Glu Asp 
    530                 535                 540                 


Arg Met Glu Ser Phe Phe Leu Ser Glu Thr Cys Lys Tyr Leu Tyr Leu 
545                 550                 555                 560 


Leu Phe Asp Glu Asp Asn Pro Val His Lys Ser Gly Thr Arg Tyr Met 
                565                 570                 575     


Phe Thr Thr Glu Gly His Ile Val Ser Val Asp Glu His Leu Arg Glu 
            580                 585                 590         


Leu Pro Trp Lys Glu Phe Phe Ser Glu Glu Gly Gly Gln Asp Gln Gly 
        595                 600                 605             


Gly Lys Ser Val His Arg Pro Lys Pro His Glu Leu Lys Val Ile Asn 
    610                 615                 620                 


Ser Ser Ser Asn Cys Asn Arg Val Pro Asp Glu Arg Arg Tyr Ser Leu 
625                 630                 635                 640 


Pro Leu Lys Ser Ile Tyr Met Arg Gln Ile Asp Gln Met Val Gly Leu 
                645                 650                 655     


Ile 
    


<210>  3973
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  3973

Met Glu Ser Glu Thr Glu Pro Glu Pro Val Thr Leu Leu Val Lys Ser 
1               5                   10                  15      


Pro Asn Gln Arg His Arg Asp Leu Glu Leu Ser Gly Asp Arg Gly Trp 
            20                  25                  30          


Ser Val Gly His Leu Lys Ala His Leu Ser Arg Val Tyr Pro Glu Arg 
        35                  40                  45              


Pro Arg Pro Glu Asp Gln Arg Leu Ile Tyr Ser Gly Lys Leu Leu Leu 
    50                  55                  60                  


Asp His Gln Cys Leu Arg Asp Leu Leu Pro Lys Gln Glu Lys Arg His 
65                  70                  75                  80  


Val Leu His Leu Val Cys Asn Val Lys Ser Pro Ser Lys Met Pro Glu 
                85                  90                  95      


Ile Asn Ala Lys Val Ala Glu Ser Thr Glu Glu Pro Ala Gly Ser Asn 
            100                 105                 110         


Arg Gly Gln Tyr Pro Glu Asp Ser Ser Ser Asp Gly Leu Arg Gln Arg 
        115                 120                 125             


Glu Val Leu Arg Asn Leu Ser Ser Pro Gly Trp Glu Asn Ile Ser Arg 
    130                 135                 140                 


Pro Glu Ala Ala Gln Gln Ala Phe Gln Gly Leu Gly Pro Gly Phe Ser 
145                 150                 155                 160 


Gly Tyr Thr Pro Tyr Gly Trp Leu Gln Leu Ser Trp Phe Gln Gln Ile 
                165                 170                 175     


Tyr Ala Arg Gln Tyr Tyr Met Gln Tyr Leu Ala Ala Thr Ala Ala Ser 
            180                 185                 190         


Gly Ala Phe Val Pro Pro Pro Ser Ala Gln Glu Ile Pro Val Val Ser 
        195                 200                 205             


Ala Pro Ala Pro Ala Pro Ile His Asn Gln Phe Pro Ala Glu Asn Gln 
    210                 215                 220                 


Pro Ala Asn Gln Asn Ala Ala Pro Gln Val Val Val Asn Pro Gly Ala 
225                 230                 235                 240 


Asn Gln Asn Leu Arg Met Asn Ala Gln Gly Gly Pro Ile Val Glu Glu 
                245                 250                 255     


Asp Asp Glu Ile Asn Arg Asp Trp Leu Asp Trp Thr Tyr Ser Ala Ala 
            260                 265                 270         


Thr Phe Ser Val Phe Leu Ser Ile Leu Tyr Phe Tyr Ser Ser Leu Ser 
        275                 280                 285             


Arg Phe Leu Met Val Met Gly Ala Thr Val Val Met Tyr Leu His His 
    290                 295                 300                 


Val Gly Trp Phe Pro Phe Arg Pro Arg Pro Val Gln Asn Phe Pro Asn 
305                 310                 315                 320 


Asp Gly Pro Pro Pro Asp Val Val Asn Gln Asp Pro Asn Asn Asn Leu 
                325                 330                 335     


Gln Glu Gly Thr Asp Pro Glu Thr Glu Asp Pro Asn His Leu Pro Pro 
            340                 345                 350         


Asp Arg Asp Val Leu Asp Gly Glu Gln Thr Ser Pro Ser Phe Met Ser 
        355                 360                 365             


Thr Ala Trp Leu Val Phe Lys Thr Phe Phe Ala Ser Leu Leu Pro Glu 
    370                 375                 380                 


Gly Pro Pro Ala Ile Ala Asn 
385                 390     


<210>  3974
<211>  883
<212>  PRT
<213>  Homo sapiens

<400>  3974

Met Ala Ser Pro Gly Ala Gly Arg Ala Pro Pro Glu Leu Pro Glu Arg 
1               5                   10                  15      


Asn Cys Gly Tyr Arg Glu Val Glu Tyr Trp Asp Gln Arg Tyr Gln Gly 
            20                  25                  30          


Ala Ala Asp Ser Ala Pro Tyr Asp Trp Phe Gly Asp Phe Ser Ser Phe 
        35                  40                  45              


Arg Ala Leu Leu Glu Pro Glu Leu Arg Pro Glu Asp Arg Ile Leu Val 
    50                  55                  60                  


Leu Gly Cys Gly Asn Ser Ala Leu Ser Tyr Glu Leu Phe Leu Gly Gly 
65                  70                  75                  80  


Phe Pro Asn Val Thr Ser Val Asp Tyr Ser Ser Val Val Val Ala Ala 
                85                  90                  95      


Met Gln Ala Arg His Ala His Val Pro Gln Leu Arg Trp Glu Thr Met 
            100                 105                 110         


Asp Val Arg Lys Leu Asp Phe Pro Ser Ala Ser Phe Asp Val Val Leu 
        115                 120                 125             


Glu Lys Gly Thr Leu Asp Ala Leu Leu Ala Gly Glu Arg Asp Pro Trp 
    130                 135                 140                 


Thr Val Ser Ser Glu Gly Val His Thr Val Asp Gln Val Leu Ser Glu 
145                 150                 155                 160 


Val Gly Phe Gln Lys Gly Thr Arg Gln Leu Leu Gly Ser Arg Thr Gln 
                165                 170                 175     


Leu Glu Leu Val Leu Ala Gly Ala Ser Leu Leu Leu Ala Ala Leu Leu 
            180                 185                 190         


Leu Gly Cys Leu Val Ala Leu Gly Val Gln Tyr His Arg Asp Pro Ser 
        195                 200                 205             


His Ser Thr Cys Leu Thr Glu Ala Cys Ile Arg Val Ala Gly Lys Ile 
    210                 215                 220                 


Leu Glu Ser Leu Asp Arg Gly Val Ser Pro Cys Glu Asp Phe Tyr Gln 
225                 230                 235                 240 


Phe Ser Cys Gly Gly Trp Ile Arg Arg Asn Pro Leu Pro Asp Gly Arg 
                245                 250                 255     


Ser Arg Trp Asn Thr Phe Asn Ser Leu Trp Asp Gln Asn Gln Ala Ile 
            260                 265                 270         


Leu Lys His Leu Leu Glu Asn Thr Thr Phe Asn Ser Ser Ser Glu Ala 
        275                 280                 285             


Glu Gln Lys Thr Gln Arg Phe Tyr Leu Ser Cys Leu Gln Val Glu Arg 
    290                 295                 300                 


Ile Glu Glu Leu Gly Ala Gln Pro Leu Arg Asp Leu Ile Glu Lys Ile 
305                 310                 315                 320 


Gly Gly Trp Asn Ile Thr Gly Pro Trp Asp Gln Asp Asn Phe Met Glu 
                325                 330                 335     


Val Leu Lys Ala Val Ala Gly Thr Tyr Arg Ala Thr Pro Phe Phe Thr 
            340                 345                 350         


Val Tyr Ile Ser Ala Asp Ser Lys Ser Ser Asn Ser Asn Val Ile Gln 
        355                 360                 365             


Val Asp Gln Ser Gly Leu Phe Leu Pro Ser Arg Asp Tyr Tyr Leu Asn 
    370                 375                 380                 


Arg Thr Ala Asn Glu Lys Val Leu Thr Ala Tyr Leu Asp Tyr Met Glu 
385                 390                 395                 400 


Glu Leu Gly Met Leu Leu Gly Gly Arg Pro Thr Ser Thr Arg Glu Gln 
                405                 410                 415     


Met Gln Gln Val Leu Glu Leu Glu Ile Gln Leu Ala Asn Ile Thr Val 
            420                 425                 430         


Pro Gln Asp Gln Arg Arg Asp Glu Glu Lys Ile Tyr His Lys Met Ser 
        435                 440                 445             


Ile Ser Glu Leu Gln Ala Leu Ala Pro Ser Met Asp Trp Leu Glu Phe 
    450                 455                 460                 


Leu Ser Phe Leu Leu Ser Pro Leu Glu Leu Ser Asp Ser Glu Pro Val 
465                 470                 475                 480 


Val Val Tyr Gly Met Asp Tyr Leu Gln Gln Val Ser Glu Leu Ile Asn 
                485                 490                 495     


Arg Thr Glu Pro Ser Ile Leu Asn Asn Tyr Leu Ile Trp Asn Leu Val 
            500                 505                 510         


Gln Lys Thr Thr Ser Ser Leu Asp Arg Arg Phe Glu Ser Ala Gln Glu 
        515                 520                 525             


Lys Leu Leu Glu Thr Leu Tyr Gly Thr Lys Lys Ser Cys Val Pro Arg 
    530                 535                 540                 


Trp Gln Thr Cys Ile Ser Asn Thr Asp Asp Ala Leu Gly Phe Ala Leu 
545                 550                 555                 560 


Gly Ser Leu Phe Val Lys Ala Thr Phe Asp Arg Gln Ser Lys Glu Ile 
                565                 570                 575     


Ala Glu Gly Met Ile Ser Glu Ile Arg Thr Ala Phe Glu Glu Ala Leu 
            580                 585                 590         


Gly Gln Leu Val Trp Met Asp Glu Lys Thr Arg Gln Ala Ala Lys Glu 
        595                 600                 605             


Lys Ala Asp Ala Ile Tyr Asp Met Ile Gly Phe Pro Asp Phe Ile Leu 
    610                 615                 620                 


Glu Pro Lys Glu Leu Asp Asp Val Tyr Asp Gly Tyr Glu Ile Ser Glu 
625                 630                 635                 640 


Asp Ser Phe Phe Gln Asn Met Leu Asn Leu Tyr Asn Phe Ser Ala Lys 
                645                 650                 655     


Val Met Ala Asp Gln Leu Arg Lys Pro Pro Ser Arg Asp Gln Trp Ser 
            660                 665                 670         


Met Thr Pro Gln Thr Val Asn Ala Tyr Tyr Leu Pro Thr Lys Asn Glu 
        675                 680                 685             


Ile Val Phe Pro Ala Gly Ile Leu Gln Ala Pro Phe Tyr Ala Arg Asn 
    690                 695                 700                 


His Pro Lys Ala Leu Asn Phe Gly Gly Ile Gly Val Val Met Gly His 
705                 710                 715                 720 


Glu Leu Thr His Ala Phe Asp Asp Gln Gly Arg Glu Tyr Asp Lys Glu 
                725                 730                 735     


Gly Asn Leu Arg Pro Trp Trp Gln Asn Glu Ser Leu Ala Ala Phe Arg 
            740                 745                 750         


Asn His Thr Ala Cys Met Glu Glu Gln Tyr Asn Gln Tyr Gln Val Asn 
        755                 760                 765             


Gly Glu Arg Leu Asn Gly Arg Gln Thr Leu Gly Glu Asn Ile Ala Asp 
    770                 775                 780                 


Asn Gly Gly Leu Lys Ala Ala Tyr Asn Ala Tyr Lys Ala Trp Leu Arg 
785                 790                 795                 800 


Lys His Gly Glu Glu Gln Gln Leu Pro Ala Val Gly Leu Thr Asn His 
                805                 810                 815     


Gln Leu Phe Phe Val Gly Phe Ala Gln Val Trp Cys Ser Val Arg Thr 
            820                 825                 830         


Pro Glu Ser Ser His Glu Gly Leu Val Thr Asp Pro His Ser Pro Ala 
        835                 840                 845             


Arg Phe Arg Val Leu Gly Thr Leu Ser Asn Ser Arg Asp Phe Leu Arg 
    850                 855                 860                 


His Phe Gly Cys Pro Val Gly Ser Pro Met Asn Pro Gly Gln Leu Cys 
865                 870                 875                 880 


Glu Val Trp 
            


<210>  3975
<211>  807
<212>  PRT
<213>  Homo sapiens

<400>  3975

Met Met Asp Ser Pro Phe Leu Glu Leu Trp Gln Ser Lys Ala Val Ser 
1               5                   10                  15      


Ile Arg Glu Gln Leu Gly Leu Gly Asp Arg Pro Asn Asp Ser Tyr Cys 
            20                  25                  30          


Tyr Asn Ser Ala Lys Asn Ser Thr Val Leu Gln Gly Val Thr Phe Gly 
        35                  40                  45              


Gly Ile Pro Thr Val Leu Leu Ile Asp Val Ser Cys Phe Leu Phe Leu 
    50                  55                  60                  


Ile Leu Val Phe Ser Ile Ile Arg Arg Arg Phe Trp Asp Tyr Gly Arg 
65                  70                  75                  80  


Ile Ala Leu Val Ser Glu Ala Asp Ser Glu Ser Arg Phe Gln Arg Leu 
                85                  90                  95      


Ser Ser Thr Ser Ser Ser Gly Gln Gln Asp Phe Glu Asn Glu Leu Gly 
            100                 105                 110         


Cys Cys Pro Trp Leu Thr Ala Ile Phe Arg Leu His Asp Asp Gln Ile 
        115                 120                 125             


Leu Glu Trp Cys Gly Glu Asp Ala Ile His Tyr Leu Ser Phe Gln Arg 
    130                 135                 140                 


His Ile Ile Phe Leu Leu Val Val Val Ser Phe Leu Ser Leu Cys Val 
145                 150                 155                 160 


Ile Leu Pro Val Asn Leu Ser Gly Asp Leu Leu Asp Lys Asp Pro Tyr 
                165                 170                 175     


Ser Phe Gly Arg Thr Thr Ile Ala Asn Leu Gln Thr Asp Asn Asp Leu 
            180                 185                 190         


Leu Trp Leu His Thr Ile Phe Ala Val Ile Tyr Leu Phe Leu Thr Val 
        195                 200                 205             


Gly Phe Met Arg His His Thr Gln Ser Ile Lys Tyr Lys Glu Glu Asn 
    210                 215                 220                 


Leu Val Arg Arg Thr Leu Phe Ile Thr Gly Leu Pro Arg Asp Ala Arg 
225                 230                 235                 240 


Lys Glu Thr Val Glu Ser His Phe Arg Asp Ala Tyr Pro Thr Cys Glu 
                245                 250                 255     


Val Val Asp Val Gln Leu Cys Tyr Asn Val Ala Lys Leu Ile Tyr Leu 
            260                 265                 270         


Cys Lys Glu Lys Lys Lys Thr Glu Lys Ser Leu Thr Tyr Tyr Thr Asn 
        275                 280                 285             


Leu Gln Val Lys Thr Gly Gln Arg Thr Leu Ile Asn Pro Lys Pro Cys 
    290                 295                 300                 


Gly Gln Phe Cys Cys Cys Glu Val Leu Gly Cys Glu Trp Glu Asp Ala 
305                 310                 315                 320 


Ile Ser Tyr Tyr Thr Arg Met Lys Asp Arg Leu Leu Glu Arg Ile Thr 
                325                 330                 335     


Glu Glu Glu Arg His Val Gln Asp Gln Pro Leu Gly Met Ala Phe Val 
            340                 345                 350         


Thr Phe Gln Glu Lys Ser Met Ala Thr Tyr Ile Leu Lys Asp Phe Asn 
        355                 360                 365             


Ala Cys Lys Cys Gln Ser Leu Gln Cys Lys Gly Glu Pro Gln Pro Ser 
    370                 375                 380                 


Ser His Ser Arg Glu Leu Tyr Thr Ser Lys Trp Thr Val Thr Phe Ala 
385                 390                 395                 400 


Ala Asp Pro Glu Asp Ile Cys Trp Lys Asn Leu Ser Ile Gln Gly Leu 
                405                 410                 415     


Arg Trp Trp Leu Gln Trp Leu Gly Ile Asn Phe Thr Leu Phe Leu Gly 
            420                 425                 430         


Leu Phe Phe Leu Thr Thr Pro Ser Ile Ile Leu Ser Thr Met Asp Lys 
        435                 440                 445             


Phe Asn Val Thr Lys Pro Ile His Ala Leu Asn Asn Pro Ile Ile Ser 
    450                 455                 460                 


Gln Phe Phe Pro Thr Leu Leu Leu Trp Ser Phe Ser Ala Leu Leu Pro 
465                 470                 475                 480 


Ser Ile Val Tyr Tyr Ser Thr Leu Leu Glu Ser His Trp Thr Lys Ser 
                485                 490                 495     


Gly Glu Asn Gln Ile Met Met Thr Lys Val Tyr Ile Phe Leu Ile Phe 
            500                 505                 510         


Met Val Leu Ile Leu Pro Ser Leu Gly Leu Thr Ser Leu Asp Phe Phe 
        515                 520                 525             


Phe Arg Trp Leu Phe Asp Lys Thr Ser Ser Glu Ala Ser Ile Arg Leu 
    530                 535                 540                 


Glu Cys Val Phe Leu Pro Asp Gln Gly Ala Phe Phe Val Asn Tyr Val 
545                 550                 555                 560 


Ile Ala Ser Ala Phe Ile Gly Asn Gly Met Glu Leu Leu Arg Leu Pro 
                565                 570                 575     


Gly Leu Ile Leu Tyr Thr Phe Arg Met Ile Met Ala Lys Thr Ala Ala 
            580                 585                 590         


Asp Arg Arg Asn Val Lys Gln Asn Gln Ala Phe Gln Tyr Glu Phe Gly 
        595                 600                 605             


Ala Met Tyr Ala Trp Met Leu Cys Val Phe Thr Val Ile Val Ala Tyr 
    610                 615                 620                 


Ser Ile Thr Cys Pro Ile Ile Ala Pro Phe Gly Leu Ile Tyr Ile Leu 
625                 630                 635                 640 


Leu Lys His Met Val Asp Arg His Asn Leu Tyr Phe Val Tyr Leu Pro 
                645                 650                 655     


Ala Lys Leu Glu Lys Gly Ile His Phe Ala Ala Val Asn Gln Ala Leu 
            660                 665                 670         


Ala Ala Pro Ile Leu Cys Leu Phe Trp Leu Tyr Phe Phe Ser Phe Leu 
        675                 680                 685             


Arg Leu Gly Met Lys Ala Pro Ala Thr Leu Phe Thr Phe Leu Val Leu 
    690                 695                 700                 


Leu Leu Thr Ile Leu Val Cys Leu Ala His Thr Cys Phe Gly Cys Phe 
705                 710                 715                 720 


Lys His Leu Ser Pro Leu Asn Tyr Lys Thr Glu Glu Pro Ala Ser Asp 
                725                 730                 735     


Lys Gly Ser Glu Ala Glu Ala His Met Pro Pro Pro Phe Thr Pro Tyr 
            740                 745                 750         


Val Pro Arg Ile Leu Asn Gly Leu Ala Ser Glu Arg Thr Ala Leu Ser 
        755                 760                 765             


Pro Gln Gln Gln Gln Gln Gln Thr Tyr Gly Ala Ile His Asn Ile Ser 
    770                 775                 780                 


Gly Thr Ile Pro Gly Gln Cys Leu Ala Gln Ser Ala Thr Gly Ser Val 
785                 790                 795                 800 


Ala Ala Ala Pro Gln Glu Ala 
                805         


<210>  3976
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  3976

Met Val Ser Met Ser Phe Lys Arg Asn Arg Ser Asp Arg Phe Tyr Ser 
1               5                   10                  15      


Thr Arg Cys Cys Gly Cys Cys His Val Arg Thr Gly Thr Ile Ile Leu 
            20                  25                  30          


Gly Thr Trp Tyr Met Val Val Asn Leu Leu Met Ala Ile Leu Leu Thr 
        35                  40                  45              


Val Glu Val Thr His Pro Asn Ser Met Pro Ala Val Asn Ile Gln Tyr 
    50                  55                  60                  


Glu Val Ile Gly Asn Tyr Tyr Ser Ser Glu Arg Met Ala Asp Asn Ala 
65                  70                  75                  80  


Cys Val Leu Phe Ala Val Ser Val Leu Met Phe Ile Ile Ser Ser Met 
                85                  90                  95      


Leu Val Tyr Gly Ala Ile Ser Tyr Gln Val Gly Trp Leu Ile Pro Phe 
            100                 105                 110         


Phe Cys Tyr Arg Leu Phe Asp Phe Val Leu Ser Cys Leu Val Ala Ile 
        115                 120                 125             


Ser Ser Leu Thr Tyr Leu Pro Arg Ile Lys Glu Tyr Leu Asp Gln Leu 
    130                 135                 140                 


Pro Asp Phe Pro Tyr Lys Asp Asp Leu Leu Ala Leu Asp Ser Ser Cys 
145                 150                 155                 160 


Leu Leu Phe Ile Val Leu Val Phe Phe Ala Leu Phe Ile Ile Phe Lys 
                165                 170                 175     


Ala Tyr Leu Ile Asn Cys Val Trp Asn Cys Tyr Lys Tyr Ile Asn Asn 
            180                 185                 190         


Arg Asn Val Pro Glu Ile Ala Val Tyr Pro Ala Phe Glu Ala Pro Pro 
        195                 200                 205             


Gln Tyr Val Leu Pro Thr Tyr Glu Met Ala Val Lys Met Pro Glu Lys 
    210                 215                 220                 


Glu Pro Pro Pro Pro Tyr Leu Pro Ala 
225                 230             


<210>  3977
<211>  956
<212>  PRT
<213>  Homo sapiens

<400>  3977

Met Thr Leu Leu Leu Leu Pro Leu Leu Leu Ala Ser Leu Leu Ala Ser 
1               5                   10                  15      


Cys Ser Cys Asn Lys Ala Asn Lys His Lys Pro Trp Ile Glu Ala Glu 
            20                  25                  30          


Tyr Gln Gly Ile Val Met Glu Asn Asp Asn Thr Val Leu Leu Asn Pro 
        35                  40                  45              


Pro Leu Phe Ala Leu Asp Lys Asp Ala Pro Leu Arg Tyr Ala Gly Glu 
    50                  55                  60                  


Ile Cys Gly Phe Arg Leu His Gly Ser Gly Val Pro Phe Glu Ala Val 
65                  70                  75                  80  


Ile Leu Asp Lys Ala Thr Gly Glu Gly Leu Ile Arg Ala Lys Glu Pro 
                85                  90                  95      


Val Asp Cys Glu Ala Gln Lys Glu His Thr Phe Thr Ile Gln Ala Tyr 
            100                 105                 110         


Asp Cys Gly Glu Gly Pro Asp Gly Ala Asn Thr Lys Lys Ser His Lys 
        115                 120                 125             


Ala Thr Val His Val Arg Val Asn Asp Val Asn Glu Phe Ala Pro Val 
    130                 135                 140                 


Phe Val Glu Arg Leu Tyr Arg Ala Ala Val Thr Glu Gly Lys Leu Tyr 
145                 150                 155                 160 


Asp Arg Ile Leu Arg Val Glu Ala Ile Asp Gly Asp Cys Ser Pro Gln 
                165                 170                 175     


Tyr Ser Gln Ile Cys Tyr Tyr Glu Ile Leu Thr Pro Asn Thr Pro Phe 
            180                 185                 190         


Leu Ile Asp Asn Asp Gly Asn Ile Glu Asn Thr Glu Lys Leu Gln Tyr 
        195                 200                 205             


Ser Gly Glu Arg Leu Tyr Lys Phe Thr Val Thr Ala Tyr Asp Cys Gly 
    210                 215                 220                 


Lys Lys Arg Ala Ala Asp Asp Ala Glu Val Glu Ile Gln Val Lys Pro 
225                 230                 235                 240 


Thr Cys Lys Pro Ser Trp Gln Gly Trp Asn Lys Arg Ile Glu Tyr Ala 
                245                 250                 255     


Pro Gly Ala Gly Ser Leu Ala Leu Phe Pro Gly Ile Arg Leu Glu Thr 
            260                 265                 270         


Cys Asp Glu Pro Leu Trp Asn Ile Gln Ala Thr Ile Glu Leu Gln Thr 
        275                 280                 285             


Ser His Val Ala Lys Gly Cys Asp Arg Asp Asn Tyr Ser Glu Arg Ala 
    290                 295                 300                 


Leu Arg Lys Leu Cys Gly Ala Ala Thr Gly Glu Val Asp Leu Leu Pro 
305                 310                 315                 320 


Met Pro Gly Pro Asn Ala Asn Trp Thr Ala Gly Leu Ser Val His Tyr 
                325                 330                 335     


Ser Gln Asp Ser Ser Leu Ile Tyr Trp Phe Asn Gly Thr Gln Ala Val 
            340                 345                 350         


Gln Val Pro Leu Gly Gly Pro Ser Gly Leu Gly Ser Gly Pro Gln Asp 
        355                 360                 365             


Ser Leu Ser Asp His Phe Thr Leu Ser Phe Trp Met Lys His Gly Val 
    370                 375                 380                 


Thr Pro Asn Lys Gly Lys Lys Glu Glu Glu Thr Ile Val Cys Asn Thr 
385                 390                 395                 400 


Val Gln Asn Glu Asp Gly Phe Ser His Tyr Ser Leu Thr Val His Gly 
                405                 410                 415     


Cys Arg Ile Ala Phe Leu Tyr Trp Pro Leu Leu Glu Ser Ala Arg Pro 
            420                 425                 430         


Val Lys Phe Leu Trp Lys Leu Glu Gln Val Cys Asp Asp Glu Trp His 
        435                 440                 445             


His Tyr Ala Leu Asn Leu Glu Phe Pro Thr Val Thr Leu Tyr Thr Asp 
    450                 455                 460                 


Gly Ile Ser Phe Asp Pro Ala Leu Ile His Asp Asn Gly Leu Ile His 
465                 470                 475                 480 


Pro Pro Arg Arg Glu Pro Ala Leu Met Ile Gly Ala Cys Trp Thr Glu 
                485                 490                 495     


Glu Lys Asn Lys Glu Lys Glu Lys Gly Asp Asn Ser Thr Asp Thr Thr 
            500                 505                 510         


Gln Gly Asp Pro Leu Ser Ile His His Tyr Phe His Gly Tyr Leu Ala 
        515                 520                 525             


Gly Phe Ser Val Arg Ser Gly Arg Leu Glu Ser Arg Glu Val Ile Glu 
    530                 535                 540                 


Cys Leu Tyr Ala Cys Arg Glu Gly Leu Asp Tyr Arg Asp Phe Glu Ser 
545                 550                 555                 560 


Leu Gly Lys Gly Met Lys Val His Val Asn Pro Ser Gln Ser Leu Leu 
                565                 570                 575     


Thr Leu Glu Gly Asp Asp Val Glu Thr Phe Asn His Ala Leu Gln His 
            580                 585                 590         


Val Ala Tyr Met Asn Thr Leu Arg Phe Ala Thr Pro Gly Val Arg Pro 
        595                 600                 605             


Leu Arg Leu Thr Thr Ala Val Lys Cys Phe Ser Glu Glu Ser Cys Val 
    610                 615                 620                 


Ser Ile Pro Glu Val Glu Gly Tyr Val Val Val Leu Gln Pro Asp Ala 
625                 630                 635                 640 


Pro Gln Ile Leu Leu Ser Gly Thr Ala His Phe Ala Arg Pro Ala Val 
                645                 650                 655     


Asp Phe Glu Gly Thr Asn Gly Val Pro Leu Phe Pro Asp Leu Gln Ile 
            660                 665                 670         


Thr Cys Ser Ile Ser His Gln Val Glu Ala Lys Lys Asp Glu Ser Trp 
        675                 680                 685             


Gln Gly Thr Val Thr Asp Thr Arg Met Ser Asp Glu Ile Val His Asn 
    690                 695                 700                 


Leu Asp Gly Cys Glu Ile Ser Leu Val Gly Asp Asp Leu Asp Pro Glu 
705                 710                 715                 720 


Arg Glu Ser Leu Leu Leu Asp Thr Thr Ser Leu Gln Gln Arg Gly Leu 
                725                 730                 735     


Glu Leu Thr Asn Thr Ser Ala Tyr Leu Thr Ile Ala Gly Val Glu Ser 
            740                 745                 750         


Ile Thr Val Tyr Glu Glu Ile Leu Arg Gln Ala Arg Tyr Arg Leu Arg 
        755                 760                 765             


His Gly Ala Ala Leu Tyr Thr Arg Lys Phe Arg Leu Ser Cys Ser Glu 
    770                 775                 780                 


Met Asn Gly Arg Tyr Ser Ser Asn Glu Phe Ile Val Glu Val Asn Val 
785                 790                 795                 800 


Leu His Ser Met Asn Arg Val Ala His Pro Ser His Val Leu Ser Ser 
                805                 810                 815     


Gln Gln Phe Leu His Arg Gly His Gln Pro Pro Pro Glu Met Ala Gly 
            820                 825                 830         


His Ser Leu Ala Ser Ser His Arg Asn Ser Met Ile Pro Ser Ala Ala 
        835                 840                 845             


Thr Leu Ile Ile Val Val Cys Val Gly Phe Leu Val Leu Met Val Val 
    850                 855                 860                 


Leu Gly Leu Val Arg Ile His Ser Leu His Arg Arg Val Ser Gly Ala 
865                 870                 875                 880 


Gly Gly Pro Pro Gly Ala Ser Ser Asp Pro Lys Asp Pro Asp Leu Phe 
                885                 890                 895     


Trp Asp Asp Ser Ala Leu Thr Ile Ile Val Asn Pro Met Glu Ser Tyr 
            900                 905                 910         


Gln Asn Arg Gln Ser Cys Val Thr Gly Ala Val Gly Gly Gln Gln Glu 
        915                 920                 925             


Asp Glu Asp Ser Ser Asp Ser Glu Val Ala Asp Ser Pro Ser Ser Asp 
    930                 935                 940                 


Glu Arg Arg Ile Ile Glu Thr Pro Pro His Arg Tyr 
945                 950                 955     


<210>  3978
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  3978

Met Leu Gly Ala Trp Ala Val Glu Gly Thr Ala Val Ala Leu Leu Arg 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Pro Pro Ala Ile Arg Gly Pro Gly Leu Gly 
            20                  25                  30          


Val Ala Gly Val Ala Gly Ala Ala Gly Ala Gly Leu Pro Glu Ser Val 
        35                  40                  45              


Ile Trp Ala Val Asn Ala Gly Gly Glu Ala His Val Asp Val His Gly 
    50                  55                  60                  


Ile His Phe Arg Lys Asp Pro Leu Glu Gly Arg Val Gly Arg Ala Ser 
65                  70                  75                  80  


Asp Tyr Gly Met Lys Leu Pro Ile Leu Arg Ser Asn Pro Glu Asp Gln 
                85                  90                  95      


Ile Leu Tyr Gln Thr Glu Arg Tyr Asn Glu Glu Thr Phe Gly Tyr Glu 
            100                 105                 110         


Val Pro Ile Lys Glu Glu Gly Asp Tyr Val Leu Val Leu Lys Phe Ala 
        115                 120                 125             


Glu Val Tyr Phe Ala Gln Ser Gln Gln Lys Val Phe Asp Val Arg Leu 
    130                 135                 140                 


Asn Gly His Val Val Val Lys Asp Leu Asp Ile Phe Asp Arg Val Gly 
145                 150                 155                 160 


His Ser Thr Ala His Asp Glu Ile Ile Pro Met Ser Ile Arg Lys Gly 
                165                 170                 175     


Lys Leu Ser Val Gln Gly Glu Val Ser Thr Phe Thr Gly Lys Leu Tyr 
            180                 185                 190         


Ile Glu Phe Val Lys Gly Tyr Tyr Asp Asn Pro Lys Val Cys Ala Leu 
        195                 200                 205             


Tyr Ile Met Ala Gly Thr Val Asp Asp Val Pro Lys Leu Gln Pro His 
    210                 215                 220                 


Pro Gly Leu Glu Lys Lys Glu Glu Glu Glu Glu Glu Glu Glu Tyr Asp 
225                 230                 235                 240 


Glu Gly Ser Asn Leu Lys Lys Gln Thr Asn Lys Asn Arg Val Gln Ser 
                245                 250                 255     


Gly Pro Arg Thr Pro Asn Pro Tyr Ala Ser Asp Asn Ser Ser Leu Met 
            260                 265                 270         


Phe Pro Ile Leu Val Ala Phe Gly Val Phe Ile Pro Thr Leu Phe Cys 
        275                 280                 285             


Leu Cys Arg Leu 
    290         


<210>  3979
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  3979

Met Cys His Gly Arg Ile Ala Pro Lys Ser Thr Ser Val Phe Ala Val 
1               5                   10                  15      


Ala Ser Val Gly His Gly Val Phe Leu Pro Leu Val Ile Leu Cys Thr 
            20                  25                  30          


Leu Leu Gly Asp Gly Leu Ala Ser Val Cys Pro Leu Pro Pro Glu Pro 
        35                  40                  45              


Glu Asn Gly Gly Tyr Ile Cys His Pro Arg Pro Cys Arg Asp Pro Leu 
    50                  55                  60                  


Thr Ala Gly Ser Val Ile Glu Tyr Leu Cys Ala Glu Gly Tyr Met Leu 
65                  70                  75                  80  


Lys Gly Asp Tyr Lys Tyr Leu Thr Cys Lys Asn Gly Glu Trp Lys Pro 
                85                  90                  95      


Ala Met Glu Ile Ser Cys Arg Leu Asn Glu Asp Lys Asp Thr His Thr 
            100                 105                 110         


Ser Leu Gly Val Pro Thr Leu Ser Ile Val Ala Ser Thr Ala Ser Ser 
        115                 120                 125             


Val Ala Leu Ile Leu Leu Leu Val Val Leu Phe Val Leu Leu Gln Pro 
    130                 135                 140                 


Lys Leu Lys Ser Phe His His Ser Arg Arg Asp Gln Gly Val Ser Gly 
145                 150                 155                 160 


Asp Gln Val Ser Ile Met Val Asp Gly Val Gln Val Ala Leu Pro Ser 
                165                 170                 175     


Tyr Glu Glu Ala Val Tyr Gly Ser Ser Gly His Cys Val Pro Pro Ala 
            180                 185                 190         


Asp Pro Arg Val Gln Ile Val Leu Ser Glu Gly Ser Gly Pro Ser Gly 
        195                 200                 205             


Arg Ser Val Pro Arg Glu Gln Gln Leu Pro Asp Gln Gly Ala Cys Ser 
    210                 215                 220                 


Ser Ala Gly Gly Glu Asp Glu Ala Pro Gly Gln Ser Gly Leu Cys Glu 
225                 230                 235                 240 


Ala Trp Gly Ser Arg Ala Ser Glu Thr Val Met Val His Gln Ala Thr 
                245                 250                 255     


Thr Ser Ser Trp Val Ala Gly Ser Gly Asn Arg Gln Leu Ala His Lys 
            260                 265                 270         


Glu Thr Ala Asp Ser Glu Asn Ser Asp Ile Gln Ser Leu Leu Ser Leu 
        275                 280                 285             


Thr Ser Glu Glu Tyr Thr Asp Asp Ile Pro Leu Leu Lys Glu Ala 
    290                 295                 300             


<210>  3980
<211>  642
<212>  PRT
<213>  Homo sapiens

<400>  3980

Met Ala Thr Ala Met Asp Trp Leu Pro Trp Ser Leu Leu Leu Phe Ser 
1               5                   10                  15      


Leu Met Cys Glu Thr Ser Ala Phe Tyr Val Pro Gly Val Ala Pro Ile 
            20                  25                  30          


Asn Phe His Gln Asn Asp Pro Val Glu Ile Lys Ala Val Lys Leu Thr 
        35                  40                  45              


Ser Ser Arg Thr Gln Leu Pro Tyr Glu Tyr Tyr Ser Leu Pro Phe Cys 
    50                  55                  60                  


Gln Pro Ser Lys Ile Thr Tyr Lys Ala Glu Asn Leu Gly Glu Val Leu 
65                  70                  75                  80  


Arg Gly Asp Arg Ile Val Asn Thr Pro Phe Gln Val Leu Met Asn Ser 
                85                  90                  95      


Glu Lys Lys Cys Glu Val Leu Cys Ser Gln Ser Asn Lys Pro Val Thr 
            100                 105                 110         


Leu Thr Val Glu Gln Ser Arg Leu Val Ala Glu Arg Ile Thr Glu Asp 
        115                 120                 125             


Tyr Tyr Val His Leu Ile Ala Asp Asn Leu Pro Val Ala Thr Arg Leu 
    130                 135                 140                 


Glu Leu Tyr Ser Asn Arg Asp Ser Asp Asp Lys Lys Lys Glu Lys Asp 
145                 150                 155                 160 


Val Gln Phe Glu His Gly Tyr Arg Leu Gly Phe Thr Asp Val Asn Lys 
                165                 170                 175     


Ile Tyr Leu His Asn His Leu Ser Phe Ile Leu Tyr Tyr His Arg Glu 
            180                 185                 190         


Asp Met Glu Glu Asp Gln Glu His Thr Tyr Arg Val Val Arg Phe Glu 
        195                 200                 205             


Val Ile Pro Gln Ser Ile Arg Leu Glu Asp Leu Lys Ala Asp Glu Lys 
    210                 215                 220                 


Ser Ser Cys Thr Leu Pro Glu Gly Thr Asn Ser Ser Pro Gln Glu Ile 
225                 230                 235                 240 


Asp Pro Thr Lys Glu Asn Gln Leu Tyr Phe Thr Tyr Ser Val His Trp 
                245                 250                 255     


Glu Glu Ser Asp Ile Lys Trp Ala Ser Arg Trp Asp Thr Tyr Leu Thr 
            260                 265                 270         


Met Ser Asp Val Gln Ile His Trp Phe Ser Ile Ile Asn Ser Val Val 
        275                 280                 285             


Val Val Phe Phe Leu Ser Gly Ile Leu Ser Met Ile Ile Ile Arg Thr 
    290                 295                 300                 


Leu Arg Lys Asp Ile Ala Asn Tyr Asn Lys Glu Asp Asp Ile Glu Asp 
305                 310                 315                 320 


Thr Met Glu Glu Ser Gly Trp Lys Leu Val His Gly Asp Val Phe Arg 
                325                 330                 335     


Pro Pro Gln Tyr Pro Met Ile Leu Ser Ser Leu Leu Gly Ser Gly Ile 
            340                 345                 350         


Gln Leu Phe Cys Met Ile Leu Ile Val Ile Phe Val Ala Met Leu Gly 
        355                 360                 365             


Met Leu Ser Pro Ser Ser Arg Gly Ala Leu Met Thr Thr Ala Cys Phe 
    370                 375                 380                 


Leu Phe Met Phe Met Gly Val Phe Gly Gly Phe Ser Ala Gly Arg Leu 
385                 390                 395                 400 


Tyr Arg Thr Leu Lys Gly His Arg Trp Lys Lys Gly Ala Phe Cys Thr 
                405                 410                 415     


Ala Thr Leu Tyr Pro Gly Val Val Phe Gly Ile Cys Phe Val Leu Asn 
            420                 425                 430         


Cys Phe Ile Trp Gly Lys His Ser Ser Gly Ala Val Pro Phe Pro Thr 
        435                 440                 445             


Met Val Ala Leu Leu Cys Met Trp Phe Gly Ile Ser Leu Pro Leu Val 
    450                 455                 460                 


Tyr Leu Gly Tyr Tyr Phe Gly Phe Arg Lys Gln Pro Tyr Asp Asn Pro 
465                 470                 475                 480 


Val Arg Thr Asn Gln Ile Pro Arg Gln Ile Pro Glu Gln Arg Trp Tyr 
                485                 490                 495     


Met Asn Arg Phe Val Gly Ile Leu Met Ala Gly Ile Leu Pro Phe Gly 
            500                 505                 510         


Ala Met Phe Ile Glu Leu Phe Phe Ile Phe Ser Ala Ile Trp Glu Asn 
        515                 520                 525             


Gln Phe Tyr Tyr Leu Phe Gly Phe Leu Phe Leu Val Phe Ile Ile Leu 
    530                 535                 540                 


Val Val Ser Cys Ser Gln Ile Ser Ile Val Met Val Tyr Phe Gln Leu 
545                 550                 555                 560 


Cys Ala Glu Asp Tyr Arg Trp Trp Trp Arg Asn Phe Leu Val Ser Gly 
                565                 570                 575     


Gly Ser Ala Phe Tyr Val Leu Val Tyr Ala Ile Phe Tyr Phe Val Asn 
            580                 585                 590         


Lys Leu Asp Ile Val Glu Phe Ile Pro Ser Leu Leu Tyr Phe Gly Tyr 
        595                 600                 605             


Thr Ala Leu Met Val Leu Ser Phe Trp Leu Leu Thr Gly Thr Ile Gly 
    610                 615                 620                 


Phe Tyr Ala Ala Tyr Met Phe Val Arg Lys Ile Tyr Ala Ala Val Lys 
625                 630                 635                 640 


Ile Asp 
        


<210>  3981
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  3981

Met Thr Thr Thr Arg Tyr Arg Pro Thr Trp Asp Leu Ala Leu Asp Pro 
1               5                   10                  15      


Leu Val Ser Cys Lys Leu Cys Leu Gly Glu Tyr Pro Val Glu Gln Met 
            20                  25                  30          


Thr Thr Ile Ala Gln Cys Gln Cys Ile Phe Cys Thr Leu Cys Leu Lys 
        35                  40                  45              


Gln Tyr Val Glu Leu Leu Ile Lys Glu Gly Leu Glu Thr Ala Ile Ser 
    50                  55                  60                  


Cys Pro Asp Ala Ala Cys Pro Lys Gln Gly His Leu Gln Glu Asn Glu 
65                  70                  75                  80  


Ile Glu Cys Met Val Ala Ala Glu Ile Met Gln Arg Tyr Lys Lys Leu 
                85                  90                  95      


Gln Phe Glu Arg Glu Val Leu Phe Asp Pro Cys Arg Thr Trp Cys Pro 
            100                 105                 110         


Ala Ser Thr Cys Gln Ala Val Cys Gln Leu Gln Asp Val Gly Leu Gln 
        115                 120                 125             


Thr Pro Gln Pro Val Gln Cys Lys Ala Cys Arg Met Glu Phe Cys Ser 
    130                 135                 140                 


Thr Cys Lys Ala Ser Trp His Pro Gly Gln Gly Cys Pro Glu Thr Met 
145                 150                 155                 160 


Pro Ile Thr Phe Leu Pro Gly Glu Thr Ser Ala Ala Phe Lys Met Glu 
                165                 170                 175     


Glu Asp Asp Ala Pro Ile Lys Arg Cys Pro Lys Cys Lys Val Tyr Ile 
            180                 185                 190         


Glu Arg Asp Glu Gly Cys Ala Gln Met Met Cys Lys Asn Cys Lys His 
        195                 200                 205             


Ala Phe Cys Trp Tyr Cys Leu Glu Ser Leu Asp Asp Asp Phe Leu Leu 
    210                 215                 220                 


Ile His Tyr Asp Lys Gly Pro Cys Arg Asn Lys Leu Gly His Ser Arg 
225                 230                 235                 240 


Ala Ser Val Ile Trp His Arg Thr Gln Val Val Gly Ile Phe Ala Gly 
                245                 250                 255     


Phe Gly Leu Leu Leu Leu Val Ala Ser Pro Phe Leu Leu Leu Ala Thr 
            260                 265                 270         


Pro Phe Val Leu Cys Cys Lys Cys Lys Cys Ser Lys Gly Asp Asp Asp 
        275                 280                 285             


Pro Leu Pro Thr 
    290         


<210>  3982
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  3982

Met Ala Ala Ala Ala Val Gln Gly Gly Arg Ser Gly Gly Ser Gly Gly 
1               5                   10                  15      


Cys Ser Gly Ala Gly Gly Ala Ser Asn Cys Gly Thr Gly Ser Gly Arg 
            20                  25                  30          


Ser Gly Leu Leu Asp Lys Trp Lys Ile Asp Asp Lys Pro Val Lys Ile 
        35                  40                  45              


Asp Lys Trp Asp Gly Ser Ala Val Lys Asn Ser Leu Asp Asp Ser Ala 
    50                  55                  60                  


Lys Lys Val Leu Leu Glu Lys Tyr Lys Tyr Val Glu Asn Phe Gly Leu 
65                  70                  75                  80  


Ile Asp Gly Arg Leu Thr Ile Cys Thr Ile Ser Cys Phe Phe Ala Ile 
                85                  90                  95      


Val Ala Leu Ile Trp Asp Tyr Met His Pro Phe Pro Glu Ser Lys Pro 
            100                 105                 110         


Val Leu Ala Leu Cys Val Ile Ser Tyr Phe Val Met Met Gly Ile Leu 
        115                 120                 125             


Thr Ile Tyr Thr Ser Tyr Lys Glu Lys Ser Ile Phe Leu Val Ala His 
    130                 135                 140                 


Arg Lys Asp Pro Thr Gly Met Asp Pro Asp Asp Ile Trp Gln Leu Ser 
145                 150                 155                 160 


Ser Ser Leu Lys Arg Phe Asp Asp Lys Tyr Thr Leu Lys Leu Thr Phe 
                165                 170                 175     


Ile Ser Gly Arg Thr Lys Gln Gln Arg Glu Ala Glu Phe Thr Lys Ser 
            180                 185                 190         


Ile Ala Lys Phe Phe Asp His Ser Gly Thr Leu Val Met Asp Ala Tyr 
        195                 200                 205             


Glu Pro Glu Ile Ser Arg Leu His Asp Ser Leu Ala Ile Glu Arg Lys 
    210                 215                 220                 


Ile Lys 
225     


<210>  3983
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  3983

Met Ala Ser Cys Val Gly Ser Arg Thr Leu Ser Lys Asp Asp Val Asn 
1               5                   10                  15      


Tyr Lys Met His Phe Arg Met Ile Asn Glu Gln Gln Val Glu Asp Ile 
            20                  25                  30          


Thr Ile Asp Phe Phe Tyr Arg Pro His Thr Ile Thr Leu Leu Ser Phe 
        35                  40                  45              


Thr Ile Val Ser Leu Met Tyr Phe Ala Phe Thr Arg Asp Asp Ser Val 
    50                  55                  60                  


Pro Glu Asp Asn Ile Trp Arg Gly Ile Leu Ser Val Ile Phe Phe Phe 
65                  70                  75                  80  


Leu Ile Ile Ser Val Leu Ala Phe Pro Asn Gly Pro Phe Thr Arg Pro 
                85                  90                  95      


His Pro Ala Leu Trp Arg Met Val Phe Gly Leu Ser Val Leu Tyr Phe 
            100                 105                 110         


Leu Phe Leu Val Phe Leu Leu Phe Leu Asn Phe Glu Gln Val Lys Ser 
        115                 120                 125             


Leu Met Tyr Trp Leu Asp Pro Asn Leu Arg Tyr Ala Thr Arg Glu Ala 
    130                 135                 140                 


Asp Val Met Glu Tyr Ala Val Asn Cys His Val Ile Thr Trp Glu Arg 
145                 150                 155                 160 


Ile Ile Ser His Phe Asp Ile Phe Ala Phe Gly His Phe Trp Gly Trp 
                165                 170                 175     


Ala Met Lys Ala Leu Leu Ile Arg Ser Tyr Gly Leu Cys Trp Thr Ile 
            180                 185                 190         


Ser Ile Thr Trp Glu Leu Thr Glu Leu Phe Phe Met His Leu Leu Pro 
        195                 200                 205             


Asn Phe Ala Glu Cys Trp Trp Asp Gln Val Ile Leu Asp Ile Leu Leu 
    210                 215                 220                 


Cys Asn Gly Gly Gly Ile Trp Leu Gly Met Val Val Cys Arg Phe Leu 
225                 230                 235                 240 


Glu Met Arg Thr Tyr His Trp Ala Ser Phe Lys Asp Ile His Thr Thr 
                245                 250                 255     


Thr Gly Lys Ile Lys Arg Ala Val Leu Gln Phe Thr Pro Ala Ser Trp 
            260                 265                 270         


Thr Tyr Val Arg Trp Phe Asp Pro Lys Ser Ser Phe Gln Arg Val Ala 
        275                 280                 285             


Gly Val Tyr Leu Phe Met Ile Ile Trp Gln Leu Thr Glu Leu Asn Thr 
    290                 295                 300                 


Phe Phe Leu Lys His Ile Phe Val Phe Gln Ala Ser His Pro Leu Ser 
305                 310                 315                 320 


Trp Gly Arg Ile Leu Phe Ile Gly Gly Ile Thr Ala Pro Thr Val Arg 
                325                 330                 335     


Gln Tyr Tyr Ala Tyr Leu Thr Asp Thr Gln Cys Lys Arg Val Gly Thr 
            340                 345                 350         


Gln Cys Trp Val Phe Gly Val Ile Gly Phe Leu Glu Ala Ile Val Cys 
        355                 360                 365             


Ile Lys Phe Gly Gln Asp Leu Phe Ser Lys Thr Gln Ile Leu Tyr Val 
    370                 375                 380                 


Val Leu Trp Leu Leu Cys Val Ala Phe Thr Thr Phe Leu Cys Leu Tyr 
385                 390                 395                 400 


Gly Met Ile Trp Tyr Ala Glu His Tyr Gly His Arg Glu Lys Thr Tyr 
                405                 410                 415     


Ser Glu Cys Glu Asp Gly Thr Tyr Ser Pro Glu Ile Ser Trp His His 
            420                 425                 430         


Arg Lys Gly Thr Lys Gly Ser Glu Asp Ser Pro Pro Lys His Ala Gly 
        435                 440                 445             


Asn Asn Glu Ser His Ser Ser Arg Arg Arg Asn Arg His Ser Lys Ser 
    450                 455                 460                 


Lys Val Thr Asn Gly Val Gly Lys Lys 
465                 470             


<210>  3984
<211>  992
<212>  PRT
<213>  Homo sapiens

<400>  3984

Met Lys Thr Glu Thr Val Pro Pro Phe Gln Glu Thr Pro Ala Gly Ser 
1               5                   10                  15      


Ser Cys His Leu Asn Asn Leu Leu Ser Ser Arg Lys Leu Met Ala Val 
            20                  25                  30          


Gly Val Leu Leu Gly Trp Leu Leu Val Ile His Leu Leu Val Asn Val 
        35                  40                  45              


Trp Leu Leu Cys Leu Leu Ser Ala Leu Leu Val Val Leu Gly Gly Trp 
    50                  55                  60                  


Leu Gly Ser Ser Leu Ala Gly Val Ala Ser Gly Arg Leu His Leu Glu 
65                  70                  75                  80  


Arg Phe Ile Pro Leu Ala Thr Cys Pro Pro Cys Pro Glu Ala Glu Arg 
                85                  90                  95      


Gln Leu Glu Arg Glu Ile Asn Arg Thr Ile Gln Met Ile Ile Arg Asp 
            100                 105                 110         


Phe Val Leu Ser Trp Tyr Arg Ser Val Ser Gln Glu Pro Ala Phe Glu 
        115                 120                 125             


Glu Glu Met Glu Ala Ala Met Lys Gly Leu Val Gln Glu Leu Arg Arg 
    130                 135                 140                 


Arg Met Ser Val Met Asp Ser His Ala Val Ala Gln Ser Val Leu Thr 
145                 150                 155                 160 


Leu Cys Gly Cys His Leu Gln Ser Tyr Ile Gln Ala Lys Glu Ala Thr 
                165                 170                 175     


Ala Gly Lys Asn Gly Pro Val Glu Pro Ser His Leu Trp Glu Ala Tyr 
            180                 185                 190         


Cys Arg Ala Thr Ala Pro His Pro Ala Val His Ser Pro Ser Ala Glu 
        195                 200                 205             


Val Thr Tyr Thr Arg Gly Val Val Asn Leu Leu Leu Gln Gly Leu Val 
    210                 215                 220                 


Pro Lys Pro His Leu Glu Thr Arg Thr Gly Arg His Val Val Val Glu 
225                 230                 235                 240 


Leu Ile Thr Cys Asn Val Ile Leu Pro Leu Ile Ser Arg Leu Ser Asp 
                245                 250                 255     


Pro Asp Trp Ile His Leu Val Leu Val Gly Ile Phe Ser Lys Ala Arg 
            260                 265                 270         


Asp Pro Ala Pro Cys Pro Ala Ser Ala Pro Glu Gln Pro Ser Val Pro 
        275                 280                 285             


Thr Ser Leu Pro Leu Ile Ala Glu Val Glu Gln Leu Pro Glu Gly Arg 
    290                 295                 300                 


Ala Ser Pro Val Ala Ala Pro Val Phe Leu Ser Tyr Ser Glu Pro Glu 
305                 310                 315                 320 


Gly Ser Ala Gly Pro Ser Pro Glu Val Glu Glu Gly His Glu Ala Val 
                325                 330                 335     


Glu Gly Asp Leu Gly Gly Met Cys Glu Glu Arg Lys Val Gly Asn Asn 
            340                 345                 350         


Ser Ser His Phe Leu Gln Pro Asn Val Arg Gly Pro Leu Phe Leu Cys 
        355                 360                 365             


Glu Asp Ser Glu Leu Glu Ser Pro Leu Ser Glu Leu Gly Lys Glu Thr 
    370                 375                 380                 


Ile Met Leu Met Thr Pro Gly Ser Phe Leu Ser Asp Arg Ile Gln Asp 
385                 390                 395                 400 


Ala Leu Cys Ala Leu Glu Ser Ser Gln Ala Leu Glu Pro Lys Asp Gly 
                405                 410                 415     


Glu Ala Ser Glu Gly Ala Glu Ala Glu Glu Gly Pro Gly Thr Glu Thr 
            420                 425                 430         


Glu Thr Gly Leu Pro Val Ser Thr Leu Asn Ser Cys Pro Glu Ile His 
        435                 440                 445             


Ile Asp Thr Ala Asp Lys Glu Ile Glu Gln Gly Asp Val Thr Ala Ser 
    450                 455                 460                 


Val Thr Ala Leu Leu Glu Gly Pro Glu Lys Thr Cys Pro Ser Arg Pro 
465                 470                 475                 480 


Ser Cys Leu Glu Lys Asp Leu Thr Asn Asp Val Ser Ser Leu Asp Pro 
                485                 490                 495     


Thr Leu Pro Pro Val Leu Leu Ser Ser Ser Pro Pro Gly Pro Leu Ser 
            500                 505                 510         


Ser Ala Thr Phe Ser Phe Glu Pro Leu Ser Ser Pro Asp Gly Pro Val 
        515                 520                 525             


Ile Ile Gln Asn Leu Arg Ile Thr Gly Thr Ile Thr Ala Arg Glu His 
    530                 535                 540                 


Ser Gly Thr Gly Phe His Pro Tyr Thr Leu Tyr Thr Val Lys Tyr Glu 
545                 550                 555                 560 


Thr Ala Leu Asp Gly Glu Asn Ser Ser Gly Leu Gln Gln Leu Ala Tyr 
                565                 570                 575     


His Thr Val Asn Arg Arg Tyr Arg Glu Phe Leu Asn Leu Gln Thr Arg 
            580                 585                 590         


Leu Glu Glu Lys Pro Asp Leu Arg Lys Phe Ile Lys Asn Val Lys Gly 
        595                 600                 605             


Pro Lys Lys Leu Phe Pro Asp Leu Pro Phe Gly Asn Met Asp Ser Asp 
    610                 615                 620                 


Arg Val Glu Ala Arg Lys Ser Leu Leu Glu Ser Phe Leu Lys Gln Leu 
625                 630                 635                 640 


Cys Ala Ile Pro Glu Ile Ala Asn Ser Glu Glu Val Gln Glu Phe Leu 
                645                 650                 655     


Ala Leu Asn Thr Asp Ala Arg Ile Ala Phe Val Lys Lys Pro Phe Met 
            660                 665                 670         


Val Ser Arg Ile Asp Lys Met Val Val Ser Ala Ile Val Asp Thr Leu 
        675                 680                 685             


Lys Thr Ala Phe Pro Arg Ser Glu Pro Gln Ser Pro Thr Glu Glu Leu 
    690                 695                 700                 


Ser Glu Ala Glu Thr Glu Ser Lys Pro Gln Thr Glu Gly Lys Lys Ala 
705                 710                 715                 720 


Ser Lys Ser Arg Leu Arg Phe Ser Ser Ser Lys Ile Ser Pro Ala Leu 
                725                 730                 735     


Ser Val Thr Glu Ala Gln Asp Lys Ile Leu Tyr Cys Leu Gln Glu Gly 
            740                 745                 750         


Asn Val Glu Ser Glu Thr Leu Ser Met Ser Ala Met Glu Ser Phe Ile 
        755                 760                 765             


Glu Lys Gln Thr Lys Leu Leu Glu Met Gln Pro Thr Lys Ala Pro Glu 
    770                 775                 780                 


Lys Asp Pro Glu Gln Pro Pro Lys Gly Arg Val Asp Ser Cys Val Ser 
785                 790                 795                 800 


Asp Ala Ala Val Pro Ala Gln Asp Pro Ser Asn Ser Asp Pro Gly Thr 
                805                 810                 815     


Glu Thr Glu Leu Ala Asp Thr Ala Leu Asp Leu Leu Leu Leu Leu Leu 
            820                 825                 830         


Thr Glu Gln Trp Lys Trp Leu Cys Thr Glu Asn Met Gln Lys Phe Leu 
        835                 840                 845             


Arg Leu Ile Phe Gly Thr Leu Val Gln Arg Trp Leu Glu Val Gln Val 
    850                 855                 860                 


Ala Asn Leu Thr Ser Pro Gln Arg Trp Val Gln Tyr Leu Leu Leu Leu 
865                 870                 875                 880 


Gln Glu Ser Ile Trp Pro Gly Gly Val Leu Pro Lys Phe Pro Arg Pro 
                885                 890                 895     


Val Arg Thr Gln Glu Gln Lys Leu Ala Ala Glu Lys Gln Ala Leu Gln 
            900                 905                 910         


Ser Leu Met Gly Val Leu Pro Asp Leu Val Val Glu Ile Leu Gly Val 
        915                 920                 925             


Asn Lys Cys Arg Leu Ser Trp Gly Leu Val Leu Glu Ser Leu Gln Gln 
    930                 935                 940                 


Pro Leu Ile Asn Arg His Leu Ile Tyr Cys Leu Gly Asp Ile Ile Leu 
945                 950                 955                 960 


Glu Phe Leu Asp Leu Ser Ala Ser Val Glu Glu Ser Ala Ala Thr Thr 
                965                 970                 975     


Ser Ala Ser Asp Thr Pro Gly Asn Ser Lys Arg Met Gly Val Ser Ser 
            980                 985                 990         


<210>  3985
<211>  516
<212>  PRT
<213>  Homo sapiens

<400>  3985

Met Glu Pro Ala Val Ser Leu Ala Val Cys Ala Leu Leu Phe Leu Leu 
1               5                   10                  15      


Trp Val Arg Leu Lys Gly Leu Glu Phe Val Leu Ile His Gln Arg Trp 
            20                  25                  30          


Val Phe Val Cys Leu Phe Leu Leu Pro Leu Ser Leu Ile Phe Asp Ile 
        35                  40                  45              


Tyr Tyr Tyr Val Arg Ala Trp Val Val Phe Lys Leu Ser Ser Ala Pro 
    50                  55                  60                  


Arg Leu His Glu Gln Arg Val Arg Asp Ile Gln Lys Gln Val Arg Glu 
65                  70                  75                  80  


Trp Lys Glu Gln Gly Ser Lys Thr Phe Met Cys Thr Gly Arg Pro Gly 
                85                  90                  95      


Trp Leu Thr Val Ser Leu Arg Val Gly Lys Tyr Lys Lys Thr His Lys 
            100                 105                 110         


Asn Ile Met Ile Asn Leu Met Asp Ile Leu Glu Val Asp Thr Lys Lys 
        115                 120                 125             


Gln Ile Val Arg Val Glu Pro Leu Val Thr Met Gly Gln Val Thr Ala 
    130                 135                 140                 


Leu Leu Thr Ser Ile Gly Trp Thr Leu Pro Val Leu Pro Glu Leu Asp 
145                 150                 155                 160 


Asp Leu Thr Val Gly Gly Leu Ile Met Gly Thr Gly Ile Glu Ser Ser 
                165                 170                 175     


Ser His Lys Tyr Gly Leu Phe Gln His Ile Cys Thr Ala Tyr Glu Leu 
            180                 185                 190         


Val Leu Ala Asp Gly Ser Phe Val Arg Cys Thr Pro Ser Glu Asn Ser 
        195                 200                 205             


Asp Leu Phe Tyr Ala Val Pro Trp Ser Cys Gly Thr Leu Gly Phe Leu 
    210                 215                 220                 


Val Ala Ala Glu Ile Arg Ile Ile Pro Ala Lys Lys Tyr Val Lys Leu 
225                 230                 235                 240 


Arg Phe Glu Pro Val Arg Gly Leu Glu Ala Ile Cys Ala Lys Phe Thr 
                245                 250                 255     


His Glu Ser Gln Arg Gln Glu Asn His Phe Val Glu Gly Leu Leu Tyr 
            260                 265                 270         


Ser Leu Asp Glu Ala Val Ile Met Thr Gly Val Met Thr Asp Glu Ala 
        275                 280                 285             


Glu Pro Ser Lys Leu Asn Ser Ile Gly Asn Tyr Tyr Lys Pro Trp Phe 
    290                 295                 300                 


Phe Lys His Val Glu Asn Tyr Leu Lys Thr Asn Arg Glu Gly Leu Glu 
305                 310                 315                 320 


Tyr Ile Pro Leu Arg His Tyr Tyr His Arg His Thr Arg Ser Ile Phe 
                325                 330                 335     


Trp Glu Leu Gln Asp Ile Ile Pro Phe Gly Asn Asn Pro Ile Phe Arg 
            340                 345                 350         


Tyr Leu Phe Gly Trp Met Val Pro Pro Lys Ile Ser Leu Leu Lys Leu 
        355                 360                 365             


Thr Gln Gly Glu Thr Leu Arg Lys Leu Tyr Glu Gln His His Val Val 
    370                 375                 380                 


Gln Asp Met Leu Val Pro Met Lys Cys Leu Gln Gln Ala Leu His Thr 
385                 390                 395                 400 


Phe Gln Asn Asp Ile His Val Tyr Pro Ile Trp Leu Cys Pro Phe Ile 
                405                 410                 415     


Leu Pro Ser Gln Pro Gly Leu Val His Pro Lys Gly Asn Glu Ala Glu 
            420                 425                 430         


Leu Tyr Ile Asp Ile Gly Ala Tyr Gly Glu Pro Arg Val Lys His Phe 
        435                 440                 445             


Glu Ala Arg Ser Cys Met Arg Gln Leu Glu Lys Phe Val Arg Ser Val 
    450                 455                 460                 


His Gly Phe Gln Met Leu Tyr Ala Asp Cys Tyr Met Asn Arg Glu Glu 
465                 470                 475                 480 


Phe Trp Glu Met Phe Asp Gly Ser Leu Tyr His Lys Leu Arg Glu Lys 
                485                 490                 495     


Leu Gly Cys Gln Asp Ala Phe Pro Glu Val Tyr Asp Lys Ile Cys Lys 
            500                 505                 510         


Ala Ala Arg His 
        515     


<210>  3986
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  3986

Met Val Gly Arg Asn Ser Ala Ile Ala Ala Gly Val Cys Gly Ala Leu 
1               5                   10                  15      


Phe Ile Gly Tyr Cys Ile Tyr Phe Asp Arg Lys Arg Arg Ser Asp Pro 
            20                  25                  30          


Asn Phe Lys Asn Arg Leu Arg Glu Arg Arg Lys Lys Gln Lys Leu Ala 
        35                  40                  45              


Lys Glu Arg Ala Gly Leu Ser Lys Leu Pro Asp Leu Lys Asp Ala Glu 
    50                  55                  60                  


Ala Val Gln Lys Phe Phe Leu Glu Glu Ile Gln Leu Gly Glu Glu Leu 
65                  70                  75                  80  


Leu Ala Gln Gly Glu Tyr Glu Lys Gly Val Asp His Leu Thr Asn Ala 
                85                  90                  95      


Ile Ala Val Cys Gly Gln Pro Gln Gln Leu Leu Gln Val Leu Gln Gln 
            100                 105                 110         


Thr Leu Pro Pro Pro Val Phe Gln Met Leu Leu Thr Lys Leu Pro Thr 
        115                 120                 125             


Ile Ser Gln Arg Ile Val Ser Ala Gln Ser Leu Ala Glu Asp Asp Val 
    130                 135                 140                 


Glu 
145 


<210>  3987
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  3987

Met Lys Lys Arg Lys Glu Leu Asn Ala Leu Ile Gly Leu Ala Gly Asp 
1               5                   10                  15      


Ser Arg Arg Lys Lys Pro Lys Lys Gly Pro Ser Ser His Arg Leu Leu 
            20                  25                  30          


Arg Thr Glu Pro Pro Asp Ser Asp Ser Glu Ser Ser Ser Glu Glu Glu 
        35                  40                  45              


Glu Glu Phe Gly Val Val Gly Asn Arg Ser Arg Phe Ala Lys Gly Asp 
    50                  55                  60                  


Tyr Leu Arg Cys Cys Lys Ile Cys Tyr Pro Leu Cys Gly Phe Val Ile 
65                  70                  75                  80  


Leu Ala Ala Cys Val Val Ala Cys Val Gly Leu Val Trp Met Gln Val 
                85                  90                  95      


Ala Leu Lys Glu Asp Leu Asp Ala Leu Lys Glu Lys Phe Arg Thr Met 
            100                 105                 110         


Glu Ser Asn Gln Lys Ser Ser Phe Gln Glu Ile Pro Lys Leu Asn Glu 
        115                 120                 125             


Glu Leu Leu Ser Lys Gln Lys Gln Leu Glu Lys Ile Glu Ser Gly Glu 
    130                 135                 140                 


Met Gly Leu Asn Lys Val Trp Ile Asn Ile Thr Glu Met Asn Lys Gln 
145                 150                 155                 160 


Ile Ser Leu Leu Thr Ser Ala Val Asn His Leu Lys Ala Asn Val Lys 
                165                 170                 175     


Ser Ala Ala Asp Leu Ile Ser Leu Pro Thr Thr Val Glu Gly Leu Gln 
            180                 185                 190         


Lys Ser Val Ala Ser Ile Gly Asn Thr Leu Asn Ser Val His Leu Ala 
        195                 200                 205             


Val Glu Ala Leu Gln Lys Thr Val Asp Glu His Lys Lys Thr Met Glu 
    210                 215                 220                 


Leu Leu Gln Ser Asp Met Asn Gln His Phe Leu Lys Glu Thr Pro Gly 
225                 230                 235                 240 


Ser Asn Gln Ile Ile Pro Ser Pro Ser Ala Thr Ser Glu Leu Asp Asn 
                245                 250                 255     


Lys Thr His Ser Glu Asn Leu Lys Gln Asp Ile Leu Tyr Leu His Asn 
            260                 265                 270         


Ser Leu Glu Glu Val Asn Ser Ala Leu Val Gly Tyr Gln Arg Gln Asn 
        275                 280                 285             


Asp Leu Lys Leu Glu Gly Met Asn Glu Thr Val Ser Asn Leu Thr Gln 
    290                 295                 300                 


Arg Val Asn Leu Ile Glu Ser Asp Val Val Ala Met Ser Lys Val Glu 
305                 310                 315                 320 


Lys Lys Ala Asn Leu Ser Phe Ser Met Met Gly Asp Arg Ser Ala Thr 
                325                 330                 335     


Leu Lys Arg Gln Ser Leu Asp Gln Val Thr Asn Arg Thr Asp Thr Val 
            340                 345                 350         


Lys Ile Gln Ser Ile Lys Lys Glu Asp Ser Ser Asn Ser Gln Val Ser 
        355                 360                 365             


Lys Leu Arg Glu Lys Leu Gln Leu Ile Ser Ala Leu Thr Asn Lys Pro 
    370                 375                 380                 


Glu Ser Asn Arg Pro Pro Glu Thr Ala Asp Glu Glu Gln Val Glu Ser 
385                 390                 395                 400 


Phe Thr Ser Lys Pro Ser Ala Leu Pro Lys Phe Ser Gln Phe Leu Gly 
                405                 410                 415     


Asp Pro Val Glu Lys Ala Ala Gln Leu Arg Pro Ile Ser Leu Pro Gly 
            420                 425                 430         


Val Ser Ser Thr Glu Asp Leu Gln Asp Leu Phe Arg Lys Thr Gly Gln 
        435                 440                 445             


Asp Val Asp Gly Lys Leu Thr Tyr Gln Glu Ile Trp Thr Ser Leu Gly 
    450                 455                 460                 


Ser Ala Met Pro Glu Pro Glu Ser Leu Arg Ala Phe Asp Ser Asp Gly 
465                 470                 475                 480 


Asp Gly Arg Tyr Ser Phe Leu Glu Leu Arg Val Ala Leu Gly Ile 
                485                 490                 495 


<210>  3988
<211>  632
<212>  PRT
<213>  Homo sapiens

<400>  3988

Met Ser Arg Val Arg Asp Ala Gly Cys Val Ala Ala Gly Ile Val Ile 
1               5                   10                  15      


Gly Ala Gly Ala Trp Tyr Cys Val Tyr Lys Tyr Thr Arg Gly Arg Asp 
            20                  25                  30          


Gln Thr Lys Lys Arg Met Ala Lys Pro Lys Asn Arg Ala Val Ala Gly 
        35                  40                  45              


Thr Gly Ala Arg Ala Arg Ala Gly Leu Arg Ala Gly Phe Thr Ile Asp 
    50                  55                  60                  


Leu Gly Ser Gly Phe Ser Pro Pro Thr Pro Val Arg Ala Glu Ala Glu 
65                  70                  75                  80  


Asp Arg Ala Gln Asp Glu Ala Ser Ala Leu Asp Thr Val Gly Ala Glu 
                85                  90                  95      


Ala Val Ala Pro Ala Ala Ser Ser Ala Glu Ala Gln Ser Gly Ala Gly 
            100                 105                 110         


Ser Gln Ala Gln Glu Ala Asp Gly Ala Gly Val Gly Pro Lys Ala Glu 
        115                 120                 125             


Ser Val Val Gly Ala Ala Met Ala Ser Ala Ile Ala Pro Pro Pro Gly 
    130                 135                 140                 


Val Thr Glu Ala Leu Gly Ala Ala Glu Ala Pro Ala Met Ala Gly Ala 
145                 150                 155                 160 


Pro Lys Val Ala Glu Ala Pro Arg Glu Ala Glu Thr Ser Arg Ala Ala 
                165                 170                 175     


Val Pro Pro Gly Thr Val Val Pro Thr Glu Ala Ala Ala Pro Thr Glu 
            180                 185                 190         


Val Thr Glu Gly Pro Gly Val Ala Ala Pro Thr Lys Val Ala Glu Ala 
        195                 200                 205             


Pro Gly Val Ala Ser Pro Thr Glu Ala Ala Glu Ala Pro Val Pro Ala 
    210                 215                 220                 


Thr Pro Thr Gly Ala Ala Ala Pro Thr Gly Ala Ala Glu Ser Pro Gly 
225                 230                 235                 240 


Thr Ser Gly Ser Pro Arg Thr Ala Val Val Pro Gly Thr Ser Ala Ala 
                245                 250                 255     


Lys Lys Ala Thr Pro Gly Ala His Thr Gly Ala Ile Pro Lys Ala Thr 
            260                 265                 270         


Ser Ala Thr Gly Ala Val Pro Lys Gly Gly Gly Lys Gly Val Thr Arg 
        275                 280                 285             


Ser Arg Asn Gly Gly Lys Gly Lys Gly Lys Lys Ser Lys Val Glu Val 
    290                 295                 300                 


Asp Glu Leu Gly Met Gly Phe Arg Pro Gly Asp Gly Ala Ala Ala Ala 
305                 310                 315                 320 


Ala Ala Ala Ser Ala Asn Gly Gly Gln Ala Phe Leu Ala Glu Val Pro 
                325                 330                 335     


Asp Ser Glu Glu Gly Glu Ser Gly Trp Thr Asp Thr Glu Ser Asp Ser 
            340                 345                 350         


Asp Ser Glu Pro Glu Thr Gln Arg Arg Gly Arg Gly Arg Arg Pro Val 
        355                 360                 365             


Ala Met Gln Lys Arg Pro Phe Pro Tyr Glu Ile Asp Glu Ile Leu Gly 
    370                 375                 380                 


Val Arg Asp Leu Arg Lys Val Leu Ala Leu Leu Gln Lys Ser Asp Asp 
385                 390                 395                 400 


Pro Phe Ile Gln Gln Val Ala Leu Leu Thr Leu Ser Asn Asn Ala Asn 
                405                 410                 415     


Tyr Ser Cys Asn Gln Glu Thr Ile Arg Lys Leu Gly Gly Leu Pro Ile 
            420                 425                 430         


Ile Ala Asn Met Ile Asn Lys Thr Asp Pro His Ile Lys Glu Lys Ala 
        435                 440                 445             


Leu Met Ala Met Asn Asn Leu Ser Glu Asn Tyr Glu Asn Gln Gly Arg 
    450                 455                 460                 


Leu Gln Val Tyr Met Asn Lys Val Met Asp Asp Ile Met Ala Ser Asn 
465                 470                 475                 480 


Leu Asn Ser Ala Val Gln Val Val Gly Leu Lys Phe Leu Thr Asn Met 
                485                 490                 495     


Thr Ile Thr Asn Asp Tyr Gln His Leu Leu Val Asn Ser Ile Ala Asn 
            500                 505                 510         


Phe Phe Arg Leu Leu Ser Gln Gly Gly Gly Lys Ile Lys Val Glu Ile 
        515                 520                 525             


Leu Lys Ile Leu Ser Asn Phe Ala Glu Asn Pro Asp Met Leu Lys Lys 
    530                 535                 540                 


Leu Leu Ser Thr Gln Val Pro Ala Ser Phe Ser Ser Leu Tyr Asn Ser 
545                 550                 555                 560 


Tyr Val Glu Ser Glu Ile Leu Ile Asn Ala Leu Thr Leu Phe Glu Ile 
                565                 570                 575     


Ile Tyr Asp Asn Leu Arg Ala Glu Val Phe Asn Tyr Arg Glu Phe Asn 
            580                 585                 590         


Lys Gly Ser Leu Phe Tyr Leu Cys Thr Thr Ser Gly Val Cys Val Lys 
        595                 600                 605             


Lys Ile Arg Ala Leu Ala Asn His His Asp Leu Leu Val Lys Val Lys 
    610                 615                 620                 


Val Ile Lys Leu Val Asn Lys Phe 
625                 630         


<210>  3989
<211>  891
<212>  PRT
<213>  Homo sapiens

<400>  3989

Met His Ala Ile Asn Gly Phe Val Phe Gly Asn Leu Pro Glu Leu Asn 
1               5                   10                  15      


Met Cys Ala Gln Lys Arg Val Ala Trp His Leu Phe Gly Met Gly Asn 
            20                  25                  30          


Glu Ile Asp Val His Thr Ala Phe Phe His Gly Gln Met Leu Thr Thr 
        35                  40                  45              


Arg Gly His His Thr Asp Val Ala Asn Ile Phe Pro Ala Thr Phe Val 
    50                  55                  60                  


Thr Ala Glu Met Val Pro Trp Glu Pro Gly Thr Trp Leu Ile Ser Cys 
65                  70                  75                  80  


Gln Val Asn Ser His Phe Arg Asp Gly Met Gln Ala Leu Tyr Lys Val 
                85                  90                  95      


Lys Ser Cys Ser Met Ala Pro Pro Val Asp Leu Leu Thr Gly Lys Val 
            100                 105                 110         


Arg Gln Tyr Phe Ile Glu Ala His Glu Ile Gln Trp Asp Tyr Gly Pro 
        115                 120                 125             


Met Gly His Asp Gly Ser Thr Gly Lys Asn Leu Arg Glu Pro Gly Ser 
    130                 135                 140                 


Ile Ser Asp Lys Phe Phe Gln Lys Ser Ser Ser Arg Ile Gly Gly Thr 
145                 150                 155                 160 


Tyr Trp Lys Val Arg Tyr Glu Ala Phe Gln Asp Glu Thr Phe Gln Glu 
                165                 170                 175     


Lys Met His Leu Glu Glu Asp Arg His Leu Gly Ile Leu Gly Pro Val 
            180                 185                 190         


Ile Arg Ala Glu Val Gly Asp Thr Ile Gln Val Val Phe Tyr Asn Arg 
        195                 200                 205             


Ala Ser Gln Pro Phe Ser Met Gln Pro His Gly Val Phe Tyr Glu Lys 
    210                 215                 220                 


Asp Tyr Glu Gly Thr Val Tyr Asn Asp Gly Ser Ser Tyr Pro Gly Leu 
225                 230                 235                 240 


Val Ala Lys Pro Phe Glu Lys Val Thr Tyr Arg Trp Thr Val Pro Pro 
                245                 250                 255     


His Ala Gly Pro Thr Ala Gln Asp Pro Ala Cys Leu Thr Trp Met Tyr 
            260                 265                 270         


Phe Ser Ala Ala Asp Pro Ile Arg Asp Thr Asn Ser Gly Leu Val Gly 
        275                 280                 285             


Pro Leu Leu Val Cys Arg Ala Gly Ala Leu Gly Ala Asp Gly Lys Gln 
    290                 295                 300                 


Lys Gly Val Asp Lys Glu Phe Phe Leu Leu Phe Thr Val Leu Asp Glu 
305                 310                 315                 320 


Asn Lys Ser Trp Tyr Ser Asn Ala Asn Gln Ala Ala Ala Met Leu Asp 
                325                 330                 335     


Phe Arg Leu Leu Ser Glu Asp Ile Glu Gly Phe Gln Asp Ser Asn Arg 
            340                 345                 350         


Met His Ala Ile Asn Gly Phe Leu Phe Ser Asn Leu Pro Arg Leu Asp 
        355                 360                 365             


Met Cys Lys Gly Asp Thr Val Ala Trp His Leu Leu Gly Leu Gly Thr 
    370                 375                 380                 


Glu Thr Asp Val His Gly Val Met Phe Gln Gly Asn Thr Val Gln Leu 
385                 390                 395                 400 


Gln Gly Met Arg Lys Gly Ala Ala Met Leu Phe Pro His Thr Phe Val 
                405                 410                 415     


Met Ala Ile Met Gln Pro Asp Asn Leu Gly Thr Phe Glu Ile Tyr Cys 
            420                 425                 430         


Gln Ala Gly Ser His Arg Glu Ala Gly Met Arg Ala Ile Tyr Asn Val 
        435                 440                 445             


Ser Gln Cys Pro Gly His Gln Ala Thr Pro Arg Gln Arg Tyr Gln Ala 
    450                 455                 460                 


Ala Arg Ile Tyr Tyr Ile Met Ala Glu Glu Val Glu Trp Asp Tyr Cys 
465                 470                 475                 480 


Pro Asp Arg Ser Trp Glu Arg Glu Trp His Asn Gln Ser Glu Lys Asp 
                485                 490                 495     


Ser Tyr Gly Tyr Ile Phe Leu Ser Asn Lys Asp Gly Leu Leu Gly Ser 
            500                 505                 510         


Arg Tyr Lys Lys Ala Val Phe Arg Glu Tyr Thr Asp Gly Thr Phe Arg 
        515                 520                 525             


Ile Pro Arg Pro Arg Thr Gly Pro Glu Glu His Leu Gly Ile Leu Gly 
    530                 535                 540                 


Pro Leu Ile Lys Gly Glu Val Gly Asp Ile Leu Thr Val Val Phe Lys 
545                 550                 555                 560 


Asn Asn Ala Ser Arg Pro Tyr Ser Val His Ala His Gly Val Leu Glu 
                565                 570                 575     


Ser Thr Thr Val Trp Pro Leu Ala Ala Glu Pro Gly Glu Val Val Thr 
            580                 585                 590         


Tyr Gln Trp Asn Ile Pro Glu Arg Ser Gly Pro Gly Pro Asn Asp Ser 
        595                 600                 605             


Ala Cys Val Ser Trp Ile Tyr Tyr Ser Ala Val Asp Pro Ile Lys Asp 
    610                 615                 620                 


Met Tyr Ser Gly Leu Val Gly Pro Leu Ala Ile Cys Gln Lys Gly Ile 
625                 630                 635                 640 


Leu Glu Pro His Gly Gly Arg Ser Asp Met Asp Arg Glu Phe Ala Leu 
                645                 650                 655     


Leu Phe Leu Ile Phe Asp Glu Asn Lys Ser Trp Tyr Leu Glu Glu Asn 
            660                 665                 670         


Val Ala Thr His Gly Ser Gln Asp Pro Gly Ser Ile Asn Leu Gln Asp 
        675                 680                 685             


Glu Thr Phe Leu Glu Ser Asn Lys Met His Ala Ile Asn Gly Lys Leu 
    690                 695                 700                 


Tyr Ala Asn Leu Arg Gly Leu Thr Met Tyr Gln Gly Glu Arg Val Ala 
705                 710                 715                 720 


Trp Tyr Met Leu Ala Met Gly Gln Asp Val Asp Leu His Thr Ile His 
                725                 730                 735     


Phe His Ala Glu Ser Phe Leu Tyr Arg Asn Gly Glu Asn Tyr Arg Ala 
            740                 745                 750         


Asp Val Val Asp Leu Phe Pro Gly Thr Phe Glu Val Val Glu Met Val 
        755                 760                 765             


Ala Ser Asn Pro Gly Thr Trp Leu Met His Cys His Val Thr Asp His 
    770                 775                 780                 


Val His Ala Gly Met Glu Thr Leu Phe Thr Val Phe Ser Arg Thr Glu 
785                 790                 795                 800 


His Leu Ser Pro Leu Thr Val Ile Thr Lys Glu Thr Glu Lys Ala Val 
                805                 810                 815     


Pro Pro Arg Asp Ile Glu Glu Gly Asn Val Lys Met Leu Gly Met Gln 
            820                 825                 830         


Ile Pro Ile Lys Asn Val Glu Met Leu Ala Ser Val Leu Val Ala Ile 
        835                 840                 845             


Ser Val Thr Leu Leu Leu Val Val Leu Ala Leu Gly Gly Val Val Trp 
    850                 855                 860                 


Tyr Gln His Arg Gln Arg Lys Leu Arg Arg Asn Arg Arg Ser Ile Leu 
865                 870                 875                 880 


Asp Asp Ser Phe Lys Leu Leu Ser Phe Lys Gln 
                885                 890     


<210>  3990
<211>  2137
<212>  PRT
<213>  Homo sapiens

<400>  3990

Met Val Ser Gln Val Leu Gln Leu Leu Arg Gln Gly Val Trp Ala Ala 
1               5                   10                  15      


Leu Thr Gly Gly Trp Tyr His Asp Pro Glu Gln Ser Lys Phe Thr Asn 
            20                  25                  30          


Ser Cys His Leu Tyr Leu Trp Leu Phe Leu Leu Leu Leu Pro Leu Ala 
        35                  40                  45              


Leu His Leu Ala Phe Pro Pro Asn Ala Ile Ile Val Phe Phe Tyr Cys 
    50                  55                  60                  


Ser Ala Val Thr Ile Phe Phe Thr Ile Ile Lys Leu Val Ser Tyr Arg 
65                  70                  75                  80  


Leu His Leu Met Phe Asp Lys Gly Glu Val Ile Gln Gln Lys Pro Ser 
                85                  90                  95      


Arg Lys Glu Glu Lys Pro Asn Lys Asp Lys Glu Ala Lys Gly Glu His 
            100                 105                 110         


Ile Thr Asn His Arg Asn Pro Ser Asn Asn Arg Gln Ile His Asn Gly 
        115                 120                 125             


Lys Lys Glu Glu Ala Ser Arg Asn Leu Ser Thr Pro Pro Leu Arg Cys 
    130                 135                 140                 


Ser Ser Arg Gly Gln Ser Ile Thr Ser His His Ser Ser Gly Pro Leu 
145                 150                 155                 160 


Glu Leu Ser Ala Gln Glu Thr Val Glu Asp Leu Lys Gly Val Ile Leu 
                165                 170                 175     


Leu Glu Asp His Pro Ile Ala Pro Val Ser Ser Thr Ser Pro Gly Ile 
            180                 185                 190         


Lys Val Glu Ser Leu Pro Ala Ser Gln Ala His Met Leu Glu Thr Thr 
        195                 200                 205             


Thr Lys Ser Val Ile Pro Val Lys Pro Val Ala Thr Glu Thr Leu Ile 
    210                 215                 220                 


Asn Gly Lys Gly Lys Glu Arg Gly Gly Lys Gly Gln Pro Pro Leu Arg 
225                 230                 235                 240 


His Arg Ser Glu Gly Gly Leu Val Asp Lys Gly Pro Leu Lys Lys Leu 
                245                 250                 255     


Pro His Leu Ser Leu Ser Gln Tyr Asp Leu Leu Glu Thr Asp Val Ser 
            260                 265                 270         


Phe Gln Pro Trp Gly Ser Glu Asn Ser Val Leu Ile Pro Glu Pro Val 
        275                 280                 285             


Ser Cys Pro Arg Gly Ser Ile Arg Glu Arg Val Gln Ser Lys Ser Pro 
    290                 295                 300                 


Gln Asp Ser Leu Ser Ser Ser Cys Pro Gln Cys Asp Thr Ile Val Ala 
305                 310                 315                 320 


Lys Pro Val Glu Glu Pro Ala Asp Thr Ser Cys Gln Val Asp Thr Ser 
                325                 330                 335     


Cys Gln Gly Asp Leu Pro Leu His Gln Glu Val Asp Ser Ser Asp Ser 
            340                 345                 350         


Glu Val Ala Val Thr Leu Ile Asp Thr Ser Gln Pro Gly Asp Pro Leu 
        355                 360                 365             


Ser Leu His Glu Pro Ile Lys Ile Val Ile Thr Met Ser Ser Thr Pro 
    370                 375                 380                 


Asn Ser Met Thr Asp Leu Glu Ser Ser Leu His Leu Arg Val Val Gly 
385                 390                 395                 400 


Thr Glu Lys Thr Ser Val Lys Ser Asp Ala Glu Pro Thr Asn Pro Gly 
                405                 410                 415     


Ala Ala Gly Ser Pro Asn Ala Glu Gln Ile Ser Ile Pro Val Ile Thr 
            420                 425                 430         


Leu Asp Leu Pro Glu Gly Gly Gly Gly Gly Val Pro Cys Pro Glu Gly 
        435                 440                 445             


Asn Gly Ser Glu Arg Thr Pro Glu Arg Leu Lys Thr Arg Val Ser Thr 
    450                 455                 460                 


Asn Gln Cys Ser Gly Tyr Gly Ser Gly Glu Gly Gly Asn Ala Ile Lys 
465                 470                 475                 480 


Asp His Ser Ser Ser Ser Arg Glu Pro Trp Glu Ser Val Ser Arg Leu 
                485                 490                 495     


Thr Pro Asp Thr Gly Ser Glu Ser Lys Val Gly Lys Glu Gly Gln Thr 
            500                 505                 510         


Asn Leu Asp Pro Ser Ser Cys Lys Ser Ser His Glu Lys Arg His Ala 
        515                 520                 525             


Arg Val Leu Ser Val Asp Ser Gly Thr Asp Val Phe Leu Ser Lys Ser 
    530                 535                 540                 


Ser Ala Glu Ile Val Asn Asp Thr Glu Lys Thr Met Pro Thr Ser Lys 
545                 550                 555                 560 


Ser Asp Leu Glu Ala Lys Glu Gly Gln Met Pro Asn Glu Ser Asn Phe 
                565                 570                 575     


Leu Glu Phe Val Ser Leu Leu Glu Ser Ile Asn Thr Ser Lys Met Thr 
            580                 585                 590         


Ala Ser Ser Gln Leu Asn Gly Ser Ala Glu Gln Asn Glu Glu Ser Gly 
        595                 600                 605             


Leu Leu Arg Asp Asn Cys Ser Gln Glu Lys Lys Glu Glu Ile Leu Glu 
    610                 615                 620                 


Asn Glu Lys Pro Ser Gly His Ser Ser Lys Gln Gly Lys Pro Asp Leu 
625                 630                 635                 640 


Gln Ser Gln Asp His Thr Ser Thr Gly Pro Ala Cys Thr Gln Pro Ala 
                645                 650                 655     


Lys Thr Thr Ala Phe Phe Gln Gly Asn Arg Gln Arg Gln Ile Ile Tyr 
            660                 665                 670         


Arg Val Thr Ser Gln Gln Asp Ser Ser Val Leu Gln Val Ile Ser Gly 
        675                 680                 685             


Pro Glu Thr Ser Val Gln Glu Glu Ile Ser Val Asp Ala Met His Val 
    690                 695                 700                 


Phe Ile Asp Glu His Gly Glu Ile Arg Ser Cys Tyr Leu Lys Ser Gly 
705                 710                 715                 720 


Asn Gln Lys Glu Gly Pro Leu Gln Pro Leu Pro Ser Asn Asn Asp Cys 
                725                 730                 735     


Leu Ser Gln Ala Arg Glu Met Gln Val Ser Ser Ser Ser Thr Thr Thr 
            740                 745                 750         


Ser Glu Ser Gln Asp Pro Ser Ser Gly Asp Pro Ala Val Ser Ala Leu 
        755                 760                 765             


Gln Gln Gln Leu Leu Leu Met Val Ala Arg Arg Thr Gln Ser Glu Thr 
    770                 775                 780                 


Pro Arg His Val Ser Gln Asp Leu Glu Ala Ser Ser Cys Ser Ser Thr 
785                 790                 795                 800 


Gln Gly Lys Phe Asn Arg Glu Gln Phe Tyr Lys Phe Ile Ile Phe Pro 
                805                 810                 815     


Gly Lys Trp Ile Lys Val Trp Tyr Asp Arg Leu Thr Leu Leu Ala Leu 
            820                 825                 830         


Leu Asp Arg Thr Glu Asp Ile Lys Glu Asn Val Leu Ala Ile Leu Leu 
        835                 840                 845             


Ile Val Leu Val Ser Leu Leu Gly Phe Leu Thr Leu Ser Gln Gly Phe 
    850                 855                 860                 


Cys Lys Asp Met Trp Val Leu Leu Phe Cys Leu Val Met Ala Ser Cys 
865                 870                 875                 880 


Gln Tyr Ser Leu Leu Lys Ser Val Gln Pro Asp Pro Ala Ser Pro Ile 
                885                 890                 895     


His Gly His Asn Gln Ile Ile Thr Tyr Ser Arg Pro Ile Tyr Phe Cys 
            900                 905                 910         


Val Leu Cys Gly Leu Ile Leu Leu Leu Asp Thr Gly Ala Lys Ala Arg 
        915                 920                 925             


His Pro Pro Ser Tyr Val Val Tyr Gly Leu Lys Leu Phe Ser Pro Val 
    930                 935                 940                 


Phe Leu Gln Ser Ala Arg Asp Tyr Leu Ile Val Phe Leu Tyr Cys Phe 
945                 950                 955                 960 


Pro Ala Ile Ser Leu Leu Gly Leu Phe Pro Gln Ile Asn Thr Phe Cys 
                965                 970                 975     


Thr Tyr Leu Leu Glu Gln Ile Asp Met Leu Phe Phe Gly Gly Ser Ala 
            980                 985                 990         


Val Ser Gly Ile Thr Ser Ala Val  Tyr Ser Val Ala Arg  Ser Val Leu 
        995                 1000                 1005             


Ala Ala  Ala Leu Leu His Ala  Val Cys Phe Ser Ala  Val Lys Glu 
    1010                 1015                 1020             


Pro Trp  Ser Met Gln His Ile  Pro Ala Leu Phe Ser  Ala Phe Cys 
    1025                 1030                 1035             


Gly Leu  Leu Val Ala Leu Ser  Tyr His Leu Ser Arg  Gln Ser Ser 
    1040                 1045                 1050             


Asp Pro  Ser Val Leu Met Ser  Phe Ile Gln Cys Arg  Leu Phe Pro 
    1055                 1060                 1065             


Lys Phe  Leu His Gln Asn Leu  Ala Glu Ser Ala Ala  Asp Pro Leu 
    1070                 1075                 1080             


Pro Lys  Lys Met Lys Asp Ser  Val Thr Asp Val Leu  Lys Trp Asp 
    1085                 1090                 1095             


Leu Ile  Val Cys Ala Val Val  Ala Val Leu Ser Phe  Ala Val Ser 
    1100                 1105                 1110             


Ala Ser  Thr Val Phe Leu Ser  Leu Arg Pro Phe Leu  Ser Ile Val 
    1115                 1120                 1125             


Leu Phe  Ala Leu Ala Gly Ala  Val Gly Phe Val Thr  His Tyr Val 
    1130                 1135                 1140             


Leu Pro  Gln Leu Arg Lys His  His Pro Trp Met Trp  Ile Ser His 
    1145                 1150                 1155             


Pro Ile  Leu Lys Asn Lys Glu  Tyr His Gln Arg Glu  Val Arg Asp 
    1160                 1165                 1170             


Val Ala  His Leu Met Trp Phe  Glu Arg Leu Tyr Val  Trp Leu Gln 
    1175                 1180                 1185             


Cys Phe  Glu Lys Tyr Ile Leu  Tyr Pro Ala Leu Ile  Leu Asn Ala 
    1190                 1195                 1200             


Leu Thr  Ile Asp Ala Phe Leu  Ile Ser Asn His Arg  Arg Leu Gly 
    1205                 1210                 1215             


Thr His  Trp Asp Ile Phe Leu  Met Ile Ile Ala Gly  Met Lys Leu 
    1220                 1225                 1230             


Leu Arg  Thr Ser Phe Cys Asn  Pro Val Tyr Gln Phe  Ile Asn Leu 
    1235                 1240                 1245             


Ser Phe  Thr Val Ile Phe Phe  His Phe Asp Tyr Lys  Asp Ile Ser 
    1250                 1255                 1260             


Glu Ser  Phe Leu Leu Asp Phe  Phe Met Val Ser Ile  Leu Phe Ser 
    1265                 1270                 1275             


Lys Leu  Gly Asp Leu Leu His  Lys Leu Gln Phe Val  Leu Thr Tyr 
    1280                 1285                 1290             


Val Ala  Pro Trp Gln Met Ala  Trp Gly Ser Ser Phe  His Val Phe 
    1295                 1300                 1305             


Ala Gln  Leu Phe Ala Ile Pro  His Ser Ala Met Leu  Phe Phe Gln 
    1310                 1315                 1320             


Thr Ile  Ala Thr Ser Ile Phe  Ser Thr Pro Leu Ser  Pro Phe Leu 
    1325                 1330                 1335             


Gly Ser  Val Ile Phe Ile Thr  Ser Tyr Val Arg Pro  Val Lys Phe 
    1340                 1345                 1350             


Trp Glu  Lys Asn Tyr Asn Thr  Arg Arg Val Asp Asn  Ser Asn Thr 
    1355                 1360                 1365             


Arg Leu  Ala Val Gln Ile Glu  Arg Asp Pro Gly Asn  Asp Asp Asn 
    1370                 1375                 1380             


Asn Leu  Asn Ser Ile Phe Tyr  Glu His Leu Thr Arg  Thr Leu Gln 
    1385                 1390                 1395             


Glu Ser  Leu Cys Gly Asp Leu  Val Leu Gly Arg Trp  Gly Asn Tyr 
    1400                 1405                 1410             


Ser Ser  Gly Asp Cys Phe Ile  Leu Ala Ser Asp Asp  Leu Asn Ala 
    1415                 1420                 1425             


Phe Val  His Leu Ile Glu Ile  Gly Asn Gly Leu Val  Thr Phe Gln 
    1430                 1435                 1440             


Leu Arg  Gly Leu Glu Phe Arg  Gly Thr Tyr Cys Gln  Gln Arg Glu 
    1445                 1450                 1455             


Val Glu  Ala Ile Met Glu Gly  Asp Glu Glu Asp Arg  Gly Cys Cys 
    1460                 1465                 1470             


Cys Cys  Lys Pro Gly His Leu  Pro His Leu Leu Ser  Cys Asn Ala 
    1475                 1480                 1485             


Ala Phe  His Leu Arg Trp Leu  Thr Trp Glu Ile Thr  Gln Thr Gln 
    1490                 1495                 1500             


Tyr Ile  Leu Glu Gly Tyr Ser  Ile Leu Asp Asn Asn  Ala Ala Thr 
    1505                 1510                 1515             


Met Leu  Gln Val Phe Asp Leu  Arg Arg Ile Leu Ile  Arg Tyr Tyr 
    1520                 1525                 1530             


Ile Lys  Ser Ile Ile Tyr Tyr  Met Val Thr Ser Pro  Lys Leu Leu 
    1535                 1540                 1545             


Ser Trp  Ile Lys Asn Glu Ser  Leu Leu Lys Ser Leu  Gln Pro Phe 
    1550                 1555                 1560             


Ala Lys  Trp His Tyr Ile Glu  Arg Asp Leu Ala Met  Phe Asn Ile 
    1565                 1570                 1575             


Asn Ile  Asp Asp Asp Tyr Val  Pro Cys Leu Gln Gly  Ile Thr Arg 
    1580                 1585                 1590             


Ala Ser  Phe Cys Asn Val Tyr  Leu Glu Trp Ile Gln  His Cys Ala 
    1595                 1600                 1605             


Arg Lys  Arg Gln Glu Pro Ser  Thr Thr Leu Asp Ser  Asp Glu Asp 
    1610                 1615                 1620             


Ser Pro  Leu Val Thr Leu Ser  Phe Ala Leu Cys Thr  Leu Gly Arg 
    1625                 1630                 1635             


Arg Ala  Leu Gly Thr Ala Ala  His Asn Met Ala Ile  Ser Leu Asp 
    1640                 1645                 1650             


Ser Phe  Leu Tyr Gly Leu His  Val Leu Phe Lys Gly  Asp Phe Arg 
    1655                 1660                 1665             


Ile Thr  Ala Arg Asp Glu Trp  Val Phe Ala Asp Met  Asp Leu Leu 
    1670                 1675                 1680             


His Lys  Val Val Ala Pro Ala  Ile Arg Met Ser Leu  Lys Leu His 
    1685                 1690                 1695             


Gln Asp  Gln Phe Thr Cys Pro  Asp Glu Tyr Glu Asp  Pro Ala Val 
    1700                 1705                 1710             


Leu Tyr  Glu Ala Ile Gln Ser  Phe Glu Lys Lys Val  Val Ile Cys 
    1715                 1720                 1725             


His Glu  Gly Asp Pro Ala Trp  Arg Gly Ala Val Leu  Ser Asn Lys 
    1730                 1735                 1740             


Glu Glu  Leu Leu Thr Leu Arg  His Val Val Asp Glu  Gly Ala Asp 
    1745                 1750                 1755             


Glu Tyr  Lys Val Ile Met Leu  His Arg Ser Phe Leu  Ser Phe Lys 
    1760                 1765                 1770             


Val Ile  Lys Val Asn Lys Glu  Cys Val Arg Gly Leu  Trp Ala Gly 
    1775                 1780                 1785             


Gln Gln  Gln Glu Leu Ile Phe  Leu Arg Asn Arg Asn  Pro Glu Arg 
    1790                 1795                 1800             


Gly Ser  Ile Gln Asn Asn Lys  Gln Val Leu Arg Asn  Leu Ile Asn 
    1805                 1810                 1815             


Ser Ser  Cys Asp Gln Pro Leu  Gly Tyr Pro Met Tyr  Val Ser Pro 
    1820                 1825                 1830             


Leu Thr  Thr Ser Tyr Leu Gly  Thr His Arg Gln Leu  Lys Asn Ile 
    1835                 1840                 1845             


Trp Gly  Gly Pro Ile Thr Leu  Asp Arg Ile Arg Thr  Trp Phe Trp 
    1850                 1855                 1860             


Thr Lys  Trp Val Arg Met Arg  Lys Asp Cys Asn Ala  Arg Gln His 
    1865                 1870                 1875             


Ser Gly  Gly Asn Ile Glu Asp  Val Asp Gly Gly Gly  Ala Pro Thr 
    1880                 1885                 1890             


Thr Gly  Gly Asn Asn Ala Pro  Ser Gly Gly Ser Gln  Glu Ser Ser 
    1895                 1900                 1905             


Ala Glu  Gln Pro Arg Lys Gly  Gly Ala Gln His Gly  Val Ser Ser 
    1910                 1915                 1920             


Cys Glu  Gly Thr Gln Arg Thr  Gly Arg Arg Lys Gly  Arg Ser Gln 
    1925                 1930                 1935             


Ser Val  Gln Ala His Ser Ala  Leu Ser Gln Arg Pro  Pro Met Leu 
    1940                 1945                 1950             


Ser Ser  Ser Gly Pro Ile Leu  Glu Ser Arg Gln Thr  Phe Leu Gln 
    1955                 1960                 1965             


Thr Ser  Thr Ser Val His Glu  Leu Ala Gln Arg Leu  Ser Gly Ser 
    1970                 1975                 1980             


Arg Leu  Ser Leu His Ala Ser  Ala Thr Ser Leu His  Ser Gln Pro 
    1985                 1990                 1995             


Pro Pro  Val Thr Thr Thr Gly  His Leu Ser Val Arg  Glu Arg Ala 
    2000                 2005                 2010             


Glu Ala  Leu Ile Arg Ser Ser  Leu Gly Ser Ser Thr  Ser Ser Thr 
    2015                 2020                 2025             


Leu Ser  Phe Leu Phe Gly Lys  Arg Ser Phe Ser Ser  Ala Leu Val 
    2030                 2035                 2040             


Ile Ser  Gly Leu Ser Ala Ala  Glu Gly Gly Asn Thr  Ser Asp Thr 
    2045                 2050                 2055             


Gln Ser  Ser Ser Ser Val Asn  Ile Val Met Gly Pro  Ser Ala Arg 
    2060                 2065                 2070             


Ala Ala  Ser Gln Ala Thr Arg  His Leu Ser Glu Pro  Cys Glu Pro 
    2075                 2080                 2085             


Pro Asp  Ala Thr Glu Gln Gly  Gln Leu His Asp Arg  Cys Leu Ala 
    2090                 2095                 2100             


Glu Ala  Val Ala Asp Thr Leu  Gly Val Val Cys Arg  Arg Ala Ser 
    2105                 2110                 2115             


Gln Glu  Asp Met Gly Leu Asp  Asp Thr Ala Ser Gln  Gln Ser Val 
    2120                 2125                 2130             


Ser Asp  Glu Gln 
    2135         


<210>  3991
<211>  1000
<212>  PRT
<213>  Homo sapiens

<400>  3991

Met Pro Gly Lys Leu Lys Val Lys Ile Val Ala Gly Arg His Leu Pro 
1               5                   10                  15      


Val Met Asp Arg Ala Ser Asp Leu Thr Asp Ala Phe Val Glu Val Lys 
            20                  25                  30          


Phe Gly Asn Thr Thr Phe Lys Thr Asp Val Tyr Leu Lys Ser Leu Asn 
        35                  40                  45              


Pro Gln Trp Asn Ser Glu Trp Phe Lys Phe Glu Val Asp Asp Glu Asp 
    50                  55                  60                  


Leu Gln Asp Glu Pro Leu Gln Ile Thr Val Leu Asp His Asp Thr Tyr 
65                  70                  75                  80  


Ser Ala Asn Asp Ala Ile Gly Lys Val Tyr Ile Asp Ile Asp Pro Leu 
                85                  90                  95      


Leu Tyr Ser Glu Ala Ala Thr Val Ile Ser Gly Trp Phe Pro Ile Tyr 
            100                 105                 110         


Asp Thr Ile His Gly Ile Arg Gly Glu Ile Asn Val Val Val Lys Val 
        115                 120                 125             


Asp Leu Phe Asn Asp Leu Asn Arg Phe Arg Gln Ser Ser Cys Gly Val 
    130                 135                 140                 


Lys Phe Phe Cys Thr Thr Ser Ile Pro Lys Cys Tyr Arg Ala Val Ile 
145                 150                 155                 160 


Ile His Gly Phe Val Glu Glu Leu Val Val Asn Glu Asp Pro Glu Tyr 
                165                 170                 175     


Gln Trp Ile Asp Arg Ile Arg Thr Pro Arg Ala Ser Asn Glu Ala Arg 
            180                 185                 190         


Gln Arg Leu Ile Ser Leu Met Ser Gly Glu Leu Gln Arg Lys Ile Gly 
        195                 200                 205             


Leu Lys Val Leu Glu Met Arg Gly Asn Ala Val Val Gly Tyr Leu Gln 
    210                 215                 220                 


Cys Phe Asp Leu Glu Gly Glu Ser Gly Leu Val Val Arg Ala Ile Gly 
225                 230                 235                 240 


Thr Ala Cys Thr Leu Asp Lys Leu Ser Ser Pro Ala Ala Phe Leu Pro 
                245                 250                 255     


Ala Cys Asn Ser Pro Ser Lys Glu Met Lys Glu Ile Pro Phe Asn Glu 
            260                 265                 270         


Asp Pro Asn Pro Asn Thr His Ser Ser Gly Pro Ser Thr Pro Leu Lys 
        275                 280                 285             


Asn Gln Thr Tyr Ser Phe Ser Pro Ser Lys Ser Tyr Ser Arg Gln Ser 
    290                 295                 300                 


Ser Ser Ser Asp Thr Asp Leu Ser Leu Thr Pro Lys Thr Gly Met Gly 
305                 310                 315                 320 


Ser Gly Ser Ala Gly Lys Glu Gly Gly Pro Phe Lys Ala Leu Leu Arg 
                325                 330                 335     


Gln Gln Thr Gln Ser Ala Leu Glu Gln Arg Glu Phe Pro Phe Phe Thr 
            340                 345                 350         


Leu Thr Ala Phe Pro Pro Gly Phe Leu Val His Val Gly Gly Val Val 
        355                 360                 365             


Ser Ala Arg Ser Val Lys Leu Leu Asp Arg Ile His Asn Pro Asp Glu 
    370                 375                 380                 


Pro Glu Thr Arg Asp Ala Trp Trp Ala Glu Ile Arg Gln Glu Ile Lys 
385                 390                 395                 400 


Ser His Ala Lys Ala Leu Gly Cys His Ala Val Val Gly Tyr Ser Glu 
                405                 410                 415     


Ser Thr Ser Ile Cys Glu Glu Val Cys Ile Leu Ser Ala Ser Gly Thr 
            420                 425                 430         


Ala Ala Val Leu Asn Pro Arg Phe Leu Gln Asp Gly Thr Val Glu Gly 
        435                 440                 445             


Cys Leu Glu Gln Arg Leu Glu Glu Asn Leu Pro Thr Arg Cys Gly Phe 
    450                 455                 460                 


Cys His Ile Pro Tyr Asp Glu Leu Asn Met Pro Phe Pro Ala His Leu 
465                 470                 475                 480 


Thr Tyr Cys Tyr Asn Cys Arg Lys Gln Lys Val Pro Asp Val Leu Phe 
                485                 490                 495     


Thr Thr Ile Asp Leu Pro Thr Asp Ala Thr Val Ile Gly Lys Gly Cys 
            500                 505                 510         


Leu Ile Gln Ala Arg Leu Cys Arg Leu Lys Lys Lys Ala Gln Ala Glu 
        515                 520                 525             


Ala Asn Ala Thr Ala Ile Ser Asn Leu Leu Pro Phe Met Glu Tyr Glu 
    530                 535                 540                 


Val His Thr Gln Leu Met Asn Lys Leu Lys Leu Lys Gly Met Asn Ala 
545                 550                 555                 560 


Leu Phe Gly Leu Arg Ile Gln Ile Thr Val Gly Glu Asn Met Leu Met 
                565                 570                 575     


Gly Leu Ala Ser Ala Thr Gly Val Tyr Leu Ala Ala Leu Pro Thr Pro 
            580                 585                 590         


Gly Gly Ile Gln Ile Ala Gly Lys Thr Pro Asn Asp Gly Ser Tyr Glu 
        595                 600                 605             


Gln His Ile Ser His Met Gln Lys Lys Ile Asn Asp Thr Ile Ala Lys 
    610                 615                 620                 


Asn Lys Glu Leu Tyr Glu Ile Asn Pro Pro Glu Ile Ser Glu Glu Ile 
625                 630                 635                 640 


Ile Gly Ser Pro Ile Pro Glu Pro Arg Gln Arg Ser Arg Leu Leu Arg 
                645                 650                 655     


Ser Gln Ser Glu Ser Ser Asp Glu Val Thr Glu Leu Asp Leu Ser His 
            660                 665                 670         


Gly Lys Lys Asp Ala Phe Val Leu Glu Ile Asp Asp Thr Asp Ala Met 
        675                 680                 685             


Glu Asp Val His Ser Leu Leu Thr Asp Val Pro Pro Pro Ser Gly Phe 
    690                 695                 700                 


Tyr Ser Cys Asn Thr Glu Ile Met Pro Gly Ile Asn Asn Trp Thr Ser 
705                 710                 715                 720 


Glu Ile Gln Met Phe Thr Ser Val Arg Val Ile Arg Leu Ser Ser Leu 
                725                 730                 735     


Asn Leu Thr Asn Gln Ala Leu Asn Lys Asn Phe Asn Asp Leu Cys Glu 
            740                 745                 750         


Asn Leu Leu Lys Ser Leu Tyr Phe Lys Leu Arg Ser Met Ile Pro Cys 
        755                 760                 765             


Cys Leu Cys His Val Asn Phe Thr Val Ser Leu Pro Glu Asp Glu Leu 
    770                 775                 780                 


Ile Gln Val Thr Val Thr Ala Val Ala Ile Thr Phe Asp Lys Asn Gln 
785                 790                 795                 800 


Ala Leu Gln Thr Thr Lys Thr Pro Val Glu Lys Ser Leu Gln Arg Ala 
                805                 810                 815     


Ser Thr Asp Asn Glu Glu Leu Leu Gln Phe Pro Leu Glu Leu Cys Ser 
            820                 825                 830         


Asp Ser Leu Pro Ser His Pro Phe Pro Pro Ala Lys Ala Met Thr Val 
        835                 840                 845             


Glu Lys Ala Ser Pro Val Gly Asp Gly Asn Phe Arg Asn Arg Ser Ala 
    850                 855                 860                 


Pro Pro Cys Ala Asn Ser Thr Val Gly Val Val Lys Met Thr Pro Leu 
865                 870                 875                 880 


Ser Phe Ile Pro Gly Ala Lys Ile Thr Lys Tyr Leu Gly Ile Ile Asn 
                885                 890                 895     


Met Phe Phe Ile Arg Glu Thr Thr Ser Leu Arg Glu Glu Gly Gly Val 
            900                 905                 910         


Ser Gly Phe Leu His Ala Phe Ile Ala Glu Val Phe Ala Met Val Arg 
        915                 920                 925             


Ala His Val Ala Ala Leu Gly Gly Asn Ala Val Val Ser Tyr Ile Met 
    930                 935                 940                 


Lys Gln Cys Val Phe Met Glu Asn Pro Asn Lys Asn Gln Ala Gln Cys 
945                 950                 955                 960 


Leu Ile Asn Val Ser Gly Asp Ala Val Val Phe Val Arg Glu Ser Asp 
                965                 970                 975     


Leu Glu Val Val Ser Ser Gln Gln Pro Thr Thr Asn Cys Gln Ser Ser 
            980                 985                 990         


Cys Thr Glu Gly Glu Val Thr Thr  
        995                 1000 


<210>  3992
<211>  707
<212>  PRT
<213>  Homo sapiens

<400>  3992

Met Asp Pro Gly Trp Gly Gln Arg Asp Val Gly Trp Ala Ala Leu Leu 
1               5                   10                  15      


Ile Leu Phe Ala Ala Ser Leu Leu Thr Val Phe Ala Trp Leu Leu Gln 
            20                  25                  30          


Tyr Ala Arg Gly Leu Trp Leu Ala Arg Ala Arg Gly Asp Arg Gly Pro 
        35                  40                  45              


Gly Pro Ala Leu Ala Gly Glu Pro Ala Gly Ser Leu Arg Glu Leu Gly 
    50                  55                  60                  


Val Trp Arg Ser Leu Leu Arg Leu Arg Ala Thr Arg Ala Gly Ala Ala 
65                  70                  75                  80  


Glu Glu Pro Gly Val Arg Gly Leu Leu Ala Ser Leu Phe Ala Phe Lys 
                85                  90                  95      


Ser Phe Arg Glu Asn Trp Gln Arg Ala Trp Val Arg Ala Leu Asn Glu 
            100                 105                 110         


Gln Ala Cys Arg Asn Gly Ser Ser Ile Gln Ile Ala Phe Glu Glu Val 
        115                 120                 125             


Pro Gln Leu Pro Pro Arg Ala Ser Ile Ser His Val Thr Cys Val Asp 
    130                 135                 140                 


Gln Ser Glu His Thr Met Val Leu Arg Cys Gln Leu Ser Ala Glu Glu 
145                 150                 155                 160 


Val Arg Phe Pro Val Ser Val Thr Gln Gln Ser Pro Ala Ala Val Ser 
                165                 170                 175     


Met Glu Thr Tyr His Val Thr Leu Thr Leu Pro Pro Thr Gln Leu Glu 
            180                 185                 190         


Val Asn Leu Glu Glu Ile Pro Gly Glu Gly Leu Leu Ile Ser Trp Ala 
        195                 200                 205             


Phe Thr Asp Arg Pro Asp Leu Ser Leu Thr Val Leu Pro Lys Leu Gln 
    210                 215                 220                 


Ala Arg Glu Arg Gly Glu Glu Gln Val Glu Leu Ser Thr Ile Glu Glu 
225                 230                 235                 240 


Leu Ile Lys Asp Ala Ile Val Ser Thr Gln Pro Ala Met Met Val Asn 
                245                 250                 255     


Leu Arg Ala Cys Ser Ala Pro Gly Gly Leu Val Pro Ser Glu Lys Pro 
            260                 265                 270         


Pro Met Met Pro Gln Ala Gln Pro Ala Ile Pro Arg Pro Asn Arg Leu 
        275                 280                 285             


Phe Leu Arg Gln Leu Arg Ala Ser His Leu Gly Asn Glu Leu Glu Gly 
    290                 295                 300                 


Thr Glu Glu Leu Cys Cys Val Ala Glu Leu Asp Asn Pro Met Gln Gln 
305                 310                 315                 320 


Lys Trp Thr Lys Pro Ala Arg Ala Gly Ser Glu Val Glu Trp Thr Glu 
                325                 330                 335     


Asp Leu Ala Leu Asp Leu Gly Pro Gln Ser Arg Glu Leu Thr Leu Lys 
            340                 345                 350         


Val Leu Arg Ser Ser Ser Cys Gly Asp Thr Glu Leu Leu Gly Gln Ala 
        355                 360                 365             


Thr Leu Pro Val Gly Ser Pro Ser Arg Pro Leu Ser Arg Arg Gln Leu 
    370                 375                 380                 


Cys Pro Leu Thr Pro Gly Pro Gly Lys Ala Leu Gly Pro Ala Ala Thr 
385                 390                 395                 400 


Met Ala Val Glu Leu His Tyr Glu Glu Gly Ser Pro Arg Asn Leu Gly 
                405                 410                 415     


Thr Pro Thr Ser Ser Thr Pro Arg Pro Ser Ile Thr Pro Thr Lys Lys 
            420                 425                 430         


Ile Glu Leu Asp Arg Thr Ile Met Pro Asp Gly Thr Ile Val Thr Thr 
        435                 440                 445             


Val Thr Thr Val Gln Ser Arg Pro Arg Ile Asp Gly Lys Leu Asp Ser 
    450                 455                 460                 


Pro Ser Arg Ser Pro Ser Lys Val Glu Val Thr Glu Lys Thr Thr Thr 
465                 470                 475                 480 


Val Leu Ser Glu Ser Ser Gly Pro Ser Asn Thr Ser His Ser Ser Ser 
                485                 490                 495     


Pro Gly Asp Ser His Leu Ser Asn Gly Leu Asp Pro Val Ala Glu Thr 
            500                 505                 510         


Ala Ile Arg Gln Leu Thr Glu Pro Ser Gly Arg Val Ala Lys Lys Thr 
        515                 520                 525             


Pro Thr Lys Arg Ser Thr Leu Ile Ile Ser Gly Val Ser Lys Val Pro 
    530                 535                 540                 


Ile Ala Gln Asp Glu Leu Ala Leu Ser Leu Gly Tyr Ala Ala Ser Leu 
545                 550                 555                 560 


Glu Ala Ser Val Gln Asp Asp Ala Gly Thr Ser Gly Gly Pro Ser Ser 
                565                 570                 575     


Pro Pro Ser Asp Pro Pro Ala Met Ser Pro Gly Pro Leu Asp Ala Leu 
            580                 585                 590         


Ser Ser Pro Thr Ser Val Gln Glu Ala Asp Glu Thr Thr Arg Ser Asp 
        595                 600                 605             


Ile Ser Glu Arg Pro Ser Val Asp Asp Ile Glu Ser Glu Thr Gly Ser 
    610                 615                 620                 


Thr Gly Ala Leu Glu Thr Arg Ser Leu Lys Asp His Lys Val Ser Phe 
625                 630                 635                 640 


Leu Arg Ser Gly Thr Lys Leu Ile Phe Arg Arg Arg Pro Arg Gln Lys 
                645                 650                 655     


Glu Ala Gly Leu Ser Gln Ser His Asp Asp Leu Ser Asn Ala Thr Ala 
            660                 665                 670         


Thr Pro Ser Val Arg Lys Lys Ala Gly Ser Phe Ser Arg Arg Leu Ile 
        675                 680                 685             


Lys Arg Phe Ser Phe Lys Ser Lys Pro Lys Ala Asn Gly Asn Pro Ser 
    690                 695                 700                 


Pro Gln Leu 
705         


<210>  3993
<211>  1072
<212>  PRT
<213>  Homo sapiens

<400>  3993

Met Ala Pro Pro Thr Gly Val Leu Ser Ser Leu Leu Leu Leu Val Thr 
1               5                   10                  15      


Ile Ala Gly Cys Ala Arg Lys Gln Cys Ser Glu Gly Arg Thr Tyr Ser 
            20                  25                  30          


Asn Ala Val Ile Ser Pro Asn Leu Glu Thr Thr Arg Ile Met Arg Val 
        35                  40                  45              


Ser His Thr Phe Pro Val Val Asp Cys Thr Ala Ala Cys Cys Asp Leu 
    50                  55                  60                  


Ser Ser Cys Asp Leu Ala Trp Trp Phe Glu Gly Arg Cys Tyr Leu Val 
65                  70                  75                  80  


Ser Cys Pro His Lys Glu Asn Cys Glu Pro Lys Lys Met Gly Pro Ile 
                85                  90                  95      


Arg Ser Tyr Leu Thr Phe Val Leu Arg Pro Val Gln Arg Pro Ala Gln 
            100                 105                 110         


Leu Leu Asp Tyr Gly Asp Met Met Leu Asn Arg Gly Ser Pro Ser Gly 
        115                 120                 125             


Ile Trp Gly Asp Ser Pro Glu Asp Ile Arg Lys Asp Leu Thr Phe Leu 
    130                 135                 140                 


Gly Lys Asp Trp Gly Leu Glu Glu Met Ser Glu Tyr Ser Asp Asp Tyr 
145                 150                 155                 160 


Arg Glu Leu Glu Lys Asp Leu Leu Gln Pro Ser Gly Lys Gln Glu Pro 
                165                 170                 175     


Arg Gly Ser Ala Glu Tyr Thr Asp Trp Gly Leu Leu Pro Gly Ser Glu 
            180                 185                 190         


Gly Ala Phe Asn Ser Ser Val Gly Asp Ser Pro Ala Val Pro Ala Glu 
        195                 200                 205             


Thr Gln Gln Asp Pro Glu Leu His Tyr Leu Asn Glu Ser Ala Ser Thr 
    210                 215                 220                 


Pro Ala Pro Lys Leu Pro Glu Arg Ser Val Leu Leu Pro Leu Pro Thr 
225                 230                 235                 240 


Thr Pro Ser Ser Gly Glu Val Leu Glu Lys Glu Lys Ala Ser Gln Leu 
                245                 250                 255     


Gln Glu Gln Ser Ser Asn Ser Ser Gly Lys Glu Val Leu Met Pro Ser 
            260                 265                 270         


His Ser Leu Pro Pro Ala Ser Leu Glu Leu Ser Ser Val Thr Val Glu 
        275                 280                 285             


Lys Ser Pro Val Leu Thr Val Thr Pro Gly Ser Thr Glu His Ser Ile 
    290                 295                 300                 


Pro Thr Pro Pro Thr Ser Ala Ala Pro Ser Glu Ser Thr Pro Ser Glu 
305                 310                 315                 320 


Leu Pro Ile Ser Pro Thr Thr Ala Pro Arg Thr Val Lys Glu Leu Thr 
                325                 330                 335     


Val Ser Ala Gly Asp Asn Leu Ile Ile Thr Leu Pro Asp Asn Glu Val 
            340                 345                 350         


Glu Leu Lys Ala Phe Val Ala Pro Ala Pro Pro Val Glu Thr Thr Tyr 
        355                 360                 365             


Asn Tyr Glu Trp Asn Leu Ile Ser His Pro Thr Asp Tyr Gln Gly Glu 
    370                 375                 380                 


Ile Lys Gln Gly His Lys Gln Thr Leu Asn Leu Ser Gln Leu Ser Val 
385                 390                 395                 400 


Gly Leu Tyr Val Phe Lys Val Thr Val Ser Ser Glu Asn Ala Phe Gly 
                405                 410                 415     


Glu Gly Phe Val Asn Val Thr Val Lys Pro Ala Arg Arg Val Asn Leu 
            420                 425                 430         


Pro Pro Val Ala Val Val Ser Pro Gln Leu Gln Glu Leu Thr Leu Pro 
        435                 440                 445             


Leu Thr Ser Ala Leu Ile Asp Gly Ser Gln Ser Thr Asp Asp Thr Glu 
    450                 455                 460                 


Ile Val Ser Tyr His Trp Glu Glu Ile Asn Gly Pro Phe Ile Glu Glu 
465                 470                 475                 480 


Lys Thr Ser Val Asp Ser Pro Val Leu Arg Leu Ser Asn Leu Asp Pro 
                485                 490                 495     


Gly Asn Tyr Ser Phe Arg Leu Thr Val Thr Asp Ser Asp Gly Ala Thr 
            500                 505                 510         


Asn Ser Thr Thr Ala Ala Leu Ile Val Asn Asn Ala Val Asp Tyr Pro 
        515                 520                 525             


Pro Val Ala Asn Ala Gly Pro Asn His Thr Ile Thr Leu Pro Gln Asn 
    530                 535                 540                 


Ser Ile Thr Leu Asn Gly Asn Gln Ser Ser Asp Asp His Gln Ile Val 
545                 550                 555                 560 


Leu Tyr Glu Trp Ser Leu Gly Pro Gly Ser Glu Gly Lys His Val Val 
                565                 570                 575     


Met Gln Gly Val Gln Thr Pro Tyr Leu His Leu Ser Ala Met Gln Glu 
            580                 585                 590         


Gly Asp Tyr Thr Phe Gln Leu Lys Val Thr Asp Ser Ser Arg Gln Gln 
        595                 600                 605             


Ser Thr Ala Val Val Thr Val Ile Val Gln Pro Glu Asn Asn Arg Pro 
    610                 615                 620                 


Pro Val Ala Val Ala Gly Pro Asp Lys Glu Leu Ile Phe Pro Val Glu 
625                 630                 635                 640 


Ser Ala Thr Leu Asp Gly Ser Ser Ser Ser Asp Asp His Gly Ile Val 
                645                 650                 655     


Phe Tyr His Trp Glu His Val Arg Gly Pro Ser Ala Val Glu Met Glu 
            660                 665                 670         


Asn Ile Asp Lys Ala Ile Ala Thr Val Thr Gly Leu Gln Val Gly Thr 
        675                 680                 685             


Tyr His Phe Arg Leu Thr Val Lys Asp Gln Gln Gly Leu Ser Ser Thr 
    690                 695                 700                 


Ser Thr Leu Thr Val Ala Val Lys Lys Glu Asn Asn Ser Pro Pro Arg 
705                 710                 715                 720 


Ala Arg Ala Gly Gly Arg His Val Leu Val Leu Pro Asn Asn Ser Ile 
                725                 730                 735     


Thr Leu Asp Gly Ser Arg Ser Thr Asp Asp Gln Arg Ile Val Ser Tyr 
            740                 745                 750         


Leu Trp Ile Arg Asp Gly Gln Ser Pro Ala Ala Gly Asp Val Ile Asp 
        755                 760                 765             


Gly Ser Asp His Ser Val Ala Leu Gln Leu Thr Asn Leu Val Glu Gly 
    770                 775                 780                 


Val Tyr Thr Phe His Leu Arg Val Thr Asp Ser Gln Gly Ala Ser Asp 
785                 790                 795                 800 


Thr Asp Thr Ala Thr Val Glu Val Gln Pro Asp Pro Arg Lys Ser Gly 
                805                 810                 815     


Leu Val Glu Leu Thr Leu Gln Val Gly Val Gly Gln Leu Thr Glu Gln 
            820                 825                 830         


Arg Lys Asp Thr Leu Val Arg Gln Leu Ala Val Leu Leu Asn Val Leu 
        835                 840                 845             


Asp Ser Asp Ile Lys Val Gln Lys Ile Arg Ala His Ser Asp Leu Ser 
    850                 855                 860                 


Thr Val Ile Val Phe Tyr Val Gln Ser Arg Pro Pro Phe Lys Val Leu 
865                 870                 875                 880 


Lys Ala Ala Glu Val Ala Arg Asn Leu His Met Arg Leu Ser Lys Glu 
                885                 890                 895     


Lys Ala Asp Phe Leu Leu Phe Lys Val Leu Arg Val Asp Thr Ala Gly 
            900                 905                 910         


Cys Leu Leu Lys Cys Ser Gly His Gly His Cys Asp Pro Leu Thr Lys 
        915                 920                 925             


Arg Cys Ile Cys Ser His Leu Trp Met Glu Asn Leu Ile Gln Arg Tyr 
    930                 935                 940                 


Ile Trp Asp Gly Glu Ser Asn Cys Glu Trp Ser Ile Phe Tyr Val Thr 
945                 950                 955                 960 


Val Leu Ala Phe Thr Leu Ile Val Leu Thr Gly Gly Phe Thr Trp Leu 
                965                 970                 975     


Cys Ile Cys Cys Cys Lys Arg Gln Lys Arg Thr Lys Ile Arg Lys Lys 
            980                 985                 990         


Thr Lys Tyr Thr Ile Leu Asp Asn  Met Asp Glu Gln Glu  Arg Met Glu 
        995                 1000                 1005             


Leu Arg  Pro Lys Tyr Gly Ile  Lys His Arg Ser Thr  Glu His Asn 
    1010                 1015                 1020             


Ser Ser  Leu Met Val Ser Glu  Ser Glu Phe Asp Ser  Asp Gln Asp 
    1025                 1030                 1035             


Thr Ile  Phe Ser Arg Glu Lys  Met Glu Arg Gly Asn  Pro Lys Val 
    1040                 1045                 1050             


Ser Met  Asn Gly Ser Ile Arg  Asn Gly Ala Ser Phe  Ser Tyr Cys 
    1055                 1060                 1065             


Ser Lys  Asp Arg 
    1070         


<210>  3994
<211>  811
<212>  PRT
<213>  Homo sapiens

<400>  3994

Met Glu Ala Ala Arg Ala Leu Arg Leu Leu Leu Val Val Cys Gly Cys 
1               5                   10                  15      


Leu Ala Leu Pro Pro Leu Ala Glu Pro Val Cys Pro Glu Arg Cys Asp 
            20                  25                  30          


Cys Gln His Pro Gln His Leu Leu Cys Thr Asn Arg Gly Leu Arg Val 
        35                  40                  45              


Val Pro Lys Thr Ser Ser Leu Pro Ser Pro His Asp Val Leu Thr Tyr 
    50                  55                  60                  


Ser Leu Gly Gly Asn Phe Ile Thr Asn Ile Thr Ala Phe Asp Phe His 
65                  70                  75                  80  


Arg Leu Gly Gln Leu Arg Arg Leu Asp Leu Gln Tyr Asn Gln Ile Arg 
                85                  90                  95      


Ser Leu His Pro Lys Thr Phe Glu Lys Leu Ser Arg Leu Glu Glu Leu 
            100                 105                 110         


Tyr Leu Gly Asn Asn Leu Leu Gln Ala Leu Ala Pro Gly Thr Leu Ala 
        115                 120                 125             


Pro Leu Arg Lys Leu Arg Ile Leu Tyr Ala Asn Gly Asn Glu Ile Ser 
    130                 135                 140                 


Arg Leu Ser Arg Gly Ser Phe Glu Gly Leu Glu Ser Leu Val Lys Leu 
145                 150                 155                 160 


Arg Leu Asp Gly Asn Ala Leu Gly Ala Leu Pro Asp Ala Val Phe Ala 
                165                 170                 175     


Pro Leu Gly Asn Leu Leu Tyr Leu His Leu Glu Ser Asn Arg Ile Arg 
            180                 185                 190         


Phe Leu Gly Lys Asn Ala Phe Ala Gln Leu Gly Lys Leu Arg Phe Leu 
        195                 200                 205             


Asn Leu Ser Ala Asn Glu Leu Gln Pro Ser Leu Arg His Ala Ala Thr 
    210                 215                 220                 


Phe Ala Pro Leu Arg Ser Leu Ser Ser Leu Ile Leu Ser Ala Asn Asn 
225                 230                 235                 240 


Leu Gln His Leu Gly Pro Arg Ile Phe Gln His Leu Pro Arg Leu Gly 
                245                 250                 255     


Leu Leu Ser Leu Arg Gly Asn Gln Leu Thr His Leu Ala Pro Glu Ala 
            260                 265                 270         


Phe Trp Gly Leu Glu Ala Leu Arg Glu Leu Arg Leu Glu Gly Asn Arg 
        275                 280                 285             


Leu Ser Gln Leu Pro Thr Ala Leu Leu Glu Pro Leu His Ser Leu Glu 
    290                 295                 300                 


Ala Leu Asp Leu Ser Gly Asn Glu Leu Ser Ala Leu His Pro Ala Thr 
305                 310                 315                 320 


Phe Gly His Leu Gly Arg Leu Arg Glu Leu Ser Leu Arg Asn Asn Ala 
                325                 330                 335     


Leu Ser Ala Leu Ser Gly Asp Ile Phe Ala Ala Ser Pro Ala Leu Tyr 
            340                 345                 350         


Arg Leu Asp Leu Asp Gly Asn Gly Trp Thr Cys Asp Cys Arg Leu Arg 
        355                 360                 365             


Gly Leu Lys Arg Trp Met Gly Asp Trp His Ser Gln Gly Arg Leu Leu 
    370                 375                 380                 


Thr Val Phe Val Gln Cys Arg His Pro Pro Ala Leu Arg Gly Lys Tyr 
385                 390                 395                 400 


Leu Asp Tyr Leu Asp Asp Gln Gln Leu Gln Asn Gly Ser Cys Ala Asp 
                405                 410                 415     


Pro Ser Pro Ser Ala Ser Leu Thr Ala Asp Arg Arg Arg Gln Pro Leu 
            420                 425                 430         


Pro Thr Ala Ala Gly Glu Glu Met Thr Pro Pro Ala Gly Leu Ala Glu 
        435                 440                 445             


Glu Leu Pro Pro Gln Pro Gln Leu Gln Gln Gln Gly Arg Phe Leu Ala 
    450                 455                 460                 


Gly Val Ala Trp Asp Gly Ala Ala Arg Glu Leu Val Gly Asn Arg Ser 
465                 470                 475                 480 


Ala Leu Arg Leu Ser Arg Arg Gly Pro Gly Leu Gln Gln Pro Ser Pro 
                485                 490                 495     


Ser Val Ala Ala Ala Ala Gly Pro Ala Pro Gln Ser Leu Asp Leu His 
            500                 505                 510         


Lys Lys Pro Gln Arg Gly Arg Pro Thr Arg Ala Asp Pro Ala Leu Ala 
        515                 520                 525             


Glu Pro Thr Pro Thr Ala Ser Pro Gly Ser Ala Pro Ser Pro Ala Gly 
    530                 535                 540                 


Asp Pro Trp Gln Arg Ala Thr Lys His Arg Leu Gly Thr Glu His Gln 
545                 550                 555                 560 


Glu Arg Ala Ala Gln Ser Asp Gly Gly Ala Gly Leu Pro Pro Leu Val 
                565                 570                 575     


Ser Asp Pro Cys Asp Phe Asn Lys Phe Ile Leu Cys Asn Leu Thr Val 
            580                 585                 590         


Glu Ala Val Gly Ala Asp Ser Ala Ser Val Arg Trp Ala Val Arg Glu 
        595                 600                 605             


His Arg Ser Pro Arg Pro Leu Gly Gly Ala Arg Phe Arg Leu Leu Phe 
    610                 615                 620                 


Asp Arg Phe Gly Gln Gln Pro Lys Phe His Arg Phe Val Tyr Leu Pro 
625                 630                 635                 640 


Glu Ser Ser Asp Ser Ala Thr Leu Arg Glu Leu Arg Gly Asp Thr Pro 
                645                 650                 655     


Tyr Leu Val Cys Val Glu Gly Val Leu Gly Gly Arg Val Cys Pro Val 
            660                 665                 670         


Ala Pro Arg Asp His Cys Ala Gly Leu Val Thr Leu Pro Glu Ala Gly 
        675                 680                 685             


Ser Arg Gly Gly Val Asp Tyr Gln Leu Leu Thr Leu Ala Leu Leu Thr 
    690                 695                 700                 


Val Asn Ala Leu Leu Val Leu Leu Ala Leu Ala Ala Trp Ala Ser Arg 
705                 710                 715                 720 


Trp Leu Arg Arg Lys Leu Arg Ala Arg Arg Lys Gly Gly Ala Pro Val 
                725                 730                 735     


His Val Arg His Met Tyr Ser Thr Arg Arg Pro Leu Arg Ser Met Gly 
            740                 745                 750         


Thr Gly Val Ser Ala Asp Phe Ser Gly Phe Gln Ser His Arg Pro Arg 
        755                 760                 765             


Thr Thr Val Cys Ala Leu Ser Glu Ala Asp Leu Ile Glu Phe Pro Cys 
    770                 775                 780                 


Asp Arg Phe Met Asp Ser Ala Gly Gly Gly Ala Gly Gly Ser Leu Arg 
785                 790                 795                 800 


Arg Glu Asp Arg Leu Leu Gln Arg Phe Ala Asp 
                805                 810     


<210>  3995
<211>  608
<212>  PRT
<213>  Homo sapiens

<400>  3995

Met Ala Ala Ser Lys Pro Val Glu Ala Ala Val Val Ala Ala Ala Val 
1               5                   10                  15      


Pro Ser Ser Gly Ser Gly Val Gly Gly Gly Gly Thr Ala Gly Pro Gly 
            20                  25                  30          


Thr Gly Gly Leu Pro Arg Trp Gln Leu Ala Leu Ala Val Gly Ala Pro 
        35                  40                  45              


Leu Leu Leu Gly Ala Gly Ala Ile Tyr Leu Trp Ser Arg Gln Gln Arg 
    50                  55                  60                  


Arg Arg Glu Ala Arg Gly Arg Gly Asp Ala Ser Gly Leu Lys Arg Asn 
65                  70                  75                  80  


Ser Glu Arg Lys Thr Pro Glu Gly Arg Ala Ser Pro Ala Pro Gly Ser 
                85                  90                  95      


Gly His Pro Glu Gly Pro Gly Ala His Leu Asp Met Asn Ser Leu Asp 
            100                 105                 110         


Arg Ala Gln Ala Ala Lys Asn Lys Gly Asn Lys Tyr Phe Lys Ala Gly 
        115                 120                 125             


Lys Tyr Glu Gln Ala Ile Gln Cys Tyr Thr Glu Ala Ile Ser Leu Cys 
    130                 135                 140                 


Pro Thr Glu Lys Asn Val Asp Leu Ser Thr Phe Tyr Gln Asn Arg Ala 
145                 150                 155                 160 


Ala Ala Phe Glu Gln Leu Gln Lys Trp Lys Glu Val Ala Gln Asp Cys 
                165                 170                 175     


Thr Lys Ala Val Glu Leu Asn Pro Lys Tyr Val Lys Ala Leu Phe Arg 
            180                 185                 190         


Arg Ala Lys Ala His Glu Lys Leu Asp Asn Lys Lys Glu Cys Leu Glu 
        195                 200                 205             


Asp Val Thr Ala Val Cys Ile Leu Glu Gly Phe Gln Asn Gln Gln Ser 
    210                 215                 220                 


Met Leu Leu Ala Asp Lys Val Leu Lys Leu Leu Gly Lys Glu Lys Ala 
225                 230                 235                 240 


Lys Glu Lys Tyr Lys Asn Arg Glu Pro Leu Met Pro Ser Pro Gln Phe 
                245                 250                 255     


Ile Lys Ser Tyr Phe Ser Ser Phe Thr Asp Asp Ile Ile Ser Gln Pro 
            260                 265                 270         


Met Leu Lys Gly Glu Lys Ser Asp Glu Asp Lys Asp Lys Glu Gly Glu 
        275                 280                 285             


Ala Leu Glu Val Lys Glu Asn Ser Gly Tyr Leu Lys Ala Lys Gln Tyr 
    290                 295                 300                 


Met Glu Glu Glu Asn Tyr Asp Lys Ile Ile Ser Glu Cys Ser Lys Glu 
305                 310                 315                 320 


Ile Asp Ala Glu Gly Lys Tyr Met Ala Glu Ala Leu Leu Leu Arg Ala 
                325                 330                 335     


Thr Phe Tyr Leu Leu Ile Gly Asn Ala Asn Ala Ala Lys Pro Asp Leu 
            340                 345                 350         


Asp Lys Val Ile Ser Leu Lys Glu Ala Asn Val Lys Leu Arg Ala Asn 
        355                 360                 365             


Ala Leu Ile Lys Arg Gly Ser Met Tyr Met Gln Gln Gln Gln Pro Leu 
    370                 375                 380                 


Leu Ser Thr Gln Asp Phe Asn Met Ala Ala Asp Ile Asp Pro Gln Asn 
385                 390                 395                 400 


Ala Asp Val Tyr His His Arg Gly Gln Leu Lys Ile Leu Leu Asp Gln 
                405                 410                 415     


Val Glu Glu Ala Val Ala Asp Phe Asp Glu Cys Ile Arg Leu Arg Pro 
            420                 425                 430         


Glu Ser Ala Leu Ala Gln Ala Gln Lys Cys Phe Ala Leu Tyr Arg Gln 
        435                 440                 445             


Ala Tyr Thr Gly Asn Asn Ser Ser Gln Ile Gln Ala Ala Met Lys Gly 
    450                 455                 460                 


Phe Glu Glu Val Ile Lys Lys Phe Pro Arg Cys Ala Glu Gly Tyr Ala 
465                 470                 475                 480 


Leu Tyr Ala Gln Ala Leu Thr Asp Gln Gln Gln Phe Gly Lys Ala Asp 
                485                 490                 495     


Glu Met Tyr Asp Lys Cys Ile Asp Leu Glu Pro Asp Asn Ala Thr Thr 
            500                 505                 510         


Tyr Val His Lys Gly Leu Leu Gln Leu Gln Trp Lys Gln Asp Leu Asp 
        515                 520                 525             


Arg Gly Leu Glu Leu Ile Ser Lys Ala Ile Glu Ile Asp Asn Lys Cys 
    530                 535                 540                 


Asp Phe Ala Tyr Glu Thr Met Gly Thr Ile Glu Val Gln Arg Gly Asn 
545                 550                 555                 560 


Met Glu Lys Ala Ile Asp Met Phe Asn Lys Ala Ile Asn Leu Ala Lys 
                565                 570                 575     


Ser Glu Met Glu Met Ala His Leu Tyr Ser Leu Cys Asp Ala Ala His 
            580                 585                 590         


Ala Gln Thr Glu Val Ala Lys Lys Tyr Gly Leu Lys Pro Pro Thr Leu 
        595                 600                 605             


<210>  3996
<211>  763
<212>  PRT
<213>  Homo sapiens

<400>  3996

Met Gln Arg Ala Gly Ser Ser Gly Gly Arg Gly Glu Cys Asp Ile Ser 
1               5                   10                  15      


Gly Ala Gly Arg Leu Gly Leu Glu Glu Ala Ala Arg Leu Ser Cys Ala 
            20                  25                  30          


Val His Thr Ser Pro Gly Gly Gly Arg Arg Pro Gly Gln Ala Ala Gly 
        35                  40                  45              


Met Ser Ala Lys Glu Arg Pro Lys Gly Lys Val Ile Lys Asp Ser Val 
    50                  55                  60                  


Thr Leu Leu Pro Cys Phe Tyr Phe Val Glu Leu Pro Ile Leu Ala Ser 
65                  70                  75                  80  


Ser Val Val Ser Leu Tyr Phe Leu Glu Leu Thr Asp Val Phe Lys Pro 
                85                  90                  95      


Val His Ser Gly Phe Ser Cys Tyr Asp Arg Ser Leu Ser Met Pro Tyr 
            100                 105                 110         


Ile Glu Pro Thr Gln Glu Ala Ile Pro Phe Leu Met Leu Leu Ser Leu 
        115                 120                 125             


Ala Phe Ala Gly Pro Ala Ile Thr Ile Met Val Gly Glu Gly Ile Leu 
    130                 135                 140                 


Tyr Cys Cys Leu Ser Lys Arg Arg Asn Gly Val Gly Leu Glu Pro Asn 
145                 150                 155                 160 


Ile Asn Ala Gly Gly Cys Asn Phe Asn Ser Phe Leu Arg Arg Ala Val 
                165                 170                 175     


Arg Phe Val Gly Val His Val Phe Gly Leu Cys Ser Thr Ala Leu Ile 
            180                 185                 190         


Thr Asp Ile Ile Gln Leu Ser Thr Gly Tyr Gln Ala Pro Tyr Phe Leu 
        195                 200                 205             


Thr Val Cys Lys Pro Asn Tyr Thr Ser Leu Asn Val Ser Cys Lys Glu 
    210                 215                 220                 


Asn Ser Tyr Ile Val Glu Asp Ile Cys Ser Gly Ser Asp Leu Thr Val 
225                 230                 235                 240 


Ile Asn Ser Gly Arg Lys Ser Phe Pro Ser Gln His Ala Thr Leu Ala 
                245                 250                 255     


Ala Phe Ala Ala Val Tyr Val Ser Met Tyr Phe Asn Ser Thr Leu Thr 
            260                 265                 270         


Asp Ser Ser Lys Leu Leu Lys Pro Leu Leu Val Phe Thr Phe Ile Ile 
        275                 280                 285             


Cys Gly Ile Ile Cys Gly Leu Thr Arg Ile Thr Gln Tyr Lys Asn His 
    290                 295                 300                 


Pro Val Asp Val Tyr Cys Gly Phe Leu Ile Gly Gly Gly Ile Ala Leu 
305                 310                 315                 320 


Tyr Leu Gly Leu Tyr Ala Val Gly Asn Phe Leu Pro Ser Asp Glu Ser 
                325                 330                 335     


Met Phe Gln His Arg Asp Ala Leu Arg Ser Leu Thr Asp Leu Asn Gln 
            340                 345                 350         


Asp Pro Asn Arg Leu Leu Ser Ala Lys Asn Gly Ser Ser Ser Asp Gly 
        355                 360                 365             


Ile Ala His Thr Glu Gly Ile Leu Asn Arg Asn His Arg Asp Ala Ser 
    370                 375                 380                 


Ser Leu Thr Asn Leu Lys Arg Ala Asn Ala Asp Val Glu Ile Ile Thr 
385                 390                 395                 400 


Pro Arg Ser Pro Met Gly Lys Glu Asn Met Val Thr Phe Ser Asn Thr 
                405                 410                 415     


Leu Pro Arg Ala Asn Thr Pro Ser Val Glu Asp Pro Val Arg Arg Asn 
            420                 425                 430         


Ala Ser Ile His Ala Ser Met Asp Ser Ala Arg Ser Lys Gln Leu Leu 
        435                 440                 445             


Thr Gln Trp Lys Asn Lys Asn Glu Ser Arg Lys Leu Ser Leu Gln Val 
    450                 455                 460                 


Ile Glu Pro Glu Pro Gly Gln Ser Pro Pro Arg Ser Ile Glu Met Arg 
465                 470                 475                 480 


Ser Ser Ser Glu Pro Ser Arg Val Gly Val Asn Gly Asp His His Gly 
                485                 490                 495     


Pro Gly Asn Gln Tyr Leu Lys Ile Gln Pro Gly Ala Val Pro Gly Cys 
            500                 505                 510         


Asn Asn Ser Met Pro Gly Gly Pro Arg Val Ser Ile Gln Ser Arg Pro 
        515                 520                 525             


Gly Ser Ser Gln Leu Val His Ile Pro Glu Glu Thr Gln Glu Asn Ile 
    530                 535                 540                 


Ser Thr Ser Pro Lys Ser Ser Ser Ala Arg Ala Lys Trp Leu Lys Ala 
545                 550                 555                 560 


Ala Glu Lys Thr Val Ala Cys Asn Arg Ser Asn Ser Gln Pro Arg Ile 
                565                 570                 575     


Met Gln Val Ile Ala Met Ser Lys Gln Gln Gly Val Leu Gln Ser Ser 
            580                 585                 590         


Pro Lys Asn Thr Glu Gly Ser Thr Val Ser Cys Thr Gly Ser Ile Arg 
        595                 600                 605             


Tyr Lys Thr Leu Thr Asp His Glu Pro Ser Gly Ile Val Arg Val Glu 
    610                 615                 620                 


Ala His Pro Glu Asn Asn Arg Pro Ile Ile Gln Ile Pro Ser Thr Glu 
625                 630                 635                 640 


Gly Glu Gly Ser Gly Ser Trp Lys Trp Lys Ala Pro Glu Lys Gly Ser 
                645                 650                 655     


Leu Arg Gln Thr Tyr Glu Leu Asn Asp Leu Asn Arg Asp Ser Glu Ser 
            660                 665                 670         


Cys Glu Ser Leu Lys Asp Ser Phe Gly Ser Gly Asp Arg Lys Arg Ser 
        675                 680                 685             


Asn Ile Asp Ser Asn Glu His His His His Gly Ile Thr Thr Ile Arg 
    690                 695                 700                 


Val Thr Pro Val Glu Gly Ser Glu Ile Gly Ser Glu Thr Leu Ser Ile 
705                 710                 715                 720 


Ser Ser Ser Arg Asp Ser Thr Leu Arg Arg Lys Gly Asn Ile Ile Leu 
                725                 730                 735     


Ile Pro Glu Arg Ser Asn Ser Pro Glu Asn Thr Arg Asn Ile Phe Tyr 
            740                 745                 750         


Lys Gly Thr Ser Pro Thr Arg Ala Tyr Lys Asp 
        755                 760             


<210>  3997
<211>  907
<212>  PRT
<213>  Homo sapiens

<400>  3997

Met Pro Thr Ala Ala Ala Pro Ile Ile Ser Ser Val Gln Lys Leu Val 
1               5                   10                  15      


Leu Tyr Glu Thr Arg Ala Arg Tyr Phe Leu Val Gly Ser Asn Asn Ala 
            20                  25                  30          


Glu Thr Lys Tyr Arg Val Leu Lys Ile Asp Arg Thr Glu Pro Lys Asp 
        35                  40                  45              


Leu Val Ile Ile Asp Asp Arg His Val Tyr Thr Gln Gln Glu Val Arg 
    50                  55                  60                  


Glu Leu Leu Gly Arg Leu Asp Leu Gly Asn Arg Thr Lys Met Gly Gln 
65                  70                  75                  80  


Lys Gly Ser Ser Gly Leu Phe Arg Ala Val Ser Ala Phe Gly Val Val 
                85                  90                  95      


Gly Phe Val Arg Phe Leu Glu Gly Tyr Tyr Ile Val Leu Ile Thr Lys 
            100                 105                 110         


Arg Arg Lys Met Ala Asp Ile Gly Gly His Ala Ile Tyr Lys Val Glu 
        115                 120                 125             


Asp Thr Asn Met Ile Tyr Ile Pro Asn Asp Ser Val Arg Val Thr His 
    130                 135                 140                 


Pro Asp Glu Ala Arg Tyr Leu Arg Ile Phe Gln Asn Val Asp Leu Ser 
145                 150                 155                 160 


Ser Asn Phe Tyr Phe Ser Tyr Ser Tyr Asp Leu Ser His Ser Leu Gln 
                165                 170                 175     


Tyr Asn Leu Thr Val Leu Arg Met Pro Leu Glu Met Leu Lys Ser Glu 
            180                 185                 190         


Met Thr Gln Asn Arg Gln Glu Ser Phe Asp Ile Phe Glu Asp Glu Gly 
        195                 200                 205             


Leu Ile Thr Gln Gly Gly Ser Gly Val Phe Gly Ile Cys Ser Glu Pro 
    210                 215                 220                 


Tyr Met Lys Tyr Val Trp Asn Gly Glu Leu Leu Asp Ile Ile Lys Ser 
225                 230                 235                 240 


Thr Val His Arg Asp Trp Leu Leu Tyr Ile Ile His Gly Phe Cys Gly 
                245                 250                 255     


Gln Ser Lys Leu Leu Ile Tyr Gly Arg Pro Val Tyr Val Thr Leu Ile 
            260                 265                 270         


Ala Arg Arg Ser Ser Lys Phe Ala Gly Thr Arg Phe Leu Lys Arg Gly 
        275                 280                 285             


Ala Asn Cys Glu Gly Asp Val Ala Asn Glu Val Glu Thr Glu Gln Ile 
    290                 295                 300                 


Leu Cys Asp Ala Ser Val Met Ser Phe Thr Ala Gly Ser Tyr Ser Ser 
305                 310                 315                 320 


Tyr Val Gln Val Arg Gly Ser Val Pro Leu Tyr Trp Ser Gln Asp Ile 
                325                 330                 335     


Ser Thr Met Met Pro Lys Pro Pro Ile Thr Leu Asp Gln Ala Asp Pro 
            340                 345                 350         


Phe Ala His Val Ala Ala Leu His Phe Asp Gln Met Phe Gln Arg Phe 
        355                 360                 365             


Gly Ser Pro Ile Ile Ile Leu Asn Leu Val Lys Glu Arg Glu Lys Arg 
    370                 375                 380                 


Lys His Glu Arg Ile Leu Ser Glu Glu Leu Val Ala Ala Val Thr Tyr 
385                 390                 395                 400 


Leu Asn Gln Phe Leu Pro Pro Glu His Thr Ile Val Tyr Ile Pro Trp 
                405                 410                 415     


Asp Met Ala Lys Tyr Thr Lys Ser Lys Leu Cys Asn Val Leu Asp Arg 
            420                 425                 430         


Leu Asn Val Ile Ala Glu Ser Val Val Lys Lys Thr Gly Phe Phe Val 
        435                 440                 445             


Asn Arg Pro Asp Ser Tyr Cys Ser Ile Leu Arg Pro Asp Glu Lys Trp 
    450                 455                 460                 


Asn Glu Leu Gly Gly Cys Val Ile Pro Thr Gly Arg Leu Gln Thr Gly 
465                 470                 475                 480 


Ile Leu Arg Thr Asn Cys Val Asp Cys Leu Asp Arg Thr Asn Thr Ala 
                485                 490                 495     


Gln Phe Met Val Gly Lys Cys Ala Leu Ala Tyr Gln Leu Tyr Ser Leu 
            500                 505                 510         


Gly Leu Ile Asp Lys Pro Asn Leu Gln Phe Asp Thr Asp Ala Val Arg 
        515                 520                 525             


Leu Phe Glu Glu Leu Tyr Glu Asp His Gly Asp Thr Leu Ser Leu Gln 
    530                 535                 540                 


Tyr Gly Gly Ser Gln Leu Val His Arg Val Lys Thr Tyr Arg Lys Ile 
545                 550                 555                 560 


Ala Pro Trp Thr Gln His Ser Lys Asp Ile Met Gln Thr Leu Ser Arg 
                565                 570                 575     


Tyr Tyr Ser Asn Ala Phe Ser Asp Ala Asp Arg Gln Asp Ser Ile Asn 
            580                 585                 590         


Leu Phe Leu Gly Val Phe His Pro Thr Glu Gly Lys Pro His Leu Trp 
        595                 600                 605             


Glu Leu Pro Thr Asp Phe Tyr Leu His His Lys Asn Thr Met Arg Leu 
    610                 615                 620                 


Leu Pro Thr Arg Arg Ser Tyr Thr Tyr Trp Trp Thr Pro Glu Val Ile 
625                 630                 635                 640 


Lys His Leu Pro Leu Pro Tyr Asp Glu Val Ile Cys Ala Val Asn Leu 
                645                 650                 655     


Lys Lys Leu Ile Val Lys Lys Phe His Lys Tyr Glu Glu Glu Ile Asp 
            660                 665                 670         


Ile His Asn Glu Phe Phe Arg Pro Tyr Glu Leu Ser Ser Phe Asp Asp 
        675                 680                 685             


Thr Phe Cys Leu Ala Met Thr Ser Ser Ala Arg Asp Phe Met Pro Lys 
    690                 695                 700                 


Thr Val Gly Ile Asp Pro Ser Pro Phe Thr Val Arg Lys Pro Asp Glu 
705                 710                 715                 720 


Thr Gly Lys Ser Val Leu Gly Asn Lys Ser Asn Arg Glu Glu Ala Val 
                725                 730                 735     


Leu Gln Arg Lys Thr Ala Ala Ser Ala Pro Pro Pro Pro Ser Glu Glu 
            740                 745                 750         


Ala Val Ser Ser Ser Ser Glu Asp Asp Ser Gly Thr Asp Arg Glu Glu 
        755                 760                 765             


Glu Gly Ser Val Ser Gln Arg Ser Thr Pro Val Lys Met Thr Asp Ala 
    770                 775                 780                 


Gly Asp Ser Ala Lys Val Thr Glu Asn Val Val Gln Pro Met Lys Glu 
785                 790                 795                 800 


Leu Tyr Gly Ile Asn Leu Ser Asp Gly Leu Ser Glu Glu Asp Phe Ser 
                805                 810                 815     


Ile Tyr Ser Arg Phe Val Gln Leu Gly Gln Ser Gln His Lys Gln Asp 
            820                 825                 830         


Lys Asn Ser Gln Gln Pro Cys Ser Arg Cys Ser Asp Gly Val Ile Lys 
        835                 840                 845             


Leu Thr Pro Ile Ser Ala Phe Ser Gln Asp Asn Ile Tyr Glu Val Gln 
    850                 855                 860                 


Pro Pro Arg Val Asp Arg Lys Ser Thr Glu Ile Phe Gln Ala His Ile 
865                 870                 875                 880 


Gln Ala Ser Gln Gly Ile Met Gln Pro Leu Gly Lys Glu Asp Ser Ser 
                885                 890                 895     


Met Tyr Arg Glu Tyr Ile Arg Asn Arg Tyr Leu 
            900                 905         


<210>  3998
<211>  683
<212>  PRT
<213>  Homo sapiens

<400>  3998

Met Asp Asp Tyr Lys Tyr Gln Asp Asn Tyr Gly Gly Tyr Ala Pro Ser 
1               5                   10                  15      


Asp Gly Tyr Tyr Arg Gly Asn Glu Ser Asn Pro Glu Glu Asp Ala Gln 
            20                  25                  30          


Ser Asp Val Thr Glu Gly His Asp Glu Glu Asp Glu Ile Tyr Glu Gly 
        35                  40                  45              


Glu Tyr Gln Gly Ile Pro His Pro Asp Asp Val Lys Ala Lys Gln Ala 
    50                  55                  60                  


Lys Met Ala Pro Ser Arg Met Asp Ser Leu Arg Gly Gln Thr Asp Leu 
65                  70                  75                  80  


Met Ala Glu Arg Leu Glu Asp Glu Glu Gln Leu Ala His Gln Tyr Glu 
                85                  90                  95      


Thr Ile Met Asp Glu Cys Gly His Gly Arg Phe Gln Trp Ile Leu Phe 
            100                 105                 110         


Phe Val Leu Gly Leu Ala Leu Met Ala Asp Gly Val Glu Val Phe Val 
        115                 120                 125             


Val Ser Phe Ala Leu Pro Ser Ala Glu Lys Asp Met Cys Leu Ser Ser 
    130                 135                 140                 


Ser Lys Lys Gly Met Leu Gly Met Ile Val Tyr Leu Gly Met Met Ala 
145                 150                 155                 160 


Gly Ala Phe Ile Leu Gly Gly Leu Ala Asp Lys Leu Gly Arg Lys Arg 
                165                 170                 175     


Val Leu Ser Met Ser Leu Ala Val Asn Ala Ser Phe Ala Ser Leu Ser 
            180                 185                 190         


Ser Phe Val Gln Gly Tyr Gly Ala Phe Leu Phe Cys Arg Leu Ile Ser 
        195                 200                 205             


Gly Ile Gly Ile Gly Gly Ala Leu Pro Ile Val Phe Ala Tyr Phe Ser 
    210                 215                 220                 


Glu Phe Leu Ser Arg Glu Lys Arg Gly Glu His Leu Ser Trp Leu Gly 
225                 230                 235                 240 


Ile Phe Trp Met Thr Gly Gly Leu Tyr Ala Ser Ala Met Ala Trp Ser 
                245                 250                 255     


Ile Ile Pro His Tyr Gly Trp Gly Phe Ser Met Gly Thr Asn Tyr His 
            260                 265                 270         


Phe His Ser Trp Arg Val Phe Val Ile Val Cys Ala Leu Pro Cys Thr 
        275                 280                 285             


Val Ser Met Val Ala Leu Lys Phe Met Pro Glu Ser Pro Arg Phe Leu 
    290                 295                 300                 


Leu Glu Met Gly Lys His Asp Glu Ala Trp Met Ile Leu Lys Gln Val 
305                 310                 315                 320 


His Asp Thr Asn Met Arg Ala Lys Gly Thr Pro Glu Lys Val Phe Thr 
                325                 330                 335     


Val Ser Asn Ile Lys Thr Pro Lys Gln Met Asp Glu Phe Ile Glu Ile 
            340                 345                 350         


Gln Ser Ser Thr Gly Thr Trp Tyr Gln Arg Trp Leu Val Arg Phe Lys 
        355                 360                 365             


Thr Ile Phe Lys Gln Val Trp Asp Asn Ala Leu Tyr Cys Val Met Gly 
    370                 375                 380                 


Pro Tyr Arg Met Asn Thr Leu Ile Leu Ala Val Val Trp Phe Ala Met 
385                 390                 395                 400 


Ala Phe Ser Tyr Tyr Gly Leu Thr Val Trp Phe Pro Asp Met Ile Arg 
                405                 410                 415     


Tyr Phe Gln Asp Glu Glu Tyr Lys Ser Lys Met Lys Val Phe Phe Gly 
            420                 425                 430         


Glu His Val Tyr Gly Ala Thr Ile Asn Phe Thr Met Glu Asn Gln Ile 
        435                 440                 445             


His Gln His Gly Lys Leu Val Asn Asp Lys Phe Thr Arg Met Tyr Phe 
    450                 455                 460                 


Lys His Val Leu Phe Glu Asp Thr Phe Phe Asp Glu Cys Tyr Phe Glu 
465                 470                 475                 480 


Asp Val Thr Ser Thr Asp Thr Tyr Phe Lys Asn Cys Thr Ile Glu Ser 
                485                 490                 495     


Thr Ile Phe Tyr Asn Thr Asp Leu Tyr Glu His Lys Phe Ile Asn Cys 
            500                 505                 510         


Arg Phe Ile Asn Ser Thr Phe Leu Glu Gln Lys Glu Gly Cys His Met 
        515                 520                 525             


Asp Leu Glu Gln Asp Asn Asp Phe Leu Ile Tyr Leu Val Ser Phe Leu 
    530                 535                 540                 


Gly Ser Leu Ser Val Leu Pro Gly Asn Ile Ile Ser Ala Leu Leu Met 
545                 550                 555                 560 


Asp Arg Ile Gly Arg Leu Lys Met Ile Gly Gly Ser Met Leu Ile Ser 
                565                 570                 575     


Ala Val Cys Cys Phe Phe Leu Phe Phe Gly Asn Ser Glu Ser Ala Met 
            580                 585                 590         


Ile Gly Trp Gln Cys Leu Phe Cys Gly Thr Ser Ile Ala Ala Trp Asn 
        595                 600                 605             


Ala Leu Asp Val Ile Thr Val Glu Leu Tyr Pro Thr Asn Gln Arg Ala 
    610                 615                 620                 


Thr Ala Phe Gly Ile Leu Asn Gly Leu Cys Lys Phe Gly Ala Ile Leu 
625                 630                 635                 640 


Gly Asn Thr Ile Phe Ala Ser Phe Val Gly Ile Thr Lys Val Val Pro 
                645                 650                 655     


Ile Leu Leu Ala Ala Ala Ser Leu Val Gly Gly Gly Leu Ile Ala Leu 
            660                 665                 670         


Arg Leu Pro Glu Thr Arg Glu Gln Val Leu Met 
        675                 680             


<210>  3999
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  3999

Met Glu Glu Gly Phe Arg Asp Arg Ala Ala Phe Ile Arg Gly Ala Lys 
1               5                   10                  15      


Asp Ile Ala Lys Glu Val Lys Lys His Ala Ala Lys Lys Val Val Lys 
            20                  25                  30          


Gly Leu Asp Arg Val Gln Asp Glu Tyr Ser Arg Arg Ser Tyr Ser Arg 
        35                  40                  45              


Phe Glu Glu Glu Asp Asp Asp Asp Asp Phe Pro Ala Pro Ser Asp Gly 
    50                  55                  60                  


Tyr Tyr Arg Gly Glu Gly Thr Gln Asp Glu Glu Glu Gly Gly Ala Ser 
65                  70                  75                  80  


Ser Asp Ala Thr Glu Gly His Asp Glu Asp Asp Glu Ile Tyr Glu Gly 
                85                  90                  95      


Glu Tyr Gln Gly Ile Pro Arg Ala Glu Ser Gly Gly Lys Gly Glu Arg 
            100                 105                 110         


Met Ala Asp Gly Ala Pro Leu Ala Gly Val Arg Gly Gly Leu Ser Asp 
        115                 120                 125             


Gly Glu Gly Pro Pro Gly Gly Arg Gly Glu Ala Gln Arg Arg Lys Glu 
    130                 135                 140                 


Arg Glu Glu Leu Ala Gln Gln Tyr Glu Ala Ile Leu Arg Glu Cys Gly 
145                 150                 155                 160 


His Gly Arg Phe Gln Trp Thr Leu Tyr Phe Val Leu Gly Leu Ala Leu 
                165                 170                 175     


Met Ala Asp Gly Val Glu Val Phe Val Val Gly Phe Val Leu Pro Ser 
            180                 185                 190         


Ala Glu Lys Asp Met Cys Leu Ser Asp Ser Asn Lys Gly Met Leu Gly 
        195                 200                 205             


Leu Ile Val Tyr Leu Gly Met Met Val Gly Ala Phe Leu Trp Gly Gly 
    210                 215                 220                 


Leu Ala Asp Arg Leu Gly Arg Arg Gln Cys Leu Leu Ile Ser Leu Ser 
225                 230                 235                 240 


Val Asn Ser Val Phe Ala Phe Phe Ser Ser Phe Val Gln Gly Tyr Gly 
                245                 250                 255     


Thr Phe Leu Phe Cys Arg Leu Leu Ser Gly Val Gly Ile Gly Gly Ser 
            260                 265                 270         


Ile Pro Ile Val Phe Ser Tyr Phe Ser Glu Phe Leu Ala Gln Glu Lys 
        275                 280                 285             


Arg Gly Glu His Leu Ser Trp Leu Cys Met Phe Trp Met Ile Gly Gly 
    290                 295                 300                 


Val Tyr Ala Ala Ala Met Ala Trp Ala Ile Ile Pro His Tyr Gly Trp 
305                 310                 315                 320 


Ser Phe Gln Met Gly Ser Ala Tyr Gln Phe His Ser Trp Arg Val Phe 
                325                 330                 335     


Val Leu Val Cys Ala Phe Pro Ser Val Phe Ala Ile Gly Ala Leu Thr 
            340                 345                 350         


Thr Gln Pro Glu Ser Pro Arg Phe Phe Leu Glu Asn Gly Lys His Asp 
        355                 360                 365             


Glu Ala Trp Met Val Leu Lys Gln Val His Asp Thr Asn Met Arg Ala 
    370                 375                 380                 


Lys Gly His Pro Glu Arg Val Phe Ser Val Thr His Ile Lys Thr Ile 
385                 390                 395                 400 


His Gln Glu Asp Glu Leu Ile Glu Ile Gln Ser Asp Thr Gly Thr Trp 
                405                 410                 415     


Tyr Gln Arg Trp Gly Val Arg Ala Leu Ser Leu Gly Gly Gln Val Trp 
            420                 425                 430         


Gly Asn Phe Leu Ser Cys Phe Gly Pro Glu Tyr Arg Arg Ile Thr Leu 
        435                 440                 445             


Met Met Met Gly Val Trp Phe Thr Met Ser Phe Ser Tyr Tyr Gly Leu 
    450                 455                 460                 


Thr Val Trp Phe Pro Asp Met Ile Arg His Leu Gln Ala Val Asp Tyr 
465                 470                 475                 480 


Ala Ser Arg Thr Lys Val Phe Pro Gly Glu Arg Val Glu His Val Thr 
                485                 490                 495     


Phe Asn Phe Thr Leu Glu Asn Gln Ile His Arg Gly Gly Gln Tyr Phe 
            500                 505                 510         


Asn Asp Lys Phe Ile Gly Leu Arg Leu Lys Ser Val Ser Phe Glu Asp 
        515                 520                 525             


Ser Leu Phe Glu Glu Cys Tyr Phe Glu Asp Val Thr Ser Ser Asn Thr 
    530                 535                 540                 


Phe Phe Arg Asn Cys Thr Phe Ile Asn Thr Val Phe Tyr Asn Thr Asp 
545                 550                 555                 560 


Leu Phe Glu Tyr Lys Phe Val Asn Ser Arg Leu Ile Asn Ser Thr Phe 
                565                 570                 575     


Leu His Asn Lys Glu Gly Cys Pro Leu Asp Val Thr Gly Thr Gly Glu 
            580                 585                 590         


Gly Ala Tyr Met Val Tyr Phe Val Ser Phe Leu Gly Thr Leu Ala Val 
        595                 600                 605             


Leu Pro Gly Asn Ile Val Ser Ala Leu Leu Met Asp Lys Ile Gly Arg 
    610                 615                 620                 


Leu Arg Met Leu Ala Gly Ser Ser Val Met Ser Cys Val Ser Cys Phe 
625                 630                 635                 640 


Phe Leu Ser Phe Gly Asn Ser Glu Ser Ala Met Ile Ala Leu Leu Cys 
                645                 650                 655     


Leu Phe Gly Gly Val Ser Ile Ala Ser Trp Asn Ala Leu Asp Val Leu 
            660                 665                 670         


Thr Val Glu Leu Tyr Pro Ser Asp Lys Arg Thr Thr Ala Phe Gly Phe 
        675                 680                 685             


Leu Asn Ala Leu Cys Lys Leu Ala Ala Val Leu Gly Ile Ser Ile Phe 
    690                 695                 700                 


Thr Ser Phe Val Gly Ile Thr Lys Ala Ala Pro Ile Leu Phe Ala Ser 
705                 710                 715                 720 


Ala Ala Leu Ala Leu Gly Ser Ser Leu Ala Leu Lys Leu Pro Glu Thr 
                725                 730                 735     


Arg Gly Gln Val Leu Gln 
            740         


<210>  4000
<211>  709
<212>  PRT
<213>  Homo sapiens

<400>  4000

Met Lys Arg Cys Arg Ser Asp Glu Leu Gln Gln Gln Gln Gly Glu Glu 
1               5                   10                  15      


Asp Gly Ala Gly Leu Glu Asp Ala Ala Ser His Leu Pro Gly Ala Asp 
            20                  25                  30          


Leu Arg Pro Gly Glu Thr Thr Gly Ala Asn Ser Ala Gly Gly Pro Thr 
        35                  40                  45              


Ser Asp Ala Gly Ala Ala Ala Ala Pro Asn Pro Gly Pro Arg Ser Lys 
    50                  55                  60                  


Pro Pro Asp Leu Lys Lys Ile Gln Gln Leu Ser Glu Gly Ser Met Phe 
65                  70                  75                  80  


Gly His Gly Leu Lys His Leu Phe His Ser Arg Arg Arg Ser Arg Glu 
                85                  90                  95      


Arg Glu His Gln Thr Ser Gln Asp Ser Gln Gln His Gln Gln Gln Gln 
            100                 105                 110         


Gly Met Ser Asp His Asp Ser Pro Asp Glu Lys Glu Arg Ser Pro Glu 
        115                 120                 125             


Met His Arg Val Ser Tyr Ala Met Ser Leu His Asp Leu Pro Ala Arg 
    130                 135                 140                 


Pro Thr Ala Phe Asn Arg Val Leu Gln Gln Ile Arg Ser Arg Pro Ser 
145                 150                 155                 160 


Ile Lys Arg Gly Ala Ser Leu His Ser Ser Ser Gly Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Ser Ser Arg Arg Thr Lys Ser Ser Ser Leu Glu Pro Gln Arg 
            180                 185                 190         


Gly Ser Pro His Leu Leu Arg Lys Ala Pro Gln Asp Ser Ser Leu Ala 
        195                 200                 205             


Ala Ile Leu His Gln His Gln Cys Arg Pro Arg Ser Ser Ser Thr Thr 
    210                 215                 220                 


Asp Thr Ala Leu Leu Leu Ala Asp Gly Ser Asn Val Tyr Leu Leu Ala 
225                 230                 235                 240 


Glu Glu Ala Glu Gly Ile Gly Asp Lys Val Asp Lys Gly Asp Leu Val 
                245                 250                 255     


Ala Leu Ser Leu Pro Ala Gly His Gly Asp Thr Asp Gly Pro Ile Ser 
            260                 265                 270         


Leu Asp Val Pro Asp Gly Ala Pro Asp Pro Gln Arg Thr Lys Ala Ala 
        275                 280                 285             


Ile Asp His Leu His Gln Lys Ile Leu Lys Ile Thr Glu Gln Ile Lys 
    290                 295                 300                 


Ile Glu Gln Glu Ala Arg Asp Asp Asn Val Ala Glu Tyr Leu Lys Leu 
305                 310                 315                 320 


Ala Asn Asn Ala Asp Lys Gln Gln Val Ser Arg Ile Lys Gln Val Phe 
                325                 330                 335     


Glu Lys Lys Asn Gln Lys Ser Ala Gln Thr Ile Ala Gln Leu His Lys 
            340                 345                 350         


Lys Leu Glu His Tyr Arg Arg Arg Leu Lys Glu Ile Glu Gln Asn Gly 
        355                 360                 365             


Pro Ser Arg Gln Pro Lys Asp Val Leu Arg Asp Met Gln Gln Gly Leu 
    370                 375                 380                 


Lys Asp Val Gly Ala Asn Val Arg Ala Gly Ile Ser Gly Phe Gly Gly 
385                 390                 395                 400 


Gly Val Val Glu Gly Val Lys Gly Ser Leu Ser Gly Leu Ser Gln Ala 
                405                 410                 415     


Thr His Thr Ala Val Val Ser Lys Pro Arg Glu Phe Ala Ser Leu Ile 
            420                 425                 430         


Arg Asn Lys Phe Gly Ser Ala Asp Asn Ile Ala His Leu Lys Asp Pro 
        435                 440                 445             


Leu Glu Asp Gly Pro Pro Glu Glu Ala Ala Arg Ala Leu Ser Gly Ser 
    450                 455                 460                 


Ala Thr Leu Val Ser Ser Pro Lys Tyr Gly Ser Asp Asp Glu Cys Ser 
465                 470                 475                 480 


Ser Ala Ser Ala Ser Ser Ala Gly Ala Gly Ser Asn Ser Gly Ala Gly 
                485                 490                 495     


Pro Gly Gly Ala Leu Gly Ser Pro Lys Ser Asn Ala Leu Tyr Gly Ala 
            500                 505                 510         


Pro Gly Asn Leu Asp Ala Leu Leu Glu Glu Leu Arg Glu Ile Lys Glu 
        515                 520                 525             


Gly Gln Ser His Leu Glu Asp Ser Met Glu Asp Leu Lys Thr Gln Leu 
    530                 535                 540                 


Gln Arg Asp Tyr Thr Tyr Met Thr Gln Cys Leu Gln Glu Glu Arg Tyr 
545                 550                 555                 560 


Arg Tyr Glu Arg Leu Glu Glu Gln Leu Asn Asp Leu Thr Glu Leu His 
                565                 570                 575     


Gln Asn Glu Met Thr Asn Leu Lys Gln Glu Leu Ala Ser Met Glu Glu 
            580                 585                 590         


Lys Val Ala Tyr Gln Ser Tyr Glu Arg Ala Arg Asp Ile Gln Glu Ala 
        595                 600                 605             


Val Glu Ser Cys Leu Thr Arg Val Thr Lys Leu Glu Leu Gln Gln Gln 
    610                 615                 620                 


Gln Gln Gln Val Val Gln Leu Glu Gly Val Glu Asn Ala Asn Ala Arg 
625                 630                 635                 640 


Ala Leu Leu Gly Lys Phe Ile Asn Val Ile Leu Ala Leu Met Ala Val 
                645                 650                 655     


Leu Leu Val Phe Val Ser Thr Ile Ala Asn Phe Ile Thr Pro Leu Met 
            660                 665                 670         


Lys Thr Arg Leu Arg Ile Thr Ser Thr Thr Leu Leu Val Leu Val Leu 
        675                 680                 685             


Phe Leu Leu Trp Lys His Trp Asp Ser Leu Thr Tyr Leu Leu Glu His 
    690                 695                 700                 


Val Leu Leu Pro Ser 
705                 


<210>  4001
<211>  946
<212>  PRT
<213>  Homo sapiens

<400>  4001

Met Val Glu Gly Arg Val Ser Glu Phe Leu Lys Lys Leu Gly Phe Ser 
1               5                   10                  15      


Gly Gly Gly Arg Gln Tyr Gln Ala Leu Glu Lys Asp Glu Glu Glu Ala 
            20                  25                  30          


Leu Ile Asp Glu Gln Ser Glu Leu Lys Ala Ile Glu Lys Glu Lys Lys 
        35                  40                  45              


Val Thr Ala Leu Pro Pro Lys Glu Ala Cys Lys Cys Gln Lys Glu Asp 
    50                  55                  60                  


Leu Ala Arg Ala Phe Cys Val Asp Leu His Thr Gly Leu Ser Glu Phe 
65                  70                  75                  80  


Ser Val Thr Gln Arg Arg Leu Ala His Gly Trp Asn Glu Phe Val Ala 
                85                  90                  95      


Asp Asn Ser Glu Pro Val Trp Lys Lys Tyr Leu Asp Gln Phe Lys Asn 
            100                 105                 110         


Pro Leu Ile Leu Leu Leu Leu Gly Ser Ala Leu Val Ser Val Leu Thr 
        115                 120                 125             


Lys Glu Tyr Glu Asp Ala Val Ser Ile Ala Thr Ala Val Leu Val Val 
    130                 135                 140                 


Val Thr Val Ala Phe Ile Gln Glu Tyr Arg Ser Glu Lys Ser Leu Glu 
145                 150                 155                 160 


Glu Leu Thr Lys Leu Val Pro Pro Glu Cys Asn Cys Leu Arg Glu Gly 
                165                 170                 175     


Lys Leu Gln His Leu Leu Ala Arg Glu Leu Val Pro Gly Asp Val Val 
            180                 185                 190         


Ser Leu Ser Ile Gly Asp Arg Ile Pro Ala Asp Ile Arg Leu Thr Glu 
        195                 200                 205             


Val Thr Asp Leu Leu Val Asp Glu Ser Ser Phe Thr Gly Glu Ala Glu 
    210                 215                 220                 


Pro Cys Ser Lys Thr Asp Ser Pro Leu Thr Gly Gly Gly Asp Leu Thr 
225                 230                 235                 240 


Thr Leu Ser Asn Ile Val Phe Met Gly Thr Leu Val Gln Tyr Gly Arg 
                245                 250                 255     


Gly Gln Gly Val Val Ile Gly Thr Gly Glu Ser Ser Gln Phe Gly Glu 
            260                 265                 270         


Val Phe Lys Met Met Gln Ala Glu Glu Thr Pro Lys Thr Pro Leu Gln 
        275                 280                 285             


Lys Ser Met Asp Arg Leu Gly Lys Gln Leu Thr Leu Phe Ser Phe Gly 
    290                 295                 300                 


Ile Ile Gly Leu Ile Met Leu Ile Gly Trp Ser Gln Gly Lys Gln Leu 
305                 310                 315                 320 


Leu Ser Met Phe Thr Ile Gly Val Ser Leu Ala Val Ala Ala Ile Pro 
                325                 330                 335     


Glu Gly Leu Pro Ile Val Val Met Val Thr Leu Val Leu Gly Val Leu 
            340                 345                 350         


Arg Met Ala Lys Lys Arg Val Ile Val Lys Lys Leu Pro Ile Val Glu 
        355                 360                 365             


Thr Leu Gly Cys Cys Ser Val Leu Cys Ser Asp Lys Thr Gly Thr Leu 
    370                 375                 380                 


Thr Ala Asn Glu Met Thr Val Thr Gln Leu Val Thr Ser Asp Gly Leu 
385                 390                 395                 400 


Arg Ala Glu Val Ser Gly Val Gly Tyr Asp Gly Gln Gly Thr Val Cys 
                405                 410                 415     


Leu Leu Pro Ser Lys Glu Val Ile Lys Glu Phe Ser Asn Val Ser Val 
            420                 425                 430         


Gly Lys Leu Val Glu Ala Gly Cys Val Ala Asn Asn Ala Val Ile Arg 
        435                 440                 445             


Lys Asn Ala Val Met Gly Gln Pro Thr Glu Gly Ala Leu Met Ala Leu 
    450                 455                 460                 


Ala Met Lys Met Asp Leu Ser Asp Ile Lys Asn Ser Tyr Ile Arg Lys 
465                 470                 475                 480 


Lys Glu Ile Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys Cys 
                485                 490                 495     


Ser Leu Lys Thr Glu Asp Gln Glu Asp Ile Tyr Phe Met Lys Gly Ala 
            500                 505                 510         


Leu Glu Glu Val Ile Arg Tyr Cys Thr Met Tyr Asn Asn Gly Gly Ile 
        515                 520                 525             


Pro Leu Pro Leu Thr Pro Gln Gln Arg Ser Phe Cys Leu Gln Glu Glu 
    530                 535                 540                 


Lys Arg Met Gly Ser Leu Gly Leu Arg Val Leu Ala Leu Ala Ser Gly 
545                 550                 555                 560 


Pro Glu Leu Gly Arg Leu Thr Phe Leu Gly Leu Val Gly Ile Ile Asp 
                565                 570                 575     


Pro Pro Arg Val Gly Val Lys Glu Ala Val Gln Val Leu Ser Glu Ser 
            580                 585                 590         


Gly Val Ser Val Lys Met Ile Thr Gly Asp Ala Leu Glu Thr Ala Leu 
        595                 600                 605             


Ala Ile Gly Arg Asn Ile Gly Leu Cys Asn Gly Lys Leu Gln Ala Met 
    610                 615                 620                 


Ser Gly Glu Glu Val Asp Ser Val Glu Lys Gly Glu Leu Ala Asp Arg 
625                 630                 635                 640 


Val Gly Lys Val Ser Val Phe Phe Arg Thr Ser Pro Lys His Lys Leu 
                645                 650                 655     


Lys Ile Ile Lys Ala Leu Gln Glu Ser Gly Ala Ile Val Ala Met Thr 
            660                 665                 670         


Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ser Ala Asp Ile Gly 
        675                 680                 685             


Ile Ala Met Gly Gln Thr Gly Thr Asp Val Ser Lys Glu Ala Ala Asn 
    690                 695                 700                 


Met Ile Leu Val Asp Asp Asp Phe Ser Ala Ile Met Asn Ala Val Glu 
705                 710                 715                 720 


Glu Gly Lys Gly Ile Phe Tyr Asn Ile Lys Asn Phe Val Arg Phe Gln 
                725                 730                 735     


Leu Ser Thr Ser Ile Ser Ala Leu Ser Leu Ile Thr Leu Ser Thr Val 
            740                 745                 750         


Phe Asn Leu Pro Ser Pro Leu Asn Ala Met Gln Ile Leu Trp Ile Asn 
        755                 760                 765             


Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu Pro Val 
    770                 775                 780                 


Asp Lys Asp Ala Phe Arg Gln Pro Pro Arg Ser Val Arg Asp Thr Ile 
785                 790                 795                 800 


Leu Ser Arg Ala Leu Ile Leu Lys Ile Leu Met Ser Ala Ala Ile Ile 
                805                 810                 815     


Ile Ser Gly Thr Leu Phe Ile Phe Trp Lys Glu Met Pro Glu Asp Arg 
            820                 825                 830         


Ala Ser Thr Pro Arg Thr Thr Thr Met Thr Phe Thr Cys Phe Val Phe 
        835                 840                 845             


Phe Asp Leu Phe Asn Ala Leu Thr Cys Arg Ser Gln Thr Lys Leu Ile 
    850                 855                 860                 


Phe Glu Ile Gly Phe Leu Arg Asn His Met Phe Leu Tyr Ser Val Leu 
865                 870                 875                 880 


Gly Ser Ile Leu Gly Gln Leu Ala Val Ile Tyr Ile Pro Pro Leu Gln 
                885                 890                 895     


Arg Val Phe Gln Thr Glu Asn Leu Gly Ala Leu Asp Leu Leu Phe Leu 
            900                 905                 910         


Thr Gly Leu Ala Ser Ser Val Phe Ile Leu Ser Glu Leu Leu Lys Leu 
        915                 920                 925             


Cys Glu Lys Tyr Cys Cys Ser Pro Lys Arg Val Gln Met His Pro Glu 
    930                 935                 940                 


Asp Val 
945     


<210>  4002
<211>  409
<212>  PRT
<213>  Homo sapiens

<400>  4002

Met Lys Leu Lys Gln Arg Val Val Leu Leu Ala Ile Leu Leu Val Ile 
1               5                   10                  15      


Phe Ile Phe Thr Lys Val Phe Leu Ile Asp Asn Leu Asp Thr Ser Ala 
            20                  25                  30          


Ala Asn Arg Glu Asp Gln Arg Ala Phe His Arg Met Met Thr Gly Leu 
        35                  40                  45              


Arg Val Glu Leu Ala Pro Lys Leu Asp His Thr Leu Gln Ser Pro Trp 
    50                  55                  60                  


Glu Ile Ala Ala Gln Trp Val Val Pro Arg Glu Val Tyr Pro Glu Glu 
65                  70                  75                  80  


Thr Pro Glu Leu Gly Ala Val Met His Ala Met Ala Thr Lys Lys Ile 
                85                  90                  95      


Ile Lys Ala Asp Val Gly Tyr Lys Gly Thr Gln Leu Lys Ala Leu Leu 
            100                 105                 110         


Ile Leu Glu Gly Gly Gln Lys Val Val Phe Lys Pro Lys Arg Tyr Ser 
        115                 120                 125             


Arg Asp His Val Val Glu Gly Glu Pro Tyr Ala Gly Tyr Asp Arg His 
    130                 135                 140                 


Asn Ala Glu Val Ala Ala Phe His Leu Asp Arg Ile Leu Gly Phe His 
145                 150                 155                 160 


Arg Ala Pro Leu Val Val Gly Arg Phe Val Asn Leu Arg Thr Glu Ile 
                165                 170                 175     


Lys Pro Val Ala Thr Glu Gln Leu Leu Ser Thr Phe Leu Thr Val Gly 
            180                 185                 190         


Asn Asn Thr Cys Phe Tyr Gly Lys Cys Tyr Tyr Cys Arg Glu Thr Glu 
        195                 200                 205             


Pro Ala Cys Ala Asp Gly Asp Ile Met Glu Gly Ser Val Thr Leu Trp 
    210                 215                 220                 


Leu Pro Asp Val Trp Pro Leu Gln Lys His Arg His Pro Trp Gly Arg 
225                 230                 235                 240 


Thr Tyr Arg Glu Gly Lys Leu Ala Arg Trp Glu Tyr Asp Glu Ser Tyr 
                245                 250                 255     


Cys Asp Ala Val Lys Lys Thr Ser Pro Tyr Asp Ser Gly Pro Arg Leu 
            260                 265                 270         


Leu Asp Ile Ile Asp Thr Ala Val Phe Asp Tyr Leu Ile Gly Asn Ala 
        275                 280                 285             


Asp Arg His His Tyr Glu Ser Phe Gln Asp Asp Glu Gly Ala Ser Met 
    290                 295                 300                 


Leu Ile Leu Leu Asp Asn Ala Lys Ser Phe Gly Asn Pro Ser Leu Asp 
305                 310                 315                 320 


Glu Arg Ser Ile Leu Ala Pro Leu Tyr Gln Cys Cys Ile Ile Arg Val 
                325                 330                 335     


Ser Thr Trp Asn Arg Leu Asn Tyr Leu Lys Asn Gly Val Leu Lys Ser 
            340                 345                 350         


Ala Leu Lys Ser Ala Met Ala His Asp Pro Ile Ser Pro Val Leu Ser 
        355                 360                 365             


Asp Pro His Leu Asp Ala Val Asp Gln Arg Leu Leu Ser Val Leu Ala 
    370                 375                 380                 


Thr Val Lys Gln Cys Thr Asp Gln Phe Gly Met Asp Thr Val Leu Val 
385                 390                 395                 400 


Glu Asp Arg Met Pro Leu Ser His Leu 
                405                 


<210>  4003
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  4003

Met Ala Ile Thr Leu Glu Glu Ala Pro Trp Leu Gly Trp Leu Leu Val 
1               5                   10                  15      


Lys Ala Leu Met Arg Phe Ala Phe Met Val Val Asn Asn Leu Val Ala 
            20                  25                  30          


Ile Pro Ser Tyr Ile Cys Tyr Val Ile Ile Leu Gln Pro Leu Arg Val 
        35                  40                  45              


Leu Asp Ser Lys Arg Phe Trp Tyr Ile Glu Gly Ile Met Tyr Lys Trp 
    50                  55                  60                  


Leu Leu Gly Met Val Ala Ser Trp Gly Trp Tyr Ala Gly Tyr Thr Val 
65                  70                  75                  80  


Met Glu Trp Gly Glu Asp Ile Lys Ala Val Ser Lys Asp Glu Ala Val 
                85                  90                  95      


Met Leu Val Asn His Gln Ala Thr Gly Asp Val Cys Thr Leu Met Met 
            100                 105                 110         


Cys Leu Gln Asp Lys Gly Leu Val Val Ala Gln Met Met Trp Leu Met 
        115                 120                 125             


Asp His Ile Phe Lys Tyr Thr Asn Phe Gly Ile Val Ser Leu Val His 
    130                 135                 140                 


Gly Asp Phe Phe Ile Arg Gln Gly Arg Ser Tyr Arg Asp Gln Gln Leu 
145                 150                 155                 160 


Leu Leu Leu Lys Lys His Leu Glu Asn Asn Tyr Arg Ser Arg Asp Arg 
                165                 170                 175     


Lys Trp Ile Val Leu Phe Pro Glu Gly Gly Phe Leu Arg Lys Arg Arg 
            180                 185                 190         


Glu Thr Ser Gln Ala Phe Ala Lys Lys Asn Asn Leu Pro Phe Leu Thr 
        195                 200                 205             


Asn Val Thr Leu Pro Arg Ser Gly Ala Thr Lys Ile Ile Leu Asn Ala 
    210                 215                 220                 


Leu Val Ala Gln Gln Lys Asn Gly Ser Pro Ala Gly Gly Asp Ala Lys 
225                 230                 235                 240 


Glu Leu Asp Ser Lys Ser Lys Gly Leu Gln Trp Ile Ile Asp Thr Thr 
                245                 250                 255     


Ile Ala Tyr Pro Lys Ala Glu Pro Ile Asp Ile Gln Thr Trp Ile Leu 
            260                 265                 270         


Gly Tyr Arg Lys Pro Thr Val Thr His Val His Tyr Arg Ile Phe Pro 
        275                 280                 285             


Ile Lys Asp Val Pro Leu Glu Thr Asp Asp Leu Thr Thr Trp Leu Tyr 
    290                 295                 300                 


Gln Arg Phe Val Glu Lys Glu Asp Leu Leu Ser His Phe Tyr Glu Thr 
305                 310                 315                 320 


Gly Ala Phe Pro Pro Ser Lys Gly His Lys Glu Ala Val Ser Arg Glu 
                325                 330                 335     


Met Thr Leu Ser Asn Leu Trp Ile Phe Leu Ile Gln Ser Phe Ala Phe 
            340                 345                 350         


Leu Ser Gly Tyr Met Trp Tyr Asn Ile Ile Gln Tyr Phe Tyr His Cys 
        355                 360                 365             


Leu Phe 
    370 


<210>  4004
<211>  757
<212>  PRT
<213>  Homo sapiens

<400>  4004

Met Ser Leu Leu Phe Ser Arg Cys Asn Ser Ile Val Thr Val Lys Lys 
1               5                   10                  15      


Asn Lys Arg His Met Ala Glu Val Asn Ala Ser Pro Leu Lys His Phe 
            20                  25                  30          


Val Thr Ala Lys Lys Lys Ile Asn Gly Ile Phe Glu Gln Leu Gly Ala 
        35                  40                  45              


Tyr Ile Gln Glu Ser Ala Thr Phe Leu Glu Asp Thr Tyr Arg Asn Ala 
    50                  55                  60                  


Glu Leu Asp Pro Val Thr Thr Glu Glu Gln Val Leu Asp Val Lys Gly 
65                  70                  75                  80  


Tyr Leu Ser Lys Val Arg Gly Ile Ser Glu Val Leu Ala Arg Arg His 
                85                  90                  95      


Met Lys Val Ala Phe Phe Gly Arg Thr Ser Asn Gly Lys Ser Thr Val 
            100                 105                 110         


Ile Asn Ala Met Leu Trp Asp Lys Val Leu Pro Ser Gly Ile Gly His 
        115                 120                 125             


Thr Thr Asn Cys Phe Leu Arg Val Glu Gly Thr Asp Gly His Glu Ala 
    130                 135                 140                 


Phe Leu Leu Thr Glu Gly Ser Glu Glu Lys Arg Ser Ala Lys Thr Val 
145                 150                 155                 160 


Asn Gln Leu Ala His Ala Leu His Gln Asp Lys Gln Leu His Ala Gly 
                165                 170                 175     


Ser Leu Val Ser Val Met Trp Pro Asn Ser Lys Cys Pro Leu Leu Lys 
            180                 185                 190         


Asp Asp Leu Val Leu Met Asp Ser Pro Gly Ile Asp Val Thr Thr Glu 
        195                 200                 205             


Leu Asp Ser Trp Ile Asp Lys Phe Cys Leu Asp Ala Asp Val Phe Val 
    210                 215                 220                 


Leu Val Ala Asn Ser Glu Ser Thr Leu Met Gln Thr Glu Lys His Phe 
225                 230                 235                 240 


Phe His Lys Val Ser Glu Arg Leu Ser Arg Pro Asn Ile Phe Ile Leu 
                245                 250                 255     


Asn Asn Arg Trp Asp Ala Ser Ala Ser Glu Pro Glu Tyr Met Glu Glu 
            260                 265                 270         


Val Arg Arg Gln His Met Glu Arg Cys Thr Ser Phe Leu Val Asp Glu 
        275                 280                 285             


Leu Gly Val Val Asp Arg Ser Gln Ala Gly Asp Arg Ile Phe Phe Val 
    290                 295                 300                 


Ser Ala Lys Glu Val Leu Asn Ala Arg Ile Gln Lys Ala Gln Gly Met 
305                 310                 315                 320 


Pro Glu Gly Gly Gly Ala Leu Ala Glu Gly Phe Gln Val Arg Met Phe 
                325                 330                 335     


Glu Phe Gln Asn Phe Glu Arg Arg Phe Glu Glu Cys Ile Ser Gln Ser 
            340                 345                 350         


Ala Val Lys Thr Lys Phe Glu Gln His Thr Val Arg Ala Lys Gln Ile 
        355                 360                 365             


Ala Glu Ala Val Arg Leu Ile Met Asp Ser Leu His Met Ala Ala Arg 
    370                 375                 380                 


Glu Gln Gln Val Tyr Cys Glu Glu Met Arg Glu Glu Arg Gln Asp Arg 
385                 390                 395                 400 


Leu Lys Phe Ile Asp Lys Gln Leu Glu Leu Leu Ala Gln Asp Tyr Lys 
                405                 410                 415     


Leu Arg Ile Lys Gln Ile Thr Glu Glu Val Glu Arg Gln Val Ser Thr 
            420                 425                 430         


Ala Met Ala Glu Glu Ile Arg Arg Leu Ser Val Leu Val Asp Asp Tyr 
        435                 440                 445             


Gln Met Asp Phe His Pro Ser Pro Val Val Leu Lys Val Tyr Lys Asn 
    450                 455                 460                 


Glu Leu His Arg His Ile Glu Glu Gly Leu Gly Arg Asn Met Ser Asp 
465                 470                 475                 480 


Arg Cys Ser Thr Ala Ile Thr Asn Ser Leu Gln Thr Met Gln Gln Asp 
                485                 490                 495     


Met Ile Asp Gly Leu Lys Pro Leu Leu Pro Val Ser Val Arg Ser Gln 
            500                 505                 510         


Ile Asp Met Leu Val Pro Arg Gln Cys Phe Ser Leu Asn Tyr Asp Leu 
        515                 520                 525             


Asn Cys Asp Lys Leu Cys Ala Asp Phe Gln Glu Asp Ile Glu Phe His 
    530                 535                 540                 


Phe Ser Leu Gly Trp Thr Met Leu Val Asn Arg Phe Leu Gly Pro Lys 
545                 550                 555                 560 


Asn Ser Arg Arg Ala Leu Met Gly Tyr Asn Asp Gln Val Gln Arg Pro 
                565                 570                 575     


Ile Pro Leu Thr Pro Ala Asn Pro Ser Met Pro Pro Leu Pro Gln Gly 
            580                 585                 590         


Ser Leu Thr Gln Glu Glu Phe Met Val Ser Met Val Thr Gly Leu Ala 
        595                 600                 605             


Ser Leu Thr Ser Arg Thr Ser Met Gly Ile Leu Val Val Gly Gly Val 
    610                 615                 620                 


Val Trp Lys Ala Val Gly Trp Arg Leu Ile Ala Leu Ser Phe Gly Leu 
625                 630                 635                 640 


Tyr Gly Leu Leu Tyr Val Tyr Glu Arg Leu Thr Trp Thr Thr Lys Ala 
                645                 650                 655     


Lys Glu Arg Ala Phe Lys Arg Gln Phe Val Glu His Ala Ser Glu Lys 
            660                 665                 670         


Leu Gln Leu Val Ile Ser Tyr Thr Gly Ser Asn Cys Ser His Gln Val 
        675                 680                 685             


Gln Gln Glu Leu Ser Gly Thr Phe Ala His Leu Cys Gln Gln Val Asp 
    690                 695                 700                 


Val Thr Arg Glu Asn Leu Glu Gln Glu Ile Ala Ala Met Asn Lys Lys 
705                 710                 715                 720 


Ile Glu Val Leu Asp Ser Leu Gln Ser Lys Ala Lys Leu Leu Arg Asn 
                725                 730                 735     


Lys Ala Gly Trp Leu Asp Ser Glu Leu Asn Met Phe Thr His Gln Tyr 
            740                 745                 750         


Leu Gln Pro Ser Arg 
        755         


<210>  4005
<211>  1942
<212>  PRT
<213>  Homo sapiens

<400>  4005

Met Glu Asp Arg Arg Ala Glu Lys Ser Cys Glu Gln Ala Cys Glu Ser 
1               5                   10                  15      


Leu Lys Arg Gln Asp Tyr Glu Met Ala Leu Lys His Cys Thr Glu Ala 
            20                  25                  30          


Leu Leu Ser Leu Gly Gln Tyr Ser Met Ala Asp Phe Thr Gly Pro Cys 
        35                  40                  45              


Pro Leu Glu Ile Glu Arg Ile Lys Ile Glu Ser Leu Leu Tyr Arg Ile 
    50                  55                  60                  


Ala Ser Phe Leu Gln Leu Lys Asn Tyr Val Gln Ala Asp Glu Asp Cys 
65                  70                  75                  80  


Arg His Val Leu Gly Glu Gly Leu Ala Lys Gly Glu Asp Ala Phe Arg 
                85                  90                  95      


Ala Val Leu Cys Cys Met Gln Leu Lys Gly Lys Leu Gln Pro Val Ser 
            100                 105                 110         


Thr Ile Leu Ala Lys Ser Leu Thr Gly Glu Ser Leu Asn Gly Met Val 
        115                 120                 125             


Thr Lys Asp Leu Thr Arg Leu Lys Thr Leu Leu Ser Glu Thr Glu Thr 
    130                 135                 140                 


Ala Thr Ser Asn Ala Leu Ser Gly Tyr His Val Glu Asp Leu Asp Glu 
145                 150                 155                 160 


Gly Ser Cys Asn Gly Trp His Phe Arg Pro Pro Pro Arg Gly Ile Thr 
                165                 170                 175     


Ser Ser Glu Glu Tyr Thr Leu Cys Lys Arg Phe Leu Glu Gln Gly Ile 
            180                 185                 190         


Cys Arg Tyr Gly Ala Gln Cys Thr Ser Ala His Ser Gln Glu Glu Leu 
        195                 200                 205             


Ala Glu Trp Gln Lys Arg Tyr Ala Ser Arg Leu Ile Lys Leu Lys Gln 
    210                 215                 220                 


Gln Asn Glu Asn Lys Gln Leu Ser Gly Ser Tyr Met Glu Thr Leu Ile 
225                 230                 235                 240 


Glu Lys Trp Met Asn Ser Leu Ser Pro Glu Lys Val Leu Ser Glu Cys 
                245                 250                 255     


Ile Glu Gly Val Lys Val Glu His Asn Pro Asp Leu Ser Val Thr Val 
            260                 265                 270         


Ser Thr Lys Lys Ser His Gln Thr Trp Thr Phe Ala Leu Thr Cys Lys 
        275                 280                 285             


Pro Ala Arg Met Leu Tyr Arg Val Ala Leu Leu Tyr Asp Ala His Arg 
    290                 295                 300                 


Pro His Phe Ser Ile Ile Ala Ile Ser Ala Gly Asp Ser Thr Thr Gln 
305                 310                 315                 320 


Val Ser Gln Glu Val Pro Glu Asn Cys Gln Glu Trp Ile Gly Gly Lys 
                325                 330                 335     


Met Ala Gln Asn Gly Leu Asp His Tyr Val Tyr Lys Val Gly Ile Ala 
            340                 345                 350         


Phe Asn Thr Glu Ile Phe Gly Thr Phe Arg Gln Thr Ile Val Phe Asp 
        355                 360                 365             


Phe Gly Leu Glu Pro Val Leu Met Gln Arg Val Met Ile Asp Ala Ala 
    370                 375                 380                 


Ser Thr Glu Asp Leu Glu Tyr Leu Met His Ala Lys Gln Gln Leu Val 
385                 390                 395                 400 


Thr Thr Ala Lys Arg Trp Asp Ser Ser Ser Lys Thr Ile Ile Asp Phe 
                405                 410                 415     


Glu Pro Asn Glu Thr Thr Asp Leu Glu Lys Ser Leu Leu Ile Arg Tyr 
            420                 425                 430         


Gln Ile Pro Leu Ser Ala Asp Gln Leu Phe Thr Gln Ser Val Leu Asp 
        435                 440                 445             


Lys Ser Leu Thr Lys Ser Asn Tyr Gln Ser Arg Leu His Asp Leu Leu 
    450                 455                 460                 


Tyr Ile Glu Glu Ile Ala Gln Tyr Lys Glu Ile Ser Lys Phe Asn Leu 
465                 470                 475                 480 


Lys Val Gln Leu Gln Ile Leu Ala Ser Phe Met Leu Thr Gly Val Ser 
                485                 490                 495     


Gly Gly Ala Lys Tyr Ala Gln Asn Gly Gln Leu Phe Gly Arg Phe Lys 
            500                 505                 510         


Leu Thr Glu Thr Leu Ser Glu Asp Thr Leu Ala Gly Arg Leu Val Met 
        515                 520                 525             


Thr Lys Val Asn Ala Val Tyr Leu Leu Pro Val Pro Lys Gln Lys Leu 
    530                 535                 540                 


Val Gln Thr Gln Gly Thr Lys Glu Lys Val Tyr Glu Ala Thr Ile Glu 
545                 550                 555                 560 


Glu Lys Thr Lys Glu Tyr Ile Phe Leu Arg Leu Ser Arg Glu Cys Cys 
                565                 570                 575     


Glu Glu Leu Asn Leu Arg Pro Asp Cys Asp Thr Gln Val Glu Leu Gln 
            580                 585                 590         


Phe Gln Leu Asn Arg Leu Pro Leu Cys Glu Met His Tyr Ala Leu Asp 
        595                 600                 605             


Arg Ile Lys Asp Asn Gly Val Leu Phe Pro Asp Ile Ser Met Thr Pro 
    610                 615                 620                 


Thr Ile Pro Trp Ser Pro Asn Arg Gln Trp Asp Glu Gln Leu Asp Pro 
625                 630                 635                 640 


Arg Leu Asn Ala Lys Gln Lys Glu Ala Val Leu Ala Ile Thr Thr Pro 
                645                 650                 655     


Leu Ala Ile Gln Leu Pro Pro Val Leu Ile Ile Gly Pro Tyr Gly Thr 
            660                 665                 670         


Gly Lys Thr Phe Thr Leu Ala Gln Ala Val Lys His Ile Leu Gln Gln 
        675                 680                 685             


Gln Glu Thr Arg Ile Leu Ile Cys Thr His Ser Asn Ser Ala Ala Asp 
    690                 695                 700                 


Leu Tyr Ile Lys Asp Tyr Leu His Pro Tyr Val Glu Ala Gly Asn Pro 
705                 710                 715                 720 


Gln Ala Arg Pro Leu Arg Val Tyr Phe Arg Asn Arg Trp Val Lys Thr 
                725                 730                 735     


Val His Pro Val Val His Gln Tyr Cys Leu Ile Ser Ser Ala His Ser 
            740                 745                 750         


Thr Phe Gln Met Pro Gln Lys Glu Asp Ile Leu Lys His Arg Val Val 
        755                 760                 765             


Val Val Thr Leu Asn Thr Ser Gln Tyr Leu Cys Gln Leu Asp Leu Glu 
    770                 775                 780                 


Pro Gly Phe Phe Thr His Ile Leu Leu Asp Glu Ala Ala Gln Ala Met 
785                 790                 795                 800 


Glu Cys Glu Thr Ile Met Pro Leu Ala Leu Ala Thr Gln Asn Thr Arg 
                805                 810                 815     


Ile Val Leu Ala Gly Asp His Met Gln Leu Ser Pro Phe Val Tyr Ser 
            820                 825                 830         


Glu Phe Ala Arg Glu Arg Asn Leu His Val Ser Leu Leu Asp Arg Leu 
        835                 840                 845             


Tyr Glu His Tyr Pro Ala Glu Phe Pro Cys Arg Ile Leu Leu Cys Glu 
    850                 855                 860                 


Asn Tyr Arg Ser His Glu Ala Ile Ile Asn Tyr Thr Ser Glu Leu Phe 
865                 870                 875                 880 


Tyr Glu Gly Lys Leu Met Ala Ser Gly Lys Gln Pro Ala His Lys Asp 
                885                 890                 895     


Phe Tyr Pro Leu Thr Phe Phe Thr Ala Arg Gly Glu Asp Val Gln Glu 
            900                 905                 910         


Lys Asn Ser Thr Ala Phe Tyr Asn Asn Ala Glu Val Phe Glu Val Val 
        915                 920                 925             


Glu Arg Val Glu Glu Leu Arg Arg Lys Trp Pro Val Ala Trp Gly Lys 
    930                 935                 940                 


Leu Asp Asp Gly Ser Ile Gly Val Val Thr Pro Tyr Ala Asp Gln Val 
945                 950                 955                 960 


Phe Arg Ile Arg Ala Glu Leu Arg Lys Lys Arg Leu Ser Asp Val Asn 
                965                 970                 975     


Val Glu Arg Val Leu Asn Val Gln Gly Lys Gln Phe Arg Val Leu Phe 
            980                 985                 990         


Leu Ser Thr Val Arg Thr Arg His  Thr Cys Lys His Lys  Gln Thr Pro 
        995                 1000                 1005             


Ile Lys  Lys Lys Glu Gln Leu  Leu Glu Asp Ser Thr  Glu Asp Leu 
    1010                 1015                 1020             


Asp Tyr  Gly Phe Leu Ser Asn  Tyr Lys Leu Leu Asn  Thr Ala Ile 
    1025                 1030                 1035             


Thr Arg  Ala Gln Ser Leu Val  Ala Val Val Gly Asp  Pro Ile Ala 
    1040                 1045                 1050             


Leu Cys  Ser Ile Gly Arg Cys  Arg Lys Phe Trp Glu  Arg Phe Ile 
    1055                 1060                 1065             


Ala Leu  Cys His Glu Asn Ser  Ser Leu His Gly Ile  Thr Phe Glu 
    1070                 1075                 1080             


Gln Ile  Lys Ala Gln Leu Glu  Ala Leu Glu Leu Lys  Lys Thr Tyr 
    1085                 1090                 1095             


Val Leu  Asn Pro Leu Ala Pro  Glu Phe Ile Pro Arg  Ala Leu Arg 
    1100                 1105                 1110             


Leu Gln  His Ser Gly Ser Thr  Asn Lys Gln Gln Gln  Ser Pro Pro 
    1115                 1120                 1125             


Lys Gly  Lys Ser Leu His His  Thr Gln Asn Asp His  Phe Gln Asn 
    1130                 1135                 1140             


Asp Gly  Ile Val Gln Pro Asn  Pro Ser Val Leu Ile  Gly Asn Pro 
    1145                 1150                 1155             


Ile Arg  Ala Tyr Thr Pro Pro  Pro Pro Leu Gly Pro  His Pro Asn 
    1160                 1165                 1170             


Leu Gly  Lys Ser Pro Ser Pro  Val Gln Arg Ile Asp  Pro His Thr 
    1175                 1180                 1185             


Gly Thr  Ser Ile Leu Tyr Val  Pro Ala Val Tyr Gly  Gly Asn Val 
    1190                 1195                 1200             


Val Met  Ser Val Pro Leu Pro  Val Pro Trp Thr Gly  Tyr Gln Gly 
    1205                 1210                 1215             


Arg Phe  Ala Val Asp Pro Arg  Ile Ile Thr His Gln  Ala Ala Met 
    1220                 1225                 1230             


Ala Tyr  Asn Met Asn Leu Leu  Gln Thr His Gly Arg  Gly Ser Pro 
    1235                 1240                 1245             


Ile Pro  Tyr Gly Leu Gly His  His Pro Pro Val Thr  Ile Gly Gln 
    1250                 1255                 1260             


Pro Gln  Asn Gln His Gln Glu  Lys Asp Gln His Glu  Gln Asn Arg 
    1265                 1270                 1275             


Asn Gly  Lys Ser Asp Thr Asn  Asn Ser Gly Pro Glu  Ile Asn Lys 
    1280                 1285                 1290             


Ile Arg  Thr Pro Glu Lys Lys  Pro Thr Glu Pro Lys  Gln Val Asp 
    1295                 1300                 1305             


Leu Glu  Ser Asn Pro Gln Asn  Arg Ser Pro Glu Ser  Arg Pro Ser 
    1310                 1315                 1320             


Val Val  Tyr Pro Ser Thr Lys  Phe Pro Arg Lys Asp  Asn Leu Asn 
    1325                 1330                 1335             


Pro Arg  His Ile Asn Leu Pro  Leu Pro Ala Pro His  Ala Gln Tyr 
    1340                 1345                 1350             


Ala Ile  Pro Asn Arg His Phe  His Pro Leu Pro Gln  Leu Pro Arg 
    1355                 1360                 1365             


Pro Pro  Phe Pro Ile Pro Gln  Gln His Thr Leu Leu  Asn Gln Gln 
    1370                 1375                 1380             


Gln Asn  Asn Leu Pro Glu Gln  Pro Asn Gln Ile Pro  Pro Gln Pro 
    1385                 1390                 1395             


Asn Gln  Val Val Gln Gln Gln  Ser Gln Leu Asn Gln  Gln Pro Gln 
    1400                 1405                 1410             


Gln Pro  Pro Pro Gln Leu Ser  Pro Ala Tyr Gln Ala  Gly Pro Asn 
    1415                 1420                 1425             


Asn Ala  Phe Phe Asn Ser Ala  Val Ala His Arg Pro  Gln Ser Pro 
    1430                 1435                 1440             


Pro Ala  Glu Ala Val Ile Pro  Glu Gln Gln Pro Pro  Pro Met Leu 
    1445                 1450                 1455             


Gln Glu  Gly His Ser Pro Leu  Arg Ala Ile Ala Gln  Pro Gly Pro 
    1460                 1465                 1470             


Ile Leu  Pro Ser His Leu Asn  Ser Phe Ile Asp Glu  Asn Pro Ser 
    1475                 1480                 1485             


Gly Leu  Pro Ile Gly Glu Ala  Leu Asp Arg Ile His  Gly Ser Val 
    1490                 1495                 1500             


Ala Leu  Glu Thr Leu Arg Gln  Gln Gln Ala Arg Phe  Gln Gln Trp 
    1505                 1510                 1515             


Ser Glu  His His Ala Phe Leu  Ser Gln Gly Ser Val  Pro Tyr Pro 
    1520                 1525                 1530             


His His  His His Pro His Leu  Gln His Leu Pro Gln  Pro Pro Leu 
    1535                 1540                 1545             


Gly Leu  His Gln Pro Pro Val  Arg Ala Asp Trp Lys  Leu Thr Ser 
    1550                 1555                 1560             


Ser Ala  Glu Asp Glu Val Glu  Thr Thr Tyr Ser Arg  Phe Gln Asp 
    1565                 1570                 1575             


Leu Ile  Arg Glu Leu Ser His  Arg Asp Gln Ser Glu  Thr Arg Glu 
    1580                 1585                 1590             


Leu Ala  Glu Met Pro Pro Pro  Gln Ser Arg Leu Leu  Gln Tyr Arg 
    1595                 1600                 1605             


Gln Val  Gln Ser Arg Ser Pro  Pro Ala Val Pro Ser  Pro Pro Ser 
    1610                 1615                 1620             


Ser Thr  Asp His Ser Ser His  Phe Ser Asn Phe Asn  Asp Asn Ser 
    1625                 1630                 1635             


Arg Asp  Ile Glu Val Ala Ser  Asn Pro Ala Phe Pro  Gln Arg Leu 
    1640                 1645                 1650             


Pro Pro  Gln Ile Phe Asn Ser  Pro Phe Ser Leu Pro  Ser Glu His 
    1655                 1660                 1665             


Leu Ala  Pro Pro Pro Leu Lys  Tyr Leu Ala Pro Asp  Gly Ala Trp 
    1670                 1675                 1680             


Thr Phe  Ala Asn Leu Gln Gln  Asn His Leu Met Gly  Pro Gly Phe 
    1685                 1690                 1695             


Pro Tyr  Gly Leu Pro Pro Leu  Pro His Arg Pro Pro  Gln Asn Pro 
    1700                 1705                 1710             


Phe Val  Gln Ile Gln Asn His  Gln His Ala Ile Gly  Gln Glu Pro 
    1715                 1720                 1725             


Phe His  Pro Leu Ser Ser Arg  Thr Val Ser Ser Ser  Ser Leu Pro 
    1730                 1735                 1740             


Ser Leu  Glu Glu Tyr Glu Pro  Arg Gly Pro Gly Arg  Pro Leu Tyr 
    1745                 1750                 1755             


Gln Arg  Arg Ile Ser Ser Ser  Ser Val Gln Pro Cys  Ser Glu Glu 
    1760                 1765                 1770             


Val Ser  Thr Pro Gln Asp Ser  Leu Ala Gln Cys Lys  Glu Leu Gln 
    1775                 1780                 1785             


Asp His  Ser Asn Gln Ser Ser  Phe Asn Phe Ser Ser  Pro Glu Ser 
    1790                 1795                 1800             


Trp Val  Asn Thr Thr Ser Ser  Thr Pro Tyr Gln Asn  Ile Pro Cys 
    1805                 1810                 1815             


Asn Gly  Ser Ser Arg Thr Ala  Gln Pro Arg Glu Leu  Ile Ala Pro 
    1820                 1825                 1830             


Pro Lys  Thr Val Lys Pro Pro  Glu Asp Gln Leu Lys  Ser Glu Asn 
    1835                 1840                 1845             


Leu Glu  Val Ser Ser Ser Phe  Asn Tyr Ser Val Leu  Gln His Leu 
    1850                 1855                 1860             


Gly Gln  Phe Pro Pro Leu Met  Pro Asn Lys Gln Ile  Ala Glu Ser 
    1865                 1870                 1875             


Ala Asn  Ser Ser Ser Pro Gln  Ser Ser Ala Gly Gly  Lys Pro Ala 
    1880                 1885                 1890             


Met Ser  Tyr Ala Ser Ala Leu  Arg Ala Pro Pro Lys  Pro Arg Pro 
    1895                 1900                 1905             


Pro Pro  Glu Gln Ala Lys Lys  Ser Ser Asp Pro Leu  Ser Leu Phe 
    1910                 1915                 1920             


Gln Glu  Leu Ser Leu Gly Ser  Ser Ser Gly Ser Asn  Gly Phe Tyr 
    1925                 1930                 1935             


Ser Tyr  Phe Lys 
    1940         


<210>  4006
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  4006

Met Ile Asn Ser Thr Ser Thr Gln Pro Pro Asp Glu Ser Cys Ser Gln 
1               5                   10                  15      


Asn Leu Leu Ile Thr Gln Gln Ile Ile Pro Val Leu Tyr Cys Met Val 
            20                  25                  30          


Phe Ile Ala Gly Ile Leu Leu Asn Gly Val Ser Gly Trp Ile Phe Phe 
        35                  40                  45              


Tyr Val Pro Ser Ser Lys Ser Phe Ile Ile Tyr Leu Lys Asn Ile Val 
    50                  55                  60                  


Ile Ala Asp Phe Val Met Ser Leu Thr Phe Pro Phe Lys Ile Leu Gly 
65                  70                  75                  80  


Asp Ser Gly Leu Gly Pro Trp Gln Leu Asn Val Phe Val Cys Arg Val 
                85                  90                  95      


Ser Ala Val Leu Phe Tyr Val Asn Met Tyr Val Ser Ile Val Phe Phe 
            100                 105                 110         


Gly Leu Ile Ser Phe Asp Arg Tyr Tyr Lys Ile Val Lys Pro Leu Trp 
        115                 120                 125             


Thr Ser Phe Ile Gln Ser Val Ser Tyr Ser Lys Leu Leu Ser Val Ile 
    130                 135                 140                 


Val Trp Met Leu Met Leu Leu Leu Ala Val Pro Asn Ile Ile Leu Thr 
145                 150                 155                 160 


Asn Gln Ser Val Arg Glu Val Thr Gln Ile Lys Cys Ile Glu Leu Lys 
                165                 170                 175     


Ser Glu Leu Gly Arg Lys Trp His Lys Ala Ser Asn Tyr Ile Phe Val 
            180                 185                 190         


Ala Ile Phe Trp Ile Val Phe Leu Leu Leu Ile Val Phe Tyr Thr Ala 
        195                 200                 205             


Ile Thr Lys Lys Ile Phe Lys Ser His Leu Lys Ser Ser Arg Asn Ser 
    210                 215                 220                 


Thr Ser Val Lys Lys Lys Ser Ser Arg Asn Ile Phe Ser Ile Val Phe 
225                 230                 235                 240 


Val Phe Phe Val Cys Phe Val Pro Tyr His Ile Ala Arg Ile Pro Tyr 
                245                 250                 255     


Thr Lys Ser Gln Thr Glu Ala His Tyr Ser Cys Gln Ser Lys Glu Ile 
            260                 265                 270         


Leu Arg Tyr Met Lys Glu Phe Thr Leu Leu Leu Ser Ala Ala Asn Val 
        275                 280                 285             


Cys Leu Asp Pro Ile Ile Tyr Phe Phe Leu Cys Gln Pro Phe Arg Glu 
    290                 295                 300                 


Ile Leu Cys Lys Lys Leu His Ile Pro Leu Lys Ala Gln Asn Asp Leu 
305                 310                 315                 320 


Asp Ile Ser Arg Ile Lys Arg Gly Asn Thr Thr Leu Glu Ser Thr Asp 
                325                 330                 335     


Thr Leu 
        


<210>  4007
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  4007

Met Leu Arg Ala Ala Leu Pro Ala Leu Leu Leu Pro Leu Leu Gly Leu 
1               5                   10                  15      


Ala Ala Ala Ala Val Ala Asp Cys Pro Ser Ser Thr Trp Ile Gln Phe 
            20                  25                  30          


Gln Asp Ser Cys Tyr Ile Phe Leu Gln Glu Ala Ile Lys Val Glu Ser 
        35                  40                  45              


Ile Glu Asp Val Arg Asn Gln Cys Thr Asp His Gly Ala Asp Met Ile 
    50                  55                  60                  


Ser Ile His Asn Glu Glu Glu Asn Ala Phe Ile Leu Asp Thr Leu Lys 
65                  70                  75                  80  


Lys Gln Trp Lys Gly Pro Asp Asp Ile Leu Leu Gly Met Phe Tyr Asp 
                85                  90                  95      


Thr Asp Asp Ala Ser Phe Lys Trp Phe Asp Asn Ser Asn Met Thr Phe 
            100                 105                 110         


Asp Lys Trp Thr Asp Gln Asp Asp Asp Glu Asp Leu Val Asp Thr Cys 
        115                 120                 125             


Ala Phe Leu His Ile Lys Thr Gly Glu Trp Lys Lys Gly Asn Cys Glu 
    130                 135                 140                 


Val Ser Ser Val Glu Gly Thr Leu Cys Lys Thr Ala Ile Pro Tyr Lys 
145                 150                 155                 160 


Arg Lys Tyr Leu Ser Asp Asn His Ile Leu Ile Ser Ala Leu Val Ile 
                165                 170                 175     


Ala Ser Thr Val Ile Leu Thr Val Leu Gly Ala Ile Ile Trp Phe Leu 
            180                 185                 190         


Tyr Lys Lys His Ser Asp Ser Arg Phe Thr Thr Val Phe Ser Thr Ala 
        195                 200                 205             


Pro Gln Ser Pro Tyr Asn Glu Asp Cys Val Leu Val Val Gly Glu Glu 
    210                 215                 220                 


Asn Glu Tyr Pro Val Gln Phe Asp 
225                 230         


<210>  4008
<211>  583
<212>  PRT
<213>  Homo sapiens

<400>  4008

Met Ser Tyr Gly Glu Ile Glu Gly Lys Phe Leu Gly Pro Arg Glu Glu 
1               5                   10                  15      


Val Thr Ser Glu Pro Arg Cys Lys Lys Leu Lys Ser Thr Thr Glu Ser 
            20                  25                  30          


Tyr Val Phe His Asn His Ser Asn Ala Asp Phe His Arg Ile Gln Glu 
        35                  40                  45              


Lys Thr Gly Asn Asp Trp Val Pro Val Thr Ile Ile Asp Val Arg Gly 
    50                  55                  60                  


His Ser Tyr Leu Gln Glu Asn Lys Ile Lys Thr Thr Asp Leu His Arg 
65                  70                  75                  80  


Pro Leu His Asp Glu Met Pro Gly Asn Arg Pro Asp Val Ile Glu Ser 
                85                  90                  95      


Ile Asp Ser Gln Val Leu Gln Glu Ala Arg Pro Pro Leu Val Ser Ala 
            100                 105                 110         


Asp Asp Glu Ile Tyr Ser Thr Ser Lys Ala Phe Ile Gly Pro Ile Tyr 
        115                 120                 125             


Lys Pro Pro Glu Lys Lys Lys Arg Asn Glu Gly Arg Asn Glu Ala His 
    130                 135                 140                 


Val Leu Asn Gly Ile Asn Asp Arg Gly Gly Gln Lys Glu Lys Gln Lys 
145                 150                 155                 160 


Phe Asn Ser Glu Lys Ser Glu Ile Asp Asn Glu Leu Phe Gln Phe Tyr 
                165                 170                 175     


Lys Glu Ile Glu Glu Leu Glu Lys Glu Lys Asp Gly Phe Glu Asn Ser 
            180                 185                 190         


Cys Lys Glu Ser Glu Pro Ser Gln Glu Gln Phe Val Pro Phe Tyr Glu 
        195                 200                 205             


Gly His Asn Asn Gly Leu Leu Lys Pro Asp Glu Glu Lys Lys Asp Leu 
    210                 215                 220                 


Ser Asn Lys Ala Met Pro Ser His Cys Asp Tyr Gln Gln Asn Leu Gly 
225                 230                 235                 240 


Asn Glu Pro Asp Lys Tyr Pro Cys Asn Gly Gln Val Ile Pro Thr Phe 
                245                 250                 255     


Cys Asp Thr Ser Phe Thr Ser Phe Arg Pro Glu Trp Gln Ser Val Tyr 
            260                 265                 270         


Pro Phe Ile Val Pro Tyr Gly Pro Pro Leu Pro Ser Leu Asn Tyr His 
        275                 280                 285             


Leu Asn Ile Gln Arg Phe Ser Gly Pro Pro Asn Pro Pro Ser Asn Ile 
    290                 295                 300                 


Phe Gln Ala Gln Asp Asp Ser Gln Ile Gln Asn Gly Tyr Tyr Val Asn 
305                 310                 315                 320 


Asn Cys His Val Asn Trp Asn Cys Met Thr Phe Asp Gln Asn Asn Glu 
                325                 330                 335     


Tyr Thr Asp Cys Ser Glu Asn Arg Ser Ser Val His Pro Ser Gly Asn 
            340                 345                 350         


Gly Cys Ser Met Gln Asp Arg Tyr Val Ser Asn Gly Phe Cys Glu Val 
        355                 360                 365             


Arg Glu Arg Cys Trp Lys Asp His Cys Met Asp Lys His Asn Gly Thr 
    370                 375                 380                 


Asp Arg Phe Val Asn Gln Gln Phe Gln Glu Glu Lys Leu Asn Lys Leu 
385                 390                 395                 400 


Gln Lys Leu Leu Ile Leu Leu Arg Gly Leu Pro Gly Ser Gly Lys Thr 
                405                 410                 415     


Thr Leu Ser Arg Ile Leu Leu Gly Gln Asn Arg Asp Gly Ile Val Phe 
            420                 425                 430         


Ser Thr Asp Asp Tyr Phe His His Gln Asp Gly Tyr Arg Tyr Asn Val 
        435                 440                 445             


Asn Gln Leu Gly Asp Ala His Asp Trp Asn Gln Asn Arg Ala Lys Gln 
    450                 455                 460                 


Ala Ile Asp Gln Gly Arg Ser Pro Val Ile Ile Asp Asn Thr Asn Ile 
465                 470                 475                 480 


Gln Ala Trp Glu Met Lys Pro Tyr Val Glu Val Ala Ile Gly Lys Gly 
                485                 490                 495     


Tyr Arg Val Glu Phe His Glu Pro Glu Thr Trp Trp Lys Phe Asp Pro 
            500                 505                 510         


Glu Glu Leu Glu Lys Arg Asn Lys His Gly Val Ser Arg Lys Lys Ile 
        515                 520                 525             


Ala Gln Met Leu Asp Arg Tyr Glu Tyr Gln Met Ser Ile Ser Ile Val 
    530                 535                 540                 


Met Asn Ser Val Glu Pro Ser His Lys Ser Thr Gln Arg Pro Pro Pro 
545                 550                 555                 560 


Pro Gln Gly Arg Gln Arg Trp Gly Gly Ser Leu Gly Ser His Asn Arg 
                565                 570                 575     


Val Cys Val Thr Asn Asn His 
            580             


<210>  4009
<211>  816
<212>  PRT
<213>  Homo sapiens

<400>  4009

Met Leu Arg Pro Gln Gly Leu Leu Trp Leu Pro Leu Leu Phe Thr Ser 
1               5                   10                  15      


Val Cys Val Met Leu Asn Ser Asn Val Leu Leu Trp Ile Thr Ala Leu 
            20                  25                  30          


Ala Ile Lys Phe Thr Leu Ile Asp Ser Gln Ala Gln Tyr Pro Val Val 
        35                  40                  45              


Asn Thr Asn Tyr Gly Lys Ile Gln Gly Leu Arg Thr Pro Leu Pro Ser 
    50                  55                  60                  


Glu Ile Leu Gly Pro Val Glu Gln Tyr Leu Gly Val Pro Tyr Ala Ser 
65                  70                  75                  80  


Pro Pro Thr Gly Glu Arg Arg Phe Gln Pro Pro Glu Ser Pro Ser Ser 
                85                  90                  95      


Trp Thr Gly Ile Arg Asn Ala Thr Gln Phe Ser Ala Val Cys Pro Gln 
            100                 105                 110         


His Leu Asp Glu Arg Phe Leu Leu His Asp Met Leu Pro Ile Trp Phe 
        115                 120                 125             


Thr Thr Ser Leu Asp Thr Leu Met Thr Tyr Val Gln Asp Gln Asn Glu 
    130                 135                 140                 


Asp Cys Leu Tyr Leu Asn Ile Tyr Val Pro Met Glu Asp Asp Ile His 
145                 150                 155                 160 


Glu Gln Asn Ser Lys Lys Pro Val Met Val Tyr Ile His Gly Gly Ser 
                165                 170                 175     


Tyr Met Glu Gly Thr Gly Asn Met Ile Asp Gly Ser Ile Leu Ala Ser 
            180                 185                 190         


Tyr Gly Asn Val Ile Val Ile Thr Ile Asn Tyr Arg Leu Gly Ile Leu 
        195                 200                 205             


Gly Phe Leu Ser Thr Gly Asp Gln Ala Ala Lys Gly Asn Tyr Gly Leu 
    210                 215                 220                 


Leu Asp Gln Ile Gln Ala Leu Arg Trp Ile Glu Glu Asn Val Gly Ala 
225                 230                 235                 240 


Phe Gly Gly Asp Pro Lys Arg Val Thr Ile Phe Gly Ser Gly Ala Gly 
                245                 250                 255     


Ala Ser Cys Val Ser Leu Leu Thr Leu Ser His Tyr Ser Glu Gly Leu 
            260                 265                 270         


Phe Gln Lys Ala Ile Ile Gln Ser Gly Thr Ala Leu Ser Ser Trp Ala 
        275                 280                 285             


Val Asn Tyr Gln Pro Ala Lys Tyr Thr Arg Ile Leu Ala Asp Lys Val 
    290                 295                 300                 


Gly Cys Asn Met Leu Asp Thr Thr Asp Met Val Glu Cys Leu Lys Asn 
305                 310                 315                 320 


Lys Asn Tyr Lys Glu Leu Ile Gln Gln Thr Ile Thr Pro Ala Thr Tyr 
                325                 330                 335     


His Ile Ala Phe Gly Pro Val Ile Asp Gly Asp Val Ile Pro Asp Asp 
            340                 345                 350         


Pro Gln Ile Leu Met Glu Gln Gly Glu Phe Leu Asn Tyr Asp Ile Met 
        355                 360                 365             


Leu Gly Val Asn Gln Gly Glu Gly Leu Lys Phe Val Asp Gly Ile Val 
    370                 375                 380                 


Asp Asn Glu Asp Gly Val Thr Pro Asn Asp Phe Asp Phe Ser Val Ser 
385                 390                 395                 400 


Asn Phe Val Asp Asn Leu Tyr Gly Tyr Pro Glu Gly Lys Asp Thr Leu 
                405                 410                 415     


Arg Glu Thr Ile Lys Phe Met Tyr Thr Asp Trp Ala Asp Lys Glu Asn 
            420                 425                 430         


Pro Glu Thr Arg Arg Lys Thr Leu Val Ala Leu Phe Thr Asp His Gln 
        435                 440                 445             


Trp Val Ala Pro Ala Val Ala Thr Ala Asp Leu His Ala Gln Tyr Gly 
    450                 455                 460                 


Ser Pro Thr Tyr Phe Tyr Ala Phe Tyr His His Cys Gln Ser Glu Met 
465                 470                 475                 480 


Lys Pro Ser Trp Ala Asp Ser Ala His Gly Asp Glu Val Pro Tyr Val 
                485                 490                 495     


Phe Gly Ile Pro Met Ile Gly Pro Thr Glu Leu Phe Ser Cys Asn Phe 
            500                 505                 510         


Ser Lys Asn Asp Val Met Leu Ser Ala Val Val Met Thr Tyr Trp Thr 
        515                 520                 525             


Asn Phe Ala Lys Thr Gly Asp Pro Asn Gln Pro Val Pro Gln Asp Thr 
    530                 535                 540                 


Lys Phe Ile His Thr Lys Pro Asn Arg Phe Glu Glu Val Ala Trp Ser 
545                 550                 555                 560 


Lys Tyr Asn Pro Lys Asp Gln Leu Tyr Leu His Ile Gly Leu Lys Pro 
                565                 570                 575     


Arg Val Arg Asp His Tyr Arg Ala Thr Lys Val Ala Phe Trp Leu Glu 
            580                 585                 590         


Leu Val Pro His Leu His Asn Leu Asn Glu Ile Phe Gln Tyr Val Ser 
        595                 600                 605             


Thr Thr Thr Lys Val Pro Pro Pro Asp Met Thr Ser Phe Pro Tyr Gly 
    610                 615                 620                 


Thr Arg Arg Ser Pro Ala Lys Ile Trp Pro Thr Thr Lys Arg Pro Ala 
625                 630                 635                 640 


Ile Thr Pro Ala Asn Asn Pro Lys His Ser Lys Asp Pro His Lys Thr 
                645                 650                 655     


Gly Pro Glu Asp Thr Thr Val Leu Ile Glu Thr Lys Arg Asp Tyr Ser 
            660                 665                 670         


Thr Glu Leu Ser Val Thr Ile Ala Val Gly Ala Ser Leu Leu Phe Leu 
        675                 680                 685             


Asn Ile Leu Ala Phe Ala Ala Leu Tyr Tyr Lys Lys Asp Lys Arg Arg 
    690                 695                 700                 


His Glu Thr His Arg His Pro Ser Pro Gln Arg Asn Thr Thr Asn Asp 
705                 710                 715                 720 


Ile Thr His Ile Gln Asn Glu Glu Ile Met Ser Leu Gln Met Lys Gln 
                725                 730                 735     


Leu Glu His Asp His Glu Cys Glu Ser Leu Gln Ala His Asp Thr Leu 
            740                 745                 750         


Arg Leu Thr Cys Pro Pro Asp Tyr Thr Leu Thr Leu Arg Arg Ser Pro 
        755                 760                 765             


Asp Asp Ile Pro Phe Met Thr Pro Asn Thr Ile Thr Met Ile Pro Asn 
    770                 775                 780                 


Thr Leu Met Gly Met Gln Pro Leu His Thr Phe Lys Thr Phe Ser Gly 
785                 790                 795                 800 


Gly Gln Asn Ser Thr Asn Leu Pro His Gly His Ser Thr Thr Arg Val 
                805                 810                 815     


<210>  4010
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  4010

Met Thr Arg Glu Cys Pro Ser Pro Ala Pro Gly Pro Gly Ala Pro Leu 
1               5                   10                  15      


Ser Gly Ser Val Leu Ala Glu Ala Ala Val Val Phe Ala Val Val Leu 
            20                  25                  30          


Ser Ile His Ala Thr Val Trp Asp Arg Tyr Ser Trp Cys Ala Val Ala 
        35                  40                  45              


Leu Ala Val Gln Ala Phe Tyr Val Gln Tyr Lys Trp Asp Arg Leu Leu 
    50                  55                  60                  


Gln Gln Gly Ser Ala Val Phe Gln Phe Arg Met Ser Ala Asn Ser Gly 
65                  70                  75                  80  


Leu Leu Pro Ala Ser Met Val Met Pro Leu Leu Gly Leu Val Met Lys 
                85                  90                  95      


Glu Arg Cys Gln Thr Ala Gly Asn Pro Phe Phe Glu Arg Phe Gly Ile 
            100                 105                 110         


Val Val Ala Ala Thr Gly Met Ala Val Ala Leu Phe Ser Ser Val Leu 
        115                 120                 125             


Ala Leu Gly Ile Thr Arg Pro Val Pro Thr Asn Thr Cys Val Ile Leu 
    130                 135                 140                 


Gly Leu Ala Gly Gly Val Ile Ile Tyr Ile Met Lys His Ser Leu Ser 
145                 150                 155                 160 


Val Gly Glu Val Ile Glu Val Leu Glu Val Leu Leu Ile Phe Val Tyr 
                165                 170                 175     


Leu Asn Met Ile Leu Leu Tyr Leu Leu Pro Arg Cys Phe Thr Pro Gly 
            180                 185                 190         


Glu Ala Leu Leu Val Leu Gly Gly Ile Ser Phe Val Leu Asn Gln Leu 
        195                 200                 205             


Ile Lys Arg Ser Leu Thr Leu Val Glu Ser Gln Gly Asp Pro Val Asp 
    210                 215                 220                 


Phe Phe Leu Leu Val Val Val Val Gly Met Val Leu Met Gly Ile Phe 
225                 230                 235                 240 


Phe Ser Thr Leu Phe Val Phe Met Asp Ser Gly Thr Trp Ala Ser Ser 
                245                 250                 255     


Ile Phe Phe His Leu Met Thr Cys Val Leu Ser Leu Gly Val Val Leu 
            260                 265                 270         


Pro Trp Leu His Arg Leu Ile Arg Arg Asn Pro Leu Leu Trp Leu Leu 
        275                 280                 285             


Gln Phe Leu Phe Gln Thr Asp Thr Arg Ile Tyr Leu Leu Ala Tyr Trp 
    290                 295                 300                 


Ser Leu Leu Ala Thr Leu Ala Cys Leu Val Val Leu Tyr Gln Asn Ala 
305                 310                 315                 320 


Lys Arg Ser Ser Ser Glu Ser Lys Lys His Gln Ala Pro Thr Ile Ala 
                325                 330                 335     


Arg Lys Tyr Phe His Leu Ile Val Val Ala Thr Tyr Ile Pro Gly Ile 
            340                 345                 350         


Ile Phe Asp Arg Pro Leu Leu Tyr Val Ala Ala Thr Val Cys Leu Ala 
        355                 360                 365             


Val Phe Ile Phe Leu Glu Tyr Val Arg Tyr Phe Arg Ile Lys Pro Leu 
    370                 375                 380                 


Gly His Thr Leu Arg Ser Phe Leu Ser Leu Phe Leu Asp Glu Arg Asp 
385                 390                 395                 400 


Ser Gly Pro Leu Ile Leu Thr His Ile Tyr Leu Leu Leu Gly Met Ser 
                405                 410                 415     


Leu Pro Ile Trp Leu Ile Pro Arg Pro Cys Thr Gln Lys Gly Ser Leu 
            420                 425                 430         


Gly Gly Ala Arg Ala Leu Val Pro Tyr Ala Gly Val Leu Ala Val Gly 
        435                 440                 445             


Val Gly Asp Thr Val Ala Ser Ile Phe Gly Ser Thr Met Gly Glu Ile 
    450                 455                 460                 


Arg Trp Pro Gly Thr Lys Lys Thr Phe Glu Gly Thr Met Thr Ser Ile 
465                 470                 475                 480 


Phe Ala Gln Ile Ile Ser Val Ala Leu Ile Leu Ile Phe Asp Ser Gly 
                485                 490                 495     


Val Asp Leu Asn Tyr Ser Tyr Ala Trp Ile Leu Gly Ser Ile Ser Thr 
            500                 505                 510         


Val Ser Leu Leu Glu Ala Tyr Thr Thr Gln Ile Asp Asn Leu Leu Leu 
        515                 520                 525             


Pro Leu Tyr Leu Leu Ile Leu Leu Met Ala 
    530                 535             


<210>  4011
<211>  1503
<212>  PRT
<213>  Homo sapiens

<400>  4011

Met Pro Gly Pro Pro Ala Leu Arg Arg Arg Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Val Leu Leu Ile Ala Gly Ser Ala Gly Ala Ala Pro Leu Pro Gln Thr 
            20                  25                  30          


Gly Ala Gly Glu Ala Pro Pro Ala Ala Glu Val Ser Ser Ser Phe Val 
        35                  40                  45              


Ile Leu Cys Val Cys Ser Leu Ile Ile Leu Ile Val Leu Ile Ala Asn 
    50                  55                  60                  


Cys Val Ser Cys Cys Lys Asp Pro Glu Ile Asp Phe Lys Glu Phe Glu 
65                  70                  75                  80  


Asp Asn Phe Asp Asp Glu Ile Asp Phe Thr Pro Pro Ala Glu Asp Thr 
                85                  90                  95      


Pro Ser Val Gln Ser Pro Ala Glu Val Phe Thr Leu Ser Val Pro Asn 
            100                 105                 110         


Ile Ser Leu Pro Ala Pro Ser Gln Phe Gln Pro Ser Val Glu Gly Leu 
        115                 120                 125             


Lys Ser Gln Val Ala Arg His Ser Leu Asn Tyr Ile Gln Glu Ile Gly 
    130                 135                 140                 


Asn Gly Trp Phe Gly Lys Val Leu Leu Gly Glu Ile Tyr Thr Gly Thr 
145                 150                 155                 160 


Ser Val Ala Arg Val Ile Val Lys Glu Leu Lys Ala Ser Ala Asn Pro 
                165                 170                 175     


Lys Glu Gln Asp Thr Phe Leu Lys Asn Gly Glu Pro Tyr Tyr Ile Leu 
            180                 185                 190         


Gln His Pro Asn Ile Leu Gln Cys Val Gly Gln Cys Val Glu Ala Ile 
        195                 200                 205             


Pro Tyr Leu Leu Val Phe Glu Phe Cys Asp Leu Gly Asp Leu Lys Ala 
    210                 215                 220                 


Tyr Leu Arg Ser Glu Gln Glu His Met Arg Gly Asp Ser Gln Thr Met 
225                 230                 235                 240 


Leu Leu Gln Arg Met Ala Cys Glu Val Ala Ala Gly Leu Ala Ala Met 
                245                 250                 255     


His Lys Leu His Phe Leu His Ser Asp Leu Ala Leu Arg Asn Cys Phe 
            260                 265                 270         


Leu Thr Ser Asp Leu Asn Val Lys Val Gly Asp Tyr Gly Ile Gly Phe 
        275                 280                 285             


Ser Arg Tyr Lys Glu Asp Tyr Ile Glu Thr Asp Asp Lys Lys Val Phe 
    290                 295                 300                 


Pro Leu Arg Trp Thr Ala Pro Glu Leu Val Thr Ser Phe Gln Asp Arg 
305                 310                 315                 320 


Leu Leu Thr Ala Asp Gln Thr Lys Tyr Ser Asn Ile Trp Ser Leu Gly 
                325                 330                 335     


Val Thr Leu Trp Glu Leu Phe Asp Asn Ala Ala Gln Pro Tyr Ser Asn 
            340                 345                 350         


Leu Ser Asn Leu Asp Val Leu Asn Gln Val Ile Arg Glu Arg Asp Thr 
        355                 360                 365             


Lys Leu Pro Lys Pro Gln Leu Glu Gln Pro Tyr Ser Asp Arg Trp Tyr 
    370                 375                 380                 


Glu Val Leu Gln Phe Cys Trp Leu Ser Pro Glu Lys Arg Pro Ala Ala 
385                 390                 395                 400 


Glu Asp Val His Arg Leu Leu Thr Tyr Leu Arg Leu Gln Ser Gln Arg 
                405                 410                 415     


Asp Ser Glu Val Asp Phe Glu Gln Gln Trp Asn Ala Leu Lys Pro Asn 
            420                 425                 430         


Thr Asn Ser Arg Asp Ser Ser Asn Asn Ala Ala Phe Pro Ile Leu Asp 
        435                 440                 445             


His Phe Ala Arg Asp Arg Leu Gly Arg Glu Met Glu Glu Val Leu Thr 
    450                 455                 460                 


Val Thr Glu Thr Ser Gln Gly Leu Ser Phe Glu Tyr Val Trp Glu Ala 
465                 470                 475                 480 


Ala Lys His Asp His Phe Asp Glu Arg Ser Arg Gly His Leu Asp Glu 
                485                 490                 495     


Gly Leu Ser Tyr Thr Ser Ile Phe Tyr Pro Val Glu Val Phe Glu Ser 
            500                 505                 510         


Ser Leu Ser Asp Pro Gly Pro Gly Lys Gln Asp Asp Ser Gly Gln Asp 
        515                 520                 525             


Val Pro Leu Arg Val Pro Gly Val Val Pro Val Phe Asp Ala His Asn 
    530                 535                 540                 


Leu Ser Val Gly Ser Asp Tyr Tyr Ile Gln Leu Glu Glu Lys Ser Gly 
545                 550                 555                 560 


Ser Asn Leu Glu Leu Asp Tyr Pro Pro Ala Leu Leu Thr Thr Asp Met 
                565                 570                 575     


Asp Asn Pro Glu Arg Thr Gly Pro Glu Leu Ser Gln Leu Thr Ala Leu 
            580                 585                 590         


Arg Ser Val Glu Leu Glu Glu Ser Ser Thr Asp Glu Asp Phe Phe Gln 
        595                 600                 605             


Ser Ser Thr Asp Pro Lys Asp Ser Ser Leu Pro Gly Asp Leu His Val 
    610                 615                 620                 


Thr Ser Gly Pro Glu Ser Pro Phe Asn Asn Ile Phe Asn Asp Val Asp 
625                 630                 635                 640 


Lys Ser Glu Asp Leu Pro Ser His Gln Lys Ile Phe Asp Leu Met Glu 
                645                 650                 655     


Leu Asn Gly Val Gln Ala Asp Phe Lys Pro Ala Thr Leu Ser Ser Ser 
            660                 665                 670         


Leu Asp Asn Pro Lys Glu Ser Val Ile Thr Gly His Phe Glu Lys Glu 
        675                 680                 685             


Lys Pro Arg Lys Ile Phe Asp Ser Glu Pro Leu Cys Leu Ser Asp Asn 
    690                 695                 700                 


Leu Met His Gln Asp Asn Phe Asp Pro Leu Asn Val Gln Glu Leu Ser 
705                 710                 715                 720 


Glu Asn Phe Leu Phe Leu Gln Glu Lys Asn Leu Leu Lys Gly Ser Leu 
                725                 730                 735     


Ser Ser Lys Glu His Ile Asn Asp Leu Gln Thr Glu Leu Lys Asn Ala 
            740                 745                 750         


Gly Phe Thr Glu Ala Met Leu Glu Thr Ser Cys Arg Asn Ser Leu Asp 
        755                 760                 765             


Thr Glu Leu Gln Phe Ala Glu Asn Lys Pro Gly Leu Ser Leu Leu Gln 
    770                 775                 780                 


Glu Asn Val Ser Thr Lys Gly Asp Asp Thr Asp Val Met Leu Thr Gly 
785                 790                 795                 800 


Asp Thr Leu Ser Thr Ser Leu Gln Ser Ser Pro Glu Val Gln Val Pro 
                805                 810                 815     


Pro Thr Ser Phe Glu Thr Glu Glu Thr Pro Arg Arg Val Pro Pro Asp 
            820                 825                 830         


Ser Leu Pro Thr Gln Gly Glu Thr Gln Pro Thr Cys Leu Asp Val Ile 
        835                 840                 845             


Val Pro Glu Asp Cys Leu His Gln Asp Ile Ser Pro Asp Ala Val Thr 
    850                 855                 860                 


Val Pro Val Glu Ile Leu Ser Thr Asp Ala Arg Thr His Ser Leu Asp 
865                 870                 875                 880 


Asn Arg Ser Gln Asp Ser Pro Gly Glu Ser Glu Glu Thr Leu Arg Leu 
                885                 890                 895     


Thr Glu Ser Asp Ser Val Leu Ala Asp Asp Ile Leu Ala Ser Arg Val 
            900                 905                 910         


Ser Val Gly Ser Ser Leu Pro Glu Leu Gly Gln Glu Leu His Asn Lys 
        915                 920                 925             


Pro Phe Ser Glu Asp His His Ser His Arg Arg Leu Glu Lys Asn Leu 
    930                 935                 940                 


Glu Ala Val Glu Thr Leu Asn Gln Leu Asn Ser Lys Asp Ala Ala Lys 
945                 950                 955                 960 


Glu Ala Gly Leu Val Ser Ala Leu Ser Ser Asp Ser Thr Ser Gln Asp 
                965                 970                 975     


Ser Leu Leu Glu Asp Ser Leu Ser Ala Pro Phe Pro Ala Ser Glu Pro 
            980                 985                 990         


Ser Leu Glu Thr Pro Asp Ser Leu  Glu Ser Val Asp Val  His Glu Ala 
        995                 1000                 1005             


Leu Leu  Asp Ser Leu Gly Ser  His Thr Pro Gln Lys  Leu Val Pro 
    1010                 1015                 1020             


Pro Asp  Lys Pro Ala Asp Ser  Gly Tyr Glu Thr Glu  Asn Leu Glu 
    1025                 1030                 1035             


Ser Pro  Glu Trp Thr Leu His  Pro Ala Pro Glu Gly  Thr Ala Asp 
    1040                 1045                 1050             


Ser Glu  Pro Ala Thr Thr Gly  Asp Gly Gly His Ser  Gly Leu Pro 
    1055                 1060                 1065             


Pro Asn  Pro Val Ile Val Ile  Ser Asp Ala Gly Asp  Gly His Arg 
    1070                 1075                 1080             


Gly Thr  Glu Val Thr Pro Glu  Thr Phe Thr Ala Gly  Ser Gln Gly 
    1085                 1090                 1095             


Ser Tyr  Arg Asp Ser Ala Tyr  Phe Ser Asp Asn Asp  Ser Glu Pro 
    1100                 1105                 1110             


Glu Lys  Arg Ser Glu Glu Val  Pro Gly Thr Ser Pro  Ser Ala Leu 
    1115                 1120                 1125             


Val Leu  Val Gln Glu Gln Pro  Leu Pro Glu Pro Val  Leu Pro Glu 
    1130                 1135                 1140             


Gln Ser  Pro Ala Ala Gln Asp  Ser Cys Leu Glu Ala  Arg Lys Ser 
    1145                 1150                 1155             


Gln Pro  Asp Glu Ser Cys Leu  Ser Ala Leu His Asn  Ser Ser Asp 
    1160                 1165                 1170             


Leu Glu  Leu Arg Ala Thr Pro  Glu Pro Ala Gln Thr  Gly Val Pro 
    1175                 1180                 1185             


Gln Gln  Val His Pro Thr Glu  Asp Glu Ala Ser Ser  Pro Trp Ser 
    1190                 1195                 1200             


Val Leu  Asn Ala Glu Leu Ser  Ser Gly Asp Asp Phe  Glu Thr Gln 
    1205                 1210                 1215             


Asp Asp  Arg Pro Cys Thr Leu  Ala Ser Thr Gly Thr  Asn Thr Asn 
    1220                 1225                 1230             


Glu Leu  Leu Ala Tyr Thr Asn  Ser Ala Leu Asp Lys  Ser Leu Ser 
    1235                 1240                 1245             


Ser His  Ser Glu Gly Pro Lys  Leu Lys Glu Pro Asp  Ile Glu Gly 
    1250                 1255                 1260             


Lys Tyr  Leu Gly Lys Leu Gly  Val Ser Gly Met Leu  Asp Leu Ser 
    1265                 1270                 1275             


Glu Asp  Gly Met Asp Ala Asp  Glu Glu Asp Glu Asn  Ser Asp Asp 
    1280                 1285                 1290             


Ser Asp  Glu Asp Leu Arg Ala  Phe Asn Leu His Ser  Leu Ser Ser 
    1295                 1300                 1305             


Glu Ser  Glu Asp Glu Thr Glu  His Pro Val Pro Ile  Ile Leu Ser 
    1310                 1315                 1320             


Asn Glu  Asp Gly Arg His Leu  Arg Ser Leu Leu Lys  Pro Thr Ala 
    1325                 1330                 1335             


Ala Asn  Ala Pro Asp Pro Leu  Pro Glu Asp Trp Lys  Lys Glu Lys 
    1340                 1345                 1350             


Lys Ala  Val Thr Phe Phe Asp  Asp Val Thr Val Tyr  Leu Phe Asp 
    1355                 1360                 1365             


Gln Glu  Thr Pro Thr Lys Glu  Leu Gly Pro Cys Gly  Gly Glu Ala 
    1370                 1375                 1380             


Cys Gly  Pro Asp Leu Ser Gly  Pro Ala Pro Ala Ser  Gly Ser Pro 
    1385                 1390                 1395             


Tyr Leu  Ser Arg Cys Ile Asn  Ser Glu Ser Ser Thr  Asp Glu Glu 
    1400                 1405                 1410             


Gly Gly  Gly Phe Glu Trp Asp  Asp Asp Phe Ser Pro  Asp Pro Phe 
    1415                 1420                 1425             


Met Ser  Lys Thr Thr Ser Asn  Leu Leu Ser Ser Lys  Pro Ser Leu 
    1430                 1435                 1440             


Gln Thr  Ser Lys Tyr Phe Ser  Pro Pro Pro Pro Ala  Arg Ser Thr 
    1445                 1450                 1455             


Glu Gln  Ser Trp Pro His Ser  Ala Pro Tyr Ser Arg  Phe Ser Ile 
    1460                 1465                 1470             


Ser Pro  Ala Asn Ile Ala Ser  Phe Ser Leu Thr His  Leu Thr Asp 
    1475                 1480                 1485             


Ser Asp  Ile Glu Gln Gly Gly  Ser Ser Glu Asp Gly  Glu Lys Asp 
    1490                 1495                 1500             


<210>  4012
<211>  802
<212>  PRT
<213>  Homo sapiens

<400>  4012

Met Ala Ala Arg Gly Arg Arg Ala Trp Leu Ser Val Leu Leu Gly Leu 
1               5                   10                  15      


Val Leu Gly Phe Val Leu Ala Ser Arg Leu Val Leu Pro Arg Ala Ser 
            20                  25                  30          


Glu Leu Lys Arg Ala Gly Pro Arg Arg Arg Ala Ser Pro Glu Gly Cys 
        35                  40                  45              


Arg Ser Gly Gln Ala Ala Ala Ser Gln Ala Gly Gly Ala Arg Gly Asp 
    50                  55                  60                  


Ala Arg Gly Ala Gln Leu Trp Pro Pro Gly Ser Asp Pro Asp Gly Gly 
65                  70                  75                  80  


Pro Arg Asp Arg Asn Phe Leu Phe Val Gly Val Met Thr Ala Gln Lys 
                85                  90                  95      


Tyr Leu Gln Thr Arg Ala Val Ala Ala Tyr Arg Thr Trp Ser Lys Thr 
            100                 105                 110         


Ile Pro Gly Lys Val Gln Phe Phe Ser Ser Glu Gly Ser Asp Thr Ser 
        115                 120                 125             


Val Pro Ile Pro Val Val Pro Leu Arg Gly Val Asp Asp Ser Tyr Pro 
    130                 135                 140                 


Pro Gln Lys Lys Ser Phe Met Met Leu Lys Tyr Met His Asp His Tyr 
145                 150                 155                 160 


Leu Asp Lys Tyr Glu Trp Phe Met Arg Ala Asp Asp Asp Val Tyr Ile 
                165                 170                 175     


Lys Gly Asp Arg Leu Glu Asn Phe Leu Arg Ser Leu Asn Ser Ser Glu 
            180                 185                 190         


Pro Leu Phe Leu Gly Gln Thr Gly Leu Gly Thr Thr Glu Glu Met Gly 
        195                 200                 205             


Lys Leu Ala Leu Glu Pro Gly Glu Asn Phe Cys Met Gly Gly Pro Gly 
    210                 215                 220                 


Val Ile Met Ser Arg Glu Val Leu Arg Arg Met Val Pro His Ile Gly 
225                 230                 235                 240 


Lys Cys Leu Arg Glu Met Tyr Thr Thr His Glu Asp Val Glu Val Gly 
                245                 250                 255     


Arg Cys Val Arg Arg Phe Ala Gly Val Gln Cys Val Trp Ser Tyr Glu 
            260                 265                 270         


Met Gln Gln Leu Phe Tyr Glu Asn Tyr Glu Gln Asn Lys Lys Gly Tyr 
        275                 280                 285             


Ile Arg Asp Leu His Asn Ser Lys Ile His Gln Ala Ile Thr Leu His 
    290                 295                 300                 


Pro Asn Lys Asn Pro Pro Tyr Gln Tyr Arg Leu His Ser Tyr Met Leu 
305                 310                 315                 320 


Ser Arg Lys Ile Ser Glu Leu Arg His Arg Thr Ile Gln Leu His Arg 
                325                 330                 335     


Glu Ile Val Leu Met Ser Lys Tyr Ser Asn Thr Glu Ile His Lys Glu 
            340                 345                 350         


Asp Leu Gln Leu Gly Ile Pro Pro Ser Phe Met Arg Phe Gln Pro Arg 
        355                 360                 365             


Gln Arg Glu Glu Ile Leu Glu Trp Glu Phe Leu Thr Gly Lys Tyr Leu 
    370                 375                 380                 


Tyr Ser Ala Val Asp Gly Gln Pro Pro Arg Arg Gly Met Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Glu Ala Leu Asp Asp Ile Val Met Gln Val Met Glu Met Ile 
                405                 410                 415     


Asn Ala Asn Ala Lys Thr Arg Gly Arg Ile Ile Asp Phe Lys Glu Ile 
            420                 425                 430         


Gln Tyr Gly Tyr Arg Arg Val Asn Pro Met Tyr Gly Ala Glu Tyr Ile 
        435                 440                 445             


Leu Asp Leu Leu Leu Leu Tyr Lys Lys His Lys Gly Lys Lys Met Thr 
    450                 455                 460                 


Val Pro Val Arg Arg His Ala Tyr Leu Gln Gln Thr Phe Ser Lys Ile 
465                 470                 475                 480 


Gln Phe Val Glu His Glu Glu Leu Asp Ala Gln Glu Leu Ala Lys Arg 
                485                 490                 495     


Ile Asn Gln Glu Ser Gly Ser Leu Ser Phe Leu Ser Asn Ser Leu Lys 
            500                 505                 510         


Lys Leu Val Pro Phe Gln Leu Pro Gly Ser Lys Ser Glu His Lys Glu 
        515                 520                 525             


Pro Lys Asp Lys Lys Ile Asn Ile Leu Ile Pro Leu Ser Gly Arg Phe 
    530                 535                 540                 


Asp Met Phe Val Arg Phe Met Gly Asn Phe Glu Lys Thr Cys Leu Ile 
545                 550                 555                 560 


Pro Asn Gln Asn Val Lys Leu Val Val Leu Leu Phe Asn Ser Asp Ser 
                565                 570                 575     


Asn Pro Asp Lys Ala Lys Gln Val Glu Leu Met Arg Asp Tyr Arg Ile 
            580                 585                 590         


Lys Tyr Pro Lys Ala Asp Met Gln Ile Leu Pro Val Ser Gly Glu Phe 
        595                 600                 605             


Ser Arg Ala Leu Ala Leu Glu Val Gly Ser Ser Gln Phe Asn Asn Glu 
    610                 615                 620                 


Ser Leu Leu Phe Phe Cys Asp Val Asp Leu Val Phe Thr Thr Glu Phe 
625                 630                 635                 640 


Leu Gln Arg Cys Arg Ala Asn Thr Val Leu Gly Gln Gln Ile Tyr Phe 
                645                 650                 655     


Pro Ile Ile Phe Ser Gln Tyr Asp Pro Lys Ile Val Tyr Ser Gly Lys 
            660                 665                 670         


Val Pro Ser Asp Asn His Phe Ala Phe Thr Gln Lys Thr Gly Phe Trp 
        675                 680                 685             


Arg Asn Tyr Gly Phe Gly Ile Thr Cys Ile Tyr Lys Gly Asp Leu Val 
    690                 695                 700                 


Arg Val Gly Gly Phe Asp Val Ser Ile Gln Gly Trp Gly Leu Glu Asp 
705                 710                 715                 720 


Val Asp Leu Phe Asn Lys Val Val Gln Ala Gly Leu Lys Thr Phe Arg 
                725                 730                 735     


Ser Gln Glu Val Gly Val Val His Val His His Pro Val Phe Cys Asp 
            740                 745                 750         


Pro Asn Leu Asp Pro Lys Gln Tyr Lys Met Cys Leu Gly Ser Lys Ala 
        755                 760                 765             


Ser Thr Tyr Gly Ser Thr Gln Gln Leu Ala Glu Met Trp Leu Glu Lys 
    770                 775                 780                 


Asn Asp Pro Ser Tyr Ser Lys Ser Ser Asn Asn Asn Gly Ser Val Arg 
785                 790                 795                 800 


Thr Ala 
        


<210>  4013
<211>  1469
<212>  PRT
<213>  Homo sapiens

<400>  4013

Met Ala Arg Leu Ala Ala Val Leu Trp Asn Leu Cys Val Thr Ala Val 
1               5                   10                  15      


Leu Val Thr Ser Ala Thr Gln Gly Leu Ser Arg Ala Gly Leu Pro Phe 
            20                  25                  30          


Gly Leu Met Arg Arg Glu Leu Ala Cys Glu Gly Tyr Pro Ile Glu Leu 
        35                  40                  45              


Arg Cys Pro Gly Ser Asp Val Ile Met Val Glu Asn Ala Asn Tyr Gly 
    50                  55                  60                  


Arg Thr Asp Asp Lys Ile Cys Asp Ala Asp Pro Phe Gln Met Glu Asn 
65                  70                  75                  80  


Val Gln Cys Tyr Leu Pro Asp Ala Phe Lys Ile Met Ser Gln Arg Cys 
                85                  90                  95      


Asn Asn Arg Thr Gln Cys Val Val Val Ala Gly Ser Asp Ala Phe Pro 
            100                 105                 110         


Asp Pro Cys Pro Gly Thr Tyr Lys Tyr Leu Glu Val Gln Tyr Asp Cys 
        115                 120                 125             


Val Pro Tyr Ile Phe Val Cys Pro Gly Thr Leu Gln Lys Val Leu Glu 
    130                 135                 140                 


Pro Thr Ser Thr His Glu Ser Glu His Gln Ser Gly Ala Trp Cys Lys 
145                 150                 155                 160 


Asp Pro Leu Gln Ala Gly Asp Arg Ile Tyr Val Met Pro Trp Ile Pro 
                165                 170                 175     


Tyr Arg Thr Asp Thr Leu Thr Glu Tyr Ala Ser Trp Glu Asp Tyr Val 
            180                 185                 190         


Ala Ala Arg His Thr Thr Thr Tyr Arg Leu Pro Asn Arg Val Asp Gly 
        195                 200                 205             


Thr Gly Phe Val Val Tyr Asp Gly Ala Val Phe Tyr Asn Lys Glu Arg 
    210                 215                 220                 


Thr Arg Asn Ile Val Lys Tyr Asp Leu Arg Thr Arg Ile Lys Ser Gly 
225                 230                 235                 240 


Glu Thr Val Ile Asn Thr Ala Asn Tyr His Asp Thr Ser Pro Tyr Arg 
                245                 250                 255     


Trp Gly Gly Lys Thr Asp Ile Asp Leu Ala Val Asp Glu Asn Gly Leu 
            260                 265                 270         


Trp Val Ile Tyr Ala Thr Glu Gly Asn Asn Gly Arg Leu Val Val Ser 
        275                 280                 285             


Gln Leu Asn Pro Tyr Thr Leu Arg Phe Glu Gly Thr Trp Glu Thr Gly 
    290                 295                 300                 


Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met Val Cys Gly Val Leu 
305                 310                 315                 320 


Tyr Val Leu Arg Ser Val Tyr Val Asp Asp Asp Ser Glu Ala Ala Gly 
                325                 330                 335     


Asn Arg Val Asp Tyr Ala Phe Asn Thr Asn Ala Asn Arg Glu Glu Pro 
            340                 345                 350         


Val Ser Leu Thr Phe Pro Asn Pro Tyr Gln Phe Ile Ser Ser Val Asp 
        355                 360                 365             


Tyr Asn Pro Arg Asp Asn Gln Leu Tyr Val Trp Asn Asn Tyr Phe Val 
    370                 375                 380                 


Val Arg Tyr Ser Leu Glu Phe Gly Pro Pro Asp Pro Ser Ala Gly Pro 
385                 390                 395                 400 


Ala Thr Ser Pro Pro Leu Ser Thr Thr Thr Thr Ala Arg Pro Thr Pro 
                405                 410                 415     


Leu Thr Ser Thr Ala Ser Pro Ala Ala Thr Thr Pro Leu Arg Arg Ala 
            420                 425                 430         


Pro Leu Thr Thr His Pro Val Gly Ala Ile Asn Gln Leu Gly Pro Asp 
        435                 440                 445             


Leu Pro Pro Ala Thr Ala Pro Val Pro Ser Thr Arg Arg Pro Pro Ala 
    450                 455                 460                 


Pro Asn Leu His Val Ser Pro Glu Leu Phe Cys Glu Pro Arg Glu Val 
465                 470                 475                 480 


Arg Arg Val Gln Trp Pro Ala Thr Gln Gln Gly Met Leu Val Glu Arg 
                485                 490                 495     


Pro Cys Pro Lys Gly Thr Arg Gly Ile Ala Ser Phe Gln Cys Leu Pro 
            500                 505                 510         


Ala Leu Gly Leu Trp Asn Pro Arg Gly Pro Asp Leu Ser Asn Cys Thr 
        515                 520                 525             


Ser Pro Trp Val Asn Gln Val Ala Gln Lys Ile Lys Ser Gly Glu Asn 
    530                 535                 540                 


Ala Ala Asn Ile Ala Ser Glu Leu Ala Arg His Thr Arg Gly Ser Ile 
545                 550                 555                 560 


Tyr Ala Gly Asp Val Ser Ser Ser Val Lys Leu Met Glu Gln Leu Leu 
                565                 570                 575     


Asp Ile Leu Asp Ala Gln Leu Gln Ala Leu Arg Pro Ile Glu Arg Glu 
            580                 585                 590         


Ser Ala Gly Lys Asn Tyr Asn Lys Met His Lys Arg Glu Arg Thr Cys 
        595                 600                 605             


Lys Asp Tyr Ile Lys Ala Val Val Glu Thr Val Asp Asn Leu Leu Arg 
    610                 615                 620                 


Pro Glu Ala Leu Glu Ser Trp Lys Asp Met Asn Ala Thr Glu Gln Val 
625                 630                 635                 640 


His Thr Ala Thr Met Leu Leu Asp Val Leu Glu Glu Gly Ala Phe Leu 
                645                 650                 655     


Leu Ala Asp Asn Val Arg Glu Pro Ala Arg Phe Leu Ala Ala Lys Glu 
            660                 665                 670         


Asn Val Val Leu Glu Val Thr Val Leu Asn Thr Glu Gly Gln Val Gln 
        675                 680                 685             


Glu Leu Val Phe Pro Gln Glu Glu Tyr Pro Arg Lys Asn Ser Ile Gln 
    690                 695                 700                 


Leu Ser Ala Lys Thr Ile Lys Gln Asn Ser Arg Asn Gly Val Val Lys 
705                 710                 715                 720 


Val Val Phe Ile Leu Tyr Asn Asn Leu Gly Leu Phe Leu Ser Thr Glu 
                725                 730                 735     


Asn Ala Thr Val Lys Leu Ala Gly Glu Ala Gly Pro Gly Gly Pro Gly 
            740                 745                 750         


Gly Ala Ser Leu Val Val Asn Ser Gln Val Ile Ala Ala Ser Ile Asn 
        755                 760                 765             


Lys Glu Ser Ser Arg Val Phe Leu Met Asp Pro Val Ile Phe Thr Val 
    770                 775                 780                 


Ala His Leu Glu Asp Lys Asn His Phe Asn Ala Asn Cys Ser Phe Trp 
785                 790                 795                 800 


Asn Tyr Ser Glu Arg Ser Met Leu Gly Tyr Trp Ser Thr Gln Gly Cys 
                805                 810                 815     


Arg Leu Val Glu Ser Asn Lys Thr His Thr Thr Cys Ala Cys Ser His 
            820                 825                 830         


Leu Thr Asn Phe Ala Val Leu Met Ala His Arg Glu Ile Tyr Gln Gly 
        835                 840                 845             


Arg Ile Asn Glu Leu Leu Leu Ser Val Ile Thr Trp Val Gly Ile Val 
    850                 855                 860                 


Ile Ser Leu Val Cys Leu Ala Ile Cys Ile Ser Thr Phe Cys Phe Leu 
865                 870                 875                 880 


Arg Gly Leu Gln Thr Asp Arg Asn Thr Ile His Lys Asn Leu Cys Ile 
                885                 890                 895     


Asn Leu Phe Leu Ala Glu Leu Leu Phe Leu Val Gly Ile Asp Lys Thr 
            900                 905                 910         


Gln Tyr Glu Ile Ala Cys Pro Ile Phe Ala Gly Leu Leu His Tyr Phe 
        915                 920                 925             


Phe Leu Ala Ala Phe Ser Trp Leu Cys Leu Glu Gly Val His Leu Tyr 
    930                 935                 940                 


Leu Leu Leu Val Glu Val Phe Glu Ser Glu Tyr Ser Arg Thr Lys Tyr 
945                 950                 955                 960 


Tyr Tyr Leu Gly Gly Tyr Cys Phe Pro Ala Leu Val Val Gly Ile Ala 
                965                 970                 975     


Ala Ala Ile Asp Tyr Arg Ser Tyr Gly Thr Glu Lys Ala Cys Trp Leu 
            980                 985                 990         


Arg Val Asp Asn Tyr Phe Ile Trp  Ser Phe Ile Gly Pro  Val Ser Phe 
        995                 1000                 1005             


Val Ile  Val Val Asn Leu Val  Phe Leu Met Val Thr  Leu His Lys 
    1010                 1015                 1020             


Met Ile  Arg Ser Ser Ser Val  Leu Lys Pro Asp Ser  Ser Arg Leu 
    1025                 1030                 1035             


Asp Asn  Ile Lys Ser Trp Ala  Leu Gly Ala Ile Ala  Leu Leu Phe 
    1040                 1045                 1050             


Leu Leu  Gly Leu Thr Trp Ala  Phe Gly Leu Leu Phe  Ile Asn Lys 
    1055                 1060                 1065             


Glu Ser  Val Val Met Ala Tyr  Leu Phe Thr Thr Phe  Asn Ala Phe 
    1070                 1075                 1080             


Gln Gly  Val Phe Ile Phe Val  Phe His Cys Ala Leu  Gln Lys Lys 
    1085                 1090                 1095             


Val His  Lys Glu Tyr Ser Lys  Cys Leu Arg His Ser  Tyr Cys Cys 
    1100                 1105                 1110             


Ile Arg  Ser Pro Pro Gly Gly  Thr His Gly Ser Leu  Lys Thr Ser 
    1115                 1120                 1125             


Ala Met  Arg Ser Asn Thr Arg  Tyr Tyr Thr Gly Thr  Gln Ser Arg 
    1130                 1135                 1140             


Ile Arg  Arg Met Trp Asn Asp  Thr Val Arg Lys Gln  Thr Glu Ser 
    1145                 1150                 1155             


Ser Phe  Met Ala Gly Asp Ile  Asn Ser Thr Pro Thr  Leu Asn Arg 
    1160                 1165                 1170             


Gly Thr  Met Gly Asn His Leu  Leu Thr Asn Pro Val  Leu Gln Pro 
    1175                 1180                 1185             


Arg Gly  Gly Thr Ser Pro Tyr  Asn Thr Leu Ile Ala  Glu Ser Val 
    1190                 1195                 1200             


Gly Phe  Asn Pro Ser Ser Pro  Pro Val Phe Asn Ser  Pro Gly Ser 
    1205                 1210                 1215             


Tyr Arg  Glu Pro Lys His Pro  Leu Gly Gly Arg Glu  Ala Cys Gly 
    1220                 1225                 1230             


Met Asp  Thr Leu Pro Leu Asn  Gly Asn Phe Asn Asn  Ser Tyr Ser 
    1235                 1240                 1245             


Leu Arg  Ser Gly Asp Phe Pro  Pro Gly Asp Gly Gly  Pro Glu Pro 
    1250                 1255                 1260             


Pro Arg  Gly Arg Asn Leu Ala  Asp Ala Ala Ala Phe  Glu Lys Met 
    1265                 1270                 1275             


Ile Ile  Ser Glu Leu Val His  Asn Asn Leu Arg Gly  Ser Ser Ser 
    1280                 1285                 1290             


Ala Ala  Lys Gly Pro Pro Pro  Pro Glu Pro Pro Val  Pro Pro Val 
    1295                 1300                 1305             


Pro Gly  Gly Gly Gly Glu Glu  Glu Ala Gly Gly Pro  Gly Gly Ala 
    1310                 1315                 1320             


Asp Arg  Ala Glu Ile Glu Leu  Leu Tyr Lys Ala Leu  Glu Glu Pro 
    1325                 1330                 1335             


Leu Leu  Leu Pro Arg Ala Gln  Ser Val Leu Tyr Gln  Ser Asp Leu 
    1340                 1345                 1350             


Asp Glu  Ser Glu Ser Cys Thr  Ala Glu Asp Gly Ala  Thr Ser Arg 
    1355                 1360                 1365             


Pro Leu  Ser Ser Pro Pro Gly  Arg Asp Ser Leu Tyr  Ala Ser Gly 
    1370                 1375                 1380             


Ala Asn  Leu Arg Asp Ser Pro  Ser Tyr Pro Asp Ser  Ser Pro Glu 
    1385                 1390                 1395             


Gly Pro  Ser Glu Ala Leu Pro  Pro Pro Pro Pro Ala  Pro Pro Gly 
    1400                 1405                 1410             


Pro Pro  Glu Ile Tyr Tyr Thr  Ser Arg Pro Pro Ala  Leu Val Ala 
    1415                 1420                 1425             


Arg Asn  Pro Leu Gln Gly Tyr  Tyr Gln Val Arg Arg  Pro Ser His 
    1430                 1435                 1440             


Glu Gly  Tyr Leu Ala Ala Pro  Gly Leu Glu Gly Pro  Gly Pro Asp 
    1445                 1450                 1455             


Gly Asp  Gly Gln Met Gln Leu  Val Thr Ser Leu 
    1460                 1465                 


<210>  4014
<211>  1142
<212>  PRT
<213>  Homo sapiens

<400>  4014

Met Ser Gly Pro Ala Gln Val Pro Met Met Ser Pro Asn Gly Ser Val 
1               5                   10                  15      


Pro Pro Ile Tyr Val Pro Pro Gly Tyr Ala Pro Gln Val Ile Glu Asp 
            20                  25                  30          


Asn Gly Val Arg Arg Val Val Val Val Pro Gln Ala Pro Glu Phe His 
        35                  40                  45              


Pro Gly Ser His Thr Val Leu His Arg Ser Pro His Pro Pro Leu Pro 
    50                  55                  60                  


Gly Phe Ile Pro Val Pro Thr Met Met Pro Pro Pro Pro Arg His Met 
65                  70                  75                  80  


Tyr Ser Pro Val Thr Gly Ala Gly Asp Met Thr Thr Gln Tyr Met Pro 
                85                  90                  95      


Gln Tyr Gln Ser Ser Gln Val Tyr Gly Asp Val Asp Ala His Ser Thr 
            100                 105                 110         


His Gly Arg Ser Asn Phe Arg Asp Glu Arg Ser Ser Lys Thr Tyr Glu 
        115                 120                 125             


Arg Leu Gln Lys Lys Leu Lys Asp Arg Gln Gly Thr Gln Lys Asp Lys 
    130                 135                 140                 


Met Ser Ser Pro Pro Ser Ser Pro Gln Lys Cys Pro Ser Pro Ile Asn 
145                 150                 155                 160 


Glu His Asn Gly Leu Ile Lys Gly Gln Ile Ala Gly Gly Ile Asn Thr 
                165                 170                 175     


Gly Ser Ala Lys Ile Lys Ser Gly Lys Gly Lys Gly Gly Thr Gln Val 
            180                 185                 190         


Asp Thr Glu Ile Glu Glu Lys Asp Glu Glu Thr Lys Ala Phe Glu Ala 
        195                 200                 205             


Leu Leu Ser Asn Ile Val Lys Pro Val Ala Ser Asp Ile Gln Ala Arg 
    210                 215                 220                 


Thr Val Val Leu Thr Trp Ser Pro Pro Ser Ser Leu Ile Asn Gly Glu 
225                 230                 235                 240 


Thr Asp Glu Ser Ser Val Pro Glu Leu Tyr Gly Tyr Glu Val Leu Ile 
                245                 250                 255     


Ser Ser Thr Gly Lys Asp Gly Lys Tyr Lys Ser Val Tyr Val Gly Glu 
            260                 265                 270         


Glu Thr Asn Ile Thr Leu Asn Asp Leu Lys Pro Ala Met Asp Tyr His 
        275                 280                 285             


Ala Lys Val Gln Ala Glu Tyr Asn Ser Ile Lys Gly Thr Pro Ser Glu 
    290                 295                 300                 


Ala Glu Ile Phe Thr Thr Leu Ser Cys Glu Pro Asp Ile Pro Asn Pro 
305                 310                 315                 320 


Pro Arg Ile Ala Asn Arg Thr Lys Asn Ser Leu Thr Leu Gln Trp Lys 
                325                 330                 335     


Ala Pro Ser Asp Asn Gly Ser Lys Ile Gln Asn Phe Val Leu Glu Trp 
            340                 345                 350         


Asp Glu Gly Lys Gly Asn Gly Glu Phe Cys Gln Cys Tyr Met Gly Ser 
        355                 360                 365             


Gln Lys Gln Phe Lys Ile Thr Lys Leu Ser Pro Ala Met Gly Cys Lys 
    370                 375                 380                 


Phe Arg Leu Ser Ala Arg Asn Asp Tyr Gly Thr Ser Gly Phe Ser Glu 
385                 390                 395                 400 


Glu Val Leu Tyr Tyr Thr Ser Gly Cys Ala Pro Ser Met Pro Ala Ser 
                405                 410                 415     


Pro Val Leu Thr Lys Ala Gly Ile Thr Trp Leu Ser Leu Gln Trp Ser 
            420                 425                 430         


Lys Pro Ser Gly Thr Pro Ser Asp Glu Gly Ile Ser Tyr Ile Leu Glu 
        435                 440                 445             


Met Glu Glu Glu Thr Ser Gly Tyr Gly Phe Lys Pro Lys Tyr Asp Gly 
    450                 455                 460                 


Glu Asp Leu Ala Tyr Thr Val Lys Asn Leu Arg Arg Ser Thr Lys Tyr 
465                 470                 475                 480 


Lys Phe Lys Val Ile Ala Tyr Asn Ser Glu Gly Lys Ser Asn Pro Ser 
                485                 490                 495     


Glu Val Val Glu Phe Thr Thr Cys Pro Asp Lys Pro Gly Ile Pro Val 
            500                 505                 510         


Lys Pro Ser Val Lys Gly Lys Ile His Ser His Ser Phe Lys Ile Thr 
        515                 520                 525             


Trp Asp Pro Pro Lys Asp Asn Gly Gly Ala Thr Ile Asn Lys Tyr Val 
    530                 535                 540                 


Val Glu Met Ala Glu Gly Ser Asn Gly Asn Lys Trp Glu Met Ile Tyr 
545                 550                 555                 560 


Ser Gly Ala Thr Arg Glu His Leu Cys Asp Arg Leu Asn Pro Gly Cys 
                565                 570                 575     


Phe Tyr Arg Leu Arg Val Tyr Cys Ile Ser Asp Gly Gly Gln Ser Ala 
            580                 585                 590         


Val Ser Glu Ser Leu Leu Val Gln Thr Pro Ala Val Pro Pro Gly Pro 
        595                 600                 605             


Cys Leu Pro Pro Arg Leu Gln Gly Arg Pro Lys Ala Lys Glu Ile Gln 
    610                 615                 620                 


Leu Arg Trp Gly Pro Pro Leu Val Asp Gly Gly Ser Pro Ile Ser Cys 
625                 630                 635                 640 


Tyr Ser Val Glu Met Ser Pro Ile Glu Lys Asp Glu Pro Arg Glu Val 
                645                 650                 655     


Tyr Gln Gly Ser Glu Val Glu Cys Thr Val Ser Ser Leu Leu Pro Gly 
            660                 665                 670         


Lys Thr Tyr Ser Phe Arg Leu Arg Ala Ala Asn Lys Met Gly Phe Gly 
        675                 680                 685             


Pro Phe Ser Glu Lys Cys Asp Ile Thr Thr Ala Pro Gly Pro Pro Asp 
    690                 695                 700                 


Gln Cys Lys Pro Pro Gln Val Thr Cys Arg Ser Ala Thr Cys Ala Gln 
705                 710                 715                 720 


Val Asn Trp Glu Val Pro Leu Ser Asn Gly Thr Asp Val Thr Glu Tyr 
                725                 730                 735     


Arg Leu Glu Trp Gly Gly Val Glu Gly Ser Met Gln Ile Cys Tyr Cys 
            740                 745                 750         


Gly Pro Gly Leu Ser Tyr Glu Ile Lys Gly Leu Ser Pro Ala Thr Thr 
        755                 760                 765             


Tyr Tyr Cys Arg Val Gln Ala Leu Ser Val Val Gly Ala Gly Pro Phe 
    770                 775                 780                 


Ser Glu Val Val Ala Cys Val Thr Pro Pro Ser Val Pro Gly Ile Val 
785                 790                 795                 800 


Thr Cys Leu Gln Glu Ile Ser Asp Asp Glu Ile Glu Asn Pro His Tyr 
                805                 810                 815     


Ser Pro Ser Thr Cys Leu Ala Ile Ser Trp Glu Lys Pro Cys Asp His 
            820                 825                 830         


Gly Ser Glu Ile Leu Ala Tyr Ser Ile Asp Phe Gly Asp Lys Gln Ser 
        835                 840                 845             


Leu Thr Val Gly Lys Val Thr Ser Tyr Ile Ile Asn Asn Leu Gln Pro 
    850                 855                 860                 


Asp Thr Thr Tyr Arg Ile Arg Ile Gln Ala Leu Asn Ser Leu Gly Ala 
865                 870                 875                 880 


Gly Pro Phe Ser His Met Ile Lys Leu Lys Thr Lys Pro Leu Pro Pro 
                885                 890                 895     


Asp Pro Pro Arg Leu Glu Cys Val Ala Phe Ser His Gln Asn Leu Lys 
            900                 905                 910         


Leu Lys Trp Gly Glu Gly Thr Pro Lys Thr Leu Ser Thr Asp Ser Ile 
        915                 920                 925             


Gln Tyr His Leu Gln Met Glu Asp Lys Asn Gly Arg Phe Val Ser Leu 
    930                 935                 940                 


Tyr Arg Gly Pro Cys His Thr Tyr Lys Val Gln Arg Leu Asn Glu Ser 
945                 950                 955                 960 


Thr Ser Tyr Lys Phe Cys Ile Gln Ala Cys Asn Glu Ala Gly Glu Gly 
                965                 970                 975     


Pro Leu Ser Gln Glu Tyr Ile Phe Thr Thr Pro Lys Ser Val Pro Ala 
            980                 985                 990         


Ala Leu Lys Ala Pro Lys Ile Glu  Lys Val Asn Asp His  Ile Cys Glu 
        995                 1000                 1005             


Ile Thr  Trp Glu Cys Leu Gln  Pro Met Lys Gly Asp  Pro Val Ile 
    1010                 1015                 1020             


Tyr Ser  Leu Gln Val Met Leu  Gly Lys Asp Ser Glu  Phe Lys Gln 
    1025                 1030                 1035             


Ile Tyr  Lys Gly Pro Asp Ser  Ser Phe Arg Tyr Ser  Ser Leu Gln 
    1040                 1045                 1050             


Leu Asn  Cys Glu Tyr Arg Phe  Arg Val Cys Ala Ile  Arg Gln Cys 
    1055                 1060                 1065             


Gln Asp  Ser Leu Gly His Gln  Asp Leu Val Gly Pro  Tyr Ser Thr 
    1070                 1075                 1080             


Thr Val  Leu Phe Ile Ser Gln  Arg Thr Glu Pro Pro  Ala Ser Thr 
    1085                 1090                 1095             


Asn Arg  Asp Thr Val Glu Ser  Thr Arg Thr Arg Arg  Ala Leu Ser 
    1100                 1105                 1110             


Asp Glu  Gln Cys Ala Ala Val  Ile Leu Val Leu Phe  Ala Phe Phe 
    1115                 1120                 1125             


Ser Ile  Leu Ile Ala Phe Ile  Ile Gln Tyr Phe Val  Ile Lys 
    1130                 1135                 1140         


<210>  4015
<211>  977
<212>  PRT
<213>  Homo sapiens

<400>  4015

Met Lys Pro Ser Ile Ala Glu Met Leu His Arg Gly Arg Met Leu Trp 
1               5                   10                  15      


Ile Ile Leu Leu Ser Thr Ile Ala Leu Gly Trp Thr Thr Pro Ile Pro 
            20                  25                  30          


Leu Ile Glu Asp Ser Glu Glu Ile Asp Glu Pro Cys Phe Asp Pro Cys 
        35                  40                  45              


Tyr Cys Glu Val Lys Glu Ser Leu Phe His Ile His Cys Asp Ser Lys 
    50                  55                  60                  


Gly Phe Thr Asn Ile Ser Gln Ile Thr Glu Phe Trp Ser Arg Pro Phe 
65                  70                  75                  80  


Lys Leu Tyr Leu Gln Arg Asn Ser Met Arg Lys Leu Tyr Thr Asn Ser 
                85                  90                  95      


Phe Leu His Leu Asn Asn Ala Val Ser Ile Asn Leu Gly Asn Asn Ala 
            100                 105                 110         


Leu Gln Asp Ile Gln Thr Gly Ala Phe Asn Gly Leu Lys Ile Leu Lys 
        115                 120                 125             


Arg Leu Tyr Leu His Glu Asn Lys Leu Asp Val Phe Arg Asn Asp Thr 
    130                 135                 140                 


Phe Leu Gly Leu Glu Ser Leu Glu Tyr Leu Gln Ala Asp Tyr Asn Val 
145                 150                 155                 160 


Ile Lys Arg Ile Glu Ser Gly Ala Phe Arg Asn Leu Ser Lys Leu Arg 
                165                 170                 175     


Val Leu Ile Leu Asn Asp Asn Leu Ile Pro Met Leu Pro Thr Asn Leu 
            180                 185                 190         


Phe Lys Ala Val Ser Leu Thr His Leu Asp Leu Arg Gly Asn Arg Leu 
        195                 200                 205             


Lys Val Leu Phe Tyr Arg Gly Met Leu Asp His Ile Gly Arg Ser Leu 
    210                 215                 220                 


Met Glu Leu Gln Leu Glu Glu Asn Pro Trp Asn Cys Thr Cys Glu Ile 
225                 230                 235                 240 


Val Gln Leu Lys Ser Trp Leu Glu Arg Ile Pro Tyr Thr Ala Leu Val 
                245                 250                 255     


Gly Asp Ile Thr Cys Glu Thr Pro Phe His Phe His Gly Lys Asp Leu 
            260                 265                 270         


Arg Glu Ile Arg Lys Thr Glu Leu Cys Pro Leu Leu Ser Asp Ser Glu 
        275                 280                 285             


Val Glu Ala Ser Leu Gly Ile Pro His Ser Ser Ser Ser Lys Glu Asn 
    290                 295                 300                 


Ala Trp Pro Thr Lys Pro Ser Ser Met Leu Ser Ser Val His Phe Thr 
305                 310                 315                 320 


Ala Ser Ser Val Glu Tyr Lys Ser Ser Asn Lys Gln Pro Lys Pro Thr 
                325                 330                 335     


Lys Gln Pro Arg Thr Pro Arg Pro Pro Ser Thr Ser Gln Ala Leu Tyr 
            340                 345                 350         


Pro Gly Pro Asn Gln Pro Pro Ile Ala Pro Tyr Gln Thr Arg Pro Pro 
        355                 360                 365             


Ile Pro Ile Ile Cys Pro Thr Gly Cys Thr Cys Asn Leu His Ile Asn 
    370                 375                 380                 


Asp Leu Gly Leu Thr Val Asn Cys Lys Glu Arg Gly Phe Asn Asn Ile 
385                 390                 395                 400 


Ser Glu Leu Leu Pro Arg Pro Leu Asn Ala Lys Lys Leu Tyr Leu Ser 
                405                 410                 415     


Ser Asn Leu Ile Gln Lys Ile Tyr Arg Ser Asp Phe Trp Asn Phe Ser 
            420                 425                 430         


Ser Leu Asp Leu Leu His Leu Gly Asn Asn Arg Ile Ser Tyr Val Gln 
        435                 440                 445             


Asp Gly Ala Phe Ile Asn Leu Pro Asn Leu Lys Ser Leu Phe Leu Asn 
    450                 455                 460                 


Gly Asn Asp Ile Glu Lys Leu Thr Pro Gly Met Phe Arg Gly Leu Gln 
465                 470                 475                 480 


Ser Leu His Tyr Leu Tyr Phe Glu Phe Asn Val Ile Arg Glu Ile Gln 
                485                 490                 495     


Pro Ala Ala Phe Ser Leu Met Pro Asn Leu Lys Leu Leu Phe Leu Asn 
            500                 505                 510         


Asn Asn Leu Leu Arg Thr Leu Pro Thr Asp Ala Phe Ala Gly Thr Ser 
        515                 520                 525             


Leu Ala Arg Leu Asn Leu Arg Lys Asn Tyr Phe Leu Tyr Leu Pro Val 
    530                 535                 540                 


Ala Gly Val Leu Glu His Leu Asn Ala Ile Val Gln Ile Asp Leu Asn 
545                 550                 555                 560 


Glu Asn Pro Trp Asp Cys Thr Cys Asp Leu Val Pro Phe Lys Gln Trp 
                565                 570                 575     


Ile Glu Thr Ile Ser Ser Val Ser Val Val Gly Asp Val Leu Cys Arg 
            580                 585                 590         


Ser Pro Glu Asn Leu Thr His Arg Asp Val Arg Thr Ile Glu Leu Glu 
        595                 600                 605             


Val Leu Cys Pro Glu Met Leu His Val Ala Pro Ala Gly Glu Ser Pro 
    610                 615                 620                 


Ala Gln Pro Gly Asp Ser His Leu Ile Gly Ala Pro Thr Ser Ala Ser 
625                 630                 635                 640 


Pro Tyr Glu Phe Ser Pro Pro Gly Gly Pro Val Pro Leu Ser Val Leu 
                645                 650                 655     


Ile Leu Ser Leu Leu Val Leu Phe Phe Ser Ala Val Phe Val Ala Ala 
            660                 665                 670         


Gly Leu Phe Ala Tyr Val Leu Arg Arg Arg Arg Lys Lys Leu Pro Phe 
        675                 680                 685             


Arg Ser Lys Arg Gln Glu Gly Val Asp Leu Thr Gly Ile Gln Met Gln 
    690                 695                 700                 


Cys His Arg Leu Phe Glu Asp Gly Gly Gly Gly Gly Gly Gly Ser Gly 
705                 710                 715                 720 


Gly Gly Gly Arg Pro Thr Leu Ser Ser Pro Glu Lys Ala Pro Pro Val 
                725                 730                 735     


Gly His Val Tyr Glu Tyr Ile Pro His Pro Val Thr Gln Met Cys Asn 
            740                 745                 750         


Asn Pro Ile Tyr Lys Pro Arg Glu Glu Glu Glu Val Ala Val Ser Ser 
        755                 760                 765             


Ala Gln Glu Ala Gly Ser Ala Glu Arg Gly Gly Pro Gly Thr Gln Pro 
    770                 775                 780                 


Pro Gly Met Gly Glu Ala Leu Leu Gly Ser Glu Gln Phe Ala Glu Thr 
785                 790                 795                 800 


Pro Lys Glu Asn His Ser Asn Tyr Arg Thr Leu Leu Glu Lys Glu Lys 
                805                 810                 815     


Glu Trp Ala Leu Ala Val Ser Ser Ser Gln Leu Asn Thr Ile Val Thr 
            820                 825                 830         


Val Asn His His His Pro His His Pro Ala Val Gly Gly Val Ser Gly 
        835                 840                 845             


Val Val Gly Gly Thr Gly Gly Asp Leu Ala Gly Phe Arg His His Glu 
    850                 855                 860                 


Lys Asn Gly Gly Val Val Leu Phe Pro Pro Gly Gly Gly Cys Gly Ser 
865                 870                 875                 880 


Gly Ser Met Leu Leu Asp Arg Glu Arg Pro Gln Pro Ala Pro Cys Thr 
                885                 890                 895     


Val Gly Phe Val Asp Cys Leu Tyr Gly Thr Val Pro Lys Leu Lys Glu 
            900                 905                 910         


Leu His Val His Pro Pro Gly Met Gln Tyr Pro Asp Leu Gln Gln Asp 
        915                 920                 925             


Ala Arg Leu Lys Glu Thr Leu Leu Phe Ser Ala Gly Lys Gly Phe Thr 
    930                 935                 940                 


Asp His Gln Thr Gln Lys Ser Asp Tyr Leu Glu Leu Arg Ala Lys Leu 
945                 950                 955                 960 


Gln Thr Lys Pro Asp Tyr Leu Glu Val Leu Glu Lys Thr Thr Tyr Arg 
                965                 970                 975     


Phe 
    


<210>  4016
<211>  823
<212>  PRT
<213>  Homo sapiens

<400>  4016

Met Ala Leu Pro Arg Cys Thr Trp Pro Asn Tyr Val Trp Arg Ala Val 
1               5                   10                  15      


Met Ala Cys Leu Val His Arg Gly Leu Gly Ala Pro Leu Thr Leu Cys 
            20                  25                  30          


Met Leu Gly Cys Leu Leu Gln Ala Gly His Val Leu Ser Gln Lys Leu 
        35                  40                  45              


Asp Asp Val Asp Pro Leu Val Ala Thr Asn Phe Gly Lys Ile Arg Gly 
    50                  55                  60                  


Ile Lys Lys Glu Leu Asn Asn Glu Ile Leu Gly Pro Val Ile Gln Phe 
65                  70                  75                  80  


Leu Gly Val Pro Tyr Ala Ala Pro Pro Thr Gly Glu Arg Arg Phe Gln 
                85                  90                  95      


Pro Pro Glu Pro Pro Ser Pro Trp Ser Asp Ile Arg Asn Ala Thr Gln 
            100                 105                 110         


Phe Ala Pro Val Cys Pro Gln Asn Ile Ile Asp Gly Arg Leu Pro Glu 
        115                 120                 125             


Val Met Leu Pro Val Trp Phe Thr Asn Asn Leu Asp Val Val Ser Ser 
    130                 135                 140                 


Tyr Val Gln Asp Gln Ser Glu Asp Cys Leu Tyr Leu Asn Ile Tyr Val 
145                 150                 155                 160 


Pro Thr Glu Asp Asp Ile Arg Asp Ser Gly Gly Pro Lys Pro Val Met 
                165                 170                 175     


Val Tyr Ile His Gly Gly Ser Tyr Met Glu Gly Thr Gly Asn Leu Tyr 
            180                 185                 190         


Asp Gly Ser Val Leu Ala Ser Tyr Gly Asn Val Ile Val Ile Thr Val 
        195                 200                 205             


Asn Tyr Arg Leu Gly Val Leu Gly Phe Leu Ser Thr Gly Asp Gln Ala 
    210                 215                 220                 


Ala Lys Gly Asn Tyr Gly Leu Leu Asp Leu Ile Gln Ala Leu Arg Trp 
225                 230                 235                 240 


Thr Ser Glu Asn Ile Gly Phe Phe Gly Gly Asp Pro Leu Arg Ile Thr 
                245                 250                 255     


Val Phe Gly Ser Gly Ala Gly Gly Ser Cys Val Asn Leu Leu Thr Leu 
            260                 265                 270         


Ser His Tyr Ser Glu Gly Asn Arg Trp Ser Asn Ser Thr Lys Gly Leu 
        275                 280                 285             


Phe Gln Arg Ala Ile Ala Gln Ser Gly Thr Ala Leu Ser Ser Trp Ala 
    290                 295                 300                 


Val Ser Phe Gln Pro Ala Lys Tyr Ala Arg Met Leu Ala Thr Lys Val 
305                 310                 315                 320 


Gly Cys Asn Val Ser Asp Thr Val Glu Leu Val Glu Cys Leu Gln Lys 
                325                 330                 335     


Lys Pro Tyr Lys Glu Leu Val Asp Gln Asp Ile Gln Pro Ala Arg Tyr 
            340                 345                 350         


His Ile Ala Phe Gly Pro Val Ile Asp Gly Asp Val Ile Pro Asp Asp 
        355                 360                 365             


Pro Gln Ile Leu Met Glu Gln Gly Glu Phe Leu Asn Tyr Asp Ile Met 
    370                 375                 380                 


Leu Gly Val Asn Gln Gly Glu Gly Leu Lys Phe Val Glu Asn Ile Val 
385                 390                 395                 400 


Asp Ser Asp Asp Gly Ile Ser Ala Ser Asp Phe Asp Phe Ala Val Ser 
                405                 410                 415     


Asn Phe Val Asp Asn Leu Tyr Gly Tyr Pro Glu Gly Lys Asp Val Leu 
            420                 425                 430         


Arg Glu Thr Ile Lys Phe Met Tyr Thr Asp Trp Ala Asp Arg His Asn 
        435                 440                 445             


Pro Glu Thr Arg Arg Lys Thr Leu Leu Ala Leu Phe Thr Asp His Gln 
    450                 455                 460                 


Trp Val Ala Pro Ala Val Ala Thr Ala Asp Leu His Ser Asn Phe Gly 
465                 470                 475                 480 


Ser Pro Thr Tyr Phe Tyr Ala Phe Tyr His His Cys Gln Thr Asp Gln 
                485                 490                 495     


Val Pro Ala Trp Ala Asp Ala Ala His Gly Asp Glu Val Pro Tyr Val 
            500                 505                 510         


Leu Gly Ile Pro Met Ile Gly Pro Thr Glu Leu Phe Pro Cys Asn Phe 
        515                 520                 525             


Ser Lys Asn Asp Val Met Leu Ser Ala Val Val Met Thr Tyr Trp Thr 
    530                 535                 540                 


Asn Phe Ala Lys Thr Gly Asp Pro Asn Gln Pro Val Pro Gln Asp Thr 
545                 550                 555                 560 


Lys Phe Ile His Thr Lys Pro Asn Arg Phe Glu Glu Val Ala Trp Thr 
                565                 570                 575     


Arg Tyr Ser Gln Lys Asp Gln Leu Tyr Leu His Ile Gly Leu Lys Pro 
            580                 585                 590         


Arg Val Lys Glu His Tyr Arg Ala Asn Lys Val Asn Leu Trp Leu Glu 
        595                 600                 605             


Leu Val Pro His Leu His Asn Leu Asn Asp Ile Ser Gln Tyr Thr Ser 
    610                 615                 620                 


Thr Thr Thr Lys Val Pro Ser Thr Asp Ile Thr Phe Arg Pro Thr Arg 
625                 630                 635                 640 


Lys Asn Ser Val Pro Val Thr Ser Ala Phe Pro Thr Ala Lys Gln Asp 
                645                 650                 655     


Asp Pro Lys Gln Gln Pro Ser Pro Phe Ser Val Asp Gln Arg Asp Tyr 
            660                 665                 670         


Ser Thr Glu Leu Ser Val Thr Ile Ala Val Gly Ala Ser Leu Leu Phe 
        675                 680                 685             


Leu Asn Ile Leu Ala Phe Ala Ala Leu Tyr Tyr Lys Lys Asp Lys Arg 
    690                 695                 700                 


Arg His Asp Val His Arg Arg Cys Ser Pro Gln Arg Thr Thr Thr Asn 
705                 710                 715                 720 


Asp Leu Thr His Ala Gln Glu Glu Glu Ile Met Ser Leu Gln Met Lys 
                725                 730                 735     


His Thr Asp Leu Asp His Glu Cys Glu Ser Ile His Pro His Glu Val 
            740                 745                 750         


Val Leu Arg Thr Ala Cys Pro Pro Asp Tyr Thr Leu Ala Met Arg Arg 
        755                 760                 765             


Ser Pro Asp Asp Val Pro Leu Met Thr Pro Asn Thr Ile Thr Met Ile 
    770                 775                 780                 


Pro Asn Thr Ile Pro Gly Ile Gln Pro Leu His Thr Phe Asn Thr Phe 
785                 790                 795                 800 


Thr Gly Gly Gln Asn Asn Thr Leu Pro His Pro His Pro His Pro His 
                805                 810                 815     


Ser His Ser Thr Thr Arg Val 
            820             


<210>  4017
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  4017

Met Lys Leu Leu Val Ile Leu Leu Phe Ser Gly Leu Ile Thr Gly Phe 
1               5                   10                  15      


Arg Ser Asp Ser Ser Ser Ser Leu Pro Pro Lys Leu Leu Leu Val Ser 
            20                  25                  30          


Phe Asp Gly Phe Arg Ala Asp Tyr Leu Lys Asn Tyr Glu Phe Pro His 
        35                  40                  45              


Leu Gln Asn Phe Ile Lys Glu Gly Val Leu Val Glu His Val Lys Asn 
    50                  55                  60                  


Val Phe Ile Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly 
65                  70                  75                  80  


Leu Tyr Glu Glu Ser His Gly Ile Val Ala Asn Ser Met Tyr Asp Ala 
                85                  90                  95      


Val Thr Lys Lys His Phe Ser Asp Ser Asn Asp Lys Asp Pro Phe Trp 
            100                 105                 110         


Trp Asn Glu Ala Val Pro Ile Trp Val Thr Asn Gln Leu Gln Glu Asn 
        115                 120                 125             


Arg Ser Ser Ala Ala Ala Met Trp Pro Gly Thr Asp Val Pro Ile His 
    130                 135                 140                 


Asp Thr Ile Ser Ser Tyr Phe Met Asn Tyr Asn Ser Ser Val Ser Phe 
145                 150                 155                 160 


Glu Glu Arg Leu Asn Asn Ile Thr Met Trp Leu Asn Asn Ser Asn Pro 
                165                 170                 175     


Pro Val Thr Phe Ala Thr Leu Tyr Trp Glu Glu Pro Asp Ala Ser Gly 
            180                 185                 190         


His Lys Tyr Gly Pro Glu Asp Lys Glu Asn Met Ser Arg Val Leu Lys 
        195                 200                 205             


Lys Ile Asp Asp Leu Ile Gly Asp Leu Val Gln Arg Leu Lys Met Leu 
    210                 215                 220                 


Gly Leu Trp Glu Asn Leu Asn Val Ile Ile Thr Ser Asp His Gly Met 
225                 230                 235                 240 


Thr Gln Cys Ser Gln Asp Arg Leu Ile Asn Leu Asp Ser Cys Ile Asp 
                245                 250                 255     


His Ser Tyr Tyr Thr Leu Ile Asp Leu Ser Pro Val Ala Ala Ile Leu 
            260                 265                 270         


Pro Lys Ile Asn Arg Thr Glu Val Tyr Asn Lys Leu Lys Asn Cys Ser 
        275                 280                 285             


Pro His Met Asn Val Tyr Leu Lys Glu Asp Ile Pro Asn Arg Phe Tyr 
    290                 295                 300                 


Tyr Gln His Asn Asp Arg Ile Gln Pro Ile Ile Leu Val Ala Asp Glu 
305                 310                 315                 320 


Gly Trp Thr Ile Val Leu Asn Glu Ser Ser Gln Lys Leu Gly Asp His 
                325                 330                 335     


Gly Tyr Asp Asn Ser Leu Pro Ser Met His Pro Phe Leu Ala Ala His 
            340                 345                 350         


Gly Pro Ala Phe His Lys Gly Tyr Lys His Ser Thr Ile Asn Ile Val 
        355                 360                 365             


Asp Ile Tyr Pro Met Met Cys His Ile Leu Gly Leu Lys Pro His Pro 
    370                 375                 380                 


Asn Asn Gly Thr Phe Gly His Thr Lys Cys Leu Leu Val Asp Gln Trp 
385                 390                 395                 400 


Cys Ile Asn Leu Pro Glu Ala Ile Ala Ile Val Ile Gly Ser Leu Leu 
                405                 410                 415     


Val Leu Thr Met Leu Thr Cys Leu Ile Ile Ile Met Gln Asn Arg Leu 
            420                 425                 430         


Ser Val Pro Arg Pro Phe Ser Arg Leu Gln Leu Gln Glu Asp Asp Asp 
        435                 440                 445             


Asp Pro Leu Ile Gly 
    450             


<210>  4018
<211>  971
<212>  PRT
<213>  Homo sapiens

<400>  4018

Met Leu Arg Arg Pro Ala Pro Ala Leu Ala Pro Ala Ala Arg Leu Leu 
1               5                   10                  15      


Leu Ala Gly Leu Leu Cys Gly Gly Gly Val Trp Ala Ala Arg Val Asn 
            20                  25                  30          


Lys His Lys Pro Trp Leu Glu Pro Thr Tyr His Gly Ile Val Thr Glu 
        35                  40                  45              


Asn Asp Asn Thr Val Leu Leu Asp Pro Pro Leu Ile Ala Leu Asp Lys 
    50                  55                  60                  


Asp Ala Pro Leu Arg Phe Ala Gly Glu Ile Cys Gly Phe Lys Ile His 
65                  70                  75                  80  


Gly Gln Asn Val Pro Phe Asp Ala Val Val Val Asp Lys Ser Thr Gly 
                85                  90                  95      


Glu Gly Val Ile Arg Ser Lys Glu Lys Leu Asp Cys Glu Leu Gln Lys 
            100                 105                 110         


Asp Tyr Ser Phe Thr Ile Gln Ala Tyr Asp Cys Gly Lys Gly Pro Asp 
        115                 120                 125             


Gly Thr Asn Val Lys Lys Ser His Lys Ala Thr Val His Ile Gln Val 
    130                 135                 140                 


Asn Asp Val Asn Glu Tyr Ala Pro Val Phe Lys Glu Lys Ser Tyr Lys 
145                 150                 155                 160 


Ala Thr Val Ile Glu Gly Lys Gln Tyr Asp Ser Ile Leu Arg Val Glu 
                165                 170                 175     


Ala Val Asp Ala Asp Cys Ser Pro Gln Phe Ser Gln Ile Cys Ser Tyr 
            180                 185                 190         


Glu Ile Ile Thr Pro Asp Val Pro Phe Thr Val Asp Lys Asp Gly Tyr 
        195                 200                 205             


Ile Lys Asn Thr Glu Lys Leu Asn Tyr Gly Lys Glu His Gln Tyr Lys 
    210                 215                 220                 


Leu Thr Val Thr Ala Tyr Asp Cys Gly Lys Lys Arg Ala Thr Glu Asp 
225                 230                 235                 240 


Val Leu Val Lys Ile Ser Ile Lys Pro Thr Cys Thr Pro Gly Trp Gln 
                245                 250                 255     


Gly Trp Asn Asn Arg Ile Glu Tyr Glu Pro Gly Thr Gly Ala Leu Ala 
            260                 265                 270         


Val Phe Pro Asn Ile His Leu Glu Thr Cys Asp Glu Pro Val Ala Ser 
        275                 280                 285             


Val Gln Ala Thr Val Glu Leu Glu Thr Ser His Ile Gly Lys Gly Cys 
    290                 295                 300                 


Asp Arg Asp Thr Tyr Ser Glu Lys Ser Leu His Arg Leu Cys Gly Ala 
305                 310                 315                 320 


Ala Ala Gly Thr Ala Glu Leu Leu Pro Ser Pro Ser Gly Ser Leu Asn 
                325                 330                 335     


Trp Thr Met Gly Leu Pro Thr Asp Asn Gly His Asp Ser Asp Gln Val 
            340                 345                 350         


Phe Glu Phe Asn Gly Thr Gln Ala Val Arg Ile Pro Asp Gly Val Val 
        355                 360                 365             


Ser Val Ser Pro Lys Glu Pro Phe Thr Ile Ser Val Trp Met Arg His 
    370                 375                 380                 


Gly Pro Phe Gly Arg Lys Lys Glu Thr Ile Leu Cys Ser Ser Asp Lys 
385                 390                 395                 400 


Thr Asp Met Asn Arg His His Tyr Ser Leu Tyr Val His Gly Cys Arg 
                405                 410                 415     


Leu Ile Phe Leu Phe Arg Gln Asp Pro Ser Glu Glu Lys Lys Tyr Arg 
            420                 425                 430         


Pro Ala Glu Phe His Trp Lys Leu Asn Gln Val Cys Asp Glu Glu Trp 
        435                 440                 445             


His His Tyr Val Leu Asn Val Glu Phe Pro Ser Val Thr Leu Tyr Val 
    450                 455                 460                 


Asp Gly Thr Ser His Glu Pro Phe Ser Val Thr Glu Asp Tyr Pro Leu 
465                 470                 475                 480 


His Pro Ser Lys Ile Glu Thr Gln Leu Val Val Gly Ala Cys Trp Gln 
                485                 490                 495     


Glu Phe Ser Gly Val Glu Asn Asp Asn Glu Thr Glu Pro Val Thr Val 
            500                 505                 510         


Ala Ser Ala Gly Gly Asp Leu His Met Thr Gln Phe Phe Arg Gly Asn 
        515                 520                 525             


Leu Ala Gly Leu Thr Leu Arg Ser Gly Lys Leu Ala Asp Lys Lys Val 
    530                 535                 540                 


Ile Asp Cys Leu Tyr Thr Cys Lys Glu Gly Leu Asp Leu Gln Val Leu 
545                 550                 555                 560 


Glu Asp Ser Gly Arg Gly Val Gln Ile Gln Ala His Pro Ser Gln Leu 
                565                 570                 575     


Val Leu Thr Leu Glu Gly Glu Asp Leu Gly Glu Leu Asp Lys Ala Met 
            580                 585                 590         


Gln His Ile Ser Tyr Leu Asn Ser Arg Gln Phe Pro Thr Pro Gly Ile 
        595                 600                 605             


Arg Arg Leu Lys Ile Thr Ser Thr Ile Lys Cys Phe Asn Glu Ala Thr 
    610                 615                 620                 


Cys Ile Ser Val Pro Pro Val Asp Gly Tyr Val Met Val Leu Gln Pro 
625                 630                 635                 640 


Glu Glu Pro Lys Ile Ser Leu Ser Gly Val His His Phe Ala Arg Ala 
                645                 650                 655     


Ala Ser Glu Phe Glu Ser Ser Glu Gly Val Phe Leu Phe Pro Glu Leu 
            660                 665                 670         


Arg Ile Ile Ser Thr Ile Thr Arg Glu Val Glu Pro Glu Gly Asp Gly 
        675                 680                 685             


Ala Glu Asp Pro Thr Val Gln Glu Ser Leu Val Ser Glu Glu Ile Val 
    690                 695                 700                 


His Asp Leu Asp Thr Cys Glu Val Thr Val Glu Gly Glu Glu Leu Asn 
705                 710                 715                 720 


His Glu Gln Glu Ser Leu Glu Val Asp Met Ala Arg Leu Gln Gln Lys 
                725                 730                 735     


Gly Ile Glu Val Ser Ser Ser Glu Leu Gly Met Thr Phe Thr Gly Val 
            740                 745                 750         


Asp Thr Met Ala Ser Tyr Glu Glu Val Leu His Leu Leu Arg Tyr Arg 
        755                 760                 765             


Asn Trp His Ala Arg Ser Leu Leu Asp Arg Lys Phe Lys Leu Ile Cys 
    770                 775                 780                 


Ser Glu Leu Asn Gly Arg Tyr Ile Ser Asn Glu Phe Lys Val Glu Val 
785                 790                 795                 800 


Asn Val Ile His Thr Ala Asn Pro Met Glu His Ala Asn His Met Ala 
                805                 810                 815     


Ala Gln Pro Gln Phe Val His Pro Glu His Arg Ser Phe Val Asp Leu 
            820                 825                 830         


Ser Gly His Asn Leu Ala Asn Pro His Pro Phe Ala Val Val Pro Ser 
        835                 840                 845             


Thr Ala Thr Val Val Ile Val Val Cys Val Ser Phe Leu Val Phe Met 
    850                 855                 860                 


Ile Ile Leu Gly Val Phe Arg Ile Arg Ala Ala His Arg Arg Thr Met 
865                 870                 875                 880 


Arg Asp Gln Asp Thr Gly Lys Glu Asn Glu Met Asp Trp Asp Asp Ser 
                885                 890                 895     


Ala Leu Thr Ile Thr Val Asn Pro Met Glu Thr Tyr Glu Asp Gln His 
            900                 905                 910         


Ser Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Ser Glu Asp 
        915                 920                 925             


Gly Glu Glu Glu Asp Asp Ile Thr Ser Ala Glu Ser Glu Ser Ser Glu 
    930                 935                 940                 


Glu Glu Glu Gly Glu Gln Gly Asp Pro Gln Asn Ala Thr Arg Gln Gln 
945                 950                 955                 960 


Gln Leu Glu Trp Asp Asp Ser Thr Leu Ser Tyr 
                965                 970     


<210>  4019
<211>  616
<212>  PRT
<213>  Homo sapiens

<400>  4019

Met Asn Ser Pro Gly Gly Arg Gly Lys Lys Lys Gly Ser Gly Gly Ala 
1               5                   10                  15      


Ser Asn Pro Val Pro Pro Arg Pro Pro Pro Pro Cys Leu Ala Pro Ala 
            20                  25                  30          


Pro Pro Ala Ala Gly Pro Ala Pro Pro Pro Glu Ser Pro His Lys Arg 
        35                  40                  45              


Asn Leu Tyr Tyr Phe Ser Tyr Pro Leu Phe Val Gly Phe Ala Leu Leu 
    50                  55                  60                  


Arg Leu Val Ala Phe His Leu Gly Leu Leu Phe Val Trp Leu Cys Gln 
65                  70                  75                  80  


Arg Phe Ser Arg Ala Leu Met Ala Ala Lys Arg Ser Ser Gly Ala Ala 
                85                  90                  95      


Pro Ala Pro Ala Ser Ala Ser Ala Pro Ala Pro Val Pro Gly Gly Glu 
            100                 105                 110         


Ala Glu Arg Val Arg Val Phe His Lys Gln Ala Phe Glu Tyr Ile Ser 
        115                 120                 125             


Ile Ala Leu Arg Ile Asp Glu Asp Glu Lys Ala Gly Gln Lys Glu Gln 
    130                 135                 140                 


Ala Val Glu Trp Tyr Lys Lys Gly Ile Glu Glu Leu Glu Lys Gly Ile 
145                 150                 155                 160 


Ala Val Ile Val Thr Gly Gln Gly Glu Gln Cys Glu Arg Ala Arg Arg 
                165                 170                 175     


Leu Gln Ala Lys Met Met Thr Asn Leu Val Met Ala Lys Asp Arg Leu 
            180                 185                 190         


Gln Leu Leu Glu Lys Met Gln Pro Val Leu Pro Phe Ser Lys Ser Gln 
        195                 200                 205             


Thr Asp Val Tyr Asn Asp Ser Thr Asn Leu Ala Cys Arg Asn Gly His 
    210                 215                 220                 


Leu Gln Ser Glu Ser Gly Ala Val Pro Lys Arg Lys Asp Pro Leu Thr 
225                 230                 235                 240 


His Thr Ser Asn Ser Leu Pro Arg Ser Lys Thr Val Met Lys Thr Gly 
                245                 250                 255     


Ser Ala Gly Leu Ser Gly His His Arg Ala Pro Ser Tyr Ser Gly Leu 
            260                 265                 270         


Ser Met Val Ser Gly Val Lys Gln Gly Ser Gly Pro Ala Pro Thr Thr 
        275                 280                 285             


His Lys Gly Thr Pro Lys Thr Asn Arg Thr Asn Lys Pro Ser Thr Pro 
    290                 295                 300                 


Thr Thr Ala Thr Arg Lys Lys Lys Asp Leu Lys Asn Phe Arg Asn Val 
305                 310                 315                 320 


Asp Ser Asn Leu Ala Asn Leu Ile Met Asn Glu Ile Val Asp Asn Gly 
                325                 330                 335     


Thr Ala Val Lys Phe Asp Asp Ile Ala Gly Gln Asp Leu Ala Lys Gln 
            340                 345                 350         


Ala Leu Gln Glu Ile Val Ile Leu Pro Ser Leu Arg Pro Glu Leu Phe 
        355                 360                 365             


Thr Gly Leu Arg Ala Pro Ala Arg Gly Leu Leu Leu Phe Gly Pro Pro 
    370                 375                 380                 


Gly Asn Gly Lys Thr Met Leu Ala Lys Ala Val Ala Ala Glu Ser Asn 
385                 390                 395                 400 


Ala Thr Phe Phe Asn Ile Ser Ala Ala Ser Leu Thr Ser Lys Tyr Val 
                405                 410                 415     


Gly Glu Gly Glu Lys Leu Val Arg Ala Leu Phe Ala Val Ala Arg Glu 
            420                 425                 430         


Leu Gln Pro Ser Ile Ile Phe Ile Asp Glu Val Asp Ser Leu Leu Cys 
        435                 440                 445             


Glu Arg Arg Glu Gly Glu His Asp Ala Ser Arg Arg Leu Lys Thr Glu 
    450                 455                 460                 


Phe Leu Ile Glu Phe Asp Gly Val Gln Ser Ala Gly Asp Asp Arg Val 
465                 470                 475                 480 


Leu Val Met Gly Ala Thr Asn Arg Pro Gln Glu Leu Asp Glu Ala Val 
                485                 490                 495     


Leu Arg Arg Phe Ile Lys Arg Val Tyr Val Ser Leu Pro Asn Glu Glu 
            500                 505                 510         


Thr Arg Leu Leu Leu Leu Lys Asn Leu Leu Cys Lys Gln Gly Ser Pro 
        515                 520                 525             


Leu Thr Gln Lys Glu Leu Ala Gln Leu Ala Arg Met Thr Asp Gly Tyr 
    530                 535                 540                 


Ser Gly Ser Asp Leu Thr Ala Leu Ala Lys Asp Ala Ala Leu Gly Pro 
545                 550                 555                 560 


Ile Arg Glu Leu Lys Pro Glu Gln Val Lys Asn Met Ser Ala Ser Glu 
                565                 570                 575     


Met Arg Asn Ile Arg Leu Ser Asp Phe Thr Glu Ser Leu Lys Lys Ile 
            580                 585                 590         


Lys Arg Ser Val Ser Pro Gln Thr Leu Glu Ala Tyr Ile Arg Trp Asn 
        595                 600                 605             


Lys Asp Phe Gly Asp Thr Thr Val 
    610                 615     


<210>  4020
<211>  1556
<212>  PRT
<213>  Homo sapiens

<400>  4020

Met Ala Asp Arg Ser Leu Glu Gly Met Ala Leu Pro Leu Glu Val Arg 
1               5                   10                  15      


Ala Arg Leu Ala Glu Leu Glu Leu Glu Leu Ser Glu Gly Asp Ile Thr 
            20                  25                  30          


Gln Lys Gly Tyr Glu Lys Lys Arg Ser Lys Leu Ile Gly Ala Tyr Leu 
        35                  40                  45              


Pro Gln Pro Pro Arg Val Asp Gln Ala Leu Pro Gln Glu Arg Arg Ala 
    50                  55                  60                  


Pro Val Thr Pro Ser Ser Ala Ser Arg Tyr His Arg Arg Arg Ser Ser 
65                  70                  75                  80  


Gly Ser Arg Asp Glu Arg Tyr Arg Ser Asp Val His Thr Glu Ala Val 
                85                  90                  95      


Gln Ala Ala Leu Ala Lys His Lys Glu Arg Lys Met Ala Val Pro Met 
            100                 105                 110         


Pro Ser Lys Arg Arg Ser Leu Val Val Gln Thr Ser Met Asp Ala Tyr 
        115                 120                 125             


Thr Pro Pro Asp Thr Ser Ser Gly Ser Glu Asp Glu Gly Ser Val Gln 
    130                 135                 140                 


Gly Asp Ser Gln Gly Thr Pro Thr Ser Ser Gln Gly Ser Ile Asn Met 
145                 150                 155                 160 


Glu His Trp Ile Ser Gln Ala Ile His Gly Ser Thr Thr Ser Thr Thr 
                165                 170                 175     


Ser Ser Ser Ser Thr Gln Ser Gly Gly Ser Gly Ala Ala His Arg Leu 
            180                 185                 190         


Ala Asp Val Met Ala Gln Thr His Ile Glu Asn His Ser Ala Pro Pro 
        195                 200                 205             


Asp Val Thr Thr Tyr Thr Ser Glu His Ser Ile Gln Val Glu Arg Pro 
    210                 215                 220                 


Gln Gly Ser Thr Gly Ser Arg Thr Ala Pro Lys Tyr Gly Asn Ala Glu 
225                 230                 235                 240 


Leu Met Glu Thr Gly Asp Gly Val Pro Val Ser Ser Arg Val Ser Ala 
                245                 250                 255     


Lys Ile Gln Gln Leu Val Asn Thr Leu Lys Arg Pro Lys Arg Pro Pro 
            260                 265                 270         


Leu Arg Glu Phe Phe Val Asp Asp Phe Glu Glu Leu Leu Glu Val Gln 
        275                 280                 285             


Gln Pro Asp Pro Asn Gln Pro Lys Pro Glu Gly Ala Gln Met Leu Ala 
    290                 295                 300                 


Met Arg Gly Glu Gln Leu Gly Val Val Thr Asn Trp Pro Pro Ser Leu 
305                 310                 315                 320 


Glu Ala Ala Leu Gln Arg Trp Gly Thr Ile Ser Pro Lys Ala Pro Cys 
                325                 330                 335     


Leu Thr Thr Met Asp Thr Asn Gly Lys Pro Leu Tyr Ile Leu Thr Tyr 
            340                 345                 350         


Gly Lys Leu Trp Thr Arg Ser Met Lys Val Ala Tyr Ser Ile Leu His 
        355                 360                 365             


Lys Leu Gly Thr Lys Gln Glu Pro Met Val Arg Pro Gly Asp Arg Val 
    370                 375                 380                 


Ala Leu Val Phe Pro Asn Asn Asp Pro Ala Ala Phe Met Ala Ala Phe 
385                 390                 395                 400 


Tyr Gly Cys Leu Leu Ala Glu Val Val Pro Val Pro Ile Glu Val Pro 
                405                 410                 415     


Leu Thr Arg Lys Asp Ala Gly Ser Gln Gln Ile Gly Phe Leu Leu Gly 
            420                 425                 430         


Ser Cys Gly Val Thr Val Ala Leu Thr Ser Asp Ala Cys His Lys Gly 
        435                 440                 445             


Leu Pro Lys Ser Pro Thr Gly Glu Ile Pro Gln Phe Lys Gly Trp Pro 
    450                 455                 460                 


Lys Leu Leu Trp Phe Val Thr Glu Ser Lys His Leu Ser Lys Pro Pro 
465                 470                 475                 480 


Arg Asp Trp Phe Pro His Ile Lys Asp Ala Asn Asn Asp Thr Ala Tyr 
                485                 490                 495     


Ile Glu Tyr Lys Thr Cys Lys Asp Gly Ser Val Leu Gly Val Thr Val 
            500                 505                 510         


Thr Arg Thr Ala Leu Leu Thr His Cys Gln Ala Leu Thr Gln Ala Cys 
        515                 520                 525             


Gly Tyr Thr Glu Ala Glu Thr Ile Val Asn Val Leu Asp Phe Lys Lys 
    530                 535                 540                 


Asp Val Gly Leu Trp His Gly Ile Leu Thr Ser Val Met Asn Met Met 
545                 550                 555                 560 


His Val Ile Ser Ile Pro Tyr Ser Leu Met Lys Val Asn Pro Leu Ser 
                565                 570                 575     


Trp Ile Gln Lys Val Cys Gln Tyr Lys Ala Lys Val Ala Cys Val Lys 
            580                 585                 590         


Ser Arg Asp Met His Trp Ala Leu Val Ala His Arg Asp Gln Arg Asp 
        595                 600                 605             


Ile Asn Leu Ser Ser Leu Arg Met Leu Ile Val Ala Asp Gly Ala Asn 
    610                 615                 620                 


Pro Trp Ser Ile Ser Ser Cys Asp Ala Phe Leu Asn Val Phe Gln Ser 
625                 630                 635                 640 


Lys Gly Leu Arg Gln Glu Val Ile Cys Pro Cys Ala Ser Ser Pro Glu 
                645                 650                 655     


Ala Leu Thr Val Ala Ile Arg Arg Pro Thr Asp Asp Ser Asn Gln Pro 
            660                 665                 670         


Pro Gly Arg Gly Val Leu Ser Met His Gly Leu Thr Tyr Gly Val Ile 
        675                 680                 685             


Arg Val Asp Ser Glu Glu Lys Leu Ser Val Leu Thr Val Gln Asp Val 
    690                 695                 700                 


Gly Leu Val Met Pro Gly Ala Ile Met Cys Ser Val Lys Pro Asp Gly 
705                 710                 715                 720 


Val Pro Gln Leu Cys Arg Thr Asp Glu Ile Gly Glu Leu Cys Val Cys 
                725                 730                 735     


Ala Val Ala Thr Gly Thr Ser Tyr Tyr Gly Leu Ser Gly Met Thr Lys 
            740                 745                 750         


Asn Thr Phe Glu Val Phe Pro Met Thr Ser Ser Gly Ala Pro Ile Ser 
        755                 760                 765             


Glu Tyr Pro Phe Ile Arg Thr Gly Leu Leu Gly Phe Val Gly Pro Gly 
    770                 775                 780                 


Gly Leu Val Phe Val Val Gly Lys Met Asp Gly Leu Met Val Val Ser 
785                 790                 795                 800 


Gly Arg Arg His Asn Ala Asp Asp Ile Val Ala Thr Ala Leu Ala Val 
                805                 810                 815     


Glu Pro Met Lys Phe Val Tyr Arg Gly Arg Ile Ala Val Phe Ser Val 
            820                 825                 830         


Thr Val Leu His Asp Glu Arg Ile Val Ile Val Ala Glu Gln Arg Pro 
        835                 840                 845             


Asp Ser Thr Glu Glu Asp Ser Phe Gln Trp Met Ser Arg Val Leu Gln 
    850                 855                 860                 


Ala Ile Asp Ser Ile His Gln Val Gly Val Tyr Cys Leu Ala Leu Val 
865                 870                 875                 880 


Pro Ala Asn Thr Leu Pro Lys Thr Pro Leu Gly Gly Ile His Leu Ser 
                885                 890                 895     


Glu Thr Lys Gln Leu Phe Leu Glu Gly Ser Leu His Pro Cys Asn Val 
            900                 905                 910         


Leu Met Cys Pro His Thr Cys Val Thr Asn Leu Pro Lys Pro Arg Gln 
        915                 920                 925             


Lys Gln Pro Glu Ile Gly Pro Ala Ser Val Met Val Gly Asn Leu Val 
    930                 935                 940                 


Ser Gly Lys Arg Ile Ala Gln Ala Ser Gly Arg Asp Leu Gly Gln Ile 
945                 950                 955                 960 


Glu Asp Asn Asp Gln Ala Arg Lys Phe Leu Phe Leu Ser Glu Val Leu 
                965                 970                 975     


Gln Trp Arg Ala Gln Thr Thr Pro Asp His Ile Leu Tyr Thr Leu Leu 
            980                 985                 990         


Asn Cys Arg Gly Ala Ile Ala Asn  Ser Leu Thr Cys Val  Gln Leu His 
        995                 1000                 1005             


Lys Arg  Ala Glu Lys Ile Ala  Val Met Leu Met Glu  Arg Gly His 
    1010                 1015                 1020             


Leu Gln  Asp Gly Asp His Val  Ala Leu Val Tyr Pro  Pro Gly Ile 
    1025                 1030                 1035             


Asp Leu  Ile Ala Ala Phe Tyr  Gly Cys Leu Tyr Ala  Gly Cys Val 
    1040                 1045                 1050             


Pro Ile  Thr Val Arg Pro Pro  His Pro Gln Asn Ile  Ala Thr Thr 
    1055                 1060                 1065             


Leu Pro  Thr Val Lys Met Ile  Val Glu Val Ser Arg  Ser Ala Cys 
    1070                 1075                 1080             


Leu Met  Thr Thr Gln Leu Ile  Cys Lys Leu Leu Arg  Ser Arg Glu 
    1085                 1090                 1095             


Ala Ala  Ala Ala Val Asp Val  Arg Thr Trp Pro Leu  Ile Leu Asp 
    1100                 1105                 1110             


Thr Asp  Asp Leu Pro Lys Lys  Arg Pro Ala Gln Ile  Cys Lys Pro 
    1115                 1120                 1125             


Cys Asn  Pro Asp Thr Leu Ala  Tyr Leu Asp Phe Ser  Val Ser Thr 
    1130                 1135                 1140             


Thr Gly  Met Leu Ala Gly Val  Lys Met Ser His Ala  Ala Thr Ser 
    1145                 1150                 1155             


Ala Phe  Cys Arg Ser Ile Lys  Leu Gln Cys Glu Leu  Tyr Pro Ser 
    1160                 1165                 1170             


Arg Glu  Val Ala Ile Cys Leu  Asp Pro Tyr Cys Gly  Leu Gly Phe 
    1175                 1180                 1185             


Val Leu  Trp Cys Leu Cys Ser  Val Tyr Ser Gly His  Gln Ser Ile 
    1190                 1195                 1200             


Leu Ile  Pro Pro Ser Glu Leu  Glu Thr Asn Pro Ala  Leu Trp Leu 
    1205                 1210                 1215             


Leu Ala  Val Ser Gln Tyr Lys  Val Arg Asp Thr Phe  Cys Ser Tyr 
    1220                 1225                 1230             


Ser Val  Met Glu Leu Cys Thr  Lys Gly Leu Gly Ser  Gln Thr Glu 
    1235                 1240                 1245             


Ser Leu  Lys Ala Arg Gly Leu  Asp Leu Ser Arg Val  Arg Thr Cys 
    1250                 1255                 1260             


Val Val  Val Ala Glu Glu Arg  Pro Arg Ile Ala Leu  Thr Gln Ser 
    1265                 1270                 1275             


Phe Ser  Lys Leu Phe Lys Asp  Leu Gly Leu His Pro  Arg Ala Val 
    1280                 1285                 1290             


Ser Thr  Ser Phe Gly Cys Arg  Val Asn Leu Ala Ile  Cys Leu Gln 
    1295                 1300                 1305             


Gly Thr  Ser Gly Pro Asp Pro  Thr Thr Val Tyr Val  Asp Met Arg 
    1310                 1315                 1320             


Ala Leu  Arg His Asp Arg Val  Arg Leu Val Glu Arg  Gly Ser Pro 
    1325                 1330                 1335             


His Ser  Leu Pro Leu Met Glu  Ser Gly Lys Ile Leu  Pro Gly Val 
    1340                 1345                 1350             


Arg Ile  Ile Ile Ala Asn Pro  Glu Thr Lys Gly Pro  Leu Gly Asp 
    1355                 1360                 1365             


Ser His  Leu Gly Glu Ile Trp  Val His Ser Ala His  Asn Ala Ser 
    1370                 1375                 1380             


Gly Tyr  Phe Thr Ile Tyr Gly  Asp Glu Ser Leu Gln  Ser Asp His 
    1385                 1390                 1395             


Phe Asn  Ser Arg Leu Ser Phe  Gly Asp Thr Gln Thr  Ile Trp Ala 
    1400                 1405                 1410             


Arg Thr  Gly Tyr Leu Gly Phe  Leu Arg Arg Thr Glu  Leu Thr Asp 
    1415                 1420                 1425             


Ala Asn  Gly Glu Arg His Asp  Ala Leu Tyr Val Val  Gly Ala Leu 
    1430                 1435                 1440             


Asp Glu  Ala Met Glu Leu Arg  Gly Met Arg Tyr His  Pro Ile Asp 
    1445                 1450                 1455             


Ile Glu  Thr Ser Val Ile Arg  Ala His Lys Ser Val  Thr Glu Cys 
    1460                 1465                 1470             


Ala Val  Phe Thr Trp Thr Asn  Leu Leu Val Val Val  Val Glu Leu 
    1475                 1480                 1485             


Asp Gly  Ser Glu Gln Glu Ala  Leu Asp Leu Val Pro  Leu Val Thr 
    1490                 1495                 1500             


Asn Val  Val Leu Glu Glu His  Tyr Leu Ile Val Gly  Val Val Val 
    1505                 1510                 1515             


Val Val  Asp Ile Gly Val Ile  Pro Ile Asn Ser Arg  Gly Glu Lys 
    1520                 1525                 1530             


Gln Arg  Met His Leu Arg Asp  Gly Phe Leu Ala Asp  Gln Leu Asp 
    1535                 1540                 1545             


Pro Ile  Tyr Val Ala Tyr Asn  Met 
    1550                 1555     


<210>  4021
<211>  1222
<212>  PRT
<213>  Homo sapiens

<400>  4021

Met Glu Ala Ala Arg Thr Glu Arg Pro Ala Gly Arg Pro Gly Ala Pro 
1               5                   10                  15      


Leu Val Arg Thr Gly Leu Leu Leu Leu Ser Thr Trp Val Leu Ala Gly 
            20                  25                  30          


Ala Glu Ile Thr Trp Asp Ala Thr Gly Gly Pro Gly Arg Pro Ala Ala 
        35                  40                  45              


Pro Ala Ser Arg Pro Pro Ala Leu Ser Pro Leu Ser Pro Arg Ala Val 
    50                  55                  60                  


Ala Ser Gln Trp Pro Glu Glu Leu Ala Ser Ala Arg Arg Ala Ala Val 
65                  70                  75                  80  


Leu Gly Arg Arg Ala Gly Pro Glu Leu Leu Pro Gln Gln Gly Gly Gly 
                85                  90                  95      


Arg Gly Gly Glu Met Gln Val Glu Ala Gly Gly Thr Ser Pro Ala Gly 
            100                 105                 110         


Glu Arg Arg Gly Arg Gly Ile Pro Ala Pro Ala Lys Leu Gly Gly Ala 
        115                 120                 125             


Arg Arg Ser Arg Arg Ala Gln Pro Pro Ile Thr Gln Glu Arg Gly Asp 
    130                 135                 140                 


Ala Trp Ala Thr Ala Pro Ala Asp Gly Ser Arg Gly Ser Arg Pro Leu 
145                 150                 155                 160 


Ala Lys Gly Ser Arg Glu Glu Val Lys Ala Pro Arg Ala Gly Gly Ser 
                165                 170                 175     


Ala Ala Glu Asp Leu Arg Leu Pro Ser Thr Ser Phe Ala Leu Thr Gly 
            180                 185                 190         


Asp Ser Ala His Asn Gln Ala Met Val His Trp Ser Gly His Asn Ser 
        195                 200                 205             


Ser Val Ile Leu Ile Leu Thr Lys Leu Tyr Asp Phe Asn Leu Gly Ser 
    210                 215                 220                 


Val Thr Glu Ser Ser Leu Trp Arg Ser Thr Asp Tyr Gly Thr Thr Tyr 
225                 230                 235                 240 


Glu Lys Leu Asn Asp Lys Val Gly Leu Lys Thr Val Leu Ser Tyr Leu 
                245                 250                 255     


Tyr Val Asn Pro Thr Asn Lys Arg Lys Ile Met Leu Leu Ser Asp Pro 
            260                 265                 270         


Glu Met Glu Ser Ser Ile Leu Ile Ser Ser Asp Glu Gly Ala Thr Tyr 
        275                 280                 285             


Gln Lys Tyr Arg Leu Thr Phe Tyr Ile Gln Ser Leu Leu Phe His Pro 
    290                 295                 300                 


Lys Gln Glu Asp Trp Val Leu Ala Tyr Ser Leu Asp Gln Lys Leu Tyr 
305                 310                 315                 320 


Ser Ser Met Asp Phe Gly Arg Arg Trp Gln Leu Met His Glu Arg Ile 
                325                 330                 335     


Thr Pro Asn Arg Phe Tyr Trp Ser Val Ala Gly Leu Asp Lys Glu Ala 
            340                 345                 350         


Asp Leu Val His Met Glu Val Arg Thr Thr Asp Gly Tyr Ala His Tyr 
        355                 360                 365             


Leu Thr Cys Arg Ile Gln Glu Cys Ala Glu Thr Thr Arg Ser Gly Pro 
    370                 375                 380                 


Phe Ala Arg Ser Ile Asp Ile Ser Ser Leu Val Val Gln Asp Glu Tyr 
385                 390                 395                 400 


Ile Phe Ile Gln Val Thr Thr Ser Gly Arg Ala Ser Tyr Tyr Val Ser 
                405                 410                 415     


Tyr Arg Arg Glu Ala Phe Ala Gln Ile Lys Leu Pro Lys Tyr Ser Leu 
            420                 425                 430         


Pro Lys Asp Met His Ile Ile Ser Thr Asp Glu Asn Gln Val Phe Ala 
        435                 440                 445             


Ala Val Gln Glu Trp Asn Gln Asn Asp Thr Tyr Asn Leu Tyr Ile Ser 
    450                 455                 460                 


Asp Thr Arg Gly Ile Tyr Phe Thr Leu Ala Met Glu Asn Ile Lys Ser 
465                 470                 475                 480 


Ser Arg Gly Leu Met Gly Asn Ile Ile Ile Glu Leu Tyr Glu Val Ala 
                485                 490                 495     


Gly Ile Lys Gly Ile Phe Leu Ala Asn Lys Lys Val Asp Asp Gln Val 
            500                 505                 510         


Lys Thr Tyr Ile Thr Tyr Asn Lys Gly Arg Asp Trp Arg Leu Leu Gln 
        515                 520                 525             


Ala Pro Asp Val Asp Leu Arg Gly Ser Pro Val His Cys Leu Leu Pro 
    530                 535                 540                 


Phe Cys Ser Leu His Leu His Leu Gln Leu Ser Glu Asn Pro Tyr Ser 
545                 550                 555                 560 


Ser Gly Arg Ile Ser Ser Lys Glu Thr Ala Pro Gly Leu Val Val Ala 
                565                 570                 575     


Thr Gly Asn Ile Gly Pro Glu Leu Ser Tyr Thr Asp Ile Gly Val Phe 
            580                 585                 590         


Ile Ser Ser Asp Gly Gly Asn Thr Trp Arg Gln Ile Phe Asp Glu Glu 
        595                 600                 605             


Tyr Asn Val Trp Phe Leu Asp Trp Gly Gly Ala Leu Val Ala Met Lys 
    610                 615                 620                 


His Thr Pro Leu Pro Val Arg His Leu Trp Val Ser Phe Asp Glu Gly 
625                 630                 635                 640 


His Ser Trp Asp Lys Tyr Gly Phe Thr Ser Val Pro Leu Phe Val Asp 
                645                 650                 655     


Gly Ala Leu Val Glu Ala Gly Met Glu Thr His Ile Met Thr Val Phe 
            660                 665                 670         


Gly His Phe Ser Leu Arg Ser Glu Trp Gln Leu Val Lys Val Asp Tyr 
        675                 680                 685             


Lys Ser Ile Phe Ser Arg His Cys Thr Lys Glu Asp Tyr Gln Thr Trp 
    690                 695                 700                 


His Leu Leu Asn Gln Gly Glu Pro Cys Val Met Gly Glu Arg Lys Ile 
705                 710                 715                 720 


Phe Lys Lys Arg Lys Pro Gly Ala Gln Cys Ala Leu Gly Arg Asp His 
                725                 730                 735     


Ser Gly Ser Val Val Ser Glu Pro Cys Val Cys Ala Asn Trp Asp Phe 
            740                 745                 750         


Glu Cys Asp Tyr Gly Tyr Glu Arg His Gly Glu Ser Gln Cys Val Pro 
        755                 760                 765             


Ala Phe Trp Tyr Asn Pro Ala Ser Pro Ser Lys Asp Cys Ser Leu Gly 
    770                 775                 780                 


Gln Ser Tyr Leu Asn Ser Thr Gly Tyr Arg Arg Ile Val Ser Asn Asn 
785                 790                 795                 800 


Cys Thr Asp Gly Leu Arg Glu Lys Tyr Thr Ala Lys Ala Gln Met Cys 
                805                 810                 815     


Pro Gly Lys Ala Pro Arg Gly Leu His Val Val Thr Thr Asp Gly Arg 
            820                 825                 830         


Leu Val Ala Glu Gln Gly His Asn Ala Thr Phe Ile Ile Leu Met Glu 
        835                 840                 845             


Glu Gly Asp Leu Gln Arg Thr Asn Ile Gln Leu Asp Phe Gly Asp Gly 
    850                 855                 860                 


Ile Ala Val Ser Tyr Ala Asn Phe Ser Pro Ile Glu Asp Gly Ile Lys 
865                 870                 875                 880 


His Val Tyr Lys Ser Ala Gly Ile Phe Gln Val Thr Ala Tyr Ala Glu 
                885                 890                 895     


Asn Asn Leu Gly Ser Asp Thr Ala Val Leu Phe Leu His Val Val Cys 
            900                 905                 910         


Pro Val Glu His Val His Leu Arg Val Pro Phe Val Ala Ile Arg Asn 
        915                 920                 925             


Lys Glu Val Asn Ile Ser Ala Val Val Trp Pro Ser Gln Leu Gly Thr 
    930                 935                 940                 


Leu Thr Tyr Phe Trp Trp Phe Gly Asn Ser Thr Lys Pro Leu Ile Thr 
945                 950                 955                 960 


Leu Asp Ser Ser Ile Ser Phe Thr Phe Leu Ala Glu Gly Thr Asp Thr 
                965                 970                 975     


Ile Thr Val Gln Val Ala Ala Gly Asn Ala Leu Ile Gln Asp Thr Lys 
            980                 985                 990         


Glu Ile Ala Val His Glu Tyr Phe  Gln Ser Gln Leu Leu  Ser Phe Ser 
        995                 1000                 1005             


Pro Asn  Leu Asp Tyr His Asn  Pro Asp Ile Pro Glu  Trp Arg Lys 
    1010                 1015                 1020             


Asp Ile  Gly Asn Val Ile Lys  Arg Ala Leu Val Lys  Val Thr Ser 
    1025                 1030                 1035             


Val Pro  Glu Asp Gln Ile Leu  Ile Ala Val Phe Pro  Gly Leu Pro 
    1040                 1045                 1050             


Thr Ser  Ala Glu Leu Phe Ile  Leu Pro Pro Lys Asn  Leu Thr Glu 
    1055                 1060                 1065             


Arg Arg  Lys Gly Asn Glu Gly  Asp Leu Glu Gln Ile  Val Glu Thr 
    1070                 1075                 1080             


Leu Phe  Asn Ala Leu Asn Gln  Asn Leu Val Gln Phe  Glu Leu Lys 
    1085                 1090                 1095             


Pro Gly  Val Gln Val Ile Val  Tyr Val Thr Gln Leu  Thr Leu Ala 
    1100                 1105                 1110             


Pro Leu  Val Asp Ser Ser Ala  Gly His Ser Ser Ser  Ala Met Leu 
    1115                 1120                 1125             


Met Leu  Leu Ser Val Val Phe  Val Gly Leu Ala Val  Phe Leu Ile 
    1130                 1135                 1140             


Tyr Lys  Phe Lys Arg Lys Ile  Pro Trp Ile Asn Ile  Tyr Ala Gln 
    1145                 1150                 1155             


Val Gln  His Asp Lys Glu Gln  Glu Met Ile Gly Ser  Val Ser Gln 
    1160                 1165                 1170             


Ser Glu  Asn Ala Pro Lys Ile  Thr Leu Ser Asp Phe  Thr Glu Pro 
    1175                 1180                 1185             


Glu Glu  Leu Leu Asp Lys Glu  Leu Asp Thr Arg Val  Ile Gly Gly 
    1190                 1195                 1200             


Ile Ala  Thr Ile Ala Asn Ser  Glu Ser Thr Lys Glu  Ile Pro Asn 
    1205                 1210                 1215             


Cys Thr  Ser Val 
    1220         


<210>  4022
<211>  727
<212>  PRT
<213>  Homo sapiens

<400>  4022

Met Glu Asp Ser Tyr Lys Asp Arg Thr Ser Leu Met Lys Gly Ala Lys 
1               5                   10                  15      


Asp Ile Ala Arg Glu Val Lys Lys Gln Thr Val Lys Lys Val Asn Gln 
            20                  25                  30          


Ala Val Asp Arg Ala Gln Asp Glu Tyr Thr Gln Arg Ser Tyr Ser Arg 
        35                  40                  45              


Phe Gln Asp Glu Glu Asp Asp Asp Asp Tyr Tyr Pro Ala Gly Glu Thr 
    50                  55                  60                  


Tyr Asn Gly Glu Ala Asn Asp Asp Glu Gly Ser Ser Glu Ala Thr Glu 
65                  70                  75                  80  


Gly His Asp Glu Asp Asp Glu Ile Tyr Glu Gly Glu Tyr Gln Gly Ile 
                85                  90                  95      


Pro Ser Met Asn Gln Ala Lys Asp Ser Ile Val Ser Val Gly Gln Pro 
            100                 105                 110         


Lys Gly Asp Glu Tyr Lys Asp Arg Arg Glu Leu Glu Ser Glu Arg Arg 
        115                 120                 125             


Ala Asp Glu Glu Glu Leu Ala Gln Gln Tyr Glu Leu Ile Ile Gln Glu 
    130                 135                 140                 


Cys Gly His Gly Arg Phe Gln Trp Ala Leu Phe Phe Val Leu Gly Met 
145                 150                 155                 160 


Ala Leu Met Ala Asp Gly Val Glu Val Phe Val Val Gly Phe Val Leu 
                165                 170                 175     


Pro Ser Ala Glu Thr Asp Leu Cys Ile Pro Asn Ser Gly Ser Gly Trp 
            180                 185                 190         


Leu Gly Ser Ile Val Tyr Leu Gly Met Met Val Gly Ala Phe Phe Trp 
        195                 200                 205             


Gly Gly Leu Ala Asp Lys Val Gly Arg Lys Gln Ser Leu Leu Ile Cys 
    210                 215                 220                 


Met Ser Val Asn Gly Phe Phe Ala Phe Leu Ser Ser Phe Val Gln Gly 
225                 230                 235                 240 


Tyr Gly Phe Phe Leu Phe Cys Arg Leu Leu Ser Gly Phe Gly Ile Gly 
                245                 250                 255     


Gly Ala Ile Pro Thr Val Phe Ser Tyr Phe Ala Glu Val Leu Ala Arg 
            260                 265                 270         


Glu Lys Arg Gly Glu His Leu Ser Trp Leu Cys Met Phe Trp Met Ile 
        275                 280                 285             


Gly Gly Ile Tyr Ala Ser Ala Met Ala Trp Ala Ile Ile Pro His Tyr 
    290                 295                 300                 


Gly Trp Ser Phe Ser Met Gly Ser Ala Tyr Gln Phe His Ser Trp Arg 
305                 310                 315                 320 


Val Phe Val Ile Val Cys Ala Leu Pro Cys Val Ser Ser Val Val Ala 
                325                 330                 335     


Leu Thr Phe Met Pro Glu Ser Pro Arg Phe Leu Leu Glu Val Gly Lys 
            340                 345                 350         


His Asp Glu Ala Trp Met Ile Leu Lys Leu Ile His Asp Thr Asn Met 
        355                 360                 365             


Arg Ala Arg Gly Gln Pro Glu Lys Val Phe Thr Val Asn Lys Ile Lys 
    370                 375                 380                 


Thr Pro Lys Gln Ile Asp Glu Leu Ile Glu Ile Glu Ser Asp Thr Gly 
385                 390                 395                 400 


Thr Trp Tyr Arg Arg Cys Phe Val Arg Ile Arg Thr Glu Leu Tyr Gly 
                405                 410                 415     


Ile Trp Leu Thr Phe Met Arg Cys Phe Asn Tyr Pro Val Arg Asp Asn 
            420                 425                 430         


Thr Ile Lys Leu Thr Ile Val Trp Phe Thr Leu Ser Phe Gly Tyr Tyr 
        435                 440                 445             


Gly Leu Ser Val Trp Phe Pro Asp Val Ile Lys Pro Leu Gln Ser Asp 
    450                 455                 460                 


Glu Tyr Ala Leu Leu Thr Arg Asn Val Glu Arg Asp Lys Tyr Ala Asn 
465                 470                 475                 480 


Phe Thr Ile Asn Phe Thr Met Glu Asn Gln Ile His Thr Gly Met Glu 
                485                 490                 495     


Tyr Asp Asn Gly Arg Phe Ile Gly Val Lys Phe Lys Ser Val Thr Phe 
            500                 505                 510         


Lys Asp Ser Val Phe Lys Ser Cys Thr Phe Glu Asp Val Thr Ser Val 
        515                 520                 525             


Asn Thr Tyr Phe Lys Asn Cys Thr Phe Ile Asp Thr Val Phe Asp Asn 
    530                 535                 540                 


Thr Asp Phe Glu Pro Tyr Lys Phe Ile Asp Ser Glu Phe Lys Asn Cys 
545                 550                 555                 560 


Ser Phe Phe His Asn Lys Thr Gly Cys Gln Ile Thr Phe Asp Asp Asp 
                565                 570                 575     


Tyr Ser Ala Tyr Trp Ile Tyr Phe Val Asn Phe Leu Gly Thr Leu Ala 
            580                 585                 590         


Val Leu Pro Gly Asn Ile Val Ser Ala Leu Leu Met Asp Arg Ile Gly 
        595                 600                 605             


Arg Leu Thr Met Leu Gly Gly Ser Met Val Leu Ser Gly Ile Ser Cys 
    610                 615                 620                 


Phe Phe Leu Trp Phe Gly Thr Ser Glu Ser Met Met Ile Gly Met Leu 
625                 630                 635                 640 


Cys Leu Tyr Asn Gly Leu Thr Ile Ser Ala Trp Asn Ser Leu Asp Val 
                645                 650                 655     


Val Thr Val Glu Leu Tyr Pro Thr Asp Arg Arg Ala Thr Gly Phe Gly 
            660                 665                 670         


Phe Leu Asn Ala Leu Cys Lys Ala Ala Ala Val Leu Gly Asn Leu Ile 
        675                 680                 685             


Phe Gly Ser Leu Val Ser Ile Thr Lys Ser Ile Pro Ile Leu Leu Ala 
    690                 695                 700                 


Ser Thr Val Leu Val Cys Gly Gly Leu Val Gly Leu Cys Leu Pro Asp 
705                 710                 715                 720 


Thr Arg Thr Gln Val Leu Met 
                725         


<210>  4023
<211>  2341
<212>  PRT
<213>  Homo sapiens

<400>  4023

Met Gly Ser Gln Thr Leu Gln Ile Leu Arg Gln Gly Val Trp Ala Ala 
1               5                   10                  15      


Leu Ser Gly Gly Trp Tyr Tyr Asp Pro His Gln Ala Thr Phe Val Asn 
            20                  25                  30          


Ala Leu His Leu Tyr Leu Trp Leu Phe Leu Leu Gly Leu Pro Phe Thr 
        35                  40                  45              


Leu Tyr Met Ala Leu Pro Ser Thr Met Ile Ile Val Ala Val Tyr Cys 
    50                  55                  60                  


Pro Val Ile Ala Ala Val Phe Ile Val Leu Lys Met Val Asn Tyr Arg 
65                  70                  75                  80  


Leu His Arg Ala Leu Asp Ala Gly Glu Val Val Asp Arg Thr Ala Asn 
                85                  90                  95      


Glu Phe Thr Asp Gln Arg Thr Lys Ala Glu Gln Gly Asn Cys Ser Thr 
            100                 105                 110         


Arg Arg Lys Asp Ser Asn Gly Pro Ser Asp Pro Gly Gly Gly Ile Glu 
        115                 120                 125             


Met Ser Glu Phe Ile Arg Glu Ala Thr Pro Pro Val Gly Cys Ser Ser 
    130                 135                 140                 


Arg Asn Ser Tyr Ala Gly Leu Asp Pro Ser Asn Gln Ile Gly Ser Gly 
145                 150                 155                 160 


Ser Ser Arg Leu Gly Thr Ala Ala Thr Ile Lys Gly Asp Thr Asp Thr 
                165                 170                 175     


Ala Lys Thr Ser Asp Asp Ile Ser Leu Ser Leu Gly Gln Ser Ser Ser 
            180                 185                 190         


Leu Cys Lys Glu Gly Ser Glu Glu Gln Asp Leu Ala Ala Asp Arg Lys 
        195                 200                 205             


Leu Phe Arg Leu Val Ser Asn Asp Ser Phe Ile Ser Ile Gln Pro Ser 
    210                 215                 220                 


Leu Ser Ser Cys Gly Gln Asp Leu Pro Arg Asp Phe Ser Asp Lys Val 
225                 230                 235                 240 


Asn Leu Pro Ser His Asn His His His His Val Asp Gln Ser Leu Ser 
                245                 250                 255     


Ser Ala Cys Asp Thr Glu Val Ala Ser Leu Val Pro Leu His Ser His 
            260                 265                 270         


Ser Tyr Arg Lys Asp His Arg Pro Arg Gly Val Pro Arg Thr Ser Ser 
        275                 280                 285             


Ser Ala Val Ala Phe Pro Asp Thr Ser Leu Asn Asp Phe Pro Leu Tyr 
    290                 295                 300                 


Gln Gln Arg Arg Gly Leu Asp Pro Val Ser Glu Leu Glu Ser Ser Lys 
305                 310                 315                 320 


Pro Leu Ser Gly Ser Lys Glu Ser Leu Val Glu Asn Ser Gly Leu Ser 
                325                 330                 335     


Gly Glu Phe Gln Leu Ala Gly Asp Leu Lys Ile Asn Thr Ser Gln Pro 
            340                 345                 350         


Pro Thr Lys Ser Gly Lys Ser Lys Pro Leu Lys Ala Glu Lys Ser Met 
        355                 360                 365             


Asp Ser Leu Arg Ser Leu Ser Thr Arg Ser Ser Gly Ser Thr Glu Ser 
    370                 375                 380                 


Tyr Cys Ser Gly Thr Asp Arg Asp Thr Asn Ser Thr Val Ser Ser Tyr 
385                 390                 395                 400 


Lys Ser Glu Gln Thr Ser Ser Thr His Ile Glu Ser Ile Leu Ser Glu 
                405                 410                 415     


His Glu Glu Ser Pro Lys Ala Gly Thr Lys Ser Gly Arg Lys Lys Glu 
            420                 425                 430         


Cys Cys Ala Gly Pro Glu Glu Lys Asn Ser Cys Ala Ser Asp Lys Arg 
        435                 440                 445             


Thr Ser Ser Glu Lys Ile Ala Met Glu Ala Ser Thr Asn Ser Gly Val 
    450                 455                 460                 


His Glu Ala Lys Asp Pro Thr Pro Ser Asp Glu Met His Asn Gln Arg 
465                 470                 475                 480 


Gly Leu Ser Thr Ser Ala Ser Glu Glu Ala Asn Lys Asn Pro His Ala 
                485                 490                 495     


Asn Glu Phe Thr Ser Gln Gly Asp Arg Pro Pro Gly Asn Thr Ala Glu 
            500                 505                 510         


Asn Lys Glu Glu Lys Ser Asp Lys Ser Ala Val Ser Val Asp Ser Lys 
        515                 520                 525             


Val Arg Lys Asp Val Gly Gly Lys Gln Lys Glu Gly Asp Val Arg Pro 
    530                 535                 540                 


Lys Ser Ser Ser Val Ile His Arg Thr Ala Ser Ala His Lys Ser Gly 
545                 550                 555                 560 


Arg Arg Arg Thr Gly Lys Lys Arg Ala Ser Ser Phe Asp Ser Ser Arg 
                565                 570                 575     


His Arg Asp Tyr Val Cys Phe Arg Gly Val Ser Gly Thr Lys Pro His 
            580                 585                 590         


Ser Ala Ile Phe Cys His Asp Glu Asp Ser Ser Asp Gln Ser Asp Leu 
        595                 600                 605             


Ser Arg Ala Ser Ser Val Gln Ser Ala His Gln Phe Ser Ser Asp Ser 
    610                 615                 620                 


Ser Ser Ser Thr Thr Ser His Ser Cys Gln Ser Pro Glu Gly Arg Tyr 
625                 630                 635                 640 


Ser Ala Leu Lys Thr Lys His Thr His Lys Glu Arg Gly Thr Asp Ser 
                645                 650                 655     


Glu His Thr His Lys Ala His Leu Val Pro Glu Gly Thr Ser Lys Lys 
            660                 665                 670         


Arg Ala Thr Arg Arg Thr Ser Ser Thr Asn Ser Ala Lys Thr Arg Ala 
        675                 680                 685             


Arg Val Leu Ser Leu Asp Ser Gly Thr Val Ala Cys Leu Asn Asp Ser 
    690                 695                 700                 


Asn Arg Leu Met Ala Pro Glu Ser Ile Lys Pro Leu Thr Thr Ser Lys 
705                 710                 715                 720 


Ser Asp Leu Glu Ala Lys Glu Gly Glu Val Leu Asp Glu Leu Ser Leu 
                725                 730                 735     


Leu Gly Arg Ala Ser Gln Leu Glu Thr Val Thr Arg Ser Arg Asn Ser 
            740                 745                 750         


Leu Pro Asn Gln Val Ala Phe Pro Glu Gly Glu Glu Gln Asp Ala Val 
        755                 760                 765             


Ser Gly Ala Ala Gln Ala Ser Glu Glu Ala Val Ser Phe Arg Arg Glu 
    770                 775                 780                 


Arg Ser Thr Phe Arg Arg Gln Ala Val Arg Arg Arg His Asn Ala Gly 
785                 790                 795                 800 


Ser Asn Pro Thr Pro Pro Thr Leu Leu Ile Gly Ser Pro Leu Ser Leu 
                805                 810                 815     


Gln Asp Gly Gln Gln Gly Gln Gln Ser Thr Ala Gln Val Lys Val Gln 
            820                 825                 830         


Ser Arg Pro Pro Ser Gln Ala Ala Val Leu Ser Ala Ser Ala Ser Leu 
        835                 840                 845             


Leu Val Arg Asn Gly Ser Val His Leu Glu Ala Ser His Asp Asn Ala 
    850                 855                 860                 


Ser Ala Val Gly Gly Ser Ser Leu His Asp Glu Leu Gly Lys Phe Ser 
865                 870                 875                 880 


Ser Thr Leu Tyr Glu Thr Gly Gly Cys Asp Met Ser Leu Val Asn Phe 
                885                 890                 895     


Glu Pro Ala Ala Arg Arg Ala Ser Asn Ile Cys Asp Thr Asp Ser His 
            900                 905                 910         


Val Ser Ser Ser Thr Ser Val Arg Phe Tyr Pro His Asp Val Leu Ser 
        915                 920                 925             


Leu Pro Gln Ile Arg Leu Asn Arg Leu Leu Thr Ile Asp Thr Asp Leu 
    930                 935                 940                 


Leu Glu Gln Gln Asp Ile Asp Leu Ser Pro Asp Leu Ala Ala Thr Tyr 
945                 950                 955                 960 


Gly Pro Thr Glu Glu Ala Ala Gln Lys Val Lys His Tyr Tyr Arg Phe 
                965                 970                 975     


Trp Ile Leu Pro Gln Leu Trp Ile Gly Ile Asn Phe Asp Arg Leu Thr 
            980                 985                 990         


Leu Leu Ala Leu Phe Asp Arg Asn  Arg Glu Ile Leu Glu  Asn Val Leu 
        995                 1000                 1005             


Ala Val  Ile Leu Ala Ile Leu  Val Ala Phe Leu Gly  Ser Ile Leu 
    1010                 1015                 1020             


Leu Ile  Gln Gly Phe Phe Arg  Asp Ile Trp Val Phe  Gln Phe Cys 
    1025                 1030                 1035             


Leu Val  Ile Ala Ser Cys Gln  Tyr Ser Leu Leu Lys  Ser Val Gln 
    1040                 1045                 1050             


Pro Asp  Ser Ser Ser Pro Arg  His Gly His Asn Arg  Ile Ile Ala 
    1055                 1060                 1065             


Tyr Ser  Arg Pro Val Tyr Phe  Cys Ile Cys Cys Gly  Leu Ile Trp 
    1070                 1075                 1080             


Leu Leu  Asp Tyr Gly Ser Arg  Asn Leu Thr Ala Thr  Lys Phe Lys 
    1085                 1090                 1095             


Leu Tyr  Gly Ile Thr Phe Thr  Asn Pro Leu Val Phe  Ile Ser Ala 
    1100                 1105                 1110             


Arg Asp  Leu Val Ile Val Phe  Thr Leu Cys Phe Pro  Ile Val Phe 
    1115                 1120                 1125             


Phe Ile  Gly Leu Leu Pro Gln  Val Asn Thr Phe Val  Met Tyr Leu 
    1130                 1135                 1140             


Cys Glu  Gln Leu Asp Ile His  Ile Phe Gly Gly Asn  Ala Thr Thr 
    1145                 1150                 1155             


Ser Leu  Leu Ala Ala Leu Tyr  Ser Phe Ile Cys Ser  Ile Val Ala 
    1160                 1165                 1170             


Val Ala  Leu Leu Tyr Gly Leu  Cys Tyr Gly Ala Leu  Lys Asp Ser 
    1175                 1180                 1185             


Trp Asp  Gly Gln His Ile Pro  Val Leu Phe Ser Ile  Phe Cys Gly 
    1190                 1195                 1200             


Leu Leu  Val Ala Val Ser Tyr  His Leu Ser Arg Gln  Ser Ser Asp 
    1205                 1210                 1215             


Pro Ser  Val Leu Phe Ser Leu  Val Gln Ser Lys Ile  Phe Pro Lys 
    1220                 1225                 1230             


Thr Glu  Glu Lys Asn Pro Glu  Asp Pro Leu Ser Glu  Val Lys Asp 
    1235                 1240                 1245             


Pro Leu  Pro Glu Lys Leu Arg  Asn Ser Val Ser Glu  Arg Leu Gln 
    1250                 1255                 1260             


Ser Asp  Leu Val Val Cys Ile  Val Ile Gly Val Leu  Tyr Phe Ala 
    1265                 1270                 1275             


Ile His  Val Ser Thr Val Phe  Thr Val Leu Gln Pro  Ala Leu Lys 
    1280                 1285                 1290             


Tyr Val  Leu Tyr Thr Leu Val  Gly Phe Val Gly Phe  Val Thr His 
    1295                 1300                 1305             


Tyr Val  Leu Pro Gln Val Arg  Lys Gln Leu Pro Trp  His Cys Phe 
    1310                 1315                 1320             


Ser His  Pro Leu Leu Lys Thr  Leu Glu Tyr Asn Gln  Tyr Glu Val 
    1325                 1330                 1335             


Arg Asn  Ala Ala Thr Met Met  Trp Phe Glu Lys Leu  His Val Trp 
    1340                 1345                 1350             


Leu Leu  Phe Val Glu Lys Asn  Ile Ile Tyr Pro Leu  Ile Val Leu 
    1355                 1360                 1365             


Asn Glu  Leu Ser Ser Ser Ala  Glu Thr Ile Ala Ser  Pro Lys Lys 
    1370                 1375                 1380             


Leu Asn  Thr Glu Leu Gly Ala  Leu Met Ile Thr Val  Ala Gly Leu 
    1385                 1390                 1395             


Lys Leu  Leu Arg Ser Ser Phe  Ser Ser Pro Thr Tyr  Gln Tyr Val 
    1400                 1405                 1410             


Thr Val  Ile Phe Thr Val Leu  Phe Phe Lys Phe Asp  Tyr Glu Ala 
    1415                 1420                 1425             


Phe Ser  Glu Thr Met Leu Leu  Asp Leu Phe Phe Met  Ser Ile Leu 
    1430                 1435                 1440             


Phe Asn  Lys Leu Trp Glu Leu  Leu Tyr Lys Leu Gln  Phe Val Tyr 
    1445                 1450                 1455             


Thr Tyr  Ile Ala Pro Trp Gln  Ile Thr Trp Gly Ser  Ala Phe His 
    1460                 1465                 1470             


Ala Phe  Ala Gln Pro Phe Ala  Val Pro His Ser Ala  Met Leu Phe 
    1475                 1480                 1485             


Ile Gln  Ala Ala Val Ser Ala  Phe Phe Ser Thr Pro  Leu Asn Pro 
    1490                 1495                 1500             


Phe Leu  Gly Ser Ala Ile Phe  Ile Thr Ser Tyr Val  Arg Pro Val 
    1505                 1510                 1515             


Lys Phe  Trp Glu Arg Asp Tyr  Asn Thr Lys Arg Val  Asp His Ser 
    1520                 1525                 1530             


Asn Thr  Arg Leu Ala Ser Gln  Leu Asp Arg Asn Pro  Gly Ser Asp 
    1535                 1540                 1545             


Asp Asn  Asn Leu Asn Ser Ile  Phe Tyr Glu His Leu  Thr Arg Ser 
    1550                 1555                 1560             


Leu Gln  His Ser Leu Cys Gly  Asp Leu Leu Leu Gly  Arg Trp Gly 
    1565                 1570                 1575             


Asn Tyr  Ser Thr Gly Asp Cys  Phe Ile Leu Ala Ser  Asp Tyr Leu 
    1580                 1585                 1590             


Asn Ala  Leu Val His Leu Ile  Glu Ile Gly Asn Gly  Leu Val Thr 
    1595                 1600                 1605             


Phe Gln  Leu Arg Gly Leu Glu  Phe Arg Gly Thr Tyr  Cys Gln Gln 
    1610                 1615                 1620             


Arg Glu  Val Glu Ala Ile Thr  Glu Gly Val Glu Glu  Asp Glu Gly 
    1625                 1630                 1635             


Phe Cys  Cys Cys Glu Pro Gly  His Ile Pro His Met  Leu Ser Phe 
    1640                 1645                 1650             


Asn Ala  Ala Phe Ser Gln Arg  Trp Leu Ala Trp Glu  Val Ile Val 
    1655                 1660                 1665             


Thr Lys  Tyr Ile Leu Glu Gly  Tyr Ser Ile Thr Asp  Asn Ser Ala 
    1670                 1675                 1680             


Ala Ser  Met Leu Gln Val Phe  Asp Leu Arg Lys Val  Leu Thr Thr 
    1685                 1690                 1695             


Tyr Tyr  Val Lys Gly Ile Ile  Tyr Tyr Val Thr Thr  Ser Ser Lys 
    1700                 1705                 1710             


Leu Glu  Glu Trp Leu Ala Asn  Glu Thr Met Gln Glu  Gly Leu Arg 
    1715                 1720                 1725             


Leu Cys  Ala Asp Arg Asn Tyr  Val Asp Val Asp Pro  Thr Phe Asn 
    1730                 1735                 1740             


Pro Asn  Ile Asp Glu Asp Tyr  Asp His Arg Leu Ala  Gly Ile Ser 
    1745                 1750                 1755             


Arg Glu  Ser Phe Cys Val Ile  Tyr Leu Asn Trp Ile  Glu Tyr Cys 
    1760                 1765                 1770             


Ser Ser  Arg Arg Ala Lys Pro  Val Asp Val Asp Lys  Asp Ser Ser 
    1775                 1780                 1785             


Leu Val  Thr Leu Cys Tyr Gly  Leu Cys Val Leu Gly  Arg Arg Ala 
    1790                 1795                 1800             


Leu Gly  Thr Ala Ser His His  Met Ser Ser Asn Leu  Glu Ser Phe 
    1805                 1810                 1815             


Leu Tyr  Gly Leu His Ala Leu  Phe Lys Gly Asp Phe  Arg Ile Ser 
    1820                 1825                 1830             


Ser Ile  Arg Asp Glu Trp Ile  Phe Ala Asp Met Glu  Leu Leu Arg 
    1835                 1840                 1845             


Lys Val  Val Val Pro Gly Ile  Arg Met Ser Ile Lys  Leu His Gln 
    1850                 1855                 1860             


Asp His  Phe Thr Ser Pro Asp  Glu Tyr Asp Asp Pro  Thr Val Leu 
    1865                 1870                 1875             


Tyr Glu  Ala Ile Val Ser His  Glu Lys Asn Leu Val  Ile Ala His 
    1880                 1885                 1890             


Glu Gly  Asp Pro Ala Trp Arg  Ser Ala Val Leu Ala  Asn Ser Pro 
    1895                 1900                 1905             


Ser Leu  Leu Ala Leu Arg His  Val Met Asp Asp Gly  Thr Asn Glu 
    1910                 1915                 1920             


Tyr Lys  Ile Ile Met Leu Asn  Arg Arg Tyr Leu Ser  Phe Arg Val 
    1925                 1930                 1935             


Ile Lys  Val Asn Lys Glu Cys  Val Arg Gly Leu Trp  Ala Gly Gln 
    1940                 1945                 1950             


Gln Gln  Glu Leu Val Phe Leu  Arg Asn Arg Asn Pro  Glu Arg Gly 
    1955                 1960                 1965             


Ser Ile  Gln Asn Ala Lys Gln  Ala Leu Arg Asn Met  Ile Asn Ser 
    1970                 1975                 1980             


Ser Cys  Asp Gln Pro Ile Gly  Tyr Pro Ile Phe Val  Ser Pro Leu 
    1985                 1990                 1995             


Thr Thr  Ser Tyr Ser Asp Ser  His Glu Gln Leu Lys  Asp Ile Leu 
    2000                 2005                 2010             


Gly Gly  Pro Ile Ser Leu Gly  Asn Ile Arg Asn Phe  Ile Val Ser 
    2015                 2020                 2025             


Thr Trp  His Arg Leu Arg Lys  Gly Cys Gly Ala Gly  Cys Asn Ser 
    2030                 2035                 2040             


Gly Gly  Asn Ile Glu Asp Ser  Asp Thr Gly Gly Gly  Thr Ser Cys 
    2045                 2050                 2055             


Thr Gly  Asn Asn Ala Thr Thr  Ala Asn Asn Pro His  Ser Asn Val 
    2060                 2065                 2070             


Thr Gln  Gly Ser Ile Gly Asn  Pro Gly Gln Gly Ser  Gly Thr Gly 
    2075                 2080                 2085             


Leu His  Pro Pro Val Thr Ser  Tyr Pro Pro Thr Leu  Gly Thr Ser 
    2090                 2095                 2100             


His Ser  Ser His Ser Val Gln  Ser Gly Leu Val Arg  Gln Ser Pro 
    2105                 2110                 2115             


Ala Arg  Ala Ser Val Ala Ser  Gln Ser Ser Tyr Cys  Tyr Ser Ser 
    2120                 2125                 2130             


Arg His  Ser Ser Leu Arg Met  Ser Thr Thr Gly Phe  Val Pro Cys 
    2135                 2140                 2145             


Arg Arg  Ser Ser Thr Ser Gln  Ile Ser Leu Arg Asn  Leu Pro Ser 
    2150                 2155                 2160             


Ser Ile  Gln Ser Arg Leu Ser  Met Val Asn Gln Met  Glu Pro Ser 
    2165                 2170                 2175             


Gly Gln  Ser Gly Leu Ala Cys  Val Gln His Gly Leu  Pro Ser Ser 
    2180                 2185                 2190             


Ser Ser  Ser Ser Gln Ser Ile  Pro Ala Cys Lys His  His Thr Leu 
    2195                 2200                 2205             


Val Gly  Phe Leu Ala Thr Glu  Gly Gly Gln Ser Ser  Ala Thr Asp 
    2210                 2215                 2220             


Ala Gln  Pro Gly Asn Thr Leu  Ser Pro Ala Asn Asn  Ser His Ser 
    2225                 2230                 2235             


Arg Lys  Ala Glu Val Ile Tyr  Arg Val Gln Ile Val  Asp Pro Ser 
    2240                 2245                 2250             


Gln Ile  Leu Glu Gly Ile Asn  Leu Ser Lys Arg Lys  Glu Leu Gln 
    2255                 2260                 2265             


Trp Pro  Asp Glu Gly Ile Arg  Leu Lys Ala Gly Arg  Asn Ser Trp 
    2270                 2275                 2280             


Lys Asp  Trp Ser Pro Gln Glu  Gly Met Glu Gly His  Val Ile His 
    2285                 2290                 2295             


Arg Trp  Val Pro Cys Ser Arg  Asp Pro Gly Thr Arg  Ser His Ile 
    2300                 2305                 2310             


Asp Lys  Ala Val Leu Leu Val  Gln Ile Asp Asp Lys  Tyr Val Thr 
    2315                 2320                 2325             


Val Ile  Glu Thr Gly Val Leu  Glu Leu Gly Ala Glu  Val 
    2330                 2335                 2340     


<210>  4024
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  4024

Met Ser Ala Ala Gln Gly Trp Asp Arg Asn Arg Arg Arg Gly Gly Gly 
1               5                   10                  15      


Ala Ala Gly Ala Gly Gly Gly Gly Ser Gly Ala Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Ser Gly Gly Arg Gly Thr Gly Gln Leu Asn Arg Phe Val Gln Leu 
        35                  40                  45              


Ser Gly Arg Pro His Leu Pro Gly Lys Lys Lys Ile Arg Trp Asp Pro 
    50                  55                  60                  


Val Arg Arg Arg Phe Ile Gln Ser Cys Pro Ile Ile Arg Ile Pro Asn 
65                  70                  75                  80  


Arg Phe Leu Arg Gly His Arg Pro Pro Pro Ala Arg Ser Gly His Arg 
                85                  90                  95      


Cys Val Ala Asp Asn Thr Asn Leu Tyr Val Phe Gly Gly Tyr Asn Pro 
            100                 105                 110         


Asp Tyr Asp Glu Ser Gly Gly Pro Asp Asn Glu Asp Tyr Pro Leu Phe 
        115                 120                 125             


Arg Glu Leu Trp Arg Tyr His Phe Ala Thr Gly Val Trp His Gln Met 
    130                 135                 140                 


Gly Thr Asp Gly Tyr Met Pro Arg Glu Leu Ala Ser Met Ser Leu Val 
145                 150                 155                 160 


Leu His Gly Asn Asn Leu Leu Val Phe Gly Gly Thr Gly Ile Pro Phe 
                165                 170                 175     


Gly Glu Ser Asn Gly Asn Asp Val His Val Cys Asn Val Lys Tyr Lys 
            180                 185                 190         


Arg Trp Ala Leu Leu Ser Cys Arg Gly Lys Lys Pro Ser Arg Ile Tyr 
        195                 200                 205             


Gly Gln Ala Met Ala Ile Ile Asn Gly Ser Leu Tyr Val Phe Gly Gly 
    210                 215                 220                 


Thr Thr Gly Tyr Ile Tyr Ser Thr Asp Leu His Lys Leu Asp Leu Asn 
225                 230                 235                 240 


Thr Arg Glu Trp Thr Gln Leu Lys Pro Asn Asn Leu Ser Cys Asp Leu 
                245                 250                 255     


Pro Glu Glu Arg Tyr Arg His Glu Ile Ala His Asp Gly Gln Arg Ile 
            260                 265                 270         


Tyr Ile Leu Gly Gly Gly Thr Ser Trp Thr Ala Tyr Ser Leu Asn Lys 
        275                 280                 285             


Ile His Ala Tyr Asn Leu Glu Thr Asn Ala Trp Glu Glu Ile Ala Thr 
    290                 295                 300                 


Lys Pro His Glu Lys Ile Gly Phe Pro Ala Ala Arg Arg Cys His Ser 
305                 310                 315                 320 


Cys Val Gln Ile Lys Asn Asp Val Phe Ile Cys Gly Gly Tyr Asn Gly 
                325                 330                 335     


Glu Val Ile Leu Gly Asp Ile Trp Lys Leu Asn Leu Gln Thr Phe Gln 
            340                 345                 350         


Trp Val Lys Leu Pro Ala Thr Met Pro Glu Pro Val Tyr Phe His Cys 
        355                 360                 365             


Ala Ala Val Thr Pro Ala Gly Cys Met Tyr Ile His Gly Gly Val Val 
    370                 375                 380                 


Asn Ile His Glu Asn Lys Arg Thr Gly Ser Leu Phe Lys Ile Trp Leu 
385                 390                 395                 400 


Val Val Pro Ser Leu Leu Glu Leu Ala Trp Glu Lys Leu Leu Ala Ala 
                405                 410                 415     


Phe Pro Asn Leu Ala Asn Leu Ser Arg Thr Gln Leu Leu His Leu Gly 
            420                 425                 430         


Leu Thr Gln Gly Leu Ile Glu Arg Leu Lys 
        435                 440         


<210>  4025
<211>  653
<212>  PRT
<213>  Homo sapiens

<400>  4025

Met Glu Pro Ser Gly Ser Glu Gln Leu Phe Glu Asp Pro Asp Pro Gly 
1               5                   10                  15      


Gly Lys Ser Gln Asp Ala Glu Ala Arg Lys Gln Thr Glu Ser Glu Gln 
            20                  25                  30          


Lys Leu Ser Lys Met Thr His Asn Ala Leu Glu Asn Ile Asn Val Ile 
        35                  40                  45              


Gly Gln Gly Leu Lys His Leu Phe Gln His Gln Arg Arg Arg Ser Ser 
    50                  55                  60                  


Val Ser Pro His Asp Val Gln Gln Ile Gln Ala Asp Pro Glu Pro Glu 
65                  70                  75                  80  


Met Asp Leu Glu Ser Gln Asn Ala Cys Ala Glu Ile Asp Gly Val Pro 
                85                  90                  95      


Thr His Pro Thr Ala Leu Asn Arg Val Leu Gln Gln Ile Arg Val Pro 
            100                 105                 110         


Pro Lys Met Lys Arg Gly Thr Ser Leu His Ser Arg Arg Gly Lys Pro 
        115                 120                 125             


Glu Ala Pro Lys Gly Ser Pro Gln Ile Asn Arg Lys Ser Gly Gln Glu 
    130                 135                 140                 


Met Thr Ala Val Met Gln Ser Gly Arg Pro Arg Ser Ser Ser Thr Thr 
145                 150                 155                 160 


Asp Ala Pro Thr Ser Ser Ala Met Met Glu Ile Ala Cys Ala Ala Ala 
                165                 170                 175     


Ala Ala Ala Ala Ala Cys Leu Pro Gly Glu Glu Gly Thr Ala Glu Arg 
            180                 185                 190         


Ile Glu Arg Leu Glu Val Ser Ser Leu Ala Gln Thr Ser Ser Ala Val 
        195                 200                 205             


Ala Ser Ser Thr Asp Gly Ser Ile His Thr Asp Ser Val Asp Gly Thr 
    210                 215                 220                 


Pro Asp Pro Gln Arg Thr Lys Ala Ala Ile Ala His Leu Gln Gln Lys 
225                 230                 235                 240 


Ile Leu Lys Leu Thr Glu Gln Ile Lys Ile Ala Gln Thr Ala Arg Asp 
                245                 250                 255     


Asp Asn Val Ala Glu Tyr Leu Lys Leu Ala Asn Ser Ala Asp Lys Gln 
            260                 265                 270         


Gln Ala Ala Arg Ile Lys Gln Val Phe Glu Lys Lys Asn Gln Lys Ser 
        275                 280                 285             


Ala Gln Thr Ile Leu Gln Leu Gln Lys Lys Leu Glu His Tyr His Arg 
    290                 295                 300                 


Lys Leu Arg Glu Val Glu Gln Asn Gly Ile Pro Arg Gln Pro Lys Asp 
305                 310                 315                 320 


Val Phe Arg Asp Met His Gln Gly Leu Lys Asp Val Gly Ala Lys Val 
                325                 330                 335     


Thr Gly Phe Ser Glu Gly Val Val Asp Ser Val Lys Gly Gly Phe Ser 
            340                 345                 350         


Ser Phe Ser Gln Ala Thr His Ser Ala Ala Gly Ala Val Val Ser Lys 
        355                 360                 365             


Pro Arg Glu Ile Ala Ser Leu Ile Arg Asn Lys Phe Gly Ser Ala Asp 
    370                 375                 380                 


Asn Ile Pro Asn Leu Lys Asp Ser Leu Glu Glu Gly Gln Val Asp Asp 
385                 390                 395                 400 


Ala Gly Lys Ala Leu Gly Val Ile Ser Asn Phe Gln Ser Ser Pro Lys 
                405                 410                 415     


Tyr Gly Ser Glu Glu Asp Cys Ser Ser Ala Thr Ser Gly Ser Val Gly 
            420                 425                 430         


Ala Asn Ser Thr Thr Gly Gly Ile Ala Val Gly Ala Ser Ser Ser Lys 
        435                 440                 445             


Thr Asn Thr Leu Asp Met Gln Ser Ser Gly Phe Asp Ala Leu Leu His 
    450                 455                 460                 


Glu Ile Gln Glu Ile Arg Glu Thr Gln Ala Arg Leu Glu Glu Ser Phe 
465                 470                 475                 480 


Glu Thr Leu Lys Glu His Tyr Gln Arg Asp Tyr Ser Leu Ile Met Gln 
                485                 490                 495     


Thr Leu Gln Glu Glu Arg Tyr Arg Cys Glu Arg Leu Glu Glu Gln Leu 
            500                 505                 510         


Asn Asp Leu Thr Glu Leu His Gln Asn Glu Ile Leu Asn Leu Lys Gln 
        515                 520                 525             


Glu Leu Ala Ser Met Glu Glu Lys Ile Ala Tyr Gln Ser Tyr Glu Arg 
    530                 535                 540                 


Ala Arg Asp Ile Gln Glu Ala Leu Glu Ala Cys Gln Thr Arg Ile Ser 
545                 550                 555                 560 


Lys Met Glu Leu Gln Gln Gln Gln Gln Gln Val Val Gln Leu Glu Gly 
                565                 570                 575     


Leu Glu Asn Ala Thr Ala Arg Asn Leu Leu Gly Lys Leu Ile Asn Ile 
            580                 585                 590         


Leu Leu Ala Val Met Ala Val Leu Leu Val Phe Val Ser Thr Val Ala 
        595                 600                 605             


Asn Cys Val Val Pro Leu Met Lys Thr Arg Asn Arg Thr Phe Ser Thr 
    610                 615                 620                 


Leu Phe Leu Val Val Phe Ile Ala Phe Leu Trp Lys His Trp Asp Ala 
625                 630                 635                 640 


Leu Phe Ser Tyr Val Glu Arg Phe Phe Ser Ser Pro Arg 
                645                 650             


<210>  4026
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  4026

Met Ala Lys Gly Arg Val Ala Glu Arg Ser Gln Leu Gly Ala His His 
1               5                   10                  15      


Thr Thr Pro Val Gly Asp Gly Ala Ala Gly Thr Arg Gly Leu Ala Ala 
            20                  25                  30          


Pro Gly Ser Arg Asp His Gln Lys Glu Lys Ser Trp Val Glu Ala Gly 
        35                  40                  45              


Ser Ala Arg Met Ser Leu Leu Ile Leu Val Ser Ile Phe Leu Ser Ala 
    50                  55                  60                  


Ala Phe Val Met Phe Leu Val Tyr Lys Asn Phe Pro Gln Leu Ser Glu 
65                  70                  75                  80  


Glu Glu Arg Val Asn Met Lys Val Pro Arg Asp Met Asp Asp Ala Lys 
                85                  90                  95      


Ala Leu Gly Lys Val Leu Ser Lys Tyr Lys Asp Thr Phe Tyr Val Gln 
            100                 105                 110         


Val Leu Val Ala Tyr Phe Ala Thr Tyr Ile Phe Leu Gln Thr Phe Ala 
        115                 120                 125             


Ile Pro Gly Ser Ile Phe Leu Ser Ile Leu Ser Gly Phe Leu Tyr Pro 
    130                 135                 140                 


Phe Pro Leu Ala Leu Phe Leu Val Cys Leu Cys Ser Gly Leu Gly Ala 
145                 150                 155                 160 


Ser Phe Cys Tyr Met Leu Ser Tyr Leu Val Gly Arg Pro Val Val Tyr 
                165                 170                 175     


Lys Tyr Leu Thr Glu Lys Ala Val Lys Trp Ser Gln Gln Val Glu Arg 
            180                 185                 190         


His Arg Glu His Leu Ile Asn Tyr Ile Ile Phe Leu Arg Ile Thr Pro 
        195                 200                 205             


Phe Leu Pro Asn Trp Phe Ile Asn Ile Thr Ser Pro Val Ile Asn Val 
    210                 215                 220                 


Pro Leu Lys Val Phe Phe Ile Gly Thr Phe Leu Gly Val Ala Pro Pro 
225                 230                 235                 240 


Ser Phe Val Ala Ile Lys Ala Gly Thr Thr Leu Tyr Gln Leu Thr Thr 
                245                 250                 255     


Ala Gly Glu Ala Val Ser Trp Asn Ser Ile Phe Ile Leu Met Ile Leu 
            260                 265                 270         


Ala Val Leu Ser Ile Leu Pro Ala Ile Phe Gln Lys Lys Leu Lys Gln 
        275                 280                 285             


Lys Phe Glu 
    290     


<210>  4027
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  4027

Met Gly Thr Ala Arg Trp Leu Ala Leu Gly Ser Leu Phe Ala Leu Ala 
1               5                   10                  15      


Gly Leu Leu Glu Gly Arg Leu Val Gly Glu Glu Glu Ala Gly Phe Gly 
            20                  25                  30          


Glu Cys Asp Lys Phe Phe Tyr Ala Gly Thr Pro Pro Ala Gly Leu Ala 
        35                  40                  45              


Ala Asp Ser His Val Lys Ile Cys Gln Arg Ala Glu Gly Ala Glu Arg 
    50                  55                  60                  


Phe Ala Thr Leu Tyr Ser Thr Arg Asp Arg Ile Pro Val Tyr Ser Ala 
65                  70                  75                  80  


Phe Arg Ala Pro Arg Pro Ala Pro Gly Gly Ala Glu Gln Arg Trp Leu 
                85                  90                  95      


Val Glu Pro Gln Ile Asp Asp Pro Asn Ser Asn Leu Glu Glu Ala Ile 
            100                 105                 110         


Asn Glu Ala Glu Ala Ile Thr Ser Val Asn Ser Leu Gly Ser Lys Gln 
        115                 120                 125             


Ala Leu Asn Thr Asp Tyr Leu Asp Ser Asp Tyr Gln Arg Gly Gln Leu 
    130                 135                 140                 


Tyr Pro Phe Ser Leu Ser Ser Asp Val Gln Val Ala Thr Phe Thr Leu 
145                 150                 155                 160 


Thr Asn Ser Ala Pro Met Thr Gln Ser Phe Gln Glu Arg Trp Tyr Val 
                165                 170                 175     


Asn Leu His Ser Leu Met Asp Arg Ala Leu Thr Pro Gln Cys Gly Ser 
            180                 185                 190         


Gly Glu Asp Leu Tyr Ile Leu Thr Gly Thr Val Pro Ser Asp Tyr Arg 
        195                 200                 205             


Val Lys Asp Lys Val Ala Val Pro Glu Phe Val Trp Leu Ala Ala Cys 
    210                 215                 220                 


Cys Ala Val Pro Gly Gly Gly Trp Ala Met Gly Phe Val Lys His Thr 
225                 230                 235                 240 


Arg Asp Ser Asp Ile Ile Glu Asp Val Met Val Lys Asp Leu Gln Lys 
                245                 250                 255     


Leu Leu Pro Phe Asn Pro Gln Leu Phe Gln Asn Asn Cys Gly Glu Thr 
            260                 265                 270         


Glu Gln Asp Thr Glu Lys Met Lys Lys Ile Leu Glu Val Val Asn Gln 
        275                 280                 285             


Ile Gln Asp Glu Glu Arg Met Val Gln Ser Gln Lys Ser Ser Ser Pro 
    290                 295                 300                 


Leu Ser Ser Thr Arg Ser Lys Arg Ser Thr Leu Leu Pro Pro Glu Ala 
305                 310                 315                 320 


Ser Glu Gly Ser Ser Ser Phe Leu Gly Lys Leu Met Gly Phe Ile Ala 
                325                 330                 335     


Thr Pro Phe Ile Lys Leu Phe Gln Leu Ile Tyr Tyr Leu Val Val Ala 
            340                 345                 350         


Ile Leu Lys Asn Ile Val Tyr Phe Leu Trp Cys Val Thr Lys Gln Val 
        355                 360                 365             


Ile Asn Gly Ile Glu Ser Cys Leu Tyr Arg Leu Gly Ser Ala Thr Ile 
    370                 375                 380                 


Ser Tyr Phe Met Ala Ile Gly Glu Glu Leu Val Ser Ile Pro Trp Lys 
385                 390                 395                 400 


Val Leu Lys Val Val Ala Lys Val Ile Arg Ala Leu Leu Arg Ile Leu 
                405                 410                 415     


Cys Cys Leu Leu Lys Ala Ile Cys Arg Val Leu Ser Ile Pro Val Arg 
            420                 425                 430         


Val Leu Val Asp Val Ala Thr Phe Pro Val Tyr Thr Met Gly Ala Ile 
        435                 440                 445             


Pro Ile Val Cys Lys Asp Ile Ala Leu Gly Leu Gly Gly Thr Val Ser 
    450                 455                 460                 


Leu Leu Phe Asp Thr Ala Phe Gly Thr Leu Gly Gly Leu Phe Gln Val 
465                 470                 475                 480 


Val Phe Ser Val Cys Lys Arg Ile Gly Tyr Lys Val Thr Phe Asp Asn 
                485                 490                 495     


Ser Gly Glu Leu 
            500 


<210>  4028
<211>  921
<212>  PRT
<213>  Homo sapiens

<400>  4028

Met Ala Pro Leu Ala Leu Val Gly Val Thr Leu Leu Leu Ala Ala Pro 
1               5                   10                  15      


Pro Cys Ser Gly Ala Ala Thr Pro Thr Pro Ser Leu Pro Pro Pro Pro 
            20                  25                  30          


Ala Asn Asp Ser Asp Thr Ser Thr Gly Gly Cys Gln Gly Ser Tyr Arg 
        35                  40                  45              


Cys Gln Pro Gly Val Leu Leu Pro Val Trp Glu Pro Asp Asp Pro Ser 
    50                  55                  60                  


Leu Gly Asp Lys Ala Ala Arg Ala Val Val Tyr Phe Val Ala Met Val 
65                  70                  75                  80  


Tyr Met Phe Leu Gly Val Ser Ile Ile Ala Asp Arg Phe Met Ala Ala 
                85                  90                  95      


Ile Glu Val Ile Thr Ser Lys Glu Lys Glu Ile Thr Ile Thr Lys Ala 
            100                 105                 110         


Asn Gly Glu Thr Ser Val Gly Thr Val Arg Ile Trp Asn Glu Thr Val 
        115                 120                 125             


Ser Asn Leu Thr Leu Met Ala Leu Gly Ser Ser Ala Pro Glu Ile Leu 
    130                 135                 140                 


Leu Ser Val Ile Glu Val Cys Gly His Asn Phe Gln Ala Gly Glu Leu 
145                 150                 155                 160 


Gly Pro Gly Thr Ile Val Gly Ser Ala Ala Phe Asn Met Phe Val Val 
                165                 170                 175     


Ile Ala Val Cys Ile Tyr Val Ile Pro Ala Gly Glu Ser Arg Lys Ile 
            180                 185                 190         


Lys His Leu Arg Val Phe Phe Val Thr Ala Ser Trp Ser Ile Phe Ala 
        195                 200                 205             


Tyr Val Trp Leu Tyr Leu Ile Leu Ala Val Phe Ser Pro Gly Val Val 
    210                 215                 220                 


Gln Val Trp Glu Ala Leu Leu Thr Leu Val Phe Phe Pro Val Cys Val 
225                 230                 235                 240 


Val Phe Ala Trp Met Ala Asp Lys Arg Leu Leu Phe Tyr Lys Tyr Val 
                245                 250                 255     


Tyr Lys Arg Tyr Arg Thr Asp Pro Arg Ser Gly Ile Ile Ile Gly Ala 
            260                 265                 270         


Glu Gly Asp Pro Pro Lys Ser Ile Glu Leu Asp Gly Thr Phe Val Gly 
        275                 280                 285             


Ala Glu Ala Pro Gly Glu Leu Gly Gly Leu Gly Pro Gly Pro Ala Glu 
    290                 295                 300                 


Ala Arg Glu Leu Asp Ala Ser Arg Arg Glu Val Ile Gln Ile Leu Lys 
305                 310                 315                 320 


Asp Leu Lys Gln Lys His Pro Asp Lys Asp Leu Glu Gln Leu Val Gly 
                325                 330                 335     


Ile Ala Asn Tyr Tyr Ala Leu Leu His Gln Gln Lys Ser Arg Ala Phe 
            340                 345                 350         


Tyr Arg Ile Gln Ala Thr Arg Leu Met Thr Gly Ala Gly Asn Val Leu 
        355                 360                 365             


Arg Arg His Ala Ala Asp Ala Ser Arg Arg Ala Ala Pro Ala Glu Gly 
    370                 375                 380                 


Ala Gly Glu Asp Glu Asp Asp Gly Ala Ser Arg Ile Phe Phe Glu Pro 
385                 390                 395                 400 


Ser Leu Tyr His Cys Leu Glu Asn Cys Gly Ser Val Leu Leu Ser Val 
                405                 410                 415     


Thr Cys Gln Gly Gly Glu Gly Asn Ser Thr Phe Tyr Val Asp Tyr Arg 
            420                 425                 430         


Thr Glu Asp Gly Ser Ala Lys Ala Gly Ser Asp Tyr Glu Tyr Ser Glu 
        435                 440                 445             


Gly Thr Leu Val Phe Lys Pro Gly Glu Thr Gln Lys Glu Leu Arg Ile 
    450                 455                 460                 


Gly Ile Ile Asp Asp Asp Ile Phe Glu Glu Asp Glu His Phe Phe Val 
465                 470                 475                 480 


Arg Leu Leu Asn Leu Arg Val Gly Asp Ala Gln Gly Met Phe Glu Pro 
                485                 490                 495     


Asp Gly Gly Gly Arg Pro Lys Gly Arg Leu Val Ala Pro Leu Leu Ala 
            500                 505                 510         


Thr Val Thr Ile Leu Asp Asp Asp His Ala Gly Ile Phe Ser Phe Gln 
        515                 520                 525             


Asp Arg Leu Leu His Val Ser Glu Cys Met Gly Thr Val Asp Val Arg 
    530                 535                 540                 


Val Val Arg Ser Ser Gly Ala Arg Gly Thr Val Arg Leu Pro Tyr Arg 
545                 550                 555                 560 


Thr Val Asp Gly Thr Ala Arg Gly Gly Gly Val His Tyr Glu Asp Ala 
                565                 570                 575     


Cys Gly Glu Leu Glu Phe Gly Asp Asp Glu Thr Met Lys Thr Leu Gln 
            580                 585                 590         


Val Lys Ile Val Asp Asp Glu Glu Tyr Glu Lys Lys Asp Asn Phe Phe 
        595                 600                 605             


Ile Glu Leu Gly Gln Pro Gln Trp Leu Lys Arg Gly Ile Ser Ala Leu 
    610                 615                 620                 


Leu Leu Asn Gln Gly Asp Gly Asp Arg Lys Leu Thr Ala Glu Glu Glu 
625                 630                 635                 640 


Glu Ala Arg Arg Ile Ala Glu Met Gly Lys Pro Val Leu Gly Glu Asn 
                645                 650                 655     


Cys Arg Leu Glu Val Ile Ile Glu Glu Ser Tyr Asp Phe Lys Asn Thr 
            660                 665                 670         


Val Asp Lys Leu Ile Lys Lys Thr Asn Leu Ala Leu Val Ile Gly Thr 
        675                 680                 685             


His Ser Trp Arg Glu Gln Phe Leu Glu Ala Ile Thr Val Ser Ala Gly 
    690                 695                 700                 


Asp Glu Glu Glu Glu Glu Asp Gly Ser Arg Glu Glu Arg Leu Pro Ser 
705                 710                 715                 720 


Cys Phe Asp Tyr Val Met His Phe Leu Thr Val Phe Trp Lys Val Leu 
                725                 730                 735     


Phe Ala Cys Val Pro Pro Thr Glu Tyr Cys His Gly Trp Ala Cys Phe 
            740                 745                 750         


Gly Val Ser Ile Leu Val Ile Gly Leu Leu Thr Ala Leu Ile Gly Asp 
        755                 760                 765             


Leu Ala Ser His Phe Gly Cys Thr Val Gly Leu Lys Asp Ser Val Asn 
    770                 775                 780                 


Ala Val Val Phe Val Ala Leu Gly Thr Ser Ile Pro Asp Thr Phe Ala 
785                 790                 795                 800 


Ser Lys Val Ala Ala Leu Gln Asp Gln Cys Ala Asp Ala Ser Ile Gly 
                805                 810                 815     


Asn Val Thr Gly Ser Asn Ala Val Asn Val Phe Leu Gly Leu Gly Val 
            820                 825                 830         


Ala Trp Ser Val Ala Ala Val Tyr Trp Ala Val Gln Gly Arg Pro Phe 
        835                 840                 845             


Glu Val Arg Thr Gly Thr Leu Ala Phe Ser Val Thr Leu Phe Thr Val 
    850                 855                 860                 


Phe Ala Phe Val Gly Ile Ala Val Leu Leu Tyr Arg Arg Arg Pro His 
865                 870                 875                 880 


Ile Gly Gly Glu Leu Gly Gly Pro Arg Gly Pro Lys Leu Ala Thr Thr 
                885                 890                 895     


Ala Leu Phe Leu Gly Leu Trp Leu Leu Tyr Ile Leu Phe Ala Ser Leu 
            900                 905                 910         


Glu Ala Tyr Cys His Ile Arg Gly Phe 
        915                 920     


<210>  4029
<211>  914
<212>  PRT
<213>  Homo sapiens

<400>  4029

Met Pro Gly Ala Gly Ala Arg Ala Glu Glu Gly Gly Gly Gly Gly Glu 
1               5                   10                  15      


Gly Ala Ala Gln Gly Ala Ala Ala Glu Pro Gly Ala Gly Pro Ala Arg 
            20                  25                  30          


Glu Pro Ala Arg Leu Cys Gly Tyr Leu Gln Lys Leu Ser Gly Lys Gly 
        35                  40                  45              


Pro Leu Arg Gly Tyr Arg Ser Arg Trp Phe Val Phe Asp Ala Arg Arg 
    50                  55                  60                  


Cys Tyr Leu Tyr Tyr Phe Lys Ser Pro Gln Asp Ala Leu Pro Leu Gly 
65                  70                  75                  80  


His Leu Asp Ile Ala Asp Ala Cys Phe Ser Tyr Gln Gly Pro Asp Glu 
                85                  90                  95      


Ala Ala Glu Pro Gly Thr Glu Pro Pro Ala His Phe Gln Val His Ser 
            100                 105                 110         


Ala Gly Ala Val Thr Val Leu Lys Ala Pro Asn Arg Gln Leu Met Thr 
        115                 120                 125             


Tyr Trp Leu Gln Glu Leu Gln Gln Lys Arg Trp Glu Tyr Cys Asn Ser 
    130                 135                 140                 


Leu Asp Met Val Lys Trp Asp Ser Arg Thr Ser Pro Thr Pro Gly Asp 
145                 150                 155                 160 


Phe Pro Lys Gly Leu Val Ala Arg Asp Asn Thr Asp Leu Ile Tyr Pro 
                165                 170                 175     


His Pro Asn Ala Ser Ala Glu Lys Ala Arg Asn Val Leu Ala Val Glu 
            180                 185                 190         


Thr Val Pro Gly Glu Leu Val Gly Glu Gln Ala Ala Asn Gln Pro Ala 
        195                 200                 205             


Pro Gly His Pro Asn Ser Ile Asn Phe Tyr Ser Leu Lys Gln Trp Gly 
    210                 215                 220                 


Asn Glu Leu Lys Asn Ser Met Ser Ser Phe Arg Pro Gly Arg Gly His 
225                 230                 235                 240 


Asn Asp Ser Arg Arg Thr Val Phe Tyr Thr Asn Glu Glu Trp Glu Leu 
                245                 250                 255     


Leu Asp Pro Thr Pro Lys Asp Leu Glu Glu Ser Ile Val Gln Glu Glu 
            260                 265                 270         


Lys Lys Lys Leu Thr Pro Glu Gly Asn Lys Gly Val Thr Gly Ser Gly 
        275                 280                 285             


Phe Pro Phe Asp Phe Gly Arg Asn Pro Tyr Lys Gly Lys Arg Pro Leu 
    290                 295                 300                 


Lys Asp Ile Ile Gly Ser Tyr Lys Asn Arg His Ser Ser Gly Asp Pro 
305                 310                 315                 320 


Ser Ser Glu Gly Thr Ser Gly Ser Gly Ser Val Ser Ile Arg Lys Pro 
                325                 330                 335     


Ala Ser Glu Met Gln Leu Gln Val Gln Ser Gln Gln Glu Glu Leu Glu 
            340                 345                 350         


Gln Leu Lys Lys Asp Leu Ser Ser Gln Lys Glu Leu Val Arg Leu Leu 
        355                 360                 365             


Gln Gln Thr Val Arg Ser Ser Gln Tyr Asp Lys Tyr Phe Thr Ser Ser 
    370                 375                 380                 


Arg Leu Cys Glu Gly Val Pro Lys Asp Thr Leu Glu Leu Leu His Gln 
385                 390                 395                 400 


Lys Asp Asp Gln Ile Leu Gly Leu Thr Ser Gln Leu Glu Arg Phe Ser 
                405                 410                 415     


Leu Glu Lys Glu Ser Leu Gln Gln Glu Val Arg Thr Leu Lys Ser Lys 
            420                 425                 430         


Val Gly Glu Leu Asn Glu Gln Leu Gly Met Leu Met Glu Thr Ile Gln 
        435                 440                 445             


Ala Lys Asp Glu Val Ile Ile Lys Leu Ser Glu Gly Glu Gly Asn Gly 
    450                 455                 460                 


Pro Pro Pro Thr Val Ala Pro Ser Ser Pro Ser Val Val Pro Val Ala 
465                 470                 475                 480 


Arg Asp Gln Leu Glu Leu Asp Arg Leu Lys Asp Asn Leu Gln Gly Tyr 
                485                 490                 495     


Lys Thr Gln Asn Lys Phe Leu Asn Lys Glu Ile Leu Glu Leu Ser Ala 
            500                 505                 510         


Leu Arg Arg Asn Ala Glu Arg Arg Glu Arg Asp Leu Met Ala Lys Tyr 
        515                 520                 525             


Ser Ser Leu Glu Ala Lys Leu Cys Gln Ile Glu Ser Lys Tyr Leu Ile 
    530                 535                 540                 


Leu Leu Gln Glu Met Lys Thr Pro Val Cys Ser Glu Asp Gln Gly Pro 
545                 550                 555                 560 


Thr Arg Glu Val Ile Ala Gln Leu Leu Glu Asp Ala Leu Gln Val Glu 
                565                 570                 575     


Ser Gln Glu Gln Pro Glu Gln Ala Phe Val Lys Pro His Leu Val Ser 
            580                 585                 590         


Glu Tyr Asp Ile Tyr Gly Phe Arg Thr Val Pro Glu Asp Asp Glu Glu 
        595                 600                 605             


Glu Lys Leu Val Ala Lys Val Arg Ala Leu Asp Leu Lys Thr Leu Tyr 
    610                 615                 620                 


Leu Thr Glu Asn Gln Glu Val Ser Thr Gly Val Lys Trp Glu Asn Tyr 
625                 630                 635                 640 


Phe Ala Ser Thr Val Asn Arg Glu Met Met Cys Ser Pro Glu Leu Lys 
                645                 650                 655     


Asn Leu Ile Arg Ala Gly Ile Pro His Glu His Arg Ser Lys Val Trp 
            660                 665                 670         


Lys Trp Cys Val Asp Arg His Thr Arg Lys Phe Lys Asp Asn Thr Glu 
        675                 680                 685             


Pro Gly His Phe Gln Thr Leu Leu Gln Lys Ala Leu Glu Lys Gln Asn 
    690                 695                 700                 


Pro Ala Ser Lys Gln Ile Glu Leu Asp Leu Leu Arg Thr Leu Pro Asn 
705                 710                 715                 720 


Asn Lys His Tyr Ser Cys Pro Thr Ser Glu Gly Ile Gln Lys Leu Arg 
                725                 730                 735     


Asn Val Leu Leu Ala Phe Ser Trp Arg Asn Pro Asp Ile Gly Tyr Cys 
            740                 745                 750         


Gln Gly Leu Asn Arg Leu Val Ala Val Ala Leu Leu Tyr Leu Glu Gln 
        755                 760                 765             


Glu Asp Ala Phe Trp Cys Leu Val Thr Ile Val Glu Val Phe Met Pro 
    770                 775                 780                 


Arg Asp Tyr Tyr Thr Lys Thr Leu Leu Gly Ser Gln Val Asp Gln Arg 
785                 790                 795                 800 


Val Phe Arg Asp Leu Met Ser Glu Lys Leu Pro Arg Leu His Gly His 
                805                 810                 815     


Phe Glu Gln Tyr Lys Val Asp Tyr Thr Leu Ile Thr Phe Asn Trp Phe 
            820                 825                 830         


Leu Val Val Phe Val Asp Ser Val Val Ser Asp Ile Leu Phe Lys Ile 
        835                 840                 845             


Trp Asp Ser Phe Leu Tyr Glu Gly Pro Lys Val Ile Phe Arg Phe Ala 
    850                 855                 860                 


Leu Ala Leu Phe Lys Tyr Lys Glu Glu Glu Ile Leu Lys Leu Gln Asp 
865                 870                 875                 880 


Ser Met Ser Ile Phe Lys Tyr Leu Arg Tyr Phe Thr Arg Thr Ile Leu 
                885                 890                 895     


Asp Ala Arg Ser Gly Thr Asp Ala Pro Thr Thr Trp Arg Lys Ser Gly 
            900                 905                 910         


Trp Ser 
        


<210>  4030
<211>  1712
<212>  PRT
<213>  Homo sapiens

<400>  4030

Met Ala Ser Gly Ser Arg Trp Arg Pro Thr Pro Pro Pro Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ala Leu Ala Ala Arg Ala Asp Gly Leu Glu Phe Gly 
            20                  25                  30          


Gly Gly Pro Gly Gln Trp Ala Arg Tyr Ala Arg Trp Ala Gly Ala Ala 
        35                  40                  45              


Ser Ser Gly Glu Leu Ser Phe Ser Leu Arg Thr Asn Ala Thr Arg Ala 
    50                  55                  60                  


Leu Leu Leu Tyr Leu Asp Asp Gly Gly Asp Cys Asp Phe Leu Glu Leu 
65                  70                  75                  80  


Leu Leu Val Asp Gly Arg Leu Arg Leu Arg Phe Thr Leu Ser Cys Ala 
                85                  90                  95      


Glu Pro Ala Thr Leu Gln Leu Asp Thr Pro Val Ala Asp Asp Arg Trp 
            100                 105                 110         


His Met Val Leu Leu Thr Arg Asp Ala Arg Arg Thr Ala Leu Ala Val 
        115                 120                 125             


Asp Gly Glu Ala Arg Ala Ala Glu Val Arg Ser Lys Arg Arg Glu Met 
    130                 135                 140                 


Gln Val Ala Ser Asp Leu Phe Val Gly Gly Ile Pro Pro Asp Val Arg 
145                 150                 155                 160 


Leu Ser Ala Leu Thr Leu Ser Thr Val Lys Tyr Glu Pro Pro Phe Arg 
                165                 170                 175     


Gly Leu Leu Ala Asn Leu Lys Leu Gly Glu Arg Pro Pro Ala Leu Leu 
            180                 185                 190         


Gly Ser Gln Gly Leu Arg Gly Ala Thr Ala Asp Pro Leu Cys Ala Pro 
        195                 200                 205             


Ala Arg Asn Pro Cys Ala Asn Gly Gly Leu Cys Thr Val Leu Ala Pro 
    210                 215                 220                 


Gly Glu Val Gly Cys Asp Cys Ser His Thr Gly Phe Gly Gly Lys Phe 
225                 230                 235                 240 


Cys Ser Glu Glu Glu His Pro Met Glu Gly Pro Ala His Leu Thr Leu 
                245                 250                 255     


Asn Ser Glu Val Gly Ser Leu Leu Phe Ser Glu Gly Gly Ala Gly Arg 
            260                 265                 270         


Gly Gly Ala Gly Asp Val His Gln Pro Thr Lys Gly Lys Glu Glu Phe 
        275                 280                 285             


Val Ala Thr Phe Lys Gly Asn Glu Phe Phe Cys Tyr Asp Leu Ser His 
    290                 295                 300                 


Asn Pro Ile Gln Ser Ser Thr Asp Glu Ile Thr Leu Ala Phe Arg Thr 
305                 310                 315                 320 


Leu Gln Arg Asn Gly Leu Met Leu His Thr Gly Lys Ser Ala Asp Tyr 
                325                 330                 335     


Val Asn Leu Ser Leu Lys Ser Gly Ala Val Trp Leu Val Ile Asn Leu 
            340                 345                 350         


Gly Ser Gly Ala Phe Glu Ala Leu Val Glu Pro Val Asn Gly Lys Phe 
        355                 360                 365             


Asn Asp Asn Ala Trp His Asp Val Arg Val Thr Arg Asn Leu Arg Gln 
    370                 375                 380                 


His Ala Gly Ile Gly His Ala Met Val Asn Lys Leu His Tyr Leu Val 
385                 390                 395                 400 


Thr Ile Ser Val Asp Gly Ile Leu Thr Thr Thr Gly Tyr Thr Gln Glu 
                405                 410                 415     


Asp Tyr Thr Met Leu Gly Ser Asp Asp Phe Phe Tyr Ile Gly Gly Ser 
            420                 425                 430         


Pro Asn Thr Ala Asp Leu Pro Gly Ser Pro Val Ser Asn Asn Phe Met 
        435                 440                 445             


Gly Cys Leu Lys Asp Val Val Tyr Lys Asn Asn Asp Phe Lys Leu Glu 
    450                 455                 460                 


Leu Ser Arg Leu Ala Lys Glu Gly Asp Pro Lys Met Lys Leu Gln Gly 
465                 470                 475                 480 


Asp Leu Ser Phe Arg Cys Glu Asp Val Ala Ala Leu Asp Pro Val Thr 
                485                 490                 495     


Phe Glu Ser Pro Glu Ala Phe Val Ala Leu Pro Arg Trp Ser Ala Lys 
            500                 505                 510         


Arg Thr Gly Ser Ile Ser Leu Asp Phe Arg Thr Thr Glu Pro Asn Gly 
        515                 520                 525             


Leu Leu Leu Phe Ser Gln Gly Arg Arg Ala Gly Gly Gly Ala Gly Ser 
    530                 535                 540                 


His Ser Ser Ala Gln Arg Ala Asp Tyr Phe Ala Met Glu Leu Leu Asp 
545                 550                 555                 560 


Gly His Leu Tyr Leu Leu Leu Asp Met Gly Ser Gly Gly Ile Lys Leu 
                565                 570                 575     


Arg Ala Ser Ser Arg Lys Val Asn Asp Gly Glu Trp Cys His Val Asp 
            580                 585                 590         


Phe Gln Arg Asp Gly Arg Lys Gly Ser Ile Ser Val Asn Ser Arg Ser 
        595                 600                 605             


Thr Pro Phe Leu Ala Thr Gly Asp Ser Glu Ile Leu Asp Leu Glu Ser 
    610                 615                 620                 


Glu Leu Tyr Leu Gly Gly Leu Pro Glu Gly Gly Arg Val Asp Leu Pro 
625                 630                 635                 640 


Leu Pro Pro Glu Val Trp Thr Ala Ala Leu Arg Ala Gly Tyr Val Gly 
                645                 650                 655     


Cys Val Arg Asp Leu Phe Ile Asp Gly Arg Ser Arg Asp Leu Arg Gly 
            660                 665                 670         


Leu Ala Glu Ala Gln Gly Ala Val Gly Val Ala Pro Phe Cys Ser Arg 
        675                 680                 685             


Glu Thr Leu Lys Gln Cys Ala Ser Ala Pro Cys Arg Asn Gly Gly Val 
    690                 695                 700                 


Cys Arg Glu Gly Trp Asn Arg Phe Ile Cys Asp Cys Ile Gly Thr Gly 
705                 710                 715                 720 


Phe Leu Gly Arg Val Cys Glu Arg Glu Ala Thr Val Leu Ser Tyr Asp 
                725                 730                 735     


Gly Ser Met Tyr Met Lys Ile Met Leu Pro Asn Ala Met His Thr Glu 
            740                 745                 750         


Ala Glu Asp Val Ser Leu Arg Phe Met Ser Gln Arg Ala Tyr Gly Leu 
        755                 760                 765             


Met Met Ala Thr Thr Ser Arg Glu Ser Ala Asp Thr Leu Arg Leu Glu 
    770                 775                 780                 


Leu Asp Gly Gly Gln Met Lys Leu Thr Val Asn Leu Asp Cys Leu Arg 
785                 790                 795                 800 


Val Gly Cys Ala Pro Ser Lys Gly Pro Glu Thr Leu Phe Ala Gly His 
                805                 810                 815     


Lys Leu Asn Asp Asn Glu Trp His Thr Val Arg Val Val Arg Arg Gly 
            820                 825                 830         


Lys Ser Leu Gln Leu Ser Val Asp Asn Val Thr Val Glu Gly Gln Met 
        835                 840                 845             


Ala Gly Ala His Met Arg Leu Glu Phe His Asn Ile Glu Thr Gly Ile 
    850                 855                 860                 


Met Thr Glu Arg Arg Phe Ile Ser Val Val Pro Ser Asn Phe Ile Gly 
865                 870                 875                 880 


His Leu Ser Gly Leu Val Phe Asn Gly Gln Pro Tyr Met Asp Gln Cys 
                885                 890                 895     


Lys Asp Gly Asp Ile Thr Tyr Cys Glu Leu Asn Ala Arg Phe Gly Leu 
            900                 905                 910         


Arg Ala Ile Val Ala Asp Pro Val Thr Phe Lys Ser Arg Ser Ser Tyr 
        915                 920                 925             


Leu Ala Leu Ala Thr Leu Gln Ala Tyr Ala Ser Met His Leu Phe Phe 
    930                 935                 940                 


Gln Phe Lys Thr Thr Ala Pro Asp Gly Leu Leu Leu Phe Asn Ser Gly 
945                 950                 955                 960 


Asn Gly Asn Asp Phe Ile Val Ile Glu Leu Val Lys Gly Tyr Ile His 
                965                 970                 975     


Tyr Val Phe Asp Leu Gly Asn Gly Pro Ser Leu Met Lys Gly Asn Ser 
            980                 985                 990         


Asp Lys Pro Val Asn Asp Asn Gln  Trp His Asn Val Val  Val Ser Arg 
        995                 1000                 1005             


Asp Pro  Gly Asn Val His Thr  Leu Lys Ile Asp Ser  Arg Thr Val 
    1010                 1015                 1020             


Thr Gln  His Ser Asn Gly Ala  Arg Asn Leu Asp Leu  Lys Gly Glu 
    1025                 1030                 1035             


Leu Tyr  Ile Gly Gly Leu Ser  Lys Asn Met Phe Ser  Asn Leu Pro 
    1040                 1045                 1050             


Lys Leu  Val Ala Ser Arg Asp  Gly Phe Gln Gly Cys  Leu Ala Ser 
    1055                 1060                 1065             


Val Asp  Leu Asn Gly Arg Leu  Pro Asp Leu Ile Ala  Asp Ala Leu 
    1070                 1075                 1080             


His Arg  Ile Gly Gln Val Glu  Arg Gly Cys Asp Gly  Pro Ser Thr 
    1085                 1090                 1095             


Thr Cys  Thr Glu Glu Ser Cys  Ala Asn Gln Gly Val  Cys Leu Gln 
    1100                 1105                 1110             


Gln Trp  Asp Gly Phe Thr Cys  Asp Cys Thr Met Thr  Ser Tyr Gly 
    1115                 1120                 1125             


Gly Pro  Val Cys Asn Asp Pro  Gly Thr Thr Tyr Ile  Phe Gly Lys 
    1130                 1135                 1140             


Gly Gly  Ala Leu Ile Thr Tyr  Thr Trp Pro Pro Asn  Asp Arg Pro 
    1145                 1150                 1155             


Ser Thr  Arg Met Asp Arg Leu  Ala Val Gly Phe Ser  Thr His Gln 
    1160                 1165                 1170             


Arg Ser  Ala Val Leu Val Arg  Val Asp Ser Ala Ser  Gly Leu Gly 
    1175                 1180                 1185             


Asp Tyr  Leu Gln Leu His Ile  Asp Gln Gly Thr Val  Gly Val Ile 
    1190                 1195                 1200             


Phe Asn  Val Gly Thr Asp Asp  Ile Thr Ile Asp Glu  Pro Asn Ala 
    1205                 1210                 1215             


Ile Val  Ser Asp Gly Lys Tyr  His Val Val Arg Phe  Thr Arg Ser 
    1220                 1225                 1230             


Gly Gly  Asn Ala Thr Leu Gln  Val Asp Ser Trp Pro  Val Asn Glu 
    1235                 1240                 1245             


Arg Tyr  Pro Ala Gly Asn Phe  Asp Asn Glu Arg Leu  Ala Ile Ala 
    1250                 1255                 1260             


Arg Gln  Arg Ile Pro Tyr Arg  Leu Gly Arg Val Val  Asp Glu Trp 
    1265                 1270                 1275             


Leu Leu  Asp Lys Gly Arg Gln  Leu Thr Ile Phe Asn  Ser Gln Ala 
    1280                 1285                 1290             


Ala Ile  Lys Ile Gly Gly Arg  Asp Gln Gly Arg Pro  Phe Gln Gly 
    1295                 1300                 1305             


Gln Val  Ser Gly Leu Tyr Tyr  Asn Gly Leu Lys Val  Leu Ala Leu 
    1310                 1315                 1320             


Ala Ala  Glu Ser Asp Pro Asn  Val Arg Thr Glu Gly  His Leu Arg 
    1325                 1330                 1335             


Leu Val  Gly Glu Gly Pro Ser  Val Leu Leu Ser Ala  Glu Thr Thr 
    1340                 1345                 1350             


Ala Thr  Thr Leu Leu Ala Asp  Met Ala Thr Thr Ile  Met Glu Thr 
    1355                 1360                 1365             


Thr Thr  Thr Met Ala Thr Thr  Thr Thr Arg Arg Gly  Arg Ser Pro 
    1370                 1375                 1380             


Thr Leu  Arg Asp Ser Thr Thr  Gln Asn Thr Asp Asp  Leu Leu Val 
    1385                 1390                 1395             


Ala Ser  Ala Glu Cys Pro Ser  Asp Asp Glu Asp Leu  Glu Glu Cys 
    1400                 1405                 1410             


Glu Pro  Ser Thr Gly Gly Glu  Leu Ile Leu Pro Ile  Ile Thr Glu 
    1415                 1420                 1425             


Asp Ser  Leu Asp Pro Pro Pro  Val Ala Thr Arg Ser  Pro Phe Val 
    1430                 1435                 1440             


Pro Pro  Pro Pro Thr Phe Tyr  Pro Phe Leu Thr Gly  Val Gly Ala 
    1445                 1450                 1455             


Thr Gln  Asp Thr Leu Pro Pro  Pro Ala Ala Arg Arg  Pro Pro Ser 
    1460                 1465                 1470             


Gly Gly  Pro Cys Gln Ala Glu  Arg Asp Asp Ser Asp  Cys Glu Glu 
    1475                 1480                 1485             


Pro Ile  Glu Ala Ser Gly Phe  Ala Ser Gly Glu Val  Phe Asp Ser 
    1490                 1495                 1500             


Ser Leu  Pro Pro Thr Asp Asp  Glu Asp Phe Tyr Thr  Thr Phe Pro 
    1505                 1510                 1515             


Leu Val  Thr Asp Arg Thr Thr  Leu Leu Ser Pro Arg  Lys Pro Ala 
    1520                 1525                 1530             


Pro Arg  Pro Asn Leu Arg Thr  Asp Gly Ala Thr Gly  Ala Pro Gly 
    1535                 1540                 1545             


Val Leu  Phe Ala Pro Ser Ala  Pro Ala Pro Asn Leu  Pro Ala Gly 
    1550                 1555                 1560             


Lys Met  Asn His Arg Asp Pro  Leu Gln Pro Leu Leu  Glu Asn Pro 
    1565                 1570                 1575             


Pro Leu  Gly Pro Gly Ala Pro  Thr Ser Phe Glu Pro  Arg Arg Pro 
    1580                 1585                 1590             


Pro Pro  Leu Arg Pro Gly Val  Thr Ser Ala Pro Gly  Phe Pro His 
    1595                 1600                 1605             


Leu Pro  Thr Ala Asn Pro Thr  Gly Pro Gly Glu Arg  Gly Pro Pro 
    1610                 1615                 1620             


Gly Ala  Val Glu Val Ile Arg  Glu Ser Ser Ser Thr  Thr Gly Met 
    1625                 1630                 1635             


Val Val  Gly Ile Val Ala Ala  Ala Ala Leu Cys Ile  Leu Ile Leu 
    1640                 1645                 1650             


Leu Tyr  Ala Met Tyr Lys Tyr  Arg Asn Arg Asp Glu  Gly Ser Tyr 
    1655                 1660                 1665             


Gln Val  Asp Gln Ser Arg Asn  Tyr Ile Ser Asn Ser  Ala Gln Ser 
    1670                 1675                 1680             


Asn Gly  Ala Val Val Lys Glu  Lys Ala Pro Ala Ala  Pro Lys Thr 
    1685                 1690                 1695             


Pro Ser  Lys Ala Lys Lys Asn  Lys Asp Lys Glu Tyr  Tyr Val 
    1700                 1705                 1710         


<210>  4031
<211>  1169
<212>  PRT
<213>  Homo sapiens

<400>  4031

Met Ala Arg Gln Pro Pro Pro Pro Trp Val His Ala Ala Phe Leu Leu 
1               5                   10                  15      


Cys Leu Leu Ser Leu Gly Gly Ala Ile Glu Ile Pro Met Asp Leu Thr 
            20                  25                  30          


Gln Pro Pro Thr Ile Thr Lys Gln Ser Ala Lys Asp His Ile Val Asp 
        35                  40                  45              


Pro Arg Asp Asn Ile Leu Ile Glu Cys Glu Ala Lys Gly Asn Pro Ala 
    50                  55                  60                  


Pro Ser Phe His Trp Thr Arg Asn Ser Arg Phe Phe Asn Ile Ala Lys 
65                  70                  75                  80  


Asp Pro Arg Val Ser Met Arg Arg Arg Ser Gly Thr Leu Val Ile Asp 
                85                  90                  95      


Phe Arg Ser Gly Gly Arg Pro Glu Glu Tyr Glu Gly Glu Tyr Gln Cys 
            100                 105                 110         


Phe Ala Arg Asn Lys Phe Gly Thr Ala Leu Ser Asn Arg Ile Arg Leu 
        115                 120                 125             


Gln Val Ser Lys Ser Pro Leu Trp Pro Lys Glu Asn Leu Asp Pro Val 
    130                 135                 140                 


Val Val Gln Glu Gly Ala Pro Leu Thr Leu Gln Cys Asn Pro Pro Pro 
145                 150                 155                 160 


Gly Leu Pro Ser Pro Val Ile Phe Trp Met Ser Ser Ser Met Glu Pro 
                165                 170                 175     


Ile Thr Gln Asp Lys Arg Val Ser Gln Gly His Asn Gly Asp Leu Tyr 
            180                 185                 190         


Phe Ser Asn Val Met Leu Gln Asp Met Gln Thr Asp Tyr Ser Cys Asn 
        195                 200                 205             


Ala Arg Phe His Phe Thr His Thr Ile Gln Gln Lys Asn Pro Phe Thr 
    210                 215                 220                 


Leu Lys Val Leu Thr Asn His Pro Tyr Asn Asp Ser Ser Leu Arg Asn 
225                 230                 235                 240 


His Pro Asp Met Tyr Ser Ala Arg Gly Val Ala Glu Arg Thr Pro Ser 
                245                 250                 255     


Phe Met Tyr Pro Gln Gly Thr Ala Ser Ser Gln Met Val Leu Arg Gly 
            260                 265                 270         


Met Asp Leu Leu Leu Glu Cys Ile Ala Ser Gly Val Pro Thr Pro Asp 
        275                 280                 285             


Ile Ala Trp Tyr Lys Lys Gly Gly Asp Leu Pro Ser Asp Lys Ala Lys 
    290                 295                 300                 


Phe Glu Asn Phe Asn Lys Ala Leu Arg Ile Thr Asn Val Ser Glu Glu 
305                 310                 315                 320 


Asp Ser Gly Glu Tyr Phe Cys Leu Ala Ser Asn Lys Met Gly Ser Ile 
                325                 330                 335     


Arg His Thr Ile Ser Val Arg Val Lys Ala Ala Pro Tyr Trp Leu Asp 
            340                 345                 350         


Glu Pro Lys Asn Leu Ile Leu Ala Pro Gly Glu Asp Gly Arg Leu Val 
        355                 360                 365             


Cys Arg Ala Asn Gly Asn Pro Lys Pro Thr Val Gln Trp Met Val Asn 
    370                 375                 380                 


Gly Glu Pro Leu Gln Ser Ala Pro Pro Asn Pro Asn Arg Glu Val Ala 
385                 390                 395                 400 


Gly Asp Thr Ile Ile Phe Arg Asp Thr Gln Ile Ser Ser Arg Ala Val 
                405                 410                 415     


Tyr Gln Cys Asn Thr Ser Asn Glu His Gly Tyr Leu Leu Ala Asn Ala 
            420                 425                 430         


Phe Val Ser Val Leu Asp Val Pro Pro Arg Met Leu Ser Pro Arg Asn 
        435                 440                 445             


Gln Leu Ile Arg Val Ile Leu Tyr Asn Arg Thr Arg Leu Asp Cys Pro 
    450                 455                 460                 


Phe Phe Gly Ser Pro Ile Pro Thr Leu Arg Trp Phe Lys Asn Gly Gln 
465                 470                 475                 480 


Gly Ser Asn Leu Asp Gly Gly Asn Tyr His Val Tyr Glu Asn Gly Ser 
                485                 490                 495     


Leu Glu Ile Lys Met Ile Arg Lys Glu Asp Gln Gly Ile Tyr Thr Cys 
            500                 505                 510         


Val Ala Thr Asn Ile Leu Gly Lys Ala Glu Asn Gln Val Arg Leu Glu 
        515                 520                 525             


Val Lys Asp Pro Thr Arg Ile Tyr Arg Met Pro Glu Asp Gln Val Ala 
    530                 535                 540                 


Arg Arg Gly Thr Thr Val Gln Leu Glu Cys Arg Val Lys His Asp Pro 
545                 550                 555                 560 


Ser Leu Lys Leu Thr Val Ser Trp Leu Lys Asp Asp Glu Pro Leu Tyr 
                565                 570                 575     


Ile Gly Asn Arg Met Lys Lys Glu Asp Asp Ser Leu Thr Ile Phe Gly 
            580                 585                 590         


Val Ala Glu Arg Asp Gln Gly Ser Tyr Thr Cys Val Ala Ser Thr Glu 
        595                 600                 605             


Leu Asp Gln Asp Leu Ala Lys Ala Tyr Leu Thr Val Leu Gly Arg Pro 
    610                 615                 620                 


Asp Arg Pro Arg Asp Leu Glu Leu Thr Asp Leu Ala Glu Arg Ser Val 
625                 630                 635                 640 


Arg Leu Thr Trp Ile Pro Gly Asp Ala Asn Asn Ser Pro Ile Thr Asp 
                645                 650                 655     


Tyr Val Val Gln Phe Glu Glu Asp Gln Phe Gln Pro Gly Val Trp His 
            660                 665                 670         


Asp His Ser Lys Tyr Pro Gly Ser Val Asn Ser Ala Val Leu Arg Leu 
        675                 680                 685             


Ser Pro Tyr Val Asn Tyr Gln Phe Arg Val Ile Ala Ile Asn Glu Val 
    690                 695                 700                 


Gly Ser Ser His Pro Ser Leu Pro Ser Glu Arg Tyr Arg Thr Ser Gly 
705                 710                 715                 720 


Ala Pro Pro Glu Ser Asn Pro Gly Asp Val Lys Gly Glu Gly Thr Arg 
                725                 730                 735     


Lys Asn Asn Met Glu Ile Thr Trp Thr Pro Met Asn Ala Thr Ser Ala 
            740                 745                 750         


Phe Gly Pro Asn Leu Arg Tyr Ile Val Lys Trp Arg Arg Arg Glu Thr 
        755                 760                 765             


Arg Glu Ala Trp Asn Asn Val Thr Val Trp Gly Ser Arg Tyr Val Val 
    770                 775                 780                 


Gly Gln Thr Pro Val Tyr Val Pro Tyr Glu Ile Arg Val Gln Ala Glu 
785                 790                 795                 800 


Asn Asp Phe Gly Lys Gly Pro Glu Pro Glu Ser Val Ile Gly Tyr Ser 
                805                 810                 815     


Gly Glu Asp Tyr Pro Arg Ala Ala Pro Thr Glu Val Lys Val Arg Val 
            820                 825                 830         


Met Asn Ser Thr Ala Ile Ser Leu Gln Trp Asn Arg Val Tyr Ser Asp 
        835                 840                 845             


Thr Val Gln Gly Gln Leu Arg Glu Tyr Arg Ala Tyr Tyr Trp Arg Glu 
    850                 855                 860                 


Ser Ser Leu Leu Lys Asn Leu Trp Val Ser Gln Lys Arg Gln Gln Ala 
865                 870                 875                 880 


Ser Phe Pro Gly Asp Arg Leu Arg Gly Val Val Ser Arg Leu Phe Pro 
                885                 890                 895     


Tyr Ser Asn Tyr Lys Leu Glu Met Val Val Val Asn Gly Arg Gly Asp 
            900                 905                 910         


Gly Pro Arg Ser Glu Thr Lys Glu Phe Thr Thr Pro Glu Gly Val Pro 
        915                 920                 925             


Ser Ala Pro Arg Arg Phe Arg Val Arg Gln Pro Asn Leu Glu Thr Ile 
    930                 935                 940                 


Asn Leu Glu Trp Asp His Pro Glu His Pro Asn Gly Ile Met Ile Gly 
945                 950                 955                 960 


Tyr Thr Leu Lys Tyr Val Ala Phe Asn Gly Thr Lys Val Gly Lys Gln 
                965                 970                 975     


Ile Val Glu Asn Phe Ser Pro Asn Gln Thr Lys Phe Thr Val Gln Arg 
            980                 985                 990         


Thr Asp Pro Val Ser Arg Tyr Arg  Phe Thr Leu Ser Ala  Arg Thr Gln 
        995                 1000                 1005             


Val Gly  Ser Gly Glu Ala Val  Thr Glu Glu Ser Pro  Ala Pro Pro 
    1010                 1015                 1020             


Asn Glu  Ala Tyr Thr Asn Asn  Gln Ala Asp Ile Ala  Thr Gln Gly 
    1025                 1030                 1035             


Trp Phe  Ile Gly Leu Met Cys  Ala Ile Ala Leu Leu  Val Leu Ile 
    1040                 1045                 1050             


Leu Leu  Ile Val Cys Phe Ile  Lys Arg Ser Arg Gly  Gly Lys Tyr 
    1055                 1060                 1065             


Pro Val  Arg Glu Lys Lys Asp  Val Pro Leu Gly Pro  Glu Asp Pro 
    1070                 1075                 1080             


Lys Glu  Glu Asp Gly Ser Phe  Asp Tyr Ser Asp Glu  Asp Asn Lys 
    1085                 1090                 1095             


Pro Leu  Gln Gly Ser Gln Thr  Ser Leu Asp Gly Thr  Ile Lys Gln 
    1100                 1105                 1110             


Gln Glu  Ser Asp Asp Ser Leu  Val Asp Tyr Gly Glu  Gly Gly Glu 
    1115                 1120                 1125             


Gly Gln  Phe Asn Glu Asp Gly  Ser Phe Ile Gly Gln  Tyr Thr Val 
    1130                 1135                 1140             


Lys Lys  Asp Lys Glu Glu Thr  Glu Gly Asn Glu Ser  Ser Glu Ala 
    1145                 1150                 1155             


Thr Ser  Pro Val Asn Ala Ile  Tyr Ser Leu Ala 
    1160                 1165                 


<210>  4032
<211>  1426
<212>  PRT
<213>  Homo sapiens

<400>  4032

Met Asn Asp Trp His Arg Ile Phe Thr Gln Asn Val Leu Val Pro Pro 
1               5                   10                  15      


His Pro Gln Arg Ala Arg Gln Pro Trp Lys Glu Ser Thr Ala Phe Gln 
            20                  25                  30          


Cys Val Leu Lys Trp Leu Asp Gly Pro Val Ile Arg Gln Gly Val Leu 
        35                  40                  45              


Glu Val Leu Ser Glu Val Glu Cys His Leu Arg Val Ser Phe Phe Asp 
    50                  55                  60                  


Val Thr Tyr Arg His Phe Phe Gly Arg Thr Trp Lys Thr Thr Val Lys 
65                  70                  75                  80  


Pro Thr Lys Arg Pro Pro Ser Arg Ile Val Phe Asn Glu Pro Leu Tyr 
                85                  90                  95      


Phe His Thr Ser Leu Asn His Pro His Ile Val Ala Val Val Glu Val 
            100                 105                 110         


Val Ala Glu Gly Lys Lys Arg Asp Gly Ser Leu Gln Thr Leu Ser Cys 
        115                 120                 125             


Gly Phe Gly Ile Leu Arg Ile Phe Ser Asn Gln Pro Asp Ser Pro Ile 
    130                 135                 140                 


Ser Ala Ser Gln Asp Lys Arg Leu Arg Leu Tyr His Gly Thr Pro Arg 
145                 150                 155                 160 


Ala Leu Leu His Pro Leu Leu Gln Asp Pro Ala Glu Gln Asn Arg His 
                165                 170                 175     


Met Thr Leu Ile Glu Asn Cys Ser Leu Gln Tyr Thr Leu Lys Pro His 
            180                 185                 190         


Pro Ala Leu Glu Pro Ala Phe His Leu Leu Pro Glu Asn Leu Leu Val 
        195                 200                 205             


Ser Gly Leu Gln Gln Ile Pro Gly Leu Leu Pro Ala His Gly Glu Ser 
    210                 215                 220                 


Gly Asp Ala Leu Arg Lys Pro Arg Leu Gln Lys Pro Ile Thr Gly His 
225                 230                 235                 240 


Leu Asp Asp Leu Phe Phe Thr Leu Tyr Pro Ser Leu Glu Lys Phe Glu 
                245                 250                 255     


Glu Glu Leu Leu Glu Leu His Val Gln Asp His Phe Gln Glu Gly Cys 
            260                 265                 270         


Gly Pro Leu Asp Gly Gly Ala Leu Glu Ile Leu Glu Arg Arg Leu Arg 
        275                 280                 285             


Val Gly Val His Asn Gly Leu Gly Phe Val Gln Arg Pro Gln Val Val 
    290                 295                 300                 


Val Leu Val Pro Glu Met Asp Val Ala Leu Thr Arg Ser Ala Ser Phe 
305                 310                 315                 320 


Ser Arg Lys Val Val Ser Ser Ser Lys Thr Ser Ser Gly Ser Gln Ala 
                325                 330                 335     


Leu Val Leu Arg Ser Arg Leu Arg Leu Pro Glu Met Val Gly His Pro 
            340                 345                 350         


Ala Phe Ala Val Ile Phe Gln Leu Glu Tyr Val Phe Ser Ser Pro Ala 
        355                 360                 365             


Gly Val Asp Gly Asn Ala Ala Ser Val Thr Ser Leu Ser Asn Leu Ala 
    370                 375                 380                 


Cys Met His Met Val Arg Trp Ala Val Trp Asn Pro Leu Leu Glu Ala 
385                 390                 395                 400 


Asp Ser Gly Arg Val Thr Leu Pro Leu Gln Gly Gly Ile Gln Pro Asn 
                405                 410                 415     


Pro Ser His Cys Leu Val Tyr Lys Val Pro Ser Ala Ser Met Ser Ser 
            420                 425                 430         


Glu Glu Val Lys Gln Val Glu Ser Gly Thr Leu Arg Phe Gln Phe Ser 
        435                 440                 445             


Leu Gly Ser Glu Glu His Leu Asp Ala Pro Thr Glu Pro Val Ser Gly 
    450                 455                 460                 


Pro Lys Val Glu Arg Arg Pro Ser Arg Lys Pro Pro Thr Ser Pro Ser 
465                 470                 475                 480 


Ser Pro Pro Ala Pro Val Pro Arg Val Leu Ala Ala Pro Gln Asn Ser 
                485                 490                 495     


Pro Val Gly Pro Gly Leu Ser Ile Ser Gln Leu Ala Ala Ser Pro Arg 
            500                 505                 510         


Ser Pro Thr Gln His Cys Leu Ala Arg Pro Thr Ser Gln Leu Pro His 
        515                 520                 525             


Gly Ser Gln Ala Ser Pro Ala Gln Ala Gln Glu Phe Pro Leu Glu Ala 
    530                 535                 540                 


Gly Ile Ser His Leu Glu Ala Asp Leu Ser Gln Thr Ser Leu Val Leu 
545                 550                 555                 560 


Glu Thr Ser Ile Ala Glu Gln Leu Gln Glu Leu Pro Phe Thr Pro Leu 
                565                 570                 575     


His Ala Pro Ile Val Val Gly Thr Gln Thr Arg Ser Ser Ala Gly Gln 
            580                 585                 590         


Pro Ser Arg Ala Ser Met Val Leu Leu Gln Ser Ser Gly Phe Pro Glu 
        595                 600                 605             


Ile Leu Asp Ala Asn Lys Gln Pro Ala Glu Ala Val Ser Ala Thr Glu 
    610                 615                 620                 


Pro Val Thr Phe Asn Pro Gln Lys Glu Glu Ser Asp Cys Leu Gln Ser 
625                 630                 635                 640 


Asn Glu Met Val Leu Gln Phe Leu Ala Phe Ser Arg Val Ala Gln Asp 
                645                 650                 655     


Cys Arg Gly Thr Ser Trp Pro Lys Thr Val Tyr Phe Thr Phe Gln Phe 
            660                 665                 670         


Tyr Arg Phe Pro Pro Ala Thr Thr Pro Arg Leu Gln Leu Val Gln Leu 
        675                 680                 685             


Asp Glu Ala Gly Gln Pro Ser Ser Gly Ala Leu Thr His Ile Leu Val 
    690                 695                 700                 


Pro Val Ser Arg Asp Gly Thr Phe Asp Ala Gly Ser Pro Gly Phe Gln 
705                 710                 715                 720 


Leu Arg Tyr Met Val Gly Pro Gly Phe Leu Lys Pro Gly Glu Arg Arg 
                725                 730                 735     


Cys Phe Ala Arg Tyr Leu Ala Val Gln Thr Leu Gln Ile Asp Val Trp 
            740                 745                 750         


Asp Gly Asp Ser Leu Leu Leu Ile Gly Ser Ala Ala Val Gln Met Lys 
        755                 760                 765             


His Leu Leu Arg Gln Gly Arg Pro Ala Val Gln Ala Ser His Glu Leu 
    770                 775                 780                 


Glu Val Val Ala Thr Glu Tyr Glu Gln Asp Asn Met Val Val Ser Gly 
785                 790                 795                 800 


Asp Met Leu Gly Phe Gly Arg Val Lys Pro Ile Gly Val His Ser Val 
                805                 810                 815     


Val Lys Gly Arg Leu His Leu Thr Leu Ala Asn Val Gly His Pro Cys 
            820                 825                 830         


Glu Gln Lys Val Arg Gly Cys Ser Thr Leu Pro Pro Ser Arg Ser Arg 
        835                 840                 845             


Val Ile Ser Asn Asp Gly Ala Ser Arg Phe Ser Gly Gly Ser Leu Leu 
    850                 855                 860                 


Thr Thr Gly Ser Ser Arg Arg Lys His Val Val Gln Ala Gln Lys Leu 
865                 870                 875                 880 


Ala Asp Val Asp Ser Glu Leu Ala Ala Met Leu Leu Thr His Ala Arg 
                885                 890                 895     


Gln Gly Lys Gly Pro Gln Asp Val Ser Arg Glu Ser Asp Ala Thr Arg 
            900                 905                 910         


Arg Arg Lys Leu Glu Arg Met Arg Ser Val Arg Leu Gln Glu Ala Gly 
        915                 920                 925             


Gly Asp Leu Gly Arg Arg Gly Thr Ser Val Leu Ala Gln Gln Ser Val 
    930                 935                 940                 


Arg Thr Gln His Leu Arg Asp Leu Gln Val Ile Ala Ala Tyr Arg Glu 
945                 950                 955                 960 


Arg Thr Lys Ala Glu Ser Ile Ala Ser Leu Leu Ser Leu Ala Ile Thr 
                965                 970                 975     


Thr Glu His Thr Leu His Ala Thr Leu Gly Val Ala Glu Phe Phe Glu 
            980                 985                 990         


Phe Val Leu Lys Asn Pro His Asn  Thr Gln His Thr Val  Thr Val Glu 
        995                 1000                 1005             


Ile Asp  Asn Pro Glu Leu Ser  Val Ile Val Asp Ser  Gln Glu Trp 
    1010                 1015                 1020             


Arg Asp  Phe Lys Gly Ala Ala  Gly Leu His Thr Pro  Val Glu Glu 
    1025                 1030                 1035             


Asp Met  Phe His Leu Arg Gly  Ser Leu Ala Pro Gln  Leu Tyr Leu 
    1040                 1045                 1050             


Arg Pro  His Glu Thr Ala His  Val Pro Phe Lys Phe  Gln Ser Phe 
    1055                 1060                 1065             


Ser Ala  Gly Gln Leu Ala Met  Val Gln Ala Ser Pro  Gly Leu Ser 
    1070                 1075                 1080             


Asn Glu  Lys Gly Met Asp Ala  Val Ser Pro Trp Lys  Ser Ser Ala 
    1085                 1090                 1095             


Val Pro  Thr Lys His Ala Lys  Val Leu Phe Arg Ala  Ser Gly Gly 
    1100                 1105                 1110             


Lys Pro  Ile Ala Val Leu Cys  Leu Thr Val Glu Leu  Gln Pro His 
    1115                 1120                 1125             


Val Val  Asp Gln Val Phe Arg  Phe Tyr His Pro Glu  Leu Ser Phe 
    1130                 1135                 1140             


Leu Lys  Lys Ala Ile Arg Leu  Pro Pro Trp His Thr  Phe Pro Gly 
    1145                 1150                 1155             


Ala Pro  Val Gly Met Leu Gly  Glu Asp Pro Pro Val  His Val Arg 
    1160                 1165                 1170             


Cys Ser  Asp Pro Asn Val Ile  Cys Glu Thr Gln Asn  Val Gly Pro 
    1175                 1180                 1185             


Gly Glu  Pro Arg Asp Ile Phe  Leu Lys Val Ala Ser  Gly Pro Ser 
    1190                 1195                 1200             


Pro Glu  Ile Lys Asp Phe Phe  Val Ile Ile Tyr Ser  Asp Arg Trp 
    1205                 1210                 1215             


Leu Ala  Thr Pro Thr Gln Thr  Trp Gln Val Tyr Leu  His Ser Leu 
    1220                 1225                 1230             


Gln Arg  Val Asp Val Ser Cys  Val Ala Gly Gln Leu  Thr Arg Leu 
    1235                 1240                 1245             


Ser Leu  Val Leu Arg Gly Thr  Gln Thr Val Arg Lys  Val Arg Ala 
    1250                 1255                 1260             


Phe Thr  Ser His Pro Gln Glu  Leu Lys Thr Asp Pro  Lys Gly Val 
    1265                 1270                 1275             


Phe Val  Leu Pro Pro Arg Gly  Val Gln Asp Leu His  Val Gly Val 
    1280                 1285                 1290             


Arg Pro  Leu Arg Ala Gly Ser  Arg Phe Val His Leu  Asn Leu Val 
    1295                 1300                 1305             


Asp Val  Asp Cys His Gln Leu  Val Ala Ser Trp Leu  Val Cys Leu 
    1310                 1315                 1320             


Cys Cys  Arg Gln Pro Leu Ile  Ser Lys Ala Phe Glu  Ile Met Leu 
    1325                 1330                 1335             


Ala Ala  Gly Glu Gly Lys Gly  Val Asn Lys Arg Ile  Thr Tyr Thr 
    1340                 1345                 1350             


Asn Pro  Tyr Pro Ser Arg Arg  Thr Phe His Leu His  Ser Asp His 
    1355                 1360                 1365             


Pro Glu  Leu Leu Arg Phe Arg  Glu Asp Ser Phe Gln  Val Gly Gly 
    1370                 1375                 1380             


Gly Glu  Thr Tyr Thr Ile Gly  Leu Gln Phe Ala Pro  Ser Gln Arg 
    1385                 1390                 1395             


Val Gly  Glu Glu Glu Ile Leu  Ile Tyr Ile Asn Asp  His Glu Asp 
    1400                 1405                 1410             


Lys Asn  Glu Glu Ala Phe Cys  Val Lys Val Ile Tyr  Gln 
    1415                 1420                 1425     


<210>  4033
<211>  1925
<212>  PRT
<213>  Homo sapiens

<400>  4033

Met Ala Pro Arg Ala Ala Gly Gly Ala Pro Leu Ser Ala Arg Ala Ala 
1               5                   10                  15      


Ala Ala Ser Pro Pro Pro Phe Gln Thr Pro Pro Arg Cys Pro Val Pro 
            20                  25                  30          


Leu Leu Leu Leu Leu Leu Leu Gly Ala Ala Arg Ala Gly Ala Leu Glu 
        35                  40                  45              


Ile Gln Arg Arg Phe Pro Ser Pro Thr Pro Thr Asn Asn Phe Ala Leu 
    50                  55                  60                  


Asp Gly Ala Ala Gly Thr Val Tyr Leu Ala Ala Val Asn Arg Leu Tyr 
65                  70                  75                  80  


Gln Leu Ser Gly Ala Asn Leu Ser Leu Glu Ala Glu Ala Ala Val Gly 
                85                  90                  95      


Pro Val Pro Asp Ser Pro Leu Cys His Ala Pro Gln Leu Pro Gln Ala 
            100                 105                 110         


Ser Cys Glu His Pro Arg Arg Leu Thr Asp Asn Tyr Asn Lys Ile Leu 
        115                 120                 125             


Gln Leu Asp Pro Gly Gln Gly Leu Val Val Val Cys Gly Ser Ile Tyr 
    130                 135                 140                 


Gln Gly Phe Cys Gln Leu Arg Arg Arg Gly Asn Ile Ser Ala Val Ala 
145                 150                 155                 160 


Val Arg Phe Pro Pro Ala Ala Pro Pro Ala Glu Pro Val Thr Val Phe 
                165                 170                 175     


Pro Ser Met Leu Asn Val Ala Ala Asn His Pro Asn Ala Ser Thr Val 
            180                 185                 190         


Gly Leu Val Leu Pro Pro Ala Ala Gly Ala Gly Gly Ser Arg Leu Leu 
        195                 200                 205             


Val Gly Ala Thr Tyr Thr Gly Tyr Gly Ser Ser Phe Phe Pro Arg Asn 
    210                 215                 220                 


Arg Ser Leu Glu Asp His Arg Phe Glu Asn Thr Pro Glu Ile Ala Ile 
225                 230                 235                 240 


Arg Ser Leu Asp Thr Arg Gly Asp Leu Ala Lys Leu Phe Thr Phe Asp 
                245                 250                 255     


Leu Asn Pro Ser Asp Asp Asn Ile Leu Lys Ile Lys Gln Gly Ala Lys 
            260                 265                 270         


Glu Gln His Lys Leu Gly Phe Val Ser Ala Phe Leu His Pro Ser Asp 
        275                 280                 285             


Pro Pro Pro Gly Ala Gln Ser Tyr Ala Tyr Leu Ala Leu Asn Ser Glu 
    290                 295                 300                 


Ala Arg Ala Gly Asp Lys Glu Ser Gln Ala Arg Ser Leu Leu Ala Arg 
305                 310                 315                 320 


Ile Cys Leu Pro His Gly Ala Gly Gly Asp Ala Lys Lys Leu Thr Glu 
                325                 330                 335     


Ser Tyr Ile Gln Leu Gly Leu Gln Cys Ala Gly Gly Ala Gly Arg Gly 
            340                 345                 350         


Asp Leu Tyr Ser Arg Leu Val Ser Val Phe Pro Ala Arg Glu Arg Leu 
        355                 360                 365             


Phe Ala Val Phe Glu Arg Pro Gln Gly Ser Pro Ala Ala Arg Ala Ala 
    370                 375                 380                 


Pro Ala Ala Leu Cys Ala Phe Arg Phe Ala Asp Val Arg Ala Ala Ile 
385                 390                 395                 400 


Arg Ala Ala Arg Thr Ala Cys Phe Val Glu Pro Ala Pro Asp Val Val 
                405                 410                 415     


Ala Val Leu Asp Ser Val Val Gln Gly Thr Gly Pro Ala Cys Glu Arg 
            420                 425                 430         


Lys Leu Asn Ile Gln Leu Gln Pro Glu Gln Leu Asp Cys Gly Ala Ala 
        435                 440                 445             


His Leu Gln His Pro Leu Ser Ile Leu Gln Pro Leu Lys Ala Thr Pro 
    450                 455                 460                 


Val Phe Arg Ala Pro Gly Leu Thr Ser Val Ala Val Ala Ser Val Asn 
465                 470                 475                 480 


Asn Tyr Thr Ala Val Phe Leu Gly Thr Val Asn Gly Arg Leu Leu Lys 
                485                 490                 495     


Ile Asn Leu Asn Glu Ser Met Gln Val Val Ser Arg Arg Val Val Thr 
            500                 505                 510         


Val Ala Tyr Gly Glu Pro Val His His Val Met Gln Phe Asp Pro Ala 
        515                 520                 525             


Asp Ser Gly Tyr Leu Tyr Leu Met Thr Ser His Gln Met Ala Arg Val 
    530                 535                 540                 


Lys Val Ala Ala Cys Asn Val His Ser Thr Cys Gly Asp Cys Val Gly 
545                 550                 555                 560 


Ala Ala Asp Ala Tyr Cys Gly Trp Cys Ala Leu Glu Thr Arg Cys Thr 
                565                 570                 575     


Leu Gln Gln Asp Cys Thr Asn Ser Ser Gln Gln His Phe Trp Thr Ser 
            580                 585                 590         


Ala Ser Glu Gly Pro Ser Arg Cys Pro Ala Met Thr Val Leu Pro Ser 
        595                 600                 605             


Glu Ile Asp Val Arg Gln Glu Tyr Pro Gly Met Ile Leu Gln Ile Ser 
    610                 615                 620                 


Gly Ser Leu Pro Ser Leu Ser Gly Met Glu Met Ala Cys Asp Tyr Gly 
625                 630                 635                 640 


Asn Asn Ile Arg Thr Val Ala Arg Val Pro Gly Pro Ala Phe Gly His 
                645                 650                 655     


Gln Ile Ala Tyr Cys Asn Leu Leu Pro Arg Asp Gln Phe Pro Pro Phe 
            660                 665                 670         


Pro Pro Asn Gln Asp His Val Thr Val Glu Met Ser Val Arg Val Asn 
        675                 680                 685             


Gly Arg Asn Ile Val Lys Ala Asn Phe Thr Ile Tyr Asp Cys Ser Arg 
    690                 695                 700                 


Thr Ala Gln Val Tyr Pro His Thr Ala Cys Thr Ser Cys Leu Ser Ala 
705                 710                 715                 720 


Gln Trp Pro Cys Phe Trp Cys Ser Gln Gln His Ser Cys Val Ser Asn 
                725                 730                 735     


Gln Ser Arg Cys Glu Ala Ser Pro Asn Pro Thr Ser Pro Gln Asp Cys 
            740                 745                 750         


Pro Arg Thr Leu Leu Ser Pro Leu Ala Pro Val Pro Thr Gly Gly Ser 
        755                 760                 765             


Gln Asn Ile Leu Val Pro Leu Ala Asn Thr Ala Phe Phe Gln Gly Ala 
    770                 775                 780                 


Ala Leu Glu Cys Ser Phe Gly Leu Glu Glu Ile Phe Glu Ala Val Trp 
785                 790                 795                 800 


Val Asn Glu Ser Val Val Arg Cys Asp Gln Val Val Leu His Thr Thr 
                805                 810                 815     


Arg Lys Ser Gln Val Phe Pro Leu Ser Leu Gln Leu Lys Gly Arg Pro 
            820                 825                 830         


Ala Arg Phe Leu Asp Ser Pro Glu Pro Met Thr Val Met Val Tyr Asn 
        835                 840                 845             


Cys Ala Met Gly Ser Pro Asp Cys Ser Gln Cys Leu Gly Arg Glu Asp 
    850                 855                 860                 


Leu Gly His Leu Cys Met Trp Ser Asp Gly Cys Arg Leu Arg Gly Pro 
865                 870                 875                 880 


Leu Gln Pro Met Ala Gly Thr Cys Pro Ala Pro Glu Ile Arg Ala Ile 
                885                 890                 895     


Glu Pro Leu Ser Gly Pro Leu Asp Gly Gly Thr Leu Leu Thr Ile Arg 
            900                 905                 910         


Gly Arg Asn Leu Gly Arg Arg Leu Ser Asp Val Ala His Gly Val Trp 
        915                 920                 925             


Ile Gly Gly Val Ala Cys Glu Pro Leu Pro Asp Arg Tyr Thr Val Ser 
    930                 935                 940                 


Glu Glu Ile Val Cys Val Thr Gly Pro Ala Pro Gly Pro Leu Ser Gly 
945                 950                 955                 960 


Val Val Thr Val Asn Ala Ser Lys Glu Gly Lys Ser Arg Asp Arg Phe 
                965                 970                 975     


Ser Tyr Val Leu Pro Leu Val His Ser Leu Glu Pro Thr Met Gly Pro 
            980                 985                 990         


Lys Ala Gly Gly Thr Arg Ile Thr  Ile His Gly Asn Asp  Leu His Val 
        995                 1000                 1005             


Gly Ser  Glu Leu Gln Val Leu  Val Asn Asp Thr Asp  Pro Cys Thr 
    1010                 1015                 1020             


Glu Leu  Met Arg Thr Asp Thr  Ser Ile Ala Cys Thr  Met Pro Glu 
    1025                 1030                 1035             


Gly Ala  Leu Pro Ala Pro Val  Pro Val Cys Val Arg  Phe Glu Arg 
    1040                 1045                 1050             


Arg Gly  Cys Val His Gly Asn  Leu Thr Phe Trp Tyr  Met Gln Asn 
    1055                 1060                 1065             


Pro Val  Ile Thr Ala Ile Ser  Pro Arg Arg Ser Pro  Val Ser Gly 
    1070                 1075                 1080             


Gly Arg  Thr Ile Thr Val Ala  Gly Glu Arg Phe His  Met Val Gln 
    1085                 1090                 1095             


Asn Val  Ser Met Ala Val His  His Ile Gly Arg Glu  Pro Thr Leu 
    1100                 1105                 1110             


Cys Lys  Val Leu Asn Ser Thr  Leu Ile Thr Cys Pro  Ser Pro Gly 
    1115                 1120                 1125             


Ala Leu  Ser Asn Ala Ser Ala  Pro Val Asp Phe Phe  Ile Asn Gly 
    1130                 1135                 1140             


Arg Ala  Tyr Ala Asp Glu Val  Ala Val Ala Glu Glu  Leu Leu Asp 
    1145                 1150                 1155             


Pro Glu  Glu Ala Gln Arg Gly  Ser Arg Phe Arg Leu  Asp Tyr Leu 
    1160                 1165                 1170             


Pro Asn  Pro Gln Phe Ser Thr  Ala Lys Arg Glu Lys  Trp Ile Lys 
    1175                 1180                 1185             


His His  Pro Gly Glu Pro Leu  Thr Leu Val Ile His  Lys Glu Gln 
    1190                 1195                 1200             


Asp Ser  Leu Gly Leu Gln Ser  His Glu Tyr Arg Val  Lys Ile Gly 
    1205                 1210                 1215             


Gln Val  Ser Cys Asp Ile Gln  Ile Val Ser Asp Arg  Ile Ile His 
    1220                 1225                 1230             


Cys Ser  Val Asn Glu Ser Leu  Gly Ala Ala Val Gly  Gln Leu Pro 
    1235                 1240                 1245             


Ile Thr  Ile Gln Val Gly Asn  Phe Asn Gln Thr Ile  Ala Thr Leu 
    1250                 1255                 1260             


Gln Leu  Gly Gly Ser Glu Thr  Ala Ile Ile Val Ser  Ile Val Ile 
    1265                 1270                 1275             


Cys Ser  Val Leu Leu Leu Leu  Ser Val Val Ala Leu  Phe Val Phe 
    1280                 1285                 1290             


Cys Thr  Lys Ser Arg Arg Ala  Glu Arg Tyr Trp Gln  Lys Thr Leu 
    1295                 1300                 1305             


Leu Gln  Met Glu Glu Met Glu  Ser Gln Ile Arg Glu  Glu Ile Arg 
    1310                 1315                 1320             


Lys Gly  Phe Ala Glu Leu Gln  Thr Asp Met Thr Asp  Leu Thr Lys 
    1325                 1330                 1335             


Glu Leu  Asn Arg Ser Gln Gly  Ile Pro Phe Leu Glu  Tyr Lys His 
    1340                 1345                 1350             


Phe Val  Thr Arg Thr Phe Phe  Pro Lys Cys Ser Ser  Leu Tyr Glu 
    1355                 1360                 1365             


Glu Arg  Tyr Val Leu Pro Ser  Gln Thr Leu Asn Ser  Gln Gly Ser 
    1370                 1375                 1380             


Ser Gln  Ala Gln Glu Thr His  Pro Leu Leu Gly Glu  Trp Lys Ile 
    1385                 1390                 1395             


Pro Glu  Ser Cys Arg Pro Asn  Met Glu Glu Gly Ile  Ser Leu Phe 
    1400                 1405                 1410             


Ser Ser  Leu Leu Asn Asn Lys  His Phe Leu Ile Val  Phe Val His 
    1415                 1420                 1425             


Ala Leu  Glu Gln Gln Lys Asp  Phe Ala Val Arg Asp  Arg Cys Ser 
    1430                 1435                 1440             


Leu Ala  Ser Leu Leu Thr Ile  Ala Leu His Gly Lys  Leu Glu Tyr 
    1445                 1450                 1455             


Tyr Thr  Ser Ile Met Lys Glu  Leu Leu Val Asp Leu  Ile Asp Ala 
    1460                 1465                 1470             


Ser Ala  Ala Lys Asn Pro Lys  Leu Met Leu Arg Arg  Thr Glu Ser 
    1475                 1480                 1485             


Val Val  Glu Lys Met Leu Thr  Asn Trp Met Ser Ile  Cys Met Tyr 
    1490                 1495                 1500             


Ser Cys  Leu Arg Glu Thr Val  Gly Glu Pro Phe Phe  Leu Leu Leu 
    1505                 1510                 1515             


Cys Ala  Ile Lys Gln Gln Ile  Asn Lys Gly Ser Ile  Asp Ala Ile 
    1520                 1525                 1530             


Thr Gly  Lys Ala Arg Tyr Thr  Leu Asn Glu Glu Trp  Leu Leu Arg 
    1535                 1540                 1545             


Glu Asn  Ile Glu Ala Lys Pro  Arg Asn Leu Asn Val  Ser Phe Gln 
    1550                 1555                 1560             


Gly Cys  Gly Met Asp Ser Leu  Ser Val Arg Ala Met  Asp Thr Asp 
    1565                 1570                 1575             


Thr Leu  Thr Gln Val Lys Glu  Lys Ile Leu Glu Ala  Phe Cys Lys 
    1580                 1585                 1590             


Asn Val  Pro Tyr Ser Gln Trp  Pro Arg Ala Glu Asp  Val Asp Leu 
    1595                 1600                 1605             


Glu Trp  Phe Ala Ser Ser Thr  Gln Ser Tyr Ile Leu  Arg Asp Leu 
    1610                 1615                 1620             


Asp Asp  Thr Ser Val Val Glu  Asp Gly Arg Lys Lys  Leu Asn Thr 
    1625                 1630                 1635             


Leu Ala  His Tyr Lys Ile Pro  Glu Gly Ala Ser Leu  Ala Met Ser 
    1640                 1645                 1650             


Leu Ile  Asp Lys Lys Asp Asn  Thr Leu Gly Arg Val  Lys Asp Leu 
    1655                 1660                 1665             


Asp Thr  Glu Lys Tyr Phe His  Leu Val Leu Pro Thr  Asp Glu Leu 
    1670                 1675                 1680             


Ala Glu  Pro Lys Lys Ser His  Arg Gln Ser His Arg  Lys Lys Val 
    1685                 1690                 1695             


Leu Pro  Glu Ile Tyr Leu Thr  Arg Leu Leu Ser Thr  Lys Gly Thr 
    1700                 1705                 1710             


Leu Gln  Lys Phe Leu Asp Asp  Leu Phe Lys Ala Ile  Leu Ser Ile 
    1715                 1720                 1725             


Arg Glu  Asp Lys Pro Pro Leu  Ala Val Lys Tyr Phe  Phe Asp Phe 
    1730                 1735                 1740             


Leu Glu  Glu Gln Ala Glu Lys  Arg Gly Ile Ser Asp  Pro Asp Thr 
    1745                 1750                 1755             


Leu His  Ile Trp Lys Thr Asn  Ser Leu Pro Leu Arg  Phe Trp Val 
    1760                 1765                 1770             


Asn Ile  Leu Lys Asn Pro Gln  Phe Val Phe Asp Ile  Asp Lys Thr 
    1775                 1780                 1785             


Asp His  Ile Asp Ala Cys Leu  Ser Val Ile Ala Gln  Ala Phe Ile 
    1790                 1795                 1800             


Asp Ala  Cys Ser Ile Ser Asp  Leu Gln Leu Gly Lys  Asp Ser Pro 
    1805                 1810                 1815             


Thr Asn  Lys Leu Leu Tyr Ala  Lys Glu Ile Pro Glu  Tyr Arg Lys 
    1820                 1825                 1830             


Ile Val  Gln Arg Tyr Tyr Lys  Gln Ile Gln Asp Met  Thr Pro Leu 
    1835                 1840                 1845             


Ser Glu  Gln Glu Met Asn Ala  His Leu Ala Glu Glu  Ser Arg Lys 
    1850                 1855                 1860             


Tyr Gln  Asn Glu Phe Asn Thr  Asn Val Ala Met Ala  Glu Ile Tyr 
    1865                 1870                 1875             


Lys Tyr  Ala Lys Arg Tyr Arg  Pro Gln Ile Met Ala  Ala Leu Glu 
    1880                 1885                 1890             


Ala Asn  Pro Thr Ala Arg Arg  Thr Gln Leu Gln His  Lys Phe Glu 
    1895                 1900                 1905             


Gln Val  Val Ala Leu Met Glu  Asp Asn Ile Tyr Glu  Cys Tyr Ser 
    1910                 1915                 1920             


Glu Ala  
    1925 


<210>  4034
<211>  938
<212>  PRT
<213>  Homo sapiens

<400>  4034

Met Leu Trp Pro Arg Leu Ala Ala Ala Glu Trp Ala Ala Leu Ala Trp 
1               5                   10                  15      


Glu Leu Leu Gly Ala Ser Val Leu Leu Ile Ala Val Arg Trp Leu Val 
            20                  25                  30          


Arg Arg Leu Gly Pro Arg Pro Gly Gly Leu Gly Arg Ser Gly Thr Pro 
        35                  40                  45              


Val Pro Pro Pro Ser Ala Ala Ala Ala Pro Ala Ser Gly Glu Met Thr 
    50                  55                  60                  


Met Asp Ala Leu Leu Ala Arg Leu Lys Leu Leu Asn Pro Asp Asp Leu 
65                  70                  75                  80  


Arg Glu Glu Ile Val Lys Ala Gly Leu Lys Cys Gly Pro Ile Thr Ser 
                85                  90                  95      


Thr Thr Arg Phe Ile Phe Glu Lys Lys Leu Ala Gln Ala Leu Leu Glu 
            100                 105                 110         


Gln Gly Gly Arg Leu Ser Ser Phe Tyr His His Glu Ala Gly Val Thr 
        115                 120                 125             


Ala Leu Ser Gln Asp Pro Gln Arg Ile Leu Lys Pro Ala Glu Gly Asn 
    130                 135                 140                 


Pro Thr Asp Gln Ala Gly Phe Ser Glu Asp Arg Asp Phe Gly Tyr Ser 
145                 150                 155                 160 


Val Gly Leu Asn Pro Pro Glu Glu Glu Ala Val Thr Ser Lys Thr Cys 
                165                 170                 175     


Ser Val Pro Pro Ser Asp Thr Asp Thr Tyr Arg Ala Gly Ala Thr Ala 
            180                 185                 190         


Ser Lys Glu Pro Pro Leu Tyr Tyr Gly Val Cys Pro Val Tyr Glu Asp 
        195                 200                 205             


Val Pro Ala Arg Asn Glu Arg Ile Tyr Val Tyr Glu Asn Lys Lys Glu 
    210                 215                 220                 


Ala Leu Gln Ala Val Lys Met Ile Lys Gly Ser Arg Phe Lys Ala Phe 
225                 230                 235                 240 


Ser Thr Arg Glu Asp Ala Glu Lys Phe Ala Arg Gly Ile Cys Asp Tyr 
                245                 250                 255     


Phe Pro Ser Pro Ser Lys Thr Ser Leu Pro Leu Ser Pro Val Lys Thr 
            260                 265                 270         


Ala Pro Leu Phe Ser Asn Asp Arg Leu Lys Asp Gly Leu Cys Leu Ser 
        275                 280                 285             


Glu Ser Glu Thr Val Asn Lys Glu Arg Ala Asn Ser Tyr Lys Asn Pro 
    290                 295                 300                 


Arg Thr Gln Asp Leu Thr Ala Lys Leu Arg Lys Ala Val Glu Lys Gly 
305                 310                 315                 320 


Glu Glu Asp Thr Phe Ser Asp Leu Ile Trp Ser Asn Pro Arg Tyr Leu 
                325                 330                 335     


Ile Gly Ser Gly Asp Asn Pro Thr Ile Val Gln Glu Gly Cys Arg Tyr 
            340                 345                 350         


Asn Val Met His Val Ala Ala Lys Glu Asn Gln Ala Ser Ile Cys Gln 
        355                 360                 365             


Leu Thr Leu Asp Val Leu Glu Asn Pro Asp Phe Met Arg Leu Met Tyr 
    370                 375                 380                 


Pro Asp Asp Asp Glu Ala Met Leu Gln Lys Arg Ile Arg Tyr Val Val 
385                 390                 395                 400 


Asp Leu Tyr Leu Asn Thr Pro Asp Lys Met Gly Tyr Asp Thr Pro Leu 
                405                 410                 415     


His Phe Ala Cys Lys Phe Gly Asn Ala Asp Val Val Asn Val Leu Ser 
            420                 425                 430         


Ser His His Leu Ile Val Lys Asn Ser Arg Asn Lys Tyr Asp Lys Thr 
        435                 440                 445             


Pro Glu Asp Val Ile Cys Glu Arg Ser Lys Asn Lys Ser Val Glu Leu 
    450                 455                 460                 


Lys Glu Arg Ile Arg Glu Tyr Leu Lys Gly His Tyr Tyr Val Pro Leu 
465                 470                 475                 480 


Leu Arg Ala Glu Glu Thr Ser Ser Pro Val Ile Gly Glu Leu Trp Ser 
                485                 490                 495     


Pro Asp Gln Thr Ala Glu Ala Ser His Val Ser Arg Tyr Gly Gly Ser 
            500                 505                 510         


Pro Arg Asp Pro Val Leu Thr Leu Arg Ala Phe Ala Gly Pro Leu Ser 
        515                 520                 525             


Pro Ala Lys Ala Glu Asp Phe Arg Lys Leu Trp Lys Thr Pro Pro Arg 
    530                 535                 540                 


Glu Lys Ala Gly Phe Leu His His Val Lys Lys Ser Asp Pro Glu Arg 
545                 550                 555                 560 


Gly Phe Glu Arg Val Gly Arg Glu Leu Ala His Glu Leu Gly Tyr Pro 
                565                 570                 575     


Trp Val Glu Tyr Trp Glu Phe Leu Gly Cys Phe Val Asp Leu Ser Ser 
            580                 585                 590         


Gln Glu Gly Leu Gln Arg Leu Glu Glu Tyr Leu Thr Gln Gln Glu Ile 
        595                 600                 605             


Gly Lys Lys Ala Gln Gln Glu Thr Gly Glu Arg Glu Ala Ser Cys Arg 
    610                 615                 620                 


Asp Lys Ala Thr Thr Ser Gly Ser Asn Ser Ile Ser Val Arg Ala Phe 
625                 630                 635                 640 


Leu Asp Glu Asp Asp Met Ser Leu Glu Glu Ile Lys Asn Arg Gln Asn 
                645                 650                 655     


Ala Ala Arg Asn Asn Ser Pro Pro Thr Val Gly Ala Phe Gly His Thr 
            660                 665                 670         


Arg Cys Ser Ala Phe Pro Leu Glu Gln Glu Ala Asp Leu Ile Glu Ala 
        675                 680                 685             


Ala Glu Pro Gly Gly Pro His Ser Ser Arg Asn Gly Leu Cys His Pro 
    690                 695                 700                 


Leu Asn His Ser Arg Thr Leu Ala Gly Lys Arg Pro Lys Ala Pro Arg 
705                 710                 715                 720 


Gly Glu Glu Ala His Leu Pro Pro Val Ser Asp Leu Thr Val Glu Phe 
                725                 730                 735     


Asp Lys Leu Asn Leu Gln Asn Ile Gly Arg Ser Val Ser Lys Thr Pro 
            740                 745                 750         


Asp Glu Ser Thr Lys Thr Lys Asp Gln Ile Leu Thr Ser Arg Ile Asn 
        755                 760                 765             


Ala Val Glu Arg Asp Leu Leu Glu Pro Ser Pro Ala Asp Gln Leu Gly 
    770                 775                 780                 


Asn Gly His Arg Arg Thr Glu Ser Glu Met Ser Ala Arg Ile Ala Lys 
785                 790                 795                 800 


Met Ser Leu Ser Pro Ser Ser Pro Arg His Glu Asp Gln Leu Glu Val 
                805                 810                 815     


Thr Arg Glu Pro Ala Arg Arg Leu Phe Leu Phe Gly Glu Glu Pro Ser 
            820                 825                 830         


Lys Leu Asp Gln Asp Val Leu Ala Ala Leu Glu Cys Ala Asp Val Asp 
        835                 840                 845             


Pro His Gln Phe Pro Ala Val His Arg Trp Lys Ser Ala Val Leu Cys 
    850                 855                 860                 


Tyr Ser Pro Ser Asp Arg Gln Ser Trp Pro Ser Pro Ala Val Lys Gly 
865                 870                 875                 880 


Arg Phe Lys Ser Gln Leu Pro Asp Leu Ser Gly Pro His Ser Tyr Ser 
                885                 890                 895     


Pro Gly Arg Asn Ser Val Ala Gly Ser Asn Pro Ala Lys Pro Gly Leu 
            900                 905                 910         


Gly Ser Pro Gly Arg Tyr Ser Pro Val His Gly Ser Gln Leu Arg Arg 
        915                 920                 925             


Met Ala Arg Leu Ala Glu Leu Ala Ala Leu 
    930                 935             


<210>  4035
<211>  728
<212>  PRT
<213>  Homo sapiens

<400>  4035

Met Ala Thr Pro Gly Ser Glu Pro Gln Pro Phe Val Pro Ala Leu Ser 
1               5                   10                  15      


Val Ala Thr Leu His Pro Leu His His Pro His His His His His His 
            20                  25                  30          


His Gln His His Gly Gly Thr Gly Ala Pro Gly Gly Ala Gly Gly Gly 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Phe Asn Leu Pro Leu Asn Arg Gly Leu Glu 
    50                  55                  60                  


Arg Ala Leu Glu Glu Ala Ala Asn Ser Gly Gly Leu Asn Leu Ser Ala 
65                  70                  75                  80  


Arg Lys Leu Lys Glu Phe Pro Arg Thr Ala Ala Pro Gly His Asp Leu 
                85                  90                  95      


Ser Asp Thr Val Gln Ala Asp Leu Ser Lys Asn Arg Leu Val Glu Val 
            100                 105                 110         


Pro Met Glu Leu Cys His Phe Val Ser Leu Glu Ile Leu Asn Leu Tyr 
        115                 120                 125             


His Asn Cys Ile Arg Val Ile Pro Glu Ala Ile Val Asn Leu Gln Met 
    130                 135                 140                 


Leu Thr Tyr Leu Asn Leu Ser Arg Asn Gln Leu Ser Ala Leu Pro Ala 
145                 150                 155                 160 


Cys Leu Cys Gly Leu Pro Leu Lys Val Leu Ile Ala Ser Asn Asn Lys 
                165                 170                 175     


Leu Gly Ser Leu Pro Glu Glu Ile Gly Gln Leu Lys Gln Leu Met Glu 
            180                 185                 190         


Leu Asp Val Ser Cys Asn Glu Ile Thr Ala Leu Pro Gln Gln Ile Gly 
        195                 200                 205             


Gln Leu Lys Ser Leu Arg Glu Leu Asn Val Arg Arg Asn Tyr Leu Lys 
    210                 215                 220                 


Val Leu Pro Gln Glu Leu Val Asp Leu Pro Leu Val Lys Phe Asp Phe 
225                 230                 235                 240 


Ser Cys Asn Lys Val Leu Val Ile Pro Ile Cys Phe Arg Glu Met Lys 
                245                 250                 255     


Gln Leu Gln Val Leu Leu Leu Glu Asn Asn Pro Leu Gln Ser Pro Pro 
            260                 265                 270         


Ala Gln Ile Cys Thr Lys Gly Lys Val His Ile Phe Lys Tyr Leu Ser 
        275                 280                 285             


Ile Gln Ala Cys Gln Ile Lys Thr Ala Asp Ser Leu Tyr Leu His Thr 
    290                 295                 300                 


Met Glu Arg Pro His Leu His Gln His Val Glu Asp Gly Lys Lys Asp 
305                 310                 315                 320 


Ser Asp Ser Gly Val Gly Ser Asp Asn Gly Asp Lys Arg Leu Ser Ala 
                325                 330                 335     


Thr Glu Pro Ser Asp Glu Asp Thr Val Ser Leu Asn Val Pro Met Ser 
            340                 345                 350         


Asn Ile Met Glu Glu Glu Gln Ile Ile Lys Glu Asp Ser Cys His Arg 
        355                 360                 365             


Leu Ser Pro Val Lys Gly Glu Phe His Gln Glu Phe Gln Pro Glu Pro 
    370                 375                 380                 


Ser Leu Leu Gly Asp Ser Thr Asn Ser Gly Glu Glu Arg Asp Gln Phe 
385                 390                 395                 400 


Thr Asp Arg Ala Asp Gly Leu His Ser Glu Phe Met Asn Tyr Lys Ala 
                405                 410                 415     


Arg Ala Glu Asp Cys Glu Glu Leu Leu Arg Ile Glu Glu Asp Val His 
            420                 425                 430         


Trp Gln Thr Glu Gly Ile Ile Ser Ser Ser Lys Asp Gln Asp Met Asp 
        435                 440                 445             


Ile Ala Met Ile Glu Gln Leu Arg Glu Ala Val Asp Leu Leu Gln Asp 
    450                 455                 460                 


Pro Asn Gly Leu Ser Thr Asp Ile Thr Glu Arg Ser Val Leu Asn Leu 
465                 470                 475                 480 


Tyr Pro Met Gly Ser Ala Glu Ala Leu Glu Leu Gln Asp Ser Ala Leu 
                485                 490                 495     


Asn Gly Gln Ile Gln Leu Glu Thr Ser Pro Val Cys Glu Val Gln Ser 
            500                 505                 510         


Asp Leu Thr Leu Gln Ser Asn Gly Ser Gln Tyr Ser Pro Asn Glu Ile 
        515                 520                 525             


Arg Glu Asn Ser Pro Ala Val Ser Pro Thr Thr Asn Ser Thr Ala Pro 
    530                 535                 540                 


Phe Gly Leu Lys Pro Arg Ser Val Phe Leu Arg Pro Gln Arg Asn Leu 
545                 550                 555                 560 


Glu Ser Ile Asp Pro Gln Phe Thr Ile Arg Arg Lys Met Glu Gln Met 
                565                 570                 575     


Arg Glu Glu Lys Glu Leu Val Glu Gln Leu Arg Glu Ser Ile Glu Met 
            580                 585                 590         


Arg Leu Lys Val Ser Leu His Glu Asp Leu Gly Ala Ala Leu Met Asp 
        595                 600                 605             


Gly Val Val Leu Cys His Leu Val Asn His Ile Arg Pro Arg Ser Val 
    610                 615                 620                 


Ala Ser Ile His Val Pro Ser Pro Ala Val Pro Lys Leu Ser Met Ala 
625                 630                 635                 640 


Lys Cys Arg Arg Asn Val Glu Asn Phe Leu Glu Ala Cys Arg Lys Leu 
                645                 650                 655     


Gly Val Pro Glu Ala Asp Leu Cys Ser Pro Cys Asp Ile Leu Gln Leu 
            660                 665                 670         


Asp Phe Arg His Ile Arg Lys Thr Val Asp Thr Leu Leu Ala Leu Gly 
        675                 680                 685             


Glu Lys Ala Pro Pro Pro Thr Ser Ala Leu Arg Ser Arg Asp Leu Ile 
    690                 695                 700                 


Gly Phe Cys Leu Val His Ile Leu Phe Ile Val Leu Val Tyr Ile Thr 
705                 710                 715                 720 


Tyr His Trp Asn Ala Leu Ser Ala 
                725             


<210>  4036
<211>  578
<212>  PRT
<213>  Homo sapiens

<400>  4036

Met Leu Arg Arg Leu Asp Lys Ile Arg Phe Arg Gly His Lys Arg Asp 
1               5                   10                  15      


Asp Phe Leu Asp Leu Ala Glu Ser Pro Asn Ala Ser Asp Thr Glu Cys 
            20                  25                  30          


Ser Asp Glu Ile Pro Leu Lys Val Pro Arg Thr Ser Pro Arg Asp Ser 
        35                  40                  45              


Glu Glu Leu Arg Asp Pro Ala Gly Pro Gly Thr Leu Ile Met Ala Thr 
    50                  55                  60                  


Gly Val Gln Asp Phe Asn Arg Thr Glu Phe Asp Arg Leu Asn Glu Ile 
65                  70                  75                  80  


Lys Gly His Leu Glu Ile Ala Leu Leu Glu Lys His Phe Leu Gln Glu 
                85                  90                  95      


Glu Leu Arg Lys Leu Arg Glu Glu Thr Asn Ala Glu Met Leu Arg Gln 
            100                 105                 110         


Glu Leu Asp Arg Glu Arg Gln Arg Arg Met Glu Leu Glu Gln Lys Val 
        115                 120                 125             


Gln Glu Val Leu Lys Ala Arg Thr Glu Glu Gln Met Ala Gln Gln Pro 
    130                 135                 140                 


Pro Lys Gly Gln Ala Gln Ala Ser Asn Gly Ala Glu Arg Arg Ser Gln 
145                 150                 155                 160 


Gly Leu Ser Ser Arg Leu Gln Lys Trp Phe Tyr Glu Arg Phe Gly Glu 
                165                 170                 175     


Tyr Val Glu Asp Phe Arg Phe Gln Pro Glu Glu Asn Thr Val Glu Thr 
            180                 185                 190         


Glu Glu Pro Leu Ser Ala Arg Arg Leu Thr Glu Asn Met Arg Arg Leu 
        195                 200                 205             


Lys Arg Gly Ala Lys Pro Val Thr Asn Phe Val Lys Asn Leu Ser Ala 
    210                 215                 220                 


Leu Ser Asp Trp Tyr Ser Val Tyr Thr Ser Ala Ile Ala Phe Thr Val 
225                 230                 235                 240 


Tyr Met Asn Ala Val Trp His Gly Trp Ala Ile Pro Leu Phe Leu Phe 
                245                 250                 255     


Leu Ala Ile Leu Arg Leu Ser Leu Asn Tyr Leu Ile Ala Arg Gly Trp 
            260                 265                 270         


Arg Ile Gln Trp Ser Ile Val Pro Glu Val Ser Glu Pro Val Glu Pro 
        275                 280                 285             


Pro Lys Glu Asp Leu Thr Val Ser Glu Lys Phe Gln Leu Val Leu Asp 
    290                 295                 300                 


Val Ala Gln Lys Ala Gln Asn Leu Phe Gly Lys Met Ala Asp Ile Leu 
305                 310                 315                 320 


Glu Lys Ile Lys Asn Leu Phe Met Trp Val Gln Pro Glu Ile Thr Gln 
                325                 330                 335     


Lys Leu Tyr Val Ala Leu Trp Ala Ala Phe Leu Ala Ser Cys Phe Phe 
            340                 345                 350         


Pro Tyr Arg Leu Val Gly Leu Ala Val Gly Leu Tyr Ala Gly Ile Lys 
        355                 360                 365             


Phe Phe Leu Ile Asp Phe Ile Phe Lys Arg Cys Pro Arg Leu Arg Ala 
    370                 375                 380                 


Lys Tyr Asp Thr Pro Tyr Ile Ile Trp Arg Ser Leu Pro Thr Asp Pro 
385                 390                 395                 400 


Gln Leu Lys Glu Arg Ser Ser Ala Ala Val Ser Arg Arg Leu Gln Thr 
                405                 410                 415     


Thr Ser Ser Arg Ser Tyr Val Pro Ser Ala Pro Ala Gly Leu Gly Lys 
            420                 425                 430         


Glu Glu Asp Ala Gly Arg Phe His Ser Thr Lys Lys Gly Asn Phe His 
        435                 440                 445             


Glu Ile Phe Asn Leu Thr Glu Asn Glu Arg Pro Leu Ala Val Cys Glu 
    450                 455                 460                 


Asn Gly Trp Arg Cys Cys Leu Ile Asn Arg Asp Arg Lys Met Pro Thr 
465                 470                 475                 480 


Asp Tyr Ile Arg Asn Gly Val Leu Tyr Val Thr Glu Asn Tyr Leu Cys 
                485                 490                 495     


Phe Glu Ser Ser Lys Ser Gly Ser Ser Lys Arg Asn Lys Val Ile Lys 
            500                 505                 510         


Leu Val Asp Ile Thr Asp Ile Gln Lys Tyr Lys Val Leu Ser Val Leu 
        515                 520                 525             


Pro Gly Ser Gly Met Gly Ile Ala Val Ser Thr Pro Ser Thr Gln Lys 
    530                 535                 540                 


Pro Leu Val Phe Gly Ala Met Val His Arg Asp Glu Ala Phe Glu Thr 
545                 550                 555                 560 


Ile Leu Ser Gln Tyr Ile Lys Ile Thr Ser Ala Ala Ala Ser Gly Gly 
                565                 570                 575     


Asp Ser 
        


<210>  4037
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  4037

Met Leu Cys Ser Leu Leu Leu Cys Glu Cys Leu Leu Leu Val Ala Gly 
1               5                   10                  15      


Tyr Ala His Asp Asp Asp Trp Ile Asp Pro Thr Asp Met Leu Asn Tyr 
            20                  25                  30          


Asp Ala Ala Ser Gly Thr Met Arg Lys Ser Gln Ala Lys Tyr Gly Ile 
        35                  40                  45              


Ser Gly Glu Lys Asp Val Ser Pro Asp Leu Ser Cys Ala Asp Glu Ile 
    50                  55                  60                  


Ser Glu Cys Tyr His Lys Leu Asp Ser Leu Thr Tyr Lys Ile Asp Glu 
65                  70                  75                  80  


Cys Glu Lys Lys Lys Arg Glu Asp Tyr Glu Ser Gln Ser Asn Pro Val 
                85                  90                  95      


Phe Arg Arg Tyr Leu Asn Lys Ile Leu Ile Glu Ala Gly Lys Leu Gly 
            100                 105                 110         


Leu Phe His Asp Phe Glu Thr Trp Lys Trp Arg Phe Glu Asp Ser Phe 
        115                 120                 125             


Gly Val Asp Pro Tyr Asn Val Leu Met Val Leu Leu Cys Leu Leu Cys 
    130                 135                 140                 


Ile Val Val Leu Val Ala Thr Glu Leu Trp Thr Tyr Val Arg Trp Tyr 
145                 150                 155                 160 


Thr Gln Leu Arg Arg Val Leu Ile Ile Ser Phe Leu Phe Ser Leu Gly 
                165                 170                 175     


Trp Asn Trp Met Tyr Leu Tyr Lys Leu Ala Phe Ala Gln His Gln Ala 
            180                 185                 190         


Glu Val Ala Lys Met Glu Pro Leu Asn Asn Val Cys Ala Lys Lys Met 
        195                 200                 205             


Asp Trp Thr Gly Ser Ile Trp Glu Trp Phe Arg Ser Ser Trp Thr Tyr 
    210                 215                 220                 


Lys Asp Asp Pro Cys Gln Lys Tyr Tyr Glu Leu Leu Leu Val Asn Pro 
225                 230                 235                 240 


Ile Trp Leu Val Pro Pro Thr Lys Ala Leu Ala Val Thr Phe Thr Thr 
                245                 250                 255     


Phe Val Thr Glu Pro Leu Lys His Ile Gly Lys Gly Thr Gly Glu Phe 
            260                 265                 270         


Ile Lys Ala Leu Met Lys Glu Ile Pro Ala Leu Leu His Leu Pro Val 
        275                 280                 285             


Leu Ile Ile Met Ala Leu Ala Ile Leu Ser Phe Cys Tyr Gly Ala Gly 
    290                 295                 300                 


Lys Ser Val His Val Leu Arg His Ile Gly Gly Pro Glu Ser Glu Pro 
305                 310                 315                 320 


Pro Gln Ala Leu Arg Pro Arg Asp Arg Arg Arg Gln Glu Glu Ile Asp 
                325                 330                 335     


Tyr Arg Pro Asp Gly Gly Ala Gly Asp Ala Asp Phe His Tyr Arg Gly 
            340                 345                 350         


Gln Met Gly Pro Thr Glu Gln Gly Pro Tyr Ala Lys Thr Tyr Glu Gly 
        355                 360                 365             


Arg Arg Glu Ile Leu Arg Glu Arg Asp Val Asp Leu Arg Phe Gln Thr 
    370                 375                 380                 


Gly Asn Lys Ser Pro Glu Val Leu Arg Ala Phe Asp Val Pro Asp Ala 
385                 390                 395                 400 


Glu Ala Arg Glu His Pro Thr Val Val Pro Ser His Lys Ser Pro Val 
                405                 410                 415     


Leu Asp Thr Lys Pro Lys Glu Thr Gly Gly Ile Leu Gly Glu Gly Thr 
            420                 425                 430         


Pro Lys Glu Ser Ser Thr Glu Ser Ser Gln Ser Ala Lys Pro Val Ser 
        435                 440                 445             


Gly Gln Asp Thr Ser Gly Asn Thr Glu Gly Ser Pro Ala Ala Glu Lys 
    450                 455                 460                 


Ala Gln Leu Lys Ser Glu Ala Ala Gly Ser Pro Asp Gln Gly Ser Thr 
465                 470                 475                 480 


Tyr Ser Pro Ala Arg Gly Val Ala Gly Pro Arg Gly Gln Asp Pro Val 
                485                 490                 495     


Ser Ser Pro Cys Gly 
            500     


<210>  4038
<211>  957
<212>  PRT
<213>  Homo sapiens

<400>  4038

Met Leu Thr Glu Ala Ser Leu Ser Ile Trp Gly Trp Gly Ser Leu Gly 
1               5                   10                  15      


Ile Val Leu Phe Leu Ile Thr Phe Gly Pro Phe Val Ile Phe Tyr Leu 
            20                  25                  30          


Thr Phe Tyr Ile Leu Cys Phe Val Gly Gly Gly Leu Val Val Thr Leu 
        35                  40                  45              


Leu Phe Gly Lys Thr Asn Ser Glu Lys Tyr Leu Glu Gln Cys Glu His 
    50                  55                  60                  


Ser Phe Leu Pro Pro Thr Ser Pro Gly Val Pro Lys Cys Leu Glu Glu 
65                  70                  75                  80  


Met Lys Arg Glu Ala Arg Thr Ile Lys Ile Asp Arg Arg Leu Thr Gly 
                85                  90                  95      


Ala Asn Ile Ile Asp Glu Pro Leu Gln Gln Val Ile Gln Phe Ser Leu 
            100                 105                 110         


Arg Asp Tyr Val Gln Tyr Trp Tyr Tyr Thr Leu Ser Asp Asp Glu Ser 
        115                 120                 125             


Phe Leu Leu Glu Ile Arg Gln Thr Leu Gln Asn Ala Leu Ile Gln Phe 
    130                 135                 140                 


Ala Thr Arg Ser Lys Glu Ile Asp Trp Gln Pro Tyr Phe Thr Thr Arg 
145                 150                 155                 160 


Ile Val Asp Asp Phe Gly Thr His Leu Arg Val Phe Arg Lys Ala Gln 
                165                 170                 175     


Gln Lys Ile Thr Glu Lys Asp Asp Gln Val Lys Gly Thr Ala Glu Asp 
            180                 185                 190         


Leu Val Asp Thr Phe Phe Glu Val Glu Val Glu Met Glu Lys Glu Val 
        195                 200                 205             


Cys Arg Asp Leu Val Cys Thr Ser Pro Lys Asp Glu Glu Gly Phe Leu 
    210                 215                 220                 


Arg Asp Leu Cys Glu Val Leu Leu Tyr Leu Leu Leu Pro Pro Gly Asp 
225                 230                 235                 240 


Phe Gln Asn Lys Ile Met Arg Tyr Phe Val Arg Glu Ile Leu Ala Arg 
                245                 250                 255     


Gly Ile Leu Leu Pro Leu Ile Asn Gln Leu Ser Asp Pro Asp Tyr Ile 
            260                 265                 270         


Asn Gln Tyr Val Ile Trp Met Ile Arg Asp Ser Asn Cys Asn Tyr Glu 
        275                 280                 285             


Ala Phe Met Asn Ile Ile Lys Leu Ser Asp Asn Ile Gly Glu Leu Glu 
    290                 295                 300                 


Ala Val Arg Asp Lys Ala Ala Glu Glu Leu Gln Tyr Leu Arg Ser Leu 
305                 310                 315                 320 


Asp Thr Ala Gly Asp Asp Ile Asn Thr Ile Lys Asn Gln Ile Asn Ser 
                325                 330                 335     


Leu Leu Phe Val Lys Lys Val Cys Asp Ser Arg Ile Gln Arg Leu Gln 
            340                 345                 350         


Ser Gly Lys Glu Ile Asn Thr Val Lys Leu Ala Ala Asn Phe Gly Lys 
        355                 360                 365             


Leu Cys Thr Val Pro Leu Asp Ser Ile Leu Val Asp Asn Val Ala Leu 
    370                 375                 380                 


Gln Phe Phe Met Asp Tyr Met Gln Gln Thr Gly Gly Gln Ala His Leu 
385                 390                 395                 400 


Phe Phe Trp Met Thr Val Glu Gly Tyr Arg Val Thr Ala Gln Gln Gln 
                405                 410                 415     


Leu Glu Val Leu Leu Ser Arg Gln Arg Asp Gly Lys His Gln Thr Asn 
            420                 425                 430         


Gln Thr Lys Gly Leu Leu Arg Ala Ala Ala Val Gly Ile Tyr Glu Gln 
        435                 440                 445             


Tyr Leu Ser Glu Lys Ala Ser Pro Arg Val Thr Val Asp Asp Tyr Leu 
    450                 455                 460                 


Val Ala Lys Leu Ala Asp Thr Leu Asn His Glu Asp Pro Thr Pro Glu 
465                 470                 475                 480 


Ile Phe Asp Asp Ile Gln Arg Lys Val Tyr Glu Leu Met Leu Arg Asp 
                485                 490                 495     


Glu Arg Phe Tyr Pro Ser Phe Arg Gln Asn Ala Leu Tyr Val Arg Met 
            500                 505                 510         


Leu Ala Glu Leu Asp Met Leu Lys Asp Pro Ser Phe Arg Gly Ser Asp 
        515                 520                 525             


Asp Gly Asp Gly Glu Ser Phe Asn Gly Ser Pro Thr Gly Ser Ile Asn 
    530                 535                 540                 


Leu Ser Leu Asp Asp Leu Ser Asn Val Ser Ser Asp Asp Ser Val Gln 
545                 550                 555                 560 


Leu His Ala Tyr Ile Ser Asp Thr Gly Val Cys Asn Asp His Gly Lys 
                565                 570                 575     


Thr Tyr Ala Leu Tyr Ala Ile Thr Val His Arg Arg Asn Leu Asn Ser 
            580                 585                 590         


Glu Glu Met Trp Lys Thr Tyr Arg Arg Tyr Ser Asp Phe His Asp Phe 
        595                 600                 605             


His Met Arg Ile Thr Glu Gln Phe Glu Ser Leu Ser Ser Ile Leu Lys 
    610                 615                 620                 


Leu Pro Gly Lys Lys Thr Phe Asn Asn Met Asp Arg Asp Phe Leu Glu 
625                 630                 635                 640 


Lys Arg Lys Lys Asp Leu Asn Ala Tyr Leu Gln Leu Leu Leu Ala Pro 
                645                 650                 655     


Glu Met Met Lys Ala Ser Pro Ala Leu Ala His Tyr Val Tyr Asp Phe 
            660                 665                 670         


Leu Glu Asn Lys Ala Tyr Ser Lys Gly Lys Gly Asp Phe Ala Arg Lys 
        675                 680                 685             


Met Asp Thr Phe Val Asn Pro Leu Arg Asn Ser Met Arg Asn Val Ser 
    690                 695                 700                 


Asn Ala Val Lys Ser Leu Pro Asp Ser Leu Ala Glu Gly Met Thr Lys 
705                 710                 715                 720 


Met Ser Asp Asn Met Gly Lys Met Ser Glu Arg Leu Gly Gln Asp Ile 
                725                 730                 735     


Lys Gln Ser Phe Phe Lys Val Pro Pro Leu Ile Pro Lys Thr Asp Ser 
            740                 745                 750         


Asp Pro Glu His Arg Arg Val Ser Ala Gln Leu Asp Asp Asn Val Asp 
        755                 760                 765             


Asp Asn Ile Pro Leu Arg Val Met Leu Leu Leu Met Asp Glu Val Phe 
    770                 775                 780                 


Asp Leu Lys Glu Arg Asn Gln Trp Leu Arg Arg Asn Ile Lys Asn Leu 
785                 790                 795                 800 


Leu Gln Gln Leu Ile Arg Ala Thr Tyr Gly Asp Thr Ile Asn Arg Lys 
                805                 810                 815     


Ile Val Asp His Val Asp Trp Met Thr Ser Pro Glu Gln Val Ala Asp 
            820                 825                 830         


Ser Val Lys Arg Phe Arg Asp Ala Phe Trp Pro Asn Gly Ile Leu Ala 
        835                 840                 845             


Glu Ala Val Pro Cys Arg Asp Lys Ser Ile Arg Met Arg Thr Arg Val 
    850                 855                 860                 


Ala Gly Lys Thr Lys Leu Leu Ala Ile Met Pro Asp Glu Leu Lys His 
865                 870                 875                 880 


Ile Ile Gly Ala Glu Thr Thr Arg Lys Gly Ile Leu Arg Val Phe Glu 
                885                 890                 895     


Met Phe Gln His Asn Gln Leu Asn Arg Arg Met Val Tyr Val Phe Leu 
            900                 905                 910         


Glu Gly Phe Leu Glu Thr Leu Phe Pro Gln Tyr Lys Phe Arg Glu Leu 
        915                 920                 925             


Phe Asn Lys Leu His Ser Arg Ser Lys Gln Met Gln Lys Tyr Lys Gln 
    930                 935                 940                 


Lys Leu Gln Thr Thr Gln Ala Pro Ser Leu Gln Lys Arg 
945                 950                 955         


<210>  4039
<211>  2570
<212>  PRT
<213>  Homo sapiens

<400>  4039

Met Ala Gly Pro Arg Gly Leu Leu Pro Leu Cys Leu Leu Ala Phe Cys 
1               5                   10                  15      


Leu Ala Gly Phe Ser Phe Val Arg Gly Gln Val Leu Phe Lys Gly Cys 
            20                  25                  30          


Asp Val Lys Thr Thr Phe Val Thr His Val Pro Cys Thr Ser Cys Ala 
        35                  40                  45              


Ala Ile Lys Lys Gln Thr Cys Pro Ser Gly Trp Leu Arg Glu Leu Pro 
    50                  55                  60                  


Asp Gln Ile Thr Gln Asp Cys Arg Tyr Glu Val Gln Leu Gly Gly Ser 
65                  70                  75                  80  


Met Val Ser Met Ser Gly Cys Arg Arg Lys Cys Arg Lys Gln Val Val 
                85                  90                  95      


Gln Lys Ala Cys Cys Pro Gly Tyr Trp Gly Ser Arg Cys His Glu Cys 
            100                 105                 110         


Pro Gly Gly Ala Glu Thr Pro Cys Asn Gly His Gly Thr Cys Leu Asp 
        115                 120                 125             


Gly Met Asp Arg Asn Gly Thr Cys Val Cys Gln Glu Asn Phe Arg Gly 
    130                 135                 140                 


Ser Ala Cys Gln Glu Cys Gln Asp Pro Asn Arg Phe Gly Pro Asp Cys 
145                 150                 155                 160 


Gln Ser Val Cys Ser Cys Val His Gly Val Cys Asn His Gly Pro Arg 
                165                 170                 175     


Gly Asp Gly Ser Cys Leu Cys Phe Ala Gly Tyr Thr Gly Pro His Cys 
            180                 185                 190         


Asp Gln Glu Leu Pro Val Cys Gln Glu Leu Arg Cys Pro Gln Asn Thr 
        195                 200                 205             


Gln Cys Ser Ala Glu Ala Pro Ser Cys Arg Cys Leu Pro Gly Tyr Thr 
    210                 215                 220                 


Gln Gln Gly Ser Glu Cys Arg Ala Pro Asn Pro Cys Trp Pro Ser Pro 
225                 230                 235                 240 


Cys Ser Leu Leu Ala Gln Cys Ser Val Ser Pro Lys Gly Gln Ala Gln 
                245                 250                 255     


Cys His Cys Pro Glu Asn Tyr His Gly Asp Gly Met Val Cys Leu Pro 
            260                 265                 270         


Lys Asp Pro Cys Thr Asp Asn Leu Gly Gly Cys Pro Ser Asn Ser Thr 
        275                 280                 285             


Leu Cys Val Tyr Gln Lys Pro Gly Gln Ala Phe Cys Thr Cys Arg Pro 
    290                 295                 300                 


Gly Leu Val Ser Ile Asn Ser Asn Ala Ser Ala Gly Cys Phe Ala Phe 
305                 310                 315                 320 


Cys Ser Pro Phe Ser Cys Asp Arg Ser Ala Thr Cys Gln Val Thr Ala 
                325                 330                 335     


Asp Gly Lys Thr Ser Cys Val Cys Arg Glu Ser Glu Val Gly Asp Gly 
            340                 345                 350         


Arg Ala Cys Tyr Gly His Leu Leu His Glu Val Gln Lys Ala Thr Gln 
        355                 360                 365             


Thr Gly Arg Val Phe Leu Gln Leu Arg Val Ala Val Ala Met Met Asp 
    370                 375                 380                 


Gln Gly Cys Arg Glu Ile Leu Thr Thr Ala Gly Pro Phe Thr Val Leu 
385                 390                 395                 400 


Val Pro Ser Val Ser Ser Phe Ser Ser Arg Thr Met Asn Ala Ser Leu 
                405                 410                 415     


Ala Gln Gln Leu Cys Arg Gln His Ile Ile Ala Gly Gln His Ile Leu 
            420                 425                 430         


Glu Asp Thr Arg Thr Gln Gln Thr Arg Arg Trp Trp Thr Leu Ala Gly 
        435                 440                 445             


Gln Glu Ile Thr Val Thr Phe Asn Gln Phe Thr Lys Tyr Ser Tyr Lys 
    450                 455                 460                 


Tyr Lys Asp Gln Pro Gln Gln Thr Phe Asn Ile Tyr Lys Ala Asn Asn 
465                 470                 475                 480 


Ile Ala Ala Asn Gly Val Phe His Val Val Thr Gly Leu Arg Trp Gln 
                485                 490                 495     


Ala Pro Ser Gly Thr Pro Gly Asp Pro Lys Arg Thr Ile Gly Gln Ile 
            500                 505                 510         


Leu Ala Ser Thr Glu Ala Phe Ser Arg Phe Glu Thr Ile Leu Glu Asn 
        515                 520                 525             


Cys Gly Leu Pro Ser Ile Leu Asp Gly Pro Gly Pro Phe Thr Val Phe 
    530                 535                 540                 


Ala Pro Ser Asn Glu Ala Val Asp Ser Leu Arg Asp Gly Arg Leu Ile 
545                 550                 555                 560 


Tyr Leu Phe Thr Ala Gly Leu Ser Lys Leu Gln Glu Leu Val Arg Tyr 
                565                 570                 575     


His Ile Tyr Asn His Gly Gln Leu Thr Val Glu Lys Leu Ile Ser Lys 
            580                 585                 590         


Gly Arg Ile Leu Thr Met Ala Asn Gln Val Leu Ala Val Asn Ile Ser 
        595                 600                 605             


Glu Glu Gly Arg Ile Leu Leu Gly Pro Glu Gly Val Pro Leu Gln Arg 
    610                 615                 620                 


Val Asp Val Met Ala Ala Asn Gly Val Ile His Met Leu Asp Gly Ile 
625                 630                 635                 640 


Leu Leu Pro Pro Thr Ile Leu Pro Ile Leu Pro Lys His Cys Ser Glu 
                645                 650                 655     


Glu Gln His Lys Ile Val Ala Gly Ser Cys Val Asp Cys Gln Ala Leu 
            660                 665                 670         


Asn Thr Ser Thr Cys Pro Pro Asn Ser Val Lys Leu Asp Ile Phe Pro 
        675                 680                 685             


Lys Glu Cys Val Tyr Ile His Asp Pro Thr Gly Leu Asn Val Leu Lys 
    690                 695                 700                 


Lys Gly Cys Ala Ser Tyr Cys Asn Gln Thr Ile Met Glu Gln Gly Cys 
705                 710                 715                 720 


Cys Lys Gly Phe Phe Gly Pro Asp Cys Thr Gln Cys Pro Gly Gly Phe 
                725                 730                 735     


Ser Asn Pro Cys Tyr Gly Lys Gly Asn Cys Ser Asp Gly Ile Gln Gly 
            740                 745                 750         


Asn Gly Ala Cys Leu Cys Phe Pro Asp Tyr Lys Gly Ile Ala Cys His 
        755                 760                 765             


Ile Cys Ser Asn Pro Asn Lys His Gly Glu Gln Cys Gln Glu Asp Cys 
    770                 775                 780                 


Gly Cys Val His Gly Leu Cys Asp Asn Arg Pro Gly Ser Gly Gly Val 
785                 790                 795                 800 


Cys Gln Gln Gly Thr Cys Ala Pro Gly Phe Ser Gly Arg Phe Cys Asn 
                805                 810                 815     


Glu Ser Met Gly Asp Cys Gly Pro Thr Gly Leu Ala Gln His Cys His 
            820                 825                 830         


Leu His Ala Arg Cys Val Ser Gln Glu Gly Val Ala Arg Cys Arg Cys 
        835                 840                 845             


Leu Asp Gly Phe Glu Gly Asp Gly Phe Ser Cys Thr Pro Ser Asn Pro 
    850                 855                 860                 


Cys Ser His Pro Asp Arg Gly Gly Cys Ser Glu Asn Ala Glu Cys Val 
865                 870                 875                 880 


Pro Gly Ser Leu Gly Thr His His Cys Thr Cys His Lys Gly Trp Ser 
                885                 890                 895     


Gly Asp Gly Arg Val Cys Val Ala Ile Asp Glu Cys Glu Leu Asp Met 
            900                 905                 910         


Arg Gly Gly Cys His Thr Asp Ala Leu Cys Ser Tyr Val Gly Pro Gly 
        915                 920                 925             


Gln Ser Arg Cys Thr Cys Lys Leu Gly Phe Ala Gly Asp Gly Tyr Gln 
    930                 935                 940                 


Cys Ser Pro Ile Asp Pro Cys Arg Ala Gly Asn Gly Gly Cys His Gly 
945                 950                 955                 960 


Leu Ala Thr Cys Arg Ala Val Gly Gly Gly Gln Arg Val Cys Thr Cys 
                965                 970                 975     


Pro Pro Gly Phe Gly Gly Asp Gly Phe Ser Cys Tyr Gly Asp Ile Phe 
            980                 985                 990         


Arg Glu Leu Glu Ala Asn Ala His  Phe Ser Ile Phe Tyr  Gln Trp Leu 
        995                 1000                 1005             


Lys Ser  Ala Gly Ile Thr Leu  Pro Ala Asp Arg Arg  Val Thr Ala 
    1010                 1015                 1020             


Leu Val  Pro Ser Glu Ala Ala  Val Arg Gln Leu Ser  Pro Glu Asp 
    1025                 1030                 1035             


Arg Ala  Phe Trp Leu Gln Pro  Arg Thr Leu Pro Asn  Leu Val Arg 
    1040                 1045                 1050             


Ala His  Phe Leu Gln Gly Ala  Leu Phe Glu Glu Glu  Leu Ala Arg 
    1055                 1060                 1065             


Leu Gly  Gly Gln Glu Val Ala  Thr Leu Asn Pro Thr  Thr Arg Trp 
    1070                 1075                 1080             


Glu Ile  Arg Asn Ile Ser Gly  Arg Val Trp Val Gln  Asn Ala Ser 
    1085                 1090                 1095             


Val Asp  Val Ala Asp Leu Leu  Ala Thr Asn Gly Val  Leu His Ile 
    1100                 1105                 1110             


Leu Ser  Gln Val Leu Leu Pro  Pro Arg Gly Asp Val  Pro Gly Gly 
    1115                 1120                 1125             


Gln Gly  Leu Leu Gln Gln Leu  Asp Leu Val Pro Ala  Phe Ser Leu 
    1130                 1135                 1140             


Phe Arg  Glu Leu Leu Gln His  His Gly Leu Val Pro  Gln Ile Glu 
    1145                 1150                 1155             


Ala Ala  Thr Ala Tyr Thr Ile  Phe Val Pro Thr Asn  Arg Ser Leu 
    1160                 1165                 1170             


Glu Ala  Gln Gly Asn Ser Ser  His Leu Asp Ala Asp  Thr Val Arg 
    1175                 1180                 1185             


His His  Val Val Leu Gly Glu  Ala Leu Ser Met Glu  Thr Leu Arg 
    1190                 1195                 1200             


Lys Gly  Gly His Arg Asn Ser  Leu Leu Gly Pro Ala  His Trp Ile 
    1205                 1210                 1215             


Val Phe  Tyr Asn His Ser Gly  Gln Pro Glu Val Asn  His Val Pro 
    1220                 1225                 1230             


Leu Glu  Gly Pro Met Leu Glu  Ala Pro Gly Arg Ser  Leu Ile Gly 
    1235                 1240                 1245             


Leu Ser  Gly Val Leu Thr Val  Gly Ser Ser Arg Cys  Leu His Ser 
    1250                 1255                 1260             


His Ala  Glu Ala Leu Arg Glu  Lys Cys Val Asn Cys  Thr Arg Arg 
    1265                 1270                 1275             


Phe Arg  Cys Thr Gln Gly Phe  Gln Leu Gln Asp Thr  Pro Arg Lys 
    1280                 1285                 1290             


Ser Cys  Val Tyr Arg Ser Gly  Phe Ser Phe Ser Arg  Gly Cys Ser 
    1295                 1300                 1305             


Tyr Thr  Cys Ala Lys Lys Ile  Gln Val Pro Asp Cys  Cys Pro Gly 
    1310                 1315                 1320             


Phe Phe  Gly Thr Leu Cys Glu  Pro Cys Pro Gly Gly  Leu Gly Gly 
    1325                 1330                 1335             


Val Cys  Ser Gly His Gly Gln  Cys Gln Asp Arg Phe  Leu Gly Ser 
    1340                 1345                 1350             


Gly Glu  Cys His Cys His Glu  Gly Phe His Gly Thr  Ala Cys Glu 
    1355                 1360                 1365             


Val Cys  Glu Leu Gly Arg Tyr  Gly Pro Asn Cys Thr  Gly Val Cys 
    1370                 1375                 1380             


Asp Cys  Ala His Gly Leu Cys  Gln Glu Gly Leu Gln  Gly Asp Gly 
    1385                 1390                 1395             


Ser Cys  Val Cys Asn Val Gly  Trp Gln Gly Leu Arg  Cys Asp Gln 
    1400                 1405                 1410             


Lys Ile  Thr Ser Pro Gln Cys  Pro Arg Lys Cys Asp  Pro Asn Ala 
    1415                 1420                 1425             


Asn Cys  Val Gln Asp Ser Ala  Gly Ala Ser Thr Cys  Ala Cys Ala 
    1430                 1435                 1440             


Ala Gly  Tyr Ser Gly Asn Gly  Ile Phe Cys Ser Glu  Val Asp Pro 
    1445                 1450                 1455             


Cys Ala  His Gly His Gly Gly  Cys Ser Pro His Ala  Asn Cys Thr 
    1460                 1465                 1470             


Lys Val  Ala Pro Gly Gln Arg  Thr Cys Thr Cys Gln  Asp Gly Tyr 
    1475                 1480                 1485             


Met Gly  Asp Gly Glu Leu Cys  Gln Glu Ile Asn Ser  Cys Leu Ile 
    1490                 1495                 1500             


His His  Gly Gly Cys His Ile  His Ala Glu Cys Ile  Pro Thr Gly 
    1505                 1510                 1515             


Pro Gln  Gln Val Ser Cys Ser  Cys Arg Glu Gly Tyr  Ser Gly Asp 
    1520                 1525                 1530             


Gly Ile  Arg Thr Cys Glu Leu  Leu Asp Pro Cys Ser  Lys Asn Asn 
    1535                 1540                 1545             


Gly Gly  Cys Ser Pro Tyr Ala  Thr Cys Lys Ser Thr  Gly Asp Gly 
    1550                 1555                 1560             


Gln Arg  Thr Cys Thr Cys Asp  Thr Ala His Thr Val  Gly Asp Gly 
    1565                 1570                 1575             


Leu Thr  Cys Arg Ala Arg Val  Gly Leu Glu Leu Leu  Arg Asp Lys 
    1580                 1585                 1590             


His Ala  Ser Phe Phe Ser Leu  Arg Leu Leu Glu Tyr  Lys Glu Leu 
    1595                 1600                 1605             


Lys Gly  Asp Gly Pro Phe Thr  Ile Phe Val Pro His  Ala Asp Leu 
    1610                 1615                 1620             


Met Ser  Asn Leu Ser Gln Asp  Glu Leu Ala Arg Ile  Arg Ala His 
    1625                 1630                 1635             


Arg Gln  Leu Val Phe Arg Tyr  His Val Val Gly Cys  Arg Arg Leu 
    1640                 1645                 1650             


Arg Ser  Glu Asp Leu Leu Glu  Gln Gly Tyr Ala Thr  Ala Leu Ser 
    1655                 1660                 1665             


Gly His  Pro Leu Arg Phe Ser  Glu Arg Glu Gly Ser  Ile Tyr Leu 
    1670                 1675                 1680             


Asn Asp  Phe Ala Arg Val Val  Ser Ser Asp His Glu  Ala Val Asn 
    1685                 1690                 1695             


Gly Ile  Leu His Phe Ile Asp  Arg Val Leu Leu Pro  Pro Glu Ala 
    1700                 1705                 1710             


Leu His  Trp Glu Pro Asp Asp  Ala Pro Ile Pro Arg  Arg Asn Val 
    1715                 1720                 1725             


Thr Ala  Ala Ala Gln Gly Phe  Gly Tyr Lys Ile Phe  Ser Gly Leu 
    1730                 1735                 1740             


Leu Lys  Val Ala Gly Leu Leu  Pro Leu Leu Arg Glu  Ala Ser His 
    1745                 1750                 1755             


Arg Pro  Phe Thr Met Leu Trp  Pro Thr Asp Ala Ala  Phe Arg Ala 
    1760                 1765                 1770             


Leu Pro  Pro Asp Arg Gln Ala  Trp Leu Tyr His Glu  Asp His Arg 
    1775                 1780                 1785             


Asp Lys  Leu Ala Ala Ile Leu  Arg Gly His Met Ile  Arg Asn Val 
    1790                 1795                 1800             


Glu Ala  Leu Ala Ser Asp Leu  Pro Asn Leu Gly Pro  Leu Arg Thr 
    1805                 1810                 1815             


Met His  Gly Thr Pro Ile Ser  Phe Ser Cys Ser Arg  Thr Arg Ala 
    1820                 1825                 1830             


Gly Glu  Leu Met Val Gly Glu  Asp Asp Ala Arg Ile  Val Gln Arg 
    1835                 1840                 1845             


His Leu  Pro Phe Glu Gly Gly  Leu Ala Tyr Gly Ile  Asp Gln Leu 
    1850                 1855                 1860             


Leu Glu  Pro Pro Gly Leu Gly  Ala Arg Cys Asp His  Phe Glu Thr 
    1865                 1870                 1875             


Arg Pro  Leu Arg Leu Asn Thr  Cys Ser Ile Cys Gly  Leu Glu Pro 
    1880                 1885                 1890             


Pro Cys  Pro Glu Gly Ser Gln  Glu Gln Gly Ser Pro  Glu Ala Cys 
    1895                 1900                 1905             


Trp Arg  Phe Tyr Pro Lys Phe  Trp Thr Ser Pro Pro  Leu His Ser 
    1910                 1915                 1920             


Leu Gly  Leu Arg Ser Val Trp  Val His Pro Ser Leu  Trp Gly Arg 
    1925                 1930                 1935             


Pro Gln  Gly Leu Gly Arg Gly  Cys His Arg Asn Cys  Val Thr Thr 
    1940                 1945                 1950             


Thr Trp  Lys Pro Ser Cys Cys  Pro Gly His Tyr Gly  Ser Glu Cys 
    1955                 1960                 1965             


Gln Ala  Cys Pro Gly Gly Pro  Ser Ser Pro Cys Ser  Asp Arg Gly 
    1970                 1975                 1980             


Val Cys  Met Asp Gly Met Ser  Gly Ser Gly Gln Cys  Leu Cys Arg 
    1985                 1990                 1995             


Ser Gly  Phe Ala Gly Thr Ala  Cys Glu Leu Cys Ala  Pro Gly Ala 
    2000                 2005                 2010             


Phe Gly  Pro His Cys Gln Ala  Cys Arg Cys Thr Val  His Gly Arg 
    2015                 2020                 2025             


Cys Asp  Glu Gly Leu Gly Gly  Ser Gly Ser Cys Phe  Cys Asp Glu 
    2030                 2035                 2040             


Gly Trp  Thr Gly Pro Arg Cys  Glu Val Gln Leu Glu  Leu Gln Pro 
    2045                 2050                 2055             


Val Cys  Thr Pro Pro Cys Ala  Pro Glu Ala Val Cys  Arg Ala Gly 
    2060                 2065                 2070             


Asn Ser  Cys Glu Cys Ser Leu  Gly Tyr Glu Gly Asp  Gly Arg Val 
    2075                 2080                 2085             


Cys Thr  Val Ala Asp Leu Cys  Gln Asp Gly His Gly  Gly Cys Ser 
    2090                 2095                 2100             


Glu His  Ala Asn Cys Ser Gln  Val Gly Thr Met Val  Thr Cys Thr 
    2105                 2110                 2115             


Cys Leu  Pro Asp Tyr Glu Gly  Asp Gly Trp Ser Cys  Arg Ala Arg 
    2120                 2125                 2130             


Asn Pro  Cys Thr Asp Gly His  Arg Gly Gly Cys Ser  Glu His Ala 
    2135                 2140                 2145             


Asn Cys  Leu Ser Thr Gly Leu  Asn Thr Arg Arg Cys  Glu Cys His 
    2150                 2155                 2160             


Ala Gly  Tyr Val Gly Asp Gly  Leu Gln Cys Leu Glu  Glu Ser Glu 
    2165                 2170                 2175             


Pro Pro  Val Asp Arg Cys Leu  Gly Gln Pro Pro Pro  Cys His Ser 
    2180                 2185                 2190             


Asp Ala  Met Cys Thr Asp Leu  His Phe Gln Glu Lys  Arg Ala Gly 
    2195                 2200                 2205             


Val Phe  His Leu Gln Ala Thr  Ser Gly Pro Tyr Gly  Leu Asn Phe 
    2210                 2215                 2220             


Ser Glu  Ala Glu Ala Ala Cys  Glu Ala Gln Gly Ala  Val Leu Ala 
    2225                 2230                 2235             


Ser Phe  Pro Gln Leu Ser Ala  Ala Gln Gln Leu Gly  Phe His Leu 
    2240                 2245                 2250             


Cys Leu  Met Gly Trp Leu Ala  Asn Gly Ser Thr Ala  His Pro Val 
    2255                 2260                 2265             


Val Phe  Pro Val Ala Asp Cys  Gly Asn Gly Arg Val  Gly Ile Val 
    2270                 2275                 2280             


Ser Leu  Gly Ala Arg Lys Asn  Leu Ser Glu Arg Trp  Asp Ala Tyr 
    2285                 2290                 2295             


Cys Phe  Arg Val Gln Asp Val  Ala Cys Arg Cys Arg  Asn Gly Phe 
    2300                 2305                 2310             


Val Gly  Asp Gly Ile Ser Thr  Cys Asn Gly Lys Leu  Leu Asp Val 
    2315                 2320                 2325             


Leu Ala  Ala Thr Ala Asn Phe  Ser Thr Phe Tyr Gly  Met Leu Leu 
    2330                 2335                 2340             


Gly Tyr  Ala Asn Ala Thr Gln  Arg Gly Leu Asp Phe  Leu Asp Phe 
    2345                 2350                 2355             


Leu Asp  Asp Glu Leu Thr Tyr  Lys Thr Leu Phe Val  Pro Val Asn 
    2360                 2365                 2370             


Glu Gly  Phe Val Asp Asn Met  Thr Leu Ser Gly Pro  Asp Leu Glu 
    2375                 2380                 2385             


Leu His  Ala Ser Asn Ala Thr  Leu Leu Ser Ala Asn  Ala Ser Gln 
    2390                 2395                 2400             


Gly Lys  Leu Leu Pro Ala His  Ser Gly Leu Ser Leu  Ile Ile Ser 
    2405                 2410                 2415             


Asp Ala  Gly Pro Asp Asn Ser  Ser Trp Ala Pro Val  Ala Pro Gly 
    2420                 2425                 2430             


Thr Val  Val Val Ser Arg Ile  Ile Val Trp Asp Ile  Met Ala Phe 
    2435                 2440                 2445             


Asn Gly  Ile Ile His Ala Leu  Ala Ser Pro Leu Leu  Ala Pro Pro 
    2450                 2455                 2460             


Gln Pro  Gln Ala Val Leu Ala  Pro Glu Ala Pro Pro  Val Ala Ala 
    2465                 2470                 2475             


Gly Val  Gly Ala Val Leu Ala  Ala Gly Ala Leu Leu  Gly Leu Val 
    2480                 2485                 2490             


Ala Gly  Ala Leu Tyr Leu Arg  Ala Arg Gly Lys Pro  Met Gly Phe 
    2495                 2500                 2505             


Gly Phe  Ser Ala Phe Gln Ala  Glu Asp Asp Ala Asp  Asp Asp Phe 
    2510                 2515                 2520             


Ser Pro  Trp Gln Glu Gly Thr  Asn Pro Thr Leu Val  Ser Val Pro 
    2525                 2530                 2535             


Asn Pro  Val Phe Gly Ser Asp  Thr Phe Cys Glu Pro  Phe Asp Asp 
    2540                 2545                 2550             


Ser Leu  Leu Glu Glu Asp Phe  Pro Asp Thr Gln Arg  Ile Leu Thr 
    2555                 2560                 2565             


Val Lys  
    2570 


<210>  4040
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  4040

Met Ala Glu Val His Arg Arg Gln His Ala Arg Val Lys Gly Glu Ala 
1               5                   10                  15      


Pro Ala Lys Ser Ser Thr Leu Arg Asp Glu Glu Glu Leu Gly Met Ala 
            20                  25                  30          


Ser Ala Glu Thr Leu Thr Val Phe Leu Lys Leu Leu Ala Ala Gly Phe 
        35                  40                  45              


Tyr Gly Val Ser Ser Phe Leu Ile Val Val Val Asn Lys Ser Val Leu 
    50                  55                  60                  


Thr Asn Tyr Arg Phe Pro Ser Ser Leu Cys Val Gly Leu Gly Gln Met 
65                  70                  75                  80  


Val Ala Thr Val Ala Val Leu Trp Val Gly Lys Ala Leu Arg Val Val 
                85                  90                  95      


Lys Phe Pro Asp Leu Asp Arg Asn Val Pro Arg Lys Thr Phe Pro Leu 
            100                 105                 110         


Pro Leu Leu Tyr Phe Gly Asn Gln Ile Thr Gly Leu Phe Ser Thr Lys 
        115                 120                 125             


Lys Leu Asn Leu Pro Met Phe Thr Val Leu Arg Arg Phe Ser Ile Leu 
    130                 135                 140                 


Phe Thr Met Phe Ala Glu Gly Val Leu Leu Lys Lys Thr Phe Ser Trp 
145                 150                 155                 160 


Gly Ile Lys Met Thr Val Phe Ala Met Ile Ile Gly Ala Phe Val Ala 
                165                 170                 175     


Ala Ser Ser Asp Leu Ala Phe Asp Leu Glu Gly Tyr Ala Phe Ile Leu 
            180                 185                 190         


Ile Asn Asp Val Leu Thr Ala Ala Asn Gly Ala Tyr Val Lys Gln Lys 
        195                 200                 205             


Leu Asp Ser Lys Glu Leu Gly Lys Tyr Gly Leu Leu Tyr Tyr Asn Ala 
    210                 215                 220                 


Leu Phe Met Ile Leu Pro Thr Leu Ala Ile Ala Tyr Phe Thr Gly Asp 
225                 230                 235                 240 


Ala Gln Lys Ala Val Glu Phe Glu Gly Trp Ala Asp Thr Leu Phe Leu 
                245                 250                 255     


Leu Gln Phe Thr Leu Ser Cys Val Met Gly Phe Ile Leu Met Tyr Ala 
            260                 265                 270         


Thr Val Leu Cys Thr Gln Tyr Asn Ser Ala Leu Thr Thr Thr Ile Val 
        275                 280                 285             


Gly Cys Ile Lys Asn Ile Leu Ile Thr Tyr Ile Gly Met Val Phe Gly 
    290                 295                 300                 


Gly Asp Tyr Ile Phe Thr Trp Thr Asn Phe Ile Gly Leu Asn Ile Ser 
305                 310                 315                 320 


Ile Ala Gly Ser Leu Val Tyr Ser Tyr Ile Thr Phe Thr Glu Glu Gln 
                325                 330                 335     


Leu Ser Lys Gln Ser Glu Ala Asn Asn Lys Leu Asp Ile Lys Gly Lys 
            340                 345                 350         


Gly Ala Val 
        355 


<210>  4041
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  4041

Met Ala Glu Gly Asp Asn Arg Ser Thr Asn Leu Leu Ala Ala Glu Thr 
1               5                   10                  15      


Ala Ser Leu Glu Glu Gln Leu Gln Gly Trp Gly Glu Val Met Leu Met 
            20                  25                  30          


Ala Asp Lys Val Leu Arg Trp Glu Arg Ala Trp Phe Pro Pro Ala Ile 
        35                  40                  45              


Met Gly Val Val Ser Leu Val Phe Leu Ile Ile Tyr Tyr Leu Asp Pro 
    50                  55                  60                  


Ser Val Leu Ser Gly Val Ser Cys Phe Val Met Phe Leu Cys Leu Ala 
65                  70                  75                  80  


Asp Tyr Leu Val Pro Ile Leu Ala Pro Arg Ile Phe Gly Ser Asn Lys 
                85                  90                  95      


Trp Thr Thr Glu Gln Gln Gln Arg Phe His Glu Ile Cys Ser Asn Leu 
            100                 105                 110         


Val Lys Thr Arg Arg Arg Ala Val Gly Trp Trp Lys Arg Leu Phe Thr 
        115                 120                 125             


Leu Lys Glu Glu Lys Pro Lys Met Tyr Phe Met Thr Met Ile Val Ser 
    130                 135                 140                 


Leu Ala Ala Val Ala Trp Val Gly Gln Gln Val His Asn Leu Leu Leu 
145                 150                 155                 160 


Thr Tyr Leu Ile Val Thr Ser Leu Leu Leu Leu Pro Gly Leu Asn Gln 
                165                 170                 175     


His Gly Ile Ile Leu Lys Tyr Ile Gly Met Ala Lys Arg Glu Ile Asn 
            180                 185                 190         


Lys Leu Leu Lys Gln Lys Glu Lys Lys Asn Glu 
        195                 200             


<210>  4042
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  4042

Met Thr Gln Glu Pro Phe Arg Glu Glu Leu Ala Tyr Asp Arg Met Pro 
1               5                   10                  15      


Thr Leu Glu Arg Gly Arg Gln Asp Pro Ala Ser Tyr Ala Pro Asp Ala 
            20                  25                  30          


Lys Pro Ser Asp Leu Gln Leu Ser Lys Arg Leu Pro Pro Cys Phe Ser 
        35                  40                  45              


His Lys Thr Trp Val Phe Ser Val Leu Met Gly Ser Cys Leu Leu Val 
    50                  55                  60                  


Thr Ser Gly Phe Ser Leu Tyr Leu Gly Asn Val Phe Pro Ala Glu Met 
65                  70                  75                  80  


Asp Tyr Leu Arg Cys Ala Ala Gly Ser Cys Ile Pro Ser Ala Ile Val 
                85                  90                  95      


Ser Phe Thr Val Ser Arg Arg Asn Ala Asn Val Ile Pro Asn Phe Gln 
            100                 105                 110         


Ile Leu Phe Val Ser Thr Phe Ala Val Thr Thr Thr Cys Leu Ile Trp 
        115                 120                 125             


Phe Gly Cys Lys Leu Val Leu Asn Pro Ser Ala Ile Asn Ile Asn Phe 
    130                 135                 140                 


Asn Leu Ile Leu Leu Leu Leu Leu Glu Leu Leu Met Ala Ala Thr Val 
145                 150                 155                 160 


Ile Ile Ala Ala Arg Ser Ser Glu Glu Asp Cys Lys Lys Lys Lys Gly 
                165                 170                 175     


Ser Met Ser Asp Ser Ala Asn Ile Leu Asp Glu Val Pro Phe Pro Ala 
            180                 185                 190         


Arg Val Leu Lys Ser Tyr Ser Val Val Glu Val Ile Ala Gly Ile Ser 
        195                 200                 205             


Ala Val Leu Gly Gly Ile Ile Ala Leu Asn Val Asp Asp Ser Val Ser 
    210                 215                 220                 


Gly Pro His Leu Ser Val Thr Phe Phe Trp Ile Leu Val Ala Cys Phe 
225                 230                 235                 240 


Pro Ser Ala Ile Ala Ser His Val Ala Ala Glu Cys Pro Ser Lys Cys 
                245                 250                 255     


Leu Val Glu Val Leu Ile Ala Ile Ser Ser Leu Thr Ser Pro Leu Leu 
            260                 265                 270         


Phe Thr Ala Ser Gly Tyr Leu Ser Phe Ser Ile Met Arg Ile Val Glu 
        275                 280                 285             


Met Phe Lys Asp Tyr Pro Pro Ala Ile Lys Pro Ser Tyr Asp Val Leu 
    290                 295                 300                 


Leu Leu Leu Leu Leu Leu Val Leu Leu Leu Gln Ala Gly Leu Asn Thr 
305                 310                 315                 320 


Gly Thr Ala Ile Gln Cys Val Arg Phe Lys Val Ser Ala Arg Leu Gln 
                325                 330                 335     


Gly Ala Ser Trp Asp Thr Gln Asn Gly Pro Gln Glu Arg Leu Ala Gly 
            340                 345                 350         


Glu Val Ala Arg Ser Pro Leu Lys Glu Phe Asp Lys Glu Lys Ala Trp 
        355                 360                 365             


Arg Ala Val Val Val Gln Met Ala Gln 
    370                 375         


<210>  4043
<211>  1132
<212>  PRT
<213>  Homo sapiens

<400>  4043

Met Gln Arg Arg Gly Ala Gly Leu Gly Trp Pro Arg Gln Gln Gln Gln 
1               5                   10                  15      


Gln Pro Pro Pro Leu Ala Val Gly Pro Arg Ala Ala Ala Met Val Pro 
            20                  25                  30          


Ser Gly Gly Val Pro Gln Gly Leu Gly Gly Arg Ser Ala Cys Ala Leu 
        35                  40                  45              


Leu Leu Leu Cys Tyr Leu Asn Val Val Pro Ser Leu Gly Arg Gln Thr 
    50                  55                  60                  


Ser Leu Thr Thr Ser Val Ile Pro Lys Ala Glu Gln Ser Val Ala Tyr 
65                  70                  75                  80  


Lys Asp Phe Ile Tyr Phe Thr Val Phe Glu Gly Asn Val Arg Asn Val 
                85                  90                  95      


Ser Glu Val Ser Val Glu Tyr Leu Cys Ser Gln Pro Cys Val Val Asn 
            100                 105                 110         


Leu Glu Ala Val Val Ser Ser Glu Phe Arg Ser Ser Ile Pro Val Tyr 
        115                 120                 125             


Lys Lys Arg Trp Lys Asn Glu Lys His Leu His Thr Ser Arg Thr Gln 
    130                 135                 140                 


Ile Val His Val Lys Phe Pro Ser Ile Met Val Tyr Arg Asp Asp Tyr 
145                 150                 155                 160 


Phe Ile Arg His Ser Ile Ser Val Ser Ala Val Ile Val Arg Ala Trp 
                165                 170                 175     


Ile Thr His Lys Tyr Ser Gly Arg Asp Trp Asn Val Lys Trp Glu Glu 
            180                 185                 190         


Asn Leu Leu His Ala Val Ala Lys Asn Tyr Thr Leu Leu Gln Thr Ile 
        195                 200                 205             


Pro Pro Phe Glu Arg Pro Phe Lys Asp His Gln Val Cys Leu Glu Trp 
    210                 215                 220                 


Asn Met Gly Tyr Ile Trp Asn Leu Arg Ala Asn Arg Ile Pro Gln Cys 
225                 230                 235                 240 


Pro Leu Glu Asn Asp Val Val Ala Leu Leu Gly Phe Pro Tyr Ala Ser 
                245                 250                 255     


Ser Gly Glu Asn Thr Gly Ile Val Lys Lys Phe Pro Arg Phe Arg Asn 
            260                 265                 270         


Arg Glu Leu Glu Ala Thr Arg Arg Gln Arg Met Asp Tyr Pro Val Phe 
        275                 280                 285             


Thr Val Ser Leu Trp Leu Tyr Leu Leu His Tyr Cys Lys Ala Asn Leu 
    290                 295                 300                 


Cys Gly Ile Leu Tyr Phe Val Asp Ser Asn Glu Met Tyr Gly Thr Pro 
305                 310                 315                 320 


Ser Val Phe Leu Thr Glu Glu Gly Tyr Leu His Ile Gln Met His Leu 
                325                 330                 335     


Val Lys Gly Glu Asp Leu Ala Val Lys Thr Lys Phe Ile Ile Pro Leu 
            340                 345                 350         


Lys Glu Trp Phe Arg Leu Asp Ile Ser Phe Asn Gly Gly Gln Ile Val 
        355                 360                 365             


Val Thr Thr Ser Ile Gly Gln Asp Leu Lys Ser Tyr His Asn Gln Thr 
    370                 375                 380                 


Ile Ser Phe Arg Glu Asp Phe His Tyr Asn Asp Thr Ala Gly Tyr Phe 
385                 390                 395                 400 


Ile Ile Gly Gly Ser Arg Tyr Val Ala Gly Ile Glu Gly Phe Phe Gly 
                405                 410                 415     


Pro Leu Lys Tyr Tyr Arg Leu Arg Ser Leu His Pro Ala Gln Ile Phe 
            420                 425                 430         


Asn Pro Leu Leu Glu Lys Gln Leu Ala Glu Gln Ile Lys Leu Tyr Tyr 
        435                 440                 445             


Glu Arg Cys Ala Glu Val Gln Glu Ile Val Ser Val Tyr Ala Ser Ala 
    450                 455                 460                 


Ala Lys His Gly Gly Glu Arg Gln Glu Ala Cys His Leu His Asn Ser 
465                 470                 475                 480 


Tyr Leu Asp Leu Gln Arg Arg Tyr Gly Arg Pro Ser Met Cys Arg Ala 
                485                 490                 495     


Phe Pro Trp Glu Lys Glu Leu Lys Asp Lys His Pro Ser Leu Phe Gln 
            500                 505                 510         


Ala Leu Leu Glu Met Asp Leu Leu Thr Val Pro Arg Asn Gln Asn Glu 
        515                 520                 525             


Ser Val Ser Glu Ile Gly Gly Lys Ile Phe Glu Lys Ala Val Lys Arg 
    530                 535                 540                 


Leu Ser Ser Ile Asp Gly Leu His Gln Ile Ser Ser Ile Val Pro Phe 
545                 550                 555                 560 


Leu Thr Asp Ser Ser Cys Cys Gly Tyr His Lys Ala Ser Tyr Tyr Leu 
                565                 570                 575     


Ala Val Phe Tyr Glu Thr Gly Leu Asn Val Pro Arg Asp Gln Leu Gln 
            580                 585                 590         


Gly Met Leu Tyr Ser Leu Val Gly Gly Gln Gly Ser Glu Arg Leu Ser 
        595                 600                 605             


Ser Met Asn Leu Gly Tyr Lys His Tyr Gln Gly Ile Asp Asn Tyr Pro 
    610                 615                 620                 


Leu Asp Trp Glu Leu Ser Tyr Ala Tyr Tyr Ser Asn Ile Ala Thr Lys 
625                 630                 635                 640 


Thr Pro Leu Asp Gln His Thr Leu Gln Gly Asp Gln Ala Tyr Val Glu 
                645                 650                 655     


Thr Ile Arg Leu Lys Asp Asp Glu Ile Leu Lys Val Gln Thr Lys Glu 
            660                 665                 670         


Asp Gly Asp Val Phe Met Trp Leu Lys His Glu Ala Thr Arg Gly Asn 
        675                 680                 685             


Ala Ala Ala Gln Gln Arg Leu Ala Gln Met Leu Phe Trp Gly Gln Gln 
    690                 695                 700                 


Gly Val Ala Lys Asn Pro Glu Ala Ala Ile Glu Trp Tyr Ala Lys Gly 
705                 710                 715                 720 


Ala Leu Glu Thr Glu Asp Pro Ala Leu Ile Tyr Asp Tyr Ala Ile Val 
                725                 730                 735     


Leu Phe Lys Gly Gln Gly Val Lys Lys Asn Arg Arg Leu Ala Leu Glu 
            740                 745                 750         


Leu Met Lys Lys Ala Ala Ser Lys Gly Leu His Gln Ala Val Asn Gly 
        755                 760                 765             


Leu Gly Trp Tyr Tyr His Lys Phe Lys Lys Asn Tyr Ala Lys Ala Ala 
    770                 775                 780                 


Lys Tyr Trp Leu Lys Ala Glu Glu Met Gly Asn Pro Asp Ala Ser Tyr 
785                 790                 795                 800 


Asn Leu Gly Val Leu His Leu Asp Gly Ile Phe Pro Gly Val Pro Gly 
                805                 810                 815     


Arg Asn Gln Thr Leu Ala Gly Glu Tyr Phe His Lys Ala Ala Gln Gly 
            820                 825                 830         


Gly His Met Glu Gly Thr Leu Trp Cys Ser Leu Tyr Tyr Ile Thr Gly 
        835                 840                 845             


Asn Leu Glu Thr Phe Pro Arg Asp Pro Glu Lys Ala Val Val Trp Ala 
    850                 855                 860                 


Lys His Val Ala Glu Lys Asn Gly Tyr Leu Gly His Val Ile Arg Lys 
865                 870                 875                 880 


Gly Leu Asn Ala Tyr Leu Glu Gly Ser Trp His Glu Ala Leu Leu Tyr 
                885                 890                 895     


Tyr Val Leu Ala Ala Glu Thr Gly Ile Glu Val Ser Gln Thr Asn Leu 
            900                 905                 910         


Ala His Ile Cys Glu Glu Arg Pro Asp Leu Ala Arg Arg Tyr Leu Gly 
        915                 920                 925             


Val Asn Cys Val Trp Arg Tyr Tyr Asn Phe Ser Val Phe Gln Ile Asp 
    930                 935                 940                 


Ala Pro Ser Phe Ala Tyr Leu Lys Met Gly Asp Leu Tyr Tyr Tyr Gly 
945                 950                 955                 960 


His Gln Asn Gln Ser Gln Asp Leu Glu Leu Ser Val Gln Met Tyr Ala 
                965                 970                 975     


Gln Ala Ala Leu Asp Gly Asp Ser Gln Gly Phe Phe Asn Leu Ala Leu 
            980                 985                 990         


Leu Ile Glu Glu Gly Thr Ile Ile  Pro His His Ile Leu  Asp Phe Leu 
        995                 1000                 1005             


Glu Ile  Asp Ser Thr Leu His  Ser Asn Asn Ile Ser  Ile Leu Gln 
    1010                 1015                 1020             


Glu Leu  Tyr Glu Arg Cys Trp  Ser His Ser Asn Glu  Glu Ser Phe 
    1025                 1030                 1035             


Ser Pro  Cys Ser Leu Ala Trp  Leu Tyr Leu His Leu  Arg Leu Leu 
    1040                 1045                 1050             


Trp Gly  Ala Ile Leu His Ser  Ala Leu Ile Tyr Phe  Leu Gly Thr 
    1055                 1060                 1065             


Phe Leu  Leu Ser Ile Leu Ile  Ala Trp Thr Val Gln  Tyr Phe Gln 
    1070                 1075                 1080             


Ser Val  Ser Ala Ser Asp Pro  Pro Pro Arg Pro Ser  Gln Ala Ser 
    1085                 1090                 1095             


Pro Asp  Thr Ala Thr Ser Thr  Ala Ser Pro Ala Val  Thr Pro Ala 
    1100                 1105                 1110             


Ala Asp  Ala Ser Asp Gln Asp  Gln Pro Thr Val Thr  Asn Asn Pro 
    1115                 1120                 1125             


Glu Pro  Arg Gly 
    1130         


<210>  4044
<211>  1657
<212>  PRT
<213>  Homo sapiens

<400>  4044

Met Gly Leu Gln Ala Arg Arg Trp Ala Ser Gly Ser Arg Gly Ala Ala 
1               5                   10                  15      


Gly Pro Arg Arg Gly Val Leu Gln Leu Leu Pro Leu Pro Leu Pro Leu 
            20                  25                  30          


Pro Leu Leu Leu Leu Leu Leu Leu Arg Pro Gly Ala Gly Arg Ala Ala 
        35                  40                  45              


Ala Gln Gly Glu Ala Glu Ala Pro Thr Leu Tyr Leu Trp Lys Thr Gly 
    50                  55                  60                  


Pro Trp Gly Arg Cys Met Gly Asp Glu Cys Gly Pro Gly Gly Ile Gln 
65                  70                  75                  80  


Thr Arg Ala Val Trp Cys Ala His Val Glu Gly Trp Thr Thr Leu His 
                85                  90                  95      


Thr Asn Cys Lys Gln Ala Glu Arg Pro Asn Asn Gln Gln Asn Cys Phe 
            100                 105                 110         


Lys Val Cys Asp Trp His Lys Glu Leu Tyr Asp Trp Arg Leu Gly Pro 
        115                 120                 125             


Trp Asn Gln Cys Gln Pro Val Ile Ser Lys Ser Leu Glu Lys Pro Leu 
    130                 135                 140                 


Glu Cys Ile Lys Gly Glu Glu Gly Ile Gln Val Arg Glu Ile Ala Cys 
145                 150                 155                 160 


Ile Gln Lys Asp Lys Asp Ile Pro Ala Glu Asp Ile Ile Cys Glu Tyr 
                165                 170                 175     


Phe Glu Pro Lys Pro Leu Leu Glu Gln Ala Cys Leu Ile Pro Cys Gln 
            180                 185                 190         


Gln Asp Cys Ile Val Ser Glu Phe Ser Ala Trp Ser Glu Cys Ser Lys 
        195                 200                 205             


Thr Cys Gly Ser Gly Leu Gln His Arg Thr Arg His Val Val Ala Pro 
    210                 215                 220                 


Pro Gln Phe Gly Gly Ser Gly Cys Pro Asn Leu Thr Glu Phe Gln Val 
225                 230                 235                 240 


Cys Gln Ser Ser Pro Cys Glu Ala Glu Glu Leu Arg Tyr Ser Leu His 
                245                 250                 255     


Val Gly Pro Trp Ser Thr Cys Ser Met Pro His Ser Arg Gln Val Arg 
            260                 265                 270         


Gln Ala Arg Arg Arg Gly Lys Asn Lys Glu Arg Glu Lys Asp Arg Ser 
        275                 280                 285             


Lys Gly Val Lys Asp Pro Glu Ala Arg Glu Leu Ile Lys Lys Lys Arg 
    290                 295                 300                 


Asn Arg Asn Arg Gln Asn Arg Gln Glu Asn Lys Tyr Trp Asp Ile Gln 
305                 310                 315                 320 


Ile Gly Tyr Gln Thr Arg Glu Val Met Cys Ile Asn Lys Thr Gly Lys 
                325                 330                 335     


Ala Ala Asp Leu Ser Phe Cys Gln Gln Glu Lys Leu Pro Met Thr Phe 
            340                 345                 350         


Gln Ser Cys Val Ile Thr Lys Glu Cys Gln Val Ser Glu Trp Ser Glu 
        355                 360                 365             


Trp Ser Pro Cys Ser Lys Thr Cys His Asp Met Val Ser Pro Ala Gly 
    370                 375                 380                 


Thr Arg Val Arg Thr Arg Thr Ile Arg Gln Phe Pro Ile Gly Ser Glu 
385                 390                 395                 400 


Lys Glu Cys Pro Glu Phe Glu Glu Lys Glu Pro Cys Leu Ser Gln Gly 
                405                 410                 415     


Asp Gly Val Val Pro Cys Ala Thr Tyr Gly Trp Arg Thr Thr Glu Trp 
            420                 425                 430         


Thr Glu Cys Arg Val Asp Pro Leu Leu Ser Gln Gln Asp Lys Arg Arg 
        435                 440                 445             


Gly Asn Gln Thr Ala Leu Cys Gly Gly Gly Ile Gln Thr Arg Glu Val 
    450                 455                 460                 


Tyr Cys Val Gln Ala Asn Glu Asn Leu Leu Ser Gln Leu Ser Thr His 
465                 470                 475                 480 


Lys Asn Lys Glu Ala Ser Lys Pro Met Asp Leu Lys Leu Cys Thr Gly 
                485                 490                 495     


Pro Ile Pro Asn Thr Thr Gln Leu Cys His Ile Pro Cys Pro Thr Glu 
            500                 505                 510         


Cys Glu Val Ser Pro Trp Ser Ala Trp Gly Pro Cys Thr Tyr Glu Asn 
        515                 520                 525             


Cys Asn Asp Gln Gln Gly Lys Lys Gly Phe Lys Leu Arg Lys Arg Arg 
    530                 535                 540                 


Ile Thr Asn Glu Pro Thr Gly Gly Ser Gly Val Thr Gly Asn Cys Pro 
545                 550                 555                 560 


His Leu Leu Glu Ala Ile Pro Cys Glu Glu Pro Ala Cys Tyr Asp Trp 
                565                 570                 575     


Lys Ala Val Arg Leu Gly Asn Cys Glu Pro Asp Asn Gly Lys Glu Cys 
            580                 585                 590         


Gly Pro Gly Thr Gln Val Gln Glu Val Val Cys Ile Asn Ser Asp Gly 
        595                 600                 605             


Glu Glu Val Asp Arg Gln Leu Cys Arg Asp Ala Ile Phe Pro Ile Pro 
    610                 615                 620                 


Val Ala Cys Asp Ala Pro Cys Pro Lys Asp Cys Val Leu Ser Thr Trp 
625                 630                 635                 640 


Ser Thr Trp Ser Ser Cys Ser His Thr Cys Ser Gly Lys Thr Thr Glu 
                645                 650                 655     


Gly Lys Gln Ile Arg Ala Arg Ser Ile Leu Ala Tyr Ala Gly Glu Glu 
            660                 665                 670         


Gly Gly Ile Arg Cys Pro Asn Ser Ser Ala Leu Gln Glu Val Arg Ser 
        675                 680                 685             


Cys Asn Glu His Pro Cys Thr Val Tyr His Trp Gln Thr Gly Pro Trp 
    690                 695                 700                 


Gly Gln Cys Ile Glu Asp Thr Ser Val Ser Ser Phe Asn Thr Thr Thr 
705                 710                 715                 720 


Thr Trp Asn Gly Glu Ala Ser Cys Ser Val Gly Met Gln Thr Arg Lys 
                725                 730                 735     


Val Ile Cys Val Arg Val Asn Val Gly Gln Val Gly Pro Lys Lys Cys 
            740                 745                 750         


Pro Glu Ser Leu Arg Pro Glu Thr Val Arg Pro Cys Leu Leu Pro Cys 
        755                 760                 765             


Lys Lys Asp Cys Ile Val Thr Pro Tyr Ser Asp Trp Thr Ser Cys Pro 
    770                 775                 780                 


Ser Ser Cys Lys Glu Gly Asp Ser Ser Ile Arg Lys Gln Ser Arg His 
785                 790                 795                 800 


Arg Val Ile Ile Gln Leu Pro Ala Asn Gly Gly Arg Asp Cys Thr Asp 
                805                 810                 815     


Pro Leu Tyr Glu Glu Lys Ala Cys Glu Ala Pro Gln Ala Cys Gln Ser 
            820                 825                 830         


Tyr Arg Trp Lys Thr His Lys Trp Arg Arg Cys Gln Leu Val Pro Trp 
        835                 840                 845             


Ser Val Gln Gln Asp Ser Pro Gly Ala Gln Glu Gly Cys Gly Pro Gly 
    850                 855                 860                 


Arg Gln Ala Arg Ala Ile Thr Cys Arg Lys Gln Asp Gly Gly Gln Ala 
865                 870                 875                 880 


Gly Ile His Glu Cys Leu Gln Tyr Ala Gly Pro Val Pro Ala Leu Thr 
                885                 890                 895     


Gln Ala Cys Gln Ile Pro Cys Gln Asp Asp Cys Gln Leu Thr Ser Trp 
            900                 905                 910         


Ser Lys Phe Ser Ser Cys Asn Gly Asp Cys Gly Ala Val Arg Thr Arg 
        915                 920                 925             


Lys Arg Thr Leu Val Gly Lys Ser Lys Lys Lys Glu Lys Cys Lys Asn 
    930                 935                 940                 


Ser His Leu Tyr Pro Leu Ile Glu Thr Gln Tyr Cys Pro Cys Asp Lys 
945                 950                 955                 960 


Tyr Asn Ala Gln Pro Val Gly Asn Trp Ser Asp Cys Ile Leu Pro Glu 
                965                 970                 975     


Gly Lys Val Glu Val Leu Leu Gly Met Lys Val Gln Gly Asp Ile Lys 
            980                 985                 990         


Glu Cys Gly Gln Gly Tyr Arg Tyr  Gln Ala Met Ala Cys  Tyr Asp Gln 
        995                 1000                 1005             


Asn Gly  Arg Leu Val Glu Thr  Ser Arg Cys Asn Ser  His Gly Tyr 
    1010                 1015                 1020             


Ile Glu  Glu Ala Cys Ile Ile  Pro Cys Pro Ser Asp  Cys Lys Leu 
    1025                 1030                 1035             


Ser Glu  Trp Ser Asn Trp Ser  Arg Cys Ser Lys Ser  Cys Gly Ser 
    1040                 1045                 1050             


Gly Val  Lys Val Arg Ser Lys  Trp Leu Arg Glu Lys  Pro Tyr Asn 
    1055                 1060                 1065             


Gly Gly  Arg Pro Cys Pro Lys  Leu Asp His Val Asn  Gln Ala Gln 
    1070                 1075                 1080             


Val Tyr  Glu Val Val Pro Cys  His Ser Asp Cys Asn  Gln Tyr Leu 
    1085                 1090                 1095             


Trp Val  Thr Glu Pro Trp Ser  Ile Cys Lys Val Thr  Phe Val Asn 
    1100                 1105                 1110             


Met Arg  Glu Asn Cys Gly Glu  Gly Val Gln Thr Arg  Lys Val Arg 
    1115                 1120                 1125             


Cys Met  Gln Asn Thr Ala Asp  Gly Pro Ser Glu His  Val Glu Asp 
    1130                 1135                 1140             


Tyr Leu  Cys Asp Pro Glu Glu  Met Pro Leu Gly Ser  Arg Val Cys 
    1145                 1150                 1155             


Lys Leu  Pro Cys Pro Glu Asp  Cys Val Ile Ser Glu  Trp Gly Pro 
    1160                 1165                 1170             


Trp Thr  Gln Cys Val Leu Pro  Cys Asn Gln Ser Ser  Phe Arg Gln 
    1175                 1180                 1185             


Arg Ser  Ala Asp Pro Ile Arg  Gln Pro Ala Asp Glu  Gly Arg Ser 
    1190                 1195                 1200             


Cys Pro  Asn Ala Val Glu Lys  Glu Pro Cys Asn Leu  Asn Lys Asn 
    1205                 1210                 1215             


Cys Tyr  His Tyr Asp Tyr Asn  Val Thr Asp Trp Ser  Thr Cys Gln 
    1220                 1225                 1230             


Leu Ser  Glu Lys Ala Val Cys  Gly Asn Gly Ile Lys  Thr Arg Met 
    1235                 1240                 1245             


Leu Asp  Cys Val Arg Ser Asp  Gly Lys Ser Val Asp  Leu Lys Tyr 
    1250                 1255                 1260             


Cys Glu  Ala Leu Gly Leu Glu  Lys Asn Trp Gln Met  Asn Thr Ser 
    1265                 1270                 1275             


Cys Met  Val Glu Cys Pro Val  Asn Cys Gln Leu Ser  Asp Trp Ser 
    1280                 1285                 1290             


Pro Trp  Ser Glu Cys Ser Gln  Thr Cys Gly Leu Thr  Gly Lys Met 
    1295                 1300                 1305             


Ile Arg  Arg Arg Thr Val Thr  Gln Pro Phe Gln Gly  Asp Gly Arg 
    1310                 1315                 1320             


Pro Cys  Pro Ser Leu Met Asp  Gln Ser Lys Pro Cys  Pro Val Lys 
    1325                 1330                 1335             


Pro Cys  Tyr Arg Trp Gln Tyr  Gly Gln Trp Ser Pro  Cys Gln Val 
    1340                 1345                 1350             


Gln Glu  Ala Gln Cys Gly Glu  Gly Thr Arg Thr Arg  Asn Ile Ser 
    1355                 1360                 1365             


Cys Val  Val Ser Asp Gly Ser  Ala Asp Asp Phe Ser  Lys Val Val 
    1370                 1375                 1380             


Asp Glu  Glu Phe Cys Ala Asp  Ile Glu Leu Ile Ile  Asp Gly Asn 
    1385                 1390                 1395             


Lys Asn  Met Val Leu Glu Glu  Ser Cys Ser Gln Pro  Cys Pro Gly 
    1400                 1405                 1410             


Asp Cys  Tyr Leu Lys Asp Trp  Ser Ser Trp Ser Leu  Cys Gln Leu 
    1415                 1420                 1425             


Thr Cys  Val Asn Gly Glu Asp  Leu Gly Phe Gly Gly  Ile Gln Val 
    1430                 1435                 1440             


Arg Ser  Arg Pro Val Ile Ile  Gln Glu Leu Glu Asn  Gln His Leu 
    1445                 1450                 1455             


Cys Pro  Glu Gln Met Leu Glu  Thr Lys Ser Cys Tyr  Asp Gly Gln 
    1460                 1465                 1470             


Cys Tyr  Glu Tyr Lys Trp Met  Ala Ser Ala Trp Lys  Gly Ser Ser 
    1475                 1480                 1485             


Arg Thr  Val Trp Cys Gln Arg  Ser Asp Gly Ile Asn  Val Thr Gly 
    1490                 1495                 1500             


Gly Cys  Leu Val Met Ser Gln  Pro Asp Ala Asp Arg  Ser Cys Asn 
    1505                 1510                 1515             


Pro Pro  Cys Ser Gln Pro His  Ser Tyr Cys Ser Glu  Thr Lys Thr 
    1520                 1525                 1530             


Cys His  Cys Glu Glu Gly Tyr  Thr Glu Val Met Ser  Ser Asn Ser 
    1535                 1540                 1545             


Thr Leu  Glu Gln Cys Thr Leu  Ile Pro Val Val Val  Leu Pro Thr 
    1550                 1555                 1560             


Met Glu  Asp Lys Arg Gly Asp  Val Lys Thr Ser Arg  Ala Val His 
    1565                 1570                 1575             


Pro Thr  Gln Pro Ser Ser Asn  Pro Ala Gly Arg Gly  Arg Thr Trp 
    1580                 1585                 1590             


Phe Leu  Gln Pro Phe Gly Pro  Asp Gly Arg Leu Lys  Thr Trp Val 
    1595                 1600                 1605             


Tyr Gly  Val Ala Ala Gly Ala  Phe Val Leu Leu Ile  Phe Ile Val 
    1610                 1615                 1620             


Ser Met  Ile Tyr Leu Ala Cys  Lys Lys Pro Lys Lys  Pro Gln Arg 
    1625                 1630                 1635             


Arg Gln  Asn Asn Arg Leu Lys  Pro Leu Thr Leu Ala  Tyr Asp Gly 
    1640                 1645                 1650             


Asp Ala  Asp Met 
    1655         


<210>  4045
<211>  1134
<212>  PRT
<213>  Homo sapiens

<400>  4045

Met Asp Cys Ser Leu Val Arg Thr Leu Val His Arg Tyr Cys Ala Gly 
1               5                   10                  15      


Glu Glu Asn Trp Val Asp Ser Arg Thr Ile Tyr Val Gly His Arg Glu 
            20                  25                  30          


Pro Pro Pro Gly Ala Glu Ala Tyr Ile Pro Gln Arg Tyr Pro Asp Asn 
        35                  40                  45              


Arg Ile Val Ser Ser Lys Tyr Thr Phe Trp Asn Phe Ile Pro Lys Asn 
    50                  55                  60                  


Leu Phe Glu Gln Phe Arg Arg Val Ala Asn Phe Tyr Phe Leu Ile Ile 
65                  70                  75                  80  


Phe Leu Val Gln Leu Ile Ile Asp Thr Pro Thr Ser Pro Val Thr Ser 
                85                  90                  95      


Gly Leu Pro Leu Phe Phe Val Ile Thr Val Thr Ala Ile Lys Gln Gly 
            100                 105                 110         


Tyr Glu Asp Trp Leu Arg His Lys Ala Asp Asn Ala Met Asn Gln Cys 
        115                 120                 125             


Pro Val His Phe Ile Gln His Gly Lys Leu Val Arg Lys Gln Ser Arg 
    130                 135                 140                 


Lys Leu Arg Val Gly Asp Ile Val Met Val Lys Glu Asp Glu Thr Phe 
145                 150                 155                 160 


Pro Cys Asp Leu Ile Phe Leu Ser Ser Asn Arg Gly Asp Gly Thr Cys 
                165                 170                 175     


His Val Thr Thr Ala Ser Leu Asp Gly Glu Ser Ser His Lys Thr His 
            180                 185                 190         


Tyr Ala Val Gln Asp Thr Lys Gly Phe His Thr Glu Glu Asp Ile Gly 
        195                 200                 205             


Gly Leu His Ala Thr Ile Glu Cys Glu Gln Pro Gln Pro Asp Leu Tyr 
    210                 215                 220                 


Lys Phe Val Gly Arg Ile Asn Val Tyr Ser Asp Leu Asn Asp Pro Val 
225                 230                 235                 240 


Val Arg Pro Leu Gly Ser Glu Asn Leu Leu Leu Arg Gly Ala Thr Leu 
                245                 250                 255     


Lys Asn Thr Glu Lys Ile Phe Gly Val Ala Ile Tyr Thr Gly Met Glu 
            260                 265                 270         


Thr Lys Met Ala Leu Asn Tyr Gln Ser Lys Ser Gln Lys Arg Ser Ala 
        275                 280                 285             


Val Glu Lys Ser Met Asn Ala Phe Leu Ile Val Tyr Leu Cys Ile Leu 
    290                 295                 300                 


Ile Ser Lys Ala Leu Ile Asn Thr Val Leu Lys Tyr Met Trp Gln Ser 
305                 310                 315                 320 


Glu Pro Phe Arg Asp Glu Pro Trp Tyr Asn Gln Lys Thr Glu Ser Glu 
                325                 330                 335     


Arg Gln Arg Asn Leu Phe Leu Lys Ala Phe Thr Asp Phe Leu Ala Phe 
            340                 345                 350         


Met Val Leu Phe Asn Tyr Ile Ile Pro Val Ser Met Tyr Val Thr Val 
        355                 360                 365             


Glu Met Gln Lys Phe Leu Gly Ser Tyr Phe Ile Thr Trp Asp Glu Asp 
    370                 375                 380                 


Met Phe Asp Glu Glu Thr Gly Glu Gly Pro Leu Val Asn Thr Ser Asp 
385                 390                 395                 400 


Leu Asn Glu Glu Leu Gly Gln Val Glu Tyr Ile Phe Thr Asp Lys Thr 
                405                 410                 415     


Gly Thr Leu Thr Glu Asn Asn Met Glu Phe Lys Glu Cys Cys Ile Glu 
            420                 425                 430         


Gly His Val Tyr Val Pro His Val Ile Cys Asn Gly Gln Val Leu Pro 
        435                 440                 445             


Glu Ser Ser Gly Ile Asp Met Ile Asp Ser Ser Pro Ser Val Asn Gly 
    450                 455                 460                 


Arg Glu Arg Glu Glu Leu Phe Phe Arg Ala Leu Cys Leu Cys His Thr 
465                 470                 475                 480 


Val Gln Val Lys Asp Asp Asp Ser Val Asp Gly Pro Arg Lys Ser Pro 
                485                 490                 495     


Asp Gly Gly Lys Ser Cys Val Tyr Ile Ser Ser Ser Pro Asp Glu Val 
            500                 505                 510         


Ala Leu Val Glu Gly Val Gln Arg Leu Gly Phe Thr Tyr Leu Arg Leu 
        515                 520                 525             


Lys Asp Asn Tyr Met Glu Ile Leu Asn Arg Glu Asn His Ile Glu Arg 
    530                 535                 540                 


Phe Glu Leu Leu Glu Ile Leu Ser Phe Asp Ser Val Arg Arg Arg Met 
545                 550                 555                 560 


Ser Val Ile Val Lys Ser Ala Thr Gly Glu Ile Tyr Leu Phe Cys Lys 
                565                 570                 575     


Gly Ala Asp Ser Ser Ile Phe Pro Arg Val Ile Glu Gly Lys Val Asp 
            580                 585                 590         


Gln Ile Arg Ala Arg Val Glu Arg Asn Ala Val Glu Gly Leu Arg Thr 
        595                 600                 605             


Leu Cys Val Ala Tyr Lys Arg Leu Ile Gln Glu Glu Tyr Glu Gly Ile 
    610                 615                 620                 


Cys Lys Leu Leu Gln Ala Ala Lys Val Ala Leu Gln Asp Arg Glu Lys 
625                 630                 635                 640 


Lys Leu Ala Glu Ala Tyr Glu Gln Ile Glu Lys Asp Leu Thr Leu Leu 
                645                 650                 655     


Gly Ala Thr Ala Val Glu Asp Arg Leu Gln Glu Lys Ala Ala Asp Thr 
            660                 665                 670         


Ile Glu Ala Leu Gln Lys Ala Gly Ile Lys Val Trp Val Leu Thr Gly 
        675                 680                 685             


Asp Lys Met Glu Thr Ala Ala Ala Thr Cys Tyr Ala Cys Lys Leu Phe 
    690                 695                 700                 


Arg Arg Asn Thr Gln Leu Leu Glu Leu Thr Thr Lys Arg Ile Glu Glu 
705                 710                 715                 720 


Gln Ser Leu His Asp Val Leu Phe Glu Leu Ser Lys Thr Val Leu Arg 
                725                 730                 735     


His Ser Gly Ser Leu Thr Arg Asp Asn Leu Ser Gly Leu Ser Ala Asp 
            740                 745                 750         


Met Gln Asp Tyr Gly Leu Ile Ile Asp Gly Ala Ala Leu Ser Leu Ile 
        755                 760                 765             


Met Lys Pro Arg Glu Asp Gly Ser Ser Gly Asn Tyr Arg Glu Leu Phe 
    770                 775                 780                 


Leu Glu Ile Cys Arg Ser Cys Ser Ala Val Leu Cys Cys Arg Met Ala 
785                 790                 795                 800 


Pro Leu Gln Lys Ala Gln Ile Val Lys Leu Ile Lys Phe Ser Lys Glu 
                805                 810                 815     


His Pro Ile Thr Leu Ala Ile Gly Asp Gly Ala Asn Asp Val Ser Met 
            820                 825                 830         


Ile Leu Glu Ala His Val Gly Ile Gly Val Ile Gly Lys Glu Gly Arg 
        835                 840                 845             


Gln Ala Ala Arg Asn Ser Asp Tyr Ala Ile Pro Lys Phe Lys His Leu 
    850                 855                 860                 


Lys Lys Met Leu Leu Val His Gly His Phe Tyr Tyr Ile Arg Ile Ser 
865                 870                 875                 880 


Glu Leu Val Gln Tyr Phe Phe Tyr Lys Asn Val Cys Phe Ile Phe Pro 
                885                 890                 895     


Gln Phe Leu Tyr Gln Phe Phe Cys Gly Phe Ser Gln Gln Thr Leu Tyr 
            900                 905                 910         


Asp Thr Ala Tyr Leu Thr Leu Tyr Asn Ile Ser Phe Thr Ser Leu Pro 
        915                 920                 925             


Ile Leu Leu Tyr Ser Leu Met Glu Gln His Val Gly Ile Asp Val Leu 
    930                 935                 940                 


Lys Arg Asp Pro Thr Leu Tyr Arg Asp Val Ala Lys Asn Ala Leu Leu 
945                 950                 955                 960 


Arg Trp Arg Val Phe Ile Tyr Trp Thr Leu Leu Gly Leu Phe Asp Ala 
                965                 970                 975     


Leu Val Phe Phe Phe Gly Ala Tyr Phe Val Phe Glu Asn Thr Thr Val 
            980                 985                 990         


Thr Ser Asn Gly Gln Ile Phe Gly  Asn Trp Thr Phe Gly  Thr Leu Val 
        995                 1000                 1005             


Phe Thr  Val Met Val Phe Thr  Val Thr Leu Lys Leu  Ala Leu Asp 
    1010                 1015                 1020             


Thr His  Tyr Trp Thr Trp Ile  Asn His Phe Val Ile  Trp Gly Ser 
    1025                 1030                 1035             


Leu Leu  Phe Tyr Val Val Phe  Ser Leu Leu Trp Gly  Gly Val Ile 
    1040                 1045                 1050             


Trp Pro  Phe Leu Asn Tyr Gln  Arg Met Tyr Tyr Val  Phe Ile Gln 
    1055                 1060                 1065             


Met Leu  Ser Ser Gly Pro Ala  Trp Leu Ala Ile Val  Leu Leu Val 
    1070                 1075                 1080             


Thr Ile  Ser Leu Leu Pro Asp  Val Leu Lys Lys Val  Leu Cys Arg 
    1085                 1090                 1095             


Gln Leu  Trp Pro Thr Ala Thr  Glu Arg Val Gln Thr  Lys Ser Gln 
    1100                 1105                 1110             


Cys Leu  Ser Val Glu Gln Ser  Thr Ile Phe Met Leu  Ser Gln Thr 
    1115                 1120                 1125             


Ser Ser  Ser Leu Ser Phe 
    1130                 


<210>  4046
<211>  916
<212>  PRT
<213>  Homo sapiens

<400>  4046

Met Glu Thr Ser Gln Glu Thr Ser Leu Phe Leu Val Lys Ile Leu Glu 
1               5                   10                  15      


Glu Leu Asp Ser Lys Gln Asn Thr Val Ser Tyr Gln Asp Leu Cys Lys 
            20                  25                  30          


Ser Leu Cys Ala Arg Phe Asp Leu Ser Gln Leu Ala Lys Leu Arg Ser 
        35                  40                  45              


Val Leu Phe Tyr Thr Ala Cys Leu Asp Pro Asn Phe Pro Ala Thr Leu 
    50                  55                  60                  


Phe Lys Asp Lys Met Lys Cys Thr Val Asn Asn Gln Gln Ser Lys Lys 
65                  70                  75                  80  


Ile Met Val Ala Ala Asp Ile Val Thr Ile Phe Asn Leu Ile Gln Met 
                85                  90                  95      


Asn Gly Gly Ala Ala Lys Glu Lys Leu Pro Thr Gly Arg Gln Lys Val 
            100                 105                 110         


Arg Lys Lys Glu Ala Ser Phe Glu Ser Cys Arg Ser Asp Thr Glu Ile 
        115                 120                 125             


Cys Asn Ala Ala Glu Cys Glu Pro Leu Asn Cys Glu Leu Ser Glu Arg 
    130                 135                 140                 


Ser Phe Ser Arg Gly Tyr Pro Ile Arg Gln Ser Ser Lys Cys Arg Lys 
145                 150                 155                 160 


Met Asp Cys Lys Asp Cys Pro Gln Phe Val Pro Ala Ser Glu Pro Asn 
                165                 170                 175     


Phe Leu Leu Gly Val Ser Lys Glu Val Lys Asn Arg Ala Ala Ser Leu 
            180                 185                 190         


Asp Arg Leu Gln Ala Leu Ala Pro Tyr Ser Val Thr Ser Pro Gln Pro 
        195                 200                 205             


Cys Glu Met Gln Arg Thr Tyr Phe Pro Met Asn Ile Glu Asn Glu Ser 
    210                 215                 220                 


Ile Ser Asp Gln Asp Ser Leu Pro Ile Asn Gln Ser Ile Lys Glu Thr 
225                 230                 235                 240 


Phe Ile Ser Asn Glu Glu Pro Phe Val Val Gln Ser Cys Val Gln Lys 
                245                 250                 255     


Arg Asn Ile Phe Lys Glu Asp Phe His Asn Leu Met Ala Val Ser Pro 
            260                 265                 270         


Ser Leu Val Gly Pro Ile Ser Lys Ala Glu Asn Glu His Arg Glu Pro 
        275                 280                 285             


Gln Ser Arg Lys Glu Pro His Lys Pro Pro Phe Phe Asn His Ser Phe 
    290                 295                 300                 


Glu Met Pro Tyr Asn Ser Gln Tyr Leu Asn Pro Val Tyr Ser Pro Val 
305                 310                 315                 320 


Pro Asp Lys Arg Arg Ala Lys His Glu Ser Leu Asp Asp Leu Gln Ala 
                325                 330                 335     


Ser Thr Tyr Phe Gly Pro Thr Pro Val Met Gly Thr Gln Glu Ala Arg 
            340                 345                 350         


Arg Cys Leu Gly Lys Pro Asn Lys Gln Thr Pro Trp Pro Ala Lys Ser 
        355                 360                 365             


Trp Ser Leu Asn Thr Glu Glu Val Pro Asp Phe Glu Arg Ser Phe Phe 
    370                 375                 380                 


Asn Arg Asn Pro Ser Glu Glu Lys Leu His Tyr Pro Asn Ala Ser Ser 
385                 390                 395                 400 


Gln Thr Pro Asn Phe Pro Ala Pro Glu Arg Arg Pro Thr Tyr Leu Val 
                405                 410                 415     


Pro Lys Asp Gln Gln Pro Ile Leu Pro Ile Ala Tyr Ala Ala Lys Gln 
            420                 425                 430         


Asn Gly Leu Lys Ser Lys Glu Ile Ser Ser Pro Val Asp Leu Glu Lys 
        435                 440                 445             


His Glu Pro Val Lys Lys Phe Lys Asp Lys Ser Ile Asn Cys Thr Ser 
    450                 455                 460                 


Gly Gln Leu Ser Ser Asp Thr Ser Ser Val Gly Thr Gln Thr Glu His 
465                 470                 475                 480 


Val Leu Glu Pro Lys Lys Cys Arg Asp Leu Cys Thr Ser Gly Gln Gly 
                485                 490                 495     


Lys Tyr Ser Asp Arg His Thr Met Lys His Ser Asp Asp Asp Ser Glu 
            500                 505                 510         


Ile Val Ser Asp Asp Ile Ser Asp Ile Phe Arg Phe Leu Asp Asp Met 
        515                 520                 525             


Ser Ile Ser Gly Ser Thr Gly Val Ile Gln Ser Ser Cys Tyr Asn Ser 
    530                 535                 540                 


Thr Gly Ser Leu Ser Gln Leu His Lys Ser Asp Cys Asp Ser Ser Pro 
545                 550                 555                 560 


Glu His Asn Leu Thr Lys Ile Ala Asn Gly Val Pro Asn Ser Lys Gly 
                565                 570                 575     


Asp Lys Gly Asn Arg Pro Glu Asn Thr His His Ser Glu Glu Glu Leu 
            580                 585                 590         


Lys Thr Ser Val Cys Lys Leu Val Leu Arg Ile Gly Glu Ile Glu Arg 
        595                 600                 605             


Lys Leu Glu Ser Leu Ser Gly Val Arg Asp Glu Ile Ser Gln Val Leu 
    610                 615                 620                 


Gly Lys Leu Asn Lys Leu Asp Gln Lys Met Gln Gln Pro Glu Lys Val 
625                 630                 635                 640 


Ser Val Gln Ile Asp Leu Asn Ser Leu Thr Ser Glu Gly Pro Ser Asp 
                645                 650                 655     


Asp Ser Ala Ser Pro Arg Met Phe His Ala His Ser Gly Ser His Gly 
            660                 665                 670         


Pro Lys Leu Glu Asn Asn Pro Asp Trp Cys Cys Ser Asp Ala Ser Gly 
        675                 680                 685             


Ser Asn Ser Glu Ser Leu Arg Val Lys Ala Leu Lys Lys Ser Leu Phe 
    690                 695                 700                 


Thr Arg Pro Ser Ser Arg Ser Leu Thr Glu Glu Asn Ser Ala Thr Glu 
705                 710                 715                 720 


Ser Lys Ile Ala Ser Ile Ser Asn Ser Pro Arg Asp Trp Arg Thr Ile 
                725                 730                 735     


Thr Tyr Thr Asn Arg Val Gly Leu Asn Glu Glu Glu Ile Lys Asp Thr 
            740                 745                 750         


Gly Pro Gly Asp Asn Lys Asp Trp His Arg Lys Ser Lys Glu Ala Asp 
        755                 760                 765             


Arg Gln Tyr Asp Ile Pro Pro Gln His Arg Leu Pro Lys Gln Pro Lys 
    770                 775                 780                 


Asp Gly Phe Leu Val Glu Gln Val Phe Ser Pro His Pro Tyr Pro Ala 
785                 790                 795                 800 


Ser Leu Lys Ala His Met Lys Ser Asn Pro Leu Tyr Thr Asp Met Arg 
                805                 810                 815     


Leu Thr Glu Leu Ala Glu Val Lys Arg Gly Gln Pro Ser Trp Thr Ile 
            820                 825                 830         


Glu Glu Tyr Ala Arg Asn Ala Gly Asp Lys Gly Lys Leu Thr Ala Leu 
        835                 840                 845             


Asp Leu Gln Thr Gln Glu Ser Leu Asn Pro Asn Asn Leu Glu Tyr Trp 
    850                 855                 860                 


Met Glu Asp Ile Tyr Thr Pro Gly Tyr Asp Ser Leu Leu Lys Arg Lys 
865                 870                 875                 880 


Glu Ala Glu Phe Arg Arg Ala Lys Val Cys Lys Ile Ala Ala Leu Ile 
                885                 890                 895     


Ala Ala Ala Ala Cys Thr Val Ile Leu Val Ile Val Val Pro Ile Cys 
            900                 905                 910         


Thr Met Lys Ser 
        915     


<210>  4047
<211>  1287
<212>  PRT
<213>  Homo sapiens

<400>  4047

Met Ser Gly Gly Gly Gly Gly Gly Gly Ser Ala Pro Ser Arg Phe Ala 
1               5                   10                  15      


Asp Tyr Phe Val Ile Cys Gly Leu Asp Thr Glu Thr Gly Leu Glu Pro 
            20                  25                  30          


Asp Glu Leu Ser Ala Leu Cys Gln Tyr Ile Gln Ala Ser Lys Ala Arg 
        35                  40                  45              


Asp Gly Ala Ser Pro Phe Ile Ser Ser Thr Thr Glu Gly Glu Asn Phe 
    50                  55                  60                  


Glu Gln Thr Pro Leu Arg Arg Thr Phe Lys Ser Lys Val Leu Ala Arg 
65                  70                  75                  80  


Tyr Pro Glu Asn Val Glu Trp Asn Pro Phe Asp Gln Asp Ala Val Gly 
                85                  90                  95      


Met Leu Cys Met Pro Lys Gly Leu Ala Phe Lys Thr Gln Ala Asp Pro 
            100                 105                 110         


Arg Glu Pro Gln Phe His Ala Phe Ile Ile Thr Arg Glu Asp Gly Ser 
        115                 120                 125             


Arg Thr Phe Gly Phe Ala Leu Thr Phe Tyr Glu Glu Val Thr Ser Lys 
    130                 135                 140                 


Gln Ile Cys Ser Ala Met Gln Thr Leu Tyr His Met His Asn Ala Glu 
145                 150                 155                 160 


Tyr Asp Val Leu His Ala Pro Pro Ala Asp Asp Arg Asp Gln Ser Ser 
                165                 170                 175     


Met Glu Asp Gly Glu Asp Thr Pro Val Thr Lys Leu Gln Arg Phe Asn 
            180                 185                 190         


Ser Tyr Asp Ile Ser Arg Asp Thr Leu Tyr Val Ser Lys Cys Ile Cys 
        195                 200                 205             


Leu Ile Thr Pro Met Ser Phe Met Lys Ala Cys Arg Ser Val Leu Glu 
    210                 215                 220                 


Gln Leu His Gln Ala Val Thr Ser Pro Gln Pro Pro Pro Leu Pro Leu 
225                 230                 235                 240 


Glu Ser Tyr Ile Tyr Asn Val Leu Tyr Glu Val Pro Leu Pro Pro Pro 
                245                 250                 255     


Gly Arg Ser Leu Lys Phe Ser Gly Val Tyr Gly Pro Ile Ile Cys Gln 
            260                 265                 270         


Arg Pro Ser Thr Asn Glu Leu Pro Leu Phe Asp Phe Pro Val Lys Glu 
        275                 280                 285             


Val Phe Glu Leu Leu Gly Val Glu Asn Val Phe Gln Leu Phe Thr Cys 
    290                 295                 300                 


Ala Leu Leu Glu Phe Gln Ile Leu Leu Tyr Ser Gln His Tyr Gln Arg 
305                 310                 315                 320 


Leu Met Thr Val Ala Glu Thr Ile Thr Ala Leu Met Phe Pro Phe Gln 
                325                 330                 335     


Trp Gln His Val Tyr Val Pro Ile Leu Pro Ala Ser Leu Leu His Phe 
            340                 345                 350         


Leu Asp Ala Pro Val Pro Tyr Leu Met Gly Leu His Ser Asn Gly Leu 
        355                 360                 365             


Asp Asp Arg Ser Lys Leu Glu Leu Pro Gln Glu Ala Asn Leu Cys Phe 
    370                 375                 380                 


Val Asp Ile Asp Asn His Phe Ile Glu Leu Pro Glu Asp Leu Pro Gln 
385                 390                 395                 400 


Phe Pro Asn Lys Leu Glu Phe Val Gln Glu Val Ser Glu Ile Leu Met 
                405                 410                 415     


Ala Phe Gly Ile Pro Pro Glu Gly Asn Leu His Cys Ser Glu Ser Ala 
            420                 425                 430         


Ser Lys Leu Lys Arg Leu Arg Ala Ser Glu Leu Val Ser Asp Lys Arg 
        435                 440                 445             


Asn Gly Asn Ile Ala Gly Ser Pro Leu His Ser Tyr Glu Leu Leu Lys 
    450                 455                 460                 


Glu Asn Glu Thr Ile Ala Arg Leu Gln Ala Leu Val Lys Arg Thr Gly 
465                 470                 475                 480 


Val Ser Leu Glu Lys Leu Glu Val Arg Glu Asp Pro Ser Ser Asn Lys 
                485                 490                 495     


Asp Leu Lys Val Gln Cys Asp Glu Glu Glu Leu Arg Ile Tyr Gln Leu 
            500                 505                 510         


Asn Ile Gln Ile Arg Glu Val Phe Ala Asn Arg Phe Thr Gln Met Phe 
        515                 520                 525             


Ala Asp Tyr Glu Val Phe Val Ile Gln Pro Ser Gln Asp Lys Glu Ser 
    530                 535                 540                 


Trp Phe Thr Asn Arg Glu Gln Met Gln Asn Phe Asp Lys Ala Ser Phe 
545                 550                 555                 560 


Leu Ser Asp Gln Pro Glu Pro Tyr Leu Pro Phe Leu Ser Arg Phe Leu 
                565                 570                 575     


Glu Thr Gln Met Phe Ala Ser Phe Ile Asp Asn Lys Ile Met Cys His 
            580                 585                 590         


Asp Asp Asp Asp Lys Asp Pro Val Leu Arg Val Phe Asp Ser Arg Val 
        595                 600                 605             


Asp Lys Ile Arg Leu Leu Asn Val Arg Thr Pro Thr Leu Arg Thr Ser 
    610                 615                 620                 


Met Tyr Gln Lys Cys Thr Thr Val Asp Glu Ala Glu Lys Ala Ile Glu 
625                 630                 635                 640 


Leu Arg Leu Ala Lys Ile Asp His Thr Ala Ile His Pro His Leu Leu 
                645                 650                 655     


Asp Met Lys Ile Gly Gln Gly Lys Tyr Glu Pro Gly Phe Phe Pro Lys 
            660                 665                 670         


Leu Gln Ser Asp Val Leu Ser Thr Gly Pro Ala Ser Asn Lys Trp Thr 
        675                 680                 685             


Lys Arg Asn Ala Pro Ala Gln Trp Arg Arg Lys Asp Arg Gln Lys Gln 
    690                 695                 700                 


His Thr Glu His Leu Arg Leu Asp Asn Asp Gln Arg Glu Lys Tyr Ile 
705                 710                 715                 720 


Gln Glu Ala Arg Thr Met Gly Ser Thr Ile Arg Gln Pro Lys Leu Ser 
                725                 730                 735     


Asn Leu Ser Pro Ser Val Ile Ala Gln Thr Asn Trp Lys Phe Val Glu 
            740                 745                 750         


Gly Leu Leu Lys Glu Cys Arg Asn Lys Thr Lys Arg Met Leu Val Glu 
        755                 760                 765             


Lys Met Gly Arg Glu Ala Val Glu Leu Gly His Gly Glu Val Asn Ile 
    770                 775                 780                 


Thr Gly Val Glu Glu Asn Thr Leu Ile Ala Ser Leu Cys Asp Leu Leu 
785                 790                 795                 800 


Glu Arg Ile Trp Ser His Gly Leu Gln Val Lys Gln Gly Lys Ser Ala 
                805                 810                 815     


Leu Trp Ser His Leu Leu His Tyr Gln Asp Asn Arg Gln Arg Lys Leu 
            820                 825                 830         


Thr Ser Gly Ser Leu Ser Thr Ser Gly Ile Leu Leu Asp Ser Glu Arg 
        835                 840                 845             


Arg Lys Ser Asp Ala Ser Ser Leu Met Pro Pro Leu Arg Ile Ser Leu 
    850                 855                 860                 


Ile Gln Asp Met Arg His Ile Gln Asn Ile Gly Glu Ile Lys Thr Asp 
865                 870                 875                 880 


Val Gly Lys Ala Arg Ala Trp Val Arg Leu Ser Met Glu Lys Lys Leu 
                885                 890                 895     


Leu Ser Arg His Leu Lys Gln Leu Leu Ser Asp His Glu Leu Thr Lys 
            900                 905                 910         


Lys Leu Tyr Lys Arg Tyr Ala Phe Leu Arg Cys Asp Asp Glu Lys Glu 
        915                 920                 925             


Gln Phe Leu Tyr His Leu Leu Ser Phe Asn Ala Val Asp Tyr Phe Cys 
    930                 935                 940                 


Phe Thr Asn Val Phe Thr Thr Ile Leu Ile Pro Tyr His Ile Leu Ile 
945                 950                 955                 960 


Val Pro Ser Lys Lys Leu Gly Gly Ser Met Phe Thr Ala Asn Pro Trp 
                965                 970                 975     


Ile Cys Ile Ser Gly Glu Leu Gly Glu Thr Gln Ile Met Gln Ile Pro 
            980                 985                 990         


Arg Asn Val Leu Glu Met Thr Phe  Glu Cys Gln Asn Leu  Gly Lys Leu 
        995                 1000                 1005             


Thr Thr  Val Gln Ile Gly His  Asp Asn Ser Gly Leu  Tyr Ala Lys 
    1010                 1015                 1020             


Trp Leu  Val Glu Tyr Val Met  Val Arg Asn Glu Ile  Thr Gly His 
    1025                 1030                 1035             


Thr Tyr  Lys Phe Pro Cys Gly  Arg Trp Leu Gly Lys  Gly Met Asp 
    1040                 1045                 1050             


Asp Gly  Ser Leu Glu Arg Ile  Leu Val Gly Glu Leu  Leu Thr Ser 
    1055                 1060                 1065             


Gln Pro  Glu Val Asp Glu Arg  Pro Cys Arg Thr Pro  Pro Leu Gln 
    1070                 1075                 1080             


Gln Ser  Pro Ser Val Ile Arg  Arg Leu Val Thr Ile  Ser Pro Asn 
    1085                 1090                 1095             


Asn Lys  Pro Lys Leu Asn Thr  Gly Gln Ile Gln Glu  Ser Ile Gly 
    1100                 1105                 1110             


Glu Ala  Val Asn Gly Ile Val  Lys His Phe His Lys  Pro Glu Lys 
    1115                 1120                 1125             


Glu Arg  Gly Ser Leu Thr Leu  Leu Leu Cys Gly Glu  Cys Gly Leu 
    1130                 1135                 1140             


Val Ser  Ala Leu Glu Gln Ala  Phe Gln His Gly Phe  Lys Ser Pro 
    1145                 1150                 1155             


Arg Leu  Phe Lys Asn Val Phe  Ile Trp Asp Phe Leu  Glu Lys Ala 
    1160                 1165                 1170             


Gln Thr  Tyr Tyr Glu Thr Leu  Glu Lys Asn Glu Val  Val Pro Glu 
    1175                 1180                 1185             


Glu Asn  Trp His Thr Arg Ala  Arg Asn Phe Cys Arg  Phe Val Thr 
    1190                 1195                 1200             


Ala Ile  Asn Asn Thr Pro Arg  Asn Ile Gly Lys Asp  Gly Lys Phe 
    1205                 1210                 1215             


Gln Met  Leu Val Cys Leu Gly  Ala Arg Asp His Leu  Leu His His 
    1220                 1225                 1230             


Trp Ile  Ala Leu Leu Ala Asp  Cys Pro Ile Thr Ala  His Met Tyr 
    1235                 1240                 1245             


Glu Asp  Val Ala Leu Ile Lys  Asp His Thr Leu Val  Asn Ser Leu 
    1250                 1255                 1260             


Ile Arg  Val Leu Gln Thr Leu  Gln Glu Phe Asn Ile  Thr Leu Glu 
    1265                 1270                 1275             


Thr Ser  Leu Val Lys Gly Ile  Asp Ile 
    1280                 1285         


<210>  4048
<211>  3088
<212>  PRT
<213>  Homo sapiens

<400>  4048

Met Glu Glu Phe Leu Gln Arg Ala Lys Ser Lys Leu Asn Arg Ser Lys 
1               5                   10                  15      


Arg Leu Glu Lys Val His Val Val Ile Gly Pro Lys Ser Cys Asp Leu 
            20                  25                  30          


Asp Ser Leu Ile Ser Thr Phe Thr Tyr Ala Tyr Phe Leu Asp Lys Val 
        35                  40                  45              


Ser Pro Pro Gly Val Leu Cys Leu Pro Val Leu Asn Ile Pro Arg Thr 
    50                  55                  60                  


Glu Phe Asn Tyr Phe Thr Glu Thr Arg Phe Ile Leu Glu Glu Leu Asn 
65                  70                  75                  80  


Ile Ser Glu Ser Phe His Ile Phe Arg Asp Glu Ile Asn Leu His Gln 
                85                  90                  95      


Leu Asn Asp Glu Gly Lys Leu Ser Ile Thr Leu Val Gly Ser Ser Val 
            100                 105                 110         


Leu Ala Ser Glu Asp Lys Thr Leu Glu Ser Ala Val Val Lys Val Ile 
        115                 120                 125             


Asn Pro Val Glu Gln Ser Asp Ala Asn Val Glu Phe Arg Glu Ser Ser 
    130                 135                 140                 


Ser Ser Leu Val Leu Lys Glu Ile Leu Gln Glu Ala Pro Glu Leu Ile 
145                 150                 155                 160 


Thr Glu Gln Leu Ala His Arg Leu Arg Gly Ser Ile Leu Phe Lys Trp 
                165                 170                 175     


Met Thr Met Glu Ser Glu Lys Ile Ser Glu Lys Gln Glu Glu Ile Leu 
            180                 185                 190         


Ser Ile Leu Glu Glu Lys Phe Pro Asn Leu Pro Pro Arg Glu Asp Ile 
        195                 200                 205             


Ile Asn Val Leu Gln Glu Thr Gln Phe Ser Ala Gln Gly Leu Ser Ile 
    210                 215                 220                 


Glu Gln Thr Met Leu Lys Asp Leu Lys Glu Leu Ser Asp Gly Glu Ile 
225                 230                 235                 240 


Lys Val Ala Ile Ser Thr Val Ser Met Asn Leu Glu Asn Cys Leu Phe 
                245                 250                 255     


His Ser Asn Ile Thr Ser Asp Leu Lys Ala Phe Thr Asp Lys Phe Gly 
            260                 265                 270         


Phe Asp Val Leu Ile Leu Phe Ser Ser Tyr Leu Ser Glu Glu Gln Gln 
        275                 280                 285             


Pro Arg Arg Gln Ile Ala Val Tyr Ser Glu Asn Met Glu Leu Cys Ser 
    290                 295                 300                 


Gln Ile Cys Cys Glu Leu Glu Glu Cys Gln Asn Pro Cys Leu Glu Leu 
305                 310                 315                 320 


Glu Pro Phe Asp Cys Gly Cys Asp Glu Ile Leu Val Tyr Gln Gln Glu 
                325                 330                 335     


Asp Pro Ser Val Thr Cys Asp Gln Val Val Leu Val Val Lys Glu Val 
            340                 345                 350         


Ile Asn Arg Arg Cys Pro Glu Met Val Ser Asn Ser Arg Thr Ser Ser 
        355                 360                 365             


Thr Glu Ala Val Ala Gly Ser Ala Pro Leu Ser Gln Gly Ser Ser Gly 
    370                 375                 380                 


Ile Met Glu Leu Tyr Gly Ser Asp Ile Glu Pro Gln Pro Ser Ser Val 
385                 390                 395                 400 


Asn Phe Ile Glu Asn Pro Pro Asp Leu Asn Asp Ser Asn Gln Ala Gln 
                405                 410                 415     


Val Asp Ala Asn Val Asp Leu Val Ser Pro Asp Ser Gly Leu Ala Thr 
            420                 425                 430         


Ile Arg Ser Ser Arg Ser Ser Lys Glu Ser Ser Val Phe Leu Ser Asp 
        435                 440                 445             


Asp Ser Pro Val Gly Glu Gly Ala Gly Pro His His Thr Leu Leu Pro 
    450                 455                 460                 


Gly Leu Asp Ser Tyr Ser Pro Ile Pro Glu Gly Ala Val Ala Glu Glu 
465                 470                 475                 480 


His Ala Trp Ser Gly Glu His Gly Glu His Phe Asp Leu Phe Asn Phe 
                485                 490                 495     


Asp Pro Ala Pro Met Ala Ser Gly Gln Ser Gln Gln Ser Ser His Ser 
            500                 505                 510         


Ala Asp Tyr Ser Pro Ala Asp Asp Phe Phe Pro Asn Ser Asp Leu Ser 
        515                 520                 525             


Glu Gly Gln Leu Pro Ala Gly Pro Glu Gly Leu Asp Gly Met Gly Thr 
    530                 535                 540                 


Asn Met Ser Asn Tyr Ser Ser Ser Ser Leu Leu Ser Gly Ala Gly Lys 
545                 550                 555                 560 


Asp Ser Leu Val Glu His Asp Glu Glu Phe Val Gln Arg Gln Asp Ser 
                565                 570                 575     


Pro Arg Asp Asn Ser Glu Arg Asn Leu Ser Leu Thr Asp Phe Val Gly 
            580                 585                 590         


Asp Glu Ser Pro Ser Pro Glu Arg Leu Lys Asn Thr Gly Lys Arg Ile 
        595                 600                 605             


Pro Pro Thr Pro Met Asn Ser Leu Val Glu Ser Ser Pro Ser Thr Glu 
    610                 615                 620                 


Glu Pro Ala Ser Leu Tyr Thr Glu Asp Met Thr Gln Lys Ala Thr Asp 
625                 630                 635                 640 


Thr Gly His Met Gly Pro Pro Gln Thr His Ala Arg Cys Ser Ser Trp 
                645                 650                 655     


Trp Gly Gly Leu Glu Ile Asp Ser Lys Asn Ile Ala Asp Ala Trp Ser 
            660                 665                 670         


Ser Ser Glu Gln Glu Ser Val Phe Gln Ser Pro Glu Ser Trp Lys Glu 
        675                 680                 685             


His Lys Pro Ser Ser Ile Asp Arg Arg Ala Ser Asp Ser Val Phe Gln 
    690                 695                 700                 


Pro Lys Ser Leu Glu Phe Thr Lys Ser Gly Pro Trp Glu Ser Glu Phe 
705                 710                 715                 720 


Gly Gln Pro Glu Leu Gly Ser Asn Asp Ile Gln Asp Lys Asn Glu Glu 
                725                 730                 735     


Ser Leu Pro Phe Gln Asn Leu Pro Met Glu Lys Ser Pro Leu Pro Asn 
            740                 745                 750         


Thr Ser Pro Gln Gly Thr Asn His Leu Ile Glu Asp Phe Ala Ser Leu 
        755                 760                 765             


Trp His Ser Gly Arg Ser Pro Thr Ala Met Pro Glu Pro Trp Gly Asn 
    770                 775                 780                 


Pro Thr Asp Asp Gly Glu Pro Ala Ala Val Ala Pro Phe Pro Ala Trp 
785                 790                 795                 800 


Ser Ala Phe Gly Lys Glu Asp His Asp Glu Ala Leu Lys Asn Thr Trp 
                805                 810                 815     


Asn Leu His Pro Thr Ser Ser Lys Thr Pro Ser Val Arg Asp Pro Asn 
            820                 825                 830         


Glu Trp Ala Met Ala Lys Ser Gly Phe Ala Phe Ser Ser Ser Glu Leu 
        835                 840                 845             


Leu Asp Asn Ser Pro Ser Glu Ile Asn Asn Glu Ala Ala Pro Glu Ile 
    850                 855                 860                 


Trp Gly Lys Lys Asn Asn Asp Ser Arg Asp His Ile Phe Ala Pro Gly 
865                 870                 875                 880 


Asn Pro Ser Ser Asp Leu Asp His Thr Trp Thr Asn Ser Lys Pro Pro 
                885                 890                 895     


Lys Glu Asp Gln Asn Gly Leu Val Asp Pro Lys Thr Arg Gly Lys Val 
            900                 905                 910         


Tyr Glu Lys Val Asp Ser Trp Asn Leu Phe Glu Glu Asn Met Lys Lys 
        915                 920                 925             


Gly Gly Ser Asp Val Leu Val Pro Trp Glu Asp Ser Phe Leu Ser Tyr 
    930                 935                 940                 


Lys Cys Ser Asp Tyr Ser Ala Ser Asn Leu Gly Glu Asp Ser Val Pro 
945                 950                 955                 960 


Ser Pro Leu Asp Thr Asn Tyr Ser Thr Ser Asp Ser Tyr Thr Ser Pro 
                965                 970                 975     


Thr Phe Ala Gly Asp Glu Lys Glu Thr Glu His Lys Pro Phe Ala Lys 
            980                 985                 990         


Glu Glu Gly Phe Glu Ser Lys Asp  Gly Asn Ser Thr Ala  Glu Glu Thr 
        995                 1000                 1005             


Asp Ile  Pro Pro Gln Ser Leu  Gln Gln Ser Ser Arg  Asn Arg Ile 
    1010                 1015                 1020             


Ser Ser  Gly Pro Gly Asn Leu  Asp Met Trp Ala Ser  Pro His Thr 
    1025                 1030                 1035             


Asp Asn  Ser Ser Glu Ile Asn  Thr Thr His Asn Leu  Asp Glu Asn 
    1040                 1045                 1050             


Glu Leu  Lys Thr Glu His Thr  Asp Gly Lys Asn Ile  Ser Met Glu 
    1055                 1060                 1065             


Asp Asp  Val Gly Glu Ser Ser  Gln Ser Ser Tyr Asp  Asp Pro Ser 
    1070                 1075                 1080             


Met Met  Gln Leu Tyr Asn Glu  Thr Asn Arg Gln Leu  Thr Leu Leu 
    1085                 1090                 1095             


His Ser  Ser Thr Asn Ser Arg  Gln Thr Ala Pro Asp  Ser Leu Asp 
    1100                 1105                 1110             


Leu Trp  Asn Arg Val Ile Leu  Glu Asp Thr Gln Ser  Thr Ala Thr 
    1115                 1120                 1125             


Ile Ser  Asp Met Asp Asn Asp  Leu Asp Trp Asp Asp  Cys Ser Gly 
    1130                 1135                 1140             


Gly Ala  Ala Ile Pro Ser Asp  Gly Gln Thr Glu Gly  Tyr Met Ala 
    1145                 1150                 1155             


Glu Gly  Ser Glu Pro Glu Thr  Arg Phe Thr Val Arg  Gln Leu Glu 
    1160                 1165                 1170             


Pro Trp  Gly Leu Glu Tyr Gln  Glu Ala Asn Gln Val  Asp Trp Glu 
    1175                 1180                 1185             


Leu Pro  Ala Ser Asp Glu His  Thr Lys Asp Ser Ala  Pro Ser Glu 
    1190                 1195                 1200             


His His  Thr Leu Asn Glu Lys  Ser Gly Gln Leu Ile  Ala Asn Ser 
    1205                 1210                 1215             


Ile Trp  Asp Ser Val Met Arg  Asp Lys Asp Met Ser  Ser Phe Met 
    1220                 1225                 1230             


Leu Pro  Gly Ser Ser His Ile  Thr Asp Ser Glu Gln  Arg Glu Leu 
    1235                 1240                 1245             


Pro Pro  Glu Ile Pro Ser His  Ser Ala Asn Val Lys  Asp Thr His 
    1250                 1255                 1260             


Ser Pro  Asp Ala Pro Ala Ala  Ser Gly Thr Ser Glu  Ser Glu Ala 
    1265                 1270                 1275             


Leu Ile  Ser His Leu Asp Lys  Gln Asp Thr Glu Arg  Glu Thr Leu 
    1280                 1285                 1290             


Gln Ser  Asp Ala Ala Ser Leu  Ala Thr Arg Leu Glu  Asn Pro Gly 
    1295                 1300                 1305             


Tyr Phe  Pro His Pro Asp Pro  Trp Lys Gly His Gly  Asp Gly Gln 
    1310                 1315                 1320             


Ser Glu  Ser Glu Lys Glu Ala  Gln Gly Ala Thr Asp  Arg Gly His 
    1325                 1330                 1335             


Leu Asp  Glu Glu Glu Val Ile  Ala Ser Gly Val Glu  Asn Ala Ser 
    1340                 1345                 1350             


Gly Ile  Ser Glu Lys Gly Gln  Ser Asp Gln Glu Leu  Ser Ser Leu 
    1355                 1360                 1365             


Val Ala  Ser Glu His Gln Glu  Ile Cys Ile Lys Ser  Gly Lys Ile 
    1370                 1375                 1380             


Ser Ser  Leu Ala Val Thr Phe  Ser Pro Gln Thr Glu  Glu Pro Glu 
    1385                 1390                 1395             


Glu Val  Leu Glu Tyr Glu Glu  Gly Ser Tyr Asn Leu  Asp Ser Arg 
    1400                 1405                 1410             


Asp Val  Gln Thr Gly Met Ser  Ala Asp Asn Leu Gln  Pro Lys Asp 
    1415                 1420                 1425             


Thr His  Glu Lys His Leu Met  Ser Gln Arg Asn Ser  Gly Glu Thr 
    1430                 1435                 1440             


Thr Glu  Thr Ser Asp Gly Met  Asn Phe Thr Lys Tyr  Val Ser Val 
    1445                 1450                 1455             


Pro Glu  Lys Asp Leu Glu Lys  Thr Glu Glu Cys Asn  Phe Leu Glu 
    1460                 1465                 1470             


Pro Glu  Asn Val Gly Gly Gly  Pro Pro His Arg Val  Pro Arg Ser 
    1475                 1480                 1485             


Leu Asp  Phe Gly Asp Val Pro  Ile Asp Ser Asp Val  His Val Ser 
    1490                 1495                 1500             


Ser Thr  Cys Ser Glu Ile Thr  Lys Asn Leu Asp Val  Lys Gly Ser 
    1505                 1510                 1515             


Glu Asn  Ser Leu Pro Gly Ala  Gly Ser Ser Gly Asn  Phe Asp Arg 
    1520                 1525                 1530             


Asp Thr  Ile Ser Ser Glu Tyr  Thr His Ser Ser Ala  Ser Ser Pro 
    1535                 1540                 1545             


Glu Leu  Asn Asp Ser Ser Val  Ala Leu Ser Ser Trp  Gly Gln Gln 
    1550                 1555                 1560             


Pro Ser  Ser Gly Tyr Gln Glu  Glu Asn Gln Gly Asn  Trp Ser Glu 
    1565                 1570                 1575             


Gln Asn  His Gln Glu Ser Glu  Leu Ile Thr Thr Asp  Gly Gln Val 
    1580                 1585                 1590             


Glu Ile  Val Thr Lys Val Lys  Asp Leu Glu Lys Asn  Arg Ile Asn 
    1595                 1600                 1605             


Glu Phe  Glu Lys Ser Phe Asp  Arg Lys Thr Pro Thr  Phe Leu Glu 
    1610                 1615                 1620             


Ile Trp  Asn Asp Ser Val Asp  Gly Asp Ser Phe Ser  Ser Leu Ser 
    1625                 1630                 1635             


Ser Pro  Glu Thr Gly Lys Tyr  Ser Glu His Ser Gly  Thr His Gln 
    1640                 1645                 1650             


Glu Ser  Asn Leu Ile Ala Ser  Tyr Gln Glu Lys Asn  Glu His Asp 
    1655                 1660                 1665             


Ile Ser  Ala Thr Val Gln Pro  Glu Asp Ala Arg Val  Ile Ser Thr 
    1670                 1675                 1680             


Ser Ser  Gly Ser Asp Asp Asp  Ser Val Gly Gly Glu  Glu Ser Ile 
    1685                 1690                 1695             


Glu Glu  Glu Ile Gln Val Ala  Asn Cys His Val Ala  Glu Asp Glu 
    1700                 1705                 1710             


Ser Arg  Ala Trp Asp Ser Leu  Asn Glu Ser Asn Lys  Phe Leu Val 
    1715                 1720                 1725             


Thr Ala  Asp Pro Lys Ser Glu  Asn Ile Tyr Asp Tyr  Leu Asp Ser 
    1730                 1735                 1740             


Ser Glu  Pro Ala Glu Asn Glu  Asn Lys Ser Asn Pro  Phe Cys Asp 
    1745                 1750                 1755             


Asn Gln  Gln Ser Ser Pro Asp  Pro Trp Thr Phe Ser  Pro Leu Thr 
    1760                 1765                 1770             


Glu Thr  Glu Met Gln Ile Thr  Ala Val Glu Lys Glu  Lys Arg Ser 
    1775                 1780                 1785             


Ser Pro  Glu Thr Gly Thr Thr  Gly Asp Val Ala Trp  Gln Ile Ser 
    1790                 1795                 1800             


Pro Lys  Ala Ser Phe Pro Lys  Asn Glu Asp Asn Ser  Gln Leu Glu 
    1805                 1810                 1815             


Met Leu  Gly Phe Ser Ala Asp  Ser Thr Glu Trp Trp  Lys Ala Ser 
    1820                 1825                 1830             


Pro Gln  Glu Gly Arg Leu Ile  Glu Ser Pro Phe Glu  Arg Glu Leu 
    1835                 1840                 1845             


Ser Asp  Ser Ser Gly Val Leu  Glu Ile Asn Ser Ser  Val His Gln 
    1850                 1855                 1860             


Asn Ala  Ser Pro Trp Gly Val  Pro Val Gln Gly Asp  Ile Glu Pro 
    1865                 1870                 1875             


Val Glu  Thr His Tyr Thr Asn  Pro Phe Ser Asp Asn  His Gln Ser 
    1880                 1885                 1890             


Pro Phe  Leu Glu Gly Asn Gly  Lys Asn Ser His Glu  Gln Leu Trp 
    1895                 1900                 1905             


Asn Ile  Gln Pro Arg Gln Pro  Asp Pro Asp Ala Asp  Lys Phe Ser 
    1910                 1915                 1920             


Gln Leu  Val Lys Leu Asp Gln  Ile Lys Glu Lys Asp  Ser Arg Glu 
    1925                 1930                 1935             


Gln Thr  Phe Val Ser Ala Ala  Gly Asp Glu Leu Thr  Pro Glu Thr 
    1940                 1945                 1950             


Pro Thr  Gln Glu Gln Cys Gln  Asp Thr Met Leu Pro  Val Cys Asp 
    1955                 1960                 1965             


His Pro  Asp Thr Ala Phe Thr  His Ala Glu Glu Asn  Ser Cys Val 
    1970                 1975                 1980             


Thr Ser  Asn Val Ser Thr Asn  Glu Gly Gln Glu Thr  Asn Gln Trp 
    1985                 1990                 1995             


Glu Gln  Glu Lys Ser Tyr Leu  Gly Glu Met Thr Asn  Ser Ser Ile 
    2000                 2005                 2010             


Ala Thr  Glu Asn Phe Pro Ala  Val Ser Ser Pro Thr  Gln Leu Ile 
    2015                 2020                 2025             


Met Lys  Pro Gly Ser Glu Trp  Asp Gly Ser Thr Pro  Ser Glu Asp 
    2030                 2035                 2040             


Ser Arg  Gly Thr Phe Val Pro  Asp Ile Leu His Gly  Asn Phe Gln 
    2045                 2050                 2055             


Glu Gly  Gly Gln Leu Ala Ser  Ala Ala Pro Asp Leu  Trp Ile Asp 
    2060                 2065                 2070             


Ala Lys  Lys Pro Phe Ser Leu  Lys Ala Asp Gly Glu  Asn Pro Asp 
    2075                 2080                 2085             


Ile Leu  Thr His Cys Glu His  Asp Ser Asn Ser Gln  Ala Ser Asp 
    2090                 2095                 2100             


Ser Pro  Asp Ile Cys His Asp  Ser Glu Ala Lys Gln  Glu Thr Glu 
    2105                 2110                 2115             


Lys His  Leu Ser Ala Cys Met  Gly Pro Glu Val Glu  Ser Ser Glu 
    2120                 2125                 2130             


Leu Cys  Leu Thr Glu Pro Glu  Ile Asp Glu Glu Pro  Ile Tyr Glu 
    2135                 2140                 2145             


Pro Gly  Arg Glu Phe Val Pro  Ser Asn Ala Glu Leu  Asp Ser Glu 
    2150                 2155                 2160             


Asn Ala  Thr Val Leu Pro Pro  Ile Gly Tyr Gln Ala  Asp Ile Lys 
    2165                 2170                 2175             


Gly Ser  Ser Gln Pro Ala Ser  His Lys Gly Ser Pro  Glu Pro Ser 
    2180                 2185                 2190             


Glu Ile  Asn Gly Asp Asn Ser  Thr Gly Leu Gln Val  Ser Glu Lys 
    2195                 2200                 2205             


Gly Ala  Ser Pro Asp Met Ala  Pro Ile Leu Glu Pro  Val Asp Arg 
    2210                 2215                 2220             


Arg Ile  Pro Arg Ile Glu Asn  Val Ala Thr Ser Ile  Phe Val Thr 
    2225                 2230                 2235             


His Gln  Glu Pro Thr Pro Glu  Gly Asp Gly Ser Trp  Ile Ser Asp 
    2240                 2245                 2250             


Ser Phe  Ser Pro Glu Ser Gln  Pro Gly Ala Arg Ala  Leu Phe Asp 
    2255                 2260                 2265             


Gly Asp  Pro His Leu Ser Thr  Glu Asn Pro Ala Leu  Val Pro Asp 
    2270                 2275                 2280             


Ala Leu  Leu Ala Ser Asp Thr  Cys Leu Asp Ile Ser  Glu Ala Ala 
    2285                 2290                 2295             


Phe Asp  His Ser Phe Ser Asp  Ala Ser Gly Leu Asn  Thr Ser Thr 
    2300                 2305                 2310             


Gly Thr  Ile Asp Asp Met Ser  Lys Leu Thr Leu Ser  Glu Gly His 
    2315                 2320                 2325             


Pro Glu  Thr Pro Val Asp Gly  Asp Leu Gly Lys Gln  Asp Ile Cys 
    2330                 2335                 2340             


Ser Ser  Glu Ala Ser Trp Gly  Asp Phe Glu Tyr Asp  Val Met Gly 
    2345                 2350                 2355             


Gln Asn  Ile Asp Glu Asp Leu  Leu Arg Glu Pro Glu  His Phe Leu 
    2360                 2365                 2370             


Tyr Gly  Gly Asp Pro Pro Leu  Glu Glu Asp Ser Leu  Lys Gln Ser 
    2375                 2380                 2385             


Leu Ala  Pro Tyr Thr Pro Pro  Phe Asp Leu Ser Tyr  Leu Thr Glu 
    2390                 2395                 2400             


Pro Ala  Gln Ser Ala Glu Thr  Ile Glu Glu Ala Gly  Ser Pro Glu 
    2405                 2410                 2415             


Asp Glu  Ser Leu Gly Cys Arg  Ala Ala Glu Ile Val  Leu Ser Ala 
    2420                 2425                 2430             


Leu Pro  Asp Arg Arg Ser Glu  Gly Asn Gln Ala Glu  Thr Lys Asn 
    2435                 2440                 2445             


Arg Leu  Pro Gly Ser Gln Leu  Ala Val Leu His Ile  Arg Glu Asp 
    2450                 2455                 2460             


Pro Glu  Ser Val Tyr Leu Pro  Val Gly Ala Gly Ser  Asn Ile Leu 
    2465                 2470                 2475             


Ser Pro  Ser Asn Val Asp Trp  Glu Val Glu Thr Asp  Asn Ser Asp 
    2480                 2485                 2490             


Leu Pro  Ala Gly Gly Asp Ile  Gly Pro Pro Asn Gly  Ala Ser Lys 
    2495                 2500                 2505             


Glu Ile  Ser Glu Leu Glu Glu  Glu Lys Thr Ile Pro  Thr Lys Glu 
    2510                 2515                 2520             


Pro Glu  Gln Ile Lys Ser Glu  Tyr Lys Glu Glu Arg  Cys Thr Glu 
    2525                 2530                 2535             


Lys Asn  Glu Asp Arg His Ala  Leu His Met Asp Tyr  Ile Leu Val 
    2540                 2545                 2550             


Asn Arg  Glu Glu Asn Ser His  Ser Lys Pro Glu Thr  Cys Glu Glu 
    2555                 2560                 2565             


Arg Glu  Ser Ile Ala Glu Leu  Glu Leu Tyr Val Gly  Ser Lys Glu 
    2570                 2575                 2580             


Thr Gly  Leu Gln Gly Thr Gln  Leu Ala Ser Phe Pro  Asp Thr Cys 
    2585                 2590                 2595             


Gln Pro  Ala Ser Leu Asn Glu  Arg Lys Gly Leu Ser  Ala Glu Lys 
    2600                 2605                 2610             


Met Ser  Ser Lys Ser Asp Thr  Arg Ser Ser Phe Glu  Ser Pro Ala 
    2615                 2620                 2625             


Gln Asp  Gln Ser Trp Met Phe  Leu Gly His Ser Glu  Val Gly Asp 
    2630                 2635                 2640             


Pro Ser  Leu Asp Ala Arg Asp  Ser Gly Pro Gly Trp  Ser Gly Lys 
    2645                 2650                 2655             


Thr Val  Glu Pro Phe Ser Glu  Leu Gly Leu Gly Glu  Gly Pro Gln 
    2660                 2665                 2670             


Leu Gln  Ile Leu Glu Glu Met  Lys Pro Leu Glu Ser  Leu Ala Leu 
    2675                 2680                 2685             


Glu Glu  Ala Ser Gly Pro Val  Ser Gln Ser Gln Lys  Ser Lys Ser 
    2690                 2695                 2700             


Arg Gly  Arg Ala Gly Pro Asp  Ala Val Thr Leu Gln  Ala Val Thr 
    2705                 2710                 2715             


His Asp  Asn Glu Trp Glu Met  Leu Ser Pro Gln Pro  Val Gln Lys 
    2720                 2725                 2730             


Asn Met  Ile Pro Asp Thr Glu  Met Glu Glu Glu Thr  Glu Phe Leu 
    2735                 2740                 2745             


Glu Leu  Gly Thr Arg Ile Ser  Arg Pro Asn Gly Leu  Leu Ser Glu 
    2750                 2755                 2760             


Asp Val  Gly Met Asp Ile Pro  Phe Glu Glu Gly Val  Leu Ser Pro 
    2765                 2770                 2775             


Ser Ala  Ala Asp Met Arg Pro  Glu Pro Pro Asn Ser  Leu Asp Leu 
    2780                 2785                 2790             


Asn Asp  Thr His Pro Arg Arg  Ile Lys Leu Thr Ala  Pro Asn Ile 
    2795                 2800                 2805             


Asn Leu  Ser Leu Asp Gln Ser  Glu Gly Ser Ile Leu  Ser Asp Asp 
    2810                 2815                 2820             


Asn Leu  Asp Ser Pro Asp Glu  Ile Asp Ile Asn Val  Asp Glu Leu 
    2825                 2830                 2835             


Asp Thr  Pro Asp Glu Ala Asp  Ser Phe Glu Tyr Thr  Gly His Asp 
    2840                 2845                 2850             


Pro Thr  Ala Asn Lys Asp Ser  Gly Gln Glu Ser Glu  Ser Ile Pro 
    2855                 2860                 2865             


Glu Tyr  Thr Ala Glu Glu Glu  Arg Glu Asp Asn Arg  Leu Trp Arg 
    2870                 2875                 2880             


Thr Val  Val Ile Gly Glu Gln  Glu Gln Arg Ile Asp  Met Lys Val 
    2885                 2890                 2895             


Ile Glu  Pro Tyr Arg Arg Val  Ile Ser His Gly Gly  Tyr Tyr Gly 
    2900                 2905                 2910             


Asp Gly  Leu Asn Ala Ile Ile  Val Phe Ala Ala Cys  Phe Leu Pro 
    2915                 2920                 2925             


Asp Ser  Ser Arg Ala Asp Tyr  His Tyr Val Met Glu  Asn Leu Phe 
    2930                 2935                 2940             


Leu Tyr  Val Ile Ser Thr Leu  Glu Leu Met Val Ala  Glu Asp Tyr 
    2945                 2950                 2955             


Met Ile  Val Tyr Leu Asn Gly  Ala Thr Pro Arg Arg  Arg Met Pro 
    2960                 2965                 2970             


Gly Leu  Gly Trp Met Lys Lys  Cys Tyr Gln Met Ile  Asp Arg Arg 
    2975                 2980                 2985             


Leu Arg  Lys Asn Leu Lys Ser  Phe Ile Ile Val His  Pro Ser Trp 
    2990                 2995                 3000             


Phe Ile  Arg Thr Ile Leu Ala  Val Thr Arg Pro Phe  Ile Ser Ser 
    3005                 3010                 3015             


Lys Phe  Ser Ser Lys Ile Lys  Tyr Val Asn Ser Leu  Ser Glu Leu 
    3020                 3025                 3030             


Ser Gly  Leu Ile Pro Met Asp  Cys Ile His Ile Pro  Glu Ser Ile 
    3035                 3040                 3045             


Ile Lys  Leu Asp Glu Glu Leu  Arg Glu Ala Ser Glu  Ala Ala Lys 
    3050                 3055                 3060             


Thr Ser  Cys Leu Tyr Asn Asp  Pro Glu Met Ser Ser  Met Glu Lys 
    3065                 3070                 3075             


Asp Ile  Asp Leu Lys Leu Lys  Glu Lys Pro 
    3080                 3085             


<210>  4049
<211>  1346
<212>  PRT
<213>  Homo sapiens

<400>  4049

Met Lys Ser Pro Arg Arg Thr Thr Leu Cys Leu Met Phe Ile Val Ile 
1               5                   10                  15      


Tyr Ser Ser Lys Ala Ala Leu Asn Trp Asn Tyr Glu Ser Thr Ile His 
            20                  25                  30          


Pro Leu Ser Leu His Glu His Glu Pro Ala Gly Glu Glu Ala Leu Arg 
        35                  40                  45              


Gln Lys Arg Ala Val Ala Thr Lys Ser Pro Thr Ala Glu Glu Tyr Thr 
    50                  55                  60                  


Val Asn Ile Glu Ile Ser Phe Glu Asn Ala Ser Phe Leu Asp Pro Ile 
65                  70                  75                  80  


Lys Ala Tyr Leu Asn Ser Leu Ser Phe Pro Ile His Gly Asn Asn Thr 
                85                  90                  95      


Asp Gln Ile Thr Asp Ile Leu Ser Ile Asn Val Thr Thr Val Cys Arg 
            100                 105                 110         


Pro Ala Gly Asn Glu Ile Trp Cys Ser Cys Glu Thr Gly Tyr Gly Trp 
        115                 120                 125             


Pro Arg Glu Arg Cys Leu His Asn Leu Ile Cys Gln Glu Arg Asp Val 
    130                 135                 140                 


Phe Leu Pro Gly His His Cys Ser Cys Leu Lys Glu Leu Pro Pro Asn 
145                 150                 155                 160 


Gly Pro Phe Cys Leu Leu Gln Glu Asp Val Thr Leu Asn Met Arg Val 
                165                 170                 175     


Arg Leu Asn Val Gly Phe Gln Glu Asp Leu Met Asn Thr Ser Ser Ala 
            180                 185                 190         


Leu Tyr Arg Ser Tyr Lys Thr Asp Leu Glu Thr Ala Phe Arg Lys Gly 
        195                 200                 205             


Tyr Gly Ile Leu Pro Gly Phe Lys Gly Val Thr Val Thr Gly Phe Lys 
    210                 215                 220                 


Ser Gly Ser Val Val Val Thr Tyr Glu Val Lys Thr Thr Pro Pro Ser 
225                 230                 235                 240 


Leu Glu Leu Ile His Lys Ala Asn Glu Gln Val Val Gln Ser Leu Asn 
                245                 250                 255     


Gln Thr Tyr Lys Met Asp Tyr Asn Ser Phe Gln Ala Val Thr Ile Asn 
            260                 265                 270         


Glu Ser Asn Phe Phe Val Thr Pro Glu Ile Ile Phe Glu Gly Asp Thr 
        275                 280                 285             


Val Ser Leu Val Cys Glu Lys Glu Val Leu Ser Ser Asn Val Ser Trp 
    290                 295                 300                 


Arg Tyr Glu Glu Gln Gln Leu Glu Ile Gln Asn Ser Ser Arg Phe Ser 
305                 310                 315                 320 


Ile Tyr Thr Ala Leu Phe Asn Asn Met Thr Ser Val Ser Lys Leu Thr 
                325                 330                 335     


Ile His Asn Ile Thr Pro Gly Asp Ala Gly Glu Tyr Val Cys Lys Leu 
            340                 345                 350         


Ile Leu Asp Ile Phe Glu Tyr Glu Cys Lys Lys Lys Ile Asp Val Met 
        355                 360                 365             


Pro Ile Gln Ile Leu Ala Asn Glu Glu Met Lys Val Met Cys Asp Asn 
    370                 375                 380                 


Asn Pro Val Ser Leu Asn Cys Cys Ser Gln Gly Asn Val Asn Trp Ser 
385                 390                 395                 400 


Lys Val Glu Trp Lys Gln Glu Gly Lys Ile Asn Ile Pro Gly Thr Pro 
                405                 410                 415     


Glu Thr Asp Ile Asp Ser Ser Cys Ser Arg Tyr Thr Leu Lys Ala Asp 
            420                 425                 430         


Gly Thr Gln Cys Pro Ser Gly Ser Ser Gly Thr Thr Val Ile Tyr Thr 
        435                 440                 445             


Cys Glu Phe Ile Ser Ala Tyr Gly Ala Arg Gly Ser Ala Asn Ile Lys 
    450                 455                 460                 


Val Thr Phe Ile Ser Val Ala Asn Leu Thr Ile Thr Pro Asp Pro Ile 
465                 470                 475                 480 


Ser Val Ser Glu Gly Gln Asn Phe Ser Ile Lys Cys Ile Ser Asp Val 
                485                 490                 495     


Ser Asn Tyr Asp Glu Val Tyr Trp Asn Thr Ser Ala Gly Ile Lys Ile 
            500                 505                 510         


Tyr Gln Arg Phe Tyr Thr Thr Arg Arg Tyr Leu Asp Gly Ala Glu Ser 
        515                 520                 525             


Val Leu Thr Val Lys Thr Ser Thr Arg Glu Trp Asn Gly Thr Tyr His 
    530                 535                 540                 


Cys Ile Phe Arg Tyr Lys Asn Ser Tyr Ser Ile Ala Thr Lys Asp Val 
545                 550                 555                 560 


Ile Val His Pro Leu Pro Leu Lys Leu Asn Ile Met Val Asp Pro Leu 
                565                 570                 575     


Glu Ala Thr Val Ser Cys Ser Gly Ser His His Ile Lys Cys Cys Ile 
            580                 585                 590         


Glu Glu Asp Gly Asp Tyr Lys Val Thr Phe His Thr Gly Ser Ser Ser 
        595                 600                 605             


Leu Pro Ala Ala Lys Glu Val Asn Lys Lys Gln Val Cys Tyr Lys His 
    610                 615                 620                 


Asn Phe Asn Ala Ser Ser Val Ser Trp Cys Ser Lys Thr Val Asp Val 
625                 630                 635                 640 


Cys Cys His Phe Thr Asn Ala Ala Asn Asn Ser Val Trp Ser Pro Ser 
                645                 650                 655     


Met Lys Leu Asn Leu Val Pro Gly Glu Asn Ile Thr Cys Gln Asp Pro 
            660                 665                 670         


Val Ile Gly Val Gly Glu Pro Gly Lys Val Ile Gln Lys Leu Cys Arg 
        675                 680                 685             


Phe Ser Asn Val Pro Ser Ser Pro Glu Ser Pro Ile Gly Gly Thr Ile 
    690                 695                 700                 


Thr Tyr Lys Cys Val Gly Ser Gln Trp Glu Glu Lys Arg Asn Asp Cys 
705                 710                 715                 720 


Ile Ser Ala Pro Ile Asn Ser Leu Leu Gln Met Ala Lys Ala Leu Ile 
                725                 730                 735     


Lys Ser Pro Ser Gln Asp Glu Met Leu Pro Thr Tyr Leu Lys Asp Leu 
            740                 745                 750         


Ser Ile Ser Ile Asp Lys Ala Glu His Glu Ile Ser Ser Ser Pro Gly 
        755                 760                 765             


Ser Leu Gly Ala Ile Ile Asn Ile Leu Asp Leu Leu Ser Thr Val Pro 
    770                 775                 780                 


Thr Gln Val Asn Ser Glu Met Met Thr His Val Leu Ser Thr Val Asn 
785                 790                 795                 800 


Val Ile Leu Gly Lys Pro Val Leu Asn Thr Trp Lys Val Leu Gln Gln 
                805                 810                 815     


Gln Trp Thr Asn Gln Ser Ser Gln Leu Leu His Ser Val Glu Arg Phe 
            820                 825                 830         


Ser Gln Ala Leu Gln Ser Gly Asp Ser Pro Pro Leu Ser Phe Ser Gln 
        835                 840                 845             


Thr Asn Val Gln Met Ser Ser Met Val Ile Lys Ser Ser His Pro Glu 
    850                 855                 860                 


Thr Tyr Gln Gln Arg Phe Val Phe Pro Tyr Phe Asp Leu Trp Gly Asn 
865                 870                 875                 880 


Val Val Ile Asp Lys Ser Tyr Leu Glu Asn Leu Gln Ser Asp Ser Ser 
                885                 890                 895     


Ile Val Thr Met Ala Phe Pro Thr Leu Gln Ala Ile Leu Ala Gln Asp 
            900                 905                 910         


Ile Gln Glu Asn Asn Phe Ala Glu Ser Leu Val Met Thr Thr Thr Val 
        915                 920                 925             


Ser His Asn Thr Thr Met Pro Phe Arg Ile Ser Met Thr Phe Lys Asn 
    930                 935                 940                 


Asn Ser Pro Ser Gly Gly Glu Thr Lys Cys Val Phe Trp Asn Phe Arg 
945                 950                 955                 960 


Leu Ala Asn Asn Thr Gly Gly Trp Asp Ser Ser Gly Cys Tyr Val Glu 
                965                 970                 975     


Glu Gly Asp Gly Asp Asn Val Thr Cys Ile Cys Asp His Leu Thr Ser 
            980                 985                 990         


Phe Ser Ile Leu Met Ser Pro Asp  Ser Pro Asp Pro Ser  Ser Leu Leu 
        995                 1000                 1005             


Gly Ile  Leu Leu Asp Ile Ile  Ser Tyr Val Gly Val  Gly Phe Ser 
    1010                 1015                 1020             


Ile Leu  Ser Leu Ala Ala Cys  Leu Val Val Glu Ala  Val Val Trp 
    1025                 1030                 1035             


Lys Ser  Val Thr Lys Asn Arg  Thr Ser Tyr Met Arg  His Thr Cys 
    1040                 1045                 1050             


Ile Val  Asn Ile Ala Ala Ser  Leu Leu Val Ala Asn  Thr Trp Phe 
    1055                 1060                 1065             


Ile Val  Val Ala Ala Ile Gln  Asp Asn Arg Tyr Ile  Leu Cys Lys 
    1070                 1075                 1080             


Thr Ala  Cys Val Ala Ala Thr  Phe Phe Ile His Phe  Phe Tyr Leu 
    1085                 1090                 1095             


Ser Val  Phe Phe Trp Met Leu  Thr Leu Gly Leu Met  Leu Phe Tyr 
    1100                 1105                 1110             


Arg Leu  Val Phe Ile Leu His  Glu Thr Ser Arg Ser  Thr Gln Lys 
    1115                 1120                 1125             


Ala Ile  Ala Phe Cys Leu Gly  Tyr Gly Cys Pro Leu  Ala Ile Ser 
    1130                 1135                 1140             


Val Ile  Thr Leu Gly Ala Thr  Gln Pro Arg Glu Val  Tyr Thr Arg 
    1145                 1150                 1155             


Lys Asn  Val Cys Trp Leu Asn  Trp Glu Asp Thr Lys  Ala Leu Leu 
    1160                 1165                 1170             


Ala Phe  Ala Ile Pro Ala Leu  Ile Ile Val Val Val  Asn Ile Thr 
    1175                 1180                 1185             


Ile Thr  Ile Val Val Ile Thr  Lys Ile Leu Arg Pro  Ser Ile Gly 
    1190                 1195                 1200             


Asp Lys  Pro Cys Lys Gln Glu  Lys Ser Ser Leu Phe  Gln Ile Ser 
    1205                 1210                 1215             


Lys Ser  Ile Gly Val Leu Thr  Pro Leu Leu Gly Leu  Thr Trp Gly 
    1220                 1225                 1230             


Phe Gly  Leu Thr Thr Val Phe  Pro Gly Thr Asn Leu  Val Phe His 
    1235                 1240                 1245             


Ile Ile  Phe Ala Ile Leu Asn  Val Phe Gln Gly Leu  Phe Ile Leu 
    1250                 1255                 1260             


Leu Phe  Gly Cys Leu Trp Asp  Leu Lys Val Gln Glu  Ala Leu Leu 
    1265                 1270                 1275             


Asn Lys  Phe Ser Leu Ser Arg  Trp Ser Ser Gln His  Ser Lys Ser 
    1280                 1285                 1290             


Thr Ser  Leu Gly Ser Ser Thr  Pro Val Phe Ser Met  Ser Ser Pro 
    1295                 1300                 1305             


Ile Ser  Arg Arg Phe Asn Asn  Leu Phe Gly Lys Thr  Gly Thr Tyr 
    1310                 1315                 1320             


Asn Val  Ser Thr Pro Glu Ala  Thr Ser Ser Ser Leu  Glu Asn Ser 
    1325                 1330                 1335             


Ser Ser  Ala Ser Ser Leu Leu  Asn 
    1340                 1345     


<210>  4050
<211>  1469
<212>  PRT
<213>  Homo sapiens

<400>  4050

Met Trp Pro Ser Gln Leu Leu Ile Phe Met Met Leu Leu Ala Pro Ile 
1               5                   10                  15      


Ile His Ala Phe Ser Arg Ala Pro Ile Pro Met Ala Val Val Arg Arg 
            20                  25                  30          


Glu Leu Ser Cys Glu Ser Tyr Pro Ile Glu Leu Arg Cys Pro Gly Thr 
        35                  40                  45              


Asp Val Ile Met Ile Glu Ser Ala Asn Tyr Gly Arg Thr Asp Asp Lys 
    50                  55                  60                  


Ile Cys Asp Ser Asp Pro Ala Gln Met Glu Asn Ile Arg Cys Tyr Leu 
65                  70                  75                  80  


Pro Asp Ala Tyr Lys Ile Met Ser Gln Arg Cys Asn Asn Arg Thr Gln 
                85                  90                  95      


Cys Ala Val Val Ala Gly Pro Asp Val Phe Pro Asp Pro Cys Pro Gly 
            100                 105                 110         


Thr Tyr Lys Tyr Leu Glu Val Gln Tyr Glu Cys Val Pro Tyr Lys Val 
        115                 120                 125             


Glu Gln Lys Val Phe Leu Cys Pro Gly Leu Leu Lys Gly Val Tyr Gln 
    130                 135                 140                 


Ser Glu His Leu Phe Glu Ser Asp His Gln Ser Gly Ala Trp Cys Lys 
145                 150                 155                 160 


Asp Pro Leu Gln Ala Ser Asp Lys Ile Tyr Tyr Met Pro Trp Thr Pro 
                165                 170                 175     


Tyr Arg Thr Asp Thr Leu Thr Glu Tyr Ser Ser Lys Asp Asp Phe Ile 
            180                 185                 190         


Ala Gly Arg Pro Thr Thr Thr Tyr Lys Leu Pro His Arg Val Asp Gly 
        195                 200                 205             


Thr Gly Phe Val Val Tyr Asp Gly Ala Leu Phe Phe Asn Lys Glu Arg 
    210                 215                 220                 


Thr Arg Asn Ile Val Lys Phe Asp Leu Arg Thr Arg Ile Lys Ser Gly 
225                 230                 235                 240 


Glu Ala Ile Ile Ala Asn Ala Asn Tyr His Asp Thr Ser Pro Tyr Arg 
                245                 250                 255     


Trp Gly Gly Lys Ser Asp Ile Asp Leu Ala Val Asp Glu Asn Gly Leu 
            260                 265                 270         


Trp Val Ile Tyr Ala Thr Glu Gln Asn Asn Gly Lys Ile Val Ile Ser 
        275                 280                 285             


Gln Leu Asn Pro Tyr Thr Leu Arg Ile Glu Gly Thr Trp Asp Thr Ala 
    290                 295                 300                 


Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met Ile Cys Gly Ile Leu 
305                 310                 315                 320 


Tyr Val Val Lys Ser Val Tyr Glu Asp Asp Asp Asn Glu Ala Thr Gly 
                325                 330                 335     


Asn Lys Ile Asp Tyr Ile Tyr Asn Thr Asp Gln Ser Lys Asp Ser Leu 
            340                 345                 350         


Val Asp Val Pro Phe Pro Asn Ser Tyr Gln Tyr Ile Ala Ala Val Asp 
        355                 360                 365             


Tyr Asn Pro Arg Asp Asn Leu Leu Tyr Val Trp Asn Asn Tyr His Val 
    370                 375                 380                 


Val Lys Tyr Ser Leu Asp Phe Gly Pro Leu Asp Ser Arg Ser Gly Gln 
385                 390                 395                 400 


Ala His His Gly Gln Val Ser Tyr Ile Ser Pro Pro Ile His Leu Asp 
                405                 410                 415     


Ser Glu Leu Glu Arg Pro Ser Val Lys Asp Ile Ser Thr Thr Gly Pro 
            420                 425                 430         


Leu Gly Met Gly Ser Thr Thr Thr Ser Thr Thr Leu Arg Thr Thr Thr 
        435                 440                 445             


Leu Ser Pro Gly Arg Ser Thr Thr Pro Ser Val Ser Gly Arg Arg Asn 
    450                 455                 460                 


Arg Ser Thr Ser Thr Pro Ser Pro Ala Val Glu Val Leu Asp Asp Met 
465                 470                 475                 480 


Thr Thr His Leu Pro Ser Ala Ser Ser Gln Ile Pro Ala Leu Glu Glu 
                485                 490                 495     


Ser Cys Glu Ala Val Glu Ala Arg Glu Ile Met Trp Phe Lys Thr Arg 
            500                 505                 510         


Gln Gly Gln Ile Ala Lys Gln Pro Cys Pro Ala Gly Thr Ile Gly Val 
        515                 520                 525             


Ser Thr Tyr Leu Cys Leu Ala Pro Asp Gly Ile Trp Asp Pro Gln Gly 
    530                 535                 540                 


Pro Asp Leu Ser Asn Cys Ser Ser Pro Trp Val Asn His Ile Thr Gln 
545                 550                 555                 560 


Lys Leu Lys Ser Gly Glu Thr Ala Ala Asn Ile Ala Arg Glu Leu Ala 
                565                 570                 575     


Glu Gln Thr Arg Asn His Leu Asn Ala Gly Asp Ile Thr Tyr Ser Val 
            580                 585                 590         


Arg Ala Met Asp Gln Leu Val Gly Leu Leu Asp Val Gln Leu Arg Asn 
        595                 600                 605             


Leu Thr Pro Gly Gly Lys Asp Ser Ala Ala Arg Ser Leu Asn Lys Leu 
    610                 615                 620                 


Gln Lys Arg Glu Arg Ser Cys Arg Ala Tyr Val Gln Ala Met Val Glu 
625                 630                 635                 640 


Thr Val Asn Asn Leu Leu Gln Pro Gln Ala Leu Asn Ala Trp Arg Asp 
                645                 650                 655     


Leu Thr Thr Ser Asp Gln Leu Arg Ala Ala Thr Met Leu Leu His Thr 
            660                 665                 670         


Val Glu Glu Ser Ala Phe Val Leu Ala Asp Asn Leu Leu Lys Thr Asp 
        675                 680                 685             


Ile Val Arg Glu Asn Thr Asp Asn Ile Lys Leu Glu Val Ala Arg Leu 
    690                 695                 700                 


Ser Thr Glu Gly Asn Leu Glu Asp Leu Lys Phe Pro Glu Asn Met Gly 
705                 710                 715                 720 


His Gly Ser Thr Ile Gln Leu Ser Ala Asn Thr Leu Lys Gln Asn Gly 
                725                 730                 735     


Arg Asn Gly Glu Ile Arg Val Ala Phe Val Leu Tyr Asn Asn Leu Gly 
            740                 745                 750         


Pro Tyr Leu Ser Thr Glu Asn Ala Ser Met Lys Leu Gly Thr Glu Ala 
        755                 760                 765             


Leu Ser Thr Asn His Ser Val Ile Val Asn Ser Pro Val Ile Thr Ala 
    770                 775                 780                 


Ala Ile Asn Lys Glu Phe Ser Asn Lys Val Tyr Leu Ala Asp Pro Val 
785                 790                 795                 800 


Val Phe Thr Val Lys His Ile Lys Gln Ser Glu Glu Asn Phe Asn Pro 
                805                 810                 815     


Asn Cys Ser Phe Trp Ser Tyr Ser Lys Arg Thr Met Thr Gly Tyr Trp 
            820                 825                 830         


Ser Thr Gln Gly Cys Arg Leu Leu Thr Thr Asn Lys Thr His Thr Thr 
        835                 840                 845             


Cys Ser Cys Asn His Leu Thr Asn Phe Ala Val Leu Met Ala His Val 
    850                 855                 860                 


Glu Val Lys His Ser Asp Ala Val His Asp Leu Leu Leu Asp Val Ile 
865                 870                 875                 880 


Thr Trp Val Gly Ile Leu Leu Ser Leu Val Cys Leu Leu Ile Cys Ile 
                885                 890                 895     


Phe Thr Phe Cys Phe Phe Arg Gly Leu Gln Ser Asp Arg Asn Thr Ile 
            900                 905                 910         


His Lys Asn Leu Cys Ile Ser Leu Phe Val Ala Glu Leu Leu Phe Leu 
        915                 920                 925             


Ile Gly Ile Asn Arg Thr Asp Gln Pro Ile Ala Cys Ala Val Phe Ala 
    930                 935                 940                 


Ala Leu Leu His Phe Phe Phe Leu Ala Ala Phe Thr Trp Met Phe Leu 
945                 950                 955                 960 


Glu Gly Val Gln Leu Tyr Ile Met Leu Val Glu Val Phe Glu Ser Glu 
                965                 970                 975     


His Ser Arg Arg Lys Tyr Phe Tyr Leu Val Gly Tyr Gly Met Pro Ala 
            980                 985                 990         


Leu Ile Val Ala Val Ser Ala Ala  Val Asp Tyr Arg Ser  Tyr Gly Thr 
        995                 1000                 1005             


Asp Lys  Val Cys Trp Leu Arg  Leu Asp Thr Tyr Phe  Ile Trp Ser 
    1010                 1015                 1020             


Phe Ile  Gly Pro Ala Thr Leu  Ile Ile Met Leu Asn  Val Ile Phe 
    1025                 1030                 1035             


Leu Gly  Ile Ala Leu Tyr Lys  Met Phe His His Thr  Ala Ile Leu 
    1040                 1045                 1050             


Lys Pro  Glu Ser Gly Cys Leu  Asp Asn Ile Asn Tyr  Glu Asp Asn 
    1055                 1060                 1065             


Arg Pro  Phe Ile Lys Ser Trp  Val Ile Gly Ala Ile  Ala Leu Leu 
    1070                 1075                 1080             


Cys Leu  Leu Gly Leu Thr Trp  Ala Phe Gly Leu Met  Tyr Ile Asn 
    1085                 1090                 1095             


Glu Ser  Thr Val Ile Met Ala  Tyr Leu Phe Thr Ile  Phe Asn Ser 
    1100                 1105                 1110             


Leu Gln  Gly Met Phe Ile Phe  Ile Phe His Cys Val  Leu Gln Lys 
    1115                 1120                 1125             


Lys Val  Arg Lys Glu Tyr Gly  Lys Cys Leu Arg Thr  His Cys Cys 
    1130                 1135                 1140             


Ser Gly  Lys Ser Thr Glu Ser  Ser Ile Gly Ser Gly  Lys Thr Ser 
    1145                 1150                 1155             


Gly Ser  Arg Thr Pro Gly Arg  Tyr Ser Thr Gly Ser  Gln Ser Arg 
    1160                 1165                 1170             


Ile Arg  Arg Met Trp Asn Asp  Thr Val Arg Lys Gln  Ser Glu Ser 
    1175                 1180                 1185             


Ser Phe  Ile Thr Gly Asp Ile  Asn Ser Ser Ala Ser  Leu Asn Arg 
    1190                 1195                 1200             


Glu Gly  Leu Leu Asn Asn Ala  Arg Asp Thr Ser Val  Met Asp Thr 
    1205                 1210                 1215             


Leu Pro  Leu Asn Gly Asn His  Gly Asn Ser Tyr Ser  Ile Ala Ser 
    1220                 1225                 1230             


Gly Glu  Tyr Leu Ser Asn Cys  Val Gln Ile Ile Asp  Arg Gly Tyr 
    1235                 1240                 1245             


Asn His  Asn Glu Thr Ala Leu  Glu Lys Lys Ile Leu  Lys Glu Leu 
    1250                 1255                 1260             


Thr Ser  Asn Tyr Ile Pro Ser  Tyr Leu Asn Asn His  Glu Arg Ser 
    1265                 1270                 1275             


Ser Glu  Gln Asn Arg Asn Leu  Met Asn Lys Leu Val  Asn Asn Leu 
    1280                 1285                 1290             


Gly Ser  Gly Arg Glu Asp Asp  Ala Ile Val Leu Asp  Asp Ala Thr 
    1295                 1300                 1305             


Ser Phe  Asn His Glu Glu Ser  Leu Gly Leu Glu Leu  Ile His Glu 
    1310                 1315                 1320             


Glu Ser  Asp Ala Pro Leu Leu  Pro Pro Arg Val Tyr  Ser Thr Glu 
    1325                 1330                 1335             


Asn His  Gln Pro His His Tyr  Thr Arg Arg Arg Ile  Pro Gln Asp 
    1340                 1345                 1350             


His Ser  Glu Ser Phe Phe Pro  Leu Leu Thr Asn Glu  His Thr Glu 
    1355                 1360                 1365             


Asp Leu  Gln Ser Pro His Arg  Asp Ser Leu Tyr Thr  Ser Met Pro 
    1370                 1375                 1380             


Thr Leu  Ala Gly Val Ala Ala  Thr Glu Ser Val Thr  Thr Ser Thr 
    1385                 1390                 1395             


Gln Thr  Glu Pro Pro Pro Ala  Lys Cys Gly Asp Ala  Glu Asp Val 
    1400                 1405                 1410             


Tyr Tyr  Lys Ser Met Pro Asn  Leu Gly Ser Arg Asn  His Val His 
    1415                 1420                 1425             


Gln Leu  His Thr Tyr Tyr Gln  Leu Gly Arg Gly Ser  Ser Asp Gly 
    1430                 1435                 1440             


Phe Ile  Val Pro Pro Asn Lys  Asp Gly Thr Pro Pro  Glu Gly Ser 
    1445                 1450                 1455             


Ser Lys  Gly Pro Ala His Leu  Val Thr Ser Leu 
    1460                 1465                 


<210>  4051
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  4051

Met Ala Lys Pro Phe Phe Arg Leu Gln Lys Phe Leu Arg Arg Thr Gln 
1               5                   10                  15      


Phe Leu Leu Phe Phe Leu Thr Ala Ala Tyr Leu Met Thr Gly Ser Leu 
            20                  25                  30          


Leu Leu Leu Gln Arg Val Arg Val Ala Leu Pro Gln Gly Pro Arg Ala 
        35                  40                  45              


Pro Gly Pro Leu Gln Thr Leu Pro Val Ala Ala Val Ala Leu Gly Val 
    50                  55                  60                  


Gly Leu Leu Asp Ser Arg Ala Leu His Asp Pro Arg Val Ser Pro Glu 
65                  70                  75                  80  


Leu Leu Leu Gly Val Asp Met Leu Gln Ser Pro Leu Thr Arg Pro Arg 
                85                  90                  95      


Pro Gly Pro Arg Trp Leu Arg Ser Arg Asn Ser Glu Leu Arg Gln Leu 
            100                 105                 110         


Arg Arg Arg Trp Phe His His Phe Met Ser Asp Ser Gln Gly Pro Pro 
        115                 120                 125             


Ala Leu Gly Pro Glu Ala Ala Arg Pro Ala Ile His Ser Arg Gly Thr 
    130                 135                 140                 


Tyr Ile Gly Cys Phe Ser Asp Asp Gly His Glu Arg Thr Leu Lys Gly 
145                 150                 155                 160 


Ala Val Phe Tyr Asp Leu Arg Lys Met Thr Val Ser His Cys Gln Asp 
                165                 170                 175     


Ala Cys Ala Glu Arg Ser Tyr Val Tyr Ala Gly Leu Glu Ala Gly Ala 
            180                 185                 190         


Glu Cys Tyr Cys Gly Asn Arg Leu Pro Ala Val Ser Val Gly Leu Glu 
        195                 200                 205             


Glu Cys Asn His Glu Cys Lys Gly Glu Lys Gly Ser Val Cys Gly Ala 
    210                 215                 220                 


Val Asp Arg Leu Ser Val Tyr Arg Val Asp Glu Leu Gln Pro Gly Ser 
225                 230                 235                 240 


Arg Lys Arg Arg Thr Ala Thr Tyr Arg Gly Cys Phe Arg Leu Pro Glu 
                245                 250                 255     


Asn Ile Thr His Ala Phe Pro Ser Ser Leu Ile Gln Ala Asn Val Thr 
            260                 265                 270         


Val Gly Thr Cys Ser Gly Phe Cys Ser Gln Lys Glu Phe Pro Leu Ala 
        275                 280                 285             


Ile Leu Arg Gly Trp Glu Cys Tyr Cys Ala Tyr Pro Thr Pro Arg Phe 
    290                 295                 300                 


Asn Leu Arg Asp Ala Met Asp Ser Ser Val Cys Gly Gln Asp Pro Glu 
305                 310                 315                 320 


Ala Gln Arg Leu Ala Glu Tyr Cys Glu Val Tyr Gln Thr Pro Val Gln 
                325                 330                 335     


Asp Thr Arg Cys Thr Asp Arg Arg Phe Leu Pro Asn Lys Ser Lys Val 
            340                 345                 350         


Phe Val Ala Leu Ser Ser Phe Pro Gly Ala Gly Asn Thr Trp Ala Arg 
        355                 360                 365             


His Leu Ile Glu His Ala Thr Gly Phe Tyr Thr Gly Ser Tyr Tyr Phe 
    370                 375                 380                 


Asp Gly Thr Leu Tyr Asn Lys Gly Phe Lys Gly Glu Lys Asp His Trp 
385                 390                 395                 400 


Arg Ser Arg Arg Thr Ile Cys Val Lys Thr His Glu Ser Gly Arg Arg 
                405                 410                 415     


Glu Ile Glu Met Phe Asp Ser Ala Ile Leu Leu Ile Arg Asn Pro Tyr 
            420                 425                 430         


Arg Ser Leu Val Ala Glu Phe Asn Arg Lys Cys Ala Gly His Leu Gly 
        435                 440                 445             


Tyr Ala Ala Asp Arg Asn Trp Lys Ser Lys Glu Trp Pro Asp Phe Val 
    450                 455                 460                 


Asn Ser Tyr Ala Ser Trp Trp Ser Ser His Val Leu Asp Trp Leu Lys 
465                 470                 475                 480 


Tyr Gly Lys Arg Leu Leu Val Val His Tyr Glu Glu Leu Arg Arg Ser 
                485                 490                 495     


Leu Val Pro Thr Leu Arg Glu Met Val Ala Phe Leu Asn Val Ser Val 
            500                 505                 510         


Ser Glu Glu Arg Leu Leu Cys Val Glu Asn Asn Lys Glu Gly Ser Phe 
        515                 520                 525             


Arg Arg Arg Gly Arg Arg Ser His Asp Pro Glu Pro Phe Thr Pro Glu 
    530                 535                 540                 


Met Lys Asp Leu Ile Asn Gly Tyr Ile Arg Thr Val Asp Gln Ala Leu 
545                 550                 555                 560 


Arg Asp His Asn Trp Thr Gly Leu Pro Arg Glu Tyr Val Pro Arg 
                565                 570                 575 


<210>  4052
<211>  722
<212>  PRT
<213>  Homo sapiens

<400>  4052

Met Leu Thr Phe Phe Leu Val Ser Gly Gly Ser Leu Trp Leu Phe Val 
1               5                   10                  15      


Glu Phe Val Leu Ser Leu Leu Glu Lys Met Gln Thr Gln Glu Ile Leu 
            20                  25                  30          


Arg Ile Leu Arg Leu Pro Glu Leu Gly Asp Leu Gly Gln Phe Phe Arg 
        35                  40                  45              


Ser Leu Ser Ala Thr Thr Leu Val Ser Met Gly Ala Leu Ala Ala Ile 
    50                  55                  60                  


Leu Ala Tyr Trp Phe Thr His Arg Pro Lys Ala Leu Gln Pro Pro Cys 
65                  70                  75                  80  


Asn Leu Leu Met Gln Ser Glu Glu Val Glu Asp Ser Gly Gly Ala Arg 
                85                  90                  95      


Arg Ser Val Ile Gly Ser Gly Pro Gln Leu Leu Thr His Tyr Tyr Asp 
            100                 105                 110         


Asp Ala Arg Thr Met Tyr Gln Val Phe Arg Arg Gly Leu Ser Ile Ser 
        115                 120                 125             


Gly Asn Gly Pro Cys Leu Gly Phe Arg Lys Pro Lys Gln Pro Tyr Gln 
    130                 135                 140                 


Trp Leu Ser Tyr Gln Glu Val Ala Asp Arg Ala Glu Phe Leu Gly Ser 
145                 150                 155                 160 


Gly Leu Leu Gln His Asn Cys Lys Ala Cys Thr Asp Gln Phe Ile Gly 
                165                 170                 175     


Val Phe Ala Gln Asn Arg Pro Glu Trp Ile Ile Val Glu Leu Ala Cys 
            180                 185                 190         


Tyr Thr Tyr Ser Met Val Val Val Pro Leu Tyr Asp Thr Leu Gly Pro 
        195                 200                 205             


Gly Ala Ile Arg Tyr Ile Ile Asn Thr Ala Asp Ile Ser Thr Val Ile 
    210                 215                 220                 


Val Asp Lys Pro Gln Lys Ala Val Leu Leu Leu Glu His Val Glu Arg 
225                 230                 235                 240 


Lys Glu Thr Pro Gly Leu Lys Leu Ile Ile Leu Met Asp Pro Phe Glu 
                245                 250                 255     


Glu Ala Leu Lys Glu Arg Gly Gln Lys Cys Gly Val Val Ile Lys Ser 
            260                 265                 270         


Met Gln Ala Val Glu Asp Cys Gly Gln Glu Asn His Gln Ala Pro Val 
        275                 280                 285             


Pro Pro Gln Pro Asp Asp Leu Ser Ile Val Cys Phe Thr Ser Gly Thr 
    290                 295                 300                 


Thr Gly Asn Pro Lys Gly Ala Met Leu Thr His Gly Asn Val Val Ala 
305                 310                 315                 320 


Asp Phe Ser Gly Phe Leu Lys Val Thr Glu Ser Gln Trp Ala Pro Thr 
                325                 330                 335     


Cys Ala Asp Val His Ile Ser Tyr Leu Pro Leu Ala His Met Phe Glu 
            340                 345                 350         


Arg Met Val Gln Ser Val Val Tyr Cys His Gly Gly Arg Val Gly Phe 
        355                 360                 365             


Phe Gln Gly Asp Ile Arg Leu Leu Ser Asp Asp Met Lys Ala Leu Cys 
    370                 375                 380                 


Pro Thr Ile Phe Pro Val Val Pro Arg Leu Leu Asn Arg Met Tyr Asp 
385                 390                 395                 400 


Lys Ile Phe Ser Gln Ala Asn Thr Pro Leu Lys Arg Trp Leu Leu Glu 
                405                 410                 415     


Phe Ala Ala Lys Arg Lys Gln Ala Glu Val Arg Ser Gly Ile Ile Arg 
            420                 425                 430         


Asn Asp Ser Ile Trp Asp Glu Leu Phe Phe Asn Lys Ile Gln Ala Ser 
        435                 440                 445             


Leu Gly Gly Cys Val Arg Met Ile Val Thr Gly Ala Ala Pro Ala Ser 
    450                 455                 460                 


Pro Thr Val Leu Gly Phe Leu Arg Ala Ala Leu Gly Cys Gln Val Tyr 
465                 470                 475                 480 


Glu Gly Tyr Gly Gln Thr Glu Cys Thr Ala Gly Cys Thr Phe Thr Thr 
                485                 490                 495     


Pro Gly Asp Trp Thr Ser Gly His Val Gly Ala Pro Leu Pro Cys Asn 
            500                 505                 510         


His Ile Lys Leu Val Asp Val Glu Glu Leu Asn Tyr Trp Ala Cys Lys 
        515                 520                 525             


Gly Glu Gly Glu Ile Cys Val Arg Gly Pro Asn Val Phe Lys Gly Tyr 
    530                 535                 540                 


Leu Lys Asp Pro Asp Arg Thr Lys Glu Ala Leu Asp Ser Asp Gly Trp 
545                 550                 555                 560 


Leu His Thr Gly Asp Ile Gly Lys Trp Leu Pro Ala Gly Thr Leu Lys 
                565                 570                 575     


Ile Ile Asp Arg Lys Lys His Ile Phe Lys Leu Ala Gln Gly Glu Tyr 
            580                 585                 590         


Val Ala Pro Glu Lys Ile Glu Asn Ile Tyr Ile Arg Ser Gln Pro Val 
        595                 600                 605             


Ala Gln Ile Tyr Val His Gly Asp Ser Leu Lys Ala Phe Leu Val Gly 
    610                 615                 620                 


Ile Val Val Pro Asp Pro Glu Val Met Pro Ser Trp Ala Gln Lys Arg 
625                 630                 635                 640 


Gly Ile Glu Gly Thr Tyr Ala Asp Leu Cys Thr Asn Lys Asp Leu Lys 
                645                 650                 655     


Lys Ala Ile Leu Glu Asp Met Val Arg Leu Gly Lys Glu Ser Gly Leu 
            660                 665                 670         


His Ser Phe Glu Gln Val Lys Ala Ile His Ile His Ser Asp Met Phe 
        675                 680                 685             


Ser Val Gln Asn Gly Leu Leu Thr Pro Thr Leu Lys Ala Lys Arg Pro 
    690                 695                 700                 


Glu Leu Arg Glu Tyr Phe Lys Lys Gln Ile Glu Glu Leu Tyr Ser Ile 
705                 710                 715                 720 


Ser Met 
        


<210>  4053
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  4053

Met Ala Gly Gly Met Lys Val Ala Val Ser Pro Ala Val Gly Pro Gly 
1               5                   10                  15      


Pro Trp Gly Ser Gly Val Gly Gly Gly Gly Thr Val Arg Leu Leu Leu 
            20                  25                  30          


Ile Leu Ser Gly Cys Leu Val Tyr Gly Thr Ala Glu Thr Asp Val Asn 
        35                  40                  45              


Val Val Met Leu Gln Glu Ser Gln Val Cys Glu Lys Arg Ala Ser Gln 
    50                  55                  60                  


Gln Phe Cys Tyr Thr Asn Val Leu Ile Pro Lys Trp His Asp Ile Trp 
65                  70                  75                  80  


Thr Arg Ile Gln Ile Arg Val Asn Ser Ser Arg Leu Val Arg Val Thr 
                85                  90                  95      


Gln Val Glu Asn Glu Glu Lys Leu Lys Glu Leu Glu Gln Ser Gln Ile 
            100                 105                 110         


Phe Tyr Tyr Ser Thr Gly Met Thr Val Gly Ile Val Ala Ser Leu Leu 
        115                 120                 125             


Ile Ile Ile Phe Ile Leu Ser Lys Phe Met Pro Lys Lys Ser Pro Ile 
    130                 135                 140                 


Tyr Val Ile Leu Val Gly Gly Trp Ser Phe Ser Leu Tyr Leu Ile Gln 
145                 150                 155                 160 


Leu Val Phe Lys Asn Leu Gln Glu Ile Trp Arg Cys Tyr Trp Gln Tyr 
                165                 170                 175     


Leu Leu Ser Tyr Val Leu Thr Val Gly Phe Met Ser Phe Ala Val Cys 
            180                 185                 190         


Tyr Lys Tyr Gly Pro Leu Glu Asn Glu Arg Ser Ile Asn Leu Leu Thr 
        195                 200                 205             


Trp Thr Leu Gln Leu Met Gly Leu Cys Phe Met Tyr Ser Gly Ile Gln 
    210                 215                 220                 


Ile Pro His Ile Ala Leu Ala Ile Ile Ile Ile Ala Leu Cys Thr Lys 
225                 230                 235                 240 


Asn Leu Glu His Pro Ile Gln Trp Leu Tyr Ile Thr Cys Arg Lys Val 
                245                 250                 255     


Cys Lys Gly Ala Glu Lys Pro Val Pro Pro Arg Leu Leu Thr Glu Glu 
            260                 265                 270         


Glu Tyr Arg Ile Gln Gly Glu Val Glu Thr Arg Lys Ala Leu Glu Glu 
        275                 280                 285             


Leu Arg Glu Phe Cys Asn Ser Pro Asp Cys Ser Ala Trp Lys Thr Val 
    290                 295                 300                 


Ser Arg Ile Gln Ser Pro Lys Arg Phe Ala Asp Phe Val Glu Gly Ser 
305                 310                 315                 320 


Ser His Leu Thr Pro Asn Glu Val Ser Val His Glu Gln Glu Tyr Gly 
                325                 330                 335     


Leu Gly Ser Ile Ile Ala Gln Asp Glu Ile Tyr Glu Glu Ala Ser Ser 
            340                 345                 350         


Glu Glu Glu Asp Ser Tyr Ser Arg Cys Pro Ala Ile Thr Gln Asn Asn 
        355                 360                 365             


Phe Leu Thr 
    370     


<210>  4054
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  4054

Met Arg Leu Gly Ser Pro Gly Leu Leu Phe Leu Leu Phe Ser Ser Leu 
1               5                   10                  15      


Arg Ala Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp 
            20                  25                  30          


Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn 
        35                  40                  45              


Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr 
    50                  55                  60                  


Tyr His Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr 
65                  70                  75                  80  


Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe 
                85                  90                  95      


Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His 
            100                 105                 110         


Cys Leu Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val 
        115                 120                 125             


Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser 
    130                 135                 140                 


Ala Pro His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser 
145                 150                 155                 160 


Ile Asn Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp 
                165                 170                 175     


Asn Ser Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn 
            180                 185                 190         


Met Arg Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr 
        195                 200                 205             


Pro Ser Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln 
    210                 215                 220                 


Asn Leu Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp 
225                 230                 235                 240 


Lys Ile Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
                245                 250                 255     


Trp Ser Ile Leu Ala Val Leu Cys Leu Leu Val Val Val Ala Val Ala 
            260                 265                 270         


Ile Gly Trp Val Cys Arg Asp Arg Cys Leu Gln His Ser Tyr Ala Gly 
        275                 280                 285             


Ala Trp Ala Val Ser Pro Glu Thr Glu Leu Thr Gly His Val 
    290                 295                 300         


<210>  4055
<211>  581
<212>  PRT
<213>  Homo sapiens

<400>  4055

Met Gly Glu Lys Met Ala Glu Glu Glu Arg Phe Pro Asn Thr Thr His 
1               5                   10                  15      


Glu Gly Phe Asn Val Thr Leu His Thr Thr Leu Val Val Thr Thr Lys 
            20                  25                  30          


Leu Val Leu Pro Thr Pro Gly Lys Pro Ile Leu Pro Val Gln Thr Gly 
        35                  40                  45              


Glu Gln Ala Gln Gln Glu Glu Gln Ser Ser Gly Met Thr Ile Phe Phe 
    50                  55                  60                  


Ser Leu Leu Val Leu Ala Ile Cys Ile Ile Leu Val His Leu Leu Ile 
65                  70                  75                  80  


Arg Tyr Arg Leu His Phe Leu Pro Glu Ser Val Ala Val Val Ser Leu 
                85                  90                  95      


Gly Ile Leu Met Gly Ala Val Ile Lys Ile Ile Glu Phe Lys Lys Leu 
            100                 105                 110         


Ala Asn Trp Lys Glu Glu Glu Met Phe Arg Pro Asn Met Phe Phe Leu 
        115                 120                 125             


Leu Leu Leu Pro Pro Ile Ile Phe Glu Ser Gly Tyr Ser Leu His Lys 
    130                 135                 140                 


Gly Asn Phe Phe Gln Asn Ile Gly Ser Ile Thr Leu Phe Ala Val Phe 
145                 150                 155                 160 


Gly Thr Ala Ile Ser Ala Phe Val Val Gly Gly Gly Ile Tyr Phe Leu 
                165                 170                 175     


Gly Gln Ala Asp Val Ile Ser Lys Leu Asn Met Thr Asp Ser Phe Ala 
            180                 185                 190         


Phe Gly Ser Leu Ile Ser Ala Val Asp Pro Val Ala Thr Ile Ala Ile 
        195                 200                 205             


Phe Asn Ala Leu His Val Asp Pro Val Leu Asn Met Leu Val Phe Gly 
    210                 215                 220                 


Glu Ser Ile Leu Asn Asp Ala Val Ser Ile Val Leu Thr Asn Thr Ala 
225                 230                 235                 240 


Glu Gly Leu Thr Arg Lys Asn Met Ser Asp Val Ser Gly Trp Gln Thr 
                245                 250                 255     


Phe Leu Gln Ala Leu Asp Tyr Phe Leu Lys Met Phe Phe Gly Ser Ala 
            260                 265                 270         


Ala Leu Gly Thr Leu Thr Gly Leu Ile Ser Ala Leu Val Leu Lys His 
        275                 280                 285             


Ile Asp Leu Arg Lys Thr Pro Ser Leu Glu Phe Gly Met Met Ile Ile 
    290                 295                 300                 


Phe Ala Tyr Leu Pro Tyr Gly Leu Ala Glu Gly Ile Ser Leu Ser Gly 
305                 310                 315                 320 


Ile Met Ala Ile Leu Phe Ser Gly Ile Val Met Ser His Tyr Thr His 
                325                 330                 335     


His Asn Leu Ser Pro Val Thr Gln Ile Leu Met Gln Gln Thr Leu Arg 
            340                 345                 350         


Thr Val Ala Phe Leu Cys Glu Thr Cys Val Phe Ala Phe Leu Gly Leu 
        355                 360                 365             


Ser Ile Phe Ser Phe Pro His Lys Phe Glu Ile Ser Phe Val Ile Trp 
    370                 375                 380                 


Cys Ile Val Leu Val Leu Phe Gly Arg Ala Val Asn Ile Phe Pro Leu 
385                 390                 395                 400 


Ser Tyr Leu Leu Asn Phe Phe Arg Asp His Lys Ile Thr Pro Lys Met 
                405                 410                 415     


Met Phe Ile Met Trp Phe Ser Gly Leu Arg Gly Ala Ile Pro Tyr Ala 
            420                 425                 430         


Leu Ser Leu His Leu Asp Leu Glu Pro Met Glu Lys Arg Gln Leu Ile 
        435                 440                 445             


Gly Thr Thr Thr Ile Val Ile Val Leu Phe Thr Ile Leu Leu Leu Gly 
    450                 455                 460                 


Gly Ser Thr Met Pro Leu Ile Arg Leu Met Asp Ile Glu Asp Ala Lys 
465                 470                 475                 480 


Ala His Arg Arg Asn Lys Lys Asp Val Asn Leu Ser Lys Thr Glu Lys 
                485                 490                 495     


Met Gly Asn Thr Val Glu Ser Glu His Leu Ser Glu Leu Thr Glu Glu 
            500                 505                 510         


Glu Tyr Glu Ala His Tyr Ile Arg Arg Gln Asp Leu Lys Gly Phe Val 
        515                 520                 525             


Trp Leu Asp Ala Lys Tyr Leu Asn Pro Phe Phe Thr Arg Arg Leu Thr 
    530                 535                 540                 


Gln Glu Asp Leu His His Gly Arg Ile Gln Met Lys Thr Leu Thr Asn 
545                 550                 555                 560 


Lys Trp Tyr Glu Glu Val Arg Gln Gly Pro Ser Gly Ser Glu Asp Asp 
                565                 570                 575     


Glu Gln Glu Leu Leu 
            580     


<210>  4056
<211>  1168
<212>  PRT
<213>  Homo sapiens

<400>  4056

Met Ser Trp Phe Ser Gly Leu Leu Val Pro Lys Val Asp Glu Arg Lys 
1               5                   10                  15      


Thr Ala Trp Gly Glu Arg Asn Gly Gln Lys Arg Ser Arg Arg Arg Gly 
            20                  25                  30          


Thr Arg Ala Gly Gly Phe Cys Thr Pro Arg Tyr Met Ser Cys Leu Arg 
        35                  40                  45              


Asp Ala Glu Pro Pro Ser Pro Thr Pro Ala Gly Pro Pro Arg Cys Pro 
    50                  55                  60                  


Trp Gln Asp Asp Ala Phe Ile Arg Arg Gly Gly Pro Gly Lys Gly Lys 
65                  70                  75                  80  


Glu Leu Gly Leu Arg Ala Val Ala Leu Gly Phe Glu Asp Thr Glu Val 
                85                  90                  95      


Thr Thr Thr Ala Gly Gly Thr Ala Glu Val Ala Pro Asp Ala Val Pro 
            100                 105                 110         


Arg Ser Gly Arg Ser Cys Trp Arg Arg Leu Val Gln Val Phe Gln Ser 
        115                 120                 125             


Lys Gln Phe Arg Ser Ala Lys Leu Glu Arg Leu Tyr Gln Arg Tyr Phe 
    130                 135                 140                 


Phe Gln Met Asn Gln Ser Ser Leu Thr Leu Leu Met Ala Val Leu Val 
145                 150                 155                 160 


Leu Leu Thr Ala Val Leu Leu Ala Phe His Ala Ala Pro Ala Arg Pro 
                165                 170                 175     


Gln Pro Ala Tyr Val Ala Leu Leu Ala Cys Ala Ala Ala Leu Phe Val 
            180                 185                 190         


Gly Leu Met Val Val Cys Asn Arg His Ser Phe Arg Gln Asp Ser Met 
        195                 200                 205             


Trp Val Val Ser Tyr Val Val Leu Gly Ile Leu Ala Ala Val Gln Val 
    210                 215                 220                 


Gly Gly Ala Leu Ala Ala Asp Pro Arg Ser Pro Ser Ala Gly Leu Trp 
225                 230                 235                 240 


Cys Pro Val Phe Phe Val Tyr Ile Ala Tyr Thr Leu Leu Pro Ile Arg 
                245                 250                 255     


Met Arg Ala Ala Val Leu Ser Gly Leu Gly Leu Ser Thr Leu His Leu 
            260                 265                 270         


Ile Leu Ala Trp Gln Leu Asn Arg Gly Asp Ala Phe Leu Trp Lys Gln 
        275                 280                 285             


Leu Gly Ala Asn Val Leu Leu Phe Leu Cys Thr Asn Val Ile Gly Ile 
    290                 295                 300                 


Cys Thr His Tyr Pro Ala Glu Val Ser Gln Arg Gln Ala Phe Gln Glu 
305                 310                 315                 320 


Thr Arg Gly Tyr Ile Gln Ala Arg Leu His Leu Gln His Glu Asn Arg 
                325                 330                 335     


Gln Gln Glu Arg Leu Leu Leu Ser Val Leu Pro Gln His Val Ala Met 
            340                 345                 350         


Glu Met Lys Glu Asp Ile Asn Thr Lys Lys Glu Asp Met Met Phe His 
        355                 360                 365             


Lys Ile Tyr Ile Gln Lys His Asp Asn Val Ser Ile Leu Phe Ala Asp 
    370                 375                 380                 


Ile Glu Gly Phe Thr Ser Leu Ala Ser Gln Cys Thr Ala Gln Glu Leu 
385                 390                 395                 400 


Val Met Thr Leu Asn Glu Leu Phe Ala Arg Phe Asp Lys Leu Ala Ala 
                405                 410                 415     


Glu Asn His Cys Leu Arg Ile Lys Ile Leu Gly Asp Cys Tyr Tyr Cys 
            420                 425                 430         


Val Ser Gly Leu Pro Glu Ala Arg Ala Asp His Ala His Cys Cys Val 
        435                 440                 445             


Glu Met Gly Val Asp Met Ile Glu Ala Ile Ser Leu Val Arg Glu Val 
    450                 455                 460                 


Thr Gly Val Asn Val Asn Met Arg Val Gly Ile His Ser Gly Arg Val 
465                 470                 475                 480 


His Cys Gly Val Leu Gly Leu Arg Lys Trp Gln Phe Asp Val Trp Ser 
                485                 490                 495     


Asn Asp Val Thr Leu Ala Asn His Met Glu Ala Gly Gly Arg Ala Gly 
            500                 505                 510         


Arg Ile His Ile Thr Arg Ala Thr Leu Gln Tyr Leu Asn Gly Asp Tyr 
        515                 520                 525             


Glu Val Glu Pro Gly Arg Gly Gly Glu Arg Asn Ala Tyr Leu Lys Glu 
    530                 535                 540                 


Gln His Ile Glu Thr Phe Leu Ile Leu Gly Ala Ser Gln Lys Arg Lys 
545                 550                 555                 560 


Glu Glu Lys Ala Met Leu Ala Lys Leu Gln Arg Thr Arg Ala Asn Ser 
                565                 570                 575     


Met Glu Gly Leu Met Pro Arg Trp Val Pro Asp Arg Ala Phe Ser Arg 
            580                 585                 590         


Thr Lys Asp Ser Lys Ala Phe Arg Gln Met Gly Ile Asp Asp Ser Ser 
        595                 600                 605             


Lys Asp Asn Arg Gly Thr Gln Asp Ala Leu Asn Pro Glu Asp Glu Val 
    610                 615                 620                 


Asp Glu Phe Leu Ser Arg Ala Ile Asp Ala Arg Ser Ile Asp Gln Leu 
625                 630                 635                 640 


Arg Lys Asp His Val Arg Arg Phe Leu Leu Thr Phe Gln Arg Glu Asp 
                645                 650                 655     


Leu Glu Lys Lys Tyr Ser Arg Lys Val Asp Pro Arg Phe Gly Ala Tyr 
            660                 665                 670         


Val Ala Cys Ala Leu Leu Val Phe Cys Phe Ile Cys Phe Ile Gln Leu 
        675                 680                 685             


Leu Ile Phe Pro His Ser Thr Leu Met Leu Gly Ile Tyr Ala Ser Ile 
    690                 695                 700                 


Phe Leu Leu Leu Leu Ile Thr Val Leu Ile Cys Ala Val Tyr Ser Cys 
705                 710                 715                 720 


Gly Ser Leu Phe Pro Lys Ala Leu Gln Arg Leu Ser Arg Ser Ile Val 
                725                 730                 735     


Arg Ser Arg Ala His Ser Thr Ala Val Gly Ile Phe Ser Val Leu Leu 
            740                 745                 750         


Val Phe Thr Ser Ala Ile Ala Asn Met Phe Thr Cys Asn His Thr Pro 
        755                 760                 765             


Ile Arg Ser Cys Ala Ala Arg Met Leu Asn Leu Thr Pro Ala Asp Ile 
    770                 775                 780                 


Thr Ala Cys His Leu Gln Gln Leu Asn Tyr Ser Leu Gly Leu Asp Ala 
785                 790                 795                 800 


Pro Leu Cys Glu Gly Thr Met Pro Thr Cys Ser Phe Pro Glu Tyr Phe 
                805                 810                 815     


Ile Gly Asn Met Leu Leu Ser Leu Leu Ala Ser Ser Val Phe Leu His 
            820                 825                 830         


Ile Ser Ser Ile Gly Lys Leu Ala Met Ile Phe Val Leu Gly Leu Ile 
        835                 840                 845             


Tyr Leu Val Leu Leu Leu Leu Gly Pro Pro Ala Thr Ile Phe Asp Asn 
    850                 855                 860                 


Tyr Asp Leu Leu Leu Gly Val His Gly Leu Ala Ser Ser Asn Glu Thr 
865                 870                 875                 880 


Phe Asp Gly Leu Asp Cys Pro Ala Ala Gly Arg Val Ala Leu Lys Tyr 
                885                 890                 895     


Met Thr Pro Val Ile Leu Leu Val Phe Ala Leu Ala Leu Tyr Leu His 
            900                 905                 910         


Ala Gln Gln Val Glu Ser Thr Ala Arg Leu Asp Phe Leu Trp Lys Leu 
        915                 920                 925             


Gln Ala Thr Gly Glu Lys Glu Glu Met Glu Glu Leu Gln Ala Tyr Asn 
    930                 935                 940                 


Arg Arg Leu Leu His Asn Ile Leu Pro Lys Asp Val Ala Ala His Phe 
945                 950                 955                 960 


Leu Ala Arg Glu Arg Arg Asn Asp Glu Leu Tyr Tyr Gln Ser Cys Glu 
                965                 970                 975     


Cys Val Ala Val Met Phe Ala Ser Ile Ala Asn Phe Ser Glu Phe Tyr 
            980                 985                 990         


Val Glu Leu Glu Ala Asn Asn Glu  Gly Val Glu Cys Leu  Arg Leu Leu 
        995                 1000                 1005             


Asn Glu  Ile Ile Ala Asp Phe  Asp Glu Ile Ile Ser  Glu Glu Arg 
    1010                 1015                 1020             


Phe Arg  Gln Leu Glu Lys Ile  Lys Thr Ile Gly Ser  Thr Tyr Met 
    1025                 1030                 1035             


Ala Ala  Ser Gly Leu Asn Ala  Ser Thr Tyr Asp Gln  Val Gly Arg 
    1040                 1045                 1050             


Ser His  Ile Thr Ala Leu Ala  Asp Tyr Ala Met Arg  Leu Met Glu 
    1055                 1060                 1065             


Gln Met  Lys His Ile Asn Glu  His Ser Phe Asn Asn  Phe Gln Met 
    1070                 1075                 1080             


Lys Ile  Gly Leu Asn Met Gly  Pro Val Val Ala Gly  Val Ile Gly 
    1085                 1090                 1095             


Ala Arg  Lys Pro Gln Tyr Asp  Ile Trp Gly Asn Thr  Val Asn Val 
    1100                 1105                 1110             


Ser Ser  Arg Met Asp Ser Thr  Gly Val Pro Asp Arg  Ile Gln Val 
    1115                 1120                 1125             


Thr Thr  Asp Leu Tyr Gln Val  Leu Ala Ala Lys Gly  Tyr Gln Leu 
    1130                 1135                 1140             


Glu Cys  Arg Gly Val Val Lys  Val Lys Gly Lys Gly  Glu Met Thr 
    1145                 1150                 1155             


Thr Tyr  Phe Leu Asn Gly Gly  Pro Ser Ser 
    1160                 1165             


<210>  4057
<211>  675
<212>  PRT
<213>  Homo sapiens

<400>  4057

Met Glu Gly Arg Pro Pro Pro Glu Gly Arg Pro Pro Pro Arg Pro Arg 
1               5                   10                  15      


Thr Gly Arg Ala Pro Arg Gly Arg Arg Arg Ala Val Phe Ala Ala Val 
            20                  25                  30          


Leu His Trp Ser His Ile Thr His Leu Phe Glu Asn Asp Arg His Phe 
        35                  40                  45              


Ser His Leu Ser Thr Leu Glu Arg Glu Met Ala Phe Arg Thr Glu Met 
    50                  55                  60                  


Gly Leu Tyr Tyr Ser Tyr Phe Lys Thr Ile Val Glu Ala Pro Ser Phe 
65                  70                  75                  80  


Leu Asn Gly Val Trp Met Ile Met Asn Asp Lys Leu Thr Glu Tyr Pro 
                85                  90                  95      


Leu Val Ile Asn Thr Leu Lys Arg Phe Asn Leu Tyr Pro Glu Val Ile 
            100                 105                 110         


Leu Ala Ser Trp Tyr Arg Ile Tyr Thr Lys Ile Met Asp Leu Ile Gly 
        115                 120                 125             


Ile Gln Thr Lys Ile Cys Trp Thr Val Thr Arg Gly Glu Gly Leu Ser 
    130                 135                 140                 


Pro Ile Glu Ser Cys Glu Gly Leu Gly Asp Pro Ala Cys Phe Tyr Val 
145                 150                 155                 160 


Ala Val Ile Phe Ile Leu Asn Gly Leu Met Met Ala Leu Phe Phe Ile 
                165                 170                 175     


Tyr Gly Thr Tyr Leu Ser Gly Ser Arg Leu Gly Gly Leu Val Thr Val 
            180                 185                 190         


Leu Cys Phe Phe Phe Asn His Gly Glu Cys Thr Arg Val Met Trp Thr 
        195                 200                 205             


Pro Pro Leu Arg Glu Ser Phe Ser Tyr Pro Phe Leu Val Leu Gln Met 
    210                 215                 220                 


Leu Leu Val Thr His Ile Leu Arg Ala Thr Lys Leu Tyr Arg Gly Ser 
225                 230                 235                 240 


Leu Ile Ala Leu Cys Ile Ser Asn Val Phe Phe Met Leu Pro Trp Gln 
                245                 250                 255     


Phe Ala Gln Phe Val Leu Leu Thr Gln Ile Ala Ser Leu Phe Ala Val 
            260                 265                 270         


Tyr Val Val Gly Tyr Ile Asp Ile Cys Lys Leu Arg Lys Ile Ile Tyr 
        275                 280                 285             


Ile His Met Ile Ser Leu Ala Leu Cys Phe Val Leu Met Phe Gly Asn 
    290                 295                 300                 


Ser Met Leu Leu Thr Ser Tyr Tyr Ala Ser Ser Leu Val Ile Ile Trp 
305                 310                 315                 320 


Gly Ile Leu Ala Met Lys Pro His Phe Leu Lys Ile Asn Val Ser Glu 
                325                 330                 335     


Leu Ser Leu Trp Val Ile Gln Gly Cys Phe Trp Leu Phe Gly Thr Val 
            340                 345                 350         


Ile Leu Lys Tyr Leu Thr Ser Lys Ile Phe Gly Ile Ala Asp Asp Ala 
        355                 360                 365             


His Ile Gly Asn Leu Leu Thr Ser Lys Phe Phe Ser Tyr Lys Asp Phe 
    370                 375                 380                 


Asp Thr Leu Leu Tyr Thr Cys Ala Ala Glu Phe Asp Phe Met Glu Lys 
385                 390                 395                 400 


Glu Thr Pro Leu Arg Tyr Thr Lys Thr Leu Leu Leu Pro Val Val Leu 
                405                 410                 415     


Val Val Phe Val Ala Ile Val Arg Lys Ile Ile Ser Asp Met Trp Gly 
            420                 425                 430         


Val Leu Ala Lys Gln Gln Thr His Val Arg Lys His Gln Phe Asp His 
        435                 440                 445             


Gly Glu Leu Val Tyr His Ala Leu Gln Leu Leu Ala Tyr Thr Ala Leu 
    450                 455                 460                 


Gly Ile Leu Ile Met Arg Leu Lys Leu Phe Leu Thr Pro His Met Cys 
465                 470                 475                 480 


Val Met Ala Ser Leu Ile Cys Ser Arg Gln Leu Phe Gly Trp Leu Phe 
                485                 490                 495     


Cys Lys Val His Pro Gly Ala Ile Val Phe Ala Ile Leu Ala Ala Met 
            500                 505                 510         


Ser Ile Gln Gly Ser Ala Asn Leu Gln Thr Gln Trp Asn Ile Val Gly 
        515                 520                 525             


Glu Phe Ser Asn Leu Pro Gln Glu Glu Leu Ile Glu Trp Ile Lys Tyr 
    530                 535                 540                 


Ser Thr Lys Pro Asp Ala Val Phe Ala Gly Ala Met Pro Thr Met Ala 
545                 550                 555                 560 


Ser Val Lys Leu Ser Ala Leu Arg Pro Ile Val Asn His Pro His Tyr 
                565                 570                 575     


Glu Asp Ala Gly Leu Arg Ala Arg Thr Lys Ile Val Tyr Ser Met Tyr 
            580                 585                 590         


Ser Arg Lys Ala Ala Glu Glu Val Lys Arg Glu Leu Ile Lys Leu Lys 
        595                 600                 605             


Val Asn Tyr Tyr Ile Leu Glu Glu Ser Trp Cys Val Arg Arg Ser Lys 
    610                 615                 620                 


Pro Gly Cys Ser Met Pro Glu Ile Trp Asp Val Glu Asp Pro Ala Asn 
625                 630                 635                 640 


Ala Gly Lys Thr Pro Leu Cys Asn Leu Leu Val Lys Asp Ser Lys Pro 
                645                 650                 655     


His Phe Thr Thr Val Phe Gln Asn Ser Val Tyr Lys Val Leu Glu Val 
            660                 665                 670         


Val Lys Glu 
        675 


<210>  4058
<211>  782
<212>  PRT
<213>  Homo sapiens

<400>  4058

Met Glu Val Arg Lys Leu Ser Ile Ser Trp Gln Phe Leu Ile Val Leu 
1               5                   10                  15      


Val Leu Ile Leu Gln Ile Leu Ser Ala Leu Asp Phe Asp Pro Tyr Arg 
            20                  25                  30          


Val Leu Gly Val Ser Arg Thr Ala Ser Gln Ala Asp Ile Lys Lys Ala 
        35                  40                  45              


Tyr Lys Lys Leu Ala Arg Glu Trp His Pro Asp Lys Asn Lys Asp Pro 
    50                  55                  60                  


Gly Ala Glu Asp Lys Phe Ile Gln Ile Ser Lys Ala Tyr Glu Ile Leu 
65                  70                  75                  80  


Ser Asn Glu Glu Lys Arg Ser Asn Tyr Asp Gln Tyr Gly Asp Ala Gly 
                85                  90                  95      


Glu Asn Gln Gly Tyr Gln Lys Gln Gln Gln Gln Arg Glu Tyr Arg Phe 
            100                 105                 110         


Arg His Phe His Glu Asn Phe Tyr Phe Asp Glu Ser Phe Phe His Phe 
        115                 120                 125             


Pro Phe Asn Ser Glu Arg Arg Asp Ser Ile Asp Glu Lys Tyr Leu Leu 
    130                 135                 140                 


His Phe Ser His Tyr Val Asn Glu Val Val Pro Asp Ser Phe Lys Lys 
145                 150                 155                 160 


Pro Tyr Leu Ile Lys Ile Thr Ser Asp Trp Cys Phe Ser Cys Ile His 
                165                 170                 175     


Ile Glu Pro Val Trp Lys Glu Val Ile Gln Glu Leu Glu Glu Leu Gly 
            180                 185                 190         


Val Gly Ile Gly Val Val His Ala Gly Tyr Glu Arg Arg Leu Ala His 
        195                 200                 205             


His Leu Gly Ala His Ser Thr Pro Ser Ile Leu Gly Ile Ile Asn Gly 
    210                 215                 220                 


Lys Ile Ser Phe Phe His Asn Ala Val Val Arg Glu Asn Leu Arg Gln 
225                 230                 235                 240 


Phe Val Glu Ser Leu Leu Pro Gly Asn Leu Val Glu Lys Val Thr Asn 
                245                 250                 255     


Lys Asn Tyr Val Arg Phe Leu Ser Gly Trp Gln Gln Glu Asn Lys Pro 
            260                 265                 270         


His Val Leu Leu Phe Asp Gln Thr Pro Ile Val Pro Leu Leu Tyr Lys 
        275                 280                 285             


Leu Thr Ala Phe Ala Tyr Lys Asp Tyr Leu Ser Phe Gly Tyr Val Tyr 
    290                 295                 300                 


Val Gly Leu Arg Gly Thr Glu Glu Met Thr Arg Arg Tyr Asn Ile Asn 
305                 310                 315                 320 


Ile Tyr Ala Pro Thr Leu Leu Val Phe Lys Glu His Ile Asn Arg Pro 
                325                 330                 335     


Ala Asp Val Ile Gln Ala Arg Gly Met Lys Lys Gln Ile Ile Asp Asp 
            340                 345                 350         


Phe Ile Thr Arg Asn Lys Tyr Leu Leu Ala Ala Arg Leu Thr Ser Gln 
        355                 360                 365             


Lys Leu Phe His Glu Leu Cys Pro Val Lys Arg Ser His Arg Gln Arg 
    370                 375                 380                 


Lys Tyr Cys Val Val Leu Leu Thr Ala Glu Thr Thr Lys Leu Ser Lys 
385                 390                 395                 400 


Pro Phe Glu Ala Phe Leu Ser Phe Ala Leu Ala Asn Thr Gln Asp Thr 
                405                 410                 415     


Val Arg Phe Val His Val Tyr Ser Asn Arg Gln Gln Glu Phe Ala Asp 
            420                 425                 430         


Thr Leu Leu Pro Asp Ser Glu Ala Phe Gln Gly Lys Ser Ala Val Ser 
        435                 440                 445             


Ile Leu Glu Arg Arg Asn Thr Ala Gly Arg Val Val Tyr Lys Thr Leu 
    450                 455                 460                 


Glu Asp Pro Trp Ile Gly Ser Glu Ser Asp Lys Phe Ile Leu Leu Gly 
465                 470                 475                 480 


Tyr Leu Asp Gln Leu Arg Lys Asp Pro Ala Leu Leu Ser Ser Glu Ala 
                485                 490                 495     


Val Leu Pro Asp Leu Thr Asp Glu Leu Ala Pro Val Phe Leu Leu Arg 
            500                 505                 510         


Trp Phe Tyr Ser Ala Ser Asp Tyr Ile Ser Asp Cys Trp Asp Ser Ile 
        515                 520                 525             


Phe His Asn Asn Trp Arg Glu Met Met Pro Leu Leu Ser Leu Ile Phe 
    530                 535                 540                 


Ser Ala Leu Phe Ile Leu Phe Gly Thr Val Ile Val Gln Ala Phe Ser 
545                 550                 555                 560 


Asp Ser Asn Asp Glu Arg Glu Ser Ser Pro Pro Glu Lys Glu Glu Ala 
                565                 570                 575     


Gln Glu Lys Thr Gly Lys Thr Glu Pro Ser Phe Thr Lys Glu Asn Ser 
            580                 585                 590         


Ser Lys Ile Pro Lys Lys Gly Phe Val Glu Val Thr Glu Leu Thr Asp 
        595                 600                 605             


Val Thr Tyr Thr Ser Asn Leu Val Arg Leu Arg Pro Gly His Met Asn 
    610                 615                 620                 


Val Val Leu Ile Leu Ser Asn Ser Thr Lys Thr Ser Leu Leu Gln Lys 
625                 630                 635                 640 


Phe Ala Leu Glu Val Tyr Thr Phe Thr Gly Ser Ser Cys Leu His Phe 
                645                 650                 655     


Ser Phe Leu Ser Leu Asp Lys His Arg Glu Trp Leu Glu Tyr Leu Leu 
            660                 665                 670         


Glu Phe Ala Gln Asp Ala Ala Pro Ile Pro Asn Gln Tyr Asp Lys His 
        675                 680                 685             


Phe Met Glu Arg Asp Tyr Thr Gly Tyr Val Leu Ala Leu Asn Gly His 
    690                 695                 700                 


Lys Lys Tyr Phe Cys Leu Phe Lys Pro Gln Lys Thr Val Glu Glu Glu 
705                 710                 715                 720 


Glu Ala Ile Gly Ser Cys Ser Asp Val Asp Ser Ser Leu Tyr Leu Gly 
                725                 730                 735     


Glu Ser Arg Gly Lys Pro Ser Cys Gly Leu Gly Ser Arg Pro Ile Lys 
            740                 745                 750         


Gly Lys Leu Ser Lys Leu Ser Leu Trp Met Glu Arg Leu Leu Glu Gly 
        755                 760                 765             


Ser Leu Gln Arg Phe Tyr Ile Pro Ser Trp Pro Glu Leu Asp 
    770                 775                 780         


<210>  4059
<211>  1104
<212>  PRT
<213>  Homo sapiens

<400>  4059

Met Glu Arg Ser Pro Gly Glu Gly Pro Ser Pro Ser Pro Met Asp Gln 
1               5                   10                  15      


Pro Ser Ala Pro Ser Asp Pro Thr Asp Gln Pro Pro Ala Ala His Ala 
            20                  25                  30          


Lys Pro Asp Pro Gly Ser Gly Gly Gln Pro Ala Gly Pro Gly Ala Ala 
        35                  40                  45              


Gly Glu Ala Leu Ala Val Leu Thr Ser Phe Gly Arg Arg Leu Leu Val 
    50                  55                  60                  


Leu Ile Pro Val Tyr Leu Ala Gly Ala Val Gly Leu Ser Val Gly Phe 
65                  70                  75                  80  


Val Leu Phe Gly Leu Ala Leu Tyr Leu Gly Trp Arg Arg Val Arg Asp 
                85                  90                  95      


Glu Lys Glu Arg Ser Leu Arg Ala Ala Arg Gln Leu Leu Asp Asp Glu 
            100                 105                 110         


Glu Gln Leu Thr Ala Lys Thr Leu Tyr Met Ser His Arg Glu Leu Pro 
        115                 120                 125             


Ala Trp Val Ser Phe Pro Asp Val Glu Lys Ala Glu Trp Leu Asn Lys 
    130                 135                 140                 


Ile Val Ala Gln Val Trp Pro Phe Leu Gly Gln Tyr Met Glu Lys Leu 
145                 150                 155                 160 


Leu Ala Glu Thr Val Ala Pro Ala Val Arg Gly Ser Asn Pro His Leu 
                165                 170                 175     


Gln Thr Phe Thr Phe Thr Arg Val Glu Leu Gly Glu Lys Pro Leu Arg 
            180                 185                 190         


Ile Ile Gly Val Lys Val His Pro Gly Gln Arg Lys Glu Gln Ile Leu 
        195                 200                 205             


Leu Asp Leu Asn Ile Ser Tyr Val Gly Asp Val Gln Ile Asp Val Glu 
    210                 215                 220                 


Val Lys Lys Tyr Phe Cys Lys Ala Gly Val Lys Gly Met Gln Leu His 
225                 230                 235                 240 


Gly Val Leu Arg Val Ile Leu Glu Pro Leu Ile Gly Asp Leu Pro Phe 
                245                 250                 255     


Val Gly Ala Val Ser Met Phe Phe Ile Arg Arg Pro Thr Leu Asp Ile 
            260                 265                 270         


Asn Trp Thr Gly Met Thr Asn Leu Leu Asp Ile Pro Gly Leu Ser Ser 
        275                 280                 285             


Leu Ser Asp Thr Met Ile Met Asp Ser Ile Ala Ala Phe Leu Val Leu 
    290                 295                 300                 


Pro Asn Arg Leu Leu Val Pro Leu Val Pro Asp Leu Gln Asp Val Ala 
305                 310                 315                 320 


Gln Leu Arg Ser Pro Leu Pro Arg Gly Ile Ile Arg Ile His Leu Leu 
                325                 330                 335     


Ala Ala Arg Gly Leu Ser Ser Lys Asp Lys Tyr Val Lys Gly Leu Ile 
            340                 345                 350         


Glu Gly Lys Ser Asp Pro Tyr Ala Leu Val Arg Leu Gly Thr Gln Thr 
        355                 360                 365             


Phe Cys Ser Arg Val Ile Asp Glu Glu Leu Asn Pro Gln Trp Gly Glu 
    370                 375                 380                 


Thr Tyr Glu Val Met Val His Glu Val Pro Gly Gln Glu Ile Glu Val 
385                 390                 395                 400 


Glu Val Phe Asp Lys Asp Pro Asp Lys Asp Asp Phe Leu Gly Arg Met 
                405                 410                 415     


Lys Leu Asp Val Gly Lys Val Leu Gln Ala Ser Val Leu Asp Asp Trp 
            420                 425                 430         


Phe Pro Leu Gln Gly Gly Gln Gly Gln Val His Leu Arg Leu Glu Trp 
        435                 440                 445             


Leu Ser Leu Leu Ser Asp Ala Glu Lys Leu Glu Gln Val Leu Gln Trp 
    450                 455                 460                 


Asn Trp Gly Val Ser Ser Arg Pro Asp Pro Pro Ser Ala Ala Ile Leu 
465                 470                 475                 480 


Val Val Tyr Leu Asp Arg Ala Gln Asp Leu Pro Leu Lys Lys Gly Asn 
                485                 490                 495     


Lys Glu Pro Asn Pro Met Val Gln Leu Ser Ile Gln Asp Val Thr Gln 
            500                 505                 510         


Glu Ser Lys Ala Val Tyr Ser Thr Asn Cys Pro Val Trp Glu Glu Ala 
        515                 520                 525             


Phe Arg Phe Phe Leu Gln Asp Pro Gln Ser Gln Glu Leu Asp Val Gln 
    530                 535                 540                 


Val Lys Asp Asp Ser Arg Ala Leu Thr Leu Gly Ala Leu Thr Leu Pro 
545                 550                 555                 560 


Leu Ala Arg Leu Leu Thr Ala Pro Glu Leu Ile Leu Asp Gln Trp Phe 
                565                 570                 575     


Gln Leu Ser Ser Ser Gly Pro Asn Ser Arg Leu Tyr Met Lys Leu Val 
            580                 585                 590         


Met Arg Ile Leu Tyr Leu Asp Ser Ser Glu Ile Cys Phe Pro Thr Val 
        595                 600                 605             


Pro Gly Cys Pro Gly Ala Trp Asp Val Asp Ser Glu Asn Pro Gln Arg 
    610                 615                 620                 


Gly Ser Ser Val Asp Ala Pro Pro Arg Pro Cys His Thr Thr Pro Asp 
625                 630                 635                 640 


Ser Gln Phe Gly Thr Glu His Val Leu Arg Ile His Val Leu Glu Ala 
                645                 650                 655     


Gln Asp Leu Ile Ala Lys Asp Arg Phe Leu Gly Gly Leu Val Lys Gly 
            660                 665                 670         


Lys Ser Asp Pro Tyr Val Lys Leu Lys Leu Ala Gly Arg Ser Phe Arg 
        675                 680                 685             


Ser His Val Val Arg Glu Asp Leu Asn Pro Arg Trp Asn Glu Val Phe 
    690                 695                 700                 


Glu Val Ile Val Thr Ser Val Pro Gly Gln Glu Leu Glu Val Glu Val 
705                 710                 715                 720 


Phe Asp Lys Asp Leu Asp Lys Asp Asp Phe Leu Gly Arg Cys Lys Val 
                725                 730                 735     


Arg Leu Thr Thr Val Leu Asn Ser Gly Phe Leu Asp Glu Trp Leu Thr 
            740                 745                 750         


Leu Glu Asp Val Pro Ser Gly Arg Leu His Leu Arg Leu Glu Arg Leu 
        755                 760                 765             


Thr Pro Arg Pro Thr Ala Ala Glu Leu Glu Glu Val Leu Gln Val Asn 
    770                 775                 780                 


Ser Leu Ile Gln Thr Gln Lys Ser Ala Glu Leu Ala Ala Ala Leu Leu 
785                 790                 795                 800 


Ser Ile Tyr Met Glu Arg Ala Glu Asp Leu Pro Leu Arg Lys Gly Thr 
                805                 810                 815     


Lys His Leu Ser Pro Tyr Ala Thr Leu Thr Val Gly Asp Ser Ser His 
            820                 825                 830         


Lys Thr Lys Thr Ile Ser Gln Thr Ser Ala Pro Val Trp Asp Glu Ser 
        835                 840                 845             


Ala Ser Phe Leu Ile Arg Lys Pro His Thr Glu Ser Leu Glu Leu Gln 
    850                 855                 860                 


Val Arg Gly Glu Gly Thr Gly Val Leu Gly Ser Leu Ser Leu Pro Leu 
865                 870                 875                 880 


Ser Glu Leu Leu Val Ala Asp Gln Leu Cys Leu Asp Arg Trp Phe Thr 
                885                 890                 895     


Leu Ser Ser Gly Gln Gly Gln Val Leu Leu Arg Ala Gln Leu Gly Ile 
            900                 905                 910         


Leu Val Ser Gln His Ser Gly Val Glu Ala His Ser His Ser Tyr Ser 
        915                 920                 925             


His Ser Ser Ser Ser Leu Ser Glu Glu Pro Glu Leu Ser Gly Gly Pro 
    930                 935                 940                 


Pro His Ile Thr Ser Ser Ala Pro Glu Leu Arg Gln Arg Leu Thr His 
945                 950                 955                 960 


Val Asp Ser Pro Leu Glu Ala Pro Ala Gly Pro Leu Gly Gln Val Lys 
                965                 970                 975     


Leu Thr Leu Trp Tyr Tyr Ser Glu Glu Arg Lys Leu Val Ser Ile Val 
            980                 985                 990         


His Gly Cys Arg Ser Leu Arg Gln  Asn Gly Arg Asp Pro  Pro Asp Pro 
        995                 1000                 1005             


Tyr Val  Ser Leu Leu Leu Leu  Pro Asp Lys Asn Arg  Gly Thr Lys 
    1010                 1015                 1020             


Arg Arg  Thr Ser Gln Lys Lys  Arg Thr Leu Ser Pro  Glu Phe Asn 
    1025                 1030                 1035             


Glu Arg  Phe Glu Trp Glu Leu  Pro Leu Asp Glu Ala  Gln Arg Arg 
    1040                 1045                 1050             


Lys Leu  Asp Val Ser Val Lys  Ser Asn Ser Ser Phe  Met Ser Arg 
    1055                 1060                 1065             


Glu Arg  Glu Leu Leu Gly Lys  Val Gln Leu Asp Leu  Ala Glu Thr 
    1070                 1075                 1080             


Asp Leu  Ser Gln Gly Val Ala  Arg Trp Tyr Asp Leu  Met Asp Asn 
    1085                 1090                 1095             


Lys Asp  Lys Gly Ser Ser 
    1100                 


<210>  4060
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  4060

Met Pro Pro Ala Gly Gly Pro Arg Ala Pro Arg Pro Ala Ala Leu Pro 
1               5                   10                  15      


Arg Ser Leu Ser Arg Leu Arg Glu Cys Pro Gly Arg Ser Arg Ile Val 
            20                  25                  30          


Leu Ala Leu Gly Ala Thr Gln Met Ala Leu Gly Cys Leu Ile Val Ala 
        35                  40                  45              


Val Ser Phe Ala Ala Leu Ala Leu Thr Thr Ser Ala Arg Val Arg His 
    50                  55                  60                  


Ser Cys Pro Phe Trp Ala Gly Phe Ser Val Leu Leu Ser Gly Leu Ile 
65                  70                  75                  80  


Gly Val Val Ser Trp Lys Arg Pro Leu Ser Leu Val Ile Thr Phe Phe 
                85                  90                  95      


Met Leu Leu Ser Ala Val Cys Val Met Leu Asn Leu Ala Gly Ser Ile 
            100                 105                 110         


Leu Ser Cys Gln Asn Ala Gln Leu Val Asn Ser Leu Glu Gly Cys Gln 
        115                 120                 125             


Leu Ile Lys Phe Asp Ser Val Glu Val Cys Val Cys Cys Glu Leu Gln 
    130                 135                 140                 


His Gln Ser Ser Gly Cys Ser Asn Leu Gly Glu Thr Leu Lys Leu Asn 
145                 150                 155                 160 


Pro Leu Gln Glu Asn Cys Asn Ala Val Arg Leu Thr Leu Lys Asp Leu 
                165                 170                 175     


Leu Phe Ser Val Cys Ala Leu Asn Val Leu Ser Thr Ile Val Cys Ala 
            180                 185                 190         


Leu Ala Thr Ala Met Cys Cys Met Gln Met Val Ser Ser Asp Val Leu 
        195                 200                 205             


Gln Met Phe Leu Pro Gln Arg Ser His Pro Ala Asn Pro Thr Cys Val 
    210                 215                 220                 


Thr Pro His Gly Thr Val Leu His Gln Thr Leu Asp Phe Asp Glu Phe 
225                 230                 235                 240 


Ile Pro Pro Leu Pro Pro Pro Pro Tyr Tyr Pro Pro Glu Tyr Thr Cys 
                245                 250                 255     


Thr Pro Ser Thr Glu Ala Gln Arg Gly Leu His Leu Asp Phe Ala Pro 
            260                 265                 270         


Ser Pro Phe Gly Thr Leu Tyr Asp Val Ala Ile Asn Ser Pro Gly Leu 
        275                 280                 285             


Leu Tyr Pro Ala Glu Leu Pro Pro Pro Tyr Glu Ala Val Val Gly Gln 
    290                 295                 300                 


Pro Pro Ala Ser Gln Val Thr Ser Ile Gly Gln Gln Val Ala Glu Ser 
305                 310                 315                 320 


Ser Ser Gly Asp Pro Asn Thr Ser Ala Gly Phe Ser Thr Pro Val Pro 
                325                 330                 335     


Ala Asp Ser Thr Ser Leu Leu Val Ser Glu Gly Thr Ala Thr Pro Gly 
            340                 345                 350         


Ser Ser Pro Ser Pro Asp Gly Pro Val Gly Ala Pro Ala Pro Ser Glu 
        355                 360                 365             


Pro Ala Leu Pro Pro Gly His Val Ser Pro Glu Asp Pro Gly Met Gly 
    370                 375                 380                 


Ser Gln Val Gln Pro Gly Pro Gly Arg Val Ser Arg Ser Thr Ser Asp 
385                 390                 395                 400 


Pro Thr Leu Cys Thr Ser Ser Met Ala Gly Asp Ala Ser Ser His Arg 
                405                 410                 415     


Pro Ser Cys Ser Gln Asp Leu Glu Ala Gly Leu Ser Glu Ala Val Pro 
            420                 425                 430         


Gly Ser Ala Ser Met Ser Arg Ser Ala Thr Ala Ala Cys Arg Ala Gln 
        435                 440                 445             


Leu Ser Pro Ala Gly Asp Pro Asp Thr Trp Lys Thr Asp Gln Arg Pro 
    450                 455                 460                 


Thr Pro Glu Pro Phe Pro Ala Thr Ser Lys Glu Arg Pro Arg Ser Leu 
465                 470                 475                 480 


Val Asp Ser Lys Ala Tyr Ala Asp Ala Arg Val Leu Val Ala Lys Phe 
                485                 490                 495     


Leu Glu His Ser His Cys Ala Leu Pro Thr Glu Ala Gln His Met Val 
            500                 505                 510         


Gly Ala Met Arg Leu Ala Val Thr Asn Glu Glu Arg Leu Glu Glu Glu 
        515                 520                 525             


Ala Val Phe Gly Ala Asp Val Leu Asp Gln Val 
    530                 535                 


<210>  4061
<211>  5005
<212>  PRT
<213>  Homo sapiens

<400>  4061

Met Asp Gln Arg Lys Asn Glu Ser Ile Val Pro Ser Ile Thr Gln Leu 
1               5                   10                  15      


Glu Asp Phe Leu Thr Glu His Asn Ser Asn Val Val Trp Leu Leu Val 
            20                  25                  30          


Ala Thr Ile Leu Ser Cys Gly Trp Ile Ile Tyr Leu Thr Tyr Tyr Asn 
        35                  40                  45              


Ser Arg Asn Val Gly Leu Ile Leu Thr Leu Val Leu Asn Arg Leu Tyr 
    50                  55                  60                  


Lys His Gly Tyr Ile His Ile Gly Ser Phe Ser Phe Ser Val Leu Ser 
65                  70                  75                  80  


Gly Lys Val Met Val Arg Glu Ile Tyr Tyr Ile Thr Glu Asp Met Ser 
                85                  90                  95      


Ile Arg Ile Gln Asp Gly Phe Ile Ile Phe Arg Trp Trp Lys Met Tyr 
            100                 105                 110         


Asn Pro Lys Gln Lys Gln His Asp Pro Lys Ala Glu Thr Arg Leu Tyr 
        115                 120                 125             


Ile Thr Val Asn Asp Phe Glu Phe His Val Tyr Asn Arg Ser Asp Leu 
    130                 135                 140                 


Tyr Gly Arg Leu Gln Glu Leu Phe Gly Leu Glu Pro Thr Ile Ile Pro 
145                 150                 155                 160 


Pro Lys Lys Asp Asp Asp Lys Thr Arg Glu Ile Gly Arg Thr Arg Thr 
                165                 170                 175     


Gln Ser Lys Ile Glu Arg Val Lys Val Lys Thr Glu Ser Gln Asp Pro 
            180                 185                 190         


Thr Ser Ser Trp Arg Ser Leu Ile Pro Val Ile Lys Val Asn Val Ser 
        195                 200                 205             


Thr Gly Arg Leu Ala Phe Gly Asn His Tyr Gln Pro Gln Thr Leu Cys 
    210                 215                 220                 


Ile Asn Phe Asp Asp Ala Phe Leu Thr Tyr Thr Thr Lys Pro Pro Ser 
225                 230                 235                 240 


Ser His Leu Asp Gln Phe Met His Ile Val Lys Gly Lys Leu Glu Asn 
                245                 250                 255     


Val Arg Val Met Leu Val Pro Ser Pro Arg Tyr Val Gly Leu Gln Asn 
            260                 265                 270         


Asp Glu Pro Pro Arg Leu Met Gly Glu Gly Phe Val Val Met Gln Ser 
        275                 280                 285             


Asn Asp Val Asp Ile Tyr Tyr Tyr Met Asp Glu Pro Gly Leu Val Pro 
    290                 295                 300                 


Glu Glu Thr Glu Glu Asn Ile Glu Gly Glu Met Ser Ser Glu Asp Cys 
305                 310                 315                 320 


Lys Leu Gln Asp Leu Pro Pro Cys Trp Gly Leu Asp Ile Val Cys Gly 
                325                 330                 335     


Lys Gly Thr Asp Phe Asn Tyr Gly Pro Trp Ala Asp Arg Gln Arg Asp 
            340                 345                 350         


Cys Leu Trp Lys Phe Phe Phe Pro Pro Asp Tyr Gln Val Leu Lys Val 
        355                 360                 365             


Ser Glu Ile Ala Gln Pro Gly Arg Pro Arg Gln Ile Leu Ala Phe Glu 
    370                 375                 380                 


Leu Arg Met Asn Ile Ile Ala Asp Ala Thr Ile Asp Leu Leu Phe Thr 
385                 390                 395                 400 


Lys Asn Arg Glu Thr Asn Ala Val His Val Asn Val Gly Ala Gly Ser 
                405                 410                 415     


Tyr Leu Glu Ile Asn Ile Pro Met Thr Val Glu Glu Asn Gly Tyr Thr 
            420                 425                 430         


Pro Ala Ile Lys Gly Gln Leu Leu His Val Asp Ala Thr Thr Ser Met 
        435                 440                 445             


Gln Tyr Arg Thr Leu Leu Glu Ala Glu Met Leu Ala Phe His Ile Asn 
    450                 455                 460                 


Ala Ser Tyr Pro Arg Ile Trp Asn Met Pro Gln Thr Trp Gln Cys Glu 
465                 470                 475                 480 


Leu Glu Val Tyr Lys Ala Thr Tyr His Phe Ile Phe Ala Gln Lys Asn 
                485                 490                 495     


Phe Phe Thr Asp Leu Ile Gln Asp Trp Ser Ser Asp Ser Pro Pro Asp 
            500                 505                 510         


Ile Phe Ser Phe Val Pro Tyr Thr Trp Asn Phe Lys Ile Met Phe His 
        515                 520                 525             


Gln Phe Glu Met Ile Trp Ala Ala Asn Gln His Asn Trp Ile Asp Cys 
    530                 535                 540                 


Ser Thr Lys Gln Gln Glu Asn Val Tyr Leu Ala Ala Cys Gly Glu Thr 
545                 550                 555                 560 


Leu Asn Ile Asp Phe Ser Leu Pro Phe Thr Asp Phe Val Pro Ala Thr 
                565                 570                 575     


Cys Asn Thr Lys Phe Ser Leu Arg Gly Glu Asp Val Asp Leu His Leu 
            580                 585                 590         


Phe Leu Pro Asp Cys His Pro Ser Lys Tyr Ser Leu Phe Met Leu Val 
        595                 600                 605             


Lys Asn Cys His Pro Asn Lys Met Ile His Asp Thr Gly Ile Pro Ala 
    610                 615                 620                 


Glu Cys Gln Ser Gly Gln Lys Thr Val Lys Pro Lys Trp Arg Asn Val 
625                 630                 635                 640 


Thr Gln Glu Lys Ser Gly Trp Val Glu Cys Trp Thr Val Pro Ser Val 
                645                 650                 655     


Met Leu Thr Ile Asp Tyr Thr Trp His Pro Ile Tyr Pro Gln Lys Ala 
            660                 665                 670         


Asp Glu Gln Leu Lys Gln Ser Leu Ser Glu Met Glu Glu Thr Met Leu 
        675                 680                 685             


Ser Val Leu Arg Pro Ser Gln Lys Thr Ser Asp Arg Val Val Ser Ser 
    690                 695                 700                 


Pro Ser Thr Ser Ser Arg Pro Pro Ile Asp Pro Ser Glu Leu Pro Pro 
705                 710                 715                 720 


Asp Lys Leu His Val Glu Met Glu Leu Ser Pro Asp Ser Gln Ile Thr 
                725                 730                 735     


Leu Tyr Gly Pro Leu Leu Asn Ala Phe Leu Cys Ile Lys Glu Asn Tyr 
            740                 745                 750         


Phe Gly Glu Asp Asp Met Tyr Met Asp Phe Glu Glu Val Ile Ser Ser 
        755                 760                 765             


Pro Val Leu Ser Leu Ser Thr Ser Ser Ser Ser Gly Trp Thr Ala Val 
    770                 775                 780                 


Gly Met Glu Asn Asp Lys Lys Glu Asn Glu Gly Ser Ala Lys Ser Ile 
785                 790                 795                 800 


His Pro Leu Ala Leu Arg Pro Trp Asp Ile Thr Val Leu Val Asn Leu 
                805                 810                 815     


Tyr Lys Val His Gly Arg Leu Pro Val His Gly Thr Thr Asp Gly Pro 
            820                 825                 830         


Glu Cys Pro Thr Ala Phe Leu Glu Arg Leu Cys Phe Glu Met Lys Lys 
        835                 840                 845             


Gly Phe Arg Glu Thr Met Leu Gln Leu Ile Leu Ser Pro Leu Asn Val 
    850                 855                 860                 


Phe Val Ser Asp Asn Tyr Gln Gln Arg Pro Pro Val Asp Glu Val Leu 
865                 870                 875                 880 


Arg Glu Gly His Ile Asn Leu Ser Gly Leu Gln Leu Arg Ala His Ala 
                885                 890                 895     


Met Phe Ser Ala Glu Gly Leu Pro Leu Gly Ser Asp Ser Leu Glu Tyr 
            900                 905                 910         


Ala Trp Leu Ile Asp Val Gln Ala Gly Ser Leu Thr Ala Lys Val Thr 
        915                 920                 925             


Ala Pro Gln Leu Ala Cys Leu Leu Glu Trp Gly Gln Thr Phe Val Phe 
    930                 935                 940                 


His Val Val Cys Arg Glu Tyr Glu Leu Glu Arg Pro Lys Ser Val Ile 
945                 950                 955                 960 


Ile Cys Gln His Gly Ile Asp Arg Arg Phe Cys Glu Ser Lys Leu Ser 
                965                 970                 975     


Cys Ile Pro Gly Pro Cys Pro Thr Ser Asp Asp Leu Lys Tyr Thr Met 
            980                 985                 990         


Ile Arg Leu Ala Val Asp Gly Ala  Asp Ile Tyr Ile Val  Glu His Gly 
        995                 1000                 1005             


Cys Ala  Thr Asn Ile Lys Met  Gly Ala Ile Arg Val  Ala Asn Cys 
    1010                 1015                 1020             


Asn Leu  His Asn Gln Ser Val  Gly Glu Gly Ile Ser  Ala Ala Ile 
    1025                 1030                 1035             


Gln Asp  Phe Gln Val Arg Gln  Tyr Ile Glu Gln Leu  Asn Asn Cys 
    1040                 1045                 1050             


Arg Ile  Gly Leu Gln Pro Ala  Val Leu Arg Arg Ala  Tyr Trp Leu 
    1055                 1060                 1065             


Glu Ala  Gly Ser Ala Asn Leu  Gly Leu Ile Thr Val  Asp Ile Ala 
    1070                 1075                 1080             


Leu Ala  Ala Asp His His Ser  Lys His Glu Ala Gln  Arg His Phe 
    1085                 1090                 1095             


Leu Glu  Thr His Asp Ala Arg  Thr Lys Arg Leu Trp  Phe Leu Trp 
    1100                 1105                 1110             


Pro Asp  Asp Ile Leu Lys Asn  Lys Arg Cys Arg Asn  Lys Cys Gly 
    1115                 1120                 1125             


Cys Leu  Gly Gly Cys Arg Phe  Phe Gly Gly Thr Val  Thr Gly Leu 
    1130                 1135                 1140             


Asp Phe  Phe Lys Leu Glu Glu  Leu Thr Pro Ser Ser  Ser Ser Ala 
    1145                 1150                 1155             


Phe Ser  Ser Thr Ser Ala Glu  Ser Asp Met Tyr Tyr  Gly Gln Ser 
    1160                 1165                 1170             


Leu Leu  Gln Pro Gly Glu Trp  Ile Ile Thr Lys Glu  Ile Pro Lys 
    1175                 1180                 1185             


Ile Ile  Asp Gly Asn Val Asn  Gly Met Lys Arg Lys  Glu Trp Glu 
    1190                 1195                 1200             


Asn Lys  Ser Val Gly Ile Glu  Val Glu Arg Lys Thr  Gln His Leu 
    1205                 1210                 1215             


Ser Leu  Gln Val Pro Leu Arg  Ser His Ser Ser Ser  Ser Ser Ser 
    1220                 1225                 1230             


Glu Glu  Asn Ser Ser Ser Ser  Ala Ala Gln Pro Leu  Leu Ala Gly 
    1235                 1240                 1245             


Glu Lys  Glu Ser Pro Ser Ser  Val Ala Asp Asp His  Leu Val Gln 
    1250                 1255                 1260             


Lys Glu  Phe Leu His Gly Thr  Lys Arg Asp Asp Gly  Gln Ala Ser 
    1265                 1270                 1275             


Ile Pro  Thr Glu Ile Ser Gly  Asn Ser Pro Val Ser  Pro Asn Thr 
    1280                 1285                 1290             


Gln Asp  Lys Ser Val Gly Gln  Ser Pro Leu Arg Ser  Pro Leu Lys 
    1295                 1300                 1305             


Arg Gln  Ala Ser Val Cys Ser  Thr Arg Leu Gly Ser  Thr Lys Ser 
    1310                 1315                 1320             


Leu Thr  Ala Ala Phe Tyr Gly  Asp Lys Gln Pro Val  Thr Val Gly 
    1325                 1330                 1335             


Val Gln  Phe Ser Ser Asp Val  Ser Arg Ser Asp Glu  Asn Val Leu 
    1340                 1345                 1350             


Asp Ser  Pro Lys Gln Arg Arg  Ser Phe Gly Ser Phe  Pro Tyr Thr 
    1355                 1360                 1365             


Pro Ser  Ala Asp Ser Asn Ser  Phe His Gln Tyr Arg  Ser Met Asp 
    1370                 1375                 1380             


Ser Ser  Met Ser Met Ala Asp  Ser Glu Ala Tyr Phe  Ser Ala Ala 
    1385                 1390                 1395             


Glu Glu  Phe Glu Pro Ile Ser  Ser Asp Glu Gly Pro  Gly Thr Tyr 
    1400                 1405                 1410             


Pro Gly  Arg Lys Lys Lys Lys  Lys Gln Thr Gln Gln  Ile Asp Tyr 
    1415                 1420                 1425             


Ser Arg  Gly Ser Ile Tyr His  Ser Val Glu Gly Pro  Leu Thr Gly 
    1430                 1435                 1440             


His Gly  Glu Ser Ile Gln Asp  Ser Arg Thr Leu Pro  Phe Lys Thr 
    1445                 1450                 1455             


His Pro  Ser Gln Ala Ser Phe  Val Ser Ala Leu Gly  Gly Glu Asp 
    1460                 1465                 1470             


Asp Val  Ile Glu His Leu Tyr  Ile Val Glu Gly Glu  Lys Thr Val 
    1475                 1480                 1485             


Glu Ser  Glu Gln Ile Thr Pro  Gln Gln Pro Val Met  Asn Cys Tyr 
    1490                 1495                 1500             


Gln Thr  Tyr Leu Thr Gln Phe  Gln Val Ile Asn Trp  Ser Val Lys 
    1505                 1510                 1515             


His Pro  Thr Asn Lys Arg Thr  Ser Lys Ser Ser Leu  His Arg Pro 
    1520                 1525                 1530             


Leu Asp  Leu Asp Thr Pro Thr  Ser Glu Glu Ser Ser  Ser Ser Phe 
    1535                 1540                 1545             


Glu Gln  Leu Ser Val Pro Thr  Phe Lys Val Ile Lys  Gln Gly Leu 
    1550                 1555                 1560             


Thr Ala  Asn Ser Leu Leu Asp  Arg Gly Met Gln Leu  Ser Gly Ser 
    1565                 1570                 1575             


Thr Ser  Asn Thr Pro Tyr Thr  Pro Leu Glu Lys Lys  Leu Ala Asp 
    1580                 1585                 1590             


Asn Thr  Asp Asp Glu Thr Leu  Thr Glu Glu Trp Thr  Leu Asp Gln 
    1595                 1600                 1605             


Pro Val  Ser Gln Thr Arg Thr  Thr Ala Ile Val Glu  Val Lys Gly 
    1610                 1615                 1620             


Thr Val  Asp Ile Val Leu Thr  Pro Leu Val Ala Glu  Ala Leu Asp 
    1625                 1630                 1635             


Arg Tyr  Ile Glu Ala Met Val  His Cys Ala Ser Thr  Arg His Pro 
    1640                 1645                 1650             


Ala Ala  Ile Val Asp Asp Leu  His Ala Lys Val Leu  Arg Glu Ala 
    1655                 1660                 1665             


Val Gln  Asn Ser Lys Thr Thr  Phe Ser Glu Asn Leu  Ser Ser Lys 
    1670                 1675                 1680             


Gln Asp  Ile Arg Gly Thr Lys  Thr Glu Gln Ser Thr  Ile Gly Thr 
    1685                 1690                 1695             


Thr Asn  Gln Gly Gln Ala Gln  Thr Asn Leu Thr Met  Lys Gln Asp 
    1700                 1705                 1710             


Asn Val  Thr Ile Lys Gly Leu  Gln Thr Asn Val Ser  Ile Pro Lys 
    1715                 1720                 1725             


Val Asn  Leu Cys Leu Leu Gln  Ala Ser Val Glu Glu  Ser Pro Thr 
    1730                 1735                 1740             


Thr Ala  Pro Ser Arg Ser Val  Thr His Val Ser Leu  Val Ala Leu 
    1745                 1750                 1755             


Cys Phe  Asp Arg Ile Ala Thr  Gln Val Arg Met Asn  Arg Gly Val 
    1760                 1765                 1770             


Val Glu  Glu Thr Ser Asn Asn  Ala Glu Pro Gly Arg  Thr Ser Asn 
    1775                 1780                 1785             


Phe Asp  Arg Tyr Val His Ala  Thr Lys Met Gln Pro  Gln Ser Ser 
    1790                 1795                 1800             


Gly Ser  Leu Arg Ser Asn Ala  Gly Ala Glu Lys Gly  Lys Glu Ile 
    1805                 1810                 1815             


Ala Ala  Lys Leu Asn Ile His  Arg Val His Gly Gln  Leu Arg Gly 
    1820                 1825                 1830             


Leu Asp  Thr Thr Asp Ile Gly  Thr Cys Ala Ile Thr  Ala Ile Pro 
    1835                 1840                 1845             


Phe Glu  Lys Ser Lys Val Leu  Phe Thr Leu Glu Glu  Leu Asp Glu 
    1850                 1855                 1860             


Phe Thr  Phe Val Asp Glu Thr  Asp Gln Gln Ala Val  Pro Asp Val 
    1865                 1870                 1875             


Thr Arg  Ile Gly Pro Ser Gln  Glu Lys Trp Gly Trp  Ile Met Phe 
    1880                 1885                 1890             


Glu Cys  Gly Leu Glu Asn Leu  Thr Ile Lys Gly Gly  Arg Gln Ser 
    1895                 1900                 1905             


Gly Ala  Val Leu Tyr Asn Ser  Phe Gly Ile Met Gly  Lys Ala Ser 
    1910                 1915                 1920             


Asp Thr  Glu Arg Gly Gly Val  Leu Thr Ser Asn Asn  Ser Ser Asp 
    1925                 1930                 1935             


Ser Pro  Thr Gly Ser Gly Tyr  Asn Thr Asp Val Ser  Asp Asp Asn 
    1940                 1945                 1950             


Leu Pro  Cys Asp Arg Thr Ser  Pro Ser Ser Asp Leu  Asn Gly Asn 
    1955                 1960                 1965             


Ser Val  Ser Asp Glu Gln Asp  Glu Gly Val Glu Ser  Asp Asp Leu 
    1970                 1975                 1980             


Lys Lys  Asp Leu Pro Leu Met  Pro Pro Pro Pro Asp  Ser Cys Ser 
    1985                 1990                 1995             


Met Lys  Leu Thr Ile Lys Glu  Ile Trp Phe Ser Phe  Ala Ala Pro 
    2000                 2005                 2010             


Thr Asn  Val Arg Ser His Thr  His Ala Phe Ser Arg  Gln Leu Asn 
    2015                 2020                 2025             


Leu Leu  Ser Thr Ala Thr Pro  Ala Val Gly Ala Trp  Leu Val Pro 
    2030                 2035                 2040             


Ile Asp  Gln Leu Lys Ser Ser  Leu Asn Lys Leu Glu  Thr Glu Gly 
    2045                 2050                 2055             


Thr Leu  Arg Ile Cys Ala Val  Met Gly Cys Ile Met  Thr Glu Ala 
    2060                 2065                 2070             


Leu Glu  Asn Lys Ser Val His  Phe Pro Leu Arg Ser  Lys Tyr Asn 
    2075                 2080                 2085             


Arg Leu  Thr Lys Val Ala Arg  Phe Leu Gln Glu Asn  Pro Ser Cys 
    2090                 2095                 2100             


Leu Leu  Cys Asn Ile Leu His  His Tyr Leu His Gln  Ala Asn Tyr 
    2105                 2110                 2115             


Ser Ile  Ile Asp Asp Ala Thr  Met Ser Asp Gly Leu  Pro Ala Leu 
    2120                 2125                 2130             


Val Thr  Leu Lys Lys Gly Leu  Val Ala Leu Ala Arg  Gln Trp Met 
    2135                 2140                 2145             


Lys Phe  Ile Val Val Thr Pro  Ala Phe Lys Gly Val  Ser Leu His 
    2150                 2155                 2160             


Arg Pro  Ala Gln Pro Leu Lys  Pro Gln Ile Ala Met  Asp His Glu 
    2165                 2170                 2175             


His Glu  Asp Gly Leu Gly Leu  Asp Asn Gly Gly Gly  Leu Gln Ser 
    2180                 2185                 2190             


Asp Thr  Ser Ala Asp Gly Ala  Glu Phe Glu Phe Asp  Ala Ala Thr 
    2195                 2200                 2205             


Val Ser  Glu His Thr Met Leu  Leu Glu Gly Thr Ala  Asn Arg Pro 
    2210                 2215                 2220             


Pro Pro  Gly Ser Ser Gly Pro  Val Thr Gly Ala Glu  Ile Met Arg 
    2225                 2230                 2235             


Lys Leu  Ser Lys Thr His Thr  His Ser Asp Ser Ala  Leu Lys Ile 
    2240                 2245                 2250             


Lys Gly  Ile His Pro Tyr His  Ser Leu Ser Tyr Thr  Ser Gly Asp 
    2255                 2260                 2265             


Thr Ala  Thr Asp Ser Pro Val  His Val Gly Arg Ala  Gly Met Pro 
    2270                 2275                 2280             


Val Lys  Asp Ser Pro Arg Lys  Glu Ser Leu Leu Ser  Tyr Leu Thr 
    2285                 2290                 2295             


Gly Ser  Phe Pro Ser Leu His  Asn Leu Leu Glu Gly  Thr Pro Gln 
    2300                 2305                 2310             


Arg Ser  Ser Ala Ala Val Lys  Ser Ser Ser Leu Thr  Arg Thr Gly 
    2315                 2320                 2325             


Asn Thr  Val Ala Thr Asp Met  Leu Ser Glu His Pro  Leu Leu Ser 
    2330                 2335                 2340             


Glu Pro  Ser Ser Val Ser Phe  Tyr Asn Trp Met Ser  Asn Ala Val 
    2345                 2350                 2355             


Gly Asn  Arg Gly Ser Val Leu  Gln Glu Ser Pro Val  Thr Lys Ser 
    2360                 2365                 2370             


Gly His  Asn Ser Leu Pro Thr  Gly Val Ala Pro Asn  Leu Pro Thr 
    2375                 2380                 2385             


Ile Pro  Ser Ala Ser Asp Phe  Asn Thr Val Leu Ser  Ser Asp Gln 
    2390                 2395                 2400             


Asn Thr  Leu Asp Gly Thr His  Ser Gln His Ser Thr  Ser Gln Asp 
    2405                 2410                 2415             


Asp Val  Ala Gly Val Glu Glu  Ala Asn Gln Gly Phe  Pro Ala Val 
    2420                 2425                 2430             


Gln Leu  Ala Asp Ala Gln Val  Val Phe Lys Pro Leu  Leu Ser His 
    2435                 2440                 2445             


Thr Gly  Ile Gln Ser Gln Asp  Thr Met Pro Phe Cys  Tyr Arg Met 
    2450                 2455                 2460             


Tyr Phe  Gly Glu His Leu Ser  Phe Ser Gly Thr Leu  Asp Cys Leu 
    2465                 2470                 2475             


Arg Ala  Asp Ile Val Asp Ser  Asp Thr Ala Lys Glu  Arg Lys Gly 
    2480                 2485                 2490             


Lys Arg  Ala Arg Arg Gln Gly  His Val Asn Leu Pro  Pro Leu Glu 
    2495                 2500                 2505             


Phe Lys  Pro Ala Leu Met Leu  Gly Thr Phe Ser Ile  Ser Ala Val 
    2510                 2515                 2520             


Val Met  Glu Lys Ser Val Cys  Thr Pro Gln Asn Ser  Thr Ser Ala 
    2525                 2530                 2535             


Leu Ser  Phe His Asp Leu Ser  Lys Arg Tyr Tyr Asn  Thr Phe His 
    2540                 2545                 2550             


Cys Asn  Phe Thr Ile Ser Cys  Gln Ser Ile Ser Gln  His Val Asp 
    2555                 2560                 2565             


Met Ala  Leu Val Arg Leu Ile  His Gln Phe Ser Thr  Met Ile Asp 
    2570                 2575                 2580             


Asp Ile  Lys Ala Thr Gln Thr  Asp Ile Lys Leu Ser  Arg Tyr Thr 
    2585                 2590                 2595             


Ala Gly  Ser Ala Ser Pro Thr  Pro Thr Phe Lys Thr  Arg Lys His 
    2600                 2605                 2610             


Arg Asp  Phe Arg Ser Ser Asp  Phe Ser Arg Ser Ser  Arg Gly Ser 
    2615                 2620                 2625             


Leu Asn  Gly Gly Asn Arg Val  Asn Asn Ala Lys Asn  Lys Arg Thr 
    2630                 2635                 2640             


Asn Asn  Glu Asn Asn Lys Lys  Glu Ser Arg Asn Lys  Asn Ser Leu 
    2645                 2650                 2655             


Gly Arg  Ser Glu Arg Arg Thr  Ser Lys Val Ser Arg  Lys Gly Ser 
    2660                 2665                 2670             


Lys Asp  Val Val Asp His Met  Thr Ile His Met Asp  Asp Ser Asp 
    2675                 2680                 2685             


Ser Ile  Thr Val Ser Glu Gln  Ser Glu Pro Ser Ala  Glu Cys Trp 
    2690                 2695                 2700             


Gln Asn  Met Tyr Lys Leu Leu  Asn Phe Tyr Ser Leu  Ile Ser Asp 
    2705                 2710                 2715             


Pro Thr  Gly Ile Leu Glu Lys  Ser Ser Glu Thr Phe  Gly Pro Ala 
    2720                 2725                 2730             


Gly Val  Arg Ser Pro Thr Glu  Pro Thr Cys Lys Val  Val Phe Glu 
    2735                 2740                 2745             


Asn Glu  Gln Asp Asn Ser Ser  Leu Thr Lys Thr Gln  Arg Lys Arg 
    2750                 2755                 2760             


Ser Leu  Val Thr Ser Glu Pro  Gln His Val Thr Leu  Ile Val Phe 
    2765                 2770                 2775             


Gly Ile  Gly Met Val Asn Arg  Thr His Leu Glu Ala  Asp Ile Gly 
    2780                 2785                 2790             


Gly Leu  Thr Met Glu Ser Glu  Leu Lys Arg Ile His  Gly Ser Phe 
    2795                 2800                 2805             


Thr Leu  Lys Glu Lys Met Lys  Asp Val Leu His Gln  Lys Met Thr 
    2810                 2815                 2820             


Glu Thr  Cys Ala Thr Ala His  Ile Gly Gly Val Asn  Ile Val Leu 
    2825                 2830                 2835             


Leu Glu  Gly Ile Thr Pro Asn  Ile Gln Leu Glu Asp  Phe Pro Thr 
    2840                 2845                 2850             


Ser Pro  Thr Ser Thr Ala Lys  Gln Glu Phe Leu Thr  Val Val Lys 
    2855                 2860                 2865             


Cys Ser  Ile Ala Lys Ser Gln  Ala Leu Tyr Ser Ala  Gln Arg Gly 
    2870                 2875                 2880             


Leu Lys  Thr Asn Asn Ala Ala  Val Phe Lys Val Gly  Ala Ile Ser 
    2885                 2890                 2895             


Ile Asn  Ile Pro Gln His Pro  Ala Thr Leu His Ser  Met Met Val 
    2900                 2905                 2910             


Arg Ser  Ser His Gln Leu Ser  Lys Gln Ile Ser Asp  Leu Ile Arg 
    2915                 2920                 2925             


Gln Pro  Ser Thr Ala Pro Gln  Pro Val Lys Glu Asp  Ile Ala Thr 
    2930                 2935                 2940             


Pro Leu  Pro Ser Glu Lys Thr  Pro Thr Ser Val Asn  Gln Thr Pro 
    2945                 2950                 2955             


Val Glu  Thr Asn Glu Phe Pro  Gln Leu Pro Glu Gly  Leu Glu Lys 
    2960                 2965                 2970             


Lys Pro  Ile Val Leu Lys Phe  Ser Ala Met Leu Asp  Gly Ile Ala 
    2975                 2980                 2985             


Ile Gly  Ala Ala Leu Leu Pro  Ser Leu Lys Ala Glu  Tyr Lys Met 
    2990                 2995                 3000             


Gly Arg  Met Arg Ser His Gly  Met Thr Gly Ala Gln  Thr Arg Phe 
    3005                 3010                 3015             


Thr Phe  Glu Leu Pro Asn His  Arg Leu Arg Phe Thr  Ser Lys Val 
    3020                 3025                 3030             


Ser Ala  Thr Asp Met Ser Thr  Ile Pro Pro Ser Ala  Ser Leu Asn 
    3035                 3040                 3045             


Leu Pro  Pro Val Thr Met Ser  Gly Lys Tyr Ile Met  Glu Glu His 
    3050                 3055                 3060             


Asp Ser  Tyr Ser Asp Gln Val  Trp Ser Ile Asp Glu  Leu Pro Ser 
    3065                 3070                 3075             


Lys Gln  Gly Tyr Tyr Leu Gln  Gly Asn Tyr Leu Arg  Cys Val Ala 
    3080                 3085                 3090             


Glu Val  Gly Ser Phe Glu His  Asn Leu Thr Thr Asp  Leu Leu Asn 
    3095                 3100                 3105             


His Leu  Val Phe Val Gln Lys  Val Phe Met Lys Glu  Val Asn Glu 
    3110                 3115                 3120             


Val Ile  Gln Lys Val Ser Gly  Gly Glu Gln Pro Ile  Pro Leu Trp 
    3125                 3130                 3135             


Asn Glu  His Asp Gly Thr Ala  Asp Gly Asp Lys Pro  Lys Ile Leu 
    3140                 3145                 3150             


Leu Tyr  Ser Leu Asn Leu Gln  Phe Lys Gly Ile Gln  Val Thr Ala 
    3155                 3160                 3165             


Thr Thr  Pro Ser Met Arg Ala  Val Arg Phe Glu Thr  Gly Leu Ile 
    3170                 3175                 3180             


Glu Leu  Glu Leu Ser Asn Arg  Leu Gln Thr Lys Ala  Ser Pro Gly 
    3185                 3190                 3195             


Ser Ser  Ser Tyr Leu Lys Leu  Phe Gly Lys Cys Gln  Val Asp Leu 
    3200                 3205                 3210             


Asn Leu  Ala Leu Gly Gln Ile  Val Lys His Gln Val  Tyr Glu Glu 
    3215                 3220                 3225             


Ala Gly  Ser Asp Phe His Gln  Val Ala Tyr Phe Lys  Thr Arg Ile 
    3230                 3235                 3240             


Gly Leu  Arg Asn Ala Leu Arg  Glu Glu Ile Ser Gly  Ser Ser Asp 
    3245                 3250                 3255             


Arg Glu  Ala Val Leu Ile Thr  Leu Asn Arg Pro Ile  Val Tyr Ala 
    3260                 3265                 3270             


Gln Pro  Val Ala Phe Asp Arg  Ala Val Leu Phe Trp  Leu Asn Tyr 
    3275                 3280                 3285             


Lys Ala  Ala Tyr Asp Asn Trp  Asn Glu Gln Arg Met  Ala Leu His 
    3290                 3295                 3300             


Lys Asp  Ile His Met Ala Thr  Lys Glu Val Val Asp  Met Leu Pro 
    3305                 3310                 3315             


Gly Ile  Gln Gln Thr Ser Ala  Gln Ala Phe Gly Thr  Leu Phe Leu 
    3320                 3325                 3330             


Gln Leu  Thr Val Asn Asp Leu  Gly Ile Cys Leu Pro  Ile Thr Asn 
    3335                 3340                 3345             


Thr Ala  Gln Ser Asn His Thr  Gly Asp Leu Asp Thr  Gly Ser Ala 
    3350                 3355                 3360             


Leu Val  Leu Thr Ile Glu Ser  Thr Leu Ile Thr Ala  Cys Ser Ser 
    3365                 3370                 3375             


Glu Ser  Leu Val Ser Lys Gly  His Phe Lys Asn Phe  Cys Ile Arg 
    3380                 3385                 3390             


Phe Ala  Asp Gly Phe Glu Thr  Ser Trp Asp Asp Trp  Lys Pro Glu 
    3395                 3400                 3405             


Ile His  Gly Asp Leu Val Met  Asn Ala Cys Val Val  Pro Asp Gly 
    3410                 3415                 3420             


Thr Tyr  Glu Val Cys Ser Arg  Thr Thr Gly Gln Ala  Ala Ala Glu 
    3425                 3430                 3435             


Ser Ser  Ser Ala Gly Thr Trp  Thr Leu Asn Val Leu  Trp Lys Met 
    3440                 3445                 3450             


Cys Gly  Ile Asp Val His Met  Asp Pro Asn Ile Gly  Lys Arg Leu 
    3455                 3460                 3465             


Asn Ala  Leu Gly Asn Thr Leu  Thr Thr Leu Thr Gly  Glu Glu Asp 
    3470                 3475                 3480             


Ile Asp  Asp Ile Ala Asp Leu  Asn Ser Val Asn Ile  Ala Asp Leu 
    3485                 3490                 3495             


Ser Asp  Glu Asp Glu Val Asp  Thr Met Ser Pro Thr  Ile His Thr 
    3500                 3505                 3510             


Glu Ala  Thr Asp Tyr Arg Arg  Gln Ala Ala Ser Ala  Ser Gln Pro 
    3515                 3520                 3525             


Gly Glu  Leu Arg Gly Arg Lys  Ile Met Lys Arg Ile  Val Asp Ile 
    3530                 3535                 3540             


Arg Glu  Leu Asn Glu Gln Ala  Lys Val Ile Asp Asp  Leu Lys Lys 
    3545                 3550                 3555             


Leu Gly  Ala Ser Glu Gly Thr  Ile Asn Gln Glu Ile  Gln Arg Tyr 
    3560                 3565                 3570             


Gln Gln  Leu Glu Ser Val Ala  Val Asn Asp Ile Arg  Arg Asp Val 
    3575                 3580                 3585             


Arg Lys  Lys Leu Arg Arg Ser  Ser Met Arg Ala Ala  Ser Leu Lys 
    3590                 3595                 3600             


Asp Lys  Trp Gly Leu Ser Tyr  Lys Pro Ser Tyr Ser  Arg Ser Lys 
    3605                 3610                 3615             


Ser Ile  Ser Ala Ser Gly Arg  Pro Pro Leu Lys Arg  Met Glu Arg 
    3620                 3625                 3630             


Ala Ser  Ser Arg Val Gly Glu  Thr Glu Glu Leu Pro  Glu Ile Arg 
    3635                 3640                 3645             


Val Asp  Ala Ala Ser Pro Gly  Pro Arg Val Thr Phe  Asn Ile Gln 
    3650                 3655                 3660             


Asp Thr  Phe Pro Glu Glu Thr  Glu Leu Asp Leu Leu  Ser Val Thr 
    3665                 3670                 3675             


Ile Glu  Gly Pro Ser His Tyr  Ser Ser Asn Ser Glu  Gly Ser Cys 
    3680                 3685                 3690             


Ser Val  Phe Ser Ser Pro Lys  Thr Pro Gly Gly Phe  Ser Pro Gly 
    3695                 3700                 3705             


Ile Pro  Phe Gln Thr Glu Glu  Gly Arg Arg Asp Asp  Ser Leu Ser 
    3710                 3715                 3720             


Ser Thr  Ser Glu Asp Ser Glu  Lys Asp Glu Lys Asp  Glu Asp His 
    3725                 3730                 3735             


Glu Arg  Glu Arg Phe Tyr Ile  Tyr Arg Lys Pro Ser  His Thr Ser 
    3740                 3745                 3750             


Arg Lys  Lys Ala Thr Gly Phe  Ala Ala Val His Gln  Leu Phe Thr 
    3755                 3760                 3765             


Glu Arg  Trp Pro Thr Thr Pro  Val Asn Arg Ser Leu  Ser Gly Thr 
    3770                 3775                 3780             


Ala Thr  Glu Arg Asn Ile Asp  Phe Glu Leu Asp Ile  Arg Val Glu 
    3785                 3790                 3795             


Ile Asp  Ser Gly Lys Cys Val  Leu His Pro Thr Thr  Leu Leu Gln 
    3800                 3805                 3810             


Glu His  Asp Asp Ile Ser Leu  Arg Arg Ser Tyr Asp  Arg Ser Ser 
    3815                 3820                 3825             


Arg Ser  Leu Asp Gln Asp Ser  Pro Ser Lys Lys Lys  Lys Phe Gln 
    3830                 3835                 3840             


Thr Asn  Tyr Ala Ser Thr Thr  His Leu Met Thr Gly  Lys Lys Val 
    3845                 3850                 3855             


Pro Ser  Ser Leu Gln Thr Lys  Pro Ser Asp Leu Glu  Thr Thr Val 
    3860                 3865                 3870             


Phe Tyr  Ile Pro Gly Val Asp  Val Lys Leu His Tyr  Asn Ser Lys 
    3875                 3880                 3885             


Thr Leu  Lys Thr Glu Ser Pro  Asn Ala Ser Arg Gly  Ser Ser Leu 
    3890                 3895                 3900             


Pro Arg  Thr Leu Ser Lys Glu  Ser Lys Leu Tyr Gly  Met Lys Asp 
    3905                 3910                 3915             


Ser Ala  Thr Ser Pro Pro Ser  Pro Pro Leu Pro Ser  Thr Val Gln 
    3920                 3925                 3930             


Ser Lys  Thr Asn Thr Leu Leu  Pro Pro Gln Pro Pro  Pro Ile Pro 
    3935                 3940                 3945             


Ala Ala  Lys Gly Lys Gly Ser  Gly Gly Val Lys Thr  Ala Lys Leu 
    3950                 3955                 3960             


Tyr Ala  Trp Val Ala Leu Gln  Ser Leu Pro Glu Glu  Met Val Ile 
    3965                 3970                 3975             


Ser Pro  Cys Leu Leu Asp Phe  Leu Glu Lys Ala Leu  Glu Thr Ile 
    3980                 3985                 3990             


Pro Ile  Thr Pro Val Glu Arg  Asn Tyr Thr Ala Val  Ser Ser Gln 
    3995                 4000                 4005             


Asp Glu  Asp Met Gly His Phe  Glu Ile Pro Asp Pro  Met Glu Glu 
    4010                 4015                 4020             


Ser Thr  Thr Ser Leu Val Ser  Ser Ser Thr Ser Ala  Tyr Ser Ser 
    4025                 4030                 4035             


Phe Pro  Val Asp Val Val Val  Tyr Val Arg Val Gln  Pro Ser Gln 
    4040                 4045                 4050             


Ile Lys  Phe Ser Cys Leu Pro  Val Ser Arg Val Glu  Cys Met Leu 
    4055                 4060                 4065             


Lys Leu  Pro Ser Leu Asp Leu  Val Phe Ser Ser Asn  Arg Gly Glu 
    4070                 4075                 4080             


Leu Glu  Thr Leu Gly Thr Thr  Tyr Pro Ala Glu Thr  Leu Ser Pro 
    4085                 4090                 4095             


Gly Gly  Asn Ala Thr Gln Ser  Gly Thr Lys Thr Ser  Ala Ser Lys 
    4100                 4105                 4110             


Thr Gly  Ile Pro Gly Ser Ser  Gly Leu Gly Ser Pro  Leu Gly Arg 
    4115                 4120                 4125             


Ser Arg  His Ser Ser Ser Gln  Ser Asp Leu Thr Ser  Ser Ser Ser 
    4130                 4135                 4140             


Ser Ser  Ser Gly Leu Ser Phe  Thr Ala Cys Met Ser  Asp Phe Ser 
    4145                 4150                 4155             


Leu Tyr  Val Phe His Pro Tyr  Gly Ala Gly Lys Gln  Lys Thr Ala 
    4160                 4165                 4170             


Val Ser  Gly Leu Thr Pro Gly  Ser Gly Gly Leu Gly  Asn Val Asp 
    4175                 4180                 4185             


Glu Glu  Pro Thr Ser Val Thr  Gly Arg Lys Asp Ser  Leu Ser Ile 
    4190                 4195                 4200             


Asn Leu  Glu Phe Val Lys Val  Ser Leu Ser Arg Ile  Arg Arg Ser 
    4205                 4210                 4215             


Gly Gly  Ala Ser Phe Phe Glu  Ser Gln Ser Val Ser  Lys Ser Ala 
    4220                 4225                 4230             


Ser Lys  Met Asp Thr Thr Leu  Ile Asn Ile Ser Ala  Val Cys Asp 
    4235                 4240                 4245             


Ile Gly  Ser Ala Ser Phe Lys  Tyr Asp Met Arg Arg  Leu Ser Glu 
    4250                 4255                 4260             


Ile Leu  Ala Phe Pro Arg Ala  Trp Tyr Arg Arg Ser  Ile Ala Arg 
    4265                 4270                 4275             


Arg Leu  Phe Leu Gly Asp Gln  Thr Ile Asn Leu Pro  Thr Ser Gly 
    4280                 4285                 4290             


Pro Gly  Thr Pro Asp Ser Ile  Glu Gly Val Ser Gln  His Leu Ser 
    4295                 4300                 4305             


Pro Glu  Ser Ser Arg Lys Ala  Tyr Cys Lys Thr Trp  Glu Gln Pro 
    4310                 4315                 4320             


Ser Gln  Ser Ala Ser Phe Thr  His Met Pro Gln Ser  Pro Asn Val 
    4325                 4330                 4335             


Phe Asn  Glu His Met Thr Asn  Ser Thr Met Ser Pro  Gly Thr Val 
    4340                 4345                 4350             


Gly Gln  Ser Leu Lys Ser Pro  Ala Ser Ile Arg Ser  Arg Ser Val 
    4355                 4360                 4365             


Ser Asp  Ser Ser Val Pro Arg  Arg Asp Ser Leu Ser  Lys Thr Ser 
    4370                 4375                 4380             


Thr Pro  Phe Asn Lys Ser Asn  Lys Ala Ala Ser Gln  Gln Gly Thr 
    4385                 4390                 4395             


Pro Trp  Glu Thr Leu Val Val  Phe Ala Ile Asn Leu  Lys Gln Leu 
    4400                 4405                 4410             


Asn Val  Gln Met Asn Met Ser  Asn Val Met Gly Asn  Thr Thr Trp 
    4415                 4420                 4425             


Thr Thr  Ser Gly Leu Lys Ser  Gln Gly Arg Leu Ser  Val Gly Ser 
    4430                 4435                 4440             


Asn Arg  Asp Arg Glu Ile Ser  Met Ser Val Gly Leu  Gly Arg Ser 
    4445                 4450                 4455             


Gln Leu  Asp Ser Lys Gly Gly  Val Val Gly Gly Thr  Ile Asp Val 
    4460                 4465                 4470             


Asn Ala  Leu Glu Met Val Ala  His Ile Ser Glu His  Pro Asn Gln 
    4475                 4480                 4485             


Gln Pro  Ser His Lys Ile Gln  Ile Thr Met Gly Ser  Thr Glu Ala 
    4490                 4495                 4500             


Arg Val  Asp Tyr Met Gly Ser  Ser Ile Leu Met Gly  Ile Phe Ser 
    4505                 4510                 4515             


Asn Ala  Asp Leu Lys Leu Gln  Asp Glu Trp Lys Val  Asn Leu Tyr 
    4520                 4525                 4530             


Asn Thr  Leu Asp Ser Ser Ile  Thr Asp Lys Ser Glu  Ile Phe Val 
    4535                 4540                 4545             


His Gly  Asp Leu Lys Trp Asp  Ile Phe Gln Val Met  Ile Ser Arg 
    4550                 4555                 4560             


Ser Thr  Thr Pro Asp Leu Ile  Lys Ile Gly Met Lys  Leu Gln Glu 
    4565                 4570                 4575             


Phe Phe  Thr Gln Gln Phe Asp  Thr Ser Lys Arg Ala  Leu Ser Thr 
    4580                 4585                 4590             


Trp Gly  Pro Val Pro Tyr Leu  Pro Pro Lys Thr Met  Thr Ser Asn 
    4595                 4600                 4605             


Leu Glu  Lys Ser Ser Gln Glu  Gln Leu Leu Asp Ala  Ala His His 
    4610                 4615                 4620             


Arg His  Trp Pro Gly Val Leu  Lys Val Val Ser Gly  Cys His Ile 
    4625                 4630                 4635             


Ser Leu  Phe Gln Ile Pro Leu  Pro Glu Asp Gly Met  Gln Phe Gly 
    4640                 4645                 4650             


Gly Ser  Met Ser Leu His Gly  Asn His Met Thr Leu  Ala Cys Phe 
    4655                 4660                 4665             


His Gly  Pro Asn Phe Arg Ser  Lys Ser Trp Ala Leu  Phe His Leu 
    4670                 4675                 4680             


Glu Glu  Pro Asn Ile Ala Phe  Trp Thr Glu Ala Gln  Lys Ile Trp 
    4685                 4690                 4695             


Glu Asp  Gly Ser Ser Asp His  Ser Thr Tyr Ile Val  Gln Thr Leu 
    4700                 4705                 4710             


Asp Phe  His Leu Gly His Asn  Thr Met Val Thr Lys  Pro Cys Gly 
    4715                 4720                 4725             


Ala Leu  Glu Ser Pro Met Ala  Thr Ile Thr Lys Ile  Thr Arg Arg 
    4730                 4735                 4740             


Arg His  Glu Asn Pro Pro His  Gly Val Ala Ser Val  Lys Glu Trp 
    4745                 4750                 4755             


Phe Asn  Tyr Val Thr Ala Thr  Arg Asn Glu Glu Leu  Asn Leu Leu 
    4760                 4765                 4770             


Arg Asn  Val Asp Ala Asn Asn  Thr Glu Asn Ser Thr  Thr Val Lys 
    4775                 4780                 4785             


Asn Ser  Ser Leu Leu Ser Gly  Phe Arg Gly Gly Ser  Ser Tyr Asn 
    4790                 4795                 4800             


His Glu  Thr Glu Thr Ile Phe  Ala Leu Pro Arg Met  Gln Leu Asp 
    4805                 4810                 4815             


Phe Lys  Ser Ile His Val Gln  Glu Pro Gln Glu Pro  Ser Leu Gln 
    4820                 4825                 4830             


Asp Ala  Ser Leu Lys Pro Lys  Val Glu Cys Ser Val  Val Thr Glu 
    4835                 4840                 4845             


Phe Thr  Asp His Ile Cys Val  Thr Met Asp Ala Glu  Leu Ile Met 
    4850                 4855                 4860             


Phe Leu  His Asp Leu Val Ser  Ala Tyr Leu Lys Glu  Lys Glu Lys 
    4865                 4870                 4875             


Ala Ile  Phe Pro Pro Arg Ile  Leu Ser Thr Arg Pro  Gly Gln Lys 
    4880                 4885                 4890             


Ser Pro  Ile Ile Ile His Asp  Asp Asn Ser Ser Asp  Lys Asp Arg 
    4895                 4900                 4905             


Glu Asp  Ser Ile Thr Tyr Thr  Thr Val Asp Trp Arg  Asp Phe Met 
    4910                 4915                 4920             


Cys Asn  Thr Trp His Leu Glu  Pro Thr Leu Arg Leu  Ile Ser Trp 
    4925                 4930                 4935             


Thr Gly  Arg Lys Ile Asp Pro  Val Gly Val Asp Tyr  Ile Leu Gln 
    4940                 4945                 4950             


Lys Leu  Gly Phe His His Ala  Arg Thr Thr Ile Pro  Lys Trp Leu 
    4955                 4960                 4965             


Gln Arg  Gly Val Met Asp Pro  Leu Asp Lys Val Leu  Ser Val Leu 
    4970                 4975                 4980             


Ile Lys  Lys Leu Gly Thr Ala  Leu Gln Asp Glu Lys  Glu Lys Lys 
    4985                 4990                 4995             


Gly Lys  Asp Lys Glu Glu His  
    5000                 5005 


<210>  4062
<211>  709
<212>  PRT
<213>  Homo sapiens

<400>  4062

Met Ala Thr Ala Gly Gly Gly Ser Gly Ala Asp Pro Gly Ser Arg Gly 
1               5                   10                  15      


Leu Leu Arg Leu Leu Ser Phe Cys Val Leu Leu Ala Gly Leu Cys Arg 
            20                  25                  30          


Gly Asn Ser Val Glu Arg Lys Ile Tyr Ile Pro Leu Asn Lys Thr Ala 
        35                  40                  45              


Pro Cys Val Arg Leu Leu Asn Ala Thr His Gln Ile Gly Cys Gln Ser 
    50                  55                  60                  


Ser Ile Ser Gly Asp Thr Gly Val Ile His Val Val Glu Lys Glu Glu 
65                  70                  75                  80  


Asp Leu Gln Trp Val Leu Thr Asp Gly Pro Asn Pro Pro Tyr Met Val 
                85                  90                  95      


Leu Leu Glu Ser Lys His Phe Thr Arg Asp Leu Met Glu Lys Leu Lys 
            100                 105                 110         


Gly Arg Thr Ser Arg Ile Ala Gly Leu Ala Val Ser Leu Thr Lys Pro 
        115                 120                 125             


Ser Pro Ala Ser Gly Phe Ser Pro Ser Val Gln Cys Pro Asn Asp Gly 
    130                 135                 140                 


Phe Gly Val Tyr Ser Asn Ser Tyr Gly Pro Glu Phe Ala His Cys Arg 
145                 150                 155                 160 


Glu Ile Gln Trp Asn Ser Leu Gly Asn Gly Leu Ala Tyr Glu Asp Phe 
                165                 170                 175     


Ser Phe Pro Ile Phe Leu Leu Glu Asp Glu Asn Glu Thr Lys Val Ile 
            180                 185                 190         


Lys Gln Cys Tyr Gln Asp His Asn Leu Ser Gln Asn Gly Ser Ala Pro 
        195                 200                 205             


Thr Phe Pro Leu Cys Ala Met Gln Leu Phe Ser His Met His Ala Val 
    210                 215                 220                 


Ile Ser Thr Ala Thr Cys Met Arg Arg Ser Ser Ile Gln Ser Thr Phe 
225                 230                 235                 240 


Ser Ile Asn Pro Glu Ile Val Cys Asp Pro Leu Ser Asp Tyr Asn Val 
                245                 250                 255     


Trp Ser Met Leu Lys Pro Ile Asn Thr Thr Gly Thr Leu Lys Pro Asp 
            260                 265                 270         


Asp Arg Val Val Val Ala Ala Thr Arg Leu Asp Ser Arg Ser Phe Phe 
        275                 280                 285             


Trp Asn Val Ala Pro Gly Ala Glu Ser Ala Val Ala Ser Phe Val Thr 
    290                 295                 300                 


Gln Leu Ala Ala Ala Glu Ala Leu Gln Lys Ala Pro Asp Val Thr Thr 
305                 310                 315                 320 


Leu Pro Arg Asn Val Met Phe Val Phe Phe Gln Gly Glu Thr Phe Asp 
                325                 330                 335     


Tyr Ile Gly Ser Ser Arg Met Val Tyr Asp Met Glu Lys Gly Lys Phe 
            340                 345                 350         


Pro Val Gln Leu Glu Asn Val Asp Ser Phe Val Glu Leu Gly Gln Val 
        355                 360                 365             


Ala Leu Arg Thr Ser Leu Glu Leu Trp Met His Thr Asp Pro Val Ser 
    370                 375                 380                 


Gln Lys Asn Glu Ser Val Arg Asn Gln Val Glu Asp Leu Leu Ala Thr 
385                 390                 395                 400 


Leu Glu Lys Ser Gly Ala Gly Val Pro Ala Val Ile Leu Arg Arg Pro 
                405                 410                 415     


Asn Gln Ser Gln Pro Leu Pro Pro Ser Ser Leu Gln Arg Phe Leu Arg 
            420                 425                 430         


Ala Arg Asn Ile Ser Gly Val Val Leu Ala Asp His Ser Gly Ala Phe 
        435                 440                 445             


His Asn Lys Tyr Tyr Gln Ser Ile Tyr Asp Thr Ala Glu Asn Ile Asn 
    450                 455                 460                 


Val Ser Tyr Pro Glu Trp Leu Ser Pro Glu Glu Asp Leu Asn Phe Val 
465                 470                 475                 480 


Thr Asp Thr Ala Lys Ala Leu Ala Asp Val Ala Thr Val Leu Gly Arg 
                485                 490                 495     


Ala Leu Tyr Glu Leu Ala Gly Gly Thr Asn Phe Ser Asp Thr Val Gln 
            500                 505                 510         


Ala Asp Pro Gln Thr Val Thr Arg Leu Leu Tyr Gly Phe Leu Ile Lys 
        515                 520                 525             


Ala Asn Asn Ser Trp Phe Gln Ser Ile Leu Arg Gln Asp Leu Arg Ser 
    530                 535                 540                 


Tyr Leu Gly Asp Gly Pro Leu Gln His Tyr Ile Ala Val Ser Ser Pro 
545                 550                 555                 560 


Thr Asn Thr Thr Tyr Val Val Gln Tyr Ala Leu Ala Asn Leu Thr Gly 
                565                 570                 575     


Thr Val Val Asn Leu Thr Arg Glu Gln Cys Gln Asp Pro Ser Lys Val 
            580                 585                 590         


Pro Ser Glu Asn Lys Asp Leu Tyr Glu Tyr Ser Trp Val Gln Gly Pro 
        595                 600                 605             


Leu His Ser Asn Glu Thr Asp Arg Leu Pro Arg Cys Val Arg Ser Thr 
    610                 615                 620                 


Ala Arg Leu Ala Arg Ala Leu Ser Pro Ala Phe Glu Leu Ser Gln Trp 
625                 630                 635                 640 


Ser Ser Thr Glu Tyr Ser Thr Trp Thr Glu Ser Arg Trp Lys Asp Ile 
                645                 650                 655     


Arg Ala Arg Ile Phe Leu Ile Ala Ser Lys Glu Leu Glu Leu Ile Thr 
            660                 665                 670         


Leu Thr Val Gly Phe Gly Ile Leu Ile Phe Ser Leu Ile Val Thr Tyr 
        675                 680                 685             


Cys Ile Asn Ala Lys Ala Asp Val Leu Phe Ile Ala Pro Arg Glu Pro 
    690                 695                 700                 


Gly Ala Val Ser Tyr 
705                 


<210>  4063
<211>  632
<212>  PRT
<213>  Homo sapiens

<400>  4063

Met Gln Arg Glu Glu Gly Phe Asn Thr Lys Met Ala Asp Gly Pro Asp 
1               5                   10                  15      


Glu Tyr Asp Thr Glu Ala Gly Cys Val Pro Leu Leu His Pro Glu Glu 
            20                  25                  30          


Ile Lys Pro Gln Ser His Tyr Asn His Gly Tyr Gly Glu Pro Leu Gly 
        35                  40                  45              


Arg Lys Thr His Ile Asp Asp Tyr Ser Thr Trp Asp Ile Val Lys Ala 
    50                  55                  60                  


Thr Gln Tyr Gly Ile Tyr Glu Arg Cys Arg Glu Leu Val Glu Ala Gly 
65                  70                  75                  80  


Tyr Asp Val Arg Gln Pro Asp Lys Glu Asn Val Thr Leu Leu His Trp 
                85                  90                  95      


Ala Ala Ile Asn Asn Arg Ile Asp Leu Val Lys Tyr Tyr Ile Ser Lys 
            100                 105                 110         


Gly Ala Ile Val Asp Gln Leu Gly Gly Asp Leu Asn Ser Thr Pro Leu 
        115                 120                 125             


His Trp Ala Thr Arg Gln Gly His Leu Ser Met Val Val Gln Leu Met 
    130                 135                 140                 


Lys Tyr Gly Ala Asp Pro Ser Leu Ile Asp Gly Glu Gly Cys Ser Cys 
145                 150                 155                 160 


Ile His Leu Ala Ala Gln Phe Gly His Thr Ser Ile Val Ala Tyr Leu 
                165                 170                 175     


Ile Ala Lys Gly Gln Asp Val Asp Met Met Asp Gln Asn Gly Met Thr 
            180                 185                 190         


Pro Leu Met Trp Ala Ala Tyr Arg Thr His Ser Val Asp Pro Thr Arg 
        195                 200                 205             


Leu Leu Leu Thr Phe Asn Val Ser Val Asn Leu Gly Asp Lys Tyr His 
    210                 215                 220                 


Lys Asn Thr Ala Leu His Trp Ala Val Leu Ala Gly Asn Thr Thr Val 
225                 230                 235                 240 


Ile Ser Leu Leu Leu Glu Ala Gly Ala Asn Val Asp Ala Gln Asn Ile 
                245                 250                 255     


Lys Gly Glu Ser Ala Leu Asp Leu Ala Lys Gln Arg Lys Asn Val Trp 
            260                 265                 270         


Met Ile Asn His Leu Gln Glu Ala Arg Gln Ala Lys Gly Tyr Asp Asn 
        275                 280                 285             


Pro Ser Phe Leu Arg Lys Leu Lys Ala Asp Lys Glu Phe Arg Gln Lys 
    290                 295                 300                 


Val Met Leu Gly Thr Pro Phe Leu Val Ile Trp Leu Val Gly Phe Ile 
305                 310                 315                 320 


Ala Asp Leu Asn Ile Asp Ser Trp Leu Ile Lys Gly Leu Met Tyr Gly 
                325                 330                 335     


Gly Val Trp Ala Thr Val Gln Phe Leu Ser Lys Ser Phe Phe Asp His 
            340                 345                 350         


Ser Met His Ser Ala Leu Pro Leu Gly Ile Tyr Leu Ala Thr Lys Phe 
        355                 360                 365             


Trp Met Tyr Val Thr Trp Phe Phe Trp Phe Trp Asn Asp Leu Asn Phe 
    370                 375                 380                 


Leu Phe Ile His Leu Pro Phe Leu Ala Asn Ser Val Ala Leu Phe Tyr 
385                 390                 395                 400 


Asn Phe Gly Lys Ser Trp Lys Ser Asp Pro Gly Ile Ile Lys Ala Thr 
                405                 410                 415     


Glu Glu Gln Lys Lys Lys Thr Ile Val Glu Leu Ala Glu Thr Gly Ser 
            420                 425                 430         


Leu Asp Leu Ser Ile Phe Cys Ser Thr Cys Leu Ile Arg Lys Pro Val 
        435                 440                 445             


Arg Ser Lys His Cys Gly Val Cys Asn Arg Cys Ile Ala Lys Phe Asp 
    450                 455                 460                 


His His Cys Pro Trp Val Gly Asn Cys Val Gly Ala Gly Asn His Arg 
465                 470                 475                 480 


Tyr Phe Met Gly Tyr Leu Phe Phe Leu Leu Phe Met Ile Cys Trp Met 
                485                 490                 495     


Ile Tyr Gly Cys Ile Ser Tyr Trp Gly Leu His Cys Glu Thr Thr Tyr 
            500                 505                 510         


Thr Lys Asp Gly Phe Trp Thr Tyr Ile Thr Gln Ile Ala Thr Cys Ser 
        515                 520                 525             


Pro Trp Met Phe Trp Met Phe Leu Asn Ser Val Phe His Phe Met Trp 
    530                 535                 540                 


Val Ala Val Leu Leu Met Cys Gln Met Tyr Gln Ile Ser Cys Leu Gly 
545                 550                 555                 560 


Ile Thr Thr Asn Glu Arg Met Asn Ala Arg Arg Tyr Lys His Phe Lys 
                565                 570                 575     


Val Thr Thr Thr Ser Ile Glu Ser Pro Phe Asn His Gly Cys Val Arg 
            580                 585                 590         


Asn Ile Ile Asp Phe Phe Glu Phe Arg Cys Cys Gly Leu Phe Arg Pro 
        595                 600                 605             


Val Ile Val Asp Trp Thr Arg Gln Tyr Thr Ile Glu Tyr Asp Gln Ile 
    610                 615                 620                 


Ser Gly Ser Gly Tyr Gln Leu Val 
625                 630         


<210>  4064
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  4064

Met Met Arg Thr Gln Cys Leu Leu Gly Leu Arg Thr Phe Val Ala Phe 
1               5                   10                  15      


Ala Ala Lys Leu Trp Ser Phe Phe Ile Tyr Leu Leu Arg Arg Gln Ile 
            20                  25                  30          


Arg Thr Val Ile Gln Tyr Gln Thr Val Arg Tyr Asp Ile Leu Pro Leu 
        35                  40                  45              


Ser Pro Val Ser Arg Asn Arg Leu Ala Gln Val Lys Arg Lys Ile Leu 
    50                  55                  60                  


Val Leu Asp Leu Asp Glu Thr Leu Ile His Ser His His Asp Gly Val 
65                  70                  75                  80  


Leu Arg Pro Thr Val Arg Pro Gly Thr Pro Pro Asp Phe Ile Leu Lys 
                85                  90                  95      


Val Val Ile Asp Lys His Pro Val Arg Phe Phe Val His Lys Arg Pro 
            100                 105                 110         


His Val Asp Phe Phe Leu Glu Val Val Ser Gln Trp Tyr Glu Leu Val 
        115                 120                 125             


Val Phe Thr Ala Ser Met Glu Ile Tyr Gly Ser Ala Val Ala Asp Lys 
    130                 135                 140                 


Leu Asp Asn Ser Arg Ser Ile Leu Lys Arg Arg Tyr Tyr Arg Gln His 
145                 150                 155                 160 


Cys Thr Leu Glu Leu Gly Ser Tyr Ile Lys Asp Leu Ser Val Val His 
                165                 170                 175     


Ser Asp Leu Ser Ser Ile Val Ile Leu Asp Asn Ser Pro Gly Ala Tyr 
            180                 185                 190         


Arg Ser His Pro Asp Asn Ala Ile Pro Ile Lys Ser Trp Phe Ser Asp 
        195                 200                 205             


Pro Ser Asp Thr Ala Leu Leu Asn Leu Leu Pro Met Leu Asp Ala Leu 
    210                 215                 220                 


Arg Phe Thr Ala Asp Val Arg Ser Val Leu Ser Arg Asn Leu His Gln 
225                 230                 235                 240 


His Arg Leu Trp 
                


<210>  4065
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  4065

Met Ala Gly Ile Lys Ala Leu Ile Ser Leu Ser Phe Gly Gly Ala Ile 
1               5                   10                  15      


Gly Leu Met Phe Leu Met Leu Gly Cys Ala Leu Pro Ile Tyr Asn Lys 
            20                  25                  30          


Tyr Trp Pro Leu Phe Val Leu Phe Phe Tyr Ile Leu Ser Pro Ile Pro 
        35                  40                  45              


Tyr Cys Ile Ala Arg Arg Leu Val Asp Asp Thr Asp Ala Met Ser Asn 
    50                  55                  60                  


Ala Cys Lys Glu Leu Ala Ile Phe Leu Thr Thr Gly Ile Val Val Ser 
65                  70                  75                  80  


Ala Phe Gly Leu Pro Ile Val Phe Ala Arg Ala His Leu Ile Glu Trp 
                85                  90                  95      


Gly Ala Cys Ala Leu Val Leu Thr Gly Asn Thr Val Ile Phe Ala Thr 
            100                 105                 110         


Ile Leu Gly Phe Phe Leu Val Phe Gly Ser Asn Asp Asp Phe Ser Trp 
        115                 120                 125             


Gln Gln Trp 
    130     


<210>  4066
<211>  1883
<212>  PRT
<213>  Homo sapiens

<400>  4066

Met Gly Lys Arg Ala Gly Gly Gly Ala Thr Gly Ala Thr Thr Ala Ala 
1               5                   10                  15      


Val Ser Thr Ser Ala Gly Ala Gly Leu Glu Pro Ala Ala Ala Arg Ser 
            20                  25                  30          


Gly Gly Pro Arg Ser Ala Ala Ala Gly Leu Leu Gly Ala Leu His Leu 
        35                  40                  45              


Val Met Thr Leu Val Val Ala Ala Ala Arg Ala Glu Lys Glu Ala Phe 
    50                  55                  60                  


Val Gln Ser Glu Ser Ile Ile Glu Val Leu Arg Phe Asp Asp Gly Gly 
65                  70                  75                  80  


Leu Leu Gln Thr Glu Thr Thr Leu Gly Leu Ser Ser Tyr Gln Gln Lys 
                85                  90                  95      


Ser Ile Ser Leu Tyr Arg Gly Asn Cys Arg Pro Ile Arg Phe Glu Pro 
            100                 105                 110         


Pro Met Leu Asp Phe His Glu Gln Pro Val Gly Met Pro Lys Met Glu 
        115                 120                 125             


Lys Val Tyr Leu His Asn Pro Ser Ser Glu Glu Thr Ile Thr Leu Val 
    130                 135                 140                 


Ser Ile Ser Ala Thr Thr Ser His Phe His Ala Ser Phe Phe Gln Asn 
145                 150                 155                 160 


Arg Lys Ile Leu Pro Gly Gly Asn Thr Ser Phe Asp Val Val Phe Leu 
                165                 170                 175     


Ala Arg Val Val Gly Asn Val Glu Asn Thr Leu Phe Ile Asn Thr Ser 
            180                 185                 190         


Asn His Gly Val Phe Thr Tyr Gln Val Phe Gly Val Gly Val Pro Asn 
        195                 200                 205             


Pro Tyr Arg Leu Arg Pro Phe Leu Gly Ala Arg Val Pro Val Asn Ser 
    210                 215                 220                 


Ser Phe Ser Pro Ile Ile Asn Ile His Asn Pro His Ser Glu Pro Leu 
225                 230                 235                 240 


Gln Val Val Glu Met Tyr Ser Ser Gly Gly Asp Leu His Leu Glu Leu 
                245                 250                 255     


Pro Thr Gly Gln Gln Gly Gly Thr Arg Lys Leu Trp Glu Ile Pro Pro 
            260                 265                 270         


Tyr Glu Thr Lys Gly Val Met Arg Ala Ser Phe Ser Ser Arg Glu Ala 
        275                 280                 285             


Asp Asn His Thr Ala Phe Ile Arg Ile Lys Thr Asn Ala Ser Asp Ser 
    290                 295                 300                 


Thr Glu Phe Ile Ile Leu Pro Val Glu Val Glu Val Thr Thr Ala Pro 
305                 310                 315                 320 


Gly Ile Tyr Ser Ser Thr Glu Met Leu Asp Phe Gly Thr Leu Arg Thr 
                325                 330                 335     


Gln Asp Leu Pro Lys Val Leu Asn Leu His Leu Leu Asn Ser Gly Thr 
            340                 345                 350         


Lys Asp Val Pro Ile Thr Ser Val Arg Pro Thr Pro Gln Asn Asp Ala 
        355                 360                 365             


Ile Thr Val His Phe Lys Pro Ile Thr Leu Lys Ala Ser Glu Ser Lys 
    370                 375                 380                 


Tyr Thr Lys Val Ala Ser Ile Ser Phe Asp Ala Ser Lys Ala Lys Lys 
385                 390                 395                 400 


Pro Ser Gln Phe Ser Gly Lys Ile Thr Val Lys Ala Lys Glu Lys Ser 
                405                 410                 415     


Tyr Ser Lys Leu Glu Ile Pro Tyr Gln Ala Glu Val Leu Asp Gly Tyr 
            420                 425                 430         


Leu Gly Phe Asp His Ala Ala Thr Leu Phe His Ile Arg Asp Ser Pro 
        435                 440                 445             


Ala Asp Pro Val Glu Arg Pro Ile Tyr Leu Thr Asn Thr Phe Ser Phe 
    450                 455                 460                 


Ala Ile Leu Ile His Asp Val Leu Leu Pro Glu Glu Ala Lys Thr Met 
465                 470                 475                 480 


Phe Lys Val His Asn Phe Ser Lys Pro Val Leu Ile Leu Pro Asn Glu 
                485                 490                 495     


Ser Gly Tyr Ile Phe Thr Leu Leu Phe Met Pro Ser Thr Ser Ser Met 
            500                 505                 510         


His Ile Asp Asn Asn Ile Leu Leu Ile Thr Asn Ala Ser Lys Phe His 
        515                 520                 525             


Leu Pro Val Arg Val Tyr Thr Gly Phe Leu Asp Tyr Phe Val Leu Pro 
    530                 535                 540                 


Pro Lys Ile Glu Glu Arg Phe Ile Asp Phe Gly Val Leu Ser Ala Thr 
545                 550                 555                 560 


Glu Ala Ser Asn Ile Leu Phe Ala Ile Ile Asn Ser Asn Pro Ile Glu 
                565                 570                 575     


Leu Ala Ile Lys Ser Trp His Ile Ile Gly Asp Gly Leu Ser Ile Glu 
            580                 585                 590         


Leu Val Ala Val Glu Arg Gly Asn Arg Thr Thr Ile Ile Ser Ser Leu 
        595                 600                 605             


Pro Glu Phe Glu Lys Ser Ser Leu Ser Asp Gln Ser Ser Val Thr Leu 
    610                 615                 620                 


Ala Ser Gly Tyr Phe Ala Val Phe Arg Val Lys Leu Thr Ala Lys Lys 
625                 630                 635                 640 


Leu Glu Gly Ile His Asp Gly Ala Ile Gln Ile Thr Thr Asp Tyr Glu 
                645                 650                 655     


Ile Leu Thr Ile Pro Val Lys Ala Val Ile Ala Val Gly Ser Leu Thr 
            660                 665                 670         


Cys Phe Pro Lys His Val Val Leu Pro Pro Ser Phe Pro Gly Lys Ile 
        675                 680                 685             


Val His Gln Ser Leu Asn Ile Met Asn Ser Phe Ser Gln Lys Val Lys 
    690                 695                 700                 


Ile Gln Gln Ile Arg Ser Leu Ser Glu Asp Val Arg Phe Tyr Tyr Lys 
705                 710                 715                 720 


Arg Leu Arg Gly Asn Lys Glu Asp Leu Glu Pro Gly Lys Lys Ser Lys 
                725                 730                 735     


Ile Ala Asn Ile Tyr Phe Asp Pro Gly Leu Gln Cys Gly Asp His Cys 
            740                 745                 750         


Tyr Val Gly Leu Pro Phe Leu Ser Lys Ser Glu Pro Lys Val Gln Pro 
        755                 760                 765             


Gly Val Ala Met Gln Glu Asp Met Trp Asp Ala Asp Trp Asp Leu His 
    770                 775                 780                 


Gln Ser Leu Phe Lys Gly Trp Thr Gly Ile Lys Glu Asn Ser Gly His 
785                 790                 795                 800 


Arg Leu Ser Ala Ile Phe Glu Val Asn Thr Asp Leu Gln Lys Asn Ile 
                805                 810                 815     


Ile Ser Lys Ile Thr Ala Glu Leu Ser Trp Pro Ser Ile Leu Ser Ser 
            820                 825                 830         


Pro Arg His Leu Lys Phe Pro Leu Thr Asn Thr Asn Cys Ser Ser Glu 
        835                 840                 845             


Glu Glu Ile Thr Leu Glu Asn Pro Ala Asp Val Pro Val Tyr Val Gln 
    850                 855                 860                 


Phe Ile Pro Leu Ala Leu Tyr Ser Asn Pro Ser Val Phe Val Asp Lys 
865                 870                 875                 880 


Leu Val Ser Arg Phe Asn Leu Ser Lys Val Ala Lys Ile Asp Leu Arg 
                885                 890                 895     


Thr Leu Glu Phe Gln Val Phe Arg Asn Ser Ala His Pro Leu Gln Ser 
            900                 905                 910         


Ser Thr Gly Phe Met Glu Gly Leu Ser Arg His Leu Ile Leu Asn Leu 
        915                 920                 925             


Ile Leu Lys Pro Gly Glu Lys Lys Ser Val Lys Val Lys Phe Thr Pro 
    930                 935                 940                 


Val His Asn Arg Thr Val Ser Ser Leu Ile Ile Val Arg Asn Asn Leu 
945                 950                 955                 960 


Thr Val Met Asp Ala Val Met Val Gln Gly Gln Gly Thr Thr Glu Asn 
                965                 970                 975     


Leu Arg Val Ala Gly Lys Leu Pro Gly Pro Gly Ser Ser Leu Arg Phe 
            980                 985                 990         


Lys Ile Thr Glu Ala Leu Leu Lys  Asp Cys Thr Asp Ser  Leu Lys Leu 
        995                 1000                 1005             


Arg Glu  Pro Asn Phe Thr Leu  Lys Arg Thr Phe Lys  Val Glu Asn 
    1010                 1015                 1020             


Thr Gly  Gln Leu Gln Ile His  Ile Glu Thr Ile Glu  Ile Ser Gly 
    1025                 1030                 1035             


Tyr Ser  Cys Glu Gly Tyr Gly  Phe Lys Val Val Asn  Cys Gln Glu 
    1040                 1045                 1050             


Phe Thr  Leu Ser Ala Asn Ala  Ser Arg Asp Ile Ile  Ile Leu Phe 
    1055                 1060                 1065             


Thr Pro  Asp Phe Thr Ala Ser  Arg Val Ile Arg Glu  Leu Lys Phe 
    1070                 1075                 1080             


Ile Thr  Thr Ser Gly Ser Glu  Phe Val Phe Ile Leu  Asn Ala Ser 
    1085                 1090                 1095             


Leu Pro  Tyr His Met Leu Ala  Thr Cys Ala Glu Ala  Leu Pro Arg 
    1100                 1105                 1110             


Pro Asn  Trp Glu Leu Ala Leu  Tyr Ile Ile Ile Ser  Gly Ile Met 
    1115                 1120                 1125             


Ser Ala  Leu Phe Leu Leu Val  Ile Gly Thr Ala Tyr  Leu Glu Ala 
    1130                 1135                 1140             


Gln Gly  Ile Trp Glu Pro Phe  Arg Arg Arg Leu Ser  Phe Glu Ala 
    1145                 1150                 1155             


Ser Asn  Pro Pro Phe Asp Val  Gly Arg Pro Phe Asp  Leu Arg Arg 
    1160                 1165                 1170             


Ile Val  Gly Ile Ser Ser Glu  Gly Asn Leu Asn Thr  Leu Ser Cys 
    1175                 1180                 1185             


Asp Pro  Gly His Ser Arg Gly  Phe Cys Gly Ala Gly  Gly Ser Ser 
    1190                 1195                 1200             


Ser Arg  Pro Ser Ala Gly Ser  His Lys Gln Cys Gly  Pro Ser Val 
    1205                 1210                 1215             


His Pro  His Ser Ser His Ser  Asn Arg Asn Ser Ala  Asp Val Glu 
    1220                 1225                 1230             


Asn Val  Arg Ala Lys Asn Ser  Ser Ser Thr Ser Ser  Arg Thr Ser 
    1235                 1240                 1245             


Ala Gln  Ala Ala Ser Ser Gln  Ser Ala Asn Lys Thr  Ser Pro Leu 
    1250                 1255                 1260             


Val Leu  Asp Ser Asn Thr Val  Thr Gln Gly His Thr  Ala Gly Arg 
    1265                 1270                 1275             


Lys Ser  Lys Gly Ala Lys Gln  Ser Gln His Gly Ser  Gln His His 
    1280                 1285                 1290             


Ala His  Ser Pro Leu Glu Gln  His Pro Gln Pro Pro  Leu Pro Pro 
    1295                 1300                 1305             


Pro Val  Pro Gln Pro Gln Glu  Pro Gln Pro Glu Arg  Leu Ser Pro 
    1310                 1315                 1320             


Ala Pro  Leu Ala His Pro Ser  His Pro Glu Arg Ala  Ser Ser Ala 
    1325                 1330                 1335             


Arg His  Ser Ser Glu Asp Ser  Asp Ile Thr Ser Leu  Ile Glu Ala 
    1340                 1345                 1350             


Met Asp  Lys Asp Phe Asp His  His Asp Ser Pro Ala  Leu Glu Val 
    1355                 1360                 1365             


Phe Thr  Glu Gln Pro Pro Ser  Pro Leu Pro Lys Ser  Lys Gly Lys 
    1370                 1375                 1380             


Gly Lys  Pro Leu Gln Arg Lys  Val Lys Pro Pro Lys  Lys Gln Glu 
    1385                 1390                 1395             


Glu Lys  Glu Lys Lys Gly Lys  Gly Lys Pro Gln Glu  Asp Glu Leu 
    1400                 1405                 1410             


Lys Asp  Ser Leu Ala Asp Asp  Asp Ser Ser Ser Thr  Thr Thr Glu 
    1415                 1420                 1425             


Thr Ser  Asn Pro Asp Thr Glu  Pro Leu Leu Lys Glu  Asp Thr Glu 
    1430                 1435                 1440             


Lys Gln  Lys Gly Lys Gln Ala  Met Pro Glu Lys His  Glu Ser Glu 
    1445                 1450                 1455             


Met Ser  Gln Val Lys Gln Lys  Ser Lys Lys Leu Leu  Asn Ile Lys 
    1460                 1465                 1470             


Lys Glu  Ile Pro Thr Asp Val  Lys Pro Ser Ser Leu  Glu Leu Pro 
    1475                 1480                 1485             


Tyr Thr  Pro Pro Leu Glu Ser  Lys Gln Arg Arg Asn  Leu Pro Ser 
    1490                 1495                 1500             


Lys Ile  Pro Leu Pro Thr Ala  Met Thr Ser Gly Ser  Lys Ser Arg 
    1505                 1510                 1515             


Asn Ala  Gln Lys Thr Lys Gly  Thr Ser Lys Leu Val  Asp Asn Arg 
    1520                 1525                 1530             


Pro Pro  Ala Leu Ala Lys Phe  Leu Pro Asn Ser Gln  Glu Leu Gly 
    1535                 1540                 1545             


Asn Thr  Ser Ser Ser Glu Gly  Glu Lys Asp Ser Pro  Pro Pro Glu 
    1550                 1555                 1560             


Trp Asp  Ser Val Pro Val His  Lys Pro Gly Ser Ser  Thr Asp Ser 
    1565                 1570                 1575             


Leu Tyr  Lys Leu Ser Leu Gln  Thr Leu Asn Ala Asp  Ile Phe Leu 
    1580                 1585                 1590             


Lys Gln  Arg Gln Thr Ser Pro  Thr Pro Ala Ser Pro  Ser Pro Pro 
    1595                 1600                 1605             


Ala Ala  Pro Cys Pro Phe Val  Ala Arg Gly Ser Tyr  Ser Ser Ile 
    1610                 1615                 1620             


Val Asn  Ser Ser Ser Ser Ser  Asp Pro Lys Ile Lys  Gln Pro Asn 
    1625                 1630                 1635             


Gly Ser  Lys His Lys Leu Thr  Lys Ala Ala Ser Leu  Pro Gly Lys 
    1640                 1645                 1650             


Asn Gly  Asn Pro Thr Phe Ala  Ala Val Thr Ala Gly  Tyr Asp Lys 
    1655                 1660                 1665             


Ser Pro  Gly Gly Asn Gly Phe  Ala Lys Val Ser Ser  Asn Lys Thr 
    1670                 1675                 1680             


Gly Phe  Ser Ser Ser Leu Gly  Ile Ser His Ala Pro  Val Asp Ser 
    1685                 1690                 1695             


Asp Gly  Ser Asp Ser Ser Gly  Leu Trp Ser Pro Val  Ser Asn Pro 
    1700                 1705                 1710             


Ser Ser  Pro Asp Phe Thr Pro  Leu Asn Ser Phe Ser  Ala Phe Gly 
    1715                 1720                 1725             


Asn Ser  Phe Asn Leu Thr Gly  Glu Val Phe Ser Lys  Leu Gly Leu 
    1730                 1735                 1740             


Ser Arg  Ser Cys Asn Gln Ala  Ser Gln Arg Ser Trp  Asn Glu Phe 
    1745                 1750                 1755             


Asn Ser  Gly Pro Ser Tyr Leu  Trp Glu Ser Pro Ala  Thr Asp Pro 
    1760                 1765                 1770             


Ser Pro  Ser Trp Pro Ala Ser  Ser Gly Ser Pro Thr  His Thr Ala 
    1775                 1780                 1785             


Thr Ser  Val Leu Gly Asn Thr  Ser Gly Leu Trp Ser  Thr Thr Pro 
    1790                 1795                 1800             


Phe Ser  Ser Ser Ile Trp Ser  Ser Asn Leu Ser Ser  Ala Leu Pro 
    1805                 1810                 1815             


Phe Thr  Thr Pro Ala Asn Thr  Leu Ala Ser Ile Gly  Leu Met Gly 
    1820                 1825                 1830             


Thr Glu  Asn Ser Pro Ala Pro  His Ala Pro Ser Thr  Ser Ser Pro 
    1835                 1840                 1845             


Ala Asp  Asp Leu Gly Gln Thr  Tyr Asn Pro Trp Arg  Ile Trp Ser 
    1850                 1855                 1860             


Pro Thr  Ile Gly Arg Arg Ser  Ser Asp Pro Trp Ser  Asn Ser His 
    1865                 1870                 1875             


Phe Pro  His Glu Asn 
    1880             


<210>  4067
<211>  803
<212>  PRT
<213>  Homo sapiens

<400>  4067

Met Ile Thr Leu Thr Glu Leu Lys Cys Leu Ala Asp Ala Gln Ser Ser 
1               5                   10                  15      


Tyr His Ile Leu Lys Pro Trp Trp Asp Val Phe Trp Tyr Tyr Ile Thr 
            20                  25                  30          


Leu Ile Met Leu Leu Val Ala Val Leu Ala Gly Ala Leu Gln Leu Thr 
        35                  40                  45              


Gln Ser Arg Val Leu Cys Cys Leu Pro Cys Lys Val Glu Phe Asp Asn 
    50                  55                  60                  


His Cys Ala Val Pro Trp Asp Ile Leu Lys Ala Ser Met Asn Thr Ser 
65                  70                  75                  80  


Ser Asn Pro Gly Thr Pro Leu Pro Leu Pro Leu Arg Ile Gln Asn Asp 
                85                  90                  95      


Leu His Arg Gln Gln Tyr Ser Tyr Ile Asp Ala Val Cys Tyr Glu Lys 
            100                 105                 110         


Gln Leu His Trp Phe Ala Lys Phe Phe Pro Tyr Leu Val Leu Leu His 
        115                 120                 125             


Thr Leu Ile Phe Ala Ala Cys Ser Asn Phe Trp Leu His Tyr Pro Ser 
    130                 135                 140                 


Thr Ser Ser Arg Leu Glu His Phe Val Ala Ile Leu His Lys Cys Phe 
145                 150                 155                 160 


Asp Ser Pro Trp Thr Thr Arg Ala Leu Ser Glu Thr Val Ala Glu Gln 
                165                 170                 175     


Ser Val Arg Pro Leu Lys Leu Ser Lys Ser Lys Ile Leu Leu Ser Ser 
            180                 185                 190         


Ser Gly Cys Ser Ala Asp Ile Asp Ser Gly Lys Gln Ser Leu Pro Tyr 
        195                 200                 205             


Pro Gln Pro Gly Leu Glu Ser Ala Gly Ile Glu Ser Pro Thr Ser Ser 
    210                 215                 220                 


Val Leu Asp Lys Lys Glu Gly Glu Gln Ala Lys Ala Ile Phe Glu Lys 
225                 230                 235                 240 


Val Lys Arg Phe Arg Met His Val Glu Gln Lys Asp Ile Ile Tyr Arg 
                245                 250                 255     


Val Tyr Leu Lys Gln Ile Ile Val Lys Val Ile Leu Phe Val Leu Ile 
            260                 265                 270         


Ile Thr Tyr Val Pro Tyr Phe Leu Thr His Ile Thr Leu Glu Ile Asp 
        275                 280                 285             


Cys Ser Val Asp Val Gln Ala Phe Thr Gly Tyr Lys Arg Tyr Gln Cys 
    290                 295                 300                 


Val Tyr Ser Leu Ala Glu Ile Phe Lys Val Leu Ala Ser Phe Tyr Val 
305                 310                 315                 320 


Ile Leu Val Ile Leu Tyr Gly Leu Thr Ser Ser Tyr Ser Leu Trp Trp 
                325                 330                 335     


Met Leu Arg Ser Ser Leu Lys Gln Tyr Ser Phe Glu Ala Leu Arg Glu 
            340                 345                 350         


Lys Ser Asn Tyr Ser Asp Ile Pro Asp Val Lys Asn Asp Phe Ala Phe 
        355                 360                 365             


Ile Leu His Leu Ala Asp Gln Tyr Asp Pro Leu Tyr Ser Lys Arg Phe 
    370                 375                 380                 


Ser Ile Phe Leu Ser Glu Val Ser Glu Asn Lys Leu Lys Gln Ile Asn 
385                 390                 395                 400 


Leu Asn Asn Glu Trp Thr Val Glu Lys Leu Lys Ser Lys Leu Val Lys 
                405                 410                 415     


Asn Ala Gln Asp Lys Ile Glu Leu His Leu Phe Met Leu Asn Gly Leu 
            420                 425                 430         


Pro Asp Asn Val Phe Glu Leu Thr Glu Met Glu Val Leu Ser Leu Glu 
        435                 440                 445             


Leu Ile Pro Glu Val Lys Leu Pro Ser Ala Val Ser Gln Leu Val Asn 
    450                 455                 460                 


Leu Lys Glu Leu Arg Val Tyr His Ser Ser Leu Val Val Asp His Pro 
465                 470                 475                 480 


Ala Leu Ala Phe Leu Glu Glu Asn Leu Lys Ile Leu Arg Leu Lys Phe 
                485                 490                 495     


Thr Glu Met Gly Lys Ile Pro Arg Trp Val Phe His Leu Lys Asn Leu 
            500                 505                 510         


Lys Glu Leu Tyr Leu Ser Gly Cys Val Leu Pro Glu Gln Leu Ser Thr 
        515                 520                 525             


Met Gln Leu Glu Gly Phe Gln Asp Leu Lys Asn Leu Arg Thr Leu Tyr 
    530                 535                 540                 


Leu Lys Ser Ser Leu Ser Arg Ile Pro Gln Val Val Thr Asp Leu Leu 
545                 550                 555                 560 


Pro Ser Leu Gln Lys Leu Ser Leu Asp Asn Glu Gly Ser Lys Leu Val 
                565                 570                 575     


Val Leu Asn Asn Leu Lys Lys Met Val Asn Leu Lys Ser Leu Glu Leu 
            580                 585                 590         


Ile Ser Cys Asp Leu Glu Arg Ile Pro His Ser Ile Phe Ser Leu Asn 
        595                 600                 605             


Asn Leu His Glu Leu Asp Leu Arg Glu Asn Asn Leu Lys Thr Val Glu 
    610                 615                 620                 


Glu Ile Ile Ser Phe Gln His Leu Gln Asn Leu Ser Cys Leu Lys Leu 
625                 630                 635                 640 


Trp His Asn Asn Ile Ala Tyr Ile Pro Ala Gln Ile Gly Ala Leu Ser 
                645                 650                 655     


Asn Leu Glu Gln Leu Ser Leu Asp His Asn Asn Ile Glu Asn Leu Pro 
            660                 665                 670         


Leu Gln Leu Phe Leu Cys Thr Lys Leu His Tyr Leu Asp Leu Ser Tyr 
        675                 680                 685             


Asn His Leu Thr Phe Ile Pro Glu Glu Ile Gln Tyr Leu Ser Asn Leu 
    690                 695                 700                 


Gln Tyr Phe Ala Val Thr Asn Asn Asn Ile Glu Met Leu Pro Asp Gly 
705                 710                 715                 720 


Leu Phe Gln Cys Lys Lys Leu Gln Cys Leu Leu Leu Gly Lys Asn Ser 
                725                 730                 735     


Leu Met Asn Leu Ser Pro His Val Gly Glu Leu Ser Asn Leu Thr His 
            740                 745                 750         


Leu Glu Leu Ile Gly Asn Tyr Leu Glu Thr Leu Pro Pro Glu Leu Glu 
        755                 760                 765             


Gly Cys Gln Ser Leu Lys Arg Asn Cys Leu Ile Val Glu Glu Asn Leu 
    770                 775                 780                 


Leu Asn Thr Leu Pro Leu Pro Val Thr Glu Arg Leu Gln Thr Cys Leu 
785                 790                 795                 800 


Asp Lys Cys 
            


<210>  4068
<211>  492
<212>  PRT
<213>  Homo sapiens

<400>  4068

Met Lys Leu Leu Leu Leu His Pro Ala Phe Gln Ser Cys Leu Leu Leu 
1               5                   10                  15      


Thr Leu Leu Gly Leu Trp Arg Thr Thr Pro Glu Ala His Ala Ser Ser 
            20                  25                  30          


Leu Gly Ala Pro Ala Ile Ser Ala Ala Ser Phe Leu Gln Asp Leu Ile 
        35                  40                  45              


His Arg Tyr Gly Glu Gly Asp Ser Leu Thr Leu Gln Gln Leu Lys Ala 
    50                  55                  60                  


Leu Leu Asn His Leu Asp Val Gly Val Gly Arg Gly Asn Val Thr Gln 
65                  70                  75                  80  


His Val Gln Gly His Arg Asn Leu Ser Thr Cys Phe Ser Ser Gly Asp 
                85                  90                  95      


Leu Phe Thr Ala His Asn Phe Ser Glu Gln Ser Arg Ile Gly Ser Ser 
            100                 105                 110         


Glu Leu Gln Glu Phe Cys Pro Thr Ile Leu Gln Gln Leu Asp Ser Arg 
        115                 120                 125             


Ala Cys Thr Ser Glu Asn Gln Glu Asn Glu Glu Asn Glu Gln Thr Glu 
    130                 135                 140                 


Glu Gly Arg Pro Ser Ala Val Glu Val Trp Gly Phe Gly Phe Leu Ser 
145                 150                 155                 160 


Val Ser Leu Ile Asn Leu Ala Ser Leu Leu Gly Val Leu Val Leu Pro 
                165                 170                 175     


Cys Thr Glu Lys Ala Phe Phe Ser Arg Val Leu Thr Tyr Phe Ile Ala 
            180                 185                 190         


Leu Ser Ile Gly Thr Leu Leu Ser Asn Ala Leu Phe Gln Leu Ile Pro 
        195                 200                 205             


Glu Ala Phe Gly Phe Asn Pro Leu Glu Asp Tyr Tyr Val Ser Lys Ser 
    210                 215                 220                 


Ala Val Val Phe Gly Gly Phe Tyr Leu Phe Phe Phe Thr Glu Lys Ile 
225                 230                 235                 240 


Leu Lys Ile Leu Leu Lys Gln Lys Asn Glu His His His Gly His Ser 
                245                 250                 255     


His Tyr Ala Ser Glu Ser Leu Pro Ser Lys Lys Asp Gln Glu Glu Gly 
            260                 265                 270         


Val Met Glu Lys Leu Gln Asn Gly Asp Leu Asp His Met Ile Pro Gln 
        275                 280                 285             


His Cys Ser Ser Glu Leu Asp Gly Lys Ala Pro Met Val Asp Glu Lys 
    290                 295                 300                 


Val Ile Val Gly Ser Leu Ser Val Gln Asp Leu Gln Ala Ser Gln Ser 
305                 310                 315                 320 


Ala Cys Tyr Trp Leu Lys Gly Val Arg Tyr Ser Asp Ile Gly Thr Leu 
                325                 330                 335     


Ala Trp Met Ile Thr Leu Ser Asp Gly Leu His Asn Phe Ile Asp Gly 
            340                 345                 350         


Leu Ala Ile Gly Ala Ser Phe Thr Val Ser Val Phe Gln Gly Ile Ser 
        355                 360                 365             


Thr Ser Val Ala Ile Leu Cys Glu Glu Phe Pro His Glu Leu Gly Asp 
    370                 375                 380                 


Phe Val Ile Leu Leu Asn Ala Gly Met Ser Ile Gln Gln Ala Leu Phe 
385                 390                 395                 400 


Phe Asn Phe Leu Ser Ala Cys Cys Cys Tyr Leu Gly Leu Ala Phe Gly 
                405                 410                 415     


Ile Leu Ala Gly Ser His Phe Ser Ala Asn Trp Ile Phe Ala Leu Ala 
            420                 425                 430         


Gly Gly Met Phe Leu Tyr Ile Ser Leu Ala Asp Met Phe Pro Glu Met 
        435                 440                 445             


Asn Glu Val Cys Gln Glu Asp Glu Arg Lys Gly Ser Ile Leu Ile Pro 
    450                 455                 460                 


Phe Ile Ile Gln Asn Leu Gly Leu Leu Thr Gly Phe Thr Ile Met Val 
465                 470                 475                 480 


Val Leu Thr Met Tyr Ser Gly Gln Ile Gln Ile Gly 
                485                 490         


<210>  4069
<211>  485
<212>  PRT
<213>  Homo sapiens

<400>  4069

Met Ala Ser Ser Ser Thr Val Pro Leu Gly Phe His Tyr Glu Thr Lys 
1               5                   10                  15      


Tyr Val Val Leu Ser Tyr Leu Gly Leu Leu Ser Gln Glu Lys Leu Gln 
            20                  25                  30          


Glu Gln His Leu Ser Ser Pro Gln Gly Val Gln Leu Asp Ile Ala Ser 
        35                  40                  45              


Gln Ser Leu Asp Gln Glu Ile Leu Leu Lys Val Lys Thr Glu Ile Glu 
    50                  55                  60                  


Glu Glu Leu Lys Ser Leu Asp Lys Glu Ile Ser Glu Ala Phe Thr Ser 
65                  70                  75                  80  


Thr Gly Phe Asp Arg His Thr Ser Pro Val Phe Ser Pro Ala Asn Pro 
                85                  90                  95      


Glu Ser Ser Met Glu Asp Cys Leu Ala His Leu Gly Glu Lys Val Ser 
            100                 105                 110         


Gln Glu Leu Lys Glu Pro Leu His Lys Ala Leu Gln Met Leu Leu Ser 
        115                 120                 125             


Gln Pro Val Thr Tyr Gln Ala Phe Arg Glu Cys Thr Leu Glu Thr Thr 
    130                 135                 140                 


Val His Ala Ser Gly Trp Asn Lys Ile Leu Val Pro Leu Val Leu Leu 
145                 150                 155                 160 


Arg Gln Met Leu Leu Glu Leu Thr Arg Arg Gly Gln Glu Pro Leu Ser 
                165                 170                 175     


Ala Leu Leu Gln Phe Gly Val Thr Tyr Leu Glu Asp Tyr Ser Ala Glu 
            180                 185                 190         


Tyr Ile Ile Gln Gln Gly Gly Trp Gly Thr Val Phe Ser Leu Glu Ser 
        195                 200                 205             


Glu Glu Glu Glu Tyr Pro Gly Ile Thr Ala Glu Asp Ser Asn Asp Ile 
    210                 215                 220                 


Tyr Ile Leu Pro Ser Asp Asn Ser Gly Gln Val Ser Pro Pro Glu Ser 
225                 230                 235                 240 


Pro Thr Val Thr Thr Ser Trp Gln Ser Glu Ser Leu Pro Val Ser Leu 
                245                 250                 255     


Ser Ala Ser Gln Ser Trp His Thr Glu Ser Leu Pro Val Ser Leu Gly 
            260                 265                 270         


Pro Glu Ser Trp Gln Gln Ile Ala Met Asp Pro Glu Glu Val Lys Ser 
        275                 280                 285             


Leu Asp Ser Asn Gly Ala Gly Glu Lys Ser Glu Asn Asn Ser Ser Asn 
    290                 295                 300                 


Ser Asp Ile Val His Val Glu Lys Glu Glu Val Pro Glu Gly Met Glu 
305                 310                 315                 320 


Glu Ala Ala Val Ala Ser Val Val Leu Pro Ala Arg Glu Leu Gln Glu 
                325                 330                 335     


Ala Leu Pro Glu Ala Pro Ala Pro Leu Leu Pro His Ile Thr Ala Thr 
            340                 345                 350         


Ser Leu Leu Gly Thr Arg Glu Pro Asp Thr Glu Val Ile Thr Val Glu 
        355                 360                 365             


Lys Ser Ser Pro Ala Thr Ser Leu Phe Val Glu Leu Asp Glu Glu Glu 
    370                 375                 380                 


Val Lys Ala Ala Thr Thr Glu Pro Thr Glu Val Glu Glu Val Val Pro 
385                 390                 395                 400 


Ala Leu Glu Pro Thr Glu Thr Leu Leu Ser Glu Lys Glu Ile Asn Ala 
                405                 410                 415     


Arg Glu Glu Ser Leu Val Glu Glu Leu Ser Pro Ala Ser Glu Lys Lys 
            420                 425                 430         


Pro Val Pro Pro Ser Glu Gly Lys Ser Arg Leu Ser Pro Ala Gly Glu 
        435                 440                 445             


Met Lys Pro Met Pro Leu Ser Glu Gly Lys Ser Ile Leu Leu Phe Gly 
    450                 455                 460                 


Gly Ala Ala Ala Val Ala Ile Leu Ala Val Ala Ile Gly Val Ala Leu 
465                 470                 475                 480 


Ala Leu Arg Lys Lys 
                485 


<210>  4070
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  4070

Met Ala Ile Ala Gln Leu Ala Thr Glu Tyr Val Phe Ser Asp Phe Leu 
1               5                   10                  15      


Leu Lys Glu Pro Thr Glu Pro Lys Phe Lys Gly Leu Arg Leu Glu Leu 
            20                  25                  30          


Ala Val Asp Lys Met Val Thr Cys Ile Ala Val Gly Leu Pro Leu Leu 
        35                  40                  45              


Leu Ile Ser Leu Ala Phe Ala Gln Glu Ile Ser Ile Gly Thr Gln Ile 
    50                  55                  60                  


Ser Cys Phe Ser Pro Ser Ser Phe Ser Trp Arg Gln Ala Ala Phe Val 
65                  70                  75                  80  


Asp Ser Tyr Cys Trp Ala Ala Val Gln Gln Lys Asn Ser Leu Gln Ser 
                85                  90                  95      


Glu Ser Gly Asn Leu Pro Leu Trp Leu His Lys Phe Phe Pro Tyr Ile 
            100                 105                 110         


Leu Leu Leu Phe Ala Ile Leu Leu Tyr Leu Pro Pro Leu Phe Trp Arg 
        115                 120                 125             


Phe Ala Ala Ala Pro His Ile Cys Ser Asp Leu Lys Phe Ile Met Glu 
    130                 135                 140                 


Glu Leu Asp Lys Val Tyr Asn Arg Ala Ile Lys Ala Ala Lys Ser Ala 
145                 150                 155                 160 


Arg Asp Leu Asp Met Arg Asp Gly Ala Cys Ser Val Pro Gly Val Thr 
                165                 170                 175     


Glu Asn Leu Gly Gln Ser Leu Trp Glu Val Ser Glu Ser His Phe Lys 
            180                 185                 190         


Tyr Pro Ile Val Glu Gln Tyr Leu Lys Thr Lys Lys Asn Ser Asn Asn 
        195                 200                 205             


Leu Ile Ile Lys Tyr Ile Ser Cys Arg Leu Leu Thr Leu Ile Ile Ile 
    210                 215                 220                 


Leu Leu Ala Cys Ile Tyr Leu Gly Tyr Tyr Phe Ser Leu Ser Ser Leu 
225                 230                 235                 240 


Ser Asp Glu Phe Val Cys Ser Ile Lys Ser Gly Ile Leu Arg Asn Asp 
                245                 250                 255     


Ser Thr Val Pro Asp Gln Phe Gln Cys Lys Leu Ile Ala Val Gly Ile 
            260                 265                 270         


Phe Gln Leu Leu Ser Val Ile Asn Leu Val Val Tyr Val Leu Leu Ala 
        275                 280                 285             


Pro Val Val Val Tyr Thr Leu Phe Val Pro Phe Arg Gln Lys Thr Asp 
    290                 295                 300                 


Val Leu Lys Val Tyr Glu Ile Leu Pro Thr Phe Asp Val Leu His Phe 
305                 310                 315                 320 


Lys Ser Glu Gly Tyr Asn Asp Leu Ser Leu Tyr Asn Leu Phe Leu Glu 
                325                 330                 335     


Glu Asn Ile Ser Glu Val Lys Ser Tyr Lys Cys Leu Lys Val Leu Glu 
            340                 345                 350         


Asn Ile Lys Ser Ser Gly Gln Gly Ile Asp Pro Met Leu Leu Leu Thr 
        355                 360                 365             


Asn Leu Gly Met Ile Lys Met Asp Val Val Asp Gly Lys Thr Pro Met 
    370                 375                 380                 


Ser Ala Glu Met Arg Glu Glu Gln Gly Asn Gln Thr Ala Glu Leu Gln 
385                 390                 395                 400 


Gly Met Asn Ile Asp Ser Glu Thr Lys Ala Asn Asn Gly Glu Lys Asn 
                405                 410                 415     


Ala Arg Gln Arg Leu Leu Asp Ser Ser Cys 
            420                 425     


<210>  4071
<211>  717
<212>  PRT
<213>  Homo sapiens

<400>  4071

Met Ser Arg Arg Ser Gln Arg Leu Thr Arg Tyr Ser Gln Gly Asp Asp 
1               5                   10                  15      


Asp Gly Ser Ser Ser Ser Gly Gly Ser Ser Val Ala Gly Ser Gln Ser 
            20                  25                  30          


Thr Leu Phe Lys Asp Ser Pro Leu Arg Thr Leu Lys Arg Lys Ser Ser 
        35                  40                  45              


Asn Met Lys Arg Leu Ser Pro Ala Pro Gln Leu Gly Pro Ser Ser Asp 
    50                  55                  60                  


Ala His Thr Ser Tyr Tyr Ser Glu Ser Leu Val His Glu Ser Trp Phe 
65                  70                  75                  80  


Pro Pro Arg Ser Ser Leu Glu Glu Leu His Gly Asp Ala Asn Trp Gly 
                85                  90                  95      


Glu Asp Leu Arg Val Arg Arg Arg Arg Gly Thr Gly Gly Ser Glu Ser 
            100                 105                 110         


Ser Arg Ala Ser Gly Leu Val Gly Arg Lys Ala Thr Glu Asp Phe Leu 
        115                 120                 125             


Gly Ser Ser Ser Gly Tyr Ser Ser Glu Asp Asp Tyr Val Gly Tyr Ser 
    130                 135                 140                 


Asp Val Asp Gln Gln Ser Ser Ser Ser Arg Leu Arg Ser Ala Val Ser 
145                 150                 155                 160 


Arg Ala Gly Ser Leu Leu Trp Met Val Ala Thr Ser Pro Gly Arg Leu 
                165                 170                 175     


Phe Arg Leu Leu Tyr Trp Trp Ala Gly Thr Thr Trp Tyr Arg Leu Thr 
            180                 185                 190         


Thr Ala Ala Ser Leu Leu Asp Val Phe Val Leu Thr Arg Arg Phe Ser 
        195                 200                 205             


Ser Leu Lys Thr Phe Leu Trp Phe Leu Leu Pro Leu Leu Leu Leu Thr 
    210                 215                 220                 


Cys Leu Thr Tyr Gly Ala Trp Tyr Phe Tyr Pro Tyr Gly Leu Gln Thr 
225                 230                 235                 240 


Phe His Pro Ala Leu Val Ser Trp Trp Ala Ala Lys Asp Ser Arg Arg 
                245                 250                 255     


Pro Asp Glu Gly Trp Glu Ala Arg Asp Ser Ser Pro His Phe Gln Ala 
            260                 265                 270         


Glu Gln Arg Val Met Ser Arg Val His Ser Leu Glu Arg Arg Leu Glu 
        275                 280                 285             


Ala Leu Ala Ala Glu Phe Ser Ser Asn Trp Gln Lys Glu Ala Met Arg 
    290                 295                 300                 


Leu Glu Arg Leu Glu Leu Arg Gln Gly Ala Pro Gly Gln Gly Gly Gly 
305                 310                 315                 320 


Gly Gly Leu Ser His Glu Asp Thr Leu Ala Leu Leu Glu Gly Leu Val 
                325                 330                 335     


Ser Arg Arg Glu Ala Ala Leu Lys Glu Asp Phe Arg Arg Glu Thr Ala 
            340                 345                 350         


Ala Arg Ile Gln Glu Glu Leu Ser Ala Leu Arg Ala Glu His Gln Gln 
        355                 360                 365             


Asp Ser Glu Asp Leu Phe Lys Lys Ile Val Arg Ala Ser Gln Glu Ser 
    370                 375                 380                 


Glu Ala Arg Ile Gln Gln Leu Lys Ser Glu Trp Gln Ser Met Thr Gln 
385                 390                 395                 400 


Glu Ser Phe Gln Glu Ser Ser Val Lys Glu Leu Arg Arg Leu Glu Asp 
                405                 410                 415     


Gln Leu Ala Gly Leu Gln Gln Glu Leu Ala Ala Leu Ala Leu Lys Gln 
            420                 425                 430         


Ser Ser Val Ala Glu Glu Val Gly Leu Leu Pro Gln Gln Ile Gln Ala 
        435                 440                 445             


Val Arg Asp Asp Val Glu Ser Gln Phe Pro Ala Trp Ile Ser Gln Phe 
    450                 455                 460                 


Leu Ala Arg Gly Gly Gly Gly Arg Val Gly Leu Leu Gln Arg Glu Glu 
465                 470                 475                 480 


Met Gln Ala Gln Leu Arg Glu Leu Glu Ser Lys Ile Leu Thr His Val 
                485                 490                 495     


Ala Glu Met Gln Gly Lys Ser Ala Arg Glu Ala Ala Ala Ser Leu Ser 
            500                 505                 510         


Leu Thr Leu Gln Lys Glu Gly Val Ile Gly Val Thr Glu Glu Gln Val 
        515                 520                 525             


His His Ile Val Lys Gln Ala Leu Gln Arg Tyr Ser Glu Asp Arg Ile 
    530                 535                 540                 


Gly Leu Ala Asp Tyr Ala Leu Glu Ser Gly Gly Ala Ser Val Ile Ser 
545                 550                 555                 560 


Thr Arg Cys Ser Glu Thr Tyr Glu Thr Lys Thr Ala Leu Leu Ser Leu 
                565                 570                 575     


Phe Gly Ile Pro Leu Trp Tyr His Ser Gln Ser Pro Arg Val Ile Leu 
            580                 585                 590         


Gln Pro Asp Val His Pro Gly Asn Cys Trp Ala Phe Gln Gly Pro Gln 
        595                 600                 605             


Gly Phe Ala Val Val Arg Leu Ser Ala Arg Ile Arg Pro Thr Ala Val 
    610                 615                 620                 


Thr Leu Glu His Val Pro Lys Ala Leu Ser Pro Asn Ser Thr Ile Ser 
625                 630                 635                 640 


Ser Ala Pro Lys Asp Phe Ala Ile Phe Gly Phe Asp Glu Asp Leu Gln 
                645                 650                 655     


Gln Glu Gly Thr Leu Leu Gly Lys Phe Thr Tyr Asp Gln Asp Gly Glu 
            660                 665                 670         


Pro Ile Gln Thr Phe His Phe Gln Ala Pro Thr Met Ala Thr Tyr Gln 
        675                 680                 685             


Val Val Glu Leu Arg Ile Leu Thr Asn Trp Gly His Pro Glu Tyr Thr 
    690                 695                 700                 


Cys Ile Tyr Arg Phe Arg Val His Gly Glu Pro Ala His 
705                 710                 715         


<210>  4072
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  4072

Met Asp His Lys Pro Leu Leu Gln Glu Arg Pro Pro Ala Tyr Asn Leu 
1               5                   10                  15      


Glu Ala Gly Gln Gly Asp Tyr Ala Cys Gly Pro His Gly Tyr Gly Ala 
            20                  25                  30          


Ile Pro Ala Ala Pro Pro Pro Pro Pro Tyr Pro Tyr Leu Val Thr Gly 
        35                  40                  45              


Ile Pro Thr His His Pro Arg Val Tyr Asn Ile His Ser Arg Thr Val 
    50                  55                  60                  


Thr Arg Tyr Pro Ala Asn Ser Ile Val Val Val Gly Gly Cys Pro Val 
65                  70                  75                  80  


Cys Arg Val Gly Val Leu Glu Asp Cys Phe Thr Phe Leu Gly Ile Phe 
                85                  90                  95      


Leu Ala Ile Ile Leu Phe Pro Phe Gly Phe Ile Cys Cys Phe Ala Leu 
            100                 105                 110         


Arg Lys Arg Arg Cys Pro Asn Cys Gly Ala Thr Phe Ala 
        115                 120                 125 


<210>  4073
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  4073

Met Gln Leu Leu Lys Ala Leu Trp Ala Leu Ala Gly Ala Ala Leu Cys 
1               5                   10                  15      


Cys Phe Leu Val Leu Val Ile His Ala Gln Phe Leu Lys Glu Gly Gln 
            20                  25                  30          


Leu Ala Ala Gly Thr Cys Glu Ile Val Thr Leu Asp Arg Asp Ser Ser 
        35                  40                  45              


Gln Pro Arg Arg Thr Ile Ala Arg Gln Thr Ala Arg Cys Ala Cys Arg 
    50                  55                  60                  


Lys Gly Gln Ile Ala Gly Thr Thr Arg Ala Arg Pro Ala Cys Val Asp 
65                  70                  75                  80  


Ala Arg Ile Ile Lys Thr Lys Gln Trp Cys Asp Met Leu Pro Cys Leu 
                85                  90                  95      


Glu Gly Glu Gly Cys Asp Leu Leu Ile Asn Arg Ser Gly Trp Thr Cys 
            100                 105                 110         


Thr Gln Pro Gly Gly Arg Ile Lys Thr Thr Thr Val Ser 
        115                 120                 125 


<210>  4074
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  4074

Met Ala Thr Thr Ala Ala Pro Ala Gly Gly Ala Arg Asn Gly Ala Gly 
1               5                   10                  15      


Pro Glu Trp Gly Gly Phe Glu Glu Asn Ile Gln Gly Gly Gly Ser Ala 
            20                  25                  30          


Val Ile Asp Met Glu Asn Met Asp Asp Thr Ser Gly Ser Ser Phe Glu 
        35                  40                  45              


Asp Met Gly Glu Leu His Gln Arg Leu Arg Glu Glu Glu Val Asp Ala 
    50                  55                  60                  


Asp Ala Ala Asp Ala Ala Ala Ala Glu Glu Glu Asp Gly Glu Phe Leu 
65                  70                  75                  80  


Gly Met Lys Gly Phe Lys Gly Gln Leu Ser Arg Gln Val Ala Asp Gln 
                85                  90                  95      


Met Trp Gln Ala Gly Lys Arg Gln Ala Ser Arg Ala Phe Ser Leu Tyr 
            100                 105                 110         


Ala Asn Ile Asp Ile Leu Arg Pro Tyr Phe Asp Val Glu Pro Ala Gln 
        115                 120                 125             


Val Arg Ser Arg Leu Leu Glu Ser Met Ile Pro Ile Lys Met Val Asn 
    130                 135                 140                 


Phe Pro Gln Lys Ile Ala Gly Glu Leu Tyr Gly Pro Leu Met Leu Val 
145                 150                 155                 160 


Phe Thr Leu Val Ala Ile Leu Leu His Gly Met Lys Thr Ser Asp Thr 
                165                 170                 175     


Ile Ile Arg Glu Gly Thr Leu Met Gly Thr Ala Ile Gly Thr Cys Phe 
            180                 185                 190         


Gly Tyr Trp Leu Gly Val Ser Ser Phe Ile Tyr Phe Leu Ala Tyr Leu 
        195                 200                 205             


Cys Asn Ala Gln Ile Thr Met Leu Gln Met Leu Ala Leu Leu Gly Tyr 
    210                 215                 220                 


Gly Leu Phe Gly His Cys Ile Val Leu Phe Ile Thr Tyr Asn Ile His 
225                 230                 235                 240 


Leu His Ala Leu Phe Tyr Leu Phe Trp Leu Leu Val Gly Gly Leu Ser 
                245                 250                 255     


Thr Leu Arg Met Val Ala Val Leu Val Ser Arg Thr Val Gly Pro Thr 
            260                 265                 270         


Gln Arg Leu Leu Leu Cys Gly Thr Leu Ala Ala Leu His Met Leu Phe 
        275                 280                 285             


Leu Leu Tyr Leu His Phe Ala Tyr His Lys Val Val Glu Gly Ile Leu 
    290                 295                 300                 


Asp Thr Leu Glu Gly Pro Asn Ile Pro Pro Ile Gln Arg Val Pro Arg 
305                 310                 315                 320 


Asp Ile Pro Ala Met Leu Pro Ala Ala Arg Leu Pro Thr Thr Val Leu 
                325                 330                 335     


Asn Ala Thr Ala Lys Ala Val Ala Val Thr Leu Gln Ser His 
            340                 345                 350 


<210>  4075
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  4075

Met Ala Thr Pro Leu Pro Pro Pro Ser Pro Arg His Leu Arg Leu Leu 
1               5                   10                  15      


Arg Leu Leu Leu Ser Gly Leu Val Leu Gly Ala Ala Leu Arg Gly Ala 
            20                  25                  30          


Ala Ala Gly His Pro Asp Val Ala Ala Cys Pro Gly Ser Leu Asp Cys 
        35                  40                  45              


Ala Leu Lys Arg Arg Ala Arg Cys Pro Pro Gly Ala His Ala Cys Gly 
    50                  55                  60                  


Pro Cys Leu Gln Pro Phe Gln Glu Asp Gln Gln Gly Leu Cys Val Pro 
65                  70                  75                  80  


Arg Met Arg Arg Pro Pro Gly Gly Gly Arg Pro Gln Pro Arg Leu Glu 
                85                  90                  95      


Asp Glu Ile Asp Phe Leu Ala Gln Glu Leu Ala Arg Lys Glu Ser Gly 
            100                 105                 110         


His Ser Thr Pro Pro Leu Pro Lys Asp Arg Gln Arg Leu Pro Glu Pro 
        115                 120                 125             


Ala Thr Leu Gly Phe Ser Ala Arg Gly Gln Gly Leu Glu Leu Gly Leu 
    130                 135                 140                 


Pro Ser Thr Pro Gly Thr Pro Thr Pro Thr Pro His Thr Ser Leu Gly 
145                 150                 155                 160 


Ser Pro Val Ser Ser Asp Pro Val His Met Ser Pro Leu Glu Pro Arg 
                165                 170                 175     


Gly Gly Gln Gly Asp Gly Leu Ala Leu Val Leu Ile Leu Ala Phe Cys 
            180                 185                 190         


Val Ala Gly Ala Ala Ala Leu Ser Val Ala Ser Leu Cys Trp Cys Arg 
        195                 200                 205             


Leu Gln Arg Glu Ile Arg Leu Thr Gln Lys Ala Asp Tyr Ala Thr Ala 
    210                 215                 220                 


Lys Ala Pro Gly Ser Pro Ala Ala Pro Arg Ile Ser Pro Gly Asp Gln 
225                 230                 235                 240 


Arg Leu Ala Gln Ser Ala Glu Met Tyr His Tyr Gln His Gln Arg Gln 
                245                 250                 255     


Gln Met Leu Cys Leu Glu Arg His Lys Glu Pro Pro Lys Glu Leu Asp 
            260                 265                 270         


Thr Ala Ser Ser Asp Glu Glu Asn Glu Asp Gly Asp Phe Thr Val Tyr 
        275                 280                 285             


Glu Cys Pro Gly Leu Ala Pro Thr Gly Glu Met Glu Val Arg Asn Pro 
    290                 295                 300                 


Leu Phe Asp His Ala Ala Leu Ser Ala Pro Leu Pro Ala Pro Ser Ser 
305                 310                 315                 320 


Pro Pro Ala Leu Pro 
                325 


<210>  4076
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  4076

Met Val Tyr Lys Thr Leu Phe Ala Leu Cys Ile Leu Thr Ala Gly Trp 
1               5                   10                  15      


Arg Val Gln Ser Leu Pro Thr Ser Ala Pro Leu Ser Val Ser Leu Pro 
            20                  25                  30          


Thr Asn Ile Val Pro Pro Thr Thr Ile Trp Thr Ser Ser Pro Gln Asn 
        35                  40                  45              


Thr Asp Ala Asp Thr Ala Ser Pro Ser Asn Gly Thr His Asn Asn Ser 
    50                  55                  60                  


Val Leu Pro Val Thr Ala Ser Ala Pro Thr Ser Leu Leu Pro Lys Asn 
65                  70                  75                  80  


Ile Ser Ile Glu Ser Arg Glu Glu Glu Ile Thr Ser Pro Gly Ser Asn 
                85                  90                  95      


Trp Glu Gly Thr Asn Thr Asp Pro Ser Pro Ser Gly Phe Ser Ser Thr 
            100                 105                 110         


Ser Gly Gly Val His Leu Thr Thr Thr Leu Glu Glu His Ser Ser Gly 
        115                 120                 125             


Thr Pro Glu Ala Gly Val Ala Ala Thr Leu Ser Gln Ser Ala Ala Glu 
    130                 135                 140                 


Pro Pro Thr Leu Ile Ser Pro Gln Ala Pro Ala Ser Ser Pro Ser Ser 
145                 150                 155                 160 


Leu Ser Thr Ser Pro Pro Glu Val Phe Ser Ala Ser Val Thr Thr Asn 
                165                 170                 175     


His Ser Ser Thr Val Thr Ser Thr Gln Pro Thr Gly Ala Pro Thr Ala 
            180                 185                 190         


Pro Glu Ser Pro Thr Glu Glu Ser Ser Ser Asp His Thr Pro Thr Ser 
        195                 200                 205             


His Ala Thr Ala Glu Pro Val Pro Gln Glu Lys Thr Pro Pro Thr Thr 
    210                 215                 220                 


Val Ser Gly Lys Val Met Cys Glu Leu Ile Asp Met Glu Thr Thr Thr 
225                 230                 235                 240 


Thr Phe Pro Arg Val Ile Met Gln Glu Val Glu His Ala Leu Ser Ser 
                245                 250                 255     


Gly Ser Ile Ala Ala Ile Thr Val Thr Val Ile Ala Val Val Leu Leu 
            260                 265                 270         


Val Phe Gly Val Ala Ala Tyr Leu Lys Ile Arg His Ser Ser Tyr Gly 
        275                 280                 285             


Arg Leu Leu Asp Asp His Asp Tyr Gly Ser Trp Gly Asn Tyr Asn Asn 
    290                 295                 300                 


Pro Leu Tyr Asp Asp Ser 
305                 310 


<210>  4077
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  4077

Met Val Gly Ala Leu Cys Gly Cys Trp Phe Arg Leu Gly Gly Ala Arg 
1               5                   10                  15      


Pro Leu Ile Pro Leu Gly Pro Thr Val Val Gln Thr Ser Met Ser Arg 
            20                  25                  30          


Ser Gln Val Ala Leu Leu Gly Leu Ser Leu Leu Leu Met Leu Leu Leu 
        35                  40                  45              


Tyr Val Gly Leu Pro Gly Pro Pro Glu Gln Thr Ser Cys Leu Trp Gly 
    50                  55                  60                  


Asp Pro Asn Val Thr Val Leu Ala Gly Leu Thr Pro Gly Asn Ser Pro 
65                  70                  75                  80  


Ile Phe Tyr Arg Glu Val Leu Pro Leu Asn Gln Ala His Arg Val Glu 
                85                  90                  95      


Val Val Leu Leu His Gly Lys Ala Phe Asn Ser His Thr Trp Glu Gln 
            100                 105                 110         


Leu Gly Thr Leu Gln Leu Leu Ser Gln Arg Gly Tyr Arg Ala Val Ala 
        115                 120                 125             


Leu Asp Leu Pro Gly Phe Gly Asn Ser Ala Pro Ser Lys Glu Ala Ser 
    130                 135                 140                 


Thr Glu Ala Gly Arg Ala Ala Leu Leu Glu Arg Ala Leu Arg Asp Leu 
145                 150                 155                 160 


Glu Val Gln Asn Ala Val Leu Val Ser Pro Ser Leu Ser Gly His Tyr 
                165                 170                 175     


Ala Leu Pro Phe Leu Met Arg Gly His His Gln Leu His Gly Phe Val 
            180                 185                 190         


Pro Ile Ala Pro Thr Ser Thr Gln Asn Tyr Thr Gln Glu Gln Phe Trp 
        195                 200                 205             


Ala Val Lys Thr Pro Thr Leu Ile Leu Tyr Gly Glu Leu Asp His Ile 
    210                 215                 220                 


Leu Ala Arg Glu Ser Leu Arg Gln Leu Arg His Leu Pro Asn His Ser 
225                 230                 235                 240 


Val Val Lys Leu Arg Asn Ala Gly His Ala Cys Tyr Leu His Lys Pro 
                245                 250                 255     


Gln Asp Phe His Leu Val Leu Leu Ala Phe Leu Asp His Leu Pro 
            260                 265                 270     


<210>  4078
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  4078

Met Arg Ala His Ala Gln Arg Gly Arg Gly Cys Thr Arg Arg Ser Ala 
1               5                   10                  15      


Ala Val Leu Met Ala Arg His Gly Leu Pro Leu Leu Pro Leu Leu Ser 
            20                  25                  30          


Leu Leu Val Gly Ala Trp Leu Lys Leu Gly Asn Gly Gln Ala Thr Ser 
        35                  40                  45              


Met Val Gln Leu Gln Gly Gly Arg Phe Leu Met Gly Thr Asn Ser Pro 
    50                  55                  60                  


Asp Ser Arg Asp Gly Glu Gly Pro Val Arg Glu Ala Thr Val Lys Pro 
65                  70                  75                  80  


Phe Ala Ile Asp Ile Phe Pro Val Thr Asn Lys Asp Phe Arg Asp Phe 
                85                  90                  95      


Val Arg Glu Lys Lys Tyr Arg Thr Glu Ala Glu Met Phe Gly Trp Ser 
            100                 105                 110         


Phe Val Phe Glu Asp Phe Val Ser Asp Glu Leu Arg Asn Lys Ala Thr 
        115                 120                 125             


Gln Pro Met Lys Ser Val Leu Trp Trp Leu Pro Val Glu Lys Ala Phe 
    130                 135                 140                 


Trp Arg Gln Pro Ala Gly Pro Gly Ser Gly Ile Arg Glu Arg Leu Glu 
145                 150                 155                 160 


His Pro Val Leu His Val Ser Trp Asn Asp Ala Arg Ala Tyr Cys Ala 
                165                 170                 175     


Trp Arg Gly Lys Arg Leu Pro Thr Glu Glu Glu Trp Glu Phe Ala Ala 
            180                 185                 190         


Arg Gly Gly Leu Lys Gly Gln Val Tyr Pro Trp Gly Asn Trp Phe Gln 
        195                 200                 205             


Pro Asn Arg Thr Asn Leu Trp Gln Gly Lys Phe Pro Lys Gly Asp Lys 
    210                 215                 220                 


Ala Glu Asp Gly Phe His Gly Val Ser Pro Val Asn Ala Phe Pro Ala 
225                 230                 235                 240 


Gln Asn Asn Tyr Gly Leu Tyr Asp Leu Leu Gly Asn Val Trp Glu Trp 
                245                 250                 255     


Thr Ala Ser Pro Tyr Gln Ala Ala Glu Gln Asp Met Arg Val Leu Arg 
            260                 265                 270         


Gly Ala Ser Trp Ile Asp Thr Ala Asp Gly Ser Ala Asn His Arg Ala 
        275                 280                 285             


Arg Val Thr Thr Arg Met Gly Asn Thr Pro Asp Ser Ala Ser Asp Asn 
    290                 295                 300                 


Leu Gly Phe Arg Cys Ala Ala Asp Ala Gly Arg Pro Pro Gly Glu Leu 
305                 310                 315                 320 


<210>  4079
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  4079

Met Ala Leu Ser Arg Val Cys Trp Ala Arg Ser Ala Val Trp Gly Ser 
1               5                   10                  15      


Ala Val Thr Pro Gly His Phe Val Thr Arg Arg Leu Gln Leu Gly Arg 
            20                  25                  30          


Ser Gly Leu Ala Trp Gly Ala Pro Arg Ser Ser Lys Leu His Leu Ser 
        35                  40                  45              


Pro Lys Ala Asp Val Lys Asn Leu Met Ser Tyr Val Val Thr Lys Thr 
    50                  55                  60                  


Lys Ala Ile Asn Gly Lys Tyr His Arg Phe Leu Gly Arg His Phe Pro 
65                  70                  75                  80  


Arg Phe Tyr Val Leu Tyr Thr Ile Phe Met Lys Gly Leu Gln Met Leu 
                85                  90                  95      


Trp Ala Asp Ala Lys Lys Ala Arg Arg Ile Lys Thr Asn Met Trp Lys 
            100                 105                 110         


His Asn Ile Lys Phe His Gln Leu Pro Tyr Arg Glu Met Glu His Leu 
        115                 120                 125             


Arg Gln Phe Arg Gln Asp Val Thr Lys Cys Leu Phe Leu Gly Ile Ile 
    130                 135                 140                 


Ser Ile Pro Pro Phe Ala Asn Tyr Leu Val Phe Leu Leu Met Tyr Leu 
145                 150                 155                 160 


Phe Pro Arg Gln Leu Leu Ile Arg His Phe Trp Thr Pro Lys Gln Gln 
                165                 170                 175     


Thr Asp Phe Leu Asp Ile Tyr His Ala Phe Arg Lys Gln Ser His Pro 
            180                 185                 190         


Glu Ile Ile Ser Tyr Leu Glu Lys Val Ile Pro Leu Ile Ser Asp Ala 
        195                 200                 205             


Gly Leu Arg Trp Arg Leu Thr Asp Leu Cys Thr Lys Ile Gln Arg Gly 
    210                 215                 220                 


Thr His Pro Ala Ile His Asp Ile Leu Ala Leu Arg Glu Cys Phe Ser 
225                 230                 235                 240 


Asn His Pro Leu Gly Met Asn Gln Leu Gln Ala Leu His Val Lys Ala 
                245                 250                 255     


Leu Ser Arg Ala Met Leu Leu Thr Ser Tyr Leu Pro Pro Pro Leu Leu 
            260                 265                 270         


Arg His Arg Leu Lys Thr His Thr Thr Val Ile His Gln Leu Asp Lys 
        275                 280                 285             


Ala Leu Ala Lys Leu Gly Ile Gly Gln Leu Thr Ala Gln Glu Val Lys 
    290                 295                 300                 


Ser Ala Cys Tyr Leu Arg Gly Leu Asn Ser Thr His Ile Gly Glu Asp 
305                 310                 315                 320 


Arg Cys Arg Thr Trp Leu Gly Glu Trp Leu Gln Ile Ser Cys Ser Leu 
                325                 330                 335     


Lys Glu Ala Glu Leu Ser Leu Leu Leu His Asn Val Val Leu Leu Ser 
            340                 345                 350         


Thr Asn Tyr Leu Gly Thr Arg Arg 
        355                 360 


<210>  4080
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  4080

Met Ala Ala Leu Leu Arg Ala Val Arg Arg Phe Arg Gly Lys Ala Val 
1               5                   10                  15      


Trp Glu Arg Pro Leu His Gly Leu Trp Cys Cys Ser Gly Gln Glu Asp 
            20                  25                  30          


Pro Lys Arg Trp Val Gly Ser Ser Ser Pro Ile Ser Lys Glu Lys Leu 
        35                  40                  45              


Pro Asn Ala Glu Thr Glu Lys Phe Trp Met Phe Tyr Arg Phe Asp Ala 
    50                  55                  60                  


Ile Arg Thr Phe Gly Phe Leu Ser Arg Leu Lys Leu Ala Gln Thr Ala 
65                  70                  75                  80  


Leu Thr Val Val Ala Leu Pro Pro Gly Tyr Tyr Leu Tyr Ser Gln Gly 
                85                  90                  95      


Leu Leu Thr Leu Asn Thr Val Cys Leu Met Ser Gly Ile Ser Gly Phe 
            100                 105                 110         


Ala Leu Thr Met Leu Cys Trp Met Ser Tyr Phe Leu Arg Arg Leu Val 
        115                 120                 125             


Gly Ile Leu Tyr Leu Asn Glu Ser Gly Thr Met Leu Arg Val Ala His 
    130                 135                 140                 


Leu Asn Phe Trp Gly Trp Arg Gln Asp Thr Tyr Cys Pro Met Ala Asp 
145                 150                 155                 160 


Val Ile Pro Leu Thr Glu Thr Lys Asp Arg Pro Gln Glu Met Phe Val 
                165                 170                 175     


Arg Ile Gln Arg Tyr Ser Gly Lys Gln Thr Phe Tyr Val Thr Leu Arg 
            180                 185                 190         


Tyr Gly Arg Ile Leu Asp Arg Glu Arg Phe Thr Gln Val Phe Gly Val 
        195                 200                 205             


His Gln Met Leu Lys 
    210             


<210>  4081
<211>  1075
<212>  PRT
<213>  Homo sapiens

<400>  4081

Met Arg Gly Gly Lys Cys Asn Met Leu Ser Ser Leu Gly Cys Leu Leu 
1               5                   10                  15      


Leu Cys Gly Ser Ile Thr Leu Ala Leu Gly Asn Ala Gln Lys Leu Pro 
            20                  25                  30          


Lys Gly Lys Arg Pro Asn Leu Lys Val His Ile Asn Thr Thr Ser Asp 
        35                  40                  45              


Ser Ile Leu Leu Lys Phe Leu Arg Pro Ser Pro Asn Val Lys Leu Glu 
    50                  55                  60                  


Gly Leu Leu Leu Gly Tyr Gly Ser Asn Val Ser Pro Asn Gln Tyr Phe 
65                  70                  75                  80  


Pro Leu Pro Ala Glu Gly Lys Phe Thr Glu Ala Ile Val Asp Ala Glu 
                85                  90                  95      


Pro Lys Tyr Leu Ile Val Val Arg Pro Ala Pro Pro Pro Ser Gln Lys 
            100                 105                 110         


Lys Ser Cys Ser Gly Lys Thr Arg Ser Arg Lys Pro Leu Gln Leu Val 
        115                 120                 125             


Val Gly Thr Leu Thr Pro Ser Ser Val Phe Leu Ser Trp Gly Phe Leu 
    130                 135                 140                 


Ile Asn Pro His His Asp Trp Thr Leu Pro Ser His Cys Pro Asn Asp 
145                 150                 155                 160 


Arg Phe Tyr Thr Ile Arg Tyr Arg Glu Lys Asp Lys Glu Lys Lys Trp 
                165                 170                 175     


Ile Phe Gln Ile Cys Pro Ala Thr Glu Thr Ile Val Glu Asn Leu Lys 
            180                 185                 190         


Pro Asn Thr Val Tyr Glu Phe Gly Val Lys Asp Asn Val Glu Gly Gly 
        195                 200                 205             


Ile Trp Ser Lys Ile Phe Asn His Lys Thr Val Val Gly Ser Lys Lys 
    210                 215                 220                 


Val Asn Gly Lys Ile Gln Ser Thr Tyr Asp Gln Asp His Thr Val Pro 
225                 230                 235                 240 


Ala Tyr Val Pro Arg Lys Leu Ile Pro Ile Thr Ile Ile Lys Gln Val 
                245                 250                 255     


Ile Gln Asn Val Thr His Lys Asp Ser Ala Lys Ser Pro Glu Lys Ala 
            260                 265                 270         


Pro Leu Gly Gly Val Ile Leu Val His Leu Ile Ile Pro Gly Leu Asn 
        275                 280                 285             


Glu Thr Thr Val Lys Leu Pro Ala Ser Leu Met Phe Glu Ile Ser Asp 
    290                 295                 300                 


Ala Leu Lys Thr Gln Leu Ala Lys Asn Glu Thr Leu Ala Leu Pro Ala 
305                 310                 315                 320 


Glu Ser Lys Thr Pro Glu Val Glu Lys Ile Ser Ala Arg Pro Thr Thr 
                325                 330                 335     


Val Thr Pro Glu Thr Val Pro Arg Ser Thr Lys Pro Thr Thr Ser Ser 
            340                 345                 350         


Ala Leu Asp Val Ser Glu Thr Thr Leu Ala Ser Ser Glu Lys Pro Trp 
        355                 360                 365             


Ile Val Pro Thr Ala Lys Ile Ser Glu Asp Ser Lys Val Leu Gln Pro 
    370                 375                 380                 


Gln Thr Ala Thr Tyr Asp Val Phe Ser Ser Pro Thr Thr Ser Asp Glu 
385                 390                 395                 400 


Pro Glu Ile Ser Asp Ser Tyr Thr Ala Thr Ser Asp Arg Ile Leu Asp 
                405                 410                 415     


Ser Ile Pro Pro Lys Thr Ser Arg Thr Leu Glu Gln Pro Arg Ala Thr 
            420                 425                 430         


Leu Ala Pro Ser Glu Thr Pro Phe Val Pro Gln Lys Leu Glu Ile Phe 
        435                 440                 445             


Thr Ser Pro Glu Met Gln Pro Thr Thr Pro Ala Pro Gln Gln Thr Thr 
    450                 455                 460                 


Ser Ile Pro Ser Thr Pro Lys Arg Arg Pro Arg Pro Lys Pro Pro Arg 
465                 470                 475                 480 


Thr Lys Pro Glu Arg Thr Thr Ser Ala Gly Thr Ile Thr Pro Lys Ile 
                485                 490                 495     


Ser Lys Ser Pro Glu Pro Thr Trp Thr Thr Pro Ala Pro Gly Lys Thr 
            500                 505                 510         


Gln Phe Ile Ser Leu Lys Pro Lys Ile Pro Leu Ser Pro Glu Val Thr 
        515                 520                 525             


His Thr Lys Pro Ala Pro Lys Gln Thr Pro Arg Ala Pro Pro Lys Pro 
    530                 535                 540                 


Lys Thr Ser Pro Arg Pro Arg Ile Pro Gln Thr Gln Pro Val Pro Lys 
545                 550                 555                 560 


Val Pro Gln Arg Val Thr Ala Lys Pro Lys Thr Ser Pro Ser Pro Glu 
                565                 570                 575     


Val Ser Tyr Thr Thr Pro Ala Pro Lys Asp Val Leu Leu Pro His Lys 
            580                 585                 590         


Pro Tyr Pro Glu Val Ser Gln Ser Glu Pro Ala Pro Leu Glu Thr Arg 
        595                 600                 605             


Gly Ile Pro Phe Ile Pro Met Ile Ser Pro Ser Pro Ser Gln Glu Glu 
    610                 615                 620                 


Leu Gln Thr Thr Leu Glu Glu Thr Asp Gln Ser Thr Gln Glu Pro Phe 
625                 630                 635                 640 


Thr Thr Lys Ile Pro Arg Thr Thr Glu Leu Ala Lys Thr Thr Gln Ala 
                645                 650                 655     


Pro His Arg Phe Tyr Thr Thr Val Arg Pro Arg Thr Ser Asp Lys Pro 
            660                 665                 670         


His Ile Arg Pro Gly Val Lys Gln Ala Pro Arg Pro Ser Gly Ala Asp 
        675                 680                 685             


Arg Asn Val Ser Val Asp Ser Thr His Pro Thr Lys Lys Pro Gly Thr 
    690                 695                 700                 


Arg Arg Pro Pro Leu Pro Pro Arg Pro Thr His Pro Arg Arg Lys Pro 
705                 710                 715                 720 


Leu Pro Pro Asn Asn Val Thr Gly Lys Pro Gly Ser Ala Gly Ile Ile 
                725                 730                 735     


Ser Ser Gly Pro Ile Thr Thr Pro Pro Leu Arg Ser Thr Pro Arg Pro 
            740                 745                 750         


Thr Gly Thr Pro Leu Glu Arg Ile Glu Thr Asp Ile Lys Gln Pro Thr 
        755                 760                 765             


Val Pro Ala Ser Gly Glu Glu Leu Glu Asn Ile Thr Asp Phe Ser Ser 
    770                 775                 780                 


Ser Pro Thr Arg Glu Thr Asp Pro Leu Gly Lys Pro Arg Phe Lys Gly 
785                 790                 795                 800 


Pro His Val Arg Tyr Ile Gln Lys Pro Asp Asn Ser Pro Cys Ser Ile 
                805                 810                 815     


Thr Asp Ser Val Lys Arg Phe Pro Lys Glu Glu Ala Thr Glu Gly Asn 
            820                 825                 830         


Ala Thr Ser Pro Pro Gln Asn Pro Pro Thr Asn Leu Thr Val Val Thr 
        835                 840                 845             


Val Glu Gly Cys Pro Ser Phe Val Ile Leu Asp Trp Glu Lys Pro Leu 
    850                 855                 860                 


Asn Asp Thr Val Thr Glu Tyr Glu Val Ile Ser Arg Glu Asn Gly Ser 
865                 870                 875                 880 


Phe Ser Gly Lys Asn Lys Ser Ile Gln Met Thr Asn Gln Thr Phe Ser 
                885                 890                 895     


Thr Val Glu Asn Leu Lys Pro Asn Thr Ser Tyr Glu Phe Gln Val Lys 
            900                 905                 910         


Pro Lys Asn Pro Leu Gly Glu Gly Pro Val Ser Asn Thr Val Ala Phe 
        915                 920                 925             


Ser Thr Glu Ser Ala Asp Pro Arg Val Ser Glu Pro Val Ser Ala Gly 
    930                 935                 940                 


Arg Asp Ala Ile Trp Thr Glu Arg Pro Phe Asn Ser Asp Ser Tyr Ser 
945                 950                 955                 960 


Glu Cys Lys Gly Lys Gln Tyr Val Lys Arg Thr Trp Tyr Lys Lys Phe 
                965                 970                 975     


Val Gly Val Gln Leu Cys Asn Ser Leu Arg Tyr Lys Ile Tyr Leu Ser 
            980                 985                 990         


Asp Ser Leu Thr Gly Lys Phe Tyr  Asn Ile Gly Asp Gln  Arg Gly His 
        995                 1000                 1005             


Gly Glu  Asp His Cys Gln Phe  Val Asp Ser Phe Leu  Asp Gly Arg 
    1010                 1015                 1020             


Thr Gly  Gln Gln Leu Thr Ser  Asp Gln Leu Pro Ile  Lys Glu Gly 
    1025                 1030                 1035             


Tyr Phe  Arg Ala Val Arg Gln  Glu Pro Val Gln Phe  Gly Glu Ile 
    1040                 1045                 1050             


Gly Gly  His Thr Gln Ile Asn  Tyr Val Gln Trp Tyr  Glu Cys Gly 
    1055                 1060                 1065             


Thr Thr  Ile Pro Gly Lys Trp  
    1070                 1075 


<210>  4082
<211>  838
<212>  PRT
<213>  Homo sapiens

<400>  4082

Met Gln Glu Gln Glu Ile Gly Phe Ile Ser Lys Tyr Asn Glu Gly Leu 
1               5                   10                  15      


Cys Val Asn Thr Asp Pro Val Ser Ile Leu Thr Ser Ile Leu Asp Met 
            20                  25                  30          


Ser Leu His Arg Gln Met Gly Ser Asp Arg Asp Leu Gln Ser Ser Ala 
        35                  40                  45              


Ser Ser Val Ser Leu Pro Ser Val Lys Lys Ala Pro Lys Lys Arg Arg 
    50                  55                  60                  


Ile Ser Ile Gly Ser Leu Phe Arg Arg Lys Lys Asp Asn Lys Arg Lys 
65                  70                  75                  80  


Ser Arg Glu Leu Asn Gly Gly Val Asp Gly Ile Ala Ser Ile Glu Ser 
                85                  90                  95      


Ile His Ser Glu Met Cys Thr Asp Lys Asn Ser Ile Phe Ser Thr Asn 
            100                 105                 110         


Thr Ser Ser Asp Asn Gly Leu Thr Ser Ile Ser Lys Gln Ile Gly Asp 
        115                 120                 125             


Phe Ile Glu Cys Pro Leu Cys Leu Leu Arg His Ser Lys Asp Arg Phe 
    130                 135                 140                 


Pro Asp Ile Met Thr Cys His His Arg Ser Cys Val Asp Cys Leu Arg 
145                 150                 155                 160 


Gln Tyr Leu Arg Ile Glu Ile Ser Glu Ser Arg Val Asn Ile Ser Cys 
                165                 170                 175     


Pro Glu Cys Thr Glu Arg Phe Asn Pro His Asp Ile Arg Leu Ile Leu 
            180                 185                 190         


Ser Asp Asp Val Leu Met Glu Lys Tyr Glu Glu Phe Met Leu Arg Arg 
        195                 200                 205             


Trp Leu Val Ala Asp Pro Asp Cys Arg Trp Cys Pro Ala Pro Asp Cys 
    210                 215                 220                 


Gly Tyr Ala Val Ile Ala Phe Gly Cys Ala Ser Cys Pro Lys Leu Thr 
225                 230                 235                 240 


Cys Gly Arg Glu Gly Cys Gly Thr Glu Phe Cys Tyr His Cys Lys Gln 
                245                 250                 255     


Ile Trp His Pro Asn Gln Thr Cys Asp Ala Ala Arg Gln Glu Arg Ala 
            260                 265                 270         


Gln Ser Leu Arg Leu Arg Thr Ile Arg Ser Ser Ser Ile Ser Tyr Ser 
        275                 280                 285             


Gln Glu Ser Gly Ala Ala Ala Asp Asp Ile Lys Pro Cys Pro Arg Cys 
    290                 295                 300                 


Ala Ala Tyr Ile Ile Lys Met Asn Asp Gly Ser Cys Asn His Met Thr 
305                 310                 315                 320 


Cys Ala Val Cys Gly Cys Glu Phe Cys Trp Leu Cys Met Lys Glu Ile 
                325                 330                 335     


Ser Asp Leu His Tyr Leu Ser Pro Ser Gly Cys Thr Phe Trp Gly Lys 
            340                 345                 350         


Lys Pro Trp Ser Arg Lys Lys Lys Ile Leu Trp Gln Leu Gly Thr Leu 
        355                 360                 365             


Val Gly Ala Pro Val Gly Ile Ala Leu Ile Ala Gly Ile Ala Ile Pro 
    370                 375                 380                 


Ala Met Ile Ile Gly Ile Pro Val Tyr Val Gly Arg Lys Ile His Asn 
385                 390                 395                 400 


Arg Tyr Glu Gly Lys Asp Val Ser Lys His Lys Arg Asn Leu Ala Ile 
                405                 410                 415     


Ala Gly Gly Val Thr Leu Ser Val Ile Val Ser Pro Val Val Ala Ala 
            420                 425                 430         


Val Thr Val Gly Ile Gly Val Pro Ile Met Leu Ala Tyr Val Tyr Gly 
        435                 440                 445             


Val Val Pro Ile Ser Leu Cys Arg Ser Gly Gly Cys Gly Val Ser Ala 
    450                 455                 460                 


Gly Asn Gly Lys Gly Val Arg Ile Glu Phe Asp Asp Glu Asn Asp Ile 
465                 470                 475                 480 


Asn Val Gly Gly Thr Asn Thr Ala Val Asp Thr Thr Ser Val Ala Glu 
                485                 490                 495     


Ala Arg His Asn Pro Ser Ile Gly Glu Gly Ser Val Gly Gly Leu Thr 
            500                 505                 510         


Gly Ser Leu Ser Ala Ser Gly Ser His Met Asp Arg Ile Gly Ala Ile 
        515                 520                 525             


Arg Asp Asn Leu Ser Glu Thr Ala Ser Thr Met Ala Leu Ala Gly Ala 
    530                 535                 540                 


Ser Ile Thr Gly Ser Leu Ser Gly Ser Ala Met Val Asn Cys Phe Asn 
545                 550                 555                 560 


Arg Leu Glu Val Gln Ala Asp Val Gln Lys Glu Arg Tyr Ser Leu Ser 
                565                 570                 575     


Gly Glu Ser Gly Thr Val Ser Leu Gly Thr Val Ser Asp Asn Ala Ser 
            580                 585                 590         


Thr Lys Ala Met Ala Gly Ser Ile Leu Asn Ser Tyr Ile Pro Leu Asp 
        595                 600                 605             


Lys Glu Gly Asn Ser Met Glu Val Gln Val Asp Ile Glu Ser Lys Pro 
    610                 615                 620                 


Ser Lys Phe Arg His Asn Ser Gly Ser Ser Ser Val Asp Asp Gly Ser 
625                 630                 635                 640 


Ala Thr Arg Ser His Ala Gly Gly Ser Ser Ser Gly Leu Pro Glu Gly 
                645                 650                 655     


Lys Ser Ser Ala Thr Lys Trp Ser Lys Glu Ala Thr Ala Gly Lys Lys 
            660                 665                 670         


Ser Lys Ser Gly Lys Leu Arg Lys Lys Gly Asn Met Lys Ile Asn Glu 
        675                 680                 685             


Thr Arg Glu Asp Met Asp Ala Gln Leu Leu Glu Gln Gln Ser Thr Asn 
    690                 695                 700                 


Ser Ser Glu Phe Glu Ala Pro Ser Leu Ser Asp Ser Met Pro Ser Val 
705                 710                 715                 720 


Ala Asp Ser His Ser Ser His Phe Ser Glu Phe Ser Cys Ser Asp Leu 
                725                 730                 735     


Glu Ser Met Lys Thr Ser Cys Ser His Gly Ser Ser Asp Tyr His Thr 
            740                 745                 750         


Arg Phe Ala Thr Val Asn Ile Leu Pro Glu Val Glu Asn Asp Arg Leu 
        755                 760                 765             


Glu Asn Ser Pro His Gln Cys Ser Ile Ser Val Val Thr Gln Thr Ala 
    770                 775                 780                 


Ser Cys Ser Glu Val Ser Gln Leu Asn His Ile Ala Glu Glu His Gly 
785                 790                 795                 800 


Asn Asn Gly Ile Lys Pro Asn Val Asp Leu Tyr Phe Gly Asp Ala Leu 
                805                 810                 815     


Lys Glu Thr Asn Asn Asn His Ser His Gln Thr Met Glu Leu Lys Val 
            820                 825                 830         


Ala Ile Gln Thr Glu Ile 
        835             


<210>  4083
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  4083

Met Ala Lys Pro Arg Leu Leu Val Leu Tyr Phe Ala Leu Ile Val Val 
1               5                   10                  15      


Pro Ala Trp Val Ser Ser Ile Val Leu Thr Gly Thr Ser Glu Pro Pro 
            20                  25                  30          


Asp Ala Gln Thr Val Ala Pro Ala Glu Asp Glu Thr Leu Gln Asn Glu 
        35                  40                  45              


Ala Asp Asn Gln Glu Asn Val Leu Ser Gln Leu Leu Gly Asp Tyr Asp 
    50                  55                  60                  


Lys Val Lys Ala Met Ser Glu Gly Ser Asp Cys Gln Cys Lys Cys Val 
65                  70                  75                  80  


Val Arg Pro Leu Gly Arg Asp Ala Cys Gln Arg Ile Asn Ala Gly Ala 
                85                  90                  95      


Ser Arg Lys Glu Asp Phe Tyr Thr Val Glu Thr Ile Thr Ser Gly Ser 
            100                 105                 110         


Ser Cys Lys Cys Ala Cys Val Ala Pro Pro Ser Ala Leu Asn Pro Cys 
        115                 120                 125             


Glu Gly Asp Phe Arg Leu Gln Lys Leu Arg Glu Ala Asp Ser Gln Asp 
    130                 135                 140                 


Leu Lys Leu Ser Thr Ile Ile Asp Met Leu Glu Gly Ala Phe Tyr Gly 
145                 150                 155                 160 


Leu Asp Leu Leu Lys Leu His Ser Val Thr Thr Lys Leu Val Gly Arg 
                165                 170                 175     


Val Asp Lys Leu Glu Glu Glu Val Ser Lys Asn Leu Thr Lys Glu Asn 
            180                 185                 190         


Glu Gln Ile Lys Glu Asp Met Glu Glu Ile Arg Thr Glu Met Asn Lys 
        195                 200                 205             


Arg Gly Lys Glu Asn Cys Ser Glu Asn Ile Leu Asp Ser Met Pro Asp 
    210                 215                 220                 


Ile Arg Ser Ala Leu Gln Arg Asp Ala Ala Ala Ala Tyr Ala His Pro 
225                 230                 235                 240 


Glu Tyr Glu Glu Arg Phe Leu Gln Glu Glu Thr Val Ser Gln Gln Ile 
                245                 250                 255     


Asn Ser Ile Glu Leu Leu Gln Thr Arg Pro Leu Ala Leu Pro Glu Val 
            260                 265                 270         


Val Lys Ser Gln Arg Pro Leu Gln Arg Gln Val His Leu Arg Gly Arg 
        275                 280                 285             


Pro Ala Ser Gln Pro Thr Val Ile Arg Gly Ile Thr Tyr Tyr Lys Ala 
    290                 295                 300                 


Lys Val Ser Glu Glu Glu Asn Asp Ile Glu Glu Gln Gln Asp Glu Phe 
305                 310                 315                 320 


Phe Ser Gly Asp Asn Gly Val Asp Leu Leu Ile Glu Asp Gln Leu Leu 
                325                 330                 335     


Arg His Asn Gly Leu Met Thr Ser Val Thr Arg Arg Pro Ala Ala Thr 
            340                 345                 350         


Arg Gln Gly His Ser Thr Ala Val Thr Ser Asp Leu Asn Ala Arg Thr 
        355                 360                 365             


Ala Pro Trp Ser Ser Ala Leu Pro Gln Pro Ser Thr Ser Asp Pro Ser 
    370                 375                 380                 


Ile Ala Asn His Ala Ser Val Gly Pro Thr Leu Gln Thr Thr Ser Val 
385                 390                 395                 400 


Ser Pro Asp Pro Thr Arg Glu Ser Val Leu Gln Pro Ser Pro Gln Val 
                405                 410                 415     


Pro Ala Thr Thr Val Ala His Thr Ala Thr Gln Gln Pro Ala Ala Pro 
            420                 425                 430         


Ala Pro Pro Ala Val Ser Pro Arg Glu Ala Leu Met Glu Ala Met His 
        435                 440                 445             


Thr Val Pro Val Pro Pro Thr Thr Val Arg Thr Asp Ser Leu Gly Lys 
    450                 455                 460                 


Asp Ala Pro Ala Gly Trp Gly Thr Thr Pro Ala Ser Pro Thr Leu Ser 
465                 470                 475                 480 


Pro Glu Glu Glu Asp Asp Ile Arg Asn Val Ile Gly Arg Cys Lys Asp 
                485                 490                 495     


Thr Leu Ser Thr Ile Thr Gly Pro Thr Thr Gln Asn Thr Tyr Gly Arg 
            500                 505                 510         


Asn Glu Gly Ala Trp Met Lys Asp Pro Leu Ala Lys Asp Glu Arg Ile 
        515                 520                 525             


Tyr Val Thr Asn Tyr Tyr Tyr Gly Asn Thr Leu Val Glu Phe Arg Asn 
    530                 535                 540                 


Leu Glu Asn Phe Lys Gln Gly Arg Trp Ser Asn Ser Tyr Lys Leu Pro 
545                 550                 555                 560 


Tyr Ser Trp Ile Gly Thr Gly His Val Val Tyr Asn Gly Ala Phe Tyr 
                565                 570                 575     


Tyr Asn Arg Ala Phe Thr Arg Asn Ile Ile Lys Tyr Asp Leu Lys Gln 
            580                 585                 590         


Arg Tyr Val Ala Ala Trp Ala Met Leu His Asp Val Ala Tyr Glu Glu 
        595                 600                 605             


Ala Thr Pro Trp Arg Trp Gln Gly His Ser Asp Val Asp Phe Ala Val 
    610                 615                 620                 


Asp Glu Asn Gly Leu Trp Leu Ile Tyr Pro Ala Leu Asp Asp Glu Gly 
625                 630                 635                 640 


Phe Ser Gln Glu Val Ile Val Leu Ser Lys Leu Asn Ala Ala Asp Leu 
                645                 650                 655     


Ser Thr Gln Lys Glu Thr Thr Trp Arg Thr Gly Leu Arg Arg Asn Phe 
            660                 665                 670         


Tyr Gly Asn Cys Phe Val Ile Cys Gly Val Leu Tyr Ala Val Asp Ser 
        675                 680                 685             


Tyr Asn Gln Arg Asn Ala Asn Ile Ser Tyr Ala Phe Asp Thr His Thr 
    690                 695                 700                 


Asn Thr Gln Ile Val Pro Arg Leu Leu Phe Glu Asn Glu Tyr Ser Tyr 
705                 710                 715                 720 


Thr Thr Gln Ile Asp Tyr Asn Pro Lys Asp Arg Leu Leu Tyr Ala Trp 
                725                 730                 735     


Asp Asn Gly His Gln Val Thr Tyr His Val Ile Phe Ala Tyr 
            740                 745                 750 


<210>  4084
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  4084

Met Leu Pro Leu Leu Ala Ala Leu Leu Ala Ala Ala Cys Pro Leu Pro 
1               5                   10                  15      


Pro Val Arg Gly Gly Ala Ala Asp Ala Pro Gly Leu Leu Gly Val Pro 
            20                  25                  30          


Ser Asn Ala Ser Val Asn Ala Ser Ser Ala Asp Glu Pro Ile Ala Pro 
        35                  40                  45              


Arg Leu Leu Ala Ser Ala Ala Pro Gly Pro Pro Glu Arg Pro Gly Pro 
    50                  55                  60                  


Glu Glu Ala Ala Ala Ala Ala Ala Pro Cys Asn Ile Ser Val Gln Arg 
65                  70                  75                  80  


Gln Met Leu Ser Ser Leu Leu Val Arg Trp Gly Arg Pro Arg Gly Phe 
                85                  90                  95      


Gln Cys Asp Leu Leu Leu Phe Ser Thr Asn Ala His Gly Arg Ala Phe 
            100                 105                 110         


Phe Ala Ala Ala Phe His Arg Val Gly Pro Pro Leu Leu Ile Glu His 
        115                 120                 125             


Leu Gly Leu Ala Ala Gly Gly Ala Gln Gln Asp Leu Arg Leu Cys Val 
    130                 135                 140                 


Gly Cys Gly Trp Val Arg Gly Arg Arg Thr Gly Arg Leu Arg Pro Ala 
145                 150                 155                 160 


Ala Ala Pro Ser Ala Ala Ala Ala Thr Ala Gly Ala Pro Thr Ala Leu 
                165                 170                 175     


Pro Ala Tyr Pro Ala Ala Glu Pro Pro Gly Pro Leu Trp Leu Gln Gly 
            180                 185                 190         


Glu Pro Leu His Phe Cys Cys Leu Asp Phe Ser Leu Glu Glu Leu Gln 
        195                 200                 205             


Gly Glu Pro Gly Trp Arg Leu Asn Arg Lys Pro Ile Glu Ser Thr Leu 
    210                 215                 220                 


Val Ala Cys Phe Met Thr Leu Val Ile Val Val Trp Ser Val Ala Ala 
225                 230                 235                 240 


Leu Ile Trp Pro Val Pro Ile Ile Ala Gly Phe Leu Pro Asn Gly Met 
                245                 250                 255     


Glu Gln Arg Arg Thr Thr Ala Ser Thr Thr Ala Ala Thr Pro Ala Ala 
            260                 265                 270         


Val Pro Ala Gly Thr Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        275                 280                 285             


Ala Ala Ala Ala Val Thr Ser Gly Val Ala Thr Lys 
    290                 295                 300 


<210>  4085
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  4085

Met Ala Ser Gly Ser Asn Trp Leu Ser Gly Val Asn Val Val Leu Val 
1               5                   10                  15      


Met Ala Tyr Gly Ser Leu Asp Leu Lys Glu Glu Ile Asp Ile Arg Leu 
            20                  25                  30          


Ser Arg Val Gln Asp Ile Lys Tyr Glu Pro Gln Leu Leu Ala Asp Asp 
        35                  40                  45              


Asp Ala Arg Leu Leu Gln Leu Glu Thr Gln Gly Asn Gln Ser Cys Tyr 
    50                  55                  60                  


Asn Tyr Leu Tyr Arg Met Lys Ala Leu Asp Ala Ile Arg Thr Ser Glu 
65                  70                  75                  80  


Ile Pro Phe His Ser Glu Gly Arg His Pro Arg Ser Leu Met Gly Lys 
                85                  90                  95      


Asn Phe Arg Ser Tyr Leu Leu Asp Leu Arg Asn Thr Ser Thr Pro Phe 
            100                 105                 110         


Lys Gly Val Arg Lys Ala Leu Ile Asp Thr Leu Leu Asp Gly Tyr Glu 
        115                 120                 125             


Thr Ala Arg Tyr Gly Thr Gly Val Phe Gly Gln Asn Glu Tyr Leu Arg 
    130                 135                 140                 


Tyr Gln Glu Ala Leu Ser Glu Leu Ala Thr Ala Val Lys Ala Arg Ile 
145                 150                 155                 160 


Gly Ser Ser Gln Arg His His Gln Ser Ala Ala Lys Asp Leu Thr Gln 
                165                 170                 175     


Ser Pro Glu Val Ser Pro Thr Thr Ile Gln Val Thr Tyr Leu Pro Ser 
            180                 185                 190         


Ser Gln Lys Ser Lys Arg Ala Lys His Phe Leu Glu Leu Lys Ser Phe 
        195                 200                 205             


Lys Asp Asn Tyr Asn Thr Leu Glu Ser Thr Leu 
    210                 215                 


<210>  4086
<211>  715
<212>  PRT
<213>  Homo sapiens

<400>  4086

Met Pro Ala Glu Ser Gly Lys Arg Phe Lys Pro Ser Lys Tyr Val Pro 
1               5                   10                  15      


Val Ser Ala Ala Ala Ile Phe Leu Val Gly Ala Thr Thr Leu Phe Phe 
            20                  25                  30          


Ala Phe Thr Cys Pro Gly Leu Ser Leu Tyr Val Ser Pro Ala Val Pro 
        35                  40                  45              


Ile Tyr Asn Ala Ile Met Phe Leu Phe Val Leu Ala Asn Phe Ser Met 
    50                  55                  60                  


Ala Thr Phe Met Asp Pro Gly Ile Phe Pro Arg Ala Glu Glu Asp Glu 
65                  70                  75                  80  


Asp Lys Glu Asp Asp Phe Arg Ala Pro Leu Tyr Lys Thr Val Glu Ile 
                85                  90                  95      


Lys Gly Ile Gln Val Arg Met Lys Trp Cys Ala Thr Cys Arg Phe Tyr 
            100                 105                 110         


Arg Pro Pro Arg Cys Ser His Cys Ser Val Cys Asp Asn Cys Val Glu 
        115                 120                 125             


Glu Phe Asp His His Cys Pro Trp Val Asn Asn Cys Ile Gly Arg Arg 
    130                 135                 140                 


Asn Tyr Arg Tyr Phe Phe Leu Phe Leu Leu Ser Leu Thr Ala His Ile 
145                 150                 155                 160 


Met Gly Val Phe Gly Phe Gly Leu Leu Tyr Val Leu Tyr His Ile Glu 
                165                 170                 175     


Glu Leu Ser Gly Val Arg Thr Ala Val Thr Met Ala Val Met Cys Val 
            180                 185                 190         


Ala Gly Leu Phe Phe Ile Pro Val Ala Gly Leu Thr Gly Phe His Val 
        195                 200                 205             


Val Leu Val Ala Arg Gly Arg Thr Thr Asn Glu Gln Val Thr Gly Lys 
    210                 215                 220                 


Phe Arg Gly Gly Val Asn Pro Phe Thr Asn Gly Cys Cys Asn Asn Val 
225                 230                 235                 240 


Ser Arg Val Leu Cys Ser Ser Pro Ala Pro Arg Tyr Leu Gly Arg Pro 
                245                 250                 255     


Lys Lys Glu Lys Thr Ile Val Ile Arg Pro Pro Phe Leu Arg Pro Glu 
            260                 265                 270         


Val Ser Asp Gly Gln Ile Thr Val Lys Ile Met Asp Asn Gly Ile Gln 
        275                 280                 285             


Gly Glu Leu Arg Arg Thr Lys Ser Lys Gly Ser Leu Glu Ile Thr Glu 
    290                 295                 300                 


Ser Gln Ser Ala Asp Ala Glu Pro Pro Pro Pro Pro Lys Pro Asp Leu 
305                 310                 315                 320 


Ser Arg Tyr Thr Gly Leu Arg Thr His Leu Gly Leu Ala Thr Asn Glu 
                325                 330                 335     


Asp Ser Ser Leu Leu Ala Lys Asp Ser Pro Pro Thr Pro Thr Met Tyr 
            340                 345                 350         


Lys Tyr Arg Pro Gly Tyr Ser Ser Ser Ser Thr Ser Ala Ala Met Pro 
        355                 360                 365             


His Ser Ser Ser Ala Lys Leu Ser Arg Gly Asp Ser Leu Lys Glu Pro 
    370                 375                 380                 


Thr Ser Ile Ala Glu Ser Ser Arg His Pro Ser Tyr Arg Ser Glu Pro 
385                 390                 395                 400 


Ser Leu Glu Pro Glu Ser Phe Arg Ser Pro Thr Phe Gly Lys Ser Phe 
                405                 410                 415     


His Phe Asp Pro Leu Ser Ser Gly Ser Arg Ser Ser Ser Leu Lys Ser 
            420                 425                 430         


Ala Gln Gly Thr Gly Phe Glu Leu Gly Gln Leu Gln Ser Ile Arg Ser 
        435                 440                 445             


Glu Gly Thr Thr Ser Thr Ser Tyr Lys Ser Leu Ala Asn Gln Thr Arg 
    450                 455                 460                 


Asn Gly Ser Leu Ser Tyr Asp Ser Leu Leu Thr Pro Ser Asp Ser Pro 
465                 470                 475                 480 


Asp Phe Glu Ser Val Gln Ala Gly Pro Glu Pro Asp Pro Pro Leu Gly 
                485                 490                 495     


Tyr Thr Ser Pro Phe Leu Ser Ala Arg Leu Ala Gln Gln Arg Glu Ala 
            500                 505                 510         


Glu Arg His Pro Arg Leu Val Pro Thr Gly Pro Thr His Arg Glu Pro 
        515                 520                 525             


Ser Pro Val Arg Tyr Asp Asn Leu Ser Arg His Ile Val Ala Ser Leu 
    530                 535                 540                 


Gln Glu Arg Glu Lys Leu Leu Arg Gln Ser Pro Pro Leu Pro Gly Arg 
545                 550                 555                 560 


Glu Glu Glu Pro Gly Leu Gly Asp Ser Gly Ile Gln Ser Thr Pro Gly 
                565                 570                 575     


Ser Gly His Ala Pro Arg Thr Ser Ser Ser Ser Asp Asp Ser Lys Arg 
            580                 585                 590         


Ser Pro Leu Gly Lys Thr Pro Leu Gly Arg Pro Ala Val Pro Arg Phe 
        595                 600                 605             


Gly Lys Pro Asp Gly Leu Arg Gly Arg Gly Val Gly Ser Pro Glu Pro 
    610                 615                 620                 


Gly Pro Thr Ala Pro Tyr Leu Gly Arg Ser Met Ser Tyr Ser Ser Gln 
625                 630                 635                 640 


Lys Ala Gln Pro Gly Val Ser Glu Thr Glu Glu Val Ala Leu Gln Pro 
                645                 650                 655     


Leu Leu Thr Pro Lys Asp Glu Val Gln Leu Lys Thr Thr Tyr Ser Lys 
            660                 665                 670         


Ser Asn Gly Gln Pro Lys Ser Leu Gly Ser Ala Ser Pro Gly Pro Gly 
        675                 680                 685             


Gln Pro Pro Leu Ser Ser Pro Thr Arg Gly Gly Val Lys Lys Val Ser 
    690                 695                 700                 


Gly Val Gly Gly Thr Thr Tyr Glu Ile Ser Val 
705                 710                 715 


<210>  4087
<211>  541
<212>  PRT
<213>  Homo sapiens

<400>  4087

Met Leu Ser Pro Gln Arg Val Ala Ala Ala Ala Ser Arg Gly Ala Asp 
1               5                   10                  15      


Asp Ala Met Glu Ser Ser Lys Pro Gly Pro Val Gln Val Val Leu Val 
            20                  25                  30          


Gln Lys Asp Gln His Ser Phe Glu Leu Asp Glu Lys Ala Leu Ala Ser 
        35                  40                  45              


Ile Leu Leu Gln Asp His Ile Arg Asp Leu Asp Val Val Val Val Ser 
    50                  55                  60                  


Val Ala Gly Ala Phe Arg Lys Gly Lys Ser Phe Ile Leu Asp Phe Met 
65                  70                  75                  80  


Leu Arg Tyr Leu Tyr Ser Gln Lys Glu Ser Gly His Ser Asn Trp Leu 
                85                  90                  95      


Gly Asp Pro Glu Glu Pro Leu Thr Gly Phe Ser Trp Arg Gly Gly Ser 
            100                 105                 110         


Asp Pro Glu Thr Thr Gly Ile Gln Ile Trp Ser Glu Val Phe Thr Val 
        115                 120                 125             


Glu Lys Pro Gly Gly Lys Lys Val Ala Val Val Leu Met Asp Thr Gln 
    130                 135                 140                 


Gly Ala Phe Asp Ser Gln Ser Thr Val Lys Asp Cys Ala Thr Ile Phe 
145                 150                 155                 160 


Ala Leu Ser Thr Met Thr Ser Ser Val Gln Ile Tyr Asn Leu Ser Gln 
                165                 170                 175     


Asn Ile Gln Glu Asp Asp Leu Gln Gln Leu Gln Leu Phe Thr Glu Tyr 
            180                 185                 190         


Gly Arg Leu Ala Met Asp Glu Ile Phe Gln Lys Pro Phe Gln Thr Leu 
        195                 200                 205             


Met Phe Leu Val Arg Asp Trp Ser Phe Pro Tyr Glu Tyr Ser Tyr Gly 
    210                 215                 220                 


Leu Gln Gly Gly Met Ala Phe Leu Asp Lys Arg Leu Gln Val Lys Glu 
225                 230                 235                 240 


His Gln His Glu Glu Ile Gln Asn Val Arg Asn His Ile His Ser Cys 
                245                 250                 255     


Phe Ser Asp Val Thr Cys Phe Leu Leu Pro His Pro Gly Leu Gln Val 
            260                 265                 270         


Ala Thr Ser Pro Asp Phe Asp Gly Lys Leu Lys Asp Ile Ala Gly Glu 
        275                 280                 285             


Phe Lys Glu Gln Leu Gln Ala Leu Ile Pro Tyr Val Leu Asn Pro Ser 
    290                 295                 300                 


Lys Leu Met Glu Lys Glu Ile Asn Gly Ser Lys Val Thr Cys Arg Gly 
305                 310                 315                 320 


Leu Leu Glu Tyr Phe Lys Ala Tyr Ile Lys Ile Tyr Gln Gly Glu Asp 
                325                 330                 335     


Leu Pro His Pro Lys Ser Met Leu Gln Ala Thr Ala Glu Ala Asn Asn 
            340                 345                 350         


Leu Ala Ala Ala Ala Ser Ala Lys Asp Ile Tyr Tyr Asn Asn Met Glu 
        355                 360                 365             


Glu Val Cys Gly Gly Glu Lys Pro Tyr Leu Ser Pro Asp Ile Leu Glu 
    370                 375                 380                 


Glu Lys His Cys Glu Phe Lys Gln Leu Ala Leu Asp His Phe Lys Lys 
385                 390                 395                 400 


Thr Lys Lys Met Gly Gly Lys Asp Phe Ser Phe Arg Tyr Gln Gln Glu 
                405                 410                 415     


Leu Glu Glu Glu Ile Lys Glu Leu Tyr Glu Asn Phe Cys Lys His Asn 
            420                 425                 430         


Gly Ser Lys Asn Val Phe Ser Thr Phe Arg Thr Pro Ala Val Leu Phe 
        435                 440                 445             


Thr Gly Ile Val Ala Leu Tyr Ile Ala Ser Gly Leu Thr Gly Phe Ile 
    450                 455                 460                 


Gly Leu Glu Val Val Ala Gln Leu Phe Asn Cys Met Val Gly Leu Leu 
465                 470                 475                 480 


Leu Ile Ala Leu Leu Thr Trp Gly Tyr Ile Arg Tyr Ser Gly Gln Tyr 
                485                 490                 495     


Arg Glu Leu Gly Gly Ala Ile Asp Phe Gly Ala Ala Tyr Val Leu Glu 
            500                 505                 510         


Gln Ala Ser Ser His Ile Gly Asn Ser Thr Gln Ala Thr Val Arg Asp 
        515                 520                 525             


Ala Val Val Gly Arg Pro Ser Met Asp Lys Lys Ala Gln 
    530                 535                 540     


<210>  4088
<211>  549
<212>  PRT
<213>  Homo sapiens

<400>  4088

Met Ala Arg Thr Leu Arg Pro Ser Pro Leu Cys Pro Gly Gly Gly Lys 
1               5                   10                  15      


Ala Gln Leu Ser Ser Ala Ser Leu Leu Gly Ala Gly Leu Leu Leu Gln 
            20                  25                  30          


Pro Pro Thr Pro Pro Pro Leu Leu Leu Leu Leu Phe Pro Leu Leu Leu 
        35                  40                  45              


Phe Ser Arg Leu Cys Gly Ala Leu Ala Gly Pro Ile Ile Val Glu Pro 
    50                  55                  60                  


His Val Thr Ala Val Trp Gly Lys Asn Val Ser Leu Lys Cys Leu Ile 
65                  70                  75                  80  


Glu Val Asn Glu Thr Ile Thr Gln Ile Ser Trp Glu Lys Ile His Gly 
                85                  90                  95      


Lys Ser Ser Gln Thr Val Ala Val His His Pro Gln Tyr Gly Phe Ser 
            100                 105                 110         


Val Gln Gly Glu Tyr Gln Gly Arg Val Leu Phe Lys Asn Tyr Ser Leu 
        115                 120                 125             


Asn Asp Ala Thr Ile Thr Leu His Asn Ile Gly Phe Ser Asp Ser Gly 
    130                 135                 140                 


Lys Tyr Ile Cys Lys Ala Val Thr Phe Pro Leu Gly Asn Ala Gln Ser 
145                 150                 155                 160 


Ser Thr Thr Val Thr Val Leu Val Glu Pro Thr Val Ser Leu Ile Lys 
                165                 170                 175     


Gly Pro Asp Ser Leu Ile Asp Gly Gly Asn Glu Thr Val Ala Ala Ile 
            180                 185                 190         


Cys Ile Ala Ala Thr Gly Lys Pro Val Ala His Ile Asp Trp Glu Gly 
        195                 200                 205             


Asp Leu Gly Glu Met Glu Ser Thr Thr Thr Ser Phe Pro Asn Glu Thr 
    210                 215                 220                 


Ala Thr Ile Ile Ser Gln Tyr Lys Leu Phe Pro Thr Arg Phe Ala Arg 
225                 230                 235                 240 


Gly Arg Arg Ile Thr Cys Val Val Lys His Pro Ala Leu Glu Lys Asp 
                245                 250                 255     


Ile Arg Tyr Ser Phe Ile Leu Asp Ile Gln Tyr Ala Pro Glu Val Ser 
            260                 265                 270         


Val Thr Gly Tyr Asp Gly Asn Trp Phe Val Gly Arg Lys Gly Val Asn 
        275                 280                 285             


Leu Lys Cys Asn Ala Asp Ala Asn Pro Pro Pro Phe Lys Ser Val Trp 
    290                 295                 300                 


Ser Arg Leu Asp Gly Gln Trp Pro Asp Gly Leu Leu Ala Ser Asp Asn 
305                 310                 315                 320 


Thr Leu His Phe Val His Pro Leu Thr Phe Asn Tyr Ser Gly Val Tyr 
                325                 330                 335     


Ile Cys Lys Val Thr Asn Ser Leu Gly Gln Arg Ser Asp Gln Lys Val 
            340                 345                 350         


Ile Tyr Ile Ser Asp Pro Pro Thr Thr Thr Thr Leu Gln Pro Thr Ile 
        355                 360                 365             


Gln Trp His Pro Ser Thr Ala Asp Ile Glu Asp Leu Ala Thr Glu Pro 
    370                 375                 380                 


Lys Lys Leu Pro Phe Pro Leu Ser Thr Leu Ala Thr Ile Lys Asp Asp 
385                 390                 395                 400 


Thr Ile Ala Thr Ile Ile Ala Ser Val Val Gly Gly Ala Leu Phe Ile 
                405                 410                 415     


Val Leu Val Ser Val Leu Ala Gly Ile Phe Cys Tyr Arg Arg Arg Arg 
            420                 425                 430         


Thr Phe Arg Gly Asp Tyr Phe Ala Lys Asn Tyr Ile Pro Pro Ser Asp 
        435                 440                 445             


Met Gln Lys Glu Ser Gln Ile Asp Val Leu Gln Gln Asp Glu Leu Asp 
    450                 455                 460                 


Ser Tyr Pro Asp Ser Val Lys Lys Glu Asn Lys Asn Pro Val Asn Asn 
465                 470                 475                 480 


Leu Ile Arg Lys Asp Tyr Leu Glu Glu Pro Glu Lys Thr Gln Trp Asn 
                485                 490                 495     


Asn Val Glu Asn Leu Asn Arg Phe Glu Arg Pro Met Asp Tyr Tyr Glu 
            500                 505                 510         


Asp Leu Lys Met Gly Met Lys Phe Val Ser Asp Glu His Tyr Asp Glu 
        515                 520                 525             


Asn Glu Asp Asp Leu Val Ser His Val Asp Gly Ser Val Ile Ser Arg 
    530                 535                 540                 


Arg Glu Trp Tyr Val 
545                 


<210>  4089
<211>  686
<212>  PRT
<213>  Homo sapiens

<400>  4089

Met Ala Ile Asp Arg Arg Arg Glu Ala Ala Gly Gly Gly Pro Gly Arg 
1               5                   10                  15      


Gln Pro Ala Pro Ala Glu Glu Asn Gly Ser Leu Pro Pro Gly Asp Ala 
            20                  25                  30          


Ala Ala Ser Ala Pro Leu Gly Gly Arg Ala Gly Pro Gly Gly Gly Ala 
        35                  40                  45              


Glu Ile Gln Pro Leu Pro Pro Leu His Pro Gly Gly Gly Pro His Pro 
    50                  55                  60                  


Ser Cys Cys Ser Ala Ala Ala Ala Pro Ser Leu Leu Leu Leu Asp Tyr 
65                  70                  75                  80  


Asp Gly Ser Val Leu Pro Phe Leu Gly Gly Leu Gly Gly Gly Tyr Gln 
                85                  90                  95      


Lys Thr Leu Val Leu Leu Thr Trp Ile Pro Ala Leu Phe Ile Gly Phe 
            100                 105                 110         


Ser Gln Phe Ser Asp Ser Phe Leu Leu Asp Gln Pro Asn Phe Trp Cys 
        115                 120                 125             


Arg Gly Ala Gly Lys Gly Thr Glu Leu Ala Gly Val Thr Thr Thr Gly 
    130                 135                 140                 


Arg Gly Gly Asp Met Gly Asn Trp Thr Ser Leu Pro Thr Thr Pro Phe 
145                 150                 155                 160 


Ala Thr Ala Pro Trp Glu Ala Ala Gly Asn Arg Ser Asn Ser Ser Gly 
                165                 170                 175     


Ala Asp Gly Gly Asp Thr Pro Pro Leu Pro Ser Pro Pro Asp Lys Gly 
            180                 185                 190         


Asp Asn Ala Ser Asn Cys Asp Cys Arg Ala Trp Asp Tyr Gly Ile Arg 
        195                 200                 205             


Ala Gly Leu Val Gln Asn Val Val Ser Lys Trp Asp Leu Val Cys Asp 
    210                 215                 220                 


Asn Ala Trp Lys Val His Ile Ala Lys Phe Ser Leu Leu Val Gly Leu 
225                 230                 235                 240 


Ile Phe Gly Tyr Leu Ile Thr Gly Cys Ile Ala Asp Trp Val Gly Arg 
                245                 250                 255     


Arg Pro Val Leu Leu Phe Ser Ile Ile Phe Ile Leu Ile Phe Gly Leu 
            260                 265                 270         


Thr Val Ala Leu Ser Val Asn Val Thr Met Phe Ser Thr Leu Arg Phe 
        275                 280                 285             


Phe Glu Gly Phe Cys Leu Ala Gly Ile Ile Leu Thr Leu Tyr Ala Leu 
    290                 295                 300                 


Arg Ile Glu Leu Cys Pro Pro Gly Lys Arg Phe Met Ile Thr Met Val 
305                 310                 315                 320 


Ala Ser Phe Val Ala Met Ala Gly Gln Phe Leu Met Pro Gly Leu Ala 
                325                 330                 335     


Ala Leu Cys Arg Asp Trp Gln Val Leu Gln Ala Leu Ile Ile Cys Pro 
            340                 345                 350         


Phe Leu Leu Met Leu Leu Tyr Trp Ser Ile Phe Pro Glu Ser Leu Arg 
        355                 360                 365             


Trp Leu Met Ala Thr Gln Gln Phe Glu Ser Ala Lys Arg Leu Ile Leu 
    370                 375                 380                 


His Phe Thr Gln Lys Asn Arg Met Asn Pro Glu Gly Asp Ile Lys Gly 
385                 390                 395                 400 


Val Ile Pro Glu Leu Glu Lys Glu Leu Ser Arg Arg Pro Lys Lys Val 
                405                 410                 415     


Cys Ile Val Lys Val Val Gly Thr Arg Asn Leu Trp Lys Asn Ile Val 
            420                 425                 430         


Val Leu Cys Val Asn Ser Leu Thr Gly Tyr Gly Ile His His Cys Phe 
        435                 440                 445             


Ala Arg Ser Met Met Gly His Glu Val Lys Val Pro Leu Leu Glu Asn 
    450                 455                 460                 


Phe Tyr Ala Asp Tyr Tyr Thr Thr Ala Ser Ile Ala Leu Val Ser Cys 
465                 470                 475                 480 


Leu Ala Met Cys Val Val Val Arg Phe Leu Gly Arg Arg Gly Gly Leu 
                485                 490                 495     


Leu Leu Phe Met Ile Leu Thr Ala Leu Ala Ser Leu Leu Gln Leu Gly 
            500                 505                 510         


Leu Leu Asn Leu Ile Gly Lys Tyr Ser Gln His Pro Asp Ser Gly Met 
        515                 520                 525             


Ser Asp Ser Val Lys Asp Lys Phe Ser Ile Ala Phe Ser Ile Val Gly 
    530                 535                 540                 


Met Phe Ala Ser His Ala Val Gly Ser Leu Ser Val Phe Phe Cys Ala 
545                 550                 555                 560 


Glu Ile Thr Pro Thr Val Ile Arg Cys Gly Gly Leu Gly Leu Val Leu 
                565                 570                 575     


Ala Ser Ala Gly Phe Gly Met Leu Thr Ala Pro Ile Ile Glu Leu His 
            580                 585                 590         


Asn Gln Lys Gly Tyr Phe Leu His His Ile Ile Phe Ala Cys Cys Thr 
        595                 600                 605             


Leu Ile Cys Ile Ile Cys Ile Leu Leu Leu Pro Glu Ser Arg Asp Gln 
    610                 615                 620                 


Asn Leu Pro Glu Asn Ile Ser Asn Gly Glu His Tyr Thr Arg Gln Pro 
625                 630                 635                 640 


Leu Leu Pro His Lys Lys Gly Glu Gln Pro Leu Leu Leu Thr Asn Ala 
                645                 650                 655     


Glu Leu Lys Asp Tyr Ser Gly Leu His Asp Ala Ala Ala Ala Gly Asp 
            660                 665                 670         


Thr Leu Pro Glu Gly Ala Thr Ala Asn Gly Met Lys Ala Met 
        675                 680                 685     


<210>  4090
<211>  385
<212>  PRT
<213>  Homo sapiens

<400>  4090

Met Ala Ala Val Val Ala Ala Thr Ala Leu Lys Gly Arg Gly Ala Arg 
1               5                   10                  15      


Asn Ala Arg Val Leu Arg Gly Ile Leu Ala Gly Ala Thr Ala Asn Lys 
            20                  25                  30          


Ala Ser His Asn Arg Thr Arg Ala Leu Gln Ser His Ser Ser Pro Glu 
        35                  40                  45              


Gly Lys Glu Glu Pro Glu Pro Leu Ser Pro Glu Leu Glu Tyr Ile Pro 
    50                  55                  60                  


Arg Lys Arg Gly Lys Asn Pro Met Lys Ala Val Gly Leu Ala Trp Tyr 
65                  70                  75                  80  


Ser Leu Tyr Thr Arg Thr Trp Leu Gly Tyr Leu Phe Tyr Arg Gln Gln 
                85                  90                  95      


Leu Arg Arg Ala Arg Asn Arg Tyr Pro Lys Gly His Ser Lys Thr Gln 
            100                 105                 110         


Pro Arg Leu Phe Asn Gly Val Lys Val Leu Pro Ile Pro Val Leu Ser 
        115                 120                 125             


Asp Asn Tyr Ser Tyr Leu Ile Ile Asp Thr Gln Ala Gln Leu Ala Val 
    130                 135                 140                 


Ala Val Asp Pro Ser Asp Pro Arg Ala Val Gln Ala Ser Ile Glu Lys 
145                 150                 155                 160 


Glu Gly Val Thr Leu Val Ala Ile Leu Cys Thr His Lys His Trp Asp 
                165                 170                 175     


His Ser Gly Gly Asn Arg Asp Leu Ser Arg Arg His Arg Asp Cys Arg 
            180                 185                 190         


Val Tyr Gly Ser Pro Gln Asp Gly Ile Pro Tyr Leu Thr His Pro Leu 
        195                 200                 205             


Cys His Gln Asp Val Val Ser Val Gly Arg Leu Gln Ile Arg Ala Leu 
    210                 215                 220                 


Ala Thr Pro Gly His Thr Gln Gly His Leu Val Tyr Leu Leu Asp Gly 
225                 230                 235                 240 


Glu Pro Tyr Lys Gly Pro Ser Cys Leu Phe Ser Gly Asp Leu Leu Phe 
                245                 250                 255     


Leu Ser Gly Cys Gly Arg Thr Phe Glu Gly Asn Ala Glu Thr Met Leu 
            260                 265                 270         


Ser Ser Leu Asp Thr Val Leu Gly Leu Gly Asp Asp Thr Leu Leu Trp 
        275                 280                 285             


Pro Gly His Glu Tyr Ala Glu Glu Asn Leu Gly Phe Ala Gly Val Val 
    290                 295                 300                 


Glu Pro Glu Asn Leu Ala Arg Glu Arg Lys Met Gln Trp Val Gln Arg 
305                 310                 315                 320 


Gln Arg Leu Glu Arg Lys Gly Thr Cys Pro Ser Thr Leu Gly Glu Glu 
                325                 330                 335     


Arg Ser Tyr Asn Pro Phe Leu Arg Thr His Cys Leu Ala Leu Gln Glu 
            340                 345                 350         


Ala Leu Gly Pro Gly Pro Gly Pro Thr Gly Asp Asp Asp Tyr Ser Arg 
        355                 360                 365             


Ala Gln Leu Leu Glu Glu Leu Arg Arg Leu Lys Asp Met His Lys Ser 
    370                 375                 380                 


Lys 
385 


<210>  4091
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  4091

Met Ala Ala Ala Ala Trp Leu Gln Val Leu Pro Val Ile Leu Leu Leu 
1               5                   10                  15      


Leu Gly Ala His Pro Ser Pro Leu Ser Phe Phe Ser Ala Gly Pro Ala 
            20                  25                  30          


Thr Val Ala Ala Ala Asp Arg Ser Lys Trp His Ile Pro Ile Pro Ser 
        35                  40                  45              


Gly Lys Asn Tyr Phe Ser Phe Gly Lys Ile Leu Phe Arg Asn Thr Thr 
    50                  55                  60                  


Ile Phe Leu Lys Phe Asp Gly Glu Pro Cys Asp Leu Ser Leu Asn Ile 
65                  70                  75                  80  


Thr Trp Tyr Leu Lys Ser Ala Asp Cys Tyr Asn Glu Ile Tyr Asn Phe 
                85                  90                  95      


Lys Ala Glu Glu Val Glu Leu Tyr Leu Glu Lys Leu Lys Glu Lys Arg 
            100                 105                 110         


Gly Leu Ser Gly Lys Tyr Gln Thr Ser Ser Lys Leu Phe Gln Asn Cys 
        115                 120                 125             


Ser Glu Leu Phe Lys Thr Gln Thr Phe Ser Gly Asp Phe Met His Arg 
    130                 135                 140                 


Leu Pro Leu Leu Gly Glu Lys Gln Glu Ala Lys Glu Asn Gly Thr Asn 
145                 150                 155                 160 


Leu Thr Phe Ile Gly Asp Lys Thr Ala Met His Glu Pro Leu Gln Thr 
                165                 170                 175     


Trp Gln Asp Ala Pro Tyr Ile Phe Ile Val His Ile Gly Ile Ser Ser 
            180                 185                 190         


Ser Lys Glu Ser Ser Lys Glu Asn Ser Leu Ser Asn Leu Phe Thr Met 
        195                 200                 205             


Thr Val Glu Val Lys Gly Pro Tyr Glu Tyr Leu Thr Leu Glu Asp Tyr 
    210                 215                 220                 


Pro Leu Met Ile Phe Phe Met Val Met Cys Ile Val Tyr Val Leu Phe 
225                 230                 235                 240 


Gly Val Leu Trp Leu Ala Trp Ser Ala Cys Tyr Trp Arg Asp Leu Leu 
                245                 250                 255     


Arg Ile Gln Phe Trp Ile Gly Ala Val Ile Phe Leu Gly Met Leu Glu 
            260                 265                 270         


Lys Ala Val Phe Tyr Ala Glu Phe Gln Asn Ile Arg Tyr Lys Gly Glu 
        275                 280                 285             


Ser Val Gln Gly Ala Leu Ile Leu Ala Glu Leu Leu Ser Ala Val Lys 
    290                 295                 300                 


Arg Ser Leu Ala Arg Thr Leu Val Ile Ile Val Ser Leu Gly Tyr Gly 
305                 310                 315                 320 


Ile Val Lys Pro Arg Leu Gly Val Thr Leu His Lys Val Val Val Ala 
                325                 330                 335     


Gly Ala Leu Tyr Leu Leu Phe Ser Gly Met Glu Gly Val Leu Arg Val 
            340                 345                 350         


Thr Gly Ala Gln Thr Asp Leu Ala Ser Leu Ala Phe Ile Pro Leu Ala 
        355                 360                 365             


Phe Leu Asp Thr Ala Leu Cys Trp Trp Ile Phe Ile Ser Leu Thr Gln 
    370                 375                 380                 


Thr Met Lys Leu Leu Lys Leu Arg Arg Asn Ile Val Lys Leu Ser Leu 
385                 390                 395                 400 


Tyr Arg His Phe Thr Asn Thr Leu Ile Leu Ala Val Ala Ala Ser Ile 
                405                 410                 415     


Val Phe Ile Ile Trp Thr Thr Met Lys Phe Arg Ile Val Thr Cys Gln 
            420                 425                 430         


Ser Asp Trp Arg Glu Leu Trp Val Asp Asp Ala Ile Trp Arg Leu Leu 
        435                 440                 445             


Phe Ser Met Ile Leu Phe Val Ile Met Val Leu Trp Arg Pro Ser Ala 
    450                 455                 460                 


Asn Asn Gln Arg Phe Ala Phe Ser Pro Leu Ser Glu Glu Glu Glu Glu 
465                 470                 475                 480 


Asp Glu Gln Lys Glu Pro Met Leu Lys Glu Ser Phe Glu Gly Met Lys 
                485                 490                 495     


Met Arg Ser Thr Lys Gln Glu Pro Asn Gly Asn Ser Lys Val Asn Lys 
            500                 505                 510         


Ala Gln Glu Asp Asp Leu Lys Trp Val Glu Glu Asn Val Pro Ser Ser 
        515                 520                 525             


Val Thr Asp Val Ala Leu Pro Ala Leu Leu Asp Ser Asp Glu Glu Arg 
    530                 535                 540                 


Met Ile Thr His Phe Glu Arg Ser Lys Met Glu 
545                 550                 555 


<210>  4092
<211>  696
<212>  PRT
<213>  Homo sapiens

<400>  4092

Met Ala Met Ala Arg Leu Gly Ser Trp Leu Gly Glu Ala Gln Trp Leu 
1               5                   10                  15      


Ala Leu Val Ser Leu Phe Val Ala Ala Leu Ala Thr Val Gly Leu Tyr 
            20                  25                  30          


Leu Ala Gln Trp Ala Leu Ala Arg Ala Arg Pro Gln Pro Gln Arg Arg 
        35                  40                  45              


Ala Val Glu Pro Gly Glu Gly Pro Arg Pro Gly Ser Asp Ala Leu Leu 
    50                  55                  60                  


Ser Trp Ile Leu Thr Leu Gly Ser Trp Arg Ser Gln Trp Gln Ala Ala 
65                  70                  75                  80  


Trp Val Thr Ala Leu Asn Glu Glu Ala Glu Arg Lys Gly Gly Pro Pro 
                85                  90                  95      


Phe Leu Ser Phe Glu Glu Asp Pro Arg Gln Gln Ala Leu Glu Leu Val 
            100                 105                 110         


Val Gln Glu Val Ser Ser Val Leu Arg Ser Ala Glu Glu Lys Val Val 
        115                 120                 125             


Val Cys His Val Val Gly Gln Ala Ile Gln Phe Leu Val Ser Glu Thr 
    130                 135                 140                 


Pro Ala Leu Gly Ala Gly Cys Arg Leu Tyr Asp Met Arg Leu Ser Pro 
145                 150                 155                 160 


Phe His Leu Gln Leu Glu Phe His Met Lys Glu Lys Arg Glu Asp Leu 
                165                 170                 175     


Gln Ile Ser Trp Ser Phe Ile Ser Val Pro Glu Met Ala Val Asn Ile 
            180                 185                 190         


Gln Pro Lys Ala Leu Gly Glu Asp Gln Val Ala Glu Thr Ser Ala Met 
        195                 200                 205             


Ser Asp Val Leu Lys Asp Ile Leu Lys His Leu Ala Gly Ser Ala Ser 
    210                 215                 220                 


Pro Ser Val Val Leu Ile Thr Lys Pro Thr Thr Val Lys Glu Ala Gln 
225                 230                 235                 240 


Asn Leu Gln Cys Ala Ala Ser Thr Ala Gln Glu Ser Cys Pro Pro Lys 
                245                 250                 255     


Pro Pro Arg Ala His Glu Leu Lys Leu Leu Val Arg Asn Ile His Val 
            260                 265                 270         


Leu Leu Leu Ser Glu Pro Gly Ala Ser Gly His Ile Asn Ala Val Cys 
        275                 280                 285             


Val Val Gln Leu Asn Asp Pro Val Gln Arg Phe Ser Ser Thr Leu Thr 
    290                 295                 300                 


Lys Asn Thr Pro Asp Leu Met Trp Glu Glu Glu Phe Thr Phe Glu Leu 
305                 310                 315                 320 


Asn Ala Lys Ser Lys Glu Leu His Leu Gln Ile Ser Glu Ala Gly Arg 
                325                 330                 335     


Ser Ser Glu Gly Leu Leu Ala Thr Ala Thr Val Pro Leu Asp Leu Phe 
            340                 345                 350         


Lys Lys Gln Pro Ser Gly Pro Gln Ser Phe Thr Leu Thr Ser Gly Ser 
        355                 360                 365             


Ala Cys Gly Ser Ser Val Leu Gly Ser Val Thr Ala Glu Phe Ser Tyr 
    370                 375                 380                 


Met Glu Pro Gly Glu Leu Lys Ser Trp Pro Ile Pro Pro Pro Val Pro 
385                 390                 395                 400 


Ala Ala Lys Ile Glu Lys Asp Arg Thr Val Met Pro Cys Gly Thr Val 
                405                 410                 415     


Val Thr Thr Val Thr Ala Val Lys Thr Lys Pro Arg Val Asp Val Gly 
            420                 425                 430         


Arg Ala Ser Pro Leu Ser Ser Asp Ser Pro Val Lys Thr Pro Ile Lys 
        435                 440                 445             


Val Lys Val Ile Glu Lys Asp Ile Ser Val Gln Ala Ile Ala Cys Arg 
    450                 455                 460                 


Ser Ala Pro Val Ser Lys Thr Leu Ser Ser Ser Asp Thr Glu Leu Leu 
465                 470                 475                 480 


Val Leu Asn Gly Ser Asp Pro Val Ala Glu Val Ala Ile Arg Gln Leu 
                485                 490                 495     


Ser Glu Ser Ser Lys Leu Lys Leu Lys Ser Pro Arg Lys Lys Ser Thr 
            500                 505                 510         


Ile Ile Ile Ser Gly Ile Ser Lys Thr Ser Leu Ser Gln Asp His Asp 
        515                 520                 525             


Ala Ala Leu Met Gln Gly Tyr Thr Ala Ser Val Asp Ser Thr His Gln 
    530                 535                 540                 


Glu Asp Ala Pro Ser His Pro Glu Arg Ala Ala Ala Ser Ala Pro Pro 
545                 550                 555                 560 


Glu Glu Ala Glu Ser Ala Gln Ala Ser Leu Ala Pro Lys Pro Gln Glu 
                565                 570                 575     


Asp Glu Leu Asp Ser Trp Asp Leu Glu Lys Glu Pro Gln Ala Ala Ala 
            580                 585                 590         


Trp Ser Ser Gln Val Leu Leu Asp Pro Asp Gly Asp Glu Leu Ser Glu 
        595                 600                 605             


Ser Ser Met Ser Val Leu Glu Pro Gly Thr Ala Lys Lys His Lys Gly 
    610                 615                 620                 


Gly Ile Leu Arg Lys Gly Ala Lys Leu Phe Phe Arg Arg Arg His Gln 
625                 630                 635                 640 


Gln Lys Asp Pro Gly Met Ser Gln Ser His Asn Asp Leu Val Phe Leu 
                645                 650                 655     


Glu Gln Pro Glu Gly Ser Arg Arg Lys Gly Ile Thr Leu Thr Arg Ile 
            660                 665                 670         


Leu Asn Lys Lys Leu Leu Ser Arg His Arg Asn Lys Asn Thr Met Asn 
        675                 680                 685             


Gly Ala Pro Val Glu Pro Cys Thr 
    690                 695     


<210>  4093
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  4093

Met Val Ser Pro Ala Thr Arg Lys Ser Leu Pro Lys Val Lys Ala Met 
1               5                   10                  15      


Asp Phe Ile Thr Ser Thr Ala Ile Leu Pro Leu Leu Phe Gly Cys Leu 
            20                  25                  30          


Gly Val Phe Gly Leu Phe Arg Leu Leu Gln Trp Val Arg Gly Lys Ala 
        35                  40                  45              


Tyr Leu Arg Asn Ala Val Val Val Ile Thr Gly Ala Thr Ser Gly Leu 
    50                  55                  60                  


Gly Lys Glu Cys Ala Lys Val Phe Tyr Ala Ala Gly Ala Lys Leu Val 
65                  70                  75                  80  


Leu Cys Gly Arg Asn Gly Gly Ala Leu Glu Glu Leu Ile Arg Glu Leu 
                85                  90                  95      


Thr Ala Ser His Ala Thr Lys Val Gln Thr His Lys Pro Tyr Leu Val 
            100                 105                 110         


Thr Phe Asp Leu Thr Asp Ser Gly Ala Ile Val Ala Ala Ala Ala Glu 
        115                 120                 125             


Ile Leu Gln Cys Phe Gly Tyr Val Asp Ile Leu Val Asn Asn Ala Gly 
    130                 135                 140                 


Ile Ser Tyr Arg Gly Thr Ile Met Asp Thr Thr Val Asp Val Asp Lys 
145                 150                 155                 160 


Arg Val Met Glu Thr Asn Tyr Phe Gly Pro Val Ala Leu Thr Lys Ala 
                165                 170                 175     


Leu Leu Pro Ser Met Ile Lys Arg Arg Gln Gly His Ile Val Ala Ile 
            180                 185                 190         


Ser Ser Ile Gln Gly Lys Met Ser Ile Pro Phe Arg Ser Ala Tyr Ala 
        195                 200                 205             


Ala Ser Lys His Ala Thr Gln Ala Phe Phe Asp Cys Leu Arg Ala Glu 
    210                 215                 220                 


Met Glu Gln Tyr Glu Ile Glu Val Thr Val Ile Ser Pro Gly Tyr Ile 
225                 230                 235                 240 


His Thr Asn Leu Ser Val Asn Ala Ile Thr Ala Asp Gly Ser Arg Tyr 
                245                 250                 255     


Gly Val Met Asp Thr Thr Thr Ala Gln Gly Arg Ser Pro Val Glu Val 
            260                 265                 270         


Ala Gln Asp Val Leu Ala Ala Val Gly Lys Lys Lys Lys Asp Val Ile 
        275                 280                 285             


Leu Ala Asp Leu Leu Pro Ser Leu Ala Val Tyr Leu Arg Thr Leu Ala 
    290                 295                 300                 


Pro Gly Leu Phe Phe Ser Leu Met Ala Ser Arg Ala Arg Lys Glu Arg 
305                 310                 315                 320 


Lys Ser Lys Asn Ser 
                325 


<210>  4094
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  4094

Met Ala Pro Trp Pro Pro Lys Gly Leu Val Pro Ala Val Leu Trp Gly 
1               5                   10                  15      


Leu Ser Leu Phe Leu Asn Leu Pro Gly Pro Ile Trp Leu Gln Pro Ser 
            20                  25                  30          


Pro Pro Pro Gln Ser Ser Pro Pro Pro Gln Pro His Pro Cys His Thr 
        35                  40                  45              


Cys Arg Gly Leu Val Asp Ser Phe Asn Lys Gly Leu Glu Arg Thr Ile 
    50                  55                  60                  


Arg Asp Asn Phe Gly Gly Gly Asn Thr Ala Trp Glu Glu Glu Asn Leu 
65                  70                  75                  80  


Ser Lys Tyr Lys Asp Ser Glu Thr Arg Leu Val Glu Val Leu Glu Gly 
                85                  90                  95      


Val Cys Ser Lys Ser Asp Phe Glu Cys His Arg Leu Leu Glu Leu Ser 
            100                 105                 110         


Glu Glu Leu Val Glu Ser Trp Trp Phe His Lys Gln Gln Glu Ala Pro 
        115                 120                 125             


Asp Leu Phe Gln Trp Leu Cys Ser Asp Ser Leu Lys Leu Cys Cys Pro 
    130                 135                 140                 


Ala Gly Thr Phe Gly Pro Ser Cys Leu Pro Cys Pro Gly Gly Thr Glu 
145                 150                 155                 160 


Arg Pro Cys Gly Gly Tyr Gly Gln Cys Glu Gly Glu Gly Thr Arg Gly 
                165                 170                 175     


Gly Ser Gly His Cys Asp Cys Gln Ala Gly Tyr Gly Gly Glu Ala Cys 
            180                 185                 190         


Gly Gln Cys Gly Leu Gly Tyr Phe Glu Ala Glu Arg Asn Ala Ser His 
        195                 200                 205             


Leu Val Cys Ser Ala Cys Phe Gly Pro Cys Ala Arg Cys Ser Gly Pro 
    210                 215                 220                 


Glu Glu Ser Asn Cys Leu Gln Cys Lys Lys Gly Trp Ala Leu His His 
225                 230                 235                 240 


Leu Lys Cys Val Asp Ile Asp Glu Cys Gly Thr Glu Gly Ala Asn Cys 
                245                 250                 255     


Gly Ala Asp Gln Phe Cys Val Asn Thr Glu Gly Ser Tyr Glu Cys Arg 
            260                 265                 270         


Asp Cys Ala Lys Ala Cys Leu Gly Cys Met Gly Ala Gly Pro Gly Arg 
        275                 280                 285             


Cys Lys Lys Cys Ser Pro Gly Tyr Gln Gln Val Gly Ser Lys Cys Leu 
    290                 295                 300                 


Asp Val Asp Glu Cys Glu Thr Glu Val Cys Pro Gly Glu Asn Lys Gln 
305                 310                 315                 320 


Cys Glu Asn Thr Glu Gly Gly Tyr Arg Cys Ile Cys Ala Glu Gly Tyr 
                325                 330                 335     


Lys Gln Met Glu Gly Ile Cys Val Lys Glu Gln Ile Pro Glu Ser Ala 
            340                 345                 350         


Gly Phe Phe Ser Glu Met Thr Glu Asp Glu Leu Val Val Leu Gln Gln 
        355                 360                 365             


Met Phe Phe Gly Ile Ile Ile Cys Ala Leu Ala Thr Leu Ala Ala Lys 
    370                 375                 380                 


Gly Asp Leu Val Phe Thr Ala Ile Phe Ile Gly Ala Val Ala Ala Met 
385                 390                 395                 400 


Thr Gly Tyr Trp Leu Ser Glu Arg Ser Asp Arg Val Leu Glu Gly Phe 
                405                 410                 415     


Ile Lys Gly Arg 
            420 


<210>  4095
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  4095

Met His Pro Ala Ala Phe Pro Leu Pro Val Val Val Ala Ala Val Leu 
1               5                   10                  15      


Trp Gly Ala Ala Pro Thr Arg Gly Leu Ile Arg Ala Thr Ser Asp His 
            20                  25                  30          


Asn Ala Ser Met Asp Phe Ala Asp Leu Pro Ala Leu Phe Gly Ala Thr 
        35                  40                  45              


Leu Ser Gln Glu Gly Leu Gln Gly Phe Leu Val Glu Ala His Pro Asp 
    50                  55                  60                  


Asn Ala Cys Ser Pro Ile Ala Pro Pro Pro Pro Ala Pro Val Asn Gly 
65                  70                  75                  80  


Ser Val Phe Ile Ala Leu Leu Arg Arg Phe Asp Cys Asn Phe Asp Leu 
                85                  90                  95      


Lys Val Leu Asn Ala Gln Lys Ala Gly Tyr Gly Ala Ala Val Val His 
            100                 105                 110         


Asn Val Asn Ser Asn Glu Leu Leu Asn Met Val Trp Asn Ser Glu Glu 
        115                 120                 125             


Ile Gln Gln Gln Ile Trp Ile Pro Ser Val Phe Ile Gly Glu Arg Ser 
    130                 135                 140                 


Ser Glu Tyr Leu Arg Ala Leu Phe Val Tyr Glu Lys Gly Ala Arg Val 
145                 150                 155                 160 


Leu Leu Val Pro Asp Asn Thr Phe Pro Leu Gly Tyr Tyr Leu Ile Pro 
                165                 170                 175     


Phe Thr Gly Ile Val Gly Leu Leu Val Leu Ala Met Gly Ala Val Met 
            180                 185                 190         


Ile Ala Arg Cys Ile Gln His Arg Lys Arg Leu Gln Arg Asn Arg Leu 
        195                 200                 205             


Thr Lys Glu Gln Leu Lys Gln Ile Pro Thr His Asp Tyr Gln Lys Gly 
    210                 215                 220                 


Asp Gln Tyr Asp Val Cys Ala Ile Cys Leu Asp Glu Tyr Glu Asp Gly 
225                 230                 235                 240 


Asp Lys Leu Arg Val Leu Pro Cys Ala His Ala Tyr His Ser Arg Cys 
                245                 250                 255     


Val Asp Pro Trp Leu Thr Gln Thr Arg Lys Thr Cys Pro Ile Cys Lys 
            260                 265                 270         


Gln Pro Val His Arg Gly Pro Gly Asp Glu Asp Gln Glu Glu Glu Thr 
        275                 280                 285             


Gln Gly Gln Glu Glu Gly Asp Glu Gly Glu Pro Arg Asp His Pro Ala 
    290                 295                 300                 


Ser Glu Arg Thr Pro Leu Leu Gly Ser Ser Pro Thr Leu Pro Thr Ser 
305                 310                 315                 320 


Phe Gly Ser Leu Ala Pro Ala Pro Leu Val Phe Pro Gly Pro Ser Thr 
                325                 330                 335     


Asp Pro Pro Leu Ser Pro Pro Ser Ser Pro Val Ile Leu Val 
            340                 345                 350 


<210>  4096
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  4096

Met Thr Ser Lys Lys Leu Val Asn Ser Val Ala Gly Cys Ala Asp Asp 
1               5                   10                  15      


Ala Leu Ala Gly Leu Val Ala Cys Asn Pro Asn Leu Gln Leu Leu Gln 
            20                  25                  30          


Gly His Arg Val Ala Leu Arg Ser Asp Leu Asp Ser Leu Lys Gly Arg 
        35                  40                  45              


Val Ala Leu Leu Ser Gly Gly Gly Ser Gly His Glu Pro Ala His Ala 
    50                  55                  60                  


Gly Phe Ile Gly Lys Gly Met Leu Thr Gly Val Ile Ala Gly Ala Val 
65                  70                  75                  80  


Phe Thr Ser Pro Ala Val Gly Ser Ile Leu Ala Ala Ile Arg Ala Val 
                85                  90                  95      


Ala Gln Ala Gly Thr Val Gly Thr Leu Leu Ile Val Lys Asn Tyr Thr 
            100                 105                 110         


Gly Asp Arg Leu Asn Phe Gly Leu Ala Arg Glu Gln Ala Arg Ala Glu 
        115                 120                 125             


Gly Ile Pro Val Glu Met Val Val Ile Gly Asp Asp Ser Ala Phe Thr 
    130                 135                 140                 


Val Leu Lys Lys Ala Gly Arg Arg Gly Leu Cys Gly Thr Val Leu Ile 
145                 150                 155                 160 


His Lys Val Ala Gly Ala Leu Ala Glu Ala Gly Val Gly Leu Glu Glu 
                165                 170                 175     


Ile Ala Lys Gln Val Asn Val Val Ala Lys Ala Met Gly Thr Leu Gly 
            180                 185                 190         


Val Ser Leu Ser Ser Cys Ser Val Pro Gly Ser Lys Pro Thr Phe Glu 
        195                 200                 205             


Leu Ser Ala Asp Glu Val Glu Leu Gly Leu Gly Ile His Gly Glu Ala 
    210                 215                 220                 


Gly Val Arg Arg Ile Lys Met Ala Thr Ala Asp Glu Ile Val Lys Leu 
225                 230                 235                 240 


Met Leu Asp His Met Thr Asn Thr Thr Asn Ala Ser His Val Pro Val 
                245                 250                 255     


Gln Pro Gly Ser Ser Val Val Met Met Val Asn Asn Leu Gly Gly Leu 
            260                 265                 270         


Ser Phe Leu Glu Leu Gly Ile Ile Ala Asp Ala Thr Val Arg Ser Leu 
        275                 280                 285             


Glu Gly Arg Gly Val Lys Ile Ala Arg Ala Leu Val Gly Thr Phe Met 
    290                 295                 300                 


Ser Ala Leu Glu Met Pro Gly Ile Ser Leu Thr Leu Leu Leu Val Asp 
305                 310                 315                 320 


Glu Pro Leu Leu Lys Leu Ile Asp Ala Glu Thr Thr Ala Ala Ala Trp 
                325                 330                 335     


Pro Asn Val Ala Ala Val Ser Ile Thr Gly Arg Lys Arg Ser Arg Val 
            340                 345                 350         


Ala Pro Ala Glu Pro Gln Glu Ala Pro Asp Ser Thr Ala Ala Gly Gly 
        355                 360                 365             


Ser Ala Ser Lys Arg Met Ala Leu Val Leu Glu Arg Val Cys Ser Thr 
    370                 375                 380                 


Leu Leu Gly Leu Glu Glu His Leu Asn Ala Leu Asp Arg Ala Ala Gly 
385                 390                 395                 400 


Asp Gly Asp Cys Gly Thr Thr His Ser Arg Ala Ala Arg Ala Ile Gln 
                405                 410                 415     


Glu Trp Leu Lys Glu Gly Pro Pro Pro Ala Ser Pro Ala Gln Leu Leu 
            420                 425                 430         


Ser Lys Leu Ser Val Leu Leu Leu Glu Lys Met Gly Gly Ser Ser Gly 
        435                 440                 445             


Ala Leu Tyr Gly Leu Phe Leu Thr Ala Ala Ala Gln Pro Leu Lys Ala 
    450                 455                 460                 


Lys Thr Ser Leu Pro Ala Trp Ser Ala Ala Met Asp Ala Gly Leu Glu 
465                 470                 475                 480 


Ala Met Gln Lys Tyr Gly Lys Ala Ala Pro Gly Asp Arg Thr Met Leu 
                485                 490                 495     


Asp Ser Leu Trp Ala Ala Gly Gln Glu Leu Gln Ala Trp Lys Ser Pro 
            500                 505                 510         


Gly Ala Asp Leu Leu Gln Val Leu Thr Lys Ala Val Lys Ser Ala Glu 
        515                 520                 525             


Ala Ala Ala Glu Ala Thr Lys Asn Met Glu Ala Gly Ala Gly Arg Ala 
    530                 535                 540                 


Ser Tyr Ile Ser Ser Ala Arg Leu Glu Gln Pro Asp Pro Gly Ala Val 
545                 550                 555                 560 


Ala Ala Ala Ala Ile Leu Arg Ala Ile Leu Glu Val Leu Gln Ser 
                565                 570                 575 


<210>  4097
<211>  1093
<212>  PRT
<213>  Homo sapiens

<400>  4097

Met Ala Arg Pro Val Arg Gly Gly Leu Gly Ala Pro Arg Arg Ser Pro 
1               5                   10                  15      


Cys Leu Leu Leu Leu Trp Leu Leu Leu Leu Arg Leu Glu Pro Val Thr 
            20                  25                  30          


Ala Ala Ala Gly Pro Arg Ala Pro Cys Ala Ala Ala Cys Thr Cys Ala 
        35                  40                  45              


Gly Asp Ser Leu Asp Cys Gly Gly Arg Gly Leu Ala Ala Leu Pro Gly 
    50                  55                  60                  


Asp Leu Pro Ser Trp Thr Arg Ser Leu Asn Leu Ser Tyr Asn Lys Leu 
65                  70                  75                  80  


Ser Glu Ile Asp Pro Ala Gly Phe Glu Asp Leu Pro Asn Leu Gln Glu 
                85                  90                  95      


Val Tyr Leu Asn Asn Asn Glu Leu Thr Ala Val Pro Ser Leu Gly Ala 
            100                 105                 110         


Ala Ser Ser His Val Val Ser Leu Phe Leu Gln His Asn Lys Ile Arg 
        115                 120                 125             


Ser Val Glu Gly Ser Gln Leu Lys Ala Tyr Leu Ser Leu Glu Val Leu 
    130                 135                 140                 


Asp Leu Ser Leu Asn Asn Ile Thr Glu Val Arg Asn Thr Cys Phe Pro 
145                 150                 155                 160 


His Gly Pro Pro Ile Lys Glu Leu Asn Leu Ala Gly Asn Arg Ile Gly 
                165                 170                 175     


Thr Leu Glu Leu Gly Ala Phe Asp Gly Leu Ser Arg Ser Leu Leu Thr 
            180                 185                 190         


Leu Arg Leu Ser Lys Asn Arg Ile Thr Gln Leu Pro Val Arg Ala Phe 
        195                 200                 205             


Lys Leu Pro Arg Leu Thr Gln Leu Asp Leu Asn Arg Asn Arg Ile Arg 
    210                 215                 220                 


Leu Ile Glu Gly Leu Thr Phe Gln Gly Leu Asn Ser Leu Glu Val Leu 
225                 230                 235                 240 


Lys Leu Gln Arg Asn Asn Ile Ser Lys Leu Thr Asp Gly Ala Phe Trp 
                245                 250                 255     


Gly Leu Ser Lys Met His Val Leu His Leu Glu Tyr Asn Ser Leu Val 
            260                 265                 270         


Glu Val Asn Ser Gly Ser Leu Tyr Gly Leu Thr Ala Leu His Gln Leu 
        275                 280                 285             


His Leu Ser Asn Asn Ser Ile Ala Arg Ile His Arg Lys Gly Trp Ser 
    290                 295                 300                 


Phe Cys Gln Lys Leu His Glu Leu Val Leu Ser Phe Asn Asn Leu Thr 
305                 310                 315                 320 


Arg Leu Asp Glu Glu Ser Leu Ala Glu Leu Ser Ser Leu Ser Val Leu 
                325                 330                 335     


Arg Leu Ser His Asn Ser Ile Ser His Ile Ala Glu Gly Ala Phe Lys 
            340                 345                 350         


Gly Leu Arg Ser Leu Arg Val Leu Asp Leu Asp His Asn Glu Ile Ser 
        355                 360                 365             


Gly Thr Ile Glu Asp Thr Ser Gly Ala Phe Ser Gly Leu Asp Ser Leu 
    370                 375                 380                 


Ser Lys Leu Thr Leu Phe Gly Asn Lys Ile Lys Ser Val Ala Lys Arg 
385                 390                 395                 400 


Ala Phe Ser Gly Leu Glu Gly Leu Glu His Leu Asn Leu Gly Gly Asn 
                405                 410                 415     


Ala Ile Arg Ser Val Gln Phe Asp Ala Phe Val Lys Met Lys Asn Leu 
            420                 425                 430         


Lys Glu Leu His Ile Ser Ser Asp Ser Phe Leu Cys Asp Cys Gln Leu 
        435                 440                 445             


Lys Trp Leu Pro Pro Trp Leu Ile Gly Arg Met Leu Gln Ala Phe Val 
    450                 455                 460                 


Thr Ala Thr Cys Ala His Pro Glu Ser Leu Lys Gly Gln Ser Ile Phe 
465                 470                 475                 480 


Ser Val Pro Pro Glu Ser Phe Val Cys Asp Asp Phe Leu Lys Pro Gln 
                485                 490                 495     


Ile Ile Thr Gln Pro Glu Thr Thr Met Ala Met Val Gly Lys Asp Ile 
            500                 505                 510         


Arg Phe Thr Cys Ser Ala Ala Ser Ser Ser Ser Ser Pro Met Thr Phe 
        515                 520                 525             


Ala Trp Lys Lys Asp Asn Glu Val Leu Thr Asn Ala Asp Met Glu Asn 
    530                 535                 540                 


Phe Val His Val His Ala Gln Asp Gly Glu Val Met Glu Tyr Thr Thr 
545                 550                 555                 560 


Ile Leu His Leu Arg Gln Val Thr Phe Gly His Glu Gly Arg Tyr Gln 
                565                 570                 575     


Cys Val Ile Thr Asn His Phe Gly Ser Thr Tyr Ser His Lys Ala Arg 
            580                 585                 590         


Leu Thr Val Asn Val Leu Pro Ser Phe Thr Lys Thr Pro His Asp Ile 
        595                 600                 605             


Thr Ile Arg Thr Thr Thr Met Ala Arg Leu Glu Cys Ala Ala Thr Gly 
    610                 615                 620                 


His Pro Asn Pro Gln Ile Ala Trp Gln Lys Asp Gly Gly Thr Asp Phe 
625                 630                 635                 640 


Pro Ala Ala Arg Glu Arg Arg Met His Val Met Pro Asp Asp Asp Val 
                645                 650                 655     


Phe Phe Ile Thr Asp Val Lys Ile Asp Asp Ala Gly Val Tyr Ser Cys 
            660                 665                 670         


Thr Ala Gln Asn Ser Ala Gly Ser Ile Ser Ala Asn Ala Thr Leu Thr 
        675                 680                 685             


Val Leu Glu Thr Pro Ser Leu Val Val Pro Leu Glu Asp Arg Val Val 
    690                 695                 700                 


Ser Val Gly Glu Thr Val Ala Leu Gln Cys Lys Ala Thr Gly Asn Pro 
705                 710                 715                 720 


Pro Pro Arg Ile Thr Trp Phe Lys Gly Asp Arg Pro Leu Ser Leu Thr 
                725                 730                 735     


Glu Arg His His Leu Thr Pro Asp Asn Gln Leu Leu Val Val Gln Asn 
            740                 745                 750         


Val Val Ala Glu Asp Ala Gly Arg Tyr Thr Cys Glu Met Ser Asn Thr 
        755                 760                 765             


Leu Gly Thr Glu Arg Ala His Ser Gln Leu Ser Val Leu Pro Ala Ala 
    770                 775                 780                 


Gly Cys Arg Lys Asp Gly Thr Thr Val Gly Ile Phe Thr Ile Ala Val 
785                 790                 795                 800 


Val Ser Ser Ile Val Leu Thr Ser Leu Val Trp Val Cys Ile Ile Tyr 
                805                 810                 815     


Gln Thr Arg Lys Lys Ser Glu Glu Tyr Ser Val Thr Asn Thr Asp Glu 
            820                 825                 830         


Thr Val Val Pro Pro Asp Val Pro Ser Tyr Leu Ser Ser Gln Gly Thr 
        835                 840                 845             


Leu Ser Asp Arg Gln Glu Thr Val Val Arg Thr Glu Gly Gly Pro Gln 
    850                 855                 860                 


Ala Asn Gly His Ile Glu Ser Asn Gly Val Cys Pro Arg Asp Ala Ser 
865                 870                 875                 880 


His Phe Pro Glu Pro Asp Thr His Ser Val Ala Cys Arg Gln Pro Lys 
                885                 890                 895     


Leu Cys Ala Gly Ser Ala Tyr His Lys Glu Pro Trp Lys Ala Met Glu 
            900                 905                 910         


Lys Ala Glu Gly Thr Pro Gly Pro His Lys Met Glu His Gly Gly Arg 
        915                 920                 925             


Val Val Cys Ser Asp Cys Asn Thr Glu Val Asp Cys Tyr Ser Arg Gly 
    930                 935                 940                 


Gln Ala Phe His Pro Gln Pro Val Ser Arg Asp Ser Ala Gln Pro Ser 
945                 950                 955                 960 


Ala Pro Asn Gly Pro Glu Pro Gly Gly Ser Asp Gln Glu His Ser Pro 
                965                 970                 975     


His His Gln Cys Ser Arg Thr Ala Ala Gly Ser Cys Pro Glu Cys Gln 
            980                 985                 990         


Gly Ser Leu Tyr Pro Ser Asn His  Asp Arg Met Leu Thr  Ala Val Lys 
        995                 1000                 1005             


Lys Lys  Pro Met Ala Ser Leu  Asp Gly Lys Gly Asp  Ser Ser Trp 
    1010                 1015                 1020             


Thr Leu  Ala Arg Leu Tyr His  Pro Asp Ser Thr Glu  Leu Gln Pro 
    1025                 1030                 1035             


Ala Ser  Ser Leu Thr Ser Gly  Ser Pro Glu Arg Ala  Glu Ala Gln 
    1040                 1045                 1050             


Tyr Leu  Leu Val Ser Asn Gly  His Leu Pro Lys Ala  Cys Asp Ala 
    1055                 1060                 1065             


Ser Pro  Glu Ser Thr Pro Leu  Thr Gly Gln Leu Pro  Gly Lys Gln 
    1070                 1075                 1080             


Arg Val  Pro Leu Leu Leu Ala  Pro Lys Ser 
    1085                 1090             


<210>  4098
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  4098

Met Glu Thr Val Val Ile Val Ala Ile Gly Val Leu Ala Thr Ile Phe 
1               5                   10                  15      


Leu Ala Ser Phe Ala Ala Leu Val Leu Val Cys Arg Gln Arg Tyr Cys 
            20                  25                  30          


Arg Pro Arg Asp Leu Leu Gln Arg Tyr Asp Ser Lys Pro Ile Val Asp 
        35                  40                  45              


Leu Ile Gly Ala Met Glu Thr Gln Ser Glu Pro Ser Glu Leu Glu Leu 
    50                  55                  60                  


Asp Asp Val Val Ile Thr Asn Pro His Ile Glu Ala Ile Leu Glu Asn 
65                  70                  75                  80  


Glu Asp Trp Ile Glu Asp Ala Ser Gly Leu Met Ser His Cys Ile Ala 
                85                  90                  95      


Ile Leu Lys Ile Cys His Thr Leu Thr Glu Lys Leu Val Ala Met Thr 
            100                 105                 110         


Met Gly Ser Gly Ala Lys Met Lys Thr Ser Ala Ser Val Ser Asp Ile 
        115                 120                 125             


Ile Val Val Ala Lys Arg Ile Ser Pro Arg Val Asp Asp Val Val Lys 
    130                 135                 140                 


Ser Met Tyr Pro Pro Leu Asp Pro Lys Leu Leu Asp Ala Arg Thr Thr 
145                 150                 155                 160 


Ala Leu Leu Leu Ser Val Ser His Leu Val Leu Val Thr Arg Asn Ala 
                165                 170                 175     


Cys His Leu Thr Gly Gly Leu Asp Trp Ile Asp Gln Ser Leu Ser Ala 
            180                 185                 190         


Ala Glu Glu His Leu Glu Val Leu Arg Glu Ala Ala Leu Ala Ser Glu 
        195                 200                 205             


Pro Asp Lys Gly Leu Pro Gly Pro Glu Gly Phe Leu Gln Glu Gln Ser 
    210                 215                 220                 


Ala Ile 
225     


<210>  4099
<211>  5171
<212>  PRT
<213>  Homo sapiens

<400>  4099

Met His Ser Ser Ser Tyr Ser Tyr Arg Ser Ser Asp Ser Val Phe Ser 
1               5                   10                  15      


Asn Thr Thr Ser Thr Arg Thr Ser Leu Asp Ser Asn Glu Asn Leu Leu 
            20                  25                  30          


Leu Val His Cys Gly Pro Thr Leu Ile Asn Ser Cys Ile Ser Phe Gly 
        35                  40                  45              


Ser Glu Ser Phe Asp Gly His Arg Leu Glu Met Leu Gln Gln Ile Ala 
    50                  55                  60                  


Asn Arg Val Gln Arg Asp Ser Val Ile Cys Glu Asp Lys Leu Ile Leu 
65                  70                  75                  80  


Ala Gly Asn Ala Leu Gln Ser Asp Ser Lys Arg Leu Glu Ser Gly Val 
                85                  90                  95      


Gln Phe Gln Asn Glu Ala Glu Ile Ala Gly Tyr Ile Leu Glu Cys Glu 
            100                 105                 110         


Asn Leu Leu Arg Gln His Val Ile Asp Val Gln Ile Leu Ile Asp Gly 
        115                 120                 125             


Lys Tyr Tyr Gln Ala Asp Gln Leu Val Gln Arg Val Ala Lys Leu Arg 
    130                 135                 140                 


Asp Glu Ile Met Ala Leu Arg Asn Glu Cys Ser Ser Val Tyr Ser Lys 
145                 150                 155                 160 


Gly Arg Ile Leu Thr Thr Glu Gln Thr Lys Leu Met Ile Ser Gly Ile 
                165                 170                 175     


Thr Gln Ser Leu Asn Ser Gly Phe Ala Gln Thr Leu His Pro Ser Leu 
            180                 185                 190         


Thr Ser Gly Leu Thr Gln Ser Leu Thr Pro Ser Leu Thr Ser Ser Ser 
        195                 200                 205             


Met Thr Ser Gly Leu Ser Ser Gly Met Thr Ser Arg Leu Thr Pro Ser 
    210                 215                 220                 


Val Thr Pro Ala Tyr Thr Pro Gly Phe Pro Ser Gly Leu Val Pro Asn 
225                 230                 235                 240 


Phe Ser Ser Gly Val Glu Pro Asn Ser Leu Gln Thr Leu Lys Leu Met 
                245                 250                 255     


Gln Ile Arg Lys Pro Leu Leu Lys Ser Ser Leu Leu Asp Gln Asn Leu 
            260                 265                 270         


Thr Glu Glu Glu Ile Asn Met Lys Phe Val Gln Asp Leu Leu Asn Trp 
        275                 280                 285             


Val Asp Glu Met Gln Val Gln Leu Asp Arg Thr Glu Trp Gly Ser Asp 
    290                 295                 300                 


Leu Pro Ser Val Glu Ser His Leu Glu Asn His Lys Asn Val His Arg 
305                 310                 315                 320 


Ala Ile Glu Glu Phe Glu Ser Ser Leu Lys Glu Ala Lys Ile Ser Glu 
                325                 330                 335     


Ile Gln Met Thr Ala Pro Leu Lys Leu Thr Tyr Ala Glu Lys Leu His 
            340                 345                 350         


Arg Leu Glu Ser Gln Tyr Ala Lys Leu Leu Asn Thr Ser Arg Asn Gln 
        355                 360                 365             


Glu Arg His Leu Asp Thr Leu His Asn Phe Val Ser Arg Ala Thr Asn 
    370                 375                 380                 


Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu Val Ala Tyr Asp 
385                 390                 395                 400 


Trp Ser Glu Arg Asn Thr Asn Ile Ala Arg Lys Lys Asp Tyr His Ala 
                405                 410                 415     


Glu Leu Met Arg Glu Leu Asp Gln Lys Glu Glu Asn Ile Lys Ser Val 
            420                 425                 430         


Gln Glu Ile Ala Glu Gln Leu Leu Leu Glu Asn His Pro Ala Arg Leu 
        435                 440                 445             


Thr Ile Glu Ala Tyr Arg Ala Ala Met Gln Thr Gln Trp Ser Trp Ile 
    450                 455                 460                 


Leu Gln Leu Cys Gln Cys Val Glu Gln His Ile Lys Glu Asn Thr Ala 
465                 470                 475                 480 


Tyr Phe Glu Phe Phe Asn Asp Ala Lys Glu Ala Thr Asp Tyr Leu Arg 
                485                 490                 495     


Asn Leu Lys Asp Ala Ile Gln Arg Lys Tyr Ser Cys Asp Arg Ser Ser 
            500                 505                 510         


Ser Ile His Lys Leu Glu Asp Leu Val Gln Glu Ser Met Glu Glu Lys 
        515                 520                 525             


Glu Glu Leu Leu Gln Tyr Lys Ser Thr Ile Ala Asn Leu Met Gly Lys 
    530                 535                 540                 


Ala Lys Thr Ile Ile Gln Leu Lys Pro Arg Asn Ser Asp Cys Pro Leu 
545                 550                 555                 560 


Lys Thr Ser Ile Pro Ile Lys Ala Ile Cys Asp Tyr Arg Gln Ile Glu 
                565                 570                 575     


Ile Thr Ile Tyr Lys Asp Asp Glu Cys Val Leu Ala Asn Asn Ser His 
            580                 585                 590         


Arg Ala Lys Trp Lys Val Ile Ser Pro Thr Gly Asn Glu Ala Met Val 
        595                 600                 605             


Pro Ser Val Cys Phe Thr Val Pro Pro Pro Asn Lys Glu Ala Val Asp 
    610                 615                 620                 


Leu Ala Asn Arg Ile Glu Gln Gln Tyr Gln Asn Val Leu Thr Leu Trp 
625                 630                 635                 640 


His Glu Ser His Ile Asn Met Lys Ser Val Val Ser Trp His Tyr Leu 
                645                 650                 655     


Ile Asn Glu Ile Asp Arg Ile Arg Ala Ser Asn Val Ala Ser Ile Lys 
            660                 665                 670         


Thr Met Leu Pro Gly Glu His Gln Gln Val Leu Ser Asn Leu Gln Ser 
        675                 680                 685             


Arg Phe Glu Asp Phe Leu Glu Asp Ser Gln Glu Ser Gln Val Phe Ser 
    690                 695                 700                 


Gly Ser Asp Ile Thr Gln Leu Glu Lys Glu Val Asn Val Cys Lys Gln 
705                 710                 715                 720 


Tyr Tyr Gln Glu Leu Leu Lys Ser Ala Glu Arg Glu Glu Gln Glu Glu 
                725                 730                 735     


Ser Val Tyr Asn Leu Tyr Ile Ser Glu Val Arg Asn Ile Arg Leu Arg 
            740                 745                 750         


Leu Glu Asn Cys Glu Asp Arg Leu Ile Arg Gln Ile Arg Thr Pro Leu 
        755                 760                 765             


Glu Arg Asp Asp Leu His Glu Ser Val Phe Arg Ile Thr Glu Gln Glu 
    770                 775                 780                 


Lys Leu Lys Lys Glu Leu Glu Arg Leu Lys Asp Asp Leu Gly Thr Ile 
785                 790                 795                 800 


Thr Asn Lys Cys Glu Glu Phe Phe Ser Gln Ala Ala Ala Ser Ser Ser 
                805                 810                 815     


Val Pro Thr Leu Arg Ser Glu Leu Asn Val Val Leu Gln Asn Met Asn 
            820                 825                 830         


Gln Val Tyr Ser Met Ser Ser Thr Tyr Ile Asp Lys Leu Lys Thr Val 
        835                 840                 845             


Asn Leu Val Leu Lys Asn Thr Gln Ala Ala Glu Ala Leu Val Lys Leu 
    850                 855                 860                 


Tyr Glu Thr Lys Leu Cys Glu Glu Glu Ala Val Ile Ala Asp Lys Asn 
865                 870                 875                 880 


Asn Ile Glu Asn Leu Ile Ser Thr Leu Lys Gln Trp Arg Ser Glu Val 
                885                 890                 895     


Asp Glu Lys Arg Gln Val Phe His Ala Leu Glu Asp Glu Leu Gln Lys 
            900                 905                 910         


Ala Lys Ala Ile Ser Asp Glu Met Phe Lys Thr Tyr Lys Glu Arg Asp 
        915                 920                 925             


Leu Asp Phe Asp Trp His Lys Glu Lys Ala Asp Gln Leu Val Glu Arg 
    930                 935                 940                 


Trp Gln Asn Val His Val Gln Ile Asp Asn Arg Leu Arg Asp Leu Glu 
945                 950                 955                 960 


Gly Ile Gly Lys Ser Leu Lys Tyr Tyr Arg Asp Thr Tyr His Pro Leu 
                965                 970                 975     


Asp Asp Trp Ile Gln Gln Val Glu Thr Thr Gln Arg Lys Ile Gln Glu 
            980                 985                 990         


Asn Gln Pro Glu Asn Ser Lys Thr  Leu Ala Thr Gln Leu  Asn Gln Gln 
        995                 1000                 1005             


Lys Met  Leu Val Ser Glu Ile  Glu Met Lys Gln Ser  Lys Met Asp 
    1010                 1015                 1020             


Glu Cys  Gln Lys Tyr Ala Glu  Gln Tyr Ser Ala Thr  Val Lys Asp 
    1025                 1030                 1035             


Tyr Glu  Leu Gln Thr Met Thr  Tyr Arg Ala Met Val  Asp Ser Gln 
    1040                 1045                 1050             


Gln Lys  Ser Pro Val Lys Arg  Arg Arg Met Gln Ser  Ser Ala Asp 
    1055                 1060                 1065             


Leu Ile  Ile Gln Glu Phe Met  Asp Leu Arg Thr Arg  Tyr Thr Ala 
    1070                 1075                 1080             


Leu Val  Thr Leu Met Thr Gln  Tyr Ile Lys Phe Ala  Gly Asp Ser 
    1085                 1090                 1095             


Leu Lys  Arg Leu Glu Glu Glu  Glu Lys Ser Leu Glu  Glu Glu Lys 
    1100                 1105                 1110             


Lys Glu  His Val Glu Lys Ala  Lys Glu Leu Gln Lys  Trp Val Ser 
    1115                 1120                 1125             


Asn Ile  Ser Lys Thr Leu Lys  Asp Ala Glu Lys Ala  Gly Lys Pro 
    1130                 1135                 1140             


Pro Phe  Ser Lys Gln Lys Ile  Ser Ser Glu Glu Ile  Ser Thr Lys 
    1145                 1150                 1155             


Lys Glu  Gln Leu Ser Glu Ala  Leu Gln Thr Ile Gln  Leu Phe Leu 
    1160                 1165                 1170             


Ala Lys  His Gly Asp Lys Met  Thr Asp Glu Glu Arg  Asn Glu Leu 
    1175                 1180                 1185             


Glu Lys  Gln Val Lys Thr Leu  Gln Glu Ser Tyr Asn  Leu Leu Phe 
    1190                 1195                 1200             


Ser Glu  Ser Leu Lys Gln Leu  Gln Glu Ser Gln Thr  Ser Gly Asp 
    1205                 1210                 1215             


Val Lys  Val Glu Glu Lys Ile  Val Ala Glu Arg Gln  Gln Glu Tyr 
    1220                 1225                 1230             


Lys Glu  Lys Leu Gln Gly Ile  Cys Asp Leu Leu Thr  Gln Thr Glu 
    1235                 1240                 1245             


Asn Arg  Leu Ile Gly His Gln  Glu Ala Phe Met Ile  Gly Asp Gly 
    1250                 1255                 1260             


Thr Val  Glu Leu Lys Lys Tyr  Gln Ser Lys Gln Glu  Glu Leu Gln 
    1265                 1270                 1275             


Lys Asp  Met Gln Gly Ser Ala  Gln Ala Leu Ala Glu  Val Val Lys 
    1280                 1285                 1290             


Asn Thr  Glu Asn Phe Leu Lys  Glu Asn Gly Glu Lys  Leu Ser Gln 
    1295                 1300                 1305             


Glu Asp  Lys Ala Leu Ile Glu  Gln Lys Leu Asn Glu  Ala Lys Ile 
    1310                 1315                 1320             


Lys Cys  Glu Gln Leu Asn Leu  Lys Ala Glu Gln Ser  Lys Lys Glu 
    1325                 1330                 1335             


Leu Asp  Lys Val Val Thr Thr  Ala Ile Lys Glu Glu  Thr Glu Lys 
    1340                 1345                 1350             


Val Ala  Ala Val Lys Gln Leu  Glu Glu Ser Lys Thr  Lys Ile Glu 
    1355                 1360                 1365             


Asn Leu  Leu Asp Trp Leu Ser  Asn Val Asp Lys Asp  Ser Glu Arg 
    1370                 1375                 1380             


Ala Gly  Thr Lys His Lys Gln  Val Ile Glu Gln Asn  Gly Thr His 
    1385                 1390                 1395             


Phe Gln  Glu Gly Asp Gly Lys  Ser Ala Ile Gly Glu  Glu Asp Glu 
    1400                 1405                 1410             


Val Asn  Gly Asn Leu Leu Glu  Thr Asp Val Asp Gly  Gln Val Gly 
    1415                 1420                 1425             


Thr Thr  Gln Glu Asn Leu Asn  Gln Gln Tyr Gln Lys  Val Lys Ala 
    1430                 1435                 1440             


Gln His  Glu Lys Ile Ile Ser  Gln His Gln Ala Val  Ile Ile Ala 
    1445                 1450                 1455             


Thr Gln  Ser Ala Gln Val Leu  Leu Glu Lys Gln Gly  Gln Tyr Leu 
    1460                 1465                 1470             


Ser Pro  Glu Glu Lys Glu Lys  Leu Gln Lys Asn Met  Lys Glu Leu 
    1475                 1480                 1485             


Lys Val  His Tyr Glu Thr Ala  Leu Ala Glu Ser Glu  Lys Lys Met 
    1490                 1495                 1500             


Lys Leu  Thr His Ser Leu Gln  Glu Glu Leu Glu Lys  Phe Asp Ala 
    1505                 1510                 1515             


Asp Tyr  Thr Glu Phe Glu His  Trp Leu Gln Gln Ser  Glu Gln Glu 
    1520                 1525                 1530             


Leu Glu  Asn Leu Glu Ala Gly  Ala Asp Asp Ile Asn  Gly Leu Met 
    1535                 1540                 1545             


Thr Lys  Leu Lys Arg Gln Lys  Ser Phe Ser Glu Asp  Val Ile Ser 
    1550                 1555                 1560             


His Lys  Gly Asp Leu Arg Tyr  Ile Thr Ile Ser Gly  Asn Arg Val 
    1565                 1570                 1575             


Leu Glu  Ala Ala Lys Ser Cys  Ser Lys Arg Asp Gly  Gly Lys Val 
    1580                 1585                 1590             


Asp Thr  Ser Ala Thr His Arg  Glu Val Gln Arg Lys  Leu Asp His 
    1595                 1600                 1605             


Ala Thr  Asp Arg Phe Arg Ser  Leu Tyr Ser Lys Cys  Asn Val Leu 
    1610                 1615                 1620             


Gly Asn  Asn Leu Lys Asp Leu  Val Asp Lys Tyr Gln  His Tyr Glu 
    1625                 1630                 1635             


Asp Ala  Ser Cys Gly Leu Leu  Ala Gly Leu Gln Ala  Cys Glu Ala 
    1640                 1645                 1650             


Thr Ala  Ser Lys His Leu Ser  Glu Pro Ile Ala Val  Asp Pro Lys 
    1655                 1660                 1665             


Asn Leu  Gln Arg Gln Leu Glu  Glu Thr Lys Ala Leu  Gln Gly Gln 
    1670                 1675                 1680             


Ile Ser  Ser Gln Gln Val Ala  Val Glu Lys Leu Lys  Lys Thr Ala 
    1685                 1690                 1695             


Glu Val  Leu Leu Asp Ala Arg  Gly Ser Leu Leu Pro  Ala Lys Asn 
    1700                 1705                 1710             


Asp Ile  Gln Lys Thr Leu Asp  Asp Ile Val Gly Arg  Tyr Glu Asp 
    1715                 1720                 1725             


Leu Ser  Lys Ser Val Asn Glu  Arg Asn Glu Lys Leu  Gln Ile Thr 
    1730                 1735                 1740             


Leu Thr  Arg Ser Leu Ser Val  Gln Asp Gly Leu Asp  Glu Met Leu 
    1745                 1750                 1755             


Asp Trp  Met Gly Asn Val Glu  Ser Ser Leu Lys Glu  Gln Gly Gln 
    1760                 1765                 1770             


Val Pro  Leu Asn Ser Thr Ala  Leu Gln Asp Ile Ile  Ser Lys Asn 
    1775                 1780                 1785             


Ile Met  Leu Glu Gln Asp Ile  Ala Gly Arg Gln Ser  Ser Ile Asn 
    1790                 1795                 1800             


Ala Met  Asn Glu Lys Val Lys  Lys Phe Met Glu Thr  Thr Asp Pro 
    1805                 1810                 1815             


Ser Thr  Ala Ser Ser Leu Gln  Ala Lys Met Lys Asp  Leu Ser Ala 
    1820                 1825                 1830             


Arg Phe  Ser Glu Ala Ser His  Lys His Lys Glu Thr  Leu Ala Lys 
    1835                 1840                 1845             


Met Glu  Glu Leu Lys Thr Lys  Val Glu Leu Phe Glu  Asn Leu Ser 
    1850                 1855                 1860             


Glu Lys  Leu Gln Thr Phe Leu  Glu Thr Lys Thr Gln  Ala Leu Thr 
    1865                 1870                 1875             


Glu Val  Asp Val Pro Gly Lys  Asp Val Thr Glu Leu  Ser Gln Tyr 
    1880                 1885                 1890             


Met Gln  Glu Ser Thr Ser Glu  Phe Leu Glu His Lys  Lys His Leu 
    1895                 1900                 1905             


Glu Val  Leu His Ser Leu Leu  Lys Glu Ile Ser Ser  His Gly Leu 
    1910                 1915                 1920             


Pro Ser  Asp Lys Ala Leu Val  Leu Glu Lys Thr Asn  Asn Leu Ser 
    1925                 1930                 1935             


Lys Lys  Phe Lys Glu Met Glu  Asp Thr Ile Lys Glu  Lys Lys Glu 
    1940                 1945                 1950             


Ala Val  Thr Ser Cys Gln Glu  Gln Leu Asp Ala Phe  Gln Val Leu 
    1955                 1960                 1965             


Val Lys  Ser Leu Lys Ser Trp  Ile Lys Glu Thr Thr  Lys Lys Val 
    1970                 1975                 1980             


Pro Ile  Val Gln Pro Ser Phe  Gly Ala Glu Asp Leu  Gly Lys Ser 
    1985                 1990                 1995             


Leu Glu  Asp Thr Lys Lys Leu  Gln Glu Lys Trp Ser  Leu Lys Thr 
    2000                 2005                 2010             


Pro Glu  Ile Gln Lys Val Asn  Asn Ser Gly Ile Ser  Leu Cys Asn 
    2015                 2020                 2025             


Leu Ile  Ser Ala Val Thr Thr  Pro Ala Lys Ala Ile  Ala Ala Val 
    2030                 2035                 2040             


Lys Ser  Gly Gly Ala Val Leu  Asn Gly Glu Gly Thr  Ala Thr Asn 
    2045                 2050                 2055             


Thr Glu  Glu Phe Trp Ala Asn  Lys Gly Leu Thr Ser  Ile Lys Lys 
    2060                 2065                 2070             


Asp Met  Thr Asp Ile Ser His  Gly Tyr Glu Asp Leu  Gly Leu Leu 
    2075                 2080                 2085             


Leu Lys  Asp Lys Ile Ala Glu  Leu Asn Thr Lys Leu  Ser Lys Leu 
    2090                 2095                 2100             


Gln Lys  Ala Gln Glu Glu Ser  Ser Ala Met Met Gln  Trp Leu Gln 
    2105                 2110                 2115             


Lys Met  Asn Lys Thr Ala Thr  Lys Trp Gln Gln Thr  Pro Ala Pro 
    2120                 2125                 2130             


Thr Asp  Thr Glu Ala Val Lys  Thr Gln Val Glu Gln  Asn Lys Ser 
    2135                 2140                 2145             


Phe Glu  Ala Glu Leu Lys Gln  Asn Val Asn Lys Val  Gln Glu Leu 
    2150                 2155                 2160             


Lys Asp  Lys Leu Thr Glu Leu  Leu Glu Glu Asn Pro  Asp Thr Pro 
    2165                 2170                 2175             


Glu Ala  Pro Arg Trp Lys Gln  Met Leu Thr Glu Ile  Asp Ser Lys 
    2180                 2185                 2190             


Trp Gln  Glu Leu Asn Gln Leu  Thr Ile Asp Arg Gln  Gln Lys Leu 
    2195                 2200                 2205             


Glu Glu  Ser Ser Asn Asn Leu  Thr Gln Phe Gln Thr  Val Glu Ala 
    2210                 2215                 2220             


Gln Leu  Lys Gln Trp Leu Val  Glu Lys Glu Leu Met  Val Ser Val 
    2225                 2230                 2235             


Leu Gly  Pro Leu Ser Ile Asp  Pro Asn Met Leu Asn  Thr Gln Arg 
    2240                 2245                 2250             


Gln Gln  Val Gln Ile Leu Leu  Gln Glu Phe Ala Thr  Arg Lys Pro 
    2255                 2260                 2265             


Gln Tyr  Glu Gln Leu Thr Ala  Ala Gly Gln Gly Ile  Leu Ser Arg 
    2270                 2275                 2280             


Pro Gly  Glu Asp Pro Ser Leu  Arg Gly Ile Val Lys  Glu Gln Leu 
    2285                 2290                 2295             


Ala Ala  Val Thr Gln Lys Trp  Asp Ser Leu Thr Gly  Gln Leu Ser 
    2300                 2305                 2310             


Asp Arg  Cys Asp Trp Ile Asp  Gln Ala Ile Val Lys  Ser Thr Gln 
    2315                 2320                 2325             


Tyr Gln  Ser Leu Leu Arg Ser  Leu Ser Asp Lys Leu  Ser Asp Leu 
    2330                 2335                 2340             


Asp Asn  Lys Leu Ser Ser Ser  Leu Ala Val Ser Thr  His Pro Asp 
    2345                 2350                 2355             


Ala Met  Asn Gln Gln Leu Glu  Thr Ala Gln Lys Met  Lys Gln Glu 
    2360                 2365                 2370             


Ile Gln  Gln Glu Lys Lys Gln  Ile Lys Val Ala Gln  Ala Leu Cys 
    2375                 2380                 2385             


Glu Asp  Leu Ser Ala Leu Val  Lys Glu Glu Tyr Leu  Lys Ala Glu 
    2390                 2395                 2400             


Leu Ser  Arg Gln Leu Glu Gly  Ile Leu Lys Ser Phe  Lys Asp Val 
    2405                 2410                 2415             


Glu Gln  Lys Ala Glu Asn His  Val Gln His Leu Gln  Ser Ala Cys 
    2420                 2425                 2430             


Ala Ser  Ser His Gln Phe Gln  Gln Met Ser Arg Asp  Phe Gln Ala 
    2435                 2440                 2445             


Trp Leu  Asp Thr Lys Lys Glu  Glu Gln Asn Lys Ser  His Pro Ile 
    2450                 2455                 2460             


Ser Ala  Lys Leu Asp Val Leu  Glu Ser Leu Ile Lys  Asp His Lys 
    2465                 2470                 2475             


Asp Phe  Ser Lys Thr Leu Thr  Ala Gln Ser His Met  Tyr Glu Lys 
    2480                 2485                 2490             


Thr Ile  Ala Glu Gly Glu Asn  Leu Leu Leu Lys Thr  Gln Gly Ser 
    2495                 2500                 2505             


Glu Lys  Ala Ala Leu Gln Leu  Gln Leu Asn Thr Ile  Lys Thr Asn 
    2510                 2515                 2520             


Trp Asp  Thr Phe Asn Lys Gln  Val Lys Glu Arg Glu  Asn Lys Leu 
    2525                 2530                 2535             


Lys Glu  Ser Leu Glu Lys Ala  Leu Lys Tyr Lys Glu  Gln Val Glu 
    2540                 2545                 2550             


Thr Leu  Trp Pro Trp Ile Asp  Lys Cys Gln Asn Asn  Leu Glu Glu 
    2555                 2560                 2565             


Ile Lys  Phe Cys Leu Asp Pro  Ala Glu Gly Glu Asn  Ser Ile Ala 
    2570                 2575                 2580             


Lys Leu  Lys Ser Leu Gln Lys  Glu Met Asp Gln His  Phe Gly Met 
    2585                 2590                 2595             


Val Glu  Leu Leu Asn Asn Thr  Ala Asn Ser Leu Leu  Ser Val Cys 
    2600                 2605                 2610             


Glu Ile  Asp Lys Glu Val Val  Thr Asp Glu Asn Lys  Ser Leu Ile 
    2615                 2620                 2625             


Gln Lys  Val Asp Met Val Thr  Glu Gln Leu His Ser  Lys Lys Phe 
    2630                 2635                 2640             


Cys Leu  Glu Asn Met Thr Gln  Lys Phe Lys Glu Phe  Gln Glu Val 
    2645                 2650                 2655             


Ser Lys  Glu Ser Lys Arg Gln  Leu Gln Cys Ala Lys  Glu Gln Leu 
    2660                 2665                 2670             


Asp Ile  His Asp Ser Leu Gly  Ser Gln Ala Tyr Ser  Asn Lys Tyr 
    2675                 2680                 2685             


Leu Thr  Met Leu Gln Thr Gln  Gln Lys Ser Leu Gln  Ala Leu Lys 
    2690                 2695                 2700             


His Gln  Val Asp Leu Ala Lys  Arg Leu Ala Gln Asp  Leu Val Val 
    2705                 2710                 2715             


Glu Ala  Ser Asp Ser Lys Gly  Thr Ser Asp Val Leu  Leu Gln Val 
    2720                 2725                 2730             


Glu Thr  Ile Ala Gln Glu His  Ser Thr Leu Ser Gln  Gln Val Asp 
    2735                 2740                 2745             


Glu Lys  Cys Ser Phe Leu Glu  Thr Lys Leu Gln Gly  Ile Gly His 
    2750                 2755                 2760             


Phe Gln  Asn Thr Ile Arg Glu  Met Phe Ser Gln Phe  Ala Glu Phe 
    2765                 2770                 2775             


Asp Asp  Glu Leu Asp Ser Met  Ala Pro Val Gly Arg  Asp Ala Glu 
    2780                 2785                 2790             


Thr Leu  Gln Lys Gln Lys Glu  Thr Ile Lys Ala Phe  Leu Lys Lys 
    2795                 2800                 2805             


Leu Glu  Ala Leu Met Ala Ser  Asn Asp Asn Ala Asn  Lys Thr Cys 
    2810                 2815                 2820             


Lys Met  Met Leu Ala Thr Glu  Glu Thr Ser Pro Asp  Leu Val Gly 
    2825                 2830                 2835             


Ile Lys  Arg Asp Leu Glu Ala  Leu Ser Lys Gln Cys  Asn Lys Leu 
    2840                 2845                 2850             


Leu Asp  Arg Ala Gln Ala Arg  Glu Glu Gln Val Glu  Gly Thr Ile 
    2855                 2860                 2865             


Lys Arg  Leu Glu Glu Phe Tyr  Ser Lys Leu Lys Glu  Phe Ser Ile 
    2870                 2875                 2880             


Leu Leu  Gln Lys Ala Glu Glu  His Glu Glu Ser Gln  Gly Pro Val 
    2885                 2890                 2895             


Gly Met  Glu Thr Glu Thr Ile  Asn Gln Gln Leu Asn  Met Phe Lys 
    2900                 2905                 2910             


Val Phe  Gln Lys Glu Glu Ile  Glu Pro Leu Gln Gly  Lys Gln Gln 
    2915                 2920                 2925             


Asp Val  Asn Trp Leu Gly Gln  Gly Leu Ile Gln Ser  Ala Ala Lys 
    2930                 2935                 2940             


Ser Thr  Ser Thr Gln Gly Leu  Glu His Asp Leu Asp  Asp Val Asn 
    2945                 2950                 2955             


Ala Arg  Trp Lys Thr Leu Asn  Lys Lys Val Ala Gln  Arg Ala Ala 
    2960                 2965                 2970             


Gln Leu  Gln Glu Ala Leu Leu  His Cys Gly Arg Phe  Gln Asp Ala 
    2975                 2980                 2985             


Leu Glu  Ser Leu Leu Ser Trp  Met Val Asp Thr Glu  Glu Leu Val 
    2990                 2995                 3000             


Ala Asn  Gln Lys Pro Pro Ser  Ala Glu Phe Lys Val  Val Lys Ala 
    3005                 3010                 3015             


Gln Ile  Gln Glu Gln Lys Leu  Leu Gln Arg Leu Leu  Asp Asp Arg 
    3020                 3025                 3030             


Lys Ser  Thr Val Glu Val Ile  Lys Arg Glu Gly Glu  Lys Ile Ala 
    3035                 3040                 3045             


Thr Thr  Ala Glu Pro Ala Asp  Lys Val Lys Ile Leu  Lys Gln Leu 
    3050                 3055                 3060             


Ser Leu  Leu Asp Ser Arg Trp  Glu Ala Leu Leu Asn  Lys Ala Glu 
    3065                 3070                 3075             


Thr Arg  Asn Arg Gln Leu Glu  Gly Ile Ser Val Val  Ala Gln Gln 
    3080                 3085                 3090             


Phe His  Glu Thr Leu Glu Pro  Leu Asn Glu Trp Leu  Thr Thr Ile 
    3095                 3100                 3105             


Glu Lys  Arg Leu Val Asn Cys  Glu Pro Ile Gly Thr  Gln Ala Ser 
    3110                 3115                 3120             


Lys Leu  Glu Glu Gln Ile Ala  Gln His Lys Ala Leu  Glu Asp Asp 
    3125                 3130                 3135             


Ile Ile  Asn His Asn Lys His  Leu His Gln Ala Val  Ser Ile Gly 
    3140                 3145                 3150             


Gln Ser  Leu Lys Val Leu Ser  Ser Arg Glu Asp Lys  Asp Met Val 
    3155                 3160                 3165             


Gln Ser  Lys Leu Asp Phe Ser  Gln Val Trp Tyr Ile  Glu Ile Gln 
    3170                 3175                 3180             


Glu Lys  Ser His Ser Arg Ser  Glu Leu Leu Gln Gln  Ala Leu Cys 
    3185                 3190                 3195             


Asn Ala  Lys Ile Phe Gly Glu  Asp Glu Val Glu Leu  Met Asn Trp 
    3200                 3205                 3210             


Leu Asn  Glu Val His Asp Lys  Leu Ser Lys Leu Ser  Val Gln Asp 
    3215                 3220                 3225             


Tyr Ser  Thr Glu Gly Leu Trp  Lys Gln Gln Ser Glu  Leu Arg Val 
    3230                 3235                 3240             


Leu Gln  Glu Asp Ile Leu Leu  Arg Lys Gln Asn Val  Asp Gln Ala 
    3245                 3250                 3255             


Leu Leu  Asn Gly Leu Glu Leu  Leu Lys Gln Thr Thr  Gly Asp Glu 
    3260                 3265                 3270             


Val Leu  Ile Ile Gln Asp Lys  Leu Glu Ala Ile Lys  Ala Arg Tyr 
    3275                 3280                 3285             


Lys Asp  Ile Thr Lys Leu Ser  Thr Asp Val Ala Lys  Thr Leu Glu 
    3290                 3295                 3300             


Gln Ala  Leu Gln Leu Ala Arg  Arg Leu His Ser Thr  His Glu Glu 
    3305                 3310                 3315             


Leu Cys  Thr Trp Leu Asp Lys  Val Glu Val Glu Leu  Leu Ser Tyr 
    3320                 3325                 3330             


Glu Thr  Gln Val Leu Lys Gly  Glu Glu Ala Ser Gln  Ala Gln Met 
    3335                 3340                 3345             


Arg Pro  Lys Glu Leu Lys Lys  Glu Ala Lys Asn Asn  Lys Ala Leu 
    3350                 3355                 3360             


Leu Asp  Ser Leu Asn Glu Val  Ser Ser Ala Leu Leu  Glu Leu Val 
    3365                 3370                 3375             


Pro Trp  Arg Ala Arg Glu Gly  Leu Glu Lys Met Val  Ala Glu Asp 
    3380                 3385                 3390             


Asn Glu  Arg Tyr Arg Leu Val  Ser Asp Thr Ile Thr  Gln Lys Val 
    3395                 3400                 3405             


Glu Glu  Ile Asp Ala Ala Ile  Leu Arg Ser Gln Gln  Phe Asp Gln 
    3410                 3415                 3420             


Ala Ala  Asp Ala Glu Leu Ser  Trp Ile Thr Glu Thr  Glu Lys Lys 
    3425                 3430                 3435             


Leu Met  Ser Leu Gly Asp Ile  Arg Leu Glu Gln Asp  Gln Thr Ser 
    3440                 3445                 3450             


Ala Gln  Leu Gln Val Gln Lys  Thr Phe Thr Met Glu  Ile Leu Arg 
    3455                 3460                 3465             


His Lys  Asp Ile Ile Asp Asp  Leu Val Lys Ser Gly  His Lys Ile 
    3470                 3475                 3480             


Met Thr  Ala Cys Ser Glu Glu  Glu Lys Gln Ser Met  Lys Lys Lys 
    3485                 3490                 3495             


Leu Asp  Lys Val Leu Lys Asn  Tyr Asp Thr Ile Cys  Gln Ile Asn 
    3500                 3505                 3510             


Ser Glu  Arg Tyr Leu Gln Leu  Glu Arg Ala Gln Ser  Leu Val Asn 
    3515                 3520                 3525             


Gln Phe  Trp Glu Thr Tyr Glu  Glu Leu Trp Pro Trp  Leu Thr Glu 
    3530                 3535                 3540             


Thr Gln  Ser Ile Ile Ser Gln  Leu Pro Ala Pro Ala  Leu Glu Tyr 
    3545                 3550                 3555             


Glu Thr  Leu Arg Gln Gln Gln  Glu Glu His Arg Gln  Leu Arg Glu 
    3560                 3565                 3570             


Leu Ile  Ala Glu His Lys Pro  His Ile Asp Lys Met  Asn Lys Thr 
    3575                 3580                 3585             


Gly Pro  Gln Leu Leu Glu Leu  Ser Pro Gly Glu Gly  Phe Ser Ile 
    3590                 3595                 3600             


Gln Glu  Lys Tyr Val Ala Ala  Asp Thr Leu Tyr Ser  Gln Ile Lys 
    3605                 3610                 3615             


Glu Asp  Val Lys Lys Arg Ala  Val Ala Leu Asp Glu  Ala Ile Ser 
    3620                 3625                 3630             


Gln Ser  Thr Gln Phe His Asp  Lys Ile Asp Gln Ile  Leu Glu Ser 
    3635                 3640                 3645             


Leu Glu  Arg Ile Val Glu Arg  Leu Arg Gln Pro Pro  Ser Ile Ser 
    3650                 3655                 3660             


Ala Glu  Val Glu Lys Ile Lys  Glu Gln Ile Ser Glu  Asn Lys Asn 
    3665                 3670                 3675             


Val Ser  Val Asp Met Glu Lys  Leu Gln Pro Leu Tyr  Glu Thr Leu 
    3680                 3685                 3690             


Lys Gln  Arg Gly Glu Glu Met  Ile Ala Arg Ser Gly  Gly Thr Asp 
    3695                 3700                 3705             


Lys Asp  Ile Ser Ala Lys Ala  Val Gln Asp Lys Leu  Asp Gln Met 
    3710                 3715                 3720             


Val Phe  Ile Trp Glu Asn Ile  His Thr Leu Val Glu  Glu Arg Glu 
    3725                 3730                 3735             


Ala Lys  Leu Leu Asp Val Met  Glu Leu Ala Glu Lys  Phe Trp Cys 
    3740                 3745                 3750             


Asp His  Met Ser Leu Ile Val  Thr Ile Lys Asp Thr  Gln Asp Phe 
    3755                 3760                 3765             


Ile Arg  Asp Leu Glu Asp Pro  Gly Ile Asp Pro Ser  Val Val Lys 
    3770                 3775                 3780             


Gln Gln  Gln Glu Ala Ala Glu  Thr Ile Arg Glu Glu  Ile Asp Gly 
    3785                 3790                 3795             


Leu Gln  Glu Glu Leu Asp Ile  Val Ile Asn Leu Gly  Ser Glu Leu 
    3800                 3805                 3810             


Ile Ala  Ala Cys Gly Glu Pro  Asp Lys Pro Ile Val  Lys Lys Ser 
    3815                 3820                 3825             


Ile Asp  Glu Leu Asn Ser Ala  Trp Asp Ser Leu Asn  Lys Ala Trp 
    3830                 3835                 3840             


Lys Asp  Arg Ile Asp Lys Leu  Glu Glu Ala Met Gln  Ala Ala Val 
    3845                 3850                 3855             


Gln Tyr  Gln Asp Gly Leu Gln  Ala Val Phe Asp Trp  Val Asp Ile 
    3860                 3865                 3870             


Ala Gly  Gly Lys Leu Ala Ser  Met Ser Pro Ile Gly  Thr Asp Leu 
    3875                 3880                 3885             


Glu Thr  Val Lys Gln Gln Ile  Glu Glu Leu Lys Gln  Phe Lys Ser 
    3890                 3895                 3900             


Glu Ala  Tyr Gln Gln Gln Ile  Glu Met Glu Arg Leu  Asn His Gln 
    3905                 3910                 3915             


Ala Glu  Leu Leu Leu Lys Lys  Val Thr Glu Glu Ser  Asp Lys His 
    3920                 3925                 3930             


Thr Val  Gln Asp Pro Leu Met  Glu Leu Lys Leu Ile  Trp Asp Ser 
    3935                 3940                 3945             


Leu Glu  Glu Arg Ile Ile Asn  Arg Gln His Lys Leu  Glu Gly Ala 
    3950                 3955                 3960             


Leu Leu  Ala Leu Gly Gln Phe  Gln His Ala Leu Asp  Glu Leu Leu 
    3965                 3970                 3975             


Ala Trp  Leu Thr His Thr Glu  Gly Leu Leu Ser Glu  Gln Lys Pro 
    3980                 3985                 3990             


Val Gly  Gly Asp Pro Lys Ala  Ile Glu Ile Glu Leu  Ala Lys His 
    3995                 4000                 4005             


His Val  Leu Gln Asn Asp Val  Leu Ala His Gln Ser  Thr Val Glu 
    4010                 4015                 4020             


Ala Val  Asn Lys Ala Gly Asn  Asp Leu Ile Glu Ser  Ser Ala Gly 
    4025                 4030                 4035             


Glu Glu  Ala Ser Asn Leu Gln  Asn Lys Leu Glu Val  Leu Asn Gln 
    4040                 4045                 4050             


Arg Trp  Gln Asn Val Leu Glu  Lys Thr Glu Gln Arg  Lys Gln Gln 
    4055                 4060                 4065             


Leu Asp  Gly Ala Leu Arg Gln  Ala Lys Gly Phe His  Gly Glu Ile 
    4070                 4075                 4080             


Glu Asp  Leu Gln Gln Trp Leu  Thr Asp Thr Glu Arg  His Leu Leu 
    4085                 4090                 4095             


Ala Ser  Lys Pro Leu Gly Gly  Leu Pro Glu Thr Ala  Lys Glu Gln 
    4100                 4105                 4110             


Leu Asn  Val His Met Glu Val  Cys Ala Ala Phe Glu  Ala Lys Glu 
    4115                 4120                 4125             


Glu Thr  Tyr Lys Ser Leu Met  Gln Lys Gly Gln Gln  Met Leu Ala 
    4130                 4135                 4140             


Arg Cys  Pro Lys Ser Ala Glu  Thr Asn Ile Asp Gln  Asp Ile Asn 
    4145                 4150                 4155             


Asn Leu  Lys Glu Lys Trp Glu  Ser Val Glu Thr Lys  Leu Asn Glu 
    4160                 4165                 4170             


Arg Lys  Thr Lys Leu Glu Glu  Ala Leu Asn Leu Ala  Met Glu Phe 
    4175                 4180                 4185             


His Asn  Ser Leu Gln Asp Phe  Ile Asn Trp Leu Thr  Gln Ala Glu 
    4190                 4195                 4200             


Gln Thr  Leu Asn Val Ala Ser  Arg Pro Ser Leu Ile  Leu Asp Thr 
    4205                 4210                 4215             


Val Leu  Phe Gln Ile Asp Glu  His Lys Val Phe Ala  Asn Glu Val 
    4220                 4225                 4230             


Asn Ser  His Arg Glu Gln Ile  Ile Glu Leu Asp Lys  Thr Gly Thr 
    4235                 4240                 4245             


His Leu  Lys Tyr Phe Ser Gln  Lys Gln Asp Val Val  Leu Ile Lys 
    4250                 4255                 4260             


Asn Leu  Leu Ile Ser Val Gln  Ser Arg Trp Glu Lys  Val Val Gln 
    4265                 4270                 4275             


Arg Leu  Val Glu Arg Gly Arg  Ser Leu Asp Asp Ala  Arg Lys Arg 
    4280                 4285                 4290             


Ala Lys  Gln Phe His Glu Ala  Trp Ser Lys Leu Met  Glu Trp Leu 
    4295                 4300                 4305             


Glu Glu  Ser Glu Lys Ser Leu  Asp Ser Glu Leu Glu  Ile Ala Asn 
    4310                 4315                 4320             


Asp Pro  Asp Lys Ile Lys Thr  Gln Leu Ala Gln His  Lys Glu Phe 
    4325                 4330                 4335             


Gln Lys  Ser Leu Gly Ala Lys  His Ser Val Tyr Asp  Thr Thr Asn 
    4340                 4345                 4350             


Arg Thr  Gly Arg Ser Leu Lys  Glu Lys Thr Ser Leu  Ala Asp Asp 
    4355                 4360                 4365             


Asn Leu  Lys Leu Asp Asp Met  Leu Ser Glu Leu Arg  Asp Lys Trp 
    4370                 4375                 4380             


Asp Thr  Ile Cys Gly Lys Ser  Val Glu Arg Gln Asn  Lys Leu Glu 
    4385                 4390                 4395             


Glu Ala  Leu Leu Phe Ser Gly  Gln Phe Thr Asp Ala  Leu Gln Ala 
    4400                 4405                 4410             


Leu Ile  Asp Trp Leu Tyr Arg  Val Glu Pro Gln Leu  Ala Glu Asp 
    4415                 4420                 4425             


Gln Pro  Val His Gly Asp Ile  Asp Leu Val Met Asn  Leu Ile Asp 
    4430                 4435                 4440             


Asn His  Lys Ala Phe Gln Lys  Glu Leu Gly Lys Arg  Thr Ser Ser 
    4445                 4450                 4455             


Val Gln  Ala Leu Lys Arg Ser  Ala Arg Glu Leu Ile  Glu Gly Ser 
    4460                 4465                 4470             


Arg Asp  Asp Ser Ser Trp Val  Lys Val Gln Met Gln  Glu Leu Ser 
    4475                 4480                 4485             


Thr Arg  Trp Glu Thr Val Cys  Ala Leu Ser Ile Ser  Lys Gln Thr 
    4490                 4495                 4500             


Arg Leu  Glu Ala Ala Leu Arg  Gln Ala Glu Glu Phe  His Ser Val 
    4505                 4510                 4515             


Val His  Ala Leu Leu Glu Trp  Leu Ala Glu Ala Glu  Gln Thr Leu 
    4520                 4525                 4530             


Arg Phe  His Gly Val Leu Pro  Asp Asp Glu Asp Ala  Leu Arg Thr 
    4535                 4540                 4545             


Leu Ile  Asp Gln His Lys Glu  Phe Met Lys Lys Leu  Glu Glu Lys 
    4550                 4555                 4560             


Arg Ala  Glu Leu Asn Lys Ala  Thr Thr Met Gly Asp  Thr Val Leu 
    4565                 4570                 4575             


Ala Ile  Cys His Pro Asp Ser  Ile Thr Thr Ile Lys  His Trp Ile 
    4580                 4585                 4590             


Thr Ile  Ile Arg Ala Arg Phe  Glu Glu Val Leu Ala  Trp Ala Lys 
    4595                 4600                 4605             


Gln His  Gln Gln Arg Leu Ala  Ser Ala Leu Ala Gly  Leu Ile Ala 
    4610                 4615                 4620             


Lys Gln  Glu Leu Leu Glu Ala  Leu Leu Ala Trp Leu  Gln Trp Ala 
    4625                 4630                 4635             


Glu Thr  Thr Leu Thr Asp Lys  Asp Lys Glu Val Ile  Pro Gln Glu 
    4640                 4645                 4650             


Ile Glu  Glu Val Lys Ala Leu  Ile Ala Glu His Gln  Thr Phe Met 
    4655                 4660                 4665             


Glu Glu  Met Thr Arg Lys Gln  Pro Asp Val Asp Lys  Val Thr Lys 
    4670                 4675                 4680             


Thr Tyr  Lys Arg Arg Ala Ala  Asp Pro Ser Ser Leu  Gln Ser His 
    4685                 4690                 4695             


Ile Pro  Val Leu Asp Lys Gly  Arg Ala Gly Arg Lys  Arg Phe Pro 
    4700                 4705                 4710             


Ala Ser  Ser Leu Tyr Pro Ser  Gly Ser Gln Thr Gln  Ile Glu Thr 
    4715                 4720                 4725             


Lys Asn  Pro Arg Val Asn Leu  Leu Val Ser Lys Trp  Gln Gln Val 
    4730                 4735                 4740             


Trp Leu  Leu Ala Leu Glu Arg  Arg Arg Lys Leu Asn  Asp Ala Leu 
    4745                 4750                 4755             


Asp Arg  Leu Glu Glu Leu Arg  Glu Phe Ala Asn Phe  Asp Phe Asp 
    4760                 4765                 4770             


Ile Trp  Arg Lys Lys Tyr Met  Arg Trp Met Asn His  Lys Lys Ser 
    4775                 4780                 4785             


Arg Val  Met Asp Phe Phe Arg  Arg Ile Asp Lys Asp  Gln Asp Gly 
    4790                 4795                 4800             


Lys Ile  Thr Arg Gln Glu Phe  Ile Asp Gly Ile Leu  Ser Ser Lys 
    4805                 4810                 4815             


Phe Pro  Thr Ser Arg Leu Glu  Met Ser Ala Val Ala  Asp Ile Phe 
    4820                 4825                 4830             


Asp Arg  Asp Gly Asp Gly Tyr  Ile Asp Tyr Tyr Glu  Phe Val Ala 
    4835                 4840                 4845             


Ala Leu  His Pro Asn Lys Asp  Ala Tyr Lys Pro Ile  Thr Asp Ala 
    4850                 4855                 4860             


Asp Lys  Ile Glu Asp Glu Val  Thr Arg Gln Val Ala  Lys Cys Lys 
    4865                 4870                 4875             


Cys Ala  Lys Arg Phe Gln Val  Glu Gln Ile Gly Asp  Asn Lys Tyr 
    4880                 4885                 4890             


Arg Phe  Phe Leu Gly Asn Gln  Phe Gly Asp Ser Gln  Gln Leu Arg 
    4895                 4900                 4905             


Leu Val  Arg Ile Leu Arg Ser  Thr Val Met Val Arg  Val Gly Gly 
    4910                 4915                 4920             


Gly Trp  Met Ala Leu Asp Glu  Phe Leu Val Lys Asn  Asp Pro Cys 
    4925                 4930                 4935             


Arg Ala  Lys Gly Arg Thr Asn  Met Glu Leu Arg Glu  Lys Phe Ile 
    4940                 4945                 4950             


Leu Ala  Asp Gly Ala Ser Gln  Gly Met Ala Ala Phe  Arg Pro Arg 
    4955                 4960                 4965             


Gly Arg  Arg Ser Arg Pro Ser  Ser Arg Gly Ala Ser  Pro Asn Arg 
    4970                 4975                 4980             


Ser Thr  Ser Val Ser Ser Gln  Ala Ala Gln Ala Ala  Ser Pro Gln 
    4985                 4990                 4995             


Val Pro  Ala Thr Thr Thr Pro  Lys Ile Leu His Pro  Leu Thr Arg 
    5000                 5005                 5010             


Asn Tyr  Gly Lys Pro Trp Leu  Thr Asn Ser Lys Met  Ser Thr Pro 
    5015                 5020                 5025             


Cys Lys  Ala Ala Glu Cys Ser  Asp Phe Pro Val Pro  Ser Ala Glu 
    5030                 5035                 5040             


Gly Thr  Pro Ile Gln Gly Ser  Lys Leu Arg Leu Pro  Gly Tyr Leu 
    5045                 5050                 5055             


Ser Gly  Lys Gly Phe His Ser  Gly Glu Asp Ser Gly  Leu Ile Thr 
    5060                 5065                 5070             


Thr Ala  Ala Ala Arg Val Arg  Thr Gln Phe Ala Asp  Ser Lys Lys 
    5075                 5080                 5085             


Thr Pro  Ser Arg Pro Gly Ser  Arg Ala Gly Ser Lys  Ala Gly Ser 
    5090                 5095                 5100             


Arg Ala  Ser Ser Arg Arg Gly  Ser Asp Ala Ser Asp  Phe Asp Ile 
    5105                 5110                 5115             


Ser Glu  Ile Gln Ser Val Cys  Ser Asp Val Glu Thr  Val Pro Gln 
    5120                 5125                 5130             


Thr His  Arg Pro Thr Pro Arg  Ala Gly Ser Arg Pro  Ser Thr Ala 
    5135                 5140                 5145             


Lys Pro  Ser Lys Ile Pro Thr  Pro Gln Arg Lys Ser  Pro Ala Ser 
    5150                 5155                 5160             


Lys Leu  Asp Lys Ser Ser Lys  Arg 
    5165                 5170     


<210>  4100
<211>  629
<212>  PRT
<213>  Homo sapiens

<400>  4100

Met Thr Ala Glu Gly Pro Ser Pro Pro Ala Arg Trp His Arg Arg Leu 
1               5                   10                  15      


Pro Gly Leu Trp Ala Ala Ala Leu Leu Leu Leu Gly Leu Pro Arg Leu 
            20                  25                  30          


Ser Val Arg Ala Asp Gly Lys Phe Phe Val Leu Glu Ser Gln Asn Gly 
        35                  40                  45              


Ser Gln Gly Leu Gln Leu Glu Ala Ala Arg Leu Ser Cys Lys Ser Arg 
    50                  55                  60                  


Gly Ala His Leu Ala Ser Ala Asp Glu Leu Arg Arg Val Val Gln Asp 
65                  70                  75                  80  


Cys Ser Phe Ala Val Cys Thr Thr Gly Trp Leu Ala Asp Gly Thr Leu 
                85                  90                  95      


Gly Thr Thr Val Cys Ser Lys Gly Ser Gly Glu Gln Gln Ile Met Arg 
            100                 105                 110         


Ala Val Asp Val Arg Ile Glu Ser Asn Pro Val Pro Gly Gly Thr Tyr 
        115                 120                 125             


Ser Ala Leu Cys Ile Lys Asp Glu Glu Lys Pro Cys Gly Asp Pro Pro 
    130                 135                 140                 


Ser Phe Pro His Thr Ile Leu Gln Gly Arg Thr Gly Leu Glu Met Gly 
145                 150                 155                 160 


Asp Glu Leu Leu Tyr Val Cys Ala Pro Gly His Ile Met Gly His Arg 
                165                 170                 175     


Glu Thr Ala Phe Thr Leu Leu Cys Asn Ser Cys Gly Glu Trp Tyr Gly 
            180                 185                 190         


Leu Val Gln Ala Cys Gly Lys Asp Glu Ala Glu Ala His Ile Asp Tyr 
        195                 200                 205             


Glu Asp Asn Phe Pro Asp Asp Arg Ser Val Ser Phe Arg Glu Leu Met 
    210                 215                 220                 


Glu Asp Ser Arg Thr Glu Ala Asp Glu Asp Arg Gly Gln Gly Asp Ser 
225                 230                 235                 240 


Ser Glu Glu Ala Pro Lys Gln Asp Arg Leu Val Ser Ile Ser Val Gly 
                245                 250                 255     


Arg Glu Asn Ile Ala Arg Asp Lys Val Phe Val Pro Thr Thr Gly Leu 
            260                 265                 270         


Pro Gly Ala Gly Ser Ser Val Pro Ala Asp Ser Pro Gly Ser Arg Leu 
        275                 280                 285             


Leu Gln Lys His Leu Phe Trp Phe Pro Ala Glu Ala Phe His Lys Pro 
    290                 295                 300                 


Gly Leu Glu Lys Glu Val Asp Asp Asp Thr Lys Lys Gln Phe Ser Ala 
305                 310                 315                 320 


Gly Asp Asn His Ser Gly Val Lys Leu Val Pro Gly Glu Pro Glu Thr 
                325                 330                 335     


Lys Val Ile Tyr Gly Asn Thr Asp Gly Pro Ser Gly Pro Phe Val Gly 
            340                 345                 350         


Lys Asn Asp Ser Lys Ala Gly Asp Pro Val Val Ser Ser Ser Asp Glu 
        355                 360                 365             


Ser Trp Leu Asp Gly Tyr Pro Val Thr Glu Gly Ala Trp Arg Lys Thr 
    370                 375                 380                 


Glu Ala Glu Glu Glu Glu Asp Gly Asp Arg Gly Asp Gly Ser Val Gly 
385                 390                 395                 400 


Leu Asp Glu Asn Val Leu Val Thr Pro Asp Gln Pro Ile Leu Val Glu 
                405                 410                 415     


Val Lys Lys Pro Lys Ser Ser Thr Leu Thr Pro Ser Glu Gly Met Thr 
            420                 425                 430         


His Ser Ser Val Leu Pro Ser Gln Met Leu Asp Val Glu Ala Leu Ala 
        435                 440                 445             


Leu Arg Pro Val Asn Ala Ser Glu Thr Glu Gly Ile Gly Asp Gly Asp 
    450                 455                 460                 


Leu Thr Lys Tyr Gln Ser Thr Leu Pro Trp Arg Phe Ile Thr Glu Glu 
465                 470                 475                 480 


Ser Pro Met Ala Thr Leu Ser Tyr Glu Leu Thr Ser Ser Thr Leu Glu 
                485                 490                 495     


Ile Leu Thr Val Asn Thr Val Lys Gln Thr Pro Asn His Ile Pro Ser 
            500                 505                 510         


Thr Ile Met Ala Thr Thr Gln Pro Pro Val Glu Thr Thr Val Pro Glu 
        515                 520                 525             


Ile Gln Asp Ser Phe Pro Tyr Leu Leu Ser Glu Asp Phe Phe Gly Gln 
    530                 535                 540                 


Glu Gly Pro Gly Pro Gly Ala Ser Glu Glu Leu His Pro Thr Leu Glu 
545                 550                 555                 560 


Ser Cys Val Gly Asp Gly Cys Pro Gly Leu Ser Arg Gly Pro Val Ile 
                565                 570                 575     


Ala Thr Ile Val Thr Val Leu Cys Leu Leu Leu Leu Leu Ala Gly Val 
            580                 585                 590         


Gly Met Val Trp Gly Tyr Arg Lys Cys Gln His Lys Ser Ser Val Tyr 
        595                 600                 605             


Lys Leu Asn Val Gly Gln Arg Gln Ala Arg His Tyr His Gln Gln Ile 
    610                 615                 620                 


Glu Met Glu Lys Val 
625                 


<210>  4101
<211>  617
<212>  PRT
<213>  Homo sapiens

<400>  4101

Met Arg Cys Leu Ala Ala Arg Val Asn Tyr Lys Thr Leu Ile Ile Ile 
1               5                   10                  15      


Cys Ala Leu Phe Thr Leu Val Thr Val Leu Leu Trp Asn Lys Cys Ser 
            20                  25                  30          


Ser Asp Lys Ala Ile Gln Phe Pro Arg Arg Ser Ser Ser Gly Phe Arg 
        35                  40                  45              


Val Asp Gly Phe Glu Lys Arg Ala Ala Ala Ser Glu Ser Asn Asn Tyr 
    50                  55                  60                  


Met Asn His Val Ala Lys Gln Gln Ser Glu Glu Ala Phe Pro Gln Glu 
65                  70                  75                  80  


Gln Gln Lys Ala Pro Pro Val Val Gly Gly Phe Asn Ser Asn Val Gly 
                85                  90                  95      


Ser Lys Val Leu Gly Leu Lys Tyr Glu Glu Ile Asp Cys Leu Ile Asn 
            100                 105                 110         


Asp Glu His Thr Ile Lys Gly Arg Arg Glu Gly Asn Glu Val Phe Leu 
        115                 120                 125             


Pro Phe Thr Trp Val Glu Lys Tyr Phe Asp Val Tyr Gly Lys Val Val 
    130                 135                 140                 


Gln Tyr Asp Gly Tyr Asp Arg Phe Glu Phe Ser His Ser Tyr Ser Lys 
145                 150                 155                 160 


Val Tyr Ala Gln Arg Ala Pro Tyr His Pro Asp Gly Val Phe Met Ser 
                165                 170                 175     


Phe Glu Gly Tyr Asn Val Glu Val Arg Asp Arg Val Lys Cys Ile Ser 
            180                 185                 190         


Gly Val Glu Gly Val Pro Leu Ser Thr Gln Trp Gly Pro Gln Gly Tyr 
        195                 200                 205             


Phe Tyr Pro Ile Gln Ile Ala Gln Tyr Gly Leu Ser His Tyr Ser Lys 
    210                 215                 220                 


Asn Leu Thr Glu Lys Pro Pro His Ile Glu Val Tyr Glu Thr Ala Glu 
225                 230                 235                 240 


Asp Arg Asp Lys Asn Lys Pro Asn Asp Trp Thr Val Pro Lys Gly Cys 
                245                 250                 255     


Phe Met Ala Asn Val Ala Asp Lys Ser Arg Phe Thr Asn Val Lys Gln 
            260                 265                 270         


Phe Ile Ala Pro Glu Thr Ser Glu Gly Val Ser Leu Gln Leu Gly Asn 
        275                 280                 285             


Thr Lys Asp Phe Ile Ile Ser Phe Asp Leu Lys Phe Leu Thr Asn Gly 
    290                 295                 300                 


Ser Val Ser Val Val Leu Glu Thr Thr Glu Lys Asn Gln Leu Phe Thr 
305                 310                 315                 320 


Ile His Tyr Val Ser Asn Ala Gln Leu Ile Ala Phe Lys Glu Arg Asp 
                325                 330                 335     


Ile Tyr Tyr Gly Ile Gly Pro Arg Thr Ser Trp Ser Thr Val Thr Arg 
            340                 345                 350         


Asp Leu Val Thr Asp Leu Arg Lys Gly Val Gly Leu Ser Asn Thr Lys 
        355                 360                 365             


Ala Val Lys Pro Thr Lys Ile Met Pro Lys Lys Val Val Arg Leu Ile 
    370                 375                 380                 


Ala Lys Gly Lys Gly Phe Leu Asp Asn Ile Thr Ile Ser Thr Thr Ala 
385                 390                 395                 400 


His Met Ala Ala Phe Phe Ala Ala Ser Asp Trp Leu Val Arg Asn Gln 
                405                 410                 415     


Asp Glu Lys Gly Gly Trp Pro Ile Met Val Thr Arg Lys Leu Gly Glu 
            420                 425                 430         


Gly Phe Lys Ser Leu Glu Pro Gly Trp Tyr Ser Ala Met Ala Gln Gly 
        435                 440                 445             


Gln Ala Ile Ser Thr Leu Val Arg Ala Tyr Leu Leu Thr Lys Asp His 
    450                 455                 460                 


Ile Phe Leu Asn Ser Ala Leu Arg Ala Thr Ala Pro Tyr Lys Phe Leu 
465                 470                 475                 480 


Ser Glu Gln His Gly Val Lys Ala Val Phe Met Asn Lys His Asp Trp 
                485                 490                 495     


Tyr Glu Glu Tyr Pro Thr Thr Pro Ser Ser Phe Val Leu Asn Gly Phe 
            500                 505                 510         


Met Tyr Ser Leu Ile Gly Leu Tyr Asp Leu Lys Glu Thr Ala Gly Glu 
        515                 520                 525             


Lys Leu Gly Lys Glu Ala Arg Ser Leu Tyr Glu Arg Gly Met Glu Ser 
    530                 535                 540                 


Leu Lys Ala Met Leu Pro Leu Tyr Asp Thr Gly Ser Gly Thr Ile Tyr 
545                 550                 555                 560 


Asp Leu Arg His Phe Met Leu Gly Ile Ala Pro Asn Leu Ala Arg Trp 
                565                 570                 575     


Asp Tyr His Thr Thr His Ile Asn Gln Leu Gln Leu Leu Ser Thr Ile 
            580                 585                 590         


Asp Glu Ser Pro Val Phe Lys Glu Phe Val Lys Arg Trp Lys Ser Tyr 
        595                 600                 605             


Leu Lys Gly Ser Arg Ala Lys His Asn 
    610                 615         


<210>  4102
<211>  516
<212>  PRT
<213>  Homo sapiens

<400>  4102

Met Gly Leu His Phe Lys Trp Pro Leu Gly Ala Pro Met Leu Ala Ala 
1               5                   10                  15      


Ile Tyr Ala Met Ser Met Val Leu Lys Met Leu Pro Ala Leu Gly Met 
            20                  25                  30          


Ala Cys Pro Pro Lys Cys Arg Cys Glu Lys Leu Leu Phe Tyr Cys Asp 
        35                  40                  45              


Ser Gln Gly Phe His Ser Val Pro Asn Ala Thr Asp Lys Gly Ser Leu 
    50                  55                  60                  


Gly Leu Ser Leu Arg His Asn His Ile Thr Glu Leu Glu Arg Asp Gln 
65                  70                  75                  80  


Phe Ala Ser Phe Ser Gln Leu Thr Trp Leu His Leu Asp His Asn Gln 
                85                  90                  95      


Ile Ser Thr Val Lys Glu Asp Ala Phe Gln Gly Leu Tyr Lys Leu Lys 
            100                 105                 110         


Glu Leu Ile Leu Ser Ser Asn Lys Ile Phe Tyr Leu Pro Asn Thr Thr 
        115                 120                 125             


Phe Thr Gln Leu Ile Asn Leu Gln Asn Leu Asp Leu Ser Phe Asn Gln 
    130                 135                 140                 


Leu Ser Ser Leu His Pro Glu Leu Phe Tyr Gly Leu Arg Lys Leu Gln 
145                 150                 155                 160 


Thr Leu His Leu Arg Ser Asn Ser Leu Arg Thr Ile Pro Val Arg Leu 
                165                 170                 175     


Phe Trp Asp Cys Arg Ser Leu Glu Phe Leu Asp Leu Ser Thr Asn Arg 
            180                 185                 190         


Leu Arg Ser Leu Ala Arg Asn Gly Phe Ala Gly Leu Ile Lys Leu Arg 
        195                 200                 205             


Glu Leu His Leu Glu His Asn Gln Leu Thr Lys Ile Asn Phe Ala His 
    210                 215                 220                 


Phe Leu Arg Leu Ser Ser Leu His Thr Leu Phe Leu Gln Trp Asn Lys 
225                 230                 235                 240 


Ile Ser Asn Leu Thr Cys Gly Met Glu Trp Thr Trp Gly Thr Leu Glu 
                245                 250                 255     


Lys Leu Asp Leu Thr Gly Asn Glu Ile Lys Ala Ile Asp Leu Thr Val 
            260                 265                 270         


Phe Glu Thr Met Pro Asn Leu Lys Ile Leu Leu Met Asp Asn Asn Lys 
        275                 280                 285             


Leu Asn Ser Leu Asp Ser Lys Ile Leu Asn Ser Leu Arg Ser Leu Thr 
    290                 295                 300                 


Thr Val Gly Leu Ser Gly Asn Leu Trp Glu Cys Ser Ala Arg Ile Cys 
305                 310                 315                 320 


Ala Leu Ala Ser Trp Leu Gly Ser Phe Gln Gly Arg Trp Glu His Ser 
                325                 330                 335     


Ile Leu Cys His Ser Pro Asp His Thr Gln Gly Glu Asp Ile Leu Asp 
            340                 345                 350         


Ala Val His Gly Phe Gln Leu Cys Trp Asn Leu Ser Thr Thr Val Thr 
        355                 360                 365             


Val Met Ala Thr Thr Tyr Arg Asp Pro Thr Thr Glu Tyr Thr Lys Arg 
    370                 375                 380                 


Ile Ser Ser Ser Ser Tyr His Val Gly Asp Lys Glu Ile Pro Thr Thr 
385                 390                 395                 400 


Ala Gly Ile Ala Val Thr Thr Glu Glu His Phe Pro Glu Pro Asp Asn 
                405                 410                 415     


Ala Ile Phe Thr Gln Arg Val Ile Thr Gly Thr Met Ala Leu Leu Phe 
            420                 425                 430         


Ser Phe Phe Phe Ile Ile Phe Ile Val Phe Ile Ser Arg Lys Cys Cys 
        435                 440                 445             


Pro Pro Thr Leu Arg Arg Ile Arg Gln Cys Ser Met Val Gln Asn His 
    450                 455                 460                 


Arg Gln Leu Arg Ser Gln Thr Arg Leu His Met Ser Asn Met Ser Asp 
465                 470                 475                 480 


Gln Gly Pro Tyr Asn Glu Tyr Glu Pro Thr His Glu Gly Pro Phe Ile 
                485                 490                 495     


Ile Ile Asn Gly Tyr Gly Gln Cys Lys Cys Gln Gln Leu Pro Tyr Lys 
            500                 505                 510         


Glu Cys Glu Val 
        515     


<210>  4103
<211>  958
<212>  PRT
<213>  Homo sapiens

<400>  4103

Met His Thr Cys Cys Pro Pro Val Thr Leu Glu Gln Asp Leu His Arg 
1               5                   10                  15      


Lys Met His Ser Trp Met Leu Gln Thr Leu Ala Phe Ala Val Thr Ser 
            20                  25                  30          


Leu Val Leu Ser Cys Ala Glu Thr Ile Asp Tyr Tyr Gly Glu Ile Cys 
        35                  40                  45              


Asp Asn Ala Cys Pro Cys Glu Glu Lys Asp Gly Ile Leu Thr Val Ser 
    50                  55                  60                  


Cys Glu Asn Arg Gly Ile Ile Ser Leu Ser Glu Ile Ser Pro Pro Arg 
65                  70                  75                  80  


Phe Pro Ile Tyr His Leu Leu Leu Ser Gly Asn Leu Leu Asn Arg Leu 
                85                  90                  95      


Tyr Pro Asn Glu Phe Val Asn Tyr Thr Gly Ala Ser Ile Leu His Leu 
            100                 105                 110         


Gly Ser Asn Val Ile Gln Asp Ile Glu Thr Gly Ala Phe His Gly Leu 
        115                 120                 125             


Arg Gly Leu Arg Arg Leu His Leu Asn Asn Asn Lys Leu Glu Leu Leu 
    130                 135                 140                 


Arg Asp Asp Thr Phe Leu Gly Leu Glu Asn Leu Glu Tyr Leu Gln Val 
145                 150                 155                 160 


Asp Tyr Asn Tyr Ile Ser Val Ile Glu Pro Asn Ala Phe Gly Lys Leu 
                165                 170                 175     


His Leu Leu Gln Val Leu Ile Leu Asn Asp Asn Leu Leu Ser Ser Leu 
            180                 185                 190         


Pro Asn Asn Leu Phe Arg Phe Val Pro Leu Thr His Leu Asp Leu Arg 
        195                 200                 205             


Gly Asn Arg Leu Lys Leu Leu Pro Tyr Val Gly Leu Leu Gln His Met 
    210                 215                 220                 


Asp Lys Val Val Glu Leu Gln Leu Glu Glu Asn Pro Trp Asn Cys Ser 
225                 230                 235                 240 


Cys Glu Leu Ile Ser Leu Lys Asp Trp Leu Asp Ser Ile Ser Tyr Ser 
                245                 250                 255     


Ala Leu Val Gly Asp Val Val Cys Glu Thr Pro Phe Arg Leu His Gly 
            260                 265                 270         


Arg Asp Leu Asp Glu Val Ser Lys Gln Glu Leu Cys Pro Arg Arg Leu 
        275                 280                 285             


Ile Ser Asp Tyr Glu Met Arg Pro Gln Thr Pro Leu Ser Thr Thr Gly 
    290                 295                 300                 


Tyr Leu His Thr Thr Pro Ala Ser Val Asn Ser Val Ala Thr Ser Ser 
305                 310                 315                 320 


Ser Ala Val Tyr Lys Pro Pro Leu Lys Pro Pro Lys Gly Thr Arg Gln 
                325                 330                 335     


Pro Asn Lys Pro Arg Val Arg Pro Thr Ser Arg Gln Pro Ser Lys Asp 
            340                 345                 350         


Leu Gly Tyr Ser Asn Tyr Gly Pro Ser Ile Ala Tyr Gln Thr Lys Ser 
        355                 360                 365             


Pro Val Pro Leu Glu Cys Pro Thr Ala Cys Ser Cys Asn Leu Gln Ile 
    370                 375                 380                 


Ser Asp Leu Gly Leu Asn Val Asn Cys Gln Glu Arg Lys Ile Glu Ser 
385                 390                 395                 400 


Ile Ala Glu Leu Gln Pro Lys Pro Tyr Asn Pro Lys Lys Met Tyr Leu 
                405                 410                 415     


Thr Glu Asn Tyr Ile Ala Val Val Arg Arg Thr Asp Phe Leu Glu Ala 
            420                 425                 430         


Thr Gly Leu Asp Leu Leu His Leu Gly Asn Asn Arg Ile Ser Met Ile 
        435                 440                 445             


Gln Asp Arg Ala Phe Gly Asp Leu Thr Asn Leu Arg Arg Leu Tyr Leu 
    450                 455                 460                 


Asn Gly Asn Arg Ile Glu Arg Leu Ser Pro Glu Leu Phe Tyr Gly Leu 
465                 470                 475                 480 


Gln Ser Leu Gln Tyr Leu Phe Leu Gln Tyr Asn Leu Ile Arg Glu Ile 
                485                 490                 495     


Gln Ser Gly Thr Phe Asp Pro Val Pro Asn Leu Gln Leu Leu Phe Leu 
            500                 505                 510         


Asn Asn Asn Leu Leu Gln Ala Met Pro Ser Gly Val Phe Ser Gly Leu 
        515                 520                 525             


Thr Leu Leu Arg Leu Asn Leu Arg Ser Asn His Phe Thr Ser Leu Pro 
    530                 535                 540                 


Val Ser Gly Val Leu Asp Gln Leu Lys Ser Leu Ile Gln Ile Asp Leu 
545                 550                 555                 560 


His Asp Asn Pro Trp Asp Cys Thr Cys Asp Ile Val Gly Met Lys Leu 
                565                 570                 575     


Trp Val Glu Gln Leu Lys Val Gly Val Leu Val Asp Glu Val Ile Cys 
            580                 585                 590         


Lys Ala Pro Lys Lys Phe Ala Glu Thr Asp Met Arg Ser Ile Lys Ser 
        595                 600                 605             


Glu Leu Leu Cys Pro Asp Tyr Ser Asp Val Val Val Ser Thr Pro Thr 
    610                 615                 620                 


Pro Ser Ser Ile Gln Val Pro Ala Arg Thr Ser Ala Val Thr Pro Ala 
625                 630                 635                 640 


Val Arg Leu Asn Ser Thr Gly Ala Pro Ala Ser Leu Gly Ala Gly Gly 
                645                 650                 655     


Gly Ala Ser Ser Val Pro Leu Ser Val Leu Ile Leu Ser Leu Leu Leu 
            660                 665                 670         


Val Phe Ile Met Ser Val Phe Val Ala Ala Gly Leu Phe Val Leu Val 
        675                 680                 685             


Met Lys Arg Arg Lys Lys Asn Gln Ser Asp His Thr Ser Thr Asn Asn 
    690                 695                 700                 


Ser Asp Val Ser Ser Phe Asn Met Gln Tyr Ser Val Tyr Gly Gly Gly 
705                 710                 715                 720 


Gly Gly Thr Gly Gly His Pro His Ala His Val His His Arg Gly Pro 
                725                 730                 735     


Ala Leu Pro Lys Val Lys Thr Pro Ala Gly His Val Tyr Glu Tyr Ile 
            740                 745                 750         


Pro His Pro Leu Gly His Met Cys Lys Asn Pro Ile Tyr Arg Ser Arg 
        755                 760                 765             


Glu Gly Asn Ser Val Glu Asp Tyr Lys Asp Leu His Glu Leu Lys Val 
    770                 775                 780                 


Thr Tyr Ser Ser Asn His His Leu Gln Gln Gln Gln Gln Pro Pro Pro 
785                 790                 795                 800 


Pro Pro Gln Gln Pro Gln Gln Gln Pro Pro Pro Gln Leu Gln Leu Gln 
                805                 810                 815     


Pro Gly Glu Glu Glu Arg Arg Glu Ser His His Leu Arg Ser Pro Ala 
            820                 825                 830         


Tyr Ser Val Ser Thr Ile Glu Pro Arg Glu Asp Leu Leu Ser Pro Val 
        835                 840                 845             


Gln Asp Ala Asp Arg Phe Tyr Arg Gly Ile Leu Glu Pro Asp Lys His 
    850                 855                 860                 


Cys Ser Thr Thr Pro Ala Gly Asn Ser Leu Pro Glu Tyr Pro Lys Phe 
865                 870                 875                 880 


Pro Cys Ser Pro Ala Ala Tyr Thr Phe Ser Pro Asn Tyr Asp Leu Arg 
                885                 890                 895     


Arg Pro His Gln Tyr Leu His Pro Gly Ala Gly Asp Ser Arg Leu Arg 
            900                 905                 910         


Glu Pro Val Leu Tyr Ser Pro Pro Ser Ala Val Phe Val Glu Pro Asn 
        915                 920                 925             


Arg Asn Glu Tyr Leu Glu Leu Lys Ala Lys Leu Asn Val Glu Pro Asp 
    930                 935                 940                 


Tyr Leu Glu Val Leu Glu Lys Gln Thr Thr Phe Ser Gln Phe 
945                 950                 955             


<210>  4104
<211>  1237
<212>  PRT
<213>  Homo sapiens

<400>  4104

Met Ser Val Leu Thr Ser Pro Arg Gly Lys Val Glu Val Val His Cys 
1               5                   10                  15      


Arg Arg Thr Glu Ser Gln Asp Val Tyr Cys Ile Lys Ser Leu Ile Arg 
            20                  25                  30          


Lys Phe Thr Cys Lys Leu Phe Gly Lys Leu Asn Ile Ile Tyr Leu Leu 
        35                  40                  45              


Glu Lys Ala Asn Leu Ala Val Thr Leu Cys Asn Asp Lys Glu Glu Ile 
    50                  55                  60                  


Met Ala Gln Ala Thr Phe Leu Asp Tyr Pro Asn Trp Asn Val Ala Lys 
65                  70                  75                  80  


Gln Asp Asp Trp Val Ser Val Phe Arg Glu Leu Asp Ser Asp Ile Pro 
                85                  90                  95      


Cys Thr Pro Leu Asn Thr Leu Phe Met His Leu Phe Val Ala Val Asp 
            100                 105                 110         


Glu Tyr Ser Val Gly Cys Cys Lys Glu Ile Leu Arg Thr Val Tyr Lys 
        115                 120                 125             


Ala Val Pro Glu Leu His Phe Ile Phe Leu Ile Val Pro Ser Tyr Met 
    130                 135                 140                 


Ser Leu Gly Ser Thr Leu Ile Thr Val Phe Asp Gln Val Gly Asn Ile 
145                 150                 155                 160 


Pro Cys Leu Thr Tyr Glu Glu Asp Phe Ala Val His Ile Cys His Arg 
                165                 170                 175     


His Ser His Tyr Pro Gln Leu His Val Arg Lys Ala Arg Val Glu Asp 
            180                 185                 190         


His Asp Asp Leu Met Pro Ile Phe Met Arg Tyr Asp Thr Ile Leu Lys 
        195                 200                 205             


Glu Thr Tyr Gly Glu Tyr Phe Leu Ala Glu Leu Ile Glu Ala Gln Asp 
    210                 215                 220                 


Glu Glu Asn His Ala Val Val Cys Glu Val Glu Gly Thr Ala Val Gly 
225                 230                 235                 240 


Phe Met Ser Val Cys Ser Arg Val Asn Met Gln Leu Leu His Glu Cys 
                245                 250                 255     


Phe Asp Leu Gly Pro Phe His Gly Leu Cys Phe Pro His Pro Asp Asp 
            260                 265                 270         


Val Leu Glu Ser Pro Gln Asp Leu Ser Val Arg Arg Ser Gln Asp Ala 
        275                 280                 285             


Glu Leu Arg Ser Ser Ser Gln Gly Ser Gln Lys Ile Val Glu Glu Leu 
    290                 295                 300                 


Gln Glu Pro Val Ser Pro Asp Thr Met Glu Asn Ile Gln Gly Asn Ile 
305                 310                 315                 320 


Ala Arg Glu Ala Ala Ser Glu Glu Ala Leu Thr Ala Val Gln Ser Gly 
                325                 330                 335     


Asn Val Ser Glu Pro Glu Asp Ile Glu Lys Leu Ser Asp Ile Ser Thr 
            340                 345                 350         


Gly Tyr Ala Gln Tyr His His Val Ser Ser Arg Ser Leu Ala Ser Leu 
        355                 360                 365             


Val Leu Pro Glu Glu Pro Val His Phe Arg Pro Ile Tyr Arg Gly Ala 
    370                 375                 380                 


Ser Ala Ala Phe Cys Ile Gln Leu Phe Cys Ile Asp Glu Lys Tyr Glu 
385                 390                 395                 400 


Ala Arg Ser Leu Asp Phe Met Asn Phe Val Phe Ser Leu Phe Ser Asp 
                405                 410                 415     


Lys Asn Phe Cys Val Ile Ser Leu Pro His Leu Thr Pro Glu Phe Phe 
            420                 425                 430         


Leu Ile Gln Asn Phe Val Lys Met Val Pro Phe Asn Thr Cys Thr Leu 
        435                 440                 445             


Glu Gln Asp Leu Tyr Val Phe His Arg Ala Gly Leu Leu Lys Ser Ile 
    450                 455                 460                 


Asn Ile Arg Phe Ala Thr Leu Leu Asp Thr Pro Gly Val Glu Asn Leu 
465                 470                 475                 480 


Val Ser Thr Leu Met Leu Asn Lys Ser Ile Leu Glu Asp Leu Asp Arg 
                485                 490                 495     


Tyr Asn Lys Ala Arg Lys Asp Pro Asp Gly Thr Leu Leu Gln Ala Phe 
            500                 505                 510         


Val Ala Glu Val Ala Glu Gln Ile Val Gly Ile Ala Val Ile Arg Asn 
        515                 520                 525             


Glu Met Asp Ile Glu Tyr Ile Arg Ser His Tyr Asn Ile Glu Asp Phe 
    530                 535                 540                 


Ile Tyr Phe Ser His His Gln Arg Glu Glu His Gly His Met His His 
545                 550                 555                 560 


Phe Ala Leu Asn Pro Ile Phe Arg His Tyr Thr Lys Phe Phe Leu Lys 
                565                 570                 575     


Glu Ile Leu Arg Leu Gly Phe Lys Ser Cys Leu Tyr Tyr Arg Val Tyr 
            580                 585                 590         


Pro Lys Ser Arg Glu Gly Lys Phe Gln Asn Pro Tyr Ala His Ser Leu 
        595                 600                 605             


Thr Ser Ala Leu His Tyr Leu Val Pro Val Arg Pro Arg Arg Gln Ile 
    610                 615                 620                 


Val Tyr Pro Leu Glu Lys Leu Gly Ile Asn Ala Pro Ser Lys Ala Val 
625                 630                 635                 640 


Ser Lys Asp Pro Met Ser Tyr Ala Leu Asn His Thr Asn Arg Lys Leu 
                645                 650                 655     


Thr Leu Glu Pro Lys Ile Thr Val Asn Ala Lys Ile Ile Val Val Gly 
            660                 665                 670         


Ala Ser Ser Val Gly Ile Ser Phe Leu Glu Thr Leu Val Phe Cys Ser 
        675                 680                 685             


His Met Lys Phe Asn Asn Leu Thr Leu Ile Ser Thr His Gly Leu Pro 
    690                 695                 700                 


Gly Lys Lys Leu Leu Asp Thr Glu Gln Arg Lys Phe Leu Ala Ser Asp 
705                 710                 715                 720 


His Cys Phe Asn Asp Lys Asp Tyr Ala Leu Met Ser Leu Cys Ser Trp 
                725                 730                 735     


Val Asn Val Val Val Gly Arg Met Thr Gly Ile Asp Arg Ala Ala Lys 
            740                 745                 750         


His Val Val Leu Ser Thr Asp Glu Ile Val Pro Tyr Asp His Leu Ile 
        755                 760                 765             


Leu Cys Thr Gly Gln Gln Tyr Gln Val Pro Cys Pro Thr Glu Ala Asp 
    770                 775                 780                 


Ile Ser Gln His Leu Thr Asn Arg Glu Val Pro Asn Ser Ser Gln Arg 
785                 790                 795                 800 


Arg Tyr Thr Gly Lys Val Pro Cys Asn His Phe Thr Leu Asn Glu Glu 
                805                 810                 815     


Glu Asp Cys Phe Lys Ala Leu Ile Trp Ile Arg Asn Asn Ser Ile Thr 
            820                 825                 830         


Thr Glu Gly Asn Ile Ile Val Tyr Gly Asn Thr Ile Asp Thr Tyr Thr 
        835                 840                 845             


Thr Val Glu Thr Leu Leu Asn Leu Gly Val Ser Gly Ser Arg Ile His 
    850                 855                 860                 


Leu Val Gln Pro Pro Pro Ala Ser Thr Ile Thr Cys Ile Asn Asn Tyr 
865                 870                 875                 880 


Ser Val Glu Ser Ala Val Ala Asp Ala Leu Gly Ala Ala Gly Val Thr 
                885                 890                 895     


Met Tyr Arg Asp Ala Ile Leu Ala Gln Trp Asn Asp Gly Leu His Pro 
            900                 905                 910         


Asp Pro Ile Tyr Ser Ala Ser Phe Thr Thr Pro Thr Lys Pro Phe Arg 
        915                 920                 925             


Leu Gln Cys Ser Met Phe Phe Ser Phe Cys Glu Lys Asn Val Asp Tyr 
    930                 935                 940                 


Glu Thr Phe Lys Ala Leu Asn Asp Ala Cys Leu Val Tyr Asp Ser Arg 
945                 950                 955                 960 


Leu Val Ile Asp Thr Asn Phe His Thr Asn Asp Ile Ala Ile Arg Ala 
                965                 970                 975     


Ala Gly Ser Leu Thr Lys Phe Ser Asn Arg Tyr Tyr Ser Asn Glu Trp 
            980                 985                 990         


Thr His Ser Asn Phe Ser Ser Lys  Glu Ile Gly Phe Gln  Leu Ala Ala 
        995                 1000                 1005             


Ala Met  Leu His Leu Phe Asp  Pro Thr Leu Glu Pro  Val Thr Glu 
    1010                 1015                 1020             


Pro Pro  Ala Asn Leu Asp Arg  Leu Ile Pro Met Tyr  Lys Gly Ala 
    1025                 1030                 1035             


Lys Ile  Gln Gly Gly Ile Leu  Pro Gly Ser Tyr His  Tyr Leu His 
    1040                 1045                 1050             


Ile Ala  Lys Pro Ala Ile Pro  Thr Pro Leu Glu Val  Gln Met Ala 
    1055                 1060                 1065             


Gln Pro  Asn Tyr Gly Leu Glu  Leu Val Thr Gly Ser  Ala Lys Asn 
    1070                 1075                 1080             


Gly Thr  Tyr Phe Arg Ile His  Ile Asn Lys Tyr Lys  Met Val Glu 
    1085                 1090                 1095             


Thr Ile  Thr Cys Leu Ser Arg  Glu Pro Phe Pro Ala  Ser Asn Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Gly Gln His  Glu Gln Leu Leu Asn  Asn Leu Cys 
    1115                 1120                 1125             


Ala Arg  Tyr Asp Glu Asn Leu  Ile Thr Asp Leu Tyr  Ser Tyr Phe 
    1130                 1135                 1140             


Thr Glu  Pro Trp Cys Leu Ala  Leu Phe His Asp Arg  Phe Ile Asp 
    1145                 1150                 1155             


Leu Arg  Lys Glu Leu Arg Gln  Ile Leu Ala Ser Lys  Glu Glu Glu 
    1160                 1165                 1170             


Asp Leu  Pro Ser Ile Glu Gln  Leu Ala His Gln Ile  Glu Asp Glu 
    1175                 1180                 1185             


Glu Ile  Asn Pro Thr Glu Lys  Pro Arg Gln Tyr Leu  Lys Arg Val 
    1190                 1195                 1200             


Phe Glu  Glu Ser Ile Tyr Lys  Thr Leu Val Glu Arg  Ser Thr Leu 
    1205                 1210                 1215             


Asp Tyr  Leu His Tyr Asn Arg  Tyr His Leu Pro Met  Tyr Ala Trp 
    1220                 1225                 1230             


Pro Gly  Ile Val 
    1235         


<210>  4105
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  4105

Met Arg Lys Arg Thr Glu Pro Val Ala Leu Glu His Glu Arg Cys Ala 
1               5                   10                  15      


Ala Ala Gly Ser Ser Ser Ser Gly Ser Ala Ala Ala Ala Leu Asp Ala 
            20                  25                  30          


Asp Cys Arg Leu Lys Gln Asn Leu Arg Leu Thr Gly Pro Ala Ala Ala 
        35                  40                  45              


Glu Pro Arg Cys Ala Ala Asp Ala Gly Met Lys Arg Ala Leu Gly Arg 
    50                  55                  60                  


Arg Lys Gly Val Trp Leu Arg Leu Arg Lys Ile Leu Phe Cys Val Leu 
65                  70                  75                  80  


Gly Leu Tyr Ile Ala Ile Pro Phe Leu Ile Lys Leu Cys Pro Gly Ile 
                85                  90                  95      


Gln Ala Lys Leu Ile Phe Leu Asn Phe Val Arg Val Pro Tyr Phe Ile 
            100                 105                 110         


Asp Leu Lys Lys Pro Gln Asp Gln Gly Leu Asn His Thr Cys Asn Tyr 
        115                 120                 125             


Tyr Leu Gln Pro Glu Glu Asp Val Thr Ile Gly Val Trp His Thr Val 
    130                 135                 140                 


Pro Ala Val Trp Trp Lys Asn Ala Gln Gly Lys Asp Gln Met Trp Tyr 
145                 150                 155                 160 


Glu Asp Ala Leu Ala Ser Ser His Pro Ile Ile Leu Tyr Leu His Gly 
                165                 170                 175     


Asn Ala Gly Thr Arg Gly Gly Asp His Arg Val Glu Leu Tyr Lys Val 
            180                 185                 190         


Leu Ser Ser Leu Gly Tyr His Val Val Thr Phe Asp Tyr Arg Gly Trp 
        195                 200                 205             


Gly Asp Ser Val Gly Thr Pro Ser Glu Arg Gly Met Thr Tyr Asp Ala 
    210                 215                 220                 


Leu His Val Phe Asp Trp Ile Lys Ala Arg Ser Gly Asp Asn Pro Val 
225                 230                 235                 240 


Tyr Ile Trp Gly His Ser Leu Gly Thr Gly Val Ala Thr Asn Leu Val 
                245                 250                 255     


Arg Arg Leu Cys Glu Arg Glu Thr Pro Pro Asp Ala Leu Ile Leu Glu 
            260                 265                 270         


Ser Pro Phe Thr Asn Ile Arg Glu Glu Ala Lys Ser His Pro Phe Ser 
        275                 280                 285             


Val Ile Tyr Arg Tyr Phe Pro Gly Phe Asp Trp Phe Phe Leu Asp Pro 
    290                 295                 300                 


Ile Thr Ser Ser Gly Ile Lys Phe Ala Asn Asp Glu Asn Val Lys His 
305                 310                 315                 320 


Ile Ser Cys Pro Leu Leu Ile Leu His Ala Glu Asp Asp Pro Val Val 
                325                 330                 335     


Pro Phe Gln Leu Gly Arg Lys Leu Tyr Ser Ile Ala Ala Pro Ala Arg 
            340                 345                 350         


Ser Phe Arg Asp Phe Lys Val Gln Phe Val Pro Phe His Ser Asp Leu 
        355                 360                 365             


Gly Tyr Arg His Lys Tyr Ile Tyr Lys Ser Pro Glu Leu Pro Arg Ile 
    370                 375                 380                 


Leu Arg Pro Gln Gln Gly Pro Gly Ser Ser Pro Asp Pro Ser Met Trp 
385                 390                 395                 400 


Ser Glu Leu Val 
                


<210>  4106
<211>  1049
<212>  PRT
<213>  Homo sapiens

<400>  4106

Met Leu Cys Trp Gly Asn Ala Ser Phe Gly Gln Leu Gly Leu Gly Gly 
1               5                   10                  15      


Ile Asp Glu Glu Ile Val Leu Glu Pro Arg Lys Ser Asp Phe Phe Ile 
            20                  25                  30          


Asn Lys Arg Val Arg Asp Val Gly Cys Gly Leu Arg His Thr Val Phe 
        35                  40                  45              


Val Leu Asp Asp Gly Thr Val Tyr Thr Cys Gly Cys Asn Asp Leu Gly 
    50                  55                  60                  


Gln Leu Gly His Glu Lys Ser Arg Lys Lys Pro Glu Gln Val Val Ala 
65                  70                  75                  80  


Leu Asp Ala Gln Asn Ile Val Ala Val Ser Cys Gly Glu Ala His Thr 
                85                  90                  95      


Leu Ala Leu Asn Asp Lys Gly Gln Val Tyr Ala Trp Gly Leu Asp Ser 
            100                 105                 110         


Asp Gly Gln Leu Gly Leu Val Gly Ser Glu Glu Cys Ile Arg Val Pro 
        115                 120                 125             


Arg Asn Ile Lys Ser Leu Ser Asp Ile Gln Ile Val Gln Val Ala Cys 
    130                 135                 140                 


Gly Tyr Tyr His Ser Leu Ala Leu Ser Lys Ala Ser Glu Val Phe Cys 
145                 150                 155                 160 


Trp Gly Gln Asn Lys Tyr Gly Gln Leu Gly Leu Gly Thr Asp Cys Lys 
                165                 170                 175     


Lys Gln Thr Ser Pro Gln Leu Leu Lys Ser Leu Leu Gly Ile Pro Phe 
            180                 185                 190         


Met Gln Val Ala Ala Gly Gly Ala His Ser Phe Val Leu Thr Leu Ser 
        195                 200                 205             


Gly Ala Ile Phe Gly Trp Gly Arg Asn Lys Phe Gly Gln Leu Gly Leu 
    210                 215                 220                 


Asn Asp Glu Asn Asp Arg Tyr Val Pro Asn Leu Leu Lys Ser Leu Arg 
225                 230                 235                 240 


Ser Gln Lys Ile Val Tyr Ile Cys Cys Gly Glu Asp His Thr Ala Ala 
                245                 250                 255     


Leu Thr Lys Glu Gly Gly Val Phe Thr Phe Gly Ala Gly Gly Tyr Gly 
            260                 265                 270         


Gln Leu Gly His Asn Ser Thr Ser His Glu Ile Asn Pro Arg Lys Val 
        275                 280                 285             


Phe Glu Leu Met Gly Ser Ile Val Thr Glu Ile Ala Cys Gly Arg Gln 
    290                 295                 300                 


His Thr Ser Ala Phe Val Pro Ser Ser Gly Arg Ile Tyr Ser Phe Gly 
305                 310                 315                 320 


Leu Gly Gly Asn Gly Gln Leu Gly Thr Gly Ser Thr Ser Asn Arg Lys 
                325                 330                 335     


Ser Pro Phe Thr Val Lys Gly Asn Trp Tyr Pro Tyr Asn Gly Gln Cys 
            340                 345                 350         


Leu Pro Asp Ile Asp Ser Glu Glu Tyr Phe Cys Val Lys Arg Ile Phe 
        355                 360                 365             


Ser Gly Gly Asp Gln Ser Phe Ser His Tyr Ser Ser Pro Gln Asn Cys 
    370                 375                 380                 


Gly Pro Pro Asp Asp Phe Arg Cys Pro Asn Pro Thr Lys Gln Ile Trp 
385                 390                 395                 400 


Thr Val Asn Glu Ala Leu Ile Gln Lys Trp Leu Ser Tyr Pro Ser Gly 
                405                 410                 415     


Arg Phe Pro Val Glu Ile Ala Asn Glu Ile Asp Gly Thr Phe Ser Ser 
            420                 425                 430         


Ser Gly Cys Leu Asn Gly Ser Phe Leu Ala Val Ser Asn Asp Asp His 
        435                 440                 445             


Tyr Arg Thr Gly Thr Arg Phe Ser Gly Val Asp Met Asn Ala Ala Arg 
    450                 455                 460                 


Leu Leu Phe His Lys Leu Ile Gln Pro Asp His Pro Gln Ile Ser Gln 
465                 470                 475                 480 


Gln Val Ala Ala Ser Leu Glu Lys Asn Leu Ile Pro Lys Leu Thr Ser 
                485                 490                 495     


Ser Leu Pro Asp Val Glu Ala Leu Arg Phe Tyr Leu Thr Leu Pro Glu 
            500                 505                 510         


Cys Pro Leu Met Ser Asp Ser Asn Asn Phe Thr Thr Ile Ala Ile Pro 
        515                 520                 525             


Phe Gly Thr Ala Leu Val Asn Leu Glu Lys Ala Pro Leu Lys Val Leu 
    530                 535                 540                 


Glu Asn Trp Trp Ser Val Leu Glu Pro Pro Leu Phe Leu Lys Ile Val 
545                 550                 555                 560 


Glu Leu Phe Lys Glu Val Val Val His Leu Leu Lys Leu Tyr Lys Ile 
                565                 570                 575     


Gly Ile Pro Pro Ser Glu Arg Arg Ile Phe Asn Ser Phe Leu His Thr 
            580                 585                 590         


Ala Leu Lys Val Leu Glu Ile Leu His Arg Val Asn Glu Lys Met Gly 
        595                 600                 605             


Gln Ile Ile Gln Tyr Asp Lys Phe Tyr Ile His Glu Val Gln Glu Leu 
    610                 615                 620                 


Ile Asp Ile Arg Asn Asp Tyr Ile Asn Trp Val Gln Gln Gln Ala Tyr 
625                 630                 635                 640 


Gly Met Leu Ala Asp Ile Pro Val Thr Ile Cys Thr Tyr Pro Phe Val 
                645                 650                 655     


Phe Asp Ala Gln Ala Lys Thr Thr Leu Leu Gln Thr Asp Ala Val Leu 
            660                 665                 670         


Gln Met Gln Met Ala Ile Asp Gln Ala His Arg Gln Asn Val Ser Ser 
        675                 680                 685             


Leu Phe Leu Pro Val Ile Glu Ser Val Asn Pro Cys Leu Ile Leu Val 
    690                 695                 700                 


Val Arg Arg Glu Asn Ile Val Gly Asp Ala Met Glu Val Leu Arg Lys 
705                 710                 715                 720 


Thr Lys Asn Ile Asp Tyr Lys Lys Pro Leu Lys Val Ile Phe Val Gly 
                725                 730                 735     


Glu Asp Ala Val Asp Ala Gly Gly Val Arg Lys Glu Phe Phe Leu Leu 
            740                 745                 750         


Ile Met Arg Glu Leu Leu Asp Pro Lys Tyr Gly Met Phe Arg Tyr Tyr 
        755                 760                 765             


Glu Asp Ser Arg Leu Ile Trp Phe Ser Asp Lys Thr Phe Glu Asp Ser 
    770                 775                 780                 


Asp Leu Phe His Leu Ile Gly Val Ile Cys Gly Leu Ala Ile Tyr Asn 
785                 790                 795                 800 


Cys Thr Ile Val Asp Leu His Phe Pro Leu Ala Leu Tyr Lys Lys Leu 
                805                 810                 815     


Leu Lys Lys Lys Pro Ser Leu Asp Asp Leu Lys Glu Leu Met Pro Asp 
            820                 825                 830         


Val Gly Arg Ser Met Gln Gln Leu Leu Asp Tyr Pro Glu Asp Asp Ile 
        835                 840                 845             


Glu Glu Thr Phe Cys Leu Asn Phe Thr Ile Thr Val Glu Asn Phe Gly 
    850                 855                 860                 


Ala Thr Glu Val Lys Glu Leu Val Leu Asn Gly Ala Asp Thr Ala Val 
865                 870                 875                 880 


Asn Lys Gln Asn Arg Gln Glu Phe Val Asp Ala Tyr Val Asp Tyr Ile 
                885                 890                 895     


Phe Asn Lys Ser Val Ala Ser Leu Phe Asp Ala Phe His Ala Gly Phe 
            900                 905                 910         


His Lys Val Cys Gly Gly Lys Val Leu Leu Leu Phe Gln Pro Asn Glu 
        915                 920                 925             


Leu Gln Ala Met Val Ile Gly Asn Thr Asn Tyr Asp Trp Lys Glu Leu 
    930                 935                 940                 


Glu Lys Asn Thr Glu Tyr Lys Gly Glu Tyr Trp Ala Glu His Pro Thr 
945                 950                 955                 960 


Ile Lys Ile Phe Trp Glu Val Phe His Glu Leu Pro Leu Glu Lys Lys 
                965                 970                 975     


Lys Gln Phe Leu Leu Phe Leu Thr Gly Ser Asp Arg Ile Pro Ile Leu 
            980                 985                 990         


Gly Met Lys Ser Leu Lys Leu Val  Ile Gln Ser Thr Gly  Gly Gly Glu 
        995                 1000                 1005             


Glu Tyr  Leu Pro Val Ser His  Thr Cys Phe Asn Leu  Leu Asp Leu 
    1010                 1015                 1020             


Pro Lys  Tyr Thr Glu Lys Glu  Thr Leu Arg Ser Lys  Leu Ile Gln 
    1025                 1030                 1035             


Ala Ile  Asp His Asn Glu Gly  Phe Ser Leu Ile 
    1040                 1045                 


<210>  4107
<211>  623
<212>  PRT
<213>  Homo sapiens

<400>  4107

Met Arg Val Ala Leu Gly Met Leu Trp Leu Leu Ala Leu Ala Trp Pro 
1               5                   10                  15      


Pro Gln Ala Arg Gly Phe Cys Pro Ser Gln Cys Ser Cys Ser Leu His 
            20                  25                  30          


Ile Met Gly Asp Gly Ser Lys Ala Arg Thr Val Val Cys Asn Asp Pro 
        35                  40                  45              


Asp Met Thr Leu Pro Pro Ala Ser Ile Pro Pro Asp Thr Ser Arg Leu 
    50                  55                  60                  


Arg Leu Glu Arg Thr Ala Ile Arg Arg Val Pro Gly Glu Ala Phe Arg 
65                  70                  75                  80  


Pro Leu Gly Arg Leu Glu Gln Leu Trp Leu Pro Tyr Asn Ala Leu Ser 
                85                  90                  95      


Glu Leu Asn Ala Leu Met Leu Arg Gly Leu Arg Arg Leu Arg Glu Leu 
            100                 105                 110         


Arg Leu Pro Gly Asn Arg Leu Ala Ala Phe Pro Trp Ala Ala Leu Arg 
        115                 120                 125             


Asp Ala Pro Lys Leu Arg Leu Leu Asp Leu Gln Ala Asn Arg Leu Ser 
    130                 135                 140                 


Ala Val Pro Ala Glu Ala Ala Arg Phe Leu Glu Asn Leu Thr Phe Leu 
145                 150                 155                 160 


Asp Leu Ser Ser Asn Gln Leu Met Arg Leu Pro Gln Glu Leu Ile Val 
                165                 170                 175     


Ser Trp Ala His Leu Glu Thr Gly Ile Phe Pro Pro Gly His His Pro 
            180                 185                 190         


Arg Arg Val Leu Gly Leu Gln Asp Asn Pro Trp Ala Cys Asp Cys Arg 
        195                 200                 205             


Leu Tyr Asp Leu Val His Leu Leu Asp Gly Trp Ala Pro Asn Leu Ala 
    210                 215                 220                 


Phe Ile Glu Thr Glu Leu Arg Cys Ala Ser Pro Arg Ser Leu Ala Gly 
225                 230                 235                 240 


Val Ala Phe Ser Gln Leu Glu Leu Arg Lys Cys Gln Gly Pro Glu Leu 
                245                 250                 255     


His Pro Gly Val Ala Ser Ile Arg Ser Leu Leu Gly Gly Thr Ala Leu 
            260                 265                 270         


Leu Arg Cys Gly Ala Thr Gly Val Pro Gly Pro Glu Met Ser Trp Arg 
        275                 280                 285             


Arg Ala Asn Gly Arg Pro Leu Asn Gly Thr Val His Gln Glu Val Ser 
    290                 295                 300                 


Ser Asp Gly Thr Ser Trp Thr Leu Leu Gly Leu Pro Ala Val Ser His 
305                 310                 315                 320 


Leu Asp Ser Gly Asp Tyr Ile Cys Gln Ala Lys Asn Phe Leu Gly Ala 
                325                 330                 335     


Ser Glu Thr Val Ile Ser Leu Ile Val Thr Glu Pro Pro Thr Ser Thr 
            340                 345                 350         


Glu His Ser Gly Ser Pro Gly Ala Leu Trp Ala Arg Thr Gly Gly Gly 
        355                 360                 365             


Gly Glu Ala Ala Ala Tyr Asn Asn Lys Leu Val Ala Arg His Val Pro 
    370                 375                 380                 


Gln Ile Pro Lys Pro Ala Val Leu Ala Thr Gly Pro Ser Val Pro Ser 
385                 390                 395                 400 


Thr Lys Glu Glu Leu Thr Leu Glu His Phe Gln Met Asp Ala Leu Gly 
                405                 410                 415     


Glu Leu Ser Asp Gly Arg Ala Gly Pro Ser Glu Ala Arg Met Val Arg 
            420                 425                 430         


Ser Val Lys Val Val Gly Asp Thr Tyr His Ser Val Ser Leu Val Trp 
        435                 440                 445             


Lys Ala Pro Gln Ala Lys Asn Thr Thr Ala Phe Ser Val Leu Tyr Ala 
    450                 455                 460                 


Val Phe Gly Gln His Ser Met Arg Arg Val Ile Val Gln Pro Gly Lys 
465                 470                 475                 480 


Thr Arg Val Thr Ile Thr Gly Leu Leu Pro Lys Thr Lys Tyr Val Ala 
                485                 490                 495     


Cys Val Cys Val Gln Gly Leu Val Pro Arg Lys Glu Gln Cys Val Ile 
            500                 505                 510         


Phe Ser Thr Asn Glu Val Val Asp Ala Glu Asn Thr Gln Gln Leu Ile 
        515                 520                 525             


Asn Val Val Val Ile Ser Val Ala Ile Val Ile Ala Leu Pro Leu Thr 
    530                 535                 540                 


Leu Leu Val Cys Cys Ser Ala Leu Gln Lys Arg Cys Arg Lys Cys Phe 
545                 550                 555                 560 


Asn Lys Asp Ser Thr Glu Ala Thr Val Thr Tyr Val Asn Leu Glu Arg 
                565                 570                 575     


Leu Gly Tyr Ser Glu Asp Gly Leu Glu Glu Leu Ser Arg His Ser Val 
            580                 585                 590         


Ser Glu Ala Asp Arg Leu Leu Ser Ala Arg Ser Ser Val Asp Phe Gln 
        595                 600                 605             


Ala Phe Gly Val Lys Gly Gly Arg Arg Ile Asn Glu Tyr Phe Cys 
    610                 615                 620             


<210>  4108
<211>  607
<212>  PRT
<213>  Homo sapiens

<400>  4108

Met Arg Thr Pro Gln Leu Ala Leu Leu Gln Val Phe Phe Leu Val Phe 
1               5                   10                  15      


Pro Asp Gly Val Arg Pro Gln Pro Ser Ser Ser Pro Ser Gly Ala Val 
            20                  25                  30          


Pro Thr Ser Leu Glu Leu Gln Arg Gly Thr Asp Gly Gly Thr Leu Gln 
        35                  40                  45              


Ser Pro Ser Glu Ala Thr Ala Thr Arg Pro Ala Val Pro Gly Leu Pro 
    50                  55                  60                  


Thr Val Val Pro Thr Leu Val Thr Pro Ser Ala Pro Gly Asn Arg Thr 
65                  70                  75                  80  


Val Asp Leu Phe Pro Val Leu Pro Ile Cys Val Cys Asp Leu Thr Pro 
                85                  90                  95      


Gly Ala Cys Asp Ile Asn Cys Cys Cys Asp Arg Asp Cys Tyr Leu Leu 
            100                 105                 110         


His Pro Arg Thr Val Phe Ser Phe Cys Leu Pro Gly Ser Val Arg Ser 
        115                 120                 125             


Ser Ser Trp Val Cys Val Asp Asn Ser Val Ile Phe Arg Ser Asn Ser 
    130                 135                 140                 


Pro Phe Pro Ser Arg Val Phe Met Asp Ser Asn Gly Ile Arg Gln Phe 
145                 150                 155                 160 


Cys Val His Val Asn Asn Ser Asn Leu Asn Tyr Phe Gln Lys Leu Gln 
                165                 170                 175     


Lys Val Asn Ala Thr Asn Phe Gln Ala Leu Ala Ala Glu Phe Gly Gly 
            180                 185                 190         


Glu Ser Phe Thr Ser Thr Phe Gln Thr Gln Ser Pro Pro Ser Phe Tyr 
        195                 200                 205             


Arg Ala Gly Asp Pro Ile Leu Thr Tyr Phe Pro Lys Trp Ser Val Ile 
    210                 215                 220                 


Ser Leu Leu Arg Gln Pro Ala Gly Val Gly Ala Gly Gly Leu Cys Ala 
225                 230                 235                 240 


Glu Ser Asn Pro Ala Gly Phe Leu Glu Ser Lys Ser Thr Thr Cys Thr 
                245                 250                 255     


Arg Phe Phe Lys Asn Leu Ala Ser Ser Cys Thr Leu Asp Ser Ala Leu 
            260                 265                 270         


Asn Ala Ala Ser Tyr Tyr Asn Phe Thr Val Leu Lys Val Pro Arg Ser 
        275                 280                 285             


Met Thr Asp Pro Gln Asn Met Glu Phe Gln Val Pro Val Ile Leu Thr 
    290                 295                 300                 


Ser Gln Ala Asn Ala Pro Leu Leu Ala Gly Asn Thr Cys Gln Asn Val 
305                 310                 315                 320 


Val Ser Gln Val Thr Tyr Glu Ile Glu Thr Asn Gly Thr Phe Gly Ile 
                325                 330                 335     


Gln Lys Val Ser Val Ser Leu Gly Gln Thr Asn Leu Thr Val Glu Pro 
            340                 345                 350         


Gly Ala Ser Leu Gln Gln His Phe Ile Leu Arg Phe Arg Ala Phe Gln 
        355                 360                 365             


Gln Ser Thr Ala Ala Ser Leu Thr Ser Pro Arg Ser Gly Asn Pro Gly 
    370                 375                 380                 


Tyr Ile Val Gly Lys Pro Leu Leu Ala Leu Thr Asp Asp Ile Ser Tyr 
385                 390                 395                 400 


Ser Met Thr Leu Leu Gln Ser Gln Gly Asn Gly Ser Cys Ser Val Lys 
                405                 410                 415     


Arg His Glu Val Gln Phe Gly Val Asn Ala Ile Ser Gly Cys Lys Leu 
            420                 425                 430         


Arg Leu Lys Lys Ala Asp Cys Ser His Leu Gln Gln Glu Ile Tyr Gln 
        435                 440                 445             


Thr Leu His Gly Arg Pro Arg Pro Glu Tyr Val Ala Ile Phe Gly Asn 
    450                 455                 460                 


Ala Asp Pro Ala Gln Lys Gly Gly Trp Thr Arg Ile Leu Asn Arg His 
465                 470                 475                 480 


Cys Ser Ile Ser Ala Ile Asn Cys Thr Ser Cys Cys Leu Ile Pro Val 
                485                 490                 495     


Ser Leu Glu Ile Gln Val Leu Trp Ala Tyr Val Gly Leu Leu Ser Asn 
            500                 505                 510         


Pro Gln Ala His Val Ser Gly Val Arg Phe Leu Tyr Gln Cys Gln Ser 
        515                 520                 525             


Ile Gln Asp Ser Gln Gln Val Thr Glu Val Ser Leu Thr Thr Leu Val 
    530                 535                 540                 


Asn Phe Val Asp Ile Thr Gln Lys Pro Gln Pro Pro Arg Gly Gln Pro 
545                 550                 555                 560 


Lys Met Asp Trp Lys Trp Pro Phe Asp Phe Phe Pro Phe Lys Val Ala 
                565                 570                 575     


Phe Ser Arg Gly Val Phe Ser Gln Lys Cys Ser Val Ser Pro Ile Leu 
            580                 585                 590         


Ile Leu Cys Leu Leu Leu Leu Gly Val Leu Asn Leu Glu Thr Met 
        595                 600                 605         


<210>  4109
<211>  2277
<212>  PRT
<213>  Homo sapiens

<400>  4109

Met Phe Thr Tyr Ile Lys Ile Ile Thr Ser Gly Asp Ser Asp Asn Ile 
1               5                   10                  15      


Thr His Val Trp Asn Glu Asp Asp Gly Gln Thr Leu Ser Pro Ser Ser 
            20                  25                  30          


Leu Ala Ala Gln Leu Leu Ile Leu Glu Asn Phe Glu Asp Ala Leu Leu 
        35                  40                  45              


Asn Ile Ser Ala Asn Ser Pro Tyr Ile Pro Tyr Leu Ala Cys Val Arg 
    50                  55                  60                  


Asn Val Thr Asp Ser Leu Ala Arg Gly Ser Pro Glu Asn Leu Arg Leu 
65                  70                  75                  80  


Leu Gln Ser Thr Ile Arg Phe Lys Lys Ser Phe Leu Arg Asn Gly Ser 
                85                  90                  95      


Tyr Glu Asp Tyr Phe Pro Pro Val Pro Glu Val Leu Lys Ser Lys Leu 
            100                 105                 110         


Ser Gln Leu Arg Asn Leu Thr Glu Leu Leu Cys Glu Ser Glu Thr Phe 
        115                 120                 125             


Ser Leu Ile Glu Lys Ser Cys Gln Leu Ser Asp Met Ser Phe Gly Ser 
    130                 135                 140                 


Leu Cys Glu Glu Ser Glu Phe Asp Leu Gln Leu Leu Glu Ala Ala Glu 
145                 150                 155                 160 


Leu Gly Thr Glu Ile Ala Ala Ser Leu Leu Tyr His Asp Asn Val Ile 
                165                 170                 175     


Ser Lys Lys Val Arg Asp Leu Leu Thr Gly Asp Pro Ser Lys Ile Asn 
            180                 185                 190         


Leu Asn Met Asp Gln Phe Leu Glu Gln Ala Leu Gln Met Asn Tyr Leu 
        195                 200                 205             


Glu Asn Ile Thr Gln Leu Ile Pro Ile Ile Glu Ala Met Leu His Val 
    210                 215                 220                 


Asn Asn Ser Ala Asp Ala Ser Glu Lys Pro Gly Gln Leu Leu Glu Met 
225                 230                 235                 240 


Phe Lys Asn Val Glu Glu Leu Lys Glu Asp Leu Arg Arg Thr Thr Gly 
                245                 250                 255     


Met Ser Asn Arg Thr Ile Asp Lys Leu Leu Ala Ile Pro Ile Pro Asp 
            260                 265                 270         


Asn Arg Ala Glu Ile Ile Ser Gln Val Phe Trp Leu His Ser Cys Asp 
        275                 280                 285             


Thr Asn Ile Thr Thr Pro Lys Leu Glu Asp Ala Met Lys Glu Phe Cys 
    290                 295                 300                 


Asn Leu Ser Leu Ser Glu Arg Ser Arg Gln Ser Tyr Leu Ile Gly Leu 
305                 310                 315                 320 


Thr Leu Leu His Tyr Leu Asn Ile Tyr Asn Phe Thr Tyr Lys Val Phe 
                325                 330                 335     


Phe Pro Arg Lys Asp Gln Lys Pro Val Glu Lys Met Met Glu Leu Phe 
            340                 345                 350         


Ile Arg Leu Lys Glu Ile Leu Asn Gln Met Ala Ser Gly Thr His Pro 
        355                 360                 365             


Leu Leu Asp Lys Met Arg Ser Leu Lys Gln Met His Leu Pro Arg Ser 
    370                 375                 380                 


Val Pro Leu Thr Gln Ala Met Tyr Arg Ser Asn Arg Met Asn Thr Pro 
385                 390                 395                 400 


Gln Gly Ser Phe Ser Thr Ile Ser Gln Ala Leu Cys Ser Gln Gly Ile 
                405                 410                 415     


Thr Thr Glu Tyr Leu Thr Ala Met Leu Pro Ser Ser Gln Arg Pro Lys 
            420                 425                 430         


Gly Asn His Thr Lys Asp Phe Leu Thr Tyr Lys Leu Thr Lys Glu Gln 
        435                 440                 445             


Ile Ala Ser Lys Tyr Gly Ile Pro Ile Asn Ser Thr Pro Phe Cys Phe 
    450                 455                 460                 


Ser Leu Tyr Lys Asp Ile Ile Asn Met Pro Ala Gly Pro Val Ile Trp 
465                 470                 475                 480 


Ala Phe Leu Lys Pro Met Leu Leu Gly Arg Ile Leu Tyr Ala Pro Tyr 
                485                 490                 495     


Asn Pro Val Thr Lys Ala Ile Met Glu Lys Ser Asn Val Thr Leu Arg 
            500                 505                 510         


Gln Leu Ala Glu Leu Arg Glu Lys Ser Gln Glu Trp Met Asp Lys Ser 
        515                 520                 525             


Pro Leu Phe Met Asn Ser Phe His Leu Leu Asn Gln Ala Ile Pro Met 
    530                 535                 540                 


Leu Gln Asn Thr Leu Arg Asn Pro Phe Val Gln Val Phe Val Lys Phe 
545                 550                 555                 560 


Ser Val Gly Leu Asp Ala Val Glu Leu Leu Lys Gln Ile Asp Glu Leu 
                565                 570                 575     


Asp Ile Leu Arg Leu Lys Leu Glu Asn Asn Ile Asp Ile Ile Asp Gln 
            580                 585                 590         


Leu Asn Thr Leu Ser Ser Leu Thr Val Asn Ile Ser Ser Cys Val Leu 
        595                 600                 605             


Tyr Asp Arg Ile Gln Ala Ala Lys Thr Ile Asp Glu Met Glu Arg Glu 
    610                 615                 620                 


Ala Lys Arg Leu Tyr Lys Ser Asn Glu Leu Phe Gly Ser Val Ile Phe 
625                 630                 635                 640 


Lys Leu Pro Ser Asn Arg Ser Trp His Arg Gly Tyr Asp Ser Gly Asn 
                645                 650                 655     


Val Phe Leu Pro Pro Val Ile Lys Tyr Thr Ile Arg Met Ser Leu Lys 
            660                 665                 670         


Thr Ala Gln Thr Thr Arg Ser Leu Arg Thr Lys Ile Trp Ala Pro Gly 
        675                 680                 685             


Pro His Asn Ser Pro Ser His Asn Gln Ile Tyr Gly Arg Ala Phe Ile 
    690                 695                 700                 


Tyr Leu Gln Asp Ser Ile Glu Arg Ala Ile Ile Glu Leu Gln Thr Gly 
705                 710                 715                 720 


Arg Asn Ser Gln Glu Ile Ala Val Gln Val Gln Ala Ile Pro Tyr Pro 
                725                 730                 735     


Cys Phe Met Lys Asp Asn Phe Leu Thr Ser Val Ser Tyr Ser Leu Pro 
            740                 745                 750         


Ile Val Leu Met Val Ala Trp Val Val Phe Ile Ala Ala Phe Val Lys 
        755                 760                 765             


Lys Leu Val Tyr Glu Lys Asp Leu Arg Leu His Glu Tyr Met Lys Met 
    770                 775                 780                 


Met Gly Val Asn Ser Cys Ser His Phe Phe Ala Trp Leu Ile Glu Ser 
785                 790                 795                 800 


Val Gly Phe Leu Leu Val Thr Ile Val Ile Leu Ile Ile Ile Leu Lys 
                805                 810                 815     


Phe Gly Asn Ile Leu Pro Lys Thr Asn Gly Phe Ile Leu Phe Leu Tyr 
            820                 825                 830         


Phe Ser Asp Tyr Ser Phe Ser Val Ile Ala Met Ser Tyr Leu Ile Ser 
        835                 840                 845             


Val Phe Phe Asn Asn Thr Asn Ile Ala Ala Leu Ile Gly Ser Leu Ile 
    850                 855                 860                 


Tyr Ile Ile Ala Phe Phe Pro Phe Ile Val Leu Val Thr Val Glu Asn 
865                 870                 875                 880 


Glu Leu Ser Tyr Val Leu Lys Val Phe Met Ser Leu Leu Ser Pro Thr 
                885                 890                 895     


Ala Phe Ser Tyr Ala Ser Gln Tyr Ile Ala Arg Tyr Glu Glu Gln Gly 
            900                 905                 910         


Ile Gly Leu Gln Trp Glu Asn Met Tyr Thr Ser Pro Val Gln Asp Asp 
        915                 920                 925             


Thr Thr Ser Phe Gly Trp Leu Cys Cys Leu Ile Leu Ala Asp Ser Phe 
    930                 935                 940                 


Ile Tyr Phe Leu Ile Ala Trp Tyr Val Arg Asn Val Phe Pro Gly Thr 
945                 950                 955                 960 


Tyr Gly Met Ala Ala Pro Trp Tyr Phe Pro Ile Leu Pro Ser Tyr Trp 
                965                 970                 975     


Lys Glu Arg Phe Gly Cys Ala Glu Val Lys Pro Glu Lys Ser Asn Gly 
            980                 985                 990         


Leu Met Phe Thr Asn Ile Met Met  Gln Asn Thr Asn Pro  Ser Ala Ser 
        995                 1000                 1005             


Pro Glu  Tyr Met Phe Ser Ser  Asn Ile Glu Pro Glu  Pro Lys Asp 
    1010                 1015                 1020             


Leu Thr  Val Gly Val Ala Leu  His Gly Val Thr Lys  Ile Tyr Gly 
    1025                 1030                 1035             


Ser Lys  Val Ala Val Asp Asn  Leu Asn Leu Asn Phe  Tyr Glu Gly 
    1040                 1045                 1050             


His Ile  Thr Ser Leu Leu Gly  Pro Asn Gly Ala Gly  Lys Thr Thr 
    1055                 1060                 1065             


Thr Ile  Ser Met Leu Thr Gly  Leu Phe Gly Ala Ser  Ala Gly Thr 
    1070                 1075                 1080             


Ile Phe  Val Tyr Gly Lys Asp  Ile Lys Thr Asp Leu  His Thr Val 
    1085                 1090                 1095             


Arg Lys  Asn Met Gly Val Cys  Met Gln His Asp Val  Leu Phe Ser 
    1100                 1105                 1110             


Tyr Leu  Thr Thr Lys Glu His  Leu Leu Leu Tyr Gly  Ser Ile Lys 
    1115                 1120                 1125             


Val Pro  His Trp Thr Lys Lys  Gln Leu His Glu Glu  Val Lys Arg 
    1130                 1135                 1140             


Thr Leu  Lys Asp Thr Gly Leu  Tyr Ser His Arg His  Lys Arg Val 
    1145                 1150                 1155             


Gly Thr  Leu Ser Gly Gly Met  Lys Arg Lys Leu Ser  Ile Ser Ile 
    1160                 1165                 1170             


Ala Leu  Ile Gly Gly Ser Arg  Val Val Ile Leu Asp  Glu Pro Ser 
    1175                 1180                 1185             


Thr Gly  Val Asp Pro Cys Ser  Arg Arg Ser Ile Trp  Asp Val Ile 
    1190                 1195                 1200             


Ser Lys  Asn Lys Thr Ala Arg  Thr Ile Ile Leu Ser  Thr His His 
    1205                 1210                 1215             


Leu Asp  Glu Ala Glu Val Leu  Ser Asp Arg Ile Ala  Phe Leu Glu 
    1220                 1225                 1230             


Gln Gly  Gly Leu Arg Cys Cys  Gly Ser Pro Phe Tyr  Leu Lys Glu 
    1235                 1240                 1245             


Ala Phe  Gly Asp Gly Tyr His  Leu Thr Leu Thr Lys  Lys Lys Ser 
    1250                 1255                 1260             


Pro Asn  Leu Asn Ala Asn Ala  Val Cys Asp Thr Met  Ala Val Thr 
    1265                 1270                 1275             


Ala Met  Ile Gln Ser His Leu  Pro Glu Ala Tyr Leu  Lys Glu Asp 
    1280                 1285                 1290             


Ile Gly  Gly Glu Leu Val Tyr  Val Leu Pro Pro Phe  Ser Thr Lys 
    1295                 1300                 1305             


Val Ser  Gly Ala Tyr Leu Ser  Leu Leu Arg Ala Leu  Asp Asn Gly 
    1310                 1315                 1320             


Met Gly  Asp Leu Asn Ile Gly  Cys Tyr Gly Ile Ser  Asp Thr Thr 
    1325                 1330                 1335             


Val Glu  Glu Val Phe Leu Asn  Leu Thr Lys Glu Ser  Gln Lys Asn 
    1340                 1345                 1350             


Ser Ala  Met Ser Leu Glu His  Leu Thr Gln Lys Lys  Ile Gly Asn 
    1355                 1360                 1365             


Ser Asn  Ala Asn Gly Ile Ser  Thr Pro Asp Asp Leu  Ser Val Ser 
    1370                 1375                 1380             


Ser Ser  Asn Phe Thr Asp Arg  Asp Asp Lys Ile Leu  Thr Arg Gly 
    1385                 1390                 1395             


Glu Arg  Leu Asp Gly Phe Gly  Leu Leu Leu Lys Lys  Ile Met Ala 
    1400                 1405                 1410             


Ile Leu  Ile Lys Arg Phe His  His Thr Arg Arg Asn  Trp Lys Gly 
    1415                 1420                 1425             


Leu Ile  Ala Gln Val Ile Leu  Pro Ile Val Phe Val  Thr Thr Ala 
    1430                 1435                 1440             


Met Gly  Leu Gly Thr Leu Arg  Asn Ser Ser Asn Ser  Tyr Pro Glu 
    1445                 1450                 1455             


Ile Gln  Ile Ser Pro Ser Leu  Tyr Gly Thr Ser Glu  Gln Thr Ala 
    1460                 1465                 1470             


Phe Tyr  Ala Asn Tyr His Pro  Ser Thr Glu Ala Leu  Val Ser Ala 
    1475                 1480                 1485             


Met Trp  Asp Phe Pro Gly Ile  Asp Asn Met Cys Leu  Asn Thr Ser 
    1490                 1495                 1500             


Asp Leu  Gln Cys Leu Asn Lys  Asp Ser Leu Glu Lys  Trp Asn Thr 
    1505                 1510                 1515             


Ser Gly  Glu Pro Ile Thr Asn  Phe Gly Val Cys Ser  Cys Ser Glu 
    1520                 1525                 1530             


Asn Val  Gln Glu Cys Pro Lys  Phe Asn Tyr Ser Pro  Pro His Arg 
    1535                 1540                 1545             


Arg Thr  Tyr Ser Ser Gln Val  Ile Tyr Asn Leu Thr  Gly Gln Arg 
    1550                 1555                 1560             


Val Glu  Asn Tyr Leu Ile Ser  Thr Ala Asn Glu Phe  Val Gln Lys 
    1565                 1570                 1575             


Arg Tyr  Gly Gly Trp Ser Phe  Gly Leu Pro Leu Thr  Lys Asp Leu 
    1580                 1585                 1590             


Arg Phe  Asp Ile Thr Gly Val  Pro Ala Asn Arg Thr  Leu Ala Lys 
    1595                 1600                 1605             


Val Trp  Tyr Asp Pro Glu Gly  Tyr His Ser Leu Pro  Ala Tyr Leu 
    1610                 1615                 1620             


Asn Ser  Leu Asn Asn Phe Leu  Leu Arg Val Asn Met  Ser Lys Tyr 
    1625                 1630                 1635             


Asp Ala  Ala Arg His Gly Ile  Ile Met Tyr Ser His  Pro Tyr Pro 
    1640                 1645                 1650             


Gly Val  Gln Asp Gln Glu Gln  Ala Thr Ile Ser Ser  Leu Ile Asp 
    1655                 1660                 1665             


Ile Leu  Val Ala Leu Ser Ile  Leu Met Gly Tyr Ser  Val Thr Thr 
    1670                 1675                 1680             


Ala Ser  Phe Val Thr Tyr Val  Val Arg Glu His Gln  Thr Lys Ala 
    1685                 1690                 1695             


Lys Gln  Leu Gln His Ile Ser  Gly Ile Gly Val Thr  Cys Tyr Trp 
    1700                 1705                 1710             


Val Thr  Asn Phe Ile Tyr Asp  Met Val Phe Tyr Leu  Val Pro Val 
    1715                 1720                 1725             


Ala Phe  Ser Ile Gly Ile Ile  Ala Ile Phe Lys Leu  Pro Ala Phe 
    1730                 1735                 1740             


Tyr Ser  Glu Asn Asn Leu Gly  Ala Val Ser Leu Leu  Leu Leu Leu 
    1745                 1750                 1755             


Phe Gly  Tyr Ala Thr Phe Ser  Trp Met Tyr Leu Leu  Ala Gly Leu 
    1760                 1765                 1770             


Phe His  Glu Thr Gly Met Ala  Phe Ile Thr Tyr Val  Cys Val Asn 
    1775                 1780                 1785             


Leu Phe  Phe Gly Ile Asn Ser  Ile Val Ser Leu Ser  Val Val Tyr 
    1790                 1795                 1800             


Phe Leu  Ser Lys Glu Lys Pro  Asn Asp Pro Thr Leu  Glu Leu Ile 
    1805                 1810                 1815             


Ser Glu  Thr Leu Lys Arg Ile  Phe Leu Ile Phe Pro  Gln Phe Cys 
    1820                 1825                 1830             


Phe Gly  Tyr Gly Leu Ile Glu  Leu Ser Gln Gln Gln  Ser Val Leu 
    1835                 1840                 1845             


Asp Phe  Leu Lys Ala Tyr Gly  Val Glu Tyr Pro Asn  Glu Thr Phe 
    1850                 1855                 1860             


Glu Met  Asn Lys Leu Gly Ala  Met Phe Val Ala Leu  Val Ser Gln 
    1865                 1870                 1875             


Gly Thr  Met Phe Phe Ser Leu  Arg Leu Leu Ile Asn  Glu Ser Leu 
    1880                 1885                 1890             


Ile Lys  Lys Leu Arg Leu Phe  Phe Arg Lys Phe Asn  Ser Ser His 
    1895                 1900                 1905             


Val Arg  Glu Thr Ile Asp Glu  Asp Glu Asp Val Arg  Ala Glu Arg 
    1910                 1915                 1920             


Leu Arg  Val Glu Ser Gly Ala  Ala Glu Phe Asp Leu  Val Gln Leu 
    1925                 1930                 1935             


Tyr Cys  Leu Thr Lys Thr Tyr  Gln Leu Ile His Lys  Lys Ile Ile 
    1940                 1945                 1950             


Ala Val  Asn Asn Ile Ser Ile  Gly Ile Pro Ala Gly  Glu Cys Phe 
    1955                 1960                 1965             


Gly Leu  Leu Gly Val Asn Gly  Ala Gly Lys Thr Thr  Ile Phe Lys 
    1970                 1975                 1980             


Met Leu  Thr Gly Asp Ile Ile  Pro Ser Ser Gly Asn  Ile Leu Ile 
    1985                 1990                 1995             


Arg Asn  Lys Thr Gly Ser Leu  Gly His Val Asp Ser  His Ser Ser 
    2000                 2005                 2010             


Leu Val  Gly Tyr Cys Pro Gln  Glu Asp Ala Leu Asp  Asp Leu Val 
    2015                 2020                 2025             


Thr Val  Glu Glu His Leu Tyr  Phe Tyr Ala Arg Val  His Gly Ile 
    2030                 2035                 2040             


Pro Glu  Lys Asp Ile Lys Glu  Thr Val His Lys Leu  Leu Arg Arg 
    2045                 2050                 2055             


Leu His  Leu Met Pro Phe Lys  Asp Arg Ala Thr Ser  Met Cys Ser 
    2060                 2065                 2070             


Tyr Gly  Thr Lys Arg Lys Leu  Ser Thr Ala Leu Ala  Leu Ile Gly 
    2075                 2080                 2085             


Lys Pro  Ser Ile Leu Leu Leu  Asp Glu Pro Ser Ser  Gly Met Asp 
    2090                 2095                 2100             


Pro Lys  Ser Lys Arg His Leu  Trp Lys Ile Ile Ser  Glu Glu Val 
    2105                 2110                 2115             


Gln Asn  Lys Cys Ser Val Ile  Leu Thr Ser His Ser  Met Glu Glu 
    2120                 2125                 2130             


Cys Glu  Ala Leu Cys Thr Arg  Leu Ala Ile Met Val  Asn Gly Lys 
    2135                 2140                 2145             


Phe Gln  Cys Ile Gly Ser Leu  Gln His Ile Lys Ser  Arg Phe Gly 
    2150                 2155                 2160             


Arg Gly  Phe Thr Val Lys Val  His Leu Lys Asn Asn  Lys Val Thr 
    2165                 2170                 2175             


Met Glu  Thr Leu Thr Lys Phe  Met Gln Leu His Phe  Pro Lys Thr 
    2180                 2185                 2190             


Tyr Leu  Lys Asp Gln His Leu  Ser Met Leu Glu Tyr  His Val Pro 
    2195                 2200                 2205             


Val Thr  Ala Gly Gly Val Ala  Asn Ile Phe Asp Leu  Leu Glu Thr 
    2210                 2215                 2220             


Asn Lys  Thr Ala Leu Asn Ile  Thr Asn Phe Leu Val  Ser Gln Thr 
    2225                 2230                 2235             


Thr Leu  Glu Glu Val Phe Ile  Asn Phe Ala Lys Asp  Gln Lys Ser 
    2240                 2245                 2250             


Tyr Glu  Thr Ala Asp Thr Ser  Ser Gln Gly Ser Thr  Ile Ser Val 
    2255                 2260                 2265             


Asp Ser  Gln Asp Asp Gln Met  Glu Ser 
    2270                 2275         


<210>  4110
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  4110

Met Asp Gln Asn Glu His Ser His Trp Gly Pro His Ala Lys Gly Gln 
1               5                   10                  15      


Cys Ala Ser Arg Ser Glu Leu Arg Ile Ile Leu Val Gly Lys Thr Gly 
            20                  25                  30          


Thr Gly Lys Ser Ala Ala Gly Asn Ser Ile Leu Arg Lys Gln Ala Phe 
        35                  40                  45              


Glu Ser Lys Leu Gly Ser Gln Thr Leu Thr Lys Thr Cys Ser Lys Ser 
    50                  55                  60                  


Gln Gly Ser Trp Gly Asn Arg Glu Ile Val Ile Ile Asp Thr Pro Asp 
65                  70                  75                  80  


Met Phe Ser Trp Lys Asp His Cys Glu Ala Leu Tyr Lys Glu Val Gln 
                85                  90                  95      


Arg Cys Tyr Leu Leu Ser Ala Pro Gly Pro His Val Leu Leu Leu Val 
            100                 105                 110         


Thr Gln Leu Gly Arg Tyr Thr Ser Gln Asp Gln Gln Ala Ala Gln Arg 
        115                 120                 125             


Val Lys Glu Ile Phe Gly Glu Asp Ala Met Gly His Thr Ile Val Leu 
    130                 135                 140                 


Phe Thr His Lys Glu Asp Leu Asn Gly Gly Ser Leu Met Asp Tyr Met 
145                 150                 155                 160 


His Asp Ser Asp Asn Lys Ala Leu Ser Lys Leu Val Ala Ala Cys Gly 
                165                 170                 175     


Gly Arg Ile Cys Ala Phe Asn Asn Arg Ala Glu Gly Ser Asn Gln Asp 
            180                 185                 190         


Asp Gln Val Lys Glu Leu Met Asp Cys Ile Glu Asp Leu Leu Met Glu 
        195                 200                 205             


Lys Asn Gly Asp His Tyr Thr Asn Gly Leu Tyr Ser Leu Ile Gln Arg 
    210                 215                 220                 


Ser Lys Cys Gly Pro Val Gly Ser Asp Glu Arg Val Lys Glu Phe Lys 
225                 230                 235                 240 


Gln Ser Leu Ile Lys Tyr Met Glu Thr Gln Arg Ser Tyr Thr Ala Leu 
                245                 250                 255     


Ala Glu Ala Asn Cys Leu Lys Gly Ala Leu Ile Lys Thr Gln Leu Cys 
            260                 265                 270         


Val Leu Phe Cys Ile Gln Leu Phe Leu Arg Leu Ile Ile Leu Trp Leu 
        275                 280                 285             


Cys Ile Leu His Ser Met Cys Asn Leu Phe Cys Cys Leu Leu Phe Ser 
    290                 295                 300                 


Met Cys Asn Leu Phe Cys Ser Leu Leu Phe Ile Ile Pro Lys Lys Leu 
305                 310                 315                 320 


Met Ile Phe Leu Arg Thr Val Ile Arg Leu Glu Arg Lys Thr Pro Arg 
                325                 330                 335     


Leu 
    


<210>  4111
<211>  795
<212>  PRT
<213>  Homo sapiens

<400>  4111

Met Glu Thr Ala Leu Ala Lys Thr Pro Gln Lys Arg Gln Val Met Phe 
1               5                   10                  15      


Leu Ala Ile Leu Leu Leu Leu Trp Glu Ala Gly Ser Glu Ala Val Arg 
            20                  25                  30          


Tyr Ser Ile Pro Glu Glu Thr Glu Ser Gly Tyr Ser Val Ala Asn Leu 
        35                  40                  45              


Ala Lys Asp Leu Gly Leu Gly Val Gly Glu Leu Ala Thr Arg Gly Ala 
    50                  55                  60                  


Arg Met His Tyr Lys Gly Asn Lys Glu Leu Leu Gln Leu Asp Ile Lys 
65                  70                  75                  80  


Thr Gly Asn Leu Leu Leu Tyr Glu Lys Leu Asp Arg Glu Val Met Cys 
                85                  90                  95      


Gly Ala Thr Glu Pro Cys Ile Leu His Phe Gln Leu Leu Leu Glu Asn 
            100                 105                 110         


Pro Val Gln Phe Phe Gln Thr Asp Leu Gln Leu Thr Asp Ile Asn Asp 
        115                 120                 125             


His Ala Pro Glu Phe Pro Glu Lys Glu Met Leu Leu Lys Ile Pro Glu 
    130                 135                 140                 


Ser Thr Gln Pro Gly Thr Val Phe Pro Leu Lys Ile Ala Gln Asp Phe 
145                 150                 155                 160 


Asp Ile Gly Ser Asn Thr Val Gln Asn Tyr Thr Ile Ser Pro Asn Ser 
                165                 170                 175     


His Phe His Val Ala Thr His Asn Arg Gly Asp Gly Arg Lys Tyr Pro 
            180                 185                 190         


Glu Leu Val Leu Asp Lys Ala Leu Asp Arg Glu Glu Arg Pro Glu Leu 
        195                 200                 205             


Ser Leu Thr Leu Thr Ala Leu Asp Gly Gly Ala Pro Pro Arg Ser Gly 
    210                 215                 220                 


Thr Thr Thr Ile Arg Ile Val Val Leu Asp Asn Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Glu Phe Leu Gln Ser Phe Tyr Glu Val Gln Val Pro Glu Asn Ser Pro 
                245                 250                 255     


Leu Asn Ser Leu Val Val Val Val Ser Ala Arg Asp Leu Asp Ala Gly 
            260                 265                 270         


Ala Tyr Gly Ser Val Ala Tyr Ala Leu Phe Gln Gly Asp Glu Val Thr 
        275                 280                 285             


Gln Pro Phe Val Ile Asp Glu Lys Thr Ala Glu Ile Arg Leu Lys Arg 
    290                 295                 300                 


Ala Leu Asp Phe Glu Ala Thr Pro Tyr Tyr Asn Val Glu Ile Val Ala 
305                 310                 315                 320 


Thr Asp Gly Gly Gly Leu Ser Gly Lys Cys Thr Val Ala Ile Glu Val 
                325                 330                 335     


Val Asp Val Asn Asp Asn Ala Pro Glu Leu Thr Met Ser Thr Leu Ser 
            340                 345                 350         


Ser Pro Thr Pro Glu Asn Ala Pro Glu Thr Val Val Ala Val Phe Ser 
        355                 360                 365             


Val Ser Asp Pro Asp Ser Gly Asp Asn Gly Arg Met Ile Cys Ser Ile 
    370                 375                 380                 


Gln Asn Asp Leu Pro Phe Leu Leu Lys Pro Thr Leu Lys Asn Phe Tyr 
385                 390                 395                 400 


Thr Leu Val Thr Gln Arg Thr Leu Asp Arg Glu Ser Gln Ala Glu Tyr 
                405                 410                 415     


Asn Ile Thr Ile Thr Val Thr Asp Met Gly Thr Pro Arg Leu Lys Thr 
            420                 425                 430         


Glu His Asn Ile Thr Val Leu Val Ser Asp Val Asn Asp Asn Ala Pro 
        435                 440                 445             


Ala Phe Thr Gln Thr Ser Tyr Thr Leu Phe Val Arg Glu Asn Asn Ser 
    450                 455                 460                 


Pro Ala Leu His Ile Gly Ser Val Ser Ala Thr Asp Arg Asp Ser Gly 
465                 470                 475                 480 


Thr Asn Ala Gln Val Thr Tyr Ser Leu Leu Pro Pro Gln Asn Pro His 
                485                 490                 495     


Leu Arg Leu Ala Ser Leu Val Ser Ile Asn Ala Asp Asn Gly His Leu 
            500                 505                 510         


Phe Ala Leu Arg Ser Leu Asp Tyr Glu Ala Leu Gln Ala Phe Glu Phe 
        515                 520                 525             


Arg Val Gly Ala Thr Asp Arg Gly Ser Pro Ala Leu Ser Ser Glu Ala 
    530                 535                 540                 


Leu Val Arg Val Leu Val Leu Asp Ala Asn Asp Asn Ser Pro Phe Val 
545                 550                 555                 560 


Leu Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu Leu Val Pro 
                565                 570                 575     


Arg Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val Asp 
            580                 585                 590         


Gly Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu Lys Ala 
        595                 600                 605             


Thr Glu Pro Gly Leu Phe Ser Met Trp Ala His Asn Gly Glu Val Arg 
    610                 615                 620                 


Thr Ala Arg Leu Leu Ser Glu Arg Asp Ala Ala Lys His Arg Leu Val 
625                 630                 635                 640 


Val Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr Ala Thr 
                645                 650                 655     


Leu His Val Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr Leu Pro Leu 
            660                 665                 670         


Pro Glu Ala Ala Pro Ala Gln Ala Gln Ala Asp Ser Leu Thr Val Tyr 
        675                 680                 685             


Leu Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu Phe Ser Val 
    690                 695                 700                 


Leu Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg Ala Ala Pro 
705                 710                 715                 720 


Val Gly Arg Cys Ser Val Pro Glu Gly Pro Phe Pro Gly His Leu Val 
                725                 730                 735     


Asp Val Ser Gly Thr Gly Thr Leu Ser Gln Ser Tyr His Tyr Glu Val 
            740                 745                 750         


Cys Leu Thr Gly Asp Ser Gly Ala Gly Glu Phe Lys Phe Leu Lys Pro 
        755                 760                 765             


Ile Ile Pro Asn Leu Leu Pro Gln Gly Ala Gly Glu Glu Ile Gly Lys 
    770                 775                 780                 


Thr Ala Ala Phe Arg Asn Ser Phe Gly Leu Asn 
785                 790                 795 


<210>  4112
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  4112

Met Met Asn Phe Arg Gln Arg Met Gly Trp Ile Gly Val Gly Leu Tyr 
1               5                   10                  15      


Leu Leu Ala Ser Ala Ala Ala Phe Tyr Tyr Val Phe Glu Ile Ser Glu 
            20                  25                  30          


Thr Tyr Asn Arg Leu Ala Leu Glu His Ile Gln Gln His Pro Glu Glu 
        35                  40                  45              


Pro Leu Glu Gly Thr Thr Trp Thr His Ser Leu Lys Ala Gln Leu Leu 
    50                  55                  60                  


Ser Leu Pro Phe Trp Val Trp Thr Val Ile Phe Leu Val Pro Tyr Leu 
65                  70                  75                  80  


Gln Met Phe Leu Phe Leu Tyr Ser Cys Thr Arg Ala Asp Pro Lys Thr 
                85                  90                  95      


Val Gly Tyr Cys Ile Ile Pro Ile Cys Leu Ala Val Ile Cys Asn Arg 
            100                 105                 110         


His Gln Ala Phe Val Lys Ala Ser Asn Gln Ile Ser Arg Leu Gln Leu 
        115                 120                 125             


Ile Asp Thr 
    130     


<210>  4113
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  4113

Met Asp Leu Thr Gly Leu Leu Leu Asp Glu Glu Gly Thr Phe Ser Leu 
1               5                   10                  15      


Ala Gly Phe Gln Asp Phe Thr Phe Leu Pro Gly His Gln Lys Leu Ser 
            20                  25                  30          


Ala Arg Ile Arg Arg Arg Leu Tyr Tyr Gly Trp Asp Trp Glu Ala Asp 
        35                  40                  45              


Cys Ser Leu Glu Glu Leu Ser Ser Pro Val Ala Asp Ile Ala Val Glu 
    50                  55                  60                  


Leu Leu Gln Lys Ala Ala Pro Ser Pro Ile Arg Arg Leu Gln Lys Lys 
65                  70                  75                  80  


Tyr Val Ala His Val Ser Arg Glu Ala Cys Ile Ser Pro Cys Ala Met 
                85                  90                  95      


Met Leu Ala Leu Val Tyr Ile Glu Arg Leu Arg His Arg Asn Pro Asp 
            100                 105                 110         


Tyr Leu Gln His Val Ser Ser Ser Asp Leu Phe Leu Ile Ser Met Met 
        115                 120                 125             


Val Ala Ser Lys Tyr Leu Tyr Asp Glu Gly Glu Glu Glu Glu Val Phe 
    130                 135                 140                 


Asn Asp Glu Trp Gly Ala Ala Gly Gly Val Ala Val Pro Thr Leu Asn 
145                 150                 155                 160 


Ala Leu Glu Arg Gly Phe Leu Ser Ala Met Asp Trp His Leu Tyr Thr 
                165                 170                 175     


Asp Pro Arg Glu Ile Phe Glu Val Leu Ser Trp Leu Glu Ser Cys Val 
            180                 185                 190         


Ala Glu Gln Gln Gly Arg Trp Arg Gly Trp Tyr Thr Tyr Thr Asp Leu 
        195                 200                 205             


Cys Val Leu Leu Glu Gln Pro Thr Trp Gln Leu Ala Leu Gly Ser Leu 
    210                 215                 220                 


Cys Gln Arg Leu Val Lys Leu Ser Cys Leu Leu Ala Val Ala Tyr Val 
225                 230                 235                 240 


Ser Ser Val Ala Leu Ala Val Ala Ser Val Ala Val Ile His Gln Ser 
                245                 250                 255     


Leu Gly Leu Ser Cys Ile Pro Thr Pro Gly Pro Pro Asp Leu Gly Leu 
            260                 265                 270         


Thr Ser Arg Cys Leu Leu Glu Pro Cys Ile Pro Ser Val Pro Gln Cys 
        275                 280                 285             


Leu Pro Ser Leu Ala Asn Val Ser Ser Cys Leu Glu Gly Ser Met Gly 
    290                 295                 300                 


Leu Arg Ser Leu Trp Gly Ser Leu Leu Ala Ser Leu Thr Pro Pro Pro 
305                 310                 315                 320 


Leu Pro Pro Pro Asp Pro Pro Ala Pro Pro Thr Leu Leu His Asn Cys 
                325                 330                 335     


His Leu Cys Gln Lys Leu Gln Arg Asp Ser Pro Thr Cys His Ala Cys 
            340                 345                 350         


Leu His Pro Asn Arg Thr Val Pro Thr Ala Leu Ser Ser Pro Trp Tyr 
        355                 360                 365             


His Thr Tyr Gly Leu Ala Pro Pro Trp Pro Trp Ser Pro Val Pro Leu 
    370                 375                 380                 


Ser Leu Pro Gln Pro Gln Gln Cys Ser Leu Phe Ser Val Met Glu Leu 
385                 390                 395                 400 


Ala Arg Leu Lys Ser Phe Val Phe Pro Gly 
                405                 410 


<210>  4114
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  4114

Met Val Ala Ala Thr Val Ala Ala Ala Trp Leu Leu Leu Trp Ala Ala 
1               5                   10                  15      


Ala Cys Ala Gln Gln Glu Gln Asp Phe Tyr Asp Phe Lys Ala Val Asn 
            20                  25                  30          


Ile Arg Gly Lys Leu Val Ser Leu Glu Lys Tyr Arg Gly Ser Val Ser 
        35                  40                  45              


Leu Val Val Asn Val Ala Ser Glu Cys Gly Phe Thr Asp Gln His Tyr 
    50                  55                  60                  


Arg Ala Leu Gln Gln Leu Gln Arg Asp Leu Gly Pro His His Phe Asn 
65                  70                  75                  80  


Val Leu Ala Phe Pro Cys Asn Gln Phe Gly Gln Gln Glu Pro Asp Ser 
                85                  90                  95      


Asn Lys Glu Ile Glu Ser Phe Ala Arg Arg Thr Tyr Ser Val Ser Phe 
            100                 105                 110         


Pro Met Phe Ser Lys Ile Ala Val Thr Gly Thr Gly Ala His Pro Ala 
        115                 120                 125             


Phe Lys Tyr Leu Ala Gln Thr Ser Gly Lys Glu Pro Thr Trp Asn Phe 
    130                 135                 140                 


Trp Lys Tyr Leu Val Ala Pro Asp Gly Lys Val Val Gly Ala Trp Asp 
145                 150                 155                 160 


Pro Thr Val Ser Val Glu Glu Val Arg Pro Gln Ile Thr Ala Leu Val 
                165                 170                 175     


Arg Lys Leu Ile Leu Leu Lys Arg Glu Asp Leu 
            180                 185         


<210>  4115
<211>  421
<212>  PRT
<213>  Homo sapiens

<400>  4115

Met Thr Pro Ile Ser Gln Val Arg Met Arg Lys Gly Ser Ala His Thr 
1               5                   10                  15      


Ala Ala Gln Pro Gly Arg Leu Gly Leu His Pro Ala Gly Ala Thr Ala 
            20                  25                  30          


His Ala Cys Arg Gly Met Thr Ser Ile Arg Ala Arg Pro Gly Leu Thr 
        35                  40                  45              


Ser Ala Met Leu Gly Ser Arg Ala Ala Gly Phe Ala Arg Gly Leu Arg 
    50                  55                  60                  


Ala Val Ala Leu Ala Trp Leu Pro Gly Trp Arg Gly Arg Ser Phe Ala 
65                  70                  75                  80  


Leu Ala Arg Ala Ala Gly Ala Pro His Gly Gly Asp Leu Gln Pro Pro 
                85                  90                  95      


Ala Cys Pro Glu Pro Arg Gly Arg Gln Leu Ser Leu Ser Ala Ala Ala 
            100                 105                 110         


Val Val Asp Ser Ala Pro Arg Pro Leu Gln Pro Tyr Leu Arg Leu Met 
        115                 120                 125             


Arg Leu Asp Lys Pro Ile Gly Thr Trp Leu Leu Tyr Leu Pro Cys Thr 
    130                 135                 140                 


Trp Ser Ile Gly Leu Ala Ala Glu Pro Gly Cys Phe Pro Asp Trp Tyr 
145                 150                 155                 160 


Met Leu Ser Leu Phe Gly Thr Gly Ala Ile Leu Met Arg Gly Ala Gly 
                165                 170                 175     


Cys Thr Ile Asn Asp Met Trp Asp Gln Asp Tyr Asp Lys Lys Val Thr 
            180                 185                 190         


Arg Thr Ala Asn Arg Pro Ile Ala Ala Gly Asp Ile Ser Thr Phe Gln 
        195                 200                 205             


Ser Phe Val Phe Leu Gly Gly Gln Leu Thr Leu Ala Leu Gly Val Leu 
    210                 215                 220                 


Leu Cys Leu Asn Tyr Tyr Ser Ile Ala Leu Gly Ala Gly Ser Leu Leu 
225                 230                 235                 240 


Leu Val Ile Thr Tyr Pro Leu Met Lys Arg Ile Ser Tyr Trp Pro Gln 
                245                 250                 255     


Leu Ala Leu Gly Leu Thr Phe Asn Trp Gly Ala Leu Leu Gly Trp Ser 
            260                 265                 270         


Ala Ile Lys Gly Ser Cys Asp Pro Ser Val Cys Leu Pro Leu Tyr Phe 
        275                 280                 285             


Ser Gly Val Met Trp Thr Leu Ile Tyr Asp Thr Ile Tyr Ala His Gln 
    290                 295                 300                 


Asp Lys Arg Asp Asp Val Leu Ile Gly Leu Lys Ser Thr Ala Leu Arg 
305                 310                 315                 320 


Phe Gly Glu Asn Thr Lys Pro Trp Leu Ser Gly Phe Ser Val Ala Met 
                325                 330                 335     


Leu Gly Ala Leu Ser Leu Val Gly Val Asn Ser Gly Gln Thr Ala Pro 
            340                 345                 350         


Tyr Tyr Ala Ala Leu Gly Ala Val Gly Ala His Leu Thr His Gln Ile 
        355                 360                 365             


Tyr Thr Leu Asp Ile His Arg Pro Glu Asp Cys Trp Asn Lys Phe Ile 
    370                 375                 380                 


Ser Asn Arg Thr Leu Gly Leu Ile Val Phe Leu Gly Ile Val Leu Gly 
385                 390                 395                 400 


Asn Leu Trp Lys Glu Lys Lys Thr Asp Lys Thr Lys Lys Gly Ile Glu 
                405                 410                 415     


Asn Lys Ile Glu Asn 
            420     


<210>  4116
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  4116

Met Gly Asp Pro Glu Arg Pro Glu Ala Ala Gly Leu Asp Gln Asp Glu 
1               5                   10                  15      


Arg Ser Ser Ser Asp Thr Asn Glu Ser Glu Ile Lys Ser Asn Glu Glu 
            20                  25                  30          


Pro Leu Leu Arg Lys Ser Ser Arg Arg Phe Val Ile Phe Pro Ile Gln 
        35                  40                  45              


Tyr Pro Asp Ile Trp Lys Met Tyr Lys Gln Ala Gln Ala Ser Phe Trp 
    50                  55                  60                  


Thr Ala Glu Glu Val Asp Leu Ser Lys Asp Leu Pro His Trp Asn Lys 
65                  70                  75                  80  


Leu Lys Ala Asp Glu Lys Tyr Phe Ile Ser His Ile Leu Ala Phe Phe 
                85                  90                  95      


Ala Ala Ser Asp Gly Ile Val Asn Glu Asn Leu Val Glu Arg Phe Ser 
            100                 105                 110         


Gln Glu Val Gln Val Pro Glu Ala Arg Cys Phe Tyr Gly Phe Gln Ile 
        115                 120                 125             


Leu Ile Glu Asn Val His Ser Glu Met Tyr Ser Leu Leu Ile Asp Thr 
    130                 135                 140                 


Tyr Ile Arg Asp Pro Lys Lys Arg Glu Phe Leu Phe Asn Ala Ile Glu 
145                 150                 155                 160 


Thr Met Pro Tyr Val Lys Lys Lys Ala Asp Trp Ala Leu Arg Trp Ile 
                165                 170                 175     


Ala Asp Arg Lys Ser Thr Phe Gly Glu Arg Val Val Ala Phe Ala Ala 
            180                 185                 190         


Val Glu Gly Val Phe Phe Ser Gly Ser Phe Ala Ala Ile Phe Trp Leu 
        195                 200                 205             


Lys Lys Arg Gly Leu Met Pro Gly Leu Thr Phe Ser Asn Glu Leu Ile 
    210                 215                 220                 


Ser Arg Asp Glu Gly Leu His Cys Asp Phe Ala Cys Leu Met Phe Gln 
225                 230                 235                 240 


Tyr Leu Val Asn Lys Pro Ser Glu Glu Arg Val Arg Glu Ile Ile Val 
                245                 250                 255     


Asp Ala Val Lys Ile Glu Gln Glu Phe Leu Thr Glu Ala Leu Pro Val 
            260                 265                 270         


Gly Leu Ile Gly Met Asn Cys Ile Leu Met Lys Gln Tyr Ile Glu Phe 
        275                 280                 285             


Val Ala Asp Arg Leu Leu Val Glu Leu Gly Phe Ser Lys Val Phe Gln 
    290                 295                 300                 


Ala Glu Asn Pro Phe Asp Phe Met Glu Asn Ile Ser Leu Glu Gly Lys 
305                 310                 315                 320 


Thr Asn Phe Phe Glu Lys Arg Val Ser Glu Tyr Gln Arg Phe Ala Val 
                325                 330                 335     


Met Ala Glu Thr Thr Asp Asn Val Phe Thr Leu Asp Ala Asp Phe 
            340                 345                 350     


<210>  4117
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  4117

Met Thr Val Glu Lys Glu Ala Pro Asp Ala His Phe Thr Val Asp Lys 
1               5                   10                  15      


Gln Asn Ile Ser Leu Trp Pro Arg Glu Pro Pro Pro Lys Ser Gly Pro 
            20                  25                  30          


Ser Leu Val Pro Gly Lys Thr Pro Thr Val Arg Ala Ala Leu Ile Cys 
        35                  40                  45              


Leu Thr Leu Val Leu Val Ala Ser Val Leu Leu Gln Ala Val Leu Tyr 
    50                  55                  60                  


Pro Arg Phe Met Gly Thr Ile Ser Asp Val Lys Thr Asn Val Gln Leu 
65                  70                  75                  80  


Leu Lys Gly Arg Val Asp Asn Ile Ser Thr Leu Asp Ser Glu Ile Lys 
                85                  90                  95      


Lys Asn Ser Asp Gly Met Glu Ala Ala Gly Val Gln Ile Gln Met Val 
            100                 105                 110         


Asn Glu Ser Leu Gly Tyr Val Arg Ser Gln Phe Leu Lys Leu Lys Thr 
        115                 120                 125             


Ser Val Glu Lys Ala Asn Ala Gln Ile Gln Ile Leu Thr Arg Ser Trp 
    130                 135                 140                 


Glu Glu Val Ser Thr Leu Asn Ala Gln Ile Pro Glu Leu Lys Ser Asp 
145                 150                 155                 160 


Leu Glu Lys Ala Ser Ala Leu Asn Thr Lys Ile Arg Ala Leu Gln Gly 
                165                 170                 175     


Ser Leu Glu Asn Met Ser Lys Leu Leu Lys Arg Gln Asn Asp Ile Leu 
            180                 185                 190         


Gln Val Val Ser Gln Gly Trp Lys Tyr Phe Lys Gly Asn Phe Tyr Tyr 
        195                 200                 205             


Phe Ser Leu Ile Pro Lys Thr Trp Tyr Ser Ala Glu Gln Phe Cys Val 
    210                 215                 220                 


Ser Arg Asn Ser His Leu Thr Ser Val Thr Ser Glu Ser Glu Gln Glu 
225                 230                 235                 240 


Phe Leu Tyr Lys Thr Ala Gly Gly Leu Ile Tyr Trp Ile Gly Leu Thr 
                245                 250                 255     


Lys Ala Gly Met Glu Gly Asp Trp Ser Trp Val Asp Asp Thr Pro Phe 
            260                 265                 270         


Asn Lys Val Gln Ser Val Arg Phe Trp Ile Pro Gly Glu Pro Asn Asn 
        275                 280                 285             


Ala Gly Asn Asn Glu His Cys Gly Asn Ile Lys Ala Pro Ser Leu Gln 
    290                 295                 300                 


Ala Trp Asn Asp Ala Pro Cys Asp Lys Thr Phe Leu Phe Ile Cys Lys 
305                 310                 315                 320 


Arg Pro Tyr Val Pro Ser Glu Pro 
                325             


<210>  4118
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  4118

Met Gly Arg Leu Leu Arg Ala Ala Arg Leu Pro Pro Leu Leu Ser Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Val Gly Gly Ala Phe Leu Gly Ala Cys Val Ala 
            20                  25                  30          


Gly Ser Asp Glu Pro Gly Pro Glu Gly Leu Thr Ser Thr Ser Leu Leu 
        35                  40                  45              


Asp Leu Leu Leu Pro Thr Gly Leu Glu Pro Leu Asp Ser Glu Glu Pro 
    50                  55                  60                  


Ser Glu Thr Met Gly Leu Gly Ala Gly Leu Gly Ala Pro Gly Ser Gly 
65                  70                  75                  80  


Phe Pro Ser Glu Glu Asn Glu Glu Ser Arg Ile Leu Gln Pro Pro Gln 
                85                  90                  95      


Tyr Phe Trp Glu Glu Glu Glu Glu Leu Asn Asp Ser Ser Leu Asp Leu 
            100                 105                 110         


Gly Pro Thr Ala Asp Tyr Val Phe Pro Asp Leu Thr Glu Lys Ala Gly 
        115                 120                 125             


Ser Ile Glu Asp Thr Ser Gln Ala Gln Glu Leu Pro Asn Leu Pro Ser 
    130                 135                 140                 


Pro Leu Pro Lys Met Asn Leu Val Glu Pro Pro Trp His Met Pro Pro 
145                 150                 155                 160 


Arg Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Arg Glu Lys Glu 
                165                 170                 175     


Glu Val Glu Lys Gln Glu Glu Glu Glu Glu Glu Glu Leu Leu Pro Val 
            180                 185                 190         


Asn Gly Ser Gln Glu Glu Ala Lys Pro Gln Val Arg Asp Phe Ser Leu 
        195                 200                 205             


Thr Ser Ser Ser Gln Thr Pro Gly Ala Thr Lys Ser Arg His Glu Asp 
    210                 215                 220                 


Ser Gly Asp Gln Ala Ser Ser Gly Val Glu Val Glu Ser Ser Met Gly 
225                 230                 235                 240 


Pro Ser Leu Leu Leu Pro Ser Val Thr Pro Thr Thr Val Thr Pro Gly 
                245                 250                 255     


Asp Gln Asp Ser Thr Ser Gln Glu Ala Glu Ala Thr Val Leu Pro Ala 
            260                 265                 270         


Ala Gly Leu Gly Val Glu Phe Glu Ala Pro Gln Glu Ala Ser Glu Glu 
        275                 280                 285             


Ala Thr Ala Gly Ala Ala Gly Leu Ser Gly Gln His Glu Glu Val Pro 
    290                 295                 300                 


Ala Leu Pro Ser Phe Pro Gln Thr Thr Ala Pro Ser Gly Ala Glu His 
305                 310                 315                 320 


Pro Asp Glu Asp Pro Leu Gly Ser Arg Thr Ser Ala Ser Ser Pro Leu 
                325                 330                 335     


Ala Pro Gly Asp Met Glu Leu Thr Pro Ser Ser Ala Thr Leu Gly Gln 
            340                 345                 350         


Glu Asp Leu Asn Gln Gln Leu Leu Glu Gly Gln Ala Ala Glu Ala Gln 
        355                 360                 365             


Ser Arg Ile Pro Trp Asp Ser Thr Gln Val Ile Cys Lys Asp Trp Ser 
    370                 375                 380                 


Asn Leu Ala Gly Lys Asn Tyr Ile Ile Leu Asn Met Thr Glu Asn Ile 
385                 390                 395                 400 


Asp Cys Glu Val Phe Arg Gln His Arg Gly Pro Gln Leu Leu Ala Leu 
                405                 410                 415     


Val Glu Glu Val Leu Pro Arg His Gly Ser Gly His His Gly Ala Trp 
            420                 425                 430         


His Ile Ser Leu Ser Lys Pro Ser Glu Lys Glu Gln His Leu Leu Met 
        435                 440                 445             


Thr Leu Val Gly Glu Gln Gly Val Val Pro Thr Gln Asp Val Leu Ser 
    450                 455                 460                 


Met Leu Gly Asp Ile Arg Arg Ser Leu Glu Glu Ile Gly Ile Gln Asn 
465                 470                 475                 480 


Tyr Ser Thr Thr Ser Ser Cys Gln Ala Arg Ala Ser Gln Val Arg Ser 
                485                 490                 495     


Asp Tyr Gly Thr Leu Phe Val Val Leu Val Val Ile Gly Ala Ile Cys 
            500                 505                 510         


Ile Ile Ile Ile Ala Leu Gly Leu Leu Tyr Asn Cys Trp Gln Arg Arg 
        515                 520                 525             


Leu Pro Lys Leu Lys His Val Ser His Gly Glu Glu Leu Arg Phe Val 
    530                 535                 540                 


Glu Asn Gly Cys His Asp Asn Pro Thr Leu Asp Val Ala Ser Asp Ser 
545                 550                 555                 560 


Gln Ser Glu Met Gln Glu Lys His Pro Ser Leu Asn Gly Gly Gly Ala 
                565                 570                 575     


Leu Asn Gly Pro Gly Ser Trp Gly Ala Leu Met Gly Gly Lys Arg Asp 
            580                 585                 590         


Pro Glu Asp Ser Asp Val Phe Glu Glu Asp Thr His Leu 
        595                 600                 605 


<210>  4119
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  4119

Met Val Lys Leu Gly Cys Ser Phe Ser Gly Lys Pro Gly Lys Asp Pro 
1               5                   10                  15      


Gly Asp Gln Asp Gly Ala Ala Met Asp Ser Val Pro Leu Ile Ser Pro 
            20                  25                  30          


Leu Asp Ile Ser Gln Leu Gln Pro Pro Leu Pro Asp Gln Val Val Ile 
        35                  40                  45              


Lys Thr Gln Thr Glu Tyr Gln Leu Ser Ser Pro Asp Gln Gln Asn Phe 
    50                  55                  60                  


Pro Asp Leu Glu Gly Gln Arg Leu Asn Cys Ser His Pro Glu Glu Gly 
65                  70                  75                  80  


Arg Arg Leu Pro Thr Ala Arg Met Ile Ala Phe Ala Met Ala Leu Leu 
                85                  90                  95      


Gly Cys Val Leu Ile Met Tyr Lys Ala Ile Trp Tyr Asp Gln Phe Thr 
            100                 105                 110         


Cys Pro Asp Gly Phe Leu Leu Arg His Lys Ile Cys Thr Pro Leu Thr 
        115                 120                 125             


Leu Glu Met Tyr Tyr Thr Glu Met Asp Pro Glu Arg His Arg Ser Ile 
    130                 135                 140                 


Leu Ala Ala Ile Gly Ala Tyr Pro Leu Ser Arg Lys His Gly Thr Glu 
145                 150                 155                 160 


Thr Pro Ala Ala Trp Gly Asp Gly Tyr Arg Ala Ala Lys Glu Glu Arg 
                165                 170                 175     


Lys Gly Pro Thr Gln Ala Gly Ala Ala Ala Ala Ala Thr Glu Pro Pro 
            180                 185                 190         


Gly Lys Pro Ser Ala Lys Ala Glu Lys Glu Ala Ala Arg Lys Ala Ala 
        195                 200                 205             


Gly Ser Ala Ala Pro Pro Pro Ala Gln 
    210                 215         


<210>  4120
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  4120

Met Asp Asn Val Leu Pro Val Asp Ser Asp Leu Ser Pro Asn Ile Ser 
1               5                   10                  15      


Thr Asn Thr Ser Glu Pro Asn Gln Phe Val Gln Pro Ala Trp Gln Ile 
            20                  25                  30          


Val Leu Trp Ala Ala Ala Tyr Thr Val Ile Val Val Thr Ser Val Val 
        35                  40                  45              


Gly Asn Val Val Val Met Trp Ile Ile Leu Ala His Lys Arg Met Arg 
    50                  55                  60                  


Thr Val Thr Asn Tyr Phe Leu Val Asn Leu Ala Phe Ala Glu Ala Ser 
65                  70                  75                  80  


Met Ala Ala Phe Asn Thr Val Val Asn Phe Thr Tyr Ala Val His Asn 
                85                  90                  95      


Glu Trp Tyr Tyr Gly Leu Phe Tyr Cys Lys Phe His Asn Phe Phe Pro 
            100                 105                 110         


Ile Ala Ala Val Phe Ala Ser Ile Tyr Ser Met Thr Ala Val Ala Phe 
        115                 120                 125             


Asp Arg Tyr Met Ala Ile Ile His Pro Leu Gln Pro Arg Leu Ser Ala 
    130                 135                 140                 


Thr Ala Thr Lys Val Val Ile Cys Val Ile Trp Val Leu Ala Leu Leu 
145                 150                 155                 160 


Leu Ala Phe Pro Gln Gly Tyr Tyr Ser Thr Thr Glu Thr Met Pro Ser 
                165                 170                 175     


Arg Val Val Cys Met Ile Glu Trp Pro Glu His Pro Asn Lys Ile Tyr 
            180                 185                 190         


Glu Lys Val Tyr His Ile Cys Val Thr Val Leu Ile Tyr Phe Leu Pro 
        195                 200                 205             


Leu Leu Val Ile Gly Tyr Ala Tyr Thr Val Val Gly Ile Thr Leu Trp 
    210                 215                 220                 


Ala Ser Glu Ile Pro Gly Asp Ser Ser Asp Arg Tyr His Glu Gln Val 
225                 230                 235                 240 


Ser Ala Lys Arg Lys Val Val Lys Met Met Ile Val Val Val Cys Thr 
                245                 250                 255     


Phe Ala Ile Cys Trp Leu Pro Phe His Ile Phe Phe Leu Leu Pro Tyr 
            260                 265                 270         


Ile Asn Pro Asp Leu Tyr Leu Lys Lys Phe Ile Gln Gln Val Tyr Leu 
        275                 280                 285             


Ala Ile Met Trp Leu Ala Met Ser Ser Thr Met Tyr Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Cys Cys Leu Asn Asp Arg 
305                 310     


<210>  4121
<211>  617
<212>  PRT
<213>  Homo sapiens

<400>  4121

Met Arg Pro Pro Gln Cys Leu Leu His Thr Pro Ser Leu Ala Ser Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Trp Leu Leu Gly Gly Gly Val Gly Ala Glu 
            20                  25                  30          


Gly Arg Glu Asp Ala Glu Leu Leu Val Thr Val Arg Gly Gly Arg Leu 
        35                  40                  45              


Arg Gly Ile Arg Leu Lys Thr Pro Gly Gly Pro Val Ser Ala Phe Leu 
    50                  55                  60                  


Gly Ile Pro Phe Ala Glu Pro Pro Met Gly Pro Arg Arg Phe Leu Pro 
65                  70                  75                  80  


Pro Glu Pro Lys Gln Pro Trp Ser Gly Val Val Asp Ala Thr Thr Phe 
                85                  90                  95      


Gln Ser Val Cys Tyr Gln Tyr Val Asp Thr Leu Tyr Pro Gly Phe Glu 
            100                 105                 110         


Gly Thr Glu Met Trp Asn Pro Asn Arg Glu Leu Ser Glu Asp Cys Leu 
        115                 120                 125             


Tyr Leu Asn Val Trp Thr Pro Tyr Pro Arg Pro Thr Ser Pro Thr Pro 
    130                 135                 140                 


Val Leu Val Trp Ile Tyr Gly Gly Gly Phe Tyr Ser Gly Ala Ser Ser 
145                 150                 155                 160 


Leu Asp Val Tyr Asp Gly Arg Phe Leu Val Gln Ala Glu Arg Thr Val 
                165                 170                 175     


Leu Val Ser Met Asn Tyr Arg Val Gly Ala Phe Gly Phe Leu Ala Leu 
            180                 185                 190         


Pro Gly Ser Arg Glu Ala Pro Gly Asn Val Gly Leu Leu Asp Gln Arg 
        195                 200                 205             


Leu Ala Leu Gln Trp Val Gln Glu Asn Val Ala Ala Phe Gly Gly Asp 
    210                 215                 220                 


Pro Thr Ser Val Thr Leu Phe Gly Glu Ser Ala Gly Ala Ala Ser Val 
225                 230                 235                 240 


Gly Met His Leu Leu Ser Pro Pro Ser Arg Gly Leu Phe His Arg Ala 
                245                 250                 255     


Val Leu Gln Ser Gly Ala Pro Asn Gly Pro Trp Ala Thr Val Gly Met 
            260                 265                 270         


Gly Glu Ala Arg Arg Arg Ala Thr Gln Leu Ala His Leu Val Gly Cys 
        275                 280                 285             


Pro Pro Gly Gly Thr Gly Gly Asn Asp Thr Glu Leu Val Ala Cys Leu 
    290                 295                 300                 


Arg Thr Arg Pro Ala Gln Val Leu Val Asn His Glu Trp His Val Leu 
305                 310                 315                 320 


Pro Gln Glu Ser Val Phe Arg Phe Ser Phe Val Pro Val Val Asp Gly 
                325                 330                 335     


Asp Phe Leu Ser Asp Thr Pro Glu Ala Leu Ile Asn Ala Gly Asp Phe 
            340                 345                 350         


His Gly Leu Gln Val Leu Val Gly Val Val Lys Asp Glu Gly Ser Tyr 
        355                 360                 365             


Phe Leu Val Tyr Gly Ala Pro Gly Phe Ser Lys Asp Asn Glu Ser Leu 
    370                 375                 380                 


Ile Ser Arg Ala Glu Phe Leu Ala Gly Val Arg Val Gly Val Pro Gln 
385                 390                 395                 400 


Val Ser Asp Leu Ala Ala Glu Ala Val Val Leu His Tyr Thr Asp Trp 
                405                 410                 415     


Leu His Pro Glu Asp Pro Ala Arg Leu Arg Glu Ala Leu Ser Asp Val 
            420                 425                 430         


Val Gly Asp His Asn Val Val Cys Pro Val Ala Gln Leu Ala Gly Arg 
        435                 440                 445             


Leu Ala Ala Gln Gly Ala Arg Val Tyr Ala Tyr Val Phe Glu His Arg 
    450                 455                 460                 


Ala Ser Thr Leu Ser Trp Pro Leu Trp Met Gly Val Pro His Gly Tyr 
465                 470                 475                 480 


Glu Ile Glu Phe Ile Phe Gly Ile Pro Leu Asp Pro Ser Arg Asn Tyr 
                485                 490                 495     


Thr Ala Glu Glu Lys Ile Phe Ala Gln Arg Leu Met Arg Tyr Trp Ala 
            500                 505                 510         


Asn Phe Ala Arg Thr Gly Asp Pro Asn Glu Pro Arg Asp Pro Lys Ala 
        515                 520                 525             


Pro Gln Trp Pro Pro Tyr Thr Ala Gly Ala Gln Gln Tyr Val Ser Leu 
    530                 535                 540                 


Asp Leu Arg Pro Leu Glu Val Arg Arg Gly Leu Arg Ala Gln Ala Cys 
545                 550                 555                 560 


Ala Phe Trp Asn Arg Phe Leu Pro Lys Leu Leu Ser Ala Thr Ala Ser 
                565                 570                 575     


Glu Ala Pro Ser Thr Cys Pro Gly Phe Thr His Gly Glu Ala Ala Pro 
            580                 585                 590         


Arg Pro Gly Leu Pro Leu Pro Leu Leu Leu Leu His Gln Leu Leu Leu 
        595                 600                 605             


Leu Phe Leu Ser His Leu Arg Arg Leu 
    610                 615         


<210>  4122
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  4122

Met Glu Leu Asp Arg Ala Val Gly Val Leu Gly Ala Ala Thr Leu Leu 
1               5                   10                  15      


Leu Ser Phe Leu Gly Met Ala Trp Ala Leu Gln Ala Ala Asp Thr Cys 
            20                  25                  30          


Pro Gly Glu Arg Gly Pro Pro Gly Pro Pro Gly Lys Ala Gly Pro Pro 
        35                  40                  45              


Gly Pro Asn Gly Ala Pro Gly Glu Pro Gln Pro Cys Leu Thr Gly Pro 
    50                  55                  60                  


Arg Thr Cys Lys Asp Leu Leu Asp Arg Gly His Phe Leu Ser Gly Trp 
65                  70                  75                  80  


His Thr Ile Tyr Leu Pro Asp Cys Arg Pro Leu Thr Val Leu Cys Asp 
                85                  90                  95      


Met Asp Thr Asp Gly Gly Gly Trp Thr Val Phe Gln Arg Arg Val Asp 
            100                 105                 110         


Gly Ser Val Asp Phe Tyr Arg Asp Trp Ala Thr Tyr Lys Gln Gly Phe 
        115                 120                 125             


Gly Ser Arg Leu Gly Glu Phe Trp Leu Gly Asn Asp Asn Ile His Ala 
    130                 135                 140                 


Leu Thr Ala Gln Gly Thr Ser Glu Leu Arg Val Asp Leu Val Asp Phe 
145                 150                 155                 160 


Glu Asp Asn Tyr Gln Phe Ala Lys Tyr Arg Ser Phe Lys Val Ala Asp 
                165                 170                 175     


Glu Ala Glu Lys Tyr Asn Leu Val Leu Gly Ala Phe Val Glu Gly Ser 
            180                 185                 190         


Ala Gly Asp Ser Leu Thr Phe His Asn Asn Gln Ser Phe Ser Thr Lys 
        195                 200                 205             


Asp Gln Asp Asn Asp Leu Asn Thr Gly Asn Cys Ala Val Met Phe Gln 
    210                 215                 220                 


Gly Ala Trp Trp Tyr Lys Asn Cys His Val Ser Asn Leu Asn Gly Arg 
225                 230                 235                 240 


Tyr Leu Arg Gly Thr His Gly Ser Phe Ala Asn Gly Ile Asn Trp Lys 
                245                 250                 255     


Ser Gly Lys Gly Tyr Asn Tyr Ser Tyr Lys Val Ser Glu Met Lys Val 
            260                 265                 270         


Arg Pro Ala 
        275 


<210>  4123
<211>  1385
<212>  PRT
<213>  Homo sapiens

<400>  4123

Met Gln Asp Tyr Asn Lys Asp Asp Met Ser Tyr Arg Arg Ile Ser Ala 
1               5                   10                  15      


Val Glu Pro Lys Thr Ala Leu Pro Phe Asn Arg Phe Leu Pro Asn Lys 
            20                  25                  30          


Ser Arg Gln Pro Ser Tyr Val Pro Ala Pro Leu Arg Lys Lys Lys Pro 
        35                  40                  45              


Asp Lys His Glu Asp Asn Arg Arg Ser Trp Ala Ser Pro Val Tyr Thr 
    50                  55                  60                  


Glu Ala Asp Gly Thr Phe Ser Ser Asn Gln Arg Arg Ile Trp Gly Thr 
65                  70                  75                  80  


Asn Val Glu Asn Trp Pro Thr Val Gln Gly Thr Ser Lys Ser Ser Cys 
                85                  90                  95      


Tyr Leu Glu Glu Glu Lys Ala Lys Thr Arg Ser Ile Pro Asn Ile Val 
            100                 105                 110         


Lys Asp Asp Leu Tyr Val Arg Lys Leu Ser Pro Val Met Pro Asn Pro 
        115                 120                 125             


Gly Asn Ala Phe Asp Gln Phe Leu Pro Lys Cys Trp Thr Pro Glu Asp 
    130                 135                 140                 


Val Asn Trp Lys Arg Ile Lys Arg Glu Thr Tyr Lys Pro Trp Tyr Lys 
145                 150                 155                 160 


Glu Phe Gln Gly Phe Ser Gln Phe Leu Leu Leu Gln Ala Leu Gln Thr 
                165                 170                 175     


Tyr Ser Asp Asp Ile Leu Ser Ser Glu Thr His Thr Lys Ile Asp Pro 
            180                 185                 190         


Thr Ser Gly Pro Arg Leu Ile Thr Arg Arg Lys Asn Leu Ser Tyr Ala 
        195                 200                 205             


Pro Gly Tyr Arg Arg Asp Asp Leu Glu Met Ala Ala Leu Asp Pro Asp 
    210                 215                 220                 


Leu Glu Asn Asp Asp Phe Phe Val Arg Lys Thr Gly Ala Phe His Ala 
225                 230                 235                 240 


Asn Pro Tyr Val Leu Arg Ala Phe Glu Asp Phe Arg Lys Phe Ser Glu 
                245                 250                 255     


Gln Asp Asp Ser Val Glu Arg Asp Ile Ile Leu Gln Cys Arg Glu Gly 
            260                 265                 270         


Glu Leu Val Leu Pro Asp Leu Glu Lys Asp Asp Met Ile Val Arg Arg 
        275                 280                 285             


Ile Pro Ala Gln Lys Lys Glu Val Pro Leu Ser Gly Ala Pro Asp Arg 
    290                 295                 300                 


Tyr His Pro Val Pro Phe Pro Glu Pro Trp Thr Leu Pro Pro Glu Ile 
305                 310                 315                 320 


Gln Ala Lys Phe Leu Cys Val Leu Glu Arg Thr Cys Pro Ser Lys Glu 
                325                 330                 335     


Lys Ser Asn Ser Cys Arg Ile Leu Val Pro Ser Tyr Arg Gln Lys Lys 
            340                 345                 350         


Asp Asp Met Leu Thr Arg Lys Ile Gln Ser Trp Lys Leu Gly Thr Thr 
        355                 360                 365             


Val Pro Pro Ile Ser Phe Thr Pro Gly Pro Cys Ser Glu Ala Asp Leu 
    370                 375                 380                 


Lys Arg Trp Glu Ala Ile Arg Glu Ala Ser Arg Leu Arg His Lys Lys 
385                 390                 395                 400 


Arg Leu Met Val Glu Arg Leu Phe Gln Lys Ile Tyr Gly Glu Asn Gly 
                405                 410                 415     


Ser Lys Ser Met Ser Asp Val Ser Ala Glu Asp Val Gln Asn Leu Arg 
            420                 425                 430         


Gln Leu Arg Tyr Glu Glu Met Gln Lys Ile Lys Ser Gln Leu Lys Glu 
        435                 440                 445             


Gln Asp Gln Lys Trp Gln Asp Asp Leu Ala Lys Trp Lys Asp Arg Arg 
    450                 455                 460                 


Lys Ser Tyr Thr Ser Asp Leu Gln Lys Lys Lys Glu Glu Arg Glu Glu 
465                 470                 475                 480 


Ile Glu Lys Gln Ala Leu Glu Lys Ser Lys Arg Ser Ser Lys Thr Phe 
                485                 490                 495     


Lys Glu Met Leu Gln Asp Arg Glu Ser Gln Asn Gln Lys Ser Thr Val 
            500                 505                 510         


Pro Ser Arg Arg Arg Met Tyr Ser Phe Asp Asp Val Leu Glu Glu Gly 
        515                 520                 525             


Lys Arg Pro Pro Thr Met Thr Val Ser Glu Ala Ser Tyr Gln Ser Glu 
    530                 535                 540                 


Arg Val Glu Glu Lys Gly Ala Thr Tyr Pro Ser Glu Ile Pro Lys Glu 
545                 550                 555                 560 


Asp Ser Thr Thr Phe Ala Lys Arg Glu Asp Arg Val Thr Thr Glu Ile 
                565                 570                 575     


Gln Leu Pro Ser Gln Ser Pro Val Glu Glu Gln Ser Pro Ala Ser Leu 
            580                 585                 590         


Ser Ser Leu Arg Ser Arg Ser Thr Gln Met Glu Ser Thr Arg Val Ser 
        595                 600                 605             


Ala Ser Leu Pro Arg Ser Tyr Arg Lys Thr Asp Thr Val Arg Leu Thr 
    610                 615                 620                 


Ser Val Val Thr Pro Arg Pro Phe Gly Ser Gln Thr Arg Gly Ile Ser 
625                 630                 635                 640 


Ser Leu Pro Arg Ser Tyr Thr Met Asp Asp Ala Trp Lys Tyr Asn Gly 
                645                 650                 655     


Asp Val Glu Asp Ile Lys Arg Thr Pro Asn Asn Val Val Ser Thr Pro 
            660                 665                 670         


Ala Pro Ser Pro Asp Ala Ser Gln Leu Ala Ser Ser Leu Ser Ser Gln 
        675                 680                 685             


Lys Glu Val Ala Ala Thr Glu Glu Asp Val Thr Arg Leu Pro Ser Pro 
    690                 695                 700                 


Thr Ser Pro Phe Ser Ser Leu Ser Gln Asp Gln Ala Ala Thr Ser Lys 
705                 710                 715                 720 


Ala Thr Leu Ser Ser Thr Ser Gly Leu Asp Leu Met Ser Glu Ser Gly 
                725                 730                 735     


Glu Gly Glu Ile Ser Pro Gln Arg Glu Val Ser Arg Ser Gln Asp Gln 
            740                 745                 750         


Phe Ser Asp Met Arg Ile Ser Ile Asn Gln Thr Pro Gly Lys Ser Leu 
        755                 760                 765             


Asp Phe Gly Phe Thr Ile Lys Trp Asp Ile Pro Gly Ile Phe Val Ala 
    770                 775                 780                 


Ser Val Glu Ala Gly Ser Pro Ala Glu Phe Ser Gln Leu Gln Val Asp 
785                 790                 795                 800 


Asp Glu Ile Ile Ala Ile Asn Asn Thr Lys Phe Ser Tyr Asn Asp Ser 
                805                 810                 815     


Lys Glu Trp Glu Glu Ala Met Ala Lys Ala Gln Glu Thr Gly His Leu 
            820                 825                 830         


Val Met Asp Val Arg Arg Tyr Gly Lys Ala Gly Ser Pro Glu Thr Lys 
        835                 840                 845             


Trp Ile Asp Ala Thr Ser Gly Ile Tyr Asn Ser Glu Lys Ser Ser Asn 
    850                 855                 860                 


Leu Ser Val Thr Thr Asp Phe Ser Glu Ser Leu Gln Ser Ser Asn Ile 
865                 870                 875                 880 


Glu Ser Lys Glu Ile Asn Gly Ile His Asp Glu Ser Asn Ala Phe Glu 
                885                 890                 895     


Ser Lys Ala Ser Glu Ser Ile Ser Leu Lys Asn Leu Lys Arg Arg Ser 
            900                 905                 910         


Gln Phe Phe Glu Gln Gly Ser Ser Asp Ser Val Val Pro Asp Leu Pro 
        915                 920                 925             


Val Pro Thr Ile Ser Ala Pro Ser Arg Trp Val Trp Asp Gln Glu Glu 
    930                 935                 940                 


Glu Arg Lys Arg Gln Glu Arg Trp Gln Lys Glu Gln Asp Arg Leu Leu 
945                 950                 955                 960 


Gln Glu Lys Tyr Gln Arg Glu Gln Glu Lys Leu Arg Glu Glu Trp Gln 
                965                 970                 975     


Arg Ala Lys Gln Glu Ala Glu Arg Glu Asn Ser Lys Tyr Leu Asp Glu 
            980                 985                 990         


Glu Leu Met Val Leu Ser Ser Asn  Ser Met Ser Leu Thr  Thr Arg Glu 
        995                 1000                 1005             


Pro Ser  Leu Ala Thr Trp Glu  Ala Thr Trp Ser Glu  Gly Ser Lys 
    1010                 1015                 1020             


Ser Ser  Asp Arg Glu Gly Thr  Arg Ala Gly Glu Glu  Glu Arg Arg 
    1025                 1030                 1035             


Gln Pro  Gln Glu Glu Val Val  His Glu Asp Gln Gly  Lys Lys Pro 
    1040                 1045                 1050             


Gln Asp  Gln Leu Val Ile Glu  Arg Glu Arg Lys Trp  Glu Gln Gln 
    1055                 1060                 1065             


Leu Gln  Glu Glu Gln Glu Gln  Lys Arg Leu Gln Ala  Glu Ala Glu 
    1070                 1075                 1080             


Glu Gln  Lys Arg Pro Ala Glu  Glu Gln Lys Arg Gln  Ala Glu Ile 
    1085                 1090                 1095             


Glu Arg  Glu Thr Ser Val Arg  Ile Tyr Gln Tyr Arg  Arg Pro Val 
    1100                 1105                 1110             


Asp Ser  Tyr Asp Ile Pro Lys  Thr Glu Glu Ala Ser  Ser Gly Phe 
    1115                 1120                 1125             


Leu Pro  Gly Asp Arg Asn Lys  Ser Arg Ser Thr Thr  Glu Leu Asp 
    1130                 1135                 1140             


Asp Tyr  Ser Thr Asn Lys Asn  Gly Asn Asn Lys Tyr  Leu Asp Gln 
    1145                 1150                 1155             


Ile Gly  Asn Met Thr Ser Ser  Gln Arg Arg Ser Lys  Lys Glu Gln 
    1160                 1165                 1170             


Val Pro  Ser Gly Ala Glu Leu  Glu Arg Gln Gln Ile  Leu Gln Glu 
    1175                 1180                 1185             


Met Arg  Lys Arg Thr Pro Leu  His Asn Asp Asn Ser  Trp Ile Arg 
    1190                 1195                 1200             


Gln Arg  Ser Ala Ser Val Asn  Lys Glu Pro Val Ser  Leu Pro Gly 
    1205                 1210                 1215             


Ile Met  Arg Arg Gly Glu Ser  Leu Asp Asn Leu Asp  Ser Pro Arg 
    1220                 1225                 1230             


Ser Asn  Ser Trp Arg Gln Pro  Pro Trp Leu Asn Gln  Pro Thr Gly 
    1235                 1240                 1245             


Phe Tyr  Ala Ser Ser Ser Val  Gln Asp Phe Ser Arg  Pro Pro Pro 
    1250                 1255                 1260             


Gln Leu  Val Ser Thr Ser Asn  Arg Ala Tyr Met Arg  Asn Pro Ser 
    1265                 1270                 1275             


Ser Ser  Val Pro Pro Pro Ser  Ala Gly Ser Val Lys  Thr Ser Thr 
    1280                 1285                 1290             


Thr Gly  Val Ala Thr Thr Gln  Ser Pro Thr Pro Arg  Ser His Ser 
    1295                 1300                 1305             


Pro Ser  Ala Ser Gln Ser Gly  Ser Gln Leu Arg Asn  Ser Val Leu 
    1310                 1315                 1320             


Pro Val  Ser Val Thr Ser Glu  Ala Leu Pro Gln Glu  Leu Lys Ser 
    1325                 1330                 1335             


Gly Ser  Glu Thr Thr Asn Cys  Thr Ala Thr Thr Ala  Ile Ser Asp 
    1340                 1345                 1350             


Ser Asn  Leu Asp Gly Gln Pro  Pro Cys Asp Val Ser  Leu His Thr 
    1355                 1360                 1365             


Lys Ala  Leu Leu Gln Ile Glu  Glu Glu Val Val Ala  Ala His Val 
    1370                 1375                 1380             


Asp Leu  
    1385 


<210>  4124
<211>  820
<212>  PRT
<213>  Homo sapiens

<400>  4124

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          


Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly 
        35                  40                  45              


Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  


Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg 
65                  70                  75                  80  


Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser 
                85                  90                  95      


Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr 
            100                 105                 110         


Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
        115                 120                 125             


Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
    130                 135                 140                 


Lys Pro Asn Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys Met Glu 
145                 150                 155                 160 


Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe Lys Cys 
                165                 170                 175     


Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys Asn Gly 
            180                 185                 190         


Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val Arg Tyr 
        195                 200                 205             


Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp Lys Gly 
    210                 215                 220                 


Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr 
225                 230                 235                 240 


Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
                245                 250                 255     


Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn Val Glu 
            260                 265                 270         


Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln Trp Leu 
        275                 280                 285             


Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn Leu Pro 
    290                 295                 300                 


Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp Lys Glu 
305                 310                 315                 320 


Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala Gly Glu 
                325                 330                 335     


Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His Ser Ala 
            340                 345                 350         


Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val Met Thr 
        355                 360                 365             


Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala Phe Leu 
    370                 375                 380                 


Ile Ser Cys Met Val Gly Ser Val Ile Val Tyr Lys Met Lys Ser Gly 
385                 390                 395                 400 


Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys Leu Ala 
                405                 410                 415     


Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Asp Ser Ser 
            420                 425                 430         


Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg Leu Ser 
        435                 440                 445             


Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro 
    450                 455                 460                 


Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu Gly Lys 
465                 470                 475                 480 


Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu Ala Ile 
                485                 490                 495     


Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala Val Lys 
            500                 505                 510         


Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Ile Ser 
        515                 520                 525             


Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn 
    530                 535                 540                 


Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu 
545                 550                 555                 560 


Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg Arg Pro 
                565                 570                 575     


Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu Glu Gln 
            580                 585                 590         


Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly 
        595                 600                 605             


Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu Ala Ala 
    610                 615                 620                 


Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe 
625                 630                 635                 640 


Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys Thr Thr 
                645                 650                 655     


Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp 
            660                 665                 670         


Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu 
        675                 680                 685             


Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val Pro Val 
    690                 695                 700                 


Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro 
705                 710                 715                 720 


Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp His 
                725                 730                 735     


Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu 
            740                 745                 750         


Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp Leu Ser 
        755                 760                 765             


Met Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg Ser Ser 
    770                 775                 780                 


Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro Leu Pro 
785                 790                 795                 800 


Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln Leu Ala Asn Gly Gly 
                805                 810                 815     


Leu Lys Arg Arg 
            820 


<210>  4125
<211>  389
<212>  PRT
<213>  Homo sapiens

<400>  4125

Met Glu Asp Ser Pro Thr Met Val Arg Val Asp Ser Pro Thr Met Val 
1               5                   10                  15      


Arg Gly Glu Asn Gln Val Ser Pro Cys Gln Gly Arg Arg Cys Phe Pro 
            20                  25                  30          


Lys Ala Leu Gly Tyr Val Thr Gly Asp Met Lys Glu Leu Ala Asn Gln 
        35                  40                  45              


Leu Lys Asp Lys Pro Val Val Leu Gln Phe Ile Asp Trp Ile Leu Arg 
    50                  55                  60                  


Gly Ile Ser Gln Val Val Phe Val Asn Asn Pro Val Ser Gly Ile Leu 
65                  70                  75                  80  


Ile Leu Val Gly Leu Leu Val Gln Asn Pro Trp Trp Ala Leu Thr Gly 
                85                  90                  95      


Trp Leu Gly Thr Val Val Ser Thr Leu Met Ala Leu Leu Leu Ser Gln 
            100                 105                 110         


Asp Arg Ser Leu Ile Ala Ser Gly Leu Tyr Gly Tyr Asn Ala Thr Leu 
        115                 120                 125             


Val Gly Val Leu Met Ala Val Phe Ser Asp Lys Gly Asp Tyr Phe Trp 
    130                 135                 140                 


Trp Leu Leu Leu Pro Val Cys Ala Met Ser Met Thr Cys Pro Ile Phe 
145                 150                 155                 160 


Ser Ser Ala Leu Asn Ser Met Leu Ser Lys Trp Asp Leu Pro Val Phe 
                165                 170                 175     


Thr Leu Pro Phe Asn Met Ala Leu Ser Met Tyr Leu Ser Ala Thr Gly 
            180                 185                 190         


His Tyr Asn Pro Phe Phe Pro Ala Lys Leu Val Ile Pro Ile Thr Thr 
        195                 200                 205             


Ala Pro Asn Ile Ser Trp Ser Asp Leu Ser Ala Leu Glu Leu Leu Lys 
    210                 215                 220                 


Ser Ile Pro Val Gly Val Gly Gln Ile Tyr Gly Cys Asp Asn Pro Trp 
225                 230                 235                 240 


Thr Gly Gly Ile Phe Leu Gly Ala Ile Leu Leu Ser Ser Pro Leu Met 
                245                 250                 255     


Cys Leu His Ala Ala Ile Gly Ser Leu Leu Gly Ile Ala Ala Gly Leu 
            260                 265                 270         


Ser Leu Ser Ala Pro Phe Glu Asp Ile Tyr Phe Gly Leu Trp Gly Phe 
        275                 280                 285             


Asn Ser Ser Leu Ala Cys Ile Ala Met Gly Gly Met Phe Met Ala Leu 
    290                 295                 300                 


Thr Trp Gln Thr His Leu Leu Ala Leu Gly Cys Ala Leu Phe Thr Ala 
305                 310                 315                 320 


Tyr Leu Gly Val Gly Met Ala Asn Phe Met Ala Glu Val Gly Leu Pro 
                325                 330                 335     


Ala Cys Thr Trp Pro Phe Cys Leu Ala Thr Leu Leu Phe Leu Ile Met 
            340                 345                 350         


Thr Thr Lys Asn Ser Asn Ile Tyr Lys Met Pro Leu Ser Lys Val Thr 
        355                 360                 365             


Tyr Pro Glu Glu Asn Arg Ile Phe Tyr Leu Gln Ala Lys Lys Arg Met 
    370                 375                 380                 


Val Glu Ser Pro Leu 
385                 


<210>  4126
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  4126

Met Ser Leu Met Val Val Ser Met Val Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro His Glu Gly Val His Arg Lys Pro Ser Leu Leu 
            20                  25                  30          


Ala His Pro Gly Pro Leu Val Lys Ser Glu Glu Thr Val Ile Leu Gln 
        35                  40                  45              


Cys Trp Ser Asp Val Arg Phe Gln His Phe Leu Leu His Arg Glu Gly 
    50                  55                  60                  


Lys Phe Lys Asp Thr Leu His Leu Ile Gly Glu His His Asp Gly Val 
65                  70                  75                  80  


Ser Lys Ala Asn Phe Ser Ile Gly Pro Met Met Gln Asp Leu Ala Gly 
                85                  90                  95      


Thr Tyr Arg Cys Tyr Gly Ser Val Thr His Ser Pro Tyr Gln Leu Ser 
            100                 105                 110         


Ala Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys 
        115                 120                 125             


Pro Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Leu Ala Gly Glu Ser 
    130                 135                 140                 


Val Thr Leu Ser Cys Ser Ser Arg Ser Ser Tyr Asp Met Tyr His Leu 
145                 150                 155                 160 


Ser Arg Glu Gly Glu Ala His Glu Arg Arg Phe Ser Ala Gly Pro Lys 
                165                 170                 175     


Val Asn Gly Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His 
            180                 185                 190         


Gly Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Asp Ser Pro Tyr Glu 
        195                 200                 205             


Trp Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro 
    210                 215                 220                 


Ser Asn Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Glu Thr Gly Asn 
225                 230                 235                 240 


Pro Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Ile Ile Leu 
                245                 250                 255     


Phe Ile Leu Leu Leu Phe Phe Leu Leu His Arg Trp Cys Cys Asn Lys 
            260                 265                 270         


Lys Asn Ala Val Val Met Asp Gln Glu Pro Ala Gly Asn Arg Thr Val 
        275                 280                 285             


Asn Arg Glu Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala 
    290                 295                 300                 


Gln Leu Asn His Cys Val Phe Thr Gln Arg Lys Ile Thr Arg Pro Ser 
305                 310                 315                 320 


Gln Arg Pro Lys Thr Pro Pro Thr Asp Ile Ile Val Tyr Thr Glu Leu 
                325                 330                 335     


Pro Asn Ala Glu Pro 
            340     


<210>  4127
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  4127

Met Arg Asn Cys Lys Met Ala Arg Val Ala Ser Val Leu Gly Leu Val 
1               5                   10                  15      


Met Leu Ser Val Ala Leu Leu Ile Leu Ser Leu Ile Ser Tyr Val Ser 
            20                  25                  30          


Leu Lys Lys Glu Asn Ile Phe Thr Thr Pro Lys Tyr Ala Ser Pro Gly 
        35                  40                  45              


Ala Pro Arg Met Tyr Met Phe His Ala Gly Phe Arg Ser Gln Phe Ala 
    50                  55                  60                  


Leu Lys Phe Leu Asp Pro Ser Phe Val Pro Ile Thr Asn Ser Leu Thr 
65                  70                  75                  80  


Gln Glu Leu Gln Glu Lys Pro Ser Lys Trp Lys Phe Asn Arg Thr Ala 
                85                  90                  95      


Phe Leu His Gln Arg Gln Glu Ile Leu Gln His Val Asp Val Ile Lys 
            100                 105                 110         


Asn Phe Ser Leu Thr Lys Asn Ser Val Arg Ile Gly Gln Leu Met His 
        115                 120                 125             


Tyr Asp Tyr Ser Ser His Lys Tyr Val Phe Ser Ile Ser Asn Asn Phe 
    130                 135                 140                 


Arg Ser Leu Leu Pro Asp Val Ser Pro Ile Met Asn Lys His Tyr Asn 
145                 150                 155                 160 


Ile Cys Ala Val Val Gly Asn Ser Gly Ile Leu Thr Gly Ser Gln Cys 
                165                 170                 175     


Gly Gln Glu Ile Asp Lys Ser Asp Phe Val Phe Arg Cys Asn Phe Ala 
            180                 185                 190         


Pro Thr Glu Ala Phe Gln Arg Asp Val Gly Arg Lys Thr Asn Leu Thr 
        195                 200                 205             


Thr Phe Asn Pro Ser Ile Leu Glu Lys Tyr Tyr Asn Asn Leu Leu Thr 
    210                 215                 220                 


Ile Gln Asp Arg Asn Asn Phe Phe Leu Ser Leu Lys Lys Leu Asp Gly 
225                 230                 235                 240 


Ala Ile Leu Trp Ile Pro Ala Phe Phe Phe His Thr Ser Ala Thr Val 
                245                 250                 255     


Thr Arg Thr Leu Val Asp Phe Phe Val Glu His Arg Gly Gln Leu Lys 
            260                 265                 270         


Val Gln Leu Ala Trp Pro Gly Asn Ile Met Gln His Val Asn Arg Tyr 
        275                 280                 285             


Trp Lys Asn Lys His Leu Ser Pro Lys Arg Leu Ser Thr Gly Ile Leu 
    290                 295                 300                 


Met Tyr Thr Leu Ala Ser Ala Ile Cys Glu Glu Ile His Leu Tyr Gly 
305                 310                 315                 320 


Phe Trp Pro Phe Gly Phe Asp Pro Asn Thr Arg Glu Asp Leu Pro Tyr 
                325                 330                 335     


His Tyr Tyr Asp Lys Lys Gly Thr Lys Phe Thr Thr Lys Trp Gln Glu 
            340                 345                 350         


Ser His Gln Leu Pro Ala Glu Phe Gln Leu Leu Tyr Arg Met His Gly 
        355                 360                 365             


Glu Gly Leu Thr Lys Leu Thr Leu Ser His Cys Ala 
    370                 375                 380 


<210>  4128
<211>  519
<212>  PRT
<213>  Homo sapiens

<400>  4128

Met Ile Pro Val Ser Leu Val Val Val Val Val Gly Gly Trp Thr Val 
1               5                   10                  15      


Val Tyr Leu Thr Asp Leu Val Leu Lys Ser Ser Val Tyr Phe Lys His 
            20                  25                  30          


Ser Tyr Glu Asp Trp Leu Glu Asn Asn Gly Leu Ser Ile Ser Pro Phe 
        35                  40                  45              


His Ile Arg Trp Gln Thr Ala Val Phe Asn Arg Ala Phe Tyr Ser Trp 
    50                  55                  60                  


Gly Arg Arg Lys Ala Arg Met Leu Tyr Gln Trp Phe Asn Phe Gly Met 
65                  70                  75                  80  


Val Phe Gly Val Ile Ala Met Phe Ser Ser Phe Phe Leu Leu Gly Lys 
                85                  90                  95      


Thr Leu Met Gln Thr Leu Ala Gln Met Met Ala Asp Ser Pro Ser Ser 
            100                 105                 110         


Tyr Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
        115                 120                 125             


Ser Ser Ser Ser Ser Ser Ser Ser Leu His Asn Glu Gln Val Leu Gln 
    130                 135                 140                 


Val Val Val Pro Gly Ile Asn Leu Pro Val Asn Gln Leu Thr Tyr Phe 
145                 150                 155                 160 


Phe Thr Ala Val Leu Ile Ser Gly Val Val His Glu Ile Gly His Gly 
                165                 170                 175     


Ile Ala Ala Ile Arg Glu Gln Val Arg Phe Asn Gly Phe Gly Ile Phe 
            180                 185                 190         


Leu Phe Ile Ile Tyr Pro Gly Ala Phe Val Asp Leu Phe Thr Thr His 
        195                 200                 205             


Leu Gln Leu Ile Ser Pro Val Gln Gln Leu Arg Ile Phe Cys Ala Gly 
    210                 215                 220                 


Ile Trp His Asn Phe Val Leu Ala Leu Leu Gly Ile Leu Ala Leu Val 
225                 230                 235                 240 


Leu Leu Pro Val Ile Leu Leu Pro Phe Tyr Tyr Thr Gly Val Gly Val 
                245                 250                 255     


Leu Ile Thr Glu Val Ala Glu Asp Ser Pro Ala Ile Gly Pro Arg Gly 
            260                 265                 270         


Leu Phe Val Gly Asp Leu Val Thr His Leu Gln Asp Cys Pro Val Thr 
        275                 280                 285             


Asn Val Gln Asp Trp Asn Glu Cys Leu Asp Thr Ile Ala Tyr Glu Pro 
    290                 295                 300                 


Gln Ile Gly Tyr Cys Ile Ser Ala Ser Thr Leu Gln Gln Leu Ser Phe 
305                 310                 315                 320 


Pro Val Arg Ala Tyr Lys Arg Leu Asp Gly Ser Thr Glu Cys Cys Asn 
                325                 330                 335     


Asn His Ser Leu Thr Asp Val Cys Phe Ser Tyr Arg Asn Asn Phe Asn 
            340                 345                 350         


Lys Arg Leu His Thr Cys Leu Pro Ala Arg Lys Ala Val Glu Ala Thr 
        355                 360                 365             


Gln Val Cys Arg Thr Asn Lys Asp Cys Lys Lys Ser Ser Ser Ser Ser 
    370                 375                 380                 


Phe Cys Ile Ile Pro Ser Leu Glu Thr His Thr Arg Leu Ile Lys Val 
385                 390                 395                 400 


Lys His Pro Pro Gln Ile Asp Met Leu Tyr Val Gly His Pro Leu His 
                405                 410                 415     


Leu His Tyr Thr Val Ser Ile Thr Ser Phe Ile Pro Arg Phe Asn Phe 
            420                 425                 430         


Leu Ser Ile Asp Leu Pro Val Val Val Glu Thr Phe Val Lys Tyr Leu 
        435                 440                 445             


Ile Ser Leu Ser Gly Ala Leu Ala Ile Val Asn Ala Val Pro Cys Phe 
    450                 455                 460                 


Ala Leu Asp Gly Gln Trp Ile Leu Asn Ser Phe Leu Asp Ala Thr Leu 
465                 470                 475                 480 


Thr Ser Val Ile Gly Asp Asn Asp Val Lys Asp Leu Ile Gly Phe Phe 
                485                 490                 495     


Ile Leu Leu Gly Gly Ser Val Leu Leu Ala Ala Asn Val Thr Leu Gly 
            500                 505                 510         


Leu Trp Met Val Thr Ala Arg 
        515                 


<210>  4129
<211>  561
<212>  PRT
<213>  Homo sapiens

<400>  4129

Met Arg His Cys Ile Asn Cys Cys Ile Gln Leu Leu Pro Asp Gly Ala 
1               5                   10                  15      


His Lys Gln Gln Val Asn Cys Gln Gly Gly Pro His His Gly His Gln 
            20                  25                  30          


Ala Cys Pro Thr Cys Lys Gly Glu Asn Lys Ile Leu Phe Arg Val Asp 
        35                  40                  45              


Ser Lys Gln Met Asn Leu Leu Ala Val Leu Glu Val Arg Thr Glu Gly 
    50                  55                  60                  


Asn Glu Asn Trp Gly Gly Phe Leu Arg Phe Lys Lys Gly Lys Arg Cys 
65                  70                  75                  80  


Ser Leu Val Phe Gly Leu Ile Ile Met Thr Leu Val Met Ala Ser Tyr 
                85                  90                  95      


Ile Leu Ser Gly Ala His Gln Glu Leu Leu Ile Ser Ser Pro Phe His 
            100                 105                 110         


Tyr Gly Gly Phe Pro Ser Asn Pro Ser Leu Met Asp Ser Glu Asn Pro 
        115                 120                 125             


Ser Asp Thr Lys Glu His His His Gln Ser Ser Val Asn Asn Ile Ser 
    130                 135                 140                 


Tyr Met Lys Asp Tyr Pro Ser Ile Lys Leu Ile Ile Asn Ser Ile Thr 
145                 150                 155                 160 


Thr Arg Ile Glu Phe Thr Thr Arg Gln Leu Pro Asp Leu Glu Asp Leu 
                165                 170                 175     


Lys Lys Gln Glu Leu His Met Phe Ser Val Ile Pro Asn Lys Phe Leu 
            180                 185                 190         


Pro Asn Ser Lys Ser Pro Cys Trp Tyr Glu Glu Phe Ser Gly Gln Asn 
        195                 200                 205             


Thr Thr Asp Pro Tyr Leu Thr Asn Ser Tyr Val Leu Tyr Ser Lys Arg 
    210                 215                 220                 


Phe Arg Ser Thr Phe Asp Ala Leu Arg Lys Ala Phe Trp Gly His Leu 
225                 230                 235                 240 


Ala His Ala His Gly Lys His Phe Arg Leu Arg Cys Leu Pro His Phe 
                245                 250                 255     


Tyr Ile Ile Gly Gln Pro Lys Cys Gly Thr Thr Asp Leu Tyr Asp Arg 
            260                 265                 270         


Leu Arg Leu His Pro Glu Val Lys Phe Ser Ala Ile Lys Glu Pro His 
        275                 280                 285             


Trp Trp Thr Arg Lys Arg Phe Gly Ile Val Arg Leu Arg Asp Gly Leu 
    290                 295                 300                 


Arg Asp Arg Tyr Pro Val Glu Asp Tyr Leu Asp Leu Phe Asp Leu Ala 
305                 310                 315                 320 


Ala His Gln Ile His Gln Gly Leu Gln Ala Ser Ser Ala Lys Glu Gln 
                325                 330                 335     


Ser Lys Met Asn Thr Ile Ile Ile Gly Glu Ala Ser Ala Ser Thr Met 
            340                 345                 350         


Trp Asp Asn Asn Ala Trp Thr Phe Phe Tyr Asp Asn Ser Thr Asp Gly 
        355                 360                 365             


Glu Pro Pro Phe Leu Thr Gln Asp Phe Ile His Ala Phe Gln Pro Asn 
    370                 375                 380                 


Ala Arg Leu Ile Val Met Leu Arg Asp Pro Val Glu Arg Leu Tyr Ser 
385                 390                 395                 400 


Asp Tyr Leu Tyr Phe Ala Ser Ser Asn Lys Ser Ala Asp Asp Phe His 
                405                 410                 415     


Glu Lys Val Thr Glu Ala Leu Gln Leu Phe Glu Asn Cys Met Leu Asp 
            420                 425                 430         


Tyr Ser Leu Arg Ala Cys Val Tyr Asn Asn Thr Leu Asn Asn Ala Met 
        435                 440                 445             


Pro Val Arg Leu Gln Val Gly Leu Tyr Ala Val Tyr Leu Leu Asp Trp 
    450                 455                 460                 


Leu Ser Val Phe Asp Lys Gln Gln Phe Leu Ile Leu Arg Leu Glu Asp 
465                 470                 475                 480 


His Ala Ser Asn Val Lys Tyr Thr Met His Lys Val Phe Gln Phe Leu 
                485                 490                 495     


Asn Leu Gly Pro Leu Ser Glu Lys Gln Glu Ala Leu Met Thr Lys Ser 
            500                 505                 510         


Pro Ala Ser Asn Ala Arg Arg Pro Glu Asp Arg Asn Leu Gly Pro Met 
        515                 520                 525             


Trp Pro Ile Thr Gln Lys Ile Leu Arg Asp Phe Tyr Arg Pro Phe Asn 
    530                 535                 540                 


Ala Arg Leu Ala Gln Val Leu Ala Asp Glu Ala Phe Ala Trp Lys Thr 
545                 550                 555                 560 


Thr 
    


<210>  4130
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  4130

Met Lys Val Leu Arg Ala Trp Leu Leu Cys Leu Leu Met Leu Gly Leu 
1               5                   10                  15      


Ala Leu Arg Gly Ala Ala Ser Arg Thr His Arg His Ser Met Glu Ile 
            20                  25                  30          


Arg Thr Pro Asp Ile Asn Pro Ala Trp Tyr Ala Ser Arg Gly Ile Arg 
        35                  40                  45              


Pro Val Gly Arg Phe Gly Arg Arg Arg Ala Thr Leu Gly Asp Val Pro 
    50                  55                  60                  


Lys Pro Gly Leu Arg Pro Arg Leu Thr Cys Phe Pro Leu Glu Gly Gly 
65                  70                  75                  80  


Ala Met Ser Ser Gln Asp Gly 
                85          


<210>  4131
<211>  2371
<212>  PRT
<213>  Homo sapiens

<400>  4131

Met Ala Ala Pro Glu Ser Gly Pro Ala Leu Ser Pro Gly Thr Ala Glu 
1               5                   10                  15      


Gly Glu Glu Glu Thr Ile Leu Tyr Asp Leu Leu Val Asn Thr Glu Trp 
            20                  25                  30          


Pro Pro Glu Thr Glu Val Gln Pro Arg Gly Asn Gln Lys His Gly Ala 
        35                  40                  45              


Ser Phe Ile Ile Thr Lys Ala Ile Arg Asp Arg Leu Leu Phe Leu Arg 
    50                  55                  60                  


Gln Tyr Ile Trp Tyr Ser Pro Ala Pro Phe Leu Leu Pro Asp Gly Leu 
65                  70                  75                  80  


Val Arg Leu Val Asn Lys Gln Ile Asn Trp His Leu Val Leu Ala Ser 
                85                  90                  95      


Asn Gly Lys Leu Leu Ala Ala Val Gln Asp Gln Cys Val Glu Ile Arg 
            100                 105                 110         


Ser Ala Lys Asp Asp Phe Thr Ser Ile Ile Gly Lys Cys Gln Val Pro 
        115                 120                 125             


Lys Asp Pro Lys Pro Gln Trp Arg Arg Val Ala Trp Ser Tyr Asp Cys 
    130                 135                 140                 


Thr Leu Leu Ala Tyr Ala Glu Ser Thr Gly Thr Val Arg Val Phe Asp 
145                 150                 155                 160 


Leu Met Gly Ser Glu Leu Phe Val Ile Ser Pro Ala Ser Ser Phe Ile 
                165                 170                 175     


Gly Asp Leu Ser Tyr Ala Ile Ala Gly Leu Ile Phe Leu Glu Tyr Lys 
            180                 185                 190         


Ala Ser Ala Gln Trp Ser Ala Glu Leu Leu Val Ile Asn Tyr Arg Gly 
        195                 200                 205             


Glu Leu Arg Ser Tyr Leu Val Ser Val Gly Thr Asn Gln Ser Tyr Gln 
    210                 215                 220                 


Glu Ser His Cys Phe Ser Phe Ser Ser His Tyr Pro His Gly Ile Asn 
225                 230                 235                 240 


Thr Ala Ile Tyr His Pro Gly His Arg Leu Leu Leu Val Gly Gly Cys 
                245                 250                 255     


Glu Thr Ala Glu Val Gly Met Ser Lys Ala Ser Ser Cys Gly Leu Ser 
            260                 265                 270         


Ala Trp Arg Val Leu Ser Gly Ser Pro Tyr Tyr Lys Gln Val Thr Asn 
        275                 280                 285             


Gly Gly Asp Gly Val Thr Ala Val Pro Lys Thr Leu Gly Leu Leu Arg 
    290                 295                 300                 


Met Leu Ser Val Lys Phe Tyr Ser Arg Gln Gly Gln Glu Gln Asp Gly 
305                 310                 315                 320 


Ile Phe Lys Met Ser Leu Ser Pro Asp Gly Met Leu Leu Ala Ala Ile 
                325                 330                 335     


His Phe Ser Gly Lys Leu Ser Ile Trp Ala Ile Pro Ser Leu Lys Gln 
            340                 345                 350         


Gln Gly Glu Trp Gly Gln Asn Glu Gln Pro Gly Tyr Asp Asp Leu Asn 
        355                 360                 365             


Pro Asp Trp Arg Leu Ser Thr Glu Lys Arg Lys Lys Ile Lys Asp Lys 
    370                 375                 380                 


Glu Ser Phe Tyr Pro Leu Ile Asp Val Asn Trp Trp Ala Asp Ser Ala 
385                 390                 395                 400 


Val Thr Leu Ala Arg Cys Ser Gly Ala Leu Thr Val Ser Ser Val Lys 
                405                 410                 415     


Thr Leu Lys Asn Leu Leu Gly Lys Ser Cys Glu Trp Phe Glu Pro Ser 
            420                 425                 430         


Pro Gln Val Thr Ala Thr His Asp Gly Gly Phe Leu Ser Leu Glu Cys 
        435                 440                 445             


Glu Ile Lys Leu Ala Pro Lys Arg Ser Arg Leu Glu Thr Arg Ala Gly 
    450                 455                 460                 


Glu Glu Asp Glu Gly Glu Glu Asp Ser Asp Ser Asp Tyr Glu Ile Ser 
465                 470                 475                 480 


Ala Lys Ala Arg Tyr Phe Gly Tyr Ile Lys Gln Gly Leu Tyr Leu Val 
                485                 490                 495     


Thr Glu Met Glu Arg Phe Ala Pro Pro Arg Lys Arg Pro Arg Thr Ile 
            500                 505                 510         


Thr Lys Asn Tyr Arg Leu Val Ser Leu Arg Ser Thr Thr Pro Glu Glu 
        515                 520                 525             


Leu Tyr Gln Arg Lys Ile Glu Ser Glu Glu Tyr Glu Glu Ala Leu Ser 
    530                 535                 540                 


Leu Ala His Thr Tyr Gly Leu Asp Thr Asp Leu Val Tyr Gln Arg Gln 
545                 550                 555                 560 


Trp Arg Lys Ser Ala Val Asn Val Ala Ser Ile Gln Asn Tyr Leu Ser 
                565                 570                 575     


Lys Ile Lys Lys Arg Ser Trp Val Leu His Glu Cys Leu Glu Arg Val 
            580                 585                 590         


Pro Glu Asn Val Asp Ala Ala Lys Glu Leu Leu Gln Tyr Gly Leu Lys 
        595                 600                 605             


Gly Thr Asp Leu Glu Ala Leu Leu Ala Ile Gly Lys Gly Ala Asp Asp 
    610                 615                 620                 


Gly Arg Phe Thr Leu Pro Gly Glu Ile Asp Ile Asp Ser Ile Ser Tyr 
625                 630                 635                 640 


Glu Glu Leu Ser Pro Pro Asp Glu Glu Pro Ala Lys Asn Lys Lys Glu 
                645                 650                 655     


Lys Glu Leu Lys Lys Arg Gln Glu Leu Leu Lys Leu Val Asn Phe Ser 
            660                 665                 670         


Lys Leu Thr Leu Glu Gln Lys Glu Leu Cys Arg Cys Arg Arg Lys Leu 
        675                 680                 685             


Leu Thr Tyr Leu Asp Arg Leu Ala Thr Tyr Glu Glu Ile Leu Gly Val 
    690                 695                 700                 


Pro His Ala Ser Glu Gln Arg Tyr Asp Ala Glu Phe Phe Lys Lys Phe 
705                 710                 715                 720 


Arg Asn Gln Asn Ile Val Leu Ser Ala Arg Thr Tyr Ala Gln Glu Ser 
                725                 730                 735     


Asn Val Gln Ala Leu Glu Ile Leu Phe Thr Tyr His Gly Ser Asp Leu 
            740                 745                 750         


Leu Pro His Arg Leu Ala Ile Leu Ser Asn Phe Pro Glu Thr Thr Ser 
        755                 760                 765             


Pro His Glu Tyr Ser Val Leu Leu Pro Glu Ala Cys Phe Asn Gly Asp 
    770                 775                 780                 


Ser Leu Met Ile Ile Pro Trp His Glu His Lys His Arg Ala Lys Asp 
785                 790                 795                 800 


Trp Cys Glu Glu Leu Ala Cys Arg Met Val Val Glu Pro Asn Leu Gln 
                805                 810                 815     


Asp Glu Ser Glu Phe Leu Tyr Ala Ala Gln Pro Glu Leu Leu Arg Phe 
            820                 825                 830         


Arg Met Thr Gln Leu Thr Val Glu Lys Val Met Asp Trp Tyr Gln Thr 
        835                 840                 845             


Arg Ala Glu Glu Ile Glu His Tyr Ala Arg Gln Val Asp Cys Ala Leu 
    850                 855                 860                 


Ser Leu Ile Arg Leu Gly Met Glu Arg Asn Ile Pro Gly Leu Leu Val 
865                 870                 875                 880 


Leu Cys Asp Asn Leu Val Thr Leu Glu Thr Leu Val Tyr Glu Ala Arg 
                885                 890                 895     


Cys Asp Val Thr Leu Thr Leu Lys Glu Leu Gln Gln Met Lys Asp Ile 
            900                 905                 910         


Glu Lys Leu Arg Leu Leu Met Asn Ser Cys Ser Glu Asp Lys Tyr Val 
        915                 920                 925             


Thr Ser Ala Tyr Gln Trp Met Val Pro Phe Leu His Arg Cys Glu Lys 
    930                 935                 940                 


Gln Ser Pro Gly Val Ala Asn Glu Leu Leu Lys Glu Tyr Leu Val Thr 
945                 950                 955                 960 


Leu Ala Lys Gly Asp Leu Lys Phe Pro Leu Lys Ile Phe Gln His Ser 
                965                 970                 975     


Lys Pro Asp Leu Gln Gln Lys Ile Ile Pro Asp Gln Asp Gln Leu Met 
            980                 985                 990         


Ala Ile Ala Leu Glu Cys Ile Tyr  Thr Cys Glu Arg Asn  Asp Gln Leu 
        995                 1000                 1005             


Cys Leu  Cys Tyr Asp Leu Leu  Glu Cys Leu Pro Glu  Arg Gly Tyr 
    1010                 1015                 1020             


Gly Asp  Lys Thr Glu Ala Thr  Thr Lys Leu His Asp  Met Val Asp 
    1025                 1030                 1035             


Gln Leu  Glu Gln Ile Leu Ser  Val Ser Glu Leu Leu  Glu Lys His 
    1040                 1045                 1050             


Gly Leu  Glu Lys Pro Ile Ser  Phe Val Lys Asn Thr  Gln Ser Ser 
    1055                 1060                 1065             


Ser Glu  Glu Ala Arg Lys Leu  Met Val Arg Leu Thr  Arg His Thr 
    1070                 1075                 1080             


Gly Arg  Lys Gln Pro Pro Val  Ser Glu Ser His Trp  Arg Thr Leu 
    1085                 1090                 1095             


Leu Gln  Asp Met Leu Thr Met  Gln Gln Asn Val Tyr  Thr Cys Leu 
    1100                 1105                 1110             


Asp Ser  Asp Ala Cys Tyr Glu  Ile Phe Thr Glu Ser  Leu Leu Cys 
    1115                 1120                 1125             


Ser Ser  Arg Leu Glu Asn Ile  His Leu Ala Gly Gln  Met Met His 
    1130                 1135                 1140             


Cys Ser  Ala Cys Ser Glu Asn  Pro Pro Ala Gly Ile  Ala His Lys 
    1145                 1150                 1155             


Gly Lys  Pro His Tyr Arg Val  Ser Tyr Glu Lys Ser  Ile Asp Leu 
    1160                 1165                 1170             


Val Leu  Ala Ala Ser Arg Glu  Tyr Phe Asn Ser Ser  Thr Asn Leu 
    1175                 1180                 1185             


Thr Asp  Ser Cys Met Asp Leu  Ala Arg Cys Cys Leu  Gln Leu Ile 
    1190                 1195                 1200             


Thr Asp  Arg Pro Pro Ala Ile  Gln Glu Glu Leu Asp  Leu Ile Gln 
    1205                 1210                 1215             


Ala Val  Gly Cys Leu Glu Glu  Phe Gly Val Lys Ile  Leu Pro Leu 
    1220                 1225                 1230             


Gln Val  Arg Leu Cys Pro Asp  Arg Ile Ser Leu Ile  Lys Glu Cys 
    1235                 1240                 1245             


Ile Ser  Gln Ser Pro Thr Cys  Tyr Lys Gln Ser Thr  Lys Leu Leu 
    1250                 1255                 1260             


Gly Leu  Ala Glu Leu Leu Arg  Val Ala Gly Glu Asn  Pro Glu Glu 
    1265                 1270                 1275             


Arg Arg  Gly Gln Val Leu Ile  Leu Leu Val Glu Gln  Ala Leu Arg 
    1280                 1285                 1290             


Phe His  Asp Tyr Lys Ala Ala  Ser Met His Cys Gln  Glu Leu Met 
    1295                 1300                 1305             


Ala Thr  Gly Tyr Pro Lys Ser  Trp Asp Val Cys Ser  Gln Leu Gly 
    1310                 1315                 1320             


Gln Ser  Glu Gly Tyr Gln Asp  Leu Ala Thr Arg Gln  Glu Leu Met 
    1325                 1330                 1335             


Ala Phe  Ala Leu Thr His Cys  Pro Pro Ser Ser Ile  Glu Leu Leu 
    1340                 1345                 1350             


Leu Ala  Ala Ser Ser Ser Leu  Gln Thr Glu Ile Leu  Tyr Gln Arg 
    1355                 1360                 1365             


Val Asn  Phe Gln Ile His His  Glu Gly Gly Glu Asn  Ile Ser Ala 
    1370                 1375                 1380             


Ser Pro  Leu Thr Ser Lys Ala  Val Gln Glu Asp Glu  Val Gly Val 
    1385                 1390                 1395             


Pro Gly  Ser Asn Ser Ala Asp  Leu Leu Arg Trp Thr  Thr Ala Thr 
    1400                 1405                 1410             


Thr Met  Lys Val Leu Ser Asn  Thr Thr Thr Thr Thr  Lys Ala Val 
    1415                 1420                 1425             


Leu Gln  Ala Val Ser Asp Gly  Gln Trp Trp Lys Lys  Ser Leu Thr 
    1430                 1435                 1440             


Tyr Leu  Arg Pro Leu Gln Gly  Gln Lys Cys Gly Gly  Ala Tyr Gln 
    1445                 1450                 1455             


Ile Gly  Thr Thr Ala Asn Glu  Asp Leu Glu Lys Gln  Gly Cys His 
    1460                 1465                 1470             


Pro Phe  Tyr Glu Ser Val Ile  Ser Asn Pro Phe Val  Ala Glu Ser 
    1475                 1480                 1485             


Glu Gly  Thr Tyr Asp Thr Tyr  Gln His Val Pro Val  Glu Ser Phe 
    1490                 1495                 1500             


Ala Glu  Val Leu Leu Arg Thr  Gly Lys Leu Ala Glu  Ala Lys Asn 
    1505                 1510                 1515             


Lys Gly  Glu Val Phe Pro Thr  Thr Glu Val Leu Leu  Gln Leu Ala 
    1520                 1525                 1530             


Ser Glu  Ala Leu Pro Asn Asp  Met Thr Leu Ala Leu  Ala Tyr Leu 
    1535                 1540                 1545             


Leu Ala  Leu Pro Gln Val Leu  Asp Ala Asn Arg Cys  Phe Glu Lys 
    1550                 1555                 1560             


Gln Ser  Pro Ser Ala Leu Ser  Leu Gln Leu Ala Ala  Tyr Tyr Tyr 
    1565                 1570                 1575             


Ser Leu  Gln Ile Tyr Ala Arg  Leu Ala Pro Cys Phe  Arg Asp Lys 
    1580                 1585                 1590             


Cys His  Pro Leu Tyr Arg Ala  Asp Pro Lys Glu Leu  Ile Lys Met 
    1595                 1600                 1605             


Val Thr  Arg His Val Thr Arg  His Glu His Glu Ala  Trp Pro Glu 
    1610                 1615                 1620             


Asp Leu  Ile Ser Leu Thr Lys  Gln Leu His Cys Tyr  Asn Glu Arg 
    1625                 1630                 1635             


Leu Leu  Asp Phe Thr Gln Ala  Gln Ile Leu Gln Gly  Leu Arg Lys 
    1640                 1645                 1650             


Gly Val  Asp Val Gln Arg Phe  Thr Ala Asp Asp Gln  Tyr Lys Arg 
    1655                 1660                 1665             


Glu Thr  Ile Leu Gly Leu Ala  Glu Thr Leu Glu Glu  Ser Val Tyr 
    1670                 1675                 1680             


Ser Ile  Ala Ile Ser Leu Ala  Gln Arg Tyr Ser Val  Ser Arg Trp 
    1685                 1690                 1695             


Glu Val  Phe Met Thr His Leu  Glu Phe Leu Phe Thr  Asp Ser Gly 
    1700                 1705                 1710             


Leu Ser  Thr Leu Glu Ile Glu  Asn Arg Ala Gln Asp  Leu His Leu 
    1715                 1720                 1725             


Phe Glu  Thr Leu Lys Thr Asp  Pro Glu Ala Phe His  Gln His Met 
    1730                 1735                 1740             


Val Lys  Tyr Ile Tyr Pro Thr  Ile Gly Gly Phe Asp  His Glu Arg 
    1745                 1750                 1755             


Leu Gln  Tyr Tyr Phe Thr Leu  Leu Glu Asn Cys Gly  Cys Ala Asp 
    1760                 1765                 1770             


Leu Gly  Asn Cys Ala Ile Lys  Pro Glu Thr His Ile  Arg Leu Leu 
    1775                 1780                 1785             


Lys Lys  Phe Lys Val Val Ala  Ser Gly Leu Asn Tyr  Lys Lys Leu 
    1790                 1795                 1800             


Thr Asp  Glu Asn Met Ser Pro  Leu Glu Ala Leu Glu  Pro Val Leu 
    1805                 1810                 1815             


Ser Ser  Gln Asn Ile Leu Ser  Ile Ser Lys Leu Val  Pro Lys Ile 
    1820                 1825                 1830             


Pro Glu  Lys Asp Gly Gln Met  Leu Ser Pro Ser Ser  Leu Tyr Thr 
    1835                 1840                 1845             


Ile Trp  Leu Gln Lys Leu Phe  Trp Thr Gly Asp Pro  His Leu Ile 
    1850                 1855                 1860             


Lys Gln  Val Pro Gly Ser Ser  Pro Glu Trp Leu His  Ala Tyr Asp 
    1865                 1870                 1875             


Val Cys  Met Lys Tyr Phe Asp  Arg Leu His Pro Gly  Asp Leu Ile 
    1880                 1885                 1890             


Thr Val  Val Asp Ala Val Thr  Phe Ser Pro Lys Ala  Val Thr Lys 
    1895                 1900                 1905             


Leu Ser  Val Glu Ala Arg Lys  Glu Met Thr Arg Lys  Ala Ile Lys 
    1910                 1915                 1920             


Thr Val  Lys His Phe Ile Glu  Lys Pro Arg Lys Arg  Asn Ser Glu 
    1925                 1930                 1935             


Asp Glu  Ala Gln Glu Ala Lys  Asp Ser Lys Val Thr  Tyr Ala Asp 
    1940                 1945                 1950             


Thr Leu  Asn His Leu Glu Lys  Ser Leu Ala His Leu  Glu Thr Leu 
    1955                 1960                 1965             


Ser His  Ser Phe Ile Leu Ser  Leu Lys Asn Ser Glu  Gln Glu Thr 
    1970                 1975                 1980             


Leu Gln  Lys Tyr Ser His Leu  Tyr Asp Leu Ser Arg  Ser Glu Lys 
    1985                 1990                 1995             


Glu Lys  Leu His Asp Glu Ala  Val Ala Ile Cys Leu  Asp Gly Gln 
    2000                 2005                 2010             


Pro Leu  Ala Met Ile Gln Gln  Leu Leu Glu Val Ala  Val Gly Pro 
    2015                 2020                 2025             


Leu Asp  Ile Ser Pro Lys Asp  Ile Val Gln Ser Ala  Ile Met Lys 
    2030                 2035                 2040             


Ile Ile  Ser Ala Leu Ser Gly  Gly Ser Ala Asp Leu  Gly Gly Pro 
    2045                 2050                 2055             


Arg Asp  Pro Leu Lys Val Leu  Glu Gly Val Val Ala  Ala Val His 
    2060                 2065                 2070             


Ala Ser  Val Asp Lys Gly Glu  Glu Leu Val Ser Pro  Glu Asp Leu 
    2075                 2080                 2085             


Leu Glu  Trp Leu Arg Pro Phe  Cys Ala Asp Asp Ala  Trp Pro Val 
    2090                 2095                 2100             


Arg Pro  Arg Ile His Val Leu  Gln Ile Leu Gly Gln  Ser Phe His 
    2105                 2110                 2115             


Leu Thr  Glu Glu Asp Ser Lys  Leu Leu Val Phe Phe  Arg Thr Glu 
    2120                 2125                 2130             


Ala Ile  Leu Lys Ala Ser Trp  Pro Gln Arg Gln Val  Asp Ile Ala 
    2135                 2140                 2145             


Asp Ile  Glu Asn Glu Glu Asn  Arg Tyr Cys Leu Phe  Met Glu Leu 
    2150                 2155                 2160             


Leu Glu  Ser Ser His His Glu  Ala Glu Phe Gln His  Leu Val Leu 
    2165                 2170                 2175             


Leu Leu  Gln Ala Trp Pro Pro  Met Lys Ser Glu Tyr  Val Ile Thr 
    2180                 2185                 2190             


Asn Asn  Pro Trp Val Arg Leu  Ala Thr Val Met Leu  Thr Arg Cys 
    2195                 2200                 2205             


Thr Met  Glu Asn Lys Glu Gly  Leu Gly Asn Glu Val  Leu Lys Met 
    2210                 2215                 2220             


Cys Arg  Ser Leu Tyr Asn Thr  Lys Gln Met Leu Pro  Ala Glu Gly 
    2225                 2230                 2235             


Val Lys  Glu Leu Cys Leu Leu  Leu Leu Asn Gln Ser  Leu Leu Leu 
    2240                 2245                 2250             


Pro Ser  Leu Lys Leu Leu Leu  Glu Ser Arg Asp Glu  His Leu His 
    2255                 2260                 2265             


Glu Met  Ala Leu Glu Gln Ile  Thr Ala Val Thr Thr  Val Asn Asp 
    2270                 2275                 2280             


Ser Asn  Cys Asp Gln Glu Leu  Leu Ser Leu Leu Leu  Asp Ala Lys 
    2285                 2290                 2295             


Leu Leu  Val Lys Cys Val Ser  Thr Pro Phe Tyr Pro  Arg Ile Val 
    2300                 2305                 2310             


Asp His  Leu Leu Ala Ser Leu  Gln Gln Gly Arg Trp  Asp Ala Glu 
    2315                 2320                 2325             


Glu Leu  Gly Arg His Leu Arg  Glu Ala Gly His Glu  Ala Glu Ala 
    2330                 2335                 2340             


Gly Ser  Leu Leu Leu Ala Val  Arg Gly Thr His Gln  Ala Phe Arg 
    2345                 2350                 2355             


Thr Phe  Ser Thr Ala Leu Arg  Ala Ala Gln His Trp  Val 
    2360                 2365                 2370     


<210>  4132
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  4132

Met Glu Thr Arg Pro Arg Leu Gly Ala Thr Cys Leu Leu Gly Phe Ser 
1               5                   10                  15      


Phe Leu Leu Leu Val Ile Ser Ser Asp Gly His Asn Gly Leu Gly Lys 
            20                  25                  30          


Gly Phe Gly Asp His Ile His Trp Arg Thr Leu Glu Asp Gly Lys Lys 
        35                  40                  45              


Glu Ala Ala Ala Ser Gly Leu Pro Leu Met Val Ile Ile His Lys Ser 
    50                  55                  60                  


Trp Cys Gly Ala Cys Lys Ala Leu Lys Pro Lys Phe Ala Glu Ser Thr 
65                  70                  75                  80  


Glu Ile Ser Glu Leu Ser His Asn Phe Val Met Val Asn Leu Glu Asp 
                85                  90                  95      


Glu Glu Glu Pro Lys Asp Glu Asp Phe Ser Pro Asp Gly Gly Tyr Ile 
            100                 105                 110         


Pro Arg Ile Leu Phe Leu Asp Pro Ser Gly Lys Val His Pro Glu Ile 
        115                 120                 125             


Ile Asn Glu Asn Gly Asn Pro Ser Tyr Lys Tyr Phe Tyr Val Ser Ala 
    130                 135                 140                 


Glu Gln Val Val Gln Gly Met Lys Glu Ala Gln Glu Arg Leu Thr Gly 
145                 150                 155                 160 


Asp Ala Phe Arg Lys Lys His Leu Glu Asp Glu Leu 
                165                 170         


<210>  4133
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  4133

Met Glu Thr Arg Pro Arg Leu Gly Ala Thr Cys Leu Leu Gly Phe Ser 
1               5                   10                  15      


Phe Leu Leu Leu Val Ile Ser Ser Asp Gly His Asn Gly Leu Gly Lys 
            20                  25                  30          


Gly Phe Gly Asp His Ile His Trp Arg Thr Leu Glu Asp Gly Lys Lys 
        35                  40                  45              


Glu Ala Ala Ala Ser Gly Leu Pro Leu Met Val Ile Ile His Lys Ser 
    50                  55                  60                  


Trp Cys Gly Ala Cys Lys Ala Leu Lys Pro Lys Phe Ala Glu Ser Thr 
65                  70                  75                  80  


Glu Ile Ser Glu Leu Ser His Asn Phe Val Met Val Asn Leu Glu Asp 
                85                  90                  95      


Glu Glu Glu Pro Lys Asp Glu Asp Phe Ser Pro Asp Gly Gly Tyr Ile 
            100                 105                 110         


Pro Arg Ile Leu Phe Leu Asp Pro Ser Gly Lys Val His Pro Glu Ile 
        115                 120                 125             


Ile Asn Glu Asn Gly Asn Pro Ser Tyr Lys Tyr Phe Tyr Val Ser Ala 
    130                 135                 140                 


Glu Gln Val Val Gln Gly Met Lys Glu Ala Gln Glu Arg Leu Thr Gly 
145                 150                 155                 160 


Asp Ala Phe Arg Lys Lys His Leu Glu Asp Glu Leu 
                165                 170         


<210>  4134
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  4134

Met Ala Lys Asn Arg Arg Asp Arg Asn Ser Trp Gly Gly Phe Ser Glu 
1               5                   10                  15      


Lys Thr Tyr Glu Trp Ser Ser Glu Glu Glu Glu Pro Val Lys Lys Ala 
            20                  25                  30          


Gly Pro Val Gln Val Leu Ile Val Lys Asp Asp His Ser Phe Glu Leu 
        35                  40                  45              


Asp Glu Thr Ala Leu Asn Arg Ile Leu Leu Ser Glu Ala Val Arg Asp 
    50                  55                  60                  


Lys Glu Val Val Ala Val Ser Val Ala Gly Ala Phe Arg Lys Gly Lys 
65                  70                  75                  80  


Ser Phe Leu Met Asp Phe Met Leu Arg Tyr Met Tyr Asn Gln Glu Ser 
                85                  90                  95      


Val Asp Trp Val Gly Asp Tyr Asn Glu Pro Leu Thr Gly Phe Ser Trp 
            100                 105                 110         


Arg Gly Gly Ser Glu Arg Glu Thr Thr Gly Ile Gln Ile Trp Ser Glu 
        115                 120                 125             


Ile Phe Leu Ile Asn Lys Pro Asp Gly Lys Lys Val Ala Val Leu Leu 
    130                 135                 140                 


Met Asp Thr Gln Gly Thr Phe Asp Ser Gln Ser Thr Leu Arg Asp Ser 
145                 150                 155                 160 


Ala Thr Val Phe Ala Leu Ser Thr Met Ile Ser Ser Ile Gln Val Tyr 
                165                 170                 175     


Asn Leu Ser Gln Asn Val Gln Glu Asp Asp Leu Gln His Leu Gln Leu 
            180                 185                 190         


Phe Thr Glu Tyr Gly Arg Leu Ala Met Glu Glu Thr Phe Leu Lys Pro 
        195                 200                 205             


Phe Gln Ser Leu Ile Phe Leu Val Arg Asp Trp Ser Phe Pro Tyr Glu 
    210                 215                 220                 


Phe Ser Tyr Gly Ala Asp Gly Gly Ala Lys Phe Leu Glu Lys Arg Leu 
225                 230                 235                 240 


Lys Val Ser Gly Asn Gln His Glu Glu Leu Gln Asn Val Arg Lys His 
                245                 250                 255     


Ile His Ser Cys Phe Thr Asn Ile Ser Cys Phe Leu Leu Pro His Pro 
            260                 265                 270         


Gly Leu Lys Val Ala Thr Asn Pro Asn Phe Asp Gly Lys Leu Lys Glu 
        275                 280                 285             


Ile Asp Asp Glu Phe Ile Lys Asn Leu Lys Ile Leu Ile Pro Trp Leu 
    290                 295                 300                 


Leu Ser Pro Glu Ser Leu Asp Ile Lys Glu Ile Asn Gly Asn Lys Ile 
305                 310                 315                 320 


Thr Cys Arg Gly Leu Val Glu Tyr Phe Lys Ala Tyr Ile Lys Ile Tyr 
                325                 330                 335     


Gln Gly Glu Glu Leu Pro His Pro Lys Ser Met Leu Gln Ala Thr Ala 
            340                 345                 350         


Glu Ala Asn Asn Leu Ala Ala Val Ala Thr Ala Lys Asp Thr Tyr Asn 
        355                 360                 365             


Lys Lys Met Glu Glu Ile Cys Gly Gly Asp Lys Pro Phe Leu Ala Pro 
    370                 375                 380                 


Asn Asp Leu Gln Thr Lys His Leu Gln Leu Lys Glu Glu Ser Val Lys 
385                 390                 395                 400 


Leu Phe Arg Gly Val Lys Lys Met Gly Gly Glu Glu Phe Ser Arg Arg 
                405                 410                 415     


Tyr Leu Gln Gln Leu Glu Ser Glu Ile Asp Glu Leu Tyr Ile Gln Tyr 
            420                 425                 430         


Ile Lys His Asn Asp Ser Lys Asn Ile Phe His Ala Ala Arg Thr Pro 
        435                 440                 445             


Ala Thr Leu Phe Val Val Ile Phe Ile Thr Tyr Val Ile Ala Gly Val 
    450                 455                 460                 


Thr Gly Phe Ile Gly Leu Asp Ile Ile Ala Ser Leu Cys Asn Met Ile 
465                 470                 475                 480 


Met Gly Leu Thr Leu Ile Thr Leu Cys Thr Trp Ala Tyr Ile Arg Tyr 
                485                 490                 495     


Ser Gly Glu Tyr Arg Glu Leu Gly Ala Val Ile Asp Gln Val Ala Ala 
            500                 505                 510         


Ala Leu Trp Asp Gln Gly Ser Thr Asn Glu Ala Leu Tyr Lys Leu Tyr 
        515                 520                 525             


Ser Ala Ala Ala Thr His Arg His Leu Tyr His Gln Ala Phe Pro Thr 
    530                 535                 540                 


Pro Lys Ser Glu Ser Thr Glu Gln Ser Glu Lys Lys Lys Met 
545                 550                 555             


<210>  4135
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  4135

Met Pro Ala Leu Leu Pro Val Ala Ser Arg Leu Leu Leu Leu Pro Arg 
1               5                   10                  15      


Val Leu Leu Thr Met Ala Ser Gly Ser Pro Pro Thr Gln Pro Ser Pro 
            20                  25                  30          


Ala Ser Asp Ser Gly Ser Gly Tyr Val Pro Gly Ser Val Ser Ala Ala 
        35                  40                  45              


Phe Val Thr Cys Pro Asn Glu Lys Val Ala Lys Glu Ile Ala Arg Ala 
    50                  55                  60                  


Val Val Glu Lys Arg Leu Ala Ala Cys Val Asn Leu Ile Pro Gln Ile 
65                  70                  75                  80  


Thr Ser Ile Tyr Glu Trp Lys Gly Lys Ile Glu Glu Asp Ser Glu Val 
                85                  90                  95      


Leu Met Met Ile Lys Thr Gln Ser Ser Leu Val Pro Ala Leu Thr Asp 
            100                 105                 110         


Phe Val Arg Ser Val His Pro Tyr Glu Val Ala Glu Val Ile Ala Leu 
        115                 120                 125             


Pro Val Glu Gln Gly Asn Phe Pro Tyr Leu Gln Trp Val Arg Gln Val 
    130                 135                 140                 


Thr Glu Ser Val Ser Asp Ser Ile Thr Val Leu Pro 
145                 150                 155     


<210>  4136
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  4136

Met Glu Pro Ala Val Ser Glu Pro Met Arg Asp Gln Val Ala Arg Thr 
1               5                   10                  15      


His Leu Thr Glu Asp Thr Pro Lys Val Asn Ala Asp Ile Glu Lys Val 
            20                  25                  30          


Asn Gln Asn Gln Ala Lys Arg Cys Thr Val Ile Gly Gly Ser Gly Phe 
        35                  40                  45              


Leu Gly Gln His Met Val Glu Gln Leu Leu Ala Arg Gly Tyr Ala Val 
    50                  55                  60                  


Asn Val Phe Asp Ile Gln Gln Gly Phe Asp Asn Pro Gln Val Arg Phe 
65                  70                  75                  80  


Phe Leu Gly Asp Leu Cys Ser Arg Gln Asp Leu Tyr Pro Ala Leu Lys 
                85                  90                  95      


Gly Val Asn Thr Val Phe His Cys Ala Ser Pro Pro Pro Ser Ser Asn 
            100                 105                 110         


Asn Lys Glu Leu Phe Tyr Arg Val Asn Tyr Ile Gly Thr Lys Asn Val 
        115                 120                 125             


Ile Glu Thr Cys Lys Glu Ala Gly Val Gln Lys Leu Ile Leu Thr Ser 
    130                 135                 140                 


Ser Ala Ser Val Ile Phe Glu Gly Val Asp Ile Lys Asn Gly Thr Glu 
145                 150                 155                 160 


Asp Leu Pro Tyr Ala Met Lys Pro Ile Asp Tyr Tyr Thr Glu Thr Lys 
                165                 170                 175     


Ile Leu Gln Glu Arg Ala Val Leu Gly Ala Asn Asp Pro Glu Lys Asn 
            180                 185                 190         


Phe Leu Thr Thr Ala Ile Arg Pro His Gly Ile Phe Gly Pro Arg Asp 
        195                 200                 205             


Pro Gln Leu Val Pro Ile Leu Ile Glu Ala Ala Arg Asn Gly Lys Met 
    210                 215                 220                 


Lys Phe Val Ile Gly Asn Gly Lys Asn Leu Val Asp Phe Thr Phe Val 
225                 230                 235                 240 


Glu Asn Val Val His Gly His Ile Leu Ala Ala Glu Gln Leu Ser Arg 
                245                 250                 255     


Asp Ser Thr Leu Gly Gly Lys Ala Phe His Ile Thr Asn Asp Glu Pro 
            260                 265                 270         


Ile Pro Phe Trp Thr Phe Leu Ser Arg Ile Leu Thr Gly Leu Asn Tyr 
        275                 280                 285             


Glu Ala Pro Lys Tyr His Ile Pro Tyr Trp Val Ala Tyr Tyr Leu Ala 
    290                 295                 300                 


Leu Leu Leu Ser Leu Leu Val Met Val Ile Ser Pro Val Ile Gln Leu 
305                 310                 315                 320 


Gln Pro Thr Phe Thr Pro Met Arg Val Ala Leu Ala Gly Thr Phe His 
                325                 330                 335     


Tyr Tyr Ser Cys Glu Arg Ala Lys Lys Ala Met Gly Tyr Gln Pro Leu 
            340                 345                 350         


Val Thr Met Asp Asp Ala Met Glu Arg Thr Val Gln Ser Phe Arg His 
        355                 360                 365             


Leu Arg Arg Val Lys 
    370             


<210>  4137
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  4137

Met Gln Gln Asp Gly Leu Gly Val Gly Thr Arg Asn Gly Ser Gly Lys 
1               5                   10                  15      


Gly Arg Ser Val His Pro Ser Trp Pro Trp Cys Ala Pro Arg Pro Leu 
            20                  25                  30          


Arg Tyr Phe Gly Arg Asp Ala Arg Ala Arg Arg Ala Gln Thr Ala Ala 
        35                  40                  45              


Met Ala Leu Leu Ala Gly Gly Leu Ser Arg Gly Leu Gly Ser His Pro 
    50                  55                  60                  


Ala Ala Ala Gly Arg Asp Ala Val Val Phe Val Trp Leu Leu Leu Ser 
65                  70                  75                  80  


Thr Trp Cys Thr Ala Pro Ala Arg Ala Ile Gln Val Thr Val Ser Asn 
                85                  90                  95      


Pro Tyr His Val Val Ile Leu Phe Gln Pro Val Thr Leu Pro Cys Thr 
            100                 105                 110         


Tyr Gln Met Thr Ser Thr Pro Thr Gln Pro Ile Val Ile Trp Lys Tyr 
        115                 120                 125             


Lys Ser Phe Cys Arg Asp Arg Ile Ala Asp Ala Phe Ser Pro Ala Ser 
    130                 135                 140                 


Val Asp Asn Gln Leu Asn Ala Gln Leu Ala Ala Gly Asn Pro Gly Tyr 
145                 150                 155                 160 


Asn Pro Tyr Val Glu Cys Gln Asp Ser Val Arg Thr Val Arg Val Val 
                165                 170                 175     


Ala Thr Lys Gln Gly Asn Ala Val Thr Leu Gly Asp Tyr Tyr Gln Gly 
            180                 185                 190         


Arg Arg Ile Thr Ile Thr Gly Asn Ala Asp Leu Thr Phe Asp Gln Thr 
        195                 200                 205             


Ala Trp Gly Asp Ser Gly Val Tyr Tyr Cys Ser Val Val Ser Ala Gln 
    210                 215                 220                 


Asp Leu Gln Gly Asn Asn Glu Ala Tyr Ala Glu Leu Ile Val Leu Asp 
225                 230                 235                 240 


Trp Leu Phe Val Val Val Val Cys Leu Ala Ala Phe Leu Ile Phe Leu 
                245                 250                 255     


Leu Leu Gly Ile Cys Trp Cys Gln Cys Cys Pro His Thr Cys Cys Cys 
            260                 265                 270         


Tyr Val Arg Cys Pro Cys Cys Pro Asp Lys Cys Cys Cys Pro Glu Ala 
        275                 280                 285             


Leu Tyr Ala Ala Gly Lys Ala Ala Thr Ser Gly Val Pro Ser Ile Tyr 
    290                 295                 300                 


Ala Pro Ser Thr Tyr Ala His Leu Ser Pro Ala Lys Thr Pro Pro Pro 
305                 310                 315                 320 


Pro Ala Met Ile Pro Met Gly Pro Ala Tyr Asn Gly Tyr Pro Gly Gly 
                325                 330                 335     


Tyr Pro Gly Asp Val Asp Arg Ser Ser Ser Ala Gly Gly Gln Gly Ser 
            340                 345                 350         


Tyr Val Pro Leu Leu Arg Asp Thr Asp Ser Ser Val Ala Ser Glu Val 
        355                 360                 365             


Arg Ser Gly Tyr Arg Ile Gln Ala Ser Gln Gln Asp Asp Ser Met Arg 
    370                 375                 380                 


Val Leu Tyr Tyr Met Glu Lys Glu Leu Ala Asn Phe Asp Pro Ser Arg 
385                 390                 395                 400 


Pro Gly Pro Pro Ser Gly Arg Val Glu Arg Ala Met Ser Glu Val Thr 
                405                 410                 415     


Ser Leu His Glu Asp Asp Trp Arg Ser Arg Pro Ser Arg Gly Pro Ala 
            420                 425                 430         


Leu Thr Pro Ile Arg Asp Glu Glu Trp Gly Gly His Ser Pro Arg Ser 
        435                 440                 445             


Pro Arg Gly Trp Asp Gln Glu Pro Ala Arg Glu Gln Ala Gly Gly Gly 
    450                 455                 460                 


Trp Arg Ala Arg Arg Pro Arg Ala Arg Ser Val Asp Ala Leu Asp Asp 
465                 470                 475                 480 


Leu Thr Pro Pro Ser Thr Ala Glu Ser Gly Ser Arg Ser Pro Thr Ser 
                485                 490                 495     


Asn Gly Gly Arg Ser Arg Ala Tyr Met Pro Pro Arg Ser Arg Ser Arg 
            500                 505                 510         


Asp Asp Leu Tyr Asp Gln Asp Asp Ser Arg Asp Phe Pro Arg Ser Arg 
        515                 520                 525             


Asp Pro His Tyr Asp Asp Phe Arg Ser Arg Glu Arg Pro Pro Ala Asp 
    530                 535                 540                 


Pro Arg Ser His His His Arg Thr Arg Asp Pro Arg Asp Asn Gly Ser 
545                 550                 555                 560 


Arg Ser Gly Asp Leu Pro Tyr Asp Gly Arg Leu Leu Glu Glu Ala Val 
                565                 570                 575     


Arg Lys Lys Gly Ser Glu Glu Arg Arg Arg Pro His Lys Glu Glu Glu 
            580                 585                 590         


Glu Glu Ala Tyr Tyr Pro Pro Ala Pro Pro Pro Tyr Ser Glu Thr Asp 
        595                 600                 605             


Ser Gln Ala Ser Arg Glu Arg Arg Leu Lys Lys Asn Leu Ala Leu Ser 
    610                 615                 620                 


Arg Glu Ser Leu Val Val 
625                 630 


<210>  4138
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  4138

Met Ser Asp Leu Leu Leu Leu Gly Leu Ile Gly Gly Leu Thr Leu Leu 
1               5                   10                  15      


Leu Leu Leu Thr Leu Leu Ala Phe Ala Gly Tyr Ser Gly Leu Leu Ala 
            20                  25                  30          


Gly Val Glu Val Ser Ala Gly Ser Pro Pro Ile Arg Asn Val Thr Val 
        35                  40                  45              


Ala Tyr Lys Phe His Met Gly Leu Tyr Gly Glu Thr Gly Arg Leu Phe 
    50                  55                  60                  


Thr Glu Ser Cys Ser Ile Ser Pro Lys Leu Arg Ser Ile Ala Val Tyr 
65                  70                  75                  80  


Tyr Asp Asn Pro His Met Val Pro Pro Asp Lys Cys Arg Cys Ala Val 
                85                  90                  95      


Gly Ser Ile Leu Ser Glu Gly Glu Glu Ser Pro Ser Pro Glu Leu Ile 
            100                 105                 110         


Asp Leu Tyr Gln Lys Phe Gly Phe Lys Val Phe Ser Phe Pro Ala Pro 
        115                 120                 125             


Ser His Val Val Thr Ala Thr Phe Pro Tyr Thr Thr Ile Leu Ser Ile 
    130                 135                 140                 


Trp Leu Ala Thr Arg Arg Val His Pro Ala Leu Asp Thr Tyr Ile Lys 
145                 150                 155                 160 


Glu Arg Lys Leu Cys Ala Tyr Pro Arg Leu Glu Ile Tyr Gln Glu Asp 
                165                 170                 175     


Gln Ile His Phe Met Cys Pro Leu Ala Arg Gln Gly Asp Phe Tyr Val 
            180                 185                 190         


Pro Glu Met Lys Glu Thr Glu Trp Lys Trp Arg Gly Leu Val Glu Ala 
        195                 200                 205             


Ile Asp Thr Gln Val Asp Gly Thr Gly Ala Asp Thr Met Ser Asp Thr 
    210                 215                 220                 


Ser Ser Val Ser Leu Glu Val Ser Pro Gly Ser Arg Glu Thr Ser Ala 
225                 230                 235                 240 


Ala Thr Leu Ser Pro Gly Ala Ser Ser Arg Gly Trp Asp Asp Gly Asp 
                245                 250                 255     


Thr Arg Ser Glu His Ser Tyr Ser Glu Ser Gly Ala Ser Gly Ser Ser 
            260                 265                 270         


Phe Glu Glu Leu Asp Leu Glu Gly Glu Gly Pro Leu Gly Glu Ser Arg 
        275                 280                 285             


Leu Asp Pro Gly Thr Glu Pro Leu Gly Thr Thr Lys Trp Leu Trp Glu 
    290                 295                 300                 


Pro Thr Ala Pro Glu Lys Gly Lys Glu 
305                 310             


<210>  4139
<211>  578
<212>  PRT
<213>  Homo sapiens

<400>  4139

Met Ala Ala Ala Met Pro Leu Ala Leu Leu Val Leu Leu Leu Leu Gly 
1               5                   10                  15      


Pro Gly Gly Trp Cys Leu Ala Glu Pro Pro Arg Asp Ser Leu Arg Glu 
            20                  25                  30          


Glu Leu Val Ile Thr Pro Leu Pro Ser Gly Asp Val Ala Ala Thr Phe 
        35                  40                  45              


Gln Phe Arg Thr Arg Trp Asp Ser Glu Leu Gln Arg Glu Gly Val Ser 
    50                  55                  60                  


His Tyr Arg Leu Phe Pro Lys Ala Leu Gly Gln Leu Ile Ser Lys Tyr 
65                  70                  75                  80  


Ser Leu Arg Glu Leu His Leu Ser Phe Thr Gln Gly Phe Trp Arg Thr 
                85                  90                  95      


Arg Tyr Trp Gly Pro Pro Phe Leu Gln Ala Pro Ser Gly Ala Glu Leu 
            100                 105                 110         


Trp Val Trp Phe Gln Asp Thr Val Thr Asp Val Asp Lys Ser Trp Lys 
        115                 120                 125             


Glu Leu Ser Asn Val Leu Ser Gly Ile Phe Cys Ala Ser Leu Asn Phe 
    130                 135                 140                 


Ile Asp Ser Thr Asn Thr Val Thr Pro Thr Ala Ser Phe Lys Pro Leu 
145                 150                 155                 160 


Gly Leu Ala Asn Asp Thr Asp His Tyr Phe Leu Arg Tyr Ala Val Leu 
                165                 170                 175     


Pro Arg Glu Val Val Cys Thr Glu Asn Leu Thr Pro Trp Lys Lys Leu 
            180                 185                 190         


Leu Pro Cys Ser Ser Lys Ala Gly Leu Ser Val Leu Leu Lys Ala Asp 
        195                 200                 205             


Arg Leu Phe His Thr Ser Tyr His Ser Gln Ala Val His Ile Arg Pro 
    210                 215                 220                 


Val Cys Arg Asn Ala Arg Cys Thr Ser Ile Ser Trp Glu Leu Arg Gln 
225                 230                 235                 240 


Thr Leu Ser Val Val Phe Asp Ala Phe Ile Thr Gly Gln Gly Lys Lys 
                245                 250                 255     


Asp Trp Ser Leu Phe Arg Met Phe Ser Arg Thr Leu Thr Glu Pro Cys 
            260                 265                 270         


Pro Leu Ala Ser Glu Ser Arg Val Tyr Val Asp Ile Thr Thr Tyr Asn 
        275                 280                 285             


Gln Asp Asn Glu Thr Leu Glu Val His Pro Pro Pro Thr Thr Thr Tyr 
    290                 295                 300                 


Gln Asp Val Ile Leu Gly Thr Arg Lys Thr Tyr Ala Ile Tyr Asp Leu 
305                 310                 315                 320 


Leu Asp Thr Ala Met Ile Asn Asn Ser Arg Asn Leu Asn Ile Gln Leu 
                325                 330                 335     


Lys Trp Lys Arg Pro Pro Glu Asn Glu Ala Pro Pro Val Pro Phe Leu 
            340                 345                 350         


His Ala Gln Arg Tyr Val Ser Gly Tyr Gly Leu Gln Lys Gly Glu Leu 
        355                 360                 365             


Ser Thr Leu Leu Tyr Asn Thr His Pro Tyr Arg Ala Phe Pro Val Leu 
    370                 375                 380                 


Leu Leu Asp Thr Val Pro Trp Tyr Leu Arg Leu Tyr Val His Thr Leu 
385                 390                 395                 400 


Thr Ile Thr Ser Lys Gly Lys Glu Asn Lys Pro Ser Tyr Ile His Tyr 
                405                 410                 415     


Gln Pro Ala Gln Asp Arg Leu Gln Pro His Leu Leu Glu Met Leu Ile 
            420                 425                 430         


Gln Leu Pro Ala Asn Ser Val Thr Lys Val Ser Ile Gln Phe Glu Arg 
        435                 440                 445             


Ala Leu Leu Lys Trp Thr Glu Tyr Thr Pro Asp Pro Asn His Gly Phe 
    450                 455                 460                 


Tyr Val Ser Pro Ser Val Leu Ser Ala Leu Val Pro Ser Met Val Ala 
465                 470                 475                 480 


Ala Lys Pro Val Asp Trp Glu Glu Ser Pro Leu Phe Asn Ser Leu Phe 
                485                 490                 495     


Pro Val Ser Asp Gly Ser Asn Tyr Phe Val Arg Leu Tyr Thr Glu Pro 
            500                 505                 510         


Leu Leu Val Asn Leu Pro Thr Pro Asp Phe Ser Met Pro Tyr Asn Val 
        515                 520                 525             


Ile Cys Leu Thr Cys Thr Val Val Ala Val Cys Tyr Gly Ser Phe Tyr 
    530                 535                 540                 


Asn Leu Leu Thr Arg Thr Phe His Ile Glu Glu Pro Arg Thr Gly Gly 
545                 550                 555                 560 


Leu Ala Lys Arg Leu Ala Asn Leu Ile Arg Arg Ala Arg Gly Val Pro 
                565                 570                 575     


Pro Leu 
        


<210>  4140
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  4140

Met Gly Arg Trp Ala Leu Asp Val Ala Phe Leu Trp Lys Ala Val Leu 
1               5                   10                  15      


Thr Leu Gly Leu Val Leu Leu Tyr Tyr Cys Phe Ser Ile Gly Ile Thr 
            20                  25                  30          


Phe Tyr Asn Lys Trp Leu Thr Lys Ser Phe His Phe Pro Leu Phe Met 
        35                  40                  45              


Thr Met Leu His Leu Ala Val Ile Phe Leu Phe Ser Ala Leu Ser Arg 
    50                  55                  60                  


Ala Leu Val Gln Cys Ser Ser His Arg Ala Arg Val Val Leu Ser Trp 
65                  70                  75                  80  


Ala Asp Tyr Leu Arg Arg Val Ala Pro Thr Ala Leu Ala Thr Ala Leu 
                85                  90                  95      


Asp Val Gly Leu Ser Asn Trp Ser Phe Leu Tyr Val Thr Val Ser Leu 
            100                 105                 110         


Tyr Thr Met Thr Lys Ser Ser Ala Val Leu Phe Ile Leu Ile Phe Ser 
        115                 120                 125             


Leu Ile Phe Lys Leu Glu Glu Leu Arg Ala Ala Leu Val Leu Val Val 
    130                 135                 140                 


Leu Leu Ile Ala Gly Gly Leu Phe Met Phe Thr Tyr Lys Ser Thr Gln 
145                 150                 155                 160 


Phe Asn Val Glu Gly Phe Ala Leu Val Leu Gly Ala Ser Phe Ile Gly 
                165                 170                 175     


Gly Ile Arg Trp Thr Leu Thr Gln Met Leu Leu Gln Lys Ala Glu Leu 
            180                 185                 190         


Gly Leu Gln Asn Pro Ile Asp Thr Met Phe His Leu Gln Pro Leu Met 
        195                 200                 205             


Phe Leu Gly Leu Phe Pro Leu Phe Ala Val Phe Glu Gly Leu His Leu 
    210                 215                 220                 


Ser Thr Ser Glu Lys Ile Phe Arg Phe Gln Asp Thr Gly Leu Leu Leu 
225                 230                 235                 240 


Arg Val Leu Gly Ser Leu Phe Leu Gly Gly Ile Leu Ala Phe Gly Leu 
                245                 250                 255     


Gly Phe Ser Glu Phe Leu Leu Val Ser Arg Thr Ser Ser Leu Thr Leu 
            260                 265                 270         


Ser Ile Ala Gly Ile Phe Lys Glu Val Cys Thr Leu Leu Leu Ala Ala 
        275                 280                 285             


His Leu Leu Gly Asp Gln Ile Ser Leu Leu Asn Trp Leu Gly Phe Ala 
    290                 295                 300                 


Leu Cys Leu Ser Gly Ile Ser Leu His Val Ala Leu Lys Ala Leu His 
305                 310                 315                 320 


Ser Arg Gly Asp Gly Gly Pro Lys Ala Leu Lys Gly Leu Gly Ser Ser 
                325                 330                 335     


Pro Asp Leu Glu Leu Leu Leu Arg Ser Ser Gln Arg Glu Glu Gly Asp 
            340                 345                 350         


Asn Glu Glu Glu Glu Tyr Phe Val Ala Gln Gly Gln Gln 
        355                 360                 365 


<210>  4141
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  4141

Met Asp Leu Thr Gln Gln Ala Lys Asp Ile Gln Asn Ile Thr Val Gln 
1               5                   10                  15      


Glu Thr Asn Lys Asn Asn Ser Glu Ser Ile Glu Cys Ser Lys Ile Thr 
            20                  25                  30          


Met Asp Leu Lys Phe Asn Asn Ser Arg Lys Tyr Ile Ser Ile Thr Val 
        35                  40                  45              


Pro Ser Lys Thr Gln Thr Met Ser Pro His Ile Lys Ser Val Asp Asp 
    50                  55                  60                  


Val Val Val Leu Gly Met Asn Leu Ser Lys Phe Asn Lys Leu Thr Gln 
65                  70                  75                  80  


Phe Phe Ile Cys Val Ala Gly Val Phe Val Phe Tyr Leu Ile Tyr Gly 
                85                  90                  95      


Tyr Leu Gln Glu Leu Ile Phe Ser Val Glu Gly Phe Lys Ser Cys Gly 
            100                 105                 110         


Trp Tyr Leu Thr Leu Val Gln Phe Ala Phe Tyr Ser Ile Phe Gly Leu 
        115                 120                 125             


Ile Glu Leu Gln Leu Ile Gln Asp Lys Arg Arg Arg Ile Pro Gly Lys 
    130                 135                 140                 


Thr Tyr Met Ile Ile Ala Phe Leu Thr Val Gly Thr Met Gly Leu Ser 
145                 150                 155                 160 


Asn Thr Ser Leu Gly Tyr Leu Asn Tyr Pro Thr Gln Val Ile Phe Lys 
                165                 170                 175     


Cys Cys Lys Leu Ile Pro Val Met Leu Gly Gly Val Phe Ile Gln Gly 
            180                 185                 190         


Lys Arg Tyr Asn Val Ala Asp Val Ser Ala Ala Ile Cys Met Ser Leu 
        195                 200                 205             


Gly Leu Ile Trp Phe Thr Leu Ala Asp Ser Thr Thr Ala Pro Asn Phe 
    210                 215                 220                 


Asn Leu Thr Gly Val Val Leu Ile Ser Leu Ala Leu Cys Ala Asp Ala 
225                 230                 235                 240 


Val Ile Gly Asn Val Gln Glu Lys Ala Met Lys Leu His Asn Ala Ser 
                245                 250                 255     


Asn Ser Glu Met Val Leu Tyr Ser Tyr Ser Ile Gly Phe Val Tyr Ile 
            260                 265                 270         


Leu Leu Gly Leu Thr Cys Thr Ser Gly Leu Gly Pro Ala Val Thr Phe 
        275                 280                 285             


Cys Ala Lys Asn Pro Val Arg Thr Tyr Gly Tyr Ala Phe Leu Phe Ser 
    290                 295                 300                 


Leu Thr Gly Tyr Phe Gly Ile Ser Phe Val Leu Ala Leu Ile Lys Ile 
305                 310                 315                 320 


Phe Gly Ala Leu Ile Ala Val Thr Val Thr Thr Gly Arg Lys Ala Met 
                325                 330                 335     


Thr Ile Val Leu Ser Phe Ile Phe Phe Ala Lys Pro Phe Thr Phe Gln 
            340                 345                 350         


Tyr Val Trp Ser Gly Leu Leu Val Val Leu Gly Ile Phe Leu Asn Val 
        355                 360                 365             


Tyr Ser Lys Asn Met Asp Lys Ile Arg Leu Pro Ser Leu Tyr Asp Leu 
    370                 375                 380                 


Ile Asn Lys Ser Val Glu Ala Arg Lys Ser Arg Thr Leu Ala Gln Thr 
385                 390                 395                 400 


Val 
    


<210>  4142
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  4142

Met Ala Val Leu Ala Pro Leu Ile Ala Leu Val Tyr Ser Val Pro Arg 
1               5                   10                  15      


Leu Ser Arg Trp Leu Ala Gln Pro Tyr Tyr Leu Leu Ser Ala Leu Leu 
            20                  25                  30          


Ser Ala Ala Phe Leu Leu Val Arg Lys Leu Pro Pro Leu Cys His Gly 
        35                  40                  45              


Leu Pro Thr Gln Arg Glu Asp Gly Asn Pro Cys Asp Phe Asp Trp Arg 
    50                  55                  60                  


Glu Val Glu Ile Leu Met Phe Leu Ser Ala Ile Val Met Met Lys Asn 
65                  70                  75                  80  


Arg Arg Ser Ile Thr Val Glu Gln His Ile Gly Asn Ile Phe Met Phe 
                85                  90                  95      


Ser Lys Val Ala Asn Thr Ile Leu Phe Phe Arg Leu Asp Ile Arg Met 
            100                 105                 110         


Gly Leu Leu Tyr Ile Thr Leu Cys Ile Val Phe Leu Met Thr Cys Lys 
        115                 120                 125             


Pro Pro Leu Tyr Met Gly Pro Glu Tyr Ile Lys Tyr Phe Asn Asp Lys 
    130                 135                 140                 


Thr Ile Asp Glu Glu Leu Glu Arg Asp Lys Arg Val Thr Trp Ile Val 
145                 150                 155                 160 


Glu Phe Phe Ala Asn Trp Ser Asn Asp Cys Gln Ser Phe Ala Pro Ile 
                165                 170                 175     


Tyr Ala Asp Leu Ser Leu Lys Tyr Asn Cys Thr Gly Leu Asn Phe Gly 
            180                 185                 190         


Lys Val Asp Val Gly Arg Tyr Thr Asp Val Ser Thr Arg Tyr Lys Val 
        195                 200                 205             


Ser Thr Ser Pro Leu Thr Lys Gln Leu Pro Thr Leu Ile Leu Phe Gln 
    210                 215                 220                 


Gly Gly Lys Glu Ala Met Arg Arg Pro Gln Ile Asp Lys Lys Gly Arg 
225                 230                 235                 240 


Ala Val Ser Trp Thr Phe Ser Glu Glu Asn Val Ile Arg Glu Phe Asn 
                245                 250                 255     


Leu Asn Glu Leu Tyr Gln Arg Ala Lys Lys Leu Ser Lys Ala Gly Asp 
            260                 265                 270         


Asn Ile Pro Glu Glu Gln Pro Val Ala Ser Thr Pro Thr Thr Val Ser 
        275                 280                 285             


Asp Gly Glu Asn Lys Lys Asp Lys 
    290                 295     


<210>  4143
<211>  27
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be any naturally occurring amino acid

<400>  4143

Ala Leu Pro His Ala Ser Asx Cys Met Pro Leu Glu Xaa Ser Asx Asn 
1               5                   10                  15      


Ile Thr His Met Ser Ala Pro Ile Glu Asn Ser 
            20                  25          


<210>  4144
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  4144

Met Glu Ala Leu Gly Lys Leu Lys Gln Phe Asp Ala Tyr Pro Lys Thr 
1               5                   10                  15      


Leu Glu Asp Phe Arg Val Lys Thr Cys Gly Gly Ala Thr Val Thr Ile 
            20                  25                  30          


Val Ser Gly Leu Leu Met Leu Leu Leu Phe Leu Ser Glu Leu Gln Tyr 
        35                  40                  45              


Tyr Leu Thr Thr Glu Val His Pro Glu Leu Tyr Val Asp Lys Ser Arg 
    50                  55                  60                  


Gly Asp Lys Leu Lys Ile Asn Ile Asp Val Leu Phe Pro His Met Pro 
65                  70                  75                  80  


Cys Ala Tyr Leu Ser Ile Asp Ala Met Asp Val Ala Gly Glu Gln Gln 
                85                  90                  95      


Leu Asp Val Glu His Asn Leu Phe Lys Gln Arg Leu Asp Lys Asp Gly 
            100                 105                 110         


Ile Pro Val Ser Ser Glu Ala Glu Arg His Glu Leu Gly Lys Val Glu 
        115                 120                 125             


Val Thr Val Phe Asp Pro Asp Ser Leu Asp Pro Asp Arg Cys Glu Ser 
    130                 135                 140                 


Cys Tyr Gly Ala Glu Ala Glu Asp Ile Lys Cys Cys Asn Thr Cys Glu 
145                 150                 155                 160 


Asp Val Arg Glu Ala Tyr Arg Arg Arg Gly Trp Ala Phe Lys Asn Pro 
                165                 170                 175     


Asp Thr Ile Glu Gln Cys Arg Arg Glu Gly Phe Ser Gln Lys Met Gln 
            180                 185                 190         


Glu Gln Lys Asn Glu Gly Cys Gln Val Tyr Gly Phe Leu Glu Val Asn 
        195                 200                 205             


Lys Val Ala Gly Asn Phe His Phe Ala Pro Gly Lys Ser Phe Gln Gln 
    210                 215                 220                 


Ser His Val His Val His Asp Leu Gln Ser Phe Gly Leu Asp Asn Ile 
225                 230                 235                 240 


Asn Met Thr His Tyr Ile Gln His Leu Ser Phe Gly Glu Asp Tyr Pro 
                245                 250                 255     


Gly Ile Val Asn Pro Leu Asp His Thr Asn Val Thr Ala Pro Gln Ala 
            260                 265                 270         


Ser Met Met Phe Gln Tyr Phe Val Lys Val Val Pro Thr Val Tyr Met 
        275                 280                 285             


Lys Val Asp Gly Glu Val Leu Arg Thr Asn Gln Phe Ser Val Thr Arg 
    290                 295                 300                 


His Glu Lys Val Ala Asn Gly Leu Leu Gly Asp Gln Gly Leu Pro Gly 
305                 310                 315                 320 


Val Phe Val Leu Tyr Glu Leu Ser Pro Met Met Val Lys Leu Thr Glu 
                325                 330                 335     


Lys His Arg Ser Phe Thr His Phe Leu Thr Gly Val Cys Ala Ile Ile 
            340                 345                 350         


Gly Gly Met Phe Thr Val Ala Gly Leu Ile Asp Ser Leu Ile Tyr His 
        355                 360                 365             


Ser Ala Arg Ala Ile Gln Lys Lys Ile Asp Leu Gly Lys Thr Thr 
    370                 375                 380             


<210>  4145
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  4145

Met Ala Arg Gly Ser Ala Leu Leu Leu Ala Ser Leu Leu Leu Ala Ala 
1               5                   10                  15      


Ala Leu Ser Ala Ser Ala Gly Leu Trp Ser Pro Ala Lys Glu Lys Arg 
            20                  25                  30          


Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Pro His Ala Val 
        35                  40                  45              


Gly Asn His Arg Ser Phe Ser Asp Lys Asn Gly Leu Thr Ser Lys Arg 
    50                  55                  60                  


Glu Leu Arg Pro Glu Asp Asp Met Lys Pro Gly Ser Phe Asp Arg Ser 
65                  70                  75                  80  


Ile Pro Glu Asn Asn Ile Met Arg Thr Ile Ile Glu Phe Leu Ser Phe 
                85                  90                  95      


Leu His Leu Lys Glu Ala Gly Ala Leu Asp Arg Leu Leu Asp Leu Pro 
            100                 105                 110         


Ala Ala Ala Ser Ser Glu Asp Ile Glu Arg Ser 
        115                 120             


<210>  4146
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  4146

Met Val Lys Leu Asn Ser Asn Pro Ser Glu Lys Gly Thr Lys Pro Pro 
1               5                   10                  15      


Ser Val Glu Asp Gly Phe Gln Thr Val Pro Leu Ile Thr Pro Leu Glu 
            20                  25                  30          


Val Asn His Leu Gln Leu Pro Ala Pro Glu Lys Val Ile Val Lys Thr 
        35                  40                  45              


Arg Thr Glu Tyr Gln Pro Glu Gln Lys Asn Lys Gly Lys Phe Arg Val 
    50                  55                  60                  


Pro Lys Ile Ala Glu Phe Thr Val Thr Ile Leu Val Ser Leu Ala Leu 
65                  70                  75                  80  


Ala Phe Leu Ala Cys Ile Val Phe Leu Val Val Tyr Lys Ala Phe Thr 
                85                  90                  95      


Tyr Asp His Ser Cys Pro Glu Gly Phe Val Tyr Lys His Lys Arg Cys 
            100                 105                 110         


Ile Pro Ala Ser Leu Asp Ala Tyr Tyr Ser Ser Gln Asp Pro Asn Ser 
        115                 120                 125             


Arg Ser Arg Phe Tyr Thr Val Ile Ser His Tyr Ser Val Ala Lys Gln 
    130                 135                 140                 


Ser Thr Ala Arg Ala Ile Gly Pro Trp Leu Ser Ala Ala Ala Val Ile 
145                 150                 155                 160 


His Glu Pro Lys Pro Pro Lys Thr Gln Gly His 
                165                 170     


<210>  4147
<211>  755
<212>  PRT
<213>  Homo sapiens

<400>  4147

Met Asn Val Ile Tyr Phe Pro Leu His Ile Phe Val Val Tyr Ser Arg 
1               5                   10                  15      


Ala Tyr Thr Ser Leu Val Leu Val Gly Cys Thr Asn Leu Cys Ala Val 
            20                  25                  30          


Leu Phe Ala Arg Cys Leu Asp Asp His Leu Val Ser Leu Arg Met Ser 
        35                  40                  45              


Gly Ser Arg Lys Glu Phe Asp Val Lys Gln Ile Leu Lys Ile Arg Trp 
    50                  55                  60                  


Arg Trp Phe Gly His Gln Ala Ser Ser Pro Asn Ser Thr Val Asp Ser 
65                  70                  75                  80  


Gln Gln Gly Glu Phe Trp Asn Arg Gly Gln Thr Gly Ala Asn Gly Gly 
                85                  90                  95      


Arg Lys Phe Leu Asp Pro Cys Ser Leu Gln Leu Pro Leu Ala Ser Ile 
            100                 105                 110         


Gly Tyr Arg Arg Ser Ser Gln Leu Asp Phe Gln Asn Ser Pro Ser Trp 
        115                 120                 125             


Pro Met Ala Ser Thr Ser Glu Val Pro Ala Phe Glu Phe Thr Ala Glu 
    130                 135                 140                 


Asp Cys Gly Gly Ala His Trp Leu Asp Arg Pro Glu Val Asp Asp Gly 
145                 150                 155                 160 


Thr Ser Glu Glu Glu Asn Glu Ser Asp Ser Ser Ser Cys Arg Thr Ser 
                165                 170                 175     


Asn Ser Ser Gln Thr Leu Ser Ser Cys His Thr Met Glu Pro Cys Thr 
            180                 185                 190         


Ser Asp Glu Phe Phe Gln Ala Leu Asn His Ala Glu Gln Thr Phe Lys 
        195                 200                 205             


Lys Met Glu Asn Tyr Leu Arg His Lys Gln Leu Cys Asp Val Ile Leu 
    210                 215                 220                 


Val Ala Gly Asp Arg Arg Ile Pro Ala His Arg Leu Val Leu Ser Ser 
225                 230                 235                 240 


Val Ser Asp Tyr Phe Ala Ala Met Phe Thr Asn Asp Val Arg Glu Ala 
                245                 250                 255     


Arg Gln Glu Glu Ile Lys Met Glu Gly Val Glu Pro Asn Ser Leu Trp 
            260                 265                 270         


Ser Leu Ile Gln Tyr Ala Tyr Thr Gly Arg Leu Glu Leu Lys Glu Asp 
        275                 280                 285             


Asn Ile Glu Cys Leu Leu Ser Thr Ala Cys Leu Leu Gln Leu Ser Gln 
    290                 295                 300                 


Val Val Glu Ala Cys Cys Lys Phe Leu Met Lys Gln Leu His Pro Ser 
305                 310                 315                 320 


Asn Cys Leu Gly Ile Arg Ser Phe Ala Asp Ala Gln Gly Cys Thr Asp 
                325                 330                 335     


Leu His Lys Val Ala His Asn Tyr Thr Met Glu His Phe Met Glu Val 
            340                 345                 350         


Ile Arg Asn Gln Glu Phe Val Leu Leu Pro Ala Ser Glu Ile Ala Lys 
        355                 360                 365             


Leu Leu Ala Ser Asp Asp Met Asn Ile Pro Asn Glu Glu Thr Ile Leu 
    370                 375                 380                 


Asn Ala Leu Leu Thr Trp Val Arg His Asp Leu Glu Gln Arg Arg Lys 
385                 390                 395                 400 


Asp Leu Ser Lys Leu Leu Ala Tyr Ile Arg Leu Pro Leu Leu Ala Pro 
                405                 410                 415     


Gln Phe Leu Ala Asp Met Glu Asn Asn Val Leu Phe Arg Asp Asp Ile 
            420                 425                 430         


Glu Cys Gln Lys Leu Ile Met Glu Ala Met Lys Tyr His Leu Leu Pro 
        435                 440                 445             


Glu Arg Arg Pro Met Leu Gln Ser Pro Arg Thr Lys Pro Arg Lys Ser 
    450                 455                 460                 


Thr Val Gly Thr Leu Phe Ala Val Gly Gly Met Asp Ser Thr Lys Gly 
465                 470                 475                 480 


Ala Thr Ser Ile Glu Lys Tyr Asp Leu Arg Thr Asn Met Trp Thr Pro 
                485                 490                 495     


Val Ala Asn Met Asn Gly Arg Arg Leu Gln Phe Gly Val Ala Val Leu 
            500                 505                 510         


Asp Asp Lys Leu Tyr Val Val Gly Gly Arg Asp Gly Leu Lys Thr Leu 
        515                 520                 525             


Asn Thr Val Glu Cys Tyr Asn Pro Lys Thr Lys Thr Trp Ser Val Met 
    530                 535                 540                 


Pro Pro Met Ser Thr His Arg His Gly Leu Gly Val Ala Val Leu Glu 
545                 550                 555                 560 


Gly Pro Met Tyr Ala Val Gly Gly His Asp Gly Trp Ser Tyr Leu Asn 
                565                 570                 575     


Thr Val Glu Arg Trp Asp Pro Gln Ala Arg Gln Trp Asn Phe Val Ala 
            580                 585                 590         


Thr Met Ser Thr Pro Arg Ser Thr Val Gly Val Ala Val Leu Ser Gly 
        595                 600                 605             


Lys Leu Tyr Ala Val Gly Gly Arg Asp Gly Ser Ser Cys Leu Lys Ser 
    610                 615                 620                 


Val Glu Cys Phe Asp Pro His Thr Asn Lys Trp Thr Leu Cys Ala Gln 
625                 630                 635                 640 


Met Ser Lys Arg Arg Gly Gly Val Gly Val Thr Thr Trp Asn Gly Leu 
                645                 650                 655     


Leu Tyr Ala Ile Gly Gly His Asp Ala Pro Ala Ser Asn Leu Thr Ser 
            660                 665                 670         


Arg Leu Ser Asp Cys Val Glu Arg Tyr Asp Pro Lys Thr Asp Met Trp 
        675                 680                 685             


Thr Ala Val Ala Ser Met Ser Ile Ser Arg Asp Ala Val Gly Val Cys 
    690                 695                 700                 


Leu Leu Gly Asp Lys Leu Tyr Ala Val Gly Gly Tyr Asp Gly Gln Ala 
705                 710                 715                 720 


Tyr Leu Asn Thr Val Glu Ala Tyr Asp Pro Gln Thr Asn Glu Trp Thr 
                725                 730                 735     


Gln Val Ala Pro Leu Cys Leu Gly Arg Ala Gly Ala Cys Val Val Thr 
            740                 745                 750         


Val Lys Leu 
        755 


<210>  4148
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  4148

Met Ala Glu Phe Pro Ser Lys Val Ser Thr Arg Thr Ser Ser Pro Ala 
1               5                   10                  15      


Gln Gly Ala Glu Ala Ser Val Ser Ala Leu Arg Pro Asp Leu Gly Phe 
            20                  25                  30          


Val Arg Ser Arg Leu Gly Ala Leu Met Leu Leu Gln Leu Val Leu Gly 
        35                  40                  45              


Leu Leu Val Trp Ala Leu Ile Ala Asp Thr Pro Tyr His Leu Tyr Pro 
    50                  55                  60                  


Ala Tyr Gly Trp Val Met Phe Val Ala Val Phe Leu Trp Leu Val Thr 
65                  70                  75                  80  


Ile Val Leu Phe Asn Leu Tyr Leu Phe Gln Leu His Met Lys Leu Tyr 
                85                  90                  95      


Met Val Pro Trp Pro Leu Val Leu Met Ile Phe Asn Ile Ser Ala Thr 
            100                 105                 110         


Val Leu Tyr Ile Thr Ala Phe Ile Ala Cys Ser Ala Ala Val Asp Leu 
        115                 120                 125             


Thr Ser Leu Arg Gly Thr Arg Pro Tyr Asn Gln Arg Ala Ala Ala Ser 
    130                 135                 140                 


Phe Phe Ala Cys Leu Val Met Ile Ala Tyr Gly Val Ser Ala Phe Phe 
145                 150                 155                 160 


Ser Tyr Gln Ala Trp Arg Gly Val Gly Ser Asn Ala Ala Thr Ser Gln 
                165                 170                 175     


Met Ala Gly Gly Tyr Ala 
            180         


<210>  4149
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  4149

Met Ser Ser His Lys Gly Ser Val Val Ala Gln Gly Asn Gly Ala Pro 
1               5                   10                  15      


Ala Ser Asn Arg Glu Ala Asp Thr Val Glu Leu Ala Glu Leu Gly Pro 
            20                  25                  30          


Leu Leu Glu Glu Lys Gly Lys Arg Val Ile Ala Asn Pro Pro Lys Ala 
        35                  40                  45              


Glu Glu Glu Gln Thr Cys Pro Val Pro Gln Glu Glu Glu Glu Glu Val 
    50                  55                  60                  


Arg Val Leu Thr Leu Pro Leu Gln Ala His His Ala Met Glu Lys Met 
65                  70                  75                  80  


Glu Glu Phe Val Tyr Lys Val Trp Glu Gly Arg Trp Arg Val Ile Pro 
                85                  90                  95      


Tyr Asp Val Leu Pro Asp Trp Leu Lys Asp Asn Asp Tyr Leu Leu His 
            100                 105                 110         


Gly His Arg Pro Pro Met Pro Ser Phe Arg Ala Cys Phe Lys Ser Ile 
        115                 120                 125             


Phe Arg Ile His Thr Glu Thr Gly Asn Ile Trp Thr His Leu Leu Gly 
    130                 135                 140                 


Phe Val Leu Phe Leu Phe Leu Gly Ile Leu Thr Met Leu Arg Pro Asn 
145                 150                 155                 160 


Met Tyr Phe Met Ala Pro Leu Gln Glu Lys Val Val Phe Gly Met Phe 
                165                 170                 175     


Phe Leu Gly Ala Val Leu Cys Leu Ser Phe Ser Trp Leu Phe His Thr 
            180                 185                 190         


Val Tyr Cys His Ser Glu Lys Val Ser Arg Thr Phe Ser Lys Leu Asp 
        195                 200                 205             


Tyr Ser Gly Ile Ala Leu Leu Ile Met Gly Ser Phe Val Pro Trp Leu 
    210                 215                 220                 


Tyr Tyr Ser Phe Tyr Cys Ser Pro Gln Pro Arg Leu Ile Tyr Leu Ser 
225                 230                 235                 240 


Ile Val Cys Val Leu Gly Ile Ser Ala Ile Ile Val Ala Gln Trp Asp 
                245                 250                 255     


Arg Phe Ala Thr Pro Lys His Arg Gln Thr Arg Ala Gly Val Phe Leu 
            260                 265                 270         


Gly Leu Gly Leu Ser Gly Val Val Pro Thr Met His Phe Thr Ile Ala 
        275                 280                 285             


Glu Gly Phe Val Lys Ala Thr Thr Val Gly Gln Met Gly Trp Phe Phe 
    290                 295                 300                 


Leu Met Ala Val Met Tyr Ile Thr Gly Ala Gly Leu Tyr Ala Ala Arg 
305                 310                 315                 320 


Ile Pro Glu Arg Phe Phe Pro Gly Lys Phe Asp Ile Trp Phe Gln Ser 
                325                 330                 335     


His Gln Ile Phe His Val Leu Val Val Ala Ala Ala Phe Val His Phe 
            340                 345                 350         


Tyr Gly Val Ser Asn Leu Gln Glu Phe Arg Tyr Gly Leu Glu Gly Gly 
        355                 360                 365             


Cys Thr Asp Asp Thr Leu Leu 
    370                 375 


<210>  4150
<211>  429
<212>  PRT
<213>  Homo sapiens

<400>  4150

Met Ala Thr Glu Gln Arg Pro Phe His Leu Val Val Phe Gly Ala Ser 
1               5                   10                  15      


Gly Phe Thr Gly Gln Phe Val Thr Glu Glu Val Ala Arg Glu Gln Val 
            20                  25                  30          


Asp Pro Glu Arg Ser Ser Arg Leu Pro Trp Ala Val Ala Gly Arg Ser 
        35                  40                  45              


Arg Glu Lys Leu Gln Arg Val Leu Glu Lys Ala Ala Leu Lys Leu Gly 
    50                  55                  60                  


Arg Pro Thr Leu Ser Ser Glu Val Gly Ile Ile Ile Cys Asp Ile Ala 
65                  70                  75                  80  


Asn Pro Ala Ser Leu Asp Glu Met Ala Lys Gln Ala Thr Val Val Leu 
                85                  90                  95      


Asn Cys Val Gly Pro Tyr Arg Phe Tyr Gly Glu Pro Val Ile Lys Ala 
            100                 105                 110         


Cys Ile Glu Asn Gly Ala Ser Cys Ile Asp Ile Ser Gly Glu Pro Gln 
        115                 120                 125             


Phe Leu Glu Leu Met Gln Leu Lys Tyr His Glu Lys Ala Ala Asp Lys 
    130                 135                 140                 


Gly Val Tyr Ile Ile Gly Ser Ser Gly Phe Asp Ser Ile Pro Ala Asp 
145                 150                 155                 160 


Leu Gly Val Ile Tyr Thr Arg Asn Lys Met Asn Gly Thr Leu Thr Ala 
                165                 170                 175     


Val Glu Ser Phe Leu Thr Ile His Ser Gly Pro Glu Gly Leu Ser Ile 
            180                 185                 190         


His Asp Gly Thr Trp Lys Ser Ala Ile Tyr Gly Phe Gly Asp Gln Ser 
        195                 200                 205             


Asn Leu Arg Lys Leu Arg Asn Val Ser Asn Leu Lys Pro Val Pro Leu 
    210                 215                 220                 


Ile Gly Pro Lys Leu Lys Arg Arg Trp Pro Ile Ser Tyr Cys Arg Glu 
225                 230                 235                 240 


Leu Lys Gly Tyr Ser Ile Pro Phe Met Gly Ser Asp Val Ser Val Val 
                245                 250                 255     


Arg Arg Thr Gln Arg Tyr Leu Tyr Glu Asn Leu Glu Glu Ser Pro Val 
            260                 265                 270         


Gln Tyr Ala Ala Tyr Val Thr Val Gly Gly Ile Thr Ser Val Ile Lys 
        275                 280                 285             


Leu Met Phe Ala Gly Leu Phe Phe Leu Phe Phe Val Arg Phe Gly Ile 
    290                 295                 300                 


Gly Arg Gln Leu Leu Ile Lys Phe Pro Trp Phe Phe Ser Phe Gly Tyr 
305                 310                 315                 320 


Phe Ser Lys Gln Gly Pro Thr Gln Lys Gln Ile Asp Ala Ala Ser Phe 
                325                 330                 335     


Thr Leu Thr Phe Phe Gly Gln Gly Tyr Ser Gln Gly Thr Gly Thr Asp 
            340                 345                 350         


Lys Asn Lys Pro Asn Ile Lys Ile Cys Thr Gln Val Lys Gly Pro Glu 
        355                 360                 365             


Ala Gly Tyr Val Ala Thr Pro Ile Ala Met Val Gln Ala Ala Met Thr 
    370                 375                 380                 


Leu Leu Ser Asp Ala Ser His Leu Pro Lys Ala Gly Gly Val Phe Thr 
385                 390                 395                 400 


Pro Gly Ala Ala Phe Ser Lys Thr Lys Leu Ile Asp Arg Leu Asn Lys 
                405                 410                 415     


His Gly Ile Glu Phe Ser Val Ile Ser Ser Ser Glu Val 
            420                 425                 


<210>  4151
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  4151

Met Ala Asp Gln Asp Pro Ala Gly Ile Ser Pro Leu Gln Gln Met Val 
1               5                   10                  15      


Ala Ser Gly Thr Gly Ala Val Val Thr Ser Leu Phe Met Thr Pro Leu 
            20                  25                  30          


Asp Val Val Lys Val Arg Leu Gln Ser Gln Arg Pro Ser Met Ala Ser 
        35                  40                  45              


Glu Leu Met Pro Ser Ser Arg Leu Trp Ser Leu Ser Tyr Thr Lys Trp 
    50                  55                  60                  


Lys Cys Leu Leu Tyr Cys Asn Gly Val Leu Glu Pro Leu Tyr Leu Cys 
65                  70                  75                  80  


Pro Asn Gly Ala Arg Cys Ala Thr Trp Phe Gln Asp Pro Thr Arg Phe 
                85                  90                  95      


Thr Gly Thr Met Asp Ala Phe Val Lys Ile Val Arg His Glu Gly Thr 
            100                 105                 110         


Arg Thr Leu Trp Ser Gly Leu Pro Ala Thr Leu Val Met Thr Val Pro 
        115                 120                 125             


Ala Thr Ala Ile Tyr Phe Thr Ala Tyr Asp Gln Leu Lys Ala Phe Leu 
    130                 135                 140                 


Cys Gly Arg Ala Leu Thr Ser Asp Leu Tyr Ala Pro Met Val Ala Gly 
145                 150                 155                 160 


Ala Leu Ala Arg Leu Gly Thr Val Thr Val Ile Ser Pro Leu Glu Leu 
                165                 170                 175     


Met Arg Thr Lys Leu Gln Ala Gln His Val Ser Tyr Arg Glu Leu Gly 
            180                 185                 190         


Ala Cys Val Arg Thr Ala Val Ala Gln Gly Gly Trp Arg Ser Leu Trp 
        195                 200                 205             


Leu Gly Trp Gly Pro Thr Ala Leu Arg Asp Val Pro Phe Ser Ala Leu 
    210                 215                 220                 


Tyr Trp Phe Asn Tyr Glu Leu Val Lys Ser Trp Leu Asn Gly Phe Arg 
225                 230                 235                 240 


Pro Lys Asp Gln Thr Ser Val Gly Met Ser Phe Val Ala Gly Gly Ile 
                245                 250                 255     


Ser Gly Thr Val Ala Ala Val Leu Thr Leu Pro Phe Asp Val Val Lys 
            260                 265                 270         


Thr Gln Arg Gln Val Ala Leu Gly Ala Met Glu Ala Val Arg Val Asn 
        275                 280                 285             


Pro Leu His Val Asp Ser Thr Trp Leu Leu Leu Arg Arg Ile Arg Ala 
    290                 295                 300                 


Glu Ser Gly Thr Lys Gly Leu Phe Ala Gly Phe Leu Pro Arg Ile Ile 
305                 310                 315                 320 


Lys Ala Ala Pro Ser Cys Ala Ile Met Ile Ser Thr Tyr Glu Phe Gly 
                325                 330                 335     


Lys Ser Phe Phe Gln Arg Leu Asn Gln Asp Arg Leu Leu Gly Gly 
            340                 345                 350     


<210>  4152
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  4152

Met Glu Thr Arg Tyr Asn Leu Lys Ser Pro Ala Val Lys Arg Leu Met 
1               5                   10                  15      


Lys Glu Ala Ala Glu Leu Lys Asp Pro Thr Asp His Tyr His Ala Gln 
            20                  25                  30          


Pro Leu Glu Asp Asn Leu Phe Glu Trp His Phe Thr Val Arg Gly Pro 
        35                  40                  45              


Pro Asp Ser Asp Phe Asp Gly Gly Val Tyr His Gly Arg Ile Val Leu 
    50                  55                  60                  


Pro Pro Glu Tyr Pro Met Lys Pro Pro Ser Ile Ile Leu Leu Thr Ala 
65                  70                  75                  80  


Asn Gly Arg Phe Glu Val Gly Lys Lys Ile Cys Leu Ser Ile Ser Gly 
                85                  90                  95      


His His Pro Glu Thr Trp Gln Pro Ser Trp Ser Ile Arg Thr Ala Leu 
            100                 105                 110         


Leu Ala Ile Ile Gly Phe Met Pro Thr Lys Gly Glu Gly Ala Ile Gly 
        115                 120                 125             


Ser Leu Asp Tyr Thr Pro Glu Glu Arg Arg Ala Leu Ala Lys Lys Ser 
    130                 135                 140                 


Gln Asp Phe Cys Cys Glu Gly Cys Gly Ser Ala Met Lys Asp Val Leu 
145                 150                 155                 160 


Leu Pro Leu Lys Ser Gly Ser Asp Ser Ser Gln Ala Asp Gln Glu Ala 
                165                 170                 175     


Lys Glu Leu Ala Arg Gln Ile Ser Phe Lys Ala Glu Val Asn Ser Ser 
            180                 185                 190         


Gly Lys Thr Ile Ser Glu Ser Asp Leu Asn His Ser Phe Ser Leu Thr 
        195                 200                 205             


Asp Leu Gln Asp Asp Ile Pro Thr Thr Phe Gln Gly Ala Thr Ala Ser 
    210                 215                 220                 


Thr Ser Tyr Gly Leu Gln Asn Ser Ser Ala Ala Ser Phe His Gln Pro 
225                 230                 235                 240 


Thr Gln Pro Val Ala Lys Asn Thr Ser Met Ser Pro Arg Gln Arg Arg 
                245                 250                 255     


Ala Gln Gln Gln Ser Gln Arg Arg Leu Ser Thr Ser Pro Asp Val Ile 
            260                 265                 270         


Gln Gly His Gln Pro Arg Asp Asn His Thr Asp His Gly Gly Ser Ala 
        275                 280                 285             


Val Leu Ile Val Ile Leu Thr Leu Ala Leu Ala Ala Leu Ile Phe Arg 
    290                 295                 300                 


Arg Ile Tyr Leu Ala Asn Glu Tyr Ile Phe Asp Phe Glu Leu 
305                 310                 315             


<210>  4153
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  4153

Met Gly Ala Ala Val Phe Phe Gly Cys Thr Phe Val Ala Phe Gly Pro 
1               5                   10                  15      


Ala Phe Ala Leu Phe Leu Ile Thr Val Ala Gly Asp Pro Leu Arg Val 
            20                  25                  30          


Ile Ile Leu Val Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Leu 
        35                  40                  45              


Ala Ser Val Val Trp Phe Ile Leu Val His Val Thr Asp Arg Ser Asp 
    50                  55                  60                  


Ala Arg Leu Gln Tyr Gly Leu Leu Ile Phe Gly Ala Ala Val Ser Val 
65                  70                  75                  80  


Leu Leu Gln Glu Val Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Asp Glu Gly Leu Ala Ser Leu Ser Glu Asp Gly Arg Ser Pro Ile 
            100                 105                 110         


Ser Ile Arg Gln Met Ala Tyr Val Ser Gly Leu Ser Phe Gly Ile Ile 
        115                 120                 125             


Ser Gly Val Phe Ser Val Ile Asn Ile Leu Ala Asp Ala Leu Gly Pro 
    130                 135                 140                 


Gly Val Val Gly Ile His Gly Asp Ser Pro Tyr Tyr Phe Leu Thr Ser 
145                 150                 155                 160 


Ala Phe Leu Thr Ala Ala Ile Ile Leu Leu His Thr Phe Trp Gly Val 
                165                 170                 175     


Val Phe Phe Asp Ala Cys Glu Arg Arg Arg Tyr Trp Ala Leu Gly Leu 
            180                 185                 190         


Val Val Gly Ser His Leu Leu Thr Ser Gly Leu Thr Phe Leu Asn Pro 
        195                 200                 205             


Trp Tyr Glu Ala Ser Leu Leu Pro Ile Tyr Ala Val Thr Val Ser Met 
    210                 215                 220                 


Gly Leu Trp Ala Phe Ile Thr Ala Gly Gly Ser Leu Arg Ser Ile Gln 
225                 230                 235                 240 


Arg Ser Leu Leu Cys Lys Asp 
                245         


<210>  4154
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  4154

Met Val Glu Leu Met Phe Pro Leu Leu Leu Leu Leu Leu Pro Phe Leu 
1               5                   10                  15      


Leu Tyr Met Ala Ala Pro Gln Ile Arg Lys Met Leu Ser Ser Gly Val 
            20                  25                  30          


Cys Thr Ser Thr Val Gln Leu Pro Gly Lys Val Val Val Val Thr Gly 
        35                  40                  45              


Ala Asn Thr Gly Ile Gly Lys Glu Thr Ala Lys Glu Leu Ala Gln Arg 
    50                  55                  60                  


Gly Ala Arg Val Tyr Leu Ala Cys Arg Asp Val Glu Lys Gly Glu Leu 
65                  70                  75                  80  


Val Ala Lys Glu Ile Gln Thr Thr Thr Gly Asn Gln Gln Val Leu Val 
                85                  90                  95      


Arg Lys Leu Asp Leu Ser Asp Thr Lys Ser Ile Arg Ala Phe Ala Lys 
            100                 105                 110         


Gly Phe Leu Ala Glu Glu Lys His Leu His Val Leu Ile Asn Asn Ala 
        115                 120                 125             


Gly Val Met Met Cys Pro Tyr Ser Lys Thr Ala Asp Gly Phe Glu Met 
    130                 135                 140                 


His Ile Gly Val Asn His Leu Gly His Phe Leu Leu Thr His Leu Leu 
145                 150                 155                 160 


Leu Glu Lys Leu Lys Glu Ser Ala Pro Ser Arg Ile Val Asn Val Ser 
                165                 170                 175     


Ser Leu Ala His His Leu Gly Arg Ile His Phe His Asn Leu Gln Gly 
            180                 185                 190         


Glu Lys Phe Tyr Asn Ala Gly Leu Ala Tyr Cys His Ser Lys Leu Ala 
        195                 200                 205             


Asn Ile Leu Phe Thr Gln Glu Leu Ala Arg Arg Leu Lys Gly Ser Gly 
    210                 215                 220                 


Val Thr Thr Tyr Ser Val His Pro Gly Thr Val Gln Ser Glu Leu Val 
225                 230                 235                 240 


Arg His Ser Ser Phe Met Arg Trp Met Trp Trp Leu Phe Ser Phe Phe 
                245                 250                 255     


Ile Lys Thr Pro Gln Gln Gly Ala Gln Thr Ser Leu His Cys Ala Leu 
            260                 265                 270         


Thr Glu Gly Leu Glu Ile Leu Ser Gly Asn His Phe Ser Asp Cys His 
        275                 280                 285             


Val Ala Trp Val Ser Ala Gln Ala Arg Asn Glu Thr Ile Ala Arg Arg 
    290                 295                 300                 


Leu Trp Asp Val Ser Cys Asp Leu Leu Gly Leu Pro Ile Asp 
305                 310                 315             


<210>  4155
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  4155

Met Asn Trp Glu Leu Leu Leu Trp Leu Leu Val Leu Cys Ala Leu Leu 
1               5                   10                  15      


Leu Leu Leu Val Gln Leu Leu Arg Phe Leu Arg Ala Asp Gly Asp Leu 
            20                  25                  30          


Thr Leu Leu Trp Ala Glu Trp Gln Gly Arg Arg Pro Glu Trp Glu Leu 
        35                  40                  45              


Thr Asp Met Val Val Trp Val Thr Gly Ala Ser Ser Gly Ile Gly Glu 
    50                  55                  60                  


Glu Leu Ala Tyr Gln Leu Ser Lys Leu Gly Val Ser Leu Val Leu Ser 
65                  70                  75                  80  


Ala Arg Arg Val His Glu Leu Glu Arg Val Lys Arg Arg Cys Leu Glu 
                85                  90                  95      


Asn Gly Asn Leu Lys Glu Lys Asp Ile Leu Val Leu Pro Leu Asp Leu 
            100                 105                 110         


Thr Asp Thr Gly Ser His Glu Ala Ala Thr Lys Ala Val Leu Gln Glu 
        115                 120                 125             


Phe Gly Arg Ile Asp Ile Leu Val Asn Asn Gly Gly Met Ser Gln Arg 
    130                 135                 140                 


Ser Leu Cys Met Asp Thr Ser Leu Asp Val Tyr Arg Lys Leu Ile Glu 
145                 150                 155                 160 


Leu Asn Tyr Leu Gly Thr Val Ser Leu Thr Lys Cys Val Leu Pro His 
                165                 170                 175     


Met Ile Glu Arg Lys Gln Gly Lys Ile Val Thr Val Asn Ser Ile Leu 
            180                 185                 190         


Gly Ile Ile Ser Val Pro Leu Ser Ile Gly Tyr Cys Ala Ser Lys His 
        195                 200                 205             


Ala Leu Arg Gly Phe Phe Asn Gly Leu Arg Thr Glu Leu Ala Thr Tyr 
    210                 215                 220                 


Pro Gly Ile Ile Val Ser Asn Ile Cys Pro Gly Pro Val Gln Ser Asn 
225                 230                 235                 240 


Ile Val Glu Asn Ser Leu Ala Gly Glu Val Thr Lys Thr Ile Gly Asn 
                245                 250                 255     


Asn Gly Asp Gln Ser His Lys Met Thr Thr Ser Arg Cys Val Arg Leu 
            260                 265                 270         


Met Leu Ile Ser Met Ala Asn Asp Leu Lys Glu Val Trp Ile Ser Glu 
        275                 280                 285             


Gln Pro Phe Leu Leu Val Thr Tyr Leu Trp Gln Tyr Met Pro Thr Trp 
    290                 295                 300                 


Ala Trp Trp Ile Thr Asn Lys Met Gly Lys Lys Arg Ile Glu Asn Phe 
305                 310                 315                 320 


Lys Ser Gly Val Asp Ala Asp Ser Ser Tyr Phe Lys Ile Phe Lys Thr 
                325                 330                 335     


Lys His Asp 
            


<210>  4156
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  4156

Met Ser Val Met Val Val Arg Lys Lys Val Thr Arg Lys Trp Glu Lys 
1               5                   10                  15      


Leu Pro Gly Arg Asn Thr Phe Cys Cys Asp Gly Arg Val Met Met Ala 
            20                  25                  30          


Arg Gln Lys Gly Ile Phe Tyr Leu Thr Leu Phe Leu Ile Leu Gly Thr 
        35                  40                  45              


Cys Thr Leu Phe Phe Ala Phe Glu Cys Arg Tyr Leu Ala Val Gln Leu 
    50                  55                  60                  


Ser Pro Ala Ile Pro Val Phe Ala Ala Met Leu Phe Leu Phe Ser Met 
65                  70                  75                  80  


Ala Thr Leu Leu Arg Thr Ser Phe Ser Asp Pro Gly Val Ile Pro Arg 
                85                  90                  95      


Ala Leu Pro Asp Glu Ala Ala Phe Ile Glu Met Glu Ile Glu Ala Thr 
            100                 105                 110         


Asn Gly Ala Val Pro Gln Gly Gln Arg Pro Pro Pro Arg Ile Lys Asn 
        115                 120                 125             


Phe Gln Ile Asn Asn Gln Ile Val Lys Leu Lys Tyr Cys Tyr Thr Cys 
    130                 135                 140                 


Lys Ile Phe Arg Pro Pro Arg Ala Ser His Cys Ser Ile Cys Asp Asn 
145                 150                 155                 160 


Cys Val Glu Arg Phe Asp His His Cys Pro Trp Val Gly Asn Cys Val 
                165                 170                 175     


Gly Lys Arg Asn Tyr Arg Tyr Phe Tyr Leu Phe Ile Leu Ser Leu Ser 
            180                 185                 190         


Leu Leu Thr Ile Tyr Val Phe Ala Phe Asn Ile Val Tyr Val Ala Leu 
        195                 200                 205             


Lys Ser Leu Lys Ile Gly Phe Leu Glu Thr Leu Lys Glu Thr Pro Gly 
    210                 215                 220                 


Thr Val Leu Glu Val Leu Ile Cys Phe Phe Thr Leu Trp Ser Val Val 
225                 230                 235                 240 


Gly Leu Thr Gly Phe His Thr Phe Leu Val Ala Leu Asn Gln Thr Thr 
                245                 250                 255     


Asn Glu Asp Ile Lys Gly Ser Trp Thr Gly Lys Asn Arg Val Gln Asn 
            260                 265                 270         


Pro Tyr Ser His Gly Asn Ile Val Lys Asn Cys Cys Glu Val Leu Cys 
        275                 280                 285             


Gly Pro Leu Pro Pro Ser Val Leu Asp Arg Arg Gly Ile Leu Pro Leu 
    290                 295                 300                 


Glu Glu Ser Gly Ser Arg Pro Pro Ser Thr Gln Glu Thr Ser Ser Ser 
305                 310                 315                 320 


Leu Leu Pro Gln Ser Pro Ala Pro Thr Glu His Leu Asn Ser Asn Glu 
                325                 330                 335     


Met Pro Glu Asp Ser Ser Thr Pro Glu Glu Met Pro Pro Pro Glu Pro 
            340                 345                 350         


Pro Glu Pro Pro Gln Glu Ala Ala Glu Ala Glu Lys 
        355                 360                 


<210>  4157
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  4157

Met Gly Asp Lys Ile Trp Leu Pro Phe Pro Val Leu Leu Leu Ala Ala 
1               5                   10                  15      


Leu Pro Pro Val Leu Leu Pro Gly Ala Ala Gly Phe Thr Pro Ser Leu 
            20                  25                  30          


Asp Ser Asp Phe Thr Phe Thr Leu Pro Ala Gly Gln Lys Glu Cys Phe 
        35                  40                  45              


Tyr Gln Pro Met Pro Leu Lys Ala Ser Leu Glu Ile Glu Tyr Gln Val 
    50                  55                  60                  


Leu Asp Gly Ala Gly Leu Asp Ile Asp Phe His Leu Ala Ser Pro Glu 
65                  70                  75                  80  


Gly Lys Thr Leu Val Phe Glu Gln Arg Lys Ser Asp Gly Val His Thr 
                85                  90                  95      


Val Glu Thr Glu Val Gly Asp Tyr Met Phe Cys Phe Asp Asn Thr Phe 
            100                 105                 110         


Ser Thr Ile Ser Glu Lys Val Ile Phe Phe Glu Leu Ile Leu Asp Asn 
        115                 120                 125             


Met Gly Glu Gln Ala Gln Glu Gln Glu Asp Trp Lys Lys Tyr Ile Thr 
    130                 135                 140                 


Gly Thr Asp Ile Leu Asp Met Lys Leu Glu Asp Ile Leu Glu Ser Ile 
145                 150                 155                 160 


Asn Ser Ile Lys Ser Arg Leu Ser Lys Ser Gly His Ile Gln Thr Leu 
                165                 170                 175     


Leu Arg Ala Phe Glu Ala Arg Asp Arg Asn Ile Gln Glu Ser Asn Phe 
            180                 185                 190         


Asp Arg Val Asn Phe Trp Ser Met Val Asn Leu Val Val Met Val Val 
        195                 200                 205             


Val Ser Ala Ile Gln Val Tyr Met Leu Lys Ser Leu Phe Glu Asp Lys 
    210                 215                 220                 


Arg Lys Ser Arg Thr 
225                 


<210>  4158
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  4158

Met Ala Tyr Gln Ser Leu Arg Leu Glu Tyr Leu Gln Ile Pro Pro Val 
1               5                   10                  15      


Ser Arg Ala Tyr Thr Thr Ala Cys Val Leu Thr Thr Ala Ala Val Gln 
            20                  25                  30          


Leu Glu Leu Ile Thr Pro Phe Gln Leu Tyr Phe Asn Pro Glu Leu Ile 
        35                  40                  45              


Phe Lys His Phe Gln Ile Trp Arg Leu Ile Thr Asn Phe Leu Phe Phe 
    50                  55                  60                  


Gly Pro Val Gly Phe Asn Phe Leu Phe Asn Met Ile Phe Leu Tyr Arg 
65                  70                  75                  80  


Tyr Cys Arg Met Leu Glu Glu Gly Ser Phe Arg Gly Arg Thr Ala Asp 
                85                  90                  95      


Phe Val Phe Met Phe Leu Phe Gly Gly Phe Leu Met Thr Leu Phe Gly 
            100                 105                 110         


Leu Phe Val Ser Leu Val Phe Leu Gly Gln Ala Phe Thr Ile Met Leu 
        115                 120                 125             


Val Tyr Val Trp Ser Arg Arg Asn Pro Tyr Val Arg Met Asn Phe Phe 
    130                 135                 140                 


Gly Leu Leu Asn Phe Gln Ala Pro Phe Leu Pro Trp Val Leu Met Gly 
145                 150                 155                 160 


Phe Ser Leu Leu Leu Gly Asn Ser Ile Ile Val Asp Leu Leu Gly Ile 
                165                 170                 175     


Ala Val Gly His Ile Tyr Phe Phe Leu Glu Asp Val Phe Pro Asn Gln 
            180                 185                 190         


Pro Gly Gly Ile Arg Ile Leu Lys Thr Pro Ser Ile Leu Lys Ala Ile 
        195                 200                 205             


Phe Asp Thr Pro Asp Glu Asp Pro Asn Tyr Asn Pro Leu Pro Glu Glu 
    210                 215                 220                 


Arg Pro Gly Gly Phe Ala Trp Gly Glu Gly Gln Arg Leu Gly Gly 
225                 230                 235                 


<210>  4159
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  4159

Met Ala Asp Pro Asp Pro Arg Tyr Pro Arg Ser Ser Ile Glu Asp Asp 
1               5                   10                  15      


Phe Asn Tyr Gly Ser Ser Val Ala Ser Ala Thr Val His Ile Arg Met 
            20                  25                  30          


Ala Phe Leu Arg Lys Val Tyr Ser Ile Leu Ser Leu Gln Val Leu Leu 
        35                  40                  45              


Thr Thr Val Thr Ser Thr Val Phe Leu Tyr Phe Glu Ser Val Arg Thr 
    50                  55                  60                  


Phe Val His Glu Ser Pro Ala Leu Ile Leu Leu Phe Ala Leu Gly Ser 
65                  70                  75                  80  


Leu Gly Leu Ile Phe Ala Leu Ile Leu Asn Arg His Lys Tyr Pro Leu 
                85                  90                  95      


Asn Leu Tyr Leu Leu Phe Gly Phe Thr Leu Leu Glu Ala Leu Thr Val 
            100                 105                 110         


Ala Val Val Val Thr Phe Tyr Asp Val Tyr Ile Ile Leu Gln Ala Phe 
        115                 120                 125             


Ile Leu Thr Thr Thr Val Phe Phe Gly Leu Thr Val Tyr Thr Leu Gln 
    130                 135                 140                 


Ser Lys Lys Asp Phe Ser Lys Phe Gly Ala Gly Leu Phe Ala Leu Leu 
145                 150                 155                 160 


Trp Ile Leu Cys Leu Ser Gly Phe Leu Lys Phe Phe Phe Tyr Ser Glu 
                165                 170                 175     


Ile Met Glu Leu Val Leu Ala Ala Ala Gly Ala Leu Leu Phe Cys Gly 
            180                 185                 190         


Phe Ile Ile Tyr Asp Thr His Ser Leu Met His Lys Leu Ser Pro Glu 
        195                 200                 205             


Glu Tyr Val Leu Ala Ala Ile Ser Leu Tyr Leu Asp Ile Ile Asn Leu 
    210                 215                 220                 


Phe Leu His Leu Leu Arg Phe Leu Glu Ala Val Asn Lys Lys 
225                 230                 235             


<210>  4160
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  4160

Met Glu Ala Val Leu Asn Glu Leu Val Ser Val Glu Asp Leu Leu Lys 
1               5                   10                  15      


Phe Glu Lys Lys Phe Gln Ser Glu Lys Ala Ala Gly Ser Val Ser Lys 
            20                  25                  30          


Ser Thr Gln Phe Glu Tyr Ala Trp Cys Leu Val Arg Ser Lys Tyr Asn 
        35                  40                  45              


Asp Asp Ile Arg Lys Gly Ile Val Leu Leu Glu Glu Leu Leu Pro Lys 
    50                  55                  60                  


Gly Ser Lys Glu Glu Gln Arg Asp Tyr Val Phe Tyr Leu Ala Val Gly 
65                  70                  75                  80  


Asn Tyr Arg Leu Lys Glu Tyr Glu Lys Ala Leu Lys Tyr Val Arg Gly 
                85                  90                  95      


Leu Leu Gln Thr Glu Pro Gln Asn Asn Gln Ala Lys Glu Leu Glu Arg 
            100                 105                 110         


Leu Ile Asp Lys Ala Met Lys Lys Asp Gly Leu Val Gly Met Ala Ile 
        115                 120                 125             


Val Gly Gly Met Ala Leu Gly Val Ala Gly Leu Ala Gly Leu Ile Gly 
    130                 135                 140                 


Leu Ala Val Ser Lys Ser Lys Ser 
145                 150         


<210>  4161
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  4161

Met Ile Ser Leu Thr Asp Thr Gln Lys Ile Gly Met Gly Leu Thr Gly 
1               5                   10                  15      


Phe Gly Val Phe Phe Leu Phe Phe Gly Met Ile Leu Phe Phe Asp Lys 
            20                  25                  30          


Ala Leu Leu Ala Ile Gly Asn Val Leu Phe Val Ala Gly Leu Ala Phe 
        35                  40                  45              


Val Ile Gly Leu Glu Arg Thr Phe Arg Phe Phe Phe Gln Lys His Lys 
    50                  55                  60                  


Met Lys Ala Thr Gly Phe Phe Leu Gly Gly Val Phe Val Val Leu Ile 
65                  70                  75                  80  


Gly Trp Pro Leu Ile Gly Met Ile Phe Glu Ile Tyr Gly Phe Phe Leu 
                85                  90                  95      


Leu Phe Arg Gly Phe Phe Pro Val Val Val Gly Phe Ile Arg Arg Val 
            100                 105                 110         


Pro Val Leu Gly Ser Leu Leu Asn Leu Pro Gly Ile Arg Ser Phe Val 
        115                 120                 125             


Asp Lys Val Gly Glu Ser Asn Asn Met Val 
    130                 135             


<210>  4162
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  4162

Met Pro Ser Lys Ser Leu Val Met Glu Tyr Leu Ala His Pro Ser Thr 
1               5                   10                  15      


Leu Gly Leu Ala Val Gly Val Ala Cys Gly Met Cys Leu Gly Trp Ser 
            20                  25                  30          


Leu Arg Val Cys Phe Gly Met Leu Pro Lys Ser Lys Thr Ser Lys Thr 
        35                  40                  45              


His Thr Asp Thr Glu Ser Glu Ala Ser Ile Leu Gly Asp Ser Gly Glu 
    50                  55                  60                  


Tyr Lys Met Ile Leu Val Val Arg Asn Asp Leu Lys Met Gly Lys Gly 
65                  70                  75                  80  


Lys Val Ala Ala Gln Cys Ser His Ala Ala Val Ser Ala Tyr Lys Gln 
                85                  90                  95      


Ile Gln Arg Arg Asn Pro Glu Met Leu Lys Gln Trp Glu Tyr Cys Gly 
            100                 105                 110         


Gln Pro Lys Val Val Val Lys Ala Pro Asp Glu Glu Thr Leu Ile Ala 
        115                 120                 125             


Leu Leu Ala His Ala Lys Met Leu Gly Leu Thr Val Ser Leu Ile Gln 
    130                 135                 140                 


Asp Ala Gly Arg Thr Gln Ile Ala Pro Gly Ser Gln Thr Val Leu Gly 
145                 150                 155                 160 


Ile Gly Pro Gly Pro Ala Asp Leu Ile Asp Lys Val Thr Gly His Leu 
                165                 170                 175     


Lys Leu Tyr 
            


<210>  4163
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  4163

Met Leu Gln Gln Asp Ser Asn Asp Asp Thr Glu Asp Val Ser Leu Phe 
1               5                   10                  15      


Asp Ala Glu Glu Glu Thr Thr Asn Arg Pro Arg Lys Ala Lys Ile Arg 
            20                  25                  30          


His Pro Val Ala Ser Phe Phe His Leu Phe Phe Arg Val Ser Ala Ile 
        35                  40                  45              


Ile Val Tyr Leu Leu Cys Gly Leu Leu Ser Ser Ser Phe Ile Thr Cys 
    50                  55                  60                  


Met Val Thr Ile Ile Leu Leu Leu Ser Cys Asp Phe Trp Ala Val Lys 
65                  70                  75                  80  


Asn Val Thr Gly Arg Leu Met Val Gly Leu Arg Trp Trp Asn His Ile 
                85                  90                  95      


Asp Glu Asp Gly Lys Ser His Trp Val Phe Glu Ser Arg Lys Glu Ser 
            100                 105                 110         


Ser Gln Glu Asn Lys Thr Val Ser Glu Ala Glu Ser Arg Ile Phe Trp 
        115                 120                 125             


Leu Gly Leu Ile Ala Cys Pro Val Leu Trp Val Ile Phe Ala Phe Ser 
    130                 135                 140                 


Ala Leu Phe Ser Phe Arg Val Lys Trp Leu Ala Val Val Ile Met Gly 
145                 150                 155                 160 


Val Val Leu Gln Gly Ala Asn Leu Tyr Gly Tyr Ile Arg Cys Lys Val 
                165                 170                 175     


Arg Ser Arg Lys His Leu Thr Ser Met Ala Thr Ser Tyr Phe Gly Lys 
            180                 185                 190         


Gln Phe Leu Arg Gln Asn Thr Gly Asp Asp Gln Thr Ser 
        195                 200                 205 


<210>  4164
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  4164

Met Gly Leu Phe Gly Lys Thr Gln Glu Lys Pro Pro Lys Glu Leu Val 
1               5                   10                  15      


Asn Glu Trp Ser Leu Lys Ile Arg Lys Glu Met Arg Val Val Asp Arg 
            20                  25                  30          


Gln Ile Arg Asp Ile Gln Arg Glu Glu Glu Lys Val Lys Arg Ser Val 
        35                  40                  45              


Lys Asp Ala Ala Lys Lys Gly Gln Lys Asp Val Cys Ile Val Leu Ala 
    50                  55                  60                  


Lys Glu Met Ile Arg Ser Arg Lys Ala Val Ser Lys Leu Tyr Ala Ser 
65                  70                  75                  80  


Lys Ala His Met Asn Ser Val Leu Met Gly Met Lys Asn Gln Leu Ala 
                85                  90                  95      


Val Leu Arg Val Ala Gly Ser Leu Gln Lys Ser Thr Glu Val Met Lys 
            100                 105                 110         


Ala Met Gln Ser Leu Val Lys Ile Pro Glu Ile Gln Ala Thr Met Arg 
        115                 120                 125             


Glu Leu Ser Lys Glu Met Met Lys Ala Gly Ile Ile Glu Glu Met Leu 
    130                 135                 140                 


Glu Asp Thr Phe Glu Ser Met Asp Asp Gln Glu Glu Met Glu Glu Glu 
145                 150                 155                 160 


Ala Glu Met Glu Ile Asp Arg Ile Leu Phe Glu Ile Thr Ala Gly Ala 
                165                 170                 175     


Leu Gly Lys Ala Pro Ser Lys Val Thr Asp Ala Leu Pro Glu Pro Glu 
            180                 185                 190         


Pro Pro Gly Ala Met Ala Ala Ser Glu Asp Glu Glu Glu Glu Glu Glu 
        195                 200                 205             


Ala Leu Glu Ala Met Gln Ser Arg Leu Ala Thr Leu Arg Ser 
    210                 215                 220         


<210>  4165
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  4165

Met Lys Ser Ile Leu Asp Gly Leu Ala Asp Thr Thr Phe Arg Thr Ile 
1               5                   10                  15      


Thr Thr Asp Leu Leu Tyr Val Gly Ser Asn Asp Ile Gln Tyr Glu Asp 
            20                  25                  30          


Ile Lys Gly Asp Met Ala Ser Lys Leu Gly Tyr Phe Pro Gln Lys Phe 
        35                  40                  45              


Pro Leu Thr Ser Phe Arg Gly Ser Pro Phe Gln Glu Lys Met Thr Ala 
    50                  55                  60                  


Gly Asp Asn Pro Gln Leu Val Pro Ala Asp Gln Val Asn Ile Thr Glu 
65                  70                  75                  80  


Phe Tyr Asn Lys Ser Leu Ser Ser Phe Lys Glu Asn Glu Glu Asn Ile 
                85                  90                  95      


Gln Cys Gly Glu Asn Phe Met Asp Ile Glu Cys Phe Met Val Leu Asn 
            100                 105                 110         


Pro Ser Gln Gln Leu Ala Ile Ala Val Leu Ser Leu Thr Leu Gly Thr 
        115                 120                 125             


Phe Thr Val Leu Glu Asn Leu Leu Val Leu Cys Val Ile Leu His Ser 
    130                 135                 140                 


Arg Ser Leu Arg Cys Arg Pro Ser Tyr His Phe Ile Gly Ser Leu Ala 
145                 150                 155                 160 


Val Ala Asp Leu Leu Gly Ser Val Ile Phe Val Tyr Ser Phe Ile Asp 
                165                 170                 175     


Phe His Val Phe His Arg Lys Asp Ser Arg Asn Val Phe Leu Phe Lys 
            180                 185                 190         


Leu Gly Gly Val Thr Ala Ser Phe Thr Ala Ser Val Gly Ser Leu Phe 
        195                 200                 205             


Leu Thr Ala Ile Asp Arg Tyr Ile Ser Ile His Arg Pro Leu Ala Tyr 
    210                 215                 220                 


Lys Arg Ile Val Thr Arg Pro Lys Ala Val Val Ala Phe Cys Leu Met 
225                 230                 235                 240 


Trp Thr Ile Ala Ile Val Ile Ala Val Leu Pro Leu Leu Gly Trp Asn 
                245                 250                 255     


Cys Glu Lys Leu Gln Ser Val Cys Ser Asp Ile Phe Pro His Ile Asp 
            260                 265                 270         


Glu Thr Tyr Leu Met Phe Trp Ile Gly Val Thr Ser Val Leu Leu Leu 
        275                 280                 285             


Phe Ile Val Tyr Ala Tyr Met Tyr Ile Leu Trp Lys Ala His Ser His 
    290                 295                 300                 


Ala Val Arg Met Ile Gln Arg Gly Thr Gln Lys Ser Ile Ile Ile His 
305                 310                 315                 320 


Thr Ser Glu Asp Gly Lys Val Gln Val Thr Arg Pro Asp Gln Ala Arg 
                325                 330                 335     


Met Asp Ile Arg Leu Ala Lys Thr Leu Val Leu Ile Leu Val Val Leu 
            340                 345                 350         


Ile Ile Cys Trp Gly Pro Leu Leu Ala Ile Met Val Tyr Asp Val Phe 
        355                 360                 365             


Gly Lys Met Asn Lys Leu Ile Lys Thr Val Phe Ala Phe Cys Ser Met 
    370                 375                 380                 


Leu Cys Leu Leu Asn Ser Thr Val Asn Pro Ile Ile Tyr Ala Leu Arg 
385                 390                 395                 400 


Ser Lys Asp Leu Arg His Ala Phe Arg Ser Met Phe Pro Ser Cys Glu 
                405                 410                 415     


Gly Thr Ala Gln Pro Leu Asp Asn Ser Met Gly Asp Ser Asp Cys Leu 
            420                 425                 430         


His Lys His Ala Asn Asn Ala Ala Ser Val His Arg Ala Ala Glu Ser 
        435                 440                 445             


Cys Ile Lys Ser Thr Val Lys Ile Ala Lys Val Thr Met Ser Val Ser 
    450                 455                 460                 


Thr Asp Thr Ser Ala Glu Ala Leu 
465                 470         


<210>  4166
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  4166

Met Leu His Ala Arg Cys Cys Leu Asn Gln Lys Gly Thr Ile Leu Gly 
1               5                   10                  15      


Leu Asp Leu Gln Asn Cys Ser Leu Glu Asp Pro Gly Pro Asn Phe His 
            20                  25                  30          


Gln Ala His Thr Thr Val Ile Ile Asp Leu Gln Ala Asn Pro Leu Lys 
        35                  40                  45              


Gly Asp Leu Ala Asn Thr Phe Arg Gly Phe Thr Gln Leu Gln Thr Leu 
    50                  55                  60                  


Ile Leu Pro Gln His Val Asn Cys Pro Gly Gly Ile Asn Ala Trp Asn 
65                  70                  75                  80  


Thr Ile Thr Ser Tyr Ile Asp Asn Gln Ile Cys Gln Gly Gln Lys Asn 
                85                  90                  95      


Leu Cys Asn Asn Thr Gly Asp Pro Glu Met Cys Pro Glu Asn Gly Ser 
            100                 105                 110         


Cys Val Pro Asp Gly Pro Gly Leu Leu Gln Cys Val Cys Ala Asp Gly 
        115                 120                 125             


Phe His Gly Tyr Lys Cys Met Arg Gln Gly Ser Phe Ser Leu Leu Met 
    130                 135                 140                 


Phe Phe Gly Ile Leu Gly Ala Thr Thr Leu Ser Val Ser Ile Leu Leu 
145                 150                 155                 160 


Trp Ala Thr Gln Arg Arg Lys Ala Lys Thr Ser 
                165                 170     


<210>  4167
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  4167

Met Gln Leu Thr Thr Cys Leu Arg Glu Thr Leu Phe Thr Gly Ala Ser 
1               5                   10                  15      


Gln Lys Thr Ser Leu Trp Trp Leu Gly Ile Ala Ser Phe Gly Val Pro 
            20                  25                  30          


Glu Lys Leu Gly Cys Ala Asn Leu Pro Leu Asn Ser Arg Gln Lys Glu 
        35                  40                  45              


Leu Cys Lys Arg Lys Pro Tyr Leu Leu Pro Ser Ile Arg Glu Gly Ala 
    50                  55                  60                  


Arg Leu Gly Ile Gln Glu Cys Gly Ser Gln Phe Arg His Glu Arg Trp 
65                  70                  75                  80  


Asn Cys Met Ile Thr Ala Ala Ala Thr Thr Ala Pro Met Gly Ala Ser 
                85                  90                  95      


Pro Leu Phe Gly Tyr Glu Leu Ser Ser Gly Thr Lys Glu Thr Ala Phe 
            100                 105                 110         


Ile Tyr Ala Val Met Ala Ala Gly Leu Val His Ser Val Thr Arg Ser 
        115                 120                 125             


Cys Ser Ala Gly Asn Met Thr Glu Cys Ser Cys Asp Thr Thr Leu Gln 
    130                 135                 140                 


Asn Gly Gly Ser Ala Ser Glu Gly Trp His Trp Gly Gly Cys Ser Asp 
145                 150                 155                 160 


Asp Val Gln Tyr Gly Met Trp Phe Ser Arg Lys Phe Leu Asp Phe Pro 
                165                 170                 175     


Ile Gly Asn Thr Thr Gly Lys Glu Asn Lys Val Leu Leu Ala Met Asn 
            180                 185                 190         


Leu His Asn Asn Glu Ala Gly Arg Gln Ala Val Ala Lys Leu Met Ser 
        195                 200                 205             


Val Asp Cys Arg Cys His Gly Val Ser Gly Ser Cys Ala Val Lys Thr 
    210                 215                 220                 


Cys Trp Lys Thr Met Ser Ser Phe Glu Lys Ile Gly His Leu Leu Lys 
225                 230                 235                 240 


Asp Lys Tyr Glu Asn Ser Ile Gln Ile Ser Asp Lys Thr Lys Arg Lys 
                245                 250                 255     


Met Arg Arg Arg Glu Lys Asp Gln Arg Lys Ile Pro Ile His Lys Asp 
            260                 265                 270         


Asp Leu Leu Tyr Val Asn Lys Ser Pro Asn Tyr Cys Val Glu Asp Lys 
        275                 280                 285             


Lys Leu Gly Ile Pro Gly Thr Gln Gly Arg Glu Cys Asn Arg Thr Ser 
    290                 295                 300                 


Glu Gly Ala Asp Gly Cys Asn Leu Leu Cys Cys Gly Arg Gly Tyr Asn 
305                 310                 315                 320 


Thr His Val Val Arg His Val Glu Arg Cys Glu Cys Lys Phe Ile Trp 
                325                 330                 335     


Cys Cys Tyr Val Arg Cys Arg Arg Cys Glu Ser Met Thr Asp Val His 
            340                 345                 350         


Thr Cys Lys 
        355 


<210>  4168
<211>  82
<212>  PRT
<213>  Homo sapiens

<400>  4168

Met Ala Phe Thr Leu Tyr Ser Leu Leu Gln Ala Ala Leu Leu Cys Val 
1               5                   10                  15      


Asn Ala Ile Ala Val Leu His Glu Glu Arg Phe Leu Lys Asn Ile Gly 
            20                  25                  30          


Trp Gly Thr Asp Gln Gly Ile Gly Gly Phe Gly Glu Glu Pro Gly Ile 
        35                  40                  45              


Lys Ser Gln Leu Met Asn Leu Ile Arg Ser Val Arg Thr Val Met Arg 
    50                  55                  60                  


Val Pro Leu Ile Ile Val Asn Ser Ile Ala Ile Val Leu Leu Leu Leu 
65                  70                  75                  80  


Phe Gly 
        


<210>  4169
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  4169

Met Ala Gly Ala Leu Val Arg Lys Ala Ala Asp Tyr Val Arg Ser Lys 
1               5                   10                  15      


Asp Phe Arg Asp Tyr Leu Met Ser Thr His Phe Trp Gly Pro Val Ala 
            20                  25                  30          


Asn Trp Gly Leu Pro Ile Ala Ala Ile Asn Asp Met Lys Lys Ser Pro 
        35                  40                  45              


Glu Ile Ile Ser Gly Arg Met Thr Phe Ala Leu Cys Cys Tyr Ser Leu 
    50                  55                  60                  


Thr Phe Met Arg Phe Ala Tyr Lys Val Gln Pro Arg Asn Trp Leu Leu 
65                  70                  75                  80  


Phe Ala Cys His Ala Thr Asn Glu Val Ala Gln Leu Ile Gln Gly Gly 
                85                  90                  95      


Arg Leu Ile Lys His Glu Met Thr Lys Thr Ala Ser Ala 
            100                 105                 


<210>  4170
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  4170

Met Ala Leu Val Pro Cys Gln Val Leu Arg Met Ala Ile Leu Leu Ser 
1               5                   10                  15      


Tyr Cys Ser Ile Leu Cys Asn Tyr Lys Ala Ile Glu Met Pro Ser His 
            20                  25                  30          


Gln Thr Tyr Gly Gly Ser Trp Lys Phe Leu Thr Phe Ile Asp Leu Val 
        35                  40                  45              


Ile Gln Ala Val Phe Phe Gly Ile Cys Val Leu Thr Asp Leu Ser Ser 
    50                  55                  60                  


Leu Leu Thr Arg Gly Ser Gly Asn Gln Glu Gln Glu Arg Gln Leu Lys 
65                  70                  75                  80  


Lys Leu Ile Ser Leu Arg Asp Trp Met Leu Ala Val Leu Ala Phe Pro 
                85                  90                  95      


Val Gly Val Phe Val Val Ala Val Phe Trp Ile Ile Tyr Ala Tyr Asp 
            100                 105                 110         


Arg Glu Met Ile Tyr Pro Lys Leu Leu Asp Asn Phe Ile Pro Gly Trp 
        115                 120                 125             


Leu Asn His Gly Met His Thr Thr Val Leu Pro Phe Ile Leu Ile Glu 
    130                 135                 140                 


Met Arg Thr Ser His His Gln Tyr Pro Ser Arg Ser Ser Gly Leu Thr 
145                 150                 155                 160 


Ala Ile Cys Thr Phe Ser Val Gly Tyr Ile Leu Trp Val Cys Trp Val 
                165                 170                 175     


His His Val Thr Gly Met Trp Val Tyr Pro Phe Leu Glu His Ile Gly 
            180                 185                 190         


Pro Gly Ala Arg Ile Ile Phe Phe Gly Ser Thr Thr Ile Leu Met Asn 
        195                 200                 205             


Phe Leu Tyr Leu Leu Gly Glu Val Leu Asn Asn Tyr Ile Trp Asp Thr 
    210                 215                 220                 


Gln Lys Ser Met Glu Glu Glu Lys Glu Lys Pro Lys Leu Glu 
225                 230                 235             


<210>  4171
<211>  805
<212>  PRT
<213>  Homo sapiens

<400>  4171

Met Asn Ala Val Gly Ser Pro Glu Gly Gln Glu Leu Gln Lys Leu Gly 
1               5                   10                  15      


Ser Gly Ala Trp Asp Asn Pro Ala Tyr Ser Gly Pro Pro Ser Pro His 
            20                  25                  30          


Gly Thr Leu Arg Val Cys Thr Ile Ser Ser Thr Gly Pro Leu Gln Pro 
        35                  40                  45              


Gln Pro Lys Lys Pro Glu Asp Glu Pro Gln Glu Thr Ala Tyr Arg Thr 
    50                  55                  60                  


Gln Val Ser Ser Cys Cys Leu His Ile Cys Gln Gly Ile Arg Gly Leu 
65                  70                  75                  80  


Trp Gly Thr Thr Leu Thr Glu Asn Thr Ala Glu Asn Arg Glu Leu Tyr 
                85                  90                  95      


Ile Lys Thr Thr Leu Arg Glu Leu Leu Val Tyr Ile Val Phe Leu Val 
            100                 105                 110         


Asp Ile Cys Leu Leu Thr Tyr Gly Met Thr Ser Ser Ser Ala Tyr Tyr 
        115                 120                 125             


Tyr Thr Lys Val Met Ser Glu Leu Phe Leu His Thr Pro Ser Asp Thr 
    130                 135                 140                 


Gly Val Ser Phe Gln Ala Ile Ser Ser Met Ala Asp Phe Trp Asp Phe 
145                 150                 155                 160 


Ala Gln Gly Pro Leu Leu Asp Ser Leu Tyr Trp Thr Lys Trp Tyr Asn 
                165                 170                 175     


Asn Gln Ser Leu Gly His Gly Ser His Ser Phe Ile Tyr Tyr Glu Asn 
            180                 185                 190         


Met Leu Leu Gly Val Pro Arg Leu Arg Gln Leu Lys Val Arg Asn Asp 
        195                 200                 205             


Ser Cys Val Val His Glu Asp Phe Arg Glu Asp Ile Leu Ser Cys Tyr 
    210                 215                 220                 


Asp Val Tyr Ser Pro Asp Lys Glu Glu Gln Leu Pro Phe Gly Pro Phe 
225                 230                 235                 240 


Asn Gly Thr Ala Trp Thr Tyr His Ser Gln Asp Glu Leu Gly Gly Phe 
                245                 250                 255     


Ser His Trp Gly Arg Leu Thr Ser Tyr Ser Gly Gly Gly Tyr Tyr Leu 
            260                 265                 270         


Asp Leu Pro Gly Ser Arg Gln Gly Ser Ala Glu Ala Leu Arg Ala Leu 
        275                 280                 285             


Gln Glu Gly Leu Trp Leu Asp Arg Gly Thr Arg Val Val Phe Ile Asp 
    290                 295                 300                 


Phe Ser Val Tyr Asn Ala Asn Ile Asn Leu Phe Cys Val Leu Arg Leu 
305                 310                 315                 320 


Val Val Glu Phe Pro Ala Thr Gly Gly Ala Ile Pro Ser Trp Gln Ile 
                325                 330                 335     


Arg Thr Val Lys Leu Ile Arg Tyr Val Ser Asn Trp Asp Phe Phe Ile 
            340                 345                 350         


Val Gly Cys Glu Val Ile Phe Cys Val Phe Ile Phe Tyr Tyr Val Val 
        355                 360                 365             


Glu Glu Ile Leu Glu Leu His Ile His Arg Leu Arg Tyr Leu Ser Ser 
    370                 375                 380                 


Ile Trp Asn Ile Leu Asp Leu Val Val Ile Leu Leu Ser Ile Val Ala 
385                 390                 395                 400 


Val Gly Phe His Ile Phe Arg Thr Leu Glu Val Asn Arg Leu Met Gly 
                405                 410                 415     


Lys Leu Leu Gln Gln Pro Asn Thr Tyr Ala Asp Phe Glu Phe Leu Ala 
            420                 425                 430         


Phe Trp Gln Thr Gln Tyr Asn Asn Met Asn Ala Val Asn Leu Phe Phe 
        435                 440                 445             


Ala Trp Ile Lys Ile Phe Lys Tyr Ile Ser Phe Asn Lys Thr Met Thr 
    450                 455                 460                 


Gln Leu Ser Ser Thr Leu Ala Arg Cys Ala Lys Asp Ile Leu Gly Phe 
465                 470                 475                 480 


Ala Val Met Phe Phe Ile Val Phe Phe Ala Tyr Ala Gln Leu Gly Tyr 
                485                 490                 495     


Leu Leu Phe Gly Thr Gln Val Glu Asn Phe Ser Thr Phe Ile Lys Cys 
            500                 505                 510         


Ile Phe Thr Gln Phe Arg Ile Ile Leu Gly Asp Phe Asp Tyr Asn Ala 
        515                 520                 525             


Ile Asp Asn Ala Asn Arg Ile Leu Gly Pro Ala Tyr Phe Val Thr Tyr 
    530                 535                 540                 


Val Phe Phe Val Phe Phe Val Leu Leu Asn Met Phe Leu Ala Ile Ile 
545                 550                 555                 560 


Asn Asp Thr Tyr Ser Glu Val Lys Glu Glu Leu Ala Gly Gln Lys Asp 
                565                 570                 575     


Glu Leu Gln Leu Ser Asp Leu Leu Lys Gln Gly Tyr Asn Lys Thr Leu 
            580                 585                 590         


Leu Arg Leu Arg Leu Arg Lys Glu Arg Val Ser Asp Val Gln Lys Val 
        595                 600                 605             


Leu Gln Gly Gly Glu Gln Glu Ile Gln Phe Glu Asp Phe Thr Asn Thr 
    610                 615                 620                 


Leu Arg Glu Leu Gly His Ala Glu His Glu Ile Thr Glu Leu Thr Ala 
625                 630                 635                 640 


Thr Phe Thr Lys Phe Asp Arg Asp Gly Asn Arg Ile Leu Asp Glu Lys 
                645                 650                 655     


Glu Gln Glu Lys Met Arg Gln Asp Leu Glu Glu Glu Arg Val Ala Leu 
            660                 665                 670         


Asn Thr Glu Ile Glu Lys Leu Gly Arg Ser Ile Val Ser Ser Pro Gln 
        675                 680                 685             


Gly Lys Ser Gly Pro Glu Ala Ala Arg Ala Gly Gly Trp Val Ser Gly 
    690                 695                 700                 


Glu Glu Phe Tyr Met Leu Thr Arg Arg Val Leu Gln Leu Glu Thr Val 
705                 710                 715                 720 


Leu Glu Gly Val Val Ser Gln Ile Asp Ala Val Gly Ser Lys Leu Lys 
                725                 730                 735     


Met Leu Glu Arg Lys Gly Trp Leu Ala Pro Ser Pro Gly Val Lys Glu 
            740                 745                 750         


Gln Ala Ile Trp Lys His Pro Gln Pro Ala Pro Ala Val Thr Pro Asp 
        755                 760                 765             


Pro Trp Gly Val Gln Gly Gly Gln Glu Ser Glu Val Pro Tyr Lys Arg 
    770                 775                 780                 


Glu Glu Glu Ala Leu Glu Glu Arg Arg Leu Ser Arg Gly Glu Ile Pro 
785                 790                 795                 800 


Thr Leu Gln Arg Ser 
                805 


<210>  4172
<211>  764
<212>  PRT
<213>  Homo sapiens

<400>  4172

Met Thr Ser Pro Ser Ser Ser Pro Val Phe Arg Leu Glu Thr Leu Asp 
1               5                   10                  15      


Gly Gly Gln Glu Asp Gly Ser Glu Ala Asp Arg Gly Lys Leu Asp Phe 
            20                  25                  30          


Gly Ser Gly Leu Pro Pro Met Glu Ser Gln Phe Gln Gly Glu Asp Arg 
        35                  40                  45              


Lys Phe Ala Pro Gln Ile Arg Val Asn Leu Asn Tyr Arg Lys Gly Thr 
    50                  55                  60                  


Gly Ala Ser Gln Pro Asp Pro Asn Arg Phe Asp Arg Asp Arg Leu Phe 
65                  70                  75                  80  


Asn Ala Val Ser Arg Gly Val Pro Glu Asp Leu Ala Gly Leu Pro Glu 
                85                  90                  95      


Tyr Leu Ser Lys Thr Ser Lys Tyr Leu Thr Asp Ser Glu Tyr Thr Glu 
            100                 105                 110         


Gly Ser Thr Gly Lys Thr Cys Leu Met Lys Ala Val Leu Asn Leu Lys 
        115                 120                 125             


Asp Gly Val Asn Ala Cys Ile Leu Pro Leu Leu Gln Ile Asp Arg Asp 
    130                 135                 140                 


Ser Gly Asn Pro Gln Pro Leu Val Asn Ala Gln Cys Thr Asp Asp Tyr 
145                 150                 155                 160 


Tyr Arg Gly His Ser Ala Leu His Ile Ala Ile Glu Lys Arg Ser Leu 
                165                 170                 175     


Gln Cys Val Lys Leu Leu Val Glu Asn Gly Ala Asn Val His Ala Arg 
            180                 185                 190         


Ala Cys Gly Arg Phe Phe Gln Lys Gly Gln Gly Thr Cys Phe Tyr Phe 
        195                 200                 205             


Gly Glu Leu Pro Leu Ser Leu Ala Ala Cys Thr Lys Gln Trp Asp Val 
    210                 215                 220                 


Val Ser Tyr Leu Leu Glu Asn Pro His Gln Pro Ala Ser Leu Gln Ala 
225                 230                 235                 240 


Thr Asp Ser Gln Gly Asn Thr Val Leu His Ala Leu Val Met Ile Ser 
                245                 250                 255     


Asp Asn Ser Ala Glu Asn Ile Ala Leu Val Thr Ser Met Tyr Asp Gly 
            260                 265                 270         


Leu Leu Gln Ala Gly Ala Arg Leu Cys Pro Thr Val Gln Leu Glu Asp 
        275                 280                 285             


Ile Arg Asn Leu Gln Asp Leu Thr Pro Leu Lys Leu Ala Ala Lys Glu 
    290                 295                 300                 


Gly Lys Ile Glu Ile Phe Arg His Ile Leu Gln Arg Glu Phe Ser Gly 
305                 310                 315                 320 


Leu Ser His Leu Ser Arg Lys Phe Thr Glu Trp Cys Tyr Gly Pro Val 
                325                 330                 335     


Arg Val Ser Leu Tyr Asp Leu Ala Ser Val Asp Ser Cys Glu Glu Asn 
            340                 345                 350         


Ser Val Leu Glu Ile Ile Ala Phe His Cys Lys Ser Pro His Arg His 
        355                 360                 365             


Arg Met Val Val Leu Glu Pro Leu Asn Lys Leu Leu Gln Ala Lys Trp 
    370                 375                 380                 


Asp Leu Leu Ile Pro Lys Phe Phe Leu Asn Phe Leu Cys Asn Leu Ile 
385                 390                 395                 400 


Tyr Met Phe Ile Phe Thr Ala Val Ala Tyr His Gln Pro Thr Leu Lys 
                405                 410                 415     


Lys Gln Ala Ala Pro His Leu Lys Ala Glu Val Gly Asn Ser Met Leu 
            420                 425                 430         


Leu Thr Gly His Ile Leu Ile Leu Leu Gly Gly Ile Tyr Leu Leu Val 
        435                 440                 445             


Gly Gln Leu Trp Tyr Phe Trp Arg Arg His Val Phe Ile Trp Ile Ser 
    450                 455                 460                 


Phe Ile Asp Ser Tyr Phe Glu Ile Leu Phe Leu Phe Gln Ala Leu Leu 
465                 470                 475                 480 


Thr Val Val Ser Gln Val Leu Cys Phe Leu Ala Ile Glu Trp Tyr Leu 
                485                 490                 495     


Pro Leu Leu Val Ser Ala Leu Val Leu Gly Trp Leu Asn Leu Leu Tyr 
            500                 505                 510         


Tyr Thr Arg Gly Phe Gln His Thr Gly Ile Tyr Ser Val Met Ile Gln 
        515                 520                 525             


Lys Val Ile Leu Arg Asp Leu Leu Arg Phe Leu Leu Ile Tyr Leu Val 
    530                 535                 540                 


Phe Leu Phe Gly Phe Ala Val Ala Leu Val Ser Leu Ser Gln Glu Ala 
545                 550                 555                 560 


Trp Arg Pro Glu Ala Pro Thr Gly Pro Asn Ala Thr Glu Ser Val Gln 
                565                 570                 575     


Pro Met Glu Gly Gln Glu Asp Glu Gly Asn Gly Ala Gln Tyr Arg Gly 
            580                 585                 590         


Ile Leu Glu Ala Ser Leu Glu Leu Phe Lys Phe Thr Ile Gly Met Gly 
        595                 600                 605             


Glu Leu Ala Phe Gln Glu Gln Leu His Phe Arg Gly Met Val Leu Leu 
    610                 615                 620                 


Leu Leu Leu Ala Tyr Val Leu Leu Thr Tyr Ile Leu Leu Leu Asn Met 
625                 630                 635                 640 


Leu Ile Ala Leu Met Ser Glu Thr Val Asn Ser Val Ala Thr Asp Ser 
                645                 650                 655     


Trp Ser Ile Trp Lys Leu Gln Lys Ala Ile Ser Val Leu Glu Met Glu 
            660                 665                 670         


Asn Gly Tyr Trp Trp Cys Arg Lys Lys Gln Arg Ala Gly Val Met Leu 
        675                 680                 685             


Thr Val Gly Thr Lys Pro Asp Gly Ser Pro Asp Glu Arg Trp Cys Phe 
    690                 695                 700                 


Arg Val Glu Glu Val Asn Trp Ala Ser Trp Glu Gln Thr Leu Pro Thr 
705                 710                 715                 720 


Leu Cys Glu Asp Pro Ser Gly Ala Gly Val Pro Arg Thr Leu Glu Asn 
                725                 730                 735     


Pro Val Leu Ala Ser Pro Pro Lys Glu Asp Glu Asp Gly Ala Ser Glu 
            740                 745                 750         


Glu Asn Tyr Val Pro Val Gln Leu Leu Gln Ser Asn 
        755                 760                 


<210>  4173
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  4173

Met Ser Ser Lys Tyr Pro Arg Ser Val Arg Arg Cys Leu Pro Leu Trp 
1               5                   10                  15      


Ala Leu Thr Leu Glu Ala Ala Leu Ile Leu Leu Phe Tyr Phe Phe Thr 
            20                  25                  30          


His Tyr Asp Ala Ser Leu Glu Asp Gln Lys Gly Leu Val Ala Ser Tyr 
        35                  40                  45              


Gln Val Gly Gln Asp Leu Thr Val Met Ala Ala Ile Gly Leu Gly Phe 
    50                  55                  60                  


Leu Thr Ser Ser Phe Arg Arg His Ser Trp Ser Ser Val Ala Phe Asn 
65                  70                  75                  80  


Leu Phe Met Leu Ala Leu Gly Val Gln Trp Ala Ile Leu Leu Asp Gly 
                85                  90                  95      


Phe Leu Ser Gln Phe Pro Ser Gly Lys Val Val Ile Thr Leu Phe Ser 
            100                 105                 110         


Ile Arg Leu Ala Thr Met Ser Ala Leu Ser Val Leu Ile Ser Val Asp 
        115                 120                 125             


Ala Val Leu Gly Lys Val Asn Leu Ala Gln Leu Val Val Met Val Leu 
    130                 135                 140                 


Val Glu Val Thr Ala Leu Gly Asn Leu Arg Met Val Ile Ser Asn Ile 
145                 150                 155                 160 


Phe Asn Thr Asp Tyr His Met Asn Met Met His Ile Tyr Val Phe Ala 
                165                 170                 175     


Ala Tyr Phe Gly Leu Ser Val Ala Trp Cys Leu Pro Lys Pro Leu Pro 
            180                 185                 190         


Glu Gly Thr Glu Asp Lys Asp Gln Thr Ala Thr Ile Pro Ser Leu Ser 
        195                 200                 205             


Ala Met Leu Gly Ala Leu Phe Leu Trp Met Phe Trp Pro Ser Phe Asn 
    210                 215                 220                 


Ser Ala Leu Leu Arg Ser Pro Ile Glu Arg Lys Asn Ala Val Phe Asn 
225                 230                 235                 240 


Thr Tyr Tyr Ala Val Ala Val Ser Val Val Thr Ala Ile Ser Gly Ser 
                245                 250                 255     


Ser Leu Ala His Pro Gln Gly Lys Ile Ser Lys Thr Tyr Val His Ser 
            260                 265                 270         


Ala Val Leu Ala Gly Gly Val Ala Val Gly Thr Ser Cys His Leu Ile 
        275                 280                 285             


Pro Ser Pro Trp Leu Ala Met Val Leu Gly Leu Val Ala Gly Leu Ile 
    290                 295                 300                 


Ser Val Gly Gly Ala Lys Tyr Leu Pro Gly Cys Cys Asn Arg Val Leu 
305                 310                 315                 320 


Gly Ile Pro His Ser Ser Ile Met Gly Tyr Asn Phe Ser Leu Leu Gly 
                325                 330                 335     


Leu Leu Gly Glu Ile Ile Tyr Ile Val Leu Leu Val Leu Asp Thr Val 
            340                 345                 350         


Gly Ala Gly Asn Gly Met Ile Gly Phe Gln Val Leu Leu Ser Ile Gly 
        355                 360                 365             


Glu Leu Ser Leu Ala Ile Val Ile Ala Leu Thr Ser Gly Leu Leu Thr 
    370                 375                 380                 


Gly Leu Leu Leu Asn Leu Lys Ile Trp Lys Ala Pro His Glu Ala Lys 
385                 390                 395                 400 


Tyr Phe Asp Asp Gln Val Phe Trp Lys Phe Pro His Leu Ala Val Gly 
                405                 410                 415     


Phe 
    


<210>  4174
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  4174

Met Ala Glu Gly Glu Thr Glu Ser Pro Gly Pro Lys Lys Cys Gly Pro 
1               5                   10                  15      


Tyr Ile Ser Ser Val Thr Ser Gln Ser Val Asn Leu Met Ile Arg Gly 
            20                  25                  30          


Val Val Leu Phe Phe Ile Gly Val Phe Leu Ala Leu Val Leu Asn Leu 
        35                  40                  45              


Leu Gln Ile Gln Arg Asn Val Thr Leu Phe Pro Pro Asp Val Ile Ala 
    50                  55                  60                  


Ser Ile Phe Ser Ser Ala Trp Trp Val Pro Pro Cys Cys Gly Thr Ala 
65                  70                  75                  80  


Ser Ala Val Ile Gly Leu Leu Tyr Pro Cys Ile Asp Arg His Leu Gly 
                85                  90                  95      


Glu Pro His Lys Phe Lys Arg Glu Trp Ser Ser Val Met Arg Cys Val 
            100                 105                 110         


Ala Val Phe Val Gly Ile Asn His Ala Ser Ala Lys Val Asp Phe Asp 
        115                 120                 125             


Asn Asn Ile Gln Leu Ser Leu Thr Leu Ala Ala Leu Ser Ile Gly Leu 
    130                 135                 140                 


Trp Trp Thr Phe Asp Arg Ser Arg Ser Gly Phe Gly Leu Gly Val Gly 
145                 150                 155                 160 


Ile Ala Phe Leu Ala Thr Val Val Thr Gln Leu Leu Val Tyr Asn Gly 
                165                 170                 175     


Val Tyr Gln Tyr Thr Ser Pro Asp Phe Leu Tyr Val Arg Ser Trp Leu 
            180                 185                 190         


Pro Cys Ile Phe Phe Ala Gly Gly Ile Thr Met Gly Asn Ile Gly Arg 
        195                 200                 205             


Gln Leu Ala Met Tyr Glu Cys Lys Val Ile Ala Glu Lys Ser His Gln 
    210                 215                 220                 


Glu 
225 


<210>  4175
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  4175

Met Ser Cys Ala Gly Ala Ala Ala Ala Pro Arg Leu Trp Arg Leu Arg 
1               5                   10                  15      


Pro Gly Ala Arg Arg Ser Leu Ser Ala Tyr Gly Arg Arg Thr Ser Val 
            20                  25                  30          


Arg Phe Arg Ser Ser Gly Met Thr Leu Asp Asn Ile Ser Arg Ala Ala 
        35                  40                  45              


Val Asp Arg Ile Ile Arg Val Asp His Ala Gly Glu Tyr Gly Ala Asn 
    50                  55                  60                  


Arg Ile Tyr Ala Gly Gln Met Ala Val Leu Gly Arg Thr Ser Val Gly 
65                  70                  75                  80  


Pro Val Ile Gln Lys Met Trp Asp Gln Glu Lys Asp His Leu Lys Lys 
                85                  90                  95      


Phe Asn Glu Leu Met Val Thr Phe Arg Val Arg Pro Thr Val Leu Met 
            100                 105                 110         


Pro Leu Trp Asn Val Leu Gly Phe Ala Leu Gly Ala Gly Thr Ala Leu 
        115                 120                 125             


Leu Gly Lys Glu Gly Ala Met Ala Cys Thr Val Ala Val Glu Glu Ser 
    130                 135                 140                 


Ile Ala His His Tyr Asn Asn Gln Ile Arg Thr Leu Met Glu Glu Asp 
145                 150                 155                 160 


Pro Glu Lys Tyr Glu Glu Leu Leu Gln Leu Ile Lys Lys Phe Arg Asp 
                165                 170                 175     


Glu Glu Leu Glu His His Asp Ile Gly Leu Asp His Asp Ala Glu Leu 
            180                 185                 190         


Ala Pro Ala Tyr Ala Val Leu Lys Ser Ile Ile Gln Ala Gly Cys Arg 
        195                 200                 205             


Val Ala Ile Tyr Leu Ser Glu Arg Leu 
    210                 215         


<210>  4176
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  4176

Met Glu Ser Ala Leu Pro Ala Ala Gly Phe Leu Tyr Trp Val Gly Ala 
1               5                   10                  15      


Gly Thr Val Ala Tyr Leu Ala Leu Arg Ile Ser Tyr Ser Leu Phe Thr 
            20                  25                  30          


Ala Leu Arg Val Trp Gly Val Gly Asn Glu Ala Gly Val Gly Pro Gly 
        35                  40                  45              


Leu Gly Glu Trp Ala Val Val Thr Gly Ser Thr Asp Gly Ile Gly Lys 
    50                  55                  60                  


Ser Tyr Ala Glu Glu Leu Ala Lys His Gly Met Lys Val Val Leu Ile 
65                  70                  75                  80  


Ser Arg Ser Lys Asp Lys Leu Asp Gln Val Ser Ser Glu Ile Lys Glu 
                85                  90                  95      


Lys Phe Lys Val Glu Thr Arg Thr Ile Ala Val Asp Phe Ala Ser Glu 
            100                 105                 110         


Asp Ile Tyr Asp Lys Ile Lys Thr Gly Leu Ala Gly Leu Glu Ile Gly 
        115                 120                 125             


Ile Leu Val Asn Asn Val Gly Met Ser Tyr Glu Tyr Pro Glu Tyr Phe 
    130                 135                 140                 


Leu Asp Val Pro Asp Leu Asp Asn Val Ile Lys Lys Met Ile Asn Ile 
145                 150                 155                 160 


Asn Ile Leu Ser Val Cys Lys Met Thr Gln Leu Val Leu Pro Gly Met 
                165                 170                 175     


Val Glu Arg Ser Lys Gly Ala Ile Leu Asn Ile Ser Ser Gly Ser Gly 
            180                 185                 190         


Met Leu Pro Val Pro Leu Leu Thr Ile Tyr Ser Ala Thr Lys Thr Phe 
        195                 200                 205             


Val Asp Phe Phe Ser Gln Cys Leu His Glu Glu Tyr Arg Ser Lys Gly 
    210                 215                 220                 


Val Phe Val Gln Ser Val Leu Pro Tyr Phe Val Ala Thr Lys Leu Ala 
225                 230                 235                 240 


Lys Ile Arg Lys Pro Thr Leu Asp Lys Pro Ser Pro Glu Thr Phe Val 
                245                 250                 255     


Lys Ser Ala Ile Lys Thr Val Gly Leu Gln Ser Arg Thr Asn Gly Tyr 
            260                 265                 270         


Leu Ile His Ala Leu Met Gly Ser Ile Ile Ser Asn Leu Pro Ser Trp 
        275                 280                 285             


Ile Tyr Leu Lys Ile Val Met Asn Met Asn Lys Ser Thr Arg Ala His 
    290                 295                 300                 


Tyr Leu Lys Lys Thr Lys Lys Asn 
305                 310         


<210>  4177
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  4177

Met Ser Thr Asn Asn Met Ser Asp Pro Arg Arg Pro Asn Lys Val Leu 
1               5                   10                  15      


Arg Tyr Lys Pro Pro Pro Ser Glu Cys Asn Pro Ala Leu Asp Asp Pro 
            20                  25                  30          


Thr Pro Asp Tyr Met Asn Leu Leu Gly Met Ile Phe Ser Met Cys Gly 
        35                  40                  45              


Leu Met Leu Lys Leu Lys Trp Cys Ala Trp Val Ala Val Tyr Cys Ser 
    50                  55                  60                  


Phe Ile Ser Phe Ala Asn Ser Arg Ser Ser Glu Asp Thr Lys Gln Met 
65                  70                  75                  80  


Met Ser Ser Phe Met Leu Ser Ile Ser Ala Val Val Met Ser Tyr Leu 
                85                  90                  95      


Gln Asn Pro Gln Pro Met Thr Pro Pro Trp 
            100                 105     


<210>  4178
<211>  1235
<212>  PRT
<213>  Homo sapiens

<400>  4178

Met Pro Ala Gly Gly Arg Ala Gly Ser Leu Lys Asp Pro Asp Val Ala 
1               5                   10                  15      


Glu Leu Phe Phe Lys Asp Asp Pro Glu Lys Leu Phe Ser Asp Leu Arg 
            20                  25                  30          


Glu Ile Gly His Gly Ser Phe Gly Ala Val Tyr Phe Ala Arg Asp Val 
        35                  40                  45              


Arg Asn Ser Glu Val Val Ala Ile Lys Lys Met Ser Tyr Ser Gly Lys 
    50                  55                  60                  


Gln Ser Asn Glu Lys Trp Gln Asp Ile Ile Lys Glu Val Arg Phe Leu 
65                  70                  75                  80  


Gln Lys Leu Arg His Pro Asn Thr Ile Gln Tyr Arg Gly Cys Tyr Leu 
                85                  90                  95      


Arg Glu His Thr Ala Trp Leu Val Met Glu Tyr Cys Leu Gly Ser Ala 
            100                 105                 110         


Ser Asp Leu Leu Glu Val His Lys Lys Pro Leu Gln Glu Val Glu Ile 
        115                 120                 125             


Ala Ala Val Thr His Gly Ala Leu Gln Gly Leu Ala Tyr Leu His Ser 
    130                 135                 140                 


His Asn Met Ile His Arg Asp Val Lys Ala Gly Asn Ile Leu Leu Ser 
145                 150                 155                 160 


Glu Pro Gly Leu Val Lys Leu Gly Asp Phe Gly Ser Ala Ser Ile Met 
                165                 170                 175     


Ala Pro Ala Asn Ser Phe Val Gly Thr Pro Tyr Trp Met Ala Pro Glu 
            180                 185                 190         


Val Ile Leu Ala Met Asp Glu Gly Gln Tyr Asp Gly Lys Val Asp Val 
        195                 200                 205             


Trp Ser Leu Gly Ile Thr Cys Ile Glu Leu Ala Glu Arg Lys Pro Pro 
    210                 215                 220                 


Leu Phe Asn Met Asn Ala Met Ser Ala Leu Tyr His Ile Ala Gln Asn 
225                 230                 235                 240 


Glu Ser Pro Val Leu Gln Ser Gly His Trp Ser Glu Tyr Phe Arg Asn 
                245                 250                 255     


Phe Val Asp Ser Cys Leu Gln Lys Ile Pro Gln Asp Arg Pro Thr Ser 
            260                 265                 270         


Glu Val Leu Leu Lys His Arg Phe Val Leu Arg Glu Arg Pro Pro Thr 
        275                 280                 285             


Val Ile Met Asp Leu Ile Gln Arg Thr Lys Asp Ala Val Arg Glu Leu 
    290                 295                 300                 


Asp Asn Leu Gln Tyr Arg Lys Met Lys Lys Ile Leu Phe Gln Glu Ala 
305                 310                 315                 320 


Pro Asn Gly Pro Gly Ala Glu Ala Pro Glu Glu Glu Glu Glu Ala Glu 
                325                 330                 335     


Pro Tyr Met His Arg Ala Gly Thr Leu Thr Ser Leu Glu Ser Ser His 
            340                 345                 350         


Ser Val Pro Ser Met Ser Ile Ser Ala Ser Ser Gln Ser Ser Ser Val 
        355                 360                 365             


Asn Ser Leu Ala Asp Ala Ser Asp Asn Glu Glu Glu Glu Glu Glu Glu 
    370                 375                 380                 


Glu Glu Glu Glu Glu Glu Glu Glu Gly Pro Glu Ala Arg Glu Met Ala 
385                 390                 395                 400 


Met Met Gln Glu Gly Glu His Thr Val Thr Ser His Ser Ser Ile Ile 
                405                 410                 415     


His Arg Leu Pro Gly Ser Asp Asn Leu Tyr Asp Asp Pro Tyr Gln Pro 
            420                 425                 430         


Glu Ile Thr Pro Ser Pro Leu Gln Pro Pro Ala Ala Pro Ala Pro Thr 
        435                 440                 445             


Ser Thr Thr Ser Ser Ala Arg Arg Arg Ala Tyr Cys Arg Asn Arg Asp 
    450                 455                 460                 


His Phe Ala Thr Ile Arg Thr Ala Ser Leu Val Ser Arg Gln Ile Gln 
465                 470                 475                 480 


Glu His Glu Gln Asp Ser Ala Leu Arg Glu Gln Leu Ser Gly Tyr Lys 
                485                 490                 495     


Arg Met Arg Arg Gln His Gln Lys Gln Leu Leu Ala Leu Glu Ser Arg 
            500                 505                 510         


Leu Arg Gly Glu Arg Glu Glu His Ser Ala Arg Leu Gln Arg Glu Leu 
        515                 520                 525             


Glu Ala Gln Arg Ala Gly Phe Gly Ala Glu Ala Glu Lys Leu Ala Arg 
    530                 535                 540                 


Arg His Gln Ala Ile Gly Glu Lys Glu Ala Arg Ala Ala Gln Ala Glu 
545                 550                 555                 560 


Glu Arg Lys Phe Gln Gln His Ile Leu Gly Gln Gln Lys Lys Glu Leu 
                565                 570                 575     


Ala Ala Leu Leu Glu Ala Gln Lys Arg Thr Tyr Lys Leu Arg Lys Glu 
            580                 585                 590         


Gln Leu Lys Glu Glu Leu Gln Glu Asn Pro Ser Thr Pro Lys Arg Glu 
        595                 600                 605             


Lys Ala Glu Trp Leu Leu Arg Gln Lys Glu Gln Leu Gln Gln Cys Gln 
    610                 615                 620                 


Ala Glu Glu Glu Ala Gly Leu Leu Arg Arg Gln Arg Gln Tyr Phe Glu 
625                 630                 635                 640 


Leu Gln Cys Arg Gln Tyr Lys Arg Lys Met Leu Leu Ala Arg His Ser 
                645                 650                 655     


Leu Asp Gln Asp Leu Leu Arg Glu Asp Leu Asn Lys Lys Gln Thr Gln 
            660                 665                 670         


Lys Asp Leu Glu Cys Ala Leu Leu Leu Arg Gln His Glu Ala Thr Arg 
        675                 680                 685             


Glu Leu Glu Leu Arg Gln Leu Gln Ala Val Gln Arg Thr Arg Ala Glu 
    690                 695                 700                 


Leu Thr Arg Leu Gln His Gln Thr Glu Leu Gly Asn Gln Leu Glu Tyr 
705                 710                 715                 720 


Asn Lys Arg Arg Glu Gln Glu Leu Arg Gln Lys His Ala Ala Gln Val 
                725                 730                 735     


Arg Gln Gln Pro Lys Ser Leu Lys Val Arg Ala Gly Gln Arg Pro Pro 
            740                 745                 750         


Gly Leu Pro Leu Pro Ile Pro Gly Ala Leu Gly Pro Pro Asn Thr Gly 
        755                 760                 765             


Thr Pro Ile Glu Gln Gln Pro Cys Ser Pro Gly Gln Glu Ala Val Leu 
    770                 775                 780                 


Asp Gln Arg Met Leu Gly Glu Glu Glu Glu Ala Val Gly Glu Arg Arg 
785                 790                 795                 800 


Ile Leu Gly Lys Glu Gly Ala Thr Leu Glu Pro Lys Gln Gln Arg Ile 
                805                 810                 815     


Leu Gly Glu Glu Ser Gly Ala Pro Ser Pro Ser Pro Gln Lys His Gly 
            820                 825                 830         


Ser Leu Val Asp Glu Glu Val Trp Gly Leu Pro Glu Glu Ile Glu Glu 
        835                 840                 845             


Leu Arg Val Pro Ser Leu Val Pro Gln Glu Arg Ser Ile Val Gly Gln 
    850                 855                 860                 


Glu Glu Ala Gly Thr Trp Ser Leu Trp Gly Lys Glu Asp Glu Ser Leu 
865                 870                 875                 880 


Leu Asp Glu Glu Phe Glu Leu Gly Trp Val Gln Gly Pro Ala Leu Thr 
                885                 890                 895     


Pro Val Pro Glu Glu Glu Glu Glu Glu Glu Glu Gly Ala Pro Ile Gly 
            900                 905                 910         


Thr Pro Arg Asp Pro Gly Asp Gly Cys Pro Ser Pro Asp Ile Pro Pro 
        915                 920                 925             


Glu Pro Pro Pro Thr His Leu Arg Pro Cys Pro Ala Ser Gln Leu Pro 
    930                 935                 940                 


Gly Leu Leu Ser His Gly Leu Leu Ala Gly Leu Ser Phe Ala Val Gly 
945                 950                 955                 960 


Ser Ser Ser Gly Leu Leu Pro Leu Leu Leu Leu Leu Leu Leu Pro Leu 
                965                 970                 975     


Leu Ala Ala Gln Gly Gly Gly Gly Leu Gln Ala Ala Leu Leu Ala Leu 
            980                 985                 990         


Glu Val Gly Leu Val Gly Leu Gly  Ala Ser Tyr Leu Leu  Leu Cys Thr 
        995                 1000                 1005             


Ala Leu  His Leu Pro Ser Ser  Leu Phe Leu Leu Leu  Ala Gln Gly 
    1010                 1015                 1020             


Thr Ala  Leu Gly Ala Val Leu  Gly Leu Ser Trp Arg  Arg Gly Leu 
    1025                 1030                 1035             


Met Gly  Val Pro Leu Gly Leu  Gly Ala Ala Trp Leu  Leu Ala Trp 
    1040                 1045                 1050             


Pro Gly  Leu Ala Leu Pro Leu  Val Ala Met Ala Ala  Gly Gly Arg 
    1055                 1060                 1065             


Trp Val  Arg Gln Gln Gly Pro  Arg Val Arg Arg Gly  Ile Ser Arg 
    1070                 1075                 1080             


Leu Trp  Leu Arg Val Leu Leu  Arg Leu Ser Pro Met  Ala Phe Arg 
    1085                 1090                 1095             


Ala Leu  Gln Gly Cys Gly Ala  Val Gly Asp Arg Gly  Leu Phe Ala 
    1100                 1105                 1110             


Leu Tyr  Pro Lys Thr Asn Lys  Asp Gly Phe Arg Ser  Arg Leu Pro 
    1115                 1120                 1125             


Val Pro  Gly Pro Arg Arg Arg  Asn Pro Arg Thr Thr  Gln His Pro 
    1130                 1135                 1140             


Leu Ala  Leu Leu Ala Arg Val  Trp Val Leu Cys Lys  Gly Trp Asn 
    1145                 1150                 1155             


Trp Arg  Leu Ala Arg Ala Ser  Gln Gly Leu Ala Ser  His Leu Pro 
    1160                 1165                 1170             


Pro Trp  Ala Ile His Thr Leu  Ala Ser Trp Gly Leu  Leu Arg Gly 
    1175                 1180                 1185             


Glu Arg  Pro Thr Arg Ile Pro  Arg Leu Leu Pro Arg  Ser Gln Arg 
    1190                 1195                 1200             


Gln Leu  Gly Pro Pro Ala Ser  Arg Gln Pro Leu Pro  Gly Thr Leu 
    1205                 1210                 1215             


Ala Gly  Arg Arg Ser Arg Thr  Arg Gln Ser Arg Ala  Leu Pro Pro 
    1220                 1225                 1230             


Trp Arg  
    1235 


<210>  4179
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  4179

Met Arg Lys Glu Leu Gln Leu Ser Leu Ser Val Thr Leu Leu Leu Val 
1               5                   10                  15      


Cys Gly Phe Leu Tyr Gln Phe Thr Leu Lys Ser Ser Cys Leu Phe Cys 
            20                  25                  30          


Leu Pro Ser Phe Lys Ser His Gln Gly Leu Glu Ala Leu Leu Ser His 
        35                  40                  45              


Arg Arg Gly Ile Val Phe Leu Glu Thr Ser Glu Arg Met Glu Pro Pro 
    50                  55                  60                  


His Leu Val Ser Cys Ser Val Glu Ser Ala Ala Lys Ile Tyr Pro Glu 
65                  70                  75                  80  


Trp Pro Val Val Phe Phe Met Lys Gly Leu Thr Asp Ser Thr Pro Met 
                85                  90                  95      


Pro Ser Asn Ser Thr Tyr Pro Ala Phe Ser Phe Leu Ser Ala Ile Asp 
            100                 105                 110         


Asn Val Phe Leu Phe Pro Leu Asp Met Lys Arg Leu Leu Glu Asp Thr 
        115                 120                 125             


Pro Leu Phe Ser Trp Tyr Asn Gln Ile Asn Ala Ser Ala Glu Arg Asn 
    130                 135                 140                 


Trp Leu His Ile Ser Ser Asp Ala Ser Arg Leu Ala Ile Ile Trp Lys 
145                 150                 155                 160 


Tyr Gly Gly Ile Tyr Met Asp Thr Asp Val Ile Ser Ile Arg Pro Ile 
                165                 170                 175     


Pro Glu Glu Asn Phe Leu Ala Ala Gln Ala Ser Arg Tyr Ser Ser Asn 
            180                 185                 190         


Gly Ile Phe Gly Phe Leu Pro His His Pro Phe Leu Trp Glu Cys Met 
        195                 200                 205             


Glu Asn Phe Val Glu His Tyr Asn Ser Ala Ile Trp Gly Asn Gln Gly 
    210                 215                 220                 


Pro Glu Leu Met Thr Arg Met Leu Arg Val Trp Cys Lys Leu Glu Asp 
225                 230                 235                 240 


Phe Gln Glu Val Ser Asp Leu Arg Cys Leu Asn Ile Ser Phe Leu His 
                245                 250                 255     


Pro Gln Arg Phe Tyr Pro Ile Ser Tyr Arg Glu Trp Arg Arg Tyr Tyr 
            260                 265                 270         


Glu Val Trp Asp Thr Glu Pro Ser Phe Asn Val Ser Tyr Ala Leu His 
        275                 280                 285             


Leu Trp Asn His Met Asn Gln Glu Gly Arg Ala Val Ile Arg Gly Ser 
    290                 295                 300                 


Asn Thr Leu Val Glu Asn Leu Tyr Arg Lys His Cys Pro Arg Thr Tyr 
305                 310                 315                 320 


Arg Asp Leu Ile Lys Gly Pro Glu Gly Ser Val Thr Gly Glu Leu Gly 
                325                 330                 335     


Pro Gly Asn Lys 
            340 


<210>  4180
<211>  977
<212>  PRT
<213>  Homo sapiens

<400>  4180

Met Ala Gln Phe Tyr Tyr Lys Arg Asn Val Asn Ala Pro Tyr Arg Asp 
1               5                   10                  15      


Arg Ile Pro Leu Arg Ile Val Arg Ala Glu Ser Glu Leu Ser Pro Ser 
            20                  25                  30          


Glu Lys Ala Tyr Leu Asn Ala Val Glu Lys Gly Asp Tyr Ala Ser Val 
        35                  40                  45              


Lys Lys Ser Leu Glu Glu Ala Glu Ile Tyr Phe Lys Ile Asn Ile Asn 
    50                  55                  60                  


Cys Ile Asp Pro Leu Gly Arg Thr Ala Leu Leu Ile Ala Ile Glu Asn 
65                  70                  75                  80  


Glu Asn Leu Glu Leu Ile Glu Leu Leu Leu Ser Phe Asn Val Tyr Val 
                85                  90                  95      


Gly Asp Ala Leu Leu His Ala Ile Arg Lys Glu Val Val Gly Ala Val 
            100                 105                 110         


Glu Leu Leu Leu Asn His Lys Lys Pro Ser Gly Glu Lys Gln Val Pro 
        115                 120                 125             


Pro Ile Leu Leu Asp Lys Gln Phe Ser Glu Phe Thr Pro Asp Ile Thr 
    130                 135                 140                 


Pro Ile Ile Leu Ala Ala His Thr Asn Asn Tyr Glu Ile Ile Lys Leu 
145                 150                 155                 160 


Leu Val Gln Lys Gly Val Ser Val Pro Arg Pro His Glu Val Arg Cys 
                165                 170                 175     


Asn Cys Val Glu Cys Val Ser Ser Ser Asp Val Asp Ser Leu Arg His 
            180                 185                 190         


Ser Arg Ser Arg Leu Asn Ile Tyr Lys Ala Leu Ala Ser Pro Ser Leu 
        195                 200                 205             


Ile Ala Leu Ser Ser Glu Asp Pro Phe Leu Thr Ala Phe Gln Leu Ser 
    210                 215                 220                 


Trp Glu Leu Gln Glu Leu Ser Lys Val Glu Asn Glu Phe Lys Ser Glu 
225                 230                 235                 240 


Tyr Glu Glu Leu Ser Arg Gln Cys Lys Gln Phe Ala Lys Asp Leu Leu 
                245                 250                 255     


Asp Gln Thr Arg Ser Ser Arg Glu Leu Glu Ile Ile Leu Asn Tyr Arg 
            260                 265                 270         


Asp Asp Asn Ser Leu Ile Glu Glu Gln Ser Gly Asn Asp Leu Ala Arg 
        275                 280                 285             


Leu Lys Leu Ala Ile Lys Tyr Arg Gln Lys Glu Phe Val Ala Gln Pro 
    290                 295                 300                 


Asn Cys Gln Gln Leu Leu Ala Ser Arg Trp Tyr Asp Glu Phe Pro Gly 
305                 310                 315                 320 


Trp Arg Arg Arg His Trp Ala Val Lys Met Val Thr Cys Phe Ile Ile 
                325                 330                 335     


Gly Leu Leu Phe Pro Val Phe Ser Val Cys Tyr Leu Ile Ala Pro Lys 
            340                 345                 350         


Ser Pro Leu Gly Leu Phe Ile Arg Lys Pro Phe Ile Lys Phe Ile Cys 
        355                 360                 365             


His Thr Ala Ser Tyr Leu Thr Phe Leu Phe Leu Leu Leu Leu Ala Ser 
    370                 375                 380                 


Gln His Ile Asp Arg Ser Asp Leu Asn Arg Gln Gly Pro Pro Pro Thr 
385                 390                 395                 400 


Ile Val Glu Trp Met Ile Leu Pro Trp Val Leu Gly Phe Ile Trp Gly 
                405                 410                 415     


Glu Ile Lys Gln Met Trp Asp Gly Gly Leu Gln Asp Tyr Ile His Asp 
            420                 425                 430         


Trp Trp Asn Leu Met Asp Phe Val Met Asn Ser Leu Tyr Leu Ala Thr 
        435                 440                 445             


Ile Ser Leu Lys Ile Val Ala Phe Val Lys Tyr Ser Ala Leu Asn Pro 
    450                 455                 460                 


Arg Glu Ser Trp Asp Met Trp His Pro Thr Leu Val Ala Glu Ala Leu 
465                 470                 475                 480 


Phe Ala Ile Ala Asn Ile Phe Ser Ser Leu Arg Leu Ile Ser Leu Phe 
                485                 490                 495     


Thr Ala Asn Ser His Leu Gly Pro Leu Gln Ile Ser Leu Gly Arg Met 
            500                 505                 510         


Leu Leu Asp Ile Leu Lys Phe Leu Phe Ile Tyr Cys Leu Val Leu Leu 
        515                 520                 525             


Ala Phe Ala Asn Gly Leu Asn Gln Leu Tyr Phe Tyr Tyr Glu Glu Thr 
    530                 535                 540                 


Lys Gly Leu Thr Cys Lys Gly Ile Arg Cys Glu Lys Gln Asn Asn Ala 
545                 550                 555                 560 


Phe Ser Thr Leu Phe Glu Thr Leu Gln Ser Leu Phe Trp Ser Ile Phe 
                565                 570                 575     


Gly Leu Ile Asn Leu Tyr Val Thr Asn Val Lys Ala Gln His Glu Phe 
            580                 585                 590         


Thr Glu Phe Val Gly Ala Thr Met Phe Gly Thr Tyr Asn Val Ile Ser 
        595                 600                 605             


Leu Val Val Leu Leu Asn Met Leu Ile Ala Met Met Asn Asn Ser Tyr 
    610                 615                 620                 


Gln Leu Ile Ala Asp His Ala Asp Ile Glu Trp Lys Phe Ala Arg Thr 
625                 630                 635                 640 


Lys Leu Trp Met Ser Tyr Phe Glu Glu Gly Gly Thr Leu Pro Thr Pro 
                645                 650                 655     


Phe Asn Val Ile Pro Ser Pro Lys Ser Leu Trp Tyr Leu Ile Lys Trp 
            660                 665                 670         


Ile Trp Thr His Leu Cys Lys Lys Lys Met Arg Arg Lys Pro Glu Ser 
        675                 680                 685             


Phe Gly Thr Ile Gly Arg Arg Ala Ala Asp Asn Leu Arg Arg His His 
    690                 695                 700                 


Gln Tyr Gln Glu Val Met Arg Asn Leu Val Lys Arg Tyr Val Ala Ala 
705                 710                 715                 720 


Met Ile Arg Asp Ala Lys Thr Glu Glu Gly Leu Thr Glu Glu Asn Phe 
                725                 730                 735     


Lys Glu Leu Lys Gln Asp Ile Ser Ser Phe Arg Phe Glu Val Leu Gly 
            740                 745                 750         


Leu Leu Arg Gly Ser Lys Leu Ser Thr Ile Gln Ser Ala Asn Ala Ser 
        755                 760                 765             


Lys Glu Ser Ser Asn Ser Ala Asp Ser Asp Glu Lys Ser Asp Ser Glu 
    770                 775                 780                 


Gly Asn Ser Lys Asp Lys Lys Lys Asn Phe Ser Leu Phe Asp Leu Thr 
785                 790                 795                 800 


Thr Leu Ile His Pro Arg Ser Ala Ala Ile Ala Ser Glu Arg His Asn 
                805                 810                 815     


Ile Ser Asn Gly Ser Ala Leu Val Val Gln Glu Pro Pro Arg Glu Lys 
            820                 825                 830         


Gln Arg Lys Val Asn Phe Val Thr Asp Ile Lys Asn Phe Gly Leu Phe 
        835                 840                 845             


His Arg Arg Ser Lys Gln Asn Ala Ala Glu Gln Asn Ala Asn Gln Ile 
    850                 855                 860                 


Phe Ser Val Ser Glu Glu Val Ala Arg Gln Gln Ala Ala Gly Pro Leu 
865                 870                 875                 880 


Glu Arg Asn Ile Gln Leu Glu Ser Arg Gly Leu Ala Ser Arg Gly Asp 
                885                 890                 895     


Leu Ser Ile Pro Gly Leu Ser Glu Gln Cys Val Leu Val Asp His Arg 
            900                 905                 910         


Glu Arg Asn Thr Asp Thr Leu Gly Leu Gln Val Gly Lys Arg Val Cys 
        915                 920                 925             


Pro Phe Lys Ser Glu Lys Val Val Val Glu Asp Thr Val Pro Ile Ile 
    930                 935                 940                 


Pro Lys Glu Lys His Ala Lys Glu Glu Asp Ser Ser Ile Asp Tyr Asp 
945                 950                 955                 960 


Leu Asn Leu Pro Asp Thr Val Thr His Glu Asp Tyr Val Thr Thr Arg 
                965                 970                 975     


Leu 
    


<210>  4181
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  4181

Met Gly Ser Asn Ser Gly Gln Ala Gly Arg His Ile Tyr Lys Ser Leu 
1               5                   10                  15      


Ala Asp Asp Gly Pro Phe Asp Ser Val Glu Pro Pro Lys Arg Pro Thr 
            20                  25                  30          


Ser Arg Leu Ile Met His Ser Met Ala Met Phe Gly Arg Glu Phe Cys 
        35                  40                  45              


Tyr Ala Val Glu Ala Ala Tyr Val Thr Pro Val Leu Leu Ser Val Gly 
    50                  55                  60                  


Leu Pro Ser Ser Leu Tyr Ser Ile Val Trp Phe Leu Ser Pro Ile Leu 
65                  70                  75                  80  


Gly Phe Leu Leu Gln Pro Val Val Gly Ser Ala Ser Asp His Cys Arg 
                85                  90                  95      


Ser Arg Trp Gly Arg Arg Arg Pro Tyr Ile Leu Thr Leu Gly Val Met 
            100                 105                 110         


Met Leu Val Gly Met Ala Leu Tyr Leu Asn Gly Ala Thr Val Val Ala 
        115                 120                 125             


Ala Leu Ile Ala Asn Pro Arg Arg Lys Leu Val Trp Ala Ile Ser Val 
    130                 135                 140                 


Thr Met Ile Gly Val Val Leu Phe Asp Phe Ala Ala Asp Phe Ile Asp 
145                 150                 155                 160 


Gly Pro Ile Lys Ala Tyr Leu Phe Asp Val Cys Ser His Gln Asp Lys 
                165                 170                 175     


Glu Lys Gly Leu His Tyr His Ala Leu Phe Thr Gly Phe Gly Gly Ala 
            180                 185                 190         


Leu Gly Tyr Leu Leu Gly Ala Ile Asp Trp Ala His Leu Glu Leu Gly 
        195                 200                 205             


Arg Leu Leu Gly Thr Glu Phe Gln Val Met Phe Phe Phe Ser Ala Leu 
    210                 215                 220                 


Val Leu Thr Leu Cys Phe Thr Val His Leu Cys Ser Ile Ser Glu Ala 
225                 230                 235                 240 


Pro Leu Thr Glu Val Ala Lys Gly Ile Pro Pro Gln Gln Thr Pro Gln 
                245                 250                 255     


Asp Pro Pro Leu Ser Ser Asp Gly Met Tyr Glu Tyr Gly Ser Ile Glu 
            260                 265                 270         


Lys Val Lys Asn Gly Tyr Val Asn Pro Glu Leu Ala Met Gln Gly Ala 
        275                 280                 285             


Lys Asn Lys Asn His Ala Glu Gln Thr Arg Arg Ala Met Thr Leu Lys 
    290                 295                 300                 


Ser Leu Leu Arg Ala Leu Val Asn Met Pro Pro His Tyr Arg Tyr Leu 
305                 310                 315                 320 


Cys Ile Ser His Leu Ile Gly Trp Thr Ala Phe Leu Ser Asn Met Leu 
                325                 330                 335     


Phe Phe Thr Asp Phe Met Gly Gln Ile Val Tyr Arg Gly Asp Pro Tyr 
            340                 345                 350         


Ser Ala His Asn Ser Thr Glu Phe Leu Ile Tyr Glu Arg Gly Val Glu 
        355                 360                 365             


Val Gly Cys Trp Gly Phe Cys Ile Asn Ser Val Phe Ser Ser Leu Tyr 
    370                 375                 380                 


Ser Tyr Phe Gln Lys Val Leu Val Ser Tyr Ile Gly Leu Lys Gly Leu 
385                 390                 395                 400 


Tyr Phe Thr Gly Tyr Leu Leu Phe Gly Leu Gly Thr Gly Phe Ile Gly 
                405                 410                 415     


Leu Phe Pro Asn Val Tyr Ser Thr Leu Val Leu Cys Ser Leu Phe Gly 
            420                 425                 430         


Val Met Ser Ser Thr Leu Tyr Thr Val Pro Phe Asn Leu Ile Thr Glu 
        435                 440                 445             


Tyr His Arg Glu Glu Glu Lys Glu Arg Gln Gln Ala Pro Gly Gly Asp 
    450                 455                 460                 


Pro Asp Asn Ser Val Arg Gly Lys Gly Met Asp Cys Ala Thr Leu Thr 
465                 470                 475                 480 


Cys Met Val Gln Leu Ala Gln Ile Leu Val Gly Gly Gly Leu Gly Phe 
                485                 490                 495     


Leu Val Asn Thr Ala Gly Thr Val Val Val Val Val Ile Thr Ala Ser 
            500                 505                 510         


Ala Val Ala Leu Ile Gly Cys Cys Phe Val Ala Leu Phe Val Arg Tyr 
        515                 520                 525             


Val Asp 
    530 


<210>  4182
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  4182

Met Thr Ser Glu Ile Thr Tyr Ala Glu Val Arg Phe Lys Asn Glu Phe 
1               5                   10                  15      


Lys Ser Ser Gly Ile Asn Thr Ala Ser Ser Ala Ala Ser Lys Glu Arg 
            20                  25                  30          


Thr Ala Pro His Lys Ser Asn Thr Gly Phe Pro Lys Leu Leu Cys Ala 
        35                  40                  45              


Ser Leu Leu Ile Phe Phe Leu Leu Leu Ala Ile Ser Phe Phe Ile Ala 
    50                  55                  60                  


Phe Val Ile Phe Phe Gln Lys Tyr Ser Gln Leu Leu Glu Lys Lys Thr 
65                  70                  75                  80  


Thr Lys Glu Leu Val His Thr Thr Leu Glu Cys Val Lys Lys Asn Met 
                85                  90                  95      


Pro Val Glu Glu Thr Ala Trp Ser Cys Cys Pro Lys Asn Trp Lys Ser 
            100                 105                 110         


Phe Ser Ser Asn Cys Tyr Phe Ile Ser Thr Glu Ser Ala Ser Trp Gln 
        115                 120                 125             


Asp Ser Glu Lys Asp Cys Ala Arg Met Glu Ala His Leu Leu Val Ile 
    130                 135                 140                 


Asn Thr Gln Glu Glu Gln Asp Phe Ile Phe Gln Asn Leu Gln Glu Glu 
145                 150                 155                 160 


Ser Ala Tyr Phe Val Gly Leu Ser Asp Pro Glu Gly Gln Arg His Trp 
                165                 170                 175     


Gln Trp Val Asp Gln Thr Pro Tyr Asn Glu Ser Ser Thr Phe Trp His 
            180                 185                 190         


Pro Arg Glu Pro Ser Asp Pro Asn Glu Arg Cys Val Val Leu Asn Phe 
        195                 200                 205             


Arg Lys Ser Pro Lys Arg Trp Gly Trp Asn Asp Val Asn Cys Leu Gly 
    210                 215                 220                 


Pro Gln Arg Ser Val Cys Glu Met Met Lys Ile His Leu 
225                 230                 235         


<210>  4183
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  4183

Met Val Leu Trp Glu Ser Pro Arg Gln Cys Ser Ser Trp Thr Leu Cys 
1               5                   10                  15      


Glu Gly Phe Cys Trp Leu Leu Leu Leu Pro Val Met Leu Leu Ile Val 
            20                  25                  30          


Ala Arg Pro Val Lys Leu Ala Ala Phe Pro Thr Ser Leu Ser Asp Cys 
        35                  40                  45              


Gln Thr Pro Thr Gly Trp Asn Cys Ser Gly Tyr Asp Asp Arg Glu Asn 
    50                  55                  60                  


Asp Leu Phe Leu Cys Asp Thr Asn Thr Cys Lys Phe Asp Gly Glu Cys 
65                  70                  75                  80  


Leu Arg Ile Gly Asp Thr Val Thr Cys Val Cys Gln Phe Lys Cys Asn 
                85                  90                  95      


Asn Asp Tyr Val Pro Val Cys Gly Ser Asn Gly Glu Ser Tyr Gln Asn 
            100                 105                 110         


Glu Cys Tyr Leu Arg Gln Ala Ala Cys Lys Gln Gln Ser Glu Ile Leu 
        115                 120                 125             


Val Val Ser Glu Gly Ser Cys Ala Thr Asp Ala Gly Ser Gly Ser Gly 
    130                 135                 140                 


Asp Gly Val His Glu Gly Ser Gly Glu Thr Ser Gln Lys Glu Thr Ser 
145                 150                 155                 160 


Thr Cys Asp Ile Cys Gln Phe Gly Ala Glu Cys Asp Glu Asp Ala Glu 
                165                 170                 175     


Asp Val Trp Cys Val Cys Asn Ile Asp Cys Ser Gln Thr Asn Phe Asn 
            180                 185                 190         


Pro Leu Cys Ala Ser Asp Gly Lys Ser Tyr Asp Asn Ala Cys Gln Ile 
        195                 200                 205             


Lys Glu Ala Ser Cys Gln Lys Gln Glu Lys Ile Glu Val Met Ser Leu 
    210                 215                 220                 


Gly Arg Cys Gln Asp Asn Thr Thr Thr Thr Thr Lys Ser Glu Asp Gly 
225                 230                 235                 240 


His Tyr Ala Arg Thr Asp Tyr Ala Glu Asn Ala Asn Lys Leu Glu Glu 
                245                 250                 255     


Ser Ala Arg Glu His His Ile Pro Cys Pro Glu His Tyr Asn Gly Phe 
            260                 265                 270         


Cys Met His Gly Lys Cys Glu His Ser Ile Asn Met Gln Glu Pro Ser 
        275                 280                 285             


Cys Arg Cys Asp Ala Gly Tyr Thr Gly Gln His Cys Glu Lys Lys Asp 
    290                 295                 300                 


Tyr Ser Val Leu Tyr Val Val Pro Gly Pro Val Arg Phe Gln Tyr Val 
305                 310                 315                 320 


Leu Ile Ala Ala Val Ile Gly Thr Ile Gln Ile Ala Val Ile Cys Val 
                325                 330                 335     


Val Val Leu Cys Ile Thr Arg Lys Cys Pro Arg Ser Asn Arg Ile His 
            340                 345                 350         


Arg Gln Lys Gln Asn Thr Gly His Tyr Ser Ser Asp Asn Thr Thr Arg 
        355                 360                 365             


Ala Ser Thr Arg Leu Ile 
    370                 


<210>  4184
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  4184

Met Asn Ser Arg Thr Ala Ser Ala Arg Gly Trp Phe Ser Ser Arg Pro 
1               5                   10                  15      


Pro Thr Ser Glu Ser Asp Leu Glu Pro Ala Thr Asp Gly Pro Ala Ser 
            20                  25                  30          


Glu Thr Thr Thr Leu Ser Pro Glu Ala Thr Thr Phe Asn Asp Thr Arg 
        35                  40                  45              


Ile Pro Asp Ala Ala Gly Gly Thr Ala Gly Val Gly Thr Met Leu Leu 
    50                  55                  60                  


Ser Phe Gly Ile Ile Thr Val Ile Gly Leu Ala Val Ala Leu Val Leu 
65                  70                  75                  80  


Tyr Ile Arg Lys Lys Lys Arg Leu Glu Lys Leu Arg His Gln Leu Met 
                85                  90                  95      


Pro Met Tyr Asn Phe Asp Pro Thr Glu Glu Gln Asp Glu Leu Glu Gln 
            100                 105                 110         


Glu Leu Leu Glu His Gly Arg Asp Ala Ala Ser Val Gln Ala Ala Thr 
        115                 120                 125             


Ser Val Gln Ala Met Gln Gly Lys Thr Thr Leu Pro Ser Gln Gly Pro 
    130                 135                 140                 


Leu Gln Arg Pro Ser Arg Leu Val Phe Thr Asp Val Ala Asn Ala Ile 
145                 150                 155                 160 


His Ala 
        


<210>  4185
<211>  699
<212>  PRT
<213>  Homo sapiens

<400>  4185

Met Ala Ala Cys Glu Gly Arg Arg Ser Gly Ala Leu Gly Ser Ser Gln 
1               5                   10                  15      


Ser Asp Phe Leu Thr Pro Pro Val Gly Gly Ala Pro Trp Ala Val Ala 
            20                  25                  30          


Thr Thr Val Val Met Tyr Pro Pro Pro Pro Pro Pro Pro His Arg Asp 
        35                  40                  45              


Phe Ile Ser Val Thr Leu Ser Phe Gly Glu Asn Tyr Asp Asn Ser Lys 
    50                  55                  60                  


Ser Trp Arg Arg Arg Ser Cys Trp Arg Lys Trp Lys Gln Leu Ser Arg 
65                  70                  75                  80  


Leu Gln Arg Asn Met Ile Leu Phe Leu Leu Ala Phe Leu Leu Phe Cys 
                85                  90                  95      


Gly Leu Leu Phe Tyr Ile Asn Leu Ala Asp His Trp Lys Ala Leu Ala 
            100                 105                 110         


Phe Arg Leu Glu Glu Glu Gln Lys Met Arg Pro Glu Ile Ala Gly Leu 
        115                 120                 125             


Lys Pro Ala Asn Pro Pro Val Leu Pro Ala Pro Gln Lys Ala Asp Thr 
    130                 135                 140                 


Asp Pro Glu Asn Leu Pro Glu Ile Ser Ser Gln Lys Thr Gln Arg His 
145                 150                 155                 160 


Ile Gln Arg Gly Pro Pro His Leu Gln Ile Arg Pro Pro Ser Gln Asp 
                165                 170                 175     


Leu Lys Asp Gly Thr Gln Glu Glu Ala Thr Lys Arg Gln Glu Ala Pro 
            180                 185                 190         


Val Asp Pro Arg Pro Glu Gly Asp Pro Gln Arg Thr Val Ile Ser Trp 
        195                 200                 205             


Arg Gly Ala Val Ile Glu Pro Glu Gln Gly Thr Glu Leu Pro Ser Arg 
    210                 215                 220                 


Arg Ala Glu Val Pro Thr Lys Pro Pro Leu Pro Pro Ala Arg Thr Gln 
225                 230                 235                 240 


Gly Thr Pro Val His Leu Asn Tyr Arg Gln Lys Gly Val Ile Asp Val 
                245                 250                 255     


Phe Leu His Ala Trp Lys Gly Tyr Arg Lys Phe Ala Trp Gly His Asp 
            260                 265                 270         


Glu Leu Lys Pro Val Ser Arg Ser Phe Ser Glu Trp Phe Gly Leu Gly 
        275                 280                 285             


Leu Thr Leu Ile Asp Ala Leu Asp Thr Met Trp Ile Leu Gly Leu Arg 
    290                 295                 300                 


Lys Glu Phe Glu Glu Ala Arg Lys Trp Val Ser Lys Lys Leu His Phe 
305                 310                 315                 320 


Glu Lys Asp Val Asp Val Asn Leu Phe Glu Ser Thr Ile Arg Ile Leu 
                325                 330                 335     


Gly Gly Leu Leu Ser Ala Tyr His Leu Ser Gly Asp Ser Leu Phe Leu 
            340                 345                 350         


Arg Lys Ala Glu Asp Phe Gly Asn Arg Leu Met Pro Ala Phe Arg Thr 
        355                 360                 365             


Pro Ser Lys Ile Pro Tyr Ser Asp Val Asn Ile Gly Thr Gly Val Ala 
    370                 375                 380                 


His Pro Pro Arg Trp Thr Ser Asp Ser Thr Val Ala Glu Val Thr Ser 
385                 390                 395                 400 


Ile Gln Leu Glu Phe Arg Glu Leu Ser Arg Leu Thr Gly Asp Lys Lys 
                405                 410                 415     


Phe Gln Glu Ala Val Glu Lys Val Thr Gln His Ile His Gly Leu Ser 
            420                 425                 430         


Gly Lys Lys Asp Gly Leu Val Pro Met Phe Ile Asn Thr His Ser Gly 
        435                 440                 445             


Leu Phe Thr His Leu Gly Val Phe Thr Leu Gly Ala Arg Ala Asp Ser 
    450                 455                 460                 


Tyr Tyr Glu Tyr Leu Leu Lys Gln Trp Ile Gln Gly Gly Lys Gln Glu 
465                 470                 475                 480 


Thr Gln Leu Leu Glu Asp Tyr Val Glu Ala Ile Glu Gly Val Arg Thr 
                485                 490                 495     


His Leu Leu Arg His Ser Glu Pro Ser Lys Leu Thr Phe Val Gly Glu 
            500                 505                 510         


Leu Ala His Gly Arg Phe Ser Ala Lys Met Asp His Leu Val Cys Phe 
        515                 520                 525             


Leu Pro Gly Thr Leu Ala Leu Gly Val Tyr His Gly Leu Pro Ala Ser 
    530                 535                 540                 


His Met Glu Leu Ala Gln Glu Leu Met Glu Thr Cys Tyr Gln Met Asn 
545                 550                 555                 560 


Arg Gln Met Glu Thr Gly Leu Ser Pro Glu Ile Val His Phe Asn Leu 
                565                 570                 575     


Tyr Pro Gln Pro Gly Arg Arg Asp Val Glu Val Lys Pro Ala Asp Arg 
            580                 585                 590         


His Asn Leu Leu Arg Pro Glu Thr Val Glu Ser Leu Phe Tyr Leu Tyr 
        595                 600                 605             


Arg Val Thr Gly Asp Arg Lys Tyr Gln Asp Trp Gly Trp Glu Ile Leu 
    610                 615                 620                 


Gln Ser Phe Ser Arg Phe Thr Arg Val Pro Ser Gly Gly Tyr Ser Ser 
625                 630                 635                 640 


Ile Asn Asn Val Gln Asp Pro Gln Lys Pro Glu Pro Arg Asp Lys Met 
                645                 650                 655     


Glu Ser Phe Phe Leu Gly Glu Thr Leu Lys Tyr Leu Phe Leu Leu Phe 
            660                 665                 670         


Ser Asp Asp Pro Asn Leu Leu Ser Leu Asp Ala Tyr Val Phe Asn Thr 
        675                 680                 685             


Glu Ala His Pro Leu Pro Ile Trp Thr Pro Ala 
    690                 695                 


<210>  4186
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  4186

Met Asn Ser Arg Arg Arg Glu Pro Ile Thr Leu Gln Asp Pro Glu Ala 
1               5                   10                  15      


Lys Tyr Pro Leu Pro Leu Ile Glu Lys Glu Lys Ile Ser His Asn Thr 
            20                  25                  30          


Arg Arg Phe Arg Phe Gly Leu Pro Ser Pro Asp His Val Leu Gly Leu 
        35                  40                  45              


Pro Val Gly Asn Tyr Val Gln Leu Leu Ala Lys Ile Asp Asn Glu Leu 
    50                  55                  60                  


Val Val Arg Ala Tyr Thr Pro Val Ser Ser Asp Asp Asp Arg Gly Phe 
65                  70                  75                  80  


Val Asp Leu Ile Ile Lys Ile Tyr Phe Lys Asn Val His Pro Gln Tyr 
                85                  90                  95      


Pro Glu Gly Gly Lys Met Thr Gln Tyr Leu Glu Asn Met Lys Ile Gly 
            100                 105                 110         


Glu Thr Ile Phe Phe Arg Gly Pro Arg Gly Arg Leu Phe Tyr His Gly 
        115                 120                 125             


Pro Gly Asn Leu Gly Ile Arg Pro Asp Gln Thr Ser Glu Pro Lys Lys 
    130                 135                 140                 


Thr Leu Ala Asp His Leu Gly Met Ile Ala Gly Gly Thr Gly Ile Thr 
145                 150                 155                 160 


Pro Met Leu Gln Leu Ile Arg His Ile Thr Lys Asp Pro Ser Asp Arg 
                165                 170                 175     


Thr Arg Met Ser Leu Ile Phe Ala Asn Gln Thr Glu Glu Asp Ile Leu 
            180                 185                 190         


Val Arg Lys Glu Leu Glu Glu Ile Ala Arg Thr His Pro Asp Gln Phe 
        195                 200                 205             


Asn Leu Trp Tyr Thr Leu Asp Arg Pro Pro Ile Gly Trp Lys Tyr Ser 
    210                 215                 220                 


Ser Gly Phe Val Thr Ala Asp Met Ile Lys Glu His Leu Pro Pro Pro 
225                 230                 235                 240 


Ala Lys Ser Thr Leu Ile Leu Val Cys Gly Pro Pro Pro Leu Ile Gln 
                245                 250                 255     


Thr Ala Ala His Pro Asn Leu Glu Lys Leu Gly Tyr Thr Gln Asp Met 
            260                 265                 270         


Ile Phe Thr Tyr 
        275     


<210>  4187
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  4187

Met Gly Phe Trp Ile Leu Ala Ile Leu Thr Ile Leu Met Tyr Ser Thr 
1               5                   10                  15      


Ala Ala Lys Phe Ser Lys Gln Ser Trp Gly Leu Glu Asn Glu Ala Leu 
            20                  25                  30          


Ile Val Arg Cys Pro Arg Gln Gly Lys Pro Ser Tyr Thr Val Asp Trp 
        35                  40                  45              


Tyr Tyr Ser Gln Thr Asn Lys Ser Ile Pro Thr Gln Glu Arg Asn Arg 
    50                  55                  60                  


Val Phe Ala Ser Gly Gln Leu Leu Lys Phe Leu Pro Ala Ala Val Ala 
65                  70                  75                  80  


Asp Ser Gly Ile Tyr Thr Cys Ile Val Arg Ser Pro Thr Phe Asn Arg 
                85                  90                  95      


Thr Gly Tyr Ala Asn Val Thr Ile Tyr Lys Lys Gln Ser Asp Cys Asn 
            100                 105                 110         


Val Pro Asp Tyr Leu Met Tyr Ser Thr Val Ser Gly Ser Glu Lys Asn 
        115                 120                 125             


Ser Lys Ile Tyr Cys Pro Thr Ile Asp Leu Tyr Asn Trp Thr Ala Pro 
    130                 135                 140                 


Leu Glu Trp Phe Lys Asn Cys Gln Ala Leu Gln Gly Ser Arg Tyr Arg 
145                 150                 155                 160 


Ala His Lys Ser Phe Leu Val Ile Asp Asn Val Met Thr Glu Asp Ala 
                165                 170                 175     


Gly Asp Tyr Thr Cys Lys Phe Ile His Asn Glu Asn Gly Ala Asn Tyr 
            180                 185                 190         


Ser Val Thr Ala Thr Arg Ser Phe Thr Val Lys Asp Glu Gln Gly Phe 
        195                 200                 205             


Ser Leu Phe Pro Val Ile Gly Ala Pro Ala Gln Asn Glu Ile Lys Glu 
    210                 215                 220                 


Val Glu Ile Gly Lys Asn Ala Asn Leu Thr Cys Ser Ala Cys Phe Gly 
225                 230                 235                 240 


Lys Gly Thr Gln Phe Leu Ala Ala Val Leu Trp Gln Leu Asn Gly Thr 
                245                 250                 255     


Lys Ile Thr Asp Phe Gly Glu Pro Arg Ile Gln Gln Glu Glu Gly Gln 
            260                 265                 270         


Asn Gln Ser Phe Ser Asn Gly Leu Ala Cys Leu Asp Met Val Leu Arg 
        275                 280                 285             


Ile Ala Asp Val Lys Glu Glu Asp Leu Leu Leu Gln Tyr Asp Cys Leu 
    290                 295                 300                 


Ala Leu Asn Leu His Gly Leu Arg Arg His Thr Val Arg Leu Ser Arg 
305                 310                 315                 320 


Lys Asn Pro Ile Asp His His Ser Ile Tyr Cys Ile Ile Ala Val Cys 
                325                 330                 335     


Ser Val Phe Leu Met Leu Ile Asn Val Leu Val Ile Ile Leu Lys Met 
            340                 345                 350         


Phe Trp Ile Glu Ala Thr Leu Leu Trp Arg Asp Ile Ala Lys Pro Tyr 
        355                 360                 365             


Lys Thr Arg Asn Asp Gly Lys Leu Tyr Asp Ala Tyr Val Val Tyr Pro 
    370                 375                 380                 


Arg Asn Tyr Lys Ser Ser Thr Asp Gly Ala Ser Arg Val Glu His Phe 
385                 390                 395                 400 


Val His Gln Ile Leu Pro Asp Val Leu Glu Asn Lys Cys Gly Tyr Thr 
                405                 410                 415     


Leu Cys Ile Tyr Gly Arg Asp Met Leu Pro Gly Glu Asp Val Val Thr 
            420                 425                 430         


Ala Val Glu Thr Asn Ile Arg Lys Ser Arg Arg His Ile Phe Ile Leu 
        435                 440                 445             


Thr Pro Gln Ile Thr His Asn Lys Glu Phe Ala Tyr Glu Gln Glu Val 
    450                 455                 460                 


Ala Leu His Cys Ala Leu Ile Gln Asn Asp Ala Lys Val Ile Leu Ile 
465                 470                 475                 480 


Glu Met Glu Ala Leu Ser Glu Leu Asp Met Leu Gln Ala Glu Ala Leu 
                485                 490                 495     


Gln Asp Ser Leu Gln His Leu Met Lys Val Gln Gly Thr Ile Lys Trp 
            500                 505                 510         


Arg Glu Asp His Ile Ala Asn Lys Arg Ser Leu Asn Ser Lys Phe Trp 
        515                 520                 525             


Lys His Val Arg Tyr Gln Met Pro Val Pro Ser Lys Ile Pro Arg Lys 
    530                 535                 540                 


Ala Ser Ser Leu Thr Pro Leu Ala Ala Gln Lys Gln 
545                 550                 555     


<210>  4188
<211>  739
<212>  PRT
<213>  Homo sapiens

<400>  4188

Met Asp Ala Leu Lys Pro Pro Cys Leu Trp Arg Asn His Glu Arg Gly 
1               5                   10                  15      


Lys Lys Asp Arg Asp Ser Cys Gly Arg Lys Asn Ser Glu Pro Gly Ser 
            20                  25                  30          


Pro His Ser Leu Glu Ala Leu Arg Asp Ala Ala Pro Ser Gln Gly Leu 
        35                  40                  45              


Asn Phe Leu Leu Leu Phe Thr Lys Met Leu Phe Ile Phe Asn Phe Leu 
    50                  55                  60                  


Phe Ser Pro Leu Pro Thr Pro Ala Leu Ile Cys Ile Leu Thr Phe Gly 
65                  70                  75                  80  


Ala Ala Ile Phe Leu Trp Leu Ile Thr Arg Pro Gln Pro Val Leu Pro 
                85                  90                  95      


Leu Leu Asp Leu Asn Asn Gln Ser Val Gly Ile Glu Gly Gly Ala Arg 
            100                 105                 110         


Lys Gly Val Ser Gln Lys Asn Asn Asp Leu Thr Ser Cys Cys Phe Ser 
        115                 120                 125             


Asp Ala Lys Thr Met Tyr Glu Val Phe Gln Arg Gly Leu Ala Val Ser 
    130                 135                 140                 


Asp Asn Gly Pro Cys Leu Gly Tyr Arg Lys Pro Asn Gln Pro Tyr Arg 
145                 150                 155                 160 


Trp Leu Ser Tyr Lys Gln Val Ser Asp Arg Ala Glu Tyr Leu Gly Ser 
                165                 170                 175     


Cys Leu Leu His Lys Gly Tyr Lys Ser Ser Pro Asp Gln Phe Val Gly 
            180                 185                 190         


Ile Phe Ala Gln Asn Arg Pro Glu Trp Ile Ile Ser Glu Leu Ala Cys 
        195                 200                 205             


Tyr Thr Tyr Ser Met Val Ala Val Pro Leu Tyr Asp Thr Leu Gly Pro 
    210                 215                 220                 


Glu Ala Ile Val His Ile Val Asn Lys Ala Asp Ile Ala Met Val Ile 
225                 230                 235                 240 


Cys Asp Thr Pro Gln Lys Ala Leu Val Leu Ile Gly Asn Val Glu Lys 
                245                 250                 255     


Gly Phe Thr Pro Ser Leu Lys Val Ile Ile Leu Met Asp Pro Phe Asp 
            260                 265                 270         


Asp Asp Leu Lys Gln Arg Gly Glu Lys Ser Gly Ile Glu Ile Leu Ser 
        275                 280                 285             


Leu Tyr Asp Ala Glu Asn Leu Gly Lys Glu His Phe Arg Lys Pro Val 
    290                 295                 300                 


Pro Pro Ser Pro Glu Asp Leu Ser Val Ile Cys Phe Thr Ser Gly Thr 
305                 310                 315                 320 


Thr Gly Asp Pro Lys Gly Ala Met Ile Thr His Gln Asn Ile Val Ser 
                325                 330                 335     


Asn Ala Ala Ala Phe Leu Lys Cys Val Glu His Ala Tyr Glu Pro Thr 
            340                 345                 350         


Pro Asp Asp Val Ala Ile Ser Tyr Leu Pro Leu Ala His Met Phe Glu 
        355                 360                 365             


Arg Ile Val Gln Ala Val Val Tyr Ser Cys Gly Ala Arg Val Gly Phe 
    370                 375                 380                 


Phe Gln Gly Asp Ile Arg Leu Leu Ala Asp Asp Met Lys Thr Leu Lys 
385                 390                 395                 400 


Pro Thr Leu Phe Pro Ala Val Pro Arg Leu Leu Asn Arg Ile Tyr Asp 
                405                 410                 415     


Lys Val Gln Asn Glu Ala Lys Thr Pro Leu Lys Lys Phe Leu Leu Lys 
            420                 425                 430         


Leu Ala Val Ser Ser Lys Phe Lys Glu Leu Gln Lys Gly Ile Ile Arg 
        435                 440                 445             


His Asp Ser Phe Trp Asp Lys Leu Ile Phe Ala Lys Ile Gln Asp Ser 
    450                 455                 460                 


Leu Gly Gly Arg Val Arg Val Ile Val Thr Gly Ala Ala Pro Met Ser 
465                 470                 475                 480 


Thr Ser Val Met Thr Phe Phe Arg Ala Ala Met Gly Cys Gln Val Tyr 
                485                 490                 495     


Glu Ala Tyr Gly Gln Thr Glu Cys Thr Gly Gly Cys Thr Phe Thr Leu 
            500                 505                 510         


Pro Gly Asp Trp Thr Ser Gly His Val Gly Val Pro Leu Ala Cys Asn 
        515                 520                 525             


Tyr Val Lys Leu Glu Asp Val Ala Asp Met Asn Tyr Phe Thr Val Asn 
    530                 535                 540                 


Asn Glu Gly Glu Val Cys Ile Lys Gly Thr Asn Val Phe Lys Gly Tyr 
545                 550                 555                 560 


Leu Lys Asp Pro Glu Lys Thr Gln Glu Ala Leu Asp Ser Asp Gly Trp 
                565                 570                 575     


Leu His Thr Gly Asp Ile Gly Arg Trp Leu Pro Asn Gly Thr Leu Lys 
            580                 585                 590         


Ile Ile Asp Arg Lys Lys Asn Ile Phe Lys Leu Ala Gln Gly Glu Tyr 
        595                 600                 605             


Ile Ala Pro Glu Lys Ile Glu Asn Ile Tyr Asn Arg Ser Gln Pro Val 
    610                 615                 620                 


Leu Gln Ile Phe Val His Gly Glu Ser Leu Arg Ser Ser Leu Val Gly 
625                 630                 635                 640 


Val Val Val Pro Asp Thr Asp Val Leu Pro Ser Phe Ala Ala Lys Leu 
                645                 650                 655     


Gly Val Lys Gly Ser Phe Glu Glu Leu Cys Gln Asn Gln Val Val Arg 
            660                 665                 670         


Glu Ala Ile Leu Glu Asp Leu Gln Lys Ile Gly Lys Glu Ser Gly Leu 
        675                 680                 685             


Lys Thr Phe Glu Gln Val Lys Ala Ile Phe Leu His Pro Glu Pro Phe 
    690                 695                 700                 


Ser Ile Glu Asn Gly Leu Leu Thr Pro Thr Leu Lys Ala Lys Arg Gly 
705                 710                 715                 720 


Glu Leu Ser Lys Tyr Phe Arg Thr Gln Ile Asp Ser Leu Tyr Glu His 
                725                 730                 735     


Ile Gln Asp 
            


<210>  4189
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  4189

Met Phe Val Ala Ser Glu Arg Lys Met Arg Ala His Gln Val Leu Thr 
1               5                   10                  15      


Phe Leu Leu Leu Phe Val Ile Thr Ser Val Ala Ser Glu Asn Ala Ser 
            20                  25                  30          


Thr Ser Arg Gly Cys Gly Leu Asp Leu Leu Pro Gln Tyr Val Ser Leu 
        35                  40                  45              


Cys Asp Leu Asp Ala Ile Trp Gly Ile Val Val Glu Ala Val Ala Gly 
    50                  55                  60                  


Ala Gly Ala Leu Ile Thr Leu Leu Leu Met Leu Ile Leu Leu Val Arg 
65                  70                  75                  80  


Leu Pro Phe Ile Lys Glu Lys Glu Lys Lys Ser Pro Val Gly Leu His 
                85                  90                  95      


Phe Leu Phe Leu Leu Gly Thr Leu Gly Leu Phe Gly Leu Thr Phe Ala 
            100                 105                 110         


Phe Ile Ile Gln Glu Asp Glu Thr Ile Cys Ser Val Arg Arg Phe Leu 
        115                 120                 125             


Trp Gly Val Leu Phe Ala Leu Cys Phe Ser Cys Leu Leu Ser Gln Ala 
    130                 135                 140                 


Trp Arg Val Arg Arg Leu Val Arg His Gly Thr Gly Pro Ala Gly Trp 
145                 150                 155                 160 


Gln Leu Val Gly Leu Ala Leu Cys Leu Met Leu Val Gln Val Ile Ile 
                165                 170                 175     


Ala Val Glu Trp Leu Val Leu Thr Val Leu Arg Asp Thr Arg Pro Ala 
            180                 185                 190         


Cys Ala Tyr Glu Pro Met Asp Phe Val Met Ala Leu Ile Tyr Asp Met 
        195                 200                 205             


Val Leu Leu Val Val Thr Leu Gly Leu Ala Leu Phe Thr Leu Cys Gly 
    210                 215                 220                 


Lys Phe Lys Arg Trp Lys Leu Asn Gly Ala Phe Leu Leu Ile Thr Ala 
225                 230                 235                 240 


Phe Leu Ser Val Leu Ile Trp Val Ala Trp Met Thr Met Tyr Leu Phe 
                245                 250                 255     


Gly Asn Val Lys Leu Gln Gln Gly Asp Ala Trp Asn Asp Pro Thr Leu 
            260                 265                 270         


Ala Ile Thr Leu Ala Ala Ser Gly Trp Val Phe Val Ile Phe His Ala 
        275                 280                 285             


Ile Pro Glu Ile His Cys Thr Leu Leu Pro Ala Leu Gln Glu Asn Thr 
    290                 295                 300                 


Pro Asn Tyr Phe Asp Thr Ser Gln Pro Arg Met Arg Glu Thr Ala Phe 
305                 310                 315                 320 


Glu Glu Asp Val Gln Leu Pro Arg Ala Tyr Met Glu Asn Lys Ala Phe 
                325                 330                 335     


Ser Met Asp Glu His Asn Ala Ala Leu Arg Thr Ala Gly Phe Pro Asn 
            340                 345                 350         


Gly Ser Leu Gly Lys Arg Pro Ser Gly Ser Leu Gly Lys Arg Pro Ser 
        355                 360                 365             


Ala Pro Phe Arg Ser Asn Val Tyr Gln Pro Thr Glu Met Ala Val Val 
    370                 375                 380                 


Leu Asn Gly Gly Thr Ile Pro Thr Ala Pro Pro Ser His Thr Gly Arg 
385                 390                 395                 400 


His Leu Trp 
            


<210>  4190
<211>  606
<212>  PRT
<213>  Homo sapiens

<400>  4190

Met Lys Val Arg Ser Ala Gly Gly Asp Gly Asp Ala Leu Cys Val Thr 
1               5                   10                  15      


Glu Glu Asp Leu Ala Gly Asp Asp Glu Asp Met Pro Thr Phe Pro Cys 
            20                  25                  30          


Thr Gln Lys Gly Arg Pro Gly Pro Arg Cys Ser Arg Cys Gln Lys Asn 
        35                  40                  45              


Leu Ser Leu His Thr Ser Val Arg Ile Leu Tyr Leu Phe Leu Ala Leu 
    50                  55                  60                  


Leu Leu Val Ala Val Ala Val Leu Ala Ser Leu Val Phe Arg Lys Val 
65                  70                  75                  80  


Asp Ser Leu Ser Glu Asp Ile Ser Leu Thr Gln Ser Ile Tyr Asp Lys 
                85                  90                  95      


Lys Leu Val Leu Met Gln Lys Asn Leu Gln Gly Leu Asp Pro Lys Ala 
            100                 105                 110         


Leu Asn Asn Cys Ser Phe Cys His Glu Ala Gly Gln Leu Gly Pro Glu 
        115                 120                 125             


Ile Arg Lys Leu Gln Glu Glu Leu Glu Gly Ile Gln Lys Leu Leu Leu 
    130                 135                 140                 


Ala Gln Glu Val Gln Leu Asp Gln Thr Leu Gln Ala Gln Glu Val Leu 
145                 150                 155                 160 


Ser Thr Thr Ser Arg Gln Ile Ser Gln Glu Met Gly Ser Cys Ser Phe 
                165                 170                 175     


Ser Ile His Gln Val Asn Gln Ser Leu Gly Leu Phe Leu Ala Gln Val 
            180                 185                 190         


Arg Gly Trp Gln Ala Thr Thr Ala Gly Leu Asp Leu Ser Leu Lys Asp 
        195                 200                 205             


Leu Thr Gln Glu Cys Tyr Asp Val Lys Ala Ala Val His Gln Ile Asn 
    210                 215                 220                 


Phe Thr Val Gly Gln Thr Ser Glu Trp Ile His Gly Ile Gln Arg Lys 
225                 230                 235                 240 


Thr Asp Glu Glu Thr Leu Thr Leu Gln Lys Ile Val Thr Asp Trp Gln 
                245                 250                 255     


Asn Tyr Thr Arg Leu Phe Ser Gly Leu Arg Thr Thr Ser Thr Lys Thr 
            260                 265                 270         


Gly Glu Ala Val Lys Asn Ile Gln Ala Thr Leu Gly Ala Ser Ser Gln 
        275                 280                 285             


Arg Ile Ser Gln Asn Ser Glu Ser Met His Asp Leu Val Leu Gln Val 
    290                 295                 300                 


Met Gly Leu Gln Leu Gln Leu Asp Asn Ile Ser Ser Phe Leu Asp Asp 
305                 310                 315                 320 


His Glu Glu Asn Met His Asp Leu Gln Tyr His Thr His Tyr Ala Gln 
                325                 330                 335     


Asn Arg Thr Val Glu Arg Phe Glu Ser Leu Glu Gly Arg Met Ala Ser 
            340                 345                 350         


His Glu Ile Glu Ile Gly Thr Ile Phe Thr Asn Ile Asn Ala Thr Asp 
        355                 360                 365             


Asn His Val His Ser Met Leu Lys Tyr Leu Asp Asp Val Arg Leu Ser 
    370                 375                 380                 


Cys Thr Leu Gly Phe His Thr His Ala Glu Glu Leu Tyr Tyr Leu Asn 
385                 390                 395                 400 


Lys Ser Val Ser Ile Met Leu Gly Thr Thr Asp Leu Leu Arg Glu Arg 
                405                 410                 415     


Phe Ser Leu Leu Ser Ala Arg Leu Asp Leu Asn Val Arg Asn Leu Ser 
            420                 425                 430         


Met Ile Val Glu Glu Met Lys Ala Val Asp Thr Gln His Gly Glu Ile 
        435                 440                 445             


Leu Arg Asn Val Thr Ile Leu Arg Gly Ala Pro Gly Pro Pro Gly Pro 
    450                 455                 460                 


Arg Gly Phe Lys Gly Asp Met Gly Val Lys Gly Pro Val Gly Gly Arg 
465                 470                 475                 480 


Gly Pro Lys Gly Asp Pro Gly Ser Leu Gly Pro Leu Gly Pro Gln Gly 
                485                 490                 495     


Pro Gln Gly Gln Pro Gly Glu Ala Gly Pro Val Gly Glu Arg Gly Pro 
            500                 505                 510         


Val Gly Pro Arg Gly Phe Pro Gly Leu Lys Gly Ser Lys Gly Ser Phe 
        515                 520                 525             


Gly Thr Gly Gly Pro Arg Gly Gln Pro Gly Pro Lys Gly Asp Ile Gly 
    530                 535                 540                 


Pro Pro Gly Pro Glu Gly Pro Pro Gly Ser Pro Gly Pro Ser Gly Pro 
545                 550                 555                 560 


Gln Gly Lys Pro Gly Ile Ala Gly Lys Thr Gly Ser Pro Gly Gln Arg 
                565                 570                 575     


Gly Ala Met Gly Pro Lys Gly Glu Pro Gly Ile Gln Gly Pro Pro Gly 
            580                 585                 590         


Leu Pro Gly Pro Pro Gly Pro Pro Gly Ser Gln Ser Phe Tyr 
        595                 600                 605     


<210>  4191
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  4191

Met Glu Leu Leu Gln Val Thr Ile Leu Phe Leu Leu Pro Ser Ile Cys 
1               5                   10                  15      


Ser Ser Asn Ser Thr Gly Val Leu Glu Ala Ala Asn Asn Ser Leu Val 
            20                  25                  30          


Val Thr Thr Thr Lys Pro Ser Ile Thr Thr Pro Asn Thr Glu Ser Leu 
        35                  40                  45              


Gln Lys Asn Val Val Thr Pro Thr Thr Gly Thr Thr Pro Lys Gly Thr 
    50                  55                  60                  


Ile Thr Asn Glu Leu Leu Lys Met Ser Leu Met Ser Thr Ala Thr Phe 
65                  70                  75                  80  


Leu Thr Ser Lys Asp Glu Gly Leu Lys Ala Thr Thr Thr Asp Val Arg 
                85                  90                  95      


Lys Asn Asp Ser Ile Ile Ser Asn Val Thr Val Thr Ser Val Thr Leu 
            100                 105                 110         


Pro Asn Ala Val Ser Thr Leu Gln Ser Ser Lys Pro Lys Thr Glu Thr 
        115                 120                 125             


Gln Ser Ser Ile Lys Thr Thr Glu Ile Pro Gly Ser Val Leu Gln Pro 
    130                 135                 140                 


Asp Ala Ser Pro Ser Lys Thr Gly Thr Leu Thr Ser Ile Pro Val Thr 
145                 150                 155                 160 


Ile Pro Glu Asn Thr Ser Gln Ser Gln Val Ile Gly Thr Glu Gly Gly 
                165                 170                 175     


Lys Asn Ala Ser Thr Ser Ala Thr Ser Arg Ser Tyr Ser Ser Ile Ile 
            180                 185                 190         


Leu Pro Val Val Ile Ala Leu Ile Val Ile Thr Leu Ser Val Phe Val 
        195                 200                 205             


Leu Val Gly Leu Tyr Arg Met Cys Trp Lys Ala Asp Pro Gly Thr Pro 
    210                 215                 220                 


Glu Asn Gly Asn Asp Gln Pro Gln Ser Asp Lys Glu Ser Val Lys Leu 
225                 230                 235                 240 


Leu Thr Val Lys Thr Ile Ser His Glu Ser Gly Glu His Ser Ala Gln 
                245                 250                 255     


Gly Lys Thr Lys Asn 
            260     


<210>  4192
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  4192

Met Gly Ile Gln Thr Ser Pro Val Leu Leu Ala Ser Leu Gly Val Gly 
1               5                   10                  15      


Leu Val Thr Leu Leu Gly Leu Ala Val Gly Ser Tyr Leu Val Arg Arg 
            20                  25                  30          


Ser Arg Arg Pro Gln Val Thr Leu Leu Asp Pro Asn Glu Lys Tyr Leu 
        35                  40                  45              


Leu Arg Leu Leu Asp Lys Thr Thr Val Ser His Asn Thr Lys Arg Phe 
    50                  55                  60                  


Arg Phe Ala Leu Pro Thr Ala His His Thr Leu Gly Leu Pro Val Gly 
65                  70                  75                  80  


Lys His Ile Tyr Leu Ser Thr Arg Ile Asp Gly Ser Leu Val Ile Arg 
                85                  90                  95      


Pro Tyr Thr Pro Val Thr Ser Asp Glu Asp Gln Gly Tyr Val Asp Leu 
            100                 105                 110         


Val Ile Lys Val Tyr Leu Lys Gly Val His Pro Lys Phe Pro Glu Gly 
        115                 120                 125             


Gly Lys Met Ser Gln Tyr Leu Asp Ser Leu Lys Val Gly Asp Val Val 
    130                 135                 140                 


Glu Phe Arg Gly Pro Ser Gly Leu Leu Thr Tyr Thr Gly Lys Gly His 
145                 150                 155                 160 


Phe Asn Ile Gln Pro Asn Lys Lys Ser Pro Pro Glu Pro Arg Val Ala 
                165                 170                 175     


Lys Lys Leu Gly Met Ile Ala Gly Gly Thr Gly Ile Thr Pro Met Leu 
            180                 185                 190         


Gln Leu Ile Arg Ala Ile Leu Lys Val Pro Glu Asp Pro Thr Gln Cys 
        195                 200                 205             


Phe Leu Leu Phe Ala Asn Gln Thr Glu Lys Asp Ile Ile Leu Arg Glu 
    210                 215                 220                 


Asp Leu Glu Glu Leu Gln Ala Arg Tyr Pro Asn Arg Phe Lys Leu Trp 
225                 230                 235                 240 


Phe Thr Leu Asp His Pro Pro Lys Asp Trp Ala Tyr Ser Lys Gly Phe 
                245                 250                 255     


Val Thr Ala Asp Met Ile Arg Glu His Leu Pro Ala Pro Gly Asp Asp 
            260                 265                 270         


Val Leu Val Leu Leu Cys Gly Pro Pro Pro Met Val Gln Leu Ala Cys 
        275                 280                 285             


His Pro Asn Leu Asp Lys Leu Gly Tyr Ser Gln Lys Met Arg Phe Thr 
    290                 295                 300                 


Tyr 
305 


<210>  4193
<211>  1241
<212>  PRT
<213>  Homo sapiens

<400>  4193

Met Ile Met Phe Pro Leu Phe Gly Lys Ile Ser Leu Gly Ile Leu Ile 
1               5                   10                  15      


Phe Val Leu Ile Glu Gly Asp Phe Pro Ser Leu Thr Ala Gln Thr Tyr 
            20                  25                  30          


Leu Ser Ile Glu Glu Ile Gln Glu Pro Lys Ser Ala Val Ser Phe Leu 
        35                  40                  45              


Leu Pro Glu Glu Ser Thr Asp Leu Ser Leu Ala Thr Lys Lys Lys Gln 
    50                  55                  60                  


Pro Leu Asp Arg Arg Glu Thr Glu Arg Gln Trp Leu Ile Arg Arg Arg 
65                  70                  75                  80  


Arg Ser Ile Leu Phe Pro Asn Gly Val Lys Ile Cys Pro Asp Glu Ser 
                85                  90                  95      


Val Ala Glu Ala Val Ala Asn His Val Lys Tyr Phe Lys Val Arg Val 
            100                 105                 110         


Cys Gln Glu Ala Val Trp Glu Ala Phe Arg Thr Phe Trp Asp Arg Leu 
        115                 120                 125             


Pro Gly Arg Glu Glu Tyr His Tyr Trp Met Asn Leu Cys Glu Asp Gly 
    130                 135                 140                 


Val Thr Ser Ile Phe Glu Met Gly Thr Asn Phe Ser Glu Ser Val Glu 
145                 150                 155                 160 


His Arg Ser Leu Ile Met Lys Lys Leu Thr Tyr Ala Lys Glu Thr Val 
                165                 170                 175     


Ser Ser Ser Glu Leu Ser Ser Pro Val Pro Val Gly Asp Thr Ser Thr 
            180                 185                 190         


Leu Gly Asp Thr Thr Leu Ser Val Pro His Pro Glu Val Asp Ala Tyr 
        195                 200                 205             


Glu Gly Ala Ser Glu Ser Ser Leu Glu Arg Pro Glu Glu Ser Ile Ser 
    210                 215                 220                 


Asn Glu Ile Glu Asn Val Ile Glu Glu Ala Thr Lys Pro Ala Gly Glu 
225                 230                 235                 240 


Gln Ile Ala Glu Phe Ser Ile His Leu Leu Gly Lys Gln Tyr Arg Glu 
                245                 250                 255     


Glu Leu Gln Asp Ser Ser Ser Phe His His Gln His Leu Glu Glu Glu 
            260                 265                 270         


Phe Ile Ser Glu Val Glu Asn Ala Phe Thr Gly Leu Pro Gly Tyr Lys 
        275                 280                 285             


Glu Ile Arg Val Leu Glu Phe Arg Ser Pro Lys Glu Asn Asp Ser Gly 
    290                 295                 300                 


Val Asp Val Tyr Tyr Ala Val Thr Phe Asn Gly Glu Ala Ile Ser Asn 
305                 310                 315                 320 


Thr Thr Trp Asp Leu Ile Ser Leu His Ser Asn Lys Val Glu Asn His 
                325                 330                 335     


Gly Leu Val Glu Leu Asp Asp Lys Pro Thr Val Val Tyr Thr Ile Ser 
            340                 345                 350         


Asn Phe Arg Asp Tyr Ile Ala Glu Thr Leu Gln Gln Asn Phe Leu Leu 
        355                 360                 365             


Gly Asn Ser Ser Leu Asn Pro Asp Pro Asp Ser Leu Gln Leu Ile Asn 
    370                 375                 380                 


Val Arg Gly Val Leu Arg His Gln Thr Glu Asp Leu Val Trp Asn Thr 
385                 390                 395                 400 


Gln Ser Ser Ser Leu Gln Ala Thr Pro Ser Ser Ile Leu Asp Asn Thr 
                405                 410                 415     


Phe Gln Ala Ala Trp Pro Ser Ala Asp Glu Ser Ile Thr Ser Ser Ile 
            420                 425                 430         


Pro Pro Leu Asp Phe Ser Ser Gly Pro Pro Ser Ala Thr Gly Arg Glu 
        435                 440                 445             


Leu Trp Ser Glu Ser Pro Leu Gly Asp Leu Val Ser Thr His Lys Leu 
    450                 455                 460                 


Ala Phe Pro Ser Lys Met Gly Leu Ser Ser Ser Pro Glu Val Leu Glu 
465                 470                 475                 480 


Val Ser Ser Leu Thr Leu His Ser Val Thr Pro Ala Val Leu Gln Thr 
                485                 490                 495     


Gly Leu Pro Val Ala Ser Glu Glu Arg Thr Ser Gly Ser His Leu Val 
            500                 505                 510         


Glu Asp Gly Leu Ala Asn Val Glu Glu Ser Glu Asp Phe Leu Ser Ile 
        515                 520                 525             


Asp Ser Leu Pro Ser Ser Ser Phe Thr Gln Pro Val Pro Lys Glu Thr 
    530                 535                 540                 


Ile Pro Ser Met Glu Asp Ser Asp Val Ser Leu Thr Ser Ser Pro Tyr 
545                 550                 555                 560 


Leu Thr Ser Ser Ile Pro Phe Gly Leu Asp Ser Leu Thr Ser Lys Val 
                565                 570                 575     


Lys Asp Gln Leu Lys Val Ser Pro Phe Leu Pro Asp Ala Ser Met Glu 
            580                 585                 590         


Lys Glu Leu Ile Phe Asp Gly Gly Leu Gly Ser Gly Ser Gly Gln Lys 
        595                 600                 605             


Val Asp Leu Ile Thr Trp Pro Trp Ser Glu Thr Ser Ser Glu Lys Ser 
    610                 615                 620                 


Ala Glu Pro Leu Ser Lys Pro Trp Leu Glu Asp Asp Asp Ser Leu Leu 
625                 630                 635                 640 


Pro Ala Glu Ile Glu Asp Lys Lys Leu Val Leu Val Asp Lys Met Asp 
                645                 650                 655     


Ser Thr Asp Gln Ile Ser Lys His Ser Lys Tyr Glu His Asp Asp Arg 
            660                 665                 670         


Ser Thr His Phe Pro Glu Glu Glu Pro Leu Ser Gly Pro Ala Val Pro 
        675                 680                 685             


Ile Phe Ala Asp Thr Ala Ala Glu Ser Ala Ser Leu Thr Leu Pro Lys 
    690                 695                 700                 


His Ile Ser Glu Val Pro Gly Val Asp Asp Tyr Ser Val Thr Lys Ala 
705                 710                 715                 720 


Pro Leu Ile Leu Thr Ser Val Ala Ile Ser Ala Ser Thr Asp Lys Ser 
                725                 730                 735     


Asp Gln Ala Asp Ala Ile Leu Arg Glu Asp Met Glu Gln Ile Thr Glu 
            740                 745                 750         


Ser Ser Asn Tyr Glu Trp Phe Asp Ser Glu Val Ser Met Val Lys Pro 
        755                 760                 765             


Asp Met Gln Thr Leu Trp Thr Ile Leu Pro Glu Ser Glu Arg Val Trp 
    770                 775                 780                 


Thr Arg Thr Ser Ser Leu Glu Lys Leu Ser Arg Asp Ile Leu Ala Ser 
785                 790                 795                 800 


Thr Pro Gln Ser Ala Asp Arg Leu Trp Leu Ser Val Thr Gln Ser Thr 
                805                 810                 815     


Lys Leu Pro Pro Thr Thr Ile Ser Thr Leu Leu Glu Asp Glu Val Ile 
            820                 825                 830         


Met Gly Val Gln Asp Ile Ser Leu Glu Leu Asp Arg Ile Gly Thr Asp 
        835                 840                 845             


Tyr Tyr Gln Pro Glu Gln Val Gln Glu Gln Asn Gly Lys Val Gly Ser 
    850                 855                 860                 


Tyr Val Glu Met Ser Thr Ser Val His Ser Thr Glu Met Val Ser Val 
865                 870                 875                 880 


Ala Trp Pro Thr Glu Gly Gly Asp Asp Leu Ser Tyr Thr Gln Thr Ser 
                885                 890                 895     


Gly Ala Leu Val Val Phe Phe Ser Leu Arg Val Thr Asn Met Met Phe 
            900                 905                 910         


Ser Glu Asp Leu Phe Asn Lys Asn Ser Leu Glu Tyr Lys Ala Leu Glu 
        915                 920                 925             


Gln Arg Phe Leu Glu Leu Leu Val Pro Tyr Leu Gln Ser Asn Leu Thr 
    930                 935                 940                 


Gly Phe Gln Asn Leu Glu Ile Leu Asn Phe Arg Asn Gly Ser Ile Val 
945                 950                 955                 960 


Val Asn Ser Arg Met Lys Phe Ala Asn Ser Val Pro Pro Asn Val Asn 
                965                 970                 975     


Asn Ala Val Tyr Met Ile Leu Glu Asp Phe Cys Thr Thr Ala Tyr Asn 
            980                 985                 990         


Thr Met Asn Leu Ala Ile Asp Lys  Tyr Ser Leu Asp Val  Glu Ser Gly 
        995                 1000                 1005             


Asp Glu  Ala Asn Pro Cys Lys  Phe Gln Ala Cys Asn  Glu Phe Ser 
    1010                 1015                 1020             


Glu Cys  Leu Val Asn Pro Trp  Ser Gly Glu Ala Lys  Cys Arg Cys 
    1025                 1030                 1035             


Phe Pro  Gly Tyr Leu Ser Val  Glu Glu Arg Pro Cys  Gln Ser Leu 
    1040                 1045                 1050             


Cys Asp  Leu Gln Pro Asp Phe  Cys Leu Asn Asp Gly  Lys Cys Asp 
    1055                 1060                 1065             


Ile Met  Pro Gly His Gly Ala  Ile Cys Arg Cys Arg  Val Gly Glu 
    1070                 1075                 1080             


Asn Trp  Trp Tyr Arg Gly Lys  His Cys Glu Glu Phe  Val Ser Glu 
    1085                 1090                 1095             


Pro Val  Ile Ile Gly Ile Thr  Ile Ala Ser Val Val  Gly Leu Leu 
    1100                 1105                 1110             


Val Ile  Phe Ser Ala Ile Ile  Tyr Phe Phe Ile Arg  Thr Leu Gln 
    1115                 1120                 1125             


Ala His  His Asp Arg Ser Glu  Arg Glu Ser Pro Phe  Ser Gly Ser 
    1130                 1135                 1140             


Ser Arg  Gln Pro Asp Ser Leu  Ser Ser Ile Glu Asn  Ala Val Lys 
    1145                 1150                 1155             


Tyr Asn  Pro Val Tyr Glu Ser  His Arg Ala Gly Cys  Glu Lys Tyr 
    1160                 1165                 1170             


Glu Gly  Pro Tyr Pro Gln His  Pro Phe Tyr Ser Ser  Ala Ser Gly 
    1175                 1180                 1185             


Asp Val  Ile Gly Gly Leu Ser  Arg Glu Glu Ile Arg  Gln Met Tyr 
    1190                 1195                 1200             


Glu Ser  Ser Glu Leu Ser Arg  Glu Glu Ile Gln Glu  Arg Met Arg 
    1205                 1210                 1215             


Val Leu  Glu Leu Tyr Ala Asn  Asp Pro Glu Phe Ala  Ala Phe Val 
    1220                 1225                 1230             


Arg Glu  Gln Gln Val Glu Glu  Val 
    1235                 1240     


<210>  4194
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  4194

Met Ala Glu Leu Gln Glu Val Gln Ile Thr Glu Glu Lys Pro Leu Leu 
1               5                   10                  15      


Pro Gly Gln Thr Pro Glu Ala Ala Lys Thr His Ser Val Glu Thr Pro 
            20                  25                  30          


Tyr Gly Ser Val Thr Phe Thr Val Tyr Gly Thr Pro Lys Pro Lys Arg 
        35                  40                  45              


Pro Ala Ile Leu Thr Tyr His Asp Val Gly Leu Asn Tyr Lys Ser Cys 
    50                  55                  60                  


Phe Gln Pro Leu Phe Gln Phe Glu Asp Met Gln Glu Ile Ile Gln Asn 
65                  70                  75                  80  


Phe Val Arg Val His Val Asp Ala Pro Gly Met Glu Glu Gly Ala Pro 
                85                  90                  95      


Val Phe Pro Leu Gly Tyr Gln Tyr Pro Ser Leu Asp Gln Leu Ala Asp 
            100                 105                 110         


Met Ile Pro Cys Val Leu Gln Tyr Leu Asn Phe Ser Thr Ile Ile Gly 
        115                 120                 125             


Val Gly Val Gly Ala Gly Ala Tyr Ile Leu Ala Arg Tyr Ala Leu Asn 
    130                 135                 140                 


His Pro Asp Thr Val Glu Gly Leu Val Leu Ile Asn Ile Asp Pro Asn 
145                 150                 155                 160 


Ala Lys Gly Trp Met Asp Trp Ala Ala His Lys Leu Thr Gly Leu Thr 
                165                 170                 175     


Ser Ser Ile Pro Glu Met Ile Leu Gly His Leu Phe Ser Gln Glu Glu 
            180                 185                 190         


Leu Ser Gly Asn Ser Glu Leu Ile Gln Lys Tyr Arg Asn Ile Ile Thr 
        195                 200                 205             


His Ala Pro Asn Leu Asp Asn Ile Glu Leu Tyr Trp Asn Ser Tyr Asn 
    210                 215                 220                 


Asn Arg Arg Asp Leu Asn Phe Glu Arg Gly Gly Asp Ile Thr Leu Arg 
225                 230                 235                 240 


Cys Pro Val Met Leu Val Val Gly Asp Gln Ala Pro His Glu Asp Ala 
                245                 250                 255     


Val Val Glu Cys Asn Ser Lys Leu Asp Pro Thr Gln Thr Ser Phe Leu 
            260                 265                 270         


Lys Met Ala Asp Ser Gly Gly Gln Pro Gln Leu Thr Gln Pro Gly Lys 
        275                 280                 285             


Leu Thr Glu Ala Phe Lys Tyr Phe Leu Gln Gly Met Gly Tyr Met Ala 
    290                 295                 300                 


Ser Ser Cys Met Thr Arg Leu Ser Arg Ser Arg Thr Ala Ser Leu Thr 
305                 310                 315                 320 


Ser Ala Ala Ser Val Asp Gly Asn Arg Ser Arg Ser Arg Thr Leu Ser 
                325                 330                 335     


Gln Ser Ser Glu Ser Gly Thr Leu Ser Ser Gly Pro Pro Gly His Thr 
            340                 345                 350         


Met Glu Val Ser Cys 
        355         


<210>  4195
<211>  413
<212>  PRT
<213>  Homo sapiens

<400>  4195

Met Ala Glu Gly Pro Glu Glu Ala Arg Gly His Pro Pro Gly Gln Asp 
1               5                   10                  15      


Asp Gly Gly Gly Asp His Glu Pro Val Pro Ser Leu Arg Gly Pro Pro 
            20                  25                  30          


Thr Thr Ala Val Pro Cys Pro Arg Asp Asp Pro Gln Ala Glu Pro Gln 
        35                  40                  45              


Ala Pro Gly Arg Pro Thr Ala Pro Gly Leu Ala Ala Ala Ala Ala Ala 
    50                  55                  60                  


Asp Lys Leu Glu Pro Pro Arg Glu Leu Arg Lys Arg Gly Glu Ala Ala 
65                  70                  75                  80  


Ser Gly Ser Gly Ala Glu Leu Gln Glu Gln Ala Gly Cys Glu Ala Pro 
                85                  90                  95      


Glu Ala Ala Ala Pro Arg Glu Arg Pro Ala Arg Leu Ser Ala Arg Glu 
            100                 105                 110         


Tyr Ser Arg Gln Val His Glu Trp Leu Trp Gln Ser Tyr Cys Gly Tyr 
        115                 120                 125             


Leu Thr Trp His Ser Gly Leu Ala Ala Phe Pro Ala Tyr Cys Ser Pro 
    130                 135                 140                 


Gln Pro Ser Pro Gln Ser Phe Pro Ser Gly Gly Ala Ala Val Pro Gln 
145                 150                 155                 160 


Ala Ala Ala Pro Pro Pro Pro Gln Leu Gly Tyr Tyr Asn Pro Phe Tyr 
                165                 170                 175     


Phe Leu Ser Pro Gly Ala Ala Gly Pro Asp Pro Arg Thr Ala Ala Gly 
            180                 185                 190         


Ile Ser Thr Pro Ala Pro Val Ala Gly Leu Gly Pro Arg Ala Pro His 
        195                 200                 205             


Val Gln Ala Ser Val Arg Ala Thr Pro Val Thr Arg Val Gly Ser Ala 
    210                 215                 220                 


Ala Pro Ser Arg Ser Pro Ser Glu Thr Gly Arg Gln Ala Gly Arg Glu 
225                 230                 235                 240 


Tyr Val Ile Pro Ser Leu Ala His Arg Phe Met Ala Glu Met Val Asp 
                245                 250                 255     


Phe Phe Ile Leu Phe Phe Ile Lys Ala Thr Ile Val Leu Ser Ile Met 
            260                 265                 270         


His Leu Ser Gly Ile Lys Asp Ile Ser Lys Phe Ala Met His Tyr Ile 
        275                 280                 285             


Ile Glu Glu Ile Asp Glu Asp Thr Ser Met Glu Asp Leu Gln Lys Met 
    290                 295                 300                 


Met Val Val Ala Leu Ile Tyr Arg Leu Leu Val Cys Phe Tyr Glu Ile 
305                 310                 315                 320 


Ile Cys Ile Trp Gly Ala Gly Gly Ala Thr Pro Gly Lys Phe Leu Leu 
                325                 330                 335     


Gly Leu Arg Val Val Thr Cys Asp Thr Ser Val Leu Ile Ala Pro Ser 
            340                 345                 350         


Arg Val Leu Val Ile Pro Ser Ser Asn Val Ser Ile Thr Thr Ser Thr 
        355                 360                 365             


Ile Arg Ala Leu Ile Lys Asn Phe Ser Ile Ala Ser Phe Phe Pro Ala 
    370                 375                 380                 


Phe Ile Thr Leu Leu Phe Phe Gln His Asn Arg Thr Ala Tyr Asp Ile 
385                 390                 395                 400 


Val Ala Gly Thr Ile Val Val Lys Arg Asn Gly Val Arg 
                405                 410             


<210>  4196
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  4196

Met Ser Ile Val Thr Val Gln Leu Gly Gln Cys Gly Asn Gln Ile Gly 
1               5                   10                  15      


Phe Glu Val Phe Asp Ala Leu Leu Ser Asp Ser His Ser Ser Gln Gly 
            20                  25                  30          


Leu Cys Ser Met Arg Glu Asn Glu Ala Tyr Gln Ala Ser Cys Lys Glu 
        35                  40                  45              


Arg Phe Phe Ser Glu Glu Glu Asn Gly Val Pro Ile Ala Arg Ala Val 
    50                  55                  60                  


Leu Val Asp Met Glu Pro Lys Val Ile Asn Gln Met Leu Ser Lys Ala 
65                  70                  75                  80  


Ala Gln Ser Gly Gln Trp Lys Tyr Gly Gln His Ala Cys Phe Cys Gln 
                85                  90                  95      


Lys Gln Gly Ser Gly Asn Asn Trp Ala Tyr Gly Tyr Ser Val His Gly 
            100                 105                 110         


Pro Arg His Glu Glu Ser Ile Met Asn Ile Ile Arg Lys Glu Val Glu 
        115                 120                 125             


Lys Cys Asp Ser Phe Ser Gly Phe Phe Ile Ile Met Ser Met Ala Gly 
    130                 135                 140                 


Gly Thr Gly Ser Gly Leu Gly Ala Phe Val Thr Gln Asn Leu Glu Asp 
145                 150                 155                 160 


Gln Tyr Ser Asn Ser Leu Lys Met Asn Gln Ile Ile Trp Pro Tyr Gly 
                165                 170                 175     


Thr Gly Glu Val Ile Val Gln Asn Tyr Asn Ser Ile Leu Thr Leu Ser 
            180                 185                 190         


His Leu Tyr Arg Ser Ser Asp Ala Leu Leu Leu His Glu Asn Asp Ala 
        195                 200                 205             


Ile His Lys Ile Cys Ala Lys Leu Met Asn Ile Lys Gln Ile Ser Phe 
    210                 215                 220                 


Ser Asp Ile Asn Gln Val Leu Ala His Gln Leu Gly Ser Val Phe Gln 
225                 230                 235                 240 


Pro Thr Tyr Ser Ala Glu Ser Ser Phe His Tyr Arg Arg Asn Pro Leu 
                245                 250                 255     


Gly Asp Leu Met Glu His Leu Val Pro His Pro Glu Phe Lys Met Leu 
            260                 265                 270         


Ser Val Arg Asn Ile Pro His Met Ser Glu Asn Ser Leu Ala Tyr Thr 
        275                 280                 285             


Thr Phe Thr Trp Ala Gly Leu Leu Lys His Leu Arg Gln Met Leu Ile 
    290                 295                 300                 


Ser Asn Ala Lys Met Glu Glu Gly Ile Asp Arg His Val Trp Pro Pro 
305                 310                 315                 320 


Leu Ser Gly Leu Pro Pro Leu Ser Lys Met Ser Leu Asn Lys Asp Leu 
                325                 330                 335     


His Phe Asn Thr Ser Ile Ala Asn Leu Val Ile Leu Arg Gly Lys Asp 
            340                 345                 350         


Val Gln Ser Ala Asp Val Glu Gly Phe Lys Asp Pro Ala Leu Tyr Thr 
        355                 360                 365             


Ser Trp Leu Lys Pro Val Asn Ala Phe Asn Val Trp Lys Thr Gln Arg 
    370                 375                 380                 


Ala Phe Ser Lys Tyr Glu Lys Ser Ala Val Leu Val Ser Asn Ser Gln 
385                 390                 395                 400 


Phe Leu Val Lys Pro Leu Asp Met Ile Val Gly Lys Ala Trp Asn Met 
                405                 410                 415     


Phe Ala Ser Lys Ala Tyr Ile His Gln Tyr Thr Lys Phe Gly Ile Glu 
            420                 425                 430         


Glu Glu Asp Phe Leu Asp Ser Phe Thr Ser Leu Glu Gln Val Val Ala 
        435                 440                 445             


Ser Tyr Cys Asn Leu 
    450             


<210>  4197
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  4197

Met Arg Leu Leu Leu Leu Leu Leu Val Ala Ala Ser Ala Met Val Arg 
1               5                   10                  15      


Ser Glu Ala Ser Ala Asn Leu Gly Gly Val Pro Ser Lys Arg Leu Lys 
            20                  25                  30          


Met Gln Tyr Ala Thr Gly Pro Leu Leu Lys Phe Gln Ile Cys Val Ser 
        35                  40                  45              


Gly Tyr Arg Arg Val Phe Glu Glu Tyr Met Arg Val Ile Ser Gln Arg 
    50                  55                  60                  


Tyr Pro Asp Ile Arg Ile Glu Gly Glu Asn Tyr Leu Pro Gln Pro Ile 
65                  70                  75                  80  


Tyr Arg His Ile Ala Ser Phe Leu Ser Val Phe Lys Leu Val Leu Ile 
                85                  90                  95      


Gly Leu Ile Ile Val Gly Lys Asp Pro Phe Ala Phe Phe Gly Met Gln 
            100                 105                 110         


Ala Pro Ser Ile Trp Gln Trp Gly Gln Glu Asn Lys Val Tyr Ala Cys 
        115                 120                 125             


Met Met Val Phe Phe Leu Ser Asn Met Ile Glu Asn Gln Cys Met Ser 
    130                 135                 140                 


Thr Gly Ala Phe Glu Ile Thr Leu Asn Asp Val Pro Val Trp Ser Lys 
145                 150                 155                 160 


Leu Glu Ser Gly His Leu Pro Ser Met Gln Gln Leu Val Gln Ile Leu 
                165                 170                 175     


Asp Asn Glu Met Lys Leu Asn Val His Met Asp Ser Ile Pro His His 
            180                 185                 190         


Arg Ser 
        


<210>  4198
<211>  789
<212>  PRT
<213>  Homo sapiens

<400>  4198

Met Arg Thr Tyr His Tyr Ile Pro Leu Phe Ile Trp Thr Tyr Met Phe 
1               5                   10                  15      


His Thr Val Asp Thr Ile Leu Leu Gln Glu Lys Pro Asn Ser Tyr Leu 
            20                  25                  30          


Ser Ser Lys Lys Ile Ala Gly Leu Thr Lys Asp Asp Gly Lys Met Leu 
        35                  40                  45              


Arg Arg Thr Lys Arg Gly Trp Met Trp Asn Gln Phe Phe Leu Leu Glu 
    50                  55                  60                  


Glu Tyr Thr Gly Thr Asp Thr Gln Tyr Val Gly Lys Leu His Thr Asp 
65                  70                  75                  80  


Gln Asp Lys Gly Asp Gly Asn Leu Lys Tyr Ile Leu Thr Gly Asp Gly 
                85                  90                  95      


Ala Gly Ser Leu Phe Val Ile Asp Glu Asn Thr Gly Asp Ile His Ala 
            100                 105                 110         


Ala Lys Lys Leu Asp Arg Glu Glu Lys Ser Leu Tyr Ile Leu Arg Ala 
        115                 120                 125             


Lys Ala Ile Asp Arg Lys Thr Gly Arg Gln Val Glu Pro Glu Ser Glu 
    130                 135                 140                 


Phe Ile Ile Lys Ile His Asp Ile Asn Asp Asn Glu Pro Lys Phe Thr 
145                 150                 155                 160 


Lys Asp Leu Tyr Thr Ala Ser Val Pro Glu Met Ser Gly Val Gly Thr 
                165                 170                 175     


Ser Val Ile Gln Val Thr Ala Thr Asp Ala Asp Asp Ala Asn Tyr Gly 
            180                 185                 190         


Asn Ser Ala Lys Val Val Tyr Ser Ile Leu Gln Gly Gln Pro Tyr Phe 
        195                 200                 205             


Ser Val Asp Pro Glu Ser Gly Ile Ile Lys Thr Ala Leu Pro Asp Met 
    210                 215                 220                 


Ser Arg Glu Asn Arg Glu Gln Tyr Gln Val Val Ile Gln Ala Lys Asp 
225                 230                 235                 240 


Met Gly Gly Gln Met Gly Gly Leu Ser Gly Thr Thr Thr Val Asn Ile 
                245                 250                 255     


Thr Leu Thr Asp Val Asn Asn Asn Pro Pro Arg Phe Pro Gln Ser Thr 
            260                 265                 270         


Tyr Gln Phe Asn Ser Pro Glu Ser Val Pro Leu Gly Thr His Leu Gly 
        275                 280                 285             


Arg Ile Lys Ala Asn Asp Pro Asp Val Gly Glu Asn Ala Glu Met Glu 
    290                 295                 300                 


Tyr Ser Ile Ala Glu Gly Asp Gly Ala Asp Met Phe Asp Val Ile Thr 
305                 310                 315                 320 


Asp Lys Asp Thr Gln Glu Gly Ile Ile Thr Val Lys Gln Asn Leu Asp 
                325                 330                 335     


Phe Glu Asn Gln Met Leu Tyr Thr Leu Arg Val Asp Ala Ser Asn Thr 
            340                 345                 350         


His Pro Asp Pro Arg Phe Leu His Leu Gly Pro Phe Lys Asp Thr Ala 
        355                 360                 365             


Val Val Lys Ile Ser Val Glu Asp Ile Asp Glu Pro Pro Val Phe Thr 
    370                 375                 380                 


Lys Val Ser Tyr Leu Ile Glu Val Asp Glu Asp Val Lys Glu Gly Ser 
385                 390                 395                 400 


Ile Ile Gly Gln Val Thr Ala Tyr Asp Pro Asp Ala Arg Asn Asn Leu 
                405                 410                 415     


Ile Lys Tyr Ser Val Asp Arg His Thr Asp Met Asp Arg Ile Phe Gly 
            420                 425                 430         


Ile His Ser Glu Asn Gly Ser Ile Phe Thr Leu Lys Ala Leu Asp Arg 
        435                 440                 445             


Glu Ser Ser Pro Trp His Asn Ile Thr Val Thr Ala Thr Glu Ile Asn 
    450                 455                 460                 


Asn Pro Lys Gln Ser Ser His Ile Pro Val Phe Ile Arg Ile Leu Asp 
465                 470                 475                 480 


Ile Asn Asp His Ala Pro Glu Phe Ala Met Tyr Tyr Glu Thr Phe Val 
                485                 490                 495     


Cys Glu Asn Ala Lys Pro Gly Gln Leu Ile Gln Thr Val Ser Val Met 
            500                 505                 510         


Asp Lys Asp Asp Pro Pro Arg Gly His Lys Phe Phe Phe Glu Pro Val 
        515                 520                 525             


Pro Glu Phe Thr Leu Asn Pro Asn Phe Thr Ile Val Asp Asn Lys Asp 
    530                 535                 540                 


Asn Thr Ala Gly Ile Met Thr Arg Lys Asp Gly Tyr Ser Arg Asn Lys 
545                 550                 555                 560 


Met Ser Thr Tyr Leu Leu Pro Ile Leu Ile Phe Asp Asn Asp Tyr Pro 
                565                 570                 575     


Ile Gln Ser Ser Thr Gly Thr Leu Thr Ile Arg Val Cys Ala Cys Asp 
            580                 585                 590         


Asn Gln Gly Asn Met Gln Ser Cys Thr Ala Glu Ala Leu Ile Leu Ser 
        595                 600                 605             


Ala Gly Leu Ser Thr Gly Ala Leu Val Ala Ile Leu Leu Cys Val Leu 
    610                 615                 620                 


Ile Leu Leu Ile Leu Val Val Leu Phe Ala Ala Leu Lys Arg Gln Arg 
625                 630                 635                 640 


Lys Lys Glu Pro Leu Ile Ile Ser Lys Asp Asp Val Arg Asp Asn Ile 
                645                 650                 655     


Val Thr Tyr Asn Asp Glu Gly Gly Gly Glu Glu Asp Thr Gln Ala Phe 
            660                 665                 670         


Asp Ile Gly Thr Leu Arg Asn Pro Glu Ala Arg Glu Asp Ser Lys Leu 
        675                 680                 685             


Arg Arg Asp Val Met Pro Glu Thr Ile Phe Gln Ile Arg Arg Thr Val 
    690                 695                 700                 


Pro Leu Trp Glu Asn Ile Asp Val Gln Asp Phe Ile His Arg Arg Leu 
705                 710                 715                 720 


Lys Glu Asn Asp Ala Asp Pro Ser Ala Pro Pro Tyr Asp Ser Leu Ala 
                725                 730                 735     


Thr Tyr Ala Tyr Glu Gly Asn Asp Ser Ile Ala Asp Ser Leu Ser Ser 
            740                 745                 750         


Leu Glu Ser Leu Thr Ala Asp Cys Asn Gln Asp Tyr Asp Tyr Leu Ser 
        755                 760                 765             


Asp Trp Gly Pro Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Asp 
    770                 775                 780                 


Asp Ser Asp Arg Asp 
785                 


<210>  4199
<211>  2376
<212>  PRT
<213>  Homo sapiens

<400>  4199

Met Asn Leu Asp Ser Leu Ser Leu Ala Leu Ser Gln Ile Ser Tyr Leu 
1               5                   10                  15      


Val Asp Asn Leu Thr Lys Lys Asn Tyr Arg Ala Ser Gln Gln Glu Ile 
            20                  25                  30          


Gln His Ile Val Asn Arg His Gly Pro Glu Ala Asp Arg His Leu Leu 
        35                  40                  45              


Arg Cys Leu Phe Ser His Val Asp Phe Ser Gly Asp Gly Lys Ser Ser 
    50                  55                  60                  


Gly Lys Asp Phe His Gln Thr Gln Phe Leu Ile Gln Glu Cys Ala Leu 
65                  70                  75                  80  


Leu Ile Thr Lys Pro Asn Phe Ile Ser Thr Leu Ser Tyr Ala Ile Asp 
                85                  90                  95      


Asn Pro Leu His Tyr Gln Lys Ser Leu Lys Pro Ala Pro His Leu Phe 
            100                 105                 110         


Ala Gln Leu Ser Lys Val Leu Lys Leu Ser Lys Val Gln Glu Val Ile 
        115                 120                 125             


Phe Gly Leu Ala Leu Leu Asn Ser Ser Ser Ser Asp Leu Arg Gly Phe 
    130                 135                 140                 


Ala Ala Gln Phe Ile Lys Gln Lys Leu Pro Asp Leu Leu Arg Ser Tyr 
145                 150                 155                 160 


Ile Asp Ala Asp Val Ser Gly Asn Gln Glu Gly Gly Phe Gln Asp Ile 
                165                 170                 175     


Ala Ile Glu Val Leu His Leu Leu Leu Ser His Leu Leu Phe Gly Gln 
            180                 185                 190         


Lys Gly Ala Phe Gly Val Gly Gln Glu Gln Ile Asp Ala Phe Leu Lys 
        195                 200                 205             


Thr Leu Arg Arg Asp Phe Pro Gln Glu Arg Cys Pro Val Val Leu Ala 
    210                 215                 220                 


Pro Leu Leu Tyr Pro Glu Lys Arg Asp Ile Leu Met Asp Arg Ile Leu 
225                 230                 235                 240 


Pro Asp Ser Gly Gly Val Ala Lys Thr Met Met Glu Ser Ser Leu Ala 
                245                 250                 255     


Asp Phe Met Gln Glu Val Gly Tyr Gly Phe Cys Ala Ser Ile Glu Glu 
            260                 265                 270         


Cys Arg Asn Ile Ile Val Gln Phe Gly Val Arg Glu Val Thr Ala Ala 
        275                 280                 285             


Gln Val Ala Arg Val Leu Gly Met Met Ala Arg Thr His Ser Gly Leu 
    290                 295                 300                 


Thr Asp Gly Ile Pro Leu Gln Ser Ile Ser Ala Pro Gly Ser Gly Ile 
305                 310                 315                 320 


Trp Ser Asp Gly Lys Asp Lys Ser Asp Gly Ala Gln Ala His Thr Trp 
                325                 330                 335     


Asn Val Glu Val Leu Ile Asp Val Leu Lys Glu Leu Asn Pro Ser Leu 
            340                 345                 350         


Asn Phe Lys Glu Val Thr Tyr Glu Leu Asp His Pro Gly Phe Gln Ile 
        355                 360                 365             


Arg Asp Ser Lys Gly Leu His Asn Val Val Tyr Gly Ile Gln Arg Gly 
    370                 375                 380                 


Leu Gly Met Glu Val Phe Pro Val Asp Leu Ile Tyr Arg Pro Trp Lys 
385                 390                 395                 400 


His Ala Glu Gly Gln Leu Ser Phe Ile Gln His Ser Leu Ile Asn Pro 
                405                 410                 415     


Glu Ile Phe Cys Phe Ala Asp Tyr Pro Cys His Thr Val Ala Thr Asp 
            420                 425                 430         


Ile Leu Lys Ala Pro Pro Glu Asp Asp Asn Arg Glu Ile Ala Thr Trp 
        435                 440                 445             


Lys Ser Leu Asp Leu Ile Glu Ser Leu Leu Arg Leu Ala Glu Val Gly 
    450                 455                 460                 


Gln Tyr Glu Gln Val Lys Gln Leu Phe Ser Phe Pro Ile Lys His Cys 
465                 470                 475                 480 


Pro Asp Met Leu Val Leu Ala Leu Leu Gln Ile Asn Thr Ser Trp His 
                485                 490                 495     


Thr Leu Arg His Glu Leu Ile Ser Thr Leu Met Pro Ile Phe Leu Gly 
            500                 505                 510         


Asn His Pro Asn Ser Ala Ile Ile Leu His Tyr Ala Trp His Gly Gln 
        515                 520                 525             


Gly Gln Ser Pro Ser Ile Arg Gln Leu Ile Met His Ala Met Ala Glu 
    530                 535                 540                 


Trp Tyr Met Arg Gly Glu Gln Tyr Asp Gln Ala Lys Leu Ser Arg Ile 
545                 550                 555                 560 


Leu Asp Val Ala Gln Asp Leu Lys Ala Leu Ser Met Leu Leu Asn Gly 
                565                 570                 575     


Thr Pro Phe Ala Phe Val Ile Asp Leu Ala Ala Leu Ala Ser Arg Arg 
            580                 585                 590         


Glu Tyr Leu Lys Leu Asp Lys Trp Leu Thr Asp Lys Ile Arg Glu His 
        595                 600                 605             


Gly Glu Pro Phe Ile Gln Ala Cys Met Thr Phe Leu Lys Arg Arg Cys 
    610                 615                 620                 


Pro Ser Ile Leu Gly Gly Leu Ala Pro Glu Lys Asp Gln Pro Lys Ser 
625                 630                 635                 640 


Ala Gln Leu Pro Pro Glu Thr Leu Ala Thr Met Leu Ala Cys Leu Gln 
                645                 650                 655     


Ala Cys Ala Gly Ser Val Ser Gln Glu Leu Ser Glu Thr Ile Leu Thr 
            660                 665                 670         


Met Val Ala Asn Cys Ser Asn Val Met Asn Lys Ala Arg Gln Pro Pro 
        675                 680                 685             


Pro Gly Val Met Pro Lys Gly Arg Pro Pro Ser Ala Ser Ser Leu Asp 
    690                 695                 700                 


Ala Ile Ser Pro Val Gln Ile Asp Pro Leu Ala Gly Met Thr Ser Leu 
705                 710                 715                 720 


Ser Ile Gly Gly Ser Ala Ala Pro His Thr Gln Ser Met Gln Gly Phe 
                725                 730                 735     


Pro Pro Asn Leu Gly Ser Ala Phe Ser Thr Pro Gln Ser Pro Ala Lys 
            740                 745                 750         


Ala Phe Pro Pro Leu Ser Thr Pro Asn Gln Thr Thr Ala Phe Ser Gly 
        755                 760                 765             


Ile Gly Gly Leu Ser Ser Gln Leu Pro Val Gly Gly Leu Gly Thr Gly 
    770                 775                 780                 


Ser Leu Thr Gly Ile Gly Thr Gly Ala Leu Gly Leu Pro Ala Val Asn 
785                 790                 795                 800 


Asn Asp Pro Phe Val Gln Arg Lys Leu Gly Thr Ser Gly Leu Asn Gln 
                805                 810                 815     


Pro Thr Phe Gln Gln Ser Lys Met Lys Pro Ser Asp Leu Ser Gln Val 
            820                 825                 830         


Trp Pro Glu Ala Asn Gln His Phe Ser Lys Glu Ile Asp Asp Glu Ala 
        835                 840                 845             


Asn Ser Tyr Phe Gln Arg Ile Tyr Asn His Pro Pro His Pro Thr Met 
    850                 855                 860                 


Ser Val Asp Glu Val Leu Glu Met Leu Gln Arg Phe Lys Asp Ser Thr 
865                 870                 875                 880 


Ile Lys Arg Glu Arg Glu Val Phe Asn Cys Met Leu Arg Asn Leu Phe 
                885                 890                 895     


Glu Glu Tyr Arg Phe Phe Pro Gln Tyr Pro Asp Lys Glu Leu His Ile 
            900                 905                 910         


Thr Ala Cys Leu Phe Gly Gly Ile Ile Glu Lys Gly Leu Val Thr Tyr 
        915                 920                 925             


Met Ala Leu Gly Leu Ala Leu Arg Tyr Val Leu Glu Ala Leu Arg Lys 
    930                 935                 940                 


Pro Phe Gly Ser Lys Met Tyr Tyr Phe Gly Ile Ala Ala Leu Asp Arg 
945                 950                 955                 960 


Phe Lys Asn Arg Leu Lys Asp Tyr Pro Gln Tyr Cys Gln His Leu Ala 
                965                 970                 975     


Ser Ile Ser His Phe Met Gln Phe Pro His His Leu Gln Glu Tyr Ile 
            980                 985                 990         


Glu Tyr Gly Gln Gln Ser Arg Asp  Pro Pro Val Lys Met  Gln Gly Ser 
        995                 1000                 1005             


Ile Thr  Thr Pro Gly Ser Ile  Ala Leu Ala Gln Ala  Gln Ala Gln 
    1010                 1015                 1020             


Ala Gln  Val Pro Ala Lys Ala  Pro Leu Ala Gly Gln  Val Ser Thr 
    1025                 1030                 1035             


Met Val  Thr Thr Ser Thr Thr  Thr Thr Val Ala Lys  Thr Val Thr 
    1040                 1045                 1050             


Val Thr  Arg Pro Thr Gly Val  Ser Phe Lys Lys Asp  Val Pro Pro 
    1055                 1060                 1065             


Ser Ile  Asn Thr Thr Asn Ile  Asp Thr Leu Leu Val  Ala Thr Asp 
    1070                 1075                 1080             


Gln Thr  Glu Arg Ile Val Glu  Pro Pro Glu Asn Ile  Gln Glu Lys 
    1085                 1090                 1095             


Ile Ala  Phe Ile Phe Asn Asn  Leu Ser Gln Ser Asn  Met Thr Gln 
    1100                 1105                 1110             


Lys Val  Glu Glu Leu Lys Glu  Thr Val Lys Glu Glu  Phe Met Pro 
    1115                 1120                 1125             


Trp Val  Ser Gln Tyr Leu Val  Met Lys Arg Val Ser  Ile Glu Pro 
    1130                 1135                 1140             


Asn Phe  His Ser Leu Tyr Ser  Asn Phe Leu Asp Thr  Leu Lys Asn 
    1145                 1150                 1155             


Pro Glu  Phe Asn Lys Met Val  Leu Asn Glu Thr Tyr  Arg Asn Ile 
    1160                 1165                 1170             


Lys Val  Leu Leu Thr Ser Asp  Lys Ala Ala Ala Asn  Phe Ser Asp 
    1175                 1180                 1185             


Arg Ser  Leu Leu Lys Asn Leu  Gly His Trp Leu Gly  Met Ile Thr 
    1190                 1195                 1200             


Leu Ala  Lys Asn Lys Pro Ile  Leu His Thr Asp Leu  Asp Val Lys 
    1205                 1210                 1215             


Ser Leu  Leu Leu Glu Ala Tyr  Val Lys Gly Gln Gln  Glu Leu Leu 
    1220                 1225                 1230             


Tyr Val  Val Pro Phe Val Ala  Lys Val Leu Glu Ser  Ser Ile Arg 
    1235                 1240                 1245             


Ser Val  Val Phe Arg Pro Pro  Asn Pro Trp Thr Met  Ala Ile Met 
    1250                 1255                 1260             


Asn Val  Leu Ala Glu Leu His  Gln Glu His Asp Leu  Lys Leu Asn 
    1265                 1270                 1275             


Leu Lys  Phe Glu Ile Glu Val  Leu Cys Lys Asn Leu  Ala Leu Asp 
    1280                 1285                 1290             


Ile Asn  Glu Leu Lys Pro Gly  Asn Leu Leu Lys Asp  Lys Asp Arg 
    1295                 1300                 1305             


Leu Lys  Asn Leu Asp Glu Gln  Leu Ser Ala Pro Lys  Lys Asp Val 
    1310                 1315                 1320             


Lys Gln  Pro Glu Glu Leu Pro  Pro Ile Thr Thr Thr  Thr Thr Ser 
    1325                 1330                 1335             


Thr Thr  Pro Ala Thr Asn Thr  Thr Cys Thr Ala Thr  Val Pro Pro 
    1340                 1345                 1350             


Gln Pro  Gln Tyr Ser Tyr His  Asp Ile Asn Val Tyr  Ser Leu Ala 
    1355                 1360                 1365             


Gly Leu  Ala Pro His Ile Thr  Leu Asn Pro Thr Ile  Pro Leu Phe 
    1370                 1375                 1380             


Gln Ala  His Pro Gln Leu Lys  Gln Cys Val Arg Gln  Ala Ile Glu 
    1385                 1390                 1395             


Arg Ala  Val Gln Glu Leu Val  His Pro Val Val Asp  Arg Ser Ile 
    1400                 1405                 1410             


Lys Ile  Ala Met Thr Thr Cys  Glu Gln Ile Val Arg  Lys Asp Phe 
    1415                 1420                 1425             


Ala Leu  Asp Ser Glu Glu Ser  Arg Met Arg Ile Ala  Ala His His 
    1430                 1435                 1440             


Met Met  Arg Asn Leu Thr Ala  Gly Met Ala Met Ile  Thr Cys Arg 
    1445                 1450                 1455             


Glu Pro  Leu Leu Met Ser Ile  Ser Thr Asn Leu Lys  Asn Ser Phe 
    1460                 1465                 1470             


Ala Ser  Ala Leu Arg Thr Ala  Ser Pro Gln Gln Arg  Glu Met Met 
    1475                 1480                 1485             


Asp Gln  Ala Ala Ala Gln Leu  Ala Gln Asp Asn Cys  Glu Leu Ala 
    1490                 1495                 1500             


Cys Cys  Phe Ile Gln Lys Thr  Ala Val Glu Lys Ala  Gly Pro Glu 
    1505                 1510                 1515             


Met Asp  Lys Arg Leu Ala Thr  Glu Phe Glu Leu Arg  Lys His Ala 
    1520                 1525                 1530             


Arg Gln  Glu Gly Arg Arg Tyr  Cys Asp Pro Val Val  Leu Thr Tyr 
    1535                 1540                 1545             


Gln Ala  Glu Arg Met Pro Glu  Gln Ile Arg Leu Lys  Val Gly Gly 
    1550                 1555                 1560             


Val Asp  Pro Lys Gln Leu Ala  Val Tyr Glu Glu Phe  Ala Arg Asn 
    1565                 1570                 1575             


Val Pro  Gly Phe Leu Pro Thr  Asn Asp Leu Ser Gln  Pro Thr Gly 
    1580                 1585                 1590             


Phe Leu  Ala Gln Pro Met Lys  Gln Ala Trp Ala Thr  Asp Asp Val 
    1595                 1600                 1605             


Ala Gln  Ile Tyr Asp Lys Cys  Ile Thr Glu Leu Glu  Gln His Leu 
    1610                 1615                 1620             


His Ala  Ile Pro Pro Thr Leu  Ala Met Asn Pro Gln  Ala Gln Ala 
    1625                 1630                 1635             


Leu Arg  Ser Leu Leu Glu Val  Val Val Leu Ser Arg  Asn Ser Arg 
    1640                 1645                 1650             


Asp Ala  Ile Ala Ala Leu Gly  Leu Leu Gln Lys Ala  Val Glu Gly 
    1655                 1660                 1665             


Leu Leu  Asp Ala Thr Ser Gly  Ala Asp Ala Asp Leu  Leu Leu Arg 
    1670                 1675                 1680             


Tyr Arg  Glu Cys His Leu Leu  Val Leu Lys Ala Leu  Gln Asp Gly 
    1685                 1690                 1695             


Arg Ala  Tyr Gly Ser Pro Trp  Cys Asn Lys Gln Ile  Thr Arg Cys 
    1700                 1705                 1710             


Leu Ile  Glu Cys Arg Asp Glu  Tyr Lys Tyr Asn Val  Glu Ala Val 
    1715                 1720                 1725             


Glu Leu  Leu Ile Arg Asn His  Leu Val Asn Met Gln  Gln Tyr Asp 
    1730                 1735                 1740             


Leu His  Leu Ala Gln Ser Met  Glu Asn Gly Leu Asn  Tyr Met Ala 
    1745                 1750                 1755             


Val Ala  Phe Ala Met Gln Leu  Val Lys Ile Leu Leu  Val Asp Glu 
    1760                 1765                 1770             


Arg Ser  Val Ala His Val Thr  Glu Ala Asp Leu Phe  His Thr Ile 
    1775                 1780                 1785             


Glu Thr  Leu Met Arg Ile Asn  Ala His Ser Arg Gly  Asn Ala Pro 
    1790                 1795                 1800             


Glu Gly  Leu Pro Gln Leu Met  Glu Val Val Arg Ser  Asn Tyr Glu 
    1805                 1810                 1815             


Ala Met  Ile Asp Arg Ala His  Gly Gly Pro Asn Phe  Met Met His 
    1820                 1825                 1830             


Ser Gly  Ile Ser Gln Ala Ser  Glu Tyr Asp Asp Pro  Pro Gly Leu 
    1835                 1840                 1845             


Arg Glu  Lys Ala Glu Tyr Leu  Leu Arg Glu Trp Val  Asn Leu Tyr 
    1850                 1855                 1860             


His Ser  Ala Ala Ala Gly Arg  Asp Ser Thr Lys Ala  Phe Ser Ala 
    1865                 1870                 1875             


Phe Val  Gly Gln Met His Gln  Gln Gly Ile Leu Lys  Thr Asp Asp 
    1880                 1885                 1890             


Leu Ile  Thr Arg Phe Phe Arg  Leu Cys Thr Glu Met  Cys Val Glu 
    1895                 1900                 1905             


Ile Ser  Tyr Arg Ala Gln Ala  Glu Gln Gln His Asn  Pro Ala Ala 
    1910                 1915                 1920             


Asn Pro  Thr Met Ile Arg Ala  Lys Cys Tyr His Asn  Leu Asp Ala 
    1925                 1930                 1935             


Phe Val  Arg Leu Ile Ala Leu  Leu Val Lys His Ser  Gly Glu Ala 
    1940                 1945                 1950             


Thr Asn  Thr Val Thr Lys Ile  Asn Leu Leu Asn Lys  Val Leu Gly 
    1955                 1960                 1965             


Ile Val  Val Gly Val Leu Leu  Gln Asp His Asp Val  Arg Gln Ser 
    1970                 1975                 1980             


Glu Phe  Gln Gln Leu Pro Tyr  His Arg Ile Phe Ile  Met Leu Leu 
    1985                 1990                 1995             


Leu Glu  Leu Asn Ala Pro Glu  His Val Leu Glu Thr  Ile Asn Phe 
    2000                 2005                 2010             


Gln Thr  Leu Thr Ala Phe Cys  Asn Thr Phe His Ile  Leu Arg Pro 
    2015                 2020                 2025             


Thr Lys  Ala Pro Gly Phe Val  Tyr Ala Trp Leu Glu  Leu Ile Ser 
    2030                 2035                 2040             


His Arg  Ile Phe Ile Ala Arg  Met Leu Ala His Thr  Pro Gln Gln 
    2045                 2050                 2055             


Lys Gly  Trp Pro Met Tyr Ala  Gln Leu Leu Ile Asp  Leu Phe Lys 
    2060                 2065                 2070             


Tyr Leu  Ala Pro Phe Leu Arg  Asn Val Glu Leu Thr  Lys Pro Met 
    2075                 2080                 2085             


Gln Ile  Leu Tyr Lys Gly Thr  Leu Arg Val Leu Leu  Val Leu Leu 
    2090                 2095                 2100             


His Asp  Phe Pro Glu Phe Leu  Cys Asp Tyr His Tyr  Gly Phe Cys 
    2105                 2110                 2115             


Asp Val  Ile Pro Pro Asn Cys  Ile Gln Leu Arg Asn  Leu Ile Leu 
    2120                 2125                 2130             


Ser Ala  Phe Pro Arg Asn Met  Arg Leu Pro Asp Pro  Phe Thr Pro 
    2135                 2140                 2145             


Asn Leu  Lys Val Asp Met Leu  Ser Glu Ile Asn Ile  Ala Pro Arg 
    2150                 2155                 2160             


Ile Leu  Thr Asn Phe Thr Gly  Val Met Pro Pro Gln  Phe Lys Lys 
    2165                 2170                 2175             


Asp Leu  Asp Ser Tyr Leu Lys  Thr Arg Ser Pro Val  Thr Phe Leu 
    2180                 2185                 2190             


Ser Asp  Leu Arg Ser Asn Leu  Gln Val Ser Asn Glu  Pro Gly Asn 
    2195                 2200                 2205             


Arg Tyr  Asn Leu Gln Leu Ile  Asn Ala Leu Val Leu  Tyr Val Gly 
    2210                 2215                 2220             


Thr Gln  Ala Ile Ala His Ile  His Asn Lys Gly Ser  Thr Pro Ser 
    2225                 2230                 2235             


Met Ser  Thr Ile Thr His Ser  Ala His Met Asp Ile  Phe Gln Asn 
    2240                 2245                 2250             


Leu Ala  Val Asp Leu Asp Thr  Glu Gly Arg Tyr Leu  Phe Leu Asn 
    2255                 2260                 2265             


Ala Ile  Ala Asn Gln Leu Arg  Tyr Pro Asn Ser His  Thr His Tyr 
    2270                 2275                 2280             


Phe Ser  Cys Thr Met Leu Tyr  Leu Phe Ala Glu Ala  Asn Thr Glu 
    2285                 2290                 2295             


Ala Ile  Gln Glu Gln Ile Thr  Arg Val Leu Leu Glu  Arg Leu Ile 
    2300                 2305                 2310             


Val Asn  Arg Pro His Pro Trp  Gly Leu Leu Ile Thr  Phe Ile Glu 
    2315                 2320                 2325             


Leu Ile  Lys Asn Pro Ala Phe  Lys Phe Trp Asn His  Glu Phe Val 
    2330                 2335                 2340             


His Cys  Ala Pro Glu Ile Glu  Lys Leu Phe Gln Ser  Val Ala Gln 
    2345                 2350                 2355             


Cys Cys  Met Gly Gln Lys Gln  Ala Gln Gln Val Met  Glu Gly Thr 
    2360                 2365                 2370             


Gly Ala  Ser 
    2375     


<210>  4200
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  4200

Met Ala Pro Gln Asn Leu Ser Thr Phe Cys Leu Leu Leu Leu Tyr Leu 
1               5                   10                  15      


Ile Gly Ala Val Ile Ala Gly Arg Asp Phe Tyr Lys Ile Leu Gly Val 
            20                  25                  30          


Pro Arg Ser Ala Ser Ile Lys Asp Ile Lys Lys Ala Tyr Arg Lys Leu 
        35                  40                  45              


Ala Leu Gln Leu His Pro Asp Arg Asn Pro Asp Asp Pro Gln Ala Gln 
    50                  55                  60                  


Glu Lys Phe Gln Asp Leu Gly Ala Ala Tyr Glu Val Leu Ser Asp Ser 
65                  70                  75                  80  


Glu Lys Arg Lys Gln Tyr Asp Thr Tyr Gly Glu Glu Gly Leu Lys Asp 
                85                  90                  95      


Gly His Gln Ser Ser His Gly Asp Ile Phe Ser His Phe Phe Gly Asp 
            100                 105                 110         


Phe Gly Phe Met Phe Gly Gly Thr Pro Arg Gln Gln Asp Arg Asn Ile 
        115                 120                 125             


Pro Arg Gly Ser Asp Ile Ile Val Asp Leu Glu Val Thr Leu Glu Glu 
    130                 135                 140                 


Val Tyr Ala Gly Asn Phe Val Glu Val Val Arg Asn Lys Pro Val Ala 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Arg Lys Cys Asn Cys Arg Gln Glu Met Arg 
                165                 170                 175     


Thr Thr Gln Leu Gly Pro Gly Arg Phe Gln Met Thr Gln Glu Val Val 
            180                 185                 190         


Cys Asp Glu Cys Pro Asn Val Lys Leu Val Asn Glu Glu Arg Thr Leu 
        195                 200                 205             


Glu Val Glu Ile Glu Pro Gly Val Arg Asp Gly Met Glu Tyr Pro Phe 
    210                 215                 220                 


Ile Gly Glu Gly Glu Pro His Val Asp Gly Glu Pro Gly Asp Leu Arg 
225                 230                 235                 240 


Phe Arg Ile Lys Val Val Lys His Pro Ile Phe Glu Arg Arg Gly Asp 
                245                 250                 255     


Asp Leu Tyr Thr Asn Val Thr Ile Ser Leu Val Glu Ser Leu Val Gly 
            260                 265                 270         


Phe Glu Met Asp Ile Thr His Leu Asp Gly His Lys Val His Ile Ser 
        275                 280                 285             


Arg Asp Lys Ile Thr Arg Pro Gly Ala Lys Leu Trp Lys Lys Gly Glu 
    290                 295                 300                 


Gly Leu Pro Asn Phe Asp Asn Asn Asn Ile Lys Gly Ser Leu Ile Ile 
305                 310                 315                 320 


Thr Phe Asp Val Asp Phe Pro Lys Glu Gln Leu Thr Glu Glu Ala Arg 
                325                 330                 335     


Glu Gly Ile Lys Gln Leu Leu Lys Gln Gly Ser Val Gln Lys Val Tyr 
            340                 345                 350         


Asn Gly Leu Gln Gly Tyr 
        355             


<210>  4201
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  4201

Met Asn Arg Ala Phe Ser Arg Lys Lys Asp Lys Thr Trp Met His Thr 
1               5                   10                  15      


Pro Glu Ala Leu Ser Lys His Phe Ile Pro Tyr Asn Ala Lys Phe Leu 
            20                  25                  30          


Gly Ser Thr Glu Val Glu Gln Pro Lys Gly Thr Glu Val Val Arg Asp 
        35                  40                  45              


Ala Val Arg Lys Leu Lys Phe Ala Arg His Ile Lys Lys Ser Glu Gly 
    50                  55                  60                  


Gln Lys Ile Pro Lys Val Glu Leu Gln Ile Ser Ile Tyr Gly Val Lys 
65                  70                  75                  80  


Ile Leu Glu Pro Lys Thr Lys Glu Val Gln His Asn Cys Gln Leu His 
                85                  90                  95      


Arg Ile Ser Phe Cys Ala Asp Asp Lys Thr Asp Lys Arg Ile Phe Thr 
            100                 105                 110         


Phe Ile Cys Lys Asp Ser Glu Ser Asn Lys His Leu Cys Tyr Val Phe 
        115                 120                 125             


Asp Ser Glu Lys Cys Ala Glu Glu Ile Thr Leu Thr Ile Gly Gln Ala 
    130                 135                 140                 


Phe Asp Leu Ala Tyr Arg Lys Phe Leu Glu Ser Gly Gly Lys Asp Val 
145                 150                 155                 160 


Glu Thr Arg Lys Gln Ile Ala Gly Leu Gln Lys Arg Ile Gln Asp Leu 
                165                 170                 175     


Glu Thr Glu Asn Met Glu Leu Lys Asn Lys Val Gln Asp Leu Glu Asn 
            180                 185                 190         


Gln Leu Arg Ile Thr Gln Val Ser Ala Pro Pro Ala Gly Ser Met Thr 
        195                 200                 205             


Pro Lys Ser Pro Ser Thr Asp Ile Phe Asp Met Ile Pro Phe Ser Pro 
    210                 215                 220                 


Ile Ser His Gln Ser Ser Met Pro Thr Arg Asn Gly Thr Gln Pro Pro 
225                 230                 235                 240 


Pro Val Pro Ser Arg Ser Thr Glu Ile Lys Arg Asp Leu Phe Gly Ala 
                245                 250                 255     


Glu Pro Phe Asp Pro Phe Asn Cys Gly Ala Ala Asp Phe Pro Pro Asp 
            260                 265                 270         


Ile Gln Ser Lys Leu Asp Glu Met Gln Glu Gly Phe Lys Met Gly Leu 
        275                 280                 285             


Thr Leu Glu Gly Thr Val Phe Cys Leu Asp Pro Leu Asp Ser Arg Cys 
    290                 295                 300                 


<210>  4202
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  4202

Met Ala Ala Ala Gln Pro Lys Tyr Pro Ala Gly Ala Thr Ala Arg Arg 
1               5                   10                  15      


Leu Ala Arg Gly Cys Trp Ser Ala Leu Trp Asp Tyr Glu Thr Pro Lys 
            20                  25                  30          


Val Ile Val Val Arg Asn Arg Arg Leu Gly Val Leu Tyr Arg Ala Val 
        35                  40                  45              


Gln Leu Leu Ile Leu Leu Tyr Phe Val Trp Tyr Val Phe Ile Val Gln 
    50                  55                  60                  


Lys Ser Tyr Gln Glu Ser Glu Thr Gly Pro Glu Ser Ser Ile Ile Thr 
65                  70                  75                  80  


Lys Val Lys Gly Ile Thr Thr Ser Glu His Lys Val Trp Asp Val Glu 
                85                  90                  95      


Glu Tyr Val Lys Pro Pro Glu Ser Ile Arg Val His Asn Ala Thr Cys 
            100                 105                 110         


Leu Ser Asp Ala Asp Cys Val Ala Gly Glu Leu Asp Met Leu Gly Asn 
        115                 120                 125             


Gly Leu Arg Thr Gly Arg Cys Val Pro Tyr Tyr Gln Gly Pro Ser Lys 
    130                 135                 140                 


Thr Cys Glu Val Phe Gly Trp Cys Pro Val Glu Asp Gly Ala Ser Val 
145                 150                 155                 160 


Ser Gln Phe Leu Gly Thr Met Ala Pro Asn Phe Thr Ile Leu Ile Lys 
                165                 170                 175     


Asn Ser Ile His Tyr Pro Lys Phe His Phe Ser Lys Gly Asn Ile Ala 
            180                 185                 190         


Asp Arg Thr Asp Gly Tyr Leu Lys Arg Cys Thr Phe His Glu Ala Ser 
        195                 200                 205             


Asp Leu Tyr Cys Pro Ile Phe Lys Leu Gly Phe Ile Val Glu Lys Ala 
    210                 215                 220                 


Gly Glu Ser Phe Thr Glu Leu Ala His Lys Gly Gly Val Ile Gly Val 
225                 230                 235                 240 


Ile Ile Asn Trp Asp Cys Asp Leu Asp Leu Pro Ala Ser Glu Cys Asn 
                245                 250                 255     


Pro Lys Tyr Ser Phe Arg Arg Leu Asp Pro Lys His Val Pro Ala Ser 
            260                 265                 270         


Ser Gly Tyr Asn Phe Arg Phe Ala Lys Tyr Tyr Lys Ile Asn Gly Thr 
        275                 280                 285             


Thr Thr Arg Thr Leu Ile Lys Ala Tyr Gly Ile Arg Ile Asp Val Ile 
    290                 295                 300                 


Val His Gly Gln Ala Gly Lys Phe Ser Leu Ile Pro Thr Ile Ile Asn 
305                 310                 315                 320 


Leu Ala Thr Ala Leu Thr Ser Val Gly Val Gly Ser Phe Leu Cys Asp 
                325                 330                 335     


Trp Ile Leu Leu Thr Phe Met Asn Lys Asn Lys Val Tyr Ser His Lys 
            340                 345                 350         


Lys Phe Asp Lys Val Cys Thr Pro Ser His Pro Ser Gly Ser Trp Pro 
        355                 360                 365             


Val Thr Leu Ala Arg Val Leu Gly Gln Ala Pro Pro Glu Pro Gly His 
    370                 375                 380                 


Arg Ser Glu Asp Gln His Pro Ser Pro Pro Ser Gly Gln Glu Gly Gln 
385                 390                 395                 400 


Gln Gly Ala Glu Cys Gly Pro Ala Phe Pro Pro Leu Arg Pro Cys Pro 
                405                 410                 415     


Ile Ser Ala Pro Ser Glu Gln Met Val Asp Thr Pro Ala Ser Glu Pro 
            420                 425                 430         


Ala Gln Ala Ser Thr Pro Thr Asp Pro Lys Gly Leu Ala Gln Leu 
        435                 440                 445         


<210>  4203
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  4203

Met Ala Trp Asn Thr Asn Leu Arg Trp Arg Leu Pro Leu Thr Cys Leu 
1               5                   10                  15      


Leu Leu Gln Val Ile Met Val Ile Leu Phe Gly Val Phe Val Arg Tyr 
            20                  25                  30          


Asp Phe Glu Ala Asp Ala His Trp Trp Ser Glu Arg Thr His Lys Asn 
        35                  40                  45              


Leu Ser Asp Met Glu Asn Glu Phe Tyr Tyr Arg Tyr Pro Ser Phe Gln 
    50                  55                  60                  


Asp Val His Val Met Val Phe Val Gly Phe Gly Phe Leu Met Thr Phe 
65                  70                  75                  80  


Leu Gln Arg Tyr Gly Phe Ser Ala Val Gly Phe Asn Phe Leu Leu Ala 
                85                  90                  95      


Ala Phe Gly Ile Gln Trp Ala Leu Leu Met Gln Gly Trp Phe His Phe 
            100                 105                 110         


Leu Gln Asp Arg Tyr Ile Val Val Gly Val Glu Asn Leu Ile Asn Ala 
        115                 120                 125             


Asp Phe Cys Val Ala Ser Val Cys Val Ala Phe Gly Ala Val Leu Gly 
    130                 135                 140                 


Lys Val Ser Pro Ile Gln Leu Leu Ile Met Thr Phe Phe Gln Val Thr 
145                 150                 155                 160 


Leu Phe Ala Val Asn Glu Phe Ile Leu Leu Asn Leu Leu Lys Val Lys 
                165                 170                 175     


Asp Ala Gly Gly Ser Met Thr Ile His Thr Phe Gly Ala Tyr Phe Gly 
            180                 185                 190         


Leu Thr Val Thr Arg Ile Leu Tyr Arg Arg Asn Leu Glu Gln Ser Lys 
        195                 200                 205             


Glu Arg Gln Asn Ser Val Tyr Gln Ser Asp Leu Phe Ala Met Ile Gly 
    210                 215                 220                 


Thr Leu Phe Leu Trp Met Tyr Trp Pro Ser Phe Asn Ser Ala Ile Ser 
225                 230                 235                 240 


Tyr His Gly Asp Ser Gln His Arg Ala Ala Ile Asn Thr Tyr Cys Ser 
                245                 250                 255     


Leu Ala Ala Cys Val Leu Thr Ser Val Ala Ile Ser Ser Ala Leu His 
            260                 265                 270         


Lys Lys Gly Lys Leu Asp Met Val His Ile Gln Asn Ala Thr Leu Ala 
        275                 280                 285             


Gly Gly Val Ala Val Gly Thr Ala Ala Glu Met Met Leu Met Pro Tyr 
    290                 295                 300                 


Gly Ala Leu Ile Ile Gly Phe Val Cys Gly Ile Ile Ser Thr Leu Gly 
305                 310                 315                 320 


Phe Val Tyr Leu Thr Pro Phe Leu Glu Ser Arg Leu His Ile Gln Asp 
                325                 330                 335     


Thr Cys Gly Ile Asn Asn Leu His Gly Ile Pro Gly Ile Ile Gly Gly 
            340                 345                 350         


Ile Val Gly Ala Val Thr Ala Ala Ser Ala Ser Leu Glu Val Tyr Gly 
        355                 360                 365             


Lys Glu Gly Leu Val His Ser Phe Asp Phe Gln Gly Phe Asn Gly Asp 
    370                 375                 380                 


Trp Thr Ala Arg Thr Gln Gly Lys Phe Gln Ile Tyr Gly Leu Leu Val 
385                 390                 395                 400 


Thr Leu Ala Met Ala Leu Met Gly Gly Ile Ile Val Gly Leu Ile Leu 
                405                 410                 415     


Arg Leu Pro Phe Trp Gly Gln Pro Ser Asp Glu Asn Cys Phe Glu Asp 
            420                 425                 430         


Ala Val Tyr Trp Glu Met Pro Glu Gly Asn Ser Thr Val Tyr Ile Pro 
        435                 440                 445             


Glu Asp Pro Thr Phe Lys Pro Ser Gly Pro Ser Val Pro Ser Val Pro 
    450                 455                 460                 


Met Val Ser Pro Leu Pro Met Ala Ser Ser Val Pro Leu Val Pro 
465                 470                 475                 


<210>  4204
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  4204

Met Asp Asn Val Gln Pro Lys Ile Lys His Arg Pro Phe Cys Phe Ser 
1               5                   10                  15      


Val Lys Gly His Val Lys Met Leu Arg Leu Val Phe Ala Leu Val Thr 
            20                  25                  30          


Ala Val Cys Cys Leu Ala Asp Gly Ala Leu Ile Tyr Arg Lys Leu Leu 
        35                  40                  45              


Phe Asn Pro Ser Gly Pro Tyr Gln Lys Lys Pro Val His Glu Lys Lys 
    50                  55                  60                  


Glu Val Leu 
65          


<210>  4205
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  4205

Met Ala Pro Tyr His Ile Arg Lys Tyr Gln Glu Ser Asp Arg Lys Ser 
1               5                   10                  15      


Val Val Gly Leu Leu Ser Arg Gly Met Ala Glu His Ala Pro Ala Thr 
            20                  25                  30          


Phe Arg Arg Leu Leu Lys Leu Pro Arg Thr Leu Ile Leu Leu Leu Gly 
        35                  40                  45              


Gly Ala Leu Ala Leu Leu Leu Val Ser Gly Ser Trp Ile Leu Ala Leu 
    50                  55                  60                  


Val Phe Ser Leu Ser Leu Leu Pro Ala Leu Trp Phe Leu Ala Lys Lys 
65                  70                  75                  80  


Pro Trp Thr Arg Tyr Val Asp Ile Ala Leu Arg Thr Asp Met Ser Asp 
                85                  90                  95      


Ile Thr Lys Ser Tyr Leu Ser Glu Cys Gly Ser Cys Phe Trp Val Gly 
            100                 105                 110         


Glu Ser Glu Glu Lys Val Val Gly Thr Val Gly Ala Leu Pro Val Asp 
        115                 120                 125             


Asp Pro Thr Leu Arg Glu Lys Arg Leu Gln Leu Phe His Leu Ser Val 
    130                 135                 140                 


Asp Asn Glu His Arg Gly Gln Gly Ile Ala Lys Ala Leu Val Arg Thr 
145                 150                 155                 160 


Val Leu Gln Phe Ala Arg Asp Gln Gly Tyr Ser Glu Val Val Leu Asp 
                165                 170                 175     


Thr Ser Asn Ile Gln Leu Ser Ala Met Gly Leu Tyr Gln Ser Leu Gly 
            180                 185                 190         


Phe Lys Lys Thr Gly Gln Ser Phe Phe His Val Trp Ala Arg Leu Val 
        195                 200                 205             


Asp Leu His Thr Val His Phe Ile Tyr His Leu Pro Ser Ala Gln Ala 
    210                 215                 220                 


Gly Arg Leu 
225         


<210>  4206
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  4206

Met Lys Gly Glu Ala Gly His Met Leu His Asn Glu Lys Ser Lys Gln 
1               5                   10                  15      


Glu Gly His Ile Trp Gly Ser Met Arg Arg Thr Ala Phe Ile Leu Gly 
            20                  25                  30          


Ser Gly Leu Leu Ser Phe Val Ala Phe Trp Asn Ser Val Thr Trp His 
        35                  40                  45              


Leu Gln Arg Phe Trp Gly Ala Ser Gly Tyr Phe Trp Gln Ala Gln Trp 
    50                  55                  60                  


Glu Arg Leu Leu Thr Thr Phe Glu Gly Lys Glu Trp Ile Leu Phe Phe 
65                  70                  75                  80  


Ile Gly Ala Ile Gln Val Pro Cys Leu Phe Phe Trp Ser Phe Asn Gly 
                85                  90                  95      


Leu Leu Leu Val Val Asp Thr Thr Gly Lys Pro Asn Phe Ile Ser Arg 
            100                 105                 110         


Tyr Arg Ile Gln Val Gly Lys Asn Glu Pro Val Asp Pro Val Lys Leu 
        115                 120                 125             


Arg Gln Ser Ile Arg Thr Val Leu Phe Asn Gln Cys Met Ile Ser Phe 
    130                 135                 140                 


Pro Met Val Val Phe Leu Tyr Pro Phe Leu Lys Trp Trp Arg Asp Pro 
145                 150                 155                 160 


Cys Arg Arg Glu Leu Pro Thr Phe His Trp Phe Leu Leu Glu Leu Ala 
                165                 170                 175     


Ile Phe Thr Leu Ile Glu Glu Val Leu Phe Tyr Tyr Ser His Arg Leu 
            180                 185                 190         


Leu His His Pro Thr Phe Tyr Lys Lys Ile His Lys Lys His His Glu 
        195                 200                 205             


Trp Thr Ala Pro Ile Gly Val Ile Ser Leu Tyr Ala His Pro Ile Glu 
    210                 215                 220                 


His Ala Val Ser Asn Met Leu Pro Val Ile Val Gly Pro Leu Val Met 
225                 230                 235                 240 


Gly Ser His Leu Ser Ser Ile Thr Met Trp Phe Ser Leu Ala Leu Ile 
                245                 250                 255     


Ile Thr Thr Ile Ser His Cys Gly Tyr His Leu Pro Phe Leu Pro Ser 
            260                 265                 270         


Pro Glu Phe His Asp Tyr His His Leu Lys Phe Asn Gln Cys Tyr Gly 
        275                 280                 285             


Val Leu Gly Val Leu Asp His Leu His Gly Thr Asp Thr Met Phe Lys 
    290                 295                 300                 


Gln Thr Lys Ala Tyr Glu Arg His Val Leu Leu Leu Gly Phe Thr Pro 
305                 310                 315                 320 


Leu Ser Glu Ser Ile Pro Asp Ser Pro Lys Arg Met Glu 
                325                 330             


<210>  4207
<211>  870
<212>  PRT
<213>  Homo sapiens

<400>  4207

Met Gln Ala Ala Val Ala Val Ser Val Pro Phe Leu Leu Leu Cys Val 
1               5                   10                  15      


Leu Gly Thr Cys Pro Pro Ala Arg Cys Gly Gln Ala Gly Asp Ala Ser 
            20                  25                  30          


Leu Met Glu Leu Glu Lys Arg Lys Glu Asn Arg Phe Val Glu Arg Gln 
        35                  40                  45              


Ser Ile Val Pro Leu Arg Leu Ile Tyr Arg Ser Gly Gly Glu Asp Glu 
    50                  55                  60                  


Ser Arg His Asp Ala Leu Asp Thr Arg Val Arg Gly Asp Leu Gly Gly 
65                  70                  75                  80  


Pro Gln Leu Thr His Val Asp Gln Ala Ser Phe Gln Val Asp Ala Phe 
                85                  90                  95      


Gly Thr Ser Phe Ile Leu Asp Val Val Leu Asn His Asp Leu Leu Ser 
            100                 105                 110         


Ser Glu Tyr Ile Glu Arg His Ile Glu His Gly Gly Lys Thr Val Glu 
        115                 120                 125             


Val Lys Gly Gly Glu His Cys Tyr Tyr Gln Gly His Ile Arg Gly Asn 
    130                 135                 140                 


Pro Asp Ser Phe Val Ala Leu Ser Thr Cys His Gly Leu His Gly Met 
145                 150                 155                 160 


Phe Tyr Asp Gly Asn His Thr Tyr Leu Ile Glu Pro Glu Glu Asn Asp 
                165                 170                 175     


Thr Thr Gln Glu Asp Phe His Phe His Ser Val Tyr Lys Ser Arg Leu 
            180                 185                 190         


Phe Glu Phe Ser Leu Asp Asp Leu Pro Ser Glu Phe Gln Gln Val Asn 
        195                 200                 205             


Ile Thr Pro Ser Lys Phe Ile Leu Lys Pro Arg Pro Lys Arg Ser Lys 
    210                 215                 220                 


Arg Gln Leu Arg Arg Tyr Pro Arg Asn Val Glu Glu Glu Thr Lys Tyr 
225                 230                 235                 240 


Ile Glu Leu Met Ile Val Asn Asp His Leu Met Phe Lys Lys His Arg 
                245                 250                 255     


Leu Ser Val Val His Thr Asn Thr Tyr Ala Lys Ser Val Val Asn Met 
            260                 265                 270         


Ala Asp Leu Ile Tyr Lys Asp Gln Leu Lys Thr Arg Ile Val Leu Val 
        275                 280                 285             


Ala Met Glu Thr Trp Ala Thr Asp Asn Lys Phe Ala Ile Ser Glu Asn 
    290                 295                 300                 


Pro Leu Ile Thr Leu Arg Glu Phe Met Lys Tyr Arg Arg Asp Phe Ile 
305                 310                 315                 320 


Lys Glu Lys Ser Asp Ala Val His Leu Phe Ser Gly Ser Gln Phe Glu 
                325                 330                 335     


Ser Ser Arg Ser Gly Ala Ala Tyr Ile Gly Gly Ile Cys Ser Leu Leu 
            340                 345                 350         


Lys Gly Gly Gly Val Asn Glu Phe Gly Lys Thr Asp Leu Met Ala Val 
        355                 360                 365             


Thr Leu Ala Gln Ser Leu Ala His Asn Ile Gly Ile Ile Ser Asp Lys 
    370                 375                 380                 


Arg Lys Leu Ala Ser Gly Glu Cys Lys Cys Glu Asp Thr Trp Ser Gly 
385                 390                 395                 400 


Cys Ile Met Gly Asp Thr Gly Tyr Tyr Leu Pro Lys Lys Phe Thr Gln 
                405                 410                 415     


Cys Asn Ile Glu Glu Tyr His Asp Phe Leu Asn Ser Gly Gly Gly Ala 
            420                 425                 430         


Cys Leu Phe Asn Lys Pro Ser Lys Leu Leu Asp Pro Pro Glu Cys Gly 
        435                 440                 445             


Asn Gly Phe Ile Glu Thr Gly Glu Glu Cys Asp Cys Gly Thr Pro Ala 
    450                 455                 460                 


Glu Cys Val Leu Glu Gly Ala Glu Cys Cys Lys Lys Cys Thr Leu Thr 
465                 470                 475                 480 


Gln Asp Ser Gln Cys Ser Asp Gly Leu Cys Cys Lys Lys Cys Lys Phe 
                485                 490                 495     


Gln Pro Met Gly Thr Val Cys Arg Glu Ala Val Asn Asp Cys Asp Ile 
            500                 505                 510         


Arg Glu Thr Cys Ser Gly Asn Ser Ser Gln Cys Ala Pro Asn Ile His 
        515                 520                 525             


Lys Met Asp Gly Tyr Ser Cys Asp Gly Val Gln Gly Ile Cys Phe Gly 
    530                 535                 540                 


Gly Arg Cys Lys Thr Arg Asp Arg Gln Cys Lys Tyr Ile Trp Gly Gln 
545                 550                 555                 560 


Lys Val Thr Ala Ser Asp Lys Tyr Cys Tyr Glu Lys Leu Asn Ile Glu 
                565                 570                 575     


Gly Thr Glu Lys Gly Asn Cys Gly Lys Asp Lys Asp Thr Trp Ile Gln 
            580                 585                 590         


Cys Asn Lys Arg Asp Val Leu Cys Gly Tyr Leu Leu Cys Thr Asn Ile 
        595                 600                 605             


Gly Asn Ile Pro Arg Leu Gly Glu Leu Asp Gly Glu Ile Thr Ser Thr 
    610                 615                 620                 


Leu Val Val Gln Gln Gly Arg Thr Leu Asn Cys Ser Gly Gly His Val 
625                 630                 635                 640 


Lys Leu Glu Glu Asp Val Asp Leu Gly Tyr Val Glu Asp Gly Thr Pro 
                645                 650                 655     


Cys Gly Pro Gln Met Met Cys Leu Glu His Arg Cys Leu Pro Val Ala 
            660                 665                 670         


Ser Phe Asn Phe Ser Thr Cys Leu Ser Ser Lys Glu Gly Thr Ile Cys 
        675                 680                 685             


Ser Gly Asn Gly Val Cys Ser Asn Glu Leu Lys Cys Val Cys Asn Arg 
    690                 695                 700                 


His Trp Ile Gly Ser Asp Cys Asn Thr Tyr Phe Pro His Asn Asp Asp 
705                 710                 715                 720 


Ala Lys Thr Gly Ile Thr Leu Ser Gly Asn Gly Val Ala Gly Thr Asn 
                725                 730                 735     


Ile Ile Ile Gly Ile Ile Ala Gly Thr Ile Leu Val Leu Ala Leu Ile 
            740                 745                 750         


Leu Gly Ile Thr Ala Trp Gly Tyr Lys Asn Tyr Arg Glu Gln Arg Ser 
        755                 760                 765             


Asn Gly Leu Ser His Ser Trp Ser Glu Arg Ile Pro Asp Thr Lys His 
    770                 775                 780                 


Ile Ser Asp Ile Cys Glu Asn Gly Arg Pro Arg Ser Asn Ser Trp Gln 
785                 790                 795                 800 


Gly Asn Leu Gly Gly Asn Lys Lys Lys Ile Arg Gly Lys Arg Phe Arg 
                805                 810                 815     


Pro Arg Ser Asn Ser Thr Glu Thr Leu Ser Pro Ala Lys Ser Pro Ser 
            820                 825                 830         


Ser Ser Thr Gly Ser Ile Ala Ser Ser Arg Lys Tyr Pro Tyr Pro Met 
        835                 840                 845             


Pro Pro Leu Pro Asp Glu Asp Lys Lys Val Asn Arg Gln Ser Ala Arg 
    850                 855                 860                 


Leu Trp Glu Thr Ser Ile 
865                 870 


<210>  4208
<211>  367
<212>  PRT
<213>  Homo sapiens

<400>  4208

Met Ala Pro Ser Gly Pro Gly Ser Ser Ala Arg Arg Arg Cys Arg Arg 
1               5                   10                  15      


Val Leu Tyr Trp Ile Pro Val Val Phe Ile Thr Leu Leu Leu Gly Trp 
            20                  25                  30          


Ser Tyr Tyr Ala Tyr Ala Ile Gln Leu Cys Ile Val Ser Met Glu Asn 
        35                  40                  45              


Thr Gly Glu Gln Val Val Cys Leu Met Ala Tyr His Leu Leu Phe Ala 
    50                  55                  60                  


Met Phe Val Trp Ser Tyr Trp Lys Thr Ile Phe Thr Leu Pro Met Asn 
65                  70                  75                  80  


Pro Ser Lys Glu Phe His Leu Ser Tyr Ala Glu Lys Asp Leu Leu Glu 
                85                  90                  95      


Arg Glu Pro Arg Gly Glu Ala His Gln Glu Val Leu Arg Arg Ala Ala 
            100                 105                 110         


Lys Asp Leu Pro Ile Tyr Thr Arg Thr Met Ser Gly Ala Ile Arg Tyr 
        115                 120                 125             


Cys Asp Arg Cys Gln Leu Ile Lys Pro Asp Arg Cys His His Cys Ser 
    130                 135                 140                 


Val Cys Asp Lys Cys Ile Leu Lys Met Asp His His Cys Pro Trp Val 
145                 150                 155                 160 


Asn Asn Cys Val Gly Phe Ser Asn Tyr Lys Phe Phe Leu Leu Phe Leu 
                165                 170                 175     


Ala Tyr Ser Leu Leu Tyr Cys Leu Phe Ile Ala Ala Thr Asp Leu Gln 
            180                 185                 190         


Tyr Phe Ile Lys Phe Trp Thr Asn Gly Leu Pro Asp Thr Gln Ala Lys 
        195                 200                 205             


Phe His Ile Met Phe Leu Phe Phe Ala Ala Ala Met Phe Ser Val Ser 
    210                 215                 220                 


Leu Ser Ser Leu Phe Gly Tyr His Cys Trp Leu Val Ser Lys Asn Lys 
225                 230                 235                 240 


Ser Thr Leu Glu Ala Phe Arg Ser Pro Val Phe Arg His Gly Thr Asp 
                245                 250                 255     


Lys Asn Gly Phe Ser Leu Gly Phe Ser Lys Asn Met Arg Gln Val Phe 
            260                 265                 270         


Gly Asp Glu Lys Lys Tyr Trp Leu Leu Pro Ile Phe Ser Ser Leu Gly 
        275                 280                 285             


Asp Gly Cys Ser Phe Pro Thr Cys Leu Val Asn Gln Asp Pro Glu Gln 
    290                 295                 300                 


Ala Ser Thr Pro Ala Gly Leu Asn Ser Thr Ala Lys Asn Leu Glu Asn 
305                 310                 315                 320 


His Gln Phe Pro Ala Lys Pro Leu Arg Glu Ser Gln Ser His Leu Leu 
                325                 330                 335     


Thr Asp Ser Gln Ser Trp Thr Glu Ser Ser Ile Asn Pro Gly Lys Cys 
            340                 345                 350         


Lys Ala Gly Met Ser Asn Pro Ala Leu Thr Met Glu Asn Glu Thr 
        355                 360                 365         


<210>  4209
<211>  722
<212>  PRT
<213>  Homo sapiens

<400>  4209

Met Pro Leu His Gln Leu Gly Asp Lys Pro Leu Thr Phe Pro Ser Pro 
1               5                   10                  15      


Asn Ser Ala Met Glu Asn Gly Leu Asp His Thr Pro Pro Ser Arg Arg 
            20                  25                  30          


Ala Ser Pro Gly Thr Pro Leu Ser Pro Gly Ser Leu Arg Ser Ala Ala 
        35                  40                  45              


His Ser Pro Leu Asp Thr Ser Lys Gln Pro Leu Cys Gln Leu Trp Ala 
    50                  55                  60                  


Glu Lys His Gly Ala Arg Gly Thr His Glu Val Arg Tyr Val Ser Ala 
65                  70                  75                  80  


Gly Gln Ser Val Ala Cys Gly Trp Trp Ala Phe Ala Pro Pro Cys Leu 
                85                  90                  95      


Gln Val Leu Asn Thr Pro Lys Gly Ile Leu Phe Phe Leu Cys Ala Ala 
            100                 105                 110         


Ala Phe Leu Gln Gly Met Thr Val Asn Gly Phe Ile Asn Thr Val Ile 
        115                 120                 125             


Thr Ser Leu Glu Arg Arg Tyr Asp Leu His Ser Tyr Gln Ser Gly Leu 
    130                 135                 140                 


Ile Ala Ser Ser Tyr Asp Ile Ala Ala Cys Leu Cys Leu Thr Phe Val 
145                 150                 155                 160 


Ser Tyr Phe Gly Gly Ser Gly His Lys Pro Arg Trp Leu Gly Trp Gly 
                165                 170                 175     


Val Leu Leu Met Gly Thr Gly Ser Leu Val Phe Ala Leu Pro His Phe 
            180                 185                 190         


Thr Ala Gly Arg Tyr Glu Val Glu Leu Asp Ala Gly Val Arg Thr Cys 
        195                 200                 205             


Pro Ala Asn Pro Gly Ala Val Cys Ala Asp Ser Thr Ser Gly Leu Ser 
    210                 215                 220                 


Arg Tyr Gln Leu Val Phe Met Leu Gly Gln Phe Leu His Gly Val Gly 
225                 230                 235                 240 


Ala Thr Pro Leu Tyr Thr Leu Gly Val Thr Tyr Leu Asp Glu Asn Val 
                245                 250                 255     


Lys Ser Ser Cys Ser Pro Val Tyr Ile Ala Ile Phe Tyr Thr Ala Ala 
            260                 265                 270         


Ile Leu Gly Pro Ala Ala Gly Tyr Leu Ile Gly Gly Ala Leu Leu Asn 
        275                 280                 285             


Ile Tyr Thr Glu Met Gly Arg Arg Thr Glu Leu Thr Thr Glu Ser Pro 
    290                 295                 300                 


Leu Trp Val Gly Ala Trp Trp Val Gly Phe Leu Gly Ser Gly Ala Ala 
305                 310                 315                 320 


Ala Phe Phe Thr Ala Val Pro Ile Leu Gly Tyr Pro Arg Gln Leu Pro 
                325                 330                 335     


Gly Ser Gln Arg Tyr Ala Val Met Arg Ala Ala Glu Met His Gln Leu 
            340                 345                 350         


Lys Asp Ser Ser Arg Gly Glu Ala Ser Asn Pro Asp Phe Gly Lys Thr 
        355                 360                 365             


Ile Arg Asp Leu Pro Leu Ser Ile Trp Leu Leu Leu Lys Asn Pro Thr 
    370                 375                 380                 


Phe Ile Leu Leu Cys Leu Ala Gly Ala Thr Glu Ala Thr Leu Ile Thr 
385                 390                 395                 400 


Gly Met Ser Thr Phe Ser Pro Lys Phe Leu Glu Ser Gln Phe Ser Leu 
                405                 410                 415     


Ser Ala Ser Glu Ala Ala Thr Leu Phe Gly Tyr Leu Val Val Pro Ala 
            420                 425                 430         


Gly Gly Gly Gly Thr Phe Leu Gly Gly Phe Phe Val Asn Lys Leu Arg 
        435                 440                 445             


Leu Arg Gly Ser Ala Val Ile Lys Phe Cys Leu Phe Cys Thr Val Val 
    450                 455                 460                 


Ser Leu Leu Gly Ile Leu Val Phe Ser Leu His Cys Pro Ser Val Pro 
465                 470                 475                 480 


Met Ala Gly Val Thr Ala Ser Tyr Gly Gly Ser Leu Leu Pro Glu Gly 
                485                 490                 495     


His Leu Asn Leu Thr Ala Pro Cys Asn Ala Ala Cys Ser Cys Gln Pro 
            500                 505                 510         


Glu His Tyr Ser Pro Val Cys Gly Ser Asp Gly Leu Met Tyr Phe Ser 
        515                 520                 525             


Leu Cys His Ala Gly Cys Pro Ala Ala Thr Glu Thr Asn Val Asp Gly 
    530                 535                 540                 


Gln Lys Val Tyr Arg Asp Cys Ser Cys Ile Pro Gln Asn Leu Ser Ser 
545                 550                 555                 560 


Gly Phe Gly His Ala Thr Ala Gly Lys Cys Thr Ser Thr Cys Gln Arg 
                565                 570                 575     


Lys Pro Leu Leu Leu Val Phe Ile Phe Val Val Ile Phe Phe Thr Phe 
            580                 585                 590         


Leu Ser Ser Ile Pro Ala Leu Thr Ala Thr Leu Arg Cys Val Arg Asp 
        595                 600                 605             


Pro Gln Arg Ser Phe Ala Leu Gly Ile Gln Trp Ile Val Val Arg Ile 
    610                 615                 620                 


Leu Gly Gly Ile Pro Gly Pro Ile Ala Phe Gly Trp Val Ile Asp Lys 
625                 630                 635                 640 


Ala Cys Leu Leu Trp Gln Asp Gln Cys Gly Gln Gln Gly Ser Cys Leu 
                645                 650                 655     


Val Tyr Gln Asn Ser Ala Met Ser Arg Tyr Ile Leu Ile Met Gly Leu 
            660                 665                 670         


Leu Tyr Lys Val Leu Gly Val Leu Phe Phe Ala Ile Ala Cys Phe Leu 
        675                 680                 685             


Tyr Lys Pro Leu Ser Glu Ser Ser Asp Gly Leu Glu Thr Cys Leu Pro 
    690                 695                 700                 


Ser Gln Ser Ser Ala Pro Asp Ser Ala Thr Asp Ser Gln Leu Gln Ser 
705                 710                 715                 720 


Ser Val 
        


<210>  4210
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  4210

Met Pro Ser Pro Gly Thr Val Cys Ser Leu Leu Leu Leu Gly Met Leu 
1               5                   10                  15      


Trp Leu Asp Leu Ala Met Ala Gly Ser Ser Phe Leu Ser Pro Glu His 
            20                  25                  30          


Gln Arg Val Gln Gln Arg Lys Glu Ser Lys Lys Pro Pro Ala Lys Leu 
        35                  40                  45              


Gln Pro Arg Ala Leu Ala Gly Trp Leu Arg Pro Glu Asp Gly Gly Gln 
    50                  55                  60                  


Ala Glu Gly Ala Glu Asp Glu Leu Glu Val Arg Phe Asn Ala Pro Phe 
65                  70                  75                  80  


Asp Val Gly Ile Lys Leu Ser Gly Val Gln Tyr Gln Gln His Ser Gln 
                85                  90                  95      


Ala Leu Gly Lys Phe Leu Gln Asp Ile Leu Trp Glu Glu Ala Lys Glu 
            100                 105                 110         


Ala Pro Ala Asp Lys 
        115         


<210>  4211
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  4211

Met Ser Pro Ser Pro Thr Ala Leu Phe Cys Leu Gly Leu Cys Leu Gly 
1               5                   10                  15      


Arg Val Pro Ala Gln Ser Gly Pro Leu Pro Lys Pro Ser Leu Gln Ala 
            20                  25                  30          


Leu Pro Ser Ser Leu Val Pro Leu Glu Lys Pro Val Thr Leu Arg Cys 
        35                  40                  45              


Gln Gly Pro Pro Gly Val Asp Leu Tyr Arg Leu Glu Lys Leu Ser Ser 
    50                  55                  60                  


Ser Arg Tyr Gln Asp Gln Ala Val Leu Phe Ile Pro Ala Met Lys Arg 
65                  70                  75                  80  


Ser Leu Ala Gly Arg Tyr Arg Cys Ser Tyr Gln Asn Gly Ser Leu Trp 
                85                  90                  95      


Ser Leu Pro Ser Asp Gln Leu Glu Leu Val Ala Thr Gly Val Phe Ala 
            100                 105                 110         


Lys Pro Ser Leu Ser Ala Gln Pro Gly Pro Ala Val Ser Ser Gly Gly 
        115                 120                 125             


Asp Val Thr Leu Gln Cys Gln Thr Arg Tyr Gly Phe Asp Gln Phe Ala 
    130                 135                 140                 


Leu Tyr Lys Glu Gly Asp Pro Ala Pro Tyr Lys Asn Pro Glu Arg Trp 
145                 150                 155                 160 


Tyr Arg Ala Ser Phe Pro Ile Ile Thr Val Thr Ala Ala His Ser Gly 
                165                 170                 175     


Thr Tyr Arg Cys Tyr Ser Phe Ser Ser Arg Asp Pro Tyr Leu Trp Ser 
            180                 185                 190         


Ala Pro Ser Asp Pro Leu Glu Leu Val Val Thr Gly Thr Ser Val Thr 
        195                 200                 205             


Pro Ser Arg Leu Pro Thr Glu Pro Pro Ser Pro Val Ala Glu Phe Ser 
    210                 215                 220                 


Glu Ala Thr Ala Glu Leu Thr Val Ser Phe Thr Asn Glu Val Phe Thr 
225                 230                 235                 240 


Thr Glu Thr Ser Arg Ser Ile Thr Ala Ser Pro Lys Glu Ser Asp Ser 
                245                 250                 255     


Pro Ala Gly Pro Ala Arg Gln Tyr Tyr Thr Lys Gly Asn Leu Val Arg 
            260                 265                 270         


Ile Cys Leu Gly Ala Val Ile Leu Ile Ile Leu Ala Gly Phe Leu Ala 
        275                 280                 285             


Glu Asp Trp His Ser Arg Arg Lys Arg Leu Arg His Arg Gly Arg Ala 
    290                 295                 300                 


Val Gln Arg Pro Leu Pro Pro Leu Pro Pro Leu Pro Leu Thr Arg Lys 
305                 310                 315                 320 


Ser Asn Gly Gly Gln Asp Gly Gly Arg Gln Asp Val His Ser Arg Gly 
                325                 330                 335     


Leu Cys Ser 
            


<210>  4212
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  4212

Met Asp Ser Leu Gln Lys Gln Asp Leu Arg Arg Pro Lys Ile His Gly 
1               5                   10                  15      


Ala Val Gln Ala Ser Pro Tyr Gln Pro Pro Thr Leu Ala Ser Leu Gln 
            20                  25                  30          


Arg Leu Leu Trp Val Arg Gln Ala Ala Thr Leu Asn His Ile Asp Glu 
        35                  40                  45              


Val Trp Pro Ser Leu Phe Leu Gly Asp Ala Tyr Ala Ala Arg Asp Lys 
    50                  55                  60                  


Ser Lys Leu Ile Gln Leu Gly Ile Thr His Val Val Asn Ala Ala Ala 
65                  70                  75                  80  


Gly Lys Phe Gln Val Asp Thr Gly Ala Lys Phe Tyr Arg Gly Met Ser 
                85                  90                  95      


Leu Glu Tyr Tyr Gly Ile Glu Ala Asp Asp Asn Pro Phe Phe Asp Leu 
            100                 105                 110         


Ser Val Tyr Phe Leu Pro Val Ala Arg Tyr Ile Arg Ala Ala Leu Ser 
        115                 120                 125             


Val Pro Gln Gly Arg Val Leu Val His Cys Ala Met Gly Val Ser Arg 
    130                 135                 140                 


Ser Ala Thr Leu Val Leu Ala Phe Leu Met Ile Cys Glu Asn Met Thr 
145                 150                 155                 160 


Leu Val Glu Ala Ile Gln Thr Val Gln Ala His Arg Asn Ile Cys Pro 
                165                 170                 175     


Asn Ser Gly Phe Leu Arg Gln Leu Gln Val Leu Asp Asn Arg Leu Gly 
            180                 185                 190         


Arg Glu Thr Gly Arg Phe 
        195             


<210>  4213
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  4213

Met Ser Thr Thr Thr Cys Gln Val Val Ala Phe Leu Leu Ser Ile Leu 
1               5                   10                  15      


Gly Leu Ala Gly Cys Ile Ala Ala Thr Gly Met Asp Met Trp Ser Thr 
            20                  25                  30          


Gln Asp Leu Tyr Asp Asn Pro Val Thr Ser Val Phe Gln Tyr Glu Gly 
        35                  40                  45              


Leu Trp Arg Ser Cys Val Arg Gln Ser Ser Gly Phe Thr Glu Cys Arg 
    50                  55                  60                  


Pro Tyr Phe Thr Ile Leu Gly Leu Pro Ala Met Leu Gln Ala Val Arg 
65                  70                  75                  80  


Ala Leu Met Ile Val Gly Ile Val Leu Gly Ala Ile Gly Leu Leu Val 
                85                  90                  95      


Ser Ile Phe Ala Leu Lys Cys Ile Arg Ile Gly Ser Met Glu Asp Ser 
            100                 105                 110         


Ala Lys Ala Asn Met Thr Leu Thr Ser Gly Ile Met Phe Ile Val Ser 
        115                 120                 125             


Gly Leu Cys Ala Ile Ala Gly Val Ser Val Phe Ala Asn Met Leu Val 
    130                 135                 140                 


Thr Asn Phe Trp Met Ser Thr Ala Asn Met Tyr Thr Gly Met Gly Gly 
145                 150                 155                 160 


Met Val Gln Thr Val Gln Thr Arg Tyr Thr Phe Gly Ala Ala Leu Phe 
                165                 170                 175     


Val Gly Trp Val Ala Gly Gly Leu Thr Leu Ile Gly Gly Val Met Met 
            180                 185                 190         


Cys Ile Ala Cys Arg Gly Leu Ala Pro Glu Glu Thr Asn Tyr Lys Ala 
        195                 200                 205             


Val Ser Tyr His Ala Ser Gly His Ser Val Ala Tyr Lys Pro Gly Gly 
    210                 215                 220                 


Phe Lys Ala Ser Thr Gly Phe Gly Ser Asn Thr Lys Asn Lys Lys Ile 
225                 230                 235                 240 


Tyr Asp Gly Gly Ala Arg Thr Glu Asp Glu Val Gln Ser Tyr Pro Ser 
                245                 250                 255     


Lys His Asp Tyr Val 
            260     


<210>  4214
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  4214

Met Asp Thr Leu Glu Glu Val Thr Trp Ala Asn Gly Ser Thr Ala Leu 
1               5                   10                  15      


Pro Pro Pro Leu Ala Pro Asn Ile Ser Val Pro His Arg Cys Leu Leu 
            20                  25                  30          


Leu Leu Tyr Glu Asp Ile Gly Thr Ser Arg Val Arg Tyr Trp Asp Leu 
        35                  40                  45              


Leu Leu Leu Ile Pro Asn Val Leu Phe Leu Ile Phe Leu Leu Trp Lys 
    50                  55                  60                  


Leu Pro Ser Ala Arg Ala Lys Ile Arg Ile Thr Ser Ser Pro Ile Phe 
65                  70                  75                  80  


Ile Thr Phe Tyr Ile Leu Val Phe Val Val Ala Leu Val Gly Ile Ala 
                85                  90                  95      


Arg Ala Val Val Ser Met Thr Val Ser Thr Ser Asn Ala Ala Thr Val 
            100                 105                 110         


Ala Asp Lys Ile Leu Trp Glu Ile Thr Arg Phe Phe Leu Leu Ala Ile 
        115                 120                 125             


Glu Leu Ser Val Ile Ile Leu Gly Leu Ala Phe Gly His Leu Glu Ser 
    130                 135                 140                 


Lys Ser Ser Ile Lys Arg Val Leu Ala Ile Thr Thr Val Leu Ser Leu 
145                 150                 155                 160 


Ala Tyr Ser Val Thr Gln Gly Thr Leu Glu Ile Leu Tyr Pro Asp Ala 
                165                 170                 175     


His Leu Ser Ala Glu Asp Phe Asn Ile Tyr Gly His Gly Gly Arg Gln 
            180                 185                 190         


Phe Trp Leu Val Ser Ser Cys Phe Phe Phe Leu Val Tyr Ser Leu Val 
        195                 200                 205             


Val Ile Leu Pro Lys Thr Pro Leu Lys Glu Arg Ile Ser Leu Pro Ser 
    210                 215                 220                 


Arg Arg Ser Phe Tyr Val Tyr Ala Gly Ile Leu Ala Leu Leu Asn Leu 
225                 230                 235                 240 


Leu Gln Gly Leu Gly Ser Val Leu Leu Cys Phe Asp Ile Ile Glu Gly 
                245                 250                 255     


Leu Cys Cys Val Asp Ala Thr Thr Phe Leu Tyr Phe Ser Phe Phe Ala 
            260                 265                 270         


Pro Leu Ile Tyr Val Ala Phe Leu Arg Gly Phe Phe Gly Ser Glu Pro 
        275                 280                 285             


Lys Ile Leu Phe Ser Tyr Lys Cys Gln Val Asp Glu Thr Glu Glu Pro 
    290                 295                 300                 


Asp Val His Leu Pro Gln Pro Tyr Ala Val Ala Arg Arg Glu Gly Leu 
305                 310                 315                 320 


Glu Ala Ala Gly Ala Ala Gly Ala Ser Ala Ala Ser Tyr Ser Ser Thr 
                325                 330                 335     


Gln Phe Asp Ser Ala Gly Gly Val Ala Tyr Leu Asp Asp Ile Ala Ser 
            340                 345                 350         


Met Pro Cys His Thr Gly Ser Ile Asn Ser Thr Asp Ser Glu Arg Trp 
        355                 360                 365             


Lys Ala Ile Asn Ala 
    370             


<210>  4215
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  4215

Met Leu Gly Gln Val Val Thr Leu Ile Leu Leu Leu Leu Leu Lys Val 
1               5                   10                  15      


Tyr Gln Gly Lys Gly Cys Gln Gly Ser Ala Asp His Val Val Ser Ile 
            20                  25                  30          


Ser Gly Val Pro Leu Gln Leu Gln Pro Asn Ser Ile Gln Thr Lys Val 
        35                  40                  45              


Asp Ser Ile Ala Trp Lys Lys Leu Leu Pro Ser Gln Asn Gly Phe His 
    50                  55                  60                  


His Ile Leu Lys Trp Glu Asn Gly Ser Leu Pro Ser Asn Thr Ser Asn 
65                  70                  75                  80  


Asp Arg Phe Ser Phe Ile Val Lys Asn Leu Ser Leu Leu Ile Lys Ala 
                85                  90                  95      


Ala Gln Gln Gln Asp Ser Gly Leu Tyr Cys Leu Glu Val Thr Ser Ile 
            100                 105                 110         


Ser Gly Lys Val Gln Thr Ala Thr Phe Gln Val Phe Val Phe Asp Lys 
        115                 120                 125             


Val Glu Lys Pro Arg Leu Gln Gly Gln Gly Lys Ile Leu Asp Arg Gly 
    130                 135                 140                 


Arg Cys Gln Val Ala Leu Ser Cys Leu Val Ser Arg Asp Gly Asn Val 
145                 150                 155                 160 


Ser Tyr Ala Trp Tyr Arg Gly Ser Lys Leu Ile Gln Thr Ala Gly Asn 
                165                 170                 175     


Leu Thr Tyr Leu Asp Glu Glu Val Asp Ile Asn Gly Thr His Thr Tyr 
            180                 185                 190         


Thr Cys Asn Val Ser Asn Pro Val Ser Trp Glu Ser His Thr Leu Asn 
        195                 200                 205             


Leu Thr Gln Asp Cys Gln Asn Ala His Gln Glu Phe Arg Phe Trp Pro 
    210                 215                 220                 


Phe Leu Val Ile Ile Val Ile Leu Ser Ala Leu Phe Leu Gly Thr Leu 
225                 230                 235                 240 


Ala Cys Phe Cys Val Trp Arg Arg Lys Arg Lys Glu Lys Gln Ser Glu 
                245                 250                 255     


Thr Ser Pro Lys Glu Phe Leu Thr Ile Tyr Glu Asp Val Lys Asp Leu 
            260                 265                 270         


Lys Thr Arg Arg Asn His Glu Gln Glu Gln Thr Phe Pro Gly Gly Gly 
        275                 280                 285             


Ser Thr Ile Tyr Ser Met Ile Gln Ser Gln Ser Ser Ala Pro Thr Ser 
    290                 295                 300                 


Gln Glu Pro Ala Tyr Thr Leu Tyr Ser Leu Ile Gln Pro Ser Arg Lys 
305                 310                 315                 320 


Ser Gly Ser Arg Lys Arg Asn His Ser Pro Ser Phe Asn Ser Thr Ile 
                325                 330                 335     


Tyr Glu Val Ile Gly Lys Ser Gln Pro Lys Ala Gln Asn Pro Ala Arg 
            340                 345                 350         


Leu Ser Arg Lys Glu Leu Glu Asn Phe Asp Val Tyr Ser 
        355                 360                 365 


<210>  4216
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  4216

Met Ser Gly Ile Ser Gly Cys Pro Phe Phe Leu Trp Gly Leu Leu Ala 
1               5                   10                  15      


Leu Leu Gly Leu Ala Leu Val Ile Ser Leu Ile Phe Asn Ile Ser His 
            20                  25                  30          


Tyr Val Glu Lys Gln Arg Gln Asp Lys Met Tyr Ser Tyr Ser Ser Asp 
        35                  40                  45              


His Thr Arg Val Asp Glu Tyr Tyr Ile Glu Asp Thr Pro Ile Tyr Gly 
    50                  55                  60                  


Asn Leu Asp Asp Met Ile Ser Glu Pro Met Asp Glu Asn Cys Tyr Glu 
65                  70                  75                  80  


Gln Met Lys Ala Arg Pro Glu Lys Ser Val Asn Lys Met Gln Glu Ala 
                85                  90                  95      


Thr Pro Ser Ala Gln Ala Thr Asn Glu Thr Gln Met Cys Tyr Ala Ser 
            100                 105                 110         


Leu Asp His Ser Val Lys Gly Lys Arg Arg Lys Pro Arg Lys Gln Asn 
        115                 120                 125             


Thr His Phe Ser Asp Lys Asp Gly Asp Glu Gln Leu His Ala Ile Asp 
    130                 135                 140                 


Ala Ser Val Ser Lys Thr Thr Leu Val Asp Ser Phe Ser Pro Glu Ser 
145                 150                 155                 160 


Gln Ala Val Glu Glu Asn Ile His Asp Asp Pro Ile Arg Leu Phe Gly 
                165                 170                 175     


Leu Ile Arg Ala Lys Arg Glu Pro Ile Asn 
            180                 185     


<210>  4217
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  4217

Met Ser Ala Asn Arg Arg Trp Trp Val Pro Pro Asp Asp Glu Asp Cys 
1               5                   10                  15      


Val Ser Glu Lys Leu Leu Arg Lys Thr Arg Glu Ser Pro Leu Val Pro 
            20                  25                  30          


Ile Gly Leu Gly Gly Cys Leu Val Val Ala Ala Tyr Arg Ile Tyr Arg 
        35                  40                  45              


Leu Arg Ser Arg Gly Ser Thr Lys Met Ser Ile His Leu Ile His Thr 
    50                  55                  60                  


Arg Val Ala Ala Gln Ala Cys Ala Val Gly Ala Ile Met Leu Gly Ala 
65                  70                  75                  80  


Val Tyr Thr Met Tyr Ser Asp Tyr Val Lys Arg Met Ala Gln Asp Ala 
                85                  90                  95      


Gly Glu Lys 
            


<210>  4218
<211>  1036
<212>  PRT
<213>  Homo sapiens

<400>  4218

Met Tyr Leu Val Ala Gly Asp Arg Gly Leu Ala Gly Cys Gly His Leu 
1               5                   10                  15      


Leu Val Ser Leu Leu Gly Leu Leu Leu Leu Leu Ala Arg Ser Gly Thr 
            20                  25                  30          


Arg Ala Leu Val Cys Leu Pro Cys Asp Glu Ser Lys Cys Glu Glu Pro 
        35                  40                  45              


Arg Asn Cys Pro Gly Ser Ile Val Gln Gly Val Cys Gly Cys Cys Tyr 
    50                  55                  60                  


Thr Cys Ala Ser Gln Arg Asn Glu Ser Cys Gly Gly Thr Phe Gly Ile 
65                  70                  75                  80  


Tyr Gly Thr Cys Asp Arg Gly Leu Arg Cys Val Ile Arg Pro Pro Leu 
                85                  90                  95      


Asn Gly Asp Ser Leu Thr Glu Tyr Glu Ala Gly Val Cys Glu Asp Glu 
            100                 105                 110         


Asn Trp Thr Asp Asp Gln Leu Leu Gly Phe Lys Pro Cys Asn Glu Asn 
        115                 120                 125             


Leu Ile Ala Gly Cys Asn Ile Ile Asn Gly Lys Cys Glu Cys Asn Thr 
    130                 135                 140                 


Ile Arg Thr Cys Ser Asn Pro Phe Glu Phe Pro Ser Gln Asp Met Cys 
145                 150                 155                 160 


Leu Ser Ala Leu Lys Arg Ile Glu Glu Glu Lys Pro Asp Cys Ser Lys 
                165                 170                 175     


Ala Arg Cys Glu Val Gln Phe Ser Pro Arg Cys Pro Glu Asp Ser Val 
            180                 185                 190         


Leu Ile Glu Gly Tyr Ala Pro Pro Gly Glu Cys Cys Pro Leu Pro Ser 
        195                 200                 205             


Arg Cys Val Cys Asn Pro Ala Gly Cys Leu Arg Lys Val Cys Gln Pro 
    210                 215                 220                 


Gly Asn Leu Asn Ile Leu Val Ser Lys Ala Ser Gly Lys Pro Gly Glu 
225                 230                 235                 240 


Cys Cys Asp Leu Tyr Glu Cys Lys Pro Val Phe Gly Val Asp Cys Arg 
                245                 250                 255     


Thr Val Glu Cys Pro Pro Val Gln Gln Thr Ala Cys Pro Pro Asp Ser 
            260                 265                 270         


Tyr Glu Thr Gln Val Arg Leu Thr Ala Asp Gly Cys Cys Thr Leu Pro 
        275                 280                 285             


Thr Arg Cys Glu Cys Leu Ser Gly Leu Cys Gly Phe Pro Val Cys Glu 
    290                 295                 300                 


Val Gly Ser Thr Pro Arg Ile Val Ser Arg Gly Asp Gly Thr Pro Gly 
305                 310                 315                 320 


Lys Cys Cys Asp Val Phe Glu Cys Val Asn Asp Thr Lys Pro Ala Cys 
                325                 330                 335     


Val Phe Asn Asn Val Glu Tyr Tyr Asp Gly Asp Met Phe Arg Met Asp 
            340                 345                 350         


Asn Cys Arg Phe Cys Arg Cys Gln Gly Gly Val Ala Ile Cys Phe Thr 
        355                 360                 365             


Ala Gln Cys Gly Glu Ile Asn Cys Glu Arg Tyr Tyr Val Pro Glu Gly 
    370                 375                 380                 


Glu Cys Cys Pro Val Cys Glu Asp Pro Val Tyr Pro Phe Asn Asn Pro 
385                 390                 395                 400 


Ala Gly Cys Tyr Ala Asn Gly Leu Ile Leu Ala His Gly Asp Arg Trp 
                405                 410                 415     


Arg Glu Asp Asp Cys Thr Phe Cys Gln Cys Val Asn Gly Glu Arg His 
            420                 425                 430         


Cys Val Ala Thr Val Cys Gly Gln Thr Cys Thr Asn Pro Val Lys Val 
        435                 440                 445             


Pro Gly Glu Cys Cys Pro Val Cys Glu Glu Pro Thr Ile Ile Thr Val 
    450                 455                 460                 


Asp Pro Pro Ala Cys Gly Glu Leu Ser Asn Cys Thr Leu Thr Gly Lys 
465                 470                 475                 480 


Asp Cys Ile Asn Gly Phe Lys Arg Asp His Asn Gly Cys Arg Thr Cys 
                485                 490                 495     


Gln Cys Ile Asn Thr Glu Glu Leu Cys Ser Glu Arg Lys Gln Gly Cys 
            500                 505                 510         


Thr Leu Asn Cys Pro Phe Gly Phe Leu Thr Asp Ala Gln Asn Cys Glu 
        515                 520                 525             


Ile Cys Glu Cys Arg Pro Arg Pro Lys Lys Cys Arg Pro Ile Ile Cys 
    530                 535                 540                 


Asp Lys Tyr Cys Pro Leu Gly Leu Leu Lys Asn Lys His Gly Cys Asp 
545                 550                 555                 560 


Ile Cys Arg Cys Lys Lys Cys Pro Glu Leu Ser Cys Ser Lys Ile Cys 
                565                 570                 575     


Pro Leu Gly Phe Gln Gln Asp Ser His Gly Cys Leu Ile Cys Lys Cys 
            580                 585                 590         


Arg Glu Ala Ser Ala Ser Ala Gly Pro Pro Ile Leu Ser Gly Thr Cys 
        595                 600                 605             


Leu Thr Val Asp Gly His His His Lys Asn Glu Glu Ser Trp His Asp 
    610                 615                 620                 


Gly Cys Arg Glu Cys Tyr Cys Leu Asn Gly Arg Glu Met Cys Ala Leu 
625                 630                 635                 640 


Ile Thr Cys Pro Val Pro Ala Cys Gly Asn Pro Thr Ile His Pro Gly 
                645                 650                 655     


Gln Cys Cys Pro Ser Cys Ala Asp Asp Phe Val Val Gln Lys Pro Glu 
            660                 665                 670         


Leu Ser Thr Pro Ser Ile Cys His Ala Pro Gly Gly Glu Tyr Phe Val 
        675                 680                 685             


Glu Gly Glu Thr Trp Asn Ile Asp Ser Cys Thr Gln Cys Thr Cys His 
    690                 695                 700                 


Ser Gly Arg Val Leu Cys Glu Thr Glu Val Cys Pro Pro Leu Leu Cys 
705                 710                 715                 720 


Gln Asn Pro Ser Arg Thr Gln Asp Ser Cys Cys Pro Gln Cys Thr Asp 
                725                 730                 735     


Gln Pro Phe Arg Pro Ser Leu Ser Arg Asn Asn Ser Val Pro Asn Tyr 
            740                 745                 750         


Cys Lys Asn Asp Glu Gly Asp Ile Phe Leu Ala Ala Glu Ser Trp Lys 
        755                 760                 765             


Pro Asp Val Cys Thr Ser Cys Ile Cys Ile Asp Ser Val Ile Ser Cys 
    770                 775                 780                 


Phe Ser Glu Ser Cys Pro Ser Val Ser Cys Glu Arg Pro Val Leu Arg 
785                 790                 795                 800 


Lys Gly Gln Cys Cys Pro Tyr Cys Ile Glu Asp Thr Ile Pro Lys Lys 
                805                 810                 815     


Val Val Cys His Phe Ser Gly Lys Ala Tyr Ala Asp Glu Glu Arg Trp 
            820                 825                 830         


Asp Leu Asp Ser Cys Thr His Cys Tyr Cys Leu Gln Gly Gln Thr Leu 
        835                 840                 845             


Cys Ser Thr Val Ser Cys Pro Pro Leu Pro Cys Val Glu Pro Ile Asn 
    850                 855                 860                 


Val Glu Gly Ser Cys Cys Pro Met Cys Pro Glu Met Tyr Val Pro Glu 
865                 870                 875                 880 


Pro Thr Asn Ile Pro Ile Glu Lys Thr Asn His Arg Gly Glu Val Asp 
                885                 890                 895     


Leu Glu Val Pro Leu Trp Pro Thr Pro Ser Glu Asn Asp Ile Val His 
            900                 905                 910         


Leu Pro Arg Asp Met Gly His Leu Gln Val Asp Tyr Arg Asp Asn Arg 
        915                 920                 925             


Leu His Pro Ser Glu Asp Ser Ser Leu Asp Ser Ile Ala Ser Val Val 
    930                 935                 940                 


Val Pro Ile Ile Ile Cys Leu Ser Ile Ile Ile Ala Phe Leu Phe Ile 
945                 950                 955                 960 


Asn Gln Lys Lys Gln Trp Ile Pro Leu Leu Cys Trp Tyr Arg Thr Pro 
                965                 970                 975     


Thr Lys Pro Ser Ser Leu Asn Asn Gln Leu Val Ser Val Asp Cys Lys 
            980                 985                 990         


Lys Gly Thr Arg Val Gln Val Asp  Ser Ser Gln Arg Met  Leu Arg Ile 
        995                 1000                 1005             


Ala Glu  Pro Asp Ala Arg Phe  Ser Gly Phe Tyr Ser  Met Gln Lys 
    1010                 1015                 1020             


Gln Asn  His Leu Gln Ala Asp  Asn Phe Tyr Gln Thr  Val 
    1025                 1030                 1035     


<210>  4219
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  4219

Met Asn Met Pro Gln Ser Leu Gly Asn Gln Pro Leu Pro Pro Glu Pro 
1               5                   10                  15      


Pro Ser Leu Gly Thr Pro Ala Glu Gly Pro Gly Thr Thr Ser Pro Pro 
            20                  25                  30          


Glu His Cys Trp Pro Val Arg Pro Thr Leu Arg Asn Glu Leu Asp Thr 
        35                  40                  45              


Phe Ser Val His Phe Tyr Ile Phe Phe Gly Pro Ser Val Ala Leu Pro 
    50                  55                  60                  


Pro Glu Arg Pro Ala Val Phe Ala Met Arg Leu Leu Pro Val Leu Asp 
65                  70                  75                  80  


Ser Gly Gly Val Leu Ser Leu Glu Leu Gln Leu Asn Ala Ser Ser Val 
                85                  90                  95      


Arg Gln Glu Asn Val Thr Val Phe Gly Cys Leu Thr His Glu Val Pro 
            100                 105                 110         


Leu Ser Leu Gly Asp Ala Ala Val Thr Cys Ser Lys Glu Ser Leu Ala 
        115                 120                 125             


Gly Phe Leu Leu Ser Val Ser Ala Thr Thr Arg Val Ala Arg Leu Arg 
    130                 135                 140                 


Ile Pro Phe Pro Gln Thr Gly Thr Trp Phe Leu Ala Leu Arg Ser Leu 
145                 150                 155                 160 


Cys Gly Val Gly Pro Arg Phe Val Arg Cys Arg Asn Ala Thr Ala Glu 
                165                 170                 175     


Val Arg Met Arg Thr Phe Leu Ser Pro Cys Val Asp Asp Cys Gly Pro 
            180                 185                 190         


Tyr Gly Gln Cys Lys Leu Leu Arg Thr His Asn Tyr Leu Tyr Ala Ala 
        195                 200                 205             


Cys Glu Cys Lys Ala Gly Trp Arg Gly Trp Gly Cys Thr Asp Ser Ala 
    210                 215                 220                 


Asp Ala Leu Thr Tyr Gly Phe Gln Leu Leu Ser Thr Leu Leu Leu Cys 
225                 230                 235                 240 


Leu Ser Asn Leu Met Phe Leu Pro Pro Val Val Leu Ala Ile Arg Ser 
                245                 250                 255     


Arg Tyr Val Leu Glu Ala Ala Val Tyr Thr Phe Thr Met Phe Phe Ser 
            260                 265                 270         


Thr Val Cys Gly Gly Val Cys Ile Leu Ser Leu Gly Ala Cys Ala Trp 
        275                 280                 285             


Trp Trp Val Thr Val Cys Ile Ser Thr Thr Phe Ser Glu Gly Leu Gly 
    290                 295                 300                 


Met Ser Val Pro Ser Leu Cys Leu Leu Gln Thr Glu Thr Ala Val Leu 
305                 310                 315                 320 


Pro Lys Leu Ser Cys Ile Asp Asn Gly His Phe Cys Lys Thr His Trp 
                325                 330                 335     


Ser Lys 
        


<210>  4220
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  4220

Met Thr Ala Gln Gly Gly Leu Val Ala Asn Arg Gly Arg Arg Phe Lys 
1               5                   10                  15      


Trp Ala Ile Glu Leu Ser Gly Pro Gly Gly Gly Ser Arg Gly Arg Ser 
            20                  25                  30          


Asp Arg Gly Ser Gly Gln Gly Asp Ser Leu Tyr Pro Val Gly Tyr Leu 
        35                  40                  45              


Asp Lys Gln Val Pro Asp Thr Ser Val Gln Glu Thr Asp Arg Ile Leu 
    50                  55                  60                  


Val Glu Lys Arg Cys Trp Asp Ile Ala Leu Gly Pro Leu Lys Gln Ile 
65                  70                  75                  80  


Pro Met Asn Leu Phe Ile Met Tyr Met Ala Gly Asn Thr Ile Ser Ile 
                85                  90                  95      


Phe Pro Thr Met Met Val Cys Met Met Ala Trp Arg Pro Ile Gln Ala 
            100                 105                 110         


Leu Met Ala Ile Ser Ala Thr Phe Lys Met Leu Glu Ser Ser Ser Gln 
        115                 120                 125             


Lys Phe Leu Gln Gly Leu Val Tyr Leu Ile Gly Asn Leu Met Gly Leu 
    130                 135                 140                 


Ala Leu Ala Val Tyr Lys Cys Gln Ser Met Gly Leu Leu Pro Thr His 
145                 150                 155                 160 


Ala Ser Asp Trp Leu Ala Phe Ile Glu Pro Pro Glu Arg Met Glu Phe 
                165                 170                 175     


Ser Gly Gly Gly Leu Leu Leu 
            180             


<210>  4221
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  4221

Met Lys Leu Leu Ser Leu Val Ala Val Val Gly Cys Leu Leu Val Pro 
1               5                   10                  15      


Pro Ala Glu Ala Asn Lys Ser Ser Glu Asp Ile Arg Cys Lys Cys Ile 
            20                  25                  30          


Cys Pro Pro Tyr Arg Asn Ile Ser Gly His Ile Tyr Asn Gln Asn Val 
        35                  40                  45              


Ser Gln Lys Asp Cys Asn Cys Leu His Val Val Glu Pro Met Pro Val 
    50                  55                  60                  


Pro Gly His Asp Val Glu Ala Tyr Cys Leu Leu Cys Glu Cys Arg Tyr 
65                  70                  75                  80  


Glu Glu Arg Ser Thr Thr Thr Ile Lys Val Ile Ile Val Ile Tyr Leu 
                85                  90                  95      


Ser Val Val Gly Ala Leu Leu Leu Tyr Met Ala Phe Leu Met Leu Val 
            100                 105                 110         


Asp Pro Leu Ile Arg Lys Pro Asp Ala Tyr Thr Glu Gln Leu His Asn 
        115                 120                 125             


Glu Glu Glu Asn Glu Asp Ala Arg Ser Met Ala Ala Ala Ala Ala Ser 
    130                 135                 140                 


Leu Gly Gly Pro Arg Ala Asn Thr Val Leu Glu Arg Val Glu Gly Ala 
145                 150                 155                 160 


Gln Gln Arg Trp Lys Leu Gln Val Gln Glu Gln Arg Lys Thr Val Phe 
                165                 170                 175     


Asp Arg His Lys Met Leu Ser 
            180             


<210>  4222
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  4222

Met Gln Asp Thr Gly Ser Val Val Pro Leu His Trp Phe Gly Phe Gly 
1               5                   10                  15      


Tyr Ala Ala Leu Val Ala Ser Gly Gly Ile Ile Gly Tyr Val Lys Ala 
            20                  25                  30          


Gly Ser Val Pro Ser Leu Ala Ala Gly Leu Leu Phe Gly Ser Leu Ala 
        35                  40                  45              


Gly Leu Gly Ala Tyr Gln Leu Ser Gln Asp Pro Arg Asn Val Trp Val 
    50                  55                  60                  


Phe Leu Ala Thr Ser Gly Thr Leu Ala Gly Ile Met Gly Met Arg Phe 
65                  70                  75                  80  


Tyr His Ser Gly Lys Phe Met Pro Ala Gly Leu Ile Ala Gly Ala Ser 
                85                  90                  95      


Leu Leu Met Val Ala Lys Val Gly Val Ser Met Phe Asn Arg Pro His 
            100                 105                 110         


<210>  4223
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  4223

Met Leu Gln Thr Ser Asn Tyr Ser Leu Val Leu Ser Leu Gln Phe Leu 
1               5                   10                  15      


Leu Leu Ser Tyr Asp Leu Phe Val Asn Ser Phe Ser Glu Leu Leu Gln 
            20                  25                  30          


Lys Thr Pro Val Ile Gln Leu Val Leu Phe Ile Ile Gln Asp Ile Ala 
        35                  40                  45              


Val Leu Phe Asn Ile Ile Ile Ile Phe Leu Met Phe Phe Asn Thr Phe 
    50                  55                  60                  


Val Phe Gln Ala Gly Leu Val Asn Leu Leu Phe His Lys Phe Lys Gly 
65                  70                  75                  80  


Thr Ile Ile Leu Thr Ala Val Tyr Phe Ala Leu Ser Ile Ser Leu His 
                85                  90                  95      


Val Trp Val Met Asn Leu Arg Trp Lys Asn Ser Asn Ser Phe Ile Trp 
            100                 105                 110         


Thr Asp Gly Leu Gln Met Leu Phe Val Phe Gln Arg Leu Ala Ala Val 
        115                 120                 125             


Leu Tyr Cys Tyr Phe Tyr Lys Arg Thr Ala Val Arg Leu Gly Asp Pro 
    130                 135                 140                 


His Phe Tyr Gln Asp Ser Leu Trp Leu Arg Lys Glu Phe Met Gln Val 
145                 150                 155                 160 


Arg Arg 
        


<210>  4224
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  4224

Met Asn Val Gly Val Ala His Ser Glu Val Asn Pro Asn Thr Arg Val 
1               5                   10                  15      


Met Asn Ser Arg Gly Met Trp Leu Thr Tyr Ala Leu Gly Val Gly Leu 
            20                  25                  30          


Leu His Ile Val Leu Leu Ser Ile Pro Phe Phe Ser Val Pro Val Ala 
        35                  40                  45              


Trp Thr Leu Thr Asn Ile Ile His Asn Leu Gly Met Tyr Val Phe Leu 
    50                  55                  60                  


His Ala Val Lys Gly Thr Pro Phe Glu Thr Pro Asp Gln Gly Lys Ala 
65                  70                  75                  80  


Arg Leu Leu Thr His Trp Glu Gln Leu Asp Tyr Gly Val Gln Phe Thr 
                85                  90                  95      


Ser Ser Arg Lys Phe Phe Thr Ile Ser Pro Ile Ile Leu Tyr Phe Leu 
            100                 105                 110         


Ala Ser Phe Tyr Thr Lys Tyr Asp Pro Thr His Phe Ile Leu Asn Thr 
        115                 120                 125             


Ala Ser Leu Leu Ser Val Leu Ile Pro Lys Met Pro Gln Leu His Gly 
    130                 135                 140                 


Val Arg Ile Phe Gly Ile Asn Lys Tyr 
145                 150             


<210>  4225
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  4225

Met Thr Ala Pro Val Pro Ala Pro Arg Ile Leu Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Thr Pro Pro Pro Gly Ala Arg Gly Glu Val Cys Met 
            20                  25                  30          


Ala Ser Arg Gly Leu Ser Leu Phe Pro Glu Ser Cys Pro Asp Phe Cys 
        35                  40                  45              


Cys Gly Thr Cys Asp Asp Gln Tyr Cys Cys Ser Asp Val Leu Lys Lys 
    50                  55                  60                  


Phe Val Trp Ser Glu Glu Arg Cys Ala Val Pro Glu Ala Ser Val Pro 
65                  70                  75                  80  


Ala Ser Val Glu Pro Val Glu Gln Leu Gly Ser Ala Leu Arg Phe Arg 
                85                  90                  95      


Pro Gly Tyr Asn Asp Pro Met Ser Gly Phe Gly Ala Thr Leu Ala Val 
            100                 105                 110         


Gly Leu Thr Ile Phe Val Leu Ser Val Val Thr Ile Ile Ile Cys Phe 
        115                 120                 125             


Thr Cys Ser Cys Cys Cys Leu Tyr Lys Thr Cys Arg Arg Pro Arg Pro 
    130                 135                 140                 


Val Val Thr Thr Thr Thr Ser Thr Thr Val Val His Ala Pro Tyr Pro 
145                 150                 155                 160 


Gln Pro Pro Ser Val Pro Pro Ser Tyr Pro Gly Pro Ser Tyr Gln Gly 
                165                 170                 175     


Tyr His Thr Met Pro Pro Gln Pro Gly Met Pro Ala Ala Pro Tyr Pro 
            180                 185                 190         


Met Gln Tyr Pro Pro Pro Tyr Pro Ala Gln Pro Met Gly Pro Pro Ala 
        195                 200                 205             


Tyr His Glu Thr Leu Ala Gly Gly Ala Ala Ala Pro Tyr Pro Ala Ser 
    210                 215                 220                 


Gln Pro Pro Tyr Asn Pro Ala Tyr Met Asp Ala Pro Lys Ala Ala Leu 
225                 230                 235                 240 


<210>  4226
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  4226

Met Leu Arg Phe Ile Gln Lys Phe Ser Gln Ala Ser Ser Lys Ile Leu 
1               5                   10                  15      


Lys Tyr Ser Phe Pro Val Gly Leu Arg Thr Ser Arg Thr Asp Ile Leu 
            20                  25                  30          


Ser Leu Lys Met Ser Leu Gln Gln Asn Phe Ser Pro Cys Pro Arg Pro 
        35                  40                  45              


Trp Leu Ser Ser Ser Phe Pro Ala Tyr Met Ser Lys Thr Gln Cys Tyr 
    50                  55                  60                  


His Thr Ser Pro Cys Ser Phe Lys Lys Gln Gln Lys Gln Ala Leu Leu 
65                  70                  75                  80  


Ala Arg Pro Ser Ser Thr Ile Thr Tyr Leu Thr Asp Ser Pro Lys Pro 
                85                  90                  95      


Ala Leu Cys Val Thr Leu Ala Gly Leu Ile Pro Phe Val Ala Pro Pro 
            100                 105                 110         


Leu Val Met Leu Met Thr Lys Thr Tyr Ile Pro Ile Leu Ala Phe Thr 
        115                 120                 125             


Gln Met Ala Tyr Gly Ala Ser Phe Leu Ser Phe Leu Gly Gly Ile Arg 
    130                 135                 140                 


Trp Gly Phe Ala Leu Pro Glu Gly Ser Pro Ala Lys Pro Asp Tyr Leu 
145                 150                 155                 160 


Asn Leu Ala Ser Ser Ala Ala Pro Leu Phe Phe Ser Trp Phe Ala Phe 
                165                 170                 175     


Leu Ile Ser Glu Arg Leu Ser Glu Ala Ile Val Thr Val Ile Met Gly 
            180                 185                 190         


Met Gly Val Ala Phe His Leu Glu Leu Phe Leu Leu Pro His Tyr Pro 
        195                 200                 205             


Asn Trp Phe Lys Ala Leu Arg Ile Val Val Thr Leu Leu Ala Thr Phe 
    210                 215                 220                 


Ser Phe Ile Ile Thr Leu Val Val Lys Ser Ser Phe Pro Glu Lys Gly 
225                 230                 235                 240 


His Lys Arg Pro Gly Gln Val 
                245         


<210>  4227
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  4227

Met Thr Asn Gln Glu Ser Ala Val His Val Lys Met Met Pro Glu Phe 
1               5                   10                  15      


Gln Lys Ser Ser Val Arg Ile Lys Asn Pro Thr Arg Val Glu Glu Ile 
            20                  25                  30          


Ile Cys Gly Leu Ile Lys Gly Gly Ala Ala Lys Leu Gln Ile Ile Thr 
        35                  40                  45              


Asp Phe Asp Met Thr Leu Ser Arg Phe Ser Tyr Lys Gly Lys Arg Cys 
    50                  55                  60                  


Pro Thr Cys His Asn Ile Ile Asp Asn Cys Lys Leu Val Thr Asp Glu 
65                  70                  75                  80  


Cys Arg Lys Lys Leu Leu Gln Leu Lys Glu Lys Tyr Tyr Ala Ile Glu 
                85                  90                  95      


Val Asp Pro Val Leu Thr Val Glu Glu Lys Tyr Pro Tyr Met Val Glu 
            100                 105                 110         


Trp Tyr Thr Lys Ser His Gly Leu Leu Val Gln Gln Ala Leu Pro Lys 
        115                 120                 125             


Ala Lys Leu Lys Glu Ile Val Ala Glu Ser Asp Val Met Leu Lys Glu 
    130                 135                 140                 


Gly Tyr Glu Asn Phe Phe Asp Lys Leu Gln Gln His Ser Ile Pro Val 
145                 150                 155                 160 


Phe Ile Phe Ser Ala Gly Ile Gly Asp Val Leu Glu Glu Val Ile Arg 
                165                 170                 175     


Gln Ala Gly Val Tyr His Pro Asn Val Lys Val Val Ser Asn Phe Met 
            180                 185                 190         


Asp Phe Asp Glu Thr Gly Val Leu Lys Gly Phe Lys Gly Glu Leu Ile 
        195                 200                 205             


His Val Phe Asn Lys His Asp Gly Ala Leu Arg Asn Thr Glu Tyr Phe 
    210                 215                 220                 


Asn Gln Leu Lys Asp Asn Ser Asn Ile Ile Leu Leu Gly Asp Ser Gln 
225                 230                 235                 240 


Gly Asp Leu Arg Met Ala Asp Gly Val Ala Asn Val Glu His Ile Leu 
                245                 250                 255     


Lys Ile Gly Tyr Leu Asn Asp Arg Val Asp Glu Leu Leu Glu Lys Tyr 
            260                 265                 270         


Met Asp Ser Tyr Asp Ile Val Leu Val Gln Asp Glu Ser Leu Glu Val 
        275                 280                 285             


Ala Asn Ser Ile Leu Gln Lys Ile Leu 
    290                 295         


<210>  4228
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  4228

Met Thr Glu Asp Ser Gln Arg Asn Phe Arg Ser Val Tyr Tyr Glu Lys 
1               5                   10                  15      


Val Gly Phe Arg Gly Val Glu Glu Lys Lys Ser Leu Glu Ile Leu Leu 
            20                  25                  30          


Lys Asp Asp Arg Leu Asp Thr Glu Lys Leu Cys Thr Phe Ser Gln Arg 
        35                  40                  45              


Phe Pro Leu Pro Ser Met Tyr Arg Ala Leu Val Trp Lys Val Leu Leu 
    50                  55                  60                  


Gly Ile Leu Pro Pro His His Glu Ser His Ala Lys Val Met Met Tyr 
65                  70                  75                  80  


Arg Lys Glu Gln Tyr Leu Asp Val Leu His Ala Leu Lys Val Val Arg 
                85                  90                  95      


Phe Val Ser Asp Ala Thr Pro Gln Ala Glu Val Tyr Leu Arg Met Tyr 
            100                 105                 110         


Gln Leu Glu Ser Gly Lys Leu Pro Arg Ser Pro Ser Phe Pro Leu Glu 
        115                 120                 125             


Pro Asp Asp Glu Val Phe Leu Ala Ile Ala Lys Ala Met Glu Glu Met 
    130                 135                 140                 


Val Glu Asp Ser Val Asp Cys Tyr Trp Ile Thr Arg Arg Phe Val Asn 
145                 150                 155                 160 


Gln Leu Asn Thr Lys Tyr Arg Asp Ser Leu Pro Gln Leu Pro Lys Ala 
                165                 170                 175     


Phe Glu Gln Tyr Leu Asn Leu Glu Asp Gly Arg Leu Leu Thr His Leu 
            180                 185                 190         


Arg Met Cys Ser Ala Ala Pro Lys Leu Pro Tyr Asp Leu Trp Phe Lys 
        195                 200                 205             


Arg Cys Phe Ala Gly Cys Leu Pro Glu Ser Ser Leu Gln Arg Val Trp 
    210                 215                 220                 


Asp Lys Val Val Ser Gly Ser Cys Lys Ile Leu Val Phe Val Ala Val 
225                 230                 235                 240 


Glu Ile Leu Leu Thr Phe Lys Ile Lys Val Met Ala Leu Asn Ser Ala 
                245                 250                 255     


Glu Lys Ile Thr Lys Phe Leu Glu Asn Ile Pro Gln Asp Ser Ser Asp 
            260                 265                 270         


Ala Ile Val Ser Lys Ala Ile Asp Leu Trp His Lys His Cys Gly Thr 
        275                 280                 285             


Pro Val His Ser Ser 
    290             


<210>  4229
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  4229

Met Ser Glu Pro Gln Pro Arg Gly Ala Glu Arg Asp Leu Tyr Arg Asp 
1               5                   10                  15      


Thr Trp Val Arg Tyr Leu Gly Tyr Ala Asn Glu Val Gly Glu Ala Phe 
            20                  25                  30          


Arg Ser Leu Val Pro Ala Ala Val Val Trp Leu Ser Tyr Gly Val Ala 
        35                  40                  45              


Ser Ser Tyr Val Leu Ala Asp Ala Ile Asp Lys Gly Lys Lys Ala Gly 
    50                  55                  60                  


Glu Val Pro Ser Pro Glu Ala Gly Arg Ser Ala Arg Val Thr Val Ala 
65                  70                  75                  80  


Val Val Asp Thr Phe Val Trp Gln Ala Leu Ala Ser Val Ala Ile Pro 
                85                  90                  95      


Gly Phe Thr Ile Asn Arg Val Cys Ala Ala Ser Leu Tyr Val Leu Gly 
            100                 105                 110         


Thr Ala Thr Arg Trp Pro Leu Ala Val Arg Lys Trp Thr Thr Thr Ala 
        115                 120                 125             


Leu Gly Leu Leu Thr Ile Pro Ile Ile Ile His Pro Ile Asp Arg Ser 
    130                 135                 140                 


Val Asp Phe Leu Leu Asp Ser Ser Leu Arg Lys Leu Tyr Pro Thr Val 
145                 150                 155                 160 


Gly Lys Pro Ser Ser Ser 
                165     


<210>  4230
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  4230

Met Leu Leu Leu Tyr Leu Gly Ile Glu Val Ile Arg Leu Phe Phe Gly 
1               5                   10                  15      


Thr Lys Gly Asn Leu Cys Gln Arg Lys Met Pro Leu Ser Ile Ser Val 
            20                  25                  30          


Ala Leu Thr Phe Pro Ser Ala Met Met Ala Ser Tyr Tyr Leu Leu Leu 
        35                  40                  45              


Gln Thr Tyr Val Leu Arg Leu Glu Ala Ile Met Asn Gly Ile Leu Leu 
    50                  55                  60                  


Phe Phe Cys Gly Ser Glu Leu Leu Leu Glu Val Leu Thr Leu Ala Ala 
65                  70                  75                  80  


Phe Ser Ser Met Asp Arg Ile 
                85          


<210>  4231
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  4231

Met Gln Asp Glu Asp Gly Tyr Ile Thr Leu Asn Ile Lys Thr Arg Lys 
1               5                   10                  15      


Pro Ala Leu Ile Ser Val Gly Ser Ala Ser Ser Ser Trp Trp Arg Val 
            20                  25                  30          


Met Ala Leu Ile Leu Leu Ile Leu Cys Val Gly Met Val Val Gly Leu 
        35                  40                  45              


Val Ala Leu Gly Ile Trp Ser Val Met Gln Arg Asn Tyr Leu Gln Gly 
    50                  55                  60                  


Glu Asn Glu Asn Arg Thr Gly Thr Leu Gln Gln Leu Ala Lys Arg Phe 
65                  70                  75                  80  


Cys Gln Tyr Val Val Lys Gln Ser Glu Leu Lys Gly Thr Phe Lys Gly 
                85                  90                  95      


His Lys Cys Ser Pro Cys Asp Thr Asn Trp Arg Tyr Tyr Gly Asp Ser 
            100                 105                 110         


Cys Tyr Gly Phe Phe Arg His Asn Leu Thr Trp Glu Glu Ser Lys Gln 
        115                 120                 125             


Tyr Cys Thr Asp Met Asn Ala Thr Leu Leu Lys Ile Asp Asn Arg Asn 
    130                 135                 140                 


Ile Val Glu Tyr Ile Lys Ala Arg Thr His Leu Ile Arg Trp Val Gly 
145                 150                 155                 160 


Leu Ser Arg Gln Lys Ser Asn Glu Val Trp Lys Trp Glu Asp Gly Ser 
                165                 170                 175     


Val Ile Ser Glu Asn Met Phe Glu Phe Leu Glu Asp Gly Lys Gly Asn 
            180                 185                 190         


Met Asn Cys Ala Tyr Phe His Asn Gly Lys Met His Pro Thr Phe Cys 
        195                 200                 205             


Glu Asn Lys His Tyr Leu Met Cys Glu Arg Lys Ala Gly Met Thr Lys 
    210                 215                 220                 


Val Asp Gln Leu Pro 
225                 


<210>  4232
<211>  280
<212>  PRT
<213>  Homo sapiens

<400>  4232

Met Gln Ala Lys Tyr Ser Ser Thr Arg Asp Met Leu Asp Asp Asp Gly 
1               5                   10                  15      


Asp Thr Thr Met Ser Leu His Ser Gln Gly Ser Ala Thr Thr Arg His 
            20                  25                  30          


Pro Glu Pro Arg Arg Thr Glu His Arg Ala Pro Ser Ser Thr Trp Arg 
        35                  40                  45              


Pro Val Ala Leu Thr Leu Leu Thr Leu Cys Leu Val Leu Leu Ile Gly 
    50                  55                  60                  


Leu Ala Ala Leu Gly Leu Leu Phe Phe Gln Tyr Tyr Gln Leu Ser Asn 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Ile Ser Gln Met Glu Glu Arg Leu Gly Asn Thr 
                85                  90                  95      


Ser Gln Glu Leu Gln Ser Leu Gln Val Gln Asn Ile Lys Leu Ala Gly 
            100                 105                 110         


Ser Leu Gln His Val Ala Glu Lys Leu Cys Arg Glu Leu Tyr Asn Lys 
        115                 120                 125             


Ala Gly Ala His Arg Cys Ser Pro Cys Thr Glu Gln Trp Lys Trp His 
    130                 135                 140                 


Gly Asp Asn Cys Tyr Gln Phe Tyr Lys Asp Ser Lys Ser Trp Glu Asp 
145                 150                 155                 160 


Cys Lys Tyr Phe Cys Leu Ser Glu Asn Ser Thr Met Leu Lys Ile Asn 
                165                 170                 175     


Lys Gln Glu Asp Leu Glu Phe Ala Ala Ser Gln Ser Tyr Ser Glu Phe 
            180                 185                 190         


Phe Tyr Ser Tyr Trp Thr Gly Leu Leu Arg Pro Asp Ser Gly Lys Ala 
        195                 200                 205             


Trp Leu Trp Met Asp Gly Thr Pro Phe Thr Ser Glu Leu Phe His Ile 
    210                 215                 220                 


Ile Ile Asp Val Thr Ser Pro Arg Ser Arg Asp Cys Val Ala Ile Leu 
225                 230                 235                 240 


Asn Gly Met Ile Phe Ser Lys Asp Cys Lys Glu Leu Lys Arg Cys Val 
                245                 250                 255     


Cys Glu Arg Arg Ala Gly Met Val Lys Pro Glu Ser Leu His Val Pro 
            260                 265                 270         


Pro Glu Thr Leu Gly Glu Gly Asp 
        275                 280 


<210>  4233
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  4233

Met Ala Ala Gln Lys Asp Leu Trp Asp Ala Ile Val Ile Gly Ala Gly 
1               5                   10                  15      


Ile Gln Gly Cys Phe Thr Ala Tyr His Leu Ala Lys His Arg Lys Arg 
            20                  25                  30          


Ile Leu Leu Leu Glu Gln Phe Phe Leu Pro His Ser Arg Gly Ser Ser 
        35                  40                  45              


His Gly Gln Ser Arg Ile Ile Arg Lys Ala Tyr Leu Glu Asp Phe Tyr 
    50                  55                  60                  


Thr Arg Met Met His Glu Cys Tyr Gln Ile Trp Ala Gln Leu Glu His 
65                  70                  75                  80  


Glu Ala Gly Thr Gln Leu His Arg Gln Thr Gly Leu Leu Leu Leu Gly 
                85                  90                  95      


Met Lys Glu Asn Gln Glu Leu Lys Thr Ile Gln Ala Asn Leu Ser Arg 
            100                 105                 110         


Gln Arg Val Glu His Gln Cys Leu Ser Ser Glu Glu Leu Lys Gln Arg 
        115                 120                 125             


Phe Pro Asn Ile Arg Leu Pro Arg Gly Glu Val Gly Leu Leu Asp Asn 
    130                 135                 140                 


Ser Gly Gly Val Ile Tyr Ala Tyr Lys Ala Leu Arg Ala Leu Gln Asp 
145                 150                 155                 160 


Ala Ile Arg Gln Leu Gly Gly Ile Val Arg Asp Gly Glu Lys Val Val 
                165                 170                 175     


Glu Ile Asn Pro Gly Leu Leu Val Thr Val Lys Thr Thr Ser Arg Ser 
            180                 185                 190         


Tyr Gln Ala Lys Ser Leu Val Ile Thr Ala Gly Pro Trp Thr Asn Gln 
        195                 200                 205             


Leu Leu Arg Pro Leu Gly Ile Glu Met Pro Leu Gln Thr Leu Arg Ile 
    210                 215                 220                 


Asn Val Cys Tyr Trp Arg Glu Met Val Pro Gly Ser Tyr Gly Val Ser 
225                 230                 235                 240 


Gln Ala Phe Pro Cys Phe Leu Trp Leu Gly Leu Cys Pro His His Ile 
                245                 250                 255     


Tyr Gly Leu Pro Thr Gly Glu Tyr Pro Gly Leu Met Lys Val Ser Tyr 
            260                 265                 270         


His His Gly Asn His Ala Asp Pro Glu Glu Arg Asp Cys Pro Thr Ala 
        275                 280                 285             


Arg Thr Asp Ile Gly Asp Val Gln Ile Leu Ser Ser Phe Val Arg Asp 
    290                 295                 300                 


His Leu Pro Asp Leu Lys Pro Glu Pro Ala Val Ile Glu Ser Cys Met 
305                 310                 315                 320 


Tyr Thr Asn Thr Pro Asp Glu Gln Phe Ile Leu Asp Arg His Pro Lys 
                325                 330                 335     


Tyr Asp Asn Ile Val Ile Gly Ala Gly Phe Ser Gly His Gly Phe Lys 
            340                 345                 350         


Leu Ala Pro Val Val Gly Lys Ile Leu Tyr Glu Leu Ser Met Lys Leu 
        355                 360                 365             


Thr Pro Ser Tyr Asp Leu Ala Pro Phe Arg Ile Ser Arg Phe Pro Ser 
    370                 375                 380                 


Leu Gly Lys Ala His Leu 
385                 390 


<210>  4234
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  4234

Met Gly Val Cys Gly Tyr Leu Phe Leu Pro Trp Lys Cys Leu Val Val 
1               5                   10                  15      


Val Ser Leu Arg Leu Leu Phe Leu Val Pro Thr Gly Val Pro Val Arg 
            20                  25                  30          


Ser Gly Asp Ala Thr Phe Pro Lys Ala Met Asp Asn Val Thr Val Arg 
        35                  40                  45              


Gln Gly Glu Ser Ala Thr Leu Arg Cys Thr Ile Asp Asn Arg Val Thr 
    50                  55                  60                  


Arg Val Ala Trp Leu Asn Arg Ser Thr Ile Leu Tyr Ala Gly Asn Asp 
65                  70                  75                  80  


Lys Trp Cys Leu Asp Pro Arg Val Val Leu Leu Ser Asn Thr Gln Thr 
                85                  90                  95      


Gln Tyr Ser Ile Glu Ile Gln Asn Val Asp Val Tyr Asp Glu Gly Pro 
            100                 105                 110         


Tyr Thr Cys Ser Val Gln Thr Asp Asn His Pro Lys Thr Ser Arg Val 
        115                 120                 125             


His Leu Ile Val Gln Val Ser Pro Lys Ile Val Glu Ile Ser Ser Asp 
    130                 135                 140                 


Ile Ser Ile Asn Glu Gly Asn Asn Ile Ser Leu Thr Cys Ile Ala Thr 
145                 150                 155                 160 


Gly Arg Pro Glu Pro Thr Val Thr Trp Arg His Ile Ser Pro Lys Ala 
                165                 170                 175     


Val Gly Phe Val Ser Glu Asp Glu Tyr Leu Glu Ile Gln Gly Ile Thr 
            180                 185                 190         


Arg Glu Gln Ser Gly Asp Tyr Glu Cys Ser Ala Ser Asn Asp Val Ala 
        195                 200                 205             


Ala Pro Val Val Arg Arg Val Lys Val Thr Val Asn Tyr Pro Pro Tyr 
    210                 215                 220                 


Ile Ser Glu Ala Lys Gly Thr Gly Val Pro Val Gly Gln Lys Gly Thr 
225                 230                 235                 240 


Leu Gln Cys Glu Ala Ser Ala Val Pro Ser Ala Glu Phe Gln Trp Tyr 
                245                 250                 255     


Lys Asp Asp Lys Arg Leu Ile Glu Gly Lys Lys Gly Val Lys Val Glu 
            260                 265                 270         


Asn Arg Pro Phe Leu Ser Lys Leu Ile Phe Phe Asn Val Ser Glu His 
        275                 280                 285             


Asp Tyr Gly Asn Tyr Thr Cys Val Ala Ser Asn Lys Leu Gly His Thr 
    290                 295                 300                 


Asn Ala Ser Ile Met Leu Phe Gly Pro Gly Ala Val Ser Glu Val Ser 
305                 310                 315                 320 


Asn Gly Thr Ser Arg Arg Ala Gly Cys Val Trp Leu Leu Pro Leu Leu 
                325                 330                 335     


Val Leu His Leu Leu Leu Lys Phe 
            340                 


<210>  4235
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  4235

Met Gln Asp Glu Glu Arg Tyr Met Thr Leu Asn Val Gln Ser Lys Lys 
1               5                   10                  15      


Arg Ser Ser Ala Gln Thr Ser Gln Leu Thr Phe Lys Asp Tyr Ser Val 
            20                  25                  30          


Thr Leu His Trp Tyr Lys Ile Leu Leu Gly Ile Ser Gly Thr Val Asn 
        35                  40                  45              


Gly Ile Leu Thr Leu Thr Leu Ile Ser Leu Ile Leu Leu Val Ser Gln 
    50                  55                  60                  


Gly Val Leu Leu Lys Cys Gln Lys Gly Ser Cys Ser Asn Ala Thr Gln 
65                  70                  75                  80  


Tyr Glu Asp Thr Gly Asp Leu Lys Val Asn Asn Gly Thr Arg Arg Asn 
                85                  90                  95      


Ile Ser Asn Lys Asp Leu Cys Ala Ser Arg Ser Ala Asp Gln Thr Val 
            100                 105                 110         


Leu Cys Gln Ser Glu Trp Leu Lys Tyr Gln Gly Lys Cys Tyr Trp Phe 
        115                 120                 125             


Ser Asn Glu Met Lys Ser Trp Ser Asp Ser Tyr Val Tyr Cys Leu Glu 
    130                 135                 140                 


Arg Lys Ser His Leu Leu Ile Ile His Asp Gln Leu Glu Met Ala Phe 
145                 150                 155                 160 


Ile Gln Lys Asn Leu Arg Gln Leu Asn Tyr Val Trp Ile Gly Leu Asn 
                165                 170                 175     


Phe Thr Ser Leu Lys Met Thr Trp Thr Trp Val Asp Gly Ser Pro Ile 
            180                 185                 190         


Asp Ser Lys Ile Phe Phe Ile Lys Gly Pro Ala Lys Glu Asn Ser Cys 
        195                 200                 205             


Ala Ala Ile Lys Glu Ser Lys Ile Phe Ser Glu Thr Cys Ser Ser Val 
    210                 215                 220                 


Phe Lys Trp Ile Cys Gln Tyr 
225                 230     


<210>  4236
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  4236

Met Ala Asp Trp Ala Arg Ala Gln Ser Pro Gly Ala Val Glu Glu Ile 
1               5                   10                  15      


Leu Asp Arg Glu Asn Lys Arg Met Ala Asp Ser Leu Ala Ser Lys Val 
            20                  25                  30          


Thr Arg Leu Lys Ser Leu Ala Leu Asp Ile Asp Arg Asp Ala Glu Asp 
        35                  40                  45              


Gln Asn Arg Tyr Leu Asp Gly Met Val Arg Ala His Gly Val Arg Val 
    50                  55                  60                  


Ser Val Pro Cys Pro Ser Thr Thr Cys Cys Arg Ala Cys Ser Val Ser 
65                  70                  75                  80  


Phe Ser Thr Gly Ala Gly Gly Trp Ser Asn His His Phe Cys Val Ile 
                85                  90                  95      


Leu Leu Gly Phe Leu Pro 
            100         


<210>  4237
<211>  1188
<212>  PRT
<213>  Homo sapiens

<400>  4237

Met Leu Asn Gly Ala Gly Leu Asp Lys Ala Leu Lys Met Ser Leu Pro 
1               5                   10                  15      


Arg Arg Ser Arg Ile Arg Ser Ser Val Gly Pro Val Arg Ser Ser Leu 
            20                  25                  30          


Gly Tyr Lys Lys Ala Glu Asp Glu Met Ser Arg Ala Thr Ser Val Gly 
        35                  40                  45              


Asp Gln Leu Glu Ala Pro Ala Arg Thr Ile Tyr Leu Asn Gln Pro His 
    50                  55                  60                  


Leu Asn Lys Phe Arg Asp Asn Gln Ile Ser Thr Ala Lys Tyr Ser Val 
65                  70                  75                  80  


Leu Thr Phe Leu Pro Arg Phe Leu Tyr Glu Gln Ile Arg Arg Ala Ala 
                85                  90                  95      


Asn Ala Phe Phe Leu Phe Ile Ala Leu Leu Gln Gln Ile Pro Asp Val 
            100                 105                 110         


Ser Pro Thr Gly Arg Tyr Thr Thr Leu Val Pro Leu Ile Ile Ile Leu 
        115                 120                 125             


Thr Ile Ala Gly Ile Lys Glu Ile Val Glu Asp Phe Lys Arg His Lys 
    130                 135                 140                 


Ala Asp Asn Ala Val Asn Lys Lys Lys Thr Ile Val Leu Arg Asn Gly 
145                 150                 155                 160 


Met Trp His Thr Ile Met Trp Lys Glu Val Ala Val Gly Asp Ile Val 
                165                 170                 175     


Lys Val Val Asn Gly Gln Tyr Leu Pro Ala Asp Val Val Leu Leu Ser 
            180                 185                 190         


Ser Ser Glu Pro Gln Ala Met Cys Tyr Val Glu Thr Ala Asn Leu Asp 
        195                 200                 205             


Gly Glu Thr Asn Leu Lys Ile Arg Gln Gly Leu Ser His Thr Ala Asp 
    210                 215                 220                 


Met Gln Thr Arg Glu Val Leu Met Lys Leu Ser Gly Thr Ile Glu Cys 
225                 230                 235                 240 


Glu Gly Pro Asn Arg His Leu Tyr Asp Phe Thr Gly Asn Leu Asn Leu 
                245                 250                 255     


Asp Gly Lys Ser Leu Val Ala Leu Gly Pro Asp Gln Ile Leu Leu Arg 
            260                 265                 270         


Gly Thr Gln Leu Arg Asn Thr Gln Trp Val Phe Gly Ile Val Val Tyr 
        275                 280                 285             


Thr Gly His Asp Thr Lys Leu Met Gln Asn Ser Thr Lys Ala Pro Leu 
    290                 295                 300                 


Lys Arg Ser Asn Val Glu Lys Val Thr Asn Val Gln Ile Leu Val Leu 
305                 310                 315                 320 


Phe Gly Ile Leu Leu Val Met Ala Leu Val Ser Ser Ala Gly Ala Leu 
                325                 330                 335     


Tyr Trp Asn Arg Ser His Gly Glu Lys Asn Trp Tyr Ile Lys Lys Met 
            340                 345                 350         


Asp Thr Thr Ser Asp Asn Phe Gly Tyr Asn Leu Leu Thr Phe Ile Ile 
        355                 360                 365             


Leu Tyr Asn Asn Leu Ile Pro Ile Ser Leu Leu Val Thr Leu Glu Val 
    370                 375                 380                 


Val Lys Tyr Thr Gln Ala Leu Phe Ile Asn Trp Asp Thr Asp Met Tyr 
385                 390                 395                 400 


Tyr Ile Gly Asn Asp Thr Pro Ala Met Ala Arg Thr Ser Asn Leu Asn 
                405                 410                 415     


Glu Glu Leu Gly Gln Val Lys Tyr Leu Phe Ser Asp Lys Thr Gly Thr 
            420                 425                 430         


Leu Thr Cys Asn Ile Met Asn Phe Lys Lys Cys Ser Ile Ala Gly Val 
        435                 440                 445             


Thr Tyr Gly His Phe Pro Glu Leu Ala Arg Glu Pro Ser Ser Asp Asp 
    450                 455                 460                 


Phe Cys Arg Met Pro Pro Pro Cys Ser Asp Ser Cys Asp Phe Asp Asp 
465                 470                 475                 480 


Pro Arg Leu Leu Lys Asn Ile Glu Asp Arg His Pro Thr Ala Pro Cys 
                485                 490                 495     


Ile Gln Glu Phe Leu Thr Leu Leu Ala Val Cys His Thr Val Val Pro 
            500                 505                 510         


Glu Lys Asp Gly Asp Asn Ile Ile Tyr Gln Ala Ser Ser Pro Asp Glu 
        515                 520                 525             


Ala Ala Leu Val Lys Gly Ala Lys Lys Leu Gly Phe Val Phe Thr Ala 
    530                 535                 540                 


Arg Thr Pro Phe Ser Val Ile Ile Glu Ala Met Gly Gln Glu Gln Thr 
545                 550                 555                 560 


Phe Gly Ile Leu Asn Val Leu Glu Phe Ser Ser Asp Arg Lys Arg Met 
                565                 570                 575     


Ser Val Ile Val Arg Thr Pro Ser Gly Arg Leu Arg Leu Tyr Cys Lys 
            580                 585                 590         


Gly Ala Asp Asn Val Ile Phe Glu Arg Leu Ser Lys Asp Ser Lys Tyr 
        595                 600                 605             


Met Glu Glu Thr Leu Cys His Leu Glu Tyr Phe Ala Thr Glu Gly Leu 
    610                 615                 620                 


Arg Thr Leu Cys Val Ala Tyr Ala Asp Leu Ser Glu Asn Glu Tyr Glu 
625                 630                 635                 640 


Glu Trp Leu Lys Val Tyr Gln Glu Ala Ser Thr Ile Leu Lys Asp Arg 
                645                 650                 655     


Ala Gln Arg Leu Glu Glu Cys Tyr Glu Ile Ile Glu Lys Asn Leu Leu 
            660                 665                 670         


Leu Leu Gly Ala Thr Ala Ile Glu Asp Arg Leu Gln Ala Gly Val Pro 
        675                 680                 685             


Glu Thr Ile Ala Thr Leu Leu Lys Ala Glu Ile Lys Ile Trp Val Leu 
    690                 695                 700                 


Thr Gly Asp Lys Gln Glu Thr Ala Ile Asn Ile Gly Tyr Ser Cys Arg 
705                 710                 715                 720 


Leu Val Ser Gln Asn Met Ala Leu Ile Leu Leu Lys Glu Asp Ser Leu 
                725                 730                 735     


Asp Ala Thr Arg Ala Ala Ile Thr Gln His Cys Thr Asp Leu Gly Asn 
            740                 745                 750         


Leu Leu Gly Lys Glu Asn Asp Val Ala Leu Ile Ile Asp Gly His Thr 
        755                 760                 765             


Leu Lys Tyr Ala Leu Ser Phe Glu Val Arg Arg Ser Phe Leu Asp Leu 
    770                 775                 780                 


Ala Leu Ser Cys Lys Ala Val Ile Cys Cys Arg Val Ser Pro Leu Gln 
785                 790                 795                 800 


Lys Ser Glu Ile Val Asp Val Val Lys Lys Arg Val Lys Ala Ile Thr 
                805                 810                 815     


Leu Ala Ile Gly Asp Gly Ala Asn Asp Val Gly Met Ile Gln Thr Ala 
            820                 825                 830         


His Val Gly Val Gly Ile Ser Gly Asn Glu Gly Met Gln Ala Thr Asn 
        835                 840                 845             


Asn Ser Asp Tyr Ala Ile Ala Gln Phe Ser Tyr Leu Glu Lys Leu Leu 
    850                 855                 860                 


Leu Val His Gly Ala Trp Ser Tyr Asn Arg Val Thr Lys Cys Ile Leu 
865                 870                 875                 880 


Tyr Cys Phe Tyr Lys Asn Val Val Leu Tyr Ile Ile Glu Leu Trp Phe 
                885                 890                 895     


Ala Phe Val Asn Gly Phe Ser Gly Gln Ile Leu Phe Glu Arg Trp Cys 
            900                 905                 910         


Ile Gly Leu Tyr Asn Val Ile Phe Thr Ala Leu Pro Pro Phe Thr Leu 
        915                 920                 925             


Gly Ile Phe Glu Arg Ser Cys Thr Gln Glu Ser Met Leu Arg Phe Pro 
    930                 935                 940                 


Gln Leu Tyr Lys Ile Thr Gln Asn Gly Glu Gly Phe Asn Thr Lys Val 
945                 950                 955                 960 


Phe Trp Gly His Cys Ile Asn Ala Leu Val His Ser Leu Ile Leu Phe 
                965                 970                 975     


Trp Phe Pro Met Lys Ala Leu Glu His Asp Thr Val Leu Thr Ser Gly 
            980                 985                 990         


His Ala Thr Asp Tyr Leu Phe Val  Gly Asn Ile Val Tyr  Thr Tyr Val 
        995                 1000                 1005             


Val Val  Thr Val Cys Leu Lys  Ala Gly Leu Glu Thr  Thr Ala Trp 
    1010                 1015                 1020             


Thr Lys  Phe Ser His Leu Ala  Val Trp Gly Ser Met  Leu Thr Trp 
    1025                 1030                 1035             


Leu Val  Phe Phe Gly Ile Tyr  Ser Thr Ile Trp Pro  Thr Ile Pro 
    1040                 1045                 1050             


Ile Ala  Pro Asp Met Arg Gly  Gln Ala Thr Met Val  Leu Ser Ser 
    1055                 1060                 1065             


Ala His  Phe Trp Leu Gly Leu  Phe Leu Val Pro Thr  Ala Cys Leu 
    1070                 1075                 1080             


Ile Glu  Asp Val Ala Trp Arg  Ala Ala Lys His Thr  Cys Lys Lys 
    1085                 1090                 1095             


Thr Leu  Leu Glu Glu Val Gln  Glu Leu Glu Thr Lys  Ser Arg Val 
    1100                 1105                 1110             


Leu Gly  Lys Ala Val Leu Arg  Asp Ser Asn Gly Lys  Arg Leu Asn 
    1115                 1120                 1125             


Glu Arg  Asp Arg Leu Ile Lys  Arg Leu Gly Arg Lys  Thr Pro Pro 
    1130                 1135                 1140             


Thr Leu  Phe Arg Gly Ser Ser  Leu Gln Gln Gly Val  Pro His Gly 
    1145                 1150                 1155             


Tyr Ala  Phe Ser Gln Glu Glu  His Gly Ala Val Ser  Gln Glu Glu 
    1160                 1165                 1170             


Val Ile  Arg Ala Tyr Asp Thr  Thr Lys Lys Lys Ser  Arg Lys Lys 
    1175                 1180                 1185             


<210>  4238
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  4238

Met Ala Gly Leu Ser Arg Gln Leu Cys Ala Leu Ser His Pro Lys Lys 
1               5                   10                  15      


Ala Ala Glu Thr Gln Thr Ala Glu Pro Gly Gly Ala His Ala Val Cys 
            20                  25                  30          


Ser Arg His Pro Val Arg Val Lys Gly Leu Glu Gly Ser Glu Met Glu 
        35                  40                  45              


Ser Ala Arg Glu Asn Ile Asp Leu Gln Pro Gly Ser Ser Asp Pro Arg 
    50                  55                  60                  


Ser Gln Pro Ile Asn Leu Asn His Tyr Ala Thr Lys Lys Ser Val Ala 
65                  70                  75                  80  


Glu Ser Met Leu Asp Val Ala Leu Phe Met Ser Asn Ala Met Arg Leu 
                85                  90                  95      


Lys Ala Val Leu Glu Gln Gly Pro Ser Ser His Tyr Tyr Thr Thr Leu 
            100                 105                 110         


Val Thr Leu Ile Ser Leu Ser Leu Leu Leu Gln Val Val Ile Gly Val 
        115                 120                 125             


Leu Leu Val Val Ile Ala Arg Leu Asn Leu Asn Glu Val Glu Lys Gln 
    130                 135                 140                 


Trp Arg Leu Asn Gln Leu Asn Asn Ala Ala Thr Ile Leu Val Phe Phe 
145                 150                 155                 160 


Thr Val Val Ile Asn Val Phe Ile Thr Ala Phe Gly Ala His Lys Thr 
                165                 170                 175     


Gly Phe Leu Ala Ala Arg Ala Ser Arg Asn Pro Leu 
            180                 185             


<210>  4239
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  4239

Met Val Pro His Leu Leu Leu Leu Cys Leu Leu Pro Leu Val Arg Ala 
1               5                   10                  15      


Thr Glu Pro His Glu Gly Arg Ala Asp Glu Gln Ser Ala Glu Ala Ala 
            20                  25                  30          


Leu Ala Val Pro Asn Ala Ser His Phe Phe Ser Trp Asn Asn Tyr Thr 
        35                  40                  45              


Phe Ser Asp Trp Gln Asn Phe Val Gly Arg Arg Arg Tyr Gly Ala Glu 
    50                  55                  60                  


Ser Gln Asn Pro Thr Val Lys Ala Leu Leu Ile Val Ala Tyr Ser Phe 
65                  70                  75                  80  


Ile Ile Val Phe Ser Leu Phe Gly Asn Val Leu Val Cys His Val Ile 
                85                  90                  95      


Phe Lys Asn Gln Arg Met His Ser Ala Thr Ser Leu Phe Ile Val Asn 
            100                 105                 110         


Leu Ala Val Ala Asp Ile Met Ile Thr Leu Leu Asn Thr Pro Phe Thr 
        115                 120                 125             


Leu Val Arg Phe Val Asn Ser Thr Trp Ile Phe Gly Lys Gly Met Cys 
    130                 135                 140                 


His Val Ser Arg Phe Ala Gln Tyr Cys Ser Leu His Val Ser Ala Leu 
145                 150                 155                 160 


Thr Leu Thr Ala Ile Ala Val Asp Arg His Gln Val Ile Met His Pro 
                165                 170                 175     


Leu Lys Pro Arg Ile Ser Ile Thr Lys Gly Val Ile Tyr Ile Ala Val 
            180                 185                 190         


Ile Trp Thr Met Ala Thr Phe Phe Ser Leu Pro His Ala Ile Cys Gln 
        195                 200                 205             


Lys Leu Phe Thr Phe Lys Tyr Ser Glu Asp Ile Val Arg Ser Leu Cys 
    210                 215                 220                 


Leu Pro Asp Phe Pro Glu Pro Ala Asp Leu Phe Trp Lys Tyr Leu Asp 
225                 230                 235                 240 


Leu Ala Thr Phe Ile Leu Leu Tyr Ile Leu Pro Leu Leu Ile Ile Ser 
                245                 250                 255     


Val Ala Tyr Ala Arg Val Ala Lys Lys Leu Trp Leu Cys Asn Met Ile 
            260                 265                 270         


Gly Asp Val Thr Thr Glu Gln Tyr Phe Ala Leu Arg Arg Lys Lys Lys 
        275                 280                 285             


Lys Thr Ile Lys Met Leu Met Leu Val Val Val Leu Phe Ala Leu Cys 
    290                 295                 300                 


Trp Phe Pro Leu Asn Cys Tyr Val Leu Leu Leu Ser Ser Lys Val Ile 
305                 310                 315                 320 


Arg Thr Asn Asn Ala Leu Tyr Phe Ala Phe His Trp Phe Ala Met Ser 
                325                 330                 335     


Ser Thr Cys Tyr Asn Pro Phe Ile Tyr Cys Trp Leu Asn Glu Asn Phe 
            340                 345                 350         


Arg Ile Glu Leu Lys Ala Leu Leu Ser Met Cys Gln Arg Pro Pro Lys 
        355                 360                 365             


Pro Gln Glu Asp Arg Pro Pro Ser Pro Val Pro Ser Phe Arg Val Ala 
    370                 375                 380                 


Trp Thr Glu Lys Asn Asp Gly Gln Arg Ala Pro Leu Ala Asn Asn Leu 
385                 390                 395                 400 


Leu Pro Thr Ser Gln Leu Gln Ser Gly Lys Thr Asp Leu Ser Ser Val 
                405                 410                 415     


Glu Pro Ile Val Thr Met Ser 
            420             


<210>  4240
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  4240

Met Leu Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg Val 
1               5                   10                  15      


Glu Gly Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln Ser 
            20                  25                  30          


Ser Val Thr Val Gln Glu Gly Met Cys Val His Val Arg Cys Ser Phe 
        35                  40                  45              


Ser Tyr Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly Tyr 
    50                  55                  60                  


Trp Phe Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala Thr 
65                  70                  75                  80  


Asn Asn Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe His 
                85                  90                  95      


Leu Leu Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp 
            100                 105                 110         


Ala Arg Met Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly 
        115                 120                 125             


Asn Ile Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val Thr 
    130                 135                 140                 


Asp Pro Pro Gln Asn Leu Thr Val Thr Val Phe Gln Gly Glu Gly Thr 
145                 150                 155                 160 


Ala Ser Thr Ala Leu Gly Asn Ser Ser Ser Leu Ser Val Leu Glu Gly 
                165                 170                 175     


Gln Ser Leu Arg Leu Val Cys Ala Val Asp Ser Asn Pro Pro Ala Arg 
            180                 185                 190         


Leu Ser Trp Thr Trp Arg Ser Leu Thr Leu Tyr Pro Ser Gln Pro Ser 
        195                 200                 205             


Asn Pro Leu Val Leu Glu Leu Gln Val His Leu Gly Asp Glu Gly Glu 
    210                 215                 220                 


Phe Thr Cys Arg Ala Gln Asn Ser Leu Gly Ser Gln His Val Ser Leu 
225                 230                 235                 240 


Asn Leu Ser Leu Gln Gln Glu Tyr Thr Gly Lys Met Arg Pro Val Ser 
                245                 250                 255     


Gly Val Leu Leu Gly Ala Val Gly Gly Ala Gly Ala Thr Ala Leu Val 
            260                 265                 270         


Phe Leu Ser Phe Cys Val Ile Phe Ile Val Val Arg Ser Cys Arg Lys 
        275                 280                 285             


Lys Ser Ala Arg Pro Ala Ala Asp Val Gly Asp Ile Gly Met Lys Asp 
    290                 295                 300                 


Ala Asn Thr Ile Arg Gly Ser Ala Ser Gln Gly Asn Leu Thr Glu Ser 
305                 310                 315                 320 


Trp Ala Asp Asp Asn Pro Arg His His Gly Leu Ala Ala His Ser Ser 
                325                 330                 335     


Gly Glu Glu Arg Glu Ile Gln Tyr Ala Pro Leu Ser Phe His Lys Gly 
            340                 345                 350         


Glu Pro Gln Asp Leu Ser Gly Gln Glu Ala Thr Asn Asn Glu Tyr Ser 
        355                 360                 365             


Glu Ile Lys Ile Pro Lys 
    370                 


<210>  4241
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  4241

Met Met Gly Leu Gly Asn Gly Arg Arg Ser Met Lys Ser Pro Pro Leu 
1               5                   10                  15      


Val Leu Ala Ala Leu Val Ala Cys Ile Ile Val Leu Gly Phe Asn Tyr 
            20                  25                  30          


Trp Ile Ala Ser Ser Arg Ser Val Asp Leu Gln Thr Arg Ile Met Glu 
        35                  40                  45              


Leu Glu Gly Arg Val Arg Arg Ala Ala Ala Glu Arg Gly Ala Val Glu 
    50                  55                  60                  


Leu Lys Lys Asn Glu Phe Gln Gly Glu Leu Glu Lys Gln Arg Glu Gln 
65                  70                  75                  80  


Leu Asp Lys Ile Gln Ser Ser His Asn Phe Gln Leu Glu Ser Val Asn 
                85                  90                  95      


Lys Leu Tyr Gln Asp Glu Lys Ala Val Leu Val Asn Asn Ile Thr Thr 
            100                 105                 110         


Gly Glu Arg Leu Ile Arg Val Leu Gln Asp Gln Leu Lys Thr Leu Gln 
        115                 120                 125             


Arg Asn Tyr Gly Arg Leu Gln Gln Asp Val Leu Gln Phe Gln Lys Asn 
    130                 135                 140                 


Gln Thr Asn Leu Glu Arg Lys Phe Ser Tyr Asp Leu Ser Gln Cys Ile 
145                 150                 155                 160 


Asn Gln Met Lys Glu Val Lys Glu Gln Cys Glu Glu Arg Ile Glu Glu 
                165                 170                 175     


Val Thr Lys Lys Gly Asn Glu Ala Val Ala Ser Arg Asp Leu Ser Glu 
            180                 185                 190         


Asn Asn Asp Gln Arg Gln Gln Leu Gln Ala Leu Ser Glu Pro Gln Pro 
        195                 200                 205             


Arg Leu Gln Ala Ala Gly Leu Pro His Thr Glu Val Pro Gln Gly Lys 
    210                 215                 220                 


Gly Asn Val Leu Gly Asn Ser Lys Ser Gln Thr Pro Ala Pro Ser Ser 
225                 230                 235                 240 


Glu Val Val Leu Asp Ser Lys Arg Gln Val Glu Lys Glu Glu Thr Asn 
                245                 250                 255     


Glu Ile Gln Val Val Asn Glu Glu Pro Gln Arg Asp Arg Leu Pro Gln 
            260                 265                 270         


Glu Pro Gly Arg Glu Gln Val Val Glu Asp Arg Pro Val Gly Gly Arg 
        275                 280                 285             


Gly Phe Gly Gly Ala Gly Glu Leu Gly Gln Thr Pro Gln Val Gln Ala 
    290                 295                 300                 


Ala Leu Ser Val Ser Gln Glu Asn Pro Glu Met Glu Gly Pro Glu Arg 
305                 310                 315                 320 


Asp Gln Leu Val Ile Pro Asp Gly Gln Glu Glu Glu Gln Glu Ala Ala 
                325                 330                 335     


Gly Glu Gly Arg Asn Gln Gln Lys Leu Arg Gly Glu Asp Asp Tyr Asn 
            340                 345                 350         


Met Asp Glu Asn Glu Ala Glu Ser Glu Thr Asp Lys Gln Ala Ala Leu 
        355                 360                 365             


Ala Gly Asn Asp Arg Asn Ile Asp Val Phe Asn Val Glu Asp Gln Lys 
    370                 375                 380                 


Arg Asp Thr Ile Asn Leu Leu Asp Gln Arg Glu Lys Arg Asn His Thr 
385                 390                 395                 400 


Leu 
    


<210>  4242
<211>  570
<212>  PRT
<213>  Homo sapiens

<400>  4242

Met Gly Phe Leu Gln Leu Leu Val Val Ala Val Leu Ala Ser Glu His 
1               5                   10                  15      


Arg Val Ala Gly Ala Ala Glu Val Phe Gly Asn Ser Ser Glu Gly Leu 
            20                  25                  30          


Ile Glu Phe Ser Val Gly Lys Phe Arg Tyr Phe Glu Leu Asn Arg Pro 
        35                  40                  45              


Phe Pro Glu Glu Ala Ile Leu His Asp Ile Ser Ser Asn Val Thr Phe 
    50                  55                  60                  


Leu Ile Phe Gln Ile His Ser Gln Tyr Gln Asn Thr Thr Val Ser Phe 
65                  70                  75                  80  


Ser Pro Thr Leu Leu Ser Asn Ser Ser Glu Thr Gly Thr Ala Ser Gly 
                85                  90                  95      


Leu Val Phe Ile Leu Arg Pro Glu Gln Ser Thr Cys Thr Trp Tyr Leu 
            100                 105                 110         


Gly Thr Ser Gly Ile Gln Pro Val Gln Asn Met Ala Ile Leu Leu Ser 
        115                 120                 125             


Tyr Ser Glu Arg Asp Pro Val Pro Gly Gly Cys Asn Leu Glu Phe Asp 
    130                 135                 140                 


Leu Asp Ile Asp Pro Asn Ile Tyr Leu Glu Tyr Asn Phe Phe Glu Thr 
145                 150                 155                 160 


Thr Ile Lys Phe Ala Pro Ala Asn Leu Gly Tyr Ala Arg Gly Val Asp 
                165                 170                 175     


Pro Pro Pro Cys Asp Ala Gly Thr Asp Gln Asp Ser Arg Trp Arg Leu 
            180                 185                 190         


Gln Tyr Asp Val Tyr Gln Tyr Phe Leu Pro Glu Asn Asp Leu Thr Glu 
        195                 200                 205             


Glu Met Leu Leu Lys His Leu Gln Arg Met Val Ser Val Pro Gln Val 
    210                 215                 220                 


Lys Ala Ser Ala Leu Lys Val Val Thr Leu Thr Ala Asn Asp Lys Thr 
225                 230                 235                 240 


Ser Val Ser Phe Ser Ser Leu Pro Gly Gln Gly Val Ile Tyr Asn Val 
                245                 250                 255     


Ile Val Trp Asp Pro Phe Leu Asn Thr Ser Ala Ala Tyr Ile Pro Ala 
            260                 265                 270         


His Thr Tyr Ala Cys Ser Phe Glu Ala Gly Glu Gly Ser Cys Ala Ser 
        275                 280                 285             


Leu Gly Arg Val Ser Ser Lys Val Phe Phe Thr Leu Phe Ala Leu Leu 
    290                 295                 300                 


Gly Phe Phe Ile Cys Phe Phe Gly His Arg Phe Trp Lys Thr Glu Leu 
305                 310                 315                 320 


Phe Phe Ile Gly Phe Ile Ile Met Gly Phe Phe Phe Tyr Ile Leu Ile 
                325                 330                 335     


Thr Arg Leu Thr Pro Ile Lys Tyr Asp Val Asn Leu Ile Leu Thr Ala 
            340                 345                 350         


Val Thr Gly Ser Val Gly Gly Met Phe Leu Val Ala Val Trp Trp Arg 
        355                 360                 365             


Phe Gly Ile Leu Ser Ile Cys Met Leu Cys Val Gly Leu Val Leu Gly 
    370                 375                 380                 


Phe Leu Ile Ser Ser Val Thr Phe Phe Thr Pro Leu Gly Asn Leu Lys 
385                 390                 395                 400 


Ile Phe His Asp Asp Gly Val Phe Trp Val Thr Phe Ser Cys Ile Ala 
                405                 410                 415     


Ile Leu Ile Pro Val Val Phe Met Gly Cys Leu Arg Ile Leu Asn Ile 
            420                 425                 430         


Leu Thr Cys Gly Val Ile Gly Ser Tyr Ser Val Val Leu Ala Ile Asp 
        435                 440                 445             


Ser Tyr Trp Ser Thr Ser Leu Ser Tyr Ile Thr Leu Asn Val Leu Lys 
    450                 455                 460                 


Arg Ala Leu Asn Lys Asp Phe His Arg Ala Phe Thr Asn Val Pro Phe 
465                 470                 475                 480 


Gln Thr Asn Asp Phe Ile Ile Leu Ala Val Trp Gly Met Leu Ala Val 
                485                 490                 495     


Ser Gly Ile Thr Leu Gln Ile Arg Arg Glu Arg Gly Arg Pro Phe Phe 
            500                 505                 510         


Pro Pro His Pro Tyr Lys Leu Trp Lys Gln Glu Arg Glu Arg Arg Val 
        515                 520                 525             


Thr Asn Ile Leu Asp Pro Ser Tyr His Ile Pro Pro Leu Arg Glu Arg 
    530                 535                 540                 


Leu Tyr Gly Arg Leu Thr Gln Ile Lys Gly Leu Phe Gln Lys Glu Gln 
545                 550                 555                 560 


Pro Ala Gly Glu Arg Thr Pro Leu Leu Leu 
                565                 570 


<210>  4243
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  4243

Met Glu Glu Pro Gln Lys Ser Tyr Val Asn Thr Met Asp Leu Glu Arg 
1               5                   10                  15      


Asp Glu Pro Leu Lys Ser Thr Gly Pro Gln Ile Ser Val Ser Glu Phe 
            20                  25                  30          


Ser Cys His Cys Cys Tyr Asp Ile Leu Val Asn Pro Thr Thr Leu Asn 
        35                  40                  45              


Cys Gly His Ser Phe Cys Arg His Cys Leu Ala Leu Trp Trp Ala Ser 
    50                  55                  60                  


Ser Lys Lys Thr Glu Cys Pro Glu Cys Arg Glu Lys Trp Glu Gly Phe 
65                  70                  75                  80  


Pro Lys Val Ser Ile Leu Leu Arg Asp Ala Ile Glu Lys Leu Phe Pro 
                85                  90                  95      


Asp Ala Ile Arg Leu Arg Phe Glu Asp Ile Gln Gln Asn Asn Asp Ile 
            100                 105                 110         


Val Gln Ser Leu Ala Ala Phe Gln Lys Tyr Gly Asn Asp Gln Ile Pro 
        115                 120                 125             


Leu Ala Pro Asn Thr Gly Arg Ala Asn Gln Gln Met Gly Gly Gly Phe 
    130                 135                 140                 


Phe Ser Gly Val Leu Thr Ala Leu Thr Gly Val Ala Val Val Leu Leu 
145                 150                 155                 160 


Val Tyr His Trp Ser Ser Arg Glu Ser Glu His Asp Leu Leu Val His 
                165                 170                 175     


Lys Ala Val Ala Lys Trp Thr Ala Glu Glu Val Val Leu Trp Leu Glu 
            180                 185                 190         


Gln Leu Gly Pro Trp Ala Ser Leu Tyr Arg Glu Arg Phe Leu Ser Glu 
        195                 200                 205             


Arg Val Asn Gly Arg Leu Leu Leu Thr Leu Thr Glu Glu Glu Phe Ser 
    210                 215                 220                 


Lys Thr Pro Tyr Thr Ile Glu Asn Ser Ser His Arg Arg Ala Ile Leu 
225                 230                 235                 240 


Met Glu Leu Glu Arg Val Lys Ala Leu Gly Val Lys Pro Pro Gln Asn 
                245                 250                 255     


Leu Trp Glu Tyr Lys Ala Val Asn Pro Gly Arg Ser Leu Phe Leu Leu 
            260                 265                 270         


Tyr Ala Leu Lys Ser Ser Pro Arg Leu Ser Leu Leu Tyr Leu Tyr Leu 
        275                 280                 285             


Phe Asp Tyr Thr Asp Thr Phe Leu Pro Phe Ile His Thr Ile Cys Pro 
    290                 295                 300                 


Leu Gln Glu Asp Ser Ser Gly Glu Asp Ile Val Thr Lys Leu Leu Asp 
305                 310                 315                 320 


Leu Lys Glu Pro Thr Trp Lys Gln Trp Arg Glu Phe Leu Val Lys Tyr 
                325                 330                 335     


Ser Phe Leu Pro Tyr Gln Leu Ile Ala Glu Phe Ala Trp Asp Trp Leu 
            340                 345                 350         


Glu Val His Tyr Trp Thr Ser Arg Phe Leu Ile Ile Asn Ala Met Leu 
        355                 360                 365             


Leu Ser Val Leu Glu Leu Phe Ser Phe Trp Arg Ile Trp Ser Arg Ser 
    370                 375                 380                 


Glu Leu Lys Thr Val Pro Gln Arg Met Trp Ser His Phe Trp Lys Val 
385                 390                 395                 400 


Ser Thr Gln Gly Leu Phe Val Ala Met Phe Trp Pro Leu Ile Pro Gln 
                405                 410                 415     


Phe Val Cys Asn Cys Leu Phe Tyr Trp Ala Leu Tyr Phe Asn Pro Ile 
            420                 425                 430         


Ile Asn Ile Asp Leu Val Val Lys Glu Leu Arg Arg Leu Glu Thr Gln 
        435                 440                 445             


Val Leu 
    450 


<210>  4244
<211>  1049
<212>  PRT
<213>  Homo sapiens

<400>  4244

Met Val Phe Pro Met Trp Thr Leu Lys Arg Gln Ile Leu Ile Leu Phe 
1               5                   10                  15      


Asn Ile Ile Leu Ile Ser Lys Leu Leu Gly Ala Arg Trp Phe Pro Lys 
            20                  25                  30          


Thr Leu Pro Cys Asp Val Thr Leu Asp Val Pro Lys Asn His Val Ile 
        35                  40                  45              


Val Asp Cys Thr Asp Lys His Leu Thr Glu Ile Pro Gly Gly Ile Pro 
    50                  55                  60                  


Thr Asn Thr Thr Asn Leu Thr Leu Thr Ile Asn His Ile Pro Asp Ile 
65                  70                  75                  80  


Ser Pro Ala Ser Phe His Arg Leu Asp His Leu Val Glu Ile Asp Phe 
                85                  90                  95      


Arg Cys Asn Cys Val Pro Ile Pro Leu Gly Ser Lys Asn Asn Met Cys 
            100                 105                 110         


Ile Lys Arg Leu Gln Ile Lys Pro Arg Ser Phe Ser Gly Leu Thr Tyr 
        115                 120                 125             


Leu Lys Ser Leu Tyr Leu Asp Gly Asn Gln Leu Leu Glu Ile Pro Gln 
    130                 135                 140                 


Gly Leu Pro Pro Ser Leu Gln Leu Leu Ser Leu Glu Ala Asn Asn Ile 
145                 150                 155                 160 


Phe Ser Ile Arg Lys Glu Asn Leu Thr Glu Leu Ala Asn Ile Glu Ile 
                165                 170                 175     


Leu Tyr Leu Gly Gln Asn Cys Tyr Tyr Arg Asn Pro Cys Tyr Val Ser 
            180                 185                 190         


Tyr Ser Ile Glu Lys Asp Ala Phe Leu Asn Leu Thr Lys Leu Lys Val 
        195                 200                 205             


Leu Ser Leu Lys Asp Asn Asn Val Thr Ala Val Pro Thr Val Leu Pro 
    210                 215                 220                 


Ser Thr Leu Thr Glu Leu Tyr Leu Tyr Asn Asn Met Ile Ala Lys Ile 
225                 230                 235                 240 


Gln Glu Asp Asp Phe Asn Asn Leu Asn Gln Leu Gln Ile Leu Asp Leu 
                245                 250                 255     


Ser Gly Asn Cys Pro Arg Cys Tyr Asn Ala Pro Phe Pro Cys Ala Pro 
            260                 265                 270         


Cys Lys Asn Asn Ser Pro Leu Gln Ile Pro Val Asn Ala Phe Asp Ala 
        275                 280                 285             


Leu Thr Glu Leu Lys Val Leu Arg Leu His Ser Asn Ser Leu Gln His 
    290                 295                 300                 


Val Pro Pro Arg Trp Phe Lys Asn Ile Asn Lys Leu Gln Glu Leu Asp 
305                 310                 315                 320 


Leu Ser Gln Asn Phe Leu Ala Lys Glu Ile Gly Asp Ala Lys Phe Leu 
                325                 330                 335     


His Phe Leu Pro Ser Leu Ile Gln Leu Asp Leu Ser Phe Asn Phe Glu 
            340                 345                 350         


Leu Gln Val Tyr Arg Ala Ser Met Asn Leu Ser Gln Ala Phe Ser Ser 
        355                 360                 365             


Leu Lys Ser Leu Lys Ile Leu Arg Ile Arg Gly Tyr Val Phe Lys Glu 
    370                 375                 380                 


Leu Lys Ser Phe Asn Leu Ser Pro Leu His Asn Leu Gln Asn Leu Glu 
385                 390                 395                 400 


Val Leu Asp Leu Gly Thr Asn Phe Ile Lys Ile Ala Asn Leu Ser Met 
                405                 410                 415     


Phe Lys Gln Phe Lys Arg Leu Lys Val Ile Asp Leu Ser Val Asn Lys 
            420                 425                 430         


Ile Ser Pro Ser Gly Asp Ser Ser Glu Val Gly Phe Cys Ser Asn Ala 
        435                 440                 445             


Arg Thr Ser Val Glu Ser Tyr Glu Pro Gln Val Leu Glu Gln Leu His 
    450                 455                 460                 


Tyr Phe Arg Tyr Asp Lys Tyr Ala Arg Ser Cys Arg Phe Lys Asn Lys 
465                 470                 475                 480 


Glu Ala Ser Phe Met Ser Val Asn Glu Ser Cys Tyr Lys Tyr Gly Gln 
                485                 490                 495     


Thr Leu Asp Leu Ser Lys Asn Ser Ile Phe Phe Val Lys Ser Ser Asp 
            500                 505                 510         


Phe Gln His Leu Ser Phe Leu Lys Cys Leu Asn Leu Ser Gly Asn Leu 
        515                 520                 525             


Ile Ser Gln Thr Leu Asn Gly Ser Glu Phe Gln Pro Leu Ala Glu Leu 
    530                 535                 540                 


Arg Tyr Leu Asp Phe Ser Asn Asn Arg Leu Asp Leu Leu His Ser Thr 
545                 550                 555                 560 


Ala Phe Glu Glu Leu His Lys Leu Glu Val Leu Asp Ile Ser Ser Asn 
                565                 570                 575     


Ser His Tyr Phe Gln Ser Glu Gly Ile Thr His Met Leu Asn Phe Thr 
            580                 585                 590         


Lys Asn Leu Lys Val Leu Gln Lys Leu Met Met Asn Asp Asn Asp Ile 
        595                 600                 605             


Ser Ser Ser Thr Ser Arg Thr Met Glu Ser Glu Ser Leu Arg Thr Leu 
    610                 615                 620                 


Glu Phe Arg Gly Asn His Leu Asp Val Leu Trp Arg Glu Gly Asp Asn 
625                 630                 635                 640 


Arg Tyr Leu Gln Leu Phe Lys Asn Leu Leu Lys Leu Glu Glu Leu Asp 
                645                 650                 655     


Ile Ser Lys Asn Ser Leu Ser Phe Leu Pro Ser Gly Val Phe Asp Gly 
            660                 665                 670         


Met Pro Pro Asn Leu Lys Asn Leu Ser Leu Ala Lys Asn Gly Leu Lys 
        675                 680                 685             


Ser Phe Ser Trp Lys Lys Leu Gln Cys Leu Lys Asn Leu Glu Thr Leu 
    690                 695                 700                 


Asp Leu Ser His Asn Gln Leu Thr Thr Val Pro Glu Arg Leu Ser Asn 
705                 710                 715                 720 


Cys Ser Arg Ser Leu Lys Asn Leu Ile Leu Lys Asn Asn Gln Ile Arg 
                725                 730                 735     


Ser Leu Thr Lys Tyr Phe Leu Gln Asp Ala Phe Gln Leu Arg Tyr Leu 
            740                 745                 750         


Asp Leu Ser Ser Asn Lys Ile Gln Met Ile Gln Lys Thr Ser Phe Pro 
        755                 760                 765             


Glu Asn Val Leu Asn Asn Leu Lys Met Leu Leu Leu His His Asn Arg 
    770                 775                 780                 


Phe Leu Cys Thr Cys Asp Ala Val Trp Phe Val Trp Trp Val Asn His 
785                 790                 795                 800 


Thr Glu Val Thr Ile Pro Tyr Leu Ala Thr Asp Val Thr Cys Val Gly 
                805                 810                 815     


Pro Gly Ala His Lys Gly Gln Ser Val Ile Ser Leu Asp Leu Tyr Thr 
            820                 825                 830         


Cys Glu Leu Asp Leu Thr Asn Leu Ile Leu Phe Ser Leu Ser Ile Ser 
        835                 840                 845             


Val Ser Leu Phe Leu Met Val Met Met Thr Ala Ser His Leu Tyr Phe 
    850                 855                 860                 


Trp Asp Val Trp Tyr Ile Tyr His Phe Cys Lys Ala Lys Ile Lys Gly 
865                 870                 875                 880 


Tyr Gln Arg Leu Ile Ser Pro Asp Cys Cys Tyr Asp Ala Phe Ile Val 
                885                 890                 895     


Tyr Asp Thr Lys Asp Pro Ala Val Thr Glu Trp Val Leu Ala Glu Leu 
            900                 905                 910         


Val Ala Lys Leu Glu Asp Pro Arg Glu Lys His Phe Asn Leu Cys Leu 
        915                 920                 925             


Glu Glu Arg Asp Trp Leu Pro Gly Gln Pro Val Leu Glu Asn Leu Ser 
    930                 935                 940                 


Gln Ser Ile Gln Leu Ser Lys Lys Thr Val Phe Val Met Thr Asp Lys 
945                 950                 955                 960 


Tyr Ala Lys Thr Glu Asn Phe Lys Ile Ala Phe Tyr Leu Ser His Gln 
                965                 970                 975     


Arg Leu Met Asp Glu Lys Val Asp Val Ile Ile Leu Ile Phe Leu Glu 
            980                 985                 990         


Lys Pro Phe Gln Lys Ser Lys Phe  Leu Gln Leu Arg Lys  Arg Leu Cys 
        995                 1000                 1005             


Gly Ser  Ser Val Leu Glu Trp  Pro Thr Asn Pro Gln  Ala His Pro 
    1010                 1015                 1020             


Tyr Phe  Trp Gln Cys Leu Lys  Asn Ala Leu Ala Thr  Asp Asn His 
    1025                 1030                 1035             


Val Ala  Tyr Ser Gln Val Phe  Lys Glu Thr Val 
    1040                 1045                 


<210>  4245
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  4245

Met Glu Ser Arg Gly Lys Ser Ala Ser Ser Pro Lys Pro Asp Thr Lys 
1               5                   10                  15      


Val Pro Gln Val Thr Thr Glu Ala Lys Val Pro Pro Ala Ala Asp Gly 
            20                  25                  30          


Lys Ala Pro Leu Thr Lys Pro Ser Lys Lys Glu Ala Pro Ala Glu Lys 
        35                  40                  45              


Gln Gln Pro Pro Ala Ala Pro Thr Thr Ala Pro Ala Lys Lys Thr Ser 
    50                  55                  60                  


Ala Lys Ala Asp Pro Ala Leu Leu Asn Asn His Ser Asn Leu Lys Pro 
65                  70                  75                  80  


Ala Pro Thr Val Pro Ser Ser Pro Asp Ala Thr Pro Glu Pro Lys Gly 
                85                  90                  95      


Pro Gly Asp Gly Ala Glu Glu Asp Glu Ala Ala Ser Gly Gly Pro Gly 
            100                 105                 110         


Gly Arg Gly Pro Trp Ser Cys Glu Asn Phe Asn Pro Leu Leu Val Ala 
        115                 120                 125             


Gly Gly Val Ala Val Ala Ala Ile Ala Leu Ile Leu Gly Val Ala Phe 
    130                 135                 140                 


Leu Val Arg Lys Lys 
145                 


<210>  4246
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  4246

Met Gln Met Ala Asp Ala Ala Thr Ile Ala Thr Met Asn Lys Ala Ala 
1               5                   10                  15      


Gly Gly Asp Lys Leu Ala Glu Leu Phe Ser Leu Val Pro Asp Leu Leu 
            20                  25                  30          


Glu Ala Ala Asn Thr Ser Gly Asn Ala Ser Leu Gln Leu Pro Asp Leu 
        35                  40                  45              


Trp Trp Glu Leu Gly Leu Glu Leu Pro Asp Gly Ala Pro Pro Gly His 
    50                  55                  60                  


Pro Pro Gly Ser Gly Gly Ala Glu Ser Ala Asp Thr Glu Ala Arg Val 
65                  70                  75                  80  


Arg Ile Leu Ile Ser Val Val Tyr Trp Val Val Cys Ala Leu Gly Leu 
                85                  90                  95      


Ala Gly Asn Leu Leu Val Leu Tyr Leu Met Lys Ser Met Gln Gly Trp 
            100                 105                 110         


Arg Lys Ser Ser Ile Asn Leu Phe Val Thr Asn Leu Ala Leu Thr Asp 
        115                 120                 125             


Phe Gln Phe Val Leu Thr Leu Pro Phe Trp Ala Val Glu Asn Ala Leu 
    130                 135                 140                 


Asp Phe Lys Trp Pro Phe Gly Lys Ala Met Cys Lys Ile Val Ser Met 
145                 150                 155                 160 


Val Thr Ser Met Asn Met Tyr Ala Ser Val Phe Phe Leu Thr Ala Met 
                165                 170                 175     


Ser Val Thr Arg Tyr His Ser Val Ala Ser Ala Leu Lys Ser His Arg 
            180                 185                 190         


Thr Arg Gly His Gly Arg Gly Asp Cys Cys Gly Arg Ser Leu Gly Asp 
        195                 200                 205             


Ser Cys Cys Phe Ser Ala Lys Ala Leu Cys Val Trp Ile Trp Ala Leu 
    210                 215                 220                 


Ala Ala Leu Ala Ser Leu Pro Ser Ala Ile Phe Ser Thr Thr Val Lys 
225                 230                 235                 240 


Val Met Gly Glu Glu Leu Cys Leu Val Arg Phe Pro Asp Lys Leu Leu 
                245                 250                 255     


Gly Arg Asp Arg Gln Phe Trp Leu Gly Leu Tyr His Ser Gln Lys Val 
            260                 265                 270         


Leu Leu Gly Phe Val Leu Pro Leu Gly Ile Ile Ile Leu Cys Tyr Leu 
        275                 280                 285             


Leu Leu Val Arg Phe Ile Ala Asp Arg Arg Ala Ala Gly Thr Lys Gly 
    290                 295                 300                 


Gly Ala Ala Val Ala Gly Gly Arg Pro Thr Gly Ala Ser Ala Arg Arg 
305                 310                 315                 320 


Leu Ser Lys Val Thr Lys Ser Val Thr Ile Val Val Leu Ser Phe Phe 
                325                 330                 335     


Leu Cys Trp Leu Pro Asn Gln Ala Leu Thr Thr Trp Ser Ile Leu Ile 
            340                 345                 350         


Lys Phe Asn Ala Val Pro Phe Ser Gln Glu Tyr Phe Leu Cys Gln Val 
        355                 360                 365             


Tyr Ala Phe Pro Val Ser Val Cys Leu Ala His Ser Asn Ser Cys Leu 
    370                 375                 380                 


Asn Pro Val Leu Tyr Cys Leu Val Arg Arg Glu Phe Arg Lys Ala Leu 
385                 390                 395                 400 


Lys Ser Leu Leu Trp Arg Ile Ala Ser Pro Ser Ile Thr Ser Met Arg 
                405                 410                 415     


Pro Phe Thr Ala Thr Thr Lys Pro Glu His Glu Asp Gln Gly Leu Gln 
            420                 425                 430         


Ala Pro Ala Pro Pro His Ala Ala Ala Glu Pro Asp Leu Leu Tyr Tyr 
        435                 440                 445             


Pro Pro Gly Val Val Val Tyr Ser Gly Gly Arg Tyr Asp Leu Leu Pro 
    450                 455                 460                 


Ser Ser Ser Ala Tyr 
465                 


<210>  4247
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  4247

Met Arg Arg Leu Asn Arg Lys Lys Thr Leu Ser Leu Val Lys Glu Leu 
1               5                   10                  15      


Asp Ala Phe Pro Lys Val Pro Glu Ser Tyr Val Glu Thr Ser Ala Ser 
            20                  25                  30          


Gly Gly Thr Val Ser Leu Ile Ala Phe Thr Thr Met Ala Leu Leu Thr 
        35                  40                  45              


Ile Met Glu Phe Ser Val Tyr Gln Asp Thr Trp Met Lys Tyr Glu Tyr 
    50                  55                  60                  


Glu Val Asp Lys Asp Phe Ser Ser Lys Leu Arg Ile Asn Ile Asp Ile 
65                  70                  75                  80  


Thr Val Ala Met Lys Cys Gln Tyr Val Gly Ala Asp Val Leu Asp Leu 
                85                  90                  95      


Ala Glu Thr Met Val Ala Ser Ala Asp Gly Leu Val Tyr Glu Pro Thr 
            100                 105                 110         


Val Phe Asp Leu Ser Pro Gln Gln Lys Glu Trp Gln Arg Met Leu Gln 
        115                 120                 125             


Leu Ile Gln Ser Arg Leu Gln Glu Glu His Ser Leu Gln Asp Val Ile 
    130                 135                 140                 


Phe Lys Ser Ala Phe Lys Ser Thr Ser Thr Ala Leu Pro Pro Arg Glu 
145                 150                 155                 160 


Asp Asp Ser Ser Gln Ser Pro Asn Ala Cys Arg Ile His Gly His Leu 
                165                 170                 175     


Tyr Val Asn Lys Val Ala Gly Asn Phe His Ile Thr Val Gly Lys Ala 
            180                 185                 190         


Ile Pro His Pro Arg Gly His Ala His Leu Ala Ala Leu Val Asn His 
        195                 200                 205             


Glu Ser Tyr Asn Phe Ser His Arg Ile Asp His Leu Ser Phe Gly Glu 
    210                 215                 220                 


Leu Val Pro Ala Ile Ile Asn Pro Leu Asp Gly Thr Glu Lys Ile Ala 
225                 230                 235                 240 


Ile Asp His Asn Gln Met Phe Gln Tyr Phe Ile Thr Val Val Pro Thr 
                245                 250                 255     


Lys Leu His Thr Tyr Lys Ile Ser Ala Asp Thr His Gln Phe Ser Val 
            260                 265                 270         


Thr Glu Arg Glu Arg Ile Ile Asn His Ala Ala Gly Ser His Gly Val 
        275                 280                 285             


Ser Gly Ile Phe Met Lys Tyr Asp Leu Ser Ser Leu Met Val Thr Val 
    290                 295                 300                 


Thr Glu Glu His Met Pro Phe Trp Gln Phe Phe Val Arg Leu Cys Gly 
305                 310                 315                 320 


Ile Val Gly Gly Ile Phe Ser Thr Thr Gly Met Leu His Gly Ile Gly 
                325                 330                 335     


Lys Phe Ile Val Glu Ile Ile Cys Cys Arg Phe Arg Leu Gly Ser Tyr 
            340                 345                 350         


Lys Pro Val Asn Ser Val Pro Phe Glu Asp Gly His Thr Asp Asn His 
        355                 360                 365             


Leu Pro Leu Leu Glu Asn Asn Thr His 
    370                 375         


<210>  4248
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  4248

Met Asp Pro Leu Asn Leu Ser Trp Tyr Asp Asp Asp Leu Glu Arg Gln 
1               5                   10                  15      


Asn Trp Ser Arg Pro Phe Asn Gly Ser Asp Gly Lys Ala Asp Arg Pro 
            20                  25                  30          


His Tyr Asn Tyr Tyr Ala Thr Leu Leu Thr Leu Leu Ile Ala Val Ile 
        35                  40                  45              


Val Phe Gly Asn Val Leu Val Cys Met Ala Val Ser Arg Glu Lys Ala 
    50                  55                  60                  


Leu Gln Thr Thr Thr Asn Tyr Leu Ile Val Ser Leu Ala Val Ala Asp 
65                  70                  75                  80  


Leu Leu Val Ala Thr Leu Val Met Pro Trp Val Val Tyr Leu Glu Val 
                85                  90                  95      


Val Gly Glu Trp Lys Phe Ser Arg Ile His Cys Asp Ile Phe Val Thr 
            100                 105                 110         


Leu Asp Val Met Met Cys Thr Ala Ser Ile Leu Asn Leu Cys Ala Ile 
        115                 120                 125             


Ser Ile Asp Arg Tyr Thr Ala Val Ala Met Pro Met Leu Tyr Asn Thr 
    130                 135                 140                 


Arg Tyr Ser Ser Lys Arg Arg Val Thr Val Met Ile Ser Ile Val Trp 
145                 150                 155                 160 


Val Leu Ser Phe Thr Ile Ser Cys Pro Leu Leu Phe Gly Leu Asn Asn 
                165                 170                 175     


Ala Asp Gln Asn Glu Cys Ile Ile Ala Asn Pro Ala Phe Val Val Tyr 
            180                 185                 190         


Ser Ser Ile Val Ser Phe Tyr Val Pro Phe Ile Val Thr Leu Leu Val 
        195                 200                 205             


Tyr Ile Lys Ile Tyr Ile Val Leu Arg Arg Arg Arg Lys Arg Val Asn 
    210                 215                 220                 


Thr Lys Arg Ser Ser Arg Ala Phe Arg Ala His Leu Arg Ala Pro Leu 
225                 230                 235                 240 


Lys Glu Ala Ala Arg Arg Ala Gln Glu Leu Glu Met Glu Met Leu Ser 
                245                 250                 255     


Ser Thr Ser Pro Pro Glu Arg Thr Arg Tyr Ser Pro Ile Pro Pro Ser 
            260                 265                 270         


His His Gln Leu Thr Leu Pro Asp Pro Ser His His Gly Leu His Ser 
        275                 280                 285             


Thr Pro Asp Ser Pro Ala Lys Pro Glu Lys Asn Gly His Ala Lys Asp 
    290                 295                 300                 


His Pro Lys Ile Ala Lys Ile Phe Glu Ile Gln Thr Met Pro Asn Gly 
305                 310                 315                 320 


Lys Thr Arg Thr Ser Leu Lys Thr Met Ser Arg Arg Lys Leu Ser Gln 
                325                 330                 335     


Gln Lys Glu Lys Lys Ala Thr Gln Met Leu Ala Ile Val Leu Gly Val 
            340                 345                 350         


Phe Ile Ile Cys Trp Leu Pro Phe Phe Ile Thr His Ile Leu Asn Ile 
        355                 360                 365             


His Cys Asp Cys Asn Ile Pro Pro Val Leu Tyr Ser Ala Phe Thr Trp 
    370                 375                 380                 


Leu Gly Tyr Val Asn Ser Ala Val Asn Pro Ile Ile Tyr Thr Thr Phe 
385                 390                 395                 400 


Asn Ile Glu Phe Arg Lys Ala Phe Leu Lys Ile Leu His Cys 
                405                 410                 


<210>  4249
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  4249

Met Ser Gly Gly Trp Met Ala Gln Val Gly Ala Trp Arg Thr Gly Ala 
1               5                   10                  15      


Leu Gly Leu Ala Leu Leu Leu Leu Leu Gly Leu Gly Leu Gly Leu Glu 
            20                  25                  30          


Ala Ala Ala Ser Pro Leu Ser Thr Pro Thr Ser Ala Gln Ala Ala Gly 
        35                  40                  45              


Pro Ser Ser Gly Ser Cys Pro Pro Thr Lys Phe Gln Cys Arg Thr Ser 
    50                  55                  60                  


Gly Leu Cys Val Pro Leu Thr Trp Arg Cys Asp Arg Asp Leu Asp Cys 
65                  70                  75                  80  


Ser Asp Gly Ser Asp Glu Glu Glu Cys Arg Ile Glu Pro Cys Thr Gln 
                85                  90                  95      


Lys Gly Gln Cys Pro Pro Pro Pro Gly Leu Pro Cys Pro Cys Thr Gly 
            100                 105                 110         


Val Ser Asp Cys Ser Gly Gly Thr Asp Lys Lys Leu Arg Asn Cys Ser 
        115                 120                 125             


Arg Leu Ala Cys Leu Ala Gly Glu Leu Arg Cys Thr Leu Ser Asp Asp 
    130                 135                 140                 


Cys Ile Pro Leu Thr Trp Arg Cys Asp Gly His Pro Asp Cys Pro Asp 
145                 150                 155                 160 


Ser Ser Asp Glu Leu Gly Cys Gly Thr Asn Glu Ile Leu Pro Glu Gly 
                165                 170                 175     


Asp Ala Thr Thr Met Gly Pro Pro Val Thr Leu Glu Ser Val Thr Ser 
            180                 185                 190         


Leu Arg Asn Ala Thr Thr Met Gly Pro Pro Val Thr Leu Glu Ser Val 
        195                 200                 205             


Pro Ser Val Gly Asn Ala Thr Ser Ser Ser Ala Gly Asp Gln Ser Gly 
    210                 215                 220                 


Ser Pro Thr Ala Tyr Gly Val Ile Ala Ala Ala Ala Val Leu Ser Ala 
225                 230                 235                 240 


Ser Leu Val Thr Ala Thr Leu Leu Leu Leu Ser Trp Leu Arg Ala Gln 
                245                 250                 255     


Glu Arg Leu Arg Pro Leu Gly Leu Leu Val Ala Met Lys Glu Ser Leu 
            260                 265                 270         


Leu Leu Ser Glu Gln Lys Thr Ser Leu Pro 
        275                 280         


<210>  4250
<211>  1184
<212>  PRT
<213>  Homo sapiens

<400>  4250

Met Met Gln Leu Leu Gln Leu Leu Leu Gly Leu Leu Gly Pro Gly Gly 
1               5                   10                  15      


Tyr Leu Phe Leu Leu Gly Asp Cys Gln Glu Val Thr Thr Leu Thr Val 
            20                  25                  30          


Lys Tyr Gln Val Ser Glu Glu Val Pro Ser Gly Thr Val Ile Gly Lys 
        35                  40                  45              


Leu Ser Gln Glu Leu Gly Arg Glu Glu Arg Arg Arg Gln Ala Gly Ala 
    50                  55                  60                  


Ala Phe Gln Val Leu Gln Leu Pro Gln Ala Leu Pro Ile Gln Val Asp 
65                  70                  75                  80  


Ser Glu Glu Gly Leu Leu Ser Thr Gly Arg Arg Leu Asp Arg Glu Gln 
                85                  90                  95      


Leu Cys Arg Gln Trp Asp Pro Cys Leu Val Ser Phe Asp Val Leu Ala 
            100                 105                 110         


Thr Gly Asp Leu Ala Leu Ile His Val Glu Ile Gln Val Leu Asp Ile 
        115                 120                 125             


Asn Asp His Gln Pro Arg Phe Pro Lys Gly Glu Gln Glu Leu Glu Ile 
    130                 135                 140                 


Ser Glu Ser Ala Ser Leu Arg Thr Arg Ile Pro Leu Asp Arg Ala Leu 
145                 150                 155                 160 


Asp Pro Asp Thr Gly Pro Asn Thr Leu His Thr Tyr Thr Leu Ser Pro 
                165                 170                 175     


Ser Glu His Phe Ala Leu Asp Val Ile Val Gly Pro Asp Glu Thr Lys 
            180                 185                 190         


His Ala Glu Leu Ile Val Val Lys Glu Leu Asp Arg Glu Ile His Ser 
        195                 200                 205             


Phe Phe Asp Leu Val Leu Thr Ala Tyr Asp Asn Gly Asn Pro Pro Lys 
    210                 215                 220                 


Ser Gly Thr Ser Leu Val Lys Val Asn Val Leu Asp Ser Asn Asp Asn 
225                 230                 235                 240 


Ser Pro Ala Phe Ala Glu Ser Ser Leu Ala Leu Glu Ile Gln Glu Asp 
                245                 250                 255     


Ala Ala Pro Gly Thr Leu Leu Ile Lys Leu Thr Ala Thr Asp Pro Asp 
            260                 265                 270         


Gln Gly Pro Asn Gly Glu Val Glu Phe Phe Leu Ser Lys His Met Pro 
        275                 280                 285             


Pro Glu Val Leu Asp Thr Phe Ser Ile Asp Ala Lys Thr Gly Gln Val 
    290                 295                 300                 


Ile Leu Arg Arg Pro Leu Asp Tyr Glu Lys Asn Pro Ala Tyr Glu Val 
305                 310                 315                 320 


Asp Val Gln Ala Arg Asp Leu Gly Pro Asn Pro Ile Pro Ala His Cys 
                325                 330                 335     


Lys Val Leu Ile Lys Val Leu Asp Val Asn Asp Asn Ile Pro Ser Ile 
            340                 345                 350         


His Val Thr Trp Ala Ser Gln Pro Ser Leu Val Ser Glu Ala Leu Pro 
        355                 360                 365             


Lys Asp Ser Phe Ile Ala Leu Val Met Ala Asp Asp Leu Asp Ser Gly 
    370                 375                 380                 


His Asn Gly Leu Val His Cys Trp Leu Ser Gln Glu Leu Gly His Phe 
385                 390                 395                 400 


Arg Leu Lys Arg Thr Asn Gly Asn Thr Tyr Met Leu Leu Thr Asn Ala 
                405                 410                 415     


Thr Leu Asp Arg Glu Gln Trp Pro Lys Tyr Thr Leu Thr Leu Leu Ala 
            420                 425                 430         


Gln Asp Gln Gly Leu Gln Pro Leu Ser Ala Lys Lys Gln Leu Ser Ile 
        435                 440                 445             


Gln Ile Ser Asp Ile Asn Asp Asn Ala Pro Val Phe Glu Lys Ser Arg 
    450                 455                 460                 


Tyr Glu Val Ser Thr Arg Glu Asn Asn Leu Pro Ser Leu His Leu Ile 
465                 470                 475                 480 


Thr Ile Lys Ala His Asp Ala Asp Leu Gly Ile Asn Gly Lys Val Ser 
                485                 490                 495     


Tyr Arg Ile Gln Asp Ser Pro Val Ala His Leu Val Ala Ile Asp Ser 
            500                 505                 510         


Asn Thr Gly Glu Val Thr Ala Gln Arg Ser Leu Asn Tyr Glu Glu Met 
        515                 520                 525             


Ala Gly Phe Glu Phe Gln Val Ile Ala Glu Asp Ser Gly Gln Pro Met 
    530                 535                 540                 


Leu Ala Ser Ser Val Ser Val Trp Val Ser Leu Leu Asp Ala Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Glu Val Val Gln Pro Val Leu Ser Asp Gly Lys Ala Ser 
                565                 570                 575     


Leu Ser Val Leu Val Asn Ala Ser Thr Gly His Leu Leu Val Pro Ile 
            580                 585                 590         


Glu Thr Pro Asn Gly Leu Gly Pro Ala Gly Thr Asp Thr Pro Pro Leu 
        595                 600                 605             


Ala Thr His Ser Ser Arg Pro Phe Leu Leu Thr Thr Ile Val Ala Arg 
    610                 615                 620                 


Asp Ala Asp Ser Gly Ala Asn Gly Glu Pro Leu Tyr Ser Ile Arg Ser 
625                 630                 635                 640 


Gly Asn Glu Ala His Leu Phe Ile Leu Asn Pro His Thr Gly Gln Leu 
                645                 650                 655     


Phe Val Asn Val Thr Asn Ala Ser Ser Leu Ile Gly Ser Glu Trp Glu 
            660                 665                 670         


Leu Glu Ile Val Val Glu Asp Gln Gly Ser Pro Pro Leu Gln Thr Arg 
        675                 680                 685             


Ala Leu Leu Arg Val Met Phe Val Thr Ser Val Asp His Leu Arg Asp 
    690                 695                 700                 


Ser Ala Arg Lys Pro Gly Ala Leu Ser Met Ser Met Leu Thr Val Ile 
705                 710                 715                 720 


Cys Leu Ala Val Leu Leu Gly Ile Phe Gly Leu Ile Leu Ala Leu Phe 
                725                 730                 735     


Met Ser Ile Cys Arg Thr Glu Lys Lys Asp Asn Arg Ala Tyr Asn Cys 
            740                 745                 750         


Arg Glu Ala Glu Ser Thr Tyr Arg Gln Gln Pro Lys Arg Pro Gln Lys 
        755                 760                 765             


His Ile Gln Lys Ala Asp Ile His Leu Val Pro Val Leu Arg Gly Gln 
    770                 775                 780                 


Ala Gly Glu Pro Cys Glu Val Gly Gln Ser His Lys Asp Val Asp Lys 
785                 790                 795                 800 


Glu Ala Met Met Glu Ala Gly Trp Asp Pro Cys Leu Gln Ala Pro Phe 
                805                 810                 815     


His Leu Thr Pro Thr Leu Tyr Arg Thr Leu Arg Asn Gln Gly Asn Gln 
            820                 825                 830         


Gly Ala Pro Ala Glu Ser Arg Glu Val Leu Gln Asp Thr Val Asn Leu 
        835                 840                 845             


Leu Phe Asn His Pro Arg Gln Arg Asn Ala Ser Arg Glu Asn Leu Asn 
    850                 855                 860                 


Leu Pro Glu Pro Gln Pro Ala Thr Gly Gln Pro Arg Ser Arg Pro Leu 
865                 870                 875                 880 


Lys Val Ala Gly Ser Pro Thr Gly Arg Leu Ala Gly Asp Gln Gly Ser 
                885                 890                 895     


Glu Glu Ala Pro Gln Arg Pro Pro Ala Ser Ser Ala Thr Leu Arg Arg 
            900                 905                 910         


Gln Arg His Leu Asn Gly Lys Val Ser Pro Glu Lys Glu Ser Gly Pro 
        915                 920                 925             


Arg Gln Ile Leu Arg Ser Leu Val Arg Leu Ser Val Ala Ala Phe Ala 
    930                 935                 940                 


Glu Arg Asn Pro Val Glu Glu Leu Thr Val Asp Ser Pro Pro Val Gln 
945                 950                 955                 960 


Gln Ile Ser Gln Leu Leu Ser Leu Leu His Gln Gly Gln Phe Gln Pro 
                965                 970                 975     


Lys Pro Asn His Arg Gly Asn Lys Tyr Leu Ala Lys Pro Gly Gly Ser 
            980                 985                 990         


Arg Ser Ala Ile Pro Asp Thr Asp  Gly Pro Ser Ala Arg  Ala Gly Gly 
        995                 1000                 1005             


Gln Thr  Asp Pro Glu Gln Glu  Glu Gly Pro Leu Asp  Pro Glu Glu 
    1010                 1015                 1020             


Asp Leu  Ser Val Lys Gln Leu  Leu Glu Glu Glu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Leu Asp  Pro Ser Thr Gly Leu  Ala Leu Asp Arg Leu  Ser Ala Pro 
    1040                 1045                 1050             


Asp Pro  Ala Trp Met Ala Arg  Leu Ser Leu Pro Leu  Thr Thr Asn 
    1055                 1060                 1065             


Tyr Arg  Asp Asn Val Ile Ser  Pro Asp Ala Ala Ala  Thr Glu Glu 
    1070                 1075                 1080             


Pro Arg  Thr Phe Gln Thr Phe  Gly Lys Ala Glu Ala  Pro Glu Leu 
    1085                 1090                 1095             


Ser Pro  Thr Gly Thr Arg Leu  Ala Ser Thr Phe Val  Ser Glu Met 
    1100                 1105                 1110             


Ser Ser  Leu Leu Glu Met Leu  Leu Glu Gln Arg Ser  Ser Met Pro 
    1115                 1120                 1125             


Val Glu  Ala Ala Ser Glu Ala  Leu Arg Arg Leu Ser  Val Cys Gly 
    1130                 1135                 1140             


Arg Thr  Leu Ser Leu Asp Leu  Ala Thr Ser Ala Ala  Ser Gly Met 
    1145                 1150                 1155             


Lys Val  Gln Gly Asp Pro Gly  Gly Lys Thr Gly Thr  Glu Gly Lys 
    1160                 1165                 1170             


Ser Arg  Gly Ser Ser Ser Ser  Ser Arg Cys Leu 
    1175                 1180                 


<210>  4251
<211>  581
<212>  PRT
<213>  Homo sapiens

<400>  4251

Met Pro Ala Pro Arg Ala Arg Glu Gln Pro Arg Val Pro Gly Glu Arg 
1               5                   10                  15      


Gln Pro Leu Leu Pro Arg Gly Ala Arg Gly Pro Arg Arg Trp Arg Arg 
            20                  25                  30          


Ala Ala Gly Ala Ala Val Leu Leu Val Glu Met Leu Glu Arg Ala Ala 
        35                  40                  45              


Phe Phe Gly Val Thr Ala Asn Leu Val Leu Tyr Leu Asn Ser Thr Asn 
    50                  55                  60                  


Phe Asn Trp Thr Gly Glu Gln Ala Thr Arg Ala Ala Leu Val Phe Leu 
65                  70                  75                  80  


Gly Ala Ser Tyr Leu Leu Ala Pro Val Gly Gly Trp Leu Ala Asp Val 
                85                  90                  95      


Tyr Leu Gly Arg Tyr Arg Ala Val Ala Leu Ser Leu Leu Leu Tyr Leu 
            100                 105                 110         


Ala Ala Ser Gly Leu Leu Pro Ala Thr Ala Phe Pro Asp Gly Arg Ser 
        115                 120                 125             


Ser Phe Cys Gly Glu Met Pro Ala Ser Pro Leu Gly Pro Ala Cys Pro 
    130                 135                 140                 


Ser Ala Gly Cys Pro Arg Ser Ser Pro Ser Pro Tyr Cys Ala Pro Val 
145                 150                 155                 160 


Leu Tyr Ala Gly Leu Leu Leu Leu Gly Leu Ala Ala Ser Ser Val Arg 
                165                 170                 175     


Ser Asn Leu Thr Ser Phe Gly Ala Asp Gln Val Met Asp Leu Gly Arg 
            180                 185                 190         


Asp Ala Thr Arg Arg Phe Phe Asn Trp Phe Tyr Trp Ser Ile Asn Leu 
        195                 200                 205             


Gly Ala Val Leu Ser Leu Leu Val Val Ala Phe Ile Gln Gln Asn Ile 
    210                 215                 220                 


Ser Phe Leu Leu Gly Tyr Ser Ile Pro Val Gly Cys Val Gly Leu Ala 
225                 230                 235                 240 


Phe Phe Ile Phe Leu Phe Ala Thr Pro Val Phe Ile Thr Lys Pro Pro 
                245                 250                 255     


Met Gly Ser Gln Val Ser Ser Met Leu Lys Leu Ala Leu Gln Asn Cys 
            260                 265                 270         


Cys Pro Gln Leu Trp Gln Arg His Ser Ala Arg Asp Arg Gln Cys Ala 
        275                 280                 285             


Arg Val Leu Ala Asp Glu Arg Ser Pro Gln Pro Gly Ala Ser Pro Gln 
    290                 295                 300                 


Glu Asp Ile Ala Asn Phe Gln Val Leu Val Lys Ile Leu Pro Val Met 
305                 310                 315                 320 


Val Thr Leu Val Pro Tyr Trp Met Val Tyr Phe Gln Met Gln Ser Thr 
                325                 330                 335     


Tyr Val Leu Gln Gly Leu His Leu His Ile Pro Asn Ile Phe Pro Ala 
            340                 345                 350         


Asn Pro Ala Asn Ile Ser Val Ala Leu Arg Ala Gln Gly Ser Ser Tyr 
        355                 360                 365             


Thr Ile Pro Glu Ala Trp Leu Leu Leu Ala Asn Val Val Val Val Leu 
    370                 375                 380                 


Ile Leu Val Pro Leu Lys Asp Arg Leu Ile Asp Pro Leu Leu Leu Arg 
385                 390                 395                 400 


Cys Lys Leu Leu Pro Ser Ala Leu Gln Lys Met Ala Leu Gly Met Phe 
                405                 410                 415     


Phe Gly Phe Thr Ser Val Ile Val Ala Gly Val Leu Glu Met Glu Arg 
            420                 425                 430         


Leu His Tyr Ile His His Asn Glu Thr Val Ser Gln Gln Ile Gly Glu 
        435                 440                 445             


Val Leu Tyr Asn Ala Ala Pro Leu Ser Ile Trp Trp Gln Ile Pro Gln 
    450                 455                 460                 


Tyr Leu Leu Ile Gly Ile Ser Glu Ile Phe Ala Ser Ile Pro Gly Leu 
465                 470                 475                 480 


Glu Phe Ala Tyr Ser Glu Ala Pro Arg Ser Met Gln Gly Ala Ile Met 
                485                 490                 495     


Gly Ile Phe Phe Cys Leu Ser Gly Val Gly Ser Leu Leu Gly Ser Ser 
            500                 505                 510         


Leu Val Ala Leu Leu Ser Leu Pro Gly Gly Trp Leu His Cys Pro Lys 
        515                 520                 525             


Asp Phe Gly Asn Ile Asn Asn Cys Arg Met Asp Leu Tyr Phe Phe Leu 
    530                 535                 540                 


Leu Ala Gly Ile Gln Ala Val Thr Ala Leu Leu Phe Val Trp Ile Ala 
545                 550                 555                 560 


Gly Arg Tyr Glu Arg Ala Ser Gln Gly Pro Ala Ser His Ser Arg Phe 
                565                 570                 575     


Ser Arg Asp Arg Gly 
            580     


<210>  4252
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  4252

Met Glu Val Pro Pro Pro Ala Pro Arg Ser Phe Leu Cys Arg Ala Leu 
1               5                   10                  15      


Cys Leu Phe Pro Arg Val Phe Ala Ala Glu Ala Val Thr Ala Asp Ser 
            20                  25                  30          


Glu Val Leu Glu Glu Arg Gln Lys Arg Leu Pro Tyr Val Pro Glu Pro 
        35                  40                  45              


Tyr Tyr Pro Glu Ser Gly Trp Asp Arg Leu Arg Glu Leu Phe Gly Lys 
    50                  55                  60                  


Asp Glu Gln Gln Arg Ile Ser Lys Asp Leu Ala Asn Ile Cys Lys Thr 
65                  70                  75                  80  


Ala Ala Thr Ala Gly Ile Ile Gly Trp Val Tyr Gly Gly Ile Pro Ala 
                85                  90                  95      


Phe Ile His Ala Lys Gln Gln Tyr Ile Glu Gln Ser Gln Ala Glu Ile 
            100                 105                 110         


Tyr His Asn Arg Phe Asp Ala Val Gln Ser Ala His Arg Ala Ala Thr 
        115                 120                 125             


Arg Gly Phe Ile Arg Tyr Gly Trp Arg Trp Gly Trp Arg Thr Ala Val 
    130                 135                 140                 


Phe Val Thr Ile Phe Asn Thr Val Asn Thr Ser Leu Asn Val Tyr Arg 
145                 150                 155                 160 


Asn Lys Asp Ala Leu Ser His Phe Val Ile Ala Gly Ala Val Thr Gly 
                165                 170                 175     


Ser Leu Phe Arg Ile Asn Val Gly Leu Arg Gly Leu Val Ala Gly Gly 
            180                 185                 190         


Ile Ile Gly Ala Leu Leu Gly Thr Pro Val Gly Gly Leu Leu Met Ala 
        195                 200                 205             


Phe Gln Lys Tyr Ser Gly Glu Thr Val Gln Glu Arg Lys Gln Lys Asp 
    210                 215                 220                 


Arg Lys Ala Leu His Glu Leu Lys Leu Glu Glu Trp Lys Gly Arg Leu 
225                 230                 235                 240 


Gln Val Thr Glu His Leu Pro Glu Lys Ile Glu Ser Ser Leu Gln Glu 
                245                 250                 255     


Asp Glu Pro Glu Asn Asp Ala Lys Lys Ile Glu Ala Leu Leu Asn Leu 
            260                 265                 270         


Pro Arg Asn Pro Ser Val Ile Asp Lys Gln Asp Lys Asp 
        275                 280                 285 


<210>  4253
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  4253

Met Lys Ile Phe Lys Cys Tyr Phe Lys His Thr Leu Gln Gln Lys Val 
1               5                   10                  15      


Phe Ile Leu Phe Leu Thr Leu Trp Leu Leu Ser Leu Leu Lys Leu Leu 
            20                  25                  30          


Asn Val Arg Arg Leu Phe Pro Gln Lys Asp Ile Tyr Leu Val Glu Tyr 
        35                  40                  45              


Ser Leu Ser Thr Ser Pro Phe Val Arg Asn Arg Tyr Thr His Val Lys 
    50                  55                  60                  


Asp Glu Val Arg Tyr Glu Val Asn Cys Ser Gly Ile Tyr Glu Gln Glu 
65                  70                  75                  80  


Pro Leu Glu Ile Gly Lys Ser Leu Glu Ile Arg Arg Arg Asp Ile Ile 
                85                  90                  95      


Asp Leu Glu Asp Asp Asp Val Val Ala Met Thr Ser Asp Cys Asp Ile 
            100                 105                 110         


Tyr Gln Thr Leu Arg Gly Tyr Ala Gln Lys Leu Val Ser Lys Glu Glu 
        115                 120                 125             


Lys Ser Phe Pro Ile Ala Tyr Ser Leu Val Val His Lys Asp Ala Ile 
    130                 135                 140                 


Met Val Glu Arg Leu Ile His Ala Ile Tyr Asn Gln His Asn Ile Tyr 
145                 150                 155                 160 


Cys Ile His Tyr Asp Arg Lys Ala Pro Asp Thr Phe Lys Val Ala Met 
                165                 170                 175     


Asn Asn Leu Ala Lys Cys Phe Ser Asn Ile Phe Ile Ala Ser Lys Leu 
            180                 185                 190         


Glu Ala Val Glu Tyr Ala His Ile Ser Arg Leu Gln Ala Asp Leu Asn 
        195                 200                 205             


Cys Leu Ser Asp Leu Leu Lys Ser Ser Ile Gln Trp Lys Tyr Val Ile 
    210                 215                 220                 


Asn Leu Cys Gly Gln Asp Phe Pro Leu Lys Ser Asn Phe Glu Leu Val 
225                 230                 235                 240 


Ser Glu Leu Lys Lys Leu Asn Gly Ala Asn Met Leu Glu Thr Val Lys 
                245                 250                 255     


Pro Pro Asn Ser Lys Leu Glu Arg Phe Thr Tyr His His Glu Leu Arg 
            260                 265                 270         


Arg Val Pro Tyr Glu Tyr Val Lys Leu Pro Ile Arg Thr Asn Ile Ser 
        275                 280                 285             


Lys Glu Ala Pro Pro His Asn Ile Gln Ile Phe Val Gly Ser Ala Tyr 
    290                 295                 300                 


Phe Val Leu Ser Gln Ala Phe Val Lys Tyr Ile Phe Asn Asn Ser Ile 
305                 310                 315                 320 


Val Gln Asp Phe Phe Ala Trp Ser Lys Asp Thr Tyr Ser Pro Asp Glu 
                325                 330                 335     


His Phe Trp Ala Thr Leu Ile Arg Val Pro Gly Ile Pro Gly Glu Ile 
            340                 345                 350         


Ser Arg Ser Ala Gln Asp Val Ser Asp Leu Gln Ser Lys Thr Arg Leu 
        355                 360                 365             


Val Lys Trp Asn Tyr Tyr Glu Gly Phe Phe Tyr Pro Ser Cys Thr Gly 
    370                 375                 380                 


Ser His Leu Arg Ser Val Cys Ile Tyr Gly Ala Ala Glu Leu Arg Trp 
385                 390                 395                 400 


Leu Ile Lys Asp Gly His Trp Phe Ala Asn Lys Phe Asp Ser Lys Val 
                405                 410                 415     


Asp Pro Ile Leu Ile Lys Cys Leu Ala Glu Lys Leu Glu Glu Gln Gln 
            420                 425                 430         


Arg Asp Trp Ile Thr Leu Pro Ser Glu Lys Leu Phe Met Asp Arg Asn 
        435                 440                 445             


Leu Thr Thr Thr Ser 
    450             


<210>  4254
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  4254

Met Glu Leu Ile Ser Pro Thr Val Ile Ile Ile Leu Gly Cys Leu Ala 
1               5                   10                  15      


Leu Phe Leu Leu Leu Gln Arg Lys Asn Leu Arg Arg Pro Pro Cys Ile 
            20                  25                  30          


Lys Gly Trp Ile Pro Trp Ile Gly Val Gly Phe Glu Phe Gly Lys Ala 
        35                  40                  45              


Pro Leu Glu Phe Ile Glu Lys Ala Arg Ile Lys Tyr Gly Pro Ile Phe 
    50                  55                  60                  


Thr Val Phe Ala Met Gly Asn Arg Met Thr Phe Val Thr Glu Glu Glu 
65                  70                  75                  80  


Gly Ile Asn Val Phe Leu Lys Ser Lys Lys Val Asp Phe Glu Leu Ala 
                85                  90                  95      


Val Gln Asn Ile Val Tyr Arg Thr Ala Ser Ile Pro Lys Asn Val Phe 
            100                 105                 110         


Leu Ala Leu His Glu Lys Leu Tyr Ile Met Leu Lys Gly Lys Met Gly 
        115                 120                 125             


Thr Val Asn Leu His Gln Phe Thr Gly Gln Leu Thr Glu Glu Leu His 
    130                 135                 140                 


Glu Gln Leu Glu Asn Leu Gly Thr His Gly Thr Met Asp Leu Asn Asn 
145                 150                 155                 160 


Leu Val Arg His Leu Leu Tyr Pro Val Thr Val Asn Met Leu Phe Asn 
                165                 170                 175     


Lys Ser Leu Phe Ser Thr Asn Lys Lys Lys Ile Lys Glu Phe His Gln 
            180                 185                 190         


Tyr Phe Gln Val Tyr Asp Glu Asp Phe Glu Tyr Gly Ser Gln Leu Pro 
        195                 200                 205             


Glu Cys Leu Leu Arg Asn Trp Ser Lys Ser Lys Lys Trp Phe Leu Glu 
    210                 215                 220                 


Leu Phe Glu Lys Asn Ile Pro Asp Ile Lys Ala Cys Lys Ser Ala Lys 
225                 230                 235                 240 


Asp Asn Ser Met Thr Leu Leu Gln Ala Thr Leu Asp Ile Val Glu Thr 
                245                 250                 255     


Glu Thr Ser Lys Glu Asn Ser Pro Asn Tyr Gly Leu Leu Leu Leu Trp 
            260                 265                 270         


Ala Ser Leu Ser Asn Ala Val Pro Val Ala Phe Trp Thr Leu Ala Tyr 
        275                 280                 285             


Val Leu Ser His Pro Asp Ile His Lys Ala Ile Met Glu Gly Ile Ser 
    290                 295                 300                 


Ser Val Phe Gly Lys Ala Gly Lys Asp Lys Ile Lys Val Ser Glu Asp 
305                 310                 315                 320 


Asp Leu Glu Asn Leu Leu Leu Ile Lys Trp Cys Val Leu Glu Thr Ile 
                325                 330                 335     


Arg Leu Lys Ala Pro Gly Val Ile Thr Arg Lys Val Val Lys Pro Val 
            340                 345                 350         


Glu Ile Leu Asn Tyr Ile Ile Pro Ser Gly Asp Leu Leu Met Leu Ser 
        355                 360                 365             


Pro Phe Trp Leu His Arg Asn Pro Lys Tyr Phe Pro Glu Pro Glu Leu 
    370                 375                 380                 


Phe Lys Pro Glu Arg Trp Lys Lys Ala Asn Leu Glu Lys His Ser Phe 
385                 390                 395                 400 


Leu Asp Cys Phe Met Ala Phe Gly Ser Gly Lys Phe Gln Cys Pro Ala 
                405                 410                 415     


Arg Trp Phe Ala Leu Leu Glu Val Gln Met Cys Ile Ile Leu Ile Leu 
            420                 425                 430         


Tyr Lys Tyr Asp Cys Ser Leu Leu Asp Pro Leu Pro Lys Gln Ser Tyr 
        435                 440                 445             


Leu His Leu Val Gly Val Pro Gln Pro Glu Gly Gln Cys Arg Ile Glu 
    450                 455                 460                 


Tyr Lys Gln Arg Ile 
465                 


<210>  4255
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  4255

Met Thr Leu Arg Pro Ser Leu Leu Pro Leu His Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ala Ala Val Cys Arg Ala Glu Ala Gly Leu Glu Thr Glu 
            20                  25                  30          


Ser Pro Val Arg Thr Leu Gln Val Glu Thr Leu Val Glu Pro Pro Glu 
        35                  40                  45              


Pro Cys Ala Glu Pro Ala Ala Phe Gly Asp Thr Leu His Ile His Tyr 
    50                  55                  60                  


Thr Gly Ser Leu Val Asp Gly Arg Ile Ile Asp Thr Ser Leu Thr Arg 
65                  70                  75                  80  


Asp Pro Leu Val Ile Glu Leu Gly Gln Lys Gln Val Ile Pro Gly Leu 
                85                  90                  95      


Glu Gln Ser Leu Leu Asp Met Cys Val Gly Glu Lys Arg Arg Ala Ile 
            100                 105                 110         


Ile Pro Ser His Leu Ala Tyr Gly Lys Arg Gly Phe Pro Pro Ser Val 
        115                 120                 125             


Pro Ala Asp Ala Val Val Gln Tyr Asp Val Glu Leu Ile Ala Leu Ile 
    130                 135                 140                 


Arg Ala Asn Tyr Trp Leu Lys Leu Val Lys Gly Ile Leu Pro Leu Val 
145                 150                 155                 160 


Gly Met Ala Met Val Pro Ala Leu Leu Gly Leu Ile Gly Tyr His Leu 
                165                 170                 175     


Tyr Arg Lys Ala Asn Arg Pro Lys Val Ser Lys Lys Lys Leu Lys Glu 
            180                 185                 190         


Glu Lys Arg Asn Lys Ser Lys Lys Lys 
        195                 200     


<210>  4256
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  4256

Met Met Leu Ile Pro Thr His His Phe Arg Asn Ile Glu Arg Lys Pro 
1               5                   10                  15      


Glu Tyr Leu Gln Pro Glu Lys Cys Val Pro Pro Pro Tyr Pro Gly Pro 
            20                  25                  30          


Val Gly Thr Met Trp Phe Ile Arg Asp Gly Cys Gly Ile Ala Cys Ala 
        35                  40                  45              


Ile Val Thr Trp Phe Leu Val Leu Tyr Ala Glu Phe Val Val Leu Phe 
    50                  55                  60                  


Val Met Leu Ile Pro Ser Arg Asp Tyr Val Tyr Ser Ile Ile Asn Gly 
65                  70                  75                  80  


Ile Val Phe Asn Leu Leu Ala Phe Leu Ala Leu Ala Ser His Cys Arg 
                85                  90                  95      


Ala Met Leu Thr Asp Pro Gly Ala Val Pro Lys Gly Asn Ala Thr Lys 
            100                 105                 110         


Glu Phe Ile Glu Ser Leu Gln Leu Lys Pro Gly Gln Val Val Tyr Lys 
        115                 120                 125             


Cys Pro Lys Cys Cys Ser Ile Lys Pro Asp Arg Ala His His Cys Ser 
    130                 135                 140                 


Val Cys Lys Arg Cys Ile Arg Lys Met Asp His His Cys Pro Trp Val 
145                 150                 155                 160 


Asn Asn Cys Val Gly Glu Asn Asn Gln Lys Tyr Phe Val Leu Phe Thr 
                165                 170                 175     


Met Tyr Ile Ala Leu Ile Ser Leu His Ala Leu Ile Met Val Gly Phe 
            180                 185                 190         


His Phe Leu His Cys Phe Glu Glu Asp Trp Thr Thr Tyr Gly Leu Asn 
        195                 200                 205             


Arg Glu Glu Met Ala Glu Thr Gly Ile Ser Leu His Glu Lys Met Gln 
    210                 215                 220                 


Pro Leu Asn Phe Ser Ser Thr Glu Cys Ser Ser Phe Ser Pro Pro Thr 
225                 230                 235                 240 


Thr Val Ile Leu Leu Ile Leu Leu Cys Phe Glu Gly Leu Leu Phe Leu 
                245                 250                 255     


Ile Phe Thr Ser Val Met Phe Gly Thr Gln Val His Ser Ile Cys Thr 
            260                 265                 270         


Asp Glu Thr Gly Ile Glu Gln Leu Lys Lys Glu Glu Arg Arg Trp Ala 
        275                 280                 285             


Lys Lys Thr Lys Trp Met Asn Met Lys Ala Val Phe Gly His Pro Phe 
    290                 295                 300                 


Ser Leu Gly Trp Ala Ser Pro Phe Ala Thr Pro Asp Gln Gly Lys Ala 
305                 310                 315                 320 


Asp Pro Tyr Gln Tyr Val Val 
                325         


<210>  4257
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  4257

Met Lys Arg Gln Asn Val Arg Thr Leu Ser Leu Ile Val Cys Thr Phe 
1               5                   10                  15      


Thr Tyr Leu Leu Val Gly Ala Ala Val Phe Asp Ala Leu Glu Ser Asp 
            20                  25                  30          


His Glu Met Arg Glu Glu Glu Lys Leu Lys Ala Glu Glu Ile Arg Ile 
        35                  40                  45              


Lys Gly Lys Tyr Asn Ile Ser Ser Glu Asp Tyr Arg Gln Leu Glu Leu 
    50                  55                  60                  


Val Ile Leu Gln Ser Glu Pro His Arg Ala Gly Val Gln Trp Lys Phe 
65                  70                  75                  80  


Ala Gly Ser Phe Tyr Phe Ala Ile Thr Val Ile Thr Thr Ile Gly Tyr 
                85                  90                  95      


Gly His Ala Ala Pro Gly Thr Asp Ala Gly Lys Ala Phe Cys Met Phe 
            100                 105                 110         


Tyr Ala Val Leu Gly Ile Pro Leu Thr Leu Val Met Phe Gln Ser Leu 
        115                 120                 125             


Gly Glu Arg Met Asn Thr Phe Val Arg Tyr Leu Leu Lys Arg Ile Lys 
    130                 135                 140                 


Lys Cys Cys Gly Met Arg Asn Thr Asp Val Ser Met Glu Asn Met Val 
145                 150                 155                 160 


Thr Val Gly Phe Phe Ser Cys Met Gly Thr Leu Cys Ile Gly Ala Ala 
                165                 170                 175     


Ala Phe Ser Gln Cys Glu Glu Trp Ser Phe Phe His Ala Tyr Tyr Tyr 
            180                 185                 190         


Cys Phe Ile Thr Leu Thr Thr Ile Gly Phe Gly Asp Tyr Val Ala Leu 
        195                 200                 205             


Gln Thr Lys Gly Ala Leu Gln Lys Lys Pro Leu Tyr Val Ala Phe Ser 
    210                 215                 220                 


Phe Met Tyr Ile Leu Val Gly Leu Thr Val Ile Gly Ala Phe Leu Asn 
225                 230                 235                 240 


Leu Val Val Leu Arg Phe Leu Thr Met Asn Ser Glu Asp Glu Arg Arg 
                245                 250                 255     


Asp Ala Glu Glu Arg Ala Ser Leu Ala Gly Asn Arg Asn Ser Met Val 
            260                 265                 270         


Ile His Ile Pro Glu Glu Pro Arg Pro Ser Arg Pro Arg Tyr Lys Ala 
        275                 280                 285             


Asp Val Pro Asp Leu Gln Ser Val Cys Ser Cys Thr Cys Tyr Arg Ser 
    290                 295                 300                 


Gln Asp Tyr Gly Gly Arg Ser Val Ala Pro Gln Asn Ser Phe Ser Ala 
305                 310                 315                 320 


Lys Leu Ala Pro His Tyr Phe His Ser Ile Ser Tyr Lys Ile Glu Glu 
                325                 330                 335     


Ile Ser Pro Ser Thr Leu Lys Asn Ser Leu Phe Pro Ser Pro Ile Ser 
            340                 345                 350         


Ser Ile Ser Pro Gly Leu His Ser Phe Thr Asp His Gln Arg Leu Met 
        355                 360                 365             


Lys Arg Arg Lys Ser Val 
    370                 


<210>  4258
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  4258

Met Gly Thr Glu Ala Thr Glu Gln Val Ser Trp Gly His Tyr Ser Gly 
1               5                   10                  15      


Asp Glu Glu Asp Ala Tyr Ser Ala Glu Pro Leu Pro Glu Leu Cys Tyr 
            20                  25                  30          


Lys Ala Asp Val Gln Ala Phe Ser Arg Ala Phe Gln Pro Ser Val Ser 
        35                  40                  45              


Leu Thr Val Ala Ala Leu Gly Leu Ala Gly Asn Gly Leu Val Leu Ala 
    50                  55                  60                  


Thr His Leu Ala Ala Arg Arg Ala Ala Arg Ser Pro Thr Ser Ala His 
65                  70                  75                  80  


Leu Leu Gln Leu Ala Leu Ala Asp Leu Leu Leu Ala Leu Thr Leu Pro 
                85                  90                  95      


Phe Ala Ala Ala Gly Ala Leu Gln Gly Trp Ser Leu Gly Ser Ala Thr 
            100                 105                 110         


Cys Arg Thr Ile Ser Gly Leu Tyr Ser Ala Ser Phe His Ala Gly Phe 
        115                 120                 125             


Leu Phe Leu Ala Cys Ile Ser Ala Asp Arg Tyr Val Ala Ile Ala Arg 
    130                 135                 140                 


Ala Leu Pro Ala Gly Pro Arg Pro Ser Thr Pro Gly Arg Ala His Leu 
145                 150                 155                 160 


Val Ser Val Ile Val Trp Leu Leu Ser Leu Leu Leu Ala Leu Pro Ala 
                165                 170                 175     


Leu Leu Phe Ser Gln Asp Gly Gln Arg Glu Gly Gln Arg Arg Cys Arg 
            180                 185                 190         


Leu Ile Phe Pro Glu Gly Leu Thr Gln Thr Val Lys Gly Ala Ser Ala 
        195                 200                 205             


Val Ala Gln Val Ala Leu Gly Phe Ala Leu Pro Leu Gly Val Met Val 
    210                 215                 220                 


Ala Cys Tyr Ala Leu Leu Gly Arg Thr Leu Leu Ala Ala Arg Gly Pro 
225                 230                 235                 240 


Glu Arg Arg Arg Ala Leu Arg Val Val Val Ala Leu Val Ala Ala Phe 
                245                 250                 255     


Val Val Leu Gln Leu Pro Tyr Ser Leu Ala Leu Leu Leu Asp Thr Ala 
            260                 265                 270         


Asp Leu Leu Ala Ala Arg Glu Arg Ser Cys Pro Ala Ser Lys Arg Lys 
        275                 280                 285             


Asp Val Ala Leu Leu Val Thr Ser Gly Leu Ala Leu Ala Arg Cys Gly 
    290                 295                 300                 


Leu Asn Pro Val Leu Tyr Ala Phe Leu Gly Leu Arg Phe Arg Gln Asp 
305                 310                 315                 320 


Leu Arg Arg Leu Leu Arg Gly Gly Ser Cys Pro Ser Gly Pro Gln Pro 
                325                 330                 335     


Arg Arg Gly Cys Pro Arg Arg Pro Arg Leu Ser Ser Cys Ser Ala Pro 
            340                 345                 350         


Thr Glu Thr His Ser Leu Ser Trp Asp Asn 
        355                 360         


<210>  4259
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  4259

Met Val Ser Trp Ile Ile Ser Arg Leu Val Val Leu Ile Phe Gly Thr 
1               5                   10                  15      


Leu Tyr Pro Ala Tyr Ser Ser Tyr Lys Ala Val Lys Thr Lys Asn Val 
            20                  25                  30          


Lys Glu Tyr Val Lys Trp Met Met Tyr Trp Ile Val Phe Ala Phe Phe 
        35                  40                  45              


Thr Thr Ala Glu Thr Leu Thr Asp Ile Val Leu Ser Trp Phe Pro Phe 
    50                  55                  60                  


Tyr Phe Glu Leu Lys Ile Ala Phe Val Ile Trp Leu Leu Ser Pro Tyr 
65                  70                  75                  80  


Thr Lys Gly Ser Ser Val Leu Tyr Arg Lys Phe Val His Pro Thr Leu 
                85                  90                  95      


Ser Asn Lys Glu Lys Glu Ile Asp Glu Tyr Ile Thr Gln Ala Arg Asp 
            100                 105                 110         


Lys Ser Tyr Glu Thr Met Met Arg Val Gly Lys Arg Gly Leu Asn Leu 
        115                 120                 125             


Ala Ala Asn Ala Ala Val Thr Ala Ala Ala Lys Gly Val Leu Ser Glu 
    130                 135                 140                 


Lys Leu Arg Ser Phe Ser Met Gln Asp Leu Thr Leu Ile Arg Asp Glu 
145                 150                 155                 160 


Asp Ala Leu Pro Leu Gln Arg Pro Asp Gly Arg Leu Arg Pro Ser Pro 
                165                 170                 175     


Gly Ser Leu Leu Asp Thr Ile Glu Asp Leu Gly Asp Asp Pro Ala Leu 
            180                 185                 190         


Ser Leu Arg Ser Ser Thr Asn Pro Ala Asp Ser Arg Thr Glu Ala Ser 
        195                 200                 205             


Glu Asp Asp Met Gly Asp Lys Ala Pro Lys Arg Ala Lys Pro Ile Lys 
    210                 215                 220                 


Lys Ala Pro Lys Ala Glu Pro Leu Ala Ser Lys Thr Leu Lys Thr Arg 
225                 230                 235                 240 


Pro Lys Lys Lys Thr Ser Gly Gly Gly Asp Ser Ala 
                245                 250         


<210>  4260
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  4260

Met Gly Tyr Ala Arg Lys Val Gly Trp Val Thr Ala Gly Leu Val Ile 
1               5                   10                  15      


Gly Ala Gly Ala Cys Tyr Cys Ile Tyr Arg Leu Thr Arg Gly Arg Lys 
            20                  25                  30          


Gln Asn Lys Glu Lys Met Ala Glu Gly Gly Ser Gly Asp Val Asp Asp 
        35                  40                  45              


Ala Gly Asp Cys Ser Gly Ala Arg Tyr Asn Asp Trp Ser Asp Asp Asp 
    50                  55                  60                  


Asp Asp Ser Asn Glu Ser Lys Ser Ile Val Trp Tyr Pro Pro Trp Ala 
65                  70                  75                  80  


Arg Ile Gly Thr Glu Ala Gly Thr Arg Ala Arg Ala Arg Ala Arg Ala 
                85                  90                  95      


Arg Ala Thr Arg Ala Arg Arg Ala Val Gln Lys Arg Ala Ser Pro Asn 
            100                 105                 110         


Ser Asp Asp Thr Val Leu Ser Pro Gln Glu Leu Gln Lys Val Leu Cys 
        115                 120                 125             


Leu Val Glu Met Ser Glu Lys Pro Tyr Ile Leu Glu Ala Ala Leu Ile 
    130                 135                 140                 


Ala Leu Gly Asn Asn Ala Ala Tyr Ala Phe Asn Arg Asp Ile Ile Arg 
145                 150                 155                 160 


Asp Leu Gly Gly Leu Pro Ile Val Ala Lys Ile Leu Asn Thr Arg Asp 
                165                 170                 175     


Pro Ile Val Lys Glu Lys Ala Leu Ile Val Leu Asn Asn Leu Ser Val 
            180                 185                 190         


Asn Ala Glu Asn Gln Arg Arg Leu Lys Val Tyr Met Asn Gln Val Cys 
        195                 200                 205             


Asp Asp Thr Ile Thr Ser Arg Leu Asn Ser Ser Val Gln Leu Ala Gly 
    210                 215                 220                 


Leu Arg Leu Leu Thr Asn Met Thr Val Thr Asn Glu Tyr Gln His Met 
225                 230                 235                 240 


Leu Ala Asn Ser Ile Ser Asp Phe Phe Arg Leu Phe Ser Ala Gly Asn 
                245                 250                 255     


Glu Glu Thr Lys Leu Gln Val Leu Lys Leu Leu Leu Asn Leu Ala Glu 
            260                 265                 270         


Asn Pro Ala Met Thr Arg Glu Leu Leu Arg Ala Gln Val Pro Ser Ser 
        275                 280                 285             


Leu Gly Ser Leu Phe Asn Lys Lys Glu Asn Lys Glu Val Ile Leu Lys 
    290                 295                 300                 


Leu Leu Val Ile Phe Glu Asn Ile Asn Asp Asn Phe Lys Trp Glu Glu 
305                 310                 315                 320 


Asn Glu Pro Thr Gln Asn Gln Phe Gly Glu Gly Ser Leu Phe Phe Phe 
                325                 330                 335     


Leu Lys Glu Phe Gln Val Cys Ala Asp Lys Val Leu Gly Ile Glu Ser 
            340                 345                 350         


His His Asp Phe Leu Val Lys Val Lys Val Gly Lys Phe Met Ala Lys 
        355                 360                 365             


Leu Ala Glu His Met Phe Pro Lys Ser Gln Glu 
    370                 375                 


<210>  4261
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  4261

Met Gly Arg Thr Arg Glu Ala Gly Cys Val Ala Ala Gly Val Val Ile 
1               5                   10                  15      


Gly Ala Gly Ala Cys Tyr Cys Val Tyr Arg Leu Ala Trp Gly Arg Asp 
            20                  25                  30          


Glu Asn Glu Lys Ile Trp Asp Glu Asp Glu Glu Ser Thr Asp Thr Ser 
        35                  40                  45              


Glu Ile Gly Val Glu Thr Val Lys Gly Ala Lys Thr Asn Ala Gly Ala 
    50                  55                  60                  


Gly Ser Gly Ala Lys Leu Gln Gly Asp Ser Glu Val Lys Pro Glu Val 
65                  70                  75                  80  


Ser Leu Gly Leu Glu Asp Cys Pro Gly Val Lys Glu Lys Ala His Ser 
                85                  90                  95      


Gly Ser His Ser Gly Gly Gly Leu Glu Ala Lys Ala Lys Ala Leu Phe 
            100                 105                 110         


Asn Thr Leu Lys Glu Gln Ala Ser Ala Lys Ala Gly Lys Gly Ala Arg 
        115                 120                 125             


Val Gly Thr Ile Ser Gly Asn Arg Thr Leu Ala Pro Ser Leu Pro Cys 
    130                 135                 140                 


Pro Gly Gly Arg Gly Gly Gly Cys His Pro Thr Arg Ser Gly Ser Arg 
145                 150                 155                 160 


Ala Gly Gly Arg Ala Ser Gly Lys Ser Lys Gly Lys Ala Arg Ser Lys 
                165                 170                 175     


Ser Thr Arg Ala Pro Ala Thr Thr Trp Pro Val Arg Arg Gly Lys Phe 
            180                 185                 190         


Asn Phe Pro Tyr Lys Ile Asp Asp Ile Leu Ser Ala Pro Asp Leu Gln 
        195                 200                 205             


Lys Val Leu Asn Ile Leu Glu Arg Thr Asn Asp Pro Phe Ile Gln Glu 
    210                 215                 220                 


Val Ala Leu Val Thr Leu Gly Asn Asn Ala Ala Tyr Ser Phe Asn Gln 
225                 230                 235                 240 


Asn Ala Ile Arg Glu Leu Gly Gly Val Pro Ile Ile Ala Lys Leu Ile 
                245                 250                 255     


Lys Thr Lys Asp Pro Ile Ile Arg Glu Lys Thr Tyr Asn Ala Leu Asn 
            260                 265                 270         


Asn Leu Ser Val Asn Ala Glu Asn Gln Gly Lys Ile Lys Thr Tyr Ile 
        275                 280                 285             


Ser Gln Val Cys Asp Asp Thr Met Val Cys Arg Leu Asp Ser Ala Val 
    290                 295                 300                 


Gln Met Ala Gly Leu Arg Leu Leu Thr Asn Met Thr Val Thr Asn His 
305                 310                 315                 320 


Tyr Gln His Leu Leu Ser Tyr Ser Phe Pro Asp Phe Phe Ala Leu Leu 
                325                 330                 335     


Phe Leu Gly Asn His Phe Thr Lys Ile Gln Ile Met Lys Leu Ile Ile 
            340                 345                 350         


Asn Phe Thr Glu Asn Pro Ala Met Thr Arg Glu Leu Val Ser Cys Lys 
        355                 360                 365             


Val Pro Ser Glu Leu Ile Ser Leu Phe Asn Lys Glu Trp Asp Arg Glu 
    370                 375                 380                 


Ile Leu Leu Asn Ile Leu Thr Leu Phe Glu Asn Ile Asn Asp Asn Ile 
385                 390                 395                 400 


Lys Asn Glu Gly Leu Ala Ser Ser Arg Lys Glu Phe Ser Arg Ser Ser 
                405                 410                 415     


Leu Phe Phe Leu Phe Lys Glu Ser Gly Val Cys Val Lys Lys Ile Lys 
            420                 425                 430         


Ala Leu Ala Asn His Asn Asp Leu Val Val Lys Val Lys Val Leu Lys 
        435                 440                 445             


Val Leu Thr Lys Leu 
    450             


<210>  4262
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  4262

Met Ala Ser Asp Pro Ile Phe Thr Leu Ala Pro Pro Leu His Cys His 
1               5                   10                  15      


Tyr Gly Ala Phe Pro Pro Asn Ala Ser Gly Trp Glu Gln Pro Pro Asn 
            20                  25                  30          


Ala Ser Gly Val Ser Val Ala Ser Ala Ala Leu Ala Ala Ser Ala Ala 
        35                  40                  45              


Ser Arg Val Ala Thr Ser Thr Asp Pro Ser Cys Ser Gly Phe Ala Pro 
    50                  55                  60                  


Pro Asp Phe Asn His Cys Leu Lys Asp Trp Asp Tyr Asn Gly Leu Pro 
65                  70                  75                  80  


Val Leu Thr Thr Asn Ala Ile Gly Gln Trp Asp Leu Val Cys Asp Leu 
                85                  90                  95      


Gly Trp Gln Val Ile Leu Glu Gln Ile Leu Phe Ile Leu Gly Phe Ala 
            100                 105                 110         


Ser Gly Tyr Leu Phe Leu Gly Tyr Pro Ala Asp Arg Phe Gly Arg Arg 
        115                 120                 125             


Gly Ile Val Leu Leu Thr Leu Gly Leu Val Gly Pro Cys Gly Val Gly 
    130                 135                 140                 


Gly Ala Ala Ala Gly Ser Ser Thr Gly Val Met Ala Leu Arg Phe Leu 
145                 150                 155                 160 


Leu Gly Phe Leu Leu Ala Gly Val Asp Leu Gly Val Tyr Leu Met Arg 
                165                 170                 175     


Leu Glu Leu Cys Asp Pro Thr Gln Arg Leu Arg Val Ala Leu Ala Gly 
            180                 185                 190         


Glu Leu Val Gly Val Gly Gly His Phe Leu Phe Leu Gly Leu Ala Leu 
        195                 200                 205             


Val Ser Lys Asp Trp Arg Phe Leu Gln Arg Met Ile Thr Ala Pro Cys 
    210                 215                 220                 


Ile Leu Phe Leu Phe Tyr Gly Trp Pro Gly Leu Phe Leu Glu Ser Ala 
225                 230                 235                 240 


Arg Trp Leu Ile Val Lys Arg Gln Ile Glu Glu Ala Gln Ser Val Leu 
                245                 250                 255     


Arg Ile Leu Ala Glu Arg Asn Arg Pro His Gly Gln Met Leu Gly Glu 
            260                 265                 270         


Glu Ala Gln Glu Ala Leu Gln Asp Leu Glu Asn Thr Cys Pro Leu Pro 
        275                 280                 285             


Ala Thr Ser Ser Phe Ser Phe Ala Ser Leu Leu Asn Tyr Arg Asn Ile 
    290                 295                 300                 


Trp Lys Asn Leu Leu Ile Leu Gly Phe Thr Asn Phe Ile Ala His Ala 
305                 310                 315                 320 


Ile Arg His Cys Tyr Gln Pro Val Gly Gly Gly Gly Ser Pro Ser Asp 
                325                 330                 335     


Phe Tyr Leu Cys Ser Leu Leu Ala Ser Gly Thr Ala Ala Leu Ala Cys 
            340                 345                 350         


Val Phe Leu Gly Val Thr Val Asp Arg Phe Gly Arg Arg Gly Ile Leu 
        355                 360                 365             


Leu Leu Ser Met Thr Leu Thr Gly Ile Ala Ser Leu Val Leu Leu Gly 
    370                 375                 380                 


Leu Trp Asp Tyr Leu Asn Glu Ala Ala Ile Thr Thr Phe Ser Val Leu 
385                 390                 395                 400 


Gly Leu Phe Ser Ser Gln Ala Ala Ala Ile Leu Ser Thr Leu Leu Ala 
                405                 410                 415     


Ala Glu Val Ile Pro Thr Thr Val Arg Gly Arg Gly Leu Gly Leu Ile 
            420                 425                 430         


Met Ala Leu Gly Ala Leu Gly Gly Leu Ser Gly Pro Ala Gln Arg Leu 
        435                 440                 445             


His Met Gly His Gly Ala Phe Leu Gln His Val Val Leu Ala Ala Cys 
    450                 455                 460                 


Ala Leu Leu Cys Ile Leu Ser Ile Met Leu Leu Pro Glu Thr Lys Arg 
465                 470                 475                 480 


Lys Leu Leu Pro Glu Val Leu Arg Asp Gly Glu Leu Cys Arg Arg Pro 
                485                 490                 495     


Ser Leu Leu Arg Gln Pro Pro Pro Thr Arg Cys Asp His Val Pro Leu 
            500                 505                 510         


Leu Ala Thr Pro Asn Pro Ala Leu 
        515                 520 


<210>  4263
<211>  519
<212>  PRT
<213>  Homo sapiens

<400>  4263

Met Thr Cys Pro Asp Lys Pro Gly Gln Leu Ile Asn Trp Phe Ile Cys 
1               5                   10                  15      


Ser Leu Cys Val Pro Arg Val Arg Lys Leu Trp Ser Ser Arg Arg Pro 
            20                  25                  30          


Arg Thr Arg Arg Asn Leu Leu Leu Gly Thr Ala Cys Ala Ile Tyr Leu 
        35                  40                  45              


Gly Phe Leu Val Ser Gln Val Gly Arg Ala Ser Leu Gln His Gly Gln 
    50                  55                  60                  


Ala Ala Glu Lys Gly Pro His Arg Ser Arg Asp Thr Ala Glu Pro Ser 
65                  70                  75                  80  


Phe Pro Glu Ile Pro Leu Asp Gly Thr Leu Ala Pro Pro Glu Ser Gln 
                85                  90                  95      


Gly Asn Gly Ser Thr Leu Gln Pro Asn Val Val Tyr Ile Thr Leu Arg 
            100                 105                 110         


Ser Lys Arg Ser Lys Pro Ala Asn Ile Arg Gly Thr Val Lys Pro Lys 
        115                 120                 125             


Arg Arg Lys Lys His Ala Val Ala Ser Ala Ala Pro Gly Gln Glu Ala 
    130                 135                 140                 


Leu Val Gly Pro Ser Leu Gln Pro Gln Glu Ala Ala Arg Glu Ala Asp 
145                 150                 155                 160 


Ala Val Ala Pro Gly Tyr Ala Gln Gly Ala Asn Leu Val Lys Ile Gly 
                165                 170                 175     


Glu Arg Pro Trp Arg Leu Val Arg Gly Pro Gly Val Arg Ala Gly Gly 
            180                 185                 190         


Pro Asp Phe Leu Gln Pro Ser Ser Arg Glu Ser Asn Ile Arg Ile Tyr 
        195                 200                 205             


Ser Glu Ser Ala Pro Ser Trp Leu Ser Lys Asp Asp Ile Arg Arg Met 
    210                 215                 220                 


Arg Leu Leu Ala Asp Ser Ala Val Ala Gly Leu Arg Pro Val Ser Ser 
225                 230                 235                 240 


Arg Ser Gly Ala Arg Leu Leu Val Leu Glu Gly Gly Ala Pro Gly Ala 
                245                 250                 255     


Val Leu Arg Cys Gly Pro Ser Pro Cys Gly Leu Leu Lys Gln Pro Leu 
            260                 265                 270         


Asp Met Ser Glu Val Phe Ala Phe His Leu Asp Arg Ile Leu Gly Leu 
        275                 280                 285             


Asn Arg Thr Leu Pro Ser Val Ser Arg Lys Ala Glu Phe Ile Gln Asp 
    290                 295                 300                 


Gly Arg Pro Cys Pro Ile Ile Leu Trp Asp Ala Ser Leu Ser Ser Ala 
305                 310                 315                 320 


Ser Asn Asp Thr His Ser Ser Val Lys Leu Thr Trp Gly Thr Tyr Gln 
                325                 330                 335     


Gln Leu Leu Lys Gln Lys Cys Trp Gln Asn Gly Arg Val Pro Lys Pro 
            340                 345                 350         


Glu Ser Gly Cys Thr Glu Ile His His His Glu Trp Ser Lys Met Ala 
        355                 360                 365             


Leu Phe Asp Phe Leu Leu Gln Ile Tyr Asn Arg Leu Asp Thr Asn Cys 
    370                 375                 380                 


Cys Gly Phe Arg Pro Arg Lys Glu Asp Ala Cys Val Gln Asn Gly Leu 
385                 390                 395                 400 


Arg Pro Lys Cys Asp Asp Gln Gly Ser Ala Ala Leu Ala His Ile Ile 
                405                 410                 415     


Gln Arg Lys His Asp Pro Arg His Leu Val Phe Ile Asp Asn Lys Gly 
            420                 425                 430         


Phe Phe Asp Arg Ser Glu Asp Asn Leu Asn Phe Lys Leu Leu Glu Gly 
        435                 440                 445             


Ile Lys Glu Phe Pro Ala Ser Ala Val Ser Val Leu Lys Ser Gln His 
    450                 455                 460                 


Leu Arg Gln Lys Leu Leu Gln Ser Leu Phe Leu Asp Lys Val Tyr Trp 
465                 470                 475                 480 


Glu Ser Gln Gly Gly Arg Gln Gly Ile Glu Lys Leu Ile Asp Val Ile 
                485                 490                 495     


Glu His Arg Ala Lys Ile Leu Ile Thr Tyr Ile Asn Ala His Gly Val 
            500                 505                 510         


Lys Val Leu Pro Met Asn Glu 
        515                 


<210>  4264
<211>  602
<212>  PRT
<213>  Homo sapiens

<400>  4264

Met Asp Ser Arg Val Ser Gly Thr Thr Ser Asn Gly Glu Thr Lys Pro 
1               5                   10                  15      


Val Tyr Pro Val Met Glu Lys Lys Glu Glu Asp Gly Thr Leu Glu Arg 
            20                  25                  30          


Gly His Trp Asn Asn Lys Met Glu Phe Val Leu Ser Val Ala Gly Glu 
        35                  40                  45              


Ile Ile Gly Leu Gly Asn Val Trp Arg Phe Pro Tyr Leu Cys Tyr Lys 
    50                  55                  60                  


Asn Gly Gly Gly Ala Phe Phe Ile Pro Tyr Leu Val Phe Leu Phe Thr 
65                  70                  75                  80  


Cys Gly Ile Pro Val Phe Leu Leu Glu Thr Ala Leu Gly Gln Tyr Thr 
                85                  90                  95      


Ser Gln Gly Gly Val Thr Ala Trp Arg Lys Ile Cys Pro Ile Phe Glu 
            100                 105                 110         


Gly Ile Gly Tyr Ala Ser Gln Met Ile Val Ile Leu Leu Asn Val Tyr 
        115                 120                 125             


Tyr Ile Ile Val Leu Ala Trp Ala Leu Phe Tyr Leu Phe Ser Ser Phe 
    130                 135                 140                 


Thr Ile Asp Leu Pro Trp Gly Gly Cys Tyr His Glu Trp Asn Thr Glu 
145                 150                 155                 160 


His Cys Met Glu Phe Gln Lys Thr Asn Gly Ser Leu Asn Gly Thr Ser 
                165                 170                 175     


Glu Asn Ala Thr Ser Pro Val Ile Glu Phe Trp Glu Arg Arg Val Leu 
            180                 185                 190         


Lys Ile Ser Asp Gly Ile Gln His Leu Gly Ala Leu Arg Trp Glu Leu 
        195                 200                 205             


Ala Leu Cys Leu Leu Leu Ala Trp Val Ile Cys Tyr Phe Cys Ile Trp 
    210                 215                 220                 


Lys Gly Val Lys Ser Thr Gly Lys Val Val Tyr Phe Thr Ala Thr Phe 
225                 230                 235                 240 


Pro Tyr Leu Met Leu Val Val Leu Leu Ile Arg Gly Val Thr Leu Pro 
                245                 250                 255     


Gly Ala Ala Gln Gly Ile Gln Phe Tyr Leu Tyr Pro Asn Leu Thr Arg 
            260                 265                 270         


Leu Trp Asp Pro Gln Val Trp Met Asp Ala Gly Thr Gln Ile Phe Phe 
        275                 280                 285             


Ser Phe Ala Ile Cys Leu Gly Cys Leu Thr Ala Leu Gly Ser Tyr Asn 
    290                 295                 300                 


Lys Tyr His Asn Asn Cys Tyr Arg Asp Cys Ile Ala Leu Cys Phe Leu 
305                 310                 315                 320 


Asn Ser Gly Thr Ser Phe Val Ala Gly Phe Ala Ile Phe Ser Ile Leu 
                325                 330                 335     


Gly Phe Met Ser Gln Glu Gln Gly Val Pro Ile Ser Glu Val Ala Glu 
            340                 345                 350         


Ser Gly Pro Gly Leu Ala Phe Ile Ala Tyr Pro Arg Ala Val Val Met 
        355                 360                 365             


Leu Pro Phe Ser Pro Leu Trp Ala Cys Cys Phe Phe Phe Met Val Val 
    370                 375                 380                 


Leu Leu Gly Leu Asp Ser Gln Phe Val Cys Val Glu Ser Leu Val Thr 
385                 390                 395                 400 


Ala Leu Val Asp Met Tyr Pro His Val Phe Arg Lys Lys Asn Arg Arg 
                405                 410                 415     


Glu Val Leu Ile Leu Gly Val Ser Val Val Ser Phe Leu Val Gly Leu 
            420                 425                 430         


Ile Met Leu Thr Glu Gly Gly Met Tyr Val Phe Gln Leu Phe Asp Tyr 
        435                 440                 445             


Tyr Ala Ala Ser Gly Met Cys Leu Leu Phe Val Ala Ile Phe Glu Ser 
    450                 455                 460                 


Leu Cys Val Ala Trp Val Tyr Gly Ala Lys Arg Phe Tyr Asp Asn Ile 
465                 470                 475                 480 


Glu Asp Met Ile Gly Tyr Arg Pro Trp Pro Leu Ile Lys Tyr Cys Trp 
                485                 490                 495     


Leu Phe Leu Thr Pro Ala Val Cys Thr Ala Thr Phe Leu Phe Ser Leu 
            500                 505                 510         


Ile Lys Tyr Thr Pro Leu Thr Tyr Asn Lys Lys Tyr Thr Tyr Pro Trp 
        515                 520                 525             


Trp Gly Asp Ala Leu Gly Trp Leu Leu Ala Leu Ser Ser Met Val Cys 
    530                 535                 540                 


Ile Pro Ala Trp Ser Leu Tyr Arg Leu Gly Thr Leu Lys Gly Pro Phe 
545                 550                 555                 560 


Arg Glu Arg Ile Arg Gln Leu Met Cys Pro Ala Glu Asp Leu Pro Gln 
                565                 570                 575     


Arg Asn Pro Ala Gly Pro Ser Ala Pro Ala Thr Pro Arg Thr Ser Leu 
            580                 585                 590         


Leu Arg Leu Thr Glu Leu Glu Ser His Cys 
        595                 600         


<210>  4265
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  4265

Met Trp Leu Trp Glu Asp Gln Gly Gly Leu Leu Gly Pro Phe Ser Phe 
1               5                   10                  15      


Leu Leu Leu Val Leu Leu Leu Val Thr Arg Ser Pro Val Asn Ala Cys 
            20                  25                  30          


Leu Leu Thr Gly Ser Leu Phe Val Leu Leu Arg Val Phe Ser Phe Glu 
        35                  40                  45              


Pro Val Pro Ser Cys Arg Ala Leu Gln Val Leu Lys Pro Arg Asp Arg 
    50                  55                  60                  


Ile Ser Ala Ile Ala His Arg Gly Gly Ser His Asp Ala Pro Glu Asn 
65                  70                  75                  80  


Thr Leu Ala Ala Ile Arg Gln Ala Ala Lys Asn Gly Ala Thr Gly Val 
                85                  90                  95      


Glu Leu Asp Ile Glu Phe Thr Ser Asp Gly Ile Pro Val Leu Met His 
            100                 105                 110         


Asp Asn Thr Val Asp Arg Thr Thr Asp Gly Thr Gly Arg Leu Cys Asp 
        115                 120                 125             


Leu Thr Phe Glu Gln Ile Arg Lys Leu Asn Pro Ala Ala Asn His Arg 
    130                 135                 140                 


Leu Arg Asn Asp Phe Pro Asp Glu Lys Ile Pro Thr Leu Arg Glu Ala 
145                 150                 155                 160 


Val Ala Glu Cys Leu Asn His Asn Leu Thr Ile Phe Phe Asp Val Lys 
                165                 170                 175     


Gly His Ala His Lys Ala Thr Glu Ala Leu Lys Lys Met Tyr Met Glu 
            180                 185                 190         


Phe Pro Gln Leu Tyr Asn Asn Ser Val Val Cys Ser Phe Leu Pro Glu 
        195                 200                 205             


Val Ile Tyr Lys Met Arg Gln Thr Asp Arg Asp Val Ile Thr Ala Leu 
    210                 215                 220                 


Thr His Arg Pro Trp Ser Leu Ser His Thr Gly Asp Gly Lys Pro Arg 
225                 230                 235                 240 


Tyr Asp Thr Phe Trp Lys His Phe Ile Phe Val Met Met Asp Ile Leu 
                245                 250                 255     


Leu Asp Trp Ser Met His Asn Ile Leu Trp Tyr Leu Cys Gly Ile Ser 
            260                 265                 270         


Ala Phe Leu Met Gln Lys Asp Phe Val Ser Pro Ala Tyr Leu Lys Lys 
        275                 280                 285             


Trp Ser Ala Lys Gly Ile Gln Val Val Gly Trp Thr Val Asn Thr Phe 
    290                 295                 300                 


Asp Glu Lys Ser Tyr Tyr Glu Ser His Leu Gly Ser Ser Tyr Ile Thr 
305                 310                 315                 320 


Asp Ser Met Val Glu Asp Cys Glu Pro His Phe 
                325                 330     


<210>  4266
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  4266

Met Asn Val Phe Arg Ile Leu Gly Asp Leu Ser His Leu Leu Ala Met 
1               5                   10                  15      


Ile Leu Leu Leu Gly Lys Ile Trp Arg Ser Lys Cys Cys Lys Gly Ile 
            20                  25                  30          


Ser Gly Lys Ser Gln Ile Leu Phe Ala Leu Val Phe Thr Thr Arg Tyr 
        35                  40                  45              


Leu Asp Leu Phe Thr Asn Phe Ile Ser Ile Tyr Asn Thr Val Met Lys 
    50                  55                  60                  


Val Val Phe Leu Leu Cys Ala Tyr Val Thr Val Tyr Met Ile Tyr Gly 
65                  70                  75                  80  


Lys Phe Arg Lys Thr Phe Asp Ser Glu Asn Asp Thr Phe Arg Leu Glu 
                85                  90                  95      


Phe Leu Leu Val Pro Val Ile Gly Leu Ser Phe Leu Glu Asn Tyr Ser 
            100                 105                 110         


Phe Thr Leu Leu Glu Ile Leu Trp Thr Phe Ser Ile Tyr Leu Glu Ser 
        115                 120                 125             


Val Ala Ile Leu Pro Gln Leu Phe Met Ile Ser Lys Thr Gly Glu Ala 
    130                 135                 140                 


Glu Thr Ile Thr Thr His Tyr Leu Phe Phe Leu Gly Leu Tyr Arg Ala 
145                 150                 155                 160 


Leu Tyr Leu Ala Asn Trp Ile Arg Arg Tyr Gln Thr Glu Asn Phe Tyr 
                165                 170                 175     


Asp Gln Ile Ala Val Val Ser Gly Val Val Gln Thr Ile Phe Tyr Cys 
            180                 185                 190         


Asp Phe Phe Tyr Leu Tyr Val Thr Lys Gly Arg Ser Trp Asp Asp Ser 
        195                 200                 205             


Asn Ala Asp Thr Gly Leu Arg Ser Tyr Ser Ser Ile 
    210                 215                 220 


<210>  4267
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  4267

Met Ala Gln Arg Met Thr Thr Gln Leu Leu Leu Leu Leu Val Trp Val 
1               5                   10                  15      


Ala Val Val Gly Glu Ala Gln Thr Arg Ile Ala Trp Ala Arg Thr Glu 
            20                  25                  30          


Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly 
        35                  40                  45              


Pro Glu Asp Lys Leu His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala 
    50                  55                  60                  


Cys Cys Ser Thr Asn Thr Ser Gln Glu Ala His Lys Asp Val Ser Tyr 
65                  70                  75                  80  


Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Cys 
                85                  90                  95      


Lys Arg His Phe Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn 
            100                 105                 110         


Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg 
        115                 120                 125             


Val Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Gln Trp Trp Glu 
    130                 135                 140                 


Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp 
145                 150                 155                 160 


Asn Trp Thr Ser Gly Phe Asn Lys Cys Ala Val Gly Ala Ala Cys Gln 
                165                 170                 175     


Pro Phe His Phe Tyr Phe Pro Thr Pro Thr Val Leu Cys Asn Glu Ile 
            180                 185                 190         


Trp Thr His Ser Tyr Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg 
        195                 200                 205             


Cys Ile Gln Met Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu Glu 
    210                 215                 220                 


Val Ala Arg Phe Tyr Ala Ala Ala Met Ser Gly Ala Gly Pro Trp Ala 
225                 230                 235                 240 


Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu 
                245                 250                 255     


Ser 
    


<210>  4268
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  4268

Met Ala Gln Arg Met Thr Thr Gln Leu Leu Leu Leu Leu Val Trp Val 
1               5                   10                  15      


Ala Val Val Gly Glu Ala Gln Thr Arg Ile Ala Trp Ala Arg Thr Glu 
            20                  25                  30          


Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly 
        35                  40                  45              


Pro Glu Asp Lys Leu His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala 
    50                  55                  60                  


Cys Cys Ser Thr Asn Thr Ser Gln Glu Ala His Lys Asp Val Ser Tyr 
65                  70                  75                  80  


Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Cys 
                85                  90                  95      


Lys Arg His Phe Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn 
            100                 105                 110         


Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg 
        115                 120                 125             


Val Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Gln Trp Trp Glu 
    130                 135                 140                 


Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp 
145                 150                 155                 160 


Asn Trp Thr Ser Gly Phe Asn Lys Cys Ala Val Gly Ala Ala Cys Gln 
                165                 170                 175     


Pro Phe His Phe Tyr Phe Pro Thr Pro Thr Val Leu Cys Asn Glu Ile 
            180                 185                 190         


Trp Thr His Ser Tyr Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg 
        195                 200                 205             


Cys Ile Gln Met Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu Glu 
    210                 215                 220                 


Val Ala Arg Phe Tyr Ala Ala Ala Met Ser Gly Ala Gly Pro Trp Ala 
225                 230                 235                 240 


Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu 
                245                 250                 255     


Ser 
    


<210>  4269
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  4269

Met Ala Gln Arg Met Thr Thr Gln Leu Leu Leu Leu Leu Val Trp Val 
1               5                   10                  15      


Ala Val Val Gly Glu Ala Gln Thr Arg Ile Ala Trp Ala Arg Thr Glu 
            20                  25                  30          


Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly 
        35                  40                  45              


Pro Glu Asp Lys Leu His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala 
    50                  55                  60                  


Cys Cys Ser Thr Asn Thr Ser Gln Glu Ala His Lys Asp Val Ser Tyr 
65                  70                  75                  80  


Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Cys 
                85                  90                  95      


Lys Arg His Phe Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn 
            100                 105                 110         


Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg 
        115                 120                 125             


Val Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Gln Trp Trp Glu 
    130                 135                 140                 


Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp 
145                 150                 155                 160 


Asn Trp Thr Ser Gly Phe Asn Lys Cys Ala Val Gly Ala Ala Cys Gln 
                165                 170                 175     


Pro Phe His Phe Tyr Phe Pro Thr Pro Thr Val Leu Cys Asn Glu Ile 
            180                 185                 190         


Trp Thr His Ser Tyr Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg 
        195                 200                 205             


Cys Ile Gln Met Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu Glu 
    210                 215                 220                 


Val Ala Arg Phe Tyr Ala Ala Ala Met Ser Gly Ala Gly Pro Trp Ala 
225                 230                 235                 240 


Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu 
                245                 250                 255     


Ser 
    


<210>  4270
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  4270

Met Ala Gln Arg Met Thr Thr Gln Leu Leu Leu Leu Leu Val Trp Val 
1               5                   10                  15      


Ala Val Val Gly Glu Ala Gln Thr Arg Ile Ala Trp Ala Arg Thr Glu 
            20                  25                  30          


Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly 
        35                  40                  45              


Pro Glu Asp Lys Leu His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala 
    50                  55                  60                  


Cys Cys Ser Thr Asn Thr Ser Gln Glu Ala His Lys Asp Val Ser Tyr 
65                  70                  75                  80  


Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Cys 
                85                  90                  95      


Lys Arg His Phe Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn 
            100                 105                 110         


Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg 
        115                 120                 125             


Val Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Gln Trp Trp Glu 
    130                 135                 140                 


Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp 
145                 150                 155                 160 


Asn Trp Thr Ser Gly Phe Asn Lys Cys Ala Val Gly Ala Ala Cys Gln 
                165                 170                 175     


Pro Phe His Phe Tyr Phe Pro Thr Pro Thr Val Leu Cys Asn Glu Ile 
            180                 185                 190         


Trp Thr His Ser Tyr Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg 
        195                 200                 205             


Cys Ile Gln Met Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu Glu 
    210                 215                 220                 


Val Ala Arg Phe Tyr Ala Ala Ala Met Ser Gly Ala Gly Pro Trp Ala 
225                 230                 235                 240 


Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu 
                245                 250                 255     


Ser 
    


<210>  4271
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  4271

Met Ala Gln Arg Met Thr Thr Gln Leu Leu Leu Leu Leu Val Trp Val 
1               5                   10                  15      


Ala Val Val Gly Glu Ala Gln Thr Arg Ile Ala Trp Ala Arg Thr Glu 
            20                  25                  30          


Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly 
        35                  40                  45              


Pro Glu Asp Lys Leu His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala 
    50                  55                  60                  


Cys Cys Ser Thr Asn Thr Ser Gln Glu Ala His Lys Asp Val Ser Tyr 
65                  70                  75                  80  


Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Cys 
                85                  90                  95      


Lys Arg His Phe Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn 
            100                 105                 110         


Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg 
        115                 120                 125             


Val Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Gln Trp Trp Glu 
    130                 135                 140                 


Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp 
145                 150                 155                 160 


Asn Trp Thr Ser Gly Phe Asn Lys Cys Ala Val Gly Ala Ala Cys Gln 
                165                 170                 175     


Pro Phe His Phe Tyr Phe Pro Thr Pro Thr Val Leu Cys Asn Glu Ile 
            180                 185                 190         


Trp Thr His Ser Tyr Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg 
        195                 200                 205             


Cys Ile Gln Met Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu Glu 
    210                 215                 220                 


Val Ala Arg Phe Tyr Ala Ala Ala Met Ser Gly Ala Gly Pro Trp Ala 
225                 230                 235                 240 


Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu 
                245                 250                 255     


Ser 
    


<210>  4272
<211>  666
<212>  PRT
<213>  Homo sapiens

<400>  4272

Met Ala Cys Leu Met Ala Ala Phe Ser Val Gly Thr Ala Met Asn Ala 
1               5                   10                  15      


Ser Ser Tyr Ser Ala Glu Met Thr Glu Pro Lys Ser Val Cys Val Ser 
            20                  25                  30          


Val Asp Glu Val Val Ser Ser Asn Met Glu Ala Thr Glu Thr Asp Leu 
        35                  40                  45              


Leu Asn Gly His Leu Lys Lys Val Asp Asn Asn Leu Thr Glu Ala Gln 
    50                  55                  60                  


Arg Phe Ser Ser Leu Pro Arg Arg Ala Ala Val Asn Ile Glu Phe Arg 
65                  70                  75                  80  


Asp Leu Ser Tyr Ser Val Pro Glu Gly Pro Trp Trp Arg Lys Lys Gly 
                85                  90                  95      


Tyr Lys Thr Leu Leu Lys Gly Ile Ser Gly Lys Phe Asn Ser Gly Glu 
            100                 105                 110         


Leu Val Ala Ile Met Gly Pro Ser Gly Ala Gly Lys Ser Thr Leu Met 
        115                 120                 125             


Asn Ile Leu Ala Gly Tyr Arg Glu Thr Gly Met Lys Gly Ala Val Leu 
    130                 135                 140                 


Ile Asn Gly Leu Pro Arg Asp Leu Arg Cys Phe Arg Lys Val Ser Cys 
145                 150                 155                 160 


Tyr Ile Met Gln Asp Asp Met Leu Leu Pro His Leu Thr Val Gln Glu 
                165                 170                 175     


Ala Met Met Val Ser Ala His Leu Lys Leu Gln Glu Lys Asp Glu Gly 
            180                 185                 190         


Arg Arg Glu Met Val Lys Glu Ile Leu Thr Ala Leu Gly Leu Leu Ser 
        195                 200                 205             


Cys Ala Asn Thr Arg Thr Gly Ser Leu Ser Gly Gly Gln Arg Lys Arg 
    210                 215                 220                 


Leu Ala Ile Ala Leu Glu Leu Val Asn Asn Pro Pro Val Met Phe Phe 
225                 230                 235                 240 


Asp Glu Pro Thr Ser Gly Leu Asp Ser Ala Ser Cys Phe Gln Val Val 
                245                 250                 255     


Ser Leu Met Lys Gly Leu Ala Gln Gly Gly Arg Ser Ile Ile Cys Thr 
            260                 265                 270         


Ile His Gln Pro Ser Ala Lys Leu Phe Glu Leu Phe Asp Gln Leu Tyr 
        275                 280                 285             


Val Leu Ser Gln Gly Gln Cys Val Tyr Arg Gly Lys Val Cys Asn Leu 
    290                 295                 300                 


Val Pro Tyr Leu Arg Asp Leu Gly Leu Asn Cys Pro Thr Tyr His Asn 
305                 310                 315                 320 


Pro Ala Asp Phe Val Met Glu Val Ala Ser Gly Glu Tyr Gly Asp Gln 
                325                 330                 335     


Asn Ser Arg Leu Val Arg Ala Val Arg Glu Gly Met Cys Asp Ser Asp 
            340                 345                 350         


His Lys Arg Asp Leu Gly Gly Asp Ala Glu Val Asn Pro Phe Leu Trp 
        355                 360                 365             


His Arg Pro Ser Glu Glu Asp Ser Ser Ser Met Glu Gly Cys His Ser 
    370                 375                 380                 


Phe Ser Ala Ser Cys Leu Thr Gln Phe Cys Ile Leu Phe Lys Arg Thr 
385                 390                 395                 400 


Phe Leu Ser Ile Met Arg Asp Ser Val Leu Thr His Leu Arg Ile Thr 
                405                 410                 415     


Ser His Ile Gly Ile Gly Leu Leu Ile Gly Leu Leu Tyr Leu Gly Ile 
            420                 425                 430         


Gly Asn Glu Ala Lys Lys Val Leu Ser Asn Ser Gly Phe Leu Phe Phe 
        435                 440                 445             


Ser Met Leu Phe Leu Met Phe Ala Ala Leu Met Pro Thr Val Leu Thr 
    450                 455                 460                 


Phe Pro Leu Glu Met Gly Val Phe Leu Arg Glu His Leu Asn Tyr Trp 
465                 470                 475                 480 


Tyr Ser Leu Lys Ala Tyr Tyr Leu Ala Lys Thr Met Ala Asp Val Pro 
                485                 490                 495     


Phe Gln Ile Met Phe Pro Val Ala Tyr Cys Ser Ile Val Tyr Trp Met 
            500                 505                 510         


Thr Ser Gln Pro Ser Asp Ala Val Arg Phe Val Leu Phe Ala Ala Leu 
        515                 520                 525             


Gly Thr Met Thr Ser Leu Val Ala Gln Ser Leu Gly Leu Leu Ile Gly 
    530                 535                 540                 


Ala Ala Ser Thr Ser Leu Gln Val Ala Thr Phe Val Gly Pro Val Thr 
545                 550                 555                 560 


Ala Ile Pro Val Leu Leu Phe Ser Gly Phe Phe Val Ser Phe Asp Thr 
                565                 570                 575     


Ile Pro Thr Tyr Leu Gln Trp Met Ser Tyr Ile Ser Tyr Val Arg Tyr 
            580                 585                 590         


Gly Phe Glu Gly Val Ile Leu Ser Ile Tyr Gly Leu Asp Arg Glu Asp 
        595                 600                 605             


Leu His Cys Asp Ile Asp Glu Thr Cys His Phe Gln Lys Ser Glu Ala 
    610                 615                 620                 


Ile Leu Arg Glu Leu Asp Val Glu Asn Ala Lys Leu Tyr Leu Asp Phe 
625                 630                 635                 640 


Ile Val Leu Gly Ile Phe Phe Ile Ser Leu Arg Leu Ile Ala Tyr Phe 
                645                 650                 655     


Val Leu Arg Tyr Lys Ile Arg Ala Glu Arg 
            660                 665     


<210>  4273
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  4273

Met Ser Ala Pro Ala Gln Pro Pro Ala Glu Gly Thr Glu Gly Thr Ala 
1               5                   10                  15      


Pro Gly Gly Gly Pro Pro Gly Pro Pro Pro Asn Met Thr Ser Asn Arg 
            20                  25                  30          


Arg Leu Gln Gln Thr Gln Ala Gln Val Glu Glu Val Val Asp Ile Ile 
        35                  40                  45              


Arg Val Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu 
    50                  55                  60                  


Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu 
65                  70                  75                  80  


Ser Ser Ala Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Cys Lys 
                85                  90                  95      


Met Met Ile Met Leu Gly Ala Ile Cys Ala Ile Ile Val Val Val Ile 
            100                 105                 110         


Val Arg Arg Asp 
        115     


<210>  4274
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  4274

Met Ala Val Asp Ile Thr Leu Leu Phe Arg Ala Ser Val Lys Thr Val 
1               5                   10                  15      


Lys Thr Arg Asn Lys Ala Leu Gly Val Ala Val Gly Gly Gly Val Asp 
            20                  25                  30          


Gly Ser Arg Asp Glu Leu Phe Arg Arg Ser Pro Arg Pro Lys Gly Asp 
        35                  40                  45              


Phe Ser Ser Arg Ala Arg Glu Val Ile Ser His Ile Gly Lys Leu Arg 
    50                  55                  60                  


Asp Phe Leu Leu Glu His Arg Lys Asp Tyr Ile Asn Ala Tyr Ser His 
65                  70                  75                  80  


Thr Met Ser Glu Tyr Gly Arg Met Thr Asp Thr Glu Arg Asp Gln Ile 
                85                  90                  95      


Asp Gln Asp Ala Gln Ile Phe Met Arg Thr Cys Ser Glu Ala Ile Gln 
            100                 105                 110         


Gln Leu Arg Thr Glu Ala His Lys Glu Ile His Ser Gln Gln Val Lys 
        115                 120                 125             


Glu His Arg Thr Ala Val Leu Asp Phe Ile Glu Asp Tyr Leu Lys Arg 
    130                 135                 140                 


Val Cys Lys Leu Tyr Ser Glu Gln Arg Ala Ile Arg Val Lys Arg Val 
145                 150                 155                 160 


Val Asp Lys Lys Arg Leu Ser Lys Leu Glu Pro Glu Pro Asn Thr Lys 
                165                 170                 175     


Thr Arg Glu Ser Thr Ser Ser Glu Lys Val Ser Gln Ser Pro Ser Lys 
            180                 185                 190         


Asp Ser Glu Glu Asn Pro Ala Thr Glu Glu Arg Pro Glu Lys Ile Leu 
        195                 200                 205             


Ala Glu Thr Gln Pro Glu Leu Gly Thr Trp Gly Asp Gly Lys Gly Glu 
    210                 215                 220                 


Asp Glu Leu Ser Pro Glu Glu Ile Gln Met Phe Glu Gln Glu Asn Gln 
225                 230                 235                 240 


Arg Leu Ile Gly Glu Met Asn Ser Leu Phe Asp Glu Val Arg Gln Ile 
                245                 250                 255     


Glu Gly Arg Val Val Glu Ile Ser Arg Leu Gln Glu Ile Phe Thr Glu 
            260                 265                 270         


Lys Val Leu Gln Gln Glu Ala Glu Ile Asp Ser Ile His Gln Leu Val 
        275                 280                 285             


Val Gly Ala Thr Glu Asn Ile Lys Glu Gly Asn Glu Asp Ile Arg Glu 
    290                 295                 300                 


Ala Ile Lys Asn Asn Ala Gly Phe Arg Val Trp Ile Leu Phe Phe Leu 
305                 310                 315                 320 


Val Met Cys Ser Phe Ser Leu Leu Phe Leu Asp Trp Tyr Asp Ser 
                325                 330                 335 


<210>  4275
<211>  618
<212>  PRT
<213>  Homo sapiens

<400>  4275

Met Val Ser Pro Arg Met Ser Gly Leu Leu Ser Gln Thr Val Ile Leu 
1               5                   10                  15      


Ala Leu Ile Phe Leu Pro Gln Thr Arg Pro Ala Gly Val Phe Glu Leu 
            20                  25                  30          


Gln Ile His Ser Phe Gly Pro Gly Pro Gly Pro Gly Ala Pro Arg Ser 
        35                  40                  45              


Pro Cys Ser Ala Arg Leu Pro Cys Arg Leu Phe Phe Arg Val Cys Leu 
    50                  55                  60                  


Lys Pro Gly Leu Ser Glu Glu Ala Ala Glu Ser Pro Cys Ala Leu Gly 
65                  70                  75                  80  


Ala Ala Leu Ser Ala Arg Gly Pro Val Tyr Thr Glu Gln Pro Gly Ala 
                85                  90                  95      


Pro Ala Pro Asp Leu Pro Leu Pro Asp Gly Leu Leu Gln Val Pro Phe 
            100                 105                 110         


Arg Asp Ala Trp Pro Gly Thr Phe Ser Phe Ile Ile Glu Thr Trp Arg 
        115                 120                 125             


Glu Glu Leu Gly Asp Gln Ile Gly Gly Pro Ala Trp Ser Leu Leu Ala 
    130                 135                 140                 


Arg Val Ala Gly Arg Arg Arg Leu Ala Ala Gly Gly Pro Trp Ala Arg 
145                 150                 155                 160 


Asp Ile Gln Arg Ala Gly Ala Trp Glu Leu Arg Phe Ser Tyr Arg Ala 
                165                 170                 175     


Arg Cys Glu Pro Pro Ala Val Gly Thr Ala Cys Thr Arg Leu Cys Arg 
            180                 185                 190         


Pro Arg Ser Ala Pro Ser Arg Cys Gly Pro Gly Leu Arg Pro Cys Ala 
        195                 200                 205             


Pro Leu Glu Asp Glu Cys Glu Ala Pro Leu Val Cys Arg Ala Gly Cys 
    210                 215                 220                 


Ser Pro Glu His Gly Phe Cys Glu Gln Pro Gly Glu Cys Arg Cys Leu 
225                 230                 235                 240 


Glu Gly Trp Thr Gly Pro Leu Cys Thr Val Pro Val Ser Thr Ser Ser 
                245                 250                 255     


Cys Leu Ser Pro Arg Gly Pro Ser Ser Ala Thr Thr Gly Cys Leu Val 
            260                 265                 270         


Pro Gly Pro Gly Pro Cys Asp Gly Asn Pro Cys Ala Asn Gly Gly Ser 
        275                 280                 285             


Cys Ser Glu Thr Pro Arg Ser Phe Glu Cys Thr Cys Pro Arg Gly Phe 
    290                 295                 300                 


Tyr Gly Leu Arg Cys Glu Val Ser Gly Val Thr Cys Ala Asp Gly Pro 
305                 310                 315                 320 


Cys Phe Asn Gly Gly Leu Cys Val Gly Gly Ala Asp Pro Asp Ser Ala 
                325                 330                 335     


Tyr Ile Cys His Cys Pro Pro Gly Phe Gln Gly Ser Asn Cys Glu Lys 
            340                 345                 350         


Arg Val Asp Arg Cys Ser Leu Gln Pro Cys Arg Asn Gly Gly Leu Cys 
        355                 360                 365             


Leu Asp Leu Gly His Ala Leu Arg Cys Arg Cys Arg Ala Gly Phe Ala 
    370                 375                 380                 


Gly Pro Arg Cys Glu His Asp Leu Asp Asp Cys Ala Gly Arg Ala Cys 
385                 390                 395                 400 


Ala Asn Gly Gly Thr Cys Val Glu Gly Gly Gly Ala His Arg Cys Ser 
                405                 410                 415     


Cys Ala Leu Gly Phe Gly Gly Arg Asp Cys Arg Glu Arg Ala Asp Pro 
            420                 425                 430         


Cys Ala Ala Arg Pro Cys Ala His Gly Gly Arg Cys Tyr Ala His Phe 
        435                 440                 445             


Ser Gly Leu Val Cys Ala Cys Ala Pro Gly Tyr Met Gly Ala Arg Cys 
    450                 455                 460                 


Glu Phe Pro Val His Pro Asp Gly Ala Ser Ala Leu Pro Ala Ala Pro 
465                 470                 475                 480 


Pro Gly Leu Arg Pro Gly Asp Pro Gln Arg Tyr Leu Leu Pro Pro Ala 
                485                 490                 495     


Leu Gly Leu Leu Val Ala Ala Gly Val Ala Gly Ala Ala Leu Leu Leu 
            500                 505                 510         


Val His Val Arg Arg Arg Gly His Ser Gln Asp Ala Gly Ser Arg Leu 
        515                 520                 525             


Leu Ala Gly Thr Pro Glu Pro Ser Val His Ala Leu Pro Asp Ala Leu 
    530                 535                 540                 


Asn Asn Leu Arg Thr Gln Glu Gly Ser Gly Asp Gly Pro Ser Ser Ser 
545                 550                 555                 560 


Val Asp Trp Asn Arg Pro Glu Asp Val Asp Pro Gln Gly Ile Tyr Val 
                565                 570                 575     


Ile Ser Ala Pro Ser Ile Tyr Ala Arg Glu Val Ala Thr Pro Leu Phe 
            580                 585                 590         


Pro Pro Leu His Thr Gly Arg Ala Gly Gln Arg Gln His Leu Leu Phe 
        595                 600                 605             


Pro Tyr Pro Ser Ser Ile Leu Ser Val Lys 
    610                 615             


<210>  4276
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  4276

Met Met Gly Leu Thr Glu Gly Val Phe Leu Ile Leu Ser Gly Thr Gln 
1               5                   10                  15      


Phe Thr Leu Gly Ile Leu Val Asn Cys Phe Ile Glu Leu Val Asn Gly 
            20                  25                  30          


Ser Ser Trp Phe Lys Thr Lys Arg Met Ser Leu Ser Asp Phe Ile Ile 
        35                  40                  45              


Thr Thr Leu Ala Leu Leu Arg Ile Ile Leu Leu Cys Ile Ile Leu Thr 
    50                  55                  60                  


Asp Ser Phe Leu Ile Glu Phe Ser Pro Asn Thr His Asp Ser Gly Ile 
65                  70                  75                  80  


Ile Met Gln Ile Ile Asp Val Ser Trp Thr Phe Thr Asn His Leu Ser 
                85                  90                  95      


Ile Trp Leu Ala Thr Cys Leu Gly Val Leu Tyr Cys Leu Lys Ile Ala 
            100                 105                 110         


Ser Phe Ser His Pro Thr Phe Leu Trp Leu Lys Trp Arg Val Ser Arg 
        115                 120                 125             


Val Met Val Trp Met Leu Leu Gly Ala Leu Leu Leu Ser Cys Gly Ser 
    130                 135                 140                 


Thr Ala Ser Leu Ile Asn Glu Phe Lys Leu Tyr Ser Val Phe Arg Gly 
145                 150                 155                 160 


Ile Glu Ala Thr Arg Asn Val Thr Glu His Phe Arg Lys Lys Arg Ser 
                165                 170                 175     


Glu Tyr Tyr Leu Ile His Val Leu Gly Thr Leu Trp Tyr Leu Pro Pro 
            180                 185                 190         


Leu Ile Val Ser Leu Ala Ser Tyr Ser Leu Leu Ile Phe Ser Leu Gly 
        195                 200                 205             


Arg His Thr Arg Gln Met Leu Gln Asn Gly Thr Ser Ser Arg Asp Pro 
    210                 215                 220                 


Thr Thr Glu Ala His Lys Arg Ala Ile Arg Ile Ile Leu Ser Phe Phe 
225                 230                 235                 240 


Phe Leu Phe Leu Leu Tyr Phe Leu Ala Phe Leu Ile Ala Ser Phe Gly 
                245                 250                 255     


Asn Phe Leu Pro Lys Thr Lys Met Ala Lys Met Ile Gly Glu Val Met 
            260                 265                 270         


Thr Met Phe Tyr Pro Ala Gly His Ser Phe Ile Leu Ile Leu Gly Asn 
        275                 280                 285             


Ser Lys Leu Lys Gln Thr Phe Val Val Met Leu Arg Cys Glu Ser Gly 
    290                 295                 300                 


His Leu Lys Pro Gly Ser Lys Gly Pro Ile Phe Ser 
305                 310                 315     


<210>  4277
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  4277

Met Ile Pro Ile Gln Leu Thr Val Phe Phe Met Ile Ile Tyr Val Leu 
1               5                   10                  15      


Glu Ser Leu Thr Ile Ile Val Gln Ser Ser Leu Ile Val Ala Val Leu 
            20                  25                  30          


Gly Arg Glu Trp Leu Gln Val Arg Arg Leu Met Pro Val Asp Met Ile 
        35                  40                  45              


Leu Ile Ser Leu Gly Ile Ser Arg Phe Cys Leu Gln Trp Ala Ser Met 
    50                  55                  60                  


Leu Asn Asn Phe Cys Ser Tyr Phe Asn Leu Asn Tyr Val Leu Cys Asn 
65                  70                  75                  80  


Leu Thr Ile Thr Trp Glu Phe Phe Asn Ile Leu Thr Phe Trp Leu Asn 
                85                  90                  95      


Ser Leu Leu Thr Val Phe Tyr Cys Ile Lys Val Ser Ser Phe Thr His 
            100                 105                 110         


His Ile Phe Leu Trp Leu Arg Trp Arg Ile Leu Arg Leu Phe Pro Trp 
        115                 120                 125             


Ile Leu Leu Gly Ser Leu Met Ile Thr Cys Val Thr Ile Ile Pro Ser 
    130                 135                 140                 


Ala Ile Gly Asn Tyr Ile Gln Ile Gln Leu Leu Thr Met Glu His Leu 
145                 150                 155                 160 


Pro Arg Asn Ser Thr Val Thr Asp Lys Leu Glu Asn Phe His Gln Tyr 
                165                 170                 175     


Gln Phe Gln Ala His Thr Val Ala Leu Val Ile Pro Phe Ile Leu Phe 
            180                 185                 190         


Leu Ala Ser Thr Ile Phe Leu Met Ala Ser Leu Thr Lys Gln Ile Gln 
        195                 200                 205             


His His Ser Thr Gly His Cys Asn Pro Ser Met Lys Ala Arg Phe Thr 
    210                 215                 220                 


Ala Leu Arg Ser Leu Ala Val Leu Phe Ile Val Phe Thr Ser Tyr Phe 
225                 230                 235                 240 


Leu Thr Ile Leu Ile Thr Ile Ile Gly Thr Leu Phe Asp Lys Arg Cys 
                245                 250                 255     


Trp Leu Trp Val Trp Glu Ala Phe Val Tyr Ala Phe Ile Leu Met His 
            260                 265                 270         


Ser Thr Ser Leu Met Leu Ser Ser Pro Thr Leu Lys Arg Ile Leu Lys 
        275                 280                 285             


Gly Lys Cys 
    290     


<210>  4278
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  4278

Met Gly Thr Lys Ala Gln Val Glu Arg Lys Leu Leu Cys Leu Phe Ile 
1               5                   10                  15      


Leu Ala Ile Leu Leu Cys Ser Leu Ala Leu Gly Ser Val Thr Val His 
            20                  25                  30          


Ser Ser Glu Pro Glu Val Arg Ile Pro Glu Asn Asn Pro Val Lys Leu 
        35                  40                  45              


Ser Cys Ala Tyr Ser Gly Phe Ser Ser Pro Arg Val Glu Trp Lys Phe 
    50                  55                  60                  


Asp Gln Gly Asp Thr Thr Arg Leu Val Cys Tyr Asn Asn Lys Ile Thr 
65                  70                  75                  80  


Ala Ser Tyr Glu Asp Arg Val Thr Phe Leu Pro Thr Gly Ile Thr Phe 
                85                  90                  95      


Lys Ser Val Thr Arg Glu Asp Thr Gly Thr Tyr Thr Cys Met Val Ser 
            100                 105                 110         


Glu Glu Gly Gly Asn Ser Tyr Gly Glu Val Lys Val Lys Leu Ile Val 
        115                 120                 125             


Leu Val Pro Pro Ser Lys Pro Thr Val Asn Ile Pro Ser Ser Ala Thr 
    130                 135                 140                 


Ile Gly Asn Arg Ala Val Leu Thr Cys Ser Glu Gln Asp Gly Ser Pro 
145                 150                 155                 160 


Pro Ser Glu Tyr Thr Trp Phe Lys Asp Gly Ile Val Met Pro Thr Asn 
                165                 170                 175     


Pro Lys Ser Thr Arg Ala Phe Ser Asn Ser Ser Tyr Val Leu Asn Pro 
            180                 185                 190         


Thr Thr Gly Glu Leu Val Phe Asp Pro Leu Ser Ala Ser Asp Thr Gly 
        195                 200                 205             


Glu Tyr Ser Cys Glu Ala Arg Asn Gly Tyr Gly Thr Pro Met Thr Ser 
    210                 215                 220                 


Asn Ala Val Arg Met Glu Ala Val Glu Arg Asn Val Gly Val Ile Val 
225                 230                 235                 240 


Ala Ala Val Leu Val Thr Leu Ile Leu Leu Gly Ile Leu Val Phe Gly 
                245                 250                 255     


Ile Trp Phe Ala Tyr Ser Arg Gly His Phe Asp Arg Thr Lys Lys Gly 
            260                 265                 270         


Thr Ser Ser Lys Lys Val Ile Tyr Ser Gln Pro Ser Ala Arg Ser Glu 
        275                 280                 285             


Gly Glu Phe Lys Gln Thr Ser Ser Phe Leu Val 
    290                 295                 


<210>  4279
<211>  436
<212>  PRT
<213>  Homo sapiens

<400>  4279

Met Leu Lys Val Ser Ala Val Leu Cys Val Cys Ala Ala Ala Trp Cys 
1               5                   10                  15      


Ser Gln Ser Leu Ala Ala Ala Ala Ala Val Ala Ala Ala Gly Gly Arg 
            20                  25                  30          


Ser Asp Gly Gly Asn Phe Leu Asp Asp Lys Gln Trp Leu Thr Thr Ile 
        35                  40                  45              


Ser Gln Tyr Asp Lys Glu Val Gly Gln Trp Asn Lys Phe Arg Asp Glu 
    50                  55                  60                  


Val Glu Asp Asp Tyr Phe Arg Thr Trp Ser Pro Gly Lys Pro Phe Asp 
65                  70                  75                  80  


Gln Ala Leu Asp Pro Ala Lys Asp Pro Cys Leu Lys Met Lys Cys Ser 
                85                  90                  95      


Arg His Lys Val Cys Ile Ala Gln Asp Ser Gln Thr Ala Val Cys Ile 
            100                 105                 110         


Ser His Arg Arg Leu Thr His Arg Met Lys Glu Ala Gly Val Asp His 
        115                 120                 125             


Arg Gln Trp Arg Gly Pro Ile Leu Ser Thr Cys Lys Gln Cys Pro Val 
    130                 135                 140                 


Val Tyr Pro Ser Pro Val Cys Gly Ser Asp Gly His Thr Tyr Ser Phe 
145                 150                 155                 160 


Gln Cys Lys Leu Glu Tyr Gln Ala Cys Val Leu Gly Lys Gln Ile Ser 
                165                 170                 175     


Val Lys Cys Glu Gly His Cys Pro Cys Pro Ser Asp Lys Pro Thr Ser 
            180                 185                 190         


Thr Ser Arg Asn Val Lys Arg Ala Cys Ser Asp Leu Glu Phe Arg Glu 
        195                 200                 205             


Val Ala Asn Arg Leu Arg Asp Trp Phe Lys Ala Leu His Glu Ser Gly 
    210                 215                 220                 


Ser Gln Asn Lys Lys Thr Lys Thr Leu Leu Arg Pro Glu Arg Ser Arg 
225                 230                 235                 240 


Phe Asp Thr Ser Ile Leu Pro Ile Cys Lys Asp Ser Leu Gly Trp Met 
                245                 250                 255     


Phe Asn Arg Leu Asp Thr Asn Tyr Asp Leu Leu Leu Asp Gln Ser Glu 
            260                 265                 270         


Leu Arg Ser Ile Tyr Leu Asp Lys Asn Glu Gln Cys Thr Lys Ala Phe 
        275                 280                 285             


Phe Asn Ser Cys Asp Thr Tyr Lys Asp Ser Leu Ile Ser Asn Asn Glu 
    290                 295                 300                 


Trp Cys Tyr Cys Phe Gln Arg Gln Gln Asp Pro Pro Cys Gln Thr Glu 
305                 310                 315                 320 


Leu Ser Asn Ile Gln Lys Arg Gln Gly Val Lys Lys Leu Leu Gly Gln 
                325                 330                 335     


Tyr Ile Pro Leu Cys Asp Glu Asp Gly Tyr Tyr Lys Pro Thr Gln Cys 
            340                 345                 350         


His Gly Ser Val Gly Gln Cys Trp Cys Val Asp Arg Tyr Gly Asn Glu 
        355                 360                 365             


Val Met Gly Ser Arg Ile Asn Gly Val Ala Asp Cys Ala Ile Asp Phe 
    370                 375                 380                 


Glu Ile Ser Gly Asp Phe Ala Ser Gly Asp Phe His Glu Trp Thr Asp 
385                 390                 395                 400 


Asp Glu Asp Asp Glu Asp Asp Ile Met Asn Asp Glu Asp Glu Ile Glu 
                405                 410                 415     


Asp Asp Asp Glu Asp Glu Gly Asp Asp Asp Asp Gly Gly Asp Asp His 
            420                 425                 430         


Asp Val Tyr Ile 
        435     


<210>  4280
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  4280

Met Asp Asn Val Gln Pro Lys Ile Lys His Arg Pro Phe Cys Phe Ser 
1               5                   10                  15      


Val Lys Gly His Val Lys Met Leu Arg Leu Ala Leu Thr Val Thr Ser 
            20                  25                  30          


Met Thr Phe Phe Ile Ile Ala Gln Ala Pro Glu Pro Tyr Ile Val Ile 
        35                  40                  45              


Thr Gly Phe Glu Val Thr Val Ile Leu Phe Phe Ile Leu Leu Tyr Val 
    50                  55                  60                  


Leu Arg Leu Asp Arg Leu Met Lys Trp Leu Phe Trp Pro Leu Leu Asp 
65                  70                  75                  80  


Ile Ile Asn Ser Leu Val Thr Thr Val Phe Met Leu Ile Val Ser Val 
                85                  90                  95      


Leu Ala Leu Ile Pro Glu Thr Thr Thr Leu Thr Val Gly Gly Gly Val 
            100                 105                 110         


Phe Ala Leu Val Thr Ala Val Cys Cys Leu Ala Asp Gly Ala Leu Ile 
        115                 120                 125             


Tyr Arg Lys Leu Leu Phe Asn Pro Ser Gly Pro Tyr Gln Lys Lys Pro 
    130                 135                 140                 


Val His Glu Lys Lys Glu Val Leu 
145                 150         


<210>  4281
<211>  1264
<212>  PRT
<213>  Homo sapiens

<400>  4281

Met His Pro Asp Leu Gly Pro Leu Cys Thr Leu Leu Tyr Val Thr Leu 
1               5                   10                  15      


Thr Ile Leu Cys Ser Ser Val Ser Ser Asp Leu Ala Pro Tyr Phe Thr 
            20                  25                  30          


Ser Glu Pro Leu Ser Ala Val Gln Lys Leu Gly Gly Pro Val Val Leu 
        35                  40                  45              


His Cys Ser Ala Gln Pro Val Thr Thr Arg Ile Ser Trp Leu His Asn 
    50                  55                  60                  


Gly Lys Thr Leu Asp Gly Asn Leu Glu His Val Lys Ile His Gln Gly 
65                  70                  75                  80  


Thr Leu Thr Ile Leu Ser Leu Asn Ser Ser Leu Leu Gly Tyr Tyr Gln 
                85                  90                  95      


Cys Leu Ala Asn Asn Ser Ile Gly Ala Ile Val Ser Gly Pro Ala Thr 
            100                 105                 110         


Val Ser Val Ala Val Leu Gly Asp Phe Gly Ser Ser Thr Lys His Val 
        115                 120                 125             


Ile Thr Ala Glu Glu Lys Ser Ala Gly Phe Ile Gly Cys Arg Val Pro 
    130                 135                 140                 


Glu Ser Asn Pro Lys Ala Glu Val Arg Tyr Lys Ile Arg Gly Lys Trp 
145                 150                 155                 160 


Leu Glu His Ser Thr Glu Asn Tyr Leu Ile Leu Pro Ser Gly Asn Leu 
                165                 170                 175     


Gln Ile Leu Asn Val Ser Leu Glu Asp Lys Gly Ser Tyr Lys Cys Ala 
            180                 185                 190         


Ala Tyr Asn Pro Val Thr His Gln Leu Lys Val Glu Pro Ile Gly Arg 
        195                 200                 205             


Lys Leu Leu Val Ser Arg Pro Ser Ser Asp Asp Val His Ile Leu His 
    210                 215                 220                 


Pro Thr His Ser Gln Ala Leu Ala Val Leu Ser Arg Ser Pro Val Thr 
225                 230                 235                 240 


Leu Glu Cys Val Val Ser Gly Val Pro Ala Pro Gln Val Tyr Trp Leu 
                245                 250                 255     


Lys Asp Gly Gln Asp Ile Ala Pro Gly Ser Asn Trp Arg Arg Leu Tyr 
            260                 265                 270         


Ser His Leu Ala Thr Asp Ser Val Asp Pro Ala Asp Ser Gly Asn Tyr 
        275                 280                 285             


Ser Cys Met Ala Gly Asn Lys Ser Gly Asp Val Lys Tyr Val Thr Tyr 
    290                 295                 300                 


Met Val Asn Val Leu Glu His Ala Ser Ile Ser Lys Gly Leu Gln Asp 
305                 310                 315                 320 


Gln Ile Val Ser Leu Gly Ala Thr Val His Phe Thr Cys Asp Val His 
                325                 330                 335     


Gly Asn Pro Ala Pro Asn Cys Thr Trp Phe His Asn Ala Gln Pro Ile 
            340                 345                 350         


His Pro Ser Ala Arg His Leu Thr Ala Gly Asn Gly Leu Lys Ile Ser 
        355                 360                 365             


Gly Val Thr Val Glu Asp Val Gly Met Tyr Gln Cys Val Ala Asp Asn 
    370                 375                 380                 


Gly Ile Gly Phe Met His Ser Thr Gly Arg Leu Glu Ile Glu Asn Asp 
385                 390                 395                 400 


Gly Gly Phe Lys Pro Val Ile Ile Thr Ala Pro Val Ser Ala Lys Val 
                405                 410                 415     


Ala Asp Gly Asp Phe Val Thr Leu Ser Cys Asn Ala Ser Gly Leu Pro 
            420                 425                 430         


Val Pro Val Ile Arg Trp Tyr Asp Ser His Gly Leu Ile Thr Ser His 
        435                 440                 445             


Pro Ser Gln Val Leu Arg Ser Lys Ser Arg Lys Ser Gln Leu Ser Arg 
    450                 455                 460                 


Pro Glu Gly Leu Asn Leu Glu Pro Val Tyr Phe Val Leu Ser Gln Ala 
465                 470                 475                 480 


Gly Ala Ser Ser Leu His Ile Gln Ala Val Thr Gln Glu His Ala Gly 
                485                 490                 495     


Lys Tyr Ile Cys Glu Ala Ala Asn Glu His Gly Thr Thr Gln Ala Glu 
            500                 505                 510         


Ala Ser Leu Met Val Val Pro Phe Glu Thr Asn Thr Lys Ala Glu Thr 
        515                 520                 525             


Val Thr Leu Pro Asp Ala Ala Gln Asn Asp Asp Arg Ser Lys Arg Asp 
    530                 535                 540                 


Gly Ser Glu Thr Gly Leu Leu Ser Ser Phe Pro Val Lys Val His Pro 
545                 550                 555                 560 


Ser Ala Val Glu Ser Ala Pro Glu Lys Asn Ala Ser Gly Ile Ser Val 
                565                 570                 575     


Pro Asp Ala Pro Ile Ile Leu Ser Pro Pro Gln Thr His Thr Pro Asp 
            580                 585                 590         


Thr Tyr Asn Leu Val Trp Arg Ala Gly Lys Asp Gly Gly Leu Pro Ile 
        595                 600                 605             


Asn Ala Tyr Phe Val Lys Tyr Arg Lys Leu Asp Asp Gly Val Gly Met 
    610                 615                 620                 


Leu Gly Ser Trp His Thr Val Arg Val Pro Gly Ser Glu Asn Glu Leu 
625                 630                 635                 640 


His Leu Ala Glu Leu Glu Pro Ser Ser Leu Tyr Glu Val Leu Met Val 
                645                 650                 655     


Ala Arg Ser Ala Ala Gly Glu Gly Gln Pro Ala Met Leu Thr Phe Arg 
            660                 665                 670         


Thr Ser Lys Glu Lys Thr Ala Ser Ser Lys Asn Thr Gln Ala Ser Ser 
        675                 680                 685             


Pro Pro Val Gly Ile Pro Lys Tyr Pro Val Val Ser Glu Ala Ala Asn 
    690                 695                 700                 


Asn Asn Phe Gly Val Val Leu Thr Asp Ser Ser Arg His Ser Gly Val 
705                 710                 715                 720 


Pro Glu Ala Pro Asp Arg Pro Thr Ile Ser Thr Ala Ser Glu Thr Ser 
                725                 730                 735     


Val Tyr Val Thr Trp Ile Pro Arg Ala Asn Gly Gly Ser Pro Ile Thr 
            740                 745                 750         


Ala Phe Lys Val Glu Tyr Lys Arg Met Arg Thr Ser Asn Trp Leu Val 
        755                 760                 765             


Ala Ala Glu Asp Ile Pro Pro Ser Lys Leu Ser Val Glu Val Arg Ser 
    770                 775                 780                 


Leu Glu Pro Gly Ser Thr Tyr Lys Phe Arg Val Ile Ala Ile Asn His 
785                 790                 795                 800 


Tyr Gly Glu Ser Phe Arg Ser Ser Ala Ser Arg Pro Tyr Gln Val Val 
                805                 810                 815     


Gly Phe Pro Asn Arg Phe Ser Ser Arg Pro Ile Thr Gly Pro His Ile 
            820                 825                 830         


Ala Tyr Thr Glu Ala Val Ser Asp Thr Gln Ile Met Leu Lys Trp Thr 
        835                 840                 845             


Tyr Ile Pro Ser Ser Asn Asn Asn Thr Pro Ile Gln Gly Phe Tyr Ile 
    850                 855                 860                 


Tyr Tyr Arg Pro Thr Asp Ser Asp Asn Asp Ser Asp Tyr Lys Arg Asp 
865                 870                 875                 880 


Val Val Glu Gly Ser Lys Gln Trp His Met Ile Gly His Leu Gln Pro 
                885                 890                 895     


Glu Thr Ser Tyr Asp Ile Lys Met Gln Cys Phe Asn Glu Gly Gly Glu 
            900                 905                 910         


Ser Glu Phe Ser Asn Val Met Ile Cys Glu Thr Lys Val Lys Arg Val 
        915                 920                 925             


Pro Gly Ala Ser Glu Tyr Pro Val Lys Asp Leu Ser Thr Pro Pro Asn 
    930                 935                 940                 


Ser Leu Gly Ser Gly Gly Asn Val Gly Pro Ala Thr Ser Pro Ala Arg 
945                 950                 955                 960 


Ser Ser Asp Met Leu Tyr Leu Ile Val Gly Cys Val Leu Gly Val Met 
                965                 970                 975     


Val Leu Ile Leu Met Val Phe Ile Ala Met Cys Leu Trp Lys Asn Arg 
            980                 985                 990         


Gln Gln Asn Thr Ile Gln Lys Tyr  Asp Pro Pro Gly Tyr  Leu Tyr Gln 
        995                 1000                 1005             


Gly Ser  Asp Met Asn Gly Gln  Met Val Asp Tyr Thr  Thr Leu Ser 
    1010                 1015                 1020             


Gly Ala  Ser Gln Ile Asn Gly  Asn Val His Gly Gly  Phe Leu Thr 
    1025                 1030                 1035             


Asn Gly  Gly Leu Ser Ser Gly  Tyr Ser His Leu His  His Lys Val 
    1040                 1045                 1050             


Pro Asn  Ala Val Asn Gly Ile  Val Asn Gly Ser Leu  Asn Gly Gly 
    1055                 1060                 1065             


Leu Tyr  Ser Gly His Ser Asn  Ser Leu Thr Arg Thr  His Val Asp 
    1070                 1075                 1080             


Phe Glu  His Pro His His Leu  Val Asn Gly Gly Gly  Met Tyr Thr 
    1085                 1090                 1095             


Ala Val  Pro Gln Ile Asp Pro  Leu Glu Cys Val Asn  Cys Arg Asn 
    1100                 1105                 1110             


Cys Arg  Asn Asn Asn Arg Cys  Phe Thr Lys Thr Asn  Ser Thr Phe 
    1115                 1120                 1125             


Ser Ser  Ser Pro Pro Pro Val  Val Pro Val Val Ala  Pro Tyr Pro 
    1130                 1135                 1140             


Gln Asp  Gly Leu Glu Met Lys  Pro Leu Ser His Val  Lys Val Pro 
    1145                 1150                 1155             


Val Cys  Leu Thr Ser Ala Val  Pro Asp Cys Gly Gln  Leu Pro Glu 
    1160                 1165                 1170             


Glu Ser  Val Lys Asp Asn Val  Glu Pro Val Pro Thr  Gln Arg Thr 
    1175                 1180                 1185             


Cys Cys  Gln Asp Ile Val Asn  Asp Val Ser Ser Asp  Gly Ser Glu 
    1190                 1195                 1200             


Asp Pro  Ala Glu Phe Ser Arg  Gly Asp Ser Cys Ala  His Ser Glu 
    1205                 1210                 1215             


Thr Glu  Ile Asn Ile Val Ser  Trp Asn Ala Leu Ile  Leu Pro Pro 
    1220                 1225                 1230             


Val Pro  Glu Gly Cys Ala Glu  Lys Thr Met Trp Ser  Pro Pro Gly 
    1235                 1240                 1245             


Ile Pro  Leu Asp Ser Pro Thr  Glu Val Leu Gln Gln  Pro Arg Glu 
    1250                 1255                 1260             


Thr 
    


<210>  4282
<211>  666
<212>  PRT
<213>  Homo sapiens

<400>  4282

Met Ala Met Thr Trp Ile Val Phe Ser Leu Trp Pro Leu Thr Val Phe 
1               5                   10                  15      


Met Gly His Ile Gly Gly His Ser Leu Phe Ser Cys Glu Pro Ile Thr 
            20                  25                  30          


Leu Arg Met Cys Gln Asp Leu Pro Tyr Asn Thr Thr Phe Met Pro Asn 
        35                  40                  45              


Leu Leu Asn His Tyr Asp Gln Gln Thr Ala Ala Leu Ala Met Glu Pro 
    50                  55                  60                  


Phe His Pro Met Val Asn Leu Asp Cys Ser Arg Asp Phe Arg Pro Phe 
65                  70                  75                  80  


Leu Cys Ala Leu Tyr Ala Pro Ile Cys Met Glu Tyr Gly Arg Val Thr 
                85                  90                  95      


Leu Pro Cys Arg Arg Leu Cys Gln Arg Ala Tyr Ser Glu Cys Ser Lys 
            100                 105                 110         


Leu Met Glu Met Phe Gly Val Pro Trp Pro Glu Asp Met Glu Cys Ser 
        115                 120                 125             


Arg Phe Pro Asp Cys Asp Glu Pro Tyr Pro Arg Leu Val Asp Leu Asn 
    130                 135                 140                 


Leu Ala Gly Glu Pro Thr Glu Gly Ala Pro Val Ala Val Gln Arg Asp 
145                 150                 155                 160 


Tyr Gly Phe Trp Cys Pro Arg Glu Leu Lys Ile Asp Pro Asp Leu Gly 
                165                 170                 175     


Tyr Ser Phe Leu His Val Arg Asp Cys Ser Pro Pro Cys Pro Asn Met 
            180                 185                 190         


Tyr Phe Arg Arg Glu Glu Leu Ser Phe Ala Arg Tyr Phe Ile Gly Leu 
        195                 200                 205             


Ile Ser Ile Ile Cys Leu Ser Ala Thr Leu Phe Thr Phe Leu Thr Phe 
    210                 215                 220                 


Leu Ile Asp Val Thr Arg Phe Arg Tyr Pro Glu Arg Pro Ile Ile Phe 
225                 230                 235                 240 


Tyr Ala Val Cys Tyr Met Met Val Ser Leu Ile Phe Phe Ile Gly Phe 
                245                 250                 255     


Leu Leu Glu Asp Arg Val Ala Cys Asn Ala Ser Ile Pro Ala Gln Tyr 
            260                 265                 270         


Lys Ala Ser Thr Val Thr Gln Gly Ser His Asn Lys Ala Cys Thr Met 
        275                 280                 285             


Leu Phe Met Ile Leu Tyr Phe Phe Thr Met Ala Gly Ser Val Trp Trp 
    290                 295                 300                 


Val Ile Leu Thr Ile Thr Trp Phe Leu Ala Ala Val Pro Lys Trp Gly 
305                 310                 315                 320 


Ser Glu Ala Ile Glu Lys Lys Ala Leu Leu Phe His Ala Ser Ala Trp 
                325                 330                 335     


Gly Ile Pro Gly Thr Leu Thr Ile Ile Leu Leu Ala Met Asn Lys Ile 
            340                 345                 350         


Glu Gly Asp Asn Ile Ser Gly Val Cys Phe Val Gly Leu Tyr Asp Val 
        355                 360                 365             


Asp Ala Leu Arg Tyr Phe Val Leu Ala Pro Leu Cys Leu Tyr Val Val 
    370                 375                 380                 


Val Gly Val Ser Leu Leu Leu Ala Gly Ile Ile Ser Leu Asn Arg Val 
385                 390                 395                 400 


Arg Ile Glu Ile Pro Leu Glu Lys Glu Asn Gln Asp Lys Leu Val Lys 
                405                 410                 415     


Phe Met Ile Arg Ile Gly Val Phe Ser Ile Leu Tyr Leu Val Pro Leu 
            420                 425                 430         


Leu Val Val Ile Gly Cys Tyr Phe Tyr Glu Gln Ala Tyr Arg Gly Ile 
        435                 440                 445             


Trp Glu Thr Thr Trp Ile Gln Glu Arg Cys Arg Glu Tyr His Ile Pro 
    450                 455                 460                 


Cys Pro Tyr Gln Val Thr Gln Met Ser Arg Pro Asp Leu Ile Leu Phe 
465                 470                 475                 480 


Leu Met Lys Tyr Leu Met Ala Leu Ile Val Gly Ile Pro Ser Val Phe 
                485                 490                 495     


Trp Val Gly Ser Lys Lys Thr Cys Phe Glu Trp Ala Ser Phe Phe His 
            500                 505                 510         


Gly Arg Arg Lys Lys Glu Ile Val Asn Glu Ser Arg Gln Val Leu Gln 
        515                 520                 525             


Glu Pro Asp Phe Ala Gln Ser Leu Leu Arg Asp Pro Asn Thr Pro Ile 
    530                 535                 540                 


Ile Arg Lys Ser Arg Gly Thr Ser Thr Gln Gly Thr Ser Thr His Ala 
545                 550                 555                 560 


Ser Ser Thr Gln Leu Ala Met Val Asp Asp Gln Arg Ser Lys Ala Gly 
                565                 570                 575     


Ser Ile His Ser Lys Val Ser Ser Tyr His Gly Ser Leu His Arg Ser 
            580                 585                 590         


Arg Asp Gly Arg Tyr Thr Pro Cys Ser Tyr Arg Gly Met Glu Glu Arg 
        595                 600                 605             


Leu Pro His Gly Ser Met Ser Arg Leu Thr Asp His Ser Arg His Ser 
    610                 615                 620                 


Ser Ser His Arg Leu Asn Glu Gln Ser Arg His Ser Ser Ile Arg Asp 
625                 630                 635                 640 


Leu Ser Asn Asn Pro Met Thr His Ile Thr His Gly Thr Ser Met Asn 
                645                 650                 655     


Arg Val Ile Glu Glu Asp Gly Thr Ser Ala 
            660                 665     


<210>  4283
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  4283

Met Asn Leu Arg Leu Cys Val Gln Ala Leu Leu Leu Leu Trp Leu Ser 
1               5                   10                  15      


Leu Thr Ala Val Cys Gly Gly Ser Leu Met Pro Leu Pro Asp Gly Asn 
            20                  25                  30          


Gly Leu Glu Asp Gly Asn Val Arg His Leu Val Gln Pro Arg Gly Ser 
        35                  40                  45              


Arg Asn Gly Pro Gly Pro Trp Gln Gly Gly Arg Arg Lys Phe Arg Arg 
    50                  55                  60                  


Gln Arg Pro Arg Leu Ser His Lys Gly Pro Met Pro Phe 
65                  70                  75          


<210>  4284
<211>  686
<212>  PRT
<213>  Homo sapiens

<400>  4284

Met Lys Pro Pro Phe Leu Leu Ala Leu Val Val Cys Ser Val Val Ser 
1               5                   10                  15      


Thr Asn Leu Lys Met Val Ser Lys Arg Asn Ser Val Asp Gly Cys Ile 
            20                  25                  30          


Asp Trp Ser Val Asp Leu Lys Thr Tyr Met Ala Leu Ala Gly Glu Pro 
        35                  40                  45              


Val Arg Val Lys Cys Ala Leu Phe Tyr Ser Tyr Ile Arg Thr Asn Tyr 
    50                  55                  60                  


Ser Thr Ala Gln Ser Thr Gly Leu Arg Leu Met Trp Tyr Lys Asn Lys 
65                  70                  75                  80  


Gly Asp Leu Glu Glu Pro Ile Ile Phe Ser Glu Val Arg Met Ser Lys 
                85                  90                  95      


Glu Glu Asp Ser Ile Trp Phe His Ser Ala Glu Ala Gln Asp Ser Gly 
            100                 105                 110         


Phe Tyr Thr Cys Val Leu Arg Asn Ser Thr Tyr Cys Met Lys Val Ser 
        115                 120                 125             


Met Ser Leu Thr Val Ala Glu Asn Glu Ser Gly Leu Cys Tyr Asn Ser 
    130                 135                 140                 


Arg Ile Arg Tyr Leu Glu Lys Ser Glu Val Thr Lys Arg Lys Glu Ile 
145                 150                 155                 160 


Ser Cys Pro Asp Met Asp Asp Phe Lys Lys Ser Asp Gln Glu Pro Asp 
                165                 170                 175     


Val Val Trp Tyr Lys Glu Cys Lys Pro Lys Met Trp Arg Ser Ile Ile 
            180                 185                 190         


Ile Gln Lys Gly Asn Ala Leu Leu Ile Gln Glu Val Gln Glu Glu Asp 
        195                 200                 205             


Gly Gly Asn Tyr Thr Cys Glu Leu Lys Tyr Glu Gly Lys Leu Val Arg 
    210                 215                 220                 


Arg Thr Thr Glu Leu Lys Val Thr Ala Leu Leu Thr Asp Lys Pro Pro 
225                 230                 235                 240 


Lys Pro Leu Phe Pro Met Glu Asn Gln Pro Ser Val Ile Asp Val Gln 
                245                 250                 255     


Leu Gly Lys Pro Leu Asn Ile Pro Cys Lys Ala Phe Phe Gly Phe Ser 
            260                 265                 270         


Gly Glu Ser Gly Pro Met Ile Tyr Trp Met Lys Gly Glu Lys Phe Ile 
        275                 280                 285             


Glu Glu Leu Ala Gly His Ile Arg Glu Gly Glu Ile Arg Leu Leu Lys 
    290                 295                 300                 


Glu His Leu Gly Glu Lys Glu Val Glu Leu Ala Leu Ile Phe Asp Ser 
305                 310                 315                 320 


Val Val Glu Ala Asp Leu Ala Asn Tyr Thr Cys His Val Glu Asn Arg 
                325                 330                 335     


Asn Gly Arg Lys His Ala Ser Val Leu Leu Arg Lys Lys Asp Leu Ile 
            340                 345                 350         


Tyr Lys Ile Glu Leu Ala Gly Gly Leu Gly Ala Ile Phe Leu Leu Leu 
        355                 360                 365             


Val Leu Leu Val Val Ile Tyr Lys Cys Tyr Asn Ile Glu Leu Met Leu 
    370                 375                 380                 


Phe Tyr Arg Gln His Phe Gly Ala Asp Glu Thr Asn Asp Asp Asn Lys 
385                 390                 395                 400 


Glu Tyr Asp Ala Tyr Leu Ser Tyr Thr Lys Val Asp Gln Asp Thr Leu 
                405                 410                 415     


Asp Cys Asp Asn Pro Glu Glu Glu Gln Phe Ala Leu Glu Val Leu Pro 
            420                 425                 430         


Asp Val Leu Glu Lys His Tyr Gly Tyr Lys Leu Phe Ile Pro Glu Arg 
        435                 440                 445             


Asp Leu Ile Pro Ser Gly Thr Tyr Met Glu Asp Leu Thr Arg Tyr Val 
    450                 455                 460                 


Glu Gln Ser Arg Arg Leu Ile Ile Val Leu Thr Pro Asp Tyr Ile Leu 
465                 470                 475                 480 


Arg Arg Gly Trp Ser Ile Phe Glu Leu Glu Ser Arg Leu His Asn Met 
                485                 490                 495     


Leu Val Ser Gly Glu Ile Lys Val Ile Leu Ile Glu Cys Thr Glu Leu 
            500                 505                 510         


Lys Gly Lys Val Asn Cys Gln Glu Val Glu Ser Leu Lys Arg Ser Ile 
        515                 520                 525             


Lys Leu Leu Ser Leu Ile Lys Trp Lys Gly Ser Lys Ser Ser Lys Leu 
    530                 535                 540                 


Asn Ser Lys Phe Trp Lys His Leu Val Tyr Glu Met Pro Ile Lys Lys 
545                 550                 555                 560 


Lys Glu Met Leu Pro Arg Cys His Val Leu Asp Ser Ala Glu Gln Gly 
                565                 570                 575     


Leu Phe Gly Glu Leu Gln Pro Ile Pro Ser Ile Ala Met Thr Ser Thr 
            580                 585                 590         


Ser Ala Thr Leu Val Ser Ser Gln Ala Asp Leu Pro Glu Phe His Pro 
        595                 600                 605             


Ser Asp Ser Met Gln Ile Arg His Cys Cys Arg Gly Tyr Lys His Glu 
    610                 615                 620                 


Ile Pro Ala Thr Thr Leu Pro Val Pro Ser Leu Gly Asn His His Thr 
625                 630                 635                 640 


Tyr Cys Asn Leu Pro Leu Thr Leu Leu Asn Gly Gln Leu Pro Leu Asn 
                645                 650                 655     


Asn Thr Leu Lys Asp Thr Gln Glu Phe His Arg Asn Ser Ser Leu Leu 
            660                 665                 670         


Pro Leu Ser Ser Lys Glu Leu Ser Phe Thr Ser Asp Ile Trp 
        675                 680                 685     


<210>  4285
<211>  637
<212>  PRT
<213>  Homo sapiens

<400>  4285

Met Met Phe Trp Arg Lys Leu Pro Lys Ala Leu Phe Ile Gly Leu Thr 
1               5                   10                  15      


Leu Ala Ile Ala Val Asn Leu Leu Leu Val Phe Ser Ser Lys Gly Thr 
            20                  25                  30          


Leu Gln Asn Leu Phe Thr Gly Gly Leu His Arg Glu Leu Pro Leu His 
        35                  40                  45              


Leu Asn Lys Arg Tyr Gly Ala Val Ile Lys Arg Leu Ser His Leu Glu 
    50                  55                  60                  


Val Glu Leu Gln Asp Leu Lys Glu Ser Met Lys Leu Ala Leu Arg Gln 
65                  70                  75                  80  


Gln Glu Asn Val Asn Ser Thr Leu Lys Arg Ala Lys Asp Glu Val Arg 
                85                  90                  95      


Pro Leu Leu Lys Ala Met Glu Thr Lys Val Asn Glu Thr Lys Lys His 
            100                 105                 110         


Lys Thr Gln Met Lys Leu Phe Pro His Ser Gln Leu Phe Arg Gln Trp 
        115                 120                 125             


Gly Glu Asp Leu Ser Glu Ala Gln Gln Lys Ala Ala Gln Asp Leu Phe 
    130                 135                 140                 


Arg Lys Phe Gly Tyr Asn Ala Tyr Leu Ser Asn Gln Leu Pro Leu Asn 
145                 150                 155                 160 


Arg Thr Ile Pro Asp Thr Arg Asp Tyr Arg Cys Leu Arg Lys Thr Tyr 
                165                 170                 175     


Pro Ser Gln Leu Pro Ser Leu Ser Val Ile Leu Ile Phe Val Asn Glu 
            180                 185                 190         


Ala Leu Ser Ile Ile Gln Arg Ala Ile Thr Ser Ile Ile Asn Arg Thr 
        195                 200                 205             


Pro Ser Arg Leu Leu Lys Glu Ile Ile Leu Val Asp Asp Phe Ser Ser 
    210                 215                 220                 


Asn Gly Glu Leu Lys Val His Leu Asp Glu Lys Ile Lys Leu Tyr Asn 
225                 230                 235                 240 


Gln Lys Tyr Pro Gly Leu Leu Lys Ile Ile Arg His Pro Glu Arg Lys 
                245                 250                 255     


Gly Leu Ala Gln Ala Arg Asn Thr Gly Trp Glu Ala Ala Thr Ala Asp 
            260                 265                 270         


Val Val Ala Ile Leu Asp Ala His Ile Glu Val Asn Val Gly Trp Ala 
        275                 280                 285             


Glu Pro Ile Leu Ala Arg Ile Gln Glu Asp Arg Thr Val Ile Val Ser 
    290                 295                 300                 


Pro Val Phe Asp Asn Ile Arg Phe Asp Thr Phe Lys Leu Asp Lys Tyr 
305                 310                 315                 320 


Glu Leu Ala Val Asp Gly Phe Asn Trp Glu Leu Trp Cys Arg Tyr Asp 
                325                 330                 335     


Ala Leu Pro Gln Ala Trp Ile Asp Leu His Asp Val Thr Ala Pro Val 
            340                 345                 350         


Lys Ser Pro Ser Ile Met Gly Ile Leu Ala Ala Asn Arg His Phe Leu 
        355                 360                 365             


Gly Glu Ile Gly Ser Leu Asp Gly Gly Met Leu Ile Tyr Gly Gly Glu 
    370                 375                 380                 


Asn Val Glu Leu Ser Leu Arg Val Trp Gln Cys Gly Gly Lys Val Glu 
385                 390                 395                 400 


Ile Leu Pro Cys Ser Arg Ile Ala His Leu Glu Arg His His Lys Pro 
                405                 410                 415     


Tyr Ala Leu Asp Leu Thr Ala Ala Leu Lys Arg Asn Ala Leu Arg Val 
            420                 425                 430         


Ala Glu Ile Trp Met Asp Glu His Lys His Met Val Tyr Leu Ala Trp 
        435                 440                 445             


Asn Ile Pro Leu Gln Asn Ser Gly Ile Asp Phe Gly Asp Val Ser Ser 
    450                 455                 460                 


Arg Met Ala Leu Arg Glu Lys Leu Lys Cys Lys Thr Phe Asp Trp Tyr 
465                 470                 475                 480 


Leu Lys Asn Val Tyr Pro Leu Leu Lys Pro Leu His Thr Ile Val Gly 
                485                 490                 495     


Tyr Gly Arg Met Lys Asn Leu Leu Asp Glu Asn Val Cys Leu Asp Gln 
            500                 505                 510         


Gly Pro Val Pro Gly Asn Thr Pro Ile Met Tyr Tyr Cys His Glu Phe 
        515                 520                 525             


Ser Ser Gln Asn Val Tyr Tyr His Leu Thr Gly Glu Leu Tyr Val Gly 
    530                 535                 540                 


Gln Leu Ile Ala Glu Ala Ser Ala Ser Asp Arg Cys Leu Thr Asp Pro 
545                 550                 555                 560 


Gly Lys Ala Glu Lys Pro Thr Leu Glu Pro Cys Ser Lys Ala Ala Lys 
                565                 570                 575     


Asn Arg Leu His Ile Tyr Trp Asp Phe Lys Pro Gly Gly Ala Val Ile 
            580                 585                 590         


Asn Arg Asp Thr Lys Arg Cys Leu Glu Met Lys Lys Asp Leu Leu Gly 
        595                 600                 605             


Ser His Val Leu Val Leu Gln Thr Cys Ser Thr Gln Val Trp Glu Ile 
    610                 615                 620                 


Gln His Thr Val Arg Asp Trp Gly Gln Thr Asn Ser Gln 
625                 630                 635         


<210>  4286
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  4286

Met Glu Gln Thr Glu Lys Ser Lys Val Tyr Ala Glu Asn Gly Leu Leu 
1               5                   10                  15      


Glu Lys Ile Lys Leu Cys Leu Ser Lys Lys Pro Leu Pro Ser Pro Thr 
            20                  25                  30          


Glu Arg Lys Lys Phe Asp His Asp Phe Ala Ile Ser Thr Ser Phe His 
        35                  40                  45              


Gly Ile His Asn Ile Val Gln Asn Arg Ser Lys Ile Arg Arg Val Leu 
    50                  55                  60                  


Trp Leu Val Val Val Leu Gly Ser Val Ser Leu Val Thr Trp Gln Ile 
65                  70                  75                  80  


Tyr Ile Arg Leu Leu Asn Tyr Phe Thr Trp Pro Thr Thr Thr Ser Ile 
                85                  90                  95      


Glu Val Gln Tyr Val Glu Lys Met Glu Phe Pro Ala Val Thr Phe Cys 
            100                 105                 110         


Asn Leu Asn Arg Phe Gln Thr Asp Ala Val Ala Lys Phe Gly Val Ile 
        115                 120                 125             


Phe Phe Leu Trp His Ile Val Ser Lys Val Leu His Leu Gln Glu Ile 
    130                 135                 140                 


Thr Ala Asn Ser Thr Gly Ser Arg Glu Ala Thr Asp Phe Ala Ala Ser 
145                 150                 155                 160 


His Gln Asn Phe Ser Ile Val Glu Phe Ile Arg Asn Lys Gly Phe Tyr 
                165                 170                 175     


Leu Asn Asn Ser Thr Leu Leu Asp Cys Glu Phe Phe Gly Lys Pro Cys 
            180                 185                 190         


Ser Pro Lys Asp Phe Ala His Val Phe Thr Glu Tyr Gly Asn Cys Phe 
        195                 200                 205             


Thr Phe Asn His Gly Glu Thr Leu Gln Ala Lys Arg Lys Val Ser Val 
    210                 215                 220                 


Ser Gly Arg Gly Leu Ser Leu Leu Phe Asn Val Asn Gln Glu Ala Phe 
225                 230                 235                 240 


Thr Asp Asn Pro Ala Leu Gly Phe Val Asp Ala Gly Ile Ile Phe Val 
                245                 250                 255     


Ile His Ser Pro Lys Lys Val Pro Gln Phe Asp Gly Leu Gly Leu Leu 
            260                 265                 270         


Ser Pro Val Gly Met His Ala Arg Val Thr Ile Arg Gln Val Lys Thr 
        275                 280                 285             


Val His Gln Glu Tyr Pro Trp Gly Glu Cys Asn Pro Asn Ile Lys Leu 
    290                 295                 300                 


Gln Asn Phe Ser Ser Tyr Ser Thr Ser Gly Cys Leu Lys Glu Cys Lys 
305                 310                 315                 320 


Ala Gln His Ile Lys Lys Gln Cys Gly Cys Val Pro Phe Leu Leu Pro 
                325                 330                 335     


Gly Tyr Gly Ile Glu Cys Asp Leu Gln Lys Tyr Phe Ser Cys Val Ser 
            340                 345                 350         


Pro Val Leu Asp His Ile Glu Phe Lys Asp Leu Cys Thr Val Gly Thr 
        355                 360                 365             


His Asn Ser Ser Cys Pro Val Ser Cys Glu Glu Ile Glu Tyr Pro Ala 
    370                 375                 380                 


Thr Ile Ser Tyr Ser Ser Phe Pro Ser Gln Lys Ala Leu Lys Tyr Leu 
385                 390                 395                 400 


Ser Lys Lys Leu Asn Gln Ser Arg Lys Tyr Ile Arg Glu Asn Leu Val 
                405                 410                 415     


Lys Ile Glu Ile Asn Tyr Ser Asp Leu Asn Tyr Lys Ile Thr Gln Gln 
            420                 425                 430         


Gln Lys Ala Val Ser Val Ser Glu Leu Leu Ala Asp Leu Gly Gly Gln 
        435                 440                 445             


Leu Gly Leu Phe Cys Gly Ala Ser Leu Ile Thr Ile Ile Glu Ile Ile 
    450                 455                 460                 


Glu Tyr Leu Phe Thr Asn Phe Tyr Trp Ile Cys Ile Phe Phe Leu Leu 
465                 470                 475                 480 


Lys Ile Ser Glu Met Thr Gln Trp Thr Pro Pro Pro Gln Asn His Leu 
                485                 490                 495     


Gly Asn Lys Asn Arg Ile Glu Glu Cys 
            500                 505 


<210>  4287
<211>  657
<212>  PRT
<213>  Homo sapiens

<400>  4287

Met Arg Leu Lys Ile Gly Phe Ile Leu Arg Ser Leu Leu Val Val Gly 
1               5                   10                  15      


Ser Phe Leu Gly Leu Val Val Leu Trp Ser Ser Leu Thr Pro Arg Pro 
            20                  25                  30          


Asp Asp Pro Ser Pro Leu Ser Arg Met Arg Glu Asp Arg Asp Val Asn 
        35                  40                  45              


Asp Pro Met Pro Asn Arg Gly Gly Asn Gly Leu Ala Pro Gly Glu Asp 
    50                  55                  60                  


Arg Phe Lys Pro Val Val Pro Trp Pro His Val Glu Gly Val Glu Val 
65                  70                  75                  80  


Asp Leu Glu Ser Ile Arg Arg Ile Asn Lys Ala Lys Asn Glu Gln Glu 
                85                  90                  95      


His His Ala Gly Gly Asp Ser Gln Lys Asp Ile Met Gln Arg Gln Tyr 
            100                 105                 110         


Leu Thr Phe Lys Pro Gln Thr Phe Thr Tyr His Asp Pro Val Leu Arg 
        115                 120                 125             


Pro Gly Ile Leu Gly Asn Phe Glu Pro Lys Glu Pro Glu Pro Pro Gly 
    130                 135                 140                 


Val Val Gly Gly Pro Gly Glu Lys Ala Lys Pro Leu Val Leu Gly Pro 
145                 150                 155                 160 


Glu Phe Lys Gln Ala Ile Gln Ala Ser Ile Lys Glu Phe Gly Phe Asn 
                165                 170                 175     


Met Val Ala Ser Asp Met Ile Ser Leu Asp Arg Ser Val Asn Asp Leu 
            180                 185                 190         


Arg Gln Glu Glu Cys Lys Tyr Trp His Tyr Asp Glu Asn Leu Leu Thr 
        195                 200                 205             


Ser Ser Val Val Ile Val Phe His Asn Glu Gly Trp Ser Thr Leu Met 
    210                 215                 220                 


Arg Thr Val His Ser Val Ile Lys Arg Thr Pro Arg Lys Tyr Leu Ala 
225                 230                 235                 240 


Glu Ile Val Leu Ile Asp Asp Phe Ser Asn Lys Glu His Leu Lys Glu 
                245                 250                 255     


Lys Leu Asp Glu Tyr Ile Lys Leu Trp Asn Gly Leu Val Lys Val Phe 
            260                 265                 270         


Arg Asn Glu Arg Arg Glu Gly Leu Ile Gln Ala Arg Ser Ile Gly Ala 
        275                 280                 285             


Gln Lys Ala Lys Leu Gly Gln Val Leu Ile Tyr Leu Asp Ala His Cys 
    290                 295                 300                 


Glu Val Ala Val Asn Trp Tyr Ala Pro Leu Val Ala Pro Ile Ser Lys 
305                 310                 315                 320 


Asp Arg Thr Ile Cys Thr Val Pro Leu Ile Asp Val Ile Asn Gly Asn 
                325                 330                 335     


Thr Tyr Glu Ile Ile Pro Gln Gly Gly Gly Asp Glu Asp Gly Tyr Ala 
            340                 345                 350         


Arg Gly Ala Trp Asp Trp Ser Met Leu Trp Lys Arg Val Pro Leu Thr 
        355                 360                 365             


Pro Gln Glu Lys Arg Leu Arg Lys Thr Lys Thr Glu Pro Tyr Arg Ser 
    370                 375                 380                 


Pro Ala Met Ala Gly Gly Leu Phe Ala Ile Glu Arg Glu Phe Phe Phe 
385                 390                 395                 400 


Glu Leu Gly Leu Tyr Asp Pro Gly Leu Gln Ile Trp Gly Gly Glu Asn 
                405                 410                 415     


Phe Glu Ile Ser Tyr Lys Ile Trp Gln Cys Gly Gly Lys Leu Leu Phe 
            420                 425                 430         


Val Pro Cys Ser Arg Val Gly His Ile Tyr Arg Leu Glu Gly Trp Gln 
        435                 440                 445             


Gly Asn Pro Pro Pro Ile Tyr Val Gly Ser Ser Pro Thr Leu Lys Asn 
    450                 455                 460                 


Tyr Val Arg Val Val Glu Val Trp Trp Asp Glu Tyr Lys Asp Tyr Phe 
465                 470                 475                 480 


Tyr Ala Ser Arg Pro Glu Ser Gln Ala Leu Pro Tyr Gly Asp Ile Ser 
                485                 490                 495     


Glu Leu Lys Lys Phe Arg Glu Asp His Asn Cys Lys Ser Phe Lys Trp 
            500                 505                 510         


Phe Met Glu Glu Ile Ala Tyr Asp Ile Thr Ser His Tyr Pro Leu Pro 
        515                 520                 525             


Pro Lys Asn Val Asp Trp Gly Glu Ile Arg Gly Phe Glu Thr Ala Tyr 
    530                 535                 540                 


Cys Ile Asp Ser Met Gly Lys Thr Asn Gly Gly Phe Val Glu Leu Gly 
545                 550                 555                 560 


Pro Cys His Arg Met Gly Gly Asn Gln Leu Phe Arg Ile Asn Glu Ala 
                565                 570                 575     


Asn Gln Leu Met Gln Tyr Asp Gln Cys Leu Thr Lys Gly Ala Asp Gly 
            580                 585                 590         


Ser Lys Val Met Ile Thr His Cys Asn Leu Asn Glu Phe Lys Glu Trp 
        595                 600                 605             


Gln Tyr Phe Lys Asn Leu His Arg Phe Thr His Ile Pro Ser Gly Lys 
    610                 615                 620                 


Cys Leu Asp Arg Ser Glu Val Leu His Gln Val Phe Ile Ser Asn Cys 
625                 630                 635                 640 


Asp Ser Ser Lys Thr Thr Gln Lys Trp Glu Met Asn Asn Ile His Ser 
                645                 650                 655     


Val 
    


<210>  4288
<211>  511
<212>  PRT
<213>  Homo sapiens

<400>  4288

Met Leu Val Asp Gly Pro Ser Glu Arg Pro Ala Leu Cys Phe Leu Leu 
1               5                   10                  15      


Leu Ala Val Ala Met Ser Phe Phe Gly Ser Ala Leu Ser Ile Asp Glu 
            20                  25                  30          


Thr Arg Ala His Leu Leu Leu Lys Glu Lys Met Met Arg Leu Gly Gly 
        35                  40                  45              


Arg Leu Val Leu Asn Thr Lys Glu Glu Leu Ala Asn Glu Arg Leu Met 
    50                  55                  60                  


Thr Leu Lys Ile Ala Glu Met Lys Glu Ala Met Arg Thr Leu Ile Phe 
65                  70                  75                  80  


Pro Pro Ser Met His Phe Phe Gln Ala Lys His Leu Ile Glu Arg Ser 
                85                  90                  95      


Gln Val Phe Asn Ile Leu Arg Met Met Pro Lys Gly Ala Ala Leu His 
            100                 105                 110         


Leu His Asp Ile Gly Ile Val Thr Met Asp Trp Leu Val Arg Asn Val 
        115                 120                 125             


Thr Tyr Arg Pro His Cys His Ile Cys Phe Thr Pro Arg Gly Ile Met 
    130                 135                 140                 


Gln Phe Arg Phe Ala His Pro Thr Pro Arg Pro Ser Glu Lys Cys Ser 
145                 150                 155                 160 


Lys Trp Ile Leu Leu Glu Asp Tyr Arg Lys Arg Val Gln Asn Val Thr 
                165                 170                 175     


Glu Phe Asp Asp Ser Leu Leu Arg Asn Phe Thr Leu Val Thr Gln His 
            180                 185                 190         


Pro Glu Val Ile Tyr Thr Asn Gln Asn Val Val Trp Ser Lys Phe Glu 
        195                 200                 205             


Thr Ile Phe Phe Thr Ile Ser Gly Leu Ile His Tyr Ala Pro Val Phe 
    210                 215                 220                 


Arg Asp Tyr Val Phe Arg Ser Met Gln Glu Phe Tyr Glu Asp Asn Val 
225                 230                 235                 240 


Leu Tyr Met Glu Ile Arg Ala Arg Leu Leu Pro Val Tyr Glu Leu Ser 
                245                 250                 255     


Gly Glu His His Asp Glu Glu Trp Ser Val Lys Thr Tyr Gln Glu Val 
            260                 265                 270         


Ala Gln Lys Phe Val Glu Thr His Pro Glu Phe Ile Gly Ile Lys Ile 
        275                 280                 285             


Ile Tyr Ser Asp His Arg Ser Lys Asp Val Ala Val Ile Ala Glu Ser 
    290                 295                 300                 


Ile Arg Met Ala Met Gly Leu Arg Ile Lys Phe Pro Thr Val Val Ala 
305                 310                 315                 320 


Gly Phe Asp Leu Val Gly His Glu Asp Thr Gly His Ser Leu His Asp 
                325                 330                 335     


Tyr Lys Glu Ala Leu Met Ile Pro Ala Lys Asp Gly Val Lys Leu Pro 
            340                 345                 350         


Tyr Phe Phe His Ala Gly Glu Thr Asp Trp Gln Gly Thr Ser Ile Asp 
        355                 360                 365             


Arg Asn Ile Leu Asp Ala Leu Met Leu Asn Thr Thr Arg Ile Gly His 
    370                 375                 380                 


Gly Phe Ala Leu Ser Lys His Pro Ala Val Arg Thr Tyr Ser Trp Lys 
385                 390                 395                 400 


Lys Asp Ile Pro Ile Glu Val Cys Pro Ile Ser Asn Gln Val Leu Lys 
                405                 410                 415     


Leu Val Ser Asp Leu Arg Asn His Pro Val Ala Thr Leu Met Ala Thr 
            420                 425                 430         


Gly His Pro Met Val Ile Ser Ser Asp Asp Pro Ala Met Phe Gly Ala 
        435                 440                 445             


Lys Gly Leu Ser Tyr Asp Phe Tyr Glu Val Phe Met Gly Ile Gly Gly 
    450                 455                 460                 


Met Lys Ala Asp Leu Arg Thr Leu Lys Gln Leu Ala Met Asn Ser Ile 
465                 470                 475                 480 


Lys Tyr Ser Thr Leu Leu Glu Ser Glu Lys Asn Thr Phe Met Glu Ile 
                485                 490                 495     


Trp Lys Lys Arg Trp Asp Lys Phe Ile Ala Asp Val Ala Thr Lys 
            500                 505                 510     


<210>  4289
<211>  1551
<212>  PRT
<213>  Homo sapiens

<400>  4289

Met Gly Phe Cys Leu Ala Leu Ala Trp Thr Leu Leu Val Gly Ala Trp 
1               5                   10                  15      


Thr Pro Leu Gly Ala Gln Asn Pro Ile Ser Trp Glu Val Gln Arg Phe 
            20                  25                  30          


Asp Gly Trp Tyr Asn Asn Leu Met Glu His Arg Trp Gly Ser Lys Gly 
        35                  40                  45              


Ser Arg Leu Gln Arg Leu Val Pro Ala Ser Tyr Ala Asp Gly Val Tyr 
    50                  55                  60                  


Gln Pro Leu Gly Glu Pro His Leu Pro Asn Pro Arg Asp Leu Ser Asn 
65                  70                  75                  80  


Thr Ile Ser Arg Gly Pro Ala Gly Leu Ala Ser Leu Arg Asn Arg Thr 
                85                  90                  95      


Val Leu Gly Val Phe Phe Gly Tyr His Val Leu Ser Asp Leu Val Ser 
            100                 105                 110         


Val Glu Thr Pro Gly Cys Pro Ala Glu Phe Leu Asn Ile Arg Ile Pro 
        115                 120                 125             


Pro Gly Asp Pro Met Phe Asp Pro Asp Gln Arg Gly Asp Val Val Leu 
    130                 135                 140                 


Pro Phe Gln Arg Ser Arg Trp Asp Pro Glu Thr Gly Arg Ser Pro Ser 
145                 150                 155                 160 


Asn Pro Arg Asp Pro Ala Asn Gln Val Thr Gly Trp Leu Asp Gly Ser 
                165                 170                 175     


Ala Ile Tyr Gly Ser Ser His Ser Trp Ser Asp Ala Leu Arg Ser Phe 
            180                 185                 190         


Ser Arg Gly Gln Leu Ala Ser Gly Pro Asp Pro Ala Phe Pro Arg Asp 
        195                 200                 205             


Ser Gln Asn Pro Leu Leu Met Trp Ala Ala Pro Asp Pro Ala Thr Gly 
    210                 215                 220                 


Gln Asn Gly Pro Arg Gly Leu Tyr Ala Phe Gly Ala Glu Arg Gly Asn 
225                 230                 235                 240 


Arg Glu Pro Phe Leu Gln Ala Leu Gly Leu Leu Trp Phe Arg Tyr His 
                245                 250                 255     


Asn Leu Trp Ala Gln Arg Leu Ala Arg Gln His Pro Asp Trp Glu Asp 
            260                 265                 270         


Glu Glu Leu Phe Gln His Ala Arg Lys Arg Val Ile Ala Thr Tyr Gln 
        275                 280                 285             


Asn Ile Ala Val Tyr Glu Trp Leu Pro Ser Phe Leu Gln Lys Thr Leu 
    290                 295                 300                 


Pro Glu Tyr Thr Gly Tyr Arg Pro Phe Leu Asp Pro Ser Ile Ser Ser 
305                 310                 315                 320 


Glu Phe Val Ala Ala Ser Glu Gln Phe Leu Ser Thr Met Val Pro Pro 
                325                 330                 335     


Gly Val Tyr Met Arg Asn Ala Ser Cys His Phe Gln Gly Val Ile Asn 
            340                 345                 350         


Arg Asn Ser Ser Val Ser Arg Ala Leu Arg Val Cys Asn Ser Tyr Trp 
        355                 360                 365             


Ser Arg Glu His Pro Ser Leu Gln Ser Ala Glu Asp Val Asp Ala Leu 
    370                 375                 380                 


Leu Leu Gly Met Ala Ser Gln Ile Ala Glu Arg Glu Asp His Val Leu 
385                 390                 395                 400 


Val Glu Asp Val Arg Asp Phe Trp Pro Gly Pro Leu Lys Phe Ser Arg 
                405                 410                 415     


Thr Asp His Leu Ala Ser Cys Leu Gln Arg Gly Arg Asp Leu Gly Leu 
            420                 425                 430         


Pro Ser Tyr Thr Lys Ala Arg Ala Ala Leu Gly Leu Ser Pro Ile Thr 
        435                 440                 445             


Arg Trp Gln Asp Ile Asn Pro Ala Leu Ser Arg Ser Asn Asp Thr Val 
    450                 455                 460                 


Leu Glu Ala Thr Ala Ala Leu Tyr Asn Gln Asp Leu Ser Trp Leu Glu 
465                 470                 475                 480 


Leu Leu Pro Gly Gly Leu Leu Glu Ser His Arg Asp Pro Gly Pro Leu 
                485                 490                 495     


Phe Ser Thr Ile Val Leu Glu Gln Phe Val Arg Leu Arg Asp Gly Asp 
            500                 505                 510         


Arg Tyr Trp Phe Glu Asn Thr Arg Asn Gly Leu Phe Ser Lys Lys Glu 
        515                 520                 525             


Ile Glu Glu Ile Arg Asn Thr Thr Leu Gln Asp Val Leu Val Ala Val 
    530                 535                 540                 


Ile Asn Ile Asp Pro Ser Ala Leu Gln Pro Asn Val Phe Val Trp His 
545                 550                 555                 560 


Lys Gly Asp Pro Cys Pro Gln Pro Arg Gln Leu Ser Thr Glu Gly Leu 
                565                 570                 575     


Pro Ala Cys Ala Pro Ser Val Val Arg Asp Tyr Phe Glu Gly Ser Gly 
            580                 585                 590         


Phe Gly Phe Gly Val Thr Ile Gly Thr Leu Cys Cys Phe Pro Leu Val 
        595                 600                 605             


Ser Leu Leu Ser Ala Trp Ile Val Ala Arg Leu Arg Met Arg Asn Phe 
    610                 615                 620                 


Lys Arg Leu Gln Gly Gln Asp Arg Gln Ser Ile Val Ser Glu Lys Leu 
625                 630                 635                 640 


Val Gly Gly Met Glu Ala Leu Glu Trp Gln Gly His Lys Glu Pro Cys 
                645                 650                 655     


Arg Pro Val Leu Val Tyr Leu Gln Pro Gly Gln Ile Arg Val Val Asp 
            660                 665                 670         


Gly Arg Leu Thr Val Leu Arg Thr Ile Gln Leu Gln Pro Pro Gln Lys 
        675                 680                 685             


Val Asn Phe Val Leu Ser Ser Asn Arg Gly Arg Arg Thr Leu Leu Leu 
    690                 695                 700                 


Lys Ile Pro Lys Glu Tyr Asp Leu Val Leu Leu Phe Asn Leu Glu Glu 
705                 710                 715                 720 


Glu Arg Gln Ala Leu Val Glu Asn Leu Arg Gly Ala Leu Lys Glu Ser 
                725                 730                 735     


Gly Leu Ser Ile Gln Glu Trp Glu Leu Arg Glu Gln Glu Leu Met Arg 
            740                 745                 750         


Ala Ala Val Thr Arg Glu Gln Arg Arg His Leu Leu Glu Thr Phe Phe 
        755                 760                 765             


Arg His Leu Phe Ser Gln Val Leu Asp Ile Asn Gln Ala Asp Ala Gly 
    770                 775                 780                 


Thr Leu Pro Leu Asp Ser Ser Gln Lys Val Arg Glu Ala Leu Thr Cys 
785                 790                 795                 800 


Glu Leu Ser Arg Ala Glu Phe Ala Glu Ser Leu Gly Leu Lys Pro Gln 
                805                 810                 815     


Asp Met Phe Val Glu Ser Met Phe Ser Leu Ala Asp Lys Asp Gly Asn 
            820                 825                 830         


Gly Tyr Leu Ser Phe Arg Glu Phe Leu Asp Ile Leu Val Val Phe Met 
        835                 840                 845             


Lys Gly Ser Pro Glu Glu Lys Ser Arg Leu Met Phe Arg Met Tyr Asp 
    850                 855                 860                 


Phe Asp Gly Asn Gly Leu Ile Ser Lys Asp Glu Phe Ile Arg Met Leu 
865                 870                 875                 880 


Arg Ser Phe Ile Glu Ile Ser Asn Asn Cys Leu Ser Lys Ala Gln Leu 
                885                 890                 895     


Ala Glu Val Val Glu Ser Met Phe Arg Glu Ser Gly Phe Gln Asp Lys 
            900                 905                 910         


Glu Glu Leu Thr Trp Glu Asp Phe His Phe Met Leu Arg Asp His Asn 
        915                 920                 925             


Ser Glu Leu Arg Phe Thr Gln Leu Cys Val Lys Gly Val Glu Val Pro 
    930                 935                 940                 


Glu Val Ile Lys Asp Leu Cys Arg Arg Ala Ser Tyr Ile Ser Gln Asp 
945                 950                 955                 960 


Met Ile Cys Pro Ser Pro Arg Val Ser Ala Arg Cys Ser Arg Ser Asp 
                965                 970                 975     


Ile Glu Thr Glu Leu Thr Pro Gln Arg Leu Gln Cys Pro Met Asp Thr 
            980                 985                 990         


Asp Pro Pro Gln Glu Ile Arg Arg  Arg Phe Gly Lys Lys  Val Thr Ser 
        995                 1000                 1005             


Phe Gln  Pro Leu Leu Phe Thr  Glu Ala His Arg Glu  Lys Phe Gln 
    1010                 1015                 1020             


Arg Ser  Cys Leu His Gln Thr  Val Gln Gln Phe Lys  Arg Phe Ile 
    1025                 1030                 1035             


Glu Asn  Tyr Arg Arg His Ile  Gly Cys Val Ala Val  Phe Tyr Ala 
    1040                 1045                 1050             


Ile Ala  Gly Gly Leu Phe Leu  Glu Arg Ala Tyr Tyr  Tyr Ala Phe 
    1055                 1060                 1065             


Ala Ala  His His Thr Gly Ile  Thr Asp Thr Thr Arg  Val Gly Ile 
    1070                 1075                 1080             


Ile Leu  Ser Arg Gly Thr Ala  Ala Ser Ile Ser Phe  Met Phe Ser 
    1085                 1090                 1095             


Tyr Ile  Leu Leu Thr Met Cys  Arg Asn Leu Ile Thr  Phe Leu Arg 
    1100                 1105                 1110             


Glu Thr  Phe Leu Asn Arg Tyr  Val Pro Phe Asp Ala  Ala Val Asp 
    1115                 1120                 1125             


Phe His  Arg Leu Ile Ala Ser  Thr Ala Ile Val Leu  Thr Val Leu 
    1130                 1135                 1140             


His Ser  Val Gly His Val Val  Asn Val Tyr Leu Phe  Ser Ile Ser 
    1145                 1150                 1155             


Pro Leu  Ser Val Leu Ser Cys  Leu Phe Pro Gly Leu  Phe His Asp 
    1160                 1165                 1170             


Asp Gly  Ser Glu Leu Pro Gln  Lys Tyr Tyr Trp Trp  Phe Phe Gln 
    1175                 1180                 1185             


Thr Val  Pro Gly Leu Thr Gly  Val Val Leu Leu Leu  Ile Leu Ala 
    1190                 1195                 1200             


Ile Met  Tyr Val Phe Ala Ser  His His Phe Arg Arg  Arg Ser Phe 
    1205                 1210                 1215             


Arg Gly  Phe Trp Leu Thr His  His Leu Tyr Ile Leu  Leu Tyr Val 
    1220                 1225                 1230             


Leu Leu  Ile Ile His Gly Ser  Phe Ala Leu Ile Gln  Leu Pro Arg 
    1235                 1240                 1245             


Phe His  Ile Phe Phe Leu Val  Pro Ala Ile Ile Tyr  Gly Gly Asp 
    1250                 1255                 1260             


Lys Leu  Val Ser Leu Ser Arg  Lys Lys Val Glu Ile  Ser Val Val 
    1265                 1270                 1275             


Lys Ala  Glu Leu Leu Pro Ser  Gly Val Thr His Leu  Arg Phe Gln 
    1280                 1285                 1290             


Arg Pro  Gln Gly Phe Glu Tyr  Lys Ser Gly Gln Trp  Val Arg Ile 
    1295                 1300                 1305             


Ala Cys  Leu Ala Leu Gly Thr  Thr Glu Tyr His Pro  Phe Thr Leu 
    1310                 1315                 1320             


Thr Ser  Ala Pro His Glu Asp  Thr Leu Ser Leu His  Ile Arg Ala 
    1325                 1330                 1335             


Ala Gly  Pro Trp Thr Thr Arg  Leu Arg Glu Ile Tyr  Ser Ala Pro 
    1340                 1345                 1350             


Thr Gly  Asp Arg Cys Ala Arg  Tyr Pro Lys Leu Tyr  Leu Asp Gly 
    1355                 1360                 1365             


Pro Phe  Gly Glu Gly His Gln  Glu Trp His Lys Phe  Glu Val Ser 
    1370                 1375                 1380             


Val Leu  Val Gly Gly Gly Ile  Gly Val Thr Pro Phe  Ala Ser Ile 
    1385                 1390                 1395             


Leu Lys  Asp Leu Val Phe Lys  Ser Ser Val Ser Cys  Gln Val Phe 
    1400                 1405                 1410             


Cys Lys  Lys Ile Tyr Phe Ile  Trp Val Thr Arg Thr  Gln Arg Gln 
    1415                 1420                 1425             


Phe Glu  Trp Leu Ala Asp Ile  Ile Arg Glu Val Glu  Glu Asn Asp 
    1430                 1435                 1440             


His Gln  Asp Leu Val Ser Val  His Ile Tyr Ile Thr  Gln Leu Ala 
    1445                 1450                 1455             


Glu Lys  Phe Asp Leu Arg Thr  Thr Met Leu Tyr Ile  Cys Glu Arg 
    1460                 1465                 1470             


His Phe  Gln Lys Val Leu Asn  Arg Ser Leu Phe Thr  Gly Leu Arg 
    1475                 1480                 1485             


Ser Ile  Thr His Phe Gly Arg  Pro Pro Phe Glu Pro  Phe Phe Asn 
    1490                 1495                 1500             


Ser Leu  Gln Glu Val His Pro  Gln Val Arg Lys Ile  Gly Val Phe 
    1505                 1510                 1515             


Ser Cys  Gly Pro Pro Gly Met  Thr Lys Asn Val Glu  Lys Ala Cys 
    1520                 1525                 1530             


Gln Leu  Ile Asn Arg Gln Asp  Arg Thr His Phe Ser  His His Tyr 
    1535                 1540                 1545             


Glu Asn  Phe 
    1550     


<210>  4290
<211>  712
<212>  PRT
<213>  Homo sapiens

<400>  4290

Met Asp Thr Ser Ser Lys Glu Asn Ile Gln Leu Phe Cys Lys Thr Ser 
1               5                   10                  15      


Val Gln Pro Val Gly Arg Pro Ser Phe Lys Thr Glu Tyr Pro Ser Ser 
            20                  25                  30          


Glu Glu Lys Gln Pro Cys Cys Gly Glu Leu Lys Val Phe Leu Cys Ala 
        35                  40                  45              


Leu Ser Phe Val Tyr Phe Ala Lys Ala Leu Ala Glu Gly Tyr Leu Lys 
    50                  55                  60                  


Ser Thr Ile Thr Gln Ile Glu Arg Arg Phe Asp Ile Pro Ser Ser Leu 
65                  70                  75                  80  


Val Gly Val Ile Asp Gly Ser Phe Glu Ile Gly Asn Leu Leu Val Ile 
                85                  90                  95      


Thr Phe Val Ser Tyr Phe Gly Ala Lys Leu His Arg Pro Lys Ile Ile 
            100                 105                 110         


Gly Ala Gly Cys Val Ile Met Gly Val Gly Thr Leu Leu Ile Ala Met 
        115                 120                 125             


Pro Gln Phe Phe Met Glu Gln Tyr Lys Tyr Glu Arg Tyr Ser Pro Ser 
    130                 135                 140                 


Ser Asn Ser Thr Leu Ser Ile Ser Pro Cys Leu Leu Glu Ser Ser Ser 
145                 150                 155                 160 


Gln Leu Pro Val Ser Val Met Glu Lys Ser Lys Ser Lys Ile Ser Asn 
                165                 170                 175     


Glu Cys Glu Val Asp Thr Ser Ser Ser Met Trp Ile Tyr Val Phe Leu 
            180                 185                 190         


Gly Asn Leu Leu Arg Gly Ile Gly Glu Thr Pro Ile Gln Pro Leu Gly 
        195                 200                 205             


Ile Ala Tyr Leu Asp Asp Phe Ala Ser Glu Asp Asn Ala Ala Phe Tyr 
    210                 215                 220                 


Ile Gly Cys Val Gln Thr Val Ala Ile Ile Gly Pro Ile Phe Gly Phe 
225                 230                 235                 240 


Leu Leu Gly Ser Leu Cys Ala Lys Leu Tyr Val Asp Ile Gly Phe Val 
                245                 250                 255     


Asn Leu Asp His Ile Thr Ile Thr Pro Lys Asp Pro Gln Trp Val Gly 
            260                 265                 270         


Ala Trp Trp Leu Gly Tyr Leu Ile Ala Gly Ile Ile Ser Leu Leu Ala 
        275                 280                 285             


Ala Val Pro Phe Trp Tyr Leu Pro Lys Ser Leu Pro Arg Ser Gln Ser 
    290                 295                 300                 


Arg Glu Asp Ser Asn Ser Ser Ser Glu Lys Ser Lys Phe Ile Ile Asp 
305                 310                 315                 320 


Asp His Thr Asp Tyr Gln Thr Pro Gln Gly Glu Asn Ala Lys Ile Met 
                325                 330                 335     


Glu Met Ala Arg Asp Phe Leu Pro Ser Leu Lys Asn Leu Phe Gly Asn 
            340                 345                 350         


Pro Val Tyr Phe Leu Tyr Leu Cys Thr Ser Thr Val Gln Phe Asn Ser 
        355                 360                 365             


Leu Phe Gly Met Val Thr Tyr Lys Pro Lys Tyr Ile Glu Gln Gln Tyr 
    370                 375                 380                 


Gly Gln Ser Ser Ser Arg Ala Asn Phe Val Ile Gly Leu Ile Asn Ile 
385                 390                 395                 400 


Pro Ala Val Ala Leu Gly Ile Phe Ser Gly Gly Ile Val Met Lys Lys 
                405                 410                 415     


Phe Arg Ile Ser Val Cys Gly Ala Ala Lys Leu Tyr Leu Gly Ser Ser 
            420                 425                 430         


Val Phe Gly Tyr Leu Leu Phe Leu Ser Leu Phe Ala Leu Gly Cys Glu 
        435                 440                 445             


Asn Ser Asp Val Ala Gly Leu Thr Val Ser Tyr Gln Gly Thr Lys Pro 
    450                 455                 460                 


Val Ser Tyr His Glu Arg Ala Leu Phe Ser Asp Cys Asn Ser Arg Cys 
465                 470                 475                 480 


Lys Cys Ser Glu Thr Lys Trp Glu Pro Met Cys Gly Glu Asn Gly Ile 
                485                 490                 495     


Thr Tyr Val Ser Ala Cys Leu Ala Gly Cys Gln Thr Ser Asn Arg Ser 
            500                 505                 510         


Gly Lys Asn Ile Ile Phe Tyr Asn Cys Thr Cys Val Gly Ile Ala Ala 
        515                 520                 525             


Ser Lys Ser Gly Asn Ser Ser Gly Ile Val Gly Arg Cys Gln Lys Asp 
    530                 535                 540                 


Asn Gly Cys Pro Gln Met Phe Leu Tyr Phe Leu Val Ile Ser Val Ile 
545                 550                 555                 560 


Thr Ser Tyr Thr Leu Ser Leu Gly Gly Ile Pro Gly Tyr Ile Leu Leu 
                565                 570                 575     


Leu Arg Cys Ile Lys Pro Gln Leu Lys Ser Phe Ala Leu Gly Ile Tyr 
            580                 585                 590         


Thr Leu Ala Ile Arg Val Leu Ala Gly Ile Pro Ala Pro Val Tyr Phe 
        595                 600                 605             


Gly Val Leu Ile Asp Thr Ser Cys Leu Lys Trp Gly Phe Lys Arg Cys 
    610                 615                 620                 


Gly Ser Arg Gly Ser Cys Arg Leu Tyr Asp Ser Asn Val Phe Arg His 
625                 630                 635                 640 


Ile Tyr Leu Gly Leu Thr Val Ile Leu Gly Thr Val Ser Ile Leu Leu 
                645                 650                 655     


Ser Ile Ala Val Leu Phe Ile Leu Lys Lys Asn Tyr Val Ser Lys His 
            660                 665                 670         


Arg Ser Phe Ile Thr Lys Arg Glu Arg Thr Met Val Ser Thr Arg Phe 
        675                 680                 685             


Gln Lys Glu Asn Tyr Thr Thr Ser Asp His Leu Leu Gln Pro Asn Tyr 
    690                 695                 700                 


Trp Pro Gly Lys Glu Thr Gln Leu 
705                 710         


<210>  4291
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  4291

Met Ser Lys Pro Pro Asp Leu Leu Leu Arg Leu Leu Arg Gly Ala Pro 
1               5                   10                  15      


Arg Gln Arg Val Cys Thr Leu Phe Ile Ile Gly Phe Lys Phe Thr Phe 
            20                  25                  30          


Phe Val Ser Ile Met Ile Tyr Trp His Val Val Gly Glu Pro Lys Glu 
        35                  40                  45              


Lys Gly Gln Leu Tyr Asn Leu Pro Ala Glu Ile Pro Cys Pro Thr Leu 
    50                  55                  60                  


Thr Pro Pro Thr Pro Pro Ser His Gly Pro Thr Pro Gly Asn Ile Phe 
65                  70                  75                  80  


Phe Leu Glu Thr Ser Asp Arg Thr Asn Pro Asn Phe Leu Phe Met Cys 
                85                  90                  95      


Ser Val Glu Ser Ala Ala Arg Thr His Pro Glu Ser His Val Leu Val 
            100                 105                 110         


Leu Met Lys Gly Leu Pro Gly Gly Asn Ala Ser Leu Pro Arg His Leu 
        115                 120                 125             


Gly Ile Ser Leu Leu Ser Cys Phe Pro Asn Val Gln Met Leu Pro Leu 
    130                 135                 140                 


Asp Leu Arg Glu Leu Phe Arg Asp Thr Pro Leu Ala Asp Trp Tyr Ala 
145                 150                 155                 160 


Ala Val Gln Gly Arg Trp Glu Pro Tyr Leu Leu Pro Val Leu Ser Asp 
                165                 170                 175     


Ala Ser Arg Ile Ala Leu Met Trp Lys Phe Gly Gly Ile Tyr Leu Asp 
            180                 185                 190         


Thr Asp Phe Ile Val Leu Lys Asn Leu Arg Asn Leu Thr Asn Val Leu 
        195                 200                 205             


Gly Thr Gln Ser Arg Tyr Val Leu Asn Gly Ala Phe Leu Ala Phe Glu 
    210                 215                 220                 


Arg Arg His Glu Phe Met Ala Leu Cys Met Arg Asp Phe Val Asp His 
225                 230                 235                 240 


Tyr Asn Gly Trp Ile Trp Gly His Gln Gly Pro Gln Leu Leu Thr Arg 
                245                 250                 255     


Val Phe Lys Lys Trp Cys Ser Ile Arg Ser Leu Ala Glu Ser Arg Ala 
            260                 265                 270         


Cys Arg Gly Val Thr Thr Leu Pro Pro Glu Ala Phe Tyr Pro Ile Pro 
        275                 280                 285             


Trp Gln Asp Trp Lys Lys Tyr Phe Glu Asp Ile Asn Pro Glu Glu Leu 
    290                 295                 300                 


Pro Arg Leu Leu Ser Ala Thr Tyr Ala Val His Val Trp Asn Lys Lys 
305                 310                 315                 320 


Ser Gln Gly Thr Arg Phe Glu Ala Thr Ser Arg Ala Leu Leu Ala Gln 
                325                 330                 335     


Leu His Ala Arg Tyr Cys Pro Thr Thr His Glu Ala Met Lys Met Tyr 
            340                 345                 350         


Leu 
    


<210>  4292
<211>  714
<212>  PRT
<213>  Homo sapiens

<400>  4292

Met Pro Val Arg Phe Lys Gly Leu Ser Glu Tyr Gln Arg Asn Phe Leu 
1               5                   10                  15      


Trp Lys Lys Ser Tyr Leu Ser Glu Ser Cys Asn Ser Ser Val Gly Arg 
            20                  25                  30          


Lys Tyr Pro Trp Ala Gly Leu Arg Ser Asp Gln Leu Gly Ile Thr Lys 
        35                  40                  45              


Glu Pro Ser Phe Ile Ser Lys Arg Arg Val Pro Tyr His Asp Pro Gln 
    50                  55                  60                  


Ile Ser Lys Ser Leu Glu Trp Asn Gly Ala Ile Ser Glu Ser Asn Val 
65                  70                  75                  80  


Val Ala Ser Pro Glu Pro Glu Ala Pro Glu Thr Pro Lys Ser Gln Glu 
                85                  90                  95      


Ala Glu Gln Lys Asp Val Thr Gln Glu Arg Val His Ser Leu Glu Ala 
            100                 105                 110         


Ser Arg Val Pro Lys Arg Thr Arg Ser His Ser Ala Asp Ser Arg Ala 
        115                 120                 125             


Glu Gly Ala Ser Asp Val Glu Asn Asn Glu Gly Val Thr Asn His Thr 
    130                 135                 140                 


Pro Val Asn Glu Asn Val Glu Leu Glu His Ser Thr Lys Val Leu Ser 
145                 150                 155                 160 


Glu Asn Val Asp Asn Gly Leu Asp Arg Leu Leu Arg Lys Lys Ala Gly 
                165                 170                 175     


Leu Thr Val Val Pro Ser Tyr Asn Ala Leu Arg Asn Ser Glu Tyr Gln 
            180                 185                 190         


Arg Gln Phe Val Trp Lys Thr Ser Lys Glu Thr Ala Pro Ala Phe Ala 
        195                 200                 205             


Ala Asn Gln Val Phe His Asn Lys Ser Gln Phe Val Pro Pro Phe Lys 
    210                 215                 220                 


Gly Asn Ser Val Ile His Glu Thr Glu Tyr Lys Arg Asn Phe Lys Gly 
225                 230                 235                 240 


Leu Ser Pro Val Lys Glu Pro Lys Leu Arg Asn Asp Leu Arg Glu Asn 
                245                 250                 255     


Arg Asn Leu Glu Thr Val Ser Pro Glu Arg Lys Ser Asn Lys Ile Asp 
            260                 265                 270         


Asp Arg Leu Lys Leu Glu Ala Glu Met Glu Leu Lys Asp Leu His Gln 
        275                 280                 285             


Pro Lys Arg Lys Leu Thr Pro Trp Lys His Gln Arg Leu Gly Lys Val 
    290                 295                 300                 


Asn Ser Glu Tyr Arg Ala Lys Phe Leu Ser Pro Ala Gln Tyr Leu Tyr 
305                 310                 315                 320 


Lys Ala Gly Ala Trp Thr His Val Lys Gly Asn Met Pro Asn Gln Val 
                325                 330                 335     


Lys Glu Leu Arg Glu Lys Ala Glu Phe Tyr Arg Lys Arg Val Gln Gly 
            340                 345                 350         


Thr His Phe Ser Arg Asp His Leu Asn Gln Ile Leu Ser Asp Ser Asn 
        355                 360                 365             


Cys Cys Trp Asp Val Ser Ser Thr Thr Ser Ser Glu Gly Thr Val Ser 
    370                 375                 380                 


Ser Asn Ile Arg Ala Leu Asp Leu Ala Gly Asp Pro Thr Ser His Lys 
385                 390                 395                 400 


Thr Leu Gln Lys Cys Pro Ser Thr Glu Pro Glu Glu Lys Gly Asn Ile 
                405                 410                 415     


Val Glu Glu Gln Pro Gln Lys Asn Thr Thr Glu Lys Leu Gly Val Ser 
            420                 425                 430         


Ala Pro Thr Ile Pro Val Arg Arg Arg Leu Ala Trp Asp Thr Glu Asn 
        435                 440                 445             


Thr Ser Glu Asp Val Gln Lys Gln Pro Gly Glu Lys Glu Glu Glu Asp 
    450                 455                 460                 


Asp Asn Glu Glu Glu Gly Asp Arg Lys Thr Gly Lys Gln Ala Phe Met 
465                 470                 475                 480 


Gly Glu Gln Glu Lys Leu Asp Val Arg Glu Lys Ser Lys Ala Asp Lys 
                485                 490                 495     


Met Lys Glu Gly Ser Asp Ser Ser Val Ser Ser Glu Lys Gly Gly Arg 
            500                 505                 510         


Leu Pro Thr Pro Lys Leu Arg Glu Leu Gly Gly Ile Gln Arg Thr His 
        515                 520                 525             


His Asp Leu Thr Thr Pro Ala Val Gly Gly Ala Val Leu Val Ser Pro 
    530                 535                 540                 


Ser Lys Met Lys Pro Pro Ala Pro Glu Gln Arg Lys Arg Met Thr Ser 
545                 550                 555                 560 


Gln Asp Cys Leu Glu Thr Ser Lys Asn Asp Phe Thr Lys Lys Glu Ser 
                565                 570                 575     


Arg Ala Val Ser Leu Leu Thr Ser Pro Ala Ala Gly Ile Lys Thr Val 
            580                 585                 590         


Asp Pro Leu Pro Leu Arg Glu Asp Ser Glu Asp Asn Ile His Lys Phe 
        595                 600                 605             


Ala Glu Ala Thr Leu Pro Val Ser Lys Ile Pro Lys Tyr Pro Thr Asn 
    610                 615                 620                 


Pro Pro Gly Gln Leu Pro Ser Pro Pro His Val Pro Ser Tyr Trp His 
625                 630                 635                 640 


Pro Ser Arg Arg Ile Gln Gly Ser Leu Arg Asp Pro Glu Phe Gln His 
                645                 650                 655     


Asn Val Gly Lys Ala Arg Met Asn Asn Leu Gln Leu Pro Gln His Glu 
            660                 665                 670         


Ala Phe Asn Asp Glu Asp Glu Asp Arg Leu Ser Glu Ile Ser Ala Arg 
        675                 680                 685             


Ser Ala Ala Ser Ser Leu Arg Ala Phe Gln Thr Leu Ala Arg Ala Lys 
    690                 695                 700                 


Lys Arg Lys Glu Asn Phe Trp Gly Lys Thr 
705                 710                 


<210>  4293
<211>  1032
<212>  PRT
<213>  Homo sapiens

<400>  4293

Met Gly Phe Cys Arg Ser Ala Leu His Pro Leu Ser Leu Leu Val Gln 
1               5                   10                  15      


Ala Ile Met Leu Ala Met Thr Leu Ala Leu Gly Thr Leu Pro Ala Phe 
            20                  25                  30          


Leu Pro Cys Glu Leu Gln Pro His Gly Leu Val Asn Cys Asn Trp Leu 
        35                  40                  45              


Phe Leu Lys Ser Val Pro His Phe Ser Met Ala Ala Pro Arg Gly Asn 
    50                  55                  60                  


Val Thr Ser Leu Ser Leu Ser Ser Asn Arg Ile His His Leu His Asp 
65                  70                  75                  80  


Ser Asp Phe Ala His Leu Pro Ser Leu Arg His Leu Asn Leu Lys Trp 
                85                  90                  95      


Asn Cys Pro Pro Val Gly Leu Ser Pro Met His Phe Pro Cys His Met 
            100                 105                 110         


Thr Ile Glu Pro Ser Thr Phe Leu Ala Val Pro Thr Leu Glu Glu Leu 
        115                 120                 125             


Asn Leu Ser Tyr Asn Asn Ile Met Thr Val Pro Ala Leu Pro Lys Ser 
    130                 135                 140                 


Leu Ile Ser Leu Ser Leu Ser His Thr Asn Ile Leu Met Leu Asp Ser 
145                 150                 155                 160 


Ala Ser Leu Ala Gly Leu His Ala Leu Arg Phe Leu Phe Met Asp Gly 
                165                 170                 175     


Asn Cys Tyr Tyr Lys Asn Pro Cys Arg Gln Ala Leu Glu Val Ala Pro 
            180                 185                 190         


Gly Ala Leu Leu Gly Leu Gly Asn Leu Thr His Leu Ser Leu Lys Tyr 
        195                 200                 205             


Asn Asn Leu Thr Val Val Pro Arg Asn Leu Pro Ser Ser Leu Glu Tyr 
    210                 215                 220                 


Leu Leu Leu Ser Tyr Asn Arg Ile Val Lys Leu Ala Pro Glu Asp Leu 
225                 230                 235                 240 


Ala Asn Leu Thr Ala Leu Arg Val Leu Asp Val Gly Gly Asn Cys Arg 
                245                 250                 255     


Arg Cys Asp His Ala Pro Asn Pro Cys Met Glu Cys Pro Arg His Phe 
            260                 265                 270         


Pro Gln Leu His Pro Asp Thr Phe Ser His Leu Ser Arg Leu Glu Gly 
        275                 280                 285             


Leu Val Leu Lys Asp Ser Ser Leu Ser Trp Leu Asn Ala Ser Trp Phe 
    290                 295                 300                 


Arg Gly Leu Gly Asn Leu Arg Val Leu Asp Leu Ser Glu Asn Phe Leu 
305                 310                 315                 320 


Tyr Lys Cys Ile Thr Lys Thr Lys Ala Phe Gln Gly Leu Thr Gln Leu 
                325                 330                 335     


Arg Lys Leu Asn Leu Ser Phe Asn Tyr Gln Lys Arg Val Ser Phe Ala 
            340                 345                 350         


His Leu Ser Leu Ala Pro Ser Phe Gly Ser Leu Val Ala Leu Lys Glu 
        355                 360                 365             


Leu Asp Met His Gly Ile Phe Phe Arg Ser Leu Asp Glu Thr Thr Leu 
    370                 375                 380                 


Arg Pro Leu Ala Arg Leu Pro Met Leu Gln Thr Leu Arg Leu Gln Met 
385                 390                 395                 400 


Asn Phe Ile Asn Gln Ala Gln Leu Gly Ile Phe Arg Ala Phe Pro Gly 
                405                 410                 415     


Leu Arg Tyr Val Asp Leu Ser Asp Asn Arg Ile Ser Gly Ala Ser Glu 
            420                 425                 430         


Leu Thr Ala Thr Met Gly Glu Ala Asp Gly Gly Glu Lys Val Trp Leu 
        435                 440                 445             


Gln Pro Gly Asp Leu Ala Pro Ala Pro Val Asp Thr Pro Ser Ser Glu 
    450                 455                 460                 


Asp Phe Arg Pro Asn Cys Ser Thr Leu Asn Phe Thr Leu Asp Leu Ser 
465                 470                 475                 480 


Arg Asn Asn Leu Val Thr Val Gln Pro Glu Met Phe Ala Gln Leu Ser 
                485                 490                 495     


His Leu Gln Cys Leu Arg Leu Ser His Asn Cys Ile Ser Gln Ala Val 
            500                 505                 510         


Asn Gly Ser Gln Phe Leu Pro Leu Thr Gly Leu Gln Val Leu Asp Leu 
        515                 520                 525             


Ser His Asn Lys Leu Asp Leu Tyr His Glu His Ser Phe Thr Glu Leu 
    530                 535                 540                 


Pro Arg Leu Glu Ala Leu Asp Leu Ser Tyr Asn Ser Gln Pro Phe Gly 
545                 550                 555                 560 


Met Gln Gly Val Gly His Asn Phe Ser Phe Val Ala His Leu Arg Thr 
                565                 570                 575     


Leu Arg His Leu Ser Leu Ala His Asn Asn Ile His Ser Gln Val Ser 
            580                 585                 590         


Gln Gln Leu Cys Ser Thr Ser Leu Arg Ala Leu Asp Phe Ser Gly Asn 
        595                 600                 605             


Ala Leu Gly His Met Trp Ala Glu Gly Asp Leu Tyr Leu His Phe Phe 
    610                 615                 620                 


Gln Gly Leu Ser Gly Leu Ile Trp Leu Asp Leu Ser Gln Asn Arg Leu 
625                 630                 635                 640 


His Thr Leu Leu Pro Gln Thr Leu Arg Asn Leu Pro Lys Ser Leu Gln 
                645                 650                 655     


Val Leu Arg Leu Arg Asp Asn Tyr Leu Ala Phe Phe Lys Trp Trp Ser 
            660                 665                 670         


Leu His Phe Leu Pro Lys Leu Glu Val Leu Asp Leu Ala Gly Asn Gln 
        675                 680                 685             


Leu Lys Ala Leu Thr Asn Gly Ser Leu Pro Ala Gly Thr Arg Leu Arg 
    690                 695                 700                 


Arg Leu Asp Val Ser Cys Asn Ser Ile Ser Phe Val Ala Pro Gly Phe 
705                 710                 715                 720 


Phe Ser Lys Ala Lys Glu Leu Arg Glu Leu Asn Leu Ser Ala Asn Ala 
                725                 730                 735     


Leu Lys Thr Val Asp His Ser Trp Phe Gly Pro Leu Ala Ser Ala Leu 
            740                 745                 750         


Gln Ile Leu Asp Val Ser Ala Asn Pro Leu His Cys Ala Cys Gly Ala 
        755                 760                 765             


Ala Phe Met Asp Phe Leu Leu Glu Val Gln Ala Ala Val Pro Gly Leu 
    770                 775                 780                 


Pro Ser Arg Val Lys Cys Gly Ser Pro Gly Gln Leu Gln Gly Leu Ser 
785                 790                 795                 800 


Ile Phe Ala Gln Asp Leu Arg Leu Cys Leu Asp Glu Ala Leu Ser Trp 
                805                 810                 815     


Asp Cys Phe Ala Leu Ser Leu Leu Ala Val Ala Leu Gly Leu Gly Val 
            820                 825                 830         


Pro Met Leu His His Leu Cys Gly Trp Asp Leu Trp Tyr Cys Phe His 
        835                 840                 845             


Leu Cys Leu Ala Trp Leu Pro Trp Arg Gly Arg Gln Ser Gly Arg Asp 
    850                 855                 860                 


Glu Asp Ala Leu Pro Tyr Asp Ala Phe Val Val Phe Asp Lys Thr Gln 
865                 870                 875                 880 


Ser Ala Val Ala Asp Trp Val Tyr Asn Glu Leu Arg Gly Gln Leu Glu 
                885                 890                 895     


Glu Cys Arg Gly Arg Trp Ala Leu Arg Leu Cys Leu Glu Glu Arg Asp 
            900                 905                 910         


Trp Leu Pro Gly Lys Thr Leu Phe Glu Asn Leu Trp Ala Ser Val Tyr 
        915                 920                 925             


Gly Ser Arg Lys Thr Leu Phe Val Leu Ala His Thr Asp Arg Val Ser 
    930                 935                 940                 


Gly Leu Leu Arg Ala Ser Phe Leu Leu Ala Gln Gln Arg Leu Leu Glu 
945                 950                 955                 960 


Asp Arg Lys Asp Val Val Val Leu Val Ile Leu Ser Pro Asp Gly Arg 
                965                 970                 975     


Arg Ser Arg Tyr Val Arg Leu Arg Gln Arg Leu Cys Arg Gln Ser Val 
            980                 985                 990         


Leu Leu Trp Pro His Gln Pro Ser  Gly Gln Arg Ser Phe  Trp Ala Gln 
        995                 1000                 1005             


Leu Gly  Met Ala Leu Thr Arg  Asp Asn His His Phe  Tyr Asn Arg 
    1010                 1015                 1020             


Asn Phe  Cys Gln Gly Pro Thr  Ala Glu 
    1025                 1030         


<210>  4294
<211>  986
<212>  PRT
<213>  Homo sapiens

<400>  4294

Met Ala Leu Arg Arg Leu Gly Ala Ala Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Ala Ala Val Glu Glu Thr Leu Met Asp Ser Thr Thr Ala Thr Ala Glu 
            20                  25                  30          


Leu Gly Trp Met Val His Pro Pro Ser Gly Trp Glu Glu Val Ser Gly 
        35                  40                  45              


Tyr Asp Glu Asn Met Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val 
    50                  55                  60                  


Phe Glu Ser Ser Gln Asn Asn Trp Leu Arg Thr Lys Phe Ile Arg Arg 
65                  70                  75                  80  


Arg Gly Ala His Arg Ile His Val Glu Met Lys Phe Ser Val Arg Asp 
                85                  90                  95      


Cys Ser Ser Ile Pro Ser Val Pro Gly Ser Cys Lys Glu Thr Phe Asn 
            100                 105                 110         


Leu Tyr Tyr Tyr Glu Ala Asp Phe Asp Ser Ala Thr Lys Thr Phe Pro 
        115                 120                 125             


Asn Trp Met Glu Asn Pro Trp Val Lys Val Asp Thr Ile Ala Ala Asp 
    130                 135                 140                 


Glu Ser Phe Ser Gln Val Asp Leu Gly Gly Arg Val Met Lys Ile Asn 
145                 150                 155                 160 


Thr Glu Val Arg Ser Phe Gly Pro Val Ser Arg Ser Gly Phe Tyr Leu 
                165                 170                 175     


Ala Phe Gln Asp Tyr Gly Gly Cys Met Ser Leu Ile Ala Val Arg Val 
            180                 185                 190         


Phe Tyr Arg Lys Cys Pro Arg Ile Ile Gln Asn Gly Ala Ile Phe Gln 
        195                 200                 205             


Glu Thr Leu Ser Gly Ala Glu Ser Thr Ser Leu Val Ala Ala Arg Gly 
    210                 215                 220                 


Ser Cys Ile Ala Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr 
225                 230                 235                 240 


Cys Asn Gly Asp Gly Glu Trp Leu Val Pro Ile Gly Arg Cys Met Cys 
                245                 250                 255     


Lys Ala Gly Phe Glu Ala Val Glu Asn Gly Thr Val Cys Arg Gly Cys 
            260                 265                 270         


Pro Ser Gly Thr Phe Lys Ala Asn Gln Gly Asp Glu Ala Cys Thr His 
        275                 280                 285             


Cys Pro Ile Asn Ser Arg Thr Thr Ser Glu Gly Ala Thr Asn Cys Val 
    290                 295                 300                 


Cys Arg Asn Gly Tyr Tyr Arg Ala Asp Leu Asp Pro Leu Asp Met Pro 
305                 310                 315                 320 


Cys Thr Thr Ile Pro Ser Ala Pro Gln Ala Val Ile Ser Ser Val Asn 
                325                 330                 335     


Glu Thr Ser Leu Met Leu Glu Trp Thr Pro Pro Arg Asp Ser Gly Gly 
            340                 345                 350         


Arg Glu Asp Leu Val Tyr Asn Ile Ile Cys Lys Ser Cys Gly Ser Gly 
        355                 360                 365             


Arg Gly Ala Cys Thr Arg Cys Gly Asp Asn Val Gln Tyr Ala Pro Arg 
    370                 375                 380                 


Gln Leu Gly Leu Thr Glu Pro Arg Ile Tyr Ile Ser Asp Leu Leu Ala 
385                 390                 395                 400 


His Thr Gln Tyr Thr Phe Glu Ile Gln Ala Val Asn Gly Val Thr Asp 
                405                 410                 415     


Gln Ser Pro Phe Ser Pro Gln Phe Ala Ser Val Asn Ile Thr Thr Asn 
            420                 425                 430         


Gln Ala Ala Pro Ser Ala Val Ser Ile Met His Gln Val Ser Arg Thr 
        435                 440                 445             


Val Asp Ser Ile Thr Leu Ser Trp Ser Gln Pro Asp Gln Pro Asn Gly 
    450                 455                 460                 


Val Ile Leu Asp Tyr Glu Leu Gln Tyr Tyr Glu Lys Glu Leu Ser Glu 
465                 470                 475                 480 


Tyr Asn Ala Thr Ala Ile Lys Ser Pro Thr Asn Thr Val Thr Val Gln 
                485                 490                 495     


Gly Leu Lys Ala Gly Ala Ile Tyr Val Phe Gln Val Arg Ala Arg Thr 
            500                 505                 510         


Val Ala Gly Tyr Gly Arg Tyr Ser Gly Lys Met Tyr Phe Gln Thr Met 
        515                 520                 525             


Thr Glu Ala Glu Tyr Gln Thr Ser Ile Gln Glu Lys Leu Pro Leu Ile 
    530                 535                 540                 


Ile Gly Ser Ser Ala Ala Gly Leu Val Phe Leu Ile Ala Val Val Val 
545                 550                 555                 560 


Ile Ala Ile Val Cys Asn Arg Arg Gly Phe Glu Arg Ala Asp Ser Glu 
                565                 570                 575     


Tyr Thr Asp Lys Leu Gln His Tyr Thr Ser Gly His Met Thr Pro Gly 
            580                 585                 590         


Met Lys Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala 
        595                 600                 605             


Val Arg Glu Phe Ala Lys Glu Ile Asp Ile Ser Cys Val Lys Ile Glu 
    610                 615                 620                 


Gln Val Ile Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly His Leu 
625                 630                 635                 640 


Lys Leu Pro Gly Lys Arg Glu Ile Phe Val Ala Ile Lys Thr Leu Lys 
                645                 650                 655     


Ser Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser 
            660                 665                 670         


Ile Met Gly Gln Phe Asp His Pro Asn Val Ile His Leu Glu Gly Val 
        675                 680                 685             


Val Thr Lys Ser Thr Pro Val Met Ile Ile Thr Glu Phe Met Glu Asn 
    690                 695                 700                 


Gly Ser Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr Val 
705                 710                 715                 720 


Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr 
                725                 730                 735     


Leu Ala Asp Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile 
            740                 745                 750         


Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser 
        755                 760                 765             


Arg Phe Leu Glu Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ala Leu 
    770                 775                 780                 


Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Gln Tyr 
785                 790                 795                 800 


Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met 
                805                 810                 815     


Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Thr Asn 
            820                 825                 830         


Gln Asp Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro 
        835                 840                 845             


Met Asp Cys Pro Ser Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln 
    850                 855                 860                 


Lys Asp Arg Asn His Arg Pro Lys Phe Gly Gln Ile Val Asn Thr Leu 
865                 870                 875                 880 


Asp Lys Met Ile Arg Asn Pro Asn Ser Leu Lys Ala Met Ala Pro Leu 
                885                 890                 895     


Ser Ser Gly Ile Asn Leu Pro Leu Leu Asp Arg Thr Ile Pro Asp Tyr 
            900                 905                 910         


Thr Ser Phe Asn Thr Val Asp Glu Trp Leu Glu Ala Ile Lys Met Gly 
        915                 920                 925             


Gln Tyr Lys Glu Ser Phe Ala Asn Ala Gly Phe Thr Ser Phe Asp Val 
    930                 935                 940                 


Val Ser Gln Met Met Met Glu Asp Ile Leu Arg Val Gly Val Thr Leu 
945                 950                 955                 960 


Ala Gly His Gln Lys Lys Ile Leu Asn Ser Ile Gln Val Met Arg Ala 
                965                 970                 975     


Gln Met Asn Gln Ile Gln Ser Val Glu Val 
            980                 985     


<210>  4295
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  4295

Met Ser Gly Ser Ser Leu Pro Ser Ala Leu Ala Leu Ser Leu Leu Leu 
1               5                   10                  15      


Val Ser Gly Ser Leu Leu Pro Gly Pro Gly Ala Ala Gln Asn Glu Pro 
            20                  25                  30          


Arg Ile Val Thr Ser Glu Glu Val Ile Ile Arg Asp Ser Pro Val Leu 
        35                  40                  45              


Pro Val Thr Leu Gln Cys Asn Leu Thr Ser Ser Ser His Thr Leu Thr 
    50                  55                  60                  


Tyr Ser Tyr Trp Thr Lys Asn Gly Val Glu Leu Ser Ala Thr Arg Lys 
65                  70                  75                  80  


Asn Ala Ser Asn Met Glu Tyr Arg Ile Asn Lys Pro Arg Ala Glu Asp 
                85                  90                  95      


Ser Gly Glu Tyr His Cys Val Tyr His Phe Val Ser Ala Pro Lys Ala 
            100                 105                 110         


Asn Ala Thr Ile Glu Val Lys Ala Ala Pro Asp Ile Thr Gly His Lys 
        115                 120                 125             


Arg Ser Glu Asn Lys Asn Glu Gly Gln Asp Ala Thr Met Tyr Cys Lys 
    130                 135                 140                 


Ser Val Gly Tyr Pro His Pro Asp Trp Ile Trp Arg Lys Lys Glu Asn 
145                 150                 155                 160 


Gly Met Pro Met Asp Ile Val Asn Thr Ser Gly Arg Phe Phe Ile Ile 
                165                 170                 175     


Asn Lys Glu Asn Tyr Thr Glu Leu Asn Ile Val Asn Leu Gln Ile Thr 
            180                 185                 190         


Glu Asp Pro Gly Glu Tyr Glu Cys Asn Ala Thr Asn Ala Ile Gly Ser 
        195                 200                 205             


Ala Ser Val Val Thr Val Leu Arg Val Arg Ser His Leu Ala Pro Leu 
    210                 215                 220                 


Trp Pro Phe Leu Gly Ile Leu Ala Glu Ile Ile Ile Leu Val Val Ile 
225                 230                 235                 240 


Ile Val Val Tyr Glu Lys Arg Lys Arg Pro Asp Glu Val Pro Asp Asp 
                245                 250                 255     


Asp Glu Pro Ala Gly Pro Met Lys Thr Asn Ser Thr Asn Asn His Lys 
            260                 265                 270         


Asp Lys Asn Leu Arg Gln Arg Asn Thr Asn 
        275                 280         


<210>  4296
<211>  503
<212>  PRT
<213>  Homo sapiens

<400>  4296

Met Ala Leu Ile Pro Asp Leu Ala Met Glu Thr Trp Leu Leu Leu Ala 
1               5                   10                  15      


Val Ser Leu Val Leu Leu Tyr Leu Tyr Gly Thr His Ser His Gly Leu 
            20                  25                  30          


Phe Lys Lys Leu Gly Ile Pro Gly Pro Thr Pro Leu Pro Phe Leu Gly 
        35                  40                  45              


Asn Ile Leu Ser Tyr His Lys Gly Phe Cys Met Phe Asp Met Glu Cys 
    50                  55                  60                  


His Lys Lys Tyr Gly Lys Val Trp Gly Phe Tyr Asp Gly Gln Gln Pro 
65                  70                  75                  80  


Val Leu Ala Ile Thr Asp Pro Asp Met Ile Lys Thr Val Leu Val Lys 
                85                  90                  95      


Glu Cys Tyr Ser Val Phe Thr Asn Arg Arg Pro Phe Gly Pro Val Gly 
            100                 105                 110         


Phe Met Lys Ser Ala Ile Ser Ile Ala Glu Asp Glu Glu Trp Lys Arg 
        115                 120                 125             


Leu Arg Ser Leu Leu Ser Pro Thr Phe Thr Ser Gly Lys Leu Lys Glu 
    130                 135                 140                 


Met Val Pro Ile Ile Ala Gln Tyr Gly Asp Val Leu Val Arg Asn Leu 
145                 150                 155                 160 


Arg Arg Glu Ala Glu Thr Gly Lys Pro Val Thr Leu Lys Asp Val Phe 
                165                 170                 175     


Gly Ala Tyr Ser Met Asp Val Ile Thr Ser Thr Ser Phe Gly Val Asn 
            180                 185                 190         


Ile Asp Ser Leu Asn Asn Pro Gln Asp Pro Phe Val Glu Asn Thr Lys 
        195                 200                 205             


Lys Leu Leu Arg Phe Asp Phe Leu Asp Pro Phe Phe Leu Ser Ile Thr 
    210                 215                 220                 


Val Phe Pro Phe Leu Ile Pro Ile Leu Glu Val Leu Asn Ile Cys Val 
225                 230                 235                 240 


Phe Pro Arg Glu Val Thr Asn Phe Leu Arg Lys Ser Val Lys Arg Met 
                245                 250                 255     


Lys Glu Ser Arg Leu Glu Asp Thr Gln Lys His Arg Val Asp Phe Leu 
            260                 265                 270         


Gln Leu Met Ile Asp Ser Gln Asn Ser Lys Glu Thr Glu Ser His Lys 
        275                 280                 285             


Ala Leu Ser Asp Leu Glu Leu Val Ala Gln Ser Ile Ile Phe Ile Phe 
    290                 295                 300                 


Ala Gly Tyr Glu Thr Thr Ser Ser Val Leu Ser Phe Ile Met Tyr Glu 
305                 310                 315                 320 


Leu Ala Thr His Pro Asp Val Gln Gln Lys Leu Gln Glu Glu Ile Asp 
                325                 330                 335     


Ala Val Leu Pro Asn Lys Ala Pro Pro Thr Tyr Asp Thr Val Leu Gln 
            340                 345                 350         


Met Glu Tyr Leu Asp Met Val Val Asn Glu Thr Leu Arg Leu Phe Pro 
        355                 360                 365             


Ile Ala Met Arg Leu Glu Arg Val Cys Lys Lys Asp Val Glu Ile Asn 
    370                 375                 380                 


Gly Met Phe Ile Pro Lys Gly Val Val Val Met Ile Pro Ser Tyr Ala 
385                 390                 395                 400 


Leu His Arg Asp Pro Lys Tyr Trp Thr Glu Pro Glu Lys Phe Leu Pro 
                405                 410                 415     


Glu Arg Phe Ser Lys Lys Asn Lys Asp Asn Ile Asp Pro Tyr Ile Tyr 
            420                 425                 430         


Thr Pro Phe Gly Ser Gly Pro Arg Asn Cys Ile Gly Met Arg Phe Ala 
        435                 440                 445             


Leu Met Asn Met Lys Leu Ala Leu Ile Arg Val Leu Gln Asn Phe Ser 
    450                 455                 460                 


Phe Lys Pro Cys Lys Glu Thr Gln Ile Pro Leu Lys Leu Ser Leu Gly 
465                 470                 475                 480 


Gly Leu Leu Gln Pro Glu Lys Pro Val Val Leu Lys Val Glu Ser Arg 
                485                 490                 495     


Asp Gly Thr Val Ser Gly Ala 
            500             


<210>  4297
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  4297

Met Val Trp Glu Asn Gln Thr Phe Asn Ser Ile Phe Ile Leu Leu Gly 
1               5                   10                  15      


Ile Phe Asn His Ser Pro Thr His Thr Phe Leu Phe Ser Leu Val Leu 
            20                  25                  30          


Gly Ile Phe Ser Leu Ala Leu Met Glu Asn Ile Ser Met Val Leu Leu 
        35                  40                  45              


Ile Tyr Ile Glu Lys Gln Leu His Thr Pro Met Tyr Phe Leu Leu Ser 
    50                  55                  60                  


Gln Leu Ser Leu Met Asp Leu Met Leu Ile Cys Thr Thr Leu Pro Lys 
65                  70                  75                  80  


Met Ile Phe Ser Tyr Leu Ser Gly Lys Lys Ser Ile Ser Leu Ala Gly 
                85                  90                  95      


Cys Gly Thr Gln Ile Phe Phe Tyr Val Ser Leu Leu Gly Ala Glu Cys 
            100                 105                 110         


Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 
        115                 120                 125             


Pro Leu Gln Tyr Thr Ile Leu Met Asn Pro Lys Leu Cys Val Phe Met 
    130                 135                 140                 


Thr Val Ala Ser Trp Thr Leu Gly Ser Leu Asp Gly Ile Ile Val Leu 
145                 150                 155                 160 


Ala Ala Val Leu Ser Phe Ser Tyr Cys Ser Ser Leu Glu Ile His His 
                165                 170                 175     


Phe Phe Cys Asp Val Ala Ala Leu Leu Pro Leu Ser Cys Thr Glu Thr 
            180                 185                 190         


Ser Ala Phe Glu Arg Leu Leu Val Ile Cys Cys Val Val Met Leu Ile 
        195                 200                 205             


Phe Pro Val Ser Val Ile Ile Leu Ser Tyr Ser His Val Leu Arg Ala 
    210                 215                 220                 


Val Ile His Met Gly Ser Gly Glu Ser Arg Arg Lys Ala Phe Thr Thr 
225                 230                 235                 240 


Cys Ser Ser His Leu Ser Val Val Gly Leu Tyr Tyr Gly Ala Ala Met 
                245                 250                 255     


Phe Met Tyr Met Arg Pro Ala Ser Lys His Thr Pro Asp Gln Asp Lys 
            260                 265                 270         


Met Val Ser Ala Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Leu 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Glu Val Phe Arg Ala Leu Gln Lys Val 
    290                 295                 300                 


Leu Lys Lys Arg Lys Leu Ile 
305                 310     


<210>  4298
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  4298

Met Glu Pro Gly Asn Asp Thr Gln Ile Ser Glu Phe Leu Leu Leu Gly 
1               5                   10                  15      


Phe Ser Gln Glu Pro Gly Leu Gln Pro Phe Leu Phe Gly Leu Phe Leu 
            20                  25                  30          


Ser Met Tyr Leu Val Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Ala 
        35                  40                  45              


Thr Ile Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 
    50                  55                  60                  


Asn Leu Ser Phe Ala Asp Ile Cys Val Thr Ser Thr Thr Ile Pro Lys 
65                  70                  75                  80  


Met Leu Met Asn Ile Gln Thr Gln Asn Lys Val Ile Thr Tyr Ile Ala 
                85                  90                  95      


Cys Leu Met Gln Met Tyr Phe Phe Ile Leu Phe Ala Gly Phe Glu Asn 
            100                 105                 110         


Phe Leu Leu Ser Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 
        115                 120                 125             


Pro Leu His Tyr Met Val Ile Met Asn Pro His Leu Cys Gly Leu Leu 
    130                 135                 140                 


Val Leu Ala Ser Trp Thr Met Ser Ala Leu Tyr Ser Leu Leu Gln Ile 
145                 150                 155                 160 


Leu Met Val Val Arg Leu Ser Phe Cys Thr Ala Leu Glu Ile Pro His 
                165                 170                 175     


Phe Phe Cys Glu Leu Asn Gln Val Ile Gln Leu Ala Cys Ser Asp Ser 
            180                 185                 190         


Phe Leu Asn His Met Val Ile Tyr Phe Thr Val Ala Leu Leu Gly Gly 
        195                 200                 205             


Gly Pro Leu Thr Gly Ile Leu Tyr Ser Tyr Ser Lys Ile Ile Ser Ser 
    210                 215                 220                 


Ile His Ala Ile Ser Ser Ala Gln Gly Lys Tyr Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Ala Ile Leu 
                245                 250                 255     


Gly Val Tyr Leu Ser Ser Ala Ala Thr Arg Asn Ser His Ser Ser Ala 
            260                 265                 270         


Thr Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Arg Ala Leu Gly Ile His 
    290                 295                 300                 


Leu Leu Trp Gly Thr Met Lys Gly Gln Phe Phe Lys Lys Cys Pro 
305                 310                 315                 


<210>  4299
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  4299

Met Glu Ala Asp Ser Pro Ala Gly Pro Gly Ala Pro Glu Pro Leu Ala 
1               5                   10                  15      


Glu Gly Ala Ala Ala Glu Phe Ser Ser Leu Leu Arg Arg Ile Lys Gly 
            20                  25                  30          


Lys Leu Phe Thr Trp Asn Ile Leu Lys Thr Ile Ala Leu Gly Gln Met 
        35                  40                  45              


Leu Ser Leu Cys Ile Cys Gly Thr Ala Ile Thr Ser Gln Tyr Leu Ala 
    50                  55                  60                  


Glu Arg Tyr Lys Val Asn Thr Pro Met Leu Gln Ser Phe Ile Asn Tyr 
65                  70                  75                  80  


Cys Leu Leu Phe Leu Ile Tyr Thr Val Met Leu Ala Phe Arg Ser Gly 
                85                  90                  95      


Ser Asp Asn Leu Leu Val Ile Leu Lys Arg Lys Trp Trp Lys Tyr Ile 
            100                 105                 110         


Leu Leu Gly Leu Ala Asp Val Glu Ala Asn Tyr Val Ile Val Arg Ala 
        115                 120                 125             


Tyr Gln Tyr Thr Thr Leu Thr Ser Val Gln Leu Leu Asp Cys Phe Gly 
    130                 135                 140                 


Ile Pro Val Leu Met Ala Leu Ser Trp Phe Ile Leu His Ala Arg Tyr 
145                 150                 155                 160 


Arg Val Ile His Phe Ile Ala Val Ala Val Cys Leu Leu Gly Val Gly 
                165                 170                 175     


Thr Met Val Gly Ala Asp Ile Leu Ala Gly Arg Glu Asp Asn Ser Gly 
            180                 185                 190         


Ser Asp Val Leu Ile Gly Asp Ile Leu Val Leu Leu Gly Ala Ser Leu 
        195                 200                 205             


Tyr Ala Ile Ser Asn Val Cys Glu Glu Tyr Ile Val Lys Lys Leu Ser 
    210                 215                 220                 


Arg Gln Glu Phe Leu Gly Met Val Gly Leu Phe Gly Thr Ile Ile Ser 
225                 230                 235                 240 


Gly Ile Gln Leu Leu Ile Val Glu Tyr Lys Asp Ile Ala Ser Ile His 
                245                 250                 255     


Trp Asp Trp Lys Ile Ala Leu Leu Phe Val Ala Phe Ala Leu Cys Met 
            260                 265                 270         


Phe Cys Leu Tyr Ser Phe Met Pro Leu Val Ile Lys Val Thr Ser Ala 
        275                 280                 285             


Thr Ser Val Asn Leu Gly Ile Leu Thr Ala Asp Leu Tyr Ser Leu Phe 
    290                 295                 300                 


Val Gly Leu Phe Leu Phe Gly Tyr Lys Phe Ser Gly Leu Tyr Ile Leu 
305                 310                 315                 320 


Ser Phe Thr Val Ile Met Val Gly Phe Ile Leu Tyr Cys Ser Thr Pro 
                325                 330                 335     


Thr Arg Thr Ala Glu Pro Ala Glu Ser Ser Val Pro Pro Val Thr Ser 
            340                 345                 350         


Ile Gly Ile Asp Asn Leu Gly Leu Lys Leu Glu Glu Asn Leu Gln Glu 
        355                 360                 365             


Thr His Ser Ala Val Leu 
    370                 


<210>  4300
<211>  700
<212>  PRT
<213>  Homo sapiens

<400>  4300

Met Gly Leu Pro Glu Pro Gly Pro Leu Arg Leu Leu Ala Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Gln Leu Gln His Leu Ala Ala Ala 
            20                  25                  30          


Ala Ala Asp Pro Leu Leu Gly Gly Gln Gly Pro Ala Lys Asp Cys Glu 
        35                  40                  45              


Lys Asp Gln Phe Gln Cys Arg Asn Glu Arg Cys Ile Pro Ser Val Trp 
    50                  55                  60                  


Arg Cys Asp Glu Asp Asp Asp Cys Leu Asp His Ser Asp Glu Asp Asp 
65                  70                  75                  80  


Cys Pro Lys Lys Thr Cys Ala Asp Ser Asp Phe Thr Cys Asp Asn Gly 
                85                  90                  95      


His Cys Ile His Glu Arg Trp Lys Cys Asp Gly Glu Glu Glu Cys Pro 
            100                 105                 110         


Asp Gly Ser Asp Glu Ser Glu Ala Thr Cys Thr Lys Gln Val Cys Pro 
        115                 120                 125             


Ala Glu Lys Leu Ser Cys Gly Pro Thr Ser His Lys Cys Val Pro Ala 
    130                 135                 140                 


Ser Trp Arg Cys Asp Gly Glu Lys Asp Cys Glu Gly Gly Ala Asp Glu 
145                 150                 155                 160 


Ala Gly Cys Ala Thr Ser Leu Gly Thr Cys Arg Gly Asp Glu Phe Gln 
                165                 170                 175     


Cys Gly Asp Gly Thr Cys Val Leu Ala Ile Lys His Cys Asn Gln Glu 
            180                 185                 190         


Gln Asp Cys Pro Asp Gly Ser Asp Glu Ala Gly Cys Leu Gln Gly Leu 
        195                 200                 205             


Asn Glu Cys Leu His Asn Asn Gly Gly Cys Ser His Ile Cys Thr Asp 
    210                 215                 220                 


Leu Lys Ile Gly Phe Glu Cys Thr Cys Pro Ala Gly Phe Gln Leu Leu 
225                 230                 235                 240 


Asp Gln Lys Thr Cys Gly Asp Ile Asp Glu Cys Lys Asp Pro Asp Ala 
                245                 250                 255     


Cys Ser Gln Ile Cys Val Asn Tyr Lys Gly Tyr Phe Lys Cys Glu Cys 
            260                 265                 270         


Tyr Pro Gly Tyr Glu Met Asp Leu Leu Thr Lys Asn Cys Lys Ala Ala 
        275                 280                 285             


Ala Gly Lys Ser Pro Ser Leu Ile Phe Thr Asn Arg His Glu Val Arg 
    290                 295                 300                 


Arg Ile Asp Leu Val Lys Arg Asn Tyr Ser Arg Leu Ile Pro Met Leu 
305                 310                 315                 320 


Lys Asn Val Val Ala Leu Asp Val Glu Val Ala Thr Asn Arg Ile Tyr 
                325                 330                 335     


Trp Cys Asp Leu Ser Tyr Arg Lys Ile Tyr Ser Ala Tyr Met Asp Lys 
            340                 345                 350         


Ala Ser Asp Pro Lys Glu Gln Glu Val Leu Ile Asp Glu Gln Leu His 
        355                 360                 365             


Ser Pro Glu Gly Leu Ala Val Asp Trp Val His Lys His Ile Tyr Trp 
    370                 375                 380                 


Thr Asp Ser Gly Asn Lys Thr Ile Ser Val Ala Thr Val Asp Gly Gly 
385                 390                 395                 400 


Arg Arg Arg Thr Leu Phe Ser Arg Asn Leu Ser Glu Pro Arg Ala Ile 
                405                 410                 415     


Ala Val Asp Pro Leu Arg Gly Phe Met Tyr Trp Ser Asp Trp Gly Asp 
            420                 425                 430         


Gln Ala Lys Ile Glu Lys Ser Gly Leu Asn Gly Val Asp Arg Gln Thr 
        435                 440                 445             


Leu Val Ser Asp Asn Ile Glu Trp Pro Asn Gly Ile Thr Leu Asp Leu 
    450                 455                 460                 


Leu Ser Gln Arg Leu Tyr Trp Val Asp Ser Lys Leu His Gln Leu Ser 
465                 470                 475                 480 


Ser Ile Asp Phe Ser Gly Gly Asn Arg Lys Thr Leu Ile Ser Ser Thr 
                485                 490                 495     


Asp Phe Leu Ser His Pro Phe Gly Ile Ala Val Phe Glu Asp Lys Val 
            500                 505                 510         


Phe Trp Thr Asp Leu Glu Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu 
        515                 520                 525             


Asn Gly Leu Glu Ile Ser Ile Leu Ala Glu Asn Leu Asn Asn Pro His 
    530                 535                 540                 


Asp Ile Val Ile Phe His Glu Leu Lys Gln Pro Arg Ala Pro Asp Ala 
545                 550                 555                 560 


Cys Glu Leu Ser Val Gln Pro Asn Gly Gly Cys Glu Tyr Leu Cys Leu 
                565                 570                 575     


Pro Ala Pro Gln Ile Ser Ser His Ser Pro Lys Tyr Thr Cys Ala Cys 
            580                 585                 590         


Pro Asp Thr Met Trp Leu Gly Pro Asp Met Lys Arg Cys Tyr Arg Asp 
        595                 600                 605             


Ala Asn Glu Asp Ser Lys Met Gly Ser Thr Val Thr Ala Ala Val Ile 
    610                 615                 620                 


Gly Ile Ile Val Pro Ile Val Val Ile Ala Leu Leu Cys Met Ser Gly 
625                 630                 635                 640 


Tyr Leu Ile Trp Arg Asn Trp Lys Arg Lys Asn Thr Lys Ser Met Asn 
                645                 650                 655     


Phe Asp Asn Pro Val Tyr Arg Lys Thr Thr Glu Glu Glu Asp Glu Asp 
            660                 665                 670         


Glu Leu His Ile Gly Arg Thr Ala Gln Ile Gly His Val Tyr Pro Ala 
        675                 680                 685             


Arg Val Ala Leu Ser Leu Glu Asp Asp Gly Leu Pro 
    690                 695                 700 


<210>  4301
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  4301

Met Ala Gly Val Lys Ala Leu Val Ala Leu Ser Phe Ser Gly Ala Ile 
1               5                   10                  15      


Gly Leu Thr Phe Leu Met Leu Gly Cys Ala Leu Glu Asp Tyr Gly Val 
            20                  25                  30          


Tyr Trp Pro Leu Phe Val Leu Ile Phe His Ala Ile Ser Pro Ile Pro 
        35                  40                  45              


His Phe Ile Ala Lys Arg Val Thr Tyr Asp Ser Asp Ala Thr Ser Ser 
    50                  55                  60                  


Ala Cys Arg Glu Leu Ala Tyr Phe Phe Thr Thr Gly Ile Val Val Ser 
65                  70                  75                  80  


Ala Phe Gly Phe Pro Val Ile Leu Ala Arg Val Ala Val Ile Lys Trp 
                85                  90                  95      


Gly Ala Cys Gly Leu Val Leu Ala Gly Asn Ala Val Ile Phe Leu Thr 
            100                 105                 110         


Ile Gln Gly Phe Phe Leu Ile Phe Gly Arg Gly Asp Asp Phe Ser Trp 
        115                 120                 125             


Glu Gln Trp 
    130     


<210>  4302
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  4302

Met Ala Leu Leu Ala Leu Leu Leu Val Val Ala Leu Pro Arg Val Trp 
1               5                   10                  15      


Thr Asp Ala Asn Leu Thr Ala Arg Gln Arg Asp Pro Glu Asp Ser Gln 
            20                  25                  30          


Arg Thr Asp Glu Gly Asp Asn Arg Val Trp Cys His Val Cys Glu Arg 
        35                  40                  45              


Glu Asn Thr Phe Glu Cys Gln Asn Pro Arg Arg Cys Lys Trp Thr Glu 
    50                  55                  60                  


Pro Tyr Cys Val Ile Ala Ala Val Lys Ile Phe Pro Arg Phe Phe Met 
65                  70                  75                  80  


Val Ala Lys Gln Cys Ser Ala Gly Cys Ala Ala Met Glu Arg Pro Lys 
                85                  90                  95      


Pro Glu Glu Lys Arg Phe Leu Leu Glu Glu Pro Met Pro Phe Phe Tyr 
            100                 105                 110         


Leu Lys Cys Cys Lys Ile Arg Tyr Cys Asn Leu Glu Gly Pro Pro Ile 
        115                 120                 125             


Asn Ser Ser Val Phe Lys Glu Tyr Ala Gly Ser Met Gly Glu Ser Cys 
    130                 135                 140                 


Gly Gly Leu Trp Leu Ala Ile Leu Leu Leu Leu Ala Ser Ile Ala Ala 
145                 150                 155                 160 


Gly Leu Ser Leu Ser 
                165 


<210>  4303
<211>  603
<212>  PRT
<213>  Homo sapiens

<400>  4303

Met Arg Arg Lys Glu Lys Arg Leu Leu Gln Ala Val Ala Leu Val Leu 
1               5                   10                  15      


Ala Ala Leu Val Leu Leu Pro Asn Val Gly Leu Trp Ala Leu Tyr Arg 
            20                  25                  30          


Glu Arg Gln Pro Asp Gly Thr Pro Gly Gly Ser Gly Ala Ala Val Ala 
        35                  40                  45              


Pro Ala Ala Gly Gln Gly Ser His Ser Arg Gln Lys Lys Thr Phe Phe 
    50                  55                  60                  


Leu Gly Asp Gly Gln Lys Leu Lys Asp Trp His Asp Lys Glu Ala Ile 
65                  70                  75                  80  


Arg Arg Asp Ala Gln Arg Val Gly Asn Gly Glu Gln Gly Arg Pro Tyr 
                85                  90                  95      


Pro Met Thr Asp Ala Glu Arg Val Asp Gln Ala Tyr Arg Glu Asn Gly 
            100                 105                 110         


Phe Asn Ile Tyr Val Ser Asp Lys Ile Ser Leu Asn Arg Ser Leu Pro 
        115                 120                 125             


Asp Ile Arg His Pro Asn Cys Asn Ser Lys Arg Tyr Leu Glu Thr Leu 
    130                 135                 140                 


Pro Asn Thr Ser Ile Ile Ile Pro Phe His Asn Glu Gly Trp Ser Ser 
145                 150                 155                 160 


Leu Leu Arg Thr Val His Ser Val Leu Asn Arg Ser Pro Pro Glu Leu 
                165                 170                 175     


Val Ala Glu Ile Val Leu Val Asp Asp Phe Ser Asp Arg Glu His Leu 
            180                 185                 190         


Lys Lys Pro Leu Glu Asp Tyr Met Ala Leu Phe Pro Ser Val Arg Ile 
        195                 200                 205             


Leu Arg Thr Lys Lys Arg Glu Gly Leu Ile Arg Thr Arg Met Leu Gly 
    210                 215                 220                 


Ala Ser Val Ala Thr Gly Asp Val Ile Thr Phe Leu Asp Ser His Cys 
225                 230                 235                 240 


Glu Ala Asn Val Asn Trp Leu Pro Pro Leu Leu Asp Arg Ile Ala Arg 
                245                 250                 255     


Asn Arg Lys Thr Ile Val Cys Pro Met Ile Asp Val Ile Asp His Asp 
            260                 265                 270         


Asp Phe Arg Tyr Glu Thr Gln Ala Gly Asp Ala Met Arg Gly Ala Phe 
        275                 280                 285             


Asp Trp Glu Met Tyr Tyr Lys Arg Ile Pro Ile Pro Pro Glu Leu Gln 
    290                 295                 300                 


Lys Ala Asp Pro Ser Asp Pro Phe Glu Ser Pro Val Met Ala Gly Gly 
305                 310                 315                 320 


Leu Phe Ala Val Asp Arg Lys Trp Phe Trp Glu Leu Gly Gly Tyr Asp 
                325                 330                 335     


Pro Gly Leu Glu Ile Trp Gly Gly Glu Gln Tyr Glu Ile Ser Phe Lys 
            340                 345                 350         


Val Trp Met Cys Gly Gly Arg Met Glu Asp Ile Pro Cys Ser Arg Val 
        355                 360                 365             


Gly His Ile Tyr Arg Lys Tyr Val Pro Tyr Lys Val Pro Ala Gly Val 
    370                 375                 380                 


Ser Leu Ala Arg Asn Leu Lys Arg Val Ala Glu Val Trp Met Asp Glu 
385                 390                 395                 400 


Tyr Ala Glu Tyr Ile Tyr Gln Arg Arg Pro Glu Tyr Arg His Leu Ser 
                405                 410                 415     


Ala Gly Asp Val Ala Val Gln Lys Lys Leu Arg Ser Ser Leu Asn Cys 
            420                 425                 430         


Lys Ser Phe Lys Trp Phe Met Thr Lys Ile Ala Trp Asp Leu Pro Lys 
        435                 440                 445             


Phe Tyr Pro Pro Val Glu Pro Pro Ala Ala Ala Trp Gly Glu Ile Arg 
    450                 455                 460                 


Asn Val Gly Thr Gly Leu Cys Ala Asp Thr Lys His Gly Ala Leu Gly 
465                 470                 475                 480 


Ser Pro Leu Arg Leu Glu Gly Cys Val Arg Gly Arg Gly Glu Ala Ala 
                485                 490                 495     


Trp Asn Asn Met Gln Val Phe Thr Phe Thr Trp Arg Glu Asp Ile Arg 
            500                 505                 510         


Pro Gly Asp Pro Gln His Thr Lys Lys Phe Cys Phe Asp Ala Ile Ser 
        515                 520                 525             


His Thr Ser Pro Val Thr Leu Tyr Asp Cys His Ser Met Lys Gly Asn 
    530                 535                 540                 


Gln Leu Trp Lys Tyr Arg Lys Asp Lys Thr Leu Tyr His Pro Val Ser 
545                 550                 555                 560 


Gly Ser Cys Met Asp Cys Ser Glu Ser Asp His Arg Ile Phe Met Asn 
                565                 570                 575     


Thr Cys Asn Pro Ser Ser Leu Thr Gln Gln Trp Leu Phe Glu His Thr 
            580                 585                 590         


Asn Ser Thr Val Leu Glu Lys Phe Asn Arg Asn 
        595                 600             


<210>  4304
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  4304

Met Pro Gly Arg Ala Pro Leu Arg Thr Val Pro Gly Ala Leu Gly Ala 
1               5                   10                  15      


Trp Leu Leu Gly Gly Leu Trp Ala Trp Thr Leu Cys Gly Leu Cys Ser 
            20                  25                  30          


Leu Gly Ala Val Gly Ala Pro Arg Pro Cys Gln Ala Pro Gln Gln Trp 
        35                  40                  45              


Glu Gly Arg Gln Val Met Tyr Gln Gln Ser Ser Gly Arg Asn Ser Arg 
    50                  55                  60                  


Ala Leu Leu Ser Tyr Asp Gly Leu Asn Gln Arg Val Arg Val Leu Asp 
65                  70                  75                  80  


Glu Arg Lys Ala Leu Ile Pro Cys Lys Arg Leu Phe Glu Tyr Ile Leu 
                85                  90                  95      


Leu Tyr Lys Asp Gly Val Met Phe Gln Ile Asp Gln Ala Thr Lys Gln 
            100                 105                 110         


Cys Ser Lys Met Thr Leu Thr Gln Pro Trp Asp Pro Leu Asp Ile Pro 
        115                 120                 125             


Gln Asn Ser Thr Phe Glu Asp Gln Tyr Ser Ile Gly Gly Pro Gln Glu 
    130                 135                 140                 


Gln Ile Thr Val Gln Glu Trp Ser Asp Arg Lys Ser Ala Arg Ser Tyr 
145                 150                 155                 160 


Glu Thr Trp Ile Gly Ile Tyr Thr Val Lys Asp Cys Tyr Pro Val Gln 
                165                 170                 175     


Glu Thr Phe Thr Ile Asn Tyr Ser Val Ile Leu Ser Thr Arg Phe Phe 
            180                 185                 190         


Asp Ile Gln Leu Gly Ile Lys Asp Pro Ser Val Phe Thr Pro Pro Ser 
        195                 200                 205             


Thr Cys Gln Met Ala Gln Leu Glu Lys Met Ser Glu Asp Cys Ser Trp 
    210                 215                 220                 


<210>  4305
<211>  1009
<212>  PRT
<213>  Homo sapiens

<400>  4305

Met Glu Ala Leu Thr Leu Trp Leu Leu Pro Trp Ile Cys Gln Cys Val 
1               5                   10                  15      


Ser Val Arg Ala Asp Ser Ile Ile His Ile Gly Ala Ile Phe Glu Glu 
            20                  25                  30          


Asn Ala Ala Lys Asp Asp Arg Val Phe Gln Leu Ala Val Ser Asp Leu 
        35                  40                  45              


Ser Leu Asn Asp Asp Ile Leu Gln Ser Glu Lys Ile Thr Tyr Ser Ile 
    50                  55                  60                  


Lys Val Ile Glu Ala Asn Asn Pro Phe Gln Ala Val Gln Glu Ala Cys 
65                  70                  75                  80  


Asp Leu Met Thr Gln Gly Ile Leu Ala Leu Val Thr Ser Thr Gly Cys 
                85                  90                  95      


Ala Ser Ala Asn Ala Leu Gln Ser Leu Thr Asp Ala Met His Ile Pro 
            100                 105                 110         


His Leu Phe Val Gln Arg Asn Pro Gly Gly Ser Pro Arg Thr Ala Cys 
        115                 120                 125             


His Leu Asn Pro Ser Pro Asp Gly Glu Ala Tyr Thr Leu Ala Ser Arg 
    130                 135                 140                 


Pro Pro Val Arg Leu Asn Asp Val Met Leu Arg Leu Val Thr Glu Leu 
145                 150                 155                 160 


Arg Trp Gln Lys Phe Val Met Phe Tyr Asp Ser Glu Tyr Asp Ile Arg 
                165                 170                 175     


Gly Leu Gln Ser Phe Leu Asp Gln Ala Ser Arg Leu Gly Leu Asp Val 
            180                 185                 190         


Ser Leu Gln Lys Val Asp Lys Asn Ile Ser His Val Phe Thr Ser Leu 
        195                 200                 205             


Phe Thr Thr Met Lys Thr Glu Glu Leu Asn Arg Tyr Arg Asp Thr Leu 
    210                 215                 220                 


Arg Arg Ala Ile Leu Leu Leu Ser Pro Gln Gly Ala His Ser Phe Ile 
225                 230                 235                 240 


Asn Glu Ala Val Glu Thr Asn Leu Ala Ser Lys Asp Ser His Trp Val 
                245                 250                 255     


Phe Val Asn Glu Glu Ile Ser Asp Pro Glu Ile Leu Asp Leu Val His 
            260                 265                 270         


Ser Ala Leu Gly Arg Met Thr Val Val Arg Gln Ile Phe Pro Ser Ala 
        275                 280                 285             


Lys Asp Asn Gln Lys Cys Thr Arg Asn Asn His Arg Ile Ser Ser Leu 
    290                 295                 300                 


Leu Cys Asp Pro Gln Glu Gly Tyr Leu Gln Met Leu Gln Ile Ser Asn 
305                 310                 315                 320 


Leu Tyr Leu Tyr Asp Ser Val Leu Met Leu Ala Asn Ala Phe His Arg 
                325                 330                 335     


Lys Leu Glu Asp Arg Lys Trp His Ser Met Ala Ser Leu Asn Cys Ile 
            340                 345                 350         


Arg Lys Ser Thr Lys Pro Trp Asn Gly Gly Arg Ser Met Leu Asp Thr 
        355                 360                 365             


Ile Lys Lys Gly His Ile Thr Gly Leu Thr Gly Val Met Glu Phe Arg 
    370                 375                 380                 


Glu Asp Ser Ser Asn Pro Tyr Val Gln Phe Glu Ile Leu Gly Thr Thr 
385                 390                 395                 400 


Tyr Ser Glu Thr Phe Gly Lys Asp Met Arg Lys Leu Ala Thr Trp Asp 
                405                 410                 415     


Ser Glu Lys Gly Leu Asn Gly Ser Leu Gln Glu Arg Pro Met Gly Ser 
            420                 425                 430         


Arg Leu Gln Gly Leu Thr Leu Lys Val Val Thr Val Leu Glu Glu Pro 
        435                 440                 445             


Phe Val Met Val Ala Glu Asn Ile Leu Gly Gln Pro Lys Arg Tyr Lys 
    450                 455                 460                 


Gly Phe Ser Ile Asp Val Leu Asp Ala Leu Ala Lys Ala Leu Gly Phe 
465                 470                 475                 480 


Lys Tyr Glu Ile Tyr Gln Ala Pro Asp Gly Arg Tyr Gly His Gln Leu 
                485                 490                 495     


His Asn Thr Ser Trp Asn Gly Met Ile Gly Glu Leu Ile Ser Lys Arg 
            500                 505                 510         


Ala Asp Leu Ala Ile Ser Ala Ile Thr Ile Thr Pro Glu Arg Glu Ser 
        515                 520                 525             


Val Val Asp Phe Ser Lys Arg Tyr Met Asp Tyr Ser Val Gly Ile Leu 
    530                 535                 540                 


Ile Lys Lys Pro Glu Glu Lys Ile Ser Ile Phe Ser Leu Phe Ala Pro 
545                 550                 555                 560 


Phe Asp Phe Ala Val Trp Ala Cys Ile Ala Ala Ala Ile Pro Val Val 
                565                 570                 575     


Gly Val Leu Ile Phe Val Leu Asn Arg Ile Gln Ala Val Arg Ala Gln 
            580                 585                 590         


Ser Ala Ala Gln Pro Arg Pro Ser Ala Ser Ala Thr Leu His Ser Ala 
        595                 600                 605             


Ile Trp Ile Val Tyr Gly Ala Phe Val Gln Gln Gly Gly Glu Ser Ser 
    610                 615                 620                 


Val Asn Ser Met Ala Met Arg Ile Val Met Gly Ser Trp Trp Leu Phe 
625                 630                 635                 640 


Thr Leu Ile Val Cys Ser Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu 
                645                 650                 655     


Thr Val Ser Arg Met Asp Asn Pro Ile Arg Thr Phe Gln Asp Leu Ser 
            660                 665                 670         


Lys Gln Val Glu Met Ser Tyr Gly Thr Val Arg Asp Ser Ala Val Tyr 
        675                 680                 685             


Glu Tyr Phe Arg Ala Lys Gly Thr Asn Pro Leu Glu Gln Asp Ser Thr 
    690                 695                 700                 


Phe Ala Glu Leu Trp Arg Thr Ile Ser Lys Asn Gly Gly Ala Asp Asn 
705                 710                 715                 720 


Cys Val Ser Ser Pro Ser Glu Gly Ile Arg Lys Ala Lys Lys Gly Asn 
                725                 730                 735     


Tyr Ala Phe Leu Trp Asp Val Ala Val Val Glu Tyr Ala Ala Leu Thr 
            740                 745                 750         


Asp Asp Asp Cys Ser Val Thr Val Ile Gly Asn Ser Ile Ser Ser Lys 
        755                 760                 765             


Gly Tyr Gly Ile Ala Leu Gln His Gly Ser Pro Tyr Arg Asp Leu Phe 
    770                 775                 780                 


Ser Gln Arg Ile Leu Glu Leu Gln Asp Thr Gly Asp Leu Asp Val Leu 
785                 790                 795                 800 


Lys Gln Lys Trp Trp Pro His Met Gly Arg Cys Asp Leu Thr Ser His 
                805                 810                 815     


Ala Ser Ala Gln Ala Asp Gly Lys Ser Leu Lys Leu His Ser Phe Ala 
            820                 825                 830         


Gly Val Phe Cys Ile Leu Ala Ile Gly Leu Leu Leu Ala Cys Leu Val 
        835                 840                 845             


Ala Ala Leu Glu Leu Trp Trp Asn Ser Asn Arg Cys His Gln Glu Thr 
    850                 855                 860                 


Pro Lys Glu Asp Lys Glu Val Asn Leu Glu Gln Val His Arg Arg Met 
865                 870                 875                 880 


Asn Ser Leu Met Asp Glu Asp Ile Ala His Lys Gln Ile Ser Pro Ala 
                885                 890                 895     


Ser Ile Glu Leu Ser Ala Leu Glu Met Gly Gly Leu Ala Pro Thr Gln 
            900                 905                 910         


Thr Leu Glu Pro Thr Arg Glu Tyr Gln Asn Thr Gln Leu Ser Val Ser 
        915                 920                 925             


Thr Phe Leu Pro Glu Gln Ser Ser His Gly Thr Ser Arg Thr Leu Ser 
    930                 935                 940                 


Ser Gly Pro Ser Ser Asn Leu Pro Leu Pro Leu Ser Ser Ser Ala Thr 
945                 950                 955                 960 


Met Pro Ser Met Gln Cys Lys His Arg Ser Pro Asn Gly Gly Leu Phe 
                965                 970                 975     


Arg Gln Ser Pro Val Lys Thr Pro Ile Pro Met Ser Phe Gln Pro Val 
            980                 985                 990         


Pro Gly Gly Val Leu Pro Glu Ala  Leu Asp Thr Ser His  Gly Thr Ser 
        995                 1000                 1005             


Ile 
    


<210>  4306
<211>  541
<212>  PRT
<213>  Homo sapiens

<400>  4306

Met Pro Gly Leu Arg Arg Asp Arg Leu Leu Thr Leu Leu Leu Leu Gly 
1               5                   10                  15      


Ala Leu Leu Ser Ala Asp Leu Tyr Phe His Leu Trp Pro Gln Val Gln 
            20                  25                  30          


Arg Gln Leu Arg Pro Arg Glu Arg Pro Arg Gly Cys Pro Cys Thr Gly 
        35                  40                  45              


Arg Ala Ser Ser Leu Ala Arg Asp Ser Ala Ala Ala Ala Ser Asp Pro 
    50                  55                  60                  


Gly Thr Ile Val His Asn Phe Ser Arg Thr Glu Pro Arg Thr Glu Pro 
65                  70                  75                  80  


Ala Gly Gly Ser His Ser Gly Ser Ser Ser Lys Leu Gln Ala Leu Phe 
                85                  90                  95      


Ala His Pro Leu Tyr Asn Val Pro Glu Glu Pro Pro Leu Leu Gly Ala 
            100                 105                 110         


Glu Asp Ser Leu Leu Ala Ser Gln Glu Ala Leu Arg Tyr Tyr Arg Arg 
        115                 120                 125             


Lys Val Ala Arg Trp Asn Arg Arg His Lys Met Tyr Arg Glu Gln Met 
    130                 135                 140                 


Asn Leu Thr Ser Leu Asp Pro Pro Leu Gln Leu Arg Leu Glu Ala Ser 
145                 150                 155                 160 


Trp Val Gln Phe His Leu Gly Ile Asn Arg His Gly Leu Tyr Ser Arg 
                165                 170                 175     


Ser Ser Pro Val Val Ser Lys Leu Leu Gln Asp Met Arg His Phe Pro 
            180                 185                 190         


Thr Ile Ser Ala Asp Tyr Ser Gln Asp Glu Lys Ala Leu Leu Gly Ala 
        195                 200                 205             


Cys Asp Cys Thr Gln Ile Val Lys Pro Ser Gly Val His Leu Lys Leu 
    210                 215                 220                 


Val Leu Arg Phe Ser Asp Phe Gly Lys Ala Met Phe Lys Pro Met Arg 
225                 230                 235                 240 


Gln Gln Arg Asp Glu Glu Thr Pro Val Asp Phe Phe Tyr Phe Ile Asp 
                245                 250                 255     


Phe Gln Arg His Asn Ala Glu Ile Ala Ala Phe His Leu Asp Arg Ile 
            260                 265                 270         


Leu Asp Phe Arg Arg Val Pro Pro Thr Val Gly Arg Ile Val Asn Val 
        275                 280                 285             


Thr Lys Glu Ile Leu Glu Val Thr Lys Asn Glu Ile Leu Gln Ser Val 
    290                 295                 300                 


Phe Phe Val Ser Pro Ala Ser Asn Val Cys Phe Phe Ala Lys Cys Pro 
305                 310                 315                 320 


Tyr Met Cys Lys Thr Glu Tyr Ala Val Cys Gly Asn Pro His Leu Leu 
                325                 330                 335     


Glu Gly Ser Leu Ser Ala Phe Leu Pro Ser Leu Asn Leu Ala Pro Arg 
            340                 345                 350         


Leu Ser Val Pro Asn Pro Trp Ile Arg Ser Tyr Thr Leu Ala Gly Lys 
        355                 360                 365             


Glu Glu Trp Glu Val Asn Pro Leu Tyr Cys Asp Thr Val Lys Gln Ile 
    370                 375                 380                 


Tyr Pro Tyr Asn Asn Ser Gln Arg Leu Leu Asn Val Ile Asp Met Ala 
385                 390                 395                 400 


Ile Phe Asp Phe Leu Ile Gly Asn Met Asp Arg His His Tyr Glu Met 
                405                 410                 415     


Phe Thr Lys Phe Gly Asp Asp Gly Phe Leu Ile His Leu Asp Asn Ala 
            420                 425                 430         


Arg Gly Phe Gly Arg His Ser His Asp Glu Ile Ser Ile Leu Ser Pro 
        435                 440                 445             


Leu Ser Gln Cys Cys Met Ile Lys Lys Lys Thr Leu Leu His Leu Gln 
    450                 455                 460                 


Leu Leu Ala Gln Ala Asp Tyr Arg Leu Ser Asp Val Met Arg Glu Ser 
465                 470                 475                 480 


Leu Leu Glu Asp Gln Leu Ser Pro Val Leu Thr Glu Pro His Leu Leu 
                485                 490                 495     


Ala Leu Asp Arg Arg Leu Gln Thr Ile Leu Arg Thr Val Glu Gly Cys 
            500                 505                 510         


Ile Val Ala His Gly Gln Gln Ser Val Ile Val Asp Gly Pro Val Glu 
        515                 520                 525             


Gln Leu Ala Pro Asp Ser Gly Gln Ala Asn Leu Thr Ser 
    530                 535                 540     


<210>  4307
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  4307

Met Glu Gly Ala Pro Thr Val Arg Gln Val Met Asn Glu Gly Asp Ser 
1               5                   10                  15      


Ser Leu Ala Thr Asp Leu Gln Glu Asp Val Glu Glu Asn Pro Ser Pro 
            20                  25                  30          


Thr Val Glu Glu Asn Asn Val Val Val Lys Lys Gln Gly Pro Asn Leu 
        35                  40                  45              


His Asn Trp Ser Gly Asp Trp Ser Phe Trp Ile Ser Ser Ser Thr Tyr 
    50                  55                  60                  


Lys Asp Arg Asn Glu Glu Tyr Arg Arg Gln Phe Thr His Leu Pro Asp 
65                  70                  75                  80  


Thr Glu Arg Leu Ile Ala Asp Tyr Ala Cys Ala Leu Gln Arg Asp Ile 
                85                  90                  95      


Leu Leu Gln Gly Arg Leu Tyr Leu Ser Glu Asn Trp Leu Cys Phe Tyr 
            100                 105                 110         


Ser Asn Ile Phe Arg Trp Glu Thr Thr Ile Ser Ile Ala Leu Lys Asn 
        115                 120                 125             


Ile Thr Phe Met Thr Lys Glu Lys Thr Ala Arg Leu Ile Pro Asn Ala 
    130                 135                 140                 


Ile Gln Ile Val Thr Glu Ser Glu Lys Phe Phe Phe Thr Ser Phe Gly 
145                 150                 155                 160 


Ala Arg Asp Arg Ser Tyr Leu Ser Ile Phe Arg Leu Trp Gln Asn Val 
                165                 170                 175     


Leu Leu Asp Lys Ser Leu Thr Arg Gln Glu Phe Trp Gln Leu Leu Gln 
            180                 185                 190         


Gln Asn Tyr Gly Thr Glu Leu Gly Leu Asn Ala Glu Glu Met Glu Asn 
        195                 200                 205             


Leu Ser Leu Ser Ile Glu Asp Val Gln Pro Arg Ser Pro Gly Arg Ser 
    210                 215                 220                 


Ser Leu Asp Asp Ser Gly Glu Arg Asp Glu Lys Leu Ser Lys Ser Ile 
225                 230                 235                 240 


Ser Phe Thr Ser Glu Ser Ile Ser Arg Val Ser Glu Thr Glu Ser Phe 
                245                 250                 255     


Asp Gly Asn Ser Ser Lys Gly Gly Leu Gly Lys Glu Glu Ser Gln Asn 
            260                 265                 270         


Glu Lys Gln Thr Lys Lys Ser Leu Leu Pro Thr Leu Glu Lys Lys Leu 
        275                 280                 285             


Thr Arg Val Pro Ser Lys Ser Leu Asp Leu Asn Lys Asn Glu Tyr Leu 
    290                 295                 300                 


Ser Leu Asp Lys Ser Ser Thr Ser Asp Ser Val Asp Glu Glu Asn Val 
305                 310                 315                 320 


Pro Glu Lys Asp Leu His Gly Arg Leu Phe Ile Asn Arg Ile Phe His 
                325                 330                 335     


Ile Ser Ala Asp Arg Met Phe Glu Leu Leu Phe Thr Ser Ser Arg Phe 
            340                 345                 350         


Met Gln Lys Phe Ala Ser Ser Arg Asn Ile Ile Asp Val Val Ser Thr 
        355                 360                 365             


Pro Trp Thr Ala Glu Leu Gly Gly Asp Gln Leu Arg Thr Met Thr Tyr 
    370                 375                 380                 


Thr Ile Val Leu Asn Ser Pro Leu Thr Gly Lys Cys Thr Ala Ala Thr 
385                 390                 395                 400 


Glu Lys Gln Thr Leu Tyr Lys Glu Ser Arg Glu Ala Arg Phe Tyr Leu 
                405                 410                 415     


Val Asp Ser Glu Val Leu Thr His Asp Val Pro Tyr His Asp Tyr Phe 
            420                 425                 430         


Tyr Thr Val Asn Arg Tyr Cys Ile Ile Arg Ser Ser Lys Gln Lys Cys 
        435                 440                 445             


Arg Leu Arg Val Ser Thr Asp Leu Lys Tyr Arg Lys Gln Pro Trp Gly 
    450                 455                 460                 


Leu Val Lys Ser Leu Ile Glu Lys Asn Ser Trp Ser Ser Leu Glu Asp 
465                 470                 475                 480 


Tyr Phe Lys Gln Leu Glu Ser Asp Leu Leu Ile Glu Glu Ser Val Leu 
                485                 490                 495     


Asn Gln Ala Ile Glu Asp Pro Gly Lys Leu Thr Gly Leu Arg Arg Arg 
            500                 505                 510         


Arg Arg Thr Phe Asn Arg Thr Ala Glu Thr Val Pro Lys Leu Ser Ser 
        515                 520                 525             


Gln His Ser Ser Gly Asp Val Gly Leu Gly Ala Lys Gly Asp Ile Thr 
    530                 535                 540                 


Gly Lys Lys Lys Glu Met Glu Asn Tyr Asn Val Thr Leu Ile Val Val 
545                 550                 555                 560 


Met Ser Ile Phe Val Leu Leu Leu Val Leu Leu Asn Val Thr Leu Phe 
                565                 570                 575     


Leu Lys Leu Ser Lys Ile Glu His Ala Ala Gln Ser Phe Tyr Arg Leu 
            580                 585                 590         


Arg Leu Gln Glu Glu Lys Ser Leu Asn Leu Ala Ser Asp Met Val Ser 
        595                 600                 605             


Arg Ala Glu Thr Ile Gln Lys Asn Lys Asp Gln Ala His Arg Leu Lys 
    610                 615                 620                 


Gly Val Leu Arg Asp Ser Ile Val Met Leu Glu Gln Leu Lys Ser Ser 
625                 630                 635                 640 


Leu Ile Met Leu Gln Lys Thr Phe Asp Leu Leu Asn Lys Asn Lys Thr 
                645                 650                 655     


Gly Met Ala Val Glu Ser 
            660         


<210>  4308
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  4308

Met Asn Trp Ser His Ser Cys Ile Ser Phe Cys Trp Ile Tyr Phe Ala 
1               5                   10                  15      


Ala Ser Arg Leu Arg Ala Ala Glu Thr Ala Asp Gly Lys Tyr Ala Gln 
            20                  25                  30          


Lys Leu Phe Asn Asp Leu Phe Glu Asp Tyr Ser Asn Ala Leu Arg Pro 
        35                  40                  45              


Val Glu Asp Thr Asp Lys Val Leu Asn Val Thr Leu Gln Ile Thr Leu 
    50                  55                  60                  


Ser Gln Ile Lys Asp Met Asp Glu Arg Asn Gln Ile Leu Thr Ala Tyr 
65                  70                  75                  80  


Leu Trp Ile Arg Gln Ile Trp His Asp Ala Tyr Leu Thr Trp Asp Arg 
                85                  90                  95      


Asp Gln Tyr Asp Gly Leu Asp Ser Ile Arg Ile Pro Ser Asp Leu Val 
            100                 105                 110         


Trp Arg Pro Asp Ile Val Leu Tyr Asn Lys Ala Asp Asp Glu Ser Ser 
        115                 120                 125             


Glu Pro Val Asn Thr Asn Val Val Leu Arg Tyr Asp Gly Leu Ile Thr 
    130                 135                 140                 


Trp Asp Ala Pro Ala Ile Thr Lys Ser Ser Cys Val Val Asp Val Thr 
145                 150                 155                 160 


Tyr Phe Pro Phe Asp Asn Gln Gln Cys Asn Leu Thr Phe Gly Ser Trp 
                165                 170                 175     


Thr Tyr Asn Gly Asn Gln Val Asp Ile Phe Asn Ala Leu Asp Ser Gly 
            180                 185                 190         


Asp Leu Ser Asp Phe Ile Glu Asp Val Glu Trp Glu Val His Gly Met 
        195                 200                 205             


Pro Ala Val Lys Asn Val Ile Ser Tyr Gly Cys Cys Ser Glu Pro Tyr 
    210                 215                 220                 


Pro Asp Val Thr Phe Thr Leu Leu Leu Lys Arg Arg Ser Ser Phe Tyr 
225                 230                 235                 240 


Ile Val Asn Leu Leu Ile Pro Cys Val Leu Ile Ser Phe Leu Ala Pro 
                245                 250                 255     


Leu Ser Phe Tyr Leu Pro Ala Ala Ser Gly Glu Lys Val Ser Leu Gly 
            260                 265                 270         


Val Thr Ile Leu Leu Ala Met Thr Val Phe Gln Leu Met Val Ala Glu 
        275                 280                 285             


Ile Met Pro Ala Ser Glu Asn Val Pro Leu Ile Gly Lys Tyr Tyr Ile 
    290                 295                 300                 


Ala Thr Met Ala Leu Ile Thr Ala Ser Thr Ala Leu Thr Ile Met Val 
305                 310                 315                 320 


Met Asn Ile His Phe Cys Gly Ala Glu Ala Arg Pro Val Pro His Trp 
                325                 330                 335     


Ala Arg Val Val Ile Leu Lys Tyr Met Ser Arg Val Leu Phe Val Tyr 
            340                 345                 350         


Asp Val Gly Glu Ser Cys Leu Ser Pro His His Ser Arg Glu Arg Asp 
        355                 360                 365             


His Leu Thr Lys Val Tyr Ser Lys Leu Pro Glu Ser Asn Leu Lys Ala 
    370                 375                 380                 


Ala Arg Asn Lys Asp Leu Ser Arg Lys Lys Asp Met Asn Lys Arg Leu 
385                 390                 395                 400 


Lys Asn Asp Leu Gly Cys Gln Gly Lys Asn Pro Gln Glu Ala Glu Ser 
                405                 410                 415     


Tyr Cys Ala Gln Tyr Lys Val Leu Thr Arg Asn Ile Glu Tyr Ile Ala 
            420                 425                 430         


Lys Cys Leu Lys Asp His Lys Ala Thr Asn Ser Lys Gly Ser Glu Trp 
        435                 440                 445             


Lys Lys Val Ala Lys Val Ile Asp Arg Phe Phe Met Trp Ile Phe Phe 
    450                 455                 460                 


Ile Met Val Phe Val Met Thr Ile Leu Ile Ile Ala Arg Ala Asp 
465                 470                 475                 


<210>  4309
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  4309

Met Gln Glu Pro Leu Leu Gly Ala Glu Gly Pro Asp Tyr Asp Thr Phe 
1               5                   10                  15      


Pro Glu Lys Pro Pro Pro Ser Pro Gly Asp Arg Ala Arg Val Gly Thr 
            20                  25                  30          


Leu Gln Asn Lys Arg Val Phe Leu Ala Thr Phe Ala Ala Val Leu Gly 
        35                  40                  45              


Asn Phe Ser Phe Gly Tyr Ala Leu Val Tyr Thr Ser Pro Val Ile Pro 
    50                  55                  60                  


Ala Leu Glu Arg Ser Leu Asp Pro Asp Leu His Leu Thr Lys Ser Gln 
65                  70                  75                  80  


Ala Ser Trp Phe Gly Ser Val Phe Thr Leu Gly Ala Ala Ala Gly Gly 
                85                  90                  95      


Leu Ser Ala Met Ile Leu Asn Asp Leu Leu Gly Arg Lys Leu Ser Ile 
            100                 105                 110         


Met Phe Ser Ala Val Pro Ser Ala Ala Gly Tyr Ala Leu Met Ala Gly 
        115                 120                 125             


Ala His Gly Leu Trp Met Leu Leu Leu Gly Arg Thr Leu Thr Gly Phe 
    130                 135                 140                 


Ala Gly Gly Leu Thr Ala Ala Cys Ile Pro Val Tyr Val Ser Glu Ile 
145                 150                 155                 160 


Ala Pro Pro Gly Val Arg Gly Ala Leu Gly Ala Thr Pro Gln Leu Met 
                165                 170                 175     


Ala Val Phe Gly Ser Leu Ser Leu Tyr Ala Leu Gly Leu Leu Leu Pro 
            180                 185                 190         


Trp Arg Trp Leu Ala Val Ala Gly Glu Ala Pro Val Leu Ile Met Ile 
        195                 200                 205             


Leu Leu Leu Ser Phe Met Pro Asn Ser Pro Arg Phe Leu Leu Ser Arg 
    210                 215                 220                 


Gly Arg Asp Glu Glu Ala Leu Arg Ala Leu Ala Trp Leu Arg Gly Thr 
225                 230                 235                 240 


Asp Val Asp Val His Trp Glu Phe Glu Gln Ile Gln Asp Asn Val Arg 
                245                 250                 255     


Arg Gln Ser Ser Arg Val Ser Trp Ala Glu Ala Arg Ala Pro His Val 
            260                 265                 270         


Cys Arg Pro Ile Thr Val Ala Leu Leu Met Arg Leu Leu Gln Gln Leu 
        275                 280                 285             


Thr Gly Ile Thr Pro Ile Leu Val Tyr Leu Gln Ser Ile Phe Asp Ser 
    290                 295                 300                 


Thr Ala Val Leu Leu Pro Pro Lys Asp Asp Ala Ala Ile Val Gly Ala 
305                 310                 315                 320 


Val Arg Leu Leu Ser Val Leu Ile Ala Ala Leu Thr Met Asp Leu Ala 
                325                 330                 335     


Gly Arg Lys Val Leu Leu Phe Val Ser Ala Ala Ile Met Phe Ala Ala 
            340                 345                 350         


Asn Leu Thr Leu Gly Leu Tyr Ile His Phe Gly Pro Arg Pro Leu Ser 
        355                 360                 365             


Pro Asn Ser Thr Ala Gly Leu Glu Ser Glu Ser Trp Gly Asp Leu Ala 
    370                 375                 380                 


Gln Pro Leu Ala Ala Pro Ala Gly Tyr Leu Thr Leu Val Pro Leu Leu 
385                 390                 395                 400 


Ala Thr Met Leu Phe Ile Met Gly Tyr Ala Val Gly Trp Gly Pro Ile 
                405                 410                 415     


Thr Trp Leu Leu Met Ser Glu Val Leu Pro Leu Arg Ala Arg Gly Val 
            420                 425                 430         


Ala Ser Gly Leu Cys Val Leu Ala Ser Trp Leu Thr Ala Phe Val Leu 
        435                 440                 445             


Thr Lys Ser Phe Leu Pro Val Val Ser Thr Phe Gly Leu Gln Val Pro 
    450                 455                 460                 


Phe Phe Phe Phe Ala Ala Ile Cys Leu Val Ser Leu Val Phe Thr Gly 
465                 470                 475                 480 


Cys Cys Val Pro Glu Thr Lys Gly Arg Ser Leu Glu Gln Ile Glu Ser 
                485                 490                 495     


Phe Phe Arg Thr Gly Arg Arg Ser Phe Leu Arg 
            500                 505         


<210>  4310
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  4310

Met Ser Ser Ser Gly Gly Ala Pro Gly Ala Ser Ala Ser Ser Ala Pro 
1               5                   10                  15      


Pro Ala Gln Glu Glu Gly Met Thr Trp Trp Tyr Arg Trp Leu Cys Arg 
            20                  25                  30          


Leu Ser Gly Val Leu Gly Ala Val Ser Cys Ala Ile Ser Gly Leu Phe 
        35                  40                  45              


Asn Cys Ile Thr Ile His Pro Leu Asn Ile Ala Ala Gly Val Trp Met 
    50                  55                  60                  


Ile Met Asn Ala Phe Ile Leu Leu Leu Cys Glu Ala Pro Phe Cys Cys 
65                  70                  75                  80  


Gln Phe Ile Glu Phe Ala Asn Thr Val Ala Glu Lys Val Asp Arg Leu 
                85                  90                  95      


Arg Ser Trp Gln Lys Ala Val Phe Tyr Cys Gly Met Ala Val Val Pro 
            100                 105                 110         


Ile Val Ile Ser Leu Thr Leu Thr Thr Leu Leu Gly Asn Ala Ile Ala 
        115                 120                 125             


Phe Ala Thr Gly Val Leu Tyr Gly Leu Ser Ala Leu Gly Lys Lys Gly 
    130                 135                 140                 


Asp Ala Ile Ser Tyr Ala Arg Ile Gln Gln Gln Arg Gln Gln Ala Asp 
145                 150                 155                 160 


Glu Glu Lys Leu Ala Glu Thr Leu Glu Gly Glu Leu 
                165                 170         


<210>  4311
<211>  779
<212>  PRT
<213>  Homo sapiens

<400>  4311

Met Thr Pro Glu Phe Asp Glu Glu Val Val Phe Glu Asn Ser Pro Leu 
1               5                   10                  15      


Tyr Gln Tyr Leu Gln Asp Leu Gly His Thr Asp Phe Glu Ile Cys Ser 
            20                  25                  30          


Ser Leu Ser Pro Lys Thr Glu Lys Cys Thr Thr Glu Gly Gln Gln Lys 
        35                  40                  45              


Pro Pro Thr Arg Val Leu Pro Lys Gln Gly Ile Leu Leu Lys Val Ala 
    50                  55                  60                  


Glu Thr Ile Lys Ser Trp Ile Phe Phe Ser Gln Cys Asn Lys Lys Asp 
65                  70                  75                  80  


Asp Leu Leu His Lys Leu Asp Ile Gly Phe Arg Leu Asp Ser Leu His 
                85                  90                  95      


Thr Ile Leu Gln Gln Glu Val Leu Leu Gln Glu Asp Val Glu Leu Ile 
            100                 105                 110         


Glu Leu Leu Asp Pro Ser Ile Leu Ser Ala Gly Gln Ser Gln Gln Gln 
        115                 120                 125             


Glu Asn Gly His Leu Pro Thr Leu Cys Ser Leu Ala Thr Pro Asn Ile 
    130                 135                 140                 


Trp Asp Leu Ser Met Leu Phe Ala Phe Ile Ser Leu Leu Val Met Leu 
145                 150                 155                 160 


Pro Thr Trp Trp Ile Val Ser Ser Trp Leu Val Trp Gly Val Ile Leu 
                165                 170                 175     


Phe Val Tyr Leu Val Ile Arg Ala Leu Arg Leu Trp Arg Thr Ala Lys 
            180                 185                 190         


Leu Gln Val Thr Leu Lys Lys Tyr Ser Val His Leu Glu Asp Met Ala 
        195                 200                 205             


Thr Asn Ser Arg Ala Phe Thr Asn Leu Val Arg Lys Ala Leu Arg Leu 
    210                 215                 220                 


Ile Gln Glu Thr Glu Val Ile Ser Arg Gly Phe Thr Leu Val Ser Ala 
225                 230                 235                 240 


Ala Cys Pro Phe Asn Lys Ala Gly Gln His Pro Ser Gln His Leu Ile 
                245                 250                 255     


Gly Leu Arg Lys Ala Val Tyr Arg Thr Leu Arg Ala Asn Phe Gln Ala 
            260                 265                 270         


Ala Arg Leu Ala Thr Leu Tyr Met Leu Lys Asn Tyr Pro Leu Asn Ser 
        275                 280                 285             


Glu Ser Asp Asn Val Thr Asn Tyr Ile Cys Val Val Pro Phe Lys Glu 
    290                 295                 300                 


Leu Gly Leu Gly Leu Ser Glu Glu Gln Ile Ser Glu Glu Glu Ala His 
305                 310                 315                 320 


Asn Phe Thr Asp Gly Phe Ser Leu Pro Ala Leu Lys Val Leu Phe Gln 
                325                 330                 335     


Leu Trp Val Ala Gln Ser Ser Glu Phe Phe Arg Arg Leu Ala Leu Leu 
            340                 345                 350         


Leu Ser Thr Ala Asn Ser Pro Pro Gly Pro Leu Leu Thr Pro Ala Leu 
        355                 360                 365             


Leu Pro His Arg Ile Leu Ser Asp Val Thr Gln Gly Leu Pro His Ala 
    370                 375                 380                 


His Ser Ala Cys Leu Glu Glu Leu Lys Arg Ser Tyr Glu Phe Tyr Arg 
385                 390                 395                 400 


Tyr Phe Glu Thr Gln His Gln Ser Val Pro Gln Cys Leu Ser Lys Thr 
                405                 410                 415     


Gln Gln Lys Ser Arg Glu Leu Asn Asn Val His Thr Ala Val Arg Ser 
            420                 425                 430         


Leu Gln Leu His Leu Lys Ala Leu Leu Asn Glu Val Ile Ile Leu Glu 
        435                 440                 445             


Asp Glu Leu Glu Lys Leu Val Cys Thr Lys Glu Thr Gln Glu Leu Val 
    450                 455                 460                 


Ser Glu Ala Tyr Pro Ile Leu Glu Gln Lys Leu Lys Leu Ile Gln Pro 
465                 470                 475                 480 


His Val Gln Ala Ser Asn Asn Cys Trp Glu Glu Ala Ile Ser Gln Val 
                485                 490                 495     


Asp Lys Leu Leu Arg Arg Asn Thr Asp Lys Lys Gly Lys Pro Glu Ile 
            500                 505                 510         


Ala Cys Glu Asn Pro His Cys Thr Val Val Pro Leu Lys Gln Pro Thr 
        515                 520                 525             


Leu His Ile Ala Asp Lys Asp Pro Ile Pro Glu Glu Gln Glu Leu Glu 
    530                 535                 540                 


Ala Tyr Val Asp Asp Ile Asp Ile Asp Ser Asp Phe Arg Lys Asp Asp 
545                 550                 555                 560 


Phe Tyr Tyr Leu Ser Gln Glu Asp Lys Glu Arg Gln Lys Arg Glu His 
                565                 570                 575     


Glu Glu Ser Lys Arg Val Leu Gln Glu Leu Lys Ser Val Leu Gly Phe 
            580                 585                 590         


Lys Ala Ser Glu Ala Glu Arg Gln Lys Trp Lys Gln Leu Leu Phe Ser 
        595                 600                 605             


Asp His Ala Val Leu Lys Ser Leu Ser Pro Val Asp Pro Val Glu Pro 
    610                 615                 620                 


Ile Ser Asn Ser Glu Pro Ser Met Asn Ser Asp Met Gly Lys Val Ser 
625                 630                 635                 640 


Lys Asn Asp Thr Glu Glu Glu Ser Asn Lys Ser Ala Thr Thr Asp Asn 
                645                 650                 655     


Glu Ile Ser Arg Thr Glu Tyr Leu Cys Glu Asn Ser Leu Glu Gly Lys 
            660                 665                 670         


Asn Lys Asp Asn Ser Ser Asn Glu Val Phe Pro Gln Gly Ala Glu Glu 
        675                 680                 685             


Arg Met Cys Tyr Gln Cys Glu Ser Glu Asp Glu Pro Gln Ala Asp Gly 
    690                 695                 700                 


Ser Gly Leu Thr Thr Ala Pro Pro Thr Pro Arg Asp Ser Leu Gln Pro 
705                 710                 715                 720 


Ser Ile Lys Gln Arg Leu Ala Arg Leu Gln Leu Ser Pro Asp Phe Thr 
                725                 730                 735     


Phe Thr Ala Gly Leu Ala Ala Glu Val Ala Ala Arg Ser Leu Ser Phe 
            740                 745                 750         


Thr Thr Met Gln Glu Gln Thr Phe Gly Gly Glu Glu Glu Glu Gln Ile 
        755                 760                 765             


Ile Glu Glu Asn Lys Asn Glu Ile Glu Glu Lys 
    770                 775                 


<210>  4312
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  4312

Met Ala Gly Gln Gly Leu Pro Leu His Val Ala Thr Leu Leu Thr Gly 
1               5                   10                  15      


Leu Leu Glu Cys Leu Gly Phe Ala Gly Val Leu Phe Gly Trp Pro Ser 
            20                  25                  30          


Leu Val Phe Val Phe Lys Asn Glu Asp Tyr Phe Lys Asp Leu Cys Gly 
        35                  40                  45              


Pro Asp Ala Gly Pro Ile Gly Asn Ala Thr Gly Gln Ala Asp Cys Lys 
    50                  55                  60                  


Ala Gln Asp Glu Arg Phe Ser Leu Ile Phe Thr Leu Gly Ser Phe Met 
65                  70                  75                  80  


Asn Asn Phe Met Thr Phe Pro Thr Gly Tyr Ile Phe Asp Arg Phe Lys 
                85                  90                  95      


Thr Thr Val Ala Arg Leu Ile Ala Ile Phe Phe Tyr Thr Thr Ala Thr 
            100                 105                 110         


Leu Ile Ile Ala Phe Thr Ser Ala Gly Ser Ala Val Leu Leu Phe Leu 
        115                 120                 125             


Ala Met Pro Met Leu Thr Ile Gly Gly Ile Leu Phe Leu Ile Thr Asn 
    130                 135                 140                 


Leu Gln Ile Gly Asn Leu Phe Gly Gln His Arg Ser Thr Ile Ile Thr 
145                 150                 155                 160 


Leu Tyr Asn Gly Ala Phe Asp Ser Ser Ser Ala Val Phe Leu Ile Ile 
                165                 170                 175     


Lys Leu Leu Tyr Glu Lys Gly Ile Ser Leu Arg Ala Ser Phe Ile Phe 
            180                 185                 190         


Ile Ser Val Cys Ser Thr Trp His Val Ala Arg Thr Phe Leu Leu Met 
        195                 200                 205             


Pro Arg Gly His Ile Pro Tyr Pro Leu Pro Pro Asn Tyr Ser Tyr Gly 
    210                 215                 220                 


Leu Cys Pro Gly Asn Gly Thr Thr Lys Glu Glu Lys Glu Thr Ala Glu 
225                 230                 235                 240 


His Glu Asn Arg Glu Leu Gln Ser Lys Glu Phe Leu Ser Ala Lys Glu 
                245                 250                 255     


Glu Thr Pro Gly Ala Gly Gln Lys Gln Glu Leu Arg Ser Phe Trp Ser 
            260                 265                 270         


Tyr Ala Phe Ser Arg Arg Phe Ala Trp His Leu Val Trp Leu Ser Val 
        275                 280                 285             


Ile Gln Leu Trp His Tyr Leu Phe Ile Gly Thr Leu Asn Ser Leu Leu 
    290                 295                 300                 


Thr Asn Met Ala Gly Gly Asp Met Ala Arg Val Ser Thr Tyr Thr Asn 
305                 310                 315                 320 


Ala Phe Ala Phe Thr Gln Phe Gly Val Leu Cys Ala Pro Trp Asn Gly 
                325                 330                 335     


Leu Leu Met Asp Arg Leu Lys Gln Lys Tyr Gln Lys Glu Ala Arg Lys 
            340                 345                 350         


Thr Gly Ser Ser Thr Leu Ala Val Ala Leu Cys Ser Thr Val Pro Ser 
        355                 360                 365             


Leu Ala Leu Thr Ser Leu Leu Cys Leu Gly Phe Ala Leu Cys Ala Ser 
    370                 375                 380                 


Val Pro Ile Leu Pro Leu Gln Tyr Leu Thr Phe Ile Leu Gln Val Ile 
385                 390                 395                 400 


Ser Arg Ser Phe Leu Tyr Gly Ser Asn Ala Ala Phe Leu Thr Leu Ala 
                405                 410                 415     


Phe Pro Ser Glu His Phe Gly Lys Leu Phe Gly Leu Val Met Ala Leu 
            420                 425                 430         


Ser Ala Val Val Ser Leu Leu Gln Phe Pro Ile Phe Thr Leu Ile Lys 
        435                 440                 445             


Gly Ser Leu Gln Asn Asp Pro Phe Tyr Val Asn Val Met Phe Met Leu 
    450                 455                 460                 


Ala Ile Leu Leu Thr Phe Phe His Pro Phe Leu Val Tyr Arg Glu Cys 
465                 470                 475                 480 


Arg Thr Trp Lys Glu Ser Pro Ser Ala Ile Ala 
                485                 490     


<210>  4313
<211>  707
<212>  PRT
<213>  Homo sapiens

<400>  4313

Met Ala Ala Ala Val Ala Ala Ala Gly Arg Leu Gly Trp Leu Phe Ala 
1               5                   10                  15      


Ala Leu Cys Leu Gly Asn Ala Ala Gly Glu Ala Ala Pro Gly Pro Arg 
            20                  25                  30          


Val Leu Gly Phe Cys Leu Glu Glu Asp Gly Ala Ala Gly Ala Gly Trp 
        35                  40                  45              


Val Arg Gly Gly Ala Ala Arg Asp Thr Pro Asp Ala Thr Phe Leu Leu 
    50                  55                  60                  


Arg Leu Phe Gly Pro Gly Phe Ala Asn Ser Ser Trp Ser Trp Val Ala 
65                  70                  75                  80  


Pro Glu Gly Ala Gly Cys Arg Glu Glu Ala Ala Ser Pro Ala Gly Glu 
                85                  90                  95      


Trp Arg Ala Leu Leu Arg Leu Arg Leu Arg Ala Glu Ala Val Arg Pro 
            100                 105                 110         


His Ser Ala Leu Leu Ala Val Arg Val Glu Pro Gly Gly Gly Ala Ala 
        115                 120                 125             


Glu Glu Ala Ala Pro Pro Trp Ala Leu Gly Leu Gly Ala Ala Gly Leu 
    130                 135                 140                 


Leu Ala Leu Ala Ala Leu Ala Arg Gly Leu Gln Leu Ser Ala Leu Ala 
145                 150                 155                 160 


Leu Ala Pro Ala Glu Val Gln Val Leu Arg Glu Ser Gly Ser Glu Ala 
                165                 170                 175     


Glu Arg Ala Ala Ala Arg Arg Leu Glu Pro Ala Arg Arg Trp Ala Gly 
            180                 185                 190         


Cys Ala Leu Gly Ala Leu Leu Leu Leu Ala Ser Leu Ala Gln Ala Ala 
        195                 200                 205             


Leu Ala Val Leu Leu Tyr Arg Ala Ala Gly Gln Arg Ala Val Pro Ala 
    210                 215                 220                 


Val Leu Gly Ser Ala Gly Leu Val Phe Leu Val Gly Glu Val Val Pro 
225                 230                 235                 240 


Ala Ala Val Ser Gly Arg Trp Thr Leu Ala Leu Ala Pro Arg Ala Leu 
                245                 250                 255     


Gly Leu Ser Arg Leu Ala Val Leu Leu Thr Leu Pro Val Ala Leu Pro 
            260                 265                 270         


Val Gly Gln Leu Leu Glu Leu Ala Ala Arg Pro Gly Arg Leu Arg Glu 
        275                 280                 285             


Arg Val Leu Glu Leu Ala Arg Gly Gly Gly Asp Pro Tyr Ser Asp Leu 
    290                 295                 300                 


Ser Lys Gly Val Leu Arg Cys Arg Thr Val Glu Asp Val Leu Thr Pro 
305                 310                 315                 320 


Leu Glu Asp Cys Phe Met Leu Asp Ala Ser Thr Val Leu Asp Phe Gly 
                325                 330                 335     


Val Leu Ala Ser Ile Met Gln Ser Gly His Thr Arg Ile Pro Val Tyr 
            340                 345                 350         


Glu Glu Glu Arg Ser Asn Ile Val Asp Met Leu Tyr Leu Lys Asp Leu 
        355                 360                 365             


Ala Phe Val Asp Pro Glu Asp Cys Thr Pro Leu Ser Thr Ile Thr Arg 
    370                 375                 380                 


Phe Tyr Asn His Pro Leu His Phe Val Phe Asn Asp Thr Lys Leu Asp 
385                 390                 395                 400 


Ala Val Leu Glu Glu Phe Lys Arg Gly Lys Ser His Leu Ala Ile Val 
                405                 410                 415     


Gln Lys Val Asn Asn Glu Gly Glu Gly Asp Pro Phe Tyr Glu Val Leu 
            420                 425                 430         


Gly Leu Val Thr Leu Glu Asp Val Ile Glu Glu Ile Ile Arg Ser Glu 
        435                 440                 445             


Ile Leu Asp Glu Ser Glu Asp Tyr Arg Asp Thr Val Val Lys Arg Lys 
    450                 455                 460                 


Pro Ala Ser Leu Met Ala Pro Leu Lys Arg Lys Glu Glu Phe Ser Leu 
465                 470                 475                 480 


Phe Lys Val Ser Asp Asp Glu Tyr Lys Val Thr Ile Ser Pro Gln Leu 
                485                 490                 495     


Leu Leu Ala Thr Gln Arg Phe Leu Ser Arg Glu Val Asp Val Phe Ser 
            500                 505                 510         


Pro Leu Arg Ile Ser Glu Lys Val Leu Leu His Leu Leu Lys His Pro 
        515                 520                 525             


Ser Val Asn Gln Glu Val Arg Phe Asp Glu Ser Asn Arg Leu Ala Thr 
    530                 535                 540                 


His His Tyr Leu Tyr Gln Arg Ser Gln Pro Val Asp Tyr Phe Ile Leu 
545                 550                 555                 560 


Ile Leu Gln Gly Arg Val Glu Val Glu Ile Gly Lys Glu Gly Leu Lys 
                565                 570                 575     


Phe Glu Asn Gly Ala Phe Thr Tyr Tyr Gly Val Ser Ala Leu Thr Val 
            580                 585                 590         


Pro Ser Ser Val His Gln Ser Pro Val Ser Ser Leu Gln Pro Ile Arg 
        595                 600                 605             


His Asp Leu Gln Pro Asp Pro Gly Asp Gly Thr His Ser Ser Ala Tyr 
    610                 615                 620                 


Cys Pro Asp Tyr Thr Val Arg Ala Leu Ser Asp Leu Gln Leu Ile Lys 
625                 630                 635                 640 


Val Thr Arg Leu Gln Tyr Leu Asn Ala Leu Leu Ala Thr Arg Ala Gln 
                645                 650                 655     


Asn Leu Pro Gln Ser Pro Glu Asn Thr Asp Leu Gln Val Ile Pro Gly 
            660                 665                 670         


Ser Gln Thr Arg Leu Leu Gly Glu Lys Thr Thr Thr Ala Ala Gly Ser 
        675                 680                 685             


Ser His Ser Arg Pro Gly Val Pro Val Glu Gly Ser Pro Gly Arg Asn 
    690                 695                 700                 


Pro Gly Val 
705         


<210>  4314
<211>  409
<212>  PRT
<213>  Homo sapiens

<400>  4314

Met Ser Ser Leu Arg Ala Arg Leu Pro Ala Thr Arg Arg Arg Val Ala 
1               5                   10                  15      


Gln Pro Phe Ala Arg Pro Ala Ser Pro Ser Leu Val Pro Arg Ser Gly 
            20                  25                  30          


Ser Ala Met Glu Ser Asn Lys Asp Glu Ala Glu Arg Cys Ile Ser Ile 
        35                  40                  45              


Ala Leu Lys Ala Ile Gln Ser Asn Gln Pro Asp Arg Ala Leu Arg Phe 
    50                  55                  60                  


Leu Glu Lys Ala Gln Arg Leu Tyr Pro Thr Pro Arg Val Arg Ala Leu 
65                  70                  75                  80  


Ile Glu Ser Leu Asn Gln Lys Pro Gln Thr Ala Gly Asp Gln Pro Pro 
                85                  90                  95      


Pro Thr Asp Thr Thr His Ala Thr His Arg Lys Ala Gly Gly Thr Asp 
            100                 105                 110         


Ala Pro Ser Ala Asn Gly Glu Ala Gly Gly Glu Ser Thr Lys Gly Tyr 
        115                 120                 125             


Thr Ala Glu Gln Val Ala Ala Val Lys Arg Val Lys Gln Cys Lys Asp 
    130                 135                 140                 


Tyr Tyr Glu Ile Leu Gly Val Ser Arg Gly Ala Ser Asp Glu Asp Leu 
145                 150                 155                 160 


Lys Lys Ala Tyr Arg Arg Leu Ala Leu Lys Phe His Pro Asp Lys Asn 
                165                 170                 175     


His Ala Pro Gly Ala Thr Glu Ala Phe Lys Ala Ile Gly Thr Ala Tyr 
            180                 185                 190         


Ala Val Leu Ser Asn Pro Glu Lys Arg Lys Gln Tyr Asp Gln Phe Gly 
        195                 200                 205             


Asp Asp Lys Ser Gln Ala Ala Arg His Gly His Gly His Gly Asp Phe 
    210                 215                 220                 


His Arg Gly Phe Glu Ala Asp Ile Ser Pro Glu Asp Leu Phe Asn Met 
225                 230                 235                 240 


Phe Phe Gly Gly Gly Phe Pro Ser Ser Asn Val His Val Tyr Ser Asn 
                245                 250                 255     


Gly Arg Met Arg Tyr Thr Tyr Gln Gln Arg Gln Asp Arg Arg Asp Asn 
            260                 265                 270         


Gln Gly Asp Gly Gly Leu Gly Val Phe Val Gln Leu Met Pro Ile Leu 
        275                 280                 285             


Ile Leu Ile Leu Val Ser Ala Leu Ser Gln Leu Met Val Ser Ser Pro 
    290                 295                 300                 


Pro Tyr Ser Leu Ser Pro Arg Pro Ser Val Gly His Ile His Arg Arg 
305                 310                 315                 320 


Val Thr Asp His Leu Gly Val Val Tyr Tyr Val Gly Asp Thr Phe Ser 
                325                 330                 335     


Glu Glu Tyr Thr Gly Ser Ser Leu Lys Thr Val Glu Arg Asn Val Glu 
            340                 345                 350         


Asp Asp Tyr Ile Ala Asn Leu Arg Asn Asn Cys Trp Lys Glu Lys Gln 
        355                 360                 365             


Gln Lys Glu Gly Leu Leu Tyr Arg Ala Arg Tyr Phe Gly Asp Thr Asp 
    370                 375                 380                 


Met Tyr His Arg Ala Gln Lys Met Gly Thr Pro Ser Cys Ser Arg Leu 
385                 390                 395                 400 


Ser Glu Val Gln Ala Ser Leu His Gly 
                405                 


<210>  4315
<211>  1214
<212>  PRT
<213>  Homo sapiens

<400>  4315

Met Val Val Pro Glu Lys Glu Gln Ser Trp Ile Pro Lys Ile Phe Lys 
1               5                   10                  15      


Lys Lys Thr Cys Thr Thr Phe Ile Val Asp Ser Thr Asp Pro Gly Gly 
            20                  25                  30          


Thr Leu Cys Gln Cys Gly Arg Pro Arg Thr Ala His Pro Ala Val Ala 
        35                  40                  45              


Met Glu Asp Ala Phe Gly Ala Ala Val Val Thr Val Trp Asp Ser Asp 
    50                  55                  60                  


Ala His Thr Thr Glu Lys Pro Thr Asp Ala Tyr Gly Glu Leu Asp Phe 
65                  70                  75                  80  


Thr Gly Ala Gly Arg Lys His Ser Asn Phe Leu Arg Leu Ser Asp Arg 
                85                  90                  95      


Thr Asp Pro Ala Ala Val Tyr Ser Leu Val Thr Arg Thr Trp Gly Phe 
            100                 105                 110         


Arg Ala Pro Asn Leu Val Val Ser Val Leu Gly Gly Ser Gly Gly Pro 
        115                 120                 125             


Val Leu Gln Thr Trp Leu Gln Asp Leu Leu Arg Arg Gly Leu Val Arg 
    130                 135                 140                 


Ala Ala Gln Ser Thr Gly Ala Trp Ile Val Thr Gly Gly Leu His Thr 
145                 150                 155                 160 


Gly Ile Gly Arg His Val Gly Val Ala Val Arg Asp His Gln Met Ala 
                165                 170                 175     


Ser Thr Gly Gly Thr Lys Val Val Ala Met Gly Val Ala Pro Trp Gly 
            180                 185                 190         


Val Val Arg Asn Arg Asp Thr Leu Ile Asn Pro Lys Gly Ser Phe Pro 
        195                 200                 205             


Ala Arg Tyr Arg Trp Arg Gly Asp Pro Glu Asp Gly Val Gln Phe Pro 
    210                 215                 220                 


Leu Asp Tyr Asn Tyr Ser Ala Phe Phe Leu Val Asp Asp Gly Thr His 
225                 230                 235                 240 


Gly Cys Leu Gly Gly Glu Asn Arg Phe Arg Leu Arg Leu Glu Ser Tyr 
                245                 250                 255     


Ile Ser Gln Gln Lys Thr Gly Val Gly Gly Thr Gly Ile Asp Ile Pro 
            260                 265                 270         


Val Leu Leu Leu Leu Ile Asp Gly Asp Glu Lys Met Leu Thr Arg Ile 
        275                 280                 285             


Glu Asn Ala Thr Gln Ala Gln Leu Pro Cys Leu Leu Val Ala Gly Ser 
    290                 295                 300                 


Gly Gly Ala Ala Asp Cys Leu Ala Glu Thr Leu Glu Asp Thr Leu Ala 
305                 310                 315                 320 


Pro Gly Ser Gly Gly Ala Arg Gln Gly Glu Ala Arg Asp Arg Ile Arg 
                325                 330                 335     


Arg Phe Phe Pro Lys Gly Asp Leu Glu Val Leu Gln Ala Gln Val Glu 
            340                 345                 350         


Arg Ile Met Thr Arg Lys Glu Leu Leu Thr Val Tyr Ser Ser Glu Asp 
        355                 360                 365             


Gly Ser Glu Glu Phe Glu Thr Ile Val Leu Lys Ala Leu Val Lys Ala 
    370                 375                 380                 


Cys Gly Ser Ser Glu Ala Ser Ala Tyr Leu Asp Glu Leu Arg Leu Ala 
385                 390                 395                 400 


Val Ala Trp Asn Arg Val Asp Ile Ala Gln Ser Glu Leu Phe Arg Gly 
                405                 410                 415     


Asp Ile Gln Trp Arg Ser Phe His Leu Glu Ala Ser Leu Met Asp Ala 
            420                 425                 430         


Leu Leu Asn Asp Arg Pro Glu Phe Val Arg Leu Leu Ile Ser His Gly 
        435                 440                 445             


Leu Ser Leu Gly His Phe Leu Thr Pro Met Arg Leu Ala Gln Leu Tyr 
    450                 455                 460                 


Ser Ala Ala Pro Ser Asn Ser Leu Ile Arg Asn Leu Leu Asp Gln Ala 
465                 470                 475                 480 


Ser His Ser Ala Gly Thr Lys Ala Pro Ala Leu Lys Gly Gly Ala Ala 
                485                 490                 495     


Glu Leu Arg Pro Pro Asp Val Gly His Val Leu Arg Met Leu Leu Gly 
            500                 505                 510         


Lys Met Cys Ala Pro Arg Tyr Pro Ser Gly Gly Ala Trp Asp Pro His 
        515                 520                 525             


Pro Gly Gln Gly Phe Gly Glu Ser Met Tyr Leu Leu Ser Asp Lys Ala 
    530                 535                 540                 


Thr Ser Pro Leu Ser Leu Asp Ala Gly Leu Gly Gln Ala Pro Trp Ser 
545                 550                 555                 560 


Asp Leu Leu Leu Trp Ala Leu Leu Leu Asn Arg Ala Gln Met Ala Met 
                565                 570                 575     


Tyr Phe Trp Glu Met Gly Ser Asn Ala Val Ser Ser Ala Leu Gly Ala 
            580                 585                 590         


Cys Leu Leu Leu Arg Val Met Ala Arg Leu Glu Pro Asp Ala Glu Glu 
        595                 600                 605             


Ala Ala Arg Arg Lys Asp Leu Ala Phe Lys Phe Glu Gly Met Gly Val 
    610                 615                 620                 


Asp Leu Phe Gly Glu Cys Tyr Arg Ser Ser Glu Val Arg Ala Ala Arg 
625                 630                 635                 640 


Leu Leu Leu Arg Arg Cys Pro Leu Trp Gly Asp Ala Thr Cys Leu Gln 
                645                 650                 655     


Leu Ala Met Gln Ala Asp Ala Arg Ala Phe Phe Ala Gln Asp Gly Val 
            660                 665                 670         


Gln Ser Leu Leu Thr Gln Lys Trp Trp Gly Asp Met Ala Ser Thr Thr 
        675                 680                 685             


Pro Ile Trp Ala Leu Val Leu Ala Phe Phe Cys Pro Pro Leu Ile Tyr 
    690                 695                 700                 


Thr Arg Leu Ile Thr Phe Arg Lys Ser Glu Glu Glu Pro Thr Arg Glu 
705                 710                 715                 720 


Glu Leu Glu Phe Asp Met Asp Ser Val Ile Asn Gly Glu Gly Pro Val 
                725                 730                 735     


Gly Thr Ala Asp Pro Ala Glu Lys Thr Pro Leu Gly Val Pro Arg Gln 
            740                 745                 750         


Ser Gly Arg Pro Gly Cys Cys Gly Gly Arg Cys Gly Gly Arg Arg Cys 
        755                 760                 765             


Leu Arg Arg Trp Phe His Phe Trp Gly Ala Pro Val Thr Ile Phe Met 
    770                 775                 780                 


Gly Asn Val Val Ser Tyr Leu Leu Phe Leu Leu Leu Phe Ser Arg Val 
785                 790                 795                 800 


Leu Leu Val Asp Phe Gln Pro Ala Pro Pro Gly Ser Leu Glu Leu Leu 
                805                 810                 815     


Leu Tyr Phe Trp Ala Phe Thr Leu Leu Cys Glu Glu Leu Arg Gln Gly 
            820                 825                 830         


Leu Ser Gly Gly Gly Gly Ser Leu Ala Ser Gly Gly Pro Gly Pro Gly 
        835                 840                 845             


His Ala Ser Leu Ser Gln Arg Leu Arg Leu Tyr Leu Ala Asp Ser Trp 
    850                 855                 860                 


Asn Gln Cys Asp Leu Val Ala Leu Thr Cys Phe Leu Leu Gly Val Gly 
865                 870                 875                 880 


Cys Arg Leu Thr Pro Gly Leu Tyr His Leu Gly Arg Thr Val Leu Cys 
                885                 890                 895     


Ile Asp Phe Met Val Phe Thr Val Arg Leu Leu His Ile Phe Thr Val 
            900                 905                 910         


Asn Lys Gln Leu Gly Pro Lys Ile Val Ile Val Ser Lys Met Met Lys 
        915                 920                 925             


Asp Val Phe Phe Phe Leu Phe Phe Leu Gly Val Trp Leu Val Ala Tyr 
    930                 935                 940                 


Gly Val Ala Thr Glu Gly Leu Leu Arg Pro Arg Asp Ser Asp Phe Pro 
945                 950                 955                 960 


Ser Ile Leu Arg Arg Val Phe Tyr Arg Pro Tyr Leu Gln Ile Phe Gly 
                965                 970                 975     


Gln Ile Pro Gln Glu Asp Met Asp Val Ala Leu Met Glu His Ser Asn 
            980                 985                 990         


Cys Ser Ser Glu Pro Gly Phe Trp  Ala His Pro Pro Gly  Ala Gln Ala 
        995                 1000                 1005             


Gly Thr  Cys Val Ser Gln Tyr  Ala Asn Trp Leu Val  Val Leu Leu 
    1010                 1015                 1020             


Leu Val  Ile Phe Leu Leu Val  Ala Asn Ile Leu Leu  Val Asn Leu 
    1025                 1030                 1035             


Leu Ile  Ala Met Phe Ser Tyr  Thr Phe Gly Lys Val  Gln Gly Asn 
    1040                 1045                 1050             


Ser Asp  Leu Tyr Trp Lys Ala  Gln Arg Tyr Arg Leu  Ile Arg Glu 
    1055                 1060                 1065             


Phe His  Ser Arg Pro Ala Leu  Ala Pro Pro Phe Ile  Val Ile Ser 
    1070                 1075                 1080             


His Leu  Arg Leu Leu Leu Arg  Gln Leu Cys Arg Arg  Pro Arg Ser 
    1085                 1090                 1095             


Pro Gln  Pro Ser Ser Pro Ala  Leu Glu His Phe Arg  Val Tyr Leu 
    1100                 1105                 1110             


Ser Lys  Glu Ala Glu Arg Lys  Leu Leu Thr Trp Glu  Ser Val His 
    1115                 1120                 1125             


Lys Glu  Asn Phe Leu Leu Ala  Arg Ala Arg Asp Lys  Arg Glu Ser 
    1130                 1135                 1140             


Asp Ser  Glu Arg Leu Lys Arg  Thr Ser Gln Lys Val  Asp Leu Ala 
    1145                 1150                 1155             


Leu Lys  Gln Leu Gly His Ile  Arg Glu Tyr Glu Gln  Arg Leu Lys 
    1160                 1165                 1170             


Val Leu  Glu Arg Glu Val Gln  Gln Cys Ser Arg Val  Leu Gly Trp 
    1175                 1180                 1185             


Val Ala  Glu Ala Leu Ser Arg  Ser Ala Leu Leu Pro  Pro Gly Gly 
    1190                 1195                 1200             


Pro Pro  Pro Pro Asp Leu Pro  Gly Ser Lys Asp 
    1205                 1210                 


<210>  4316
<211>  2916
<212>  PRT
<213>  Homo sapiens

<400>  4316

Met Arg Leu Asp Glu Ile Thr Lys Ser Glu Asn Glu Asp Gly Glu Lys 
1               5                   10                  15      


Lys Met Phe Thr Gln Gln Phe Glu Ser Thr Asp Ala Cys Val Tyr Glu 
            20                  25                  30          


Val Tyr Val Lys Ile Asn Ser Ile Val Lys Ser Gln Ser Gln Cys Gly 
        35                  40                  45              


Leu Lys Arg Gly Ser Pro Glu Thr Glu Leu Trp Gly Ala Ile Val Phe 
    50                  55                  60                  


Arg Ser Gln Glu Glu Asn Ala Lys Pro Val Lys Glu Thr Glu Val Thr 
65                  70                  75                  80  


Ala Ser Asp Ala Asp Ser Gly Leu Tyr Gly Phe Ile Glu Tyr Ser Leu 
                85                  90                  95      


Tyr Asp Gly Phe Leu Ser Tyr Glu Ala Pro Gln Ala Phe Arg Ile Asp 
            100                 105                 110         


Pro His Asp Gly Gln Ile Cys Val Ser Gln Asp Ile Asp Arg Glu Arg 
        115                 120                 125             


Asp Pro Ala Thr Tyr Asp Leu Leu Val Glu Ala Lys Asp Gly Asp Glu 
    130                 135                 140                 


Gln Arg Met Thr His Leu Ala Leu Val Lys Gly Gly Leu Ser Ala Gln 
145                 150                 155                 160 


Ala Phe Val Arg Val Asp Leu Glu Asp Val Asn Asp Asn His Pro Val 
                165                 170                 175     


Phe Asn Pro Ser Thr Tyr Val Thr Ser Ile Ser Asp Glu Thr Gln Pro 
            180                 185                 190         


Gly Thr Glu Ile Ile Asn Val Leu Ala Thr Asp Gln Asp Ser Gly Ile 
        195                 200                 205             


Tyr Gly Thr Val Ala Tyr Glu Leu Ile Pro Gly Asn Val Ser Ser Leu 
    210                 215                 220                 


Phe Thr Ile Asp Ser Thr Thr Gly Leu Tyr Ser Pro Glu Val Glu Ile 
225                 230                 235                 240 


Leu Ser Ala Val Asn Phe Ser Ala Asp Lys Glu Val Met Asn Ser Leu 
                245                 250                 255     


Glu Met Phe Leu Pro Leu Leu Arg His Phe Lys Lys Val Glu Arg Asp 
            260                 265                 270         


Glu Glu Ala Ala Glu Lys Lys Phe Glu Ala Ser Arg Gly Trp Phe Met 
        275                 280                 285             


Arg Phe Lys Gly Arg Arg His Leu His Tyr Leu Lys Val Gln Asp Glu 
    290                 295                 300                 


Ala Ala Ser Ala Asp Gly Glu Ala Ala Ala Arg Tyr Val Ala Asn Leu 
305                 310                 315                 320 


Ala Lys Ile Leu Gly Glu Gly Ile Ile Tyr Leu Thr Leu Pro Leu Ser 
                325                 330                 335     


His Leu Glu Ser Thr Thr Leu Ser Leu Met Val Ser Ala Gln Asp Gly 
            340                 345                 350         


Gly Gly Leu Thr Ala Val Ile Asn Ala Asp Val Thr Ile His Ile Phe 
        355                 360                 365             


Gln Thr Thr Leu Ala Pro Ala Glu Phe Glu Arg Pro Lys Tyr Thr Phe 
    370                 375                 380                 


Leu Val Tyr Glu Asp Val Pro Glu Asp Ser Pro Ile Gly Thr Val Lys 
385                 390                 395                 400 


Ala Arg Glu Pro Leu Asn Ser Ser Glu Pro Ile Phe Tyr Arg Ile Ser 
                405                 410                 415     


Ser Gly Asp Leu Gly Gly Lys Phe Ser Ile His Pro Arg Leu Gly Thr 
            420                 425                 430         


Ile Arg Thr Arg Lys Pro Leu Asp His Glu Thr Gln Pro Val Val Val 
        435                 440                 445             


Leu Thr Val Gln Ala Gln Leu Gly Ser Ala Pro Ala Cys Ser Ser Thr 
    450                 455                 460                 


Glu Val Asn Ile Thr Val Met Asp Val Asn Asp Asn His Pro Ala Phe 
465                 470                 475                 480 


Leu Arg Thr Ser Asp Glu Ile Arg Ile Ser Gln Thr Thr Pro Pro Gly 
                485                 490                 495     


Thr Ala Leu Tyr Leu Ala Arg Ala Glu Asp Arg Asp Ser Gly Arg Asn 
            500                 505                 510         


Gly Leu Ile Arg Tyr Ser Ile Ala Ser Pro Gln Pro Gly Val Phe Ala 
        515                 520                 525             


Ile Asp Arg Ala Leu Gly Val Leu Phe Leu Asn Gly Ser Leu Gly Ala 
    530                 535                 540                 


Gly Glu Gln Arg Glu Leu Thr Leu Thr Leu Arg Ala Glu Asp Gln Gly 
545                 550                 555                 560 


Val His Pro Gln Ala Ala Leu Leu Val Leu Thr Val Val Ile Glu Lys 
                565                 570                 575     


Arg Glu His Ser Pro Ser Trp Thr Phe Glu His Leu Val Tyr Gln Val 
            580                 585                 590         


Glu Val Ser Glu Ser Leu Ser Pro Met Thr Gln Met Leu Gln Thr Gln 
        595                 600                 605             


Ala His Pro Leu Gly Pro Gln Arg Ala Ala Ser Pro Leu Arg Tyr Ser 
    610                 615                 620                 


Leu Glu Pro Ser Val Asp Ser Ala Met Phe Gly Ile Arg Pro Tyr Thr 
625                 630                 635                 640 


Gly Trp Ile Tyr Leu Arg Arg Gln Phe Asp Tyr Glu Ser Thr Gln Thr 
                645                 650                 655     


Tyr Asn Phe Arg Val Phe Ala Trp Ile Pro Glu Asp Gly Phe Leu Gln 
            660                 665                 670         


Asn Val Ser Thr Thr Val Ile Val Arg Val Trp Asp Glu Asn Asp Asn 
        675                 680                 685             


Ser Pro Thr Phe Leu His Asp Val Leu Phe Leu Lys Val Glu Glu Ser 
    690                 695                 700                 


Pro Val Pro Gln Gly Val Ile Gly Lys Ile Thr Ala Ile Asp Met Asp 
705                 710                 715                 720 


Ser Gly Lys Asn Gly Gln Leu Leu Tyr Phe Leu Leu Ser Asp Gly Lys 
                725                 730                 735     


Phe Phe Lys Met Asn Pro Asn Thr Gly Pro Ala Gly Thr Ile Tyr Val 
            740                 745                 750         


Ile Thr Trp Ala Asp Gly Ala Ala Ala Phe Ser Gly Thr Asp Phe Ala 
        755                 760                 765             


Phe Ser Ser Asp Glu Leu Gln Ala Phe Val Leu Lys Ser Leu Phe Cys 
    770                 775                 780                 


Glu Leu Gly Glu Gly Glu Leu Ile Asn Trp Val Ala Leu Asp Arg Glu 
785                 790                 795                 800 


His Arg Gly His His Glu Met Thr Val Leu Val Thr Asp Arg Gly Ser 
                805                 810                 815     


Pro Pro Arg Asn Ala Thr Met Ala Val Tyr Val Ser Val Thr Asp Ile 
            820                 825                 830         


Asn Asp Asn Arg Pro Phe Phe Pro Gln Cys Leu Pro Gly Lys Glu Leu 
        835                 840                 845             


His Val Lys Val Leu Glu Gly Gln Pro Val Asn Met Leu Val Thr Thr 
    850                 855                 860                 


Val Phe Ala Lys Asp Pro Asp Glu Gly Asn Asn Ala Glu Val Thr Tyr 
865                 870                 875                 880 


Ser Val Ser Ser Glu Asp Ser Ser Asp His Phe Lys Ile Asp Ala Asn 
                885                 890                 895     


Asn Gly Glu Ile Arg Thr Thr Thr Ile Leu Ser Tyr Asp Tyr Arg Pro 
            900                 905                 910         


Ser Tyr Arg Met Ser Val Ile Ala Thr Asp Gln Gly Val Pro Pro Leu 
        915                 920                 925             


Gln Gly Gln Ala Val Val Asn Ile Gln Val Ile Pro Leu Ser Lys Gly 
    930                 935                 940                 


Arg Ala Ile Met Ser Gln Asn Ile Arg His Leu Ile Ile Pro Glu Asn 
945                 950                 955                 960 


Leu Lys Pro Thr Lys Ile Met Ser Leu Ile Lys Ser Ser Asp His Leu 
                965                 970                 975     


Gln Gln His Tyr Asn Gly Lys Leu His Phe Ser Ile Val Ala Asp Asp 
            980                 985                 990         


Lys Asp Gly His Phe Glu Ile Asp  Ser Ser Thr Gly Asp  Leu Phe Leu 
        995                 1000                 1005             


Ser Lys  Glu Leu Asp Tyr Glu  Thr Thr Ser His Tyr  Leu Phe Arg 
    1010                 1015                 1020             


Val Ile  Thr Thr Asp His Ser  Lys Asn Leu Ser Leu  Ser Ser Thr 
    1025                 1030                 1035             


Val Phe  Leu Ser Ile Asp Val  Glu Asp Gln Asn Asp  His Ser Pro 
    1040                 1045                 1050             


Ser Phe  Gln Asp Glu Leu Ile  Val Ile Ser Val Glu  Glu Asn Val 
    1055                 1060                 1065             


Pro Ile  Gly Thr Leu Val Tyr  Val Phe Asn Ala Lys  Asp Asp Asp 
    1070                 1075                 1080             


Gly Ser  Phe Leu Asn Ser Arg  Ile Gln Tyr Tyr Ile  Glu Ser His 
    1085                 1090                 1095             


Asn Pro  Gly Thr Asn Pro Phe  Leu Ile His Pro Ser  Phe Gly Thr 
    1100                 1105                 1110             


Leu Val  Thr Val Ser Arg Leu  Asp Arg Glu Ser Ile  Pro Thr Val 
    1115                 1120                 1125             


Ile Leu  Thr Val Thr Ala Ser  Asp Gln Ala Val Asn  Val Thr Asp 
    1130                 1135                 1140             


Arg Arg  Leu Arg Ser Leu Thr  Ala Gln Ile Val Ile  Leu Asp Val 
    1145                 1150                 1155             


Asn Asp  His Asn Pro Thr Phe  Ile Ser Phe Pro Asn  Ala His Val 
    1160                 1165                 1170             


Lys Glu  Asp Val Thr Val Gly  Ser Leu Val His His  Ile Thr Ala 
    1175                 1180                 1185             


His Asp  Pro Asp Glu Gly Arg  Asn Gly Lys Val Thr  Tyr Ser Ile 
    1190                 1195                 1200             


Leu Ser  Gly Asn Glu Asn Met  Thr Phe Met Leu Asp  Glu Ser Ser 
    1205                 1210                 1215             


Gly Leu  Leu Thr Thr Thr Cys  Pro Leu Asp Tyr Glu  Met Lys Thr 
    1220                 1225                 1230             


Gln His  Ile Leu Thr Val Leu  Ala Leu Asp Asp Gly  Thr Pro Ala 
    1235                 1240                 1245             


Leu Ser  Ser Ser Gln Thr Leu  Thr Val Thr Val Leu  Asp Val Asn 
    1250                 1255                 1260             


Asp Glu  Ala Pro Val Phe Lys  Gln His Leu Tyr Glu  Ala Ser Val 
    1265                 1270                 1275             


Lys Glu  Asn Gln Asn Pro Gly  Glu Phe Val Thr Arg  Val Glu Ala 
    1280                 1285                 1290             


Leu Asp  Arg Asp Ser Gly Val  Asn Ser Lys Leu Gln  Phe Glu Ile 
    1295                 1300                 1305             


Met Pro  Gly Ala Ser Phe Glu  Leu Phe Glu Ile Asn  Ser Asp Thr 
    1310                 1315                 1320             


Gly Glu  Val Val Thr Thr Thr  Ile Leu Asp Arg Glu  Ile Gln Glu 
    1325                 1330                 1335             


Val Phe  Thr Leu Arg Val Leu  Val Arg Asp Gly Gly  Phe Pro Ser 
    1340                 1345                 1350             


Leu Ser  Ser Thr Thr Thr Ile  Leu Cys Thr Val Glu  Asp Glu Asn 
    1355                 1360                 1365             


Asp His  Ala Pro Glu Phe Ile  Val Ser Ser Tyr Asp  Ile Glu Val 
    1370                 1375                 1380             


Leu Glu  Asn Gln Glu Pro Glu  Val Val Tyr Thr Val  Leu Ala Ser 
    1385                 1390                 1395             


Asp Met  Asp Ala Gly Asn Asn  Arg Ala Val Glu Tyr  His Ile Ile 
    1400                 1405                 1410             


Asp Gly  Asn Thr Asp Glu Cys  Phe Thr Ile Asn Glu  Met Ser Gly 
    1415                 1420                 1425             


Glu Leu  Ser Thr Thr Arg Ala  Leu Asp Arg Glu Gln  Ile Ser Asn 
    1430                 1435                 1440             


Phe Thr  Leu Val Ile Leu Cys  Ser Asp Leu Gly Asp  Pro Pro Arg 
    1445                 1450                 1455             


Ser Ser  Val Ile His Leu Gln  Val Arg Val Leu Asp  Ala Asn Asp 
    1460                 1465                 1470             


His Ser  Pro Ser Phe Pro Thr  Leu Tyr Tyr Gln Ser  Ser Val Arg 
    1475                 1480                 1485             


Glu Asp  Ala Glu Val Gly Thr  Val Val Leu Val Leu  Ser Ala Val 
    1490                 1495                 1500             


Asp Lys  Asp Glu Gly Leu Asn  Gly Gln Thr Glu Tyr  Phe Leu Thr 
    1505                 1510                 1515             


Asp Glu  Ala Ser Gly Ala Phe  Thr Ile Asp Pro Met  Ser Gly Thr 
    1520                 1525                 1530             


Leu Lys  Thr Ser Asn Thr Leu  Asp Arg Glu Ala Arg  Ser Gln His 
    1535                 1540                 1545             


Thr Phe  Ser Ala Val Ala Arg  Asp Cys Ser Ile Gln  Gly Ser Arg 
    1550                 1555                 1560             


Ser Thr  Thr Val Ile Ile Lys  Val Tyr Val Thr Asp  Val Asn Asp 
    1565                 1570                 1575             


Asn Asp  Pro Val Leu Glu Gln  Asn Pro Phe Asp Val  Phe Leu Ser 
    1580                 1585                 1590             


Pro Glu  Ser Pro Thr Asn Gln  Thr Thr Val Ile Val  Arg Ala Asp 
    1595                 1600                 1605             


Asp Leu  Asp Leu Gly Pro Asn  Gly Thr Val Val Phe  Ser Phe Ala 
    1610                 1615                 1620             


Glu Thr  Gln Ser Met Phe Ser  Ile Asp Lys Tyr Thr  Gly Glu Ile 
    1625                 1630                 1635             


Gln Phe  Gln Gln Asn Pro Ser  Ser Glu Tyr Phe Pro  Ile Trp Leu 
    1640                 1645                 1650             


Gln Leu  Lys Val Thr Asp Gln  Gly Ile Pro Ala Arg  Thr Thr Thr 
    1655                 1660                 1665             


Gly Leu  Leu Val Ile His Met  Glu Gly Glu Asp Val  Lys Ile Ser 
    1670                 1675                 1680             


Phe Ser  His His Leu Tyr Lys  Gly Leu Val Thr Glu  Asn Cys Glu 
    1685                 1690                 1695             


Ala Gly  Thr Ser Ile Val Thr  Val Lys Ala Phe Ala  Pro Asp Ser 
    1700                 1705                 1710             


Ile Gln  Asp Ser Met Lys Tyr  Ser Ile Phe Ser Gly  Asn Glu Asp 
    1715                 1720                 1725             


Gly Val  Leu Ser Leu Cys Ser  Lys Ser Gly Gln Leu  Thr Val Lys 
    1730                 1735                 1740             


Glu Pro  Lys Phe Leu Asp Phe  Glu Val Arg Asn Glu  Val Gln Leu 
    1745                 1750                 1755             


Ile Val  Leu Ala Glu Ser Ser  Gly His Arg Ala Tyr  Cys Lys Val 
    1760                 1765                 1770             


Ala Val  Leu Ile Gln Asp Glu  Asn Asp Asn Ser Pro  Cys Phe Glu 
    1775                 1780                 1785             


Gln Ser  Ile Tyr Gln Ala Ser  Val Ser Glu Ser Gln  Leu Tyr Asn 
    1790                 1795                 1800             


Ala His  Val Ile Gln Val Phe  Ala Thr Asp Leu Asp  Ser Gly Leu 
    1805                 1810                 1815             


Asn Gly  Leu Ile Glu Tyr Ser  Ile Leu Ser Gly Asn  Gln Glu Glu 
    1820                 1825                 1830             


Ala Phe  Gln Ile Asp Ala Leu  Ser Gly Val Ile Thr  Thr Lys Ala 
    1835                 1840                 1845             


Ile Leu  Asp Tyr Glu Leu Thr  Ser Ser Tyr Ser Leu  Ile Val Gln 
    1850                 1855                 1860             


Ala Thr  Asp Lys Gly Met Pro  Arg Leu Ser Asn Thr  Thr Val Ile 
    1865                 1870                 1875             


Lys Val  Gln Val Thr Asp Ile  Asn Asp Asn Ala Pro  Ala Phe Leu 
    1880                 1885                 1890             


Pro Ser  Glu Ala Val Glu Ile  Thr Glu Asp Ser Leu  Pro Gly Val 
    1895                 1900                 1905             


Ile Val  Thr His Val Ser Val  His Asp Val Asp Leu  Asn Ser Ala 
    1910                 1915                 1920             


Phe Ile  Phe Ser Phe Ala Lys  Glu Ser Asn Pro Gly  Thr Lys Phe 
    1925                 1930                 1935             


Ala Ile  Asp Gln Asn Thr Gly  Val Val Val Leu Val  Lys Thr Leu 
    1940                 1945                 1950             


Asp Phe  Glu Glu Met Thr Glu  Tyr Glu Leu Leu Ile  Gln Ile Ser 
    1955                 1960                 1965             


Asp Ser  Val His Tyr Thr Glu  Gly Ala Leu Val Val  Arg Val Leu 
    1970                 1975                 1980             


Asp Val  Asn Asp Asn Pro Pro  Val Phe Ser Gln Asp  Phe Tyr Gln 
    1985                 1990                 1995             


Val Thr  Val Pro Glu Ser Ile  Pro Val Gly Tyr Ser  Val Leu Thr 
    2000                 2005                 2010             


Leu Ser  Ala Thr Asp Leu Glu  Ser Asn Glu Asn Ile  Ser Tyr Arg 
    2015                 2020                 2025             


Ile Leu  Ser Ser Ser Lys Glu  Phe Ser Ile Asp Pro  Lys Asn Gly 
    2030                 2035                 2040             


Thr Ile  Phe Thr Ile Ser Pro  Val Leu Leu Leu Asp  Thr Ile Ser 
    2045                 2050                 2055             


Thr Thr  Gln Phe Leu Val Glu  Ala Ser Asp Gly Gly  Asn Pro Asp 
    2060                 2065                 2070             


Leu Arg  Ala Leu Thr Leu Val  Glu Ile Gly Ile Glu  Asp Met Asn 
    2075                 2080                 2085             


Asn Tyr  Ala Pro Glu Phe Thr  Val Lys Ser Tyr Asn  Leu Ser Leu 
    2090                 2095                 2100             


Ser Glu  Asp Ala Leu Val Gly  Ser Thr Leu Val Thr  Phe Ser Asn 
    2105                 2110                 2115             


Ile Asp  His Asp Trp Thr Arg  Glu Asn Thr Tyr Val  Glu Tyr Ser 
    2120                 2125                 2130             


Ile Ile  Ser Gly Asn Ser Gln  Asn Asn Phe His Val  Glu Thr Lys 
    2135                 2140                 2145             


Phe Phe  His Ser Glu Tyr Pro  Tyr Lys Gln Val Gly  Tyr Leu Val 
    2150                 2155                 2160             


Leu Leu  His Ser Leu Asp Arg  Glu Ala Ser Ala Ser  His Glu Leu 
    2165                 2170                 2175             


Val Ile  Leu Ala Ser Asp Ser  Gly Cys Pro Pro Leu  Ser Ser Thr 
    2180                 2185                 2190             


Ala Val  Ile Ser Ile Gln Val  Leu Asp Val Asn Asp  Asn Pro Pro 
    2195                 2200                 2205             


Asn Phe  Ser Ser Leu Ser Tyr  His Thr His Val Lys  Glu Ser Thr 
    2210                 2215                 2220             


Pro Leu  Gly Ser His Ile Thr  Val Val Ser Ala Asn  Asp Arg Asp 
    2225                 2230                 2235             


Thr Gly  Ser His Ala Glu Ile  Ile Tyr Asn Ile Ile  Ser Gly Asn 
    2240                 2245                 2250             


Glu Lys  Gly His Phe Tyr Leu  Glu Glu Asn Thr Gly  Val Leu Tyr 
    2255                 2260                 2265             


Leu Ile  Lys Pro Leu Asp Tyr  Glu Lys Met Thr Lys  Phe Thr Leu 
    2270                 2275                 2280             


Thr Val  Gln Ala Ser Asp Ala  Glu Lys Lys His Phe  Ser Phe Ala 
    2285                 2290                 2295             


Val Val  Phe Val Ser Val Leu  Asp Asp Asn Asp His  Ala Pro Gln 
    2300                 2305                 2310             


Phe Met  Phe Ser Ser Phe Ser  Cys Ile Val Pro Glu  Asn Leu Pro 
    2315                 2320                 2325             


Ile Ser  Ser Thr Ile Cys Ser  Ile Asn Ala Leu Asp  Phe Asp Ala 
    2330                 2335                 2340             


Gly Pro  Tyr Gly Glu Leu Thr  Tyr Ser Ile Val Ser  Pro Cys Phe 
    2345                 2350                 2355             


Leu Thr  His Gly Met Ser Tyr  Asp His Asp Leu Phe  Leu Ile Asp 
    2360                 2365                 2370             


Pro Leu  Thr Gly Asp Ile His  Ala Lys Gln Ile Leu  Asp Tyr Glu 
    2375                 2380                 2385             


Asn Gly  Asn Lys Tyr Cys Leu  Thr Val Gln Ala Lys  Asp Lys Gly 
    2390                 2395                 2400             


Asp Ala  Thr Ala Ser Leu Val  Val Trp Val Asp Ile  Glu Gly Ile 
    2405                 2410                 2415             


Asp Glu  Phe Glu Pro Ile Phe  Thr Gln Asp Gln Tyr  Phe Phe Thr 
    2420                 2425                 2430             


Leu Pro  Glu Lys Asn Lys Asp  Arg Gln Leu Ile Gly  Arg Val Glu 
    2435                 2440                 2445             


Ala Ser  Asp Ala Asp Ala Gly  Ile Asp Gly Val Ile  Leu Tyr Ser 
    2450                 2455                 2460             


Leu Gly  Thr Ser Ser Pro Phe  Phe Ser Val Asn Lys  Thr Asn Gly 
    2465                 2470                 2475             


Asn Ile  Tyr Leu Ile Arg Ala  Leu Pro Leu Ile Lys  Ser Gln Leu 
    2480                 2485                 2490             


Asn Lys  Glu Asp Thr Leu Glu  Met Lys Ile Ile Ala  His Ser Pro 
    2495                 2500                 2505             


Lys Ser  Asp Ser Lys Phe Ala  Ser Cys Thr Val Phe  Val Asn Val 
    2510                 2515                 2520             


Ser Phe  Ser Ser Glu Gly Thr  Pro Leu Ala Val Phe  Ala Ser Ser 
    2525                 2530                 2535             


Phe Ser  Ile Ser Leu Val Val  Ser Phe Leu Val Phe  Leu Ile Leu 
    2540                 2545                 2550             


Ile Cys  Ile Leu Ile Val Met  Ile Leu Arg His Lys  Gln Lys Asp 
    2555                 2560                 2565             


Thr Ile  Asn Asn Tyr Glu Glu  Lys Lys Thr Ser Ser  Leu Asp Ala 
    2570                 2575                 2580             


Asp Leu  Arg Val Thr Arg Asp  Ala Ser Val Leu Lys  Ala Phe Gln 
    2585                 2590                 2595             


Lys Thr  Asp Asp Cys Ser Asn  Glu Val Val Pro Val  Asp Ala Thr 
    2600                 2605                 2610             


Pro Glu  Trp Leu Ser Leu Ile  Ser Ile Met Glu Lys  Asp Ile Val 
    2615                 2620                 2625             


Asn Leu  Tyr Arg His Ser Asn  Ser Ser Gly His Cys  Ser Val Glu 
    2630                 2635                 2640             


Gly Glu  Thr Ala Glu Asp Lys  Glu Ile Gln Arg Ile  Asn Glu His 
    2645                 2650                 2655             


Pro Tyr  Arg Lys Cys Ser Asp  Ser Ala Leu Ser Asp  His Glu Ser 
    2660                 2665                 2670             


Arg Val  Pro Asp Ser Gly Ile  Pro Arg Asp Ser Asp  Gln Leu Ser 
    2675                 2680                 2685             


Cys Leu  Ser Gly Glu Thr Asp  Val Met Val Thr Ala  Glu Thr Ala 
    2690                 2695                 2700             


Glu Ala  Ser Gln Thr Phe Gly  Glu Gly Asp Gln Gly  Glu Gly Cys 
    2705                 2710                 2715             


Ser Thr  Thr Cys Ala Gln Asn  Asn Val Leu Pro Gln  Thr Val Gln 
    2720                 2725                 2730             


Lys Arg  Glu Ala Lys Glu Ser  Ile Leu Ala Asp Val  Arg Lys Glu 
    2735                 2740                 2745             


Ser Val  Phe Ile Ser Gly Asp  Gln Glu Val Arg Cys  Ala Ala Leu 
    2750                 2755                 2760             


Ser Thr  Gln Thr Thr Ser Asp  His Asp Gly Lys Asp  Asn Tyr His 
    2765                 2770                 2775             


Trp Asn  Tyr Leu Leu Ser Trp  Glu Pro Lys Phe Gln  Pro Leu Ala 
    2780                 2785                 2790             


Ser Val  Phe Asn Asp Ile Ala  Lys Leu Lys Asp Glu  His Leu His 
    2795                 2800                 2805             


Met Pro  Gly Ile Pro Lys Glu  Lys Lys Ser Phe Val  Phe Pro Pro 
    2810                 2815                 2820             


Pro Leu  Ile Thr Ala Val Ala  Gln Pro Gly Ile Lys  Ala Val Pro 
    2825                 2830                 2835             


Pro Arg  Met Pro Ala Val Asn  Leu Gly Gln Val Pro  Pro Lys His 
    2840                 2845                 2850             


Pro Arg  Ser Pro Ile Pro Tyr  His Leu Gly Ser Leu  Pro Glu Gly 
    2855                 2860                 2865             


Met Thr  Pro Asn Phe Ser Pro  Ser Leu Ser Leu Leu  Thr Met Gln 
    2870                 2875                 2880             


Pro Pro  Ala Leu Ser Pro Leu  Leu Arg Glu Gly Glu  Leu Leu Gly 
    2885                 2890                 2895             


Thr His  Ile Ser Gly Thr Cys  His Glu Leu Lys Ala  Glu Asp Glu 
    2900                 2905                 2910             


Val Gln  Ile 
    2915     


<210>  4317
<211>  875
<212>  PRT
<213>  Homo sapiens

<400>  4317

Met Ile Gly Cys Gly Ala Cys Glu Pro Lys Val Lys Met Ala Gly Gly 
1               5                   10                  15      


Gln Ala Ala Ala Ala Leu Pro Thr Trp Lys Met Ala Ala Arg Arg Ser 
            20                  25                  30          


Leu Ser Ala Arg Gly Arg Gly Ile Leu Gln Ala Ala Ala Gly Arg Leu 
        35                  40                  45              


Leu Pro Leu Leu Leu Leu Ser Cys Cys Cys Gly Ala Gly Gly Cys Ala 
    50                  55                  60                  


Ala Val Gly Glu Asn Glu Glu Thr Val Ile Ile Gly Leu Arg Leu Glu 
65                  70                  75                  80  


Asp Thr Asn Asp Val Ser Phe Met Glu Gly Gly Ala Leu Arg Val Ser 
                85                  90                  95      


Glu Arg Thr Arg Val Lys Leu Arg Val Tyr Gly Gln Asn Ile Asn Asn 
            100                 105                 110         


Glu Thr Trp Ser Arg Ile Ala Phe Thr Glu His Glu Arg Arg Arg His 
        115                 120                 125             


Ser Pro Gly Glu Arg Gly Leu Gly Gly Pro Ala Pro Pro Glu Pro Asp 
    130                 135                 140                 


Ser Gly Pro Gln Arg Cys Gly Ile Arg Thr Ser Asp Ile Ile Ile Leu 
145                 150                 155                 160 


Pro His Ile Ile Leu Asn Arg Arg Thr Ser Gly Ile Ile Glu Ile Glu 
                165                 170                 175     


Ile Lys Pro Leu Arg Lys Met Glu Lys Ser Lys Ser Tyr Tyr Leu Cys 
            180                 185                 190         


Thr Ser Leu Ser Thr Pro Ala Leu Gly Ala Gly Gly Ser Gly Ser Thr 
        195                 200                 205             


Gly Gly Ala Val Gly Gly Lys Gly Gly Ser Gly Val Ala Gly Leu Pro 
    210                 215                 220                 


Pro Pro Pro Trp Ala Glu Thr Thr Trp Ile Tyr His Asp Gly Glu Asp 
225                 230                 235                 240 


Thr Lys Met Ile Val Gly Glu Glu Lys Lys Phe Leu Leu Pro Phe Trp 
                245                 250                 255     


Leu Gln Val Ile Phe Ile Ser Leu Leu Leu Cys Leu Ser Gly Met Phe 
            260                 265                 270         


Ser Gly Leu Asn Leu Gly Leu Met Ala Leu Asp Pro Met Glu Leu Arg 
        275                 280                 285             


Ile Val Gln Asn Cys Gly Thr Glu Lys Glu Lys Asn Tyr Ala Lys Arg 
    290                 295                 300                 


Ile Glu Pro Val Arg Arg Gln Gly Asn Tyr Leu Leu Cys Ser Leu Leu 
305                 310                 315                 320 


Leu Gly Asn Val Leu Val Asn Thr Thr Leu Thr Ile Leu Leu Asp Asp 
                325                 330                 335     


Ile Ala Gly Ser Gly Leu Val Ala Val Val Val Ser Thr Ile Gly Ile 
            340                 345                 350         


Val Ile Phe Gly Glu Ile Val Pro Gln Ala Ile Cys Ser Arg His Gly 
        355                 360                 365             


Leu Ala Val Gly Ala Asn Thr Ile Phe Leu Thr Lys Phe Phe Met Met 
    370                 375                 380                 


Met Thr Phe Pro Ala Ser Tyr Pro Val Ser Lys Leu Leu Asp Cys Val 
385                 390                 395                 400 


Leu Gly Gln Glu Ile Gly Thr Val Tyr Asn Arg Glu Lys Leu Leu Glu 
                405                 410                 415     


Met Leu Arg Val Thr Asp Pro Tyr Asn Asp Leu Val Lys Glu Glu Leu 
            420                 425                 430         


Asn Ile Ile Gln Gly Ala Leu Glu Leu Arg Thr Lys Thr Val Glu Asp 
        435                 440                 445             


Val Met Thr Pro Leu Arg Asp Cys Phe Met Ile Thr Gly Glu Ala Ile 
    450                 455                 460                 


Leu Asp Phe Asn Thr Met Ser Glu Ile Met Glu Ser Gly Tyr Thr Arg 
465                 470                 475                 480 


Ile Pro Val Phe Glu Gly Glu Arg Ser Asn Ile Val Asp Leu Leu Phe 
                485                 490                 495     


Val Lys Asp Leu Ala Phe Val Asp Pro Asp Asp Cys Thr Pro Leu Lys 
            500                 505                 510         


Thr Ile Thr Lys Phe Tyr Asn His Pro Leu His Phe Val Phe Asn Asp 
        515                 520                 525             


Thr Lys Leu Asp Ala Met Leu Glu Glu Phe Lys Lys Gly Lys Ser His 
    530                 535                 540                 


Leu Ala Ile Val Gln Arg Val Asn Asn Glu Gly Glu Gly Asp Pro Phe 
545                 550                 555                 560 


Tyr Glu Val Leu Gly Ile Val Thr Leu Glu Asp Val Ile Glu Glu Ile 
                565                 570                 575     


Ile Lys Ser Glu Ile Leu Asp Glu Thr Asp Leu Tyr Thr Asp Asn Arg 
            580                 585                 590         


Thr Lys Lys Lys Val Ala His Arg Glu Arg Lys Gln Asp Phe Ser Ala 
        595                 600                 605             


Phe Lys Gln Thr Asp Ser Glu Met Lys Val Lys Ile Ser Pro Gln Leu 
    610                 615                 620                 


Leu Leu Ala Met His Arg Phe Leu Ala Thr Glu Val Glu Ala Phe Ser 
625                 630                 635                 640 


Pro Ser Gln Met Ser Glu Lys Ile Leu Leu Arg Leu Leu Lys His Pro 
                645                 650                 655     


Asn Val Ile Gln Glu Leu Lys Tyr Asp Glu Lys Asn Lys Lys Ala Pro 
            660                 665                 670         


Glu Tyr Tyr Leu Tyr Gln Arg Asn Lys Pro Val Asp Tyr Phe Val Leu 
        675                 680                 685             


Ile Leu Gln Gly Lys Val Glu Val Glu Ala Gly Lys Glu Gly Met Lys 
    690                 695                 700                 


Phe Glu Ala Ser Ala Phe Ser Tyr Tyr Gly Val Met Ala Leu Thr Ala 
705                 710                 715                 720 


Ser Pro Val Pro Leu Ser Leu Ser Arg Thr Phe Val Val Ser Arg Thr 
                725                 730                 735     


Glu Leu Leu Ala Ala Gly Ser Pro Gly Glu Asn Lys Ser Pro Pro Arg 
            740                 745                 750         


Pro Cys Gly Leu Asn His Ser Asp Ser Leu Ser Arg Ser Asp Arg Ile 
        755                 760                 765             


Asp Ala Val Thr Pro Thr Leu Gly Ser Ser Asn Asn Gln Leu Asn Ser 
    770                 775                 780                 


Ser Leu Leu Gln Val Tyr Ile Pro Asp Tyr Ser Val Arg Ala Leu Ser 
785                 790                 795                 800 


Asp Leu Gln Phe Val Lys Ile Ser Arg Gln Gln Tyr Gln Asn Ala Leu 
                805                 810                 815     


Met Ala Ser Arg Met Asp Lys Thr Pro Gln Ser Ser Asp Ser Glu Asn 
            820                 825                 830         


Thr Lys Ile Glu Leu Thr Leu Thr Glu Leu His Asp Gly Leu Pro Asp 
        835                 840                 845             


Glu Thr Ala Asn Leu Leu Asn Glu Gln Asn Cys Val Thr His Ser Lys 
    850                 855                 860                 


Ala Asn His Ser Leu His Asn Glu Gly Ala Ile 
865                 870                 875 


<210>  4318
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  4318

Met Arg Ser Gly Gly Arg Gly Arg Pro Arg Leu Arg Leu Gly Glu Arg 
1               5                   10                  15      


Gly Leu Met Glu Pro Leu Leu Pro Pro Lys Arg Arg Leu Leu Pro Arg 
            20                  25                  30          


Val Arg Leu Leu Pro Leu Leu Leu Ala Leu Ala Val Gly Ser Ala Phe 
        35                  40                  45              


Tyr Thr Ile Trp Ser Gly Trp His Arg Arg Thr Glu Glu Leu Pro Leu 
    50                  55                  60                  


Gly Arg Glu Leu Arg Val Pro Leu Ile Gly Ser Leu Pro Glu Ala Arg 
65                  70                  75                  80  


Leu Arg Arg Val Val Gly Gln Leu Asp Pro Gln Arg Leu Trp Ser Thr 
                85                  90                  95      


Tyr Leu Arg Pro Leu Leu Val Val Arg Thr Pro Gly Ser Pro Gly Asn 
            100                 105                 110         


Leu Gln Val Arg Lys Phe Leu Glu Ala Thr Leu Arg Ser Leu Thr Ala 
        115                 120                 125             


Gly Trp His Val Glu Leu Asp Pro Phe Thr Ala Ser Thr Pro Leu Gly 
    130                 135                 140                 


Pro Val Asp Phe Gly Asn Val Val Ala Thr Leu Asp Pro Arg Ala Ala 
145                 150                 155                 160 


Arg His Leu Thr Leu Ala Cys His Tyr Asp Ser Lys Leu Phe Pro Pro 
                165                 170                 175     


Gly Ser Thr Pro Phe Val Gly Ala Thr Asp Ser Ala Val Pro Cys Ala 
            180                 185                 190         


Leu Leu Leu Glu Leu Ala Gln Ala Leu Asp Leu Glu Leu Ser Arg Ala 
        195                 200                 205             


Lys Lys Gln Ala Ala Pro Val Thr Leu Gln Leu Leu Phe Leu Asp Gly 
    210                 215                 220                 


Glu Glu Ala Leu Lys Glu Trp Gly Pro Lys Asp Ser Leu Tyr Gly Ser 
225                 230                 235                 240 


Arg His Leu Ala Gln Leu Met Glu Ser Ile Pro His Ser Pro Gly Pro 
                245                 250                 255     


Thr Arg Ile Gln Ala Ile Glu Leu Phe Met Leu Leu Asp Leu Leu Gly 
            260                 265                 270         


Ala Pro Asn Pro Thr Phe Tyr Ser His Phe Pro Arg Thr Val Arg Trp 
        275                 280                 285             


Phe His Arg Leu Arg Ser Ile Glu Lys Arg Leu His Arg Leu Asn Leu 
    290                 295                 300                 


Leu Gln Ser His Pro Gln Glu Val Met Tyr Phe Gln Pro Gly Glu Pro 
305                 310                 315                 320 


Phe Gly Ser Val Glu Asp Asp His Ile Pro Phe Leu Arg Arg Gly Val 
                325                 330                 335     


Pro Val Leu His Leu Ile Ser Thr Pro Phe Pro Ala Val Trp His Thr 
            340                 345                 350         


Pro Ala Asp Thr Glu Val Asn Leu His Pro Pro Thr Val His Asn Leu 
        355                 360                 365             


Cys Arg Ile Leu Ala Val Phe Leu Ala Glu Tyr Leu Gly Leu 
    370                 375                 380         


<210>  4319
<211>  2022
<212>  PRT
<213>  Homo sapiens

<400>  4319

Met Lys Glu Gln Pro Val Leu Glu Arg Leu Gln Ser Gln Lys Ser Trp 
1               5                   10                  15      


Ile Lys Gly Val Phe Asp Lys Arg Glu Cys Ser Thr Ile Ile Pro Ser 
            20                  25                  30          


Ser Lys Asn Pro His Arg Cys Thr Pro Val Cys Gln Val Cys Gln Asn 
        35                  40                  45              


Leu Ile Arg Cys Tyr Cys Gly Arg Leu Ile Gly Asp His Ala Gly Ile 
    50                  55                  60                  


Asp Tyr Ser Trp Thr Ile Ser Ala Ala Lys Gly Lys Glu Ser Glu Gln 
65                  70                  75                  80  


Trp Ser Val Glu Lys His Thr Thr Lys Ser Pro Thr Asp Thr Phe Gly 
                85                  90                  95      


Thr Ile Asn Phe Gln Asp Gly Glu His Thr His His Ala Lys Tyr Ile 
            100                 105                 110         


Arg Thr Ser Tyr Asp Thr Lys Leu Asp His Leu Leu His Leu Met Leu 
        115                 120                 125             


Lys Glu Trp Lys Met Glu Leu Pro Lys Leu Val Ile Ser Val His Gly 
    130                 135                 140                 


Gly Ile Gln Asn Phe Thr Met Pro Ser Lys Phe Lys Glu Ile Phe Ser 
145                 150                 155                 160 


Gln Gly Leu Val Lys Ala Ala Glu Thr Thr Gly Ala Trp Ile Ile Thr 
                165                 170                 175     


Glu Gly Ile Asn Thr Gly Val Ser Lys His Val Gly Asp Ala Leu Lys 
            180                 185                 190         


Ser His Ser Ser His Ser Leu Arg Lys Ile Trp Thr Val Gly Ile Pro 
        195                 200                 205             


Pro Trp Gly Val Ile Glu Asn Gln Arg Asp Leu Ile Gly Lys Asp Val 
    210                 215                 220                 


Val Cys Leu Tyr Gln Thr Leu Asp Asn Pro Leu Ser Lys Leu Thr Thr 
225                 230                 235                 240 


Leu Asn Ser Met His Ser His Phe Ile Leu Ser Asp Asp Gly Thr Val 
                245                 250                 255     


Gly Lys Tyr Gly Asn Glu Met Lys Leu Arg Arg Asn Leu Glu Lys Tyr 
            260                 265                 270         


Leu Ser Leu Gln Lys Ile His Cys Arg Ser Arg Gln Gly Val Pro Val 
        275                 280                 285             


Val Gly Leu Val Val Glu Gly Gly Pro Asn Val Ile Leu Ser Val Trp 
    290                 295                 300                 


Glu Thr Val Lys Asp Lys Asp Pro Val Val Val Cys Glu Gly Thr Gly 
305                 310                 315                 320 


Arg Ala Ala Asp Leu Leu Ala Phe Thr His Lys His Leu Ala Asp Glu 
                325                 330                 335     


Gly Met Leu Arg Pro Gln Val Lys Glu Glu Ile Ile Cys Met Ile Gln 
            340                 345                 350         


Asn Thr Phe Asn Phe Ser Leu Lys Gln Ser Lys His Leu Phe Gln Ile 
        355                 360                 365             


Leu Met Glu Cys Met Val His Arg Asp Cys Ile Thr Ile Phe Asp Ala 
    370                 375                 380                 


Asp Ser Glu Glu Gln Gln Asp Leu Asp Leu Ala Ile Leu Thr Ala Leu 
385                 390                 395                 400 


Leu Lys Gly Thr Asn Leu Ser Ala Ser Glu Gln Leu Asn Leu Ala Met 
                405                 410                 415     


Ala Trp Asp Arg Val Asp Ile Ala Lys Lys His Ile Leu Ile Tyr Glu 
            420                 425                 430         


Gln His Trp Lys Pro Asp Ala Leu Glu Gln Ala Met Ser Asp Ala Leu 
        435                 440                 445             


Val Met Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Tyr Gly Val 
    450                 455                 460                 


Asn Leu His Arg Phe Leu Thr Ile Pro Arg Leu Glu Glu Leu Tyr Asn 
465                 470                 475                 480 


Thr Lys Gln Gly Pro Thr Asn Thr Leu Leu His His Leu Val Gln Asp 
                485                 490                 495     


Val Lys Gln His Thr Leu Leu Ser Gly Tyr Arg Ile Thr Leu Ile Asp 
            500                 505                 510         


Ile Gly Leu Val Val Glu Tyr Leu Ile Gly Arg Ala Tyr Arg Ser Asn 
        515                 520                 525             


Tyr Thr Arg Lys His Phe Arg Ala Leu Tyr Asn Asn Leu Tyr Arg Lys 
    530                 535                 540                 


Tyr Lys His Gln Arg His Ser Ser Gly Asn Arg Asn Glu Ser Ala Glu 
545                 550                 555                 560 


Ser Thr Leu His Ser Gln Phe Ile Arg Thr Ala Gln Pro Tyr Lys Phe 
                565                 570                 575     


Lys Glu Lys Ser Ile Val Leu His Lys Ser Arg Lys Lys Ser Lys Glu 
            580                 585                 590         


Gln Asn Val Ser Asp Asp Pro Glu Ser Thr Gly Phe Leu Tyr Pro Tyr 
        595                 600                 605             


Asn Asp Leu Leu Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala 
    610                 615                 620                 


Met Phe Phe Trp Gln His Gly Glu Glu Ala Thr Val Lys Ala Val Ile 
625                 630                 635                 640 


Ala Cys Ile Leu Tyr Arg Ala Met Ala His Glu Ala Lys Glu Ser His 
                645                 650                 655     


Met Val Asp Asp Ala Ser Glu Glu Leu Lys Asn Tyr Ser Lys Gln Phe 
            660                 665                 670         


Gly Gln Leu Ala Leu Asp Leu Leu Glu Lys Ala Phe Lys Gln Asn Glu 
        675                 680                 685             


Arg Met Ala Met Thr Leu Leu Thr Tyr Glu Leu Arg Asn Trp Ser Asn 
    690                 695                 700                 


Ser Thr Cys Leu Lys Leu Ala Val Ser Gly Gly Leu Arg Pro Phe Val 
705                 710                 715                 720 


Ser His Thr Cys Thr Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg 
                725                 730                 735     


Leu Lys Met Arg Lys Asn Ser Trp Leu Lys Ile Ile Ile Ser Ile Ile 
            740                 745                 750         


Leu Pro Pro Thr Ile Leu Thr Leu Glu Phe Lys Ser Lys Ala Glu Met 
        755                 760                 765             


Ser His Val Pro Gln Ser Gln Asp Phe Gln Phe Met Trp Tyr Tyr Ser 
    770                 775                 780                 


Asp Gln Asn Ala Ser Ser Ser Lys Glu Ser Ala Ser Val Lys Glu Tyr 
785                 790                 795                 800 


Asp Leu Glu Arg Gly His Asp Glu Lys Leu Asp Glu Asn Gln His Phe 
                805                 810                 815     


Gly Leu Glu Ser Gly His Gln His Leu Pro Trp Thr Arg Lys Val Tyr 
            820                 825                 830         


Glu Phe Tyr Ser Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Met Ala 
        835                 840                 845             


Tyr Leu Ala Phe Leu Met Leu Phe Thr Tyr Thr Val Leu Val Glu Met 
    850                 855                 860                 


Gln Pro Gln Pro Ser Val Gln Glu Trp Leu Val Ser Ile Tyr Ile Phe 
865                 870                 875                 880 


Thr Asn Ala Ile Glu Val Val Arg Glu Ile Cys Ile Ser Glu Pro Gly 
                885                 890                 895     


Lys Phe Thr Gln Lys Val Lys Val Trp Ile Ser Glu Tyr Trp Asn Leu 
            900                 905                 910         


Thr Glu Thr Val Ala Ile Gly Leu Phe Ser Ala Gly Phe Val Leu Arg 
        915                 920                 925             


Trp Gly Asp Pro Pro Phe His Thr Ala Gly Arg Leu Ile Tyr Cys Ile 
    930                 935                 940                 


Asp Ile Ile Phe Trp Phe Ser Arg Leu Leu Asp Phe Phe Ala Val Asn 
945                 950                 955                 960 


Gln His Ala Gly Pro Tyr Val Thr Met Ile Ala Lys Met Thr Ala Asn 
                965                 970                 975     


Met Phe Tyr Ile Val Ile Ile Met Ala Ile Val Leu Leu Ser Phe Gly 
            980                 985                 990         


Val Ala Arg Lys Ala Ile Leu Ser  Pro Lys Glu Pro Pro  Ser Trp Ser 
        995                 1000                 1005             


Leu Ala  Arg Asp Ile Val Phe  Glu Pro Tyr Trp Met  Ile Tyr Gly 
    1010                 1015                 1020             


Glu Val  Tyr Ala Gly Glu Ile  Asp Val Cys Ser Ser  Gln Pro Ser 
    1025                 1030                 1035             


Cys Pro  Pro Gly Ser Phe Leu  Thr Pro Phe Leu Gln  Ala Val Tyr 
    1040                 1045                 1050             


Leu Phe  Val Gln Tyr Ile Ile  Met Val Asn Leu Leu  Ile Ala Phe 
    1055                 1060                 1065             


Phe Asn  Asn Val Tyr Leu Asp  Met Glu Ser Ile Ser  Asn Asn Leu 
    1070                 1075                 1080             


Trp Lys  Tyr Asn Arg Tyr Arg  Tyr Ile Met Thr Tyr  His Glu Lys 
    1085                 1090                 1095             


Pro Trp  Leu Pro Pro Pro Leu  Ile Leu Leu Ser His  Val Gly Leu 
    1100                 1105                 1110             


Leu Leu  Arg Arg Leu Cys Cys  His Arg Ala Pro His  Asp Gln Glu 
    1115                 1120                 1125             


Glu Gly  Asp Val Gly Leu Lys  Leu Tyr Leu Ser Lys  Glu Asp Leu 
    1130                 1135                 1140             


Lys Lys  Leu His Asp Phe Glu  Glu Gln Cys Val Glu  Lys Tyr Phe 
    1145                 1150                 1155             


His Glu  Lys Met Glu Asp Val  Asn Cys Ser Cys Glu  Glu Arg Ile 
    1160                 1165                 1170             


Arg Val  Thr Ser Glu Arg Val  Thr Glu Met Tyr Phe  Gln Leu Lys 
    1175                 1180                 1185             


Glu Met  Asn Glu Lys Val Ser  Phe Ile Lys Asp Ser  Leu Leu Ser 
    1190                 1195                 1200             


Leu Asp  Ser Gln Val Gly His  Leu Gln Asp Leu Ser  Ala Leu Thr 
    1205                 1210                 1215             


Val Asp  Thr Leu Lys Val Leu  Ser Ala Val Asp Thr  Leu Gln Glu 
    1220                 1225                 1230             


Asp Glu  Ala Leu Leu Ala Lys  Arg Lys His Ser Thr  Cys Lys Lys 
    1235                 1240                 1245             


Leu Pro  His Ser Trp Ser Asn  Val Ile Cys Ala Glu  Val Leu Gly 
    1250                 1255                 1260             


Ser Met  Glu Ile Ala Gly Glu  Lys Lys Tyr Gln Tyr  Tyr Ser Met 
    1265                 1270                 1275             


Pro Ser  Ser Leu Leu Arg Ser  Leu Ala Gly Gly Arg  His Pro Pro 
    1280                 1285                 1290             


Arg Val  Gln Arg Gly Ala Leu  Leu Glu Ile Thr Asn  Ser Lys Arg 
    1295                 1300                 1305             


Glu Ala  Thr Asn Val Arg Asn  Asp Gln Glu Arg Gln  Glu Thr Gln 
    1310                 1315                 1320             


Ser Ser  Ile Val Val Ser Gly  Val Ser Pro Asn Arg  Gln Ala His 
    1325                 1330                 1335             


Ser Lys  Tyr Gly Gln Phe Leu  Leu Val Pro Ser Asn  Leu Lys Arg 
    1340                 1345                 1350             


Val Pro  Phe Ser Ala Glu Thr  Val Leu Pro Leu Ser  Arg Pro Ser 
    1355                 1360                 1365             


Val Pro  Asp Val Leu Ala Thr  Glu Gln Asp Ile Gln  Thr Glu Val 
    1370                 1375                 1380             


Leu Val  His Leu Thr Gly Gln  Thr Pro Val Val Ser  Asp Trp Ala 
    1385                 1390                 1395             


Ser Val  Asp Glu Pro Lys Glu  Lys His Glu Pro Ile  Ala His Leu 
    1400                 1405                 1410             


Leu Asp  Gly Gln Asp Lys Ala  Glu Gln Val Leu Pro  Thr Leu Ser 
    1415                 1420                 1425             


Cys Thr  Pro Glu Pro Met Thr  Met Ser Ser Pro Leu  Ser Gln Ala 
    1430                 1435                 1440             


Lys Ile  Met Gln Thr Gly Gly  Gly Tyr Val Asn Trp  Ala Phe Ser 
    1445                 1450                 1455             


Glu Gly  Asp Glu Thr Gly Val  Phe Ser Ile Lys Lys  Lys Trp Gln 
    1460                 1465                 1470             


Thr Cys  Leu Pro Ser Thr Cys  Asp Ser Asp Ser Ser  Arg Ser Glu 
    1475                 1480                 1485             


Gln His  Gln Lys Gln Ala Gln  Asp Ser Ser Leu Ser  Asp Asn Ser 
    1490                 1495                 1500             


Thr Arg  Ser Ala Gln Ser Ser  Glu Cys Ser Glu Val  Gly Pro Trp 
    1505                 1510                 1515             


Leu Gln  Pro Asn Thr Ser Phe  Trp Ile Asn Pro Leu  Arg Arg Tyr 
    1520                 1525                 1530             


Arg Pro  Phe Ala Arg Ser His  Ser Phe Arg Phe His  Lys Glu Glu 
    1535                 1540                 1545             


Lys Leu  Met Lys Ile Cys Lys  Ile Lys Asn Leu Ser  Gly Ser Ser 
    1550                 1555                 1560             


Glu Ile  Gly Gln Gly Ala Trp  Val Lys Ala Lys Met  Leu Thr Lys 
    1565                 1570                 1575             


Asp Arg  Arg Leu Ser Lys Lys  Lys Lys Asn Thr Gln  Gly Leu Gln 
    1580                 1585                 1590             


Val Pro  Ile Ile Thr Val Asn  Ala Cys Ser Gln Ser  Asp Gln Leu 
    1595                 1600                 1605             


Asn Pro  Glu Pro Gly Glu Asn  Ser Ile Ser Glu Glu  Glu Tyr Ser 
    1610                 1615                 1620             


Lys Asn  Trp Phe Thr Val Ser  Lys Phe Ser His Thr  Gly Val Glu 
    1625                 1630                 1635             


Pro Tyr  Ile His Gln Lys Met  Lys Thr Lys Glu Ile  Gly Gln Cys 
    1640                 1645                 1650             


Ala Ile  Gln Ile Ser Asp Tyr  Leu Lys Gln Ser Gln  Glu Asp Leu 
    1655                 1660                 1665             


Ser Lys  Asn Ser Leu Trp Asn  Ser Arg Ser Thr Asn  Leu Asn Arg 
    1670                 1675                 1680             


Asn Ser  Leu Leu Lys Ser Ser  Ile Gly Val Asp Lys  Ile Ser Ala 
    1685                 1690                 1695             


Ser Leu  Lys Ser Pro Gln Glu  Pro His His His Tyr  Ser Ala Ile 
    1700                 1705                 1710             


Glu Arg  Asn Asn Leu Met Arg  Leu Ser Gln Thr Ile  Pro Phe Thr 
    1715                 1720                 1725             


Pro Val  Gln Leu Phe Ala Gly  Glu Glu Ile Thr Val  Tyr Arg Leu 
    1730                 1735                 1740             


Glu Glu  Ser Ser Pro Leu Asn  Leu Asp Lys Ser Met  Ser Ser Trp 
    1745                 1750                 1755             


Ser Gln  Arg Gly Arg Ala Ala  Met Ile Gln Val Leu  Ser Arg Glu 
    1760                 1765                 1770             


Glu Met  Asp Gly Gly Leu Arg  Lys Ala Met Arg Val  Val Ser Thr 
    1775                 1780                 1785             


Trp Ser  Glu Asp Asp Ile Leu  Lys Pro Gly Gln Val  Phe Ile Val 
    1790                 1795                 1800             


Lys Ser  Phe Leu Pro Glu Val  Val Arg Thr Trp His  Lys Ile Phe 
    1805                 1810                 1815             


Gln Glu  Ser Thr Val Leu His  Leu Cys Leu Arg Glu  Ile Gln Gln 
    1820                 1825                 1830             


Gln Arg  Ala Ala Gln Lys Leu  Ile Tyr Thr Phe Asn  Gln Val Lys 
    1835                 1840                 1845             


Pro Gln  Thr Ile Pro Tyr Thr  Pro Arg Phe Leu Glu  Val Phe Leu 
    1850                 1855                 1860             


Ile Tyr  Cys His Ser Ala Asn  Gln Trp Leu Thr Ile  Glu Lys Tyr 
    1865                 1870                 1875             


Met Thr  Gly Glu Phe Arg Lys  Tyr Asn Asn Asn Asn  Gly Asp Glu 
    1880                 1885                 1890             


Ile Thr  Pro Thr Asn Thr Leu  Glu Glu Leu Met Leu  Ala Phe Ser 
    1895                 1900                 1905             


His Trp  Thr Tyr Glu Tyr Thr  Arg Gly Glu Leu Leu  Val Leu Asp 
    1910                 1915                 1920             


Leu Gln  Gly Val Gly Glu Asn  Leu Thr Asp Pro Ser  Val Ile Lys 
    1925                 1930                 1935             


Pro Glu  Val Lys Gln Ser Arg  Gly Met Val Phe Gly  Pro Ala Asn 
    1940                 1945                 1950             


Leu Gly  Glu Asp Ala Ile Arg  Asn Phe Ile Ala Lys  His His Cys 
    1955                 1960                 1965             


Asn Ser  Cys Cys Arg Lys Leu  Lys Leu Pro Asp Leu  Lys Arg Asn 
    1970                 1975                 1980             


Asp Tyr  Ser Pro Glu Arg Ile  Asn Ser Thr Phe Gly  Leu Glu Ile 
    1985                 1990                 1995             


Lys Ile  Glu Ser Ala Glu Glu  Pro Pro Ala Arg Glu  Thr Gly Arg 
    2000                 2005                 2010             


Asn Ser  Pro Glu Asp Asp Met  Gln Leu 
    2015                 2020         


<210>  4320
<211>  1865
<212>  PRT
<213>  Homo sapiens

<400>  4320

Met Ser Gln Lys Ser Trp Ile Glu Ser Thr Leu Thr Lys Arg Glu Cys 
1               5                   10                  15      


Val Tyr Ile Ile Pro Ser Ser Lys Asp Pro His Arg Cys Leu Pro Gly 
            20                  25                  30          


Cys Gln Ile Cys Gln Gln Leu Val Arg Cys Phe Cys Gly Arg Leu Val 
        35                  40                  45              


Lys Gln His Ala Cys Phe Thr Ala Ser Leu Ala Met Lys Tyr Ser Asp 
    50                  55                  60                  


Val Lys Leu Gly Asp His Phe Asn Gln Ala Ile Glu Glu Trp Ser Val 
65                  70                  75                  80  


Glu Lys His Thr Glu Gln Ser Pro Thr Asp Ala Tyr Gly Val Ile Asn 
                85                  90                  95      


Phe Gln Gly Gly Ser His Ser Tyr Arg Ala Lys Tyr Val Arg Leu Ser 
            100                 105                 110         


Tyr Asp Thr Lys Pro Glu Val Ile Leu Gln Leu Leu Leu Lys Glu Trp 
        115                 120                 125             


Gln Met Glu Leu Pro Lys Leu Val Ile Ser Val His Gly Gly Met Gln 
    130                 135                 140                 


Lys Phe Glu Leu His Pro Arg Ile Lys Gln Leu Leu Gly Lys Gly Leu 
145                 150                 155                 160 


Ile Lys Ala Ala Val Thr Thr Gly Ala Trp Ile Leu Thr Gly Gly Val 
                165                 170                 175     


Asn Thr Gly Val Ala Lys His Val Gly Asp Ala Leu Lys Glu His Ala 
            180                 185                 190         


Ser Arg Ser Ser Arg Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly 
        195                 200                 205             


Val Ile Glu Asn Arg Asn Asp Leu Val Gly Arg Asp Val Val Ala Pro 
    210                 215                 220                 


Tyr Gln Thr Leu Leu Asn Pro Leu Ser Lys Leu Asn Val Leu Asn Asn 
225                 230                 235                 240 


Leu His Ser His Phe Ile Leu Val Asp Asp Gly Thr Val Gly Lys Tyr 
                245                 250                 255     


Gly Ala Glu Val Arg Leu Arg Arg Glu Leu Glu Lys Thr Ile Asn Gln 
            260                 265                 270         


Gln Arg Ile His Ala Arg Ile Gly Gln Gly Val Pro Val Val Ala Leu 
        275                 280                 285             


Ile Phe Glu Gly Gly Pro Asn Val Ile Leu Thr Val Leu Glu Tyr Leu 
    290                 295                 300                 


Gln Glu Ser Pro Pro Val Pro Val Val Val Cys Glu Gly Thr Gly Arg 
305                 310                 315                 320 


Ala Ala Asp Leu Leu Ala Tyr Ile His Lys Gln Thr Glu Glu Gly Gly 
                325                 330                 335     


Asn Leu Pro Asp Ala Ala Glu Pro Asp Ile Ile Ser Thr Ile Lys Lys 
            340                 345                 350         


Thr Phe Asn Phe Gly Gln Asn Glu Ala Leu His Leu Phe Gln Thr Leu 
        355                 360                 365             


Met Glu Cys Met Lys Arg Lys Glu Leu Ile Thr Val Phe His Ile Gly 
    370                 375                 380                 


Ser Asp Glu His Gln Asp Ile Asp Val Ala Ile Leu Thr Ala Leu Leu 
385                 390                 395                 400 


Lys Gly Thr Asn Ala Ser Ala Phe Asp Gln Leu Ile Leu Thr Leu Ala 
                405                 410                 415     


Trp Asp Arg Val Asp Ile Ala Lys Asn His Val Phe Val Tyr Gly Gln 
            420                 425                 430         


Gln Trp Leu Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val 
        435                 440                 445             


Met Asp Arg Val Ala Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser 
    450                 455                 460                 


Met His Lys Phe Leu Thr Ile Pro Arg Leu Glu Glu Leu Tyr Asn Thr 
465                 470                 475                 480 


Lys Gln Gly Pro Thr Asn Pro Met Leu Phe His Leu Val Arg Asp Val 
                485                 490                 495     


Lys Gln Gly Asn Leu Pro Pro Gly Tyr Lys Ile Thr Leu Ile Asp Ile 
            500                 505                 510         


Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Thr Tyr Arg Cys Thr Tyr 
        515                 520                 525             


Thr Arg Lys Arg Phe Arg Leu Ile Tyr Asn Ser Leu Gly Gly Asn Asn 
    530                 535                 540                 


Arg Arg Ser Gly Arg Asn Thr Ser Ser Ser Thr Pro Gln Leu Arg Lys 
545                 550                 555                 560 


Ser His Glu Ser Phe Gly Asn Arg Ala Asp Lys Lys Glu Lys Met Arg 
                565                 570                 575     


His Asn His Phe Ile Lys Thr Ala Gln Pro Tyr Arg Pro Lys Ile Asp 
            580                 585                 590         


Thr Val Met Glu Glu Gly Lys Lys Lys Arg Thr Lys Asp Glu Ile Val 
        595                 600                 605             


Asp Ile Asp Asp Pro Glu Thr Lys Arg Phe Pro Tyr Pro Leu Asn Glu 
    610                 615                 620                 


Leu Leu Ile Trp Ala Cys Leu Met Lys Arg Gln Val Met Ala Arg Phe 
625                 630                 635                 640 


Leu Trp Gln His Gly Glu Glu Ser Met Ala Lys Ala Leu Val Ala Cys 
                645                 650                 655     


Lys Ile Tyr Arg Ser Met Ala Tyr Glu Ala Lys Gln Ser Asp Leu Val 
            660                 665                 670         


Asp Asp Thr Ser Glu Glu Leu Lys Gln Tyr Ser Asn Asp Phe Gly Gln 
        675                 680                 685             


Leu Ala Val Glu Leu Leu Glu Gln Ser Phe Arg Gln Asp Glu Thr Met 
    690                 695                 700                 


Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ser Thr 
705                 710                 715                 720 


Cys Leu Lys Leu Ala Val Ser Ser Arg Leu Arg Pro Phe Val Ala His 
                725                 730                 735     


Thr Cys Thr Gln Met Leu Leu Ser Asp Met Trp Met Gly Arg Leu Asn 
            740                 745                 750         


Met Arg Lys Asn Ser Trp Tyr Lys Val Ile Leu Ser Ile Leu Val Pro 
        755                 760                 765             


Pro Ala Ile Leu Leu Leu Glu Tyr Lys Thr Lys Ala Glu Met Ser His 
    770                 775                 780                 


Ile Pro Gln Ser Gln Asp Ala His Gln Met Thr Met Asp Asp Ser Glu 
785                 790                 795                 800 


Asn Asn Phe Gln Asn Ile Thr Glu Glu Ile Pro Met Glu Val Phe Lys 
                805                 810                 815     


Glu Val Arg Ile Leu Asp Ser Asn Glu Gly Lys Asn Glu Met Glu Ile 
            820                 825                 830         


Gln Met Lys Ser Lys Lys Leu Pro Ile Thr Arg Lys Phe Tyr Ala Phe 
        835                 840                 845             


Tyr His Ala Pro Ile Val Lys Phe Trp Phe Asn Thr Leu Ala Tyr Leu 
    850                 855                 860                 


Gly Phe Leu Met Leu Tyr Thr Phe Val Val Leu Val Gln Met Glu Gln 
865                 870                 875                 880 


Leu Pro Ser Val Gln Glu Trp Ile Val Ile Ala Tyr Ile Phe Thr Tyr 
                885                 890                 895     


Ala Ile Glu Lys Val Arg Glu Ile Phe Met Ser Glu Ala Gly Lys Val 
            900                 905                 910         


Asn Gln Lys Ile Lys Val Trp Phe Ser Asp Tyr Phe Asn Ile Ser Asp 
        915                 920                 925             


Thr Ile Ala Ile Ile Ser Phe Phe Ile Gly Phe Gly Leu Arg Phe Gly 
    930                 935                 940                 


Ala Lys Trp Asn Phe Ala Asn Ala Tyr Asp Asn His Val Phe Val Ala 
945                 950                 955                 960 


Gly Arg Leu Ile Tyr Cys Leu Asn Ile Ile Phe Trp Tyr Val Arg Leu 
                965                 970                 975     


Leu Asp Phe Leu Ala Val Asn Gln Gln Ala Gly Pro Tyr Val Met Met 
            980                 985                 990         


Ile Gly Lys Met Val Ala Asn Met  Phe Tyr Ile Val Val  Ile Met Ala 
        995                 1000                 1005             


Leu Val  Leu Leu Ser Phe Gly  Val Pro Arg Lys Ala  Ile Leu Tyr 
    1010                 1015                 1020             


Pro His  Glu Ala Pro Ser Trp  Thr Leu Ala Lys Asp  Ile Val Phe 
    1025                 1030                 1035             


His Pro  Tyr Trp Met Ile Phe  Gly Glu Val Tyr Ala  Tyr Glu Ile 
    1040                 1045                 1050             


Asp Val  Cys Ala Asn Asp Ser  Val Ile Pro Gln Ile  Cys Gly Pro 
    1055                 1060                 1065             


Gly Thr  Trp Leu Thr Pro Phe  Leu Gln Ala Val Tyr  Leu Phe Val 
    1070                 1075                 1080             


Gln Tyr  Ile Ile Met Val Asn  Leu Leu Ile Ala Phe  Phe Asn Asn 
    1085                 1090                 1095             


Val Tyr  Leu Gln Val Lys Ala  Ile Ser Asn Ile Val  Trp Lys Tyr 
    1100                 1105                 1110             


Gln Arg  Tyr His Phe Ile Met  Ala Tyr His Glu Lys  Pro Val Leu 
    1115                 1120                 1125             


Pro Pro  Pro Leu Ile Ile Leu  Ser His Ile Val Ser  Leu Phe Cys 
    1130                 1135                 1140             


Cys Ile  Cys Lys Arg Arg Lys  Lys Asp Lys Thr Ser  Asp Gly Pro 
    1145                 1150                 1155             


Lys Leu  Phe Leu Thr Glu Glu  Asp Gln Lys Lys Leu  His Asp Phe 
    1160                 1165                 1170             


Glu Glu  Gln Cys Val Glu Met  Tyr Phe Asn Glu Lys  Asp Asp Lys 
    1175                 1180                 1185             


Phe His  Ser Gly Ser Glu Glu  Arg Ile Arg Val Thr  Phe Glu Arg 
    1190                 1195                 1200             


Val Glu  Gln Met Cys Ile Gln  Ile Lys Glu Val Gly  Asp Arg Val 
    1205                 1210                 1215             


Asn Tyr  Ile Lys Arg Ser Leu  Gln Ser Leu Asp Ser  Gln Ile Gly 
    1220                 1225                 1230             


His Leu  Gln Asp Leu Ser Ala  Leu Thr Val Asp Thr  Leu Lys Thr 
    1235                 1240                 1245             


Leu Thr  Ala Gln Lys Ala Ser  Glu Ala Ser Lys Val  His Asn Glu 
    1250                 1255                 1260             


Ile Thr  Arg Glu Leu Ser Ile  Ser Lys His Leu Ala  Gln Asn Leu 
    1265                 1270                 1275             


Ile Asp  Asp Gly Pro Val Arg  Pro Ser Val Trp Lys  Lys His Gly 
    1280                 1285                 1290             


Val Val  Asn Thr Leu Ser Ser  Ser Leu Pro Gln Gly  Asp Leu Glu 
    1295                 1300                 1305             


Ser Asn  Asn Pro Phe His Cys  Asn Ile Leu Met Lys  Asp Asp Lys 
    1310                 1315                 1320             


Asp Pro  Gln Cys Asn Ile Phe  Gly Gln Asp Leu Pro  Ala Val Pro 
    1325                 1330                 1335             


Gln Arg  Lys Glu Phe Asn Phe  Pro Glu Ala Gly Ser  Ser Ser Gly 
    1340                 1345                 1350             


Ala Leu  Phe Pro Ser Ala Val  Ser Pro Pro Glu Leu  Arg Gln Arg 
    1355                 1360                 1365             


Leu His  Gly Val Glu Leu Leu  Lys Ile Phe Asn Lys  Asn Gln Lys 
    1370                 1375                 1380             


Leu Gly  Ser Ser Ser Thr Ser  Ile Pro His Leu Ser  Ser Pro Pro 
    1385                 1390                 1395             


Thr Lys  Phe Phe Val Ser Thr  Pro Ser Gln Pro Ser  Cys Lys Ser 
    1400                 1405                 1410             


His Leu  Glu Thr Gly Thr Lys  Asp Gln Glu Thr Val  Cys Ser Lys 
    1415                 1420                 1425             


Ala Thr  Glu Gly Asp Asn Thr  Glu Phe Gly Ala Phe  Val Gly His 
    1430                 1435                 1440             


Arg Asp  Ser Met Asp Leu Gln  Arg Phe Lys Glu Thr  Ser Asn Lys 
    1445                 1450                 1455             


Ile Lys  Ile Leu Ser Asn Asn  Asn Thr Ser Glu Asn  Thr Leu Lys 
    1460                 1465                 1470             


Arg Val  Ser Ser Leu Ala Gly  Phe Thr Asp Cys His  Arg Thr Ser 
    1475                 1480                 1485             


Ile Pro  Val His Ser Lys Gln  Ala Glu Lys Ile Ser  Arg Arg Pro 
    1490                 1495                 1500             


Ser Thr  Glu Asp Thr His Glu  Val Asp Ser Lys Ala  Ala Leu Ile 
    1505                 1510                 1515             


Pro Asp  Trp Leu Gln Asp Arg  Pro Ser Asn Arg Glu  Met Pro Ser 
    1520                 1525                 1530             


Glu Glu  Gly Thr Leu Asn Gly  Leu Thr Ser Pro Phe  Lys Pro Ala 
    1535                 1540                 1545             


Met Asp  Thr Asn Tyr Tyr Tyr  Ser Ala Val Glu Arg  Asn Asn Leu 
    1550                 1555                 1560             


Met Arg  Leu Ser Gln Ser Ile  Pro Phe Thr Pro Val  Pro Pro Arg 
    1565                 1570                 1575             


Gly Glu  Pro Val Thr Val Tyr  Arg Leu Glu Glu Ser  Ser Pro Asn 
    1580                 1585                 1590             


Ile Leu  Asn Asn Ser Met Ser  Ser Trp Ser Gln Leu  Gly Leu Cys 
    1595                 1600                 1605             


Ala Lys  Ile Glu Phe Leu Ser  Lys Glu Glu Met Gly  Gly Gly Leu 
    1610                 1615                 1620             


Arg Arg  Ala Val Lys Val Gln  Cys Thr Trp Ser Glu  His Asp Ile 
    1625                 1630                 1635             


Leu Lys  Ser Gly His Leu Tyr  Ile Ile Lys Ser Phe  Leu Pro Glu 
    1640                 1645                 1650             


Val Val  Asn Thr Trp Ser Ser  Ile Tyr Lys Glu Asp  Thr Val Leu 
    1655                 1660                 1665             


His Leu  Cys Leu Arg Glu Ile  Gln Gln Gln Arg Ala  Ala Gln Lys 
    1670                 1675                 1680             


Leu Thr  Phe Ala Phe Asn Gln  Met Lys Pro Lys Ser  Ile Pro Tyr 
    1685                 1690                 1695             


Ser Pro  Arg Phe Leu Glu Val  Phe Leu Leu Tyr Cys  His Ser Ala 
    1700                 1705                 1710             


Gly Gln  Trp Phe Ala Val Glu  Glu Cys Met Thr Gly  Glu Phe Arg 
    1715                 1720                 1725             


Lys Tyr  Asn Asn Asn Asn Gly  Asp Glu Ile Ile Pro  Thr Asn Thr 
    1730                 1735                 1740             


Leu Glu  Glu Ile Met Leu Ala  Phe Ser His Trp Thr  Tyr Glu Tyr 
    1745                 1750                 1755             


Thr Arg  Gly Glu Leu Leu Val  Leu Asp Leu Gln Gly  Val Gly Glu 
    1760                 1765                 1770             


Asn Leu  Thr Asp Pro Ser Val  Ile Lys Ala Glu Glu  Lys Arg Ser 
    1775                 1780                 1785             


Cys Asp  Met Val Phe Gly Pro  Ala Asn Leu Gly Glu  Asp Ala Ile 
    1790                 1795                 1800             


Lys Asn  Phe Arg Ala Lys His  His Cys Asn Ser Cys  Cys Arg Lys 
    1805                 1810                 1815             


Leu Lys  Leu Pro Asp Leu Lys  Arg Asn Asp Tyr Thr  Pro Asp Lys 
    1820                 1825                 1830             


Ile Ile  Phe Pro Gln Asp Glu  Pro Ser Asp Leu Asn  Leu Gln Pro 
    1835                 1840                 1845             


Gly Asn  Ser Thr Lys Glu Ser  Glu Ser Thr Asn Ser  Val Arg Leu 
    1850                 1855                 1860             


Met Leu  
    1865 


<210>  4321
<211>  1310
<212>  PRT
<213>  Homo sapiens

<400>  4321

Met Ala Gln Leu Trp Leu Ser Cys Phe Leu Leu Pro Ala Leu Val Val 
1               5                   10                  15      


Ser Val Ala Ala Asn Val Ala Pro Lys Phe Leu Ala Asn Met Thr Ser 
            20                  25                  30          


Val Ile Leu Pro Glu Asp Leu Pro Val Gly Ala Gln Ala Phe Trp Leu 
        35                  40                  45              


Val Ala Glu Asp Gln Asp Asn Asp Pro Leu Thr Tyr Gly Met Ser Gly 
    50                  55                  60                  


Pro Asn Ala Tyr Phe Phe Ala Val Thr Pro Lys Thr Gly Glu Val Lys 
65                  70                  75                  80  


Leu Ala Ser Ala Leu Asp Tyr Glu Thr Leu Tyr Thr Phe Lys Val Thr 
                85                  90                  95      


Ile Ser Val Ser Asp Pro Tyr Ile Gln Val Gln Arg Glu Met Leu Val 
            100                 105                 110         


Ile Val Glu Asp Arg Asn Asp Asn Ala Pro Val Phe Gln Asn Thr Ala 
        115                 120                 125             


Phe Ser Thr Ser Ile Asn Glu Thr Leu Pro Val Gly Ser Val Val Phe 
    130                 135                 140                 


Ser Val Leu Ala Val Asp Lys Asp Met Gly Ser Ala Gly Met Val Val 
145                 150                 155                 160 


Tyr Ser Ile Glu Lys Val Ile Pro Ser Thr Gly Asp Ser Glu His Leu 
                165                 170                 175     


Phe Arg Ile Leu Ala Asn Gly Ser Ile Val Leu Asn Gly Ser Leu Ser 
            180                 185                 190         


Tyr Asn Asn Lys Ser Ala Phe Tyr Gln Leu Glu Leu Lys Ala Cys Asp 
        195                 200                 205             


Leu Gly Gly Met Tyr His Asn Thr Phe Thr Ile Gln Cys Ser Leu Pro 
    210                 215                 220                 


Val Phe Leu Ser Ile Ser Val Val Asp Gln Pro Asp Leu Asp Pro Gln 
225                 230                 235                 240 


Phe Val Arg Glu Phe Tyr Ser Ala Ser Val Ala Glu Asp Ala Ala Lys 
                245                 250                 255     


Gly Thr Ser Val Leu Thr Val Glu Ala Val Asp Gly Asp Lys Gly Ile 
            260                 265                 270         


Asn Asp Pro Val Ile Tyr Ser Ile Ser Tyr Ser Thr Arg Pro Gly Trp 
        275                 280                 285             


Phe Asp Ile Gly Ala Asp Gly Val Ile Arg Val Asn Gly Ser Leu Asp 
    290                 295                 300                 


Arg Glu Gln Leu Leu Glu Ala Asp Glu Glu Val Gln Leu Gln Val Thr 
305                 310                 315                 320 


Ala Thr Glu Thr His Leu Asn Ile Tyr Gly Gln Glu Ala Lys Val Ser 
                325                 330                 335     


Ile Trp Val Thr Val Arg Val Met Asp Val Asn Asp His Lys Pro Glu 
            340                 345                 350         


Phe Tyr Asn Cys Ser Leu Pro Ala Cys Thr Phe Thr Pro Glu Glu Ala 
        355                 360                 365             


Gln Val Asn Phe Thr Gly Tyr Val Asp Glu His Ala Ser Pro Arg Ile 
    370                 375                 380                 


Pro Ile Asp Asp Leu Thr Met Val Val Tyr Asp Pro Asp Lys Gly Ser 
385                 390                 395                 400 


Asn Gly Thr Phe Leu Leu Ser Leu Gly Gly Pro Asp Ala Glu Ala Phe 
                405                 410                 415     


Ser Val Ser Pro Glu Arg Ala Val Gly Ser Ala Ser Val Gln Val Leu 
            420                 425                 430         


Val Arg Val Ser Ala Leu Val Asp Tyr Glu Arg Gln Thr Ala Met Ala 
        435                 440                 445             


Val Gln Val Val Ala Thr Asp Ser Val Ser Gln Asn Phe Ser Val Ala 
    450                 455                 460                 


Met Val Thr Ile His Leu Arg Asp Ile Asn Asp His Arg Pro Thr Phe 
465                 470                 475                 480 


Pro Gln Ser Leu Tyr Val Leu Thr Val Pro Glu His Ser Ala Thr Gly 
                485                 490                 495     


Ser Val Val Thr Asp Ser Ile His Ala Thr Asp Pro Asp Thr Gly Ala 
            500                 505                 510         


Trp Gly Gln Ile Thr Tyr Ser Leu Leu Pro Gly Asn Gly Ala Asp Leu 
        515                 520                 525             


Phe Gln Val Asp Pro Val Ser Gly Thr Val Thr Val Arg Asn Gly Glu 
    530                 535                 540                 


Leu Leu Asp Arg Glu Ser Gln Ala Val Tyr Tyr Leu Thr Leu Gln Ala 
545                 550                 555                 560 


Thr Asp Gly Gly Asn Leu Ser Ser Ser Thr Thr Leu Gln Ile His Leu 
                565                 570                 575     


Leu Asp Ile Asn Asp Asn Ala Pro Val Val Ser Gly Ser Tyr Asn Ile 
            580                 585                 590         


Phe Val Gln Glu Glu Glu Gly Asn Val Ser Val Thr Ile Gln Ala His 
        595                 600                 605             


Asp Asn Asp Glu Pro Gly Thr Asn Asn Ser Arg Leu Leu Phe Asn Leu 
    610                 615                 620                 


Leu Pro Gly Pro Tyr Ser His Asn Phe Ser Leu Asp Pro Asp Thr Gly 
625                 630                 635                 640 


Leu Leu Arg Asn Leu Gly Pro Leu Asp Arg Glu Ala Ile Asp Pro Ala 
                645                 650                 655     


Leu Glu Gly Arg Ile Val Leu Thr Val Leu Val Ser Asp Cys Gly Glu 
            660                 665                 670         


Pro Val Leu Gly Thr Lys Val Asn Val Thr Ile Thr Val Glu Asp Ile 
        675                 680                 685             


Asn Asp Asn Leu Pro Ile Phe Asn Gln Ser Ser Tyr Asn Phe Thr Val 
    690                 695                 700                 


Lys Glu Glu Asp Pro Gly Val Leu Val Gly Val Val Lys Ala Trp Asp 
705                 710                 715                 720 


Ala Asp Gln Thr Glu Ala Asn Asn Arg Ile Ser Phe Ser Leu Ser Gly 
                725                 730                 735     


Ser Gly Ala Asn Tyr Phe Met Ile Arg Gly Leu Val Leu Gly Ala Gly 
            740                 745                 750         


Trp Ala Glu Gly Tyr Leu Arg Leu Pro Pro Asp Val Ser Leu Asp Tyr 
        755                 760                 765             


Glu Thr Gln Pro Val Phe Asn Leu Thr Val Ser Ala Glu Asn Pro Asp 
    770                 775                 780                 


Pro Gln Gly Gly Glu Thr Ile Val Asp Val Cys Val Asn Val Lys Asp 
785                 790                 795                 800 


Val Asn Asp Asn Pro Pro Thr Leu Asp Val Ala Ser Leu Arg Gly Ile 
                805                 810                 815     


Arg Val Ala Glu Asn Gly Ser Gln His Gly Gln Val Ala Val Val Val 
            820                 825                 830         


Ala Ser Asp Val Asp Thr Ser Ala Gln Leu Glu Ile Gln Leu Val Asn 
        835                 840                 845             


Ile Leu Cys Thr Lys Ala Gly Val Asp Val Gly Ser Leu Cys Trp Gly 
    850                 855                 860                 


Trp Phe Ser Val Ala Ala Asn Gly Ser Val Tyr Ile Asn Gln Ser Lys 
865                 870                 875                 880 


Ala Ile Asp Tyr Glu Ala Cys Asp Leu Val Thr Leu Val Val Arg Ala 
                885                 890                 895     


Cys Asp Leu Ala Thr Asp Pro Gly Phe Gln Ala Tyr Ser Asn Asn Gly 
            900                 905                 910         


Ser Leu Leu Ile Thr Ile Glu Asp Val Asn Asp Asn Ala Pro Tyr Phe 
        915                 920                 925             


Leu Pro Glu Asn Lys Thr Phe Val Ile Ile Pro Glu Leu Val Leu Pro 
    930                 935                 940                 


Asn Arg Glu Val Ala Ser Val Arg Ala Arg Asp Asp Asp Ser Gly Asn 
945                 950                 955                 960 


Asn Gly Val Ile Leu Phe Ser Ile Leu Arg Val Asp Phe Ile Ser Lys 
                965                 970                 975     


Asp Gly Ala Thr Ile Pro Phe Gln Gly Val Phe Ser Ile Phe Thr Ser 
            980                 985                 990         


Ser Glu Ala Asp Val Phe Ala Gly  Ser Ile Gln Pro Val  Thr Ser Leu 
        995                 1000                 1005             


Asp Ser  Thr Leu Gln Gly Thr  Tyr Gln Val Thr Val  Gln Ala Arg 
    1010                 1015                 1020             


Asp Arg  Pro Ser Leu Gly Pro  Phe Leu Glu Ala Thr  Thr Thr Leu 
    1025                 1030                 1035             


Asn Leu  Phe Thr Val Asp Gln  Ser Tyr Arg Ser Arg  Leu Gln Phe 
    1040                 1045                 1050             


Ser Thr  Pro Lys Glu Glu Val  Gly Ala Asn Arg Gln  Ala Ile Asn 
    1055                 1060                 1065             


Ala Ala  Leu Thr Gln Ala Thr  Arg Thr Thr Val Tyr  Ile Val Asp 
    1070                 1075                 1080             


Ile Gln  Asp Ile Asp Ser Ala  Ala Arg Ala Arg Pro  His Ser Tyr 
    1085                 1090                 1095             


Leu Asp  Ala Tyr Phe Val Phe  Pro Asn Gly Ser Ala  Leu Thr Leu 
    1100                 1105                 1110             


Asp Glu  Leu Ser Val Met Ile  Arg Asn Asp Gln Asp  Ser Leu Thr 
    1115                 1120                 1125             


Gln Leu  Leu Gln Leu Gly Leu  Val Val Leu Gly Ser  Gln Glu Ser 
    1130                 1135                 1140             


Gln Glu  Ser Asp Leu Ser Lys  Gln Leu Ile Ser Val  Ile Ile Gly 
    1145                 1150                 1155             


Leu Gly  Val Ala Leu Leu Leu  Val Leu Val Ile Met  Thr Met Ala 
    1160                 1165                 1170             


Phe Val  Cys Val Arg Lys Ser  Tyr Asn Arg Lys Leu  Gln Ala Met 
    1175                 1180                 1185             


Lys Ala  Ala Lys Glu Ala Arg  Lys Thr Ala Ala Gly  Val Met Pro 
    1190                 1195                 1200             


Ser Ala  Pro Ala Ile Pro Gly  Thr Asn Met Tyr Asn  Thr Glu Arg 
    1205                 1210                 1215             


Ala Asn  Pro Met Leu Asn Leu  Pro Asn Lys Asp Leu  Gly Leu Glu 
    1220                 1225                 1230             


Tyr Leu  Ser Pro Ser Asn Asp  Leu Asp Ser Val Ser  Val Asn Ser 
    1235                 1240                 1245             


Leu Asp  Asp Asn Ser Val Asp  Val Asp Lys Asn Ser  Gln Glu Ile 
    1250                 1255                 1260             


Lys Glu  His Arg Pro Pro His  Thr Pro Pro Glu Pro  Asp Pro Glu 
    1265                 1270                 1275             


Pro Leu  Ser Val Val Leu Leu  Gly Arg Gln Ala Gly  Ala Ser Gly 
    1280                 1285                 1290             


Gln Leu  Glu Gly Pro Ser Tyr  Thr Asn Ala Gly Leu  Asp Thr Thr 
    1295                 1300                 1305             


Asp Leu  
    1310 


<210>  4322
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  4322

Met Glu Lys Phe Asn Thr Ile Ser Val Ser Lys Cys Asn Lys Glu Thr 
1               5                   10                  15      


Val Ala Met Lys Glu Lys Cys Lys Phe Gly Met Thr Ser Thr Ile Pro 
            20                  25                  30          


Ser Gly His Val Trp Arg Asn Thr Trp Asn Pro Val Ser Cys Ser Leu 
        35                  40                  45              


Ala Thr Val Lys Met Lys Glu Cys Leu Arg Gly Lys Leu Ile Tyr Leu 
    50                  55                  60                  


Met Gly Asp Ser Thr Ile Arg Gln Trp Met Glu Tyr Phe Lys Ala Ser 
65                  70                  75                  80  


Ile Asn Thr Leu Lys Ser Val Asp Leu His Glu Ser Gly Lys Leu Gln 
                85                  90                  95      


His Gln Leu Ala Val Asp Leu Asp Arg Asn Ile Asn Ile Gln Trp Gln 
            100                 105                 110         


Lys Tyr Cys Tyr Pro Leu Ile Gly Ser Met Thr Tyr Ser Val Lys Glu 
        115                 120                 125             


Met Glu Tyr Leu Thr Arg Ala Ile Asp Arg Thr Gly Gly Glu Lys Asn 
    130                 135                 140                 


Thr Val Ile Val Ile Ser Leu Gly Gln His Phe Arg Pro Phe Pro Ile 
145                 150                 155                 160 


Asp Val Phe Ile Arg Arg Ala Leu Asn Val His Lys Ala Ile Gln His 
                165                 170                 175     


Leu Leu Leu Arg Ser Pro Asp Thr Met Val Ile Ile Lys Thr Glu Asn 
            180                 185                 190         


Ile Arg Glu Met Tyr Asn Asp Ala Glu Arg Phe Ser Asp Phe His Gly 
        195                 200                 205             


Tyr Ile Gln Tyr Leu Ile Ile Lys Asp Ile Phe Gln Asp Leu Ser Val 
    210                 215                 220                 


Ser Ile Ile Asp Ala Trp Asp Ile Thr Ile Ala Tyr Gly Thr Asn Asn 
225                 230                 235                 240 


Val His Pro Pro Gln His Val Val Gly Asn Gln Ile Asn Ile Leu Leu 
                245                 250                 255     


Asn Tyr Ile Cys 
            260 


<210>  4323
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  4323

Met Thr Val Thr Tyr Thr Ala Arg Val Ala Asn Ala Arg Phe Gly Gly 
1               5                   10                  15      


Phe Ser Gln Leu Leu Leu Leu Trp Arg Gly Ser Ile Tyr Lys Leu Leu 
            20                  25                  30          


Trp Arg Glu Leu Leu Cys Phe Leu Gly Phe Tyr Met Ala Leu Ser Ala 
        35                  40                  45              


Ala Tyr Arg Phe Val Leu Thr Glu Gly Gln Lys Arg Tyr Phe Glu Lys 
    50                  55                  60                  


Leu Val Ile Tyr Cys Asp Gln Tyr Ala Ser Leu Ile Pro Val Ser Phe 
65                  70                  75                  80  


Val Leu Gly Phe Tyr Val Thr Leu Val Val Asn Arg Trp Trp Ser Gln 
                85                  90                  95      


Tyr Leu Cys Met Pro Leu Pro Asp Ala Leu Met Cys Val Val Ala Gly 
            100                 105                 110         


Thr Val His Gly Arg Asp Asp Arg Gly Arg Leu Tyr Arg Arg Thr Leu 
        115                 120                 125             


Met Arg Tyr Ala Gly Leu Ser Ala Val Leu Ile Leu Arg Ser Val Ser 
    130                 135                 140                 


Thr Ala Val Phe Lys Arg Phe Pro Thr Ile Asp His Val Val Glu Ala 
145                 150                 155                 160 


Gly Phe Met Thr Arg Glu Glu Arg Lys Lys Phe Glu Asn Leu Asn Ser 
                165                 170                 175     


Ser Tyr Asn Lys Tyr Trp Val Pro Cys Val Trp Phe Ser Asn Leu Ala 
            180                 185                 190         


Ala Gln Ala Arg Arg Glu Gly Arg Ile Arg Asp Asn Ser Ala Leu Lys 
        195                 200                 205             


Leu Leu Leu Glu Glu Leu Asn Val Phe Arg Gly Lys Cys Gly Met Leu 
    210                 215                 220                 


Phe His Tyr Asp Trp Ile Ser Val Pro Leu Val Tyr Thr Gln Val Val 
225                 230                 235                 240 


Thr Ile Ala Leu Tyr Ser Tyr Phe Leu Ala Cys Leu Ile Gly Arg Gln 
                245                 250                 255     


Phe Leu Asp Pro Ala Gln Gly Tyr Lys Asp His Asp Leu Asp Leu Cys 
            260                 265                 270         


Val Pro Ile Phe Thr Leu Leu Gln Phe Phe Phe Tyr Ala Gly Trp Leu 
        275                 280                 285             


Lys Val Ala Glu Gln Leu Ile Asn Pro Phe Gly Glu Asp Asp Asp Asp 
    290                 295                 300                 


Phe Glu Thr Asn Phe Leu Ile Asp Arg Asn Phe Gln Val Ser Met Leu 
305                 310                 315                 320 


Ala Val Asp Glu Met Tyr Asp Asp Leu Ala Val Leu Glu Lys Asp Leu 
                325                 330                 335     


Tyr Trp Asp Ala Ala Glu Ala Arg Ala Pro Tyr Thr Ala Ala Thr Val 
            340                 345                 350         


Phe Gln Leu Arg Gln Pro Ser Phe Gln Gly Ser Thr Phe Asp Ile Thr 
        355                 360                 365             


Leu Ala Lys Glu Asp Met Gln Phe Gln Arg Leu Asp Gly Leu Asp Gly 
    370                 375                 380                 


Pro Met Gly Glu Ala Pro Gly Asp Phe Leu Gln Arg Leu Leu Pro Ala 
385                 390                 395                 400 


Gly Ala Gly Met Val Ala Gly Gly Pro Leu Gly Arg Arg Leu Ser Phe 
                405                 410                 415     


Leu Leu Arg Lys Asn Ser Cys Val Ser Glu Ala Ser Thr Gly Ala Ser 
            420                 425                 430         


Cys Ser Cys Ala Val Val Pro Glu Gly Ala Ala Pro Glu Cys Ser Cys 
        435                 440                 445             


Gly Asp Pro Leu Leu Asp Pro Gly Leu Pro Glu Pro Glu Ala Pro Pro 
    450                 455                 460                 


Pro Ala Gly Pro Glu Pro Leu Thr Leu Ile Pro Gly Pro Val Glu Pro 
465                 470                 475                 480 


Phe Ser Ile Val Thr Met Pro Gly Pro Arg Gly Pro Ala Pro Pro Trp 
                485                 490                 495     


Leu Pro Ser Pro Ile Gly Glu Glu Glu Glu Asn Leu Ala 
            500                 505                 


<210>  4324
<211>  791
<212>  PRT
<213>  Homo sapiens

<400>  4324

Met Ala Asp Asp Lys Val Ala Ile Leu Thr Asp Asp Glu Glu Glu Gln 
1               5                   10                  15      


Lys Arg Lys Tyr Val Leu Ala Asp Pro Phe Asn Gly Ile Ser Arg Glu 
            20                  25                  30          


Pro Glu Pro Pro Ser Asn Glu Thr Pro Ser Ser Thr Glu Thr Ser Ala 
        35                  40                  45              


Ile Pro Glu Glu Glu Ile Asp Trp Ile Glu Lys His Cys Val Lys Ile 
    50                  55                  60                  


Asn Asn Asp Leu Leu Ile Ser Lys Val Phe Tyr Phe Phe Phe Tyr Ser 
65                  70                  75                  80  


Ala Tyr Gly Ser Leu Tyr Pro Leu Leu Pro Val Tyr Tyr Lys Gln Leu 
                85                  90                  95      


Gly Met Ser Pro Ser Gln Ser Gly Leu Leu Val Gly Ile Arg Tyr Phe 
            100                 105                 110         


Ile Glu Phe Cys Ser Ala Pro Phe Trp Gly Val Val Ala Asp Arg Phe 
        115                 120                 125             


Lys Lys Gly Lys Ile Val Leu Leu Phe Ser Leu Leu Cys Trp Val Leu 
    130                 135                 140                 


Phe Asn Leu Gly Ile Gly Phe Val Lys Pro Ala Thr Leu Arg Cys Val 
145                 150                 155                 160 


Pro Lys Ile Arg Pro Thr Thr His Pro Thr Asn Ala Ser His Gln Leu 
                165                 170                 175     


Thr Ile Leu Pro Thr Asn Ser Ser Phe Thr Ser Phe Leu Thr Ile Ser 
            180                 185                 190         


Pro Lys Met Arg Glu Lys Arg Asn Leu Leu Glu Thr Arg Leu Asn Val 
        195                 200                 205             


Ser Asp Thr Val Thr Leu Pro Thr Ala Pro Asn Met Asn Ser Glu Pro 
    210                 215                 220                 


Thr Leu Gln Pro Gln Thr Gly Glu Ile Thr Asn Arg Met Met Asp Leu 
225                 230                 235                 240 


Thr Leu Asn Ser Ser Thr Ala Thr Pro Val Ser Pro Gly Ser Val Thr 
                245                 250                 255     


Lys Glu Thr Thr Thr Val Ile Val Thr Thr Thr Lys Ser Leu Pro Ser 
            260                 265                 270         


Asp Gln Val Met Leu Val Tyr Asp Gln Gln Glu Val Glu Ala Ile Phe 
        275                 280                 285             


Leu Val Ile Leu Val Val Val Ile Ile Gly Glu Phe Phe Ser Ala Ser 
    290                 295                 300                 


Ser Val Thr Ile Val Asp Thr Val Thr Leu Gln Tyr Leu Gly Lys His 
305                 310                 315                 320 


Arg Asp Arg Tyr Gly Leu Gln Arg Met Trp Gly Ser Leu Gly Trp Gly 
                325                 330                 335     


Leu Ala Met Leu Ser Val Gly Ile Gly Ile Asp Tyr Thr His Ile Glu 
            340                 345                 350         


Val Leu Ile Asp Gly Lys Gly Cys Lys Pro Pro Glu Tyr Arg Asn Tyr 
        355                 360                 365             


Gln Ile Val Phe Ile Val Phe Gly Val Leu Met Thr Met Ala Leu Ile 
    370                 375                 380                 


Val Ala Thr Gln Phe Arg Phe Arg Tyr Asn His Phe Lys Asn Asp Asp 
385                 390                 395                 400 


Ser Lys Gly Lys Glu Val Glu Ile Pro Gln Val Glu Arg Asn Asn Ser 
                405                 410                 415     


Thr Glu Ser Ser Glu Glu Thr Pro Thr Thr Thr Ser His Ser Gln Ala 
            420                 425                 430         


Phe Asn Phe Trp Asp Leu Ile Lys Leu Leu Cys Ser Val Gln Tyr Gly 
        435                 440                 445             


Ser Val Leu Phe Val Ala Trp Phe Met Gly Phe Gly Tyr Gly Phe Val 
    450                 455                 460                 


Phe Thr Phe Leu Tyr Trp His Leu Glu Asp Leu Asn Gly Thr Thr Thr 
465                 470                 475                 480 


Leu Phe Gly Val Cys Ser Val Leu Ser His Val Ser Glu Leu Thr Ala 
                485                 490                 495     


Tyr Phe Phe Ser His Lys Leu Ile Glu Leu Ile Gly His Ile Arg Val 
            500                 505                 510         


Leu Tyr Ile Gly Leu Ala Cys Asn Thr Ala Arg Tyr Ile Tyr Ile Ser 
        515                 520                 525             


Tyr Leu Glu Asn Ala Trp Thr Val Leu Pro Met Glu Val Leu Gln Gly 
    530                 535                 540                 


Val Thr His Ala Ala Ile Trp Ala Ala Cys Ile Ser Tyr Leu Ser Ala 
545                 550                 555                 560 


Ala Val Pro Pro Glu Leu Arg Thr Ser Ala Gln Gly Ile Leu Gln Gly 
                565                 570                 575     


Leu His Leu Gly Leu Gly Arg Gly Cys Gly Ala Met Ile Gly Gly Val 
            580                 585                 590         


Leu Val Asn Tyr Phe Gly Ala Ala Ala Thr Phe Arg Gly Ile Gly Met 
        595                 600                 605             


Ala Cys Leu Val Ile Leu Leu Leu Phe Ala Leu Ile Gln Trp Leu Ala 
    610                 615                 620                 


Val Pro Asp Glu Glu Glu Asp Lys Thr Met Leu Ala Glu Arg Ile Pro 
625                 630                 635                 640 


Val Pro Ser Ser Pro Val Pro Ile Ala Thr Ile Asp Leu Val Gln Gln 
                645                 650                 655     


Gln Thr Glu Asp Val Met Pro Arg Ile Glu Pro Arg Leu Pro Pro Lys 
            660                 665                 670         


Lys Thr Lys His Gln Glu Glu Gln Glu Asp Val Asn Lys Pro Ala Trp 
        675                 680                 685             


Gly Val Ser Ser Ser Pro Trp Val Thr Phe Val Tyr Ala Leu Tyr Gln 
    690                 695                 700                 


Ile Lys Glu Met Met Gln Leu Thr Arg Asp Asn Arg Ala Ser Glu Ile 
705                 710                 715                 720 


Gln Pro Leu Gln Gly Thr Asn Glu Asn Arg Glu Asn Ser Pro Ala Gly 
                725                 730                 735     


Arg Ala Gln Pro Val Pro Cys Glu Thr His Ser Asp Pro Ser Arg Asn 
            740                 745                 750         


Gln Pro Ser Pro Asp Ala Ala Ala Ser Gln Thr Gln Thr Ser Pro Ala 
        755                 760                 765             


His Pro Ser Val Asp Pro Cys Thr Glu Glu Ser Glu Glu Gln Gln Ala 
    770                 775                 780                 


Gln Leu Ala Ala Gly Gly His 
785                 790     


<210>  4325
<211>  827
<212>  PRT
<213>  Homo sapiens

<400>  4325

Met Arg Gly Cys Leu Arg Leu Ala Leu Leu Cys Ala Leu Pro Trp Leu 
1               5                   10                  15      


Leu Leu Ala Ala Ser Pro Gly His Pro Ala Lys Ser Pro Arg Gln Pro 
            20                  25                  30          


Pro Ala Pro Arg Arg Asp Pro Phe Asp Ala Ala Arg Gly Ala Asp Phe 
        35                  40                  45              


Asp His Val Tyr Ser Gly Val Val Asn Leu Ser Thr Glu Asn Ile Tyr 
    50                  55                  60                  


Ser Phe Asn Tyr Thr Ser Gln Pro Asp Gln Val Thr Ala Val Arg Val 
65                  70                  75                  80  


Tyr Val Asn Ser Ser Ser Glu Asn Leu Asn Tyr Pro Val Leu Val Val 
                85                  90                  95      


Val Arg Gln Gln Lys Glu Val Leu Ser Trp Gln Val Pro Leu Leu Phe 
            100                 105                 110         


Gln Gly Leu Tyr Gln Arg Ser Tyr Asn Tyr Gln Glu Val Ser Arg Thr 
        115                 120                 125             


Leu Cys Pro Ser Glu Ala Thr Asn Glu Thr Gly Pro Leu Gln Gln Leu 
    130                 135                 140                 


Ile Phe Val Asp Val Ala Ser Met Ala Pro Leu Gly Ala Gln Tyr Lys 
145                 150                 155                 160 


Leu Leu Val Thr Lys Leu Lys His Phe Gln Leu Arg Thr Asn Val Ala 
                165                 170                 175     


Phe His Phe Thr Ala Ser Pro Ser Gln Pro Gln Tyr Phe Leu Tyr Lys 
            180                 185                 190         


Phe Pro Lys Asp Val Asp Ser Val Ile Ile Lys Val Val Ser Glu Met 
        195                 200                 205             


Ala Tyr Pro Cys Ser Val Val Ser Val Gln Asn Ile Met Cys Pro Val 
    210                 215                 220                 


Tyr Asp Leu Asp His Asn Val Glu Phe Asn Gly Val Tyr Gln Ser Met 
225                 230                 235                 240 


Thr Lys Lys Ala Ala Ile Thr Leu Gln Lys Lys Asp Phe Pro Gly Glu 
                245                 250                 255     


Gln Phe Phe Val Val Phe Val Ile Lys Pro Glu Asp Tyr Ala Cys Gly 
            260                 265                 270         


Gly Ser Phe Phe Ile Gln Glu Lys Glu Asn Gln Thr Trp Asn Leu Gln 
        275                 280                 285             


Arg Lys Lys Asn Leu Glu Val Thr Ile Val Pro Ser Ile Lys Glu Ser 
    290                 295                 300                 


Val Tyr Val Lys Ser Ser Leu Phe Ser Val Phe Ile Phe Leu Ser Phe 
305                 310                 315                 320 


Tyr Leu Gly Cys Leu Leu Val Gly Phe Val His Tyr Leu Arg Phe Gln 
                325                 330                 335     


Arg Lys Ser Ile Asp Gly Ser Phe Gly Ser Asn Asp Gly Ser Gly Asn 
            340                 345                 350         


Met Val Ala Ser His Pro Ile Ala Ala Ser Thr Pro Glu Gly Ser Asn 
        355                 360                 365             


Tyr Gly Thr Ile Asp Glu Ser Ser Ser Ser Pro Gly Arg Gln Met Ser 
    370                 375                 380                 


Ser Ser Asp Gly Gly Pro Pro Gly Gln Ser Asp Thr Asp Ser Ser Val 
385                 390                 395                 400 


Glu Glu Ser Asp Phe Asp Thr Met Pro Asp Ile Glu Ser Asp Lys Asn 
                405                 410                 415     


Ile Ile Arg Thr Lys Met Phe Leu Tyr Leu Ser Asp Leu Ser Arg Lys 
            420                 425                 430         


Asp Arg Arg Ile Val Ser Lys Lys Tyr Lys Ile Tyr Phe Trp Asn Ile 
        435                 440                 445             


Ile Thr Ile Ala Val Phe Tyr Ala Leu Pro Val Ile Gln Leu Val Ile 
    450                 455                 460                 


Thr Tyr Gln Thr Val Val Asn Val Thr Gly Asn Gln Asp Ile Cys Tyr 
465                 470                 475                 480 


Tyr Asn Phe Leu Cys Ala His Pro Leu Gly Val Leu Ser Ala Phe Asn 
                485                 490                 495     


Asn Ile Leu Ser Asn Leu Gly His Val Leu Leu Gly Phe Leu Phe Leu 
            500                 505                 510         


Leu Ile Val Leu Arg Arg Asp Ile Leu His Arg Arg Ala Leu Glu Ala 
        515                 520                 525             


Lys Asp Ile Phe Ala Val Glu Tyr Gly Ile Pro Lys His Phe Gly Leu 
    530                 535                 540                 


Phe Tyr Ala Met Gly Ile Ala Leu Met Met Glu Gly Val Leu Ser Ala 
545                 550                 555                 560 


Cys Tyr His Val Cys Pro Asn Tyr Ser Asn Phe Gln Phe Asp Thr Ser 
                565                 570                 575     


Phe Met Tyr Met Ile Ala Gly Leu Cys Met Leu Lys Leu Tyr Gln Thr 
            580                 585                 590         


Arg His Pro Asp Ile Asn Ala Ser Ala Tyr Ser Ala Tyr Ala Ser Phe 
        595                 600                 605             


Ala Val Val Ile Met Val Thr Val Leu Gly Val Val Phe Gly Lys Asn 
    610                 615                 620                 


Asp Val Trp Phe Trp Val Ile Phe Ser Ala Ile His Val Leu Ala Ser 
625                 630                 635                 640 


Leu Ala Leu Ser Thr Gln Ile Tyr Tyr Met Gly Arg Phe Lys Ile Asp 
                645                 650                 655     


Leu Gly Ile Phe Arg Arg Ala Ala Met Val Phe Tyr Thr Asp Cys Ile 
            660                 665                 670         


Gln Gln Cys Ser Arg Pro Leu Tyr Met Asp Arg Met Val Leu Leu Val 
        675                 680                 685             


Val Gly Asn Leu Val Asn Trp Ser Phe Ala Leu Phe Gly Leu Ile Tyr 
    690                 695                 700                 


Arg Pro Arg Asp Phe Ala Ser Tyr Met Leu Gly Ile Phe Ile Cys Asn 
705                 710                 715                 720 


Leu Leu Leu Tyr Leu Ala Phe Tyr Ile Ile Met Lys Leu Arg Ser Ser 
                725                 730                 735     


Glu Lys Val Leu Pro Val Pro Leu Phe Cys Ile Val Ala Thr Ala Val 
            740                 745                 750         


Met Trp Ala Ala Ala Leu Tyr Phe Phe Phe Gln Asn Leu Ser Ser Trp 
        755                 760                 765             


Glu Gly Thr Pro Ala Glu Ser Arg Glu Lys Asn Arg Glu Cys Ile Leu 
    770                 775                 780                 


Leu Asp Phe Phe Asp Asp His Asp Ile Trp His Phe Leu Ser Ala Thr 
785                 790                 795                 800 


Ala Leu Phe Phe Ser Phe Leu Val Leu Leu Thr Leu Asp Asp Asp Leu 
                805                 810                 815     


Asp Val Val Arg Arg Asp Gln Ile Pro Val Phe 
            820                 825         


<210>  4326
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  4326

Met Leu Ser Leu Lys Leu Pro Arg Leu Phe Ser Ile Asp Gln Ile Pro 
1               5                   10                  15      


Gln Val Phe His Glu Gln Gly Ile Leu Phe Gly Tyr Arg His Pro Gln 
            20                  25                  30          


Ser Ser Ala Thr Ala Cys Ile Leu Ser Leu Phe Gln Met Thr Asn Glu 
        35                  40                  45              


Thr Leu Asn Ile Trp Thr His Leu Leu Pro Phe Trp Phe Phe Ala Trp 
    50                  55                  60                  


Arg Phe Val Thr Ala Leu Tyr Met Thr Asp Ile Lys Asn Asp Ser Tyr 
65                  70                  75                  80  


Ser Trp Pro Met Leu Val Tyr Met Cys Thr Ser Cys Val Tyr Pro Leu 
                85                  90                  95      


Val Ser Ser Cys Ala His Thr Phe Ser Ser Met Ser Lys Asn Ala Arg 
            100                 105                 110         


His Ile Cys Tyr Phe Leu Asp Tyr Gly Ala Val Asn Leu Phe Ser Leu 
        115                 120                 125             


Gly Ser Ala Ile Ala Tyr Ser Ala Tyr Thr Phe Pro Asp Ala Leu Met 
    130                 135                 140                 


Cys Thr Thr Phe His Asp Tyr Tyr Val Ala Leu Ala Val Leu Asn Thr 
145                 150                 155                 160 


Ile Leu Ser Thr Gly Leu Ser Cys Tyr Ser Arg Phe Leu Glu Ile Gln 
                165                 170                 175     


Lys Pro Arg Leu Cys Lys Val Ile Arg Val Leu Ala Phe Ala Tyr Pro 
            180                 185                 190         


Tyr Thr Trp Asp Ser Leu Pro Ile Phe Tyr Arg Leu Phe Leu Phe Pro 
        195                 200                 205             


Gly Glu Ser Ala Gln Asn Glu Ala Thr Ser Tyr His Gln Lys His Met 
    210                 215                 220                 


Ile Met Thr Leu Leu Ala Ser Phe Leu Tyr Ser Ala His Leu Pro Glu 
225                 230                 235                 240 


Arg Leu Ala Pro Gly Arg Phe Asp Tyr Ile Gly His Ser His Gln Leu 
                245                 250                 255     


Phe His Val Cys Val Ile Leu Ala Thr His Met Gln Met Glu Ala Ile 
            260                 265                 270         


Leu Leu Asp Lys Thr Leu Arg Lys Glu Trp Leu Leu Ala Thr Ser Lys 
        275                 280                 285             


Pro Phe Ser Phe Ser Gln Ile Ala Gly Ala Ile Leu Leu Cys Ile Ile 
    290                 295                 300                 


Phe Ser Leu Ser Asn Ile Ile Tyr Phe Ser Ala Ala Leu Tyr Arg Ile 
305                 310                 315                 320 


Pro Lys Pro Glu Leu His Lys Lys Glu Thr 
                325                 330 


<210>  4327
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  4327

Met Ala Glu Ser Pro Gly Cys Cys Ser Val Trp Ala Arg Cys Leu His 
1               5                   10                  15      


Cys Leu Tyr Ser Cys His Trp Arg Lys Cys Pro Arg Glu Arg Met Gln 
            20                  25                  30          


Thr Ser Lys Cys Asp Cys Ile Trp Phe Gly Leu Leu Phe Leu Thr Phe 
        35                  40                  45              


Leu Leu Ser Leu Ser Trp Leu Tyr Ile Gly Leu Val Leu Leu Asn Asp 
    50                  55                  60                  


Leu His Asn Phe Asn Glu Phe Leu Phe Arg Arg Trp Gly His Trp Met 
65                  70                  75                  80  


Asp Trp Ser Leu Ala Phe Leu Leu Val Ile Ser Leu Leu Val Thr Tyr 
                85                  90                  95      


Ala Ser Leu Leu Leu Val Leu Ala Leu Leu Leu Arg Leu Cys Arg Gln 
            100                 105                 110         


Pro Leu His Leu His Ser Leu His Lys Val Leu Leu Leu Leu Ile Met 
        115                 120                 125             


Leu Leu Val Ala Ala Gly Leu Val Gly Leu Asp Ile Gln Trp Gln Gln 
    130                 135                 140                 


Glu Trp His Ser Leu Arg Val Ser Leu Gln Ala Thr Ala Pro Phe Leu 
145                 150                 155                 160 


His Ile Gly Ala Ala Ala Gly Ile Ala Leu Leu Ala Trp Pro Val Ala 
                165                 170                 175     


Asp Thr Phe Tyr Arg Ile His Arg Arg Gly Pro Lys Ile Leu Leu Leu 
            180                 185                 190         


Leu Leu Phe Phe Gly Val Val Leu Val Ile Tyr Leu Ala Pro Leu Cys 
        195                 200                 205             


Ile Ser Ser Pro Cys Ile Met Glu Pro Arg Asp Leu Pro Pro Lys Pro 
    210                 215                 220                 


Gly Leu Val Gly His Arg Gly Ala Pro Met Leu Ala Pro Glu Asn Thr 
225                 230                 235                 240 


Leu Met Ser Leu Arg Lys Thr Ala Glu Cys Gly Ala Thr Val Phe Glu 
                245                 250                 255     


Thr Asp Val Met Val Ser Ser Asp Gly Val Pro Phe Leu Met His Asp 
            260                 265                 270         


Glu His Leu Ser Arg Thr Thr Asn Val Ala Ser Val Phe Pro Thr Arg 
        275                 280                 285             


Ile Thr Ala His Ser Ser Asp Phe Ser Trp Thr Glu Leu Lys Arg Leu 
    290                 295                 300                 


Asn Ala Gly Ser Trp Phe Leu Glu Arg Arg Pro Phe Trp Gly Ala Lys 
305                 310                 315                 320 


Pro Leu Ala Gly Pro Asp Gln Lys Glu Ala Glu Ser Gln Thr Val Pro 
                325                 330                 335     


Ala Leu Glu Glu Leu Leu Glu Glu Ala Ala Ala Leu Asn Leu Ser Ile 
            340                 345                 350         


Met Phe Asp Leu Arg Arg Pro Pro Gln Asn His Thr Tyr Tyr Asp Thr 
        355                 360                 365             


Phe Val Ile Gln Thr Leu Glu Thr Val Leu Asn Ala Arg Val Pro Gln 
    370                 375                 380                 


Ala Met Val Phe Trp Leu Pro Asp Glu Asp Arg Ala Asn Val Gln Arg 
385                 390                 395                 400 


Arg Ala Pro Gly Met Arg Gln Ile Tyr Gly Arg Gln Gly Gly Asn Arg 
                405                 410                 415     


Thr Glu Arg Pro Gln Phe Leu Asn Leu Pro Tyr Gln Asp Leu Pro Leu 
            420                 425                 430         


Leu Asp Ile Lys Ala Leu His Lys Asp Asn Val Ser Val Asn Leu Phe 
        435                 440                 445             


Val Val Asn Lys Pro Trp Leu Phe Ser Leu Leu Trp Cys Ala Gly Val 
    450                 455                 460                 


Asp Ser Val Thr Thr Asn Asp Cys Gln Leu Leu Gln Gln Met Arg Tyr 
465                 470                 475                 480 


Pro Ile Trp Leu Ile Thr Pro Gln Thr Tyr Leu Ile Ile Trp Val Ile 
                485                 490                 495     


Thr Asn Cys Val Ser Thr Met Leu Leu Leu Trp Thr Phe Leu Leu Gln 
            500                 505                 510         


Arg Arg Phe Val Lys Lys Arg Gly Lys Thr Gly Leu Glu Thr Ala Val 
        515                 520                 525             


Leu Leu Thr Arg Ile Asn Asn Phe Met Met Glu 
    530                 535                 


<210>  4328
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  4328

Met Met Ser Ser Lys Pro Thr Ser His Ala Glu Val Asn Glu Thr Ile 
1               5                   10                  15      


Pro Asn Pro Tyr Pro Pro Ser Ser Phe Met Ala Pro Gly Phe Gln Gln 
            20                  25                  30          


Pro Leu Gly Ser Ile Asn Leu Glu Asn Gln Ala Gln Gly Ala Gln Arg 
        35                  40                  45              


Ala Gln Pro Tyr Gly Ile Thr Ser Pro Gly Ile Phe Ala Ser Ser Gln 
    50                  55                  60                  


Pro Gly Gln Gly Asn Ile Gln Met Ile Asn Pro Ser Val Gly Thr Ala 
65                  70                  75                  80  


Val Met Asn Phe Lys Glu Glu Ala Lys Ala Leu Gly Val Ile Gln Ile 
                85                  90                  95      


Met Val Gly Leu Met His Ile Gly Phe Gly Ile Val Leu Cys Leu Ile 
            100                 105                 110         


Ser Phe Ser Phe Arg Glu Val Leu Gly Phe Ala Ser Thr Ala Val Ile 
        115                 120                 125             


Gly Gly Tyr Pro Phe Trp Gly Gly Leu Ser Phe Ile Ile Ser Gly Ser 
    130                 135                 140                 


Leu Ser Val Ser Ala Ser Lys Glu Leu Ser Arg Cys Leu Val Lys Gly 
145                 150                 155                 160 


Ser Leu Gly Met Asn Ile Val Ser Ser Ile Leu Ala Phe Ile Gly Val 
                165                 170                 175     


Ile Leu Leu Leu Val Asp Met Cys Ile Asn Gly Val Ala Gly Gln Asp 
            180                 185                 190         


Tyr Trp Ala Val Leu Ser Gly Lys Gly Ile Ser Ala Thr Leu Met Ile 
        195                 200                 205             


Phe Ser Leu Leu Glu Phe Phe Val Ala Cys Ala Thr Ala His Phe Ala 
    210                 215                 220                 


Asn Gln Ala Asn Thr Thr Thr Asn Met Ser Val Leu Val Ile Pro Asn 
225                 230                 235                 240 


Met Tyr Glu Ser Asn Pro Val Thr Pro Ala Ser Ser Ser Ala Pro Pro 
                245                 250                 255     


Arg Cys Asn Asn Tyr Ser Ala Asn Ala Pro Lys 
            260                 265         


<210>  4329
<211>  496
<212>  PRT
<213>  Homo sapiens

<400>  4329

Met Ala Gly Glu Ile Thr Glu Thr Gly Glu Leu Tyr Ser Ser Tyr Val 
1               5                   10                  15      


Gly Leu Val Tyr Met Phe Asn Leu Ile Val Gly Thr Gly Ala Leu Thr 
            20                  25                  30          


Met Pro Lys Ala Phe Ala Thr Ala Gly Trp Leu Val Ser Leu Val Leu 
        35                  40                  45              


Leu Val Phe Leu Gly Phe Met Ser Phe Val Thr Thr Thr Phe Val Ile 
    50                  55                  60                  


Glu Ala Met Ala Ala Ala Asn Ala Gln Leu His Trp Lys Arg Met Glu 
65                  70                  75                  80  


Asn Leu Lys Glu Glu Glu Asp Asp Asp Ser Ser Thr Ala Ser Asp Ser 
                85                  90                  95      


Asp Val Leu Ile Arg Asp Asn Tyr Glu Arg Ala Glu Lys Arg Pro Ile 
            100                 105                 110         


Leu Ser Val Gln Arg Arg Gly Ser Pro Asn Pro Phe Glu Ile Thr Asp 
        115                 120                 125             


Arg Val Glu Met Gly Gln Met Ala Ser Met Phe Phe Asn Lys Val Gly 
    130                 135                 140                 


Val Asn Leu Phe Tyr Phe Cys Ile Ile Val Tyr Leu Tyr Gly Asp Leu 
145                 150                 155                 160 


Ala Ile Tyr Ala Ala Ala Val Pro Phe Ser Leu Met Gln Val Thr Cys 
                165                 170                 175     


Ser Ala Thr Gly Asn Asp Ser Cys Gly Val Glu Ala Asp Thr Lys Tyr 
            180                 185                 190         


Asn Asp Thr Asp Arg Cys Trp Gly Pro Leu Arg Arg Val Asp Ala Tyr 
        195                 200                 205             


Arg Ile Tyr Leu Ala Ile Phe Thr Leu Leu Leu Gly Pro Phe Thr Phe 
    210                 215                 220                 


Phe Asp Val Gln Lys Thr Lys Tyr Leu Gln Ile Leu Thr Ser Leu Met 
225                 230                 235                 240 


Arg Trp Ile Ala Phe Ala Val Met Ile Val Leu Ala Leu Ile Arg Ile 
                245                 250                 255     


Gly His Gly Gln Gly Glu Gly His Pro Pro Leu Ala Asp Phe Ser Gly 
            260                 265                 270         


Val Arg Asn Leu Phe Gly Val Cys Val Tyr Ser Phe Met Cys Gln His 
        275                 280                 285             


Ser Leu Pro Ser Leu Ile Thr Pro Val Ser Ser Lys Arg His Leu Thr 
    290                 295                 300                 


Arg Leu Val Phe Leu Asp Tyr Val Leu Ile Leu Ala Phe Tyr Gly Leu 
305                 310                 315                 320 


Leu Ser Phe Thr Ala Ile Phe Cys Phe Arg Gly Asp Ser Leu Met Asp 
                325                 330                 335     


Met Tyr Thr Leu Asn Phe Ala Arg Cys Asp Val Val Gly Leu Ala Ala 
            340                 345                 350         


Val Arg Phe Phe Leu Gly Leu Phe Pro Val Phe Thr Ile Ser Thr Asn 
        355                 360                 365             


Phe Pro Ile Ile Ala Val Thr Leu Arg Asn Asn Trp Lys Thr Leu Phe 
    370                 375                 380                 


His Arg Glu Gly Gly Thr Tyr Pro Trp Val Val Asp Arg Val Val Phe 
385                 390                 395                 400 


Pro Thr Ile Thr Leu Val Pro Pro Val Leu Val Ala Phe Cys Thr His 
                405                 410                 415     


Asp Leu Glu Ser Leu Val Gly Ile Thr Gly Ala Tyr Ala Gly Thr Gly 
            420                 425                 430         


Ile Gln Tyr Val Ile Pro Ala Phe Leu Val Tyr His Cys Arg Arg Asp 
        435                 440                 445             


Thr Gln Leu Ala Phe Gly Cys Gly Val Ser Asn Lys His Arg Ser Pro 
    450                 455                 460                 


Phe Arg His Thr Phe Trp Val Gly Phe Val Leu Leu Trp Ala Phe Ser 
465                 470                 475                 480 


Cys Phe Ile Phe Val Thr Ala Asn Ile Ile Leu Ser Glu Thr Lys Leu 
                485                 490                 495     


<210>  4330
<211>  975
<212>  PRT
<213>  Homo sapiens

<400>  4330

Met Arg Leu Gly Ser Gly Thr Phe Ala Thr Cys Cys Val Ala Ile Glu 
1               5                   10                  15      


Val Leu Gly Ile Ala Val Phe Leu Arg Gly Phe Phe Pro Ala Pro Val 
            20                  25                  30          


Arg Ser Ser Ala Arg Ala Glu His Gly Ala Glu Pro Pro Ala Pro Glu 
        35                  40                  45              


Pro Ser Ala Gly Ala Ser Ser Asn Trp Thr Thr Leu Pro Pro Pro Leu 
    50                  55                  60                  


Phe Ser Lys Val Val Ile Val Leu Ile Asp Ala Leu Arg Asp Asp Phe 
65                  70                  75                  80  


Val Phe Gly Ser Lys Gly Val Lys Phe Met Pro Tyr Thr Thr Tyr Leu 
                85                  90                  95      


Val Glu Lys Gly Ala Ser His Ser Phe Val Ala Glu Ala Lys Pro Pro 
            100                 105                 110         


Thr Val Thr Met Pro Arg Ile Lys Ala Leu Met Thr Gly Ser Leu Pro 
        115                 120                 125             


Gly Phe Val Asp Val Ile Arg Asn Leu Asn Ser Pro Ala Leu Leu Glu 
    130                 135                 140                 


Asp Ser Val Ile Arg Gln Ala Lys Ala Ala Gly Lys Arg Ile Val Phe 
145                 150                 155                 160 


Tyr Gly Asp Glu Thr Trp Val Lys Leu Phe Pro Lys His Phe Val Glu 
                165                 170                 175     


Tyr Asp Gly Thr Thr Ser Phe Phe Val Ser Asp Tyr Thr Glu Val Asp 
            180                 185                 190         


Asn Asn Val Thr Arg His Leu Asp Lys Val Leu Lys Arg Gly Asp Trp 
        195                 200                 205             


Asp Ile Leu Ile Leu His Tyr Leu Gly Leu Asp His Ile Gly His Ile 
    210                 215                 220                 


Ser Gly Pro Asn Ser Pro Leu Ile Gly Gln Lys Leu Ser Glu Met Asp 
225                 230                 235                 240 


Ser Val Leu Met Lys Ile His Thr Ser Leu Gln Ser Lys Glu Arg Glu 
                245                 250                 255     


Thr Pro Leu Pro Asn Leu Leu Val Leu Cys Gly Asp His Gly Met Ser 
            260                 265                 270         


Glu Thr Gly Ser His Gly Ala Ser Ser Thr Glu Glu Val Asn Thr Pro 
        275                 280                 285             


Leu Ile Leu Ile Ser Ser Ala Phe Glu Arg Lys Pro Gly Asp Ile Arg 
    290                 295                 300                 


His Pro Lys His Val Gln Gln Thr Asp Val Ala Ala Thr Leu Ala Ile 
305                 310                 315                 320 


Ala Leu Gly Leu Pro Ile Pro Lys Asp Ser Val Gly Ser Leu Leu Phe 
                325                 330                 335     


Pro Val Val Glu Gly Arg Pro Met Arg Glu Gln Leu Arg Phe Leu His 
            340                 345                 350         


Leu Asn Thr Val Gln Leu Ser Lys Leu Leu Gln Glu Asn Val Pro Ser 
        355                 360                 365             


Tyr Glu Lys Asp Pro Gly Phe Glu Gln Phe Lys Met Ser Glu Arg Leu 
    370                 375                 380                 


His Gly Asn Trp Ile Arg Leu Tyr Leu Glu Glu Lys His Ser Glu Val 
385                 390                 395                 400 


Leu Phe Asn Leu Gly Ser Lys Val Leu Arg Gln Tyr Leu Asp Ala Leu 
                405                 410                 415     


Lys Thr Leu Ser Leu Ser Leu Ser Ala Gln Val Ala Gln Tyr Asp Ile 
            420                 425                 430         


Tyr Ser Met Met Val Leu Thr Leu Leu Leu Leu Ser Val Pro Gln Ala 
        435                 440                 445             


Leu Arg Arg Lys Ala Glu Leu Glu Val Pro Leu Ser Ser Pro Gly Phe 
    450                 455                 460                 


Ser Leu Leu Phe Tyr Leu Val Ile Leu Val Leu Ser Ala Val His Val 
465                 470                 475                 480 


Ile Val Cys Thr Ser Ala Glu Ser Ser Cys Tyr Phe Cys Gly Leu Ser 
                485                 490                 495     


Trp Leu Ala Ala Gly Gly Val Met Val Leu Ala Ser Ala Leu Leu Cys 
            500                 505                 510         


Val Ile Val Ser Val Leu Thr Asn Val Leu Val Gly Gly Asn Thr Pro 
        515                 520                 525             


Arg Lys Asn Pro Met His Pro Ser Ser Arg Trp Ser Glu Leu Asp Leu 
    530                 535                 540                 


Leu Ile Leu Leu Gly Thr Ala Gly His Val Leu Ser Leu Gly Ala Ser 
545                 550                 555                 560 


Ser Phe Val Glu Glu Glu His Gln Thr Trp Tyr Phe Leu Val Asn Thr 
                565                 570                 575     


Leu Cys Leu Ala Leu Ser Gln Glu Thr Tyr Arg Asn Tyr Phe Leu Gly 
            580                 585                 590         


Asp Asp Gly Glu Pro Pro Cys Gly Leu Cys Val Glu Gln Gly His Asp 
        595                 600                 605             


Gly Ala Thr Ala Ala Trp Gln Asp Gly Pro Gly Cys Asp Val Leu Glu 
    610                 615                 620                 


Arg Asp Lys Gly His Gly Ser Pro Ser Thr Ser Glu Val Leu Arg Gly 
625                 630                 635                 640 


Arg Glu Lys Trp Met Val Leu Ala Ser Pro Trp Leu Ile Leu Ala Cys 
                645                 650                 655     


Cys Arg Leu Leu Arg Ser Leu Asn Gln Thr Gly Val Gln Trp Ala His 
            660                 665                 670         


Arg Pro Asp Leu Gly His Trp Leu Thr Ser Ser Asp His Lys Ala Glu 
        675                 680                 685             


Leu Ser Val Leu Ala Ala Leu Ser Leu Leu Val Val Phe Val Leu Val 
    690                 695                 700                 


Gln Arg Gly Cys Ser Pro Val Ser Lys Ala Ala Leu Ala Leu Gly Leu 
705                 710                 715                 720 


Leu Gly Val Tyr Cys Tyr Arg Ala Ala Ile Gly Ser Val Arg Phe Pro 
                725                 730                 735     


Trp Arg Pro Asp Ser Lys Asp Ile Ser Lys Gly Ile Ile Glu Ala Arg 
            740                 745                 750         


Phe Val Tyr Val Phe Val Leu Gly Ile Leu Phe Thr Gly Thr Lys Asp 
        755                 760                 765             


Leu Leu Lys Ser Gln Val Ile Ala Ala Asp Phe Lys Leu Lys Thr Val 
    770                 775                 780                 


Gly Leu Trp Glu Ile Tyr Ser Gly Leu Val Leu Leu Ala Ala Leu Leu 
785                 790                 795                 800 


Phe Arg Pro His Asn Leu Pro Val Leu Ala Phe Ser Leu Leu Ile Gln 
                805                 810                 815     


Thr Leu Met Thr Lys Phe Ile Trp Lys Pro Leu Arg His Asp Ala Ala 
            820                 825                 830         


Glu Ile Thr Val Met His Tyr Trp Phe Gly Gln Ala Phe Phe Tyr Phe 
        835                 840                 845             


Gln Gly Asn Ser Asn Asn Ile Ala Thr Val Asp Ile Ser Ala Gly Phe 
    850                 855                 860                 


Val Gly Leu Asp Thr Tyr Val Glu Ile Pro Ala Val Leu Leu Thr Ala 
865                 870                 875                 880 


Phe Gly Thr Tyr Ala Gly Pro Val Leu Trp Ala Ser His Leu Val His 
                885                 890                 895     


Phe Leu Ser Ser Glu Thr Arg Ser Gly Ser Ala Leu Ser His Ala Cys 
            900                 905                 910         


Phe Cys Tyr Ala Leu Ile Cys Ser Ile Pro Val Phe Thr Tyr Ile Val 
        915                 920                 925             


Leu Val Thr Ser Leu Arg Tyr His Leu Phe Ile Trp Ser Val Phe Ser 
    930                 935                 940                 


Pro Lys Leu Leu Tyr Glu Gly Met His Leu Leu Ile Thr Ala Ala Val 
945                 950                 955                 960 


Cys Val Phe Phe Thr Ala Met Asp Gln Thr Arg Leu Thr Gln Ser 
                965                 970                 975 


<210>  4331
<211>  660
<212>  PRT
<213>  Homo sapiens

<400>  4331

Met Asp Asp Trp Lys Pro Ser Pro Leu Ile Lys Pro Phe Gly Ala Arg 
1               5                   10                  15      


Lys Lys Arg Ser Trp Tyr Leu Thr Trp Lys Tyr Lys Leu Thr Asn Gln 
            20                  25                  30          


Arg Ala Leu Arg Arg Phe Cys Gln Thr Gly Ala Val Leu Phe Leu Leu 
        35                  40                  45              


Val Thr Val Ile Val Asn Ile Lys Leu Ile Leu Asp Thr Arg Arg Ala 
    50                  55                  60                  


Ile Ser Glu Ala Asn Glu Asp Pro Glu Pro Glu Gln Asp Tyr Asp Glu 
65                  70                  75                  80  


Ala Leu Gly Arg Leu Glu Pro Pro Arg Arg Arg Gly Ser Gly Pro Arg 
                85                  90                  95      


Arg Val Leu Asp Val Glu Val Tyr Ser Ser Arg Ser Lys Val Tyr Val 
            100                 105                 110         


Ala Val Asp Gly Thr Thr Val Leu Glu Asp Glu Ala Arg Glu Gln Gly 
        115                 120                 125             


Arg Gly Ile His Val Ile Val Leu Asn Gln Ala Thr Gly His Val Met 
    130                 135                 140                 


Ala Lys Arg Val Phe Asp Thr Tyr Ser Pro His Glu Asp Glu Ala Met 
145                 150                 155                 160 


Val Leu Phe Leu Asn Met Val Ala Pro Gly Arg Val Leu Ile Cys Thr 
                165                 170                 175     


Val Lys Asp Glu Gly Ser Phe His Leu Lys Asp Thr Ala Lys Ala Leu 
            180                 185                 190         


Leu Arg Ser Leu Gly Ser Gln Ala Gly Pro Ala Leu Gly Trp Arg Asp 
        195                 200                 205             


Thr Trp Ala Phe Val Gly Arg Lys Gly Gly Pro Val Phe Gly Glu Lys 
    210                 215                 220                 


His Ser Lys Ser Pro Ala Leu Ser Ser Trp Gly Asp Pro Val Leu Leu 
225                 230                 235                 240 


Lys Thr Asp Val Pro Leu Ser Ser Ala Glu Glu Ala Glu Cys His Trp 
                245                 250                 255     


Ala Asp Thr Glu Leu Asn Arg Arg Arg Arg Arg Phe Cys Ser Lys Val 
            260                 265                 270         


Glu Gly Tyr Gly Ser Val Cys Ser Cys Lys Asp Pro Thr Pro Ile Glu 
        275                 280                 285             


Phe Ser Pro Asp Pro Leu Pro Asp Asn Lys Val Leu Asn Val Pro Val 
    290                 295                 300                 


Ala Val Ile Ala Gly Asn Arg Pro Asn Tyr Leu Tyr Arg Met Leu Arg 
305                 310                 315                 320 


Ser Leu Leu Ser Ala Gln Gly Val Ser Pro Gln Met Ile Thr Val Phe 
                325                 330                 335     


Ile Asp Gly Tyr Tyr Glu Glu Pro Met Asp Val Val Ala Leu Phe Gly 
            340                 345                 350         


Leu Arg Gly Ile Gln His Thr Pro Ile Ser Ile Lys Asn Ala Arg Val 
        355                 360                 365             


Ser Gln His Tyr Lys Ala Ser Leu Thr Ala Thr Phe Asn Leu Phe Pro 
    370                 375                 380                 


Glu Ala Lys Phe Ala Val Val Leu Glu Glu Asp Leu Asp Ile Ala Val 
385                 390                 395                 400 


Asp Phe Phe Ser Phe Leu Ser Gln Ser Ile His Leu Leu Glu Glu Asp 
                405                 410                 415     


Asp Ser Leu Tyr Cys Ile Ser Ala Trp Asn Asp Gln Gly Tyr Glu His 
            420                 425                 430         


Thr Ala Glu Asp Pro Ala Leu Leu Tyr Arg Val Glu Thr Met Pro Gly 
        435                 440                 445             


Leu Gly Trp Val Leu Arg Arg Ser Leu Tyr Lys Glu Glu Leu Glu Pro 
    450                 455                 460                 


Lys Trp Pro Thr Pro Glu Lys Leu Trp Asp Trp Asp Met Trp Met Arg 
465                 470                 475                 480 


Met Pro Glu Gln Arg Arg Gly Arg Glu Cys Ile Ile Pro Asp Val Ser 
                485                 490                 495     


Arg Ser Tyr His Phe Gly Ile Val Gly Leu Asn Met Asn Gly Tyr Phe 
            500                 505                 510         


His Glu Ala Tyr Phe Lys Lys His Lys Phe Asn Thr Val Pro Gly Val 
        515                 520                 525             


Gln Leu Arg Asn Val Asp Ser Leu Lys Lys Glu Ala Tyr Glu Val Glu 
    530                 535                 540                 


Val His Arg Leu Leu Ser Glu Ala Glu Val Leu Asp His Ser Lys Asn 
545                 550                 555                 560 


Pro Cys Glu Asp Ser Phe Leu Pro Asp Thr Glu Gly His Thr Tyr Val 
                565                 570                 575     


Ala Phe Ile Arg Met Glu Lys Asp Asp Asp Phe Thr Thr Trp Thr Gln 
            580                 585                 590         


Leu Ala Lys Cys Leu His Ile Trp Asp Leu Asp Val Arg Gly Asn His 
        595                 600                 605             


Arg Gly Leu Trp Arg Leu Phe Arg Lys Lys Asn His Phe Leu Val Val 
    610                 615                 620                 


Gly Val Pro Ala Ser Pro Tyr Ser Val Lys Lys Pro Pro Ser Val Thr 
625                 630                 635                 640 


Pro Ile Phe Leu Glu Pro Pro Pro Lys Glu Glu Gly Ala Pro Gly Ala 
                645                 650                 655     


Pro Glu Gln Thr 
            660 


<210>  4332
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  4332

Met Gln Pro Ser Gly His Arg Leu Arg Asp Val Glu His His Pro Leu 
1               5                   10                  15      


Leu Ala Glu Asn Asp Asn Tyr Asp Ser Ser Ser Ser Ser Ser Ser Glu 
            20                  25                  30          


Ala Asp Val Ala Asp Arg Val Trp Phe Ile Arg Asp Gly Cys Gly Met 
        35                  40                  45              


Ile Cys Ala Val Met Thr Trp Leu Leu Val Ala Tyr Ala Asp Phe Val 
    50                  55                  60                  


Val Thr Phe Val Met Leu Leu Pro Ser Lys Asp Phe Trp Tyr Ser Val 
65                  70                  75                  80  


Val Asn Gly Val Ile Phe Asn Cys Leu Ala Val Leu Ala Leu Ser Ser 
                85                  90                  95      


His Leu Arg Thr Met Leu Thr Asp Pro Gly Ala Val Pro Lys Gly Asn 
            100                 105                 110         


Ala Thr Lys Glu Tyr Met Glu Ser Leu Gln Leu Lys Pro Gly Glu Val 
        115                 120                 125             


Ile Tyr Lys Cys Pro Lys Cys Cys Cys Ile Lys Pro Glu Arg Ala His 
    130                 135                 140                 


His Cys Ser Ile Cys Lys Arg Cys Ile Arg Lys Met Asp His His Cys 
145                 150                 155                 160 


Pro Trp Val Asn Asn Cys Val Gly Glu Lys Asn Gln Arg Phe Phe Val 
                165                 170                 175     


Leu Phe Thr Met Tyr Ile Ala Leu Ser Ser Val His Ala Leu Ile Leu 
            180                 185                 190         


Cys Gly Phe Gln Phe Ile Ser Cys Val Arg Gly Gln Trp Thr Glu Cys 
        195                 200                 205             


Ser Asp Phe Ser Pro Pro Ile Thr Val Ile Leu Leu Ile Phe Leu Cys 
    210                 215                 220                 


Leu Glu Gly Leu Leu Phe Phe Thr Phe Thr Ala Val Met Phe Gly Thr 
225                 230                 235                 240 


Gln Ile His Ser Ile Cys Asn Asp Glu Thr Glu Ile Glu Arg Leu Lys 
                245                 250                 255     


Ser Glu Lys Pro Thr Trp Glu Arg Arg Leu Arg Trp Glu Gly Met Lys 
            260                 265                 270         


Ser Val Phe Gly Gly Pro Pro Ser Leu Leu Trp Met Asn Pro Phe Val 
        275                 280                 285             


Gly Phe Arg Phe Arg Arg Leu Pro Thr Arg Pro Arg Lys Gly Gly Pro 
    290                 295                 300                 


Glu Phe Ser Val 
305             


<210>  4333
<211>  782
<212>  PRT
<213>  Homo sapiens

<400>  4333

Met Ala Ala Ala Met Glu Thr Glu Gln Leu Gly Val Glu Ile Phe Glu 
1               5                   10                  15      


Thr Ala Asp Cys Glu Glu Asn Ile Glu Ser Gln Asp Arg Pro Lys Leu 
            20                  25                  30          


Glu Pro Phe Tyr Val Glu Arg Tyr Ser Trp Ser Gln Leu Lys Lys Leu 
        35                  40                  45              


Leu Ala Asp Thr Arg Lys Tyr His Gly Tyr Met Met Ala Lys Ala Pro 
    50                  55                  60                  


His Asp Phe Met Phe Val Lys Arg Asn Asp Pro Asp Gly Pro His Ser 
65                  70                  75                  80  


Asp Arg Ile Tyr Tyr Leu Ala Met Ser Gly Glu Asn Arg Glu Asn Thr 
                85                  90                  95      


Leu Phe Tyr Ser Glu Ile Pro Lys Thr Ile Asn Arg Ala Ala Val Leu 
            100                 105                 110         


Met Leu Ser Trp Lys Pro Leu Leu Asp Leu Phe Gln Ala Thr Leu Asp 
        115                 120                 125             


Tyr Gly Met Tyr Ser Arg Glu Glu Glu Leu Leu Arg Glu Arg Lys Arg 
    130                 135                 140                 


Ile Gly Thr Val Gly Ile Ala Ser Tyr Asp Tyr His Gln Gly Ser Gly 
145                 150                 155                 160 


Thr Phe Leu Phe Gln Ala Gly Ser Gly Ile Tyr His Val Lys Asp Gly 
                165                 170                 175     


Gly Pro Gln Gly Phe Thr Gln Gln Pro Leu Arg Pro Asn Leu Val Glu 
            180                 185                 190         


Thr Ser Cys Pro Asn Ile Arg Met Asp Pro Lys Leu Cys Pro Ala Asp 
        195                 200                 205             


Pro Asp Trp Ile Ala Phe Ile His Ser Asn Asp Ile Trp Ile Ser Asn 
    210                 215                 220                 


Ile Val Thr Arg Glu Glu Arg Arg Leu Thr Tyr Val His Asn Glu Leu 
225                 230                 235                 240 


Ala Asn Met Glu Glu Asp Ala Arg Ser Ala Gly Val Ala Thr Phe Val 
                245                 250                 255     


Leu Gln Glu Glu Phe Asp Arg Tyr Ser Gly Tyr Trp Trp Cys Pro Lys 
            260                 265                 270         


Ala Glu Thr Thr Pro Ser Gly Gly Lys Ile Leu Arg Ile Leu Tyr Glu 
        275                 280                 285             


Glu Asn Asp Glu Ser Glu Val Glu Ile Ile His Val Thr Ser Pro Met 
    290                 295                 300                 


Leu Glu Thr Arg Arg Ala Asp Ser Phe Arg Tyr Pro Lys Thr Gly Thr 
305                 310                 315                 320 


Ala Asn Pro Lys Val Thr Phe Lys Met Ser Glu Ile Met Ile Asp Ala 
                325                 330                 335     


Glu Gly Arg Ile Ile Asp Val Ile Asp Lys Glu Leu Ile Gln Pro Phe 
            340                 345                 350         


Glu Ile Leu Phe Glu Gly Val Glu Tyr Ile Ala Arg Ala Gly Trp Thr 
        355                 360                 365             


Pro Glu Gly Lys Tyr Ala Trp Ser Ile Leu Leu Asp Arg Ser Gln Thr 
    370                 375                 380                 


Arg Leu Gln Ile Val Leu Ile Ser Pro Glu Leu Phe Ile Pro Val Glu 
385                 390                 395                 400 


Asp Asp Val Met Glu Arg Gln Arg Leu Ile Glu Ser Val Pro Asp Ser 
                405                 410                 415     


Val Thr Pro Leu Ile Ile Tyr Glu Glu Thr Thr Asp Ile Trp Ile Asn 
            420                 425                 430         


Ile His Asp Ile Phe His Val Phe Pro Gln Ser His Glu Glu Glu Ile 
        435                 440                 445             


Glu Phe Ile Phe Ala Ser Glu Cys Lys Thr Gly Phe Arg His Leu Tyr 
    450                 455                 460                 


Lys Ile Thr Ser Ile Leu Lys Glu Ser Lys Tyr Lys Arg Ser Ser Gly 
465                 470                 475                 480 


Gly Leu Pro Ala Pro Ser Asp Phe Lys Cys Pro Ile Lys Glu Glu Ile 
                485                 490                 495     


Ala Ile Thr Ser Gly Glu Trp Glu Val Leu Gly Arg His Gly Ser Asn 
            500                 505                 510         


Ile Gln Val Asp Glu Val Arg Arg Leu Val Tyr Phe Glu Gly Thr Lys 
        515                 520                 525             


Asp Ser Pro Leu Glu His His Leu Tyr Val Val Ser Tyr Val Asn Pro 
    530                 535                 540                 


Gly Glu Val Thr Arg Leu Thr Asp Arg Gly Tyr Ser His Ser Cys Cys 
545                 550                 555                 560 


Ile Ser Gln His Cys Asp Phe Phe Ile Ser Lys Tyr Ser Asn Gln Lys 
                565                 570                 575     


Asn Pro His Cys Val Ser Leu Tyr Lys Leu Ser Ser Pro Glu Asp Asp 
            580                 585                 590         


Pro Thr Cys Lys Thr Lys Glu Phe Trp Ala Thr Ile Leu Asp Ser Ala 
        595                 600                 605             


Gly Pro Leu Pro Asp Tyr Thr Pro Pro Glu Ile Phe Ser Phe Glu Ser 
    610                 615                 620                 


Thr Thr Gly Phe Thr Leu Tyr Gly Met Leu Tyr Lys Pro His Asp Leu 
625                 630                 635                 640 


Gln Pro Gly Lys Lys Tyr Pro Thr Val Leu Phe Ile Tyr Gly Gly Pro 
                645                 650                 655     


Gln Val Ala Ile Ala Gly Ala Pro Val Thr Leu Trp Ile Phe Tyr Asp 
            660                 665                 670         


Thr Gly Tyr Thr Glu Arg Tyr Met Gly His Pro Asp Gln Asn Glu Gln 
        675                 680                 685             


Gly Tyr Tyr Leu Gly Ser Val Ala Met Gln Ala Glu Lys Phe Pro Ser 
    690                 695                 700                 


Glu Pro Asn Arg Leu Leu Leu Leu His Gly Phe Leu Asp Glu Asn Val 
705                 710                 715                 720 


His Phe Ala His Thr Ser Ile Leu Leu Ser Phe Leu Val Arg Ala Gly 
                725                 730                 735     


Lys Pro Tyr Asp Leu Gln Ile Tyr Pro Gln Glu Arg His Ser Ile Arg 
            740                 745                 750         


Val Pro Glu Ser Gly Glu His Tyr Glu Leu His Leu Leu His Tyr Leu 
        755                 760                 765             


Gln Glu Asn Leu Gly Ser Arg Ile Ala Ala Leu Lys Val Ile 
    770                 775                 780         


<210>  4334
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  4334

Met Ala Asp Arg Gly Gly Val Gly Glu Ala Ala Ala Val Gly Ala Ser 
1               5                   10                  15      


Pro Ala Ser Val Pro Gly Leu Asn Pro Thr Leu Gly Trp Arg Glu Arg 
            20                  25                  30          


Leu Arg Ala Gly Leu Ala Gly Thr Gly Ala Ser Leu Trp Phe Val Ala 
        35                  40                  45              


Gly Leu Gly Leu Leu Tyr Ala Leu Arg Ile Pro Leu Arg Leu Cys Glu 
    50                  55                  60                  


Asn Leu Ala Ala Val Thr Val Phe Leu Asn Ser Leu Thr Pro Lys Phe 
65                  70                  75                  80  


Tyr Val Ala Leu Thr Gly Thr Ser Ser Leu Ile Ser Gly Leu Ile Phe 
                85                  90                  95      


Ile Phe Glu Trp Trp Tyr Phe His Lys His Gly Thr Ser Phe Ile Glu 
            100                 105                 110         


Gln Val Ser Val Ser His Leu Gln Pro Leu Met Gly Gly Thr Glu Ser 
        115                 120                 125             


Ser Ile Ser Glu Pro Gly Ser Pro Ser Arg Asn Arg Glu Asn Glu Thr 
    130                 135                 140                 


Ser Arg Gln Asn Leu Ser Glu Cys Lys Val Trp Arg Asn Pro Leu Asn 
145                 150                 155                 160 


Leu Phe Arg Gly Ala Glu Tyr Arg Arg Tyr Thr Trp Val Thr Gly Lys 
                165                 170                 175     


Glu Pro Leu Thr Tyr Tyr Asp Met Asn Leu Ser Ala Gln Asp His Gln 
            180                 185                 190         


Thr Phe Phe Thr Cys Asp Thr Asp Phe Leu Arg Pro Ser Asp Thr Val 
        195                 200                 205             


Met Gln Lys Ala Trp Arg Glu Arg Asn Pro Pro Ala Arg Ile Lys Ala 
    210                 215                 220                 


Ala Tyr Gln Ala Leu Glu Leu Asn Asn Asp Cys Ala Thr Ala Tyr Val 
225                 230                 235                 240 


Leu Leu Ala Glu Glu Glu Ala Thr Thr Ile Val Asp Ala Glu Arg Leu 
                245                 250                 255     


Phe Lys Gln Ala Leu Lys Ala Gly Glu Thr Ile Tyr Arg Gln Ser Gln 
            260                 265                 270         


Gln Cys Gln His Gln Ser Pro Gln His Glu Ala Gln Leu Arg Arg Asp 
        275                 280                 285             


Thr Asn Val Leu Val Tyr Ile Lys Arg Arg Leu Ala Met Cys Ala Arg 
    290                 295                 300                 


Lys Leu Gly Arg Ile Arg Glu Ala Val Lys Ile Met Arg Asp Leu Met 
305                 310                 315                 320 


Lys Glu Phe Pro Pro Leu Thr Met Leu Asn Ile His Glu Asn Leu Leu 
                325                 330                 335     


Glu Ser Leu Leu Glu Leu Gln Ala Tyr Pro Asp Val Gln Ala Val Leu 
            340                 345                 350         


Ala Lys Tyr Asp Asp Ile Ser Leu Pro Lys Ser Ala Ala Ile Cys Tyr 
        355                 360                 365             


Thr Ala Ala Leu Leu Lys Thr Arg Thr Val Ser Glu Lys Phe Ser Pro 
    370                 375                 380                 


Glu Thr Ala Ser Arg Arg Gly Leu Ser Thr Ala Glu Ile Asn Ala Val 
385                 390                 395                 400 


Glu Ala Ile His Arg Ala Val Glu Phe Asn Pro His Val Pro Lys Tyr 
                405                 410                 415     


Leu Leu Glu Met Lys Ser Leu Ile Leu Pro Pro Glu His Ile Leu Lys 
            420                 425                 430         


Arg Gly Asp Ser Glu Ala Ile Ala Tyr Ala Phe Phe His Leu Gln His 
        435                 440                 445             


Trp Lys Arg Ile Glu Gly Ala Leu Asn Leu Leu Gln Cys Thr Trp Glu 
    450                 455                 460                 


Gly Thr Phe Arg Met Ile Pro Tyr Pro Leu Glu Lys Gly His Leu Phe 
465                 470                 475                 480 


Tyr Pro Tyr Pro Ser Cys Thr Glu Thr Ala Asp Arg Glu Leu Leu Pro 
                485                 490                 495     


Thr Phe His His Val Ser Val Tyr Pro Lys Lys Glu Leu Pro Leu Phe 
            500                 505                 510         


Ile His Phe Thr Ala Gly Phe Cys Ser Ser Thr Ala Met Ile Ala Ile 
        515                 520                 525             


Leu Thr His Gln Phe Pro Glu Ile Met Gly Ile Phe Ala Lys Ala Val 
    530                 535                 540                 


Leu Gly Leu Trp Cys Pro Gln Pro Trp Ala Ser Ser Gly Phe Glu Glu 
545                 550                 555                 560 


Asn Thr Gln Asp Leu Lys Ser Glu Asp Leu Gly Leu Ser Ser Gly 
                565                 570                 575 


<210>  4335
<211>  610
<212>  PRT
<213>  Homo sapiens

<400>  4335

Met Trp Leu Pro Leu Val Leu Leu Leu Ala Val Leu Leu Leu Ala Val 
1               5                   10                  15      


Leu Cys Lys Val Tyr Leu Gly Leu Phe Ser Gly Ser Ser Pro Asn Pro 
            20                  25                  30          


Phe Ser Glu Asp Val Lys Arg Pro Pro Ala Pro Leu Val Thr Asp Lys 
        35                  40                  45              


Glu Ala Arg Lys Lys Val Leu Lys Gln Ala Phe Ser Ala Asn Gln Val 
    50                  55                  60                  


Pro Glu Lys Leu Asp Val Val Val Ile Gly Ser Gly Phe Gly Gly Leu 
65                  70                  75                  80  


Ala Ala Ala Ala Ile Leu Ala Lys Ala Gly Lys Arg Val Leu Val Leu 
                85                  90                  95      


Glu Gln His Thr Lys Ala Gly Gly Cys Cys His Thr Phe Gly Lys Asn 
            100                 105                 110         


Gly Leu Glu Phe Asp Thr Gly Ile His Tyr Ile Gly Arg Met Glu Glu 
        115                 120                 125             


Gly Ser Ile Gly Arg Phe Ile Leu Asp Gln Ile Thr Glu Gly Gln Leu 
    130                 135                 140                 


Asp Trp Ala Pro Leu Ser Ser Pro Phe Asp Ile Met Val Leu Glu Gly 
145                 150                 155                 160 


Pro Asn Gly Arg Lys Glu Tyr Pro Met Tyr Ser Gly Glu Lys Ala Tyr 
                165                 170                 175     


Ile Gln Gly Leu Lys Glu Lys Phe Pro Gln Glu Glu Ala Ile Ile Asp 
            180                 185                 190         


Lys Tyr Ile Lys Leu Val Lys Val Val Ser Ser Gly Ala Pro His Ala 
        195                 200                 205             


Ile Leu Leu Lys Phe Leu Pro Leu Pro Val Val Gln Leu Leu Asp Arg 
    210                 215                 220                 


Cys Gly Leu Leu Thr Arg Phe Ser Pro Phe Leu Gln Ala Ser Thr Gln 
225                 230                 235                 240 


Ser Leu Ala Glu Val Leu Gln Gln Leu Gly Ala Ser Ser Glu Leu Gln 
                245                 250                 255     


Ala Val Leu Ser Tyr Ile Phe Pro Thr Tyr Gly Val Thr Pro Asn His 
            260                 265                 270         


Ser Ala Phe Ser Met His Ala Leu Leu Val Asn His Tyr Met Lys Gly 
        275                 280                 285             


Gly Phe Tyr Pro Arg Gly Gly Ser Ser Glu Ile Ala Phe His Thr Ile 
    290                 295                 300                 


Pro Val Ile Gln Arg Ala Gly Gly Ala Val Leu Thr Lys Ala Thr Val 
305                 310                 315                 320 


Gln Ser Val Leu Leu Asp Ser Ala Gly Lys Ala Cys Gly Val Ser Val 
                325                 330                 335     


Lys Lys Gly His Glu Leu Val Asn Ile Tyr Cys Pro Ile Val Val Ser 
            340                 345                 350         


Asn Ala Gly Leu Phe Asn Thr Tyr Glu His Leu Leu Pro Gly Asn Ala 
        355                 360                 365             


Arg Cys Leu Pro Gly Val Lys Gln Gln Leu Gly Thr Val Arg Pro Gly 
    370                 375                 380                 


Leu Gly Met Thr Ser Val Phe Ile Cys Leu Arg Gly Thr Lys Glu Asp 
385                 390                 395                 400 


Leu His Leu Pro Ser Thr Asn Tyr Tyr Val Tyr Tyr Asp Thr Asp Met 
                405                 410                 415     


Asp Gln Ala Met Glu Arg Tyr Val Ser Met Pro Arg Glu Glu Ala Ala 
            420                 425                 430         


Glu His Ile Pro Leu Leu Phe Phe Ala Phe Pro Ser Ala Lys Asp Pro 
        435                 440                 445             


Thr Trp Glu Asp Arg Phe Pro Gly Arg Ser Thr Met Ile Met Leu Ile 
    450                 455                 460                 


Pro Thr Ala Tyr Glu Trp Phe Glu Glu Trp Gln Ala Glu Leu Lys Gly 
465                 470                 475                 480 


Lys Arg Gly Ser Asp Tyr Glu Thr Phe Lys Asn Ser Phe Val Glu Ala 
                485                 490                 495     


Ser Met Ser Val Val Leu Lys Leu Phe Pro Gln Leu Glu Gly Lys Val 
            500                 505                 510         


Glu Ser Val Thr Ala Gly Ser Pro Leu Thr Asn Gln Phe Tyr Leu Ala 
        515                 520                 525             


Ala Pro Arg Gly Ala Cys Tyr Gly Ala Asp His Asp Leu Gly Arg Leu 
    530                 535                 540                 


His Pro Cys Val Met Ala Ser Leu Arg Ala Gln Ser Pro Ile Pro Asn 
545                 550                 555                 560 


Leu Tyr Leu Thr Gly Gln Asp Ile Phe Thr Cys Gly Leu Val Gly Ala 
                565                 570                 575     


Leu Gln Gly Ala Leu Leu Cys Ser Ser Ala Ile Leu Lys Arg Asn Leu 
            580                 585                 590         


Tyr Ser Asp Leu Lys Asn Leu Asp Ser Arg Ile Arg Ala Gln Lys Lys 
        595                 600                 605             


Lys Asn 
    610 


<210>  4336
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  4336

Met Ala Val Gly Asn Asn Thr Gln Arg Ser Tyr Ser Ile Ile Pro Cys 
1               5                   10                  15      


Phe Ile Phe Val Glu Leu Val Ile Met Ala Gly Thr Val Leu Leu Ala 
            20                  25                  30          


Tyr Tyr Phe Glu Cys Thr Asp Thr Phe Gln Val His Ile Gln Gly Phe 
        35                  40                  45              


Phe Cys Gln Asp Gly Asp Leu Met Lys Pro Tyr Pro Gly Thr Glu Glu 
    50                  55                  60                  


Glu Ser Phe Ile Thr Pro Leu Val Leu Tyr Cys Val Leu Ala Ala Thr 
65                  70                  75                  80  


Pro Thr Ala Ile Ile Phe Ile Gly Glu Ile Ser Met Tyr Phe Ile Lys 
                85                  90                  95      


Ser Thr Arg Glu Ser Leu Ile Ala Gln Glu Lys Thr Ile Leu Thr Gly 
            100                 105                 110         


Glu Cys Cys Tyr Leu Asn Pro Leu Leu Arg Arg Ile Ile Arg Phe Thr 
        115                 120                 125             


Gly Val Phe Ala Phe Gly Leu Phe Ala Thr Asp Ile Phe Val Asn Ala 
    130                 135                 140                 


Gly Gln Val Val Thr Gly His Leu Thr Pro Tyr Phe Leu Thr Val Cys 
145                 150                 155                 160 


Lys Pro Asn Tyr Thr Ser Ala Asp Cys Gln Ala His His Gln Phe Ile 
                165                 170                 175     


Asn Asn Gly Asn Ile Cys Thr Gly Asp Leu Glu Val Ile Glu Lys Ala 
            180                 185                 190         


Arg Arg Ser Phe Pro Ser Lys His Ala Ala Leu Ser Ile Tyr Ser Ala 
        195                 200                 205             


Leu Tyr Ala Thr Met Tyr Ile Thr Ser Thr Ile Lys Thr Lys Ser Ser 
    210                 215                 220                 


Arg Leu Ala Lys Pro Val Leu Cys Leu Gly Thr Leu Cys Thr Ala Phe 
225                 230                 235                 240 


Leu Thr Gly Leu Asn Arg Val Ser Glu Tyr Arg Asn His Cys Ser Asp 
                245                 250                 255     


Val Ile Ala Gly Phe Ile Leu Gly Thr Ala Val Ala Leu Phe Leu Gly 
            260                 265                 270         


Met Cys Val Val His Asn Phe Lys Gly Thr Gln Gly Ser Pro Ser Lys 
        275                 280                 285             


Pro Lys Pro Glu Asp Pro Arg Gly Val Pro Leu Met Ala Phe Pro Arg 
    290                 295                 300                 


Ile Glu Ser Pro Leu Glu Thr Leu Ser Ala Gln Asn His Ser Ala Ser 
305                 310                 315                 320 


Met Thr Glu Val Thr 
                325 


<210>  4337
<211>  783
<212>  PRT
<213>  Homo sapiens

<400>  4337

Met Ser Gly Gly His Gln Leu Gln Leu Ala Ala Leu Trp Pro Trp Leu 
1               5                   10                  15      


Leu Met Ala Thr Leu Gln Ala Gly Phe Gly Arg Thr Gly Leu Val Leu 
            20                  25                  30          


Ala Ala Ala Val Glu Ser Glu Arg Ser Ala Glu Gln Lys Ala Ile Ile 
        35                  40                  45              


Arg Val Ile Pro Leu Lys Met Asp Pro Thr Gly Lys Leu Asn Leu Thr 
    50                  55                  60                  


Leu Glu Gly Val Phe Ala Gly Val Ala Glu Ile Thr Pro Ala Glu Gly 
65                  70                  75                  80  


Lys Leu Met Gln Ser His Pro Leu Tyr Leu Cys Asn Ala Ser Asp Asp 
                85                  90                  95      


Asp Asn Leu Glu Pro Gly Phe Ile Ser Ile Val Lys Leu Glu Ser Pro 
            100                 105                 110         


Arg Arg Ala Pro Arg Pro Cys Leu Ser Leu Ala Ser Lys Ala Arg Met 
        115                 120                 125             


Ala Gly Glu Arg Gly Ala Ser Ala Val Leu Phe Asp Ile Thr Glu Asp 
    130                 135                 140                 


Arg Ala Ala Ala Glu Gln Leu Gln Gln Pro Leu Gly Leu Thr Trp Pro 
145                 150                 155                 160 


Val Val Leu Ile Trp Gly Asn Asp Ala Glu Lys Leu Met Glu Phe Val 
                165                 170                 175     


Tyr Lys Asn Gln Lys Ala His Val Arg Ile Glu Leu Lys Glu Pro Pro 
            180                 185                 190         


Ala Trp Pro Asp Tyr Asp Val Trp Ile Leu Met Thr Val Val Gly Thr 
        195                 200                 205             


Ile Phe Val Ile Ile Leu Ala Ser Val Leu Arg Ile Arg Cys Arg Pro 
    210                 215                 220                 


Arg His Ser Arg Pro Asp Pro Leu Gln Gln Arg Thr Ala Trp Ala Ile 
225                 230                 235                 240 


Ser Gln Leu Ala Thr Arg Arg Tyr Gln Ala Ser Cys Arg Gln Ala Arg 
                245                 250                 255     


Gly Glu Trp Pro Asp Ser Gly Ser Ser Cys Ser Ser Ala Pro Val Cys 
            260                 265                 270         


Ala Ile Cys Leu Glu Glu Phe Ser Glu Gly Gln Glu Leu Arg Val Ile 
        275                 280                 285             


Ser Cys Leu His Glu Phe His Arg Asn Cys Val Asp Pro Trp Leu His 
    290                 295                 300                 


Gln His Arg Thr Cys Pro Leu Cys Met Phe Asn Ile Thr Glu Gly Asp 
305                 310                 315                 320 


Ser Phe Ser Gln Ser Leu Gly Pro Ser Arg Ser Tyr Gln Glu Pro Gly 
                325                 330                 335     


Arg Arg Leu His Leu Ile Arg Gln His Pro Gly His Ala His Tyr His 
            340                 345                 350         


Leu Pro Ala Ala Tyr Leu Leu Gly Pro Ser Arg Ser Ala Val Ala Arg 
        355                 360                 365             


Pro Pro Arg Pro Gly Pro Phe Leu Pro Ser Gln Glu Pro Gly Met Gly 
    370                 375                 380                 


Pro Arg His His Arg Phe Pro Arg Ala Ala His Pro Arg Ala Pro Gly 
385                 390                 395                 400 


Glu Gln Gln Arg Leu Ala Gly Ala Gln His Pro Tyr Ala Gln Gly Trp 
                405                 410                 415     


Gly Leu Ser His Leu Gln Ser Thr Ser Gln His Pro Ala Ala Cys Pro 
            420                 425                 430         


Val Pro Leu Arg Arg Ala Arg Pro Pro Asp Ser Ser Gly Ser Gly Glu 
        435                 440                 445             


Ser Tyr Cys Thr Glu Arg Ser Gly Tyr Leu Ala Asp Gly Pro Ala Ser 
    450                 455                 460                 


Asp Ser Ser Ser Gly Pro Cys His Gly Ser Ser Ser Asp Ser Val Val 
465                 470                 475                 480 


Asn Cys Thr Asp Ile Ser Leu Gln Gly Val His Gly Ser Ser Ser Thr 
                485                 490                 495     


Phe Cys Ser Ser Leu Ser Ser Asp Phe Asp Pro Leu Val Tyr Cys Ser 
            500                 505                 510         


Pro Lys Gly Asp Pro Gln Arg Val Asp Met Gln Pro Ser Val Thr Ser 
        515                 520                 525             


Arg Pro Arg Ser Leu Asp Ser Val Val Pro Thr Gly Glu Thr Gln Val 
    530                 535                 540                 


Ser Ser His Val His Tyr His Arg His Arg His His His Tyr Lys Lys 
545                 550                 555                 560 


Arg Phe Gln Trp His Gly Arg Lys Pro Gly Pro Glu Thr Gly Val Pro 
                565                 570                 575     


Gln Ser Arg Pro Pro Ile Pro Arg Thr Gln Pro Gln Pro Glu Pro Pro 
            580                 585                 590         


Ser Pro Asp Gln Gln Val Thr Arg Ser Asn Ser Ala Ala Pro Ser Gly 
        595                 600                 605             


Arg Leu Ser Asn Pro Gln Cys Pro Arg Ala Leu Pro Glu Pro Ala Pro 
    610                 615                 620                 


Gly Pro Val Asp Ala Ser Ser Ile Cys Pro Ser Thr Ser Ser Leu Phe 
625                 630                 635                 640 


Asn Leu Gln Lys Ser Ser Leu Ser Ala Arg His Pro Gln Arg Lys Arg 
                645                 650                 655     


Arg Gly Gly Pro Ser Glu Pro Thr Pro Gly Ser Arg Pro Gln Asp Ala 
            660                 665                 670         


Thr Val His Pro Ala Cys Gln Ile Phe Pro His Tyr Thr Pro Ser Val 
        675                 680                 685             


Ala Tyr Pro Trp Ser Pro Glu Ala His Pro Leu Ile Cys Gly Pro Pro 
    690                 695                 700                 


Gly Leu Asp Lys Arg Leu Leu Pro Glu Thr Pro Gly Pro Cys Tyr Ser 
705                 710                 715                 720 


Asn Ser Gln Pro Val Trp Leu Cys Leu Thr Pro Arg Gln Pro Leu Glu 
                725                 730                 735     


Pro His Pro Pro Gly Glu Gly Pro Ser Glu Trp Ser Ser Asp Thr Ala 
            740                 745                 750         


Glu Gly Arg Pro Cys Pro Tyr Pro His Cys Gln Val Leu Ser Ala Gln 
        755                 760                 765             


Pro Gly Ser Glu Glu Glu Leu Glu Glu Leu Cys Glu Gln Ala Val 
    770                 775                 780             


<210>  4338
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  4338

Met Val Trp Lys Lys Leu Gly Ser Arg Asn Phe Ser Ser Cys Pro Ser 
1               5                   10                  15      


Gly Ser Ile Gln Trp Ile Trp Asp Val Leu Gly Glu Cys Ala Gln Asp 
            20                  25                  30          


Gly Trp Asp Glu Ala Ser Val Gly Leu Gly Leu Ile Ser Ile Leu Cys 
        35                  40                  45              


Phe Ala Ala Ser Thr Phe Pro Gln Phe Ile Lys Ala Tyr Lys Thr Gly 
    50                  55                  60                  


Asn Met Asp Gln Ala Leu Ser Leu Trp Phe Leu Leu Gly Trp Ile Gly 
65                  70                  75                  80  


Gly Asp Ser Cys Asn Leu Ile Gly Ser Phe Leu Ala Asp Gln Leu Pro 
                85                  90                  95      


Leu Gln Thr Tyr Thr Ala Val Tyr Tyr Val Leu Ala Asp Leu Val Met 
            100                 105                 110         


Leu Thr Leu Tyr Phe Tyr Tyr Lys Phe Arg Thr Arg Pro Ser Leu Leu 
        115                 120                 125             


Ser Ala Pro Ile Asn Ser Val Leu Leu Phe Leu Met Gly Met Ala Cys 
    130                 135                 140                 


Ala Thr Pro Leu Leu Ser Ala Ala Gly Pro Val Ala Ala Pro Arg Glu 
145                 150                 155                 160 


Ala Phe Arg Gly Arg Ala Leu Leu Ser Val Glu Ser Gly Ser Lys Pro 
                165                 170                 175     


Phe Thr Arg Gln Glu Val Ile Gly Phe Val Ile Gly Ser Ile Ser Ser 
            180                 185                 190         


Val Leu Tyr Leu Leu Ser Arg Leu Pro Gln Ile Arg Thr Asn Phe Leu 
        195                 200                 205             


Arg Lys Ser Thr Gln Gly Ile Ser Tyr Ser Leu Phe Ala Leu Val Met 
    210                 215                 220                 


Leu Gly Asn Thr Leu Tyr Gly Leu Ser Val Leu Leu Lys Asn Pro Glu 
225                 230                 235                 240 


Glu Gly Gln Ser Glu Gly Ser Tyr Leu Leu His His Leu Pro Trp Leu 
                245                 250                 255     


Val Gly Ser Leu Gly Val Leu Leu Leu Asp Thr Ile Ile Ser Ile Gln 
            260                 265                 270         


Phe Leu Val Tyr Arg Arg Ser Thr Ala Ala Ser Glu Leu Glu Pro Leu 
        275                 280                 285             


Leu Pro Ser 
    290     


<210>  4339
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  4339

Met Val Asp Val Val Gly Leu Glu Arg Glu Thr Gly Pro Arg Gly Ser 
1               5                   10                  15      


Pro Trp Pro Gly Leu Pro Leu Pro Ser Leu Val Gly Pro Ala Pro Leu 
            20                  25                  30          


Leu Thr Cys Leu Cys Pro Gln Cys Leu Ser Val Glu Asp Ala Leu Gly 
        35                  40                  45              


Leu Gly Glu Pro Glu Gly Ser Gly Leu Pro Pro Gly Pro Val Leu Glu 
    50                  55                  60                  


Ala Arg Tyr Val Ala Arg Leu Ser Ala Ala Ala Val Leu Tyr Leu Ser 
65                  70                  75                  80  


Asn Pro Glu Gly Thr Cys Glu Asp Ala Arg Ala Gly Leu Trp Ala Ser 
                85                  90                  95      


His Ala Asp His Leu Leu Ala Leu Leu Glu Ser Pro Lys Ala Leu Thr 
            100                 105                 110         


Pro Gly Leu Ser Trp Leu Leu Gln Arg Met Gln Ala Arg Ala Ala Gly 
        115                 120                 125             


Gln Thr Pro Lys Thr Ala Cys Val Asp Ile Pro Gln Leu Leu Glu Glu 
    130                 135                 140                 


Ala Val Gly Ala Gly Ala Pro Gly Ser Ala Gly Gly Val Leu Ala Ala 
145                 150                 155                 160 


Leu Leu Asp His Val Arg Ser Gly Ser Cys Phe His Ala Leu Pro Ser 
                165                 170                 175     


Pro Gln Tyr Phe Val Asp Phe Val Phe Gln Gln His Ser Ser Glu Val 
            180                 185                 190         


Pro Met Thr Leu Ala Glu Leu Ser Ala Leu Met Gln Arg Leu Gly Val 
        195                 200                 205             


Gly Arg Glu Ala His Ser Asp His Ser His Arg His Arg Gly Ala Ser 
    210                 215                 220                 


Ser Arg Asp Pro Val Pro Leu Ile Ser Ser Ser Asn Ser Ser Ser Val 
225                 230                 235                 240 


Trp Asp Thr Val Cys Leu Ser Ala Arg Asp Val Met Ala Ala Tyr Gly 
                245                 250                 255     


Leu Ser Glu Gln Ala Gly Val Thr Pro Glu Ala Trp Ala Gln Leu Ser 
            260                 265                 270         


Pro Ala Leu Leu Gln Gln Gln Leu Ser Gly Ala Cys Thr Ser Gln Ser 
        275                 280                 285             


Arg Pro Pro Val Gln Asp Gln Leu Ser Gln Ser Glu Arg Tyr Leu Tyr 
    290                 295                 300                 


Gly Ser Leu Ala Thr Leu Leu Ile Cys Leu Cys Ala Val Phe Gly Leu 
305                 310                 315                 320 


Leu Leu Leu Thr Cys Thr Gly Cys Arg Gly Val Thr His Tyr Ile Leu 
                325                 330                 335     


Gln Thr Phe Leu Ser Leu Ala Val Gly Ala Leu Thr Gly Asp Ala Val 
            340                 345                 350         


Leu His Leu Thr Pro Lys Val Leu Gly Leu His Thr His Ser Glu Glu 
        355                 360                 365             


Gly Leu Ser Pro Gln Pro Thr Trp Arg Leu Leu Ala Met Leu Ala Gly 
    370                 375                 380                 


Leu Tyr Ala Phe Phe Leu Phe Glu Asn Leu Phe Asn Leu Leu Leu Pro 
385                 390                 395                 400 


Arg Asp Pro Glu Asp Leu Glu Asp Gly Pro Cys Gly His Ser Ser His 
                405                 410                 415     


Ser His Gly Gly His Ser His Gly Val Ser Leu Gln Leu Ala Pro Ser 
            420                 425                 430         


Glu Leu Arg Gln Pro Lys Pro Pro His Glu Gly Ser Arg Ala Asp Leu 
        435                 440                 445             


Val Ala Glu Glu Ser Pro Glu Leu Leu Asn Pro Glu Pro Arg Arg Leu 
    450                 455                 460                 


Ser Pro Glu Leu Arg Leu Leu Pro Tyr Met Ile Thr Leu Gly Asp Ala 
465                 470                 475                 480 


Val His Asn Phe Ala Asp Gly Leu Ala Val Gly Ala Ala Phe Ala Ser 
                485                 490                 495     


Ser Trp Lys Thr Gly Leu Ala Thr Ser Leu Ala Val Phe Cys His Glu 
            500                 505                 510         


Leu Pro His Glu Leu Gly Asp Phe Ala Ala Leu Leu His Ala Gly Leu 
        515                 520                 525             


Ser Val Arg Gln Ala Leu Leu Leu Asn Leu Ala Ser Ala Leu Thr Ala 
    530                 535                 540                 


Phe Ala Gly Leu Tyr Val Ala Leu Ala Val Gly Val Ser Glu Glu Ser 
545                 550                 555                 560 


Glu Ala Trp Ile Leu Ala Val Ala Thr Gly Leu Phe Leu Tyr Val Ala 
                565                 570                 575     


Leu Cys Asp Met Leu Pro Ala Met Leu Lys Val Arg Asp Pro Arg Pro 
            580                 585                 590         


Trp Leu Leu Phe Leu Leu His Asn Val Gly Leu Leu Gly Gly Trp Thr 
        595                 600                 605             


Val Leu Leu Leu Leu Ser Leu Tyr Glu Asp Asp Ile Thr Phe 
    610                 615                 620         


<210>  4340
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  4340

Met Glu His Leu Lys Ala Phe Asp Asp Glu Ile Asn Ala Phe Leu Asp 
1               5                   10                  15      


Asn Met Phe Gly Pro Arg Asp Ser Arg Val Arg Gly Trp Phe Met Leu 
            20                  25                  30          


Asp Ser Tyr Leu Pro Thr Phe Phe Leu Thr Val Met Tyr Leu Leu Ser 
        35                  40                  45              


Ile Trp Leu Gly Asn Lys Tyr Met Lys Asn Arg Pro Ala Leu Ser Leu 
    50                  55                  60                  


Arg Gly Ile Leu Thr Leu Tyr Asn Leu Gly Ile Thr Leu Leu Ser Ala 
65                  70                  75                  80  


Tyr Met Leu Ala Glu Leu Ile Leu Ser Thr Trp Glu Gly Gly Tyr Asn 
                85                  90                  95      


Leu Gln Cys Gln Asp Leu Thr Ser Ala Gly Glu Ala Asp Ile Arg Val 
            100                 105                 110         


Ala Lys Val Leu Trp Trp Tyr Tyr Phe Ser Lys Ser Val Glu Phe Leu 
        115                 120                 125             


Asp Thr Ile Phe Phe Val Leu Arg Lys Lys Thr Ser Gln Ile Thr Phe 
    130                 135                 140                 


Leu His Val Tyr His His Ala Ser Met Phe Asn Ile Trp Trp Cys Val 
145                 150                 155                 160 


Leu Asn Trp Ile Pro Cys Gly Gln Ser Phe Phe Gly Pro Thr Leu Asn 
                165                 170                 175     


Ser Phe Ile His Ile Leu Met Tyr Ser Tyr Tyr Gly Leu Ser Val Phe 
            180                 185                 190         


Pro Ser Met His Lys Tyr Leu Trp Trp Lys Lys Tyr Leu Thr Gln Ala 
        195                 200                 205             


Gln Leu Val Gln Phe Val Leu Thr Ile Thr His Thr Met Ser Ala Val 
    210                 215                 220                 


Val Lys Pro Cys Gly Phe Pro Phe Gly Cys Leu Ile Phe Gln Ser Ser 
225                 230                 235                 240 


Tyr Met Leu Thr Leu Val Ile Leu Phe Leu Asn Phe Tyr Val Gln Thr 
                245                 250                 255     


Tyr Arg Lys Lys Pro Met Lys Lys Asp Met Gln Glu Pro Pro Ala Gly 
            260                 265                 270         


Lys Glu Val Lys Asn Gly Phe Ser Lys Ala Tyr Phe Thr Ala Ala Asn 
        275                 280                 285             


Gly Val Met Asn Lys Lys Ala Gln 
    290                 295     


<210>  4341
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  4341

Met Pro Ser Ala Ser Cys Asp Thr Leu Leu Asp Asp Ile Glu Asp Ile 
1               5                   10                  15      


Val Ser Gln Glu Asp Ser Lys Pro Gln Asp Arg His Phe Val Arg Lys 
            20                  25                  30          


Asp Val Val Pro Lys Val Arg Arg Arg Asn Thr Gln Lys Tyr Leu Gln 
        35                  40                  45              


Glu Glu Glu Asn Ser Pro Pro Ser Asp Ser Thr Ile Pro Gly Ile Gln 
    50                  55                  60                  


Lys Ile Trp Ile Arg Thr Trp Gly Cys Ser His Asn Asn Ser Asp Gly 
65                  70                  75                  80  


Glu Tyr Met Ala Gly Gln Leu Ala Ala Tyr Gly Tyr Lys Ile Thr Glu 
                85                  90                  95      


Asn Ala Ser Asp Ala Asp Leu Trp Leu Leu Asn Ser Cys Thr Val Lys 
            100                 105                 110         


Asn Pro Ala Glu Asp His Phe Arg Asn Ser Ile Lys Lys Ala Gln Glu 
        115                 120                 125             


Glu Asn Lys Lys Ile Val Leu Ala Gly Cys Val Pro Gln Ala Gln Pro 
    130                 135                 140                 


Arg Gln Asp Tyr Leu Lys Gly Leu Ser Ile Ile Gly Val Gln Gln Ile 
145                 150                 155                 160 


Asp Arg Val Val Glu Val Val Glu Glu Thr Ile Lys Gly His Ser Val 
                165                 170                 175     


Arg Leu Leu Gly Gln Lys Lys Asp Asn Gly Arg Arg Leu Gly Gly Ala 
            180                 185                 190         


Arg Leu Asp Leu Pro Lys Ile Arg Lys Asn Pro Leu Ile Glu Ile Ile 
        195                 200                 205             


Ser Ile Asn Thr Gly Cys Leu Asn Ala Cys Thr Tyr Cys Lys Thr Lys 
    210                 215                 220                 


His Ala Arg Gly Asn Leu Ala Ser Tyr Pro Ile Asp Glu Leu Val Asp 
225                 230                 235                 240 


Arg Ala Lys Gln Ser Phe Gln Glu Gly Val Cys Glu Ile Trp Leu Thr 
                245                 250                 255     


Ser Glu Asp Thr Gly Ala Tyr Gly Arg Asp Ile Gly Thr Asn Leu Pro 
            260                 265                 270         


Thr Leu Leu Trp Lys Leu Val Glu Val Ile Pro Glu Gly Ala Met Leu 
        275                 280                 285             


Arg Leu Gly Met Thr Asn Pro Pro Tyr Ile Leu Glu His Leu Glu Glu 
    290                 295                 300                 


Met Ala Lys Ile Leu Asn His Pro Arg Val Tyr Ala Phe Leu His Ile 
305                 310                 315                 320 


Pro Val Gln Ser Ala Ser Asp Ser Val Leu Met Glu Met Lys Arg Glu 
                325                 330                 335     


Tyr Cys Val Ala Asp Phe Lys Arg Val Val Asp Phe Leu Lys Glu Lys 
            340                 345                 350         


Val Pro Gly Ile Thr Ile Ala Thr Asp Ile Ile Cys Gly Phe Pro Gly 
        355                 360                 365             


Glu Thr Asp Gln Asp Phe Gln Glu Thr Val Lys Leu Val Glu Glu Tyr 
    370                 375                 380                 


Lys Phe Pro Ser Leu Phe Ile Asn Gln Phe Tyr Pro Arg Pro Gly Thr 
385                 390                 395                 400 


Pro Ala Ala Lys Met Glu Gln Val Pro Ala Gln Val Lys Lys Gln Arg 
                405                 410                 415     


Thr Lys Asp Leu Ser Arg Val Phe His Ser Tyr Ser Pro Tyr Asp His 
            420                 425                 430         


Lys Ile Gly Glu Arg Gln Gln Val Leu Val Thr Glu Glu Ser Phe Asp 
        435                 440                 445             


Ser Lys Phe Tyr Val Ala His Asn Gln Phe Tyr Glu Gln Val Leu Val 
    450                 455                 460                 


Pro Lys Asn Pro Ala Phe Met Gly Lys Met Val Glu Val Asp Ile Tyr 
465                 470                 475                 480 


Glu Ser Gly Lys His Phe Met Lys Gly Gln Pro Val Ser Asp Ala Lys 
                485                 490                 495     


Val Tyr Thr Pro Ser Ile Ser Lys Pro Leu Ala Lys Gly Glu Val Ser 
            500                 505                 510         


Gly Leu Thr Lys Asp Phe Arg Asn Gly Leu Gly Asn Gln Leu Ser Ser 
        515                 520                 525             


Gly Ser His Thr Ser Ala Ala Ser Gln Cys Asp Ser Ala Ser Ser Arg 
    530                 535                 540                 


Met Val Leu Pro Met Pro Arg Leu His Gln Asp Cys Ala Leu Arg Met 
545                 550                 555                 560 


Ser Val Gly Leu Ala Leu Leu Gly Leu Leu Phe Ala Phe Phe Val Lys 
                565                 570                 575     


Val Tyr Asn 
            


<210>  4342
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  4342

Met Pro Phe Leu Leu Gly Leu Arg Gln Asp Lys Glu Ala Cys Val Gly 
1               5                   10                  15      


Thr Asn Asn Gln Ser Tyr Ile Cys Asp Thr Gly His Cys Cys Gly Gln 
            20                  25                  30          


Ser Gln Cys Cys Asn Tyr Tyr Tyr Glu Leu Trp Trp Phe Trp Leu Val 
        35                  40                  45              


Trp Thr Ile Ile Ile Ile Leu Ser Cys Cys Cys Val Cys His His Arg 
    50                  55                  60                  


Arg Ala Lys His Arg Leu Gln Ala Gln Gln Arg Gln His Glu Ile Asn 
65                  70                  75                  80  


Leu Ile Ala Tyr Arg Glu Ala His Asn Tyr Ser Ala Leu Pro Phe Tyr 
                85                  90                  95      


Phe Arg Phe Leu Pro Asn Tyr Leu Leu Pro Pro Tyr Glu Glu Val Val 
            100                 105                 110         


Asn Arg Pro Pro Thr Pro Pro Pro Pro Tyr Ser Ala Phe Gln Leu Gln 
        115                 120                 125             


Gln Gln Gln Leu Leu Pro Pro Gln Cys Gly Pro Ala Gly Gly Ser Pro 
    130                 135                 140                 


Pro Gly Ile Asp Pro Thr Arg Gly Ser Gln Gly Ala Gln Ser Ser Pro 
145                 150                 155                 160 


Leu Ser Glu Pro Ser Arg Ser Ser Thr Arg Pro Pro Ser Ile Ala Asp 
                165                 170                 175     


Pro Asp Pro Ser Asp Leu Pro Val Asp Arg Ala Ala Thr Lys Ala Pro 
            180                 185                 190         


Gly Met Glu Pro Ser Gly Ser Val Ala Gly Leu Gly Glu Leu Asp Pro 
        195                 200                 205             


Gly Ala Phe Leu Asp Lys Asp Ala Glu Cys Arg Glu Glu Leu Leu Lys 
    210                 215                 220                 


Asp Asp Ser Ser Glu His Gly Ala Pro Asp Ser Lys Glu Lys Thr Pro 
225                 230                 235                 240 


Gly Arg His Arg Arg Phe Thr Gly Asp Ser Gly Ile Glu Val Cys Val 
                245                 250                 255     


Cys Asn Arg Gly His His Asp Asp Asp Leu Lys Glu Phe Asn Thr Leu 
            260                 265                 270         


Ile Asp Asp Ala Leu Asp Gly Pro Leu Asp Phe Cys Asp Ser Cys His 
        275                 280                 285             


Val Arg Pro Pro Gly Asp Glu Glu Glu Gly Leu Cys Gln Ser Ser Glu 
    290                 295                 300                 


Glu Gln Ala Arg Glu Pro Gly His Pro His Leu Pro Arg Pro Pro Ala 
305                 310                 315                 320 


Cys Leu Leu Leu Asn Thr Ile Asn Glu Gln Asp Ser Pro Asn Ser Gln 
                325                 330                 335     


Ser Ser Ser Ser Pro Ser 
            340         


<210>  4343
<211>  833
<212>  PRT
<213>  Homo sapiens

<400>  4343

Met Ala Pro His Trp Ala Val Trp Leu Leu Ala Ala Arg Leu Trp Gly 
1               5                   10                  15      


Leu Gly Ile Gly Ala Glu Val Trp Trp Asn Leu Val Pro Arg Lys Thr 
            20                  25                  30          


Val Ser Ser Gly Glu Leu Ala Thr Val Val Arg Arg Phe Ser Gln Thr 
        35                  40                  45              


Gly Ile Gln Asp Phe Leu Thr Leu Thr Leu Thr Glu Pro Thr Gly Leu 
    50                  55                  60                  


Leu Tyr Val Gly Ala Arg Glu Ala Leu Phe Ala Phe Ser Met Glu Ala 
65                  70                  75                  80  


Leu Glu Leu Gln Gly Ala Ile Ser Trp Glu Ala Pro Val Glu Lys Lys 
                85                  90                  95      


Thr Glu Cys Ile Gln Lys Gly Lys Asn Asn Gln Thr Glu Cys Phe Asn 
            100                 105                 110         


Phe Ile Arg Phe Leu Gln Pro Tyr Asn Ala Ser His Leu Tyr Val Cys 
        115                 120                 125             


Gly Thr Tyr Ala Phe Gln Pro Lys Cys Thr Tyr Val Asn Met Leu Thr 
    130                 135                 140                 


Phe Thr Leu Glu His Gly Glu Phe Glu Asp Gly Lys Gly Lys Cys Pro 
145                 150                 155                 160 


Tyr Asp Pro Ala Lys Gly His Ala Gly Leu Leu Val Asp Gly Glu Leu 
                165                 170                 175     


Tyr Ser Ala Thr Leu Asn Asn Phe Leu Gly Thr Glu Pro Ile Ile Leu 
            180                 185                 190         


Arg Asn Met Gly Pro His His Ser Met Lys Thr Glu Tyr Leu Ala Phe 
        195                 200                 205             


Trp Leu Asn Glu Pro His Phe Val Gly Ser Ala Tyr Val Pro Glu Ser 
    210                 215                 220                 


Val Gly Ser Phe Thr Gly Asp Asp Asp Lys Val Tyr Phe Phe Phe Arg 
225                 230                 235                 240 


Glu Arg Ala Val Glu Ser Asp Cys Tyr Ala Glu Gln Val Val Ala Arg 
                245                 250                 255     


Val Ala Arg Val Cys Lys Gly Asp Met Gly Gly Ala Arg Thr Leu Gln 
            260                 265                 270         


Arg Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu Ala Cys Ser Ala Pro 
        275                 280                 285             


Asn Trp Gln Leu Tyr Phe Asn Gln Leu Gln Ala Met His Thr Leu Gln 
    290                 295                 300                 


Asp Thr Ser Trp His Asn Thr Thr Phe Phe Gly Val Phe Gln Ala Gln 
305                 310                 315                 320 


Trp Gly Asp Met Tyr Leu Ser Ala Ile Cys Glu Tyr Gln Leu Glu Glu 
                325                 330                 335     


Ile Gln Arg Val Phe Glu Gly Pro Tyr Lys Glu Tyr His Glu Glu Ala 
            340                 345                 350         


Gln Lys Trp Asp Arg Tyr Thr Asp Pro Val Pro Ser Pro Arg Pro Gly 
        355                 360                 365             


Ser Cys Ile Asn Asn Trp His Arg Arg His Gly Tyr Thr Ser Ser Leu 
    370                 375                 380                 


Glu Leu Pro Asp Asn Ile Leu Asn Phe Val Lys Lys His Pro Leu Met 
385                 390                 395                 400 


Glu Glu Gln Val Gly Pro Arg Trp Ser Arg Pro Leu Leu Val Lys Lys 
                405                 410                 415     


Gly Thr Asn Phe Thr His Leu Val Ala Asp Arg Val Thr Gly Leu Asp 
            420                 425                 430         


Gly Ala Thr Tyr Thr Val Leu Phe Ile Gly Thr Gly Asp Gly Trp Leu 
        435                 440                 445             


Leu Lys Ala Val Ser Leu Gly Pro Trp Val His Leu Ile Glu Glu Leu 
    450                 455                 460                 


Gln Leu Phe Asp Gln Glu Pro Met Arg Ser Leu Val Leu Ser Gln Ser 
465                 470                 475                 480 


Lys Lys Leu Leu Phe Ala Gly Ser Arg Ser Gln Leu Val Gln Leu Pro 
                485                 490                 495     


Val Ala Asp Cys Met Lys Tyr Arg Ser Cys Ala Asp Cys Val Leu Ala 
            500                 505                 510         


Arg Asp Pro Tyr Cys Ala Trp Ser Val Asn Thr Ser Arg Cys Val Ala 
        515                 520                 525             


Val Gly Gly His Ser Gly Ser Leu Leu Ile Gln His Val Met Thr Ser 
    530                 535                 540                 


Asp Thr Ser Gly Ile Cys Asn Leu Arg Gly Ser Lys Lys Val Arg Pro 
545                 550                 555                 560 


Thr Pro Lys Asn Ile Thr Val Val Ala Gly Thr Asp Leu Val Leu Pro 
                565                 570                 575     


Cys His Leu Ser Ser Asn Leu Ala His Ala Arg Trp Thr Phe Gly Gly 
            580                 585                 590         


Arg Asp Leu Pro Ala Glu Gln Pro Gly Ser Phe Leu Tyr Asp Ala Arg 
        595                 600                 605             


Leu Gln Ala Leu Val Val Met Ala Ala Gln Pro Arg His Ala Gly Ala 
    610                 615                 620                 


Tyr His Cys Phe Ser Glu Glu Gln Gly Ala Arg Leu Ala Ala Glu Gly 
625                 630                 635                 640 


Tyr Leu Val Ala Val Val Ala Gly Pro Ser Val Thr Leu Glu Ala Arg 
                645                 650                 655     


Ala Pro Leu Glu Asn Leu Gly Leu Val Trp Leu Ala Val Val Ala Leu 
            660                 665                 670         


Gly Ala Val Cys Leu Val Leu Leu Leu Leu Val Leu Ser Leu Arg Arg 
        675                 680                 685             


Arg Leu Arg Glu Glu Leu Glu Lys Gly Ala Lys Ala Thr Glu Arg Thr 
    690                 695                 700                 


Leu Val Tyr Pro Leu Glu Leu Pro Lys Glu Pro Thr Ser Pro Pro Phe 
705                 710                 715                 720 


Arg Pro Cys Pro Glu Pro Asp Glu Lys Leu Trp Asp Pro Val Gly Tyr 
                725                 730                 735     


Tyr Tyr Ser Asp Gly Ser Leu Lys Ile Val Pro Gly His Ala Arg Cys 
            740                 745                 750         


Gln Pro Gly Gly Gly Pro Pro Ser Pro Pro Pro Gly Ile Pro Gly Gln 
        755                 760                 765             


Pro Leu Pro Ser Pro Thr Arg Leu His Leu Gly Gly Gly Arg Asn Ser 
    770                 775                 780                 


Asn Ala Asn Gly Tyr Val Arg Leu Gln Leu Gly Gly Glu Asp Arg Gly 
785                 790                 795                 800 


Gly Leu Gly His Pro Leu Pro Glu Leu Ala Asp Glu Leu Arg Arg Lys 
                805                 810                 815     


Leu Gln Gln Arg Gln Pro Leu Pro Asp Ser Asn Pro Glu Glu Ser Ser 
            820                 825                 830         


Val 
    


<210>  4344
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  4344

Met Val Asn Glu Gly Pro Asn Gln Glu Glu Ser Asp Asp Thr Pro Val 
1               5                   10                  15      


Pro Glu Ser Ala Leu Gln Ala Asp Pro Ser Val Ser Val His Pro Ser 
            20                  25                  30          


Val Ser Val His Pro Ser Val Ser Ile Asn Pro Ser Val Ser Val His 
        35                  40                  45              


Pro Ser Ser Ser Ala His Pro Ser Ala Leu Ala Gln Pro Ser Gly Leu 
    50                  55                  60                  


Ala His Pro Ser Ser Ser Gly Pro Glu Asp Leu Ser Val Ile Lys Val 
65                  70                  75                  80  


Ser Arg Arg Arg Trp Ala Val Val Leu Val Phe Ser Cys Tyr Ser Met 
                85                  90                  95      


Cys Asn Ser Phe Gln Trp Ile Gln Tyr Gly Ser Ile Asn Asn Ile Phe 
            100                 105                 110         


Met His Phe Tyr Gly Val Ser Ala Phe Ala Ile Asp Trp Leu Ser Met 
        115                 120                 125             


Cys Tyr Met Leu Thr Tyr Ile Pro Leu Leu Leu Pro Val Ala Trp Leu 
    130                 135                 140                 


Leu Glu Lys Phe Gly Leu Arg Thr Ile Ala Leu Thr Gly Ser Ala Leu 
145                 150                 155                 160 


Asn Cys Leu Gly Ala Trp Val Lys Leu Gly Ser Leu Lys Pro His Leu 
                165                 170                 175     


Phe Pro Val Thr Val Val Gly Gln Leu Ile Cys Ser Val Ala Gln Val 
            180                 185                 190         


Phe Ile Leu Gly Met Pro Ser Arg Ile Ala Ser Val Trp Phe Gly Ala 
        195                 200                 205             


Asn Glu Val Ser Thr Ala Cys Ser Val Ala Val Phe Gly Asn Gln Leu 
    210                 215                 220                 


Gly Ile Ala Ile Gly Phe Leu Val Pro Pro Val Leu Val Pro Asn Ile 
225                 230                 235                 240 


Glu Asp Arg Asp Glu Leu Ala Tyr His Ile Ser Ile Met Phe Tyr Ile 
                245                 250                 255     


Ile Gly Gly Val Ala Thr Leu Leu Leu Ile Leu Val Ile Ile Val Phe 
            260                 265                 270         


Lys Glu Lys Pro Lys Tyr Pro Pro Ser Arg Ala Gln Ser Leu Ser Tyr 
        275                 280                 285             


Ala Leu Thr Ser Pro Asp Ala Ser Tyr Leu Gly Ser Ile Ala Arg Leu 
    290                 295                 300                 


Phe Lys Asn Leu Asn Phe Val Leu Leu Val Ile Thr Tyr Gly Leu Asn 
305                 310                 315                 320 


Ala Gly Ala Phe Tyr Ala Leu Ser Thr Leu Leu Asn Arg Met Val Ile 
                325                 330                 335     


Trp His Tyr Pro Gly Glu Glu Val Asn Ala Gly Arg Ile Gly Leu Thr 
            340                 345                 350         


Ile Val Ile Ala Gly Met Leu Gly Ala Val Ile Ser Gly Ile Trp Leu 
        355                 360                 365             


Asp Arg Ser Lys Thr Tyr Lys Glu Thr Thr Leu Val Val Tyr Ile Met 
    370                 375                 380                 


Thr Leu Val Gly Met Val Val Tyr Thr Phe Thr Leu Asn Leu Gly His 
385                 390                 395                 400 


Leu Trp Val Val Phe Ile Thr Ala Gly Thr Met Gly Phe Phe Met Thr 
                405                 410                 415     


Gly Tyr Leu Pro Leu Gly Phe Glu Phe Ala Val Glu Leu Thr Tyr Pro 
            420                 425                 430         


Glu Ser Glu Gly Ile Ser Ser Gly Leu Leu Asn Ile Ser Ala Gln Val 
        435                 440                 445             


Phe Gly Ile Ile Phe Thr Ile Ser Gln Gly Gln Ile Ile Asp Asn Tyr 
    450                 455                 460                 


Gly Thr Lys Pro Gly Asn Ile Phe Leu Cys Val Phe Leu Thr Leu Gly 
465                 470                 475                 480 


Ala Ala Leu Thr Ala Phe Ile Lys Ala Asp Leu Arg Arg Gln Lys Ala 
                485                 490                 495     


Asn Lys Glu Thr Leu Glu Asn Lys Leu Gln Glu Glu Glu Glu Glu Ser 
            500                 505                 510         


Asn Thr Ser Lys Val Pro Thr Ala Val Ser Glu Asp His Leu 
        515                 520                 525     


<210>  4345
<211>  707
<212>  PRT
<213>  Homo sapiens

<400>  4345

Met Ser Pro His Gly Asp Gly Arg Gly Gln Ala Gln Gly Arg Ala Val 
1               5                   10                  15      


Arg Val Gly Leu Arg Arg Ser Gly Gly Ile Arg Gly Gly Val Ala Val 
            20                  25                  30          


Phe Ala Ala Val Ala Ala Val Phe Thr Phe Thr Leu Pro Pro Ser Val 
        35                  40                  45              


Pro Gly Gly Asp Ser Gly Glu Leu Ile Thr Ala Ala His Glu Leu Gly 
    50                  55                  60                  


Val Ala His Pro Pro Gly Tyr Pro Leu Phe Thr Leu Val Ala Lys Leu 
65                  70                  75                  80  


Ala Ile Thr Leu Phe Pro Phe Gly Ser Ile Ala Tyr Arg Val Asn Leu 
                85                  90                  95      


Leu Cys Gly Leu Phe Gly Ala Val Ala Ala Ser Leu Leu Phe Phe Thr 
            100                 105                 110         


Val Phe Arg Leu Ser Gly Ser Ser Ala Gly Gly Ile Leu Ala Ala Gly 
        115                 120                 125             


Val Phe Ser Phe Ser Arg Leu Thr Trp Gln Trp Ser Ile Ala Ala Glu 
    130                 135                 140                 


Val Phe Ser Leu Asn Asn Leu Phe Val Gly Leu Leu Met Ala Leu Thr 
145                 150                 155                 160 


Val His Phe Glu Glu Ala Ala Thr Ala Lys Glu Arg Ser Lys Val Ala 
                165                 170                 175     


Lys Ile Gly Ala Phe Cys Cys Gly Leu Ser Leu Cys Asn Gln His Thr 
            180                 185                 190         


Ile Ile Leu Tyr Val Leu Cys Ile Ile Pro Trp Ile Leu Phe Gln Leu 
        195                 200                 205             


Leu Lys Lys Lys Glu Leu Ser Leu Gly Ser Leu Leu Lys Leu Ser Leu 
    210                 215                 220                 


Tyr Phe Ser Ala Gly Leu Leu Pro Tyr Val His Leu Pro Ile Ser Ser 
225                 230                 235                 240 


Tyr Leu Asn His Ala Arg Trp Thr Trp Gly Asp Gln Thr Thr Leu Gln 
                245                 250                 255     


Gly Phe Leu Thr His Phe Leu Arg Glu Glu Tyr Gly Thr Phe Ser Leu 
            260                 265                 270         


Ala Lys Ser Glu Ile Gly Ser Ser Met Ser Glu Ile Leu Leu Ser Gln 
        275                 280                 285             


Val Thr Asn Met Arg Thr Glu Leu Ser Phe Asn Ile Gln Ala Leu Ala 
    290                 295                 300                 


Val Cys Ala Asn Ile Cys Leu Ala Thr Lys Asp Arg Gln Asn Pro Ser 
305                 310                 315                 320 


Leu Val Trp Leu Phe Thr Gly Met Phe Cys Ile Tyr Ser Leu Phe Phe 
                325                 330                 335     


Ala Trp Arg Ala Asn Leu Asp Ile Ser Lys Pro Leu Phe Met Gly Val 
            340                 345                 350         


Val Glu Arg Phe Trp Met Gln Ser Asn Ala Val Val Ala Val Leu Ala 
        355                 360                 365             


Gly Ile Gly Leu Ala Ala Val Val Ser Glu Thr Asn Arg Val Leu Asn 
    370                 375                 380                 


Ser Asn Gly Leu Gln Cys Leu Glu Trp Leu Ser Ala Thr Leu Phe Val 
385                 390                 395                 400 


Val Tyr Gln Ile Tyr Ser Asn Tyr Ser Val Cys Asp Gln Arg Thr Asn 
                405                 410                 415     


Tyr Val Ile Asp Lys Phe Ala Lys Asn Leu Leu Thr Ser Met Pro His 
            420                 425                 430         


Asp Ala Ile Ile Leu Leu Arg Gly Asp Leu Pro Gly Asn Ser Leu Arg 
        435                 440                 445             


Tyr Met His Tyr Cys Glu Gly Leu Arg Pro Asp Ile Ser Leu Val Asp 
    450                 455                 460                 


Gln Glu Met Met Thr Tyr Glu Trp Tyr Leu Pro Lys Met Ala Lys His 
465                 470                 475                 480 


Leu Pro Gly Val Asn Phe Pro Gly Asn Arg Trp Asn Pro Val Glu Gly 
                485                 490                 495     


Ile Leu Pro Ser Gly Met Val Thr Phe Asn Leu Tyr His Phe Leu Glu 
            500                 505                 510         


Val Asn Lys Gln Lys Glu Thr Phe Val Cys Ile Gly Ile His Glu Gly 
        515                 520                 525             


Asp Pro Thr Trp Lys Lys Asn Tyr Ser Leu Trp Pro Trp Gly Ser Cys 
    530                 535                 540                 


Asp Lys Leu Val Pro Leu Glu Ile Val Phe Asn Pro Glu Glu Trp Ile 
545                 550                 555                 560 


Lys Leu Thr Lys Ser Ile Tyr Asn Trp Thr Glu Glu Tyr Gly Arg Phe 
                565                 570                 575     


Asp Pro Ser Ser Trp Glu Ser Val Ala Asn Glu Glu Met Trp Gln Ala 
            580                 585                 590         


Arg Met Lys Thr Pro Phe Phe Ile Phe Asn Leu Ala Glu Thr Ala His 
        595                 600                 605             


Met Pro Ser Lys Val Lys Ala Gln Leu Tyr Ala Gln Ala Tyr Asp Leu 
    610                 615                 620                 


Tyr Lys Glu Ile Val Tyr Leu Gln Lys Glu His Pro Val Asn Trp His 
625                 630                 635                 640 


Lys Asn Tyr Ala Ile Ala Cys Glu Arg Met Leu Arg Leu Gln Ala Arg 
                645                 650                 655     


Asp Ala Asp Pro Glu Val Leu Leu Ser Glu Thr Ile Arg His Phe Arg 
            660                 665                 670         


Leu Tyr Ser Gln Lys Ala Pro Asn Asp Pro Gln Gln Ala Asp Ile Leu 
        675                 680                 685             


Gly Ala Leu Lys His Leu Arg Lys Glu Leu Gln Ser Leu Arg Asn Arg 
    690                 695                 700                 


Lys Asn Val 
705         


<210>  4346
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  4346

Met Glu Asn Gly Ala Val Tyr Ser Pro Thr Thr Glu Glu Asp Pro Gly 
1               5                   10                  15      


Pro Ala Arg Gly Pro Arg Ser Gly Leu Ala Ala Tyr Phe Phe Met Gly 
            20                  25                  30          


Arg Leu Pro Leu Leu Arg Arg Val Leu Lys Gly Leu Gln Leu Leu Leu 
        35                  40                  45              


Ser Leu Leu Ala Phe Ile Cys Glu Glu Val Val Ser Gln Cys Thr Leu 
    50                  55                  60                  


Cys Gly Gly Leu Tyr Phe Phe Glu Phe Val Ser Cys Ser Ala Phe Leu 
65                  70                  75                  80  


Leu Ser Leu Leu Ile Leu Ile Val Tyr Cys Thr Pro Phe Tyr Glu Arg 
                85                  90                  95      


Val Asp Thr Thr Lys Val Lys Ser Ser Asp Phe Tyr Ile Thr Leu Gly 
            100                 105                 110         


Thr Gly Cys Val Phe Leu Leu Ala Ser Ile Ile Phe Val Ser Thr His 
        115                 120                 125             


Asp Arg Thr Ser Ala Glu Ile Ala Ala Ile Val Phe Gly Phe Ile Ala 
    130                 135                 140                 


Ser Phe Met Phe Leu Leu Asp Phe Ile Thr Met Leu Tyr Glu Lys Arg 
145                 150                 155                 160 


Gln Glu Ser Gln Leu Arg Lys Pro Glu Asn Thr Thr Arg Ala Glu Ala 
                165                 170                 175     


Leu Thr Glu Pro Leu Asn Ala 
            180             


<210>  4347
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  4347

Met Ala Pro Met Gly Ile Arg Leu Ser Pro Leu Gly Val Ala Val Phe 
1               5                   10                  15      


Cys Leu Leu Gly Leu Gly Val Leu Tyr His Leu Tyr Ser Gly Phe Leu 
            20                  25                  30          


Ala Gly Arg Phe Ser Leu Phe Gly Leu Gly Gly Glu Pro Gly Gly Gly 
        35                  40                  45              


Ala Ala Gly Pro Ala Ala Ala Ala Asp Gly Gly Thr Val Asp Leu Arg 
    50                  55                  60                  


Glu Met Leu Ala Val Ser Val Leu Ala Ala Val Arg Gly Gly Asp Glu 
65                  70                  75                  80  


Val Arg Arg Val Arg Glu Ser Asn Val Leu His Glu Lys Ser Lys Gly 
                85                  90                  95      


Lys Thr Arg Glu Gly Ala Glu Asp Lys Met Thr Ser Gly Asp Val Leu 
            100                 105                 110         


Ser Asn Arg Lys Met Phe Tyr Leu Leu Lys Thr Ala Phe Pro Ser Val 
        115                 120                 125             


Gln Ile Asn Thr Glu Glu His Val Asp Ala Ala Asp Gln Glu Val Ile 
    130                 135                 140                 


Leu Trp Asp His Lys Ile Pro Glu Asp Ile Leu Lys Glu Val Thr Thr 
145                 150                 155                 160 


Pro Lys Glu Val Pro Ala Glu Ser Val Thr Val Trp Ile Asp Pro Leu 
                165                 170                 175     


Asp Ala Thr Gln Glu Tyr Thr Glu Asp Leu Arg Lys Tyr Val Thr Thr 
            180                 185                 190         


Met Val Cys Val Ala Val Asn Gly Lys Pro Met Leu Gly Val Ile His 
        195                 200                 205             


Lys Pro Phe Ser Glu Tyr Thr Ala Trp Ala Met Val Asp Gly Gly Ser 
    210                 215                 220                 


Asn Val Lys Ala Arg Ser Ser Tyr Asn Glu Lys Thr Pro Arg Ile Val 
225                 230                 235                 240 


Val Ser Arg Ser His Ser Gly Met Val Lys Gln Val Ala Leu Gln Thr 
                245                 250                 255     


Phe Gly Asn Gln Thr Thr Ile Ile Pro Ala Gly Gly Ala Gly Tyr Lys 
            260                 265                 270         


Val Leu Ala Leu Leu Asp Val Pro Asp Lys Ser Gln Glu Lys Ala Asp 
        275                 280                 285             


Leu Tyr Ile His Val Thr Tyr Ile Lys Lys Trp Asp Ile Cys Ala Gly 
    290                 295                 300                 


Asn Ala Ile Leu Lys Ala Leu Gly Gly His Met Thr Thr Leu Ser Gly 
305                 310                 315                 320 


Glu Glu Ile Ser Tyr Thr Gly Ser Asp Gly Ile Glu Gly Gly Leu Leu 
                325                 330                 335     


Ala Ser Ile Arg Met Asn His Gln Ala Leu Val Arg Lys Leu Pro Asp 
            340                 345                 350         


Leu Glu Lys Thr Gly His Lys 
        355                 


<210>  4348
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  4348

Met Ala Val Leu Gly Val Gln Leu Val Val Thr Leu Leu Thr Ala Thr 
1               5                   10                  15      


Leu Met His Arg Leu Ala Pro His Cys Ser Phe Ala Arg Trp Leu Leu 
            20                  25                  30          


Cys Asn Gly Ser Leu Phe Arg Tyr Lys His Pro Ser Glu Glu Glu Leu 
        35                  40                  45              


Arg Ala Leu Ala Gly Lys Pro Arg Pro Arg Gly Arg Lys Glu Arg Trp 
    50                  55                  60                  


Ala Asn Gly Leu Ser Glu Glu Lys Pro Leu Ser Val Pro Arg Asp Ala 
65                  70                  75                  80  


Pro Phe Gln Leu Glu Thr Cys Pro Leu Thr Thr Val Asp Ala Leu Val 
                85                  90                  95      


Leu Arg Phe Phe Leu Glu Tyr Gln Trp Phe Val Asp Phe Ala Val Tyr 
            100                 105                 110         


Ser Gly Gly Val Tyr Leu Phe Thr Glu Ala Tyr Tyr Tyr Met Leu Gly 
        115                 120                 125             


Pro Ala Lys Glu Thr Asn Ile Ala Val Phe Trp Cys Leu Leu Thr Val 
    130                 135                 140                 


Thr Phe Ser Ile Lys Met Phe Leu Thr Val Thr Arg Leu Tyr Phe Ser 
145                 150                 155                 160 


Ala Glu Glu Gly Gly Glu Arg Ser Val Cys Leu Thr Phe Ala Phe Leu 
                165                 170                 175     


Phe Leu Leu Leu Ala Met Leu Val Gln Val Val Arg Glu Glu Thr Leu 
            180                 185                 190         


Glu Leu Gly Leu Glu Pro Gly Leu Ala Ser Met Thr Gln Asn Leu Glu 
        195                 200                 205             


Pro Leu Leu Lys Lys Gln Gly Trp Asp Trp Ala Leu Pro Val Ala Lys 
    210                 215                 220                 


Leu Ala Ile Arg Val Gly Leu Ala Val Val Gly Ser Val Leu Gly Ala 
225                 230                 235                 240 


Phe Leu Thr Phe Pro Gly Leu Arg Leu Ala Gln Thr His Arg Asp Ala 
                245                 250                 255     


Leu Thr Met Ser Glu Asp Arg Pro Met Leu Gln Phe Leu Leu His Thr 
            260                 265                 270         


Ser Phe Leu Ser Pro Leu Phe Ile Leu Trp Leu Trp Thr Lys Pro Ile 
        275                 280                 285             


Ala Arg Asp Phe Leu His Gln Pro Pro Phe Gly Glu Thr Arg Phe Ser 
    290                 295                 300                 


Leu Leu Ser Asp Ser Ala Phe Asp Ser Gly Arg Leu Trp Leu Leu Val 
305                 310                 315                 320 


Val Leu Cys Leu Leu Arg Leu Ala Val Thr Arg Pro His Leu Gln Ala 
                325                 330                 335     


Tyr Leu Cys Leu Ala Lys Ala Arg Val Glu Gln Leu Arg Arg Glu Ala 
            340                 345                 350         


Gly Arg Ile Glu Ala Arg Glu Ile Gln Gln Arg Val Val Arg Val Tyr 
        355                 360                 365             


Cys Tyr Val Thr Val Val Ser Leu Gln Tyr Leu Thr Pro Leu Ile Leu 
    370                 375                 380                 


Thr Leu Asn Cys Thr Leu Leu Leu Lys Thr Leu Gly Gly Tyr Ser Trp 
385                 390                 395                 400 


Gly Leu Gly Pro Ala Pro Leu Leu Ser Pro Asp Pro Ser Ser Ala Ser 
                405                 410                 415     


Ala Ala Pro Ile Gly Ser Gly Glu Asp Glu Val Gln Gln Thr Ala Ala 
            420                 425                 430         


Arg Ile Ala Gly Ala Leu Gly Gly Leu Leu Thr Pro Leu Phe Leu Arg 
        435                 440                 445             


Gly Val Leu Ala Tyr Leu Ile Trp Trp Thr Ala Ala Cys Gln Leu Leu 
    450                 455                 460                 


Ala Ser Leu Phe Gly Leu Tyr Phe His Gln His Leu Ala Gly Ser 
465                 470                 475                 


<210>  4349
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  4349

Met Ala Ala Val His Asp Leu Glu Met Glu Ser Met Asn Leu Asn Met 
1               5                   10                  15      


Gly Arg Glu Met Lys Glu Glu Leu Glu Glu Glu Glu Lys Met Arg Glu 
            20                  25                  30          


Asp Gly Gly Gly Lys Asp Arg Ala Lys Ser Lys Lys Val His Arg Ile 
        35                  40                  45              


Val Ser Lys Trp Met Leu Pro Glu Lys Ser Arg Gly Thr Tyr Leu Glu 
    50                  55                  60                  


Arg Ala Asn Cys Phe Pro Pro Pro Val Phe Ile Ile Ser Ile Ser Leu 
65                  70                  75                  80  


Ala Glu Leu Ala Val Phe Ile Tyr Tyr Ala Val Trp Lys Pro Gln Lys 
                85                  90                  95      


Gln Trp Ile Thr Leu Asp Thr Gly Ile Leu Glu Ser Pro Phe Ile Tyr 
            100                 105                 110         


Ser Pro Glu Lys Arg Glu Glu Ala Trp Arg Phe Ile Ser Tyr Met Leu 
        115                 120                 125             


Val His Ala Gly Val Gln His Ile Leu Gly Asn Leu Cys Met Gln Leu 
    130                 135                 140                 


Val Leu Gly Ile Pro Leu Glu Met Val His Lys Gly Leu Arg Val Gly 
145                 150                 155                 160 


Leu Val Tyr Leu Ala Gly Val Ile Ala Gly Ser Leu Ala Ser Ser Ile 
                165                 170                 175     


Phe Asp Pro Leu Arg Tyr Leu Val Gly Ala Ser Gly Gly Val Tyr Ala 
            180                 185                 190         


Leu Met Gly Gly Tyr Phe Met Asn Val Leu Val Asn Phe Gln Glu Met 
        195                 200                 205             


Ile Pro Ala Phe Gly Ile Phe Arg Leu Leu Ile Ile Ile Leu Ile Ile 
    210                 215                 220                 


Val Leu Asp Met Gly Phe Ala Leu Tyr Arg Arg Phe Phe Val Pro Glu 
225                 230                 235                 240 


Asp Gly Ser Pro Val Ser Phe Ala Ala His Ile Ala Gly Gly Phe Ala 
                245                 250                 255     


Gly Met Ser Ile Gly Tyr Thr Val Phe Ser Cys Phe Asp Lys Ala Leu 
            260                 265                 270         


Leu Lys Asp Pro Arg Phe Trp Ile Ala Ile Ala Ala Tyr Leu Ala Cys 
        275                 280                 285             


Val Leu Phe Ala Val Phe Phe Asn Ile Phe Leu Ser Pro Ala Asn 
    290                 295                 300             


<210>  4350
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  4350

Met Pro Asp Gln Ala Leu Gln Gln Met Leu Asp Arg Ser Cys Trp Val 
1               5                   10                  15      


Cys Phe Ala Thr Asp Glu Asp Asp Arg Thr Ala Glu Trp Val Arg Pro 
            20                  25                  30          


Cys Arg Cys Arg Gly Ser Thr Lys Trp Val His Gln Ala Cys Leu Gln 
        35                  40                  45              


Arg Trp Val Asp Glu Lys Gln Arg Gly Asn Ser Thr Ala Arg Val Ala 
    50                  55                  60                  


Cys Pro Gln Cys Asn Ala Glu Tyr Leu Ile Val Phe Pro Lys Leu Gly 
65                  70                  75                  80  


Pro Val Val Tyr Val Leu Asp Leu Ala Asp Arg Leu Ile Ser Lys Ala 
                85                  90                  95      


Cys Pro Phe Ala Ala Ala Gly Ile Met Val Gly Ser Ile Tyr Trp Thr 
            100                 105                 110         


Ala Val Thr Tyr Gly Ala Val Thr Val Met Gln Val Val Gly His Lys 
        115                 120                 125             


Glu Gly Leu Asp Val Met Glu Arg Ala Asp Pro Leu Phe Leu Leu Ile 
    130                 135                 140                 


Gly Leu Pro Thr Ile Pro Val Met Leu Ile Leu Gly Lys Met Ile Arg 
145                 150                 155                 160 


Trp Glu Asp Tyr Val Leu Arg Leu Trp Arg Lys Tyr Ser Asn Lys Leu 
                165                 170                 175     


Gln Ile Leu Asn Ser Ile Phe Pro Gly Ile Gly Cys Pro Val Pro Arg 
            180                 185                 190         


Ile Pro Ala Glu Ala Asn Pro Leu Ala Asp His Val Ser Ala Thr Arg 
        195                 200                 205             


Ile Leu Cys Gly Ala Leu Val Phe Pro Thr Ile Ala Thr Ile Val Gly 
    210                 215                 220                 


Lys Leu Met Phe Ser Ser Val Asn Ser Asn Leu Gln Arg Thr Ile Leu 
225                 230                 235                 240 


Gly Gly Ile Ala Phe Val Ala Ile Lys Gly Ala Phe Lys Val Tyr Phe 
                245                 250                 255     


Lys Gln Gln Gln Tyr Leu Arg Gln Ala His Arg Lys Ile Leu Asn Tyr 
            260                 265                 270         


Pro Glu Gln Glu Glu Ala 
        275             


<210>  4351
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  4351

Met Asn Gly Arg Ala Asp Phe Arg Glu Pro Asn Ala Glu Val Pro Arg 
1               5                   10                  15      


Pro Ile Pro His Ile Gly Pro Asp Tyr Ile Pro Thr Glu Glu Glu Arg 
            20                  25                  30          


Arg Val Phe Ala Glu Cys Asn Asp Glu Ser Phe Trp Phe Arg Ser Val 
        35                  40                  45              


Pro Leu Ala Ala Thr Ser Met Leu Ile Thr Gln Gly Leu Ile Ser Lys 
    50                  55                  60                  


Gly Ile Leu Ser Ser His Pro Lys Tyr Gly Ser Ile Pro Lys Leu Ile 
65                  70                  75                  80  


Leu Ala Cys Ile Met Gly Tyr Phe Ala Gly Lys Leu Ser Tyr Val Lys 
                85                  90                  95      


Thr Cys Gln Glu Lys Phe Lys Lys Leu Glu Asn Ser Pro Leu Gly Glu 
            100                 105                 110         


Ala Leu Arg Ser Gly Gln Ala Arg Arg Ser Ser Pro Pro Gly His Tyr 
        115                 120                 125             


Tyr Gln Lys Ser Lys Tyr Asp Ser Ser Val Ser Gly Gln Ser Ser Phe 
    130                 135                 140                 


Val Thr Ser Pro Ala Ala Asp Asn Ile Glu Met Leu Pro His Tyr Glu 
145                 150                 155                 160 


Pro Ile Pro Phe Ser Ser Ser Met Asn Glu Ser Ala Pro Thr Gly Ile 
                165                 170                 175     


Thr Asp His Ile Val Gln Gly Pro Asp Pro Asn Leu Glu Glu Ser Pro 
            180                 185                 190         


Lys Arg Lys Asn Ile Thr Tyr Glu Glu Leu Arg Asn Lys Asn Arg Glu 
        195                 200                 205             


Ser Tyr Glu Val Ser Leu Thr Gln Lys Thr Asp Pro Ser Val Arg Pro 
    210                 215                 220                 


Met His Glu Arg Val Pro Lys Lys Glu Val Lys Val Asn Lys Tyr Gly 
225                 230                 235                 240 


Asp Thr Trp Asp Glu 
                245 


<210>  4352
<211>  487
<212>  PRT
<213>  Homo sapiens

<400>  4352

Met Asp Gly Thr Glu Thr Arg Gln Arg Arg Leu Asp Ser Cys Gly Lys 
1               5                   10                  15      


Pro Gly Glu Leu Gly Leu Pro His Pro Leu Ser Thr Gly Gly Leu Pro 
            20                  25                  30          


Val Ala Ser Glu Asp Gly Ala Leu Arg Ala Pro Glu Ser Gln Ser Val 
        35                  40                  45              


Thr Pro Lys Pro Leu Glu Thr Glu Pro Ser Arg Glu Thr Ala Trp Ser 
    50                  55                  60                  


Ile Gly Leu Gln Val Thr Val Pro Phe Met Phe Ala Gly Leu Gly Leu 
65                  70                  75                  80  


Ser Trp Ala Gly Met Leu Leu Asp Tyr Phe Gln His Trp Pro Val Phe 
                85                  90                  95      


Val Glu Val Lys Asp Leu Leu Thr Leu Val Pro Pro Leu Val Gly Leu 
            100                 105                 110         


Lys Gly Asn Leu Glu Met Thr Leu Ala Ser Arg Leu Ser Thr Ala Ala 
        115                 120                 125             


Asn Thr Gly Gln Ile Asp Asp Pro Gln Glu Gln His Arg Val Ile Ser 
    130                 135                 140                 


Ser Asn Leu Ala Leu Ile Gln Val Gln Ala Thr Val Val Gly Leu Leu 
145                 150                 155                 160 


Ala Ala Val Ala Ala Leu Leu Leu Gly Val Val Ser Arg Glu Glu Val 
                165                 170                 175     


Asp Val Ala Lys Val Glu Leu Leu Cys Ala Ser Ser Val Leu Thr Ala 
            180                 185                 190         


Phe Leu Ala Ala Phe Ala Leu Gly Val Leu Met Val Cys Ile Val Ile 
        195                 200                 205             


Gly Ala Arg Lys Leu Gly Val Asn Pro Asp Asn Ile Ala Thr Pro Ile 
    210                 215                 220                 


Ala Ala Ser Leu Gly Asp Leu Ile Thr Leu Ser Ile Leu Ala Leu Val 
225                 230                 235                 240 


Ser Ser Phe Phe Tyr Arg His Lys Asp Ser Arg Tyr Leu Thr Pro Leu 
                245                 250                 255     


Val Cys Leu Ser Phe Ala Ala Leu Thr Pro Val Trp Val Leu Ile Ala 
            260                 265                 270         


Lys Gln Ser Pro Pro Ile Val Lys Ile Leu Lys Phe Gly Trp Phe Pro 
        275                 280                 285             


Ile Ile Leu Ala Met Val Ile Ser Ser Phe Gly Gly Leu Ile Leu Ser 
    290                 295                 300                 


Lys Thr Val Ser Lys Gln Gln Tyr Lys Gly Met Ala Ile Phe Thr Pro 
305                 310                 315                 320 


Val Ile Cys Gly Val Gly Gly Asn Leu Val Ala Ile Gln Thr Ser Arg 
                325                 330                 335     


Ile Ser Thr Tyr Leu His Met Trp Ser Ala Pro Gly Val Leu Pro Leu 
            340                 345                 350         


Gln Met Lys Lys Phe Trp Pro Asn Pro Cys Ser Thr Phe Cys Thr Ser 
        355                 360                 365             


Glu Ile Asn Ser Met Ser Ala Arg Val Leu Leu Leu Leu Val Val Pro 
    370                 375                 380                 


Gly His Leu Ile Phe Phe Tyr Ile Ile Tyr Leu Val Glu Gly Gln Ser 
385                 390                 395                 400 


Val Ile Asn Ser Gln Thr Phe Val Val Leu Tyr Leu Leu Ala Gly Leu 
                405                 410                 415     


Ile Gln Val Thr Ile Leu Leu Tyr Leu Ala Glu Val Met Val Arg Leu 
            420                 425                 430         


Thr Trp His Gln Ala Leu Asp Pro Asp Asn His Cys Ile Pro Tyr Leu 
        435                 440                 445             


Thr Gly Leu Gly Asp Leu Leu Gly Thr Gly Leu Leu Ala Leu Cys Phe 
    450                 455                 460                 


Phe Thr Asp Trp Leu Leu Lys Ser Lys Ala Glu Leu Gly Gly Ile Ser 
465                 470                 475                 480 


Glu Leu Ala Ser Gly Pro Pro 
                485         


<210>  4353
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  4353

Met Trp Pro Gln Asp Pro Ser Arg Lys Glu Val Leu Arg Phe Ala Val 
1               5                   10                  15      


Ser Cys Arg Ile Leu Thr Leu Met Leu Gln Ala Leu Phe Asn Ala Ile 
            20                  25                  30          


Ile Pro Asp His His Ala Glu Ala Phe Ser Pro Pro Arg Leu Ala Pro 
        35                  40                  45              


Ser Gly Phe Val Asp Gln Leu Val Glu Gly Leu Leu Gly Gly Leu Ser 
    50                  55                  60                  


His Trp Asp Ala Glu His Phe Leu Phe Ile Ala Glu His Gly Tyr Leu 
65                  70                  75                  80  


Tyr Glu His Asn Phe Ala Phe Phe Pro Gly Phe Pro Leu Ala Leu Leu 
                85                  90                  95      


Val Gly Thr Glu Leu Leu Arg Pro Leu Arg Gly Leu Leu Ser Leu Arg 
            100                 105                 110         


Ser Cys Leu Leu Ile Ser Val Ala Ser Leu Asn Phe Leu Phe Phe Met 
        115                 120                 125             


Leu Ala Ala Val Ala Leu His Asp Leu Gly Cys Leu Val Leu His Cys 
    130                 135                 140                 


Pro His Gln Ser Phe Tyr Ala Ala Leu Leu Phe Cys Leu Ser Pro Ala 
145                 150                 155                 160 


Asn Val Phe Leu Ala Ala Gly Tyr Ser Glu Ala Leu Phe Ala Leu Leu 
                165                 170                 175     


Thr Phe Ser Ala Met Gly Gln Leu Glu Arg Gly Arg Val Trp Thr Ser 
            180                 185                 190         


Val Leu Leu Phe Ala Phe Ala Thr Gly Val Arg Ser Asn Gly Leu Val 
        195                 200                 205             


Ser Val Gly Phe Leu Met His Ser Gln Cys Gln Gly Phe Phe Ser Ser 
    210                 215                 220                 


Leu Thr Met Leu Asn Pro Leu Arg Gln Leu Phe Lys Leu Met Ala Ser 
225                 230                 235                 240 


Leu Phe Leu Ser Val Phe Thr Leu Gly Leu Pro Phe Ala Leu Phe Gln 
                245                 250                 255     


Tyr Tyr Ala Tyr Thr Gln Phe Cys Leu Pro Gly Ser Ala Arg Pro Ile 
            260                 265                 270         


Pro Glu Pro Leu Val Gln Leu Ala Val Asp Lys Gly Tyr Arg Ile Ala 
        275                 280                 285             


Glu Gly Asn Glu Pro Pro Trp Cys Phe Trp Asp Val Pro Leu Ile Tyr 
    290                 295                 300                 


Ser Tyr Ile Gln Asp Val Tyr Trp Asn Val Gly Phe Leu Lys Tyr Tyr 
305                 310                 315                 320 


Glu Leu Lys Gln Val Pro Asn Phe Leu Leu Ala Ala Pro Val Ala Ile 
                325                 330                 335     


Leu Val Ala Trp Ala Thr Trp Thr Tyr Val Thr Thr His Pro Trp Leu 
            340                 345                 350         


Cys Leu Thr Leu Gly Leu Gln Arg Ser Lys Asn Asn Lys Thr Leu Glu 
        355                 360                 365             


Lys Pro Asp Leu Gly Phe Leu Ser Pro Gln Val Phe Val Tyr Val Val 
    370                 375                 380                 


His Ala Ala Val Leu Leu Leu Phe Gly Gly Leu Cys Met His Val Gln 
385                 390                 395                 400 


Val Leu Thr Arg Phe Leu Gly Ser Ser Thr Pro Ile Met Tyr Trp Phe 
                405                 410                 415     


Pro Ala His Leu Leu Gln Asp Gln Glu Pro Leu Leu Arg Ser Leu Lys 
            420                 425                 430         


Thr Val Pro Trp Lys Pro Leu Ala Glu Asp Ser Pro Pro Gly Gln Lys 
        435                 440                 445             


Val Pro Arg Asn Pro Ile Met Gly Leu Leu Tyr His Trp Lys Thr Cys 
    450                 455                 460                 


Ser Pro Val Thr Arg Tyr Ile Leu Gly Tyr Phe Leu Thr Tyr Trp Leu 
465                 470                 475                 480 


Leu Gly Leu Leu Leu His Cys Asn Phe Leu Pro Trp Thr 
                485                 490             


<210>  4354
<211>  544
<212>  PRT
<213>  Homo sapiens

<400>  4354

Met Ser Arg Cys Ala Gln Ala Ala Glu Val Ala Ala Thr Val Pro Gly 
1               5                   10                  15      


Ala Gly Val Gly Asn Val Gly Leu Arg Pro Pro Met Val Pro Arg Gln 
            20                  25                  30          


Ala Ser Phe Phe Pro Pro Pro Val Pro Asn Pro Phe Val Gln Gln Thr 
        35                  40                  45              


Gln Ile Gly Ser Ala Arg Arg Val Gln Ile Val Leu Leu Gly Ile Ile 
    50                  55                  60                  


Leu Leu Pro Ile Arg Val Leu Leu Val Ala Leu Ile Leu Leu Leu Ala 
65                  70                  75                  80  


Trp Pro Phe Ala Ala Ile Ser Thr Val Cys Cys Pro Glu Lys Leu Thr 
                85                  90                  95      


His Pro Ile Thr Gly Trp Arg Arg Lys Ile Thr Gln Thr Ala Leu Lys 
            100                 105                 110         


Phe Leu Gly Arg Ala Met Phe Phe Ser Met Gly Phe Ile Val Ala Val 
        115                 120                 125             


Lys Gly Lys Ile Ala Ser Pro Leu Glu Ala Pro Val Phe Val Ala Ala 
    130                 135                 140                 


Pro His Ser Thr Phe Phe Asp Gly Ile Ala Cys Val Val Ala Gly Leu 
145                 150                 155                 160 


Pro Ser Met Val Ser Arg Asn Glu Asn Ala Gln Val Pro Leu Ile Gly 
                165                 170                 175     


Arg Leu Leu Arg Ala Val Gln Pro Val Leu Val Ser Arg Val Asp Pro 
            180                 185                 190         


Asp Ser Arg Lys Asn Thr Ile Asn Glu Ile Ile Lys Arg Thr Thr Ser 
        195                 200                 205             


Gly Gly Glu Trp Pro Gln Ile Leu Val Phe Pro Glu Gly Thr Cys Thr 
    210                 215                 220                 


Asn Arg Ser Cys Leu Ile Thr Phe Lys Pro Gly Ala Phe Ile Pro Gly 
225                 230                 235                 240 


Val Pro Val Gln Pro Val Leu Leu Arg Tyr Pro Asn Lys Leu Asp Thr 
                245                 250                 255     


Val Thr Trp Thr Trp Gln Gly Tyr Thr Phe Ile Gln Leu Cys Met Leu 
            260                 265                 270         


Thr Phe Cys Gln Leu Phe Thr Lys Val Glu Val Glu Phe Met Pro Val 
        275                 280                 285             


Gln Val Pro Asn Asp Glu Glu Lys Asn Asp Pro Val Leu Phe Ala Asn 
    290                 295                 300                 


Lys Val Arg Asn Leu Met Ala Glu Ala Leu Gly Ile Pro Val Thr Asp 
305                 310                 315                 320 


His Thr Tyr Glu Asp Cys Arg Leu Met Ile Ser Ala Gly Gln Leu Thr 
                325                 330                 335     


Leu Pro Met Glu Ala Gly Leu Val Glu Phe Thr Lys Ile Ser Arg Lys 
            340                 345                 350         


Leu Lys Leu Asp Trp Asp Gly Val Arg Lys His Leu Asp Glu Tyr Ala 
        355                 360                 365             


Ser Ile Ala Ser Ser Ser Lys Gly Gly Arg Ile Gly Ile Glu Glu Phe 
    370                 375                 380                 


Ala Lys Tyr Leu Lys Leu Pro Val Ser Asp Val Leu Arg Gln Leu Phe 
385                 390                 395                 400 


Ala Leu Phe Asp Arg Asn His Asp Gly Ser Ile Asp Phe Arg Glu Tyr 
                405                 410                 415     


Val Ile Gly Leu Ala Val Leu Cys Asn Pro Ser Asn Thr Glu Glu Ile 
            420                 425                 430         


Ile Gln Val Ala Phe Lys Leu Phe Asp Val Asp Glu Asp Gly Tyr Ile 
        435                 440                 445             


Thr Glu Glu Glu Phe Ser Thr Ile Leu Gln Ala Ser Leu Gly Val Pro 
    450                 455                 460                 


Asp Leu Asp Val Ser Gly Leu Phe Lys Glu Ile Ala Gln Gly Asp Ser 
465                 470                 475                 480 


Ile Ser Tyr Glu Glu Phe Lys Ser Phe Ala Leu Lys His Pro Glu Tyr 
                485                 490                 495     


Ala Lys Ile Phe Thr Thr Tyr Leu Asp Leu Gln Thr Cys His Val Phe 
            500                 505                 510         


Ser Leu Pro Lys Glu Val Gln Thr Thr Pro Ser Thr Ala Ser Asn Lys 
        515                 520                 525             


Val Ser Pro Glu Lys His Glu Glu Ser Thr Ser Asp Lys Lys Asp Asp 
    530                 535                 540                 


<210>  4355
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  4355

Met Gly Arg Thr Tyr Ile Val Glu Glu Thr Val Gly Gln Tyr Leu Ser 
1               5                   10                  15      


Asn Ile Asn Leu Gln Gly Lys Ala Phe Val Ser Gly Leu Leu Ile Gly 
            20                  25                  30          


Gln Cys Ser Ser Gln Lys Asp Tyr Val Ile Leu Ala Thr Arg Thr Pro 
        35                  40                  45              


Pro Lys Glu Glu Gln Ser Glu Asn Leu Lys His Pro Lys Ala Lys Leu 
    50                  55                  60                  


Asp Asn Leu Asp Glu Glu Trp Ala Thr Glu His Ala Cys Gln Val Ser 
65                  70                  75                  80  


Arg Met Leu Pro Gly Gly Leu Leu Val Leu Gly Val Phe Ile Ile Thr 
                85                  90                  95      


Thr Leu Glu Leu Ala Asn Asp Phe Gln Asn Ala Leu Arg Arg Leu Met 
            100                 105                 110         


Phe Ala Val Glu Lys Ser Ile Asn Arg Lys Arg Leu Trp Asn Phe Thr 
        115                 120                 125             


Glu Glu Glu Val Ser Glu Arg Val Thr Leu His Ile Cys Ala Ser Thr 
    130                 135                 140                 


Lys Lys Ile Phe Cys Arg Thr Tyr Asp Ile His Asp Pro Lys Ser Ser 
145                 150                 155                 160 


Ala Arg Pro Ala Asp Trp Lys Tyr Gln Ser Gly Leu Ser Ser Ser Trp 
                165                 170                 175     


Leu Ser Leu Glu Cys Thr Val His Ile Asn Ile His Ile Pro Leu Ser 
            180                 185                 190         


Ala Thr Ser Val Ser Tyr Thr Leu Glu Lys Asn Thr Lys Asn Gly Leu 
        195                 200                 205             


Thr Arg Trp Ala Lys Glu Ile Glu Asn Gly Val Tyr Leu Ile Asn Gly 
    210                 215                 220                 


Gln Val Lys Asp Glu Asp Cys Asp Leu Leu Glu Gly Gln Lys Lys Ser 
225                 230                 235                 240 


Ser Arg Gly Asn Thr Gln Ala Thr Ser His Ser Phe Asp Val Arg Val 
                245                 250                 255     


Leu Thr Gln Leu Leu Leu Asn Ser Asp His Arg Ser Thr Ala Thr Val 
            260                 265                 270         


Gln Ile Cys Ser Gly Ser Val Asn Leu Lys Gly Ala Val Lys Cys Arg 
        275                 280                 285             


Ala Tyr Ile His Ser Ser Lys Pro Lys Val Lys Asp Ala Val Gln Ala 
    290                 295                 300                 


Val Lys Arg Asp Ile Leu Asn Thr Val Ala Asp Arg Cys Glu Met Leu 
305                 310                 315                 320 


Phe Glu Asp Leu Leu Leu Asn Glu Ile Pro Glu Lys Lys Asp Ser Glu 
                325                 330                 335     


Lys Glu Phe His Val Leu Pro Tyr Arg Val Phe Val Pro Leu Pro Gly 
            340                 345                 350         


Ser Thr Val Met Leu Cys Asp Tyr Lys Phe Asp Asp Glu Ser Ala Glu 
        355                 360                 365             


Glu Ile Arg Asp His Phe Met Glu Met Leu Asp His Thr Ile Gln Ile 
    370                 375                 380                 


Glu Asp Leu Glu Ile Ala Glu Glu Thr Asn Thr Ala Cys Met Ser Ser 
385                 390                 395                 400 


Ser Met Asn Ser Gln Ala Ser Leu Asp Asn Thr Asp Asp Glu Gln Pro 
                405                 410                 415     


Lys Gln Pro Ile Lys Thr Thr Met Leu Leu Lys Ile Gln Gln Asn Ile 
            420                 425                 430         


Gly Val Ile Ala Ala Phe Thr Val Ala Val Leu Ala Ala Gly Ile Ser 
        435                 440                 445             


Phe His Tyr Phe Ser Asp 
    450                 


<210>  4356
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  4356

Met Tyr Ala Pro Gly Gly Ala Gly Leu Pro Gly Gly Arg Arg Arg Arg 
1               5                   10                  15      


Ser Pro Gly Gly Ser Ala Leu Pro Lys Gln Pro Glu Arg Ser Leu Ala 
            20                  25                  30          


Ser Ala Leu Pro Gly Ala Leu Ser Ile Thr Ala Leu Cys Thr Ala Leu 
        35                  40                  45              


Ala Glu Pro Ala Trp Leu His Ile His Gly Gly Thr Cys Ser Arg Gln 
    50                  55                  60                  


Glu Leu Gly Val Ser Asp Val Leu Gly Tyr Val His Pro Asp Leu Leu 
65                  70                  75                  80  


Lys Asp Phe Cys Met Asn Pro Gln Thr Val Leu Leu Leu Arg Val Ile 
                85                  90                  95      


Ala Ala Phe Cys Phe Leu Gly Ile Leu Cys Ser Leu Ser Ala Phe Leu 
            100                 105                 110         


Leu Asp Val Phe Gly Pro Lys His Pro Ala Leu Lys Ile Thr Arg Arg 
        115                 120                 125             


Tyr Ala Phe Ala His Ile Leu Thr Val Leu Gln Cys Ala Thr Val Ile 
    130                 135                 140                 


Gly Phe Ser Tyr Trp Ala Ser Glu Leu Ile Leu Ala Gln Gln Gln Gln 
145                 150                 155                 160 


His Lys Lys Tyr His Gly Ser Gln Val Tyr Val Thr Phe Ala Val Ser 
                165                 170                 175     


Phe Tyr Leu Val Ala Gly Ala Gly Gly Ala Ser Ile Leu Ala Thr Ala 
            180                 185                 190         


Ala Asn Leu Leu Arg His Tyr Pro Thr Glu Glu Glu Glu Gln Ala Leu 
        195                 200                 205             


Glu Leu Leu Ser Glu Met Glu Glu Asn Glu Pro Tyr Pro Ala Glu Tyr 
    210                 215                 220                 


Glu Val Ile Asn Gln Phe Gln Pro Pro Pro Ala Tyr Thr Pro 
225                 230                 235             


<210>  4357
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  4357

Pro Leu Tyr Met Glu Arg Ala Ser Glu Pro Ala Arg Pro Ile Ser Phe 
1               5                   10                  15      


Arg Met His Met Ser Ala Pro Ile Glu Asn Ser 
            20                  25          


<210>  4358
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  4358

Met Gly Gly Gly Trp Trp Trp Ala Arg Ala Ala Arg Leu Ala Arg Leu 
1               5                   10                  15      


Arg Phe Arg Arg Ser Leu Leu Pro Pro Gln Arg Pro Arg Ser Gly Gly 
            20                  25                  30          


Ala Arg Gly Ser Phe Ala Pro Gly His Gly Pro Arg Ala Gly Ala Ser 
        35                  40                  45              


Pro Pro Pro Val Ser Glu Leu Asp Arg Ala Asp Ala Trp Leu Leu Arg 
    50                  55                  60                  


Lys Ala His Glu Thr Ala Phe Leu Ser Trp Phe Arg Asn Gly Leu Leu 
65                  70                  75                  80  


Ala Ser Gly Ile Gly Val Ile Ser Phe Met Gln Ser Asp Met Gly Arg 
                85                  90                  95      


Glu Ala Ala Tyr Gly Phe Phe Leu Leu Gly Gly Leu Cys Val Val Trp 
            100                 105                 110         


Gly Ser Ala Ser Tyr Ala Val Gly Leu Ala Ala Leu Arg Gly Pro Met 
        115                 120                 125             


Gln Leu Thr Leu Gly Gly Ala Ala Val Gly Ala Gly Ala Val Leu Ala 
    130                 135                 140                 


Ala Ser Leu Leu Trp Ala Cys Ala Val Gly Leu Tyr Met Gly Gln Leu 
145                 150                 155                 160 


Glu Leu Asp Val Glu Leu Val Pro Glu Asp Asp Gly Thr Ala Ser Ala 
                165                 170                 175     


Glu Gly Pro Asp Glu Ala Gly Arg Pro Pro Pro Glu 
            180                 185             


<210>  4359
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  4359

Met Ala Ala Arg Val Ala Ala Val Arg Ala Ala Ala Trp Leu Leu Leu 
1               5                   10                  15      


Gly Ala Ala Thr Gly Leu Thr Arg Gly Pro Ala Ala Ala Phe Thr Ala 
            20                  25                  30          


Ala Arg Ser Asp Ala Gly Ile Arg Ala Met Cys Ser Glu Ile Ile Leu 
        35                  40                  45              


Arg Gln Glu Val Leu Lys Asp Gly Phe His Arg Asp Leu Leu Ile Lys 
    50                  55                  60                  


Val Lys Phe Gly Glu Ser Ile Glu Asp Leu His Thr Cys Arg Leu Leu 
65                  70                  75                  80  


Ile Lys Gln Asp Ile Pro Ala Gly Leu Tyr Val Asp Pro Tyr Glu Leu 
                85                  90                  95      


Ala Ser Leu Arg Glu Arg Asn Ile Thr Glu Ala Val Met Val Ser Glu 
            100                 105                 110         


Asn Phe Asp Ile Glu Ala Pro Asn Tyr Leu Ser Lys Glu Ser Glu Val 
        115                 120                 125             


Leu Ile Tyr Ala Arg Arg Asp Ser Gln Cys Ile Asp Cys Phe Gln Ala 
    130                 135                 140                 


Phe Leu Pro Val His Cys Arg Tyr His Arg Pro His Ser Glu Asp Gly 
145                 150                 155                 160 


Glu Ala Ser Ile Val Val Asn Asn Pro Asp Leu Leu Met Phe Cys Asp 
                165                 170                 175     


Gln Glu Phe Pro Ile Leu Lys Cys Trp Ala His Ser Glu Val Ala Ala 
            180                 185                 190         


Pro Cys Ala Leu Glu Asn Glu Asp Ile Cys Gln Trp Asn Lys Met Lys 
        195                 200                 205             


Tyr Lys Ser Val Tyr Lys Asn Val Ile Leu Gln Val Pro Val Gly Leu 
    210                 215                 220                 


Thr Val His Thr Ser Leu Val Cys Ser Val Thr Leu Leu Ile Thr Ile 
225                 230                 235                 240 


Leu Cys Ser Thr Leu Ile Leu Val Ala Val Phe Lys Tyr Gly His Phe 
                245                 250                 255     


Ser Leu 
        


<210>  4360
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  4360

Met Leu Phe Leu Ala Leu Gly Ser Pro Trp Ala Val Glu Leu Pro Leu 
1               5                   10                  15      


Cys Gly Arg Arg Thr Ala Leu Cys Ala Ala Ala Ala Leu Arg Gly Pro 
            20                  25                  30          


Arg Ala Ser Val Ser Arg Ala Ser Ser Ser Ser Gly Pro Ser Gly Pro 
        35                  40                  45              


Val Ala Gly Trp Ser Thr Gly Pro Ser Gly Ala Ala Arg Leu Leu Arg 
    50                  55                  60                  


Arg Pro Gly Arg Ala Gln Ile Pro Val Tyr Trp Glu Gly Tyr Val Arg 
65                  70                  75                  80  


Phe Leu Asn Thr Pro Ser Asp Lys Ser Glu Asp Gly Arg Leu Ile Tyr 
                85                  90                  95      


Thr Gly Asn Met Ala Arg Ala Val Phe Gly Val Lys Cys Phe Ser Tyr 
            100                 105                 110         


Ser Thr Ser Leu Ile Gly Leu Thr Phe Leu Pro Tyr Ile Phe Thr Gln 
        115                 120                 125             


Asn Asn Ala Ile Ser Glu Ser Val Pro Leu Pro Ile Gln Ile Ile Phe 
    130                 135                 140                 


Tyr Gly Ile Met Gly Ser Phe Thr Val Ile Thr Pro Val Leu Leu His 
145                 150                 155                 160 


Phe Ile Thr Lys Gly Tyr Val Ile Arg Leu Tyr His Glu Ala Thr Thr 
                165                 170                 175     


Asp Thr Tyr Lys Ala Ile Thr Tyr Asn Ala Met Leu Ala Glu Thr Ser 
            180                 185                 190         


Thr Val Phe His Gln Asn Asp Val Lys Ile Pro Asp Ala Lys His Val 
        195                 200                 205             


Phe Thr Thr Phe Tyr Ala Lys Thr Lys Ser Leu Leu Val Asn Pro Val 
    210                 215                 220                 


Leu Phe Pro Asn Arg Glu Asp Tyr Ile His Leu Met Gly Tyr Asp Lys 
225                 230                 235                 240 


Glu Glu Phe Ile Leu Tyr Met Glu Glu Thr Ser Glu Glu Lys Arg His 
                245                 250                 255     


Lys Asp Asp Lys 
            260 


<210>  4361
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  4361

Met Met Ser Glu His Asp Leu Ala Asp Val Val Gln Ile Ala Val Glu 
1               5                   10                  15      


Asp Leu Ser Pro Asp His Pro Val Val Leu Glu Asn His Val Val Thr 
            20                  25                  30          


Asp Glu Asp Glu Pro Ala Leu Lys Arg Gln Arg Leu Glu Ile Asn Cys 
        35                  40                  45              


Gln Asp Pro Ser Ile Lys Ser Phe Leu Tyr Ser Ile Asn Gln Thr Ile 
    50                  55                  60                  


Cys Leu Arg Leu Asp Ser Ile Glu Ala Lys Leu Gln Ala Leu Glu Ala 
65                  70                  75                  80  


Thr Cys Lys Ser Leu Glu Glu Lys Leu Asp Leu Val Thr Asn Lys Gln 
                85                  90                  95      


His Ser Pro Ile Gln Val Pro Met Val Ala Gly Ser Pro Leu Gly Ala 
            100                 105                 110         


Thr Gln Thr Cys Asn Lys Val Arg Cys Ala Val Pro Gly Arg Arg Gln 
        115                 120                 125             


Asn Thr Ile Val Val Lys Val Pro Gly Gln Glu Asp Ser His His Glu 
    130                 135                 140                 


Asp Gly Glu Ser Gly Ser Glu Ala Ser Asp Ser Val Ser Ser Cys Gly 
145                 150                 155                 160 


Gln Ala Gly Ser Gln Ser Ile Gly Ser Asn Val Thr Leu Ile Thr Leu 
                165                 170                 175     


Asn Ser Glu Glu Asp Tyr Pro Asn Gly Thr Trp Leu Gly Asp Glu Asn 
            180                 185                 190         


Asn Pro Glu Met Arg Val Arg Cys Ala Ile Ile Pro Ser Asp Met Leu 
        195                 200                 205             


His Ile Ser Thr Asn Cys Arg Thr Ala Glu Lys Met Ala Leu Thr Leu 
    210                 215                 220                 


Leu Asp Tyr Leu Phe His Arg Glu Val Gln Ala Val Ser Asn Leu Ser 
225                 230                 235                 240 


Gly Gln Gly Lys His Gly Lys Lys Gln Leu Asp Pro Leu Thr Ile Tyr 
                245                 250                 255     


Gly Ile Arg Cys His Leu Phe Tyr Lys Phe Gly Ile Thr Glu Ser Asp 
            260                 265                 270         


Trp Tyr Arg Ile Lys Gln Ser Ile Asp Ser Lys Cys Arg Thr Ala Trp 
        275                 280                 285             


Arg Arg Lys Gln Arg Gly Gln Ser Leu Ala Val Lys Ser Phe Ser Arg 
    290                 295                 300                 


Arg Thr Pro Asn Ser Ser Ser Tyr Cys Pro Ser Glu Pro Met Met Ser 
305                 310                 315                 320 


Thr Pro Pro Pro Ala Ser Glu Leu Pro Gln Pro Gln Pro Gln Pro Gln 
                325                 330                 335     


Ala Leu His Tyr Ala Leu Ala Asn Ala Gln Gln Val Gln Ile His Gln 
            340                 345                 350         


Ile Gly Glu Asp Gly Gln Val Gln Val Ile Pro Gln Gly His Leu His 
        355                 360                 365             


Ile Ala Gln Val Pro Gln Gly Glu Gln Val Gln Ile Thr Gln Asp Ser 
    370                 375                 380                 


Glu Gly Asn Leu Gln Ile His His Val Gly Gln Asp Gly Gln Val Leu 
385                 390                 395                 400 


Gln Gly Ala Gln Leu Ile Ala Val Ala Ser Ser Asp Pro Ala Ala Ala 
                405                 410                 415     


Gly Val Asp Gly Ser Pro Leu Gln Gly Ser Asp Ile Gln Val Gln Tyr 
            420                 425                 430         


Val Gln Leu Ala Pro Val Ser Asp His Thr Ala Gly Ala Gln Thr Ala 
        435                 440                 445             


Glu Ala Leu Gln Pro Thr Leu Gln Pro Glu Met Gln Leu Glu His Gly 
    450                 455                 460                 


Ala Ile Gln Ile Gln 
465                 


<210>  4362
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  4362

Met Ala Trp Thr Lys Tyr Gln Leu Phe Leu Ala Gly Leu Met Leu Val 
1               5                   10                  15      


Thr Gly Ser Ile Asn Thr Leu Ser Ala Lys Trp Ala Asp Asn Phe Met 
            20                  25                  30          


Ala Glu Gly Cys Gly Gly Ser Lys Glu His Ser Phe Gln His Pro Phe 
        35                  40                  45              


Leu Gln Ala Val Gly Met Phe Leu Gly Glu Phe Ser Cys Leu Ala Ala 
    50                  55                  60                  


Phe Tyr Leu Leu Arg Cys Arg Ala Ala Gly Gln Ser Asp Ser Ser Val 
65                  70                  75                  80  


Asp Pro Gln Gln Pro Phe Asn Pro Leu Leu Phe Leu Pro Pro Ala Leu 
                85                  90                  95      


Cys Asp Met Thr Gly Thr Ser Leu Met Tyr Val Ala Leu Asn Met Thr 
            100                 105                 110         


Ser Ala Ser Ser Phe Gln Met Leu Arg Gly Ala Val Ile Ile Phe Thr 
        115                 120                 125             


Gly Leu Phe Ser Val Ala Phe Leu Gly Arg Arg Leu Val Leu Ser Gln 
    130                 135                 140                 


Trp Leu Gly Ile Leu Ala Thr Ile Ala Gly Leu Val Val Val Gly Leu 
145                 150                 155                 160 


Ala Asp Leu Leu Ser Lys His Asp Ser Gln His Lys Leu Ser Glu Val 
                165                 170                 175     


Ile Thr Gly Asp Leu Leu Ile Ile Met Ala Gln Ile Ile Val Ala Ile 
            180                 185                 190         


Gln Met Val Leu Glu Glu Lys Phe Val Tyr Lys His Asn Val His Pro 
        195                 200                 205             


Leu Arg Ala Val Gly Thr Glu Gly Leu Phe Gly Phe Val Ile Leu Ser 
    210                 215                 220                 


Leu Leu Leu Val Pro Met Tyr Tyr Ile Pro Ala Gly Ser Phe Ser Gly 
225                 230                 235                 240 


Asn Pro Arg Gly Thr Leu Glu Asp Ala Leu Asp Ala Phe Cys Gln Val 
                245                 250                 255     


Gly Gln Gln Pro Leu Ile Ala Val Ala Leu Leu Gly Asn Ile Ser Ser 
            260                 265                 270         


Ile Ala Phe Phe Asn Phe Ala Gly Ile Ser Val Thr Lys Glu Leu Ser 
        275                 280                 285             


Ala Thr Thr Arg Met Val Leu Asp Ser Leu Arg Thr Val Val Ile Trp 
    290                 295                 300                 


Ala Leu Ser Leu Ala Leu Gly Trp Glu Ala Phe His Ala Leu Gln Ile 
305                 310                 315                 320 


Leu Gly Phe Leu Ile Leu Leu Ile Gly Thr Ala Leu Tyr Asn Gly Leu 
                325                 330                 335     


His Arg Pro Leu Leu Gly Arg Leu Ser Arg Gly Arg Pro Leu Ala Glu 
            340                 345                 350         


Glu Ser Glu Gln Glu Arg Leu Leu Gly Gly Thr Arg Thr Pro Ile Asn 
        355                 360                 365             


Asp Ala Ser 
    370     


<210>  4363
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  4363

Met Ala Leu Ala Arg Pro Arg Pro Arg Leu Gly Asp Leu Ile Glu Ile 
1               5                   10                  15      


Ser Arg Phe Gly Tyr Ala His Trp Ala Ile Tyr Val Gly Asp Gly Tyr 
            20                  25                  30          


Val Val His Leu Ala Pro Ala Ser Glu Ile Ala Gly Ala Gly Ala Ala 
        35                  40                  45              


Ser Val Leu Ser Ala Leu Thr Asn Lys Ala Ile Val Lys Lys Glu Leu 
    50                  55                  60                  


Leu Ser Val Val Ala Gly Gly Asp Asn Tyr Arg Val Asn Asn Lys His 
65                  70                  75                  80  


Asp Asp Arg Tyr Thr Pro Leu Pro Ser Asn Lys Ile Val Lys Arg Ala 
                85                  90                  95      


Glu Glu Leu Val Gly Gln Glu Leu Pro Tyr Ser Leu Thr Ser Asp Asn 
            100                 105                 110         


Cys Glu His Phe Val Asn His Leu Arg Tyr Gly Val Ser Arg Ser Asp 
        115                 120                 125             


Gln Val Thr Gly Ala Val Thr Thr Val Gly Val Ala Ala Gly Leu Leu 
    130                 135                 140                 


Ala Ala Ala Ser Leu Val Gly Ile Leu Leu Ala Arg Ser Lys Arg Glu 
145                 150                 155                 160 


Arg Gln 
        


<210>  4364
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  4364

Met Ala Leu Arg His Leu Ala Leu Leu Ala Gly Leu Leu Val Gly Val 
1               5                   10                  15      


Ala Ser Lys Ser Met Glu Asn Thr Ala Gln Leu Pro Glu Cys Cys Val 
            20                  25                  30          


Asp Val Val Gly Val Asn Ala Ser Cys Pro Gly Ala Ser Leu Cys Gly 
        35                  40                  45              


Pro Gly Cys Tyr Arg Arg Trp Asn Ala Asp Gly Ser Ala Ser Cys Val 
    50                  55                  60                  


Arg Cys Gly Asn Gly Thr Leu Pro Ala Tyr Asn Gly Ser Glu Cys Arg 
65                  70                  75                  80  


Ser Phe Ala Gly Pro Gly Ala Pro Phe Pro Met Asn Arg Ser Ser Gly 
                85                  90                  95      


Thr Pro Gly Arg Pro His Pro Gly Ala Pro Arg Val Ala Ala Ser Leu 
            100                 105                 110         


Phe Leu Gly Thr Phe Phe Ile Ser Ser Gly Leu Ile Leu Ser Val Ala 
        115                 120                 125             


Gly Phe Phe Tyr Leu Lys Arg Ser Ser Lys Leu Pro Arg Ala Cys Tyr 
    130                 135                 140                 


Arg Arg Asn Lys Ala Pro Ala Leu Gln Pro Gly Glu Ala Ala Ala Met 
145                 150                 155                 160 


Ile Pro Pro Pro Gln Ser Ser Val Arg Lys Pro Arg Tyr Val Arg Arg 
                165                 170                 175     


Glu Arg Pro Leu Asp Arg Ala Thr Asp Pro Ala Ala Phe Pro Gly Glu 
            180                 185                 190         


Ala Arg Ile Ser Asn Val 
        195             


<210>  4365
<211>  843
<212>  PRT
<213>  Homo sapiens

<400>  4365

Met Trp Gly Arg Leu Trp Pro Leu Leu Leu Ser Ile Leu Thr Ala Thr 
1               5                   10                  15      


Ala Val Pro Gly Pro Ser Leu Arg Arg Pro Ser Arg Glu Leu Asp Ala 
            20                  25                  30          


Thr Pro Arg Met Thr Ile Pro Tyr Glu Glu Leu Ser Gly Thr Arg His 
        35                  40                  45              


Phe Lys Gly Gln Ala Gln Asn Tyr Ser Thr Leu Leu Leu Glu Glu Ala 
    50                  55                  60                  


Ser Ala Arg Leu Leu Val Gly Ala Arg Gly Ala Leu Phe Ser Leu Ser 
65                  70                  75                  80  


Ala Asn Asp Ile Gly Asp Gly Ala His Lys Glu Ile His Trp Glu Ala 
                85                  90                  95      


Ser Pro Glu Met Gln Ser Lys Cys His Gln Lys Gly Lys Asn Asn Gln 
            100                 105                 110         


Thr Glu Cys Phe Asn His Val Arg Phe Leu Gln Arg Leu Asn Ser Thr 
        115                 120                 125             


His Leu Tyr Ala Cys Gly Thr His Ala Phe Gln Pro Leu Cys Ala Ala 
    130                 135                 140                 


Ile Asp Ala Glu Ala Phe Thr Leu Pro Thr Ser Phe Glu Glu Gly Lys 
145                 150                 155                 160 


Glu Lys Cys Pro Tyr Asp Pro Ala Arg Gly Phe Thr Gly Leu Ile Ile 
                165                 170                 175     


Asp Gly Gly Leu Tyr Thr Ala Thr Arg Tyr Glu Phe Arg Ser Ile Pro 
            180                 185                 190         


Asp Ile Arg Arg Ser Arg His Pro His Ser Leu Arg Thr Glu Glu Thr 
        195                 200                 205             


Pro Met His Trp Leu Asn Asp Ala Glu Phe Val Phe Ser Val Leu Val 
    210                 215                 220                 


Arg Glu Ser Lys Ala Ser Ala Val Gly Asp Asp Asp Lys Val Tyr Tyr 
225                 230                 235                 240 


Phe Phe Thr Glu Arg Ala Thr Glu Glu Gly Ser Gly Ser Phe Thr Gln 
                245                 250                 255     


Ser Arg Ser Ser His Arg Val Ala Arg Val Ala Arg Val Cys Lys Gly 
            260                 265                 270         


Asp Leu Gly Gly Lys Lys Ile Leu Gln Lys Lys Trp Thr Ser Phe Leu 
        275                 280                 285             


Lys Ala Arg Leu Ile Cys His Ile Pro Leu Tyr Glu Thr Leu Arg Gly 
    290                 295                 300                 


Val Cys Ser Leu Asp Ala Glu Thr Ser Ser Arg Thr His Phe Tyr Ala 
305                 310                 315                 320 


Ala Phe Thr Leu Ser Thr Gln Trp Lys Thr Leu Glu Ala Ser Ala Ile 
                325                 330                 335     


Cys Arg Tyr Asp Leu Ala Glu Ile Gln Ala Val Phe Ala Gly Pro Tyr 
            340                 345                 350         


Met Glu Tyr Gln Asp Gly Ser Arg Arg Trp Gly Arg Tyr Glu Gly Gly 
        355                 360                 365             


Val Pro Glu Pro Arg Pro Gly Ser Cys Ile Thr Asp Ser Leu Arg Ser 
    370                 375                 380                 


Gln Gly Tyr Asn Ser Ser Gln Asp Leu Pro Ser Leu Val Leu Asp Phe 
385                 390                 395                 400 


Val Lys Leu His Pro Leu Met Ala Arg Pro Val Val Pro Thr Arg Gly 
                405                 410                 415     


Arg Pro Leu Leu Leu Lys Arg Asn Ile Arg Tyr Thr His Leu Thr Gly 
            420                 425                 430         


Thr Pro Val Thr Thr Pro Ala Gly Pro Thr Tyr Asp Leu Leu Phe Leu 
        435                 440                 445             


Gly Thr Ala Asp Gly Trp Ile His Lys Ala Val Val Leu Gly Ser Gly 
    450                 455                 460                 


Met His Ile Ile Glu Glu Thr Gln Val Phe Arg Glu Ser Gln Ser Val 
465                 470                 475                 480 


Glu Asn Leu Val Ile Ser Leu Leu Gln His Ser Leu Tyr Val Gly Ala 
                485                 490                 495     


Pro Ser Gly Val Ile Gln Leu Pro Leu Ser Ser Cys Ser Arg Tyr Arg 
            500                 505                 510         


Ser Cys Tyr Asp Cys Ile Leu Ala Arg Asp Pro Tyr Cys Gly Trp Asp 
        515                 520                 525             


Pro Gly Thr His Ala Cys Ala Ala Ala Thr Thr Ile Ala Asn Arg Ser 
    530                 535                 540                 


Gln Gly Ser Arg Thr Ala Leu Ile Gln Asp Ile Glu Arg Gly Asn Arg 
545                 550                 555                 560 


Gly Cys Glu Ser Ser Arg Asp Thr Gly Pro Pro Pro Pro Leu Lys Thr 
                565                 570                 575     


Arg Ser Val Leu Arg Gly Asp Asp Val Leu Leu Pro Cys Asp Gln Pro 
            580                 585                 590         


Ser Asn Leu Ala Arg Ala Leu Trp Leu Leu Asn Gly Ser Met Gly Leu 
        595                 600                 605             


Ser Asp Gly Gln Gly Gly Tyr Arg Val Gly Val Asp Gly Leu Leu Val 
    610                 615                 620                 


Thr Asp Ala Gln Pro Glu His Ser Gly Asn Tyr Gly Cys Tyr Ala Glu 
625                 630                 635                 640 


Glu Asn Gly Leu Arg Thr Leu Leu Ala Ser Tyr Ser Leu Thr Val Arg 
                645                 650                 655     


Pro Ala Thr Pro Ala Pro Ala Pro Lys Ala Pro Ala Thr Pro Gly Ala 
            660                 665                 670         


Gln Leu Ala Pro Asp Val Arg Leu Leu Tyr Val Leu Ala Ile Ala Ala 
        675                 680                 685             


Leu Gly Gly Leu Cys Leu Ile Leu Ala Ser Ser Leu Leu Tyr Val Ala 
    690                 695                 700                 


Cys Leu Arg Glu Gly Arg Arg Gly Arg Arg Arg Lys Tyr Ser Leu Gly 
705                 710                 715                 720 


Arg Ala Ser Arg Ala Gly Gly Ser Ala Val Gln Leu Gln Thr Val Ser 
                725                 730                 735     


Gly Gln Cys Pro Gly Glu Glu Asp Glu Gly Asp Asp Glu Gly Ala Gly 
            740                 745                 750         


Gly Leu Glu Gly Ser Cys Leu Gln Ile Ile Pro Gly Glu Gly Ala Pro 
        755                 760                 765             


Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Glu Leu Thr Asn 
    770                 775                 780                 


Gly Leu Val Ala Leu Pro Ser Arg Leu Arg Arg Met Asn Gly Asn Ser 
785                 790                 795                 800 


Tyr Val Leu Leu Arg Gln Ser Asn Asn Gly Val Pro Ala Gly Pro Cys 
                805                 810                 815     


Ser Phe Ala Glu Glu Leu Ser Arg Ile Leu Glu Lys Arg Lys His Thr 
            820                 825                 830         


Gln Leu Val Glu Gln Leu Asp Glu Ser Ser Val 
        835                 840             


<210>  4366
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  4366

Met Gly Ala Ser Ser Ser Ser Ala Leu Ala Arg Leu Gly Leu Pro Ala 
1               5                   10                  15      


Arg Pro Trp Pro Arg Trp Leu Gly Val Ala Ala Leu Gly Leu Ala Ala 
            20                  25                  30          


Val Ala Leu Gly Thr Val Ala Trp Arg Arg Ala Trp Pro Arg Arg Arg 
        35                  40                  45              


Arg Arg Leu Gln Gln Val Gly Thr Val Ala Lys Leu Trp Ile Tyr Pro 
    50                  55                  60                  


Val Lys Ser Cys Lys Gly Val Pro Val Ser Glu Ala Glu Cys Thr Ala 
65                  70                  75                  80  


Met Gly Leu Arg Ser Gly Asn Leu Arg Asp Arg Phe Trp Leu Val Ile 
                85                  90                  95      


Lys Glu Asp Gly His Met Val Thr Ala Arg Gln Glu Pro Arg Leu Val 
            100                 105                 110         


Leu Ile Ser Ile Ile Tyr Glu Asn Asn Cys Leu Ile Phe Arg Ala Pro 
        115                 120                 125             


Asp Met Asp Gln Leu Val Leu Pro Ser Lys Gln Pro Ser Ser Asn Lys 
    130                 135                 140                 


Leu His Asn Cys Arg Ile Phe Gly Leu Asp Ile Lys Gly Arg Asp Cys 
145                 150                 155                 160 


Gly Asn Glu Ala Ala Lys Trp Phe Thr Asn Phe Leu Lys Thr Glu Ala 
                165                 170                 175     


Tyr Arg Leu Val Gln Phe Glu Thr Asn Met Lys Gly Arg Thr Ser Arg 
            180                 185                 190         


Lys Leu Leu Pro Thr Leu Asp Gln Asn Phe Gln Val Ala Tyr Pro Asp 
        195                 200                 205             


Tyr Cys Pro Leu Leu Ile Met Thr Asp Ala Ser Leu Val Asp Leu Asn 
    210                 215                 220                 


Thr Arg Met Glu Lys Lys Met Lys Met Glu Asn Phe Arg Pro Asn Ile 
225                 230                 235                 240 


Val Val Thr Gly Cys Asp Ala Phe Glu Glu Asp Thr Trp Asp Glu Leu 
                245                 250                 255     


Leu Ile Gly Ser Val Glu Val Lys Lys Val Met Ala Cys Pro Arg Cys 
            260                 265                 270         


Ile Leu Thr Thr Val Asp Pro Asp Thr Gly Val Ile Asp Arg Lys Gln 
        275                 280                 285             


Pro Leu Asp Thr Leu Lys Ser Tyr Arg Leu Cys Asp Pro Ser Glu Arg 
    290                 295                 300                 


Glu Leu Tyr Lys Leu Ser Pro Leu Phe Gly Ile Tyr Tyr Ser Val Glu 
305                 310                 315                 320 


Lys Ile Gly Ser Leu Arg Val Gly Asp Pro Val Tyr Arg Met Val 
                325                 330                 335 


<210>  4367
<211>  816
<212>  PRT
<213>  Homo sapiens

<400>  4367

Met Ala Val Ser Leu Asp Asp Asp Val Pro Leu Ile Leu Thr Leu Asp 
1               5                   10                  15      


Glu Gly Gly Ser Ala Pro Leu Ala Pro Ser Asn Gly Leu Gly Gln Glu 
            20                  25                  30          


Glu Leu Pro Ser Lys Asn Gly Gly Ser Tyr Ala Ile His Asp Ser Gln 
        35                  40                  45              


Ala Pro Ser Leu Ser Ser Gly Gly Glu Ser Ser Pro Ser Ser Pro Ala 
    50                  55                  60                  


His Asn Trp Glu Met Asn Tyr Gln Glu Ala Ala Ile Tyr Leu Gln Glu 
65                  70                  75                  80  


Gly Glu Asn Asn Asp Lys Phe Phe Thr His Pro Lys Asp Ala Lys Ala 
                85                  90                  95      


Leu Ala Ala Tyr Leu Phe Ala His Asn His Leu Phe Tyr Leu Met Glu 
            100                 105                 110         


Leu Ala Thr Ala Leu Leu Leu Leu Leu Leu Ser Leu Cys Glu Ala Pro 
        115                 120                 125             


Ala Val Pro Ala Leu Arg Leu Gly Ile Tyr Val His Ala Thr Leu Glu 
    130                 135                 140                 


Leu Phe Ala Leu Met Val Val Val Phe Glu Leu Cys Met Lys Leu Arg 
145                 150                 155                 160 


Trp Leu Gly Leu His Thr Phe Ile Arg His Lys Arg Thr Met Val Lys 
                165                 170                 175     


Thr Ser Val Leu Val Val Gln Phe Val Glu Ala Ile Val Val Leu Val 
            180                 185                 190         


Arg Gln Met Ser His Val Arg Val Thr Arg Ala Leu Arg Cys Ile Phe 
        195                 200                 205             


Leu Val Asp Cys Arg Tyr Cys Gly Gly Val Arg Arg Asn Leu Arg Gln 
    210                 215                 220                 


Ile Phe Gln Ser Leu Pro Pro Phe Met Asp Ile Leu Leu Leu Leu Leu 
225                 230                 235                 240 


Phe Phe Met Ile Ile Phe Ala Ile Leu Gly Phe Tyr Leu Phe Ser Pro 
                245                 250                 255     


Asn Pro Ser Asp Pro Tyr Phe Ser Thr Leu Glu Asn Ser Ile Val Ser 
            260                 265                 270         


Leu Phe Val Leu Leu Thr Thr Ala Asn Phe Pro Asp Val Met Met Pro 
        275                 280                 285             


Ser Tyr Ser Arg Asn Pro Trp Ser Cys Val Phe Phe Ile Val Tyr Leu 
    290                 295                 300                 


Ser Ile Glu Leu Tyr Phe Ile Met Asn Leu Leu Leu Ala Val Val Phe 
305                 310                 315                 320 


Asp Thr Phe Asn Asp Ile Glu Lys Arg Lys Phe Lys Ser Leu Leu Leu 
                325                 330                 335     


His Lys Arg Thr Ala Ile Gln His Ala Tyr Arg Leu Leu Ile Ser Gln 
            340                 345                 350         


Arg Arg Pro Ala Gly Ile Ser Tyr Arg Gln Phe Glu Gly Leu Met Arg 
        355                 360                 365             


Phe Tyr Lys Pro Arg Met Ser Ala Arg Glu Arg Tyr Leu Thr Phe Lys 
    370                 375                 380                 


Ala Leu Asn Gln Asn Asn Thr Pro Leu Leu Ser Leu Lys Asp Phe Tyr 
385                 390                 395                 400 


Asp Ile Tyr Glu Val Ala Ala Leu Lys Trp Lys Ala Lys Lys Asn Arg 
                405                 410                 415     


Glu His Trp Phe Asp Glu Leu Pro Arg Thr Ala Leu Leu Ile Phe Lys 
            420                 425                 430         


Gly Ile Asn Ile Leu Val Lys Ser Lys Ala Phe Gln Tyr Phe Met Tyr 
        435                 440                 445             


Leu Val Val Ala Val Asn Gly Val Trp Ile Leu Val Glu Thr Phe Met 
    450                 455                 460                 


Leu Lys Gly Gly Asn Phe Phe Ser Lys His Val Pro Trp Ser Tyr Leu 
465                 470                 475                 480 


Val Phe Leu Thr Ile Tyr Gly Val Glu Leu Phe Leu Lys Val Ala Gly 
                485                 490                 495     


Leu Gly Pro Val Glu Tyr Leu Ser Ser Gly Trp Asn Leu Phe Asp Phe 
            500                 505                 510         


Ser Val Thr Val Phe Ala Phe Leu Gly Leu Leu Ala Leu Ala Leu Asn 
        515                 520                 525             


Met Glu Pro Phe Tyr Phe Ile Val Val Leu Arg Pro Leu Gln Leu Leu 
    530                 535                 540                 


Arg Leu Phe Lys Leu Lys Glu Arg Tyr Arg Asn Val Leu Asp Thr Met 
545                 550                 555                 560 


Phe Glu Leu Leu Pro Arg Met Ala Ser Leu Gly Leu Thr Leu Leu Ile 
                565                 570                 575     


Phe Tyr Tyr Ser Phe Ala Ile Val Gly Met Glu Phe Phe Cys Gly Ile 
            580                 585                 590         


Val Phe Pro Asn Cys Cys Asn Thr Ser Thr Val Ala Asp Ala Tyr Arg 
        595                 600                 605             


Trp Arg Asn His Thr Val Gly Asn Arg Thr Val Val Glu Glu Gly Tyr 
    610                 615                 620                 


Tyr Tyr Leu Asn Asn Phe Asp Asn Ile Leu Asn Ser Phe Val Thr Leu 
625                 630                 635                 640 


Phe Glu Leu Thr Val Val Asn Asn Trp Tyr Ile Ile Met Glu Gly Val 
                645                 650                 655     


Thr Ser Gln Thr Ser His Trp Ser Arg Leu Tyr Phe Met Thr Phe Tyr 
            660                 665                 670         


Ile Val Thr Met Val Val Met Thr Ile Ile Val Ala Phe Ile Leu Glu 
        675                 680                 685             


Ala Phe Val Phe Arg Met Asn Tyr Ser Arg Lys Asn Gln Asp Ser Glu 
    690                 695                 700                 


Val Asp Gly Gly Ile Thr Leu Glu Lys Glu Ile Ser Lys Glu Glu Leu 
705                 710                 715                 720 


Val Ala Val Leu Glu Leu Tyr Arg Glu Ala Arg Gly Ala Ser Ser Asp 
                725                 730                 735     


Val Thr Arg Leu Leu Glu Thr Leu Ser Gln Met Glu Arg Tyr Gln Gln 
            740                 745                 750         


His Ser Met Val Phe Leu Gly Arg Arg Ser Arg Thr Lys Ser Asp Leu 
        755                 760                 765             


Ser Leu Lys Met Tyr Gln Glu Glu Ile Gln Glu Trp Tyr Glu Glu His 
    770                 775                 780                 


Ala Arg Glu Gln Glu Gln Gln Arg Gln Leu Ser Ser Ser Ala Ala Pro 
785                 790                 795                 800 


Ala Ala Gln Gln Pro Pro Gly Ser Arg Gln Arg Ser Gln Thr Val Thr 
                805                 810                 815     


<210>  4368
<211>  677
<212>  PRT
<213>  Homo sapiens

<400>  4368

Met Lys Val Leu Gly Arg Ser Phe Phe Trp Val Leu Phe Pro Val Leu 
1               5                   10                  15      


Pro Trp Ala Val Gln Ala Val Glu His Glu Glu Val Ala Gln Arg Val 
            20                  25                  30          


Ile Lys Leu His Arg Gly Arg Gly Val Ala Ala Met Gln Ser Arg Gln 
        35                  40                  45              


Trp Val Arg Asp Ser Cys Arg Lys Leu Ser Gly Leu Leu Arg Gln Lys 
    50                  55                  60                  


Asn Ala Val Leu Asn Lys Leu Lys Thr Ala Ile Gly Ala Val Glu Lys 
65                  70                  75                  80  


Asp Val Gly Leu Ser Asp Glu Glu Lys Leu Phe Gln Val His Thr Phe 
                85                  90                  95      


Glu Ile Phe Gln Lys Glu Leu Asn Glu Ser Glu Asn Ser Val Phe Gln 
            100                 105                 110         


Ala Val Tyr Gly Leu Gln Arg Ala Leu Gln Gly Asp Tyr Lys Asp Val 
        115                 120                 125             


Val Asn Met Lys Glu Ser Ser Arg Gln Arg Leu Glu Ala Leu Arg Glu 
    130                 135                 140                 


Ala Ala Ile Lys Glu Glu Thr Glu Tyr Met Glu Leu Leu Ala Ala Glu 
145                 150                 155                 160 


Lys His Gln Val Glu Ala Leu Lys Asn Met Gln His Gln Asn Gln Ser 
                165                 170                 175     


Leu Ser Met Leu Asp Glu Ile Leu Glu Asp Val Arg Lys Ala Ala Asp 
            180                 185                 190         


Arg Leu Glu Glu Glu Ile Glu Glu His Ala Phe Asp Asp Asn Lys Ser 
        195                 200                 205             


Val Lys Gly Val Asn Phe Glu Ala Val Leu Arg Val Glu Glu Glu Glu 
    210                 215                 220                 


Ala Asn Ser Lys Gln Asn Ile Thr Lys Arg Glu Val Glu Asp Asp Leu 
225                 230                 235                 240 


Gly Leu Ser Met Leu Ile Asp Ser Gln Asn Asn Gln Tyr Ile Leu Thr 
                245                 250                 255     


Lys Pro Arg Asp Ser Thr Ile Pro Arg Ala Asp His His Phe Ile Lys 
            260                 265                 270         


Asp Ile Val Thr Ile Gly Met Leu Ser Leu Pro Cys Gly Trp Leu Cys 
        275                 280                 285             


Thr Ala Ile Gly Leu Pro Thr Met Phe Gly Tyr Ile Ile Cys Gly Val 
    290                 295                 300                 


Leu Leu Gly Pro Ser Gly Leu Asn Ser Ile Lys Ser Ile Val Gln Val 
305                 310                 315                 320 


Glu Thr Leu Gly Glu Phe Gly Val Phe Phe Thr Leu Phe Leu Val Gly 
                325                 330                 335     


Leu Glu Phe Ser Pro Glu Lys Leu Arg Lys Val Trp Lys Ile Ser Leu 
            340                 345                 350         


Gln Gly Pro Cys Tyr Met Thr Leu Leu Met Ile Ala Phe Gly Leu Leu 
        355                 360                 365             


Trp Gly His Leu Leu Arg Ile Lys Pro Thr Gln Ser Val Phe Ile Ser 
    370                 375                 380                 


Thr Cys Leu Ser Leu Ser Ser Thr Pro Leu Val Ser Arg Phe Leu Met 
385                 390                 395                 400 


Gly Ser Ala Arg Gly Asp Lys Glu Gly Asp Ile Asp Tyr Ser Thr Val 
                405                 410                 415     


Leu Leu Gly Met Leu Val Thr Gln Asp Val Gln Leu Gly Leu Phe Met 
            420                 425                 430         


Ala Val Met Pro Thr Leu Ile Gln Ala Gly Ala Ser Ala Ser Ser Ser 
        435                 440                 445             


Ile Val Val Glu Val Leu Arg Ile Leu Val Leu Ile Gly Gln Ile Leu 
    450                 455                 460                 


Phe Ser Leu Ala Ala Val Phe Leu Leu Cys Leu Val Ile Lys Lys Tyr 
465                 470                 475                 480 


Leu Ile Gly Pro Tyr Tyr Arg Lys Leu His Met Glu Ser Lys Gly Asn 
                485                 490                 495     


Lys Glu Ile Leu Ile Leu Gly Ile Ser Ala Phe Ile Phe Leu Met Leu 
            500                 505                 510         


Thr Val Thr Glu Leu Leu Asp Val Ser Met Glu Leu Gly Cys Phe Leu 
        515                 520                 525             


Ala Gly Ala Leu Val Ser Ser Gln Gly Pro Val Val Thr Glu Glu Ile 
    530                 535                 540                 


Ala Thr Ser Ile Glu Pro Ile Arg Asp Phe Leu Ala Ile Val Phe Phe 
545                 550                 555                 560 


Ala Ser Ile Gly Leu His Val Phe Pro Thr Phe Val Ala Tyr Glu Leu 
                565                 570                 575     


Thr Val Leu Val Phe Leu Thr Leu Ser Val Val Val Met Lys Phe Leu 
            580                 585                 590         


Leu Ala Ala Leu Val Leu Ser Leu Ile Leu Pro Arg Ser Ser Gln Tyr 
        595                 600                 605             


Ile Lys Trp Ile Val Ser Ala Gly Leu Ala Gln Val Ser Glu Phe Ser 
    610                 615                 620                 


Phe Val Leu Gly Ser Arg Ala Arg Arg Ala Gly Val Ile Ser Arg Glu 
625                 630                 635                 640 


Val Tyr Leu Leu Ile Leu Ser Val Thr Thr Leu Ser Leu Leu Leu Ala 
                645                 650                 655     


Pro Val Leu Trp Arg Ala Ala Ile Thr Arg Cys Val Pro Arg Pro Glu 
            660                 665                 670         


Arg Arg Ser Ser Leu 
        675         


<210>  4369
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  4369

Met Gly Pro Arg Val Leu Gln Pro Pro Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Leu Leu Leu Ala Ala Leu Pro Cys Gly Ala Glu Glu Ala Ser Pro Leu 
            20                  25                  30          


Arg Pro Ala Gln Val Thr Leu Ser Pro Pro Pro Ala Val Thr Asn Gly 
        35                  40                  45              


Ser Gln Pro Gly Ala Pro His Asn Ser Thr His Thr Arg Pro Pro Gly 
    50                  55                  60                  


Ala Ser Gly Ser Ala Leu Thr Arg Ser Phe Tyr Val Ile Leu Gly Phe 
65                  70                  75                  80  


Cys Gly Leu Thr Ala Leu Tyr Phe Leu Ile Arg Ala Phe Arg Leu Lys 
                85                  90                  95      


Lys Pro Gln Arg Arg Arg Tyr Gly Leu Leu Ala Asn Thr Glu Asp Pro 
            100                 105                 110         


Thr Glu Met Ala Ser Leu Asp Ser Asp Glu Glu Thr Val Phe Glu Ser 
        115                 120                 125             


Arg Asn Leu Arg 
    130         


<210>  4370
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  4370

Met Leu Gln Arg Gly Leu Trp Pro Trp Arg Thr Arg Leu Leu Pro Thr 
1               5                   10                  15      


Pro Gly Thr Trp Arg Pro Ala Arg Pro Trp Pro Leu Pro Pro Pro Pro 
            20                  25                  30          


Gln Val Leu Arg Val Lys Leu Cys Gly Asn Val Lys Tyr Tyr Gln Ser 
        35                  40                  45              


His His Tyr Ser Thr Val Val Pro Pro Asp Glu Ile Thr Val Ile Tyr 
    50                  55                  60                  


Arg His Gly Leu Pro Leu Val Thr Leu Thr Leu Pro Ser Arg Lys Glu 
65                  70                  75                  80  


Arg Cys Gln Phe Val Val Lys Pro Met Leu Ser Thr Val Gly Ser Phe 
                85                  90                  95      


Leu Gln Asp Leu Gln Asn Glu Asp Lys Gly Ile Lys Thr Ala Ala Ile 
            100                 105                 110         


Phe Thr Ala Asp Gly Asn Met Ile Ser Ala Ser Thr Leu Met Asp Ile 
        115                 120                 125             


Leu Leu Met Asn Asp Phe Lys Leu Val Ile Asn Lys Ile Ala Tyr Asp 
    130                 135                 140                 


Val Gln Cys Pro Lys Arg Glu Lys Pro Ser Asn Glu His Thr Ala Glu 
145                 150                 155                 160 


Met Glu His Met Lys Ser Leu Val His Arg Leu Phe Thr Ile Leu His 
                165                 170                 175     


Leu Glu Glu Ser Gln Lys Lys Arg Glu His His Leu Leu Glu Lys Ile 
            180                 185                 190         


Asp His Leu Lys Glu Gln Leu Gln Pro Leu Glu Gln Val Lys Ala Gly 
        195                 200                 205             


Ile Glu Ala His Ser Glu Ala Lys Thr Ser Gly Leu Leu Trp Ala Gly 
    210                 215                 220                 


Leu Ala Leu Leu Ser Ile Gln Gly Gly Ala Leu Ala Trp Leu Thr Trp 
225                 230                 235                 240 


Trp Val Tyr Ser Trp Asp Ile Met Glu Pro Val Thr Tyr Phe Ile Thr 
                245                 250                 255     


Phe Ala Asn Ser Met Val Phe Phe Ala Tyr Phe Ile Val Thr Arg Gln 
            260                 265                 270         


Asp Tyr Thr Tyr Ser Ala Val Lys Ser Arg Gln Phe Leu Gln Phe Phe 
        275                 280                 285             


His Lys Lys Ser Lys Gln Gln His Phe Asp Val Gln Gln Tyr Asn Lys 
    290                 295                 300                 


Leu Lys Glu Asp Leu Ala Lys Ala Lys Glu Ser Leu Lys Gln Ala Arg 
305                 310                 315                 320 


His Ser Leu Cys Leu Gln Met Gln Val Glu Glu Leu Asn Glu Lys Asn 
                325                 330                 335     


<210>  4371
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  4371

Met Ser Glu Asp Glu Glu Lys Val Lys Leu Arg Arg Leu Glu Pro Ala 
1               5                   10                  15      


Ile Gln Lys Phe Ile Lys Ile Val Ile Pro Thr Asp Leu Glu Arg Leu 
            20                  25                  30          


Arg Lys His Gln Ile Asn Ile Glu Lys Tyr Gln Arg Cys Arg Ile Trp 
        35                  40                  45              


Asp Lys Leu His Glu Glu His Ile Asn Ala Gly Arg Thr Val Gln Gln 
    50                  55                  60                  


Leu Arg Ser Asn Ile Arg Glu Ile Glu Lys Leu Cys Leu Lys Val Arg 
65                  70                  75                  80  


Lys Asp Asp Leu Val Leu Leu Lys Arg Met Ile Asp Pro Val Lys Glu 
                85                  90                  95      


Glu Ala Ser Ala Ala Thr Ala Glu Phe Leu Gln Leu His Leu Glu Ser 
            100                 105                 110         


Val Glu Glu Leu Lys Lys Gln Phe Asn Asp Glu Glu Thr Leu Leu Gln 
        115                 120                 125             


Pro Pro Leu Thr Arg Ser Met Thr Val Gly Gly Ala Phe His Thr Thr 
    130                 135                 140                 


Glu Ala Glu Ala Ser Ser Gln Ser Leu Thr Gln Ile Tyr Ala Leu Pro 
145                 150                 155                 160 


Glu Ile Pro Gln Asp Gln Asn Ala Ala Glu Ser Trp Glu Thr Leu Glu 
                165                 170                 175     


Ala Asp Leu Ile Glu Leu Ser Gln Leu Val Thr Asp Phe Ser Leu Leu 
            180                 185                 190         


Val Asn Ser Gln Gln Glu Lys Ile Asp Ser Ile Ala Asp His Val Asn 
        195                 200                 205             


Ser Ala Ala Val Asn Val Glu Glu Gly Thr Lys Asn Leu Gly Lys Ala 
    210                 215                 220                 


Ala Lys Tyr Lys Leu Ala Ala Leu Pro Val Ala Gly Ala Leu Ile Gly 
225                 230                 235                 240 


Gly Met Val Gly Gly Pro Ile Gly Leu Leu Ala Gly Phe Lys Val Ala 
                245                 250                 255     


Gly Ile Ala Ala Ala Leu Gly Gly Gly Val Leu Gly Phe Thr Gly Gly 
            260                 265                 270         


Lys Leu Ile Gln Arg Lys Lys Gln Lys Met Met Glu Lys Leu Thr Ser 
        275                 280                 285             


Ser Cys Pro Asp Leu Pro Ser Gln Thr Asp Lys Lys Cys Ser 
    290                 295                 300         


<210>  4372
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  4372

Met Asp Glu Leu Val His Asp Leu Ala Ser Ala Leu Glu Gln Thr Ser 
1               5                   10                  15      


Glu Gln Asn Lys Leu Gly Glu Leu Trp Glu Glu Met Ala Leu Ser Pro 
            20                  25                  30          


Arg Gln Gln Arg Arg Gln Leu Arg Lys Arg Arg Gly Arg Lys Arg Arg 
        35                  40                  45              


Ser Asp Phe Thr His Leu Ala Glu His Thr Cys Cys Tyr Ser Glu Ala 
    50                  55                  60                  


Ser Glu Ser Ser Leu Asp Glu Ala Thr Lys Asp Cys Arg Glu Val Ala 
65                  70                  75                  80  


Pro Val Thr Asn Phe Ser Asp Ser Asp Asp Thr Met Val Ala Lys Arg 
                85                  90                  95      


His Pro Ala Leu Asn Ala Ile Val Lys Ser Lys Gln His Ser Trp His 
            100                 105                 110         


Glu Ser Asp Ser Phe Thr Glu Asn Ala Pro Cys Arg Pro Leu Arg Arg 
        115                 120                 125             


Arg Arg Lys Val Lys Arg Val Thr Ser Glu Val Ala Ala Ser Leu Gln 
    130                 135                 140                 


Gln Lys Leu Lys Val Ser Asp Trp Ser Tyr Glu Arg Gly Cys Arg Phe 
145                 150                 155                 160 


Lys Ser Ala Lys Lys Gln Arg Leu Ser Arg Trp Lys Glu Asn Thr Pro 
                165                 170                 175     


Trp Thr Ser Ser Gly His Gly Leu Cys Glu Ser Ala Glu Asn Arg Thr 
            180                 185                 190         


Phe Leu Ser Lys Thr Gly Arg Lys Glu Arg Met Glu Cys Glu Thr Asp 
        195                 200                 205             


Glu Gln Lys Gln Gly Ser Asp Glu Asn Met Ser Glu Cys Glu Thr Ser 
    210                 215                 220                 


Ser Val Cys Ser Ser Ser Asp Thr Gly Leu Phe Thr Asn Asp Glu Gly 
225                 230                 235                 240 


Arg Gln Gly Asp Asp Glu Gln Ser Asp Trp Phe Tyr Glu Gly Glu Cys 
                245                 250                 255     


Val Pro Gly Phe Thr Val Pro Asn Leu Leu Pro Lys Trp Ala Pro Asp 
            260                 265                 270         


His Cys Ser Glu Val Glu Arg Met Asp Ser Gly Leu Asp Lys Phe Ser 
        275                 280                 285             


Asp Ser Thr Phe Leu Leu Pro Ser Arg Pro Ala Gln Arg Gly Tyr His 
    290                 295                 300                 


Thr Arg Leu Asn Arg Leu Pro Gly Ala Ala Ala Arg Cys Leu Arg Lys 
305                 310                 315                 320 


Gly Arg Arg Arg Leu Val Gly Lys Glu Thr Ser Ile Asn Thr Leu Gly 
                325                 330                 335     


Thr Glu Arg Ile Ser His Ile Ile Ser Asp Pro Arg Gln Lys Glu Lys 
            340                 345                 350         


Asn Lys Ala Leu Ala Ser Asp Phe Pro His Ile Ser Ala Cys Ala His 
        355                 360                 365             


Glu Phe Asn Pro Leu Ser Pro Leu Tyr Ser Leu Asp Val Leu Ala Asp 
    370                 375                 380                 


Ala Ser His Arg Arg Cys Ser Pro Ala His Cys Ser Ala Arg Gln Ala 
385                 390                 395                 400 


Asn Val His Trp Gly Pro Pro Cys Ser Arg Asp Ile Lys Arg Lys Arg 
                405                 410                 415     


Lys Pro Val Ala Thr Ala Ser Leu Ser Ser Pro Ser Ala Val His Met 
            420                 425                 430         


Asp Ala Val Glu Pro Thr Thr Pro Ala Ser Gln Ala Pro Lys Ser Pro 
        435                 440                 445             


Ser Ser Glu Trp Leu Val Arg Thr Ser Ala Ala Glu Lys Ala Thr Asp 
    450                 455                 460                 


Ala Thr Thr Ala Thr Phe Phe Lys Met Pro Gln Glu Lys Ser Pro Gly 
465                 470                 475                 480 


Tyr Ser 
        


<210>  4373
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  4373

Met His Gln Ser Leu Thr Gln Gln Arg Ser Ser Asp Met Ser Leu Pro 
1               5                   10                  15      


Asp Ser Met Gly Ala Phe Asn Arg Arg Lys Arg Asn Ser Ile Tyr Val 
            20                  25                  30          


Thr Val Thr Leu Leu Ile Val Ser Val Leu Ile Leu Thr Val Gly Leu 
        35                  40                  45              


Ala Ala Thr Thr Arg Thr Gln Asn Val Thr Val Gly Gly Tyr Tyr Pro 
    50                  55                  60                  


Gly Val Ile Leu Gly Phe Gly Ser Phe Leu Gly Ile Ile Gly Ser Asn 
65                  70                  75                  80  


Leu Ile Glu Asn Lys Arg Gln Met Leu Val Ala Ser Ile Val Phe Ile 
                85                  90                  95      


Ser Phe Gly Val Ile Ala Ala Phe Cys Cys Ala Ile Val Asp Gly Val 
            100                 105                 110         


Phe Ala Ala Arg His Ile Asp Leu Lys Pro Leu Tyr Ala Asn Arg Cys 
        115                 120                 125             


His Tyr Val Pro Lys Thr Ser Gln Lys Glu Ala Glu Glu Val Ile Ser 
    130                 135                 140                 


Ser Ser Thr Lys Asn Ser Pro Ser Thr Arg Val Met Arg Asn Leu Thr 
145                 150                 155                 160 


Gln Ala Ala Arg Glu Val Asn Cys Pro His Leu Ser Arg Glu Phe Cys 
                165                 170                 175     


Thr Pro Arg Ile Arg Gly Asn Thr Cys Phe Cys Cys Asp Leu Tyr Asn 
            180                 185                 190         


Cys Gly Asn Arg Val Glu Ile Thr Gly Gly Tyr Tyr Glu Tyr Ile Asp 
        195                 200                 205             


Val Ser Ser Cys Gln Asp Ile Ile His Leu Tyr His Leu Leu Trp Ser 
    210                 215                 220                 


Ala Thr Ile Leu Asn Ile Val Gly Leu Phe Leu Gly Ile Ile Thr Ala 
225                 230                 235                 240 


Ala Val Leu Gly Gly Phe Lys Asp Met Asn Pro Thr Leu Pro Ala Leu 
                245                 250                 255     


Asn Cys Ser Val Glu Asn Thr His Pro Thr Val Ser Tyr Tyr Ala His 
            260                 265                 270         


Pro Gln Val Ala Ser Tyr Asn Thr Tyr Tyr His Ser Pro Pro His Leu 
        275                 280                 285             


Pro Pro Tyr Ser Ala Tyr Asp Phe Gln His Ser Gly Val Phe Pro Ser 
    290                 295                 300                 


Ser Pro Pro Ser Gly Leu Ser Asp Glu Pro Gln Ser Ala Ser Pro Ser 
305                 310                 315                 320 


Pro Ser Tyr Met Trp Ser Ser Ser Ala Pro Pro Arg Tyr Ser Pro Pro 
                325                 330                 335     


Tyr Tyr Pro Pro Phe Glu Lys Pro Pro Pro Tyr Ser Pro 
            340                 345                 


<210>  4374
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  4374

Met Glu Lys Gln Cys Cys Ser His Pro Val Ile Cys Ser Leu Ser Thr 
1               5                   10                  15      


Met Tyr Thr Phe Leu Leu Gly Ala Ile Phe Ile Ala Leu Ser Ser Ser 
            20                  25                  30          


Arg Ile Leu Leu Val Lys Tyr Ser Ala Asn Glu Glu Asn Lys Tyr Asp 
        35                  40                  45              


Tyr Leu Pro Thr Thr Val Asn Val Cys Ser Glu Leu Val Lys Leu Val 
    50                  55                  60                  


Phe Cys Val Leu Val Ser Phe Cys Val Ile Lys Lys Asp His Gln Ser 
65                  70                  75                  80  


Arg Asn Leu Lys Tyr Ala Ser Trp Lys Glu Phe Ser Asp Phe Met Lys 
                85                  90                  95      


Trp Ser Ile Pro Ala Phe Leu Tyr Phe Leu Asp Asn Leu Ile Val Phe 
            100                 105                 110         


Tyr Val Leu Ser Tyr Leu Gln Pro Ala Met Ala Val Ile Phe Ser Asn 
        115                 120                 125             


Phe Ser Ile Ile Thr Thr Ala Leu Leu Phe Arg Ile Val Leu Lys Arg 
    130                 135                 140                 


Arg Leu Asn Trp Ile Gln Trp Ala Ser Leu Leu Thr Leu Phe Leu Ser 
145                 150                 155                 160 


Ile Val Ala Leu Thr Ala Gly Thr Lys Thr Leu Gln His Asn Leu Ala 
                165                 170                 175     


Gly Arg Gly Phe His His Asp Ala Phe Phe Ser Pro Ser Asn Ser Cys 
            180                 185                 190         


Leu Leu Phe Arg Ser Glu Cys Pro Arg Lys Asp Asn Cys Thr Ala Lys 
        195                 200                 205             


Glu Trp Thr Phe Pro Glu Ala Lys Trp Asn Thr Thr Ala Arg Val Phe 
    210                 215                 220                 


Ser His Ile Arg Leu Gly Met Gly His Val Leu Ile Ile Val Gln Cys 
225                 230                 235                 240 


Phe Ile Ser Ser Met Ala Asn Ile Tyr Asn Glu Lys Ile Leu Lys Glu 
                245                 250                 255     


Gly Asn Gln Leu Thr Glu Ser Ile Phe Ile Gln Asn Ser Lys Leu Tyr 
            260                 265                 270         


Phe Phe Gly Ile Leu Phe Asn Gly Leu Thr Leu Gly Leu Gln Arg Ser 
        275                 280                 285             


Asn Arg Asp Gln Ile Lys Asn Cys Gly Phe Phe Tyr Gly His Ser Ala 
    290                 295                 300                 


Phe Ser Val Ala Leu Ile Phe Val Thr Ala Phe Gln Gly Leu Ser Val 
305                 310                 315                 320 


Ala Phe Ile Leu Lys Phe Leu Asp Asn Met Phe His Val Leu Met Ala 
                325                 330                 335     


Gln Val Thr Thr Val Ile Ile Thr Thr Val Ser Val Leu Val Phe Asp 
            340                 345                 350         


Phe Arg Pro Ser Leu Glu Phe Phe Leu Glu Ala Pro Ser Val Leu Leu 
        355                 360                 365             


Ser Ile Phe Ile Tyr Asn Ala Ser Lys Pro Gln Val Pro Glu Tyr Ala 
    370                 375                 380                 


Pro Arg Gln Glu Arg Ile Arg Asp Leu Ser Gly Asn Leu Trp Glu Arg 
385                 390                 395                 400 


Ser Ser Gly Asp Gly Glu Glu Leu Glu Arg Leu Thr Lys Pro Lys Ser 
                405                 410                 415     


Asp Glu Ser Asp Glu Asp Thr Phe 
            420                 


<210>  4375
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  4375

Met Gly Thr Ile His Leu Phe Arg Lys Pro Gln Arg Ser Phe Phe Gly 
1               5                   10                  15      


Lys Leu Leu Arg Glu Phe Arg Leu Val Ala Ala Asp Arg Arg Ser Trp 
            20                  25                  30          


Lys Ile Leu Leu Phe Gly Val Ile Asn Leu Ile Cys Thr Gly Phe Leu 
        35                  40                  45              


Leu Met Trp Cys Ser Ser Thr Asn Ser Ile Ala Leu Thr Ala Tyr Thr 
    50                  55                  60                  


Tyr Leu Thr Ile Phe Asp Leu Phe Ser Leu Met Thr Cys Leu Ile Ser 
65                  70                  75                  80  


Tyr Trp Val Thr Leu Arg Lys Pro Ser Pro Val Tyr Ser Phe Gly Phe 
                85                  90                  95      


Glu Arg Leu Glu Val Leu Ala Val Phe Ala Ser Thr Val Leu Ala Gln 
            100                 105                 110         


Leu Gly Ala Leu Phe Ile Leu Lys Glu Ser Ala Glu Arg Phe Leu Glu 
        115                 120                 125             


Gln Pro Glu Ile His Thr Gly Arg Leu Leu Val Gly Thr Phe Val Ala 
    130                 135                 140                 


Leu Cys Phe Asn Leu Phe Thr Met Leu Ser Ile Arg Asn Lys Pro Phe 
145                 150                 155                 160 


Ala Tyr Val Ser Glu Ala Ala Ser Thr Ser Trp Leu Gln Glu His Val 
                165                 170                 175     


Ala Asp Leu Ser Arg Ser Leu Cys Gly Ile Ile Pro Gly Leu Ser Ser 
            180                 185                 190         


Ile Phe Leu Pro Arg Met Asn Pro Phe Val Leu Ile Asp Leu Ala Gly 
        195                 200                 205             


Ala Phe Ala Leu Cys Ile Thr Tyr Met Leu Ile Glu Ile Asn Asn Tyr 
    210                 215                 220                 


Phe Ala Val Asp Thr Ala Ser Ala Ile Ala Ile Ala Leu Met Thr Phe 
225                 230                 235                 240 


Gly Thr Met Tyr Pro Met Ser Val Tyr Ser Gly Lys Val Leu Leu Gln 
                245                 250                 255     


Thr Thr Pro Pro His Val Ile Gly Gln Leu Asp Lys Leu Ile Arg Glu 
            260                 265                 270         


Val Ser Thr Leu Asp Gly Val Leu Glu Val Arg Asn Glu His Phe Trp 
        275                 280                 285             


Thr Leu Gly Phe Gly Ser Leu Ala Gly Ser Val His Val Arg Ile Arg 
    290                 295                 300                 


Arg Asp Ala Asn Glu Gln Met Val Leu Ala His Val Thr Asn Arg Leu 
305                 310                 315                 320 


Tyr Thr Leu Val Ser Thr Leu Thr Val Gln Ile Phe Lys Asp Asp Trp 
                325                 330                 335     


Ile Arg Pro Ala Leu Leu Ser Gly Pro Val Ala Ala Asn Val Leu Asn 
            340                 345                 350         


Phe Ser Asp His His Val Ile Pro Met Pro Leu Leu Lys Gly Thr Asp 
        355                 360                 365             


Asp Leu Asn Pro Val Thr Ser Thr Pro Ala Lys Pro Ser Ser Pro Pro 
    370                 375                 380                 


Pro Glu Phe Ser Phe Asn Thr Pro Gly Lys Asn Val Asn Pro Val Ile 
385                 390                 395                 400 


Leu Leu Asn Thr Gln Thr Arg Pro Tyr Gly Phe Gly Leu Asn His Gly 
                405                 410                 415     


His Thr Pro Tyr Ser Ser Met Leu Asn Gln Gly Leu Gly Val Pro Gly 
            420                 425                 430         


Ile Gly Ala Thr Gln Gly Leu Arg Thr Gly Phe Thr Asn Ile Pro Ser 
        435                 440                 445             


Arg Tyr Gly Thr Asn Asn Arg Ile Gly Gln Pro Arg Pro 
    450                 455                 460     


<210>  4376
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  4376

Met Asp Glu Leu Val His Asp Leu Ala Ser Ala Leu Glu Gln Thr Ser 
1               5                   10                  15      


Glu Gln Asn Lys Leu Gly Glu Leu Trp Glu Glu Met Ala Leu Ser Pro 
            20                  25                  30          


Arg Gln Gln Arg Arg Gln Leu Arg Lys Arg Arg Gly Arg Lys Arg Arg 
        35                  40                  45              


Ser Asp Phe Thr His Leu Ala Glu His Thr Cys Cys Tyr Ser Glu Ala 
    50                  55                  60                  


Ser Glu Ser Ser Leu Asp Glu Ala Thr Lys Asp Cys Arg Glu Val Ala 
65                  70                  75                  80  


Pro Val Thr Asn Phe Ser Asp Ser Asp Asp Thr Met Val Ala Lys Arg 
                85                  90                  95      


His Pro Ala Leu Asn Ala Ile Val Lys Ser Lys Gln His Ser Trp His 
            100                 105                 110         


Glu Ser Asp Ser Phe Thr Glu Asn Ala Pro Cys Arg Pro Leu Arg Arg 
        115                 120                 125             


Arg Arg Lys Val Lys Arg Val Thr Ser Glu Val Ala Ala Ser Leu Gln 
    130                 135                 140                 


Gln Lys Leu Lys Val Ser Asp Trp Ser Tyr Glu Arg Gly Cys Arg Phe 
145                 150                 155                 160 


Lys Ser Ala Lys Lys Gln Arg Leu Ser Arg Trp Lys Glu Asn Thr Pro 
                165                 170                 175     


Trp Thr Ser Ser Gly His Gly Leu Cys Glu Ser Ala Glu Asn Arg Thr 
            180                 185                 190         


Phe Leu Ser Lys Thr Gly Arg Lys Glu Arg Met Glu Cys Glu Thr Asp 
        195                 200                 205             


Glu Gln Lys Gln Gly Ser Asp Glu Asn Met Ser Glu Cys Glu Thr Ser 
    210                 215                 220                 


Ser Val Cys Ser Ser Ser Asp Thr Gly Leu Phe Thr Asn Asp Glu Gly 
225                 230                 235                 240 


Arg Gln Gly Asp Asp Glu Gln Ser Asp Trp Phe Tyr Glu Gly Glu Cys 
                245                 250                 255     


Val Pro Gly Phe Thr Val Pro Asn Leu Leu Pro Lys Trp Ala Pro Asp 
            260                 265                 270         


His Cys Ser Glu Val Glu Arg Met Asp Ser Gly Leu Asp Lys Phe Ser 
        275                 280                 285             


Asp Ser Thr Phe Leu Leu Pro Ser Arg Pro Ala Gln Arg Gly Tyr His 
    290                 295                 300                 


Thr Arg Leu Asn Arg Leu Pro Gly Ala Ala Ala Arg Cys Leu Arg Lys 
305                 310                 315                 320 


Gly Arg Arg Arg Leu Val Gly Lys Glu Thr Ser Ile Asn Thr Leu Gly 
                325                 330                 335     


Thr Glu Arg Ile Ser His Ile Ile Ser Asp Pro Arg Gln Lys Asp Phe 
            340                 345                 350         


Trp Leu Pro Ser Ala Gly Lys Arg Glu Arg Asn Gln Phe Asn Pro Leu 
        355                 360                 365             


Ser Pro Leu Tyr Ser Leu Asp Val Leu Ala Asp Ala Ser His Arg Arg 
    370                 375                 380                 


Cys Ser Pro Ala His Cys Ser Ala Arg Gln Ala Asn Val His Trp Gly 
385                 390                 395                 400 


Pro Pro Cys Ser Arg Asp Ile Lys Arg Lys Arg Lys Pro Val Ala Thr 
                405                 410                 415     


Ala Ser Leu Ser Ser Pro Ser Ala Val His Met Asp Ala Val Glu Pro 
            420                 425                 430         


Thr Thr Pro Ala Ser Gln Ala Pro Lys Ser Pro Ser Ser Glu Trp Leu 
        435                 440                 445             


Val Arg Thr Ser Ala Ala Glu Lys Ala Thr Asp Ala Thr Thr Ala Thr 
    450                 455                 460                 


Phe Phe Lys Met Pro Gln Glu Lys Ser Pro Gly Tyr Ser 
465                 470                 475         


<210>  4377
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  4377

Met Tyr His Gly Met Asn Pro Ser Asn Gly Asp Gly Phe Leu Glu Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Pro Gln Ser Pro Gln Arg Leu Leu Ala Val 
            20                  25                  30          


Ile Leu Trp Phe Gln Leu Ala Leu Cys Phe Gly Pro Ala Gln Leu Thr 
        35                  40                  45              


Gly Gly Phe Asp Asp Leu Gln Val Cys Ala Asp Pro Gly Ile Pro Glu 
    50                  55                  60                  


Asn Gly Phe Arg Thr Pro Ser Gly Gly Val Phe Phe Glu Gly Ser Val 
65                  70                  75                  80  


Ala Arg Phe His Cys Gln Asp Gly Phe Lys Leu Lys Gly Ala Thr Lys 
                85                  90                  95      


Arg Leu Cys Leu Lys His Phe Asn Gly Thr Leu Gly Trp Ile Pro Ser 
            100                 105                 110         


Asp Asn Ser Ile Cys Val Gln Glu Asp Cys Arg Ile Pro Gln Ile Glu 
        115                 120                 125             


Asp Ala Glu Ile His Asn Lys Thr Tyr Arg His Gly Glu Lys Leu Ile 
    130                 135                 140                 


Ile Thr Cys His Glu Gly Phe Lys Ile Arg Tyr Pro Asp Leu His Asn 
145                 150                 155                 160 


Met Val Ser Leu Cys Arg Asp Asp Gly Thr Trp Asn Asn Leu Pro Ile 
                165                 170                 175     


Cys Gln Gly Cys Leu Arg Pro Leu Ala Ser Ser Asn Gly Tyr Val Asn 
            180                 185                 190         


Ile Ser Glu Leu Gln Thr Ser Phe Pro Val Gly Thr Val Ile Ser Tyr 
        195                 200                 205             


Arg Cys Phe Pro Gly Phe Lys Leu Asp Gly Ser Ala Tyr Leu Glu Cys 
    210                 215                 220                 


Leu Gln Asn Leu Ile Trp Ser Ser Ser Pro Pro Arg Cys Leu Ala Leu 
225                 230                 235                 240 


Glu Val Cys Pro Leu Pro Pro Met Val Ser His Gly Asp Phe Val Cys 
                245                 250                 255     


His Pro Arg Pro Cys Glu Arg Tyr Asn His Gly Thr Val Val Glu Phe 
            260                 265                 270         


Tyr Cys Asp Pro Gly Tyr Ser Leu Thr Ser Asp Tyr Lys Tyr Ile Thr 
        275                 280                 285             


Cys Gln Tyr Gly Glu Trp Phe Pro Ser Tyr Gln Val Tyr Cys Ile Lys 
    290                 295                 300                 


Ser Glu Gln Thr Trp Pro Ser Thr His Glu Thr Leu Leu Thr Thr Trp 
305                 310                 315                 320 


Lys Ile Val Ala Phe Thr Ala Thr Ser Val Leu Leu Val Leu Leu Leu 
                325                 330                 335     


Val Ile Leu Ala Arg Met Phe Gln Thr Lys Phe Lys Ala His Phe Pro 
            340                 345                 350         


Pro Arg Gly Pro Pro Arg Ser Ser Ser Ser Asp Pro Asp Phe Val Val 
        355                 360                 365             


Val Asp Gly Val Pro Val Met Leu Pro Ser Tyr Asp Glu Ala Val Ser 
    370                 375                 380                 


Gly Gly Leu Ser Ala Leu Gly Pro Gly Tyr Met Ala Ser Val Gly Gln 
385                 390                 395                 400 


Gly Cys Pro Leu Pro Val Asp Asp Gln Ser Pro Pro Ala Tyr Pro Gly 
                405                 410                 415     


Ser Gly Asp Thr Asp Thr Gly Pro Gly Glu Ser Glu Thr Cys Asp Ser 
            420                 425                 430         


Val Ser Gly Ser Ser Glu Leu Leu Gln Ser Leu Tyr Ser Pro Pro Arg 
        435                 440                 445             


Cys Gln Glu Ser Thr His Pro Ala Ser Asp Asn Pro Asp Ile Ile Ala 
    450                 455                 460                 


Ser Thr Ala Glu Glu Val Ala Ser Thr Ser Pro Gly Ile Asp Ile Ala 
465                 470                 475                 480 


Asp Glu Ile Pro Leu Met Glu Glu Asp Pro 
                485                 490 


<210>  4378
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  4378

Met Ala Ala Pro Thr Leu Gly Arg Leu Val Leu Thr His Leu Leu Val 
1               5                   10                  15      


Ala Leu Phe Gly Met Gly Ser Trp Ala Ala Val Asn Gly Ile Trp Val 
            20                  25                  30          


Glu Leu Pro Val Val Val Lys Asp Leu Pro Glu Gly Trp Ser Leu Pro 
        35                  40                  45              


Ser Tyr Leu Ser Val Val Val Ala Leu Gly Asn Leu Gly Leu Leu Val 
    50                  55                  60                  


Val Thr Leu Trp Arg Gln Leu Ala Pro Gly Lys Gly Glu Gln Val Pro 
65                  70                  75                  80  


Ile Gln Val Val Gln Val Leu Ser Val Val Gly Thr Ala Leu Leu Ala 
                85                  90                  95      


Pro Leu Trp His His Val Ala Pro Val Ala Gly Gln Leu His Ser Val 
            100                 105                 110         


Ala Phe Leu Thr Leu Ala Leu Val Leu Ala Met Ala Cys Cys Thr Ser 
        115                 120                 125             


Asn Val Thr Phe Leu Pro Phe Leu Ser His Leu Pro Pro Pro Phe Leu 
    130                 135                 140                 


Arg Ser Phe Phe Leu Gly Gln Gly Leu Ser Ala Leu Leu Pro Cys Val 
145                 150                 155                 160 


Leu Ala Leu Val Gln Gly Val Gly Arg Leu Glu Cys Pro Pro Ala Pro 
                165                 170                 175     


Thr Asn Gly Thr Ser Gly Pro Pro Leu Asp Phe Pro Glu Arg Phe Pro 
            180                 185                 190         


Ala Ser Thr Phe Phe Trp Ala Leu Thr Ala Leu Leu Val Thr Ser Ala 
        195                 200                 205             


Ala Ala Phe Arg Gly Leu Leu Leu Leu Leu Pro Ser Leu Pro Ser Val 
    210                 215                 220                 


Thr Thr Gly Gly Ser Gly Pro Glu Leu Gln Leu Gly Ser Pro Gly Ala 
225                 230                 235                 240 


Glu Glu Glu Glu Lys Glu Glu Glu Glu Ala Leu Pro Leu Gln Glu Pro 
                245                 250                 255     


Pro Ser Gln Ala Ala Gly Thr Ile Pro Gly Pro Asp Pro Glu Ala His 
            260                 265                 270         


Gln Leu Phe Ser Ala His Gly Ala Phe Leu Leu Gly Leu Met Ala Phe 
        275                 280                 285             


Thr Ser Ala Val Thr Asn Gly Val Leu Pro Ser Val Gln Ser Phe Ser 
    290                 295                 300                 


Cys Leu Pro Tyr Gly Arg Leu Ala Tyr His Leu Ala Val Val Leu Gly 
305                 310                 315                 320 


Ser Ala Ala Asn Pro Leu Ala Cys Phe Leu Ala Met Gly Val Leu Cys 
                325                 330                 335     


Arg Ser Leu Ala Gly Leu Val Gly Leu Ser Leu Leu Gly Met Leu Phe 
            340                 345                 350         


Gly Ala Tyr Leu Met Ala Leu Ala Ile Leu Ser Pro Cys Pro Pro Leu 
        355                 360                 365             


Val Gly Thr Thr Ala Gly Val Val Leu Val Val Leu Ser Trp Val Leu 
    370                 375                 380                 


Cys Leu Cys Val Phe Ser Tyr Val Lys Val Ala Ala Ser Ser Leu Leu 
385                 390                 395                 400 


His Gly Gly Gly Arg Pro Ala Leu Leu Ala Ala Gly Val Ala Ile Gln 
                405                 410                 415     


Val Gly Ser Leu Leu Gly Ala Gly Ala Met Phe Pro Pro Thr Ser Ile 
            420                 425                 430         


Tyr His Val Phe Gln Ser Arg Lys Asp Cys Val Asp Pro Cys Gly Pro 
        435                 440                 445             


<210>  4379
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  4379

Met Phe Ser Ile Asn Pro Leu Glu Asn Leu Lys Val Tyr Ile Ser Ser 
1               5                   10                  15      


Arg Pro Pro Leu Val Val Phe Met Ile Ser Val Ser Ala Met Ala Ile 
            20                  25                  30          


Ala Phe Leu Thr Leu Gly Tyr Phe Phe Lys Ile Lys Glu Ile Lys Ser 
        35                  40                  45              


Pro Glu Met Ala Glu Asp Trp Asn Thr Phe Leu Leu Arg Phe Asn Asp 
    50                  55                  60                  


Leu Asp Leu Cys Val Ser Glu Asn Glu Thr Leu Lys His Leu Thr Asn 
65                  70                  75                  80  


Asp Thr Thr Thr Pro Glu Ser Thr Met Thr Ser Gly Gln Ala Arg Ala 
                85                  90                  95      


Ser Thr Gln Ser Pro Gln Ala Leu Glu Asp Ser Gly Pro Val Asn Ile 
            100                 105                 110         


Ser Val Ser Ile Thr Leu Thr Leu Asp Pro Leu Lys Pro Phe Gly Gly 
        115                 120                 125             


Tyr Ser Arg Asn Val Thr His Leu Tyr Ser Thr Ile Leu Gly His Gln 
    130                 135                 140                 


Ile Gly Leu Ser Gly Arg Glu Ala His Glu Glu Ile Asn Ile Thr Phe 
145                 150                 155                 160 


Thr Leu Pro Thr Ala Trp Ser Ser Asp Asp Cys Ala Leu His Gly His 
                165                 170                 175     


Cys Glu Gln Val Val Phe Thr Ala Cys Met Thr Leu Thr Ala Ser Pro 
            180                 185                 190         


Gly Val Phe Pro Val Thr Val Gln Pro Pro His Cys Val Pro Asp Thr 
        195                 200                 205             


Tyr Ser Asn Ala Thr Leu Trp Tyr Lys Ile Phe Thr Thr Ala Arg Asp 
    210                 215                 220                 


Ala Asn Thr Lys Tyr Ala Gln Asp Tyr Asn Pro Phe Trp Cys Tyr Lys 
225                 230                 235                 240 


Gly Ala Ile Gly Lys Val Tyr His Ala Leu Asn Pro Lys Leu Thr Val 
                245                 250                 255     


Ile Val Pro Asp Asp Asp Arg Ser Leu Ile Asn Leu His Leu Met His 
            260                 265                 270         


Thr Ser Tyr Phe Leu Phe Val Met Val Ile Thr Met Phe Cys Tyr Ala 
        275                 280                 285             


Val Ile Lys Gly Arg Pro Ser Lys Leu Arg Gln Ser Asn Pro Glu Phe 
    290                 295                 300                 


Cys Pro Glu Lys Val Ala Leu Ala Glu Ala 
305                 310                 


<210>  4380
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  4380

Met Gly Asn Phe Arg Gly His Ala Leu Pro Gly Thr Phe Phe Phe Ile 
1               5                   10                  15      


Ile Gly Leu Trp Trp Cys Thr Lys Ser Ile Leu Lys Tyr Ile Cys Lys 
            20                  25                  30          


Lys Gln Lys Arg Thr Cys Tyr Leu Gly Ser Lys Thr Leu Phe Tyr Arg 
        35                  40                  45              


Leu Glu Ile Leu Glu Gly Ile Thr Ile Val Gly Met Ala Leu Thr Gly 
    50                  55                  60                  


Met Ala Gly Glu Gln Phe Ile Pro Gly Gly Pro His Leu Met Leu Tyr 
65                  70                  75                  80  


Asp Tyr Lys Gln Gly His Trp Asn Gln Leu Leu Gly Trp His His Phe 
                85                  90                  95      


Thr Met Tyr Phe Phe Phe Gly Leu Leu Gly Val Ala Asp Ile Leu Cys 
            100                 105                 110         


Phe Thr Ile Ser Ser Leu Pro Val Ser Leu Thr Lys Leu Met Leu Ser 
        115                 120                 125             


Asn Ala Leu Phe Val Glu Ala Phe Ile Phe Tyr Asn His Thr His Gly 
    130                 135                 140                 


Arg Glu Met Leu Asp Ile Phe Val His Gln Leu Leu Val Leu Val Val 
145                 150                 155                 160 


Phe Leu Thr Gly Leu Val Ala Phe Leu Glu Phe Leu Val Arg Asn Asn 
                165                 170                 175     


Val Leu Leu Glu Leu Leu Arg Ser Ser Leu Ile Leu Leu Gln Gly Ser 
            180                 185                 190         


Trp Phe Phe Gln Ile Gly Phe Val Leu Tyr Pro Pro Ser Gly Gly Pro 
        195                 200                 205             


Ala Trp Asp Leu Met Asp His Glu Asn Ile Leu Phe Leu Thr Ile Cys 
    210                 215                 220                 


Phe Cys Trp His Tyr Ala Val Thr Ile Val Ile Val Gly Met Asn Tyr 
225                 230                 235                 240 


Ala Phe Ile Thr Trp Leu Val Lys Ser Arg Leu Lys Arg Leu Cys Ser 
                245                 250                 255     


Ser Glu Val Gly Leu Leu Lys Asn Ala Glu Arg Glu Gln Glu Ser Glu 
            260                 265                 270         


Glu Glu Met 
        275 


<210>  4381
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  4381

Met Gly Thr Gln Glu Gly Trp Cys Leu Leu Leu Cys Leu Ala Leu Ser 
1               5                   10                  15      


Gly Ala Ala Glu Thr Lys Pro His Pro Ala Glu Gly Gln Trp Arg Ala 
            20                  25                  30          


Val Asp Val Val Leu Asp Cys Phe Leu Ala Lys Asp Gly Ala His Arg 
        35                  40                  45              


Gly Ala Leu Ala Ser Ser Glu Asp Arg Ala Arg Ala Ser Leu Val Leu 
    50                  55                  60                  


Lys Gln Val Pro Val Leu Asp Asp Gly Ser Leu Glu Asp Phe Thr Asp 
65                  70                  75                  80  


Phe Gln Gly Gly Thr Leu Ala Gln Asp Asp Pro Pro Ile Ile Phe Glu 
                85                  90                  95      


Ala Ser Val Asp Leu Val Gln Ile Pro Gln Ala Glu Ala Leu Leu His 
            100                 105                 110         


Ala Asp Cys Ser Gly Lys Glu Val Thr Cys Glu Ile Ser Arg Tyr Phe 
        115                 120                 125             


Leu Gln Met Thr Glu Thr Thr Val Lys Thr Ala Ala Trp Phe Met Ala 
    130                 135                 140                 


Asn Met Gln Val Ser Gly Gly Gly Pro Ser Ile Ser Leu Val Met Lys 
145                 150                 155                 160 


Thr Pro Arg Val Thr Lys Asn Glu Ala Leu Trp His Pro Thr Leu Asn 
                165                 170                 175     


Leu Pro Leu Ser Pro Gln Gly Thr Val Arg Thr Ala Val Glu Phe Gln 
            180                 185                 190         


Val Met Thr Gln Thr Gln Ser Leu Ser Phe Leu Leu Gly Ser Ser Ala 
        195                 200                 205             


Ser Leu Asp Cys Gly Phe Ser Met Ala Pro Gly Leu Asp Leu Ile Ser 
    210                 215                 220                 


Val Glu Trp Arg Leu Gln His Lys Gly Arg Gly Gln Leu Val Tyr Ser 
225                 230                 235                 240 


Trp Thr Ala Gly Gln Gly Gln Ala Val Arg Lys Gly Ala Thr Leu Glu 
                245                 250                 255     


Pro Ala Gln Leu Gly Met Ala Arg Asp Ala Ser Leu Thr Leu Pro Gly 
            260                 265                 270         


Leu Thr Ile Gln Asp Glu Gly Thr Tyr Ile Cys Gln Ile Thr Thr Ser 
        275                 280                 285             


Leu Tyr Arg Ala Gln Gln Ile Ile Gln Leu Asn Ile Gln Ala Ser Pro 
    290                 295                 300                 


Lys Val Arg Leu Ser Leu Ala Asn Glu Ala Leu Leu Pro Thr Leu Ile 
305                 310                 315                 320 


Cys Asp Ile Ala Gly Tyr Tyr Pro Leu Asp Val Val Val Thr Trp Thr 
                325                 330                 335     


Arg Glu Glu Leu Gly Gly Ser Pro Ala Gln Val Ser Gly Ala Ser Phe 
            340                 345                 350         


Ser Ser Leu Arg Gln Ser Val Ala Gly Thr Tyr Ser Ile Ser Ser Ser 
        355                 360                 365             


Leu Thr Ala Glu Pro Gly Ser Ala Gly Ala Thr Tyr Thr Cys Gln Val 
    370                 375                 380                 


Thr His Ile Ser Leu Glu Glu Pro Leu Gly Ala Ser Thr Gln Val Val 
385                 390                 395                 400 


Pro Pro Glu Arg Arg Thr Ala Leu Gly Val Ile Phe Ala Ser Ser Leu 
                405                 410                 415     


Phe Leu Leu Ala Leu Met Phe Leu Gly Leu Gln Arg Arg Gln Ala Pro 
            420                 425                 430         


Thr Gly Leu Gly Leu Leu Gln Ala Glu Arg Trp Glu Thr Thr Ser Cys 
        435                 440                 445             


Ala Asp Thr Gln Ser Ser His Leu His Glu Asp Arg Thr Ala Arg Val 
    450                 455                 460                 


Ser Gln Pro Ser 
465             


<210>  4382
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  4382

Met Met Ala Gln Ser Lys Ala Asn Gly Ser His Tyr Ala Leu Thr Ala 
1               5                   10                  15      


Ile Gly Leu Gly Met Leu Val Leu Gly Val Ile Met Ala Met Trp Asn 
            20                  25                  30          


Leu Val Pro Gly Phe Ser Ala Ala Glu Lys Pro Thr Ala Gln Gly Ser 
        35                  40                  45              


Asn Lys Thr Glu Val Gly Gly Gly Ile Leu Lys Ser Lys Thr Phe Ser 
    50                  55                  60                  


Val Ala Tyr Val Leu Val Gly Ala Gly Val Met Leu Leu Leu Leu Ser 
65                  70                  75                  80  


Ile Cys Leu Ser Ile Arg Asp Lys Arg Lys Gln Arg Gln Gly Glu Asp 
                85                  90                  95      


Leu Ala His Val Gln His Pro Thr Gly Ala Gly Pro His Ala Gln Glu 
            100                 105                 110         


Glu Asp Ser Gln Glu Glu Glu Glu Glu Asp Glu Glu Ala Ala Ser Arg 
        115                 120                 125             


Tyr Tyr Val Pro Ser Tyr Glu Glu Val Met Asn Thr Asn Tyr Ser Glu 
    130                 135                 140                 


Ala Arg Gly Glu Glu Gln Asn Pro Arg Leu Ser Ile Ser Leu Pro Ser 
145                 150                 155                 160 


Tyr Glu Ser Leu Thr Gly Leu Asp Glu Thr Thr Pro Thr Ser Thr Arg 
                165                 170                 175     


Ala Asp Val Glu Ala Ser Pro Gly Asn Pro Pro Asp Arg Gln Asn Ser 
            180                 185                 190         


Lys Leu Ala Lys Arg Leu Lys Pro Leu Lys Val Arg Arg Ile Lys Ser 
        195                 200                 205             


Glu Lys Leu His Leu Lys Asp Phe Arg Ile Asn Leu Pro Asp Lys Asn 
    210                 215                 220                 


Val Pro Pro Pro Ser Ile Glu Pro Leu Thr Pro Pro Pro Gln Tyr Asp 
225                 230                 235                 240 


Glu Val Gln Glu Lys Ala Pro Asp Thr Arg Pro Pro Asp 
                245                 250             


<210>  4383
<211>  986
<212>  PRT
<213>  Homo sapiens

<400>  4383

Met Arg Val Asn Glu Lys Tyr Ser Thr Leu Pro Ala Glu Asp Arg Ser 
1               5                   10                  15      


Val His Ile Ile Asn Ile Cys Ala Ile Glu Asp Ile Gly Tyr Leu Pro 
            20                  25                  30          


Ser Glu Gly Thr Leu Leu Asn Ser Leu Ser Val Asp Pro Asp Ala Glu 
        35                  40                  45              


Cys Lys Tyr Gly Leu Tyr Phe Arg Asp Gly Arg Arg Lys Val Asp Tyr 
    50                  55                  60                  


Ile Leu Val Tyr His His Lys Arg Pro Ser Gly Asn Arg Thr Leu Val 
65                  70                  75                  80  


Arg Arg Val Gln His Ser Asp Thr Pro Ser Gly Ala Arg Ser Val Lys 
                85                  90                  95      


Gln Asp His Pro Leu Pro Gly Lys Gly Ala Ser Leu Asp Ala Gly Ser 
            100                 105                 110         


Gly Glu Pro Pro Met Asp Tyr His Glu Asp Asp Lys Arg Phe Arg Arg 
        115                 120                 125             


Glu Glu Tyr Glu Gly Asn Leu Leu Glu Ala Gly Leu Glu Leu Glu Arg 
    130                 135                 140                 


Asp Glu Asp Thr Lys Ile His Gly Val Gly Phe Val Lys Ile His Ala 
145                 150                 155                 160 


Pro Trp Asn Val Leu Cys Arg Glu Ala Glu Phe Leu Lys Leu Lys Met 
                165                 170                 175     


Pro Thr Lys Lys Met Tyr His Ile Asn Glu Thr Arg Gly Leu Leu Lys 
            180                 185                 190         


Lys Ile Asn Ser Val Leu Gln Lys Ile Thr Asp Pro Ile Gln Pro Lys 
        195                 200                 205             


Val Ala Glu His Arg Pro Gln Thr Met Lys Arg Leu Ser Tyr Pro Phe 
    210                 215                 220                 


Ser Arg Glu Lys Gln His Leu Phe Asp Leu Ser Asp Lys Asp Ser Phe 
225                 230                 235                 240 


Phe Asp Ser Lys Thr Arg Ser Thr Ile Val Tyr Glu Ile Leu Lys Arg 
                245                 250                 255     


Thr Thr Cys Thr Lys Ala Lys Tyr Ser Met Gly Ile Thr Ser Leu Leu 
            260                 265                 270         


Ala Asn Gly Val Tyr Ala Ala Ala Tyr Pro Leu His Asp Gly Asp Tyr 
        275                 280                 285             


Asn Gly Glu Asn Val Glu Phe Asn Asp Arg Lys Leu Leu Tyr Glu Glu 
    290                 295                 300                 


Trp Ala Arg Tyr Gly Val Phe Tyr Lys Tyr Gln Pro Ile Asp Leu Val 
305                 310                 315                 320 


Arg Lys Tyr Phe Gly Glu Lys Ile Gly Leu Tyr Phe Ala Trp Leu Gly 
                325                 330                 335     


Val Tyr Thr Gln Met Leu Ile Pro Ala Ser Ile Val Gly Ile Ile Val 
            340                 345                 350         


Phe Leu Tyr Gly Cys Ala Thr Met Asp Glu Asn Ile Pro Ser Met Glu 
        355                 360                 365             


Met Cys Asp Gln Arg His Asn Ile Thr Met Cys Pro Leu Cys Asp Lys 
    370                 375                 380                 


Thr Cys Ser Tyr Trp Lys Met Ser Ser Ala Cys Ala Thr Ala Arg Ala 
385                 390                 395                 400 


Ser His Leu Phe Asp Asn Pro Ala Thr Val Phe Phe Ser Val Phe Met 
                405                 410                 415     


Ala Leu Trp Ala Ala Thr Phe Met Glu His Trp Lys Arg Lys Gln Met 
            420                 425                 430         


Arg Leu Asn Tyr Arg Trp Asp Leu Thr Gly Phe Glu Glu Glu Glu Glu 
        435                 440                 445             


Ala Val Lys Asp His Pro Arg Ala Glu Tyr Glu Ala Arg Val Leu Glu 
    450                 455                 460                 


Lys Ser Leu Lys Lys Glu Ser Arg Asn Lys Glu Lys Arg Arg His Ile 
465                 470                 475                 480 


Pro Glu Glu Ser Thr Asn Lys Trp Lys Gln Arg Val Lys Thr Ala Met 
                485                 490                 495     


Ala Gly Val Lys Leu Thr Asp Lys Val Lys Leu Thr Trp Arg Asp Arg 
            500                 505                 510         


Phe Pro Ala Tyr Leu Thr Asn Leu Val Ser Ile Ile Phe Met Ile Ala 
        515                 520                 525             


Val Thr Phe Ala Ile Val Leu Gly Val Ile Ile Tyr Arg Ile Ser Met 
    530                 535                 540                 


Ala Ala Ala Leu Ala Met Asn Ser Ser Pro Ser Val Arg Ser Asn Ile 
545                 550                 555                 560 


Arg Val Thr Val Thr Ala Thr Ala Val Ile Ile Asn Leu Val Val Ile 
                565                 570                 575     


Ile Leu Leu Asp Glu Val Tyr Gly Cys Ile Ala Arg Trp Leu Thr Lys 
            580                 585                 590         


Ile Glu Val Pro Lys Thr Glu Lys Ser Phe Glu Glu Arg Leu Ile Phe 
        595                 600                 605             


Lys Ala Phe Leu Leu Lys Phe Val Asn Ser Tyr Thr Pro Ile Phe Tyr 
    610                 615                 620                 


Val Ala Phe Phe Lys Gly Arg Phe Val Gly Arg Pro Gly Asp Tyr Val 
625                 630                 635                 640 


Tyr Ile Phe Arg Ser Phe Arg Met Glu Glu Cys Ala Pro Gly Gly Cys 
                645                 650                 655     


Leu Met Glu Leu Cys Ile Gln Leu Ser Ile Ile Met Leu Gly Lys Gln 
            660                 665                 670         


Leu Ile Gln Asn Asn Leu Phe Glu Ile Gly Ile Pro Lys Met Lys Lys 
        675                 680                 685             


Leu Ile Arg Tyr Leu Lys Leu Lys Gln Gln Ser Pro Pro Asp His Glu 
    690                 695                 700                 


Glu Cys Val Lys Arg Lys Gln Arg Tyr Glu Val Asp Tyr Asn Leu Glu 
705                 710                 715                 720 


Pro Phe Ala Gly Leu Thr Pro Glu Tyr Met Glu Met Ile Ile Gln Phe 
                725                 730                 735     


Gly Phe Val Thr Leu Phe Val Ala Ser Phe Pro Leu Ala Pro Leu Phe 
            740                 745                 750         


Ala Leu Leu Asn Asn Ile Ile Glu Ile Arg Leu Asp Ala Lys Lys Phe 
        755                 760                 765             


Val Thr Glu Leu Arg Arg Pro Val Ala Val Arg Ala Lys Asp Ile Gly 
    770                 775                 780                 


Ile Trp Tyr Asn Ile Leu Arg Gly Ile Gly Lys Leu Ala Val Ile Ile 
785                 790                 795                 800 


Asn Ala Phe Val Ile Ser Phe Thr Ser Asp Phe Ile Pro Arg Leu Val 
                805                 810                 815     


Tyr Leu Tyr Met Tyr Ser Lys Asn Gly Thr Met His Gly Phe Val Asn 
            820                 825                 830         


His Thr Leu Ser Ser Phe Asn Val Ser Asp Phe Gln Asn Gly Thr Ala 
        835                 840                 845             


Pro Asn Asp Pro Leu Asp Leu Gly Tyr Glu Val Gln Ile Cys Arg Tyr 
    850                 855                 860                 


Lys Asp Tyr Arg Glu Pro Pro Trp Ser Glu Asn Lys Tyr Asp Ile Ser 
865                 870                 875                 880 


Lys Asp Phe Trp Ala Val Leu Ala Ala Arg Leu Ala Phe Val Ile Val 
                885                 890                 895     


Phe Gln Asn Leu Val Met Phe Met Ser Asp Phe Val Asp Trp Val Ile 
            900                 905                 910         


Pro Asp Ile Pro Lys Asp Ile Ser Gln Gln Ile His Lys Glu Lys Val 
        915                 920                 925             


Leu Met Val Glu Leu Phe Met Arg Glu Glu Gln Asp Lys Gln Gln Leu 
    930                 935                 940                 


Leu Glu Thr Trp Met Glu Lys Glu Arg Gln Lys Asp Glu Pro Pro Cys 
945                 950                 955                 960 


Asn His His Asn Thr Lys Ala Cys Pro Asp Ser Leu Gly Ser Pro Ala 
                965                 970                 975     


Pro Ser His Ala Tyr His Gly Gly Val Leu 
            980                 985     


<210>  4384
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  4384

Met Phe Phe Gly Gly Glu Gly Ser Leu Thr Tyr Thr Leu Val Ile Ile 
1               5                   10                  15      


Cys Phe Leu Thr Leu Arg Leu Ser Ala Ser Gln Asn Cys Leu Lys Lys 
            20                  25                  30          


Ser Leu Glu Asp Val Val Ile Asp Ile Gln Ser Ser Leu Ser Lys Gly 
        35                  40                  45              


Ile Arg Gly Asn Glu Pro Val Tyr Thr Ser Thr Gln Glu Asp Cys Ile 
    50                  55                  60                  


Asn Ser Cys Cys Ser Thr Lys Asn Ile Ser Gly Asp Lys Ala Cys Asn 
65                  70                  75                  80  


Leu Met Ile Phe Asp Thr Arg Lys Thr Ala Arg Gln Pro Asn Cys Tyr 
                85                  90                  95      


Leu Phe Phe Cys Pro Asn Glu Glu Ala Cys Pro Leu Lys Pro Ala Lys 
            100                 105                 110         


Gly Leu Met Ser Tyr Arg Ile Ile Thr Asp Phe Pro Ser Leu Thr Arg 
        115                 120                 125             


Asn Leu Pro Ser Gln Glu Leu Pro Gln Glu Asp Ser Leu Leu His Gly 
    130                 135                 140                 


Gln Phe Ser Gln Ala Val Thr Pro Leu Ala His His His Thr Asp Tyr 
145                 150                 155                 160 


Ser Lys Pro Thr Asp Ile Ser Trp Arg Asp Thr Leu Ser Gln Lys Phe 
                165                 170                 175     


Gly Ser Ser Asp His Leu Glu Lys Leu Phe Lys Met Asp Glu Ala Ser 
            180                 185                 190         


Ala Gln Leu Leu Ala Tyr Lys Glu Lys Gly His Ser Gln Ser Ser Gln 
        195                 200                 205             


Phe Ser Ser Asp Gln Glu Ile Ala His Leu Leu Pro Glu Asn Val Ser 
    210                 215                 220                 


Ala Leu Pro Ala Thr Val Ala Val Ala Ser Pro His Thr Thr Ser Ala 
225                 230                 235                 240 


Thr Pro Lys Pro Ala Thr Leu Leu Pro Thr Asn Ala Ser Val Thr Pro 
                245                 250                 255     


Ser Gly Thr Ser Gln Pro Gln Leu Ala Thr Thr Ala Pro Pro Val Thr 
            260                 265                 270         


Thr Val Thr Ser Gln Pro Pro Thr Thr Leu Ile Ser Thr Val Phe Thr 
        275                 280                 285             


Arg Ala Ala Ala Thr Leu Gln Ala Met Ala Thr Thr Ala Val Leu Thr 
    290                 295                 300                 


Thr Thr Phe Gln Ala Pro Thr Asp Ser Lys Gly Ser Leu Glu Thr Ile 
305                 310                 315                 320 


Pro Phe Thr Glu Ile Ser Asn Leu Thr Leu Asn Thr Gly Asn Val Tyr 
                325                 330                 335     


Asn Pro Thr Ala Leu Ser Met Ser Asn Val Glu Ser Ser Thr Met Asn 
            340                 345                 350         


Lys Thr Ala Ser Trp Glu Gly Arg Glu Ala Ser Pro Gly Ser Ser Ser 
        355                 360                 365             


Gln Gly Ser Val Pro Glu Asn Gln Tyr Gly Leu Pro Phe Glu Lys Trp 
    370                 375                 380                 


Leu Leu Ile Gly Ser Leu Leu Phe Gly Val Leu Phe Leu Val Ile Gly 
385                 390                 395                 400 


Leu Val Leu Leu Gly Arg Ile Leu Ser Glu Ser Leu Arg Arg Lys Arg 
                405                 410                 415     


Tyr Ser Arg Leu Asp Tyr Leu Ile Asn Gly Ile Tyr Val Asp Ile 
            420                 425                 430     


<210>  4385
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  4385

Met Pro Lys Asn Ser Lys Val Val Lys Arg Glu Leu Asp Asp Asp Val 
1               5                   10                  15      


Thr Glu Ser Val Lys Asp Leu Leu Ser Asn Glu Asp Ala Ala Asp Asp 
            20                  25                  30          


Ala Phe Lys Thr Ser Glu Leu Ile Val Asp Gly Gln Glu Glu Lys Asp 
        35                  40                  45              


Thr Asp Val Glu Glu Gly Ser Glu Val Glu Asp Glu Arg Pro Ala Trp 
    50                  55                  60                  


Asn Ser Lys Leu Gln Tyr Ile Leu Ala Gln Val Gly Phe Ser Val Gly 
65                  70                  75                  80  


Leu Gly Asn Val Trp Arg Phe Pro Tyr Leu Cys Gln Lys Asn Gly Gly 
                85                  90                  95      


Gly Ala Tyr Leu Leu Pro Tyr Leu Ile Leu Leu Met Val Ile Gly Ile 
            100                 105                 110         


Pro Leu Phe Phe Leu Glu Leu Ser Val Gly Gln Arg Ile Arg Arg Gly 
        115                 120                 125             


Ser Ile Gly Val Trp Asn Tyr Ile Ser Pro Lys Leu Gly Gly Ile Gly 
    130                 135                 140                 


Phe Ala Ser Cys Val Val Cys Tyr Phe Val Ala Leu Tyr Tyr Asn Val 
145                 150                 155                 160 


Ile Ile Gly Trp Ser Leu Phe Tyr Phe Ser Gln Ser Phe Gln Gln Pro 
                165                 170                 175     


Leu Pro Trp Asp Gln Cys Pro Leu Val Lys Asn Ala Ser His Thr Phe 
            180                 185                 190         


Val Glu Pro Glu Cys Glu Gln Ser Ser Ala Thr Thr Tyr Tyr Trp Tyr 
        195                 200                 205             


Arg Glu Ala Leu Asn Ile Ser Ser Ser Ile Ser Glu Ser Gly Gly Leu 
    210                 215                 220                 


Asn Trp Lys Met Thr Ile Cys Leu Leu Ala Ala Trp Val Met Val Cys 
225                 230                 235                 240 


Leu Ala Met Ile Lys Gly Ile Gln Ser Ser Gly Lys Val Ser Met Leu 
                245                 250                 255     


Glu Pro Phe Leu Ile Leu Leu Ile Thr Ile Ser Gly Phe Ile Pro Leu 
            260                 265                 270         


Ser Asn Ser Val Thr Asp Phe Cys Gly Gln Ile Thr His Asn Thr Ser 
        275                 280                 285             


Phe 
    


<210>  4386
<211>  546
<212>  PRT
<213>  Homo sapiens

<400>  4386

Met Ala Asn Asn Ser Pro Ala Leu Thr Gly Asn Ser Gln Pro Gln His 
1               5                   10                  15      


Gln Ala Ala Ala Ala Ala Ala Gln Gln Gln Gln Gln Cys Gly Gly Gly 
            20                  25                  30          


Gly Ala Thr Lys Pro Ala Val Ser Gly Lys Gln Gly Asn Val Leu Pro 
        35                  40                  45              


Leu Trp Gly Asn Glu Lys Thr Met Asn Leu Asn Pro Met Ile Leu Thr 
    50                  55                  60                  


Asn Ile Leu Ser Ser Pro Tyr Phe Lys Val Gln Leu Tyr Glu Leu Lys 
65                  70                  75                  80  


Thr Tyr His Glu Val Val Asp Glu Ile Tyr Phe Lys Val Thr His Val 
                85                  90                  95      


Glu Pro Trp Glu Lys Gly Ser Arg Lys Thr Ala Gly Gln Thr Gly Met 
            100                 105                 110         


Cys Gly Gly Val Arg Gly Val Gly Thr Gly Gly Ile Val Ser Thr Ala 
        115                 120                 125             


Phe Cys Leu Leu Tyr Lys Leu Phe Thr Leu Lys Leu Thr Arg Lys Gln 
    130                 135                 140                 


Val Met Gly Leu Ile Thr His Thr Asp Ser Pro Tyr Ile Arg Ala Leu 
145                 150                 155                 160 


Gly Phe Met Tyr Ile Arg Tyr Thr Gln Pro Pro Thr Asp Leu Trp Asp 
                165                 170                 175     


Trp Phe Glu Ser Phe Leu Asp Asp Glu Glu Asp Leu Asp Val Lys Ala 
            180                 185                 190         


Gly Gly Gly Cys Val Met Thr Ile Gly Glu Met Leu Arg Ser Phe Leu 
        195                 200                 205             


Thr Lys Leu Glu Trp Phe Ser Thr Leu Phe Pro Arg Ile Pro Val Pro 
    210                 215                 220                 


Val Gln Lys Asn Ile Asp Gln Gln Ile Lys Thr Arg Pro Arg Lys Ile 
225                 230                 235                 240 


Lys Lys Asp Gly Lys Glu Gly Ala Glu Glu Ile Asp Arg His Val Glu 
                245                 250                 255     


Arg Arg Arg Ser Arg Ser Pro Arg Arg Ser Leu Ser Pro Arg Arg Ser 
            260                 265                 270         


Pro Arg Arg Ser Arg Ser Arg Ser His His Arg Glu Gly His Gly Ser 
        275                 280                 285             


Ser Ser Phe Asp Arg Glu Leu Glu Arg Glu Lys Glu Arg Gln Arg Leu 
    290                 295                 300                 


Glu Arg Glu Ala Lys Glu Arg Glu Lys Glu Arg Arg Arg Ser Arg Ser 
305                 310                 315                 320 


Ile Asp Arg Gly Leu Glu Arg Arg Arg Ser Arg Ser Arg Glu Arg His 
                325                 330                 335     


Arg Ser Arg Ser Arg Ser Arg Asp Arg Lys Gly Asp Arg Arg Asp Arg 
            340                 345                 350         


Asp Arg Glu Arg Glu Lys Glu Asn Glu Arg Gly Arg Arg Arg Asp Arg 
        355                 360                 365             


Asp Tyr Asp Lys Glu Arg Gly Asn Glu Arg Glu Lys Glu Arg Glu Arg 
    370                 375                 380                 


Ser Arg Glu Arg Ser Lys Glu Gln Arg Ser Arg Gly Glu Val Glu Glu 
385                 390                 395                 400 


Lys Lys His Lys Glu Asp Lys Asp Asp Arg Arg His Arg Asp Asp Lys 
                405                 410                 415     


Arg Asp Ser Lys Lys Glu Lys Lys His Ser Arg Ser Arg Ser Arg Glu 
            420                 425                 430         


Arg Lys His Arg Ser Arg Ser Arg Ser Arg Asn Ala Gly Lys Arg Ser 
        435                 440                 445             


Arg Ser Arg Ser Lys Glu Lys Ser Ser Lys His Lys Asn Glu Ser Lys 
    450                 455                 460                 


Glu Lys Ser Asn Lys Arg Ser Arg Ser Gly Ser Gln Gly Arg Thr Asp 
465                 470                 475                 480 


Ser Val Glu Lys Ser Lys Lys Arg Glu His Ser Pro Ser Lys Glu Lys 
                485                 490                 495     


Ser Arg Lys Arg Ser Arg Ser Lys Glu Arg Ser His Lys Arg Asp His 
            500                 505                 510         


Ser Asp Ser Lys Asp Gln Ser Asp Lys His Asp Arg Arg Arg Ser Gln 
        515                 520                 525             


Ser Ile Glu Gln Glu Ser Gln Glu Lys Gln His Lys Asn Lys Asp Glu 
    530                 535                 540                 


Thr Val 
545     


<210>  4387
<211>  973
<212>  PRT
<213>  Homo sapiens

<400>  4387

Met Asp Pro Phe Arg Pro Ser Phe Arg Gly Gln Ser Pro Ile His Pro 
1               5                   10                  15      


Ser Gln Cys Gln Ala Val Arg Met Pro Gly Cys Trp Pro Gln Ala Ser 
            20                  25                  30          


Lys Pro Leu Asp Pro Ala Leu Gly Arg Gly Ala Pro Ala Gly Arg Gly 
        35                  40                  45              


His Val Phe Gly Lys Pro Glu Glu Pro Ser Thr Gln Arg Gly Pro Ala 
    50                  55                  60                  


Gln Arg Glu Ser Val Gly Leu Val Ser Met Phe Arg Gly Leu Gly Ile 
65                  70                  75                  80  


Glu Thr Val Ser Lys Thr Pro Leu Lys Arg Glu Met Leu Pro Ser Gly 
                85                  90                  95      


Arg Gly Ile Leu Gly Arg Gly Leu Ser Ala Asn Leu Val Arg Lys Asp 
            100                 105                 110         


Arg Glu Glu Leu Ser Pro Thr Phe Trp Asp Pro Lys Val Leu Ala Ala 
        115                 120                 125             


Gly Asp Ser Lys Met Ala Glu Thr Ser Val Gly Trp Ser Arg Thr Leu 
    130                 135                 140                 


Gly Arg Gly Ser Ser Asp Ala Ser Leu Leu Pro Leu Gly Arg Ala Ala 
145                 150                 155                 160 


Gly Gly Ile Ser Arg Glu Val Asp Lys Pro Pro Cys Thr Phe Ser Thr 
                165                 170                 175     


Pro Ser Arg Gly Pro Pro Gln Leu Ser Ser Pro Pro Ala Leu Pro Gln 
            180                 185                 190         


Ser Pro Leu His Ser Pro Asp Arg Pro Leu Val Leu Thr Val Glu His 
        195                 200                 205             


Lys Glu Lys Glu Leu Ile Val Lys Gln Gly Ser Lys Gly Thr Pro Gln 
    210                 215                 220                 


Ser Leu Gly Leu Asn Leu Val Lys Ile Gln Cys His Asn Glu Ala Val 
225                 230                 235                 240 


Tyr Gln Tyr His Val Thr Phe Ser Pro Asn Val Glu Cys Lys Ser Met 
                245                 250                 255     


Arg Phe Gly Met Leu Lys Asp His Gln Ala Val Thr Gly Asn Val Thr 
            260                 265                 270         


Ala Phe Asp Gly Ser Ile Leu Tyr Leu Pro Val Lys Leu Gln Gln Val 
        275                 280                 285             


Leu Glu Leu Lys Ser Gln Arg Lys Thr Asp Ser Ala Glu Ile Ser Ile 
    290                 295                 300                 


Lys Ile Gln Met Thr Lys Ile Leu Glu Pro Cys Ser Asp Leu Cys Ile 
305                 310                 315                 320 


Pro Phe Tyr Asn Val Val Phe Arg Arg Val Met Lys Leu Leu Asp Met 
                325                 330                 335     


Lys Leu Val Gly Arg Asn Phe Tyr Asp Pro Thr Ser Ala Met Val Leu 
            340                 345                 350         


Gln Gln His Arg Leu Gln Ile Trp Pro Gly Tyr Ala Ala Ser Ile Arg 
        355                 360                 365             


Arg Thr Asp Gly Gly Leu Phe Leu Leu Ala Asp Val Ser His Lys Val 
    370                 375                 380                 


Ile Arg Asn Asp Cys Val Leu Asp Val Met His Ala Ile Tyr Gln Gln 
385                 390                 395                 400 


Asn Lys Glu His Phe Gln Asp Glu Cys Thr Lys Leu Leu Val Gly Asn 
                405                 410                 415     


Ile Val Ile Thr Arg Tyr Asn Asn Arg Thr Tyr Arg Ile Asp Asp Val 
            420                 425                 430         


Asp Trp Asn Lys Thr Pro Lys Asp Ser Phe Thr Met Ser Asp Gly Lys 
        435                 440                 445             


Glu Ile Thr Phe Leu Glu Tyr Tyr Ser Lys Asn Tyr Gly Ile Thr Val 
    450                 455                 460                 


Lys Glu Glu Asp Gln Pro Leu Leu Ile His Arg Pro Ser Glu Arg Gln 
465                 470                 475                 480 


Asp Asn His Gly Met Leu Leu Lys Gly Glu Ile Leu Leu Leu Pro Glu 
                485                 490                 495     


Leu Ser Phe Met Thr Gly Ile Pro Glu Lys Met Lys Lys Asp Phe Arg 
            500                 505                 510         


Ala Met Lys Asp Leu Ala Gln Gln Ile Asn Leu Ser Pro Lys Gln His 
        515                 520                 525             


His Ser Ala Leu Glu Cys Leu Leu Gln Arg Ile Ala Lys Asn Glu Ala 
    530                 535                 540                 


Ala Thr Asn Glu Leu Met Arg Trp Gly Leu Arg Leu Gln Lys Asp Val 
545                 550                 555                 560 


His Lys Ile Glu Gly Arg Val Leu Pro Met Glu Arg Ile Asn Leu Lys 
                565                 570                 575     


Asn Thr Ser Phe Ile Thr Ser Gln Glu Leu Asn Trp Val Lys Glu Val 
            580                 585                 590         


Thr Arg Asp Pro Ser Ile Leu Thr Ile Pro Met His Phe Trp Ala Leu 
        595                 600                 605             


Phe Tyr Pro Lys Arg Ala Met Asp Gln Ala Arg Glu Leu Val Asn Met 
    610                 615                 620                 


Leu Glu Lys Ile Ala Gly Pro Ile Gly Met Arg Met Ser Pro Pro Ala 
625                 630                 635                 640 


Trp Val Glu Leu Lys Asp Asp Arg Ile Glu Thr Tyr Val Arg Thr Ile 
                645                 650                 655     


Gln Ser Thr Leu Gly Ala Glu Gly Lys Ile Gln Met Val Val Cys Ile 
            660                 665                 670         


Ile Met Gly Pro Arg Asp Asp Leu Tyr Gly Ala Ile Lys Lys Leu Cys 
        675                 680                 685             


Cys Val Gln Ser Pro Val Pro Ser Gln Val Val Asn Val Arg Thr Ile 
    690                 695                 700                 


Gly Gln Pro Thr Arg Leu Arg Ser Val Ala Gln Lys Ile Leu Leu Gln 
705                 710                 715                 720 


Ile Asn Cys Lys Leu Gly Gly Glu Leu Trp Gly Val Asp Ile Pro Leu 
                725                 730                 735     


Lys Gln Leu Met Val Ile Gly Met Asp Val Tyr His Asp Pro Ser Arg 
            740                 745                 750         


Gly Met Arg Ser Val Val Gly Phe Val Ala Ser Ile Asn Leu Thr Leu 
        755                 760                 765             


Thr Lys Trp Tyr Ser Arg Val Val Phe Gln Met Pro His Gln Glu Ile 
    770                 775                 780                 


Val Asp Ser Leu Lys Leu Cys Leu Val Gly Ser Leu Lys Lys Phe Tyr 
785                 790                 795                 800 


Glu Val Asn His Cys Leu Pro Glu Lys Ile Val Val Tyr Arg Asp Gly 
                805                 810                 815     


Val Ser Asp Gly Gln Leu Lys Thr Val Ala Asn Tyr Glu Ile Pro Gln 
            820                 825                 830         


Leu Gln Lys Cys Phe Glu Ala Phe Glu Asn Tyr Gln Pro Lys Met Val 
        835                 840                 845             


Val Phe Val Val Gln Lys Lys Ile Ser Thr Asn Leu Tyr Leu Ala Ala 
    850                 855                 860                 


Pro Gln Asn Phe Val Thr Pro Thr Pro Gly Thr Val Val Asp His Thr 
865                 870                 875                 880 


Ile Thr Ser Cys Glu Trp Val Asp Phe Tyr Leu Leu Ala His His Val 
                885                 890                 895     


Arg Gln Gly Cys Gly Ile Pro Thr His Tyr Val Cys Val Leu Asn Thr 
            900                 905                 910         


Ala Asn Leu Ser Pro Asp His Met Gln Arg Leu Thr Phe Lys Leu Cys 
        915                 920                 925             


His Met Tyr Trp Asn Trp Pro Gly Thr Ile Arg Val Pro Ala Pro Cys 
    930                 935                 940                 


Lys Tyr Ala His Lys Leu Ala Phe Leu Ser Gly His Ile Leu His His 
945                 950                 955                 960 


Glu Pro Ala Ile Gln Leu Cys Glu Asn Leu Phe Phe Leu 
                965                 970             


<210>  4388
<211>  660
<212>  PRT
<213>  Homo sapiens

<400>  4388

Met Lys Val Thr Leu Ser Ala Leu Asp Thr Ser Glu Ser Ser Phe Thr 
1               5                   10                  15      


Pro Leu Val Val Ile Glu Leu Ala Gln Asp Val Lys Glu Glu Thr Lys 
            20                  25                  30          


Glu Trp Leu Lys Asn Arg Ile Ile Ala Lys Lys Lys Asp Gly Gly Ala 
        35                  40                  45              


Gln Leu Leu Phe Arg Pro Leu Leu Asn Lys Tyr Glu Gln Glu Thr Leu 
    50                  55                  60                  


Glu Asn Gln Asn Leu Tyr Leu Val Gly Ala Ser Lys Ile Arg Met Leu 
65                  70                  75                  80  


Leu Gly Ala Glu Ala Val Gly Leu Val Lys Glu Cys Asn Asp Asn Thr 
                85                  90                  95      


Met Arg Ala Phe Thr Tyr Arg Thr Arg Gln Asn Phe Lys Gly Phe Asp 
            100                 105                 110         


Asp Asn Asn Asp Asp Phe Leu Thr Met Ala Glu Cys Gln Phe Ile Ile 
        115                 120                 125             


Lys His Glu Leu Glu Asn Leu Arg Ala Lys Asp Glu Lys Met Ile Pro 
    130                 135                 140                 


Gly Tyr Pro Gln Ala Lys Leu Tyr Pro Gly Lys Ser Leu Leu Arg Arg 
145                 150                 155                 160 


Leu Leu Thr Ser Gly Ile Val Ile Gln Val Phe Pro Leu His Asp Ser 
                165                 170                 175     


Glu Ala Leu Lys Lys Leu Glu Asp Thr Trp Tyr Thr Arg Phe Ala Leu 
            180                 185                 190         


Lys Tyr Gln Pro Ile Asp Ser Ile Arg Gly Tyr Phe Gly Glu Thr Ile 
        195                 200                 205             


Ala Leu Tyr Phe Gly Phe Leu Glu Tyr Phe Thr Phe Ala Leu Ile Pro 
    210                 215                 220                 


Met Ala Val Ile Gly Leu Pro Tyr Tyr Leu Phe Val Trp Glu Asp Tyr 
225                 230                 235                 240 


Asp Lys Tyr Val Ile Phe Ala Ser Phe Asn Leu Ile Trp Ser Thr Val 
                245                 250                 255     


Ile Leu Glu Leu Trp Lys Arg Gly Cys Ala Asn Met Thr Tyr Arg Trp 
            260                 265                 270         


Gly Thr Leu Leu Met Lys Arg Lys Phe Glu Glu Pro Arg Pro Gly Phe 
        275                 280                 285             


His Gly Val Leu Gly Ile Asn Ser Ile Thr Gly Lys Glu Glu Pro Leu 
    290                 295                 300                 


Tyr Pro Ser Tyr Lys Arg Gln Leu Arg Ile Tyr Leu Val Ser Leu Pro 
305                 310                 315                 320 


Phe Val Cys Leu Cys Leu Tyr Phe Ser Leu Tyr Val Met Met Ile Tyr 
                325                 330                 335     


Phe Asp Met Glu Val Trp Ala Leu Gly Leu His Glu Asn Ser Gly Ser 
            340                 345                 350         


Glu Trp Thr Ser Val Leu Leu Tyr Val Pro Ser Ile Ile Tyr Ala Ile 
        355                 360                 365             


Val Ile Glu Ile Met Asn Arg Leu Tyr Arg Tyr Ala Ala Glu Phe Leu 
    370                 375                 380                 


Thr Ser Trp Glu Asn His Arg Leu Glu Ser Ala Tyr Gln Asn His Leu 
385                 390                 395                 400 


Ile Leu Lys Val Leu Val Phe Asn Phe Leu Asn Cys Phe Ala Ser Leu 
                405                 410                 415     


Phe Tyr Ile Ala Phe Val Leu Lys Asp Met Lys Leu Leu Arg Gln Ser 
            420                 425                 430         


Leu Ala Thr Leu Leu Ile Thr Ser Gln Ile Leu Asn Gln Ile Met Glu 
        435                 440                 445             


Ser Phe Leu Pro Tyr Trp Leu Gln Arg Lys His Gly Val Arg Val Lys 
    450                 455                 460                 


Arg Lys Val Gln Ala Leu Lys Ala Asp Ile Asp Ala Thr Leu Tyr Glu 
465                 470                 475                 480 


Gln Val Ile Leu Glu Lys Glu Met Gly Thr Tyr Leu Gly Thr Phe Asp 
                485                 490                 495     


Asp Tyr Leu Glu Leu Phe Leu Gln Phe Gly Tyr Val Ser Leu Phe Ser 
            500                 505                 510         


Cys Val Tyr Pro Leu Ala Ala Ala Phe Ala Val Leu Asn Asn Phe Thr 
        515                 520                 525             


Glu Val Asn Ser Asp Ala Leu Lys Met Cys Arg Val Phe Lys Arg Pro 
    530                 535                 540                 


Phe Ser Glu Pro Ser Ala Asn Ile Gly Val Trp Gln Leu Ala Phe Glu 
545                 550                 555                 560 


Thr Met Ser Val Ile Ser Val Val Thr Asn Cys Ala Leu Ile Gly Met 
                565                 570                 575     


Ser Pro Gln Val Asn Ala Val Phe Pro Glu Ser Lys Ala Asp Leu Ile 
            580                 585                 590         


Leu Ile Val Val Ala Val Glu His Ala Leu Leu Ala Leu Lys Phe Ile 
        595                 600                 605             


Leu Ala Phe Ala Ile Pro Asp Lys Pro Arg His Ile Gln Met Lys Leu 
    610                 615                 620                 


Ala Arg Leu Glu Phe Glu Ser Leu Glu Ala Leu Lys Gln Gln Gln Met 
625                 630                 635                 640 


Lys Leu Val Thr Glu Asn Leu Lys Glu Glu Pro Met Glu Ser Gly Lys 
                645                 650                 655     


Glu Lys Ala Thr 
            660 


<210>  4389
<211>  674
<212>  PRT
<213>  Homo sapiens

<400>  4389

Met Ala Thr Ala Val Ser Arg Pro Cys Ala Gly Arg Ser Arg Asp Ile 
1               5                   10                  15      


Leu Trp Arg Val Leu Gly Trp Arg Ile Val Ala Ser Ile Val Trp Ser 
            20                  25                  30          


Val Leu Phe Leu Pro Ile Cys Thr Thr Val Phe Ile Ile Phe Ser Arg 
        35                  40                  45              


Ile Asp Leu Phe His Pro Ile Gln Trp Leu Ser Asp Ser Phe Ser Asp 
    50                  55                  60                  


Leu Tyr Ser Ser Tyr Val Ile Phe Tyr Phe Leu Leu Leu Ser Val Val 
65                  70                  75                  80  


Ile Ile Ile Ile Ser Ile Phe Asn Val Glu Phe Tyr Ala Val Val Pro 
                85                  90                  95      


Ser Ile Pro Cys Ser Arg Leu Ala Leu Ile Gly Lys Ile Ile His Pro 
            100                 105                 110         


Gln Gln Leu Met His Ser Phe Ile His Ala Ala Met Gly Met Val Met 
        115                 120                 125             


Ala Trp Cys Ala Ala Val Ile Thr Gln Gly Gln Tyr Ser Phe Leu Val 
    130                 135                 140                 


Val Pro Cys Thr Gly Thr Asn Ser Phe Gly Ser Pro Ala Ala Gln Thr 
145                 150                 155                 160 


Cys Leu Asn Glu Tyr His Leu Phe Phe Leu Leu Thr Gly Ala Phe Met 
                165                 170                 175     


Gly Tyr Ser Tyr Ser Leu Leu Tyr Phe Val Asn Asn Met Asn Tyr Leu 
            180                 185                 190         


Pro Phe Pro Ile Ile Gln Gln Tyr Lys Phe Leu Arg Phe Arg Arg Ser 
        195                 200                 205             


Leu Leu Leu Leu Val Lys His Ser Cys Val Glu Ser Leu Phe Leu Val 
    210                 215                 220                 


Arg Asn Phe Cys Ile Leu Tyr Tyr Phe Leu Gly Tyr Ile Pro Lys Ala 
225                 230                 235                 240 


Trp Ile Ser Thr Ala Met Asn Leu His Ile Asp Glu Gln Val His Arg 
                245                 250                 255     


Pro Leu Asp Thr Val Ser Gly Leu Leu Asn Leu Ser Leu Leu Tyr His 
            260                 265                 270         


Val Trp Leu Cys Gly Val Phe Leu Leu Thr Thr Trp Tyr Val Ser Trp 
        275                 280                 285             


Ile Leu Phe Lys Ile Tyr Ala Thr Glu Ala His Val Phe Pro Val Gln 
    290                 295                 300                 


Pro Pro Phe Ala Glu Gly Ser Asp Glu Cys Leu Pro Lys Val Leu Asn 
305                 310                 315                 320 


Ser Asn Pro Pro Pro Ile Ile Lys Tyr Leu Ala Leu Gln Asp Leu Met 
                325                 330                 335     


Leu Leu Ser Gln Tyr Ser Pro Ser Arg Arg Gln Glu Val Phe Ser Leu 
            340                 345                 350         


Ser Gln Pro Gly Gly His Pro His Asn Trp Thr Ala Ile Ser Arg Glu 
        355                 360                 365             


Cys Leu Asn Leu Leu Asn Gly Met Thr Gln Lys Leu Ile Leu Tyr Gln 
    370                 375                 380                 


Glu Ala Ala Ala Thr Asn Gly Arg Val Ser Ser Ser Tyr Pro Val Glu 
385                 390                 395                 400 


Pro Lys Lys Leu Asn Ser Pro Glu Glu Thr Ala Phe Gln Thr Pro Lys 
                405                 410                 415     


Ser Ser Gln Met Pro Arg Pro Ser Val Pro Pro Leu Val Lys Thr Ser 
            420                 425                 430         


Leu Phe Ser Ser Lys Leu Ser Thr Pro Asp Val Val Ser Pro Phe Gly 
        435                 440                 445             


Thr Pro Phe Gly Ser Ser Val Met Asn Arg Met Ala Gly Ile Phe Asp 
    450                 455                 460                 


Val Asn Thr Cys Tyr Gly Ser Pro Gln Ser Pro Gln Leu Ile Arg Arg 
465                 470                 475                 480 


Gly Pro Arg Leu Trp Thr Ser Ala Ser Asp Gln Gln Met Thr Glu Phe 
                485                 490                 495     


Ser Asn Pro Ser Pro Ser Thr Ser Ile Ser Ala Glu Gly Lys Thr Met 
            500                 505                 510         


Arg Gln Pro Ser Val Ile Tyr Ser Trp Ile Gln Asn Lys Arg Glu Gln 
        515                 520                 525             


Ile Lys Asn Phe Leu Ser Lys Arg Val Leu Ile Met Tyr Phe Phe Ser 
    530                 535                 540                 


Lys His Pro Glu Ala Ser Ile Gln Ala Val Phe Ser Asp Ala Gln Met 
545                 550                 555                 560 


His Ile Trp Ala Leu Glu Gly Leu Ser His Leu Val Ala Ala Ser Phe 
                565                 570                 575     


Thr Glu Asp Arg Phe Gly Val Val Gln Thr Thr Leu Pro Ala Ile Leu 
            580                 585                 590         


Asn Thr Leu Leu Thr Leu Gln Glu Ala Val Asp Lys Tyr Phe Lys Leu 
        595                 600                 605             


Pro His Ala Ser Ser Lys Pro Pro Arg Ile Ser Gly Ser Leu Val Asp 
    610                 615                 620                 


Thr Ser Tyr Lys Thr Leu Arg Phe Ala Phe Arg Ala Ser Leu Lys Thr 
625                 630                 635                 640 


Ala Ile Tyr Arg Ile Thr Thr Thr Phe Gly Glu His Leu Asn Ala Val 
                645                 650                 655     


Gln Ala Ser Ala Glu His Gln Lys Arg Leu Gln Gln Phe Leu Glu Phe 
            660                 665                 670         


Lys Glu 
        


<210>  4390
<211>  525
<212>  PRT
<213>  Homo sapiens

<400>  4390

Met Ala Leu Glu Arg Leu Cys Ser Val Leu Lys Val Leu Leu Ile Thr 
1               5                   10                  15      


Val Leu Val Val Glu Gly Ile Ala Val Ala Gln Lys Thr Gln Asp Gly 
            20                  25                  30          


Gln Asn Ile Gly Ile Lys His Ile Pro Ala Thr Gln Cys Gly Ile Trp 
        35                  40                  45              


Val Arg Thr Ser Asn Gly Gly His Phe Ala Ser Pro Asn Tyr Pro Asp 
    50                  55                  60                  


Ser Tyr Pro Pro Asn Lys Glu Cys Ile Tyr Ile Leu Glu Ala Ala Pro 
65                  70                  75                  80  


Arg Gln Arg Ile Glu Leu Thr Phe Asp Glu His Tyr Tyr Ile Glu Pro 
                85                  90                  95      


Ser Phe Glu Cys Arg Phe Asp His Leu Glu Val Arg Asp Gly Pro Phe 
            100                 105                 110         


Gly Phe Ser Pro Leu Ile Asp Arg Tyr Cys Gly Val Lys Ser Pro Pro 
        115                 120                 125             


Leu Ile Arg Ser Thr Gly Arg Phe Met Trp Ile Lys Phe Ser Ser Asp 
    130                 135                 140                 


Glu Glu Leu Glu Gly Leu Gly Phe Arg Ala Lys Tyr Ser Phe Ile Pro 
145                 150                 155                 160 


Asp Pro Asp Phe Thr Tyr Leu Gly Gly Ile Leu Asn Pro Ile Pro Asp 
                165                 170                 175     


Cys Gln Phe Glu Leu Ser Gly Ala Asp Gly Ile Val Arg Ser Ser Gln 
            180                 185                 190         


Val Glu Gln Glu Glu Lys Thr Lys Pro Gly Gln Ala Val Asp Cys Ile 
        195                 200                 205             


Trp Thr Ile Lys Ala Thr Pro Lys Ala Lys Ile Tyr Leu Arg Phe Leu 
    210                 215                 220                 


Asp Tyr Gln Met Glu His Ser Asn Glu Cys Lys Arg Asn Phe Val Ala 
225                 230                 235                 240 


Val Tyr Asp Gly Ser Ser Ser Ile Glu Asn Leu Lys Ala Lys Phe Cys 
                245                 250                 255     


Ser Thr Val Ala Asn Asp Val Met Leu Lys Thr Gly Ile Gly Val Ile 
            260                 265                 270         


Arg Met Trp Ala Asp Glu Gly Ser Arg Leu Ser Arg Phe Arg Met Leu 
        275                 280                 285             


Phe Thr Ser Phe Val Glu Pro Pro Cys Thr Ser Ser Thr Phe Phe Cys 
    290                 295                 300                 


His Ser Asn Met Cys Ile Asn Asn Ser Leu Val Cys Asn Gly Val Gln 
305                 310                 315                 320 


Asn Cys Ala Tyr Pro Trp Asp Glu Asn His Cys Lys Glu Lys Lys Lys 
                325                 330                 335     


Ala Gly Val Phe Glu Gln Ile Thr Lys Thr His Gly Thr Ile Ile Gly 
            340                 345                 350         


Ile Thr Ser Gly Ile Val Leu Val Leu Leu Ile Ile Ser Ile Leu Val 
        355                 360                 365             


Gln Val Lys Gln Pro Arg Lys Lys Val Met Ala Cys Lys Thr Ala Phe 
    370                 375                 380                 


Asn Lys Thr Gly Phe Gln Glu Val Phe Asp Pro Pro His Tyr Glu Leu 
385                 390                 395                 400 


Phe Ser Leu Arg Asp Lys Glu Ile Ser Ala Asp Leu Ala Asp Leu Ser 
                405                 410                 415     


Glu Glu Leu Asp Asn Tyr Gln Lys Met Arg Arg Ser Ser Thr Ala Ser 
            420                 425                 430         


Arg Cys Ile His Asp His His Cys Gly Ser Gln Ala Ser Ser Val Lys 
        435                 440                 445             


Gln Ser Arg Thr Asn Leu Ser Ser Met Glu Leu Pro Phe Arg Asn Asp 
    450                 455                 460                 


Phe Ala Gln Pro Gln Pro Met Lys Thr Phe Asn Ser Thr Phe Lys Lys 
465                 470                 475                 480 


Ser Ser Tyr Thr Phe Lys Gln Gly His Glu Cys Pro Glu Gln Ala Leu 
                485                 490                 495     


Glu Asp Arg Val Met Glu Glu Ile Pro Cys Glu Ile Tyr Val Arg Gly 
            500                 505                 510         


Arg Glu Asp Ser Ala Gln Ala Ser Ile Ser Ile Asp Phe 
        515                 520                 525 


<210>  4391
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  4391

Met Ser Thr Ile Ala Ala Phe Tyr Gly Gly Lys Ser Ile Leu Ile Thr 
1               5                   10                  15      


Gly Ala Thr Gly Phe Leu Gly Lys Val Leu Met Glu Lys Leu Phe Arg 
            20                  25                  30          


Thr Ser Pro Asp Leu Lys Val Ile Tyr Ile Leu Val Arg Pro Lys Ala 
        35                  40                  45              


Gly Gln Thr Leu Gln Gln Arg Val Phe Gln Ile Leu Asp Ser Lys Leu 
    50                  55                  60                  


Phe Glu Lys Val Lys Glu Val Cys Pro Asn Val His Glu Lys Ile Arg 
65                  70                  75                  80  


Ala Ile Tyr Ala Asp Leu Asn Gln Asn Asp Phe Ala Ile Ser Lys Glu 
                85                  90                  95      


Asp Met Gln Glu Leu Leu Ser Cys Thr Asn Ile Ile Phe His Cys Ala 
            100                 105                 110         


Ala Thr Val Arg Phe Asp Asp Thr Leu Arg His Ala Val Gln Leu Asn 
        115                 120                 125             


Val Thr Ala Thr Arg Gln Leu Leu Leu Met Ala Ser Gln Met Pro Lys 
    130                 135                 140                 


Leu Glu Ala Phe Ile His Ile Ser Thr Ala Tyr Ser Asn Cys Asn Leu 
145                 150                 155                 160 


Lys His Ile Asp Glu Val Ile Tyr Pro Cys Pro Val Glu Pro Lys Lys 
                165                 170                 175     


Ile Ile Asp Ser Leu Glu Trp Leu Asp Asp Ala Ile Ile Asp Glu Ile 
            180                 185                 190         


Thr Pro Lys Leu Ile Arg Asp Trp Pro Asn Ile Tyr Thr Tyr Thr Lys 
        195                 200                 205             


Ala Leu Gly Glu Met Val Val Gln Gln Glu Ser Arg Asn Leu Asn Ile 
    210                 215                 220                 


Ala Ile Ile Arg Pro Ser Ile Val Gly Ala Thr Trp Gln Glu Pro Phe 
225                 230                 235                 240 


Pro Gly Trp Val Asp Asn Ile Asn Gly Pro Asn Gly Ile Ile Ile Ala 
                245                 250                 255     


Thr Gly Lys Gly Phe Leu Arg Ala Ile Lys Ala Thr Pro Met Ala Val 
            260                 265                 270         


Ala Asp Val Ile Pro Val Asp Thr Val Val Asn Leu Met Leu Ala Val 
        275                 280                 285             


Gly Trp Tyr Thr Ala Val His Arg Pro Lys Ser Thr Leu Val Tyr His 
    290                 295                 300                 


Ile Thr Ser Gly Asn Met Asn Pro Cys Asn Trp His Lys Met Gly Val 
305                 310                 315                 320 


Gln Val Leu Ala Thr Phe Glu Lys Ile Pro Phe Glu Arg Pro Phe Arg 
                325                 330                 335     


Arg Pro Asn Ala Asn Phe Thr Ser Asn Ser Phe Thr Ser Gln Tyr Trp 
            340                 345                 350         


Asn Ala Val Ser His Arg Ala Pro Ala Ile Ile Tyr Asp Cys Tyr Leu 
        355                 360                 365             


Arg Leu Thr Gly Arg Lys Pro Arg Met Thr Lys Leu Met Asn Arg Leu 
    370                 375                 380                 


Leu Arg Thr Val Ser Met Leu Glu Tyr Phe Ile Asn Arg Ser Trp Glu 
385                 390                 395                 400 


Trp Ser Thr Tyr Asn Thr Glu Met Leu Met Ser Glu Leu Ser Pro Glu 
                405                 410                 415     


Asp Gln Arg Val Phe Asn Phe Asp Val Arg Gln Leu Asn Trp Leu Glu 
            420                 425                 430         


Tyr Ile Glu Asn Tyr Val Leu Gly Val Lys Lys Tyr Leu Leu Lys Glu 
        435                 440                 445             


Asp Met Ala Gly Ile Pro Lys Ala Lys Gln Arg Leu Lys Arg Leu Arg 
    450                 455                 460                 


Asn Ile His Tyr Leu Phe Asn Thr Ala Leu Phe Leu Ile Ala Trp Arg 
465                 470                 475                 480 


Leu Leu Ile Ala Arg Ser Gln Met Ala Arg Asn Val Trp Phe Phe Ile 
                485                 490                 495     


Val Ser Phe Cys Tyr Lys Phe Leu Ser Tyr Phe Arg Ala Ser Ser Thr 
            500                 505                 510         


Leu Lys Val 
        515 


<210>  4392
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  4392

Met Phe Thr Leu Ala Glu Val Ala Ser Leu Asn Asp Ile Gln Pro Thr 
1               5                   10                  15      


Tyr Arg Ile Leu Lys Pro Trp Trp Asp Val Phe Met Asp Tyr Leu Ala 
            20                  25                  30          


Val Val Met Leu Met Val Ala Ile Phe Ala Gly Thr Met Gln Leu Thr 
        35                  40                  45              


Lys Asp Gln Val Val Cys Leu Pro Val Leu Pro Ser Pro Val Asn Ser 
    50                  55                  60                  


Lys Ala His Thr Pro Pro Gly Asn Ala Glu Val Thr Thr Asn Ile Pro 
65                  70                  75                  80  


Lys Met Glu Ala Ala Thr Asn Gln Asp Gln Asp Gly Arg Thr Thr Asn 
                85                  90                  95      


Asp Ile Ser Phe Gly Thr Ser Ala Val Thr Pro Asp Ile Pro Leu Arg 
            100                 105                 110         


Ala Thr Tyr Pro Arg Thr Asp Phe Ala Leu Pro Asn Gln Glu Ala Lys 
        115                 120                 125             


Lys Glu Lys Lys Asp Pro Thr Gly Arg Lys Thr Asn Leu Asp Phe Gln 
    130                 135                 140                 


Gln Tyr Val Phe Ile Asn Gln Met Cys Tyr His Leu Ala Leu Pro Trp 
145                 150                 155                 160 


Tyr Ser Lys Tyr Phe Pro Tyr Leu Ala Leu Ile His Thr Ile Ile Leu 
                165                 170                 175     


Met Val Ser Ser Asn Phe Trp Phe Lys Tyr Pro Lys Thr Cys Ser Lys 
            180                 185                 190         


Val Glu His Phe Val Ser Ile Leu Gly Lys Cys Phe Glu Ser Pro Trp 
        195                 200                 205             


Thr Thr Lys Ala Leu Ser Glu Thr Ala Cys Glu Asp Ser Glu Glu Asn 
    210                 215                 220                 


Lys Gln Arg Ile Thr Gly Ala Gln Thr Leu Pro Lys His Val Ser Thr 
225                 230                 235                 240 


Ser Ser Asp Glu Gly Ser Pro Ser Ala Ser Thr Pro Met Ile Asn Lys 
                245                 250                 255     


Thr Gly Phe Lys Phe Ser Ala Glu Lys Pro Val Ile Glu Val Pro Ser 
            260                 265                 270         


Met Thr Ile Leu Asp Lys Lys Asp Gly Glu Gln Ala Lys Ala Leu Phe 
        275                 280                 285             


Glu Lys Val Arg Lys Phe Arg Ala His Val Glu Asp Ser Asp Leu Ile 
    290                 295                 300                 


Tyr Lys Leu Tyr Val Val Gln Thr Val Ile Lys Thr Ala Lys Phe Ile 
305                 310                 315                 320 


Phe Ile Leu Cys Tyr Thr Ala Asn Phe Val Asn Ala Ile Ser Phe Glu 
                325                 330                 335     


His Val Cys Lys Pro Lys Val Glu His Leu Ile Gly Tyr Glu Val Phe 
            340                 345                 350         


Glu Cys Thr His Asn Met Ala Tyr Met Leu Lys Lys Leu Leu Ile Ser 
        355                 360                 365             


Tyr Ile Ser Ile Ile Cys Val Tyr Gly Phe Ile Cys Leu Tyr Thr Leu 
    370                 375                 380                 


Phe Trp Leu Phe Arg Ile Pro Leu Lys Glu Tyr Ser Phe Glu Lys Val 
385                 390                 395                 400 


Arg Glu Glu Ser Ser Phe Ser Asp Ile Pro Asp Val Lys Asn Asp Phe 
                405                 410                 415     


Ala Phe Leu Leu His Met Val Asp Gln Tyr Asp Gln Leu Tyr Ser Lys 
            420                 425                 430         


Arg Phe Gly Val Phe Leu Ser Glu Val Ser Glu Asn Lys Leu Arg Glu 
        435                 440                 445             


Ile Ser Leu Asn His Glu Trp Thr Phe Glu Lys Leu Arg Gln His Ile 
    450                 455                 460                 


Ser Arg Asn Ala Gln Asp Lys Gln Glu Leu His Leu Phe Met Leu Ser 
465                 470                 475                 480 


Gly Val Pro Asp Ala Val Phe Asp Leu Thr Asp Leu Asp Val Leu Lys 
                485                 490                 495     


Leu Glu Leu Ile Pro Glu Ala Lys Ile Pro Ala Lys Ile Ser Gln Met 
            500                 505                 510         


Thr Asn Leu Gln Glu Leu His Leu Cys His Cys Pro Ala Lys Val Glu 
        515                 520                 525             


Gln Thr Ala Phe Ser Phe Leu Arg Asp His Leu Arg Cys Leu His Val 
    530                 535                 540                 


Lys Phe Thr Asp Val Ala Glu Ile Pro Ala Trp Val Tyr Leu Leu Lys 
545                 550                 555                 560 


Asn Leu Arg Glu Leu Tyr Leu Ile Gly Asn Leu Asn Ser Glu Asn Asn 
                565                 570                 575     


Lys Met Ile Gly Leu Glu Ser Leu Arg Glu Leu Arg His Leu Lys Ile 
            580                 585                 590         


Leu His Val Lys Ser Asn Leu Thr Lys Val Pro Ser Asn Ile Thr Asp 
        595                 600                 605             


Val Ala Pro His Leu Thr Lys Leu Val Ile His Asn Asp Gly Thr Lys 
    610                 615                 620                 


Leu Leu Val Leu Asn Ser Leu Lys Lys Met Met Asn Val Ala Glu Leu 
625                 630                 635                 640 


Glu Leu Gln Asn Cys Glu Leu Glu Arg Ile Pro His Ala Ile Phe Ser 
                645                 650                 655     


Leu Ser Asn Leu Gln Glu Leu Asp Leu Lys Ser Asn Asn Ile Arg Thr 
            660                 665                 670         


Ile Glu Glu Ile Ile Ser Phe Gln His Leu Lys Arg Leu Thr Cys Leu 
        675                 680                 685             


Lys Leu Trp His Asn Lys Ile Val Thr Ile Pro Pro Ser Ile Thr His 
    690                 695                 700                 


Val Lys Asn Leu Glu Ser Leu Tyr Phe Ser Asn Asn Lys Leu Glu Ser 
705                 710                 715                 720 


Leu Pro Val Ala Val Phe Ser Leu Gln Lys Leu Arg Cys Leu Asp Val 
                725                 730                 735     


Ser Tyr Asn Asn Ile Ser Met Ile Pro Ile Glu Ile Gly Leu Leu Gln 
            740                 745                 750         


Asn Leu Gln His Leu His Ile Thr Gly Asn Lys Val Asp Ile Leu Pro 
        755                 760                 765             


Lys Gln Leu Phe Lys Cys Ile Lys Leu Arg Thr Leu Asn Leu Gly Gln 
    770                 775                 780                 


Asn Cys Ile Thr Ser Leu Pro Glu Lys Val Gly Gln Leu Ser Gln Leu 
785                 790                 795                 800 


Thr Gln Leu Glu Leu Lys Gly Asn Cys Leu Asp Arg Leu Pro Ala Gln 
                805                 810                 815     


Leu Gly Gln Cys Arg Met Leu Lys Lys Ser Gly Leu Val Val Glu Asp 
            820                 825                 830         


His Leu Phe Asp Thr Leu Pro Leu Glu Val Lys Glu Ala Leu Asn Gln 
        835                 840                 845             


Asp Ile Asn Ile Pro Phe Ala Asn Gly Ile 
    850                 855             


<210>  4393
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  4393

Met Asp Phe Leu Val Leu Phe Leu Phe Tyr Leu Ala Ser Val Leu Met 
1               5                   10                  15      


Gly Leu Val Leu Ile Cys Val Cys Ser Lys Thr His Ser Leu Lys Gly 
            20                  25                  30          


Leu Ala Arg Gly Gly Ala Gln Ile Phe Ser Cys Ile Ile Pro Glu Cys 
        35                  40                  45              


Leu Gln Arg Ala Val His Gly Leu Leu His Tyr Leu Phe His Thr Arg 
    50                  55                  60                  


Asn His Thr Phe Ile Val Leu His Leu Val Leu Gln Gly Met Val Tyr 
65                  70                  75                  80  


Thr Glu Tyr Thr Trp Glu Val Phe Gly Tyr Cys Gln Glu Leu Glu Leu 
                85                  90                  95      


Ser Leu His Tyr Leu Leu Leu Pro Tyr Leu Leu Leu Gly Val Asn Leu 
            100                 105                 110         


Phe Phe Phe Thr Leu Thr Cys Gly Thr Asn Pro Gly Ile Ile Thr Lys 
        115                 120                 125             


Ala Asn Glu Leu Leu Phe Leu His Val Tyr Glu Phe Asp Glu Val Met 
    130                 135                 140                 


Phe Pro Lys Asn Val Arg Cys Ser Thr Cys Asp Leu Arg Lys Pro Ala 
145                 150                 155                 160 


Arg Ser Lys His Cys Ser Val Cys Asn Trp Cys Val His Arg Phe Asp 
                165                 170                 175     


His His Cys Val Trp Val Asn Asn Cys Ile Gly Ala Trp Asn Ile Arg 
            180                 185                 190         


Tyr Phe Leu Ile Tyr Val Leu Thr Leu Thr Ala Ser Ala Ala Thr Val 
        195                 200                 205             


Ala Ile Val Ser Thr Thr Phe Leu Val His Leu Val Val Met Ser Asp 
    210                 215                 220                 


Leu Tyr Gln Glu Thr Tyr Ile Asp Asp Leu Gly His Leu His Val Met 
225                 230                 235                 240 


Asp Thr Val Phe Leu Ile Gln Tyr Leu Phe Leu Thr Phe Pro Arg Ile 
                245                 250                 255     


Val Phe Met Leu Gly Phe Val Val Val Leu Ser Phe Leu Leu Gly Gly 
            260                 265                 270         


Tyr Leu Leu Phe Val Leu Tyr Leu Ala Ala Thr Asn Gln Thr Thr Asn 
        275                 280                 285             


Glu Trp Tyr Arg Gly Asp Trp Ala Trp Cys Gln Arg Cys Pro Leu Val 
    290                 295                 300                 


Ala Trp Pro Pro Ser Ala Glu Pro Gln Val His Arg Asn Ile His Ser 
305                 310                 315                 320 


His Gly Leu Arg Ser Asn Leu Gln Glu Ile Phe Leu Pro Ala Phe Pro 
                325                 330                 335     


Cys His Glu Arg Lys Lys Gln Glu 
            340                 


<210>  4394
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  4394

Met Asp Ser Pro Trp Asp Glu Leu Ala Leu Ala Phe Ser Arg Thr Ser 
1               5                   10                  15      


Met Phe Pro Phe Phe Asp Ile Ala His Tyr Leu Val Ser Val Met Ala 
            20                  25                  30          


Val Lys Arg Gln Pro Gly Ala Ala Ala Leu Ala Trp Lys Asn Pro Ile 
        35                  40                  45              


Ser Ser Trp Phe Thr Ala Met Leu His Cys Phe Gly Gly Gly Ile Leu 
    50                  55                  60                  


Ser Cys Leu Leu Leu Ala Glu Pro Pro Leu Lys Phe Leu Ala Asn His 
65                  70                  75                  80  


Thr Asn Ile Leu Leu Ala Ser Ser Ile Trp Tyr Ile Thr Phe Phe Cys 
                85                  90                  95      


Pro His Asp Leu Val Ser Gln Gly Tyr Ser Tyr Leu Pro Val Gln Leu 
            100                 105                 110         


Leu Ala Ser Gly Met Lys Glu Val Thr Arg Thr Trp Lys Ile Val Gly 
        115                 120                 125             


Gly Val Thr His Ala Asn Ser Tyr Tyr Lys Asn Gly Trp Ile Val Met 
    130                 135                 140                 


Ile Ala Ile Gly Trp Ala Arg Gly Ala Gly Gly Thr Ile Ile Thr Asn 
145                 150                 155                 160 


Phe Glu Arg Leu Val Lys Gly Asp Trp Lys Pro Glu Gly Asp Glu Trp 
                165                 170                 175     


Leu Lys Met Ser Tyr Pro Ala Lys Val Thr Leu Leu Gly Ser Val Ile 
            180                 185                 190         


Phe Thr Phe Gln His Thr Gln His Leu Ala Ile Ser Lys His Asn Leu 
        195                 200                 205             


Met Phe Leu Tyr Thr Ile Phe Ile Val Ala Thr Lys Ile Thr Met Met 
    210                 215                 220                 


Thr Thr Gln Thr Ser Thr Met Thr Phe Ala Pro Phe Glu Asp Thr Leu 
225                 230                 235                 240 


Ser Trp Met Leu Phe Gly Trp Gln Gln Pro Phe Ser Ser Cys Glu Lys 
                245                 250                 255     


Lys Ser Glu Ala Lys Ser Pro Ser Asn Gly Val Gly Ser Leu Ala Ser 
            260                 265                 270         


Lys Pro Val Asp Val Ala Ser Asp Asn Val Lys Lys Lys His Thr Lys 
        275                 280                 285             


Lys Asn Glu 
    290     


<210>  4395
<211>  489
<212>  PRT
<213>  Homo sapiens

<400>  4395

Met Glu Ala Pro Asp Tyr Glu Val Leu Ser Val Arg Glu Gln Leu Phe 
1               5                   10                  15      


His Glu Arg Ile Arg Glu Cys Ile Ile Ser Thr Leu Leu Phe Ala Thr 
            20                  25                  30          


Leu Tyr Ile Leu Cys His Ile Phe Leu Thr Arg Phe Lys Lys Pro Ala 
        35                  40                  45              


Glu Phe Thr Thr Val Asp Asp Glu Asp Ala Thr Val Asn Lys Ile Ala 
    50                  55                  60                  


Leu Glu Leu Cys Thr Phe Thr Leu Ala Ile Ala Leu Gly Ala Val Leu 
65                  70                  75                  80  


Leu Leu Pro Phe Ser Ile Ile Ser Asn Glu Val Leu Leu Ser Leu Pro 
                85                  90                  95      


Arg Asn Tyr Tyr Ile Gln Trp Leu Asn Gly Ser Leu Ile His Gly Leu 
            100                 105                 110         


Trp Asn Leu Val Phe Leu Phe Ser Asn Leu Ser Leu Ile Phe Leu Met 
        115                 120                 125             


Pro Phe Ala Tyr Phe Phe Thr Glu Ser Glu Gly Phe Ala Gly Ser Arg 
    130                 135                 140                 


Lys Gly Val Leu Gly Arg Val Tyr Glu Thr Val Val Met Leu Met Leu 
145                 150                 155                 160 


Leu Thr Leu Leu Val Leu Gly Met Val Trp Val Ala Ser Ala Ile Val 
                165                 170                 175     


Asp Lys Asn Lys Ala Asn Arg Glu Ser Leu Tyr Asp Phe Trp Glu Tyr 
            180                 185                 190         


Tyr Leu Pro Tyr Leu Tyr Ser Cys Ile Ser Phe Leu Gly Val Leu Leu 
        195                 200                 205             


Leu Leu Val Cys Thr Pro Leu Gly Leu Ala Arg Met Phe Ser Val Thr 
    210                 215                 220                 


Gly Lys Leu Leu Val Lys Pro Arg Leu Leu Glu Asp Leu Glu Glu Gln 
225                 230                 235                 240 


Leu Tyr Cys Ser Ala Phe Glu Glu Ala Ala Leu Thr Arg Arg Ile Cys 
                245                 250                 255     


Asn Pro Thr Ser Cys Trp Leu Pro Leu Asp Met Glu Leu Leu His Arg 
            260                 265                 270         


Gln Val Leu Ala Leu Gln Thr Gln Arg Val Leu Leu Glu Lys Arg Arg 
        275                 280                 285             


Lys Ala Ser Ala Trp Gln Arg Asn Leu Gly Tyr Pro Leu Ala Met Leu 
    290                 295                 300                 


Cys Leu Leu Val Leu Thr Gly Leu Ser Val Leu Ile Val Ala Ile His 
305                 310                 315                 320 


Ile Leu Glu Leu Leu Ile Asp Glu Ala Ala Met Pro Arg Gly Met Gln 
                325                 330                 335     


Gly Thr Ser Leu Gly Gln Val Ser Phe Ser Lys Leu Gly Ser Phe Gly 
            340                 345                 350         


Ala Val Ile Gln Val Val Leu Ile Phe Tyr Leu Met Val Ser Ser Val 
        355                 360                 365             


Val Gly Phe Tyr Ser Ser Pro Leu Phe Arg Ser Leu Arg Pro Arg Trp 
    370                 375                 380                 


His Asp Thr Ala Met Thr Gln Ile Ile Gly Asn Cys Val Cys Leu Leu 
385                 390                 395                 400 


Val Leu Ser Ser Ala Leu Pro Val Phe Ser Arg Thr Leu Gly Leu Thr 
                405                 410                 415     


Arg Phe Asp Leu Leu Gly Asp Phe Gly Arg Phe Asn Trp Leu Gly Asn 
            420                 425                 430         


Phe Tyr Ile Val Phe Leu Tyr Asn Ala Ala Phe Ala Gly Leu Thr Thr 
        435                 440                 445             


Leu Cys Leu Val Lys Thr Phe Thr Ala Ala Val Arg Ala Glu Leu Ile 
    450                 455                 460                 


Arg Ala Phe Gly Leu Asp Arg Leu Pro Leu Pro Val Ser Gly Phe Pro 
465                 470                 475                 480 


Gln Ala Ser Arg Lys Thr Gln His Gln 
                485                 


<210>  4396
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  4396

Met Ala Asp Thr Thr Pro Asn Gly Pro Gln Gly Ala Gly Ala Val Gln 
1               5                   10                  15      


Phe Met Met Thr Asn Lys Leu Asp Thr Ala Met Trp Leu Ser Arg Leu 
            20                  25                  30          


Phe Thr Val Tyr Cys Ser Ala Leu Phe Val Leu Pro Leu Leu Gly Leu 
        35                  40                  45              


His Glu Ala Ala Ser Phe Tyr Gln Arg Ala Leu Leu Ala Asn Ala Leu 
    50                  55                  60                  


Thr Ser Ala Leu Arg Leu His Gln Arg Leu Pro His Phe Gln Leu Ser 
65                  70                  75                  80  


Arg Ala Phe Leu Ala Gln Ala Leu Leu Glu Asp Ser Cys His Tyr Leu 
                85                  90                  95      


Leu Tyr Ser Leu Ile Phe Val Asn Ser Tyr Pro Val Thr Met Ser Ile 
            100                 105                 110         


Phe Pro Val Leu Leu Phe Ser Leu Leu His Ala Ala Thr Tyr Thr Lys 
        115                 120                 125             


Lys Val Leu Asp Ala Arg Gly Ser Asn Ser Leu Pro Leu Leu Arg Ser 
    130                 135                 140                 


Val Leu Asp Lys Leu Ser Ala Asn Gln Gln Asn Ile Leu Lys Phe Ile 
145                 150                 155                 160 


Ala Cys Asn Glu Ile Phe Leu Met Pro Ala Thr Val Phe Met Leu Phe 
                165                 170                 175     


Ser Gly Gln Gly Ser Leu Leu Gln Pro Phe Ile Tyr Tyr Arg Phe Leu 
            180                 185                 190         


Thr Leu Arg Tyr Ser Ser Arg Arg Asn Pro Tyr Cys Arg Thr Leu Phe 
        195                 200                 205             


Asn Glu Leu Arg Ile Val Val Glu His Ile Ile Met Lys Pro Ala Cys 
    210                 215                 220                 


Pro Leu Phe Val Arg Arg Leu Cys Leu Gln Ser Ile Ala Phe Ile Ser 
225                 230                 235                 240 


Arg Leu Ala Pro Thr Val Pro 
                245         


<210>  4397
<211>  476
<212>  PRT
<213>  Homo sapiens

<400>  4397

Met Gly Ile Lys Phe Leu Glu Val Ile Lys Pro Phe Cys Ala Val Leu 
1               5                   10                  15      


Pro Glu Ile Gln Lys Pro Glu Arg Lys Ile Gln Phe Arg Glu Lys Val 
            20                  25                  30          


Leu Trp Thr Ala Ile Thr Leu Phe Ile Phe Leu Val Cys Cys Gln Ile 
        35                  40                  45              


Pro Leu Phe Gly Ile Met Ser Ser Asp Ser Ala Asp Pro Phe Tyr Trp 
    50                  55                  60                  


Met Arg Val Ile Leu Ala Ser Asn Arg Gly Thr Leu Met Glu Leu Gly 
65                  70                  75                  80  


Ile Ser Pro Ile Val Thr Ser Gly Leu Ile Met Gln Leu Leu Ala Gly 
                85                  90                  95      


Ala Lys Ile Ile Glu Val Gly Asp Thr Pro Lys Asp Arg Ala Leu Phe 
            100                 105                 110         


Asn Gly Ala Gln Lys Leu Phe Gly Met Ile Ile Thr Ile Gly Gln Ala 
        115                 120                 125             


Ile Val Tyr Val Met Thr Gly Met Tyr Gly Asp Pro Ala Glu Met Gly 
    130                 135                 140                 


Ala Gly Ile Cys Leu Leu Ile Ile Ile Gln Leu Phe Val Ala Gly Leu 
145                 150                 155                 160 


Ile Val Leu Leu Leu Asp Glu Leu Leu Gln Lys Gly Tyr Gly Leu Gly 
                165                 170                 175     


Ser Gly Ile Ser Leu Phe Ile Ala Thr Asn Ile Cys Glu Thr Ile Val 
            180                 185                 190         


Trp Lys Ala Phe Ser Pro Thr Thr Ile Asn Thr Gly Arg Gly Thr Glu 
        195                 200                 205             


Phe Glu Gly Ala Val Ile Ala Leu Phe His Leu Leu Ala Thr Arg Thr 
    210                 215                 220                 


Asp Lys Val Arg Ala Leu Arg Glu Ala Phe Tyr Arg Gln Asn Leu Pro 
225                 230                 235                 240 


Asn Leu Met Asn Leu Ile Ala Thr Val Phe Val Phe Ala Val Val Ile 
                245                 250                 255     


Tyr Phe Gln Gly Phe Arg Val Asp Leu Pro Ile Lys Ser Ala Arg Tyr 
            260                 265                 270         


Arg Gly Gln Tyr Ser Ser Tyr Pro Ile Lys Leu Phe Tyr Thr Ser Asn 
        275                 280                 285             


Ile Pro Ile Ile Leu Gln Ser Ala Leu Val Ser Asn Leu Tyr Val Ile 
    290                 295                 300                 


Ser Gln Met Leu Ser Val Arg Phe Ser Gly Asn Phe Leu Val Asn Leu 
305                 310                 315                 320 


Leu Gly Gln Trp Ala Asp Val Ser Gly Gly Gly Pro Ala Arg Ser Tyr 
                325                 330                 335     


Pro Val Gly Gly Leu Cys Tyr Tyr Leu Ser Pro Pro Glu Ser Met Gly 
            340                 345                 350         


Ala Ile Phe Glu Asp Pro Val His Val Val Val Tyr Ile Ile Phe Met 
        355                 360                 365             


Leu Gly Ser Cys Ala Phe Phe Ser Lys Thr Trp Ile Glu Val Ser Gly 
    370                 375                 380                 


Ser Ser Ala Lys Asp Val Ala Lys Gln Leu Lys Glu Gln Gln Met Val 
385                 390                 395                 400 


Met Arg Gly His Arg Asp Thr Ser Met Val His Glu Leu Asn Arg Tyr 
                405                 410                 415     


Ile Pro Thr Ala Ala Ala Phe Gly Gly Leu Cys Ile Gly Ala Leu Ser 
            420                 425                 430         


Val Leu Ala Asp Phe Leu Gly Ala Ile Gly Ser Gly Thr Gly Ile Leu 
        435                 440                 445             


Leu Ala Val Thr Ile Ile Tyr Gln Tyr Phe Glu Ile Phe Val Lys Glu 
    450                 455                 460                 


Gln Ala Glu Val Gly Gly Met Gly Ala Leu Phe Phe 
465                 470                 475     


<210>  4398
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  4398

Met Ser Arg Leu Gly Ala Leu Gly Gly Ala Arg Ala Gly Leu Gly Leu 
1               5                   10                  15      


Leu Leu Gly Thr Ala Ala Gly Leu Gly Phe Leu Cys Leu Leu Tyr Ser 
            20                  25                  30          


Gln Arg Trp Lys Arg Thr Gln Arg His Gly Arg Ser Gln Ser Leu Pro 
        35                  40                  45              


Asn Ser Leu Asp Tyr Thr Gln Thr Ser Asp Pro Gly Arg His Val Met 
    50                  55                  60                  


Leu Leu Arg Ala Val Pro Gly Gly Ala Gly Asp Ala Ser Val Leu Pro 
65                  70                  75                  80  


Ser Leu Pro Arg Glu Gly Gln Glu Lys Val Leu Asp Arg Leu Asp Phe 
                85                  90                  95      


Val Leu Thr Ser Leu Val Ala Leu Arg Arg Glu Val Glu Glu Leu Arg 
            100                 105                 110         


Ser Ser Leu Arg Gly Leu Ala Gly Glu Ile Val Gly Glu Val Arg Cys 
        115                 120                 125             


His Met Glu Glu Asn Gln Arg Val Ala Arg Arg Arg Arg Phe Pro Phe 
    130                 135                 140                 


Val Arg Glu Arg Ser Asp Ser Thr Gly Ser Ser Ser Val Tyr Phe Thr 
145                 150                 155                 160 


Ala Ser Ser Gly Ala Thr Phe Thr Asp Ala Glu Ser Glu Gly Gly Tyr 
                165                 170                 175     


Thr Thr Ala Asn Ala Glu Ser Asp Asn Glu Arg Asp Ser Asp Lys Glu 
            180                 185                 190         


Ser Glu Asp Gly Glu Asp Glu Val Ser Cys Glu Thr Val Lys Met Gly 
        195                 200                 205             


Arg Lys Asp Ser Leu Asp Leu Glu Glu Glu Ala Ala Ser Gly Ala Ser 
    210                 215                 220                 


Ser Ala Leu Glu Ala Gly Gly Ser Ser Gly Leu Glu Asp Val Leu Pro 
225                 230                 235                 240 


Leu Leu Gln Gln Ala Asp Glu Leu His Arg Gly Asp Glu Gln Gly Lys 
                245                 250                 255     


Arg Glu Gly Phe Gln Leu Leu Leu Asn Asn Lys Leu Val Tyr Gly Ser 
            260                 265                 270         


Arg Gln Asp Phe Leu Trp Arg Leu Ala Arg Ala Tyr Ser Asp Met Cys 
        275                 280                 285             


Glu Leu Thr Glu Glu Val Ser Glu Lys Lys Ser Tyr Ala Leu Asp Gly 
    290                 295                 300                 


Lys Glu Glu Ala Glu Ala Ala Leu Glu Lys Gly Asp Glu Ser Ala Asp 
305                 310                 315                 320 


Cys His Leu Trp Tyr Ala Val Leu Cys Gly Gln Leu Ala Glu His Glu 
                325                 330                 335     


Ser Ile Gln Arg Arg Ile Gln Ser Gly Phe Ser Phe Lys Glu His Val 
            340                 345                 350         


Asp Lys Ala Ile Ala Leu Gln Pro Glu Asn Pro Met Ala His Phe Leu 
        355                 360                 365             


Leu Gly Arg Trp Cys Tyr Gln Val Ser His Leu Ser Trp Leu Glu Lys 
    370                 375                 380                 


Lys Thr Ala Thr Ala Leu Leu Glu Ser Pro Leu Ser Ala Thr Val Glu 
385                 390                 395                 400 


Asp Ala Leu Gln Ser Phe Leu Lys Ala Glu Glu Leu Gln Pro Gly Phe 
                405                 410                 415     


Ser Lys Ala Gly Arg Val Tyr Ile Ser Lys Cys Tyr Arg Glu Leu Gly 
            420                 425                 430         


Lys Asn Ser Glu Ala Arg Trp Trp Met Lys Leu Ala Leu Glu Leu Pro 
        435                 440                 445             


Asp Val Thr Lys Glu Asp Leu Ala Ile Gln Lys Asp Leu Glu Glu Leu 
    450                 455                 460                 


Glu Val Ile Leu Arg Asp 
465                 470 


<210>  4399
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  4399

Met Ala Thr Ala Glu Arg Arg Ala Leu Gly Ile Gly Phe Gln Trp Leu 
1               5                   10                  15      


Ser Leu Ala Thr Leu Val Leu Ile Cys Ala Gly Gln Gly Gly Arg Arg 
            20                  25                  30          


Glu Asp Gly Gly Pro Ala Cys Tyr Gly Gly Phe Asp Leu Tyr Phe Ile 
        35                  40                  45              


Leu Asp Lys Ser Gly Ser Val Leu His His Trp Asn Glu Ile Tyr Tyr 
    50                  55                  60                  


Phe Val Glu Gln Leu Ala His Lys Phe Ile Ser Pro Gln Leu Arg Met 
65                  70                  75                  80  


Ser Phe Ile Val Phe Ser Thr Arg Gly Thr Thr Leu Met Lys Leu Thr 
                85                  90                  95      


Glu Asp Arg Glu Gln Ile Arg Gln Gly Leu Glu Glu Leu Gln Lys Val 
            100                 105                 110         


Leu Pro Gly Gly Asp Thr Tyr Met His Glu Gly Phe Glu Arg Ala Ser 
        115                 120                 125             


Glu Gln Ile Tyr Tyr Glu Asn Arg Gln Gly Tyr Arg Thr Ala Ser Val 
    130                 135                 140                 


Ile Ile Ala Leu Thr Asp Gly Glu Leu His Glu Asp Leu Phe Phe Tyr 
145                 150                 155                 160 


Ser Glu Arg Glu Ala Asn Arg Ser Arg Asp Leu Gly Ala Ile Val Tyr 
                165                 170                 175     


Cys Val Gly Val Lys Asp Phe Asn Glu Thr Gln Leu Ala Arg Ile Ala 
            180                 185                 190         


Asp Ser Lys Asp His Val Phe Pro Val Asn Asp Gly Phe Gln Ala Leu 
        195                 200                 205             


Gln Gly Ile Ile His Ser Ile Leu Lys Lys Ser Cys Ile Glu Ile Leu 
    210                 215                 220                 


Ala Ala Glu Pro Ser Thr Ile Cys Ala Gly Glu Ser Phe Gln Val Val 
225                 230                 235                 240 


Val Arg Gly Asn Gly Phe Arg His Ala Arg Asn Val Asp Arg Val Leu 
                245                 250                 255     


Cys Ser Phe Lys Ile Asn Asp Ser Val Thr Leu Asn Glu Lys Pro Phe 
            260                 265                 270         


Ser Val Glu Asp Thr Tyr Leu Leu Cys Pro Ala Pro Ile Leu Lys Glu 
        275                 280                 285             


Val Gly Met Lys Ala Ala Leu Gln Val Ser Met Asn Asp Gly Leu Ser 
    290                 295                 300                 


Phe Ile Ser Ser Ser Val Ile Ile Thr Thr Thr His Cys Ser Leu His 
305                 310                 315                 320 


Lys Ile Ala Ser Gly Pro Thr Thr Ala Ala Cys Met Glu 
                325                 330             


<210>  4400
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  4400

Met Asp Ala Pro Arg Arg Asp Met Glu Leu Leu Ser Asn Ser Leu Ala 
1               5                   10                  15      


Ala Tyr Ala His Ile Arg Ala Asn Pro Glu Ser Phe Gly Leu Tyr Phe 
            20                  25                  30          


Val Leu Gly Val Cys Phe Gly Leu Leu Leu Thr Leu Cys Leu Leu Val 
        35                  40                  45              


Ile Ser Ile Ser Trp Ala Pro Arg Pro Arg Pro Arg Gly Pro Ala Gln 
    50                  55                  60                  


Arg Arg Asp Pro Arg Ser Ser Thr Leu Glu Pro Glu Asp Asp Asp Glu 
65                  70                  75                  80  


Asp Glu Glu Asp Thr Val Thr Arg Leu Gly Pro Asp Asp Thr Leu Pro 
                85                  90                  95      


Gly Pro Glu Leu Ser Ala Glu Pro Asp Gly Pro Leu Asn Val Asn Val 
            100                 105                 110         


Phe Thr Ser Ala Glu Glu Leu Glu Arg Ala Gln Arg Leu Glu Glu Arg 
        115                 120                 125             


Glu Arg Ile Leu Arg Glu Ile Trp Arg Thr Gly Gln Pro Asp Leu Leu 
    130                 135                 140                 


Gly Thr Gly Thr Leu Gly Pro Ser Pro Thr Ala Thr Gly Thr Leu Gly 
145                 150                 155                 160 


Arg Met His Tyr Tyr 
                165 


<210>  4401
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  4401

Met Leu Pro Arg Trp Glu Leu Ala Leu Tyr Leu Leu Ala Ser Leu Gly 
1               5                   10                  15      


Phe His Phe Tyr Ser Phe Tyr Glu Val Tyr Lys Val Ser Arg Glu His 
            20                  25                  30          


Glu Glu Glu Leu Asp Gln Glu Phe Glu Leu Glu Thr Asp Thr Leu Phe 
        35                  40                  45              


Gly Gly Leu Lys Lys Asp Ala Thr Asp Phe Glu Trp Ser Phe Trp Met 
    50                  55                  60                  


Glu Trp Gly Lys Gln Trp Leu Val Trp Leu Leu Leu Gly His Met Val 
65                  70                  75                  80  


Val Ser Gln Met Ala Thr Leu Leu Ala Arg Lys His Arg Pro Trp Ile 
                85                  90                  95      


Leu Met Leu Tyr Gly Met Trp Ala Cys Trp Cys Val Leu Gly Thr Pro 
            100                 105                 110         


Gly Val Ala Met Val Leu Leu His Thr Thr Ile Ser Phe Cys Val Ala 
        115                 120                 125             


Gln Phe Arg Ser Gln Leu Leu Thr Trp Leu Cys Ser Leu Leu Leu Leu 
    130                 135                 140                 


Ser Thr Leu Arg Leu Gln Gly Val Glu Glu Val Lys Arg Arg Trp Tyr 
145                 150                 155                 160 


Lys Thr Glu Asn Glu Tyr Tyr Leu Leu Gln Phe Thr Leu Thr Val Arg 
                165                 170                 175     


Cys Leu Tyr Tyr Thr Ser Phe Ser Leu Glu Leu Cys Trp Gln Gln Leu 
            180                 185                 190         


Pro Ala Ala Ser Thr Ser Tyr Ser Phe Pro Trp Met Leu Ala Tyr Val 
        195                 200                 205             


Phe Tyr Tyr Pro Val Leu His Asn Gly Pro Ile Leu Ser Phe Ser Glu 
    210                 215                 220                 


Phe Ile Lys Gln Met Gln Gln Gln Glu His Asp Ser Leu Lys Ala Ser 
225                 230                 235                 240 


Leu Cys Val Leu Ala Leu Gly Leu Gly Arg Leu Leu Cys Trp Trp Trp 
                245                 250                 255     


Leu Ala Glu Leu Met Ala His Leu Met Tyr Met His Ala Ile Tyr Ser 
            260                 265                 270         


Ser Ile Pro Leu Leu Glu Thr Val Ser Cys Trp Thr Leu Gly Gly Leu 
        275                 280                 285             


Ala Leu Ala Gln Val Leu Phe Phe Tyr Val Lys Tyr Leu Val Leu Phe 
    290                 295                 300                 


Gly Val Pro Ala Leu Leu Met Arg Leu Asp Gly Leu Thr Pro Pro Ala 
305                 310                 315                 320 


Leu Pro Arg Cys Val Ser Thr Met Phe Ser Phe Thr Gly Met Trp Arg 
                325                 330                 335     


Tyr Phe Asp Val Gly Leu His Asn Phe Leu Ile Arg Tyr Val Tyr Ile 
            340                 345                 350         


Pro Val Gly Gly Ser Gln His Gly Leu Leu Gly Thr Leu Phe Ser Thr 
        355                 360                 365             


Ala Met Thr Phe Ala Phe Val Ser Tyr Trp His Gly Gly Tyr Asp Tyr 
    370                 375                 380                 


Leu Trp Cys Trp Ala Ala Leu Asn Trp Leu Gly Val Thr Val Glu Asn 
385                 390                 395                 400 


Gly Val Arg Arg Leu Val Glu Thr Pro Cys Ile Gln Asp Ser Leu Ala 
                405                 410                 415     


Arg Tyr Phe Ser Pro Gln Ala Arg Arg Arg Phe His Ala Ala Leu Ala 
            420                 425                 430         


Ser Cys Ser Thr Ser Met Leu Ile Leu Ser Asn Leu Val Phe Leu Gly 
        435                 440                 445             


Gly Asn Glu Val Gly Lys Thr Tyr Trp Asn Arg Ile Phe Ile Gln Gly 
    450                 455                 460                 


Trp Pro Trp Val Thr Leu Ser Val Leu Gly Phe Leu Tyr Cys Tyr Ser 
465                 470                 475                 480 


His Val Gly Ile Ala Trp Ala Gln Thr Tyr Ala Thr Asp 
                485                 490             


<210>  4402
<211>  664
<212>  PRT
<213>  Homo sapiens

<400>  4402

Met Lys Arg Arg Asn Ala Asp Cys Ser Lys Leu Arg Arg Pro Leu Lys 
1               5                   10                  15      


Arg Asn Arg Ile Thr Glu Gly Ile Tyr Gly Ser Thr Phe Leu Tyr Leu 
            20                  25                  30          


Lys Phe Leu Val Val Trp Ala Leu Val Leu Leu Ala Asp Phe Val Leu 
        35                  40                  45              


Glu Phe Arg Phe Glu Tyr Leu Trp Pro Phe Trp Leu Phe Ile Arg Ser 
    50                  55                  60                  


Val Tyr Asp Ser Phe Arg Tyr Gln Gly Leu Ala Phe Ser Val Phe Phe 
65                  70                  75                  80  


Val Cys Val Ala Phe Thr Ser Asn Ile Ile Cys Leu Leu Phe Ile Pro 
                85                  90                  95      


Ile Gln Trp Leu Phe Phe Ala Ala Ser Thr Tyr Val Trp Val Gln Tyr 
            100                 105                 110         


Val Trp His Thr Glu Arg Gly Val Cys Leu Pro Thr Val Ser Leu Trp 
        115                 120                 125             


Ile Leu Phe Val Tyr Ile Glu Ala Ala Ile Arg Phe Lys Asp Leu Lys 
    130                 135                 140                 


Asn Phe His Val Asp Leu Cys Arg Pro Phe Ala Ala His Cys Ile Gly 
145                 150                 155                 160 


Tyr Pro Val Val Thr Leu Gly Phe Gly Phe Lys Ser Tyr Val Ser Tyr 
                165                 170                 175     


Lys Met Arg Leu Arg Lys Gln Lys Glu Val Gln Lys Glu Asn Glu Phe 
            180                 185                 190         


Tyr Met Gln Leu Leu Gln Gln Ala Leu Pro Pro Glu Gln Gln Met Leu 
        195                 200                 205             


Gln Lys Gln Glu Lys Glu Ala Glu Glu Ala Ala Lys Gly Leu Pro Asp 
    210                 215                 220                 


Met Asp Ser Ser Ile Leu Ile His His Asn Gly Gly Ile Pro Ala Asn 
225                 230                 235                 240 


Lys Lys Leu Ser Thr Thr Leu Pro Glu Ile Glu Tyr Arg Glu Lys Gly 
                245                 250                 255     


Lys Glu Lys Asp Lys Asp Ala Lys Lys His Asn Leu Gly Ile Asn Asn 
            260                 265                 270         


Asn Asn Ile Leu Gln Pro Val Asp Ser Lys Ile Gln Glu Ile Glu Tyr 
        275                 280                 285             


Met Glu Asn His Ile Asn Ser Lys Arg Leu Asn Asn Asp Leu Val Gly 
    290                 295                 300                 


Ser Thr Glu Asn Leu Leu Lys Glu Asp Ser Cys Thr Ala Ser Ser Lys 
305                 310                 315                 320 


Asn Tyr Lys Asn Ala Ser Gly Val Val Asn Ser Ser Pro Arg Ser His 
                325                 330                 335     


Ser Ala Thr Asn Gly Ser Ile Pro Ser Ser Ser Ser Lys Asn Glu Lys 
            340                 345                 350         


Lys Gln Lys Cys Thr Ser Lys Ser Pro Ser Thr His Lys Asp Leu Met 
        355                 360                 365             


Glu Asn Cys Ile Pro Asn Asn Gln Leu Ser Lys Pro Asp Ala Leu Val 
    370                 375                 380                 


Arg Leu Glu Gln Asp Ile Lys Lys Leu Lys Ala Asp Leu Gln Ala Ser 
385                 390                 395                 400 


Arg Gln Val Glu Gln Glu Leu Arg Ser Gln Ile Ser Ser Leu Ser Ser 
                405                 410                 415     


Thr Glu Arg Gly Ile Arg Ser Glu Met Gly Gln Leu Arg Gln Glu Asn 
            420                 425                 430         


Glu Leu Leu Gln Asn Lys Leu His Asn Ala Val Gln Met Lys Gln Lys 
        435                 440                 445             


Asp Lys Gln Asn Ile Ser Gln Leu Glu Lys Lys Leu Lys Ala Glu Gln 
    450                 455                 460                 


Glu Ala Arg Ser Phe Val Glu Lys Gln Leu Met Glu Glu Lys Lys Arg 
465                 470                 475                 480 


Lys Lys Leu Glu Glu Ala Thr Ala Ala Arg Ala Val Ala Phe Ala Ala 
                485                 490                 495     


Ala Ser Arg Gly Glu Cys Thr Glu Thr Leu Arg Asn Arg Ile Arg Glu 
            500                 505                 510         


Leu Glu Ala Glu Gly Lys Lys Leu Thr Met Asp Met Lys Val Lys Glu 
        515                 520                 525             


Asp Gln Ile Arg Glu Leu Glu Leu Lys Val Gln Glu Leu Arg Lys Tyr 
    530                 535                 540                 


Lys Glu Asn Glu Lys Asp Thr Glu Val Leu Met Ser Ala Leu Ser Ala 
545                 550                 555                 560 


Met Gln Asp Lys Thr Gln His Leu Glu Asn Ser Leu Ser Ala Glu Thr 
                565                 570                 575     


Arg Ile Lys Leu Asp Leu Phe Ser Ala Leu Gly Asp Ala Lys Arg Gln 
            580                 585                 590         


Leu Glu Ile Ala Gln Gly Gln Ile Leu Gln Lys Asp Gln Glu Ile Lys 
        595                 600                 605             


Asp Leu Lys Gln Lys Ile Ala Glu Val Met Ala Val Met Pro Ser Ile 
    610                 615                 620                 


Thr Tyr Ser Ala Ala Thr Ser Pro Leu Ser Pro Val Ser Pro His Tyr 
625                 630                 635                 640 


Ser Ser Lys Phe Val Glu Thr Ser Pro Ser Gly Leu Asp Pro Asn Ala 
                645                 650                 655     


Ser Val Tyr Gln Pro Leu Lys Lys 
            660                 


<210>  4403
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  4403

Met Val Thr Arg Ala Gly Ala Gly Thr Ala Val Ala Gly Ala Val Val 
1               5                   10                  15      


Val Ala Leu Leu Ser Ala Ala Leu Ala Leu Tyr Gly Pro Pro Leu Asp 
            20                  25                  30          


Ala Val Leu Glu Arg Ala Phe Ser Leu Arg Lys Ala His Ser Ile Lys 
        35                  40                  45              


Asp Met Glu Asn Thr Leu Gln Leu Val Arg Asn Ile Ile Pro Pro Leu 
    50                  55                  60                  


Ser Ser Thr Lys His Lys Gly Gln Asp Gly Arg Ile Gly Val Val Gly 
65                  70                  75                  80  


Gly Cys Gln Glu Tyr Thr Gly Ala Pro Tyr Phe Ala Ala Ile Ser Ala 
                85                  90                  95      


Leu Lys Val Gly Ala Asp Leu Ser His Val Phe Cys Ala Ser Ala Ala 
            100                 105                 110         


Ala Pro Val Ile Lys Ala Tyr Ser Pro Glu Leu Ile Val His Pro Val 
        115                 120                 125             


Leu Asp Ser Pro Asn Ala Val His Glu Val Glu Lys Trp Leu Pro Arg 
    130                 135                 140                 


Leu His Ala Leu Val Val Gly Pro Gly Leu Gly Arg Asp Asp Ala Leu 
145                 150                 155                 160 


Leu Arg Asn Val Gln Gly Ile Leu Glu Val Ser Lys Ala Arg Asp Ile 
                165                 170                 175     


Pro Val Val Ile Asp Ala Asp Gly Leu Trp Leu Val Ala Gln Gln Pro 
            180                 185                 190         


Ala Leu Ile His Gly Tyr Arg Lys Ala Val Leu Thr Pro Asn His Val 
        195                 200                 205             


Glu Phe Ser Arg Leu Tyr Asp Ala Val Leu Arg Gly Pro Met Asp Ser 
    210                 215                 220                 


Asp Asp Ser His Gly Ser Val Leu Arg Leu Ser Gln Ala Leu Gly Asn 
225                 230                 235                 240 


Val Thr Val Val Gln Lys Gly Glu Arg Asp Ile Leu Ser Asn Gly Gln 
                245                 250                 255     


Gln Val Leu Val Cys Ser Gln Glu Gly Ser Ser Arg Arg Cys Gly Gly 
            260                 265                 270         


Gln Gly Asp Leu Leu Ser Gly Ser Leu Gly Val Leu Val His Trp Ala 
        275                 280                 285             


Leu Leu Ala Gly Pro Gln Lys Thr Asn Gly Gly Ile Ser Asp Leu Lys 
    290                 295                 300                 


Leu Thr Ile Trp Gly Pro Glu Ile Glu Thr Gly Val Lys Thr Arg Ala 
305                 310                 315                 320 


Gln Gly Ser Cys Gly Pro Arg Thr Thr Thr Pro Thr Ser Pro His Leu 
                325                 330                 335     


Leu Leu Ser Pro Ser Pro Gln Val Gln Pro Ser Pro Gly Gly Arg Val 
            340                 345                 350         


Trp Arg Leu Leu Ser His Gln Ala Val Gln Pro Pro Ser Leu Pro Glu 
        355                 360                 365             


Ala Arg Ser Leu His His His Leu Arg His Asp Arg Arg Gly Gly Gly 
    370                 375                 380                 


Arg Leu Gln Gln Ala Leu 
385                 390 


<210>  4404
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  4404

Met Met Trp Gln Lys Tyr Ala Gly Ser Arg Arg Ser Met Pro Leu Gly 
1               5                   10                  15      


Ala Arg Ile Leu Phe His Gly Val Phe Tyr Ala Gly Gly Phe Ala Ile 
            20                  25                  30          


Val Tyr Tyr Leu Ile Gln Lys Phe His Ser Arg Ala Leu Tyr Tyr Lys 
        35                  40                  45              


Leu Ala Val Glu Gln Leu Gln Ser His Pro Glu Ala Gln Glu Ala Leu 
    50                  55                  60                  


Gly Pro Pro Leu Asn Ile His Tyr Leu Lys Leu Ile Asp Arg Glu Asn 
65                  70                  75                  80  


Phe Val Asp Ile Val Asp Ala Lys Leu Lys Ile Pro Val Ser Gly Ser 
                85                  90                  95      


Lys Ser Glu Gly Leu Leu Tyr Val His Ser Ser Arg Gly Gly Pro Phe 
            100                 105                 110         


Gln Arg Trp His Leu Asp Glu Val Phe Leu Glu Leu Lys Asp Gly Gln 
        115                 120                 125             


Gln Ile Pro Val Phe Lys Leu Ser Gly Glu Asn Gly Asp Glu Val Lys 
    130                 135                 140                 


Lys Glu 
145     


<210>  4405
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  4405

Met Ala Gln Val Ser Ile Asn Asn Asp Tyr Ser Glu Trp Asp Leu Ser 
1               5                   10                  15      


Thr Asp Ala Gly Glu Arg Ala Arg Leu Leu Gln Ser Pro Cys Val Asp 
            20                  25                  30          


Thr Ala Pro Lys Ser Glu Trp Glu Ala Ser Pro Gly Gly Leu Asp Arg 
        35                  40                  45              


Gly Thr Thr Ser Thr Leu Gly Ala Ile Phe Ile Val Val Asn Ala Cys 
    50                  55                  60                  


Leu Gly Ala Gly Leu Leu Asn Phe Pro Ala Ala Phe Ser Thr Ala Gly 
65                  70                  75                  80  


Gly Val Ala Ala Gly Ile Ala Leu Gln Met Gly Met Leu Val Phe Ile 
                85                  90                  95      


Ile Ser Gly Leu Val Ile Leu Ala Tyr Cys Ser Gln Ala Ser Asn Glu 
            100                 105                 110         


Arg Thr Tyr Gln Glu Val Val Trp Ala Val Cys Gly Lys Leu Thr Gly 
        115                 120                 125             


Val Leu Cys Glu Val Ala Ile Ala Val Tyr Thr Phe Gly Thr Cys Ile 
    130                 135                 140                 


Ala Phe Leu Ile Ile Ile Gly Asp Gln Gln Asp Lys Ile Ile Ala Val 
145                 150                 155                 160 


Met Ala Lys Glu Pro Glu Gly Ala Ser Gly Pro Trp Tyr Thr Asp Arg 
                165                 170                 175     


Lys Phe Thr Ile Ser Leu Thr Ala Phe Leu Phe Ile Leu Pro Leu Ser 
            180                 185                 190         


Ile Pro Arg Glu Ile Gly Phe Gln Lys Tyr Ala Ser Phe Leu Ser Val 
        195                 200                 205             


Val Gly Thr Trp Tyr Val Thr Ala Ile Val Ile Ile Lys Tyr Ile Trp 
    210                 215                 220                 


Pro Asp Lys Glu Met Thr Pro Gly Asn Ile Leu Thr Arg Pro Ala Ser 
225                 230                 235                 240 


Trp Met Ala Val Phe Asn Ala Met Pro Thr Ile Cys Phe Gly Phe Gln 
                245                 250                 255     


Cys His Val Ser Ser Val Pro Val Phe Asn Ser Met Gln Gln Pro Glu 
            260                 265                 270         


Val Lys Thr Trp Gly Gly Val Val Thr Ala Ala Met Val Ile Ala Leu 
        275                 280                 285             


Ala Val Tyr Met Gly Thr Gly Ile Cys Gly Phe Leu Thr Phe Gly Ala 
    290                 295                 300                 


Ala Val Asp Pro Asp Val Leu Leu Ser Tyr Pro Ser Glu Asp Met Ala 
305                 310                 315                 320 


Val Ala Val Ala Arg Ala Phe Ile Ile Leu Ser Val Leu Thr Ser Tyr 
                325                 330                 335     


Pro Ile Leu His Phe Cys Gly Arg Ala Val Val Glu Gly Leu Trp Leu 
            340                 345                 350         


Arg Tyr Gln Gly Val Pro Val Glu Glu Asp Val Gly Arg Glu Arg Arg 
        355                 360                 365             


Arg Arg Val Leu Gln Thr Leu Val Trp Phe Leu Leu Thr Leu Leu Leu 
    370                 375                 380                 


Ala Leu Phe Ile Pro Asp Ile Gly Lys Val Ile Ser Val Ile Gly Gly 
385                 390                 395                 400 


Leu Ala Ala Cys Phe Ile Phe Val Phe Pro Gly Leu Cys Leu Ile Gln 
                405                 410                 415     


Ala Lys Leu Ser Glu Met Glu Glu Val Lys Pro Ala Ser Trp Trp Val 
            420                 425                 430         


Leu Val Ser Tyr Gly Val Leu Leu Val Thr Leu Gly Ala Phe Ile Phe 
        435                 440                 445             


Gly Gln Thr Thr Ala Asn Ala Ile Phe Val Asp Leu Leu Ala 
    450                 455                 460         


<210>  4406
<211>  757
<212>  PRT
<213>  Homo sapiens

<400>  4406

Met Leu Ser Leu Leu Val Trp Ile Leu Thr Leu Ser Asp Thr Phe Ser 
1               5                   10                  15      


Gln Gly Thr Gln Thr Arg Phe Ser Gln Glu Pro Ala Asp Gln Thr Val 
            20                  25                  30          


Val Ala Gly Gln Arg Ala Val Leu Pro Cys Val Leu Leu Asn Tyr Ser 
        35                  40                  45              


Gly Ile Val Gln Trp Thr Lys Asp Gly Leu Ala Leu Gly Met Gly Gln 
    50                  55                  60                  


Gly Leu Lys Ala Trp Pro Arg Tyr Arg Val Val Gly Ser Ala Asp Ala 
65                  70                  75                  80  


Gly Gln Tyr Asn Leu Glu Ile Thr Asp Ala Glu Leu Ser Asp Asp Ala 
                85                  90                  95      


Ser Tyr Glu Cys Gln Ala Thr Glu Ala Ala Leu Arg Ser Arg Arg Ala 
            100                 105                 110         


Lys Leu Thr Val Leu Ile Pro Pro Glu Asp Thr Arg Ile Asp Gly Gly 
        115                 120                 125             


Pro Val Ile Leu Leu Gln Ala Gly Thr Pro His Asn Leu Thr Cys Arg 
    130                 135                 140                 


Ala Phe Asn Ala Lys Pro Ala Ala Thr Ile Ile Trp Phe Arg Asp Gly 
145                 150                 155                 160 


Thr Gln Gln Glu Gly Ala Val Ala Ser Thr Glu Leu Leu Lys Asp Gly 
                165                 170                 175     


Lys Arg Glu Thr Thr Val Ser Gln Leu Leu Ile Asn Pro Thr Asp Leu 
            180                 185                 190         


Asp Ile Gly Arg Val Phe Thr Cys Arg Ser Met Asn Glu Ala Ile Pro 
        195                 200                 205             


Ser Gly Lys Glu Thr Ser Ile Glu Leu Asp Val His His Pro Pro Thr 
    210                 215                 220                 


Val Thr Leu Ser Ile Glu Pro Gln Thr Val Gln Glu Gly Glu Arg Val 
225                 230                 235                 240 


Val Phe Thr Cys Gln Ala Thr Ala Asn Pro Glu Ile Leu Gly Tyr Arg 
                245                 250                 255     


Trp Ala Lys Gly Gly Phe Leu Ile Glu Asp Ala His Glu Ser Arg Tyr 
            260                 265                 270         


Glu Thr Asn Val Asp Tyr Ser Phe Phe Thr Glu Pro Val Ser Cys Glu 
        275                 280                 285             


Val His Asn Lys Val Gly Ser Thr Asn Val Ser Thr Leu Val Asn Val 
    290                 295                 300                 


His Phe Ala Pro Arg Ile Val Val Asp Pro Lys Pro Thr Thr Thr Asp 
305                 310                 315                 320 


Ile Gly Ser Asp Val Thr Leu Thr Cys Val Trp Val Gly Asn Pro Pro 
                325                 330                 335     


Leu Thr Leu Thr Trp Thr Lys Lys Asp Ser Asn Met Val Leu Ser Asn 
            340                 345                 350         


Ser Asn Gln Leu Leu Leu Lys Ser Val Thr Gln Ala Asp Ala Gly Thr 
        355                 360                 365             


Tyr Thr Cys Arg Ala Ile Val Pro Arg Ile Gly Val Ala Glu Arg Glu 
    370                 375                 380                 


Val Pro Leu Tyr Val Asn Gly Pro Pro Ile Ile Ser Ser Glu Ala Val 
385                 390                 395                 400 


Gln Tyr Ala Val Arg Gly Asp Gly Gly Lys Val Glu Cys Phe Ile Gly 
                405                 410                 415     


Ser Thr Pro Pro Pro Asp Arg Ile Ala Trp Ala Trp Lys Glu Asn Phe 
            420                 425                 430         


Leu Glu Val Gly Thr Leu Glu Arg Tyr Thr Val Glu Arg Thr Asn Ser 
        435                 440                 445             


Gly Ser Gly Val Leu Ser Thr Leu Thr Ile Asn Asn Val Met Glu Ala 
    450                 455                 460                 


Asp Phe Gln Thr His Tyr Asn Cys Thr Ala Trp Asn Ser Phe Gly Pro 
465                 470                 475                 480 


Gly Thr Ala Ile Ile Gln Leu Glu Glu Arg Glu Val Leu Pro Val Gly 
                485                 490                 495     


Ile Ile Ala Gly Ala Thr Ile Gly Ala Ser Ile Leu Leu Ile Phe Phe 
            500                 505                 510         


Phe Ile Ala Leu Val Phe Phe Leu Tyr Arg Arg Arg Lys Gly Ser Arg 
        515                 520                 525             


Lys Asp Val Thr Leu Arg Lys Leu Asp Ile Lys Val Glu Thr Val Asn 
    530                 535                 540                 


Arg Glu Pro Leu Thr Met His Ser Asp Arg Glu Asp Asp Thr Ala Ser 
545                 550                 555                 560 


Val Ser Thr Ala Thr Arg Val Met Lys Ala Ile Tyr Ser Ser Phe Lys 
                565                 570                 575     


Asp Asp Val Asp Leu Lys Gln Asp Leu Arg Cys Asp Thr Ile Asp Thr 
            580                 585                 590         


Arg Glu Glu Tyr Glu Met Lys Asp Pro Thr Asn Gly Tyr Tyr Asn Val 
        595                 600                 605             


Arg Ala His Glu Asp Arg Pro Ser Ser Arg Ala Val Leu Tyr Ala Asp 
    610                 615                 620                 


Tyr Arg Ala Pro Gly Pro Ala Arg Phe Asp Gly Arg Pro Ser Ser Arg 
625                 630                 635                 640 


Leu Ser His Ser Ser Gly Tyr Ala Gln Leu Asn Thr Tyr Ser Arg Gly 
                645                 650                 655     


Pro Ala Ser Asp Tyr Gly Pro Glu Pro Thr Pro Pro Gly Pro Ala Ala 
            660                 665                 670         


Pro Ala Gly Thr Asp Thr Thr Ser Gln Leu Ser Tyr Glu Asn Tyr Glu 
        675                 680                 685             


Lys Phe Asn Ser His Pro Phe Pro Gly Ala Ala Gly Tyr Pro Thr Tyr 
    690                 695                 700                 


Arg Leu Gly Tyr Pro Gln Ala Pro Pro Ser Gly Leu Glu Arg Thr Pro 
705                 710                 715                 720 


Tyr Glu Ala Tyr Asp Pro Ile Gly Lys Tyr Ala Thr Ala Thr Arg Phe 
                725                 730                 735     


Ser Tyr Thr Ser Gln His Ser Asp Tyr Gly Gln Arg Phe Gln Gln Arg 
            740                 745                 750         


Met Gln Thr His Val 
        755         


<210>  4407
<211>  570
<212>  PRT
<213>  Homo sapiens

<400>  4407

Met Glu Ala Pro Glu Glu Pro Ala Pro Val Arg Gly Gly Pro Glu Ala 
1               5                   10                  15      


Thr Leu Glu Val Arg Gly Ser Arg Cys Leu Arg Leu Ser Ala Phe Arg 
            20                  25                  30          


Glu Glu Leu Arg Ala Leu Leu Val Leu Ala Gly Pro Ala Phe Leu Val 
        35                  40                  45              


Gln Leu Met Val Phe Leu Ile Ser Phe Ile Ser Ser Val Phe Cys Gly 
    50                  55                  60                  


His Leu Gly Lys Leu Glu Leu Asp Ala Val Thr Leu Ala Ile Ala Val 
65                  70                  75                  80  


Ile Asn Val Thr Gly Val Ser Val Gly Phe Gly Leu Ser Ser Ala Cys 
                85                  90                  95      


Asp Thr Leu Ile Ser Gln Thr Tyr Gly Ser Gln Asn Leu Lys His Val 
            100                 105                 110         


Gly Val Ile Leu Gln Arg Ser Ala Leu Val Leu Leu Leu Cys Cys Phe 
        115                 120                 125             


Pro Cys Trp Ala Leu Phe Leu Asn Thr Gln His Ile Leu Leu Leu Phe 
    130                 135                 140                 


Arg Gln Asp Pro Asp Val Ser Arg Leu Thr Gln Thr Tyr Val Thr Ile 
145                 150                 155                 160 


Phe Ile Pro Ala Leu Pro Ala Thr Phe Leu Tyr Met Leu Gln Val Lys 
                165                 170                 175     


Tyr Leu Leu Asn Gln Gly Ile Val Leu Pro Gln Ile Val Thr Gly Val 
            180                 185                 190         


Ala Ala Asn Leu Val Asn Ala Leu Ala Asn Tyr Leu Phe Leu His Gln 
        195                 200                 205             


Leu His Leu Gly Val Ile Gly Ser Ala Leu Ala Asn Leu Ile Ser Gln 
    210                 215                 220                 


Tyr Thr Leu Ala Leu Leu Leu Phe Leu Tyr Ile Leu Gly Lys Lys Leu 
225                 230                 235                 240 


His Gln Ala Thr Trp Gly Gly Trp Ser Leu Glu Cys Leu Gln Asp Trp 
                245                 250                 255     


Ala Ser Phe Leu Arg Leu Ala Ile Pro Ser Met Leu Met Leu Cys Met 
            260                 265                 270         


Glu Trp Trp Ala Tyr Glu Val Gly Ser Phe Leu Ser Gly Ile Leu Gly 
        275                 280                 285             


Met Val Glu Leu Gly Ala Gln Ser Ile Val Tyr Glu Leu Ala Ile Ile 
    290                 295                 300                 


Val Tyr Met Val Pro Ala Gly Phe Ser Val Ala Ala Ser Val Arg Val 
305                 310                 315                 320 


Gly Asn Ala Leu Gly Ala Gly Asp Met Glu Gln Ala Arg Lys Ser Ser 
                325                 330                 335     


Thr Val Ser Leu Leu Ile Thr Val Leu Phe Ala Val Ala Phe Ser Val 
            340                 345                 350         


Leu Leu Leu Ser Cys Lys Asp His Val Gly Tyr Ile Phe Thr Thr Asp 
        355                 360                 365             


Arg Asp Ile Ile Asn Leu Val Ala Gln Val Val Pro Ile Tyr Ala Val 
    370                 375                 380                 


Ser His Leu Phe Glu Ala Leu Ala Cys Thr Ser Gly Gly Val Leu Arg 
385                 390                 395                 400 


Gly Ser Gly Asn Gln Lys Val Gly Ala Ile Val Asn Thr Ile Gly Tyr 
                405                 410                 415     


Tyr Val Val Gly Leu Pro Ile Gly Ile Ala Leu Met Phe Ala Thr Thr 
            420                 425                 430         


Leu Gly Val Met Gly Leu Trp Ser Gly Ile Ile Ile Cys Thr Val Phe 
        435                 440                 445             


Gln Ala Val Cys Phe Leu Gly Phe Ile Ile Gln Leu Asn Trp Lys Lys 
    450                 455                 460                 


Ala Cys Gln Gln Ala Gln Val His Ala Asn Leu Lys Val Asn Asn Val 
465                 470                 475                 480 


Pro Arg Ser Gly Asn Ser Ala Leu Pro Gln Asp Pro Leu His Pro Gly 
                485                 490                 495     


Cys Pro Glu Asn Leu Glu Gly Ile Leu Thr Asn Asp Val Gly Lys Thr 
            500                 505                 510         


Gly Glu Pro Gln Ser Asp Gln Gln Met Arg Gln Glu Glu Pro Leu Pro 
        515                 520                 525             


Glu His Pro Gln Asp Gly Ala Lys Leu Ser Arg Lys Gln Leu Val Leu 
    530                 535                 540                 


Arg Arg Gly Leu Leu Leu Leu Gly Val Phe Leu Ile Leu Leu Val Gly 
545                 550                 555                 560 


Ile Leu Val Arg Phe Tyr Val Arg Ile Gln 
                565                 570 


<210>  4408
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  4408

Met Ala Met Asn Tyr Asn Ala Lys Asp Glu Val Asp Gly Gly Pro Pro 
1               5                   10                  15      


Cys Ala Pro Gly Gly Thr Ala Lys Thr Arg Arg Pro Asp Asn Thr Ala 
            20                  25                  30          


Phe Lys Gln Gln Arg Leu Pro Ala Trp Gln Pro Ile Leu Thr Ala Gly 
        35                  40                  45              


Thr Val Leu Pro Ile Phe Phe Ile Ile Gly Leu Ile Phe Ile Pro Ile 
    50                  55                  60                  


Gly Ile Gly Ile Phe Val Thr Ser Asn Asn Ile Arg Glu Ile Glu Ile 
65                  70                  75                  80  


Asp Tyr Thr Gly Thr Glu Pro Ser Ser Pro Cys Asn Lys Cys Leu Ser 
                85                  90                  95      


Pro Asp Val Thr Pro Cys Phe Cys Thr Ile Asn Phe Thr Leu Glu Lys 
            100                 105                 110         


Ser Phe Glu Gly Asn Val Phe Met Tyr Tyr Gly Leu Ser Asn Phe Tyr 
        115                 120                 125             


Gln Asn His Arg Arg Tyr Val Lys Ser Arg Asp Asp Ser Gln Leu Asn 
    130                 135                 140                 


Gly Asp Ser Ser Ala Leu Leu Asn Pro Ser Lys Glu Cys Glu Pro Tyr 
145                 150                 155                 160 


Arg Arg Asn Glu Asp Lys Pro Ile Ala Pro Cys Gly Ala Ile Ala Asn 
                165                 170                 175     


Ser Met Phe Asn Asp Thr Leu Glu Leu Phe Leu Ile Gly Asn Asp Ser 
            180                 185                 190         


Tyr Pro Ile Pro Ile Ala Leu Lys Lys Lys Gly Ile Ala Trp Trp Thr 
        195                 200                 205             


Asp Lys Asn Val Lys Phe Arg Asn Pro Pro Gly Gly Asp Asn Leu Glu 
    210                 215                 220                 


Glu Arg Phe Lys Gly Thr Thr Lys Pro Val Asn Trp Leu Lys Pro Val 
225                 230                 235                 240 


Tyr Met Leu Asp Ser Asp Pro Asp Asn Asn Gly Phe Ile Asn Glu Asp 
                245                 250                 255     


Phe Ile Val Trp Met Arg Thr Ala Ala Leu Pro Thr Phe Arg Lys Leu 
            260                 265                 270         


Tyr Arg Leu Ile Glu Arg Lys Ser Asp Leu His Pro Thr Leu Pro Ala 
        275                 280                 285             


Gly Arg Tyr Ser Leu Asn Val Thr Tyr Asn Tyr Pro Val His Tyr Phe 
    290                 295                 300                 


Asp Gly Arg Lys Arg Met Ile Leu Ser Thr Ile Ser Trp Met Gly Gly 
305                 310                 315                 320 


Lys Asn Pro Phe Leu Gly Ile Ala Tyr Ile Ala Val Gly Ser Ile Ser 
                325                 330                 335     


Phe Leu Leu Gly Val Val Leu Leu Val Ile Asn His Lys Tyr Arg Asn 
            340                 345                 350         


Ser Ser Asn Thr Ala Asp Ile Thr Ile 
        355                 360     


<210>  4409
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  4409

Met Ile Arg Gln Glu Arg Ser Thr Ser Tyr Gln Glu Leu Ser Glu Glu 
1               5                   10                  15      


Leu Val Gln Val Val Glu Asn Ser Glu Leu Ala Asp Glu Gln Asp Lys 
            20                  25                  30          


Glu Thr Val Arg Val Gln Gly Pro Gly Ile Leu Pro Gly Leu Asp Ser 
        35                  40                  45              


Glu Ser Ala Ser Ser Ser Ile Arg Phe Ser Lys Ala Cys Leu Lys Asn 
    50                  55                  60                  


Val Phe Ser Val Leu Leu Ile Phe Ile Tyr Leu Leu Leu Met Ala Val 
65                  70                  75                  80  


Ala Val Phe Leu Val Tyr Arg Thr Ile Thr Asp Phe Arg Glu Lys Leu 
                85                  90                  95      


Lys His Pro Val Met Ser Val Ser Tyr Lys Glu Val Asp Arg Tyr Asp 
            100                 105                 110         


Ala Pro Gly Ile Ala Leu Tyr Pro Gly Gln Ala Gln Leu Leu Ser Cys 
        115                 120                 125             


Lys His His Tyr Glu Val Ile Pro Pro Leu Thr Ser Pro Gly Gln Pro 
    130                 135                 140                 


Gly Asp Met Asn Cys Thr Thr Gln Arg Ile Asn Tyr Thr Asp Pro Phe 
145                 150                 155                 160 


Ser Asn Gln Thr Val Lys Ser Ala Leu Ile Val Gln Gly Pro Arg Glu 
                165                 170                 175     


Val Lys Lys Arg Glu Leu Val Phe Leu Gln Phe Arg Leu Asn Lys Ser 
            180                 185                 190         


Ser Glu Asp Phe Ser Ala Ile Asp Tyr Leu Leu Phe Ser Ser Phe Gln 
        195                 200                 205             


Glu Phe Leu Gln Ser Pro Asn Arg Val Gly Phe Met Gln Ala Cys Glu 
    210                 215                 220                 


Ser Ala Tyr Ser Ser Trp Lys Phe Ser Gly Gly Phe Arg Thr Trp Val 
225                 230                 235                 240 


Lys Met Ser Leu Val Lys Thr Lys Glu Glu Asp Gly Arg Glu Ala Val 
                245                 250                 255     


Glu Phe Arg Gln Glu Thr Ser Val Val Asn Tyr Ile Asp Gln Arg Pro 
            260                 265                 270         


Ala Ala Lys Lys Ser Ala Gln Leu Phe Phe Val Val Phe Glu Trp Lys 
        275                 280                 285             


Asp Pro Phe Ile Gln Lys Val Gln Asp Ile Val Thr Ala Asn Pro Trp 
    290                 295                 300                 


Asn Thr Ile Ala Leu Leu Cys Gly Ala Phe Leu Ala Leu Phe Lys Ala 
305                 310                 315                 320 


Ala Glu Phe Ala Lys Leu Ser Ile Lys Trp Met Ile Lys Ile Arg Lys 
                325                 330                 335     


Arg Tyr Leu Lys Arg Arg Gly Gln Ala Thr Ser His Ile Ser 
            340                 345                 350 


<210>  4410
<211>  732
<212>  PRT
<213>  Homo sapiens

<400>  4410

Met Asp Pro Ser Ala Asp Thr Trp Asp Leu Phe Ser Pro Leu Ile Ser 
1               5                   10                  15      


Leu Trp Ile Asn Arg Phe Tyr Ile Tyr Leu Gly Phe Ala Val Ser Ile 
            20                  25                  30          


Ser Leu Trp Ile Cys Val Gln Ile Val Ile Lys Thr Gln Gly Lys Asn 
        35                  40                  45              


Leu Gln Glu Lys Ser Val Pro Lys Ala Ala Gln Asp Leu Met Thr Asn 
    50                  55                  60                  


Gly Tyr Val Ser Leu Gln Glu Lys Asp Ile Phe Val Ser Gly Val Lys 
65                  70                  75                  80  


Ile Phe Tyr Gly Ser Gln Thr Gly Thr Ala Lys Gly Phe Ala Thr Val 
                85                  90                  95      


Leu Ala Glu Ala Val Thr Ser Leu Asp Leu Pro Val Ala Ile Ile Asn 
            100                 105                 110         


Leu Lys Glu Tyr Asp Pro Asp Asp His Leu Ile Glu Glu Val Thr Ser 
        115                 120                 125             


Lys Asn Val Cys Val Phe Leu Val Ala Thr Tyr Thr Asp Gly Leu Pro 
    130                 135                 140                 


Thr Glu Ser Ala Glu Trp Phe Cys Lys Trp Leu Glu Glu Ala Ser Ile 
145                 150                 155                 160 


Asp Phe Arg Phe Gly Lys Thr Tyr Leu Lys Gly Met Arg Tyr Ala Val 
                165                 170                 175     


Phe Gly Leu Gly Asn Ser Ala Tyr Ala Ser His Phe Asn Lys Val Gly 
            180                 185                 190         


Lys Asn Val Asp Lys Trp Leu Trp Met Leu Gly Ala His Arg Val Met 
        195                 200                 205             


Ser Arg Gly Glu Gly Asp Cys Asp Val Val Lys Ser Lys His Gly Ser 
    210                 215                 220                 


Ile Glu Ala Asp Phe Arg Ala Trp Lys Thr Lys Phe Ile Ser Gln Leu 
225                 230                 235                 240 


Gln Ala Leu Gln Lys Gly Glu Arg Lys Lys Ser Cys Gly Gly His Cys 
                245                 250                 255     


Lys Lys Gly Lys Cys Glu Ser His Gln His Gly Ser Glu Glu Arg Glu 
            260                 265                 270         


Glu Gly Ser His Glu Gln Asp Glu Leu His His Arg Asp Thr Glu Glu 
        275                 280                 285             


Glu Glu Pro Phe Glu Ser Ser Ser Glu Glu Glu Phe Gly Gly Glu Asp 
    290                 295                 300                 


His Gln Ser Leu Asn Ser Ile Val Asp Val Glu Asp Leu Gly Lys Ile 
305                 310                 315                 320 


Met Asp His Val Lys Lys Glu Lys Arg Glu Lys Glu Gln Gln Glu Glu 
                325                 330                 335     


Lys Ser Gly Leu Phe Arg Asn Met Gly Arg Asn Glu Asp Gly Glu Arg 
            340                 345                 350         


Arg Ala Met Ile Thr Pro Ala Leu Arg Glu Ala Leu Thr Lys Gln Gly 
        355                 360                 365             


Tyr Gln Leu Ile Gly Ser His Ser Gly Val Lys Leu Cys Arg Trp Thr 
    370                 375                 380                 


Lys Ser Met Leu Arg Gly Arg Gly Gly Cys Tyr Lys His Thr Phe Tyr 
385                 390                 395                 400 


Gly Ile Glu Ser His Arg Cys Met Glu Thr Thr Pro Ser Leu Ala Cys 
                405                 410                 415     


Ala Asn Lys Cys Val Phe Cys Trp Arg His His Thr Asn Pro Val Gly 
            420                 425                 430         


Thr Glu Trp Arg Trp Lys Met Asp Gln Pro Glu Met Ile Leu Lys Glu 
        435                 440                 445             


Ala Ile Glu Asn His Gln Asn Met Ile Lys Gln Phe Lys Gly Val Pro 
    450                 455                 460                 


Gly Val Lys Ala Glu Arg Phe Glu Glu Gly Met Thr Val Lys His Cys 
465                 470                 475                 480 


Ala Leu Ser Leu Val Gly Glu Pro Ile Met Tyr Pro Glu Ile Asn Arg 
                485                 490                 495     


Phe Leu Lys Leu Leu His Gln Cys Lys Ile Ser Ser Phe Leu Val Thr 
            500                 505                 510         


Asn Ala Gln Phe Pro Ala Glu Ile Arg Asn Leu Glu Pro Val Thr Gln 
        515                 520                 525             


Leu Tyr Val Ser Val Asp Ala Ser Thr Lys Asp Ser Leu Lys Lys Ile 
    530                 535                 540                 


Asp Arg Pro Leu Phe Lys Asp Phe Trp Gln Arg Phe Leu Asp Ser Leu 
545                 550                 555                 560 


Lys Ala Leu Ala Val Lys Gln Gln Arg Thr Val Tyr Arg Leu Thr Leu 
                565                 570                 575     


Val Lys Ala Trp Asn Val Asp Glu Leu Gln Ala Tyr Ala Gln Leu Val 
            580                 585                 590         


Ser Leu Gly Asn Pro Asp Phe Ile Glu Val Lys Gly Val Thr Tyr Cys 
        595                 600                 605             


Gly Glu Ser Ser Ala Ser Ser Leu Thr Met Ala His Val Pro Trp His 
    610                 615                 620                 


Glu Glu Val Val Gln Phe Val His Glu Leu Val Asp Leu Ile Pro Glu 
625                 630                 635                 640 


Tyr Glu Ile Ala Cys Glu His Glu His Ser Asn Cys Leu Leu Ile Ala 
                645                 650                 655     


His Arg Lys Phe Lys Ile Gly Gly Glu Trp Trp Thr Trp Ile Asp Tyr 
            660                 665                 670         


Asn Arg Phe Gln Glu Leu Ile Gln Glu Tyr Glu Asp Ser Gly Gly Ser 
        675                 680                 685             


Lys Thr Phe Ser Ala Lys Asp Tyr Met Ala Arg Thr Pro His Trp Ala 
    690                 695                 700                 


Leu Phe Gly Ala Ser Glu Arg Gly Phe Asp Pro Lys Asp Thr Arg His 
705                 710                 715                 720 


Gln Arg Lys Asn Lys Ser Lys Ala Ile Ser Gly Cys 
                725                 730         


<210>  4411
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  4411

Met Pro Gly Gly Arg Arg Gly Pro Ser Arg Gln Gln Leu Ser Arg Ser 
1               5                   10                  15      


Ala Leu Pro Ser Leu Gln Thr Leu Val Gly Gly Gly Cys Gly Asn Gly 
            20                  25                  30          


Thr Gly Leu Arg Asn Arg Asn Gly Ser Ala Ile Gly Leu Pro Val Pro 
        35                  40                  45              


Pro Ile Thr Ala Leu Ile Thr Pro Gly Pro Val Arg His Cys Gln Ile 
    50                  55                  60                  


Pro Asp Leu Pro Val Asp Gly Ser Leu Leu Phe Glu Phe Leu Phe Phe 
65                  70                  75                  80  


Ile Tyr Leu Leu Val Ala Leu Phe Ile Gln Tyr Ile Asn Ile Tyr Lys 
                85                  90                  95      


Thr Val Trp Trp Tyr Pro Tyr Asn His Pro Ala Ser Cys Thr Ser Leu 
            100                 105                 110         


Asn Phe His Leu Ile Asp Tyr His Leu Ala Ala Phe Ile Thr Val Met 
        115                 120                 125             


Leu Ala Arg Arg Leu Val Trp Ala Leu Ile Ser Glu Ala Thr Lys Ala 
    130                 135                 140                 


Gly Ala Ala Ser Met Ile His Tyr Met Val Leu Ile Ser Ala Arg Leu 
145                 150                 155                 160 


Val Leu Leu Thr Leu Cys Gly Trp Val Leu Cys Trp Thr Leu Val Asn 
                165                 170                 175     


Leu Phe Arg Ser His Ser Val Leu Asn Leu Leu Phe Leu Gly Tyr Pro 
            180                 185                 190         


Phe Gly Val Tyr Val Pro Leu Cys Cys Phe His Gln Asp Ser Arg Ala 
        195                 200                 205             


His Leu Leu Leu Thr Asp Tyr Asn Tyr Val Val Gln His Glu Ala Val 
    210                 215                 220                 


Glu Glu Ser Ala Ser Thr Val Gly Gly Leu Ala Lys Ser Lys Asp Phe 
225                 230                 235                 240 


Leu Ser Leu Leu Leu Glu Ser Leu Lys Glu Gln Phe Asn Asn Ala Thr 
                245                 250                 255     


Pro Ile Pro Thr His Ser Cys Pro Leu Ser Pro Asp Leu Ile Arg Asn 
            260                 265                 270         


Glu Val Glu Cys Leu Lys Ala Asp Phe Asn His Arg Ile Lys Glu Val 
        275                 280                 285             


Leu Phe Asn Ser Leu Phe Ser Ala Tyr Tyr Val Ala Phe Leu Pro Leu 
    290                 295                 300                 


Cys Phe Val Lys Ser Thr Gln Tyr Tyr Asp Met Arg Trp Ser Cys Glu 
305                 310                 315                 320 


His Leu Ile Met Val Trp Ile Asn Ala Phe Val Met Leu Thr Thr Gln 
                325                 330                 335     


Leu Leu Pro Ser Lys Tyr Cys Asp Leu Leu His Lys Ser Ala Ala His 
            340                 345                 350         


Leu Gly Lys Trp Gln Lys Leu Glu His Gly Ser Tyr Ser Asn Ala Pro 
        355                 360                 365             


Gln His Ile Trp Ser Glu Asn Thr Ile Trp Pro Gln Gly Val Leu Val 
    370                 375                 380                 


Arg His Ser Arg Cys Leu Tyr Arg Ala Met Gly Pro Tyr Asn Val Ala 
385                 390                 395                 400 


Val Pro Ser Asp Val Ser His Ala Arg Phe Tyr Phe Leu Phe His Arg 
                405                 410                 415     


Pro Leu Arg Leu Leu Asn Leu Leu Ile Leu Ile Glu Gly Ser Val Val 
            420                 425                 430         


Phe Tyr Gln Leu Tyr Ser Leu Leu Arg Ser Glu Lys Trp Asn His Thr 
        435                 440                 445             


Leu Ser Met Ala Leu Ile Leu Phe Cys Asn Tyr Tyr Val Leu Phe Lys 
    450                 455                 460                 


Leu Leu Arg Asp Arg Ile Val Leu Gly Arg Ala Tyr Ser Tyr Pro Leu 
465                 470                 475                 480 


Asn Ser Tyr Glu Leu Lys Ala Asn 
                485             


<210>  4412
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  4412

Met Thr Val Glu Leu Trp Leu Arg Leu Arg Gly Lys Gly Leu Ala Met 
1               5                   10                  15      


Leu His Val Thr Arg Gly Val Trp Gly Ser Arg Val Arg Val Trp Pro 
            20                  25                  30          


Leu Leu Pro Ala Leu Leu Gly Pro Pro Arg Ala Leu Ser Ser Leu Ala 
        35                  40                  45              


Ala Lys Met Gly Glu Tyr Arg Lys Met Trp Asn Pro Arg Glu Pro Arg 
    50                  55                  60                  


Asp Trp Ala Gln Gln Tyr Arg Glu Arg Phe Ile Pro Phe Ser Lys Glu 
65                  70                  75                  80  


Gln Leu Leu Arg Leu Leu Ile Gln Glu Phe His Ser Ser Pro Ala Glu 
                85                  90                  95      


Lys Ala Ala Leu Glu Ala Phe Ser Ala His Val Asp Phe Cys Thr Leu 
            100                 105                 110         


Phe His Tyr His Gln Ile Leu Ala Arg Leu Gln Ala Leu Tyr Asp Pro 
        115                 120                 125             


Ile Asn Pro Asp Arg Glu Thr Leu Asp Gln Pro Ser Leu Thr Asp Pro 
    130                 135                 140                 


Gln Arg Leu Ser Asn Glu Gln Glu Val Leu Arg Ala Leu Glu Pro Leu 
145                 150                 155                 160 


Leu Ala Gln Ala Asn Phe Ser Pro Leu Ser Glu Asp Thr Leu Ala Tyr 
                165                 170                 175     


Ala Leu Val Val His His Pro Gln Asp Glu Val Gln Val Thr Val Asn 
            180                 185                 190         


Leu Asp Gln Tyr Val Tyr Ile His Phe Trp Ala Leu Gly Gln Arg Val 
        195                 200                 205             


Gly Gln Met Pro Leu Lys Ser Ser Val Gly Ser Arg Arg Gly Phe Phe 
    210                 215                 220                 


Thr Lys Leu Pro Pro Ala Glu Arg Arg Tyr Phe Lys Arg Val Val Leu 
225                 230                 235                 240 


Ala Ala Arg Thr Lys Arg Gly His Leu Val Leu Lys Ser Phe Lys Asp 
                245                 250                 255     


Thr Pro Leu Glu Gly Leu Glu Gln Leu Leu Pro Glu Leu Lys Val Arg 
            260                 265                 270         


Thr Pro Thr Leu Gln Arg Ala Leu Leu Asn Leu Met Leu Val Val Ser 
        275                 280                 285             


Gly Val Ala Ile Phe Val Asn Val Gly Met Val Val Leu Thr Asp Leu 
    290                 295                 300                 


Lys Val Ala Thr Ser Leu Leu Leu Leu Leu Phe Ala Ile Phe Met Gly 
305                 310                 315                 320 


Leu Arg Ala Ser Lys Met Phe Gly Gln Arg Arg Ser Ala Gln Ala Leu 
                325                 330                 335     


Glu Leu Ala His Met Leu Tyr Tyr Arg Ser Thr Ser Asn Asn Ser Glu 
            340                 345                 350         


Leu Leu Ser Ala Leu Ala Leu Arg Ala Gln Asp Glu His Thr Lys Glu 
        355                 360                 365             


Ala Leu Leu Ala His Ser Phe Leu Ala Arg Arg Pro Gly Gly Thr Gln 
    370                 375                 380                 


Gly Ser Pro Glu Glu Thr Ser Arg Trp Leu Arg Ser Glu Val Glu Asn 
385                 390                 395                 400 


Trp Leu Leu Ala Lys Ser Gly Cys Glu Val Thr Phe Asn Gly Thr Arg 
                405                 410                 415     


Ala Leu Ala His Leu Gln Ala Leu Thr Pro Ser Met Gly Leu Tyr Pro 
            420                 425                 430         


Pro Pro Gly Phe Pro Lys Leu Asp Pro Val Ala Pro Ile Thr Ser Glu 
        435                 440                 445             


Pro Pro Gln Ala Thr Pro Ser Ser Asn Ile Ser 
    450                 455                 


<210>  4413
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  4413

Met Thr Asp Leu Asn Asp Asn Ile Cys Lys Arg Tyr Ile Lys Met Ile 
1               5                   10                  15      


Thr Asn Ile Val Ile Leu Ser Leu Ile Ile Cys Ile Ser Leu Ala Phe 
            20                  25                  30          


Trp Ile Ile Ser Met Thr Ala Ser Thr Tyr Tyr Gly Asn Leu Arg Pro 
        35                  40                  45              


Ile Ser Pro Trp Arg Trp Leu Phe Ser Val Val Val Pro Val Leu Ile 
    50                  55                  60                  


Val Ser Asn Gly Leu Lys Lys Lys Ser Leu Asp His Ser Gly Ala Leu 
65                  70                  75                  80  


Gly Gly Leu Val Val Gly Phe Ile Leu Thr Ile Ala Asn Phe Ser Phe 
                85                  90                  95      


Phe Thr Ser Leu Leu Met Phe Phe Leu Ser Ser Ser Lys Leu Thr Lys 
            100                 105                 110         


Trp Lys Gly Glu Val Lys Lys Arg Leu Asp Ser Glu Tyr Lys Glu Gly 
        115                 120                 125             


Gly Gln Arg Asn Trp Val Gln Val Phe Cys Asn Gly Ala Val Pro Thr 
    130                 135                 140                 


Glu Leu Ala Leu Leu Tyr Met Ile Glu Asn Gly Pro Gly Glu Ile Pro 
145                 150                 155                 160 


Val Asp Phe Ser Lys Gln Tyr Ser Ala Ser Trp Met Cys Leu Ser Leu 
                165                 170                 175     


Leu Ala Ala Leu Ala Cys Ser Ala Gly Asp Thr Trp Ala Ser Glu Val 
            180                 185                 190         


Gly Pro Val Leu Ser Lys Ser Ser Pro Arg Leu Ile Thr Thr Trp Glu 
        195                 200                 205             


Lys Val Pro Val Gly Thr Asn Gly Gly Val Thr Val Val Gly Leu Val 
    210                 215                 220                 


Ser Ser Leu Leu Gly Gly Thr Phe Val Gly Ile Ala Tyr Phe Leu Thr 
225                 230                 235                 240 


Gln Leu Ile Phe Val Asn Asp Leu Asp Ile Ser Ala Pro Gln Trp Pro 
                245                 250                 255     


Ile Ile Ala Phe Gly Gly Leu Ala Gly Leu Leu Gly Ser Ile Val Asp 
            260                 265                 270         


Ser Tyr Leu Gly Ala Thr Met Gln Tyr Thr Gly Leu Asp Glu Ser Thr 
        275                 280                 285             


Gly Met Val Val Asn Ser Pro Thr Asn Lys Ala Arg His Ile Ala Gly 
    290                 295                 300                 


Lys Pro Ile Leu Asp Asn Asn Ala Val Asn Leu Phe Ser Ser Val Leu 
305                 310                 315                 320 


Ile Ala Leu Leu Leu Pro Thr Ala Ala Trp Gly Phe Trp Pro Arg Gly 
                325                 330                 335     


<210>  4414
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  4414

Met Thr Glu Glu Pro Ile Lys Glu Ile Leu Gly Ala Pro Lys Ala His 
1               5                   10                  15      


Met Ala Ala Thr Met Glu Lys Ser Pro Lys Ser Glu Val Val Ile Thr 
            20                  25                  30          


Thr Val Pro Leu Val Ser Glu Ile Gln Leu Met Ala Ala Thr Gly Gly 
        35                  40                  45              


Thr Glu Leu Ser Cys Tyr Arg Cys Ile Ile Pro Phe Ala Val Val Val 
    50                  55                  60                  


Phe Ile Ala Gly Ile Val Val Thr Ala Val Ala Tyr Ser Phe Asn Ser 
65                  70                  75                  80  


His Gly Ser Ile Ile Ser Ile Phe Gly Leu Val Val Leu Ser Ser Gly 
                85                  90                  95      


Leu Phe Leu Leu Ala Ser Ser Ala Leu Cys Trp Lys Val Arg Gln Arg 
            100                 105                 110         


Ser Lys Lys Ala Lys Arg Arg Glu Ser Gln Thr Ala Leu Val Ala Asn 
        115                 120                 125             


Gln Arg Ser Leu Phe Ala 
    130                 


<210>  4415
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  4415

Met Ala Gly Pro Arg Pro Arg Trp Arg Asp Gln Leu Leu Phe Met Ser 
1               5                   10                  15      


Ile Ile Val Leu Val Ile Val Val Ile Cys Leu Met Phe Tyr Ala Leu 
            20                  25                  30          


Leu Trp Glu Ala Gly Asn Leu Thr Asp Leu Pro Asn Leu Arg Ile Gly 
        35                  40                  45              


Phe Tyr Asn Phe Cys Leu Trp Asn Glu Asp Thr Ser Thr Leu Gln Cys 
    50                  55                  60                  


His Gln Phe Pro Glu Leu Glu Ala Leu Gly Val Pro Arg Val Gly Leu 
65                  70                  75                  80  


Gly Leu Ala Arg Leu Gly Val Tyr Gly Ser Leu Val Leu Thr Leu Phe 
                85                  90                  95      


Ala Pro Gln Pro Leu Leu Leu Ala Gln Cys Asn Ser Asp Glu Arg Ala 
            100                 105                 110         


Trp Arg Leu Ala Val Gly Phe Leu Ala Val Ser Ser Val Leu Leu Ala 
        115                 120                 125             


Gly Gly Leu Gly Leu Phe Leu Ser Tyr Val Trp Lys Trp Val Arg Leu 
    130                 135                 140                 


Ser Leu Pro Gly Pro Gly Phe Leu Ala Leu Gly Ser Ala Gln Ala Leu 
145                 150                 155                 160 


Leu Ile Leu Leu Leu Ile Ala Met Ala Val Phe Pro Leu Arg Ala Glu 
                165                 170                 175     


Arg Ala Glu Ser Lys Leu Glu Ser Cys 
            180                 185 


<210>  4416
<211>  654
<212>  PRT
<213>  Homo sapiens

<400>  4416

Met Ala Ala Ala Ala Leu Gly Ser Ser Ser Gly Ser Ala Ser Pro Ala 
1               5                   10                  15      


Val Ala Glu Leu Cys Gln Asn Thr Pro Glu Thr Phe Leu Glu Ala Ser 
            20                  25                  30          


Lys Leu Leu Leu Thr Tyr Ala Asp Asn Ile Leu Arg Asn Pro Asn Asp 
        35                  40                  45              


Glu Lys Tyr Arg Ser Ile Arg Ile Gly Asn Thr Ala Phe Ser Thr Arg 
    50                  55                  60                  


Leu Leu Pro Val Arg Gly Ala Val Glu Cys Leu Phe Glu Met Gly Phe 
65                  70                  75                  80  


Glu Glu Gly Glu Thr His Leu Ile Phe Pro Lys Lys Ala Ser Val Glu 
                85                  90                  95      


Gln Leu Gln Lys Ile Arg Asp Leu Ile Ala Ile Glu Arg Ser Ser Arg 
            100                 105                 110         


Leu Asp Gly Ser Asn Lys Ser His Lys Val Lys Ser Ser Gln Gln Pro 
        115                 120                 125             


Ala Ala Ser Thr Gln Leu Pro Thr Thr Pro Ser Ser Asn Pro Ser Gly 
    130                 135                 140                 


Leu Asn Gln His Thr Arg Asn Arg Gln Gly Gln Ser Ser Asp Pro Pro 
145                 150                 155                 160 


Ser Ala Ser Thr Val Ala Ala Asp Ser Ala Ile Leu Glu Val Leu Gln 
                165                 170                 175     


Ser Asn Ile Gln His Val Leu Val Tyr Glu Asn Pro Ala Leu Gln Glu 
            180                 185                 190         


Lys Ala Leu Ala Cys Ile Pro Val Gln Glu Leu Lys Arg Lys Ser Gln 
        195                 200                 205             


Glu Lys Leu Ser Arg Ala Arg Lys Leu Asp Lys Gly Ile Asn Ile Ser 
    210                 215                 220                 


Asp Glu Asp Phe Leu Leu Leu Glu Leu Leu His Trp Phe Lys Glu Glu 
225                 230                 235                 240 


Phe Phe His Trp Val Asn Asn Val Leu Cys Ser Lys Cys Gly Gly Gln 
                245                 250                 255     


Thr Arg Ser Arg Asp Arg Ser Leu Leu Pro Ser Asp Asp Glu Leu Lys 
            260                 265                 270         


Trp Gly Ala Lys Glu Val Glu Asp His Tyr Cys Asp Ala Cys Gln Phe 
        275                 280                 285             


Ser Asn Arg Phe Pro Arg Tyr Asn Asn Pro Glu Lys Leu Leu Glu Thr 
    290                 295                 300                 


Arg Cys Gly Arg Cys Gly Glu Trp Ala Asn Cys Phe Thr Leu Cys Cys 
305                 310                 315                 320 


Arg Ala Val Gly Phe Glu Ala Arg Tyr Val Trp Asp Tyr Thr Asp His 
                325                 330                 335     


Val Trp Thr Glu Val Tyr Ser Pro Ser Gln Gln Arg Trp Leu His Cys 
            340                 345                 350         


Asp Ala Cys Glu Asp Val Cys Asp Lys Pro Leu Leu Tyr Glu Ile Gly 
        355                 360                 365             


Trp Gly Lys Lys Leu Ser Tyr Val Ile Ala Phe Ser Lys Asp Glu Val 
    370                 375                 380                 


Val Asp Val Thr Trp Arg Tyr Ser Cys Lys His Glu Glu Val Ile Ala 
385                 390                 395                 400 


Arg Arg Thr Lys Val Lys Glu Ala Leu Leu Arg Asp Thr Ile Asn Gly 
                405                 410                 415     


Leu Asn Lys Gln Arg Gln Leu Phe Leu Ser Glu Asn Arg Arg Lys Glu 
            420                 425                 430         


Leu Leu Gln Arg Ile Ile Val Glu Leu Val Glu Phe Ile Ser Pro Lys 
        435                 440                 445             


Thr Pro Lys Pro Gly Glu Leu Gly Gly Arg Ile Ser Gly Ser Val Ala 
    450                 455                 460                 


Trp Arg Val Ala Arg Gly Glu Met Gly Leu Gln Arg Lys Glu Thr Leu 
465                 470                 475                 480 


Phe Ile Pro Cys Glu Asn Glu Lys Ile Ser Lys Gln Leu His Leu Cys 
                485                 490                 495     


Tyr Asn Ile Val Lys Asp Arg Tyr Val Arg Val Ser Asn Asn Asn Gln 
            500                 505                 510         


Thr Ile Ser Gly Trp Glu Asn Gly Val Trp Lys Met Glu Ser Ile Phe 
        515                 520                 525             


Arg Lys Val Glu Thr Asp Trp His Met Val Tyr Leu Ala Arg Lys Glu 
    530                 535                 540                 


Gly Ser Ser Phe Ala Tyr Ile Ser Trp Lys Phe Glu Cys Gly Ser Val 
545                 550                 555                 560 


Gly Leu Lys Val Asp Ser Ile Ser Ile Arg Thr Ser Ser Gln Thr Phe 
                565                 570                 575     


Gln Thr Gly Thr Val Glu Trp Lys Leu Arg Ser Asp Thr Ala Gln Val 
            580                 585                 590         


Glu Leu Thr Gly Asp Asn Ser Leu His Ser Tyr Ala Asp Phe Ser Gly 
        595                 600                 605             


Ala Thr Glu Val Ile Leu Glu Ala Glu Leu Ser Arg Gly Asp Gly Asp 
    610                 615                 620                 


Val Ala Trp Gln His Thr Gln Leu Phe Arg Gln Ser Leu Asn Asp His 
625                 630                 635                 640 


Glu Glu Asn Cys Leu Glu Ile Ile Ile Lys Phe Ser Asp Leu 
                645                 650                 


<210>  4417
<211>  553
<212>  PRT
<213>  Homo sapiens

<400>  4417

Met Ala Asp Pro Glu Val Val Val Ser Ser Cys Ser Ser His Glu Glu 
1               5                   10                  15      


Glu Asn Arg Cys Asn Phe Asn Gln Gln Thr Ser Pro Ser Glu Glu Leu 
            20                  25                  30          


Leu Leu Glu Asp Gln Met Arg Arg Lys Leu Lys Phe Phe Phe Met Asn 
        35                  40                  45              


Pro Cys Glu Lys Phe Trp Ala Arg Gly Arg Lys Pro Trp Lys Leu Ala 
    50                  55                  60                  


Ile Gln Ile Leu Lys Ile Ala Met Val Thr Ile Gln Leu Val Leu Phe 
65                  70                  75                  80  


Gly Leu Ser Asn Gln Met Val Val Ala Phe Lys Glu Glu Asn Thr Ile 
                85                  90                  95      


Ala Phe Lys His Leu Phe Leu Lys Gly Tyr Met Asp Arg Met Asp Asp 
            100                 105                 110         


Thr Tyr Ala Val Tyr Thr Gln Ser Asp Val Tyr Asp Gln Leu Ile Phe 
        115                 120                 125             


Ala Val Asn Gln Tyr Leu Gln Leu Tyr Asn Val Ser Val Gly Asn His 
    130                 135                 140                 


Ala Tyr Glu Asn Lys Gly Thr Lys Gln Ser Ala Met Ala Ile Cys Gln 
145                 150                 155                 160 


His Phe Tyr Lys Arg Gly Asn Ile Tyr Pro Gly Asn Asp Thr Phe Asp 
                165                 170                 175     


Ile Asp Pro Glu Ile Glu Thr Glu Cys Phe Phe Val Glu Pro Asp Glu 
            180                 185                 190         


Pro Phe His Ile Gly Thr Pro Ala Glu Asn Lys Leu Asn Leu Thr Leu 
        195                 200                 205             


Asp Phe His Arg Leu Leu Thr Val Glu Leu Gln Phe Lys Leu Lys Ala 
    210                 215                 220                 


Ile Asn Leu Gln Thr Val Arg His Gln Glu Leu Pro Asp Cys Tyr Asp 
225                 230                 235                 240 


Phe Thr Leu Thr Ile Thr Phe Asp Asn Lys Ala His Ser Gly Arg Ile 
                245                 250                 255     


Lys Ile Ser Leu Asp Asn Asp Ile Ser Ile Arg Glu Cys Lys Asp Trp 
            260                 265                 270         


His Val Ser Gly Ser Ile Gln Lys Asn Thr His Tyr Met Met Ile Phe 
        275                 280                 285             


Asp Ala Phe Val Ile Leu Thr Cys Leu Val Ser Leu Ile Leu Cys Ile 
    290                 295                 300                 


Arg Ser Val Ile Arg Gly Leu Gln Leu Gln Gln Glu Phe Val Asn Phe 
305                 310                 315                 320 


Phe Leu Leu His Tyr Lys Lys Glu Val Ser Val Ser Asp Gln Met Glu 
                325                 330                 335     


Phe Val Asn Gly Trp Tyr Ile Met Ile Ile Ile Ser Asp Ile Leu Thr 
            340                 345                 350         


Ile Ile Gly Ser Ile Leu Lys Met Glu Ile Gln Ala Lys Ser Leu Thr 
        355                 360                 365             


Ser Tyr Asp Val Cys Ser Ile Leu Leu Gly Thr Ser Thr Met Leu Val 
    370                 375                 380                 


Trp Leu Gly Val Ile Arg Tyr Leu Gly Phe Phe Ala Lys Tyr Asn Leu 
385                 390                 395                 400 


Leu Ile Leu Thr Leu Gln Ala Ala Leu Pro Asn Val Ile Arg Phe Cys 
                405                 410                 415     


Cys Cys Ala Ala Met Ile Tyr Leu Gly Tyr Cys Phe Cys Gly Trp Ile 
            420                 425                 430         


Val Leu Gly Pro Tyr His Asp Lys Phe Arg Ser Leu Asn Met Val Ser 
        435                 440                 445             


Glu Cys Leu Phe Ser Leu Ile Asn Gly Asp Asp Met Phe Ala Thr Phe 
    450                 455                 460                 


Ala Lys Met Gln Gln Lys Ser Tyr Leu Val Trp Leu Phe Ser Arg Ile 
465                 470                 475                 480 


Tyr Leu Tyr Ser Phe Ile Ser Leu Phe Ile Tyr Met Ile Leu Ser Leu 
                485                 490                 495     


Phe Ile Ala Leu Ile Thr Asp Thr Tyr Glu Thr Ile Lys Gln Tyr Gln 
            500                 505                 510         


Gln Asp Gly Phe Pro Glu Thr Glu Leu Arg Thr Phe Ile Ser Glu Cys 
        515                 520                 525             


Lys Asp Leu Pro Asn Ser Gly Lys Tyr Arg Leu Glu Asp Asp Pro Pro 
    530                 535                 540                 


Val Ser Leu Phe Cys Cys Cys Lys Lys 
545                 550             


<210>  4418
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  4418

Met Glu Thr Ser Ala Ser Ser Ser Gln Pro Gln Asp Asn Ser Gln Val 
1               5                   10                  15      


His Arg Glu Thr Glu Asp Val Asp Tyr Gly Glu Thr Asp Phe His Lys 
            20                  25                  30          


Gln Asp Gly Lys Ala Gly Leu Phe Ser Gln Glu Gln Tyr Glu Arg Asn 
        35                  40                  45              


Lys Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
    50                  55                  60                  


Ser Ser Ser Ser Ser Ser Glu Ser Asn Asp Glu Asp Gln Gln Pro Arg 
65                  70                  75                  80  


Ala Thr Gly Lys His Arg Arg Ser Leu Gly Ala Gly Tyr Pro His Gly 
                85                  90                  95      


Asn Gly Ser Pro Gly Pro Gly His Gly Glu Pro Asp Val Leu Lys Asp 
            100                 105                 110         


Glu Leu Gln Leu Tyr Gly Asp Ala Pro Gly Glu Val Val Pro Ser Gly 
        115                 120                 125             


Glu Ser Gly Leu Arg Arg Arg Gly Ser Asp Pro Ala Ser Gly Glu Val 
    130                 135                 140                 


Glu Ala Ser Gln Leu Arg Arg Leu Asn Ile Lys Lys Asp Asp Glu Phe 
145                 150                 155                 160 


Phe His Phe Val Leu Leu Cys Phe Ala Ile Gly Ala Leu Leu Val Cys 
                165                 170                 175     


Tyr His Tyr Tyr Ala Asp Trp Phe Met Ser Leu Gly Val Gly Leu Leu 
            180                 185                 190         


Thr Phe Ala Ser Leu Glu Thr Val Gly Ile Tyr Phe Gly Leu Val Tyr 
        195                 200                 205             


Arg Ile His Ser Val Leu Gln Gly Phe Ile Pro Leu Phe Gln Lys Phe 
    210                 215                 220                 


Arg Leu Thr Gly Phe Arg Lys Thr Asp 
225                 230             


<210>  4419
<211>  627
<212>  PRT
<213>  Homo sapiens

<400>  4419

Met Cys Val Pro Arg Ser Gly Leu Ile Leu Ser Cys Ile Cys Leu Tyr 
1               5                   10                  15      


Cys Gly Val Leu Leu Pro Val Leu Leu Pro Asn Leu Pro Phe Leu Thr 
            20                  25                  30          


Cys Leu Ser Met Ser Thr Leu Glu Ser Val Thr Tyr Leu Pro Glu Lys 
        35                  40                  45              


Gly Leu Tyr Cys Gln Arg Leu Pro Ser Ser Arg Thr His Gly Gly Thr 
    50                  55                  60                  


Glu Ser Leu Lys Gly Lys Asn Thr Glu Asn Met Gly Phe Tyr Gly Thr 
65                  70                  75                  80  


Leu Lys Met Ile Phe Tyr Lys Met Lys Arg Lys Leu Asp His Gly Ser 
                85                  90                  95      


Glu Val Arg Ser Phe Ser Leu Gly Lys Lys Pro Cys Lys Val Ser Glu 
            100                 105                 110         


Tyr Thr Ser Thr Thr Gly Leu Val Pro Cys Ser Ala Thr Pro Thr Thr 
        115                 120                 125             


Phe Gly Asp Leu Arg Ala Ala Asn Gly Gln Gly Gln Gln Arg Arg Arg 
    130                 135                 140                 


Ile Thr Ser Val Gln Pro Pro Thr Gly Leu Gln Glu Trp Leu Lys Met 
145                 150                 155                 160 


Phe Gln Ser Trp Ser Gly Pro Glu Lys Leu Leu Ala Leu Asp Glu Leu 
                165                 170                 175     


Ile Asp Ser Cys Glu Pro Thr Gln Val Lys His Met Met Gln Val Ile 
            180                 185                 190         


Glu Pro Gln Phe Gln Arg Asp Phe Ile Ser Leu Leu Pro Lys Glu Leu 
        195                 200                 205             


Ala Leu Tyr Val Leu Ser Phe Leu Glu Pro Lys Asp Leu Leu Gln Ala 
    210                 215                 220                 


Ala Gln Thr Cys Arg Tyr Trp Arg Ile Leu Ala Glu Asp Asn Leu Leu 
225                 230                 235                 240 


Trp Arg Glu Lys Cys Lys Glu Glu Gly Ile Asp Glu Pro Leu His Ile 
                245                 250                 255     


Lys Arg Arg Lys Val Ile Lys Pro Gly Phe Ile His Ser Pro Trp Lys 
            260                 265                 270         


Ser Ala Tyr Ile Arg Gln His Arg Ile Asp Thr Asn Trp Arg Arg Gly 
        275                 280                 285             


Glu Leu Lys Ser Pro Lys Val Leu Lys Gly His Asp Asp His Val Ile 
    290                 295                 300                 


Thr Cys Leu Gln Phe Cys Gly Asn Arg Ile Val Ser Gly Ser Asp Asp 
305                 310                 315                 320 


Asn Thr Leu Lys Val Trp Ser Ala Val Thr Gly Lys Cys Leu Arg Thr 
                325                 330                 335     


Leu Val Gly His Thr Gly Gly Val Trp Ser Ser Gln Met Arg Asp Asn 
            340                 345                 350         


Ile Ile Ile Ser Gly Ser Thr Asp Arg Thr Leu Lys Val Trp Asn Ala 
        355                 360                 365             


Glu Thr Gly Glu Cys Ile His Thr Leu Tyr Gly His Thr Ser Thr Val 
    370                 375                 380                 


Arg Cys Met His Leu His Glu Lys Arg Val Val Ser Gly Ser Arg Asp 
385                 390                 395                 400 


Ala Thr Leu Arg Val Trp Asp Ile Glu Thr Gly Gln Cys Leu His Val 
                405                 410                 415     


Leu Met Gly His Val Ala Ala Val Arg Cys Val Gln Tyr Asp Gly Arg 
            420                 425                 430         


Arg Val Val Ser Gly Ala Tyr Asp Phe Met Val Lys Val Trp Asp Pro 
        435                 440                 445             


Glu Thr Glu Thr Cys Leu His Thr Leu Gln Gly His Thr Asn Arg Val 
    450                 455                 460                 


Tyr Ser Leu Gln Phe Asp Gly Ile His Val Val Ser Gly Ser Leu Asp 
465                 470                 475                 480 


Thr Ser Ile Arg Val Trp Asp Val Glu Thr Gly Asn Cys Ile His Thr 
                485                 490                 495     


Leu Thr Gly His Gln Ser Leu Thr Ser Gly Met Glu Leu Lys Asp Asn 
            500                 505                 510         


Ile Leu Val Ser Gly Asn Ala Asp Ser Thr Val Lys Ile Trp Asp Ile 
        515                 520                 525             


Lys Thr Gly Gln Cys Leu Gln Thr Leu Gln Gly Pro Asn Lys His Gln 
    530                 535                 540                 


Ser Ala Val Thr Cys Leu Gln Phe Asn Lys Asn Phe Val Ile Thr Ser 
545                 550                 555                 560 


Ser Asp Asp Gly Thr Val Lys Leu Trp Asp Leu Lys Thr Gly Glu Phe 
                565                 570                 575     


Ile Arg Asn Leu Val Thr Leu Glu Ser Gly Gly Ser Gly Gly Val Val 
            580                 585                 590         


Trp Arg Ile Arg Ala Ser Asn Thr Lys Leu Val Cys Ala Val Gly Ser 
        595                 600                 605             


Arg Asn Gly Thr Glu Glu Thr Lys Leu Leu Val Leu Asp Phe Asp Val 
    610                 615                 620                 


Asp Met Lys 
625         


<210>  4420
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  4420

Met Ala Ala Val Val Glu Val Glu Val Gly Gly Gly Ala Ala Gly Glu 
1               5                   10                  15      


Arg Glu Leu Asp Glu Val Asp Met Ser Asp Leu Ser Pro Glu Glu Gln 
            20                  25                  30          


Trp Arg Val Glu His Ala Arg Met His Ala Lys His Arg Gly His Glu 
        35                  40                  45              


Ala Met His Ala Glu Met Val Leu Ile Leu Ile Ala Thr Leu Val Val 
    50                  55                  60                  


Ala Gln Leu Leu Leu Val Gln Trp Lys Gln Arg His Pro Arg Ser Tyr 
65                  70                  75                  80  


Asn Met Val Thr Leu Phe Gln Met Trp Val Val Pro Leu Tyr Phe Thr 
                85                  90                  95      


Val Lys Leu His Trp Trp Arg Phe Leu Val Ile Trp Ile Leu Phe Ser 
            100                 105                 110         


Ala Val Thr Ala Phe Val Thr Phe Arg Ala Thr Arg Lys Pro Leu Val 
        115                 120                 125             


Gln Thr Thr Pro Arg Leu Val Tyr Lys Trp Phe Leu Leu Ile Tyr Lys 
    130                 135                 140                 


Ile Ser Tyr Ala Thr Gly Ile Val Gly Tyr Met Ala Val Met Phe Thr 
145                 150                 155                 160 


Leu Phe Gly Leu Asn Leu Leu Phe Lys Ile Lys Pro Glu Asp Ala Met 
                165                 170                 175     


Asp Phe Gly Ile Ser Leu Leu Phe Tyr Gly Leu Tyr Tyr Gly Val Leu 
            180                 185                 190         


Glu Arg Asp Phe Ala Glu Met Cys Ala Asp Tyr Met Ala Ser Thr Ile 
        195                 200                 205             


Gly Phe Tyr Ser Glu Ser Gly Met Pro Thr Lys His Leu Ser Asp Ser 
    210                 215                 220                 


Val Cys Ala Val Cys Gly Gln Gln Ile Phe Val Asp Val Ser Glu Glu 
225                 230                 235                 240 


Gly Ile Ile Glu Asn Thr Tyr Arg Leu Ser Cys Asn His Val Phe His 
                245                 250                 255     


Glu Phe Cys Ile Arg Gly Trp Cys Ile Val Gly Lys Lys Gln Thr Cys 
            260                 265                 270         


Pro Tyr Cys Lys Glu Lys Val Asp Leu Lys Arg Met Phe Ser Asn Pro 
        275                 280                 285             


Trp Glu Arg Pro His Val Met Tyr Gly Gln Leu Leu Asp Trp Leu Arg 
    290                 295                 300                 


Tyr Leu Val Ala Trp Gln Pro Val Ile Ile Gly Val Val Gln Gly Ile 
305                 310                 315                 320 


Asn Tyr Ile Leu Gly Leu Glu 
                325         


<210>  4421
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  4421

Met Glu Gln Arg Leu Ala Glu Phe Arg Ala Ala Arg Lys Arg Ala Gly 
1               5                   10                  15      


Leu Ala Ala Gln Pro Pro Ala Ala Ser Gln Gly Ala Gln Thr Pro Gly 
            20                  25                  30          


Glu Lys Ala Glu Ala Ala Ala Thr Leu Lys Ala Ala Pro Gly Trp Leu 
        35                  40                  45              


Lys Arg Phe Leu Val Trp Lys Pro Arg Pro Ala Ser Ala Arg Ala Gln 
    50                  55                  60                  


Pro Gly Leu Val Gln Glu Ala Ala Gln Pro Gln Gly Ser Thr Ser Glu 
65                  70                  75                  80  


Thr Pro Trp Asn Thr Ala Ile Pro Leu Pro Ser Cys Trp Asp Gln Ser 
                85                  90                  95      


Phe Leu Thr Asn Ile Thr Phe Leu Lys Val Leu Leu Trp Leu Val Leu 
            100                 105                 110         


Leu Gly Leu Phe Val Glu Leu Glu Phe Gly Leu Ala Tyr Phe Val Leu 
        115                 120                 125             


Ser Leu Phe Tyr Trp Met Tyr Val Gly Thr Arg Gly Pro Glu Glu Lys 
    130                 135                 140                 


Lys Glu Gly Glu Lys Ser Ala Tyr Ser Val Phe Asn Pro Gly Cys Glu 
145                 150                 155                 160 


Ala Ile Gln Gly Thr Leu Thr Ala Glu Gln Leu Glu Arg Glu Leu Gln 
                165                 170                 175     


Leu Arg Pro Leu Ala Gly Arg 
            180             


<210>  4422
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  4422

Met Ala Asn Pro Gly Gly Gly Ala Val Cys Asn Gly Lys Leu His Asn 
1               5                   10                  15      


His Lys Lys Gln Ser Asn Gly Ser Gln Ser Arg Asn Cys Thr Lys Asn 
            20                  25                  30          


Gly Ile Val Lys Glu Ala Gln Gln Asn Gly Lys Pro His Phe Tyr Asp 
        35                  40                  45              


Lys Leu Ile Val Glu Ser Phe Glu Glu Ala Pro Leu His Val Met Val 
    50                  55                  60                  


Phe Thr Tyr Met Gly Tyr Gly Ile Gly Thr Leu Phe Gly Tyr Leu Arg 
65                  70                  75                  80  


Asp Phe Leu Arg Asn Trp Gly Ile Glu Lys Cys Asn Ala Ala Val Glu 
                85                  90                  95      


Arg Lys Glu Gln Lys Asp Phe Val Pro Leu Tyr Gln Asp Phe Glu Asn 
            100                 105                 110         


Phe Tyr Thr Arg Asn Leu Tyr Met Arg Ile Arg Asp Asn Trp Asn Arg 
        115                 120                 125             


Pro Ile Cys Ser Ala Pro Gly Pro Leu Phe Asp Leu Met Glu Arg Val 
    130                 135                 140                 


Ser Asp Asp Tyr Asn Trp Thr Phe Arg Phe Thr Gly Arg Val Ile Lys 
145                 150                 155                 160 


Asp Val Ile Asn Met Gly Ser Tyr Asn Phe Leu Gly Leu Ala Ala Lys 
                165                 170                 175     


Tyr Asp Glu Ser Met Arg Thr Ile Lys Asp Val Leu Glu Val Tyr Gly 
            180                 185                 190         


Thr Gly Val Ala Ser Thr Arg His Glu Met Gly Thr Leu Asp Lys His 
        195                 200                 205             


Lys Glu Leu Glu Asp Leu Val Ala Lys Phe Leu Asn Val Glu Ala Ala 
    210                 215                 220                 


Met Val Phe Gly Met Gly Phe Ala Thr Asn Ser Met Asn Ile Pro Ala 
225                 230                 235                 240 


Leu Val Gly Lys Gly Cys Leu Ile Leu Ser Asp Glu Leu Asn His Thr 
                245                 250                 255     


Ser Leu Val Leu Gly Ala Arg Leu Ser Gly Ala Thr Ile Arg Ile Phe 
            260                 265                 270         


Lys His Asn Asn Thr Gln Ser Leu Glu Lys Leu Leu Arg Asp Ala Val 
        275                 280                 285             


Ile Tyr Gly Gln Pro Arg Thr Arg Arg Ala Trp Lys Lys Ile Leu Ile 
    290                 295                 300                 


Leu Val Glu Gly Val Tyr Ser Met Glu Gly Ser Ile Val His Leu Pro 
305                 310                 315                 320 


Gln Ile Ile Ala Leu Lys Lys Lys Tyr Lys Ala Tyr Leu Tyr Ile Asp 
                325                 330                 335     


Glu Ala His Ser Ile Gly Ala Val Gly Pro Thr Gly Arg Gly Val Thr 
            340                 345                 350         


Glu Phe Phe Gly Leu Asp Pro His Glu Val Asp Val Leu Met Gly Thr 
        355                 360                 365             


Phe Thr Lys Ser Phe Gly Ala Ser Gly Gly Tyr Ile Ala Gly Arg Lys 
    370                 375                 380                 


Asp Leu Val Asp Tyr Leu Arg Val His Ser His Ser Ala Val Tyr Ala 
385                 390                 395                 400 


Ser Ser Met Ser Pro Pro Ile Ala Glu Gln Ile Ile Arg Ser Leu Lys 
                405                 410                 415     


Leu Ile Met Gly Leu Asp Gly Thr Thr Gln Gly Leu Gln Arg Val Gln 
            420                 425                 430         


Gln Leu Ala Lys Asn Thr Arg Tyr Phe Arg Gln Arg Leu Gln Glu Met 
        435                 440                 445             


Gly Phe Ile Ile Tyr Gly Asn Glu Asn Ala Ser Val Val Pro Leu Leu 
    450                 455                 460                 


Leu Tyr Met Pro Gly Lys Val Ala Ala Phe Ala Arg His Met Leu Glu 
465                 470                 475                 480 


Lys Lys Ile Gly Val Val Val Val Gly Phe Pro Ala Thr Pro Leu Ala 
                485                 490                 495     


Glu Ala Arg Ala Arg Phe Cys Val Ser Ala Ala His Thr Arg Glu Met 
            500                 505                 510         


Leu Asp Thr Val Leu Glu Ala Leu Asp Glu Met Gly Asp Leu Leu Gln 
        515                 520                 525             


Leu Lys Tyr Ser Arg His Lys Lys Ser Ala Arg Pro Glu Leu Tyr Asp 
    530                 535                 540                 


Glu Thr Ser Phe Glu Leu Glu Asp 
545                 550         


<210>  4423
<211>  708
<212>  PRT
<213>  Homo sapiens

<400>  4423

Met Lys Asp Met Pro Leu Arg Ile His Val Leu Leu Gly Leu Ala Ile 
1               5                   10                  15      


Thr Thr Leu Val Gln Ala Val Asp Lys Lys Val Asp Cys Pro Arg Leu 
            20                  25                  30          


Cys Thr Cys Glu Ile Arg Pro Trp Phe Thr Pro Arg Ser Ile Tyr Met 
        35                  40                  45              


Glu Ala Ser Thr Val Asp Cys Asn Asp Leu Gly Leu Leu Thr Phe Pro 
    50                  55                  60                  


Ala Arg Leu Pro Ala Asn Thr Gln Ile Leu Leu Leu Gln Thr Asn Asn 
65                  70                  75                  80  


Ile Ala Lys Ile Glu Tyr Ser Thr Asp Phe Pro Val Asn Leu Thr Gly 
                85                  90                  95      


Leu Asp Leu Ser Gln Asn Asn Leu Ser Ser Val Thr Asn Ile Asn Val 
            100                 105                 110         


Lys Lys Met Pro Gln Leu Leu Ser Val Tyr Leu Glu Glu Asn Lys Leu 
        115                 120                 125             


Thr Glu Leu Pro Glu Lys Cys Leu Ser Glu Leu Ser Asn Leu Gln Glu 
    130                 135                 140                 


Leu Tyr Ile Asn His Asn Leu Leu Ser Thr Ile Ser Pro Gly Ala Phe 
145                 150                 155                 160 


Ile Gly Leu His Asn Leu Leu Arg Leu His Leu Asn Ser Asn Arg Leu 
                165                 170                 175     


Gln Met Ile Asn Ser Lys Trp Phe Asp Ala Leu Pro Asn Leu Glu Ile 
            180                 185                 190         


Leu Met Ile Gly Glu Asn Pro Ile Ile Arg Ile Lys Asp Met Asn Phe 
        195                 200                 205             


Lys Pro Leu Ile Asn Leu Arg Ser Leu Val Ile Ala Gly Ile Asn Leu 
    210                 215                 220                 


Thr Glu Ile Pro Asp Asn Ala Leu Val Gly Leu Glu Asn Leu Glu Ser 
225                 230                 235                 240 


Ile Ser Phe Tyr Asp Asn Arg Leu Ile Lys Val Pro His Val Ala Leu 
                245                 250                 255     


Gln Lys Val Val Asn Leu Lys Phe Leu Asp Leu Asn Lys Asn Pro Ile 
            260                 265                 270         


Asn Arg Ile Arg Arg Gly Asp Phe Ser Asn Met Leu His Leu Lys Glu 
        275                 280                 285             


Leu Gly Ile Asn Asn Met Pro Glu Leu Ile Ser Ile Asp Ser Leu Ala 
    290                 295                 300                 


Val Asp Asn Leu Pro Asp Leu Arg Lys Ile Glu Ala Thr Asn Asn Pro 
305                 310                 315                 320 


Arg Leu Ser Tyr Ile His Pro Asn Ala Phe Phe Arg Leu Pro Lys Leu 
                325                 330                 335     


Glu Ser Leu Met Leu Asn Ser Asn Ala Leu Ser Ala Leu Tyr His Gly 
            340                 345                 350         


Thr Ile Glu Ser Leu Pro Asn Leu Lys Glu Ile Ser Ile His Ser Asn 
        355                 360                 365             


Pro Ile Arg Cys Asp Cys Val Ile Arg Trp Met Asn Met Asn Lys Thr 
    370                 375                 380                 


Asn Ile Arg Phe Met Glu Pro Asp Ser Leu Phe Cys Val Asp Pro Pro 
385                 390                 395                 400 


Glu Phe Gln Gly Gln Asn Val Arg Gln Val His Phe Arg Asp Met Met 
                405                 410                 415     


Glu Ile Cys Leu Pro Leu Ile Ala Pro Glu Ser Phe Pro Ser Asn Leu 
            420                 425                 430         


Asn Val Glu Ala Gly Ser Tyr Val Ser Phe His Cys Arg Ala Thr Ala 
        435                 440                 445             


Glu Pro Gln Pro Glu Ile Tyr Trp Ile Thr Pro Ser Gly Gln Lys Leu 
    450                 455                 460                 


Leu Pro Asn Thr Leu Thr Asp Lys Phe Tyr Val His Ser Glu Gly Thr 
465                 470                 475                 480 


Leu Asp Ile Asn Gly Val Thr Pro Lys Glu Gly Gly Leu Tyr Thr Cys 
                485                 490                 495     


Ile Ala Thr Asn Leu Val Gly Ala Asp Leu Lys Ser Val Met Ile Lys 
            500                 505                 510         


Val Asp Gly Ser Phe Pro Gln Asp Asn Asn Gly Ser Leu Asn Ile Lys 
        515                 520                 525             


Ile Arg Asp Ile Gln Ala Asn Ser Val Leu Val Ser Trp Lys Ala Ser 
    530                 535                 540                 


Ser Lys Ile Leu Lys Ser Ser Val Lys Trp Thr Ala Phe Val Lys Thr 
545                 550                 555                 560 


Glu Asn Ser His Ala Ala Gln Ser Ala Arg Ile Pro Ser Asp Val Lys 
                565                 570                 575     


Val Tyr Asn Leu Thr His Leu Asn Pro Ser Thr Glu Tyr Lys Ile Cys 
            580                 585                 590         


Ile Asp Ile Pro Thr Ile Tyr Gln Lys Asn Arg Lys Lys Cys Val Asn 
        595                 600                 605             


Val Thr Thr Lys Gly Leu His Pro Asp Gln Lys Glu Tyr Glu Lys Asn 
    610                 615                 620                 


Asn Thr Thr Thr Leu Met Ala Cys Leu Gly Gly Leu Leu Gly Ile Ile 
625                 630                 635                 640 


Gly Val Ile Cys Leu Ile Ser Cys Leu Ser Pro Glu Met Asn Cys Asp 
                645                 650                 655     


Gly Gly His Ser Tyr Val Arg Asn Tyr Leu Gln Lys Pro Thr Phe Ala 
            660                 665                 670         


Leu Gly Glu Leu Tyr Pro Pro Leu Ile Asn Leu Trp Glu Ala Gly Lys 
        675                 680                 685             


Glu Lys Ser Thr Ser Leu Lys Val Lys Ala Thr Val Ile Gly Leu Pro 
    690                 695                 700                 


Thr Asn Met Ser 
705             


<210>  4424
<211>  678
<212>  PRT
<213>  Homo sapiens

<400>  4424

Met Glu Val Leu Ile Gly Asp Pro Ile Thr Thr Cys Leu Ser Pro Ser 
1               5                   10                  15      


Val Tyr Asp Ile Ile Cys Asn Leu Gly Phe Gln Leu Arg Glu Asn Cys 
            20                  25                  30          


Asp Ile Asn Ser Ile Val Thr Gln Asn Gly Glu Val Cys Trp Lys Thr 
        35                  40                  45              


Ile Thr Asp Cys Val Ser Tyr Thr Glu Ser Glu Gln Gly Leu Asp Tyr 
    50                  55                  60                  


Trp Gly Ser Val Arg Leu Leu Gly Pro Val Cys Glu Ala Val His Ser 
65                  70                  75                  80  


His Phe Leu Ser Leu Thr Lys Gly Gln Phe Glu Ile Arg Tyr Ala Pro 
                85                  90                  95      


Trp Phe Gln Trp Thr Ser Phe Pro Glu Leu Phe Pro Glu Ile Phe Asp 
            100                 105                 110         


Ala Leu Glu Ser Leu Gln Ser Pro Ala Ile Ser Leu Ser Leu Met Lys 
        115                 120                 125             


Leu Thr Ser Cys Leu Glu Arg Ala Leu Gly Asp Val Phe Leu Leu Ile 
    130                 135                 140                 


Gly Lys Glu Cys Pro Phe Leu Leu Arg Asp Leu Leu Ser Ser Glu Glu 
145                 150                 155                 160 


Leu Ala Gln Val Phe Ser Gln Ser Val Met Asn Val Leu Lys Val Phe 
                165                 170                 175     


Val Gly Ser Pro Cys Gly Leu Asn Leu Arg Asn Val Leu Trp His Gly 
            180                 185                 190         


Phe Ala Ser Pro Glu Glu Ile Pro Pro Lys Tyr Cys Ser Met Met Ile 
        195                 200                 205             


Leu Leu Thr Ala Gly Leu Gly Gln Leu Leu Lys Ser Tyr Leu Gln Asn 
    210                 215                 220                 


Thr Lys Leu Thr Leu Ala His Arg Ser Phe Ile Ser Leu Thr Asn Leu 
225                 230                 235                 240 


Glu Asp Leu Ile Val Phe Pro Asp Val Thr Tyr Glu Val Leu Ser Val 
                245                 250                 255     


Leu Glu Glu Val Met Met Lys Ser Ala Phe Ile Leu Lys Ile Met Leu 
            260                 265                 270         


Pro Tyr Trp Glu Val Ala Leu Val Lys Phe Lys Ser His Arg Phe Ala 
        275                 280                 285             


Asp Cys Ala Ile Leu Leu Leu Thr Gln Leu Glu Thr Gly Leu Arg Asn 
    290                 295                 300                 


Val Phe Ala Thr Leu Asn Arg Cys Pro Lys Arg Leu Leu Thr Ala Glu 
305                 310                 315                 320 


Ser Thr Ala Leu Tyr Thr Thr Phe Asp Gln Ile Leu Ala Lys His Leu 
                325                 330                 335     


Asn Asp Gly Lys Ile Asn Gln Leu Pro Leu Phe Leu Gly Glu Pro Ala 
            340                 345                 350         


Met Glu Phe Leu Trp Asp Phe Leu Asn His Gln Glu Gly Pro Arg Ile 
        355                 360                 365             


Arg Asp His Leu Ser His Gly Glu Ile Asn Leu His Glu Phe Ser Lys 
    370                 375                 380                 


Glu Thr Thr Asn Gln Leu Leu Ala Phe Ser Leu Val Leu Leu Leu Arg 
385                 390                 395                 400 


Phe Val Asp Asp Cys Leu Leu Ser Val Phe Lys Glu Lys Ser Ala Val 
                405                 410                 415     


Glu Leu Leu Ile Ser Leu Ala Glu Gly Tyr Ser Ser Arg Cys His Pro 
            420                 425                 430         


Val Phe Gln Leu Lys Lys Gln Val Leu Ser Cys Glu Glu Ser Ile Arg 
        435                 440                 445             


Val Trp Ala Leu Leu Pro Phe Pro Glu Glu Leu Thr Arg Gln Ala Val 
    450                 455                 460                 


Arg Leu Glu Asp Asn Ser Glu Thr Asn Ala Cys His Ser Leu Ile Thr 
465                 470                 475                 480 


Lys Met Thr Asp Glu Leu Tyr His His Met Pro Glu Asn Arg Cys Val 
                485                 490                 495     


Leu Lys Asp Leu Asp Arg Leu Pro Thr Glu Thr Trp Pro Gln Leu Leu 
            500                 505                 510         


Arg Glu Leu Cys Ser Thr Pro Val Pro Thr Leu Phe Cys Pro Arg Ile 
        515                 520                 525             


Val Leu Glu Val Leu Val Val Leu Arg Ser Ile Ser Glu Gln Cys Arg 
    530                 535                 540                 


Arg Val Ser Ser Gln Val Thr Val Ala Ser Glu Leu Arg His Arg Gln 
545                 550                 555                 560 


Trp Val Glu Arg Thr Leu Arg Ser Arg Gln Arg Gln Asn Tyr Leu Arg 
                565                 570                 575     


Met Trp Ser Ser Ile Arg Leu Leu Ser Pro Val Leu Ser Leu Ile Leu 
            580                 585                 590         


Leu Leu Ile Ala Leu Glu Leu Val Asn Ile His Ala Val Cys Gly Lys 
        595                 600                 605             


Asn Ala His Glu Tyr Gln Gln Tyr Leu Lys Phe Val Lys Ser Ile Leu 
    610                 615                 620                 


Gln Tyr Thr Glu Asn Leu Val Ala Tyr Thr Ser Tyr Glu Lys Asn Lys 
625                 630                 635                 640 


Trp Asn Glu Thr Ile Asn Leu Thr His Thr Ala Leu Leu Lys Met Trp 
                645                 650                 655     


Thr Phe Ser Glu Lys Lys Gln Met Leu Ile His Leu Ala Lys Lys Ser 
            660                 665                 670         


Thr Ser Lys Val Leu Leu 
        675             


<210>  4425
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  4425

Met Ser Asn Asn Gly Ala Asp Leu Thr Phe Gly Tyr Ile Ser Cys Phe 
1               5                   10                  15      


Val Ala Ile Leu Leu Phe Gly Ser Asn Phe Val Pro Leu Lys Lys Phe 
            20                  25                  30          


Asp Thr Gly Asp Gly Met Phe Leu Gln Trp Val Leu Cys Ala Ala Ile 
        35                  40                  45              


Trp Leu Val Ala Leu Val Val Asn Leu Ile Leu His Cys Pro Lys Phe 
    50                  55                  60                  


Trp Pro Phe Ala Met Leu Gly Gly Cys Ile Trp Ala Thr Gly Asn Ile 
65                  70                  75                  80  


Ala Val Val Pro Ile Ile Lys Thr Ile Gly Leu Gly Leu Gly Ile Leu 
                85                  90                  95      


Ile Trp Gly Ser Phe Asn Ala Leu Thr Gly Trp Ala Ser Ser Arg Phe 
            100                 105                 110         


Gly Trp Phe Gly Leu Asp Ala Glu Glu Val Ser Asn Pro Leu Leu Asn 
        115                 120                 125             


Tyr Ile Gly Ala Gly Leu Ser Val Val Ser Ala Phe Ile Phe Leu Phe 
    130                 135                 140                 


Ile Lys Ser Glu Ile Pro Asn Asn Thr Cys Ser Met Asp Thr Thr Pro 
145                 150                 155                 160 


Leu Ile Thr Glu His Val Ile Asn Thr Thr Gln Asp Pro Cys Ser Trp 
                165                 170                 175     


Val Asp Lys Leu Ser Thr Val His His Arg Ile Val Gly Cys Ser Leu 
            180                 185                 190         


Ala Val Ile Ser Gly Val Leu Tyr Gly Ser Thr Phe Val Pro Ile Ile 
        195                 200                 205             


Tyr Ile Lys Asp His Ser Lys Arg Asn Asp Ser Ile Tyr Ala Gly Ala 
    210                 215                 220                 


Ser Gln Tyr Asp Leu Asp Tyr Val Phe Ala His Phe Ser Gly Ile Phe 
225                 230                 235                 240 


Leu Thr Ser Thr Val Tyr Phe Leu Ala Tyr Cys Ile Ala Met Lys Asn 
                245                 250                 255     


Ser Pro Lys Leu Tyr Pro Glu Ala Val Leu Pro Gly Phe Leu Ser Gly 
            260                 265                 270         


Val Leu Trp Ala Ile Ala Thr Cys Cys Trp Phe Ile Ala Asn His Ser 
        275                 280                 285             


Leu Ser Ala Val Val Ser Phe Pro Ile Ile Thr Ala Gly Pro Gly Phe 
    290                 295                 300                 


Ile Ala Ala Met Trp Gly Ile Phe Met Phe Lys Glu Ile Lys Gly Leu 
305                 310                 315                 320 


Gln Asn Tyr Leu Leu Met Ile Leu Ala Phe Cys Ile Ile Leu Thr Gly 
                325                 330                 335     


Ala Leu Cys Thr Ala Phe Ser Lys Ile 
            340                 345 


<210>  4426
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  4426

Met Ala Val Val Ser Glu Asp Asp Phe Gln His Ser Ser Asn Ser Thr 
1               5                   10                  15      


Tyr Arg Thr Thr Ser Ser Ser Leu Arg Ala Asp Gln Glu Ala Leu Leu 
            20                  25                  30          


Glu Lys Leu Leu Asp Arg Pro Pro Pro Gly Leu Gln Arg Pro Glu Asp 
        35                  40                  45              


Arg Phe Cys Gly Thr Tyr Ile Ile Phe Phe Ser Leu Gly Ile Gly Ser 
    50                  55                  60                  


Leu Leu Pro Trp Asn Phe Phe Ile Thr Ala Lys Glu Tyr Trp Met Phe 
65                  70                  75                  80  


Lys Leu Arg Asn Ser Ser Ser Pro Ala Thr Gly Glu Asp Pro Glu Gly 
                85                  90                  95      


Ser Asp Ile Leu Asn Tyr Phe Glu Ser Tyr Leu Ala Val Ala Ser Thr 
            100                 105                 110         


Val Pro Ser Met Leu Cys Leu Val Ala Asn Phe Leu Leu Val Asn Arg 
        115                 120                 125             


Val Ala Val His Ile Arg Val Leu Ala Ser Leu Thr Val Ile Leu Ala 
    130                 135                 140                 


Ile Phe Met Val Ile Thr Ala Leu Val Lys Val Asp Thr Ser Ser Trp 
145                 150                 155                 160 


Thr Arg Gly Phe Phe Ala Val Thr Ile Val Cys Met Val Ile Leu Ser 
                165                 170                 175     


Gly Ala Ser Thr Val Phe Ser Ser Ser Ile Tyr Gly Met Thr Gly Ser 
            180                 185                 190         


Phe Pro Met Arg Asn Ser Gln Ala Leu Ile Ser Gly Gly Ala Met Gly 
        195                 200                 205             


Gly Thr Val Ser Ala Val Ala Ser Leu Val Asp Leu Ala Ala Ser Ser 
    210                 215                 220                 


Asp Val Arg Asn Ser Ala Leu Ala Phe Phe Leu Thr Ala Thr Val Phe 
225                 230                 235                 240 


Leu Val Leu Cys Met Gly Leu Tyr Leu Leu Leu Ser Arg Leu Glu Tyr 
                245                 250                 255     


Ala Arg Tyr Tyr Met Arg Pro Val Leu Ala Ala His Val Phe Ser Gly 
            260                 265                 270         


Glu Glu Glu Leu Pro Gln Asp Ser Leu Ser Ala Pro Ser Val Ala Ser 
        275                 280                 285             


Arg Phe Ile Asp Ser His Thr Pro Pro Leu Arg Pro Ile Leu Lys Lys 
    290                 295                 300                 


Thr Ala Ser Leu Gly Phe Cys Val Thr Tyr Val Phe Phe Ile Thr Ser 
305                 310                 315                 320 


Leu Ile Tyr Pro Ala Ile Cys Thr Asn Ile Glu Ser Leu Asn Lys Gly 
                325                 330                 335     


Ser Gly Ser Leu Trp Thr Thr Lys Phe Phe Ile Pro Leu Thr Thr Phe 
            340                 345                 350         


Leu Leu Tyr Asn Phe Ala Asp Leu Cys Gly Arg Gln Leu Thr Ala Trp 
        355                 360                 365             


Ile Gln Val Pro Gly Pro Asn Ser Lys Ala Leu Pro Gly Phe Val Leu 
    370                 375                 380                 


Leu Arg Thr Cys Leu Ile Pro Leu Phe Val Leu Cys Asn Tyr Gln Pro 
385                 390                 395                 400 


Arg Val His Leu Lys Thr Val Val Phe Gln Ser Asp Val Tyr Pro Ala 
                405                 410                 415     


Leu Leu Ser Ser Leu Leu Gly Leu Ser Asn Gly Tyr Leu Ser Thr Leu 
            420                 425                 430         


Ala Leu Leu Tyr Gly Pro Lys Ile Val Pro Arg Glu Leu Ala Glu Ala 
        435                 440                 445             


Thr Gly Val Val Met Ser Phe Tyr Val Cys Leu Gly Leu Thr Leu Gly 
    450                 455                 460                 


Ser Ala Cys Ser Thr Leu Leu Val His Leu Ile 
465                 470                 475 


<210>  4427
<211>  878
<212>  PRT
<213>  Homo sapiens

<400>  4427

Met Asp Leu Asp Lys Pro Ser Val Trp Gly Ser Leu Lys Gln Arg Thr 
1               5                   10                  15      


Arg Pro Leu Leu Ile Asn Leu Ser Lys Lys Lys Val Lys Lys Asn Pro 
            20                  25                  30          


Ser Lys Pro Pro Asp Leu Arg Ala Arg His His Leu Asp Arg Arg Leu 
        35                  40                  45              


Ser Leu Ser Val Pro Asp Leu Leu Glu Ala Glu Ala Leu Ala Pro Glu 
    50                  55                  60                  


Gly Arg Pro Tyr Ser Gly Pro Gln Ser Ser Tyr Thr Ser Val Pro Ser 
65                  70                  75                  80  


Ser Leu Ser Thr Ala Gly Ile Phe Pro Lys Ser Ser Ser Ser Ser Leu 
                85                  90                  95      


Lys Gln Ser Glu Glu Glu Leu Asp Trp Ser Gln Glu Glu Ala Ser His 
            100                 105                 110         


Leu His Val Val Glu Thr Asp Ser Glu Glu Ala Tyr Ala Ser Pro Ala 
        115                 120                 125             


Glu Arg Arg Arg Val Ser Ser Asn Gly Ile Phe Asp Leu Gln Lys Thr 
    130                 135                 140                 


Ser Leu Gly Gly Asp Ala Pro Glu Glu Pro Glu Lys Leu Cys Gly Ser 
145                 150                 155                 160 


Ser Asp Leu Asn Ala Ser Met Thr Ser Gln His Phe Glu Glu Gln Ser 
                165                 170                 175     


Val Pro Gly Glu Ala Ser Asp Gly Leu Ser Asn Leu Pro Ser Pro Phe 
            180                 185                 190         


Ala Tyr Leu Leu Thr Ile His Leu Lys Glu Gly Arg Asn Leu Val Val 
        195                 200                 205             


Arg Asp Arg Cys Gly Thr Ser Asp Pro Tyr Val Lys Phe Lys Leu Asn 
    210                 215                 220                 


Gly Lys Thr Leu Tyr Lys Ser Lys Val Ile Tyr Lys Asn Leu Asn Pro 
225                 230                 235                 240 


Val Trp Asp Glu Ile Val Val Leu Pro Ile Gln Ser Leu Asp Gln Lys 
                245                 250                 255     


Leu Arg Val Lys Val Tyr Asp Arg Asp Leu Thr Thr Ser Asp Phe Met 
            260                 265                 270         


Gly Ser Ala Phe Val Ile Leu Ser Asp Leu Glu Leu Asn Arg Thr Thr 
        275                 280                 285             


Glu His Ile Leu Lys Leu Glu Asp Pro Asn Ser Leu Glu Asp Asp Met 
    290                 295                 300                 


Gly Val Ile Val Leu Asn Leu Asn Leu Val Val Lys Gln Gly Asp Phe 
305                 310                 315                 320 


Lys Arg His Arg Trp Ser Asn Arg Lys Arg Leu Ser Ala Ser Lys Ser 
                325                 330                 335     


Ser Leu Ile Arg Asn Leu Arg Leu Ser Glu Ser Leu Lys Lys Asn Gln 
            340                 345                 350         


Leu Trp Asn Gly Ile Ile Ser Ile Thr Leu Leu Glu Gly Lys Asn Val 
        355                 360                 365             


Ser Gly Gly Ser Met Thr Glu Met Phe Val Gln Leu Lys Leu Gly Asp 
    370                 375                 380                 


Gln Arg Tyr Lys Ser Lys Thr Leu Cys Lys Ser Ala Asn Pro Gln Trp 
385                 390                 395                 400 


Gln Glu Gln Phe Asp Phe His Tyr Phe Ser Asp Arg Met Gly Ile Leu 
                405                 410                 415     


Asp Ile Glu Val Trp Gly Lys Asp Asn Lys Lys His Glu Glu Arg Leu 
            420                 425                 430         


Gly Thr Cys Lys Val Asp Ile Ser Ala Leu Pro Leu Lys Gln Ala Asn 
        435                 440                 445             


Cys Leu Glu Leu Pro Leu Asp Ser Cys Leu Gly Ala Leu Leu Met Leu 
    450                 455                 460                 


Val Thr Leu Thr Pro Cys Ala Gly Val Ser Val Ser Asp Leu Cys Val 
465                 470                 475                 480 


Cys Pro Leu Ala Asp Leu Ser Glu Arg Lys Gln Ile Thr Gln Arg Tyr 
                485                 490                 495     


Cys Leu Gln Asn Ser Leu Lys Asp Val Lys Asp Val Gly Ile Leu Gln 
            500                 505                 510         


Val Lys Val Leu Lys Ala Ala Asp Leu Leu Ala Ala Asp Phe Ser Gly 
        515                 520                 525             


Lys Ser Asp Pro Phe Cys Leu Leu Glu Leu Gly Asn Asp Arg Leu Gln 
    530                 535                 540                 


Thr His Thr Val Tyr Lys Asn Leu Asn Pro Glu Trp Asn Lys Val Phe 
545                 550                 555                 560 


Thr Phe Pro Ile Lys Asp Ile His Asp Val Leu Glu Val Thr Val Phe 
                565                 570                 575     


Asp Glu Asp Gly Asp Lys Pro Pro Asp Phe Leu Gly Lys Val Ala Ile 
            580                 585                 590         


Pro Leu Leu Ser Ile Arg Asp Gly Gln Pro Asn Cys Tyr Val Leu Lys 
        595                 600                 605             


Asn Lys Asp Leu Glu Gln Ala Phe Lys Gly Val Ile Tyr Leu Glu Met 
    610                 615                 620                 


Asp Leu Ile Tyr Asn Pro Val Lys Ala Ser Ile Arg Thr Phe Thr Pro 
625                 630                 635                 640 


Arg Glu Lys Arg Phe Val Glu Asp Ser Arg Lys Leu Ser Lys Lys Ile 
                645                 650                 655     


Leu Ser Arg Asp Val Asp Arg Val Lys Arg Ile Thr Met Ala Ile Trp 
            660                 665                 670         


Asn Thr Met Gln Phe Leu Lys Ser Cys Phe Gln Trp Glu Ser Thr Leu 
        675                 680                 685             


Arg Ser Thr Ile Ala Phe Ala Val Phe Leu Ile Thr Val Trp Asn Phe 
    690                 695                 700                 


Glu Leu Tyr Met Ile Pro Leu Ala Leu Leu Leu Ile Phe Val Tyr Asn 
705                 710                 715                 720 


Phe Ile Arg Pro Val Lys Gly Lys Val Ser Ser Ile Gln Asp Ser Gln 
                725                 730                 735     


Glu Ser Thr Asp Ile Asp Asp Glu Glu Asp Glu Asp Asp Lys Glu Ser 
            740                 745                 750         


Glu Lys Lys Gly Leu Ile Glu Arg Ile Tyr Met Val Gln Asp Ile Val 
        755                 760                 765             


Ser Thr Val Gln Asn Val Leu Glu Glu Ile Ala Ser Phe Gly Glu Arg 
    770                 775                 780                 


Ile Lys Asn Thr Phe Asn Trp Thr Val Pro Phe Leu Ser Ser Leu Ala 
785                 790                 795                 800 


Cys Leu Ile Leu Ala Ala Ala Thr Ile Ile Leu Tyr Phe Ile Pro Leu 
                805                 810                 815     


Arg Tyr Ile Ile Leu Ile Trp Gly Ile Asn Lys Phe Thr Lys Lys Leu 
            820                 825                 830         


Arg Asn Pro Tyr Ser Ile Asp Asn Asn Glu Leu Leu Asp Phe Leu Ser 
        835                 840                 845             


Arg Val Pro Ser Asp Val Gln Lys Val Gln Tyr Ala Glu Leu Lys Leu 
    850                 855                 860                 


Cys Ser Ser His Ser Pro Leu Arg Lys Lys Arg Ser Ala Leu 
865                 870                 875             


<210>  4428
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  4428

Met Pro Pro Ala Gln Gly Tyr Glu Phe Ala Ala Ala Lys Gly Pro Arg 
1               5                   10                  15      


Asp Glu Leu Gly Pro Ser Phe Pro Met Ala Ser Pro Pro Gly Leu Glu 
            20                  25                  30          


Leu Lys Thr Leu Ser Asn Gly Pro Gln Ala Pro Arg Arg Ser Ala Pro 
        35                  40                  45              


Leu Gly Pro Val Ala Pro Thr Arg Glu Gly Val Glu Asn Ala Cys Phe 
    50                  55                  60                  


Ser Ser Glu Glu His Glu Thr His Phe Gln Asn Pro Gly Asn Thr Arg 
65                  70                  75                  80  


Leu Gly Ser Ser Pro Ser Pro Pro Gly Gly Val Ser Ser Leu Pro Arg 
                85                  90                  95      


Ser Gln Arg Asp Asp Leu Ser Leu His Ser Glu Glu Gly Pro Ala Leu 
            100                 105                 110         


Glu Pro Val Ser Arg Pro Val Asp Tyr Gly Phe Val Ser Ala Leu Val 
        115                 120                 125             


Phe Leu Val Ser Gly Ile Leu Leu Val Val Thr Ala Tyr Ala Ile Pro 
    130                 135                 140                 


Arg Glu Ala Arg Val Asn Pro Asp Thr Val Thr Ala Arg Glu Met Glu 
145                 150                 155                 160 


Arg Leu Glu Met Tyr Tyr Ala Arg Leu Gly Ser His Leu Asp Arg Cys 
                165                 170                 175     


Ile Ile Ala Gly Leu Gly Leu Leu Thr Val Gly Gly Met Leu Leu Ser 
            180                 185                 190         


Val Leu Leu Met Val Ser Leu Cys Lys Gly Glu Leu Tyr Arg Arg Arg 
        195                 200                 205             


Thr Phe Val Pro Gly Lys Gly Ser Arg Lys Thr Tyr Gly Ser Ile Asn 
    210                 215                 220                 


Leu Arg Met Arg Gln Leu Asn Gly Asp Gly Gly Gln Ala Leu Val Glu 
225                 230                 235                 240 


Asn Glu Val Val Gln Val Ser Glu Thr Ser His Thr Leu Gln Arg Ser 
                245                 250                 255     


<210>  4429
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  4429

Met Leu Leu Ser Leu Val Leu His Thr Tyr Ser Met Arg Tyr Leu Leu 
1               5                   10                  15      


Pro Ser Val Val Leu Leu Gly Thr Ala Pro Thr Tyr Val Leu Ala Trp 
            20                  25                  30          


Gly Val Trp Arg Leu Leu Ser Ala Phe Leu Pro Ala Arg Phe Tyr Gln 
        35                  40                  45              


Ala Leu Asp Asp Arg Leu Tyr Cys Val Tyr Gln Ser Met Val Leu Phe 
    50                  55                  60                  


Phe Phe Glu Asn Tyr Thr Gly Val Gln Ile Leu Leu Tyr Gly Asp Leu 
65                  70                  75                  80  


Pro Lys Asn Lys Glu Asn Ile Ile Tyr Leu Ala Asn His Gln Ser Thr 
                85                  90                  95      


Val Asp Trp Ile Val Ala Asp Ile Leu Ala Ile Arg Gln Asn Ala Leu 
            100                 105                 110         


Gly His Val Arg Tyr Val Leu Lys Glu Gly Leu Lys Trp Leu Pro Leu 
        115                 120                 125             


Tyr Gly Cys Tyr Phe Ala Gln His Gly Gly Ile Tyr Val Lys Arg Ser 
    130                 135                 140                 


Ala Lys Phe Asn Glu Lys Glu Met Arg Asn Lys Leu Gln Ser Tyr Val 
145                 150                 155                 160 


Asp Ala Gly Thr Pro Met Tyr Leu Val Ile Phe Pro Glu Gly Thr Arg 
                165                 170                 175     


Tyr Asn Pro Glu Gln Thr Lys Val Leu Ser Ala Ser Gln Ala Phe Ala 
            180                 185                 190         


Ala Gln Arg Gly Leu Ala Val Leu Lys His Val Leu Thr Pro Arg Ile 
        195                 200                 205             


Lys Ala Thr His Val Ala Phe Asp Cys Met Lys Asn Tyr Leu Asp Ala 
    210                 215                 220                 


Ile Tyr Asp Val Thr Val Val Tyr Glu Gly Lys Asp Asp Gly Gly Gln 
225                 230                 235                 240 


Arg Arg Glu Ser Pro Thr Met Thr Glu Phe Leu Cys Lys Glu Cys Pro 
                245                 250                 255     


Lys Ile His Ile His Ile Asp Arg Ile Asp Lys Lys Asp Val Pro Glu 
            260                 265                 270         


Glu Gln Glu His Met Arg Arg Trp Leu His Glu Arg Phe Glu Ile Lys 
        275                 280                 285             


Asp Lys Met Leu Ile Glu Phe Tyr Glu Ser Pro Asp Pro Glu Arg Arg 
    290                 295                 300                 


Lys Arg Phe Pro Gly Lys Ser Val Asn Ser Lys Leu Ser Ile Lys Lys 
305                 310                 315                 320 


Thr Leu Pro Ser Met Leu Ile Leu Ser Gly Leu Thr Ala Gly Met Leu 
                325                 330                 335     


Met Thr Asp Ala Gly Arg Lys Leu Tyr Val Asn Thr Trp Ile Tyr Gly 
            340                 345                 350         


Thr Leu Leu Gly Cys Leu Trp Val Thr Ile Lys Ala 
        355                 360                 


<210>  4430
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  4430

Met Ala Pro Ala Ala Asp Arg Glu Gly Tyr Trp Gly Pro Thr Thr Ser 
1               5                   10                  15      


Thr Leu Asp Trp Cys Glu Glu Asn Tyr Ser Val Thr Trp Tyr Ile Ala 
            20                  25                  30          


Glu Phe Trp Asn Thr Val Ser Asn Leu Ile Met Ile Ile Pro Pro Met 
        35                  40                  45              


Phe Gly Ala Val Gln Ser Val Arg Asp Gly Leu Glu Lys Arg Tyr Ile 
    50                  55                  60                  


Ala Ser Tyr Leu Ala Leu Thr Val Val Gly Met Gly Ser Trp Cys Phe 
65                  70                  75                  80  


His Met Thr Leu Lys Tyr Glu Met Gln Leu Leu Asp Glu Leu Pro Met 
                85                  90                  95      


Ile Tyr Ser Cys Cys Ile Phe Val Tyr Cys Met Phe Glu Cys Phe Lys 
            100                 105                 110         


Ile Lys Asn Ser Val Asn Tyr His Leu Leu Phe Thr Leu Val Leu Phe 
        115                 120                 125             


Ser Leu Ile Val Thr Thr Val Tyr Leu Lys Val Lys Glu Pro Ile Phe 
    130                 135                 140                 


His Gln Val Met Tyr Gly Met Leu Val Phe Thr Leu Val Leu Arg Ser 
145                 150                 155                 160 


Ile Tyr Ile Val Thr Trp Val Tyr Pro Trp Leu Arg Gly Leu Gly Tyr 
                165                 170                 175     


Thr Ser Leu Gly Ile Phe Leu Leu Gly Phe Leu Phe Trp Asn Ile Asp 
            180                 185                 190         


Asn Ile Phe Cys Glu Ser Leu Arg Asn Phe Arg Lys Lys Val Pro Pro 
        195                 200                 205             


Ile Ile Gly Ile Thr Thr Gln Phe His Ala Trp Trp His Ile Leu Thr 
    210                 215                 220                 


Gly Leu Gly Ser Tyr Leu His Ile Leu Phe Ser Leu Tyr Thr Arg Thr 
225                 230                 235                 240 


Leu Tyr Leu Arg Tyr Arg Pro Lys Val Lys Phe Leu Phe Gly Ile Trp 
                245                 250                 255     


Pro Val Ile Leu Phe Glu Pro Leu Arg Lys His 
            260                 265         


<210>  4431
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  4431

Met Leu Cys Phe Leu Arg Gly Met Ala Phe Val Pro Phe Leu Leu Val 
1               5                   10                  15      


Thr Trp Ser Ser Ala Ala Phe Ile Ile Ser Tyr Val Val Ala Val Leu 
            20                  25                  30          


Ser Gly His Val Asn Pro Phe Leu Pro Tyr Ile Ser Asp Thr Gly Thr 
        35                  40                  45              


Thr Pro Pro Glu Ser Gly Ile Phe Gly Phe Met Ile Asn Phe Ser Ala 
    50                  55                  60                  


Phe Leu Gly Ala Ala Thr Met Tyr Thr Arg Tyr Lys Ile Val Gln Lys 
65                  70                  75                  80  


Gln Asn Gln Thr Cys Tyr Phe Ser Thr Pro Val Phe Asn Leu Val Ser 
                85                  90                  95      


Leu Val Leu Gly Leu Val Gly Cys Phe Gly Met Gly Ile Val Ala Asn 
            100                 105                 110         


Phe Gln Glu Leu Ala Val Pro Val Val His Asp Gly Gly Ala Leu Leu 
        115                 120                 125             


Ala Phe Val Cys Gly Val Val Tyr Thr Leu Leu Gln Ser Ile Ile Ser 
    130                 135                 140                 


Tyr Lys Ser Cys Pro Gln Trp Asn Ser Leu Ser Thr Cys His Ile Arg 
145                 150                 155                 160 


Met Val Ile Ser Ala Val Ser Cys Ala Ala Val Ile Pro Met Ile Val 
                165                 170                 175     


Cys Ala Ser Leu Ile Ser Ile Thr Lys Leu Glu Trp Asn Pro Arg Glu 
            180                 185                 190         


Lys Asp Tyr Val Tyr His Val Val Ser Ala Ile Cys Glu Trp Thr Val 
        195                 200                 205             


Ala Phe Gly Phe Ile Phe Tyr Phe Leu Thr Phe Ile Gln Asp Phe Gln 
    210                 215                 220                 


Ser Val Thr Leu Arg Ile Ser Thr Glu Ile Asn Gly Asp Ile 
225                 230                 235             


<210>  4432
<211>  532
<212>  PRT
<213>  Homo sapiens

<400>  4432

Met Met Met Val Arg Arg Gly Leu Leu Ala Trp Ile Ser Arg Val Val 
1               5                   10                  15      


Val Leu Leu Val Leu Leu Cys Cys Ala Ile Ser Val Leu Tyr Met Leu 
            20                  25                  30          


Ala Cys Thr Pro Lys Gly Asp Glu Glu Gln Leu Ala Leu Pro Arg Ala 
        35                  40                  45              


Asn Ser Pro Thr Gly Lys Glu Gly Tyr Gln Ala Val Leu Gln Glu Trp 
    50                  55                  60                  


Glu Glu Gln His Arg Asn Tyr Val Ser Ser Leu Lys Arg Gln Ile Ala 
65                  70                  75                  80  


Gln Leu Lys Glu Glu Leu Gln Glu Arg Ser Glu Gln Leu Arg Asn Gly 
                85                  90                  95      


Gln Tyr Gln Ala Ser Asp Ala Ala Gly Leu Gly Leu Asp Arg Ser Pro 
            100                 105                 110         


Pro Glu Lys Thr Gln Ala Asp Leu Leu Ala Phe Leu His Ser Gln Val 
        115                 120                 125             


Asp Lys Ala Glu Val Asn Ala Gly Val Lys Leu Ala Thr Glu Tyr Ala 
    130                 135                 140                 


Ala Val Pro Phe Asp Ser Phe Thr Leu Gln Lys Val Tyr Gln Leu Glu 
145                 150                 155                 160 


Thr Gly Leu Thr Arg His Pro Glu Glu Lys Pro Val Arg Lys Asp Lys 
                165                 170                 175     


Arg Asp Glu Leu Val Glu Ala Ile Glu Ser Ala Leu Glu Thr Leu Asn 
            180                 185                 190         


Ser Pro Ala Glu Asn Ser Pro Asn His Arg Pro Tyr Thr Ala Ser Asp 
        195                 200                 205             


Phe Ile Glu Gly Ile Tyr Arg Thr Glu Arg Asp Lys Gly Thr Leu Tyr 
    210                 215                 220                 


Glu Leu Thr Phe Lys Gly Asp His Lys His Glu Phe Lys Arg Leu Ile 
225                 230                 235                 240 


Leu Phe Arg Pro Phe Gly Pro Ile Met Lys Val Lys Asn Glu Lys Leu 
                245                 250                 255     


Asn Met Ala Asn Thr Leu Ile Asn Val Ile Val Pro Leu Ala Lys Arg 
            260                 265                 270         


Val Asp Lys Phe Arg Gln Phe Met Gln Asn Phe Arg Glu Met Cys Ile 
        275                 280                 285             


Glu Gln Asp Gly Arg Val His Leu Thr Val Val Tyr Phe Gly Lys Glu 
    290                 295                 300                 


Glu Ile Asn Glu Val Lys Gly Ile Leu Glu Asn Thr Ser Lys Ala Ala 
305                 310                 315                 320 


Asn Phe Arg Asn Phe Thr Phe Ile Gln Leu Asn Gly Glu Phe Ser Arg 
                325                 330                 335     


Gly Lys Gly Leu Asp Val Gly Ala Arg Phe Trp Lys Gly Ser Asn Val 
            340                 345                 350         


Leu Leu Phe Phe Cys Asp Val Asp Ile Tyr Phe Thr Ser Glu Phe Leu 
        355                 360                 365             


Asn Thr Cys Arg Leu Asn Thr Gln Pro Gly Lys Lys Val Phe Tyr Pro 
    370                 375                 380                 


Val Leu Phe Ser Gln Tyr Asn Pro Gly Ile Ile Tyr Gly His His Asp 
385                 390                 395                 400 


Ala Val Pro Pro Leu Glu Gln Gln Leu Val Ile Lys Lys Glu Thr Gly 
                405                 410                 415     


Phe Trp Arg Asp Phe Gly Phe Gly Met Thr Cys Gln Tyr Arg Ser Asp 
            420                 425                 430         


Phe Ile Asn Ile Gly Gly Phe Asp Leu Asp Ile Lys Gly Trp Gly Gly 
        435                 440                 445             


Glu Asp Val His Leu Tyr Arg Lys Tyr Leu His Ser Asn Leu Ile Val 
    450                 455                 460                 


Val Arg Thr Pro Val Arg Gly Leu Phe His Leu Trp His Glu Lys Arg 
465                 470                 475                 480 


Cys Met Asp Glu Leu Thr Pro Glu Gln Tyr Lys Met Cys Met Gln Ser 
                485                 490                 495     


Lys Ala Met Asn Glu Ala Ser His Gly Gln Leu Gly Met Leu Val Phe 
            500                 505                 510         


Arg His Glu Ile Glu Ala His Leu Arg Lys Gln Lys Gln Lys Thr Ser 
        515                 520                 525             


Ser Lys Lys Thr 
    530         


<210>  4433
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  4433

Met Asn Gly Arg Val Asp Tyr Leu Val Thr Glu Glu Glu Ile Asn Leu 
1               5                   10                  15      


Thr Arg Gly Pro Ser Gly Leu Gly Phe Asn Ile Val Gly Gly Thr Asp 
            20                  25                  30          


Gln Gln Tyr Val Ser Asn Asp Ser Gly Ile Tyr Val Ser Arg Ile Lys 
        35                  40                  45              


Glu Asn Gly Ala Ala Ala Leu Asp Gly Arg Leu Gln Glu Gly Asp Lys 
    50                  55                  60                  


Ile Leu Ser Val Asn Gly Gln Asp Leu Lys Asn Leu Leu His Gln Asp 
65                  70                  75                  80  


Ala Val Asp Leu Phe Arg Asn Ala Gly Tyr Ala Val Ser Leu Arg Val 
                85                  90                  95      


Gln His Arg Leu Gln Val Gln Asn Gly Pro Ile Gly His Arg Gly Glu 
            100                 105                 110         


Gly Asp Pro Ser Gly Ile Pro Ile Phe Met Val Leu Val Pro Val Phe 
        115                 120                 125             


Ala Leu Thr Met Val Ala Ala Trp Ala Phe Met Arg Tyr Arg Gln Gln 
    130                 135                 140                 


Leu 
145 


<210>  4434
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  4434

Met Gly Lys Ser Leu Ser His Leu Pro Leu His Ser Ser Lys Glu Asp 
1               5                   10                  15      


Ala Tyr Asp Gly Val Thr Ser Glu Asn Met Arg Asn Gly Leu Val Asn 
            20                  25                  30          


Ser Glu Val His Asn Glu Asp Gly Arg Asn Gly Asp Val Ser Gln Phe 
        35                  40                  45              


Pro Tyr Val Glu Phe Thr Gly Arg Asp Ser Val Thr Cys Pro Thr Cys 
    50                  55                  60                  


Gln Gly Thr Gly Arg Ile Pro Arg Gly Gln Glu Asn Gln Leu Val Ala 
65                  70                  75                  80  


Leu Ile Pro Tyr Ser Asp Gln Arg Leu Arg Pro Arg Arg Thr Lys Leu 
                85                  90                  95      


Tyr Val Met Ala Ser Val Phe Val Cys Leu Leu Leu Ser Gly Leu Ala 
            100                 105                 110         


Val Phe Phe Leu Phe Pro Arg Ser Ile Asp Val Lys Tyr Ile Gly Val 
        115                 120                 125             


Lys Ser Ala Tyr Val Ser Tyr Asp Val Gln Lys Arg Thr Ile Tyr Leu 
    130                 135                 140                 


Asn Ile Thr Asn Thr Leu Asn Ile Thr Asn Asn Asn Tyr Tyr Ser Val 
145                 150                 155                 160 


Glu Val Glu Asn Ile Thr Ala Gln Val Gln Phe Ser Lys Thr Val Ile 
                165                 170                 175     


Gly Lys Ala Arg Leu Asn Asn Ile Thr Ile Ile Gly Pro Leu Asp Met 
            180                 185                 190         


Lys Gln Ile Asp Tyr Thr Val Pro Thr Val Ile Ala Glu Glu Met Ser 
        195                 200                 205             


Tyr Met Tyr Asp Phe Cys Thr Leu Ile Ser Ile Lys Val His Asn Ile 
    210                 215                 220                 


Val Leu Met Met Gln Val Thr Val Thr Thr Thr Tyr Phe Gly His Ser 
225                 230                 235                 240 


Glu Gln Ile Ser Gln Glu Arg Tyr Gln Tyr Val Asp Cys Gly Arg Asn 
                245                 250                 255     


Thr Thr Tyr Gln Leu Gly Gln Ser Glu Tyr Leu Asn Val Leu Gln Pro 
            260                 265                 270         


Gln Gln 
        


<210>  4435
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  4435

Met Asp Asp Phe Ile Ser Ile Ser Leu Leu Ser Leu Ala Met Leu Val 
1               5                   10                  15      


Gly Cys Tyr Val Ala Gly Ile Ile Pro Leu Ala Val Asn Phe Ser Glu 
            20                  25                  30          


Glu Arg Leu Lys Leu Val Thr Val Leu Gly Ala Gly Leu Leu Cys Gly 
        35                  40                  45              


Thr Ala Leu Ala Val Ile Val Pro Glu Gly Val His Ala Leu Tyr Glu 
    50                  55                  60                  


Asp Ile Leu Glu Gly Lys His His Gln Ala Ser Glu Thr His Asn Val 
65                  70                  75                  80  


Ile Ala Ser Asp Lys Ala Ala Glu Lys Ser Val Val His Glu His Glu 
                85                  90                  95      


His Ser His Asp His Thr Gln Leu His Ala Tyr Ile Gly Val Ser Leu 
            100                 105                 110         


Val Leu Gly Phe Val Phe Met Leu Leu Val Asp Gln Ile Gly Asn Ser 
        115                 120                 125             


His Val His Ser Thr Asp Asp Pro Glu Ala Ala Arg Ser Ser Asn Ser 
    130                 135                 140                 


Lys Ile Thr Thr Thr Leu Gly Leu Val Val His Ala Ala Ala Asp Gly 
145                 150                 155                 160 


Val Ala Leu Gly Ala Ala Ala Ser Thr Ser Gln Thr Ser Val Gln Leu 
                165                 170                 175     


Ile Val Phe Val Ala Ile Met Leu His Lys Ala Pro Ala Ala Phe Gly 
            180                 185                 190         


Leu Val Ser Phe Leu Met His Ala Gly Leu Glu Arg Asn Arg Ile Arg 
        195                 200                 205             


Lys His Leu Leu Val Phe Ala Leu Ala Ala Pro Val Met Ser Met Val 
    210                 215                 220                 


Thr Tyr Leu Gly Leu Ser Lys Ser Ser Lys Glu Ala Leu Ser Glu Val 
225                 230                 235                 240 


Asn Ala Thr Gly Val Ala Met Leu Phe Ser Ala Gly Thr Phe Leu Tyr 
                245                 250                 255     


Val Ala Thr Val His Val Leu Pro Glu Val Gly Gly Ile Gly His Ser 
            260                 265                 270         


His Lys Pro Asp Ala Thr Gly Gly Arg Gly Leu Ser Arg Leu Glu Val 
        275                 280                 285             


Ala Ala Leu Val Leu Gly Cys Leu Ile Pro Leu Ile Leu Ser Val Gly 
    290                 295                 300                 


His Gln His 
305         


<210>  4436
<211>  1336
<212>  PRT
<213>  Homo sapiens

<400>  4436

Met Ala Thr Glu Ile Gly Ser Pro Pro Arg Phe Phe His Met Pro Arg 
1               5                   10                  15      


Phe Gln His Gln Ala Pro Arg Gln Leu Phe Tyr Lys Arg Pro Asp Phe 
            20                  25                  30          


Ala Gln Gln Gln Ala Met Gln Gln Leu Thr Phe Asp Gly Lys Arg Met 
        35                  40                  45              


Arg Lys Ala Val Asn Arg Lys Thr Ile Asp Tyr Asn Pro Ser Val Ile 
    50                  55                  60                  


Lys Tyr Leu Glu Asn Arg Ile Trp Gln Arg Asp Gln Arg Asp Met Arg 
65                  70                  75                  80  


Ala Ile Gln Pro Asp Ala Gly Tyr Tyr Asn Asp Leu Val Pro Pro Ile 
                85                  90                  95      


Gly Met Leu Asn Asn Pro Met Asn Ala Val Thr Thr Lys Phe Val Arg 
            100                 105                 110         


Thr Ser Thr Asn Lys Val Lys Cys Pro Val Phe Val Val Arg Trp Thr 
        115                 120                 125             


Pro Glu Gly Arg Arg Leu Val Thr Gly Ala Ser Ser Gly Glu Phe Thr 
    130                 135                 140                 


Leu Trp Asn Gly Leu Thr Phe Asn Phe Glu Thr Ile Leu Gln Ala His 
145                 150                 155                 160 


Asp Ser Pro Val Arg Ala Met Thr Trp Ser His Asn Asp Met Trp Met 
                165                 170                 175     


Leu Thr Ala Asp His Gly Gly Tyr Val Lys Tyr Trp Gln Ser Asn Met 
            180                 185                 190         


Asn Asn Val Lys Met Phe Gln Ala His Lys Glu Ala Ile Arg Glu Ala 
        195                 200                 205             


Ser Phe Ser Pro Thr Asp Asn Lys Phe Ala Thr Cys Ser Asp Asp Gly 
    210                 215                 220                 


Thr Val Arg Ile Trp Asp Phe Leu Arg Cys His Glu Glu Arg Ile Leu 
225                 230                 235                 240 


Arg Gly His Gly Ala Asp Val Lys Cys Val Asp Trp His Pro Thr Lys 
                245                 250                 255     


Gly Leu Val Val Ser Gly Ser Lys Asp Ser Gln Gln Pro Ile Lys Phe 
            260                 265                 270         


Trp Asp Pro Lys Thr Gly Gln Ser Leu Ala Thr Leu His Ala His Lys 
        275                 280                 285             


Asn Thr Val Met Glu Val Lys Leu Asn Leu Asn Gly Asn Trp Leu Leu 
    290                 295                 300                 


Thr Ala Ser Arg Asp His Leu Cys Lys Leu Phe Asp Ile Arg Asn Leu 
305                 310                 315                 320 


Lys Glu Glu Leu Gln Val Phe Arg Gly His Lys Lys Glu Ala Thr Ala 
                325                 330                 335     


Val Ala Trp His Pro Val His Glu Gly Leu Phe Ala Ser Gly Gly Ser 
            340                 345                 350         


Asp Gly Ser Leu Leu Phe Trp His Val Gly Val Glu Lys Glu Val Gly 
        355                 360                 365             


Gly Met Glu Met Ala His Glu Gly Met Ile Trp Ser Leu Ala Trp His 
    370                 375                 380                 


Pro Leu Gly His Ile Leu Cys Ser Gly Ser Asn Asp His Thr Ser Lys 
385                 390                 395                 400 


Phe Trp Thr Arg Asn Arg Pro Gly Asp Lys Met Arg Asp Arg Tyr Asn 
                405                 410                 415     


Leu Asn Leu Leu Pro Gly Met Ser Glu Asp Gly Val Glu Tyr Asp Asp 
            420                 425                 430         


Leu Glu Pro Asn Ser Leu Ala Val Ile Pro Gly Met Gly Ile Pro Glu 
        435                 440                 445             


Gln Leu Lys Leu Ala Met Glu Gln Glu Gln Met Gly Lys Asp Glu Ser 
    450                 455                 460                 


Asn Glu Ile Glu Met Thr Ile Pro Gly Leu Asp Trp Gly Met Glu Glu 
465                 470                 475                 480 


Val Met Gln Lys Asp Gln Lys Lys Val Pro Gln Lys Lys Val Pro Tyr 
                485                 490                 495     


Ala Lys Pro Ile Pro Ala Gln Phe Gln Gln Ala Trp Met Gln Asn Lys 
            500                 505                 510         


Val Pro Ile Pro Ala Pro Asn Glu Val Leu Asn Asp Arg Lys Glu Asp 
        515                 520                 525             


Ile Lys Leu Glu Glu Lys Lys Lys Thr Gln Ala Glu Ile Glu Gln Glu 
    530                 535                 540                 


Met Ala Thr Leu Gln Tyr Thr Asn Pro Gln Leu Leu Glu Gln Leu Lys 
545                 550                 555                 560 


Ile Glu Arg Leu Ala Gln Lys Gln Val Glu Gln Ile Gln Pro Pro Pro 
                565                 570                 575     


Ser Ser Gly Thr Pro Leu Leu Gly Pro Gln Pro Phe Pro Gly Gln Gly 
            580                 585                 590         


Pro Met Ser Gln Ile Pro Gln Gly Phe Gln Gln Pro His Pro Ser Gln 
        595                 600                 605             


Gln Met Pro Met Asn Met Ala Gln Met Gly Pro Pro Gly Pro Gln Gly 
    610                 615                 620                 


Gln Phe Arg Pro Pro Gly Pro Gln Gly Gln Met Gly Pro Gln Gly Pro 
625                 630                 635                 640 


Pro Leu His Gln Gly Gly Gly Gly Pro Gln Gly Phe Met Gly Pro Gln 
                645                 650                 655     


Gly Pro Gln Gly Pro Pro Gln Gly Leu Pro Arg Pro Gln Asp Met His 
            660                 665                 670         


Gly Pro Gln Gly Met Gln Arg His Pro Gly Pro His Gly Pro Leu Gly 
        675                 680                 685             


Pro Gln Gly Pro Pro Gly Pro Gln Gly Ser Ser Gly Pro Gln Gly His 
    690                 695                 700                 


Met Gly Pro Gln Gly Pro Pro Gly Pro Gln Gly His Ile Gly Pro Gln 
705                 710                 715                 720 


Gly Pro Pro Gly Pro Gln Gly His Leu Gly Pro Gln Gly Pro Pro Gly 
                725                 730                 735     


Thr Gln Gly Met Gln Gly Pro Pro Gly Pro Arg Gly Met Gln Gly Pro 
            740                 745                 750         


Pro His Pro His Gly Ile Gln Gly Gly Pro Gly Ser Gln Gly Ile Gln 
        755                 760                 765             


Gly Pro Val Ser Gln Gly Pro Leu Met Gly Leu Asn Pro Arg Gly Met 
    770                 775                 780                 


Gln Gly Pro Pro Gly Pro Arg Glu Asn Gln Gly Pro Ala Pro Gln Gly 
785                 790                 795                 800 


Met Ile Met Gly His Pro Pro Gln Glu Met Arg Gly Pro His Pro Pro 
                805                 810                 815     


Gly Gly Leu Leu Gly His Gly Pro Gln Glu Met Arg Gly Pro Gln Glu 
            820                 825                 830         


Ile Arg Gly Met Gln Gly Pro Pro Pro Gln Gly Ser Met Leu Gly Pro 
        835                 840                 845             


Pro Gln Glu Leu Arg Gly Pro Pro Gly Ser Gln Ser Gln Gln Gly Pro 
    850                 855                 860                 


Pro Gln Gly Ser Leu Gly Pro Pro Pro Gln Gly Gly Met Gln Gly Pro 
865                 870                 875                 880 


Pro Gly Pro Gln Gly Gln Gln Asn Pro Ala Arg Gly Pro His Pro Ser 
                885                 890                 895     


Gln Gly Pro Ile Pro Phe Gln Gln Gln Lys Thr Pro Leu Leu Gly Asp 
            900                 905                 910         


Gly Pro Arg Ala Pro Phe Asn Gln Glu Gly Gln Ser Thr Gly Pro Pro 
        915                 920                 925             


Pro Leu Ile Pro Gly Leu Gly Gln Gln Gly Ala Gln Gly Arg Ile Pro 
    930                 935                 940                 


Pro Leu Asn Pro Gly Gln Gly Pro Gly Pro Asn Lys Gly Asp Ser Arg 
945                 950                 955                 960 


Gly Pro Pro Asn His His Met Gly Pro Met Ser Glu Arg Arg His Glu 
                965                 970                 975     


Gln Ser Gly Gly Pro Glu His Gly Pro Glu Arg Gly Pro Phe Arg Gly 
            980                 985                 990         


Gly Gln Asp Cys Arg Gly Pro Pro  Asp Arg Arg Gly Pro  His Pro Asp 
        995                 1000                 1005             


Phe Pro  Asp Asp Phe Ser Arg  Pro Asp Asp Phe His  Pro Asp Lys 
    1010                 1015                 1020             


Arg Phe  Gly His Arg Leu Arg  Glu Phe Glu Gly Arg  Gly Gly Pro 
    1025                 1030                 1035             


Leu Pro  Gln Glu Glu Lys Trp  Arg Arg Gly Gly Pro  Gly Pro Pro 
    1040                 1045                 1050             


Phe Pro  Pro Asp His Arg Glu  Phe Ser Glu Gly Asp  Gly Arg Gly 
    1055                 1060                 1065             


Ala Ala  Arg Gly Pro Pro Gly  Ala Trp Glu Gly Arg  Arg Pro Gly 
    1070                 1075                 1080             


Asp Glu  Arg Phe Pro Arg Asp  Pro Glu Asp Pro Arg  Phe Arg Gly 
    1085                 1090                 1095             


Arg Arg  Glu Glu Ser Phe Arg  Arg Gly Ala Pro Pro  Arg His Glu 
    1100                 1105                 1110             


Gly Arg  Ala Pro Pro Arg Gly  Arg Asp Gly Phe Pro  Gly Pro Glu 
    1115                 1120                 1125             


Asp Phe  Gly Pro Glu Glu Asn  Phe Asp Ala Ser Glu  Glu Ala Ala 
    1130                 1135                 1140             


Arg Gly  Arg Asp Leu Arg Gly  Arg Gly Arg Gly Thr  Pro Arg Gly 
    1145                 1150                 1155             


Gly Arg  Lys Gly Leu Leu Pro  Thr Pro Asp Glu Phe  Pro Arg Phe 
    1160                 1165                 1170             


Glu Gly  Gly Arg Lys Pro Asp  Ser Trp Asp Gly Asn  Arg Glu Pro 
    1175                 1180                 1185             


Gly Pro  Gly His Glu His Phe  Arg Asp Thr Pro Arg  Pro Asp His 
    1190                 1195                 1200             


Pro Pro  His Asp Gly His Ser  Pro Ala Ser Arg Glu  Arg Ser Ser 
    1205                 1210                 1215             


Ser Leu  Gln Gly Met Asp Met  Ala Ser Leu Pro Pro  Arg Lys Arg 
    1220                 1225                 1230             


Pro Trp  His Asp Gly Pro Gly  Thr Ser Glu His Arg  Glu Met Glu 
    1235                 1240                 1245             


Ala Pro  Gly Gly Pro Ser Glu  Asp Arg Gly Gly Lys  Gly Arg Gly 
    1250                 1255                 1260             


Gly Pro  Gly Pro Ala Gln Arg  Val Pro Lys Ser Gly  Arg Ser Ser 
    1265                 1270                 1275             


Ser Leu  Asp Gly Glu His His  Asp Gly Tyr His Arg  Asp Glu Pro 
    1280                 1285                 1290             


Phe Gly  Gly Pro Pro Gly Ser  Gly Thr Pro Ser Arg  Gly Gly Arg 
    1295                 1300                 1305             


Ser Gly  Ser Asn Trp Gly Arg  Gly Ser Asn Met Asn  Ser Gly Pro 
    1310                 1315                 1320             


Pro Arg  Arg Gly Ala Ser Arg  Gly Gly Gly Arg Gly  Arg 
    1325                 1330                 1335     


<210>  4437
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  4437

Met Asn Arg Ala Pro Leu Lys Arg Ser Arg Ile Leu His Met Ala Leu 
1               5                   10                  15      


Thr Gly Ala Ser Asp Pro Ser Ala Glu Ala Glu Ala Asn Gly Glu Lys 
            20                  25                  30          


Pro Phe Leu Leu Arg Ala Leu Gln Ile Ala Leu Val Val Ser Leu Tyr 
        35                  40                  45              


Trp Val Thr Ser Ile Ser Met Val Phe Leu Asn Lys Tyr Leu Leu Asp 
    50                  55                  60                  


Ser Pro Ser Leu Arg Leu Asp Thr Pro Ile Phe Val Thr Phe Tyr Gln 
65                  70                  75                  80  


Cys Leu Val Thr Thr Leu Leu Cys Lys Gly Leu Ser Ala Leu Ala Ala 
                85                  90                  95      


Cys Cys Pro Gly Ala Val Asp Phe Pro Ser Leu Arg Leu Asp Leu Arg 
            100                 105                 110         


Val Ala Arg Ser Val Leu Pro Leu Ser Val Val Phe Ile Gly Met Ile 
        115                 120                 125             


Thr Phe Asn Asn Leu Cys Leu Lys Tyr Val Gly Val Ala Phe Tyr Asn 
    130                 135                 140                 


Val Gly Arg Ser Leu Thr Thr Val Phe Asn Val Leu Leu Ser Tyr Leu 
145                 150                 155                 160 


Leu Leu Lys Gln Thr Thr Ser Phe Tyr Ala Leu Leu Thr Cys Gly Ile 
                165                 170                 175     


Ile Ile Gly Gly Phe Trp Leu Gly Val Asp Gln Glu Gly Ala Glu Gly 
            180                 185                 190         


Thr Leu Ser Trp Leu Gly Thr Val Phe Gly Val Leu Ala Ser Leu Cys 
        195                 200                 205             


Val Ser Leu Asn Ala Ile Tyr Thr Thr Lys Val Leu Pro Ala Val Asp 
    210                 215                 220                 


Gly Ser Ile Trp Arg Leu Thr Phe Tyr Asn Asn Val Asn Ala Cys Ile 
225                 230                 235                 240 


Leu Phe Leu Pro Leu Leu Leu Leu Leu Gly Glu Leu Gln Ala Leu Arg 
                245                 250                 255     


Asp Phe Ala Gln Leu Gly Ser Ala His Phe Trp Gly Met Met Thr Leu 
            260                 265                 270         


Gly Gly Leu Phe Gly Phe Ala Ile Gly Tyr Val Thr Gly Leu Gln Ile 
        275                 280                 285             


Lys Phe Thr Ser Pro Leu Thr His Asn Val Ser Gly Thr Ala Lys Ala 
    290                 295                 300                 


Cys Ala Gln Thr Val Leu Ala Val Leu Tyr Tyr Glu Glu Thr Lys Ser 
305                 310                 315                 320 


Phe Leu Trp Trp Thr Ser Asn Met Met Val Leu Gly Gly Ser Ser Ala 
                325                 330                 335     


Tyr Thr Trp Val Arg Gly Trp Glu Met Lys Lys Thr Pro Glu Glu Pro 
            340                 345                 350         


Ser Pro Lys Asp Ser Glu Lys Ser Ala Met Gly Val 
        355                 360                 


<210>  4438
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  4438

Met Gly Val Asn Leu Leu Ala Ala Asn Thr His Asn Thr Ser Met His 
1               5                   10                  15      


Met Thr Gly Ser Gly Ile Tyr Ala Pro Glu Ala Val Lys Val Tyr His 
            20                  25                  30          


Tyr Asp Met Glu Thr Glu Ser Gly Gln Leu Leu Leu Ser Glu Leu Lys 
        35                  40                  45              


Ser Arg Pro Arg Arg Glu Pro Thr Tyr Pro Ala Ala Val Asp Trp His 
    50                  55                  60                  


Ala Tyr Ala Ser Ser Val Lys Pro Phe Ser Ser Glu Gln Ser Asp Phe 
65                  70                  75                  80  


Leu Gly Met Ile Tyr Phe Asp Glu Phe Thr Phe Thr Lys Leu Lys Arg 
                85                  90                  95      


Asn Thr Gly Asn Tyr Thr Ala Cys Gln Lys Asp Leu Cys Cys His Leu 
            100                 105                 110         


Thr Tyr Lys Met Ser Glu Lys Arg Thr Asp Glu Ile Tyr Ala Leu Gly 
        115                 120                 125             


Ala Phe Asp Gly Leu His Thr Val Glu Gly Gln Tyr Tyr Leu Gln Ile 
    130                 135                 140                 


Cys Ala Leu Leu Lys Cys Gln Thr Thr Asp Leu Glu Thr Cys Gly Glu 
145                 150                 155                 160 


Pro Val Gly Ser Ala Phe Thr Lys Phe Glu Asp Phe Ser Leu Ser Gly 
                165                 170                 175     


Thr Phe Gly Thr Arg Tyr Val Phe Pro Gln Ile Ile Leu Ser Gly Ser 
            180                 185                 190         


Gln Leu Ala Pro Glu Arg His Tyr Glu Ile Ser Arg Asp Gly Arg Leu 
        195                 200                 205             


Arg Ser Arg Ser Gly Ala Pro Leu Pro Val Leu Val Met Ala Leu Tyr 
    210                 215                 220                 


Gly Arg Val Phe Glu Lys Asp Pro Pro Arg Leu Gly Gln Gly Ser Gly 
225                 230                 235                 240 


Lys Phe Gln 
            


<210>  4439
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  4439

Met Pro Ala Phe Asn Arg Leu Phe Pro Leu Ala Ser Leu Val Leu Ile 
1               5                   10                  15      


Tyr Trp Val Ser Val Cys Phe Pro Val Cys Val Glu Val Pro Ser Glu 
            20                  25                  30          


Thr Glu Ala Val Gln Gly Asn Pro Met Lys Leu Arg Cys Ile Ser Cys 
        35                  40                  45              


Met Lys Arg Glu Glu Val Glu Ala Thr Thr Val Val Glu Trp Phe Tyr 
    50                  55                  60                  


Arg Pro Glu Gly Gly Lys Asp Phe Leu Ile Tyr Glu Tyr Arg Asn Gly 
65                  70                  75                  80  


His Gln Glu Val Glu Ser Pro Phe Gln Gly Arg Leu Gln Trp Asn Gly 
                85                  90                  95      


Ser Lys Asp Leu Gln Asp Val Ser Ile Thr Val Leu Asn Val Thr Leu 
            100                 105                 110         


Asn Asp Ser Gly Leu Tyr Thr Cys Asn Val Ser Arg Glu Phe Glu Phe 
        115                 120                 125             


Glu Ala His Arg Pro Phe Val Lys Thr Thr Arg Leu Ile Pro Leu Arg 
    130                 135                 140                 


Val Thr Glu Glu Ala Gly Glu Asp Phe Thr Ser Val Val Ser Glu Ile 
145                 150                 155                 160 


Met Met Tyr Ile Leu Leu Val Phe Leu Thr Leu Trp Leu Leu Ile Glu 
                165                 170                 175     


Met Ile Tyr Cys Tyr Arg Lys Val Ser Lys Ala Glu Glu Ala Ala Gln 
            180                 185                 190         


Glu Asn Ala Ser Asp Tyr Leu Ala Ile Pro Ser Glu Asn Lys Glu Asn 
        195                 200                 205             


Ser Ala Val Pro Val Glu Glu 
    210                 215 


<210>  4440
<211>  5412
<212>  PRT
<213>  Homo sapiens

<400>  4440

Met Lys Gly Ala Arg Trp Arg Arg Val Pro Trp Val Ser Leu Ser Cys 
1               5                   10                  15      


Leu Cys Leu Cys Leu Leu Pro His Val Val Pro Gly Thr Thr Glu Asp 
            20                  25                  30          


Thr Leu Ile Thr Gly Ser Lys Thr Ala Ala Pro Val Thr Ser Thr Gly 
        35                  40                  45              


Ser Thr Thr Ala Thr Leu Glu Gly Gln Ser Thr Ala Ala Ser Ser Arg 
    50                  55                  60                  


Thr Ser Asn Gln Asp Ile Ser Ala Ser Ser Gln Asn His Gln Thr Lys 
65                  70                  75                  80  


Ser Thr Glu Thr Thr Ser Lys Ala Gln Thr Asp Thr Leu Thr Gln Met 
                85                  90                  95      


Met Thr Ser Thr Leu Phe Ser Ser Pro Ser Val His Asn Val Met Glu 
            100                 105                 110         


Thr Ala Pro Pro Asp Glu Met Thr Thr Ser Phe Pro Ser Ser Val Thr 
        115                 120                 125             


Asn Thr Leu Met Met Thr Ser Lys Thr Ile Thr Met Thr Thr Ser Thr 
    130                 135                 140                 


Asp Ser Thr Leu Gly Asn Thr Glu Glu Thr Ser Thr Ala Gly Thr Glu 
145                 150                 155                 160 


Ser Ser Thr Pro Val Thr Ser Ala Val Ser Ile Thr Ala Gly Gln Glu 
                165                 170                 175     


Gly Gln Ser Arg Thr Thr Ser Trp Arg Thr Ser Ile Gln Asp Thr Ser 
            180                 185                 190         


Ala Ser Ser Gln Asn His Trp Thr Arg Ser Thr Gln Thr Thr Arg Glu 
        195                 200                 205             


Ser Gln Thr Ser Thr Leu Thr His Arg Thr Thr Ser Thr Pro Ser Phe 
    210                 215                 220                 


Ser Pro Ser Val His Asn Val Thr Gly Thr Val Ser Gln Lys Thr Ser 
225                 230                 235                 240 


Pro Ser Gly Glu Thr Ala Thr Ser Ser Leu Cys Ser Val Thr Asn Thr 
                245                 250                 255     


Ser Met Met Thr Ser Glu Lys Ile Thr Val Thr Thr Ser Thr Gly Ser 
            260                 265                 270         


Thr Leu Gly Asn Pro Gly Glu Thr Ser Ser Val Pro Val Thr Gly Ser 
        275                 280                 285             


Leu Met Pro Val Thr Ser Ala Ala Leu Val Thr Phe Asp Pro Glu Gly 
    290                 295                 300                 


Gln Ser Pro Ala Thr Phe Ser Arg Thr Ser Thr Gln Asp Thr Thr Ala 
305                 310                 315                 320 


Phe Ser Lys Asn His Gln Thr Gln Ser Val Glu Thr Thr Arg Val Ser 
                325                 330                 335     


Gln Ile Asn Thr Leu Asn Thr Leu Thr Pro Val Thr Thr Ser Thr Val 
            340                 345                 350         


Leu Ser Ser Pro Ser Gly Phe Asn Pro Ser Gly Thr Val Ser Gln Glu 
        355                 360                 365             


Thr Phe Pro Ser Gly Glu Thr Thr Thr Ser Ser Pro Ser Ser Val Ser 
    370                 375                 380                 


Asn Thr Phe Leu Val Thr Ser Lys Val Phe Arg Met Pro Thr Ser Arg 
385                 390                 395                 400 


Asp Ser Thr Leu Gly Asn Thr Glu Glu Thr Ser Leu Ser Val Ser Gly 
                405                 410                 415     


Thr Ile Ser Ala Ile Thr Ser Lys Val Ser Thr Ile Trp Trp Ser Asp 
            420                 425                 430         


Thr Leu Ser Thr Ala Leu Ser Pro Ser Ser Leu Pro Pro Lys Ile Ser 
        435                 440                 445             


Thr Ala Phe His Thr Gln Gln Ser Glu Gly Ala Glu Thr Thr Gly Arg 
    450                 455                 460                 


Pro His Glu Arg Ser Ser Phe Ser Pro Gly Val Ser Gln Glu Ile Phe 
465                 470                 475                 480 


Thr Leu His Glu Thr Thr Thr Trp Pro Ser Ser Phe Ser Ser Lys Gly 
                485                 490                 495     


His Thr Thr Trp Ser Gln Thr Glu Leu Pro Ser Thr Ser Thr Gly Ala 
            500                 505                 510         


Ala Thr Arg Leu Val Thr Gly Asn Pro Ser Thr Gly Thr Ala Gly Thr 
        515                 520                 525             


Ile Pro Arg Val Pro Ser Lys Val Ser Ala Ile Gly Glu Pro Gly Glu 
    530                 535                 540                 


Pro Thr Thr Tyr Ser Ser His Ser Thr Thr Leu Pro Lys Thr Thr Gly 
545                 550                 555                 560 


Ala Gly Ala Gln Thr Gln Trp Thr Gln Glu Thr Gly Thr Thr Gly Glu 
                565                 570                 575     


Ala Leu Leu Ser Ser Pro Ser Tyr Ser Val Thr Gln Met Ile Lys Thr 
            580                 585                 590         


Ala Thr Ser Pro Ser Ser Ser Pro Met Leu Asp Arg His Thr Ser Gln 
        595                 600                 605             


Gln Ile Thr Thr Ala Pro Ser Thr Asn His Ser Thr Ile His Ser Thr 
    610                 615                 620                 


Ser Thr Ser Pro Gln Glu Ser Pro Ala Val Ser Gln Arg Gly His Thr 
625                 630                 635                 640 


Gln Ala Pro Gln Thr Thr Gln Glu Ser Gln Thr Thr Arg Ser Val Ser 
                645                 650                 655     


Pro Met Thr Asp Thr Lys Thr Val Thr Thr Pro Gly Ser Ser Phe Thr 
            660                 665                 670         


Ala Ser Gly His Ser Pro Ser Glu Ile Val Pro Gln Asp Ala Pro Thr 
        675                 680                 685             


Ile Ser Ala Ala Thr Thr Phe Ala Pro Ala Pro Thr Gly Asp Gly His 
    690                 695                 700                 


Thr Thr Gln Ala Pro Thr Thr Ala Leu Gln Ala Ala Pro Ser Ser His 
705                 710                 715                 720 


Asp Ala Thr Leu Gly Pro Ser Gly Gly Thr Ser Leu Ser Lys Thr Gly 
                725                 730                 735     


Ala Leu Thr Leu Ala Asn Ser Val Val Ser Thr Pro Gly Gly Pro Glu 
            740                 745                 750         


Gly Gln Trp Thr Ser Ala Ser Ala Ser Thr Ser Pro Asp Thr Ala Ala 
        755                 760                 765             


Ala Met Thr His Thr His Gln Ala Glu Ser Thr Glu Ala Ser Gly Gln 
    770                 775                 780                 


Thr Gln Thr Ser Glu Pro Ala Ser Ser Gly Ser Arg Thr Thr Ser Ala 
785                 790                 795                 800 


Gly Thr Ala Thr Pro Ser Ser Ser Gly Ala Ser Gly Thr Thr Pro Ser 
                805                 810                 815     


Gly Ser Glu Gly Ile Ser Thr Ser Gly Glu Thr Thr Arg Phe Ser Ser 
            820                 825                 830         


Asn Pro Ser Arg Asp Ser His Thr Thr Gln Ser Thr Thr Glu Leu Leu 
        835                 840                 845             


Ser Ala Ser Ala Ser His Gly Ala Ile Pro Val Ser Thr Gly Met Ala 
    850                 855                 860                 


Ser Ser Ile Val Pro Gly Thr Phe His Pro Thr Leu Ser Glu Ala Ser 
865                 870                 875                 880 


Thr Ala Gly Arg Pro Thr Gly Gln Ser Ser Pro Thr Ser Pro Ser Ala 
                885                 890                 895     


Ser Pro Gln Glu Thr Ala Ala Ile Ser Arg Met Ala Gln Thr Gln Arg 
            900                 905                 910         


Thr Arg Thr Ser Arg Gly Ser Asp Thr Ile Ser Leu Ala Ser Gln Ala 
        915                 920                 925             


Thr Asp Thr Phe Ser Thr Val Pro Pro Thr Pro Pro Ser Ile Thr Ser 
    930                 935                 940                 


Thr Gly Leu Thr Ser Pro Gln Thr Glu Thr His Thr Leu Ser Pro Ser 
945                 950                 955                 960 


Gly Ser Gly Lys Thr Phe Thr Thr Ala Leu Ile Ser Asn Ala Thr Pro 
                965                 970                 975     


Leu Pro Val Thr Tyr Ala Ser Ser Ala Ser Thr Gly His Thr Thr Pro 
            980                 985                 990         


Leu His Val Thr Asp Ala Ser Ser  Val Ser Thr Gly His  Ala Thr Pro 
        995                 1000                 1005             


Leu Pro  Val Thr Ser Pro Ser  Ser Val Ser Thr Gly  His Thr Thr 
    1010                 1015                 1020             


Pro Leu  Pro Val Thr Asp Thr  Ser Ser Glu Ser Thr  Gly His Val 
    1025                 1030                 1035             


Thr Pro  Leu Pro Val Thr Ser  Phe Ser Ser Ala Ser  Thr Gly Asp 
    1040                 1045                 1050             


Ser Thr  Pro Leu Pro Val Thr  Asp Thr Ser Ser Ala  Ser Thr Gly 
    1055                 1060                 1065             


His Val  Thr Pro Leu Pro Val  Thr Ser Leu Ser Ser  Ala Ser Thr 
    1070                 1075                 1080             


Gly Asp  Thr Thr Pro Leu Pro  Val Thr Asp Thr Ser  Ser Ala Ser 
    1085                 1090                 1095             


Thr Gly  His Ala Thr Ser Leu  Pro Val Thr Asp Thr  Ser Ser Val 
    1100                 1105                 1110             


Ser Thr  Gly His Thr Thr Pro  Leu Pro Val Thr Asp  Thr Ser Ser 
    1115                 1120                 1125             


Ala Ser  Thr Gly His Ala Thr  Ser Leu Pro Val Thr  Asp Thr Ser 
    1130                 1135                 1140             


Ser Val  Ser Thr Gly His Thr  Thr Pro Leu His Val  Thr Asp Ala 
    1145                 1150                 1155             


Ser Ser  Ala Ser Thr Gly Gln  Ala Thr Pro Leu Pro  Val Thr Ser 
    1160                 1165                 1170             


Leu Ser  Ser Val Ser Thr Gly  Asp Thr Thr Pro Leu  Pro Val Thr 
    1175                 1180                 1185             


Ser Pro  Ser Ser Ala Ser Thr  Gly His Ala Thr Pro  Leu Leu Val 
    1190                 1195                 1200             


Thr Asp  Thr Ser Ser Ala Ser  Thr Gly His Ala Thr  Pro Leu Pro 
    1205                 1210                 1215             


Val Thr  Asp Ala Ser Ser Val  Ser Thr Asp His Ala  Thr Ser Leu 
    1220                 1225                 1230             


Pro Val  Thr Ile Pro Ser Ala  Ala Ser Thr Gly His  Thr Thr Pro 
    1235                 1240                 1245             


Leu Pro  Val Thr Asp Thr Ser  Ser Ala Ser Thr Gly  Gln Ala Thr 
    1250                 1255                 1260             


Ser Leu  Leu Val Thr Asp Thr  Ser Ser Val Ser Thr  Gly Asp Thr 
    1265                 1270                 1275             


Thr Pro  Leu Pro Val Thr Ser  Thr Ser Ser Ala Ser  Thr Gly His 
    1280                 1285                 1290             


Val Thr  Pro Leu His Val Thr  Ser Pro Ser Ser Ala  Ser Thr Gly 
    1295                 1300                 1305             


His Ala  Thr Pro Leu Pro Val  Thr Ser Leu Ser Ser  Ala Ser Thr 
    1310                 1315                 1320             


Gly Asp  Thr Met Pro Leu Pro  Val Thr Ser Pro Ser  Ser Ala Ser 
    1325                 1330                 1335             


Thr Gly  Asp Thr Thr Pro Leu  Pro Val Thr Asp Ala  Ser Ser Val 
    1340                 1345                 1350             


Ser Thr  Gly His Thr Thr Pro  Leu His Val Thr Asp  Ala Ser Ser 
    1355                 1360                 1365             


Ala Ser  Thr Gly Gln Ala Thr  Pro Leu Pro Val Thr  Ser Leu Ser 
    1370                 1375                 1380             


Ser Val  Ser Thr Gly Asp Thr  Thr Pro Leu Pro Val  Thr Ser Pro 
    1385                 1390                 1395             


Ser Ser  Ala Ser Thr Gly His  Ala Thr Pro Leu Leu  Val Thr Asp 
    1400                 1405                 1410             


Thr Ser  Ser Ala Ser Thr Gly  His Ala Thr Pro Leu  Pro Val Thr 
    1415                 1420                 1425             


Asp Ala  Ser Ser Val Ser Thr  Asp His Ala Thr Ser  Leu Pro Val 
    1430                 1435                 1440             


Thr Ile  Pro Ser Ala Ala Ser  Thr Gly His Thr Thr  Pro Leu Pro 
    1445                 1450                 1455             


Val Thr  Asp Thr Ser Ser Ala  Ser Thr Gly Gln Ala  Thr Ser Leu 
    1460                 1465                 1470             


Leu Val  Thr Asp Thr Ser Ser  Val Ser Thr Gly Asp  Thr Thr Pro 
    1475                 1480                 1485             


Leu Pro  Val Thr Ser Thr Ser  Ser Ala Ser Thr Gly  His Val Thr 
    1490                 1495                 1500             


Pro Leu  His Val Thr Ser Pro  Ser Ser Ala Ser Thr  Gly His Ala 
    1505                 1510                 1515             


Thr Pro  Leu Pro Val Thr Ser  Leu Ser Ser Ala Ser  Thr Gly Asp 
    1520                 1525                 1530             


Thr Met  Pro Leu Pro Val Thr  Ser Pro Ser Ser Ala  Ser Thr Gly 
    1535                 1540                 1545             


Asp Thr  Thr Pro Leu Pro Val  Thr Asp Ala Ser Ser  Val Ser Thr 
    1550                 1555                 1560             


Gly His  Thr Thr Pro Leu Pro  Val Thr Ser Pro Ser  Ser Ala Ser 
    1565                 1570                 1575             


Thr Gly  His Thr Thr Pro Leu  Pro Val Thr Asp Thr  Ser Ser Ala 
    1580                 1585                 1590             


Ser Lys  Gly Asp Thr Thr Pro  Leu Pro Val Thr Ser  Pro Ser Ser 
    1595                 1600                 1605             


Ala Ser  Thr Gly His Thr Thr  Pro Leu Pro Val Thr  Asp Thr Ser 
    1610                 1615                 1620             


Ser Ala  Ser Thr Gly Asp Thr  Thr Pro Leu Pro Val  Thr Asn Ala 
    1625                 1630                 1635             


Ser Ser  Leu Ser Thr Gly His  Ala Thr Pro Leu His  Val Thr Ser 
    1640                 1645                 1650             


Pro Ser  Ser Ala Ser Thr Gly  His Ala Thr Pro Leu  Pro Val Thr 
    1655                 1660                 1665             


Ser Thr  Ser Ser Ala Ser Thr  Gly His Ala Thr Pro  Leu Pro Val 
    1670                 1675                 1680             


Thr Gly  Leu Ser Ser Ala Thr  Thr Asp Asp Thr Thr  Arg Leu Pro 
    1685                 1690                 1695             


Val Thr  Asp Val Ser Ser Ala  Ser Thr Gly Gln Ala  Thr Pro Leu 
    1700                 1705                 1710             


Pro Val  Thr Ser Leu Ser Ser  Val Ser Thr Gly Asp  Thr Thr Pro 
    1715                 1720                 1725             


Leu Pro  Val Thr Ser Pro Ser  Ser Ala Ser Thr Gly  His Ala Ser 
    1730                 1735                 1740             


Pro Leu  Leu Val Thr Asp Ala  Ser Ser Ala Ser Thr  Gly Gln Ala 
    1745                 1750                 1755             


Thr Pro  Leu Pro Val Thr Asp  Thr Ser Ser Val Ser  Thr Ala His 
    1760                 1765                 1770             


Ala Thr  Pro Leu Pro Val Thr  Gly Leu Ser Ser Ala  Ser Thr Asp 
    1775                 1780                 1785             


Asp Thr  Thr Arg Leu Pro Val  Thr Asp Val Ser Ser  Ala Ser Thr 
    1790                 1795                 1800             


Gly Gln  Ala Ile Pro Leu Pro  Val Thr Ser Pro Ser  Ser Ala Ser 
    1805                 1810                 1815             


Thr Gly  Asp Thr Thr Pro Leu  Pro Val Thr Asp Ala  Ser Ser Ala 
    1820                 1825                 1830             


Ser Thr  Gly Asp Thr Thr Ser  Leu Pro Val Thr Ile  Pro Ser Ser 
    1835                 1840                 1845             


Ala Ser  Ser Gly His Thr Thr  Ser Leu Pro Val Thr  Asp Ala Ser 
    1850                 1855                 1860             


Ser Val  Ser Thr Gly His Ala  Thr Ser Leu Leu Val  Thr Asp Ala 
    1865                 1870                 1875             


Ser Ser  Val Ser Thr Gly Asp  Thr Thr Pro Leu Pro  Val Thr Asp 
    1880                 1885                 1890             


Thr Asn  Ser Ala Ser Thr Gly  Asp Thr Thr Pro Leu  His Val Thr 
    1895                 1900                 1905             


Asp Ala  Ser Ser Val Ser Thr  Gly His Ala Thr Ser  Leu Pro Val 
    1910                 1915                 1920             


Thr Ser  Leu Ser Ser Ala Ser  Thr Gly Asp Thr Thr  Pro Leu Pro 
    1925                 1930                 1935             


Val Thr  Ser Pro Ser Ser Ala  Ser Ser Gly His Thr  Thr Pro Leu 
    1940                 1945                 1950             


Pro Val  Thr Asp Ala Ser Ser  Val Pro Thr Gly His  Ala Thr Ser 
    1955                 1960                 1965             


Leu Pro  Val Thr Asp Ala Ser  Ser Val Ser Thr Gly  His Ala Thr 
    1970                 1975                 1980             


Pro Leu  Pro Val Thr Asp Ala  Ser Ser Val Ser Thr  Gly His Ala 
    1985                 1990                 1995             


Thr Pro  Leu Pro Val Thr Asp  Thr Ser Ser Val Ser  Thr Gly Gln 
    2000                 2005                 2010             


Ala Thr  Pro Leu Pro Val Thr  Ser Leu Ser Ser Ala  Ser Thr Gly 
    2015                 2020                 2025             


Asp Thr  Thr Pro Leu Pro Val  Thr Asp Thr Ser Ser  Ala Ser Thr 
    2030                 2035                 2040             


Gly Gln  Asp Thr Pro Leu Pro  Val Thr Ser Leu Ser  Ser Val Ser 
    2045                 2050                 2055             


Thr Gly  Asp Thr Thr Pro Leu  Pro Val Thr Asn Pro  Ser Ser Ala 
    2060                 2065                 2070             


Ser Thr  Gly His Ala Thr Pro  Leu Leu Val Thr Asp  Ala Ser Ser 
    2075                 2080                 2085             


Ile Ser  Thr Gly His Ala Thr  Ser Leu Leu Val Thr  Asp Ala Ser 
    2090                 2095                 2100             


Ser Val  Ser Thr Gly His Ala  Thr Ala Leu His Asp  Thr Asp Ala 
    2105                 2110                 2115             


Ser Ser  Leu Ser Thr Gly Asp  Thr Thr Pro Leu Pro  Val Thr Ser 
    2120                 2125                 2130             


Pro Ser  Ser Thr Ser Thr Gly  Asp Thr Thr Pro Leu  Pro Val Thr 
    2135                 2140                 2145             


Glu Thr  Ser Ser Val Ser Thr  Gly His Ala Thr Ser  Leu Pro Val 
    2150                 2155                 2160             


Thr Asp  Thr Ser Ser Ala Ser  Thr Gly His Ala Thr  Ser Leu Pro 
    2165                 2170                 2175             


Val Thr  Asp Thr Ser Ser Ala  Ser Thr Gly His Ala  Thr Pro Leu 
    2180                 2185                 2190             


Pro Val  Thr Asp Thr Ser Ser  Ala Ser Thr Gly Gln  Ala Thr Pro 
    2195                 2200                 2205             


Leu Pro  Val Thr Ser Pro Ser  Ser Ala Ser Thr Gly  His Ala Ile 
    2210                 2215                 2220             


Pro Leu  Leu Val Thr Asp Thr  Ser Ser Ala Ser Thr  Gly Gln Ala 
    2225                 2230                 2235             


Thr Pro  Leu Pro Val Thr Ser  Leu Ser Ser Ala Ser  Thr Gly Asp 
    2240                 2245                 2250             


Thr Thr  Pro Leu Pro Val Thr  Asp Ala Ser Ser Val  Ser Thr Gly 
    2255                 2260                 2265             


His Ala  Thr Ser Leu Pro Val  Thr Ser Leu Ser Ser  Val Ser Thr 
    2270                 2275                 2280             


Gly Asp  Thr Thr Pro Leu Pro  Val Thr Ser Pro Ser  Ser Ala Ser 
    2285                 2290                 2295             


Thr Gly  His Ala Thr Pro Leu  His Val Thr Asp Ala  Ser Ser Ala 
    2300                 2305                 2310             


Ser Thr  Gly His Ala Thr Pro  Leu Pro Val Thr Ser  Leu Ser Ser 
    2315                 2320                 2325             


Ala Ser  Thr Gly Asp Thr Thr  Pro Leu Pro Val Thr  Ser Pro Ser 
    2330                 2335                 2340             


Ser Ala  Ser Thr Gly His Ala  Thr Pro Leu His Val  Thr Asp Ala 
    2345                 2350                 2355             


Ser Ser  Val Ser Thr Gly Asp  Thr Thr Pro Leu Pro  Val Thr Ser 
    2360                 2365                 2370             


Ser Ser  Ser Ala Ser Ser Gly  His Thr Thr Pro Leu  Pro Val Thr 
    2375                 2380                 2385             


Asp Ala  Ser Ser Ala Ser Thr  Gly Asp Thr Thr Pro  Leu Pro Val 
    2390                 2395                 2400             


Thr Asp  Thr Ser Ser Ala Ser  Thr Gly His Ala Thr  His Leu Pro 
    2405                 2410                 2415             


Val Thr  Gly Leu Ser Ser Ala  Ser Thr Gly Asp Thr  Thr Arg Leu 
    2420                 2425                 2430             


Pro Val  Thr Asn Val Ser Ser  Ala Ser Thr Gly His  Ala Thr Pro 
    2435                 2440                 2445             


Leu Pro  Val Thr Ser Thr Ser  Ser Ala Ser Thr Gly  Asp Thr Thr 
    2450                 2455                 2460             


Pro Leu  Pro Gly Thr Asp Thr  Ser Ser Val Ser Thr  Gly His Thr 
    2465                 2470                 2475             


Thr Pro  Leu Leu Val Thr Asp  Ala Ser Ser Val Ser  Thr Gly Asp 
    2480                 2485                 2490             


Thr Thr  Arg Leu Pro Val Thr  Ser Pro Ser Ser Ala  Ser Thr Gly 
    2495                 2500                 2505             


His Thr  Thr Pro Leu Pro Val  Thr Asp Thr Pro Ser  Ala Ser Thr 
    2510                 2515                 2520             


Gly Asp  Thr Thr Pro Leu Pro  Val Thr Asn Ala Ser  Ser Leu Ser 
    2525                 2530                 2535             


Thr Arg  His Ala Thr Ser Leu  His Val Thr Ser Pro  Ser Ser Ala 
    2540                 2545                 2550             


Ser Thr  Gly His Ala Thr Ser  Leu Pro Val Thr Asp  Thr Ser Ala 
    2555                 2560                 2565             


Ala Ser  Thr Gly His Ala Thr  Pro Leu Pro Val Thr  Ser Thr Ser 
    2570                 2575                 2580             


Ser Ala  Ser Thr Gly Asp Thr  Thr Pro Leu Pro Val  Thr Asp Thr 
    2585                 2590                 2595             


Tyr Ser  Ala Ser Thr Gly Gln  Ala Thr Pro Leu Pro  Val Thr Ser 
    2600                 2605                 2610             


Leu Ser  Ser Val Ser Thr Gly  Asp Thr Thr Pro Leu  Pro Val Thr 
    2615                 2620                 2625             


Ser Pro  Ser Ser Ala Ser Thr  Gly His Ala Thr Pro  Leu Leu Val 
    2630                 2635                 2640             


Thr Asp  Ala Ser Ser Ala Ser  Thr Gly Gln Ala Thr  Pro Leu Pro 
    2645                 2650                 2655             


Val Thr  Ser Leu Ser Ser Val  Ser Thr Gly Asp Thr  Thr Pro Leu 
    2660                 2665                 2670             


Pro Val  Thr Ser Pro Ser Ser  Ala Ser Thr Gly His  Ala Thr Ser 
    2675                 2680                 2685             


Leu Pro  Val Thr Asp Thr Ser  Ser Ala Ser Thr Gly  Asp Thr Thr 
    2690                 2695                 2700             


Ser Leu  Pro Val Thr Asp Thr  Ser Ser Ala Tyr Thr  Gly Asp Thr 
    2705                 2710                 2715             


Thr Ser  Leu Pro Val Thr Asp  Thr Ser Ser Ser Ser  Thr Gly Asp 
    2720                 2725                 2730             


Thr Thr  Pro Leu Leu Val Thr  Glu Thr Ser Ser Val  Ser Thr Gly 
    2735                 2740                 2745             


Asp Thr  Thr Pro Leu Pro Val  Thr Asp Thr Ser Ser  Ala Ser Thr 
    2750                 2755                 2760             


Gly His  Ala Thr Pro Leu Pro  Val Thr Asn Thr Ser  Ser Val Ser 
    2765                 2770                 2775             


Thr Gly  His Ala Thr Pro Leu  His Val Thr Ser Pro  Ser Ser Ala 
    2780                 2785                 2790             


Ser Thr  Gly His Thr Thr Pro  Leu Pro Val Thr Asp  Ala Ser Ser 
    2795                 2800                 2805             


Val Ser  Thr Gly His Ala Thr  Ser Leu Pro Val Thr  Asp Ala Ser 
    2810                 2815                 2820             


Ser Val  Phe Thr Gly His Ala  Thr Ser Leu Pro Val  Thr Ile Pro 
    2825                 2830                 2835             


Ser Ser  Ala Ser Ser Gly His  Thr Thr Pro Leu Pro  Val Thr Asp 
    2840                 2845                 2850             


Ala Ser  Ser Val Ser Thr Gly  His Ala Thr Ser Leu  Pro Val Thr 
    2855                 2860                 2865             


Asp Ala  Ser Ser Val Ser Thr  Gly His Ala Thr Pro  Leu Pro Val 
    2870                 2875                 2880             


Thr Asp  Ala Ser Ser Val Ser  Thr Gly His Ala Thr  Pro Leu Pro 
    2885                 2890                 2895             


Leu Thr  Ser Leu Ser Ser Val  Ser Thr Gly Asp Thr  Thr Pro Leu 
    2900                 2905                 2910             


Pro Val  Thr Asp Thr Ser Ser  Ala Ser Thr Gly Gln  Ala Thr Pro 
    2915                 2920                 2925             


Leu Pro  Val Thr Ser Leu Ser  Ser Val Ser Thr Gly  Asp Thr Thr 
    2930                 2935                 2940             


Pro Leu  Pro Val Thr Asp Thr  Ser Ser Ala Ser Thr  Gly His Ala 
    2945                 2950                 2955             


Thr Ser  Leu Pro Val Thr Asp  Thr Ser Ser Ala Ser  Thr Gly His 
    2960                 2965                 2970             


Ala Thr  Pro Leu Pro Asp Thr  Asp Thr Ser Ser Ala  Ser Thr Gly 
    2975                 2980                 2985             


His Ala  Thr Leu Leu Pro Val  Thr Asp Thr Ser Ser  Ala Ser Ile 
    2990                 2995                 3000             


Gly His  Ala Thr Ser Leu Pro  Val Thr Asp Thr Ser  Ser Ile Ser 
    3005                 3010                 3015             


Thr Gly  His Ala Thr Pro Leu  His Val Thr Ser Pro  Ser Ser Ala 
    3020                 3025                 3030             


Ser Thr  Gly His Ala Thr Pro  Leu Pro Val Thr Asp  Thr Ser Ser 
    3035                 3040                 3045             


Ala Ser  Thr Gly His Ala Asn  Pro Leu His Val Thr  Ser Pro Ser 
    3050                 3055                 3060             


Ser Ala  Ser Thr Gly His Ala  Thr Pro Leu Pro Val  Thr Asp Thr 
    3065                 3070                 3075             


Ser Ser  Ala Ser Thr Gly His  Ala Thr Pro Leu Pro  Val Thr Ser 
    3080                 3085                 3090             


Leu Ser  Ser Val Ser Thr Gly  Asp Thr Thr Pro Leu  Pro Val Thr 
    3095                 3100                 3105             


Ser Pro  Ser Ser Ala Ser Thr  Gly His Thr Thr Pro  Leu Pro Val 
    3110                 3115                 3120             


Thr Asp  Thr Ser Ser Ala Ser  Thr Gly Gln Ala Thr  Ala Leu Pro 
    3125                 3130                 3135             


Val Thr  Ser Thr Ser Ser Ala  Ser Thr Gly Asp Thr  Thr Pro Leu 
    3140                 3145                 3150             


Pro Val  Thr Asp Thr Ser Ser  Ala Ser Thr Gly Gln  Ala Thr Pro 
    3155                 3160                 3165             


Leu Pro  Val Thr Ser Leu Ser  Ser Val Ser Thr Gly  Asp Thr Thr 
    3170                 3175                 3180             


Pro Leu  Pro Val Thr Ser Pro  Ser Ser Ala Ser Thr  Gly His Ala 
    3185                 3190                 3195             


Thr Pro  Leu Leu Val Thr Asp  Ala Ser Ser Ala Ser  Thr Gly Gln 
    3200                 3205                 3210             


Ala Thr  Pro Leu Pro Val Thr  Ser Leu Ser Ser Val  Ser Thr Gly 
    3215                 3220                 3225             


Asp Thr  Thr Pro Leu Pro Val  Thr Ser Pro Ser Ser  Ala Ser Thr 
    3230                 3235                 3240             


Gly His  Ala Thr Ser Leu Pro  Val Thr Asp Thr Ser  Ser Ala Ser 
    3245                 3250                 3255             


Thr Gly  Asp Thr Thr Ser Leu  Pro Val Thr Asp Thr  Ser Ser Ala 
    3260                 3265                 3270             


Tyr Thr  Gly Asp Thr Thr Ser  Leu Pro Val Thr Asp  Thr Ser Ser 
    3275                 3280                 3285             


Ser Ser  Thr Gly Asp Thr Thr  Pro Leu Leu Val Thr  Glu Thr Ser 
    3290                 3295                 3300             


Ser Val  Ser Thr Gly His Ala  Thr Pro Leu Leu Val  Thr Asp Ala 
    3305                 3310                 3315             


Ser Ser  Ala Ser Thr Gly His  Ala Thr Pro Leu His  Val Thr Ser 
    3320                 3325                 3330             


Pro Ser  Ser Ala Ser Thr Gly  Asp Thr Thr Pro Val  Pro Val Thr 
    3335                 3340                 3345             


Asp Thr  Ser Ser Val Ser Thr  Gly His Ala Thr Pro  Leu Pro Val 
    3350                 3355                 3360             


Thr Gly  Leu Ser Ser Ala Ser  Thr Gly Asp Thr Thr  Arg Leu Pro 
    3365                 3370                 3375             


Val Thr  Asp Ile Ser Ser Ala  Ser Thr Gly Gln Ala  Thr Pro Leu 
    3380                 3385                 3390             


Pro Val  Thr Asn Thr Ser Ser  Val Ser Thr Gly Asp  Thr Met Pro 
    3395                 3400                 3405             


Leu Pro  Val Thr Ser Pro Ser  Ser Ala Ser Thr Gly  His Ala Thr 
    3410                 3415                 3420             


Pro Leu  Pro Val Thr Ser Thr  Ser Ser Ala Ser Thr  Gly His Ala 
    3425                 3430                 3435             


Thr Pro  Val Pro Val Thr Ser  Thr Ser Ser Ala Ser  Thr Gly His 
    3440                 3445                 3450             


Thr Thr  Pro Leu Pro Val Thr  Asp Thr Ser Ser Ala  Ser Thr Gly 
    3455                 3460                 3465             


Asp Thr  Thr Pro Leu Pro Val  Thr Ser Pro Ser Ser  Ala Ser Thr 
    3470                 3475                 3480             


Gly His  Thr Thr Pro Leu His  Val Thr Ile Pro Ser  Ser Ala Ser 
    3485                 3490                 3495             


Thr Gly  Asp Thr Ser Thr Leu  Pro Val Thr Gly Ala  Ser Ser Ala 
    3500                 3505                 3510             


Ser Thr  Gly His Ala Thr Pro  Leu Pro Val Thr Asp  Thr Ser Ser 
    3515                 3520                 3525             


Val Ser  Thr Gly His Ala Thr  Pro Leu Pro Val Thr  Ser Leu Ser 
    3530                 3535                 3540             


Ser Val  Ser Thr Gly Asp Thr  Thr Pro Leu Pro Val  Thr Asp Ala 
    3545                 3550                 3555             


Ser Ser  Ala Ser Thr Gly Gln  Ala Thr Pro Leu Pro  Val Thr Ser 
    3560                 3565                 3570             


Leu Ser  Ser Val Ser Thr Gly  Asp Thr Thr Pro Leu  Leu Val Thr 
    3575                 3580                 3585             


Asp Ala  Ser Ser Val Ser Thr  Gly His Ala Thr Pro  Leu Pro Val 
    3590                 3595                 3600             


Thr Asp  Thr Ser Ser Ala Ser  Thr Gly Asp Thr Thr  Arg Leu Pro 
    3605                 3610                 3615             


Val Thr  Asp Thr Ser Ser Ala  Ser Thr Gly Gln Ala  Thr Pro Leu 
    3620                 3625                 3630             


Pro Val  Thr Ser Leu Ser Ser  Val Ser Thr Gly Asp  Thr Thr Pro 
    3635                 3640                 3645             


Leu Leu  Val Thr Asp Ala Ser  Ser Val Ser Thr Gly  His Ala Thr 
    3650                 3655                 3660             


Pro Leu  Pro Val Thr Asp Thr  Ser Ser Ala Ser Thr  Gly Asp Thr 
    3665                 3670                 3675             


Thr Arg  Leu Pro Val Thr Asp  Thr Ser Ser Ala Ser  Thr Gly Gln 
    3680                 3685                 3690             


Ala Thr  Pro Leu Pro Val Thr  Ile Pro Ser Ser Ser  Ser Ser Gly 
    3695                 3700                 3705             


His Thr  Thr Pro Leu Pro Val  Thr Ser Thr Ser Ser  Val Ser Thr 
    3710                 3715                 3720             


Gly His  Val Thr Pro Leu His  Val Thr Ser Pro Ser  Ser Ala Ser 
    3725                 3730                 3735             


Thr Gly  His Val Thr Pro Leu  Pro Val Thr Ser Thr  Ser Ser Ala 
    3740                 3745                 3750             


Ser Thr  Gly His Ala Thr Pro  Leu Leu Val Thr Asp  Ala Ser Ser 
    3755                 3760                 3765             


Val Ser  Thr Gly His Ala Thr  Pro Leu Pro Val Thr  Asp Ala Ser 
    3770                 3775                 3780             


Ser Ala  Ser Thr Gly Asp Thr  Thr Pro Leu Pro Val  Thr Asp Thr 
    3785                 3790                 3795             


Ser Ser  Ala Ser Thr Gly Gln  Ala Thr Pro Leu Pro  Val Thr Ser 
    3800                 3805                 3810             


Leu Ser  Ser Val Ser Thr Gly  Asp Thr Thr Pro Leu  Pro Val Thr 
    3815                 3820                 3825             


Asp Ala  Ser Ser Ala Ser Thr  Gly His Ala Thr Pro  Leu Pro Val 
    3830                 3835                 3840             


Thr Ile  Pro Ser Ser Val Ser  Thr Gly Asp Thr Met  Pro Leu Pro 
    3845                 3850                 3855             


Val Thr  Ser Pro Ser Ser Ala  Ser Thr Gly His Ala  Thr Pro Leu 
    3860                 3865                 3870             


Pro Val  Thr Gly Leu Ser Ser  Ala Ser Thr Gly Asp  Thr Thr Pro 
    3875                 3880                 3885             


Leu Pro  Val Thr Asp Thr Ser  Ser Ala Ser Thr Arg  His Ala Thr 
    3890                 3895                 3900             


Pro Leu  Pro Val Thr Asp Thr  Ser Ser Ala Ser Thr  Asp Asp Thr 
    3905                 3910                 3915             


Thr Arg  Leu Pro Val Thr Asp  Val Ser Ser Ala Ser  Thr Gly His 
    3920                 3925                 3930             


Ala Thr  Pro Leu Pro Val Thr  Ser Thr Ser Ser Ala  Ser Thr Gly 
    3935                 3940                 3945             


Asp Thr  Thr Pro Leu Pro Val  Thr Asp Thr Ser Ser  Val Ser Thr 
    3950                 3955                 3960             


Gly His  Ala Thr Ser Leu Pro  Val Thr Ser Arg Ser  Ser Ala Ser 
    3965                 3970                 3975             


Thr Gly  His Ala Thr Pro Leu  Pro Val Thr Asp Thr  Ser Ser Val 
    3980                 3985                 3990             


Ser Thr  Gly His Ala Thr Pro  Leu Pro Val Thr Ser  Thr Ser Ser 
    3995                 4000                 4005             


Val Ser  Thr Gly His Ala Thr  Pro Leu Pro Val Thr  Ser Pro Ser 
    4010                 4015                 4020             


Ser Ala  Ser Thr Gly His Ala  Thr Pro Val Pro Val  Thr Ser Thr 
    4025                 4030                 4035             


Ser Ser  Ala Ser Thr Gly Asp  Thr Thr Pro Leu Pro  Val Thr Asn 
    4040                 4045                 4050             


Ala Ser  Ser Leu Ser Thr Gly  His Ala Thr Pro Leu  His Val Thr 
    4055                 4060                 4065             


Ser Pro  Ser Ser Ala Ser Arg  Gly Asp Thr Ser Thr  Leu Pro Val 
    4070                 4075                 4080             


Thr Asp  Ala Ser Ser Ala Ser  Thr Gly His Ala Thr  Pro Leu Pro 
    4085                 4090                 4095             


Leu Thr  Ser Leu Ser Ser Val  Ser Thr Gly Asp Thr  Thr Pro Leu 
    4100                 4105                 4110             


Pro Val  Thr Asp Thr Ser Ser  Ala Ser Thr Gly Gln  Ala Thr Pro 
    4115                 4120                 4125             


Leu Pro  Val Thr Ser Leu Ser  Ser Val Ser Thr Gly  Asp Thr Thr 
    4130                 4135                 4140             


Pro Leu  Pro Val Thr Ile Pro  Ser Ser Ala Ser Ser  Gly His Thr 
    4145                 4150                 4155             


Thr Ser  Leu Pro Val Thr Asp  Ala Ser Ser Val Ser  Thr Gly His 
    4160                 4165                 4170             


Gly Thr  Pro Leu Pro Val Thr  Ser Thr Ser Ser Ala  Ser Thr Gly 
    4175                 4180                 4185             


Asp Thr  Thr Pro Leu Pro Val  Thr Asp Thr Ser Ser  Ala Ser Thr 
    4190                 4195                 4200             


Gly His  Ala Thr Pro Leu Pro  Val Thr Asp Thr Ser  Ser Ala Ser 
    4205                 4210                 4215             


Thr Gly  His Ala Thr Pro Leu  Pro Val Thr Ser Leu  Ser Ser Val 
    4220                 4225                 4230             


Ser Thr  Gly His Ala Thr Pro  Leu Ala Val Ser Ser  Ala Thr Ser 
    4235                 4240                 4245             


Ala Ser  Thr Val Ser Ser Asp  Ser Pro Leu Lys Met  Glu Thr Pro 
    4250                 4255                 4260             


Gly Met  Thr Thr Pro Ser Leu  Lys Thr Asp Gly Gly  Arg Arg Thr 
    4265                 4270                 4275             


Ala Thr  Ser Pro Pro Pro Thr  Thr Ser Gln Thr Ile  Ile Ser Thr 
    4280                 4285                 4290             


Ile Pro  Ser Thr Ala Met His  Thr Arg Ser Thr Ala  Ala Pro Ile 
    4295                 4300                 4305             


Pro Ile  Leu Pro Glu Arg Gly  Val Ser Leu Phe Pro  Tyr Gly Ala 
    4310                 4315                 4320             


Gly Ala  Gly Asp Leu Glu Phe  Val Arg Arg Thr Val  Asp Phe Thr 
    4325                 4330                 4335             


Ser Pro  Leu Phe Lys Pro Ala  Thr Gly Phe Pro Leu  Gly Ser Ser 
    4340                 4345                 4350             


Leu Arg  Asp Ser Leu Tyr Phe  Thr Asp Asn Gly Gln  Ile Ile Phe 
    4355                 4360                 4365             


Pro Glu  Ser Asp Tyr Gln Ile  Phe Ser Tyr Pro Asn  Pro Leu Pro 
    4370                 4375                 4380             


Thr Gly  Phe Thr Gly Arg Asp  Pro Val Ala Leu Val  Ala Pro Phe 
    4385                 4390                 4395             


Trp Asp  Asp Ala Asp Phe Ser  Thr Gly Arg Gly Thr  Thr Phe Tyr 
    4400                 4405                 4410             


Gln Glu  Tyr Glu Thr Phe Tyr  Gly Glu His Ser Leu  Leu Val Gln 
    4415                 4420                 4425             


Gln Ala  Glu Ser Trp Ile Arg  Lys Met Thr Asn Asn  Gly Gly Tyr 
    4430                 4435                 4440             


Lys Ala  Arg Trp Ala Leu Lys  Val Thr Trp Val Asn  Ala His Ala 
    4445                 4450                 4455             


Tyr Pro  Ala Gln Trp Thr Leu  Gly Ser Asn Thr Tyr  Gln Ala Ile 
    4460                 4465                 4470             


Leu Ser  Thr Asp Gly Ser Arg  Ser Tyr Ala Leu Phe  Leu Tyr Gln 
    4475                 4480                 4485             


Ser Gly  Gly Met Gln Trp Asp  Val Ala Gln Arg Ser  Gly Asn Pro 
    4490                 4495                 4500             


Val Leu  Met Gly Phe Ser Ser  Gly Asp Gly Tyr Phe  Glu Asn Ser 
    4505                 4510                 4515             


Pro Leu  Met Ser Gln Pro Val  Trp Glu Arg Tyr Arg  Pro Asp Arg 
    4520                 4525                 4530             


Phe Leu  Asn Ser Asn Ser Gly  Leu Gln Gly Leu Gln  Phe Tyr Arg 
    4535                 4540                 4545             


Leu His  Arg Glu Glu Arg Pro  Asn Tyr Arg Leu Glu  Cys Leu Gln 
    4550                 4555                 4560             


Trp Leu  Lys Ser Gln Pro Arg  Trp Pro Ser Trp Gly  Trp Asn Gln 
    4565                 4570                 4575             


Val Ser  Cys Pro Cys Ser Trp  Gln Gln Gly Arg Arg  Asp Leu Arg 
    4580                 4585                 4590             


Phe Gln  Pro Val Ser Ile Gly  Arg Trp Gly Leu Gly  Ser Arg Gln 
    4595                 4600                 4605             


Leu Cys  Ser Phe Thr Ser Trp  Arg Gly Gly Val Cys  Cys Ser Tyr 
    4610                 4615                 4620             


Gly Pro  Trp Gly Glu Phe Arg  Glu Gly Trp His Val  Gln Arg Pro 
    4625                 4630                 4635             


Trp Gln  Leu Ala Gln Glu Leu  Glu Pro Gln Ser Trp  Cys Cys Arg 
    4640                 4645                 4650             


Trp Asn  Asp Lys Pro Tyr Leu  Cys Ala Leu Tyr Gln  Gln Arg Arg 
    4655                 4660                 4665             


Pro His  Val Gly Cys Ala Thr  Tyr Arg Pro Pro Gln  Pro Ala Trp 
    4670                 4675                 4680             


Met Phe  Gly Asp Pro His Ile  Thr Thr Leu Asp Gly  Val Ser Tyr 
    4685                 4690                 4695             


Thr Phe  Asn Gly Leu Gly Asp  Phe Leu Leu Val Gly  Ala Gln Asp 
    4700                 4705                 4710             


Gly Asn  Ser Ser Phe Leu Leu  Gln Gly Arg Thr Ala  Gln Thr Gly 
    4715                 4720                 4725             


Ser Ala  Gln Ala Thr Asn Phe  Ile Ala Phe Ala Ala  Gln Tyr Arg 
    4730                 4735                 4740             


Ser Ser  Ser Leu Gly Pro Val  Thr Val Gln Trp Leu  Leu Glu Pro 
    4745                 4750                 4755             


His Asp  Ala Ile Arg Val Leu  Leu Asp Asn Gln Thr  Val Thr Phe 
    4760                 4765                 4770             


Gln Pro  Asp His Glu Asp Gly  Gly Gly Gln Glu Thr  Phe Asn Ala 
    4775                 4780                 4785             


Thr Gly  Val Leu Leu Ser Arg  Asn Gly Ser Glu Val  Ser Ala Ser 
    4790                 4795                 4800             


Phe Asp  Gly Trp Ala Thr Val  Ser Val Ile Ala Leu  Ser Asn Ile 
    4805                 4810                 4815             


Leu His  Ala Ser Ala Ser Leu  Pro Pro Glu Tyr Gln  Asn Arg Thr 
    4820                 4825                 4830             


Glu Gly  Leu Leu Gly Val Trp  Asn Asn Asn Pro Glu  Asp Asp Phe 
    4835                 4840                 4845             


Arg Met  Pro Asn Gly Ser Thr  Ile Pro Pro Gly Ser  Pro Glu Glu 
    4850                 4855                 4860             


Met Leu  Phe His Phe Gly Met  Thr Trp Gln Ile Asn  Gly Thr Gly 
    4865                 4870                 4875             


Leu Leu  Gly Lys Arg Asn Asp  Gln Leu Pro Ser Asn  Phe Thr Pro 
    4880                 4885                 4890             


Val Phe  Tyr Ser Gln Leu Gln  Lys Asn Ser Ser Trp  Ala Glu His 
    4895                 4900                 4905             


Leu Ile  Ser Asn Cys Asp Gly  Asp Ser Ser Cys Ile  Tyr Asp Thr 
    4910                 4915                 4920             


Leu Ala  Leu Arg Asn Ala Ser  Ile Gly Leu His Thr  Arg Glu Val 
    4925                 4930                 4935             


Ser Lys  Asn Tyr Glu Gln Ala  Asn Ala Thr Leu Asn  Gln Tyr Pro 
    4940                 4945                 4950             


Pro Ser  Ile Asn Gly Gly Arg  Val Ile Glu Ala Tyr  Lys Gly Gln 
    4955                 4960                 4965             


Thr Thr  Leu Ile Gln Tyr Thr  Ser Asn Ala Glu Asp  Ala Asn Phe 
    4970                 4975                 4980             


Thr Leu  Arg Asp Ser Cys Thr  Asp Leu Glu Leu Phe  Glu Asn Gly 
    4985                 4990                 4995             


Thr Leu  Leu Trp Thr Pro Lys  Ser Leu Glu Pro Phe  Thr Leu Glu 
    5000                 5005                 5010             


Ile Leu  Ala Arg Ser Ala Lys  Ile Gly Leu Ala Ser  Ala Leu Gln 
    5015                 5020                 5025             


Pro Arg  Thr Val Val Cys His  Cys Asn Ala Glu Ser  Gln Cys Leu 
    5030                 5035                 5040             


Tyr Asn  Gln Thr Ser Arg Val  Gly Asn Ser Ser Leu  Glu Val Ala 
    5045                 5050                 5055             


Gly Cys  Lys Cys Asp Gly Gly  Thr Phe Gly Arg Tyr  Cys Glu Gly 
    5060                 5065                 5070             


Ser Glu  Asp Ala Cys Glu Glu  Pro Cys Phe Pro Ser  Val His Cys 
    5075                 5080                 5085             


Val Pro  Gly Lys Gly Cys Glu  Ala Cys Pro Pro Asn  Leu Thr Gly 
    5090                 5095                 5100             


Asp Gly  Arg His Cys Ala Ala  Leu Gly Ser Ser Phe  Leu Cys Gln 
    5105                 5110                 5115             


Asn Gln  Ser Cys Pro Val Asn  Tyr Cys Tyr Asn Gln  Gly His Cys 
    5120                 5125                 5130             


Tyr Ile  Ser Gln Thr Leu Gly  Cys Gln Pro Met Cys  Thr Cys Pro 
    5135                 5140                 5145             


Pro Ala  Phe Thr Asp Ser Arg  Cys Phe Leu Ala Gly  Asn Asn Phe 
    5150                 5155                 5160             


Ser Pro  Thr Val Asn Leu Glu  Leu Pro Leu Arg Val  Ile Gln Leu 
    5165                 5170                 5175             


Leu Leu  Ser Glu Glu Glu Asn  Ala Ser Met Ala Glu  Val Asn Ala 
    5180                 5185                 5190             


Ser Val  Ala Tyr Arg Leu Gly  Thr Leu Asp Met Arg  Ala Phe Leu 
    5195                 5200                 5205             


Arg Asn  Ser Gln Val Glu Arg  Ile Asp Ser Ala Ala  Pro Ala Ser 
    5210                 5215                 5220             


Gly Ser  Pro Ile Gln His Trp  Met Val Ile Ser Glu  Phe Gln Tyr 
    5225                 5230                 5235             


Arg Pro  Arg Gly Pro Val Ile  Asp Phe Leu Asn Asn  Gln Leu Leu 
    5240                 5245                 5250             


Ala Ala  Val Val Glu Ala Phe  Leu Tyr His Val Pro  Arg Arg Ser 
    5255                 5260                 5265             


Glu Glu  Pro Arg Asn Asp Val  Val Phe Gln Pro Ile  Ser Gly Glu 
    5270                 5275                 5280             


Asp Val  Arg Asp Val Thr Ala  Leu Asn Val Ser Thr  Leu Lys Ala 
    5285                 5290                 5295             


Tyr Phe  Arg Cys Asp Gly Tyr  Lys Gly Tyr Asp Leu  Val Tyr Ser 
    5300                 5305                 5310             


Pro Gln  Ser Gly Phe Thr Cys  Val Ser Pro Cys Ser  Arg Gly Tyr 
    5315                 5320                 5325             


Cys Asp  His Gly Gly Gln Cys  Gln His Leu Pro Ser  Gly Pro Arg 
    5330                 5335                 5340             


Cys Ser  Cys Val Ser Phe Ser  Ile Tyr Thr Ala Trp  Gly Glu His 
    5345                 5350                 5355             


Cys Glu  His Leu Ser Met Lys  Leu Asp Ala Phe Phe  Gly Ile Phe 
    5360                 5365                 5370             


Phe Gly  Ala Leu Gly Gly Leu  Leu Leu Leu Gly Val  Gly Thr Phe 
    5375                 5380                 5385             


Val Val  Leu Arg Phe Trp Gly  Cys Ser Gly Ala Arg  Phe Ser Tyr 
    5390                 5395                 5400             


Phe Leu  Asn Ser Ala Glu Ala  Leu Pro 
    5405                 5410         


<210>  4441
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  4441

Met Thr Ser Arg Thr Arg Val Thr Trp Pro Ser Pro Pro Arg Pro Leu 
1               5                   10                  15      


Pro Val Pro Ala Ala Ala Ala Val Ala Phe Gly Ala Lys Gly Thr Asp 
            20                  25                  30          


Pro Ala Glu Ala Arg Ser Ser Arg Gly Ile Glu Glu Ala Gly Pro Arg 
        35                  40                  45              


Ala His Gly Arg Ala Gly Arg Glu Pro Glu Arg Arg Arg Ser Arg Gln 
    50                  55                  60                  


Gln Arg Arg Gly Gly Leu Gln Ala Arg Arg Ser Thr Leu Leu Lys Thr 
65                  70                  75                  80  


Cys Ala Arg Ala Arg Ala Thr Ala Pro Gly Ala Met Lys Met Val Ala 
                85                  90                  95      


Pro Trp Thr Arg Phe Tyr Ser Asn Ser Cys Cys Leu Cys Cys His Val 
            100                 105                 110         


Arg Thr Gly Thr Ile Leu Leu Gly Val Trp Tyr Leu Ile Ile Asn Ala 
        115                 120                 125             


Val Val Leu Leu Ile Leu Leu Ser Ala Leu Ala Asp Pro Asp Gln Tyr 
    130                 135                 140                 


Asn Phe Ser Ser Ser Glu Leu Gly Gly Asp Phe Glu Phe Met Asp Asp 
145                 150                 155                 160 


Ala Asn Met Cys Ile Ala Ile Ala Ile Ser Leu Leu Met Ile Leu Ile 
                165                 170                 175     


Cys Ala Met Ala Thr Tyr Gly Ala Tyr Lys Gln Arg Ala Ala Trp Ile 
            180                 185                 190         


Ile Pro Phe Phe Cys Tyr Gln Ile Phe Asp Phe Ala Leu Asn Met Leu 
        195                 200                 205             


Val Ala Ile Thr Val Leu Ile Tyr Pro Asn Ser Ile Gln Glu Tyr Ile 
    210                 215                 220                 


Arg Gln Leu Pro Pro Asn Phe Pro Tyr Arg Asp Asp Val Met Ser Val 
225                 230                 235                 240 


Asn Pro Thr Cys Leu Val Leu Ile Ile Leu Leu Phe Ile Ser Ile Ile 
                245                 250                 255     


Leu Thr Phe Lys Gly Tyr Leu Ile Ser Cys Val Trp Asn Cys Tyr Arg 
            260                 265                 270         


Tyr Ile Asn Gly Arg Asn Ser Ser Asp Val Leu Val Tyr Val Thr Ser 
        275                 280                 285             


Asn Asp Thr Thr Val Leu Leu Pro Pro Tyr Asp Asp Ala Thr Val Asn 
    290                 295                 300                 


Gly Ala Ala Lys Glu Pro Pro Pro Pro Tyr Val Ser Ala 
305                 310                 315         


<210>  4442
<211>  554
<212>  PRT
<213>  Homo sapiens

<400>  4442

Met Ala Glu Ala Ala Thr Gly Phe Leu Glu Gln Leu Lys Ser Cys Ile 
1               5                   10                  15      


Val Trp Ser Trp Thr Tyr Leu Trp Thr Val Trp Phe Phe Ile Val Leu 
            20                  25                  30          


Phe Leu Val Tyr Ile Leu Arg Val Pro Leu Lys Ile Asn Asp Asn Leu 
        35                  40                  45              


Ser Thr Val Ser Met Phe Leu Asn Thr Leu Thr Pro Lys Phe Tyr Val 
    50                  55                  60                  


Ala Leu Thr Gly Thr Ser Ser Leu Ile Ser Gly Leu Ile Leu Ile Phe 
65                  70                  75                  80  


Glu Trp Trp Tyr Phe Arg Lys Tyr Gly Thr Ser Phe Ile Glu Gln Val 
                85                  90                  95      


Ser Val Ser His Leu Arg Pro Leu Leu Gly Gly Val Asp Asn Asn Ser 
            100                 105                 110         


Ser Asn Asn Ser Asn Ser Ser Asn Gly Asp Ser Asp Ser Asn Arg Gln 
        115                 120                 125             


Ser Val Ser Glu Cys Lys Val Trp Arg Asn Pro Leu Asn Leu Phe Arg 
    130                 135                 140                 


Gly Ala Glu Tyr Asn Arg Tyr Thr Trp Val Thr Gly Arg Glu Pro Leu 
145                 150                 155                 160 


Thr Tyr Tyr Asp Met Asn Leu Ser Ala Gln Asp His Gln Thr Phe Phe 
                165                 170                 175     


Thr Cys Asp Ser Asp His Leu Arg Pro Ala Asp Ala Ile Met Gln Lys 
            180                 185                 190         


Ala Trp Arg Glu Arg Asn Pro Gln Ala Arg Ile Ser Ala Ala His Glu 
        195                 200                 205             


Ala Leu Glu Ile Asn Glu Cys Ala Thr Ala Tyr Ile Leu Leu Ala Glu 
    210                 215                 220                 


Glu Glu Ala Thr Thr Ile Ala Glu Ala Glu Lys Leu Phe Lys Gln Ala 
225                 230                 235                 240 


Leu Lys Ala Gly Asp Gly Cys Tyr Arg Arg Ser Gln Gln Leu Gln His 
                245                 250                 255     


His Gly Ser Gln Tyr Glu Ala Gln His Arg Arg Asp Thr Asn Val Leu 
            260                 265                 270         


Val Tyr Ile Lys Arg Arg Leu Ala Met Cys Ala Arg Arg Leu Gly Arg 
        275                 280                 285             


Thr Arg Glu Ala Val Lys Met Met Arg Asp Leu Met Lys Glu Phe Pro 
    290                 295                 300                 


Leu Leu Ser Met Phe Asn Ile His Glu Asn Leu Leu Glu Ala Leu Leu 
305                 310                 315                 320 


Glu Leu Gln Ala Tyr Ala Asp Val Gln Ala Val Leu Ala Lys Tyr Asp 
                325                 330                 335     


Asp Ile Ser Leu Pro Lys Ser Ala Thr Ile Cys Tyr Thr Ala Ala Leu 
            340                 345                 350         


Leu Lys Ala Arg Ala Val Ser Asp Lys Phe Ser Pro Glu Ala Ala Ser 
        355                 360                 365             


Arg Arg Gly Leu Ser Thr Ala Glu Met Asn Ala Val Glu Ala Ile His 
    370                 375                 380                 


Arg Ala Val Glu Phe Asn Pro His Val Pro Lys Tyr Leu Leu Glu Met 
385                 390                 395                 400 


Lys Ser Leu Ile Leu Pro Pro Glu His Ile Leu Lys Arg Gly Asp Ser 
                405                 410                 415     


Glu Ala Ile Ala Tyr Ala Phe Phe His Leu Ala His Trp Lys Arg Val 
            420                 425                 430         


Glu Gly Ala Leu Asn Leu Leu His Cys Thr Trp Glu Gly Thr Phe Arg 
        435                 440                 445             


Met Ile Pro Tyr Pro Leu Glu Lys Gly His Leu Phe Tyr Pro Tyr Pro 
    450                 455                 460                 


Ile Cys Thr Glu Thr Ala Asp Arg Glu Leu Leu Pro Ser Phe His Glu 
465                 470                 475                 480 


Val Ser Val Tyr Pro Lys Lys Glu Leu Pro Phe Phe Ile Leu Phe Thr 
                485                 490                 495     


Ala Gly Leu Cys Ser Phe Thr Ala Met Leu Ala Leu Leu Thr His Gln 
            500                 505                 510         


Phe Pro Glu Leu Met Gly Val Phe Ala Lys Ala Phe Leu Ser Thr Leu 
        515                 520                 525             


Phe Ala Pro Leu Asn Phe Val Met Glu Lys Val Glu Ser Ile Leu Pro 
    530                 535                 540                 


Ser Ser Leu Trp His Gln Leu Thr Arg Ile 
545                 550                 


<210>  4443
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  4443

Met Lys Pro Ala Leu Leu Glu Val Met Arg Met Asn Arg Ile Cys Arg 
1               5                   10                  15      


Met Val Leu Ala Thr Cys Leu Gly Ser Phe Ile Leu Val Ile Phe Tyr 
            20                  25                  30          


Phe Gln Ser Met Leu His Pro Val Met Arg Arg Asn Pro Phe Gly Val 
        35                  40                  45              


Asp Ile Cys Cys Arg Lys Gly Ser Arg Ser Pro Leu Gln Glu Leu Tyr 
    50                  55                  60                  


Asn Pro Ile Gln Leu Glu Leu Ser Asn Thr Ala Val Leu His Gln Met 
65                  70                  75                  80  


Arg Arg Asp Gln Val Thr Asp Thr Cys Arg Ala Asn Ser Ala Thr Ser 
                85                  90                  95      


Arg Lys Arg Arg Val Leu Thr Pro Asn Asp Leu Lys His Leu Val Val 
            100                 105                 110         


Asp Glu Asp His Glu Leu Ile Tyr Cys Tyr Val Pro Lys Val Ala Cys 
        115                 120                 125             


Thr Asn Trp Lys Arg Leu Met Met Val Leu Thr Gly Arg Gly Lys Tyr 
    130                 135                 140                 


Ser Asp Pro Met Glu Ile Pro Ala Asn Glu Ala His Val Ser Ala Asn 
145                 150                 155                 160 


Leu Lys Thr Leu Asn Gln Tyr Ser Ile Pro Glu Ile Asn His Arg Leu 
                165                 170                 175     


Lys Ser Tyr Met Lys Phe Leu Phe Val Arg Glu Pro Phe Glu Arg Leu 
            180                 185                 190         


Val Ser Ala Tyr Arg Asn Lys Phe Thr Gln Lys Tyr Asn Ile Ser Phe 
        195                 200                 205             


His Lys Arg Tyr Gly Thr Lys Ile Ile Lys Arg Gln Arg Lys Asn Ala 
    210                 215                 220                 


Thr Gln Glu Ala Leu Arg Lys Gly Asp Asp Val Lys Phe Glu Glu Phe 
225                 230                 235                 240 


Val Ala Tyr Leu Ile Asp Pro His Thr Gln Arg Glu Glu Pro Phe Asn 
                245                 250                 255     


Glu His Trp Gln Thr Val Tyr Ser Leu Cys His Pro Cys His Ile His 
            260                 265                 270         


Tyr Asp Leu Val Gly Lys Tyr Glu Thr Leu Glu Glu Asp Ser Asn Tyr 
        275                 280                 285             


Val Leu Gln Leu Ala Gly Val Gly Ser Tyr Leu Lys Phe Pro Thr Tyr 
    290                 295                 300                 


Ala Lys Ser Thr Arg Thr Thr Asp Glu Met Thr Thr Glu Phe Phe Gln 
305                 310                 315                 320 


Asn Ile Ser Ser Glu His Gln Thr Gln Leu Tyr Glu Val Tyr Lys Leu 
                325                 330                 335     


Asp Phe Leu Met Phe Asn Tyr Ser Val Pro Ser Tyr Leu Lys Leu Glu 
            340                 345                 350         


<210>  4444
<211>  600
<212>  PRT
<213>  Homo sapiens

<400>  4444

Met Arg Ser Cys Leu Trp Arg Cys Arg His Leu Ser Gln Gly Val Gln 
1               5                   10                  15      


Trp Ser Leu Leu Leu Ala Val Leu Val Phe Phe Leu Phe Ala Leu Pro 
            20                  25                  30          


Ser Phe Ile Lys Glu Pro Gln Thr Lys Pro Ser Arg His Gln Arg Thr 
        35                  40                  45              


Glu Asn Ile Lys Glu Arg Ser Leu Gln Ser Leu Ala Lys Pro Lys Ser 
    50                  55                  60                  


Gln Ala Pro Thr Arg Ala Arg Arg Thr Thr Ile Tyr Ala Glu Pro Val 
65                  70                  75                  80  


Pro Glu Asn Asn Ala Leu Asn Thr Gln Thr Gln Pro Lys Ala His Thr 
                85                  90                  95      


Thr Gly Asp Arg Gly Lys Glu Ala Asn Gln Ala Pro Pro Glu Glu Gln 
            100                 105                 110         


Asp Lys Val Pro His Thr Ala Gln Arg Ala Ala Trp Lys Ser Pro Glu 
        115                 120                 125             


Lys Glu Lys Thr Met Val Asn Thr Leu Ser Pro Arg Gly Gln Asp Ala 
    130                 135                 140                 


Gly Met Ala Ser Gly Arg Thr Glu Ala Gln Ser Trp Lys Ser Gln Asp 
145                 150                 155                 160 


Thr Lys Thr Thr Gln Gly Asn Gly Gly Gln Thr Arg Lys Leu Thr Ala 
                165                 170                 175     


Ser Arg Thr Val Ser Glu Lys His Gln Gly Lys Ala Ala Thr Thr Ala 
            180                 185                 190         


Lys Thr Leu Ile Pro Lys Ser Gln His Arg Met Leu Ala Pro Thr Gly 
        195                 200                 205             


Ala Val Ser Thr Arg Thr Arg Gln Lys Gly Val Thr Thr Ala Val Ile 
    210                 215                 220                 


Pro Pro Lys Glu Lys Lys Pro Gln Ala Thr Pro Pro Pro Ala Pro Phe 
225                 230                 235                 240 


Gln Ser Pro Thr Thr Gln Arg Asn Gln Arg Leu Lys Ala Ala Asn Phe 
                245                 250                 255     


Lys Ser Glu Pro Arg Trp Asp Phe Glu Glu Lys Tyr Ser Phe Glu Ile 
            260                 265                 270         


Gly Gly Leu Gln Thr Thr Cys Pro Asp Ser Val Lys Ile Lys Ala Ser 
        275                 280                 285             


Lys Ser Leu Trp Leu Gln Lys Leu Phe Leu Pro Asn Leu Thr Leu Phe 
    290                 295                 300                 


Leu Asp Ser Arg His Phe Asn Gln Ser Glu Trp Asp Arg Leu Glu His 
305                 310                 315                 320 


Phe Ala Pro Pro Phe Gly Phe Met Glu Leu Asn Tyr Ser Leu Val Gln 
                325                 330                 335     


Lys Val Val Thr Arg Phe Pro Pro Val Pro Gln Gln Gln Leu Leu Leu 
            340                 345                 350         


Ala Ser Leu Pro Ala Gly Ser Leu Arg Cys Ile Thr Cys Ala Val Val 
        355                 360                 365             


Gly Asn Gly Gly Ile Leu Asn Asn Ser His Met Gly Gln Glu Ile Asp 
    370                 375                 380                 


Ser His Asp Tyr Val Phe Arg Leu Ser Gly Ala Leu Ile Lys Gly Tyr 
385                 390                 395                 400 


Glu Gln Asp Val Gly Thr Arg Thr Ser Phe Tyr Gly Phe Thr Ala Phe 
                405                 410                 415     


Ser Leu Thr Gln Ser Leu Leu Ile Leu Gly Asn Arg Gly Phe Lys Asn 
            420                 425                 430         


Val Pro Leu Gly Lys Asp Val Arg Tyr Leu His Phe Leu Glu Gly Thr 
        435                 440                 445             


Arg Asp Tyr Glu Trp Leu Glu Ala Leu Leu Met Asn Gln Thr Val Met 
    450                 455                 460                 


Ser Lys Asn Leu Phe Trp Phe Arg His Arg Pro Gln Glu Ala Phe Arg 
465                 470                 475                 480 


Glu Ala Leu His Met Asp Arg Tyr Leu Leu Leu His Pro Asp Phe Leu 
                485                 490                 495     


Arg Tyr Met Lys Asn Arg Phe Leu Arg Ser Lys Thr Leu Asp Gly Ala 
            500                 505                 510         


His Trp Arg Ile Tyr Arg Pro Thr Thr Gly Ala Leu Leu Leu Leu Thr 
        515                 520                 525             


Ala Leu Gln Leu Cys Asp Gln Val Ser Ala Tyr Gly Phe Ile Thr Glu 
    530                 535                 540                 


Gly His Glu Arg Phe Ser Asp His Tyr Tyr Asp Thr Ser Trp Lys Arg 
545                 550                 555                 560 


Leu Ile Phe Tyr Ile Asn His Asp Phe Lys Leu Glu Arg Glu Val Trp 
                565                 570                 575     


Lys Arg Leu His Asp Glu Gly Ile Ile Arg Leu Tyr Gln Arg Pro Gly 
            580                 585                 590         


Pro Gly Thr Ala Lys Ala Lys Asn 
        595                 600 


<210>  4445
<211>  1610
<212>  PRT
<213>  Homo sapiens

<400>  4445

Met Asn Thr Pro Lys Glu Glu Phe Gln Asp Trp Pro Ile Val Arg Ile 
1               5                   10                  15      


Ala Ala His Leu Pro Asp Leu Ile Val Tyr Gly His Phe Ser Pro Glu 
            20                  25                  30          


Arg Pro Phe Met Asp Tyr Phe Asp Gly Val Leu Met Phe Val Asp Ile 
        35                  40                  45              


Ser Gly Phe Thr Ala Met Thr Glu Lys Phe Ser Ser Ala Met Tyr Met 
    50                  55                  60                  


Asp Arg Gly Ala Glu Gln Leu Val Glu Ile Leu Asn Tyr His Ile Ser 
65                  70                  75                  80  


Ala Ile Val Glu Lys Val Leu Ile Phe Gly Gly Asp Ile Leu Lys Phe 
                85                  90                  95      


Ala Gly Asp Ala Leu Leu Ala Leu Trp Arg Val Glu Arg Lys Gln Leu 
            100                 105                 110         


Lys Asn Ile Ile Thr Val Val Ile Lys Cys Ser Leu Glu Ile His Gly 
        115                 120                 125             


Leu Phe Glu Thr Gln Glu Trp Glu Glu Gly Leu Asp Ile Arg Val Lys 
    130                 135                 140                 


Ile Gly Leu Ala Ala Gly His Ile Ser Met Leu Val Phe Gly Asp Glu 
145                 150                 155                 160 


Thr His Ser His Phe Leu Val Ile Gly Gln Ala Val Asp Asp Val Arg 
                165                 170                 175     


Leu Ala Gln Asn Met Ala Gln Met Asn Asp Val Ile Leu Ser Pro Asn 
            180                 185                 190         


Cys Trp Gln Leu Cys Asp Arg Ser Met Ile Glu Ile Glu Ser Val Pro 
        195                 200                 205             


Asp Gln Arg Ala Val Lys Val Asn Phe Leu Lys Pro Pro Pro Asn Phe 
    210                 215                 220                 


Asn Phe Asp Glu Phe Phe Thr Lys Cys Thr Thr Phe Met His Tyr Tyr 
225                 230                 235                 240 


Pro Ser Gly Glu His Lys Asn Leu Leu Arg Leu Ala Cys Thr Leu Lys 
                245                 250                 255     


Pro Asp Pro Glu Leu Glu Met Ser Leu Gln Lys Tyr Val Met Glu Ser 
            260                 265                 270         


Ile Leu Lys Gln Ile Asp Asn Lys Gln Leu Gln Gly Tyr Leu Ser Glu 
        275                 280                 285             


Leu Arg Pro Val Thr Ile Val Phe Val Asn Leu Met Phe Glu Asp Gln 
    290                 295                 300                 


Asp Lys Ala Glu Glu Ile Gly Pro Ala Ile Gln Asp Ala Tyr Met His 
305                 310                 315                 320 


Ile Thr Ser Val Leu Lys Ile Phe Gln Gly Gln Ile Asn Lys Val Phe 
                325                 330                 335     


Met Phe Asp Lys Gly Cys Ser Phe Leu Cys Val Phe Gly Phe Pro Gly 
            340                 345                 350         


Glu Lys Val Pro Asp Glu Leu Thr His Ala Leu Glu Cys Ala Met Asp 
        355                 360                 365             


Ile Phe Asp Phe Cys Ser Gln Val His Lys Ile Gln Thr Val Ser Ile 
    370                 375                 380                 


Gly Val Ala Ser Gly Ile Val Phe Cys Gly Ile Val Gly His Thr Val 
385                 390                 395                 400 


Arg His Glu Tyr Thr Val Ile Gly Gln Lys Val Asn Leu Ala Ala Arg 
                405                 410                 415     


Met Met Met Tyr Tyr Pro Gly Ile Val Thr Cys Asp Ser Val Thr Tyr 
            420                 425                 430         


Asn Gly Ser Asn Leu Pro Ala Tyr Phe Phe Lys Glu Leu Pro Lys Lys 
        435                 440                 445             


Val Met Lys Gly Val Ala Asp Ser Gly Pro Leu Tyr Gln Tyr Trp Gly 
    450                 455                 460                 


Arg Thr Glu Lys Val Met Phe Gly Met Ala Cys Leu Ile Cys Asn Arg 
465                 470                 475                 480 


Lys Glu Asp Tyr Pro Leu Leu Gly Arg Asn Lys Glu Ile Asn Tyr Phe 
                485                 490                 495     


Met Tyr Thr Met Lys Lys Phe Leu Ile Ser Asn Ser Ser Gln Val Leu 
            500                 505                 510         


Met Tyr Glu Gly Leu Pro Gly Tyr Gly Lys Ser Gln Ile Leu Met Lys 
        515                 520                 525             


Ile Glu Tyr Leu Ala Gln Gly Lys Asn His Arg Ile Ile Ala Ile Ser 
    530                 535                 540                 


Leu Asn Lys Ile Ser Phe His Gln Thr Phe Tyr Thr Ile Gln Met Phe 
545                 550                 555                 560 


Met Ala Asn Val Leu Gly Leu Asp Thr Cys Lys His Tyr Lys Glu Arg 
                565                 570                 575     


Gln Thr Asn Leu Arg Asn Lys Val Met Thr Leu Leu Asp Glu Lys Phe 
            580                 585                 590         


Tyr Cys Leu Leu Asn Asp Ile Phe His Val Gln Phe Pro Ile Ser Arg 
        595                 600                 605             


Glu Ile Ser Arg Met Ser Thr Leu Lys Lys Gln Lys Gln Leu Glu Ile 
    610                 615                 620                 


Leu Phe Met Lys Ile Leu Lys Leu Ile Val Lys Glu Glu Arg Ile Ile 
625                 630                 635                 640 


Phe Ile Ile Asp Glu Ala Gln Phe Val Asp Ser Thr Ser Trp Arg Phe 
                645                 650                 655     


Met Glu Lys Leu Ile Arg Thr Leu Pro Ile Phe Ile Ile Met Ser Leu 
            660                 665                 670         


Cys Pro Phe Val Asn Ile Pro Cys Ala Ala Ala Arg Ala Val Ile Lys 
        675                 680                 685             


Asn Arg Asn Thr Thr Tyr Ile Val Ile Gly Ala Val Gln Pro Asn Asp 
    690                 695                 700                 


Ile Ser Asn Lys Ile Cys Leu Asp Leu Asn Val Ser Cys Ile Ser Lys 
705                 710                 715                 720 


Glu Leu Asp Ser Tyr Leu Gly Glu Gly Ser Cys Gly Ile Pro Phe Tyr 
                725                 730                 735     


Cys Glu Glu Leu Leu Lys Asn Leu Glu His His Glu Val Leu Val Phe 
            740                 745                 750         


Gln Gln Thr Glu Ser Glu Glu Lys Thr Asn Arg Thr Trp Asn Asn Leu 
        755                 760                 765             


Phe Lys Tyr Ser Ile Lys Leu Thr Glu Lys Leu Asn Met Val Thr Leu 
    770                 775                 780                 


His Ser Asp Lys Glu Ser Glu Glu Val Cys His Leu Thr Ser Gly Val 
785                 790                 795                 800 


Arg Leu Lys Asn Leu Ser Pro Pro Thr Ser Leu Lys Glu Ile Ser Leu 
                805                 810                 815     


Ile Gln Leu Asp Ser Met Arg Leu Ser His Gln Met Leu Val Arg Cys 
            820                 825                 830         


Ala Ala Ile Ile Gly Leu Thr Phe Thr Thr Glu Leu Leu Phe Glu Ile 
        835                 840                 845             


Leu Pro Cys Trp Asn Met Lys Met Met Ile Lys Thr Leu Ala Thr Leu 
    850                 855                 860                 


Val Glu Ser Asn Ile Phe Tyr Cys Phe Arg Asn Gly Lys Glu Leu Gln 
865                 870                 875                 880 


Lys Ala Leu Lys Gln Asn Asp Pro Ser Phe Glu Val His Tyr Arg Ser 
                885                 890                 895     


Leu Ser Leu Lys Pro Ser Glu Gly Met Asp His Gly Glu Glu Glu Gln 
            900                 905                 910         


Leu Arg Glu Leu Glu Asn Glu Val Ile Glu Cys His Arg Ile Arg Phe 
        915                 920                 925             


Cys Asn Pro Met Met Gln Lys Thr Ala Tyr Glu Leu Trp Leu Lys Asp 
    930                 935                 940                 


Gln Arg Lys Ala Met His Leu Lys Cys Ala Arg Phe Leu Glu Glu Asp 
945                 950                 955                 960 


Ala His Arg Cys Asp His Cys Arg Gly Arg Asp Phe Ile Pro Tyr His 
                965                 970                 975     


His Phe Thr Val Asn Ile Arg Leu Asn Ala Leu Asp Met Asp Ala Ile 
            980                 985                 990         


Lys Lys Met Ala Met Ser His Gly  Phe Lys Thr Glu Glu  Lys Leu Ile 
        995                 1000                 1005             


Leu Ser  Asn Ser Glu Ile Pro  Glu Thr Ser Ala Phe  Phe Pro Glu 
    1010                 1015                 1020             


Asn Arg  Ser Pro Glu Glu Ile  Arg Glu Lys Ile Leu  Asn Phe Phe 
    1025                 1030                 1035             


Asp His  Val Leu Thr Lys Met  Lys Thr Ser Asp Glu  Asp Ile Ile 
    1040                 1045                 1050             


Pro Leu  Glu Ser Cys Gln Cys  Glu Glu Ile Leu Glu  Ile Val Ile 
    1055                 1060                 1065             


Leu Pro  Leu Ala His His Phe  Leu Ala Leu Gly Glu  Asn Asp Lys 
    1070                 1075                 1080             


Ala Leu  Tyr Tyr Phe Leu Glu  Ile Ala Ser Ala Tyr  Leu Ile Phe 
    1085                 1090                 1095             


Cys Asp  Asn Tyr Met Ala Tyr  Met Tyr Leu Asn Glu  Gly Gln Lys 
    1100                 1105                 1110             


Leu Leu  Lys Thr Leu Lys Lys  Asp Lys Ser Trp Ser  Gln Thr Phe 
    1115                 1120                 1125             


Glu Ser  Ala Thr Phe Tyr Ser  Leu Lys Gly Glu Val  Cys Phe Asn 
    1130                 1135                 1140             


Met Gly  Gln Ile Val Leu Ala  Lys Lys Met Leu Arg  Lys Ala Leu 
    1145                 1150                 1155             


Lys Leu  Leu Asn Arg Ile Phe  Pro Tyr Asn Leu Ile  Ser Leu Phe 
    1160                 1165                 1170             


Leu His  Ile His Val Glu Lys  Asn Arg His Phe His  Tyr Val Asn 
    1175                 1180                 1185             


Arg Gln  Ala Gln Glu Ser Pro  Pro Pro Gly Lys Lys  Arg Leu Ala 
    1190                 1195                 1200             


Gln Leu  Tyr Arg Gln Thr Val  Cys Leu Ser Leu Leu  Trp Arg Ile 
    1205                 1210                 1215             


Tyr Ser  Tyr Ser Tyr Leu Phe  His Cys Lys Tyr Tyr  Ala His Leu 
    1220                 1225                 1230             


Ala Val  Met Met Gln Met Asn  Thr Ala Leu Glu Thr  Gln Asn Cys 
    1235                 1240                 1245             


Phe Gln  Ile Ile Lys Ala Tyr  Leu Asp Tyr Ser Leu  Tyr His His 
    1250                 1255                 1260             


Leu Ala  Gly Tyr Lys Gly Val  Trp Phe Lys Tyr Glu  Val Met Ala 
    1265                 1270                 1275             


Met Glu  His Ile Phe Asn Leu  Pro Leu Lys Gly Glu  Gly Ile Glu 
    1280                 1285                 1290             


Ile Val  Ala Tyr Val Ala Glu  Thr Leu Val Phe Asn  Lys Leu Ile 
    1295                 1300                 1305             


Met Gly  His Leu Asp Leu Ala  Ile Glu Leu Gly Ser  Arg Ala Leu 
    1310                 1315                 1320             


Gln Met  Trp Ala Leu Leu Gln  Asn Pro Asn Arg His  Tyr Gln Ser 
    1325                 1330                 1335             


Leu Cys  Arg Leu Ser Arg Cys  Leu Leu Leu Asn Ser  Arg Tyr Pro 
    1340                 1345                 1350             


Gln Leu  Ile Gln Val Leu Gly  Arg Leu Trp Glu Leu  Ser Val Thr 
    1355                 1360                 1365             


Gln Glu  His Ile Phe Ser Lys  Ala Phe Phe Tyr Phe  Val Cys Leu 
    1370                 1375                 1380             


Asp Ile  Leu Leu Tyr Ser Gly  Phe Val Tyr Arg Thr  Phe Glu Glu 
    1385                 1390                 1395             


Cys Leu  Glu Phe Ile His Gln  Tyr Glu Asn Asn Arg  Ile Leu Lys 
    1400                 1405                 1410             


Phe His  Ser Gly Leu Leu Leu  Gly Leu Tyr Ser Ser  Val Ala Ile 
    1415                 1420                 1425             


Trp Tyr  Ala Arg Leu Gln Glu  Trp Asp Asn Phe Tyr  Lys Phe Ser 
    1430                 1435                 1440             


Asn Arg  Ala Lys Asn Leu Leu  Pro Arg Arg Thr Met  Thr Leu Thr 
    1445                 1450                 1455             


Tyr Tyr  Asp Gly Ile Ser Arg  Tyr Met Glu Gly Gln  Val Leu His 
    1460                 1465                 1470             


Leu Gln  Lys Gln Ile Lys Glu  Gln Ser Glu Asn Ala  Gln Ala Ser 
    1475                 1480                 1485             


Gly Glu  Glu Leu Leu Lys Asn  Leu Glu Asn Leu Val  Ala Gln Asn 
    1490                 1495                 1500             


Thr Thr  Gly Pro Val Phe Cys  Pro Arg Leu Tyr His  Leu Met Ala 
    1505                 1510                 1515             


Tyr Val  Cys Ile Leu Met Gly  Asp Gly Gln Lys Cys  Gly Leu Phe 
    1520                 1525                 1530             


Leu Asn  Thr Ala Leu Arg Leu  Ser Glu Thr Gln Gly  Asn Ile Leu 
    1535                 1540                 1545             


Glu Lys  Cys Trp Leu Asn Met  Asn Lys Glu Ser Trp  Tyr Ser Thr 
    1550                 1555                 1560             


Ser Glu  Leu Lys Glu Asp Gln  Trp Leu Gln Thr Ile  Leu Ser Leu 
    1565                 1570                 1575             


Pro Ser  Trp Glu Lys Ile Val  Ala Gly Arg Val Asn  Ile Gln Asp 
    1580                 1585                 1590             


Leu Gln  Lys Asn Lys Phe Leu  Met Arg Ala Asn Thr  Val Asp Asn 
    1595                 1600                 1605             


His Phe  
    1610 


<210>  4446
<211>  547
<212>  PRT
<213>  Homo sapiens

<400>  4446

Met Glu Val Glu Glu Ala Phe Gln Ala Val Gly Glu Met Gly Ile Tyr 
1               5                   10                  15      


Gln Met Tyr Leu Cys Phe Leu Leu Ala Val Leu Leu Gln Leu Tyr Val 
            20                  25                  30          


Ala Thr Glu Ala Ile Leu Ile Ala Leu Val Gly Ala Thr Pro Ser Tyr 
        35                  40                  45              


His Trp Asp Leu Ala Glu Leu Leu Pro Asn Gln Ser His Gly Asn Gln 
    50                  55                  60                  


Ser Ala Gly Glu Asp Gln Ala Phe Gly Asp Trp Leu Leu Thr Ala Asn 
65                  70                  75                  80  


Gly Ser Glu Ile His Lys His Val His Phe Ser Ser Ser Phe Thr Ser 
                85                  90                  95      


Ile Ala Ser Glu Trp Phe Leu Ile Ala Asn Arg Ser Tyr Lys Val Ser 
            100                 105                 110         


Ala Ala Ser Ser Phe Phe Phe Ser Gly Val Phe Val Gly Val Ile Ser 
        115                 120                 125             


Phe Gly Gln Leu Ser Asp Arg Phe Gly Arg Lys Lys Val Tyr Leu Thr 
    130                 135                 140                 


Gly Phe Ala Leu Asp Ile Leu Phe Ala Ile Ala Asn Gly Phe Ser Pro 
145                 150                 155                 160 


Ser Tyr Glu Phe Phe Ala Val Thr Arg Phe Leu Val Gly Met Met Asn 
                165                 170                 175     


Gly Gly Met Ser Leu Val Ala Phe Val Leu Leu Asn Glu Cys Val Gly 
            180                 185                 190         


Thr Ala Tyr Trp Ala Leu Ala Gly Ser Ile Gly Gly Leu Phe Phe Ala 
        195                 200                 205             


Val Gly Ile Ala Gln Tyr Ala Leu Leu Gly Tyr Phe Ile Arg Ser Trp 
    210                 215                 220                 


Arg Thr Leu Ala Ile Leu Val Asn Leu Gln Gly Thr Val Val Phe Leu 
225                 230                 235                 240 


Leu Ser Leu Phe Ile Pro Glu Ser Pro Arg Trp Leu Tyr Ser Gln Gly 
                245                 250                 255     


Arg Leu Ser Glu Ala Glu Glu Ala Leu Tyr Leu Ile Ala Lys Arg Asn 
            260                 265                 270         


Arg Lys Leu Lys Cys Thr Phe Ser Leu Thr His Pro Ala Asn Arg Ser 
        275                 280                 285             


Cys Arg Glu Thr Gly Ser Phe Leu Asp Leu Phe Arg Tyr Arg Val Leu 
    290                 295                 300                 


Leu Gly His Thr Leu Ile Leu Met Phe Ile Trp Phe Val Cys Ser Leu 
305                 310                 315                 320 


Val Tyr Tyr Gly Leu Thr Leu Ser Ala Gly Asp Leu Gly Gly Ser Ile 
                325                 330                 335     


Tyr Ala Asn Leu Ala Leu Ser Gly Leu Ile Glu Ile Pro Ser Tyr Pro 
            340                 345                 350         


Leu Cys Ile Tyr Leu Ile Asn Gln Lys Trp Phe Gly Arg Lys Arg Thr 
        355                 360                 365             


Leu Ser Ala Phe Leu Cys Leu Gly Gly Leu Ala Cys Leu Ile Val Met 
    370                 375                 380                 


Phe Leu Pro Glu Lys Lys Asp Thr Gly Val Phe Ala Val Val Asn Ser 
385                 390                 395                 400 


His Ser Leu Ser Leu Leu Gly Lys Leu Thr Ile Ser Ala Ala Phe Asn 
                405                 410                 415     


Ile Val Tyr Ile Tyr Thr Ser Glu Leu Tyr Pro Thr Val Ile Arg Asn 
            420                 425                 430         


Val Gly Leu Gly Thr Cys Ser Met Phe Ser Arg Val Gly Gly Ile Ile 
        435                 440                 445             


Ala Pro Phe Ile Pro Ser Leu Lys Tyr Val Gln Trp Ser Leu Pro Phe 
    450                 455                 460                 


Ile Val Phe Gly Ala Thr Gly Leu Thr Ser Gly Leu Leu Ser Leu Leu 
465                 470                 475                 480 


Leu Pro Glu Thr Leu Asn Ser Pro Leu Leu Glu Thr Phe Ser Asp Leu 
                485                 490                 495     


Gln Val Tyr Ser Tyr Arg Arg Leu Gly Glu Glu Ala Leu Ser Leu Gln 
            500                 505                 510         


Ala Leu Asp Pro Gln Gln Cys Val Asp Lys Glu Ser Ser Leu Gly Ser 
        515                 520                 525             


Glu Ser Glu Glu Glu Glu Glu Phe Tyr Asp Ala Asp Glu Glu Thr Gln 
    530                 535                 540                 


Met Ile Lys 
545         


<210>  4447
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  4447

Met Gly Met Thr Arg Met Leu Leu Glu Cys Ser Leu Ser Asp Lys Leu 
1               5                   10                  15      


Cys Val Ile Gln Glu Lys Gln Tyr Glu Val Ile Ile Val Pro Thr Leu 
            20                  25                  30          


Leu Val Thr Ile Phe Leu Ile Leu Leu Gly Val Ile Leu Trp Leu Phe 
        35                  40                  45              


Ile Arg Glu Gln Arg Thr Gln Gln Gln Arg Ser Gly Pro Gln Gly Ile 
    50                  55                  60                  


Ala Pro Val Pro Pro Pro Arg Asp Leu Ser Trp Glu Ala Gly His Gly 
65                  70                  75                  80  


Gly Asn Val Ala Leu Pro Leu Lys Glu Thr Ser Val Glu Asn Phe Leu 
                85                  90                  95      


Gly Ala Thr Thr Pro Ala Leu Ala Lys Leu Gln Val Pro Arg Glu Gln 
            100                 105                 110         


Leu Ser Glu Val Leu Glu Gln Ile Cys Ser Gly Ser Cys Gly Pro Ile 
        115                 120                 125             


Phe Arg Ala Asn Met Asn Thr Gly Asp Pro Ser Lys Pro Lys Ser Val 
    130                 135                 140                 


Ile Leu Lys Ala Leu Lys Glu Pro Ala Gly Leu His Glu Val Gln Asp 
145                 150                 155                 160 


Phe Leu Gly Arg Ile Gln Phe His Gln Tyr Leu Gly Lys His Lys Asn 
                165                 170                 175     


Leu Val Gln Leu Glu Gly Cys Cys Thr Glu Lys Leu Pro Leu Tyr Met 
            180                 185                 190         


Val Leu Glu Asp Val Ala Gln Gly Asp Leu Leu Ser Phe Leu Trp Thr 
        195                 200                 205             


Cys Arg Arg Asp Val Met Thr Met Asp Gly Leu Leu Tyr Asp Leu Thr 
    210                 215                 220                 


Glu Lys Gln Val Tyr His Ile Gly Lys Gln Val Leu Leu Ala Leu Glu 
225                 230                 235                 240 


Phe Leu Gln Glu Lys His Leu Phe His Gly Asp Val Ala Ala Arg Asn 
                245                 250                 255     


Ile Leu Met Gln Ser Asp Leu Thr Ala Lys Leu Cys Gly Leu Gly Leu 
            260                 265                 270         


Ala Tyr Glu Val Tyr Thr Arg Gly Ala Ile Ser Ser Thr Gln Thr Ile 
        275                 280                 285             


Pro Leu Lys Trp Leu Ala Pro Glu Arg Leu Leu Leu Arg Pro Ala Ser 
    290                 295                 300                 


Ile Arg Ala Asp Val Trp Ser Phe Gly Ile Leu Leu Tyr Glu Met Val 
305                 310                 315                 320 


Thr Leu Gly Ala Pro Pro Tyr Pro Glu Val Pro Pro Thr Ser Ile Leu 
                325                 330                 335     


Glu His Leu Gln Arg Arg Lys Ile Met Lys Arg Pro Ser Ser Cys Thr 
            340                 345                 350         


His Thr Met Tyr Ser Ile Met Lys Ser Cys Trp Arg Trp Arg Glu Ala 
        355                 360                 365             


Asp Arg Pro Ser Pro Arg Glu Leu Arg Leu Arg Leu Glu Ala Ala Ile 
    370                 375                 380                 


Lys Thr Ala Asp Asp Glu Ala Val Leu Gln Val Pro Glu Leu Val Val 
385                 390                 395                 400 


Pro Glu Leu Tyr Ala Ala Val Ala Gly Ile Arg Val Glu Ser Leu Phe 
                405                 410                 415     


Tyr Asn Tyr Ser Met Leu 
            420         


<210>  4448
<211>  832
<212>  PRT
<213>  Homo sapiens

<400>  4448

Met Leu Pro Phe Leu Leu Ala Thr Leu Gly Thr Thr Ala Leu Asn Asn 
1               5                   10                  15      


Ser Asn Pro Lys Asp Tyr Cys Tyr Ser Ala Arg Ile Arg Ser Thr Val 
            20                  25                  30          


Leu Gln Gly Leu Pro Phe Gly Gly Val Pro Thr Val Leu Ala Leu Asp 
        35                  40                  45              


Phe Met Cys Phe Leu Ala Leu Leu Phe Leu Phe Ser Ile Leu Arg Lys 
    50                  55                  60                  


Val Ala Trp Asp Tyr Gly Arg Leu Ala Leu Val Thr Asp Ala Asp Arg 
65                  70                  75                  80  


Leu Arg Arg Gln Glu Arg Asp Arg Val Glu Gln Glu Tyr Val Ala Ser 
                85                  90                  95      


Ala Met His Gly Asp Ser His Asp Arg Tyr Glu Arg Leu Thr Ser Val 
            100                 105                 110         


Ser Ser Ser Val Asp Phe Asp Gln Arg Asp Asn Gly Phe Cys Ser Trp 
        115                 120                 125             


Leu Thr Ala Ile Phe Arg Ile Lys Asp Asp Glu Ile Arg Asp Lys Cys 
    130                 135                 140                 


Gly Gly Asp Ala Val His Tyr Leu Ser Phe Gln Arg His Ile Ile Gly 
145                 150                 155                 160 


Leu Leu Val Val Val Gly Val Leu Ser Val Gly Ile Val Leu Pro Val 
                165                 170                 175     


Asn Phe Ser Gly Asp Leu Leu Glu Asn Asn Ala Tyr Ser Phe Gly Arg 
            180                 185                 190         


Thr Thr Ile Ala Asn Leu Lys Ser Gly Asn Asn Leu Leu Trp Leu His 
        195                 200                 205             


Thr Ser Phe Ala Phe Leu Tyr Leu Leu Leu Thr Val Tyr Ser Met Arg 
    210                 215                 220                 


Arg His Thr Ser Lys Met Arg Tyr Lys Glu Asp Asp Leu Val Lys Arg 
225                 230                 235                 240 


Thr Leu Phe Ile Asn Gly Ile Ser Lys Tyr Ala Glu Ser Glu Lys Ile 
                245                 250                 255     


Lys Lys His Phe Glu Glu Ala Tyr Pro Asn Cys Thr Val Leu Glu Ala 
            260                 265                 270         


Arg Pro Cys Tyr Asn Val Ala Arg Leu Met Phe Leu Asp Ala Glu Arg 
        275                 280                 285             


Lys Lys Ala Glu Arg Gly Lys Leu Tyr Phe Thr Asn Leu Gln Ser Lys 
    290                 295                 300                 


Glu Asn Val Pro Thr Met Ile Asn Pro Lys Pro Cys Gly His Leu Cys 
305                 310                 315                 320 


Cys Cys Val Val Arg Gly Cys Glu Gln Val Glu Ala Ile Glu Tyr Tyr 
                325                 330                 335     


Thr Lys Leu Glu Gln Lys Leu Lys Glu Asp Tyr Lys Arg Glu Lys Glu 
            340                 345                 350         


Lys Val Asn Glu Lys Pro Leu Gly Met Ala Phe Val Thr Phe His Asn 
        355                 360                 365             


Glu Thr Ile Thr Ala Ile Ile Leu Lys Asp Phe Asn Val Cys Lys Cys 
    370                 375                 380                 


Gln Gly Cys Thr Cys Arg Gly Glu Pro Arg Pro Ser Ser Cys Ser Glu 
385                 390                 395                 400 


Ser Leu His Ile Ser Asn Trp Thr Val Ser Tyr Ala Pro Asp Pro Gln 
                405                 410                 415     


Asn Ile Tyr Trp Glu His Leu Ser Ile Arg Gly Phe Ile Trp Trp Leu 
            420                 425                 430         


Arg Cys Leu Val Ile Asn Val Val Leu Phe Ile Leu Leu Phe Phe Leu 
        435                 440                 445             


Thr Thr Pro Ala Ile Ile Ile Thr Thr Met Asp Lys Phe Asn Val Thr 
    450                 455                 460                 


Lys Pro Val Glu Tyr Leu Asn Asn Pro Ile Ile Thr Gln Phe Phe Pro 
465                 470                 475                 480 


Thr Leu Leu Leu Trp Cys Phe Ser Ala Leu Leu Pro Thr Ile Val Tyr 
                485                 490                 495     


Tyr Ser Ala Phe Phe Glu Ala His Trp Thr Arg Ser Gly Glu Asn Arg 
            500                 505                 510         


Thr Thr Met His Lys Cys Tyr Thr Phe Leu Ile Phe Met Val Leu Leu 
        515                 520                 525             


Leu Pro Ser Leu Gly Leu Ser Ser Leu Asp Leu Phe Phe Arg Trp Leu 
    530                 535                 540                 


Phe Asp Lys Lys Phe Leu Ala Glu Ala Ala Ile Arg Phe Glu Cys Val 
545                 550                 555                 560 


Phe Leu Pro Asp Asn Gly Ala Phe Phe Val Asn Tyr Val Ile Ala Ser 
                565                 570                 575     


Ala Phe Ile Gly Asn Ala Met Asp Leu Leu Arg Ile Pro Gly Leu Leu 
            580                 585                 590         


Met Tyr Met Ile Arg Leu Cys Leu Ala Arg Ser Ala Ala Glu Arg Arg 
        595                 600                 605             


Asn Val Lys Arg His Gln Ala Tyr Glu Phe Gln Phe Gly Ala Ala Tyr 
    610                 615                 620                 


Ala Trp Met Met Cys Val Phe Thr Val Val Met Thr Tyr Ser Ile Thr 
625                 630                 635                 640 


Cys Pro Ile Ile Val Pro Phe Gly Leu Met Tyr Met Leu Leu Lys His 
                645                 650                 655     


Leu Val Asp Arg Tyr Asn Leu Tyr Tyr Ala Tyr Leu Pro Ala Lys Leu 
            660                 665                 670         


Asp Lys Lys Ile His Ser Gly Ala Val Asn Gln Val Val Ala Ala Pro 
        675                 680                 685             


Ile Leu Cys Leu Phe Trp Leu Leu Phe Phe Ser Thr Met Arg Thr Gly 
    690                 695                 700                 


Phe Leu Ala Pro Thr Ser Met Phe Thr Phe Val Val Leu Val Ile Thr 
705                 710                 715                 720 


Ile Val Ile Cys Leu Cys His Val Cys Phe Gly His Phe Lys Tyr Leu 
                725                 730                 735     


Ser Ala His Asn Tyr Lys Ile Glu His Thr Glu Thr Asp Thr Val Asp 
            740                 745                 750         


Pro Arg Ser Asn Gly Arg Pro Pro Thr Ala Ala Ala Val Pro Lys Ser 
        755                 760                 765             


Ala Lys Tyr Ile Ala Gln Val Leu Gln Asp Ser Glu Val Asp Gly Asp 
    770                 775                 780                 


Gly Asp Gly Ala Pro Gly Ser Ser Gly Asp Glu Pro Pro Ser Ser Ser 
785                 790                 795                 800 


Ser Gln Asp Glu Glu Leu Leu Met Pro Pro Asp Ala Leu Thr Asp Thr 
                805                 810                 815     


Asp Phe Gln Ser Cys Glu Asp Ser Leu Ile Glu Asn Glu Ile His Gln 
            820                 825                 830         


<210>  4449
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  4449

Met Ser Cys Ala Gly Arg Ala Gly Pro Ala Arg Leu Ala Ala Leu Ala 
1               5                   10                  15      


Leu Leu Thr Cys Ser Leu Trp Pro Ala Arg Ala Asp Asn Ala Ser Gln 
            20                  25                  30          


Glu Tyr Tyr Thr Ala Leu Ile Asn Val Thr Val Gln Glu Pro Gly Arg 
        35                  40                  45              


Gly Ala Pro Leu Thr Phe Arg Ile Asp Arg Gly Arg Tyr Gly Leu Asp 
    50                  55                  60                  


Ser Pro Lys Ala Glu Val Arg Gly Gln Val Leu Ala Pro Leu Pro Leu 
65                  70                  75                  80  


His Gly Val Ala Asp His Leu Gly Cys Asp Pro Gln Thr Arg Phe Phe 
                85                  90                  95      


Val Pro Pro Asn Ile Lys Gln Trp Ile Ala Leu Leu Gln Arg Gly Asn 
            100                 105                 110         


Cys Thr Phe Lys Glu Lys Ile Ser Arg Ala Ala Phe His Asn Ala Val 
        115                 120                 125             


Ala Val Val Ile Tyr Asn Asn Lys Ser Lys Glu Glu Pro Val Thr Met 
    130                 135                 140                 


Thr His Pro Gly Thr Gly Asp Ile Ile Ala Val Met Ile Thr Glu Leu 
145                 150                 155                 160 


Arg Gly Lys Asp Ile Leu Ser Tyr Leu Glu Lys Asn Ile Ser Val Gln 
                165                 170                 175     


Met Thr Ile Ala Val Gly Thr Arg Met Pro Pro Lys Asn Phe Ser Arg 
            180                 185                 190         


Gly Ser Leu Val Phe Val Ser Ile Ser Phe Ile Val Leu Met Ile Ile 
        195                 200                 205             


Ser Ser Ala Trp Leu Ile Phe Tyr Phe Ile Gln Lys Ile Arg Tyr Thr 
    210                 215                 220                 


Asn Ala Arg Asp Arg Asn Gln Arg Arg Leu Gly Asp Ala Ala Lys Lys 
225                 230                 235                 240 


Ala Ile Ser Lys Leu Thr Thr Arg Thr Val Lys Lys Gly Asp Lys Glu 
                245                 250                 255     


Thr Asp Pro Asp Phe Asp His Cys Ala Val Cys Ile Glu Ser Tyr Lys 
            260                 265                 270         


Gln Asn Asp Val Val Arg Ile Leu Pro Cys Lys His Val Phe His Lys 
        275                 280                 285             


Ser Cys Val Asp Pro Trp Leu Ser Glu His Cys Thr Cys Pro Met Cys 
    290                 295                 300                 


Lys Leu Asn Ile Leu Lys Ala Leu Gly Ile Val Pro Asn Leu Pro Cys 
305                 310                 315                 320 


Thr Asp Asn Val Ala Phe Asp Met Glu Arg Leu Thr Arg Thr Gln Ala 
                325                 330                 335     


Val Asn Arg Arg Ser Ala Leu Gly Asp Leu Ala Gly Asp Asn Ser Leu 
            340                 345                 350         


Gly Leu Glu Pro Leu Arg Thr Ser Gly Ile Ser Pro Leu Pro Gln Asp 
        355                 360                 365             


Gly Glu Leu Thr Pro Arg Thr Gly Glu Ile Asn Ile Ala Val Thr Lys 
    370                 375                 380                 


Glu Trp Phe Ile Ile Ala Ser Phe Gly Leu Leu Ser Ala Leu Thr Leu 
385                 390                 395                 400 


Cys Tyr Met Ile Ile Arg Ala Thr Ala Ser Leu Asn Ala Asn Glu Val 
                405                 410                 415     


Glu Trp Phe 
            


<210>  4450
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  4450

Met Gly Pro Ala Gly Ser Leu Leu Gly Ser Gly Gln Met Gln Ile Thr 
1               5                   10                  15      


Leu Trp Gly Ser Leu Ala Ala Val Ala Ile Phe Phe Val Ile Thr Phe 
            20                  25                  30          


Leu Ile Phe Leu Cys Ser Ser Cys Asp Arg Glu Lys Lys Pro Arg Gln 
        35                  40                  45              


His Ser Gly Asp His Glu Asn Leu Met Asn Val Pro Ser Asp Lys Glu 
    50                  55                  60                  


Met Phe Ser Arg Ser Val Thr Ser Leu Ala Thr Asp Ala Pro Ala Ser 
65                  70                  75                  80  


Ser Glu Gln Asn Gly Ala Leu Thr Asn Gly Asp Ile Leu Ser Glu Asp 
                85                  90                  95      


Ser Thr Leu Thr Cys Met Gln His Tyr Glu Glu Val Gln Thr Ser Ala 
            100                 105                 110         


Ser Asp Leu Leu Asp Ser Gln Asp Ser Thr Gly Lys Pro Lys Cys His 
        115                 120                 125             


Gln Ser Arg Glu Leu Pro Arg Ile Pro Pro Glu Ser Ala Val Asp Thr 
    130                 135                 140                 


Met Leu Thr Ala Arg Ser Val Asp Gly Asp Gln Gly Leu Gly Met Glu 
145                 150                 155                 160 


Gly Pro Tyr Glu Val Leu Lys Asp Ser Ser Ser Gln Glu Asn Met Val 
                165                 170                 175     


Glu Asp Cys Leu Tyr Glu Thr Val Lys Glu Ile Lys Glu Val Ala Ala 
            180                 185                 190         


Ala Ala His Leu Glu Lys Gly His Ser Gly Lys Ala Lys Ser Thr Ser 
        195                 200                 205             


Ala Ser Lys Glu Leu Pro Gly Pro Gln Thr Glu Gly Lys Ala Glu Phe 
    210                 215                 220                 


Ala Glu Tyr Ala Ser Val Asp Arg Asn Lys Lys Cys Arg Gln Ser Val 
225                 230                 235                 240 


Asn Val Glu Ser Ile Leu Gly Asn Ser Cys Asp Pro Glu Glu Glu Ala 
                245                 250                 255     


Pro Pro Pro Val Pro Val Lys Leu Leu Asp Glu Asn Glu Asn Leu Gln 
            260                 265                 270         


Glu Lys Glu Gly Gly Glu Ala Glu Glu Ser Ala Thr Asp Thr Thr Ser 
        275                 280                 285             


Glu Thr Asn Lys Arg Phe Ser Ser Leu Ser Tyr Lys Ser Arg Glu Glu 
    290                 295                 300                 


Asp Pro Thr Leu Thr Glu Glu Glu Ile Ser Ala Met Tyr Ser Ser Val 
305                 310                 315                 320 


Asn Lys Pro Gly Gln Leu Val Asn Lys Ser Gly Gln Ser Leu Thr Val 
                325                 330                 335     


Pro Glu Ser Thr Tyr Thr Ser Ile Gln Gly Asp Pro Gln Arg Ser Pro 
            340                 345                 350         


Ser Ser Cys Asn Asp Leu Tyr Ala Thr Val Lys Asp Phe Glu Lys Thr 
        355                 360                 365             


Pro Asn Ser Thr Leu Pro Pro Ala Gly Arg Pro Ser Glu Glu Pro Glu 
    370                 375                 380                 


Pro Asp Tyr Glu Ala Ile Gln Thr Leu Asn Arg Glu Glu Glu Lys Ala 
385                 390                 395                 400 


Thr Leu Gly Thr Asn Gly His His Gly Leu Val Pro Lys Glu Asn Asp 
                405                 410                 415     


Tyr Glu Ser Ile Ser Asp Leu Gln Gln Gly Arg Asp Ile Thr Arg Leu 
            420                 425                 430         


<210>  4451
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  4451

Met Glu Arg Gln Glu Glu Ser Leu Ser Ala Arg Pro Ala Leu Glu Thr 
1               5                   10                  15      


Glu Gly Leu Arg Phe Leu His Thr Thr Val Gly Ser Leu Leu Ala Thr 
            20                  25                  30          


Tyr Gly Trp Tyr Ile Val Phe Ser Cys Ile Leu Leu Tyr Val Val Phe 
        35                  40                  45              


Gln Lys Leu Ser Ala Arg Leu Arg Ala Leu Arg Gln Arg Gln Leu Asp 
    50                  55                  60                  


Arg Ala Ala Ala Ala Val Glu Pro Asp Val Val Val Lys Arg Gln Glu 
65                  70                  75                  80  


Ala Leu Ala Ala Ala Arg Leu Lys Met Gln Glu Glu Leu Asn Ala Gln 
                85                  90                  95      


Val Glu Lys His Lys Glu Lys Leu Lys Gln Leu Glu Glu Glu Lys Arg 
            100                 105                 110         


Arg Gln Lys Ile Glu Met Trp Asp Ser Met Gln Glu Gly Lys Ser Tyr 
        115                 120                 125             


Lys Gly Asn Ala Lys Lys Pro Gln Glu Glu Asp Ser Pro Gly Pro Ser 
    130                 135                 140                 


Thr Ser Ser Val Leu Lys Arg Lys Ser Asp Arg Lys Pro Leu Arg Gly 
145                 150                 155                 160 


Gly Gly Tyr Asn Pro Leu Ser Gly Glu Gly Gly Gly Ala Cys Ser Trp 
                165                 170                 175     


Arg Pro Gly Arg Arg Gly Pro Ser Ser Gly Gly Gly 
            180                 185             


<210>  4452
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  4452

Met Ser Phe Arg Lys Val Asn Ile Ile Ile Leu Val Leu Ala Val Ala 
1               5                   10                  15      


Leu Phe Leu Leu Val Leu His His Asn Phe Leu Ser Leu Ser Ser Leu 
            20                  25                  30          


Leu Arg Asn Glu Val Thr Asp Ser Gly Ile Val Gly Pro Gln Pro Ile 
        35                  40                  45              


Asp Phe Val Pro Asn Ala Leu Arg His Ala Val Asp Gly Arg Gln Glu 
    50                  55                  60                  


Glu Ile Pro Val Val Ile Ala Ala Ser Glu Asp Arg Leu Gly Gly Ala 
65                  70                  75                  80  


Ile Ala Ala Ile Asn Ser Ile Gln His Asn Thr Arg Ser Asn Val Ile 
                85                  90                  95      


Phe Tyr Ile Val Thr Leu Asn Asn Thr Ala Asp His Leu Arg Ser Trp 
            100                 105                 110         


Leu Asn Ser Asp Ser Leu Lys Ser Ile Arg Tyr Lys Ile Val Asn Phe 
        115                 120                 125             


Asp Pro Lys Leu Leu Glu Gly Lys Val Lys Glu Asp Pro Asp Gln Gly 
    130                 135                 140                 


Glu Ser Met Lys Pro Leu Thr Phe Ala Arg Phe Tyr Leu Pro Ile Leu 
145                 150                 155                 160 


Val Pro Ser Ala Lys Lys Ala Ile Tyr Met Asp Asp Asp Val Ile Val 
                165                 170                 175     


Gln Gly Asp Ile Leu Ala Leu Tyr Asn Thr Ala Leu Lys Pro Gly His 
            180                 185                 190         


Ala Ala Ala Phe Ser Glu Asp Cys Asp Ser Ala Ser Thr Lys Val Val 
        195                 200                 205             


Ile Arg Gly Ala Gly Asn Gln Tyr Asn Tyr Ile Gly Tyr Leu Asp Tyr 
    210                 215                 220                 


Lys Lys Glu Arg Ile Arg Lys Leu Ser Met Lys Ala Ser Thr Cys Ser 
225                 230                 235                 240 


Phe Asn Pro Gly Val Phe Val Ala Asn Leu Thr Glu Trp Lys Arg Gln 
                245                 250                 255     


Asn Ile Thr Asn Gln Leu Glu Lys Trp Met Lys Leu Asn Val Glu Glu 
            260                 265                 270         


Gly Leu Tyr Ser Arg Thr Leu Ala Gly Ser Ile Thr Thr Pro Pro Leu 
        275                 280                 285             


Leu Ile Val Phe Tyr Gln Gln His Ser Thr Ile Asp Pro Met Trp Asn 
    290                 295                 300                 


Val Arg His Leu Gly Ser Ser Ala Gly Lys Arg Tyr Ser Pro Gln Phe 
305                 310                 315                 320 


Val Lys Ala Ala Lys Leu Leu His Trp Asn Gly His Leu Lys Pro Trp 
                325                 330                 335     


Gly Arg Thr Ala Ser Tyr Thr Asp Val Trp Glu Lys Trp Tyr Ile Pro 
            340                 345                 350         


Asp Pro Thr Gly Lys Phe Asn Leu Ile Arg Arg Tyr Thr Glu Ile Ser 
        355                 360                 365             


Asn Ile Lys 
    370     


<210>  4453
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  4453

Met Ala Gly Pro Glu Leu Leu Leu Asp Ser Asn Ile Arg Leu Trp Val 
1               5                   10                  15      


Val Leu Pro Ile Val Ile Ile Thr Phe Phe Val Gly Met Ile Arg His 
            20                  25                  30          


Tyr Val Ser Ile Leu Leu Gln Ser Asp Lys Lys Leu Thr Gln Glu Gln 
        35                  40                  45              


Val Ser Asp Ser Gln Val Leu Ile Arg Ser Arg Val Leu Arg Glu Asn 
    50                  55                  60                  


Gly Lys Tyr Ile Pro Lys Gln Ser Phe Leu Thr Arg Lys Tyr Tyr Phe 
65                  70                  75                  80  


Asn Asn Pro Glu Asp Gly Phe Phe Lys Lys Thr Lys Arg Lys Val Val 
                85                  90                  95      


Pro Pro Ser Pro Met Thr Asp Pro Thr Met Leu Thr Asp Met Met Lys 
            100                 105                 110         


Gly Asn Val Thr Asn Val Leu Pro Met Ile Leu Ile Gly Gly Trp Ile 
        115                 120                 125             


Asn Met Thr Phe Ser Gly Phe Val Thr Thr Lys Val Pro Phe Pro Leu 
    130                 135                 140                 


Thr Leu Arg Phe Lys Pro Met Leu Gln Gln Gly Ile Glu Leu Leu Thr 
145                 150                 155                 160 


Leu Asp Ala Ser Trp Val Ser Ser Ala Ser Trp Tyr Phe Leu Asn Val 
                165                 170                 175     


Phe Gly Leu Arg Ser Ile Tyr Ser Leu Ile Leu Gly Gln Asp Asn Ala 
            180                 185                 190         


Ala Asp Gln Ser Arg Met Met Gln Glu Gln Met Thr Gly Ala Ala Met 
        195                 200                 205             


Ala Met Pro Ala Asp Thr Asn Lys Ala Phe Lys Thr Glu Trp Glu Ala 
    210                 215                 220                 


Leu Glu Leu Thr Asp His Gln Trp Ala Leu Asp Asp Val Glu Glu Glu 
225                 230                 235                 240 


Leu Met Ala Lys Asp Leu His Phe Glu Gly Met Phe Lys Lys Glu Leu 
                245                 250                 255     


Gln Thr Ser Ile Phe 
            260     


<210>  4454
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  4454

Met Glu Thr Ala Gly Ala Ala Thr Gly Gln Pro Ala Ser Gly Leu Glu 
1               5                   10                  15      


Ala Pro Gly Ser Thr Asn Asp Arg Leu Phe Leu Val Lys Gly Gly Ile 
            20                  25                  30          


Phe Leu Gly Thr Val Ala Ala Ala Gly Met Leu Ala Gly Phe Ile Thr 
        35                  40                  45              


Thr Leu Ser Leu Ala Lys Lys Lys Ser Pro Glu Trp Phe Asn Lys Gly 
    50                  55                  60                  


Ser Met Ala Thr Ala Ala Leu Pro Glu Ser Gly Ser Ser Leu Ala Leu 
65                  70                  75                  80  


Arg Ala Leu Gly Trp Gly Ser Leu Tyr Ala Trp Cys Gly Val Gly Val 
                85                  90                  95      


Ile Ser Phe Ala Val Trp Lys Ala Leu Gly Val His Ser Met Asn Asp 
            100                 105                 110         


Phe Arg Ser Lys Met Gln Ser Ile Phe Pro Thr Ile Pro Lys Asn Ser 
        115                 120                 125             


Glu Ser Ala Val Glu Trp Glu Glu Thr Leu Lys Ser Lys 
    130                 135                 140     


<210>  4455
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  4455

Met Gly Phe Ile Phe Ser Lys Ser Met Asn Glu Ser Met Lys Asn Gln 
1               5                   10                  15      


Lys Glu Phe Met Leu Met Asn Ala Arg Leu Gln Leu Glu Arg Gln Leu 
            20                  25                  30          


Ile Met Gln Ser Glu Met Arg Glu Arg Gln Met Ala Met Gln Ile Ala 
        35                  40                  45              


Trp Ser Arg Glu Phe Leu Lys Tyr Phe Gly Thr Phe Phe Gly Leu Ala 
    50                  55                  60                  


Ala Ile Ser Leu Thr Ala Gly Ala Ile Lys Lys Lys Lys Pro Ala Phe 
65                  70                  75                  80  


Leu Val Pro Ile Val Pro Leu Ser Phe Ile Leu Thr Tyr Gln Tyr Asp 
                85                  90                  95      


Leu Gly Tyr Gly Thr Leu Leu Glu Arg Met Lys Gly Glu Ala Glu Asp 
            100                 105                 110         


Ile Leu Glu Thr Glu Lys Ser Lys Leu Gln Leu Pro Arg Gly Met Ile 
        115                 120                 125             


Thr Phe Glu Ser Ile Glu Lys Ala Arg Lys Glu Gln Ser Arg Phe Phe 
    130                 135                 140                 


Ile Asp Lys 
145         


<210>  4456
<211>  1134
<212>  PRT
<213>  Homo sapiens

<400>  4456

Met Thr Ser Leu Tyr Gly Arg His Ala Glu Lys Thr Thr Asp Met Pro 
1               5                   10                  15      


Lys Pro Ser Ala Pro Lys Val His Val Gln Arg Ser Val Ser Arg Asp 
            20                  25                  30          


Thr Ile Ala Ile His Phe Ser Ala Ser Gly Glu Glu Glu Glu Glu Glu 
        35                  40                  45              


Glu Glu Glu Phe Arg Glu Tyr Phe Glu Glu Gly Leu Asp Asp Gln Ser 
    50                  55                  60                  


Ile Val Thr Gly Leu Glu Ala Lys Glu Asp Leu Tyr Leu Glu Pro Gln 
65                  70                  75                  80  


Val Gly His Asp Pro Ala Gly Pro Ala Ala Ser Pro Val Leu Ala Asp 
                85                  90                  95      


Gly Leu Ser Val Ser Gln Ala Pro Ala Ile Leu Pro Val Ser Lys Asn 
            100                 105                 110         


Thr Val Lys Leu Leu Glu Ser Pro Val Pro Ala Ala Gln Val Leu Ser 
        115                 120                 125             


Thr Val Pro Leu Ala Val Ser Pro Gly Ser Ser Ser Ser Gly Pro Leu 
    130                 135                 140                 


Ala Ser Ser Pro Ser Val Ser Ser Leu Ser Glu Gln Lys Thr Ser Ser 
145                 150                 155                 160 


Ser Ser Pro Leu Ser Ser Pro Ser Lys Ser Pro Ile Leu Ser Ser Ser 
                165                 170                 175     


Ala Ser Thr Ser Thr Leu Ser Ser Ala Lys Pro Phe Met Ser Leu Val 
            180                 185                 190         


Lys Ser Leu Ser Thr Glu Val Glu Pro Lys Glu Ser Pro His Pro Ala 
        195                 200                 205             


Arg His Arg His Leu Met Lys Thr Leu Val Lys Ser Leu Ser Thr Asp 
    210                 215                 220                 


Thr Ser Arg Gln Glu Ser Asp Thr Val Ser Tyr Lys Pro Pro Asp Ser 
225                 230                 235                 240 


Lys Leu Asn Leu His Leu Phe Lys Gln Phe Thr Gln Pro Arg Asn Thr 
                245                 250                 255     


Gly Gly Asp Ser Lys Thr Ala Pro Ser Ser Pro Leu Thr Ser Pro Ser 
            260                 265                 270         


Asp Thr Arg Ser Phe Phe Lys Val Pro Glu Met Glu Ala Lys Ile Glu 
        275                 280                 285             


Asp Thr Lys Arg Arg Leu Ser Glu Val Ile Tyr Glu Pro Phe Gln Leu 
    290                 295                 300                 


Leu Ser Lys Ile Ile Gly Glu Glu Ser Gly Ser His Arg Pro Lys Ala 
305                 310                 315                 320 


Leu Ser Ser Ser Ala Ser Glu Leu Ser Asn Leu Ser Ser Leu Asn Gly 
                325                 330                 335     


His Leu Glu Ser Asn Asn Asn Tyr Ser Ile Lys Glu Glu Glu Cys Asp 
            340                 345                 350         


Ser Glu Gly Asp Gly Tyr Gly Ser Asp Ser Asn Ile Pro Arg Ser Asp 
        355                 360                 365             


His Pro Lys Ser Thr Gly Glu Pro Thr Arg Glu Ile Glu Leu Lys Ser 
    370                 375                 380                 


Ser Gln Gly Ser Ser Leu Lys Asp Leu Gly Leu Lys Thr Ser Ser Leu 
385                 390                 395                 400 


Val Leu Glu Lys Cys Ser Leu Ser Ala Leu Val Ser Lys Glu Asp Glu 
                405                 410                 415     


Glu Phe Cys Glu Leu Tyr Thr Glu Asp Phe Asp Leu Glu Thr Glu Gly 
            420                 425                 430         


Glu Ser Lys Val Asp Lys Leu Ser Asp Ile Pro Leu Lys Pro Glu Val 
        435                 440                 445             


Leu Ala Glu Asp Gly Val Val Leu Asp Ser Glu Asp Glu Val Asp Ser 
    450                 455                 460                 


Ala Val Gln His Pro Glu Leu Pro Val Lys Thr Leu Gly Phe Phe Ile 
465                 470                 475                 480 


Met Cys Val Tyr Val Tyr Leu Ile Leu Pro Leu Pro His Tyr Val Ser 
                485                 490                 495     


Gly Leu Phe Leu Gly Ile Gly Leu Gly Phe Met Thr Ala Val Cys Val 
            500                 505                 510         


Ile Trp Phe Phe Thr Pro Pro Ser Ala His Lys Tyr His Lys Leu His 
        515                 520                 525             


Lys Asn Leu Arg His Trp Asn Thr Arg Ser Leu Asp Ile Lys Glu Pro 
    530                 535                 540                 


Glu Ile Leu Lys Gly Trp Met Asn Glu Ile Tyr Asn Tyr Asp Pro Glu 
545                 550                 555                 560 


Thr Tyr His Ala Thr Leu Thr His Ser Val Phe Val Arg Leu Glu Gly 
                565                 570                 575     


Gly Thr Leu Arg Leu Ser Lys Pro Asn Lys Asn Ile Ser Arg Arg Ala 
            580                 585                 590         


Ser Tyr Asn Glu Pro Lys Pro Glu Val Thr Tyr Ile Ser Gln Lys Ile 
        595                 600                 605             


Tyr Asp Leu Ser Asp Ser Lys Ile Tyr Leu Val Pro Lys Thr Leu Ala 
    610                 615                 620                 


Arg Lys Arg Ile Trp Asn Lys Lys Tyr Pro Ile Cys Ile Glu Leu Gly 
625                 630                 635                 640 


Gln Gln Asp Asp Phe Met Ser Lys Ala Gln Thr Asp Lys Glu Thr Ser 
                645                 650                 655     


Glu Glu Lys Pro Pro Ala Glu Gly Ser Glu Asp Pro Lys Lys Pro Pro 
            660                 665                 670         


Arg Pro Gln Glu Gly Thr Arg Ser Ser Gln Arg Asp Gln Ile Leu Tyr 
        675                 680                 685             


Leu Phe Gly Arg Thr Gly Arg Glu Lys Glu Glu Trp Phe Arg Arg Phe 
    690                 695                 700                 


Ile Leu Ala Ser Lys Leu Lys Ser Glu Ile Lys Lys Ser Ser Gly Val 
705                 710                 715                 720 


Ser Gly Gly Lys Pro Ala Pro Val Phe Leu Ala Pro Gly Leu Leu Pro 
                725                 730                 735     


Ala His Ser Arg His Asn Ser Pro Ser Gly His Leu Thr His Ser Arg 
            740                 745                 750         


Ser Ser Ser Lys Gly Ser Val Glu Glu Ile Met Ser Gln Pro Lys Gln 
        755                 760                 765             


Lys Glu Leu Ala Gly Ser Val Arg Gln Lys Met Leu Leu Asp Tyr Ser 
    770                 775                 780                 


Val Tyr Met Gly Arg Cys Val Pro Gln Glu Ser Arg Ser Pro Gln Arg 
785                 790                 795                 800 


Ser Pro Leu Gln Ser Ala Glu Ser Ser Pro Thr Ala Gly Lys Lys Leu 
                805                 810                 815     


Pro Glu Val Pro Pro Ser Glu Glu Glu Glu Gln Glu Ala Trp Val Asn 
            820                 825                 830         


Ala Leu Leu Gly Arg Ile Phe Trp Asp Phe Leu Gly Glu Lys Tyr Trp 
        835                 840                 845             


Ser Asp Leu Val Ser Lys Lys Ile Gln Met Lys Leu Ser Lys Ile Lys 
    850                 855                 860                 


Leu Pro Tyr Phe Met Asn Glu Leu Thr Leu Thr Glu Leu Asp Met Gly 
865                 870                 875                 880 


Val Ala Val Pro Lys Ile Leu Gln Ala Phe Lys Pro Tyr Val Asp His 
                885                 890                 895     


Gln Gly Leu Trp Ile Asp Leu Glu Met Ser Tyr Asn Gly Ser Phe Leu 
            900                 905                 910         


Met Thr Leu Glu Thr Lys Met Asn Leu Thr Lys Leu Gly Lys Glu Pro 
        915                 920                 925             


Leu Val Glu Ala Leu Lys Val Gly Glu Ile Gly Lys Glu Gly Cys Arg 
    930                 935                 940                 


Pro Arg Ala Phe Cys Leu Ala Asp Ser Asp Glu Glu Ser Ser Ser Ala 
945                 950                 955                 960 


Gly Ser Ser Glu Glu Asp Asp Ala Pro Glu Pro Ser Gly Gly Asp Lys 
                965                 970                 975     


Gln Leu Leu Pro Gly Ala Glu Gly Tyr Val Gly Gly His Arg Thr Ser 
            980                 985                 990         


Lys Ile Met Arg Phe Val Asp Lys  Ile Thr Lys Ser Lys  Tyr Phe Gln 
        995                 1000                 1005             


Lys Ala  Thr Glu Thr Glu Phe  Ile Lys Lys Lys Ile  Glu Glu Val 
    1010                 1015                 1020             


Ser Asn  Thr Pro Leu Leu Leu  Thr Val Glu Val Gln  Glu Cys Arg 
    1025                 1030                 1035             


Gly Thr  Leu Ala Val Asn Ile  Pro Pro Pro Pro Thr  Asp Arg Val 
    1040                 1045                 1050             


Trp Tyr  Gly Phe Arg Lys Pro  Pro His Val Glu Leu  Lys Ala Arg 
    1055                 1060                 1065             


Pro Lys  Leu Gly Glu Arg Glu  Val Thr Leu Val His  Val Thr Asp 
    1070                 1075                 1080             


Trp Ile  Glu Lys Lys Leu Glu  Gln Glu Phe Gln Lys  Val Phe Val 
    1085                 1090                 1095             


Met Pro  Asn Met Asp Asp Val  Tyr Ile Thr Ile Met  His Ser Ala 
    1100                 1105                 1110             


Met Asp  Pro Arg Ser Thr Ser  Cys Leu Leu Lys Asp  Pro Pro Val 
    1115                 1120                 1125             


Glu Ala  Ala Asp Gln Pro 
    1130                 


<210>  4457
<211>  324
<212>  PRT
<213>  Homo sapiens

<400>  4457

Met Ala Ala Ala Ala Pro Gly Asn Gly Arg Ala Ser Ala Pro Arg Leu 
1               5                   10                  15      


Leu Leu Leu Phe Leu Val Pro Leu Leu Trp Ala Pro Ala Ala Val Arg 
            20                  25                  30          


Ala Gly Pro Asp Glu Asp Leu Ser His Arg Asn Lys Glu Pro Pro Ala 
        35                  40                  45              


Pro Ala Gln Gln Leu Gln Pro Gln Pro Val Ala Val Gln Gly Pro Glu 
    50                  55                  60                  


Pro Ala Arg Val Glu Lys Ile Phe Thr Pro Ala Ala Pro Val His Thr 
65                  70                  75                  80  


Asn Lys Glu Asp Pro Ala Thr Gln Thr Asn Leu Gly Phe Ile His Ala 
                85                  90                  95      


Phe Val Ala Ala Ile Ser Val Ile Ile Val Ser Glu Leu Gly Asp Lys 
            100                 105                 110         


Thr Phe Phe Ile Ala Ala Ile Met Ala Met Arg Tyr Asn Arg Leu Thr 
        115                 120                 125             


Val Leu Ala Gly Ala Met Leu Ala Leu Gly Leu Met Thr Cys Leu Ser 
    130                 135                 140                 


Val Leu Phe Gly Tyr Ala Thr Thr Val Ile Pro Arg Val Tyr Thr Tyr 
145                 150                 155                 160 


Tyr Val Ser Thr Val Leu Phe Ala Ile Phe Gly Ile Arg Met Leu Arg 
                165                 170                 175     


Glu Gly Leu Lys Met Ser Pro Asp Glu Gly Gln Glu Glu Leu Glu Glu 
            180                 185                 190         


Val Gln Ala Glu Leu Lys Lys Lys Asp Glu Glu Phe Gln Arg Thr Lys 
        195                 200                 205             


Leu Leu Asn Gly Pro Gly Asp Val Glu Thr Gly Thr Ser Ile Thr Val 
    210                 215                 220                 


Pro Gln Lys Lys Trp Leu His Phe Ile Ser Pro Ile Phe Val Gln Ala 
225                 230                 235                 240 


Leu Thr Leu Thr Phe Leu Ala Glu Trp Gly Asp Arg Ser Gln Leu Thr 
                245                 250                 255     


Thr Ile Val Leu Ala Ala Arg Glu Asp Pro Tyr Gly Val Ala Val Gly 
            260                 265                 270         


Gly Thr Val Gly His Cys Leu Cys Thr Gly Leu Ala Val Ile Gly Gly 
        275                 280                 285             


Arg Met Ile Ala Gln Lys Ile Ser Val Arg Thr Val Thr Ile Ile Gly 
    290                 295                 300                 


Gly Ile Val Phe Leu Ala Phe Ala Phe Ser Ala Leu Phe Ile Ser Pro 
305                 310                 315                 320 


Asp Ser Gly Phe 
                


<210>  4458
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  4458

Met Ala Lys Ser Leu Leu Lys Thr Ala Ser Leu Ser Gly Arg Thr Lys 
1               5                   10                  15      


Leu Leu His Gln Thr Gly Leu Ser Leu Tyr Ser Thr Ser His Gly Phe 
            20                  25                  30          


Tyr Glu Glu Glu Val Lys Lys Thr Leu Gln Gln Phe Pro Gly Gly Ser 
        35                  40                  45              


Ile Asp Leu Gln Lys Glu Asp Asn Gly Ile Gly Ile Leu Thr Leu Asn 
    50                  55                  60                  


Asn Pro Ser Arg Met Asn Ala Phe Ser Gly Val Met Met Leu Gln Leu 
65                  70                  75                  80  


Leu Glu Lys Val Ile Glu Leu Glu Asn Trp Thr Glu Gly Lys Gly Leu 
                85                  90                  95      


Ile Val Arg Gly Ala Lys Asn Thr Phe Ser Ser Gly Ser Asp Leu Asn 
            100                 105                 110         


Ala Val Lys Ser Leu Gly Thr Pro Glu Thr Ser Phe Asn Lys Cys Cys 
        115                 120                 125             


Ala Gly Ser Arg Leu Gly Ile Gly Trp Arg Ser Arg Ile Tyr Tyr Ser 
    130                 135                 140                 


Met 
145 


<210>  4459
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  4459

Met Val Val Phe Gly Tyr Glu Ala Gly Thr Lys Pro Arg Asp Ser Gly 
1               5                   10                  15      


Val Val Pro Val Gly Thr Glu Glu Ala Pro Lys Val Phe Lys Met Ala 
            20                  25                  30          


Ala Ser Met His Gly Gln Pro Ser Pro Ser Leu Glu Asp Ala Lys Leu 
        35                  40                  45              


Arg Arg Pro Met Val Ile Glu Ile Ile Glu Lys Asn Phe Asp Tyr Leu 
    50                  55                  60                  


Arg Lys Glu Met Thr Gln Asn Ile Tyr Gln Met Ala Thr Phe Gly Thr 
65                  70                  75                  80  


Thr Ala Gly Phe Ser Gly Ile Phe Ser Asn Phe Leu Phe Arg Arg Cys 
                85                  90                  95      


Phe Lys Val Lys His Asp Ala Leu Lys Thr Tyr Ala Ser Leu Ala Thr 
            100                 105                 110         


Leu Pro Phe Leu Ser Thr Val Val Thr Asp Lys Leu Phe Val Ile Asp 
        115                 120                 125             


Ala Leu Tyr Ser Asp Asn Ile Ser Lys Glu Asn Cys Val Phe Arg Ser 
    130                 135                 140                 


Ser Leu Ile Gly Ile Val Cys Gly Val Phe Tyr Pro Ser Ser Leu Ala 
145                 150                 155                 160 


Phe Thr Lys Asn Gly Arg Leu Ala Thr Lys Tyr His Thr Val Pro Leu 
                165                 170                 175     


Pro Pro Lys Gly Arg Val Leu Ile His Trp Met Thr Leu Cys Gln Thr 
            180                 185                 190         


Gln Met Lys Leu Met Ala Ile Pro Leu Val Phe Gln Ile Met Phe Gly 
        195                 200                 205             


Ile Leu Asn Gly Leu Tyr His Tyr Ala Val Phe Glu Glu Thr Leu Glu 
    210                 215                 220                 


Lys Thr Ile His Glu Glu 
225                 230 


<210>  4460
<211>  550
<212>  PRT
<213>  Homo sapiens

<400>  4460

Met Ala Phe Ser Lys Leu Leu Glu Gln Ala Gly Gly Val Gly Leu Phe 
1               5                   10                  15      


Gln Thr Leu Gln Val Leu Thr Phe Ile Leu Pro Cys Leu Met Ile Pro 
            20                  25                  30          


Ser Gln Met Leu Leu Glu Asn Phe Ser Ala Ala Ile Pro Gly His Arg 
        35                  40                  45              


Cys Trp Thr His Met Leu Asp Asn Gly Ser Ala Val Ser Thr Asn Met 
    50                  55                  60                  


Thr Pro Lys Ala Leu Leu Thr Ile Ser Ile Pro Pro Gly Pro Asn Gln 
65                  70                  75                  80  


Gly Pro His Gln Cys Arg Arg Phe Arg Gln Pro Gln Trp Gln Leu Leu 
                85                  90                  95      


Asp Pro Asn Ala Thr Ala Thr Ser Trp Ser Glu Ala Asp Thr Glu Pro 
            100                 105                 110         


Cys Val Asp Gly Trp Val Tyr Asp Arg Ser Val Phe Thr Ser Thr Ile 
        115                 120                 125             


Val Ala Lys Trp Asp Leu Val Cys Ser Ser Gln Gly Leu Lys Pro Leu 
    130                 135                 140                 


Ser Gln Ser Ile Phe Met Ser Gly Ile Leu Val Gly Ser Phe Ile Trp 
145                 150                 155                 160 


Gly Leu Leu Ser Tyr Arg Phe Gly Arg Lys Pro Met Leu Ser Trp Cys 
                165                 170                 175     


Cys Leu Gln Leu Ala Val Ala Gly Thr Ser Thr Ile Phe Ala Pro Thr 
            180                 185                 190         


Phe Val Ile Tyr Cys Gly Leu Arg Phe Val Ala Ala Phe Gly Met Ala 
        195                 200                 205             


Gly Ile Phe Leu Ser Ser Leu Thr Leu Met Val Glu Trp Thr Thr Thr 
    210                 215                 220                 


Ser Arg Arg Ala Val Thr Met Thr Val Val Gly Cys Ala Phe Ser Ala 
225                 230                 235                 240 


Gly Gln Ala Ala Leu Gly Gly Leu Ala Phe Ala Leu Arg Asp Trp Arg 
                245                 250                 255     


Thr Leu Gln Leu Ala Ala Ser Val Pro Phe Phe Ala Ile Ser Leu Ile 
            260                 265                 270         


Ser Trp Trp Leu Pro Glu Ser Ala Arg Trp Leu Ile Ile Lys Gly Lys 
        275                 280                 285             


Pro Asp Gln Ala Leu Gln Glu Leu Arg Lys Val Ala Arg Ile Asn Gly 
    290                 295                 300                 


His Lys Glu Ala Lys Asn Leu Thr Ile Glu Val Leu Met Ser Ser Val 
305                 310                 315                 320 


Lys Glu Glu Val Ala Ser Ala Lys Glu Pro Arg Ser Val Leu Asp Leu 
                325                 330                 335     


Phe Cys Val Pro Val Leu Arg Trp Arg Ser Cys Ala Met Leu Val Val 
            340                 345                 350         


Asn Phe Ser Leu Leu Ile Ser Tyr Tyr Gly Leu Val Phe Asp Leu Gln 
        355                 360                 365             


Ser Leu Gly Arg Asp Ile Phe Leu Leu Gln Ala Leu Phe Gly Ala Val 
    370                 375                 380                 


Asp Phe Leu Gly Arg Ala Thr Thr Ala Leu Leu Leu Ser Phe Leu Gly 
385                 390                 395                 400 


Arg Arg Thr Ile Gln Ala Gly Ser Gln Ala Met Ala Gly Leu Ala Ile 
                405                 410                 415     


Leu Ala Asn Met Leu Val Pro Gln Asp Leu Gln Thr Leu Arg Val Val 
            420                 425                 430         


Phe Ala Val Leu Gly Lys Gly Cys Phe Gly Ile Ser Leu Thr Cys Leu 
        435                 440                 445             


Thr Ile Tyr Lys Ala Glu Leu Phe Pro Thr Pro Val Arg Met Thr Ala 
    450                 455                 460                 


Asp Gly Ile Leu His Thr Val Gly Arg Leu Gly Ala Met Met Gly Pro 
465                 470                 475                 480 


Leu Ile Leu Met Ser Arg Gln Ala Leu Pro Leu Leu Pro Pro Leu Leu 
                485                 490                 495     


Tyr Gly Val Ile Ser Ile Ala Ser Ser Leu Val Val Leu Phe Phe Leu 
            500                 505                 510         


Pro Glu Thr Gln Gly Leu Pro Leu Pro Asp Thr Ile Gln Asp Leu Glu 
        515                 520                 525             


Ser Gln Lys Ser Thr Ala Ala Gln Gly Asn Arg Gln Glu Ala Val Thr 
    530                 535                 540                 


Val Glu Ser Thr Ser Leu 
545                 550 


<210>  4461
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  4461

Met Gly Asn Asp Ser Val Ser Tyr Glu Tyr Gly Asp Tyr Ser Asp Leu 
1               5                   10                  15      


Ser Asp Arg Pro Val Asp Cys Leu Asp Gly Ala Cys Leu Ala Ile Asp 
            20                  25                  30          


Pro Leu Arg Val Ala Pro Leu Pro Leu Tyr Ala Ala Ile Phe Leu Val 
        35                  40                  45              


Gly Val Pro Gly Asn Ala Met Val Ala Trp Val Ala Gly Lys Val Ala 
    50                  55                  60                  


Arg Arg Arg Val Gly Ala Thr Trp Leu Leu His Leu Ala Val Ala Asp 
65                  70                  75                  80  


Leu Leu Cys Cys Leu Ser Leu Pro Ile Leu Ala Val Pro Ile Ala Arg 
                85                  90                  95      


Gly Gly His Trp Pro Tyr Gly Ala Val Gly Cys Arg Ala Leu Pro Ser 
            100                 105                 110         


Ile Ile Leu Leu Thr Met Tyr Ala Ser Val Leu Leu Leu Ala Ala Leu 
        115                 120                 125             


Ser Ala Asp Leu Cys Phe Leu Ala Leu Gly Pro Ala Trp Trp Ser Thr 
    130                 135                 140                 


Val Gln Arg Ala Cys Gly Val Gln Val Ala Cys Gly Ala Ala Trp Thr 
145                 150                 155                 160 


Leu Ala Leu Leu Leu Thr Val Pro Ser Ala Ile Tyr Arg Arg Leu His 
                165                 170                 175     


Gln Glu His Phe Pro Ala Arg Leu Gln Cys Val Val Asp Tyr Gly Gly 
            180                 185                 190         


Ser Ser Ser Thr Glu Asn Ala Val Thr Ala Ile Arg Phe Leu Phe Gly 
        195                 200                 205             


Phe Leu Gly Pro Leu Val Ala Val Ala Ser Cys His Ser Ala Leu Leu 
    210                 215                 220                 


Cys Trp Ala Ala Arg Arg Cys Arg Pro Leu Gly Thr Ala Ile Val Val 
225                 230                 235                 240 


Gly Phe Phe Val Cys Trp Ala Pro Tyr His Leu Leu Gly Leu Val Leu 
                245                 250                 255     


Thr Val Ala Ala Pro Asn Ser Ala Leu Leu Ala Arg Ala Leu Arg Ala 
            260                 265                 270         


Glu Pro Leu Ile Val Gly Leu Ala Leu Ala His Ser Cys Leu Asn Pro 
        275                 280                 285             


Met Leu Phe Leu Tyr Phe Gly Arg Ala Gln Leu Arg Arg Ser Leu Pro 
    290                 295                 300                 


Ala Ala Cys His Trp Ala Leu Arg Glu Ser Gln Gly Gln Asp Glu Ser 
305                 310                 315                 320 


Val Asp Ser Lys Lys Ser Thr Ser His Asp Leu Val Ser Glu Met Glu 
                325                 330                 335     


Val 
    


<210>  4462
<211>  951
<212>  PRT
<213>  Homo sapiens

<400>  4462

Met Pro Gly Pro Leu Gly Leu Leu Cys Phe Leu Ala Leu Gly Leu Leu 
1               5                   10                  15      


Gly Ser Ala Gly Pro Ser Gly Ala Ala Pro Pro Leu Cys Ala Ala Pro 
            20                  25                  30          


Cys Ser Cys Asp Gly Asp Arg Arg Val Asp Cys Ser Gly Lys Gly Leu 
        35                  40                  45              


Thr Ala Val Pro Glu Gly Leu Ser Ala Phe Thr Gln Ala Leu Asp Ile 
    50                  55                  60                  


Ser Met Asn Asn Ile Thr Gln Leu Pro Glu Asp Ala Phe Lys Asn Phe 
65                  70                  75                  80  


Pro Phe Leu Glu Glu Leu Gln Leu Ala Gly Asn Asp Leu Ser Phe Ile 
                85                  90                  95      


His Pro Lys Ala Leu Ser Gly Leu Lys Glu Leu Lys Val Leu Thr Leu 
            100                 105                 110         


Gln Asn Asn Gln Leu Lys Thr Val Pro Ser Glu Ala Ile Arg Gly Leu 
        115                 120                 125             


Ser Ala Leu Gln Ser Leu Arg Leu Asp Ala Asn His Ile Thr Ser Val 
    130                 135                 140                 


Pro Glu Asp Ser Phe Glu Gly Leu Val Gln Leu Arg His Leu Trp Leu 
145                 150                 155                 160 


Asp Asp Asn Ser Leu Thr Glu Val Pro Val His Pro Leu Ser Asn Leu 
                165                 170                 175     


Pro Thr Leu Gln Ala Leu Thr Leu Ala Leu Asn Lys Ile Ser Ser Ile 
            180                 185                 190         


Pro Asp Phe Ala Phe Thr Asn Leu Ser Ser Leu Val Val Leu His Leu 
        195                 200                 205             


His Asn Asn Lys Ile Arg Ser Leu Ser Gln His Cys Phe Asp Gly Leu 
    210                 215                 220                 


Asp Asn Leu Glu Thr Leu Asp Leu Asn Tyr Asn Asn Leu Gly Glu Phe 
225                 230                 235                 240 


Pro Gln Ala Ile Lys Ala Leu Pro Ser Leu Lys Glu Leu Gly Phe His 
                245                 250                 255     


Ser Asn Ser Ile Ser Val Ile Pro Asp Gly Ala Phe Asp Gly Asn Pro 
            260                 265                 270         


Leu Leu Arg Thr Ile His Leu Tyr Asp Asn Pro Leu Ser Phe Val Gly 
        275                 280                 285             


Asn Ser Ala Phe His Asn Leu Ser Asp Leu His Ser Leu Val Ile Arg 
    290                 295                 300                 


Gly Ala Ser Met Val Gln Gln Phe Pro Asn Leu Thr Gly Thr Val His 
305                 310                 315                 320 


Leu Glu Ser Leu Thr Leu Thr Gly Thr Lys Ile Ser Ser Ile Pro Asn 
                325                 330                 335     


Asn Leu Cys Gln Glu Gln Lys Met Leu Arg Thr Leu Asp Leu Ser Tyr 
            340                 345                 350         


Asn Asn Ile Arg Asp Leu Pro Ser Phe Asn Gly Cys His Ala Leu Glu 
        355                 360                 365             


Glu Ile Ser Leu Gln Arg Asn Gln Ile Tyr Gln Ile Lys Glu Gly Thr 
    370                 375                 380                 


Phe Gln Gly Leu Ile Ser Leu Arg Ile Leu Asp Leu Ser Arg Asn Leu 
385                 390                 395                 400 


Ile His Glu Ile His Ser Arg Ala Phe Ala Thr Leu Gly Pro Ile Thr 
                405                 410                 415     


Asn Leu Asp Val Ser Phe Asn Glu Leu Thr Ser Phe Pro Thr Glu Gly 
            420                 425                 430         


Leu Asn Gly Leu Asn Gln Leu Lys Leu Val Gly Asn Phe Lys Leu Lys 
        435                 440                 445             


Glu Ala Leu Ala Ala Lys Asp Phe Val Asn Leu Arg Ser Leu Ser Val 
    450                 455                 460                 


Pro Tyr Ala Tyr Gln Cys Cys Ala Phe Trp Gly Cys Asp Ser Tyr Ala 
465                 470                 475                 480 


Asn Leu Asn Thr Glu Asp Asn Ser Leu Gln Asp His Ser Val Ala Gln 
                485                 490                 495     


Glu Lys Gly Thr Ala Asp Ala Ala Asn Val Thr Ser Thr Leu Glu Asn 
            500                 505                 510         


Glu Glu His Ser Gln Ile Ile Ile His Cys Thr Pro Ser Thr Gly Ala 
        515                 520                 525             


Phe Lys Pro Cys Glu Tyr Leu Leu Gly Ser Trp Met Ile Arg Leu Thr 
    530                 535                 540                 


Val Trp Phe Ile Phe Leu Val Ala Leu Phe Phe Asn Leu Leu Val Ile 
545                 550                 555                 560 


Leu Thr Thr Phe Ala Ser Cys Thr Ser Leu Pro Ser Ser Lys Leu Phe 
                565                 570                 575     


Ile Gly Leu Ile Ser Val Ser Asn Leu Phe Met Gly Ile Tyr Thr Gly 
            580                 585                 590         


Ile Leu Thr Phe Leu Asp Ala Val Ser Trp Gly Arg Phe Ala Glu Phe 
        595                 600                 605             


Gly Ile Trp Trp Glu Thr Gly Ser Gly Cys Lys Val Ala Gly Phe Leu 
    610                 615                 620                 


Ala Val Phe Ser Ser Glu Ser Ala Ile Phe Leu Leu Met Leu Ala Thr 
625                 630                 635                 640 


Val Glu Arg Ser Leu Ser Ala Lys Asp Ile Met Lys Asn Gly Lys Ser 
                645                 650                 655     


Asn His Leu Lys Gln Phe Arg Val Ala Ala Leu Leu Ala Phe Leu Gly 
            660                 665                 670         


Ala Thr Val Ala Gly Cys Phe Pro Leu Phe His Arg Gly Glu Tyr Ser 
        675                 680                 685             


Ala Ser Pro Leu Cys Leu Pro Phe Pro Thr Gly Glu Thr Pro Ser Leu 
    690                 695                 700                 


Gly Phe Thr Val Thr Leu Val Leu Leu Asn Ser Leu Ala Phe Leu Leu 
705                 710                 715                 720 


Met Ala Val Ile Tyr Thr Lys Leu Tyr Cys Asn Leu Glu Lys Glu Asp 
                725                 730                 735     


Leu Ser Glu Asn Ser Gln Ser Ser Met Ile Lys His Val Ala Trp Leu 
            740                 745                 750         


Ile Phe Thr Asn Cys Ile Phe Phe Cys Pro Val Ala Phe Phe Ser Phe 
        755                 760                 765             


Ala Pro Leu Ile Thr Ala Ile Ser Ile Ser Pro Glu Ile Met Lys Ser 
    770                 775                 780                 


Val Thr Leu Ile Phe Phe Pro Leu Pro Ala Cys Leu Asn Pro Val Leu 
785                 790                 795                 800 


Tyr Val Phe Phe Asn Pro Lys Phe Lys Glu Asp Trp Lys Leu Leu Lys 
                805                 810                 815     


Arg Arg Val Thr Lys Lys Ser Gly Ser Val Ser Val Ser Ile Ser Ser 
            820                 825                 830         


Gln Gly Gly Cys Leu Glu Gln Asp Phe Tyr Tyr Asp Cys Gly Met Tyr 
        835                 840                 845             


Ser His Leu Gln Gly Asn Leu Thr Val Cys Asp Cys Cys Glu Ser Phe 
    850                 855                 860                 


Leu Leu Thr Lys Pro Val Ser Cys Lys His Leu Ile Lys Ser His Ser 
865                 870                 875                 880 


Cys Pro Ala Leu Ala Val Ala Ser Cys Gln Arg Pro Glu Gly Tyr Trp 
                885                 890                 895     


Ser Asp Cys Gly Thr Gln Ser Ala His Ser Asp Tyr Ala Asp Glu Glu 
            900                 905                 910         


Asp Ser Phe Val Ser Asp Ser Ser Asp Gln Val Gln Ala Cys Gly Arg 
        915                 920                 925             


Ala Cys Phe Tyr Gln Ser Arg Gly Phe Pro Leu Val Arg Tyr Ala Tyr 
    930                 935                 940                 


Asn Leu Pro Arg Val Lys Asp 
945                 950     


<210>  4463
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  4463

Met Thr Lys Ala Gly Ser Lys Gly Gly Asn Leu Arg Asp Lys Leu Asp 
1               5                   10                  15      


Gly Asn Glu Leu Asp Leu Ser Leu Ser Asp Leu Asn Glu Val Pro Val 
            20                  25                  30          


Lys Glu Leu Ala Ala Leu Pro Lys Ala Thr Ile Leu Asp Leu Ser Cys 
        35                  40                  45              


Asn Lys Leu Thr Thr Leu Pro Ser Asp Phe Cys Gly Leu Thr His Leu 
    50                  55                  60                  


Val Lys Leu Asp Leu Ser Lys Asn Lys Leu Gln Gln Leu Pro Ala Asp 
65                  70                  75                  80  


Phe Gly Arg Leu Val Asn Leu Gln His Leu Asp Leu Leu Asn Asn Lys 
                85                  90                  95      


Leu Val Thr Leu Pro Val Ser Phe Ala Gln Leu Lys Asn Leu Lys Trp 
            100                 105                 110         


Leu Asp Leu Lys Asp Asn Pro Leu Asp Pro Val Leu Ala Lys Val Ala 
        115                 120                 125             


Gly Asp Cys Leu Asp Glu Lys Gln Cys Lys Gln Cys Ala Asn Lys Val 
    130                 135                 140                 


Leu Gln His Met Lys Ala Val Gln Ala Asp Gln Glu Arg Glu Arg Gln 
145                 150                 155                 160 


Arg Arg Leu Glu Val Glu Arg Glu Ala Glu Lys Lys Arg Glu Ala Lys 
                165                 170                 175     


Gln Arg Ala Lys Glu Ala Gln Glu Arg Glu Leu Arg Lys Arg Glu Lys 
            180                 185                 190         


Ala Glu Glu Lys Glu Arg Arg Arg Lys Glu Tyr Asp Ala Leu Lys Ala 
        195                 200                 205             


Ala Lys Arg Glu Gln Glu Lys Lys Pro Lys Lys Glu Ala Asn Gln Ala 
    210                 215                 220                 


Pro Lys Ser Lys Ser Gly Ser Arg Pro Arg Lys Pro Pro Pro Arg Lys 
225                 230                 235                 240 


His Thr Arg Ser Trp Ala Val Leu Lys Leu Leu Leu Leu Leu Leu Leu 
                245                 250                 255     


Phe Gly Val Ala Gly Gly Leu Val Ala Cys Arg Val Thr Glu Leu Gln 
            260                 265                 270         


Gln Gln Pro Leu Cys Thr Ser Val Asn Thr Ile Tyr Asp Asn Ala Val 
        275                 280                 285             


Gln Gly Leu Arg Arg His Glu Ile Leu Gln Trp Val Leu Gln Thr Asp 
    290                 295                 300                 


Ser Gln Gln 
305         


<210>  4464
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  4464

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Gly Glu Asn Phe Lys Gly Gly Thr 
                805                 810                 815     


Leu Leu Pro Gly Thr Glu Pro Thr Val Asp Thr Val Pro Met Gln Pro 
            820                 825                 830         


Ile Pro Ala Tyr Trp Tyr Tyr Val Met Ala Ala Gly Gly Ala Val Leu 
        835                 840                 845             


Val Leu Val Ser Val Ala Leu Ala Leu Val Leu His Tyr His Arg Phe 
    850                 855                 860                 


Arg Tyr Ala Ala Lys Lys Thr Asp His Ser Ile Thr Tyr Lys Thr Ser 
865                 870                 875                 880 


His Tyr Thr Asn Gly Ala Pro Leu Ala Val Glu Pro Thr Leu Thr Ile 
                885                 890                 895     


Lys Leu Glu Gln Asp Arg Gly Ser His Cys 
            900                 905     


<210>  4465
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  4465

Met Glu Met Ala Ser Ser Ala Gly Ser Trp Leu Ser Gly Cys Leu Ile 
1               5                   10                  15      


Pro Leu Val Phe Leu Arg Leu Ser Val His Val Ser Gly His Ala Gly 
            20                  25                  30          


Asp Ala Gly Lys Phe His Val Ala Leu Leu Gly Gly Thr Ala Glu Leu 
        35                  40                  45              


Leu Cys Pro Leu Ser Leu Trp Pro Gly Thr Val Pro Lys Glu Val Arg 
    50                  55                  60                  


Trp Leu Arg Ser Pro Phe Pro Gln Arg Ser Gln Ala Val His Ile Phe 
65                  70                  75                  80  


Arg Asp Gly Lys Asp Gln Asp Glu Asp Leu Met Pro Glu Tyr Lys Gly 
                85                  90                  95      


Arg Thr Val Leu Val Arg Asp Ala Gln Glu Gly Ser Val Thr Leu Gln 
            100                 105                 110         


Ile Leu Asp Val Arg Leu Glu Asp Gln Gly Ser Tyr Arg Cys Leu Ile 
        115                 120                 125             


Gln Val Gly Asn Leu Ser Lys Glu Asp Thr Val Ile Leu Gln Val Ala 
    130                 135                 140                 


Ala Pro Ser Val Gly Ser Leu Ser Pro Ser Ala Val Ala Leu Ala Val 
145                 150                 155                 160 


Ile Leu Pro Val Leu Val Leu Leu Ile Met Val Cys Leu Cys Leu Ile 
                165                 170                 175     


Trp Lys Gln Arg Arg Ala Lys Glu Lys Leu Leu Tyr Glu His Val Thr 
            180                 185                 190         


Glu Val Asp Asn Leu Leu Ser Asp His Ala Lys Glu Lys Gly Lys Leu 
        195                 200                 205             


His Lys Ala Val Lys Lys Leu Arg Ser Glu Leu Lys Leu Lys Arg Ala 
    210                 215                 220                 


Ala Ala Asn Ser Gly Trp Arg Arg Ala Arg Leu His Phe Val Ala Val 
225                 230                 235                 240 


Thr Leu Asp Pro Asp Thr Ala His Pro Lys Leu Ile Leu Ser Glu Asp 
                245                 250                 255     


Gln Arg Cys Val Arg Leu Gly Asp Arg Arg Gln Pro Val Pro Asp Asn 
            260                 265                 270         


Pro Gln Arg Phe Asp Phe Val Val Ser Ile Leu Gly Ser Glu Tyr Phe 
        275                 280                 285             


Thr Thr Gly Cys His Tyr Trp Glu Val Tyr Val Gly Asp Lys Thr Lys 
    290                 295                 300                 


Trp Ile Leu Gly Val Cys Ser Glu Ser Val Ser Arg Lys Gly Lys Val 
305                 310                 315                 320 


Thr Ala Ser Pro Ala Asn Gly His Trp Leu Leu Arg Gln Ser Arg Gly 
                325                 330                 335     


Asn Glu Tyr Glu Ala Leu Thr Ser Pro Gln Thr Ser Phe Arg Leu Lys 
            340                 345                 350         


Glu Pro Pro Arg Cys Val Gly Ile Phe Leu Asp Tyr Glu Ala Gly Val 
        355                 360                 365             


Ile Ser Phe Tyr Asn Val Thr Asn Lys Ser His Ile Phe Thr Phe Thr 
    370                 375                 380                 


His Asn Phe Ser Gly Pro Leu Arg Pro Phe Phe Glu Pro Cys Leu His 
385                 390                 395                 400 


Asp Gly Gly Lys Asn Thr Ala Pro Leu Val Ile Cys Ser Glu Leu His 
                405                 410                 415     


Lys Ser Glu Glu Ser Ile Val Pro Arg Pro Glu Gly Lys Gly His Ala 
            420                 425                 430         


Asn Gly Asp Val Ser Leu Lys Val Asn Ser Ser Leu Leu Pro Pro Lys 
        435                 440                 445             


Ala Pro Glu Leu Lys Asp Ile Ile Leu Ser Leu Pro Pro Asp Leu Gly 
    450                 455                 460                 


Pro Ala Leu Gln Glu Leu Lys Ala Pro Ser Phe 
465                 470                 475 


<210>  4466
<211>  387
<212>  PRT
<213>  Homo sapiens

<400>  4466

Met Pro Val Pro Ala Ser Trp Pro His Pro Pro Gly Pro Phe Leu Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Gly Leu Thr Glu Val Ala Gly Glu Glu Glu Leu 
            20                  25                  30          


Gln Met Ile Gln Pro Glu Lys Leu Leu Leu Val Thr Val Gly Lys Thr 
        35                  40                  45              


Ala Thr Leu His Cys Thr Val Thr Ser Leu Leu Pro Val Gly Pro Val 
    50                  55                  60                  


Leu Trp Phe Arg Gly Val Gly Pro Gly Arg Glu Leu Ile Tyr Asn Gln 
65                  70                  75                  80  


Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu Thr Lys 
                85                  90                  95      


Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Ser Ser Ile Thr Pro Ala 
            100                 105                 110         


Asp Val Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser Pro Glu 
        115                 120                 125             


Asn Val Glu Phe Lys Ser Gly Pro Gly Thr Glu Met Ala Leu Gly Ala 
    130                 135                 140                 


Lys Pro Ser Ala Pro Val Val Leu Gly Pro Ala Ala Arg Thr Thr Pro 
145                 150                 155                 160 


Glu His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro Arg 
                165                 170                 175     


Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp Phe 
            180                 185                 190         


Gln Thr Asn Val Asp Pro Thr Gly Gln Ser Val Ala Tyr Ser Ile Arg 
        195                 200                 205             


Ser Thr Ala Arg Val Val Leu Asp Pro Trp Asp Val Arg Ser Gln Val 
    210                 215                 220                 


Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg Gly 
225                 230                 235                 240 


Thr Ala Asn Leu Ser Glu Ala Ile Arg Val Pro Pro Thr Leu Glu Val 
                245                 250                 255     


Thr Gln Gln Pro Met Arg Val Gly Asn Gln Val Asn Val Thr Cys Gln 
            260                 265                 270         


Val Arg Lys Phe Tyr Pro Gln Ser Leu Gln Leu Thr Trp Ser Glu Asn 
        275                 280                 285             


Gly Asn Val Cys Gln Arg Glu Thr Ala Ser Thr Leu Thr Glu Asn Lys 
    290                 295                 300                 


Asp Gly Thr Tyr Asn Trp Thr Ser Trp Phe Leu Val Asn Ile Ser Asp 
305                 310                 315                 320 


Gln Arg Asp Asp Val Val Leu Thr Cys Gln Val Lys His Asp Gly Gln 
                325                 330                 335     


Leu Ala Val Ser Lys Arg Leu Ala Leu Glu Val Thr Val His Gln Lys 
            340                 345                 350         


Asp Gln Ser Ser Asp Ala Thr Pro Gly Pro Ala Ser Ser Leu Thr Ala 
        355                 360                 365             


Leu Leu Leu Ile Ala Val Leu Leu Gly Pro Ile Tyr Val Pro Trp Lys 
    370                 375                 380                 


Gln Lys Thr 
385         


<210>  4467
<211>  4599
<212>  PRT
<213>  Homo sapiens

<400>  4467

Met Ser Glu Phe Leu Leu Ala Leu Leu Thr Leu Ser Gly Leu Leu Pro 
1               5                   10                  15      


Ile Ala Arg Val Leu Thr Val Gly Ala Asp Arg Asp Gln Gln Leu Cys 
            20                  25                  30          


Asp Pro Gly Glu Phe Leu Cys His Asp His Val Thr Cys Val Ser Gln 
        35                  40                  45              


Ser Trp Leu Cys Asp Gly Asp Pro Asp Cys Pro Asp Asp Ser Asp Glu 
    50                  55                  60                  


Ser Leu Asp Thr Cys Pro Glu Glu Val Glu Ile Lys Cys Pro Leu Asn 
65                  70                  75                  80  


His Ile Ala Cys Leu Gly Thr Asn Lys Cys Val His Leu Ser Gln Leu 
                85                  90                  95      


Cys Asn Gly Val Leu Asp Cys Pro Asp Gly Tyr Asp Glu Gly Val His 
            100                 105                 110         


Cys Gln Glu Leu Leu Ser Asn Cys Gln Gln Leu Asn Cys Gln Tyr Lys 
        115                 120                 125             


Cys Thr Met Val Arg Asn Ser Thr Arg Cys Tyr Cys Glu Asp Gly Phe 
    130                 135                 140                 


Glu Ile Thr Glu Asp Gly Arg Ser Cys Lys Asp Gln Asp Glu Cys Ala 
145                 150                 155                 160 


Val Tyr Gly Thr Cys Ser Gln Thr Cys Arg Asn Thr His Gly Ser Tyr 
                165                 170                 175     


Thr Cys Ser Cys Val Glu Gly Tyr Leu Met Gln Pro Asp Asn Arg Ser 
            180                 185                 190         


Cys Lys Ala Lys Ile Glu Pro Thr Asp Arg Pro Pro Ile Leu Leu Ile 
        195                 200                 205             


Ala Asn Phe Glu Thr Ile Glu Val Phe Tyr Leu Asn Gly Ser Lys Met 
    210                 215                 220                 


Ala Thr Leu Ser Ser Val Asn Gly Asn Glu Ile His Thr Leu Asp Phe 
225                 230                 235                 240 


Ile Tyr Asn Glu Asp Met Ile Cys Trp Ile Glu Ser Arg Glu Ser Ser 
                245                 250                 255     


Asn Gln Leu Lys Cys Ile Gln Ile Thr Lys Ala Gly Gly Leu Thr Asp 
            260                 265                 270         


Glu Trp Thr Ile Asn Ile Leu Gln Ser Phe His Asn Val Gln Gln Met 
        275                 280                 285             


Ala Ile Asp Trp Leu Thr Arg Asn Leu Tyr Phe Val Asp His Val Gly 
    290                 295                 300                 


Asp Arg Ile Phe Val Cys Asn Ser Asn Gly Ser Val Cys Val Thr Leu 
305                 310                 315                 320 


Ile Asp Leu Glu Leu His Asn Pro Lys Ala Ile Ala Val Asp Pro Ile 
                325                 330                 335     


Ala Gly Lys Leu Phe Phe Thr Asp Tyr Gly Asn Val Ala Lys Val Glu 
            340                 345                 350         


Arg Cys Asp Met Asp Gly Met Asn Arg Thr Arg Ile Ile Asp Ser Lys 
        355                 360                 365             


Thr Glu Gln Pro Ala Ala Leu Ala Leu Asp Leu Val Asn Lys Leu Val 
    370                 375                 380                 


Tyr Trp Val Asp Leu Tyr Leu Asp Tyr Val Gly Val Val Asp Tyr Gln 
385                 390                 395                 400 


Gly Lys Asn Arg His Thr Val Ile Gln Gly Arg Gln Val Arg His Leu 
                405                 410                 415     


Tyr Gly Ile Thr Val Phe Glu Asp Tyr Leu Tyr Ala Thr Asn Ser Asp 
            420                 425                 430         


Asn Tyr Asn Ile Val Arg Ile Asn Arg Phe Asn Gly Thr Asp Ile His 
        435                 440                 445             


Ser Leu Ile Lys Ile Glu Asn Ala Trp Gly Ile Arg Ile Tyr Gln Lys 
    450                 455                 460                 


Arg Thr Gln Pro Thr Val Arg Ser His Ala Cys Glu Val Asp Pro Tyr 
465                 470                 475                 480 


Gly Met Pro Gly Gly Cys Ser His Ile Cys Leu Leu Ser Ser Ser Tyr 
                485                 490                 495     


Lys Thr Arg Thr Cys Arg Cys Arg Thr Gly Phe Asn Leu Gly Ser Asp 
            500                 505                 510         


Gly Arg Ser Cys Lys Arg Pro Lys Asn Glu Leu Phe Leu Phe Tyr Gly 
        515                 520                 525             


Lys Gly Arg Pro Gly Ile Val Arg Gly Met Asp Leu Asn Thr Lys Ile 
    530                 535                 540                 


Ala Asp Glu Tyr Met Ile Pro Ile Glu Asn Leu Val Asn Pro Arg Ala 
545                 550                 555                 560 


Leu Asp Phe His Ala Glu Thr Asn Tyr Ile Tyr Phe Ala Asp Thr Thr 
                565                 570                 575     


Ser Phe Leu Ile Gly Arg Gln Lys Ile Asp Gly Thr Glu Arg Glu Thr 
            580                 585                 590         


Ile Leu Lys Asp Asp Leu Asp Asn Val Glu Gly Ile Ala Val Asp Trp 
        595                 600                 605             


Ile Gly Asn Asn Leu Tyr Trp Thr Asn Asp Gly His Arg Lys Thr Ile 
    610                 615                 620                 


Asn Val Ala Arg Leu Glu Lys Ala Ser Gln Ser Arg Lys Thr Leu Leu 
625                 630                 635                 640 


Glu Gly Glu Met Ser His Pro Arg Gly Ile Val Val Asp Pro Val Asn 
                645                 650                 655     


Gly Trp Met Tyr Trp Thr Asp Trp Glu Glu Asp Glu Ile Asp Asp Ser 
            660                 665                 670         


Val Gly Arg Ile Glu Lys Ala Trp Met Asp Gly Phe Asn Arg Gln Ile 
        675                 680                 685             


Phe Val Thr Ser Lys Met Leu Trp Pro Asn Gly Leu Thr Leu Asp Phe 
    690                 695                 700                 


His Thr Asn Thr Leu Tyr Trp Cys Asp Ala Tyr Tyr Asp His Ile Glu 
705                 710                 715                 720 


Lys Val Phe Leu Asn Gly Thr His Arg Lys Ile Val Tyr Ser Gly Arg 
                725                 730                 735     


Glu Leu Asn His Pro Phe Gly Leu Ser His His Gly Asn Tyr Val Phe 
            740                 745                 750         


Trp Thr Asp Tyr Met Asn Gly Ser Ile Phe Gln Leu Asp Leu Ile Thr 
        755                 760                 765             


Ser Glu Val Thr Leu Leu Arg His Glu Arg Pro Pro Leu Phe Gly Leu 
    770                 775                 780                 


Gln Ile Tyr Asp Pro Arg Lys Gln Gln Gly Asp Asn Met Cys Arg Val 
785                 790                 795                 800 


Asn Asn Gly Gly Cys Ser Thr Leu Cys Leu Ala Ile Pro Gly Gly Arg 
                805                 810                 815     


Val Cys Ala Cys Ala Asp Asn Gln Leu Leu Asp Glu Asn Gly Thr Thr 
            820                 825                 830         


Cys Thr Phe Asn Pro Gly Glu Ala Leu Pro His Ile Cys Lys Ala Gly 
        835                 840                 845             


Glu Phe Arg Cys Lys Asn Arg His Cys Ile Gln Ala Arg Trp Lys Cys 
    850                 855                 860                 


Asp Gly Asp Asp Asp Cys Leu Asp Gly Ser Asp Glu Asp Ser Val Asn 
865                 870                 875                 880 


Cys Phe Asn His Ser Cys Pro Asp Asp Gln Phe Lys Cys Gln Asn Asn 
                885                 890                 895     


Arg Cys Ile Pro Lys Arg Trp Leu Cys Asp Gly Ala Asn Asp Cys Gly 
            900                 905                 910         


Ser Asn Glu Asp Glu Ser Asn Gln Thr Cys Thr Ala Arg Thr Cys Gln 
        915                 920                 925             


Val Asp Gln Phe Ser Cys Gly Asn Gly Arg Cys Ile Pro Arg Ala Trp 
    930                 935                 940                 


Leu Cys Asp Arg Glu Asp Asp Cys Gly Asp Gln Thr Asp Glu Met Ala 
945                 950                 955                 960 


Ser Cys Glu Phe Pro Thr Cys Glu Pro Leu Thr Gln Phe Val Cys Lys 
                965                 970                 975     


Ser Gly Arg Cys Ile Ser Ser Lys Trp His Cys Asp Ser Asp Asp Asp 
            980                 985                 990         


Cys Gly Asp Gly Ser Asp Glu Val  Gly Cys Val His Ser  Cys Phe Asp 
        995                 1000                 1005             


Asn Gln  Phe Arg Cys Ser Ser  Gly Arg Cys Ile Pro  Gly His Trp 
    1010                 1015                 1020             


Ala Cys  Asp Gly Asp Asn Asp  Cys Gly Asp Phe Ser  Asp Glu Ala 
    1025                 1030                 1035             


Gln Ile  Asn Cys Thr Lys Glu  Glu Ile His Ser Pro  Ala Gly Cys 
    1040                 1045                 1050             


Asn Gly  Asn Glu Phe Gln Cys  His Pro Asp Gly Asn  Cys Val Pro 
    1055                 1060                 1065             


Asp Leu  Trp Arg Cys Asp Gly  Glu Lys Asp Cys Glu  Asp Gly Ser 
    1070                 1075                 1080             


Asp Glu  Lys Gly Cys Asn Gly  Thr Ile Arg Leu Cys  Asp His Lys 
    1085                 1090                 1095             


Thr Lys  Phe Ser Cys Trp Ser  Thr Gly Arg Cys Ile  Asn Lys Ala 
    1100                 1105                 1110             


Trp Val  Cys Asp Gly Asp Ile  Asp Cys Glu Asp Gln  Ser Asp Glu 
    1115                 1120                 1125             


Asp Asp  Cys Asp Ser Phe Leu  Cys Gly Pro Pro Lys  His Pro Cys 
    1130                 1135                 1140             


Ala Asn  Asp Thr Ser Val Cys  Leu Gln Pro Glu Lys  Leu Cys Asn 
    1145                 1150                 1155             


Gly Lys  Lys Asp Cys Pro Asp  Gly Ser Asp Glu Gly  Tyr Leu Cys 
    1160                 1165                 1170             


Asp Glu  Cys Ser Leu Asn Asn  Gly Gly Cys Ser Asn  His Cys Ser 
    1175                 1180                 1185             


Val Val  Pro Gly Arg Gly Ile  Val Cys Ser Cys Pro  Glu Gly Leu 
    1190                 1195                 1200             


Gln Leu  Asn Lys Asp Asn Lys  Thr Cys Glu Ile Val  Asp Tyr Cys 
    1205                 1210                 1215             


Ser Asn  His Leu Lys Cys Ser  Gln Val Cys Glu Gln  His Lys His 
    1220                 1225                 1230             


Thr Val  Lys Cys Ser Cys Tyr  Glu Gly Trp Lys Leu  Asp Val Asp 
    1235                 1240                 1245             


Gly Glu  Ser Cys Thr Ser Val  Asp Pro Phe Glu Ala  Phe Ile Ile 
    1250                 1255                 1260             


Phe Ser  Ile Arg His Glu Ile  Arg Arg Ile Asp Leu  His Lys Arg 
    1265                 1270                 1275             


Asp Tyr  Ser Leu Leu Val Pro  Gly Leu Arg Asn Thr  Ile Ala Leu 
    1280                 1285                 1290             


Asp Phe  His Phe Asn Gln Ser  Leu Leu Tyr Trp Thr  Asp Val Val 
    1295                 1300                 1305             


Glu Asp  Arg Ile Tyr Arg Gly  Lys Leu Ser Glu Ser  Gly Gly Val 
    1310                 1315                 1320             


Ser Ala  Ile Glu Val Val Val  Glu His Gly Leu Ala  Thr Pro Glu 
    1325                 1330                 1335             


Gly Leu  Thr Val Asp Trp Ile  Ala Gly Asn Ile Tyr  Trp Ile Asp 
    1340                 1345                 1350             


Ser Asn  Leu Asp Gln Ile Glu  Val Ala Lys Leu Asp  Gly Ser Leu 
    1355                 1360                 1365             


Arg Thr  Thr Leu Ile Ala Gly  Ala Met Glu His Pro  Arg Ala Ile 
    1370                 1375                 1380             


Ala Leu  Asp Pro Arg Tyr Gly  Ile Leu Phe Trp Thr  Asp Trp Asp 
    1385                 1390                 1395             


Ala Asn  Phe Pro Arg Ile Glu  Ser Ala Ser Met Ser  Gly Ala Gly 
    1400                 1405                 1410             


Arg Lys  Thr Ile Tyr Lys Asp  Met Lys Thr Gly Ala  Trp Pro Asn 
    1415                 1420                 1425             


Gly Leu  Thr Val Asp His Phe  Glu Lys Arg Ile Val  Trp Thr Asp 
    1430                 1435                 1440             


Ala Arg  Ser Asp Ala Ile Tyr  Ser Ala Leu Tyr Asp  Gly Thr Asn 
    1445                 1450                 1455             


Met Ile  Glu Ile Ile Arg Gly  His Glu Tyr Leu Ser  His Pro Phe 
    1460                 1465                 1470             


Ala Val  Ser Leu Tyr Gly Ser  Glu Val Tyr Trp Thr  Asp Trp Arg 
    1475                 1480                 1485             


Thr Asn  Thr Leu Ser Lys Ala  Asn Lys Trp Thr Gly  Gln Asn Val 
    1490                 1495                 1500             


Ser Val  Ile Gln Lys Thr Ser  Ala Gln Pro Phe Asp  Leu Gln Ile 
    1505                 1510                 1515             


Tyr His  Pro Ser Arg Gln Pro  Gln Ala Pro Asn Pro  Cys Ala Ala 
    1520                 1525                 1530             


Asn Asp  Gly Lys Gly Pro Cys  Ser His Met Cys Leu  Ile Asn His 
    1535                 1540                 1545             


Asn Arg  Ser Ala Ala Cys Ala  Cys Pro His Leu Met  Lys Leu Ser 
    1550                 1555                 1560             


Ser Asp  Lys Lys Thr Cys Tyr  Glu Met Lys Lys Phe  Leu Leu Tyr 
    1565                 1570                 1575             


Ala Arg  Arg Ser Glu Ile Arg  Gly Val Asp Ile Asp  Asn Pro Tyr 
    1580                 1585                 1590             


Phe Asn  Phe Ile Thr Ala Phe  Thr Val Pro Asp Ile  Asp Asp Val 
    1595                 1600                 1605             


Thr Val  Ile Asp Phe Asp Ala  Ser Glu Glu Arg Leu  Tyr Trp Thr 
    1610                 1615                 1620             


Asp Ile  Lys Thr Gln Thr Ile  Lys Arg Ala Phe Ile  Asn Gly Thr 
    1625                 1630                 1635             


Gly Leu  Glu Thr Val Ile Ser  Arg Asp Ile Gln Ser  Ile Arg Gly 
    1640                 1645                 1650             


Leu Ala  Val Asp Trp Val Ser  Arg Asn Leu Tyr Trp  Ile Ser Ser 
    1655                 1660                 1665             


Glu Phe  Asp Glu Thr Gln Ile  Asn Val Ala Arg Leu  Asp Gly Ser 
    1670                 1675                 1680             


Leu Lys  Thr Ser Ile Ile His  Gly Ile Asp Lys Pro  Gln Cys Leu 
    1685                 1690                 1695             


Ala Ala  His Pro Val Arg Gly  Lys Leu Tyr Trp Thr  Asp Gly Asn 
    1700                 1705                 1710             


Thr Ile  Asn Met Ala Asn Met  Asp Gly Ser Asn Ser  Lys Ile Leu 
    1715                 1720                 1725             


Phe Gln  Asn Gln Lys Glu Pro  Val Gly Leu Ser Ile  Asp Tyr Val 
    1730                 1735                 1740             


Glu Asn  Lys Leu Tyr Trp Ile  Ser Ser Gly Asn Gly  Thr Ile Asn 
    1745                 1750                 1755             


Arg Cys  Asn Leu Asp Gly Gly  Asn Leu Glu Val Ile  Glu Ser Met 
    1760                 1765                 1770             


Lys Glu  Glu Leu Thr Lys Ala  Thr Ala Leu Thr Ile  Met Asp Lys 
    1775                 1780                 1785             


Lys Leu  Trp Trp Ala Asp Gln  Asn Leu Ala Gln Leu  Gly Thr Cys 
    1790                 1795                 1800             


Ser Lys  Arg Asp Gly Arg Asn  Pro Thr Ile Leu Arg  Asn Lys Thr 
    1805                 1810                 1815             


Ser Gly  Val Val His Met Lys  Val Tyr Asp Lys Glu  Ala Gln Gln 
    1820                 1825                 1830             


Gly Ser  Asn Ser Cys Gln Leu  Asn Asn Gly Gly Cys  Ser Gln Leu 
    1835                 1840                 1845             


Cys Leu  Pro Thr Ser Glu Thr  Thr Arg Thr Cys Met  Cys Thr Val 
    1850                 1855                 1860             


Gly Tyr  Tyr Leu Gln Lys Asn  Arg Met Ser Cys Gln  Gly Ile Glu 
    1865                 1870                 1875             


Ser Phe  Leu Met Tyr Ser Val  His Glu Gly Ile Arg  Gly Ile Pro 
    1880                 1885                 1890             


Leu Glu  Pro Ser Asp Lys Met  Asp Ala Leu Met Pro  Ile Ser Gly 
    1895                 1900                 1905             


Thr Ser  Phe Ala Val Gly Ile  Asp Phe His Ala Glu  Asn Asp Thr 
    1910                 1915                 1920             


Ile Tyr  Trp Thr Asp Met Gly  Phe Asn Lys Ile Ser  Arg Ala Lys 
    1925                 1930                 1935             


Arg Asp  Gln Thr Trp Lys Glu  Asp Ile Ile Thr Asn  Gly Leu Gly 
    1940                 1945                 1950             


Arg Val  Glu Gly Ile Ala Val  Asp Trp Ile Ala Gly  Asn Ile Tyr 
    1955                 1960                 1965             


Trp Thr  Asp His Gly Phe Asn  Leu Ile Glu Val Ala  Arg Leu Asn 
    1970                 1975                 1980             


Gly Ser  Phe Arg Tyr Val Ile  Ile Ser Gln Gly Leu  Asp Gln Pro 
    1985                 1990                 1995             


Arg Ser  Ile Ala Val His Pro  Glu Lys Gly Leu Leu  Phe Trp Thr 
    2000                 2005                 2010             


Glu Trp  Gly Gln Met Pro Cys  Ile Gly Lys Ala Arg  Leu Asp Gly 
    2015                 2020                 2025             


Ser Glu  Lys Val Val Leu Val  Ser Met Gly Ile Ala  Trp Pro Asn 
    2030                 2035                 2040             


Gly Ile  Ser Ile Asp Tyr Glu  Glu Asn Lys Leu Tyr  Trp Cys Asp 
    2045                 2050                 2055             


Ala Arg  Thr Asp Lys Ile Glu  Arg Ile Asp Leu Glu  Thr Gly Gly 
    2060                 2065                 2070             


Asn Arg  Glu Met Val Leu Ser  Gly Ser Asn Val Asp  Met Phe Ser 
    2075                 2080                 2085             


Val Ala  Val Phe Gly Ala Tyr  Ile Tyr Trp Ser Asp  Arg Ala His 
    2090                 2095                 2100             


Ala Asn  Gly Ser Val Arg Arg  Gly His Lys Asn Asp  Ala Thr Glu 
    2105                 2110                 2115             


Thr Ile  Thr Met Arg Thr Gly  Leu Gly Val Asn Leu  Lys Glu Val 
    2120                 2125                 2130             


Lys Ile  Phe Asn Arg Val Arg  Glu Lys Gly Thr Asn  Val Cys Ala 
    2135                 2140                 2145             


Arg Asp  Asn Gly Gly Cys Lys  Gln Leu Cys Leu Tyr  Arg Gly Asn 
    2150                 2155                 2160             


Ser Arg  Arg Thr Cys Ala Cys  Ala His Gly Tyr Leu  Ala Glu Asp 
    2165                 2170                 2175             


Gly Val  Thr Cys Leu Arg His  Glu Gly Tyr Leu Leu  Tyr Ser Gly 
    2180                 2185                 2190             


Arg Thr  Ile Leu Lys Ser Ile  His Leu Ser Asp Glu  Thr Asn Leu 
    2195                 2200                 2205             


Asn Ser  Pro Ile Arg Pro Tyr  Glu Asn Pro Arg Tyr  Phe Lys Asn 
    2210                 2215                 2220             


Val Ile  Ala Leu Ala Phe Asp  Tyr Asn Gln Arg Arg  Lys Gly Thr 
    2225                 2230                 2235             


Asn Arg  Ile Phe Tyr Ser Asp  Ala His Phe Gly Asn  Ile Gln Leu 
    2240                 2245                 2250             


Ile Lys  Asp Asn Trp Glu Asp  Arg Gln Val Ile Val  Glu Asn Val 
    2255                 2260                 2265             


Gly Ser  Val Glu Gly Leu Ala  Tyr His Arg Ala Trp  Asp Thr Leu 
    2270                 2275                 2280             


Tyr Trp  Thr Ser Ser Thr Thr  Ser Ser Ile Thr Arg  His Thr Val 
    2285                 2290                 2295             


Asp Gln  Thr Arg Pro Gly Ala  Phe Asp Arg Glu Ala  Val Ile Thr 
    2300                 2305                 2310             


Met Ser  Glu Asp Asp His Pro  His Val Leu Ala Leu  Asp Glu Cys 
    2315                 2320                 2325             


Gln Asn  Leu Met Phe Trp Thr  Asn Trp Asn Glu Gln  His Pro Ser 
    2330                 2335                 2340             


Ile Met  Arg Ser Thr Leu Thr  Gly Lys Asn Ala Gln  Val Val Val 
    2345                 2350                 2355             


Ser Thr  Asp Ile Leu Thr Pro  Asn Gly Leu Thr Ile  Asp Tyr Arg 
    2360                 2365                 2370             


Ala Glu  Lys Leu Tyr Phe Ser  Asp Gly Ser Leu Gly  Lys Ile Glu 
    2375                 2380                 2385             


Arg Cys  Glu Tyr Asp Gly Ser  Gln Arg His Val Ile  Val Lys Ser 
    2390                 2395                 2400             


Gly Pro  Gly Thr Phe Leu Ser  Leu Ala Val Tyr Asp  Asn Tyr Ile 
    2405                 2410                 2415             


Phe Trp  Ser Asp Trp Gly Arg  Arg Ala Ile Leu Arg  Ser Asn Lys 
    2420                 2425                 2430             


Tyr Thr  Gly Gly Asp Thr Lys  Ile Leu Arg Ser Asp  Ile Pro His 
    2435                 2440                 2445             


Gln Pro  Met Gly Ile Ile Ala  Val Ala Asn Asp Thr  Asn Ser Cys 
    2450                 2455                 2460             


Glu Leu  Ser Pro Cys Ala Leu  Leu Asn Gly Gly Cys  His Asp Leu 
    2465                 2470                 2475             


Cys Leu  Leu Thr Pro Asn Gly  Arg Val Asn Cys Ser  Cys Arg Gly 
    2480                 2485                 2490             


Asp Arg  Ile Leu Leu Glu Asp  Asn Arg Cys Val Thr  Lys Asn Ser 
    2495                 2500                 2505             


Ser Cys  Asn Ala Tyr Ser Glu  Phe Glu Cys Gly Asn  Gly Glu Cys 
    2510                 2515                 2520             


Ile Asp  Tyr Gln Leu Thr Cys  Asp Gly Ile Pro His  Cys Lys Asp 
    2525                 2530                 2535             


Lys Ser  Asp Glu Lys Leu Leu  Tyr Cys Glu Asn Arg  Ser Cys Arg 
    2540                 2545                 2550             


Arg Gly  Phe Lys Pro Cys Tyr  Asn Arg Arg Cys Ile  Pro His Gly 
    2555                 2560                 2565             


Lys Leu  Cys Asp Gly Glu Asn  Asp Cys Gly Asp Asn  Ser Asp Glu 
    2570                 2575                 2580             


Leu Asp  Cys Lys Val Ser Thr  Cys Ala Thr Val Glu  Phe Arg Cys 
    2585                 2590                 2595             


Ala Asp  Gly Thr Cys Ile Pro  Arg Ser Ala Arg Cys  Asn Gln Asn 
    2600                 2605                 2610             


Ile Asp  Cys Ala Asp Ala Ser  Asp Glu Lys Asn Cys  Asn Asn Thr 
    2615                 2620                 2625             


Asp Cys  Thr His Phe Tyr Lys  Leu Gly Val Lys Thr  Thr Gly Phe 
    2630                 2635                 2640             


Ile Arg  Cys Asn Ser Thr Ser  Leu Cys Val Leu Pro  Thr Trp Ile 
    2645                 2650                 2655             


Cys Asp  Gly Ser Asn Asp Cys  Gly Asp Tyr Ser Asp  Glu Leu Lys 
    2660                 2665                 2670             


Cys Pro  Val Gln Asn Lys His  Lys Cys Glu Glu Asn  Tyr Phe Ser 
    2675                 2680                 2685             


Cys Pro  Ser Gly Arg Cys Ile  Leu Asn Thr Trp Ile  Cys Asp Gly 
    2690                 2695                 2700             


Gln Lys  Asp Cys Glu Asp Gly  Arg Asp Glu Phe His  Cys Asp Ser 
    2705                 2710                 2715             


Ser Cys  Ser Trp Asn Gln Phe  Ala Cys Ser Ala Gln  Lys Cys Ile 
    2720                 2725                 2730             


Ser Lys  His Trp Ile Cys Asp  Gly Glu Asp Asp Cys  Gly Asp Gly 
    2735                 2740                 2745             


Leu Asp  Glu Ser Asp Ser Ile  Cys Gly Ala Ile Thr  Cys Ala Ala 
    2750                 2755                 2760             


Asp Met  Phe Ser Cys Gln Gly  Ser Arg Ala Cys Val  Pro Arg His 
    2765                 2770                 2775             


Trp Leu  Cys Asp Gly Glu Arg  Asp Cys Pro Asp Gly  Ser Asp Glu 
    2780                 2785                 2790             


Leu Ser  Thr Ala Gly Cys Ala  Pro Asn Asn Thr Cys  Asp Glu Asn 
    2795                 2800                 2805             


Ala Phe  Met Cys His Asn Lys  Val Cys Ile Pro Lys  Gln Phe Val 
    2810                 2815                 2820             


Cys Asp  His Asp Asp Asp Cys  Gly Asp Gly Ser Asp  Glu Ser Pro 
    2825                 2830                 2835             


Gln Cys  Gly Tyr Arg Gln Cys  Gly Thr Glu Glu Phe  Ser Cys Ala 
    2840                 2845                 2850             


Asp Gly  Arg Cys Leu Leu Asn  Thr Gln Trp Gln Cys  Asp Gly Asp 
    2855                 2860                 2865             


Phe Asp  Cys Pro Asp His Ser  Asp Glu Ala Pro Leu  Asn Pro Lys 
    2870                 2875                 2880             


Cys Lys  Ser Ala Glu Gln Ser  Cys Asn Ser Ser Phe  Phe Met Cys 
    2885                 2890                 2895             


Lys Asn  Gly Arg Cys Ile Pro  Ser Gly Gly Leu Cys  Asp Asn Lys 
    2900                 2905                 2910             


Asp Asp  Cys Gly Asp Gly Ser  Asp Glu Arg Asn Cys  His Ile Asn 
    2915                 2920                 2925             


Glu Cys  Leu Ser Lys Lys Val  Ser Gly Cys Ser Gln  Asp Cys Gln 
    2930                 2935                 2940             


Asp Leu  Pro Val Ser Tyr Lys  Cys Lys Cys Trp Pro  Gly Phe Gln 
    2945                 2950                 2955             


Leu Lys  Asp Asp Gly Lys Thr  Cys Val Asp Ile Asp  Glu Cys Ser 
    2960                 2965                 2970             


Ser Gly  Phe Pro Cys Ser Gln  Gln Cys Ile Asn Thr  Tyr Gly Thr 
    2975                 2980                 2985             


Tyr Lys  Cys Leu Cys Thr Asp  Gly Tyr Glu Ile Gln  Pro Asp Asn 
    2990                 2995                 3000             


Pro Asn  Gly Cys Lys Ser Leu  Ser Asp Glu Glu Pro  Phe Leu Ile 
    3005                 3010                 3015             


Leu Ala  Asp His His Glu Ile  Arg Lys Ile Ser Thr  Asp Gly Ser 
    3020                 3025                 3030             


Asn Tyr  Thr Leu Leu Lys Gln  Gly Leu Asn Asn Val  Ile Ala Ile 
    3035                 3040                 3045             


Asp Phe  Asp Tyr Arg Glu Glu  Phe Ile Tyr Trp Ile  Asp Ser Ser 
    3050                 3055                 3060             


Arg Pro  Asn Gly Ser Arg Ile  Asn Arg Met Cys Leu  Asn Gly Ser 
    3065                 3070                 3075             


Asp Ile  Lys Val Val His Asn  Thr Ala Val Pro Asn  Ala Leu Ala 
    3080                 3085                 3090             


Val Asp  Trp Ile Gly Lys Asn  Leu Tyr Trp Ser Asp  Thr Glu Lys 
    3095                 3100                 3105             


Arg Ile  Ile Glu Val Ser Lys  Leu Asn Gly Leu Tyr  Pro Thr Ile 
    3110                 3115                 3120             


Leu Val  Ser Lys Arg Leu Lys  Phe Pro Arg Asp Leu  Ser Leu Asp 
    3125                 3130                 3135             


Pro Gln  Ala Gly Tyr Leu Tyr  Trp Ile Asp Cys Cys  Glu Tyr Pro 
    3140                 3145                 3150             


His Ile  Gly Arg Val Gly Met  Asp Gly Thr Asn Gln  Ser Val Val 
    3155                 3160                 3165             


Ile Glu  Thr Lys Ile Ser Arg  Pro Met Ala Leu Thr  Ile Asp Tyr 
    3170                 3175                 3180             


Val Asn  Arg Arg Leu Tyr Trp  Ala Asp Glu Asn His  Ile Glu Phe 
    3185                 3190                 3195             


Ser Asn  Met Asp Gly Ser His  Arg His Lys Val Pro  Asn Gln Asp 
    3200                 3205                 3210             


Ile Pro  Gly Val Ile Ala Leu  Thr Leu Phe Glu Asp  Tyr Ile Tyr 
    3215                 3220                 3225             


Trp Thr  Asp Gly Lys Thr Lys  Ser Leu Ser Arg Ala  His Lys Thr 
    3230                 3235                 3240             


Ser Gly  Ala Asp Arg Leu Ser  Leu Ile Tyr Ser Trp  His Ala Ile 
    3245                 3250                 3255             


Thr Asp  Ile Gln Val Tyr His  Ser Tyr Arg Gln Pro  Asp Val Ser 
    3260                 3265                 3270             


Lys His  Leu Cys Met Ile Asn  Asn Gly Gly Cys Ser  His Leu Cys 
    3275                 3280                 3285             


Leu Leu  Ala Pro Gly Lys Thr  His Thr Cys Ala Cys  Pro Thr Asn 
    3290                 3295                 3300             


Phe Tyr  Leu Ala Ala Asp Asn  Arg Thr Cys Leu Ser  Asn Cys Thr 
    3305                 3310                 3315             


Ala Ser  Gln Phe Arg Cys Lys  Thr Asp Lys Cys Ile  Pro Phe Trp 
    3320                 3325                 3330             


Trp Lys  Cys Asp Thr Val Asp  Asp Cys Gly Asp Gly  Ser Asp Glu 
    3335                 3340                 3345             


Pro Asp  Asp Cys Pro Glu Phe  Arg Cys Gln Pro Gly  Arg Phe Gln 
    3350                 3355                 3360             


Cys Gly  Thr Gly Leu Cys Ala  Leu Pro Ala Phe Ile  Cys Asp Gly 
    3365                 3370                 3375             


Glu Asn  Asp Cys Gly Asp Asn  Ser Asp Glu Leu Asn  Cys Asp Thr 
    3380                 3385                 3390             


His Val  Cys Leu Ser Gly Gln  Phe Lys Cys Thr Lys  Asn Gln Lys 
    3395                 3400                 3405             


Cys Ile  Pro Val Asn Leu Arg  Cys Asn Gly Gln Asp  Asp Cys Gly 
    3410                 3415                 3420             


Asp Glu  Glu Asp Glu Arg Asp  Cys Pro Glu Asn Ser  Cys Ser Pro 
    3425                 3430                 3435             


Asp Tyr  Phe Gln Cys Lys Thr  Thr Lys His Cys Ile  Ser Lys Leu 
    3440                 3445                 3450             


Trp Val  Cys Asp Glu Asp Pro  Asp Cys Ala Asp Ala  Ser Asp Glu 
    3455                 3460                 3465             


Ala Asn  Cys Asp Lys Lys Thr  Cys Gly Pro His Glu  Phe Gln Cys 
    3470                 3475                 3480             


Lys Asn  Asn Asn Cys Ile Pro  Asp His Trp Arg Cys  Asp Ser Gln 
    3485                 3490                 3495             


Asn Asp  Cys Ser Asp Asn Ser  Asp Glu Glu Asn Cys  Lys Pro Gln 
    3500                 3505                 3510             


Thr Cys  Thr Leu Lys Asp Phe  Leu Cys Ala Asn Gly  Asp Cys Val 
    3515                 3520                 3525             


Ser Ser  Arg Phe Trp Cys Asp  Gly Asp Phe Asp Cys  Ala Asp Gly 
    3530                 3535                 3540             


Ser Asp  Glu Arg Asn Cys Glu  Thr Ser Cys Ser Lys  Asp Gln Phe 
    3545                 3550                 3555             


Arg Cys  Ser Asn Gly Gln Cys  Ile Pro Ala Lys Trp  Lys Cys Asp 
    3560                 3565                 3570             


Gly His  Glu Asp Cys Lys Tyr  Gly Glu Asp Glu Lys  Ser Cys Glu 
    3575                 3580                 3585             


Pro Ala  Ser Pro Thr Cys Ser  Ser Arg Glu Tyr Ile  Cys Ala Ser 
    3590                 3595                 3600             


Asp Gly  Cys Ile Ser Ala Ser  Leu Lys Cys Asn Gly  Glu Tyr Asp 
    3605                 3610                 3615             


Cys Ala  Asp Gly Ser Asp Glu  Met Asp Cys Val Thr  Glu Cys Lys 
    3620                 3625                 3630             


Glu Asp  Gln Phe Arg Cys Lys  Asn Lys Ala His Cys  Ile Pro Ile 
    3635                 3640                 3645             


Arg Trp  Leu Cys Asp Gly Ile  His Asp Cys Val Asp  Gly Ser Asp 
    3650                 3655                 3660             


Glu Glu  Asn Cys Glu Arg Gly  Gly Asn Ile Cys Arg  Ala Asp Glu 
    3665                 3670                 3675             


Phe Leu  Cys Asn Asn Ser Leu  Cys Lys Leu His Phe  Trp Val Cys 
    3680                 3685                 3690             


Asp Gly  Glu Asp Asp Cys Gly  Asp Asn Ser Asp Glu  Ala Pro Asp 
    3695                 3700                 3705             


Met Cys  Val Lys Phe Leu Cys  Pro Ser Thr Arg Pro  His Arg Cys 
    3710                 3715                 3720             


Arg Asn  Asn Arg Ile Cys Leu  Gln Ser Glu Gln Met  Cys Asn Gly 
    3725                 3730                 3735             


Ile Asp  Glu Cys Gly Asp Asn  Ser Asp Glu Asp His  Cys Gly Gly 
    3740                 3745                 3750             


Lys Leu  Thr Tyr Lys Ala Arg  Pro Cys Lys Lys Asp  Glu Phe Ala 
    3755                 3760                 3765             


Cys Ser  Asn Lys Lys Cys Ile  Pro Met Asp Leu Gln  Cys Asp Arg 
    3770                 3775                 3780             


Leu Asp  Asp Cys Gly Asp Gly  Ser Asp Glu Gln Gly  Cys Arg Ile 
    3785                 3790                 3795             


Ala Pro  Thr Glu Tyr Thr Cys  Glu Asp Asn Val Asn  Pro Cys Gly 
    3800                 3805                 3810             


Asp Asp  Ala Tyr Cys Asn Gln  Ile Lys Thr Ser Val  Phe Cys Arg 
    3815                 3820                 3825             


Cys Lys  Pro Gly Phe Gln Arg  Asn Met Lys Asn Arg  Gln Cys Glu 
    3830                 3835                 3840             


Asp Leu  Asn Glu Cys Leu Val  Phe Gly Thr Cys Ser  His Gln Cys 
    3845                 3850                 3855             


Ile Asn  Val Glu Gly Ser Tyr  Lys Cys Val Cys Asp  Gln Asn Phe 
    3860                 3865                 3870             


Gln Glu  Arg Asn Asn Thr Cys  Ile Ala Glu Gly Ser  Glu Asp Gln 
    3875                 3880                 3885             


Val Leu  Tyr Ile Ala Asn Asp  Thr Asp Ile Leu Gly  Phe Ile Tyr 
    3890                 3895                 3900             


Pro Phe  Asn Tyr Ser Gly Asp  His Gln Gln Ile Ser  His Ile Glu 
    3905                 3910                 3915             


His Asn  Ser Arg Ile Thr Gly  Met Asp Val Tyr Tyr  Gln Arg Asp 
    3920                 3925                 3930             


Met Ile  Ile Trp Ser Thr Gln  Phe Asn Pro Gly Gly  Ile Phe Tyr 
    3935                 3940                 3945             


Lys Arg  Ile His Gly Arg Glu  Lys Arg Gln Ala Asn  Ser Gly Leu 
    3950                 3955                 3960             


Ile Cys  Pro Glu Phe Lys Arg  Pro Arg Asp Ile Ala  Val Asp Trp 
    3965                 3970                 3975             


Val Ala  Gly Asn Ile Tyr Trp  Thr Asp His Ser Arg  Met His Trp 
    3980                 3985                 3990             


Phe Ser  Tyr Tyr Thr Thr His  Trp Thr Ser Leu Arg  Tyr Ser Ile 
    3995                 4000                 4005             


Asn Val  Gly Gln Leu Asn Gly  Pro Asn Cys Thr Arg  Leu Leu Thr 
    4010                 4015                 4020             


Asn Met  Ala Gly Glu Pro Tyr  Ala Ile Ala Val Asn  Pro Lys Arg 
    4025                 4030                 4035             


Gly Met  Met Tyr Trp Thr Val  Val Gly Asp His Ser  His Ile Glu 
    4040                 4045                 4050             


Glu Ala  Ala Met Asp Gly Thr  Leu Arg Arg Ile Leu  Val Gln Lys 
    4055                 4060                 4065             


Asn Leu  Gln Arg Pro Thr Gly  Leu Ala Val Asp Tyr  Phe Ser Glu 
    4070                 4075                 4080             


Arg Ile  Tyr Trp Ala Asp Phe  Glu Leu Ser Ile Ile  Gly Ser Val 
    4085                 4090                 4095             


Leu Tyr  Asp Gly Ser Asn Ser  Val Val Ser Val Ser  Ser Lys Gln 
    4100                 4105                 4110             


Gly Leu  Leu His Pro His Arg  Ile Asp Ile Phe Glu  Asp Tyr Ile 
    4115                 4120                 4125             


Tyr Gly  Ala Gly Pro Lys Asn  Gly Val Phe Arg Val  Gln Lys Phe 
    4130                 4135                 4140             


Gly His  Gly Ser Val Glu Tyr  Leu Ala Leu Asn Ile  Asp Lys Thr 
    4145                 4150                 4155             


Lys Gly  Val Leu Ile Ser His  Arg Tyr Lys Gln Leu  Asp Leu Pro 
    4160                 4165                 4170             


Asn Pro  Cys Leu Asp Leu Ala  Cys Glu Phe Leu Cys  Leu Leu Asn 
    4175                 4180                 4185             


Pro Ser  Gly Ala Thr Cys Val  Cys Pro Glu Gly Lys  Tyr Leu Ile 
    4190                 4195                 4200             


Asn Gly  Thr Cys Asn Asp Asp  Ser Leu Leu Asp Asp  Ser Cys Lys 
    4205                 4210                 4215             


Leu Thr  Cys Glu Asn Gly Gly  Arg Cys Ile Leu Asn  Glu Lys Gly 
    4220                 4225                 4230             


Asp Leu  Arg Cys His Cys Trp  Pro Ser Tyr Ser Gly  Glu Arg Cys 
    4235                 4240                 4245             


Glu Val  Asn His Cys Ser Asn  Tyr Cys Gln Asn Gly  Gly Thr Cys 
    4250                 4255                 4260             


Val Pro  Ser Val Leu Gly Arg  Pro Thr Cys Ser Cys  Ala Leu Gly 
    4265                 4270                 4275             


Phe Thr  Gly Pro Asn Cys Gly  Lys Thr Val Cys Glu  Asp Phe Cys 
    4280                 4285                 4290             


Gln Asn  Gly Gly Thr Cys Ile  Val Thr Ala Gly Asn  Gln Pro Tyr 
    4295                 4300                 4305             


Cys His  Cys Gln Pro Glu Tyr  Thr Gly Asp Arg Cys  Gln Tyr Tyr 
    4310                 4315                 4320             


Val Cys  His His Tyr Cys Val  Asn Ser Glu Ser Cys  Thr Ile Gly 
    4325                 4330                 4335             


Asp Asp  Gly Ser Val Glu Cys  Val Cys Pro Thr Arg  Tyr Glu Gly 
    4340                 4345                 4350             


Pro Lys  Cys Glu Val Asp Lys  Cys Val Arg Cys His  Gly Gly His 
    4355                 4360                 4365             


Cys Ile  Ile Asn Lys Asp Ser  Glu Asp Ile Phe Cys  Asn Cys Thr 
    4370                 4375                 4380             


Asn Gly  Lys Ile Ala Ser Ser  Cys Gln Leu Cys Asp  Gly Tyr Cys 
    4385                 4390                 4395             


Tyr Asn  Gly Gly Thr Cys Gln  Leu Asp Pro Glu Thr  Asn Val Pro 
    4400                 4405                 4410             


Val Cys  Leu Cys Ser Thr Asn  Trp Ser Gly Thr Gln  Cys Glu Arg 
    4415                 4420                 4425             


Pro Ala  Pro Lys Ser Ser Lys  Ser Asp His Ile Ser  Thr Arg Ser 
    4430                 4435                 4440             


Ile Ala  Ile Ile Val Pro Leu  Val Leu Leu Val Thr  Leu Ile Thr 
    4445                 4450                 4455             


Thr Leu  Val Ile Gly Leu Val  Leu Cys Lys Arg Lys  Arg Arg Thr 
    4460                 4465                 4470             


Lys Thr  Ile Arg Arg Gln Pro  Ile Ile Asn Gly Gly  Ile Asn Val 
    4475                 4480                 4485             


Glu Ile  Gly Asn Pro Ser Tyr  Asn Met Tyr Glu Val  Asp His Asp 
    4490                 4495                 4500             


His Asn  Asp Gly Gly Leu Leu  Asp Pro Gly Phe Met  Ile Asp Pro 
    4505                 4510                 4515             


Thr Lys  Ala Arg Tyr Ile Gly  Gly Gly Pro Ser Ala  Phe Lys Leu 
    4520                 4525                 4530             


Pro His  Thr Ala Pro Pro Ile  Tyr Leu Asn Ser Asp  Leu Lys Gly 
    4535                 4540                 4545             


Pro Leu  Thr Ala Gly Pro Thr  Asn Tyr Ser Asn Pro  Val Tyr Ala 
    4550                 4555                 4560             


Lys Leu  Tyr Met Asp Gly Gln  Asn Cys Arg Asn Ser  Leu Gly Ser 
    4565                 4570                 4575             


Val Asp  Glu Arg Lys Glu Leu  Leu Pro Lys Lys Ile  Glu Ile Gly 
    4580                 4585                 4590             


Ile Arg  Glu Thr Val Ala 
    4595                 


<210>  4468
<211>  632
<212>  PRT
<213>  Homo sapiens

<400>  4468

Met Gly Ile Arg Gly Met Leu Arg Ala Ala Val Ile Leu Leu Leu Ile 
1               5                   10                  15      


Arg Thr Trp Leu Ala Glu Gly Asn Tyr Pro Ser Pro Ile Pro Lys Phe 
            20                  25                  30          


His Phe Glu Phe Ser Ser Ala Val Pro Glu Val Val Leu Asn Leu Phe 
        35                  40                  45              


Asn Cys Lys Asn Cys Ala Asn Glu Ala Val Val Gln Lys Ile Leu Asp 
    50                  55                  60                  


Arg Val Leu Ser Arg Tyr Asp Val Arg Leu Arg Pro Asn Phe Gly Gly 
65                  70                  75                  80  


Ala Pro Val Pro Val Arg Ile Ser Ile Tyr Val Thr Ser Ile Glu Gln 
                85                  90                  95      


Ile Ser Glu Met Asn Met Asp Tyr Thr Ile Thr Met Phe Phe His Gln 
            100                 105                 110         


Thr Trp Lys Asp Ser Arg Leu Ala Tyr Tyr Glu Thr Thr Leu Asn Leu 
        115                 120                 125             


Thr Leu Asp Tyr Arg Met His Glu Lys Leu Trp Val Pro Asp Cys Tyr 
    130                 135                 140                 


Phe Leu Asn Ser Lys Asp Ala Phe Val His Asp Val Thr Val Glu Asn 
145                 150                 155                 160 


Arg Val Phe Gln Leu His Pro Asp Gly Thr Val Arg Tyr Gly Ile Arg 
                165                 170                 175     


Leu Thr Thr Thr Ala Ala Cys Ser Leu Asp Leu His Lys Phe Pro Met 
            180                 185                 190         


Asp Lys Gln Ala Cys Asn Leu Val Val Glu Ser Tyr Gly Tyr Thr Val 
        195                 200                 205             


Glu Asp Ile Ile Leu Phe Trp Asp Asp Asn Gly Asn Ala Ile His Met 
    210                 215                 220                 


Thr Glu Glu Leu His Ile Pro Gln Phe Thr Phe Leu Gly Arg Thr Ile 
225                 230                 235                 240 


Thr Ser Lys Glu Val Tyr Phe Tyr Thr Gly Ser Tyr Ile Arg Leu Ile 
                245                 250                 255     


Leu Lys Phe Gln Val Gln Arg Glu Val Asn Ser Tyr Leu Val Gln Val 
            260                 265                 270         


Tyr Trp Pro Thr Val Leu Thr Thr Ile Thr Ser Trp Ile Ser Phe Trp 
        275                 280                 285             


Met Asn Tyr Asp Ser Ser Ala Ala Arg Val Thr Ile Gly Leu Thr Ser 
    290                 295                 300                 


Met Leu Ile Leu Thr Thr Ile Asp Ser His Leu Arg Asp Lys Leu Pro 
305                 310                 315                 320 


Asn Ile Ser Cys Ile Lys Ala Ile Asp Ile Tyr Ile Leu Val Cys Leu 
                325                 330                 335     


Phe Phe Val Phe Leu Ser Leu Leu Glu Tyr Val Tyr Ile Asn Tyr Leu 
            340                 345                 350         


Phe Tyr Ser Arg Gly Pro Arg Arg Gln Pro Arg Arg His Arg Arg Pro 
        355                 360                 365             


Arg Arg Val Ile Ala Arg Tyr Arg Tyr Gln Gln Val Val Val Gly Asn 
    370                 375                 380                 


Val Gln Asp Gly Leu Ile Asn Val Glu Asp Gly Val Ser Ser Leu Pro 
385                 390                 395                 400 


Ile Thr Pro Ala Gln Ala Pro Leu Ala Ser Pro Glu Ser Leu Gly Ser 
                405                 410                 415     


Leu Thr Ser Thr Ser Glu Gln Ala Gln Leu Ala Thr Ser Glu Ser Leu 
            420                 425                 430         


Ser Pro Leu Thr Ser Leu Ser Gly Gln Ala Pro Leu Ala Thr Gly Glu 
        435                 440                 445             


Ser Leu Ser Asp Leu Pro Ser Thr Ser Glu Gln Ala Arg His Ser Tyr 
    450                 455                 460                 


Gly Val Arg Phe Asn Gly Phe Gln Ala Asp Asp Ser Ile Ile Pro Thr 
465                 470                 475                 480 


Glu Ile Arg Asn Arg Val Glu Ala His Gly His Gly Val Thr His Asp 
                485                 490                 495     


His Glu Asp Ser Asn Glu Ser Leu Ser Ser Asp Glu Arg His Gly His 
            500                 505                 510         


Gly Pro Ser Gly Lys Pro Met Leu His His Gly Glu Lys Gly Val Gln 
        515                 520                 525             


Glu Ala Gly Trp Asp Leu Asp Asp Asn Asn Asp Lys Ser Asp Cys Leu 
    530                 535                 540                 


Ala Ile Lys Glu Gln Phe Lys Cys Asp Thr Asn Ser Thr Trp Gly Leu 
545                 550                 555                 560 


Asn Asp Asp Glu Leu Met Ala His Gly Gln Glu Lys Asp Ser Ser Ser 
                565                 570                 575     


Glu Ser Glu Asp Ser Cys Pro Pro Ser Pro Gly Cys Ser Phe Thr Glu 
            580                 585                 590         


Gly Phe Ser Phe Asp Leu Phe Asn Pro Asp Tyr Val Pro Lys Val Asp 
        595                 600                 605             


Lys Trp Ser Arg Phe Leu Phe Pro Leu Ala Phe Gly Leu Phe Asn Ile 
    610                 615                 620                 


Val Tyr Trp Val Tyr His Met Tyr 
625                 630         


<210>  4469
<211>  542
<212>  PRT
<213>  Homo sapiens

<400>  4469

Met Pro Arg Arg Gly Leu Ile Leu His Thr Arg Thr His Trp Leu Leu 
1               5                   10                  15      


Leu Gly Leu Ala Leu Leu Cys Ser Leu Val Leu Phe Met Tyr Leu Leu 
            20                  25                  30          


Glu Cys Ala Pro Gln Thr Asp Gly Asn Ala Ser Leu Pro Gly Val Val 
        35                  40                  45              


Gly Glu Asn Tyr Gly Lys Glu Tyr Tyr Gln Ala Leu Leu Gln Glu Gln 
    50                  55                  60                  


Glu Glu His Tyr Gln Thr Arg Ala Thr Ser Leu Lys Arg Gln Ile Ala 
65                  70                  75                  80  


Gln Leu Lys Gln Glu Leu Gln Glu Met Ser Glu Lys Met Arg Ser Leu 
                85                  90                  95      


Gln Glu Arg Arg Asn Val Gly Ala Asn Gly Ile Gly Tyr Gln Ser Asn 
            100                 105                 110         


Lys Glu Gln Ala Pro Ser Asp Leu Leu Glu Phe Leu His Ser Gln Ile 
        115                 120                 125             


Asp Lys Ala Glu Val Ser Ile Gly Ala Lys Leu Pro Ser Glu Tyr Gly 
    130                 135                 140                 


Val Ile Pro Phe Glu Ser Phe Thr Leu Met Lys Val Phe Gln Leu Glu 
145                 150                 155                 160 


Met Gly Leu Thr Arg His Pro Glu Glu Lys Pro Val Arg Lys Asp Lys 
                165                 170                 175     


Arg Asp Glu Leu Val Glu Val Ile Glu Ala Gly Leu Glu Val Ile Asn 
            180                 185                 190         


Asn Pro Asp Glu Asp Asp Glu Gln Glu Asp Glu Glu Gly Pro Leu Gly 
        195                 200                 205             


Glu Lys Leu Ile Phe Asn Glu Asn Asp Phe Val Glu Gly Tyr Tyr Arg 
    210                 215                 220                 


Thr Glu Arg Asp Lys Gly Thr Gln Tyr Glu Leu Phe Phe Lys Lys Ala 
225                 230                 235                 240 


Asp Leu Thr Glu Tyr Arg His Val Thr Leu Phe Arg Pro Phe Gly Pro 
                245                 250                 255     


Leu Met Lys Val Lys Ser Glu Met Ile Asp Ile Thr Arg Ser Ile Ile 
            260                 265                 270         


Asn Ile Ile Val Pro Leu Ala Glu Arg Thr Glu Ala Phe Val Gln Phe 
        275                 280                 285             


Met Gln Asn Phe Arg Asp Val Cys Ile His Gln Asp Lys Lys Ile His 
    290                 295                 300                 


Leu Thr Val Val Tyr Phe Gly Lys Glu Gly Leu Ser Lys Val Lys Ser 
305                 310                 315                 320 


Ile Leu Glu Ser Val Thr Ser Glu Ser Asn Phe His Asn Tyr Thr Leu 
                325                 330                 335     


Val Ser Leu Asn Glu Glu Phe Asn Arg Gly Arg Gly Leu Asn Val Gly 
            340                 345                 350         


Ala Arg Ala Trp Asp Lys Gly Glu Val Leu Met Phe Phe Cys Asp Val 
        355                 360                 365             


Asp Ile Tyr Phe Ser Ala Glu Phe Leu Asn Ser Cys Arg Leu Asn Ala 
    370                 375                 380                 


Glu Pro Gly Lys Lys Val Phe Tyr Pro Val Val Phe Ser Leu Tyr Asn 
385                 390                 395                 400 


Pro Ala Ile Val Tyr Ala Asn Gln Glu Val Pro Pro Pro Val Glu Gln 
                405                 410                 415     


Gln Leu Val His Lys Lys Asp Ser Gly Phe Trp Arg Asp Phe Gly Phe 
            420                 425                 430         


Gly Met Thr Cys Gln Tyr Arg Ser Asp Phe Leu Thr Ile Gly Gly Phe 
        435                 440                 445             


Asp Met Glu Val Lys Gly Trp Gly Gly Glu Asp Val His Leu Tyr Arg 
    450                 455                 460                 


Lys Tyr Leu His Gly Asp Leu Ile Val Ile Arg Thr Pro Val Pro Gly 
465                 470                 475                 480 


Leu Phe His Leu Trp His Glu Lys Arg Cys Ala Asp Glu Leu Thr Pro 
                485                 490                 495     


Glu Gln Tyr Arg Met Cys Ile Gln Ser Lys Ala Met Asn Glu Ala Ser 
            500                 505                 510         


His Ser His Leu Gly Met Leu Val Phe Arg Glu Glu Ile Glu Thr His 
        515                 520                 525             


Leu His Lys Gln Ala Tyr Arg Thr Asn Ser Glu Ala Val Gly 
    530                 535                 540         


<210>  4470
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  4470

Met Val Leu Ser Gln Glu Glu Pro Asp Ser Ala Arg Gly Thr Ser Glu 
1               5                   10                  15      


Ala Gln Pro Leu Gly Pro Ala Pro Thr Gly Ala Ala Pro Pro Pro Gly 
            20                  25                  30          


Pro Gly Pro Ser Asp Ser Pro Glu Ala Ala Val Glu Lys Val Glu Val 
        35                  40                  45              


Glu Leu Ala Gly Pro Ala Thr Ala Glu Pro His Glu Pro Pro Glu Pro 
    50                  55                  60                  


Pro Glu Gly Gly Trp Gly Trp Leu Val Met Leu Ala Ala Met Trp Cys 
65                  70                  75                  80  


Asn Gly Ser Val Phe Gly Ile Gln Asn Ala Cys Gly Val Leu Phe Val 
                85                  90                  95      


Ser Met Leu Glu Thr Phe Gly Ser Lys Asp Asp Asp Lys Met Val Phe 
            100                 105                 110         


Lys Thr Ala Trp Val Gly Ser Leu Ser Met Gly Met Ile Phe Phe Cys 
        115                 120                 125             


Cys Pro Ile Val Ser Val Phe Thr Asp Leu Phe Gly Cys Arg Lys Thr 
    130                 135                 140                 


Ala Val Val Gly Ala Ala Val Gly Phe Val Gly Leu Met Ser Ser Ser 
145                 150                 155                 160 


Phe Val Ser Ser Ile Glu Pro Leu Tyr Leu Thr Tyr Gly Ile Ile Phe 
                165                 170                 175     


Ala Cys Gly Cys Ser Phe Ala Tyr Gln Pro Ser Leu Val Ile Leu Gly 
            180                 185                 190         


His Tyr Phe Lys Lys Arg Leu Gly Leu Val Asn Gly Ile Val Thr Ala 
        195                 200                 205             


Gly Ser Ser Val Phe Thr Ile Leu Leu Pro Leu Leu Leu Arg Val Leu 
    210                 215                 220                 


Ile Asp Ser Val Gly Leu Phe Tyr Thr Leu Arg Val Leu Cys Ile Phe 
225                 230                 235                 240 


Met Phe Val Leu Phe Leu Ala Gly Phe Thr Tyr Arg Pro Leu Ala Thr 
                245                 250                 255     


Ser Thr Lys Asp Lys Glu Ser Gly Gly Ser Gly Ser Ser Leu Phe Ser 
            260                 265                 270         


Arg Lys Lys Phe Ser Pro Pro Lys Lys Ile Phe Asn Phe Ala Ile Phe 
        275                 280                 285             


Lys Val Thr Ala Tyr Ala Val Trp Ala Val Gly Ile Pro Leu Ala Leu 
    290                 295                 300                 


Phe Gly Tyr Phe Val Pro Tyr Val His Leu Met Lys His Val Asn Glu 
305                 310                 315                 320 


Arg Phe Gln Asp Glu Lys Asn Lys Glu Val Val Leu Met Cys Ile Gly 
                325                 330                 335     


Val Thr Ser Gly Val Gly Arg Leu Leu Phe Gly Arg Ile Ala Asp Tyr 
            340                 345                 350         


Val Pro Gly Val Lys Lys Val Tyr Leu Gln Val Leu Ser Phe Phe Phe 
        355                 360                 365             


Ile Gly Leu Met Ser Met Met Ile Pro Leu Cys Ser Ile Phe Gly Ala 
    370                 375                 380                 


Leu Ile Ala Val Cys Leu Ile Met Gly Leu Phe Asp Gly Cys Phe Ile 
385                 390                 395                 400 


Ser Ile Met Ala Pro Ile Ala Phe Glu Leu Val Gly Ala Gln Asp Val 
                405                 410                 415     


Ser Gln Ala Ile Gly Phe Leu Leu Gly Phe Met Ser Ile Pro Met Thr 
            420                 425                 430         


Val Gly Pro Pro Ile Ala Gly Leu Leu Arg Asp Lys Leu Gly Ser Tyr 
        435                 440                 445             


Asp Val Ala Phe Tyr Leu Ala Gly Val Pro Pro Leu Ile Gly Gly Ala 
    450                 455                 460                 


Val Leu Cys Phe Ile Pro Trp Ile His Ser Lys Lys Gln Arg Glu Ile 
465                 470                 475                 480 


Ser Lys Thr Thr Gly Lys Glu Lys Met Glu Lys Met Leu Glu Asn Gln 
                485                 490                 495     


Asn Ser Leu Leu Ser Ser Ser Ser Gly Met Phe Lys Lys Glu Ser Asp 
            500                 505                 510         


Ser Ile Ile 
        515 


<210>  4471
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  4471

Met Ala Trp Arg Gly Trp Ala Gln Arg Gly Trp Gly Cys Gly Gln Ala 
1               5                   10                  15      


Trp Gly Ala Ser Val Gly Gly Arg Ser Cys Glu Glu Leu Thr Ala Val 
            20                  25                  30          


Leu Thr Pro Pro Gln Leu Leu Gly Arg Arg Phe Asn Phe Phe Ile Gln 
        35                  40                  45              


Gln Lys Cys Gly Phe Arg Lys Ala Pro Arg Lys Val Glu Pro Arg Arg 
    50                  55                  60                  


Ser Asp Pro Gly Thr Ser Gly Glu Ala Tyr Lys Arg Ser Ala Leu Ile 
65                  70                  75                  80  


Pro Pro Val Glu Glu Thr Val Phe Tyr Pro Ser Pro Tyr Pro Ile Arg 
                85                  90                  95      


Ser Leu Ile Lys Pro Leu Phe Phe Thr Val Gly Phe Thr Gly Cys Ala 
            100                 105                 110         


Phe Gly Ser Ala Ala Ile Trp Gln Tyr Glu Ser Leu Lys Ser Arg Val 
        115                 120                 125             


Gln Ser Tyr Phe Asp Gly Ile Lys Ala Asp Trp Leu Asp Ser Ile Arg 
    130                 135                 140                 


Pro Gln Lys Glu Gly Asp Phe Arg Lys Glu Ile Asn Lys Trp Trp Asn 
145                 150                 155                 160 


Asn Leu Ser Asp Gly Gln Arg Thr Val Thr Gly Ile Ile Ala Ala Asn 
                165                 170                 175     


Val Leu Val Phe Cys Leu Trp Arg Val Pro Ser Leu Gln Arg Thr Met 
            180                 185                 190         


Ile Arg Tyr Phe Thr Ser Asn Pro Ala Ser Lys Val Leu Cys Ser Pro 
        195                 200                 205             


Met Leu Leu Ser Thr Phe Ser His Phe Ser Leu Phe His Met Ala Ala 
    210                 215                 220                 


Asn Met Tyr Val Leu Trp Ser Phe Ser Ser Ser Ile Val Asn Ile Leu 
225                 230                 235                 240 


Gly Gln Glu Gln Phe Met Ala Val Tyr Leu Ser Ala Gly Val Ile Ser 
                245                 250                 255     


Asn Phe Val Ser Tyr Val Gly Lys Val Ala Thr Gly Arg Tyr Gly Pro 
            260                 265                 270         


Ser Leu Gly Ala Ser Gly Ala Ile Met Thr Val Leu Ala Ala Val Cys 
        275                 280                 285             


Thr Lys Ile Pro Glu Gly Arg Leu Ala Ile Ile Phe Leu Pro Met Phe 
    290                 295                 300                 


Thr Phe Thr Ala Gly Asn Ala Leu Lys Ala Ile Ile Ala Met Asp Thr 
305                 310                 315                 320 


Ala Gly Met Ile Leu Gly Trp Lys Phe Phe Asp His Ala Ala His Leu 
                325                 330                 335     


Gly Gly Ala Leu Phe Gly Ile Trp Tyr Val Thr Tyr Gly His Glu Leu 
            340                 345                 350         


Ile Trp Lys Asn Arg Glu Pro Leu Val Lys Ile Trp His Glu Ile Arg 
        355                 360                 365             


Thr Asn Gly Pro Lys Lys Gly Gly Gly Ser Lys 
    370                 375                 


<210>  4472
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  4472

Met Leu Cys Gly Arg Pro Arg Ser Ser Ser Asp Asn Arg Asn Phe Leu 
1               5                   10                  15      


Arg Glu Arg Ala Gly Leu Ser Ser Ala Ala Val Gln Thr Arg Ile Gly 
            20                  25                  30          


Asn Ser Ala Ala Ser Arg Arg Ser Pro Ala Ala Arg Pro Pro Val Pro 
        35                  40                  45              


Ala Pro Pro Ala Leu Pro Arg Gly Arg Pro Gly Thr Glu Gly Ser Thr 
    50                  55                  60                  


Ser Leu Ser Ala Pro Ala Val Leu Val Val Ala Val Ala Val Val Val 
65                  70                  75                  80  


Val Val Val Ser Ala Val Ala Trp Ala Met Ala Asn Tyr Ile His Val 
                85                  90                  95      


Pro Pro Gly Ser Pro Glu Val Pro Lys Leu Asn Val Thr Val Gln Asp 
            100                 105                 110         


Gln Glu Glu His Arg Cys Arg Glu Gly Ala Leu Ser Leu Leu Gln His 
        115                 120                 125             


Leu Arg Pro His Trp Asp Pro Gln Glu Val Thr Leu Gln Leu Phe Thr 
    130                 135                 140                 


Asp Gly Ile Thr Asn Lys Leu Ile Gly Cys Tyr Val Gly Asn Thr Met 
145                 150                 155                 160 


Glu Asp Val Val Leu Val Arg Ile Tyr Gly Asn Lys Thr Glu Leu Leu 
                165                 170                 175     


Val Asp Arg Asp Glu Glu Val Lys Ser Phe Arg Val Leu Gln Ala His 
            180                 185                 190         


Gly Cys Ala Pro Gln Leu Tyr Cys Thr Phe Asn Asn Gly Leu Cys Tyr 
        195                 200                 205             


Glu Phe Ile Gln Gly Glu Ala Leu Asp Pro Lys His Val Cys Asn Pro 
    210                 215                 220                 


Ala Ile Phe Arg Leu Ile Ala Arg Gln Leu Ala Lys Ile His Ala Ile 
225                 230                 235                 240 


His Ala His Asn Gly Trp Ile Pro Lys Ser Asn Leu Trp Leu Lys Met 
                245                 250                 255     


Gly Lys Tyr Phe Ser Leu Ile Pro Thr Gly Phe Ala Asp Glu Asp Ile 
            260                 265                 270         


Asn Lys Arg Phe Leu Ser Asp Ile Pro Ser Ser Gln Ile Leu Gln Glu 
        275                 280                 285             


Glu Met Thr Trp Met Lys Glu Ile Leu Ser Asn Leu Gly Ser Pro Val 
    290                 295                 300                 


Val Leu Cys His Asn Asp Leu Leu Cys Lys Asn Ile Ile Tyr Asn Glu 
305                 310                 315                 320 


Lys Gln Gly Asp Val Gln Phe Ile Asp Tyr Glu Tyr Ser Gly Tyr Asn 
                325                 330                 335     


Tyr Leu Ala Tyr Asp Ile Gly Asn His Phe Asn Glu Phe Ala Gly Val 
            340                 345                 350         


Ser Asp Val Asp Tyr Ser Leu Tyr Pro Asp Arg Glu Leu Gln Ser Gln 
        355                 360                 365             


Trp Leu Arg Ala Tyr Leu Glu Ala Tyr Lys Glu Phe Lys Gly Phe Gly 
    370                 375                 380                 


Thr Glu Val Thr Glu Lys Glu Val Glu Ile Leu Phe Ile Gln Val Asn 
385                 390                 395                 400 


Gln Phe Ala Leu Ala Ser His Phe Phe Trp Gly Leu Trp Ala Leu Ile 
                405                 410                 415     


Gln Ala Lys Tyr Ser Thr Ile Glu Phe Asp Phe Leu Gly Tyr Ala Ile 
            420                 425                 430         


Val Arg Phe Asn Gln Tyr Phe Lys Met Lys Pro Glu Val Thr Ala Leu 
        435                 440                 445             


Lys Val Pro Glu 
    450         


<210>  4473
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  4473

Met Thr Lys Ala Arg Leu Phe Arg Leu Trp Leu Val Leu Gly Ser Val 
1               5                   10                  15      


Phe Met Ile Leu Leu Ile Ile Val Tyr Trp Asp Ser Ala Gly Ala Ala 
            20                  25                  30          


His Phe Tyr Leu His Thr Ser Phe Ser Arg Pro His Thr Gly Pro Pro 
        35                  40                  45              


Leu Pro Thr Pro Gly Pro Asp Arg Asp Arg Glu Leu Thr Ala Asp Ser 
    50                  55                  60                  


Asp Val Asp Glu Phe Leu Asp Lys Phe Leu Ser Ala Gly Val Lys Gln 
65                  70                  75                  80  


Ser Asp Leu Pro Arg Lys Glu Thr Glu Gln Pro Pro Ala Pro Gly Ser 
                85                  90                  95      


Met Glu Glu Ser Val Arg Gly Tyr Asp Trp Ser Pro Arg Asp Ala Arg 
            100                 105                 110         


Arg Ser Pro Asp Gln Gly Arg Gln Gln Ala Glu Arg Arg Ser Val Leu 
        115                 120                 125             


Arg Gly Phe Cys Ala Asn Ser Ser Leu Ala Phe Pro Thr Lys Glu Arg 
    130                 135                 140                 


Ala Phe Asp Asp Ile Pro Asn Ser Glu Leu Ser His Leu Ile Val Asp 
145                 150                 155                 160 


Asp Arg His Gly Ala Ile Tyr Cys Tyr Val Pro Lys Val Ala Cys Thr 
                165                 170                 175     


Asn Trp Lys Arg Val Met Ile Val Leu Ser Gly Ser Leu Leu His Arg 
            180                 185                 190         


Gly Ala Pro Tyr Arg Asp Pro Leu Arg Ile Pro Arg Glu His Val His 
        195                 200                 205             


Asn Ala Ser Ala His Leu Thr Phe Asn Lys Phe Trp Arg Arg Tyr Gly 
    210                 215                 220                 


Lys Leu Ser Arg His Leu Met Lys Val Lys Leu Lys Lys Tyr Thr Lys 
225                 230                 235                 240 


Phe Leu Phe Val Arg Asp Pro Phe Val Arg Leu Ile Ser Ala Phe Arg 
                245                 250                 255     


Ser Lys Phe Glu Leu Glu Asn Glu Glu Phe Tyr Arg Lys Phe Ala Val 
            260                 265                 270         


Pro Met Leu Arg Leu Tyr Ala Asn His Thr Ser Leu Pro Ala Ser Ala 
        275                 280                 285             


Arg Glu Ala Phe Arg Ala Gly Leu Lys Val Ser Phe Ala Asn Phe Ile 
    290                 295                 300                 


Gln Tyr Leu Leu Asp Pro His Thr Glu Lys Leu Ala Pro Phe Asn Glu 
305                 310                 315                 320 


His Trp Arg Gln Val Tyr Arg Leu Cys His Pro Cys Gln Ile Asp Tyr 
                325                 330                 335     


Asp Phe Val Gly Lys Leu Glu Thr Leu Asp Glu Asp Ala Ala Gln Leu 
            340                 345                 350         


Leu Gln Leu Leu Gln Val Asp Arg Gln Leu Arg Phe Pro Pro Ser Tyr 
        355                 360                 365             


Arg Asn Arg Thr Ala Ser Ser Trp Glu Glu Asp Trp Phe Ala Lys Ile 
    370                 375                 380                 


Pro Leu Ala Trp Arg Gln Gln Leu Tyr Lys Leu Tyr Glu Ala Asp Phe 
385                 390                 395                 400 


Val Leu Phe Gly Tyr Pro Lys Pro Glu Asn Leu Leu Arg Asp 
                405                 410                 


<210>  4474
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  4474

Met Arg Lys Thr Arg Leu Trp Gly Leu Leu Trp Met Leu Phe Val Ser 
1               5                   10                  15      


Glu Leu Arg Ala Ala Thr Lys Leu Thr Glu Glu Lys Tyr Glu Leu Lys 
            20                  25                  30          


Glu Gly Gln Thr Leu Asp Val Lys Cys Asp Tyr Thr Leu Glu Lys Phe 
        35                  40                  45              


Ala Ser Ser Gln Lys Ala Trp Gln Ile Ile Arg Asp Gly Glu Met Pro 
    50                  55                  60                  


Lys Thr Leu Ala Cys Thr Glu Arg Pro Ser Lys Asn Ser His Pro Val 
65                  70                  75                  80  


Gln Val Gly Arg Ile Ile Leu Glu Asp Tyr His Asp His Gly Leu Leu 
                85                  90                  95      


Arg Val Arg Met Val Asn Leu Gln Val Glu Asp Ser Gly Leu Tyr Gln 
            100                 105                 110         


Cys Val Ile Tyr Gln Pro Pro Lys Glu Pro His Met Leu Phe Asp Arg 
        115                 120                 125             


Ile Arg Leu Val Val Thr Lys Gly Phe Ser Gly Thr Pro Gly Ser Asn 
    130                 135                 140                 


Glu Asn Ser Thr Gln Asn Val Tyr Lys Ile Pro Pro Thr Thr Thr Lys 
145                 150                 155                 160 


Ala Leu Cys Pro Leu Tyr Thr Ser Pro Arg Thr Val Thr Gln Ala Pro 
                165                 170                 175     


Pro Lys Ser Thr Ala Asp Val Ser Thr Pro Asp Ser Glu Ile Asn Leu 
            180                 185                 190         


Thr Asn Val Thr Asp Ile Ile Arg Val Pro Val Phe Asn Ile Val Ile 
        195                 200                 205             


Leu Leu Ala Gly Gly Phe Leu Ser Lys Ser Leu Val Phe Ser Val Leu 
    210                 215                 220                 


Phe Ala Val Thr Leu Arg Ser Phe Val Pro 
225                 230                 


<210>  4475
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  4475

Met Pro Lys Arg Arg Asp Ile Leu Ala Ile Val Leu Ile Val Leu Pro 
1               5                   10                  15      


Trp Thr Leu Leu Ile Thr Val Trp His Gln Ser Thr Leu Ala Pro Leu 
            20                  25                  30          


Leu Ala Val His Lys Asp Glu Gly Ser Asp Pro Arg Arg Glu Thr Pro 
        35                  40                  45              


Pro Gly Ala Asp Pro Arg Glu Tyr Cys Thr Ser Asp Arg Asp Ile Val 
    50                  55                  60                  


Glu Val Val Arg Thr Glu Tyr Val Tyr Thr Arg Pro Pro Pro Trp Ser 
65                  70                  75                  80  


Asp Thr Leu Pro Thr Ile His Val Val Thr Pro Thr Tyr Ser Arg Pro 
                85                  90                  95      


Val Gln Lys Ala Glu Leu Thr Arg Met Ala Asn Thr Leu Leu His Val 
            100                 105                 110         


Pro Asn Leu His Trp Leu Val Val Glu Asp Ala Pro Arg Arg Thr Pro 
        115                 120                 125             


Leu Thr Ala Arg Leu Leu Arg Asp Thr Gly Leu Asn Tyr Thr His Leu 
    130                 135                 140                 


His Val Glu Thr Pro Arg Asn Tyr Lys Leu Arg Gly Asp Ala Arg Asp 
145                 150                 155                 160 


Pro Arg Ile Pro Arg Gly Thr Met Gln Arg Asn Leu Ala Leu Arg Trp 
                165                 170                 175     


Leu Arg Glu Thr Phe Pro Arg Asn Ser Ser Gln Pro Gly Val Val Tyr 
            180                 185                 190         


Phe Ala Asp Asp Asp Asn Thr Tyr Ser Leu Glu Leu Phe Glu Glu Met 
        195                 200                 205             


Arg Ser Thr Arg Arg Val Ser Val Trp Pro Val Ala Phe Val Gly Gly 
    210                 215                 220                 


Leu Arg Tyr Glu Ala Pro Arg Val Asn Gly Ala Gly Lys Val Val Gly 
225                 230                 235                 240 


Trp Lys Thr Val Phe Asp Pro His Arg Pro Phe Ala Ile Asp Met Ala 
                245                 250                 255     


Gly Phe Ala Val Asn Leu Arg Leu Ile Leu Gln Arg Ser Gln Ala Tyr 
            260                 265                 270         


Phe Lys Leu Arg Gly Val Lys Gly Gly Tyr Gln Glu Ser Ser Leu Leu 
        275                 280                 285             


Arg Glu Leu Val Thr Leu Asn Asp Leu Glu Pro Lys Ala Ala Asn Cys 
    290                 295                 300                 


Thr Lys Ile Leu Val Trp His Thr Arg Thr Glu Lys Pro Val Leu Val 
305                 310                 315                 320 


Asn Glu Gly Lys Lys Gly Phe Thr Asp Pro Ser Val Glu Ile 
                325                 330                 


<210>  4476
<211>  765
<212>  PRT
<213>  Homo sapiens

<400>  4476

Met Gly Pro Leu Gln Gly Asp Gly Gly Pro Ala Leu Gly Gly Ala Asp 
1               5                   10                  15      


Val Ala Pro Arg Leu Ser Pro Val Arg Val Trp Pro Arg Pro Gln Ala 
            20                  25                  30          


Pro Lys Glu Pro Ala Leu His Pro Met Gly Leu Ser Leu Pro Lys Glu 
        35                  40                  45              


Lys Gly Leu Ile Leu Cys Leu Trp Ser Lys Phe Cys Arg Trp Phe Gln 
    50                  55                  60                  


Arg Arg Glu Ser Trp Ala Gln Ser Arg Asp Glu Gln Asn Leu Leu Gln 
65                  70                  75                  80  


Gln Lys Arg Ile Trp Glu Ser Pro Leu Leu Leu Ala Ala Lys Asp Asn 
                85                  90                  95      


Asp Val Gln Ala Leu Asn Lys Leu Leu Lys Tyr Glu Asp Cys Lys Val 
            100                 105                 110         


His Gln Arg Gly Ala Met Gly Glu Thr Ala Leu His Ile Ala Ala Leu 
        115                 120                 125             


Tyr Asp Asn Leu Glu Ala Ala Met Val Leu Met Glu Ala Ala Pro Glu 
    130                 135                 140                 


Leu Val Phe Glu Pro Met Thr Ser Glu Leu Tyr Glu Gly Gln Thr Ala 
145                 150                 155                 160 


Leu His Ile Ala Val Val Asn Gln Asn Met Asn Leu Val Arg Ala Leu 
                165                 170                 175     


Leu Ala Arg Arg Ala Ser Val Ser Ala Arg Ala Thr Gly Thr Ala Phe 
            180                 185                 190         


Arg Arg Ser Pro Cys Asn Leu Ile Tyr Phe Gly Glu His Pro Leu Ser 
        195                 200                 205             


Phe Ala Ala Cys Val Asn Ser Glu Glu Ile Val Arg Leu Leu Ile Glu 
    210                 215                 220                 


His Gly Ala Asp Ile Arg Ala Gln Asp Ser Leu Gly Asn Thr Val Leu 
225                 230                 235                 240 


His Ile Leu Ile Leu Gln Pro Asn Lys Thr Phe Ala Cys Gln Met Tyr 
                245                 250                 255     


Asn Leu Leu Leu Ser Tyr Asp Arg His Gly Asp His Leu Gln Pro Leu 
            260                 265                 270         


Asp Leu Val Pro Asn His Gln Gly Leu Thr Pro Phe Lys Leu Ala Gly 
        275                 280                 285             


Val Glu Gly Asn Thr Val Met Phe Gln His Leu Met Gln Lys Arg Lys 
    290                 295                 300                 


His Thr Gln Trp Thr Tyr Gly Pro Leu Thr Ser Thr Leu Tyr Asp Leu 
305                 310                 315                 320 


Thr Glu Ile Asp Ser Ser Gly Asp Glu Gln Ser Leu Leu Glu Leu Ile 
                325                 330                 335     


Ile Thr Thr Lys Lys Arg Glu Ala Arg Gln Ile Leu Asp Gln Thr Pro 
            340                 345                 350         


Val Lys Glu Leu Val Ser Leu Lys Trp Lys Arg Tyr Gly Arg Pro Tyr 
        355                 360                 365             


Phe Cys Met Leu Gly Ala Ile Tyr Leu Leu Tyr Ile Ile Cys Phe Thr 
    370                 375                 380                 


Met Cys Cys Ile Tyr Arg Pro Leu Lys Pro Arg Thr Asn Asn Arg Thr 
385                 390                 395                 400 


Ser Pro Arg Asp Asn Thr Leu Leu Gln Gln Lys Leu Leu Gln Glu Ala 
                405                 410                 415     


Tyr Met Thr Pro Lys Asp Asp Ile Arg Leu Val Gly Glu Leu Val Thr 
            420                 425                 430         


Val Ile Gly Ala Ile Ile Ile Leu Leu Val Glu Val Pro Asp Ile Phe 
        435                 440                 445             


Arg Met Gly Val Thr Arg Phe Phe Gly Gln Thr Ile Leu Gly Gly Pro 
    450                 455                 460                 


Phe His Val Leu Ile Ile Thr Tyr Ala Phe Met Val Leu Val Thr Met 
465                 470                 475                 480 


Val Met Arg Leu Ile Ser Ala Ser Gly Glu Val Val Pro Met Ser Phe 
                485                 490                 495     


Ala Leu Val Leu Gly Trp Cys Asn Val Met Tyr Phe Ala Arg Gly Phe 
            500                 505                 510         


Gln Met Leu Gly Pro Phe Thr Ile Met Ile Gln Lys Met Ile Phe Gly 
        515                 520                 525             


Asp Leu Met Arg Phe Cys Trp Leu Met Ala Val Val Ile Leu Gly Phe 
    530                 535                 540                 


Ala Ser Ala Phe Tyr Ile Ile Phe Gln Thr Glu Asp Pro Glu Glu Leu 
545                 550                 555                 560 


Gly His Phe Tyr Asp Tyr Pro Met Ala Leu Phe Ser Thr Phe Glu Leu 
                565                 570                 575     


Phe Leu Thr Ile Ile Asp Gly Pro Ala Asn Tyr Asn Val Asp Leu Pro 
            580                 585                 590         


Phe Met Tyr Ser Ile Thr Tyr Ala Ala Phe Ala Ile Ile Ala Thr Leu 
        595                 600                 605             


Leu Met Leu Asn Leu Leu Ile Ala Met Met Gly Asp Thr His Trp Arg 
    610                 615                 620                 


Val Ala His Glu Arg Asp Glu Leu Trp Arg Ala Gln Ile Val Ala Thr 
625                 630                 635                 640 


Thr Val Met Leu Glu Arg Lys Leu Pro Arg Cys Leu Trp Pro Arg Ser 
                645                 650                 655     


Gly Ile Cys Gly Arg Glu Tyr Gly Leu Gly Asp Arg Trp Phe Leu Arg 
            660                 665                 670         


Val Glu Asp Arg Gln Asp Leu Asn Arg Gln Arg Ile Gln Arg Tyr Ala 
        675                 680                 685             


Gln Ala Phe His Thr Arg Gly Ser Glu Asp Leu Asp Lys Asp Ser Val 
    690                 695                 700                 


Glu Lys Leu Glu Leu Gly Cys Pro Phe Ser Pro His Leu Ser Leu Pro 
705                 710                 715                 720 


Met Pro Ser Val Ser Arg Ser Thr Ser Arg Ser Ser Ala Asn Trp Glu 
                725                 730                 735     


Arg Leu Arg Gln Gly Thr Leu Arg Arg Asp Leu Arg Gly Ile Ile Asn 
            740                 745                 750         


Arg Gly Leu Glu Asp Gly Glu Ser Trp Glu Tyr Gln Ile 
        755                 760                 765 


<210>  4477
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  4477

Met Ala Leu Lys Val Leu Leu Glu Gln Glu Lys Thr Phe Phe Thr Leu 
1               5                   10                  15      


Leu Val Leu Leu Gly Tyr Leu Ser Cys Lys Val Thr Cys Glu Ser Gly 
            20                  25                  30          


Asp Cys Arg Gln Gln Glu Phe Arg Asp Arg Ser Gly Asn Cys Val Pro 
        35                  40                  45              


Cys Asn Gln Cys Gly Pro Gly Met Glu Leu Ser Lys Glu Cys Gly Phe 
    50                  55                  60                  


Gly Tyr Gly Glu Asp Ala Gln Cys Val Thr Cys Arg Leu His Arg Phe 
65                  70                  75                  80  


Lys Glu Asp Trp Gly Phe Gln Lys Cys Lys Pro Cys Leu Asp Cys Ala 
                85                  90                  95      


Val Val Asn Arg Phe Gln Lys Ala Asn Cys Ser Ala Thr Ser Asp Ala 
            100                 105                 110         


Ile Cys Gly Asp Cys Leu Pro Gly Phe Tyr Arg Lys Thr Lys Leu Val 
        115                 120                 125             


Gly Phe Gln Asp Met Glu Cys Val Pro Cys Gly Asp Pro Pro Pro Pro 
    130                 135                 140                 


Tyr Glu Pro His Cys Ala Ser Lys Val Asn Leu Val Lys Ile Ala Ser 
145                 150                 155                 160 


Thr Ala Ser Ser Pro Arg Asp Thr Ala Leu Ala Ala Val Ile Cys Ser 
                165                 170                 175     


Ala Leu Ala Thr Val Leu Leu Ala Leu Leu Ile Leu Cys Val Ile Tyr 
            180                 185                 190         


Cys Lys Arg Gln Phe Met Glu Lys Lys Pro Ser Trp Ser Leu Arg Ser 
        195                 200                 205             


Gln Asp Ile Gln Tyr Asn Gly Ser Glu Leu Ser Cys Phe Asp Arg Pro 
    210                 215                 220                 


Gln Leu His Glu Tyr Ala His Arg Ala Cys Cys Gln Cys Arg Arg Asp 
225                 230                 235                 240 


Ser Val Gln Thr Cys Gly Pro Val Arg Leu Leu Pro Ser Met Cys Cys 
                245                 250                 255     


Glu Glu Ala Cys Ser Pro Asn Pro Ala Thr Leu Gly Cys Gly Val His 
            260                 265                 270         


Ser Ala Ala Ser Leu Gln Ala Arg Asn Ala Gly Pro Ala Gly Glu Met 
        275                 280                 285             


Val Pro Thr Phe Phe Gly Ser Leu Thr Gln Ser Ile Cys Gly Glu Phe 
    290                 295                 300                 


Ser Asp Ala Trp Pro Leu Met Gln Asn Pro Met Gly Gly Asp Asn Ile 
305                 310                 315                 320 


Ser Phe Cys Asp Ser Tyr Pro Glu Leu Thr Gly Glu Asp Ile His Ser 
                325                 330                 335     


Leu Asn Pro Glu Leu Glu Ser Ser Thr Ser Leu Asp Ser Asn Ser Ser 
            340                 345                 350         


Gln Asp Leu Val Gly Gly Ala Val Pro Val Gln Ser His Ser Glu Asn 
        355                 360                 365             


Phe Thr Ala Ala Thr Asp Leu Ser Arg Tyr Asn Asn Thr Leu Val Glu 
    370                 375                 380                 


Ser Ala Ser Thr Gln Asp Ala Leu Thr Met Arg Ser Gln Leu Asp Gln 
385                 390                 395                 400 


Glu Ser Gly Ala Val Ile His Pro Ala Thr Gln Thr Ser Leu Gln Val 
                405                 410                 415     


Arg Gln Arg Leu Gly Ser Leu 
            420             


<210>  4478
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  4478

Met Gly Thr Gln Pro Glu Pro Gly Leu Gly Ala Arg Met Ala Ile His 
1               5                   10                  15      


Lys Ala Leu Val Met Cys Leu Gly Leu Pro Leu Phe Leu Phe Pro Gly 
            20                  25                  30          


Ala Trp Ala Gln Gly His Val Pro Pro Gly Cys Ser Gln Gly Leu Asn 
        35                  40                  45              


Pro Leu Tyr Tyr Asn Leu Cys Asp Arg Ser Gly Ala Trp Gly Ile Val 
    50                  55                  60                  


Leu Glu Ala Val Ala Gly Ala Gly Ile Val Thr Thr Phe Val Leu Thr 
65                  70                  75                  80  


Ile Ile Leu Val Ala Ser Leu Pro Phe Val Gln Asp Thr Lys Lys Arg 
                85                  90                  95      


Ser Leu Leu Gly Thr Gln Val Phe Phe Leu Leu Gly Thr Leu Gly Leu 
            100                 105                 110         


Phe Cys Leu Val Phe Ala Cys Val Val Lys Pro Asp Phe Ser Thr Cys 
        115                 120                 125             


Ala Ser Arg Arg Phe Leu Phe Gly Val Leu Phe Ala Ile Cys Phe Ser 
    130                 135                 140                 


Cys Leu Ala Ala His Val Phe Ala Leu Asn Phe Leu Ala Arg Lys Asn 
145                 150                 155                 160 


His Gly Pro Arg Gly Trp Val Ile Phe Thr Val Ala Leu Leu Leu Thr 
                165                 170                 175     


Leu Val Glu Val Ile Ile Asn Thr Glu Trp Leu Ile Ile Thr Leu Val 
            180                 185                 190         


Arg Gly Ser Gly Glu Gly Gly Pro Gln Gly Asn Ser Ser Ala Gly Trp 
        195                 200                 205             


Ala Val Ala Ser Pro Cys Ala Ile Ala Asn Met Asp Phe Val Met Ala 
    210                 215                 220                 


Leu Ile Tyr Val Met Leu Leu Leu Leu Gly Ala Phe Leu Gly Ala Trp 
225                 230                 235                 240 


Pro Ala Leu Cys Gly Arg Tyr Lys Arg Trp Arg Lys His Gly Val Phe 
                245                 250                 255     


Val Leu Leu Thr Thr Ala Thr Ser Val Ala Ile Trp Val Val Trp Ile 
            260                 265                 270         


Val Met Tyr Thr Tyr Gly Asn Lys Gln His Asn Ser Pro Thr Trp Asp 
        275                 280                 285             


Asp Pro Thr Leu Ala Ile Ala Leu Ala Ala Asn Ala Trp Ala Phe Val 
    290                 295                 300                 


Leu Phe Tyr Val Ile Pro Glu Val Ser Gln Val Thr Lys Ser Ser Pro 
305                 310                 315                 320 


Glu Gln Ser Tyr Gln Gly Asp Met Tyr Pro Thr Arg Gly Val Gly Tyr 
                325                 330                 335     


Glu Thr Ile Leu Lys Glu Gln Lys Gly Gln Ser Met Phe Val Glu Asn 
            340                 345                 350         


Lys Ala Phe Ser Met Asp Glu Pro Val Ala Ala Lys Arg Pro Val Ser 
        355                 360                 365             


Pro Tyr Ser Gly Tyr Asn Gly Gln Leu Leu Thr Ser Val Tyr Gln Pro 
    370                 375                 380                 


Thr Glu Met Ala Leu Met His Lys Val Pro Ser Glu Gly Ala Tyr Asp 
385                 390                 395                 400 


Ile Ile Leu Pro Arg Ala Thr Ala Asn Ser Gln Val Met Gly Ser Ala 
                405                 410                 415     


Asn Ser Thr Leu Arg Ala Glu Asp Met Tyr Ser Ala Gln Ser His Gln 
            420                 425                 430         


Ala Ala Thr Pro Pro Lys Asp Gly Lys Asn Ser Gln Val Phe Arg Asn 
        435                 440                 445             


Pro Tyr Val Trp Asp 
    450             


<210>  4479
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  4479

Met Tyr Lys Asp Cys Ile Glu Ser Thr Gly Asp Tyr Phe Leu Leu Cys 
1               5                   10                  15      


Asp Ala Glu Gly Pro Trp Gly Ile Ile Leu Glu Ser Leu Ala Ile Leu 
            20                  25                  30          


Gly Ile Val Val Thr Ile Leu Leu Leu Leu Ala Phe Leu Phe Leu Met 
        35                  40                  45              


Arg Lys Ile Gln Asp Cys Ser Gln Trp Asn Val Leu Pro Thr Gln Leu 
    50                  55                  60                  


Leu Phe Leu Leu Ser Val Leu Gly Leu Phe Gly Leu Ala Phe Ala Phe 
65                  70                  75                  80  


Ile Ile Glu Leu Asn Gln Gln Thr Ala Pro Val Arg Tyr Phe Leu Phe 
                85                  90                  95      


Gly Val Leu Phe Ala Leu Cys Phe Ser Cys Leu Leu Ala His Ala Ser 
            100                 105                 110         


Asn Leu Val Lys Leu Val Arg Gly Cys Val Ser Phe Ser Trp Thr Thr 
        115                 120                 125             


Ile Leu Cys Ile Ala Ile Gly Cys Ser Leu Leu Gln Ile Ile Ile Ala 
    130                 135                 140                 


Thr Glu Tyr Val Thr Leu Ile Met Thr Arg Gly Met Met Phe Val Asn 
145                 150                 155                 160 


Met Thr Pro Cys Gln Leu Asn Val Asp Phe Val Val Leu Leu Val Tyr 
                165                 170                 175     


Val Leu Phe Leu Met Ala Leu Thr Phe Phe Val Ser Lys Ala Thr Phe 
            180                 185                 190         


Cys Gly Pro Cys Glu Asn Trp Lys Gln His Gly Arg Leu Ile Phe Ile 
        195                 200                 205             


Thr Val Leu Phe Ser Ile Ile Ile Trp Val Val Trp Ile Ser Met Leu 
    210                 215                 220                 


Leu Arg Gly Asn Pro Gln Phe Gln Arg Gln Pro Gln Trp Asp Asp Pro 
225                 230                 235                 240 


Val Val Cys Ile Ala Leu Val Thr Asn Ala Trp Val Phe Leu Leu Leu 
                245                 250                 255     


Tyr Ile Val Pro Glu Leu Cys Ile Leu Tyr Arg Ser Cys Arg Gln Glu 
            260                 265                 270         


Cys Pro Leu Gln Gly Asn Ala Cys Pro Val Thr Ala Tyr Gln His Ser 
        275                 280                 285             


Phe Gln Val Glu Asn Gln Glu Leu Ser Arg Ala Arg Asp Ser Asp Gly 
    290                 295                 300                 


Ala Glu Glu Asp Val Ala Leu Thr Ser Tyr Gly Thr Pro Ile Gln Pro 
305                 310                 315                 320 


Gln Thr Val Asp Pro Thr Gln Glu Cys Phe Ile Pro Gln Ala Lys Leu 
                325                 330                 335     


Ser Pro Gln Gln Asp Ala Gly Gly Val 
            340                 345 


<210>  4480
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  4480

Met Ala Leu Leu Val Asp Arg Val Arg Gly His Trp Arg Ile Ala Ala 
1               5                   10                  15      


Gly Leu Leu Phe Asn Leu Leu Val Ser Ile Cys Ile Val Phe Leu Asn 
            20                  25                  30          


Lys Trp Ile Tyr Val Tyr His Gly Phe Pro Asn Met Ser Leu Thr Leu 
        35                  40                  45              


Val His Phe Val Val Thr Trp Leu Gly Leu Tyr Ile Cys Gln Lys Leu 
    50                  55                  60                  


Asp Ile Phe Ala Pro Lys Ser Leu Pro Pro Ser Arg Leu Leu Leu Leu 
65                  70                  75                  80  


Ala Leu Ser Phe Cys Gly Phe Val Val Phe Thr Asn Leu Ser Leu Gln 
                85                  90                  95      


Asn Asn Thr Ile Gly Thr Tyr Gln Leu Ala Lys Ala Met Thr Thr Pro 
            100                 105                 110         


Val Ile Ile Ala Ile Gln Thr Phe Cys Tyr Gln Lys Thr Phe Ser Thr 
        115                 120                 125             


Arg Ile Gln Leu Thr Leu Ile Pro Ile Thr Leu Gly Val Ile Leu Asn 
    130                 135                 140                 


Ser Tyr Tyr Asp Val Lys Phe Asn Phe Leu Gly Met Val Phe Ala Ala 
145                 150                 155                 160 


Leu Gly Val Leu Val Thr Ser Leu Tyr Gln Val Trp Val Gly Ala Lys 
                165                 170                 175     


Gln His Glu Leu Gln Val Asn Ser Met Gln Leu Leu Tyr Tyr Gln Ala 
            180                 185                 190         


Pro Met Ser Ser Ala Met Leu Leu Val Ala Val Pro Phe Phe Glu Pro 
        195                 200                 205             


Val Phe Gly Glu Gly Gly Ile Phe Gly Pro Trp Ser Val Ser Ala Leu 
    210                 215                 220                 


Leu Met Val Leu Leu Ser Gly Val Ile Ala Phe Met Val Asn Leu Ser 
225                 230                 235                 240 


Ile Tyr Trp Ile Ile Gly Asn Thr Ser Pro Val Thr Tyr Asn Met Phe 
                245                 250                 255     


Gly His Phe Lys Phe Cys Ile Thr Leu Phe Gly Gly Tyr Val Leu Phe 
            260                 265                 270         


Lys Asp Pro Leu Ser Ile Asn Gln Ala Leu Gly Ile Leu Cys Thr Leu 
        275                 280                 285             


Phe Gly Ile Leu Ala Tyr Thr His Phe Lys Leu Ser Glu Gln Glu Gly 
    290                 295                 300                 


Ser Arg Ser Lys Leu Ala Gln Arg Pro 
305                 310             


<210>  4481
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  4481

Met Leu Lys Met Val Leu Thr Glu Asn Pro Asn Gln Glu Ile Ala Thr 
1               5                   10                  15      


Ser Leu Glu Phe Leu Leu Leu Gln Asn Ser Pro Gly Ser Leu Arg Ala 
            20                  25                  30          


Gln Gln Arg Met Ser Tyr Tyr Gly Ser Ser Tyr His Ile Ile Asn Ala 
        35                  40                  45              


Asp Ala Lys Tyr Pro Gly Tyr Pro Pro Glu His Ile Ile Ala Glu Lys 
    50                  55                  60                  


Arg Arg Ala Arg Arg Arg Leu Leu His Lys Asp Gly Ser Cys Asn Val 
65                  70                  75                  80  


Tyr Phe Lys His Ile Phe Gly Glu Trp Gly Ser Tyr Val Val Asp Ile 
                85                  90                  95      


Phe Thr Thr Leu Val Asp Thr Lys Trp Arg His Met Phe Val Ile Phe 
            100                 105                 110         


Ser Leu Ser Tyr Ile Leu Ser Trp Leu Ile Phe Gly Ser Val Phe Trp 
        115                 120                 125             


Leu Ile Ala Phe His His Gly Asp Leu Leu Asn Asp Pro Asp Ile Thr 
    130                 135                 140                 


Pro Cys Val Asp Asn Val His Ser Phe Thr Gly Ala Phe Leu Phe Ser 
145                 150                 155                 160 


Leu Glu Thr Gln Thr Thr Ile Gly Tyr Gly Tyr Arg Cys Val Thr Glu 
                165                 170                 175     


Glu Cys Ser Val Ala Val Leu Met Val Ile Leu Gln Ser Ile Leu Ser 
            180                 185                 190         


Cys Ile Ile Asn Thr Phe Ile Ile Gly Ala Ala Leu Ala Lys Met Ala 
        195                 200                 205             


Thr Ala Arg Lys Arg Ala Gln Thr Ile Arg Phe Ser Tyr Phe Ala Leu 
    210                 215                 220                 


Ile Gly Met Arg Asp Gly Lys Leu Cys Leu Met Trp Arg Ile Gly Asp 
225                 230                 235                 240 


Phe Arg Pro Asn His Val Val Glu Gly Thr Val Arg Ala Gln Leu Leu 
                245                 250                 255     


Arg Tyr Thr Glu Asp Ser Glu Gly Arg Met Thr Met Ala Phe Lys Asp 
            260                 265                 270         


Leu Lys Leu Val Asn Asp Gln Ile Ile Leu Val Thr Pro Val Thr Ile 
        275                 280                 285             


Val His Glu Ile Asp His Glu Ser Pro Leu Tyr Ala Leu Asp Arg Lys 
    290                 295                 300                 


Ala Val Ala Lys Asp Asn Phe Glu Ile Leu Val Thr Phe Ile Tyr Thr 
305                 310                 315                 320 


Gly Asp Ser Thr Gly Thr Ser His Gln Ser Arg Ser Ser Tyr Val Pro 
                325                 330                 335     


Arg Glu Ile Leu Trp Gly His Arg Phe Asn Asp Val Leu Glu Val Lys 
            340                 345                 350         


Arg Lys Tyr Tyr Lys Val Asn Cys Leu Gln Phe Glu Gly Ser Val Glu 
        355                 360                 365             


Val Tyr Ala Pro Phe Cys Ser Ala Lys Gln Leu Asp Trp Lys Asp Gln 
    370                 375                 380                 


Gln Leu His Ile Glu Lys Ala Pro Pro Val Arg Glu Ser Cys Thr Ser 
385                 390                 395                 400 


Asp Thr Lys Ala Arg Arg Arg Ser Phe Ser Ala Val Ala Ile Val Ser 
                405                 410                 415     


Ser Cys Glu Asn Pro Glu Glu Thr Thr Thr Ser Ala Thr His Glu Tyr 
            420                 425                 430         


Arg Glu Thr Pro Tyr Gln Lys Ala Leu Leu Thr Leu Asn Arg Ile Ser 
        435                 440                 445             


Val Glu Ser Gln Met 
    450             


<210>  4482
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  4482

Met Val Leu Tyr Thr Thr Pro Phe Pro Asn Ser Cys Leu Ser Ala Leu 
1               5                   10                  15      


His Cys Val Ser Trp Ala Leu Ile Phe Pro Cys Tyr Trp Leu Val Asp 
            20                  25                  30          


Arg Leu Ala Ala Ser Phe Ile Pro Thr Thr Tyr Glu Lys Arg Gln Arg 
        35                  40                  45              


Ala Asp Asp Pro Cys Cys Leu Gln Leu Leu Cys Thr Ala Leu Phe Thr 
    50                  55                  60                  


Pro Ile Tyr Leu Ala Leu Leu Val Ala Ser Leu Pro Phe Ala Phe Leu 
65                  70                  75                  80  


Gly Phe Leu Phe Trp Ser Pro Leu Gln Ser Ala Arg Arg Pro Tyr Ile 
                85                  90                  95      


Tyr Ser Arg Leu Glu Asp Lys Gly Leu Ala Gly Gly Ala Ala Leu Leu 
            100                 105                 110         


Ser Glu Trp Lys Gly Thr Gly Pro Gly Lys Ser Phe Cys Phe Ala Thr 
        115                 120                 125             


Ala Asn Val Cys Leu Leu Pro Asp Ser Leu Ala Arg Val Asn Asn Leu 
    130                 135                 140                 


Phe Asn Thr Gln Ala Arg Ala Lys Glu Ile Gly Gln Arg Ile Arg Asn 
145                 150                 155                 160 


Gly Ala Ala Arg Pro Gln Ile Lys Ile Tyr Ile Asp Ser Pro Thr Asn 
                165                 170                 175     


Thr Ser Ile Ser Ala Ala Ser Phe Ser Ser Leu Val Ser Pro Gln Gly 
            180                 185                 190         


Gly Asp Gly Val Ala Arg Ala Val Pro Gly Ser Ile Lys Arg Thr Ala 
        195                 200                 205             


Ser Val Glu Tyr Lys Gly Asp Gly Gly Arg His Pro Gly Asp Glu Ala 
    210                 215                 220                 


Ala Asn Gly Pro Ala Ser Gly Asp Pro Val Asp Ser Ser Ser Pro Glu 
225                 230                 235                 240 


Asp Ala Cys Ile Val Arg Ile Gly Gly Glu Glu Gly Gly Arg Pro Pro 
                245                 250                 255     


Glu Ala Asp Asp Pro Val Pro Gly Gly Gln Ala Arg Asn Gly Ala Gly 
            260                 265                 270         


Gly Gly Pro Arg Gly Gln Thr Pro Asn His Asn Gln Gln Asp Gly Asp 
        275                 280                 285             


Ser Gly Ser Leu Gly Ser Pro Ser Ala Ser Arg Glu Ser Leu Val Lys 
    290                 295                 300                 


Gly Arg Ala Gly Pro Asp Thr Ser Ala Ser Gly Glu Pro Gly Ala Asn 
305                 310                 315                 320 


Ser Lys Leu Leu Tyr Lys Ala Ser Val Val Lys Lys Ala Ala Ala Arg 
                325                 330                 335     


Arg Arg Arg His Pro Asp Glu Ala Phe Asp His Glu Val Ser Ala Phe 
            340                 345                 350         


Phe Pro Ala Asn Leu Asp Phe Leu Cys Leu Gln Glu Val Phe Asp Lys 
        355                 360                 365             


Arg Ala Ala Thr Lys Leu Lys Glu Gln Leu His Gly Tyr Phe Glu Tyr 
    370                 375                 380                 


Ile Leu Tyr Asp Val Gly Val Tyr Gly Cys Gln Gly Cys Cys Ser Phe 
385                 390                 395                 400 


Lys Cys Leu Asn Ser Gly Leu Leu Phe Ala Ser Arg Tyr Pro Ile Met 
                405                 410                 415     


Asp Val Ala Tyr His Cys Tyr Pro Asn Lys Cys Asn Asp Asp Ala Leu 
            420                 425                 430         


Ala Ser Lys Gly Ala Leu Phe Leu Lys Val Gln Val Gly Ser Thr Pro 
        435                 440                 445             


Gln Asp Gln Arg Ile Val Gly Tyr Ile Ala Cys Thr His Leu His Ala 
    450                 455                 460                 


Pro Gln Glu Asp Ser Ala Ile Arg Cys Gly Gln Leu Asp Leu Leu Gln 
465                 470                 475                 480 


Asp Trp Leu Ala Asp Phe Arg Lys Ser Thr Ser Ser Ser Ser Ala Ala 
                485                 490                 495     


Asn Pro Glu Glu Leu Val Ala Phe Asp Val Val Cys Gly Asp Phe Asn 
            500                 505                 510         


Phe Asp Asn Cys Ser Ser Asp Asp Lys Leu Glu Gln Gln His Ser Leu 
        515                 520                 525             


Phe Thr His Tyr Arg Asp Pro Cys Arg Leu Gly Pro Gly Glu Glu Lys 
    530                 535                 540                 


Pro Trp Ala Ile Gly Thr Leu Leu Asp Thr Asn Gly Leu Tyr Asp Glu 
545                 550                 555                 560 


Asp Val Cys Thr Pro Asp Asn Leu Gln Lys Val Leu Glu Ser Glu Glu 
                565                 570                 575     


Gly Arg Arg Glu Tyr Leu Ala Phe Pro Thr Ser Lys Ser Ser Gly Gln 
            580                 585                 590         


Lys Gly Arg Lys Glu Leu Leu Lys Gly Asn Gly Arg Arg Ile Asp Tyr 
        595                 600                 605             


Met Leu His Ala Glu Glu Gly Leu Cys Pro Asp Trp Lys Ala Glu Val 
    610                 615                 620                 


Glu Glu Phe Ser Phe Ile Thr Gln Leu Ser Gly Leu Thr Asp His Leu 
625                 630                 635                 640 


Pro Val Ala Met Arg Leu Met Val Ser Ser Gly Glu Glu Glu Ala 
                645                 650                 655 


<210>  4483
<211>  1642
<212>  PRT
<213>  Homo sapiens

<400>  4483

Met Ser Thr Ala Ile Arg Glu Val Gly Val Trp Arg Gln Thr Arg Thr 
1               5                   10                  15      


Leu Leu Leu Lys Asn Tyr Leu Ile Lys Cys Arg Thr Lys Lys Ser Ser 
            20                  25                  30          


Val Gln Glu Ile Leu Phe Pro Leu Phe Phe Leu Phe Trp Leu Ile Leu 
        35                  40                  45              


Ile Ser Met Met His Pro Asn Lys Lys Tyr Glu Glu Val Pro Asn Ile 
    50                  55                  60                  


Glu Leu Asn Pro Met Asp Lys Phe Thr Leu Ser Asn Leu Ile Leu Gly 
65                  70                  75                  80  


Tyr Thr Pro Val Thr Asn Ile Thr Ser Ser Ile Met Gln Lys Val Ser 
                85                  90                  95      


Thr Asp His Leu Pro Asp Val Ile Ile Thr Glu Glu Tyr Thr Asn Glu 
            100                 105                 110         


Lys Glu Met Leu Thr Ser Ser Leu Ser Lys Pro Ser Asn Phe Val Gly 
        115                 120                 125             


Val Val Phe Lys Asp Ser Met Ser Tyr Glu Leu Arg Phe Phe Pro Asp 
    130                 135                 140                 


Met Ile Pro Val Ser Ser Ile Tyr Met Asp Ser Arg Ala Gly Cys Ser 
145                 150                 155                 160 


Lys Ser Cys Glu Ala Ala Gln Tyr Trp Ser Ser Gly Phe Thr Val Leu 
                165                 170                 175     


Gln Ala Ser Ile Asp Ala Ala Ile Ile Gln Leu Lys Thr Asn Val Ser 
            180                 185                 190         


Leu Trp Lys Glu Leu Glu Ser Thr Lys Ala Val Ile Met Gly Glu Thr 
        195                 200                 205             


Ala Val Val Glu Ile Asp Thr Phe Pro Arg Gly Val Ile Leu Ile Tyr 
    210                 215                 220                 


Leu Val Ile Ala Phe Ser Pro Phe Gly Tyr Phe Leu Ala Ile His Ile 
225                 230                 235                 240 


Val Ala Glu Lys Glu Lys Lys Ile Lys Glu Phe Leu Lys Ile Met Gly 
                245                 250                 255     


Leu His Asp Thr Ala Phe Trp Leu Ser Trp Val Leu Leu Tyr Thr Ser 
            260                 265                 270         


Leu Ile Phe Leu Met Ser Leu Leu Met Ala Val Ile Ala Thr Ala Ser 
        275                 280                 285             


Leu Leu Phe Pro Gln Ser Ser Ser Ile Val Ile Phe Leu Leu Phe Phe 
    290                 295                 300                 


Leu Tyr Gly Leu Ser Ser Val Phe Phe Ala Leu Met Leu Thr Pro Leu 
305                 310                 315                 320 


Phe Lys Lys Ser Lys His Val Gly Ile Val Glu Phe Phe Val Thr Val 
                325                 330                 335     


Ala Phe Gly Phe Ile Gly Leu Met Ile Ile Leu Ile Glu Ser Phe Pro 
            340                 345                 350         


Lys Ser Leu Val Trp Leu Phe Ser Pro Phe Cys His Cys Thr Phe Val 
        355                 360                 365             


Ile Gly Ile Ala Gln Val Met His Leu Glu Asp Phe Asn Glu Gly Ala 
    370                 375                 380                 


Ser Phe Ser Asn Leu Thr Ala Gly Pro Tyr Pro Leu Ile Ile Thr Ile 
385                 390                 395                 400 


Ile Met Leu Thr Leu Asn Ser Ile Phe Tyr Val Leu Leu Ala Val Tyr 
                405                 410                 415     


Leu Asp Gln Val Ile Pro Gly Glu Phe Gly Leu Arg Arg Ser Ser Leu 
            420                 425                 430         


Tyr Phe Leu Lys Pro Ser Tyr Trp Ser Lys Ser Lys Arg Asn Tyr Glu 
        435                 440                 445             


Glu Leu Ser Glu Gly Asn Val Asn Gly Asn Ile Ser Phe Ser Glu Ile 
    450                 455                 460                 


Ile Glu Pro Val Ser Ser Glu Phe Val Gly Lys Glu Ala Ile Arg Ile 
465                 470                 475                 480 


Ser Gly Ile Gln Lys Thr Tyr Arg Lys Lys Gly Glu Asn Val Glu Ala 
                485                 490                 495     


Leu Arg Asn Leu Ser Phe Asp Ile Tyr Glu Gly Gln Ile Thr Ala Leu 
            500                 505                 510         


Leu Gly His Ser Gly Thr Gly Lys Ser Thr Leu Met Asn Ile Leu Cys 
        515                 520                 525             


Gly Leu Cys Pro Pro Ser Asp Gly Phe Ala Ser Ile Tyr Gly His Arg 
    530                 535                 540                 


Val Ser Glu Ile Asp Glu Met Phe Glu Ala Arg Lys Met Ile Gly Ile 
545                 550                 555                 560 


Cys Pro Gln Leu Asp Ile His Phe Asp Val Leu Thr Val Glu Glu Asn 
                565                 570                 575     


Leu Ser Ile Leu Ala Ser Ile Lys Gly Ile Pro Ala Asn Asn Ile Ile 
            580                 585                 590         


Gln Glu Val Gln Lys Val Leu Leu Asp Leu Asp Met Gln Thr Ile Lys 
        595                 600                 605             


Asp Asn Gln Ala Lys Lys Leu Ser Gly Gly Gln Lys Arg Lys Leu Ser 
    610                 615                 620                 


Leu Gly Ile Ala Val Leu Gly Asn Pro Lys Ile Leu Leu Leu Asp Glu 
625                 630                 635                 640 


Pro Thr Ala Gly Met Asp Pro Cys Ser Arg His Ile Val Trp Asn Leu 
                645                 650                 655     


Leu Lys Tyr Arg Lys Ala Asn Arg Val Thr Val Phe Ser Thr His Phe 
            660                 665                 670         


Met Asp Glu Ala Asp Ile Leu Ala Asp Arg Lys Ala Val Ile Ser Gln 
        675                 680                 685             


Gly Met Leu Lys Cys Val Gly Ser Ser Met Phe Leu Lys Ser Lys Trp 
    690                 695                 700                 


Gly Ile Gly Tyr Arg Leu Ser Met Tyr Ile Asp Lys Tyr Cys Ala Thr 
705                 710                 715                 720 


Glu Ser Leu Ser Ser Leu Val Lys Gln His Ile Pro Gly Ala Thr Leu 
                725                 730                 735     


Leu Gln Gln Asn Asp Gln Gln Leu Val Tyr Ser Leu Pro Phe Lys Asp 
            740                 745                 750         


Met Asp Lys Phe Ser Gly Leu Phe Ser Ala Leu Asp Ser His Ser Asn 
        755                 760                 765             


Leu Gly Val Ile Ser Tyr Gly Val Ser Met Thr Thr Leu Glu Asp Val 
    770                 775                 780                 


Phe Leu Lys Leu Glu Val Glu Ala Glu Ile Asp Gln Ala Asp Tyr Ser 
785                 790                 795                 800 


Val Phe Thr Gln Gln Pro Leu Glu Glu Glu Met Asp Ser Lys Ser Phe 
                805                 810                 815     


Asp Glu Met Glu Gln Ser Leu Leu Ile Leu Ser Glu Thr Lys Ala Ala 
            820                 825                 830         


Leu Val Ser Thr Met Ser Leu Trp Lys Gln Gln Met Tyr Thr Ile Ala 
        835                 840                 845             


Lys Phe His Phe Phe Thr Leu Lys Arg Glu Ser Lys Ser Val Arg Ser 
    850                 855                 860                 


Val Leu Leu Leu Leu Leu Ile Phe Phe Thr Val Gln Ile Phe Met Phe 
865                 870                 875                 880 


Leu Val His His Ser Phe Lys Asn Ala Val Val Pro Ile Lys Leu Val 
                885                 890                 895     


Pro Asp Leu Tyr Phe Leu Lys Pro Gly Asp Lys Pro His Lys Tyr Lys 
            900                 905                 910         


Thr Ser Leu Leu Leu Gln Asn Ser Ala Asp Ser Asp Ile Ser Asp Leu 
        915                 920                 925             


Ile Ser Phe Phe Thr Ser Gln Asn Ile Met Val Thr Met Ile Asn Asp 
    930                 935                 940                 


Ser Asp Tyr Val Ser Val Ala Pro His Ser Ala Ala Leu Asn Val Met 
945                 950                 955                 960 


His Ser Glu Lys Asp Tyr Val Phe Ala Ala Val Phe Asn Ser Thr Met 
                965                 970                 975     


Val Tyr Ser Leu Pro Ile Leu Val Asn Ile Ile Ser Asn Tyr Tyr Leu 
            980                 985                 990         


Tyr His Leu Asn Val Thr Glu Thr  Ile Gln Ile Trp Ser  Thr Pro Phe 
        995                 1000                 1005             


Phe Gln  Glu Ile Thr Asp Ile  Val Phe Lys Ile Glu  Leu Tyr Phe 
    1010                 1015                 1020             


Gln Ala  Ala Leu Leu Gly Ile  Ile Val Thr Ala Met  Pro Pro Tyr 
    1025                 1030                 1035             


Phe Ala  Met Glu Asn Ala Glu  Asn His Lys Ile Lys  Ala Tyr Thr 
    1040                 1045                 1050             


Gln Leu  Lys Leu Ser Gly Leu  Leu Pro Ser Ala Tyr  Trp Ile Gly 
    1055                 1060                 1065             


Gln Ala  Val Val Asp Ile Pro  Leu Phe Phe Ile Ile  Leu Ile Leu 
    1070                 1075                 1080             


Met Leu  Gly Ser Leu Leu Ala  Phe His Tyr Gly Leu  Tyr Phe Tyr 
    1085                 1090                 1095             


Thr Val  Lys Phe Leu Ala Val  Val Phe Cys Leu Ile  Gly Tyr Val 
    1100                 1105                 1110             


Pro Ser  Val Ile Leu Phe Thr  Tyr Ile Ala Ser Phe  Thr Phe Lys 
    1115                 1120                 1125             


Lys Ile  Leu Asn Thr Lys Glu  Phe Trp Ser Phe Ile  Tyr Ser Val 
    1130                 1135                 1140             


Ala Ala  Leu Ala Cys Ile Ala  Ile Thr Glu Ile Thr  Phe Phe Met 
    1145                 1150                 1155             


Gly Tyr  Thr Ile Ala Thr Ile  Leu His Tyr Ala Phe  Cys Ile Ile 
    1160                 1165                 1170             


Ile Pro  Ile Tyr Pro Leu Leu  Gly Cys Leu Ile Ser  Phe Ile Lys 
    1175                 1180                 1185             


Ile Ser  Trp Lys Asn Val Arg  Lys Asn Val Asp Thr  Tyr Asn Pro 
    1190                 1195                 1200             


Trp Asp  Arg Leu Ser Val Ala  Val Ile Ser Pro Tyr  Leu Gln Cys 
    1205                 1210                 1215             


Val Leu  Trp Ile Phe Leu Leu  Gln Tyr Tyr Glu Lys  Lys Tyr Gly 
    1220                 1225                 1230             


Gly Arg  Ser Ile Arg Lys Asp  Pro Phe Phe Arg Asn  Leu Ser Thr 
    1235                 1240                 1245             


Lys Ser  Lys Asn Arg Lys Leu  Pro Glu Pro Pro Asp  Asn Glu Asp 
    1250                 1255                 1260             


Glu Asp  Glu Asp Val Lys Ala  Glu Arg Leu Lys Val  Lys Glu Leu 
    1265                 1270                 1275             


Met Gly  Cys Gln Cys Cys Glu  Glu Lys Pro Ser Ile  Met Val Ser 
    1280                 1285                 1290             


Asn Leu  His Lys Glu Tyr Asp  Asp Lys Lys Asp Phe  Leu Leu Ser 
    1295                 1300                 1305             


Arg Lys  Val Lys Lys Val Ala  Thr Lys Tyr Ile Ser  Phe Cys Val 
    1310                 1315                 1320             


Lys Lys  Gly Glu Ile Leu Gly  Leu Leu Gly Pro Asn  Gly Ala Gly 
    1325                 1330                 1335             


Lys Ser  Thr Ile Ile Asn Ile  Leu Val Gly Asp Ile  Glu Pro Thr 
    1340                 1345                 1350             


Ser Gly  Gln Val Phe Leu Gly  Asp Tyr Ser Ser Glu  Thr Ser Glu 
    1355                 1360                 1365             


Asp Asp  Asp Ser Leu Lys Cys  Met Gly Tyr Cys Pro  Gln Ile Asn 
    1370                 1375                 1380             


Pro Leu  Trp Pro Asp Thr Thr  Leu Gln Glu His Phe  Glu Ile Tyr 
    1385                 1390                 1395             


Gly Ala  Val Lys Gly Met Ser  Ala Ser Asp Met Lys  Glu Val Ile 
    1400                 1405                 1410             


Ser Arg  Ile Thr His Ala Leu  Asp Leu Lys Glu His  Leu Gln Lys 
    1415                 1420                 1425             


Thr Val  Lys Lys Leu Pro Ala  Gly Ile Lys Arg Lys  Leu Cys Phe 
    1430                 1435                 1440             


Ala Leu  Ser Met Leu Gly Asn  Pro Gln Ile Thr Leu  Leu Asp Glu 
    1445                 1450                 1455             


Pro Ser  Thr Gly Met Asp Pro  Lys Ala Lys Gln His  Met Trp Arg 
    1460                 1465                 1470             


Ala Ile  Arg Thr Ala Phe Lys  Asn Arg Lys Arg Ala  Ala Ile Leu 
    1475                 1480                 1485             


Thr Thr  His Tyr Met Glu Glu  Ala Glu Ala Val Cys  Asp Arg Val 
    1490                 1495                 1500             


Ala Ile  Met Val Ser Gly Gln  Leu Arg Cys Ile Gly  Thr Val Gln 
    1505                 1510                 1515             


His Leu  Lys Ser Lys Phe Gly  Lys Gly Tyr Phe Leu  Glu Ile Lys 
    1520                 1525                 1530             


Leu Lys  Asp Trp Ile Glu Asn  Leu Glu Val Asp Arg  Leu Gln Arg 
    1535                 1540                 1545             


Glu Ile  Gln Tyr Ile Phe Pro  Asn Ala Ser Arg Gln  Glu Ser Phe 
    1550                 1555                 1560             


Ser Ser  Ile Leu Ala Tyr Lys  Ile Pro Lys Glu Asp  Val Gln Ser 
    1565                 1570                 1575             


Leu Ser  Gln Ser Phe Phe Lys  Leu Glu Glu Ala Lys  His Ala Phe 
    1580                 1585                 1590             


Ala Ile  Glu Glu Tyr Ser Phe  Ser Gln Ala Thr Leu  Glu Gln Val 
    1595                 1600                 1605             


Phe Val  Glu Leu Thr Lys Glu  Gln Glu Glu Glu Asp  Asn Ser Cys 
    1610                 1615                 1620             


Gly Thr  Leu Asn Ser Thr Leu  Trp Trp Glu Arg Thr  Gln Glu Asp 
    1625                 1630                 1635             


Arg Val  Val Phe 
    1640         


<210>  4484
<211>  701
<212>  PRT
<213>  Homo sapiens

<400>  4484

Met Gly Leu Pro Glu Glu Arg Val Arg Ser Gly Ser Gly Ser Arg Gly 
1               5                   10                  15      


Gln Glu Glu Ala Gly Ala Gly Gly Arg Ala Arg Ser Trp Ser Pro Pro 
            20                  25                  30          


Pro Glu Val Ser Arg Ser Ala His Val Pro Ser Leu Gln Arg Tyr Arg 
        35                  40                  45              


Glu Leu His Arg Arg Ser Val Glu Glu Pro Arg Glu Phe Trp Gly Asp 
    50                  55                  60                  


Ile Ala Lys Glu Phe Tyr Trp Lys Thr Pro Cys Pro Gly Pro Phe Leu 
65                  70                  75                  80  


Arg Tyr Asn Phe Asp Val Thr Lys Gly Lys Ile Phe Ile Glu Trp Met 
                85                  90                  95      


Lys Gly Ala Thr Thr Asn Ile Cys Tyr Asn Val Leu Asp Arg Asn Val 
            100                 105                 110         


His Glu Lys Lys Leu Gly Asp Lys Val Ala Phe Tyr Trp Glu Gly Asn 
        115                 120                 125             


Glu Pro Gly Glu Thr Thr Gln Ile Thr Tyr His Gln Leu Leu Val Gln 
    130                 135                 140                 


Val Cys Gln Phe Ser Asn Val Leu Arg Lys Gln Gly Ile Gln Lys Gly 
145                 150                 155                 160 


Asp Arg Val Ala Ile Tyr Met Pro Met Ile Pro Glu Leu Val Val Ala 
                165                 170                 175     


Met Leu Ala Cys Ala Arg Ile Gly Ala Leu His Ser Ile Val Phe Ala 
            180                 185                 190         


Gly Phe Ser Ser Glu Ser Leu Cys Glu Arg Ile Leu Asp Ser Ser Cys 
        195                 200                 205             


Ser Leu Leu Ile Thr Thr Asp Ala Phe Tyr Arg Gly Glu Lys Leu Val 
    210                 215                 220                 


Asn Leu Lys Glu Leu Ala Asp Glu Ala Leu Gln Lys Cys Gln Glu Lys 
225                 230                 235                 240 


Gly Phe Pro Val Arg Cys Cys Ile Val Val Lys His Leu Gly Arg Ala 
                245                 250                 255     


Glu Leu Gly Met Gly Asp Ser Thr Ser Gln Ser Pro Pro Ile Lys Arg 
            260                 265                 270         


Ser Cys Pro Asp Val Gln Ile Ser Trp Asn Gln Gly Ile Asp Leu Trp 
        275                 280                 285             


Trp His Glu Leu Met Gln Glu Ala Gly Asp Glu Cys Glu Pro Glu Trp 
    290                 295                 300                 


Cys Asp Ala Glu Asp Pro Leu Phe Ile Leu Tyr Thr Ser Gly Ser Thr 
305                 310                 315                 320 


Gly Lys Pro Lys Gly Val Val His Thr Val Gly Gly Tyr Met Leu Tyr 
                325                 330                 335     


Val Ala Thr Thr Phe Lys Tyr Val Phe Asp Phe His Ala Glu Asp Val 
            340                 345                 350         


Phe Trp Cys Thr Ala Asp Ile Gly Trp Ile Thr Gly His Ser Tyr Val 
        355                 360                 365             


Thr Tyr Gly Pro Leu Ala Asn Gly Ala Thr Ser Val Leu Phe Glu Gly 
    370                 375                 380                 


Ile Pro Thr Tyr Pro Asp Val Asn Arg Leu Trp Ser Ile Val Asp Lys 
385                 390                 395                 400 


Tyr Lys Val Thr Lys Phe Tyr Thr Ala Pro Thr Ala Ile Arg Leu Leu 
                405                 410                 415     


Met Lys Phe Gly Asp Glu Pro Val Thr Lys His Ser Arg Ala Ser Leu 
            420                 425                 430         


Gln Val Leu Gly Thr Val Gly Glu Pro Ile Asn Pro Glu Ala Trp Leu 
        435                 440                 445             


Trp Tyr His Arg Val Val Gly Ala Gln Arg Cys Pro Ile Val Asp Thr 
    450                 455                 460                 


Phe Trp Gln Thr Glu Thr Gly Gly His Met Leu Thr Pro Leu Pro Gly 
465                 470                 475                 480 


Ala Thr Pro Met Lys Pro Gly Ser Ala Thr Phe Pro Phe Phe Gly Val 
                485                 490                 495     


Ala Pro Ala Ile Leu Asn Glu Ser Gly Glu Glu Leu Glu Gly Glu Ala 
            500                 505                 510         


Glu Gly Tyr Leu Val Phe Lys Gln Pro Trp Pro Gly Ile Met Arg Thr 
        515                 520                 525             


Val Tyr Gly Asn His Glu Arg Phe Glu Thr Thr Tyr Phe Lys Lys Phe 
    530                 535                 540                 


Pro Gly Tyr Tyr Val Thr Gly Asp Gly Cys Gln Arg Asp Gln Asp Gly 
545                 550                 555                 560 


Tyr Tyr Trp Ile Thr Gly Arg Ile Asp Asp Met Leu Asn Val Ser Gly 
                565                 570                 575     


His Leu Leu Ser Thr Ala Glu Val Glu Ser Ala Leu Val Glu His Glu 
            580                 585                 590         


Ala Val Ala Glu Ala Ala Val Val Gly His Pro His Pro Val Lys Gly 
        595                 600                 605             


Glu Cys Leu Tyr Cys Phe Val Thr Leu Cys Asp Gly His Thr Phe Ser 
    610                 615                 620                 


Pro Lys Leu Thr Glu Glu Leu Lys Lys Gln Ile Arg Glu Lys Ile Gly 
625                 630                 635                 640 


Pro Ile Ala Thr Pro Asp Tyr Ile Gln Asn Ala Pro Gly Leu Pro Lys 
                645                 650                 655     


Thr Arg Ser Gly Lys Ile Met Arg Arg Val Leu Arg Lys Ile Ala Gln 
            660                 665                 670         


Asn Asp His Asp Leu Gly Asp Met Ser Thr Val Ala Asp Pro Ser Val 
        675                 680                 685             


Ile Ser His Leu Phe Ser His Arg Cys Leu Thr Ile Gln 
    690                 695                 700     


<210>  4485
<211>  1858
<212>  PRT
<213>  Homo sapiens

<400>  4485

Met Ser Ile Val Ile Pro Leu Gly Val Asp Thr Ala Glu Thr Ser Tyr 
1               5                   10                  15      


Leu Glu Met Ala Ala Gly Ser Glu Pro Glu Ser Val Glu Ala Ser Pro 
            20                  25                  30          


Val Val Val Glu Lys Ser Asn Ser Tyr Pro His Gln Leu Tyr Thr Ser 
        35                  40                  45              


Ser Ser His His Ser His Ser Tyr Ile Gly Leu Pro Tyr Ala Asp His 
    50                  55                  60                  


Asn Tyr Gly Ala Arg Pro Pro Pro Thr Pro Pro Ala Ser Pro Pro Pro 
65                  70                  75                  80  


Ser Val Leu Ile Ser Lys Asn Glu Val Gly Ile Phe Thr Thr Pro Asn 
                85                  90                  95      


Phe Asp Glu Thr Ser Ser Ala Thr Thr Ile Ser Thr Ser Glu Asp Gly 
            100                 105                 110         


Ser Tyr Gly Thr Asp Val Thr Arg Cys Ile Cys Gly Phe Thr His Asp 
        115                 120                 125             


Asp Gly Tyr Met Ile Cys Cys Asp Lys Cys Ser Val Trp Gln His Ile 
    130                 135                 140                 


Asp Cys Met Gly Ile Asp Arg Gln His Ile Pro Asp Thr Tyr Leu Cys 
145                 150                 155                 160 


Glu Arg Cys Gln Pro Arg Asn Leu Asp Lys Glu Arg Ala Val Leu Leu 
                165                 170                 175     


Gln Arg Arg Lys Arg Glu Asn Met Ser Asp Gly Asp Thr Ser Ala Thr 
            180                 185                 190         


Glu Ser Gly Asp Glu Val Pro Val Glu Leu Tyr Thr Ala Phe Gln His 
        195                 200                 205             


Thr Pro Thr Ser Ile Thr Leu Thr Ala Ser Arg Val Ser Lys Val Asn 
    210                 215                 220                 


Asp Lys Arg Arg Lys Lys Ser Gly Glu Lys Glu Gln His Ile Ser Lys 
225                 230                 235                 240 


Cys Lys Lys Ala Phe Arg Glu Gly Ser Arg Lys Ser Ser Arg Val Lys 
                245                 250                 255     


Gly Ser Ala Pro Glu Ile Asp Pro Ser Ser Asp Gly Ser Asn Phe Gly 
            260                 265                 270         


Trp Glu Thr Lys Ile Lys Ala Trp Met Asp Arg Tyr Glu Glu Ala Asn 
        275                 280                 285             


Asn Asn Gln Tyr Ser Glu Gly Val Gln Arg Glu Ala Gln Arg Ile Ala 
    290                 295                 300                 


Leu Arg Leu Gly Asn Gly Asn Asp Lys Lys Glu Met Asn Lys Ser Asp 
305                 310                 315                 320 


Leu Asn Thr Asn Asn Leu Leu Phe Lys Pro Pro Val Glu Ser His Ile 
                325                 330                 335     


Gln Lys Asn Lys Lys Ile Leu Lys Ser Ala Lys Asp Leu Pro Pro Asp 
            340                 345                 350         


Ala Leu Ile Ile Glu Tyr Arg Gly Lys Phe Met Leu Arg Glu Gln Phe 
        355                 360                 365             


Glu Ala Asn Gly Tyr Phe Phe Lys Arg Pro Tyr Pro Phe Val Leu Phe 
    370                 375                 380                 


Tyr Ser Lys Phe His Gly Leu Glu Met Cys Val Asp Ala Arg Thr Phe 
385                 390                 395                 400 


Gly Asn Glu Ala Arg Phe Ile Arg Arg Ser Cys Thr Pro Asn Ala Glu 
                405                 410                 415     


Val Arg His Glu Ile Gln Asp Gly Thr Ile His Leu Tyr Ile Tyr Ser 
            420                 425                 430         


Ile His Ser Ile Pro Lys Gly Thr Glu Ile Thr Ile Ala Phe Asp Phe 
        435                 440                 445             


Asp Tyr Gly Asn Cys Lys Tyr Lys Val Asp Cys Ala Cys Leu Lys Glu 
    450                 455                 460                 


Asn Pro Glu Cys Pro Val Leu Lys Arg Ser Ser Glu Ser Met Glu Asn 
465                 470                 475                 480 


Ile Asn Ser Gly Tyr Glu Thr Arg Arg Lys Lys Gly Lys Lys Asp Lys 
                485                 490                 495     


Asp Ile Ser Lys Glu Lys Asp Thr Gln Asn Gln Asn Ile Thr Leu Asp 
            500                 505                 510         


Cys Glu Gly Thr Thr Asn Lys Met Lys Ser Pro Glu Thr Lys Gln Arg 
        515                 520                 525             


Lys Leu Ser Pro Leu Arg Leu Ser Val Ser Asn Asn Gln Glu Pro Asp 
    530                 535                 540                 


Phe Ile Asp Asp Ile Glu Glu Lys Thr Pro Ile Ser Asn Glu Val Glu 
545                 550                 555                 560 


Met Glu Ser Glu Glu Gln Ile Ala Glu Arg Lys Arg Lys Met Thr Arg 
                565                 570                 575     


Glu Glu Arg Lys Met Glu Ala Ile Leu Gln Ala Phe Ala Arg Leu Glu 
            580                 585                 590         


Lys Arg Glu Lys Arg Arg Glu Gln Ala Leu Glu Arg Ile Ser Thr Ala 
        595                 600                 605             


Lys Thr Glu Val Lys Thr Glu Cys Lys Asp Thr Gln Ile Val Ser Asp 
    610                 615                 620                 


Ala Glu Val Ile Gln Glu Gln Ala Lys Glu Glu Asn Ala Ser Lys Pro 
625                 630                 635                 640 


Thr Pro Ala Lys Val Asn Arg Thr Lys Gln Arg Lys Ser Phe Ser Arg 
                645                 650                 655     


Ser Arg Thr His Ile Gly Gln Gln Arg Arg Arg His Arg Thr Val Ser 
            660                 665                 670         


Met Cys Ser Asp Ile Gln Pro Ser Ser Pro Asp Ile Glu Val Thr Ser 
        675                 680                 685             


Gln Gln Asn Asp Ile Glu Asn Thr Val Leu Thr Ile Glu Pro Glu Thr 
    690                 695                 700                 


Glu Thr Ala Leu Ala Glu Ile Ile Thr Glu Thr Glu Val Pro Ala Leu 
705                 710                 715                 720 


Asn Lys Cys Pro Thr Lys Tyr Pro Lys Thr Lys Lys His Leu Val Asn 
                725                 730                 735     


Glu Trp Leu Ser Glu Lys Asn Glu Lys Thr Gly Lys Pro Ser Asp Gly 
            740                 745                 750         


Leu Ser Glu Arg Pro Leu Arg Ile Thr Thr Asp Pro Glu Val Leu Ala 
        755                 760                 765             


Thr Gln Leu Asn Ser Leu Pro Gly Leu Thr Tyr Ser Pro His Val Tyr 
    770                 775                 780                 


Ser Thr Pro Lys His Tyr Ile Arg Phe Thr Ser Pro Phe Leu Ser Glu 
785                 790                 795                 800 


Lys Arg Arg Arg Lys Glu Pro Thr Glu Asn Ile Ser Gly Ser Cys Lys 
                805                 810                 815     


Lys Arg Trp Leu Lys Gln Ala Leu Glu Glu Glu Asn Ser Ala Ile Leu 
            820                 825                 830         


His Arg Phe Asn Ser Pro Cys Gln Glu Arg Ser Arg Ser Pro Ala Val 
        835                 840                 845             


Asn Gly Glu Asn Lys Ser Pro Leu Leu Leu Asn Asp Ser Cys Ser Leu 
    850                 855                 860                 


Pro Asp Leu Thr Thr Pro Leu Lys Lys Arg Arg Phe Tyr Gln Leu Leu 
865                 870                 875                 880 


Asp Ser Val Tyr Ser Glu Thr Ser Thr Pro Thr Pro Ser Pro Tyr Ala 
                885                 890                 895     


Thr Pro Thr His Thr Asp Ile Thr Pro Met Asp Pro Ser Phe Ala Thr 
            900                 905                 910         


Pro Pro Arg Ile Lys Ser Asp Asp Glu Thr Cys Arg Asn Gly Tyr Lys 
        915                 920                 925             


Pro Ile Tyr Ser Pro Val Thr Pro Val Thr Pro Gly Thr Pro Gly Asn 
    930                 935                 940                 


Thr Met His Phe Glu Asn Ile Ser Ser Pro Glu Ser Ser Pro Glu Ile 
945                 950                 955                 960 


Lys Arg Arg Thr Tyr Ser Gln Glu Gly Tyr Asp Arg Ser Ser Thr Met 
                965                 970                 975     


Leu Thr Leu Gly Pro Phe Arg Asn Ser Asn Leu Thr Glu Leu Gly Leu 
            980                 985                 990         


Gln Glu Ile Lys Thr Ile Gly Tyr  Thr Ser Pro Arg Ser  Arg Thr Glu 
        995                 1000                 1005             


Val Asn  Arg Gln Cys Pro Gly  Glu Lys Glu Pro Val  Ser Asp Leu 
    1010                 1015                 1020             


Gln Leu  Gly Leu Asp Ala Val  Glu Pro Thr Ala Leu  His Lys Thr 
    1025                 1030                 1035             


Leu Glu  Thr Pro Ala His Asp  Arg Ala Glu Pro Asn  Ser Gln Leu 
    1040                 1045                 1050             


Asp Ser  Thr His Ser Gly Arg  Gly Thr Met Tyr Ser  Ser Trp Val 
    1055                 1060                 1065             


Lys Ser  Pro Asp Arg Thr Gly  Val Asn Phe Ser Val  Asn Ser Asn 
    1070                 1075                 1080             


Leu Arg  Asp Leu Thr Pro Ser  His Gln Leu Glu Val  Gly Gly Gly 
    1085                 1090                 1095             


Phe Arg  Ile Ser Glu Ser Lys  Cys Leu Met Gln Asp  Asp Thr Arg 
    1100                 1105                 1110             


Gly Met  Phe Met Glu Thr Thr  Val Phe Cys Thr Ser  Glu Asp Gly 
    1115                 1120                 1125             


Leu Val  Ser Gly Phe Gly Arg  Thr Val Asn Asp Asn  Leu Ile Asp 
    1130                 1135                 1140             


Gly Asn  Cys Thr Pro Gln Asn  Pro Pro Gln Lys Lys  Lys Val Ser 
    1145                 1150                 1155             


Leu Leu  Glu Tyr Arg Lys Arg  Gln Arg Glu Ala Arg  Lys Ser Gly 
    1160                 1165                 1170             


Ser Lys  Thr Glu Asn Phe Pro  Leu Ile Ser Val Ser  Pro His Ala 
    1175                 1180                 1185             


Ser Gly  Ser Leu Ser Asn Asn  Gly Asp Gly Cys Ala  Ser Ser Asn 
    1190                 1195                 1200             


Asp Asn  Gly Glu Gln Val Asp  His Thr Ala Ser Leu  Pro Leu Pro 
    1205                 1210                 1215             


Thr Pro  Ala Thr Val Tyr Asn  Ala Thr Ser Glu Glu  Thr Ser Asn 
    1220                 1225                 1230             


Asn Cys  Pro Val Lys Asp Ala  Thr Ala Ser Glu Lys  Asn Glu Pro 
    1235                 1240                 1245             


Glu Val  Gln Trp Thr Ala Ser  Thr Ser Val Glu Gln  Val Arg Glu 
    1250                 1255                 1260             


Arg Ser  Tyr Gln Arg Ala Leu  Leu Leu Ser Asp His  Arg Lys Asp 
    1265                 1270                 1275             


Lys Asp  Ser Gly Gly Glu Ser  Pro Cys Val Ser Cys  Ser Pro Ser 
    1280                 1285                 1290             


His Val  Gln Ser Ser Pro Ser  Ser His Ser Asn His  Ile Pro Gln 
    1295                 1300                 1305             


Leu Gln  Ala Lys Gly Pro Val  Pro Ser Phe Ser Glu  Leu Met Glu 
    1310                 1315                 1320             


Asp Pro  Asp Pro Glu Asn Pro  Glu Pro Thr Thr Thr  Asn Glu Cys 
    1325                 1330                 1335             


Pro Ser  Pro Asp Thr Ser Gln  Asn Thr Cys Lys Ser  Pro Pro Lys 
    1340                 1345                 1350             


Met Ser  Lys Pro Gly Ser Pro  Gly Ser Val Ile Pro  Ala Gln Ala 
    1355                 1360                 1365             


His Gly  Lys Ile Phe Thr Lys  Pro Asp Pro Gln Trp  Asp Ser Thr 
    1370                 1375                 1380             


Val Ser  Ala Ser Glu Ala Glu  Asn Gly Val His Leu  Lys Thr Glu 
    1385                 1390                 1395             


Leu Gln  Gln Lys Gln Leu Ser  Asn Asn Asn Gln Ala  Leu Ser Lys 
    1400                 1405                 1410             


Asn His  Pro Pro Gln Thr His  Val Arg Asn Ser Ser  Glu Gln Leu 
    1415                 1420                 1425             


Ser Gln  Lys Leu Pro Ser Val  Pro Thr Lys Leu His  Cys Pro Pro 
    1430                 1435                 1440             


Ser Pro  His Leu Glu Asn Pro  Pro Lys Ser Ser Thr  Pro His Thr 
    1445                 1450                 1455             


Pro Val  Gln His Gly Tyr Leu  Ser Pro Lys Pro Pro  Ser Gln Gln 
    1460                 1465                 1470             


Leu Gly  Ser Pro Tyr Arg Pro  His His Ser Gln Ser  Pro Gln Val 
    1475                 1480                 1485             


Gly Thr  Pro Gln Arg Glu Pro  Gln Arg Asn Phe Tyr  Pro Ala Ala 
    1490                 1495                 1500             


Gln Asn  Leu Pro Ala Asn Thr  Gln Gln Ala Thr Ser  Gly Thr Leu 
    1505                 1510                 1515             


Phe Thr  Gln Thr Pro Ser Gly  Gln Ser Ser Ala Thr  Tyr Ser Gln 
    1520                 1525                 1530             


Phe Asn  Gln Gln Ser Leu Asn  Ser Thr Ala Pro Pro  Pro Pro Pro 
    1535                 1540                 1545             


Pro Pro  Pro Pro Ser Ser Ser  Tyr Tyr Gln Asn Gln  Gln Pro Ser 
    1550                 1555                 1560             


Ala Asn  Phe Gln Asn Tyr Asn  Gln Leu Lys Gly Ser  Leu Ser Gln 
    1565                 1570                 1575             


Gln Thr  Val Phe Thr Ser Gly  Pro Asn Gln Ala Leu  Pro Gly Thr 
    1580                 1585                 1590             


Thr Ser  Gln Gln Thr Val Pro  Gly His His Val Thr  Pro Gly His 
    1595                 1600                 1605             


Phe Leu  Pro Ser Gln Asn Pro  Thr Ile His His Gln  Thr Ala Ala 
    1610                 1615                 1620             


Ala Val  Val Pro Pro Pro Pro  Pro Pro Pro Pro Ala  Pro Gly Pro 
    1625                 1630                 1635             


His Leu  Val Gln Gln Pro Asn  Ser His Gln Gln His  Ser Val Ala 
    1640                 1645                 1650             


His Val  Val Gly Pro Val His  Ala Val Thr Pro Gly  Ser His Ile 
    1655                 1660                 1665             


His Ser  Gln Thr Ala Gly His  His Leu Pro Pro Pro  Pro Pro Pro 
    1670                 1675                 1680             


Pro Gly  Pro Ala Pro His His  His Pro Pro Pro His  Pro Ser Thr 
    1685                 1690                 1695             


Gly Leu  Gln Gly Leu Gln Ala  Gln His Gln His Val  Val Asn Ser 
    1700                 1705                 1710             


Ala Pro  Pro Pro Pro Pro Pro  Pro Pro Pro Ser Ser  Val Leu Ala 
    1715                 1720                 1725             


Ser Gly  His His Thr Thr Ser  Ala Gln Ala Leu His  His Pro Pro 
    1730                 1735                 1740             


His Gln  Gly Pro Pro Leu Phe  Pro Ser Ser Ala His  Pro Thr Val 
    1745                 1750                 1755             


Pro Pro  Tyr Pro Ser Gln Ala  Thr His His Thr Thr  Leu Gly Pro 
    1760                 1765                 1770             


Gly Pro  Gln His Gln Pro Ser  Gly Thr Gly Pro His  Cys Pro Leu 
    1775                 1780                 1785             


Pro Val  Thr Gly Pro His Leu  Gln Pro Gln Gly Pro  Asn Ser Ile 
    1790                 1795                 1800             


Pro Thr  Pro Thr Ala Ser Gly  Phe Cys Pro His Pro  Gly Ser Val 
    1805                 1810                 1815             


Ala Leu  Pro His Gly Val Gln  Gly Pro Gln Gln Ala  Ser Pro Val 
    1820                 1825                 1830             


Pro Gly  Gln Ile Pro Ile His  Arg Ala Gln Val Pro  Pro Thr Phe 
    1835                 1840                 1845             


Gln Asn  Asn Tyr His Gly Ser  Gly Trp His 
    1850                 1855             


<210>  4486
<211>  548
<212>  PRT
<213>  Homo sapiens

<400>  4486

Met Glu Glu Asp Leu Phe Gln Leu Arg Gln Leu Pro Val Val Lys Phe 
1               5                   10                  15      


Arg Arg Thr Gly Glu Ser Ala Arg Ser Glu Asp Asp Thr Ala Ser Gly 
            20                  25                  30          


Glu His Glu Val Gln Ile Glu Gly Val His Val Gly Leu Glu Ala Val 
        35                  40                  45              


Glu Leu Asp Asp Gly Ala Ala Val Pro Lys Glu Phe Ala Asn Pro Thr 
    50                  55                  60                  


Asp Asp Thr Phe Met Val Glu Asp Ala Val Glu Ala Ile Gly Phe Gly 
65                  70                  75                  80  


Lys Phe Gln Trp Lys Leu Ser Val Leu Thr Gly Leu Ala Trp Met Ala 
                85                  90                  95      


Asp Ala Met Glu Met Met Ile Leu Ser Ile Leu Ala Pro Gln Leu His 
            100                 105                 110         


Cys Glu Trp Arg Leu Pro Ser Trp Gln Val Ala Leu Leu Thr Ser Val 
        115                 120                 125             


Val Phe Val Gly Met Met Ser Ser Ser Thr Leu Trp Gly Asn Ile Ser 
    130                 135                 140                 


Asp Gln Tyr Gly Arg Lys Thr Gly Leu Lys Ile Ser Val Leu Trp Thr 
145                 150                 155                 160 


Leu Tyr Tyr Gly Ile Leu Ser Ala Phe Ala Pro Val Tyr Ser Trp Ile 
                165                 170                 175     


Leu Val Leu Arg Gly Leu Val Gly Phe Gly Ile Gly Gly Val Pro Gln 
            180                 185                 190         


Ser Val Thr Leu Tyr Ala Glu Phe Leu Pro Met Lys Ala Arg Ala Lys 
        195                 200                 205             


Cys Ile Leu Leu Ile Glu Val Phe Trp Ala Ile Gly Thr Val Phe Glu 
    210                 215                 220                 


Val Val Leu Ala Val Phe Val Met Pro Ser Leu Gly Trp Arg Trp Leu 
225                 230                 235                 240 


Leu Ile Leu Ser Ala Val Pro Leu Leu Leu Phe Ala Val Leu Cys Phe 
                245                 250                 255     


Trp Leu Pro Glu Ser Ala Arg Tyr Asp Val Leu Ser Gly Asn Gln Glu 
            260                 265                 270         


Lys Ala Ile Ala Thr Leu Lys Arg Ile Ala Thr Glu Asn Gly Ala Pro 
        275                 280                 285             


Met Pro Leu Gly Lys Leu Ile Ile Ser Arg Gln Glu Asp Arg Gly Lys 
    290                 295                 300                 


Met Arg Asp Leu Phe Thr Pro His Phe Arg Trp Thr Thr Leu Leu Leu 
305                 310                 315                 320 


Trp Phe Ile Trp Phe Ser Asn Ala Phe Ser Tyr Tyr Gly Leu Val Leu 
                325                 330                 335     


Leu Thr Thr Glu Leu Phe Gln Ala Gly Asp Val Cys Gly Ile Ser Ser 
            340                 345                 350         


Arg Lys Lys Ala Val Glu Ala Lys Cys Ser Leu Ala Cys Glu Tyr Leu 
        355                 360                 365             


Ser Glu Glu Asp Tyr Met Asp Leu Leu Trp Thr Thr Leu Ser Glu Phe 
    370                 375                 380                 


Pro Gly Val Leu Val Thr Leu Trp Ile Ile Asp Arg Leu Gly Arg Lys 
385                 390                 395                 400 


Lys Thr Met Ala Leu Cys Phe Val Ile Phe Ser Phe Cys Ser Leu Leu 
                405                 410                 415     


Leu Phe Ile Cys Val Gly Arg Asn Val Leu Thr Leu Leu Leu Phe Ile 
            420                 425                 430         


Ala Arg Ala Phe Ile Ser Gly Gly Phe Gln Ala Ala Tyr Val Tyr Thr 
        435                 440                 445             


Pro Glu Val Tyr Pro Thr Ala Thr Arg Ala Leu Gly Leu Gly Thr Cys 
    450                 455                 460                 


Ser Gly Met Ala Arg Val Gly Ala Leu Ile Thr Pro Phe Ile Ala Gln 
465                 470                 475                 480 


Val Met Leu Glu Ser Ser Val Tyr Leu Thr Leu Ala Val Tyr Ser Gly 
                485                 490                 495     


Cys Cys Leu Leu Ala Ala Leu Ala Ser Cys Phe Leu Pro Ile Glu Thr 
            500                 505                 510         


Lys Gly Arg Gly Leu Gln Glu Ser Ser His Arg Glu Trp Gly Gln Glu 
        515                 520                 525             


Met Val Gly Arg Gly Met His Gly Ala Gly Val Thr Arg Ser Asn Ser 
    530                 535                 540                 


Gly Ser Gln Glu 
545             


<210>  4487
<211>  485
<212>  PRT
<213>  Homo sapiens

<400>  4487

Met Gly Arg Tyr Ser Gly Lys Thr Cys Arg Leu Leu Phe Met Leu Val 
1               5                   10                  15      


Leu Thr Val Ala Phe Phe Val Ala Glu Leu Val Ser Gly Tyr Leu Gly 
            20                  25                  30          


Asn Ser Ile Ala Leu Leu Ser Asp Ser Phe Asn Met Leu Ser Asp Leu 
        35                  40                  45              


Ile Ser Leu Cys Val Gly Leu Ser Ala Gly Tyr Ile Ala Arg Arg Pro 
    50                  55                  60                  


Thr Arg Gly Phe Ser Ala Thr Tyr Gly Tyr Ala Arg Ala Glu Val Val 
65                  70                  75                  80  


Gly Ala Leu Ser Asn Ala Val Phe Leu Thr Ala Leu Cys Phe Thr Ile 
                85                  90                  95      


Phe Val Glu Ala Val Leu Arg Leu Ala Arg Pro Glu Arg Ile Asp Asp 
            100                 105                 110         


Pro Glu Leu Val Leu Ile Val Gly Val Leu Gly Leu Leu Val Asn Val 
        115                 120                 125             


Val Gly Leu Leu Ile Phe Gln Asp Cys Ala Ala Trp Phe Ala Cys Cys 
    130                 135                 140                 


Leu Arg Gly Arg Ser Arg Arg Leu Gln Gln Arg Gln Gln Leu Ala Glu 
145                 150                 155                 160 


Gly Cys Val Pro Gly Ala Phe Gly Gly Pro Gln Gly Ala Glu Asp Pro 
                165                 170                 175     


Arg Arg Ala Ala Asp Pro Thr Ala Pro Gly Ser Asp Ser Ala Val Thr 
            180                 185                 190         


Leu Arg Gly Thr Ser Val Glu Arg Lys Arg Glu Lys Gly Ala Thr Val 
        195                 200                 205             


Phe Ala Asn Val Ala Gly Asp Ser Phe Asn Thr Gln Asn Glu Pro Glu 
    210                 215                 220                 


Asp Met Met Lys Lys Glu Lys Lys Ser Glu Ala Leu Asn Ile Arg Gly 
225                 230                 235                 240 


Val Leu Leu His Val Met Gly Asp Ala Leu Gly Ser Val Val Val Val 
                245                 250                 255     


Ile Thr Ala Ile Ile Phe Tyr Val Leu Pro Leu Lys Ser Glu Asp Pro 
            260                 265                 270         


Cys Asn Trp Gln Cys Tyr Ile Asp Pro Ser Leu Thr Val Leu Met Val 
        275                 280                 285             


Ile Ile Ile Leu Ser Ser Ala Phe Pro Leu Ile Lys Glu Thr Ala Ala 
    290                 295                 300                 


Ile Leu Leu Gln Met Val Pro Lys Gly Val Asn Met Glu Glu Leu Met 
305                 310                 315                 320 


Ser Lys Leu Ser Ala Val Pro Gly Ile Ser Ser Val His Glu Val His 
                325                 330                 335     


Ile Trp Glu Leu Val Ser Gly Lys Ile Ile Ala Thr Leu His Ile Lys 
            340                 345                 350         


Tyr Pro Lys Asp Arg Gly Tyr Gln Asp Ala Ser Thr Lys Ile Arg Glu 
        355                 360                 365             


Ile Phe His His Ala Gly Ile His Asn Val Thr Ile Gln Phe Glu Asn 
    370                 375                 380                 


Val Asp Leu Lys Glu Pro Leu Glu Gln Lys Asp Leu Leu Leu Leu Cys 
385                 390                 395                 400 


Asn Ser Pro Cys Ile Ser Lys Gly Cys Ala Lys Gln Leu Cys Cys Pro 
                405                 410                 415     


Pro Gly Ala Leu Pro Leu Ala His Val Asn Gly Cys Ala Glu His Asn 
            420                 425                 430         


Gly Gly Pro Ser Leu Asp Thr Tyr Gly Ser Asp Gly Leu Ser Arg Arg 
        435                 440                 445             


Asp Ala Arg Glu Val Ala Ile Glu Val Ser Leu Asp Ser Cys Leu Ser 
    450                 455                 460                 


Asp His Gly Gln Ser Leu Asn Lys Thr Gln Glu Asp Gln Cys Tyr Val 
465                 470                 475                 480 


Asn Arg Thr His Phe 
                485 


<210>  4488
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  4488

Met Glu Leu Ala Thr Arg Tyr Gln Ile Pro Lys Glu Val Ala Asp Ile 
1               5                   10                  15      


Phe Asn Ala Pro Ser Asp Asp Glu Glu Phe Val Gly Phe Arg Asp Asp 
            20                  25                  30          


Val Pro Met Glu Thr Leu Ser Ser Glu Glu Ser Cys Asp Ser Phe Asp 
        35                  40                  45              


Ser Leu Glu Ser Gly Lys Gln Gln Asp Val Arg Phe His Ser Lys Tyr 
    50                  55                  60                  


Phe Thr Glu Glu Leu Arg Arg Ile Phe Ile Glu Asp Thr Asp Ser Glu 
65                  70                  75                  80  


Thr Glu Asp Phe Ala Gly Phe Thr Gln Ser Asp Leu Asn Gly Lys Thr 
                85                  90                  95      


Asn Pro Glu Val Met Val Val Glu Ser Asp Leu Ser Asp Asp Gly Lys 
            100                 105                 110         


Ala Ser Leu Val Ser Glu Glu Glu Glu Asp Glu Glu Glu Asp Lys Ala 
        115                 120                 125             


Thr Pro Arg Arg Ser Arg Ser Arg Arg Ser Ser Ile Gly Leu Arg Val 
    130                 135                 140                 


Ala Phe Gln Phe Pro Thr Lys Lys Leu Ala Asn Lys Pro Asp Lys Asn 
145                 150                 155                 160 


Ser Ser Ser Glu Gln Leu Phe Ser Ser Ala Arg Leu Gln Asn Glu Lys 
                165                 170                 175     


Lys Thr Ile Leu Glu Arg Lys Lys Asp Cys Arg Gln Val Ile Gln Arg 
            180                 185                 190         


Glu Asp Ser Thr Ser Glu Ser Glu Asp Asp Ser Arg Asp Glu Ser Gln 
        195                 200                 205             


Glu Ser Ser Asp Ala Leu Leu Lys Arg Thr Met Asn Ile Lys Glu Asn 
    210                 215                 220                 


Lys Ala Met Leu Ala Gln Leu Leu Ala Glu Leu Asn Ser Met Pro Asp 
225                 230                 235                 240 


Phe Phe Pro Val Arg Thr Pro Thr Ser Ala Ser Arg Lys Lys Thr Val 
                245                 250                 255     


Arg Arg Ala Phe Ser Glu Gly Gln Ile Thr Arg Arg Met Asn Pro Thr 
            260                 265                 270         


Arg Ser Ala Arg Pro Pro Glu Lys Phe Ala Leu Glu Asn Phe Thr Val 
        275                 280                 285             


Ser Ala Ala Lys Phe Ala Glu Glu Phe Tyr Ser Phe Arg Arg Arg Lys 
    290                 295                 300                 


Thr Ile Gly Gly Lys Cys Arg Glu Tyr Arg Arg Arg His Arg Ile Ser 
305                 310                 315                 320 


Ser Phe Arg Pro Val Glu Asp Ile Thr Glu Glu Asp Leu Glu Asn Val 
                325                 330                 335     


Ala Ile Thr Val Arg Asp Lys Ile Tyr Asp Lys Val Leu Gly Asn Thr 
            340                 345                 350         


Cys His Gln Cys Arg Gln Lys Thr Ile Asp Thr Lys Thr Val Cys Arg 
        355                 360                 365             


Asn Gln Gly Cys Cys Gly Val Arg Gly Gln Phe Cys Gly Pro Cys Leu 
    370                 375                 380                 


Arg Asn Arg Tyr Gly Glu Asp Val Arg Ser Ala Leu Leu Asp Pro Asp 
385                 390                 395                 400 


Trp Val Cys Pro Pro Cys Arg Gly Ile Cys Asn Cys Ser Tyr Cys Arg 
                405                 410                 415     


Lys Arg Asp Gly Arg Cys Ala Thr Gly Ile Leu Ile His Leu Ala Lys 
            420                 425                 430         


Phe Tyr Gly Tyr Asp Asn Val Lys Glu Tyr Leu Glu Ser Leu Gln Lys 
        435                 440                 445             


Glu Leu Val Glu Asp Asn 
    450                 


<210>  4489
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  4489

Met Ser Leu Val Leu Leu Ser Leu Ala Ala Leu Cys Arg Ser Ala Val 
1               5                   10                  15      


Pro Arg Glu Pro Thr Val Gln Cys Gly Ser Glu Thr Gly Pro Ser Pro 
            20                  25                  30          


Glu Trp Met Leu Gln His Asp Leu Ile Pro Gly Asp Leu Arg Asp Leu 
        35                  40                  45              


Arg Val Glu Pro Val Thr Thr Ser Val Ala Thr Gly Asp Tyr Ser Ile 
    50                  55                  60                  


Leu Met Asn Val Ser Trp Val Leu Arg Ala Asp Ala Ser Ile Arg Leu 
65                  70                  75                  80  


Leu Lys Ala Thr Lys Ile Cys Val Thr Gly Lys Ser Asn Phe Gln Ser 
                85                  90                  95      


Tyr Ser Cys Val Arg Cys Asn Tyr Thr Glu Ala Phe Gln Thr Gln Thr 
            100                 105                 110         


Arg Pro Ser Gly Gly Lys Trp Thr Phe Ser Tyr Ile Gly Phe Pro Val 
        115                 120                 125             


Glu Leu Asn Thr Val Tyr Phe Ile Gly Ala His Asn Ile Pro Asn Ala 
    130                 135                 140                 


Asn Met Asn Glu Asp Gly Pro Ser Met Ser Val Asn Phe Thr Ser Pro 
145                 150                 155                 160 


Gly Cys Leu Asp His Ile Met Lys Tyr Lys Lys Lys Cys Val Lys Ala 
                165                 170                 175     


Gly Ser Leu Trp Asp Pro Asn Ile Thr Ala Cys Lys Lys Asn Glu Glu 
            180                 185                 190         


Thr Val Glu Val Asn Phe Thr Thr Thr Pro Leu Gly Asn Arg Tyr Met 
        195                 200                 205             


Ala Leu Ile Gln His Ser Thr Ile Ile Gly Phe Ser Gln Val Phe Glu 
    210                 215                 220                 


Pro His Gln Lys Lys Gln Thr Arg Ala Ser Val Val Ile Pro Val Thr 
225                 230                 235                 240 


Gly Asp Ser Glu Gly Ala Thr Val Gln Leu Thr Pro Tyr Phe Pro Thr 
                245                 250                 255     


Cys Gly Ser Asp Cys Ile Arg His Lys Gly Thr Val Val Leu Cys Pro 
            260                 265                 270         


Gln Thr Gly Val Pro Phe Pro Leu Asp Asn Asn Lys Ser Lys Pro Gly 
        275                 280                 285             


Gly Trp Leu Pro Leu Leu Leu Leu Ser Leu Leu Val Ala Thr Trp Val 
    290                 295                 300                 


Leu Val Ala Gly Ile Tyr Leu Met Trp Arg His Glu Arg Ile Lys Lys 
305                 310                 315                 320 


Thr Ser Phe Ser Thr Thr Thr Leu Leu Pro Pro Ile Lys Val Leu Val 
                325                 330                 335     


Val Tyr Pro Ser Glu Ile Cys Phe His His Thr Ile Cys Tyr Phe Thr 
            340                 345                 350         


Glu Phe Leu Gln Asn His Cys Arg Ser Glu Val Ile Leu Glu Lys Trp 
        355                 360                 365             


Gln Lys Lys Lys Ile Ala Glu Met Gly Pro Val Gln Trp Leu Ala Thr 
    370                 375                 380                 


Gln Lys Lys Ala Ala Asp Lys Val Val Phe Leu Leu Ser Asn Asp Val 
385                 390                 395                 400 


Asn Ser Val Cys Asp Gly Thr Cys Gly Lys Ser Glu Gly Ser Pro Ser 
                405                 410                 415     


Glu Asn Ser Gln Asp Leu Phe Pro Leu Ala Phe Asn Leu Phe Cys Ser 
            420                 425                 430         


Asp Leu Arg Ser Gln Ile His Leu His Lys Tyr Val Val Val Tyr Phe 
        435                 440                 445             


Arg Glu Ile Asp Thr Lys Asp Asp Tyr Asn Ala Leu Ser Val Cys Pro 
    450                 455                 460                 


Lys Tyr His Leu Met Lys Asp Ala Thr Ala Phe Cys Ala Glu Leu Leu 
465                 470                 475                 480 


His Val Lys Gln Gln Val Ser Ala Gly Lys Arg Ser Gln Ala Cys His 
                485                 490                 495     


Asp Gly Cys Cys Ser Leu 
            500         


<210>  4490
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  4490

Met Lys Lys Trp Ser Ser Thr Asp Leu Gly Ala Ala Ala Asp Pro Leu 
1               5                   10                  15      


Gln Lys Asp Thr Cys Pro Asp Pro Leu Asp Gly Asp Pro Asn Ser Arg 
            20                  25                  30          


Pro Pro Pro Ala Lys Pro Gln Leu Ser Thr Ala Lys Ser Arg Thr Arg 
        35                  40                  45              


Leu Phe Gly Lys Gly Asp Ser Glu Glu Ala Phe Pro Val Asp Cys Pro 
    50                  55                  60                  


His Glu Glu Gly Glu Leu Asp Ser Cys Pro Thr Ile Thr Val Ser Pro 
65                  70                  75                  80  


Val Ile Thr Ile Gln Arg Pro Gly Asp Gly Pro Thr Gly Ala Arg Leu 
                85                  90                  95      


Leu Ser Gln Asp Ser Val Ala Ala Ser Thr Glu Lys Thr Leu Arg Leu 
            100                 105                 110         


Tyr Asp Arg Arg Ser Ile Phe Glu Ala Val Ala Gln Asn Asn Cys Gln 
        115                 120                 125             


Asp Leu Glu Ser Leu Leu Leu Phe Leu Gln Lys Ser Lys Lys His Leu 
    130                 135                 140                 


Thr Asp Asn Glu Phe Lys Asp Pro Glu Thr Gly Lys Thr Cys Leu Leu 
145                 150                 155                 160 


Lys Ala Met Leu Asn Leu His Asp Gly Gln Asn Thr Thr Ile Pro Leu 
                165                 170                 175     


Leu Leu Glu Ile Ala Arg Gln Thr Asp Ser Leu Lys Glu Leu Val Asn 
            180                 185                 190         


Ala Ser Tyr Thr Asp Ser Tyr Tyr Lys Gly Gln Thr Ala Leu His Ile 
        195                 200                 205             


Ala Ile Glu Arg Arg Asn Met Ala Leu Val Thr Leu Leu Val Glu Asn 
    210                 215                 220                 


Gly Ala Asp Val Gln Ala Ala Ala His Gly Asp Phe Phe Lys Lys Thr 
225                 230                 235                 240 


Lys Gly Arg Pro Gly Phe Tyr Phe Gly Glu Leu Pro Leu Ser Leu Ala 
                245                 250                 255     


Ala Cys Thr Asn Gln Leu Gly Ile Val Lys Phe Leu Leu Gln Asn Ser 
            260                 265                 270         


Trp Gln Thr Ala Asp Ile Ser Ala Arg Asp Ser Val Gly Asn Thr Val 
        275                 280                 285             


Leu His Ala Leu Val Glu Val Ala Asp Asn Thr Ala Asp Asn Thr Lys 
    290                 295                 300                 


Phe Val Thr Ser Met Tyr Asn Glu Ile Leu Met Leu Gly Ala Lys Leu 
305                 310                 315                 320 


His Pro Thr Leu Lys Leu Glu Glu Leu Thr Asn Lys Lys Gly Met Thr 
                325                 330                 335     


Pro Leu Ala Leu Ala Ala Gly Thr Gly Lys Ile Gly Val Leu Ala Tyr 
            340                 345                 350         


Ile Leu Gln Arg Glu Ile Gln Glu Pro Glu Cys Arg His Leu Ser Arg 
        355                 360                 365             


Lys Phe Thr Glu Trp Ala Tyr Gly Pro Val His Ser Ser Leu Tyr Asp 
    370                 375                 380                 


Leu Ser Cys Ile Asp Thr Cys Glu Lys Asn Ser Val Leu Glu Val Ile 
385                 390                 395                 400 


Ala Tyr Ser Ser Ser Glu Thr Pro Asn Arg His Asp Met Leu Leu Val 
                405                 410                 415     


Glu Pro Leu Asn Arg Leu Leu Gln Asp Lys Trp Asp Arg Phe Val Lys 
            420                 425                 430         


Arg Ile Phe Tyr Phe Asn Phe Leu Val Tyr Cys Leu Tyr Met Ile Ile 
        435                 440                 445             


Phe Thr Met Ala Ala Tyr Tyr Arg Pro Val Asp Gly Leu Pro Pro Phe 
    450                 455                 460                 


Lys Met Glu Lys Thr Gly Asp Tyr Phe Arg Val Thr Gly Glu Ile Leu 
465                 470                 475                 480 


Ser Val Leu Gly Gly Val Tyr Phe Phe Phe Arg Gly Ile Gln Tyr Phe 
                485                 490                 495     


Leu Gln Arg Arg Pro Ser Met Lys Thr Leu Phe Val Asp Ser Tyr Ser 
            500                 505                 510         


Glu Met Leu Phe Phe Leu Gln Ser Leu Phe Met Leu Ala Thr Val Val 
        515                 520                 525             


Leu Tyr Phe Ser His Leu Lys Glu Tyr Val Ala Ser Met Val Phe Ser 
    530                 535                 540                 


Leu Ala Leu Gly Trp Thr Asn Met Leu Tyr Tyr Thr Arg Gly Phe Gln 
545                 550                 555                 560 


Gln Met Gly Ile Tyr Ala Val Met Ile Glu Lys Met Ile Leu Arg Asp 
                565                 570                 575     


Leu Cys Arg Phe Met Phe Val Tyr Ile Val Phe Leu Phe Gly Phe Ser 
            580                 585                 590         


Thr Ala Val Val Thr Leu Ile Glu Asp Gly Lys Asn Asp Ser Leu Pro 
        595                 600                 605             


Ser Glu Ser Thr Ser His Arg Trp Arg Gly Pro Ala Cys Arg Pro Pro 
    610                 615                 620                 


Asp Ser Ser Tyr Asn Ser Leu Tyr Ser Thr Cys Leu Glu Leu Phe Lys 
625                 630                 635                 640 


Phe Thr Ile Gly Met Gly Asp Leu Glu Phe Thr Glu Asn Tyr Asp Phe 
                645                 650                 655     


Lys Ala Val Phe Ile Ile Leu Leu Leu Ala Tyr Val Ile Leu Thr Tyr 
            660                 665                 670         


Ile Leu Leu Leu Asn Met Leu Ile Ala Leu Met Gly Glu Thr Val Asn 
        675                 680                 685             


Lys Ile Ala Gln Glu Ser Lys Asn Ile Trp Lys Leu Gln Arg Ala Ile 
    690                 695                 700                 


Thr Ile Leu Asp Thr Glu Lys Ser Phe Leu Lys Cys Met Arg Lys Ala 
705                 710                 715                 720 


Phe Arg Ser Gly Lys Leu Leu Gln Val Gly Tyr Thr Pro Asp Gly Lys 
                725                 730                 735     


Asp Asp Tyr Arg Trp Cys Phe Arg Val Asp Glu Val Asn Trp Thr Thr 
            740                 745                 750         


Trp Asn Thr Asn Val Gly Ile Ile Asn Glu Asp Pro Gly Asn Cys Glu 
        755                 760                 765             


Gly Val Lys Arg Thr Leu Ser Phe Ser Leu Arg Ser Ser Arg Val Ser 
    770                 775                 780                 


Gly Arg His Trp Lys Asn Phe Ala Leu Val Pro Leu Leu Arg Glu Ala 
785                 790                 795                 800 


Ser Ala Arg Asp Arg Gln Ser Ala Gln Pro Glu Glu Val Tyr Leu Arg 
                805                 810                 815     


Gln Phe Ser Gly Ser Leu Lys Pro Glu Asp Ala Glu Val Phe Lys Ser 
            820                 825                 830         


Pro Ala Ala Ser Gly Glu Lys 
        835                 


<210>  4491
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  4491

Met Trp Ile Gln Gln Leu Leu Gly Leu Ser Ser Met Ser Ile Arg Trp 
1               5                   10                  15      


Pro Gly Arg Pro Leu Gly Ser His Ala Trp Ile Leu Ile Ala Met Phe 
            20                  25                  30          


Gln Leu Ala Val Asp Leu Pro Ala Cys Glu Ala Leu Gly Pro Gly Pro 
        35                  40                  45              


Glu Phe Trp Leu Leu Pro Arg Ser Pro Pro Arg Pro Pro Arg Leu Trp 
    50                  55                  60                  


Ser Phe Arg Ser Gly Gln Pro Ala Arg Val Pro Ala Pro Val Trp Ser 
65                  70                  75                  80  


Pro Arg Pro Pro Arg Val Glu Arg Ile His Gly Gln Met Gln Met Pro 
                85                  90                  95      


Arg Ala Arg Arg Ala His Arg Pro Arg Asp Gln Ala Ala Ala Leu Val 
            100                 105                 110         


Pro Lys Ala Gly Leu Ala Lys Pro Pro Ala Ala Ala Lys Ser Ser Pro 
        115                 120                 125             


Ser Leu Ala Ser Ser Ser Ser Ser Ser Ser Ser Ala Val Ala Gly Gly 
    130                 135                 140                 


Ala Pro Glu Gln Gln Ala Leu Leu Arg Arg Gly Lys Arg His Leu Gln 
145                 150                 155                 160 


Gly Asp Gly Leu Ser Ser Phe Asp Ser Arg Gly Ser Arg Pro Thr Thr 
                165                 170                 175     


Glu Thr Glu Phe Ile Ala Trp Gly Pro Thr Gly Asp Glu Glu Ala Leu 
            180                 185                 190         


Glu Ser Asn Thr Phe Pro Gly Val Tyr Gly Pro Thr Thr Val Ser Ile 
        195                 200                 205             


Leu Gln Thr Arg Lys Thr Thr Val Ala Ala Thr Thr Thr Thr Thr Thr 
    210                 215                 220                 


Thr Ala Thr Pro Met Thr Leu Gln Thr Lys Gly Phe Thr Glu Ser Leu 
225                 230                 235                 240 


Asp Pro Arg Arg Arg Ile Pro Gly Gly Val Ser Thr Thr Glu Pro Ser 
                245                 250                 255     


Thr Ser Pro Ser Asn Asn Gly Glu Val Thr Gln Pro Pro Arg Ile Leu 
            260                 265                 270         


Gly Glu Ala Ser Gly Leu Ala Val His Gln Ile Ile Thr Ile Thr Val 
        275                 280                 285             


Ser Leu Ile Met Val Ile Ala Ala Leu Ile Thr Thr Leu Val Leu Lys 
    290                 295                 300                 


Asn Cys Cys Ala Gln Ser Gly Asn Thr Arg Arg Asn Ser His Gln Arg 
305                 310                 315                 320 


Lys Thr Asn Gln Gln Glu Glu Ser Cys Gln Asn Leu Thr Asp Phe Pro 
                325                 330                 335     


Ser Ala Arg Val Pro Ser Ser Leu Asp Ile Phe Thr Ala Tyr Asn Glu 
            340                 345                 350         


Thr Leu Gln Cys Ser His Glu Cys Val Arg Ala Ser Val Pro Val Tyr 
        355                 360                 365             


Thr Asp Glu Thr Leu His Ser Thr Thr Gly Glu Tyr Lys Ser Thr Phe 
    370                 375                 380                 


Asn Gly Asn Arg Pro Ser Ser Ser Asp Arg His Leu Ile Pro Val Ala 
385                 390                 395                 400 


Phe Val Ser Glu Lys Trp Phe Glu Ile Ser Cys 
                405                 410     


<210>  4492
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  4492

Met Thr Leu Gln Trp Ala Ala Val Ala Thr Phe Leu Tyr Ala Glu Ile 
1               5                   10                  15      


Gly Leu Ile Leu Ile Phe Cys Leu Pro Phe Ile Pro Pro Gln Arg Trp 
            20                  25                  30          


Gln Lys Ile Phe Ser Phe Asn Val Trp Gly Lys Ile Ala Thr Phe Trp 
        35                  40                  45              


Asn Lys Ala Phe Leu Thr Ile Ile Ile Leu Leu Ile Val Leu Phe Leu 
    50                  55                  60                  


Asp Ala Val Arg Glu Val Arg Lys Tyr Ser Ser Val His Thr Ile Glu 
65                  70                  75                  80  


Lys Ser Ser Thr Ser Arg Pro Asp Ala Tyr Glu His Thr Gln Met Lys 
                85                  90                  95      


Leu Phe Arg Ser Gln Arg Asn Leu Tyr Ile Ser Gly Phe Ser Leu Phe 
            100                 105                 110         


Phe Trp Leu Val Leu Arg Arg Leu Val Thr Leu Ile Thr Gln Leu Ala 
        115                 120                 125             


Lys Glu Leu Ser Asn Lys Gly Val Leu Lys Thr Gln Ala Glu Asn Thr 
    130                 135                 140                 


Asn Lys Ala Ala Lys Lys Phe Met Glu Glu Asn Glu Lys Leu Lys Arg 
145                 150                 155                 160 


Ile Leu Lys Ser His Gly Lys Asp Glu Glu Cys Val Leu Glu Ala Glu 
                165                 170                 175     


Asn Lys Lys Leu Val Glu Asp Gln Glu Lys Leu Lys Thr Glu Leu Arg 
            180                 185                 190         


Lys Thr Ser Asp Ala Leu Ser Lys Ala Gln Asn Asp Val Met Glu Met 
        195                 200                 205             


Lys Met Gln Ser Glu Arg Leu Ser Lys Glu Tyr Asp Gln Leu Leu Lys 
    210                 215                 220                 


Glu His Ser Glu Leu Gln Asp Arg Leu Glu Arg Gly Asn Lys Lys Arg 
225                 230                 235                 240 


Leu 
    


<210>  4493
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  4493

Met Glu Ala Gly Gly Phe Leu Asp Ser Leu Ile Tyr Gly Ala Cys Val 
1               5                   10                  15      


Val Phe Thr Leu Gly Met Phe Ser Ala Gly Leu Ser Asp Leu Arg His 
            20                  25                  30          


Met Arg Met Thr Arg Ser Val Asp Asn Val Gln Phe Leu Pro Phe Leu 
        35                  40                  45              


Thr Thr Glu Val Asn Asn Leu Gly Trp Leu Ser Tyr Gly Ala Leu Lys 
    50                  55                  60                  


Gly Asp Gly Ile Leu Ile Val Val Asn Thr Val Gly Ala Ala Leu Gln 
65                  70                  75                  80  


Thr Leu Tyr Ile Leu Ala Tyr Leu His Tyr Cys Pro Arg Lys Arg Val 
                85                  90                  95      


Val Leu Leu Gln Thr Ala Thr Leu Leu Gly Val Leu Leu Leu Gly Tyr 
            100                 105                 110         


Gly Tyr Phe Trp Leu Leu Val Pro Asn Pro Glu Ala Arg Leu Gln Gln 
        115                 120                 125             


Leu Gly Leu Phe Cys Ser Val Phe Thr Ile Ser Met Tyr Leu Ser Pro 
    130                 135                 140                 


Leu Ala Asp Leu Ala Lys Val Ile Gln Thr Lys Ser Thr Gln Cys Leu 
145                 150                 155                 160 


Ser Tyr Pro Leu Thr Ile Ala Thr Leu Leu Thr Ser Ala Ser Trp Cys 
                165                 170                 175     


Leu Tyr Gly Phe Arg Leu Arg Asp Pro Tyr Ile Met Val Ser Asn Phe 
            180                 185                 190         


Pro Gly Ile Val Thr Ser Phe Ile Arg Phe Trp Leu Phe Trp Lys Tyr 
        195                 200                 205             


Pro Gln Glu Gln Asp Arg Asn Tyr Trp Leu Leu Gln Thr 
    210                 215                 220     


<210>  4494
<211>  1286
<212>  PRT
<213>  Homo sapiens

<400>  4494

Met Asp Leu Glu Ala Ala Lys Asn Gly Thr Ala Trp Arg Pro Thr Ser 
1               5                   10                  15      


Ala Glu Gly Asp Phe Glu Leu Gly Ile Ser Ser Lys Gln Lys Arg Lys 
            20                  25                  30          


Lys Thr Lys Thr Val Lys Met Ile Gly Val Leu Thr Leu Phe Arg Tyr 
        35                  40                  45              


Ser Asp Trp Gln Asp Lys Leu Phe Met Ser Leu Gly Thr Ile Met Ala 
    50                  55                  60                  


Ile Ala His Gly Ser Gly Leu Pro Leu Met Met Ile Val Phe Gly Glu 
65                  70                  75                  80  


Met Thr Asp Lys Phe Val Asp Thr Ala Gly Asn Phe Ser Phe Pro Val 
                85                  90                  95      


Asn Phe Ser Leu Ser Leu Leu Asn Pro Gly Lys Ile Leu Glu Glu Glu 
            100                 105                 110         


Met Thr Arg Tyr Ala Tyr Tyr Tyr Ser Gly Leu Gly Ala Gly Val Leu 
        115                 120                 125             


Val Ala Ala Tyr Ile Gln Val Ser Phe Trp Thr Leu Ala Ala Gly Arg 
    130                 135                 140                 


Gln Ile Arg Lys Ile Arg Gln Lys Phe Phe His Ala Ile Leu Arg Gln 
145                 150                 155                 160 


Glu Ile Gly Trp Phe Asp Ile Asn Asp Thr Thr Glu Leu Asn Thr Arg 
                165                 170                 175     


Leu Thr Asp Asp Ile Ser Lys Ile Ser Glu Gly Ile Gly Asp Lys Val 
            180                 185                 190         


Gly Met Phe Phe Gln Ala Val Ala Thr Phe Phe Ala Gly Phe Ile Val 
        195                 200                 205             


Gly Phe Ile Arg Gly Trp Lys Leu Thr Leu Val Ile Met Ala Ile Ser 
    210                 215                 220                 


Pro Ile Leu Gly Leu Ser Ala Ala Val Trp Ala Lys Ile Leu Ser Ala 
225                 230                 235                 240 


Phe Ser Asp Lys Glu Leu Ala Ala Tyr Ala Lys Ala Gly Ala Val Ala 
                245                 250                 255     


Glu Glu Ala Leu Gly Ala Ile Arg Thr Val Ile Ala Phe Gly Gly Gln 
            260                 265                 270         


Asn Lys Glu Leu Glu Arg Tyr Gln Lys His Leu Glu Asn Ala Lys Glu 
        275                 280                 285             


Ile Gly Ile Lys Lys Ala Ile Ser Ala Asn Ile Ser Met Gly Ile Ala 
    290                 295                 300                 


Phe Leu Leu Ile Tyr Ala Ser Tyr Ala Leu Ala Phe Trp Tyr Gly Ser 
305                 310                 315                 320 


Thr Leu Val Ile Ser Lys Glu Tyr Thr Ile Gly Asn Ala Met Thr Val 
                325                 330                 335     


Phe Phe Ser Ile Leu Ile Gly Ala Phe Ser Val Gly Gln Ala Ala Pro 
            340                 345                 350         


Cys Ile Asp Ala Phe Ala Asn Ala Arg Gly Ala Ala Tyr Val Ile Phe 
        355                 360                 365             


Asp Ile Ile Asp Asn Asn Pro Lys Ile Asp Ser Phe Ser Glu Arg Gly 
    370                 375                 380                 


His Lys Pro Asp Ser Ile Lys Gly Asn Leu Glu Phe Asn Asp Val His 
385                 390                 395                 400 


Phe Ser Tyr Pro Ser Arg Ala Asn Val Lys Ile Leu Lys Gly Leu Asn 
                405                 410                 415     


Leu Lys Val Gln Ser Gly Gln Thr Val Ala Leu Val Gly Ser Ser Gly 
            420                 425                 430         


Cys Gly Lys Ser Thr Thr Val Gln Leu Ile Gln Arg Leu Tyr Asp Pro 
        435                 440                 445             


Asp Glu Gly Thr Ile Asn Ile Asp Gly Gln Asp Ile Arg Asn Phe Asn 
    450                 455                 460                 


Val Asn Tyr Leu Arg Glu Ile Ile Gly Val Val Ser Gln Glu Pro Val 
465                 470                 475                 480 


Leu Phe Ser Thr Thr Ile Ala Glu Asn Ile Cys Tyr Gly Arg Gly Asn 
                485                 490                 495     


Val Thr Met Asp Glu Ile Lys Lys Ala Val Lys Glu Ala Asn Ala Tyr 
            500                 505                 510         


Glu Phe Ile Met Lys Leu Pro Gln Lys Phe Asp Thr Leu Val Gly Glu 
        515                 520                 525             


Arg Gly Ala Gln Leu Ser Gly Gly Gln Lys Gln Arg Ile Ala Ile Ala 
    530                 535                 540                 


Arg Ala Leu Val Arg Asn Pro Lys Ile Leu Leu Leu Asp Glu Ala Thr 
545                 550                 555                 560 


Ser Ala Leu Asp Thr Glu Ser Glu Ala Glu Val Gln Ala Ala Leu Asp 
                565                 570                 575     


Lys Ala Arg Glu Gly Arg Thr Thr Ile Val Ile Ala His Arg Leu Ser 
            580                 585                 590         


Thr Val Arg Asn Ala Asp Val Ile Ala Gly Phe Glu Asp Gly Val Ile 
        595                 600                 605             


Val Glu Gln Gly Ser His Ser Glu Leu Met Lys Lys Glu Gly Val Tyr 
    610                 615                 620                 


Phe Lys Leu Val Asn Met Gln Thr Ser Gly Ser Gln Ile Gln Ser Glu 
625                 630                 635                 640 


Glu Phe Glu Leu Asn Asp Glu Lys Ala Ala Thr Arg Met Ala Pro Asn 
                645                 650                 655     


Gly Trp Lys Ser Arg Leu Phe Arg His Ser Thr Gln Lys Asn Leu Lys 
            660                 665                 670         


Asn Ser Gln Met Cys Gln Lys Ser Leu Asp Val Glu Thr Asp Gly Leu 
        675                 680                 685             


Glu Ala Asn Val Pro Pro Val Ser Phe Leu Lys Val Leu Lys Leu Asn 
    690                 695                 700                 


Lys Thr Glu Trp Pro Tyr Phe Val Val Gly Thr Val Cys Ala Ile Ala 
705                 710                 715                 720 


Asn Gly Gly Leu Gln Pro Ala Phe Ser Val Ile Phe Ser Glu Ile Ile 
                725                 730                 735     


Ala Ile Phe Gly Pro Gly Asp Asp Ala Val Lys Gln Gln Lys Cys Asn 
            740                 745                 750         


Ile Phe Ser Leu Ile Phe Leu Phe Leu Gly Ile Ile Ser Phe Phe Thr 
        755                 760                 765             


Phe Phe Leu Gln Gly Phe Thr Phe Gly Lys Ala Gly Glu Ile Leu Thr 
    770                 775                 780                 


Arg Arg Leu Arg Ser Met Ala Phe Lys Ala Met Leu Arg Gln Asp Met 
785                 790                 795                 800 


Ser Trp Phe Asp Asp His Lys Asn Ser Thr Gly Ala Leu Ser Thr Arg 
                805                 810                 815     


Leu Ala Thr Asp Ala Ala Gln Val Gln Gly Ala Thr Gly Thr Arg Leu 
            820                 825                 830         


Ala Leu Ile Ala Gln Asn Ile Ala Asn Leu Gly Thr Gly Ile Ile Ile 
        835                 840                 845             


Ser Phe Ile Tyr Gly Trp Gln Leu Thr Leu Leu Leu Leu Ala Val Val 
    850                 855                 860                 


Pro Ile Ile Ala Val Ser Gly Ile Val Glu Met Lys Leu Leu Ala Gly 
865                 870                 875                 880 


Asn Ala Lys Arg Asp Lys Lys Glu Leu Glu Ala Ala Gly Lys Ile Ala 
                885                 890                 895     


Thr Glu Ala Ile Glu Asn Ile Arg Thr Val Val Ser Leu Thr Gln Glu 
            900                 905                 910         


Arg Lys Phe Glu Ser Met Tyr Val Glu Lys Leu Tyr Gly Pro Tyr Arg 
        915                 920                 925             


Asn Ser Val Gln Lys Ala His Ile Tyr Gly Ile Thr Phe Ser Ile Ser 
    930                 935                 940                 


Gln Ala Phe Met Tyr Phe Ser Tyr Ala Gly Cys Phe Arg Phe Gly Ala 
945                 950                 955                 960 


Tyr Leu Ile Val Asn Gly His Met Arg Phe Arg Asp Val Ile Leu Val 
                965                 970                 975     


Phe Ser Ala Ile Val Phe Gly Ala Val Ala Leu Gly His Ala Ser Ser 
            980                 985                 990         


Phe Ala Pro Asp Tyr Ala Lys Ala  Lys Leu Ser Ala Ala  His Leu Phe 
        995                 1000                 1005             


Met Leu  Phe Glu Arg Gln Pro  Leu Ile Asp Ser Tyr  Ser Glu Glu 
    1010                 1015                 1020             


Gly Leu  Lys Pro Asp Lys Phe  Glu Gly Asn Ile Thr  Phe Asn Glu 
    1025                 1030                 1035             


Val Val  Phe Asn Tyr Pro Thr  Arg Ala Asn Val Pro  Val Leu Gln 
    1040                 1045                 1050             


Gly Leu  Ser Leu Glu Val Lys  Lys Gly Gln Thr Leu  Ala Leu Val 
    1055                 1060                 1065             


Gly Ser  Ser Gly Cys Gly Lys  Ser Thr Val Val Gln  Leu Leu Glu 
    1070                 1075                 1080             


Arg Phe  Tyr Asp Pro Leu Ala  Gly Thr Val Phe Val  Asp Phe Gly 
    1085                 1090                 1095             


Phe Gln  Leu Leu Asp Gly Gln  Glu Ala Lys Lys Leu  Asn Val Gln 
    1100                 1105                 1110             


Trp Leu  Arg Ala Gln Leu Gly  Ile Val Ser Gln Glu  Pro Ile Leu 
    1115                 1120                 1125             


Phe Asp  Cys Ser Ile Ala Glu  Asn Ile Ala Tyr Gly  Asp Asn Ser 
    1130                 1135                 1140             


Arg Val  Val Ser Gln Asp Glu  Ile Val Ser Ala Ala  Lys Ala Ala 
    1145                 1150                 1155             


Asn Ile  His Pro Phe Ile Glu  Thr Leu Pro His Lys  Tyr Glu Thr 
    1160                 1165                 1170             


Arg Val  Gly Asp Lys Gly Thr  Gln Leu Ser Gly Gly  Gln Lys Gln 
    1175                 1180                 1185             


Arg Ile  Ala Ile Ala Arg Ala  Leu Ile Arg Gln Pro  Gln Ile Leu 
    1190                 1195                 1200             


Leu Leu  Asp Glu Ala Thr Ser  Ala Leu Asp Thr Glu  Ser Glu Lys 
    1205                 1210                 1215             


Val Val  Gln Glu Ala Leu Asp  Lys Ala Arg Glu Gly  Arg Thr Cys 
    1220                 1225                 1230             


Ile Val  Ile Ala His Arg Leu  Ser Thr Ile Gln Asn  Ala Asp Leu 
    1235                 1240                 1245             


Ile Val  Val Phe Gln Asn Gly  Arg Val Lys Glu His  Gly Thr His 
    1250                 1255                 1260             


Gln Gln  Leu Leu Ala Gln Lys  Gly Ile Tyr Phe Ser  Met Val Ser 
    1265                 1270                 1275             


Val Gln  Ala Gly Thr Gln Asn  Leu 
    1280                 1285     


<210>  4495
<211>  1232
<212>  PRT
<213>  Homo sapiens

<400>  4495

Met Asp Leu Glu Ala Ala Lys Asn Gly Thr Ala Trp Arg Pro Thr Ser 
1               5                   10                  15      


Ala Glu Gly Asp Phe Glu Leu Gly Ile Ser Ser Lys Gln Lys Arg Lys 
            20                  25                  30          


Lys Thr Lys Thr Val Lys Met Ile Gly Val Leu Thr Leu Phe Arg Tyr 
        35                  40                  45              


Ser Asp Trp Gln Asp Lys Leu Phe Met Ser Leu Gly Thr Ile Met Ala 
    50                  55                  60                  


Ile Ala His Gly Ser Gly Leu Pro Leu Met Met Ile Val Phe Gly Glu 
65                  70                  75                  80  


Met Thr Asp Lys Phe Val Asp Thr Ala Gly Asn Phe Ser Phe Pro Val 
                85                  90                  95      


Asn Phe Ser Leu Ser Leu Leu Asn Pro Gly Lys Ile Leu Glu Glu Glu 
            100                 105                 110         


Met Thr Arg Tyr Ala Tyr Tyr Tyr Ser Gly Leu Gly Ala Gly Val Leu 
        115                 120                 125             


Val Ala Ala Tyr Ile Gln Val Ser Phe Trp Thr Leu Ala Ala Gly Arg 
    130                 135                 140                 


Gln Ile Arg Lys Ile Arg Gln Lys Phe Phe His Ala Ile Leu Arg Gln 
145                 150                 155                 160 


Glu Ile Gly Trp Phe Asp Ile Asn Asp Thr Thr Glu Leu Asn Thr Arg 
                165                 170                 175     


Leu Thr Asp Asp Ile Ser Lys Ile Ser Glu Gly Ile Gly Asp Lys Val 
            180                 185                 190         


Gly Met Phe Phe Gln Ala Val Ala Thr Phe Phe Ala Gly Phe Ile Val 
        195                 200                 205             


Gly Phe Ile Arg Gly Trp Lys Leu Thr Leu Val Ile Met Ala Ile Ser 
    210                 215                 220                 


Pro Ile Leu Gly Leu Ser Ala Ala Val Trp Ala Lys Ile Leu Ser Ala 
225                 230                 235                 240 


Phe Ser Asp Lys Glu Leu Ala Ala Tyr Ala Lys Ala Gly Ala Val Ala 
                245                 250                 255     


Glu Glu Ala Leu Gly Ala Ile Arg Thr Val Ile Ala Phe Gly Gly Gln 
            260                 265                 270         


Asn Lys Glu Leu Glu Arg Tyr Gln Lys His Leu Glu Asn Ala Lys Glu 
        275                 280                 285             


Ile Gly Ile Lys Lys Ala Ile Ser Ala Asn Ile Ser Met Gly Ile Ala 
    290                 295                 300                 


Phe Leu Leu Ile Tyr Ala Ser Tyr Ala Leu Ala Phe Trp Tyr Gly Ser 
305                 310                 315                 320 


Thr Leu Val Ile Ser Lys Glu Tyr Thr Ile Gly Asn Ala Met Thr Val 
                325                 330                 335     


Phe Phe Ser Ile Leu Ile Gly Ala Phe Ser Val Gly Gln Ala Ala Pro 
            340                 345                 350         


Cys Ile Asp Ala Phe Ala Asn Ala Arg Gly Ala Ala Tyr Val Ile Phe 
        355                 360                 365             


Asp Ile Ile Asp Asn Asn Pro Lys Ile Asp Ser Phe Ser Glu Arg Gly 
    370                 375                 380                 


His Lys Pro Asp Ser Ile Lys Gly Asn Leu Glu Phe Asn Asp Val His 
385                 390                 395                 400 


Phe Ser Tyr Pro Ser Arg Ala Asn Val Lys Ile Leu Lys Gly Leu Asn 
                405                 410                 415     


Leu Lys Val Gln Ser Gly Gln Thr Val Ala Leu Val Gly Ser Ser Gly 
            420                 425                 430         


Cys Gly Lys Ser Thr Thr Val Gln Leu Ile Gln Arg Leu Tyr Asp Pro 
        435                 440                 445             


Asp Glu Gly Thr Ile Asn Ile Asp Gly Gln Asp Ile Arg Asn Phe Asn 
    450                 455                 460                 


Val Asn Tyr Leu Arg Glu Ile Ile Gly Val Val Ser Gln Glu Pro Val 
465                 470                 475                 480 


Leu Phe Ser Thr Thr Ile Ala Glu Asn Ile Cys Tyr Gly Arg Gly Asn 
                485                 490                 495     


Val Thr Met Asp Glu Ile Lys Lys Ala Val Lys Glu Ala Asn Ala Tyr 
            500                 505                 510         


Glu Phe Ile Met Lys Leu Pro Gln Lys Phe Asp Thr Leu Val Gly Glu 
        515                 520                 525             


Arg Gly Ala Gln Leu Ser Gly Gly Gln Lys Gln Arg Ile Ala Ile Ala 
    530                 535                 540                 


Arg Ala Leu Val Arg Asn Pro Lys Ile Leu Leu Leu Asp Glu Ala Thr 
545                 550                 555                 560 


Ser Ala Leu Asp Thr Glu Ser Glu Ala Glu Val Gln Ala Ala Leu Asp 
                565                 570                 575     


Lys Ala Arg Glu Gly Arg Thr Thr Ile Val Ile Ala His Arg Leu Ser 
            580                 585                 590         


Thr Val Arg Asn Ala Asp Val Ile Ala Gly Phe Glu Asp Gly Val Ile 
        595                 600                 605             


Val Glu Gln Gly Ser His Ser Glu Leu Met Lys Lys Glu Gly Val Tyr 
    610                 615                 620                 


Phe Lys Leu Val Asn Met Gln Thr Ser Gly Ser Gln Ile Gln Ser Glu 
625                 630                 635                 640 


Glu Phe Glu Leu Asn Asp Glu Lys Ala Ala Thr Arg Met Ala Pro Asn 
                645                 650                 655     


Gly Trp Lys Ser Arg Leu Phe Arg His Ser Thr Gln Lys Asn Leu Lys 
            660                 665                 670         


Asn Ser Gln Met Cys Gln Lys Ser Leu Asp Val Glu Thr Asp Gly Leu 
        675                 680                 685             


Glu Ala Asn Val Pro Pro Val Ser Phe Leu Lys Val Leu Lys Leu Asn 
    690                 695                 700                 


Lys Thr Glu Trp Pro Tyr Phe Val Val Gly Thr Val Cys Ala Ile Ala 
705                 710                 715                 720 


Asn Gly Gly Leu Gln Pro Ala Phe Ser Val Ile Phe Ser Glu Ile Ile 
                725                 730                 735     


Ala Ile Phe Gly Pro Gly Asp Asp Ala Val Lys Gln Gln Lys Cys Asn 
            740                 745                 750         


Ile Phe Ser Leu Ile Phe Leu Phe Leu Gly Ile Ile Ser Phe Phe Thr 
        755                 760                 765             


Phe Phe Leu Gln Gly Phe Thr Phe Gly Lys Ala Gly Glu Ile Leu Thr 
    770                 775                 780                 


Arg Arg Leu Arg Ser Met Ala Phe Lys Ala Met Leu Arg Gln Asp Met 
785                 790                 795                 800 


Ser Trp Phe Asp Asp His Lys Asn Ser Thr Gly Ala Leu Ser Thr Arg 
                805                 810                 815     


Leu Ala Thr Asp Ala Ala Gln Val Gln Gly Ala Thr Gly Thr Arg Leu 
            820                 825                 830         


Ala Leu Ile Ala Gln Asn Ile Ala Asn Leu Gly Thr Gly Ile Ile Ile 
        835                 840                 845             


Ser Phe Ile Tyr Gly Trp Gln Leu Thr Leu Leu Leu Leu Ala Val Val 
    850                 855                 860                 


Pro Ile Ile Ala Val Ser Gly Ile Val Glu Met Lys Leu Leu Ala Gly 
865                 870                 875                 880 


Asn Ala Lys Arg Asp Lys Lys Glu Leu Glu Ala Ala Gly Lys Ile Ala 
                885                 890                 895     


Thr Glu Ala Ile Glu Asn Ile Arg Thr Val Val Ser Leu Thr Gln Glu 
            900                 905                 910         


Arg Lys Phe Glu Ser Met Tyr Val Glu Lys Leu Tyr Gly Pro Tyr Arg 
        915                 920                 925             


Val Phe Ser Ala Ile Val Phe Gly Ala Val Ala Leu Gly His Ala Ser 
    930                 935                 940                 


Ser Phe Ala Pro Asp Tyr Ala Lys Ala Lys Leu Ser Ala Ala His Leu 
945                 950                 955                 960 


Phe Met Leu Phe Glu Arg Gln Pro Leu Ile Asp Ser Tyr Ser Glu Glu 
                965                 970                 975     


Gly Leu Lys Pro Asp Lys Phe Glu Gly Asn Ile Thr Phe Asn Glu Val 
            980                 985                 990         


Val Phe Asn Tyr Pro Thr Arg Ala  Asn Val Pro Val Leu  Gln Gly Leu 
        995                 1000                 1005             


Ser Leu  Glu Val Lys Lys Gly  Gln Thr Leu Ala Leu  Val Gly Ser 
    1010                 1015                 1020             


Ser Gly  Cys Gly Lys Ser Thr  Val Val Gln Leu Leu  Glu Arg Phe 
    1025                 1030                 1035             


Tyr Asp  Pro Leu Ala Gly Thr  Val Leu Leu Asp Gly  Gln Glu Ala 
    1040                 1045                 1050             


Lys Lys  Leu Asn Val Gln Trp  Leu Arg Ala Gln Leu  Gly Ile Val 
    1055                 1060                 1065             


Ser Gln  Glu Pro Ile Leu Phe  Asp Cys Ser Ile Ala  Glu Asn Ile 
    1070                 1075                 1080             


Ala Tyr  Gly Asp Asn Ser Arg  Val Val Ser Gln Asp  Glu Ile Val 
    1085                 1090                 1095             


Ser Ala  Ala Lys Ala Ala Asn  Ile His Pro Phe Ile  Glu Thr Leu 
    1100                 1105                 1110             


Pro His  Lys Tyr Glu Thr Arg  Val Gly Asp Lys Gly  Thr Gln Leu 
    1115                 1120                 1125             


Ser Gly  Gly Gln Lys Gln Arg  Ile Ala Ile Ala Arg  Ala Leu Ile 
    1130                 1135                 1140             


Arg Gln  Pro Gln Ile Leu Leu  Leu Asp Glu Ala Thr  Ser Ala Leu 
    1145                 1150                 1155             


Asp Thr  Glu Ser Glu Lys Val  Val Gln Glu Ala Leu  Asp Lys Ala 
    1160                 1165                 1170             


Arg Glu  Gly Arg Thr Cys Ile  Val Ile Ala His Arg  Leu Ser Thr 
    1175                 1180                 1185             


Ile Gln  Asn Ala Asp Leu Ile  Val Val Phe Gln Asn  Gly Arg Val 
    1190                 1195                 1200             


Lys Glu  His Gly Thr His Gln  Gln Leu Leu Ala Gln  Lys Gly Ile 
    1205                 1210                 1215             


Tyr Phe  Ser Met Val Ser Val  Gln Ala Gly Thr Gln  Asn Leu 
    1220                 1225                 1230         


<210>  4496
<211>  2377
<212>  PRT
<213>  Homo sapiens

<400>  4496

Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Thr Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Thr Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Thr Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Thr Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Thr Leu Leu Leu Asp Thr Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Thr Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Thr Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Thr Thr Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Thr Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Thr 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Thr Gln Phe Ser Glu 
385                 390                 395                 400 


Thr Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Thr Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Thr Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Thr Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Thr Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Thr Val Gly Ser Gly Lys Val Tyr Pro Thr 
            580                 585                 590         


Val His Thr Ser Pro Pro Pro Glu Thr Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Thr Leu Thr Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Thr Gln Ser 
625                 630                 635                 640 


Thr Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Thr Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Thr Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Thr Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Thr Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Thr Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Thr Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Thr Met Asp Asn 
    850                 855                 860                 


Val Ala Thr Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Thr Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Thr Val Phe Gln Ile Leu Thr Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Thr Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Thr Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Glu Ile Ser Lys Arg Glu 
                965                 970                 975     


Asp Ala Ser Gly Gln Leu Ser Cys Ile Gln Leu Pro Val Asp Ser Gln 
            980                 985                 990         


Gly Gly Asp Ala Asn Lys Ser Glu  Ser Glu Pro Asp Phe  Phe Ser Pro 
        995                 1000                 1005             


Ser Leu  Asp Gly Asp Gly Asp  Arg Lys Lys Cys Leu  Ala Leu Val 
    1010                 1015                 1020             


Ser Leu  Gly Glu His Pro Glu  Leu Arg Lys Ser Leu  Leu Pro Pro 
    1025                 1030                 1035             


Leu Ile  Ile His Thr Ala Ala  Thr Pro Met Ser Leu  Pro Lys Ser 
    1040                 1045                 1050             


Thr Ser  Thr Gly Leu Gly Glu  Ala Leu Gly Pro Ala  Ser Arg Arg 
    1055                 1060                 1065             


Thr Ser  Ser Ser Gly Ser Ala  Glu Pro Gly Ala Ala  His Glu Met 
    1070                 1075                 1080             


Lys Ser  Pro Pro Ser Ala Arg  Ser Ser Pro His Ser  Pro Trp Ser 
    1085                 1090                 1095             


Ala Ala  Ser Ser Trp Thr Ser  Arg Arg Ser Ser Arg  Asn Ser Leu 
    1100                 1105                 1110             


Gly Arg  Ala Pro Ser Leu Lys  Arg Arg Ser Pro Ser  Gly Glu Arg 
    1115                 1120                 1125             


Arg Ser  Leu Leu Ser Gly Glu  Gly Gln Glu Ser Gln  Asp Glu Glu 
    1130                 1135                 1140             


Glu Ser  Ser Glu Glu Glu Arg  Ala Ser Pro Ala Gly  Ser Asp His 
    1145                 1150                 1155             


Arg His  Arg Gly Ser Leu Glu  Arg Glu Ala Lys Ser  Ser Phe Asp 
    1160                 1165                 1170             


Leu Pro  Asp Thr Leu Gln Val  Pro Gly Leu His Arg  Thr Ala Ser 
    1175                 1180                 1185             


Gly Arg  Gly Ser Ala Ser Glu  His Gln Asp Cys Asn  Gly Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Arg Leu Ala Arg  Ala Leu Arg Pro Asp  Asp Pro Pro 
    1205                 1210                 1215             


Leu Asp  Gly Asp Asp Ala Asp  Asp Glu Gly Asn Leu  Ser Lys Gly 
    1220                 1225                 1230             


Glu Arg  Val Arg Ala Trp Ile  Arg Ala Arg Leu Pro  Ala Cys Cys 
    1235                 1240                 1245             


Leu Glu  Arg Asp Ser Trp Ser  Ala Tyr Ile Phe Pro  Pro Gln Ser 
    1250                 1255                 1260             


Arg Phe  Arg Leu Leu Cys His  Arg Ile Ile Thr His  Lys Met Phe 
    1265                 1270                 1275             


Asp His  Val Val Leu Val Ile  Ile Phe Leu Asn Cys  Ile Thr Ile 
    1280                 1285                 1290             


Ala Met  Glu Arg Pro Lys Ile  Asp Pro His Ser Ala  Glu Arg Ile 
    1295                 1300                 1305             


Phe Leu  Thr Leu Ser Asn Tyr  Ile Phe Thr Ala Val  Phe Leu Ala 
    1310                 1315                 1320             


Glu Met  Thr Val Lys Val Val  Ala Leu Gly Trp Cys  Phe Gly Glu 
    1325                 1330                 1335             


Gln Ala  Tyr Leu Arg Ser Ser  Trp Asn Val Leu Asp  Gly Leu Leu 
    1340                 1345                 1350             


Val Leu  Ile Ser Val Ile Asp  Ile Leu Val Ser Met  Val Ser Asp 
    1355                 1360                 1365             


Ser Gly  Thr Lys Ile Leu Gly  Met Leu Arg Val Leu  Arg Leu Leu 
    1370                 1375                 1380             


Arg Thr  Leu Arg Pro Leu Arg  Val Ile Ser Arg Ala  Gln Gly Leu 
    1385                 1390                 1395             


Lys Leu  Val Val Glu Thr Leu  Met Ser Ser Leu Lys  Pro Ile Gly 
    1400                 1405                 1410             


Asn Ile  Val Val Ile Cys Cys  Ala Phe Phe Ile Ile  Phe Gly Ile 
    1415                 1420                 1425             


Leu Gly  Val Gln Leu Phe Lys  Gly Lys Phe Phe Val  Cys Gln Gly 
    1430                 1435                 1440             


Glu Asp  Thr Arg Asn Ile Thr  Asn Lys Ser Asp Cys  Ala Glu Ala 
    1445                 1450                 1455             


Ser Tyr  Arg Trp Val Arg His  Lys Tyr Asn Phe Asp  Asn Leu Gly 
    1460                 1465                 1470             


Gln Ala  Leu Met Ser Leu Phe  Val Leu Ala Ser Lys  Asp Gly Trp 
    1475                 1480                 1485             


Val Asp  Ile Met Tyr Asp Gly  Leu Asp Ala Val Gly  Val Asp Gln 
    1490                 1495                 1500             


Gln Pro  Ile Met Asn His Asn  Pro Trp Met Leu Leu  Tyr Phe Ile 
    1505                 1510                 1515             


Ser Phe  Leu Leu Ile Val Ala  Phe Phe Val Leu Asn  Met Phe Val 
    1520                 1525                 1530             


Gly Val  Val Val Glu Asn Phe  His Lys Cys Arg Gln  His Gln Glu 
    1535                 1540                 1545             


Glu Glu  Glu Ala Arg Arg Arg  Glu Glu Lys Arg Leu  Arg Arg Leu 
    1550                 1555                 1560             


Glu Lys  Lys Arg Arg Asn Leu  Met Leu Asp Asp Val  Ile Ala Ser 
    1565                 1570                 1575             


Gly Ser  Ser Ala Ser Ala Ala  Ser Glu Ala Gln Cys  Lys Pro Tyr 
    1580                 1585                 1590             


Tyr Ser  Asp Tyr Ser Arg Phe  Arg Leu Leu Val His  His Leu Cys 
    1595                 1600                 1605             


Thr Ser  His Tyr Leu Asp Leu  Phe Ile Thr Gly Val  Ile Gly Leu 
    1610                 1615                 1620             


Asn Val  Val Thr Met Ala Met  Glu His Tyr Gln Gln  Pro Gln Ile 
    1625                 1630                 1635             


Leu Asp  Glu Ala Leu Lys Ile  Cys Asn Tyr Ile Phe  Thr Val Ile 
    1640                 1645                 1650             


Phe Val  Leu Glu Ser Val Phe  Lys Leu Val Ala Phe  Gly Phe Arg 
    1655                 1660                 1665             


Arg Phe  Phe Gln Asp Arg Trp  Asn Gln Leu Asp Leu  Ala Ile Val 
    1670                 1675                 1680             


Leu Leu  Ser Ile Met Gly Ile  Thr Leu Glu Glu Ile  Glu Val Asn 
    1685                 1690                 1695             


Ala Ser  Leu Pro Ile Asn Pro  Thr Ile Ile Arg Ile  Met Arg Val 
    1700                 1705                 1710             


Leu Arg  Ile Ala Arg Val Leu  Lys Leu Leu Lys Met  Ala Val Gly 
    1715                 1720                 1725             


Met Arg  Ala Leu Leu Asp Thr  Val Met Gln Ala Leu  Pro Gln Val 
    1730                 1735                 1740             


Gly Asn  Leu Gly Leu Leu Phe  Met Leu Leu Phe Phe  Ile Phe Ala 
    1745                 1750                 1755             


Ala Leu  Gly Val Glu Leu Phe  Gly Asp Leu Glu Cys  Asp Glu Thr 
    1760                 1765                 1770             


His Pro  Cys Glu Gly Leu Gly  Arg His Ala Thr Phe  Arg Asn Phe 
    1775                 1780                 1785             


Gly Met  Ala Phe Leu Thr Leu  Phe Arg Val Ser Thr  Gly Asp Asn 
    1790                 1795                 1800             


Trp Asn  Gly Ile Met Lys Asp  Thr Leu Arg Asp Cys  Asp Gln Glu 
    1805                 1810                 1815             


Ser Thr  Cys Tyr Asn Thr Val  Ile Ser Pro Ile Tyr  Phe Val Ser 
    1820                 1825                 1830             


Phe Val  Leu Thr Ala Gln Phe  Val Leu Val Asn Val  Val Ile Ala 
    1835                 1840                 1845             


Val Leu  Met Lys His Leu Glu  Glu Ser Asn Lys Glu  Ala Lys Glu 
    1850                 1855                 1860             


Glu Ala  Glu Leu Glu Ala Glu  Leu Glu Leu Glu Met  Lys Thr Leu 
    1865                 1870                 1875             


Ser Pro  Gln Pro His Ser Pro  Leu Gly Ser Pro Phe  Leu Trp Pro 
    1880                 1885                 1890             


Gly Val  Glu Gly Pro Asp Ser  Pro Asp Ser Pro Lys  Pro Gly Ala 
    1895                 1900                 1905             


Leu His  Pro Ala Ala His Ala  Arg Ser Ala Ser His  Phe Ser Leu 
    1910                 1915                 1920             


Glu His  Pro Thr Asp Arg Gln  Leu Phe Asp Thr Ile  Ser Leu Leu 
    1925                 1930                 1935             


Ile Gln  Gly Ser Leu Glu Trp  Glu Leu Lys Leu Met  Asp Glu Leu 
    1940                 1945                 1950             


Ala Gly  Pro Gly Gly Gln Pro  Ser Ala Phe Pro Ser  Ala Pro Ser 
    1955                 1960                 1965             


Leu Gly  Gly Ser Asp Pro Gln  Ile Pro Leu Ala Glu  Met Glu Ala 
    1970                 1975                 1980             


Leu Ser  Leu Thr Ser Glu Ile  Val Ser Glu Pro Ser  Cys Ser Leu 
    1985                 1990                 1995             


Ala Leu  Thr Asp Asp Ser Leu  Pro Asp Asp Met His  Thr Leu Leu 
    2000                 2005                 2010             


Leu Ser  Ala Leu Glu Ser Asn  Met Gln Pro His Pro  Thr Glu Leu 
    2015                 2020                 2025             


Pro Gly  Pro Asp Leu Leu Thr  Val Arg Lys Ser Gly  Val Ser Arg 
    2030                 2035                 2040             


Thr His  Ser Leu Pro Asn Asp  Ser Tyr Met Cys Arg  His Gly Ser 
    2045                 2050                 2055             


Thr Ala  Glu Gly Pro Leu Gly  His Arg Gly Trp Gly  Leu Pro Lys 
    2060                 2065                 2070             


Ala Gln  Ser Gly Ser Val Leu  Ser Val His Ser Gln  Pro Ala Asp 
    2075                 2080                 2085             


Thr Ser  Tyr Ile Leu Gln Leu  Pro Lys Asp Ala Pro  His Leu Leu 
    2090                 2095                 2100             


Gln Pro  His Ser Ala Pro Thr  Trp Gly Thr Ile Pro  Lys Leu Pro 
    2105                 2110                 2115             


Pro Pro  Gly Arg Ser Pro Leu  Ala Gln Arg Pro Leu  Arg Arg Gln 
    2120                 2125                 2130             


Ala Ala  Ile Arg Thr Asp Ser  Leu Asp Val Gln Gly  Leu Gly Ser 
    2135                 2140                 2145             


Arg Glu  Asp Leu Leu Ala Glu  Val Ser Gly Pro Ser  Pro Pro Leu 
    2150                 2155                 2160             


Ala Arg  Ala Tyr Ser Phe Trp  Gly Gln Ser Ser Thr  Gln Ala Gln 
    2165                 2170                 2175             


Gln His  Ser Arg Ser His Ser  Lys Ile Ser Lys His  Met Thr Pro 
    2180                 2185                 2190             


Pro Ala  Pro Cys Pro Gly Pro  Glu Pro Asn Trp Gly  Lys Gly Pro 
    2195                 2200                 2205             


Pro Glu  Thr Arg Ser Ser Leu  Glu Leu Asp Thr Glu  Leu Ser Trp 
    2210                 2215                 2220             


Ile Ser  Gly Asp Leu Leu Pro  Pro Gly Gly Gln Glu  Glu Pro Pro 
    2225                 2230                 2235             


Ser Pro  Arg Asp Leu Lys Lys  Cys Tyr Ser Val Glu  Ala Gln Ser 
    2240                 2245                 2250             


Cys Gln  Arg Arg Pro Thr Ser  Trp Leu Asp Glu Gln  Arg Arg His 
    2255                 2260                 2265             


Ser Ile  Ala Val Ser Cys Leu  Asp Ser Gly Ser Gln  Pro His Leu 
    2270                 2275                 2280             


Gly Thr  Asp Pro Ser Asn Leu  Gly Gly Gln Pro Leu  Gly Gly Pro 
    2285                 2290                 2295             


Gly Ser  Arg Pro Lys Lys Lys  Leu Ser Pro Pro Ser  Ile Thr Ile 
    2300                 2305                 2310             


Asp Pro  Pro Glu Ser Gln Gly  Pro Arg Thr Pro Pro  Ser Pro Gly 
    2315                 2320                 2325             


Ile Cys  Leu Arg Arg Arg Ala  Pro Ser Ser Asp Ser  Lys Asp Pro 
    2330                 2335                 2340             


Leu Ala  Ser Gly Pro Pro Asp  Ser Met Ala Ala Ser  Pro Ser Pro 
    2345                 2350                 2355             


Lys Lys  Asp Val Leu Ser Leu  Ser Gly Leu Ser Ser  Asp Pro Ala 
    2360                 2365                 2370             


Asp Leu  Asp Pro 
    2375         


<210>  4497
<211>  948
<212>  PRT
<213>  Homo sapiens

<400>  4497

Met Val Ser Arg Cys Ser Cys Leu Gly Val Gln Cys Leu Leu Leu Ser 
1               5                   10                  15      


Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His Tyr 
            20                  25                  30          


Ser Val Tyr Glu Glu Ala Arg His Gly Thr Phe Val Gly Arg Ile Ala 
        35                  40                  45              


Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Gln Arg Leu Phe Arg 
    50                  55                  60                  


Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln Asn 
65                  70                  75                  80  


Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys Gly 
                85                  90                  95      


Arg Ser Val Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg Pro 
            100                 105                 110         


Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp Asn 
        115                 120                 125             


Pro Pro Arg Phe Ser Val Thr Glu Gln Lys Leu Ser Ile Pro Glu Ser 
    130                 135                 140                 


Arg Leu Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala Asp 
145                 150                 155                 160 


Val Gly Glu Asn Ala Leu Leu Thr Tyr Lys Leu Ser Pro Asn Glu Tyr 
                165                 170                 175     


Phe Val Leu Asp Ile Ile Asn Lys Lys Asp Lys Asp Lys Phe Pro Val 
            180                 185                 190         


Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Glu Asn Pro Gln Leu Lys 
        195                 200                 205             


Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Phe Thr Gly Ser 
    210                 215                 220                 


Val Ser Leu Leu Ile Leu Val Leu Asp Ala Asn Asp Asn Ala Pro Ile 
225                 230                 235                 240 


Phe Asp Arg Pro Val Tyr Glu Val Lys Met Tyr Glu Asn Gln Val Asn 
                245                 250                 255     


Gln Thr Leu Val Ile Arg Leu Asn Ala Ser Asp Ser Asp Glu Gly Ile 
            260                 265                 270         


Asn Lys Glu Met Met Tyr Ser Phe Ser Ser Leu Val Pro Pro Thr Ile 
        275                 280                 285             


Arg Arg Lys Phe Trp Ile Asn Glu Arg Thr Gly Glu Ile Lys Val Asn 
    290                 295                 300                 


Asp Ala Ile Asp Phe Glu Asp Ser Asn Thr Tyr Glu Ile His Val Asp 
305                 310                 315                 320 


Val Thr Asp Lys Gly Asn Pro Pro Met Val Gly His Cys Thr Val Leu 
                325                 330                 335     


Val Glu Leu Leu Asp Glu Asn Asp Asn Ser Pro Glu Val Ile Val Thr 
            340                 345                 350         


Ser Leu Ser Leu Pro Val Lys Glu Asp Ala Gln Val Gly Thr Val Ile 
        355                 360                 365             


Ala Leu Ile Ser Val Ser Asp His Asp Ser Gly Ala Asn Gly Gln Val 
    370                 375                 380                 


Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr Tyr 
385                 390                 395                 400 


Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu Arg 
                405                 410                 415     


Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser Pro 
            420                 425                 430         


Pro Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Ala Phe Ala Gln Ser Glu Tyr Thr Val Phe Val Lys 
    450                 455                 460                 


Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp Asp 
465                 470                 475                 480 


Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu Arg 
                485                 490                 495     


Arg Leu Gly Glu Arg Ser Leu Ser Ser Tyr Val Ser Val His Ala Glu 
            500                 505                 510         


Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu Glu 
        515                 520                 525             


Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Gly Gly Val Pro Pro Leu 
    530                 535                 540                 


Gly Ser Asn Leu Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Leu Leu Ala Ser Pro Ala Gly Ser Ala Gly Gly Ala Val 
                565                 570                 575     


Ser Glu Leu Val Leu Arg Ser Val Val Ala Gly His Val Val Ala Lys 
            580                 585                 590         


Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Glu Leu Gln Ser Ala Ala Val Gly Ala Arg Ile Pro Phe Arg Val Gly 
    610                 615                 620                 


Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr Asp 
625                 630                 635                 640 


Ser Pro Arg Gln Arg Leu Leu Val Leu Val Lys Asp His Gly Glu Pro 
                645                 650                 655     


Ser Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Gly Ser 
            660                 665                 670         


Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Val Gly Val Ala Pro Glu 
        675                 680                 685             


Val Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile Cys Ala 
    690                 695                 700                 


Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala Leu Arg 
705                 710                 715                 720 


Cys Ser Ala Ala Pro Thr Glu Gly Ala Cys Gly Pro Val Lys Pro Thr 
                725                 730                 735     


Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln Gln Arg 
            740                 745                 750         


Arg Gln Arg Val Cys Ser Gly Glu Gly Leu Pro Lys Ala Asp Leu Met 
        755                 760                 765             


Ala Phe Ser Pro Ser Leu Pro Pro Cys Pro Met Val Asp Val Asp Gly 
    770                 775                 780                 


Glu Asp Gln Ser Ile Gly Gly Asp His Ser Arg Lys Pro Arg Gln Pro 
785                 790                 795                 800 


Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser 
                805                 810                 815     


Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly 
            820                 825                 830         


Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu 
        835                 840                 845             


Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser 
    850                 855                 860                 


Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly 
865                 870                 875                 880 


Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser 
                885                 890                 895     


Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile 
            900                 905                 910         


Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp 
    930                 935                 940                 


Asn Ser Asp Gln 
945             


<210>  4498
<211>  1007
<212>  PRT
<213>  Homo sapiens

<400>  4498

Met Glu Gln Ala Gly Thr Arg Pro Ala Ala Thr Glu His Pro Arg Leu 
1               5                   10                  15      


Arg Arg Pro Met Pro Trp Leu Leu Leu Leu Pro Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Pro Gly Pro Ala Ala Ser Gln Leu Arg Tyr Ser Val 
        35                  40                  45              


Pro Glu Glu Gln Ala Pro Gly Ala Leu Val Gly Asn Val Ala Arg Ala 
    50                  55                  60                  


Leu Gly Leu Glu Leu Arg Arg Leu Gly Pro Gly Cys Leu Arg Ile Asn 
65                  70                  75                  80  


His Leu Gly Ala Pro Ser Pro Arg Tyr Leu Glu Leu Asp Leu Thr Ser 
                85                  90                  95      


Gly Ala Leu Phe Val Asn Glu Arg Ile Asp Arg Glu Ala Leu Cys Glu 
            100                 105                 110         


Gln Arg Pro Arg Cys Leu Leu Ser Leu Glu Val Leu Ala His Asn Pro 
        115                 120                 125             


Val Ala Val Ser Ala Val Glu Val Glu Ile Leu Asp Ile Asn Asp Asn 
    130                 135                 140                 


Ser Pro Arg Phe Pro Arg Pro Asn Tyr Gln Leu Gln Val Ser Glu Ser 
145                 150                 155                 160 


Val Ala Pro Gly Ala Arg Phe His Ile Glu Ser Ala Gln Asp Pro Asp 
                165                 170                 175     


Val Gly Ala Asn Ser Val Gln Thr Tyr Glu Leu Ser Pro Ser Glu His 
            180                 185                 190         


Phe Glu Leu Asp Leu Lys Pro Leu Gln Glu Asn Ser Lys Val Leu Glu 
        195                 200                 205             


Leu Val Leu Arg Lys Gly Leu Asp Arg Glu Gln Ala Ala Leu His His 
    210                 215                 220                 


Leu Val Leu Thr Ala Val Asp Gly Gly Ile Pro Ala Arg Ser Gly Thr 
225                 230                 235                 240 


Ala Gln Ile Ser Val Arg Val Leu Asp Thr Asn Asp Asn Ser Pro Ala 
                245                 250                 255     


Phe Asp Gln Ser Thr Tyr Arg Val Gln Leu Arg Glu Asp Ser Pro Pro 
            260                 265                 270         


Gly Thr Leu Val Val Lys Leu Asn Ala Ser Asp Pro Asp Glu Gly Ser 
        275                 280                 285             


Asn Gly Glu Leu Arg Tyr Ser Leu Ser Ser Tyr Thr Ser Asp Arg Glu 
    290                 295                 300                 


Arg Gln Leu Phe Ser Ile Asp Ala Ser Thr Gly Glu Val Arg Val Ile 
305                 310                 315                 320 


Gly Gly Leu Asp Tyr Glu Glu Ala Ser Ser Tyr Gln Ile Tyr Val Gln 
                325                 330                 335     


Ala Thr Asp Arg Gly Pro Val Pro Met Ala Gly His Cys Lys Val Leu 
            340                 345                 350         


Val Asp Ile Val Asp Val Asn Asp Asn Ala Pro Glu Val Val Leu Thr 
        355                 360                 365             


Asp Leu Tyr Ser Pro Val Pro Glu Asn Ala Thr Pro Asn Thr Ile Val 
    370                 375                 380                 


Ala Val Leu Ser Val Asn Asp Gln Asp Ser Gly Pro Asn Arg Lys Val 
385                 390                 395                 400 


Ser Leu Gly Leu Glu Ala Thr Leu Pro Phe Arg Leu Asn Gly Phe Gly 
                405                 410                 415     


Asn Ser Tyr Thr Leu Val Val Ser Gly Pro Leu Asp Arg Glu Arg Val 
            420                 425                 430         


Ala Val Tyr Asn Ile Thr Val Thr Ala Thr Asp Gly Gly Ile Pro Gln 
        435                 440                 445             


Leu Thr Ser Leu Arg Thr Leu Lys Val Glu Ile Ser Asp Ile Asn Asp 
    450                 455                 460                 


Asn Pro Pro Ser Phe Leu Glu Asp Ser Tyr Ser Ile Tyr Ile Gln Glu 
465                 470                 475                 480 


Asn Asn Leu Pro Gly Val Leu Leu Cys Thr Val Gln Ala Thr Asp Pro 
                485                 490                 495     


Asp Glu Lys Glu Asn Ala Glu Val Thr Tyr Ser Leu Leu Glu Arg Glu 
            500                 505                 510         


Ile Gln Gly Leu Pro Val Thr Ser Tyr Val Ser Ile Asn Ser Ala Ser 
        515                 520                 525             


Gly Ser Leu Tyr Ala Val Asn Ser Phe Asp Tyr Glu Lys Phe Arg Glu 
    530                 535                 540                 


Phe Phe Val Thr Val Glu Ala Gln Asp Lys Gly Ser Pro Pro Leu Ser 
545                 550                 555                 560 


Ser Thr Val Thr Ala Asn Val Tyr Val Val Asp Met Asn Asp His Ala 
                565                 570                 575     


Pro His Ile Leu Tyr Pro Thr Ser Thr Asn Ser Ser Ala Ala Phe Glu 
            580                 585                 590         


Met Val Pro Arg Thr Ala Pro Ala Gly Tyr Leu Val Thr Lys Val Ile 
        595                 600                 605             


Ala Met Asp Ser Asp Ser Gly Gln Asn Ala Trp Leu Phe Tyr His Leu 
    610                 615                 620                 


Ala Gln Thr Ser Asp Leu Asp Leu Phe Lys Val Glu Leu His Thr Gly 
625                 630                 635                 640 


Glu Ile Arg Thr Thr Arg Lys Met Gly Asp Glu Ser Gly Ser Thr Phe 
                645                 650                 655     


Asn Leu Thr Val Val Val Arg Asp Asn Gly Glu Pro Ser Leu Ser Ala 
            660                 665                 670         


Ser Val Ala Ile Thr Val Ala Val Val Asp Arg Val Ser Lys Ile Leu 
        675                 680                 685             


Pro Asp Thr Gln Arg His Val Lys Ser Pro Arg Thr Tyr Ser Glu Ile 
    690                 695                 700                 


Thr Leu Tyr Leu Ile Ile Ala Leu Ser Thr Val Ser Phe Ile Phe Leu 
705                 710                 715                 720 


Leu Thr Ile Ile Ile Leu Ser Ile Ile Lys Cys Tyr Arg Tyr Thr Ala 
                725                 730                 735     


Tyr Gly Thr Ala Cys Cys Gly Gly Phe Cys Gly Val Arg Glu Arg Ser 
            740                 745                 750         


Pro Ala Glu Leu Tyr Lys Gln Ala Asn Asn Asn Ile Asp Ala Arg Ile 
        755                 760                 765             


Pro His Gly Leu Lys Val Gln Pro His Phe Ile Glu Val Arg Gly Asn 
    770                 775                 780                 


Gly Ser Leu Thr Lys Thr Tyr Cys Tyr Lys Ala Cys Leu Thr Ala Gly 
785                 790                 795                 800 


Ser Gly Ser Asp Thr Phe Met Phe Tyr Asn Thr Gly Ala Gln Thr Gly 
                805                 810                 815     


Pro Gly Pro Ser Gly Ala Gln Ala Ala Val Thr Asp Ser Arg Asn Leu 
            820                 825                 830         


Thr Gly Gln Ser Gly Gln Asn Ala Gly Asn Leu Ile Ile Leu Lys Asn 
        835                 840                 845             


Glu Ala Val Ser Gln Asn Glu Pro Arg Gln Pro Asn Pro Asp Trp Arg 
    850                 855                 860                 


Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser Val His Leu Glu 
865                 870                 875                 880 


Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro Asp Gln Gln Trp 
                885                 890                 895     


Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala Gly Glu Val Ser 
            900                 905                 910         


Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr 
        915                 920                 925             


Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys 
    930                 935                 940                 


Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro 
945                 950                 955                 960 


Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys 
                965                 970                 975     


Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln 
            980                 985                 990         


Glu Lys Lys Glu Lys Gly Asn Ser  Thr Thr Asp Asn Ser  Asp Gln 
        995                 1000                 1005         


<210>  4499
<211>  963
<212>  PRT
<213>  Homo sapiens

<400>  4499

Met Val Gly Cys Gly Val Ala Val Leu Cys Leu Trp Val Ser Cys Gly 
1               5                   10                  15      


Ala Ala Ala Gly Gln Leu Glu Tyr Ser Val Pro Glu Glu Thr Glu Arg 
            20                  25                  30          


Gly Val Ala Val Gly Asn Leu Ser Ala Asp Leu Arg Leu Pro Ala Ala 
        35                  40                  45              


Ala Met Ser Ser Arg Asn Phe Arg Phe Leu Ser Ser His Arg Glu Leu 
    50                  55                  60                  


Tyr Phe Gly Val Asp Leu Pro Ser Gly Asn Leu Val Val Arg Glu Pro 
65                  70                  75                  80  


Ala Asp Arg Glu Gln Leu Cys Arg Ala Lys Ala Ala Cys Val Leu Thr 
                85                  90                  95      


Tyr Asp Leu Val Leu Glu Asp Pro Leu Glu Leu His Lys Ile Arg Ile 
            100                 105                 110         


His Val Leu Asp Thr Asn Asp Asn Ser Pro Leu Phe Pro Ala Gly Asp 
        115                 120                 125             


Val Gln Leu His Ile Pro Glu Phe Leu Thr Pro Gly Ala Arg Phe Thr 
    130                 135                 140                 


Leu Pro Asn Ala Gln Asp Asp Asp Glu Gly Ser Asn Gly Ile Leu Ser 
145                 150                 155                 160 


Tyr Ser Leu Ser Pro Ser Gln His Phe Arg Leu Asp Met Gly Ser Arg 
                165                 170                 175     


Val Asp Gly Ser Glu Tyr Pro Glu Leu Val Leu Glu Lys Ala Leu Asp 
            180                 185                 190         


Arg Glu Gln Arg Ala Thr His Leu Leu Val Leu Thr Ala Arg Asp Gly 
        195                 200                 205             


Gly Leu Pro Ala Arg Ser Gly Asp Ala Gln Val Thr Ile Ile Val Val 
    210                 215                 220                 


Asp Thr Asn Asp Asn Ala Pro Val Phe Glu Arg Ser Val Tyr Arg Thr 
225                 230                 235                 240 


Lys Val Pro Glu Thr Ala Pro Asn Gly Thr Val Leu Phe Arg Val Gln 
                245                 250                 255     


Ala Leu Asp Pro Asp Glu Gly Ser Asn Gly Glu Val Gln Tyr Ser Leu 
            260                 265                 270         


Ser Asn Ser Thr Gln Ala Glu Leu Arg His Arg Phe His Val His Pro 
        275                 280                 285             


Lys Ser Gly Glu Val Gln Val Ala Ala Ser Leu Gly Pro Pro Glu Thr 
    290                 295                 300                 


Leu Leu Glu Ala Tyr Ile Glu Ala Arg Asp Glu Gly Val Phe Gly Leu 
305                 310                 315                 320 


Ala Ser Thr Ala Lys Leu Leu Val Glu Val Thr Asp Val Asn Asp His 
                325                 330                 335     


Ala Pro Glu Leu Asp Phe Leu Thr Leu Ser Asn Pro Val Pro Glu Asp 
            340                 345                 350         


Ala Ala Pro Gly Thr Val Ile Ala Leu Phe Ser Val Lys Asp Glu Asp 
        355                 360                 365             


Leu Asp Ser Asn Gly Arg Val Ile Cys Gly Met Ser Ser Ala Gly Pro 
    370                 375                 380                 


Phe Gln Leu Thr Ala Ser Phe Asp Asn Tyr Tyr Ser Leu Leu Ile Asp 
385                 390                 395                 400 


Gly Pro Leu Asp Arg Glu Gln Ile Ser Glu Tyr Gln Val Leu Ile Thr 
                405                 410                 415     


Ala Ser Asp Ser Gly Ser Pro Pro Leu Ser Thr Arg Arg Thr Ile Thr 
            420                 425                 430         


Val Ser Val Ala Asp Val Asn Asp Asn Thr Pro Asn Phe Pro Gln Pro 
        435                 440                 445             


Gln Gln Glu Leu Phe Val Ala Glu Asn Asn Gly Pro Gly Ala Ser Leu 
    450                 455                 460                 


Gly Arg Val Phe Ala Gln Asp Pro Asp Leu Gly Lys Asn Gly Leu Val 
465                 470                 475                 480 


Ser Tyr Glu Leu Leu Asp Val Ile Ser Glu Gly Pro Ser Ala Ser Ser 
                485                 490                 495     


Leu Leu Ala Val Glu Ser Ser Ser Gly Ala Ile Thr Ala Lys Thr Ser 
            500                 505                 510         


Phe Asp Phe Glu Gln Leu Arg Gly Phe His Phe Gln Val Glu Gly Arg 
        515                 520                 525             


Asp Gly Gly Ile Pro Pro Arg Ser Ala Thr Val Thr Ile Asn Leu Phe 
    530                 535                 540                 


Val Val Asp Arg Asn Asp Asn Tyr Pro Val Ile Leu Phe Pro Leu Pro 
545                 550                 555                 560 


Arg Asn Gly Ser Val Pro Val Glu Ile Val Pro Arg Ser Ala Arg Thr 
                565                 570                 575     


Gly His Leu Val Thr Lys Val Val Ala Glu Asp Ala Asp Ser Gly Ser 
            580                 585                 590         


Asn Ala Trp Leu Ser Tyr His Ile Ser Arg Ala Ser Asp Ser Ser Leu 
        595                 600                 605             


Phe Arg Ile Ser Ala Asn Ile Gly Glu Leu Arg Thr Ala Arg Leu Val 
    610                 615                 620                 


Leu Pro Thr Asp Ala Val Lys Gln Arg Val Val Val Val Val Arg Asp 
625                 630                 635                 640 


His Gly Asp Pro Pro Leu Ser Ser Ser Val Thr Leu Gly Val Leu Leu 
                645                 650                 655     


Ser Asn Ser Val Pro Gln Leu Leu Pro Asp Phe Glu Asp Val Trp Glu 
            660                 665                 670         


Pro Gly Gly Gln Leu Ser Ala Gln Asn Leu Tyr Leu Val Ile Ala Leu 
        675                 680                 685             


Ala Cys Ile Ser Phe Leu Phe Leu Gly Cys Leu Leu Phe Phe Val Cys 
    690                 695                 700                 


Thr Lys Leu His Gln Ser Pro Gly Cys Cys Ala Gln Ser Cys Cys Arg 
705                 710                 715                 720 


Ser Thr Glu Asp Leu Arg Tyr Gly Ser Lys Met Val Ser Asn Pro Cys 
                725                 730                 735     


Met Thr Ser Ala Thr Ile Asp Val Thr Thr Val Glu Arg Leu Ser Gln 
            740                 745                 750         


Thr Tyr Leu Tyr Arg Ala Ser Leu Gly Leu Gly Ser Asp Asn Asn Ser 
        755                 760                 765             


Leu Leu Leu Arg Gly Glu Tyr Asn Ala Ala Asp Leu Arg Asn Leu Ala 
    770                 775                 780                 


Thr Gly Val Gly Leu Asn Leu Pro Ile Ser Cys Ile Gln Ile Arg Asn 
785                 790                 795                 800 


Arg Lys Gly Asp His Ala Asn Val Asn Ala Met Pro Arg Gln Pro Asn 
                805                 810                 815     


Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser 
            820                 825                 830         


Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro 
        835                 840                 845             


Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala 
    850                 855                 860                 


Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp 
865                 870                 875                 880 


Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu 
                885                 890                 895     


Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile 
            900                 905                 910         


Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr 
        915                 920                 925             


Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly 
    930                 935                 940                 


Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn 
945                 950                 955                 960 


Ser Asp Gln 
            


<210>  4500
<211>  948
<212>  PRT
<213>  Homo sapiens

<400>  4500

Met Val Ser Arg Cys Ser Cys Leu Gly Val Gln Cys Leu Leu Leu Ser 
1               5                   10                  15      


Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His Tyr 
            20                  25                  30          


Ser Val Tyr Glu Glu Ala Arg His Gly Thr Phe Val Gly Arg Ile Ala 
        35                  40                  45              


Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Gln Arg Leu Phe Arg 
    50                  55                  60                  


Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln Asn 
65                  70                  75                  80  


Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys Gly 
                85                  90                  95      


Arg Ser Val Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg Pro 
            100                 105                 110         


Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp Asn 
        115                 120                 125             


Pro Pro Arg Phe Ser Val Thr Glu Gln Lys Leu Ser Ile Pro Glu Ser 
    130                 135                 140                 


Arg Leu Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala Asp 
145                 150                 155                 160 


Val Gly Glu Asn Ala Leu Leu Thr Tyr Lys Leu Ser Pro Asn Glu Tyr 
                165                 170                 175     


Phe Val Leu Asp Ile Ile Asn Lys Lys Asp Lys Asp Lys Phe Pro Val 
            180                 185                 190         


Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Glu Asn Pro Gln Leu Lys 
        195                 200                 205             


Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Phe Thr Gly Ser 
    210                 215                 220                 


Val Ser Leu Leu Ile Leu Val Leu Asp Ala Asn Asp Asn Ala Pro Ile 
225                 230                 235                 240 


Phe Asp Arg Pro Val Tyr Glu Val Lys Met Tyr Glu Asn Gln Val Asn 
                245                 250                 255     


Gln Thr Leu Val Ile Arg Leu Asn Ala Ser Asp Ser Asp Glu Gly Ile 
            260                 265                 270         


Asn Lys Glu Met Met Tyr Ser Phe Ser Ser Leu Val Pro Pro Thr Ile 
        275                 280                 285             


Arg Arg Lys Phe Trp Ile Asn Glu Arg Thr Gly Glu Ile Lys Val Asn 
    290                 295                 300                 


Asp Ala Ile Asp Phe Glu Asp Ser Asn Thr Tyr Glu Ile His Val Asp 
305                 310                 315                 320 


Val Thr Asp Lys Gly Asn Pro Pro Met Val Gly His Cys Thr Val Leu 
                325                 330                 335     


Val Glu Leu Leu Asp Glu Asn Asp Asn Ser Pro Glu Val Ile Val Thr 
            340                 345                 350         


Ser Leu Ser Leu Pro Val Lys Glu Asp Ala Gln Val Gly Thr Val Ile 
        355                 360                 365             


Ala Leu Ile Ser Val Ser Asp His Asp Ser Gly Ala Asn Gly Gln Val 
    370                 375                 380                 


Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr Tyr 
385                 390                 395                 400 


Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu Arg 
                405                 410                 415     


Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser Pro 
            420                 425                 430         


Pro Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Ala Phe Ala Gln Ser Glu Tyr Thr Val Phe Val Lys 
    450                 455                 460                 


Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp Asp 
465                 470                 475                 480 


Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu Arg 
                485                 490                 495     


Arg Leu Gly Glu Arg Ser Leu Ser Ser Tyr Val Ser Val His Ala Glu 
            500                 505                 510         


Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu Glu 
        515                 520                 525             


Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Gly Gly Val Pro Pro Leu 
    530                 535                 540                 


Gly Ser Asn Leu Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Leu Leu Ala Ser Pro Ala Gly Ser Ala Gly Gly Ala Val 
                565                 570                 575     


Ser Glu Leu Val Leu Arg Ser Val Val Ala Gly His Val Val Ala Lys 
            580                 585                 590         


Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Glu Leu Gln Ser Ala Ala Val Gly Ala Arg Ile Pro Phe Arg Val Gly 
    610                 615                 620                 


Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr Asp 
625                 630                 635                 640 


Ser Pro Arg Gln Arg Leu Leu Val Leu Val Lys Asp His Gly Glu Pro 
                645                 650                 655     


Ser Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Gly Ser 
            660                 665                 670         


Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Val Gly Val Ala Pro Glu 
        675                 680                 685             


Val Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile Cys Ala 
    690                 695                 700                 


Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala Leu Arg 
705                 710                 715                 720 


Cys Ser Ala Ala Pro Thr Glu Gly Ala Cys Gly Pro Val Lys Pro Thr 
                725                 730                 735     


Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln Gln Arg 
            740                 745                 750         


Arg Gln Arg Val Cys Ser Gly Glu Gly Leu Pro Lys Ala Asp Leu Met 
        755                 760                 765             


Ala Phe Ser Pro Ser Leu Pro Pro Cys Pro Met Val Asp Val Asp Gly 
    770                 775                 780                 


Glu Asp Gln Ser Ile Gly Gly Asp His Ser Arg Lys Pro Arg Gln Pro 
785                 790                 795                 800 


Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser 
                805                 810                 815     


Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly 
            820                 825                 830         


Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu 
        835                 840                 845             


Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser 
    850                 855                 860                 


Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly 
865                 870                 875                 880 


Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser 
                885                 890                 895     


Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile 
            900                 905                 910         


Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp 
    930                 935                 940                 


Asn Ser Asp Gln 
945             


<210>  4501
<211>  1007
<212>  PRT
<213>  Homo sapiens

<400>  4501

Met Glu Gln Ala Gly Thr Arg Pro Ala Ala Thr Glu His Pro Arg Leu 
1               5                   10                  15      


Arg Arg Pro Met Pro Trp Leu Leu Leu Leu Pro Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Pro Gly Pro Ala Ala Ser Gln Leu Arg Tyr Ser Val 
        35                  40                  45              


Pro Glu Glu Gln Ala Pro Gly Ala Leu Val Gly Asn Val Ala Arg Ala 
    50                  55                  60                  


Leu Gly Leu Glu Leu Arg Arg Leu Gly Pro Gly Cys Leu Arg Ile Asn 
65                  70                  75                  80  


His Leu Gly Ala Pro Ser Pro Arg Tyr Leu Glu Leu Asp Leu Thr Ser 
                85                  90                  95      


Gly Ala Leu Phe Val Asn Glu Arg Ile Asp Arg Glu Ala Leu Cys Glu 
            100                 105                 110         


Gln Arg Pro Arg Cys Leu Leu Ser Leu Glu Val Leu Ala His Asn Pro 
        115                 120                 125             


Val Ala Val Ser Ala Val Glu Val Glu Ile Leu Asp Ile Asn Asp Asn 
    130                 135                 140                 


Ser Pro Arg Phe Pro Arg Pro Asn Tyr Gln Leu Gln Val Ser Glu Ser 
145                 150                 155                 160 


Val Ala Pro Gly Ala Arg Phe His Ile Glu Ser Ala Gln Asp Pro Asp 
                165                 170                 175     


Val Gly Ala Asn Ser Val Gln Thr Tyr Glu Leu Ser Pro Ser Glu His 
            180                 185                 190         


Phe Glu Leu Asp Leu Lys Pro Leu Gln Glu Asn Ser Lys Val Leu Glu 
        195                 200                 205             


Leu Val Leu Arg Lys Gly Leu Asp Arg Glu Gln Ala Ala Leu His His 
    210                 215                 220                 


Leu Val Leu Thr Ala Val Asp Gly Gly Ile Pro Ala Arg Ser Gly Thr 
225                 230                 235                 240 


Ala Gln Ile Ser Val Arg Val Leu Asp Thr Asn Asp Asn Ser Pro Ala 
                245                 250                 255     


Phe Asp Gln Ser Thr Tyr Arg Val Gln Leu Arg Glu Asp Ser Pro Pro 
            260                 265                 270         


Gly Thr Leu Val Val Lys Leu Asn Ala Ser Asp Pro Asp Glu Gly Ser 
        275                 280                 285             


Asn Gly Glu Leu Arg Tyr Ser Leu Ser Ser Tyr Thr Ser Asp Arg Glu 
    290                 295                 300                 


Arg Gln Leu Phe Ser Ile Asp Ala Ser Thr Gly Glu Val Arg Val Ile 
305                 310                 315                 320 


Gly Gly Leu Asp Tyr Glu Glu Ala Ser Ser Tyr Gln Ile Tyr Val Gln 
                325                 330                 335     


Ala Thr Asp Arg Gly Pro Val Pro Met Ala Gly His Cys Lys Val Leu 
            340                 345                 350         


Val Asp Ile Val Asp Val Asn Asp Asn Ala Pro Glu Val Val Leu Thr 
        355                 360                 365             


Asp Leu Tyr Ser Pro Val Pro Glu Asn Ala Thr Pro Asn Thr Ile Val 
    370                 375                 380                 


Ala Val Leu Ser Val Asn Asp Gln Asp Ser Gly Pro Asn Arg Lys Val 
385                 390                 395                 400 


Ser Leu Gly Leu Glu Ala Thr Leu Pro Phe Arg Leu Asn Gly Phe Gly 
                405                 410                 415     


Asn Ser Tyr Thr Leu Val Val Ser Gly Pro Leu Asp Arg Glu Arg Val 
            420                 425                 430         


Ala Val Tyr Asn Ile Thr Val Thr Ala Thr Asp Gly Gly Ile Pro Gln 
        435                 440                 445             


Leu Thr Ser Leu Arg Thr Leu Lys Val Glu Ile Ser Asp Ile Asn Asp 
    450                 455                 460                 


Asn Pro Pro Ser Phe Leu Glu Asp Ser Tyr Ser Ile Tyr Ile Gln Glu 
465                 470                 475                 480 


Asn Asn Leu Pro Gly Val Leu Leu Cys Thr Val Gln Ala Thr Asp Pro 
                485                 490                 495     


Asp Glu Lys Glu Asn Ala Glu Val Thr Tyr Ser Leu Leu Glu Arg Glu 
            500                 505                 510         


Ile Gln Gly Leu Pro Val Thr Ser Tyr Val Ser Ile Asn Ser Ala Ser 
        515                 520                 525             


Gly Ser Leu Tyr Ala Val Asn Ser Phe Asp Tyr Glu Lys Phe Arg Glu 
    530                 535                 540                 


Phe Phe Val Thr Val Glu Ala Gln Asp Lys Gly Ser Pro Pro Leu Ser 
545                 550                 555                 560 


Ser Thr Val Thr Ala Asn Val Tyr Val Val Asp Met Asn Asp His Ala 
                565                 570                 575     


Pro His Ile Leu Tyr Pro Thr Ser Thr Asn Ser Ser Ala Ala Phe Glu 
            580                 585                 590         


Met Val Pro Arg Thr Ala Pro Ala Gly Tyr Leu Val Thr Lys Val Ile 
        595                 600                 605             


Ala Met Asp Ser Asp Ser Gly Gln Asn Ala Trp Leu Phe Tyr His Leu 
    610                 615                 620                 


Ala Gln Thr Ser Asp Leu Asp Leu Phe Lys Val Glu Leu His Thr Gly 
625                 630                 635                 640 


Glu Ile Arg Thr Thr Arg Lys Met Gly Asp Glu Ser Gly Ser Thr Phe 
                645                 650                 655     


Asn Leu Thr Val Val Val Arg Asp Asn Gly Glu Pro Ser Leu Ser Ala 
            660                 665                 670         


Ser Val Ala Ile Thr Val Ala Val Val Asp Arg Val Ser Lys Ile Leu 
        675                 680                 685             


Pro Asp Thr Gln Arg His Val Lys Ser Pro Arg Thr Tyr Ser Glu Ile 
    690                 695                 700                 


Thr Leu Tyr Leu Ile Ile Ala Leu Ser Thr Val Ser Phe Ile Phe Leu 
705                 710                 715                 720 


Leu Thr Ile Ile Ile Leu Ser Ile Ile Lys Cys Tyr Arg Tyr Thr Ala 
                725                 730                 735     


Tyr Gly Thr Ala Cys Cys Gly Gly Phe Cys Gly Val Arg Glu Arg Ser 
            740                 745                 750         


Pro Ala Glu Leu Tyr Lys Gln Ala Asn Asn Asn Ile Asp Ala Arg Ile 
        755                 760                 765             


Pro His Gly Leu Lys Val Gln Pro His Phe Ile Glu Val Arg Gly Asn 
    770                 775                 780                 


Gly Ser Leu Thr Lys Thr Tyr Cys Tyr Lys Ala Cys Leu Thr Ala Gly 
785                 790                 795                 800 


Ser Gly Ser Asp Thr Phe Met Phe Tyr Asn Thr Gly Ala Gln Thr Gly 
                805                 810                 815     


Pro Gly Pro Ser Gly Ala Gln Ala Ala Val Thr Asp Ser Arg Asn Leu 
            820                 825                 830         


Thr Gly Gln Ser Gly Gln Asn Ala Gly Asn Leu Ile Ile Leu Lys Asn 
        835                 840                 845             


Glu Ala Val Ser Gln Asn Glu Pro Arg Gln Pro Asn Pro Asp Trp Arg 
    850                 855                 860                 


Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser Val His Leu Glu 
865                 870                 875                 880 


Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro Asp Gln Gln Trp 
                885                 890                 895     


Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala Gly Glu Val Ser 
            900                 905                 910         


Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr 
        915                 920                 925             


Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys 
    930                 935                 940                 


Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro 
945                 950                 955                 960 


Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys 
                965                 970                 975     


Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln 
            980                 985                 990         


Glu Lys Lys Glu Lys Gly Asn Ser  Thr Thr Asp Asn Ser  Asp Gln 
        995                 1000                 1005         


<210>  4502
<211>  1007
<212>  PRT
<213>  Homo sapiens

<400>  4502

Met Glu Gln Ala Gly Thr Arg Pro Ala Ala Thr Glu His Pro Arg Leu 
1               5                   10                  15      


Arg Arg Pro Met Pro Trp Leu Leu Leu Leu Pro Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Pro Gly Pro Ala Ala Ser Gln Leu Arg Tyr Ser Val 
        35                  40                  45              


Pro Glu Glu Gln Ala Pro Gly Ala Leu Val Gly Asn Val Ala Arg Ala 
    50                  55                  60                  


Leu Gly Leu Glu Leu Arg Arg Leu Gly Pro Gly Cys Leu Arg Ile Asn 
65                  70                  75                  80  


His Leu Gly Ala Pro Ser Pro Arg Tyr Leu Glu Leu Asp Leu Thr Ser 
                85                  90                  95      


Gly Ala Leu Phe Val Asn Glu Arg Ile Asp Arg Glu Ala Leu Cys Glu 
            100                 105                 110         


Gln Arg Pro Arg Cys Leu Leu Ser Leu Glu Val Leu Ala His Asn Pro 
        115                 120                 125             


Val Ala Val Ser Ala Val Glu Val Glu Ile Leu Asp Ile Asn Asp Asn 
    130                 135                 140                 


Ser Pro Arg Phe Pro Arg Pro Asn Tyr Gln Leu Gln Val Ser Glu Ser 
145                 150                 155                 160 


Val Ala Pro Gly Ala Arg Phe His Ile Glu Ser Ala Gln Asp Pro Asp 
                165                 170                 175     


Val Gly Ala Asn Ser Val Gln Thr Tyr Glu Leu Ser Pro Ser Glu His 
            180                 185                 190         


Phe Glu Leu Asp Leu Lys Pro Leu Gln Glu Asn Ser Lys Val Leu Glu 
        195                 200                 205             


Leu Val Leu Arg Lys Gly Leu Asp Arg Glu Gln Ala Ala Leu His His 
    210                 215                 220                 


Leu Val Leu Thr Ala Val Asp Gly Gly Ile Pro Ala Arg Ser Gly Thr 
225                 230                 235                 240 


Ala Gln Ile Ser Val Arg Val Leu Asp Thr Asn Asp Asn Ser Pro Ala 
                245                 250                 255     


Phe Asp Gln Ser Thr Tyr Arg Val Gln Leu Arg Glu Asp Ser Pro Pro 
            260                 265                 270         


Gly Thr Leu Val Val Lys Leu Asn Ala Ser Asp Pro Asp Glu Gly Ser 
        275                 280                 285             


Asn Gly Glu Leu Arg Tyr Ser Leu Ser Ser Tyr Thr Ser Asp Arg Glu 
    290                 295                 300                 


Arg Gln Leu Phe Ser Ile Asp Ala Ser Thr Gly Glu Val Arg Val Ile 
305                 310                 315                 320 


Gly Gly Leu Asp Tyr Glu Glu Ala Ser Ser Tyr Gln Ile Tyr Val Gln 
                325                 330                 335     


Ala Thr Asp Arg Gly Pro Val Pro Met Ala Gly His Cys Lys Val Leu 
            340                 345                 350         


Val Asp Ile Val Asp Val Asn Asp Asn Ala Pro Glu Val Val Leu Thr 
        355                 360                 365             


Asp Leu Tyr Ser Pro Val Pro Glu Asn Ala Thr Pro Asn Thr Ile Val 
    370                 375                 380                 


Ala Val Leu Ser Val Asn Asp Gln Asp Ser Gly Pro Asn Arg Lys Val 
385                 390                 395                 400 


Ser Leu Gly Leu Glu Ala Thr Leu Pro Phe Arg Leu Asn Gly Phe Gly 
                405                 410                 415     


Asn Ser Tyr Thr Leu Val Val Ser Gly Pro Leu Asp Arg Glu Arg Val 
            420                 425                 430         


Ala Val Tyr Asn Ile Thr Val Thr Ala Thr Asp Gly Gly Ile Pro Gln 
        435                 440                 445             


Leu Thr Ser Leu Arg Thr Leu Lys Val Glu Ile Ser Asp Ile Asn Asp 
    450                 455                 460                 


Asn Pro Pro Ser Phe Leu Glu Asp Ser Tyr Ser Ile Tyr Ile Gln Glu 
465                 470                 475                 480 


Asn Asn Leu Pro Gly Val Leu Leu Cys Thr Val Gln Ala Thr Asp Pro 
                485                 490                 495     


Asp Glu Lys Glu Asn Ala Glu Val Thr Tyr Ser Leu Leu Glu Arg Glu 
            500                 505                 510         


Ile Gln Gly Leu Pro Val Thr Ser Tyr Val Ser Ile Asn Ser Ala Ser 
        515                 520                 525             


Gly Ser Leu Tyr Ala Val Asn Ser Phe Asp Tyr Glu Lys Phe Arg Glu 
    530                 535                 540                 


Phe Phe Val Thr Val Glu Ala Gln Asp Lys Gly Ser Pro Pro Leu Ser 
545                 550                 555                 560 


Ser Thr Val Thr Ala Asn Val Tyr Val Val Asp Met Asn Asp His Ala 
                565                 570                 575     


Pro His Ile Leu Tyr Pro Thr Ser Thr Asn Ser Ser Ala Ala Phe Glu 
            580                 585                 590         


Met Val Pro Arg Thr Ala Pro Ala Gly Tyr Leu Val Thr Lys Val Ile 
        595                 600                 605             


Ala Met Asp Ser Asp Ser Gly Gln Asn Ala Trp Leu Phe Tyr His Leu 
    610                 615                 620                 


Ala Gln Thr Ser Asp Leu Asp Leu Phe Lys Val Glu Leu His Thr Gly 
625                 630                 635                 640 


Glu Ile Arg Thr Thr Arg Lys Met Gly Asp Glu Ser Gly Ser Thr Phe 
                645                 650                 655     


Asn Leu Thr Val Val Val Arg Asp Asn Gly Glu Pro Ser Leu Ser Ala 
            660                 665                 670         


Ser Val Ala Ile Thr Val Ala Val Val Asp Arg Val Ser Lys Ile Leu 
        675                 680                 685             


Pro Asp Thr Gln Arg His Val Lys Ser Pro Arg Thr Tyr Ser Glu Ile 
    690                 695                 700                 


Thr Leu Tyr Leu Ile Ile Ala Leu Ser Thr Val Ser Phe Ile Phe Leu 
705                 710                 715                 720 


Leu Thr Ile Ile Ile Leu Ser Ile Ile Lys Cys Tyr Arg Tyr Thr Ala 
                725                 730                 735     


Tyr Gly Thr Ala Cys Cys Gly Gly Phe Cys Gly Val Arg Glu Arg Ser 
            740                 745                 750         


Pro Ala Glu Leu Tyr Lys Gln Ala Asn Asn Asn Ile Asp Ala Arg Ile 
        755                 760                 765             


Pro His Gly Leu Lys Val Gln Pro His Phe Ile Glu Val Arg Gly Asn 
    770                 775                 780                 


Gly Ser Leu Thr Lys Thr Tyr Cys Tyr Lys Ala Cys Leu Thr Ala Gly 
785                 790                 795                 800 


Ser Gly Ser Asp Thr Phe Met Phe Tyr Asn Thr Gly Ala Gln Thr Gly 
                805                 810                 815     


Pro Gly Pro Ser Gly Ala Gln Ala Ala Val Thr Asp Ser Arg Asn Leu 
            820                 825                 830         


Thr Gly Gln Ser Gly Gln Asn Ala Gly Asn Leu Ile Ile Leu Lys Asn 
        835                 840                 845             


Glu Ala Val Ser Gln Asn Glu Pro Arg Gln Pro Asn Pro Asp Trp Arg 
    850                 855                 860                 


Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser Val His Leu Glu 
865                 870                 875                 880 


Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro Asp Gln Gln Trp 
                885                 890                 895     


Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala Gly Glu Val Ser 
            900                 905                 910         


Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr 
        915                 920                 925             


Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys 
    930                 935                 940                 


Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro 
945                 950                 955                 960 


Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys 
                965                 970                 975     


Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln 
            980                 985                 990         


Glu Lys Lys Glu Lys Gly Asn Ser  Thr Thr Asp Asn Ser  Asp Gln 
        995                 1000                 1005         


<210>  4503
<211>  948
<212>  PRT
<213>  Homo sapiens

<400>  4503

Met Val Ser Arg Cys Ser Cys Leu Gly Val Gln Cys Leu Leu Leu Ser 
1               5                   10                  15      


Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His Tyr 
            20                  25                  30          


Ser Val Tyr Glu Glu Ala Arg His Gly Thr Phe Val Gly Arg Ile Ala 
        35                  40                  45              


Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Gln Arg Leu Phe Arg 
    50                  55                  60                  


Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln Asn 
65                  70                  75                  80  


Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys Gly 
                85                  90                  95      


Arg Ser Val Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg Pro 
            100                 105                 110         


Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp Asn 
        115                 120                 125             


Pro Pro Arg Phe Ser Val Thr Glu Gln Lys Leu Ser Ile Pro Glu Ser 
    130                 135                 140                 


Arg Leu Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala Asp 
145                 150                 155                 160 


Val Gly Glu Asn Ala Leu Leu Thr Tyr Lys Leu Ser Pro Asn Glu Tyr 
                165                 170                 175     


Phe Val Leu Asp Ile Ile Asn Lys Lys Asp Lys Asp Lys Phe Pro Val 
            180                 185                 190         


Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Glu Asn Pro Gln Leu Lys 
        195                 200                 205             


Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Phe Thr Gly Ser 
    210                 215                 220                 


Val Ser Leu Leu Ile Leu Val Leu Asp Ala Asn Asp Asn Ala Pro Ile 
225                 230                 235                 240 


Phe Asp Arg Pro Val Tyr Glu Val Lys Met Tyr Glu Asn Gln Val Asn 
                245                 250                 255     


Gln Thr Leu Val Ile Arg Leu Asn Ala Ser Asp Ser Asp Glu Gly Ile 
            260                 265                 270         


Asn Lys Glu Met Met Tyr Ser Phe Ser Ser Leu Val Pro Pro Thr Ile 
        275                 280                 285             


Arg Arg Lys Phe Trp Ile Asn Glu Arg Thr Gly Glu Ile Lys Val Asn 
    290                 295                 300                 


Asp Ala Ile Asp Phe Glu Asp Ser Asn Thr Tyr Glu Ile His Val Asp 
305                 310                 315                 320 


Val Thr Asp Lys Gly Asn Pro Pro Met Val Gly His Cys Thr Val Leu 
                325                 330                 335     


Val Glu Leu Leu Asp Glu Asn Asp Asn Ser Pro Glu Val Ile Val Thr 
            340                 345                 350         


Ser Leu Ser Leu Pro Val Lys Glu Asp Ala Gln Val Gly Thr Val Ile 
        355                 360                 365             


Ala Leu Ile Ser Val Ser Asp His Asp Ser Gly Ala Asn Gly Gln Val 
    370                 375                 380                 


Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr Tyr 
385                 390                 395                 400 


Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu Arg 
                405                 410                 415     


Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser Pro 
            420                 425                 430         


Pro Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Ala Phe Ala Gln Ser Glu Tyr Thr Val Phe Val Lys 
    450                 455                 460                 


Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp Asp 
465                 470                 475                 480 


Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu Arg 
                485                 490                 495     


Arg Leu Gly Glu Arg Ser Leu Ser Ser Tyr Val Ser Val His Ala Glu 
            500                 505                 510         


Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu Glu 
        515                 520                 525             


Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Gly Gly Val Pro Pro Leu 
    530                 535                 540                 


Gly Ser Asn Leu Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Leu Leu Ala Ser Pro Ala Gly Ser Ala Gly Gly Ala Val 
                565                 570                 575     


Ser Glu Leu Val Leu Arg Ser Val Val Ala Gly His Val Val Ala Lys 
            580                 585                 590         


Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Glu Leu Gln Ser Ala Ala Val Gly Ala Arg Ile Pro Phe Arg Val Gly 
    610                 615                 620                 


Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr Asp 
625                 630                 635                 640 


Ser Pro Arg Gln Arg Leu Leu Val Leu Val Lys Asp His Gly Glu Pro 
                645                 650                 655     


Ser Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Gly Ser 
            660                 665                 670         


Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Val Gly Val Ala Pro Glu 
        675                 680                 685             


Val Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile Cys Ala 
    690                 695                 700                 


Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala Leu Arg 
705                 710                 715                 720 


Cys Ser Ala Ala Pro Thr Glu Gly Ala Cys Gly Pro Val Lys Pro Thr 
                725                 730                 735     


Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln Gln Arg 
            740                 745                 750         


Arg Gln Arg Val Cys Ser Gly Glu Gly Leu Pro Lys Ala Asp Leu Met 
        755                 760                 765             


Ala Phe Ser Pro Ser Leu Pro Pro Cys Pro Met Val Asp Val Asp Gly 
    770                 775                 780                 


Glu Asp Gln Ser Ile Gly Gly Asp His Ser Arg Lys Pro Arg Gln Pro 
785                 790                 795                 800 


Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser 
                805                 810                 815     


Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly 
            820                 825                 830         


Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu 
        835                 840                 845             


Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser 
    850                 855                 860                 


Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly 
865                 870                 875                 880 


Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser 
                885                 890                 895     


Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile 
            900                 905                 910         


Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp 
    930                 935                 940                 


Asn Ser Asp Gln 
945             


<210>  4504
<211>  1007
<212>  PRT
<213>  Homo sapiens

<400>  4504

Met Glu Gln Ala Gly Thr Arg Pro Ala Ala Thr Glu His Pro Arg Leu 
1               5                   10                  15      


Arg Arg Pro Met Pro Trp Leu Leu Leu Leu Pro Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Pro Gly Pro Ala Ala Ser Gln Leu Arg Tyr Ser Val 
        35                  40                  45              


Pro Glu Glu Gln Ala Pro Gly Ala Leu Val Gly Asn Val Ala Arg Ala 
    50                  55                  60                  


Leu Gly Leu Glu Leu Arg Arg Leu Gly Pro Gly Cys Leu Arg Ile Asn 
65                  70                  75                  80  


His Leu Gly Ala Pro Ser Pro Arg Tyr Leu Glu Leu Asp Leu Thr Ser 
                85                  90                  95      


Gly Ala Leu Phe Val Asn Glu Arg Ile Asp Arg Glu Ala Leu Cys Glu 
            100                 105                 110         


Gln Arg Pro Arg Cys Leu Leu Ser Leu Glu Val Leu Ala His Asn Pro 
        115                 120                 125             


Val Ala Val Ser Ala Val Glu Val Glu Ile Leu Asp Ile Asn Asp Asn 
    130                 135                 140                 


Ser Pro Arg Phe Pro Arg Pro Asn Tyr Gln Leu Gln Val Ser Glu Ser 
145                 150                 155                 160 


Val Ala Pro Gly Ala Arg Phe His Ile Glu Ser Ala Gln Asp Pro Asp 
                165                 170                 175     


Val Gly Ala Asn Ser Val Gln Thr Tyr Glu Leu Ser Pro Ser Glu His 
            180                 185                 190         


Phe Glu Leu Asp Leu Lys Pro Leu Gln Glu Asn Ser Lys Val Leu Glu 
        195                 200                 205             


Leu Val Leu Arg Lys Gly Leu Asp Arg Glu Gln Ala Ala Leu His His 
    210                 215                 220                 


Leu Val Leu Thr Ala Val Asp Gly Gly Ile Pro Ala Arg Ser Gly Thr 
225                 230                 235                 240 


Ala Gln Ile Ser Val Arg Val Leu Asp Thr Asn Asp Asn Ser Pro Ala 
                245                 250                 255     


Phe Asp Gln Ser Thr Tyr Arg Val Gln Leu Arg Glu Asp Ser Pro Pro 
            260                 265                 270         


Gly Thr Leu Val Val Lys Leu Asn Ala Ser Asp Pro Asp Glu Gly Ser 
        275                 280                 285             


Asn Gly Glu Leu Arg Tyr Ser Leu Ser Ser Tyr Thr Ser Asp Arg Glu 
    290                 295                 300                 


Arg Gln Leu Phe Ser Ile Asp Ala Ser Thr Gly Glu Val Arg Val Ile 
305                 310                 315                 320 


Gly Gly Leu Asp Tyr Glu Glu Ala Ser Ser Tyr Gln Ile Tyr Val Gln 
                325                 330                 335     


Ala Thr Asp Arg Gly Pro Val Pro Met Ala Gly His Cys Lys Val Leu 
            340                 345                 350         


Val Asp Ile Val Asp Val Asn Asp Asn Ala Pro Glu Val Val Leu Thr 
        355                 360                 365             


Asp Leu Tyr Ser Pro Val Pro Glu Asn Ala Thr Pro Asn Thr Ile Val 
    370                 375                 380                 


Ala Val Leu Ser Val Asn Asp Gln Asp Ser Gly Pro Asn Arg Lys Val 
385                 390                 395                 400 


Ser Leu Gly Leu Glu Ala Thr Leu Pro Phe Arg Leu Asn Gly Phe Gly 
                405                 410                 415     


Asn Ser Tyr Thr Leu Val Val Ser Gly Pro Leu Asp Arg Glu Arg Val 
            420                 425                 430         


Ala Val Tyr Asn Ile Thr Val Thr Ala Thr Asp Gly Gly Ile Pro Gln 
        435                 440                 445             


Leu Thr Ser Leu Arg Thr Leu Lys Val Glu Ile Ser Asp Ile Asn Asp 
    450                 455                 460                 


Asn Pro Pro Ser Phe Leu Glu Asp Ser Tyr Ser Ile Tyr Ile Gln Glu 
465                 470                 475                 480 


Asn Asn Leu Pro Gly Val Leu Leu Cys Thr Val Gln Ala Thr Asp Pro 
                485                 490                 495     


Asp Glu Lys Glu Asn Ala Glu Val Thr Tyr Ser Leu Leu Glu Arg Glu 
            500                 505                 510         


Ile Gln Gly Leu Pro Val Thr Ser Tyr Val Ser Ile Asn Ser Ala Ser 
        515                 520                 525             


Gly Ser Leu Tyr Ala Val Asn Ser Phe Asp Tyr Glu Lys Phe Arg Glu 
    530                 535                 540                 


Phe Phe Val Thr Val Glu Ala Gln Asp Lys Gly Ser Pro Pro Leu Ser 
545                 550                 555                 560 


Ser Thr Val Thr Ala Asn Val Tyr Val Val Asp Met Asn Asp His Ala 
                565                 570                 575     


Pro His Ile Leu Tyr Pro Thr Ser Thr Asn Ser Ser Ala Ala Phe Glu 
            580                 585                 590         


Met Val Pro Arg Thr Ala Pro Ala Gly Tyr Leu Val Thr Lys Val Ile 
        595                 600                 605             


Ala Met Asp Ser Asp Ser Gly Gln Asn Ala Trp Leu Phe Tyr His Leu 
    610                 615                 620                 


Ala Gln Thr Ser Asp Leu Asp Leu Phe Lys Val Glu Leu His Thr Gly 
625                 630                 635                 640 


Glu Ile Arg Thr Thr Arg Lys Met Gly Asp Glu Ser Gly Ser Thr Phe 
                645                 650                 655     


Asn Leu Thr Val Val Val Arg Asp Asn Gly Glu Pro Ser Leu Ser Ala 
            660                 665                 670         


Ser Val Ala Ile Thr Val Ala Val Val Asp Arg Val Ser Lys Ile Leu 
        675                 680                 685             


Pro Asp Thr Gln Arg His Val Lys Ser Pro Arg Thr Tyr Ser Glu Ile 
    690                 695                 700                 


Thr Leu Tyr Leu Ile Ile Ala Leu Ser Thr Val Ser Phe Ile Phe Leu 
705                 710                 715                 720 


Leu Thr Ile Ile Ile Leu Ser Ile Ile Lys Cys Tyr Arg Tyr Thr Ala 
                725                 730                 735     


Tyr Gly Thr Ala Cys Cys Gly Gly Phe Cys Gly Val Arg Glu Arg Ser 
            740                 745                 750         


Pro Ala Glu Leu Tyr Lys Gln Ala Asn Asn Asn Ile Asp Ala Arg Ile 
        755                 760                 765             


Pro His Gly Leu Lys Val Gln Pro His Phe Ile Glu Val Arg Gly Asn 
    770                 775                 780                 


Gly Ser Leu Thr Lys Thr Tyr Cys Tyr Lys Ala Cys Leu Thr Ala Gly 
785                 790                 795                 800 


Ser Gly Ser Asp Thr Phe Met Phe Tyr Asn Thr Gly Ala Gln Thr Gly 
                805                 810                 815     


Pro Gly Pro Ser Gly Ala Gln Ala Ala Val Thr Asp Ser Arg Asn Leu 
            820                 825                 830         


Thr Gly Gln Ser Gly Gln Asn Ala Gly Asn Leu Ile Ile Leu Lys Asn 
        835                 840                 845             


Glu Ala Val Ser Gln Asn Glu Pro Arg Gln Pro Asn Pro Asp Trp Arg 
    850                 855                 860                 


Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser Val His Leu Glu 
865                 870                 875                 880 


Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro Asp Gln Gln Trp 
                885                 890                 895     


Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala Gly Glu Val Ser 
            900                 905                 910         


Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr 
        915                 920                 925             


Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys 
    930                 935                 940                 


Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro 
945                 950                 955                 960 


Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys 
                965                 970                 975     


Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln 
            980                 985                 990         


Glu Lys Lys Glu Lys Gly Asn Ser  Thr Thr Asp Asn Ser  Asp Gln 
        995                 1000                 1005         


<210>  4505
<211>  963
<212>  PRT
<213>  Homo sapiens

<400>  4505

Met Val Gly Cys Gly Val Ala Val Leu Cys Leu Trp Val Ser Cys Gly 
1               5                   10                  15      


Ala Ala Ala Gly Gln Leu Glu Tyr Ser Val Pro Glu Glu Thr Glu Arg 
            20                  25                  30          


Gly Val Ala Val Gly Asn Leu Ser Ala Asp Leu Arg Leu Pro Ala Ala 
        35                  40                  45              


Ala Met Ser Ser Arg Asn Phe Arg Phe Leu Ser Ser His Arg Glu Leu 
    50                  55                  60                  


Tyr Phe Gly Val Asp Leu Pro Ser Gly Asn Leu Val Val Arg Glu Pro 
65                  70                  75                  80  


Ala Asp Arg Glu Gln Leu Cys Arg Ala Lys Ala Ala Cys Val Leu Thr 
                85                  90                  95      


Tyr Asp Leu Val Leu Glu Asp Pro Leu Glu Leu His Lys Ile Arg Ile 
            100                 105                 110         


His Val Leu Asp Thr Asn Asp Asn Ser Pro Leu Phe Pro Ala Gly Asp 
        115                 120                 125             


Val Gln Leu His Ile Pro Glu Phe Leu Thr Pro Gly Ala Arg Phe Thr 
    130                 135                 140                 


Leu Pro Asn Ala Gln Asp Asp Asp Glu Gly Ser Asn Gly Ile Leu Ser 
145                 150                 155                 160 


Tyr Ser Leu Ser Pro Ser Gln His Phe Arg Leu Asp Met Gly Ser Arg 
                165                 170                 175     


Val Asp Gly Ser Glu Tyr Pro Glu Leu Val Leu Glu Lys Ala Leu Asp 
            180                 185                 190         


Arg Glu Gln Arg Ala Thr His Leu Leu Val Leu Thr Ala Arg Asp Gly 
        195                 200                 205             


Gly Leu Pro Ala Arg Ser Gly Asp Ala Gln Val Thr Ile Ile Val Val 
    210                 215                 220                 


Asp Thr Asn Asp Asn Ala Pro Val Phe Glu Arg Ser Val Tyr Arg Thr 
225                 230                 235                 240 


Lys Val Pro Glu Thr Ala Pro Asn Gly Thr Val Leu Phe Arg Val Gln 
                245                 250                 255     


Ala Leu Asp Pro Asp Glu Gly Ser Asn Gly Glu Val Gln Tyr Ser Leu 
            260                 265                 270         


Ser Asn Ser Thr Gln Ala Glu Leu Arg His Arg Phe His Val His Pro 
        275                 280                 285             


Lys Ser Gly Glu Val Gln Val Ala Ala Ser Leu Gly Pro Pro Glu Thr 
    290                 295                 300                 


Leu Leu Glu Ala Tyr Ile Glu Ala Arg Asp Glu Gly Val Phe Gly Leu 
305                 310                 315                 320 


Ala Ser Thr Ala Lys Leu Leu Val Glu Val Thr Asp Val Asn Asp His 
                325                 330                 335     


Ala Pro Glu Leu Asp Phe Leu Thr Leu Ser Asn Pro Val Pro Glu Asp 
            340                 345                 350         


Ala Ala Pro Gly Thr Val Ile Ala Leu Phe Ser Val Lys Asp Glu Asp 
        355                 360                 365             


Leu Asp Ser Asn Gly Arg Val Ile Cys Gly Met Ser Ser Ala Gly Pro 
    370                 375                 380                 


Phe Gln Leu Thr Ala Ser Phe Asp Asn Tyr Tyr Ser Leu Leu Ile Asp 
385                 390                 395                 400 


Gly Pro Leu Asp Arg Glu Gln Ile Ser Glu Tyr Gln Val Leu Ile Thr 
                405                 410                 415     


Ala Ser Asp Ser Gly Ser Pro Pro Leu Ser Thr Arg Arg Thr Ile Thr 
            420                 425                 430         


Val Ser Val Ala Asp Val Asn Asp Asn Thr Pro Asn Phe Pro Gln Pro 
        435                 440                 445             


Gln Gln Glu Leu Phe Val Ala Glu Asn Asn Gly Pro Gly Ala Ser Leu 
    450                 455                 460                 


Gly Arg Val Phe Ala Gln Asp Pro Asp Leu Gly Lys Asn Gly Leu Val 
465                 470                 475                 480 


Ser Tyr Glu Leu Leu Asp Val Ile Ser Glu Gly Pro Ser Ala Ser Ser 
                485                 490                 495     


Leu Leu Ala Val Glu Ser Ser Ser Gly Ala Ile Thr Ala Lys Thr Ser 
            500                 505                 510         


Phe Asp Phe Glu Gln Leu Arg Gly Phe His Phe Gln Val Glu Gly Arg 
        515                 520                 525             


Asp Gly Gly Ile Pro Pro Arg Ser Ala Thr Val Thr Ile Asn Leu Phe 
    530                 535                 540                 


Val Val Asp Arg Asn Asp Asn Tyr Pro Val Ile Leu Phe Pro Leu Pro 
545                 550                 555                 560 


Arg Asn Gly Ser Val Pro Val Glu Ile Val Pro Arg Ser Ala Arg Thr 
                565                 570                 575     


Gly His Leu Val Thr Lys Val Val Ala Glu Asp Ala Asp Ser Gly Ser 
            580                 585                 590         


Asn Ala Trp Leu Ser Tyr His Ile Ser Arg Ala Ser Asp Ser Ser Leu 
        595                 600                 605             


Phe Arg Ile Ser Ala Asn Ile Gly Glu Leu Arg Thr Ala Arg Leu Val 
    610                 615                 620                 


Leu Pro Thr Asp Ala Val Lys Gln Arg Val Val Val Val Val Arg Asp 
625                 630                 635                 640 


His Gly Asp Pro Pro Leu Ser Ser Ser Val Thr Leu Gly Val Leu Leu 
                645                 650                 655     


Ser Asn Ser Val Pro Gln Leu Leu Pro Asp Phe Glu Asp Val Trp Glu 
            660                 665                 670         


Pro Gly Gly Gln Leu Ser Ala Gln Asn Leu Tyr Leu Val Ile Ala Leu 
        675                 680                 685             


Ala Cys Ile Ser Phe Leu Phe Leu Gly Cys Leu Leu Phe Phe Val Cys 
    690                 695                 700                 


Thr Lys Leu His Gln Ser Pro Gly Cys Cys Ala Gln Ser Cys Cys Arg 
705                 710                 715                 720 


Ser Thr Glu Asp Leu Arg Tyr Gly Ser Lys Met Val Ser Asn Pro Cys 
                725                 730                 735     


Met Thr Ser Ala Thr Ile Asp Val Thr Thr Val Glu Arg Leu Ser Gln 
            740                 745                 750         


Thr Tyr Leu Tyr Arg Ala Ser Leu Gly Leu Gly Ser Asp Asn Asn Ser 
        755                 760                 765             


Leu Leu Leu Arg Gly Glu Tyr Asn Ala Ala Asp Leu Arg Asn Leu Ala 
    770                 775                 780                 


Thr Gly Val Gly Leu Asn Leu Pro Ile Ser Cys Ile Gln Ile Arg Asn 
785                 790                 795                 800 


Arg Lys Gly Asp His Ala Asn Val Asn Ala Met Pro Arg Gln Pro Asn 
                805                 810                 815     


Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser 
            820                 825                 830         


Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro 
        835                 840                 845             


Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala 
    850                 855                 860                 


Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp 
865                 870                 875                 880 


Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu 
                885                 890                 895     


Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile 
            900                 905                 910         


Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr 
        915                 920                 925             


Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly 
    930                 935                 940                 


Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn 
945                 950                 955                 960 


Ser Asp Gln 
            


<210>  4506
<211>  950
<212>  PRT
<213>  Homo sapiens

<400>  4506

Met Leu Ser Ser Trp Gln Gly Gly Pro Arg Pro Arg Gln Leu Leu Leu 
1               5                   10                  15      


Trp Leu Leu Ile Leu Ala Ala Trp Glu Thr Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Glu Val Lys Val Arg Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Ile Phe Pro Glu Ser Lys Lys Arg Ile Ile Ile Ala Glu 
    130                 135                 140                 


Ser Arg Pro Pro Glu Thr Arg Phe Pro Leu Asp Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Val Asn Ser Ala Leu Thr Tyr Arg Leu Asp Pro Asn Asp 
                165                 170                 175     


Tyr Phe Thr Leu Asp Ala Gln Asn Ser Leu Glu Gln Met Ser Ser Leu 
            180                 185                 190         


Ser Leu Val Leu Arg Lys Thr Leu Asp Arg Glu Glu Ile Gln Glu His 
        195                 200                 205             


Ser Leu Leu Leu Thr Ala Ser Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Ile Thr Ile Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Glu Phe Tyr Gln Ser Val Tyr Lys Val Thr Val Leu Glu Asn Ala Phe 
                245                 250                 255     


Asn Gly Thr Leu Val Ile Lys Leu Asn Ala Thr Asp Pro Asp Asp Gly 
            260                 265                 270         


Thr Asn Gly Asp Ile Val Tyr Ser Phe Arg Arg Pro Val Trp Pro Ala 
        275                 280                 285             


Val Val Tyr Ala Phe Thr Ile Asn Pro Asn Asn Gly Glu Ile Arg Thr 
    290                 295                 300                 


Lys Gly Lys Leu Asp Phe Glu Glu Lys Lys Leu Tyr Glu Ile Ser Val 
305                 310                 315                 320 


Glu Ala Val Asp Lys Gly Asn Ile Pro Met Ala Gly His Cys Thr Leu 
                325                 330                 335     


Leu Val Glu Val Leu Asp Val Asn Asp Asn Ala Pro Glu Val Thr Ile 
            340                 345                 350         


Thr Ser Leu Ser Leu Pro Ile Arg Glu Asp Thr Gln Pro Ser Ala Ile 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Ser Asp Arg Asp Ser Gly Ser Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Thr Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Tyr Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Val Ser Val Gly Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Gln 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ser Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Thr Pro Gly Ala Gly Ser Ala Gly Gly Thr 
                565                 570                 575     


Val Ser Glu Leu Met Pro Arg Ser Val Gly Ala Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Leu Ala Ala Val Gly Ala Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Pro Leu Asp Glu Val 
625                 630                 635                 640 


Asp Ala Pro His His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Leu Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Gln Ala Ser Ser Arg Ala Ser Ala Gly Ala Val Gly 
        675                 680                 685             


Pro Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Pro Pro Thr Glu Gly Ala Cys Ala Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Ala Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Pro Arg Val Cys Ser Gly Glu Gly Pro His Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Pro Pro Cys Leu Gly Ser Ala Glu 
    770                 775                 780                 


Gly Thr Gly Gln Arg Glu Glu Asp Ser Glu Cys Leu Lys Glu Pro Arg 
785                 790                 795                 800 


Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met 
                805                 810                 815     


His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro 
            820                 825                 830         


Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu 
        835                 840                 845             


Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser 
    850                 855                 860                 


Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly 
865                 870                 875                 880 


Pro Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile 
                885                 890                 895     


Ile Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp 
            900                 905                 910         


Phe Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Lys Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr 
    930                 935                 940                 


Thr Asp Asn Ser Asp Gln 
945                 950 


<210>  4507
<211>  948
<212>  PRT
<213>  Homo sapiens

<400>  4507

Met Val Ser Arg Cys Ser Cys Leu Gly Val Gln Cys Leu Leu Leu Ser 
1               5                   10                  15      


Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His Tyr 
            20                  25                  30          


Ser Val Tyr Glu Glu Ala Arg His Gly Thr Phe Val Gly Arg Ile Ala 
        35                  40                  45              


Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Gln Arg Leu Phe Arg 
    50                  55                  60                  


Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln Asn 
65                  70                  75                  80  


Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys Gly 
                85                  90                  95      


Arg Ser Val Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg Pro 
            100                 105                 110         


Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp Asn 
        115                 120                 125             


Pro Pro Arg Phe Ser Val Thr Glu Gln Lys Leu Ser Ile Pro Glu Ser 
    130                 135                 140                 


Arg Leu Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala Asp 
145                 150                 155                 160 


Val Gly Glu Asn Ala Leu Leu Thr Tyr Lys Leu Ser Pro Asn Glu Tyr 
                165                 170                 175     


Phe Val Leu Asp Ile Ile Asn Lys Lys Asp Lys Asp Lys Phe Pro Val 
            180                 185                 190         


Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Glu Asn Pro Gln Leu Lys 
        195                 200                 205             


Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Phe Thr Gly Ser 
    210                 215                 220                 


Val Ser Leu Leu Ile Leu Val Leu Asp Ala Asn Asp Asn Ala Pro Ile 
225                 230                 235                 240 


Phe Asp Arg Pro Val Tyr Glu Val Lys Met Tyr Glu Asn Gln Val Asn 
                245                 250                 255     


Gln Thr Leu Val Ile Arg Leu Asn Ala Ser Asp Ser Asp Glu Gly Ile 
            260                 265                 270         


Asn Lys Glu Met Met Tyr Ser Phe Ser Ser Leu Val Pro Pro Thr Ile 
        275                 280                 285             


Arg Arg Lys Phe Trp Ile Asn Glu Arg Thr Gly Glu Ile Lys Val Asn 
    290                 295                 300                 


Asp Ala Ile Asp Phe Glu Asp Ser Asn Thr Tyr Glu Ile His Val Asp 
305                 310                 315                 320 


Val Thr Asp Lys Gly Asn Pro Pro Met Val Gly His Cys Thr Val Leu 
                325                 330                 335     


Val Glu Leu Leu Asp Glu Asn Asp Asn Ser Pro Glu Val Ile Val Thr 
            340                 345                 350         


Ser Leu Ser Leu Pro Val Lys Glu Asp Ala Gln Val Gly Thr Val Ile 
        355                 360                 365             


Ala Leu Ile Ser Val Ser Asp His Asp Ser Gly Ala Asn Gly Gln Val 
    370                 375                 380                 


Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr Tyr 
385                 390                 395                 400 


Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu Arg 
                405                 410                 415     


Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser Pro 
            420                 425                 430         


Pro Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Ala Phe Ala Gln Ser Glu Tyr Thr Val Phe Val Lys 
    450                 455                 460                 


Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp Asp 
465                 470                 475                 480 


Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu Arg 
                485                 490                 495     


Arg Leu Gly Glu Arg Ser Leu Ser Ser Tyr Val Ser Val His Ala Glu 
            500                 505                 510         


Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu Glu 
        515                 520                 525             


Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Gly Gly Val Pro Pro Leu 
    530                 535                 540                 


Gly Ser Asn Leu Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Leu Leu Ala Ser Pro Ala Gly Ser Ala Gly Gly Ala Val 
                565                 570                 575     


Ser Glu Leu Val Leu Arg Ser Val Val Ala Gly His Val Val Ala Lys 
            580                 585                 590         


Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Glu Leu Gln Ser Ala Ala Val Gly Ala Arg Ile Pro Phe Arg Val Gly 
    610                 615                 620                 


Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr Asp 
625                 630                 635                 640 


Ser Pro Arg Gln Arg Leu Leu Val Leu Val Lys Asp His Gly Glu Pro 
                645                 650                 655     


Ser Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Gly Ser 
            660                 665                 670         


Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Val Gly Val Ala Pro Glu 
        675                 680                 685             


Val Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile Cys Ala 
    690                 695                 700                 


Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala Leu Arg 
705                 710                 715                 720 


Cys Ser Ala Ala Pro Thr Glu Gly Ala Cys Gly Pro Val Lys Pro Thr 
                725                 730                 735     


Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln Gln Arg 
            740                 745                 750         


Arg Gln Arg Val Cys Ser Gly Glu Gly Leu Pro Lys Ala Asp Leu Met 
        755                 760                 765             


Ala Phe Ser Pro Ser Leu Pro Pro Cys Pro Met Val Asp Val Asp Gly 
    770                 775                 780                 


Glu Asp Gln Ser Ile Gly Gly Asp His Ser Arg Lys Pro Arg Gln Pro 
785                 790                 795                 800 


Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser 
                805                 810                 815     


Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly 
            820                 825                 830         


Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu 
        835                 840                 845             


Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser 
    850                 855                 860                 


Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly 
865                 870                 875                 880 


Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser 
                885                 890                 895     


Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile 
            900                 905                 910         


Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp 
    930                 935                 940                 


Asn Ser Asp Gln 
945             


<210>  4508
<211>  963
<212>  PRT
<213>  Homo sapiens

<400>  4508

Met Val Gly Cys Gly Val Ala Val Leu Cys Leu Trp Val Ser Cys Gly 
1               5                   10                  15      


Ala Ala Ala Gly Gln Leu Glu Tyr Ser Val Pro Glu Glu Thr Glu Arg 
            20                  25                  30          


Gly Val Ala Val Gly Asn Leu Ser Ala Asp Leu Arg Leu Pro Ala Ala 
        35                  40                  45              


Ala Met Ser Ser Arg Asn Phe Arg Phe Leu Ser Ser His Arg Glu Leu 
    50                  55                  60                  


Tyr Phe Gly Val Asp Leu Pro Ser Gly Asn Leu Val Val Arg Glu Pro 
65                  70                  75                  80  


Ala Asp Arg Glu Gln Leu Cys Arg Ala Lys Ala Ala Cys Val Leu Thr 
                85                  90                  95      


Tyr Asp Leu Val Leu Glu Asp Pro Leu Glu Leu His Lys Ile Arg Ile 
            100                 105                 110         


His Val Leu Asp Thr Asn Asp Asn Ser Pro Leu Phe Pro Ala Gly Asp 
        115                 120                 125             


Val Gln Leu His Ile Pro Glu Phe Leu Thr Pro Gly Ala Arg Phe Thr 
    130                 135                 140                 


Leu Pro Asn Ala Gln Asp Asp Asp Glu Gly Ser Asn Gly Ile Leu Ser 
145                 150                 155                 160 


Tyr Ser Leu Ser Pro Ser Gln His Phe Arg Leu Asp Met Gly Ser Arg 
                165                 170                 175     


Val Asp Gly Ser Glu Tyr Pro Glu Leu Val Leu Glu Lys Ala Leu Asp 
            180                 185                 190         


Arg Glu Gln Arg Ala Thr His Leu Leu Val Leu Thr Ala Arg Asp Gly 
        195                 200                 205             


Gly Leu Pro Ala Arg Ser Gly Asp Ala Gln Val Thr Ile Ile Val Val 
    210                 215                 220                 


Asp Thr Asn Asp Asn Ala Pro Val Phe Glu Arg Ser Val Tyr Arg Thr 
225                 230                 235                 240 


Lys Val Pro Glu Thr Ala Pro Asn Gly Thr Val Leu Phe Arg Val Gln 
                245                 250                 255     


Ala Leu Asp Pro Asp Glu Gly Ser Asn Gly Glu Val Gln Tyr Ser Leu 
            260                 265                 270         


Ser Asn Ser Thr Gln Ala Glu Leu Arg His Arg Phe His Val His Pro 
        275                 280                 285             


Lys Ser Gly Glu Val Gln Val Ala Ala Ser Leu Gly Pro Pro Glu Thr 
    290                 295                 300                 


Leu Leu Glu Ala Tyr Ile Glu Ala Arg Asp Glu Gly Val Phe Gly Leu 
305                 310                 315                 320 


Ala Ser Thr Ala Lys Leu Leu Val Glu Val Thr Asp Val Asn Asp His 
                325                 330                 335     


Ala Pro Glu Leu Asp Phe Leu Thr Leu Ser Asn Pro Val Pro Glu Asp 
            340                 345                 350         


Ala Ala Pro Gly Thr Val Ile Ala Leu Phe Ser Val Lys Asp Glu Asp 
        355                 360                 365             


Leu Asp Ser Asn Gly Arg Val Ile Cys Gly Met Ser Ser Ala Gly Pro 
    370                 375                 380                 


Phe Gln Leu Thr Ala Ser Phe Asp Asn Tyr Tyr Ser Leu Leu Ile Asp 
385                 390                 395                 400 


Gly Pro Leu Asp Arg Glu Gln Ile Ser Glu Tyr Gln Val Leu Ile Thr 
                405                 410                 415     


Ala Ser Asp Ser Gly Ser Pro Pro Leu Ser Thr Arg Arg Thr Ile Thr 
            420                 425                 430         


Val Ser Val Ala Asp Val Asn Asp Asn Thr Pro Asn Phe Pro Gln Pro 
        435                 440                 445             


Gln Gln Glu Leu Phe Val Ala Glu Asn Asn Gly Pro Gly Ala Ser Leu 
    450                 455                 460                 


Gly Arg Val Phe Ala Gln Asp Pro Asp Leu Gly Lys Asn Gly Leu Val 
465                 470                 475                 480 


Ser Tyr Glu Leu Leu Asp Val Ile Ser Glu Gly Pro Ser Ala Ser Ser 
                485                 490                 495     


Leu Leu Ala Val Glu Ser Ser Ser Gly Ala Ile Thr Ala Lys Thr Ser 
            500                 505                 510         


Phe Asp Phe Glu Gln Leu Arg Gly Phe His Phe Gln Val Glu Gly Arg 
        515                 520                 525             


Asp Gly Gly Ile Pro Pro Arg Ser Ala Thr Val Thr Ile Asn Leu Phe 
    530                 535                 540                 


Val Val Asp Arg Asn Asp Asn Tyr Pro Val Ile Leu Phe Pro Leu Pro 
545                 550                 555                 560 


Arg Asn Gly Ser Val Pro Val Glu Ile Val Pro Arg Ser Ala Arg Thr 
                565                 570                 575     


Gly His Leu Val Thr Lys Val Val Ala Glu Asp Ala Asp Ser Gly Ser 
            580                 585                 590         


Asn Ala Trp Leu Ser Tyr His Ile Ser Arg Ala Ser Asp Ser Ser Leu 
        595                 600                 605             


Phe Arg Ile Ser Ala Asn Ile Gly Glu Leu Arg Thr Ala Arg Leu Val 
    610                 615                 620                 


Leu Pro Thr Asp Ala Val Lys Gln Arg Val Val Val Val Val Arg Asp 
625                 630                 635                 640 


His Gly Asp Pro Pro Leu Ser Ser Ser Val Thr Leu Gly Val Leu Leu 
                645                 650                 655     


Ser Asn Ser Val Pro Gln Leu Leu Pro Asp Phe Glu Asp Val Trp Glu 
            660                 665                 670         


Pro Gly Gly Gln Leu Ser Ala Gln Asn Leu Tyr Leu Val Ile Ala Leu 
        675                 680                 685             


Ala Cys Ile Ser Phe Leu Phe Leu Gly Cys Leu Leu Phe Phe Val Cys 
    690                 695                 700                 


Thr Lys Leu His Gln Ser Pro Gly Cys Cys Ala Gln Ser Cys Cys Arg 
705                 710                 715                 720 


Ser Thr Glu Asp Leu Arg Tyr Gly Ser Lys Met Val Ser Asn Pro Cys 
                725                 730                 735     


Met Thr Ser Ala Thr Ile Asp Val Thr Thr Val Glu Arg Leu Ser Gln 
            740                 745                 750         


Thr Tyr Leu Tyr Arg Ala Ser Leu Gly Leu Gly Ser Asp Asn Asn Ser 
        755                 760                 765             


Leu Leu Leu Arg Gly Glu Tyr Asn Ala Ala Asp Leu Arg Asn Leu Ala 
    770                 775                 780                 


Thr Gly Val Gly Leu Asn Leu Pro Ile Ser Cys Ile Gln Ile Arg Asn 
785                 790                 795                 800 


Arg Lys Gly Asp His Ala Asn Val Asn Ala Met Pro Arg Gln Pro Asn 
                805                 810                 815     


Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser 
            820                 825                 830         


Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro 
        835                 840                 845             


Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala 
    850                 855                 860                 


Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp 
865                 870                 875                 880 


Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu 
                885                 890                 895     


Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile 
            900                 905                 910         


Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr 
        915                 920                 925             


Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly 
    930                 935                 940                 


Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn 
945                 950                 955                 960 


Ser Asp Gln 
            


<210>  4509
<211>  948
<212>  PRT
<213>  Homo sapiens

<400>  4509

Met Ala Ser Ser Ile Arg Arg Gly Arg Gly Ala Trp Thr Arg Leu Leu 
1               5                   10                  15      


Ser Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu Arg 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Glu Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Val Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Glu Val Glu Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Ile Phe Pro Met Thr Val Lys Thr Ile Arg Phe Pro Glu 
    130                 135                 140                 


Ser Arg Leu Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Val Asn Ala Leu Leu Ser Tyr Lys Leu Ser Ser Ser Glu 
                165                 170                 175     


Phe Phe Phe Leu Asp Ile Gln Ala Asn Asp Glu Leu Ser Glu Ser Leu 
            180                 185                 190         


Ser Leu Val Leu Gly Lys Ser Leu Asp Arg Glu Glu Thr Ala Glu Val 
        195                 200                 205             


Asn Leu Leu Leu Val Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Ile Leu Ile Lys Val Leu Asp Val Asn Asp Asn Glu Pro 
225                 230                 235                 240 


Thr Phe Ala Gln Ser Val Tyr Lys Val Lys Leu Leu Glu Asn Thr Ala 
                245                 250                 255     


Asn Gly Thr Leu Val Val Lys Leu Asn Ala Ser Asp Ala Asp Glu Gly 
            260                 265                 270         


Pro Asn Ser Glu Ile Val Tyr Ser Leu Gly Ser Asp Val Ser Ser Thr 
        275                 280                 285             


Ile Gln Thr Lys Phe Thr Ile Asp Pro Ile Ser Gly Glu Ile Arg Thr 
    290                 295                 300                 


Lys Gly Lys Leu Asp Tyr Glu Glu Ala Lys Ser Tyr Glu Ile Gln Val 
305                 310                 315                 320 


Thr Ala Thr Asp Lys Gly Thr Pro Ser Met Ser Gly His Cys Lys Ile 
                325                 330                 335     


Ser Leu Lys Leu Val Asp Ile Asn Asp Asn Thr Pro Glu Val Ser Ile 
            340                 345                 350         


Thr Ser Leu Ser Leu Pro Ile Ser Glu Asn Ala Ser Leu Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Thr Val Ser Asp Arg Asp Ser Gly Thr Asn Gly His 
    370                 375                 380                 


Val Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Thr Ser Val Ser Ile Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Val 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Ala Pro Arg Ala Gly Thr Ala Ala Gly Ala 
                565                 570                 575     


Val Ser Glu Leu Val Pro Trp Ser Val Gly Ala Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Leu Gly Thr Gly Ser Ala Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Ala 
625                 630                 635                 640 


Asp Ser Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Ala Trp Val Gly Ala Ala Gly 
        675                 680                 685             


Ser Glu Ala Thr Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Val Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Val Pro Pro Thr Glu Gly Ala Arg Ala Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Gln Arg Val Cys Ser Gly Glu Asp Pro Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Ser Gln Gly Pro Asp Ser Ala Glu 
    770                 775                 780                 


Glu Lys Gln Leu Ser Glu Ser Glu Tyr Val Gly Lys Pro Arg Gln Pro 
785                 790                 795                 800 


Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser 
                805                 810                 815     


Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly 
            820                 825                 830         


Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu 
        835                 840                 845             


Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser 
    850                 855                 860                 


Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly 
865                 870                 875                 880 


Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser 
                885                 890                 895     


Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile 
            900                 905                 910         


Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp 
    930                 935                 940                 


Asn Ser Asp Gln 
945             


<210>  4510
<211>  936
<212>  PRT
<213>  Homo sapiens

<400>  4510

Met Val Tyr Ser Arg Arg Gly Ser Leu Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Trp Leu Leu Leu Ala Tyr Trp Lys Ala Gly Ser Gly Gln Leu His Tyr 
            20                  25                  30          


Ser Ile Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile Ala 
        35                  40                  45              


Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe Arg 
    50                  55                  60                  


Val Ala Ser Lys Gly Arg Gly Asp Leu Leu Glu Val Asn Leu Gln Asn 
65                  70                  75                  80  


Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys Arg 
                85                  90                  95      


Arg Arg Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg Pro 
            100                 105                 110         


Leu Gln Val Phe His Val Glu Val Ala Val Lys Asp Ile Asn Asp Asn 
        115                 120                 125             


Pro Pro Arg Phe Ser Arg Gln Glu Gln Arg Leu Phe Ile Leu Glu Ser 
    130                 135                 140                 


Arg Met Pro Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Leu Asp 
145                 150                 155                 160 


Ile Gly Ala Asn Ala Gln Leu Arg Tyr Arg Leu Asn Pro Asn Glu Tyr 
                165                 170                 175     


Phe Asp Leu Asp Val Lys Thr Asn Glu Glu Glu Thr Asn Phe Leu Glu 
            180                 185                 190         


Leu Val Leu Arg Lys Ser Leu Asp Arg Glu Glu Thr Gln Glu His Arg 
        195                 200                 205             


Leu Leu Val Ile Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly Thr 
    210                 215                 220                 


Val Gln Leu Leu Ile Asn Val Leu Asp Ala Asn Asp Asn Ala Pro Glu 
225                 230                 235                 240 


Phe Asp Lys Ser Ile Tyr Asn Val Arg Leu Leu Glu Asn Ala Pro Ser 
                245                 250                 255     


Gly Thr Leu Val Ile Lys Leu Asn Ala Ser Asp Ala Asp Glu Gly Ile 
            260                 265                 270         


Asn Lys Glu Ile Val Tyr Phe Phe Ser Asn Leu Val Leu Asp Asp Val 
        275                 280                 285             


Lys Ser Lys Phe Ile Ile Asn Ser Asn Thr Gly Glu Ile Lys Val Asn 
    290                 295                 300                 


Gly Glu Leu Asp Tyr Glu Asp Tyr Asn Ser Tyr Glu Ile Asn Ile Asp 
305                 310                 315                 320 


Ala Met Asp Lys Ser Thr Phe Pro Leu Ser Gly His Cys Lys Val Val 
                325                 330                 335     


Val Lys Leu Leu Asp Val Asn Asp Asn Thr Pro Glu Met Ala Ile Thr 
            340                 345                 350         


Thr Leu Phe Leu Pro Val Lys Glu Asp Ala Pro Leu Ser Thr Val Ile 
        355                 360                 365             


Ala Leu Ile Ser Val Ser Asp Arg Asp Ser Gly Ala Asn Gly Gln Val 
    370                 375                 380                 


Thr Cys Ser Leu Met Pro His Val Pro Phe Lys Leu Val Ser Thr Phe 
385                 390                 395                 400 


Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu Ser 
                405                 410                 415     


Val Ser Val Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser Pro 
            420                 425                 430         


Ser Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Ala Phe Ala Gln Pro Gln Tyr Thr Val Phe Val Lys 
    450                 455                 460                 


Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg Asp 
465                 470                 475                 480 


Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu Arg 
                485                 490                 495     


Arg Val Gly Glu Arg Pro Leu Ser Ser Tyr Val Ser Val His Ala Glu 
            500                 505                 510         


Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Val Glu 
        515                 520                 525             


Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro Leu 
    530                 535                 540                 


Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Leu Leu Val Pro Arg Val Gly Gly Thr Gly Gly Ala Val 
                565                 570                 575     


Ser Glu Leu Val Pro Arg Ser Val Gly Ala Gly His Val Val Ala Lys 
            580                 585                 590         


Val Arg Ala Val Asp Pro Asp Ser Gly Tyr Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Glu Leu Gln Pro Ala Pro Gly Ser Ala Arg Ile Pro Phe Arg Val Gly 
    610                 615                 620                 


Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ser Leu Asp Glu Thr Glu 
625                 630                 635                 640 


Ala Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu Pro 
                645                 650                 655     


Pro Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser Gly 
            660                 665                 670         


Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Ala Gly Ala Val Gly Pro 
        675                 680                 685             


Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile Cys 
    690                 695                 700                 


Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala Leu 
705                 710                 715                 720 


Arg Cys Ser Ala Gln Pro Thr Glu Ala Val Cys Thr Arg Gly Lys Pro 
                725                 730                 735     


Thr Leu Leu Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln Gln 
            740                 745                 750         


Arg Arg Gln Arg Val Cys Ser Gly Glu Ala Pro Pro Lys Thr Asp Leu 
        755                 760                 765             


Met Ala Phe Ser Pro Ser Leu Pro Gln Gly Pro Thr Ser Thr Asp Asn 
    770                 775                 780                 


Pro Arg Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala 
785                 790                 795                 800 


Gly Met His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala 
                805                 810                 815     


Gly Pro Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr 
            820                 825                 830         


Pro Glu Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val 
        835                 840                 845             


Asn Ser Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln 
    850                 855                 860                 


Ser Gly Pro Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro 
865                 870                 875                 880 


Ala Ile Ile Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys 
                885                 890                 895     


Ser Asp Phe Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys 
            900                 905                 910         


Lys Lys Lys Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn 
        915                 920                 925             


Ser Thr Thr Asp Asn Ser Asp Gln 
    930                 935     


<210>  4511
<211>  950
<212>  PRT
<213>  Homo sapiens

<400>  4511

Met Val Phe Thr Pro Glu Asp Arg Leu Gly Lys Gln Cys Leu Leu Leu 
1               5                   10                  15      


Pro Leu Leu Leu Leu Ala Ala Trp Lys Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Met Ala Ser Lys Asp Arg Glu Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Arg Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Leu Phe Pro Val Glu Glu Gln Arg Val Leu Ile Tyr Glu 
    130                 135                 140                 


Ser Arg Leu Pro Asp Ser Val Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Val Gly Ser Asn Ser Ile Leu Thr Tyr Lys Leu Ser Ser Ser Glu 
                165                 170                 175     


Tyr Phe Gly Leu Asp Val Lys Ile Asn Ser Asp Asp Asn Lys Gln Ile 
            180                 185                 190         


Gly Leu Leu Leu Lys Lys Ser Leu Asp Arg Glu Glu Ala Pro Ala His 
        195                 200                 205             


Asn Leu Phe Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Val Thr Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Thr Phe Glu Gln Ser Glu Tyr Glu Val Arg Ile Phe Glu Asn Ala Asp 
                245                 250                 255     


Asn Gly Thr Thr Val Ile Arg Leu Asn Ala Ser Asp Arg Asp Glu Gly 
            260                 265                 270         


Ala Asn Gly Ala Ile Ser Tyr Ser Phe Asn Ser Leu Val Ala Ala Met 
        275                 280                 285             


Val Ile Asp His Phe Ser Ile Asp Arg Asn Thr Gly Glu Ile Val Ile 
    290                 295                 300                 


Arg Gly Asn Leu Asp Phe Glu Gln Glu Asn Leu Tyr Lys Ile Leu Ile 
305                 310                 315                 320 


Asp Ala Thr Asp Lys Gly His Pro Pro Met Ala Gly His Cys Thr Val 
                325                 330                 335     


Leu Val Arg Ile Leu Asp Lys Asn Asp Asn Val Pro Glu Ile Ala Leu 
            340                 345                 350         


Thr Ser Leu Ser Leu Pro Val Arg Glu Asp Ala Gln Phe Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Asn Asp Leu Asp Ser Gly Ala Asn Gly Gln 
    370                 375                 380                 


Val Asn Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Leu Ser Val Glu Val Ala Asp Met 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Ile Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Ala Pro Arg Val Gly Gly Thr Gly Gly Ala 
                565                 570                 575     


Val Ser Glu Leu Val Pro Arg Ser Leu Gly Ala Gly Gln Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Pro Ala Ser Ser Ala Arg Phe Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Val Leu Asp Glu Ala 
625                 630                 635                 640 


Asp Ser Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Val Gly Ala Ala Gly 
        675                 680                 685             


Pro Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Pro Pro Thr Glu Gly Ala Cys Thr Ala Asp Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Gln Arg Val Cys Ser Gly Glu Gly Pro Pro Lys Met Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Ser Pro Cys Pro Ile Met Met Gly 
    770                 775                 780                 


Lys Ala Glu Asn Gln Asp Leu Asn Glu Asp His Asp Ala Lys Pro Arg 
785                 790                 795                 800 


Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met 
                805                 810                 815     


His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro 
            820                 825                 830         


Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu 
        835                 840                 845             


Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser 
    850                 855                 860                 


Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly 
865                 870                 875                 880 


Pro Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile 
                885                 890                 895     


Ile Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp 
            900                 905                 910         


Phe Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Lys Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr 
    930                 935                 940                 


Thr Asp Asn Ser Asp Gln 
945                 950 


<210>  4512
<211>  950
<212>  PRT
<213>  Homo sapiens

<400>  4512

Met Asp Tyr His Trp Arg Gly Glu Leu Gly Ser Trp Arg Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ala Ala Trp Lys Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Arg His Arg Asp Leu Leu Glu Val Ser Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Val Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Arg Val Lys Asp Gln Lys Leu Phe Val Ser Glu 
    130                 135                 140                 


Ser Arg Met Pro Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Val Gly Ala Asn Ser Val Leu Thr Tyr Arg Leu Ser Ser His Asp 
                165                 170                 175     


Tyr Phe Met Leu Asp Val Asn Ser Lys Asn Asp Glu Asn Lys Leu Val 
            180                 185                 190         


Glu Leu Val Leu Arg Lys Ser Leu Asp Arg Glu Asp Ala Pro Ala His 
        195                 200                 205             


His Leu Phe Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Val Thr Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Thr Phe Glu Gln Ser Glu Tyr Glu Val Arg Ile Phe Glu Asn Ala Asp 
                245                 250                 255     


Asn Gly Thr Thr Val Ile Lys Leu Asn Ala Ser Asp Pro Asp Glu Gly 
            260                 265                 270         


Ala Asn Gly Ala Ile Ser Tyr Ser Phe Asn Ser Leu Val Glu Thr Met 
        275                 280                 285             


Val Ile Asp His Phe Ser Ile Asp Arg Asn Thr Gly Glu Ile Val Ile 
    290                 295                 300                 


Arg Gly Asn Leu Asp Phe Glu Gln Glu Asn Leu Tyr Lys Ile Leu Ile 
305                 310                 315                 320 


Asp Ala Thr Asp Lys Gly His Pro Pro Met Ala Gly His Cys Thr Val 
                325                 330                 335     


Leu Val Arg Ile Leu Asp Lys Asn Asp Asn Val Pro Glu Ile Ala Leu 
            340                 345                 350         


Thr Ser Leu Ser Leu Pro Val Arg Glu Asp Ala Gln Phe Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Asn Asp Leu Asp Ser Gly Ala Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Ser Leu Met Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Arg Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Leu Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ser Leu Ser Ser Tyr Ile Ser Val His Thr 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Glu Pro Arg Val Gly Gly Thr Gly Gly Ala 
                565                 570                 575     


Ala Ser Lys Leu Val Pro Arg Ser Val Gly Ala Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Ala Ala Ser Ser Pro Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Val Leu Asp Glu Ala 
625                 630                 635                 640 


Asp Ser Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Gln Ser Ala Gly Val Leu Gly 
        675                 680                 685             


Pro Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Leu Pro Thr Glu Gly Gly Cys Arg Ala Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Gln Pro Gln Arg Val Cys Ser Gly Glu Gly Pro Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Cys Leu Pro Pro Asp Leu Gly Ser Val Asp 
    770                 775                 780                 


Val Gly Glu Glu Gln Asp Leu Asn Val Asp His Gly Leu Lys Pro Arg 
785                 790                 795                 800 


Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met 
                805                 810                 815     


His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro 
            820                 825                 830         


Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu 
        835                 840                 845             


Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser 
    850                 855                 860                 


Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly 
865                 870                 875                 880 


Pro Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile 
                885                 890                 895     


Ile Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp 
            900                 905                 910         


Phe Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Lys Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr 
    930                 935                 940                 


Thr Asp Asn Ser Asp Gln 
945                 950 


<210>  4513
<211>  931
<212>  PRT
<213>  Homo sapiens

<400>  4513

Met Lys Ile Gln Lys Lys Leu Thr Gly Cys Ser Arg Leu Met Leu Leu 
1               5                   10                  15      


Cys Leu Ser Leu Glu Leu Leu Leu Glu Ala Gly Ala Gly Asn Ile His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Thr Asp Lys Gly Ser Phe Val Gly Asn Ile 
        35                  40                  45              


Ala Lys Asp Leu Gly Leu Gln Pro Gln Glu Leu Ala Asp Gly Gly Val 
    50                  55                  60                  


Arg Ile Val Ser Arg Gly Arg Met Pro Leu Phe Ala Leu Asn Pro Arg 
65                  70                  75                  80  


Ser Gly Ser Leu Ile Thr Ala Arg Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Ala Gln Ser Met Pro Cys Leu Val Ser Phe Asn Ile Leu Val Glu Asp 
            100                 105                 110         


Lys Met Lys Leu Phe Pro Val Glu Val Glu Ile Ile Asp Ile Asn Asp 
        115                 120                 125             


Asn Thr Pro Gln Phe Gln Leu Glu Glu Leu Glu Phe Lys Met Asn Glu 
    130                 135                 140                 


Ile Thr Thr Pro Gly Thr Arg Val Ser Leu Pro Phe Gly Gln Asp Leu 
145                 150                 155                 160 


Asp Val Gly Met Asn Ser Leu Gln Ser Tyr Gln Leu Ser Ser Asn Pro 
                165                 170                 175     


His Phe Ser Leu Asp Val Gln Gln Gly Ala Asp Gly Pro Gln His Pro 
            180                 185                 190         


Glu Met Val Leu Gln Ser Pro Leu Asp Arg Glu Glu Glu Ala Val His 
        195                 200                 205             


His Leu Ile Leu Thr Ala Ser Asp Gly Gly Glu Pro Val Arg Ser Gly 
    210                 215                 220                 


Thr Leu Arg Ile Tyr Ile Gln Val Val Asp Ala Asn Asp Asn Pro Pro 
225                 230                 235                 240 


Ala Phe Thr Gln Ala Gln Tyr His Ile Asn Val Pro Glu Asn Val Pro 
                245                 250                 255     


Leu Gly Thr Gln Leu Leu Met Val Asn Ala Thr Asp Pro Asp Glu Gly 
            260                 265                 270         


Ala Asn Gly Glu Val Thr Tyr Ser Phe His Asn Val Asp His Arg Val 
        275                 280                 285             


Ala Gln Ile Phe Arg Leu Asp Ser Tyr Thr Gly Glu Ile Ser Asn Lys 
    290                 295                 300                 


Glu Pro Leu Asp Phe Glu Glu Tyr Lys Met Tyr Ser Met Glu Val Gln 
305                 310                 315                 320 


Ala Gln Asp Gly Ala Gly Leu Met Ala Lys Val Lys Val Leu Ile Lys 
                325                 330                 335     


Val Leu Asp Val Asn Asp Asn Ala Pro Glu Val Thr Ile Thr Ser Val 
            340                 345                 350         


Thr Thr Ala Val Pro Glu Asn Phe Pro Pro Gly Thr Ile Ile Ala Leu 
        355                 360                 365             


Ile Ser Val His Asp Gln Asp Ser Gly Asp Asn Gly Tyr Thr Thr Cys 
    370                 375                 380                 


Phe Ile Pro Gly Asn Leu Pro Phe Lys Leu Glu Lys Leu Val Asp Asn 
385                 390                 395                 400 


Tyr Tyr Arg Leu Val Thr Glu Arg Thr Leu Asp Arg Glu Leu Ile Ser 
                405                 410                 415     


Gly Tyr Asn Ile Thr Ile Thr Ala Ile Asp Gln Gly Thr Pro Ala Leu 
            420                 425                 430         


Ser Thr Glu Thr His Ile Ser Leu Leu Val Thr Asp Ile Asn Asp Asn 
        435                 440                 445             


Ser Pro Val Phe His Gln Asp Ser Tyr Ser Ala Tyr Ile Pro Glu Asn 
    450                 455                 460                 


Asn Pro Arg Gly Ala Ser Ile Phe Ser Val Arg Ala His Asp Leu Asp 
465                 470                 475                 480 


Ser Asn Glu Asn Ala Gln Ile Thr Tyr Ser Leu Ile Glu Asp Thr Ile 
                485                 490                 495     


Gln Gly Ala Pro Leu Ser Ala Tyr Leu Ser Ile Asn Ser Asp Thr Gly 
            500                 505                 510         


Val Leu Tyr Ala Leu Arg Ser Phe Asp Tyr Glu Gln Phe Arg Asp Met 
        515                 520                 525             


Gln Leu Lys Val Met Ala Arg Asp Ser Gly Asp Pro Pro Leu Ser Ser 
    530                 535                 540                 


Asn Val Ser Leu Ser Leu Phe Leu Leu Asp Gln Asn Asp Asn Ala Pro 
545                 550                 555                 560 


Glu Ile Leu Tyr Pro Ala Leu Pro Thr Asp Gly Ser Thr Gly Val Glu 
                565                 570                 575     


Leu Ala Pro Leu Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val 
            580                 585                 590         


Ala Val Asp Arg Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Arg Leu 
        595                 600                 605             


Leu Lys Ala Ser Glu Pro Gly Leu Phe Ser Val Gly Leu His Thr Gly 
    610                 615                 620                 


Glu Val Arg Thr Ala Arg Ala Leu Leu Asp Arg Asp Ala Leu Lys Gln 
625                 630                 635                 640 


Ser Leu Val Val Ala Val Gln Asp His Gly Gln Pro Pro Leu Ser Ala 
                645                 650                 655     


Thr Val Thr Leu Thr Val Ala Val Ala Asp Arg Ile Ser Asp Ile Leu 
            660                 665                 670         


Ala Asp Leu Gly Ser Leu Glu Pro Ser Ala Lys Pro Asn Asp Ser Asp 
        675                 680                 685             


Leu Thr Leu Tyr Leu Val Val Ala Ala Ala Ala Val Ser Cys Val Phe 
    690                 695                 700                 


Leu Ala Phe Val Ile Val Leu Leu Ala His Arg Leu Arg Arg Trp His 
705                 710                 715                 720 


Lys Ser Arg Leu Leu Gln Ala Ser Gly Gly Gly Leu Ala Ser Met Pro 
                725                 730                 735     


Gly Ser His Phe Val Gly Val Asp Gly Val Arg Ala Phe Leu Gln Thr 
            740                 745                 750         


Tyr Ser His Glu Val Ser Leu Thr Ala Asp Ser Arg Lys Ser His Leu 
        755                 760                 765             


Ile Phe Pro Gln Pro Asn Tyr Ala Asp Thr Leu Ile Ser Gln Glu Ser 
    770                 775                 780                 


Cys Glu Lys Lys Gly Phe Leu Ser Ala Pro Gln Ser Leu Leu Glu Asp 
785                 790                 795                 800 


Lys Lys Glu Pro Phe Ser Gln Gln Ala Pro Pro Asn Thr Asp Trp Arg 
                805                 810                 815     


Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly Asp 
            820                 825                 830         


Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu Gln 
        835                 840                 845             


Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser Thr 
    850                 855                 860                 


Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly Pro 
865                 870                 875                 880 


Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr Ile 
                885                 890                 895     


Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp Gly 
            900                 905                 910         


Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys Lys 
        915                 920                 925             


Glu Lys Lys 
    930     


<210>  4514
<211>  936
<212>  PRT
<213>  Homo sapiens

<400>  4514

Met Ala Ala Gln Arg Asn Arg Ser Lys Glu Ser Lys Asp Cys Ser Gly 
1               5                   10                  15      


Leu Val Leu Leu Cys Leu Phe Phe Gly Ile Pro Trp Glu Ala Gly Ala 
            20                  25                  30          


Arg Gln Ile Ser Tyr Ser Ile Pro Glu Glu Leu Glu Lys Gly Ser Phe 
        35                  40                  45              


Val Gly Asn Ile Ser Lys Asp Leu Gly Leu Ala Pro Arg Glu Leu Ala 
    50                  55                  60                  


Glu Arg Gly Val Arg Ile Val Ser Arg Gly Arg Thr Gln Leu Phe Ser 
65                  70                  75                  80  


Leu Asn Pro Arg Ser Gly Ser Leu Ile Thr Ala Gly Arg Ile Asp Arg 
                85                  90                  95      


Glu Glu Leu Cys Ala Gln Ser Ala Arg Cys Val Val Ser Phe Asn Ile 
            100                 105                 110         


Leu Val Glu Asp Arg Val Lys Leu Phe Gly Ile Glu Ile Glu Val Thr 
        115                 120                 125             


Asp Ile Asn Asp Asn Ala Pro Lys Phe Gln Ala Glu Asn Leu Asp Val 
    130                 135                 140                 


Lys Ile Asn Glu Asn Val Ala Ala Gly Met Arg Phe Pro Leu Pro Glu 
145                 150                 155                 160 


Ala Ile Asp Pro Asp Val Gly Val Asn Ser Leu Gln Ser Tyr Gln Leu 
                165                 170                 175     


Ser Pro Asn Lys His Phe Ser Leu Arg Val Gln Ser Arg Ala Asn Gly 
            180                 185                 190         


Val Lys Tyr Pro Glu Leu Val Leu Glu His Ser Leu Asp Arg Glu Glu 
        195                 200                 205             


Glu Ala Ile His His Leu Val Leu Thr Ala Ser Asp Gly Gly Asp Pro 
    210                 215                 220                 


Leu Arg Ser Gly Thr Val Leu Val Ser Val Thr Val Phe Asp Ala Asn 
225                 230                 235                 240 


Asp Asn Ala Pro Val Phe Thr Leu Pro Glu Tyr Arg Val Ser Val Pro 
                245                 250                 255     


Glu Asn Leu Pro Val Gly Thr Gln Leu Leu Thr Val Thr Ala Thr Asp 
            260                 265                 270         


Arg Asp Glu Gly Ala Asn Gly Glu Val Thr Tyr Ser Phe Arg Lys Leu 
        275                 280                 285             


Pro Asp Thr Gln Leu Leu Lys Phe Gln Leu Asn Lys Tyr Thr Gly Glu 
    290                 295                 300                 


Ile Lys Ile Ser Glu Asn Leu Asp Tyr Glu Glu Thr Gly Phe Tyr Glu 
305                 310                 315                 320 


Ile Glu Ile Gln Ala Glu Asp Gly Gly Ala Tyr Leu Ala Thr Ala Lys 
                325                 330                 335     


Val Leu Ile Thr Val Glu Asp Val Asn Asp Asn Ser Pro Glu Leu Thr 
            340                 345                 350         


Ile Thr Ser Leu Phe Ser Pro Val Thr Glu Asp Ser Pro Leu Gly Thr 
        355                 360                 365             


Val Val Ala Leu Leu Asn Val His Asp Leu Asp Ser Glu Gln Asn Gly 
    370                 375                 380                 


Gln Val Thr Cys Ser Ile Leu Ala Tyr Leu Pro Phe Lys Leu Glu Lys 
385                 390                 395                 400 


Ser Ile Asp Ser Tyr Tyr Arg Leu Val Ile His Arg Ala Leu Asp Arg 
                405                 410                 415     


Glu Gln Val Ser Ser Tyr Asn Ile Thr Val Thr Ala Thr Asp Gly Gly 
            420                 425                 430         


Ser Pro Pro Leu Ser Thr Glu Ala His Phe Met Leu Gln Val Ala Asp 
        435                 440                 445             


Ile Asn Asp Asn Pro Pro Thr Phe Ser Gln Val Ser Tyr Phe Thr Tyr 
    450                 455                 460                 


Ile Pro Glu Asn Asn Ala Arg Gly Ala Ser Ile Phe Ser Val Thr Ala 
465                 470                 475                 480 


Leu Asp Pro Asp Ser Lys Glu Asn Ala Gln Ile Ile Tyr Ser Leu Ala 
                485                 490                 495     


Glu Asp Thr Ile Gln Gly Val Pro Leu Ser Ser Tyr Ile Ser Ile Asn 
            500                 505                 510         


Ser Asp Thr Gly Val Leu Tyr Ala Leu Arg Ser Phe Asp Tyr Glu Gln 
        515                 520                 525             


Phe His Glu Leu Gln Met Gln Val Thr Ala Ser Asp Ser Gly Asp Pro 
    530                 535                 540                 


Pro Leu Ser Ser Asn Val Ser Leu Ser Leu Phe Val Leu Asp Gln Asn 
545                 550                 555                 560 


Asp Asn Ala Pro Glu Ile Leu Tyr Pro Ala Leu Pro Thr Asp Gly Ser 
                565                 570                 575     


Thr Gly Val Glu Leu Ala Pro Arg Ser Ala Glu Pro Gly Tyr Leu Val 
            580                 585                 590         


Thr Lys Val Val Ala Val Asp Arg Asp Ser Gly Gln Asn Ala Trp Leu 
        595                 600                 605             


Ser Tyr Arg Leu Leu Lys Ala Ser Glu Pro Gly Leu Phe Ala Val Gly 
    610                 615                 620                 


Glu His Thr Gly Glu Val Arg Thr Ala Arg Ala Leu Leu Asp Arg Asp 
625                 630                 635                 640 


Ala Leu Lys Gln Ser Leu Val Val Ala Val Gln Asp His Gly Gln Pro 
                645                 650                 655     


Pro Leu Ser Ala Thr Val Thr Leu Thr Val Ala Val Ala Asp Ser Ile 
            660                 665                 670         


Pro Gln Val Leu Ala Asp Leu Gly Ser Phe Glu Ser Pro Ala Asn Ser 
        675                 680                 685             


Glu Thr Ser Asp Leu Thr Leu Tyr Leu Val Val Ala Val Ala Ala Val 
    690                 695                 700                 


Ser Cys Val Phe Leu Ala Phe Val Ile Val Leu Leu Ala His Arg Leu 
705                 710                 715                 720 


Arg Arg Trp His Lys Ser Arg Leu Leu Gln Ala Ser Gly Gly Gly Leu 
                725                 730                 735     


Thr Gly Val Ser Gly Ser His Phe Val Gly Val Asp Gly Val Arg Ala 
            740                 745                 750         


Phe Leu Gln Thr Tyr Ser His Glu Val Ser Leu Thr Ala Asp Ser Arg 
        755                 760                 765             


Lys Ser His Leu Ile Phe Pro Gln Pro Asn Tyr Ala Asp Thr Leu Ile 
    770                 775                 780                 


Ser Gln Glu Ser Cys Glu Lys Asn Asp Pro Leu Ser Leu Leu Asp Asp 
785                 790                 795                 800 


Ser Lys Phe Pro Ile Glu Asp Thr Pro Leu Val Pro Gln Ala Pro Pro 
                805                 810                 815     


Asn Thr Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly 
            820                 825                 830         


Ser Gln Asn Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp 
        835                 840                 845             


Thr Glu Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala 
    850                 855                 860                 


Asp Gly Ser Ser Thr Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser 
865                 870                 875                 880 


Ala Arg Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg 
                885                 890                 895     


Gln Asn Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala 
            900                 905                 910         


Gly Lys Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys 
        915                 920                 925             


Lys Ser Gly Lys Lys Glu Lys Lys 
    930                 935     


<210>  4515
<211>  935
<212>  PRT
<213>  Homo sapiens

<400>  4515

Met Ala Asn Arg Leu Gln Arg Gly Asp Arg Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Cys Ile Phe Leu Gly Thr Leu Arg Gly Phe Arg Ala Arg Gln Ile 
            20                  25                  30          


Arg Tyr Ser Val Pro Glu Glu Thr Glu Lys Gly Ser Phe Val Gly Asn 
        35                  40                  45              


Ile Ser Lys Asp Leu Gly Leu Glu Pro Arg Glu Leu Ala Lys Arg Gly 
    50                  55                  60                  


Val Arg Ile Val Ser Arg Gly Lys Thr Gln Leu Phe Ala Val Asn Pro 
65                  70                  75                  80  


Arg Ser Gly Ser Leu Ile Thr Ala Gly Arg Ile Asp Arg Glu Glu Leu 
                85                  90                  95      


Cys Glu Thr Val Ser Ser Cys Phe Leu Asn Met Glu Leu Leu Val Glu 
            100                 105                 110         


Asp Thr Leu Lys Ile Tyr Gly Val Glu Val Glu Ile Ile Asp Ile Asn 
        115                 120                 125             


Asp Asn Ala Pro Ser Phe Gln Glu Asp Glu Val Glu Ile Lys Val Ser 
    130                 135                 140                 


Glu His Ala Ile Pro Gly Ala Arg Phe Ala Leu Pro Asn Ala Arg Asp 
145                 150                 155                 160 


Pro Asp Val Gly Val Asn Ser Leu Gln Ser Tyr Gln Leu Ser Pro Asn 
                165                 170                 175     


Asn Tyr Phe Ser Leu Gln Leu Arg Gly Arg Thr Asp Gly Ala Lys Asn 
            180                 185                 190         


Pro Glu Leu Val Leu Glu Gly Ser Leu Asp Arg Glu Lys Glu Ala Ala 
        195                 200                 205             


His Leu Leu Leu Leu Thr Ala Leu Asp Gly Gly Asp Pro Ile Arg Lys 
    210                 215                 220                 


Gly Ala Val Pro Ile Arg Val Val Val Leu Asp Val Asn Asp His Ile 
225                 230                 235                 240 


Pro Met Phe Thr Gln Ser Val Tyr Arg Val Ser Val Pro Glu Asn Ile 
                245                 250                 255     


Ser Ser Gly Thr Arg Val Leu Met Val Asn Ala Thr Asp Pro Asp Glu 
            260                 265                 270         


Gly Ile Asn Gly Glu Val Met Tyr Ser Phe Arg Asn Met Glu Ser Lys 
        275                 280                 285             


Ala Ser Glu Ile Phe Gln Leu Asp Ser Gln Thr Gly Glu Val Gln Val 
    290                 295                 300                 


Arg Gly Ser Leu Asp Phe Glu Lys Tyr Arg Phe Tyr Glu Met Glu Ile 
305                 310                 315                 320 


Gln Gly Gln Asp Gly Gly Gly Leu Phe Thr Thr Thr Thr Met Leu Ile 
                325                 330                 335     


Thr Val Val Asp Val Asn Asp Asn Ala Pro Glu Ile Thr Ile Thr Ser 
            340                 345                 350         


Ser Ile Asn Ser Ile Leu Glu Asn Ser Pro Pro Gly Thr Val Ile Ala 
        355                 360                 365             


Leu Leu Asn Val Gln Asp Gln Asp Ser Gly Glu Asn Gly Gln Val Ser 
    370                 375                 380                 


Cys Phe Ile Pro Asn His Leu Pro Phe Lys Leu Glu Lys Thr Tyr Gly 
385                 390                 395                 400 


Asn Tyr Tyr Lys Leu Ile Thr Ser Arg Val Leu Asp Arg Glu Leu Val 
                405                 410                 415     


Gln Ser Tyr Asn Ile Thr Leu Thr Ala Thr Asp Gln Gly Ser Pro Pro 
            420                 425                 430         


Leu Ser Ala Glu Thr His Val Trp Leu Asn Val Ala Asp Asp Asn Asp 
        435                 440                 445             


Asn Pro Pro Val Phe Pro His Ser Ser Tyr Ser Ala Tyr Ile Pro Glu 
    450                 455                 460                 


Asn Asn Pro Arg Gly Ala Ser Ile Phe Ser Val Thr Ala Leu Asp Pro 
465                 470                 475                 480 


Asp Ser Lys Gln Asn Ala Leu Val Thr Tyr Ser Leu Thr Asp Asp Thr 
                485                 490                 495     


Val Gln Gly Val Pro Leu Ser Ser Tyr Val Ser Ile Asn Ser Asn Thr 
            500                 505                 510         


Gly Val Leu Tyr Ala Leu Gln Ser Phe Asp Tyr Glu Gln Phe Arg Asp 
        515                 520                 525             


Leu Glu Leu Arg Val Ile Ala Arg Asp Ser Gly Asp Pro Pro Leu Ser 
    530                 535                 540                 


Ser Asn Val Ser Leu Ser Leu Phe Val Leu Asp Gln Asn Asp Asn Ala 
545                 550                 555                 560 


Pro Glu Ile Leu Tyr Pro Ala Leu Pro Thr Asp Gly Ser Thr Gly Val 
                565                 570                 575     


Glu Leu Ala Pro Arg Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val 
            580                 585                 590         


Val Ala Val Asp Lys Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Arg 
        595                 600                 605             


Leu Leu Lys Ala Ser Glu Pro Gly Leu Phe Ala Val Gly Glu His Thr 
    610                 615                 620                 


Gly Glu Val Arg Thr Ala Arg Ala Leu Leu Asp Arg Asp Ala Leu Lys 
625                 630                 635                 640 


Gln Ser Leu Val Val Ala Val Gln Asp His Gly Gln Pro Pro Leu Ser 
                645                 650                 655     


Ala Thr Val Thr Leu Thr Val Ala Val Ala Asp Ser Ile Pro Glu Val 
            660                 665                 670         


Leu Ala Asp Leu Gly Ser Leu Glu Ser Leu Ala Asn Ser Glu Thr Ser 
        675                 680                 685             


Asp Leu Ser Leu Tyr Leu Val Val Ala Val Ala Ala Val Ser Cys Ile 
    690                 695                 700                 


Phe Leu Val Phe Val Ile Val Leu Leu Ala Leu Arg Leu Trp Arg Trp 
705                 710                 715                 720 


His Lys Ser Arg Leu Leu Gln Ala Ser Glu Gly Gly Leu Ala Gly Met 
                725                 730                 735     


Pro Thr Ser His Phe Val Gly Val Asp Gly Val Gln Ala Phe Leu Gln 
            740                 745                 750         


Thr Tyr Ser His Glu Val Ser Leu Ile Ala Asp Ser Gln Lys Ser His 
        755                 760                 765             


Leu Ile Phe Pro Gln Pro Asn Tyr Gly Asp Thr Leu Ile Ser Gln Glu 
    770                 775                 780                 


Ser Cys Glu Lys Ser Glu Pro Leu Leu Ile Ala Glu Asp Ser Ala Ile 
785                 790                 795                 800 


Ile Leu Gly Lys Cys Asp Pro Thr Ser Asn Gln Gln Ala Pro Pro Asn 
                805                 810                 815     


Thr Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser 
            820                 825                 830         


Gln Asn Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr 
        835                 840                 845             


Glu Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp 
    850                 855                 860                 


Gly Ser Ser Thr Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala 
865                 870                 875                 880 


Arg Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln 
                885                 890                 895     


Asn Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly 
            900                 905                 910         


Lys Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys 
        915                 920                 925             


Ser Gly Lys Lys Glu Lys Lys 
    930                 935 


<210>  4516
<211>  932
<212>  PRT
<213>  Homo sapiens

<400>  4516

Met Ala Ala Pro Thr Lys Cys Gln Leu Arg Gly Arg Leu Val Leu Leu 
1               5                   10                  15      


Cys Ser Leu Leu Gly Met Leu Trp Glu Ala Arg Ala Ser Gln Ile Arg 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Thr Glu Lys Gly Tyr Ile Val Gly Asn Ile 
        35                  40                  45              


Ser Lys Asp Leu Ala Leu Glu Pro Arg Glu Leu Ala Glu Arg Arg Val 
    50                  55                  60                  


Arg Ile Val Ser Arg Gly Arg Thr Gln Leu Phe Ser Leu Asn Pro Arg 
65                  70                  75                  80  


Ser Gly Thr Leu Val Thr Ala Gly Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Ala Gln Ser Pro Arg Cys Leu Val Asn Phe Lys Val Leu Val Glu Asp 
            100                 105                 110         


Arg Val Lys Leu Tyr Gly Ile Glu Ile Glu Val Thr Asp Ile Asn Asp 
        115                 120                 125             


Ser Ala Pro Lys Phe Gln Ala Glu Ser Leu Glu Val Lys Ile Asn Glu 
    130                 135                 140                 


Ile Ala Val Pro Gly Ala Arg Tyr Pro Leu Pro Glu Ala Ile Asp Pro 
145                 150                 155                 160 


Asp Val Gly Val Asn Ser Leu Gln Ser Tyr Gln Leu Ser Pro Asn His 
                165                 170                 175     


His Phe Ser Leu Asn Val Gln Thr Gly Asp Asn Gly Ala Ile Asn Pro 
            180                 185                 190         


Glu Leu Val Leu Glu Arg Ala Leu Asp Arg Glu Glu Ala Thr Ala His 
        195                 200                 205             


His Leu Val Leu Thr Ala Ser Asp Gly Gly Glu Pro Arg Arg Ser Ser 
    210                 215                 220                 


Thr Val Arg Ile His Val Thr Val Leu Asp Thr Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Val Phe Ala Gln Arg Ile Tyr Arg Val Lys Val Leu Glu Asn Val Pro 
                245                 250                 255     


Pro Gly Thr Trp Leu Leu Thr Ala Thr Ala Ser Asp Leu Asp Glu Gly 
            260                 265                 270         


Ile Asn Gly Lys Val Ala Tyr Lys Phe Trp Lys Ile Asn Glu Lys Gln 
        275                 280                 285             


Ser Leu Leu Phe Gln Leu Asn Glu Asn Thr Gly Glu Ile Ser Thr Ala 
    290                 295                 300                 


Lys Ser Leu Asp Tyr Glu Glu Cys Ser Phe Tyr Glu Met Glu Ile Gln 
305                 310                 315                 320 


Ala Glu Asp Gly Gly Gly Leu Lys Gly Trp Thr Lys Val Leu Ile Ser 
                325                 330                 335     


Val Glu Asp Val Asn Asp Asn Arg Pro Glu Val Thr Ile Thr Ser Leu 
            340                 345                 350         


Phe Ser Pro Val Arg Glu Asp Ala Pro Gln Gly Thr Val Ile Leu Leu 
        355                 360                 365             


Phe Asn Ala His Asp Arg Asp Ser Gly Lys Asn Gly Gln Val Val Cys 
    370                 375                 380                 


Ser Ile Gln Glu Asn Leu Ser Phe Thr Leu Glu Asn Ser Glu Glu Asp 
385                 390                 395                 400 


Tyr Tyr Arg Leu Leu Thr Ala Gln Ile Leu Asp Arg Glu Lys Ala Ser 
                405                 410                 415     


Glu Tyr Asn Ile Thr Val Thr Ala Thr Asp Arg Gly Thr Pro Pro Leu 
            420                 425                 430         


Ser Thr Glu Ile His Ile Thr Leu Gln Val Thr Asp Ile Asn Asp Asn 
        435                 440                 445             


Pro Pro Ala Phe Ser Gln Ala Ser Tyr Ser Val Tyr Leu Pro Glu Asn 
    450                 455                 460                 


Asn Ala Arg Gly Thr Ser Ile Phe Ser Val Ile Ala Tyr Asp Pro Asp 
465                 470                 475                 480 


Ser Asn Glu Asn Ser Arg Val Ile Tyr Ser Leu Ala Glu Asp Thr Ile 
                485                 490                 495     


Gln Gly Ser Pro Leu Ser Thr Tyr Val Ser Ile Asn Ser Asp Thr Gly 
            500                 505                 510         


Val Leu Tyr Ala Leu Cys Ser Phe Asp Tyr Glu Gln Phe Arg Asp Leu 
        515                 520                 525             


Gln Met Gln Val Thr Ala Ser Asp Ser Gly Ser Pro Pro Leu Ser Ser 
    530                 535                 540                 


Asn Val Ser Leu Arg Leu Phe Val Leu Asp Gln Asn Asp Asn Ala Pro 
545                 550                 555                 560 


Glu Ile Leu Tyr Pro Ala Leu Pro Thr Asp Gly Ser Thr Gly Val Glu 
                565                 570                 575     


Leu Ala Pro Arg Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val 
            580                 585                 590         


Ala Val Asp Arg Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Arg Leu 
        595                 600                 605             


Phe Lys Ala Ser Glu Pro Gly Leu Phe Ser Val Gly Leu His Thr Gly 
    610                 615                 620                 


Glu Val Arg Thr Ala Arg Ala Leu Leu Asp Arg Asp Ala Leu Lys Gln 
625                 630                 635                 640 


Ser Leu Val Val Ala Val Gln Asp His Gly Gln Pro Pro Leu Ser Ala 
                645                 650                 655     


Thr Val Thr Leu Thr Val Ala Ile Ala Asp Ser Ile Pro Asp Ile Leu 
            660                 665                 670         


Ala Asp Leu Gly Ser Leu Gln Ile Pro Ala Asp Leu Glu Ala Ser Asp 
        675                 680                 685             


Leu Thr Leu Tyr Leu Val Val Ala Val Ala Val Val Ser Cys Val Phe 
    690                 695                 700                 


Leu Thr Phe Val Ile Thr Leu Leu Ala Leu Arg Leu Arg His Trp His 
705                 710                 715                 720 


Ser Ser His Leu Leu Arg Ala Thr Ser Asp Gly Leu Ala Gly Val Pro 
                725                 730                 735     


Thr Ser His Phe Val Gly Val Asp Gly Val Arg Ala Phe Leu Gln Thr 
            740                 745                 750         


Tyr Ser Gln Glu Phe Ser Leu Thr Ala Asp Ser Arg Lys Ser His Leu 
        755                 760                 765             


Ile Phe Pro Gln Pro Asn Tyr Ala Asp Thr Leu Ile Ser Gln Gln Ser 
    770                 775                 780                 


Cys Glu Lys Asn Glu Pro Leu Cys Val Ser Val Asp Ser Lys Phe Pro 
785                 790                 795                 800 


Ile Glu Asp Thr Pro Leu Val Pro Gln Ala Pro Pro Asn Thr Asp Trp 
                805                 810                 815     


Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly 
            820                 825                 830         


Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu 
        835                 840                 845             


Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser 
    850                 855                 860                 


Thr Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly 
865                 870                 875                 880 


Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr 
                885                 890                 895     


Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp 
            900                 905                 910         


Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys 
        915                 920                 925             


Lys Glu Lys Lys 
    930         


<210>  4517
<211>  923
<212>  PRT
<213>  Homo sapiens

<400>  4517

Met Gly Ser Gly Ala Gly Glu Leu Gly Arg Ala Glu Arg Leu Pro Val 
1               5                   10                  15      


Leu Phe Leu Phe Leu Leu Ser Leu Phe Cys Pro Ala Leu Cys Glu Gln 
            20                  25                  30          


Ile Arg Tyr Arg Ile Pro Glu Glu Met Pro Lys Gly Ser Val Val Gly 
        35                  40                  45              


Asn Leu Ala Thr Asp Leu Gly Phe Ser Val Gln Glu Leu Pro Thr Arg 
    50                  55                  60                  


Lys Leu Arg Val Ser Ser Glu Lys Pro Tyr Phe Thr Val Ser Ala Glu 
65                  70                  75                  80  


Ser Gly Glu Leu Leu Val Ser Ser Arg Leu Asp Arg Glu Glu Ile Cys 
                85                  90                  95      


Gly Lys Lys Pro Ala Cys Ala Leu Glu Phe Glu Ala Val Ala Glu Asn 
            100                 105                 110         


Pro Leu Asn Phe Tyr His Val Asn Val Glu Ile Glu Asp Ile Asn Asp 
        115                 120                 125             


His Thr Pro Lys Phe Thr Gln Asn Ser Phe Glu Leu Gln Ile Ser Glu 
    130                 135                 140                 


Ser Ala Gln Pro Gly Thr Arg Phe Ile Leu Glu Val Ala Glu Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Leu Asn Ser Leu Gln Lys Tyr Lys Leu Ser Leu Asn Pro 
                165                 170                 175     


Ser Phe Ser Leu Ile Ile Lys Glu Lys Gln Asp Gly Ser Lys Tyr Pro 
            180                 185                 190         


Glu Leu Ala Leu Glu Lys Thr Leu Asp Arg Glu Gln Gln Ser Tyr His 
        195                 200                 205             


Arg Leu Val Leu Thr Ala Leu Asp Gly Gly His Pro Pro Leu Ser Gly 
    210                 215                 220                 


Thr Thr Glu Leu Arg Ile Gln Val Thr Asp Ala Asn Asp Asn Pro Pro 
225                 230                 235                 240 


Val Phe Asn Arg Asp Val Tyr Arg Val Ser Leu Arg Glu Asn Val Pro 
                245                 250                 255     


Pro Gly Thr Thr Val Leu Gln Val Ser Ala Thr Asp Gln Asp Glu Gly 
            260                 265                 270         


Ile Asn Ser Glu Ile Thr Tyr Ser Phe Tyr Arg Thr Gly Gln Ile Phe 
        275                 280                 285             


Ser Leu Asn Ser Lys Ser Gly Glu Ile Thr Thr Gln Lys Lys Leu Asp 
    290                 295                 300                 


Phe Glu Glu Thr Lys Glu Tyr Ser Met Val Val Glu Gly Arg Asp Gly 
305                 310                 315                 320 


Gly Gly Leu Val Ala Gln Cys Thr Val Glu Ile Asn Ile Gln Asp Glu 
                325                 330                 335     


Asn Asp Asn Ser Pro Glu Val Thr Phe His Ser Leu Leu Glu Met Ile 
            340                 345                 350         


Leu Glu Asn Ala Val Pro Gly Thr Leu Ile Ala Leu Ile Lys Ile His 
        355                 360                 365             


Asp Gln Asp Ser Gly Glu Asn Gly Glu Val Asn Cys Gln Leu Gln Gly 
    370                 375                 380                 


Glu Val Pro Phe Lys Ile Ile Ser Ser Ser Lys Asn Ser Tyr Lys Leu 
385                 390                 395                 400 


Val Thr Asp Gly Thr Leu Asp Arg Glu Gln Thr Pro Glu Tyr Asn Val 
                405                 410                 415     


Thr Ile Thr Ala Thr Asp Arg Gly Lys Pro Pro Leu Ser Ser Ser Ile 
            420                 425                 430         


Ser Val Ile Leu His Ile Arg Asp Val Asn Asp Asn Ala Pro Val Phe 
        435                 440                 445             


His Gln Ala Ser Tyr Leu Val Ser Val Pro Glu Asn Asn Pro Pro Gly 
    450                 455                 460                 


Ala Ser Ile Ala Gln Val Cys Ala Ser Asp Leu Asp Leu Gly Leu Asn 
465                 470                 475                 480 


Gly Gln Val Ser Tyr Ser Ile Met Ala Ser Asp Leu Glu Pro Leu Ala 
                485                 490                 495     


Leu Ala Ser Tyr Val Ser Met Ser Ala Gln Ser Gly Val Val Phe Ala 
            500                 505                 510         


Gln Arg Ala Phe Asp Tyr Glu Gln Leu Arg Thr Phe Glu Leu Thr Leu 
        515                 520                 525             


Gln Ala Arg Asp Gln Gly Ser Pro Ala Leu Ser Ala Asn Val Ser Leu 
    530                 535                 540                 


Arg Val Leu Val Gly Asp Arg Asn Asp Asn Ala Pro Arg Val Leu Tyr 
545                 550                 555                 560 


Pro Ala Leu Gly Pro Asp Gly Ser Ala Leu Phe Asp Met Val Pro Arg 
                565                 570                 575     


Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val Asp Ala 
            580                 585                 590         


Asp Ser Gly His Asn Ala Trp Leu Ser Tyr His Val Leu Gln Ala Ser 
        595                 600                 605             


Glu Pro Gly Leu Phe Ser Leu Gly Leu Arg Thr Gly Glu Val Arg Thr 
    610                 615                 620                 


Ala Arg Ala Leu Gly Asp Arg Asp Ala Ala Arg Gln Arg Leu Leu Val 
625                 630                 635                 640 


Ala Val Arg Asp Gly Gly Gln Pro Pro Leu Ser Ala Thr Ala Thr Leu 
                645                 650                 655     


His Leu Val Phe Ala Asp Ser Leu Gln Glu Val Leu Pro Asp Ile Thr 
            660                 665                 670         


Asp Arg Pro Val Pro Ser Asp Pro Gln Ala Glu Leu Gln Phe Tyr Leu 
        675                 680                 685             


Val Val Ala Leu Ala Leu Ile Ser Val Leu Phe Leu Leu Ala Val Ile 
    690                 695                 700                 


Leu Ala Val Ala Leu Arg Leu Arg Arg Ser Ser Ser Pro Ala Ala Trp 
705                 710                 715                 720 


Ser Cys Phe Gln Pro Gly Leu Cys Val Lys Ser Gly Pro Val Val Pro 
                725                 730                 735     


Pro Asn Tyr Ser Gln Gly Thr Leu Pro Tyr Ser Tyr Asn Leu Cys Val 
            740                 745                 750         


Ala His Thr Gly Lys Thr Glu Phe Asn Phe Leu Lys Cys Ser Glu Gln 
        755                 760                 765             


Leu Ser Ser Gly Gln Asp Ile Leu Cys Gly Asp Ser Ser Gly Ala Leu 
    770                 775                 780                 


Phe Pro Leu Cys Asn Ser Ser Glu Ser Thr Ser His Pro Glu Leu Gln 
785                 790                 795                 800 


Ala Pro Pro Asn Thr Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly 
                805                 810                 815     


Thr Ser Gly Ser Gln Asn Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn 
            820                 825                 830         


Gln Phe Asp Thr Glu Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser 
        835                 840                 845             


Glu Ala Ala Asp Gly Ser Ser Thr Leu Gly Gly Gly Ala Gly Thr Met 
    850                 855                 860                 


Gly Leu Ser Ala Arg Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro 
865                 870                 875                 880 


Asp Tyr Arg Gln Asn Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr 
                885                 890                 895     


Asn Ala Ala Gly Lys Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly 
            900                 905                 910         


Asn Lys Lys Lys Ser Gly Lys Lys Glu Lys Lys 
        915                 920             


<210>  4518
<211>  930
<212>  PRT
<213>  Homo sapiens

<400>  4518

Met Gly Gly Ser Cys Ala Gln Arg Arg Arg Ala Gly Pro Arg Gln Val 
1               5                   10                  15      


Leu Phe Pro Leu Leu Leu Pro Leu Phe Tyr Pro Thr Leu Ser Glu Pro 
            20                  25                  30          


Ile Arg Tyr Ser Ile Pro Glu Glu Leu Ala Lys Gly Ser Val Val Gly 
        35                  40                  45              


Asn Leu Ala Lys Asp Leu Gly Leu Ser Val Leu Asp Val Ser Ala Arg 
    50                  55                  60                  


Lys Leu Arg Val Ser Ala Glu Lys Leu His Phe Ser Val Asp Ala Glu 
65                  70                  75                  80  


Ser Gly Asp Leu Leu Val Lys Asn Arg Ile Asp Arg Glu Gln Ile Cys 
                85                  90                  95      


Lys Glu Arg Arg Arg Cys Glu Leu Gln Leu Glu Ala Val Val Glu Asn 
            100                 105                 110         


Pro Leu Asn Ile Phe His Val Ile Val Val Ile Glu Asp Val Asn Asp 
        115                 120                 125             


His Ala Pro Gln Phe Asp Lys Lys Glu Ile His Leu Glu Ile Phe Glu 
    130                 135                 140                 


Ser Ala Ser Ala Gly Thr Arg Leu Ser Leu Asp Pro Ala Thr Asp Pro 
145                 150                 155                 160 


Asp Ile Asn Ile Asn Ser Ile Lys Asp Tyr Lys Ile Asn Ser Asn Pro 
                165                 170                 175     


Tyr Phe Ser Leu Met Val Arg Val Asn Ser Asp Gly Gly Lys Tyr Pro 
            180                 185                 190         


Glu Leu Ser Leu Glu Lys Leu Leu Asp Arg Glu Glu Gln Arg Ser His 
        195                 200                 205             


Ser Leu Ile Leu Thr Ala Leu Asp Gly Gly Asp Pro Pro Arg Ser Ala 
    210                 215                 220                 


Thr Ala His Ile Glu Ile Ser Val Lys Asp Thr Asn Asp Asn Pro Pro 
225                 230                 235                 240 


Val Phe Ser Arg Asp Glu Tyr Arg Ile Ser Leu Ser Glu Asn Leu Pro 
                245                 250                 255     


Pro Gly Ser Pro Val Leu Gln Val Thr Ala Thr Asp Gln Asp Glu Gly 
            260                 265                 270         


Val Asn Ala Glu Ile Asn Tyr Tyr Phe Arg Ser Thr Ala Gln Ser Thr 
        275                 280                 285             


Lys His Met Phe Ser Leu Asp Glu Lys Thr Gly Met Ile Lys Asn Asn 
    290                 295                 300                 


Gln Ser Phe Asp Phe Glu Asp Val Glu Arg Tyr Thr Met Glu Val Glu 
305                 310                 315                 320 


Ala Lys Asp Gly Gly Gly Leu Ser Thr Gln Cys Lys Val Ile Ile Glu 
                325                 330                 335     


Ile Leu Asp Glu Asn Asp Asn Ser Pro Glu Ile Ile Ile Thr Ser Leu 
            340                 345                 350         


Ser Asp Gln Ile Leu Glu Asn Ser Pro Pro Gly Met Val Val Ala Leu 
        355                 360                 365             


Phe Lys Thr Arg Asp Leu Asp Phe Gly Gly Asn Gly Glu Val Arg Cys 
    370                 375                 380                 


Asn Ile Glu Thr Asp Ile Pro Phe Lys Ile Tyr Ser Ser Ser Asn Asn 
385                 390                 395                 400 


Tyr Tyr Lys Leu Val Thr Asp Gly Ala Leu Asp Arg Glu Gln Thr Pro 
                405                 410                 415     


Glu Tyr Asn Val Thr Ile Val Ala Thr Asp Arg Gly Lys Pro Pro Leu 
            420                 425                 430         


Ser Ser Ser Arg Ser Ile Thr Leu Tyr Val Ala Asp Ile Asn Asp Asn 
        435                 440                 445             


Ala Pro Val Phe Asp Gln Thr Ser Tyr Val Val His Val Ala Glu Asn 
    450                 455                 460                 


Asn Pro Pro Gly Ala Ser Ile Ala Gln Val Ser Ala Ser Asp Pro Asp 
465                 470                 475                 480 


Leu Gly Leu Asn Gly His Ile Ser Tyr Ser Ile Val Ala Ser Asp Leu 
                485                 490                 495     


Glu Pro Leu Ala Val Ser Ser Tyr Val Ser Val Ser Ala Gln Ser Gly 
            500                 505                 510         


Val Val Phe Ala Gln Arg Ala Phe Asp His Glu Gln Leu Arg Ala Phe 
        515                 520                 525             


Ala Leu Thr Leu Gln Ala Arg Asp His Gly Ser Pro Thr Leu Ser Ala 
    530                 535                 540                 


Asn Val Ser Leu Arg Val Leu Val Gly Asp Arg Asn Asp Asn Ala Pro 
545                 550                 555                 560 


Arg Val Leu Tyr Pro Ala Leu Gly Pro Asp Gly Ser Ala Phe Phe Asp 
                565                 570                 575     


Met Val Pro Arg Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val 
            580                 585                 590         


Ala Val Asp Ala Asp Ser Gly His Asn Ala Trp Leu Ser Tyr His Val 
        595                 600                 605             


Leu Gln Ala Ser Glu Pro Gly Leu Phe Ser Leu Gly Leu Arg Thr Gly 
    610                 615                 620                 


Glu Val Arg Thr Ala Arg Ala Leu Gly Asp Arg Asp Ala Ala Arg Gln 
625                 630                 635                 640 


Arg Leu Leu Val Ala Val Arg Asp Gly Gly Gln Pro Pro Leu Ser Ala 
                645                 650                 655     


Thr Ala Thr Leu His Leu Val Phe Ala Asp Asn Leu Gln Glu Ile Leu 
            660                 665                 670         


Pro Asp Leu Ser Asp Arg Pro Val Leu Ser Asp Pro Gln Ala Glu Leu 
        675                 680                 685             


Gln Phe Tyr Leu Val Val Ala Leu Ala Leu Ile Ser Val Leu Phe Leu 
    690                 695                 700                 


Leu Ala Val Ile Leu Ala Ile Ala Leu Arg Leu Arg Arg Ser Leu Ser 
705                 710                 715                 720 


Pro Ala Thr Trp Asp Cys Phe His Pro Gly Leu Cys Val Lys Ser Gly 
                725                 730                 735     


Pro Val Val Pro Pro Asn Tyr Ser Glu Gly Thr Leu Pro Tyr Ser Tyr 
            740                 745                 750         


Asn Leu Cys Ile Ala His Thr Gly Thr Lys Glu Phe Asn Phe Leu Lys 
        755                 760                 765             


Cys Ser Val Pro Leu His Ser Asn Glu Asp Met Val Cys Ser Val Ser 
    770                 775                 780                 


Pro Gly Ala Leu Ile Pro Pro His Gly Gly Glu Asp Leu Thr Ser His 
785                 790                 795                 800 


Pro Glu Thr Leu Thr Ser Gln Ala Pro Pro Asn Thr Asp Trp Arg Phe 
                805                 810                 815     


Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly Asp Asp 
            820                 825                 830         


Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu Gln Ala 
        835                 840                 845             


Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser Thr Leu 
    850                 855                 860                 


Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly Pro Gln 
865                 870                 875                 880 


Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr Ile Pro 
                885                 890                 895     


Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp Gly Lys 
            900                 905                 910         


Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys Lys Glu 
        915                 920                 925             


Lys Lys 
    930 


<210>  4519
<211>  934
<212>  PRT
<213>  Homo sapiens

<400>  4519

Met Val Pro Glu Ala Trp Arg Ser Gly Leu Val Ser Thr Gly Arg Val 
1               5                   10                  15      


Val Gly Val Leu Leu Leu Leu Gly Ala Leu Asn Lys Ala Ser Thr Val 
            20                  25                  30          


Ile His Tyr Glu Ile Pro Glu Glu Arg Glu Lys Gly Phe Ala Val Gly 
        35                  40                  45              


Asn Val Val Ala Asn Leu Gly Leu Asp Leu Gly Ser Leu Ser Ala Arg 
    50                  55                  60                  


Arg Phe Arg Val Val Ser Gly Ala Ser Arg Arg Phe Phe Glu Val Asn 
65                  70                  75                  80  


Arg Glu Thr Gly Glu Met Phe Val Asn Asp Arg Leu Asp Arg Glu Glu 
                85                  90                  95      


Leu Cys Gly Thr Leu Pro Ser Cys Thr Val Thr Leu Glu Leu Val Val 
            100                 105                 110         


Glu Asn Pro Leu Glu Leu Phe Ser Val Glu Val Val Ile Gln Asp Ile 
        115                 120                 125             


Asn Asp Asn Asn Pro Ala Phe Pro Thr Gln Glu Met Lys Leu Glu Ile 
    130                 135                 140                 


Ser Glu Ala Val Ala Pro Gly Thr Arg Phe Pro Leu Glu Ser Ala His 
145                 150                 155                 160 


Asp Pro Asp Val Gly Ser Asn Ser Leu Gln Thr Tyr Glu Leu Ser Arg 
                165                 170                 175     


Asn Glu Tyr Phe Ala Leu Arg Val Gln Thr Arg Glu Asp Ser Thr Lys 
            180                 185                 190         


Tyr Ala Glu Leu Val Leu Glu Arg Ala Leu Asp Arg Glu Arg Glu Pro 
        195                 200                 205             


Ser Leu Gln Leu Val Leu Thr Ala Leu Asp Gly Gly Thr Pro Ala Leu 
    210                 215                 220                 


Ser Ala Ser Leu Pro Ile His Ile Lys Val Leu Asp Ala Asn Asp Asn 
225                 230                 235                 240 


Ala Pro Val Phe Asn Gln Ser Leu Tyr Arg Ala Arg Val Leu Glu Asp 
                245                 250                 255     


Ala Pro Ser Gly Thr Arg Val Val Gln Val Leu Ala Thr Asp Leu Asp 
            260                 265                 270         


Glu Gly Pro Asn Gly Glu Ile Ile Tyr Ser Phe Gly Ser His Asn Arg 
        275                 280                 285             


Ala Gly Val Arg Gln Leu Phe Ala Leu Asp Leu Val Thr Gly Met Leu 
    290                 295                 300                 


Thr Ile Lys Gly Arg Leu Asp Phe Glu Asp Thr Lys Leu His Glu Ile 
305                 310                 315                 320 


Tyr Ile Gln Ala Lys Asp Lys Gly Ala Asn Pro Glu Gly Ala His Cys 
                325                 330                 335     


Lys Val Leu Val Glu Val Val Asp Val Asn Asp Asn Ala Pro Glu Ile 
            340                 345                 350         


Thr Val Thr Ser Val Tyr Ser Pro Val Pro Glu Asp Ala Pro Leu Gly 
        355                 360                 365             


Thr Val Ile Ala Leu Leu Ser Val Thr Asp Leu Asp Ala Gly Glu Asn 
    370                 375                 380                 


Gly Leu Val Thr Cys Glu Val Pro Pro Gly Leu Pro Phe Ser Leu Thr 
385                 390                 395                 400 


Ser Ser Leu Lys Asn Tyr Phe Thr Leu Lys Thr Ser Ala Asp Leu Asp 
                405                 410                 415     


Arg Glu Thr Val Pro Glu Tyr Asn Leu Ser Ile Thr Ala Arg Asp Ala 
            420                 425                 430         


Gly Thr Pro Ser Leu Ser Ala Leu Thr Ile Val Arg Val Gln Val Ser 
        435                 440                 445             


Asp Ile Asn Asp Asn Pro Pro Gln Ser Ser Gln Ser Ser Tyr Asp Val 
    450                 455                 460                 


Tyr Ile Glu Glu Asn Asn Leu Pro Gly Ala Pro Ile Leu Asn Leu Ser 
465                 470                 475                 480 


Val Trp Asp Pro Asp Ala Pro Gln Asn Ala Arg Leu Ser Phe Phe Leu 
                485                 490                 495     


Leu Glu Gln Gly Ala Glu Thr Gly Leu Val Gly Arg Tyr Phe Thr Ile 
            500                 505                 510         


Asn Arg Asp Asn Gly Ile Val Ser Ser Leu Val Pro Leu Asp Tyr Glu 
        515                 520                 525             


Asp Arg Arg Glu Phe Glu Leu Thr Ala His Ile Ser Asp Gly Gly Thr 
    530                 535                 540                 


Pro Val Leu Ala Thr Asn Ile Ser Val Asn Ile Phe Val Thr Asp Arg 
545                 550                 555                 560 


Asn Asp Asn Ala Pro Gln Val Leu Tyr Pro Arg Pro Gly Gly Ser Ser 
                565                 570                 575     


Val Glu Met Leu Pro Arg Gly Thr Ser Ala Gly His Leu Val Ser Arg 
            580                 585                 590         


Val Val Gly Trp Asp Ala Asp Ala Gly His Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Ser Leu Leu Gly Ser Pro Asn Gln Ser Leu Phe Ala Ile Gly Leu His 
    610                 615                 620                 


Thr Gly Gln Ile Ser Thr Ala Arg Pro Val Gln Asp Thr Asp Ser Pro 
625                 630                 635                 640 


Arg Gln Thr Leu Thr Val Leu Ile Lys Asp Asn Gly Glu Pro Ser Leu 
                645                 650                 655     


Ser Thr Thr Ala Thr Leu Thr Val Ser Val Thr Glu Asp Ser Pro Glu 
            660                 665                 670         


Ala Arg Ala Glu Phe Pro Ser Gly Ser Ala Pro Arg Glu Gln Lys Lys 
        675                 680                 685             


Asn Leu Thr Phe Tyr Leu Leu Leu Ser Leu Ile Leu Val Ser Val Gly 
    690                 695                 700                 


Phe Val Val Thr Val Phe Gly Val Ile Ile Phe Lys Val Tyr Lys Trp 
705                 710                 715                 720 


Lys Gln Ser Arg Asp Leu Tyr Arg Ala Pro Val Ser Ser Leu Tyr Arg 
                725                 730                 735     


Thr Pro Gly Pro Ser Leu His Ala Asp Ala Val Arg Gly Gly Leu Met 
            740                 745                 750         


Ser Pro His Leu Tyr His Gln Val Tyr Leu Thr Thr Asp Ser Arg Arg 
        755                 760                 765             


Ser Asp Pro Leu Leu Lys Lys Pro Gly Ala Ala Ser Pro Leu Ala Ser 
    770                 775                 780                 


Arg Gln Asn Thr Leu Arg Ser Cys Asp Pro Val Phe Tyr Arg Gln Val 
785                 790                 795                 800 


Leu Gly Ala Glu Ser Ala Pro Pro Gly Gln Gln Ala Pro Pro Asn Thr 
                805                 810                 815     


Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln 
            820                 825                 830         


Asn Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu 
        835                 840                 845             


Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly 
    850                 855                 860                 


Ser Ser Thr Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg 
865                 870                 875                 880 


Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn 
                885                 890                 895     


Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys 
            900                 905                 910         


Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser 
        915                 920                 925             


Gly Lys Lys Glu Lys Lys 
    930                 


<210>  4520
<211>  938
<212>  PRT
<213>  Homo sapiens

<400>  4520

Met Leu Arg Lys Val Arg Ser Trp Thr Glu Ile Trp Arg Trp Ala Thr 
1               5                   10                  15      


Leu Leu Phe Leu Phe Tyr His Leu Gly Tyr Val Cys Gly Gln Ile Arg 
            20                  25                  30          


Tyr Pro Val Pro Glu Glu Ser Gln Glu Gly Thr Phe Val Gly Asn Val 
        35                  40                  45              


Ala Gln Asp Phe Leu Leu Asp Thr Asp Ser Leu Ser Ala Arg Arg Leu 
    50                  55                  60                  


Gln Val Ala Gly Glu Val Asn Gln Arg His Phe Arg Val Asp Leu Asp 
65                  70                  75                  80  


Ser Gly Ala Leu Leu Ile Lys Asn Pro Ile Asp Arg Glu Ala Leu Cys 
                85                  90                  95      


Gly Leu Ser Ala Ser Cys Ile Val Pro Leu Glu Phe Val Thr Glu Gly 
            100                 105                 110         


Pro Leu Glu Met Tyr Arg Ala Glu Val Glu Ile Val Asp Val Asn Asp 
        115                 120                 125             


His Ala Pro Arg Phe Pro Arg Gln Gln Leu Asp Leu Glu Ile Gly Glu 
    130                 135                 140                 


Ala Ala Pro Pro Gly Gln Arg Phe Pro Leu Glu Lys Ala Gln Asp Ala 
145                 150                 155                 160 


Asp Val Gly Ser Asn Ser Ile Ser Ser Tyr Arg Leu Ser Ser Asn Glu 
                165                 170                 175     


His Phe Ala Leu Asp Val Lys Lys Arg Ser Asp Gly Ser Leu Val Pro 
            180                 185                 190         


Glu Leu Leu Leu Glu Lys Pro Leu Asp Arg Glu Lys Gln Ser Asp Tyr 
        195                 200                 205             


Arg Leu Val Leu Thr Ala Val Asp Gly Gly Asn Pro Pro Arg Ser Gly 
    210                 215                 220                 


Thr Ala Glu Leu Arg Val Ser Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Ala Phe Gln Gln Ser Ser Tyr Arg Ile Ser Val Leu Glu Ser Ala Pro 
                245                 250                 255     


Ala Gly Met Val Leu Ile Gln Leu Asn Ala Ser Asp Pro Asp Leu Gly 
            260                 265                 270         


Pro Ser Gly Asn Val Thr Phe Tyr Phe Ser Gly His Thr Pro Asp Arg 
        275                 280                 285             


Val Arg Asn Leu Phe Ser Leu His Pro Thr Thr Gly Lys Leu Thr Leu 
    290                 295                 300                 


Leu Gly Pro Leu Asp Phe Glu Ser Glu Asn Tyr Tyr Glu Phe Asp Val 
305                 310                 315                 320 


Arg Ala Arg Asp Gly Gly Ser Pro Ala Met Glu Gln His Cys Ser Leu 
                325                 330                 335     


Arg Val Asp Leu Leu Asp Val Asn Asp Asn Ala Pro Tyr Ile Thr Val 
            340                 345                 350         


Thr Ser Glu Leu Gly Thr Leu Pro Glu Ser Ala Glu Pro Gly Thr Val 
        355                 360                 365             


Val Ala Leu Ile Ser Val Gln Asp Pro Asp Ser Gly Ser Asn Gly Asp 
    370                 375                 380                 


Val Ser Leu Arg Ile Pro Asp His Leu Pro Phe Ala Leu Lys Ser Ala 
385                 390                 395                 400 


Phe Arg Asn Gln Phe Ser Leu Val Thr Ala Gly Pro Leu Asp Arg Glu 
                405                 410                 415     


Ala Lys Ser Ser Tyr Asp Ile Met Val Thr Ala Ser Asp Ala Gly Asn 
            420                 425                 430         


Pro Pro Leu Ser Thr His Arg Thr Ile Phe Leu Asn Ile Ser Asp Val 
        435                 440                 445             


Asn Asp Asn Pro Pro Ser Phe Phe Gln Arg Ser His Glu Val Phe Val 
    450                 455                 460                 


Pro Glu Asn Asn Arg Pro Gly Asp Leu Leu Cys Ser Leu Ala Ala Ser 
465                 470                 475                 480 


Asp Pro Asp Ser Gly Leu Asn Ala Leu Ile Ser Tyr Ser Leu Leu Glu 
                485                 490                 495     


Pro Arg Asn Arg Asp Val Ser Ala Ser Ser Phe Ile Ser Leu Asn Pro 
            500                 505                 510         


Gln Thr Gly Ala Val His Ala Thr Arg Ser Phe Asp Tyr Glu Gln Thr 
        515                 520                 525             


Gln Thr Leu Gln Phe Glu Val Gln Ala Arg Asp Arg Gly Asn Pro Pro 
    530                 535                 540                 


Leu Ser Ser Thr Val Thr Val Arg Leu Phe Val Leu Asp Leu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Val Leu Arg Pro Arg Ala Arg Pro Gly Ser Leu Cys 
                565                 570                 575     


Pro Gln Ala Leu Pro Pro Ser Val Gly Ala Gly His Leu Ile Thr Lys 
            580                 585                 590         


Val Thr Ala Val Asp Leu Asp Ser Gly Tyr Asn Ala Trp Val Ser Tyr 
        595                 600                 605             


Gln Leu Leu Glu Ala Pro Asp Pro Ser Leu Phe Ala Val Ser Arg Tyr 
    610                 615                 620                 


Ala Gly Glu Val Arg Thr Ala Val Pro Ile Pro Ala Asp Leu Pro Pro 
625                 630                 635                 640 


Gln Lys Leu Val Ile Val Val Lys Asp Ser Gly Ser Pro Pro Leu Ser 
                645                 650                 655     


Thr Ser Val Thr Leu Leu Val Ser Leu Glu Glu Asp Thr His Pro Val 
            660                 665                 670         


Val Pro Asp Leu Arg Glu Ser Ser Ala Pro Arg Glu Gly Glu Ser Arg 
        675                 680                 685             


Leu Thr Leu Tyr Leu Ala Val Ser Leu Val Ala Ile Cys Phe Val Ser 
    690                 695                 700                 


Phe Gly Ser Phe Val Ala Leu Leu Ser Lys Cys Leu Arg Gly Ala Ala 
705                 710                 715                 720 


Cys Gly Val Thr Cys Phe Pro Ala Gly Thr Cys Ala Cys Leu Thr Arg 
                725                 730                 735     


Ser Arg Arg Arg Glu Gly Leu Pro Pro Ser Asn Gly Ile Leu Arg Ile 
            740                 745                 750         


Gln Leu Gly Ser Asp Asp Pro Ile Lys Phe Val Asp Val Gly Gly His 
        755                 760                 765             


Ser His Gly Cys Thr Pro Leu Ala Ser Ala Pro Thr Arg Ser Asp Ser 
    770                 775                 780                 


Phe Met Met Val Lys Ser Pro Ser Ala Pro Met Ala Gly Glu Pro Val 
785                 790                 795                 800 


Arg Pro Ser Cys Pro Pro Ser Asp Leu Leu Tyr Gly Leu Glu Gln Ala 
                805                 810                 815     


Pro Pro Asn Thr Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr 
            820                 825                 830         


Ser Gly Ser Gln Asn Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln 
        835                 840                 845             


Phe Asp Thr Glu Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser Glu 
    850                 855                 860                 


Ala Ala Asp Gly Ser Ser Thr Leu Gly Gly Gly Ala Gly Thr Met Gly 
865                 870                 875                 880 


Leu Ser Ala Arg Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro Asp 
                885                 890                 895     


Tyr Arg Gln Asn Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn 
            900                 905                 910         


Ala Ala Gly Lys Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn 
        915                 920                 925             


Lys Lys Lys Ser Gly Lys Lys Glu Lys Lys 
    930                 935             


<210>  4521
<211>  938
<212>  PRT
<213>  Homo sapiens

<400>  4521

Met Leu Arg Lys Val Arg Ser Trp Thr Glu Ile Trp Arg Trp Ala Thr 
1               5                   10                  15      


Leu Leu Phe Leu Phe Tyr His Leu Gly Tyr Val Cys Gly Gln Ile Arg 
            20                  25                  30          


Tyr Pro Val Pro Glu Glu Ser Gln Glu Gly Thr Phe Val Gly Asn Val 
        35                  40                  45              


Ala Gln Asp Phe Leu Leu Asp Thr Asp Ser Leu Ser Ala Arg Arg Leu 
    50                  55                  60                  


Gln Val Ala Gly Glu Val Asn Gln Arg His Phe Arg Val Asp Leu Asp 
65                  70                  75                  80  


Ser Gly Ala Leu Leu Ile Lys Asn Pro Ile Asp Arg Glu Ala Leu Cys 
                85                  90                  95      


Gly Leu Ser Ala Ser Cys Ile Val Pro Leu Glu Phe Val Thr Glu Gly 
            100                 105                 110         


Pro Leu Glu Met Tyr Arg Ala Glu Val Glu Ile Val Asp Val Asn Asp 
        115                 120                 125             


His Ala Pro Arg Phe Pro Arg Gln Gln Leu Asp Leu Glu Ile Gly Glu 
    130                 135                 140                 


Ala Ala Pro Pro Gly Gln Arg Phe Pro Leu Glu Lys Ala Gln Asp Ala 
145                 150                 155                 160 


Asp Val Gly Ser Asn Ser Ile Ser Ser Tyr Arg Leu Ser Ser Asn Glu 
                165                 170                 175     


His Phe Ala Leu Asp Val Lys Lys Arg Ser Asp Gly Ser Leu Val Pro 
            180                 185                 190         


Glu Leu Leu Leu Glu Lys Pro Leu Asp Arg Glu Lys Gln Ser Asp Tyr 
        195                 200                 205             


Arg Leu Val Leu Thr Ala Val Asp Gly Gly Asn Pro Pro Arg Ser Gly 
    210                 215                 220                 


Thr Ala Glu Leu Arg Val Ser Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Ala Phe Gln Gln Ser Ser Tyr Arg Ile Ser Val Leu Glu Ser Ala Pro 
                245                 250                 255     


Ala Gly Met Val Leu Ile Gln Leu Asn Ala Ser Asp Pro Asp Leu Gly 
            260                 265                 270         


Pro Ser Gly Asn Val Thr Phe Tyr Phe Ser Gly His Thr Pro Asp Arg 
        275                 280                 285             


Val Arg Asn Leu Phe Ser Leu His Pro Thr Thr Gly Lys Leu Thr Leu 
    290                 295                 300                 


Leu Gly Pro Leu Asp Phe Glu Ser Glu Asn Tyr Tyr Glu Phe Asp Val 
305                 310                 315                 320 


Arg Ala Arg Asp Gly Gly Ser Pro Ala Met Glu Gln His Cys Ser Leu 
                325                 330                 335     


Arg Val Asp Leu Leu Asp Val Asn Asp Asn Ala Pro Tyr Ile Thr Val 
            340                 345                 350         


Thr Ser Glu Leu Gly Thr Leu Pro Glu Ser Ala Glu Pro Gly Thr Val 
        355                 360                 365             


Val Ala Leu Ile Ser Val Gln Asp Pro Asp Ser Gly Ser Asn Gly Asp 
    370                 375                 380                 


Val Ser Leu Arg Ile Pro Asp His Leu Pro Phe Ala Leu Lys Ser Ala 
385                 390                 395                 400 


Phe Arg Asn Gln Phe Ser Leu Val Thr Ala Gly Pro Leu Asp Arg Glu 
                405                 410                 415     


Ala Lys Ser Ser Tyr Asp Ile Met Val Thr Ala Ser Asp Ala Gly Asn 
            420                 425                 430         


Pro Pro Leu Ser Thr His Arg Thr Ile Phe Leu Asn Ile Ser Asp Val 
        435                 440                 445             


Asn Asp Asn Pro Pro Ser Phe Phe Gln Arg Ser His Glu Val Phe Val 
    450                 455                 460                 


Pro Glu Asn Asn Arg Pro Gly Asp Leu Leu Cys Ser Leu Ala Ala Ser 
465                 470                 475                 480 


Asp Pro Asp Ser Gly Leu Asn Ala Leu Ile Ser Tyr Ser Leu Leu Glu 
                485                 490                 495     


Pro Arg Asn Arg Asp Val Ser Ala Ser Ser Phe Ile Ser Leu Asn Pro 
            500                 505                 510         


Gln Thr Gly Ala Val His Ala Thr Arg Ser Phe Asp Tyr Glu Gln Thr 
        515                 520                 525             


Gln Thr Leu Gln Phe Glu Val Gln Ala Arg Asp Arg Gly Asn Pro Pro 
    530                 535                 540                 


Leu Ser Ser Thr Val Thr Val Arg Leu Phe Val Leu Asp Leu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Val Leu Arg Pro Arg Ala Arg Pro Gly Ser Leu Cys 
                565                 570                 575     


Pro Gln Ala Leu Pro Pro Ser Val Gly Ala Gly His Leu Ile Thr Lys 
            580                 585                 590         


Val Thr Ala Val Asp Leu Asp Ser Gly Tyr Asn Ala Trp Val Ser Tyr 
        595                 600                 605             


Gln Leu Leu Glu Ala Pro Asp Pro Ser Leu Phe Ala Val Ser Arg Tyr 
    610                 615                 620                 


Ala Gly Glu Val Arg Thr Ala Val Pro Ile Pro Ala Asp Leu Pro Pro 
625                 630                 635                 640 


Gln Lys Leu Val Ile Val Val Lys Asp Ser Gly Ser Pro Pro Leu Ser 
                645                 650                 655     


Thr Ser Val Thr Leu Leu Val Ser Leu Glu Glu Asp Thr His Pro Val 
            660                 665                 670         


Val Pro Asp Leu Arg Glu Ser Ser Ala Pro Arg Glu Gly Glu Ser Arg 
        675                 680                 685             


Leu Thr Leu Tyr Leu Ala Val Ser Leu Val Ala Ile Cys Phe Val Ser 
    690                 695                 700                 


Phe Gly Ser Phe Val Ala Leu Leu Ser Lys Cys Leu Arg Gly Ala Ala 
705                 710                 715                 720 


Cys Gly Val Thr Cys Phe Pro Ala Gly Thr Cys Ala Cys Leu Thr Arg 
                725                 730                 735     


Ser Arg Arg Arg Glu Gly Leu Pro Pro Ser Asn Gly Ile Leu Arg Ile 
            740                 745                 750         


Gln Leu Gly Ser Asp Asp Pro Ile Lys Phe Val Asp Val Gly Gly His 
        755                 760                 765             


Ser His Gly Cys Thr Pro Leu Ala Ser Ala Pro Thr Arg Ser Asp Ser 
    770                 775                 780                 


Phe Met Met Val Lys Ser Pro Ser Ala Pro Met Ala Gly Glu Pro Val 
785                 790                 795                 800 


Arg Pro Ser Cys Pro Pro Ser Asp Leu Leu Tyr Gly Leu Glu Gln Ala 
                805                 810                 815     


Pro Pro Asn Thr Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr 
            820                 825                 830         


Ser Gly Ser Gln Asn Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln 
        835                 840                 845             


Phe Asp Thr Glu Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser Glu 
    850                 855                 860                 


Ala Ala Asp Gly Ser Ser Thr Leu Gly Gly Gly Ala Gly Thr Met Gly 
865                 870                 875                 880 


Leu Ser Ala Arg Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro Asp 
                885                 890                 895     


Tyr Arg Gln Asn Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn 
            900                 905                 910         


Ala Ala Gly Lys Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn 
        915                 920                 925             


Lys Lys Lys Ser Gly Lys Lys Glu Lys Lys 
    930                 935             


<210>  4522
<211>  944
<212>  PRT
<213>  Homo sapiens

<400>  4522

Met Gly Pro Lys Thr Leu Pro Gln Leu Ala Gly Lys Trp Gln Val Leu 
1               5                   10                  15      


Cys Met Leu Ser Leu Cys Cys Trp Gly Trp Val Ser Gly Gln Leu Arg 
            20                  25                  30          


Tyr Ser Val Val Glu Glu Ser Glu Pro Gly Thr Leu Val Gly Asn Val 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Lys Met Thr Asp Leu Leu Ser Arg Arg Leu 
    50                  55                  60                  


Gln Leu Gly Ser Glu Glu Asn Gly Arg Tyr Phe Ser Leu Ser Leu Met 
65                  70                  75                  80  


Ser Gly Ala Leu Ala Val Asn Gln Lys Ile Asp Arg Glu Ser Leu Cys 
                85                  90                  95      


Gly Ala Ser Thr Ser Cys Leu Leu Pro Val Gln Val Val Thr Glu His 
            100                 105                 110         


Pro Leu Glu Leu Ile Arg Val Glu Val Glu Ile Leu Asp Leu Asn Asp 
        115                 120                 125             


Asn Ser Pro Ser Phe Ala Thr Pro Glu Arg Glu Met Arg Ile Ser Glu 
    130                 135                 140                 


Ser Ala Ala Ser Gly Ala Arg Phe Pro Leu Asp Ser Ala Gln Asp Pro 
145                 150                 155                 160 


Asp Val Gly Thr Asn Thr Val Ser Phe Tyr Thr Leu Ser Pro Asn Ser 
                165                 170                 175     


His Phe Ser Leu Asn Val Lys Thr Leu Lys Asp Gly Lys Pro Phe Pro 
            180                 185                 190         


Glu Leu Val Leu Glu Gln Gln Leu Asp Arg Glu Ala Gln Ala Arg His 
        195                 200                 205             


Gln Leu Val Leu Thr Ala Val Asp Gly Gly Thr Pro Ala Arg Ser Gly 
    210                 215                 220                 


Thr Thr Leu Ile Ser Val Ile Val Leu Asp Ile Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Thr Phe Gln Ser Ser Val Leu Arg Val Gly Ile Pro Glu Asn Ala Pro 
                245                 250                 255     


Ile Gly Thr Leu Leu Leu Arg Leu Asn Ala Thr Asp Pro Asp Glu Gly 
            260                 265                 270         


Thr Asn Gly Gln Leu Asp Tyr Ser Phe Gly Asp His Thr Ser Glu Ala 
        275                 280                 285             


Val Arg Asn Leu Phe Gly Leu Asp Pro Ser Ser Gly Ala Ile His Val 
    290                 295                 300                 


Leu Gly Pro Ile Asp Phe Glu Glu Ser Arg Phe Tyr Glu Ile His Ala 
305                 310                 315                 320 


Arg Ala Arg Asp Gln Gly Gln Pro Ala Met Glu Gly His Cys Val Ile 
                325                 330                 335     


Gln Val Asp Val Gly Asp Val Asn Asp Asn Ala Pro Glu Val Leu Leu 
            340                 345                 350         


Ala Ser Leu Ala Asn Pro Val Leu Glu Ser Thr Pro Val Gly Thr Val 
        355                 360                 365             


Val Gly Leu Phe Asn Val Arg Asp Arg Asp Ser Gly Arg Asn Gly Glu 
    370                 375                 380                 


Val Ser Leu Asp Ile Ser Pro Asp Leu Pro Phe Gln Ile Lys Pro Ser 
385                 390                 395                 400 


Glu Asn His Tyr Ser Leu Leu Thr Ser Gln Pro Leu Asp Arg Glu Ala 
                405                 410                 415     


Thr Ser His Tyr Ile Ile Glu Leu Leu Ala Ser Asp Ala Gly Ser Pro 
            420                 425                 430         


Ser Leu His Lys His Leu Thr Ile Arg Leu Asn Ile Ser Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Arg Phe Asn Gln Gln Leu Tyr Thr Ala Tyr Ile Leu 
    450                 455                 460                 


Glu Asn Arg Pro Pro Gly Ser Leu Leu Cys Thr Val Ala Ala Ser Asp 
465                 470                 475                 480 


Pro Asp Thr Gly Asp Asn Ala Arg Leu Thr Tyr Ser Ile Val Gly Asn 
                485                 490                 495     


Gln Val Gln Gly Ala Pro Ala Ser Ser Phe Val Tyr Val Asn Pro Glu 
            500                 505                 510         


Asp Gly Arg Ile Phe Ala Gln Arg Thr Phe Asp Tyr Glu Leu Leu Gln 
        515                 520                 525             


Met Leu Gln Ile Val Val Gly Val Arg Asp Ser Gly Ser Pro Pro Leu 
    530                 535                 540                 


His Ala Asn Thr Ser Leu His Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Val Leu His Pro Arg Pro Asp Trp Glu His Ser Ala Pro 
                565                 570                 575     


Gln Arg Leu Pro Arg Ser Ala Pro Pro Gly Ser Leu Val Thr Lys Val 
            580                 585                 590         


Thr Ala Val Asp Ala Asp Ala Gly His Asn Ala Trp Leu Ser Tyr Ser 
        595                 600                 605             


Leu Leu Pro Gln Ser Thr Ala Pro Gly Leu Phe Leu Val Ser Thr His 
    610                 615                 620                 


Thr Gly Glu Val Arg Thr Ala Arg Ala Leu Leu Glu Asp Asp Ser Asp 
625                 630                 635                 640 


Thr Gln Gln Val Val Val Leu Val Arg Asp Asn Gly Asp Pro Ser Leu 
                645                 650                 655     


Ser Ser Thr Ala Thr Val Leu Leu Val Leu Glu Asp Glu Asp Pro Glu 
            660                 665                 670         


Glu Met Pro Lys Ser Ser Asp Phe Leu Ile His Pro Pro Glu Arg Ser 
        675                 680                 685             


Asp Leu Thr Leu Tyr Leu Ile Val Ala Leu Ala Thr Val Ser Leu Leu 
    690                 695                 700                 


Ser Leu Val Thr Phe Thr Phe Leu Ser Ala Lys Cys Leu Gln Gly Asn 
705                 710                 715                 720 


Ala Asp Gly Asp Gly Gly Gly Gly Gln Cys Cys Arg Arg Gln Asp Ser 
                725                 730                 735     


Pro Ser Pro Asp Phe Tyr Lys Gln Ser Ser Pro Asn Leu Gln Val Ser 
            740                 745                 750         


Ser Asp Gly Thr Leu Lys Tyr Met Glu Val Thr Leu Arg Pro Thr Asp 
        755                 760                 765             


Ser Gln Ser His Cys Tyr Arg Thr Cys Phe Ser Pro Ala Ser Asp Gly 
    770                 775                 780                 


Ser Asp Phe Thr Phe Leu Arg Pro Leu Ser Val Gln Gln Pro Thr Ala 
785                 790                 795                 800 


Leu Ala Leu Glu Pro Asp Ala Ile Arg Ser Arg Ser Asn Thr Leu Arg 
                805                 810                 815     


Glu Arg Ser Gln Gln Ala Pro Pro Asn Thr Asp Trp Arg Phe Ser Gln 
            820                 825                 830         


Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly Asp Asp Thr Gly 
        835                 840                 845             


Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu Gln Ala Met Ile 
    850                 855                 860                 


Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser Thr Leu Gly Gly 
865                 870                 875                 880 


Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly Pro Gln Phe Thr 
                885                 890                 895     


Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr Ile Pro Gly Ser 
            900                 905                 910         


Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp Gly Lys Ala Pro 
        915                 920                 925             


Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys Lys Glu Lys Lys 
    930                 935                 940                 


<210>  4523
<211>  800
<212>  PRT
<213>  Homo sapiens

<400>  4523

Met Ala Val Arg Glu Leu Cys Phe Pro Arg Gln Arg Gln Val Leu Phe 
1               5                   10                  15      


Leu Phe Leu Phe Trp Gly Val Ser Leu Ala Gly Ser Gly Phe Gly Arg 
            20                  25                  30          


Tyr Ser Val Thr Glu Glu Thr Glu Lys Gly Ser Phe Val Val Asn Leu 
        35                  40                  45              


Ala Lys Asp Leu Gly Leu Ala Glu Gly Glu Leu Ala Ala Arg Gly Thr 
    50                  55                  60                  


Arg Val Val Ser Asp Asp Asn Lys Gln Tyr Leu Leu Leu Asp Ser His 
65                  70                  75                  80  


Thr Gly Asn Leu Leu Thr Asn Glu Lys Leu Asp Arg Glu Lys Leu Cys 
                85                  90                  95      


Gly Pro Lys Glu Pro Cys Met Leu Tyr Phe Gln Ile Leu Met Asp Asp 
            100                 105                 110         


Pro Phe Gln Ile Tyr Arg Ala Glu Leu Arg Val Arg Asp Ile Asn Asp 
        115                 120                 125             


His Ala Pro Val Phe Gln Asp Lys Glu Thr Val Leu Lys Ile Ser Glu 
    130                 135                 140                 


Asn Thr Ala Glu Gly Thr Ala Phe Arg Leu Glu Arg Ala Gln Asp Pro 
145                 150                 155                 160 


Asp Gly Gly Leu Asn Gly Ile Gln Asn Tyr Thr Ile Ser Pro Asn Ser 
                165                 170                 175     


Phe Phe His Ile Asn Ile Ser Gly Gly Asp Glu Gly Met Ile Tyr Pro 
            180                 185                 190         


Glu Leu Val Leu Asp Lys Ala Leu Asp Arg Glu Glu Gln Gly Glu Leu 
        195                 200                 205             


Ser Leu Thr Leu Thr Ala Leu Asp Gly Gly Ser Pro Ser Arg Ser Gly 
    210                 215                 220                 


Thr Ser Thr Val Arg Ile Val Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Gln Phe Ala Gln Ala Leu Tyr Glu Thr Gln Ala Pro Glu Asn Ser Pro 
                245                 250                 255     


Ile Gly Phe Leu Ile Val Lys Val Trp Ala Glu Asp Val Asp Ser Gly 
            260                 265                 270         


Val Asn Ala Glu Val Ser Tyr Ser Phe Phe Asp Ala Ser Glu Asn Ile 
        275                 280                 285             


Arg Thr Thr Phe Gln Ile Asn Pro Phe Ser Gly Glu Ile Phe Leu Arg 
    290                 295                 300                 


Glu Leu Leu Asp Tyr Glu Leu Val Asn Ser Tyr Lys Ile Asn Ile Gln 
305                 310                 315                 320 


Ala Met Asp Gly Gly Gly Leu Ser Ala Arg Cys Arg Val Leu Val Glu 
                325                 330                 335     


Val Leu Asp Thr Asn Asp Asn Pro Pro Glu Leu Ile Val Ser Ser Phe 
            340                 345                 350         


Ser Asn Ser Val Ala Glu Asn Ser Pro Glu Thr Pro Leu Ala Val Phe 
        355                 360                 365             


Lys Ile Asn Asp Arg Asp Ser Gly Glu Asn Gly Lys Met Val Cys Tyr 
    370                 375                 380                 


Ile Gln Glu Asn Leu Pro Phe Leu Leu Lys Pro Ser Val Glu Asn Phe 
385                 390                 395                 400 


Tyr Ile Leu Ile Thr Glu Gly Ala Leu Asp Arg Glu Ile Arg Ala Glu 
                405                 410                 415     


Tyr Asn Ile Thr Ile Thr Val Thr Asp Leu Gly Thr Pro Arg Leu Lys 
            420                 425                 430         


Thr Glu His Asn Ile Thr Val Leu Val Ser Asp Val Asn Asp Asn Ala 
        435                 440                 445             


Pro Ala Phe Thr Gln Thr Ser Tyr Thr Leu Phe Val Arg Glu Asn Asn 
    450                 455                 460                 


Ser Pro Ala Leu His Ile Gly Ser Val Ser Ala Thr Asp Arg Asp Ser 
465                 470                 475                 480 


Gly Thr Asn Ala Gln Val Thr Tyr Ser Leu Leu Pro Pro Gln Asp Pro 
                485                 490                 495     


His Leu Pro Leu Ala Ser Leu Val Ser Ile Asn Ala Asp Asn Gly His 
            500                 505                 510         


Leu Phe Ala Leu Arg Ser Leu Asp Tyr Glu Ala Leu Gln Ala Phe Glu 
        515                 520                 525             


Phe Arg Val Gly Ala Thr Asp Arg Gly Ser Pro Ala Leu Ser Arg Glu 
    530                 535                 540                 


Ala Leu Val Arg Val Leu Val Leu Asp Ala Asn Asp Asn Ser Pro Phe 
545                 550                 555                 560 


Val Leu Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu Leu Val 
                565                 570                 575     


Pro Arg Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val 
            580                 585                 590         


Asp Gly Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu Lys 
        595                 600                 605             


Ala Thr Glu Pro Gly Leu Phe Gly Val Trp Ala His Asn Gly Glu Val 
    610                 615                 620                 


Arg Thr Ala Arg Leu Leu Ser Glu Arg Asp Ala Ala Lys His Arg Leu 
625                 630                 635                 640 


Val Val Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr Ala 
                645                 650                 655     


Thr Leu His Leu Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr Leu Pro 
            660                 665                 670         


Leu Pro Glu Ala Ala Pro Ala Gln Ala Gln Ala Glu Ala Asp Leu Leu 
        675                 680                 685             


Thr Val Tyr Leu Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu 
    690                 695                 700                 


Leu Ser Val Leu Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg 
705                 710                 715                 720 


Ala Ala Ser Val Gly Arg Cys Ser Val Pro Glu Gly Pro Phe Pro Gly 
                725                 730                 735     


His Leu Val Asp Val Arg Gly Ala Glu Thr Leu Ser Gln Ser Tyr Gln 
            740                 745                 750         


Tyr Glu Val Cys Leu Thr Gly Gly Pro Gly Thr Ser Glu Phe Lys Phe 
        755                 760                 765             


Leu Lys Pro Val Ile Ser Asp Ile Gln Ala Gln Gly Pro Gly Arg Lys 
    770                 775                 780                 


Gly Glu Glu Asn Ser Thr Phe Arg Asn Ser Phe Gly Phe Asn Ile Gln 
785                 790                 795                 800 


<210>  4524
<211>  797
<212>  PRT
<213>  Homo sapiens

<400>  4524

Met Glu Asn Gln Gly Thr Arg Thr Gln Gln Ile Arg Gln Val Leu Leu 
1               5                   10                  15      


Leu Phe Val Leu Leu Gly Met Ser Gln Ala Gly Ser Glu Thr Trp Ser 
            20                  25                  30          


Phe Ser Val Ala Glu Glu Met Gln Ser Gly Ser Phe Val Gly Asn Leu 
        35                  40                  45              


Ala Lys Asp Leu Gly Leu Lys Val Arg Glu Leu Ser Ser Arg Gly Ala 
    50                  55                  60                  


Arg Val Val Ser Asn Asp Lys Lys Gln Arg Leu Gln Leu Asp Ile Asn 
65                  70                  75                  80  


Thr Gly Asp Leu Leu Leu Ser Glu Thr Leu Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Ser Ile Glu Pro Cys Val Leu His Leu Gln Val Leu Met Gln Asn 
            100                 105                 110         


Pro Thr Gln Phe Leu Gln Ile Glu Leu Gln Val Arg Asp Ile Asn Asp 
        115                 120                 125             


His Ser Pro Ile Phe Ser Glu Lys Gln Met Leu Leu Glu Ile Pro Glu 
    130                 135                 140                 


Asn Ser Pro Val Gly Ala Val Phe Leu Leu Glu Ser Ala Lys Asp Leu 
145                 150                 155                 160 


Asp Val Gly Ile Asn Ala Val Lys Ser Tyr Thr Ile Ser Pro Asn Ser 
                165                 170                 175     


His Phe His Ile Lys Met Arg Val Ile Pro Asp Asn Arg Lys Tyr Pro 
            180                 185                 190         


Glu Leu Val Leu Asp Lys Ala Leu Asp Tyr Glu Glu Leu Pro Glu Leu 
        195                 200                 205             


Ser Phe Ile Leu Ser Ala Leu Asp Gly Gly Ser Pro Pro Arg Ser Gly 
    210                 215                 220                 


Thr Ala Leu Val Arg Val Val Val Val Asp Ile Asn Asp Asn Ser Pro 
225                 230                 235                 240 


Glu Phe Glu Gln Ala Phe Tyr Glu Val Lys Ile Arg Glu Asn Ser Ile 
                245                 250                 255     


Leu Gly Ser Leu Ile Leu Ile Val Ser Ala Trp Asp Leu Asp Ser Gly 
            260                 265                 270         


Thr Asn Gly Glu Ile Cys Tyr Thr Phe Ser His Ala Ser Glu Asp Ile 
        275                 280                 285             


Arg Lys Thr Phe Glu Ile Asn Gln Lys Ser Gly Glu Ile Thr Leu Arg 
    290                 295                 300                 


Ala Pro Leu Asp Phe Glu Thr Ile Glu Ser Tyr Ser Ile Ile Ile Gln 
305                 310                 315                 320 


Ala Thr Asp Gly Gly Gly Leu Phe Gly Lys Ser Thr Val Ile Ile His 
                325                 330                 335     


Val Ile Asp Val Asn Asp Asn Ala Pro Glu Ile Thr Val Ser Ser Ile 
            340                 345                 350         


Thr Ser Pro Ile Pro Glu Asn Thr Pro Glu Thr Val Val Met Val Phe 
        355                 360                 365             


Ser Ile Gln Asp Ile Asp Ser Gly Asp Asn Gly Arg Ile Val Cys Ser 
    370                 375                 380                 


Ile Pro Glu Asp Leu Pro Phe Val Leu Lys Ser Ser Val Glu Asn Tyr 
385                 390                 395                 400 


Tyr Thr Leu Glu Thr Glu Arg Pro Leu Asp Arg Glu Ser Thr Ala Glu 
                405                 410                 415     


Tyr Asn Ile Thr Ile Thr Val Thr Asp Leu Gly Ile Pro Arg Leu Lys 
            420                 425                 430         


Thr Glu His Asn Thr Thr Val Leu Val Ser Asp Val Asn Asp Asn Ala 
        435                 440                 445             


Pro Thr Phe Thr Gln Thr Ser Tyr Thr Leu Phe Val Arg Glu Asn Asn 
    450                 455                 460                 


Ser Pro Ala Leu His Ile Gly Ser Val Ser Ala Thr Asp Arg Asp Ser 
465                 470                 475                 480 


Gly Thr Asn Ala Gln Val Asn Tyr Ser Leu Leu Pro Pro Gln Asp Leu 
                485                 490                 495     


His Leu Pro Leu Ala Ser Leu Val Ser Ile Asn Thr Asp Asn Gly His 
            500                 505                 510         


Leu Phe Ala Leu Arg Ser Leu Asp Tyr Glu Ala Leu Gln Ala Phe Asp 
        515                 520                 525             


Phe Arg Val Gly Ala Thr Asp Arg Gly Ser Pro Ala Leu Ser Ser Glu 
    530                 535                 540                 


Ala Leu Val Arg Val Leu Val Leu Asp Ala Asn Asp Asn Ser Pro Phe 
545                 550                 555                 560 


Val Leu Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu Leu Val 
                565                 570                 575     


Pro Arg Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val 
            580                 585                 590         


Asp Gly Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu Lys 
        595                 600                 605             


Ala Thr Glu Pro Gly Leu Phe Gly Val Trp Ala His Asn Gly Glu Val 
    610                 615                 620                 


Arg Thr Ala Arg Leu Leu Ser Glu Arg Asp Ala Ala Lys His Arg Leu 
625                 630                 635                 640 


Val Val Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr Ala 
                645                 650                 655     


Thr Leu Gln Val Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr Leu Pro 
            660                 665                 670         


Leu Pro Glu Ala Ala Pro Ala Gln Ala Gln Ala Asp Ser Leu Thr Val 
        675                 680                 685             


Tyr Leu Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu Phe Ser 
    690                 695                 700                 


Val Leu Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg Ala Ala 
705                 710                 715                 720 


Ser Val Gly Ser Cys Ser Val Pro Lys Gly Pro Phe Pro Gly His Leu 
                725                 730                 735     


Val Asp Val Ser Gly Thr Gly Thr Leu Ser Gln Ser Tyr Gln Tyr Glu 
            740                 745                 750         


Val Cys Leu Thr Gly Gly Ser Glu Thr Asn Glu Phe Lys Phe Leu Lys 
        755                 760                 765             


Pro Val Ile Pro Asn Ile Gln Ala Lys Gly Leu Gly Lys Asn Ser Glu 
    770                 775                 780                 


Glu Asn Ser Thr Phe Arg Asn Ser Phe Gly Phe Asn Phe 
785                 790                 795         


<210>  4525
<211>  795
<212>  PRT
<213>  Homo sapiens

<400>  4525

Met Glu Asn Gly Gly Ala Gly Thr Leu Gln Ile Arg Gln Val Leu Leu 
1               5                   10                  15      


Phe Phe Val Leu Leu Gly Met Ser Gln Ala Gly Ser Glu Thr Gly Asn 
            20                  25                  30          


Phe Leu Val Met Glu Glu Leu Gln Ser Gly Ser Phe Val Gly Asn Leu 
        35                  40                  45              


Ala Lys Thr Leu Gly Leu Glu Val Ser Glu Leu Ser Ser Arg Gly Ala 
    50                  55                  60                  


Arg Val Val Ser Asn Asp Asn Lys Glu Cys Leu Gln Leu Asp Thr Asn 
65                  70                  75                  80  


Thr Gly Asp Leu Leu Leu Arg Glu Met Leu Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Ser Asn Glu Pro Cys Val Leu Tyr Phe Gln Val Leu Met Lys Asn 
            100                 105                 110         


Pro Thr Gln Phe Leu Gln Ile Glu Leu Gln Val Arg Asp Ile Asn Asp 
        115                 120                 125             


His Ser Pro Val Phe Leu Glu Lys Glu Met Leu Leu Glu Ile Pro Glu 
    130                 135                 140                 


Asn Ser Pro Val Gly Ala Val Phe Leu Leu Glu Ser Ala Lys Asp Leu 
145                 150                 155                 160 


Asp Val Gly Ile Asn Ala Val Lys Ser Tyr Thr Ile Asn Pro Asn Ser 
                165                 170                 175     


His Phe His Val Lys Ile Arg Val Asn Pro Asp Asn Arg Lys Tyr Pro 
            180                 185                 190         


Glu Leu Val Leu Asp Lys Ala Leu Asp Tyr Glu Glu Arg Pro Glu Leu 
        195                 200                 205             


Ser Phe Ile Leu Thr Ala Leu Asp Gly Gly Ser Pro Pro Arg Ser Gly 
    210                 215                 220                 


Thr Ala Leu Val Arg Val Val Val Val Asp Ile Asn Asp Asn Ser Pro 
225                 230                 235                 240 


Glu Phe Glu Gln Ala Phe Tyr Glu Val Lys Ile Leu Glu Asn Ser Ile 
                245                 250                 255     


Leu Gly Ser Leu Val Val Thr Val Ser Ala Trp Asp Leu Asp Ser Gly 
            260                 265                 270         


Thr Asn Ser Glu Leu Ser Tyr Thr Phe Ser His Ala Ser Glu Asp Ile 
        275                 280                 285             


Arg Lys Thr Phe Glu Ile Asn Gln Lys Ser Gly Asp Ile Thr Leu Thr 
    290                 295                 300                 


Ala Pro Leu Asp Phe Glu Ala Ile Glu Ser Tyr Ser Ile Ile Ile Gln 
305                 310                 315                 320 


Ala Thr Asp Gly Gly Gly Leu Phe Gly Lys Ser Thr Val Arg Ile Gln 
                325                 330                 335     


Val Met Asp Val Asn Asp Asn Ala Pro Glu Ile Thr Val Ser Ser Ile 
            340                 345                 350         


Thr Ser Pro Ile Pro Glu Asn Thr Pro Glu Thr Val Val Met Val Phe 
        355                 360                 365             


Arg Ile Arg Asp Arg Asp Ser Gly Asp Asn Gly Lys Met Val Cys Ser 
    370                 375                 380                 


Ile Pro Glu Asp Ile Pro Phe Val Leu Lys Ser Ser Val Asn Asn Tyr 
385                 390                 395                 400 


Tyr Thr Leu Glu Thr Glu Arg Pro Leu Asp Arg Glu Ser Arg Ala Glu 
                405                 410                 415     


Tyr Asn Ile Thr Ile Thr Val Thr Asp Leu Gly Thr Pro Arg Leu Lys 
            420                 425                 430         


Thr Glu His Asn Ile Thr Val Leu Val Ser Asp Val Asn Asp Asn Ala 
        435                 440                 445             


Pro Ala Phe Thr Gln Thr Ser Tyr Ala Leu Phe Val Arg Glu Asn Asn 
    450                 455                 460                 


Ser Pro Ala Leu His Ile Gly Ser Ile Ser Ala Thr Asp Arg Asp Ser 
465                 470                 475                 480 


Gly Thr Asn Ala Gln Val Asn Tyr Ser Leu Leu Pro Ser Gln Asp Pro 
                485                 490                 495     


His Leu Pro Leu Ala Ser Leu Val Ser Ile Asn Ala Asp Asn Gly His 
            500                 505                 510         


Leu Phe Ala Leu Arg Ser Leu Asp Tyr Glu Ala Leu Gln Gly Phe Gln 
        515                 520                 525             


Phe Arg Val Gly Ala Thr Asp His Gly Ser Pro Ala Leu Ser Ser Glu 
    530                 535                 540                 


Ala Leu Val Arg Val Leu Val Leu Asp Ala Asn Asp Asn Ser Pro Phe 
545                 550                 555                 560 


Val Leu Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu Leu Val 
                565                 570                 575     


Pro Trp Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val 
            580                 585                 590         


Asp Gly Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu Lys 
        595                 600                 605             


Ala Thr Glu Pro Gly Leu Phe Gly Val Trp Ala His Asn Gly Glu Val 
    610                 615                 620                 


Arg Thr Ala Arg Leu Leu Ser Glu Arg Asp Ala Ala Lys His Arg Leu 
625                 630                 635                 640 


Val Val Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr Ala 
                645                 650                 655     


Thr Leu His Val Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr Leu Pro 
            660                 665                 670         


Leu Pro Glu Ala Ala Pro Ala Gln Ala Gln Ala Asp Ser Leu Thr Val 
        675                 680                 685             


Tyr Leu Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu Phe Ser 
    690                 695                 700                 


Val Leu Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg Ala Ala 
705                 710                 715                 720 


Pro Val Gly Arg Cys Ser Val Pro Glu Gly Pro Phe Pro Gly His Leu 
                725                 730                 735     


Val Asp Val Ser Gly Thr Gly Thr Leu Ser Gln Ser Tyr His Tyr Glu 
            740                 745                 750         


Val Cys Val Thr Gly Gly Ser Arg Ser Asn Lys Phe Lys Phe Leu Lys 
        755                 760                 765             


Pro Ile Ile Pro Asn Phe Leu Pro Gln Ser Thr Gly Ser Glu Val Glu 
    770                 775                 780                 


Glu Asn Pro Pro Phe Gln Asn Asn Leu Gly Phe 
785                 790                 795 


<210>  4526
<211>  797
<212>  PRT
<213>  Homo sapiens

<400>  4526

Met Glu Asn Gln Gly Thr Arg Thr Gln Gln Ile Arg Gln Val Leu Leu 
1               5                   10                  15      


Leu Phe Val Leu Leu Gly Met Ser Gln Ala Gly Ser Glu Thr Trp Ser 
            20                  25                  30          


Phe Ser Val Ala Glu Glu Met Gln Ser Gly Ser Phe Val Gly Asn Leu 
        35                  40                  45              


Ala Lys Asp Leu Gly Leu Lys Val Arg Glu Leu Ser Ser Arg Gly Ala 
    50                  55                  60                  


Arg Val Val Ser Asn Asp Lys Lys Gln Arg Leu Gln Leu Asp Ile Asn 
65                  70                  75                  80  


Thr Gly Asp Leu Leu Leu Ser Glu Thr Leu Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Ser Ile Glu Pro Cys Val Leu His Leu Gln Val Leu Met Gln Asn 
            100                 105                 110         


Pro Thr Gln Phe Leu Gln Ile Glu Leu Gln Val Arg Asp Ile Asn Asp 
        115                 120                 125             


His Ser Pro Ile Phe Ser Glu Lys Gln Met Leu Leu Glu Ile Pro Glu 
    130                 135                 140                 


Asn Ser Pro Val Gly Ala Val Phe Leu Leu Glu Ser Ala Lys Asp Leu 
145                 150                 155                 160 


Asp Val Gly Ile Asn Ala Val Lys Ser Tyr Thr Ile Ser Pro Asn Ser 
                165                 170                 175     


His Phe His Ile Lys Met Arg Val Ile Pro Asp Asn Arg Lys Tyr Pro 
            180                 185                 190         


Glu Leu Val Leu Asp Lys Ala Leu Asp Tyr Glu Glu Leu Pro Glu Leu 
        195                 200                 205             


Ser Phe Ile Leu Ser Ala Leu Asp Gly Gly Ser Pro Pro Arg Ser Gly 
    210                 215                 220                 


Thr Ala Leu Val Arg Val Val Val Val Asp Ile Asn Asp Asn Ser Pro 
225                 230                 235                 240 


Glu Phe Glu Gln Ala Phe Tyr Glu Val Lys Ile Arg Glu Asn Ser Ile 
                245                 250                 255     


Leu Gly Ser Leu Ile Leu Ile Val Ser Ala Trp Asp Leu Asp Ser Gly 
            260                 265                 270         


Thr Asn Gly Glu Ile Cys Tyr Thr Phe Ser His Ala Ser Glu Asp Ile 
        275                 280                 285             


Arg Lys Thr Phe Glu Ile Asn Gln Lys Ser Gly Glu Ile Thr Leu Arg 
    290                 295                 300                 


Ala Pro Leu Asp Phe Glu Thr Ile Glu Ser Tyr Ser Ile Ile Ile Gln 
305                 310                 315                 320 


Ala Thr Asp Gly Gly Gly Leu Phe Gly Lys Ser Thr Val Ile Ile His 
                325                 330                 335     


Val Ile Asp Val Asn Asp Asn Ala Pro Glu Ile Thr Val Ser Ser Ile 
            340                 345                 350         


Thr Ser Pro Ile Pro Glu Asn Thr Pro Glu Thr Val Val Met Val Phe 
        355                 360                 365             


Ser Ile Gln Asp Ile Asp Ser Gly Asp Asn Gly Arg Ile Val Cys Ser 
    370                 375                 380                 


Ile Pro Glu Asp Leu Pro Phe Val Leu Lys Ser Ser Val Glu Asn Tyr 
385                 390                 395                 400 


Tyr Thr Leu Glu Thr Glu Arg Pro Leu Asp Arg Glu Ser Thr Ala Glu 
                405                 410                 415     


Tyr Asn Ile Thr Ile Thr Val Thr Asp Leu Gly Ile Pro Arg Leu Lys 
            420                 425                 430         


Thr Glu His Asn Thr Thr Val Leu Val Ser Asp Val Asn Asp Asn Ala 
        435                 440                 445             


Pro Thr Phe Thr Gln Thr Ser Tyr Thr Leu Phe Val Arg Glu Asn Asn 
    450                 455                 460                 


Ser Pro Ala Leu His Ile Gly Ser Val Ser Ala Thr Asp Arg Asp Ser 
465                 470                 475                 480 


Gly Thr Asn Ala Gln Val Asn Tyr Ser Leu Leu Pro Pro Gln Asp Leu 
                485                 490                 495     


His Leu Pro Leu Ala Ser Leu Val Ser Ile Asn Thr Asp Asn Gly His 
            500                 505                 510         


Leu Phe Ala Leu Arg Ser Leu Asp Tyr Glu Ala Leu Gln Ala Phe Asp 
        515                 520                 525             


Phe Arg Val Gly Ala Thr Asp Arg Gly Ser Pro Ala Leu Ser Ser Glu 
    530                 535                 540                 


Ala Leu Val Arg Val Leu Val Leu Asp Ala Asn Asp Asn Ser Pro Phe 
545                 550                 555                 560 


Val Leu Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu Leu Val 
                565                 570                 575     


Pro Arg Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val 
            580                 585                 590         


Asp Gly Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu Lys 
        595                 600                 605             


Ala Thr Glu Pro Gly Leu Phe Gly Val Trp Ala His Asn Gly Glu Val 
    610                 615                 620                 


Arg Thr Ala Arg Leu Leu Ser Glu Arg Asp Ala Ala Lys His Arg Leu 
625                 630                 635                 640 


Val Val Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr Ala 
                645                 650                 655     


Thr Leu Gln Val Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr Leu Pro 
            660                 665                 670         


Leu Pro Glu Ala Ala Pro Ala Gln Ala Gln Ala Asp Ser Leu Thr Val 
        675                 680                 685             


Tyr Leu Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu Phe Ser 
    690                 695                 700                 


Val Leu Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg Ala Ala 
705                 710                 715                 720 


Ser Val Gly Ser Cys Ser Val Pro Lys Gly Pro Phe Pro Gly His Leu 
                725                 730                 735     


Val Asp Val Ser Gly Thr Gly Thr Leu Ser Gln Ser Tyr Gln Tyr Glu 
            740                 745                 750         


Val Cys Leu Thr Gly Gly Ser Glu Thr Asn Glu Phe Lys Phe Leu Lys 
        755                 760                 765             


Pro Val Ile Pro Asn Ile Gln Ala Lys Gly Leu Gly Lys Asn Ser Glu 
    770                 775                 780                 


Glu Asn Ser Thr Phe Arg Asn Ser Phe Gly Phe Asn Phe 
785                 790                 795         


<210>  4527
<211>  795
<212>  PRT
<213>  Homo sapiens

<400>  4527

Met Glu Asn Gly Gly Ala Gly Thr Leu Gln Ile Arg Gln Val Leu Leu 
1               5                   10                  15      


Phe Phe Val Leu Leu Gly Met Ser Gln Ala Gly Ser Glu Thr Gly Asn 
            20                  25                  30          


Phe Leu Val Met Glu Glu Leu Gln Ser Gly Ser Phe Val Gly Asn Leu 
        35                  40                  45              


Ala Lys Thr Leu Gly Leu Glu Val Ser Glu Leu Ser Ser Arg Gly Ala 
    50                  55                  60                  


Arg Val Val Ser Asn Asp Asn Lys Glu Cys Leu Gln Leu Asp Thr Asn 
65                  70                  75                  80  


Thr Gly Asp Leu Leu Leu Arg Glu Met Leu Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Ser Asn Glu Pro Cys Val Leu Tyr Phe Gln Val Leu Met Lys Asn 
            100                 105                 110         


Pro Thr Gln Phe Leu Gln Ile Glu Leu Gln Val Arg Asp Ile Asn Asp 
        115                 120                 125             


His Ser Pro Val Phe Leu Glu Lys Glu Met Leu Leu Glu Ile Pro Glu 
    130                 135                 140                 


Asn Ser Pro Val Gly Ala Val Phe Leu Leu Glu Ser Ala Lys Asp Leu 
145                 150                 155                 160 


Asp Val Gly Ile Asn Ala Val Lys Ser Tyr Thr Ile Asn Pro Asn Ser 
                165                 170                 175     


His Phe His Val Lys Ile Arg Val Asn Pro Asp Asn Arg Lys Tyr Pro 
            180                 185                 190         


Glu Leu Val Leu Asp Lys Ala Leu Asp Tyr Glu Glu Arg Pro Glu Leu 
        195                 200                 205             


Ser Phe Ile Leu Thr Ala Leu Asp Gly Gly Ser Pro Pro Arg Ser Gly 
    210                 215                 220                 


Thr Ala Leu Val Arg Val Val Val Val Asp Ile Asn Asp Asn Ser Pro 
225                 230                 235                 240 


Glu Phe Glu Gln Ala Phe Tyr Glu Val Lys Ile Leu Glu Asn Ser Ile 
                245                 250                 255     


Leu Gly Ser Leu Val Val Thr Val Ser Ala Trp Asp Leu Asp Ser Gly 
            260                 265                 270         


Thr Asn Ser Glu Leu Ser Tyr Thr Phe Ser His Ala Ser Glu Asp Ile 
        275                 280                 285             


Arg Lys Thr Phe Glu Ile Asn Gln Lys Ser Gly Asp Ile Thr Leu Thr 
    290                 295                 300                 


Ala Pro Leu Asp Phe Glu Ala Ile Glu Ser Tyr Ser Ile Ile Ile Gln 
305                 310                 315                 320 


Ala Thr Asp Gly Gly Gly Leu Phe Gly Lys Ser Thr Val Arg Ile Gln 
                325                 330                 335     


Val Met Asp Val Asn Asp Asn Ala Pro Glu Ile Thr Val Ser Ser Ile 
            340                 345                 350         


Thr Ser Pro Ile Pro Glu Asn Thr Pro Glu Thr Val Val Met Val Phe 
        355                 360                 365             


Arg Ile Arg Asp Arg Asp Ser Gly Asp Asn Gly Lys Met Val Cys Ser 
    370                 375                 380                 


Ile Pro Glu Asp Ile Pro Phe Val Leu Lys Ser Ser Val Asn Asn Tyr 
385                 390                 395                 400 


Tyr Thr Leu Glu Thr Glu Arg Pro Leu Asp Arg Glu Ser Arg Ala Glu 
                405                 410                 415     


Tyr Asn Ile Thr Ile Thr Val Thr Asp Leu Gly Thr Pro Arg Leu Lys 
            420                 425                 430         


Thr Glu His Asn Ile Thr Val Leu Val Ser Asp Val Asn Asp Asn Ala 
        435                 440                 445             


Pro Ala Phe Thr Gln Thr Ser Tyr Ala Leu Phe Val Arg Glu Asn Asn 
    450                 455                 460                 


Ser Pro Ala Leu His Ile Gly Ser Ile Ser Ala Thr Asp Arg Asp Ser 
465                 470                 475                 480 


Gly Thr Asn Ala Gln Val Asn Tyr Ser Leu Leu Pro Ser Gln Asp Pro 
                485                 490                 495     


His Leu Pro Leu Ala Ser Leu Val Ser Ile Asn Ala Asp Asn Gly His 
            500                 505                 510         


Leu Phe Ala Leu Arg Ser Leu Asp Tyr Glu Ala Leu Gln Gly Phe Gln 
        515                 520                 525             


Phe Arg Val Gly Ala Thr Asp His Gly Ser Pro Ala Leu Ser Ser Glu 
    530                 535                 540                 


Ala Leu Val Arg Val Leu Val Leu Asp Ala Asn Asp Asn Ser Pro Phe 
545                 550                 555                 560 


Val Leu Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu Leu Val 
                565                 570                 575     


Pro Trp Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val 
            580                 585                 590         


Asp Gly Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu Lys 
        595                 600                 605             


Ala Thr Glu Pro Gly Leu Phe Gly Val Trp Ala His Asn Gly Glu Val 
    610                 615                 620                 


Arg Thr Ala Arg Leu Leu Ser Glu Arg Asp Ala Ala Lys His Arg Leu 
625                 630                 635                 640 


Val Val Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr Ala 
                645                 650                 655     


Thr Leu His Val Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr Leu Pro 
            660                 665                 670         


Leu Pro Glu Ala Ala Pro Ala Gln Ala Gln Ala Asp Ser Leu Thr Val 
        675                 680                 685             


Tyr Leu Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu Phe Ser 
    690                 695                 700                 


Val Leu Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg Ala Ala 
705                 710                 715                 720 


Pro Val Gly Arg Cys Ser Val Pro Glu Gly Pro Phe Pro Gly His Leu 
                725                 730                 735     


Val Asp Val Ser Gly Thr Gly Thr Leu Ser Gln Ser Tyr His Tyr Glu 
            740                 745                 750         


Val Cys Val Thr Gly Gly Ser Arg Ser Asn Lys Phe Lys Phe Leu Lys 
        755                 760                 765             


Pro Ile Ile Pro Asn Phe Leu Pro Gln Ser Thr Gly Ser Glu Val Glu 
    770                 775                 780                 


Glu Asn Pro Pro Phe Gln Asn Asn Leu Gly Phe 
785                 790                 795 


<210>  4528
<211>  798
<212>  PRT
<213>  Homo sapiens

<400>  4528

Met Glu Ile Arg Gly Ala Leu Asp Leu Arg Lys Arg Gln Val Leu Ile 
1               5                   10                  15      


Phe Leu Val Leu Leu Gly Leu Ser Arg Ala Gly Thr Glu Ser Ala His 
            20                  25                  30          


Tyr Ser Val Ala Glu Glu Thr Glu Ile Gly Ser Phe Val Ala Asn Leu 
        35                  40                  45              


Ala Arg Asp Leu Gly Leu Gly Val Glu Glu Leu Ser Ser Arg Glu Ala 
    50                  55                  60                  


Arg Val Val Ser Asp Asp Asn Lys Lys Tyr Leu His Leu Asp Leu Leu 
65                  70                  75                  80  


Thr Gly Asn Leu Leu Leu Asn Glu Lys Leu Asp Arg Asp Glu Leu Cys 
                85                  90                  95      


Gly Ser Thr Glu Pro Cys Val Leu His Phe Gln Val Val Leu Glu Asn 
            100                 105                 110         


Pro Leu Gln Phe Phe Arg Phe Glu Leu Cys Val Lys Asp Ile Asn Asp 
        115                 120                 125             


His Ser Pro Thr Phe Leu Asp Lys Glu Ile Leu Ile Lys Ile Ser Glu 
    130                 135                 140                 


Gly Thr Thr Val Gly Ala Thr Phe Leu Met Glu Ser Ala Gln Asp Leu 
145                 150                 155                 160 


Asp Val Gly Ser Asn Ser Leu Gln Asn Tyr Thr Ile Ser Pro Asn Ser 
                165                 170                 175     


His Phe Tyr Ile Lys Ile Pro Asp Ser Ser Asp Arg Lys Ile Tyr Pro 
            180                 185                 190         


Glu Leu Val Leu Asp Arg Ala Leu Asp Tyr Glu Gln Glu Ala Glu Leu 
        195                 200                 205             


Arg Leu Thr Leu Thr Ala Val Asp Gly Gly Ser Pro Pro Lys Ser Gly 
    210                 215                 220                 


Thr Thr Leu Val Leu Ile Lys Val Leu Asp Ile Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Glu Phe Pro Gln Ser Leu Tyr Glu Val Gln Val Pro Glu Asp Arg Pro 
                245                 250                 255     


Leu Gly Ser Trp Ile Ala Thr Ile Ser Ala Lys Asp Leu Asp Ala Gly 
            260                 265                 270         


Asn Tyr Gly Lys Ile Ser Tyr Thr Phe Phe His Ala Ser Glu Asp Ile 
        275                 280                 285             


Arg Lys Thr Phe Glu Ile Asn Pro Ile Ser Gly Glu Val Asn Leu Arg 
    290                 295                 300                 


Ser Pro Leu Asp Phe Glu Val Ile Gln Ser Tyr Thr Ile Asn Ile Gln 
305                 310                 315                 320 


Ala Thr Asp Gly Gly Gly Leu Ser Gly Lys Cys Thr Leu Leu Val Lys 
                325                 330                 335     


Val Met Asp Ile Asn Asp Asn Pro Pro Glu Val Thr Ile Ser Ser Ile 
            340                 345                 350         


Thr Lys Arg Ile Pro Glu Asn Ala Ser Glu Thr Leu Val Ala Leu Phe 
        355                 360                 365             


Ser Ile Leu Asp Gln Asp Ser Gly Asp Asn Gly Arg Met Ile Cys Ser 
    370                 375                 380                 


Ile Gln Asp Asn Leu Pro Phe Phe Leu Lys Pro Thr Phe Lys Asn Phe 
385                 390                 395                 400 


Phe Thr Leu Val Ser Glu Lys Ala Leu Asp Arg Glu Ser Gln Ala Glu 
                405                 410                 415     


Tyr Asn Ile Thr Ile Thr Val Thr Asp Leu Gly Thr Pro Arg Leu Lys 
            420                 425                 430         


Thr Glu Tyr Asn Ile Thr Val Leu Leu Ser Asp Val Asn Asp Asn Ala 
        435                 440                 445             


Pro Thr Phe Thr Gln Thr Ser Tyr Thr Leu Phe Val Arg Glu Asn Asn 
    450                 455                 460                 


Ser Pro Ala Leu His Ile Gly Ser Val Ser Ala Thr Asp Arg Asp Ser 
465                 470                 475                 480 


Gly Thr Asn Ala Gln Val Asn Tyr Ser Leu Leu Pro Pro Gln Asp Arg 
                485                 490                 495     


His Leu Pro Leu Ala Ser Leu Val Ser Ile Asn Ala Asp Asn Gly His 
            500                 505                 510         


Leu Phe Ala Leu Arg Ser Leu Asp Tyr Glu Ala Leu Gln Glu Phe Glu 
        515                 520                 525             


Phe Arg Val Gly Ala Thr Asp Arg Gly Ser Pro Ala Leu Ser Ser Glu 
    530                 535                 540                 


Ala Leu Val Arg Val Leu Val Leu Asp Ala Asn Asp Asn Ser Pro Phe 
545                 550                 555                 560 


Val Leu Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu Leu Val 
                565                 570                 575     


Pro Arg Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val 
            580                 585                 590         


Asp Gly Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu Lys 
        595                 600                 605             


Ala Thr Glu Pro Gly Leu Phe Gly Val Trp Ala His Asn Gly Glu Val 
    610                 615                 620                 


Arg Thr Ala Arg Leu Leu Ser Glu Arg Asp Ala Ala Lys His Arg Leu 
625                 630                 635                 640 


Val Val Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr Ala 
                645                 650                 655     


Thr Leu His Val Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr Leu Pro 
            660                 665                 670         


Leu Pro Glu Ala Ala Pro Ala Gln Ala Gln Ala Asp Ser Leu Thr Val 
        675                 680                 685             


Tyr Leu Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu Phe Ser 
    690                 695                 700                 


Val Leu Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg Ala Ala 
705                 710                 715                 720 


Ser Val Gly Arg Cys Ser Val Pro Glu Gly Pro Phe Pro Gly His Leu 
                725                 730                 735     


Val Asp Val Ser Gly Thr Gly Thr Leu Ser Gln Ser Tyr Gln Tyr Glu 
            740                 745                 750         


Val Cys Leu Thr Gly Gly Ser Gly Thr Asn Glu Phe Lys Phe Leu Lys 
        755                 760                 765             


Pro Ile Ile Pro Asn Phe Gln Val His Asp Thr Gly Arg Asn Met Gly 
    770                 775                 780                 


Glu Ile Glu Asn Phe Arg Asn Ser Phe Gly Leu Asn Ile Gln 
785                 790                 795             


<210>  4529
<211>  798
<212>  PRT
<213>  Homo sapiens

<400>  4529

Met Glu Ile Arg Gly Ala Leu Asp Leu Arg Lys Arg Gln Val Leu Ile 
1               5                   10                  15      


Phe Leu Val Leu Leu Gly Leu Ser Arg Ala Gly Thr Glu Ser Ala His 
            20                  25                  30          


Tyr Ser Val Ala Glu Glu Thr Glu Ile Gly Ser Phe Val Ala Asn Leu 
        35                  40                  45              


Ala Arg Asp Leu Gly Leu Gly Val Glu Glu Leu Ser Ser Arg Glu Ala 
    50                  55                  60                  


Arg Val Val Ser Asp Asp Asn Lys Lys Tyr Leu His Leu Asp Leu Leu 
65                  70                  75                  80  


Thr Gly Asn Leu Leu Leu Asn Glu Lys Leu Asp Arg Asp Glu Leu Cys 
                85                  90                  95      


Gly Ser Thr Glu Pro Cys Val Leu His Phe Gln Val Val Leu Glu Asn 
            100                 105                 110         


Pro Leu Gln Phe Phe Arg Phe Glu Leu Cys Val Lys Asp Ile Asn Asp 
        115                 120                 125             


His Ser Pro Thr Phe Leu Asp Lys Glu Ile Leu Ile Lys Ile Ser Glu 
    130                 135                 140                 


Gly Thr Thr Val Gly Ala Thr Phe Leu Met Glu Ser Ala Gln Asp Leu 
145                 150                 155                 160 


Asp Val Gly Ser Asn Ser Leu Gln Asn Tyr Thr Ile Ser Pro Asn Ser 
                165                 170                 175     


His Phe Tyr Ile Lys Ile Pro Asp Ser Ser Asp Arg Lys Ile Tyr Pro 
            180                 185                 190         


Glu Leu Val Leu Asp Arg Ala Leu Asp Tyr Glu Gln Glu Ala Glu Leu 
        195                 200                 205             


Arg Leu Thr Leu Thr Ala Val Asp Gly Gly Ser Pro Pro Lys Ser Gly 
    210                 215                 220                 


Thr Thr Leu Val Leu Ile Lys Val Leu Asp Ile Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Glu Phe Pro Gln Ser Leu Tyr Glu Val Gln Val Pro Glu Asp Arg Pro 
                245                 250                 255     


Leu Gly Ser Trp Ile Ala Thr Ile Ser Ala Lys Asp Leu Asp Ala Gly 
            260                 265                 270         


Asn Tyr Gly Lys Ile Ser Tyr Thr Phe Phe His Ala Ser Glu Asp Ile 
        275                 280                 285             


Arg Lys Thr Phe Glu Ile Asn Pro Ile Ser Gly Glu Val Asn Leu Arg 
    290                 295                 300                 


Ser Pro Leu Asp Phe Glu Val Ile Gln Ser Tyr Thr Ile Asn Ile Gln 
305                 310                 315                 320 


Ala Thr Asp Gly Gly Gly Leu Ser Gly Lys Cys Thr Leu Leu Val Lys 
                325                 330                 335     


Val Met Asp Ile Asn Asp Asn Pro Pro Glu Val Thr Ile Ser Ser Ile 
            340                 345                 350         


Thr Lys Arg Ile Pro Glu Asn Ala Ser Glu Thr Leu Val Ala Leu Phe 
        355                 360                 365             


Ser Ile Leu Asp Gln Asp Ser Gly Asp Asn Gly Arg Met Ile Cys Ser 
    370                 375                 380                 


Ile Gln Asp Asn Leu Pro Phe Phe Leu Lys Pro Thr Phe Lys Asn Phe 
385                 390                 395                 400 


Phe Thr Leu Val Ser Glu Lys Ala Leu Asp Arg Glu Ser Gln Ala Glu 
                405                 410                 415     


Tyr Asn Ile Thr Ile Thr Val Thr Asp Leu Gly Thr Pro Arg Leu Lys 
            420                 425                 430         


Thr Glu Tyr Asn Ile Thr Val Leu Leu Ser Asp Val Asn Asp Asn Ala 
        435                 440                 445             


Pro Thr Phe Thr Gln Thr Ser Tyr Thr Leu Phe Val Arg Glu Asn Asn 
    450                 455                 460                 


Ser Pro Ala Leu His Ile Gly Ser Val Ser Ala Thr Asp Arg Asp Ser 
465                 470                 475                 480 


Gly Thr Asn Ala Gln Val Asn Tyr Ser Leu Leu Pro Pro Gln Asp Arg 
                485                 490                 495     


His Leu Pro Leu Ala Ser Leu Val Ser Ile Asn Ala Asp Asn Gly His 
            500                 505                 510         


Leu Phe Ala Leu Arg Ser Leu Asp Tyr Glu Ala Leu Gln Glu Phe Glu 
        515                 520                 525             


Phe Arg Val Gly Ala Thr Asp Arg Gly Ser Pro Ala Leu Ser Ser Glu 
    530                 535                 540                 


Ala Leu Val Arg Val Leu Val Leu Asp Ala Asn Asp Asn Ser Pro Phe 
545                 550                 555                 560 


Val Leu Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu Leu Val 
                565                 570                 575     


Pro Arg Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val 
            580                 585                 590         


Asp Gly Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu Lys 
        595                 600                 605             


Ala Thr Glu Pro Gly Leu Phe Gly Val Trp Ala His Asn Gly Glu Val 
    610                 615                 620                 


Arg Thr Ala Arg Leu Leu Ser Glu Arg Asp Ala Ala Lys His Arg Leu 
625                 630                 635                 640 


Val Val Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr Ala 
                645                 650                 655     


Thr Leu His Val Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr Leu Pro 
            660                 665                 670         


Leu Pro Glu Ala Ala Pro Ala Gln Ala Gln Ala Asp Ser Leu Thr Val 
        675                 680                 685             


Tyr Leu Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu Phe Ser 
    690                 695                 700                 


Val Leu Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg Ala Ala 
705                 710                 715                 720 


Ser Val Gly Arg Cys Ser Val Pro Glu Gly Pro Phe Pro Gly His Leu 
                725                 730                 735     


Val Asp Val Ser Gly Thr Gly Thr Leu Ser Gln Ser Tyr Gln Tyr Glu 
            740                 745                 750         


Val Cys Leu Thr Gly Gly Ser Gly Thr Asn Glu Phe Lys Phe Leu Lys 
        755                 760                 765             


Pro Ile Ile Pro Asn Phe Gln Val His Asp Thr Gly Arg Asn Met Gly 
    770                 775                 780                 


Glu Ile Glu Asn Phe Arg Asn Ser Phe Gly Leu Asn Ile Gln 
785                 790                 795             


<210>  4530
<211>  794
<212>  PRT
<213>  Homo sapiens

<400>  4530

Met Met Gln Thr Lys Val Gln Asn Lys Lys Arg Gln Val Ala Phe Phe 
1               5                   10                  15      


Ile Leu Leu Met Leu Trp Gly Glu Val Gly Ser Glu Ser Ile Gln Tyr 
            20                  25                  30          


Ser Val Leu Glu Glu Thr Glu Ser Gly Thr Phe Val Ala Asn Leu Thr 
        35                  40                  45              


Lys Asp Leu Gly Leu Arg Val Gly Glu Leu Ala Ser Arg Gly Ala Arg 
    50                  55                  60                  


Val Val Phe Lys Gly Asn Arg Gln His Leu Gln Phe Asp Pro Gln Thr 
65                  70                  75                  80  


His Asp Leu Leu Leu Asn Glu Lys Leu Asp Arg Glu Glu Leu Cys Gly 
                85                  90                  95      


Ser Thr Glu Pro Cys Val Leu Pro Phe Gln Val Leu Leu Glu Asn Pro 
            100                 105                 110         


Leu Gln Phe Phe Gln Ala Ser Leu Arg Val Arg Asp Ile Asn Asp His 
        115                 120                 125             


Ala Pro Glu Phe Pro Ala Arg Glu Met Leu Leu Lys Ile Ser Glu Ile 
    130                 135                 140                 


Thr Met Pro Gly Lys Ile Phe Pro Leu Lys Met Ala His Asp Leu Asp 
145                 150                 155                 160 


Thr Gly Ser Asn Gly Leu Gln Arg Tyr Thr Ile Ser Ser Asn Pro His 
                165                 170                 175     


Phe His Val Leu Thr Arg Asn Arg Ser Glu Gly Arg Lys Phe Pro Glu 
            180                 185                 190         


Leu Val Leu Asp Lys Pro Leu Asp Arg Glu Glu Gln Pro Gln Leu Arg 
        195                 200                 205             


Leu Thr Leu Ile Ala Leu Asp Gly Gly Ser Pro Pro Arg Ser Gly Thr 
    210                 215                 220                 


Ser Glu Ile Gln Ile Gln Val Leu Asp Ile Asn Asp Asn Val Pro Glu 
225                 230                 235                 240 


Phe Ala Gln Glu Leu Tyr Glu Ala Gln Val Pro Glu Asn Asn Pro Leu 
                245                 250                 255     


Gly Ser Leu Val Ile Thr Val Ser Ala Arg Asp Leu Asp Ala Gly Ser 
            260                 265                 270         


Phe Gly Lys Val Ser Tyr Ala Leu Phe Gln Val Asp Asp Val Asn Gln 
        275                 280                 285             


Pro Phe Glu Ile Asn Ala Ile Thr Gly Glu Ile Arg Leu Arg Lys Ala 
    290                 295                 300                 


Leu Asp Phe Glu Glu Ile Gln Ser Tyr Asp Val Asp Val Glu Ala Thr 
305                 310                 315                 320 


Asp Gly Gly Gly Leu Ser Gly Lys Cys Ser Leu Val Val Arg Val Leu 
                325                 330                 335     


Asp Val Asn Asp Asn Ala Pro Glu Leu Thr Met Ser Phe Phe Ile Ser 
            340                 345                 350         


Leu Ile Pro Glu Asn Leu Pro Glu Ile Thr Val Ala Val Phe Ser Val 
        355                 360                 365             


Ser Asp Ala Asp Ser Gly His Asn Gln Gln Val Ile Cys Ser Ile Glu 
    370                 375                 380                 


Asn Asn Leu Pro Phe Leu Leu Arg Pro Ser Val Glu Asn Phe Tyr Thr 
385                 390                 395                 400 


Leu Val Thr Glu Gly Ala Leu Asp Arg Glu Ser Arg Ala Glu Tyr Asn 
                405                 410                 415     


Ile Thr Ile Thr Val Thr Asp Leu Gly Thr Pro Arg Leu Lys Thr Gln 
            420                 425                 430         


Gln Ser Ile Thr Val Gln Val Ser Asp Val Asn Asp Asn Ala Pro Ala 
        435                 440                 445             


Phe Thr Gln Thr Ser Tyr Thr Leu Phe Val Arg Glu Asn Asn Ser Pro 
    450                 455                 460                 


Ala Leu His Ile Gly Ser Val Ser Ala Thr Asp Arg Asp Ser Gly Ile 
465                 470                 475                 480 


Asn Ala Gln Val Thr Tyr Ser Leu Leu Pro Pro Gln Asp Pro His Leu 
                485                 490                 495     


Pro Leu Ser Ser Leu Val Ser Ile Asn Ala Asp Asn Gly His Leu Phe 
            500                 505                 510         


Ala Leu Arg Ser Leu Asp Tyr Glu Ala Leu Gln Ser Phe Glu Phe Arg 
        515                 520                 525             


Val Gly Ala Thr Asp Arg Gly Ser Pro Ala Leu Ser Ser Glu Ala Leu 
    530                 535                 540                 


Val Arg Leu Leu Val Leu Asp Ala Asn Asp Asn Ser Pro Phe Val Leu 
545                 550                 555                 560 


Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu Leu Val Pro Arg 
                565                 570                 575     


Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val Asp Gly 
            580                 585                 590         


Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu Lys Ala Thr 
        595                 600                 605             


Glu Leu Gly Leu Phe Gly Val Trp Ala His Asn Gly Glu Val Arg Thr 
    610                 615                 620                 


Ala Arg Leu Leu Ser Glu Arg Asp Ala Ala Lys His Arg Leu Val Val 
625                 630                 635                 640 


Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr Ala Thr Leu 
                645                 650                 655     


His Val Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr Leu Pro Leu Pro 
            660                 665                 670         


Glu Ala Ala Pro Ala Gln Ala Gln Ala Asp Ser Leu Thr Val Tyr Leu 
        675                 680                 685             


Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu Phe Ser Val Leu 
    690                 695                 700                 


Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg Ala Ala Ser Val 
705                 710                 715                 720 


Gly Arg Tyr Ser Val Pro Glu Gly Pro Phe Pro Gly His Leu Val Asp 
                725                 730                 735     


Val Ser Gly Thr Gly Thr Leu Ser Gln Ser Tyr Gln Tyr Lys Val Cys 
            740                 745                 750         


Leu Thr Gly Gly Ser Glu Thr Asn Glu Phe Lys Phe Leu Lys Pro Ile 
        755                 760                 765             


Met Pro Asn Phe Pro Pro Gln Gly Thr Glu Arg Glu Met Glu Glu Thr 
    770                 775                 780                 


Pro Thr Ser Arg Asn Ser Phe Pro Phe Ser 
785                 790                 


<210>  4531
<211>  793
<212>  PRT
<213>  Homo sapiens

<400>  4531

Met Glu Ala Arg Val Glu Arg Ala Val Gln Lys Arg Gln Val Leu Phe 
1               5                   10                  15      


Leu Cys Val Phe Leu Gly Met Ser Trp Ala Gly Ala Glu Pro Leu Arg 
            20                  25                  30          


Tyr Phe Val Ala Glu Glu Thr Glu Arg Gly Thr Phe Leu Thr Asn Leu 
        35                  40                  45              


Ala Lys Asp Leu Gly Leu Gly Val Gly Glu Leu Arg Ala Arg Gly Thr 
    50                  55                  60                  


Arg Ile Val Ser Asp Gln Asn Met Gln Ile Leu Leu Leu Ser Ser Leu 
65                  70                  75                  80  


Thr Gly Asp Leu Leu Leu Asn Glu Lys Leu Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Pro Arg Glu Pro Cys Val Leu Pro Phe Gln Leu Leu Leu Glu Lys 
            100                 105                 110         


Pro Phe Gln Ile Phe Arg Ala Glu Leu Trp Val Arg Asp Ile Asn Asp 
        115                 120                 125             


His Ala Pro Val Phe Leu Asp Arg Glu Ile Ser Leu Lys Ile Leu Glu 
    130                 135                 140                 


Ser Thr Thr Pro Gly Ala Ala Phe Leu Leu Glu Ser Ala Gln Asp Ser 
145                 150                 155                 160 


Asp Val Gly Thr Asn Ser Leu Ser Asn Tyr Thr Ile Ser Pro Asn Ala 
                165                 170                 175     


Tyr Phe His Ile Asn Val His Asp Ser Gly Glu Gly Asn Ile Tyr Pro 
            180                 185                 190         


Glu Leu Val Leu Asn Gln Val Leu Asp Arg Glu Glu Ile Pro Glu Phe 
        195                 200                 205             


Ser Leu Thr Leu Thr Ala Leu Asp Gly Gly Ser Pro Pro Arg Ser Gly 
    210                 215                 220                 


Thr Ala Leu Val Arg Ile Leu Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Asp Phe Val Arg Ser Leu Tyr Lys Val Gln Val Pro Glu Asn Ser Pro 
                245                 250                 255     


Val Gly Ser Met Val Val Ser Val Ser Ala Arg Asp Leu Asp Thr Gly 
            260                 265                 270         


Ser Asn Gly Glu Ile Ala Tyr Ala Phe Ser Tyr Ala Thr Glu Arg Ile 
        275                 280                 285             


Leu Lys Thr Phe Gln Ile Asn Pro Thr Ser Gly Ser Leu His Leu Lys 
    290                 295                 300                 


Ala Gln Leu Asp Tyr Glu Ala Ile Gln Thr Tyr Thr Leu Thr Ile Gln 
305                 310                 315                 320 


Ala Lys Asp Gly Gly Gly Leu Ser Gly Lys Cys Thr Val Val Val Asp 
                325                 330                 335     


Val Thr Asp Ile Asn Asp Asn Arg Pro Glu Leu Leu Leu Ser Ser Leu 
            340                 345                 350         


Thr Ser Pro Ile Ala Glu Asn Ser Pro Glu Thr Val Val Ala Val Phe 
        355                 360                 365             


Arg Ile Arg Asp Arg Asp Ser Gly Asn Asn Gly Lys Thr Val Cys Ser 
    370                 375                 380                 


Ile Gln Asp Asp Val Pro Phe Ile Leu Lys Pro Ser Val Glu Asn Phe 
385                 390                 395                 400 


Tyr Thr Leu Val Thr Glu Lys Pro Leu Asp Arg Glu Arg Asn Thr Glu 
                405                 410                 415     


Tyr Asn Ile Thr Ile Thr Val Thr Asp Leu Gly Thr Pro Arg Leu Lys 
            420                 425                 430         


Thr Glu His Asn Ile Thr Val Leu Val Ser Asp Val Asn Asp Asn Ala 
        435                 440                 445             


Pro Ala Phe Thr Gln Thr Ser Tyr Thr Leu Phe Val Arg Glu Asn Asn 
    450                 455                 460                 


Ser Pro Ala Leu Pro Ile Gly Ser Val Ser Ala Thr Asp Arg Asp Ser 
465                 470                 475                 480 


Gly Thr Asn Ala Gln Val Ile Tyr Ser Leu Leu Pro Ser Gln Asp Pro 
                485                 490                 495     


His Leu Pro Leu Ala Ser Leu Val Ser Ile Asn Ala Asp Asn Gly His 
            500                 505                 510         


Leu Phe Ala Leu Arg Ser Leu Asp Tyr Glu Ala Leu Gln Ala Phe Glu 
        515                 520                 525             


Phe Arg Val Gly Ala Thr Asp Arg Gly Ser Pro Ala Leu Ser Ser Glu 
    530                 535                 540                 


Ala Leu Val Arg Val Leu Val Leu Asp Ala Asn Asp Asn Ser Pro Phe 
545                 550                 555                 560 


Val Leu Tyr Pro Leu Gln Asn Ser Ser Ala Pro Cys Thr Glu Pro Leu 
                565                 570                 575     


Pro Arg Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val 
            580                 585                 590         


Asp Gly Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu Lys 
        595                 600                 605             


Ala Thr Glu Pro Gly Leu Phe Gly Val Trp Ala His Asn Gly Glu Val 
    610                 615                 620                 


Arg Thr Ala Arg Leu Leu Ser Glu Arg Asp Ala Ala Lys Gln Arg Leu 
625                 630                 635                 640 


Val Val Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr Ala 
                645                 650                 655     


Thr Leu His Val Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr Leu Arg 
            660                 665                 670         


Leu Pro Glu Ala Ala Pro Asp Gln Ala Asn Ser Leu Thr Val Tyr Leu 
        675                 680                 685             


Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu Leu Ser Val Leu 
    690                 695                 700                 


Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg Ala Ala Pro Val 
705                 710                 715                 720 


Gly Arg Cys Ser Val Pro Glu Gly Pro Phe Pro Arg His Leu Val Asp 
                725                 730                 735     


Leu Ser Gly Thr Gly Thr Leu Ser Gln Ser Tyr Gln Tyr Glu Val Cys 
            740                 745                 750         


Leu Thr Gly Gly Ser Gly Thr Asn Glu Phe Lys Phe Leu Lys Pro Ile 
        755                 760                 765             


Ile Pro Asn Leu Leu Pro Gln Ser Thr Gly Arg Glu Val Glu Glu Asn 
    770                 775                 780                 


Arg Pro Phe Gln Asn Asn Leu Gly Phe 
785                 790             


<210>  4532
<211>  286
<212>  PRT
<213>  Homo sapiens

<400>  4532

Met Asn Pro Ala Ser Asp Gly Gly Thr Ser Glu Ser Ile Phe Asp Leu 
1               5                   10                  15      


Asp Tyr Ala Ser Trp Gly Ile Arg Ser Thr Leu Met Val Ala Gly Phe 
            20                  25                  30          


Val Phe Tyr Leu Gly Val Phe Val Val Cys His Gln Leu Ser Ser Ser 
        35                  40                  45              


Leu Asn Ala Thr Tyr Arg Ser Leu Val Ala Arg Glu Lys Val Phe Trp 
    50                  55                  60                  


Asp Leu Ala Ala Thr Arg Ala Val Phe Gly Val Gln Ser Thr Ala Ala 
65                  70                  75                  80  


Gly Leu Trp Ala Leu Leu Gly Asp Pro Val Leu His Ala Asp Lys Ala 
                85                  90                  95      


Arg Gly Gln Gln Asn Trp Cys Trp Phe His Ile Thr Thr Ala Thr Gly 
            100                 105                 110         


Phe Phe Cys Phe Glu Asn Val Ala Val His Leu Ser Asn Leu Ile Phe 
        115                 120                 125             


Arg Thr Phe Asp Leu Phe Leu Val Ile His His Leu Phe Ala Phe Leu 
    130                 135                 140                 


Gly Phe Leu Gly Cys Leu Val Asn Leu Gln Ala Gly His Tyr Leu Ala 
145                 150                 155                 160 


Met Thr Thr Leu Leu Leu Glu Met Ser Thr Pro Phe Thr Cys Val Ser 
                165                 170                 175     


Trp Met Leu Leu Lys Ala Gly Trp Ser Glu Ser Leu Phe Trp Lys Leu 
            180                 185                 190         


Asn Gln Trp Leu Met Ile His Met Phe His Cys Arg Met Val Leu Thr 
        195                 200                 205             


Tyr His Met Trp Trp Val Cys Phe Trp His Trp Asp Gly Leu Val Ser 
    210                 215                 220                 


Ser Leu Tyr Leu Pro His Leu Thr Leu Phe Leu Val Gly Leu Ala Leu 
225                 230                 235                 240 


Leu Thr Leu Ile Ile Asn Pro Tyr Trp Thr His Lys Lys Thr Gln Gln 
                245                 250                 255     


Leu Leu Asn Pro Val Asp Trp Asn Phe Ala Gln Pro Glu Ala Lys Ser 
            260                 265                 270         


Arg Pro Glu Gly Asn Gly Gln Leu Leu Arg Lys Lys Arg Pro 
        275                 280                 285     


<210>  4533
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  4533

Met Arg Glu Cys Ile Ser Val His Val Gly Gln Ala Gly Val Gln Ile 
1               5                   10                  15      


Gly Asn Ala Cys Trp Glu Leu Phe Cys Leu Glu His Gly Ile Gln Ala 
            20                  25                  30          


Asp Gly Thr Phe Asp Ala Gln Ala Ser Lys Ile Asn Asp Asp Asp Ser 
        35                  40                  45              


Phe Thr Thr Phe Phe Ser Glu Thr Gly Asn Gly Lys His Val Pro Arg 
    50                  55                  60                  


Ala Val Met Ile Asp Leu Glu Pro Thr Val Val Asp Glu Val Arg Ala 
65                  70                  75                  80  


Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys 
                85                  90                  95      


Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Val Gly Lys 
            100                 105                 110         


Glu Ser Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Thr Asp Ala 
        115                 120                 125             


Cys Ser Gly Leu Gln Gly Phe Leu Ile Phe His Ser Phe Gly Gly Gly 
    130                 135                 140                 


Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Leu Asp 
145                 150                 155                 160 


Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ala Ile Tyr Pro Ala Pro Gln 
                165                 170                 175     


Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His 
            180                 185                 190         


Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala 
        195                 200                 205             


Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr 
    210                 215                 220                 


Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala 
225                 230                 235                 240 


Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln 
                245                 250                 255     


Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Val Thr Tyr 
            260                 265                 270         


Ala Pro Ile Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val 
        275                 280                 285             


Ala Glu Ile Thr Ser Ser Cys Phe Glu Pro Asn Ser Gln Met Val Lys 
    290                 295                 300                 


Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Met Leu Tyr Arg 
305                 310                 315                 320 


Gly Asp Val Val Pro Lys Asp Val Asn Val Ala Ile Ala Ala Ile Lys 
                325                 330                 335     


Thr Lys Arg Thr Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys 
            340                 345                 350         


Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu 
        355                 360                 365             


Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile 
    370                 375                 380                 


Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala 
385                 390                 395                 400 


Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly 
                405                 410                 415     


Glu Phe Ser Glu Ala Arg Glu Asp Leu Ala Ala Leu Glu Lys Asp Tyr 
            420                 425                 430         


Glu Glu Val Gly Thr Asp Ser Phe Glu Glu Glu Asn Glu Gly Glu Glu 
        435                 440                 445             


Phe 
    


<210>  4534
<211>  389
<212>  PRT
<213>  Homo sapiens

<400>  4534

Met Ala Leu Thr Pro Glu Ser Pro Ser Ser Phe Pro Gly Leu Ala Ala 
1               5                   10                  15      


Thr Gly Ser Ser Val Pro Glu Pro Pro Gly Gly Pro Asn Ala Thr Leu 
            20                  25                  30          


Asn Ser Ser Trp Ala Ser Pro Thr Glu Pro Ser Ser Leu Glu Asp Leu 
        35                  40                  45              


Val Ala Thr Gly Thr Ile Gly Thr Leu Leu Ser Ala Met Gly Val Val 
    50                  55                  60                  


Gly Val Val Gly Asn Ala Tyr Thr Leu Val Val Thr Cys Arg Ser Leu 
65                  70                  75                  80  


Arg Ala Val Ala Ser Met Tyr Val Tyr Val Val Asn Leu Ala Leu Ala 
                85                  90                  95      


Asp Leu Leu Tyr Leu Leu Ser Ile Pro Phe Ile Val Ala Thr Tyr Val 
            100                 105                 110         


Thr Lys Glu Trp His Phe Gly Asp Val Gly Cys Arg Val Leu Phe Gly 
        115                 120                 125             


Leu Asp Phe Leu Thr Met His Ala Ser Ile Phe Thr Leu Thr Val Met 
    130                 135                 140                 


Ser Ser Glu Arg Tyr Ala Ala Val Leu Arg Pro Leu Asp Thr Val Gln 
145                 150                 155                 160 


Arg Pro Lys Gly Tyr Arg Lys Leu Leu Ala Leu Gly Thr Trp Leu Leu 
                165                 170                 175     


Ala Leu Leu Leu Thr Leu Pro Val Met Leu Ala Met Arg Leu Val Arg 
            180                 185                 190         


Arg Gly Pro Lys Ser Leu Cys Leu Pro Ala Trp Gly Pro Arg Ala His 
        195                 200                 205             


Arg Ala Tyr Leu Thr Leu Leu Phe Ala Thr Ser Ile Ala Gly Pro Gly 
    210                 215                 220                 


Leu Leu Ile Gly Leu Leu Tyr Ala Arg Leu Ala Arg Ala Tyr Arg Arg 
225                 230                 235                 240 


Ser Gln Arg Ala Ser Phe Lys Arg Ala Arg Arg Pro Gly Ala Arg Ala 
                245                 250                 255     


Leu Arg Leu Val Leu Gly Ile Val Leu Leu Phe Trp Ala Cys Phe Leu 
            260                 265                 270         


Pro Phe Trp Leu Trp Gln Leu Leu Ala Gln Tyr His Gln Ala Pro Leu 
        275                 280                 285             


Ala Pro Arg Thr Ala Arg Ile Val Asn Tyr Leu Thr Thr Cys Leu Thr 
    290                 295                 300                 


Tyr Gly Asn Ser Cys Ala Asn Pro Phe Leu Tyr Thr Leu Leu Thr Arg 
305                 310                 315                 320 


Asn Tyr Arg Asp His Leu Arg Gly Arg Val Arg Gly Pro Gly Ser Gly 
                325                 330                 335     


Gly Gly Arg Gly Pro Val Pro Ser Leu Gln Pro Arg Ala Arg Phe Gln 
            340                 345                 350         


Arg Cys Ser Gly Arg Ser Leu Ser Ser Cys Ser Pro Gln Pro Thr Asp 
        355                 360                 365             


Ser Leu Val Leu Ala Pro Ala Ala Pro Ala Arg Pro Ala Pro Glu Gly 
    370                 375                 380                 


Pro Arg Ala Pro Ala 
385                 


<210>  4535
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  4535

Met Ala Pro Arg Ser Leu Leu Leu Leu Leu Ser Gly Ala Leu Ala Leu 
1               5                   10                  15      


Thr Asp Thr Trp Ala Gly Ser His Ser Leu Arg Tyr Phe Ser Thr Ala 
            20                  25                  30          


Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Tyr Ile Ala Val Glu Tyr 
        35                  40                  45              


Val Asp Asp Thr Gln Phe Leu Arg Phe Asp Ser Asp Ala Ala Ile Pro 
    50                  55                  60                  


Arg Met Glu Pro Arg Glu Pro Trp Val Glu Gln Glu Gly Pro Gln Tyr 
65                  70                  75                  80  


Trp Glu Trp Thr Thr Gly Tyr Ala Lys Ala Asn Ala Gln Thr Asp Arg 
                85                  90                  95      


Val Ala Leu Arg Asn Leu Leu Arg Arg Tyr Asn Gln Ser Glu Ala Gly 
            100                 105                 110         


Ser His Thr Leu Gln Gly Met Asn Gly Cys Asp Met Gly Pro Asp Gly 
        115                 120                 125             


Arg Leu Leu Arg Gly Tyr His Gln His Ala Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Ile Ser Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Val 
145                 150                 155                 160 


Ala Gln Ile Thr Gln Arg Phe Tyr Glu Ala Glu Glu Tyr Ala Glu Glu 
                165                 170                 175     


Phe Arg Thr Tyr Leu Glu Gly Glu Cys Leu Glu Leu Leu Arg Arg Tyr 
            180                 185                 190         


Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro Pro Lys Ala 
        195                 200                 205             


His Val Ala His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys 
    210                 215                 220                 


Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg 
225                 230                 235                 240 


Asp Gly Glu Glu Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro 
                245                 250                 255     


Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Pro 
            260                 265                 270         


Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro 
        275                 280                 285             


Gln Pro Leu Ile Leu Arg Trp Glu Gln Ser Pro Gln Pro Thr Ile Pro 
    290                 295                 300                 


Ile Val Gly Ile Val Ala Gly Leu Val Val Leu Gly Ala Val Val Thr 
305                 310                 315                 320 


Gly Ala Val Val Ala Ala Val Met Trp Arg Lys Lys Ser Ser Asp Arg 
                325                 330                 335     


Asn Arg Gly Ser Tyr Ser Gln Ala Ala Val 
            340                 345     


<210>  4536
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  4536

Met Ala Arg Leu Pro Ala Gly Ile Arg Phe Ile Ile Ser Phe Ser Arg 
1               5                   10                  15      


Asp Gln Trp Tyr Arg Ala Phe Ile Phe Ile Leu Thr Phe Leu Leu Tyr 
            20                  25                  30          


Ala Ser Phe His Leu Ser Arg Lys Pro Ile Ser Ile Val Lys Gly Glu 
        35                  40                  45              


Leu His Lys Tyr Cys Thr Ala Trp Asp Glu Ala Asp Val Arg Phe Ser 
    50                  55                  60                  


Ser Gln Asn Arg Lys Ser Gly Ser Ala Ala Pro His Gln Leu Pro Asp 
65                  70                  75                  80  


Asn Glu Thr Asp Cys Gly Trp Ala Pro Phe Asp Lys Asn Asn Tyr Gln 
                85                  90                  95      


Gln Leu Leu Gly Ala Leu Asp Tyr Ser Phe Leu Cys Ala Tyr Ala Val 
            100                 105                 110         


Gly Met Tyr Leu Ser Gly Ile Ile Gly Glu Arg Leu Pro Ile Arg Tyr 
        115                 120                 125             


Tyr Leu Thr Phe Gly Met Leu Ala Ser Gly Ala Phe Thr Ala Leu Phe 
    130                 135                 140                 


Gly Leu Gly Tyr Phe Tyr Asn Ile His Ser Phe Gly Phe Tyr Val Val 
145                 150                 155                 160 


Thr Gln Val Ile Asn Gly Leu Val Gln Thr Thr Gly Trp Pro Ser Val 
                165                 170                 175     


Val Thr Cys Leu Gly Asn Trp Phe Gly Lys Gly Arg Arg Gly Leu Ile 
            180                 185                 190         


Met Gly Val Trp Asn Ser His Thr Ser Val Gly Asn Ile Leu Gly Ser 
        195                 200                 205             


Leu Ile Ala Gly Tyr Trp Val Ser Thr Cys Trp Gly Leu Ser Phe Val 
    210                 215                 220                 


Val Pro Gly Ala Ile Val Ala Ala Met Gly Ile Val Cys Phe Leu Phe 
225                 230                 235                 240 


Leu Ile Glu His Pro Asn Asp Val Arg Cys Ser Ser Thr Leu Val Thr 
                245                 250                 255     


His Ser Lys Gly Tyr Glu Asn Gly Thr Asn Arg Leu Arg Leu Gln Lys 
            260                 265                 270         


Gln Ile Leu Lys Ser Glu Lys Asn Lys Pro Leu Asp Pro Glu Met Gln 
        275                 280                 285             


Cys Leu Leu Leu Ser Asp Gly Lys Gly Ser Ile His Pro Asn His Val 
    290                 295                 300                 


Val Ile Leu Pro Gly Asp Gly Gly Ser Gly Thr Ala Ala Ile Ser Phe 
305                 310                 315                 320 


Thr Gly Ala Leu Lys Ile Pro Gly Val Ile Glu Phe Ser Leu Cys Leu 
                325                 330                 335     


Leu Phe Ala Lys Leu Val Ser Tyr Thr Phe Leu Phe Trp Leu Pro Leu 
            340                 345                 350         


Tyr Ile Thr Asn Val Asp His Leu Asp Ala Lys Lys Ala Gly Glu Leu 
        355                 360                 365             


Ser Thr Leu Phe Asp Val Gly Gly Ile Phe Gly Gly Ile Leu Ala Gly 
    370                 375                 380                 


Val Ile Ser Asp Arg Leu Glu Lys Arg Ala Ser Thr Cys Gly Leu Met 
385                 390                 395                 400 


Leu Leu Leu Ala Ala Pro Thr Leu Tyr Ile Phe Ser Thr Val Ser Lys 
                405                 410                 415     


Met Gly Leu Glu Ala Thr Ile Ala Met Leu Leu Leu Ser Gly Ala Leu 
            420                 425                 430         


Val Ser Gly Pro Tyr Thr Leu Ile Thr Thr Ala Val Ser Ala Asp Leu 
        435                 440                 445             


Gly Thr His Lys Ser Leu Lys Gly Asn Ala His Ala Leu Ser Thr Val 
    450                 455                 460                 


Thr Ala Ile Ile Asp Gly Thr Gly Ser Val Gly Ala Ala Leu Gly Pro 
465                 470                 475                 480 


Leu Leu Ala Gly Leu Leu Ser Pro Ser Gly Trp Ser Asn Val Phe Tyr 
                485                 490                 495     


Met Leu Met Phe Ala Asp Ala Cys Ala Leu Leu Phe Leu Ile Arg Leu 
            500                 505                 510         


Ile His Lys Glu Leu Ser Cys Pro Gly Ser Ala Thr Gly Asp Gln Val 
        515                 520                 525             


Pro Phe Lys Glu Gln 
    530             


<210>  4537
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  4537

Met Glu Pro Leu Arg Leu Leu Ile Leu Leu Phe Val Thr Glu Leu Ser 
1               5                   10                  15      


Gly Ala His Asn Thr Thr Val Phe Gln Gly Val Ala Gly Gln Ser Leu 
            20                  25                  30          


Gln Val Ser Cys Pro Tyr Asp Ser Met Lys His Trp Gly Arg Arg Lys 
        35                  40                  45              


Ala Trp Cys Arg Gln Leu Gly Glu Lys Gly Pro Cys Gln Arg Val Val 
    50                  55                  60                  


Ser Thr His Asn Leu Trp Leu Leu Ser Phe Leu Arg Arg Trp Asn Gly 
65                  70                  75                  80  


Ser Thr Ala Ile Thr Asp Asp Thr Leu Gly Gly Thr Leu Thr Ile Thr 
                85                  90                  95      


Leu Arg Asn Leu Gln Pro His Asp Ala Gly Leu Tyr Gln Cys Gln Ser 
            100                 105                 110         


Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu Val 
        115                 120                 125             


Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe Pro 
    130                 135                 140                 


Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu His Ser Ile Ser 
145                 150                 155                 160 


Arg Ser Leu Leu Glu Gly Glu Ile Pro Phe Pro Pro Thr Ser Ile Leu 
                165                 170                 175     


Leu Leu Leu Ala Cys Ile Phe Leu Ile Lys Ile Leu Ala Ala Ser Ala 
            180                 185                 190         


Leu Trp Ala Ala Ala Trp His Gly Gln Lys Pro Gly Thr His Pro Pro 
        195                 200                 205             


Ser Glu Leu Asp Cys Gly His Asp Pro Gly Tyr Gln Leu Gln Thr Leu 
    210                 215                 220                 


Pro Gly Leu Arg Asp Thr 
225                 230 


<210>  4538
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  4538

Met Ala Asn Thr Thr Gly Glu Pro Glu Glu Val Ser Gly Ala Leu Ser 
1               5                   10                  15      


Pro Pro Ser Ala Ser Ala Tyr Val Lys Leu Val Leu Leu Gly Leu Ile 
            20                  25                  30          


Met Cys Val Ser Leu Ala Gly Asn Ala Ile Leu Ser Leu Leu Val Leu 
        35                  40                  45              


Lys Glu Arg Ala Leu His Lys Ala Pro Tyr Tyr Phe Leu Leu Asp Leu 
    50                  55                  60                  


Cys Leu Ala Asp Gly Ile Arg Ser Ala Val Cys Phe Pro Phe Val Leu 
65                  70                  75                  80  


Ala Ser Val Arg His Gly Ser Ser Trp Thr Phe Ser Ala Leu Ser Cys 
                85                  90                  95      


Lys Ile Val Ala Phe Met Ala Val Leu Phe Cys Phe His Ala Ala Phe 
            100                 105                 110         


Met Leu Phe Cys Ile Ser Val Thr Arg Tyr Met Ala Ile Ala His His 
        115                 120                 125             


Arg Phe Tyr Ala Lys Arg Met Thr Leu Trp Thr Cys Ala Ala Val Ile 
    130                 135                 140                 


Cys Met Ala Trp Thr Leu Ser Val Ala Met Ala Phe Pro Pro Val Phe 
145                 150                 155                 160 


Asp Val Gly Thr Tyr Lys Phe Ile Arg Glu Glu Asp Gln Cys Ile Phe 
                165                 170                 175     


Glu His Arg Tyr Phe Lys Ala Asn Asp Thr Leu Gly Phe Met Leu Met 
            180                 185                 190         


Leu Ala Val Leu Met Ala Ala Thr His Ala Val Tyr Gly Lys Leu Leu 
        195                 200                 205             


Leu Phe Glu Tyr Arg His Arg Lys Met Lys Pro Val Gln Met Val Pro 
    210                 215                 220                 


Ala Ile Ser Gln Asn Trp Thr Phe His Gly Pro Gly Ala Thr Gly Gln 
225                 230                 235                 240 


Ala Ala Ala Asn Trp Ile Ala Gly Phe Gly Arg Gly Pro Met Pro Pro 
                245                 250                 255     


Thr Leu Leu Gly Ile Arg Gln Asn Gly His Ala Ala Ser Arg Arg Leu 
            260                 265                 270         


Leu Gly Met Asp Glu Val Lys Gly Glu Lys Gln Leu Gly Arg Met Phe 
        275                 280                 285             


Tyr Ala Ile Thr Leu Leu Phe Leu Leu Leu Trp Ser Pro Tyr Ile Val 
    290                 295                 300                 


Ala Cys Tyr Trp Arg Val Phe Val Lys Ala Cys Ala Val Pro His Arg 
305                 310                 315                 320 


Tyr Leu Ala Thr Ala Val Trp Met Ser Phe Ala Gln Ala Ala Val Asn 
                325                 330                 335     


Pro Ile Val Cys Phe Leu Leu Asn Lys Asp Leu Lys Lys Cys Leu Arg 
            340                 345                 350         


Thr His Ala Pro Cys Trp Gly Thr Gly Gly Ala Pro Ala Pro Arg Glu 
        355                 360                 365             


Pro Tyr Cys Val Met 
    370             


<210>  4539
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  4539

Met Ala Asn Tyr Ser His Ala Ala Asp Asn Ile Leu Gln Asn Leu Ser 
1               5                   10                  15      


Pro Leu Thr Ala Phe Leu Lys Leu Thr Ser Leu Gly Phe Ile Ile Gly 
            20                  25                  30          


Val Ser Val Val Gly Asn Leu Leu Ile Ser Ile Leu Leu Val Lys Asp 
        35                  40                  45              


Lys Thr Leu His Arg Ala Pro Tyr Tyr Phe Leu Leu Asp Leu Cys Cys 
    50                  55                  60                  


Ser Asp Ile Leu Arg Ser Ala Ile Cys Phe Pro Phe Val Phe Asn Ser 
65                  70                  75                  80  


Val Lys Asn Gly Ser Thr Trp Thr Tyr Gly Thr Leu Thr Cys Lys Val 
                85                  90                  95      


Ile Ala Phe Leu Gly Val Leu Ser Cys Phe His Thr Ala Phe Met Leu 
            100                 105                 110         


Phe Cys Ile Ser Val Thr Arg Tyr Leu Ala Ile Ala His His Arg Phe 
        115                 120                 125             


Tyr Thr Lys Arg Leu Thr Phe Trp Thr Cys Leu Ala Val Ile Cys Met 
    130                 135                 140                 


Val Trp Thr Leu Ser Val Ala Met Ala Phe Pro Pro Val Leu Asp Val 
145                 150                 155                 160 


Gly Thr Tyr Ser Phe Ile Arg Glu Glu Asp Gln Cys Thr Phe Gln His 
                165                 170                 175     


Arg Ser Phe Arg Ala Asn Asp Ser Leu Gly Phe Met Leu Leu Leu Ala 
            180                 185                 190         


Leu Ile Leu Leu Ala Thr Gln Leu Val Tyr Leu Lys Leu Ile Phe Phe 
        195                 200                 205             


Val His Asp Arg Arg Lys Met Lys Pro Val Gln Phe Val Ala Ala Val 
    210                 215                 220                 


Ser Gln Asn Trp Thr Phe His Gly Pro Gly Ala Ser Gly Gln Ala Ala 
225                 230                 235                 240 


Ala Asn Trp Leu Ala Gly Phe Gly Arg Gly Pro Thr Pro Pro Thr Leu 
                245                 250                 255     


Leu Gly Ile Arg Gln Asn Ala Asn Thr Thr Gly Arg Arg Arg Leu Leu 
            260                 265                 270         


Val Leu Asp Glu Phe Lys Met Glu Lys Arg Ile Ser Arg Met Phe Tyr 
        275                 280                 285             


Ile Met Thr Phe Leu Phe Leu Thr Leu Trp Gly Pro Tyr Leu Val Ala 
    290                 295                 300                 


Cys Tyr Trp Arg Val Phe Ala Arg Gly Pro Val Val Pro Gly Gly Phe 
305                 310                 315                 320 


Leu Thr Ala Ala Val Trp Met Ser Phe Ala Gln Ala Gly Ile Asn Pro 
                325                 330                 335     


Phe Val Cys Ile Phe Ser Asn Arg Glu Leu Arg Arg Cys Phe Ser Thr 
            340                 345                 350         


Thr Leu Leu Tyr Cys Arg Lys Ser Arg Leu Pro Arg Glu Pro Tyr Cys 
        355                 360                 365             


Val Ile 
    370 


<210>  4540
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  4540

Met Ala Asn Ala Ser Glu Pro Gly Gly Ser Gly Gly Gly Glu Ala Ala 
1               5                   10                  15      


Ala Leu Gly Leu Lys Leu Ala Thr Leu Ser Leu Leu Leu Cys Val Ser 
            20                  25                  30          


Leu Ala Gly Asn Val Leu Phe Ala Leu Leu Ile Val Arg Glu Arg Ser 
        35                  40                  45              


Leu His Arg Ala Pro Tyr Tyr Leu Leu Leu Asp Leu Cys Leu Ala Asp 
    50                  55                  60                  


Gly Leu Arg Ala Leu Ala Cys Leu Pro Ala Val Met Leu Ala Ala Arg 
65                  70                  75                  80  


Arg Ala Ala Ala Ala Ala Gly Ala Pro Pro Gly Ala Leu Gly Cys Lys 
                85                  90                  95      


Leu Leu Ala Phe Leu Ala Ala Leu Phe Cys Phe His Ala Ala Phe Leu 
            100                 105                 110         


Leu Leu Gly Val Gly Val Thr Arg Tyr Leu Ala Ile Ala His His Arg 
        115                 120                 125             


Phe Tyr Ala Glu Arg Leu Ala Gly Trp Pro Cys Ala Ala Met Leu Val 
    130                 135                 140                 


Cys Ala Ala Trp Ala Leu Ala Leu Ala Ala Ala Phe Pro Pro Val Leu 
145                 150                 155                 160 


Asp Gly Gly Gly Asp Asp Glu Asp Ala Pro Cys Ala Leu Glu Gln Arg 
                165                 170                 175     


Pro Asp Gly Ala Pro Gly Ala Leu Gly Phe Leu Leu Leu Leu Ala Val 
            180                 185                 190         


Val Val Gly Ala Thr His Leu Val Tyr Leu Arg Leu Leu Phe Phe Ile 
        195                 200                 205             


His Asp Arg Arg Lys Met Arg Pro Ala Arg Leu Val Pro Ala Val Ser 
    210                 215                 220                 


His Asp Trp Thr Phe His Gly Pro Gly Ala Thr Gly Gln Ala Ala Ala 
225                 230                 235                 240 


Asn Trp Thr Ala Gly Phe Gly Arg Gly Pro Thr Pro Pro Ala Leu Val 
                245                 250                 255     


Gly Ile Arg Pro Ala Gly Pro Gly Arg Gly Ala Arg Arg Leu Leu Val 
            260                 265                 270         


Leu Glu Glu Phe Lys Thr Glu Lys Arg Leu Cys Lys Met Phe Tyr Ala 
        275                 280                 285             


Val Thr Leu Leu Phe Leu Leu Leu Trp Gly Pro Tyr Val Val Ala Ser 
    290                 295                 300                 


Tyr Leu Arg Val Leu Val Arg Pro Gly Ala Val Pro Gln Ala Tyr Leu 
305                 310                 315                 320 


Thr Ala Ser Val Trp Leu Thr Phe Ala Gln Ala Gly Ile Asn Pro Val 
                325                 330                 335     


Val Cys Phe Leu Phe Asn Arg Glu Leu Arg Asp Cys Phe Arg Ala Gln 
            340                 345                 350         


Phe Pro Cys Cys Gln Ser Pro Arg Thr Thr Gln Ala Thr His Pro Cys 
        355                 360                 365             


Asp Leu Lys Gly Ile Gly Leu 
    370                 375 


<210>  4541
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  4541

Met Ala Glu Arg Gln Glu Glu Gln Arg Gly Ser Pro Pro Leu Arg Ala 
1               5                   10                  15      


Glu Gly Lys Ala Asp Ala Glu Val Lys Leu Ile Leu Tyr His Trp Thr 
            20                  25                  30          


His Ser Phe Ser Ser Gln Lys Val Arg Leu Val Ile Ala Glu Lys Ala 
        35                  40                  45              


Leu Lys Cys Glu Glu His Asp Val Ser Leu Pro Leu Ser Glu His Asn 
    50                  55                  60                  


Glu Pro Trp Phe Met Arg Leu Asn Ser Thr Gly Glu Val Pro Val Leu 
65                  70                  75                  80  


Ile His Gly Glu Asn Ile Ile Cys Glu Ala Thr Gln Ile Ile Asp Tyr 
                85                  90                  95      


Leu Glu Gln Thr Phe Leu Asp Glu Arg Thr Pro Arg Leu Met Pro Asp 
            100                 105                 110         


Lys Glu Ser Met Tyr Tyr Pro Arg Val Gln His Tyr Arg Glu Leu Leu 
        115                 120                 125             


Asp Ser Leu Pro Met Asp Ala Tyr Thr His Gly Cys Ile Leu His Pro 
    130                 135                 140                 


Glu Leu Thr Val Asp Ser Met Ile Pro Ala Tyr Ala Thr Thr Arg Ile 
145                 150                 155                 160 


Arg Ser Gln Ile Gly Asn Thr Glu Ser Glu Leu Lys Lys Leu Ala Glu 
                165                 170                 175     


Glu Asn Pro Asp Leu Gln Glu Ala Tyr Ile Ala Lys Gln Lys Arg Leu 
            180                 185                 190         


Lys Ser Lys Leu Leu Asp His Asp Asn Val Lys Tyr Leu Lys Lys Ile 
        195                 200                 205             


Leu Asp Glu Leu Glu Lys Val Leu Asp Gln Val Glu Thr Glu Leu Gln 
    210                 215                 220                 


Arg Arg Asn Glu Glu Thr Pro Glu Glu Gly Gln Gln Pro Trp Leu Cys 
225                 230                 235                 240 


Gly Glu Ser Phe Thr Leu Ala Asp Val Ser Leu Ala Val Thr Leu His 
                245                 250                 255     


Arg Leu Lys Phe Leu Gly Phe Ala Arg Arg Asn Trp Gly Asn Gly Lys 
            260                 265                 270         


Arg Pro Asn Leu Glu Thr Tyr Tyr Glu Arg Val Leu Lys Arg Lys Thr 
        275                 280                 285             


Phe Asn Lys Val Leu Gly His Val Asn Asn Ile Leu Ile Ser Ala Val 
    290                 295                 300                 


Leu Pro Thr Ala Phe Arg Val Ala Lys Lys Arg Ala Pro Lys Val Leu 
305                 310                 315                 320 


Gly Thr Thr Leu Val Val Gly Leu Leu Ala Gly Val Gly Tyr Phe Ala 
                325                 330                 335     


Phe Met Leu Phe Arg Lys Arg Leu Gly Ser Met Ile Leu Ala Phe Arg 
            340                 345                 350         


Pro Arg Pro Asn Tyr Phe 
        355             


<210>  4542
<211>  506
<212>  PRT
<213>  Homo sapiens

<400>  4542

Met Lys Lys Ala Glu Met Gly Arg Phe Ser Ile Ser Pro Asp Glu Asp 
1               5                   10                  15      


Ser Ser Ser Tyr Ser Ser Asn Ser Asp Phe Asn Tyr Ser Tyr Pro Thr 
            20                  25                  30          


Lys Gln Ala Ala Leu Lys Ser His Tyr Ala Asp Val Asp Pro Glu Asn 
        35                  40                  45              


Gln Asn Phe Leu Leu Glu Ser Asn Leu Gly Lys Lys Lys Tyr Glu Thr 
    50                  55                  60                  


Glu Phe His Pro Gly Thr Thr Ser Phe Gly Met Ser Val Phe Asn Leu 
65                  70                  75                  80  


Ser Asn Ala Ile Val Gly Ser Gly Ile Leu Gly Leu Ser Tyr Ala Met 
                85                  90                  95      


Ala Asn Thr Gly Ile Ala Leu Phe Ile Ile Leu Leu Thr Phe Val Ser 
            100                 105                 110         


Ile Phe Ser Leu Tyr Ser Val His Leu Leu Leu Lys Thr Ala Asn Glu 
        115                 120                 125             


Gly Gly Ser Leu Leu Tyr Glu Gln Leu Gly Tyr Lys Ala Phe Gly Leu 
    130                 135                 140                 


Val Gly Lys Leu Ala Ala Ser Gly Ser Ile Thr Met Gln Asn Ile Gly 
145                 150                 155                 160 


Ala Met Ser Ser Tyr Leu Phe Ile Val Lys Tyr Glu Leu Pro Leu Val 
                165                 170                 175     


Ile Gln Ala Leu Thr Asn Ile Glu Asp Lys Thr Gly Leu Trp Tyr Leu 
            180                 185                 190         


Asn Gly Asn Tyr Leu Val Leu Leu Val Ser Leu Val Val Ile Leu Pro 
        195                 200                 205             


Leu Ser Leu Phe Arg Asn Leu Gly Tyr Leu Gly Tyr Thr Ser Gly Leu 
    210                 215                 220                 


Ser Leu Leu Cys Met Val Phe Phe Leu Ile Val Val Ile Cys Lys Lys 
225                 230                 235                 240 


Phe Gln Val Pro Cys Pro Val Glu Ala Ala Leu Ile Ile Asn Glu Thr 
                245                 250                 255     


Ile Asn Thr Thr Leu Thr Gln Pro Thr Ala Leu Val Pro Ala Leu Ser 
            260                 265                 270         


His Asn Val Thr Glu Asn Asp Ser Cys Arg Pro His Tyr Phe Ile Phe 
        275                 280                 285             


Asn Ser Gln Thr Val Tyr Ala Val Pro Ile Leu Ile Phe Ser Phe Val 
    290                 295                 300                 


Cys His Pro Ala Val Leu Pro Ile Tyr Glu Glu Leu Lys Asp Arg Ser 
305                 310                 315                 320 


Arg Arg Arg Met Met Asn Val Ser Lys Ile Ser Phe Phe Ala Met Phe 
                325                 330                 335     


Leu Met Tyr Leu Leu Ala Ala Leu Phe Gly Tyr Leu Thr Phe Tyr Glu 
            340                 345                 350         


His Val Glu Ser Glu Leu Leu His Thr Tyr Ser Ser Ile Leu Gly Thr 
        355                 360                 365             


Asp Ile Leu Leu Leu Ile Val Arg Leu Ala Val Leu Met Ala Val Thr 
    370                 375                 380                 


Leu Thr Val Pro Val Val Ile Phe Pro Ile Arg Ser Ser Val Thr His 
385                 390                 395                 400 


Leu Leu Cys Ala Ser Lys Asp Phe Ser Trp Trp Arg His Ser Leu Ile 
                405                 410                 415     


Thr Val Ser Ile Leu Ala Phe Thr Asn Leu Leu Val Ile Phe Val Pro 
            420                 425                 430         


Thr Ile Arg Asp Ile Phe Gly Phe Ile Gly Ala Ser Ala Ala Ser Met 
        435                 440                 445             


Leu Ile Phe Ile Leu Pro Ser Ala Phe Tyr Ile Lys Leu Val Lys Lys 
    450                 455                 460                 


Glu Pro Met Lys Ser Val Gln Lys Ile Gly Ala Leu Phe Phe Leu Leu 
465                 470                 475                 480 


Ser Gly Val Leu Val Met Thr Gly Ser Met Ala Leu Ile Val Leu Asp 
                485                 490                 495     


Trp Val His Asn Ala Pro Gly Gly Gly His 
            500                 505     


<210>  4543
<211>  828
<212>  PRT
<213>  Homo sapiens

<400>  4543

Met Trp Leu Arg Leu Gly Pro Pro Ser Leu Ser Leu Ser Pro Lys Pro 
1               5                   10                  15      


Thr Val Gly Arg Ser Leu Cys Leu Thr Leu Trp Phe Leu Ser Leu Ala 
            20                  25                  30          


Leu Arg Ala Ser Thr Gln Ala Pro Ala Pro Thr Val Asn Thr His Phe 
        35                  40                  45              


Gly Lys Leu Arg Gly Ala Arg Val Pro Leu Pro Ser Glu Ile Leu Gly 
    50                  55                  60                  


Pro Val Asp Gln Tyr Leu Gly Val Pro Tyr Ala Ala Pro Pro Ile Gly 
65                  70                  75                  80  


Glu Lys Arg Phe Leu Pro Pro Glu Pro Pro Pro Ser Trp Ser Gly Ile 
                85                  90                  95      


Arg Asn Ala Thr His Phe Pro Pro Val Cys Pro Gln Asn Ile His Thr 
            100                 105                 110         


Ala Val Pro Glu Val Met Leu Pro Val Trp Phe Thr Ala Asn Leu Asp 
        115                 120                 125             


Ile Val Ala Thr Tyr Ile Gln Glu Pro Asn Glu Asp Cys Leu Tyr Leu 
    130                 135                 140                 


Asn Val Tyr Val Pro Thr Glu Asp Gly Ser Gly Ala Lys Lys Gln Gly 
145                 150                 155                 160 


Glu Asp Leu Ala Asp Asn Asp Gly Asp Glu Asp Glu Asp Ile Arg Asp 
                165                 170                 175     


Ser Gly Ala Lys Pro Val Met Val Tyr Ile His Gly Gly Ser Tyr Met 
            180                 185                 190         


Glu Gly Thr Gly Asn Met Ile Asp Gly Ser Ile Leu Ala Ser Tyr Gly 
        195                 200                 205             


Asn Val Ile Val Ile Thr Leu Asn Tyr Arg Val Gly Val Leu Gly Phe 
    210                 215                 220                 


Leu Ser Thr Gly Asp Gln Ala Ala Lys Gly Asn Tyr Gly Leu Leu Asp 
225                 230                 235                 240 


Gln Ile Gln Ala Leu Arg Trp Val Ser Glu Asn Ile Ala Phe Phe Gly 
                245                 250                 255     


Gly Asp Pro Arg Arg Ile Thr Val Phe Gly Ser Gly Ile Gly Ala Ser 
            260                 265                 270         


Cys Val Ser Leu Leu Thr Leu Ser His His Ser Glu Gly Leu Phe Gln 
        275                 280                 285             


Arg Ala Ile Ile Gln Ser Gly Ser Ala Leu Ser Ser Trp Ala Val Asn 
    290                 295                 300                 


Tyr Gln Pro Val Lys Tyr Thr Ser Leu Leu Ala Asp Lys Val Gly Cys 
305                 310                 315                 320 


Asn Val Leu Asp Thr Val Asp Met Val Asp Cys Leu Arg Gln Lys Ser 
                325                 330                 335     


Ala Lys Glu Leu Val Glu Gln Asp Ile Gln Pro Ala Arg Tyr His Val 
            340                 345                 350         


Ala Phe Gly Pro Val Ile Asp Gly Asp Val Ile Pro Asp Asp Pro Glu 
        355                 360                 365             


Ile Leu Met Glu Gln Gly Glu Phe Leu Asn Tyr Asp Ile Met Leu Gly 
    370                 375                 380                 


Val Asn Gln Gly Glu Gly Leu Lys Phe Val Glu Gly Val Val Asp Pro 
385                 390                 395                 400 


Glu Asp Gly Val Ser Gly Thr Asp Phe Asp Tyr Ser Val Ser Asn Phe 
                405                 410                 415     


Val Asp Asn Leu Tyr Gly Tyr Pro Glu Gly Lys Asp Thr Leu Arg Glu 
            420                 425                 430         


Thr Ile Lys Phe Met Tyr Thr Asp Trp Ala Asp Arg Asp Asn Pro Glu 
        435                 440                 445             


Thr Arg Arg Lys Thr Leu Val Ala Leu Phe Thr Asp His Gln Trp Val 
    450                 455                 460                 


Glu Pro Ser Val Val Thr Ala Asp Leu His Ala Arg Tyr Gly Ser Pro 
465                 470                 475                 480 


Thr Tyr Phe Tyr Ala Phe Tyr His His Cys Gln Ser Leu Met Lys Pro 
                485                 490                 495     


Ala Trp Ser Asp Ala Ala His Gly Asp Glu Val Pro Tyr Val Phe Gly 
            500                 505                 510         


Val Pro Met Val Gly Pro Thr Asp Leu Phe Pro Cys Asn Phe Ser Lys 
        515                 520                 525             


Asn Asp Val Met Leu Ser Ala Val Val Met Thr Tyr Trp Thr Asn Phe 
    530                 535                 540                 


Ala Lys Thr Gly Asp Pro Asn Lys Pro Val Pro Gln Asp Thr Lys Phe 
545                 550                 555                 560 


Ile His Thr Lys Ala Asn Arg Phe Glu Glu Val Ala Trp Ser Lys Tyr 
                565                 570                 575     


Asn Pro Arg Asp Gln Leu Tyr Leu His Ile Gly Leu Lys Pro Arg Val 
            580                 585                 590         


Arg Asp His Tyr Arg Ala Thr Lys Val Ala Phe Trp Lys His Leu Val 
        595                 600                 605             


Pro His Leu Tyr Asn Leu His Asp Met Phe His Tyr Thr Ser Thr Thr 
    610                 615                 620                 


Thr Lys Val Pro Pro Pro Asp Thr Thr His Ser Ser His Ile Thr Arg 
625                 630                 635                 640 


Arg Pro Asn Gly Lys Thr Trp Ser Thr Lys Arg Pro Ala Ile Ser Pro 
                645                 650                 655     


Ala Tyr Ser Asn Glu Asn Ala Gln Gly Ser Trp Asn Gly Asp Gln Asp 
            660                 665                 670         


Ala Gly Pro Leu Leu Val Glu Asn Pro Arg Asp Tyr Ser Thr Glu Leu 
        675                 680                 685             


Ser Val Thr Ile Ala Val Gly Ala Ser Leu Leu Phe Leu Asn Val Leu 
    690                 695                 700                 


Ala Phe Ala Ala Leu Tyr Tyr Arg Lys Asp Lys Arg Arg Gln Glu Pro 
705                 710                 715                 720 


Leu Arg Gln Pro Ser Pro Gln Arg Gly Ala Gly Ala Pro Glu Leu Gly 
                725                 730                 735     


Ala Ala Pro Glu Glu Glu Leu Ala Ala Leu Gln Leu Gly Pro Thr His 
            740                 745                 750         


His Glu Cys Glu Ala Gly Pro Pro His Asp Thr Leu Arg Leu Thr Ala 
        755                 760                 765             


Leu Pro Asp Tyr Thr Leu Thr Leu Arg Arg Ser Pro Asp Asp Ile Pro 
    770                 775                 780                 


Leu Met Thr Pro Asn Thr Ile Thr Met Ile Pro Asn Ser Leu Val Gly 
785                 790                 795                 800 


Leu Gln Thr Leu His Pro Tyr Asn Thr Phe Ala Ala Gly Phe Asn Ser 
                805                 810                 815     


Thr Gly Leu Pro His Ser His Ser Thr Thr Arg Val 
            820                 825             


<210>  4544
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  4544

Met Leu Ser Ala Gly Leu Gly Leu Leu Met Leu Val Ala Val Val Glu 
1               5                   10                  15      


Phe Leu Ile Gly Leu Ile Gly Asn Gly Ser Leu Val Val Trp Ser Phe 
            20                  25                  30          


Arg Glu Trp Ile Arg Lys Phe Asn Trp Ser Ser Tyr Asn Leu Ile Ile 
        35                  40                  45              


Leu Gly Leu Ala Gly Cys Arg Phe Leu Leu Gln Trp Leu Ile Ile Leu 
    50                  55                  60                  


Asp Leu Ser Leu Phe Pro Leu Phe Gln Ser Ser Arg Trp Leu Arg Tyr 
65                  70                  75                  80  


Leu Ser Ile Phe Trp Val Leu Val Ser Gln Ala Ser Leu Trp Phe Ala 
                85                  90                  95      


Thr Phe Leu Ser Val Phe Tyr Cys Lys Lys Ile Thr Thr Phe Asp Arg 
            100                 105                 110         


Pro Ala Tyr Leu Trp Leu Lys Gln Arg Ala Tyr Asn Leu Ser Leu Trp 
        115                 120                 125             


Cys Leu Leu Gly Tyr Phe Ile Ile Asn Leu Leu Leu Thr Val Gln Ile 
    130                 135                 140                 


Gly Leu Thr Phe Tyr His Pro Pro Gln Gly Asn Ser Ser Ile Arg Tyr 
145                 150                 155                 160 


Pro Phe Glu Ser Trp Gln Tyr Leu Tyr Ala Phe Gln Leu Asn Ser Gly 
                165                 170                 175     


Ser Tyr Leu Pro Leu Val Val Phe Leu Val Ser Ser Gly Met Leu Ile 
            180                 185                 190         


Val Ser Leu Tyr Thr His His Lys Lys Met Lys Val His Ser Ala Gly 
        195                 200                 205             


Arg Arg Asp Val Arg Ala Lys Ala His Ile Thr Ala Leu Lys Ser Leu 
    210                 215                 220                 


Gly Cys Phe Leu Leu Leu His Leu Val Tyr Ile Met Ala Ser Pro Phe 
225                 230                 235                 240 


Ser Ile Thr Ser Lys Thr Tyr Pro Pro Asp Leu Thr Ser Val Phe Ile 
                245                 250                 255     


Trp Glu Thr Leu Met Ala Ala Tyr Pro Ser Leu His Ser Leu Ile Leu 
            260                 265                 270         


Ile Met Gly Ile Pro Arg Val Lys Gln Thr Cys Gln Lys Ile Leu Trp 
        275                 280                 285             


Lys Thr Val Cys Ala Arg Arg Cys Trp Gly Pro 
    290                 295                 


<210>  4545
<211>  793
<212>  PRT
<213>  Homo sapiens

<400>  4545

Met Gly Val Trp Leu Asn Lys Asp Asp Tyr Ile Arg Asp Leu Lys Arg 
1               5                   10                  15      


Ile Ile Leu Cys Phe Leu Ile Val Tyr Met Ala Ile Leu Val Gly Thr 
            20                  25                  30          


Asp Gln Asp Phe Tyr Ser Leu Leu Gly Val Ser Lys Thr Ala Ser Ser 
        35                  40                  45              


Arg Glu Ile Arg Gln Ala Phe Lys Lys Leu Ala Leu Lys Leu His Pro 
    50                  55                  60                  


Asp Lys Asn Pro Asn Asn Pro Asn Ala His Gly Asp Phe Leu Lys Ile 
65                  70                  75                  80  


Asn Arg Ala Tyr Glu Val Leu Lys Asp Glu Asp Leu Arg Lys Lys Tyr 
                85                  90                  95      


Asp Lys Tyr Gly Glu Lys Gly Leu Glu Asp Asn Gln Gly Gly Gln Tyr 
            100                 105                 110         


Glu Ser Trp Asn Tyr Tyr Arg Tyr Asp Phe Gly Ile Tyr Asp Asp Asp 
        115                 120                 125             


Pro Glu Ile Ile Thr Leu Glu Arg Arg Glu Phe Asp Ala Ala Val Asn 
    130                 135                 140                 


Ser Gly Glu Leu Trp Phe Val Asn Phe Tyr Ser Pro Gly Cys Ser His 
145                 150                 155                 160 


Cys His Asp Leu Ala Pro Thr Trp Arg Asp Phe Ala Lys Glu Val Asp 
                165                 170                 175     


Gly Leu Leu Arg Ile Gly Ala Val Asn Cys Gly Asp Asp Arg Met Leu 
            180                 185                 190         


Cys Arg Met Lys Gly Val Asn Ser Tyr Pro Ser Leu Phe Ile Phe Arg 
        195                 200                 205             


Ser Gly Met Ala Pro Val Lys Tyr His Gly Asp Arg Ser Lys Glu Ser 
    210                 215                 220                 


Leu Val Ser Phe Ala Met Gln His Val Arg Ser Thr Val Thr Glu Leu 
225                 230                 235                 240 


Trp Thr Gly Asn Phe Val Asn Ser Ile Gln Thr Ala Phe Ala Ala Gly 
                245                 250                 255     


Ile Gly Trp Leu Ile Thr Phe Cys Ser Lys Gly Gly Asp Cys Leu Thr 
            260                 265                 270         


Ser Gln Thr Arg Leu Arg Leu Ser Gly Met Leu Asp Gly Leu Val Asn 
        275                 280                 285             


Val Gly Trp Met Asp Cys Ala Thr Gln Asp Asn Leu Cys Lys Ser Leu 
    290                 295                 300                 


Asp Ile Thr Thr Ser Thr Thr Ala Tyr Phe Pro Pro Gly Ala Thr Leu 
305                 310                 315                 320 


Asn Asn Lys Glu Lys Asn Ser Ile Leu Phe Leu Asn Ser Leu Asp Ala 
                325                 330                 335     


Lys Glu Ile Tyr Leu Glu Val Ile His Asn Leu Pro Asp Phe Glu Leu 
            340                 345                 350         


Leu Ser Ala Asn Thr Leu Glu Asp Arg Leu Ala His His Arg Trp Leu 
        355                 360                 365             


Leu Phe Phe His Phe Gly Lys Asn Glu Asn Ser Asn Asp Pro Glu Leu 
    370                 375                 380                 


Lys Lys Leu Lys Thr Leu Leu Lys Asn Asp His Ile Gln Val Gly Arg 
385                 390                 395                 400 


Phe Asp Cys Ser Ser Ala Pro Asp Ile Cys Ser Asn Leu Tyr Val Phe 
                405                 410                 415     


Gln Pro Ser Leu Ala Val Phe Lys Gly Gln Gly Thr Lys Glu Tyr Glu 
            420                 425                 430         


Ile His His Gly Lys Lys Ile Leu Tyr Asp Ile Leu Ala Phe Ala Lys 
        435                 440                 445             


Glu Ser Val Asn Ser His Val Thr Thr Leu Gly Pro Gln Asn Phe Pro 
    450                 455                 460                 


Ala Asn Asp Lys Glu Pro Trp Leu Val Asp Phe Phe Ala Pro Trp Cys 
465                 470                 475                 480 


Pro Pro Cys Arg Ala Leu Leu Pro Glu Leu Arg Arg Ala Ser Asn Leu 
                485                 490                 495     


Leu Tyr Gly Gln Leu Lys Phe Gly Thr Leu Asp Cys Thr Val His Glu 
            500                 505                 510         


Gly Leu Cys Asn Met Tyr Asn Ile Gln Ala Tyr Pro Thr Thr Val Val 
        515                 520                 525             


Phe Asn Gln Ser Asn Ile His Glu Tyr Glu Gly His His Ser Ala Glu 
    530                 535                 540                 


Gln Ile Leu Glu Phe Ile Glu Asp Leu Met Asn Pro Ser Val Val Ser 
545                 550                 555                 560 


Leu Thr Pro Thr Thr Phe Asn Glu Leu Val Thr Gln Arg Lys His Asn 
                565                 570                 575     


Glu Val Trp Met Val Asp Phe Tyr Ser Pro Trp Cys His Pro Cys Gln 
            580                 585                 590         


Val Leu Met Pro Glu Trp Lys Arg Met Ala Arg Thr Leu Thr Gly Leu 
        595                 600                 605             


Ile Asn Val Gly Ser Ile Asp Cys Gln Gln Tyr His Ser Phe Cys Ala 
    610                 615                 620                 


Gln Glu Asn Val Gln Arg Tyr Pro Glu Ile Arg Phe Phe Pro Pro Lys 
625                 630                 635                 640 


Ser Asn Lys Ala Tyr His Tyr His Ser Tyr Asn Gly Trp Asn Arg Asp 
                645                 650                 655     


Ala Tyr Ser Leu Arg Ile Trp Gly Leu Gly Phe Leu Pro Gln Val Ser 
            660                 665                 670         


Thr Asp Leu Thr Pro Gln Thr Phe Ser Glu Lys Val Leu Gln Gly Lys 
        675                 680                 685             


Asn His Trp Val Ile Asp Phe Tyr Ala Pro Trp Cys Gly Pro Cys Gln 
    690                 695                 700                 


Asn Phe Ala Pro Glu Phe Glu Leu Leu Ala Arg Met Ile Lys Gly Lys 
705                 710                 715                 720 


Val Lys Ala Gly Lys Val Asp Cys Gln Ala Tyr Ala Gln Thr Cys Gln 
                725                 730                 735     


Lys Ala Gly Ile Arg Ala Tyr Pro Thr Val Lys Phe Tyr Phe Tyr Glu 
            740                 745                 750         


Arg Ala Lys Arg Asn Phe Gln Glu Glu Gln Ile Asn Thr Arg Asp Ala 
        755                 760                 765             


Lys Ala Ile Ala Ala Leu Ile Ser Glu Lys Leu Glu Thr Leu Arg Asn 
    770                 775                 780                 


Gln Gly Lys Arg Asn Lys Asp Glu Leu 
785                 790             


<210>  4546
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  4546

Met Ala Ala Val Asp Asp Leu Gln Phe Glu Glu Phe Gly Asn Ala Ala 
1               5                   10                  15      


Thr Ser Leu Thr Ala Asn Pro Asp Ala Thr Thr Val Asn Ile Glu Asp 
            20                  25                  30          


Pro Gly Glu Thr Pro Lys His Gln Pro Gly Ser Pro Arg Gly Ser Gly 
        35                  40                  45              


Arg Glu Glu Asp Asp Glu Leu Leu Gly Asn Asp Asp Ser Asp Lys Thr 
    50                  55                  60                  


Glu Leu Leu Ala Gly Gln Lys Lys Ser Ser Pro Phe Trp Thr Phe Glu 
65                  70                  75                  80  


Tyr Tyr Gln Thr Phe Phe Asp Val Asp Thr Tyr Gln Val Phe Asp Arg 
                85                  90                  95      


Ile Lys Gly Ser Leu Leu Pro Ile Pro Gly Lys Asn Phe Val Arg Leu 
            100                 105                 110         


Tyr Ile Arg Ser Asn Pro Asp Leu Tyr Gly Pro Phe Trp Ile Cys Ala 
        115                 120                 125             


Thr Leu Val Phe Ala Ile Ala Ile Ser Gly Asn Leu Ser Asn Phe Leu 
    130                 135                 140                 


Ile His Leu Gly Glu Lys Thr Tyr His Tyr Val Pro Glu Phe Arg Lys 
145                 150                 155                 160 


Val Ser Ile Ala Ala Thr Ile Ile Tyr Ala Tyr Ala Trp Leu Val Pro 
                165                 170                 175     


Leu Ala Leu Trp Gly Phe Leu Met Trp Arg Asn Ser Lys Val Met Asn 
            180                 185                 190         


Ile Val Ser Tyr Ser Phe Leu Glu Ile Val Cys Val Tyr Gly Tyr Ser 
        195                 200                 205             


Leu Phe Ile Tyr Ile Pro Thr Ala Ile Leu Trp Ile Ile Pro Gln Lys 
    210                 215                 220                 


Ala Val Arg Trp Ile Leu Val Met Ile Ala Leu Gly Ile Ser Gly Ser 
225                 230                 235                 240 


Leu Leu Ala Met Thr Phe Trp Pro Ala Val Arg Glu Asp Asn Arg Arg 
                245                 250                 255     


Val Ala Leu Ala Thr Ile Val Thr Ile Val Leu Leu His Met Leu Leu 
            260                 265                 270         


Ser Val Gly Cys Leu Ala Tyr Phe Phe Asp Ala Pro Glu Met Asp His 
        275                 280                 285             


Leu Pro Thr Thr Thr Ala Thr Pro Asn Gln Thr Val Ala Ala Ala Lys 
    290                 295                 300                 


Ser Ser 
305     


<210>  4547
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  4547

Met Pro Glu Gly Glu Asp Phe Gly Pro Gly Lys Ser Trp Glu Val Ile 
1               5                   10                  15      


Asn Ser Lys Pro Asp Glu Arg Pro Arg Leu Ser His Cys Ile Ala Glu 
            20                  25                  30          


Ser Trp Met Asn Phe Ser Ile Phe Leu Gln Glu Met Ser Leu Phe Lys 
        35                  40                  45              


Gln Gln Ser Pro Gly Lys Phe Cys Leu Leu Val Cys Ser Val Cys Thr 
    50                  55                  60                  


Phe Phe Thr Ile Leu Gly Ser Tyr Ile Pro Gly Val Ile Leu Ser Tyr 
65                  70                  75                  80  


Leu Leu Leu Leu Cys Ala Phe Leu Cys Pro Leu Phe Lys Cys Asn Asp 
                85                  90                  95      


Ile Gly Gln Lys Ile Tyr Ser Lys Ile Lys Ser Val Leu Leu Lys Leu 
            100                 105                 110         


Asp Phe Gly Ile Gly Glu Tyr Ile Asn Gln Lys Lys Arg Glu Arg Ser 
        115                 120                 125             


Glu Ala Asp Lys Glu Lys Ser His Lys Asp Asp Ser Glu Leu Asp Phe 
    130                 135                 140                 


Ser Ala Leu Cys Pro Lys Ile Ser Leu Thr Val Ala Ala Lys Glu Leu 
145                 150                 155                 160 


Ser Val Ser Asp Thr Asp Val Ser Glu Val Ser Trp Thr Asp Asn Gly 
                165                 170                 175     


Thr Phe Asn Leu Ser Glu Gly Tyr Thr Pro Gln Thr Asp Thr Ser Asp 
            180                 185                 190         


Asp Leu Asp Arg Pro Ser Glu Glu Val Phe Ser Arg Asp Leu Ser Asp 
        195                 200                 205             


Phe Pro Ser Leu Glu Asn Gly Met Gly Thr Asn Asp Glu Asp Glu Leu 
    210                 215                 220                 


Ser Leu Gly Leu Pro Thr Glu Leu Lys Arg Lys Lys Glu Gln Leu Asp 
225                 230                 235                 240 


Ser Gly His Arg Pro Ser Lys Glu Thr Gln Ser Ala Ala Gly Leu Thr 
                245                 250                 255     


Leu Pro Leu Asn Ser Asp Gln Thr Phe His Leu Met Ser Asn Leu Ala 
            260                 265                 270         


Gly Asp Val Ile Thr Ala Ala Val Thr Ala Ala Ile Lys Asp Gln Leu 
        275                 280                 285             


Glu Gly Val Gln Gln Ala Leu Ser Gln Ala Ala Pro Ile Pro Glu Glu 
    290                 295                 300                 


Asp Thr Asp Thr Glu Glu Gly Asp Asp Phe Glu Leu Leu Asp Gln Ser 
305                 310                 315                 320 


Glu Leu Asp Gln Ile Glu Ser Glu Leu Gly Leu Thr Gln Asp Gln Glu 
                325                 330                 335     


Ala Glu Ala Gln Gln Asn Lys Lys Ser Ser Gly Phe Leu Ser Asn Leu 
            340                 345                 350         


Leu Gly Gly His 
        355     


<210>  4548
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  4548

Met Ala Ala Thr Arg Ser Pro Thr Arg Ala Arg Glu Arg Glu Arg Ser 
1               5                   10                  15      


Gly Ala Pro Ala Ala Gly Ser Asp Gln Val His Ser Trp Met Leu Ala 
            20                  25                  30          


Thr Ser Gln Ala Leu Asp Thr Val Trp Arg Met Ala Lys Gly Phe Val 
        35                  40                  45              


Met Leu Ala Val Ser Phe Leu Val Ala Ala Ile Cys Tyr Phe Arg Arg 
    50                  55                  60                  


Leu His Leu Tyr Ser Gly His Lys Leu Lys Trp Trp Ile Gly Tyr Leu 
65                  70                  75                  80  


Gln Arg Lys Phe Lys Arg Asn Leu Ser Val Glu Ala Glu Val Asp Leu 
                85                  90                  95      


Leu Ser Tyr Cys Ala Arg Glu Trp Lys Gly Glu Thr Pro Arg Asn Lys 
            100                 105                 110         


Leu Met Arg Lys Ala Tyr Glu Glu Leu Phe Trp Arg His His Ile Lys 
        115                 120                 125             


Cys Val Arg Gln Val Arg Arg Asp Asn Tyr Asp Ala Leu Arg Ser Val 
    130                 135                 140                 


Leu Phe Gln Ile Phe Ser Gln Gly Ile Ser Phe Pro Ser Trp Met Lys 
145                 150                 155                 160 


Glu Lys Asp Ile Val Lys Leu Pro Glu Lys Leu Leu Phe Ser Gln Gly 
                165                 170                 175     


Cys Asn Trp Ile Gln Gln Tyr Ser Phe Gly Pro Glu Lys Tyr Thr Gly 
            180                 185                 190         


Ser Asn Val Phe Gly Lys Leu Arg Lys Tyr Val Glu Leu Leu Lys Thr 
        195                 200                 205             


Gln Trp Thr Glu Phe Asn Gly Ile Arg Asp Tyr His Lys Arg Gly Ser 
    210                 215                 220                 


Met Cys Asn Thr Leu Phe Ser Asp Ala Ile Leu Glu Tyr Lys Leu Tyr 
225                 230                 235                 240 


Glu Ala Leu Lys Phe Ile Met Leu Tyr Gln Val Thr Glu Val Tyr Glu 
                245                 250                 255     


Gln Met Lys Thr Lys Lys Val Ile Pro Ser Leu Phe Arg Leu Leu Phe 
            260                 265                 270         


Ser Arg Glu Thr Ser Ser Asp Pro Leu Ser Phe Met Met Asn His Leu 
        275                 280                 285             


Asn Ser Val Gly Asp Thr Cys Gly Leu Glu Gln Ile Asp Met Phe Ile 
    290                 295                 300                 


Leu Gly Tyr Ser Leu Glu Val Lys Ile Lys Val Phe Arg Leu Phe Lys 
305                 310                 315                 320 


Phe Asn Ser Arg Asp Phe Glu Val Cys Tyr Pro Glu Glu Pro Leu Arg 
                325                 330                 335     


Asp Trp Pro Glu Ile Ser Leu Leu Thr Glu Asn Asp Arg His Tyr His 
            340                 345                 350         


Ile Pro Val Phe 
        355     


<210>  4549
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  4549

Met Ala Ala Trp Lys Ser Trp Thr Ala Leu Arg Leu Cys Ala Thr Val 
1               5                   10                  15      


Val Val Leu Asp Met Val Val Cys Lys Gly Phe Val Glu Asp Leu Asp 
            20                  25                  30          


Glu Ser Phe Lys Glu Asn Arg Asn Asp Asp Ile Trp Leu Val Asp Phe 
        35                  40                  45              


Tyr Ala Pro Trp Cys Gly His Cys Lys Lys Leu Glu Pro Ile Trp Asn 
    50                  55                  60                  


Glu Val Gly Leu Glu Met Lys Ser Ile Gly Ser Pro Val Lys Val Gly 
65                  70                  75                  80  


Lys Met Asp Ala Thr Ser Tyr Ser Ser Ile Ala Ser Glu Phe Gly Val 
                85                  90                  95      


Arg Gly Tyr Pro Thr Ile Lys Leu Leu Lys Gly Asp Leu Ala Tyr Asn 
            100                 105                 110         


Tyr Arg Gly Pro Arg Thr Lys Asp Asp Ile Ile Glu Phe Ala His Arg 
        115                 120                 125             


Val Ser Gly Ala Leu Ile Arg Pro Leu Pro Ser Gln Gln Met Phe Glu 
    130                 135                 140                 


His Met Gln Lys Arg His Arg Val Phe Phe Val Tyr Val Gly Gly Glu 
145                 150                 155                 160 


Ser Pro Leu Lys Glu Lys Tyr Ile Asp Ala Ala Ser Glu Leu Ile Val 
                165                 170                 175     


Tyr Thr Tyr Phe Phe Ser Ala Ser Glu Glu Val Val Pro Glu Tyr Val 
            180                 185                 190         


Thr Leu Lys Glu Met Pro Ala Val Leu Val Phe Lys Asp Glu Thr Tyr 
        195                 200                 205             


Phe Val Tyr Asp Glu Tyr Glu Asp Gly Asp Leu Ser Ser Trp Ile Asn 
    210                 215                 220                 


Arg Glu Arg Phe Gln Asn Tyr Leu Ala Met Asp Gly Phe Leu Leu Tyr 
225                 230                 235                 240 


Glu Leu Gly Asp Thr Gly Lys Leu Val Ala Leu Ala Val Ile Asp Glu 
                245                 250                 255     


Lys Asn Thr Ser Val Glu His Thr Arg Leu Lys Ser Ile Ile Gln Glu 
            260                 265                 270         


Val Ala Arg Asp Tyr Arg Asp Leu Phe His Arg Asp Phe Gln Phe Gly 
        275                 280                 285             


His Met Asp Gly Asn Asp Tyr Ile Asn Thr Leu Leu Met Asp Glu Leu 
    290                 295                 300                 


Thr Val Pro Thr Val Val Val Leu Asn Thr Ser Asn Gln Gln Tyr Phe 
305                 310                 315                 320 


Leu Leu Asp Arg Gln Ile Lys Asn Val Glu Asp Met Val Gln Phe Ile 
                325                 330                 335     


Asn Asn Ile Leu Asp Gly Thr Val Glu Ala Gln Gly Gly Asp Ser Ile 
            340                 345                 350         


Leu Gln Arg Leu Lys Arg Ile Val Phe Asp Ala Lys Ser Thr Ile Val 
        355                 360                 365             


Ser Ile Phe Lys Ser Ser Pro Leu Met Gly Cys Phe Leu Phe Gly Leu 
    370                 375                 380                 


Pro Leu Gly Val Ile Ser Ile Met Cys Tyr Gly Ile Tyr Thr Ala Asp 
385                 390                 395                 400 


Thr Asp Gly Gly Tyr Ile Glu Glu Arg Tyr Glu Val Ser Lys Ser Glu 
                405                 410                 415     


Asn Glu Asn Gln Glu Gln Ile Glu Glu Ser Lys Glu Gln Gln Glu Pro 
            420                 425                 430         


Ser Ser Gly Gly Ser Val Val Pro Thr Val Gln Glu Pro Lys Asp Val 
        435                 440                 445             


Leu Glu Lys Lys Lys Asp 
    450                 


<210>  4550
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  4550

Met Pro Arg Lys Arg Lys Cys Asp Leu Arg Ala Val Arg Val Gly Leu 
1               5                   10                  15      


Leu Leu Gly Gly Gly Gly Val Tyr Gly Ser Arg Phe Arg Phe Thr Phe 
            20                  25                  30          


Pro Gly Cys Arg Ala Leu Ser Pro Trp Arg Val Arg Val Gln Arg Arg 
        35                  40                  45              


Arg Cys Glu Met Ser Thr Met Phe Ala Asp Thr Leu Leu Ile Val Phe 
    50                  55                  60                  


Ile Ser Val Cys Thr Ala Leu Leu Ala Glu Gly Ile Thr Trp Val Leu 
65                  70                  75                  80  


Val Tyr Arg Thr Asp Lys Tyr Lys Arg Leu Lys Ala Glu Val Glu Lys 
                85                  90                  95      


Gln Ser Lys Lys Leu Glu Lys Lys Lys Glu Thr Ile Thr Glu Ser Ala 
            100                 105                 110         


Gly Arg Gln Gln Lys Lys Lys Ile Glu Arg Gln Glu Glu Lys Leu Lys 
        115                 120                 125             


Asn Asn Asn Arg Asp Leu Ser Met Val Arg Met Lys Ser Met Phe Ala 
    130                 135                 140                 


Ile Gly Phe Cys Phe Thr Ala Leu Met Gly Met Phe Asn Ser Ile Phe 
145                 150                 155                 160 


Asp Gly Arg Val Val Ala Lys Leu Pro Phe Thr Pro Leu Ser Tyr Ile 
                165                 170                 175     


Gln Gly Leu Ser His Arg Asn Leu Leu Gly Asp Asp Thr Thr Asp Cys 
            180                 185                 190         


Ser Phe Ile Phe Leu Tyr Ile Leu Cys Thr Met Ser Ile Arg Gln Asn 
        195                 200                 205             


Ile Gln Lys Ile Leu Gly Leu Ala Pro Ser Arg Ala Ala Thr Lys Gln 
    210                 215                 220                 


Ala Gly Gly Phe Leu Gly Pro Pro Pro Pro Ser Gly Lys Phe Ser 
225                 230                 235                 


<210>  4551
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  4551

Met Glu Gly Pro Gly Leu Gly Ser Gln Cys Arg Asn His Ser His Gly 
1               5                   10                  15      


Pro His Pro Pro Gly Phe Gly Arg Tyr Gly Ile Cys Ala His Glu Asn 
            20                  25                  30          


Lys Glu Leu Ala Asn Ala Arg Glu Ala Leu Pro Leu Ile Glu Asp Ser 
        35                  40                  45              


Ser Asn Cys Asp Ile Val Lys Ala Thr Gln Tyr Gly Ile Phe Glu Arg 
    50                  55                  60                  


Cys Lys Glu Leu Val Glu Ala Gly Tyr Asp Val Arg Gln Pro Asp Lys 
65                  70                  75                  80  


Glu Asn Val Ser Leu Leu His Trp Ala Ala Ile Asn Asn Arg Leu Asp 
                85                  90                  95      


Leu Val Lys Phe Tyr Ile Ser Lys Gly Ala Val Val Asp Gln Leu Gly 
            100                 105                 110         


Gly Asp Leu Asn Ser Thr Pro Leu His Trp Ala Ile Arg Gln Gly His 
        115                 120                 125             


Leu Pro Met Val Ile Leu Leu Leu Gln His Gly Ala Asp Pro Thr Leu 
    130                 135                 140                 


Ile Asp Gly Glu Gly Phe Ser Ser Ile His Leu Ala Val Leu Phe Gln 
145                 150                 155                 160 


His Met Pro Ile Ile Ala Tyr Leu Ile Ser Lys Gly Gln Ser Val Asn 
                165                 170                 175     


Met Thr Asp Val Asn Gly Gln Thr Pro Leu Met Leu Ser Ala His Lys 
            180                 185                 190         


Val Ile Gly Pro Glu Pro Thr Gly Phe Leu Leu Lys Phe Asn Pro Ser 
        195                 200                 205             


Leu Asn Val Val Asp Lys Ile His Gln Asn Thr Pro Leu His Trp Ala 
    210                 215                 220                 


Val Ala Ala Gly Asn Val Asn Ala Val Asp Lys Leu Leu Glu Ala Gly 
225                 230                 235                 240 


Ser Ser Leu Asp Ile Gln Asn Val Lys Gly Glu Thr Pro Leu Asp Met 
                245                 250                 255     


Ala Leu Gln Asn Lys Asn Gln Leu Ile Ile His Met Leu Lys Thr Glu 
            260                 265                 270         


Ala Lys Met Arg Ala Asn Gln Lys Phe Arg Leu Trp Arg Trp Leu Gln 
        275                 280                 285             


Lys Cys Glu Leu Phe Leu Leu Leu Met Leu Ser Val Ile Thr Met Trp 
    290                 295                 300                 


Ala Ile Gly Tyr Ile Leu Asp Phe Asn Ser Asp Ser Trp Leu Leu Lys 
305                 310                 315                 320 


Gly Cys Leu Leu Val Thr Leu Phe Phe Leu Thr Ser Leu Phe Pro Arg 
                325                 330                 335     


Phe Leu Val Gly Tyr Lys Asn Leu Val Tyr Leu Pro Thr Ala Phe Leu 
            340                 345                 350         


Leu Ser Ser Val Phe Trp Ile Phe Met Thr Trp Phe Ile Leu Phe Phe 
        355                 360                 365             


Pro Asp Leu Ala Gly Ala Pro Phe Tyr Phe Ser Phe Ile Phe Ser Ile 
    370                 375                 380                 


Val Ala Phe Leu Tyr Phe Phe Tyr Lys Thr Trp Ala Thr Asp Pro Gly 
385                 390                 395                 400 


Phe Thr Lys Ala Ser Glu Glu Glu Lys Lys Val Asn Ile Ile Thr Leu 
                405                 410                 415     


Ala Glu Thr Gly Ser Leu Asp Phe Arg Thr Phe Cys Thr Ser Cys Leu 
            420                 425                 430         


Ile Arg Lys Pro Leu Arg Ser Leu His Cys His Val Cys Asn Cys Cys 
        435                 440                 445             


Val Ala Arg Tyr Asp Gln His Cys Leu Trp Thr Gly Arg Cys Ile Gly 
    450                 455                 460                 


Phe Gly Asn His His Tyr Tyr Ile Phe Phe Leu Phe Phe Leu Ser Met 
465                 470                 475                 480 


Val Cys Gly Trp Ile Ile Tyr Gly Ser Phe Ile Tyr Leu Ser Ser His 
                485                 490                 495     


Cys Ala Thr Thr Phe Lys Glu Asp Gly Leu Trp Thr Tyr Leu Asn Gln 
            500                 505                 510         


Ile Val Ala Cys Ser Pro Trp Val Leu Tyr Ile Leu Met Leu Ala Thr 
        515                 520                 525             


Phe His Phe Ser Trp Ser Thr Phe Leu Leu Leu Asn Gln Leu Phe Gln 
    530                 535                 540                 


Ile Ala Phe Leu Gly Leu Thr Ser His Glu Arg Ile Ser Leu Gln Lys 
545                 550                 555                 560 


Gln Ser Lys His Met Lys Gln Thr Leu Ser Leu Arg Lys Thr Pro Tyr 
                565                 570                 575     


Asn Leu Gly Phe Met Gln Asn Leu Ala Asp Phe Phe Gln Cys Gly Cys 
            580                 585                 590         


Phe Gly Leu Val Lys Pro Cys Val Val Asp Trp Thr Ser Gln Tyr Thr 
        595                 600                 605             


Met Val Phe His Pro Ala Arg Glu Lys Val Leu Arg Ser Val 
    610                 615                 620         


<210>  4552
<211>  1135
<212>  PRT
<213>  Homo sapiens

<400>  4552

Met His Gln Met Asn Ala Lys Met His Phe Arg Phe Val Phe Ala Leu 
1               5                   10                  15      


Leu Ile Val Ser Phe Asn His Asp Val Leu Gly Lys Asn Leu Lys Tyr 
            20                  25                  30          


Arg Ile Tyr Glu Glu Gln Arg Val Gly Ser Val Ile Ala Arg Leu Ser 
        35                  40                  45              


Glu Asp Val Ala Asp Val Leu Leu Lys Leu Pro Asn Pro Ser Thr Val 
    50                  55                  60                  


Arg Phe Arg Ala Met Gln Arg Gly Asn Ser Pro Leu Leu Val Val Asn 
65                  70                  75                  80  


Glu Asp Asn Gly Glu Ile Ser Ile Gly Ala Thr Ile Asp Arg Glu Gln 
                85                  90                  95      


Leu Cys Gln Lys Asn Leu Asn Cys Ser Ile Glu Phe Asp Val Ile Thr 
            100                 105                 110         


Leu Pro Thr Glu His Leu Gln Leu Phe His Ile Glu Val Glu Val Leu 
        115                 120                 125             


Asp Ile Asn Asp Asn Ser Pro Gln Phe Ser Arg Ser Leu Ile Pro Ile 
    130                 135                 140                 


Glu Ile Ser Glu Ser Ala Ala Val Gly Thr Arg Ile Pro Leu Asp Ser 
145                 150                 155                 160 


Ala Phe Asp Pro Asp Val Gly Glu Asn Ser Leu His Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ala Asn Asp Phe Phe Asn Ile Glu Val Arg Thr Arg Thr Asp Gly 
            180                 185                 190         


Ala Lys Tyr Ala Glu Leu Ile Val Val Arg Glu Leu Asp Arg Glu Leu 
        195                 200                 205             


Lys Ser Ser Tyr Glu Leu Gln Leu Thr Ala Ser Asp Met Gly Val Pro 
    210                 215                 220                 


Gln Arg Ser Gly Ser Ser Ile Leu Lys Ile Ser Ile Ser Asp Ser Asn 
225                 230                 235                 240 


Asp Asn Ser Pro Ala Phe Glu Gln Gln Ser Tyr Ile Ile Gln Leu Leu 
                245                 250                 255     


Glu Asn Ser Pro Val Gly Thr Leu Leu Leu Asp Leu Asn Ala Thr Asp 
            260                 265                 270         


Pro Asp Glu Gly Ala Asn Gly Lys Ile Val Tyr Ser Phe Ser Ser His 
        275                 280                 285             


Val Ser Pro Lys Ile Met Glu Thr Phe Lys Ile Asp Ser Glu Arg Gly 
    290                 295                 300                 


His Leu Thr Leu Phe Lys Gln Val Asp Tyr Glu Ile Thr Lys Ser Tyr 
305                 310                 315                 320 


Glu Ile Asp Val Gln Ala Gln Asp Leu Gly Pro Asn Ser Ile Pro Ala 
                325                 330                 335     


His Cys Lys Ile Ile Ile Lys Val Val Asp Val Asn Asp Asn Lys Pro 
            340                 345                 350         


Glu Ile Asn Ile Asn Leu Met Ser Pro Gly Lys Glu Glu Ile Ser Tyr 
        355                 360                 365             


Ile Phe Glu Gly Asp Pro Ile Asp Thr Phe Val Ala Leu Val Arg Val 
    370                 375                 380                 


Gln Asp Lys Asp Ser Gly Leu Asn Gly Glu Ile Val Cys Lys Leu His 
385                 390                 395                 400 


Gly His Gly His Phe Lys Leu Gln Lys Thr Tyr Glu Asn Asn Tyr Leu 
                405                 410                 415     


Ile Leu Thr Asn Ala Thr Leu Asp Arg Glu Lys Arg Ser Glu Tyr Ser 
            420                 425                 430         


Leu Thr Val Ile Ala Glu Asp Arg Gly Thr Pro Ser Leu Ser Thr Val 
        435                 440                 445             


Lys His Phe Thr Val Gln Ile Asn Asp Ile Asn Asp Asn Pro Pro His 
    450                 455                 460                 


Phe Gln Arg Ser Arg Tyr Glu Phe Val Ile Ser Glu Asn Asn Ser Pro 
465                 470                 475                 480 


Gly Ala Tyr Ile Thr Thr Val Thr Ala Thr Asp Pro Asp Leu Gly Glu 
                485                 490                 495     


Asn Gly Gln Val Thr Tyr Thr Ile Leu Glu Ser Phe Ile Leu Gly Ser 
            500                 505                 510         


Ser Ile Thr Thr Tyr Val Thr Ile Asp Pro Ser Asn Gly Ala Ile Tyr 
        515                 520                 525             


Ala Leu Arg Ile Phe Asp His Glu Glu Val Ser Gln Ile Thr Phe Val 
    530                 535                 540                 


Val Glu Ala Arg Asp Gly Gly Ser Pro Lys Gln Leu Val Ser Asn Thr 
545                 550                 555                 560 


Thr Val Val Leu Thr Ile Ile Asp Glu Asn Asp Asn Val Pro Val Val 
                565                 570                 575     


Ile Gly Pro Ala Leu Arg Asn Asn Thr Ala Glu Ile Thr Ile Pro Lys 
            580                 585                 590         


Gly Ala Glu Ser Gly Phe His Val Thr Arg Ile Arg Ala Ile Asp Arg 
        595                 600                 605             


Asp Ser Gly Val Asn Ala Glu Leu Ser Cys Ala Ile Val Ala Gly Asn 
    610                 615                 620                 


Glu Glu Asn Ile Phe Ile Ile Asp Pro Arg Ser Cys Asp Ile His Thr 
625                 630                 635                 640 


Asn Val Ser Met Asp Ser Val Pro Tyr Thr Glu Trp Glu Leu Ser Val 
                645                 650                 655     


Ile Ile Gln Asp Lys Gly Asn Pro Gln Leu His Thr Lys Val Leu Leu 
            660                 665                 670         


Lys Cys Met Ile Phe Glu Tyr Ala Glu Ser Val Thr Ser Thr Ala Met 
        675                 680                 685             


Thr Ser Val Ser Gln Ala Ser Leu Asp Val Ser Met Ile Ile Ile Ile 
    690                 695                 700                 


Ser Leu Gly Ala Ile Cys Ala Val Leu Leu Val Ile Met Val Leu Phe 
705                 710                 715                 720 


Ala Thr Arg Cys Asn Arg Glu Lys Lys Asp Thr Arg Ser Tyr Asn Cys 
                725                 730                 735     


Arg Val Ala Glu Ser Thr Tyr Gln His His Pro Lys Arg Pro Ser Arg 
            740                 745                 750         


Gln Ile His Lys Gly Asp Ile Thr Leu Val Pro Thr Ile Asn Gly Thr 
        755                 760                 765             


Leu Pro Ile Arg Ser His His Arg Ser Ser Pro Ser Ser Ser Pro Thr 
    770                 775                 780                 


Leu Glu Arg Gly Gln Met Gly Ser Arg Gln Ser His Asn Ser His Gln 
785                 790                 795                 800 


Ser Leu Asn Ser Leu Val Thr Ile Ser Ser Asn His Val Pro Glu Asn 
                805                 810                 815     


Phe Ser Leu Glu Leu Thr His Ala Thr Pro Ala Val Glu Gln Val Ser 
            820                 825                 830         


Gln Leu Leu Ser Met Leu His Gln Gly Gln Tyr Gln Pro Arg Pro Ser 
        835                 840                 845             


Phe Arg Gly Asn Lys Tyr Ser Arg Ser Tyr Arg Tyr Ala Leu Gln Asp 
    850                 855                 860                 


Met Asp Lys Phe Ser Leu Lys Asp Ser Gly Arg Gly Asp Ser Glu Ala 
865                 870                 875                 880 


Gly Asp Ser Asp Tyr Asp Leu Gly Arg Asp Ser Pro Ile Asp Arg Leu 
                885                 890                 895     


Leu Gly Glu Gly Phe Ser Asp Leu Phe Leu Thr Asp Gly Arg Ile Pro 
            900                 905                 910         


Ala Ala Met Arg Leu Cys Thr Glu Glu Cys Arg Val Leu Gly His Ser 
        915                 920                 925             


Asp Gln Cys Trp Met Pro Pro Leu Pro Ser Pro Ser Ser Asp Tyr Arg 
    930                 935                 940                 


Ser Asn Met Phe Ile Pro Gly Glu Glu Phe Pro Thr Gln Pro Gln Gln 
945                 950                 955                 960 


Gln His Pro His Gln Ser Leu Glu Asp Asp Ala Gln Pro Ala Asp Ser 
                965                 970                 975     


Gly Glu Lys Lys Lys Ser Phe Ser Thr Phe Gly Lys Asp Ser Pro Asn 
            980                 985                 990         


Asp Glu Asp Thr Gly Asp Thr Ser  Thr Ser Ser Leu Leu  Ser Glu Met 
        995                 1000                 1005             


Ser Ser  Val Phe Gln Arg Leu  Leu Pro Pro Ser Leu  Asp Thr Tyr 
    1010                 1015                 1020             


Ser Glu  Cys Ser Glu Val Asp  Arg Ser Asn Ser Leu  Glu Arg Arg 
    1025                 1030                 1035             


Lys Gly  Pro Leu Pro Ala Lys  Thr Val Gly Tyr Pro  Gln Gly Val 
    1040                 1045                 1050             


Ala Ala  Trp Ala Ala Ser Thr  His Phe Gln Asn Pro  Thr Thr Asn 
    1055                 1060                 1065             


Cys Gly  Pro Pro Leu Gly Thr  His Ser Ser Val Gln  Pro Ser Ser 
    1070                 1075                 1080             


Lys Trp  Leu Pro Ala Met Glu  Glu Ile Pro Glu Asn  Tyr Glu Glu 
    1085                 1090                 1095             


Asp Asp  Phe Asp Asn Val Leu  Asn His Leu Asn Asp  Gly Lys His 
    1100                 1105                 1110             


Glu Leu  Met Asp Ala Ser Glu  Leu Val Ala Glu Ile  Asn Lys Leu 
    1115                 1120                 1125             


Leu Gln  Asp Val Arg Gln Ser  
    1130                 1135 


<210>  4553
<211>  42
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<400>  4553

Asx Glu Thr Ala Ser Asx Cys Met Pro Leu Glu Xaa Ser Asx Asn Ile 
1               5                   10                  15      


Thr Met Ile Thr Cys His Asn Asp Arg Ile Ala Leu Ile Ser Phe Arg 
            20                  25                  30          


Met His Met Ser Ala Pro Ile Glu Asn Ser 
        35                  40          


<210>  4554
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  4554

Met Val Lys Leu Ser Lys Glu Ala Lys Gln Arg Leu Gln Gln Leu Phe 
1               5                   10                  15      


Lys Gly Ser Gln Phe Ala Ile Arg Trp Gly Phe Ile Pro Leu Val Ile 
            20                  25                  30          


Tyr Leu Gly Phe Lys Arg Gly Ala Asp Pro Gly Met Pro Glu Pro Thr 
        35                  40                  45              


Val Leu Ser Leu Leu Trp Gly 
    50                  55  


<210>  4555
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  4555

Met Ala Cys Thr Lys Thr Leu Gln Gln Ser Gln Pro Ile Ser Ala Gly 
1               5                   10                  15      


Ala Thr Thr Thr Thr Thr Ala Val Ala Pro Ala Gly Gly His Ser Gly 
            20                  25                  30          


Ser Thr Glu Cys Asp Leu Glu Cys Leu Val Cys Arg Glu Pro Tyr Ser 
        35                  40                  45              


Cys Pro Arg Leu Pro Lys Leu Leu Ala Cys Gln His Ala Phe Cys Ala 
    50                  55                  60                  


Ile Cys Leu Lys Leu Leu Leu Cys Val Gln Asp Asn Thr Trp Ser Ile 
65                  70                  75                  80  


Thr Cys Pro Leu Cys Arg Lys Val Thr Ala Val Pro Gly Gly Leu Ile 
                85                  90                  95      


Cys Ser Leu Arg Asp His Glu Ala Val Val Gly Gln Leu Ala Gln Pro 
            100                 105                 110         


Cys Thr Glu Val Ser Leu Cys Pro Gln Gly Leu Val Asp Pro Ala Asp 
        115                 120                 125             


Leu Ala Ala Gly His Pro Ser Leu Val Gly Glu Asp Gly Gln Asp Glu 
    130                 135                 140                 


Val Ser Ala Asn His Val Ala Ala Arg Arg Leu Ala Ala His Leu Leu 
145                 150                 155                 160 


Leu Leu Ala Leu Leu Ile Ile Leu Ile Gly Pro Phe Ile Tyr Pro Gly 
                165                 170                 175     


Val Leu Arg Trp Val Leu Thr Phe Ile Ile Ala Leu Ala Leu Leu Met 
            180                 185                 190         


Ser Thr Leu Phe Cys Cys Leu Pro Ser Thr Arg Gly Ser Cys Trp Pro 
        195                 200                 205             


Ser Ser Arg Thr Leu Phe Cys Arg Glu Gln Lys His Ser His Ile Ser 
    210                 215                 220                 


Ser Ile Ala 
225         


<210>  4556
<211>  685
<212>  PRT
<213>  Homo sapiens

<400>  4556

Met Ala Ala Ala Ser Arg Ser Ala Ser Gly Trp Ala Leu Leu Leu Leu 
1               5                   10                  15      


Val Ala Leu Trp Gln Gln Arg Ala Ala Gly Ser Gly Val Phe Gln Leu 
            20                  25                  30          


Gln Leu Gln Glu Phe Ile Asn Glu Arg Gly Val Leu Ala Ser Gly Arg 
        35                  40                  45              


Pro Cys Glu Pro Gly Cys Arg Thr Phe Phe Arg Val Cys Leu Lys His 
    50                  55                  60                  


Phe Gln Ala Val Val Ser Pro Gly Pro Cys Thr Phe Gly Thr Val Ser 
65                  70                  75                  80  


Thr Pro Val Leu Gly Thr Asn Ser Phe Ala Val Arg Asp Asp Ser Ser 
                85                  90                  95      


Gly Gly Gly Arg Asn Pro Leu Gln Leu Pro Phe Asn Phe Thr Trp Pro 
            100                 105                 110         


Gly Thr Phe Ser Leu Ile Ile Glu Ala Trp His Ala Pro Gly Asp Asp 
        115                 120                 125             


Leu Arg Pro Glu Ala Leu Pro Pro Asp Ala Leu Ile Ser Lys Ile Ala 
    130                 135                 140                 


Ile Gln Gly Ser Leu Ala Val Gly Gln Asn Trp Leu Leu Asp Glu Gln 
145                 150                 155                 160 


Thr Ser Thr Leu Thr Arg Leu Arg Tyr Ser Tyr Arg Val Ile Cys Ser 
                165                 170                 175     


Asp Asn Tyr Tyr Gly Asp Asn Cys Ser Arg Leu Cys Lys Lys Arg Asn 
            180                 185                 190         


Asp His Phe Gly His Tyr Val Cys Gln Pro Asp Gly Asn Leu Ser Cys 
        195                 200                 205             


Leu Pro Gly Trp Thr Gly Glu Tyr Cys Gln Gln Pro Ile Cys Leu Ser 
    210                 215                 220                 


Gly Cys His Glu Gln Asn Gly Tyr Cys Ser Lys Pro Ala Glu Cys Leu 
225                 230                 235                 240 


Cys Arg Pro Gly Trp Gln Gly Arg Leu Cys Asn Glu Cys Ile Pro His 
                245                 250                 255     


Asn Gly Cys Arg His Gly Thr Cys Ser Thr Pro Trp Gln Cys Thr Cys 
            260                 265                 270         


Asp Glu Gly Trp Gly Gly Leu Phe Cys Asp Gln Asp Leu Asn Tyr Cys 
        275                 280                 285             


Thr His His Ser Pro Cys Lys Asn Gly Ala Thr Cys Ser Asn Ser Gly 
    290                 295                 300                 


Gln Arg Ser Tyr Thr Cys Thr Cys Arg Pro Gly Tyr Thr Gly Val Asp 
305                 310                 315                 320 


Cys Glu Leu Glu Leu Ser Glu Cys Asp Ser Asn Pro Cys Arg Asn Gly 
                325                 330                 335     


Gly Ser Cys Lys Asp Gln Glu Asp Gly Tyr His Cys Leu Cys Pro Pro 
            340                 345                 350         


Gly Tyr Tyr Gly Leu His Cys Glu His Ser Thr Leu Ser Cys Ala Asp 
        355                 360                 365             


Ser Pro Cys Phe Asn Gly Gly Ser Cys Arg Glu Arg Asn Gln Gly Ala 
    370                 375                 380                 


Asn Tyr Ala Cys Glu Cys Pro Pro Asn Phe Thr Gly Ser Asn Cys Glu 
385                 390                 395                 400 


Lys Lys Val Asp Arg Cys Thr Ser Asn Pro Cys Ala Asn Gly Gly Gln 
                405                 410                 415     


Cys Leu Asn Arg Gly Pro Ser Arg Met Cys Arg Cys Arg Pro Gly Phe 
            420                 425                 430         


Thr Gly Thr Tyr Cys Glu Leu His Val Ser Asp Cys Ala Arg Asn Pro 
        435                 440                 445             


Cys Ala His Gly Gly Thr Cys His Asp Leu Glu Asn Gly Leu Met Cys 
    450                 455                 460                 


Thr Cys Pro Ala Gly Phe Ser Gly Arg Arg Cys Glu Val Arg Thr Ser 
465                 470                 475                 480 


Ile Asp Ala Cys Ala Ser Ser Pro Cys Phe Asn Arg Ala Thr Cys Tyr 
                485                 490                 495     


Thr Asp Leu Ser Thr Asp Thr Phe Val Cys Asn Cys Pro Tyr Gly Phe 
            500                 505                 510         


Val Gly Ser Arg Cys Glu Phe Pro Val Gly Leu Pro Pro Ser Phe Pro 
        515                 520                 525             


Trp Val Ala Val Ser Leu Gly Val Gly Leu Ala Val Leu Leu Val Leu 
    530                 535                 540                 


Leu Gly Met Val Ala Val Ala Val Arg Gln Leu Arg Leu Arg Arg Pro 
545                 550                 555                 560 


Asp Asp Gly Ser Arg Glu Ala Met Asn Asn Leu Ser Asp Phe Gln Lys 
                565                 570                 575     


Asp Asn Leu Ile Pro Ala Ala Gln Leu Lys Asn Thr Asn Gln Lys Lys 
            580                 585                 590         


Glu Leu Glu Val Asp Cys Gly Leu Asp Lys Ser Asn Cys Gly Lys Gln 
        595                 600                 605             


Gln Asn His Thr Leu Asp Tyr Asn Leu Ala Pro Gly Pro Leu Gly Arg 
    610                 615                 620                 


Gly Thr Met Pro Gly Lys Phe Pro His Ser Asp Lys Ser Leu Gly Glu 
625                 630                 635                 640 


Lys Ala Pro Leu Arg Leu His Ser Glu Lys Pro Glu Cys Arg Ile Ser 
                645                 650                 655     


Ala Ile Cys Ser Pro Arg Asp Ser Met Tyr Gln Ser Val Cys Leu Ile 
            660                 665                 670         


Ser Glu Glu Arg Asn Glu Cys Val Ile Ala Thr Glu Val 
        675                 680                 685 


<210>  4557
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  4557

Met Ala Arg Ala Gly Trp Thr Ser Pro Val Pro Leu Cys Val Cys Leu 
1               5                   10                  15      


Leu Leu Thr Cys Gly Phe Ala Glu Ala Gly Lys Leu Leu Val Val Pro 
            20                  25                  30          


Met Asp Gly Ser His Trp Phe Thr Met Gln Ser Val Val Glu Lys Leu 
        35                  40                  45              


Ile Leu Arg Gly His Glu Val Val Val Val Met Pro Glu Val Ser Trp 
    50                  55                  60                  


Gln Leu Glu Arg Ser Leu Asn Cys Thr Val Lys Thr Tyr Ser Thr Ser 
65                  70                  75                  80  


Tyr Thr Leu Glu Asp Gln Asn Arg Glu Phe Met Val Phe Ala His Ala 
                85                  90                  95      


Gln Trp Lys Ala Gln Ala Gln Ser Ile Phe Ser Leu Leu Met Ser Ser 
            100                 105                 110         


Ser Ser Gly Phe Leu Asp Leu Phe Phe Ser His Cys Arg Ser Leu Phe 
        115                 120                 125             


Asn Asp Arg Lys Leu Val Glu Tyr Leu Lys Glu Ser Ser Phe Asp Ala 
    130                 135                 140                 


Val Phe Leu Asp Pro Phe Asp Thr Cys Gly Leu Ile Val Ala Lys Tyr 
145                 150                 155                 160 


Phe Ser Leu Pro Ser Val Val Phe Thr Arg Gly Ile Phe Cys His His 
                165                 170                 175     


Leu Glu Glu Gly Ala Gln Cys Pro Ala Pro Leu Ser Tyr Val Pro Asn 
            180                 185                 190         


Asp Leu Leu Gly Phe Ser Asp Ala Met Thr Phe Lys Glu Arg Val Trp 
        195                 200                 205             


Asn His Ile Val His Leu Glu Asp His Leu Phe Cys Gln Tyr Leu Phe 
    210                 215                 220                 


Arg Asn Ala Leu Glu Ile Ala Ser Glu Ile Leu Gln Thr Pro Val Thr 
225                 230                 235                 240 


Ala Tyr Asp Leu Tyr Ser His Thr Ser Ile Trp Leu Leu Arg Thr Asp 
                245                 250                 255     


Phe Val Leu Asp Tyr Pro Lys Pro Val Met Pro Asn Met Ile Phe Ile 
            260                 265                 270         


Gly Gly Ile Asn Cys His Gln Gly Lys Pro Leu Pro Met Glu Phe Glu 
        275                 280                 285             


Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val Val Phe Ser Leu 
    290                 295                 300                 


Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala Met Ala Ile Ala 
305                 310                 315                 320 


Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp Arg Tyr Thr Gly 
                325                 330                 335     


Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu Val Lys Trp Leu 
            340                 345                 350         


Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg Ala Phe Ile Thr 
        355                 360                 365             


His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys Asn Gly Val Pro 
    370                 375                 380                 


Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp Asn Ala Lys Arg 
385                 390                 395                 400 


Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val Leu Glu Met Thr 
                405                 410                 415     


Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile Asn Asp Lys Ser 
            420                 425                 430         


Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His Lys Asp Arg Pro 
        435                 440                 445             


Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu Phe Val Met Arg 
    450                 455                 460                 


His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His Asp Leu Thr Trp 
465                 470                 475                 480 


Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu Leu Ala Val Val 
                485                 490                 495     


Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala Tyr Gly Tyr Arg 
            500                 505                 510         


Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala His Lys Ser Lys 
        515                 520                 525             


Thr His 
    530 


<210>  4558
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  4558

Met Ala Arg Thr Gly Trp Thr Ser Pro Ile Pro Leu Cys Val Ser Leu 
1               5                   10                  15      


Leu Leu Thr Cys Gly Phe Ala Glu Ala Gly Lys Leu Leu Val Val Pro 
            20                  25                  30          


Met Asp Gly Ser His Trp Phe Thr Met Gln Ser Val Val Glu Lys Leu 
        35                  40                  45              


Ile Leu Arg Gly His Glu Val Val Val Val Met Pro Glu Val Ser Trp 
    50                  55                  60                  


Gln Leu Gly Lys Ser Leu Asn Cys Thr Val Lys Thr Tyr Ser Thr Ser 
65                  70                  75                  80  


Tyr Thr Leu Glu Asp Leu Asp Arg Glu Phe Met Asp Phe Ala Asp Ala 
                85                  90                  95      


Gln Trp Lys Ala Gln Val Arg Ser Leu Phe Ser Leu Phe Leu Ser Ser 
            100                 105                 110         


Ser Asn Gly Phe Phe Asn Leu Phe Phe Ser His Cys Arg Ser Leu Phe 
        115                 120                 125             


Asn Asp Arg Lys Leu Val Glu Tyr Leu Lys Glu Ser Ser Phe Asp Ala 
    130                 135                 140                 


Val Phe Leu Asp Pro Phe Asp Ala Cys Gly Leu Ile Val Ala Lys Tyr 
145                 150                 155                 160 


Phe Ser Leu Pro Ser Val Val Phe Ala Arg Gly Ile Ala Cys His Tyr 
                165                 170                 175     


Leu Glu Glu Gly Ala Gln Cys Pro Ala Pro Leu Ser Tyr Val Pro Arg 
            180                 185                 190         


Ile Leu Leu Gly Phe Ser Asp Ala Met Thr Phe Lys Glu Arg Val Arg 
        195                 200                 205             


Asn His Ile Met His Leu Glu Glu His Leu Phe Cys Gln Tyr Phe Ser 
    210                 215                 220                 


Lys Asn Ala Leu Glu Ile Ala Ser Glu Ile Leu Gln Thr Pro Val Thr 
225                 230                 235                 240 


Ala Tyr Asp Leu Tyr Ser His Thr Ser Ile Trp Leu Leu Arg Thr Asp 
                245                 250                 255     


Phe Val Leu Asp Tyr Pro Lys Pro Val Met Pro Asn Met Ile Phe Ile 
            260                 265                 270         


Gly Gly Ile Asn Cys His Gln Gly Lys Pro Leu Pro Met Glu Phe Glu 
        275                 280                 285             


Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val Val Phe Ser Leu 
    290                 295                 300                 


Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala Met Ala Ile Ala 
305                 310                 315                 320 


Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp Arg Tyr Thr Gly 
                325                 330                 335     


Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu Val Lys Trp Leu 
            340                 345                 350         


Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg Ala Phe Ile Thr 
        355                 360                 365             


His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys Asn Gly Val Pro 
    370                 375                 380                 


Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp Asn Ala Lys Arg 
385                 390                 395                 400 


Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val Leu Glu Met Thr 
                405                 410                 415     


Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile Asn Asp Lys Ser 
            420                 425                 430         


Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His Lys Asp Arg Pro 
        435                 440                 445             


Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu Phe Val Met Arg 
    450                 455                 460                 


His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His Asp Leu Thr Trp 
465                 470                 475                 480 


Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu Leu Ala Val Val 
                485                 490                 495     


Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala Tyr Gly Tyr Arg 
            500                 505                 510         


Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala His Lys Ser Lys 
        515                 520                 525             


Thr His 
    530 


<210>  4559
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  4559

Met Ala Arg Ala Gly Trp Thr Gly Leu Leu Pro Leu Tyr Val Cys Leu 
1               5                   10                  15      


Leu Leu Thr Cys Gly Phe Ala Lys Ala Gly Lys Leu Leu Val Val Pro 
            20                  25                  30          


Met Asp Gly Ser His Trp Phe Thr Met Gln Ser Val Val Glu Lys Leu 
        35                  40                  45              


Ile Leu Arg Gly His Glu Val Val Val Val Met Pro Glu Val Ser Trp 
    50                  55                  60                  


Gln Leu Gly Arg Ser Leu Asn Cys Thr Val Lys Thr Tyr Ser Thr Ser 
65                  70                  75                  80  


Tyr Thr Leu Glu Asp Gln Asp Arg Glu Phe Met Val Phe Ala Asp Ala 
                85                  90                  95      


Arg Trp Thr Ala Pro Leu Arg Ser Ala Phe Ser Leu Leu Thr Ser Ser 
            100                 105                 110         


Ser Asn Gly Ile Phe Asp Leu Phe Phe Ser Asn Cys Arg Ser Leu Phe 
        115                 120                 125             


Asn Asp Arg Lys Leu Val Glu Tyr Leu Lys Glu Ser Cys Phe Asp Ala 
    130                 135                 140                 


Val Phe Leu Asp Pro Phe Asp Ala Cys Gly Leu Ile Val Ala Lys Tyr 
145                 150                 155                 160 


Phe Ser Leu Pro Ser Val Val Phe Ala Arg Gly Ile Phe Cys His Tyr 
                165                 170                 175     


Leu Glu Glu Gly Ala Gln Cys Pro Ala Pro Leu Ser Tyr Val Pro Arg 
            180                 185                 190         


Leu Leu Leu Gly Phe Ser Asp Ala Met Thr Phe Lys Glu Arg Val Trp 
        195                 200                 205             


Asn His Ile Met His Leu Glu Glu His Leu Phe Cys Pro Tyr Phe Phe 
    210                 215                 220                 


Lys Asn Val Leu Glu Ile Ala Ser Glu Ile Leu Gln Thr Pro Val Thr 
225                 230                 235                 240 


Ala Tyr Asp Leu Tyr Ser His Thr Ser Ile Trp Leu Leu Arg Thr Asp 
                245                 250                 255     


Phe Val Leu Glu Tyr Pro Lys Pro Val Met Pro Asn Met Ile Phe Ile 
            260                 265                 270         


Gly Gly Ile Asn Cys His Gln Gly Lys Pro Val Pro Met Glu Phe Glu 
        275                 280                 285             


Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val Val Phe Ser Leu 
    290                 295                 300                 


Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala Met Ala Ile Ala 
305                 310                 315                 320 


Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp Arg Tyr Thr Gly 
                325                 330                 335     


Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu Val Lys Trp Leu 
            340                 345                 350         


Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg Ala Phe Ile Thr 
        355                 360                 365             


His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys Asn Gly Val Pro 
    370                 375                 380                 


Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp Asn Ala Lys Arg 
385                 390                 395                 400 


Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val Leu Glu Met Thr 
                405                 410                 415     


Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile Asn Asp Lys Ser 
            420                 425                 430         


Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His Lys Asp Arg Pro 
        435                 440                 445             


Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu Phe Val Met Arg 
    450                 455                 460                 


His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His Asp Leu Thr Trp 
465                 470                 475                 480 


Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu Leu Ala Val Val 
                485                 490                 495     


Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala Tyr Gly Tyr Arg 
            500                 505                 510         


Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala His Lys Ser Lys 
        515                 520                 525             


Thr His 
    530 


<210>  4560
<211>  534
<212>  PRT
<213>  Homo sapiens

<400>  4560

Met Ala Thr Gly Leu Gln Val Pro Leu Pro Gln Leu Ala Thr Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Val Gln Pro Trp Ala Glu Ser Gly Lys Val Leu 
            20                  25                  30          


Val Val Pro Thr Asp Gly Ser His Trp Leu Ser Met Arg Glu Ala Leu 
        35                  40                  45              


Arg Asp Leu His Ala Arg Gly His Gln Val Val Val Leu Thr Leu Glu 
    50                  55                  60                  


Val Asn Met Tyr Ile Lys Glu Glu Asn Phe Phe Thr Leu Thr Thr Tyr 
65                  70                  75                  80  


Ala Ile Ser Trp Thr Gln Asp Glu Phe Asp Arg Leu Leu Leu Gly His 
                85                  90                  95      


Thr Gln Ser Phe Phe Glu Thr Glu His Leu Leu Met Lys Phe Ser Arg 
            100                 105                 110         


Arg Met Ala Ile Met Asn Asn Met Ser Leu Ile Ile His Arg Ser Cys 
        115                 120                 125             


Val Glu Leu Leu His Asn Glu Ala Leu Ile Arg His Leu His Ala Thr 
    130                 135                 140                 


Ser Phe Asp Val Val Leu Thr Asp Pro Phe His Leu Cys Ala Ala Val 
145                 150                 155                 160 


Leu Ala Lys Tyr Leu Ser Ile Pro Ala Val Phe Phe Leu Arg Asn Ile 
                165                 170                 175     


Pro Cys Asp Leu Asp Phe Lys Gly Thr Gln Cys Pro Asn Pro Ser Ser 
            180                 185                 190         


Tyr Ile Pro Arg Leu Leu Thr Thr Asn Ser Asp His Met Thr Phe Leu 
        195                 200                 205             


Gln Arg Val Lys Asn Met Leu Tyr Pro Leu Ala Leu Ser Tyr Leu Cys 
    210                 215                 220                 


His Ala Val Ser Ala Pro Tyr Ala Ser Leu Ala Ser Glu Leu Phe Gln 
225                 230                 235                 240 


Arg Glu Val Ser Val Val Asp Leu Val Ser His Ala Ser Val Trp Leu 
                245                 250                 255     


Phe Arg Gly Asp Phe Val Met Asp Tyr Pro Arg Pro Ile Met Pro Asn 
            260                 265                 270         


Met Val Phe Ile Gly Gly Ile Asn Cys Ala Asn Gly Lys Pro Leu Ser 
        275                 280                 285             


Gln Glu Phe Glu Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val 
    290                 295                 300                 


Val Phe Ser Leu Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala 
305                 310                 315                 320 


Met Ala Ile Ala Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp 
                325                 330                 335     


Arg Tyr Thr Gly Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu 
            340                 345                 350         


Val Lys Trp Leu Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg 
        355                 360                 365             


Ala Phe Ile Thr His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys 
    370                 375                 380                 


Asn Gly Val Pro Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp 
385                 390                 395                 400 


Asn Ala Lys Arg Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val 
                405                 410                 415     


Leu Glu Met Thr Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile 
            420                 425                 430         


Asn Asp Lys Ser Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His 
        435                 440                 445             


Lys Asp Arg Pro Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu 
    450                 455                 460                 


Phe Val Met Arg His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His 
465                 470                 475                 480 


Asp Leu Thr Trp Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu 
                485                 490                 495     


Leu Ala Val Val Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala 
            500                 505                 510         


Tyr Gly Tyr Arg Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala 
        515                 520                 525             


His Lys Ser Lys Thr His 
    530                 


<210>  4561
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  4561

Met Ala Arg Arg Arg Ser Gln Arg Val Cys Ala Ser Gly Pro Ser Met 
1               5                   10                  15      


Leu Asn Ser Ala Arg Gly Ala Pro Glu Leu Leu Arg Gly Thr Ala Thr 
            20                  25                  30          


Asn Ala Glu Val Ser Ala Ala Ala Ala Gly Ala Thr Gly Ser Glu Glu 
        35                  40                  45              


Leu Pro Pro Gly Asp Arg Gly Cys Arg Asn Gly Gly Gly Arg Gly Pro 
    50                  55                  60                  


Ala Ala Thr Thr Ser Ser Thr Gly Val Ala Val Gly Ala Glu His Gly 
65                  70                  75                  80  


Glu Asp Ser Leu Ser Arg Lys Pro Asp Pro Glu Pro Gly Arg Met Asp 
                85                  90                  95      


His His Gln Pro Gly Thr Gly Arg Tyr Gln Val Leu Leu Asn Glu Glu 
            100                 105                 110         


Asp Asn Ser Glu Ser Ser Ala Ile Glu Gln Pro Pro Thr Ser Asn Pro 
        115                 120                 125             


Ala Pro Gln Ile Val Gln Ala Ala Ser Ser Ala Pro Ala Leu Glu Thr 
    130                 135                 140                 


Asp Ser Ser Pro Pro Pro Tyr Ser Ser Ile Thr Val Glu Val Pro Thr 
145                 150                 155                 160 


Thr Ser Asp Thr Glu Val Tyr Gly Glu Phe Tyr Pro Val Pro Pro Pro 
                165                 170                 175     


Tyr Ser Val Ala Thr Ser Leu Pro Thr Tyr Asp Glu Ala Glu Lys Ala 
            180                 185                 190         


Lys Ala Ala Ala Met Ala Ala Ala Ala Ala Glu Thr Ser Gln Arg Ile 
        195                 200                 205             


Gln Glu Glu Glu Cys Pro Pro Arg Asp Asp Phe Ser Asp Ala Asp Gln 
    210                 215                 220                 


Leu Arg Val Gly Asn Asp Gly Ile Phe Met Leu Ala Phe Phe Met Ala 
225                 230                 235                 240 


Phe Ile Phe Asn Trp Leu Gly Phe Cys Leu Ser Phe Cys Ile Thr Asn 
                245                 250                 255     


Thr Ile Ala Gly Arg Tyr Gly Ala Ile Cys Gly Phe Gly Leu Ser Leu 
            260                 265                 270         


Ile Lys Trp Ile Leu Ile Val Arg Phe Ser Asp Tyr Phe Thr Gly Tyr 
        275                 280                 285             


Phe Asn Gly Gln Tyr Trp Leu Trp Trp Ile Phe Leu Val Leu Gly Leu 
    290                 295                 300                 


Leu Leu Phe Phe Arg Gly Phe Val Asn Tyr Leu Lys Val Arg Asn Met 
305                 310                 315                 320 


Ser Glu Ser Met Ala Ala Ala His Arg Thr Arg Tyr Phe Phe Leu Leu 
                325                 330                 335     


<210>  4562
<211>  540
<212>  PRT
<213>  Homo sapiens

<400>  4562

Met Ala Ala Gly Gly Ser Ala Pro Glu Pro Arg Val Leu Val Cys Leu 
1               5                   10                  15      


Gly Ala Leu Leu Ala Gly Trp Val Ala Val Gly Leu Glu Ala Val Val 
            20                  25                  30          


Ile Gly Glu Val His Glu Asn Val Thr Leu His Cys Gly Asn Ile Ser 
        35                  40                  45              


Gly Leu Arg Gly Gln Val Thr Trp Tyr Arg Asn Asn Ser Glu Pro Val 
    50                  55                  60                  


Phe Leu Leu Ser Ser Asn Ser Ser Leu Arg Pro Ala Glu Pro Arg Phe 
65                  70                  75                  80  


Ser Leu Val Asp Ala Thr Ser Leu His Ile Glu Ser Leu Ser Leu Gly 
                85                  90                  95      


Asp Glu Gly Ile Tyr Thr Cys Gln Glu Ile Leu Asn Val Thr Gln Trp 
            100                 105                 110         


Phe Gln Val Trp Leu Gln Val Ala Ser Gly Pro Tyr Gln Ile Glu Val 
        115                 120                 125             


His Ile Val Ala Thr Gly Thr Leu Pro Asn Gly Thr Leu Tyr Ala Ala 
    130                 135                 140                 


Arg Gly Ser Gln Val Asp Phe Ser Cys Asn Ser Ser Ser Arg Pro Pro 
145                 150                 155                 160 


Pro Val Val Glu Trp Trp Phe Gln Ala Leu Asn Ser Ser Ser Glu Ser 
                165                 170                 175     


Phe Gly His Asn Leu Thr Val Asn Phe Phe Ser Leu Leu Leu Ile Ser 
            180                 185                 190         


Pro Asn Leu Gln Gly Asn Tyr Thr Cys Leu Ala Leu Asn Gln Leu Ser 
        195                 200                 205             


Lys Arg His Arg Lys Val Thr Thr Glu Leu Leu Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Pro Ser Ala Pro Gln Cys Trp Ala Gln Met Ala Ser Gly Ser Phe Met 
225                 230                 235                 240 


Leu Gln Leu Thr Cys Arg Trp Asp Gly Gly Tyr Pro Asp Pro Asp Phe 
                245                 250                 255     


Leu Trp Ile Glu Glu Pro Gly Gly Val Ile Val Gly Lys Ser Lys Leu 
            260                 265                 270         


Gly Val Glu Met Leu Ser Glu Ser Gln Leu Ser Asp Gly Lys Lys Phe 
        275                 280                 285             


Lys Cys Val Thr Ser His Ile Val Gly Pro Glu Ser Gly Ala Ser Cys 
    290                 295                 300                 


Met Val Gln Ile Arg Gly Pro Ser Leu Leu Ser Glu Pro Met Lys Thr 
305                 310                 315                 320 


Cys Phe Thr Gly Gly Asn Val Thr Leu Thr Cys Gln Val Ser Gly Ala 
                325                 330                 335     


Tyr Pro Pro Ala Lys Ile Leu Trp Leu Arg Asn Leu Thr Gln Pro Glu 
            340                 345                 350         


Val Ile Ile Gln Pro Ser Ser Arg His Leu Ile Thr Gln Asp Gly Gln 
        355                 360                 365             


Asn Ser Thr Leu Thr Ile His Asn Cys Ser Gln Asp Leu Asp Glu Gly 
    370                 375                 380                 


Tyr Tyr Ile Cys Arg Ala Asp Ser Pro Val Gly Val Arg Glu Met Glu 
385                 390                 395                 400 


Ile Trp Leu Ser Val Lys Glu Pro Leu Asn Ile Gly Gly Ile Val Gly 
                405                 410                 415     


Thr Ile Val Ser Leu Leu Leu Leu Gly Leu Ala Ile Ile Ser Gly Leu 
            420                 425                 430         


Leu Leu His Tyr Ser Pro Val Phe Cys Trp Lys Val Gly Asn Thr Ser 
        435                 440                 445             


Arg Gly Gln Asn Met Asp Asp Val Met Val Leu Val Asp Ser Glu Glu 
    450                 455                 460                 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Ala Ala Val Gly Glu 
465                 470                 475                 480 


Gln Glu Gly Ala Arg Glu Arg Glu Glu Leu Pro Lys Glu Ile Pro Lys 
                485                 490                 495     


Gln Asp His Ile His Arg Val Thr Ala Leu Val Asn Gly Asn Ile Glu 
            500                 505                 510         


Gln Met Gly Asn Gly Phe Gln Asp Leu Gln Asp Asp Ser Ser Glu Glu 
        515                 520                 525             


Gln Ser Asp Ile Val Gln Glu Glu Asp Arg Pro Val 
    530                 535                 540 


<210>  4563
<211>  534
<212>  PRT
<213>  Homo sapiens

<400>  4563

Met Ala Thr Gly Leu Gln Val Pro Leu Pro Trp Leu Ala Thr Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Val Gln Pro Trp Ala Glu Ser Gly Lys Val Leu 
            20                  25                  30          


Val Val Pro Ile Asp Gly Ser His Trp Leu Ser Met Arg Glu Val Leu 
        35                  40                  45              


Arg Glu Leu His Ala Arg Gly His Gln Ala Val Val Leu Thr Pro Glu 
    50                  55                  60                  


Val Asn Met His Ile Lys Glu Glu Asn Phe Phe Thr Leu Thr Thr Tyr 
65                  70                  75                  80  


Ala Ile Ser Trp Thr Gln Asp Glu Phe Asp Arg His Val Leu Gly His 
                85                  90                  95      


Thr Gln Leu Tyr Phe Glu Thr Glu His Phe Leu Lys Lys Phe Phe Arg 
            100                 105                 110         


Ser Met Ala Met Leu Asn Asn Met Ser Leu Val Tyr His Arg Ser Cys 
        115                 120                 125             


Val Glu Leu Leu His Asn Glu Ala Leu Ile Arg His Leu Asn Ala Thr 
    130                 135                 140                 


Ser Phe Asp Val Val Leu Thr Asp Pro Val Asn Leu Cys Ala Ala Val 
145                 150                 155                 160 


Leu Ala Lys Tyr Leu Ser Ile Pro Thr Val Phe Phe Leu Arg Asn Ile 
                165                 170                 175     


Pro Cys Asp Leu Asp Phe Lys Gly Thr Gln Cys Pro Asn Pro Ser Ser 
            180                 185                 190         


Tyr Ile Pro Arg Leu Leu Thr Thr Asn Ser Asp His Met Thr Phe Met 
        195                 200                 205             


Gln Arg Val Lys Asn Met Leu Tyr Pro Leu Ala Leu Ser Tyr Ile Cys 
    210                 215                 220                 


His Ala Phe Ser Ala Pro Tyr Ala Ser Leu Ala Ser Glu Leu Phe Gln 
225                 230                 235                 240 


Arg Glu Val Ser Val Val Asp Ile Leu Ser His Ala Ser Val Trp Leu 
                245                 250                 255     


Phe Arg Gly Asp Phe Val Met Asp Tyr Pro Arg Pro Ile Met Pro Asn 
            260                 265                 270         


Met Val Phe Ile Gly Gly Ile Asn Cys Ala Asn Arg Lys Pro Leu Ser 
        275                 280                 285             


Gln Glu Phe Glu Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val 
    290                 295                 300                 


Val Phe Ser Leu Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala 
305                 310                 315                 320 


Met Ala Ile Ala Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp 
                325                 330                 335     


Arg Tyr Thr Gly Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu 
            340                 345                 350         


Val Lys Trp Leu Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg 
        355                 360                 365             


Ala Phe Ile Thr His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys 
    370                 375                 380                 


Asn Gly Val Pro Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp 
385                 390                 395                 400 


Asn Ala Lys Arg Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val 
                405                 410                 415     


Leu Glu Met Thr Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile 
            420                 425                 430         


Asn Asp Lys Ser Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His 
        435                 440                 445             


Lys Asp Arg Pro Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu 
    450                 455                 460                 


Phe Val Met Arg His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His 
465                 470                 475                 480 


Asp Leu Thr Trp Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu 
                485                 490                 495     


Leu Ala Val Val Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala 
            500                 505                 510         


Tyr Gly Tyr Arg Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala 
        515                 520                 525             


His Lys Ser Lys Thr His 
    530                 


<210>  4564
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  4564

Met Leu Ala Leu Arg Val Ala Arg Gly Ser Trp Gly Ala Leu Arg Gly 
1               5                   10                  15      


Ala Ala Trp Ala Pro Gly Thr Arg Pro Ser Lys Arg Arg Ala Cys Trp 
            20                  25                  30          


Ala Leu Leu Pro Pro Val Pro Cys Cys Leu Gly Cys Leu Ala Glu Arg 
        35                  40                  45              


Trp Arg Leu Arg Pro Ala Ala Leu Gly Leu Arg Leu Pro Gly Ile Gly 
    50                  55                  60                  


Gln Arg Asn His Cys Ser Gly Ala Gly Lys Ala Ala Pro Arg Pro Ala 
65                  70                  75                  80  


Ala Gly Ala Gly Ala Ala Ala Glu Ala Pro Gly Gly Gln Trp Gly Pro 
                85                  90                  95      


Ala Ser Thr Pro Ser Leu Tyr Glu Asn Pro Trp Thr Ile Pro Asn Met 
            100                 105                 110         


Leu Ser Met Thr Arg Ile Gly Leu Ala Pro Val Leu Gly Tyr Leu Ile 
        115                 120                 125             


Ile Glu Glu Asp Phe Asn Ile Ala Leu Gly Val Phe Ala Leu Ala Gly 
    130                 135                 140                 


Leu Thr Asp Leu Leu Asp Gly Phe Ile Ala Arg Asn Trp Ala Asn Gln 
145                 150                 155                 160 


Arg Ser Ala Leu Gly Ser Ala Leu Asp Pro Leu Ala Asp Lys Ile Leu 
                165                 170                 175     


Ile Ser Ile Leu Tyr Val Ser Leu Thr Tyr Ala Asp Leu Ile Pro Val 
            180                 185                 190         


Pro Leu Thr Tyr Met Ile Ile Ser Arg Asp Val Met Leu Ile Ala Ala 
        195                 200                 205             


Val Phe Tyr Val Arg Tyr Arg Thr Leu Pro Thr Pro Arg Thr Leu Ala 
    210                 215                 220                 


Lys Tyr Phe Asn Pro Cys Tyr Ala Thr Ala Arg Leu Lys Pro Thr Phe 
225                 230                 235                 240 


Ile Ser Lys Val Asn Thr Ala Val Gln Leu Ile Leu Val Ala Ala Ser 
                245                 250                 255     


Leu Ala Ala Pro Val Phe Asn Tyr Ala Asp Ser Ile Tyr Leu Gln Ile 
            260                 265                 270         


Leu Trp Cys Phe Thr Ala Phe Thr Thr Ala Ala Ser Ala Tyr Ser Tyr 
        275                 280                 285             


Tyr His Tyr Gly Arg Lys Thr Val Gln Val Ile Lys Asp 
    290                 295                 300     


<210>  4565
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  4565

Met Ala Ala Ser Cys Leu Val Leu Leu Ala Leu Cys Leu Leu Leu Pro 
1               5                   10                  15      


Leu Leu Leu Leu Gly Gly Trp Lys Arg Trp Arg Arg Gly Arg Ala Ala 
            20                  25                  30          


Arg His Val Val Ala Val Val Leu Gly Asp Val Gly Arg Ser Pro Arg 
        35                  40                  45              


Met Gln Tyr His Ala Leu Ser Leu Ala Met His Gly Phe Ser Val Thr 
    50                  55                  60                  


Leu Leu Gly Phe Cys Asn Ser Lys Pro His Asp Glu Leu Leu Gln Asn 
65                  70                  75                  80  


Asn Arg Ile Gln Ile Val Gly Leu Thr Glu Leu Gln Ser Leu Ala Val 
                85                  90                  95      


Gly Pro Arg Val Phe Gln Tyr Gly Val Lys Val Val Leu Gln Ala Met 
            100                 105                 110         


Tyr Leu Leu Trp Lys Leu Met Trp Arg Glu Pro Gly Ala Tyr Ile Phe 
        115                 120                 125             


Leu Gln Asn Pro Pro Gly Leu Pro Ser Ile Ala Val Cys Trp Phe Val 
    130                 135                 140                 


Gly Cys Leu Cys Gly Ser Lys Leu Val Ile Asp Trp His Asn Tyr Gly 
145                 150                 155                 160 


Tyr Ser Ile Met Gly Leu Val His Gly Pro Asn His Pro Leu Val Leu 
                165                 170                 175     


Leu Ala Lys Trp Tyr Glu Lys Phe Phe Gly Arg Leu Ser His Leu Asn 
            180                 185                 190         


Leu Cys Val Thr Asn Ala Met Arg Glu Asp Leu Ala Asp Asn Trp His 
        195                 200                 205             


Ile Arg Ala Val Thr Val Tyr Asp Lys Pro Ala Ser Phe Phe Lys Glu 
    210                 215                 220                 


Thr Pro Leu Asp Leu Gln His Arg Leu Phe Met Lys Leu Gly Ser Met 
225                 230                 235                 240 


His Ser Pro Phe Arg Ala Arg Ser Glu Pro Glu Asp Pro Val Thr Glu 
                245                 250                 255     


Arg Ser Ala Phe Thr Glu Arg Asp Ala Gly Ser Gly Leu Val Thr Arg 
            260                 265                 270         


Leu Arg Glu Arg Pro Ala Leu Leu Val Ser Ser Thr Ser Trp Thr Glu 
        275                 280                 285             


Asp Glu Asp Phe Ser Ile Leu Leu Ala Ala Leu Glu Lys Phe Glu Gln 
    290                 295                 300                 


Leu Thr Leu Asp Gly His Asn Leu Pro Ser Leu Val Cys Val Ile Thr 
305                 310                 315                 320 


Gly Lys Gly Pro Leu Arg Glu Tyr Tyr Ser Arg Leu Ile His Gln Lys 
                325                 330                 335     


His Phe Gln His Ile Gln Val Cys Thr Pro Trp Leu Glu Ala Glu Asp 
            340                 345                 350         


Tyr Pro Leu Leu Leu Gly Ser Ala Asp Leu Gly Val Cys Leu His Thr 
        355                 360                 365             


Ser Ser Ser Gly Leu Asp Leu Pro Met Lys Val Val Asp Met Phe Gly 
    370                 375                 380                 


Cys Cys Leu Pro Val Cys Ala Val Asn Phe Lys Cys Leu His Glu Leu 
385                 390                 395                 400 


Val Lys His Glu Glu Asn Gly Leu Val Phe Glu Asp Ser Glu Glu Leu 
                405                 410                 415     


Ala Ala Gln Leu Gln Met Leu Phe Ser Asn Phe Pro Asp Pro Ala Gly 
            420                 425                 430         


Lys Leu Asn Gln Phe Arg Lys Asn Leu Arg Glu Ser Gln Gln Leu Arg 
        435                 440                 445             


Trp Asp Glu Ser Trp Val Gln Thr Val Leu Pro Leu Val Met Asp Thr 
    450                 455                 460                 


<210>  4566
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  4566

Met Ala Ile Ser Gly Val Pro Val Leu Gly Phe Phe Ile Ile Ala Val 
1               5                   10                  15      


Leu Met Ser Ala Gln Glu Ser Trp Ala Ile Lys Glu Glu His Val Ile 
            20                  25                  30          


Ile Gln Ala Glu Phe Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met 
        35                  40                  45              


Phe Asp Phe Asp Gly Asp Glu Ile Phe His Val Asp Met Ala Lys Lys 
    50                  55                  60                  


Glu Thr Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu 
65                  70                  75                  80  


Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu 
                85                  90                  95      


Ile Met Thr Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro 
            100                 105                 110         


Glu Val Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn 
        115                 120                 125             


Val Leu Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val 
    130                 135                 140                 


Thr Trp Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr 
145                 150                 155                 160 


Val Phe Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu 
                165                 170                 175     


Pro Phe Leu Pro Ser Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Phe Asp Ala Pro 
        195                 200                 205             


Ser Pro Leu Pro Glu Thr Thr Glu Asn Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Thr Val Gly Leu Val Gly Ile Ile Ile Gly Thr Ile Phe Ile Ile Lys 
225                 230                 235                 240 


Gly Leu Arg Lys Ser Asn Ala Ala Glu Arg Arg Gly Pro Leu 
                245                 250                 


<210>  4567
<211>  2146
<212>  PRT
<213>  Homo sapiens

<400>  4567

Met Ala Phe Trp Thr Gln Leu Met Leu Leu Leu Trp Lys Asn Phe Met 
1               5                   10                  15      


Tyr Arg Arg Arg Gln Pro Val Gln Leu Leu Val Glu Leu Leu Trp Pro 
            20                  25                  30          


Leu Phe Leu Phe Phe Ile Leu Val Ala Val Arg His Ser His Pro Pro 
        35                  40                  45              


Leu Glu His His Glu Cys His Phe Pro Asn Lys Pro Leu Pro Ser Ala 
    50                  55                  60                  


Gly Thr Val Pro Trp Leu Gln Gly Leu Ile Cys Asn Val Asn Asn Thr 
65                  70                  75                  80  


Cys Phe Pro Gln Leu Thr Pro Gly Glu Glu Pro Gly Arg Leu Ser Asn 
                85                  90                  95      


Phe Asn Asp Ser Leu Val Ser Arg Leu Leu Ala Asp Ala Arg Thr Val 
            100                 105                 110         


Leu Gly Gly Ala Ser Ala His Arg Thr Leu Ala Gly Leu Gly Lys Leu 
        115                 120                 125             


Ile Ala Thr Leu Arg Ala Ala Arg Ser Thr Ala Gln Pro Gln Pro Thr 
    130                 135                 140                 


Lys Gln Ser Pro Leu Glu Pro Pro Met Leu Asp Val Ala Glu Leu Leu 
145                 150                 155                 160 


Thr Ser Leu Leu Arg Thr Glu Ser Leu Gly Leu Ala Leu Gly Gln Ala 
                165                 170                 175     


Gln Glu Pro Leu His Ser Leu Leu Glu Ala Ala Glu Asp Leu Ala Gln 
            180                 185                 190         


Glu Leu Leu Ala Leu Arg Ser Leu Val Glu Leu Arg Ala Leu Leu Gln 
        195                 200                 205             


Arg Pro Arg Gly Thr Ser Gly Pro Leu Glu Leu Leu Ser Glu Ala Leu 
    210                 215                 220                 


Cys Ser Val Arg Gly Pro Ser Ser Thr Val Gly Pro Ser Leu Asn Trp 
225                 230                 235                 240 


Tyr Glu Ala Ser Asp Leu Met Glu Leu Val Gly Gln Glu Pro Glu Ser 
                245                 250                 255     


Ala Leu Pro Asp Ser Ser Leu Ser Pro Ala Cys Ser Glu Leu Ile Gly 
            260                 265                 270         


Ala Leu Asp Ser His Pro Leu Ser Arg Leu Leu Trp Arg Arg Leu Lys 
        275                 280                 285             


Pro Leu Ile Leu Gly Lys Leu Leu Phe Ala Pro Asp Thr Pro Phe Thr 
    290                 295                 300                 


Arg Lys Leu Met Ala Gln Val Asn Arg Thr Phe Glu Glu Leu Thr Leu 
305                 310                 315                 320 


Leu Arg Asp Val Arg Glu Val Trp Glu Met Leu Gly Pro Arg Ile Phe 
                325                 330                 335     


Thr Phe Met Asn Asp Ser Ser Asn Val Ala Met Leu Gln Arg Leu Leu 
            340                 345                 350         


Gln Met Gln Asp Glu Gly Arg Arg Gln Pro Arg Pro Gly Gly Arg Asp 
        355                 360                 365             


His Met Glu Ala Leu Arg Ser Phe Leu Asp Pro Gly Ser Gly Gly Tyr 
    370                 375                 380                 


Ser Trp Gln Asp Ala His Ala Asp Val Gly His Leu Val Gly Thr Leu 
385                 390                 395                 400 


Gly Arg Val Thr Glu Cys Leu Ser Leu Asp Lys Leu Glu Ala Ala Pro 
                405                 410                 415     


Ser Glu Ala Ala Leu Val Ser Arg Ala Leu Gln Leu Leu Ala Glu His 
            420                 425                 430         


Arg Phe Trp Ala Gly Val Val Phe Leu Gly Pro Glu Asp Ser Ser Asp 
        435                 440                 445             


Pro Thr Glu His Pro Thr Pro Asp Leu Gly Pro Gly His Val Arg Ile 
    450                 455                 460                 


Lys Ile Arg Met Asp Ile Asp Val Val Thr Arg Thr Asn Lys Ile Arg 
465                 470                 475                 480 


Asp Arg Phe Trp Asp Pro Gly Pro Ala Ala Asp Pro Leu Thr Asp Leu 
                485                 490                 495     


Arg Tyr Val Trp Gly Gly Phe Val Tyr Leu Gln Asp Leu Val Glu Arg 
            500                 505                 510         


Ala Ala Val Arg Val Leu Ser Gly Ala Asn Pro Arg Ala Gly Leu Tyr 
        515                 520                 525             


Leu Gln Gln Met Pro Tyr Pro Cys Tyr Val Asp Asp Val Phe Leu Arg 
    530                 535                 540                 


Val Leu Ser Arg Ser Leu Pro Leu Phe Leu Thr Leu Ala Trp Ile Tyr 
545                 550                 555                 560 


Ser Val Thr Leu Thr Val Lys Ala Val Val Arg Glu Lys Glu Thr Arg 
                565                 570                 575     


Leu Arg Asp Thr Met Arg Ala Met Gly Leu Ser Arg Ala Val Leu Trp 
            580                 585                 590         


Leu Gly Trp Phe Leu Ser Cys Leu Gly Pro Phe Leu Leu Ser Ala Ala 
        595                 600                 605             


Leu Leu Val Leu Val Leu Lys Leu Gly Asp Ile Leu Pro Tyr Ser His 
    610                 615                 620                 


Pro Gly Val Val Phe Leu Phe Leu Ala Ala Phe Ala Val Ala Thr Val 
625                 630                 635                 640 


Thr Gln Ser Phe Leu Leu Ser Ala Phe Phe Ser Arg Ala Asn Leu Ala 
                645                 650                 655     


Ala Ala Cys Gly Gly Leu Ala Tyr Phe Ser Leu Tyr Leu Pro Tyr Val 
            660                 665                 670         


Leu Cys Val Ala Trp Arg Asp Arg Leu Pro Ala Gly Gly Arg Val Ala 
        675                 680                 685             


Ala Ser Leu Leu Ser Pro Val Ala Phe Gly Phe Gly Cys Glu Ser Leu 
    690                 695                 700                 


Ala Leu Leu Glu Glu Gln Gly Glu Gly Ala Gln Trp His Asn Val Gly 
705                 710                 715                 720 


Thr Arg Pro Thr Ala Asp Val Phe Ser Leu Ala Gln Val Ser Gly Leu 
                725                 730                 735     


Leu Leu Leu Asp Ala Ala Leu Tyr Gly Leu Ala Thr Trp Tyr Leu Glu 
            740                 745                 750         


Ala Val Cys Pro Gly Gln Tyr Gly Ile Pro Glu Pro Trp Asn Phe Pro 
        755                 760                 765             


Phe Arg Arg Ser Tyr Trp Cys Gly Pro Arg Pro Pro Lys Ser Pro Ala 
    770                 775                 780                 


Pro Cys Pro Thr Pro Leu Asp Pro Lys Val Leu Val Glu Glu Ala Pro 
785                 790                 795                 800 


Pro Gly Leu Ser Pro Gly Val Ser Val Arg Ser Leu Glu Lys Arg Phe 
                805                 810                 815     


Pro Gly Ser Pro Gln Pro Ala Leu Arg Gly Leu Ser Leu Asp Phe Tyr 
            820                 825                 830         


Gln Gly His Ile Thr Ala Phe Leu Gly His Asn Gly Ala Gly Lys Thr 
        835                 840                 845             


Thr Thr Leu Ser Ile Leu Ser Gly Leu Phe Pro Pro Ser Gly Gly Ser 
    850                 855                 860                 


Ala Phe Ile Leu Gly His Asp Val Arg Ser Ser Met Ala Ala Ile Arg 
865                 870                 875                 880 


Pro His Leu Gly Val Cys Pro Gln Tyr Asn Val Leu Phe Asp Met Leu 
                885                 890                 895     


Thr Val Asp Glu His Val Trp Phe Tyr Gly Arg Leu Lys Gly Leu Ser 
            900                 905                 910         


Ala Ala Val Val Gly Pro Glu Gln Asp Arg Leu Leu Gln Asp Val Gly 
        915                 920                 925             


Leu Val Ser Lys Gln Ser Val Gln Thr Arg His Leu Ser Gly Gly Met 
    930                 935                 940                 


Gln Arg Lys Leu Ser Val Ala Ile Ala Phe Val Gly Gly Ser Gln Val 
945                 950                 955                 960 


Val Ile Leu Asp Glu Pro Thr Ala Gly Val Asp Pro Ala Ser Arg Arg 
                965                 970                 975     


Gly Ile Trp Glu Leu Leu Leu Lys Tyr Arg Glu Gly Arg Thr Leu Ile 
            980                 985                 990         


Leu Ser Thr His His Leu Asp Glu  Ala Glu Leu Leu Gly  Asp Arg Val 
        995                 1000                 1005             


Ala Val  Val Ala Gly Gly Arg  Leu Cys Cys Cys Gly  Ser Pro Leu 
    1010                 1015                 1020             


Phe Leu  Arg Arg His Leu Gly  Ser Gly Tyr Tyr Leu  Thr Leu Val 
    1025                 1030                 1035             


Lys Ala  Arg Leu Pro Leu Thr  Thr Asn Glu Lys Ala  Asp Thr Asp 
    1040                 1045                 1050             


Met Glu  Gly Ser Val Asp Thr  Arg Gln Glu Lys Lys  Asn Gly Ser 
    1055                 1060                 1065             


Gln Gly  Ser Arg Val Gly Thr  Pro Gln Leu Leu Ala  Leu Val Gln 
    1070                 1075                 1080             


His Trp  Val Pro Gly Ala Arg  Leu Val Glu Glu Leu  Pro His Glu 
    1085                 1090                 1095             


Leu Val  Leu Val Leu Pro Tyr  Thr Gly Ala His Asp  Gly Ser Phe 
    1100                 1105                 1110             


Ala Thr  Leu Phe Arg Glu Leu  Asp Thr Arg Leu Ala  Glu Leu Arg 
    1115                 1120                 1125             


Leu Thr  Gly Tyr Gly Ile Ser  Asp Thr Ser Leu Glu  Glu Ile Phe 
    1130                 1135                 1140             


Leu Lys  Val Val Glu Glu Cys  Ala Ala Asp Thr Asp  Met Glu Asp 
    1145                 1150                 1155             


Gly Ser  Cys Gly Gln His Leu  Cys Thr Gly Ile Ala  Gly Leu Asp 
    1160                 1165                 1170             


Val Thr  Leu Arg Leu Lys Met  Pro Pro Gln Glu Thr  Ala Leu Glu 
    1175                 1180                 1185             


Asn Gly  Glu Pro Ala Gly Ser  Ala Pro Glu Thr Asp  Gln Gly Ser 
    1190                 1195                 1200             


Gly Pro  Asp Ala Val Gly Arg  Val Gln Gly Trp Ala  Leu Thr Arg 
    1205                 1210                 1215             


Gln Gln  Leu Gln Ala Leu Leu  Leu Lys Arg Phe Leu  Leu Ala Arg 
    1220                 1225                 1230             


Arg Ser  Arg Arg Gly Leu Phe  Ala Gln Ile Val Leu  Pro Ala Leu 
    1235                 1240                 1245             


Phe Val  Gly Leu Ala Leu Val  Phe Ser Leu Ile Val  Pro Pro Phe 
    1250                 1255                 1260             


Gly His  Tyr Pro Ala Leu Arg  Leu Ser Pro Thr Met  Tyr Gly Ala 
    1265                 1270                 1275             


Gln Val  Ser Phe Phe Ser Glu  Asp Ala Pro Gly Asp  Pro Gly Arg 
    1280                 1285                 1290             


Ala Arg  Leu Leu Glu Ala Leu  Leu Gln Glu Ala Gly  Leu Glu Glu 
    1295                 1300                 1305             


Pro Pro  Val Gln His Ser Ser  His Arg Phe Ser Ala  Pro Glu Val 
    1310                 1315                 1320             


Pro Ala  Glu Val Ala Lys Val  Leu Ala Ser Gly Asn  Trp Thr Pro 
    1325                 1330                 1335             


Glu Ser  Pro Ser Pro Ala Cys  Gln Cys Ser Arg Pro  Gly Ala Arg 
    1340                 1345                 1350             


Arg Leu  Leu Pro Asp Cys Pro  Ala Ala Ala Gly Gly  Pro Pro Pro 
    1355                 1360                 1365             


Pro Gln  Ala Val Thr Gly Ser  Gly Glu Val Val Gln  Asn Leu Thr 
    1370                 1375                 1380             


Gly Arg  Asn Leu Ser Asp Phe  Leu Val Lys Thr Tyr  Pro Arg Leu 
    1385                 1390                 1395             


Val Arg  Gln Gly Leu Lys Thr  Lys Lys Trp Val Asn  Glu Val Arg 
    1400                 1405                 1410             


Tyr Gly  Gly Phe Ser Leu Gly  Gly Arg Asp Pro Gly  Leu Pro Ser 
    1415                 1420                 1425             


Gly Gln  Glu Leu Gly Arg Ser  Val Glu Glu Leu Trp  Ala Leu Leu 
    1430                 1435                 1440             


Ser Pro  Leu Pro Gly Gly Ala  Leu Asp Arg Val Leu  Lys Asn Leu 
    1445                 1450                 1455             


Thr Ala  Trp Ala His Ser Leu  Asp Ala Gln Asp Ser  Leu Lys Ile 
    1460                 1465                 1470             


Trp Phe  Asn Asn Lys Gly Trp  His Ser Met Val Ala  Phe Val Asn 
    1475                 1480                 1485             


Arg Ala  Ser Asn Ala Ile Leu  Arg Ala His Leu Pro  Pro Gly Pro 
    1490                 1495                 1500             


Ala Arg  His Ala His Ser Ile  Thr Thr Leu Asn His  Pro Leu Asn 
    1505                 1510                 1515             


Leu Thr  Lys Glu Gln Leu Ser  Glu Gly Ala Leu Met  Ala Ser Ser 
    1520                 1525                 1530             


Val Asp  Val Leu Val Ser Ile  Cys Val Val Phe Ala  Met Ser Phe 
    1535                 1540                 1545             


Val Pro  Ala Ser Phe Thr Leu  Val Leu Ile Glu Glu  Arg Val Thr 
    1550                 1555                 1560             


Arg Ala  Lys His Leu Gln Leu  Met Gly Gly Leu Ser  Pro Thr Leu 
    1565                 1570                 1575             


Tyr Trp  Leu Gly Asn Phe Leu  Trp Asp Met Cys Asn  Tyr Leu Val 
    1580                 1585                 1590             


Pro Ala  Cys Ile Val Val Leu  Ile Phe Leu Ala Phe  Gln Gln Arg 
    1595                 1600                 1605             


Ala Tyr  Val Ala Pro Ala Asn  Leu Pro Ala Leu Leu  Leu Leu Leu 
    1610                 1615                 1620             


Leu Leu  Tyr Gly Trp Ser Ile  Thr Pro Leu Met Tyr  Pro Ala Ser 
    1625                 1630                 1635             


Phe Phe  Phe Ser Val Pro Ser  Thr Ala Tyr Val Val  Leu Thr Cys 
    1640                 1645                 1650             


Ile Asn  Leu Phe Ile Gly Ile  Asn Gly Ser Met Ala  Thr Phe Val 
    1655                 1660                 1665             


Leu Glu  Leu Phe Ser Asp Gln  Lys Leu Gln Glu Val  Ser Arg Ile 
    1670                 1675                 1680             


Leu Lys  Gln Val Phe Leu Ile  Phe Pro His Phe Cys  Leu Gly Arg 
    1685                 1690                 1695             


Gly Leu  Ile Asp Met Val Arg  Asn Gln Ala Met Ala  Asp Ala Phe 
    1700                 1705                 1710             


Glu Arg  Leu Gly Asp Arg Gln  Phe Gln Ser Pro Leu  Arg Trp Glu 
    1715                 1720                 1725             


Val Val  Gly Lys Asn Leu Leu  Ala Met Val Ile Gln  Gly Pro Leu 
    1730                 1735                 1740             


Phe Leu  Leu Phe Thr Leu Leu  Leu Gln His Arg Ser  Gln Leu Leu 
    1745                 1750                 1755             


Pro Gln  Pro Arg Val Arg Ser  Leu Pro Leu Leu Gly  Glu Glu Asp 
    1760                 1765                 1770             


Glu Asp  Val Ala Arg Glu Arg  Glu Arg Val Val Gln  Gly Ala Thr 
    1775                 1780                 1785             


Gln Gly  Asp Val Leu Val Leu  Arg Asn Leu Thr Lys  Val Tyr Arg 
    1790                 1795                 1800             


Gly Gln  Arg Met Pro Ala Val  Asp Arg Leu Cys Leu  Gly Ile Pro 
    1805                 1810                 1815             


Pro Gly  Glu Cys Phe Gly Leu  Leu Gly Val Asn Gly  Ala Gly Lys 
    1820                 1825                 1830             


Thr Ser  Thr Phe Arg Met Val  Thr Gly Asp Thr Leu  Ala Ser Arg 
    1835                 1840                 1845             


Gly Glu  Ala Val Leu Ala Gly  His Ser Val Ala Arg  Glu Pro Ser 
    1850                 1855                 1860             


Ala Ala  His Leu Ser Met Gly  Tyr Cys Pro Gln Ser  Asp Ala Ile 
    1865                 1870                 1875             


Phe Glu  Leu Leu Thr Gly Arg  Glu His Leu Glu Leu  Leu Ala Arg 
    1880                 1885                 1890             


Leu Arg  Gly Val Pro Glu Ala  Gln Val Ala Gln Thr  Ala Gly Ser 
    1895                 1900                 1905             


Gly Leu  Ala Arg Leu Gly Leu  Ser Trp Tyr Ala Asp  Arg Pro Ala 
    1910                 1915                 1920             


Gly Thr  Tyr Ser Gly Gly Asn  Lys Arg Lys Leu Ala  Thr Ala Leu 
    1925                 1930                 1935             


Ala Leu  Val Gly Asp Pro Ala  Val Val Phe Leu Asp  Glu Pro Thr 
    1940                 1945                 1950             


Thr Gly  Met Asp Pro Ser Ala  Arg Arg Phe Leu Trp  Asn Ser Leu 
    1955                 1960                 1965             


Leu Ala  Val Val Arg Glu Gly  Arg Ser Val Met Leu  Thr Ser His 
    1970                 1975                 1980             


Ser Met  Glu Glu Cys Glu Ala  Leu Cys Ser Arg Leu  Ala Ile Met 
    1985                 1990                 1995             


Val Asn  Gly Arg Phe Arg Cys  Leu Gly Ser Pro Gln  His Leu Lys 
    2000                 2005                 2010             


Gly Arg  Phe Ala Ala Gly His  Thr Leu Thr Leu Arg  Val Pro Ala 
    2015                 2020                 2025             


Ala Arg  Ser Gln Pro Ala Ala  Ala Phe Val Ala Ala  Glu Phe Pro 
    2030                 2035                 2040             


Gly Ala  Glu Leu Arg Glu Ala  His Gly Gly Arg Leu  Arg Phe Gln 
    2045                 2050                 2055             


Leu Pro  Pro Gly Gly Arg Cys  Ala Leu Ala Arg Val  Phe Gly Glu 
    2060                 2065                 2070             


Leu Ala  Val His Gly Ala Glu  His Gly Val Glu Asp  Phe Ser Val 
    2075                 2080                 2085             


Ser Gln  Thr Met Leu Glu Glu  Val Phe Leu Tyr Phe  Ser Lys Asp 
    2090                 2095                 2100             


Gln Gly  Lys Asp Glu Asp Thr  Glu Glu Gln Lys Glu  Ala Gly Val 
    2105                 2110                 2115             


Gly Val  Asp Pro Ala Pro Gly  Leu Gln His Pro Lys  Arg Val Ser 
    2120                 2125                 2130             


Gln Phe  Leu Asp Asp Pro Ser  Thr Ala Glu Thr Val  Leu 
    2135                 2140                 2145     


<210>  4568
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  4568

Met Ala Ala Ser Leu Gly Gln Val Leu Ala Leu Val Leu Val Ala Ala 
1               5                   10                  15      


Leu Trp Gly Gly Thr Gln Pro Leu Leu Lys Arg Ala Ser Ala Gly Leu 
            20                  25                  30          


Gln Arg Val His Glu Pro Thr Trp Ala Gln Gln Leu Leu Gln Glu Met 
        35                  40                  45              


Lys Thr Leu Phe Leu Asn Thr Glu Tyr Leu Met Pro Phe Leu Leu Asn 
    50                  55                  60                  


Gln Cys Gly Ser Leu Leu Tyr Tyr Leu Thr Leu Ala Ser Thr Asp Leu 
65                  70                  75                  80  


Thr Leu Ala Val Pro Ile Cys Asn Ser Leu Ala Ile Ile Phe Thr Leu 
                85                  90                  95      


Ile Val Gly Lys Ala Leu Gly Glu Asp Ile Gly Gly Lys Arg Ala Val 
            100                 105                 110         


Ala Gly Met Val Leu Thr Val Ile Gly Ile Ser Leu Cys Ile Thr Ser 
        115                 120                 125             


Ser Val Ser Lys Thr Gln Gly Gln Gln Ser Thr Leu 
    130                 135                 140 


<210>  4569
<211>  800
<212>  PRT
<213>  Homo sapiens

<400>  4569

Met Ala Val Arg Glu Leu Cys Phe Pro Arg Gln Arg Gln Val Leu Phe 
1               5                   10                  15      


Leu Phe Leu Phe Trp Gly Val Ser Leu Ala Gly Ser Gly Phe Gly Arg 
            20                  25                  30          


Tyr Ser Val Thr Glu Glu Thr Glu Lys Gly Ser Phe Val Val Asn Leu 
        35                  40                  45              


Ala Lys Asp Leu Gly Leu Ala Glu Gly Glu Leu Ala Ala Arg Gly Thr 
    50                  55                  60                  


Arg Val Val Ser Asp Asp Asn Lys Gln Tyr Leu Leu Leu Asp Ser His 
65                  70                  75                  80  


Thr Gly Asn Leu Leu Thr Asn Glu Lys Leu Asp Arg Glu Lys Leu Cys 
                85                  90                  95      


Gly Pro Lys Glu Pro Cys Met Leu Tyr Phe Gln Ile Leu Met Asp Asp 
            100                 105                 110         


Pro Phe Gln Ile Tyr Arg Ala Glu Leu Arg Val Arg Asp Ile Asn Asp 
        115                 120                 125             


His Ala Pro Val Phe Gln Asp Lys Glu Thr Val Leu Lys Ile Ser Glu 
    130                 135                 140                 


Asn Thr Ala Glu Gly Thr Ala Phe Arg Leu Glu Arg Ala Gln Asp Pro 
145                 150                 155                 160 


Asp Gly Gly Leu Asn Gly Ile Gln Asn Tyr Thr Ile Ser Pro Asn Ser 
                165                 170                 175     


Phe Phe His Ile Asn Ile Ser Gly Gly Asp Glu Gly Met Ile Tyr Pro 
            180                 185                 190         


Glu Leu Val Leu Asp Lys Ala Leu Asp Arg Glu Glu Gln Gly Glu Leu 
        195                 200                 205             


Ser Leu Thr Leu Thr Ala Leu Asp Gly Gly Ser Pro Ser Arg Ser Gly 
    210                 215                 220                 


Thr Ser Thr Val Arg Ile Val Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Gln Phe Ala Gln Ala Leu Tyr Glu Thr Gln Ala Pro Glu Asn Ser Pro 
                245                 250                 255     


Ile Gly Phe Leu Ile Val Lys Val Trp Ala Glu Asp Val Asp Ser Gly 
            260                 265                 270         


Val Asn Ala Glu Val Ser Tyr Ser Phe Phe Asp Ala Ser Glu Asn Ile 
        275                 280                 285             


Arg Thr Thr Phe Gln Ile Asn Pro Phe Ser Gly Glu Ile Phe Leu Arg 
    290                 295                 300                 


Glu Leu Leu Asp Tyr Glu Leu Val Asn Ser Tyr Lys Ile Asn Ile Gln 
305                 310                 315                 320 


Ala Met Asp Gly Gly Gly Leu Ser Ala Arg Cys Arg Val Leu Val Glu 
                325                 330                 335     


Val Leu Asp Thr Asn Asp Asn Pro Pro Glu Leu Ile Val Ser Ser Phe 
            340                 345                 350         


Ser Asn Ser Val Ala Glu Asn Ser Pro Glu Thr Pro Leu Ala Val Phe 
        355                 360                 365             


Lys Ile Asn Asp Arg Asp Ser Gly Glu Asn Gly Lys Met Val Cys Tyr 
    370                 375                 380                 


Ile Gln Glu Asn Leu Pro Phe Leu Leu Lys Pro Ser Val Glu Asn Phe 
385                 390                 395                 400 


Tyr Ile Leu Ile Thr Glu Gly Ala Leu Asp Arg Glu Ile Arg Ala Glu 
                405                 410                 415     


Tyr Asn Ile Thr Ile Thr Val Thr Asp Leu Gly Thr Pro Arg Leu Lys 
            420                 425                 430         


Thr Glu His Asn Ile Thr Val Leu Val Ser Asp Val Asn Asp Asn Ala 
        435                 440                 445             


Pro Ala Phe Thr Gln Thr Ser Tyr Thr Leu Phe Val Arg Glu Asn Asn 
    450                 455                 460                 


Ser Pro Ala Leu His Ile Gly Ser Val Ser Ala Thr Asp Arg Asp Ser 
465                 470                 475                 480 


Gly Thr Asn Ala Gln Val Thr Tyr Ser Leu Leu Pro Pro Gln Asp Pro 
                485                 490                 495     


His Leu Pro Leu Ala Ser Leu Val Ser Ile Asn Ala Asp Asn Gly His 
            500                 505                 510         


Leu Phe Ala Leu Arg Ser Leu Asp Tyr Glu Ala Leu Gln Ala Phe Glu 
        515                 520                 525             


Phe Arg Val Gly Ala Thr Asp Arg Gly Ser Pro Ala Leu Ser Arg Glu 
    530                 535                 540                 


Ala Leu Val Arg Val Leu Val Leu Asp Ala Asn Asp Asn Ser Pro Phe 
545                 550                 555                 560 


Val Leu Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu Leu Val 
                565                 570                 575     


Pro Arg Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val 
            580                 585                 590         


Asp Gly Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu Lys 
        595                 600                 605             


Ala Thr Glu Pro Gly Leu Phe Gly Val Trp Ala His Asn Gly Glu Val 
    610                 615                 620                 


Arg Thr Ala Arg Leu Leu Ser Glu Arg Asp Ala Ala Lys His Arg Leu 
625                 630                 635                 640 


Val Val Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr Ala 
                645                 650                 655     


Thr Leu His Leu Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr Leu Pro 
            660                 665                 670         


Leu Pro Glu Ala Ala Pro Ala Gln Ala Gln Ala Glu Ala Asp Leu Leu 
        675                 680                 685             


Thr Val Tyr Leu Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu 
    690                 695                 700                 


Leu Ser Val Leu Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg 
705                 710                 715                 720 


Ala Ala Ser Val Gly Arg Cys Ser Val Pro Glu Gly Pro Phe Pro Gly 
                725                 730                 735     


His Leu Val Asp Val Arg Gly Ala Glu Thr Leu Ser Gln Ser Tyr Gln 
            740                 745                 750         


Tyr Glu Val Cys Leu Thr Gly Gly Pro Gly Thr Ser Glu Phe Lys Phe 
        755                 760                 765             


Leu Lys Pro Val Ile Ser Asp Ile Gln Ala Gln Gly Pro Gly Arg Lys 
    770                 775                 780                 


Gly Glu Glu Asn Ser Thr Phe Arg Asn Ser Phe Gly Phe Asn Ile Gln 
785                 790                 795                 800 


<210>  4570
<211>  797
<212>  PRT
<213>  Homo sapiens

<400>  4570

Met Lys Thr Arg Gly Phe Ser Phe Pro Arg Gln Arg Gln Val Leu Phe 
1               5                   10                  15      


Leu Phe Leu Phe Trp Gly Val Ser Leu Ala Gly Ser Gly Phe Gly Arg 
            20                  25                  30          


Tyr Ser Val Thr Glu Glu Thr Glu Lys Gly Ser Phe Val Val Asn Leu 
        35                  40                  45              


Ala Lys Asp Leu Gly Leu Ala Glu Gly Glu Leu Ala Ala Arg Gly Thr 
    50                  55                  60                  


Arg Val Val Ser Asp Asp Asn Lys Gln Tyr Leu Leu Leu Asp Ser His 
65                  70                  75                  80  


Thr Gly Asn Leu Leu Thr Asn Glu Lys Leu Asp Arg Glu Lys Leu Cys 
                85                  90                  95      


Gly Pro Lys Glu Pro Cys Met Leu Tyr Phe Gln Ile Leu Met Asp Asp 
            100                 105                 110         


Pro Phe Gln Ile Tyr Arg Ala Glu Leu Arg Val Arg Asp Ile Asn Asp 
        115                 120                 125             


His Ser Pro Val Phe Arg His Lys Glu Met Val Leu Lys Ile Ser Glu 
    130                 135                 140                 


Asn Thr Ala Glu Gly Thr Ala Phe Arg Leu Glu Arg Ala Gln Asp Pro 
145                 150                 155                 160 


Asp Glu Gly His Asn Ser Ile Gln Asn Tyr Thr Ile Ser Ser Asn Ser 
                165                 170                 175     


Phe Phe His Ile Lys Ile Ser Gly Ser Asp Glu Gly Met Ile Tyr Pro 
            180                 185                 190         


Glu Leu Val Leu Asp Lys Ala Leu Asp Arg Glu Glu Gln Glu Glu Leu 
        195                 200                 205             


Ser Leu Thr Leu Thr Ala Leu Asp Gly Gly Ser Pro Ser Arg Ser Gly 
    210                 215                 220                 


Thr Ser Thr Ile Arg Ile Val Val Leu Asp Val Asn Asp Asn Val Pro 
225                 230                 235                 240 


Gln Phe Ala Gln Ala Leu Tyr Glu Thr Gln Ala Pro Glu Asn Ser Pro 
                245                 250                 255     


Val Gly Ser Leu Ile Val Lys Val Ser Ala Gly Asp Ala Asp Ser Gly 
            260                 265                 270         


Val Asn Ala Glu Val Ser Tyr Ser Phe Phe Asp Ala Ser Glu Asp Ile 
        275                 280                 285             


Leu Thr Thr Phe Gln Ile Asn Pro Phe Ser Gly Glu Ile Phe Leu Arg 
    290                 295                 300                 


Glu Leu Leu Asp Tyr Glu Leu Val Asn Ser Tyr Lys Ile Asn Ile Gln 
305                 310                 315                 320 


Ala Met Asp Gly Gly Gly Leu Ser Ala Arg Cys Thr Val Leu Ile Lys 
                325                 330                 335     


Val Leu Asp Ser Asn Asp Asn Pro Pro Glu Leu Ile Ile Ser Ser Leu 
            340                 345                 350         


Ser Asn Ser Val Ala Glu Asn Ser Pro Gly Ile Val Leu Ala Val Phe 
        355                 360                 365             


Lys Ile Lys Asp Arg Asp Ser Gly Glu Asn Gly Lys Thr Ile Cys Tyr 
    370                 375                 380                 


Val Gln Asp Asn Leu Pro Phe Phe Leu Lys Pro Ser Val Asp Asn Phe 
385                 390                 395                 400 


Tyr Ile Leu Met Thr Glu Gly Ala Leu Asp Arg Glu Ser Lys Ala Glu 
                405                 410                 415     


Tyr Asn Ile Thr Ile Thr Val Thr Asp Leu Gly Thr Pro Arg Leu Lys 
            420                 425                 430         


Thr Glu His Ser Ile Thr Leu Gln Val Ser Asp Val Asn Asp Asn Ala 
        435                 440                 445             


Pro Ala Phe Thr Gln Thr Ser Tyr Thr Leu Phe Val Arg Glu Asn Asn 
    450                 455                 460                 


Ser Pro Ala Leu His Ile Gly Ser Val Ser Ala Thr Asp Arg Asp Ser 
465                 470                 475                 480 


Gly Thr Asn Ala Gln Val Thr Tyr Ser Leu Leu Pro Pro Gln Asp Pro 
                485                 490                 495     


His Leu Pro Leu Ala Ser Leu Val Ser Ile Asn Ala Asp Asn Gly His 
            500                 505                 510         


Leu Phe Ala Leu Arg Ser Leu Asp Tyr Glu Ala Leu Gln Ala Phe Asp 
        515                 520                 525             


Phe Arg Val Gly Ala Ser Asp Arg Gly Ser Pro Ala Leu Ser Ser Glu 
    530                 535                 540                 


Ala Leu Val Arg Val Leu Val Leu Asp Ala Asn Asp Asn Ser Pro Phe 
545                 550                 555                 560 


Val Leu Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu Leu Val 
                565                 570                 575     


Pro Arg Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val 
            580                 585                 590         


Asp Gly Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu Lys 
        595                 600                 605             


Ala Thr Glu Pro Gly Leu Phe Gly Val Trp Ala His Asn Gly Glu Val 
    610                 615                 620                 


Arg Thr Ala Arg Leu Leu Ser Glu Arg Asp Ala Ala Lys His Arg Leu 
625                 630                 635                 640 


Val Val Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr Ala 
                645                 650                 655     


Thr Leu His Val Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr Leu Pro 
            660                 665                 670         


Leu Pro Glu Ala Ala Pro Ala Gln Ala Gln Ala Asp Leu Leu Thr Val 
        675                 680                 685             


Tyr Leu Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu Leu Ser 
    690                 695                 700                 


Val Leu Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg Ala Ala 
705                 710                 715                 720 


Ser Val Gly Arg Cys Ser Val Pro Glu Gly Pro Phe Pro Gly His Leu 
                725                 730                 735     


Val Asp Val Ser Gly Thr Gly Thr Leu Phe Gln Ser Tyr Gln Tyr Glu 
            740                 745                 750         


Val Cys Leu Thr Gly Gly Ser Glu Thr Gly Glu Phe Lys Phe Leu Lys 
        755                 760                 765             


Pro Ile Thr Pro His Leu Pro Pro His Arg Gly Gly Lys Glu Ile Glu 
    770                 775                 780                 


Glu Asn Ser Thr Leu Pro Asn Ser Phe Gly Phe Asn Tyr 
785                 790                 795         


<210>  4571
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  4571

Met His Gln Gln Lys Arg Gln Pro Glu Leu Val Glu Gly Asn Leu Pro 
1               5                   10                  15      


Val Phe Val Phe Pro Thr Glu Leu Ile Phe Tyr Ala Asp Asp Gln Ser 
            20                  25                  30          


Thr His Lys Gln Val Leu Thr Leu Tyr Asn Pro Tyr Glu Phe Ala Leu 
        35                  40                  45              


Lys Phe Lys Val Leu Cys Thr Thr Pro Asn Lys Tyr Val Val Val Asp 
    50                  55                  60                  


Ala Ala Gly Ala Val Lys Pro Gln Cys Cys Val Asp Ile Val Ile Arg 
65                  70                  75                  80  


His Arg Asp Val Arg Ser Cys His Tyr Gly Val Ile Asp Lys Phe Arg 
                85                  90                  95      


Leu Gln Val Ser Glu Gln Ser Gln Arg Lys Ala Leu Gly Arg Lys Glu 
            100                 105                 110         


Val Val Ala Thr Leu Leu Pro Ser Ala Lys Glu Gln Gln Lys Glu Glu 
        115                 120                 125             


Glu Glu Lys Arg Leu Lys Glu His Leu Thr Glu Ser Leu Phe Phe Glu 
    130                 135                 140                 


Gln Ser Phe Gln Pro Glu Asn Arg Ala Val Ser Ser Gly Pro Ser Leu 
145                 150                 155                 160 


Leu Thr Val Phe Leu Gly Val Val Cys Ile Ala Ala Leu Met Leu Pro 
                165                 170                 175     


Thr Leu Gly Asp Val Glu Ser Leu Val Pro Leu Tyr Leu His Leu Ser 
            180                 185                 190         


Val Asn Gln Lys Leu Val Ala Ala Tyr Ile Leu Gly Leu Ile Thr Met 
        195                 200                 205             


Ala Ile Leu Arg Thr 
    210             


<210>  4572
<211>  810
<212>  PRT
<213>  Homo sapiens

<400>  4572

Met Ile Pro Val Thr Glu Leu Arg Tyr Phe Ala Asp Thr Gln Pro Ala 
1               5                   10                  15      


Tyr Arg Ile Leu Lys Pro Trp Trp Asp Val Phe Thr Asp Tyr Ile Ser 
            20                  25                  30          


Ile Val Met Leu Met Ile Ala Val Phe Gly Gly Thr Leu Gln Val Thr 
        35                  40                  45              


Gln Asp Lys Met Ile Cys Leu Pro Cys Lys Trp Val Thr Lys Asp Ser 
    50                  55                  60                  


Cys Asn Asp Ser Phe Arg Gly Trp Ala Ala Pro Gly Pro Glu Pro Thr 
65                  70                  75                  80  


Tyr Pro Asn Ser Thr Ile Leu Pro Thr Pro Asp Thr Gly Pro Thr Gly 
                85                  90                  95      


Ile Lys Tyr Asp Leu Asp Arg His Gln Tyr Asn Tyr Val Asp Ala Val 
            100                 105                 110         


Cys Tyr Glu Asn Arg Leu His Trp Phe Ala Lys Tyr Phe Pro Tyr Leu 
        115                 120                 125             


Val Leu Leu His Thr Leu Ile Phe Leu Ala Cys Ser Asn Phe Trp Phe 
    130                 135                 140                 


Lys Phe Pro Arg Thr Ser Ser Lys Leu Glu His Phe Val Ser Ile Leu 
145                 150                 155                 160 


Leu Lys Cys Phe Asp Ser Pro Trp Thr Thr Arg Ala Leu Ser Glu Thr 
                165                 170                 175     


Val Val Glu Glu Ser Asp Pro Lys Pro Ala Phe Ser Lys Met Asn Gly 
            180                 185                 190         


Ser Met Asp Lys Lys Ser Ser Thr Val Ser Glu Asp Val Glu Ala Thr 
        195                 200                 205             


Val Pro Met Leu Gln Arg Thr Lys Ser Arg Ile Glu Gln Gly Ile Val 
    210                 215                 220                 


Asp Arg Ser Glu Thr Gly Val Leu Asp Lys Lys Glu Gly Glu Gln Ala 
225                 230                 235                 240 


Lys Ala Leu Phe Glu Lys Val Lys Lys Phe Arg Thr His Val Glu Glu 
                245                 250                 255     


Gly Asp Ile Val Tyr Arg Leu Tyr Met Arg Gln Thr Ile Ile Lys Val 
            260                 265                 270         


Ile Lys Phe Ile Leu Ile Ile Cys Tyr Thr Val Tyr Tyr Val His Asn 
        275                 280                 285             


Ile Lys Phe Asp Val Asp Cys Thr Val Asp Ile Glu Ser Leu Thr Gly 
    290                 295                 300                 


Tyr Arg Thr Tyr Arg Cys Ala His Pro Leu Ala Thr Leu Phe Lys Ile 
305                 310                 315                 320 


Leu Ala Ser Phe Tyr Ile Ser Leu Val Ile Phe Tyr Gly Leu Ile Cys 
                325                 330                 335     


Met Tyr Thr Leu Trp Trp Met Leu Arg Arg Ser Leu Lys Lys Tyr Ser 
            340                 345                 350         


Phe Glu Ser Ile Arg Glu Glu Ser Ser Tyr Ser Asp Ile Pro Asp Val 
        355                 360                 365             


Lys Asn Asp Phe Ala Phe Met Leu His Leu Ile Asp Gln Tyr Asp Pro 
    370                 375                 380                 


Leu Tyr Ser Lys Arg Phe Ala Val Phe Leu Ser Glu Val Ser Glu Asn 
385                 390                 395                 400 


Lys Leu Arg Gln Leu Asn Leu Asn Asn Glu Trp Thr Leu Asp Lys Leu 
                405                 410                 415     


Arg Gln Arg Leu Thr Lys Asn Ala Gln Asp Lys Leu Glu Leu His Leu 
            420                 425                 430         


Phe Met Leu Ser Gly Ile Pro Asp Thr Val Phe Asp Leu Val Glu Leu 
        435                 440                 445             


Glu Val Leu Lys Leu Glu Leu Ile Pro Asp Val Thr Ile Pro Pro Ser 
    450                 455                 460                 


Ile Ala Gln Leu Thr Gly Leu Lys Glu Leu Trp Leu Tyr His Thr Ala 
465                 470                 475                 480 


Ala Lys Ile Glu Ala Pro Ala Leu Ala Phe Leu Arg Glu Asn Leu Arg 
                485                 490                 495     


Ala Leu His Ile Lys Phe Thr Asp Ile Lys Glu Ile Pro Leu Trp Ile 
            500                 505                 510         


Tyr Ser Leu Lys Thr Leu Glu Glu Leu His Leu Thr Gly Asn Leu Ser 
        515                 520                 525             


Ala Glu Asn Asn Arg Tyr Ile Val Ile Asp Gly Leu Arg Glu Leu Lys 
    530                 535                 540                 


Arg Leu Lys Val Leu Arg Leu Lys Ser Asn Leu Ser Lys Leu Pro Gln 
545                 550                 555                 560 


Val Val Thr Asp Val Gly Val His Leu Gln Lys Leu Ser Ile Asn Asn 
                565                 570                 575     


Glu Gly Thr Lys Leu Ile Val Leu Asn Ser Leu Lys Lys Met Ala Asn 
            580                 585                 590         


Leu Thr Glu Leu Glu Leu Ile Arg Cys Asp Leu Glu Arg Ile Pro His 
        595                 600                 605             


Ser Ile Phe Ser Leu His Asn Leu Gln Glu Ile Asp Leu Lys Asp Asn 
    610                 615                 620                 


Asn Leu Lys Thr Ile Glu Glu Ile Ile Ser Phe Gln His Leu His Arg 
625                 630                 635                 640 


Leu Thr Cys Leu Lys Leu Trp Tyr Asn His Ile Ala Tyr Ile Pro Ile 
                645                 650                 655     


Gln Ile Gly Asn Leu Thr Asn Leu Glu Arg Leu Tyr Leu Asn Arg Asn 
            660                 665                 670         


Lys Ile Glu Lys Ile Pro Thr Gln Leu Phe Tyr Cys Arg Lys Leu Arg 
        675                 680                 685             


Tyr Leu Asp Leu Ser His Asn Asn Leu Thr Phe Leu Pro Ala Asp Ile 
    690                 695                 700                 


Gly Leu Leu Gln Asn Leu Gln Asn Leu Ala Ile Thr Ala Asn Arg Ile 
705                 710                 715                 720 


Glu Thr Leu Pro Pro Glu Leu Phe Gln Cys Arg Lys Leu Arg Ala Leu 
                725                 730                 735     


His Leu Gly Asn Asn Val Leu Gln Ser Leu Pro Ser Arg Val Gly Glu 
            740                 745                 750         


Leu Thr Asn Leu Thr Gln Ile Glu Leu Arg Gly Asn Arg Leu Glu Cys 
        755                 760                 765             


Leu Pro Val Glu Leu Gly Glu Cys Pro Leu Leu Lys Arg Ser Gly Leu 
    770                 775                 780                 


Val Val Glu Glu Asp Leu Phe Asn Thr Leu Pro Pro Glu Val Lys Glu 
785                 790                 795                 800 


Arg Leu Trp Arg Ala Asp Lys Glu Gln Ala 
                805                 810 


<210>  4573
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  4573

Met Leu Glu Ser His Leu Ile Ile Tyr Phe Leu Leu Ala Val Ile Gln 
1               5                   10                  15      


Phe Leu Leu Gly Ile Phe Thr Asn Gly Ile Ile Val Val Val Asn Gly 
            20                  25                  30          


Ile Asp Leu Ile Lys His Arg Lys Met Ala Pro Leu Asp Leu Leu Leu 
        35                  40                  45              


Ser Cys Leu Ala Val Ser Arg Ile Phe Leu Gln Leu Phe Ile Phe Tyr 
    50                  55                  60                  


Val Asn Val Ile Val Ile Phe Phe Ile Glu Phe Ile Met Cys Ser Ala 
65                  70                  75                  80  


Asn Cys Ala Ile Leu Leu Phe Ile Asn Glu Leu Glu Leu Trp Leu Ala 
                85                  90                  95      


Thr Trp Leu Gly Val Phe Tyr Cys Ala Lys Val Ala Ser Val Arg His 
            100                 105                 110         


Pro Leu Phe Ile Trp Leu Lys Met Arg Ile Ser Lys Leu Val Pro Trp 
        115                 120                 125             


Met Ile Leu Gly Ser Leu Leu Tyr Val Ser Met Ile Cys Val Phe His 
    130                 135                 140                 


Ser Lys Tyr Ala Gly Phe Met Val Pro Tyr Phe Leu Arg Lys Phe Phe 
145                 150                 155                 160 


Ser Gln Asn Ala Thr Ile Gln Lys Glu Asp Thr Leu Ala Ile Gln Ile 
                165                 170                 175     


Phe Ser Phe Val Ala Glu Phe Ser Val Pro Leu Leu Ile Phe Leu Phe 
            180                 185                 190         


Ala Val Leu Leu Leu Ile Phe Ser Leu Gly Arg His Thr Arg Gln Met 
        195                 200                 205             


Arg Asn Thr Val Ala Gly Ser Arg Val Pro Gly Arg Gly Ala Pro Ile 
    210                 215                 220                 


Ser Ala Leu Leu Ser Ile Leu Ser Phe Leu Ile Leu Tyr Phe Ser His 
225                 230                 235                 240 


Cys Met Ile Lys Val Phe Leu Ser Ser Leu Lys Phe His Ile Arg Arg 
                245                 250                 255     


Phe Ile Phe Leu Phe Phe Ile Leu Val Ile Gly Ile Tyr Pro Ser Gly 
            260                 265                 270         


His Ser Leu Ile Leu Ile Leu Gly Asn Pro Lys Leu Lys Gln Asn Ala 
        275                 280                 285             


Lys Lys Phe Leu Leu His Ser Lys Cys Cys Gln 
    290                 295                 


<210>  4574
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  4574

Met Val Asp Phe Pro Gly Tyr Asn Leu Ser Gly Ala Val Ala Ser Phe 
1               5                   10                  15      


Leu Phe Ile Leu Leu Thr Met Lys Gln Ser Glu Asp Phe Arg Val Ile 
            20                  25                  30          


Gly Pro Ala His Pro Ile Leu Ala Gly Val Gly Glu Asp Ala Leu Leu 
        35                  40                  45              


Thr Cys Gln Leu Leu Pro Lys Arg Thr Thr Met His Val Glu Val Arg 
    50                  55                  60                  


Trp Tyr Arg Ser Glu Pro Ser Thr Pro Val Phe Val His Arg Asp Gly 
65                  70                  75                  80  


Val Glu Val Thr Glu Met Gln Met Glu Glu Tyr Arg Gly Trp Val Glu 
                85                  90                  95      


Trp Ile Glu Asn Gly Ile Ala Lys Gly Asn Val Ala Leu Lys Ile His 
            100                 105                 110         


Asn Ile Gln Pro Ser Asp Asn Gly Gln Tyr Trp Cys His Phe Gln Asp 
        115                 120                 125             


Gly Asn Tyr Cys Gly Glu Thr Ser Leu Leu Leu Lys Val Ala Gly Leu 
    130                 135                 140                 


Gly Ser Ala Pro Ser Ile His Met Glu Gly Pro Gly Glu Ser Gly Val 
145                 150                 155                 160 


Gln Leu Val Cys Thr Ala Arg Gly Trp Phe Pro Glu Pro Gln Val Tyr 
                165                 170                 175     


Trp Glu Asp Ile Arg Gly Glu Lys Leu Leu Ala Val Ser Glu His Arg 
            180                 185                 190         


Ile Gln Asp Lys Asp Gly Leu Phe Tyr Ala Glu Ala Thr Leu Val Val 
        195                 200                 205             


Arg Asn Ala Ser Ala Glu Ser Val Ser Cys Leu Val His Asn Pro Val 
    210                 215                 220                 


Leu Thr Glu Glu Lys Gly Ser Val Ile Ser Leu Pro Glu Lys Leu Gln 
225                 230                 235                 240 


Thr Glu Leu Ala Ser Leu Lys Val Asn Gly Pro Ser Gln Pro Ile Leu 
                245                 250                 255     


Val Arg Val Gly Glu Asp Ile Gln Leu Thr Cys Tyr Leu Ser Pro Lys 
            260                 265                 270         


Ala Asn Ala Gln Ser Met Glu Val Arg Trp Asp Arg Ser His Arg Tyr 
        275                 280                 285             


Pro Ala Val His Val Tyr Met Asp Gly Asp His Val Ala Gly Glu Gln 
    290                 295                 300                 


Met Ala Glu Tyr Arg Gly Arg Thr Val Leu Val Ser Asp Ala Ile Asp 
305                 310                 315                 320 


Glu Gly Arg Leu Thr Leu Gln Ile Leu Ser Ala Arg Pro Ser Asp Asp 
                325                 330                 335     


Gly Gln Tyr Arg Cys Leu Phe Glu Lys Asp Asp Val Tyr Gln Glu Ala 
            340                 345                 350         


Ser Leu Asp Leu Lys Val Val Ser Leu Gly Ser Ser Pro Leu Ile Thr 
        355                 360                 365             


Val Glu Gly Gln Glu Asp Gly Glu Met Gln Pro Met Cys Ser Ser Asp 
    370                 375                 380                 


Gly Trp Phe Pro Gln Pro His Val Pro Trp Arg Asp Met Glu Gly Lys 
385                 390                 395                 400 


Thr Ile Pro Ser Ser Ser Gln Ala Leu Thr Gln Gly Ser His Gly Leu 
                405                 410                 415     


Phe His Val Gln Thr Leu Leu Arg Val Thr Asn Ile Ser Ala Val Asp 
            420                 425                 430         


Val Thr Cys Ser Ile Ser Ile Pro Phe Leu Gly Glu Glu Lys Ile Ala 
        435                 440                 445             


Thr Phe Ser Leu Ser Glu Ser Arg Met Thr Phe Leu Trp Lys Thr Leu 
    450                 455                 460                 


Leu Val Trp Gly Leu Leu Leu Ala Val Ala Val Gly Leu Pro Arg Lys 
465                 470                 475                 480 


Arg Ser 
        


<210>  4575
<211>  822
<212>  PRT
<213>  Homo sapiens

<400>  4575

Met Lys Pro Ala Leu Leu Pro Trp Ala Leu Leu Leu Leu Ala Thr Ala 
1               5                   10                  15      


Leu Gly Pro Gly Pro Gly Pro Thr Ala Asp Ala Gln Glu Ser Cys Ser 
            20                  25                  30          


Met Arg Cys Gly Ala Leu Asp Gly Pro Cys Ser Cys His Pro Thr Cys 
        35                  40                  45              


Ser Gly Leu Gly Thr Cys Cys Leu Asp Phe Arg Asp Phe Cys Leu Glu 
    50                  55                  60                  


Ile Leu Pro Tyr Ser Gly Ser Met Met Gly Gly Lys Asp Phe Val Val 
65                  70                  75                  80  


Arg His Phe Lys Met Ser Ser Pro Thr Asp Ala Ser Val Ile Cys Arg 
                85                  90                  95      


Phe Lys Asp Ser Ile Gln Thr Leu Gly His Val Asp Ser Ser Gly Gln 
            100                 105                 110         


Val His Cys Val Ser Pro Leu Leu Tyr Glu Ser Gly Arg Ile Pro Phe 
        115                 120                 125             


Thr Val Ser Leu Asp Asn Gly His Ser Phe Pro Arg Ala Gly Thr Trp 
    130                 135                 140                 


Leu Ala Val His Pro Asn Lys Val Ser Met Met Glu Lys Ser Glu Leu 
145                 150                 155                 160 


Val Asn Glu Thr Arg Trp Gln Tyr Tyr Gly Thr Ala Asn Thr Ser Gly 
                165                 170                 175     


Asn Leu Ser Leu Thr Trp His Val Lys Ser Leu Pro Thr Gln Thr Ile 
            180                 185                 190         


Thr Ile Glu Leu Trp Gly Tyr Glu Glu Thr Gly Met Pro Tyr Ser Gln 
        195                 200                 205             


Glu Trp Thr Ala Lys Trp Ser Tyr Leu Tyr Pro Leu Ala Thr His Ile 
    210                 215                 220                 


Pro Asn Ser Gly Ser Phe Thr Phe Thr Pro Lys Pro Ala Pro Pro Ser 
225                 230                 235                 240 


Tyr Gln Arg Trp Arg Val Gly Ala Leu Arg Ile Ile Asp Ser Lys Asn 
                245                 250                 255     


Tyr Ala Gly Gln Lys Asp Val Gln Ala Leu Trp Thr Asn Asp His Ala 
            260                 265                 270         


Leu Ala Trp His Leu Ser Asp Asp Phe Arg Glu Asp Pro Val Ala Trp 
        275                 280                 285             


Ala Arg Thr Gln Cys Gln Ala Trp Glu Glu Leu Glu Asp Gln Leu Pro 
    290                 295                 300                 


Asn Phe Leu Glu Glu Leu Pro Asp Cys Pro Cys Thr Leu Thr Gln Ala 
305                 310                 315                 320 


Arg Ala Asp Ser Gly Arg Phe Phe Thr Asp Tyr Gly Cys Asp Met Glu 
                325                 330                 335     


Gln Gly Ser Val Cys Thr Tyr His Pro Gly Ala Val His Cys Val Arg 
            340                 345                 350         


Ser Val Gln Ala Ser Leu Arg Tyr Gly Ser Gly Gln Gln Cys Cys Tyr 
        355                 360                 365             


Thr Ala Asp Gly Thr Gln Leu Leu Thr Ala Asp Ser Ser Gly Gly Ser 
    370                 375                 380                 


Thr Pro Asp Arg Gly His Asp Trp Gly Ala Pro Pro Phe Arg Thr Pro 
385                 390                 395                 400 


Pro Arg Val Pro Ser Met Ser His Trp Leu Tyr Asp Val Leu Ser Phe 
                405                 410                 415     


Tyr Tyr Cys Cys Leu Trp Ala Pro Asp Cys Pro Arg Tyr Met Gln Arg 
            420                 425                 430         


Arg Pro Ser Asn Asp Cys Arg Asn Tyr Arg Pro Pro Arg Leu Ala Ser 
        435                 440                 445             


Ala Phe Gly Asp Pro His Phe Val Thr Phe Asp Gly Thr Asn Phe Thr 
    450                 455                 460                 


Phe Asn Gly Arg Gly Glu Tyr Val Leu Leu Glu Ala Ala Leu Thr Asp 
465                 470                 475                 480 


Leu Arg Val Gln Ala Arg Ala Gln Pro Gly Thr Met Ser Asn Gly Thr 
                485                 490                 495     


Glu Thr Arg Gly Thr Gly Leu Thr Ala Val Ala Val Gln Glu Gly Asn 
            500                 505                 510         


Ser Asp Val Val Glu Val Arg Leu Ala Asn Arg Thr Gly Gly Leu Glu 
        515                 520                 525             


Val Leu Leu Asn Gln Glu Val Leu Ser Phe Thr Glu Gln Ser Trp Met 
    530                 535                 540                 


Asp Leu Lys Gly Met Phe Leu Ser Val Ala Ala Gly Asp Arg Val Ser 
545                 550                 555                 560 


Ile Met Leu Ala Ser Gly Ala Gly Leu Glu Val Ser Val Gln Gly Pro 
                565                 570                 575     


Phe Leu Ser Val Ser Val Leu Leu Pro Glu Lys Phe Leu Thr His Thr 
            580                 585                 590         


His Gly Leu Leu Gly Thr Leu Asn Asn Asp Pro Thr Asp Asp Phe Thr 
        595                 600                 605             


Leu His Ser Gly Arg Val Leu Pro Pro Gly Thr Ser Pro Gln Glu Leu 
    610                 615                 620                 


Phe Leu Phe Gly Ala Asn Trp Thr Val His Asn Ala Ser Ser Leu Leu 
625                 630                 635                 640 


Thr Tyr Asp Ser Trp Phe Leu Val His Asn Phe Leu Tyr Gln Pro Lys 
                645                 650                 655     


His Asp Pro Thr Phe Glu Pro Leu Phe Pro Ser Glu Thr Thr Leu Asn 
            660                 665                 670         


Pro Ser Leu Ala Gln Glu Ala Ala Lys Leu Cys Gly Asp Asp His Phe 
        675                 680                 685             


Cys Asn Phe Asp Val Ala Ala Thr Gly Ser Leu Ser Thr Gly Thr Ala 
    690                 695                 700                 


Thr Arg Val Ala His Gln Leu His Gln Arg Arg Met Gln Ser Leu Gln 
705                 710                 715                 720 


Pro Val Val Ser Cys Gly Trp Leu Ala Pro Pro Pro Asn Gly Gln Lys 
                725                 730                 735     


Glu Gly Asn Arg Tyr Leu Ala Gly Ser Thr Ile Tyr Phe His Cys Asp 
            740                 745                 750         


Asn Gly Tyr Ser Leu Ala Gly Ala Glu Thr Ser Thr Cys Gln Ala Asp 
        755                 760                 765             


Gly Thr Trp Ser Ser Pro Thr Pro Lys Cys Gln Pro Gly Arg Ser Tyr 
    770                 775                 780                 


Ala Val Leu Leu Gly Ile Ile Phe Gly Gly Leu Ala Val Val Ala Ala 
785                 790                 795                 800 


Val Ala Leu Val Tyr Val Leu Leu Arg Arg Arg Lys Gly Asn Thr His 
                805                 810                 815     


Val Trp Gly Ala Gln Pro 
            820         


<210>  4576
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  4576

Met Leu Ala Tyr Ser Ser Val His Cys Phe Arg Glu Asp Lys Met Lys 
1               5                   10                  15      


Phe Thr Ile Val Phe Ala Gly Leu Leu Gly Val Phe Leu Ala Pro Ala 
            20                  25                  30          


Leu Ala Asn Tyr Asn Ile Asn Val Asn Asp Asp Asn Asn Asn Ala Gly 
        35                  40                  45              


Ser Gly Gln Gln Ser Val Ser Val Asn Asn Glu His Asn Val Ala Asn 
    50                  55                  60                  


Val Asp Asn Asn Asn Gly Trp Asp Ser Trp Asn Ser Ile Trp Asp Tyr 
65                  70                  75                  80  


Gly Asn Gly Phe Ala Ala Thr Arg Leu Phe Gln Lys Lys Thr Cys Ile 
                85                  90                  95      


Val His Lys Met Asn Lys Glu Val Met Pro Ser Ile Gln Ser Leu Asp 
            100                 105                 110         


Ala Leu Val Lys Glu Lys Lys Leu Gln Gly Lys Gly Pro Gly Gly Pro 
        115                 120                 125             


Pro Pro Lys Gly Leu Met Tyr Ser Val Asn Pro Asn Lys Val Asp Asp 
    130                 135                 140                 


Leu Ser Lys Phe Gly Lys Asn Ile Ala Asn Met Cys Arg Gly Ile Pro 
145                 150                 155                 160 


Thr Tyr Met Ala Glu Glu Met Gln Glu Ala Ser Leu Phe Phe Tyr Ser 
                165                 170                 175     


Gly Thr Cys Tyr Thr Thr Ser Val Leu Trp Ile Val Asp Ile Ser Phe 
            180                 185                 190         


Cys Gly Asp Thr Val Glu Asn 
        195                 


<210>  4577
<211>  1356
<212>  PRT
<213>  Homo sapiens

<400>  4577

Met Lys Val Thr Val Cys Phe Gly Arg Thr Arg Val Val Val Pro Cys 
1               5                   10                  15      


Gly Asp Gly His Met Lys Val Phe Ser Leu Ile Gln Gln Ala Val Thr 
            20                  25                  30          


Arg Tyr Arg Lys Ala Ile Ala Lys Asp Pro Asn Tyr Trp Ile Gln Val 
        35                  40                  45              


His Arg Leu Glu His Gly Asp Gly Gly Ile Leu Asp Leu Asp Asp Ile 
    50                  55                  60                  


Leu Cys Asp Val Ala Asp Asp Lys Asp Arg Leu Val Ala Val Phe Asp 
65                  70                  75                  80  


Glu Gln Asp Pro His His Gly Gly Asp Gly Thr Ser Ala Ser Ser Thr 
                85                  90                  95      


Gly Thr Gln Ser Pro Glu Ile Phe Gly Ser Glu Leu Gly Thr Asn Asn 
            100                 105                 110         


Val Ser Ala Phe Gln Pro Tyr Gln Ala Thr Ser Glu Ile Glu Val Thr 
        115                 120                 125             


Pro Ser Val Leu Arg Ala Asn Met Pro Leu His Val Arg Arg Ser Ser 
    130                 135                 140                 


Asp Pro Ala Leu Ile Gly Leu Ser Thr Ser Val Ser Asp Ser Asn Phe 
145                 150                 155                 160 


Ser Ser Glu Glu Pro Ser Arg Lys Asn Pro Thr Arg Trp Ser Thr Thr 
                165                 170                 175     


Ala Gly Phe Leu Lys Gln Asn Thr Ala Gly Ser Pro Lys Thr Cys Asp 
            180                 185                 190         


Arg Lys Lys Asp Glu Asn Tyr Arg Ser Leu Pro Arg Asp Thr Ser Asn 
        195                 200                 205             


Trp Ser Asn Gln Phe Gln Arg Asp Asn Ala Arg Ser Ser Leu Ser Ala 
    210                 215                 220                 


Ser His Pro Met Val Gly Lys Trp Leu Glu Lys Gln Glu Gln Asp Glu 
225                 230                 235                 240 


Asp Gly Thr Glu Glu Asp Asn Ser Arg Val Glu Pro Val Gly His Ala 
                245                 250                 255     


Asp Thr Gly Leu Glu His Ile Pro Asn Phe Ser Leu Asp Asp Met Val 
            260                 265                 270         


Lys Leu Val Glu Val Pro Asn Asp Gly Gly Pro Leu Gly Ile His Val 
        275                 280                 285             


Val Pro Phe Ser Ala Arg Gly Gly Arg Thr Leu Gly Leu Leu Val Lys 
    290                 295                 300                 


Arg Leu Glu Lys Gly Gly Lys Ala Glu His Glu Asn Leu Phe Arg Glu 
305                 310                 315                 320 


Asn Asp Cys Ile Val Arg Ile Asn Asp Gly Asp Leu Arg Asn Arg Arg 
                325                 330                 335     


Phe Glu Gln Ala Gln His Met Phe Arg Gln Ala Met Arg Thr Pro Ile 
            340                 345                 350         


Ile Trp Phe His Val Val Pro Ala Ala Asn Lys Glu Gln Tyr Glu Gln 
        355                 360                 365             


Leu Ser Gln Ser Glu Lys Asn Asn Tyr Tyr Ser Ser Arg Phe Ser Pro 
    370                 375                 380                 


Asp Ser Gln Tyr Ile Asp Asn Arg Ser Val Asn Ser Ala Gly Leu His 
385                 390                 395                 400 


Thr Val Gln Arg Ala Pro Arg Leu Asn His Pro Pro Glu Gln Ile Asp 
                405                 410                 415     


Ser His Ser Arg Leu Pro His Ser Ala His Pro Ser Gly Lys Pro Pro 
            420                 425                 430         


Ser Ala Pro Ala Ser Ala Pro Gln Asn Val Phe Ser Thr Thr Val Ser 
        435                 440                 445             


Ser Gly Tyr Asn Thr Lys Lys Ile Gly Lys Arg Leu Asn Ile Gln Leu 
    450                 455                 460                 


Lys Lys Gly Thr Glu Gly Leu Gly Phe Ser Ile Thr Ser Arg Asp Val 
465                 470                 475                 480 


Thr Ile Gly Gly Ser Ala Pro Ile Tyr Val Lys Asn Ile Leu Pro Arg 
                485                 490                 495     


Gly Ala Ala Ile Gln Asp Gly Arg Leu Lys Ala Gly Asp Arg Leu Ile 
            500                 505                 510         


Glu Val Asn Gly Val Asp Leu Val Gly Lys Ser Gln Glu Glu Val Val 
        515                 520                 525             


Ser Leu Leu Arg Ser Thr Lys Met Glu Gly Thr Val Ser Leu Leu Val 
    530                 535                 540                 


Phe Arg Gln Glu Asp Ala Phe His Pro Arg Glu Leu Asn Ala Glu Pro 
545                 550                 555                 560 


Ser Gln Met Gln Ile Pro Lys Glu Thr Lys Ala Glu Asp Glu Asp Ile 
                565                 570                 575     


Val Leu Thr Pro Asp Gly Thr Arg Glu Phe Leu Thr Phe Glu Val Pro 
            580                 585                 590         


Leu Asn Asp Ser Gly Ser Ala Gly Leu Gly Val Ser Val Lys Gly Asn 
        595                 600                 605             


Arg Ser Lys Glu Asn His Ala Asp Leu Gly Ile Phe Val Lys Ser Ile 
    610                 615                 620                 


Ile Asn Gly Gly Ala Ala Ser Lys Asp Gly Arg Leu Arg Val Asn Asp 
625                 630                 635                 640 


Gln Leu Ile Ala Val Asn Gly Glu Ser Leu Leu Gly Lys Thr Asn Gln 
                645                 650                 655     


Asp Ala Met Glu Thr Leu Arg Arg Ser Met Ser Thr Glu Gly Asn Lys 
            660                 665                 670         


Arg Gly Met Ile Gln Leu Ile Val Ala Arg Arg Ile Ser Lys Cys Asn 
        675                 680                 685             


Glu Leu Lys Ser Pro Gly Ser Pro Pro Gly Pro Glu Leu Pro Ile Glu 
    690                 695                 700                 


Thr Ala Leu Asp Asp Arg Glu Arg Arg Ile Ser His Ser Leu Tyr Ser 
705                 710                 715                 720 


Gly Ile Glu Gly Leu Asp Glu Ser Pro Ser Arg Asn Ala Ala Leu Ser 
                725                 730                 735     


Arg Ile Met Gly Glu Ser Gly Lys Tyr Gln Leu Ser Pro Thr Val Asn 
            740                 745                 750         


Met Pro Gln Asp Asp Thr Val Ile Ile Glu Asp Asp Arg Leu Pro Val 
        755                 760                 765             


Leu Pro Pro His Leu Ser Asp Gln Ser Ser Ser Ser Ser His Asp Asp 
    770                 775                 780                 


Val Gly Phe Val Thr Ala Asp Ala Gly Thr Trp Ala Lys Ala Ala Ile 
785                 790                 795                 800 


Ser Asp Ser Ala Asp Cys Ser Leu Ser Pro Asp Val Asp Pro Val Leu 
                805                 810                 815     


Ala Phe Gln Arg Glu Gly Phe Gly Arg Gln Ser Met Ser Glu Lys Arg 
            820                 825                 830         


Thr Lys Gln Phe Ser Asp Ala Ser Gln Leu Asp Phe Val Lys Thr Arg 
        835                 840                 845             


Lys Ser Lys Ser Met Asp Leu Gly Ile Ala Asp Glu Thr Lys Leu Asn 
    850                 855                 860                 


Thr Val Asp Asp Gln Lys Ala Gly Ser Pro Ser Arg Asp Val Gly Pro 
865                 870                 875                 880 


Ser Leu Gly Leu Lys Lys Ser Ser Ser Leu Glu Ser Leu Gln Thr Ala 
                885                 890                 895     


Val Ala Glu Val Thr Leu Asn Gly Asp Ile Pro Phe His Arg Pro Arg 
            900                 905                 910         


Pro Arg Ile Ile Arg Gly Arg Gly Cys Asn Glu Ser Phe Arg Ala Ala 
        915                 920                 925             


Ile Asp Lys Ser Tyr Asp Lys Pro Ala Val Asp Asp Asp Asp Glu Gly 
    930                 935                 940                 


Met Glu Thr Leu Glu Glu Asp Thr Glu Glu Ser Ser Arg Ser Gly Arg 
945                 950                 955                 960 


Glu Ser Val Ser Thr Ala Ser Asp Gln Pro Ser His Ser Leu Glu Arg 
                965                 970                 975     


Gln Met Asn Gly Asn Gln Glu Lys Gly Asp Lys Thr Asp Arg Lys Lys 
            980                 985                 990         


Asp Lys Thr Gly Lys Glu Lys Lys  Lys Asp Arg Asp Lys  Glu Lys Asp 
        995                 1000                 1005             


Lys Met  Lys Ala Lys Lys Gly  Met Leu Lys Gly Leu  Gly Asp Met 
    1010                 1015                 1020             


Phe Arg  Phe Gly Lys His Arg  Lys Asp Asp Lys Ile  Glu Lys Thr 
    1025                 1030                 1035             


Gly Lys  Ile Lys Ile Gln Glu  Ser Phe Thr Ser Glu  Glu Glu Arg 
    1040                 1045                 1050             


Ile Arg  Met Lys Gln Glu Gln  Glu Arg Ile Gln Ala  Lys Thr Arg 
    1055                 1060                 1065             


Glu Phe  Arg Glu Arg Gln Ala  Arg Glu Arg Asp Tyr  Ala Glu Ile 
    1070                 1075                 1080             


Gln Asp  Phe His Arg Thr Phe  Gly Cys Asp Asp Glu  Leu Met Tyr 
    1085                 1090                 1095             


Gly Gly  Val Ser Ser Tyr Glu  Gly Ser Met Ala Leu  Asn Ala Arg 
    1100                 1105                 1110             


Pro Gln  Ser Pro Arg Glu Gly  His Met Met Asp Ala  Leu Tyr Ala 
    1115                 1120                 1125             


Gln Val  Lys Lys Pro Arg Asn  Ser Lys Pro Ser Pro  Val Asp Ser 
    1130                 1135                 1140             


Asn Arg  Ser Thr Pro Ser Asn  His Asp Arg Ile Gln  Arg Leu Arg 
    1145                 1150                 1155             


Gln Glu  Phe Gln Gln Ala Lys  Gln Asp Glu Asp Val  Glu Asp Arg 
    1160                 1165                 1170             


Arg Arg  Thr Tyr Ser Phe Glu  Gln Pro Trp Pro Asn  Ala Arg Pro 
    1175                 1180                 1185             


Ala Thr  Gln Ser Gly Arg His  Ser Val Ser Val Glu  Val Gln Met 
    1190                 1195                 1200             


Gln Arg  Gln Arg Gln Glu Glu  Arg Glu Ser Ser Gln  Gln Ala Gln 
    1205                 1210                 1215             


Arg Gln  Tyr Ser Ser Leu Pro  Arg Gln Ser Arg Lys  Asn Ala Ser 
    1220                 1225                 1230             


Ser Val  Ser Gln Asp Ser Trp  Glu Gln Asn Tyr Ser  Pro Gly Glu 
    1235                 1240                 1245             


Gly Phe  Gln Ser Ala Lys Glu  Asn Pro Arg Tyr Ser  Ser Tyr Gln 
    1250                 1255                 1260             


Gly Ser  Arg Asn Gly Tyr Leu  Gly Gly His Gly Phe  Asn Ala Arg 
    1265                 1270                 1275             


Val Met  Leu Glu Thr Gln Glu  Leu Leu Arg Gln Glu  Gln Arg Arg 
    1280                 1285                 1290             


Lys Glu  Gln Gln Met Lys Lys  Gln Pro Pro Ser Glu  Gly Pro Ser 
    1295                 1300                 1305             


Asn Tyr  Asp Ser Tyr Lys Lys  Val Gln Asp Pro Ser  Tyr Ala Pro 
    1310                 1315                 1320             


Pro Lys  Gly Pro Phe Arg Gln  Asp Val Pro Pro Ser  Pro Ser Gln 
    1325                 1330                 1335             


Val Ala  Arg Leu Asn Arg Leu  Gln Thr Pro Glu Lys  Gly Arg Pro 
    1340                 1345                 1350             


Phe Tyr  Ser 
    1355     


<210>  4578
<211>  723
<212>  PRT
<213>  Homo sapiens

<400>  4578

Met Arg Leu Trp Lys Ala Val Val Val Thr Leu Ala Phe Met Ser Val 
1               5                   10                  15      


Asp Ile Cys Val Thr Thr Ala Ile Tyr Val Phe Ser His Leu Asp Arg 
            20                  25                  30          


Ser Leu Leu Glu Asp Ile Arg His Phe Asn Ile Phe Asp Ser Val Leu 
        35                  40                  45              


Asp Leu Trp Ala Ala Cys Leu Tyr Arg Ser Cys Leu Leu Leu Gly Ala 
    50                  55                  60                  


Thr Ile Gly Val Ala Lys Asn Ser Ala Leu Gly Pro Arg Arg Leu Arg 
65                  70                  75                  80  


Ala Ser Trp Leu Val Ile Thr Leu Val Cys Leu Phe Val Gly Ile Tyr 
                85                  90                  95      


Ala Met Val Lys Leu Leu Leu Phe Ser Glu Val Arg Arg Pro Ile Arg 
            100                 105                 110         


Asp Pro Trp Phe Trp Ala Leu Phe Val Trp Thr Tyr Ile Ser Leu Gly 
        115                 120                 125             


Ala Ser Phe Leu Leu Trp Trp Leu Leu Ser Thr Val Arg Pro Gly Thr 
    130                 135                 140                 


Gln Ala Leu Glu Pro Gly Ala Ala Thr Glu Ala Glu Gly Phe Pro Gly 
145                 150                 155                 160 


Ser Gly Arg Pro Pro Pro Glu Gln Ala Ser Gly Ala Thr Leu Gln Lys 
                165                 170                 175     


Leu Leu Ser Tyr Thr Lys Pro Asp Val Ala Phe Leu Val Ala Ala Ser 
            180                 185                 190         


Phe Phe Leu Ile Val Ala Ala Leu Gly Glu Thr Phe Leu Pro Tyr Tyr 
        195                 200                 205             


Thr Gly Arg Ala Ile Asp Gly Ile Val Ile Gln Lys Ser Met Asp Gln 
    210                 215                 220                 


Phe Ser Thr Ala Val Val Ile Val Cys Leu Leu Ala Ile Gly Ser Ser 
225                 230                 235                 240 


Phe Ala Ala Gly Ile Arg Gly Gly Ile Phe Thr Leu Ile Phe Ala Arg 
                245                 250                 255     


Leu Asn Ile Arg Leu Arg Asn Cys Leu Phe Arg Ser Leu Val Ser Gln 
            260                 265                 270         


Glu Thr Ser Phe Phe Asp Glu Asn Arg Thr Gly Asp Leu Ile Ser Arg 
        275                 280                 285             


Leu Thr Ser Asp Thr Thr Met Val Ser Asp Leu Val Ser Gln Asn Ile 
    290                 295                 300                 


Asn Val Phe Leu Arg Asn Thr Val Lys Val Thr Gly Val Val Val Phe 
305                 310                 315                 320 


Met Phe Ser Leu Ser Trp Gln Leu Ser Leu Val Thr Phe Met Gly Phe 
                325                 330                 335     


Pro Ile Ile Met Met Val Ser Asn Ile Tyr Gly Lys Tyr Tyr Lys Arg 
            340                 345                 350         


Leu Ser Lys Glu Val Gln Asn Ala Leu Ala Arg Ala Ser Asn Thr Ala 
        355                 360                 365             


Glu Glu Thr Ile Ser Ala Met Lys Thr Val Arg Ser Phe Ala Asn Glu 
    370                 375                 380                 


Glu Glu Glu Ala Glu Val Tyr Leu Arg Lys Leu Gln Gln Val Tyr Lys 
385                 390                 395                 400 


Leu Asn Arg Lys Glu Ala Ala Ala Tyr Met Tyr Tyr Val Trp Gly Ser 
                405                 410                 415     


Gly Ser Val Gly Ser Val Tyr Ser Gly Leu Met Gln Gly Val Gly Ala 
            420                 425                 430         


Ala Glu Lys Val Phe Glu Phe Ile Asp Arg Gln Pro Thr Met Val His 
        435                 440                 445             


Asp Gly Ser Leu Ala Pro Asp His Leu Glu Gly Arg Val Asp Phe Glu 
    450                 455                 460                 


Asn Val Thr Phe Thr Tyr Arg Thr Arg Pro His Thr Gln Val Leu Gln 
465                 470                 475                 480 


Asn Val Ser Phe Ser Leu Ser Pro Gly Lys Val Thr Ala Leu Val Gly 
                485                 490                 495     


Pro Ser Gly Ser Gly Lys Ser Ser Cys Val Asn Ile Leu Glu Asn Phe 
            500                 505                 510         


Tyr Pro Leu Glu Gly Gly Arg Val Leu Leu Asp Gly Lys Pro Ile Ser 
        515                 520                 525             


Ala Tyr Asp His Lys Tyr Leu His Arg Val Ile Ser Leu Val Ser Gln 
    530                 535                 540                 


Glu Pro Val Leu Phe Ala Arg Ser Ile Thr Asp Asn Ile Ser Tyr Gly 
545                 550                 555                 560 


Leu Pro Thr Val Pro Phe Glu Met Val Val Glu Ala Ala Gln Lys Ala 
                565                 570                 575     


Asn Ala His Gly Phe Ile Met Glu Leu Gln Asp Gly Tyr Ser Thr Glu 
            580                 585                 590         


Thr Gly Glu Lys Gly Ala Gln Leu Ser Gly Gly Gln Lys Gln Arg Val 
        595                 600                 605             


Ala Met Ala Arg Ala Leu Val Arg Asn Pro Pro Val Leu Ile Leu Asp 
    610                 615                 620                 


Glu Ala Thr Ser Ala Leu Asp Ala Glu Ser Glu Tyr Leu Ile Gln Gln 
625                 630                 635                 640 


Ala Ile His Gly Asn Leu Gln Lys His Thr Val Leu Ile Ile Ala His 
                645                 650                 655     


Arg Leu Ser Thr Val Glu His Ala His Leu Ile Val Val Leu Asp Lys 
            660                 665                 670         


Gly Arg Val Val Gln Gln Gly Thr His Gln Gln Leu Leu Ala Gln Gly 
        675                 680                 685             


Gly Leu Tyr Ala Lys Leu Val Gln Arg Gln Met Leu Gly Leu Gln Pro 
    690                 695                 700                 


Ala Ala Asp Phe Thr Ala Gly His Asn Glu Pro Val Ala Asn Gly Ser 
705                 710                 715                 720 


His Lys Ala 
            


<210>  4579
<211>  766
<212>  PRT
<213>  Homo sapiens

<400>  4579

Met Arg Leu Trp Lys Ala Val Val Val Thr Leu Ala Phe Met Ser Val 
1               5                   10                  15      


Asp Ile Cys Val Thr Thr Ala Ile Tyr Val Phe Ser His Leu Asp Arg 
            20                  25                  30          


Ser Leu Leu Glu Asp Ile Arg His Phe Asn Ile Phe Asp Ser Val Leu 
        35                  40                  45              


Asp Leu Trp Ala Ala Cys Leu Tyr Arg Ser Cys Leu Leu Leu Gly Ala 
    50                  55                  60                  


Thr Ile Gly Val Ala Lys Asn Ser Ala Leu Gly Pro Arg Arg Leu Arg 
65                  70                  75                  80  


Ala Ser Trp Leu Val Ile Thr Leu Val Cys Leu Phe Val Gly Ile Tyr 
                85                  90                  95      


Ala Met Val Lys Leu Leu Leu Phe Ser Glu Val Arg Arg Pro Ile Arg 
            100                 105                 110         


Asp Pro Trp Phe Trp Ala Leu Phe Val Trp Thr Tyr Ile Ser Leu Gly 
        115                 120                 125             


Ala Ser Phe Leu Leu Trp Trp Leu Leu Ser Thr Val Arg Pro Gly Thr 
    130                 135                 140                 


Gln Ala Leu Glu Pro Gly Ala Ala Thr Glu Ala Glu Gly Phe Pro Gly 
145                 150                 155                 160 


Ser Gly Arg Pro Pro Pro Glu Gln Ala Ser Gly Ala Thr Leu Gln Lys 
                165                 170                 175     


Leu Leu Ser Tyr Thr Lys Pro Asp Val Ala Phe Leu Val Ala Ala Ser 
            180                 185                 190         


Phe Phe Leu Ile Val Ala Ala Leu Gly Glu Thr Phe Leu Pro Tyr Tyr 
        195                 200                 205             


Thr Gly Arg Ala Ile Asp Gly Ile Val Ile Gln Lys Ser Met Asp Gln 
    210                 215                 220                 


Phe Ser Thr Ala Val Val Ile Val Cys Leu Leu Ala Ile Gly Ser Ser 
225                 230                 235                 240 


Phe Ala Ala Gly Ile Arg Gly Gly Ile Phe Thr Leu Ile Phe Ala Arg 
                245                 250                 255     


Leu Asn Ile Arg Leu Arg Asn Cys Leu Phe Arg Ser Leu Val Ser Gln 
            260                 265                 270         


Glu Thr Ser Phe Phe Asp Glu Asn Arg Thr Gly Asp Leu Ile Ser Arg 
        275                 280                 285             


Leu Thr Ser Asp Thr Thr Met Val Ser Asp Leu Val Ser Gln Asn Ile 
    290                 295                 300                 


Asn Val Phe Leu Arg Asn Thr Val Lys Val Thr Gly Val Val Val Phe 
305                 310                 315                 320 


Met Phe Ser Leu Ser Trp Gln Leu Ser Leu Val Thr Phe Met Gly Phe 
                325                 330                 335     


Pro Ile Ile Met Met Val Ser Asn Ile Tyr Gly Lys Tyr Tyr Lys Arg 
            340                 345                 350         


Leu Ser Lys Glu Val Gln Asn Ala Leu Ala Arg Ala Ser Asn Thr Ala 
        355                 360                 365             


Glu Glu Thr Ile Ser Ala Met Lys Thr Val Arg Ser Phe Ala Asn Glu 
    370                 375                 380                 


Glu Glu Glu Ala Glu Val Tyr Leu Arg Lys Leu Gln Gln Val Tyr Lys 
385                 390                 395                 400 


Leu Asn Arg Lys Glu Ala Ala Ala Tyr Met Tyr Tyr Val Trp Gly Ser 
                405                 410                 415     


Gly Leu Thr Leu Leu Val Val Gln Val Ser Ile Leu Tyr Tyr Gly Gly 
            420                 425                 430         


His Leu Val Ile Ser Gly Gln Met Thr Ser Gly Asn Leu Ile Ala Phe 
        435                 440                 445             


Ile Ile Tyr Glu Phe Val Leu Gly Asp Cys Met Glu Ser Val Gly Ser 
    450                 455                 460                 


Val Tyr Ser Gly Leu Met Gln Gly Val Gly Ala Ala Glu Lys Val Phe 
465                 470                 475                 480 


Glu Phe Ile Asp Arg Gln Pro Thr Met Val His Asp Gly Ser Leu Ala 
                485                 490                 495     


Pro Asp His Leu Glu Gly Arg Val Asp Phe Glu Asn Val Thr Phe Thr 
            500                 505                 510         


Tyr Arg Thr Arg Pro His Thr Gln Val Leu Gln Asn Val Ser Phe Ser 
        515                 520                 525             


Leu Ser Pro Gly Lys Val Thr Ala Leu Val Gly Pro Ser Gly Ser Gly 
    530                 535                 540                 


Lys Ser Ser Cys Val Asn Ile Leu Glu Asn Phe Tyr Pro Leu Glu Gly 
545                 550                 555                 560 


Gly Arg Val Leu Leu Asp Gly Lys Pro Ile Ser Ala Tyr Asp His Lys 
                565                 570                 575     


Tyr Leu His Arg Val Ile Ser Leu Val Ser Gln Glu Pro Val Leu Phe 
            580                 585                 590         


Ala Arg Ser Ile Thr Asp Asn Ile Ser Tyr Gly Leu Pro Thr Val Pro 
        595                 600                 605             


Phe Glu Met Val Val Glu Ala Ala Gln Lys Ala Asn Ala His Gly Phe 
    610                 615                 620                 


Ile Met Glu Leu Gln Asp Gly Tyr Ser Thr Glu Thr Gly Glu Lys Gly 
625                 630                 635                 640 


Ala Gln Leu Ser Gly Gly Gln Lys Gln Arg Val Ala Met Ala Arg Ala 
                645                 650                 655     


Leu Val Arg Asn Pro Pro Val Leu Ile Leu Asp Glu Ala Thr Ser Ala 
            660                 665                 670         


Leu Asp Ala Glu Ser Glu Tyr Leu Ile Gln Gln Ala Ile His Gly Asn 
        675                 680                 685             


Leu Gln Lys His Thr Val Leu Ile Ile Ala His Arg Leu Ser Thr Val 
    690                 695                 700                 


Glu His Ala His Leu Ile Val Val Leu Asp Lys Gly Arg Val Val Gln 
705                 710                 715                 720 


Gln Gly Thr His Gln Gln Leu Leu Ala Gln Gly Gly Leu Tyr Ala Lys 
                725                 730                 735     


Leu Val Gln Arg Gln Met Leu Gly Leu Gln Pro Ala Ala Asp Phe Thr 
            740                 745                 750         


Ala Gly His Asn Glu Pro Val Ala Asn Gly Ser His Lys Ala 
        755                 760                 765     


<210>  4580
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  4580

Met Ser Val Cys Tyr Arg Pro Pro Gly Asn Glu Thr Leu Leu Ser Trp 
1               5                   10                  15      


Lys Thr Ser Arg Ala Thr Gly Thr Ala Phe Leu Leu Leu Ala Ala Leu 
            20                  25                  30          


Leu Gly Leu Pro Gly Asn Gly Phe Val Val Trp Ser Leu Ala Gly Trp 
        35                  40                  45              


Arg Pro Ala Arg Gly Arg Pro Leu Ala Ala Thr Leu Val Leu His Leu 
    50                  55                  60                  


Ala Leu Ala Asp Gly Ala Val Leu Leu Leu Thr Pro Leu Phe Val Ala 
65                  70                  75                  80  


Phe Leu Thr Arg Gln Ala Trp Pro Leu Gly Gln Ala Gly Cys Lys Ala 
                85                  90                  95      


Val Tyr Tyr Val Cys Ala Leu Ser Met Tyr Ala Ser Val Leu Leu Thr 
            100                 105                 110         


Gly Leu Leu Ser Leu Gln Arg Cys Leu Ala Val Thr Arg Pro Phe Leu 
        115                 120                 125             


Ala Pro Arg Leu Arg Ser Pro Ala Leu Ala Arg Arg Leu Leu Leu Ala 
    130                 135                 140                 


Val Trp Leu Ala Ala Leu Leu Leu Ala Val Pro Ala Ala Val Tyr Arg 
145                 150                 155                 160 


His Leu Trp Arg Asp Arg Val Cys Gln Leu Cys His Pro Ser Pro Val 
                165                 170                 175     


His Ala Ala Ala His Leu Ser Leu Glu Thr Leu Thr Ala Phe Val Leu 
            180                 185                 190         


Pro Phe Gly Leu Met Leu Gly Cys Tyr Ser Val Thr Leu Ala Arg Leu 
        195                 200                 205             


Arg Gly Ala Arg Trp Gly Ser Gly Arg His Gly Ala Arg Val Gly Arg 
    210                 215                 220                 


Leu Val Ser Ala Ile Val Leu Ala Phe Gly Leu Leu Trp Ala Pro Tyr 
225                 230                 235                 240 


His Ala Val Asn Leu Leu Gln Ala Val Ala Ala Leu Ala Pro Pro Glu 
                245                 250                 255     


Gly Ala Leu Ala Lys Leu Gly Gly Ala Gly Gln Ala Ala Arg Ala Gly 
            260                 265                 270         


Thr Thr Ala Leu Ala Phe Phe Ser Ser Ser Val Asn Pro Val Leu Tyr 
        275                 280                 285             


Val Phe Thr Ala Gly Asp Leu Leu Pro Arg Ala Gly Pro Arg Phe Leu 
    290                 295                 300                 


Thr Arg Leu Phe Glu Gly Ser Gly Glu Ala Arg Gly Gly Gly Arg Ser 
305                 310                 315                 320 


Arg Glu Gly Thr Met Glu Leu Arg Thr Thr Pro Gln Leu Lys Val Val 
                325                 330                 335     


Gly Gln Gly Arg Gly Asn Gly Asp Pro Gly Gly Gly Met Glu Lys Asp 
            340                 345                 350         


Gly Pro Glu Trp Asp Leu 
        355             


<210>  4581
<211>  729
<212>  PRT
<213>  Homo sapiens

<400>  4581

Met Gly Gly Phe Leu Pro Lys Ala Glu Gly Pro Gly Ser Gln Leu Gln 
1               5                   10                  15      


Lys Leu Leu Pro Ser Phe Leu Val Arg Glu Gln Asp Trp Asp Gln His 
            20                  25                  30          


Leu Asp Lys Leu His Met Leu Gln Gln Lys Arg Ile Leu Glu Ser Pro 
        35                  40                  45              


Leu Leu Arg Ala Ser Lys Glu Asn Asp Leu Ser Val Leu Arg Gln Leu 
    50                  55                  60                  


Leu Leu Asp Cys Thr Cys Asp Val Arg Gln Arg Gly Ala Leu Gly Glu 
65                  70                  75                  80  


Thr Ala Leu His Ile Ala Ala Leu Tyr Asp Asn Leu Glu Ala Ala Leu 
                85                  90                  95      


Val Leu Met Glu Ala Ala Pro Glu Leu Val Phe Glu Pro Thr Thr Cys 
            100                 105                 110         


Glu Ala Phe Ala Gly Gln Thr Ala Leu His Ile Ala Val Val Asn Gln 
        115                 120                 125             


Asn Val Asn Leu Val Arg Ala Leu Leu Thr Arg Arg Ala Ser Val Ser 
    130                 135                 140                 


Ala Arg Ala Thr Gly Thr Ala Phe Arg His Ser Pro Arg Asn Leu Ile 
145                 150                 155                 160 


Tyr Phe Gly Glu His Pro Leu Ser Phe Ala Ala Cys Val Asn Ser Glu 
                165                 170                 175     


Glu Ile Val Arg Leu Leu Ile Glu His Gly Ala Asp Ile Arg Ala Gln 
            180                 185                 190         


Asp Ser Leu Gly Asn Thr Val Leu His Ile Leu Ile Leu Gln Pro Asn 
        195                 200                 205             


Lys Thr Phe Ala Cys Gln Met Tyr Asn Leu Leu Leu Ser Tyr Asp Gly 
    210                 215                 220                 


His Gly Asp His Leu Gln Pro Leu Asp Leu Val Pro Asn His Gln Gly 
225                 230                 235                 240 


Leu Thr Pro Phe Lys Leu Ala Gly Val Glu Gly Asn Thr Val Met Phe 
                245                 250                 255     


Gln His Leu Met Gln Lys Arg Arg His Ile Gln Trp Thr Tyr Gly Pro 
            260                 265                 270         


Leu Thr Ser Ile Leu Tyr Asp Leu Thr Glu Ile Asp Ser Trp Gly Glu 
        275                 280                 285             


Glu Leu Ser Phe Leu Glu Leu Val Val Ser Ser Asp Lys Arg Glu Ala 
    290                 295                 300                 


Arg Gln Ile Leu Glu Gln Thr Pro Val Lys Glu Leu Val Ser Phe Lys 
305                 310                 315                 320 


Trp Asn Lys Tyr Gly Arg Pro Tyr Phe Cys Ile Leu Ala Ala Leu Tyr 
                325                 330                 335     


Leu Leu Tyr Met Ile Cys Phe Thr Thr Cys Cys Val Tyr Arg Pro Leu 
            340                 345                 350         


Lys Phe Arg Gly Gly Asn Arg Thr His Ser Arg Asp Ile Thr Ile Leu 
        355                 360                 365             


Gln Gln Lys Leu Leu Gln Glu Ala Tyr Glu Thr Arg Glu Asp Ile Ile 
    370                 375                 380                 


Arg Leu Val Gly Glu Leu Val Ser Ile Val Gly Ala Val Ile Ile Leu 
385                 390                 395                 400 


Leu Leu Glu Ile Pro Asp Ile Phe Arg Val Gly Ala Ser Arg Tyr Phe 
                405                 410                 415     


Gly Lys Thr Ile Leu Gly Gly Pro Phe His Val Ile Ile Ile Thr Tyr 
            420                 425                 430         


Ala Ser Leu Val Leu Val Thr Met Val Met Arg Leu Thr Asn Thr Asn 
        435                 440                 445             


Gly Glu Val Val Pro Met Ser Phe Ala Leu Val Leu Gly Trp Cys Ser 
    450                 455                 460                 


Val Met Tyr Phe Thr Arg Gly Phe Gln Met Leu Gly Pro Phe Thr Ile 
465                 470                 475                 480 


Met Ile Gln Lys Met Ile Phe Gly Asp Leu Met Arg Phe Cys Trp Leu 
                485                 490                 495     


Met Ala Val Val Ile Leu Gly Phe Ala Ser Ala Phe Tyr Ile Ile Phe 
            500                 505                 510         


Gln Thr Glu Asp Pro Thr Ser Leu Gly Gln Phe Tyr Asp Tyr Pro Met 
        515                 520                 525             


Ala Leu Phe Thr Thr Phe Glu Leu Phe Leu Thr Val Ile Asp Ala Pro 
    530                 535                 540                 


Ala Asn Tyr Asp Val Asp Leu Pro Phe Met Phe Ser Ile Val Asn Phe 
545                 550                 555                 560 


Ala Phe Thr Ile Ile Ala Thr Leu Leu Met Leu Asn Leu Phe Ile Ala 
                565                 570                 575     


Met Met Gly Asp Thr His Trp Arg Val Ala Gln Glu Arg Asp Glu Leu 
            580                 585                 590         


Trp Arg Ala Gln Val Val Ala Thr Thr Val Met Leu Glu Arg Lys Leu 
        595                 600                 605             


Pro Arg Cys Leu Trp Pro Arg Ser Gly Ile Cys Gly Cys Glu Phe Gly 
    610                 615                 620                 


Leu Gly Asp Arg Trp Phe Leu Arg Val Glu Asn His Asn Asp Gln Asn 
625                 630                 635                 640 


Pro Leu Arg Val Leu Arg Tyr Val Glu Val Phe Lys Asn Ser Asp Lys 
                645                 650                 655     


Glu Asp Asp Gln Glu His Pro Ser Glu Lys Gln Pro Ser Gly Ala Glu 
            660                 665                 670         


Ser Gly Thr Leu Ala Arg Ala Ser Leu Ala Leu Pro Thr Ser Ser Leu 
        675                 680                 685             


Ser Arg Thr Ala Ser Gln Ser Ser Ser His Arg Gly Trp Glu Ile Leu 
    690                 695                 700                 


Arg Gln Asn Thr Leu Gly His Leu Asn Leu Gly Leu Asn Leu Ser Glu 
705                 710                 715                 720 


Gly Asp Gly Glu Glu Val Tyr His Phe 
                725                 


<210>  4582
<211>  702
<212>  PRT
<213>  Homo sapiens

<400>  4582

Met Asp Gln His Gln His Leu Asn Lys Thr Ala Glu Ser Ala Ser Ser 
1               5                   10                  15      


Glu Lys Lys Lys Thr Arg Arg Cys Asn Gly Phe Lys Met Phe Leu Ala 
            20                  25                  30          


Ala Leu Ser Phe Ser Tyr Ile Ala Lys Ala Leu Gly Gly Ile Ile Met 
        35                  40                  45              


Lys Ile Ser Ile Thr Gln Ile Glu Arg Arg Phe Asp Ile Ser Ser Ser 
    50                  55                  60                  


Leu Ala Gly Leu Ile Asp Gly Ser Phe Glu Ile Gly Asn Leu Leu Val 
65                  70                  75                  80  


Ile Val Phe Val Ser Tyr Phe Gly Ser Lys Leu His Arg Pro Lys Leu 
                85                  90                  95      


Ile Gly Ile Gly Cys Leu Leu Met Gly Thr Gly Ser Ile Leu Thr Ser 
            100                 105                 110         


Leu Pro His Phe Phe Met Gly Tyr Tyr Arg Tyr Ser Lys Glu Thr His 
        115                 120                 125             


Ile Asn Pro Ser Glu Asn Ser Thr Ser Ser Leu Ser Thr Cys Leu Ile 
    130                 135                 140                 


Asn Gln Thr Leu Ser Phe Asn Gly Thr Ser Pro Glu Ile Val Glu Lys 
145                 150                 155                 160 


Asp Cys Val Lys Glu Ser Gly Ser His Met Trp Ile Tyr Val Phe Met 
                165                 170                 175     


Gly Asn Met Leu Arg Gly Ile Gly Glu Thr Pro Ile Val Pro Leu Gly 
            180                 185                 190         


Ile Ser Tyr Ile Asp Asp Phe Ala Lys Glu Gly His Ser Ser Leu Tyr 
        195                 200                 205             


Leu Gly Ser Leu Asn Ala Ile Gly Met Ile Gly Pro Val Ile Gly Phe 
    210                 215                 220                 


Ala Leu Gly Ser Leu Phe Ala Lys Met Tyr Val Asp Ile Gly Tyr Val 
225                 230                 235                 240 


Asp Leu Ser Thr Ile Arg Ile Thr Pro Lys Asp Ser Arg Trp Val Gly 
                245                 250                 255     


Ala Trp Trp Leu Gly Phe Leu Val Ser Gly Leu Phe Ser Ile Ile Ser 
            260                 265                 270         


Ser Ile Pro Phe Phe Phe Leu Pro Lys Asn Pro Asn Lys Pro Gln Lys 
        275                 280                 285             


Glu Arg Lys Ile Ser Leu Ser Leu His Val Leu Lys Thr Asn Asp Asp 
    290                 295                 300                 


Arg Asn Gln Thr Ala Asn Leu Thr Asn Gln Gly Lys Asn Val Thr Lys 
305                 310                 315                 320 


Asn Val Thr Gly Phe Phe Gln Ser Leu Lys Ser Ile Leu Thr Asn Pro 
                325                 330                 335     


Leu Tyr Val Ile Phe Leu Leu Leu Thr Leu Leu Gln Val Ser Ser Phe 
            340                 345                 350         


Ile Gly Ser Phe Thr Tyr Val Phe Lys Tyr Met Glu Gln Gln Tyr Gly 
        355                 360                 365             


Gln Ser Ala Ser His Ala Asn Phe Leu Leu Gly Ile Ile Thr Ile Pro 
    370                 375                 380                 


Thr Val Ala Thr Gly Met Phe Leu Gly Gly Phe Ile Ile Lys Lys Phe 
385                 390                 395                 400 


Lys Leu Ser Leu Val Gly Ile Ala Lys Phe Ser Phe Leu Thr Ser Met 
                405                 410                 415     


Ile Ser Phe Leu Phe Gln Leu Leu Tyr Phe Pro Leu Ile Cys Glu Ser 
            420                 425                 430         


Lys Ser Val Ala Gly Leu Thr Leu Thr Tyr Asp Gly Asn Asn Ser Val 
        435                 440                 445             


Ala Ser His Val Asp Val Pro Leu Ser Tyr Cys Asn Ser Glu Cys Asn 
    450                 455                 460                 


Cys Asp Glu Ser Gln Trp Glu Pro Val Cys Gly Asn Asn Gly Ile Thr 
465                 470                 475                 480 


Tyr Leu Ser Pro Cys Leu Ala Gly Cys Lys Ser Ser Ser Gly Ile Lys 
                485                 490                 495     


Lys His Thr Val Phe Tyr Asn Cys Ser Cys Val Glu Val Thr Gly Leu 
            500                 505                 510         


Gln Asn Arg Asn Tyr Ser Ala His Leu Gly Glu Cys Pro Arg Asp Asn 
        515                 520                 525             


Thr Cys Thr Arg Lys Phe Phe Ile Tyr Val Ala Ile Gln Val Ile Asn 
    530                 535                 540                 


Ser Leu Phe Ser Ala Thr Gly Gly Thr Thr Phe Ile Leu Leu Thr Val 
545                 550                 555                 560 


Lys Ile Val Gln Pro Glu Leu Lys Ala Leu Ala Met Gly Phe Gln Ser 
                565                 570                 575     


Met Val Ile Arg Thr Leu Gly Gly Ile Leu Ala Pro Ile Tyr Phe Gly 
            580                 585                 590         


Ala Leu Ile Asp Lys Thr Cys Met Lys Trp Ser Thr Asn Ser Cys Gly 
        595                 600                 605             


Ala Gln Gly Ala Cys Arg Ile Tyr Asn Ser Val Phe Phe Gly Arg Val 
    610                 615                 620                 


Tyr Leu Gly Leu Ser Ile Ala Leu Arg Phe Pro Ala Leu Val Leu Tyr 
625                 630                 635                 640 


Ile Val Phe Ile Phe Ala Met Lys Lys Lys Phe Gln Gly Lys Asp Thr 
                645                 650                 655     


Lys Ala Ser Asp Asn Glu Arg Lys Val Met Asp Glu Ala Asn Leu Glu 
            660                 665                 670         


Phe Leu Asn Asn Gly Glu His Phe Val Pro Ser Ala Gly Thr Asp Ser 
        675                 680                 685             


Lys Thr Cys Asn Leu Asp Met Gln Asp Asn Ala Ala Ala Asn 
    690                 695                 700         


<210>  4583
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  4583

Met Asn Pro Ala Leu Gly Asn Gln Thr Asp Val Ala Gly Leu Phe Leu 
1               5                   10                  15      


Ala Asn Ser Ser Glu Ala Leu Glu Arg Ala Val Arg Cys Cys Thr Gln 
            20                  25                  30          


Ala Ser Val Val Thr Asp Asp Gly Phe Ala Glu Gly Gly Pro Asp Glu 
        35                  40                  45              


Arg Ser Leu Tyr Ile Met Arg Val Val Gln Ile Ala Val Met Cys Val 
    50                  55                  60                  


Leu Ser Leu Thr Val Val Phe Gly Ile Phe Phe Leu Gly Cys Asn Leu 
65                  70                  75                  80  


Leu Ile Lys Ser Glu Gly Met Ile Asn Phe Leu Val Lys Asp Arg Arg 
                85                  90                  95      


Pro Ser Lys Glu Val Glu Ala Val Val Val Gly Pro Tyr 
            100                 105                 


<210>  4584
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  4584

Met Val Leu Met Gln Asp Lys Gly Ser Ser Gln Gln Trp Pro Gly Leu 
1               5                   10                  15      


Gly Gly Glu Gly Gly Gly Thr Gly Pro Leu Ser Met Leu Arg Ala Ala 
            20                  25                  30          


Leu Leu Leu Ile Ser Leu Pro Trp Gly Ala Gln Gly Thr Ala Ser Thr 
        35                  40                  45              


Ser Leu Ser Thr Ala Gly Gly His Thr Val Pro Pro Thr Gly Gly Arg 
    50                  55                  60                  


Tyr Leu Ser Ile Gly Asp Gly Ser Val Met Glu Phe Glu Phe Pro Glu 
65                  70                  75                  80  


Asp Ser Glu Gly Ile Ile Val Ile Ser Ser Gln Tyr Pro Gly Gln Ala 
                85                  90                  95      


Asn Arg Thr Ala Pro Gly Pro Met Leu Arg Val Thr Ser Leu Asp Thr 
            100                 105                 110         


Glu Val Leu Thr Ile Lys Asn Val Ser Ala Ile Thr Trp Gly Gly Gly 
        115                 120                 125             


Gly Gly Phe Val Val Ser Ile His Ser Gly Leu Ala Gly Leu Ala Pro 
    130                 135                 140                 


Leu His Ile Gln Leu Val Asp Ala His Glu Ala Pro Pro Thr Leu Ile 
145                 150                 155                 160 


Glu Glu Arg Arg Asp Phe Cys Ile Lys Val Ser Pro Ala Glu Asp Thr 
                165                 170                 175     


Pro Ala Thr Leu Ser Ala Asp Leu Ala His Phe Ser Glu Asn Pro Ile 
            180                 185                 190         


Leu Tyr Leu Leu Leu Pro Leu Ile Phe Val Asn Lys Cys Ser Phe Gly 
        195                 200                 205             


Cys Lys Val Glu Leu Glu Val Leu Lys Gly Leu Met Gln Ser Pro Gln 
    210                 215                 220                 


Pro Met Leu Leu Gly Leu Leu Gly Gln Phe Leu Val Met Pro Leu Tyr 
225                 230                 235                 240 


Ala Phe Leu Met Ala Lys Val Phe Met Leu Pro Lys Ala Leu Ala Leu 
                245                 250                 255     


Gly Leu Ile Ile Thr Cys Ser Ser Pro Gly Gly Gly Gly Ser Tyr Leu 
            260                 265                 270         


Phe Ser Leu Leu Leu Gly Gly Asp Val Thr Leu Ala Ile Ser Met Thr 
        275                 280                 285             


Phe Leu Ser Thr Val Ala Ala Thr Gly Phe Leu Pro Leu Ser Ser Ala 
    290                 295                 300                 


Ile Tyr Ser Arg Leu Leu Ser Ile His Glu Thr Leu His Val Pro Ile 
305                 310                 315                 320 


Ser Lys Ile Leu Gly Thr Leu Leu Phe Ile Ala Ile Pro Ile Ala Val 
                325                 330                 335     


Gly Val Leu Ile Lys Ser Lys Leu Pro Lys Phe Ser Gln Leu Leu Leu 
            340                 345                 350         


Gln Val Val Lys Pro Phe Ser Phe Val Leu Leu Leu Gly Gly Leu Phe 
        355                 360                 365             


Leu Ala Tyr Arg Met Gly Val Phe Ile Leu Ala Gly Ile Arg Leu Pro 
    370                 375                 380                 


Ile Val Leu Val Gly Ile Thr Val Pro Leu Val Gly Leu Leu Val Gly 
385                 390                 395                 400 


Tyr Cys Leu Ala Thr Cys Leu Lys Leu Pro Val Ala Gln Arg Arg Thr 
                405                 410                 415     


Val Ser Ile Glu Val Gly Val Gln Asn Ser Leu Leu Ala Leu Ala Met 
            420                 425                 430         


Leu Gln Leu Ser Leu Arg Arg Leu Gln Ala Asp Tyr Ala Ser Gln Ala 
        435                 440                 445             


Pro Phe Ile Val Ala Leu Ser Gly Thr Ser Glu Met Leu Ala Leu Val 
    450                 455                 460                 


Ile Gly His Phe Ile Tyr Ser Ser Leu Phe Pro Val Pro 
465                 470                 475         


<210>  4585
<211>  523
<212>  PRT
<213>  Homo sapiens

<400>  4585

Met Ala Gly His Thr Gln Gln Pro Ser Gly Arg Gly Asn Pro Arg Pro 
1               5                   10                  15      


Ala Pro Ser Pro Ser Pro Val Pro Gly Thr Val Pro Gly Ala Ser Glu 
            20                  25                  30          


Arg Val Ala Leu Lys Lys Glu Ile Gly Leu Leu Ser Ala Cys Thr Ile 
        35                  40                  45              


Ile Ile Gly Asn Ile Ile Gly Ser Gly Ile Phe Ile Ser Pro Lys Gly 
    50                  55                  60                  


Val Leu Glu His Ser Gly Ser Val Gly Leu Ala Leu Phe Val Trp Val 
65                  70                  75                  80  


Leu Gly Gly Gly Val Thr Ala Leu Gly Ser Leu Cys Tyr Ala Glu Leu 
                85                  90                  95      


Gly Val Ala Ile Pro Lys Ser Gly Gly Asp Tyr Ala Tyr Val Thr Glu 
            100                 105                 110         


Ile Phe Gly Gly Leu Ala Gly Phe Leu Leu Leu Trp Ser Ala Val Leu 
        115                 120                 125             


Ile Met Tyr Pro Thr Ser Leu Ala Val Ile Ser Met Thr Phe Ser Asn 
    130                 135                 140                 


Tyr Val Leu Gln Pro Val Phe Pro Asn Cys Ile Pro Pro Thr Thr Ala 
145                 150                 155                 160 


Ser Arg Val Leu Ser Met Ala Cys Leu Met Leu Leu Thr Trp Val Asn 
                165                 170                 175     


Ser Ser Ser Val Arg Trp Ala Thr Arg Ile Gln Asp Met Phe Thr Gly 
            180                 185                 190         


Gly Lys Leu Leu Ala Leu Ser Leu Ile Ile Gly Val Gly Leu Leu Gln 
        195                 200                 205             


Ile Phe Gln Gly His Phe Glu Glu Leu Arg Pro Ser Asn Ala Phe Ala 
    210                 215                 220                 


Phe Trp Met Thr Pro Ser Val Gly His Leu Ala Leu Ala Phe Leu Gln 
225                 230                 235                 240 


Gly Ser Phe Ala Phe Ser Gly Trp Asn Phe Leu Asn Tyr Val Thr Glu 
                245                 250                 255     


Glu Met Val Asp Ala Arg Lys Asn Leu Pro Arg Ala Ile Phe Ile Ser 
            260                 265                 270         


Ile Pro Leu Val Thr Phe Val Tyr Thr Phe Thr Asn Ile Ala Tyr Phe 
        275                 280                 285             


Thr Ala Met Ser Pro Gln Glu Leu Leu Ser Ser Asn Ala Val Ala Val 
    290                 295                 300                 


Thr Phe Gly Glu Lys Leu Leu Gly Tyr Phe Ser Trp Val Met Pro Val 
305                 310                 315                 320 


Ser Val Ala Leu Ser Thr Phe Gly Gly Ile Asn Gly Tyr Leu Phe Thr 
                325                 330                 335     


Tyr Ser Arg Leu Cys Phe Ser Gly Ala Arg Glu Gly His Leu Pro Ser 
            340                 345                 350         


Leu Leu Ala Met Ile His Val Arg His Cys Thr Pro Ile Pro Ala Leu 
        355                 360                 365             


Leu Val Cys Cys Gly Ala Thr Ala Val Ile Met Leu Val Gly Asp Thr 
    370                 375                 380                 


Tyr Thr Leu Ile Asn Tyr Val Ser Phe Ile Asn Tyr Leu Cys Tyr Gly 
385                 390                 395                 400 


Val Thr Ile Leu Gly Leu Leu Leu Leu Arg Trp Arg Arg Pro Ala Leu 
                405                 410                 415     


His Arg Pro Ile Lys Val Asn Leu Leu Ile Pro Val Ala Tyr Leu Val 
            420                 425                 430         


Phe Trp Ala Phe Leu Leu Val Phe Ser Phe Ile Ser Glu Pro Met Val 
        435                 440                 445             


Cys Gly Val Gly Val Ile Ile Ile Leu Thr Gly Val Pro Ile Phe Phe 
    450                 455                 460                 


Leu Gly Val Phe Trp Arg Ser Lys Pro Lys Cys Val His Arg Leu Thr 
465                 470                 475                 480 


Glu Ser Met Thr His Trp Gly Gln Glu Leu Cys Phe Val Val Tyr Pro 
                485                 490                 495     


Gln Asp Ala Pro Glu Glu Glu Glu Asn Gly Pro Cys Pro Pro Ser Leu 
            500                 505                 510         


Leu Pro Ala Thr Asp Lys Pro Ser Lys Pro Gln 
        515                 520             


<210>  4586
<211>  588
<212>  PRT
<213>  Homo sapiens

<400>  4586

Met Ala Arg Gly Gly Ala Gly Ala Glu Glu Ala Ser Leu Arg Ser Asn 
1               5                   10                  15      


Ala Leu Ser Trp Leu Ala Cys Gly Leu Leu Ala Leu Leu Ala Asn Ala 
            20                  25                  30          


Trp Ile Ile Leu Ser Ile Ser Ala Lys Gln Gln Lys His Lys Pro Leu 
        35                  40                  45              


Glu Leu Leu Leu Cys Phe Leu Ala Gly Thr His Ile Leu Met Ala Ala 
    50                  55                  60                  


Val Pro Leu Thr Thr Phe Ala Val Val Gln Leu Arg Arg Gln Ala Ser 
65                  70                  75                  80  


Ser Asp Tyr Asp Trp Asn Glu Ser Ile Cys Lys Val Phe Val Ser Thr 
                85                  90                  95      


Tyr Tyr Thr Leu Ala Leu Ala Thr Cys Phe Thr Val Ala Ser Leu Ser 
            100                 105                 110         


Tyr His Arg Met Trp Met Val Arg Trp Pro Val Asn Tyr Arg Leu Ser 
        115                 120                 125             


Asn Ala Lys Lys Gln Ala Leu His Ala Val Met Gly Ile Trp Met Val 
    130                 135                 140                 


Ser Phe Ile Leu Ser Thr Leu Pro Ser Ile Gly Trp His Asn Asn Gly 
145                 150                 155                 160 


Glu Arg Tyr Tyr Ala Arg Gly Cys Gln Phe Ile Val Ser Lys Ile Gly 
                165                 170                 175     


Leu Gly Phe Gly Val Cys Phe Ser Leu Leu Leu Leu Gly Gly Ile Val 
            180                 185                 190         


Met Gly Leu Val Cys Val Ala Ile Thr Phe Tyr Gln Thr Leu Trp Ala 
        195                 200                 205             


Arg Pro Arg Arg Ala Arg Gln Ala Arg Arg Val Gly Gly Gly Gly Gly 
    210                 215                 220                 


Thr Lys Ala Gly Gly Pro Gly Ala Leu Gly Thr Arg Pro Ala Phe Glu 
225                 230                 235                 240 


Val Pro Ala Ile Val Val Glu Asp Ala Arg Gly Lys Arg Arg Ser Ser 
                245                 250                 255     


Leu Asp Gly Ser Glu Ser Ala Lys Thr Ser Leu Gln Val Thr Asn Leu 
            260                 265                 270         


Val Ser Ala Ile Val Phe Leu Tyr Asp Ser Leu Thr Gly Val Pro Ile 
        275                 280                 285             


Leu Val Val Ser Phe Phe Ser Leu Lys Ser Asp Ser Ala Pro Pro Trp 
    290                 295                 300                 


Met Val Leu Ala Val Leu Trp Cys Ser Met Ala Gln Thr Leu Leu Leu 
305                 310                 315                 320 


Pro Ser Phe Ile Trp Ser Cys Glu Arg Tyr Arg Ala Asp Val Arg Thr 
                325                 330                 335     


Val Trp Glu Gln Cys Val Ala Ile Met Ser Glu Glu Asp Gly Asp Asp 
            340                 345                 350         


Asp Gly Gly Cys Asp Asp Tyr Ala Glu Gly Arg Val Cys Lys Val Arg 
        355                 360                 365             


Phe Asp Ala Asn Gly Ala Thr Gly Pro Gly Ser Arg Asp Pro Ala Gln 
    370                 375                 380                 


Val Lys Leu Leu Pro Gly Arg His Met Leu Phe Pro Pro Leu Glu Arg 
385                 390                 395                 400 


Val His Tyr Leu Gln Val Pro Leu Ser Arg Arg Leu Ser His Asp Glu 
                405                 410                 415     


Thr Asn Ile Phe Ser Thr Pro Arg Glu Pro Gly Ser Phe Leu His Lys 
            420                 425                 430         


Trp Ser Ser Ser Asp Asp Ile Arg Val Leu Pro Ala Gln Ser Arg Ala 
        435                 440                 445             


Leu Gly Gly Pro Pro Glu Tyr Leu Gly Gln Arg His Arg Leu Glu Asp 
    450                 455                 460                 


Glu Glu Asp Glu Glu Glu Ala Glu Gly Gly Gly Leu Ala Ser Leu Arg 
465                 470                 475                 480 


Gln Phe Leu Glu Ser Gly Val Leu Gly Ser Gly Gly Gly Pro Pro Arg 
                485                 490                 495     


Gly Pro Gly Phe Phe Arg Glu Glu Ile Thr Thr Phe Ile Asp Glu Thr 
            500                 505                 510         


Pro Leu Pro Ser Pro Thr Ala Ser Pro Gly His Ser Pro Arg Arg Pro 
        515                 520                 525             


Arg Pro Leu Gly Leu Ser Pro Arg Arg Leu Ser Leu Gly Ser Pro Glu 
    530                 535                 540                 


Ser Arg Ala Val Gly Leu Pro Leu Gly Leu Ser Ala Gly Arg Arg Cys 
545                 550                 555                 560 


Ser Leu Thr Gly Gly Glu Glu Ser Ala Arg Ala Trp Gly Gly Ser Trp 
                565                 570                 575     


Gly Pro Gly Asn Pro Ile Phe Pro Gln Leu Thr Leu 
            580                 585             


<210>  4587
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  4587

Met Met Asp Val Asn Ser Ser Gly Arg Pro Asp Leu Tyr Gly His Leu 
1               5                   10                  15      


Arg Ser Phe Leu Leu Pro Glu Val Gly Arg Gly Leu Pro Asp Leu Ser 
            20                  25                  30          


Pro Asp Gly Gly Ala Asp Pro Val Ala Gly Ser Trp Ala Pro His Leu 
        35                  40                  45              


Leu Ser Glu Val Thr Ala Ser Pro Ala Pro Thr Trp Asp Ala Pro Pro 
    50                  55                  60                  


Asp Asn Ala Ser Gly Cys Gly Glu Gln Ile Asn Tyr Gly Arg Val Glu 
65                  70                  75                  80  


Lys Val Val Ile Gly Ser Ile Leu Thr Leu Ile Thr Leu Leu Thr Ile 
                85                  90                  95      


Ala Gly Asn Cys Leu Val Val Ile Ser Val Cys Phe Val Lys Lys Leu 
            100                 105                 110         


Arg Gln Pro Ser Asn Tyr Leu Ile Val Ser Leu Ala Leu Ala Asp Leu 
        115                 120                 125             


Ser Val Ala Val Ala Val Met Pro Phe Val Ser Val Thr Asp Leu Ile 
    130                 135                 140                 


Gly Gly Lys Trp Ile Phe Gly His Phe Phe Cys Asn Val Phe Ile Ala 
145                 150                 155                 160 


Met Asp Val Met Cys Cys Thr Ala Ser Ile Met Thr Leu Cys Val Ile 
                165                 170                 175     


Ser Ile Asp Arg Tyr Leu Gly Ile Thr Arg Pro Leu Thr Tyr Pro Val 
            180                 185                 190         


Arg Gln Asn Gly Lys Cys Met Ala Lys Met Ile Leu Ser Val Trp Leu 
        195                 200                 205             


Leu Ser Ala Ser Ile Thr Leu Pro Pro Leu Phe Gly Trp Ala Gln Asn 
    210                 215                 220                 


Val Asn Asp Asp Lys Val Cys Leu Ile Ser Gln Asp Phe Gly Tyr Thr 
225                 230                 235                 240 


Ile Tyr Ser Thr Ala Val Ala Phe Tyr Ile Pro Met Ser Val Met Leu 
                245                 250                 255     


Phe Met Tyr Tyr Gln Ile Tyr Lys Ala Ala Arg Lys Ser Ala Ala Lys 
            260                 265                 270         


His Lys Phe Pro Gly Phe Pro Arg Val Glu Pro Asp Ser Val Ile Ala 
        275                 280                 285             


Leu Asn Gly Ile Val Lys Leu Gln Lys Glu Val Glu Glu Cys Ala Asn 
    290                 295                 300                 


Leu Ser Arg Leu Leu Lys His Glu Arg Lys Asn Ile Ser Ile Phe Lys 
305                 310                 315                 320 


Arg Glu Gln Lys Ala Ala Thr Thr Leu Gly Ile Ile Val Gly Ala Phe 
                325                 330                 335     


Thr Val Cys Trp Leu Pro Phe Phe Leu Leu Ser Thr Ala Arg Pro Phe 
            340                 345                 350         


Ile Cys Gly Thr Ser Cys Ser Cys Ile Pro Leu Trp Val Glu Arg Thr 
        355                 360                 365             


Phe Leu Trp Leu Gly Tyr Ala Asn Ser Leu Ile Asn Pro Phe Ile Tyr 
    370                 375                 380                 


Ala Phe Phe Asn Arg Asp Leu Arg Thr Thr Tyr Arg Ser Leu Leu Gln 
385                 390                 395                 400 


Cys Gln Tyr Arg Asn Ile Asn Arg Lys Leu Ser Ala Ala Gly Met His 
                405                 410                 415     


Glu Ala Leu Lys Leu Ala Glu Arg Pro Glu Arg Pro Glu Phe Val Leu 
            420                 425                 430         


Arg Ala Cys Thr Arg Arg Val Leu Leu Arg Pro Glu Lys Arg Pro Pro 
        435                 440                 445             


Val Ser Val Trp Val Leu Gln Ser Pro Asp His His Asn Trp Leu Ala 
    450                 455                 460                 


Asp Lys Met Leu Thr Thr Val Glu Lys Lys Val Met Ile His Asp 
465                 470                 475                 


<210>  4588
<211>  1531
<212>  PRT
<213>  Homo sapiens

<400>  4588

Met Ala Leu Arg Gly Phe Cys Ser Ala Asp Gly Ser Asp Pro Leu Trp 
1               5                   10                  15      


Asp Trp Asn Val Thr Trp Asn Thr Ser Asn Pro Asp Phe Thr Lys Cys 
            20                  25                  30          


Phe Gln Asn Thr Val Leu Val Trp Val Pro Cys Phe Tyr Leu Trp Ala 
        35                  40                  45              


Cys Phe Pro Phe Tyr Phe Leu Tyr Leu Ser Arg His Asp Arg Gly Tyr 
    50                  55                  60                  


Ile Gln Met Thr Pro Leu Asn Lys Thr Lys Thr Ala Leu Gly Phe Leu 
65                  70                  75                  80  


Leu Trp Ile Val Cys Trp Ala Asp Leu Phe Tyr Ser Phe Trp Glu Arg 
                85                  90                  95      


Ser Arg Gly Ile Phe Leu Ala Pro Val Phe Leu Val Ser Pro Thr Leu 
            100                 105                 110         


Leu Gly Ile Thr Met Leu Leu Ala Thr Phe Leu Ile Gln Leu Glu Arg 
        115                 120                 125             


Arg Lys Gly Val Gln Ser Ser Gly Ile Met Leu Thr Phe Trp Leu Val 
    130                 135                 140                 


Ala Leu Val Cys Ala Leu Ala Ile Leu Arg Ser Lys Ile Met Thr Ala 
145                 150                 155                 160 


Leu Lys Glu Asp Ala Gln Val Asp Leu Phe Arg Asp Ile Thr Phe Tyr 
                165                 170                 175     


Val Tyr Phe Ser Leu Leu Leu Ile Gln Leu Val Leu Ser Cys Phe Ser 
            180                 185                 190         


Asp Arg Ser Pro Leu Phe Ser Glu Thr Ile His Asp Pro Asn Pro Cys 
        195                 200                 205             


Pro Glu Ser Ser Ala Ser Phe Leu Ser Arg Ile Thr Phe Trp Trp Ile 
    210                 215                 220                 


Thr Gly Leu Ile Val Arg Gly Tyr Arg Gln Pro Leu Glu Gly Ser Asp 
225                 230                 235                 240 


Leu Trp Ser Leu Asn Lys Glu Asp Thr Ser Glu Gln Val Val Pro Val 
                245                 250                 255     


Leu Val Lys Asn Trp Lys Lys Glu Cys Ala Lys Thr Arg Lys Gln Pro 
            260                 265                 270         


Val Lys Val Val Tyr Ser Ser Lys Asp Pro Ala Gln Pro Lys Glu Ser 
        275                 280                 285             


Ser Lys Val Asp Ala Asn Glu Glu Val Glu Ala Leu Ile Val Lys Ser 
    290                 295                 300                 


Pro Gln Lys Glu Trp Asn Pro Ser Leu Phe Lys Val Leu Tyr Lys Thr 
305                 310                 315                 320 


Phe Gly Pro Tyr Phe Leu Met Ser Phe Phe Phe Lys Ala Ile His Asp 
                325                 330                 335     


Leu Met Met Phe Ser Gly Pro Gln Ile Leu Lys Leu Leu Ile Lys Phe 
            340                 345                 350         


Val Asn Asp Thr Lys Ala Pro Asp Trp Gln Gly Tyr Phe Tyr Thr Val 
        355                 360                 365             


Leu Leu Phe Val Thr Ala Cys Leu Gln Thr Leu Val Leu His Gln Tyr 
    370                 375                 380                 


Phe His Ile Cys Phe Val Ser Gly Met Arg Ile Lys Thr Ala Val Ile 
385                 390                 395                 400 


Gly Ala Val Tyr Arg Lys Ala Leu Val Ile Thr Asn Ser Ala Arg Lys 
                405                 410                 415     


Ser Ser Thr Val Gly Glu Ile Val Asn Leu Met Ser Val Asp Ala Gln 
            420                 425                 430         


Arg Phe Met Asp Leu Ala Thr Tyr Ile Asn Met Ile Trp Ser Ala Pro 
        435                 440                 445             


Leu Gln Val Ile Leu Ala Leu Tyr Leu Leu Trp Leu Asn Leu Gly Pro 
    450                 455                 460                 


Ser Val Leu Ala Gly Val Ala Val Met Val Leu Met Val Pro Val Asn 
465                 470                 475                 480 


Ala Val Met Ala Met Lys Thr Lys Thr Tyr Gln Val Ala His Met Lys 
                485                 490                 495     


Ser Lys Asp Asn Arg Ile Lys Leu Met Asn Glu Ile Leu Asn Gly Ile 
            500                 505                 510         


Lys Val Leu Lys Leu Tyr Ala Trp Glu Leu Ala Phe Lys Asp Lys Val 
        515                 520                 525             


Leu Ala Ile Arg Gln Glu Glu Leu Lys Val Leu Lys Lys Ser Ala Tyr 
    530                 535                 540                 


Leu Ser Ala Val Gly Thr Phe Thr Trp Val Cys Thr Pro Phe Leu Val 
545                 550                 555                 560 


Ala Leu Cys Thr Phe Ala Val Tyr Val Thr Ile Asp Glu Asn Asn Ile 
                565                 570                 575     


Leu Asp Ala Gln Thr Ala Phe Val Ser Leu Ala Leu Phe Asn Ile Leu 
            580                 585                 590         


Arg Phe Pro Leu Asn Ile Leu Pro Met Val Ile Ser Ser Ile Val Gln 
        595                 600                 605             


Ala Ser Val Ser Leu Lys Arg Leu Arg Ile Phe Leu Ser His Glu Glu 
    610                 615                 620                 


Leu Glu Pro Asp Ser Ile Glu Arg Arg Pro Val Lys Asp Gly Gly Gly 
625                 630                 635                 640 


Thr Asn Ser Ile Thr Val Arg Asn Ala Thr Phe Thr Trp Ala Arg Ser 
                645                 650                 655     


Asp Pro Pro Thr Leu Asn Gly Ile Thr Phe Ser Ile Pro Glu Gly Ala 
            660                 665                 670         


Leu Val Ala Val Val Gly Gln Val Gly Cys Gly Lys Ser Ser Leu Leu 
        675                 680                 685             


Ser Ala Leu Leu Ala Glu Met Asp Lys Val Glu Gly His Val Ala Ile 
    690                 695                 700                 


Lys Gly Ser Val Ala Tyr Val Pro Gln Gln Ala Trp Ile Gln Asn Asp 
705                 710                 715                 720 


Ser Leu Arg Glu Asn Ile Leu Phe Gly Cys Gln Leu Glu Glu Pro Tyr 
                725                 730                 735     


Tyr Arg Ser Val Ile Gln Ala Cys Ala Leu Leu Pro Asp Leu Glu Ile 
            740                 745                 750         


Leu Pro Ser Gly Asp Arg Thr Glu Ile Gly Glu Lys Gly Val Asn Leu 
        755                 760                 765             


Ser Gly Gly Gln Lys Gln Arg Val Ser Leu Ala Arg Ala Val Tyr Ser 
    770                 775                 780                 


Asn Ala Asp Ile Tyr Leu Phe Asp Asp Pro Leu Ser Ala Val Asp Ala 
785                 790                 795                 800 


His Val Gly Lys His Ile Phe Glu Asn Val Ile Gly Pro Lys Gly Met 
                805                 810                 815     


Leu Lys Asn Lys Thr Arg Ile Leu Val Thr His Ser Met Ser Tyr Leu 
            820                 825                 830         


Pro Gln Val Asp Val Ile Ile Val Met Ser Gly Gly Lys Ile Ser Glu 
        835                 840                 845             


Met Gly Ser Tyr Gln Glu Leu Leu Ala Arg Asp Gly Ala Phe Ala Glu 
    850                 855                 860                 


Phe Leu Arg Thr Tyr Ala Ser Thr Glu Gln Glu Gln Asp Ala Glu Glu 
865                 870                 875                 880 


Asn Gly Val Thr Gly Val Ser Gly Pro Gly Lys Glu Ala Lys Gln Met 
                885                 890                 895     


Glu Asn Gly Met Leu Val Thr Asp Ser Ala Gly Lys Gln Leu Gln Arg 
            900                 905                 910         


Gln Leu Ser Ser Ser Ser Ser Tyr Ser Gly Asp Ile Ser Arg His His 
        915                 920                 925             


Asn Ser Thr Ala Glu Leu Gln Lys Ala Glu Ala Lys Lys Glu Glu Thr 
    930                 935                 940                 


Trp Lys Leu Met Glu Ala Asp Lys Ala Gln Thr Gly Gln Val Lys Leu 
945                 950                 955                 960 


Ser Val Tyr Trp Asp Tyr Met Lys Ala Ile Gly Leu Phe Ile Ser Phe 
                965                 970                 975     


Leu Ser Ile Phe Leu Phe Met Cys Asn His Val Ser Ala Leu Ala Ser 
            980                 985                 990         


Asn Tyr Trp Leu Ser Leu Trp Thr  Asp Asp Pro Ile Val  Asn Gly Thr 
        995                 1000                 1005             


Gln Glu  His Thr Lys Val Arg  Leu Ser Val Tyr Gly  Ala Leu Gly 
    1010                 1015                 1020             


Ile Ser  Gln Gly Ile Ala Val  Phe Gly Tyr Ser Met  Ala Val Ser 
    1025                 1030                 1035             


Ile Gly  Gly Ile Leu Ala Ser  Arg Cys Leu His Val  Asp Leu Leu 
    1040                 1045                 1050             


His Ser  Ile Leu Arg Ser Pro  Met Ser Phe Phe Glu  Arg Thr Pro 
    1055                 1060                 1065             


Ser Gly  Asn Leu Val Asn Arg  Phe Ser Lys Glu Leu  Asp Thr Val 
    1070                 1075                 1080             


Asp Ser  Met Ile Pro Glu Val  Ile Lys Met Phe Met  Gly Ser Leu 
    1085                 1090                 1095             


Phe Asn  Val Ile Gly Ala Cys  Ile Val Ile Leu Leu  Ala Thr Pro 
    1100                 1105                 1110             


Ile Ala  Ala Ile Ile Ile Pro  Pro Leu Gly Leu Ile  Tyr Phe Phe 
    1115                 1120                 1125             


Val Gln  Arg Phe Tyr Val Ala  Ser Ser Arg Gln Leu  Lys Arg Leu 
    1130                 1135                 1140             


Glu Ser  Val Ser Arg Ser Pro  Val Tyr Ser His Phe  Asn Glu Thr 
    1145                 1150                 1155             


Leu Leu  Gly Val Ser Val Ile  Arg Ala Phe Glu Glu  Gln Glu Arg 
    1160                 1165                 1170             


Phe Ile  His Gln Ser Asp Leu  Lys Val Asp Glu Asn  Gln Lys Ala 
    1175                 1180                 1185             


Tyr Tyr  Pro Ser Ile Val Ala  Asn Arg Trp Leu Ala  Val Arg Leu 
    1190                 1195                 1200             


Glu Cys  Val Gly Asn Cys Ile  Val Leu Phe Ala Ala  Leu Phe Ala 
    1205                 1210                 1215             


Val Ile  Ser Arg His Ser Leu  Ser Ala Gly Leu Val  Gly Leu Ser 
    1220                 1225                 1230             


Val Ser  Tyr Ser Leu Gln Val  Thr Thr Tyr Leu Asn  Trp Leu Val 
    1235                 1240                 1245             


Arg Met  Ser Ser Glu Met Glu  Thr Asn Ile Val Ala  Val Glu Arg 
    1250                 1255                 1260             


Leu Lys  Glu Tyr Ser Glu Thr  Glu Lys Glu Ala Pro  Trp Gln Ile 
    1265                 1270                 1275             


Gln Glu  Thr Ala Pro Pro Ser  Ser Trp Pro Gln Val  Gly Arg Val 
    1280                 1285                 1290             


Glu Phe  Arg Asn Tyr Cys Leu  Arg Tyr Arg Glu Asp  Leu Asp Phe 
    1295                 1300                 1305             


Val Leu  Arg His Ile Asn Val  Thr Ile Asn Gly Gly  Glu Lys Val 
    1310                 1315                 1320             


Gly Ile  Val Gly Arg Thr Gly  Ala Gly Lys Ser Ser  Leu Thr Leu 
    1325                 1330                 1335             


Gly Leu  Phe Arg Ile Asn Glu  Ser Ala Glu Gly Glu  Ile Ile Ile 
    1340                 1345                 1350             


Asp Gly  Ile Asn Ile Ala Lys  Ile Gly Leu His Asp  Leu Arg Phe 
    1355                 1360                 1365             


Lys Ile  Thr Ile Ile Pro Gln  Asp Pro Val Leu Phe  Ser Gly Ser 
    1370                 1375                 1380             


Leu Arg  Met Asn Leu Asp Pro  Phe Ser Gln Tyr Ser  Asp Glu Glu 
    1385                 1390                 1395             


Val Trp  Thr Ser Leu Glu Leu  Ala His Leu Lys Asp  Phe Val Ser 
    1400                 1405                 1410             


Ala Leu  Pro Asp Lys Leu Asp  His Glu Cys Ala Glu  Gly Gly Glu 
    1415                 1420                 1425             


Asn Leu  Ser Val Gly Gln Arg  Gln Leu Val Cys Leu  Ala Arg Ala 
    1430                 1435                 1440             


Leu Leu  Arg Lys Thr Lys Ile  Leu Val Leu Asp Glu  Ala Thr Ala 
    1445                 1450                 1455             


Ala Val  Asp Leu Glu Thr Asp  Asp Leu Ile Gln Ser  Thr Ile Arg 
    1460                 1465                 1470             


Thr Gln  Phe Glu Asp Cys Thr  Val Leu Thr Ile Ala  His Arg Leu 
    1475                 1480                 1485             


Asn Thr  Ile Met Asp Tyr Thr  Arg Val Ile Val Leu  Asp Lys Gly 
    1490                 1495                 1500             


Glu Ile  Gln Glu Tyr Gly Ala  Pro Ser Asp Leu Leu  Gln Gln Arg 
    1505                 1510                 1515             


Gly Leu  Phe Tyr Ser Met Ala  Lys Asp Ala Gly Leu  Val 
    1520                 1525                 1530     


<210>  4589
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  4589

Met Met Asp Val Asn Ser Ser Gly Arg Pro Asp Leu Tyr Gly His Leu 
1               5                   10                  15      


Arg Ser Phe Leu Leu Pro Glu Val Gly Arg Gly Leu Pro Asp Leu Ser 
            20                  25                  30          


Pro Asp Gly Gly Ala Asp Pro Val Ala Gly Ser Trp Ala Pro His Leu 
        35                  40                  45              


Leu Ser Glu Val Thr Ala Ser Pro Ala Pro Thr Trp Asp Ala Pro Pro 
    50                  55                  60                  


Asp Asn Ala Ser Gly Cys Gly Glu Gln Ile Asn Tyr Gly Arg Val Glu 
65                  70                  75                  80  


Lys Val Val Ile Gly Ser Ile Leu Thr Leu Ile Thr Leu Leu Thr Ile 
                85                  90                  95      


Ala Gly Asn Cys Leu Val Val Ile Ser Val Cys Phe Val Lys Lys Leu 
            100                 105                 110         


Arg Gln Pro Ser Asn Tyr Leu Ile Val Ser Leu Ala Leu Ala Asp Leu 
        115                 120                 125             


Ser Val Ala Val Ala Val Met Pro Phe Val Ser Val Thr Asp Leu Ile 
    130                 135                 140                 


Gly Gly Lys Trp Ile Phe Gly His Phe Phe Cys Asn Val Phe Ile Ala 
145                 150                 155                 160 


Met Asp Val Met Cys Cys Thr Ala Ser Ile Met Thr Leu Cys Val Ile 
                165                 170                 175     


Ser Ile Asp Arg Tyr Leu Gly Ile Thr Arg Pro Leu Thr Tyr Pro Val 
            180                 185                 190         


Arg Gln Asn Gly Lys Cys Met Ala Lys Met Ile Leu Ser Val Trp Leu 
        195                 200                 205             


Leu Ser Ala Ser Ile Thr Leu Pro Pro Leu Phe Gly Trp Ala Gln Asn 
    210                 215                 220                 


Val Asn Asp Asp Lys Val Cys Leu Ile Ser Gln Asp Phe Gly Tyr Thr 
225                 230                 235                 240 


Ile Tyr Ser Thr Ala Val Ala Phe Tyr Ile Pro Met Ser Val Met Leu 
                245                 250                 255     


Phe Met Tyr Tyr Gln Ile Tyr Lys Ala Ala Arg Lys Ser Ala Ala Lys 
            260                 265                 270         


His Lys Phe Pro Gly Phe Pro Arg Val Glu Pro Asp Ser Val Ile Ala 
        275                 280                 285             


Leu Asn Gly Ile Val Lys Leu Gln Lys Glu Val Glu Glu Cys Ala Asn 
    290                 295                 300                 


Leu Ser Arg Leu Leu Lys His Glu Arg Lys Asn Ile Ser Ile Phe Lys 
305                 310                 315                 320 


Arg Glu Gln Lys Ala Ala Thr Thr Leu Gly Ile Ile Val Gly Ala Phe 
                325                 330                 335     


Thr Val Cys Trp Leu Pro Phe Phe Leu Leu Ser Thr Ala Arg Pro Phe 
            340                 345                 350         


Ile Cys Gly Thr Ser Cys Ser Cys Ile Pro Leu Trp Val Glu Arg Thr 
        355                 360                 365             


Phe Leu Trp Leu Gly Tyr Ala Asn Ser Leu Ile Asn Pro Phe Ile Tyr 
    370                 375                 380                 


Ala Phe Phe Asn Arg Asp Leu Arg Thr Thr Tyr Arg Ser Leu Leu Gln 
385                 390                 395                 400 


Cys Gln Tyr Arg Asn Ile Asn Arg Lys Leu Ser Ala Ala Gly Met His 
                405                 410                 415     


Glu Ala Leu Lys Leu Ala Glu Arg Pro Glu Arg Pro Glu Phe Val Leu 
            420                 425                 430         


<210>  4590
<211>  512
<212>  PRT
<213>  Homo sapiens

<400>  4590

Met Leu Phe Glu Gly Leu Asp Leu Val Ser Ala Leu Ala Thr Leu Ala 
1               5                   10                  15      


Ala Cys Leu Val Ser Val Thr Leu Leu Leu Ala Val Ser Gln Gln Leu 
            20                  25                  30          


Trp Gln Leu Arg Trp Ala Ala Thr Arg Asp Lys Ser Cys Lys Leu Pro 
        35                  40                  45              


Ile Pro Lys Gly Ser Met Gly Phe Pro Leu Ile Gly Glu Thr Gly His 
    50                  55                  60                  


Trp Leu Leu Gln Gly Ser Gly Phe Gln Ser Ser Arg Arg Glu Lys Tyr 
65                  70                  75                  80  


Gly Asn Val Phe Lys Thr His Leu Leu Gly Arg Pro Leu Ile Arg Val 
                85                  90                  95      


Thr Gly Ala Glu Asn Val Arg Lys Ile Leu Met Gly Glu His His Leu 
            100                 105                 110         


Val Ser Thr Glu Trp Pro Arg Ser Thr Arg Met Leu Leu Gly Pro Asn 
        115                 120                 125             


Thr Val Ser Asn Ser Ile Gly Asp Ile His Arg Asn Lys Arg Lys Val 
    130                 135                 140                 


Phe Ser Lys Ile Phe Ser His Glu Ala Leu Glu Ser Tyr Leu Pro Lys 
145                 150                 155                 160 


Ile Gln Leu Val Ile Gln Asp Thr Leu Arg Ala Trp Ser Ser His Pro 
                165                 170                 175     


Glu Ala Ile Asn Val Tyr Gln Glu Ala Gln Lys Leu Thr Phe Arg Met 
            180                 185                 190         


Ala Ile Arg Val Leu Leu Gly Phe Ser Ile Pro Glu Glu Asp Leu Gly 
        195                 200                 205             


His Leu Phe Glu Val Tyr Gln Gln Phe Val Asp Asn Val Phe Ser Leu 
    210                 215                 220                 


Pro Val Asp Leu Pro Phe Ser Gly Tyr Arg Arg Gly Ile Gln Ala Arg 
225                 230                 235                 240 


Gln Ile Leu Gln Lys Gly Leu Glu Lys Ala Ile Arg Glu Lys Leu Gln 
                245                 250                 255     


Cys Thr Gln Gly Lys Asp Tyr Leu Asp Ala Leu Asp Leu Leu Ile Glu 
            260                 265                 270         


Ser Ser Lys Glu His Gly Lys Glu Met Thr Met Gln Glu Leu Lys Asp 
        275                 280                 285             


Gly Thr Leu Glu Leu Ile Phe Ala Ala Tyr Ala Thr Thr Ala Ser Ala 
    290                 295                 300                 


Ser Thr Ser Leu Ile Met Gln Leu Leu Lys His Pro Thr Val Leu Glu 
305                 310                 315                 320 


Lys Leu Arg Asp Glu Leu Arg Ala His Gly Ile Leu His Ser Gly Gly 
                325                 330                 335     


Cys Pro Cys Glu Gly Thr Leu Arg Leu Asp Thr Leu Ser Gly Leu Arg 
            340                 345                 350         


Tyr Leu Asp Cys Val Ile Lys Glu Val Met Arg Leu Phe Thr Pro Ile 
        355                 360                 365             


Ser Gly Gly Tyr Arg Thr Val Leu Gln Thr Phe Glu Leu Asp Gly Phe 
    370                 375                 380                 


Gln Ile Pro Lys Gly Trp Ser Val Met Tyr Ser Ile Arg Asp Thr His 
385                 390                 395                 400 


Asp Thr Ala Pro Val Phe Lys Asp Val Asn Val Phe Asp Pro Asp Arg 
                405                 410                 415     


Phe Ser Gln Ala Arg Ser Glu Asp Lys Asp Gly Arg Phe His Tyr Leu 
            420                 425                 430         


Pro Phe Gly Gly Gly Val Arg Thr Cys Leu Gly Lys His Leu Ala Lys 
        435                 440                 445             


Leu Phe Leu Lys Val Leu Ala Val Glu Leu Ala Ser Thr Ser Arg Phe 
    450                 455                 460                 


Glu Leu Ala Thr Arg Thr Phe Pro Arg Ile Thr Leu Val Pro Val Leu 
465                 470                 475                 480 


His Pro Val Asp Gly Leu Ser Val Lys Phe Phe Gly Leu Asp Ser Asn 
                485                 490                 495     


Gln Asn Glu Ile Leu Pro Glu Thr Glu Ala Met Leu Ser Ala Thr Val 
            500                 505                 510         


<210>  4591
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  4591

Met Ala Ala Leu Lys Ser Trp Leu Ser Arg Ser Val Thr Ser Phe Phe 
1               5                   10                  15      


Arg Tyr Arg Gln Cys Leu Cys Val Pro Val Val Ala Asn Phe Lys Lys 
            20                  25                  30          


Arg Cys Phe Ser Glu Leu Ile Arg Pro Trp His Lys Thr Val Thr Ile 
        35                  40                  45              


Gly Phe Gly Val Thr Leu Cys Ala Val Pro Ile Ala Gln Lys Ser Glu 
    50                  55                  60                  


Pro His Ser Leu Ser Ser Glu Ala Leu Met Arg Arg Ala Val Ser Leu 
65                  70                  75                  80  


Val Thr Asp Ser Thr Ser Thr Phe Leu Ser Gln Thr Thr Tyr Ala Leu 
                85                  90                  95      


Ile Glu Ala Ile Thr Glu Tyr Thr Lys Ala Val Tyr Thr Leu Thr Ser 
            100                 105                 110         


Leu Tyr Arg Gln Tyr Thr Ser Leu Leu Gly Lys Met Asn Ser Glu Glu 
        115                 120                 125             


Glu Asp Glu Val Trp Gln Val Ile Ile Gly Ala Arg Ala Glu Met Thr 
    130                 135                 140                 


Ser Lys His Gln Glu Tyr Leu Lys Leu Glu Thr Thr Trp Met Thr Ala 
145                 150                 155                 160 


Val Gly Leu Ser Glu Met Ala Ala Glu Ala Ala Tyr Gln Thr Gly Ala 
                165                 170                 175     


Asp Gln Ala Ser Ile Thr Ala Arg Asn His Ile Gln Leu Val Lys Leu 
            180                 185                 190         


Gln Val Glu Glu Val His Gln Leu Ser Arg Lys Ala Glu Thr Lys Leu 
        195                 200                 205             


Ala Glu Ala Gln Ile Glu Glu Leu Arg Gln Lys Thr Gln Glu Glu Gly 
    210                 215                 220                 


Glu Glu Arg Ala Glu Ser Glu Gln Glu Ala Tyr Leu Arg Glu Asp 
225                 230                 235                 


<210>  4592
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  4592

Met Leu Gln Asp Pro Asp Ser Asp Gln Pro Leu Asn Ser Leu Asp Val 
1               5                   10                  15      


Lys Pro Leu Arg Lys Pro Arg Ile Pro Met Glu Thr Phe Arg Lys Val 
            20                  25                  30          


Gly Ile Pro Ile Ile Ile Ala Leu Leu Ser Leu Ala Ser Ile Ile Ile 
        35                  40                  45              


Val Val Val Leu Ile Lys Val Ile Leu Asp Lys Tyr Tyr Phe Leu Cys 
    50                  55                  60                  


Gly Gln Pro Leu His Phe Ile Pro Arg Lys Gln Leu Cys Asp Gly Glu 
65                  70                  75                  80  


Leu Asp Cys Pro Leu Gly Glu Asp Glu Glu His Cys Val Lys Ser Phe 
                85                  90                  95      


Pro Glu Gly Pro Ala Val Ala Val Arg Leu Ser Lys Asp Arg Ser Thr 
            100                 105                 110         


Leu Gln Val Leu Asp Ser Ala Thr Gly Asn Trp Phe Ser Ala Cys Phe 
        115                 120                 125             


Asp Asn Phe Thr Glu Ala Leu Ala Glu Thr Ala Cys Arg Gln Met Gly 
    130                 135                 140                 


Tyr Ser Ser Lys Pro Thr Phe Arg Ala Val Glu Ile Gly Pro Asp Gln 
145                 150                 155                 160 


Asp Leu Asp Val Val Glu Ile Thr Glu Asn Ser Gln Glu Leu Arg Met 
                165                 170                 175     


Arg Asn Ser Ser Gly Pro Cys Leu Ser Gly Ser Leu Val Ser Leu His 
            180                 185                 190         


Cys Leu Ala Cys Gly Lys Ser Leu Lys Thr Pro Arg Val Val Gly Gly 
        195                 200                 205             


Glu Glu Ala Ser Val Asp Ser Trp Pro Trp Gln Val Ser Ile Gln Tyr 
    210                 215                 220                 


Asp Lys Gln His Val Cys Gly Gly Ser Ile Leu Asp Pro His Trp Val 
225                 230                 235                 240 


Leu Thr Ala Ala His Cys Phe Arg Lys His Thr Asp Val Phe Asn Trp 
                245                 250                 255     


Lys Val Arg Ala Gly Ser Asp Lys Leu Gly Ser Phe Pro Ser Leu Ala 
            260                 265                 270         


Val Ala Lys Ile Ile Ile Ile Glu Phe Asn Pro Met Tyr Pro Lys Asp 
        275                 280                 285             


Asn Asp Ile Ala Leu Met Lys Leu Gln Phe Pro Leu Thr Phe Ser Gly 
    290                 295                 300                 


Thr Val Arg Pro Ile Cys Leu Pro Phe Phe Asp Glu Glu Leu Thr Pro 
305                 310                 315                 320 


Ala Thr Pro Leu Trp Ile Ile Gly Trp Gly Phe Thr Lys Gln Asn Gly 
                325                 330                 335     


Gly Lys Met Ser Asp Ile Leu Leu Gln Ala Ser Val Gln Val Ile Asp 
            340                 345                 350         


Ser Thr Arg Cys Asn Ala Asp Asp Ala Tyr Gln Gly Glu Val Thr Glu 
        355                 360                 365             


Lys Met Met Cys Ala Gly Ile Pro Glu Gly Gly Val Asp Thr Cys Gln 
    370                 375                 380                 


Gly Asp Ser Gly Gly Pro Leu Met Tyr Gln Ser Asp Gln Trp His Val 
385                 390                 395                 400 


Val Gly Ile Val Ser Trp Gly Tyr Gly Cys Gly Gly Pro Ser Thr Pro 
                405                 410                 415     


Gly Val Tyr Thr Lys Val Ser Ala Tyr Leu Asn Trp Ile Tyr Asn Val 
            420                 425                 430         


Trp Lys Ala Glu Leu 
        435         


<210>  4593
<211>  1531
<212>  PRT
<213>  Homo sapiens

<400>  4593

Met Ala Leu Arg Gly Phe Cys Ser Ala Asp Gly Ser Asp Pro Leu Trp 
1               5                   10                  15      


Asp Trp Asn Val Thr Trp Asn Thr Ser Asn Pro Asp Phe Thr Lys Cys 
            20                  25                  30          


Phe Gln Asn Thr Val Leu Val Trp Val Pro Cys Phe Tyr Leu Trp Ala 
        35                  40                  45              


Cys Phe Pro Phe Tyr Phe Leu Tyr Leu Ser Arg His Asp Arg Gly Tyr 
    50                  55                  60                  


Ile Gln Met Thr Pro Leu Asn Lys Thr Lys Thr Ala Leu Gly Phe Leu 
65                  70                  75                  80  


Leu Trp Ile Val Cys Trp Ala Asp Leu Phe Tyr Ser Phe Trp Glu Arg 
                85                  90                  95      


Ser Arg Gly Ile Phe Leu Ala Pro Val Phe Leu Val Ser Pro Thr Leu 
            100                 105                 110         


Leu Gly Ile Thr Met Leu Leu Ala Thr Phe Leu Ile Gln Leu Glu Arg 
        115                 120                 125             


Arg Lys Gly Val Gln Ser Ser Gly Ile Met Leu Thr Phe Trp Leu Val 
    130                 135                 140                 


Ala Leu Val Cys Ala Leu Ala Ile Leu Arg Ser Lys Ile Met Thr Ala 
145                 150                 155                 160 


Leu Lys Glu Asp Ala Gln Val Asp Leu Phe Arg Asp Ile Thr Phe Tyr 
                165                 170                 175     


Val Tyr Phe Ser Leu Leu Leu Ile Gln Leu Val Leu Ser Cys Phe Ser 
            180                 185                 190         


Asp Arg Ser Pro Leu Phe Ser Glu Thr Ile His Asp Pro Asn Pro Cys 
        195                 200                 205             


Pro Glu Ser Ser Ala Ser Phe Leu Ser Arg Ile Thr Phe Trp Trp Ile 
    210                 215                 220                 


Thr Gly Leu Ile Val Arg Gly Tyr Arg Gln Pro Leu Glu Gly Ser Asp 
225                 230                 235                 240 


Leu Trp Ser Leu Asn Lys Glu Asp Thr Ser Glu Gln Val Val Pro Val 
                245                 250                 255     


Leu Val Lys Asn Trp Lys Lys Glu Cys Ala Lys Thr Arg Lys Gln Pro 
            260                 265                 270         


Val Lys Val Val Tyr Ser Ser Lys Asp Pro Ala Gln Pro Lys Glu Ser 
        275                 280                 285             


Ser Lys Val Asp Ala Asn Glu Glu Val Glu Ala Leu Ile Val Lys Ser 
    290                 295                 300                 


Pro Gln Lys Glu Trp Asn Pro Ser Leu Phe Lys Val Leu Tyr Lys Thr 
305                 310                 315                 320 


Phe Gly Pro Tyr Phe Leu Met Ser Phe Phe Phe Lys Ala Ile His Asp 
                325                 330                 335     


Leu Met Met Phe Ser Gly Pro Gln Ile Leu Lys Leu Leu Ile Lys Phe 
            340                 345                 350         


Val Asn Asp Thr Lys Ala Pro Asp Trp Gln Gly Tyr Phe Tyr Thr Val 
        355                 360                 365             


Leu Leu Phe Val Thr Ala Cys Leu Gln Thr Leu Val Leu His Gln Tyr 
    370                 375                 380                 


Phe His Ile Cys Phe Val Ser Gly Met Arg Ile Lys Thr Ala Val Ile 
385                 390                 395                 400 


Gly Ala Val Tyr Arg Lys Ala Leu Val Ile Thr Asn Ser Ala Arg Lys 
                405                 410                 415     


Ser Ser Thr Val Gly Glu Ile Val Asn Leu Met Ser Val Asp Ala Gln 
            420                 425                 430         


Arg Phe Met Asp Leu Ala Thr Tyr Ile Asn Met Ile Trp Ser Ala Pro 
        435                 440                 445             


Leu Gln Val Ile Leu Ala Leu Tyr Leu Leu Trp Leu Asn Leu Gly Pro 
    450                 455                 460                 


Ser Val Leu Ala Gly Val Ala Val Met Val Leu Met Val Pro Val Asn 
465                 470                 475                 480 


Ala Val Met Ala Met Lys Thr Lys Thr Tyr Gln Val Ala His Met Lys 
                485                 490                 495     


Ser Lys Asp Asn Arg Ile Lys Leu Met Asn Glu Ile Leu Asn Gly Ile 
            500                 505                 510         


Lys Val Leu Lys Leu Tyr Ala Trp Glu Leu Ala Phe Lys Asp Lys Val 
        515                 520                 525             


Leu Ala Ile Arg Gln Glu Glu Leu Lys Val Leu Lys Lys Ser Ala Tyr 
    530                 535                 540                 


Leu Ser Ala Val Gly Thr Phe Thr Trp Val Cys Thr Pro Phe Leu Val 
545                 550                 555                 560 


Ala Leu Cys Thr Phe Ala Val Tyr Val Thr Ile Asp Glu Asn Asn Ile 
                565                 570                 575     


Leu Asp Ala Gln Thr Ala Phe Val Ser Leu Ala Leu Phe Asn Ile Leu 
            580                 585                 590         


Arg Phe Pro Leu Asn Ile Leu Pro Met Val Ile Ser Ser Ile Val Gln 
        595                 600                 605             


Ala Ser Val Ser Leu Lys Arg Leu Arg Ile Phe Leu Ser His Glu Glu 
    610                 615                 620                 


Leu Glu Pro Asp Ser Ile Glu Arg Arg Pro Val Lys Asp Gly Gly Gly 
625                 630                 635                 640 


Thr Asn Ser Ile Thr Val Arg Asn Ala Thr Phe Thr Trp Ala Arg Ser 
                645                 650                 655     


Asp Pro Pro Thr Leu Asn Gly Ile Thr Phe Ser Ile Pro Glu Gly Ala 
            660                 665                 670         


Leu Val Ala Val Val Gly Gln Val Gly Cys Gly Lys Ser Ser Leu Leu 
        675                 680                 685             


Ser Ala Leu Leu Ala Glu Met Asp Lys Val Glu Gly His Val Ala Ile 
    690                 695                 700                 


Lys Gly Ser Val Ala Tyr Val Pro Gln Gln Ala Trp Ile Gln Asn Asp 
705                 710                 715                 720 


Ser Leu Arg Glu Asn Ile Leu Phe Gly Cys Gln Leu Glu Glu Pro Tyr 
                725                 730                 735     


Tyr Arg Ser Val Ile Gln Ala Cys Ala Leu Leu Pro Asp Leu Glu Ile 
            740                 745                 750         


Leu Pro Ser Gly Asp Arg Thr Glu Ile Gly Glu Lys Gly Val Asn Leu 
        755                 760                 765             


Ser Gly Gly Gln Lys Gln Arg Val Ser Leu Ala Arg Ala Val Tyr Ser 
    770                 775                 780                 


Asn Ala Asp Ile Tyr Leu Phe Asp Asp Pro Leu Ser Ala Val Asp Ala 
785                 790                 795                 800 


His Val Gly Lys His Ile Phe Glu Asn Val Ile Gly Pro Lys Gly Met 
                805                 810                 815     


Leu Lys Asn Lys Thr Arg Ile Leu Val Thr His Ser Met Ser Tyr Leu 
            820                 825                 830         


Pro Gln Val Asp Val Ile Ile Val Met Ser Gly Gly Lys Ile Ser Glu 
        835                 840                 845             


Met Gly Ser Tyr Gln Glu Leu Leu Ala Arg Asp Gly Ala Phe Ala Glu 
    850                 855                 860                 


Phe Leu Arg Thr Tyr Ala Ser Thr Glu Gln Glu Gln Asp Ala Glu Glu 
865                 870                 875                 880 


Asn Gly Val Thr Gly Val Ser Gly Pro Gly Lys Glu Ala Lys Gln Met 
                885                 890                 895     


Glu Asn Gly Met Leu Val Thr Asp Ser Ala Gly Lys Gln Leu Gln Arg 
            900                 905                 910         


Gln Leu Ser Ser Ser Ser Ser Tyr Ser Gly Asp Ile Ser Arg His His 
        915                 920                 925             


Asn Ser Thr Ala Glu Leu Gln Lys Ala Glu Ala Lys Lys Glu Glu Thr 
    930                 935                 940                 


Trp Lys Leu Met Glu Ala Asp Lys Ala Gln Thr Gly Gln Val Lys Leu 
945                 950                 955                 960 


Ser Val Tyr Trp Asp Tyr Met Lys Ala Ile Gly Leu Phe Ile Ser Phe 
                965                 970                 975     


Leu Ser Ile Phe Leu Phe Met Cys Asn His Val Ser Ala Leu Ala Ser 
            980                 985                 990         


Asn Tyr Trp Leu Ser Leu Trp Thr  Asp Asp Pro Ile Val  Asn Gly Thr 
        995                 1000                 1005             


Gln Glu  His Thr Lys Val Arg  Leu Ser Val Tyr Gly  Ala Leu Gly 
    1010                 1015                 1020             


Ile Ser  Gln Gly Ile Ala Val  Phe Gly Tyr Ser Met  Ala Val Ser 
    1025                 1030                 1035             


Ile Gly  Gly Ile Leu Ala Ser  Arg Cys Leu His Val  Asp Leu Leu 
    1040                 1045                 1050             


His Ser  Ile Leu Arg Ser Pro  Met Ser Phe Phe Glu  Arg Thr Pro 
    1055                 1060                 1065             


Ser Gly  Asn Leu Val Asn Arg  Phe Ser Lys Glu Leu  Asp Thr Val 
    1070                 1075                 1080             


Asp Ser  Met Ile Pro Glu Val  Ile Lys Met Phe Met  Gly Ser Leu 
    1085                 1090                 1095             


Phe Asn  Val Ile Gly Ala Cys  Ile Val Ile Leu Leu  Ala Thr Pro 
    1100                 1105                 1110             


Ile Ala  Ala Ile Ile Ile Pro  Pro Leu Gly Leu Ile  Tyr Phe Phe 
    1115                 1120                 1125             


Val Gln  Arg Phe Tyr Val Ala  Ser Ser Arg Gln Leu  Lys Arg Leu 
    1130                 1135                 1140             


Glu Ser  Val Ser Arg Ser Pro  Val Tyr Ser His Phe  Asn Glu Thr 
    1145                 1150                 1155             


Leu Leu  Gly Val Ser Val Ile  Arg Ala Phe Glu Glu  Gln Glu Arg 
    1160                 1165                 1170             


Phe Ile  His Gln Ser Asp Leu  Lys Val Asp Glu Asn  Gln Lys Ala 
    1175                 1180                 1185             


Tyr Tyr  Pro Ser Ile Val Ala  Asn Arg Trp Leu Ala  Val Arg Leu 
    1190                 1195                 1200             


Glu Cys  Val Gly Asn Cys Ile  Val Leu Phe Ala Ala  Leu Phe Ala 
    1205                 1210                 1215             


Val Ile  Ser Arg His Ser Leu  Ser Ala Gly Leu Val  Gly Leu Ser 
    1220                 1225                 1230             


Val Ser  Tyr Ser Leu Gln Val  Thr Thr Tyr Leu Asn  Trp Leu Val 
    1235                 1240                 1245             


Arg Met  Ser Ser Glu Met Glu  Thr Asn Ile Val Ala  Val Glu Arg 
    1250                 1255                 1260             


Leu Lys  Glu Tyr Ser Glu Thr  Glu Lys Glu Ala Pro  Trp Gln Ile 
    1265                 1270                 1275             


Gln Glu  Thr Ala Pro Pro Ser  Ser Trp Pro Gln Val  Gly Arg Val 
    1280                 1285                 1290             


Glu Phe  Arg Asn Tyr Cys Leu  Arg Tyr Arg Glu Asp  Leu Asp Phe 
    1295                 1300                 1305             


Val Leu  Arg His Ile Asn Val  Thr Ile Asn Gly Gly  Glu Lys Val 
    1310                 1315                 1320             


Gly Ile  Val Gly Arg Thr Gly  Ala Gly Lys Ser Ser  Leu Thr Leu 
    1325                 1330                 1335             


Gly Leu  Phe Arg Ile Asn Glu  Ser Ala Glu Gly Glu  Ile Ile Ile 
    1340                 1345                 1350             


Asp Gly  Ile Asn Ile Ala Lys  Ile Gly Leu His Asp  Leu Arg Phe 
    1355                 1360                 1365             


Lys Ile  Thr Ile Ile Pro Gln  Asp Pro Val Leu Phe  Ser Gly Ser 
    1370                 1375                 1380             


Leu Arg  Met Asn Leu Asp Pro  Phe Ser Gln Tyr Ser  Asp Glu Glu 
    1385                 1390                 1395             


Val Trp  Thr Ser Leu Glu Leu  Ala His Leu Lys Asp  Phe Val Ser 
    1400                 1405                 1410             


Ala Leu  Pro Asp Lys Leu Asp  His Glu Cys Ala Glu  Gly Gly Glu 
    1415                 1420                 1425             


Asn Leu  Ser Val Gly Gln Arg  Gln Leu Val Cys Leu  Ala Arg Ala 
    1430                 1435                 1440             


Leu Leu  Arg Lys Thr Lys Ile  Leu Val Leu Asp Glu  Ala Thr Ala 
    1445                 1450                 1455             


Ala Val  Asp Leu Glu Thr Asp  Asp Leu Ile Gln Ser  Thr Ile Arg 
    1460                 1465                 1470             


Thr Gln  Phe Glu Asp Cys Thr  Val Leu Thr Ile Ala  His Arg Leu 
    1475                 1480                 1485             


Asn Thr  Ile Met Asp Tyr Thr  Arg Val Ile Val Leu  Asp Lys Gly 
    1490                 1495                 1500             


Glu Ile  Gln Glu Tyr Gly Ala  Pro Ser Asp Leu Leu  Gln Gln Arg 
    1505                 1510                 1515             


Gly Leu  Phe Tyr Ser Met Ala  Lys Asp Ala Gly Leu  Val 
    1520                 1525                 1530     


<210>  4594
<211>  1531
<212>  PRT
<213>  Homo sapiens

<400>  4594

Met Ala Leu Arg Gly Phe Cys Ser Ala Asp Gly Ser Asp Pro Leu Trp 
1               5                   10                  15      


Asp Trp Asn Val Thr Trp Asn Thr Ser Asn Pro Asp Phe Thr Lys Cys 
            20                  25                  30          


Phe Gln Asn Thr Val Leu Val Trp Val Pro Cys Phe Tyr Leu Trp Ala 
        35                  40                  45              


Cys Phe Pro Phe Tyr Phe Leu Tyr Leu Ser Arg His Asp Arg Gly Tyr 
    50                  55                  60                  


Ile Gln Met Thr Pro Leu Asn Lys Thr Lys Thr Ala Leu Gly Phe Leu 
65                  70                  75                  80  


Leu Trp Ile Val Cys Trp Ala Asp Leu Phe Tyr Ser Phe Trp Glu Arg 
                85                  90                  95      


Ser Arg Gly Ile Phe Leu Ala Pro Val Phe Leu Val Ser Pro Thr Leu 
            100                 105                 110         


Leu Gly Ile Thr Met Leu Leu Ala Thr Phe Leu Ile Gln Leu Glu Arg 
        115                 120                 125             


Arg Lys Gly Val Gln Ser Ser Gly Ile Met Leu Thr Phe Trp Leu Val 
    130                 135                 140                 


Ala Leu Val Cys Ala Leu Ala Ile Leu Arg Ser Lys Ile Met Thr Ala 
145                 150                 155                 160 


Leu Lys Glu Asp Ala Gln Val Asp Leu Phe Arg Asp Ile Thr Phe Tyr 
                165                 170                 175     


Val Tyr Phe Ser Leu Leu Leu Ile Gln Leu Val Leu Ser Cys Phe Ser 
            180                 185                 190         


Asp Arg Ser Pro Leu Phe Ser Glu Thr Ile His Asp Pro Asn Pro Cys 
        195                 200                 205             


Pro Glu Ser Ser Ala Ser Phe Leu Ser Arg Ile Thr Phe Trp Trp Ile 
    210                 215                 220                 


Thr Gly Leu Ile Val Arg Gly Tyr Arg Gln Pro Leu Glu Gly Ser Asp 
225                 230                 235                 240 


Leu Trp Ser Leu Asn Lys Glu Asp Thr Ser Glu Gln Val Val Pro Val 
                245                 250                 255     


Leu Val Lys Asn Trp Lys Lys Glu Cys Ala Lys Thr Arg Lys Gln Pro 
            260                 265                 270         


Val Lys Val Val Tyr Ser Ser Lys Asp Pro Ala Gln Pro Lys Glu Ser 
        275                 280                 285             


Ser Lys Val Asp Ala Asn Glu Glu Val Glu Ala Leu Ile Val Lys Ser 
    290                 295                 300                 


Pro Gln Lys Glu Trp Asn Pro Ser Leu Phe Lys Val Leu Tyr Lys Thr 
305                 310                 315                 320 


Phe Gly Pro Tyr Phe Leu Met Ser Phe Phe Phe Lys Ala Ile His Asp 
                325                 330                 335     


Leu Met Met Phe Ser Gly Pro Gln Ile Leu Lys Leu Leu Ile Lys Phe 
            340                 345                 350         


Val Asn Asp Thr Lys Ala Pro Asp Trp Gln Gly Tyr Phe Tyr Thr Val 
        355                 360                 365             


Leu Leu Phe Val Thr Ala Cys Leu Gln Thr Leu Val Leu His Gln Tyr 
    370                 375                 380                 


Phe His Ile Cys Phe Val Ser Gly Met Arg Ile Lys Thr Ala Val Ile 
385                 390                 395                 400 


Gly Ala Val Tyr Arg Lys Ala Leu Val Ile Thr Asn Ser Ala Arg Lys 
                405                 410                 415     


Ser Ser Thr Val Gly Glu Ile Val Asn Leu Met Ser Val Asp Ala Gln 
            420                 425                 430         


Arg Phe Met Asp Leu Ala Thr Tyr Ile Asn Met Ile Trp Ser Ala Pro 
        435                 440                 445             


Leu Gln Val Ile Leu Ala Leu Tyr Leu Leu Trp Leu Asn Leu Gly Pro 
    450                 455                 460                 


Ser Val Leu Ala Gly Val Ala Val Met Val Leu Met Val Pro Val Asn 
465                 470                 475                 480 


Ala Val Met Ala Met Lys Thr Lys Thr Tyr Gln Val Ala His Met Lys 
                485                 490                 495     


Ser Lys Asp Asn Arg Ile Lys Leu Met Asn Glu Ile Leu Asn Gly Ile 
            500                 505                 510         


Lys Val Leu Lys Leu Tyr Ala Trp Glu Leu Ala Phe Lys Asp Lys Val 
        515                 520                 525             


Leu Ala Ile Arg Gln Glu Glu Leu Lys Val Leu Lys Lys Ser Ala Tyr 
    530                 535                 540                 


Leu Ser Ala Val Gly Thr Phe Thr Trp Val Cys Thr Pro Phe Leu Val 
545                 550                 555                 560 


Ala Leu Cys Thr Phe Ala Val Tyr Val Thr Ile Asp Glu Asn Asn Ile 
                565                 570                 575     


Leu Asp Ala Gln Thr Ala Phe Val Ser Leu Ala Leu Phe Asn Ile Leu 
            580                 585                 590         


Arg Phe Pro Leu Asn Ile Leu Pro Met Val Ile Ser Ser Ile Val Gln 
        595                 600                 605             


Ala Ser Val Ser Leu Lys Arg Leu Arg Ile Phe Leu Ser His Glu Glu 
    610                 615                 620                 


Leu Glu Pro Asp Ser Ile Glu Arg Arg Pro Val Lys Asp Gly Gly Gly 
625                 630                 635                 640 


Thr Asn Ser Ile Thr Val Arg Asn Ala Thr Phe Thr Trp Ala Arg Ser 
                645                 650                 655     


Asp Pro Pro Thr Leu Asn Gly Ile Thr Phe Ser Ile Pro Glu Gly Ala 
            660                 665                 670         


Leu Val Ala Val Val Gly Gln Val Gly Cys Gly Lys Ser Ser Leu Leu 
        675                 680                 685             


Ser Ala Leu Leu Ala Glu Met Asp Lys Val Glu Gly His Val Ala Ile 
    690                 695                 700                 


Lys Gly Ser Val Ala Tyr Val Pro Gln Gln Ala Trp Ile Gln Asn Asp 
705                 710                 715                 720 


Ser Leu Arg Glu Asn Ile Leu Phe Gly Cys Gln Leu Glu Glu Pro Tyr 
                725                 730                 735     


Tyr Arg Ser Val Ile Gln Ala Cys Ala Leu Leu Pro Asp Leu Glu Ile 
            740                 745                 750         


Leu Pro Ser Gly Asp Arg Thr Glu Ile Gly Glu Lys Gly Val Asn Leu 
        755                 760                 765             


Ser Gly Gly Gln Lys Gln Arg Val Ser Leu Ala Arg Ala Val Tyr Ser 
    770                 775                 780                 


Asn Ala Asp Ile Tyr Leu Phe Asp Asp Pro Leu Ser Ala Val Asp Ala 
785                 790                 795                 800 


His Val Gly Lys His Ile Phe Glu Asn Val Ile Gly Pro Lys Gly Met 
                805                 810                 815     


Leu Lys Asn Lys Thr Arg Ile Leu Val Thr His Ser Met Ser Tyr Leu 
            820                 825                 830         


Pro Gln Val Asp Val Ile Ile Val Met Ser Gly Gly Lys Ile Ser Glu 
        835                 840                 845             


Met Gly Ser Tyr Gln Glu Leu Leu Ala Arg Asp Gly Ala Phe Ala Glu 
    850                 855                 860                 


Phe Leu Arg Thr Tyr Ala Ser Thr Glu Gln Glu Gln Asp Ala Glu Glu 
865                 870                 875                 880 


Asn Gly Val Thr Gly Val Ser Gly Pro Gly Lys Glu Ala Lys Gln Met 
                885                 890                 895     


Glu Asn Gly Met Leu Val Thr Asp Ser Ala Gly Lys Gln Leu Gln Arg 
            900                 905                 910         


Gln Leu Ser Ser Ser Ser Ser Tyr Ser Gly Asp Ile Ser Arg His His 
        915                 920                 925             


Asn Ser Thr Ala Glu Leu Gln Lys Ala Glu Ala Lys Lys Glu Glu Thr 
    930                 935                 940                 


Trp Lys Leu Met Glu Ala Asp Lys Ala Gln Thr Gly Gln Val Lys Leu 
945                 950                 955                 960 


Ser Val Tyr Trp Asp Tyr Met Lys Ala Ile Gly Leu Phe Ile Ser Phe 
                965                 970                 975     


Leu Ser Ile Phe Leu Phe Met Cys Asn His Val Ser Ala Leu Ala Ser 
            980                 985                 990         


Asn Tyr Trp Leu Ser Leu Trp Thr  Asp Asp Pro Ile Val  Asn Gly Thr 
        995                 1000                 1005             


Gln Glu  His Thr Lys Val Arg  Leu Ser Val Tyr Gly  Ala Leu Gly 
    1010                 1015                 1020             


Ile Ser  Gln Gly Ile Ala Val  Phe Gly Tyr Ser Met  Ala Val Ser 
    1025                 1030                 1035             


Ile Gly  Gly Ile Leu Ala Ser  Arg Cys Leu His Val  Asp Leu Leu 
    1040                 1045                 1050             


His Ser  Ile Leu Arg Ser Pro  Met Ser Phe Phe Glu  Arg Thr Pro 
    1055                 1060                 1065             


Ser Gly  Asn Leu Val Asn Arg  Phe Ser Lys Glu Leu  Asp Thr Val 
    1070                 1075                 1080             


Asp Ser  Met Ile Pro Glu Val  Ile Lys Met Phe Met  Gly Ser Leu 
    1085                 1090                 1095             


Phe Asn  Val Ile Gly Ala Cys  Ile Val Ile Leu Leu  Ala Thr Pro 
    1100                 1105                 1110             


Ile Ala  Ala Ile Ile Ile Pro  Pro Leu Gly Leu Ile  Tyr Phe Phe 
    1115                 1120                 1125             


Val Gln  Arg Phe Tyr Val Ala  Ser Ser Arg Gln Leu  Lys Arg Leu 
    1130                 1135                 1140             


Glu Ser  Val Ser Arg Ser Pro  Val Tyr Ser His Phe  Asn Glu Thr 
    1145                 1150                 1155             


Leu Leu  Gly Val Ser Val Ile  Arg Ala Phe Glu Glu  Gln Glu Arg 
    1160                 1165                 1170             


Phe Ile  His Gln Ser Asp Leu  Lys Val Asp Glu Asn  Gln Lys Ala 
    1175                 1180                 1185             


Tyr Tyr  Pro Ser Ile Val Ala  Asn Arg Trp Leu Ala  Val Arg Leu 
    1190                 1195                 1200             


Glu Cys  Val Gly Asn Cys Ile  Val Leu Phe Ala Ala  Leu Phe Ala 
    1205                 1210                 1215             


Val Ile  Ser Arg His Ser Leu  Ser Ala Gly Leu Val  Gly Leu Ser 
    1220                 1225                 1230             


Val Ser  Tyr Ser Leu Gln Val  Thr Thr Tyr Leu Asn  Trp Leu Val 
    1235                 1240                 1245             


Arg Met  Ser Ser Glu Met Glu  Thr Asn Ile Val Ala  Val Glu Arg 
    1250                 1255                 1260             


Leu Lys  Glu Tyr Ser Glu Thr  Glu Lys Glu Ala Pro  Trp Gln Ile 
    1265                 1270                 1275             


Gln Glu  Thr Ala Pro Pro Ser  Ser Trp Pro Gln Val  Gly Arg Val 
    1280                 1285                 1290             


Glu Phe  Arg Asn Tyr Cys Leu  Arg Tyr Arg Glu Asp  Leu Asp Phe 
    1295                 1300                 1305             


Val Leu  Arg His Ile Asn Val  Thr Ile Asn Gly Gly  Glu Lys Val 
    1310                 1315                 1320             


Gly Ile  Val Gly Arg Thr Gly  Ala Gly Lys Ser Ser  Leu Thr Leu 
    1325                 1330                 1335             


Gly Leu  Phe Arg Ile Asn Glu  Ser Ala Glu Gly Glu  Ile Ile Ile 
    1340                 1345                 1350             


Asp Gly  Ile Asn Ile Ala Lys  Ile Gly Leu His Asp  Leu Arg Phe 
    1355                 1360                 1365             


Lys Ile  Thr Ile Ile Pro Gln  Asp Pro Val Leu Phe  Ser Gly Ser 
    1370                 1375                 1380             


Leu Arg  Met Asn Leu Asp Pro  Phe Ser Gln Tyr Ser  Asp Glu Glu 
    1385                 1390                 1395             


Val Trp  Thr Ser Leu Glu Leu  Ala His Leu Lys Asp  Phe Val Ser 
    1400                 1405                 1410             


Ala Leu  Pro Asp Lys Leu Asp  His Glu Cys Ala Glu  Gly Gly Glu 
    1415                 1420                 1425             


Asn Leu  Ser Val Gly Gln Arg  Gln Leu Val Cys Leu  Ala Arg Ala 
    1430                 1435                 1440             


Leu Leu  Arg Lys Thr Lys Ile  Leu Val Leu Asp Glu  Ala Thr Ala 
    1445                 1450                 1455             


Ala Val  Asp Leu Glu Thr Asp  Asp Leu Ile Gln Ser  Thr Ile Arg 
    1460                 1465                 1470             


Thr Gln  Phe Glu Asp Cys Thr  Val Leu Thr Ile Ala  His Arg Leu 
    1475                 1480                 1485             


Asn Thr  Ile Met Asp Tyr Thr  Arg Val Ile Val Leu  Asp Lys Gly 
    1490                 1495                 1500             


Glu Ile  Gln Glu Tyr Gly Ala  Pro Ser Asp Leu Leu  Gln Gln Arg 
    1505                 1510                 1515             


Gly Leu  Phe Tyr Ser Met Ala  Lys Asp Ala Gly Leu  Val 
    1520                 1525                 1530     


<210>  4595
<211>  1531
<212>  PRT
<213>  Homo sapiens

<400>  4595

Met Ala Leu Arg Gly Phe Cys Ser Ala Asp Gly Ser Asp Pro Leu Trp 
1               5                   10                  15      


Asp Trp Asn Val Thr Trp Asn Thr Ser Asn Pro Asp Phe Thr Lys Cys 
            20                  25                  30          


Phe Gln Asn Thr Val Leu Val Trp Val Pro Cys Phe Tyr Leu Trp Ala 
        35                  40                  45              


Cys Phe Pro Phe Tyr Phe Leu Tyr Leu Ser Arg His Asp Arg Gly Tyr 
    50                  55                  60                  


Ile Gln Met Thr Pro Leu Asn Lys Thr Lys Thr Ala Leu Gly Phe Leu 
65                  70                  75                  80  


Leu Trp Ile Val Cys Trp Ala Asp Leu Phe Tyr Ser Phe Trp Glu Arg 
                85                  90                  95      


Ser Arg Gly Ile Phe Leu Ala Pro Val Phe Leu Val Ser Pro Thr Leu 
            100                 105                 110         


Leu Gly Ile Thr Met Leu Leu Ala Thr Phe Leu Ile Gln Leu Glu Arg 
        115                 120                 125             


Arg Lys Gly Val Gln Ser Ser Gly Ile Met Leu Thr Phe Trp Leu Val 
    130                 135                 140                 


Ala Leu Val Cys Ala Leu Ala Ile Leu Arg Ser Lys Ile Met Thr Ala 
145                 150                 155                 160 


Leu Lys Glu Asp Ala Gln Val Asp Leu Phe Arg Asp Ile Thr Phe Tyr 
                165                 170                 175     


Val Tyr Phe Ser Leu Leu Leu Ile Gln Leu Val Leu Ser Cys Phe Ser 
            180                 185                 190         


Asp Arg Ser Pro Leu Phe Ser Glu Thr Ile His Asp Pro Asn Pro Cys 
        195                 200                 205             


Pro Glu Ser Ser Ala Ser Phe Leu Ser Arg Ile Thr Phe Trp Trp Ile 
    210                 215                 220                 


Thr Gly Leu Ile Val Arg Gly Tyr Arg Gln Pro Leu Glu Gly Ser Asp 
225                 230                 235                 240 


Leu Trp Ser Leu Asn Lys Glu Asp Thr Ser Glu Gln Val Val Pro Val 
                245                 250                 255     


Leu Val Lys Asn Trp Lys Lys Glu Cys Ala Lys Thr Arg Lys Gln Pro 
            260                 265                 270         


Val Lys Val Val Tyr Ser Ser Lys Asp Pro Ala Gln Pro Lys Glu Ser 
        275                 280                 285             


Ser Lys Val Asp Ala Asn Glu Glu Val Glu Ala Leu Ile Val Lys Ser 
    290                 295                 300                 


Pro Gln Lys Glu Trp Asn Pro Ser Leu Phe Lys Val Leu Tyr Lys Thr 
305                 310                 315                 320 


Phe Gly Pro Tyr Phe Leu Met Ser Phe Phe Phe Lys Ala Ile His Asp 
                325                 330                 335     


Leu Met Met Phe Ser Gly Pro Gln Ile Leu Lys Leu Leu Ile Lys Phe 
            340                 345                 350         


Val Asn Asp Thr Lys Ala Pro Asp Trp Gln Gly Tyr Phe Tyr Thr Val 
        355                 360                 365             


Leu Leu Phe Val Thr Ala Cys Leu Gln Thr Leu Val Leu His Gln Tyr 
    370                 375                 380                 


Phe His Ile Cys Phe Val Ser Gly Met Arg Ile Lys Thr Ala Val Ile 
385                 390                 395                 400 


Gly Ala Val Tyr Arg Lys Ala Leu Val Ile Thr Asn Ser Ala Arg Lys 
                405                 410                 415     


Ser Ser Thr Val Gly Glu Ile Val Asn Leu Met Ser Val Asp Ala Gln 
            420                 425                 430         


Arg Phe Met Asp Leu Ala Thr Tyr Ile Asn Met Ile Trp Ser Ala Pro 
        435                 440                 445             


Leu Gln Val Ile Leu Ala Leu Tyr Leu Leu Trp Leu Asn Leu Gly Pro 
    450                 455                 460                 


Ser Val Leu Ala Gly Val Ala Val Met Val Leu Met Val Pro Val Asn 
465                 470                 475                 480 


Ala Val Met Ala Met Lys Thr Lys Thr Tyr Gln Val Ala His Met Lys 
                485                 490                 495     


Ser Lys Asp Asn Arg Ile Lys Leu Met Asn Glu Ile Leu Asn Gly Ile 
            500                 505                 510         


Lys Val Leu Lys Leu Tyr Ala Trp Glu Leu Ala Phe Lys Asp Lys Val 
        515                 520                 525             


Leu Ala Ile Arg Gln Glu Glu Leu Lys Val Leu Lys Lys Ser Ala Tyr 
    530                 535                 540                 


Leu Ser Ala Val Gly Thr Phe Thr Trp Val Cys Thr Pro Phe Leu Val 
545                 550                 555                 560 


Ala Leu Cys Thr Phe Ala Val Tyr Val Thr Ile Asp Glu Asn Asn Ile 
                565                 570                 575     


Leu Asp Ala Gln Thr Ala Phe Val Ser Leu Ala Leu Phe Asn Ile Leu 
            580                 585                 590         


Arg Phe Pro Leu Asn Ile Leu Pro Met Val Ile Ser Ser Ile Val Gln 
        595                 600                 605             


Ala Ser Val Ser Leu Lys Arg Leu Arg Ile Phe Leu Ser His Glu Glu 
    610                 615                 620                 


Leu Glu Pro Asp Ser Ile Glu Arg Arg Pro Val Lys Asp Gly Gly Gly 
625                 630                 635                 640 


Thr Asn Ser Ile Thr Val Arg Asn Ala Thr Phe Thr Trp Ala Arg Ser 
                645                 650                 655     


Asp Pro Pro Thr Leu Asn Gly Ile Thr Phe Ser Ile Pro Glu Gly Ala 
            660                 665                 670         


Leu Val Ala Val Val Gly Gln Val Gly Cys Gly Lys Ser Ser Leu Leu 
        675                 680                 685             


Ser Ala Leu Leu Ala Glu Met Asp Lys Val Glu Gly His Val Ala Ile 
    690                 695                 700                 


Lys Gly Ser Val Ala Tyr Val Pro Gln Gln Ala Trp Ile Gln Asn Asp 
705                 710                 715                 720 


Ser Leu Arg Glu Asn Ile Leu Phe Gly Cys Gln Leu Glu Glu Pro Tyr 
                725                 730                 735     


Tyr Arg Ser Val Ile Gln Ala Cys Ala Leu Leu Pro Asp Leu Glu Ile 
            740                 745                 750         


Leu Pro Ser Gly Asp Arg Thr Glu Ile Gly Glu Lys Gly Val Asn Leu 
        755                 760                 765             


Ser Gly Gly Gln Lys Gln Arg Val Ser Leu Ala Arg Ala Val Tyr Ser 
    770                 775                 780                 


Asn Ala Asp Ile Tyr Leu Phe Asp Asp Pro Leu Ser Ala Val Asp Ala 
785                 790                 795                 800 


His Val Gly Lys His Ile Phe Glu Asn Val Ile Gly Pro Lys Gly Met 
                805                 810                 815     


Leu Lys Asn Lys Thr Arg Ile Leu Val Thr His Ser Met Ser Tyr Leu 
            820                 825                 830         


Pro Gln Val Asp Val Ile Ile Val Met Ser Gly Gly Lys Ile Ser Glu 
        835                 840                 845             


Met Gly Ser Tyr Gln Glu Leu Leu Ala Arg Asp Gly Ala Phe Ala Glu 
    850                 855                 860                 


Phe Leu Arg Thr Tyr Ala Ser Thr Glu Gln Glu Gln Asp Ala Glu Glu 
865                 870                 875                 880 


Asn Gly Val Thr Gly Val Ser Gly Pro Gly Lys Glu Ala Lys Gln Met 
                885                 890                 895     


Glu Asn Gly Met Leu Val Thr Asp Ser Ala Gly Lys Gln Leu Gln Arg 
            900                 905                 910         


Gln Leu Ser Ser Ser Ser Ser Tyr Ser Gly Asp Ile Ser Arg His His 
        915                 920                 925             


Asn Ser Thr Ala Glu Leu Gln Lys Ala Glu Ala Lys Lys Glu Glu Thr 
    930                 935                 940                 


Trp Lys Leu Met Glu Ala Asp Lys Ala Gln Thr Gly Gln Val Lys Leu 
945                 950                 955                 960 


Ser Val Tyr Trp Asp Tyr Met Lys Ala Ile Gly Leu Phe Ile Ser Phe 
                965                 970                 975     


Leu Ser Ile Phe Leu Phe Met Cys Asn His Val Ser Ala Leu Ala Ser 
            980                 985                 990         


Asn Tyr Trp Leu Ser Leu Trp Thr  Asp Asp Pro Ile Val  Asn Gly Thr 
        995                 1000                 1005             


Gln Glu  His Thr Lys Val Arg  Leu Ser Val Tyr Gly  Ala Leu Gly 
    1010                 1015                 1020             


Ile Ser  Gln Gly Ile Ala Val  Phe Gly Tyr Ser Met  Ala Val Ser 
    1025                 1030                 1035             


Ile Gly  Gly Ile Leu Ala Ser  Arg Cys Leu His Val  Asp Leu Leu 
    1040                 1045                 1050             


His Ser  Ile Leu Arg Ser Pro  Met Ser Phe Phe Glu  Arg Thr Pro 
    1055                 1060                 1065             


Ser Gly  Asn Leu Val Asn Arg  Phe Ser Lys Glu Leu  Asp Thr Val 
    1070                 1075                 1080             


Asp Ser  Met Ile Pro Glu Val  Ile Lys Met Phe Met  Gly Ser Leu 
    1085                 1090                 1095             


Phe Asn  Val Ile Gly Ala Cys  Ile Val Ile Leu Leu  Ala Thr Pro 
    1100                 1105                 1110             


Ile Ala  Ala Ile Ile Ile Pro  Pro Leu Gly Leu Ile  Tyr Phe Phe 
    1115                 1120                 1125             


Val Gln  Arg Phe Tyr Val Ala  Ser Ser Arg Gln Leu  Lys Arg Leu 
    1130                 1135                 1140             


Glu Ser  Val Ser Arg Ser Pro  Val Tyr Ser His Phe  Asn Glu Thr 
    1145                 1150                 1155             


Leu Leu  Gly Val Ser Val Ile  Arg Ala Phe Glu Glu  Gln Glu Arg 
    1160                 1165                 1170             


Phe Ile  His Gln Ser Asp Leu  Lys Val Asp Glu Asn  Gln Lys Ala 
    1175                 1180                 1185             


Tyr Tyr  Pro Ser Ile Val Ala  Asn Arg Trp Leu Ala  Val Arg Leu 
    1190                 1195                 1200             


Glu Cys  Val Gly Asn Cys Ile  Val Leu Phe Ala Ala  Leu Phe Ala 
    1205                 1210                 1215             


Val Ile  Ser Arg His Ser Leu  Ser Ala Gly Leu Val  Gly Leu Ser 
    1220                 1225                 1230             


Val Ser  Tyr Ser Leu Gln Val  Thr Thr Tyr Leu Asn  Trp Leu Val 
    1235                 1240                 1245             


Arg Met  Ser Ser Glu Met Glu  Thr Asn Ile Val Ala  Val Glu Arg 
    1250                 1255                 1260             


Leu Lys  Glu Tyr Ser Glu Thr  Glu Lys Glu Ala Pro  Trp Gln Ile 
    1265                 1270                 1275             


Gln Glu  Thr Ala Pro Pro Ser  Ser Trp Pro Gln Val  Gly Arg Val 
    1280                 1285                 1290             


Glu Phe  Arg Asn Tyr Cys Leu  Arg Tyr Arg Glu Asp  Leu Asp Phe 
    1295                 1300                 1305             


Val Leu  Arg His Ile Asn Val  Thr Ile Asn Gly Gly  Glu Lys Val 
    1310                 1315                 1320             


Gly Ile  Val Gly Arg Thr Gly  Ala Gly Lys Ser Ser  Leu Thr Leu 
    1325                 1330                 1335             


Gly Leu  Phe Arg Ile Asn Glu  Ser Ala Glu Gly Glu  Ile Ile Ile 
    1340                 1345                 1350             


Asp Gly  Ile Asn Ile Ala Lys  Ile Gly Leu His Asp  Leu Arg Phe 
    1355                 1360                 1365             


Lys Ile  Thr Ile Ile Pro Gln  Asp Pro Val Leu Phe  Ser Gly Ser 
    1370                 1375                 1380             


Leu Arg  Met Asn Leu Asp Pro  Phe Ser Gln Tyr Ser  Asp Glu Glu 
    1385                 1390                 1395             


Val Trp  Thr Ser Leu Glu Leu  Ala His Leu Lys Asp  Phe Val Ser 
    1400                 1405                 1410             


Ala Leu  Pro Asp Lys Leu Asp  His Glu Cys Ala Glu  Gly Gly Glu 
    1415                 1420                 1425             


Asn Leu  Ser Val Gly Gln Arg  Gln Leu Val Cys Leu  Ala Arg Ala 
    1430                 1435                 1440             


Leu Leu  Arg Lys Thr Lys Ile  Leu Val Leu Asp Glu  Ala Thr Ala 
    1445                 1450                 1455             


Ala Val  Asp Leu Glu Thr Asp  Asp Leu Ile Gln Ser  Thr Ile Arg 
    1460                 1465                 1470             


Thr Gln  Phe Glu Asp Cys Thr  Val Leu Thr Ile Ala  His Arg Leu 
    1475                 1480                 1485             


Asn Thr  Ile Met Asp Tyr Thr  Arg Val Ile Val Leu  Asp Lys Gly 
    1490                 1495                 1500             


Glu Ile  Gln Glu Tyr Gly Ala  Pro Ser Asp Leu Leu  Gln Gln Arg 
    1505                 1510                 1515             


Gly Leu  Phe Tyr Ser Met Ala  Lys Asp Ala Gly Leu  Val 
    1520                 1525                 1530     


<210>  4596
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  4596

Met Asp Asn Arg Phe Ala Thr Ala Phe Val Ile Ala Cys Val Leu Ser 
1               5                   10                  15      


Leu Ile Ser Thr Ile Tyr Met Ala Ala Ser Ile Gly Thr Asp Phe Trp 
            20                  25                  30          


Tyr Glu Tyr Arg Ser Pro Val Gln Glu Asn Ser Ser Asp Leu Asn Lys 
        35                  40                  45              


Ser Ile Trp Asp Glu Phe Ile Ser Asp Glu Ala Asp Glu Lys Thr Tyr 
    50                  55                  60                  


Asn Asp Ala Leu Phe Arg Tyr Asn Gly Thr Val Gly Leu Trp Arg Arg 
65                  70                  75                  80  


Cys Ile Thr Ile Pro Lys Asn Met His Trp Tyr Ser Pro Pro Glu Arg 
                85                  90                  95      


Thr Glu Ser Phe Asp Val Val Thr Lys Cys Val Ser Phe Thr Leu Thr 
            100                 105                 110         


Glu Gln Phe Met Glu Lys Phe Val Asp Pro Gly Asn His Asn Ser Gly 
        115                 120                 125             


Ile Asp Leu Leu Arg Thr Tyr Leu Trp Arg Cys Gln Phe Leu Leu Pro 
    130                 135                 140                 


Phe Val Ser Leu Gly Leu Met Cys Phe Gly Ala Leu Ile Gly Leu Cys 
145                 150                 155                 160 


Ala Cys Ile Cys Arg Ser Leu Tyr Pro Thr Ile Ala Thr Gly Ile Leu 
                165                 170                 175     


His Leu Leu Ala Gly Leu Cys Thr Leu Gly Ser Val Ser Cys Tyr Val 
            180                 185                 190         


Ala Gly Ile Glu Leu Leu His Gln Lys Leu Glu Leu Pro Asp Asn Val 
        195                 200                 205             


Ser Gly Glu Phe Gly Trp Ser Phe Cys Leu Ala Cys Val Ser Ala Pro 
    210                 215                 220                 


Leu Gln Phe Met Ala Ser Ala Leu Phe Ile Trp Ala Ala His Thr Asn 
225                 230                 235                 240 


Arg Lys Glu Tyr Thr Leu Met Lys Ala Tyr Arg Val Ala 
                245                 250             


<210>  4597
<211>  1555
<212>  PRT
<213>  Homo sapiens

<400>  4597

Met Gly Cys Lys Gly Asp Ala Ser Gly Ala Cys Ala Ala Gly Ala Leu 
1               5                   10                  15      


Pro Val Thr Gly Val Cys Tyr Lys Met Gly Val Leu Val Val Leu Thr 
            20                  25                  30          


Val Leu Trp Leu Phe Ser Ser Val Lys Ala Asp Ser Lys Ala Ile Thr 
        35                  40                  45              


Thr Ser Leu Thr Thr Lys Trp Phe Ser Thr Pro Leu Leu Leu Glu Ala 
    50                  55                  60                  


Ser Glu Phe Leu Ala Glu Asp Ser Gln Glu Lys Phe Trp Asn Phe Val 
65                  70                  75                  80  


Glu Ala Ser Gln Asn Ile Gly Ser Ser Asp His Asp Gly Thr Asp Tyr 
                85                  90                  95      


Ser Tyr Tyr His Ala Ile Leu Glu Ala Ala Phe Gln Phe Leu Ser Pro 
            100                 105                 110         


Leu Gln Gln Asn Leu Phe Lys Phe Cys Leu Ser Leu Arg Ser Tyr Ser 
        115                 120                 125             


Ala Thr Ile Gln Ala Phe Gln Gln Ile Ala Ala Asp Glu Pro Pro Pro 
    130                 135                 140                 


Glu Gly Cys Asn Ser Phe Phe Ser Val His Gly Lys Lys Thr Cys Glu 
145                 150                 155                 160 


Ser Asp Thr Leu Glu Ala Leu Leu Leu Thr Ala Ser Glu Arg Pro Lys 
                165                 170                 175     


Pro Leu Leu Phe Lys Gly Asp His Arg Tyr Pro Ser Ser Asn Pro Glu 
            180                 185                 190         


Ser Pro Val Val Ile Phe Tyr Ser Glu Ile Gly Ser Glu Glu Phe Ser 
        195                 200                 205             


Asn Phe His Arg Gln Leu Ile Ser Lys Ser Asn Ala Gly Lys Ile Asn 
    210                 215                 220                 


Tyr Val Phe Arg His Tyr Ile Phe Asn Pro Arg Lys Glu Pro Val Tyr 
225                 230                 235                 240 


Leu Ser Gly Tyr Gly Val Glu Leu Ala Ile Lys Ser Thr Glu Tyr Lys 
                245                 250                 255     


Ala Lys Asp Asp Thr Gln Val Lys Gly Thr Glu Val Asn Thr Thr Val 
            260                 265                 270         


Ile Gly Glu Asn Asp Pro Ile Asp Glu Val Gln Gly Phe Leu Phe Gly 
        275                 280                 285             


Lys Leu Arg Asp Leu His Pro Asp Leu Glu Gly Gln Leu Lys Glu Leu 
    290                 295                 300                 


Arg Lys His Leu Val Glu Ser Thr Asn Glu Met Ala Pro Leu Lys Val 
305                 310                 315                 320 


Trp Gln Leu Gln Asp Leu Ser Phe Gln Thr Ala Ala Arg Ile Leu Ala 
                325                 330                 335     


Ser Pro Val Glu Leu Ala Leu Val Val Met Lys Asp Leu Ser Gln Asn 
            340                 345                 350         


Phe Pro Thr Lys Ala Arg Ala Ile Thr Lys Thr Ala Val Ser Ser Glu 
        355                 360                 365             


Leu Arg Thr Glu Val Glu Glu Asn Gln Lys Tyr Phe Lys Gly Thr Leu 
    370                 375                 380                 


Gly Leu Gln Pro Gly Asp Ser Ala Leu Phe Ile Asn Gly Leu His Met 
385                 390                 395                 400 


Asp Leu Asp Thr Gln Asp Ile Phe Ser Leu Phe Asp Val Leu Arg Asn 
                405                 410                 415     


Glu Ala Arg Val Met Glu Gly Leu His Arg Leu Gly Ile Glu Gly Leu 
            420                 425                 430         


Ser Leu His Asn Val Leu Lys Leu Asn Ile Gln Pro Ser Glu Ala Asp 
        435                 440                 445             


Tyr Ala Val Asp Ile Arg Ser Pro Ala Ile Ser Trp Val Asn Asn Leu 
    450                 455                 460                 


Glu Val Asp Ser Arg Tyr Asn Ser Trp Pro Ser Ser Leu Gln Glu Leu 
465                 470                 475                 480 


Leu Arg Pro Thr Phe Pro Gly Val Ile Arg Gln Ile Arg Lys Asn Leu 
                485                 490                 495     


His Asn Met Val Phe Ile Val Asp Pro Ala His Glu Thr Thr Ala Glu 
            500                 505                 510         


Leu Met Asn Thr Ala Glu Met Phe Leu Ser Asn His Ile Pro Leu Arg 
        515                 520                 525             


Ile Gly Phe Ile Phe Val Val Asn Asp Ser Glu Asp Val Asp Gly Met 
    530                 535                 540                 


Gln Asp Ala Gly Val Ala Val Leu Arg Ala Tyr Asn Tyr Val Ala Gln 
545                 550                 555                 560 


Glu Val Asp Asp Tyr His Ala Phe Gln Thr Leu Thr His Ile Tyr Asn 
                565                 570                 575     


Lys Val Arg Thr Gly Glu Lys Val Lys Val Glu His Val Val Ser Val 
            580                 585                 590         


Leu Glu Lys Lys Tyr Pro Tyr Val Glu Val Asn Ser Ile Leu Gly Ile 
        595                 600                 605             


Asp Ser Ala Tyr Asp Arg Asn Arg Lys Glu Ala Arg Gly Tyr Tyr Glu 
    610                 615                 620                 


Gln Thr Gly Val Gly Pro Leu Pro Val Val Leu Phe Asn Gly Met Pro 
625                 630                 635                 640 


Phe Glu Arg Glu Gln Leu Asp Pro Asp Glu Leu Glu Thr Ile Thr Met 
                645                 650                 655     


His Lys Ile Leu Glu Thr Thr Thr Phe Phe Gln Arg Ala Val Tyr Leu 
            660                 665                 670         


Gly Glu Leu Pro His Asp Gln Asp Val Val Glu Tyr Ile Met Asn Gln 
        675                 680                 685             


Pro Asn Val Val Pro Arg Ile Asn Ser Arg Ile Leu Thr Ala Glu Arg 
    690                 695                 700                 


Asp Tyr Leu Asp Leu Thr Ala Ser Asn Asn Phe Phe Val Asp Asp Tyr 
705                 710                 715                 720 


Ala Arg Phe Thr Ile Leu Asp Ser Gln Gly Lys Thr Ala Ala Val Ala 
                725                 730                 735     


Asn Ser Met Asn Tyr Leu Thr Lys Lys Gly Met Ser Ser Lys Glu Ile 
            740                 745                 750         


Tyr Asp Asp Ser Phe Ile Arg Pro Val Thr Phe Trp Ile Val Gly Asp 
        755                 760                 765             


Phe Asp Ser Pro Ser Gly Arg Gln Leu Leu Tyr Asp Ala Ile Lys His 
    770                 775                 780                 


Gln Lys Ser Ser Asn Asn Val Arg Ile Ser Met Ile Asn Asn Pro Ala 
785                 790                 795                 800 


Lys Glu Ile Ser Tyr Glu Asn Thr Gln Ile Ser Arg Ala Ile Trp Ala 
                805                 810                 815     


Ala Leu Gln Thr Gln Thr Ser Asn Ala Ala Lys Asn Phe Ile Thr Lys 
            820                 825                 830         


Met Ala Lys Glu Gly Ala Ala Glu Ala Leu Ala Ala Gly Ala Asp Ile 
        835                 840                 845             


Ala Glu Phe Ser Val Gly Gly Met Asp Phe Ser Leu Phe Lys Glu Val 
    850                 855                 860                 


Phe Glu Ser Ser Lys Met Asp Phe Ile Leu Ser His Ala Val Tyr Cys 
865                 870                 875                 880 


Arg Asp Val Leu Lys Leu Lys Lys Gly Gln Arg Ala Val Ile Ser Asn 
                885                 890                 895     


Gly Arg Ile Ile Gly Pro Leu Glu Asp Ser Glu Leu Phe Asn Gln Asp 
            900                 905                 910         


Asp Phe His Leu Leu Glu Asn Ile Ile Leu Lys Thr Ser Gly Gln Lys 
        915                 920                 925             


Ile Lys Ser His Ile Gln Gln Leu Arg Val Glu Glu Asp Val Ala Ser 
    930                 935                 940                 


Asp Leu Val Met Lys Val Asp Ala Leu Leu Ser Ala Gln Pro Lys Gly 
945                 950                 955                 960 


Asp Pro Arg Ile Glu Tyr Gln Phe Phe Glu Asp Arg His Ser Ala Ile 
                965                 970                 975     


Lys Leu Arg Pro Lys Glu Gly Glu Thr Tyr Phe Asp Val Val Ala Val 
            980                 985                 990         


Val Asp Pro Val Thr Arg Glu Ala  Gln Arg Leu Ala Pro  Leu Leu Leu 
        995                 1000                 1005             


Val Leu  Ala Gln Leu Ile Asn  Met Asn Leu Arg Val  Phe Met Asn 
    1010                 1015                 1020             


Cys Gln  Ser Lys Leu Ser Asp  Met Pro Leu Lys Ser  Phe Tyr Arg 
    1025                 1030                 1035             


Tyr Val  Leu Glu Pro Glu Ile  Ser Phe Thr Ser Asp  Asn Ser Phe 
    1040                 1045                 1050             


Ala Lys  Gly Pro Ile Ala Lys  Phe Leu Asp Met Pro  Gln Ser Pro 
    1055                 1060                 1065             


Leu Phe  Thr Leu Asn Leu Asn  Thr Pro Glu Ser Trp  Met Val Glu 
    1070                 1075                 1080             


Ser Val  Arg Thr Pro Tyr Asp  Leu Asp Asn Ile Tyr  Leu Glu Glu 
    1085                 1090                 1095             


Val Asp  Ser Val Val Ala Ala  Glu Tyr Glu Leu Glu  Tyr Leu Leu 
    1100                 1105                 1110             


Leu Glu  Gly His Cys Tyr Asp  Ile Thr Thr Gly Gln  Pro Pro Arg 
    1115                 1120                 1125             


Gly Leu  Gln Phe Thr Leu Gly  Thr Ser Ala Asn Pro  Val Ile Val 
    1130                 1135                 1140             


Asp Thr  Ile Val Met Ala Asn  Leu Gly Tyr Phe Gln  Leu Lys Ala 
    1145                 1150                 1155             


Asn Pro  Gly Ala Trp Ile Leu  Arg Leu Arg Lys Gly  Arg Ser Glu 
    1160                 1165                 1170             


Asp Ile  Tyr Arg Ile Tyr Ser  His Asp Gly Thr Asp  Ser Pro Pro 
    1175                 1180                 1185             


Asp Ala  Asp Glu Val Val Ile  Val Leu Asn Asn Phe  Lys Ser Lys 
    1190                 1195                 1200             


Ile Ile  Lys Val Lys Val Gln  Lys Lys Ala Asp Met  Val Asn Glu 
    1205                 1210                 1215             


Asp Leu  Leu Ser Asp Gly Thr  Ser Glu Asn Glu Ser  Gly Phe Trp 
    1220                 1225                 1230             


Asp Ser  Phe Lys Trp Gly Phe  Thr Gly Gln Lys Thr  Glu Glu Val 
    1235                 1240                 1245             


Lys Gln  Asp Lys Asp Asp Ile  Ile Asn Ile Phe Ser  Val Ala Ser 
    1250                 1255                 1260             


Gly His  Leu Tyr Glu Arg Phe  Leu Arg Ile Met Met  Leu Ser Val 
    1265                 1270                 1275             


Leu Lys  Asn Thr Lys Thr Pro  Val Lys Phe Trp Phe  Leu Lys Asn 
    1280                 1285                 1290             


Tyr Leu  Ser Pro Thr Phe Lys  Glu Phe Ile Pro Tyr  Met Ala Asn 
    1295                 1300                 1305             


Glu Tyr  Asn Phe Gln Tyr Glu  Leu Val Gln Tyr Lys  Trp Pro Arg 
    1310                 1315                 1320             


Trp Leu  His Gln Gln Thr Glu  Lys Gln Arg Ile Ile  Trp Gly Tyr 
    1325                 1330                 1335             


Lys Ile  Leu Phe Leu Asp Val  Leu Phe Pro Leu Val  Val Asp Lys 
    1340                 1345                 1350             


Phe Leu  Phe Val Asp Ala Asp  Gln Ile Val Arg Thr  Asp Leu Lys 
    1355                 1360                 1365             


Glu Leu  Arg Asp Phe Asn Leu  Asp Gly Ala Pro Tyr  Gly Tyr Thr 
    1370                 1375                 1380             


Pro Phe  Cys Asp Ser Arg Arg  Glu Met Asp Gly Tyr  Arg Phe Trp 
    1385                 1390                 1395             


Lys Ser  Gly Tyr Trp Ala Ser  His Leu Ala Gly Arg  Lys Tyr His 
    1400                 1405                 1410             


Ile Ser  Ala Leu Tyr Val Val  Asp Leu Lys Lys Phe  Arg Lys Ile 
    1415                 1420                 1425             


Ala Ala  Gly Asp Arg Leu Arg  Gly Gln Tyr Gln Gly  Leu Ser Gln 
    1430                 1435                 1440             


Asp Pro  Asn Ser Leu Ser Asn  Leu Asp Gln Asp Leu  Pro Asn Asn 
    1445                 1450                 1455             


Met Ile  His Gln Val Pro Ile  Lys Ser Leu Pro Gln  Glu Trp Leu 
    1460                 1465                 1470             


Trp Cys  Glu Thr Trp Cys Asp  Asp Ala Ser Lys Lys  Arg Ala Lys 
    1475                 1480                 1485             


Thr Ile  Asp Leu Cys Asn Asn  Pro Met Thr Lys Glu  Pro Lys Leu 
    1490                 1495                 1500             


Glu Ala  Ala Val Arg Ile Val  Pro Glu Trp Gln Asp  Tyr Asp Gln 
    1505                 1510                 1515             


Glu Ile  Lys Gln Leu Gln Ile  Arg Phe Gln Lys Glu  Lys Glu Thr 
    1520                 1525                 1530             


Gly Ala  Leu Tyr Lys Glu Lys  Thr Lys Glu Pro Ser  Arg Glu Gly 
    1535                 1540                 1545             


Pro Gln  Lys Arg Glu Glu Leu  
    1550                 1555 


<210>  4598
<211>  589
<212>  PRT
<213>  Homo sapiens

<400>  4598

Met Arg Pro Leu Pro Gly Ala Leu Gly Val Ala Ala Ala Ala Ala Leu 
1               5                   10                  15      


Trp Leu Leu Leu Leu Leu Leu Pro Arg Thr Arg Ala Asp Glu His Glu 
            20                  25                  30          


His Thr Tyr Gln Asp Lys Glu Glu Val Val Leu Trp Met Asn Thr Val 
        35                  40                  45              


Gly Pro Tyr His Asn Arg Gln Glu Thr Tyr Lys Tyr Phe Ser Leu Pro 
    50                  55                  60                  


Phe Cys Val Gly Ser Lys Lys Ser Ile Ser His Tyr His Glu Thr Leu 
65                  70                  75                  80  


Gly Glu Ala Leu Gln Gly Val Glu Leu Glu Phe Ser Gly Leu Asp Ile 
                85                  90                  95      


Lys Phe Lys Asp Asp Val Met Pro Ala Thr Tyr Cys Glu Ile Asp Leu 
            100                 105                 110         


Asp Lys Glu Lys Arg Asp Ala Phe Val Tyr Ala Ile Lys Asn His Tyr 
        115                 120                 125             


Trp Tyr Gln Met Tyr Ile Asp Asp Leu Pro Ile Trp Gly Ile Val Gly 
    130                 135                 140                 


Glu Ala Asp Glu Asn Gly Glu Asp Tyr Tyr Leu Trp Thr Tyr Lys Lys 
145                 150                 155                 160 


Leu Glu Ile Gly Phe Asn Gly Asn Arg Ile Val Asp Val Asn Leu Thr 
                165                 170                 175     


Ser Glu Gly Lys Val Lys Leu Val Pro Asn Thr Lys Ile Gln Met Ser 
            180                 185                 190         


Tyr Ser Val Lys Trp Lys Lys Ser Asp Val Lys Phe Glu Asp Arg Phe 
        195                 200                 205             


Asp Lys Tyr Leu Asp Pro Ser Phe Phe Gln His Arg Ile His Trp Phe 
    210                 215                 220                 


Ser Ile Phe Asn Ser Phe Met Met Val Ile Phe Leu Val Gly Leu Val 
225                 230                 235                 240 


Ser Met Ile Leu Met Arg Thr Leu Arg Lys Asp Tyr Ala Arg Tyr Ser 
                245                 250                 255     


Lys Glu Glu Glu Met Asp Asp Met Asp Arg Asp Leu Gly Asp Glu Tyr 
            260                 265                 270         


Gly Trp Lys Gln Val His Gly Asp Val Phe Arg Pro Ser Ser His Pro 
        275                 280                 285             


Leu Ile Phe Ser Ser Leu Ile Gly Ser Gly Cys Gln Ile Phe Ala Val 
    290                 295                 300                 


Ser Leu Ile Val Ile Ile Val Ala Met Ile Glu Asp Leu Tyr Thr Glu 
305                 310                 315                 320 


Arg Gly Ser Met Leu Ser Thr Ala Ile Phe Val Tyr Ala Ala Thr Ser 
                325                 330                 335     


Pro Val Asn Gly Tyr Phe Gly Gly Ser Leu Tyr Ala Arg Gln Gly Gly 
            340                 345                 350         


Arg Arg Trp Ile Lys Gln Met Phe Ile Gly Ala Phe Leu Ile Pro Ala 
        355                 360                 365             


Met Val Cys Gly Thr Ala Phe Phe Ile Asn Phe Ile Ala Ile Tyr Tyr 
    370                 375                 380                 


His Ala Ser Arg Ala Ile Pro Phe Gly Thr Met Val Ala Val Cys Cys 
385                 390                 395                 400 


Ile Cys Phe Phe Val Ile Leu Pro Leu Asn Leu Val Gly Thr Ile Leu 
                405                 410                 415     


Gly Arg Asn Leu Ser Gly Gln Pro Asn Phe Pro Cys Arg Val Asn Ala 
            420                 425                 430         


Val Pro Arg Pro Ile Pro Glu Lys Lys Trp Phe Met Glu Pro Ala Val 
        435                 440                 445             


Ile Val Cys Leu Gly Gly Ile Leu Pro Phe Gly Ser Ile Phe Ile Glu 
    450                 455                 460                 


Met Tyr Phe Ile Phe Thr Ser Phe Trp Ala Tyr Lys Ile Tyr Tyr Val 
465                 470                 475                 480 


Tyr Gly Phe Met Met Leu Val Leu Val Ile Leu Cys Ile Val Thr Val 
                485                 490                 495     


Cys Val Thr Ile Val Cys Thr Tyr Phe Leu Leu Asn Ala Glu Asp Tyr 
            500                 505                 510         


Arg Trp Gln Trp Thr Ser Phe Leu Ser Ala Ala Ser Thr Ala Ile Tyr 
        515                 520                 525             


Val Tyr Met Tyr Ser Phe Tyr Tyr Tyr Phe Phe Lys Thr Lys Met Tyr 
    530                 535                 540                 


Gly Leu Phe Gln Thr Ser Phe Tyr Phe Gly Tyr Met Ala Val Phe Ser 
545                 550                 555                 560 


Thr Ala Leu Gly Ile Met Cys Gly Ala Ile Gly Tyr Met Gly Thr Ser 
                565                 570                 575     


Ala Phe Val Arg Lys Ile Tyr Thr Asn Val Lys Ile Asp 
            580                 585                 


<210>  4599
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  4599

Met Val Met Arg Pro Leu Trp Ser Leu Leu Leu Trp Glu Ala Leu Leu 
1               5                   10                  15      


Pro Ile Thr Val Thr Gly Ala Gln Val Leu Ser Lys Val Gly Gly Ser 
            20                  25                  30          


Val Leu Leu Val Ala Ala Arg Pro Pro Gly Phe Gln Val Arg Glu Ala 
        35                  40                  45              


Ile Trp Arg Ser Leu Trp Pro Ser Glu Glu Leu Leu Ala Thr Phe Phe 
    50                  55                  60                  


Arg Gly Ser Leu Glu Thr Leu Tyr His Ser Arg Phe Leu Gly Arg Ala 
65                  70                  75                  80  


Gln Leu His Ser Asn Leu Ser Leu Glu Leu Gly Pro Leu Glu Ser Gly 
                85                  90                  95      


Asp Ser Gly Asn Phe Ser Val Leu Met Val Asp Thr Arg Gly Gln Pro 
            100                 105                 110         


Trp Thr Gln Thr Leu Gln Leu Lys Val Tyr Asp Ala Val Pro Arg Pro 
        115                 120                 125             


Val Val Gln Val Phe Ile Ala Val Glu Arg Asp Ala Gln Pro Ser Lys 
    130                 135                 140                 


Thr Cys Gln Val Phe Leu Ser Cys Trp Ala Pro Asn Ile Ser Glu Ile 
145                 150                 155                 160 


Thr Tyr Ser Trp Arg Arg Glu Thr Thr Met Asp Phe Gly Met Glu Pro 
                165                 170                 175     


His Ser Leu Phe Thr Asp Gly Gln Val Leu Ser Ile Ser Leu Gly Pro 
            180                 185                 190         


Gly Asp Arg Asp Val Ala Tyr Ser Cys Ile Val Ser Asn Pro Val Ser 
        195                 200                 205             


Trp Asp Leu Ala Thr Val Thr Pro Trp Asp Ser Cys His His Glu Ala 
    210                 215                 220                 


Ala Pro Gly Lys Ala Ser Tyr Lys Asp Val Leu Leu Val Val Val Pro 
225                 230                 235                 240 


Val Ser Leu Leu Leu Met Leu Val Thr Leu Phe Ser Ala Trp His Trp 
                245                 250                 255     


Cys Pro Cys Ser Gly Lys Lys Lys Lys Asp Val His Ala Asp Arg Val 
            260                 265                 270         


Gly Pro Glu Thr Glu Asn Pro Leu Val Gln Asp Leu Pro 
        275                 280                 285 


<210>  4600
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  4600

Met Pro Val Arg Phe Lys Gly Leu Ser Glu Tyr Gln Arg Asn Phe Leu 
1               5                   10                  15      


Trp Lys Lys Ser Tyr Leu Ser Glu Ser Cys Asn Ser Ser Val Gly Arg 
            20                  25                  30          


Lys Tyr Pro Trp Ala Gly Leu Arg Ser Asp Gln Leu Gly Ile Thr Lys 
        35                  40                  45              


Glu Pro Ser Phe Ile Ser Lys Arg Arg Val Pro Tyr His Asp Pro Gln 
    50                  55                  60                  


Ile Ser Lys Ser Leu Glu Trp Asn Gly Ala Ile Ser Glu Ser Asn Val 
65                  70                  75                  80  


Val Ala Ser Pro Glu Pro Glu Ala Pro Glu Thr Pro Lys Ser Gln Glu 
                85                  90                  95      


Ala Glu Gln Lys Asp Val Thr Gln Glu Arg Val His Ser Leu Glu Ala 
            100                 105                 110         


Ser Arg Val Pro Lys Arg Thr Arg Ser His Ser Ala Asp Ser Arg Ala 
        115                 120                 125             


Glu Gly Ala Ser Asp Val Glu Asn Asn Glu Gly Val Thr Asn His Thr 
    130                 135                 140                 


Pro Val Asn Glu Asn Val Glu Leu Glu His Ser Thr Lys Val Leu Ser 
145                 150                 155                 160 


Glu Asn Val Asp Asn Gly Val Gly Ile Phe Thr Ala Phe Leu Phe Lys 
                165                 170                 175     


Ser Ile Glu Phe Phe Ile Gly Phe Ile Val Ile Ser Val Ile Leu His 
            180                 185                 190         


Phe Val Phe Gln Asn Phe Pro Leu Leu Phe Ser Cys Leu Met Ser Ile 
        195                 200                 205             


Arg Ile Val Asp Asn Arg Leu Leu Thr Leu Val Ile Val Asn 
    210                 215                 220         


<210>  4601
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  4601

Met Gly Leu Leu Ala Phe Leu Lys Thr Gln Phe Val Leu His Leu Leu 
1               5                   10                  15      


Val Gly Phe Val Phe Val Val Ser Gly Leu Val Ile Asn Phe Val Gln 
            20                  25                  30          


Leu Cys Thr Leu Ala Leu Trp Pro Val Ser Lys Gln Leu Tyr Arg Arg 
        35                  40                  45              


Leu Asn Cys Arg Leu Ala Tyr Ser Leu Trp Ser Gln Leu Val Met Leu 
    50                  55                  60                  


Leu Glu Trp Trp Ser Cys Thr Glu Cys Thr Leu Phe Thr Asp Gln Ala 
65                  70                  75                  80  


Thr Val Glu Arg Phe Gly Lys Glu His Ala Val Ile Ile Leu Asn His 
                85                  90                  95      


Asn Phe Glu Ile Asp Phe Leu Cys Gly Trp Thr Met Cys Glu Arg Phe 
            100                 105                 110         


Gly Val Leu Gly Ser Ser Lys Val Leu Ala Lys Lys Glu Leu Leu Tyr 
        115                 120                 125             


Val Pro Leu Ile Gly Trp Thr Trp Tyr Phe Leu Glu Ile Val Phe Cys 
    130                 135                 140                 


Lys Arg Lys Trp Glu Glu Asp Arg Asp Thr Val Val Glu Gly Leu Arg 
145                 150                 155                 160 


Arg Leu Ser Asp Tyr Pro Glu Tyr Met Trp Phe Leu Leu Tyr Cys Glu 
                165                 170                 175     


Gly Thr Arg Phe Thr Glu Thr Lys His Arg Val Ser Met Glu Val Ala 
            180                 185                 190         


Ala Ala Lys Gly Leu Pro Val Leu Lys Tyr His Leu Leu Pro Arg Thr 
        195                 200                 205             


Lys Gly Phe Thr Thr Ala Val Lys Cys Leu Arg Gly Thr Val Ala Ala 
    210                 215                 220                 


Val Tyr Asp Val Thr Leu Asn Phe Arg Gly Asn Lys Asn Pro Ser Leu 
225                 230                 235                 240 


Leu Gly Ile Leu Tyr Gly Lys Lys Tyr Glu Ala Asp Met Cys Val Arg 
                245                 250                 255     


Arg Phe Pro Leu Glu Asp Ile Pro Leu Asp Glu Lys Glu Ala Ala Gln 
            260                 265                 270         


Trp Leu His Lys Leu Tyr Gln Glu Lys Asp Ala Leu Gln Glu Ile Tyr 
        275                 280                 285             


Asn Gln Lys Gly Met Phe Pro Gly Glu Gln Phe Lys Pro Ala Arg Arg 
    290                 295                 300                 


Pro Trp Thr Leu Leu Asn Phe Leu Ser Trp Ala Thr Ile Leu Leu Ser 
305                 310                 315                 320 


Pro Leu Phe Ser Phe Val Leu Gly Val Phe Ala Ser Gly Ser Pro Leu 
                325                 330                 335     


Leu Ile Leu Thr Phe Leu Gly Phe Val Gly Ala Ala Ser Phe Gly Val 
            340                 345                 350         


Arg Arg Leu Ile Gly Val Thr Glu Ile Glu Lys Gly Ser Ser Tyr Gly 
        355                 360                 365             


Asn Gln Glu Phe Lys Lys Lys Glu 
    370                 375     


<210>  4602
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  4602

Met Asp Leu Ala Gly Leu Leu Lys Ser Gln Phe Leu Cys His Leu Val 
1               5                   10                  15      


Phe Cys Tyr Val Phe Ile Ala Ser Gly Leu Ile Ile Asn Thr Ile Gln 
            20                  25                  30          


Leu Phe Thr Leu Leu Leu Trp Pro Ile Asn Lys Gln Leu Phe Arg Lys 
        35                  40                  45              


Ile Asn Cys Arg Leu Ser Tyr Cys Ile Ser Ser Gln Leu Val Met Leu 
    50                  55                  60                  


Leu Glu Trp Trp Ser Gly Thr Glu Cys Thr Ile Phe Thr Asp Pro Arg 
65                  70                  75                  80  


Ala Tyr Leu Lys Tyr Gly Lys Glu Asn Ala Ile Val Val Leu Asn His 
                85                  90                  95      


Lys Phe Glu Ile Asp Phe Leu Cys Gly Trp Ser Leu Ser Glu Arg Phe 
            100                 105                 110         


Gly Leu Leu Gly Gly Ser Lys Val Leu Ala Lys Lys Glu Leu Ala Tyr 
        115                 120                 125             


Val Pro Ile Ile Gly Trp Met Trp Tyr Phe Thr Glu Met Val Phe Cys 
    130                 135                 140                 


Ser Arg Lys Trp Glu Gln Asp Arg Lys Thr Val Ala Thr Ser Leu Gln 
145                 150                 155                 160 


His Leu Arg Asp Tyr Pro Glu Lys Tyr Phe Phe Leu Ile His Cys Glu 
                165                 170                 175     


Gly Thr Arg Phe Thr Glu Lys Lys His Glu Ile Ser Met Gln Val Ala 
            180                 185                 190         


Arg Ala Lys Gly Leu Pro Arg Leu Lys His His Leu Leu Pro Arg Thr 
        195                 200                 205             


Lys Gly Phe Ala Ile Thr Val Arg Ser Leu Arg Asn Val Val Ser Ala 
    210                 215                 220                 


Val Tyr Asp Cys Thr Leu Asn Phe Arg Asn Asn Glu Asn Pro Thr Leu 
225                 230                 235                 240 


Leu Gly Val Leu Asn Gly Lys Lys Tyr His Ala Asp Leu Tyr Val Arg 
                245                 250                 255     


Arg Ile Pro Leu Glu Asp Ile Pro Glu Asp Asp Asp Glu Cys Ser Ala 
            260                 265                 270         


Trp Leu His Lys Leu Tyr Gln Glu Lys Asp Ala Phe Gln Glu Glu Tyr 
        275                 280                 285             


Tyr Arg Thr Gly Thr Phe Pro Glu Thr Pro Met Val Pro Pro Arg Arg 
    290                 295                 300                 


Pro Trp Thr Leu Val Asn Trp Leu Phe Trp Ala Ser Leu Val Leu Tyr 
305                 310                 315                 320 


Pro Phe Phe Gln Phe Leu Val Ser Met Ile Arg Ser Gly Ser Ser Leu 
                325                 330                 335     


Thr Leu Ala Ser Phe Ile Leu Val Phe Phe Val Ala Ser Val Gly Val 
            340                 345                 350         


Arg Trp Met Ile Gly Val Thr Glu Ile Asp Lys Gly Ser Ala Tyr Gly 
        355                 360                 365             


Asn Ser Asp Ser Lys Gln Lys Leu Asn Asp 
    370                 375             


<210>  4603
<211>  31
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be any naturally occurring amino acid

<400>  4603

Ala Leu Pro His Ala Ser Asx Cys Met Pro Leu Glu Xaa Ser Asx Asn 
1               5                   10                  15      


Ile Thr Leu Ile Lys Glu His Met Ser Ala Pro Ile Glu Asn Ser 
            20                  25                  30      


<210>  4604
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  4604

Met Ala Ala Ala Leu Trp Gly Phe Phe Pro Val Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ser Gly Asp Val Gln Ser Ser Glu Val Pro Gly Ala Ala Ala Glu 
            20                  25                  30          


Gly Ser Gly Gly Ser Gly Val Gly Ile Gly Asp Arg Phe Lys Ile Glu 
        35                  40                  45              


Gly Arg Ala Val Val Pro Gly Val Lys Pro Gln Asp Trp Ile Ser Ala 
    50                  55                  60                  


Ala Arg Val Leu Val Asp Gly Glu Glu His Val Gly Phe Leu Lys Thr 
65                  70                  75                  80  


Asp Gly Ser Phe Val Val His Asp Ile Pro Ser Gly Ser Tyr Val Val 
                85                  90                  95      


Glu Val Val Ser Pro Ala Tyr Arg Phe Asp Pro Val Arg Val Asp Ile 
            100                 105                 110         


Thr Ser Lys Gly Lys Met Arg Ala Arg Tyr Val Asn Tyr Ile Lys Thr 
        115                 120                 125             


Ser Glu Val Val Arg Leu Pro Tyr Pro Leu Gln Met Lys Ser Ser Gly 
    130                 135                 140                 


Pro Pro Ser Tyr Phe Ile Lys Arg Glu Ser Trp Gly Trp Thr Asp Phe 
145                 150                 155                 160 


Leu Met Asn Pro Met Val Met Met Met Val Leu Pro Leu Leu Ile Phe 
                165                 170                 175     


Val Leu Leu Pro Lys Val Val Asn Thr Ser Asp Pro Asp Met Arg Arg 
            180                 185                 190         


Glu Met Glu Gln Ser Met Asn Met Leu Asn Ser Asn His Glu Leu Pro 
        195                 200                 205             


Asp Val Ser Glu Phe Met Thr Arg Leu Phe Ser Ser Lys Ser Ser Gly 
    210                 215                 220                 


Lys Ser Ser Ser Gly Ser Ser Lys Thr Gly Lys Ser Gly Ala Gly Lys 
225                 230                 235                 240 


Arg Arg 
        


<210>  4605
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  4605

Met Glu Ser Asn Leu Ser Gly Leu Val Pro Ala Ala Gly Leu Val Pro 
1               5                   10                  15      


Ala Leu Pro Pro Ala Val Thr Leu Gly Leu Thr Ala Ala Tyr Thr Thr 
            20                  25                  30          


Leu Tyr Ala Leu Leu Phe Phe Ser Val Tyr Ala Gln Leu Trp Leu Val 
        35                  40                  45              


Leu Leu Tyr Gly His Lys Arg Leu Ser Tyr Gln Thr Val Phe Leu Ala 
    50                  55                  60                  


Leu Cys Leu Leu Trp Ala Ala Leu Arg Thr Thr Leu Phe Ser Phe Tyr 
65                  70                  75                  80  


Phe Arg Asp Thr Pro Arg Ala Asn Arg Leu Gly Pro Leu Pro Phe Trp 
                85                  90                  95      


Leu Leu Tyr Cys Cys Pro Val Cys Leu Gln Phe Phe Thr Leu Thr Leu 
            100                 105                 110         


Met Asn Leu Tyr Phe Ala Gln Val Val Phe Lys Ala Lys Val Lys Arg 
        115                 120                 125             


Arg Pro Glu Met Ser Arg Gly Leu Leu Ala Val Arg Gly Ala Phe Val 
    130                 135                 140                 


Gly Ala Ser Leu Leu Phe Leu Leu Val Asn Val Leu Cys Ala Val Leu 
145                 150                 155                 160 


Ser His Arg Arg Arg Ala Gln Pro Trp Ala Leu Leu Leu Val Arg Val 
                165                 170                 175     


Leu Val Ser Asp Ser Leu Phe Val Ile Cys Ala Leu Ser Leu Ala Ala 
            180                 185                 190         


Cys Leu Cys Leu Val Ala Arg Arg Ala Pro Ser Thr Ser Ile Tyr Leu 
        195                 200                 205             


Glu Ala Lys Gly Thr Ser Val Cys Gln Ala Ala Ala Met Gly Gly Ala 
    210                 215                 220                 


Met Val Leu Leu Tyr Ala Ser Arg Ala Cys Tyr Asn Leu Thr Ala Leu 
225                 230                 235                 240 


Ala Leu Ala Pro Gln Ser Arg Leu Asp Thr Phe Asp Tyr Asp Trp Tyr 
                245                 250                 255     


Asn Val Ser Asp Gln Ala Asp Leu Val Asn Asp Leu Gly Asn Lys Gly 
            260                 265                 270         


Tyr Leu Val Phe Gly Leu Ile Leu Phe Val Trp Glu Leu Leu Pro Thr 
        275                 280                 285             


Thr Leu Leu Val Gly Phe Phe Arg Val His Arg Pro Pro Gln Asp Leu 
    290                 295                 300                 


Ser Thr Ser His Ile Leu Asn Gly Gln Val Phe Ala Ser Arg Ser Tyr 
305                 310                 315                 320 


Phe Phe Asp Arg Ala Gly His Cys Glu Asp Glu Gly Cys Ser Trp Glu 
                325                 330                 335     


His Ser Arg Gly Glu Ser Thr Arg Cys Gln Asp Gln Ala Ala Thr Thr 
            340                 345                 350         


Thr Val Ser Thr Pro Pro His Arg Arg Asp Pro Pro Pro Ser Pro Thr 
        355                 360                 365             


Glu Tyr Pro Gly Pro Ser Pro Pro His Pro Arg Pro Leu Cys Gln Val 
    370                 375                 380                 


Cys Leu Pro Leu Leu Ala Gln Asp Pro Gly Gly Arg Gly Tyr Pro Leu 
385                 390                 395                 400 


Leu Trp Pro Ala Pro Cys Cys Ser Cys His Ser Glu Leu Val Pro Ser 
                405                 410                 415     


Pro 
    


<210>  4606
<211>  363
<212>  PRT
<213>  Homo sapiens

<400>  4606

Met Ala Ser Lys Ser Trp Leu Asn Phe Leu Thr Phe Leu Cys Gly Ser 
1               5                   10                  15      


Ala Ile Gly Phe Leu Leu Cys Ser Gln Leu Phe Ser Ile Leu Leu Gly 
            20                  25                  30          


Glu Lys Val Asp Thr Gln Pro Asn Val Leu His Asn Asp Pro His Ala 
        35                  40                  45              


Arg His Ser Asp Asp Asn Gly Gln Asn His Leu Glu Gly Gln Met Asn 
    50                  55                  60                  


Phe Asn Ala Asp Ser Ser Gln His Lys Asp Glu Asn Thr Asp Ile Ala 
65                  70                  75                  80  


Glu Asn Leu Tyr Gln Lys Val Arg Ile Leu Cys Trp Val Met Thr Gly 
                85                  90                  95      


Pro Gln Asn Leu Glu Lys Lys Ala Lys His Val Lys Ala Thr Trp Ala 
            100                 105                 110         


Gln Arg Cys Asn Lys Val Leu Phe Met Ser Ser Glu Glu Asn Lys Asp 
        115                 120                 125             


Phe Pro Ala Val Gly Leu Lys Thr Lys Glu Gly Arg Asp Gln Leu Tyr 
    130                 135                 140                 


Trp Lys Thr Ile Lys Ala Phe Gln Tyr Val His Glu His Tyr Leu Glu 
145                 150                 155                 160 


Asp Ala Asp Trp Phe Leu Lys Ala Asp Asp Asp Thr Tyr Val Ile Leu 
                165                 170                 175     


Asp Asn Leu Arg Trp Leu Leu Ser Lys Tyr Asp Pro Glu Glu Pro Ile 
            180                 185                 190         


Tyr Phe Gly Arg Arg Phe Lys Pro Tyr Val Lys Gln Gly Tyr Met Ser 
        195                 200                 205             


Gly Gly Ala Gly Tyr Val Leu Ser Lys Glu Ala Leu Lys Arg Phe Val 
    210                 215                 220                 


Asp Ala Phe Lys Thr Asp Lys Cys Thr His Ser Ser Ser Ile Glu Asp 
225                 230                 235                 240 


Leu Ala Leu Gly Arg Cys Met Glu Ile Met Asn Val Glu Ala Gly Asp 
                245                 250                 255     


Ser Arg Asp Thr Ile Gly Lys Glu Thr Phe His Pro Phe Val Pro Glu 
            260                 265                 270         


His His Leu Ile Lys Gly Tyr Leu Pro Arg Thr Phe Trp Tyr Trp Asn 
        275                 280                 285             


Tyr Asn Tyr Tyr Pro Pro Val Glu Gly Pro Gly Cys Cys Ser Asp Leu 
    290                 295                 300                 


Ala Val Ser Phe His Tyr Val Asp Ser Thr Thr Met Tyr Glu Leu Glu 
305                 310                 315                 320 


Tyr Leu Val Tyr His Leu Arg Pro Tyr Gly Tyr Leu Tyr Arg Tyr Gln 
                325                 330                 335     


Pro Thr Leu Pro Glu Arg Ile Leu Lys Glu Ile Ser Gln Ala Asn Lys 
            340                 345                 350         


Asn Glu Asp Thr Lys Val Lys Leu Gly Asn Pro 
        355                 360             


<210>  4607
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  4607

Met Ala Arg Ile Leu Leu Leu Phe Leu Pro Gly Leu Val Ala Val Cys 
1               5                   10                  15      


Ala Val His Gly Ile Phe Met Asp Arg Leu Ala Ser Lys Lys Leu Cys 
            20                  25                  30          


Ala Asp Asp Glu Cys Val Tyr Thr Ile Ser Leu Ala Ser Ala Gln Glu 
        35                  40                  45              


Asp Tyr Asn Ala Pro Asp Cys Arg Phe Ile Asn Val Lys Lys Gly Gln 
    50                  55                  60                  


Gln Ile Tyr Val Tyr Ser Lys Leu Val Lys Glu Asn Gly Ala Gly Glu 
65                  70                  75                  80  


Phe Trp Ala Gly Ser Val Tyr Gly Asp Gly Gln Asp Glu Met Gly Val 
                85                  90                  95      


Val Gly Tyr Phe Pro Arg Asn Leu Val Lys Glu Gln Arg Val Tyr Gln 
            100                 105                 110         


Glu Ala Thr Lys Glu Val Pro Thr Thr Asp Ile Asp Phe Phe Cys Glu 
        115                 120                 125             


<210>  4608
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  4608

Met Glu Asp Tyr Ala Leu Thr Phe Gly Ile Asn Pro Phe Ile Ala Leu 
1               5                   10                  15      


Met Ile Gln Pro Ile Val Thr Met Thr Val Val Asp Asn Gln Gly Leu 
            20                  25                  30          


Gly Leu Pro Val Asp Ile Gln His Lys Ala Lys Pro Ser Pro Lys Ala 
        35                  40                  45              


Ser Gln Met Leu Pro Pro Asp Leu Gly Pro Pro Ser Phe Gln Asn Leu 
    50                  55                  60                  


Leu Ser Pro Ser Glu Lys Leu Glu Pro Trp Asp Pro Gly Met Arg Lys 
65                  70                  75                  80  


Leu Thr Val Gln Thr Cys Gly Leu Thr Phe Ile His Pro Ala Gly His 
                85                  90                  95      


Gly Leu Cys His Pro Thr Ala Glu Ala Ser Ala Glu Thr Leu Ser Ser 
            100                 105                 110         


Thr Ala Leu Asn Arg Pro Ser Val Arg Glu Gly Ala Cys Asn Glu Lys 
        115                 120                 125             


Ser Thr Glu Asn Lys Lys Pro Gln Asp Ser Val Leu Trp Ser His Ser 
    130                 135                 140                 


Arg Trp Phe Gln Gly Asn 
145                 150 


<210>  4609
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  4609

Met Ala Glu Asp Lys Glu Thr Lys His Gly Gly His Lys Asn Gly Arg 
1               5                   10                  15      


Lys Gly Gly Leu Ser Gly Thr Ser Phe Phe Thr Trp Phe Met Val Ile 
            20                  25                  30          


Ala Leu Leu Gly Val Trp Thr Ser Val Ala Val Val Trp Phe Asp Leu 
        35                  40                  45              


Val Asp Tyr Glu Glu Val Leu Ala Lys Ala Lys Asp Phe Arg Tyr Asn 
    50                  55                  60                  


Leu Ser Glu Val Leu Gln Gly Lys Leu Gly Ile Tyr Asp Ala Asp Gly 
65                  70                  75                  80  


Asp Gly Asp Phe Asp Val Asp Asp Ala Lys Val Leu Leu Glu Gly Pro 
                85                  90                  95      


Ser Gly Val Ala Lys Arg Lys Thr Lys Ala Lys Val Lys Glu Leu Thr 
            100                 105                 110         


Lys Glu Glu Leu Lys Lys Glu Lys Glu Lys Pro Glu Ser Arg Lys Glu 
        115                 120                 125             


Ser Lys Asn Glu Glu Arg Lys Lys Gly Lys Lys Glu Asp Val Arg Lys 
    130                 135                 140                 


Asp Lys Lys Ile Ala Asp Ala Asp Leu Ser Arg Lys Glu Ser Pro Lys 
145                 150                 155                 160 


Gly Lys Lys Asp Arg Glu Lys Glu Lys Val Asp Leu Glu Lys Ser Ala 
                165                 170                 175     


Lys Thr Lys Glu Asn Arg Lys Lys Ser Thr Asn Met Lys Asp Val Ser 
            180                 185                 190         


Ser Lys Met Ala Ser Arg Asp Lys Asp Asp Arg Lys Glu Ser Arg Ser 
        195                 200                 205             


Ser Thr Arg Tyr Ala His Leu Thr Lys Gly Asn Thr Gln Lys Arg Asn 
    210                 215                 220                 


Gly 
225 


<210>  4610
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  4610

Met Ala Val Ser Glu Arg Arg Gly Leu Gly Arg Gly Ser Pro Ala Glu 
1               5                   10                  15      


Trp Gly Gln Arg Leu Leu Leu Val Leu Leu Leu Gly Gly Cys Ser Gly 
            20                  25                  30          


Arg Ile His Gln Leu Ala Leu Thr Gly Glu Lys Arg Ala Asp Ile Gln 
        35                  40                  45              


Leu Asn Ser Phe Gly Phe Tyr Thr Asn Gly Ser Leu Glu Val Glu Leu 
    50                  55                  60                  


Ser Val Leu Arg Leu Gly Leu Arg Glu Ala Glu Glu Lys Ser Leu Leu 
65                  70                  75                  80  


Val Gly Phe Ser Leu Ser Arg Val Arg Ser Gly Arg Val Arg Ser Tyr 
                85                  90                  95      


Ser Thr Arg Asp Phe Gln Asp Cys Pro Leu Gln Lys Asn Ser Ser Ser 
            100                 105                 110         


Phe Leu Val Leu Phe Leu Ile Asn Thr Lys Asp Leu Gln Val Gln Val 
        115                 120                 125             


Arg Lys Tyr Gly Glu Gln Lys Thr Leu Phe Ile Phe Pro Gly Leu Leu 
    130                 135                 140                 


Pro Glu Ala Pro Ser Lys Pro Gly Leu Pro Lys Pro Gln Ala Thr Val 
145                 150                 155                 160 


Pro Arg Lys Val Asp Gly Gly Gly Thr Ser Ala Ala Ser Lys Pro Lys 
                165                 170                 175     


Ser Thr Pro Ala Val Ile Gln Gly Pro Ser Gly Lys Asp Lys Asp Leu 
            180                 185                 190         


Val Leu Gly Leu Ser His Leu Asn Asn Ser Tyr Asn Phe Ser Phe His 
        195                 200                 205             


Val Val Ile Gly Ser Gln Ala Glu Glu Gly Gln Tyr Ser Leu Asn Phe 
    210                 215                 220                 


His Asn Cys Asn Asn Ser Val Pro Gly Lys Glu His Pro Phe Asp Ile 
225                 230                 235                 240 


Thr Val Met Ile Arg Glu Lys Asn Pro Asp Gly Phe Leu Ser Ala Ala 
                245                 250                 255     


Glu Met Pro Leu Phe Lys Leu Tyr Met Val Met Ser Ala Cys Phe Leu 
            260                 265                 270         


Ala Ala Gly Ile Phe Trp Val Ser Ile Leu Cys Arg Asn Thr Tyr Ser 
        275                 280                 285             


Val Phe Lys Ile His Trp Leu Met Ala Ala Leu Ala Phe Thr Lys Ser 
    290                 295                 300                 


Ile Ser Leu Leu Phe His Ser Ile Asn Tyr Tyr Phe Ile Asn Ser Gln 
305                 310                 315                 320 


Gly His Pro Ile Glu Gly Leu Ala Val Met Tyr Tyr Ile Ala His Leu 
                325                 330                 335     


Leu Lys Gly Ala Leu Leu Phe Ile Thr Ile Ala Leu Ile Gly Ser Gly 
            340                 345                 350         


Trp Ala Phe Ile Lys Tyr Val Leu Ser Asp Lys Glu Lys Lys Val Phe 
        355                 360                 365             


Gly Ile Val Ile Pro Met Gln Val Leu Ala Asn Val Ala Tyr Ile Ile 
    370                 375                 380                 


Ile Glu Ser Arg Glu Glu Gly Ala Ser Asp Tyr Val Leu Trp Lys Glu 
385                 390                 395                 400 


Ile Leu Phe Leu Val Asp Leu Ile Cys Cys Gly Ala Ile Leu Phe Pro 
                405                 410                 415     


Val Val Trp Ser Ile Arg His Leu Gln Asp Ala Ser Gly Thr Asp Gly 
            420                 425                 430         


Lys Val Ala Val Asn Leu Ala Lys Leu Lys Leu Phe Arg His Tyr Tyr 
        435                 440                 445             


Val Met Val Ile Cys Tyr Val Tyr Phe Thr Arg Ile Ile Ala Ile Leu 
    450                 455                 460                 


Leu Gln Val Ala Val Pro Phe Gln Trp Gln Trp Leu Tyr Gln Leu Leu 
465                 470                 475                 480 


Val Glu Gly Ser Thr Leu Ala Phe Phe Val Leu Thr Gly Tyr Lys Phe 
                485                 490                 495     


Gln Pro Thr Gly Asn Asn Pro Tyr Leu Gln Leu Pro Gln Glu Asp Glu 
            500                 505                 510         


Glu Asp Val Gln Met Glu Gln Val Met Thr Asp Ser Gly Phe Arg Glu 
        515                 520                 525             


Gly Leu Ser Lys Val Asn Lys Thr Ala Ser Gly Arg Glu Leu Leu 
    530                 535                 540             


<210>  4611
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  4611

Met Ser Gly Met Glu Lys Leu Gln Asn Ala Ser Trp Ile Tyr Gln Gln 
1               5                   10                  15      


Lys Leu Glu Asp Pro Phe Gln Lys His Leu Asn Ser Thr Glu Glu Tyr 
            20                  25                  30          


Leu Ala Phe Leu Cys Gly Pro Arg Arg Ser His Phe Phe Leu Pro Val 
        35                  40                  45              


Ser Val Val Tyr Val Pro Ile Phe Val Val Gly Val Ile Gly Asn Val 
    50                  55                  60                  


Leu Val Cys Leu Val Ile Leu Gln His Gln Ala Met Lys Thr Pro Thr 
65                  70                  75                  80  


Asn Tyr Tyr Leu Phe Ser Leu Ala Val Ser Asp Leu Leu Val Leu Leu 
                85                  90                  95      


Leu Gly Met Pro Leu Glu Val Tyr Glu Met Trp Arg Asn Tyr Pro Phe 
            100                 105                 110         


Leu Phe Gly Pro Val Gly Cys Tyr Phe Lys Thr Ala Leu Phe Glu Thr 
        115                 120                 125             


Val Cys Phe Ala Ser Ile Leu Ser Ile Thr Thr Val Ser Val Glu Arg 
    130                 135                 140                 


Tyr Val Ala Ile Leu His Pro Phe Arg Ala Lys Leu Gln Ser Thr Arg 
145                 150                 155                 160 


Arg Arg Ala Leu Arg Ile Leu Gly Ile Val Trp Gly Phe Ser Val Leu 
                165                 170                 175     


Phe Ser Leu Pro Asn Thr Ser Ile His Gly Ile Lys Phe His Tyr Phe 
            180                 185                 190         


Pro Asn Gly Ser Leu Val Pro Gly Ser Ala Thr Cys Thr Val Ile Lys 
        195                 200                 205             


Pro Met Trp Ile Tyr Asn Phe Ile Ile Gln Val Thr Ser Phe Leu Phe 
    210                 215                 220                 


Tyr Leu Leu Pro Met Thr Val Ile Ser Val Leu Tyr Tyr Leu Met Ala 
225                 230                 235                 240 


Leu Arg Leu Lys Lys Asp Lys Ser Leu Glu Ala Asp Glu Gly Asn Ala 
                245                 250                 255     


Asn Ile Gln Arg Pro Cys Arg Lys Ser Val Asn Lys Met Leu Phe Val 
            260                 265                 270         


Leu Val Leu Val Phe Ala Ile Cys Trp Ala Pro Phe His Ile Asp Arg 
        275                 280                 285             


Leu Phe Phe Ser Phe Val Glu Glu Trp Ser Glu Ser Leu Ala Ala Val 
    290                 295                 300                 


Phe Asn Leu Val His Val Val Ser Gly Val Phe Phe Tyr Leu Ser Ser 
305                 310                 315                 320 


Ala Val Asn Pro Ile Ile Tyr Asn Leu Leu Ser Arg Arg Phe Gln Ala 
                325                 330                 335     


Ala Phe Gln Asn Val Ile Ser Ser Phe His Lys Gln Trp His Ser Gln 
            340                 345                 350         


His Asp Pro Gln Leu Pro Pro Ala Gln Arg Asn Ile Phe Leu Thr Glu 
        355                 360                 365             


Cys His Phe Val Glu Leu Thr Glu Asp Ile Gly Pro Gln Phe Pro Cys 
    370                 375                 380                 


Gln Ser Ser Met His Asn Ser His Leu Pro Ala Ala Leu Ser Ser Glu 
385                 390                 395                 400 


Gln Met Ser Arg Thr Asn Tyr Gln Ser Phe His Phe Asn Lys Thr 
                405                 410                 415 


<210>  4612
<211>  486
<212>  PRT
<213>  Homo sapiens

<400>  4612

Met Tyr Ile Lys Met Ala Thr Leu Ala Asn Gly Gln Ala Asp Asn Ala 
1               5                   10                  15      


Ser Leu Ser Thr Asn Gly Leu Gly Ser Ser Pro Gly Ser Ala Gly His 
            20                  25                  30          


Met Asn Gly Leu Ser His Ser Pro Gly Asn Pro Ser Thr Ile Pro Met 
        35                  40                  45              


Lys Asp His Asp Ala Ile Lys Leu Phe Ile Gly Gln Ile Pro Arg Asn 
    50                  55                  60                  


Leu Asp Glu Lys Asp Leu Lys Pro Leu Phe Glu Glu Phe Gly Lys Ile 
65                  70                  75                  80  


Tyr Glu Leu Thr Val Leu Lys Asp Arg Phe Thr Gly Met His Lys Gly 
                85                  90                  95      


Cys Ala Phe Leu Thr Tyr Cys Glu Arg Glu Ser Ala Leu Lys Ala Gln 
            100                 105                 110         


Ser Ala Leu His Glu Gln Lys Thr Leu Pro Gly Met Asn Arg Pro Ile 
        115                 120                 125             


Gln Val Lys Pro Ala Asp Ser Glu Ser Arg Gly Gly Ser Ser Cys Leu 
    130                 135                 140                 


Arg Gln Pro Pro Ser Gln Asp Arg Lys Leu Phe Val Gly Met Leu Asn 
145                 150                 155                 160 


Lys Gln Gln Ser Glu Asp Asp Val Arg Arg Leu Phe Glu Ala Phe Gly 
                165                 170                 175     


Asn Ile Glu Glu Cys Thr Ile Leu Arg Gly Pro Asp Gly Asn Ser Lys 
            180                 185                 190         


Gly Cys Ala Phe Val Lys Tyr Ser Ser His Ala Glu Ala Gln Ala Ala 
        195                 200                 205             


Ile Asn Ala Leu His Gly Ser Gln Thr Met Pro Gly Ala Ser Ser Ser 
    210                 215                 220                 


Leu Val Val Lys Phe Ala Asp Thr Asp Lys Glu Arg Thr Met Arg Arg 
225                 230                 235                 240 


Met Gln Gln Met Ala Gly Gln Met Gly Met Phe Asn Pro Met Ala Ile 
                245                 250                 255     


Pro Phe Gly Ala Tyr Gly Ala Tyr Ala Gln Ala Leu Met Gln Gln Gln 
            260                 265                 270         


Ala Ala Leu Met Ala Ser Val Ala Gln Gly Gly Tyr Leu Asn Pro Met 
        275                 280                 285             


Ala Ala Phe Ala Ala Ala Gln Met Gln Gln Met Ala Ala Leu Asn Met 
    290                 295                 300                 


Asn Gly Leu Ala Ala Ala Pro Met Thr Pro Thr Ser Gly Gly Ser Thr 
305                 310                 315                 320 


Pro Pro Gly Ile Thr Ala Pro Ala Val Pro Ser Ile Pro Ser Pro Ile 
                325                 330                 335     


Gly Val Asn Gly Phe Thr Gly Leu Pro Pro Gln Ala Asn Gly Gln Pro 
            340                 345                 350         


Ala Ala Glu Ala Val Phe Ala Asn Gly Ile His Pro Tyr Pro Ala Gln 
        355                 360                 365             


Ser Pro Thr Ala Ala Asp Pro Leu Gln Gln Ala Tyr Ala Gly Val Gln 
    370                 375                 380                 


Gln Tyr Ala Gly Pro Ala Ala Tyr Pro Ala Ala Tyr Gly Gln Ile Ser 
385                 390                 395                 400 


Gln Ala Phe Pro Gln Pro Pro Pro Met Ile Pro Gln Gln Gln Arg Glu 
                405                 410                 415     


Gly Pro Glu Gly Cys Asn Leu Phe Ile Tyr His Leu Pro Gln Glu Phe 
            420                 425                 430         


Gly Asp Ala Glu Leu Met Gln Met Phe Leu Pro Phe Gly Phe Val Ser 
        435                 440                 445             


Phe Asp Asn Pro Ala Ser Ala Gln Thr Ala Ile Gln Ala Met Asn Gly 
    450                 455                 460                 


Phe Gln Ile Gly Met Lys Arg Leu Lys Val Gln Leu Lys Arg Pro Lys 
465                 470                 475                 480 


Asp Ala Asn Arg Pro Tyr 
                485     


<210>  4613
<211>  287
<212>  PRT
<213>  Homo sapiens

<400>  4613

Met His Arg Leu Met Gly Val Asn Ser Thr Ala Ala Ala Ala Ala Gly 
1               5                   10                  15      


Gln Pro Asn Val Ser Cys Thr Cys Asn Cys Lys Arg Ser Leu Phe Gln 
            20                  25                  30          


Ser Met Glu Ile Thr Glu Leu Glu Phe Val Gln Ile Ile Ile Ile Val 
        35                  40                  45              


Val Val Met Met Val Met Val Val Val Ile Thr Cys Leu Leu Ser His 
    50                  55                  60                  


Tyr Lys Leu Ser Ala Arg Ser Phe Ile Ser Arg His Ser Gln Gly Arg 
65                  70                  75                  80  


Arg Arg Glu Asp Ala Leu Ser Ser Glu Gly Cys Leu Trp Pro Ser Glu 
                85                  90                  95      


Ser Thr Val Ser Gly Asn Gly Ile Pro Glu Pro Gln Val Tyr Ala Pro 
            100                 105                 110         


Pro Arg Pro Thr Asp Arg Leu Ala Val Pro Pro Phe Ala Gln Arg Glu 
        115                 120                 125             


Arg Phe His Arg Phe Gln Pro Thr Tyr Pro Tyr Leu Gln His Glu Ile 
    130                 135                 140                 


Asp Leu Pro Pro Thr Ile Ser Leu Ser Asp Gly Glu Glu Pro Pro Pro 
145                 150                 155                 160 


Tyr Gln Gly Pro Cys Thr Leu Gln Leu Arg Asp Pro Glu Gln Gln Leu 
                165                 170                 175     


Glu Leu Asn Arg Glu Ser Val Arg Ala Pro Pro Asn Arg Thr Ile Phe 
            180                 185                 190         


Asp Ser Asp Leu Met Asp Ser Ala Arg Leu Gly Gly Pro Cys Pro Pro 
        195                 200                 205             


Ser Ser Asn Ser Gly Ile Ser Ala Thr Cys Tyr Gly Ser Gly Gly Arg 
    210                 215                 220                 


Met Glu Gly Pro Pro Pro Thr Tyr Ser Glu Val Ile Gly His Tyr Pro 
225                 230                 235                 240 


Gly Ser Ser Phe Gln His Gln Gln Ser Ser Gly Pro Pro Ser Leu Leu 
                245                 250                 255     


Glu Gly Thr Arg Leu His His Thr His Ile Ala Pro Leu Glu Ser Ala 
            260                 265                 270         


Ala Ile Trp Ser Lys Glu Lys Asp Lys Gln Lys Gly His Pro Leu 
        275                 280                 285         


<210>  4614
<211>  775
<212>  PRT
<213>  Homo sapiens

<400>  4614

Met Ala Pro Val Gly Gly Gly Gly Arg Pro Val Gly Gly Pro Ala Arg 
1               5                   10                  15      


Gly Arg Leu Leu Leu Ala Ala Pro Val Leu Leu Val Leu Leu Trp Ala 
            20                  25                  30          


Leu Gly Ala Arg Gly Gln Gly Ser Pro Gln Gln Gly Thr Ile Val Gly 
        35                  40                  45              


Met Arg Leu Ala Ser Cys Asn Lys Ser Cys Gly Thr Asn Pro Asp Gly 
    50                  55                  60                  


Ile Ile Phe Val Ser Glu Gly Ser Thr Val Asn Leu Arg Leu Tyr Gly 
65                  70                  75                  80  


Tyr Ser Leu Gly Asn Ile Ser Ser Asn Leu Ile Ser Phe Thr Glu Val 
                85                  90                  95      


Asp Asp Ala Glu Thr Leu His Lys Ser Thr Ser Cys Leu Glu Leu Thr 
            100                 105                 110         


Lys Asp Leu Val Val Gln Gln Leu Val Asn Val Ser Arg Gly Asn Thr 
        115                 120                 125             


Ser Gly Val Leu Val Val Leu Thr Lys Phe Leu Arg Arg Ser Glu Ser 
    130                 135                 140                 


Met Lys Leu Tyr Ala Leu Cys Thr Arg Ala Gln Pro Asp Gly Pro Trp 
145                 150                 155                 160 


Leu Lys Trp Thr Asp Lys Asp Ser Leu Leu Phe Met Val Glu Glu Pro 
                165                 170                 175     


Gly Arg Phe Leu Pro Leu Trp Leu His Ile Leu Leu Ile Thr Val Leu 
            180                 185                 190         


Leu Val Leu Ser Gly Ile Phe Ser Gly Leu Asn Leu Gly Leu Met Ala 
        195                 200                 205             


Leu Asp Pro Met Glu Leu Arg Ile Val Gln Asn Cys Gly Thr Glu Lys 
    210                 215                 220                 


Glu Arg Arg Tyr Ala Arg Lys Ile Glu Pro Ile Arg Arg Lys Gly Asn 
225                 230                 235                 240 


Tyr Leu Leu Cys Ser Leu Leu Leu Gly Asn Val Leu Val Asn Thr Ser 
                245                 250                 255     


Leu Thr Ile Leu Leu Asp Asn Leu Ile Gly Ser Gly Leu Met Ala Val 
            260                 265                 270         


Ala Ser Ser Thr Ile Gly Ile Val Ile Phe Gly Glu Ile Leu Pro Gln 
        275                 280                 285             


Ala Leu Cys Ser Arg His Gly Leu Ala Val Gly Ala Asn Thr Ile Leu 
    290                 295                 300                 


Leu Thr Lys Phe Phe Met Leu Leu Thr Phe Pro Leu Ser Phe Pro Ile 
305                 310                 315                 320 


Ser Lys Leu Leu Asp Phe Phe Leu Gly Gln Glu Ile Arg Thr Val Tyr 
                325                 330                 335     


Asn Arg Glu Lys Leu Met Glu Met Leu Lys Val Thr Glu Pro Tyr Asn 
            340                 345                 350         


Asp Leu Val Lys Glu Glu Leu Asn Met Ile Gln Gly Ala Leu Glu Leu 
        355                 360                 365             


Arg Thr Lys Thr Val Glu Asp Ile Met Thr Gln Leu Gln Asp Cys Phe 
    370                 375                 380                 


Met Ile Arg Ser Asp Ala Ile Leu Asp Phe Asn Thr Met Ser Glu Ile 
385                 390                 395                 400 


Met Glu Ser Gly Tyr Thr Arg Ile Pro Val Phe Glu Asp Glu Gln Ser 
                405                 410                 415     


Asn Ile Val Asp Ile Leu Tyr Val Lys Asp Leu Ala Phe Val Asp Pro 
            420                 425                 430         


Asp Asp Cys Thr Pro Leu Lys Thr Ile Thr Arg Phe Tyr Asn His Pro 
        435                 440                 445             


Val His Phe Val Phe His Asp Thr Lys Leu Asp Ala Met Leu Glu Glu 
    450                 455                 460                 


Phe Lys Lys Gly Lys Ser His Leu Ala Ile Val Gln Lys Val Asn Asn 
465                 470                 475                 480 


Glu Gly Glu Gly Asp Pro Phe Tyr Glu Val Leu Gly Leu Val Thr Leu 
                485                 490                 495     


Glu Asp Val Ile Glu Glu Ile Ile Lys Ser Glu Ile Leu Asp Glu Ser 
            500                 505                 510         


Asp Met Tyr Thr Asp Asn Arg Ser Arg Lys Arg Val Ser Glu Lys Asn 
        515                 520                 525             


Lys Arg Asp Phe Ser Ala Phe Lys Asp Ala Asp Asn Glu Leu Lys Val 
    530                 535                 540                 


Lys Ile Ser Pro Gln Leu Leu Leu Ala Ala His Arg Phe Leu Ala Thr 
545                 550                 555                 560 


Glu Val Ser Gln Phe Ser Pro Ser Leu Ile Ser Glu Lys Ile Leu Leu 
                565                 570                 575     


Arg Leu Leu Lys Tyr Pro Asp Val Ile Gln Glu Leu Lys Phe Asp Glu 
            580                 585                 590         


His Asn Lys Tyr Tyr Ala Arg His Tyr Leu Tyr Thr Arg Asn Lys Pro 
        595                 600                 605             


Ala Asp Tyr Phe Ile Leu Ile Leu Gln Gly Lys Val Glu Val Glu Ala 
    610                 615                 620                 


Gly Lys Glu Asn Met Lys Phe Glu Thr Gly Ala Phe Ser Tyr Tyr Gly 
625                 630                 635                 640 


Thr Met Ala Leu Thr Ser Val Pro Ser Asp Arg Ser Pro Ala His Pro 
                645                 650                 655     


Thr Pro Leu Ser Arg Ser Ala Ser Leu Ser Tyr Pro Asp Arg Thr Asp 
            660                 665                 670         


Val Ser Thr Ala Ala Thr Leu Ala Gly Ser Ser Asn Gln Phe Gly Ser 
        675                 680                 685             


Ser Val Leu Gly Gln Tyr Ile Ser Asp Phe Ser Val Arg Ala Leu Val 
    690                 695                 700                 


Asp Leu Gln Tyr Ile Lys Ile Thr Arg Gln Gln Tyr Gln Asn Gly Leu 
705                 710                 715                 720 


Leu Ala Ser Arg Met Glu Asn Ser Pro Gln Phe Pro Ile Asp Gly Cys 
                725                 730                 735     


Thr Thr His Met Glu Asn Leu Ala Glu Lys Ser Glu Leu Pro Val Val 
            740                 745                 750         


Asp Glu Thr Thr Thr Leu Leu Asn Glu Arg Asn Ser Leu Leu His Lys 
        755                 760                 765             


Ala Ser His Glu Asn Ala Ile 
    770                 775 


<210>  4615
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  4615

Met Ser Lys Gly Thr Ser Ser Asp Thr Ser Leu Gly Arg Val Ser Arg 
1               5                   10                  15      


Ala Ala Phe Pro Ser Pro Thr Ala Ala Glu Met Ala Glu Ile Ser Arg 
            20                  25                  30          


Ile Gln Tyr Glu Met Glu Tyr Thr Glu Gly Ile Ser Gln Arg Met Arg 
        35                  40                  45              


Val Pro Glu Lys Leu Lys Val Ala Pro Pro Asn Ala Asp Leu Glu Gln 
    50                  55                  60                  


Gly Phe Gln Glu Gly Val Pro Asn Ala Ser Val Ile Met Gln Val Pro 
65                  70                  75                  80  


Glu Arg Ile Val Val Ala Gly Asn Asn Glu Asp Val Ser Phe Ser Arg 
                85                  90                  95      


Pro Ala Asp Leu Asp Leu Ile Gln Ser Thr Pro Phe Lys Pro Leu Ala 
            100                 105                 110         


Leu Lys Thr Pro Pro Arg Val Leu Thr Leu Ser Glu Arg Pro Leu Asp 
        115                 120                 125             


Phe Leu Asp Leu Glu Arg Pro Pro Thr Thr Pro Gln Asn Glu Glu Ile 
    130                 135                 140                 


Arg Ala Val Gly Arg Leu Lys Arg Glu Arg Ser Met Ser Glu Asn Ala 
145                 150                 155                 160 


Val Arg Gln Asn Gly Gln Leu Val Arg Asn Asp Ser Leu Trp His Arg 
                165                 170                 175     


Ser Asp Ser Ala Pro Arg Asn Lys Ile Ser Arg Phe Gln Ala Pro Ile 
            180                 185                 190         


Ser Ala Pro Glu Tyr Thr Val Thr Pro Ser Pro Gln Gln Ala Arg Val 
        195                 200                 205             


Cys Pro Pro His Met Leu Pro Glu Asp Gly Ala Asn Leu Ser Ser Ala 
    210                 215                 220                 


Arg Gly Ile Leu Ser Leu Ile Gln Ser Ser Thr Arg Arg Ala Tyr Gln 
225                 230                 235                 240 


Gln Ile Leu Asp Val Leu Asp Glu Asn Arg Arg Pro Val Leu Arg Gly 
                245                 250                 255     


Gly Ser Ala Ala Ala Thr Ser Asn Pro His His Asp Asn Val Arg Tyr 
            260                 265                 270         


Gly Ile Ser Asn Ile Asp Thr Thr Ile Glu Gly Thr Ser Asp Asp Leu 
        275                 280                 285             


Thr Val Val Asp Ala Ala Ser Leu Arg Arg Gln Ile Ile Lys Leu Asn 
    290                 295                 300                 


Arg Arg Leu Gln Leu Leu Glu Glu Glu Asn Lys Glu Arg Ala Lys Arg 
305                 310                 315                 320 


Glu Met Val Met Tyr Ser Ile Thr Val Ala Phe Trp Leu Leu Asn Ser 
                325                 330                 335     


Trp Leu Trp Phe Arg Arg 
            340         


<210>  4616
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  4616

Met Ala Ala Ala Val Pro Lys Arg Met Arg Gly Pro Ala Gln Ala Lys 
1               5                   10                  15      


Leu Leu Pro Gly Ser Ala Ile Gln Ala Leu Val Gly Leu Ala Arg Pro 
            20                  25                  30          


Leu Val Leu Ala Leu Leu Leu Val Ser Ala Ala Leu Ser Ser Val Val 
        35                  40                  45              


Ser Arg Thr Asp Ser Pro Ser Pro Thr Val Leu Asn Ser His Ile Ser 
    50                  55                  60                  


Thr Pro Asn Val Asn Ala Leu Thr His Glu Asn Gln Thr Lys Pro Ser 
65                  70                  75                  80  


Ile Ser Gln Ile Ser Thr Thr Leu Pro Pro Thr Thr Ser Thr Lys Lys 
                85                  90                  95      


Ser Gly Gly Ala Ser Val Val Pro His Pro Ser Pro Thr Pro Leu Ser 
            100                 105                 110         


Gln Glu Glu Ala Asp Asn Asn Glu Asp Pro Ser Ile Glu Glu Glu Asp 
        115                 120                 125             


Leu Leu Met Leu Asn Ser Ser Pro Ser Thr Ala Lys Asp Thr Leu Asp 
    130                 135                 140                 


Asn Gly Asp Tyr Gly Glu Pro Asp Tyr Asp Trp Thr Thr Gly Pro Arg 
145                 150                 155                 160 


Asp Asp Asp Glu Ser Asp Asp Thr Leu Glu Glu Asn Arg Gly Tyr Met 
                165                 170                 175     


Glu Ile Glu Gln Ser Val Lys Ser Phe Lys Met Pro Ser Ser Asn Ile 
            180                 185                 190         


Glu Glu Glu Asp Ser His Phe Phe Phe His Leu Ile Ile Phe Ala Phe 
        195                 200                 205             


Cys Ile Ala Val Val Tyr Ile Thr Tyr His Asn Lys Arg Lys Ile Phe 
    210                 215                 220                 


Leu Leu Val Gln Ser Arg Lys Trp Arg Asp Gly Leu Cys Ser Lys Thr 
225                 230                 235                 240 


Val Glu Tyr His Arg Leu Asp Gln Asn Val Asn Glu Ala Met Pro Ser 
                245                 250                 255     


Leu Lys Ile Thr Asn Asp Tyr Ile Phe 
            260                 265 


<210>  4617
<211>  592
<212>  PRT
<213>  Homo sapiens

<400>  4617

Met Glu Lys Ala Arg Pro Leu Trp Ala Asn Ser Leu Gln Phe Val Phe 
1               5                   10                  15      


Ala Cys Ile Ser Tyr Ala Val Gly Leu Gly Asn Val Trp Arg Phe Pro 
            20                  25                  30          


Tyr Leu Cys Gln Met Tyr Gly Gly Gly Ser Phe Leu Val Pro Tyr Ile 
        35                  40                  45              


Ile Met Leu Ile Val Glu Gly Met Pro Leu Leu Tyr Leu Glu Leu Ala 
    50                  55                  60                  


Val Gly Gln Arg Met Arg Gln Gly Ser Ile Gly Ala Trp Arg Thr Ile 
65                  70                  75                  80  


Ser Pro Tyr Leu Ser Gly Val Gly Val Ala Ser Val Val Val Ser Phe 
                85                  90                  95      


Phe Leu Ser Met Tyr Tyr Asn Val Ile Asn Ala Trp Ala Phe Trp Tyr 
            100                 105                 110         


Leu Phe His Ser Phe Gln Asp Pro Leu Pro Trp Ser Val Cys Pro Leu 
        115                 120                 125             


Asn Gly Asn His Thr Gly Tyr Asp Glu Glu Cys Glu Lys Ala Ser Ser 
    130                 135                 140                 


Thr Gln Tyr Phe Trp Tyr Arg Lys Thr Leu Asn Ile Ser Pro Ser Leu 
145                 150                 155                 160 


Gln Glu Asn Gly Gly Val Gln Trp Glu Pro Ala Leu Cys Leu Leu Leu 
                165                 170                 175     


Ala Trp Leu Val Val Tyr Leu Cys Ile Leu Arg Gly Thr Glu Ser Thr 
            180                 185                 190         


Gly Lys Val Val Tyr Phe Thr Ala Ser Leu Pro Tyr Cys Val Leu Ile 
        195                 200                 205             


Ile Tyr Leu Ile Arg Gly Leu Thr Leu His Gly Ala Thr Asn Gly Leu 
    210                 215                 220                 


Met Tyr Met Phe Thr Pro Lys Ile Glu Gln Leu Ala Asn Pro Lys Ala 
225                 230                 235                 240 


Trp Ile Asn Ala Ala Thr Gln Ile Phe Phe Ser Leu Gly Leu Gly Phe 
                245                 250                 255     


Gly Ser Leu Ile Ala Phe Ala Ser Tyr Asn Glu Pro Ser Asn Asn Cys 
            260                 265                 270         


Gln Lys His Ala Ile Ile Val Ser Leu Ile Asn Ser Phe Thr Ser Ile 
        275                 280                 285             


Phe Ala Ser Ile Val Thr Phe Ser Ile Tyr Gly Phe Lys Ala Thr Phe 
    290                 295                 300                 


Asn Tyr Glu Asn Cys Leu Lys Lys Val Ser Leu Leu Leu Thr Asn Thr 
305                 310                 315                 320 


Phe Asp Leu Glu Asp Gly Phe Leu Thr Ala Ser Asn Leu Glu Gln Val 
                325                 330                 335     


Lys Gly Tyr Leu Ala Ser Ala Tyr Pro Ser Lys Tyr Ser Glu Met Phe 
            340                 345                 350         


Pro Gln Ile Lys Asn Cys Ser Leu Glu Ser Glu Leu Asp Thr Ala Val 
        355                 360                 365             


Gln Gly Thr Gly Leu Ala Phe Ile Val Tyr Thr Glu Ala Ile Lys Asn 
    370                 375                 380                 


Met Glu Val Ser Gln Leu Trp Ser Val Leu Tyr Phe Phe Met Leu Leu 
385                 390                 395                 400 


Met Leu Gly Ile Gly Ser Met Leu Gly Asn Thr Ala Ala Ile Leu Thr 
                405                 410                 415     


Pro Leu Thr Asp Ser Lys Ile Ile Ser Ser His Leu Pro Lys Glu Ala 
            420                 425                 430         


Ile Ser Gly Leu Val Cys Leu Val Asn Cys Ala Ile Gly Met Val Phe 
        435                 440                 445             


Thr Met Glu Ala Gly Asn Tyr Trp Phe Asp Ile Phe Asn Asp Tyr Ala 
    450                 455                 460                 


Ala Thr Leu Ser Leu Leu Leu Ile Val Leu Val Glu Thr Ile Ala Val 
465                 470                 475                 480 


Cys Tyr Val Tyr Gly Leu Arg Arg Phe Glu Ser Asp Leu Lys Ala Met 
                485                 490                 495     


Thr Gly Arg Ala Val Ser Trp Tyr Trp Lys Val Met Trp Ala Gly Val 
            500                 505                 510         


Ser Pro Leu Leu Ile Val Ser Leu Phe Val Phe Tyr Leu Ser Asp Tyr 
        515                 520                 525             


Ile Leu Thr Gly Thr Leu Lys Tyr Gln Ala Trp Asp Ala Ser Gln Gly 
    530                 535                 540                 


Gln Leu Val Thr Lys Asp Tyr Pro Ala Tyr Ala Leu Ala Val Ile Gly 
545                 550                 555                 560 


Leu Leu Val Ala Ser Ser Thr Met Cys Ile Pro Leu Ala Ala Leu Gly 
                565                 570                 575     


Thr Phe Val Gln Arg Arg Leu Lys Arg Gly Asp Ala Asp Pro Val Ala 
            580                 585                 590         


<210>  4618
<211>  837
<212>  PRT
<213>  Homo sapiens

<400>  4618

Met Leu Arg Thr Ala Met Gly Leu Arg Ser Trp Leu Ala Ala Pro Trp 
1               5                   10                  15      


Gly Ala Leu Pro Pro Arg Pro Pro Leu Leu Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Gln Pro Pro Pro Pro Thr Trp Ala Leu Ser Pro Arg Ile 
        35                  40                  45              


Ser Leu Pro Leu Gly Ser Glu Glu Arg Pro Phe Leu Arg Phe Glu Ala 
    50                  55                  60                  


Glu His Ile Ser Asn Tyr Thr Ala Leu Leu Leu Ser Arg Asp Gly Arg 
65                  70                  75                  80  


Thr Leu Tyr Val Gly Ala Arg Glu Ala Leu Phe Ala Leu Ser Ser Asn 
                85                  90                  95      


Leu Ser Phe Leu Pro Gly Gly Glu Tyr Gln Glu Leu Leu Trp Gly Ala 
            100                 105                 110         


Asp Ala Glu Lys Lys Gln Gln Cys Ser Phe Lys Gly Lys Asp Pro Gln 
        115                 120                 125             


Arg Asp Cys Gln Asn Tyr Ile Lys Ile Leu Leu Pro Leu Ser Gly Ser 
    130                 135                 140                 


His Leu Phe Thr Cys Gly Thr Ala Ala Phe Ser Pro Met Cys Thr Tyr 
145                 150                 155                 160 


Ile Asn Met Glu Asn Phe Thr Leu Ala Arg Asp Glu Lys Gly Asn Val 
                165                 170                 175     


Leu Leu Glu Asp Gly Lys Gly Arg Cys Pro Phe Asp Pro Asn Phe Lys 
            180                 185                 190         


Ser Thr Ala Leu Val Val Asp Gly Glu Leu Tyr Thr Gly Thr Val Ser 
        195                 200                 205             


Ser Phe Gln Gly Asn Asp Pro Ala Ile Ser Arg Ser Gln Ser Leu Arg 
    210                 215                 220                 


Pro Thr Lys Thr Glu Ser Ser Leu Asn Trp Leu Gln Asp Pro Ala Phe 
225                 230                 235                 240 


Val Ala Ser Ala Tyr Ile Pro Glu Ser Leu Gly Ser Leu Gln Gly Asp 
                245                 250                 255     


Asp Asp Lys Ile Tyr Phe Phe Phe Ser Glu Thr Gly Gln Glu Phe Glu 
            260                 265                 270         


Phe Phe Glu Asn Thr Ile Val Ser Arg Ile Ala Arg Ile Cys Lys Gly 
        275                 280                 285             


Asp Glu Gly Gly Glu Arg Val Leu Gln Gln Arg Trp Thr Ser Phe Leu 
    290                 295                 300                 


Lys Ala Gln Leu Leu Cys Ser Arg Pro Asp Asp Gly Phe Pro Phe Asn 
305                 310                 315                 320 


Val Leu Gln Asp Val Phe Thr Leu Ser Pro Ser Pro Gln Asp Trp Arg 
                325                 330                 335     


Asp Thr Leu Phe Tyr Gly Val Phe Thr Ser Gln Trp His Arg Gly Thr 
            340                 345                 350         


Thr Glu Gly Ser Ala Val Cys Val Phe Thr Met Lys Asp Val Gln Arg 
        355                 360                 365             


Val Phe Ser Gly Leu Tyr Lys Glu Val Asn Arg Glu Thr Gln Gln Trp 
    370                 375                 380                 


Tyr Thr Val Thr His Pro Val Pro Thr Pro Arg Pro Gly Ala Cys Ile 
385                 390                 395                 400 


Thr Asn Ser Ala Arg Glu Arg Lys Ile Asn Ser Ser Leu Gln Leu Pro 
                405                 410                 415     


Asp Arg Val Leu Asn Phe Leu Lys Asp His Phe Leu Met Asp Gly Gln 
            420                 425                 430         


Val Arg Ser Arg Met Leu Leu Leu Gln Pro Gln Ala Arg Tyr Gln Arg 
        435                 440                 445             


Val Ala Val His Arg Val Pro Gly Leu His His Thr Tyr Asp Val Leu 
    450                 455                 460                 


Phe Leu Gly Thr Gly Asp Gly Arg Leu His Lys Ala Val Ser Val Gly 
465                 470                 475                 480 


Pro Arg Val His Ile Ile Glu Glu Leu Gln Ile Phe Ser Ser Gly Gln 
                485                 490                 495     


Pro Val Gln Asn Leu Leu Leu Asp Thr His Arg Gly Leu Leu Tyr Ala 
            500                 505                 510         


Ala Ser His Ser Gly Val Val Gln Val Pro Met Ala Asn Cys Ser Leu 
        515                 520                 525             


Tyr Arg Ser Cys Gly Asp Cys Leu Leu Ala Arg Asp Pro Tyr Cys Ala 
    530                 535                 540                 


Trp Ser Gly Ser Ser Cys Lys His Val Ser Leu Tyr Gln Pro Gln Leu 
545                 550                 555                 560 


Ala Thr Arg Pro Trp Ile Gln Asp Ile Glu Gly Ala Ser Ala Lys Asp 
                565                 570                 575     


Leu Cys Ser Ala Ser Ser Val Val Ser Pro Ser Phe Val Pro Thr Gly 
            580                 585                 590         


Glu Lys Pro Cys Glu Gln Val Gln Phe Gln Pro Asn Thr Val Asn Thr 
        595                 600                 605             


Leu Ala Cys Pro Leu Leu Ser Asn Leu Ala Thr Arg Leu Trp Leu Arg 
    610                 615                 620                 


Asn Gly Ala Pro Val Asn Ala Ser Ala Ser Cys His Val Leu Pro Thr 
625                 630                 635                 640 


Gly Asp Leu Leu Leu Val Gly Thr Gln Gln Leu Gly Glu Phe Gln Cys 
                645                 650                 655     


Trp Ser Leu Glu Glu Gly Phe Gln Gln Leu Val Ala Ser Tyr Cys Pro 
            660                 665                 670         


Glu Val Val Glu Asp Gly Val Ala Asp Gln Thr Asp Glu Gly Gly Ser 
        675                 680                 685             


Val Pro Val Ile Ile Ser Thr Ser Arg Val Ser Ala Pro Ala Gly Gly 
    690                 695                 700                 


Lys Ala Ser Trp Gly Ala Asp Arg Ser Tyr Trp Lys Glu Phe Leu Val 
705                 710                 715                 720 


Met Cys Thr Leu Phe Val Leu Ala Val Leu Leu Pro Val Leu Phe Leu 
                725                 730                 735     


Leu Tyr Arg His Arg Asn Ser Met Lys Val Phe Leu Lys Gln Gly Glu 
            740                 745                 750         


Cys Ala Ser Val His Pro Lys Thr Cys Pro Val Val Leu Pro Pro Glu 
        755                 760                 765             


Thr Arg Pro Leu Asn Gly Leu Gly Pro Pro Ser Thr Pro Leu Asp His 
    770                 775                 780                 


Arg Gly Tyr Gln Ser Leu Ser Asp Ser Pro Pro Gly Ser Arg Val Phe 
785                 790                 795                 800 


Thr Glu Ser Glu Lys Arg Pro Leu Ser Ile Gln Asp Ser Phe Val Glu 
                805                 810                 815     


Val Ser Pro Val Cys Pro Arg Pro Arg Val Arg Leu Gly Ser Glu Ile 
            820                 825                 830         


Arg Asp Ser Val Val 
        835         


<210>  4619
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  4619

Met Glu Ile Pro Met Gly Thr Gln Gly Cys Phe Ser Lys Ser Leu Leu 
1               5                   10                  15      


Leu Ser Ala Ser Ile Leu Val Leu Trp Met Leu Gln Gly Ser Gln Ala 
            20                  25                  30          


Ala Leu Tyr Ile Gln Lys Ile Pro Glu Gln Pro Gln Lys Asn Gln Asp 
        35                  40                  45              


Leu Leu Leu Ser Val Gln Gly Val Pro Asp Thr Phe Gln Asp Phe Asn 
    50                  55                  60                  


Trp Tyr Leu Gly Glu Glu Thr Tyr Gly Gly Thr Arg Leu Phe Thr Tyr 
65                  70                  75                  80  


Ile Pro Gly Ile Gln Arg Pro Gln Arg Asp Gly Ser Ala Met Gly Gln 
                85                  90                  95      


Arg Asp Ile Val Gly Phe Pro Asn Gly Ser Met Leu Leu Arg Arg Ala 
            100                 105                 110         


Gln Pro Thr Asp Ser Gly Thr Tyr Gln Val Ala Ile Thr Ile Asn Ser 
        115                 120                 125             


Glu Trp Thr Met Lys Ala Lys Thr Glu Val Gln Val Ala Glu Lys Asn 
    130                 135                 140                 


Lys Glu Leu Pro Ser Thr His Leu Pro Thr Asn Ala Gly Ile Leu Ala 
145                 150                 155                 160 


Ala Thr Ile Ile Gly Ser Leu Ala Ala Gly Ala Leu Leu Ile Ser Cys 
                165                 170                 175     


Ile Ala Tyr Leu Leu Val Thr Arg Asn Trp Arg Gly Gln Ser His Arg 
            180                 185                 190         


Leu Pro Ala Pro Arg Gly Gln Gly Ser Leu Ser Ile Leu Cys Ser Ala 
        195                 200                 205             


Val Ser Pro Val Pro Ser Val Thr Pro Ser Thr Trp Met Ala Thr Thr 
    210                 215                 220                 


Glu Lys Pro Glu Leu Gly Pro Ala His Asp Ala Gly Asp Asn Asn Ile 
225                 230                 235                 240 


Tyr Glu Val Met Pro Ser Pro Val Leu Leu Val Ser Pro Ile Ser Asp 
                245                 250                 255     


Thr Arg Ser Ile Asn Pro Ala Arg Pro Leu Pro Thr Pro Pro His Leu 
            260                 265                 270         


Gln Ala Glu Pro Glu Asn His Gln Tyr Gln Gln Asp Leu Leu Asn Pro 
        275                 280                 285             


Asp Pro Ala Pro Tyr Cys Gln Leu Val Pro Thr Ser 
    290                 295                 300 


<210>  4620
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  4620

Met Lys Met Met Leu Val Arg Arg Phe Arg Val Leu Ile Leu Met Val 
1               5                   10                  15      


Phe Leu Val Ala Cys Ala Leu His Ile Ala Leu Asp Leu Leu Pro Arg 
            20                  25                  30          


Leu Glu Arg Arg Gly Ala Arg Pro Ser Gly Glu Pro Gly Cys Ser Cys 
        35                  40                  45              


Ala Gln Pro Ala Ala Glu Val Ala Ala Pro Gly Trp Ala Gln Val Arg 
    50                  55                  60                  


Gly Arg Pro Gly Glu Pro Pro Ala Ala Ser Ser Ala Ala Gly Asp Ala 
65                  70                  75                  80  


Gly Trp Pro Asn Lys His Thr Leu Arg Ile Leu Gln Asp Phe Ser Ser 
                85                  90                  95      


Asp Pro Ser Ser Asn Leu Ser Ser His Ser Leu Glu Lys Leu Pro Pro 
            100                 105                 110         


Ala Ala Glu Pro Ala Glu Arg Ala Leu Arg Gly Arg Asp Pro Gly Ala 
        115                 120                 125             


Leu Arg Pro His Asp Pro Ala His Arg Pro Leu Leu Arg Asp Pro Gly 
    130                 135                 140                 


Pro Arg Arg Ser Glu Ser Pro Pro Gly Pro Gly Gly Asp Ala Ser Leu 
145                 150                 155                 160 


Leu Ala Arg Leu Phe Glu His Pro Leu Tyr Arg Val Ala Val Pro Pro 
                165                 170                 175     


Leu Thr Glu Glu Asp Val Leu Phe Asn Val Asn Ser Asp Thr Arg Leu 
            180                 185                 190         


Ser Pro Lys Ala Ala Glu Asn Pro Asp Trp Pro His Ala Gly Ala Glu 
        195                 200                 205             


Gly Ala Glu Phe Leu Ser Pro Gly Glu Ala Ala Val Asp Ser Tyr Pro 
    210                 215                 220                 


Asn Trp Leu Lys Phe His Ile Gly Ile Asn Arg Tyr Glu Leu Tyr Ser 
225                 230                 235                 240 


Arg His Asn Pro Ala Ile Glu Ala Leu Leu His Asp Leu Ser Ser Gln 
                245                 250                 255     


Arg Ile Thr Ser Val Ala Met Lys Ser Gly Gly Thr Gln Leu Lys Leu 
            260                 265                 270         


Ile Met Thr Phe Gln Asn Tyr Gly Gln Ala Leu Phe Lys Pro Met Lys 
        275                 280                 285             


Gln Thr Arg Glu Gln Glu Thr Pro Pro Asp Phe Phe Tyr Phe Ser Asp 
    290                 295                 300                 


Tyr Glu Arg His Asn Ala Glu Ile Ala Ala Phe His Leu Asp Arg Ile 
305                 310                 315                 320 


Leu Asp Phe Arg Arg Val Pro Pro Val Ala Gly Arg Met Val Asn Met 
                325                 330                 335     


Thr Lys Glu Ile Arg Asp Val Thr Arg Asp Lys Lys Leu Trp Arg Thr 
            340                 345                 350         


Phe Phe Ile Ser Pro Ala Asn Asn Ile Cys Phe Tyr Gly Glu Cys Ser 
        355                 360                 365             


Tyr Tyr Cys Ser Thr Glu His Ala Leu Cys Gly Lys Pro Asp Gln Ile 
    370                 375                 380                 


Glu Gly Ser Leu Ala Ala Phe Leu Pro Asp Leu Ser Leu Ala Lys Arg 
385                 390                 395                 400 


Lys Thr Trp Arg Asn Pro Trp Arg Arg Ser Tyr His Lys Arg Lys Lys 
                405                 410                 415     


Ala Glu Trp Glu Val Asp Pro Asp Tyr Cys Glu Glu Val Lys Gln Thr 
            420                 425                 430         


Pro Pro Tyr Asp Ser Ser His Arg Ile Leu Asp Val Met Asp Met Thr 
        435                 440                 445             


Ile Phe Asp Phe Leu Met Gly Asn Met Asp Arg His His Tyr Glu Thr 
    450                 455                 460                 


Phe Glu Lys Phe Gly Asn Glu Thr Phe Ile Ile His Leu Asp Asn Gly 
465                 470                 475                 480 


Arg Gly Phe Gly Lys Tyr Ser His Asp Glu Leu Ser Ile Leu Val Pro 
                485                 490                 495     


Leu Gln Gln Cys Cys Arg Ile Arg Lys Ser Thr Tyr Leu Arg Leu Gln 
            500                 505                 510         


Leu Leu Ala Lys Glu Glu Tyr Lys Leu Ser Leu Leu Met Ala Glu Ser 
        515                 520                 525             


Leu Arg Gly Asp Gln Val Ala Pro Val Leu Tyr Gln Pro His Leu Glu 
    530                 535                 540                 


Ala Leu Asp Arg Arg Leu Arg Val Val Leu Lys Ala Val Arg Asp Cys 
545                 550                 555                 560 


Val Glu Arg Asn Gly Leu His Ser Val Val Asp Asp Asp Leu Asp Thr 
                565                 570                 575     


Glu His Arg Ala Ala Ser Ala Arg 
            580                 


<210>  4621
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  4621

Met Asp Asp Lys Pro Asn Pro Glu Ala Leu Ser Asp Ser Ser Glu Arg 
1               5                   10                  15      


Leu Phe Ser Phe Gly Val Ile Ala Asp Val Gln Phe Ala Asp Leu Glu 
            20                  25                  30          


Asp Gly Phe Asn Phe Gln Gly Thr Arg Arg Arg Tyr Tyr Arg His Ser 
        35                  40                  45              


Leu Leu His Leu Gln Gly Ala Ile Glu Asp Trp Asn Asn Glu Ser Ser 
    50                  55                  60                  


Met Pro Cys Cys Val Leu Gln Leu Gly Asp Ile Ile Asp Gly Tyr Asn 
65                  70                  75                  80  


Ala Gln Tyr Asn Ala Ser Lys Lys Ser Leu Glu Leu Val Met Asp Met 
                85                  90                  95      


Phe Lys Arg Leu Lys Val Pro Val His His Thr Trp Gly Asn His Glu 
            100                 105                 110         


Phe Tyr Asn Phe Ser Arg Glu Tyr Leu Thr His Ser Lys Leu Asn Thr 
        115                 120                 125             


Lys Phe Leu Glu Asp Gln Ile Val His His Pro Glu Thr Met Pro Ser 
    130                 135                 140                 


Glu Asp Tyr Tyr Ala Tyr His Phe Val Pro Phe Pro Lys Phe Arg Phe 
145                 150                 155                 160 


Ile Leu Leu Asp Ala Tyr Asp Leu Ser Val Leu Gly Val Asp Gln Ser 
                165                 170                 175     


Ser Pro Lys Tyr Glu Gln Cys Met Lys Ile Leu Arg Glu His Asn Pro 
            180                 185                 190         


Asn Thr Glu Leu Asn Ser Pro Gln Gly Leu Ser Glu Pro Gln Phe Val 
        195                 200                 205             


Gln Phe Asn Gly Gly Phe Ser Gln Glu Gln Leu Asn Trp Leu Asn Glu 
    210                 215                 220                 


Val Leu Thr Phe Ser Asp Thr Asn Gln Glu Lys Val Val Ile Val Ser 
225                 230                 235                 240 


His Leu Pro Ile Tyr Pro Asp Ala Ser Asp Asn Val Cys Leu Ala Trp 
                245                 250                 255     


Asn Tyr Arg Asp Ala Leu Ala Val Ile Trp Ser His Glu Cys Val Val 
            260                 265                 270         


Cys Phe Phe Ala Gly His Thr His Asp Gly Gly Tyr Ser Glu Asp Pro 
        275                 280                 285             


Phe Gly Val Tyr His Val Asn Leu Glu Gly Val Ile Glu Thr Ala Pro 
    290                 295                 300                 


Asp Ser Gln Ala Phe Gly Thr Val His Val Tyr Pro Asp Lys Met Met 
305                 310                 315                 320 


Leu Lys Gly Arg Gly Arg Val Pro Asp Arg Ile Met Asn Tyr Lys Lys 
                325                 330                 335     


Glu Arg Ala Phe His Cys 
            340         


<210>  4622
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  4622

Met Ala Ala Gly Ala Gly Ala Gly Ser Ala Pro Arg Trp Leu Arg Ala 
1               5                   10                  15      


Leu Ser Glu Pro Leu Ser Ala Ala Gln Leu Arg Arg Leu Glu Glu His 
            20                  25                  30          


Arg Tyr Ser Ala Ala Gly Val Ser Leu Leu Glu Pro Pro Leu Gln Leu 
        35                  40                  45              


Tyr Trp Thr Trp Leu Leu Gln Trp Ile Pro Leu Trp Met Ala Pro Asn 
    50                  55                  60                  


Ser Ile Thr Leu Leu Gly Leu Ala Val Asn Val Val Thr Thr Leu Val 
65                  70                  75                  80  


Leu Ile Ser Tyr Cys Pro Thr Ala Thr Glu Glu Ala Pro Tyr Trp Thr 
                85                  90                  95      


Tyr Leu Leu Cys Ala Leu Gly Leu Phe Ile Tyr Gln Ser Leu Asp Ala 
            100                 105                 110         


Ile Asp Gly Lys Gln Ala Arg Arg Thr Asn Ser Cys Ser Pro Leu Gly 
        115                 120                 125             


Glu Leu Phe Asp His Gly Cys Asp Ser Leu Ser Thr Val Phe Met Ala 
    130                 135                 140                 


Val Gly Ala Ser Ile Ala Ala Arg Leu Gly Thr Tyr Pro Asp Trp Phe 
145                 150                 155                 160 


Phe Phe Cys Ser Phe Ile Gly Met Phe Val Phe Tyr Cys Ala His Trp 
                165                 170                 175     


Gln Thr Tyr Val Ser Gly Met Leu Arg Phe Gly Lys Val Asp Val Thr 
            180                 185                 190         


Glu Ile Gln Ile Ala Leu Val Ile Val Phe Val Leu Ser Ala Phe Gly 
        195                 200                 205             


Gly Ala Thr Met Trp Asp Tyr Thr Ile Pro Ile Leu Glu Ile Lys Leu 
    210                 215                 220                 


Lys Ile Leu Pro Val Leu Gly Phe Leu Gly Gly Val Ile Phe Ser Cys 
225                 230                 235                 240 


Ser Asn Tyr Phe His Val Ile Leu His Gly Gly Val Gly Lys Asn Gly 
                245                 250                 255     


Ser Thr Ile Ala Gly Thr Ser Val Leu Ser Pro Gly Leu His Ile Gly 
            260                 265                 270         


Leu Ile Ile Ile Leu Ala Ile Met Ile Tyr Lys Lys Ser Ala Thr Asp 
        275                 280                 285             


Val Phe Glu Lys His Pro Cys Leu Tyr Ile Leu Met Phe Gly Cys Val 
    290                 295                 300                 


Phe Ala Lys Val Ser Gln Lys Leu Val Val Ala His Met Thr Lys Ser 
305                 310                 315                 320 


Glu Leu Tyr Leu Gln Asp Thr Val Phe Leu Gly Pro Gly Leu Leu Phe 
                325                 330                 335     


Leu Asp Gln Tyr Phe Asn Asn Phe Ile Asp Glu Tyr Val Val Leu Trp 
            340                 345                 350         


Met Ala Met Val Ile Ser Ser Phe Asp Met Val Ile Tyr Phe Ser Ala 
        355                 360                 365             


Leu Cys Leu Gln Ile Ser Arg His Leu His Leu Asn Ile Phe Lys Thr 
    370                 375                 380                 


Ala Cys His Gln Ala Pro Glu Gln Val Gln Val Leu Ser Ser Lys Ser 
385                 390                 395                 400 


His Gln Asn Asn Met Asp 
                405     


<210>  4623
<211>  914
<212>  PRT
<213>  Homo sapiens

<400>  4623

Met Ala Ser Glu Ser Ser Pro Leu Leu Ala Tyr Arg Leu Leu Gly Glu 
1               5                   10                  15      


Glu Gly Val Ala Leu Pro Ala Asn Gly Ala Gly Gly Pro Gly Gly Ala 
            20                  25                  30          


Ser Ala Arg Lys Leu Ser Thr Phe Leu Gly Val Val Val Pro Thr Val 
        35                  40                  45              


Leu Ser Met Phe Ser Ile Val Val Phe Leu Arg Ile Gly Phe Val Val 
    50                  55                  60                  


Gly His Ala Gly Leu Leu Gln Ala Leu Ala Met Leu Leu Val Ala Tyr 
65                  70                  75                  80  


Phe Ile Leu Ala Leu Thr Val Leu Ser Val Cys Ala Ile Ala Thr Asn 
                85                  90                  95      


Gly Ala Val Gln Gly Gly Gly Ala Tyr Phe Met Ile Ser Arg Thr Leu 
            100                 105                 110         


Gly Pro Glu Val Gly Gly Ser Ile Gly Leu Met Phe Tyr Leu Ala Asn 
        115                 120                 125             


Val Cys Gly Cys Ala Val Ser Leu Leu Gly Leu Val Glu Ser Val Leu 
    130                 135                 140                 


Asp Val Phe Gly Ala Asp Ala Thr Gly Pro Ser Gly Leu Arg Val Leu 
145                 150                 155                 160 


Pro Gln Gly Tyr Gly Trp Asn Leu Leu Tyr Gly Ser Leu Leu Leu Gly 
                165                 170                 175     


Leu Val Gly Gly Val Cys Thr Leu Gly Ala Gly Leu Tyr Ala Arg Ala 
            180                 185                 190         


Ser Phe Leu Thr Phe Leu Leu Val Ser Gly Ser Leu Ala Ser Val Leu 
        195                 200                 205             


Ile Ser Phe Val Ala Val Gly Pro Arg Asp Ile Arg Leu Thr Pro Arg 
    210                 215                 220                 


Pro Gly Pro Asn Gly Ser Ser Leu Pro Pro Arg Phe Gly His Phe Thr 
225                 230                 235                 240 


Gly Phe Asn Ser Ser Thr Leu Lys Asp Asn Leu Gly Ala Gly Tyr Ala 
                245                 250                 255     


Glu Asp Tyr Thr Thr Gly Ala Val Met Asn Phe Ala Ser Val Phe Ala 
            260                 265                 270         


Val Leu Phe Asn Gly Cys Thr Gly Ile Met Ala Gly Ala Asn Met Ser 
        275                 280                 285             


Gly Glu Leu Lys Asp Pro Ser Arg Ala Ile Pro Leu Gly Thr Ile Val 
    290                 295                 300                 


Ala Val Ala Tyr Thr Phe Phe Val Tyr Val Leu Leu Phe Phe Leu Ser 
305                 310                 315                 320 


Ser Phe Thr Cys Asp Arg Thr Leu Leu Gln Glu Asp Tyr Gly Phe Phe 
                325                 330                 335     


Arg Ala Ile Ser Leu Trp Pro Pro Leu Val Leu Ile Gly Ile Tyr Ala 
            340                 345                 350         


Thr Ala Leu Ser Ala Ser Met Ser Ser Leu Ile Gly Ala Ser Arg Ile 
        355                 360                 365             


Leu His Ala Leu Ala Arg Asp Asp Leu Phe Gly Val Ile Leu Ala Pro 
    370                 375                 380                 


Ala Lys Val Val Ser Arg Gly Gly Asn Pro Trp Ala Ala Val Leu Tyr 
385                 390                 395                 400 


Ser Trp Gly Leu Val Gln Leu Val Leu Leu Ala Gly Lys Leu Asn Thr 
                405                 410                 415     


Leu Ala Ala Val Val Thr Val Phe Tyr Leu Val Ala Tyr Ala Ala Val 
            420                 425                 430         


Asp Leu Ser Cys Leu Ser Leu Glu Trp Ala Ser Ala Pro Asn Phe Arg 
        435                 440                 445             


Pro Thr Phe Ser Leu Phe Ser Trp His Thr Cys Leu Leu Gly Val Ala 
    450                 455                 460                 


Ser Cys Leu Leu Met Met Phe Leu Ile Ser Pro Gly Ala Ala Gly Gly 
465                 470                 475                 480 


Ser Leu Leu Leu Met Gly Leu Leu Ala Ala Leu Leu Thr Ala Arg Gly 
                485                 490                 495     


Gly Pro Ser Ser Trp Gly Tyr Val Ser Gln Ala Leu Leu Phe His Gln 
            500                 505                 510         


Val Arg Lys Tyr Leu Leu Arg Leu Asp Val Arg Lys Asp His Val Lys 
        515                 520                 525             


Phe Trp Arg Pro Gln Leu Leu Leu Leu Val Gly Asn Pro Arg Gly Ala 
    530                 535                 540                 


Leu Pro Leu Leu Arg Leu Ala Asn Gln Leu Lys Lys Gly Gly Leu Tyr 
545                 550                 555                 560 


Val Leu Gly His Val Thr Leu Gly Asp Leu Asp Ser Leu Pro Ser Asp 
                565                 570                 575     


Pro Val Gln Pro Gln Tyr Gly Ala Trp Leu Ser Leu Val Asp Arg Ala 
            580                 585                 590         


Gln Val Lys Ala Phe Val Asp Leu Thr Leu Ser Pro Ser Val Arg Gln 
        595                 600                 605             


Gly Ala Gln His Leu Leu Arg Ile Ser Gly Leu Gly Gly Met Lys Pro 
    610                 615                 620                 


Asn Thr Leu Val Leu Gly Phe Tyr Asp Asp Ala Pro Pro Gln Asp His 
625                 630                 635                 640 


Phe Leu Thr Asp Pro Ala Phe Ser Glu Pro Ala Asp Ser Thr Arg Glu 
                645                 650                 655     


Gly Ser Ser Pro Ala Leu Ser Thr Leu Phe Pro Pro Pro Arg Ala Pro 
            660                 665                 670         


Gly Ser Pro Arg Ala Leu Asn Pro Gln Asp Tyr Val Ala Thr Val Ala 
        675                 680                 685             


Asp Ala Leu Lys Met Asn Lys Asn Val Val Leu Ala Arg Ala Ser Gly 
    690                 695                 700                 


Ala Leu Pro Pro Glu Arg Leu Ser Arg Gly Ser Gly Gly Thr Ser Gln 
705                 710                 715                 720 


Leu His His Val Asp Val Trp Pro Leu Asn Leu Leu Arg Pro Arg Gly 
                725                 730                 735     


Gly Pro Gly Tyr Val Asp Val Cys Gly Leu Phe Leu Leu Gln Met Ala 
            740                 745                 750         


Thr Ile Leu Gly Met Val Pro Ala Trp His Ser Ala Arg Leu Arg Ile 
        755                 760                 765             


Phe Leu Cys Leu Gly Pro Arg Glu Ala Pro Gly Ala Ala Glu Gly Arg 
    770                 775                 780                 


Leu Arg Ala Leu Leu Ser Gln Leu Arg Ile Arg Ala Glu Val Gln Glu 
785                 790                 795                 800 


Val Val Trp Gly Glu Gly Ala Gly Ala Gly Glu Pro Glu Ala Glu Glu 
                805                 810                 815     


Glu Gly Asp Phe Val Asn Ser Gly Arg Gly Asp Ala Glu Ala Glu Ala 
            820                 825                 830         


Leu Ala Arg Ser Ala Asn Ala Leu Val Arg Ala Gln Gln Gly Arg Gly 
        835                 840                 845             


Thr Gly Gly Gly Pro Gly Gly Pro Glu Gly Gly Asp Ala Glu Gly Pro 
    850                 855                 860                 


Ile Thr Ala Leu Thr Phe Leu Tyr Leu Pro Arg Pro Pro Ala Asp Pro 
865                 870                 875                 880 


Ala Arg Tyr Pro Arg Tyr Leu Ala Leu Leu Glu Thr Leu Thr Arg Asp 
                885                 890                 895     


Leu Gly Pro Thr Leu Leu Val His Gly Val Thr Pro Val Thr Cys Thr 
            900                 905                 910         


Asp Leu 
        


<210>  4624
<211>  1549
<212>  PRT
<213>  Homo sapiens

<400>  4624

Met Ser Leu Ser Phe Cys Gly Asn Asn Ile Ser Ser Tyr Asn Ile Asn 
1               5                   10                  15      


Asp Gly Val Leu Gln Asn Ser Cys Phe Val Asp Ala Leu Asn Leu Val 
            20                  25                  30          


Pro His Val Phe Leu Leu Phe Ile Thr Phe Pro Ile Leu Phe Ile Gly 
        35                  40                  45              


Trp Gly Ser Gln Ser Ser Lys Val Gln Ile His His Asn Thr Trp Leu 
    50                  55                  60                  


His Phe Pro Gly His Asn Leu Arg Trp Ile Leu Thr Phe Ala Leu Leu 
65                  70                  75                  80  


Phe Val His Val Cys Glu Ile Ala Glu Gly Ile Val Ser Asp Ser Arg 
                85                  90                  95      


Arg Glu Ser Arg His Leu His Leu Phe Met Pro Ala Val Met Gly Phe 
            100                 105                 110         


Val Ala Thr Thr Thr Ser Ile Val Tyr Tyr His Asn Ile Glu Thr Ser 
        115                 120                 125             


Asn Phe Pro Lys Leu Leu Leu Ala Leu Phe Leu Tyr Trp Val Met Ala 
    130                 135                 140                 


Phe Ile Thr Lys Thr Ile Lys Leu Val Lys Tyr Cys Gln Ser Gly Leu 
145                 150                 155                 160 


Asp Ile Ser Asn Leu Arg Phe Cys Ile Thr Gly Met Met Val Ile Leu 
                165                 170                 175     


Asn Gly Leu Leu Met Ala Val Glu Ile Asn Val Ile Arg Val Arg Arg 
            180                 185                 190         


Tyr Val Phe Phe Met Asn Pro Gln Lys Val Lys Pro Pro Glu Asp Leu 
        195                 200                 205             


Gln Asp Leu Gly Val Arg Phe Leu Gln Pro Phe Val Asn Leu Leu Ser 
    210                 215                 220                 


Lys Ala Thr Tyr Trp Trp Met Asn Thr Leu Ile Ile Ser Ala His Lys 
225                 230                 235                 240 


Lys Pro Ile Asp Leu Lys Ala Ile Gly Lys Leu Pro Ile Ala Met Arg 
                245                 250                 255     


Ala Val Thr Asn Tyr Val Cys Leu Lys Asp Ala Tyr Glu Glu Gln Lys 
            260                 265                 270         


Lys Lys Val Ala Asp His Pro Asn Arg Thr Pro Ser Ile Trp Leu Ala 
        275                 280                 285             


Met Tyr Arg Ala Phe Gly Arg Pro Ile Leu Leu Ser Ser Thr Phe Arg 
    290                 295                 300                 


Tyr Leu Ala Asp Leu Leu Gly Phe Ala Gly Pro Leu Cys Ile Ser Gly 
305                 310                 315                 320 


Ile Val Gln Arg Val Asn Glu Thr Gln Asn Gly Thr Asn Asn Thr Thr 
                325                 330                 335     


Gly Ile Ser Glu Thr Leu Ser Ser Lys Glu Phe Leu Glu Asn Ala Tyr 
            340                 345                 350         


Val Leu Ala Val Leu Leu Phe Leu Ala Leu Ile Leu Gln Arg Thr Phe 
        355                 360                 365             


Leu Gln Ala Ser Tyr Tyr Val Thr Ile Glu Thr Gly Ile Asn Leu Arg 
    370                 375                 380                 


Gly Ala Leu Leu Ala Met Ile Tyr Asn Lys Ile Leu Arg Leu Ser Thr 
385                 390                 395                 400 


Ser Asn Leu Ser Met Gly Glu Met Thr Leu Gly Gln Ile Asn Asn Leu 
                405                 410                 415     


Val Ala Ile Glu Thr Asn Gln Leu Met Trp Phe Leu Phe Leu Cys Pro 
            420                 425                 430         


Asn Leu Trp Ala Met Pro Val Gln Ile Ile Met Gly Val Ile Leu Leu 
        435                 440                 445             


Tyr Asn Leu Leu Gly Ser Ser Ala Leu Val Gly Ala Ala Val Ile Val 
    450                 455                 460                 


Leu Leu Ala Pro Ile Gln Tyr Phe Ile Ala Thr Lys Leu Ala Glu Ala 
465                 470                 475                 480 


Gln Lys Ser Thr Leu Asp Tyr Ser Thr Glu Arg Leu Lys Lys Thr Asn 
                485                 490                 495     


Glu Ile Leu Lys Gly Ile Lys Leu Leu Lys Leu Tyr Ala Trp Glu His 
            500                 505                 510         


Ile Phe Cys Lys Ser Val Glu Glu Thr Arg Met Lys Glu Leu Ser Ser 
        515                 520                 525             


Leu Lys Thr Phe Ala Leu Tyr Thr Ser Leu Ser Ile Phe Met Asn Ala 
    530                 535                 540                 


Ala Ile Pro Ile Ala Ala Val Leu Ala Thr Phe Val Thr His Ala Tyr 
545                 550                 555                 560 


Ala Ser Gly Asn Asn Leu Lys Pro Ala Glu Ala Phe Ala Ser Leu Ser 
                565                 570                 575     


Leu Phe His Ile Leu Val Thr Pro Leu Phe Leu Leu Ser Thr Val Val 
            580                 585                 590         


Arg Phe Ala Val Lys Ala Ile Ile Ser Val Gln Lys Leu Asn Glu Phe 
        595                 600                 605             


Leu Leu Ser Asp Glu Ile Gly Asp Asp Ser Trp Arg Thr Gly Glu Ser 
    610                 615                 620                 


Ser Leu Pro Phe Glu Ser Cys Lys Lys His Thr Gly Val Gln Pro Lys 
625                 630                 635                 640 


Thr Ile Asn Arg Lys Gln Pro Gly Arg Tyr His Leu Asp Ser Tyr Glu 
                645                 650                 655     


Gln Ser Thr Arg Arg Leu Arg Pro Ala Glu Thr Glu Asp Ile Ala Ile 
            660                 665                 670         


Lys Val Thr Asn Gly Tyr Phe Ser Trp Gly Ser Gly Leu Ala Thr Leu 
        675                 680                 685             


Ser Asn Ile Asp Ile Arg Ile Pro Thr Gly Gln Leu Thr Met Ile Val 
    690                 695                 700                 


Gly Gln Val Gly Cys Gly Lys Ser Ser Leu Leu Leu Ala Ile Leu Gly 
705                 710                 715                 720 


Glu Met Gln Thr Leu Glu Gly Lys Val His Trp Ser Asn Val Asn Glu 
                725                 730                 735     


Ser Glu Pro Ser Phe Glu Ala Thr Arg Ser Arg Asn Arg Tyr Ser Val 
            740                 745                 750         


Ala Tyr Ala Ala Gln Lys Pro Trp Leu Leu Asn Ala Thr Val Glu Glu 
        755                 760                 765             


Asn Ile Thr Phe Gly Ser Pro Phe Asn Lys Gln Arg Tyr Lys Ala Val 
    770                 775                 780                 


Thr Asp Ala Cys Ser Leu Gln Pro Asp Ile Asp Leu Leu Pro Phe Gly 
785                 790                 795                 800 


Asp Gln Thr Glu Ile Gly Glu Arg Gly Ile Asn Leu Ser Gly Gly Gln 
                805                 810                 815     


Arg Gln Arg Ile Cys Val Ala Arg Ala Leu Tyr Gln Asn Thr Asn Ile 
            820                 825                 830         


Val Phe Leu Asp Asp Pro Phe Ser Ala Leu Asp Ile His Leu Ser Asp 
        835                 840                 845             


His Leu Met Gln Glu Gly Ile Leu Lys Phe Leu Gln Asp Asp Lys Arg 
    850                 855                 860                 


Thr Leu Val Leu Val Thr His Lys Leu Gln Tyr Leu Thr His Ala Asp 
865                 870                 875                 880 


Trp Ile Ile Ala Met Lys Asp Gly Ser Val Leu Arg Glu Gly Thr Leu 
                885                 890                 895     


Lys Asp Ile Gln Thr Lys Asp Val Glu Leu Tyr Glu His Trp Lys Thr 
            900                 905                 910         


Leu Met Asn Arg Gln Asp Gln Glu Leu Glu Lys Asp Met Glu Ala Asp 
        915                 920                 925             


Gln Thr Thr Leu Glu Arg Lys Thr Leu Arg Arg Ala Met Tyr Ser Arg 
    930                 935                 940                 


Glu Ala Lys Ala Gln Met Glu Asp Glu Asp Glu Glu Glu Glu Glu Glu 
945                 950                 955                 960 


Glu Asp Glu Asp Asp Asn Met Ser Thr Val Met Arg Leu Arg Thr Lys 
                965                 970                 975     


Met Pro Trp Lys Thr Cys Trp Arg Tyr Leu Thr Ser Gly Gly Phe Phe 
            980                 985                 990         


Leu Leu Ile Leu Met Ile Phe Ser  Lys Leu Leu Lys His  Ser Val Ile 
        995                 1000                 1005             


Val Ala  Ile Asp Tyr Trp Leu  Ala Thr Trp Thr Ser  Glu Tyr Ser 
    1010                 1015                 1020             


Ile Asn  Asn Thr Gly Lys Ala  Asp Gln Thr Tyr Tyr  Val Ala Gly 
    1025                 1030                 1035             


Phe Ser  Ile Leu Cys Gly Ala  Gly Ile Phe Leu Cys  Leu Val Thr 
    1040                 1045                 1050             


Ser Leu  Thr Val Glu Trp Met  Gly Leu Thr Ala Ala  Lys Asn Leu 
    1055                 1060                 1065             


His His  Asn Leu Leu Asn Lys  Ile Ile Leu Gly Pro  Ile Arg Phe 
    1070                 1075                 1080             


Phe Asp  Thr Thr Pro Leu Gly  Leu Ile Leu Asn Arg  Phe Ser Ala 
    1085                 1090                 1095             


Asp Thr  Asn Ile Ile Asp Gln  His Ile Pro Pro Thr  Leu Glu Ser 
    1100                 1105                 1110             


Leu Thr  Arg Ser Thr Leu Leu  Cys Leu Ser Ala Ile  Gly Met Ile 
    1115                 1120                 1125             


Ser Tyr  Ala Thr Pro Val Phe  Leu Val Ala Leu Leu  Pro Leu Gly 
    1130                 1135                 1140             


Val Ala  Phe Tyr Phe Ile Gln  Lys Tyr Phe Arg Val  Ala Ser Lys 
    1145                 1150                 1155             


Asp Leu  Gln Glu Leu Asp Asp  Ser Thr Gln Leu Pro  Leu Leu Cys 
    1160                 1165                 1170             


His Phe  Ser Glu Thr Ala Glu  Gly Leu Thr Thr Ile  Arg Ala Phe 
    1175                 1180                 1185             


Arg His  Glu Thr Arg Phe Lys  Gln Arg Met Leu Glu  Leu Thr Asp 
    1190                 1195                 1200             


Thr Asn  Asn Ile Ala Tyr Leu  Phe Leu Ser Ala Ala  Asn Arg Trp 
    1205                 1210                 1215             


Leu Glu  Val Arg Thr Asp Tyr  Leu Gly Ala Cys Ile  Val Leu Thr 
    1220                 1225                 1230             


Ala Ser  Ile Ala Ser Ile Ser  Gly Ser Ser Asn Ser  Gly Leu Val 
    1235                 1240                 1245             


Gly Leu  Gly Leu Leu Tyr Ala  Leu Thr Ile Thr Asn  Tyr Leu Asn 
    1250                 1255                 1260             


Trp Val  Val Arg Asn Leu Ala  Asp Leu Glu Val Gln  Met Gly Ala 
    1265                 1270                 1275             


Val Lys  Lys Val Asn Ser Phe  Leu Thr Met Glu Ser  Glu Asn Tyr 
    1280                 1285                 1290             


Glu Gly  Thr Met Asp Pro Ser  Gln Val Pro Glu His  Trp Pro Gln 
    1295                 1300                 1305             


Glu Gly  Glu Ile Lys Ile His  Asp Leu Cys Val Arg  Tyr Glu Asn 
    1310                 1315                 1320             


Asn Leu  Lys Pro Val Leu Lys  His Val Lys Ala Tyr  Ile Lys Pro 
    1325                 1330                 1335             


Gly Gln  Lys Val Gly Ile Cys  Gly Arg Thr Gly Ser  Gly Lys Ser 
    1340                 1345                 1350             


Ser Leu  Ser Leu Ala Phe Phe  Arg Met Val Asp Ile  Phe Asp Gly 
    1355                 1360                 1365             


Lys Ile  Val Ile Asp Gly Ile  Asp Ile Ser Lys Leu  Pro Leu His 
    1370                 1375                 1380             


Thr Leu  Arg Ser Arg Leu Ser  Ile Ile Leu Gln Asp  Pro Ile Leu 
    1385                 1390                 1395             


Phe Ser  Gly Ser Ile Arg Phe  Asn Leu Asp Pro Glu  Cys Lys Cys 
    1400                 1405                 1410             


Thr Asp  Asp Arg Leu Trp Glu  Ala Leu Glu Ile Ala  Gln Leu Lys 
    1415                 1420                 1425             


Asn Met  Val Lys Ser Leu Pro  Gly Gly Leu Asp Ala  Val Val Thr 
    1430                 1435                 1440             


Glu Gly  Gly Glu Asn Phe Ser  Val Gly Gln Arg Gln  Leu Phe Cys 
    1445                 1450                 1455             


Leu Ala  Arg Ala Phe Val Arg  Lys Ser Ser Ile Leu  Ile Met Asp 
    1460                 1465                 1470             


Glu Ala  Thr Ala Ser Ile Asp  Met Ala Thr Glu Asn  Ile Leu Gln 
    1475                 1480                 1485             


Lys Val  Val Met Thr Ala Phe  Ala Asp Arg Thr Val  Val Thr Ile 
    1490                 1495                 1500             


Ala His  Arg Val Ser Ser Ile  Met Asp Ala Gly Leu  Val Leu Val 
    1505                 1510                 1515             


Phe Ser  Glu Gly Ile Leu Val  Glu Cys Asp Thr Val  Pro Asn Leu 
    1520                 1525                 1530             


Leu Ala  His Lys Asn Gly Leu  Phe Ser Thr Leu Val  Met Thr Asn 
    1535                 1540                 1545             


Lys 
    


<210>  4625
<211>  1549
<212>  PRT
<213>  Homo sapiens

<400>  4625

Met Ser Leu Ser Phe Cys Gly Asn Asn Ile Ser Ser Tyr Asn Ile Asn 
1               5                   10                  15      


Asp Gly Val Leu Gln Asn Ser Cys Phe Val Asp Ala Leu Asn Leu Val 
            20                  25                  30          


Pro His Val Phe Leu Leu Phe Ile Thr Phe Pro Ile Leu Phe Ile Gly 
        35                  40                  45              


Trp Gly Ser Gln Ser Ser Lys Val Gln Ile His His Asn Thr Trp Leu 
    50                  55                  60                  


His Phe Pro Gly His Asn Leu Arg Trp Ile Leu Thr Phe Ala Leu Leu 
65                  70                  75                  80  


Phe Val His Val Cys Glu Ile Ala Glu Gly Ile Val Ser Asp Ser Arg 
                85                  90                  95      


Arg Glu Ser Arg His Leu His Leu Phe Met Pro Ala Val Met Gly Phe 
            100                 105                 110         


Val Ala Thr Thr Thr Ser Ile Val Tyr Tyr His Asn Ile Glu Thr Ser 
        115                 120                 125             


Asn Phe Pro Lys Leu Leu Leu Ala Leu Phe Leu Tyr Trp Val Met Ala 
    130                 135                 140                 


Phe Ile Thr Lys Thr Ile Lys Leu Val Lys Tyr Cys Gln Ser Gly Leu 
145                 150                 155                 160 


Asp Ile Ser Asn Leu Arg Phe Cys Ile Thr Gly Met Met Val Ile Leu 
                165                 170                 175     


Asn Gly Leu Leu Met Ala Val Glu Ile Asn Val Ile Arg Val Arg Arg 
            180                 185                 190         


Tyr Val Phe Phe Met Asn Pro Gln Lys Val Lys Pro Pro Glu Asp Leu 
        195                 200                 205             


Gln Asp Leu Gly Val Arg Phe Leu Gln Pro Phe Val Asn Leu Leu Ser 
    210                 215                 220                 


Lys Ala Thr Tyr Trp Trp Met Asn Thr Leu Ile Ile Ser Ala His Lys 
225                 230                 235                 240 


Lys Pro Ile Asp Leu Lys Ala Ile Gly Lys Leu Pro Ile Ala Met Arg 
                245                 250                 255     


Ala Val Thr Asn Tyr Val Cys Leu Lys Asp Ala Tyr Glu Glu Gln Lys 
            260                 265                 270         


Lys Lys Val Ala Asp His Pro Asn Arg Thr Pro Ser Ile Trp Leu Ala 
        275                 280                 285             


Met Tyr Arg Ala Phe Gly Arg Pro Ile Leu Leu Ser Ser Thr Phe Arg 
    290                 295                 300                 


Tyr Leu Ala Asp Leu Leu Gly Phe Ala Gly Pro Leu Cys Ile Ser Gly 
305                 310                 315                 320 


Ile Val Gln Arg Val Asn Glu Thr Gln Asn Gly Thr Asn Asn Thr Thr 
                325                 330                 335     


Gly Ile Ser Glu Thr Leu Ser Ser Lys Glu Phe Leu Glu Asn Ala Tyr 
            340                 345                 350         


Val Leu Ala Val Leu Leu Phe Leu Ala Leu Ile Leu Gln Arg Thr Phe 
        355                 360                 365             


Leu Gln Ala Ser Tyr Tyr Val Thr Ile Glu Thr Gly Ile Asn Leu Arg 
    370                 375                 380                 


Gly Ala Leu Leu Ala Met Ile Tyr Asn Lys Ile Leu Arg Leu Ser Thr 
385                 390                 395                 400 


Ser Asn Leu Ser Met Gly Glu Met Thr Leu Gly Gln Ile Asn Asn Leu 
                405                 410                 415     


Val Ala Ile Glu Thr Asn Gln Leu Met Trp Phe Leu Phe Leu Cys Pro 
            420                 425                 430         


Asn Leu Trp Ala Met Pro Val Gln Ile Ile Met Gly Val Ile Leu Leu 
        435                 440                 445             


Tyr Asn Leu Leu Gly Ser Ser Ala Leu Val Gly Ala Ala Val Ile Val 
    450                 455                 460                 


Leu Leu Ala Pro Ile Gln Tyr Phe Ile Ala Thr Lys Leu Ala Glu Ala 
465                 470                 475                 480 


Gln Lys Ser Thr Leu Asp Tyr Ser Thr Glu Arg Leu Lys Lys Thr Asn 
                485                 490                 495     


Glu Ile Leu Lys Gly Ile Lys Leu Leu Lys Leu Tyr Ala Trp Glu His 
            500                 505                 510         


Ile Phe Cys Lys Ser Val Glu Glu Thr Arg Met Lys Glu Leu Ser Ser 
        515                 520                 525             


Leu Lys Thr Phe Ala Leu Tyr Thr Ser Leu Ser Ile Phe Met Asn Ala 
    530                 535                 540                 


Ala Ile Pro Ile Ala Ala Val Leu Ala Thr Phe Val Thr His Ala Tyr 
545                 550                 555                 560 


Ala Ser Gly Asn Asn Leu Lys Pro Ala Glu Ala Phe Ala Ser Leu Ser 
                565                 570                 575     


Leu Phe His Ile Leu Val Thr Pro Leu Phe Leu Leu Ser Thr Val Val 
            580                 585                 590         


Arg Phe Ala Val Lys Ala Ile Ile Ser Val Gln Lys Leu Asn Glu Phe 
        595                 600                 605             


Leu Leu Ser Asp Glu Ile Gly Asp Asp Ser Trp Arg Thr Gly Glu Ser 
    610                 615                 620                 


Ser Leu Pro Phe Glu Ser Cys Lys Lys His Thr Gly Val Gln Pro Lys 
625                 630                 635                 640 


Thr Ile Asn Arg Lys Gln Pro Gly Arg Tyr His Leu Asp Ser Tyr Glu 
                645                 650                 655     


Gln Ser Thr Arg Arg Leu Arg Pro Ala Glu Thr Glu Asp Ile Ala Ile 
            660                 665                 670         


Lys Val Thr Asn Gly Tyr Phe Ser Trp Gly Ser Gly Leu Ala Thr Leu 
        675                 680                 685             


Ser Asn Ile Asp Ile Arg Ile Pro Thr Gly Gln Leu Thr Met Ile Val 
    690                 695                 700                 


Gly Gln Val Gly Cys Gly Lys Ser Ser Leu Leu Leu Ala Ile Leu Gly 
705                 710                 715                 720 


Glu Met Gln Thr Leu Glu Gly Lys Val His Trp Ser Asn Val Asn Glu 
                725                 730                 735     


Ser Glu Pro Ser Phe Glu Ala Thr Arg Ser Arg Asn Arg Tyr Ser Val 
            740                 745                 750         


Ala Tyr Ala Ala Gln Lys Pro Trp Leu Leu Asn Ala Thr Val Glu Glu 
        755                 760                 765             


Asn Ile Thr Phe Gly Ser Pro Phe Asn Lys Gln Arg Tyr Lys Ala Val 
    770                 775                 780                 


Thr Asp Ala Cys Ser Leu Gln Pro Asp Ile Asp Leu Leu Pro Phe Gly 
785                 790                 795                 800 


Asp Gln Thr Glu Ile Gly Glu Arg Gly Ile Asn Leu Ser Gly Gly Gln 
                805                 810                 815     


Arg Gln Arg Ile Cys Val Ala Arg Ala Leu Tyr Gln Asn Thr Asn Ile 
            820                 825                 830         


Val Phe Leu Asp Asp Pro Phe Ser Ala Leu Asp Ile His Leu Ser Asp 
        835                 840                 845             


His Leu Met Gln Glu Gly Ile Leu Lys Phe Leu Gln Asp Asp Lys Arg 
    850                 855                 860                 


Thr Leu Val Leu Val Thr His Lys Leu Gln Tyr Leu Thr His Ala Asp 
865                 870                 875                 880 


Trp Ile Ile Ala Met Lys Asp Gly Ser Val Leu Arg Glu Gly Thr Leu 
                885                 890                 895     


Lys Asp Ile Gln Thr Lys Asp Val Glu Leu Tyr Glu His Trp Lys Thr 
            900                 905                 910         


Leu Met Asn Arg Gln Asp Gln Glu Leu Glu Lys Asp Met Glu Ala Asp 
        915                 920                 925             


Gln Thr Thr Leu Glu Arg Lys Thr Leu Arg Arg Ala Met Tyr Ser Arg 
    930                 935                 940                 


Glu Ala Lys Ala Gln Met Glu Asp Glu Asp Glu Glu Glu Glu Glu Glu 
945                 950                 955                 960 


Glu Asp Glu Asp Asp Asn Met Ser Thr Val Met Arg Leu Arg Thr Lys 
                965                 970                 975     


Met Pro Trp Lys Thr Cys Trp Arg Tyr Leu Thr Ser Gly Gly Phe Phe 
            980                 985                 990         


Leu Leu Ile Leu Met Ile Phe Ser  Lys Leu Leu Lys His  Ser Val Ile 
        995                 1000                 1005             


Val Ala  Ile Asp Tyr Trp Leu  Ala Thr Trp Thr Ser  Glu Tyr Ser 
    1010                 1015                 1020             


Ile Asn  Asn Thr Gly Lys Ala  Asp Gln Thr Tyr Tyr  Val Ala Gly 
    1025                 1030                 1035             


Phe Ser  Ile Leu Cys Gly Ala  Gly Ile Phe Leu Cys  Leu Val Thr 
    1040                 1045                 1050             


Ser Leu  Thr Val Glu Trp Met  Gly Leu Thr Ala Ala  Lys Asn Leu 
    1055                 1060                 1065             


His His  Asn Leu Leu Asn Lys  Ile Ile Leu Gly Pro  Ile Arg Phe 
    1070                 1075                 1080             


Phe Asp  Thr Thr Pro Leu Gly  Leu Ile Leu Asn Arg  Phe Ser Ala 
    1085                 1090                 1095             


Asp Thr  Asn Ile Ile Asp Gln  His Ile Pro Pro Thr  Leu Glu Ser 
    1100                 1105                 1110             


Leu Thr  Arg Ser Thr Leu Leu  Cys Leu Ser Ala Ile  Gly Met Ile 
    1115                 1120                 1125             


Ser Tyr  Ala Thr Pro Val Phe  Leu Val Ala Leu Leu  Pro Leu Gly 
    1130                 1135                 1140             


Val Ala  Phe Tyr Phe Ile Gln  Lys Tyr Phe Arg Val  Ala Ser Lys 
    1145                 1150                 1155             


Asp Leu  Gln Glu Leu Asp Asp  Ser Thr Gln Leu Pro  Leu Leu Cys 
    1160                 1165                 1170             


His Phe  Ser Glu Thr Ala Glu  Gly Leu Thr Thr Ile  Arg Ala Phe 
    1175                 1180                 1185             


Arg His  Glu Thr Arg Phe Lys  Gln Arg Met Leu Glu  Leu Thr Asp 
    1190                 1195                 1200             


Thr Asn  Asn Ile Ala Tyr Leu  Phe Leu Ser Ala Ala  Asn Arg Trp 
    1205                 1210                 1215             


Leu Glu  Val Arg Thr Asp Tyr  Leu Gly Ala Cys Ile  Val Leu Thr 
    1220                 1225                 1230             


Ala Ser  Ile Ala Ser Ile Ser  Gly Ser Ser Asn Ser  Gly Leu Val 
    1235                 1240                 1245             


Gly Leu  Gly Leu Leu Tyr Ala  Leu Thr Ile Thr Asn  Tyr Leu Asn 
    1250                 1255                 1260             


Trp Val  Val Arg Asn Leu Ala  Asp Leu Glu Val Gln  Met Gly Ala 
    1265                 1270                 1275             


Val Lys  Lys Val Asn Ser Phe  Leu Thr Met Glu Ser  Glu Asn Tyr 
    1280                 1285                 1290             


Glu Gly  Thr Met Asp Pro Ser  Gln Val Pro Glu His  Trp Pro Gln 
    1295                 1300                 1305             


Glu Gly  Glu Ile Lys Ile His  Asp Leu Cys Val Arg  Tyr Glu Asn 
    1310                 1315                 1320             


Asn Leu  Lys Pro Val Leu Lys  His Val Lys Ala Tyr  Ile Lys Pro 
    1325                 1330                 1335             


Gly Gln  Lys Val Gly Ile Cys  Gly Arg Thr Gly Ser  Gly Lys Ser 
    1340                 1345                 1350             


Ser Leu  Ser Leu Ala Phe Phe  Arg Met Val Asp Ile  Phe Asp Gly 
    1355                 1360                 1365             


Lys Ile  Val Ile Asp Gly Ile  Asp Ile Ser Lys Leu  Pro Leu His 
    1370                 1375                 1380             


Thr Leu  Arg Ser Arg Leu Ser  Ile Ile Leu Gln Asp  Pro Ile Leu 
    1385                 1390                 1395             


Phe Ser  Gly Ser Ile Arg Phe  Asn Leu Asp Pro Glu  Cys Lys Cys 
    1400                 1405                 1410             


Thr Asp  Asp Arg Leu Trp Glu  Ala Leu Glu Ile Ala  Gln Leu Lys 
    1415                 1420                 1425             


Asn Met  Val Lys Ser Leu Pro  Gly Gly Leu Asp Ala  Val Val Thr 
    1430                 1435                 1440             


Glu Gly  Gly Glu Asn Phe Ser  Val Gly Gln Arg Gln  Leu Phe Cys 
    1445                 1450                 1455             


Leu Ala  Arg Ala Phe Val Arg  Lys Ser Ser Ile Leu  Ile Met Asp 
    1460                 1465                 1470             


Glu Ala  Thr Ala Ser Ile Asp  Met Ala Thr Glu Asn  Ile Leu Gln 
    1475                 1480                 1485             


Lys Val  Val Met Thr Ala Phe  Ala Asp Arg Thr Val  Val Thr Ile 
    1490                 1495                 1500             


Ala His  Arg Val His Thr Ile  Leu Thr Ala Asp Leu  Val Ile Val 
    1505                 1510                 1515             


Met Lys  Arg Gly Asn Ile Leu  Glu Tyr Asp Thr Pro  Glu Ser Leu 
    1520                 1525                 1530             


Leu Ala  Gln Glu Asn Gly Val  Phe Ala Ser Phe Val  Arg Ala Asp 
    1535                 1540                 1545             


Met 
    


<210>  4626
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  4626

Met Val Asp Leu Thr Gln Val Met Asp Asp Glu Val Phe Met Ala Phe 
1               5                   10                  15      


Ala Ser Tyr Ala Thr Ile Ile Leu Ser Lys Met Met Leu Met Ser Thr 
            20                  25                  30          


Ala Thr Ala Phe Tyr Arg Leu Thr Arg Lys Val Phe Ala Asn Pro Glu 
        35                  40                  45              


Asp Cys Val Ala Phe Gly Lys Gly Glu Asn Ala Lys Lys Tyr Leu Arg 
    50                  55                  60                  


Thr Asp Asp Arg Val Glu Arg Val Arg Arg Ala His Leu Asn Asp Leu 
65                  70                  75                  80  


Glu Asn Ile Ile Pro Phe Leu Gly Ile Gly Leu Leu Tyr Ser Leu Ser 
                85                  90                  95      


Gly Pro Asp Pro Ser Thr Ala Ile Leu His Phe Arg Leu Phe Val Gly 
            100                 105                 110         


Ala Arg Ile Tyr His Thr Ile Ala Tyr Leu Thr Pro Leu Pro Gln Pro 
        115                 120                 125             


Asn Arg Ala Leu Ser Phe Phe Val Gly Tyr Gly Val Thr Leu Ser Met 
    130                 135                 140                 


Ala Tyr Arg Leu Leu Lys Ser Lys Leu Tyr Leu 
145                 150                 155 


<210>  4627
<211>  560
<212>  PRT
<213>  Homo sapiens

<400>  4627

Met Glu Phe Arg Gln Glu Glu Phe Arg Lys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Gly Lys Leu His Arg Leu Leu Glu Lys Arg Gln Glu Gly Ala Glu Thr 
            20                  25                  30          


Leu Glu Leu Ser Ala Asp Gly Arg Pro Val Thr Thr Gln Thr Arg Asp 
        35                  40                  45              


Pro Pro Val Val Asp Cys Thr Cys Phe Gly Leu Pro Arg Arg Tyr Ile 
    50                  55                  60                  


Ile Ala Ile Met Ser Gly Leu Gly Phe Cys Ile Ser Phe Gly Ile Arg 
65                  70                  75                  80  


Cys Asn Leu Gly Val Ala Ile Val Ser Met Val Asn Asn Ser Thr Thr 
                85                  90                  95      


His Arg Gly Gly His Val Val Val Gln Lys Ala Gln Phe Ser Trp Asp 
            100                 105                 110         


Pro Glu Thr Val Gly Leu Ile His Gly Ser Phe Phe Trp Gly Tyr Ile 
        115                 120                 125             


Val Thr Gln Ile Pro Gly Gly Phe Ile Cys Gln Lys Phe Ala Ala Asn 
    130                 135                 140                 


Arg Val Phe Gly Phe Ala Ile Val Ala Thr Ser Thr Leu Asn Met Leu 
145                 150                 155                 160 


Ile Pro Ser Ala Ala Arg Val His Tyr Gly Cys Val Ile Phe Val Arg 
                165                 170                 175     


Ile Leu Gln Gly Leu Val Glu Gly Val Thr Tyr Pro Ala Cys His Gly 
            180                 185                 190         


Ile Trp Ser Lys Trp Ala Pro Pro Leu Glu Arg Ser Arg Leu Ala Thr 
        195                 200                 205             


Thr Ala Phe Cys Gly Ser Tyr Ala Gly Ala Val Val Ala Met Pro Leu 
    210                 215                 220                 


Ala Gly Val Leu Val Gln Tyr Ser Gly Trp Ser Ser Val Phe Tyr Val 
225                 230                 235                 240 


Tyr Gly Ser Phe Gly Ile Phe Trp Tyr Leu Phe Trp Leu Leu Val Ser 
                245                 250                 255     


Tyr Glu Ser Pro Ala Leu His Pro Ser Ile Ser Glu Glu Glu Arg Lys 
            260                 265                 270         


Tyr Ile Glu Asp Ala Ile Gly Glu Ser Ala Lys Leu Met Asn Pro Leu 
        275                 280                 285             


Thr Lys Phe Ser Thr Pro Trp Arg Arg Phe Phe Thr Ser Met Pro Val 
    290                 295                 300                 


Tyr Ala Ile Ile Val Ala Asn Phe Cys Arg Ser Trp Thr Phe Tyr Leu 
305                 310                 315                 320 


Leu Leu Ile Ser Gln Pro Ala Tyr Phe Glu Glu Val Phe Gly Phe Glu 
                325                 330                 335     


Ile Ser Lys Val Gly Leu Val Ser Ala Leu Pro His Leu Val Met Thr 
            340                 345                 350         


Ile Ile Val Pro Ile Gly Gly Gln Ile Ala Asp Phe Leu Arg Ser Arg 
        355                 360                 365             


Arg Ile Met Ser Thr Thr Asn Val Arg Lys Leu Met Asn Cys Gly Gly 
    370                 375                 380                 


Phe Gly Met Glu Ala Thr Leu Leu Leu Val Val Gly Tyr Ser His Ser 
385                 390                 395                 400 


Lys Gly Val Ala Ile Ser Phe Leu Val Leu Ala Val Gly Phe Ser Gly 
                405                 410                 415     


Phe Ala Ile Ser Gly Phe Asn Val Asn His Leu Asp Ile Ala Pro Arg 
            420                 425                 430         


Tyr Ala Ser Ile Leu Met Gly Ile Ser Asn Gly Val Gly Thr Leu Ser 
        435                 440                 445             


Gly Met Val Cys Pro Ile Ile Val Gly Ala Met Thr Lys His Lys Thr 
    450                 455                 460                 


Arg Glu Glu Trp Gln Tyr Val Phe Leu Ile Ala Ser Leu Val His Tyr 
465                 470                 475                 480 


Gly Gly Val Ile Phe Tyr Gly Val Phe Ala Ser Gly Glu Lys Gln Pro 
                485                 490                 495     


Trp Ala Glu Pro Glu Glu Met Ser Glu Glu Lys Cys Gly Phe Val Gly 
            500                 505                 510         


His Asp Gln Leu Ala Gly Ser Asp Asp Ser Glu Met Glu Asp Glu Ala 
        515                 520                 525             


Glu Pro Pro Gly Ala Pro Pro Ala Pro Pro Pro Ser Tyr Gly Ala Thr 
    530                 535                 540                 


His Ser Thr Phe Gln Pro Pro Arg Pro Pro Pro Pro Val Arg Asp Tyr 
545                 550                 555                 560 


<210>  4628
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  4628

Met Asp Leu His Leu Phe Asp Tyr Ser Glu Pro Gly Asn Phe Ser Asp 
1               5                   10                  15      


Ile Ser Trp Pro Cys Asn Ser Ser Asp Cys Ile Val Val Asp Thr Val 
            20                  25                  30          


Met Cys Pro Asn Met Pro Asn Lys Ser Val Leu Leu Tyr Thr Leu Ser 
        35                  40                  45              


Phe Ile Tyr Ile Phe Ile Phe Val Ile Gly Met Ile Ala Asn Ser Val 
    50                  55                  60                  


Val Val Trp Val Asn Ile Gln Ala Lys Thr Thr Gly Tyr Asp Thr His 
65                  70                  75                  80  


Cys Tyr Ile Leu Asn Leu Ala Ile Ala Asp Leu Trp Val Val Leu Thr 
                85                  90                  95      


Ile Pro Val Trp Val Val Ser Leu Val Gln His Asn Gln Trp Pro Met 
            100                 105                 110         


Gly Glu Leu Thr Cys Lys Val Thr His Leu Ile Phe Ser Ile Asn Leu 
        115                 120                 125             


Phe Gly Ser Ile Phe Phe Leu Thr Cys Met Ser Val Asp Arg Tyr Leu 
    130                 135                 140                 


Ser Ile Thr Tyr Phe Thr Asn Thr Pro Ser Ser Arg Lys Lys Met Val 
145                 150                 155                 160 


Arg Arg Val Val Cys Ile Leu Val Trp Leu Leu Ala Phe Cys Val Ser 
                165                 170                 175     


Leu Pro Asp Thr Tyr Tyr Leu Lys Thr Val Thr Ser Ala Ser Asn Asn 
            180                 185                 190         


Glu Thr Tyr Cys Arg Ser Phe Tyr Pro Glu His Ser Ile Lys Glu Trp 
        195                 200                 205             


Leu Ile Gly Met Glu Leu Val Ser Val Val Leu Gly Phe Ala Val Pro 
    210                 215                 220                 


Phe Ser Ile Ile Ala Val Phe Tyr Phe Leu Leu Ala Arg Ala Ile Ser 
225                 230                 235                 240 


Ala Ser Ser Asp Gln Glu Lys His Ser Ser Arg Lys Ile Ile Phe Ser 
                245                 250                 255     


Tyr Val Val Val Phe Leu Val Cys Trp Leu Pro Tyr His Val Ala Val 
            260                 265                 270         


Leu Leu Asp Ile Phe Ser Ile Leu His Tyr Ile Pro Phe Thr Cys Arg 
        275                 280                 285             


Leu Glu His Ala Leu Phe Thr Ala Leu His Val Thr Gln Cys Leu Ser 
    290                 295                 300                 


Leu Val His Cys Cys Val Asn Pro Val Leu Tyr Ser Phe Ile Asn Arg 
305                 310                 315                 320 


Asn Tyr Arg Tyr Glu Leu Met Lys Ala Phe Ile Phe Lys Tyr Ser Ala 
                325                 330                 335     


Lys Thr Gly Leu Thr Lys Leu Ile Asp Ala Ser Arg Val Ser Glu Thr 
            340                 345                 350         


Glu Tyr Ser Ala Leu Glu Gln Ser Thr Lys 
        355                 360         


<210>  4629
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  4629

Met Val Ser Ile Phe Asn Leu Asp Gly Met Glu His His Val Arg Thr 
1               5                   10                  15      


Cys Ile Pro Lys Val Glu Leu Val Pro Ala Gly Lys Pro Phe Tyr Cys 
            20                  25                  30          


Leu Ser Ser Glu Asp Leu Arg Asn Thr His Cys Cys Tyr Thr Asp Tyr 
        35                  40                  45              


Cys Asn Arg Ile Asp Leu Arg Val Pro Ser Gly His Leu Lys Glu Pro 
    50                  55                  60                  


Glu His Pro Ser Met Trp Gly Pro Val Glu Leu Val Gly Ile Ile Ala 
65                  70                  75                  80  


Gly Pro Val Phe Leu Leu Phe Leu Ile Ile Ile Ile Val Phe Leu Val 
                85                  90                  95      


Ile Asn Tyr His Gln Arg Val Tyr His Asn Arg Gln Arg Leu Asp Met 
            100                 105                 110         


Glu Asp Pro Ser Cys Glu Met Cys Leu Ser Lys Asp Lys Thr Leu Gln 
        115                 120                 125             


Asp Leu Val Tyr Asp Leu Ser Thr Ser Gly Ser Gly Ser Gly Leu Pro 
    130                 135                 140                 


Leu Phe Val Gln Arg Thr Val Ala Arg Thr Ile Val Leu Gln Glu Ile 
145                 150                 155                 160 


Ile Gly Lys Gly Arg Phe Gly Glu Val Trp Arg Gly Arg Trp Arg Gly 
                165                 170                 175     


Gly Asp Val Ala Val Lys Ile Phe Ser Ser Arg Glu Glu Arg Ser Trp 
            180                 185                 190         


Phe Arg Glu Ala Glu Ile Tyr Gln Thr Val Met Leu Arg His Glu Asn 
        195                 200                 205             


Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys Asp Asn Gly Thr Trp Thr 
    210                 215                 220                 


Gln Leu Trp Leu Val Ser Asp Tyr His Glu His Gly Ser Leu Phe Asp 
225                 230                 235                 240 


Tyr Leu Asn Arg Tyr Thr Val Thr Ile Glu Gly Met Ile Lys Leu Ala 
                245                 250                 255     


Leu Ser Ala Ala Ser Gly Leu Ala His Leu His Met Glu Ile Val Gly 
            260                 265                 270         


Thr Gln Gly Lys Pro Gly Ile Ala His Arg Asp Leu Lys Ser Lys Asn 
        275                 280                 285             


Ile Leu Val Lys Lys Asn Gly Met Cys Ala Ile Ala Asp Leu Gly Leu 
    290                 295                 300                 


Ala Val Arg His Asp Ala Val Thr Asp Thr Ile Asp Ile Ala Pro Asn 
305                 310                 315                 320 


Gln Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu 
                325                 330                 335     


Thr Ile Asn Met Lys His Phe Asp Ser Phe Lys Cys Ala Asp Ile Tyr 
            340                 345                 350         


Ala Leu Gly Leu Val Tyr Trp Glu Ile Ala Arg Arg Cys Asn Ser Gly 
        355                 360                 365             


Gly Val His Glu Glu Tyr Gln Leu Pro Tyr Tyr Asp Leu Val Pro Ser 
    370                 375                 380                 


Asp Pro Ser Ile Glu Glu Met Arg Lys Val Val Cys Asp Gln Lys Leu 
385                 390                 395                 400 


Arg Pro Asn Ile Pro Asn Trp Trp Gln Ser Tyr Glu Ala Leu Arg Val 
                405                 410                 415     


Met Gly Lys Met Met Arg Glu Cys Trp Tyr Ala Asn Gly Ala Ala Arg 
            420                 425                 430         


Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Ser Gln Leu Ser Val Gln 
        435                 440                 445             


Glu Asp Val Lys Ile 
    450             


<210>  4630
<211>  546
<212>  PRT
<213>  Homo sapiens

<400>  4630

Met Ala Glu Ser Ala Gly Ala Ser Ser Phe Phe Pro Leu Val Val Leu 
1               5                   10                  15      


Leu Leu Ala Gly Ser Gly Gly Ser Gly Pro Arg Gly Val Gln Ala Leu 
            20                  25                  30          


Leu Cys Ala Cys Thr Ser Cys Leu Gln Ala Asn Tyr Thr Cys Glu Thr 
        35                  40                  45              


Asp Gly Ala Cys Met Val Ser Ile Phe Asn Leu Asp Gly Met Glu His 
    50                  55                  60                  


His Val Arg Thr Cys Ile Pro Lys Val Glu Leu Val Pro Ala Gly Lys 
65                  70                  75                  80  


Pro Phe Tyr Cys Leu Ser Ser Glu Asp Leu Arg Asn Thr His Cys Cys 
                85                  90                  95      


Tyr Thr Asp Tyr Cys Asn Arg Ile Asp Leu Arg Val Pro Ser Gly His 
            100                 105                 110         


Leu Lys Glu Pro Glu His Pro Ser Met Trp Gly Pro Val Glu Leu Val 
        115                 120                 125             


Gly Ile Ile Ala Gly Pro Val Phe Leu Leu Phe Leu Ile Ile Ile Ile 
    130                 135                 140                 


Val Phe Leu Val Ile Asn Tyr His Gln Arg Val Tyr His Asn Arg Gln 
145                 150                 155                 160 


Arg Leu Asp Met Glu Asp Pro Ser Cys Glu Met Cys Leu Ser Lys Asp 
                165                 170                 175     


Lys Thr Leu Gln Asp Leu Val Tyr Asp Leu Ser Thr Ser Gly Ser Gly 
            180                 185                 190         


Ser Gly Leu Pro Leu Phe Val Gln Arg Thr Val Ala Arg Thr Ile Val 
        195                 200                 205             


Leu Gln Glu Ile Ile Gly Lys Gly Arg Phe Gly Glu Val Trp Arg Gly 
    210                 215                 220                 


Arg Trp Arg Gly Gly Asp Val Ala Val Lys Ile Phe Ser Ser Arg Glu 
225                 230                 235                 240 


Glu Arg Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Thr Val Met Leu 
                245                 250                 255     


Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys Ala Asp 
            260                 265                 270         


Cys Ser Phe Leu Thr Leu Pro Trp Glu Val Val Met Val Ser Ala Ala 
        275                 280                 285             


Pro Lys Leu Arg Ser Leu Arg Leu Gln Tyr Lys Gly Gly Arg Gly Arg 
    290                 295                 300                 


Ala Arg Phe Leu Phe Pro Leu Asn Asn Gly Thr Trp Thr Gln Leu Trp 
305                 310                 315                 320 


Leu Val Ser Asp Tyr His Glu His Gly Ser Leu Phe Asp Tyr Leu Asn 
                325                 330                 335     


Arg Tyr Thr Val Thr Ile Glu Gly Met Ile Lys Leu Ala Leu Ser Ala 
            340                 345                 350         


Ala Ser Gly Leu Ala His Leu His Met Glu Ile Val Gly Thr Gln Gly 
        355                 360                 365             


Lys Pro Gly Ile Ala His Arg Asp Leu Lys Ser Lys Asn Ile Leu Val 
    370                 375                 380                 


Lys Lys Asn Gly Met Cys Ala Ile Ala Asp Leu Gly Leu Ala Val Arg 
385                 390                 395                 400 


His Asp Ala Val Thr Asp Thr Ile Asp Ile Ala Pro Asn Gln Arg Val 
                405                 410                 415     


Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Thr Ile Asn 
            420                 425                 430         


Met Lys His Phe Asp Ser Phe Lys Cys Ala Asp Ile Tyr Ala Leu Gly 
        435                 440                 445             


Leu Val Tyr Trp Glu Ile Ala Arg Arg Cys Asn Ser Gly Gly Val His 
    450                 455                 460                 


Glu Glu Tyr Gln Leu Pro Tyr Tyr Asp Leu Val Pro Ser Asp Pro Ser 
465                 470                 475                 480 


Ile Glu Glu Met Arg Lys Val Val Cys Asp Gln Lys Leu Arg Pro Asn 
                485                 490                 495     


Ile Pro Asn Trp Trp Gln Ser Tyr Glu Ala Leu Arg Val Met Gly Lys 
            500                 505                 510         


Met Met Arg Glu Cys Trp Tyr Ala Asn Gly Ala Ala Arg Leu Thr Ala 
        515                 520                 525             


Leu Arg Ile Lys Lys Thr Leu Ser Gln Leu Ser Val Gln Glu Asp Val 
    530                 535                 540                 


Lys Ile 
545     


<210>  4631
<211>  521
<212>  PRT
<213>  Homo sapiens

<400>  4631

Met Asp Thr Glu Ser Gln Tyr Ser Gly Tyr Ser Tyr Lys Ser Gly His 
1               5                   10                  15      


Ser Arg Ser Ser Arg Lys His Arg Asp Arg Arg Asp Arg His Arg Ser 
            20                  25                  30          


Lys Ser Arg Asp Gly Gly Arg Gly Asp Lys Ser Val Thr Ile Gln Ala 
        35                  40                  45              


Pro Gly Glu Pro Leu Leu Asp Asn Glu Ser Thr Arg Gly Asp Glu Arg 
    50                  55                  60                  


Asp Asp Asn Trp Gly Glu Thr Thr Thr Val Val Thr Gly Thr Ser Glu 
65                  70                  75                  80  


His Ser Ile Ser His Asp Asp Leu Thr Arg Ile Ala Lys Asp Met Glu 
                85                  90                  95      


Asp Ser Val Pro Leu Asp Cys Ser Arg His Leu Gly Val Ala Ala Gly 
            100                 105                 110         


Ala Thr Leu Ala Leu Leu Ser Phe Leu Thr Pro Leu Ala Phe Leu Leu 
        115                 120                 125             


Leu Pro Pro Leu Leu Trp Arg Glu Glu Leu Glu Pro Cys Gly Thr Ala 
    130                 135                 140                 


Cys Glu Gly Leu Phe Ile Ser Val Ala Phe Lys Leu Leu Ile Leu Leu 
145                 150                 155                 160 


Leu Gly Ser Trp Ala Leu Phe Phe Arg Arg Pro Lys Ala Ser Leu Pro 
                165                 170                 175     


Arg Val Phe Val Leu Arg Ala Leu Leu Met Val Leu Val Phe Leu Leu 
            180                 185                 190         


Val Val Ser Tyr Trp Leu Phe Tyr Gly Val Arg Ile Leu Asp Ala Arg 
        195                 200                 205             


Glu Arg Ser Tyr Gln Gly Val Val Gln Phe Ala Val Ser Leu Val Asp 
    210                 215                 220                 


Ala Leu Leu Phe Val His Tyr Leu Ala Val Val Leu Leu Glu Leu Arg 
225                 230                 235                 240 


Gln Leu Gln Pro Gln Phe Thr Leu Lys Val Val Arg Ser Thr Asp Gly 
                245                 250                 255     


Ala Ser Arg Phe Tyr Asn Val Gly His Leu Ser Ile Gln Arg Val Ala 
            260                 265                 270         


Val Trp Ile Leu Glu Lys Tyr Tyr His Asp Phe Pro Val Tyr Asn Pro 
        275                 280                 285             


Ala Leu Leu Asn Leu Pro Lys Ser Val Leu Ala Lys Lys Val Ser Gly 
    290                 295                 300                 


Phe Lys Val Tyr Ser Leu Gly Glu Glu Asn Ser Thr Asn Asn Ser Thr 
305                 310                 315                 320 


Gly Gln Ser Arg Ala Val Ile Ala Ala Ala Ala Arg Arg Arg Asp Asn 
                325                 330                 335     


Ser His Asn Glu Tyr Tyr Tyr Glu Glu Ala Glu His Glu Arg Arg Val 
            340                 345                 350         


Arg Lys Arg Arg Ala Arg Leu Val Val Ala Val Glu Glu Ala Phe Thr 
        355                 360                 365             


His Ile Lys Arg Leu Gln Glu Glu Glu Gln Lys Asn Pro Arg Glu Val 
    370                 375                 380                 


Met Asp Pro Arg Glu Ala Ala Gln Ala Ile Phe Ala Ser Met Ala Arg 
385                 390                 395                 400 


Ala Met Gln Lys Tyr Leu Arg Thr Thr Lys Gln Gln Pro Tyr His Thr 
                405                 410                 415     


Met Glu Ser Ile Leu Gln His Leu Glu Phe Cys Ile Thr His Asp Met 
            420                 425                 430         


Thr Pro Lys Ala Phe Leu Glu Arg Tyr Leu Ala Ala Gly Pro Thr Ile 
        435                 440                 445             


Gln Tyr His Lys Glu Arg Trp Leu Ala Lys Gln Trp Thr Leu Val Ser 
    450                 455                 460                 


Glu Glu Pro Val Thr Asn Gly Leu Lys Asp Gly Ile Val Phe Leu Leu 
465                 470                 475                 480 


Lys Arg Gln Asp Phe Ser Leu Val Val Ser Thr Lys Lys Val Pro Phe 
                485                 490                 495     


Phe Lys Leu Ser Glu Glu Phe Val Asp Pro Lys Ser His Lys Phe Val 
            500                 505                 510         


Met Arg Leu Gln Ser Glu Thr Ser Val 
        515                 520     


<210>  4632
<211>  661
<212>  PRT
<213>  Homo sapiens

<400>  4632

Met Asp Leu Gln Gln Ser Thr Thr Ile Thr Ser Leu Glu Lys Trp Cys 
1               5                   10                  15      


Leu Asp Glu Ser Leu Ser Gly Cys Arg Arg His Tyr Ser Val Lys Lys 
            20                  25                  30          


Lys Leu Lys Leu Ile Arg Val Leu Gly Leu Phe Met Gly Leu Val Ala 
        35                  40                  45              


Ile Ser Thr Val Ser Phe Ser Ile Ser Ala Phe Ser Glu Thr Asp Thr 
    50                  55                  60                  


Gln Ser Thr Gly Glu Ala Ser Val Val Ser Gly Pro Arg Val Ala Gln 
65                  70                  75                  80  


Gly Tyr His Gln Arg Thr Leu Leu Asp Leu Asn Asp Lys Ile Leu Asp 
                85                  90                  95      


Tyr Thr Pro Gln Pro Pro Leu Ser Lys Glu Gly Glu Ser Glu Asn Ser 
            100                 105                 110         


Thr Asp His Ala Gln Gly Asp Tyr Pro Lys Asp Ile Phe Ser Leu Glu 
        115                 120                 125             


Glu Arg Arg Lys Gly Ala Ile Ile Leu His Val Ile Gly Met Ile Tyr 
    130                 135                 140                 


Met Phe Ile Ala Leu Ala Ile Val Cys Asp Glu Phe Phe Val Pro Ser 
145                 150                 155                 160 


Leu Thr Val Ile Thr Glu Lys Leu Gly Ile Ser Asp Asp Val Ala Gly 
                165                 170                 175     


Ala Thr Phe Met Ala Ala Gly Gly Ser Ala Pro Glu Leu Phe Thr Ser 
            180                 185                 190         


Leu Ile Gly Val Phe Ile Ala His Ser Asn Val Gly Ile Gly Thr Ile 
        195                 200                 205             


Val Gly Ser Ala Val Phe Asn Ile Leu Phe Val Ile Gly Met Cys Ala 
    210                 215                 220                 


Leu Phe Ser Arg Glu Ile Leu Asn Leu Thr Trp Trp Pro Leu Phe Arg 
225                 230                 235                 240 


Asp Val Ser Phe Tyr Ile Val Asp Leu Ile Met Leu Ile Ile Phe Phe 
                245                 250                 255     


Leu Asp Asn Val Ile Met Trp Trp Glu Ser Leu Leu Leu Leu Thr Ala 
            260                 265                 270         


Tyr Phe Cys Tyr Val Val Phe Met Lys Phe Asn Val Gln Val Glu Lys 
        275                 280                 285             


Trp Val Lys Gln Met Ile Asn Arg Asn Lys Val Val Lys Val Thr Ala 
    290                 295                 300                 


Pro Glu Ala Gln Ala Lys Pro Ser Ala Ala Arg Asp Lys Asp Glu Pro 
305                 310                 315                 320 


Thr Leu Pro Ala Lys Pro Arg Leu Gln Arg Gly Gly Ser Ser Ala Ser 
                325                 330                 335     


Leu His Asn Ser Leu Met Arg Asn Ser Ile Phe Gln Leu Met Ile His 
            340                 345                 350         


Thr Leu Asp Pro Leu Ala Glu Glu Leu Gly Ser Tyr Gly Lys Leu Lys 
        355                 360                 365             


Tyr Tyr Asp Thr Met Thr Glu Glu Gly Arg Phe Arg Glu Lys Ala Ser 
    370                 375                 380                 


Ile Leu His Lys Ile Ala Lys Lys Lys Cys His Val Asp Glu Asn Glu 
385                 390                 395                 400 


Arg Gln Asn Gly Ala Ala Asn His Val Glu Lys Ile Glu Leu Pro Asn 
                405                 410                 415     


Ser Thr Ser Thr Asp Val Glu Met Thr Pro Ser Ser Asp Ala Ser Glu 
            420                 425                 430         


Pro Val Gln Asn Gly Asn Leu Ser His Asn Ile Glu Gly Ala Glu Ala 
        435                 440                 445             


Gln Thr Ala Asp Glu Glu Glu Asp Gln Pro Leu Ser Leu Ala Trp Pro 
    450                 455                 460                 


Ser Glu Thr Arg Lys Gln Val Thr Phe Leu Ile Val Phe Pro Ile Val 
465                 470                 475                 480 


Phe Pro Leu Trp Ile Thr Leu Pro Asp Val Arg Lys Pro Ser Ser Arg 
                485                 490                 495     


Lys Phe Phe Pro Ile Thr Phe Phe Gly Ser Ile Thr Trp Ile Ala Val 
            500                 505                 510         


Phe Ser Tyr Leu Met Val Trp Trp Ala His Gln Val Gly Glu Thr Ile 
        515                 520                 525             


Gly Ile Ser Glu Glu Ile Met Gly Leu Thr Ile Leu Ala Ala Gly Thr 
    530                 535                 540                 


Ser Ile Pro Asp Leu Ile Thr Ser Val Ile Val Ala Arg Lys Gly Leu 
545                 550                 555                 560 


Gly Asp Met Ala Val Ser Ser Ser Val Gly Ser Asn Ile Phe Asp Ile 
                565                 570                 575     


Thr Val Gly Leu Pro Leu Pro Trp Leu Leu Tyr Thr Val Ile His Arg 
            580                 585                 590         


Phe Gln Pro Val Ala Val Ser Ser Asn Gly Leu Phe Cys Ala Ile Val 
        595                 600                 605             


Leu Leu Phe Ile Met Leu Leu Phe Val Ile Leu Ser Ile Ala Leu Cys 
    610                 615                 620                 


Lys Trp Arg Met Asn Lys Ile Leu Gly Phe Ile Met Phe Gly Leu Tyr 
625                 630                 635                 640 


Phe Val Phe Leu Val Val Ser Val Leu Leu Glu Asp Arg Ile Leu Thr 
                645                 650                 655     


Cys Pro Val Ser Ile 
            660     


<210>  4633
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  4633

Met Glu Leu Pro Ala Val Asn Leu Lys Val Ile Leu Leu Gly His Trp 
1               5                   10                  15      


Leu Leu Thr Thr Trp Gly Cys Ile Val Phe Ser Gly Ser Tyr Ala Trp 
            20                  25                  30          


Ala Asn Phe Thr Ile Leu Ala Leu Gly Val Trp Ala Val Ala Gln Arg 
        35                  40                  45              


Asp Ser Ile Asp Ala Ile Ser Met Phe Leu Gly Gly Leu Leu Ala Thr 
    50                  55                  60                  


Ile Phe Leu Asp Ile Val His Ile Ser Ile Phe Tyr Pro Arg Val Ser 
65                  70                  75                  80  


Leu Thr Asp Thr Gly Arg Phe Gly Val Gly Met Ala Ile Leu Ser Leu 
                85                  90                  95      


Leu Leu Lys Pro Leu Ser Cys Cys Phe Val Tyr His Met Tyr Arg Glu 
            100                 105                 110         


Arg Gly Gly Glu Leu Leu Val His Thr Gly Phe Leu Gly Ser Ser Gln 
        115                 120                 125             


Asp Arg Ser Ala Tyr Gln Thr Ile Asp Ser Ala Glu Ala Pro Ala Asp 
    130                 135                 140                 


Pro Phe Ala Val Pro Glu Gly Arg Ser Gln Asp Ala Arg Gly Tyr 
145                 150                 155                 


<210>  4634
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  4634

Met Ala Arg Ile Ser Phe Ser Tyr Leu Cys Pro Ala Ser Trp Tyr Phe 
1               5                   10                  15      


Thr Val Pro Thr Val Ser Pro Phe Leu Arg Gln Arg Val Ala Phe Leu 
            20                  25                  30          


Gly Leu Phe Phe Ile Ser Cys Leu Leu Leu Leu Met Leu Ile Ile Asp 
        35                  40                  45              


Phe Arg His Trp Ser Ala Ser Leu Pro Arg Asp Arg Gln Tyr Glu Arg 
    50                  55                  60                  


Tyr Leu Ala Arg Val Gly Glu Leu Glu Ala Thr Asp Thr Glu Asp Pro 
65                  70                  75                  80  


Asn Leu Asn Tyr Gly Leu Val Val Asp Cys Gly Ser Ser Gly Ser Arg 
                85                  90                  95      


Ile Phe Val Tyr Phe Trp Pro Arg His Asn Gly Asn Pro His Asp Leu 
            100                 105                 110         


Leu Asp Ile Lys Gln Met Arg Asp Arg Asn Ser Gln Pro Val Val Lys 
        115                 120                 125             


Lys Ile Lys Pro Gly Ile Ser Ala Met Ala Asp Thr Pro Glu His Ala 
    130                 135                 140                 


Ser Asp Tyr Leu Arg Pro Leu Leu Ser Phe Ala Ala Ala His Val Pro 
145                 150                 155                 160 


Val Lys Lys His Lys Glu Thr Pro Leu Tyr Ile Leu Cys Thr Ala Gly 
                165                 170                 175     


Met Arg Leu Leu Pro Glu Arg Lys Gln Leu Ala Ile Leu Ala Asp Leu 
            180                 185                 190         


Val Lys Asp Leu Pro Leu Glu Phe Asp Phe Leu Phe Ser Gln Ser Gln 
        195                 200                 205             


Ala Glu Val Ile Ser Gly Lys Gln Glu Gly Val Tyr Ala Trp Ile Gly 
    210                 215                 220                 


Ile Asn Phe Val Leu Gly Arg Phe Asp His Glu Asp Glu Ser Asp Ala 
225                 230                 235                 240 


Glu Ala Thr Gln Glu Leu Ala Ala Gly Arg Arg Arg Thr Val Gly Ile 
                245                 250                 255     


Leu Asp Met Gly Gly Ala Ser Leu Gln Ile Ala Tyr Glu Val Pro Thr 
            260                 265                 270         


Ser Thr Ser Val Leu Pro Ala Lys Gln Glu Glu Ala Ala Lys Ile Leu 
        275                 280                 285             


Leu Ala Glu Phe Asn Leu Gly Cys Asp Val Gln His Thr Glu His Val 
    290                 295                 300                 


Tyr Arg Val Tyr Val Thr Thr Phe Leu Gly Phe Gly Gly Asn Phe Ala 
305                 310                 315                 320 


Arg Gln Arg Tyr Glu Asp Leu Val Leu Asn Glu Thr Leu Asn Lys Asn 
                325                 330                 335     


Arg Leu Leu Gly Gln Lys Thr Gly Leu Ser Pro Asp Asn Pro Phe Leu 
            340                 345                 350         


Asp Pro Cys Leu Pro Val Gly Leu Thr Asp Val Val Glu Arg Asn Ser 
        355                 360                 365             


Gln Val Leu His Val Arg Gly Arg Gly Asp Trp Val Ser Cys Gly Ala 
    370                 375                 380                 


Met Leu Ser Pro Leu Leu Ala Arg Ser Asn Thr Ser Gln Ala Ser Leu 
385                 390                 395                 400 


Asn Gly Ile Tyr Gln Ser Pro Ile Asp Phe Asn Asn Ser Glu Phe Tyr 
                405                 410                 415     


Gly Phe Ser Glu Phe Phe Tyr Cys Thr Glu Asp Val Leu Arg Ile Gly 
            420                 425                 430         


Gly Arg Tyr His Gly Pro Thr Phe Ala Lys Ala Ala Gln Asp Tyr Cys 
        435                 440                 445             


Gly Met Ala Trp Ser Val Leu Thr Gln Arg Phe Lys Asn Gly Leu Phe 
    450                 455                 460                 


Ser Ser His Ala Asp Glu His Arg Leu Lys Tyr Gln Cys Phe Lys Ser 
465                 470                 475                 480 


Ala Trp Met Tyr Gln Val Leu His Glu Gly Phe His Phe Pro Tyr Asp 
                485                 490                 495     


Tyr Pro Asn Leu Arg Thr Ala Gln Leu Val Tyr Asp Arg Glu Val Gln 
            500                 505                 510         


Trp Thr Leu Gly Ala Ile Leu Tyr Lys Thr Arg Phe Leu Pro Leu Arg 
        515                 520                 525             


Asp Leu Arg Gln Glu Gly Val Arg Gln Ala His Gly Ser Trp Phe Arg 
    530                 535                 540                 


Leu Ser Phe Val Tyr Asn His Tyr Leu Phe Phe Ala Cys Ile Leu Val 
545                 550                 555                 560 


Val Leu Leu Ala Ile Phe Leu Tyr Leu Leu Arg Leu Arg Arg Ile His 
                565                 570                 575     


His Arg Gln Thr Arg Ala Ser Ala Pro Leu Asp Leu Leu Trp Leu Glu 
            580                 585                 590         


Glu Val Val Pro Met Met Gly Val Gln Val Gly Pro 
        595                 600                 


<210>  4635
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  4635

Met Trp Asn Ser Ser Asp Ala Asn Phe Ser Cys Tyr His Glu Ser Val 
1               5                   10                  15      


Leu Gly Tyr Arg Tyr Val Ala Val Ser Trp Gly Val Val Val Ala Val 
            20                  25                  30          


Thr Gly Thr Val Gly Asn Val Leu Thr Leu Leu Ala Leu Ala Ile Gln 
        35                  40                  45              


Pro Lys Leu Arg Thr Arg Phe Asn Leu Leu Ile Ala Asn Leu Thr Leu 
    50                  55                  60                  


Ala Asp Leu Leu Tyr Cys Thr Leu Leu Gln Pro Phe Ser Val Asp Thr 
65                  70                  75                  80  


Tyr Leu His Leu His Trp Arg Thr Gly Ala Thr Phe Cys Arg Val Phe 
                85                  90                  95      


Gly Leu Leu Leu Phe Ala Ser Asn Ser Val Ser Ile Leu Thr Leu Cys 
            100                 105                 110         


Leu Ile Ala Leu Gly Arg Tyr Leu Leu Ile Ala His Pro Lys Leu Phe 
        115                 120                 125             


Pro Gln Val Phe Ser Ala Lys Gly Ile Val Leu Ala Leu Val Ser Thr 
    130                 135                 140                 


Trp Val Val Gly Val Ala Ser Phe Ala Pro Leu Trp Pro Ile Tyr Ile 
145                 150                 155                 160 


Leu Val Pro Val Val Cys Thr Cys Ser Phe Asp Arg Ile Arg Gly Arg 
                165                 170                 175     


Pro Tyr Thr Thr Ile Leu Met Gly Ile Tyr Phe Val Leu Gly Leu Ser 
            180                 185                 190         


Ser Val Gly Ile Phe Tyr Cys Leu Ile His Arg Gln Val Lys Arg Ala 
        195                 200                 205             


Ala Gln Ala Leu Asp Gln Tyr Lys Leu Arg Gln Ala Ser Ile His Ser 
    210                 215                 220                 


Asn His Val Ala Arg Thr Asp Glu Ala Met Pro Gly Arg Phe Gln Glu 
225                 230                 235                 240 


Leu Asp Ser Arg Leu Ala Ser Gly Gly Pro Ser Glu Gly Ile Ser Ser 
                245                 250                 255     


Glu Pro Val Ser Ala Ala Thr Thr Gln Thr Leu Glu Gly Asp Ser Ser 
            260                 265                 270         


Glu Val Gly Asp Gln Ile Asn Ser Lys Arg Ala Lys Gln Met Ala Glu 
        275                 280                 285             


Lys Ser Pro Pro Glu Ala Ser Ala Lys Ala Gln Pro Ile Lys Gly Ala 
    290                 295                 300                 


Arg Arg Ala Pro Asp Ser Ser Ser Glu Phe Gly Lys Val Thr Arg Met 
305                 310                 315                 320 


Cys Phe Ala Val Phe Leu Cys Phe Ala Leu Ser Tyr Ile Pro Phe Leu 
                325                 330                 335     


Leu Leu Asn Ile Leu Asp Ala Arg Val Gln Ala Pro Arg Val Val His 
            340                 345                 350         


Met Leu Ala Ala Asn Leu Thr Trp Leu Asn Gly Cys Ile Asn Pro Val 
        355                 360                 365             


Leu Tyr Ala Ala Met Asn Arg Gln Phe Arg Gln Ala Tyr Gly Ser Ile 
    370                 375                 380                 


Leu Lys Arg Gly Pro Arg Ser Phe His Arg Leu His 
385                 390                 395     


<210>  4636
<211>  1549
<212>  PRT
<213>  Homo sapiens

<400>  4636

Met Ser Leu Ser Phe Cys Gly Asn Asn Ile Ser Ser Tyr Asn Ile Asn 
1               5                   10                  15      


Asp Gly Val Leu Gln Asn Ser Cys Phe Val Asp Ala Leu Asn Leu Val 
            20                  25                  30          


Pro His Val Phe Leu Leu Phe Ile Thr Phe Pro Ile Leu Phe Ile Gly 
        35                  40                  45              


Trp Gly Ser Gln Ser Ser Lys Val Gln Ile His His Asn Thr Trp Leu 
    50                  55                  60                  


His Phe Pro Gly His Asn Leu Arg Trp Ile Leu Thr Phe Ala Leu Leu 
65                  70                  75                  80  


Phe Val His Val Cys Glu Ile Ala Glu Gly Ile Val Ser Asp Ser Arg 
                85                  90                  95      


Arg Glu Ser Arg His Leu His Leu Phe Met Pro Ala Val Met Gly Phe 
            100                 105                 110         


Val Ala Thr Thr Thr Ser Ile Val Tyr Tyr His Asn Ile Glu Thr Ser 
        115                 120                 125             


Asn Phe Pro Lys Leu Leu Leu Ala Leu Phe Leu Tyr Trp Val Met Ala 
    130                 135                 140                 


Phe Ile Thr Lys Thr Ile Lys Leu Val Lys Tyr Cys Gln Ser Gly Leu 
145                 150                 155                 160 


Asp Ile Ser Asn Leu Arg Phe Cys Ile Thr Gly Met Met Val Ile Leu 
                165                 170                 175     


Asn Gly Leu Leu Met Ala Val Glu Ile Asn Val Ile Arg Val Arg Arg 
            180                 185                 190         


Tyr Val Phe Phe Met Asn Pro Gln Lys Val Lys Pro Pro Glu Asp Leu 
        195                 200                 205             


Gln Asp Leu Gly Val Arg Phe Leu Gln Pro Phe Val Asn Leu Leu Ser 
    210                 215                 220                 


Lys Ala Thr Tyr Trp Trp Met Asn Thr Leu Ile Ile Ser Ala His Lys 
225                 230                 235                 240 


Lys Pro Ile Asp Leu Lys Ala Ile Gly Lys Leu Pro Ile Ala Met Arg 
                245                 250                 255     


Ala Val Thr Asn Tyr Val Cys Leu Lys Asp Ala Tyr Glu Glu Gln Lys 
            260                 265                 270         


Lys Lys Val Ala Asp His Pro Asn Arg Thr Pro Ser Ile Trp Leu Ala 
        275                 280                 285             


Met Tyr Arg Ala Phe Gly Arg Pro Ile Leu Leu Ser Ser Thr Phe Arg 
    290                 295                 300                 


Tyr Leu Ala Asp Leu Leu Gly Phe Ala Gly Pro Leu Cys Ile Ser Gly 
305                 310                 315                 320 


Ile Val Gln Arg Val Asn Glu Thr Gln Asn Gly Thr Asn Asn Thr Thr 
                325                 330                 335     


Gly Ile Ser Glu Thr Leu Ser Ser Lys Glu Phe Leu Glu Asn Ala Tyr 
            340                 345                 350         


Val Leu Ala Val Leu Leu Phe Leu Ala Leu Ile Leu Gln Arg Thr Phe 
        355                 360                 365             


Leu Gln Ala Ser Tyr Tyr Val Thr Ile Glu Thr Gly Ile Asn Leu Arg 
    370                 375                 380                 


Gly Ala Leu Leu Ala Met Ile Tyr Asn Lys Ile Leu Arg Leu Ser Thr 
385                 390                 395                 400 


Ser Asn Leu Ser Met Gly Glu Met Thr Leu Gly Gln Ile Asn Asn Leu 
                405                 410                 415     


Val Ala Ile Glu Thr Asn Gln Leu Met Trp Phe Leu Phe Leu Cys Pro 
            420                 425                 430         


Asn Leu Trp Ala Met Pro Val Gln Ile Ile Met Gly Val Ile Leu Leu 
        435                 440                 445             


Tyr Asn Leu Leu Gly Ser Ser Ala Leu Val Gly Ala Ala Val Ile Val 
    450                 455                 460                 


Leu Leu Ala Pro Ile Gln Tyr Phe Ile Ala Thr Lys Leu Ala Glu Ala 
465                 470                 475                 480 


Gln Lys Ser Thr Leu Asp Tyr Ser Thr Glu Arg Leu Lys Lys Thr Asn 
                485                 490                 495     


Glu Ile Leu Lys Gly Ile Lys Leu Leu Lys Leu Tyr Ala Trp Glu His 
            500                 505                 510         


Ile Phe Cys Lys Ser Val Glu Glu Thr Arg Met Lys Glu Leu Ser Ser 
        515                 520                 525             


Leu Lys Thr Phe Ala Leu Tyr Thr Ser Leu Ser Ile Phe Met Asn Ala 
    530                 535                 540                 


Ala Ile Pro Ile Ala Ala Val Leu Ala Thr Phe Val Thr His Ala Tyr 
545                 550                 555                 560 


Ala Ser Gly Asn Asn Leu Lys Pro Ala Glu Ala Phe Ala Ser Leu Ser 
                565                 570                 575     


Leu Phe His Ile Leu Val Thr Pro Leu Phe Leu Leu Ser Thr Val Val 
            580                 585                 590         


Arg Phe Ala Val Lys Ala Ile Ile Ser Val Gln Lys Leu Asn Glu Phe 
        595                 600                 605             


Leu Leu Ser Asp Glu Ile Gly Asp Asp Ser Trp Arg Thr Gly Glu Ser 
    610                 615                 620                 


Ser Leu Pro Phe Glu Ser Cys Lys Lys His Thr Gly Val Gln Pro Lys 
625                 630                 635                 640 


Thr Ile Asn Arg Lys Gln Pro Gly Arg Tyr His Leu Asp Ser Tyr Glu 
                645                 650                 655     


Gln Ser Thr Arg Arg Leu Arg Pro Ala Glu Thr Glu Asp Ile Ala Ile 
            660                 665                 670         


Lys Val Thr Asn Gly Tyr Phe Ser Trp Gly Ser Gly Leu Ala Thr Leu 
        675                 680                 685             


Ser Asn Ile Asp Ile Arg Ile Pro Thr Gly Gln Leu Thr Met Ile Val 
    690                 695                 700                 


Gly Gln Val Gly Cys Gly Lys Ser Ser Leu Leu Leu Ala Ile Leu Gly 
705                 710                 715                 720 


Glu Met Gln Thr Leu Glu Gly Lys Val His Trp Ser Asn Val Asn Glu 
                725                 730                 735     


Ser Glu Pro Ser Phe Glu Ala Thr Arg Ser Arg Asn Arg Tyr Ser Val 
            740                 745                 750         


Ala Tyr Ala Ala Gln Lys Pro Trp Leu Leu Asn Ala Thr Val Glu Glu 
        755                 760                 765             


Asn Ile Thr Phe Gly Ser Pro Phe Asn Lys Gln Arg Tyr Lys Ala Val 
    770                 775                 780                 


Thr Asp Ala Cys Ser Leu Gln Pro Asp Ile Asp Leu Leu Pro Phe Gly 
785                 790                 795                 800 


Asp Gln Thr Glu Ile Gly Glu Arg Gly Ile Asn Leu Ser Gly Gly Gln 
                805                 810                 815     


Arg Gln Arg Ile Cys Val Ala Arg Ala Leu Tyr Gln Asn Thr Asn Ile 
            820                 825                 830         


Val Phe Leu Asp Asp Pro Phe Ser Ala Leu Asp Ile His Leu Ser Asp 
        835                 840                 845             


His Leu Met Gln Glu Gly Ile Leu Lys Phe Leu Gln Asp Asp Lys Arg 
    850                 855                 860                 


Thr Leu Val Leu Val Thr His Lys Leu Gln Tyr Leu Thr His Ala Asp 
865                 870                 875                 880 


Trp Ile Ile Ala Met Lys Asp Gly Ser Val Leu Arg Glu Gly Thr Leu 
                885                 890                 895     


Lys Asp Ile Gln Thr Lys Asp Val Glu Leu Tyr Glu His Trp Lys Thr 
            900                 905                 910         


Leu Met Asn Arg Gln Asp Gln Glu Leu Glu Lys Asp Met Glu Ala Asp 
        915                 920                 925             


Gln Thr Thr Leu Glu Arg Lys Thr Leu Arg Arg Ala Met Tyr Ser Arg 
    930                 935                 940                 


Glu Ala Lys Ala Gln Met Glu Asp Glu Asp Glu Glu Glu Glu Glu Glu 
945                 950                 955                 960 


Glu Asp Glu Asp Asp Asn Met Ser Thr Val Met Arg Leu Arg Thr Lys 
                965                 970                 975     


Met Pro Trp Lys Thr Cys Trp Arg Tyr Leu Thr Ser Gly Gly Phe Phe 
            980                 985                 990         


Leu Leu Ile Leu Met Ile Phe Ser  Lys Leu Leu Lys His  Ser Val Ile 
        995                 1000                 1005             


Val Ala  Ile Asp Tyr Trp Leu  Ala Thr Trp Thr Ser  Glu Tyr Ser 
    1010                 1015                 1020             


Ile Asn  Asn Thr Gly Lys Ala  Asp Gln Thr Tyr Tyr  Val Ala Gly 
    1025                 1030                 1035             


Phe Ser  Ile Leu Cys Gly Ala  Gly Ile Phe Leu Cys  Leu Val Thr 
    1040                 1045                 1050             


Ser Leu  Thr Val Glu Trp Met  Gly Leu Thr Ala Ala  Lys Asn Leu 
    1055                 1060                 1065             


His His  Asn Leu Leu Asn Lys  Ile Ile Leu Gly Pro  Ile Arg Phe 
    1070                 1075                 1080             


Phe Asp  Thr Thr Pro Leu Gly  Leu Ile Leu Asn Arg  Phe Ser Ala 
    1085                 1090                 1095             


Asp Thr  Asn Ile Ile Asp Gln  His Ile Pro Pro Thr  Leu Glu Ser 
    1100                 1105                 1110             


Leu Thr  Arg Ser Thr Leu Leu  Cys Leu Ser Ala Ile  Gly Met Ile 
    1115                 1120                 1125             


Ser Tyr  Ala Thr Pro Val Phe  Leu Val Ala Leu Leu  Pro Leu Gly 
    1130                 1135                 1140             


Val Ala  Phe Tyr Phe Ile Gln  Lys Tyr Phe Arg Val  Ala Ser Lys 
    1145                 1150                 1155             


Asp Leu  Gln Glu Leu Asp Asp  Ser Thr Gln Leu Pro  Leu Leu Cys 
    1160                 1165                 1170             


His Phe  Ser Glu Thr Ala Glu  Gly Leu Thr Thr Ile  Arg Ala Phe 
    1175                 1180                 1185             


Arg His  Glu Thr Arg Phe Lys  Gln Arg Met Leu Glu  Leu Thr Asp 
    1190                 1195                 1200             


Thr Asn  Asn Ile Ala Tyr Leu  Phe Leu Ser Ala Ala  Asn Arg Trp 
    1205                 1210                 1215             


Leu Glu  Val Arg Thr Asp Tyr  Leu Gly Ala Cys Ile  Val Leu Thr 
    1220                 1225                 1230             


Ala Ser  Ile Ala Ser Ile Ser  Gly Ser Ser Asn Ser  Gly Leu Val 
    1235                 1240                 1245             


Gly Leu  Gly Leu Leu Tyr Ala  Leu Thr Ile Thr Asn  Tyr Leu Asn 
    1250                 1255                 1260             


Trp Val  Val Arg Asn Leu Ala  Asp Leu Glu Val Gln  Met Gly Ala 
    1265                 1270                 1275             


Val Lys  Lys Val Asn Ser Phe  Leu Thr Met Glu Ser  Glu Asn Tyr 
    1280                 1285                 1290             


Glu Gly  Thr Met Asp Pro Ser  Gln Val Pro Glu His  Trp Pro Gln 
    1295                 1300                 1305             


Glu Gly  Glu Ile Lys Ile His  Asp Leu Cys Val Arg  Tyr Glu Asn 
    1310                 1315                 1320             


Asn Leu  Lys Pro Val Leu Lys  His Val Lys Ala Tyr  Ile Lys Pro 
    1325                 1330                 1335             


Gly Gln  Lys Val Gly Ile Cys  Gly Arg Thr Gly Ser  Gly Lys Ser 
    1340                 1345                 1350             


Ser Leu  Ser Leu Ala Phe Phe  Arg Met Val Asp Ile  Phe Asp Gly 
    1355                 1360                 1365             


Lys Ile  Val Ile Asp Gly Ile  Asp Ile Ser Lys Leu  Pro Leu His 
    1370                 1375                 1380             


Thr Leu  Arg Ser Arg Leu Ser  Ile Ile Leu Gln Asp  Pro Ile Leu 
    1385                 1390                 1395             


Phe Ser  Gly Ser Ile Arg Phe  Asn Leu Asp Pro Glu  Cys Lys Cys 
    1400                 1405                 1410             


Thr Asp  Asp Arg Leu Trp Glu  Ala Leu Glu Ile Ala  Gln Leu Lys 
    1415                 1420                 1425             


Asn Met  Val Lys Ser Leu Pro  Gly Gly Leu Asp Ala  Val Val Thr 
    1430                 1435                 1440             


Glu Gly  Gly Glu Asn Phe Ser  Val Gly Gln Arg Gln  Leu Phe Cys 
    1445                 1450                 1455             


Leu Ala  Arg Ala Phe Val Arg  Lys Ser Ser Ile Leu  Ile Met Asp 
    1460                 1465                 1470             


Glu Ala  Thr Ala Ser Ile Asp  Met Ala Thr Glu Asn  Ile Leu Gln 
    1475                 1480                 1485             


Lys Val  Val Met Thr Ala Phe  Ala Asp Arg Thr Val  Val Thr Ile 
    1490                 1495                 1500             


Ala His  Arg Val Ser Ser Ile  Met Asp Ala Gly Leu  Val Leu Val 
    1505                 1510                 1515             


Phe Ser  Glu Gly Ile Leu Val  Glu Cys Asp Thr Val  Pro Asn Leu 
    1520                 1525                 1530             


Leu Ala  His Lys Asn Gly Leu  Phe Ser Thr Leu Val  Met Thr Asn 
    1535                 1540                 1545             


Lys 
    


<210>  4637
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  4637

Met Ala Ser Asp Pro Ile Phe Thr Leu Ala Pro Pro Leu His Cys His 
1               5                   10                  15      


Tyr Gly Ala Phe Pro Pro Asn Ala Ser Gly Trp Glu Gln Pro Pro Asn 
            20                  25                  30          


Ala Ser Gly Val Ser Val Ala Ser Ala Ala Leu Ala Ala Ser Ala Ala 
        35                  40                  45              


Ser Arg Val Ala Thr Ser Thr Asp Pro Ser Cys Ser Gly Phe Ala Pro 
    50                  55                  60                  


Pro Asp Phe Asn His Cys Leu Lys Asp Trp Asp Tyr Asn Gly Leu Pro 
65                  70                  75                  80  


Val Leu Thr Thr Asn Ala Ile Gly Gln Trp Asp Leu Val Cys Asp Leu 
                85                  90                  95      


Gly Trp Gln Val Ile Leu Glu Gln Ile Leu Phe Ile Leu Gly Phe Ala 
            100                 105                 110         


Ser Gly Tyr Leu Phe Leu Gly Tyr Pro Ala Asp Arg Phe Gly Arg Arg 
        115                 120                 125             


Gly Ile Val Leu Leu Thr Leu Gly Leu Val Gly Pro Cys Gly Val Gly 
    130                 135                 140                 


Gly Ala Ala Ala Gly Ser Ser Thr Gly Val Met Ala Leu Arg Phe Leu 
145                 150                 155                 160 


Leu Gly Phe Leu Leu Ala Gly Val Asp Leu Gly Val Tyr Leu Met Arg 
                165                 170                 175     


Leu Glu Leu Cys Asp Pro Thr Gln Arg Leu Arg Val Ala Leu Ala Gly 
            180                 185                 190         


Glu Leu Val Gly Val Gly Gly His Phe Leu Phe Leu Gly Leu Ala Leu 
        195                 200                 205             


Val Ser Lys Asp Trp Arg Phe Leu Gln Arg Met Ile Thr Ala Pro Cys 
    210                 215                 220                 


Ile Leu Phe Leu Phe Tyr Gly Trp Pro Gly Leu Phe Leu Glu Ser Ala 
225                 230                 235                 240 


Arg Trp Leu Ile Val Lys Arg Gln Ile Glu Glu Ala Gln Ser Val Leu 
                245                 250                 255     


Arg Ile Leu Ala Glu Arg Asn Arg Pro His Gly Gln Met Leu Gly Glu 
            260                 265                 270         


Glu Ala Gln Glu Ala Leu Gln Asp Leu Glu Asn Thr Cys Pro Leu Pro 
        275                 280                 285             


Ala Thr Ser Ser Phe Ser Phe Ala Ser Leu Leu Asn Tyr Arg Asn Ile 
    290                 295                 300                 


Trp Lys Asn Leu Leu Ile Leu Gly Phe Thr Asn Phe Ile Ala His Ala 
305                 310                 315                 320 


Ile Arg His Cys Tyr Gln Pro Val Gly Gly Gly Gly Ser Pro Ser Asp 
                325                 330                 335     


Phe Tyr Leu Cys Ser Leu Leu Ala Ser Gly Thr Ala Ala Leu Ala Cys 
            340                 345                 350         


Val Phe Leu Gly Val Thr Val Asp Arg Phe Gly Arg Arg Gly Ile Leu 
        355                 360                 365             


Leu Leu Ser Met Thr Leu Thr Gly Ile Ala Ser Leu Val Leu Leu Gly 
    370                 375                 380                 


Leu Trp Asp Cys Glu His Pro Ile Phe Pro Thr Val Trp Ala Gln Gln 
385                 390                 395                 400 


Gly Asn Pro Asn Arg Asp Leu Asn Glu Ala Ala Ile Thr Thr Phe Ser 
                405                 410                 415     


Val Leu Gly Leu Phe Ser Ser Gln Ala Ala Ala Ile Leu Ser Thr Leu 
            420                 425                 430         


Leu Ala Ala Glu Val Ile Pro Thr Thr Val Arg Gly Arg Gly Leu Gly 
        435                 440                 445             


Leu Ile Met Ala Leu Gly Ala Leu Gly Gly Leu Ser Gly Pro Ala Gln 
    450                 455                 460                 


Arg Leu His Met Gly His Gly Ala Phe Leu Gln His Val Val Leu Ala 
465                 470                 475                 480 


Ala Cys Ala Leu Leu Cys Ile Leu Ser Ile Met Leu Leu Pro Glu Thr 
                485                 490                 495     


Lys Arg Lys Leu Leu Pro Glu Val Leu Arg Asp Gly Glu Leu Cys Arg 
            500                 505                 510         


Arg Pro Ser Leu Leu Arg Gln Pro Pro Pro Thr Arg Cys Asp His Val 
        515                 520                 525             


Pro Leu Leu Ala Thr Pro Asn Pro Ala Leu 
    530                 535             


<210>  4638
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  4638

Met Phe Pro Arg Glu Lys Thr Trp Asn Ile Ser Phe Ala Gly Cys Gly 
1               5                   10                  15      


Phe Leu Gly Val Tyr Tyr Val Gly Val Ala Ser Cys Leu Arg Glu His 
            20                  25                  30          


Ala Pro Phe Leu Val Ala Asn Ala Thr His Ile Tyr Gly Ala Ser Ala 
        35                  40                  45              


Gly Ala Leu Thr Ala Thr Ala Leu Val Thr Gly Val Cys Leu Gly Glu 
    50                  55                  60                  


Ala Gly Ala Lys Phe Ile Glu Val Ser Lys Glu Ala Arg Lys Arg Phe 
65                  70                  75                  80  


Leu Gly Pro Leu His Pro Ser Phe Asn Leu Val Lys Ile Ile Arg Ser 
                85                  90                  95      


Phe Leu Leu Lys Val Leu Pro Ala Asp Ser His Glu His Ala Ser Gly 
            100                 105                 110         


Arg Leu Gly Ile Ser Leu Thr Arg Val Ser Asp Gly Glu Asn Val Ile 
        115                 120                 125             


Ile Ser His Phe Asn Ser Lys Asp Glu Leu Ile Gln Ala Asn Val Cys 
    130                 135                 140                 


Ser Gly Phe Ile Pro Val Tyr Cys Gly Leu Ile Pro Pro Ser Leu Gln 
145                 150                 155                 160 


Gly Val Arg Tyr Val Asp Gly Gly Ile Ser Asp Asn Leu Pro Leu Tyr 
                165                 170                 175     


Glu Leu Lys Asn Thr Ile Thr Val Ser Pro Phe Ser Gly Glu Ser Asp 
            180                 185                 190         


Ile Cys Pro Gln Asp Ser Ser Thr Asn Ile His Glu Leu Arg Val Thr 
        195                 200                 205             


Asn Thr Ser Ile Gln Phe Asn Leu Arg Asn Leu Tyr Arg Leu Ser Lys 
    210                 215                 220                 


Ala Leu Phe Pro Pro Glu Pro Leu Val Leu Arg Glu Met Cys Lys Gln 
225                 230                 235                 240 


Gly Tyr Arg Asp Gly Leu Arg Phe Leu Gln Arg Asn Gly Leu Leu Asn 
                245                 250                 255     


Arg Pro Asn Pro Leu Leu Ala Leu Pro Pro Ala Arg Pro His Gly Pro 
            260                 265                 270         


Glu Asp Lys Asp Gln Ala Val Glu Ser Ala Gln Ala Glu Asp Tyr Ser 
        275                 280                 285             


Gln Leu Pro Gly Glu Asp His Ile Leu Glu His Leu Pro Ala Arg Leu 
    290                 295                 300                 


Asn Glu Ala Leu Leu Glu Ala Cys Val Glu Pro Thr Asp Leu Leu Thr 
305                 310                 315                 320 


Thr Leu Ser Asn Met Leu Pro Val Arg Leu Ala Thr Ala Met Met Val 
                325                 330                 335     


Pro Tyr Thr Leu Pro Leu Glu Ser Ala Leu Ser Phe Thr Ile Arg Leu 
            340                 345                 350         


Leu Glu Trp Leu Pro Asp Val Pro Glu Asp Ile Arg Trp Met Lys Glu 
        355                 360                 365             


Gln Thr Gly Ser Ile Cys Gln Tyr Leu Val Met Arg Ala Lys Arg Lys 
    370                 375                 380                 


Leu Gly Arg His Leu Pro Ser Arg Leu Pro Glu Gln Val Glu Leu Arg 
385                 390                 395                 400 


Arg Val Gln Ser Leu Pro Ser Val Pro Leu Ser Cys Ala Ala Tyr Arg 
                405                 410                 415     


Glu Ala Leu Pro Gly Trp Met Arg Asn Asn Leu Ser Leu Gly Asp Ala 
            420                 425                 430         


Leu Ala Lys Trp Glu Glu Cys Gln Arg Gln Leu Leu Leu Gly Leu Phe 
        435                 440                 445             


Cys Thr Asn Val Ala Phe Pro Pro Glu Ala Leu Arg Met Arg Ala Pro 
    450                 455                 460                 


Ala Asp Pro Ala Pro Ala Pro Ala Asp Pro Ala Ser Pro Gln His Gln 
465                 470                 475                 480 


Leu Ala Gly Pro Ala Pro Leu Leu Ser Thr Pro Ala Pro Glu Ala Arg 
                485                 490                 495     


Pro Val Ile Gly Ala Leu Gly Leu 
            500                 


<210>  4639
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  4639

Met Glu Arg Lys Phe Met Ser Leu Gln Pro Ser Ile Ser Val Ser Glu 
1               5                   10                  15      


Met Glu Pro Asn Gly Thr Phe Ser Asn Asn Asn Ser Arg Asn Cys Thr 
            20                  25                  30          


Ile Glu Asn Phe Lys Arg Glu Phe Phe Pro Ile Val Tyr Leu Ile Ile 
        35                  40                  45              


Phe Phe Trp Gly Val Leu Gly Asn Gly Leu Ser Ile Tyr Val Phe Leu 
    50                  55                  60                  


Gln Pro Tyr Lys Lys Ser Thr Ser Val Asn Val Phe Met Leu Asn Leu 
65                  70                  75                  80  


Ala Ile Ser Asp Leu Leu Phe Ile Ser Thr Leu Pro Phe Arg Ala Asp 
                85                  90                  95      


Tyr Tyr Leu Arg Gly Ser Asn Trp Ile Phe Gly Asp Leu Ala Cys Arg 
            100                 105                 110         


Ile Met Ser Tyr Ser Leu Tyr Val Asn Met Tyr Ser Ser Ile Tyr Phe 
        115                 120                 125             


Leu Thr Val Leu Ser Val Val Arg Phe Leu Ala Met Val His Pro Phe 
    130                 135                 140                 


Arg Leu Leu His Val Thr Ser Ile Arg Ser Ala Trp Ile Leu Cys Gly 
145                 150                 155                 160 


Ile Ile Trp Ile Leu Ile Met Ala Ser Ser Ile Met Leu Leu Asp Ser 
                165                 170                 175     


Gly Ser Glu Gln Asn Gly Ser Val Thr Ser Cys Leu Glu Leu Asn Leu 
            180                 185                 190         


Tyr Lys Ile Ala Lys Leu Gln Thr Met Asn Tyr Ile Ala Leu Val Val 
        195                 200                 205             


Gly Cys Leu Leu Pro Phe Phe Thr Leu Ser Ile Cys Tyr Leu Leu Ile 
    210                 215                 220                 


Ile Arg Val Leu Leu Lys Val Glu Val Pro Glu Ser Gly Leu Arg Val 
225                 230                 235                 240 


Ser His Arg Lys Ala Leu Thr Thr Ile Ile Ile Thr Leu Ile Ile Phe 
                245                 250                 255     


Phe Leu Cys Phe Leu Pro Tyr His Thr Leu Arg Thr Val His Leu Thr 
            260                 265                 270         


Thr Trp Lys Val Gly Leu Cys Lys Asp Arg Leu His Lys Ala Leu Val 
        275                 280                 285             


Ile Thr Leu Ala Leu Ala Ala Ala Asn Ala Cys Phe Asn Pro Leu Leu 
    290                 295                 300                 


Tyr Tyr Phe Ala Gly Glu Asn Phe Lys Asp Arg Leu Lys Ser Ala Leu 
305                 310                 315                 320 


Arg Lys Gly His Pro Gln Lys Ala Lys Thr Lys Cys Val Phe Pro Val 
                325                 330                 335     


Ser Val Trp Leu Arg Lys Glu Thr Arg Val 
            340                 345     


<210>  4640
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  4640

Met Ala Pro Ser His Leu Ser Val Arg Glu Met Arg Glu Asp Glu Lys 
1               5                   10                  15      


Pro Leu Val Leu Glu Met Leu Lys Ala Gly Val Lys Asp Thr Glu Asn 
            20                  25                  30          


Arg Val Ala Leu His Ala Leu Thr Arg Pro Pro Ala Leu Leu Leu Leu 
        35                  40                  45              


Ala Ala Ala Ser Ser Gly Leu Arg Phe Val Leu Ala Ser Phe Ala Leu 
    50                  55                  60                  


Ala Leu Leu Leu Pro Val Phe Leu Ala Val Ala Ala Val Lys Leu Gly 
65                  70                  75                  80  


Leu Arg Ala Arg Trp Gly Ser Leu Pro Pro Pro Gly Gly Leu Gly Gly 
                85                  90                  95      


Pro Trp Val Ala Val Arg Gly Ser Gly Asp Val Cys Gly Val Leu Ala 
            100                 105                 110         


Leu Ala Pro Gly Thr Asn Ala Gly Asp Gly Ala Arg Val Thr Arg Leu 
        115                 120                 125             


Ser Val Ser Arg Trp His Arg Arg Arg Gly Val Gly Arg Arg Leu Leu 
    130                 135                 140                 


Ala Phe Ala Glu Ala Arg Ala Arg Ala Trp Ala Gly Gly Met Gly Glu 
145                 150                 155                 160 


Pro Arg Ala Arg Leu Val Val Pro Val Ala Val Ala Ala Trp Gly Val 
                165                 170                 175     


Gly Gly Met Leu Glu Gly Cys Gly Tyr Gln Ala Glu Gly Gly Trp Gly 
            180                 185                 190         


Cys Leu Gly Tyr Thr Leu Val Arg Glu Phe Ser Lys Asp Leu 
        195                 200                 205     


<210>  4641
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  4641

Met Leu Met Arg Lys Val Pro Gly Phe Val Pro Ala Ser Pro Trp Gly 
1               5                   10                  15      


Leu Arg Leu Pro Gln Lys Phe Leu Phe Leu Leu Phe Leu Ser Gly Leu 
            20                  25                  30          


Val Thr Leu Cys Phe Gly Ala Leu Phe Leu Leu Pro His Ser Ser Arg 
        35                  40                  45              


Leu Lys Arg Leu Phe Leu Ala Pro Arg Thr Gln Gln Pro Gly Leu Glu 
    50                  55                  60                  


Val Val Ala Glu Ile Ala Gly His Ala Pro Ala Arg Glu Gln Glu Pro 
65                  70                  75                  80  


Pro Pro Asn Pro Ala Pro Ala Ala Pro Ala Pro Gly Glu Asp Asp Pro 
                85                  90                  95      


Ser Ser Trp Ala Ser Pro Arg Arg Arg Lys Gly Gly Leu Arg Arg Thr 
            100                 105                 110         


Arg Pro Thr Gly Pro Arg Glu Glu Ala Thr Ala Ala Arg Gly Asn Ser 
        115                 120                 125             


Ile Pro Ala Ser Arg Pro Gly Asp Glu Gly Val Pro Phe Arg Phe Asp 
    130                 135                 140                 


Phe Asn Ala Phe Arg Ser Arg Leu Arg His Pro Val Leu Gly Thr Arg 
145                 150                 155                 160 


Ala Asp Glu Ser Gln Glu Pro Gln Ser Gln Val Arg Ala Gln Arg Glu 
                165                 170                 175     


Lys Ile Lys Glu Met Met Gln Phe Ala Trp Gln Ser Tyr Lys Arg Tyr 
            180                 185                 190         


Ala Met Gly Lys Asn Glu Leu Arg Pro Leu Thr Lys Asp Gly Tyr Glu 
        195                 200                 205             


Gly Asn Met Phe Gly Gly Leu Ser Gly Ala Thr Val Ile Asp Ser Leu 
    210                 215                 220                 


Asp Thr Leu Tyr Leu Met Glu Leu Lys Glu Glu Phe Gln Glu Ala Lys 
225                 230                 235                 240 


Ala Trp Val Gly Glu Ser Phe His Leu Asn Val Ser Gly Glu Ala Ser 
                245                 250                 255     


Leu Phe Glu Val Asn Ile Arg Tyr Ile Gly Gly Leu Leu Ser Ala Phe 
            260                 265                 270         


Tyr Leu Thr Gly Glu Glu Val Phe Arg Ile Lys Ala Ile Arg Leu Gly 
        275                 280                 285             


Glu Lys Leu Leu Pro Ala Phe Asn Thr Pro Thr Gly Ile Pro Lys Gly 
    290                 295                 300                 


Val Val Ser Phe Lys Ser Gly Asn Trp Gly Trp Ala Thr Ala Gly Ser 
305                 310                 315                 320 


Ser Ser Ile Leu Ala Glu Phe Gly Ser Leu His Leu Glu Phe Leu His 
                325                 330                 335     


Leu Thr Glu Leu Ser Gly Asn Gln Val Phe Ala Glu Lys Val Arg Asn 
            340                 345                 350         


Ile Arg Lys Val Leu Arg Lys Ile Glu Lys Pro Phe Gly Leu Tyr Pro 
        355                 360                 365             


Asn Phe Leu Ser Pro Val Ser Gly Asn Trp Val Gln His His Val Ser 
    370                 375                 380                 


Val Gly Gly Leu Gly Asp Ser Phe Tyr Glu Tyr Leu Ile Lys Ser Trp 
385                 390                 395                 400 


Leu Met Ser Gly Lys Thr Asp Met Glu Ala Lys Asn Met Tyr Tyr Glu 
                405                 410                 415     


Ala Leu Glu Ala Ile Glu Thr Tyr Leu Leu Asn Val Ser Pro Gly Gly 
            420                 425                 430         


Leu Thr Tyr Ile Ala Glu Trp Arg Gly Gly Ile Leu Asp His Lys Met 
        435                 440                 445             


Gly His Leu Ala Cys Phe Ser Gly Gly Met Ile Ala Leu Gly Ala Glu 
    450                 455                 460                 


Asp Ala Lys Glu Glu Lys Arg Ala His Tyr Arg Glu Leu Ala Ala Gln 
465                 470                 475                 480 


Ile Thr Lys Thr Cys His Glu Ser Tyr Ala Arg Ser Asp Thr Lys Leu 
                485                 490                 495     


Gly Pro Glu Ala Phe Trp Phe Asn Ser Gly Arg Glu Ala Val Ala Thr 
            500                 505                 510         


Gln Leu Ser Glu Ser Tyr Tyr Ile Leu Arg Pro Glu Val Val Glu Ser 
        515                 520                 525             


Tyr Met Tyr Leu Trp Arg Gln Thr His Asn Pro Ile Tyr Arg Glu Trp 
    530                 535                 540                 


Gly Trp Glu Val Val Leu Ala Leu Glu Lys Tyr Cys Arg Thr Glu Ala 
545                 550                 555                 560 


Gly Phe Ser Gly Ile Gln Asp Val Tyr Ser Ser Thr Pro Asn His Asp 
                565                 570                 575     


Asn Lys Gln Gln Ser Phe Phe Leu Ala Glu Thr Leu Lys Tyr Leu Tyr 
            580                 585                 590         


Leu Leu Phe Ser Glu Asp Asp Leu Leu Ser Leu Glu Asp Trp Val Phe 
        595                 600                 605             


Asn Thr Glu Ala His Pro Leu Pro Val Asn His Ser Asp Ser Ser Gly 
    610                 615                 620                 


Arg Ala Trp Gly Arg His 
625                 630 


<210>  4642
<211>  5675
<212>  PRT
<213>  Homo sapiens

<400>  4642

Met Ile Ala Ala Ala Phe Leu Val Leu Leu Arg Pro Tyr Ser Ile Gln 
1               5                   10                  15      


Cys Ala Leu Phe Leu Leu Leu Leu Leu Leu Gly Thr Ile Ala Thr Ile 
            20                  25                  30          


Val Phe Phe Cys Cys Trp His Arg Lys Leu Gln Lys Gly Arg His Pro 
        35                  40                  45              


Met Lys Ser Val Phe Ser Gly Arg Ser Arg Ser Arg Asp Ala Val Leu 
    50                  55                  60                  


Arg Ser His His Phe Arg Ser Glu Gly Phe Arg Ala Ser Pro Arg His 
65                  70                  75                  80  


Leu Arg Arg Arg Val Ala Ala Ala Ala Ala Ala Arg Leu Glu Glu Val 
                85                  90                  95      


Lys Pro Val Val Glu Val His His Gln Ser Glu Gln Glu Thr Ser Val 
            100                 105                 110         


Arg Lys Arg Arg Ile Lys Lys Ser Ser Arg Val Gln Pro Glu Phe Tyr 
        115                 120                 125             


His Ser Val Gln Gly Ala Ser Ile Arg Arg Pro Ser Ser Gly Asn Ala 
    130                 135                 140                 


Ser Tyr Arg Cys Ser Met Ser Ser Ser Ala Asp Phe Ser Asp Glu Asp 
145                 150                 155                 160 


Asp Phe Ser Gln Lys Ser Gly Ser Ala Ser Pro Ala Pro Gly Asp Thr 
                165                 170                 175     


Leu Pro Trp Asn Leu Pro Lys His Glu Arg Ser Lys Arg Lys Ile Gln 
            180                 185                 190         


Gly Gly Ser Val Leu Asp Pro Ala Glu Arg Ala Val Leu Arg Ile Ala 
        195                 200                 205             


Asp Glu Arg Asp Lys Val Gln Lys Lys Thr Phe Thr Lys Trp Ile Asn 
    210                 215                 220                 


Gln His Leu Met Lys Val Arg Lys His Val Asn Asp Leu Tyr Glu Asp 
225                 230                 235                 240 


Leu Arg Asp Gly His Asn Leu Ile Ser Leu Leu Glu Val Leu Ser Gly 
                245                 250                 255     


Asp Thr Leu Pro Arg Glu Lys Gly Arg Met Arg Phe His Arg Leu Gln 
            260                 265                 270         


Asn Val Gln Ile Ala Leu Asp Tyr Leu Lys Arg Arg Gln Val Lys Leu 
        275                 280                 285             


Val Asn Ile Arg Asn Asp Asp Ile Thr Asp Gly Asn Pro Lys Leu Thr 
    290                 295                 300                 


Leu Gly Leu Ile Trp Thr Ile Ile Leu His Phe Gln Ile Ser Asp Ile 
305                 310                 315                 320 


His Val Thr Gly Glu Ser Glu Asp Met Ser Ala Lys Glu Arg Leu Leu 
                325                 330                 335     


Leu Trp Thr Gln Gln Ala Thr Glu Gly Tyr Ala Gly Ile Arg Cys Glu 
            340                 345                 350         


Asn Phe Thr Thr Cys Trp Arg Asp Gly Lys Leu Phe Asn Ala Ile Ile 
        355                 360                 365             


His Lys Tyr Arg Pro Asp Leu Ile Asp Met Asn Thr Val Ala Val Gln 
    370                 375                 380                 


Ser Asn Leu Ala Asn Leu Glu His Ala Phe Tyr Val Ala Glu Lys Ile 
385                 390                 395                 400 


Gly Val Ile Arg Leu Leu Asp Pro Glu Asp Val Asp Val Ser Ser Pro 
                405                 410                 415     


Asp Glu Lys Ser Val Ile Thr Tyr Val Ser Ser Leu Tyr Asp Ala Phe 
            420                 425                 430         


Pro Lys Val Pro Glu Gly Gly Glu Gly Ile Gly Ala Asn Asp Val Glu 
        435                 440                 445             


Val Lys Trp Ile Glu Tyr Gln Asn Met Val Asn Tyr Leu Ile Gln Trp 
    450                 455                 460                 


Ile Arg His His Val Thr Thr Met Ser Glu Arg Thr Phe Pro Asn Asn 
465                 470                 475                 480 


Pro Val Glu Leu Lys Ala Leu Tyr Asn Gln Tyr Leu Gln Phe Lys Glu 
                485                 490                 495     


Thr Glu Ile Pro Pro Lys Glu Thr Glu Lys Ser Lys Ile Lys Arg Leu 
            500                 505                 510         


Tyr Lys Leu Leu Glu Ile Trp Ile Glu Phe Gly Arg Ile Lys Leu Leu 
        515                 520                 525             


Gln Gly Tyr His Pro Asn Asp Ile Glu Lys Glu Trp Gly Lys Leu Ile 
    530                 535                 540                 


Ile Ala Met Leu Glu Arg Glu Lys Ala Leu Arg Pro Glu Val Glu Arg 
545                 550                 555                 560 


Leu Glu Met Leu Gln Gln Ile Ala Asn Arg Val Gln Arg Asp Ser Val 
                565                 570                 575     


Ile Cys Glu Asp Lys Leu Ile Leu Ala Gly Asn Ala Leu Gln Ser Asp 
            580                 585                 590         


Ser Lys Arg Leu Glu Ser Gly Val Gln Phe Gln Asn Glu Ala Glu Ile 
        595                 600                 605             


Ala Gly Tyr Ile Leu Glu Cys Glu Asn Leu Leu Arg Gln His Val Ile 
    610                 615                 620                 


Asp Val Gln Ile Leu Ile Asp Gly Lys Tyr Tyr Gln Ala Asp Gln Leu 
625                 630                 635                 640 


Val Gln Arg Val Ala Lys Leu Arg Asp Glu Ile Met Ala Leu Arg Asn 
                645                 650                 655     


Glu Cys Ser Ser Val Tyr Ser Lys Gly Arg Ile Leu Thr Thr Glu Gln 
            660                 665                 670         


Thr Lys Leu Met Ile Ser Gly Ile Thr Gln Ser Leu Asn Ser Gly Phe 
        675                 680                 685             


Ala Gln Thr Leu His Pro Ser Leu Thr Ser Gly Leu Thr Gln Ser Leu 
    690                 695                 700                 


Thr Pro Ser Leu Thr Ser Ser Ser Met Thr Ser Gly Leu Ser Ser Gly 
705                 710                 715                 720 


Met Thr Ser Arg Leu Thr Pro Ser Val Thr Pro Ala Tyr Thr Pro Gly 
                725                 730                 735     


Phe Pro Ser Gly Leu Val Pro Asn Phe Ser Ser Gly Val Glu Pro Asn 
            740                 745                 750         


Ser Leu Gln Thr Leu Lys Leu Met Gln Ile Arg Lys Pro Leu Leu Lys 
        755                 760                 765             


Ser Ser Leu Leu Asp Gln Asn Leu Thr Glu Glu Glu Ile Asn Met Lys 
    770                 775                 780                 


Phe Val Gln Asp Leu Leu Asn Trp Val Asp Glu Met Gln Val Gln Leu 
785                 790                 795                 800 


Asp Arg Thr Glu Trp Gly Ser Asp Leu Pro Ser Val Glu Ser His Leu 
                805                 810                 815     


Glu Asn His Lys Asn Val His Arg Ala Ile Glu Glu Phe Glu Ser Ser 
            820                 825                 830         


Leu Lys Glu Ala Lys Ile Ser Glu Ile Gln Met Thr Ala Pro Leu Lys 
        835                 840                 845             


Leu Thr Tyr Ala Glu Lys Leu His Arg Leu Glu Ser Gln Tyr Ala Lys 
    850                 855                 860                 


Leu Leu Asn Thr Ser Arg Asn Gln Glu Arg His Leu Asp Thr Leu His 
865                 870                 875                 880 


Asn Phe Val Ser Arg Ala Thr Asn Glu Leu Ile Trp Leu Asn Glu Lys 
                885                 890                 895     


Glu Glu Glu Glu Val Ala Tyr Asp Trp Ser Glu Arg Asn Thr Asn Ile 
            900                 905                 910         


Ala Arg Lys Lys Asp Tyr His Ala Glu Leu Met Arg Glu Leu Asp Gln 
        915                 920                 925             


Lys Glu Glu Asn Ile Lys Ser Val Gln Glu Ile Ala Glu Gln Leu Leu 
    930                 935                 940                 


Leu Glu Asn His Pro Ala Arg Leu Thr Ile Glu Ala Tyr Arg Ala Ala 
945                 950                 955                 960 


Met Gln Thr Gln Trp Ser Trp Ile Leu Gln Leu Cys Gln Cys Val Glu 
                965                 970                 975     


Gln His Ile Lys Glu Asn Thr Ala Tyr Phe Glu Phe Phe Asn Asp Ala 
            980                 985                 990         


Lys Glu Ala Thr Asp Tyr Leu Arg  Asn Leu Lys Asp Ala  Ile Gln Arg 
        995                 1000                 1005             


Lys Tyr  Ser Cys Asp Arg Ser  Ser Ser Ile His Lys  Leu Glu Asp 
    1010                 1015                 1020             


Leu Val  Gln Glu Ser Met Glu  Glu Lys Glu Glu Leu  Leu Gln Tyr 
    1025                 1030                 1035             


Lys Ser  Thr Ile Ala Asn Leu  Met Gly Lys Ala Lys  Thr Ile Ile 
    1040                 1045                 1050             


Gln Leu  Lys Pro Arg Asn Ser  Asp Cys Pro Leu Lys  Thr Ser Ile 
    1055                 1060                 1065             


Pro Ile  Lys Ala Ile Cys Asp  Tyr Arg Gln Ile Glu  Ile Thr Ile 
    1070                 1075                 1080             


Tyr Lys  Asp Asp Glu Cys Val  Leu Ala Asn Asn Ser  His Arg Ala 
    1085                 1090                 1095             


Lys Trp  Lys Val Ile Ser Pro  Thr Gly Asn Glu Ala  Met Val Pro 
    1100                 1105                 1110             


Ser Val  Cys Phe Thr Val Pro  Pro Pro Asn Lys Glu  Ala Val Asp 
    1115                 1120                 1125             


Leu Ala  Asn Arg Ile Glu Gln  Gln Tyr Gln Asn Val  Leu Thr Leu 
    1130                 1135                 1140             


Trp His  Glu Ser His Ile Asn  Met Lys Ser Val Val  Ser Trp His 
    1145                 1150                 1155             


Tyr Leu  Ile Asn Glu Ile Asp  Arg Ile Arg Ala Ser  Asn Val Ala 
    1160                 1165                 1170             


Ser Ile  Lys Thr Met Leu Pro  Gly Glu His Gln Gln  Val Leu Ser 
    1175                 1180                 1185             


Asn Leu  Gln Ser Arg Phe Glu  Asp Phe Leu Glu Asp  Ser Gln Glu 
    1190                 1195                 1200             


Ser Gln  Val Phe Ser Gly Ser  Asp Ile Thr Gln Leu  Glu Lys Glu 
    1205                 1210                 1215             


Val Asn  Val Cys Lys Gln Tyr  Tyr Gln Glu Leu Leu  Lys Ser Ala 
    1220                 1225                 1230             


Glu Arg  Glu Glu Gln Glu Glu  Ser Val Tyr Asn Leu  Tyr Ile Ser 
    1235                 1240                 1245             


Glu Val  Arg Asn Ile Arg Leu  Arg Leu Glu Asn Cys  Glu Asp Arg 
    1250                 1255                 1260             


Leu Ile  Arg Gln Ile Arg Thr  Pro Leu Glu Arg Asp  Asp Leu His 
    1265                 1270                 1275             


Glu Ser  Val Phe Arg Ile Thr  Glu Gln Glu Lys Leu  Lys Lys Glu 
    1280                 1285                 1290             


Leu Glu  Arg Leu Lys Asp Asp  Leu Gly Thr Ile Thr  Asn Lys Cys 
    1295                 1300                 1305             


Glu Glu  Phe Phe Ser Gln Ala  Ala Ala Ser Ser Ser  Val Pro Thr 
    1310                 1315                 1320             


Leu Arg  Ser Glu Leu Asn Val  Val Leu Gln Asn Met  Asn Gln Val 
    1325                 1330                 1335             


Tyr Ser  Met Ser Ser Thr Tyr  Ile Asp Lys Leu Lys  Thr Val Asn 
    1340                 1345                 1350             


Leu Val  Leu Lys Asn Thr Gln  Ala Ala Glu Ala Leu  Val Lys Leu 
    1355                 1360                 1365             


Tyr Glu  Thr Lys Leu Cys Glu  Glu Glu Ala Val Ile  Ala Asp Lys 
    1370                 1375                 1380             


Asn Asn  Ile Glu Asn Leu Ile  Ser Thr Leu Lys Gln  Trp Arg Ser 
    1385                 1390                 1395             


Glu Val  Asp Glu Lys Arg Gln  Val Phe His Ala Leu  Glu Asp Glu 
    1400                 1405                 1410             


Leu Gln  Lys Ala Lys Ala Ile  Ser Asp Glu Met Phe  Lys Thr Tyr 
    1415                 1420                 1425             


Lys Glu  Arg Asp Leu Asp Phe  Asp Trp His Lys Glu  Lys Ala Asp 
    1430                 1435                 1440             


Gln Leu  Val Glu Arg Trp Gln  Asn Val His Val Gln  Ile Asp Asn 
    1445                 1450                 1455             


Arg Leu  Arg Asp Leu Glu Gly  Ile Gly Lys Ser Leu  Lys Tyr Tyr 
    1460                 1465                 1470             


Arg Asp  Thr Tyr His Pro Leu  Asp Asp Trp Ile Gln  Gln Val Glu 
    1475                 1480                 1485             


Thr Thr  Gln Arg Lys Ile Gln  Glu Asn Gln Pro Glu  Asn Ser Lys 
    1490                 1495                 1500             


Thr Leu  Ala Thr Gln Leu Asn  Gln Gln Lys Met Leu  Val Ser Glu 
    1505                 1510                 1515             


Ile Glu  Met Lys Gln Ser Lys  Met Asp Glu Cys Gln  Lys Tyr Ala 
    1520                 1525                 1530             


Glu Gln  Tyr Ser Ala Thr Val  Lys Asp Tyr Glu Leu  Gln Thr Met 
    1535                 1540                 1545             


Thr Tyr  Arg Ala Met Val Asp  Ser Gln Gln Lys Ser  Pro Val Lys 
    1550                 1555                 1560             


Arg Arg  Arg Met Gln Ser Ser  Ala Asp Leu Ile Ile  Gln Glu Phe 
    1565                 1570                 1575             


Met Asp  Leu Arg Thr Arg Tyr  Thr Ala Leu Val Thr  Leu Met Thr 
    1580                 1585                 1590             


Gln Tyr  Ile Lys Phe Ala Gly  Asp Ser Leu Lys Arg  Leu Glu Glu 
    1595                 1600                 1605             


Glu Glu  Lys Ser Leu Glu Glu  Glu Lys Lys Glu His  Val Glu Lys 
    1610                 1615                 1620             


Ala Lys  Glu Leu Gln Lys Trp  Val Ser Asn Ile Ser  Lys Thr Leu 
    1625                 1630                 1635             


Lys Asp  Ala Glu Lys Ala Gly  Lys Pro Pro Phe Ser  Lys Gln Lys 
    1640                 1645                 1650             


Ile Ser  Ser Glu Glu Ile Ser  Thr Lys Lys Glu Gln  Leu Ser Glu 
    1655                 1660                 1665             


Ala Leu  Gln Thr Ile Gln Leu  Phe Leu Ala Lys His  Gly Asp Lys 
    1670                 1675                 1680             


Met Thr  Asp Glu Glu Arg Asn  Glu Leu Glu Lys Gln  Val Lys Thr 
    1685                 1690                 1695             


Leu Gln  Glu Ser Tyr Asn Leu  Leu Phe Ser Glu Ser  Leu Lys Gln 
    1700                 1705                 1710             


Leu Gln  Glu Ser Gln Thr Ser  Gly Asp Val Lys Val  Glu Glu Lys 
    1715                 1720                 1725             


Ile Val  Ala Glu Arg Gln Gln  Glu Tyr Lys Glu Lys  Leu Gln Gly 
    1730                 1735                 1740             


Ile Cys  Asp Leu Leu Thr Gln  Thr Glu Asn Arg Leu  Ile Gly His 
    1745                 1750                 1755             


Gln Glu  Ala Phe Met Ile Gly  Asp Gly Thr Val Glu  Leu Lys Lys 
    1760                 1765                 1770             


Tyr Gln  Ser Lys Gln Glu Glu  Leu Gln Lys Asp Met  Gln Gly Ser 
    1775                 1780                 1785             


Ala Gln  Ala Leu Ala Glu Val  Val Lys Asn Thr Glu  Asn Phe Leu 
    1790                 1795                 1800             


Lys Glu  Asn Gly Glu Lys Leu  Ser Gln Glu Asp Lys  Ala Leu Ile 
    1805                 1810                 1815             


Glu Gln  Lys Leu Asn Glu Ala  Lys Ile Lys Cys Glu  Gln Leu Asn 
    1820                 1825                 1830             


Leu Lys  Ala Glu Gln Ser Lys  Lys Glu Leu Asp Lys  Val Val Thr 
    1835                 1840                 1845             


Thr Ala  Ile Lys Glu Glu Thr  Glu Lys Val Ala Ala  Val Lys Gln 
    1850                 1855                 1860             


Leu Glu  Glu Ser Lys Thr Lys  Ile Glu Asn Leu Leu  Asp Trp Leu 
    1865                 1870                 1875             


Ser Asn  Val Asp Lys Asp Ser  Glu Arg Ala Gly Thr  Lys His Lys 
    1880                 1885                 1890             


Gln Val  Ile Glu Gln Asn Gly  Thr His Phe Gln Glu  Gly Asp Gly 
    1895                 1900                 1905             


Lys Ser  Ala Ile Gly Glu Glu  Asp Glu Val Asn Gly  Asn Leu Leu 
    1910                 1915                 1920             


Glu Thr  Asp Val Asp Gly Gln  Val Gly Thr Thr Gln  Glu Asn Leu 
    1925                 1930                 1935             


Asn Gln  Gln Tyr Gln Lys Val  Lys Ala Gln His Glu  Lys Ile Ile 
    1940                 1945                 1950             


Ser Gln  His Gln Ala Val Ile  Ile Ala Thr Gln Ser  Ala Gln Val 
    1955                 1960                 1965             


Leu Leu  Glu Lys Gln Gly Gln  Tyr Leu Ser Pro Glu  Glu Lys Glu 
    1970                 1975                 1980             


Lys Leu  Gln Lys Asn Met Lys  Glu Leu Lys Val His  Tyr Glu Thr 
    1985                 1990                 1995             


Ala Leu  Ala Glu Ser Glu Lys  Lys Met Lys Leu Thr  His Ser Leu 
    2000                 2005                 2010             


Gln Glu  Glu Leu Glu Lys Phe  Asp Ala Asp Tyr Thr  Glu Phe Glu 
    2015                 2020                 2025             


His Trp  Leu Gln Gln Ser Glu  Gln Glu Leu Glu Asn  Leu Glu Ala 
    2030                 2035                 2040             


Gly Ala  Asp Asp Ile Asn Gly  Leu Met Thr Lys Leu  Lys Arg Gln 
    2045                 2050                 2055             


Lys Ser  Phe Ser Glu Asp Val  Ile Ser His Lys Gly  Asp Leu Arg 
    2060                 2065                 2070             


Tyr Ile  Thr Ile Ser Gly Asn  Arg Val Leu Glu Ala  Ala Lys Ser 
    2075                 2080                 2085             


Cys Ser  Lys Arg Asp Gly Gly  Lys Val Asp Thr Ser  Ala Thr His 
    2090                 2095                 2100             


Arg Glu  Val Gln Arg Lys Leu  Asp His Ala Thr Asp  Arg Phe Arg 
    2105                 2110                 2115             


Ser Leu  Tyr Ser Lys Cys Asn  Val Leu Gly Asn Asn  Leu Lys Asp 
    2120                 2125                 2130             


Leu Val  Asp Lys Tyr Gln His  Tyr Glu Asp Ala Ser  Cys Gly Leu 
    2135                 2140                 2145             


Leu Ala  Gly Leu Gln Ala Cys  Glu Ala Thr Ala Ser  Lys His Leu 
    2150                 2155                 2160             


Ser Glu  Pro Ile Ala Val Asp  Pro Lys Asn Leu Gln  Arg Gln Leu 
    2165                 2170                 2175             


Glu Glu  Thr Lys Ala Leu Gln  Gly Gln Ile Ser Ser  Gln Gln Val 
    2180                 2185                 2190             


Ala Val  Glu Lys Leu Lys Lys  Thr Ala Glu Val Leu  Leu Asp Ala 
    2195                 2200                 2205             


Arg Gly  Ser Leu Leu Pro Ala  Lys Asn Asp Ile Gln  Lys Thr Leu 
    2210                 2215                 2220             


Asp Asp  Ile Val Gly Arg Tyr  Glu Asp Leu Ser Lys  Ser Val Asn 
    2225                 2230                 2235             


Glu Arg  Asn Glu Lys Leu Gln  Ile Thr Leu Thr Arg  Ser Leu Ser 
    2240                 2245                 2250             


Val Gln  Asp Gly Leu Asp Glu  Met Leu Asp Trp Met  Gly Asn Val 
    2255                 2260                 2265             


Glu Ser  Ser Leu Lys Glu Gln  Gly Gln Val Pro Leu  Asn Ser Thr 
    2270                 2275                 2280             


Ala Leu  Gln Asp Ile Ile Ser  Lys Asn Ile Met Leu  Glu Gln Asp 
    2285                 2290                 2295             


Ile Ala  Gly Arg Gln Ser Ser  Ile Asn Ala Met Asn  Glu Lys Val 
    2300                 2305                 2310             


Lys Lys  Phe Met Glu Thr Thr  Asp Pro Ser Thr Ala  Ser Ser Leu 
    2315                 2320                 2325             


Gln Ala  Lys Met Lys Asp Leu  Ser Ala Arg Phe Ser  Glu Ala Ser 
    2330                 2335                 2340             


His Lys  His Lys Glu Thr Leu  Ala Lys Met Glu Glu  Leu Lys Thr 
    2345                 2350                 2355             


Lys Val  Glu Leu Phe Glu Asn  Leu Ser Glu Lys Leu  Gln Thr Phe 
    2360                 2365                 2370             


Leu Glu  Thr Lys Thr Gln Ala  Leu Thr Glu Val Asp  Val Pro Gly 
    2375                 2380                 2385             


Lys Asp  Val Thr Glu Leu Ser  Gln Tyr Met Gln Glu  Ser Thr Ser 
    2390                 2395                 2400             


Glu Phe  Leu Glu His Lys Lys  His Leu Glu Val Leu  His Ser Leu 
    2405                 2410                 2415             


Leu Lys  Glu Ile Ser Ser His  Gly Leu Pro Ser Asp  Lys Ala Leu 
    2420                 2425                 2430             


Val Leu  Glu Lys Thr Asn Asn  Leu Ser Lys Lys Phe  Lys Glu Met 
    2435                 2440                 2445             


Glu Asp  Thr Ile Lys Glu Lys  Lys Glu Ala Val Thr  Ser Cys Gln 
    2450                 2455                 2460             


Glu Gln  Leu Asp Ala Phe Gln  Val Leu Val Lys Ser  Leu Lys Ser 
    2465                 2470                 2475             


Trp Ile  Lys Glu Thr Thr Lys  Lys Val Pro Ile Val  Gln Pro Ser 
    2480                 2485                 2490             


Phe Gly  Ala Glu Asp Leu Gly  Lys Ser Leu Glu Asp  Thr Lys Lys 
    2495                 2500                 2505             


Leu Gln  Glu Lys Trp Ser Leu  Lys Thr Pro Glu Ile  Gln Lys Val 
    2510                 2515                 2520             


Asn Asn  Ser Gly Ile Ser Leu  Cys Asn Leu Ile Ser  Ala Val Thr 
    2525                 2530                 2535             


Thr Pro  Ala Lys Ala Ile Ala  Ala Val Lys Ser Gly  Gly Ala Val 
    2540                 2545                 2550             


Leu Asn  Gly Glu Gly Thr Ala  Thr Asn Thr Glu Glu  Phe Trp Ala 
    2555                 2560                 2565             


Asn Lys  Gly Leu Thr Ser Ile  Lys Lys Asp Met Thr  Asp Ile Ser 
    2570                 2575                 2580             


His Gly  Tyr Glu Asp Leu Gly  Leu Leu Leu Lys Asp  Lys Ile Ala 
    2585                 2590                 2595             


Glu Leu  Asn Thr Lys Leu Ser  Lys Leu Gln Lys Ala  Gln Glu Glu 
    2600                 2605                 2610             


Ser Ser  Ala Met Met Gln Trp  Leu Gln Lys Met Asn  Lys Thr Ala 
    2615                 2620                 2625             


Thr Lys  Trp Gln Gln Thr Pro  Ala Pro Thr Asp Thr  Glu Ala Val 
    2630                 2635                 2640             


Lys Thr  Gln Val Glu Gln Asn  Lys Ser Phe Glu Ala  Glu Leu Lys 
    2645                 2650                 2655             


Gln Asn  Val Asn Lys Val Gln  Glu Leu Lys Asp Lys  Leu Thr Glu 
    2660                 2665                 2670             


Leu Leu  Glu Glu Asn Pro Asp  Thr Pro Glu Ala Pro  Arg Trp Lys 
    2675                 2680                 2685             


Gln Met  Leu Thr Glu Ile Asp  Ser Lys Trp Gln Glu  Leu Asn Gln 
    2690                 2695                 2700             


Leu Thr  Ile Asp Arg Gln Gln  Lys Leu Glu Glu Ser  Ser Asn Asn 
    2705                 2710                 2715             


Leu Thr  Gln Phe Gln Thr Val  Glu Ala Gln Leu Lys  Gln Trp Leu 
    2720                 2725                 2730             


Val Glu  Lys Glu Leu Met Val  Ser Val Leu Gly Pro  Leu Ser Ile 
    2735                 2740                 2745             


Asp Pro  Asn Met Leu Asn Thr  Gln Arg Gln Gln Val  Gln Ile Leu 
    2750                 2755                 2760             


Leu Gln  Glu Phe Ala Thr Arg  Lys Pro Gln Tyr Glu  Gln Leu Thr 
    2765                 2770                 2775             


Ala Ala  Gly Gln Gly Ile Leu  Ser Arg Pro Gly Glu  Asp Pro Ser 
    2780                 2785                 2790             


Leu Arg  Gly Ile Val Lys Glu  Gln Leu Ala Ala Val  Thr Gln Lys 
    2795                 2800                 2805             


Trp Asp  Ser Leu Thr Gly Gln  Leu Ser Asp Arg Cys  Asp Trp Ile 
    2810                 2815                 2820             


Asp Gln  Ala Ile Val Lys Ser  Thr Gln Tyr Gln Ser  Leu Leu Arg 
    2825                 2830                 2835             


Ser Leu  Ser Asp Lys Leu Ser  Asp Leu Asp Asn Lys  Leu Ser Ser 
    2840                 2845                 2850             


Ser Leu  Ala Val Ser Thr His  Pro Asp Ala Met Asn  Gln Gln Leu 
    2855                 2860                 2865             


Glu Thr  Ala Gln Lys Met Lys  Gln Glu Ile Gln Gln  Glu Lys Lys 
    2870                 2875                 2880             


Gln Ile  Lys Val Ala Gln Ala  Leu Cys Glu Asp Leu  Ser Ala Leu 
    2885                 2890                 2895             


Val Lys  Glu Glu Tyr Leu Lys  Ala Glu Leu Ser Arg  Gln Leu Glu 
    2900                 2905                 2910             


Gly Ile  Leu Lys Ser Phe Lys  Asp Val Glu Gln Lys  Ala Glu Asn 
    2915                 2920                 2925             


His Val  Gln His Leu Gln Ser  Ala Cys Ala Ser Ser  His Gln Phe 
    2930                 2935                 2940             


Gln Gln  Met Ser Arg Asp Phe  Gln Ala Trp Leu Asp  Thr Lys Lys 
    2945                 2950                 2955             


Glu Glu  Gln Asn Lys Ser His  Pro Ile Ser Ala Lys  Leu Asp Val 
    2960                 2965                 2970             


Leu Glu  Ser Leu Ile Lys Asp  His Lys Asp Phe Ser  Lys Thr Leu 
    2975                 2980                 2985             


Thr Ala  Gln Ser His Met Tyr  Glu Lys Thr Ile Ala  Glu Gly Glu 
    2990                 2995                 3000             


Asn Leu  Leu Leu Lys Thr Gln  Gly Ser Glu Lys Ala  Ala Leu Gln 
    3005                 3010                 3015             


Leu Gln  Leu Asn Thr Ile Lys  Thr Asn Trp Asp Thr  Phe Asn Lys 
    3020                 3025                 3030             


Gln Val  Lys Glu Arg Glu Asn  Lys Leu Lys Glu Ser  Leu Glu Lys 
    3035                 3040                 3045             


Ala Leu  Lys Tyr Lys Glu Gln  Val Glu Thr Leu Trp  Pro Trp Ile 
    3050                 3055                 3060             


Asp Lys  Cys Gln Asn Asn Leu  Glu Glu Ile Lys Phe  Cys Leu Asp 
    3065                 3070                 3075             


Pro Ala  Glu Gly Glu Asn Ser  Ile Ala Lys Leu Lys  Ser Leu Gln 
    3080                 3085                 3090             


Lys Glu  Met Asp Gln His Phe  Gly Met Val Glu Leu  Leu Asn Asn 
    3095                 3100                 3105             


Thr Ala  Asn Ser Leu Leu Ser  Val Cys Glu Ile Asp  Lys Glu Val 
    3110                 3115                 3120             


Val Thr  Asp Glu Asn Lys Ser  Leu Ile Gln Lys Val  Asp Met Val 
    3125                 3130                 3135             


Thr Glu  Gln Leu His Ser Lys  Lys Phe Cys Leu Glu  Asn Met Thr 
    3140                 3145                 3150             


Gln Lys  Phe Lys Glu Phe Gln  Glu Val Ser Lys Glu  Ser Lys Arg 
    3155                 3160                 3165             


Gln Leu  Gln Cys Ala Lys Glu  Gln Leu Asp Ile His  Asp Ser Leu 
    3170                 3175                 3180             


Gly Ser  Gln Ala Tyr Ser Asn  Lys Tyr Leu Thr Met  Leu Gln Thr 
    3185                 3190                 3195             


Gln Gln  Lys Ser Leu Gln Ala  Leu Lys His Gln Val  Asp Leu Ala 
    3200                 3205                 3210             


Lys Arg  Leu Ala Gln Asp Leu  Val Val Glu Ala Ser  Asp Ser Lys 
    3215                 3220                 3225             


Gly Thr  Ser Asp Val Leu Leu  Gln Val Glu Thr Ile  Ala Gln Glu 
    3230                 3235                 3240             


His Ser  Thr Leu Ser Gln Gln  Val Asp Glu Lys Cys  Ser Phe Leu 
    3245                 3250                 3255             


Glu Thr  Lys Leu Gln Gly Ile  Gly His Phe Gln Asn  Thr Ile Arg 
    3260                 3265                 3270             


Glu Met  Phe Ser Gln Phe Ala  Glu Phe Asp Asp Glu  Leu Asp Ser 
    3275                 3280                 3285             


Met Ala  Pro Val Gly Arg Asp  Ala Glu Thr Leu Gln  Lys Gln Lys 
    3290                 3295                 3300             


Glu Thr  Ile Lys Ala Phe Leu  Lys Lys Leu Glu Ala  Leu Met Ala 
    3305                 3310                 3315             


Ser Asn  Asp Asn Ala Asn Lys  Thr Cys Lys Met Met  Leu Ala Thr 
    3320                 3325                 3330             


Glu Glu  Thr Ser Pro Asp Leu  Val Gly Ile Lys Arg  Asp Leu Glu 
    3335                 3340                 3345             


Ala Leu  Ser Lys Gln Cys Asn  Lys Leu Leu Asp Arg  Ala Gln Ala 
    3350                 3355                 3360             


Arg Glu  Glu Gln Val Glu Gly  Thr Ile Lys Arg Leu  Glu Glu Phe 
    3365                 3370                 3375             


Tyr Ser  Lys Leu Lys Glu Phe  Ser Ile Leu Leu Gln  Lys Ala Glu 
    3380                 3385                 3390             


Glu His  Glu Glu Ser Gln Gly  Pro Val Gly Met Glu  Thr Glu Thr 
    3395                 3400                 3405             


Ile Asn  Gln Gln Leu Asn Met  Phe Lys Val Phe Gln  Lys Glu Glu 
    3410                 3415                 3420             


Ile Glu  Pro Leu Gln Gly Lys  Gln Gln Asp Val Asn  Trp Leu Gly 
    3425                 3430                 3435             


Gln Gly  Leu Ile Gln Ser Ala  Ala Lys Ser Thr Ser  Thr Gln Gly 
    3440                 3445                 3450             


Leu Glu  His Asp Leu Asp Asp  Val Asn Ala Arg Trp  Lys Thr Leu 
    3455                 3460                 3465             


Asn Lys  Lys Val Ala Gln Arg  Ala Ala Gln Leu Gln  Glu Ala Leu 
    3470                 3475                 3480             


Leu His  Cys Gly Arg Phe Gln  Asp Ala Leu Glu Ser  Leu Leu Ser 
    3485                 3490                 3495             


Trp Met  Val Asp Thr Glu Glu  Leu Val Ala Asn Gln  Lys Pro Pro 
    3500                 3505                 3510             


Ser Ala  Glu Phe Lys Val Val  Lys Ala Gln Ile Gln  Glu Gln Lys 
    3515                 3520                 3525             


Leu Leu  Gln Arg Leu Leu Asp  Asp Arg Lys Ser Thr  Val Glu Val 
    3530                 3535                 3540             


Ile Lys  Arg Glu Gly Glu Lys  Ile Ala Thr Thr Ala  Glu Pro Ala 
    3545                 3550                 3555             


Asp Lys  Val Lys Ile Leu Lys  Gln Leu Ser Leu Leu  Asp Ser Arg 
    3560                 3565                 3570             


Trp Glu  Ala Leu Leu Asn Lys  Ala Glu Thr Arg Asn  Arg Gln Leu 
    3575                 3580                 3585             


Glu Gly  Ile Ser Val Val Ala  Gln Gln Phe His Glu  Thr Leu Glu 
    3590                 3595                 3600             


Pro Leu  Asn Glu Trp Leu Thr  Thr Ile Glu Lys Arg  Leu Val Asn 
    3605                 3610                 3615             


Cys Glu  Pro Ile Gly Thr Gln  Ala Ser Lys Leu Glu  Glu Gln Ile 
    3620                 3625                 3630             


Ala Gln  His Lys Ala Leu Glu  Asp Asp Ile Ile Asn  His Asn Lys 
    3635                 3640                 3645             


His Leu  His Gln Ala Val Ser  Ile Gly Gln Ser Leu  Lys Val Leu 
    3650                 3655                 3660             


Ser Ser  Arg Glu Asp Lys Asp  Met Val Gln Ser Lys  Leu Asp Phe 
    3665                 3670                 3675             


Ser Gln  Val Trp Tyr Ile Glu  Ile Gln Glu Lys Ser  His Ser Arg 
    3680                 3685                 3690             


Ser Glu  Leu Leu Gln Gln Ala  Leu Cys Asn Ala Lys  Ile Phe Gly 
    3695                 3700                 3705             


Glu Asp  Glu Val Glu Leu Met  Asn Trp Leu Asn Glu  Val His Asp 
    3710                 3715                 3720             


Lys Leu  Ser Lys Leu Ser Val  Gln Asp Tyr Ser Thr  Glu Gly Leu 
    3725                 3730                 3735             


Trp Lys  Gln Gln Ser Glu Leu  Arg Val Leu Gln Glu  Asp Ile Leu 
    3740                 3745                 3750             


Leu Arg  Lys Gln Asn Val Asp  Gln Ala Leu Leu Asn  Gly Leu Glu 
    3755                 3760                 3765             


Leu Leu  Lys Gln Thr Thr Gly  Asp Glu Val Leu Ile  Ile Gln Asp 
    3770                 3775                 3780             


Lys Leu  Glu Ala Ile Lys Ala  Arg Tyr Lys Asp Ile  Thr Lys Leu 
    3785                 3790                 3795             


Ser Thr  Asp Val Ala Lys Thr  Leu Glu Gln Ala Leu  Gln Leu Ala 
    3800                 3805                 3810             


Arg Arg  Leu His Ser Thr His  Glu Glu Leu Cys Thr  Trp Leu Asp 
    3815                 3820                 3825             


Lys Val  Glu Val Glu Leu Leu  Ser Tyr Glu Thr Gln  Val Leu Lys 
    3830                 3835                 3840             


Gly Glu  Glu Ala Ser Gln Ala  Gln Met Arg Pro Lys  Glu Leu Lys 
    3845                 3850                 3855             


Lys Glu  Ala Lys Asn Asn Lys  Ala Leu Leu Asp Ser  Leu Asn Glu 
    3860                 3865                 3870             


Val Ser  Ser Ala Leu Leu Glu  Leu Val Pro Trp Arg  Ala Arg Glu 
    3875                 3880                 3885             


Gly Leu  Glu Lys Met Val Ala  Glu Asp Asn Glu Arg  Tyr Arg Leu 
    3890                 3895                 3900             


Val Ser  Asp Thr Ile Thr Gln  Lys Val Glu Glu Ile  Asp Ala Ala 
    3905                 3910                 3915             


Ile Leu  Arg Ser Gln Gln Phe  Asp Gln Ala Ala Asp  Ala Glu Leu 
    3920                 3925                 3930             


Ser Trp  Ile Thr Glu Thr Glu  Lys Lys Leu Met Ser  Leu Gly Asp 
    3935                 3940                 3945             


Ile Arg  Leu Glu Gln Asp Gln  Thr Ser Ala Gln Leu  Gln Val Gln 
    3950                 3955                 3960             


Lys Thr  Phe Thr Met Glu Ile  Leu Arg His Lys Asp  Ile Ile Asp 
    3965                 3970                 3975             


Asp Leu  Val Lys Ser Gly His  Lys Ile Met Thr Ala  Cys Ser Glu 
    3980                 3985                 3990             


Glu Glu  Lys Gln Ser Met Lys  Lys Lys Leu Asp Lys  Val Leu Lys 
    3995                 4000                 4005             


Asn Tyr  Asp Thr Ile Cys Gln  Ile Asn Ser Glu Arg  Tyr Leu Gln 
    4010                 4015                 4020             


Leu Glu  Arg Ala Gln Ser Leu  Val Asn Gln Phe Trp  Glu Thr Tyr 
    4025                 4030                 4035             


Glu Glu  Leu Trp Pro Trp Leu  Thr Glu Thr Gln Ser  Ile Ile Ser 
    4040                 4045                 4050             


Gln Leu  Pro Ala Pro Ala Leu  Glu Tyr Glu Thr Leu  Arg Gln Gln 
    4055                 4060                 4065             


Gln Glu  Glu His Arg Gln Leu  Arg Glu Leu Ile Ala  Glu His Lys 
    4070                 4075                 4080             


Pro His  Ile Asp Lys Met Asn  Lys Thr Gly Pro Gln  Leu Leu Glu 
    4085                 4090                 4095             


Leu Ser  Pro Gly Glu Gly Phe  Ser Ile Gln Glu Lys  Tyr Val Ala 
    4100                 4105                 4110             


Ala Asp  Thr Leu Tyr Ser Gln  Ile Lys Glu Asp Val  Lys Lys Arg 
    4115                 4120                 4125             


Ala Val  Ala Leu Asp Glu Ala  Ile Ser Gln Ser Thr  Gln Phe His 
    4130                 4135                 4140             


Asp Lys  Ile Asp Gln Ile Leu  Glu Ser Leu Glu Arg  Ile Val Glu 
    4145                 4150                 4155             


Arg Leu  Arg Gln Pro Pro Ser  Ile Ser Ala Glu Val  Glu Lys Ile 
    4160                 4165                 4170             


Lys Glu  Gln Ile Ser Glu Asn  Lys Asn Val Ser Val  Asp Met Glu 
    4175                 4180                 4185             


Lys Leu  Gln Pro Leu Tyr Glu  Thr Leu Lys Gln Arg  Gly Glu Glu 
    4190                 4195                 4200             


Met Ile  Ala Arg Ser Gly Gly  Thr Asp Lys Asp Ile  Ser Ala Lys 
    4205                 4210                 4215             


Ala Val  Gln Asp Lys Leu Asp  Gln Met Val Phe Ile  Trp Glu Asn 
    4220                 4225                 4230             


Ile His  Thr Leu Val Glu Glu  Arg Glu Ala Lys Leu  Leu Asp Val 
    4235                 4240                 4245             


Met Glu  Leu Ala Glu Lys Phe  Trp Cys Asp His Met  Ser Leu Ile 
    4250                 4255                 4260             


Val Thr  Ile Lys Asp Thr Gln  Asp Phe Ile Arg Asp  Leu Glu Asp 
    4265                 4270                 4275             


Pro Gly  Ile Asp Pro Ser Val  Val Lys Gln Gln Gln  Glu Ala Ala 
    4280                 4285                 4290             


Glu Thr  Ile Arg Glu Glu Ile  Asp Gly Leu Gln Glu  Glu Leu Asp 
    4295                 4300                 4305             


Ile Val  Ile Asn Leu Gly Ser  Glu Leu Ile Ala Ala  Cys Gly Glu 
    4310                 4315                 4320             


Pro Asp  Lys Pro Ile Val Lys  Lys Ser Ile Asp Glu  Leu Asn Ser 
    4325                 4330                 4335             


Ala Trp  Asp Ser Leu Asn Lys  Ala Trp Lys Asp Arg  Ile Asp Lys 
    4340                 4345                 4350             


Leu Glu  Glu Ala Met Gln Ala  Ala Val Gln Tyr Gln  Asp Gly Leu 
    4355                 4360                 4365             


Gln Ala  Val Phe Asp Trp Val  Asp Ile Ala Gly Gly  Lys Leu Ala 
    4370                 4375                 4380             


Ser Met  Ser Pro Ile Gly Thr  Asp Leu Glu Thr Val  Lys Gln Gln 
    4385                 4390                 4395             


Ile Glu  Glu Leu Lys Gln Phe  Lys Ser Glu Ala Tyr  Gln Gln Gln 
    4400                 4405                 4410             


Ile Glu  Met Glu Arg Leu Asn  His Gln Ala Glu Leu  Leu Leu Lys 
    4415                 4420                 4425             


Lys Val  Thr Glu Glu Ser Asp  Lys His Thr Val Gln  Asp Pro Leu 
    4430                 4435                 4440             


Met Glu  Leu Lys Leu Ile Trp  Asp Ser Leu Glu Glu  Arg Ile Ile 
    4445                 4450                 4455             


Asn Arg  Gln His Lys Leu Glu  Gly Ala Leu Leu Ala  Leu Gly Gln 
    4460                 4465                 4470             


Phe Gln  His Ala Leu Asp Glu  Leu Leu Ala Trp Leu  Thr His Thr 
    4475                 4480                 4485             


Glu Gly  Leu Leu Ser Glu Gln  Lys Pro Val Gly Gly  Asp Pro Lys 
    4490                 4495                 4500             


Ala Ile  Glu Ile Glu Leu Ala  Lys His His Val Leu  Gln Asn Asp 
    4505                 4510                 4515             


Val Leu  Ala His Gln Ser Thr  Val Glu Ala Val Asn  Lys Ala Gly 
    4520                 4525                 4530             


Asn Asp  Leu Ile Glu Ser Ser  Ala Gly Glu Glu Ala  Ser Asn Leu 
    4535                 4540                 4545             


Gln Asn  Lys Leu Glu Val Leu  Asn Gln Arg Trp Gln  Asn Val Leu 
    4550                 4555                 4560             


Glu Lys  Thr Glu Gln Arg Lys  Gln Gln Leu Asp Gly  Ala Leu Arg 
    4565                 4570                 4575             


Gln Ala  Lys Gly Phe His Gly  Glu Ile Glu Asp Leu  Gln Gln Trp 
    4580                 4585                 4590             


Leu Thr  Asp Thr Glu Arg His  Leu Leu Ala Ser Lys  Pro Leu Gly 
    4595                 4600                 4605             


Gly Leu  Pro Glu Thr Ala Lys  Glu Gln Leu Asn Val  His Met Glu 
    4610                 4615                 4620             


Val Cys  Ala Ala Phe Glu Ala  Lys Glu Glu Thr Tyr  Lys Ser Leu 
    4625                 4630                 4635             


Met Gln  Lys Gly Gln Gln Met  Leu Ala Arg Cys Pro  Lys Ser Ala 
    4640                 4645                 4650             


Glu Thr  Asn Ile Asp Gln Asp  Ile Asn Asn Leu Lys  Glu Lys Trp 
    4655                 4660                 4665             


Glu Ser  Val Glu Thr Lys Leu  Asn Glu Arg Lys Thr  Lys Leu Glu 
    4670                 4675                 4680             


Glu Ala  Leu Asn Leu Ala Met  Glu Phe His Asn Ser  Leu Gln Asp 
    4685                 4690                 4695             


Phe Ile  Asn Trp Leu Thr Gln  Ala Glu Gln Thr Leu  Asn Val Ala 
    4700                 4705                 4710             


Ser Arg  Pro Ser Leu Ile Leu  Asp Thr Val Leu Phe  Gln Ile Asp 
    4715                 4720                 4725             


Glu His  Lys Val Phe Ala Asn  Glu Val Asn Ser His  Arg Glu Gln 
    4730                 4735                 4740             


Ile Ile  Glu Leu Asp Lys Thr  Gly Thr His Leu Lys  Tyr Phe Ser 
    4745                 4750                 4755             


Gln Lys  Gln Asp Val Val Leu  Ile Lys Asn Leu Leu  Ile Ser Val 
    4760                 4765                 4770             


Gln Ser  Arg Trp Glu Lys Val  Val Gln Arg Leu Val  Glu Arg Gly 
    4775                 4780                 4785             


Arg Ser  Leu Asp Asp Ala Arg  Lys Arg Ala Lys Gln  Phe His Glu 
    4790                 4795                 4800             


Ala Trp  Ser Lys Leu Met Glu  Trp Leu Glu Glu Ser  Glu Lys Ser 
    4805                 4810                 4815             


Leu Asp  Ser Glu Leu Glu Ile  Ala Asn Asp Pro Asp  Lys Ile Lys 
    4820                 4825                 4830             


Thr Gln  Leu Ala Gln His Lys  Glu Phe Gln Lys Ser  Leu Gly Ala 
    4835                 4840                 4845             


Lys His  Ser Val Tyr Asp Thr  Thr Asn Arg Thr Gly  Arg Ser Leu 
    4850                 4855                 4860             


Lys Glu  Lys Thr Ser Leu Ala  Asp Asp Asn Leu Lys  Leu Asp Asp 
    4865                 4870                 4875             


Met Leu  Ser Glu Leu Arg Asp  Lys Trp Asp Thr Ile  Cys Gly Lys 
    4880                 4885                 4890             


Ser Val  Glu Arg Gln Asn Lys  Leu Glu Glu Ala Leu  Leu Phe Ser 
    4895                 4900                 4905             


Gly Gln  Phe Thr Asp Ala Leu  Gln Ala Leu Ile Asp  Trp Leu Tyr 
    4910                 4915                 4920             


Arg Val  Glu Pro Gln Leu Ala  Glu Asp Gln Pro Val  His Gly Asp 
    4925                 4930                 4935             


Ile Asp  Leu Val Met Asn Leu  Ile Asp Asn His Lys  Ala Phe Gln 
    4940                 4945                 4950             


Lys Glu  Leu Gly Lys Arg Thr  Ser Ser Val Gln Ala  Leu Lys Arg 
    4955                 4960                 4965             


Ser Ala  Arg Glu Leu Ile Glu  Gly Ser Arg Asp Asp  Ser Ser Trp 
    4970                 4975                 4980             


Val Lys  Val Gln Met Gln Glu  Leu Ser Thr Arg Trp  Glu Thr Val 
    4985                 4990                 4995             


Cys Ala  Leu Ser Ile Ser Lys  Gln Thr Arg Leu Glu  Ala Ala Leu 
    5000                 5005                 5010             


Arg Gln  Ala Glu Glu Phe His  Ser Val Val His Ala  Leu Leu Glu 
    5015                 5020                 5025             


Trp Leu  Ala Glu Ala Glu Gln  Thr Leu Arg Phe His  Gly Val Leu 
    5030                 5035                 5040             


Pro Asp  Asp Glu Asp Ala Leu  Arg Thr Leu Ile Asp  Gln His Lys 
    5045                 5050                 5055             


Glu Phe  Met Lys Lys Leu Glu  Glu Lys Arg Ala Glu  Leu Asn Lys 
    5060                 5065                 5070             


Ala Thr  Thr Met Gly Asp Thr  Val Leu Ala Ile Cys  His Pro Asp 
    5075                 5080                 5085             


Ser Ile  Thr Thr Ile Lys His  Trp Ile Thr Ile Ile  Arg Ala Arg 
    5090                 5095                 5100             


Phe Glu  Glu Val Leu Ala Trp  Ala Lys Gln His Gln  Gln Arg Leu 
    5105                 5110                 5115             


Ala Ser  Ala Leu Ala Gly Leu  Ile Ala Lys Gln Glu  Leu Leu Glu 
    5120                 5125                 5130             


Ala Leu  Leu Ala Trp Leu Gln  Trp Ala Glu Thr Thr  Leu Thr Asp 
    5135                 5140                 5145             


Lys Asp  Lys Glu Val Ile Pro  Gln Glu Ile Glu Glu  Val Lys Ala 
    5150                 5155                 5160             


Leu Ile  Ala Glu His Gln Thr  Phe Met Glu Glu Met  Thr Arg Lys 
    5165                 5170                 5175             


Gln Pro  Asp Val Asp Lys Val  Thr Lys Thr Tyr Lys  Arg Arg Ala 
    5180                 5185                 5190             


Ala Asp  Pro Ser Ser Leu Gln  Ser His Ile Pro Val  Leu Asp Lys 
    5195                 5200                 5205             


Gly Arg  Ala Gly Arg Lys Arg  Phe Pro Ala Ser Ser  Leu Tyr Pro 
    5210                 5215                 5220             


Ser Gly  Ser Gln Thr Gln Ile  Glu Thr Lys Asn Pro  Arg Val Asn 
    5225                 5230                 5235             


Leu Leu  Val Ser Lys Trp Gln  Gln Val Trp Leu Leu  Ala Leu Glu 
    5240                 5245                 5250             


Arg Arg  Arg Lys Leu Asn Asp  Ala Leu Asp Arg Leu  Glu Glu Leu 
    5255                 5260                 5265             


Arg Glu  Phe Ala Asn Phe Asp  Phe Asp Ile Trp Arg  Lys Lys Tyr 
    5270                 5275                 5280             


Met Arg  Trp Met Asn His Lys  Lys Ser Arg Val Met  Asp Phe Phe 
    5285                 5290                 5295             


Arg Arg  Ile Asp Lys Asp Gln  Asp Gly Lys Ile Thr  Arg Gln Glu 
    5300                 5305                 5310             


Phe Ile  Asp Gly Ile Leu Ser  Ser Lys Phe Pro Thr  Ser Arg Leu 
    5315                 5320                 5325             


Glu Met  Ser Ala Val Ala Asp  Ile Phe Asp Arg Asp  Gly Asp Gly 
    5330                 5335                 5340             


Tyr Ile  Asp Tyr Tyr Glu Phe  Val Ala Ala Leu His  Pro Asn Lys 
    5345                 5350                 5355             


Asp Ala  Tyr Lys Pro Ile Thr  Asp Ala Asp Lys Ile  Glu Asp Glu 
    5360                 5365                 5370             


Val Thr  Arg Gln Val Ala Lys  Cys Lys Cys Ala Lys  Arg Phe Gln 
    5375                 5380                 5385             


Val Glu  Gln Ile Gly Asp Asn  Lys Tyr Arg Phe Phe  Leu Gly Asn 
    5390                 5395                 5400             


Gln Phe  Gly Asp Ser Gln Gln  Leu Arg Leu Val Arg  Ile Leu Arg 
    5405                 5410                 5415             


Ser Thr  Val Met Val Arg Val  Gly Gly Gly Trp Met  Ala Leu Asp 
    5420                 5425                 5430             


Glu Phe  Leu Val Lys Asn Asp  Pro Cys Arg Ala Lys  Gly Arg Thr 
    5435                 5440                 5445             


Asn Met  Glu Leu Arg Glu Lys  Phe Ile Leu Ala Asp  Gly Ala Ser 
    5450                 5455                 5460             


Gln Gly  Met Ala Ala Phe Arg  Pro Arg Gly Arg Arg  Ser Arg Pro 
    5465                 5470                 5475             


Ser Ser  Arg Gly Ala Ser Pro  Asn Arg Ser Thr Ser  Val Ser Ser 
    5480                 5485                 5490             


Gln Ala  Ala Gln Ala Ala Ser  Pro Gln Val Pro Ala  Thr Thr Thr 
    5495                 5500                 5505             


Pro Lys  Ile Leu His Pro Leu  Thr Arg Asn Tyr Gly  Lys Pro Trp 
    5510                 5515                 5520             


Leu Thr  Asn Ser Lys Met Ser  Thr Pro Cys Lys Ala  Ala Glu Cys 
    5525                 5530                 5535             


Ser Asp  Phe Pro Val Pro Ser  Ala Glu Gly Thr Pro  Ile Gln Gly 
    5540                 5545                 5550             


Ser Lys  Leu Arg Leu Pro Gly  Tyr Leu Ser Gly Lys  Gly Phe His 
    5555                 5560                 5565             


Ser Gly  Glu Asp Ser Gly Leu  Ile Thr Thr Ala Ala  Ala Arg Val 
    5570                 5575                 5580             


Arg Thr  Gln Phe Ala Asp Ser  Lys Lys Thr Pro Ser  Arg Pro Gly 
    5585                 5590                 5595             


Ser Arg  Ala Gly Ser Lys Ala  Gly Ser Arg Ala Ser  Ser Arg Arg 
    5600                 5605                 5610             


Gly Ser  Asp Ala Ser Asp Phe  Asp Ile Ser Glu Ile  Gln Ser Val 
    5615                 5620                 5625             


Cys Ser  Asp Val Glu Thr Val  Pro Gln Thr His Arg  Pro Thr Pro 
    5630                 5635                 5640             


Arg Ala  Gly Ser Arg Pro Ser  Thr Ala Lys Pro Ser  Lys Ile Pro 
    5645                 5650                 5655             


Thr Pro  Gln Arg Lys Ser Pro  Ala Ser Lys Leu Asp  Lys Ser Ser 
    5660                 5665                 5670             


Lys Arg  
    5675 


<210>  4643
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  4643

Met Ala Ser Leu Gly Leu Gln Leu Val Gly Tyr Ile Leu Gly Leu Leu 
1               5                   10                  15      


Gly Leu Leu Gly Thr Leu Val Ala Met Leu Leu Pro Ser Trp Lys Thr 
            20                  25                  30          


Ser Ser Tyr Val Gly Ala Ser Ile Val Thr Ala Val Gly Phe Ser Lys 
        35                  40                  45              


Gly Leu Trp Met Glu Cys Ala Thr His Ser Thr Gly Ile Thr Gln Cys 
    50                  55                  60                  


Asp Ile Tyr Ser Thr Leu Leu Gly Leu Pro Ala Asp Ile Gln Ala Ala 
65                  70                  75                  80  


Gln Ala Met Met Val Thr Ser Ser Ala Ile Ser Ser Leu Ala Cys Ile 
                85                  90                  95      


Ile Ser Val Val Gly Met Arg Cys Thr Val Phe Cys Gln Glu Ser Arg 
            100                 105                 110         


Ala Lys Asp Arg Val Ala Val Ala Gly Gly Val Phe Phe Ile Leu Gly 
        115                 120                 125             


Gly Leu Leu Gly Phe Ile Pro Val Ala Trp Asn Leu His Gly Ile Leu 
    130                 135                 140                 


Arg Asp Phe Tyr Ser Pro Leu Val Pro Asp Ser Met Lys Phe Glu Ile 
145                 150                 155                 160 


Gly Glu Ala Leu Tyr Leu Gly Ile Ile Ser Ser Leu Phe Ser Leu Ile 
                165                 170                 175     


Ala Gly Ile Ile Leu Cys Phe Ser Cys Ser Ser Gln Arg Asn Arg Ser 
            180                 185                 190         


Asn Tyr Tyr Asp Ala Tyr Gln Ala Gln Pro Leu Ala Thr Arg Ser Ser 
        195                 200                 205             


Pro Arg Pro Gly Gln Pro Pro Lys Val Lys Ser Glu Phe Asn Ser Tyr 
    210                 215                 220                 


Ser Leu Thr Gly Tyr Val 
225                 230 


<210>  4644
<211>  862
<212>  PRT
<213>  Homo sapiens

<400>  4644

Met Leu Arg Asn Ser Thr Phe Lys Asn Met Gln Arg Arg His Thr Thr 
1               5                   10                  15      


Leu Arg Glu Lys Gly Arg Arg Gln Ala Ile Arg Gly Pro Ala Tyr Met 
            20                  25                  30          


Phe Asn Glu Lys Gly Thr Ser Leu Thr Pro Glu Glu Glu Arg Phe Leu 
        35                  40                  45              


Asp Ser Ala Glu Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu Glu 
    50                  55                  60                  


Glu Ser Lys Thr Leu Asn Phe Asn Cys Val Asp Tyr Met Gly Gln Asn 
65                  70                  75                  80  


Ala Leu Gln Leu Ala Val Gly Asn Glu His Leu Glu Val Thr Glu Leu 
                85                  90                  95      


Leu Leu Lys Lys Glu Asn Leu Ala Arg Val Gly Asp Ala Leu Leu Leu 
            100                 105                 110         


Ala Ile Ser Lys Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Asn His 
        115                 120                 125             


Pro Ala Phe Ala Gln Gly Gln Arg Leu Thr Leu Ser Pro Leu Glu Gln 
    130                 135                 140                 


Glu Leu Arg Asp Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr Arg 
145                 150                 155                 160 


Phe Ser His Asp Ile Thr Pro Ile Ile Leu Ala Ala His Cys Gln Glu 
                165                 170                 175     


Tyr Glu Ile Val His Ile Leu Leu Leu Lys Gly Ala Arg Ile Glu Arg 
            180                 185                 190         


Pro His Asp Tyr Phe Cys Lys Cys Asn Glu Cys Thr Glu Lys Gln Arg 
        195                 200                 205             


Lys Asp Ser Phe Ser His Ser Arg Ser Arg Met Asn Ala Tyr Lys Gly 
    210                 215                 220                 


Leu Ala Ser Ala Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val Leu 
225                 230                 235                 240 


Thr Ala Leu Glu Leu Ser Asn Glu Leu Ala Arg Leu Ala Asn Ile Glu 
                245                 250                 255     


Thr Glu Phe Lys Asn Asp Tyr Arg Lys Leu Ser Met Gln Cys Lys Asp 
            260                 265                 270         


Phe Val Val Gly Val Leu Asp Leu Cys Arg Asp Thr Glu Glu Val Glu 
        275                 280                 285             


Ala Ile Leu Asn Gly Asp Val Asn Phe Gln Val Trp Ser Asp His His 
    290                 295                 300                 


Arg Pro Ser Leu Ser Arg Ile Lys Leu Ala Ile Lys Tyr Glu Val Lys 
305                 310                 315                 320 


Lys Phe Val Ala His Pro Asn Cys Gln Gln Gln Leu Leu Thr Met Trp 
                325                 330                 335     


Tyr Glu Asn Leu Ser Gly Leu Arg Gln Gln Ser Ile Ala Val Lys Phe 
            340                 345                 350         


Leu Ala Val Phe Gly Val Ser Ile Gly Leu Pro Phe Leu Ala Ile Ala 
        355                 360                 365             


Tyr Trp Ile Ala Pro Cys Ser Lys Leu Gly Arg Thr Leu Arg Ser Pro 
    370                 375                 380                 


Phe Met Lys Phe Val Ala His Ala Val Ser Phe Thr Ile Phe Leu Gly 
385                 390                 395                 400 


Leu Leu Val Val Asn Ala Ser Asp Arg Phe Glu Gly Val Lys Thr Leu 
                405                 410                 415     


Pro Asn Glu Thr Phe Thr Asp Tyr Pro Lys Gln Ile Phe Arg Val Lys 
            420                 425                 430         


Thr Thr Gln Phe Ser Trp Thr Glu Met Leu Ile Met Lys Trp Val Leu 
        435                 440                 445             


Gly Met Ile Trp Ser Glu Cys Lys Glu Ile Trp Glu Glu Gly Pro Arg 
    450                 455                 460                 


Glu Tyr Val Leu His Leu Trp Asn Leu Leu Asp Phe Gly Met Leu Ser 
465                 470                 475                 480 


Ile Phe Val Ala Ser Phe Thr Ala Arg Phe Met Ala Phe Leu Lys Ala 
                485                 490                 495     


Thr Glu Ala Gln Leu Tyr Val Asp Gln His Val Gln Asp Asp Thr Leu 
            500                 505                 510         


His Asn Val Ser Leu Pro Pro Glu Val Ala Tyr Phe Thr Tyr Ala Arg 
        515                 520                 525             


Asp Lys Trp Trp Pro Ser Asp Pro Gln Ile Ile Ser Glu Gly Leu Tyr 
    530                 535                 540                 


Ala Ile Ala Val Val Leu Ser Phe Ser Arg Ile Ala Tyr Ile Leu Pro 
545                 550                 555                 560 


Ala Asn Glu Ser Phe Gly Pro Leu Gln Ile Ser Leu Gly Arg Thr Val 
                565                 570                 575     


Lys Asp Ile Phe Lys Phe Met Val Ile Phe Ile Met Val Phe Val Ala 
            580                 585                 590         


Phe Met Ile Gly Met Phe Asn Leu Tyr Ser Tyr Tyr Arg Gly Ala Lys 
        595                 600                 605             


Tyr Asn Pro Ala Phe Thr Thr Val Glu Glu Ser Phe Lys Thr Leu Phe 
    610                 615                 620                 


Trp Ser Ile Phe Gly Leu Ser Glu Val Ile Ser Val Val Leu Lys Tyr 
625                 630                 635                 640 


Asp His Lys Phe Ile Glu Asn Ile Gly Tyr Val Leu Tyr Gly Val Tyr 
                645                 650                 655     


Asn Val Thr Met Val Val Val Leu Leu Asn Met Leu Ile Ala Met Ile 
            660                 665                 670         


Asn Asn Ser Tyr Gln Glu Ile Glu Glu Asp Ala Asp Val Glu Trp Lys 
        675                 680                 685             


Phe Ala Arg Ala Lys Leu Trp Leu Ser Tyr Phe Asp Glu Gly Arg Thr 
    690                 695                 700                 


Leu Pro Ala Pro Phe Asn Leu Val Pro Ser Pro Lys Ser Phe Tyr Tyr 
705                 710                 715                 720 


Leu Ile Met Arg Ile Lys Met Cys Leu Ile Lys Leu Cys Lys Ser Lys 
                725                 730                 735     


Ala Lys Ser Cys Glu Asn Asp Leu Glu Met Gly Met Leu Asn Ser Lys 
            740                 745                 750         


Phe Lys Lys Thr Arg Tyr Gln Ala Gly Met Arg Asn Ser Glu Asn Leu 
        755                 760                 765             


Thr Ala Asn Asn Thr Leu Ser Lys Pro Thr Arg Tyr Gln Lys Ile Met 
    770                 775                 780                 


Lys Arg Leu Ile Lys Arg Tyr Val Leu Lys Ala Gln Val Asp Arg Glu 
785                 790                 795                 800 


Asn Asp Glu Val Asn Glu Gly Glu Leu Lys Glu Ile Lys Gln Asp Ile 
                805                 810                 815     


Ser Ser Leu Arg Tyr Glu Leu Leu Glu Glu Lys Ser Gln Ala Thr Gly 
            820                 825                 830         


Glu Leu Ala Asp Leu Ile Gln Gln Leu Ser Glu Lys Phe Gly Lys Asn 
        835                 840                 845             


Leu Asn Lys Asp His Leu Arg Val Asn Lys Gly Lys Asp Ile 
    850                 855                 860         


<210>  4645
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  4645

Met Val Asp Gln Leu Arg Glu Arg Thr Thr Met Ala Asp Pro Leu Arg 
1               5                   10                  15      


Glu Arg Thr Glu Leu Leu Leu Ala Asp Tyr Leu Gly Tyr Cys Ala Arg 
            20                  25                  30          


Glu Pro Gly Thr Pro Glu Pro Ala Pro Ser Thr Pro Glu Ala Ala Val 
        35                  40                  45              


Leu Arg Ser Ala Ala Ala Arg Leu Arg Gln Ile His Arg Ser Phe Phe 
    50                  55                  60                  


Ser Ala Tyr Leu Gly Tyr Pro Gly Asn Arg Phe Glu Leu Val Ala Leu 
65                  70                  75                  80  


Met Ala Asp Ser Val Leu Ser Asp Ser Pro Gly Pro Thr Trp Gly Arg 
                85                  90                  95      


Val Val Thr Leu Val Thr Phe Ala Gly Thr Leu Leu Glu Arg Gly Pro 
            100                 105                 110         


Leu Val Thr Ala Arg Trp Lys Lys Trp Gly Phe Gln Pro Arg Leu Lys 
        115                 120                 125             


Glu Gln Glu Gly Asp Val Ala Arg Asp Cys Gln Arg Leu Val Ala Leu 
    130                 135                 140                 


Leu Ser Ser Arg Leu Met Gly Gln His Arg Ala Trp Leu Gln Ala Gln 
145                 150                 155                 160 


Gly Gly Trp Asp Gly Phe Cys His Phe Phe Arg Thr Pro Phe Pro Leu 
                165                 170                 175     


Ala Phe Trp Arg Lys Gln Leu Val Gln Ala Phe Leu Ser Cys Leu Leu 
            180                 185                 190         


Thr Thr Ala Phe Ile Tyr Leu Trp Thr Arg Leu Leu 
        195                 200                 


<210>  4646
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  4646

Met Leu Ala Asn Ser Ser Ser Thr Asn Ser Ser Val Leu Pro Cys Pro 
1               5                   10                  15      


Asp Tyr Arg Pro Thr His Arg Leu His Leu Val Val Tyr Ser Leu Val 
            20                  25                  30          


Leu Ala Ala Gly Leu Pro Leu Asn Ala Leu Ala Leu Trp Val Phe Leu 
        35                  40                  45              


Arg Ala Leu Arg Val His Ser Val Val Ser Val Tyr Met Cys Asn Leu 
    50                  55                  60                  


Ala Ala Ser Asp Leu Leu Phe Thr Leu Ser Leu Pro Val Arg Leu Ser 
65                  70                  75                  80  


Tyr Tyr Ala Leu His His Trp Pro Phe Pro Asp Leu Leu Cys Gln Thr 
                85                  90                  95      


Thr Gly Ala Ile Phe Gln Met Asn Met Tyr Gly Ser Cys Ile Phe Leu 
            100                 105                 110         


Met Leu Ile Asn Val Asp Arg Tyr Ala Ala Ile Val His Pro Leu Arg 
        115                 120                 125             


Leu Arg His Leu Arg Arg Pro Arg Val Ala Arg Leu Leu Cys Leu Gly 
    130                 135                 140                 


Val Trp Ala Leu Ile Leu Val Phe Ala Val Pro Ala Ala Arg Val His 
145                 150                 155                 160 


Arg Pro Ser Arg Cys Arg Tyr Arg Asp Leu Glu Val Arg Leu Cys Phe 
                165                 170                 175     


Glu Ser Phe Ser Asp Glu Leu Trp Lys Gly Arg Leu Leu Pro Leu Val 
            180                 185                 190         


Leu Leu Ala Glu Ala Leu Gly Phe Leu Leu Pro Leu Ala Ala Val Val 
        195                 200                 205             


Tyr Ser Ser Gly Arg Val Phe Trp Thr Leu Ala Arg Pro Asp Ala Thr 
    210                 215                 220                 


Gln Ser Gln Arg Arg Arg Lys Thr Val Arg Leu Leu Leu Ala Asn Leu 
225                 230                 235                 240 


Val Ile Phe Leu Leu Cys Phe Val Pro Tyr Asn Ser Thr Leu Ala Val 
                245                 250                 255     


Tyr Gly Leu Leu Arg Ser Lys Leu Val Ala Ala Ser Val Pro Ala Arg 
            260                 265                 270         


Asp Arg Val Arg Gly Val Leu Met Val Met Val Leu Leu Ala Gly Ala 
        275                 280                 285             


Asn Cys Val Leu Asp Pro Leu Val Tyr Tyr Phe Ser Ala Glu Gly Phe 
    290                 295                 300                 


Arg Asn Thr Leu Arg Gly Leu Gly Thr Pro His Arg Ala Arg Thr Ser 
305                 310                 315                 320 


Ala Thr Asn Gly Thr Arg Ala Ala Leu Ala Gln Ser Glu Arg Ser Ala 
                325                 330                 335     


Val Thr Thr Asp Ala Thr Arg Pro Asp Ala Ala Ser Gln Gly Leu Leu 
            340                 345                 350         


Arg Pro Ser Asp Ser His Ser Leu Ser Ser Phe Thr Gln Cys Pro Gln 
        355                 360                 365             


Asp Ser Ala Leu 
    370         


<210>  4647
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  4647

Met Gly Leu Arg Ser His His Leu Ser Leu Gly Leu Leu Leu Leu Phe 
1               5                   10                  15      


Leu Leu Pro Ala Glu Cys Leu Gly Ala Glu Gly Arg Leu Ala Leu Lys 
            20                  25                  30          


Leu Phe Arg Asp Leu Phe Ala Asn Tyr Thr Ser Ala Leu Arg Pro Val 
        35                  40                  45              


Ala Asp Thr Asp Gln Thr Leu Asn Val Thr Leu Glu Val Thr Leu Ser 
    50                  55                  60                  


Gln Ile Ile Asp Met Asp Glu Arg Asn Gln Val Leu Thr Leu Tyr Leu 
65                  70                  75                  80  


Trp Ile Arg Gln Glu Trp Thr Asp Ala Tyr Leu Arg Trp Asp Pro Asn 
                85                  90                  95      


Ala Tyr Gly Gly Leu Asp Ala Ile Arg Ile Pro Ser Ser Leu Val Trp 
            100                 105                 110         


Arg Pro Asp Ile Val Leu Tyr Asn Lys Ala Asp Ala Gln Pro Pro Gly 
        115                 120                 125             


Ser Ala Ser Thr Asn Val Val Leu Arg His Asp Gly Ala Val Arg Trp 
    130                 135                 140                 


Asp Ala Pro Ala Ile Thr Arg Ser Ser Cys Arg Val Asp Val Ala Ala 
145                 150                 155                 160 


Phe Pro Phe Asp Ala Gln His Cys Gly Leu Thr Phe Gly Ser Trp Thr 
                165                 170                 175     


His Gly Gly His Gln Leu Asp Val Arg Pro Arg Gly Ala Ala Ala Ser 
            180                 185                 190         


Leu Ala Asp Phe Val Glu Asn Val Glu Trp Arg Val Leu Gly Met Pro 
        195                 200                 205             


Ala Arg Arg Arg Val Leu Thr Tyr Gly Cys Cys Ser Glu Pro Tyr Pro 
    210                 215                 220                 


Asp Val Thr Phe Thr Leu Leu Leu Arg Arg Arg Ala Ala Ala Tyr Val 
225                 230                 235                 240 


Cys Asn Leu Leu Leu Pro Cys Val Leu Ile Ser Leu Leu Ala Pro Leu 
                245                 250                 255     


Ala Phe His Leu Pro Ala Asp Ser Gly Glu Lys Val Ser Leu Gly Val 
            260                 265                 270         


Thr Val Leu Leu Ala Leu Thr Val Phe Gln Leu Leu Leu Ala Glu Ser 
        275                 280                 285             


Met Pro Pro Ala Glu Ser Val Pro Leu Ile Gly Lys Tyr Tyr Met Ala 
    290                 295                 300                 


Thr Met Thr Met Val Thr Phe Ser Thr Ala Leu Thr Ile Leu Ile Met 
305                 310                 315                 320 


Asn Leu His Tyr Cys Gly Pro Ser Val Arg Pro Val Pro Ala Trp Ala 
                325                 330                 335     


Arg Ala Leu Leu Leu Gly His Leu Ala Arg Gly Leu Cys Val Arg Glu 
            340                 345                 350         


Arg Gly Glu Pro Cys Gly Gln Ser Arg Pro Pro Glu Leu Ser Pro Ser 
        355                 360                 365             


Pro Gln Ser Pro Glu Gly Gly Ala Gly Pro Pro Ala Gly Pro Cys His 
    370                 375                 380                 


Glu Pro Arg Cys Leu Cys Arg Gln Glu Ala Leu Leu His His Val Ala 
385                 390                 395                 400 


Thr Ile Ala Asn Thr Phe Arg Ser His Arg Ala Ala Gln Arg Cys His 
                405                 410                 415     


Glu Asp Trp Lys Arg Leu Ala Arg Val Met Asp Arg Phe Phe Leu Ala 
            420                 425                 430         


Ile Phe Phe Ser Met Ala Leu Val Met Ser Leu Leu Val Leu Val Gln 
        435                 440                 445             


Ala Leu 
    450 


<210>  4648
<211>  1203
<212>  PRT
<213>  Homo sapiens

<400>  4648

Met Asp Leu Arg Asp Phe Tyr Leu Leu Ala Ala Leu Ile Ala Cys Leu 
1               5                   10                  15      


Arg Leu Asp Ser Ala Ile Ala Gln Glu Leu Ile Tyr Thr Ile Arg Glu 
            20                  25                  30          


Glu Leu Pro Glu Asn Val Pro Ile Gly Asn Ile Pro Lys Asp Leu Asn 
        35                  40                  45              


Ile Ser His Ile Asn Ala Ala Thr Gly Thr Ser Ala Ser Leu Val Tyr 
    50                  55                  60                  


Arg Leu Val Ser Lys Ala Gly Asp Ala Pro Leu Val Lys Val Ser Ser 
65                  70                  75                  80  


Ser Thr Gly Glu Ile Phe Thr Thr Ser Asn Arg Ile Asp Arg Glu Lys 
                85                  90                  95      


Leu Cys Ala Gly Ala Ser Tyr Ala Glu Glu Asn Glu Cys Phe Phe Glu 
            100                 105                 110         


Leu Glu Val Val Ile Leu Pro Asn Asp Phe Phe Arg Leu Ile Lys Ile 
        115                 120                 125             


Lys Ile Ile Val Lys Asp Thr Asn Asp Asn Ala Pro Met Phe Pro Ser 
    130                 135                 140                 


Pro Val Ile Asn Ile Ser Ile Pro Glu Asn Thr Leu Ile Asn Ser Arg 
145                 150                 155                 160 


Phe Pro Ile Pro Ser Ala Thr Asp Pro Asp Thr Gly Phe Asn Gly Val 
                165                 170                 175     


Gln His Tyr Glu Leu Leu Asn Gly Gln Ser Val Phe Gly Leu Asp Ile 
            180                 185                 190         


Val Glu Thr Pro Glu Gly Glu Lys Trp Pro Gln Leu Ile Val Gln Gln 
        195                 200                 205             


Asn Leu Asp Arg Glu Gln Lys Asp Thr Tyr Val Met Lys Ile Lys Val 
    210                 215                 220                 


Glu Asp Gly Gly Thr Pro Gln Lys Ser Ser Thr Ala Ile Leu Gln Val 
225                 230                 235                 240 


Thr Val Ser Asp Val Asn Asp Asn Arg Pro Val Phe Lys Glu Gly Gln 
                245                 250                 255     


Val Glu Val His Ile Pro Glu Asn Ala Pro Val Gly Thr Ser Val Ile 
            260                 265                 270         


Gln Leu His Ala Thr Asp Ala Asp Ile Gly Ser Asn Ala Glu Ile Arg 
        275                 280                 285             


Tyr Ile Phe Gly Ala Gln Val Ala Pro Ala Thr Lys Arg Leu Phe Ala 
    290                 295                 300                 


Leu Asn Asn Thr Thr Gly Leu Ile Thr Val Gln Arg Ser Leu Asp Arg 
305                 310                 315                 320 


Glu Glu Thr Ala Ile His Lys Val Thr Val Leu Ala Ser Asp Gly Ser 
                325                 330                 335     


Ser Thr Pro Ala Arg Ala Thr Val Thr Ile Asn Val Thr Asp Val Asn 
            340                 345                 350         


Asp Asn Pro Pro Asn Ile Asp Leu Arg Tyr Ile Ile Ser Pro Ile Asn 
        355                 360                 365             


Gly Thr Val Tyr Leu Ser Glu Lys Asp Pro Val Asn Thr Lys Ile Ala 
    370                 375                 380                 


Leu Ile Thr Val Ser Asp Lys Asp Thr Asp Val Asn Gly Lys Val Ile 
385                 390                 395                 400 


Cys Phe Ile Glu Arg Glu Val Pro Phe His Leu Lys Ala Val Tyr Asp 
                405                 410                 415     


Asn Gln Tyr Leu Leu Glu Thr Ser Ser Leu Leu Asp Tyr Glu Gly Thr 
            420                 425                 430         


Lys Glu Phe Ser Phe Lys Ile Val Ala Ser Asp Ser Gly Lys Pro Ser 
        435                 440                 445             


Leu Asn Gln Thr Ala Leu Val Arg Val Lys Leu Glu Asp Glu Asn Asp 
    450                 455                 460                 


Asn Pro Pro Ile Phe Asn Gln Pro Val Ile Glu Leu Ser Val Ser Glu 
465                 470                 475                 480 


Asn Asn Arg Arg Gly Leu Tyr Leu Thr Thr Ile Ser Ala Thr Asp Glu 
                485                 490                 495     


Asp Ser Gly Lys Asn Ala Asp Ile Val Tyr Gln Leu Gly Pro Asn Ala 
            500                 505                 510         


Ser Phe Phe Asp Leu Asp Arg Lys Thr Gly Val Leu Thr Ala Ser Arg 
        515                 520                 525             


Val Phe Asp Arg Glu Glu Gln Glu Arg Phe Ile Phe Thr Val Thr Ala 
    530                 535                 540                 


Arg Asp Asn Gly Thr Pro Pro Leu Gln Ser Gln Ala Ala Val Ile Val 
545                 550                 555                 560 


Thr Val Leu Asp Glu Asn Asp Asn Ser Pro Lys Phe Thr His Asn His 
                565                 570                 575     


Phe Gln Phe Phe Val Ser Glu Asn Leu Pro Lys Tyr Ser Thr Val Gly 
            580                 585                 590         


Val Ile Thr Val Thr Asp Ala Asp Ala Gly Glu Asn Lys Ala Val Thr 
        595                 600                 605             


Leu Ser Ile Leu Asn Asp Asn Asp Asn Phe Val Leu Asp Pro Tyr Ser 
    610                 615                 620                 


Gly Val Ile Lys Ser Asn Val Ser Phe Asp Arg Glu Gln Gln Ser Ser 
625                 630                 635                 640 


Tyr Thr Phe Asp Val Lys Ala Thr Asp Gly Gly Gln Pro Pro Arg Ser 
                645                 650                 655     


Ser Thr Ala Lys Val Thr Ile Asn Val Met Asp Val Asn Asp Asn Ser 
            660                 665                 670         


Pro Val Val Ile Ser Pro Pro Ser Asn Thr Ser Phe Lys Leu Val Pro 
        675                 680                 685             


Leu Ser Ala Ile Pro Gly Ser Val Val Ala Glu Val Phe Ala Val Asp 
    690                 695                 700                 


Val Asp Thr Gly Met Asn Ala Glu Leu Lys Tyr Thr Ile Val Ser Gly 
705                 710                 715                 720 


Asn Asn Lys Gly Leu Phe Arg Ile Asp Pro Val Thr Gly Asn Ile Thr 
                725                 730                 735     


Leu Glu Glu Lys Pro Ala Pro Thr Asp Val Gly Leu His Arg Leu Val 
            740                 745                 750         


Val Asn Ile Ser Asp Leu Gly Tyr Pro Lys Ser Leu His Thr Leu Val 
        755                 760                 765             


Leu Val Phe Leu Tyr Val Asn Asp Thr Ala Gly Asn Ala Ser Tyr Ile 
    770                 775                 780                 


Tyr Asp Leu Ile Arg Arg Thr Met Glu Thr Pro Leu Asp Arg Asn Ile 
785                 790                 795                 800 


Gly Asp Ser Ser Gln Pro Tyr Gln Asn Glu Asp Tyr Leu Thr Ile Met 
                805                 810                 815     


Ile Ala Ile Ile Ala Gly Ala Met Val Val Ile Val Val Ile Phe Val 
            820                 825                 830         


Thr Val Leu Val Arg Cys Arg His Ala Ser Arg Phe Lys Ala Ala Gln 
        835                 840                 845             


Arg Ser Lys Gln Gly Ala Glu Trp Met Ser Pro Asn Gln Glu Asn Lys 
    850                 855                 860                 


Gln Asn Lys Lys Lys Lys Arg Lys Lys Arg Lys Ser Pro Lys Ser Ser 
865                 870                 875                 880 


Leu Leu Asn Phe Val Thr Ile Glu Glu Ser Lys Pro Asp Asp Ala Val 
                885                 890                 895     


His Glu Pro Ile Asn Gly Thr Ile Ser Leu Pro Ala Glu Leu Glu Glu 
            900                 905                 910         


Gln Ser Ile Gly Arg Phe Asp Trp Gly Pro Ala Pro Pro Thr Thr Phe 
        915                 920                 925             


Lys Pro Asn Ser Pro Asp Leu Ala Lys His Tyr Lys Ser Ala Ser Pro 
    930                 935                 940                 


Gln Pro Ala Phe His Leu Lys Pro Asp Thr Pro Val Ser Val Lys Lys 
945                 950                 955                 960 


His His Val Ile Gln Glu Leu Pro Leu Asp Asn Thr Phe Val Gly Gly 
                965                 970                 975     


Cys Asp Thr Leu Ser Lys Arg Ser Ser Thr Ser Ser Asp His Phe Ser 
            980                 985                 990         


Ala Ser Glu Cys Ser Ser Gln Gly  Gly Phe Lys Thr Lys  Gly Pro Leu 
        995                 1000                 1005             


His Thr  Arg Gln Ser Gln Arg  Arg Val Thr Phe His  Leu Pro Asp 
    1010                 1015                 1020             


Gly Ser  Gln Glu Ser Cys Ser  Asp Ser Gly Leu Gly  Asp His Glu 
    1025                 1030                 1035             


Pro Val  Gly Ser Gly Thr Leu  Ile Ser His Pro Leu  Pro Leu Val 
    1040                 1045                 1050             


Gln Pro  Gln Asp Glu Phe Tyr  Asp Gln Ala Ser Pro  Asp Lys Arg 
    1055                 1060                 1065             


Thr Glu  Ala Asp Gly Asn Ser  Asp Pro Asn Ser Asp  Gly Pro Leu 
    1070                 1075                 1080             


Gly Pro  Arg Gly Leu Ala Glu  Ala Thr Glu Met Cys  Thr Gln Glu 
    1085                 1090                 1095             


Cys Leu  Val Leu Gly His Ser  Asp Asn Cys Trp Met  Pro Pro Gly 
    1100                 1105                 1110             


Leu Gly  Pro Tyr Gln His Pro  Lys Ser Pro Leu Ser  Thr Phe Ala 
    1115                 1120                 1125             


Pro Gln  Lys Glu Trp Val Lys  Lys Asp Lys Leu Val  Asn Gly His 
    1130                 1135                 1140             


Thr Leu  Thr Arg Ala Trp Lys  Glu Asp Ser Asn Arg  Asn Gln Phe 
    1145                 1150                 1155             


Asn Asp  Arg Lys Gln Tyr Gly  Ser Asn Glu Gly His  Phe Asn Asn 
    1160                 1165                 1170             


Gly Ser  His Met Thr Asp Ile  Pro Leu Ala Asn Leu  Lys Ser Tyr 
    1175                 1180                 1185             


Lys Gln  Ala Gly Gly Ala Thr  Glu Ser Pro Lys Glu  His Gln Leu 
    1190                 1195                 1200             


<210>  4649
<211>  757
<212>  PRT
<213>  Homo sapiens

<400>  4649

Met Leu Leu Arg Leu Leu Leu Ala Trp Ala Ala Ala Gly Pro Thr Leu 
1               5                   10                  15      


Gly Gln Asp Pro Trp Ala Ala Glu Pro Arg Ala Ala Cys Gly Pro Ser 
            20                  25                  30          


Ser Cys Tyr Ala Leu Phe Pro Arg Arg Arg Thr Phe Leu Glu Ala Trp 
        35                  40                  45              


Arg Ala Cys Arg Glu Leu Gly Gly Asp Leu Ala Thr Pro Arg Thr Pro 
    50                  55                  60                  


Glu Glu Ala Gln Arg Val Asp Ser Leu Val Gly Ala Gly Pro Ala Ser 
65                  70                  75                  80  


Arg Leu Leu Trp Ile Gly Leu Gln Arg Gln Ala Arg Gln Cys Gln Leu 
                85                  90                  95      


Gln Arg Pro Leu Arg Gly Phe Thr Trp Thr Thr Gly Asp Gln Asp Thr 
            100                 105                 110         


Ala Phe Thr Asn Trp Ala Gln Pro Ala Ser Gly Gly Pro Cys Pro Ala 
        115                 120                 125             


Gln Arg Cys Val Ala Leu Glu Ala Ser Gly Glu His Arg Trp Leu Glu 
    130                 135                 140                 


Gly Ser Cys Thr Leu Ala Val Asp Gly Tyr Leu Cys Gln Phe Gly Phe 
145                 150                 155                 160 


Glu Gly Ala Cys Pro Ala Leu Gln Asp Glu Ala Gly Gln Ala Gly Pro 
                165                 170                 175     


Ala Val Tyr Thr Thr Pro Phe His Leu Val Ser Thr Glu Phe Glu Trp 
            180                 185                 190         


Leu Pro Phe Gly Ser Val Ala Ala Val Gln Cys Gln Ala Gly Arg Gly 
        195                 200                 205             


Ala Ser Leu Leu Cys Val Lys Gln Pro Glu Gly Gly Val Gly Trp Ser 
    210                 215                 220                 


Arg Ala Gly Pro Leu Cys Leu Gly Thr Gly Cys Ser Pro Asp Asn Gly 
225                 230                 235                 240 


Gly Cys Glu His Glu Cys Val Glu Glu Val Asp Gly His Val Ser Cys 
                245                 250                 255     


Arg Cys Thr Glu Gly Phe Arg Leu Ala Ala Asp Gly Arg Ser Cys Glu 
            260                 265                 270         


Asp Pro Cys Ala Gln Ala Pro Cys Glu Gln Gln Cys Glu Pro Gly Gly 
        275                 280                 285             


Pro Gln Gly Tyr Ser Cys His Cys Arg Leu Gly Phe Arg Pro Ala Glu 
    290                 295                 300                 


Asp Asp Pro His Arg Cys Val Asp Thr Asp Glu Cys Gln Ile Ala Gly 
305                 310                 315                 320 


Val Cys Gln Gln Met Cys Val Asn Tyr Val Gly Gly Phe Glu Cys Tyr 
                325                 330                 335     


Cys Ser Glu Gly His Glu Leu Glu Ala Asp Gly Ile Ser Cys Ser Pro 
            340                 345                 350         


Ala Gly Ala Met Gly Ala Gln Ala Ser Gln Asp Leu Gly Asp Glu Leu 
        355                 360                 365             


Leu Asp Asp Gly Glu Asp Glu Glu Asp Glu Asp Glu Ala Trp Lys Ala 
    370                 375                 380                 


Phe Asn Gly Gly Trp Thr Glu Met Pro Gly Ile Leu Trp Met Glu Pro 
385                 390                 395                 400 


Thr Gln Pro Pro Asp Phe Ala Leu Ala Tyr Arg Pro Ser Phe Pro Glu 
                405                 410                 415     


Asp Arg Glu Pro Gln Ile Pro Tyr Pro Glu Pro Thr Trp Pro Pro Pro 
            420                 425                 430         


Leu Ser Ala Pro Arg Val Pro Tyr His Ser Ser Val Leu Ser Val Thr 
        435                 440                 445             


Arg Pro Val Val Val Ser Ala Thr His Pro Thr Leu Pro Ser Ala His 
    450                 455                 460                 


Gln Pro Pro Val Ile Pro Ala Thr His Pro Ala Leu Ser Arg Asp His 
465                 470                 475                 480 


Gln Ile Pro Val Ile Ala Ala Asn Tyr Pro Asp Leu Pro Ser Ala Tyr 
                485                 490                 495     


Gln Pro Gly Ile Leu Ser Val Ser His Ser Ala Gln Pro Pro Ala His 
            500                 505                 510         


Gln Pro Pro Met Ile Ser Thr Lys Tyr Pro Glu Leu Phe Pro Ala His 
        515                 520                 525             


Gln Ser Pro Met Phe Pro Asp Thr Arg Val Ala Gly Thr Gln Thr Thr 
    530                 535                 540                 


Thr His Leu Pro Gly Ile Pro Pro Asn His Ala Pro Leu Val Thr Thr 
545                 550                 555                 560 


Leu Gly Ala Gln Leu Pro Pro Gln Ala Pro Asp Ala Leu Val Leu Arg 
                565                 570                 575     


Thr Gln Ala Thr Gln Leu Pro Ile Ile Pro Thr Ala Gln Pro Ser Leu 
            580                 585                 590         


Thr Thr Thr Ser Arg Ser Pro Val Ser Pro Ala His Gln Ile Ser Val 
        595                 600                 605             


Pro Ala Ala Thr Gln Pro Ala Ala Leu Pro Thr Leu Leu Pro Ser Gln 
    610                 615                 620                 


Ser Pro Thr Asn Gln Thr Ser Pro Ile Ser Pro Thr His Pro His Ser 
625                 630                 635                 640 


Lys Ala Pro Gln Ile Pro Arg Glu Asp Gly Pro Ser Pro Lys Leu Ala 
                645                 650                 655     


Leu Trp Leu Pro Ser Pro Ala Pro Thr Ala Ala Pro Thr Ala Leu Gly 
            660                 665                 670         


Glu Ala Gly Leu Ala Glu His Ser Gln Arg Asp Asp Arg Trp Leu Leu 
        675                 680                 685             


Val Ala Leu Leu Val Pro Thr Cys Val Phe Leu Val Val Leu Leu Ala 
    690                 695                 700                 


Leu Gly Ile Val Tyr Cys Thr Arg Cys Gly Pro His Ala Pro Asn Lys 
705                 710                 715                 720 


Arg Ile Thr Asp Cys Tyr Arg Trp Val Ile His Ala Gly Ser Lys Ser 
                725                 730                 735     


Pro Thr Glu Pro Met Pro Pro Arg Gly Ser Leu Thr Gly Val Gln Thr 
            740                 745                 750         


Cys Arg Thr Ser Val 
        755         


<210>  4650
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  4650

Met Arg Gly Glu Leu Trp Leu Leu Val Leu Val Leu Arg Glu Ala Ala 
1               5                   10                  15      


Arg Ala Leu Ser Pro Gln Pro Gly Ala Gly His Asp Glu Gly Pro Gly 
            20                  25                  30          


Ser Gly Trp Ala Ala Lys Gly Thr Val Arg Gly Trp Asn Arg Arg Ala 
        35                  40                  45              


Arg Glu Ser Pro Gly His Val Ser Glu Pro Asp Arg Thr Gln Leu Ser 
    50                  55                  60                  


Gln Asp Leu Gly Gly Gly Thr Leu Ala Met Asp Thr Leu Pro Asp Asn 
65                  70                  75                  80  


Arg Thr Arg Val Val Glu Asp Asn His Ser Tyr Tyr Val Ser Arg Leu 
                85                  90                  95      


Tyr Gly Pro Ser Glu Pro His Ser Arg Glu Leu Trp Val Asp Val Ala 
            100                 105                 110         


Glu Ala Asn Arg Ser Gln Val Lys Ile His Thr Ile Leu Ser Asn Thr 
        115                 120                 125             


His Arg Gln Ala Ser Arg Val Val Leu Ser Phe Asp Phe Pro Phe Tyr 
    130                 135                 140                 


Gly His Pro Leu Arg Gln Ile Thr Ile Ala Thr Gly Gly Phe Ile Phe 
145                 150                 155                 160 


Met Gly Asp Val Ile His Arg Met Leu Thr Ala Thr Gln Tyr Val Ala 
                165                 170                 175     


Pro Leu Met Ala Asn Phe Asn Pro Gly Tyr Ser Asp Asn Ser Thr Val 
            180                 185                 190         


Val Tyr Phe Asp Asn Gly Thr Val Phe Val Val Gln Trp Asp His Val 
        195                 200                 205             


Tyr Leu Gln Gly Trp Glu Asp Lys Gly Ser Phe Thr Phe Gln Ala Ala 
    210                 215                 220                 


Leu His His Asp Gly Arg Ile Val Phe Ala Tyr Lys Glu Ile Pro Met 
225                 230                 235                 240 


Ser Val Pro Glu Ile Ser Ser Ser Gln His Pro Val Lys Thr Gly Leu 
                245                 250                 255     


Ser Asp Ala Phe Met Ile Leu Asn Pro Ser Pro Asp Val Pro Glu Ser 
            260                 265                 270         


Arg Arg Arg Ser Ile Phe Glu Tyr His Arg Ile Glu Leu Asp Pro Ser 
        275                 280                 285             


Lys Val Thr Ser Met Ser Ala Val Glu Phe Thr Pro Leu Pro Thr Cys 
    290                 295                 300                 


Leu Gln His Arg Ser Cys Asp Ala Cys Met Ser Ser Asp Leu Thr Phe 
305                 310                 315                 320 


Asn Cys Ser Trp Cys His Val Leu Gln Arg Cys Ser Ser Gly Phe Asp 
                325                 330                 335     


Arg Tyr Arg Gln Glu Trp Met Asp Tyr Gly Cys Ala Gln Glu Ala Glu 
            340                 345                 350         


Gly Arg Met Cys Glu Asp Phe Gln Asp Glu Asp His Asp Ser Ala Ser 
        355                 360                 365             


Pro Asp Thr Ser Phe Ser Pro Tyr Asp Gly Asp Leu Thr Thr Thr Ser 
    370                 375                 380                 


Ser Ser Leu Phe Ile Asp Ser Leu Thr Thr Glu Asp Asp Thr Lys Leu 
385                 390                 395                 400 


Asn Pro Tyr Ala Gly Gly Asp Gly Leu Gln Asn Asn Leu Ser Pro Lys 
                405                 410                 415     


Thr Lys Gly Thr Pro Val His Leu Gly Thr Ile Val Gly Ile Val Leu 
            420                 425                 430         


Ala Val Leu Leu Val Ala Ala Ile Ile Leu Ala Gly Ile Tyr Ile Asn 
        435                 440                 445             


Gly His Pro Thr Ser Asn Ala Ala Leu Phe Phe Ile Glu Arg Arg Pro 
    450                 455                 460                 


His His Trp Pro Ala Met Lys Phe Arg Ser His Pro Asp His Ser Thr 
465                 470                 475                 480 


Tyr Ala Glu Val Glu Pro Ser Gly His Glu Lys Glu Gly Phe Met Glu 
                485                 490                 495     


Ala Glu Gln Cys 
            500 


<210>  4651
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  4651

Met Ala Gly Ser Pro Ser Arg Ala Ala Gly Arg Arg Leu Gln Leu Pro 
1               5                   10                  15      


Leu Leu Cys Leu Phe Leu Gln Gly Ala Thr Ala Val Leu Phe Ala Val 
            20                  25                  30          


Phe Val Arg Tyr Asn His Lys Thr Asp Ala Ala Leu Trp His Arg Ser 
        35                  40                  45              


Asn His Ser Asn Ala Asp Asn Glu Phe Tyr Phe Arg Tyr Pro Ser Phe 
    50                  55                  60                  


Gln Asp Val His Ala Met Val Phe Val Gly Phe Gly Phe Leu Met Val 
65                  70                  75                  80  


Phe Leu Gln Arg Tyr Gly Phe Ser Ser Val Gly Phe Thr Phe Leu Leu 
                85                  90                  95      


Ala Ala Phe Ala Leu Gln Trp Ser Thr Leu Val Gln Gly Phe Leu His 
            100                 105                 110         


Ser Phe His Gly Gly His Ile His Val Gly Val Glu Ser Met Ile Asn 
        115                 120                 125             


Ala Asp Phe Cys Ala Gly Ala Val Leu Ile Ser Phe Gly Ala Val Leu 
    130                 135                 140                 


Gly Lys Thr Gly Pro Thr Gln Leu Leu Leu Met Ala Leu Leu Glu Val 
145                 150                 155                 160 


Val Leu Phe Gly Ile Asn Glu Phe Val Leu Leu His Leu Leu Gly Val 
                165                 170                 175     


Arg Asp Ala Gly Gly Ser Met Thr Ile His Thr Phe Gly Ala Tyr Phe 
            180                 185                 190         


Gly Leu Val Leu Ser Arg Val Leu Tyr Arg Pro Gln Leu Glu Lys Ser 
        195                 200                 205             


Lys His Arg Gln Gly Ser Val Tyr His Ser Asp Leu Phe Ala Met Ile 
    210                 215                 220                 


Gly Thr Ile Phe Leu Trp Ile Phe Trp Pro Ser Phe Asn Ala Ala Leu 
225                 230                 235                 240 


Thr Ala Leu Gly Ala Gly Gln His Arg Thr Ala Leu Asn Thr Tyr Tyr 
                245                 250                 255     


Ser Leu Ala Ala Ser Thr Leu Gly Thr Phe Ala Leu Ser Ala Leu Val 
            260                 265                 270         


Gly Glu Asp Gly Arg Leu Asp Met Val His Ile Gln Asn Ala Ala Leu 
        275                 280                 285             


Ala Gly Gly Val Val Val Gly Thr Ser Ser Glu Met Met Leu Thr Pro 
    290                 295                 300                 


Phe Gly Ala Leu Ala Ala Gly Phe Leu Ala Gly Thr Val Ser Thr Leu 
305                 310                 315                 320 


Gly Tyr Lys Phe Phe Thr Pro Ile Leu Glu Ser Lys Phe Lys Val Gln 
                325                 330                 335     


Asp Thr Cys Gly Val His Asn Leu His Gly Met Pro Gly Val Leu Gly 
            340                 345                 350         


Ala Leu Leu Gly Val Leu Val Ala Gly Leu Ala Thr His Glu Ala Tyr 
        355                 360                 365             


Gly Asp Gly Leu Glu Ser Val Phe Pro Leu Ile Ala Glu Gly Gln Arg 
    370                 375                 380                 


Ser Ala Thr Ser Gln Ala Met His Gln Leu Phe Gly Leu Phe Val Thr 
385                 390                 395                 400 


Leu Met Phe Ala Ser Val Gly Gly Gly Leu Gly Gly Leu Leu Leu Lys 
                405                 410                 415     


Leu Pro Phe Leu Asp Ser Pro Pro Asp Ser Gln His Tyr Glu Asp Gln 
            420                 425                 430         


Val His Trp Gln Val Pro Gly Glu His Glu Asp Lys Ala Gln Arg Pro 
        435                 440                 445             


Leu Arg Val Glu Glu Ala Asp Thr Gln Ala 
    450                 455             


<210>  4652
<211>  1204
<212>  PRT
<213>  Homo sapiens

<400>  4652

Met Ala Ala Ala Ala Ala Val Gly Asn Ala Val Pro Cys Gly Ala Arg 
1               5                   10                  15      


Pro Cys Gly Val Arg Pro Asp Gly Gln Pro Lys Pro Gly Pro Gln Pro 
            20                  25                  30          


Arg Ala Leu Leu Ala Ala Gly Pro Ala Leu Ile Ala Asn Gly Asp Glu 
        35                  40                  45              


Leu Val Ala Ala Val Trp Pro Tyr Arg Arg Leu Ala Leu Leu Arg Arg 
    50                  55                  60                  


Leu Thr Val Leu Pro Phe Ala Gly Leu Leu Tyr Pro Ala Trp Leu Gly 
65                  70                  75                  80  


Ala Ala Ala Ala Gly Cys Trp Gly Trp Gly Ser Ser Trp Val Gln Ile 
                85                  90                  95      


Pro Glu Ala Ala Leu Leu Val Leu Ala Thr Ile Cys Leu Ala His Ala 
            100                 105                 110         


Leu Thr Val Leu Ser Gly His Trp Ser Val His Ala His Cys Ala Leu 
        115                 120                 125             


Thr Cys Thr Pro Glu Tyr Asp Pro Ser Lys Ala Thr Phe Val Lys Val 
    130                 135                 140                 


Val Pro Thr Pro Asn Asn Gly Ser Thr Glu Leu Val Ala Leu His Arg 
145                 150                 155                 160 


Asn Glu Gly Glu Asp Gly Leu Glu Val Leu Ser Phe Glu Phe Gln Lys 
                165                 170                 175     


Ile Lys Tyr Ser Tyr Asp Ala Leu Glu Lys Lys Gln Phe Leu Pro Val 
            180                 185                 190         


Ala Phe Pro Val Gly Asn Ala Phe Ser Tyr Tyr Gln Ser Asn Arg Gly 
        195                 200                 205             


Phe Gln Glu Asp Ser Glu Ile Arg Ala Ala Glu Lys Lys Phe Gly Ser 
    210                 215                 220                 


Asn Lys Ala Glu Met Val Val Pro Asp Phe Ser Glu Leu Phe Lys Glu 
225                 230                 235                 240 


Arg Ala Thr Ala Pro Phe Phe Val Phe Gln Val Phe Cys Val Gly Leu 
                245                 250                 255     


Trp Cys Leu Asp Glu Tyr Trp Tyr Tyr Ser Val Phe Thr Leu Ser Met 
            260                 265                 270         


Leu Val Ala Phe Glu Ala Ser Leu Val Gln Gln Gln Met Arg Asn Met 
        275                 280                 285             


Ser Glu Ile Arg Lys Met Gly Asn Lys Pro His Met Ile Gln Val Tyr 
    290                 295                 300                 


Arg Ser Arg Lys Trp Arg Pro Ile Ala Ser Asp Glu Ile Val Pro Gly 
305                 310                 315                 320 


Asp Ile Val Ser Ile Gly Arg Ser Pro Gln Glu Asn Leu Val Pro Cys 
                325                 330                 335     


Asp Val Leu Leu Leu Arg Gly Arg Cys Ile Val Asp Glu Ala Met Leu 
            340                 345                 350         


Thr Gly Glu Ser Val Pro Gln Met Lys Glu Pro Ile Glu Asp Leu Ser 
        355                 360                 365             


Pro Asp Arg Val Leu Asp Leu Gln Ala Asp Ser Arg Leu His Val Ile 
    370                 375                 380                 


Phe Gly Gly Thr Lys Val Val Gln His Ile Pro Pro Gln Lys Ala Thr 
385                 390                 395                 400 


Thr Gly Leu Lys Pro Val Asp Ser Gly Cys Val Ala Tyr Val Leu Arg 
                405                 410                 415     


Thr Gly Phe Asn Thr Ser Gln Gly Lys Leu Leu Arg Thr Ile Leu Phe 
            420                 425                 430         


Gly Val Lys Arg Val Thr Ala Asn Asn Leu Glu Thr Phe Ile Phe Ile 
        435                 440                 445             


Leu Phe Leu Leu Val Phe Ala Ile Ala Ala Ala Ala Tyr Val Trp Ile 
    450                 455                 460                 


Glu Gly Thr Lys Asp Pro Ser Arg Asn Arg Tyr Lys Leu Phe Leu Glu 
465                 470                 475                 480 


Cys Thr Leu Ile Leu Thr Ser Val Val Pro Pro Glu Leu Pro Ile Glu 
                485                 490                 495     


Leu Ser Leu Ala Val Asn Thr Ser Leu Ile Ala Leu Ala Lys Leu Tyr 
            500                 505                 510         


Met Tyr Cys Thr Glu Pro Phe Arg Ile Pro Phe Ala Gly Lys Val Glu 
        515                 520                 525             


Val Cys Cys Phe Asp Lys Thr Gly Thr Leu Thr Ser Asp Ser Leu Val 
    530                 535                 540                 


Val Arg Gly Val Ala Gly Leu Arg Asp Gly Lys Glu Val Thr Pro Val 
545                 550                 555                 560 


Ser Ser Ile Pro Val Glu Thr His Arg Ala Leu Ala Ser Cys His Ser 
                565                 570                 575     


Leu Met Gln Leu Asp Asp Gly Thr Leu Val Gly Asp Pro Leu Glu Lys 
            580                 585                 590         


Ala Met Leu Thr Ala Val Asp Trp Thr Leu Thr Lys Asp Glu Lys Val 
        595                 600                 605             


Phe Pro Arg Ser Ile Lys Thr Gln Gly Leu Lys Ile His Gln Arg Phe 
    610                 615                 620                 


His Phe Ala Ser Ala Leu Lys Arg Met Ser Val Leu Ala Ser Tyr Glu 
625                 630                 635                 640 


Lys Leu Gly Ser Thr Asp Leu Cys Tyr Ile Ala Ala Val Lys Gly Ala 
                645                 650                 655     


Pro Glu Thr Leu His Ser Met Phe Ser Gln Cys Pro Pro Asp Tyr His 
            660                 665                 670         


His Ile His Thr Glu Ile Ser Arg Glu Gly Ala Arg Val Leu Ala Leu 
        675                 680                 685             


Gly Tyr Lys Glu Leu Gly His Leu Thr His Gln Gln Ala Arg Glu Val 
    690                 695                 700                 


Lys Arg Glu Ala Leu Glu Cys Ser Leu Lys Phe Val Gly Phe Ile Val 
705                 710                 715                 720 


Val Ser Cys Pro Leu Lys Ala Asp Ser Lys Ala Val Ile Arg Glu Ile 
                725                 730                 735     


Gln Asn Ala Ser His Arg Val Val Met Ile Thr Gly Asp Asn Pro Leu 
            740                 745                 750         


Thr Ala Cys His Val Ala Gln Glu Leu His Phe Ile Glu Lys Ala His 
        755                 760                 765             


Thr Leu Ile Leu Gln Pro Pro Ser Glu Lys Gly Arg Gln Cys Glu Trp 
    770                 775                 780                 


Arg Ser Ile Asp Gly Ser Ile Val Leu Pro Leu Ala Arg Gly Ser Pro 
785                 790                 795                 800 


Lys Ala Leu Ala Leu Glu Tyr Ala Leu Cys Leu Thr Gly Asp Gly Leu 
                805                 810                 815     


Ala His Leu Gln Ala Thr Asp Pro Gln Gln Leu Leu Arg Leu Ile Pro 
            820                 825                 830         


His Val Gln Val Phe Ala Arg Val Ala Pro Lys Gln Lys Glu Phe Val 
        835                 840                 845             


Ile Thr Ser Leu Lys Glu Leu Gly Tyr Val Thr Leu Met Cys Gly Asp 
    850                 855                 860                 


Gly Thr Asn Asp Val Gly Ala Leu Lys His Ala Asp Val Gly Val Ala 
865                 870                 875                 880 


Leu Leu Ala Asn Ala Pro Glu Arg Val Val Glu Arg Arg Arg Arg Pro 
                885                 890                 895     


Arg Asp Ser Pro Thr Leu Ser Asn Ser Gly Ile Arg Ala Thr Ser Arg 
            900                 905                 910         


Thr Ala Lys Gln Arg Ser Gly Leu Pro Pro Ser Glu Glu Gln Pro Thr 
        915                 920                 925             


Ser Gln Arg Asp Arg Leu Ser Gln Val Leu Arg Asp Leu Glu Asp Glu 
    930                 935                 940                 


Ser Thr Pro Ile Val Lys Leu Gly Asp Ala Ser Ile Ala Ala Pro Phe 
945                 950                 955                 960 


Thr Ser Lys Leu Ser Ser Ile Gln Cys Ile Cys His Val Ile Lys Gln 
                965                 970                 975     


Gly Arg Cys Thr Leu Val Thr Thr Leu Gln Met Phe Lys Ile Leu Ala 
            980                 985                 990         


Leu Asn Ala Leu Ile Leu Ala Tyr  Ser Gln Ser Val Leu  Tyr Leu Glu 
        995                 1000                 1005             


Gly Val  Lys Phe Ser Asp Phe  Gln Ala Thr Leu Gln  Gly Leu Leu 
    1010                 1015                 1020             


Leu Ala  Gly Cys Phe Leu Phe  Ile Ser Arg Ser Lys  Pro Leu Lys 
    1025                 1030                 1035             


Thr Leu  Ser Arg Glu Arg Pro  Leu Pro Asn Ile Phe  Asn Leu Tyr 
    1040                 1045                 1050             


Thr Ile  Leu Thr Val Met Leu  Gln Phe Phe Val His  Phe Leu Ser 
    1055                 1060                 1065             


Leu Val  Tyr Leu Tyr Arg Glu  Ala Gln Ala Arg Ser  Pro Glu Lys 
    1070                 1075                 1080             


Gln Glu  Gln Phe Val Asp Leu  Tyr Lys Glu Phe Glu  Pro Ser Leu 
    1085                 1090                 1095             


Val Asn  Ser Thr Val Tyr Ile  Met Ala Met Ala Met  Gln Met Ala 
    1100                 1105                 1110             


Thr Phe  Ala Ile Asn Tyr Lys  Gly Pro Pro Phe Met  Glu Ser Leu 
    1115                 1120                 1125             


Pro Glu  Asn Lys Pro Leu Val  Trp Ser Leu Ala Val  Ser Leu Leu 
    1130                 1135                 1140             


Ala Ile  Ile Gly Leu Leu Leu  Gly Ser Ser Pro Asp  Phe Asn Ser 
    1145                 1150                 1155             


Gln Phe  Gly Leu Val Asp Ile  Pro Val Glu Phe Lys  Leu Val Ile 
    1160                 1165                 1170             


Ala Gln  Val Leu Leu Leu Asp  Phe Cys Leu Ala Leu  Leu Ala Asp 
    1175                 1180                 1185             


Arg Val  Leu Gln Phe Phe Leu  Gly Thr Pro Lys Leu  Lys Val Pro 
    1190                 1195                 1200             


Ser 
    


<210>  4653
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  4653

Met Ala Lys Glu Glu Pro Gln Ser Ile Ser Arg Asp Leu Gln Glu Leu 
1               5                   10                  15      


Gln Lys Lys Leu Ser Leu Leu Ile Asp Ser Phe Gln Asn Asn Ser Lys 
            20                  25                  30          


Val Val Ala Phe Met Lys Ser Pro Val Gly Gln Tyr Leu Asp Ser His 
        35                  40                  45              


Pro Phe Leu Ala Phe Thr Leu Leu Val Phe Ile Val Met Ser Ala Val 
    50                  55                  60                  


Pro Val Gly Phe Phe Leu Leu Ile Val Val Leu Thr Thr Leu Ala Ala 
65                  70                  75                  80  


Leu Leu Gly Val Ile Ile Leu Glu Gly Leu Val Ile Ser Val Gly Gly 
                85                  90                  95      


Phe Ser Leu Leu Cys Ile Leu Cys Gly Leu Gly Phe Val Ser Leu Ala 
            100                 105                 110         


Met Ser Gly Met Met Ile Ala Ser Tyr Val Val Val Ser Ser Leu Ile 
        115                 120                 125             


Ser Cys Trp Phe Ser Pro Arg Pro Leu Thr Gln Gln Asn Thr Ser Cys 
    130                 135                 140                 


Asp Phe Leu Pro Ala Met Lys Ser Ala Glu Phe Glu Gly Leu Tyr Gln 
145                 150                 155                 160 


Glu 
    


<210>  4654
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  4654

Met Ser Ser Ala Pro Glu Pro Pro Thr Phe Lys Lys Glu Pro Pro Lys 
1               5                   10                  15      


Glu Lys Glu Phe Gln Ser Pro Gly Leu Arg Gly Val Arg Thr Thr Thr 
            20                  25                  30          


Leu Phe Arg Ala Val Asn Pro Glu Leu Phe Ile Lys Pro Asn Lys Pro 
        35                  40                  45              


Val Met Ala Phe Gly Leu Val Thr Leu Ser Leu Cys Val Ala Tyr Ile 
    50                  55                  60                  


Gly Tyr Leu His Ala Ile Gln Glu Asn Lys Lys Asp Leu Tyr Glu Ala 
65                  70                  75                  80  


Ile Asp Ser Glu Gly His Ser Tyr Met Arg Arg Lys Thr Ser Lys Trp 
                85                  90                  95      


Asp 
    


<210>  4655
<211>  706
<212>  PRT
<213>  Homo sapiens

<400>  4655

Met Gly Asp Glu Arg Pro His Tyr Tyr Gly Lys His Gly Thr Pro Gln 
1               5                   10                  15      


Lys Tyr Asp Pro Thr Phe Lys Gly Pro Ile Tyr Asn Arg Gly Cys Thr 
            20                  25                  30          


Asp Ile Ile Cys Cys Val Phe Leu Leu Leu Ala Ile Val Gly Tyr Val 
        35                  40                  45              


Ala Val Gly Ile Ile Ala Trp Thr His Gly Asp Pro Arg Lys Val Ile 
    50                  55                  60                  


Tyr Pro Thr Asp Ser Arg Gly Glu Phe Cys Gly Gln Lys Gly Thr Lys 
65                  70                  75                  80  


Asn Glu Asn Lys Pro Tyr Leu Phe Tyr Phe Asn Ile Val Lys Cys Ala 
                85                  90                  95      


Ser Pro Leu Val Leu Leu Glu Phe Gln Cys Pro Thr Pro Gln Ile Cys 
            100                 105                 110         


Val Glu Lys Cys Pro Asp Arg Tyr Leu Thr Tyr Leu Asn Ala Arg Ser 
        115                 120                 125             


Ser Arg Asp Phe Glu Tyr Tyr Lys Gln Phe Cys Val Pro Gly Phe Lys 
    130                 135                 140                 


Asn Asn Lys Gly Val Ala Glu Val Leu Gln Asp Gly Asp Cys Pro Ala 
145                 150                 155                 160 


Val Leu Ile Pro Ser Lys Pro Leu Ala Arg Arg Cys Phe Pro Ala Ile 
                165                 170                 175     


His Ala Tyr Lys Gly Val Leu Met Val Gly Asn Glu Thr Thr Tyr Glu 
            180                 185                 190         


Asp Gly His Gly Ser Arg Lys Asn Ile Thr Asp Leu Val Glu Gly Ala 
        195                 200                 205             


Lys Lys Ala Asn Gly Val Leu Glu Ala Arg Gln Leu Ala Met Arg Ile 
    210                 215                 220                 


Phe Glu Asp Tyr Thr Val Ser Trp Tyr Trp Ile Ile Ile Gly Leu Val 
225                 230                 235                 240 


Ile Ala Met Ala Met Ser Leu Leu Phe Ile Ile Leu Leu Arg Phe Leu 
                245                 250                 255     


Ala Gly Ile Met Val Trp Val Met Ile Ile Met Val Ile Leu Val Leu 
            260                 265                 270         


Gly Tyr Gly Ile Phe His Cys Tyr Met Glu Tyr Ser Arg Leu Arg Gly 
        275                 280                 285             


Glu Ala Gly Ser Asp Val Ser Leu Val Asp Leu Gly Phe Gln Thr Asp 
    290                 295                 300                 


Phe Arg Val Tyr Leu His Leu Arg Gln Thr Trp Leu Ala Phe Met Ile 
305                 310                 315                 320 


Ile Leu Ser Ile Leu Glu Val Ile Ile Ile Leu Leu Leu Ile Phe Leu 
                325                 330                 335     


Arg Lys Arg Ile Leu Ile Ala Ile Ala Leu Ile Lys Glu Ala Ser Arg 
            340                 345                 350         


Ala Val Gly Tyr Val Met Cys Ser Leu Leu Tyr Pro Leu Val Thr Phe 
        355                 360                 365             


Phe Leu Leu Cys Leu Cys Ile Ala Tyr Trp Ala Ser Thr Ala Val Phe 
    370                 375                 380                 


Leu Ser Thr Ser Asn Glu Ala Val Tyr Lys Ile Phe Asp Asp Ser Pro 
385                 390                 395                 400 


Cys Pro Phe Thr Ala Lys Thr Cys Asn Pro Glu Thr Phe Pro Ser Ser 
                405                 410                 415     


Asn Glu Ser Arg Gln Cys Pro Asn Ala Arg Cys Gln Phe Ala Phe Tyr 
            420                 425                 430         


Gly Gly Glu Ser Gly Tyr His Arg Ala Leu Leu Gly Leu Gln Ile Phe 
        435                 440                 445             


Asn Ala Phe Met Phe Phe Trp Leu Ala Asn Phe Val Leu Ala Leu Gly 
    450                 455                 460                 


Gln Val Thr Leu Ala Gly Ala Phe Ala Ser Tyr Tyr Trp Ala Leu Arg 
465                 470                 475                 480 


Lys Pro Asp Asp Leu Pro Ala Phe Pro Leu Phe Ser Ala Phe Gly Arg 
                485                 490                 495     


Ala Leu Arg Tyr His Thr Gly Ser Leu Ala Phe Gly Ala Leu Ile Leu 
            500                 505                 510         


Ala Ile Val Gln Ile Ile Arg Val Ile Leu Glu Tyr Leu Asp Gln Arg 
        515                 520                 525             


Leu Lys Ala Ala Glu Asn Lys Phe Ala Lys Cys Leu Met Thr Cys Leu 
    530                 535                 540                 


Lys Cys Cys Phe Trp Cys Leu Glu Lys Phe Ile Lys Phe Leu Asn Arg 
545                 550                 555                 560 


Asn Ala Tyr Ile Met Ile Ala Ile Tyr Gly Thr Asn Phe Cys Thr Ser 
                565                 570                 575     


Ala Arg Asn Ala Phe Phe Leu Leu Met Arg Asn Ile Ile Arg Val Ala 
            580                 585                 590         


Val Leu Asp Lys Val Thr Asp Phe Leu Phe Leu Leu Gly Lys Leu Leu 
        595                 600                 605             


Ile Val Gly Ser Val Gly Ile Leu Ala Phe Phe Phe Phe Thr His Arg 
    610                 615                 620                 


Ile Arg Ile Val Gln Asp Thr Ala Pro Pro Leu Asn Tyr Tyr Trp Val 
625                 630                 635                 640 


Pro Ile Leu Thr Val Ile Val Gly Ser Tyr Leu Ile Ala His Gly Phe 
                645                 650                 655     


Phe Ser Val Tyr Gly Met Cys Val Asp Thr Leu Phe Leu Cys Phe Leu 
            660                 665                 670         


Glu Asp Leu Glu Arg Asn Asp Gly Ser Ala Glu Arg Pro Tyr Phe Met 
        675                 680                 685             


Ser Ser Thr Leu Lys Lys Leu Leu Asn Lys Thr Asn Lys Lys Ala Ala 
    690                 695                 700                 


Glu Ser 
705     


<210>  4656
<211>  806
<212>  PRT
<213>  Homo sapiens

<400>  4656

Met Ser Ala Ser Pro Asp Asp Leu Ser Thr Gly Gly Arg Leu Gln Asn 
1               5                   10                  15      


Met Thr Val Asp Glu Cys Phe Gln Ser Arg Asn Thr Val Leu Gln Gly 
            20                  25                  30          


Gln Pro Phe Gly Gly Val Pro Thr Val Leu Cys Leu Asn Ile Ala Leu 
        35                  40                  45              


Trp Val Leu Val Leu Val Val Tyr Ser Phe Leu Arg Lys Ala Ala Trp 
    50                  55                  60                  


Asp Tyr Gly Arg Leu Ala Leu Leu Ile His Asn Asp Ser Leu Thr Ser 
65                  70                  75                  80  


Leu Ile Tyr Gly Glu Gln Ser Glu Lys Thr Ser Pro Ser Glu Thr Ser 
                85                  90                  95      


Leu Glu Met Glu Arg Arg Asp Lys Gly Phe Cys Ser Trp Phe Phe Asn 
            100                 105                 110         


Ser Ile Thr Met Lys Asp Glu Asp Leu Ile Asn Lys Cys Gly Asp Asp 
        115                 120                 125             


Ala Arg Ile Tyr Ile Val Phe Gln Tyr His Leu Ile Ile Phe Val Leu 
    130                 135                 140                 


Ile Ile Cys Ile Pro Ser Leu Gly Ile Ile Leu Pro Ile Asn Tyr Thr 
145                 150                 155                 160 


Gly Ser Val Leu Asp Trp Ser Ser His Phe Ala Arg Thr Thr Ile Val 
                165                 170                 175     


Asn Val Ser Thr Glu Ser Lys Leu Leu Trp Leu His Ser Leu Leu Ser 
            180                 185                 190         


Phe Phe Tyr Phe Ile Thr Asn Phe Met Phe Met Ala His His Cys Leu 
        195                 200                 205             


Gly Phe Ala Pro Arg Asn Ser Gln Lys Val Thr Arg Thr Leu Met Ile 
    210                 215                 220                 


Thr Tyr Val Pro Lys Asp Ile Glu Asp Pro Glu Leu Ile Ile Lys His 
225                 230                 235                 240 


Phe His Glu Ala Tyr Pro Gly Ser Val Val Thr Arg Val His Phe Cys 
                245                 250                 255     


Tyr Asp Val Arg Asn Leu Ile Asp Leu Asp Asp Gln Arg Arg His Ala 
            260                 265                 270         


Met Arg Gly Arg Leu Phe Tyr Thr Ala Lys Ala Lys Lys Thr Gly Lys 
        275                 280                 285             


Val Met Ile Arg Ile His Pro Cys Ala Arg Leu Cys Phe Cys Lys Cys 
    290                 295                 300                 


Trp Thr Cys Phe Lys Glu Val Asp Ala Glu Gln Tyr Tyr Ser Glu Leu 
305                 310                 315                 320 


Glu Glu Gln Leu Thr Asp Glu Phe Asn Ala Glu Leu Asn Arg Val Pro 
                325                 330                 335     


Leu Lys Arg Leu Asp Leu Ile Phe Val Thr Phe Gln Asp Ser Arg Met 
            340                 345                 350         


Ala Lys Arg Val Arg Lys Asp Tyr Lys Tyr Val Gln Cys Gly Val Gln 
        355                 360                 365             


Pro Gln Gln Ser Ser Val Thr Thr Ile Val Lys Ser Tyr Tyr Trp Arg 
    370                 375                 380                 


Val Thr Met Ala Pro His Pro Lys Asp Ile Ile Trp Lys His Leu Ser 
385                 390                 395                 400 


Val Arg Arg Phe Phe Trp Trp Ala Arg Phe Ile Ala Ile Asn Thr Phe 
                405                 410                 415     


Leu Phe Phe Leu Phe Phe Phe Leu Thr Thr Pro Ala Ile Ile Met Asn 
            420                 425                 430         


Thr Ile Asp Met Tyr Asn Val Thr Arg Pro Ile Glu Lys Leu Gln Asn 
        435                 440                 445             


Pro Ile Val Thr Gln Phe Phe Pro Ser Val Met Leu Trp Gly Phe Thr 
    450                 455                 460                 


Val Ile Leu Pro Leu Ile Val Tyr Phe Ser Ala Phe Leu Glu Ala His 
465                 470                 475                 480 


Trp Thr Arg Ser Ser Gln Asn Leu Val Met Val His Lys Cys Tyr Ile 
                485                 490                 495     


Phe Leu Val Phe Met Val Val Ile Leu Pro Ser Met Gly Leu Thr Ser 
            500                 505                 510         


Leu Asp Val Phe Leu Arg Trp Leu Phe Asp Ile Tyr Tyr Leu Glu Gln 
        515                 520                 525             


Ala Ser Ile Arg Phe Gln Cys Val Phe Leu Pro Asp Asn Gly Ala Phe 
    530                 535                 540                 


Phe Val Asn Tyr Val Ile Thr Ala Ala Leu Leu Gly Thr Gly Met Glu 
545                 550                 555                 560 


Leu Leu Arg Leu Gly Ser Leu Phe Cys Tyr Ser Thr Arg Leu Phe Phe 
                565                 570                 575     


Ser Arg Ser Glu Pro Glu Arg Val Asn Ile Arg Lys Asn Gln Ala Ile 
            580                 585                 590         


Asp Phe Gln Phe Gly Arg Glu Tyr Ala Trp Met Met Asn Val Phe Ser 
        595                 600                 605             


Val Val Met Ala Tyr Ser Ile Thr Cys Pro Ile Ile Val Pro Phe Gly 
    610                 615                 620                 


Leu Leu Tyr Leu Cys Met Lys His Leu Thr Asp Arg Tyr Asn Met Tyr 
625                 630                 635                 640 


Tyr Ser Phe Ala Pro Thr Lys Leu Asn Glu Gln Ile His Met Ala Ala 
                645                 650                 655     


Val Ser Gln Ala Ile Phe Ala Pro Leu Leu Gly Leu Phe Trp Met Leu 
            660                 665                 670         


Phe Phe Ser Ile Leu Arg Leu Gly Ser Leu His Ala Ile Thr Ile Phe 
        675                 680                 685             


Ser Leu Ser Thr Leu Leu Ile Ala Met Val Ile Ala Phe Val Gly Ile 
    690                 695                 700                 


Phe Leu Gly Lys Leu Arg Met Val Ala Asp Tyr Glu Pro Glu Glu Glu 
705                 710                 715                 720 


Glu Ile Gln Thr Val Phe Asp Met Glu Pro Ser Ser Thr Ser Ser Thr 
                725                 730                 735     


Pro Thr Ser Leu Leu Tyr Val Ala Thr Val Leu Gln Glu Pro Glu Leu 
            740                 745                 750         


Asn Leu Thr Pro Ala Ser Ser Pro Ala Arg His Thr Tyr Gly Thr Met 
        755                 760                 765             


Asn Asn Gln Pro Glu Glu Gly Glu Glu Glu Ser Gly Leu Arg Gly Phe 
    770                 775                 780                 


Ala Arg Glu Leu Asp Ser Ala Gln Phe Gln Glu Gly Leu Glu Leu Glu 
785                 790                 795                 800 


Gly Gln Asn Gln Tyr His 
                805     


<210>  4657
<211>  696
<212>  PRT
<213>  Homo sapiens

<400>  4657

Met Ser Gly Gly Arg Phe Asp Phe Asp Asp Gly Gly Ala Tyr Cys Gly 
1               5                   10                  15      


Gly Trp Glu Gly Gly Lys Ala His Gly His Gly Leu Cys Thr Gly Pro 
            20                  25                  30          


Lys Gly Gln Gly Glu Tyr Ser Gly Ser Trp Asn Phe Gly Phe Glu Val 
        35                  40                  45              


Ala Gly Val Tyr Thr Trp Pro Ser Gly Asn Thr Phe Glu Gly Tyr Trp 
    50                  55                  60                  


Ser Gln Gly Lys Arg His Gly Leu Gly Ile Glu Thr Lys Gly Arg Trp 
65                  70                  75                  80  


Leu Tyr Lys Gly Glu Trp Thr His Gly Phe Lys Gly Arg Tyr Gly Ile 
                85                  90                  95      


Arg Gln Ser Ser Ser Ser Gly Ala Lys Tyr Glu Gly Thr Trp Asn Asn 
            100                 105                 110         


Gly Leu Gln Asp Gly Tyr Gly Thr Glu Thr Tyr Ala Asp Gly Gly Thr 
        115                 120                 125             


Tyr Gln Gly Gln Phe Thr Asn Gly Met Arg His Gly Tyr Gly Val Arg 
    130                 135                 140                 


Gln Ser Val Pro Tyr Gly Met Ala Val Val Val Arg Ser Pro Leu Arg 
145                 150                 155                 160 


Thr Ser Leu Ser Ser Leu Arg Ser Glu His Ser Asn Gly Thr Val Ala 
                165                 170                 175     


Pro Asp Ser Pro Ala Ser Pro Ala Ser Asp Gly Pro Ala Leu Pro Ser 
            180                 185                 190         


Pro Ala Ile Pro Arg Gly Gly Phe Ala Leu Ser Leu Leu Ala Asn Ala 
        195                 200                 205             


Glu Ala Ala Ala Arg Ala Pro Lys Gly Gly Gly Leu Phe Gln Arg Gly 
    210                 215                 220                 


Ala Leu Leu Gly Lys Leu Arg Arg Ala Glu Ser Arg Thr Ser Val Gly 
225                 230                 235                 240 


Ser Gln Arg Ser Arg Val Ser Phe Leu Lys Ser Asp Leu Ser Ser Gly 
                245                 250                 255     


Ala Ser Asp Ala Ala Ser Thr Ala Ser Leu Gly Glu Ala Ala Glu Gly 
            260                 265                 270         


Ala Asp Glu Ala Ala Pro Phe Glu Ala Asp Ile Asp Ala Thr Thr Thr 
        275                 280                 285             


Glu Thr Tyr Met Gly Glu Trp Lys Asn Asp Lys Arg Ser Gly Phe Gly 
    290                 295                 300                 


Val Ser Glu Arg Ser Ser Gly Leu Arg Tyr Glu Gly Glu Trp Leu Asp 
305                 310                 315                 320 


Asn Leu Arg His Gly Tyr Gly Cys Thr Thr Leu Pro Asp Gly His Arg 
                325                 330                 335     


Glu Glu Gly Lys Tyr Arg His Asn Val Leu Val Lys Asp Thr Lys Arg 
            340                 345                 350         


Arg Met Leu Gln Leu Lys Ser Asn Lys Val Arg Gln Lys Val Glu His 
        355                 360                 365             


Ser Val Glu Gly Ala Gln Arg Ala Ala Ala Ile Ala Arg Gln Lys Ala 
    370                 375                 380                 


Glu Ile Ala Ala Ser Arg Thr Ser His Ala Lys Ala Lys Ala Glu Ala 
385                 390                 395                 400 


Ala Glu Gln Ala Ala Leu Ala Ala Asn Gln Glu Ser Asn Ile Ala Arg 
                405                 410                 415     


Thr Leu Ala Arg Glu Leu Ala Pro Asp Phe Tyr Gln Pro Gly Pro Glu 
            420                 425                 430         


Tyr Gln Lys Arg Arg Leu Leu Gln Glu Ile Leu Glu Asn Ser Glu Ser 
        435                 440                 445             


Leu Leu Glu Pro Pro Asp Arg Gly Ala Gly Ala Ala Gly Leu Pro Gln 
    450                 455                 460                 


Pro Pro Arg Glu Ser Pro Gln Leu His Glu Arg Glu Thr Pro Arg Pro 
465                 470                 475                 480 


Glu Gly Gly Ser Pro Ser Pro Ala Gly Thr Pro Pro Gln Pro Lys Arg 
                485                 490                 495     


Pro Arg Pro Gly Val Ser Lys Asp Gly Leu Leu Ser Pro Gly Ala Trp 
            500                 505                 510         


Asn Gly Glu Pro Ser Gly Glu Gly Ser Arg Ser Val Thr Pro Ser Glu 
        515                 520                 525             


Gly Ala Gly Arg Arg Ser Pro Ala Arg Pro Ala Thr Glu Arg Met Ala 
    530                 535                 540                 


Ile Glu Ala Leu Gln Ala Pro Pro Ala Pro Ser Arg Glu Pro Glu Val 
545                 550                 555                 560 


Ala Leu Tyr Gln Gly Tyr His Ser Tyr Ala Val Arg Thr Thr Pro Pro 
                565                 570                 575     


Glu Pro Pro Pro Phe Glu Asp Gln Pro Glu Pro Glu Val Ser Gly Ser 
            580                 585                 590         


Glu Ser Ala Pro Ser Ser Pro Ala Thr Ala Pro Leu Gln Ala Pro Thr 
        595                 600                 605             


Leu Arg Gly Pro Glu Pro Ala Arg Glu Thr Pro Ala Lys Leu Glu Pro 
    610                 615                 620                 


Lys Pro Ile Ile Pro Lys Ala Glu Pro Arg Ala Lys Ala Arg Lys Thr 
625                 630                 635                 640 


Glu Ala Arg Gly Leu Thr Lys Ala Gly Ala Lys Lys Lys Ala Arg Lys 
                645                 650                 655     


Glu Ala Ala Leu Ala Ala Glu Ala Glu Val Glu Val Glu Glu Val Pro 
            660                 665                 670         


Asn Thr Ile Leu Ile Cys Met Val Ile Leu Leu Asn Ile Gly Leu Ala 
        675                 680                 685             


Ile Leu Phe Val His Leu Leu Thr 
    690                 695     


<210>  4658
<211>  439
<212>  PRT
<213>  Homo sapiens

<400>  4658

Met Thr Asn Met Ser Trp Ser Phe Leu Thr Arg Leu Leu Glu Glu Ile 
1               5                   10                  15      


His Asn His Ser Thr Phe Val Gly Lys Val Trp Leu Thr Val Leu Val 
            20                  25                  30          


Val Phe Arg Ile Val Leu Thr Ala Val Gly Gly Glu Ala Ile Tyr Ser 
        35                  40                  45              


Asp Glu Gln Ala Lys Phe Thr Cys Asn Thr Arg Gln Pro Gly Cys Asp 
    50                  55                  60                  


Asn Val Cys Tyr Asp Ala Phe Ala Pro Leu Ser His Val Arg Phe Trp 
65                  70                  75                  80  


Val Phe Gln Ile Val Val Ile Ser Thr Pro Ser Val Met Tyr Leu Gly 
                85                  90                  95      


Tyr Ala Val His Arg Leu Ala Arg Ala Ser Glu Gln Glu Arg Arg Arg 
            100                 105                 110         


Ala Leu Arg Arg Arg Pro Gly Pro Arg Arg Ala Pro Arg Ala His Leu 
        115                 120                 125             


Pro Pro Pro His Ala Gly Trp Pro Glu Pro Ala Asp Leu Gly Glu Glu 
    130                 135                 140                 


Glu Pro Met Leu Gly Leu Gly Glu Glu Glu Glu Glu Glu Glu Thr Gly 
145                 150                 155                 160 


Ala Ala Glu Gly Ala Gly Glu Glu Ala Glu Glu Ala Gly Ala Glu Glu 
                165                 170                 175     


Ala Cys Thr Lys Ala Val Gly Ala Asp Gly Lys Ala Ala Gly Thr Pro 
            180                 185                 190         


Gly Pro Thr Gly Gln His Asp Gly Arg Arg Arg Ile Gln Arg Glu Gly 
        195                 200                 205             


Leu Met Arg Val Tyr Val Ala Gln Leu Val Ala Arg Ala Ala Phe Glu 
    210                 215                 220                 


Val Ala Phe Leu Val Gly Gln Tyr Leu Leu Tyr Gly Phe Glu Val Arg 
225                 230                 235                 240 


Pro Phe Phe Pro Cys Ser Arg Gln Pro Cys Pro His Val Val Asp Cys 
                245                 250                 255     


Phe Val Ser Arg Pro Thr Glu Lys Thr Val Phe Leu Leu Val Met Tyr 
            260                 265                 270         


Val Val Ser Cys Leu Cys Leu Leu Leu Asn Leu Cys Glu Met Ala His 
        275                 280                 285             


Leu Gly Leu Gly Ser Ala Gln Asp Ala Val Arg Gly Arg Arg Gly Pro 
    290                 295                 300                 


Pro Ala Ser Ala Pro Ala Pro Ala Pro Arg Pro Pro Pro Cys Ala Phe 
305                 310                 315                 320 


Pro Ala Ala Ala Ala Gly Leu Ala Cys Pro Pro Asp Tyr Ser Leu Val 
                325                 330                 335     


Val Arg Ala Ala Glu Arg Ala Arg Ala His Asp Gln Asn Leu Ala Asn 
            340                 345                 350         


Leu Ala Leu Gln Ala Leu Arg Asp Gly Ala Ala Ala Gly Asp Arg Asp 
        355                 360                 365             


Arg Asp Ser Ser Pro Cys Val Gly Leu Pro Ala Ala Ser Arg Gly Pro 
    370                 375                 380                 


Pro Arg Ala Gly Ala Pro Ala Ser Arg Thr Gly Ser Ala Thr Ser Ala 
385                 390                 395                 400 


Gly Thr Val Gly Glu Gln Gly Arg Pro Gly Thr His Glu Arg Pro Gly 
                405                 410                 415     


Ala Lys Pro Arg Ala Gly Ser Glu Lys Gly Ser Ala Ser Ser Arg Asp 
            420                 425                 430         


Gly Lys Thr Thr Val Trp Ile 
        435                 


<210>  4659
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  4659

Met Ala Ala Asp Gly Gln Cys Ser Leu Pro Ala Ser Trp Arg Pro Val 
1               5                   10                  15      


Thr Leu Thr His Val Glu Tyr Pro Ala Gly Asp Leu Ser Gly His Leu 
            20                  25                  30          


Leu Ala Tyr Leu Ser Leu Ser Pro Val Phe Val Ile Val Gly Phe Val 
        35                  40                  45              


Thr Leu Ile Ile Phe Lys Arg Glu Leu His Thr Ile Ser Phe Leu Gly 
    50                  55                  60                  


Gly Leu Ala Leu Asn Glu Gly Val Asn Trp Leu Ile Lys Asn Val Ile 
65                  70                  75                  80  


Gln Glu Pro Arg Pro Cys Gly Gly Pro His Thr Ala Val Gly Thr Lys 
                85                  90                  95      


Tyr Gly Met Pro Ser Ser His Ser Gln Phe Met Trp Phe Phe Ser Val 
            100                 105                 110         


Tyr Ser Phe Leu Phe Leu Tyr Leu Arg Met His Gln Thr Asn Asn Ala 
        115                 120                 125             


Arg Phe Leu Asp Leu Leu Trp Arg His Val Leu Ser Leu Gly Leu Leu 
    130                 135                 140                 


Ala Val Ala Phe Leu Val Ser Tyr Ser Arg Val Tyr Leu Leu Tyr His 
145                 150                 155                 160 


Thr Trp Ser Gln Val Leu Tyr Gly Gly Ile Ala Gly Gly Leu Met Ala 
                165                 170                 175     


Ile Ala Trp Phe Ile Phe Thr Gln Glu Val Leu Thr Pro Leu Phe Pro 
            180                 185                 190         


Arg Ile Ala Ala Trp Pro Val Ser Glu Phe Phe Leu Ile Arg Asp Thr 
        195                 200                 205             


Ser Leu Ile Pro Asn Val Leu Trp Phe Glu Tyr Thr Val Thr Arg Ala 
    210                 215                 220                 


Glu Ala Arg Asn Arg Gln Arg Lys Leu Gly Thr Lys Leu Gln 
225                 230                 235             


<210>  4660
<211>  879
<212>  PRT
<213>  Homo sapiens

<400>  4660

Met Gly Arg Leu Ala Ser Arg Pro Leu Leu Leu Ala Leu Leu Ser Leu 
1               5                   10                  15      


Ala Leu Cys Arg Gly Arg Val Val Arg Val Pro Thr Ala Thr Leu Val 
            20                  25                  30          


Arg Val Val Gly Thr Glu Leu Val Ile Pro Cys Asn Val Ser Asp Tyr 
        35                  40                  45              


Asp Gly Pro Ser Glu Gln Asn Phe Asp Trp Ser Phe Ser Ser Leu Gly 
    50                  55                  60                  


Ser Ser Phe Val Glu Leu Ala Ser Thr Trp Glu Val Gly Phe Pro Ala 
65                  70                  75                  80  


Gln Leu Tyr Gln Glu Arg Leu Gln Arg Gly Glu Ile Leu Leu Arg Arg 
                85                  90                  95      


Thr Ala Asn Asp Ala Val Glu Leu His Ile Lys Asn Val Gln Pro Ser 
            100                 105                 110         


Asp Gln Gly His Tyr Lys Cys Ser Thr Pro Ser Thr Asp Ala Thr Val 
        115                 120                 125             


Gln Gly Asn Tyr Glu Asp Thr Val Gln Val Lys Val Leu Ala Asp Ser 
    130                 135                 140                 


Leu His Val Gly Pro Ser Ala Arg Pro Pro Pro Ser Leu Ser Leu Arg 
145                 150                 155                 160 


Glu Gly Glu Pro Phe Glu Leu Arg Cys Thr Ala Ala Ser Ala Ser Pro 
                165                 170                 175     


Leu His Thr His Leu Ala Leu Leu Trp Glu Val His Arg Gly Pro Ala 
            180                 185                 190         


Arg Arg Ser Val Leu Ala Leu Thr His Glu Gly Arg Phe His Pro Gly 
        195                 200                 205             


Leu Gly Tyr Glu Gln Arg Tyr His Ser Gly Asp Val Arg Leu Asp Thr 
    210                 215                 220                 


Val Gly Ser Asp Ala Tyr Arg Leu Ser Val Ser Arg Ala Leu Ser Ala 
225                 230                 235                 240 


Asp Gln Gly Ser Tyr Arg Cys Ile Val Ser Glu Trp Ile Ala Glu Gln 
                245                 250                 255     


Gly Asn Trp Gln Glu Ile Gln Glu Lys Ala Val Glu Val Ala Thr Val 
            260                 265                 270         


Val Ile Gln Pro Ser Val Leu Arg Ala Ala Val Pro Lys Asn Val Ser 
        275                 280                 285             


Val Ala Glu Gly Lys Glu Leu Asp Leu Thr Cys Asn Ile Thr Thr Asp 
    290                 295                 300                 


Arg Ala Asp Asp Val Arg Pro Glu Val Thr Trp Ser Phe Ser Arg Met 
305                 310                 315                 320 


Pro Asp Ser Thr Leu Pro Gly Ser Arg Val Leu Ala Arg Leu Asp Arg 
                325                 330                 335     


Asp Ser Leu Val His Ser Ser Pro His Val Ala Leu Ser His Val Asp 
            340                 345                 350         


Ala Arg Ser Tyr His Leu Leu Val Arg Asp Val Ser Lys Glu Asn Ser 
        355                 360                 365             


Gly Tyr Tyr Tyr Cys His Val Ser Leu Trp Ala Pro Gly His Asn Arg 
    370                 375                 380                 


Ser Trp His Lys Val Ala Glu Ala Val Ser Ser Pro Ala Gly Val Gly 
385                 390                 395                 400 


Val Thr Trp Leu Glu Pro Asp Tyr Gln Val Tyr Leu Asn Ala Ser Lys 
                405                 410                 415     


Val Pro Gly Phe Ala Asp Asp Pro Thr Glu Leu Ala Cys Arg Val Val 
            420                 425                 430         


Asp Thr Lys Ser Gly Glu Ala Asn Val Arg Phe Thr Val Ser Trp Tyr 
        435                 440                 445             


Tyr Arg Met Asn Arg Arg Ser Asp Asn Val Val Thr Ser Glu Leu Leu 
    450                 455                 460                 


Ala Val Met Asp Gly Asp Trp Thr Leu Lys Tyr Gly Glu Arg Ser Lys 
465                 470                 475                 480 


Gln Arg Ala Gln Asp Gly Asp Phe Ile Phe Ser Lys Glu His Thr Asp 
                485                 490                 495     


Thr Phe Asn Phe Arg Ile Gln Arg Thr Thr Glu Glu Asp Arg Gly Asn 
            500                 505                 510         


Tyr Tyr Cys Val Val Ser Ala Trp Thr Lys Gln Arg Asn Asn Ser Trp 
        515                 520                 525             


Val Lys Ser Lys Asp Val Phe Ser Lys Pro Val Asn Ile Phe Trp Ala 
    530                 535                 540                 


Leu Glu Asp Ser Val Leu Val Val Lys Ala Arg Gln Pro Lys Pro Phe 
545                 550                 555                 560 


Phe Ala Ala Gly Asn Thr Phe Glu Met Thr Cys Lys Val Ser Ser Lys 
                565                 570                 575     


Asn Ile Lys Ser Pro Arg Tyr Ser Val Leu Ile Met Ala Glu Lys Pro 
            580                 585                 590         


Val Gly Asp Leu Ser Ser Pro Asn Glu Thr Lys Tyr Ile Ile Ser Leu 
        595                 600                 605             


Asp Gln Asp Ser Val Val Lys Leu Glu Asn Trp Thr Asp Ala Ser Arg 
    610                 615                 620                 


Val Asp Gly Val Val Leu Glu Lys Val Gln Glu Asp Glu Phe Arg Tyr 
625                 630                 635                 640 


Arg Met Tyr Gln Thr Gln Val Ser Asp Ala Gly Leu Tyr Arg Cys Met 
                645                 650                 655     


Val Thr Ala Trp Ser Pro Val Arg Gly Ser Leu Trp Arg Glu Ala Ala 
            660                 665                 670         


Thr Ser Leu Ser Asn Pro Ile Glu Ile Asp Phe Gln Thr Ser Gly Pro 
        675                 680                 685             


Ile Phe Asn Ala Ser Val His Ser Asp Thr Pro Ser Val Ile Arg Gly 
    690                 695                 700                 


Asp Leu Ile Lys Leu Phe Cys Ile Ile Thr Val Glu Gly Ala Ala Leu 
705                 710                 715                 720 


Asp Pro Asp Asp Met Ala Phe Asp Val Ser Trp Phe Ala Val His Ser 
                725                 730                 735     


Phe Gly Leu Asp Lys Ala Pro Val Leu Leu Ser Ser Leu Asp Arg Lys 
            740                 745                 750         


Gly Ile Val Thr Thr Ser Arg Arg Asp Trp Lys Ser Asp Leu Ser Leu 
        755                 760                 765             


Glu Arg Val Ser Val Leu Glu Phe Leu Leu Gln Val His Gly Ser Glu 
    770                 775                 780                 


Asp Gln Asp Phe Gly Asn Tyr Tyr Cys Ser Val Thr Pro Trp Val Lys 
785                 790                 795                 800 


Ser Pro Thr Gly Ser Trp Gln Lys Glu Ala Glu Ile His Ser Lys Pro 
                805                 810                 815     


Val Phe Ile Thr Val Lys Met Asp Val Leu Asn Ala Phe Lys Tyr Pro 
            820                 825                 830         


Leu Leu Ile Gly Val Gly Leu Ser Thr Val Ile Gly Leu Leu Ser Cys 
        835                 840                 845             


Leu Ile Gly Tyr Cys Ser Ser His Trp Cys Cys Lys Lys Glu Val Gln 
    850                 855                 860                 


Glu Thr Arg Arg Glu Arg Arg Arg Leu Met Ser Met Glu Met Asp 
865                 870                 875                 


<210>  4661
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  4661

Met Asp Gly Ser His Ser Ala Ala Leu Lys Leu Gln Gln Leu Pro Pro 
1               5                   10                  15      


Thr Ser Ser Ser Ser Ala Val Ser Glu Ala Ser Phe Ser Tyr Lys Glu 
            20                  25                  30          


Asn Leu Ile Gly Ala Leu Leu Ala Ile Phe Gly His Leu Val Val Ser 
        35                  40                  45              


Ile Ala Leu Asn Leu Gln Lys Tyr Cys His Ile Arg Leu Ala Gly Ser 
    50                  55                  60                  


Lys Asp Pro Arg Ala Tyr Phe Lys Thr Lys Thr Trp Trp Leu Gly Leu 
65                  70                  75                  80  


Phe Leu Met Leu Leu Gly Glu Leu Gly Val Phe Ala Ser Tyr Ala Phe 
                85                  90                  95      


Ala Pro Leu Ser Leu Ile Val Pro Leu Ser Ala Val Ser Val Ile Ala 
            100                 105                 110         


Ser Ala Ile Ile Gly Ile Ile Phe Ile Lys Glu Lys Trp Lys Pro Lys 
        115                 120                 125             


Asp Phe Leu Arg Arg Tyr Val Leu Ser Phe Val Gly Cys Gly Leu Ala 
    130                 135                 140                 


Val Val Gly Thr Tyr Leu Leu Val Thr Phe Ala Pro Asn Ser His Glu 
145                 150                 155                 160 


Lys Met Thr Gly Glu Asn Val Thr Arg His Leu Val Ser Trp Pro Phe 
                165                 170                 175     


Leu Leu Tyr Met Leu Val Glu Ile Ile Leu Phe Cys Leu Leu Leu Tyr 
            180                 185                 190         


Phe Tyr Lys Glu Lys Asn Ala Asn Asn Ile Val Val Ile Leu Leu Leu 
        195                 200                 205             


Val Ala Leu Leu Gly Ser Met Thr Val Val Thr Val Lys Ala Val Ala 
    210                 215                 220                 


Gly Met Leu Val Leu Ser Ile Gln Gly Asn Leu Gln Leu Asp Tyr Pro 
225                 230                 235                 240 


Ile Phe Tyr Val Met Phe Val Cys Met Val Ala Thr Ala Val Tyr Gln 
                245                 250                 255     


Ala Ala Phe Leu Ser Gln Ala Ser Gln Met Tyr Asp Ser Ser Leu Ile 
            260                 265                 270         


Ala Ser Val Gly Tyr Ile Leu Ser Thr Thr Ile Ala Ile Thr Ala Gly 
        275                 280                 285             


Ala Ile Phe Tyr Leu Asp Phe Ile Gly Glu Asp Val Leu His Ile Cys 
    290                 295                 300                 


Met Phe Ala Leu Gly Cys Leu Ile Ala Phe Leu Gly Val Phe Leu Ile 
305                 310                 315                 320 


Thr Arg Asn Arg Lys Lys Pro Ile Pro Phe Glu Pro Tyr Ile Ser Met 
                325                 330                 335     


Asp Ala Met Pro Gly Met Gln Asn Met His Asp Lys Gly Met Thr Val 
            340                 345                 350         


Gln Pro Glu Leu Lys Ala Ser Phe Ser Tyr Gly Ala Leu Glu Asn Asn 
        355                 360                 365             


Asp Asn Ile Ser Glu Ile Tyr Ala Pro Ala Thr Leu Pro Val Met Gln 
    370                 375                 380                 


Glu Glu His Gly Ser Arg Ser Ala Ser Gly Val Pro Tyr Arg Val Leu 
385                 390                 395                 400 


Glu His Thr Lys Lys Glu 
                405     


<210>  4662
<211>  1426
<212>  PRT
<213>  Homo sapiens

<400>  4662

Met Thr Glu Ala Leu Gln Trp Ala Arg Tyr His Trp Arg Arg Leu Ile 
1               5                   10                  15      


Arg Gly Ala Thr Arg Asp Asp Asp Ser Gly Pro Tyr Asn Tyr Ser Ser 
            20                  25                  30          


Leu Leu Ala Cys Gly Arg Lys Ser Ser Gln Thr Pro Lys Leu Ser Gly 
        35                  40                  45              


Arg His Arg Ile Val Val Pro His Ile Gln Pro Phe Lys Asp Glu Tyr 
    50                  55                  60                  


Glu Lys Phe Ser Gly Ala Tyr Val Asn Asn Arg Ile Arg Thr Thr Lys 
65                  70                  75                  80  


Tyr Thr Leu Leu Asn Phe Val Pro Arg Asn Leu Phe Glu Gln Phe His 
                85                  90                  95      


Arg Ala Ala Asn Leu Tyr Phe Leu Phe Leu Val Val Leu Asn Trp Val 
            100                 105                 110         


Pro Leu Val Glu Ala Phe Gln Lys Glu Ile Thr Met Leu Pro Leu Val 
        115                 120                 125             


Val Val Leu Thr Ile Ile Ala Ile Lys Asp Gly Leu Glu Asp Tyr Arg 
    130                 135                 140                 


Lys Tyr Lys Ile Asp Lys Gln Ile Asn Asn Leu Ile Thr Lys Val Tyr 
145                 150                 155                 160 


Ser Arg Lys Glu Lys Lys Tyr Ile Asp Arg Cys Trp Lys Asp Val Thr 
                165                 170                 175     


Val Gly Asp Phe Ile Arg Leu Ser Cys Asn Glu Val Ile Pro Ala Asp 
            180                 185                 190         


Met Val Leu Leu Phe Ser Thr Asp Pro Asp Gly Ile Cys His Ile Glu 
        195                 200                 205             


Thr Ser Gly Leu Asp Gly Glu Ser Asn Leu Lys Gln Arg Gln Val Val 
    210                 215                 220                 


Arg Gly Tyr Ala Glu Gln Asp Ser Glu Val Asp Pro Glu Lys Phe Ser 
225                 230                 235                 240 


Ser Arg Ile Glu Cys Glu Ser Pro Asn Asn Asp Leu Ser Arg Phe Arg 
                245                 250                 255     


Gly Phe Leu Glu His Ser Asn Lys Glu Arg Val Gly Leu Ser Lys Glu 
            260                 265                 270         


Asn Leu Leu Leu Arg Gly Cys Thr Ile Arg Asn Thr Glu Ala Val Val 
        275                 280                 285             


Gly Ile Val Val Tyr Ala Gly His Glu Thr Lys Ala Met Leu Asn Asn 
    290                 295                 300                 


Ser Gly Pro Arg Tyr Lys Arg Ser Lys Leu Glu Arg Arg Ala Asn Thr 
305                 310                 315                 320 


Asp Val Leu Trp Cys Val Met Leu Leu Val Ile Met Cys Leu Thr Gly 
                325                 330                 335     


Ala Val Gly His Gly Ile Trp Leu Ser Arg Tyr Glu Lys Met His Phe 
            340                 345                 350         


Phe Asn Val Pro Glu Pro Asp Gly His Ile Ile Ser Pro Leu Leu Ala 
        355                 360                 365             


Gly Phe Tyr Met Phe Trp Thr Met Ile Ile Leu Leu Gln Val Leu Ile 
    370                 375                 380                 


Pro Ile Ser Leu Tyr Val Ser Ile Glu Ile Val Lys Leu Gly Gln Ile 
385                 390                 395                 400 


Tyr Phe Ile Gln Ser Asp Val Asp Phe Tyr Asn Glu Lys Met Asp Ser 
                405                 410                 415     


Ile Val Gln Cys Arg Ala Leu Asn Ile Ala Glu Asp Leu Gly Gln Ile 
            420                 425                 430         


Gln Tyr Leu Phe Ser Asp Lys Thr Gly Thr Leu Thr Glu Asn Lys Met 
        435                 440                 445             


Val Phe Arg Arg Cys Ser Val Ala Gly Phe Asp Tyr Cys His Glu Glu 
    450                 455                 460                 


Asn Ala Arg Arg Leu Glu Ser Tyr Gln Glu Ala Val Ser Glu Asp Glu 
465                 470                 475                 480 


Asp Phe Ile Asp Thr Val Ser Gly Ser Leu Ser Asn Met Ala Lys Pro 
                485                 490                 495     


Arg Ala Pro Ser Cys Arg Thr Val His Asn Gly Pro Leu Gly Asn Lys 
            500                 505                 510         


Pro Ser Asn His Leu Ala Gly Ser Ser Phe Thr Leu Gly Ser Gly Glu 
        515                 520                 525             


Gly Ala Ser Glu Val Pro His Ser Arg Gln Ala Ala Phe Ser Ser Pro 
    530                 535                 540                 


Ile Glu Thr Asp Val Val Pro Asp Thr Arg Leu Leu Asp Lys Phe Ser 
545                 550                 555                 560 


Gln Ile Thr Pro Arg Leu Phe Met Pro Leu Asp Glu Thr Ile Gln Asn 
                565                 570                 575     


Pro Pro Met Glu Thr Leu Tyr Ile Ile Asp Phe Phe Ile Ala Leu Ala 
            580                 585                 590         


Ile Cys Asn Thr Val Val Val Ser Ala Pro Asn Gln Pro Arg Gln Lys 
        595                 600                 605             


Ile Arg His Pro Ser Leu Gly Gly Leu Pro Ile Lys Ser Leu Glu Glu 
    610                 615                 620                 


Ile Lys Ser Leu Phe Gln Arg Trp Ser Val Arg Arg Ser Ser Ser Pro 
625                 630                 635                 640 


Ser Leu Asn Ser Gly Lys Glu Pro Ser Ser Gly Val Pro Asn Ala Phe 
                645                 650                 655     


Val Ser Arg Leu Pro Leu Phe Ser Arg Met Lys Pro Ala Ser Pro Val 
            660                 665                 670         


Glu Glu Glu Val Ser Gln Val Cys Glu Ser Pro Gln Cys Ser Ser Ser 
        675                 680                 685             


Ser Ala Cys Cys Thr Glu Thr Glu Lys Gln His Gly Asp Ala Gly Leu 
    690                 695                 700                 


Leu Asn Gly Lys Ala Glu Ser Leu Pro Gly Gln Pro Leu Ala Cys Asn 
705                 710                 715                 720 


Leu Cys Tyr Glu Ala Glu Ser Pro Asp Glu Ala Ala Leu Val Tyr Ala 
                725                 730                 735     


Ala Arg Ala Tyr Gln Cys Thr Leu Arg Ser Arg Thr Pro Glu Gln Val 
            740                 745                 750         


Met Val Asp Phe Ala Ala Leu Gly Pro Leu Thr Phe Gln Leu Leu His 
        755                 760                 765             


Ile Leu Pro Phe Asp Ser Val Arg Lys Arg Met Ser Val Val Val Arg 
    770                 775                 780                 


His Pro Leu Ser Asn Gln Val Val Val Tyr Thr Lys Gly Ala Asp Ser 
785                 790                 795                 800 


Val Ile Met Glu Leu Leu Ser Val Ala Ser Pro Asp Gly Ala Ser Leu 
                805                 810                 815     


Glu Lys Gln Gln Met Ile Val Arg Glu Lys Thr Gln Lys His Leu Asp 
            820                 825                 830         


Asp Tyr Ala Lys Gln Gly Leu Arg Thr Leu Cys Ile Ala Lys Lys Val 
        835                 840                 845             


Met Ser Asp Thr Glu Tyr Ala Glu Trp Leu Arg Asn His Phe Leu Ala 
    850                 855                 860                 


Glu Thr Ser Ile Asp Asn Arg Glu Glu Leu Leu Leu Glu Ser Ala Met 
865                 870                 875                 880 


Arg Leu Glu Asn Lys Leu Thr Leu Leu Gly Ala Thr Gly Ile Glu Asp 
                885                 890                 895     


Arg Leu Gln Glu Gly Val Pro Glu Ser Ile Glu Ala Leu His Lys Ala 
            900                 905                 910         


Gly Ile Lys Ile Trp Met Leu Thr Gly Asp Lys Gln Glu Thr Ala Val 
        915                 920                 925             


Asn Ile Ala Tyr Ala Cys Lys Leu Leu Glu Pro Asp Asp Lys Leu Phe 
    930                 935                 940                 


Ile Leu Asn Thr Gln Ser Lys Asp Ala Cys Gly Met Leu Met Ser Thr 
945                 950                 955                 960 


Ile Leu Lys Glu Leu Gln Lys Lys Thr Gln Ala Leu Pro Glu Gln Val 
                965                 970                 975     


Ser Leu Ser Glu Asp Leu Leu Gln Pro Pro Val Pro Arg Asp Ser Gly 
            980                 985                 990         


Leu Arg Ala Gly Leu Ile Ile Thr  Gly Lys Thr Leu Glu  Phe Ala Leu 
        995                 1000                 1005             


Gln Glu  Ser Leu Gln Lys Gln  Phe Leu Glu Leu Thr  Ser Trp Cys 
    1010                 1015                 1020             


Gln Ala  Val Val Cys Cys Arg  Ala Thr Pro Leu Gln  Lys Ser Glu 
    1025                 1030                 1035             


Val Val  Lys Leu Val Arg Ser  His Leu Gln Val Met  Thr Leu Ala 
    1040                 1045                 1050             


Ile Gly  Asp Gly Ala Asn Asp  Val Ser Met Ile Gln  Val Ala Asp 
    1055                 1060                 1065             


Ile Gly  Ile Gly Val Ser Gly  Gln Glu Gly Met Gln  Ala Val Met 
    1070                 1075                 1080             


Ala Ser  Asp Phe Ala Val Ser  Gln Phe Lys His Leu  Ser Lys Leu 
    1085                 1090                 1095             


Leu Leu  Val His Gly His Trp  Cys Tyr Thr Arg Leu  Ser Asn Met 
    1100                 1105                 1110             


Ile Leu  Tyr Phe Phe Tyr Lys  Asn Val Ala Tyr Val  Asn Leu Leu 
    1115                 1120                 1125             


Phe Trp  Tyr Gln Phe Phe Cys  Gly Phe Ser Gly Thr  Ser Met Thr 
    1130                 1135                 1140             


Asp Tyr  Trp Val Leu Ile Phe  Phe Asn Leu Leu Phe  Thr Ser Ala 
    1145                 1150                 1155             


Pro Pro  Val Ile Tyr Gly Val  Leu Glu Lys Asp Val  Ser Ala Glu 
    1160                 1165                 1170             


Thr Leu  Met Gln Leu Pro Glu  Leu Tyr Arg Ser Gly  Gln Lys Ser 
    1175                 1180                 1185             


Glu Ala  Tyr Leu Pro His Thr  Phe Trp Ile Thr Leu  Leu Asp Ala 
    1190                 1195                 1200             


Phe Tyr  Gln Ser Leu Val Cys  Phe Phe Val Pro Tyr  Phe Thr Tyr 
    1205                 1210                 1215             


Gln Gly  Ser Asp Thr Asp Ile  Phe Ala Phe Gly Asn  Pro Leu Asn 
    1220                 1225                 1230             


Thr Ala  Ala Leu Phe Ile Val  Leu Leu His Leu Val  Ile Glu Ser 
    1235                 1240                 1245             


Lys Ser  Leu Thr Trp Ile His  Leu Leu Val Ile Ile  Gly Ser Ile 
    1250                 1255                 1260             


Leu Ser  Tyr Phe Leu Phe Ala  Ile Val Phe Gly Ala  Met Cys Val 
    1265                 1270                 1275             


Thr Cys  Asn Pro Pro Ser Asn  Pro Tyr Trp Ile Met  Gln Glu His 
    1280                 1285                 1290             


Met Leu  Asp Pro Val Phe Tyr  Leu Val Cys Ile Leu  Thr Thr Ser 
    1295                 1300                 1305             


Ile Ala  Leu Leu Pro Arg Phe  Val Tyr Arg Val Leu  Gln Gly Ser 
    1310                 1315                 1320             


Leu Phe  Pro Ser Pro Ile Leu  Arg Ala Lys His Phe  Asp Arg Leu 
    1325                 1330                 1335             


Thr Pro  Glu Glu Arg Thr Lys  Ala Leu Lys Lys Trp  Arg Gly Ala 
    1340                 1345                 1350             


Gly Lys  Met Asn Gln Val Thr  Ser Lys Tyr Ala Asn  Gln Ser Ala 
    1355                 1360                 1365             


Gly Lys  Ser Gly Arg Arg Pro  Met Pro Gly Pro Ser  Ala Val Phe 
    1370                 1375                 1380             


Ala Met  Lys Ser Ala Ser Ser  Cys Ala Ile Glu Gln  Gly Asn Leu 
    1385                 1390                 1395             


Ser Leu  Cys Glu Thr Ala Leu  Asp Gln Gly Tyr Ser  Glu Thr Lys 
    1400                 1405                 1410             


Ala Phe  Glu Met Ala Gly Pro  Ser Lys Gly Lys Glu  Ser 
    1415                 1420                 1425     


<210>  4663
<211>  1221
<212>  PRT
<213>  Homo sapiens

<400>  4663

Met Met Phe Arg Ser Asp Arg Met Trp Ser Cys His Trp Lys Trp Lys 
1               5                   10                  15      


Pro Ser Pro Leu Leu Phe Leu Phe Ala Leu Tyr Ile Met Cys Val Pro 
            20                  25                  30          


His Ser Val Trp Gly Cys Ala Asn Cys Arg Val Val Leu Ser Asn Pro 
        35                  40                  45              


Ser Gly Thr Phe Thr Ser Pro Cys Tyr Pro Asn Asp Tyr Pro Asn Ser 
    50                  55                  60                  


Gln Ala Cys Met Trp Thr Leu Arg Ala Pro Thr Gly Tyr Ile Ile Gln 
65                  70                  75                  80  


Ile Thr Phe Asn Asp Phe Asp Ile Glu Glu Ala Pro Asn Cys Ile Tyr 
                85                  90                  95      


Asp Ser Leu Ser Leu Asp Asn Gly Glu Ser Gln Thr Lys Phe Cys Gly 
            100                 105                 110         


Ala Thr Ala Lys Gly Leu Ser Phe Asn Ser Ser Ala Asn Glu Met His 
        115                 120                 125             


Val Ser Phe Ser Ser Asp Phe Ser Ile Gln Lys Lys Gly Phe Asn Ala 
    130                 135                 140                 


Ser Tyr Ile Arg Val Ala Val Ser Leu Arg Asn Gln Lys Val Ile Leu 
145                 150                 155                 160 


Pro Gln Thr Ser Asp Ala Tyr Gln Val Ser Val Ala Lys Ser Ile Ser 
                165                 170                 175     


Ile Pro Glu Leu Ser Ala Phe Thr Leu Cys Phe Glu Ala Thr Lys Val 
            180                 185                 190         


Gly His Glu Asp Ser Asp Trp Thr Ala Phe Ser Tyr Ser Asn Ala Ser 
        195                 200                 205             


Phe Thr Gln Leu Leu Ser Phe Gly Lys Ala Lys Ser Gly Tyr Phe Leu 
    210                 215                 220                 


Ser Ile Ser Asp Ser Lys Cys Leu Leu Asn Asn Ala Leu Pro Val Lys 
225                 230                 235                 240 


Glu Lys Glu Asp Ile Phe Ala Glu Ser Phe Glu Gln Leu Cys Leu Val 
                245                 250                 255     


Trp Asn Asn Ser Leu Gly Ser Ile Gly Val Asn Phe Lys Arg Asn Tyr 
            260                 265                 270         


Glu Thr Val Pro Cys Asp Ser Thr Ile Ser Lys Val Ile Pro Gly Asn 
        275                 280                 285             


Gly Lys Leu Leu Leu Gly Ser Asn Gln Asn Glu Ile Val Ser Leu Lys 
    290                 295                 300                 


Gly Asp Ile Tyr Asn Phe Arg Leu Trp Asn Phe Thr Met Asn Ala Lys 
305                 310                 315                 320 


Ile Leu Ser Asn Leu Ser Cys Asn Val Lys Gly Asn Val Val Asp Trp 
                325                 330                 335     


Gln Asn Asp Phe Trp Asn Ile Pro Asn Leu Ala Leu Lys Ala Glu Ser 
            340                 345                 350         


Asn Leu Ser Cys Gly Ser Tyr Leu Ile Pro Leu Pro Ala Ala Glu Leu 
        355                 360                 365             


Ala Ser Cys Ala Asp Leu Gly Thr Leu Cys Gln Ala Thr Val Asn Ser 
    370                 375                 380                 


Pro Ser Thr Thr Pro Pro Thr Val Thr Thr Asn Met Pro Val Thr Asn 
385                 390                 395                 400 


Arg Ile Asp Lys Gln Arg Asn Asp Gly Ile Ile Tyr Arg Ile Ser Val 
                405                 410                 415     


Val Ile Gln Asn Ile Leu Arg His Pro Glu Val Lys Val Gln Ser Lys 
            420                 425                 430         


Val Ala Glu Trp Leu Asn Ser Thr Phe Gln Asn Trp Asn Tyr Thr Val 
        435                 440                 445             


Tyr Val Val Asn Ile Ser Phe His Leu Ser Ala Gly Glu Asp Lys Ile 
    450                 455                 460                 


Lys Val Lys Arg Ser Leu Glu Asp Glu Pro Arg Leu Val Leu Trp Ala 
465                 470                 475                 480 


Leu Leu Val Tyr Asn Ala Thr Asn Asn Thr Asn Leu Glu Gly Lys Ile 
                485                 490                 495     


Ile Gln Gln Lys Leu Leu Lys Asn Asn Glu Ser Leu Asp Glu Gly Leu 
            500                 505                 510         


Arg Leu His Thr Val Asn Val Arg Gln Leu Gly His Cys Leu Ala Met 
        515                 520                 525             


Glu Glu Pro Lys Gly Tyr Tyr Trp Pro Ser Ile Gln Pro Ser Glu Tyr 
    530                 535                 540                 


Val Leu Pro Cys Pro Asp Lys Pro Gly Phe Ser Ala Ser Arg Ile Cys 
545                 550                 555                 560 


Phe Tyr Asn Ala Thr Asn Pro Leu Val Thr Tyr Trp Gly Pro Val Asp 
                565                 570                 575     


Ile Ser Asn Cys Leu Lys Glu Ala Asn Glu Val Ala Asn Gln Ile Leu 
            580                 585                 590         


Asn Leu Thr Ala Asp Gly Gln Asn Leu Thr Ser Ala Asn Ile Thr Asn 
        595                 600                 605             


Ile Val Glu Gln Val Lys Arg Ile Val Asn Lys Glu Glu Asn Ile Asp 
    610                 615                 620                 


Ile Thr Leu Gly Ser Thr Leu Met Asn Ile Phe Ser Asn Ile Leu Ser 
625                 630                 635                 640 


Ser Ser Asp Ser Asp Leu Leu Glu Ser Ser Ser Glu Ala Leu Lys Thr 
                645                 650                 655     


Ile Asp Glu Leu Ala Phe Lys Ile Asp Leu Asn Ser Thr Ser His Val 
            660                 665                 670         


Asn Ile Thr Thr Arg Asn Leu Ala Leu Ser Val Ser Ser Leu Leu Pro 
        675                 680                 685             


Gly Thr Asn Ala Ile Ser Asn Phe Ser Ile Gly Leu Pro Ser Asn Asn 
    690                 695                 700                 


Glu Ser Tyr Phe Gln Met Asp Phe Glu Ser Gly Gln Val Asp Pro Leu 
705                 710                 715                 720 


Ala Ser Val Ile Leu Pro Pro Asn Leu Leu Glu Asn Leu Ser Pro Glu 
                725                 730                 735     


Asp Ser Val Leu Val Arg Arg Ala Gln Phe Thr Phe Phe Asn Lys Thr 
            740                 745                 750         


Gly Leu Phe Gln Asp Val Gly Pro Gln Arg Lys Thr Leu Val Ser Tyr 
        755                 760                 765             


Val Met Ala Cys Ser Ile Gly Asn Ile Thr Ile Gln Asn Leu Lys Asp 
    770                 775                 780                 


Pro Val Gln Ile Lys Ile Lys His Thr Arg Thr Gln Glu Val His His 
785                 790                 795                 800 


Pro Ile Cys Ala Phe Trp Asp Leu Asn Lys Asn Lys Ser Phe Gly Gly 
                805                 810                 815     


Trp Asn Thr Ser Gly Cys Val Ala His Arg Asp Ser Asp Ala Ser Glu 
            820                 825                 830         


Thr Val Cys Leu Cys Asn His Phe Thr His Phe Gly Val Leu Met Asp 
        835                 840                 845             


Leu Pro Arg Ser Ala Ser Gln Leu Asp Ala Arg Asn Thr Lys Val Leu 
    850                 855                 860                 


Thr Phe Ile Ser Tyr Ile Gly Cys Gly Ile Ser Ala Ile Phe Ser Ala 
865                 870                 875                 880 


Ala Thr Leu Leu Thr Tyr Val Ala Phe Glu Lys Leu Arg Arg Asp Tyr 
                885                 890                 895     


Pro Ser Lys Ile Leu Met Asn Leu Ser Thr Ala Leu Leu Phe Leu Asn 
            900                 905                 910         


Leu Leu Phe Leu Leu Asp Gly Trp Ile Thr Ser Phe Asn Val Asp Gly 
        915                 920                 925             


Leu Cys Ile Ala Val Ala Val Leu Leu His Phe Phe Leu Leu Ala Thr 
    930                 935                 940                 


Phe Thr Trp Met Gly Leu Glu Ala Ile His Met Tyr Ile Ala Leu Val 
945                 950                 955                 960 


Lys Val Phe Asn Thr Tyr Ile Arg Arg Tyr Ile Leu Lys Phe Cys Ile 
                965                 970                 975     


Ile Gly Trp Gly Leu Pro Ala Leu Val Val Ser Val Val Leu Ala Ser 
            980                 985                 990         


Arg Asn Asn Asn Glu Val Tyr Gly  Lys Glu Ser Tyr Gly  Lys Glu Lys 
        995                 1000                 1005             


Gly Asp  Glu Phe Cys Trp Ile  Gln Asp Pro Val Ile  Phe Tyr Val 
    1010                 1015                 1020             


Thr Cys  Ala Gly Tyr Phe Gly  Val Met Phe Phe Leu  Asn Ile Ala 
    1025                 1030                 1035             


Met Phe  Ile Val Val Met Val  Gln Ile Cys Gly Arg  Asn Gly Lys 
    1040                 1045                 1050             


Arg Ser  Asn Arg Thr Leu Arg  Glu Glu Val Leu Arg  Asn Leu Arg 
    1055                 1060                 1065             


Ser Val  Val Ser Leu Thr Phe  Leu Leu Gly Met Thr  Trp Gly Phe 
    1070                 1075                 1080             


Ala Phe  Phe Ala Trp Gly Pro  Leu Asn Ile Pro Phe  Met Tyr Leu 
    1085                 1090                 1095             


Phe Ser  Ile Phe Asn Ser Leu  Gln Gly Leu Phe Ile  Phe Ile Phe 
    1100                 1105                 1110             


His Cys  Ala Met Lys Glu Asn  Val Gln Lys Gln Trp  Arg Arg His 
    1115                 1120                 1125             


Leu Cys  Cys Gly Arg Phe Arg  Leu Ala Asp Asn Ser  Asp Trp Ser 
    1130                 1135                 1140             


Lys Thr  Ala Thr Asn Ile Ile  Lys Lys Ser Ser Asp  Asn Leu Gly 
    1145                 1150                 1155             


Lys Ser  Leu Ser Ser Ser Ser  Ile Gly Ser Asn Ser  Thr Tyr Leu 
    1160                 1165                 1170             


Thr Ser  Lys Ser Lys Ser Ser  Ser Thr Thr Tyr Phe  Lys Arg Asn 
    1175                 1180                 1185             


Ser His  Thr Asp Asn Val Ser  Tyr Glu His Ser Phe  Asn Lys Ser 
    1190                 1195                 1200             


Gly Ser  Leu Arg Gln Cys Phe  His Gly Gln Val Leu  Val Lys Thr 
    1205                 1210                 1215             


Gly Pro  Cys 
    1220     


<210>  4664
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  4664

Met Ala Gly Leu Gln Glu Leu Arg Phe Pro Glu Glu Lys Pro Leu Leu 
1               5                   10                  15      


Arg Gly Gln Asp Ala Thr Glu Leu Glu Ser Ser Asp Ala Phe Leu Leu 
            20                  25                  30          


Ala Ala Asp Thr Asp Trp Lys Glu His Asp Ile Glu Thr Pro Tyr Gly 
        35                  40                  45              


Leu Leu His Val Val Ile Arg Gly Ser Pro Lys Gly Asn Arg Pro Ala 
    50                  55                  60                  


Ile Leu Thr Tyr His Asp Val Gly Leu Asn His Lys Leu Cys Phe Asn 
65                  70                  75                  80  


Thr Phe Phe Asn Phe Glu Asp Met Gln Glu Ile Thr Lys His Phe Val 
                85                  90                  95      


Val Cys His Val Asp Ala Pro Gly Gln Gln Val Gly Ala Ser Gln Phe 
            100                 105                 110         


Pro Gln Gly Tyr Gln Phe Pro Ser Met Glu Gln Leu Ala Ala Met Leu 
        115                 120                 125             


Pro Ser Val Val Gln His Phe Gly Phe Lys Tyr Val Ile Gly Ile Gly 
    130                 135                 140                 


Val Gly Ala Gly Ala Tyr Val Leu Ala Lys Phe Ala Leu Ile Phe Pro 
145                 150                 155                 160 


Asp Leu Val Glu Gly Leu Val Leu Val Asn Ile Asp Pro Asn Gly Lys 
                165                 170                 175     


Gly Trp Ile Asp Trp Ala Ala Thr Lys Leu Ser Gly Leu Thr Ser Thr 
            180                 185                 190         


Leu Pro Asp Thr Val Leu Ser His Leu Phe Ser Gln Glu Glu Leu Val 
        195                 200                 205             


Asn Asn Thr Glu Leu Val Gln Ser Tyr Arg Gln Gln Ile Gly Asn Val 
    210                 215                 220                 


Val Asn Gln Ala Asn Leu Gln Leu Phe Trp Asn Met Tyr Asn Ser Arg 
225                 230                 235                 240 


Arg Asp Leu Asp Ile Asn Arg Pro Gly Thr Val Pro Asn Ala Lys Thr 
                245                 250                 255     


Leu Arg Cys Pro Val Met Leu Val Val Gly Asp Asn Ala Pro Ala Glu 
            260                 265                 270         


Asp Gly Val Val Glu Cys Asn Ser Lys Leu Asp Pro Thr Thr Thr Thr 
        275                 280                 285             


Phe Leu Lys Met Ala Asp Ser Gly Gly Leu Pro Gln Val Thr Gln Pro 
    290                 295                 300                 


Gly Lys Leu Thr Glu Ala Phe Lys Tyr Phe Leu Gln Gly Met Gly Tyr 
305                 310                 315                 320 


Met Pro Ser Ala Ser Met Thr Arg Leu Ala Arg Ser Arg Thr Ala Ser 
                325                 330                 335     


Leu Thr Ser Ala Ser Ser Val Asp Gly Ser Arg Pro Gln Ala Cys Thr 
            340                 345                 350         


His Ser Glu Ser Ser Glu Gly Leu Gly Gln Val Asn His Thr Met Glu 
        355                 360                 365             


Val Ser Cys 
    370     


<210>  4665
<211>  893
<212>  PRT
<213>  Homo sapiens

<400>  4665

Met Val Pro Trp Val Arg Thr Met Gly Gln Lys Leu Lys Gln Arg Leu 
1               5                   10                  15      


Arg Leu Asp Val Gly Arg Glu Ile Cys Arg Gln Tyr Pro Leu Phe Cys 
            20                  25                  30          


Phe Leu Leu Leu Cys Leu Ser Ala Ala Ser Leu Leu Leu Asn Arg Tyr 
        35                  40                  45              


Ile His Ile Leu Met Ile Phe Trp Ser Phe Val Ala Gly Val Val Thr 
    50                  55                  60                  


Phe Tyr Cys Ser Leu Gly Pro Asp Ser Leu Leu Pro Asn Ile Phe Phe 
65                  70                  75                  80  


Thr Ile Lys Tyr Lys Pro Lys Gln Leu Gly Leu Gln Glu Leu Phe Pro 
                85                  90                  95      


Gln Gly His Ser Cys Ala Val Cys Gly Lys Val Lys Cys Lys Arg His 
            100                 105                 110         


Arg Pro Ser Leu Leu Leu Glu Asn Tyr Gln Pro Trp Leu Asp Leu Lys 
        115                 120                 125             


Ile Ser Ser Lys Val Asp Ala Ser Leu Ser Glu Val Asp Ile Pro Ser 
    130                 135                 140                 


Ile Ile Thr Lys Lys Leu Leu Lys Ala Ala Met Lys His Ile Glu Val 
145                 150                 155                 160 


Ile Val Lys Ala Arg Gln Lys Val Lys Asn Thr Glu Phe Leu Gln Gln 
                165                 170                 175     


Ala Ala Leu Glu Glu Tyr Gly Pro Glu Leu His Val Ala Leu Arg Ser 
            180                 185                 190         


Arg Arg Asp Glu Leu His Tyr Leu Arg Lys Leu Thr Glu Leu Leu Phe 
        195                 200                 205             


Pro Tyr Ile Leu Pro Pro Lys Ala Thr Asp Cys Arg Ser Leu Thr Leu 
    210                 215                 220                 


Leu Ile Arg Glu Ile Leu Ser Gly Ser Val Phe Leu Pro Ser Leu Asp 
225                 230                 235                 240 


Phe Leu Ala Asp Pro Asp Thr Val Asn His Leu Leu Ile Ile Phe Ile 
                245                 250                 255     


Asp Asp Ser Pro Pro Glu Lys Ala Thr Glu Pro Ala Ser Pro Leu Val 
            260                 265                 270         


Pro Phe Leu Gln Lys Phe Ala Glu Pro Arg Asn Lys Lys Pro Ser Val 
        275                 280                 285             


Leu Lys Leu Glu Leu Lys Gln Ile Arg Glu Gln Gln Asp Leu Leu Phe 
    290                 295                 300                 


Arg Phe Met Asn Phe Leu Lys Gln Glu Gly Ala Val His Val Leu Gln 
305                 310                 315                 320 


Phe Cys Leu Thr Val Glu Glu Phe Asn Asp Arg Ile Leu Arg Pro Glu 
                325                 330                 335     


Leu Ser Asn Asp Glu Met Leu Ser Leu His Glu Glu Leu Gln Lys Ile 
            340                 345                 350         


Tyr Lys Thr Tyr Cys Leu Asp Glu Ser Ile Asp Lys Ile Arg Phe Asp 
        355                 360                 365             


Pro Phe Ile Val Glu Glu Ile Gln Arg Ile Ala Glu Gly Pro Tyr Ile 
    370                 375                 380                 


Asp Val Val Lys Leu Gln Thr Met Arg Cys Leu Phe Glu Ala Tyr Glu 
385                 390                 395                 400 


His Val Leu Ser Leu Leu Glu Asn Val Phe Thr Pro Met Phe Cys His 
                405                 410                 415     


Ser Asp Glu Tyr Phe Arg Gln Leu Leu Arg Gly Ala Glu Ser Pro Thr 
            420                 425                 430         


Arg Asn Ser Lys Leu Asn Arg Asn Thr Gln Lys Arg Gly Glu Ser Phe 
        435                 440                 445             


Gly Ile Ser Arg Ile Gly Ser Lys Ile Lys Gly Val Phe Lys Ser Thr 
    450                 455                 460                 


Thr Met Glu Gly Ala Met Leu Pro Asn Tyr Gly Val Ala Glu Gly Glu 
465                 470                 475                 480 


Asp Asp Phe Ile Glu Glu Gly Ile Val Val Met Glu Asp Asp Ser Pro 
                485                 490                 495     


Val Glu Ala Val Ser Thr Pro Asn Thr Pro Arg Asn Leu Ala Ala Trp 
            500                 505                 510         


Lys Ile Ser Ile Pro Tyr Val Asp Phe Phe Glu Asp Pro Ser Ser Glu 
        515                 520                 525             


Arg Lys Glu Lys Lys Glu Arg Ile Pro Val Phe Cys Ile Asp Val Glu 
    530                 535                 540                 


Arg Asn Asp Arg Arg Ala Val Gly His Glu Pro Glu His Trp Ser Val 
545                 550                 555                 560 


Tyr Arg Arg Tyr Leu Glu Phe Tyr Val Leu Glu Ser Lys Leu Thr Glu 
                565                 570                 575     


Phe His Gly Ala Phe Pro Asp Ala Gln Leu Pro Ser Lys Arg Ile Ile 
            580                 585                 590         


Gly Pro Lys Asn Tyr Glu Phe Leu Lys Ser Lys Arg Glu Glu Phe Gln 
        595                 600                 605             


Glu Tyr Leu Gln Lys Leu Leu Gln His Pro Glu Leu Ser Asn Ser Gln 
    610                 615                 620                 


Leu Leu Ala Asp Phe Leu Ser Pro Asn Gly Gly Glu Thr Gln Phe Leu 
625                 630                 635                 640 


Asp Lys Ile Leu Pro Asp Val Asn Leu Gly Lys Ile Ile Lys Ser Val 
                645                 650                 655     


Pro Gly Lys Leu Met Lys Glu Lys Gly Gln His Leu Glu Pro Phe Ile 
            660                 665                 670         


Met Asn Phe Ile Asn Ser Cys Glu Ser Pro Lys Pro Lys Pro Ser Arg 
        675                 680                 685             


Pro Glu Leu Thr Ile Leu Ser Pro Thr Ser Glu Asn Asn Lys Lys Leu 
    690                 695                 700                 


Phe Asn Asp Leu Phe Lys Asn Asn Ala Asn Arg Ala Glu Asn Thr Glu 
705                 710                 715                 720 


Arg Lys Gln Asn Gln Asn Tyr Phe Met Glu Val Met Thr Val Glu Gly 
                725                 730                 735     


Val Tyr Asp Tyr Leu Met Tyr Val Gly Arg Val Val Phe Gln Val Pro 
            740                 745                 750         


Asp Trp Leu His His Leu Leu Met Gly Thr Arg Ile Leu Phe Lys Asn 
        755                 760                 765             


Thr Leu Glu Met Tyr Thr Asp Tyr Tyr Leu Gln Cys Lys Leu Glu Gln 
    770                 775                 780                 


Leu Phe Gln Glu His Arg Leu Val Ser Leu Ile Thr Leu Leu Arg Asp 
785                 790                 795                 800 


Ala Ile Phe Cys Glu Asn Thr Glu Pro Arg Ser Leu Gln Asp Lys Gln 
                805                 810                 815     


Lys Gly Ala Lys Gln Thr Phe Glu Glu Met Met Asn Tyr Ile Pro Asp 
            820                 825                 830         


Leu Leu Val Lys Cys Ile Gly Glu Glu Thr Lys Tyr Glu Ser Ile Arg 
        835                 840                 845             


Leu Leu Phe Asp Gly Leu Gln Gln Pro Val Leu Asn Lys Gln Leu Thr 
    850                 855                 860                 


Tyr Val Leu Leu Asp Ile Val Ile Gln Glu Leu Phe Pro Glu Leu Asn 
865                 870                 875                 880 


Lys Val Gln Lys Glu Val Thr Ser Val Thr Ser Trp Met 
                885                 890             


<210>  4666
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  4666

Met Ala Glu Val Leu Arg Thr Leu Ala Gly Lys Pro Lys Cys His Ala 
1               5                   10                  15      


Leu Arg Pro Met Ile Leu Phe Leu Ile Met Leu Val Leu Val Leu Phe 
            20                  25                  30          


Gly Tyr Gly Val Leu Ser Pro Arg Ser Leu Met Pro Gly Ser Leu Glu 
        35                  40                  45              


Arg Gly Phe Cys Met Ala Val Arg Glu Pro Asp His Leu Gln Arg Val 
    50                  55                  60                  


Ser Leu Pro Arg Met Val Tyr Pro Gln Pro Lys Val Leu Thr Pro Cys 
65                  70                  75                  80  


Arg Lys Asp Val Leu Val Val Thr Pro Trp Leu Ala Pro Ile Val Trp 
                85                  90                  95      


Glu Gly Thr Phe Asn Ile Asp Ile Leu Asn Glu Gln Phe Arg Leu Gln 
            100                 105                 110         


Asn Thr Thr Ile Gly Leu Thr Val Phe Ala Ile Lys Lys Tyr Val Ala 
        115                 120                 125             


Phe Leu Lys Leu Phe Leu Glu Thr Ala Glu Lys His Phe Met Val Gly 
    130                 135                 140                 


His Arg Val His Tyr Tyr Val Phe Thr Asp Gln Pro Ala Ala Val Pro 
145                 150                 155                 160 


Arg Val Thr Leu Gly Thr Gly Arg Gln Leu Ser Val Leu Glu Val Arg 
                165                 170                 175     


Ala Tyr Lys Arg Trp Gln Asp Val Ser Met Arg Arg Met Glu Met Ile 
            180                 185                 190         


Ser Asp Phe Cys Glu Arg Arg Phe Leu Ser Glu Val Asp Tyr Leu Val 
        195                 200                 205             


Cys Val Asp Val Asp Met Glu Phe Arg Asp His Val Gly Val Glu Ile 
    210                 215                 220                 


Leu Thr Pro Leu Phe Gly Thr Leu His Pro Gly Phe Tyr Gly Ser Ser 
225                 230                 235                 240 


Arg Glu Ala Phe Thr Tyr Glu Arg Arg Pro Gln Ser Gln Ala Tyr Ile 
                245                 250                 255     


Pro Lys Asp Glu Gly Asp Phe Tyr Tyr Leu Gly Gly Phe Phe Gly Gly 
            260                 265                 270         


Ser Val Gln Glu Val Gln Arg Leu Thr Arg Ala Cys His Gln Ala Met 
        275                 280                 285             


Met Val Asp Gln Ala Asn Gly Ile Glu Ala Val Trp His Asp Glu Ser 
    290                 295                 300                 


His Leu Asn Lys Tyr Leu Leu Arg His Lys Pro Thr Lys Val Leu Ser 
305                 310                 315                 320 


Pro Glu Tyr Leu Trp Asp Gln Gln Leu Leu Gly Trp Pro Ala Val Leu 
                325                 330                 335     


Arg Lys Leu Arg Phe Thr Ala Val Pro Lys Asn His Gln Ala Val Arg 
            340                 345                 350         


Asn Pro 
        


<210>  4667
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  4667

Met Ala Tyr His Ser Gly Tyr Gly Ala His Gly Ser Lys His Arg Ala 
1               5                   10                  15      


Arg Ala Ala Pro Asp Pro Pro Pro Leu Phe Asp Asp Thr Ser Gly Gly 
            20                  25                  30          


Tyr Ser Ser Gln Pro Gly Gly Tyr Pro Ala Thr Gly Ala Asp Val Ala 
        35                  40                  45              


Phe Ser Val Asn His Leu Leu Gly Asp Pro Met Ala Asn Val Ala Met 
    50                  55                  60                  


Ala Tyr Gly Ser Ser Ile Ala Ser His Gly Lys Asp Met Val His Lys 
65                  70                  75                  80  


Glu Leu His Arg Phe Val Ser Val Ser Lys Leu Lys Tyr Phe Phe Ala 
                85                  90                  95      


Val Asp Thr Ala Tyr Val Ala Lys Lys Leu Gly Leu Leu Val Phe Pro 
            100                 105                 110         


Tyr Thr His Gln Asn Trp Glu Val Gln Tyr Ser Arg Asp Ala Pro Leu 
        115                 120                 125             


Pro Pro Arg Gln Asp Leu Asn Ala Pro Asp Leu Tyr Ile Pro Thr Met 
    130                 135                 140                 


Ala Phe Ile Thr Tyr Val Leu Leu Ala Gly Met Ala Leu Gly Ile Gln 
145                 150                 155                 160 


Lys Arg Phe Ser Pro Glu Val Leu Gly Leu Cys Ala Ser Thr Ala Leu 
                165                 170                 175     


Val Trp Val Val Met Glu Val Leu Ala Leu Leu Leu Gly Leu Tyr Leu 
            180                 185                 190         


Ala Thr Val Arg Ser Asp Leu Ser Thr Phe His Leu Leu Ala Tyr Ser 
        195                 200                 205             


Gly Tyr Lys Tyr Val Gly Met Ile Leu Ser Val Leu Thr Gly Leu Leu 
    210                 215                 220                 


Phe Gly Ser Asp Gly Tyr Tyr Val Ala Leu Ala Trp Thr Ser Ser Ala 
225                 230                 235                 240 


Leu Met Tyr Phe Ile Val Arg Ser Leu Arg Thr Ala Ala Leu Gly Pro 
                245                 250                 255     


Asp Ser Met Gly Gly Pro Val Pro Arg Gln Arg Leu Gln Leu Tyr Leu 
            260                 265                 270         


Thr Leu Gly Ala Ala Ala Phe Gln Pro Leu Ile Ile Tyr Trp Leu Thr 
        275                 280                 285             


Phe His Leu Val Arg 
    290             


<210>  4668
<211>  561
<212>  PRT
<213>  Homo sapiens

<400>  4668

Met Arg Arg Phe Val Tyr Cys Lys Val Val Leu Ala Thr Ser Leu Met 
1               5                   10                  15      


Trp Val Leu Val Asp Val Phe Leu Leu Leu Tyr Phe Ser Glu Cys Asn 
            20                  25                  30          


Lys Cys Asp Asp Lys Lys Glu Arg Ser Leu Leu Pro Ala Leu Arg Ala 
        35                  40                  45              


Val Ile Ser Arg Asn Gln Glu Gly Pro Gly Glu Met Gly Lys Ala Val 
    50                  55                  60                  


Leu Ile Pro Lys Asp Asp Gln Glu Lys Met Lys Glu Leu Phe Lys Ile 
65                  70                  75                  80  


Asn Gln Phe Asn Leu Met Ala Ser Asp Leu Ile Ala Leu Asn Arg Ser 
                85                  90                  95      


Leu Pro Asp Val Arg Leu Glu Gly Cys Lys Thr Lys Val Tyr Pro Asp 
            100                 105                 110         


Glu Leu Pro Asn Thr Ser Val Val Ile Val Phe His Asn Glu Ala Trp 
        115                 120                 125             


Ser Thr Leu Leu Arg Thr Val Tyr Ser Val Ile Asn Arg Ser Pro His 
    130                 135                 140                 


Tyr Leu Leu Ser Glu Val Ile Leu Val Asp Asp Ala Ser Glu Arg Asp 
145                 150                 155                 160 


Phe Leu Lys Leu Thr Leu Glu Asn Tyr Val Lys Asn Leu Glu Val Pro 
                165                 170                 175     


Val Lys Ile Ile Arg Met Glu Glu Arg Ser Gly Leu Ile Arg Ala Arg 
            180                 185                 190         


Leu Arg Gly Ala Ala Ala Ser Lys Gly Gln Val Ile Thr Phe Leu Asp 
        195                 200                 205             


Ala His Cys Glu Cys Thr Leu Gly Trp Leu Glu Pro Leu Leu Ala Arg 
    210                 215                 220                 


Ile Lys Glu Asp Arg Lys Thr Val Val Cys Pro Ile Ile Asp Val Ile 
225                 230                 235                 240 


Ser Asp Asp Thr Phe Glu Tyr Met Ala Gly Ser Asp Met Thr Tyr Gly 
                245                 250                 255     


Gly Phe Asn Trp Lys Leu Asn Phe Arg Trp Tyr Pro Val Pro Gln Arg 
            260                 265                 270         


Glu Met Asp Arg Arg Lys Gly Asp Arg Thr Leu Pro Val Arg Thr Pro 
        275                 280                 285             


Thr Met Ala Gly Gly Leu Phe Ser Ile Asp Arg Asn Tyr Phe Glu Glu 
    290                 295                 300                 


Ile Gly Thr Tyr Asp Ala Gly Met Asp Ile Trp Gly Gly Glu Asn Leu 
305                 310                 315                 320 


Glu Met Ser Phe Arg Ile Trp Gln Cys Gly Gly Ser Leu Glu Ile Val 
                325                 330                 335     


Thr Cys Ser His Val Gly His Val Phe Arg Lys Ala Thr Pro Tyr Thr 
            340                 345                 350         


Phe Pro Gly Gly Thr Gly His Val Ile Asn Lys Asn Asn Arg Arg Leu 
        355                 360                 365             


Ala Glu Val Trp Met Asp Glu Phe Lys Asp Phe Phe Tyr Ile Ile Ser 
    370                 375                 380                 


Pro Gly Val Val Lys Val Asp Tyr Gly Asp Val Ser Val Arg Lys Thr 
385                 390                 395                 400 


Leu Arg Glu Asn Leu Lys Cys Lys Pro Phe Ser Trp Tyr Leu Glu Asn 
                405                 410                 415     


Ile Tyr Pro Asp Ser Gln Ile Pro Arg Arg Tyr Tyr Ser Leu Gly Glu 
            420                 425                 430         


Ile Arg Asn Val Glu Thr Asn Gln Cys Leu Asp Asn Met Gly Arg Lys 
        435                 440                 445             


Glu Asn Glu Lys Val Gly Ile Phe Asn Cys His Gly Met Gly Gly Asn 
    450                 455                 460                 


Gln Val Phe Ser Tyr Thr Ala Asp Lys Glu Ile Arg Thr Asp Asp Leu 
465                 470                 475                 480 


Cys Leu Asp Val Ser Arg Leu Asn Gly Pro Val Ile Met Leu Lys Cys 
                485                 490                 495     


His His Met Arg Gly Asn Gln Leu Trp Glu Tyr Asp Ala Glu Ser Cys 
            500                 505                 510         


Leu Ser Val Asn Lys Val Ala Asp Gly Ser Gln His Pro Thr Val Glu 
        515                 520                 525             


Thr Cys Asn Asp Ser Thr Leu Gln Lys Trp Leu Leu Arg Asn Tyr Thr 
    530                 535                 540                 


Arg Met Glu Ile Phe Arg Asn Ile Phe Gly Asn Ser Thr Asp Tyr Ile 
545                 550                 555                 560 


Leu 
    


<210>  4669
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  4669

Met Glu Leu Thr Gly Ile Asp Leu Leu Ser Gly Ile Ile Pro Glu Leu 
1               5                   10                  15      


Cys Gln Lys Tyr Pro Asp Leu Asn Phe Ile Ile Gly Gly Glu Gly Pro 
            20                  25                  30          


Lys Arg Ile Ile Leu Glu Glu Val Arg Glu Arg Tyr Gln Leu His Asp 
        35                  40                  45              


Arg Val Arg Leu Leu Gly Ala Leu Glu His Lys Asp Val Arg Asn Val 
    50                  55                  60                  


Leu Val Gln Gly His Ile Phe Leu Asn Thr Ser Leu Thr Glu Ala Phe 
65                  70                  75                  80  


Cys Met Ala Ile Val Glu Ala Ala Ser Cys Gly Leu Gln Val Val Ser 
                85                  90                  95      


Thr Arg Val Gly Gly Ile Pro Glu Val Leu Pro Glu Asn Leu Ile Ile 
            100                 105                 110         


Leu Cys Glu Pro Ser Val Lys Ser Leu Cys Glu Gly Leu Glu Lys Ala 
        115                 120                 125             


Ile Phe Gln Leu Lys Ser Gly Thr Leu Pro Ala Pro Glu Asn Ile His 
    130                 135                 140                 


Asn Ile Val Lys Thr Phe Tyr Thr Trp Arg Asn Val Ala Glu Arg Thr 
145                 150                 155                 160 


Glu Lys Val Tyr Asp Arg Val Ser Val Glu Ala Val Leu Pro Met Asp 
                165                 170                 175     


Lys Arg Leu Asp Arg Leu Ile Ser His Cys Gly Pro Val Thr Gly Tyr 
            180                 185                 190         


Ile Phe Ala Leu Leu Ala Val Phe Asn Phe Leu Phe Leu Ile Phe Leu 
        195                 200                 205             


Arg Trp Met Thr Pro Asp Ser Ile Ile Asp Val Ala Ile Asp Ala Thr 
    210                 215                 220                 


Gly Pro Arg Gly Ala Trp Thr Asn Asn Tyr Ser His Ser Lys Arg Gly 
225                 230                 235                 240 


Gly Glu Asn Asn Glu Ile Ser Glu Thr Arg 
                245                 250 


<210>  4670
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  4670

Met Arg Lys Phe Ala Tyr Cys Lys Val Val Leu Ala Thr Ser Leu Ile 
1               5                   10                  15      


Trp Val Leu Leu Asp Met Phe Leu Leu Leu Tyr Phe Ser Glu Cys Asn 
            20                  25                  30          


Lys Cys Asp Glu Lys Lys Glu Arg Gly Leu Pro Ala Gly Asp Val Leu 
        35                  40                  45              


Glu Pro Val Gln Lys Pro His Glu Gly Pro Gly Glu Met Gly Lys Pro 
    50                  55                  60                  


Val Val Ile Pro Lys Glu Asp Gln Glu Lys Met Lys Glu Met Phe Lys 
65                  70                  75                  80  


Ile Asn Gln Phe Asn Leu Met Ala Ser Glu Met Ile Ala Leu Asn Arg 
                85                  90                  95      


Ser Leu Pro Asp Val Arg Leu Glu Gly Cys Lys Thr Lys Val Tyr Pro 
            100                 105                 110         


Asp Asn Leu Pro Thr Thr Ser Val Val Ile Val Phe His Asn Glu Ala 
        115                 120                 125             


Trp Ser Thr Leu Leu Arg Thr Val His Ser Val Ile Asn Arg Ser Pro 
    130                 135                 140                 


Arg His Met Ile Glu Glu Ile Val Leu Val Asp Asp Ala Ser Glu Arg 
145                 150                 155                 160 


Asp Phe Leu Lys Arg Pro Leu Glu Ser Tyr Val Lys Lys Leu Lys Val 
                165                 170                 175     


Pro Val His Val Ile Arg Met Glu Gln Arg Ser Gly Leu Ile Arg Ala 
            180                 185                 190         


Arg Leu Lys Gly Ala Ala Val Ser Lys Gly Gln Val Ile Thr Phe Leu 
        195                 200                 205             


Asp Ala His Cys Glu Cys Thr Val Gly Trp Leu Glu Pro Leu Leu Ala 
    210                 215                 220                 


Arg Ile Lys His Asp Arg Arg Thr Val Val Cys Pro Ile Ile Asp Val 
225                 230                 235                 240 


Ile Ser Asp Asp Thr Phe Glu Tyr Met Ala Gly Ser Asp Met Thr Tyr 
                245                 250                 255     


Gly Gly Phe Asn Trp Lys Leu Asn Phe Arg Trp Tyr Pro Val Pro Gln 
            260                 265                 270         


Arg Glu Met Asp Arg Arg Lys Gly Asp Arg Thr Leu Pro Val Arg Thr 
        275                 280                 285             


Pro Thr Met Ala Gly Gly Leu Phe Ser Ile Asp Arg Asp Tyr Phe Gln 
    290                 295                 300                 


Glu Ile Gly Thr Tyr Asp Ala Gly Met Asp Ile Trp Gly Gly Glu Asn 
305                 310                 315                 320 


Leu Glu Ile Ser Phe Arg Ile Trp Gln Cys Gly Gly Thr Leu Glu Ile 
                325                 330                 335     


Val Thr Cys Ser His Val Gly His Val Phe Arg Lys Ala Thr Pro Tyr 
            340                 345                 350         


Thr Phe Pro Gly Gly Thr Gly Gln Ile Ile Asn Lys Asn Asn Arg Arg 
        355                 360                 365             


Leu Ala Glu Val Trp Met Asp Glu Phe Lys Asn Phe Phe Tyr Ile Ile 
    370                 375                 380                 


Ser Pro Gly Val Thr Lys Val Asp Tyr Gly Asp Ile Ser Ser Arg Val 
385                 390                 395                 400 


Gly Leu Arg His Lys Leu Gln Cys Lys Pro Phe Ser Trp Tyr Leu Glu 
                405                 410                 415     


Asn Ile Tyr Pro Asp Ser Gln Ile Pro Arg His Tyr Phe Ser Leu Gly 
            420                 425                 430         


Glu Ile Arg Asn Val Glu Thr Asn Gln Cys Leu Asp Asn Met Ala Arg 
        435                 440                 445             


Lys Glu Asn Glu Lys Val Gly Ile Phe Asn Cys His Gly Met Gly Gly 
    450                 455                 460                 


Asn Gln Val Phe Ser Tyr Thr Ala Asn Lys Glu Ile Arg Thr Asp Asp 
465                 470                 475                 480 


Leu Cys Leu Asp Val Ser Lys Leu Asn Gly Pro Val Thr Met Leu Lys 
                485                 490                 495     


Cys His His Leu Lys Gly Asn Gln Leu Trp Glu Tyr Asp Pro Val Lys 
            500                 505                 510         


Leu Thr Leu Gln His Val Asn Ser Asn Gln Cys Leu Asp Lys Ala Thr 
        515                 520                 525             


Glu Glu Asp Ser Gln Val Pro Ser Ile Arg Asp Cys Asn Gly Ser Arg 
    530                 535                 540                 


Ser Gln Gln Trp Leu Leu Arg Asn Val Thr Leu Pro Glu Ile Phe 
545                 550                 555                 


<210>  4671
<211>  1856
<212>  PRT
<213>  Homo sapiens

<400>  4671

Met Pro Tyr Ser Val Gly Phe Arg Glu Ala Asp Ala Ala Thr Ser Phe 
1               5                   10                  15      


Leu Arg Ala Ala Arg Ser Gly Asn Leu Asp Lys Ala Leu Asp His Leu 
            20                  25                  30          


Arg Asn Gly Val Asp Ile Asn Thr Cys Asn Gln Asn Gly Leu Asn Gly 
        35                  40                  45              


Leu His Leu Ala Ser Lys Glu Gly His Val Lys Met Val Val Glu Leu 
    50                  55                  60                  


Leu His Lys Glu Ile Ile Leu Glu Thr Thr Thr Lys Lys Gly Asn Thr 
65                  70                  75                  80  


Ala Leu His Ile Ala Ala Leu Ala Gly Gln Asp Glu Val Val Arg Glu 
                85                  90                  95      


Leu Val Asn Tyr Gly Ala Asn Val Asn Ala Gln Ser Gln Lys Gly Phe 
            100                 105                 110         


Thr Pro Leu Tyr Met Ala Ala Gln Glu Asn His Leu Glu Val Val Lys 
        115                 120                 125             


Phe Leu Leu Glu Asn Gly Ala Asn Gln Asn Val Ala Thr Glu Asp Gly 
    130                 135                 140                 


Phe Thr Pro Leu Ala Val Ala Leu Gln Gln Gly His Glu Asn Val Val 
145                 150                 155                 160 


Ala His Leu Ile Asn Tyr Gly Thr Lys Gly Lys Val Arg Leu Pro Ala 
                165                 170                 175     


Leu His Ile Ala Ala Arg Asn Asp Asp Thr Arg Thr Ala Ala Val Leu 
            180                 185                 190         


Leu Gln Asn Asp Pro Asn Pro Asp Val Leu Ser Lys Thr Gly Phe Thr 
        195                 200                 205             


Pro Leu His Ile Ala Ala His Tyr Glu Asn Leu Asn Val Ala Gln Leu 
    210                 215                 220                 


Leu Leu Asn Arg Gly Ala Ser Val Asn Phe Thr Pro Gln Asn Gly Ile 
225                 230                 235                 240 


Thr Pro Leu His Ile Ala Ser Arg Arg Gly Asn Val Ile Met Val Arg 
                245                 250                 255     


Leu Leu Leu Asp Arg Gly Ala Gln Ile Glu Thr Lys Thr Lys Asp Glu 
            260                 265                 270         


Leu Thr Pro Leu His Cys Ala Ala Arg Asn Gly His Val Arg Ile Ser 
        275                 280                 285             


Glu Ile Leu Leu Asp His Gly Ala Pro Ile Gln Ala Lys Thr Lys Asn 
    290                 295                 300                 


Gly Leu Ser Pro Ile His Met Ala Ala Gln Gly Asp His Leu Asp Cys 
305                 310                 315                 320 


Val Arg Leu Leu Leu Gln Tyr Asp Ala Glu Ile Asp Asp Ile Thr Leu 
                325                 330                 335     


Asp His Leu Thr Pro Leu His Val Ala Ala His Cys Gly His His Arg 
            340                 345                 350         


Val Ala Lys Val Leu Leu Asp Lys Gly Ala Lys Pro Asn Ser Arg Ala 
        355                 360                 365             


Leu Asn Gly Phe Thr Pro Leu His Ile Ala Cys Lys Lys Asn His Val 
    370                 375                 380                 


Arg Val Met Glu Leu Leu Leu Lys Thr Gly Ala Ser Ile Asp Ala Val 
385                 390                 395                 400 


Thr Glu Ser Gly Leu Thr Pro Leu His Val Ala Ser Phe Met Gly His 
                405                 410                 415     


Leu Pro Ile Val Lys Asn Leu Leu Gln Arg Gly Ala Ser Pro Asn Val 
            420                 425                 430         


Ser Asn Val Lys Val Glu Thr Pro Leu His Met Ala Ala Arg Ala Gly 
        435                 440                 445             


His Thr Glu Val Ala Lys Tyr Leu Leu Gln Asn Lys Ala Lys Val Asn 
    450                 455                 460                 


Ala Lys Ala Lys Asp Asp Gln Thr Pro Leu His Cys Ala Ala Arg Ile 
465                 470                 475                 480 


Gly His Thr Asn Met Val Lys Leu Leu Leu Glu Asn Asn Ala Asn Pro 
                485                 490                 495     


Asn Leu Ala Thr Thr Ala Gly His Thr Pro Leu His Ile Ala Ala Arg 
            500                 505                 510         


Glu Gly His Val Glu Thr Val Leu Ala Leu Leu Glu Lys Glu Ala Ser 
        515                 520                 525             


Gln Ala Cys Met Thr Lys Lys Gly Phe Thr Pro Leu His Val Ala Ala 
    530                 535                 540                 


Lys Tyr Gly Lys Val Arg Val Ala Glu Leu Leu Leu Glu Arg Asp Ala 
545                 550                 555                 560 


His Pro Asn Ala Ala Gly Lys Asn Gly Leu Thr Pro Leu His Val Ala 
                565                 570                 575     


Val His His Asn Asn Leu Asp Ile Val Lys Leu Leu Leu Pro Arg Gly 
            580                 585                 590         


Gly Ser Pro His Ser Pro Ala Trp Asn Gly Tyr Thr Pro Leu His Ile 
        595                 600                 605             


Ala Ala Lys Gln Asn Gln Val Glu Val Ala Arg Ser Leu Leu Gln Tyr 
    610                 615                 620                 


Gly Gly Ser Ala Asn Ala Glu Ser Val Gln Gly Val Thr Pro Leu His 
625                 630                 635                 640 


Leu Ala Ala Gln Glu Gly His Ala Glu Met Val Ala Leu Leu Leu Ser 
                645                 650                 655     


Lys Gln Ala Asn Gly Asn Leu Gly Asn Lys Ser Gly Leu Thr Pro Leu 
            660                 665                 670         


His Leu Val Ala Gln Glu Gly His Val Pro Val Ala Asp Val Leu Ile 
        675                 680                 685             


Lys His Gly Val Met Val Asp Ala Thr Thr Arg Met Gly Tyr Thr Pro 
    690                 695                 700                 


Leu His Val Ala Ser His Tyr Gly Asn Ile Lys Leu Val Lys Phe Leu 
705                 710                 715                 720 


Leu Gln His Gln Ala Asp Val Asn Ala Lys Thr Lys Leu Gly Tyr Ser 
                725                 730                 735     


Pro Leu His Gln Ala Ala Gln Gln Gly His Thr Asp Ile Val Thr Leu 
            740                 745                 750         


Leu Leu Lys Asn Gly Ala Ser Pro Asn Glu Val Ser Ser Asp Gly Thr 
        755                 760                 765             


Thr Pro Leu Ala Ile Ala Lys Arg Leu Gly Tyr Ile Ser Val Thr Asp 
    770                 775                 780                 


Val Leu Lys Val Val Thr Asp Glu Thr Ser Phe Val Leu Val Ser Asp 
785                 790                 795                 800 


Lys His Arg Met Ser Phe Pro Glu Thr Val Asp Glu Ile Leu Asp Val 
                805                 810                 815     


Ser Glu Asp Glu Gly Glu Glu Leu Ile Ser Phe Lys Ala Glu Arg Arg 
            820                 825                 830         


Asp Ser Arg Asp Val Asp Glu Glu Lys Glu Leu Leu Asp Phe Val Pro 
        835                 840                 845             


Lys Leu Asp Gln Val Val Glu Ser Pro Ala Ile Pro Arg Ile Pro Cys 
    850                 855                 860                 


Ala Met Pro Glu Thr Val Val Ile Arg Ser Glu Glu Gln Glu Gln Ala 
865                 870                 875                 880 


Ser Lys Glu Tyr Asp Glu Asp Ser Leu Ile Pro Ser Ser Pro Ala Thr 
                885                 890                 895     


Glu Thr Ser Asp Asn Ile Ser Pro Val Ala Ser Pro Val His Thr Gly 
            900                 905                 910         


Phe Leu Val Ser Phe Met Val Asp Ala Arg Gly Gly Ser Met Arg Gly 
        915                 920                 925             


Ser Arg His Asn Gly Leu Arg Val Val Ile Pro Pro Arg Thr Cys Ala 
    930                 935                 940                 


Ala Pro Thr Arg Ile Thr Cys Arg Leu Val Lys Pro Gln Lys Leu Ser 
945                 950                 955                 960 


Thr Pro Pro Pro Leu Ala Glu Glu Glu Gly Leu Ala Ser Arg Ile Ile 
                965                 970                 975     


Ala Leu Gly Pro Thr Gly Ala Gln Phe Leu Ser Pro Val Ile Val Glu 
            980                 985                 990         


Ile Pro His Phe Ala Ser His Gly  Arg Gly Asp Arg Glu  Leu Val Val 
        995                 1000                 1005             


Leu Arg  Ser Glu Asn Gly Ser  Val Trp Lys Glu His  Arg Ser Arg 
    1010                 1015                 1020             


Tyr Gly  Glu Ser Tyr Leu Asp  Gln Ile Leu Asn Gly  Met Asp Glu 
    1025                 1030                 1035             


Glu Leu  Gly Ser Leu Glu Glu  Leu Glu Lys Lys Arg  Val Cys Arg 
    1040                 1045                 1050             


Ile Ile  Thr Thr Asp Phe Pro  Leu Tyr Phe Val Ile  Met Ser Arg 
    1055                 1060                 1065             


Leu Cys  Gln Asp Tyr Asp Thr  Ile Gly Pro Glu Gly  Gly Ser Leu 
    1070                 1075                 1080             


Lys Ser  Lys Leu Val Pro Leu  Val Gln Ala Thr Phe  Pro Glu Asn 
    1085                 1090                 1095             


Ala Val  Thr Lys Arg Val Lys  Leu Ala Leu Gln Ala  Gln Pro Val 
    1100                 1105                 1110             


Pro Asp  Glu Leu Val Thr Lys  Leu Leu Gly Asn Gln  Ala Thr Phe 
    1115                 1120                 1125             


Ser Pro  Ile Val Thr Val Glu  Pro Arg Arg Arg Lys  Phe His Arg 
    1130                 1135                 1140             


Pro Ile  Gly Leu Arg Ile Pro  Leu Pro Pro Ser Trp  Thr Asp Asn 
    1145                 1150                 1155             


Pro Arg  Asp Ser Gly Glu Gly  Asp Thr Thr Ser Leu  Arg Leu Leu 
    1160                 1165                 1170             


Cys Ser  Val Ile Gly Gly Thr  Asp Gln Ala Gln Trp  Glu Asp Ile 
    1175                 1180                 1185             


Thr Gly  Thr Thr Lys Leu Val  Tyr Ala Asn Glu Cys  Ala Asn Phe 
    1190                 1195                 1200             


Thr Thr  Asn Val Ser Ala Arg  Phe Trp Leu Ser Asp  Cys Pro Arg 
    1205                 1210                 1215             


Thr Ala  Glu Ala Val Asn Phe  Ala Thr Leu Leu Tyr  Lys Glu Leu 
    1220                 1225                 1230             


Thr Ala  Val Pro Tyr Met Ala  Lys Phe Val Ile Phe  Ala Lys Met 
    1235                 1240                 1245             


Asn Asp  Pro Arg Glu Gly Arg  Leu Arg Cys Tyr Cys  Met Thr Asp 
    1250                 1255                 1260             


Asp Lys  Val Asp Lys Thr Leu  Glu Gln His Glu Asn  Phe Val Glu 
    1265                 1270                 1275             


Val Ala  Arg Ser Arg Asp Ile  Glu Val Leu Glu Gly  Met Ser Leu 
    1280                 1285                 1290             


Phe Ala  Glu Leu Ser Gly Asn  Leu Val Pro Val Lys  Lys Ala Ala 
    1295                 1300                 1305             


Gln Gln  Arg Ser Phe His Phe  Gln Ser Phe Arg Glu  Asn Arg Leu 
    1310                 1315                 1320             


Ala Met  Pro Val Lys Val Arg  Asp Ser Ser Arg Glu  Pro Gly Gly 
    1325                 1330                 1335             


Ser Leu  Ser Phe Leu Arg Lys  Ala Met Lys Tyr Glu  Asp Thr Gln 
    1340                 1345                 1350             


His Ile  Leu Cys His Leu Asn  Ile Thr Met Pro Pro  Cys Ala Lys 
    1355                 1360                 1365             


Gly Ser  Gly Ala Glu Asp Arg  Arg Arg Thr Pro Thr  Pro Leu Ala 
    1370                 1375                 1380             


Leu Arg  Tyr Ser Ile Leu Ser  Glu Ser Thr Pro Gly  Ser Leu Ser 
    1385                 1390                 1395             


Gly Thr  Glu Gln Ala Glu Met  Lys Met Ala Val Ile  Ser Glu His 
    1400                 1405                 1410             


Leu Gly  Leu Ser Trp Ala Glu  Leu Ala Arg Glu Leu  Gln Phe Ser 
    1415                 1420                 1425             


Val Glu  Asp Ile Asn Arg Ile  Arg Val Glu Asn Pro  Asn Ser Leu 
    1430                 1435                 1440             


Leu Glu  Gln Ser Val Ala Leu  Leu Asn Leu Trp Val  Ile Arg Glu 
    1445                 1450                 1455             


Gly Gln  Asn Ala Asn Met Glu  Asn Leu Tyr Thr Ala  Leu Gln Ser 
    1460                 1465                 1470             


Ile Asp  Arg Gly Glu Ile Val  Asn Met Leu Glu Gly  Ser Gly Arg 
    1475                 1480                 1485             


Gln Ser  Arg Asn Leu Lys Pro  Asp Arg Arg His Thr  Asp Arg Asp 
    1490                 1495                 1500             


Tyr Ser  Leu Ser Pro Ser Gln  Met Asn Gly Tyr Ser  Ser Leu Gln 
    1505                 1510                 1515             


Asp Glu  Leu Leu Ser Pro Ala  Ser Leu Gly Cys Ala  Leu Ser Ser 
    1520                 1525                 1530             


Pro Leu  Arg Ala Asp Gln Tyr  Trp Asn Glu Val Ala  Val Leu Asp 
    1535                 1540                 1545             


Ala Ile  Pro Leu Ala Ala Thr  Glu His Asp Thr Met  Leu Glu Met 
    1550                 1555                 1560             


Ser Asp  Met Gln Val Trp Ser  Ala Gly Leu Thr Pro  Ser Leu Val 
    1565                 1570                 1575             


Thr Ala  Glu Asp Ser Ser Leu  Glu Cys Ser Lys Ala  Glu Asp Ser 
    1580                 1585                 1590             


Asp Ala  Thr Gly His Glu Trp  Lys Leu Glu Gly Ala  Leu Ser Glu 
    1595                 1600                 1605             


Glu Pro  Arg Gly Pro Glu Leu  Gly Ser Leu Glu Leu  Val Glu Asp 
    1610                 1615                 1620             


Asp Thr  Val Asp Ser Asp Ala  Thr Asn Gly Leu Ile  Asp Leu Leu 
    1625                 1630                 1635             


Glu Gln  Glu Glu Gly Gln Arg  Ser Glu Glu Lys Leu  Pro Gly Ser 
    1640                 1645                 1650             


Lys Arg  Gln Asp Asp Ala Thr  Gly Ala Gly Gln Asp  Ser Glu Asn 
    1655                 1660                 1665             


Glu Val  Ser Leu Val Ser Gly  His Gln Arg Gly Gln  Ala Arg Ile 
    1670                 1675                 1680             


Thr His  Ser Pro Thr Val Ser  Gln Val Thr Glu Arg  Ser Gln Asp 
    1685                 1690                 1695             


Arg Leu  Gln Asp Trp Asp Ala  Asp Gly Ser Ile Val  Ser Tyr Leu 
    1700                 1705                 1710             


Gln Asp  Ala Ala Gln Gly Ser  Trp Gln Glu Glu Val  Thr Gln Gly 
    1715                 1720                 1725             


Pro His  Ser Phe Gln Gly Thr  Ser Thr Met Thr Glu  Gly Leu Glu 
    1730                 1735                 1740             


Pro Gly  Gly Ser Gln Glu Tyr  Glu Lys Val Leu Val  Ser Val Ser 
    1745                 1750                 1755             


Glu His  Thr Trp Thr Glu Gln  Pro Glu Ala Glu Ser  Ser Gln Ala 
    1760                 1765                 1770             


Asp Arg  Asp Arg Arg Gln Gln  Gly Gln Glu Glu Gln  Val Gln Glu 
    1775                 1780                 1785             


Ala Lys  Asn Thr Phe Thr Gln  Val Val Gln Gly Asn  Glu Phe Gln 
    1790                 1795                 1800             


Asn Ile  Pro Gly Glu Gln Val  Thr Glu Glu Gln Phe  Thr Asp Glu 
    1805                 1810                 1815             


Gln Gly  Asn Ile Val Thr Lys  Lys Ile Ile Arg Lys  Val Val Arg 
    1820                 1825                 1830             


Gln Ile  Asp Leu Ser Ser Ala  Asp Ala Ala Gln Glu  His Glu Glu 
    1835                 1840                 1845             


Asp His  Thr Ser Thr Pro Asn  Pro 
    1850                 1855     


<210>  4672
<211>  1881
<212>  PRT
<213>  Homo sapiens

<400>  4672

Met Pro Tyr Ser Val Gly Phe Arg Glu Ala Asp Ala Ala Thr Ser Phe 
1               5                   10                  15      


Leu Arg Ala Ala Arg Ser Gly Asn Leu Asp Lys Ala Leu Asp His Leu 
            20                  25                  30          


Arg Asn Gly Val Asp Ile Asn Thr Cys Asn Gln Asn Gly Leu Asn Gly 
        35                  40                  45              


Leu His Leu Ala Ser Lys Glu Gly His Val Lys Met Val Val Glu Leu 
    50                  55                  60                  


Leu His Lys Glu Ile Ile Leu Glu Thr Thr Thr Lys Lys Gly Asn Thr 
65                  70                  75                  80  


Ala Leu His Ile Ala Ala Leu Ala Gly Gln Asp Glu Val Val Arg Glu 
                85                  90                  95      


Leu Val Asn Tyr Gly Ala Asn Val Asn Ala Gln Ser Gln Lys Gly Phe 
            100                 105                 110         


Thr Pro Leu Tyr Met Ala Ala Gln Glu Asn His Leu Glu Val Val Lys 
        115                 120                 125             


Phe Leu Leu Glu Asn Gly Ala Asn Gln Asn Val Ala Thr Glu Asp Gly 
    130                 135                 140                 


Phe Thr Pro Leu Ala Val Ala Leu Gln Gln Gly His Glu Asn Val Val 
145                 150                 155                 160 


Ala His Leu Ile Asn Tyr Gly Thr Lys Gly Lys Val Arg Leu Pro Ala 
                165                 170                 175     


Leu His Ile Ala Ala Arg Asn Asp Asp Thr Arg Thr Ala Ala Val Leu 
            180                 185                 190         


Leu Gln Asn Asp Pro Asn Pro Asp Val Leu Ser Lys Thr Gly Phe Thr 
        195                 200                 205             


Pro Leu His Ile Ala Ala His Tyr Glu Asn Leu Asn Val Ala Gln Leu 
    210                 215                 220                 


Leu Leu Asn Arg Gly Ala Ser Val Asn Phe Thr Pro Gln Asn Gly Ile 
225                 230                 235                 240 


Thr Pro Leu His Ile Ala Ser Arg Arg Gly Asn Val Ile Met Val Arg 
                245                 250                 255     


Leu Leu Leu Asp Arg Gly Ala Gln Ile Glu Thr Lys Thr Lys Asp Glu 
            260                 265                 270         


Leu Thr Pro Leu His Cys Ala Ala Arg Asn Gly His Val Arg Ile Ser 
        275                 280                 285             


Glu Ile Leu Leu Asp His Gly Ala Pro Ile Gln Ala Lys Thr Lys Asn 
    290                 295                 300                 


Gly Leu Ser Pro Ile His Met Ala Ala Gln Gly Asp His Leu Asp Cys 
305                 310                 315                 320 


Val Arg Leu Leu Leu Gln Tyr Asp Ala Glu Ile Asp Asp Ile Thr Leu 
                325                 330                 335     


Asp His Leu Thr Pro Leu His Val Ala Ala His Cys Gly His His Arg 
            340                 345                 350         


Val Ala Lys Val Leu Leu Asp Lys Gly Ala Lys Pro Asn Ser Arg Ala 
        355                 360                 365             


Leu Asn Gly Phe Thr Pro Leu His Ile Ala Cys Lys Lys Asn His Val 
    370                 375                 380                 


Arg Val Met Glu Leu Leu Leu Lys Thr Gly Ala Ser Ile Asp Ala Val 
385                 390                 395                 400 


Thr Glu Ser Gly Leu Thr Pro Leu His Val Ala Ser Phe Met Gly His 
                405                 410                 415     


Leu Pro Ile Val Lys Asn Leu Leu Gln Arg Gly Ala Ser Pro Asn Val 
            420                 425                 430         


Ser Asn Val Lys Val Glu Thr Pro Leu His Met Ala Ala Arg Ala Gly 
        435                 440                 445             


His Thr Glu Val Ala Lys Tyr Leu Leu Gln Asn Lys Ala Lys Val Asn 
    450                 455                 460                 


Ala Lys Ala Lys Asp Asp Gln Thr Pro Leu His Cys Ala Ala Arg Ile 
465                 470                 475                 480 


Gly His Thr Asn Met Val Lys Leu Leu Leu Glu Asn Asn Ala Asn Pro 
                485                 490                 495     


Asn Leu Ala Thr Thr Ala Gly His Thr Pro Leu His Ile Ala Ala Arg 
            500                 505                 510         


Glu Gly His Val Glu Thr Val Leu Ala Leu Leu Glu Lys Glu Ala Ser 
        515                 520                 525             


Gln Ala Cys Met Thr Lys Lys Gly Phe Thr Pro Leu His Val Ala Ala 
    530                 535                 540                 


Lys Tyr Gly Lys Val Arg Val Ala Glu Leu Leu Leu Glu Arg Asp Ala 
545                 550                 555                 560 


His Pro Asn Ala Ala Gly Lys Asn Gly Leu Thr Pro Leu His Val Ala 
                565                 570                 575     


Val His His Asn Asn Leu Asp Ile Val Lys Leu Leu Leu Pro Arg Gly 
            580                 585                 590         


Gly Ser Pro His Ser Pro Ala Trp Asn Gly Tyr Thr Pro Leu His Ile 
        595                 600                 605             


Ala Ala Lys Gln Asn Gln Val Glu Val Ala Arg Ser Leu Leu Gln Tyr 
    610                 615                 620                 


Gly Gly Ser Ala Asn Ala Glu Ser Val Gln Gly Val Thr Pro Leu His 
625                 630                 635                 640 


Leu Ala Ala Gln Glu Gly His Ala Glu Met Val Ala Leu Leu Leu Ser 
                645                 650                 655     


Lys Gln Ala Asn Gly Asn Leu Gly Asn Lys Ser Gly Leu Thr Pro Leu 
            660                 665                 670         


His Leu Val Ala Gln Glu Gly His Val Pro Val Ala Asp Val Leu Ile 
        675                 680                 685             


Lys His Gly Val Met Val Asp Ala Thr Thr Arg Met Gly Tyr Thr Pro 
    690                 695                 700                 


Leu His Val Ala Ser His Tyr Gly Asn Ile Lys Leu Val Lys Phe Leu 
705                 710                 715                 720 


Leu Gln His Gln Ala Asp Val Asn Ala Lys Thr Lys Leu Gly Tyr Ser 
                725                 730                 735     


Pro Leu His Gln Ala Ala Gln Gln Gly His Thr Asp Ile Val Thr Leu 
            740                 745                 750         


Leu Leu Lys Asn Gly Ala Ser Pro Asn Glu Val Ser Ser Asp Gly Thr 
        755                 760                 765             


Thr Pro Leu Ala Ile Ala Lys Arg Leu Gly Tyr Ile Ser Val Thr Asp 
    770                 775                 780                 


Val Leu Lys Val Val Thr Asp Glu Thr Ser Phe Val Leu Val Ser Asp 
785                 790                 795                 800 


Lys His Arg Met Ser Phe Pro Glu Thr Val Asp Glu Ile Leu Asp Val 
                805                 810                 815     


Ser Glu Asp Glu Gly Glu Glu Leu Ile Ser Phe Lys Ala Glu Arg Arg 
            820                 825                 830         


Asp Ser Arg Asp Val Asp Glu Glu Lys Glu Leu Leu Asp Phe Val Pro 
        835                 840                 845             


Lys Leu Asp Gln Val Val Glu Ser Pro Ala Ile Pro Arg Ile Pro Cys 
    850                 855                 860                 


Ala Met Pro Glu Thr Val Val Ile Arg Ser Glu Glu Gln Glu Gln Ala 
865                 870                 875                 880 


Ser Lys Glu Tyr Asp Glu Asp Ser Leu Ile Pro Ser Ser Pro Ala Thr 
                885                 890                 895     


Glu Thr Ser Asp Asn Ile Ser Pro Val Ala Ser Pro Val His Thr Gly 
            900                 905                 910         


Phe Leu Val Ser Phe Met Val Asp Ala Arg Gly Gly Ser Met Arg Gly 
        915                 920                 925             


Ser Arg His Asn Gly Leu Arg Val Val Ile Pro Pro Arg Thr Cys Ala 
    930                 935                 940                 


Ala Pro Thr Arg Ile Thr Cys Arg Leu Val Lys Pro Gln Lys Leu Ser 
945                 950                 955                 960 


Thr Pro Pro Pro Leu Ala Glu Glu Glu Gly Leu Ala Ser Arg Ile Ile 
                965                 970                 975     


Ala Leu Gly Pro Thr Gly Ala Gln Phe Leu Ser Pro Val Ile Val Glu 
            980                 985                 990         


Ile Pro His Phe Ala Ser His Gly  Arg Gly Asp Arg Glu  Leu Val Val 
        995                 1000                 1005             


Leu Arg  Ser Glu Asn Gly Ser  Val Trp Lys Glu His  Arg Ser Arg 
    1010                 1015                 1020             


Tyr Gly  Glu Ser Tyr Leu Asp  Gln Ile Leu Asn Gly  Met Asp Glu 
    1025                 1030                 1035             


Glu Leu  Gly Ser Leu Glu Glu  Leu Glu Lys Lys Arg  Val Cys Arg 
    1040                 1045                 1050             


Ile Ile  Thr Thr Asp Phe Pro  Leu Tyr Phe Val Ile  Met Ser Arg 
    1055                 1060                 1065             


Leu Cys  Gln Asp Tyr Asp Thr  Ile Gly Pro Glu Gly  Gly Ser Leu 
    1070                 1075                 1080             


Lys Ser  Lys Leu Val Pro Leu  Val Gln Ala Thr Phe  Pro Glu Asn 
    1085                 1090                 1095             


Ala Val  Thr Lys Arg Val Lys  Leu Ala Leu Gln Ala  Gln Pro Val 
    1100                 1105                 1110             


Pro Asp  Glu Leu Val Thr Lys  Leu Leu Gly Asn Gln  Ala Thr Phe 
    1115                 1120                 1125             


Ser Pro  Ile Val Thr Val Glu  Pro Arg Arg Arg Lys  Phe His Arg 
    1130                 1135                 1140             


Pro Ile  Gly Leu Arg Ile Pro  Leu Pro Pro Ser Trp  Thr Asp Asn 
    1145                 1150                 1155             


Pro Arg  Asp Ser Gly Glu Gly  Asp Thr Thr Ser Leu  Arg Leu Leu 
    1160                 1165                 1170             


Cys Ser  Val Ile Gly Gly Thr  Asp Gln Ala Gln Trp  Glu Asp Ile 
    1175                 1180                 1185             


Thr Gly  Thr Thr Lys Leu Val  Tyr Ala Asn Glu Cys  Ala Asn Phe 
    1190                 1195                 1200             


Thr Thr  Asn Val Ser Ala Arg  Phe Trp Leu Ser Asp  Cys Pro Arg 
    1205                 1210                 1215             


Thr Ala  Glu Ala Val Asn Phe  Ala Thr Leu Leu Tyr  Lys Glu Leu 
    1220                 1225                 1230             


Thr Ala  Val Pro Tyr Met Ala  Lys Phe Val Ile Phe  Ala Lys Met 
    1235                 1240                 1245             


Asn Asp  Pro Arg Glu Gly Arg  Leu Arg Cys Tyr Cys  Met Thr Asp 
    1250                 1255                 1260             


Asp Lys  Val Asp Lys Thr Leu  Glu Gln His Glu Asn  Phe Val Glu 
    1265                 1270                 1275             


Val Ala  Arg Ser Arg Asp Ile  Glu Val Leu Glu Gly  Met Ser Leu 
    1280                 1285                 1290             


Phe Ala  Glu Leu Ser Gly Asn  Leu Val Pro Val Lys  Lys Ala Ala 
    1295                 1300                 1305             


Gln Gln  Arg Ser Phe His Phe  Gln Ser Phe Arg Glu  Asn Arg Leu 
    1310                 1315                 1320             


Ala Met  Pro Val Lys Val Arg  Asp Ser Ser Arg Glu  Pro Gly Gly 
    1325                 1330                 1335             


Ser Leu  Ser Phe Leu Arg Lys  Ala Met Lys Tyr Glu  Asp Thr Gln 
    1340                 1345                 1350             


His Ile  Leu Cys His Leu Asn  Ile Thr Met Pro Pro  Cys Ala Lys 
    1355                 1360                 1365             


Gly Ser  Gly Ala Glu Asp Arg  Arg Arg Thr Pro Thr  Pro Leu Ala 
    1370                 1375                 1380             


Leu Arg  Tyr Ser Ile Leu Ser  Glu Ser Thr Pro Gly  Ser Leu Ser 
    1385                 1390                 1395             


Gly Thr  Glu Gln Ala Glu Met  Lys Met Ala Val Ile  Ser Glu His 
    1400                 1405                 1410             


Leu Gly  Leu Ser Trp Ala Glu  Leu Ala Arg Glu Leu  Gln Phe Ser 
    1415                 1420                 1425             


Val Glu  Asp Ile Asn Arg Ile  Arg Val Glu Asn Pro  Asn Ser Leu 
    1430                 1435                 1440             


Leu Glu  Gln Ser Val Ala Leu  Leu Asn Leu Trp Val  Ile Arg Glu 
    1445                 1450                 1455             


Gly Gln  Asn Ala Asn Met Glu  Asn Leu Tyr Thr Ala  Leu Gln Ser 
    1460                 1465                 1470             


Ile Asp  Arg Gly Glu Ile Val  Asn Met Leu Glu Gly  Ser Gly Arg 
    1475                 1480                 1485             


Gln Ser  Arg Asn Leu Lys Pro  Asp Arg Arg His Thr  Asp Arg Asp 
    1490                 1495                 1500             


Tyr Ser  Leu Ser Pro Ser Gln  Met Asn Gly Tyr Ser  Ser Leu Gln 
    1505                 1510                 1515             


Asp Glu  Leu Leu Ser Pro Ala  Ser Leu Gly Cys Ala  Leu Ser Ser 
    1520                 1525                 1530             


Pro Leu  Arg Ala Asp Gln Tyr  Trp Asn Glu Val Ala  Val Leu Asp 
    1535                 1540                 1545             


Ala Ile  Pro Leu Ala Ala Thr  Glu His Asp Thr Met  Leu Glu Met 
    1550                 1555                 1560             


Ser Asp  Met Gln Val Trp Ser  Ala Gly Leu Thr Pro  Ser Leu Val 
    1565                 1570                 1575             


Thr Ala  Glu Asp Ser Ser Leu  Glu Cys Ser Lys Ala  Glu Asp Ser 
    1580                 1585                 1590             


Asp Ala  Thr Gly His Glu Trp  Lys Leu Glu Gly Ala  Leu Ser Glu 
    1595                 1600                 1605             


Glu Pro  Arg Gly Pro Glu Leu  Gly Ser Leu Glu Leu  Val Glu Asp 
    1610                 1615                 1620             


Asp Thr  Val Asp Ser Asp Ala  Thr Asn Gly Leu Ile  Asp Leu Leu 
    1625                 1630                 1635             


Glu Gln  Glu Glu Gly Gln Arg  Ser Glu Glu Lys Leu  Pro Gly Ser 
    1640                 1645                 1650             


Lys Arg  Gln Asp Asp Ala Thr  Gly Ala Gly Gln Asp  Ser Glu Asn 
    1655                 1660                 1665             


Glu Val  Ser Leu Val Ser Gly  His Gln Arg Gly Gln  Ala Arg Ile 
    1670                 1675                 1680             


Thr His  Ser Pro Thr Val Ser  Gln Val Thr Glu Arg  Ser Gln Asp 
    1685                 1690                 1695             


Arg Leu  Gln Asp Trp Asp Ala  Asp Gly Ser Ile Val  Ser Tyr Leu 
    1700                 1705                 1710             


Gln Asp  Ala Ala Gln Gly Ser  Trp Gln Glu Glu Val  Thr Gln Gly 
    1715                 1720                 1725             


Pro His  Ser Phe Gln Gly Thr  Ser Thr Met Thr Glu  Gly Leu Glu 
    1730                 1735                 1740             


Pro Gly  Gly Ser Gln Glu Tyr  Glu Lys Val Leu Val  Ser Val Ser 
    1745                 1750                 1755             


Glu His  Thr Trp Thr Glu Gln  Pro Glu Ala Glu Ser  Ser Gln Ala 
    1760                 1765                 1770             


Asp Arg  Asp Arg Arg Gln Gln  Gly Gln Glu Glu Gln  Val Gln Glu 
    1775                 1780                 1785             


Ala Lys  Asn Thr Phe Thr Gln  Val Val Gln Gly Asn  Glu Phe Gln 
    1790                 1795                 1800             


Asn Ile  Pro Gly Glu Gln Val  Thr Glu Glu Gln Phe  Thr Asp Glu 
    1805                 1810                 1815             


Gln Gly  Asn Ile Val Thr Lys  Lys Ile Ile Arg Lys  Val Val Arg 
    1820                 1825                 1830             


Gln Ile  Asp Leu Ser Ser Ala  Asp Ala Ala Gln Glu  His Glu Glu 
    1835                 1840                 1845             


Val Thr  Val Glu Gly Pro Leu  Glu Asp Pro Ser Glu  Leu Glu Val 
    1850                 1855                 1860             


Asp Ile  Asp Tyr Phe Met Lys  His Ser Lys Asp His  Thr Ser Thr 
    1865                 1870                 1875             


Pro Asn  Pro 
    1880     


<210>  4673
<211>  1719
<212>  PRT
<213>  Homo sapiens

<400>  4673

Met Pro Tyr Ser Val Gly Phe Arg Glu Ala Asp Ala Ala Thr Ser Phe 
1               5                   10                  15      


Leu Arg Ala Ala Arg Ser Gly Asn Leu Asp Lys Ala Leu Asp His Leu 
            20                  25                  30          


Arg Asn Gly Val Asp Ile Asn Thr Cys Asn Gln Asn Gly Leu Asn Gly 
        35                  40                  45              


Leu His Leu Ala Ser Lys Glu Gly His Val Lys Met Val Val Glu Leu 
    50                  55                  60                  


Leu His Lys Glu Ile Ile Leu Glu Thr Thr Thr Lys Lys Gly Asn Thr 
65                  70                  75                  80  


Ala Leu His Ile Ala Ala Leu Ala Gly Gln Asp Glu Val Val Arg Glu 
                85                  90                  95      


Leu Val Asn Tyr Gly Ala Asn Val Asn Ala Gln Ser Gln Lys Gly Phe 
            100                 105                 110         


Thr Pro Leu Tyr Met Ala Ala Gln Glu Asn His Leu Glu Val Val Lys 
        115                 120                 125             


Phe Leu Leu Glu Asn Gly Ala Asn Gln Asn Val Ala Thr Glu Asp Gly 
    130                 135                 140                 


Phe Thr Pro Leu Ala Val Ala Leu Gln Gln Gly His Glu Asn Val Val 
145                 150                 155                 160 


Ala His Leu Ile Asn Tyr Gly Thr Lys Gly Lys Val Arg Leu Pro Ala 
                165                 170                 175     


Leu His Ile Ala Ala Arg Asn Asp Asp Thr Arg Thr Ala Ala Val Leu 
            180                 185                 190         


Leu Gln Asn Asp Pro Asn Pro Asp Val Leu Ser Lys Thr Gly Phe Thr 
        195                 200                 205             


Pro Leu His Ile Ala Ala His Tyr Glu Asn Leu Asn Val Ala Gln Leu 
    210                 215                 220                 


Leu Leu Asn Arg Gly Ala Ser Val Asn Phe Thr Pro Gln Asn Gly Ile 
225                 230                 235                 240 


Thr Pro Leu His Ile Ala Ser Arg Arg Gly Asn Val Ile Met Val Arg 
                245                 250                 255     


Leu Leu Leu Asp Arg Gly Ala Gln Ile Glu Thr Lys Thr Lys Asp Glu 
            260                 265                 270         


Leu Thr Pro Leu His Cys Ala Ala Arg Asn Gly His Val Arg Ile Ser 
        275                 280                 285             


Glu Ile Leu Leu Asp His Gly Ala Pro Ile Gln Ala Lys Thr Lys Asn 
    290                 295                 300                 


Gly Leu Ser Pro Ile His Met Ala Ala Gln Gly Asp His Leu Asp Cys 
305                 310                 315                 320 


Val Arg Leu Leu Leu Gln Tyr Asp Ala Glu Ile Asp Asp Ile Thr Leu 
                325                 330                 335     


Asp His Leu Thr Pro Leu His Val Ala Ala His Cys Gly His His Arg 
            340                 345                 350         


Val Ala Lys Val Leu Leu Asp Lys Gly Ala Lys Pro Asn Ser Arg Ala 
        355                 360                 365             


Leu Asn Gly Phe Thr Pro Leu His Ile Ala Cys Lys Lys Asn His Val 
    370                 375                 380                 


Arg Val Met Glu Leu Leu Leu Lys Thr Gly Ala Ser Ile Asp Ala Val 
385                 390                 395                 400 


Thr Glu Ser Gly Leu Thr Pro Leu His Val Ala Ser Phe Met Gly His 
                405                 410                 415     


Leu Pro Ile Val Lys Asn Leu Leu Gln Arg Gly Ala Ser Pro Asn Val 
            420                 425                 430         


Ser Asn Val Lys Val Glu Thr Pro Leu His Met Ala Ala Arg Ala Gly 
        435                 440                 445             


His Thr Glu Val Ala Lys Tyr Leu Leu Gln Asn Lys Ala Lys Val Asn 
    450                 455                 460                 


Ala Lys Ala Lys Asp Asp Gln Thr Pro Leu His Cys Ala Ala Arg Ile 
465                 470                 475                 480 


Gly His Thr Asn Met Val Lys Leu Leu Leu Glu Asn Asn Ala Asn Pro 
                485                 490                 495     


Asn Leu Ala Thr Thr Ala Gly His Thr Pro Leu His Ile Ala Ala Arg 
            500                 505                 510         


Glu Gly His Val Glu Thr Val Leu Ala Leu Leu Glu Lys Glu Ala Ser 
        515                 520                 525             


Gln Ala Cys Met Thr Lys Lys Gly Phe Thr Pro Leu His Val Ala Ala 
    530                 535                 540                 


Lys Tyr Gly Lys Val Arg Val Ala Glu Leu Leu Leu Glu Arg Asp Ala 
545                 550                 555                 560 


His Pro Asn Ala Ala Gly Lys Asn Gly Leu Thr Pro Leu His Val Ala 
                565                 570                 575     


Val His His Asn Asn Leu Asp Ile Val Lys Leu Leu Leu Pro Arg Gly 
            580                 585                 590         


Gly Ser Pro His Ser Pro Ala Trp Asn Gly Tyr Thr Pro Leu His Ile 
        595                 600                 605             


Ala Ala Lys Gln Asn Gln Val Glu Val Ala Arg Ser Leu Leu Gln Tyr 
    610                 615                 620                 


Gly Gly Ser Ala Asn Ala Glu Ser Val Gln Gly Val Thr Pro Leu His 
625                 630                 635                 640 


Leu Ala Ala Gln Glu Gly His Ala Glu Met Val Ala Leu Leu Leu Ser 
                645                 650                 655     


Lys Gln Ala Asn Gly Asn Leu Gly Asn Lys Ser Gly Leu Thr Pro Leu 
            660                 665                 670         


His Leu Val Ala Gln Glu Gly His Val Pro Val Ala Asp Val Leu Ile 
        675                 680                 685             


Lys His Gly Val Met Val Asp Ala Thr Thr Arg Met Gly Tyr Thr Pro 
    690                 695                 700                 


Leu His Val Ala Ser His Tyr Gly Asn Ile Lys Leu Val Lys Phe Leu 
705                 710                 715                 720 


Leu Gln His Gln Ala Asp Val Asn Ala Lys Thr Lys Leu Gly Tyr Ser 
                725                 730                 735     


Pro Leu His Gln Ala Ala Gln Gln Gly His Thr Asp Ile Val Thr Leu 
            740                 745                 750         


Leu Leu Lys Asn Gly Ala Ser Pro Asn Glu Val Ser Ser Asp Gly Thr 
        755                 760                 765             


Thr Pro Leu Ala Ile Ala Lys Arg Leu Gly Tyr Ile Ser Val Thr Asp 
    770                 775                 780                 


Val Leu Lys Val Val Thr Asp Glu Thr Ser Phe Val Leu Val Ser Asp 
785                 790                 795                 800 


Lys His Arg Met Ser Phe Pro Glu Thr Val Asp Glu Ile Leu Asp Val 
                805                 810                 815     


Ser Glu Asp Glu Gly Glu Glu Leu Ile Ser Phe Lys Ala Glu Arg Arg 
            820                 825                 830         


Asp Ser Arg Asp Val Asp Glu Glu Lys Glu Leu Leu Asp Phe Val Pro 
        835                 840                 845             


Lys Leu Asp Gln Val Val Glu Ser Pro Ala Ile Pro Arg Ile Pro Cys 
    850                 855                 860                 


Ala Met Pro Glu Thr Val Val Ile Arg Ser Glu Glu Gln Glu Gln Ala 
865                 870                 875                 880 


Ser Lys Glu Tyr Asp Glu Asp Ser Leu Ile Pro Ser Ser Pro Ala Thr 
                885                 890                 895     


Glu Thr Ser Asp Asn Ile Ser Pro Val Ala Ser Pro Val His Thr Gly 
            900                 905                 910         


Phe Leu Val Ser Phe Met Val Asp Ala Arg Gly Gly Ser Met Arg Gly 
        915                 920                 925             


Ser Arg His Asn Gly Leu Arg Val Val Ile Pro Pro Arg Thr Cys Ala 
    930                 935                 940                 


Ala Pro Thr Arg Ile Thr Cys Arg Leu Val Lys Pro Gln Lys Leu Ser 
945                 950                 955                 960 


Thr Pro Pro Pro Leu Ala Glu Glu Glu Gly Leu Ala Ser Arg Ile Ile 
                965                 970                 975     


Ala Leu Gly Pro Thr Gly Ala Gln Phe Leu Ser Pro Val Ile Val Glu 
            980                 985                 990         


Ile Pro His Phe Ala Ser His Gly  Arg Gly Asp Arg Glu  Leu Val Val 
        995                 1000                 1005             


Leu Arg  Ser Glu Asn Gly Ser  Val Trp Lys Glu His  Arg Ser Arg 
    1010                 1015                 1020             


Tyr Gly  Glu Ser Tyr Leu Asp  Gln Ile Leu Asn Gly  Met Asp Glu 
    1025                 1030                 1035             


Glu Leu  Gly Ser Leu Glu Glu  Leu Glu Lys Lys Arg  Val Cys Arg 
    1040                 1045                 1050             


Ile Ile  Thr Thr Asp Phe Pro  Leu Tyr Phe Val Ile  Met Ser Arg 
    1055                 1060                 1065             


Leu Cys  Gln Asp Tyr Asp Thr  Ile Gly Pro Glu Gly  Gly Ser Leu 
    1070                 1075                 1080             


Lys Ser  Lys Leu Val Pro Leu  Val Gln Ala Thr Phe  Pro Glu Asn 
    1085                 1090                 1095             


Ala Val  Thr Lys Arg Val Lys  Leu Ala Leu Gln Ala  Gln Pro Val 
    1100                 1105                 1110             


Pro Asp  Glu Leu Val Thr Lys  Leu Leu Gly Asn Gln  Ala Thr Phe 
    1115                 1120                 1125             


Ser Pro  Ile Val Thr Val Glu  Pro Arg Arg Arg Lys  Phe His Arg 
    1130                 1135                 1140             


Pro Ile  Gly Leu Arg Ile Pro  Leu Pro Pro Ser Trp  Thr Asp Asn 
    1145                 1150                 1155             


Pro Arg  Asp Ser Gly Glu Gly  Asp Thr Thr Ser Leu  Arg Leu Leu 
    1160                 1165                 1170             


Cys Ser  Val Ile Gly Gly Thr  Asp Gln Ala Gln Trp  Glu Asp Ile 
    1175                 1180                 1185             


Thr Gly  Thr Thr Lys Leu Val  Tyr Ala Asn Glu Cys  Ala Asn Phe 
    1190                 1195                 1200             


Thr Thr  Asn Val Ser Ala Arg  Phe Trp Leu Ser Asp  Cys Pro Arg 
    1205                 1210                 1215             


Thr Ala  Glu Ala Val Asn Phe  Ala Thr Leu Leu Tyr  Lys Glu Leu 
    1220                 1225                 1230             


Thr Ala  Val Pro Tyr Met Ala  Lys Phe Val Ile Phe  Ala Lys Met 
    1235                 1240                 1245             


Asn Asp  Pro Arg Glu Gly Arg  Leu Arg Cys Tyr Cys  Met Thr Asp 
    1250                 1255                 1260             


Asp Lys  Val Asp Lys Thr Leu  Glu Gln His Glu Asn  Phe Val Glu 
    1265                 1270                 1275             


Val Ala  Arg Ser Arg Asp Ile  Glu Val Leu Glu Gly  Met Ser Leu 
    1280                 1285                 1290             


Phe Ala  Glu Leu Ser Gly Asn  Leu Val Pro Val Lys  Lys Ala Ala 
    1295                 1300                 1305             


Gln Gln  Arg Ser Phe His Phe  Gln Ser Phe Arg Glu  Asn Arg Leu 
    1310                 1315                 1320             


Ala Met  Pro Val Lys Val Arg  Asp Ser Ser Arg Glu  Pro Gly Gly 
    1325                 1330                 1335             


Ser Leu  Ser Phe Leu Arg Lys  Ala Met Lys Tyr Glu  Asp Thr Gln 
    1340                 1345                 1350             


His Ile  Leu Cys His Leu Asn  Ile Thr Met Pro Pro  Cys Ala Lys 
    1355                 1360                 1365             


Gly Ser  Gly Ala Glu Asp Arg  Arg Arg Thr Pro Thr  Pro Leu Ala 
    1370                 1375                 1380             


Leu Arg  Tyr Ser Ile Leu Ser  Glu Ser Thr Pro Gly  Ser Leu Ser 
    1385                 1390                 1395             


Gly Thr  Glu Gln Ala Glu Met  Lys Met Ala Val Ile  Ser Glu His 
    1400                 1405                 1410             


Leu Gly  Leu Ser Trp Ala Glu  Leu Ala Arg Glu Leu  Gln Phe Ser 
    1415                 1420                 1425             


Val Glu  Asp Ile Asn Arg Ile  Arg Val Glu Asn Pro  Asn Ser Leu 
    1430                 1435                 1440             


Leu Glu  Gln Ser Val Ala Leu  Leu Asn Leu Trp Val  Ile Arg Glu 
    1445                 1450                 1455             


Gly Gln  Asn Ala Asn Met Glu  Asn Leu Tyr Thr Ala  Leu Gln Ser 
    1460                 1465                 1470             


Ile Asp  Arg Gly Glu Ile Val  Asn Met Leu Glu Gly  Ser Gly Arg 
    1475                 1480                 1485             


Gln Ser  Arg Asn Leu Lys Pro  Asp Arg Arg His Thr  Asp Arg Asp 
    1490                 1495                 1500             


Tyr Ser  Leu Ser Pro Ser Gln  Met Asn Gly His Gln  Arg Gly Gln 
    1505                 1510                 1515             


Ala Arg  Ile Thr His Ser Pro  Thr Val Ser Gln Val  Thr Glu Arg 
    1520                 1525                 1530             


Ser Gln  Asp Arg Leu Gln Asp  Trp Asp Ala Asp Gly  Ser Ile Val 
    1535                 1540                 1545             


Ser Tyr  Leu Gln Asp Ala Ala  Gln Gly Ser Trp Gln  Glu Glu Val 
    1550                 1555                 1560             


Thr Gln  Gly Pro His Ser Phe  Gln Gly Thr Ser Thr  Met Thr Glu 
    1565                 1570                 1575             


Gly Leu  Glu Pro Gly Gly Ser  Gln Glu Tyr Glu Lys  Val Leu Val 
    1580                 1585                 1590             


Ser Val  Ser Glu His Thr Trp  Thr Glu Gln Pro Glu  Ala Glu Ser 
    1595                 1600                 1605             


Ser Gln  Ala Asp Arg Asp Arg  Arg Gln Gln Gly Gln  Glu Glu Gln 
    1610                 1615                 1620             


Val Gln  Glu Ala Lys Asn Thr  Phe Thr Gln Val Val  Gln Gly Asn 
    1625                 1630                 1635             


Glu Phe  Gln Asn Ile Pro Gly  Glu Gln Val Thr Glu  Glu Gln Phe 
    1640                 1645                 1650             


Thr Asp  Glu Gln Gly Asn Ile  Val Thr Lys Lys Ile  Ile Arg Lys 
    1655                 1660                 1665             


Val Val  Arg Gln Ile Asp Leu  Ser Ser Ala Asp Ala  Ala Gln Glu 
    1670                 1675                 1680             


His Glu  Glu Val Thr Val Glu  Gly Pro Leu Glu Asp  Pro Ser Glu 
    1685                 1690                 1695             


Leu Glu  Val Asp Ile Asp Tyr  Phe Met Lys His Ser  Lys Asp His 
    1700                 1705                 1710             


Thr Ser  Thr Pro Asn Pro 
    1715                 


<210>  4674
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  4674

Met Trp Thr Phe Val Thr Gln Leu Leu Val Thr Leu Val Leu Leu Ser 
1               5                   10                  15      


Phe Phe Leu Val Ser Cys Gln Asn Val Met His Ile Val Arg Gly Ser 
            20                  25                  30          


Leu Cys Phe Val Leu Lys His Ile His Gln Glu Leu Asp Lys Glu Leu 
        35                  40                  45              


Gly Glu Ser Glu Gly Leu Ser Asp Asp Glu Glu Thr Ile Ser Thr Arg 
    50                  55                  60                  


Val Val Arg Arg Arg Val Phe Leu Lys Gly Asn Glu Phe Gln Asn Ile 
65                  70                  75                  80  


Pro Gly Glu Gln Val Thr Glu Glu Gln Phe Thr Asp Glu Gln Gly Asn 
                85                  90                  95      


Ile Val Thr Lys Lys Ile Ile Arg Lys Val Val Arg Gln Ile Asp Leu 
            100                 105                 110         


Ser Ser Ala Asp Ala Ala Gln Glu His Glu Glu Val Glu Leu Arg Gly 
        115                 120                 125             


Ser Gly Leu Gln Pro Asp Leu Ile Glu Gly Arg Lys Gly Ala Gln Ile 
    130                 135                 140                 


Val Lys Arg Ala Ser Leu Lys Arg Gly Lys Gln 
145                 150                 155 


<210>  4675
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  4675

Met Trp Thr Phe Val Thr Gln Leu Leu Val Thr Leu Val Leu Leu Ser 
1               5                   10                  15      


Phe Phe Leu Val Ser Cys Gln Asn Val Met His Ile Val Arg Gly Ser 
            20                  25                  30          


Leu Cys Phe Val Leu Lys His Ile His Gln Glu Leu Asp Lys Glu Leu 
        35                  40                  45              


Gly Glu Ser Glu Gly Leu Ser Asp Asp Glu Glu Thr Ile Ser Thr Arg 
    50                  55                  60                  


Val Val Arg Arg Arg Val Phe Leu Lys Gly Asn Glu Phe Gln Asn Ile 
65                  70                  75                  80  


Pro Gly Glu Gln Val Thr Glu Glu Gln Phe Thr Asp Glu Gln Gly Asn 
                85                  90                  95      


Ile Val Thr Lys Lys Asp His Thr Ser Thr Pro Asn Pro 
            100                 105                 


<210>  4676
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  4676

Met Ser Ser Lys Tyr Pro Arg Ser Val Arg Arg Cys Leu Pro Leu Trp 
1               5                   10                  15      


Ala Leu Thr Leu Glu Ala Ala Leu Ile Leu Leu Phe Tyr Phe Phe Thr 
            20                  25                  30          


His Tyr Asp Ala Ser Leu Glu Asp Gln Lys Gly Leu Val Ala Ser Tyr 
        35                  40                  45              


Gln Val Gly Gln Asp Leu Thr Val Met Ala Ala Leu Gly Leu Gly Phe 
    50                  55                  60                  


Leu Thr Ser Asn Phe Arg Arg His Ser Trp Ser Ser Val Ala Phe Asn 
65                  70                  75                  80  


Leu Phe Met Leu Ala Leu Gly Val Gln Trp Ala Ile Leu Leu Asp Gly 
                85                  90                  95      


Phe Leu Ser Gln Phe Pro Pro Gly Lys Val Val Ile Thr Leu Phe Ser 
            100                 105                 110         


Ile Arg Leu Ala Thr Met Ser Ala Met Ser Val Leu Ile Ser Ala Gly 
        115                 120                 125             


Ala Val Leu Gly Lys Val Asn Leu Ala Gln Leu Val Val Met Val Leu 
    130                 135                 140                 


Val Glu Val Thr Ala Leu Gly Thr Leu Arg Met Val Ile Ser Asn Ile 
145                 150                 155                 160 


Phe Asn Thr Asp Tyr His Met Asn Leu Arg His Phe Tyr Val Phe Ala 
                165                 170                 175     


Ala Tyr Phe Gly Leu Thr Val Ala Trp Cys Leu Pro Lys Pro Leu Pro 
            180                 185                 190         


Lys Gly Thr Glu Asp Asn Asp Gln Arg Ala Thr Ile Pro Ser Leu Ser 
        195                 200                 205             


Ala Met Leu Gly Ala Leu Phe Leu Trp Met Phe Trp Pro Ser Val Asn 
    210                 215                 220                 


Ser Ala Leu Leu Arg Ser Pro Ile Gln Arg Lys Asn Ala Met Phe Asn 
225                 230                 235                 240 


Thr Tyr Tyr Ala Leu Ala Val Ser Val Val Thr Ala Ile Ser Gly Ser 
                245                 250                 255     


Ser Leu Ala His Pro Gln Arg Lys Ile Ser Met Thr Tyr Val His Ser 
            260                 265                 270         


Ala Val Leu Ala Gly Gly Val Ala Val Gly Thr Ser Cys His Leu Ile 
        275                 280                 285             


Pro Ser Pro Trp Leu Ala Met Val Leu Gly Leu Val Ala Gly Leu Ile 
    290                 295                 300                 


Ser Ile Gly Gly Ala Lys Cys Leu Pro Val Cys Cys Asn Arg Val Leu 
305                 310                 315                 320 


Gly Ile His His Ile Ser Val Met His Ser Ile Phe Ser Leu Leu Gly 
                325                 330                 335     


Leu Leu Gly Glu Ile Thr Tyr Ile Val Leu Leu Val Leu His Thr Val 
            340                 345                 350         


Trp Asn Gly Asn Gly Met Ile Gly Phe Gln Val Leu Leu Ser Ile Gly 
        355                 360                 365             


Glu Leu Ser Leu Ala Ile Val Ile Ala Leu Thr Ser Gly Leu Leu Thr 
    370                 375                 380                 


Gly Leu Leu Leu Asn Leu Lys Ile Trp Lys Ala Pro His Val Ala Lys 
385                 390                 395                 400 


Tyr Phe Asp Asp Gln Val Phe Trp Lys Phe Pro His Leu Ala Val Gly 
                405                 410                 415     


Phe 
    


<210>  4677
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  4677

Met Ala Ala Leu Gln Lys Ser Val Ser Ser Phe Leu Met Gly Thr Leu 
1               5                   10                  15      


Ala Thr Ser Cys Leu Leu Leu Leu Ala Leu Leu Val Gln Gly Gly Ala 
            20                  25                  30          


Ala Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln 
        35                  40                  45              


Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser 
    50                  55                  60                  


Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe 
65                  70                  75                  80  


His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu 
                85                  90                  95      


Asn Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln 
            100                 105                 110         


Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg 
        115                 120                 125             


Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn 
    130                 135                 140                 


Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu 
145                 150                 155                 160 


Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn 
                165                 170                 175     


Ala Cys Ile 
            


<210>  4678
<211>  1005
<212>  PRT
<213>  Homo sapiens

<400>  4678

Met Ala Pro Ala Arg Gly Arg Leu Pro Pro Ala Leu Trp Val Val Thr 
1               5                   10                  15      


Ala Ala Ala Ala Ala Ala Thr Cys Val Ser Ala Ala Arg Gly Glu Val 
            20                  25                  30          


Asn Leu Leu Asp Thr Ser Thr Ile His Gly Asp Trp Gly Trp Leu Thr 
        35                  40                  45              


Tyr Pro Ala His Gly Trp Asp Ser Ile Asn Glu Val Asp Glu Ser Phe 
    50                  55                  60                  


Gln Pro Ile His Thr Tyr Gln Val Cys Asn Val Met Ser Pro Asn Gln 
65                  70                  75                  80  


Asn Asn Trp Leu Arg Thr Ser Trp Val Pro Arg Asp Gly Ala Arg Arg 
                85                  90                  95      


Val Tyr Ala Glu Ile Lys Phe Thr Leu Arg Asp Cys Asn Ser Met Pro 
            100                 105                 110         


Gly Val Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Leu Glu 
        115                 120                 125             


Ser Asp Arg Asp Leu Gly Ala Ser Thr Gln Glu Ser Gln Phe Leu Lys 
    130                 135                 140                 


Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gly Ala Asp Leu Gly 
145                 150                 155                 160 


Val Arg Arg Leu Lys Leu Asn Thr Glu Val Arg Ser Val Gly Pro Leu 
                165                 170                 175     


Ser Lys Arg Gly Phe Tyr Leu Ala Phe Gln Asp Ile Gly Ala Cys Leu 
            180                 185                 190         


Ala Ile Leu Ser Leu Arg Ile Tyr Tyr Lys Lys Cys Pro Ala Met Val 
        195                 200                 205             


Arg Asn Leu Ala Ala Phe Ser Glu Ala Val Thr Gly Ala Asp Ser Ser 
    210                 215                 220                 


Ser Leu Val Glu Val Arg Gly Gln Cys Val Arg His Ser Glu Glu Arg 
225                 230                 235                 240 


Asp Thr Pro Lys Met Tyr Cys Ser Ala Glu Gly Glu Trp Leu Val Pro 
                245                 250                 255     


Ile Gly Lys Cys Val Cys Ser Ala Gly Tyr Glu Glu Arg Arg Asp Ala 
            260                 265                 270         


Cys Val Ala Cys Glu Leu Gly Phe Tyr Lys Ser Ala Pro Gly Asp Gln 
        275                 280                 285             


Leu Cys Ala Arg Cys Pro Pro His Ser His Ser Ala Ala Pro Ala Ala 
    290                 295                 300                 


Gln Ala Cys His Cys Asp Leu Ser Tyr Tyr Arg Ala Ala Leu Asp Pro 
305                 310                 315                 320 


Pro Ser Ser Ala Cys Thr Arg Pro Pro Ser Ala Pro Val Asn Leu Ile 
                325                 330                 335     


Ser Ser Val Asn Gly Thr Ser Val Thr Leu Glu Trp Ala Pro Pro Leu 
            340                 345                 350         


Asp Pro Gly Gly Arg Ser Asp Ile Thr Tyr Asn Ala Val Cys Arg Arg 
        355                 360                 365             


Cys Pro Trp Ala Leu Ser Arg Cys Glu Ala Cys Gly Ser Gly Thr Arg 
    370                 375                 380                 


Phe Val Pro Gln Gln Thr Ser Leu Val Gln Ala Ser Leu Leu Val Ala 
385                 390                 395                 400 


Asn Leu Leu Ala His Met Asn Tyr Ser Phe Trp Ile Glu Ala Val Asn 
                405                 410                 415     


Gly Val Ser Asp Leu Ser Pro Glu Pro Arg Arg Ala Ala Val Val Asn 
            420                 425                 430         


Ile Thr Thr Asn Gln Ala Ala Pro Ser Gln Val Val Val Ile Arg Gln 
        435                 440                 445             


Glu Arg Ala Gly Gln Thr Ser Val Ser Leu Leu Trp Gln Glu Pro Glu 
    450                 455                 460                 


Gln Pro Asn Gly Ile Ile Leu Glu Tyr Glu Ile Lys Tyr Tyr Glu Lys 
465                 470                 475                 480 


Asp Lys Glu Met Gln Ser Tyr Ser Thr Leu Lys Ala Val Thr Thr Arg 
                485                 490                 495     


Ala Thr Val Ser Gly Leu Lys Pro Gly Thr Arg Tyr Val Phe Gln Val 
            500                 505                 510         


Arg Ala Arg Thr Ser Ala Gly Cys Gly Arg Phe Ser Gln Ala Met Glu 
        515                 520                 525             


Val Glu Thr Gly Lys Pro Arg Pro Arg Tyr Asp Thr Arg Thr Ile Val 
    530                 535                 540                 


Trp Ile Cys Leu Thr Leu Ile Thr Gly Leu Val Val Leu Leu Leu Leu 
545                 550                 555                 560 


Leu Ile Cys Lys Lys Arg His Cys Gly Tyr Ser Lys Ala Phe Gln Asp 
                565                 570                 575     


Ser Asp Glu Glu Lys Met His Tyr Gln Asn Gly Gln Ala Pro Pro Pro 
            580                 585                 590         


Val Phe Leu Pro Leu His His Pro Pro Gly Lys Leu Pro Glu Pro Gln 
        595                 600                 605             


Phe Tyr Ala Glu Pro His Thr Tyr Glu Glu Pro Gly Arg Ala Gly Arg 
    610                 615                 620                 


Ser Phe Thr Arg Glu Ile Glu Ala Ser Arg Ile His Ile Glu Lys Ile 
625                 630                 635                 640 


Ile Gly Ser Gly Asp Ser Gly Glu Val Cys Tyr Gly Arg Leu Arg Val 
                645                 650                 655     


Pro Gly Gln Arg Asp Val Pro Val Ala Ile Lys Ala Leu Lys Ala Gly 
            660                 665                 670         


Tyr Thr Glu Arg Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser Ile Met 
        675                 680                 685             


Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr 
    690                 695                 700                 


Arg Gly Arg Leu Ala Met Ile Val Thr Glu Tyr Met Glu Asn Gly Ser 
705                 710                 715                 720 


Leu Asp Thr Phe Leu Arg Thr His Asp Gly Gln Phe Thr Ile Met Gln 
                725                 730                 735     


Leu Val Gly Met Leu Arg Gly Val Gly Ala Gly Met Arg Tyr Leu Ser 
            740                 745                 750         


Asp Leu Gly Tyr Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val 
        755                 760                 765             


Asp Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val 
    770                 775                 780                 


Leu Glu Asp Asp Pro Asp Ala Ala Tyr Thr Thr Thr Gly Gly Lys Ile 
785                 790                 795                 800 


Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Phe Arg Thr Phe Ser 
                805                 810                 815     


Ser Ala Ser Asp Val Trp Ser Phe Gly Val Val Met Trp Glu Val Leu 
            820                 825                 830         


Ala Tyr Gly Glu Arg Pro Tyr Trp Asn Met Thr Asn Arg Asp Val Ile 
        835                 840                 845             


Ser Ser Val Glu Glu Gly Tyr Arg Leu Pro Ala Pro Met Gly Cys Pro 
    850                 855                 860                 


His Ala Leu His Gln Leu Met Leu Asp Cys Trp His Lys Asp Arg Ala 
865                 870                 875                 880 


Gln Arg Pro Arg Phe Ser Gln Ile Val Ser Val Leu Asp Ala Leu Ile 
                885                 890                 895     


Arg Ser Pro Glu Ser Leu Arg Ala Thr Ala Thr Val Ser Arg Cys Pro 
            900                 905                 910         


Pro Pro Ala Phe Val Arg Ser Cys Phe Asp Leu Arg Gly Gly Ser Gly 
        915                 920                 925             


Gly Gly Gly Gly Leu Thr Val Gly Asp Trp Leu Asp Ser Ile Arg Met 
    930                 935                 940                 


Gly Arg Tyr Arg Asp His Phe Ala Ala Gly Gly Tyr Ser Ser Leu Gly 
945                 950                 955                 960 


Met Val Leu Arg Met Asn Ala Gln Asp Val Arg Ala Leu Gly Ile Thr 
                965                 970                 975     


Leu Met Gly His Gln Lys Lys Ile Leu Gly Ser Ile Gln Thr Met Arg 
            980                 985                 990         


Ala Gln Leu Thr Ser Thr Gln Gly  Pro Arg Arg His Leu  
        995                 1000                 1005 


<210>  4679
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  4679

Met Ser Glu Ala Asp Gly Leu Arg Gln Arg Arg Pro Leu Arg Pro Gln 
1               5                   10                  15      


Val Val Thr Asp Asp Asp Gly Gln Ala Pro Glu Ala Lys Asp Gly Ser 
            20                  25                  30          


Ser Phe Ser Gly Arg Val Phe Arg Val Thr Phe Leu Met Leu Ala Val 
        35                  40                  45              


Ser Leu Thr Val Pro Leu Leu Gly Ala Met Met Leu Leu Glu Ser Pro 
    50                  55                  60                  


Ile Asp Pro Gln Pro Leu Ser Phe Lys Glu Pro Pro Leu Leu Leu Gly 
65                  70                  75                  80  


Val Leu His Pro Asn Thr Lys Leu Arg Gln Ala Glu Arg Leu Phe Glu 
                85                  90                  95      


Asn Gln Leu Val Gly Pro Glu Ser Ile Ala His Ile Gly Asp Val Met 
            100                 105                 110         


Phe Thr Gly Thr Ala Asp Gly Arg Val Val Lys Leu Glu Asn Gly Glu 
        115                 120                 125             


Ile Glu Thr Ile Ala Arg Phe Gly Ser Gly Pro Cys Lys Thr Arg Asp 
    130                 135                 140                 


Asp Glu Pro Val Cys Gly Arg Pro Leu Gly Ile Arg Ala Gly Pro Asn 
145                 150                 155                 160 


Gly Thr Leu Phe Val Ala Asp Ala Tyr Lys Gly Leu Phe Glu Val Asn 
                165                 170                 175     


Pro Trp Lys Arg Glu Val Lys Leu Leu Leu Ser Ser Glu Thr Pro Ile 
            180                 185                 190         


Glu Gly Lys Asn Met Ser Phe Val Asn Asp Leu Thr Val Thr Gln Asp 
        195                 200                 205             


Gly Arg Lys Ile Tyr Phe Thr Asp Ser Ser Ser Lys Trp Gln Arg Arg 
    210                 215                 220                 


Asp Tyr Leu Leu Leu Val Met Glu Gly Thr Asp Asp Gly Arg Leu Leu 
225                 230                 235                 240 


Glu Tyr Asp Thr Val Thr Arg Glu Val Lys Val Leu Leu Asp Gln Leu 
                245                 250                 255     


Arg Phe Pro Asn Gly Val Gln Leu Ser Pro Ala Glu Asp Phe Val Leu 
            260                 265                 270         


Val Ala Glu Thr Thr Met Ala Arg Ile Arg Arg Val Tyr Val Ser Gly 
        275                 280                 285             


Leu Met Lys Gly Gly Ala Asp Leu Phe Val Glu Asn Met Pro Gly Phe 
    290                 295                 300                 


Pro Asp Asn Ile Arg Pro Ser Ser Ser Gly Gly Tyr Trp Val Gly Met 
305                 310                 315                 320 


Ser Thr Ile Arg Pro Asn Pro Gly Phe Ser Met Leu Asp Phe Leu Ser 
                325                 330                 335     


Glu Arg Pro Trp Ile Lys Arg Met Ile Phe Lys Leu Phe Ser Gln Glu 
            340                 345                 350         


Thr Val Met Lys Phe Val Pro Arg Tyr Ser Leu Val Leu Glu Leu Ser 
        355                 360                 365             


Asp Ser Gly Ala Phe Arg Arg Ser Leu His Asp Pro Asp Gly Leu Val 
    370                 375                 380                 


Ala Thr Tyr Ile Ser Glu Val His Glu His Asp Gly His Leu Tyr Leu 
385                 390                 395                 400 


Gly Ser Phe Arg Ser Pro Phe Leu Cys Arg Leu Ser Leu Gln Ala Val 
                405                 410                 415     


<210>  4680
<211>  1192
<212>  PRT
<213>  Homo sapiens

<400>  4680

Met Glu Asp Leu Asp Gln Ser Pro Leu Val Ser Ser Ser Asp Ser Pro 
1               5                   10                  15      


Pro Arg Pro Gln Pro Ala Phe Lys Tyr Gln Phe Val Arg Glu Pro Glu 
            20                  25                  30          


Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Glu Asp 
        35                  40                  45              


Leu Glu Glu Leu Glu Val Leu Glu Arg Lys Pro Ala Ala Gly Leu Ser 
    50                  55                  60                  


Ala Ala Pro Val Pro Thr Ala Pro Ala Ala Gly Ala Pro Leu Met Asp 
65                  70                  75                  80  


Phe Gly Asn Asp Phe Val Pro Pro Ala Pro Arg Gly Pro Leu Pro Ala 
                85                  90                  95      


Ala Pro Pro Val Ala Pro Glu Arg Gln Pro Ser Trp Asp Pro Ser Pro 
            100                 105                 110         


Val Ser Ser Thr Val Pro Ala Pro Ser Pro Leu Ser Ala Ala Ala Val 
        115                 120                 125             


Ser Pro Ser Lys Leu Pro Glu Asp Asp Glu Pro Pro Ala Arg Pro Pro 
    130                 135                 140                 


Pro Pro Pro Pro Ala Ser Val Ser Pro Gln Ala Glu Pro Val Trp Thr 
145                 150                 155                 160 


Pro Pro Ala Pro Ala Pro Ala Ala Pro Pro Ser Thr Pro Ala Ala Pro 
                165                 170                 175     


Lys Arg Arg Gly Ser Ser Gly Ser Val Asp Glu Thr Leu Phe Ala Leu 
            180                 185                 190         


Pro Ala Ala Ser Glu Pro Val Ile Arg Ser Ser Ala Glu Asn Met Asp 
        195                 200                 205             


Leu Lys Glu Gln Pro Gly Asn Thr Ile Ser Ala Gly Gln Glu Asp Phe 
    210                 215                 220                 


Pro Ser Val Leu Leu Glu Thr Ala Ala Ser Leu Pro Ser Leu Ser Pro 
225                 230                 235                 240 


Leu Ser Ala Ala Ser Phe Lys Glu His Glu Tyr Leu Gly Asn Leu Ser 
                245                 250                 255     


Thr Val Leu Pro Thr Glu Gly Thr Leu Gln Glu Asn Val Ser Glu Ala 
            260                 265                 270         


Ser Lys Glu Val Ser Glu Lys Ala Lys Thr Leu Leu Ile Asp Arg Asp 
        275                 280                 285             


Leu Thr Glu Phe Ser Glu Leu Glu Tyr Ser Glu Met Gly Ser Ser Phe 
    290                 295                 300                 


Ser Val Ser Pro Lys Ala Glu Ser Ala Val Ile Val Ala Asn Pro Arg 
305                 310                 315                 320 


Glu Glu Ile Ile Val Lys Asn Lys Asp Glu Glu Glu Lys Leu Val Ser 
                325                 330                 335     


Asn Asn Ile Leu His Asn Gln Gln Glu Leu Pro Thr Ala Leu Thr Lys 
            340                 345                 350         


Leu Val Lys Glu Asp Glu Val Val Ser Ser Glu Lys Ala Lys Asp Ser 
        355                 360                 365             


Phe Asn Glu Lys Arg Val Ala Val Glu Ala Pro Met Arg Glu Glu Tyr 
    370                 375                 380                 


Ala Asp Phe Lys Pro Phe Glu Arg Val Trp Glu Val Lys Asp Ser Lys 
385                 390                 395                 400 


Glu Asp Ser Asp Met Leu Ala Ala Gly Gly Lys Ile Glu Ser Asn Leu 
                405                 410                 415     


Glu Ser Lys Val Asp Lys Lys Cys Phe Ala Asp Ser Leu Glu Gln Thr 
            420                 425                 430         


Asn His Glu Lys Asp Ser Glu Ser Ser Asn Asp Asp Thr Ser Phe Pro 
        435                 440                 445             


Ser Thr Pro Glu Gly Ile Lys Asp Arg Ser Gly Ala Tyr Ile Thr Cys 
    450                 455                 460                 


Ala Pro Phe Asn Pro Ala Ala Thr Glu Ser Ile Ala Thr Asn Ile Phe 
465                 470                 475                 480 


Pro Leu Leu Gly Asp Pro Thr Ser Glu Asn Lys Thr Asp Glu Lys Lys 
                485                 490                 495     


Ile Glu Glu Lys Lys Ala Gln Ile Val Thr Glu Lys Asn Thr Ser Thr 
            500                 505                 510         


Lys Thr Ser Asn Pro Phe Leu Val Ala Ala Gln Asp Ser Glu Thr Asp 
        515                 520                 525             


Tyr Val Thr Thr Asp Asn Leu Thr Lys Val Thr Glu Glu Val Val Ala 
    530                 535                 540                 


Asn Met Pro Glu Gly Leu Thr Pro Asp Leu Val Gln Glu Ala Cys Glu 
545                 550                 555                 560 


Ser Glu Leu Asn Glu Val Thr Gly Thr Lys Ile Ala Tyr Glu Thr Lys 
                565                 570                 575     


Met Asp Leu Val Gln Thr Ser Glu Val Met Gln Glu Ser Leu Tyr Pro 
            580                 585                 590         


Ala Ala Gln Leu Cys Pro Ser Phe Glu Glu Ser Glu Ala Thr Pro Ser 
        595                 600                 605             


Pro Val Leu Pro Asp Ile Val Met Glu Ala Pro Leu Asn Ser Ala Val 
    610                 615                 620                 


Pro Ser Ala Gly Ala Ser Val Ile Gln Pro Ser Ser Ser Pro Leu Glu 
625                 630                 635                 640 


Ala Ser Ser Val Asn Tyr Glu Ser Ile Lys His Glu Pro Glu Asn Pro 
                645                 650                 655     


Pro Pro Tyr Glu Glu Ala Met Ser Val Ser Leu Lys Lys Val Ser Gly 
            660                 665                 670         


Ile Lys Glu Glu Ile Lys Glu Pro Glu Asn Ile Asn Ala Ala Leu Gln 
        675                 680                 685             


Glu Thr Glu Ala Pro Tyr Ile Ser Ile Ala Cys Asp Leu Ile Lys Glu 
    690                 695                 700                 


Thr Lys Leu Ser Ala Glu Pro Ala Pro Asp Phe Ser Asp Tyr Ser Glu 
705                 710                 715                 720 


Met Ala Lys Val Glu Gln Pro Val Pro Asp His Ser Glu Leu Val Glu 
                725                 730                 735     


Asp Ser Ser Pro Asp Ser Glu Pro Val Asp Leu Phe Ser Asp Asp Ser 
            740                 745                 750         


Ile Pro Asp Val Pro Gln Lys Gln Asp Glu Thr Val Met Leu Val Lys 
        755                 760                 765             


Glu Ser Leu Thr Glu Thr Ser Phe Glu Ser Met Ile Glu Tyr Glu Asn 
    770                 775                 780                 


Lys Glu Lys Leu Ser Ala Leu Pro Pro Glu Gly Gly Lys Pro Tyr Leu 
785                 790                 795                 800 


Glu Ser Phe Lys Leu Ser Leu Asp Asn Thr Lys Asp Thr Leu Leu Pro 
                805                 810                 815     


Asp Glu Val Ser Thr Leu Ser Lys Lys Glu Lys Ile Pro Leu Gln Met 
            820                 825                 830         


Glu Glu Leu Ser Thr Ala Val Tyr Ser Asn Asp Asp Leu Phe Ile Ser 
        835                 840                 845             


Lys Glu Ala Gln Ile Arg Glu Thr Glu Thr Phe Ser Asp Ser Ser Pro 
    850                 855                 860                 


Ile Glu Ile Ile Asp Glu Phe Pro Thr Leu Ile Ser Ser Lys Thr Asp 
865                 870                 875                 880 


Ser Phe Ser Lys Leu Ala Arg Glu Tyr Thr Asp Leu Glu Val Ser His 
                885                 890                 895     


Lys Ser Glu Ile Ala Asn Ala Pro Asp Gly Ala Gly Ser Leu Pro Cys 
            900                 905                 910         


Thr Glu Leu Pro His Asp Leu Ser Leu Lys Asn Ile Gln Pro Lys Val 
        915                 920                 925             


Glu Glu Lys Ile Ser Phe Ser Asp Asp Phe Ser Lys Asn Gly Ser Ala 
    930                 935                 940                 


Thr Ser Lys Val Leu Leu Leu Pro Pro Asp Val Ser Ala Leu Ala Thr 
945                 950                 955                 960 


Gln Ala Glu Ile Glu Ser Ile Val Lys Pro Lys Val Leu Val Lys Glu 
                965                 970                 975     


Ala Glu Lys Lys Leu Pro Ser Asp Thr Glu Lys Glu Asp Arg Ser Pro 
            980                 985                 990         


Ser Ala Ile Phe Ser Ala Glu Leu  Ser Lys Thr Ser Val  Val Asp Leu 
        995                 1000                 1005             


Leu Tyr  Trp Arg Asp Ile Lys  Lys Thr Gly Val Val  Phe Gly Ala 
    1010                 1015                 1020             


Ser Leu  Phe Leu Leu Leu Ser  Leu Thr Val Phe Ser  Ile Val Ser 
    1025                 1030                 1035             


Val Thr  Ala Tyr Ile Ala Leu  Ala Leu Leu Ser Val  Thr Ile Ser 
    1040                 1045                 1050             


Phe Arg  Ile Tyr Lys Gly Val  Ile Gln Ala Ile Gln  Lys Ser Asp 
    1055                 1060                 1065             


Glu Gly  His Pro Phe Arg Ala  Tyr Leu Glu Ser Glu  Val Ala Ile 
    1070                 1075                 1080             


Ser Glu  Glu Leu Val Gln Lys  Tyr Ser Asn Ser Ala  Leu Gly His 
    1085                 1090                 1095             


Val Asn  Cys Thr Ile Lys Glu  Leu Arg Arg Leu Phe  Leu Val Asp 
    1100                 1105                 1110             


Asp Leu  Val Asp Ser Leu Lys  Phe Ala Val Leu Met  Trp Val Phe 
    1115                 1120                 1125             


Thr Tyr  Val Gly Ala Leu Phe  Asn Gly Leu Thr Leu  Leu Ile Leu 
    1130                 1135                 1140             


Ala Leu  Ile Ser Leu Phe Ser  Val Pro Val Ile Tyr  Glu Arg His 
    1145                 1150                 1155             


Gln Ala  Gln Ile Asp His Tyr  Leu Gly Leu Ala Asn  Lys Asn Val 
    1160                 1165                 1170             


Lys Asp  Ala Met Ala Lys Ile  Gln Ala Lys Ile Pro  Gly Leu Lys 
    1175                 1180                 1185             


Arg Lys  Ala Glu 
    1190         


<210>  4681
<211>  580
<212>  PRT
<213>  Homo sapiens

<400>  4681

Met Thr Ala Pro Ala Gly Pro Arg Gly Ser Glu Thr Glu Arg Leu Leu 
1               5                   10                  15      


Thr Pro Asn Pro Gly Tyr Gly Thr Gln Ala Gly Pro Ser Pro Ala Pro 
            20                  25                  30          


Pro Thr Pro Pro Glu Glu Glu Asp Leu Arg Arg Arg Leu Lys Tyr Phe 
        35                  40                  45              


Phe Met Ser Pro Cys Asp Lys Phe Arg Ala Lys Gly Arg Lys Pro Cys 
    50                  55                  60                  


Lys Leu Met Leu Gln Val Val Lys Ile Leu Val Val Thr Val Gln Leu 
65                  70                  75                  80  


Ile Leu Phe Gly Leu Ser Asn Gln Leu Ala Val Thr Phe Arg Glu Glu 
                85                  90                  95      


Asn Thr Ile Ala Phe Arg His Leu Phe Leu Leu Gly Tyr Ser Asp Gly 
            100                 105                 110         


Ala Asp Asp Thr Phe Ala Ala Tyr Thr Arg Glu Gln Leu Tyr Gln Ala 
        115                 120                 125             


Ile Phe His Ala Val Asp Gln Tyr Leu Ala Leu Pro Asp Val Ser Leu 
    130                 135                 140                 


Gly Arg Tyr Ala Tyr Val Arg Gly Gly Gly Asp Pro Trp Thr Asn Gly 
145                 150                 155                 160 


Ser Gly Leu Ala Leu Cys Gln Arg Tyr Tyr His Arg Gly His Val Asp 
                165                 170                 175     


Pro Ala Asn Asp Thr Phe Asp Ile Asp Pro Met Val Val Thr Asp Cys 
            180                 185                 190         


Ile Gln Val Asp Pro Pro Glu Arg Pro Pro Pro Pro Pro Ser Asp Asp 
        195                 200                 205             


Leu Thr Leu Leu Glu Ser Ser Ser Ser Tyr Lys Asn Leu Thr Leu Lys 
    210                 215                 220                 


Phe His Lys Leu Val Asn Val Thr Ile His Phe Arg Leu Lys Thr Ile 
225                 230                 235                 240 


Asn Leu Gln Ser Leu Ile Asn Asn Glu Ile Pro Asp Cys Tyr Thr Phe 
                245                 250                 255     


Ser Val Leu Ile Thr Phe Asp Asn Lys Ala His Ser Gly Arg Ile Pro 
            260                 265                 270         


Ile Ser Leu Glu Thr Gln Ala His Ile Gln Glu Cys Lys His Pro Ser 
        275                 280                 285             


Val Phe Gln His Gly Asp Asn Ser Phe Arg Leu Leu Phe Asp Val Val 
    290                 295                 300                 


Val Ile Leu Thr Cys Ser Leu Ser Phe Leu Leu Cys Ala Arg Ser Leu 
305                 310                 315                 320 


Leu Arg Gly Phe Leu Leu Gln Asn Glu Phe Val Gly Phe Met Trp Arg 
                325                 330                 335     


Gln Arg Gly Arg Val Ile Ser Leu Trp Glu Arg Leu Glu Phe Val Asn 
            340                 345                 350         


Gly Trp Tyr Ile Leu Leu Val Thr Ser Asp Val Leu Thr Ile Ser Gly 
        355                 360                 365             


Thr Ile Met Lys Ile Gly Ile Glu Ala Lys Asn Leu Ala Ser Tyr Asp 
    370                 375                 380                 


Val Cys Ser Ile Leu Leu Gly Thr Ser Thr Leu Leu Val Trp Val Gly 
385                 390                 395                 400 


Val Ile Arg Tyr Leu Thr Phe Phe His Asn Tyr Asn Ile Leu Ile Ala 
                405                 410                 415     


Thr Leu Arg Val Ala Leu Pro Ser Val Met Arg Phe Cys Cys Cys Val 
            420                 425                 430         


Ala Val Ile Tyr Leu Gly Tyr Cys Phe Cys Gly Trp Ile Val Leu Gly 
        435                 440                 445             


Pro Tyr His Val Lys Phe Arg Ser Leu Ser Met Val Ser Glu Cys Leu 
    450                 455                 460                 


Phe Ser Leu Ile Asn Gly Asp Asp Met Phe Val Thr Phe Ala Ala Met 
465                 470                 475                 480 


Gln Ala Gln Gln Gly Arg Ser Ser Leu Val Trp Leu Phe Ser Gln Leu 
                485                 490                 495     


Tyr Leu Tyr Ser Phe Ile Ser Leu Phe Ile Tyr Met Val Leu Ser Leu 
            500                 505                 510         


Phe Ile Ala Leu Ile Thr Gly Ala Tyr Asp Thr Ile Lys His Pro Gly 
        515                 520                 525             


Gly Ala Gly Ala Glu Glu Ser Glu Leu Gln Ala Tyr Ile Ala Gln Cys 
    530                 535                 540                 


Gln Asp Ser Pro Thr Ser Gly Lys Phe Arg Arg Gly Ser Gly Ser Ala 
545                 550                 555                 560 


Cys Ser Leu Leu Cys Cys Cys Gly Arg Asp Pro Ser Glu Glu His Ser 
                565                 570                 575     


Leu Leu Val Asn 
            580 


<210>  4682
<211>  1091
<212>  PRT
<213>  Homo sapiens

<400>  4682

Met Trp Gln Glu Ala Met Arg Arg Arg Arg Tyr Leu Arg Asp Arg Ser 
1               5                   10                  15      


Glu Glu Ala Ala Gly Gly Gly Asp Gly Leu Pro Arg Ser Arg Asp Trp 
            20                  25                  30          


Leu Tyr Glu Ser Tyr Tyr Cys Met Ser Gln Gln His Pro Leu Ile Val 
        35                  40                  45              


Phe Leu Leu Leu Ile Val Met Gly Ser Cys Leu Ala Leu Leu Ala Val 
    50                  55                  60                  


Phe Phe Ala Leu Gly Leu Glu Val Glu Asp His Val Ala Phe Leu Ile 
65                  70                  75                  80  


Thr Val Pro Thr Ala Leu Ala Ile Phe Phe Ala Ile Phe Ile Leu Val 
                85                  90                  95      


Cys Ile Glu Ser Val Phe Lys Lys Leu Leu Arg Leu Phe Ser Leu Val 
            100                 105                 110         


Ile Trp Ile Cys Leu Val Ala Met Gly Tyr Leu Phe Met Cys Phe Gly 
        115                 120                 125             


Gly Thr Val Ser Pro Trp Asp Gln Val Ser Phe Phe Leu Phe Ile Ile 
    130                 135                 140                 


Phe Val Val Tyr Thr Met Leu Pro Phe Asn Met Arg Asp Ala Ile Ile 
145                 150                 155                 160 


Ala Ser Val Leu Thr Ser Ser Ser His Thr Ile Val Leu Ser Val Cys 
                165                 170                 175     


Leu Ser Ala Thr Pro Gly Gly Lys Glu His Leu Val Trp Gln Ile Leu 
            180                 185                 190         


Ala Asn Val Ile Ile Phe Ile Cys Gly Asn Leu Ala Gly Ala Tyr His 
        195                 200                 205             


Lys His Leu Met Glu Leu Ala Leu Gln Gln Thr Tyr Gln Asp Thr Cys 
    210                 215                 220                 


Asn Cys Ile Lys Ser Arg Ile Lys Leu Glu Phe Glu Lys Arg Gln Gln 
225                 230                 235                 240 


Glu Arg Leu Leu Leu Ser Leu Leu Pro Ala His Ile Ala Met Glu Met 
                245                 250                 255     


Lys Ala Glu Ile Ile Gln Arg Leu Gln Gly Pro Lys Ala Gly Gln Met 
            260                 265                 270         


Glu Asn Thr Asn Asn Phe His Asn Leu Tyr Val Lys Arg His Thr Asn 
        275                 280                 285             


Val Ser Ile Leu Tyr Ala Asp Ile Val Gly Phe Thr Arg Leu Ala Ser 
    290                 295                 300                 


Asp Cys Ser Pro Gly Glu Leu Val His Met Leu Asn Glu Leu Phe Gly 
305                 310                 315                 320 


Lys Phe Asp Gln Ile Ala Lys Glu Asn Glu Cys Met Arg Ile Lys Ile 
                325                 330                 335     


Leu Gly Asp Cys Tyr Tyr Cys Val Ser Gly Leu Pro Ile Ser Leu Pro 
            340                 345                 350         


Asn His Ala Lys Asn Cys Val Lys Met Gly Leu Asp Met Cys Glu Ala 
        355                 360                 365             


Ile Lys Lys Val Arg Asp Ala Thr Gly Val Asp Ile Asn Met Arg Val 
    370                 375                 380                 


Gly Val His Ser Gly Asn Val Leu Cys Gly Val Ile Gly Leu Gln Lys 
385                 390                 395                 400 


Trp Gln Tyr Asp Val Trp Ser His Asp Val Thr Leu Ala Asn His Met 
                405                 410                 415     


Glu Ala Gly Gly Val Pro Gly Arg Val His Ile Ser Ser Val Thr Leu 
            420                 425                 430         


Glu His Leu Asn Gly Ala Tyr Lys Val Glu Glu Gly Asp Gly Asp Ile 
        435                 440                 445             


Arg Asp Pro Tyr Leu Lys Gln His Leu Val Lys Thr Tyr Phe Val Ile 
    450                 455                 460                 


Asn Pro Lys Gly Glu Arg Arg Ser Pro Gln His Leu Phe Arg Pro Arg 
465                 470                 475                 480 


His Thr Leu Asp Gly Ala Lys Met Arg Ala Ser Val Arg Met Thr Arg 
                485                 490                 495     


Tyr Leu Glu Ser Trp Gly Ala Ala Lys Pro Phe Ala His Leu His His 
            500                 505                 510         


Arg Asp Ser Met Thr Thr Glu Asn Gly Lys Ile Ser Thr Thr Asp Val 
        515                 520                 525             


Pro Met Gly Gln His Asn Phe Gln Asn Arg Thr Leu Arg Thr Lys Ser 
    530                 535                 540                 


Gln Lys Lys Arg Phe Glu Glu Glu Leu Asn Glu Arg Met Ile Gln Ala 
545                 550                 555                 560 


Ile Asp Gly Ile Asn Ala Gln Lys Gln Trp Leu Lys Ser Glu Asp Ile 
                565                 570                 575     


Gln Arg Ile Ser Leu Leu Phe Tyr Asn Lys Val Leu Glu Lys Glu Tyr 
            580                 585                 590         


Arg Ala Thr Ala Leu Pro Ala Phe Lys Tyr Tyr Val Thr Cys Ala Cys 
        595                 600                 605             


Leu Ile Phe Phe Cys Ile Phe Ile Val Gln Ile Leu Val Leu Pro Lys 
    610                 615                 620                 


Thr Ser Val Leu Gly Ile Ser Phe Gly Ala Ala Phe Leu Leu Leu Ala 
625                 630                 635                 640 


Phe Ile Leu Phe Val Cys Phe Ala Gly Gln Leu Leu Gln Cys Ser Lys 
                645                 650                 655     


Lys Ala Ser Pro Leu Leu Met Trp Leu Leu Lys Ser Ser Gly Ile Ile 
            660                 665                 670         


Ala Asn Arg Pro Trp Pro Arg Ile Ser Leu Thr Ile Ile Thr Thr Ala 
        675                 680                 685             


Ile Ile Leu Met Met Ala Val Phe Asn Met Phe Phe Leu Ser Asp Ser 
    690                 695                 700                 


Glu Glu Thr Ile Pro Pro Thr Ala Asn Thr Thr Asn Thr Ser Phe Ser 
705                 710                 715                 720 


Ala Ser Asn Asn Gln Val Ala Ile Leu Arg Ala Gln Asn Leu Phe Phe 
                725                 730                 735     


Leu Pro Tyr Phe Ile Tyr Ser Cys Ile Leu Gly Leu Ile Ser Cys Ser 
            740                 745                 750         


Val Phe Leu Arg Val Asn Tyr Glu Leu Lys Met Leu Ile Met Met Val 
        755                 760                 765             


Ala Leu Val Gly Tyr Asn Thr Ile Leu Leu His Thr His Ala His Val 
    770                 775                 780                 


Leu Gly Asp Tyr Ser Gln Val Leu Phe Glu Arg Pro Gly Ile Trp Lys 
785                 790                 795                 800 


Asp Leu Lys Thr Met Gly Ser Val Ser Leu Ser Ile Phe Phe Ile Thr 
                805                 810                 815     


Leu Leu Val Leu Gly Arg Gln Asn Glu Tyr Tyr Cys Arg Leu Asp Phe 
            820                 825                 830         


Leu Trp Lys Asn Lys Phe Lys Lys Glu Arg Glu Glu Ile Glu Thr Met 
        835                 840                 845             


Glu Asn Leu Asn Arg Val Leu Leu Glu Asn Val Leu Pro Ala His Val 
    850                 855                 860                 


Ala Glu His Phe Leu Ala Arg Ser Leu Lys Asn Glu Glu Leu Tyr His 
865                 870                 875                 880 


Gln Ser Tyr Asp Cys Val Cys Val Met Phe Ala Ser Ile Pro Asp Phe 
                885                 890                 895     


Lys Glu Phe Tyr Thr Glu Ser Asp Val Asn Lys Glu Gly Leu Glu Cys 
            900                 905                 910         


Leu Arg Leu Leu Asn Glu Ile Ile Ala Asp Phe Asp Asp Leu Leu Ser 
        915                 920                 925             


Lys Pro Lys Phe Ser Gly Val Glu Lys Ile Lys Thr Ile Gly Ser Thr 
    930                 935                 940                 


Tyr Met Ala Ala Thr Gly Leu Ser Ala Val Pro Ser Gln Glu His Ser 
945                 950                 955                 960 


Gln Glu Pro Glu Arg Gln Tyr Met His Ile Gly Thr Met Val Glu Phe 
                965                 970                 975     


Ala Phe Ala Leu Val Gly Lys Leu Asp Ala Ile Asn Lys His Ser Phe 
            980                 985                 990         


Asn Asp Phe Lys Leu Arg Val Gly  Ile Asn His Gly Pro  Val Ile Ala 
        995                 1000                 1005             


Gly Val  Ile Gly Ala Gln Lys  Pro Gln Tyr Asp Ile  Trp Gly Asn 
    1010                 1015                 1020             


Thr Val  Asn Val Ala Ser Arg  Met Asp Ser Thr Gly  Val Leu Asp 
    1025                 1030                 1035             


Lys Ile  Gln Val Thr Glu Glu  Thr Ser Leu Val Leu  Gln Thr Leu 
    1040                 1045                 1050             


Gly Tyr  Thr Cys Thr Cys Arg  Gly Ile Ile Asn Val  Lys Gly Lys 
    1055                 1060                 1065             


Gly Asp  Leu Lys Thr Tyr Phe  Val Asn Thr Glu Met  Ser Arg Ser 
    1070                 1075                 1080             


Leu Ser  Gln Ser Asn Val Ala  Ser 
    1085                 1090     


<210>  4683
<211>  573
<212>  PRT
<213>  Homo sapiens

<400>  4683

Met Leu Gly Ser Leu Gly Leu Trp Ala Leu Leu Pro Thr Ala Val Glu 
1               5                   10                  15      


Ala Pro Pro Asn Arg Arg Thr Cys Val Phe Phe Glu Ala Pro Gly Val 
            20                  25                  30          


Arg Gly Ser Thr Lys Thr Leu Gly Glu Leu Leu Asp Thr Gly Thr Glu 
        35                  40                  45              


Leu Pro Arg Ala Ile Arg Cys Leu Tyr Ser Arg Cys Cys Phe Gly Ile 
    50                  55                  60                  


Trp Asn Leu Thr Gln Asp Arg Ala Gln Val Glu Met Gln Gly Cys Arg 
65                  70                  75                  80  


Asp Ser Asp Glu Pro Gly Cys Glu Ser Leu His Cys Asp Pro Ser Pro 
                85                  90                  95      


Arg Ala His Pro Ser Pro Gly Ser Thr Leu Phe Thr Cys Ser Cys Gly 
            100                 105                 110         


Thr Asp Phe Cys Asn Ala Asn Tyr Ser His Leu Pro Pro Pro Gly Ser 
        115                 120                 125             


Pro Gly Thr Pro Gly Ser Gln Gly Pro Gln Ala Ala Pro Gly Glu Ser 
    130                 135                 140                 


Ile Trp Met Ala Leu Val Leu Leu Gly Leu Phe Leu Leu Leu Leu Leu 
145                 150                 155                 160 


Leu Leu Gly Ser Ile Ile Leu Ala Leu Leu Gln Arg Lys Asn Tyr Arg 
                165                 170                 175     


Val Arg Gly Glu Pro Val Pro Glu Pro Arg Pro Asp Ser Gly Arg Asp 
            180                 185                 190         


Trp Ser Val Glu Leu Gln Glu Leu Pro Glu Leu Cys Phe Ser Gln Val 
        195                 200                 205             


Ile Arg Glu Gly Gly His Ala Val Val Trp Ala Gly Gln Leu Gln Gly 
    210                 215                 220                 


Lys Leu Val Ala Ile Lys Ala Phe Pro Pro Arg Ser Val Ala Gln Phe 
225                 230                 235                 240 


Gln Ala Glu Arg Ala Leu Tyr Glu Leu Pro Gly Leu Gln His Asp His 
                245                 250                 255     


Ile Val Arg Phe Ile Thr Ala Ser Arg Gly Gly Pro Gly Arg Leu Leu 
            260                 265                 270         


Ser Gly Pro Leu Leu Val Leu Glu Leu His Pro Lys Gly Ser Leu Cys 
        275                 280                 285             


His Tyr Leu Thr Gln Tyr Thr Ser Asp Trp Gly Ser Ser Leu Arg Met 
    290                 295                 300                 


Ala Leu Ser Leu Ala Gln Gly Leu Ala Phe Leu His Glu Glu Arg Trp 
305                 310                 315                 320 


Gln Asn Gly Gln Tyr Lys Pro Gly Ile Ala His Arg Asp Leu Ser Ser 
                325                 330                 335     


Gln Asn Val Leu Ile Arg Glu Asp Gly Ser Cys Ala Ile Gly Asp Leu 
            340                 345                 350         


Gly Leu Ala Leu Val Leu Pro Gly Leu Thr Gln Pro Pro Ala Trp Thr 
        355                 360                 365             


Pro Thr Gln Pro Gln Gly Pro Ala Ala Ile Met Glu Ala Gly Thr Gln 
    370                 375                 380                 


Arg Tyr Met Ala Pro Glu Leu Leu Asp Lys Thr Leu Asp Leu Gln Asp 
385                 390                 395                 400 


Trp Gly Met Ala Leu Arg Arg Ala Asp Ile Tyr Ser Leu Ala Leu Leu 
                405                 410                 415     


Leu Trp Glu Ile Leu Ser Arg Cys Pro Asp Leu Arg Pro Asp Ser Ser 
            420                 425                 430         


Pro Pro Pro Phe Gln Leu Ala Tyr Glu Ala Glu Leu Gly Asn Thr Pro 
        435                 440                 445             


Thr Ser Asp Glu Leu Trp Ala Leu Ala Val Gln Glu Arg Arg Arg Pro 
    450                 455                 460                 


Tyr Ile Pro Ser Thr Trp Arg Cys Phe Ala Thr Asp Pro Asp Gly Leu 
465                 470                 475                 480 


Arg Glu Leu Leu Glu Asp Cys Trp Asp Ala Asp Pro Glu Ala Arg Leu 
                485                 490                 495     


Thr Ala Glu Cys Val Gln Gln Arg Leu Ala Ala Leu Ala His Pro Gln 
            500                 505                 510         


Glu Ser His Pro Phe Pro Glu Ser Cys Pro Arg Gly Cys Pro Pro Leu 
        515                 520                 525             


Cys Pro Glu Asp Cys Thr Ser Ile Pro Ala Pro Thr Ile Leu Pro Cys 
    530                 535                 540                 


Arg Pro Gln Arg Ser Ala Cys His Phe Ser Val Gln Gln Gly Pro Cys 
545                 550                 555                 560 


Ser Arg Asn Pro Gln Pro Ala Cys Thr Leu Ser Pro Val 
                565                 570             


<210>  4684
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  4684

Met Trp Gly Asp Leu Trp Leu Leu Pro Pro Ala Ser Ala Asn Pro Gly 
1               5                   10                  15      


Thr Gly Thr Glu Ala Glu Phe Glu Lys Ala Ala Glu Glu Val Arg His 
            20                  25                  30          


Leu Lys Thr Lys Pro Ser Asp Glu Glu Met Leu Phe Ile Tyr Gly His 
        35                  40                  45              


Tyr Lys Gln Ala Thr Val Gly Asp Ile Asn Thr Glu Arg Pro Gly Met 
    50                  55                  60                  


Leu Asp Phe Thr Gly Lys Ala Lys Trp Asp Ala Trp Asn Glu Leu Lys 
65                  70                  75                  80  


Gly Thr Ser Lys Glu Asp Ala Met Lys Ala Tyr Ile Asn Lys Val Glu 
                85                  90                  95      


Glu Leu Lys Lys Lys Tyr Gly Ile 
            100                 


<210>  4685
<211>  1072
<212>  PRT
<213>  Homo sapiens

<400>  4685

Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu Tyr Phe Ser 
            20                  25                  30          


Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Ala Ala Gly Thr 
        35                  40                  45              


Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Glu Glu Val Pro 
    50                  55                  60                  


Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr Arg Thr Arg Leu 
65                  70                  75                  80  


His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr Gly Leu Leu Tyr 
                85                  90                  95      


Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys Leu Ser Val Arg 
            100                 105                 110         


Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys Val Phe Leu Ser 
        115                 120                 125             


Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro Gly Cys Ala Arg 
    130                 135                 140                 


Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala Cys Ser Ser Leu 
145                 150                 155                 160 


Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile 
                165                 170                 175     


Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe Arg Leu Leu Pro 
            180                 185                 190         


Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu 
        195                 200                 205             


Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu Glu Val Ser 
    210                 215                 220                 


Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val 
225                 230                 235                 240 


Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val Val Met Val 
                245                 250                 255     


Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr Phe 
            260                 265                 270         


Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe Lys Arg Lys 
        275                 280                 285             


Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala Asp Val Val 
    290                 295                 300                 


Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu Pro 
305                 310                 315                 320 


Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu His Trp Pro Asn 
                325                 330                 335     


Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala Thr Val His 
            340                 345                 350         


Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser Glu Asn Arg 
        355                 360                 365             


Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly Pro 
    370                 375                 380                 


Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val Leu Pro Val 
385                 390                 395                 400 


Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val Ser Arg Arg Ala 
                405                 410                 415     


Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Ala 
            420                 425                 430         


Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly Ala Asn 
        435                 440                 445             


Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser Gly Ile 
    450                 455                 460                 


Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu 
465                 470                 475                 480 


Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg Gln Ala 
                485                 490                 495     


Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala Glu Glu 
            500                 505                 510         


Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg Leu Glu Cys 
        515                 520                 525             


Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg 
    530                 535                 540                 


Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro 
545                 550                 555                 560 


Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val Glu Thr Gln 
                565                 570                 575     


Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser Ile Val Gly 
            580                 585                 590         


Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly Tyr Gly Thr 
        595                 600                 605             


Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu Pro Glu Asp 
    610                 615                 620                 


Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Ala Ala 
625                 630                 635                 640 


Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys 
                645                 650                 655     


Ile His Cys Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala 
            660                 665                 670         


Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser 
        675                 680                 685             


Ser Ser Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val 
    690                 695                 700                 


Ser Val Asp Ala Phe Lys Ile Leu Glu Asp Pro Lys Trp Glu Phe Pro 
705                 710                 715                 720 


Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly 
                725                 730                 735     


Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg Ala Gly Tyr 
            740                 745                 750         


Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Pro Ser Glu 
        755                 760                 765             


Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys Gln Val Asn His 
    770                 775                 780                 


Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu 
785                 790                 795                 800 


Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu 
                805                 810                 815     


Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser Gly Gly Ser 
            820                 825                 830         


Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Ala Leu Thr Met 
        835                 840                 845             


Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Gln Gly Met Gln Tyr 
    850                 855                 860                 


Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn Ile 
865                 870                 875                 880 


Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser 
                885                 890                 895     


Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln Gly Arg 
            900                 905                 910         


Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr 
        915                 920                 925             


Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile 
    930                 935                 940                 


Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu 
945                 950                 955                 960 


Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys 
                965                 970                 975     


Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu Pro 
            980                 985                 990         


Asp Lys Arg Pro Val Phe Ala Asp  Ile Ser Lys Asp Leu  Glu Lys Met 
        995                 1000                 1005             


Met Val  Lys Arg Arg Asp Tyr  Leu Asp Leu Ala Ala  Ser Thr Pro 
    1010                 1015                 1020             


Ser Asp  Ser Leu Ile Tyr Asp  Asp Gly Leu Ser Glu  Glu Glu Thr 
    1025                 1030                 1035             


Pro Leu  Val Asp Cys Asn Asn  Ala Pro Leu Pro Arg  Ala Leu Pro 
    1040                 1045                 1050             


Ser Thr  Trp Ile Glu Asn Lys  Leu Tyr Gly Arg Ile  Ser His Ala 
    1055                 1060                 1065             


Phe Thr  Arg Phe 
    1070         


<210>  4686
<211>  840
<212>  PRT
<213>  Homo sapiens

<400>  4686

Met Val Ser Val Phe Arg Ser Glu Glu Met Cys Leu Ser Gln Leu Phe 
1               5                   10                  15      


Leu Gln Val Glu Ala Ala Tyr Cys Cys Val Ala Glu Leu Gly Glu Leu 
            20                  25                  30          


Gly Leu Val Gln Phe Lys Asp Leu Asn Met Asn Val Asn Ser Phe Gln 
        35                  40                  45              


Arg Lys Phe Val Asn Glu Val Arg Arg Cys Glu Ser Leu Glu Arg Ile 
    50                  55                  60                  


Leu Arg Phe Leu Glu Asp Glu Met Gln Asn Glu Ile Val Val Gln Leu 
65                  70                  75                  80  


Leu Glu Lys Ser Pro Leu Thr Pro Leu Pro Arg Glu Met Ile Thr Leu 
                85                  90                  95      


Glu Thr Val Leu Glu Lys Leu Glu Gly Glu Leu Gln Glu Ala Asn Gln 
            100                 105                 110         


Asn Gln Gln Ala Leu Lys Gln Ser Phe Leu Glu Leu Thr Glu Leu Lys 
        115                 120                 125             


Tyr Leu Leu Lys Lys Thr Gln Asp Phe Phe Glu Thr Glu Thr Asn Leu 
    130                 135                 140                 


Ala Asp Asp Phe Phe Thr Glu Asp Thr Ser Gly Leu Leu Glu Leu Lys 
145                 150                 155                 160 


Ala Val Pro Ala Tyr Met Thr Gly Lys Leu Gly Phe Ile Ala Gly Val 
                165                 170                 175     


Ile Asn Arg Glu Arg Met Ala Ser Phe Glu Arg Leu Leu Trp Arg Ile 
            180                 185                 190         


Cys Arg Gly Asn Val Tyr Leu Lys Phe Ser Glu Met Asp Ala Pro Leu 
        195                 200                 205             


Glu Asp Pro Val Thr Lys Glu Glu Ile Gln Lys Asn Ile Phe Ile Ile 
    210                 215                 220                 


Phe Tyr Gln Gly Glu Gln Leu Arg Gln Lys Ile Lys Lys Ile Cys Asp 
225                 230                 235                 240 


Gly Phe Arg Ala Thr Val Tyr Pro Cys Pro Glu Pro Ala Val Glu Arg 
                245                 250                 255     


Arg Glu Met Leu Glu Ser Val Asn Val Arg Leu Glu Asp Leu Ile Thr 
            260                 265                 270         


Val Ile Thr Gln Thr Glu Ser His Arg Gln Arg Leu Leu Gln Glu Ala 
        275                 280                 285             


Ala Ala Asn Trp His Ser Trp Leu Ile Lys Val Gln Lys Met Lys Ala 
    290                 295                 300                 


Val Tyr His Ile Leu Asn Met Cys Asn Ile Asp Val Thr Gln Gln Cys 
305                 310                 315                 320 


Val Ile Ala Glu Ile Trp Phe Pro Val Ala Asp Ala Thr Arg Ile Lys 
                325                 330                 335     


Arg Ala Leu Glu Gln Gly Met Glu Leu Ser Gly Ser Ser Met Ala Pro 
            340                 345                 350         


Ile Met Thr Thr Val Gln Ser Lys Thr Ala Pro Pro Thr Phe Asn Arg 
        355                 360                 365             


Thr Asn Lys Phe Thr Ala Gly Phe Gln Asn Ile Val Asp Ala Tyr Gly 
    370                 375                 380                 


Val Gly Ser Tyr Arg Glu Ile Asn Pro Ala Pro Tyr Thr Ile Ile Thr 
385                 390                 395                 400 


Phe Pro Phe Leu Phe Ala Val Met Phe Gly Asp Cys Gly His Gly Thr 
                405                 410                 415     


Val Met Leu Leu Ala Ala Leu Trp Met Ile Leu Asn Glu Arg Arg Leu 
            420                 425                 430         


Leu Ser Gln Lys Thr Asp Asn Glu Ile Trp Asn Thr Phe Phe His Gly 
        435                 440                 445             


Arg Tyr Leu Ile Leu Leu Met Gly Ile Phe Ser Ile Tyr Thr Gly Leu 
    450                 455                 460                 


Ile Tyr Asn Asp Cys Phe Ser Lys Ser Leu Asn Ile Phe Gly Ser Ser 
465                 470                 475                 480 


Trp Ser Val Gln Pro Met Phe Arg Asn Gly Thr Trp Asn Thr His Val 
                485                 490                 495     


Met Glu Glu Ser Leu Tyr Leu Gln Leu Asp Pro Ala Ile Pro Gly Val 
            500                 505                 510         


Tyr Phe Gly Asn Pro Tyr Pro Phe Gly Ile Asp Pro Ile Trp Asn Leu 
        515                 520                 525             


Ala Ser Asn Lys Leu Thr Phe Leu Asn Ser Tyr Lys Met Lys Met Ser 
    530                 535                 540                 


Val Ile Leu Gly Ile Val Gln Met Val Phe Gly Val Ile Leu Ser Leu 
545                 550                 555                 560 


Phe Asn His Ile Tyr Phe Arg Arg Thr Leu Asn Ile Ile Leu Gln Phe 
                565                 570                 575     


Ile Pro Glu Met Ile Phe Ile Leu Cys Leu Phe Gly Tyr Leu Val Phe 
            580                 585                 590         


Met Ile Ile Phe Lys Trp Cys Cys Phe Asp Val His Val Ser Gln His 
        595                 600                 605             


Ala Pro Ser Ile Leu Ile His Phe Ile Asn Met Phe Leu Phe Asn Tyr 
    610                 615                 620                 


Ser Asp Ser Ser Asn Ala Pro Leu Tyr Lys His Gln Gln Glu Val Gln 
625                 630                 635                 640 


Ser Phe Phe Val Val Met Ala Leu Ile Ser Val Pro Trp Met Leu Leu 
                645                 650                 655     


Ile Lys Pro Phe Ile Leu Arg Ala Ser His Arg Lys Ser Gln Leu Gln 
            660                 665                 670         


Ala Ser Arg Ile Gln Glu Asp Ala Thr Glu Asn Ile Glu Gly Asp Ser 
        675                 680                 685             


Ser Ser Pro Ser Ser Arg Ser Gly Gln Arg Thr Ser Ala Asp Thr His 
    690                 695                 700                 


Gly Ala Leu Asp Asp His Gly Glu Glu Phe Asn Phe Gly Asp Val Phe 
705                 710                 715                 720 


Val His Gln Ala Ile His Thr Ile Glu Tyr Cys Leu Gly Cys Ile Ser 
                725                 730                 735     


Asn Thr Ala Ser Tyr Leu Arg Leu Trp Ala Leu Ser Leu Ala His Ala 
            740                 745                 750         


Gln Leu Ser Glu Val Leu Trp Thr Met Val Met Asn Ser Gly Leu Gln 
        755                 760                 765             


Thr Arg Gly Trp Gly Gly Ile Val Gly Val Phe Ile Ile Phe Ala Val 
    770                 775                 780                 


Phe Ala Val Leu Thr Val Ala Ile Leu Leu Ile Met Glu Gly Leu Ser 
785                 790                 795                 800 


Ala Phe Leu His Ala Leu Arg Leu His Trp Val Glu Phe Gln Asn Lys 
                805                 810                 815     


Phe Tyr Val Gly Asp Gly Tyr Lys Phe Ser Pro Phe Ser Phe Lys His 
            820                 825                 830         


Ile Leu Asp Gly Thr Ala Glu Glu 
        835                 840 


<210>  4687
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  4687

Met Asn Phe Ile Leu Phe Ile Phe Ile Pro Gly Val Phe Ser Leu Lys 
1               5                   10                  15      


Ser Ser Thr Leu Lys Pro Thr Ile Glu Ala Leu Pro Asn Val Leu Pro 
            20                  25                  30          


Leu Asn Glu Asp Val Asn Lys Gln Glu Glu Lys Asn Glu Asp His Thr 
        35                  40                  45              


Pro Asn Tyr Ala Pro Ala Asn Glu Lys Asn Gly Asn Tyr Tyr Lys Asp 
    50                  55                  60                  


Ile Lys Gln Tyr Val Phe Thr Thr Gln Asn Pro Asn Gly Thr Glu Ser 
65                  70                  75                  80  


Glu Ile Ser Val Arg Ala Thr Thr Asp Leu Asn Phe Ala Leu Lys Asn 
                85                  90                  95      


Asp Lys Thr Val Asn Ala Thr Thr Tyr Glu Lys Ser Thr Ile Glu Glu 
            100                 105                 110         


Glu Thr Thr Thr Ser Glu Pro Ser His Lys Asn Ile Gln Arg Ser Thr 
        115                 120                 125             


Pro Asn Val Pro Ala Phe Trp Thr Met Leu Ala Lys Ala Ile Asn Gly 
    130                 135                 140                 


Thr Ala Val Val Met Asp Asp Lys Asp Gln Leu Phe His Pro Ile Pro 
145                 150                 155                 160 


Glu Ser Asp Val Asn Ala Thr Gln Gly Glu Asn Gln Pro Asp Leu Glu 
                165                 170                 175     


Asp Leu Lys Ile Lys Ile Met Leu Gly Ile Ser Leu Met Thr Leu Leu 
            180                 185                 190         


Leu Phe Val Val Leu Leu Ala Phe Cys Ser Ala Thr Leu Tyr Lys Leu 
        195                 200                 205             


Arg His Leu Ser Tyr Lys Ser Cys Glu Ser Gln Tyr Ser Val Asn Pro 
    210                 215                 220                 


Glu Leu Ala Thr Met Ser Tyr Phe His Pro Ser Glu Gly Val Ser Asp 
225                 230                 235                 240 


Thr Ser Phe Ser Lys Ser Ala Glu Ser Ser Thr Phe Leu Gly Thr Thr 
                245                 250                 255     


Ser Ser Asp Met Arg Arg Ser Gly Thr Arg Thr Ser Glu Ser Lys Ile 
            260                 265                 270         


Met Thr Asp Ile Ile Ser Ile Gly Ser Asp Asn Glu Met His Glu Asn 
        275                 280                 285             


Asp Glu Ser Val Thr Arg 
    290                 


<210>  4688
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  4688

Met Ala Thr Leu Trp Gly Gly Leu Leu Arg Leu Gly Ser Leu Leu Ser 
1               5                   10                  15      


Leu Ser Cys Leu Ala Leu Ser Val Leu Leu Leu Ala Gln Leu Ser Asp 
            20                  25                  30          


Ala Ala Lys Asn Phe Glu Asp Val Arg Cys Lys Cys Ile Cys Pro Pro 
        35                  40                  45              


Tyr Lys Glu Asn Ser Gly His Ile Tyr Asn Lys Asn Ile Ser Gln Lys 
    50                  55                  60                  


Asp Cys Asp Cys Leu His Val Val Glu Pro Met Pro Val Arg Gly Pro 
65                  70                  75                  80  


Asp Val Glu Ala Tyr Cys Leu Arg Cys Glu Cys Lys Tyr Glu Glu Arg 
                85                  90                  95      


Ser Ser Val Thr Ile Lys Val Thr Ile Ile Ile Tyr Leu Ser Ile Leu 
            100                 105                 110         


Gly Leu Leu Leu Leu Tyr Met Val Tyr Leu Thr Leu Val Glu Pro Ile 
        115                 120                 125             


Leu Lys Arg Arg Leu Phe Gly His Ala Gln Leu Ile Gln Ser Asp Asp 
    130                 135                 140                 


Asp Ile Gly Asp His Gln Pro Phe Ala Asn Ala His Asp Val Leu Ala 
145                 150                 155                 160 


Arg Ser Arg Ser Arg Ala Asn Val Leu Asn Lys Val Glu Tyr Ala Gln 
                165                 170                 175     


Gln Arg Trp Lys Leu Gln Val Gln Glu Gln Arg Lys Ser Val Phe Asp 
            180                 185                 190         


Arg His Val Val Leu Ser 
        195             


<210>  4689
<211>  661
<212>  PRT
<213>  Homo sapiens

<400>  4689

Met Thr Gly Gly Arg Phe Asp Phe Asp Asp Gly Gly Thr Tyr Cys Gly 
1               5                   10                  15      


Gly Trp Glu Glu Gly Lys Ala His Gly His Gly Ile Cys Thr Gly Pro 
            20                  25                  30          


Lys Gly Gln Gly Glu Tyr Ser Gly Ser Trp Ser His Gly Phe Glu Val 
        35                  40                  45              


Val Gly Gly Tyr Thr Trp Pro Ser Gly Asn Thr Tyr Gln Gly Tyr Trp 
    50                  55                  60                  


Ala Gln Gly Lys Arg His Gly Leu Gly Val Glu Thr Lys Gly Lys Trp 
65                  70                  75                  80  


Met Tyr Arg Gly Glu Trp Ser His Gly Phe Lys Gly Arg Tyr Gly Val 
                85                  90                  95      


Arg Gln Ser Leu Cys Thr Pro Ala Arg Tyr Glu Gly Thr Trp Ser Asn 
            100                 105                 110         


Gly Leu Gln Asp Gly Tyr Gly Val Glu Thr Tyr Gly Asp Gly Gly Thr 
        115                 120                 125             


Tyr Gln Gly Gln Trp Ala Gly Gly Met Arg His Gly Tyr Gly Val Arg 
    130                 135                 140                 


Gln Ser Val Pro Tyr Gly Met Ala Thr Val Ile Arg Ser Pro Leu Arg 
145                 150                 155                 160 


Thr Ser Leu Ala Ser Leu Arg Ser Glu Gln Ser Asn Gly Ser Val Leu 
                165                 170                 175     


His Asp Ala Ala Ala Ala Ala Asp Ser Pro Ala Gly Thr Arg Gly Gly 
            180                 185                 190         


Phe Val Leu Asn Phe His Ala Asp Ala Glu Leu Ala Gly Lys Lys Lys 
        195                 200                 205             


Gly Gly Leu Phe Arg Arg Gly Ser Leu Leu Gly Ser Met Lys Leu Arg 
    210                 215                 220                 


Lys Ser Glu Ser Lys Ser Ser Ile Ser Ser Lys Arg Ser Ser Val Arg 
225                 230                 235                 240 


Ser Asp Ala Ala Met Ser Arg Ile Ser Ser Ser Asp Ala Asn Ser Thr 
                245                 250                 255     


Ile Ser Phe Gly Asp Val Asp Cys Asp Phe Cys Pro Val Glu Asp His 
            260                 265                 270         


Val Asp Ala Thr Thr Thr Glu Thr Tyr Met Gly Glu Trp Lys Asn Asp 
        275                 280                 285             


Lys Arg Asn Gly Phe Gly Val Ser Glu Arg Ser Asn Gly Met Lys Tyr 
    290                 295                 300                 


Glu Gly Glu Trp Ala Asn Asn Lys Arg His Gly Tyr Gly Cys Thr Val 
305                 310                 315                 320 


Phe Pro Asp Gly Ser Lys Glu Glu Gly Lys Tyr Lys Asn Asn Ile Leu 
                325                 330                 335     


Val Arg Gly Ile Arg Lys Gln Leu Ile Pro Ile Arg His Thr Lys Thr 
            340                 345                 350         


Arg Glu Lys Val Asp Arg Ala Ile Glu Gly Ala Gln Arg Ala Ala Ala 
        355                 360                 365             


Met Ala Arg Thr Lys Val Glu Ile Ala Asn Ser Arg Thr Ala His Ala 
    370                 375                 380                 


Arg Ala Lys Ala Asp Ala Ala Asp Gln Ala Ala Leu Ala Ala Arg Gln 
385                 390                 395                 400 


Glu Cys Asp Ile Ala Arg Ala Val Ala Arg Glu Leu Ser Pro Asp Phe 
                405                 410                 415     


Tyr Gln Pro Gly Pro Asp Tyr Val Lys Gln Arg Phe Gln Glu Gly Val 
            420                 425                 430         


Asp Ala Lys Glu Asn Pro Glu Glu Lys Val Pro Glu Lys Pro Pro Thr 
        435                 440                 445             


Pro Lys Glu Ser Pro His Phe Tyr Arg Lys Gly Thr Thr Pro Pro Arg 
    450                 455                 460                 


Ser Pro Glu Ala Ser Pro Lys His Ser His Ser Pro Ala Ser Ser Pro 
465                 470                 475                 480 


Lys Pro Leu Lys Lys Gln Asn Pro Ser Ser Gly Ala Arg Leu Asn Gln 
                485                 490                 495     


Asp Lys Arg Ser Val Ala Asp Glu Gln Val Thr Ala Ile Val Asn Lys 
            500                 505                 510         


Pro Leu Met Ser Lys Ala Pro Thr Lys Glu Ala Gly Ala Val Val Pro 
        515                 520                 525             


Gln Ser Lys Tyr Ser Gly Arg His His Ile Pro Asn Pro Ser Asn Gly 
    530                 535                 540                 


Glu Leu His Ser Gln Tyr His Gly Tyr Tyr Val Lys Leu Asn Ala Pro 
545                 550                 555                 560 


Gln His Pro Pro Val Asp Val Glu Asp Gly Asp Gly Ser Ser Gln Ser 
                565                 570                 575     


Ser Ser Ala Leu Val His Lys Pro Ser Ala Asn Lys Trp Ser Pro Ser 
            580                 585                 590         


Lys Ser Val Thr Lys Pro Val Ala Lys Glu Ser Lys Ala Glu Pro Lys 
        595                 600                 605             


Ala Lys Lys Ser Glu Leu Ala Ile Pro Lys Asn Pro Ala Ser Asn Asp 
    610                 615                 620                 


Ser Cys Pro Ala Leu Glu Lys Glu Ala Asn Ser Gly Pro Asn Ser Ile 
625                 630                 635                 640 


Met Ile Val Leu Val Met Leu Leu Asn Ile Gly Leu Ala Ile Leu Phe 
                645                 650                 655     


Val His Phe Leu Thr 
            660     


<210>  4690
<211>  748
<212>  PRT
<213>  Homo sapiens

<400>  4690

Met Ser Ser Gly Gly Arg Phe Asn Phe Asp Asp Gly Gly Ser Tyr Cys 
1               5                   10                  15      


Gly Gly Trp Glu Asp Gly Lys Ala His Gly His Gly Val Cys Thr Gly 
            20                  25                  30          


Pro Lys Gly Gln Gly Glu Tyr Thr Gly Ser Trp Ser His Gly Phe Glu 
        35                  40                  45              


Val Leu Gly Val Tyr Thr Trp Pro Ser Gly Asn Thr Tyr Gln Gly Thr 
    50                  55                  60                  


Trp Ala Gln Gly Lys Arg His Gly Ile Gly Leu Glu Ser Lys Gly Lys 
65                  70                  75                  80  


Trp Val Tyr Lys Gly Glu Trp Thr His Gly Phe Lys Gly Arg Tyr Gly 
                85                  90                  95      


Val Arg Glu Cys Ala Gly Asn Gly Ala Lys Tyr Glu Gly Thr Trp Ser 
            100                 105                 110         


Asn Gly Leu Gln Asp Gly Tyr Gly Thr Glu Thr Tyr Ser Asp Gly Gly 
        115                 120                 125             


Thr Tyr Gln Gly Gln Trp Val Gly Gly Met Arg Gln Gly Tyr Gly Val 
    130                 135                 140                 


Arg Gln Ser Val Pro Tyr Gly Met Ala Ala Val Ile Arg Ser Pro Leu 
145                 150                 155                 160 


Arg Thr Ser Ile Asn Ser Leu Arg Ser Glu His Thr Asn Gly Thr Ala 
                165                 170                 175     


Leu His Pro Asp Ala Ser Pro Ala Val Ala Gly Ser Pro Ala Val Ser 
            180                 185                 190         


Arg Gly Gly Phe Val Leu Val Ala His Ser Asp Ser Glu Ile Leu Lys 
        195                 200                 205             


Ser Lys Lys Lys Gly Leu Phe Arg Arg Ser Leu Leu Ser Gly Leu Lys 
    210                 215                 220                 


Leu Arg Lys Ser Glu Ser Lys Ser Ser Leu Ala Ser Gln Arg Ser Lys 
225                 230                 235                 240 


Gln Ser Ser Phe Arg Ser Glu Ala Gly Met Ser Thr Val Ser Ser Thr 
                245                 250                 255     


Ala Ser Asp Ile His Ser Thr Ile Ser Leu Gly Glu Ala Glu Ala Glu 
            260                 265                 270         


Leu Ala Val Ile Glu Asp Asp Ile Asp Ala Thr Thr Thr Glu Thr Tyr 
        275                 280                 285             


Val Gly Glu Trp Lys Asn Asp Lys Arg Ser Gly Phe Gly Val Ser Gln 
    290                 295                 300                 


Arg Ser Asp Gly Leu Lys Tyr Glu Gly Glu Trp Ala Ser Asn Arg Arg 
305                 310                 315                 320 


His Gly Tyr Gly Cys Met Thr Phe Pro Asp Gly Thr Lys Glu Glu Gly 
                325                 330                 335     


Lys Tyr Lys Gln Asn Ile Leu Val Gly Gly Lys Arg Lys Asn Leu Ile 
            340                 345                 350         


Pro Leu Arg Ala Ser Lys Ile Arg Glu Lys Val Asp Arg Ala Val Glu 
        355                 360                 365             


Ala Ala Glu Arg Ala Ala Thr Ile Ala Lys Gln Lys Ala Glu Ile Ala 
    370                 375                 380                 


Ala Ser Arg Thr Ser His Ser Arg Ala Lys Ala Glu Ala Ala Leu Thr 
385                 390                 395                 400 


Ala Ala Gln Lys Ala Gln Glu Glu Ala Arg Ile Ala Arg Ile Thr Ala 
                405                 410                 415     


Lys Glu Phe Ser Pro Ser Phe Gln His Arg Glu Asn Gly Leu Glu Tyr 
            420                 425                 430         


Gln Arg Pro Lys Arg Gln Thr Ser Cys Asp Asp Ile Glu Val Leu Ser 
        435                 440                 445             


Thr Gly Thr Pro Leu Gln Gln Glu Ser Pro Glu Leu Tyr Arg Lys Gly 
    450                 455                 460                 


Thr Thr Pro Ser Asp Leu Thr Pro Asp Asp Ser Pro Leu Gln Ser Phe 
465                 470                 475                 480 


Pro Thr Ser Pro Ala Ala Thr Pro Pro Pro Ala Pro Ala Ala Arg Asn 
                485                 490                 495     


Lys Val Ala His Phe Ser Arg Gln Val Ser Val Asp Glu Glu Arg Gly 
            500                 505                 510         


Gly Asp Ile Gln Met Leu Leu Glu Gly Arg Ala Gly Asp Cys Ala Arg 
        515                 520                 525             


Ser Ser Trp Gly Glu Glu Gln Ala Gly Gly Ser Arg Gly Val Arg Ser 
    530                 535                 540                 


Gly Ala Leu Arg Gly Gly Leu Leu Val Asp Asp Phe Arg Thr Arg Gly 
545                 550                 555                 560 


Ser Gly Arg Lys Gln Pro Gly Asn Pro Lys Pro Arg Glu Arg Arg Thr 
                565                 570                 575     


Glu Ser Pro Pro Val Phe Thr Trp Thr Ser His His Arg Ala Ser Asn 
            580                 585                 590         


His Ser Pro Gly Gly Ser Arg Leu Leu Glu Leu Gln Glu Glu Lys Leu 
        595                 600                 605             


Ser Asn Tyr Arg Met Glu Met Lys Pro Leu Leu Arg Met Glu Thr His 
    610                 615                 620                 


Pro Gln Lys Arg Arg Tyr Ser Lys Gly Gly Ala Cys Arg Gly Leu Gly 
625                 630                 635                 640 


Asp Asp His Arg Pro Glu Asp Arg Gly Phe Gly Val Gln Arg Leu Arg 
                645                 650                 655     


Ser Lys Ala Gln Asn Lys Glu Asn Phe Arg Pro Ala Ser Ser Ala Glu 
            660                 665                 670         


Pro Ala Val Gln Lys Leu Ala Ser Leu Arg Leu Gly Gly Ala Glu Pro 
        675                 680                 685             


Arg Leu Leu Arg Trp Asp Leu Thr Phe Ser Pro Pro Gln Lys Ser Leu 
    690                 695                 700                 


Pro Val Ala Leu Glu Ser Asp Glu Glu Asn Gly Asp Glu Leu Lys Ser 
705                 710                 715                 720 


Ser Thr Gly Ser Ala Pro Ile Leu Val Val Met Val Ile Leu Leu Asn 
                725                 730                 735     


Ile Gly Val Ala Ile Leu Phe Ile Asn Phe Phe Ile 
            740                 745             


<210>  4691
<211>  659
<212>  PRT
<213>  Homo sapiens

<400>  4691

Met Ala Ala Ala Val Leu Met Asp Arg Val Gln Ser Cys Val Thr Phe 
1               5                   10                  15      


Glu Asp Val Phe Val Tyr Phe Ser Arg Glu Glu Trp Glu Leu Leu Glu 
            20                  25                  30          


Glu Ala Gln Arg Phe Leu Tyr Arg Asp Val Met Leu Glu Asn Phe Ala 
        35                  40                  45              


Leu Val Ala Thr Leu Gly Phe Trp Cys Glu Ala Glu His Glu Ala Pro 
    50                  55                  60                  


Ser Glu Gln Ser Val Ser Val Glu Gly Val Ser Gln Val Arg Thr Ala 
65                  70                  75                  80  


Glu Ser Gly Leu Phe Gln Lys Ala His Pro Cys Glu Met Cys Asp Pro 
                85                  90                  95      


Leu Leu Lys Asp Ile Leu His Leu Ala Glu His Gln Gly Ser His Leu 
            100                 105                 110         


Thr Gln Lys Leu Cys Thr Arg Gly Leu Cys Arg Arg Arg Phe Ser Phe 
        115                 120                 125             


Ser Ala Asn Phe Tyr Gln His Gln Lys Gln His Asn Gly Glu Asn Cys 
    130                 135                 140                 


Phe Arg Gly Asp Asp Gly Gly Ala Ser Phe Val Lys Ser Cys Thr Val 
145                 150                 155                 160 


His Met Leu Gly Arg Ser Phe Thr Cys Arg Glu Glu Gly Met Asp Leu 
                165                 170                 175     


Pro Asp Ser Ser Gly Leu Phe Gln His Gln Thr Thr Tyr Asn Arg Val 
            180                 185                 190         


Ser Pro Cys Arg Arg Thr Glu Cys Met Glu Ser Phe Pro His Ser Ser 
        195                 200                 205             


Ser Leu Arg Gln His Gln Gly Asp Tyr Asp Gly Gln Met Leu Phe Ser 
    210                 215                 220                 


Cys Gly Asp Glu Gly Lys Ala Phe Leu Asp Thr Phe Thr Leu Leu Asp 
225                 230                 235                 240 


Ser Gln Met Thr His Ala Glu Val Arg Pro Phe Arg Cys Leu Pro Cys 
                245                 250                 255     


Gly Asn Val Phe Lys Glu Lys Ser Ala Leu Ile Asn His Arg Lys Ile 
            260                 265                 270         


His Ser Gly Glu Ile Ser His Val Cys Lys Glu Cys Gly Lys Ala Phe 
        275                 280                 285             


Ile His Leu His His Leu Lys Met His Gln Lys Phe His Thr Gly Lys 
    290                 295                 300                 


Arg His Tyr Thr Cys Ser Glu Cys Gly Lys Ala Phe Ser Arg Lys Asp 
305                 310                 315                 320 


Thr Leu Val Gln His Gln Arg Val His Thr Gly Glu Arg Ser Tyr Asp 
                325                 330                 335     


Cys Ser Glu Cys Gly Lys Ala Tyr Ser Arg Ser Ser His Leu Val Gln 
            340                 345                 350         


His Gln Arg Ile His Thr Gly Glu Arg Pro Tyr Lys Cys Asn Lys Cys 
        355                 360                 365             


Gly Lys Ala Phe Ser Arg Lys Asp Thr Leu Val Gln His Gln Arg Phe 
    370                 375                 380                 


His Thr Gly Glu Arg Pro Tyr Glu Cys Ser Glu Cys Gly Lys Phe Phe 
385                 390                 395                 400 


Ser Gln Ser Ser His Leu Ile Glu His Trp Arg Ile His Thr Gly Ala 
                405                 410                 415     


Arg Pro Tyr Glu Cys Ile Glu Cys Gly Lys Phe Phe Ser His Asn Ser 
            420                 425                 430         


Ser Leu Ile Lys His Arg Arg Val His Thr Gly Ala Arg Ser Tyr Val 
        435                 440                 445             


Cys Ser Lys Cys Gly Lys Ala Phe Gly Cys Lys Asp Thr Leu Val Gln 
    450                 455                 460                 


His Gln Ile Ile His Thr Gly Ala Arg Pro Tyr Glu Cys Ser Glu Cys 
465                 470                 475                 480 


Gly Lys Ala Phe Ser Arg Lys Asp Thr Leu Val Gln His Gln Lys Ile 
                485                 490                 495     


His Thr Gly Glu Arg Pro Tyr Glu Cys Gly Glu Cys Gly Lys Phe Phe 
            500                 505                 510         


Ser His Ser Ser Asn Leu Ile Val His Gln Arg Ile His Thr Gly Ala 
        515                 520                 525             


Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Cys Phe Ser His Asn Ser 
    530                 535                 540                 


Ser Leu Ile Leu His Gln Arg Val His Thr Gly Ala Arg Pro Tyr Val 
545                 550                 555                 560 


Cys Ser Glu Cys Gly Lys Ala Tyr Ile Ser Ser Ser His Leu Val Gln 
                565                 570                 575     


His Lys Lys Val His Thr Gly Ala Arg Pro Tyr Glu Cys Ser Glu Cys 
            580                 585                 590         


Gly Lys Phe Phe Ser Arg Asn Ser Gly Leu Ile Leu His Gln Arg Val 
        595                 600                 605             


His Thr Gly Glu Lys Pro Tyr Val Cys Ser Glu Cys Gly Lys Ala Tyr 
    610                 615                 620                 


Ser Arg Ser Ser His Leu Val Arg His Gln Lys Ala His Thr Gly Glu 
625                 630                 635                 640 


Arg Ala His Glu Cys Asn Ser Phe Gly Gly Pro Leu Ala Ala Ser Leu 
                645                 650                 655     


Lys Leu Val 
            


<210>  4692
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  4692

Met Gly Ala Pro Pro Gly Tyr Arg Pro Ser Ala Trp Val His Leu Leu 
1               5                   10                  15      


His Gln Leu Pro Arg Ala Asp Phe Gln Leu Arg Pro Val Pro Ser Val 
            20                  25                  30          


Phe Ala Pro Gln Glu Gln Glu Tyr Gln Gln Ala Leu Leu Leu Val Ala 
        35                  40                  45              


Ala Leu Ala Gly Leu Gly Leu Gly Leu Ser Leu Ile Phe Ile Ala Val 
    50                  55                  60                  


Tyr Leu Ile Arg Phe Cys Cys Cys Arg Pro Pro Glu Pro Pro Gly Ser 
65                  70                  75                  80  


Lys Ile Pro Ser Pro Gly Gly Gly Cys Val Thr Trp Ser Cys Ile Val 
                85                  90                  95      


Ala Leu Leu Ala Gly Cys Thr Gly Ile Gly Ile Gly Phe Tyr Gly Asn 
            100                 105                 110         


Ser Glu Thr Ser Asp Gly Val Ser Gln Leu Ser Ser Ala Leu Leu His 
        115                 120                 125             


Ala Asn His Thr Leu Ser Thr Ile Asp His Leu Val Leu Glu Thr Val 
    130                 135                 140                 


Glu Arg Leu Gly Glu Ala Val Arg Thr Glu Leu Thr Thr Leu Glu Glu 
145                 150                 155                 160 


Val Leu Glu Pro Arg Thr Glu Leu Val Ala Ala Ala Arg Gly Ala Arg 
                165                 170                 175     


Arg Gln Ala Glu Ala Ala Ala Gln Gln Leu Gln Gly Leu Ala Phe Trp 
            180                 185                 190         


Gln Gly Val Pro Leu Ser Pro Leu Gln Val Ala Glu Asn Val Ser Phe 
        195                 200                 205             


Val Glu Glu Tyr Arg Trp Leu Ala Tyr Val Leu Leu Leu Leu Leu Glu 
    210                 215                 220                 


Leu Leu Val Cys Leu Phe Thr Leu Leu Gly Leu Ala Lys Gln Ser Lys 
225                 230                 235                 240 


Trp Leu Val Ile Val Met Thr Val Met Ser Leu Leu Val Leu Val Leu 
                245                 250                 255     


Ser Trp Gly Ser Met Gly Leu Glu Ala Ala Thr Ala Val Gly Leu Ser 
            260                 265                 270         


Asp Phe Cys Ser Asn Pro Asp Pro Tyr Val Leu Asn Leu Thr Gln Glu 
        275                 280                 285             


Glu Thr Gly Leu Ser Ser Asp Ile Leu Ser Tyr Tyr Leu Leu Cys Asn 
    290                 295                 300                 


Arg Ala Val Ser Asn Pro Phe Gln Gln Arg Leu Thr Leu Ser Gln Arg 
305                 310                 315                 320 


Ala Leu Ala Asn Ile His Ser Gln Leu Leu Gly Leu Glu Arg Glu Ala 
                325                 330                 335     


Val Pro Gln Phe Pro Ser Ala Gln Lys Pro Leu Leu Ser Leu Glu Glu 
            340                 345                 350         


Thr Leu Asn Val Thr Glu Gly Asn Phe His Gln Leu Val Ala Leu Leu 
        355                 360                 365             


His Cys Arg Ser Leu His Lys Asp Tyr Gly Ala Ala Leu Arg Gly Leu 
    370                 375                 380                 


Cys Glu Asp Ala Leu Glu Gly Leu Leu Phe Leu Leu Leu Phe Ser Leu 
385                 390                 395                 400 


Leu Ser Ala Gly Ala Leu Ala Thr Ala Leu Cys Ser Leu Pro Arg Ala 
                405                 410                 415     


Trp Ala Leu Phe Pro Pro Ser Asp Asp Tyr Asp Asp Thr Asp Asp Asp 
            420                 425                 430         


Asp Pro Phe Asn Pro Gln Glu Ser Lys Arg Phe Val Gln Trp Gln Ser 
        435                 440                 445             


Ser Ile 
    450 


<210>  4693
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  4693

Met Gly Glu Trp Thr Ile Leu Glu Arg Leu Leu Glu Ala Ala Val Gln 
1               5                   10                  15      


Gln His Ser Thr Met Ile Gly Arg Ile Leu Leu Thr Val Val Val Ile 
            20                  25                  30          


Phe Arg Ile Leu Ile Val Ala Ile Val Gly Glu Thr Val Tyr Asp Asp 
        35                  40                  45              


Glu Gln Thr Met Phe Val Cys Asn Thr Leu Gln Pro Gly Cys Asn Gln 
    50                  55                  60                  


Ala Cys Tyr Asp Arg Ala Phe Pro Ile Ser His Ile Arg Tyr Trp Val 
65                  70                  75                  80  


Phe Gln Ile Ile Met Val Cys Thr Pro Ser Leu Cys Phe Ile Thr Tyr 
                85                  90                  95      


Ser Val His Gln Ser Ala Lys Gln Arg Glu Arg Arg Tyr Ser Thr Val 
            100                 105                 110         


Phe Leu Ala Leu Asp Arg Asp Pro Pro Glu Ser Ile Gly Gly Pro Gly 
        115                 120                 125             


Gly Thr Gly Gly Gly Gly Ser Gly Gly Gly Lys Arg Glu Asp Lys Lys 
    130                 135                 140                 


Leu Gln Asn Ala Ile Val Asn Gly Val Leu Gln Asn Thr Glu Asn Thr 
145                 150                 155                 160 


Ser Lys Glu Thr Glu Pro Asp Cys Leu Glu Val Lys Glu Leu Thr Pro 
                165                 170                 175     


His Pro Ser Gly Leu Arg Thr Ala Ser Lys Ser Lys Leu Arg Arg Gln 
            180                 185                 190         


Glu Gly Ile Ser Arg Phe Tyr Ile Ile Gln Val Val Phe Arg Asn Ala 
        195                 200                 205             


Leu Glu Ile Gly Phe Leu Val Gly Gln Tyr Phe Leu Tyr Gly Phe Ser 
    210                 215                 220                 


Val Pro Gly Leu Tyr Glu Cys Asn Arg Tyr Pro Cys Ile Lys Glu Val 
225                 230                 235                 240 


Glu Cys Tyr Val Ser Arg Pro Thr Glu Lys Thr Val Phe Leu Val Phe 
                245                 250                 255     


Met Phe Ala Val Ser Gly Ile Cys Val Val Leu Asn Leu Ala Glu Leu 
            260                 265                 270         


Asn His Leu Gly Trp Arg Lys Ile Lys Leu Ala Val Arg Gly Ala Gln 
        275                 280                 285             


Ala Lys Arg Lys Ser Ile Tyr Glu Ile Arg Asn Lys Asp Leu Pro Arg 
    290                 295                 300                 


Val Ser Val Pro Asn Phe Gly Arg Thr Gln Ser Ser Asp Ser Ala Tyr 
305                 310                 315                 320 


Val 
    


<210>  4694
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  4694

Met Glu Cys Leu Arg Ser Leu Pro Cys Leu Leu Pro Arg Ala Met Arg 
1               5                   10                  15      


Leu Pro Arg Arg Thr Leu Cys Ala Leu Ala Leu Asp Val Thr Ser Val 
            20                  25                  30          


Gly Pro Pro Val Ala Ala Cys Gly Arg Arg Ala Asn Leu Ile Gly Arg 
        35                  40                  45              


Ser Arg Ala Ala Gln Leu Cys Gly Pro Asp Arg Leu Arg Val Ala Gly 
    50                  55                  60                  


Glu Val His Arg Phe Arg Thr Ser Asp Val Ser Gln Ala Thr Leu Ala 
65                  70                  75                  80  


Ser Val Ala Pro Val Phe Thr Val Thr Lys Phe Asp Lys Gln Gly Asn 
                85                  90                  95      


Val Thr Ser Phe Glu Arg Lys Lys Thr Glu Leu Tyr Gln Glu Leu Gly 
            100                 105                 110         


Leu Gln Ala Arg Asp Leu Arg Phe Gln His Val Met Ser Ile Thr Val 
        115                 120                 125             


Arg Asn Asn Arg Ile Ile Met Arg Met Glu Tyr Leu Lys Ala Val Ile 
    130                 135                 140                 


Thr Pro Glu Cys Leu Leu Ile Leu Asp Tyr Arg Asn Leu Asn Leu Glu 
145                 150                 155                 160 


Gln Trp Leu Phe Arg Glu Leu Pro Ser Gln Leu Ser Gly Glu Gly Gln 
                165                 170                 175     


Leu Val Thr Tyr Pro Leu Pro Phe Glu Phe Arg Ala Ile Glu Ala Leu 
            180                 185                 190         


Leu Gln Tyr Trp Ile Asn Thr Leu Gln Gly Lys Leu Ser Ile Leu Gln 
        195                 200                 205             


Pro Leu Ile Leu Glu Thr Leu Asp Ala Leu Val Asp Pro Lys His Ser 
    210                 215                 220                 


Ser Val Asp Arg Ser Lys Leu His Ile Leu Leu Gln Asn Gly Lys Ser 
225                 230                 235                 240 


Leu Ser Glu Leu Glu Thr Asp Ile Lys Ile Phe Lys Glu Ser Ile Leu 
                245                 250                 255     


Glu Ile Leu Asp Glu Glu Glu Leu Leu Glu Glu Leu Cys Val Ser Lys 
            260                 265                 270         


Trp Ser Asp Pro Gln Val Phe Glu Lys Ser Ser Ala Gly Ile Asp His 
        275                 280                 285             


Ala Glu Glu Met Glu Leu Leu Leu Glu Asn Tyr Tyr Arg Leu Ala Asp 
    290                 295                 300                 


Asp Leu Ser Asn Ala Ala Arg Glu Leu Arg Val Leu Ile Asp Asp Ser 
305                 310                 315                 320 


Gln Ser Ile Ile Phe Ile Asn Leu Asp Ser His Arg Asn Val Met Met 
                325                 330                 335     


Arg Leu Asn Leu Gln Leu Thr Met Gly Thr Phe Ser Leu Ser Leu Phe 
            340                 345                 350         


Gly Leu Met Gly Val Ala Phe Gly Met Asn Leu Glu Ser Ser Leu Glu 
        355                 360                 365             


Glu Asp His Arg Ile Phe Trp Leu Ile Thr Gly Ile Met Phe Met Gly 
    370                 375                 380                 


Ser Gly Leu Ile Trp Arg Arg Leu Leu Ser Phe Leu Gly Arg Gln Leu 
385                 390                 395                 400 


Glu Ala Pro Leu Pro Pro Met Met Ala Ser Leu Pro Lys Lys Thr Leu 
                405                 410                 415     


Leu Ala Asp Arg Ser Met Glu Leu Lys Asn Ser Leu Arg Leu Asp Gly 
            420                 425                 430         


Leu Gly Ser Gly Arg Ser Ile Leu Thr Asn Arg 
        435                 440             


<210>  4695
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  4695

Met Leu Trp Leu Leu Phe Phe Leu Val Thr Ala Ile His Ala Glu Leu 
1               5                   10                  15      


Cys Gln Pro Gly Ala Glu Asn Ala Phe Lys Val Arg Leu Ser Ile Arg 
            20                  25                  30          


Thr Ala Leu Gly Asp Lys Ala Tyr Ala Trp Asp Thr Asn Glu Glu Tyr 
        35                  40                  45              


Leu Phe Lys Ala Met Val Ala Phe Ser Met Arg Lys Val Pro Asn Arg 
    50                  55                  60                  


Glu Ala Thr Glu Ile Ser His Val Leu Leu Cys Asn Val Thr Gln Arg 
65                  70                  75                  80  


Val Ser Phe Trp Phe Val Val Thr Asp Pro Ser Lys Asn His Thr Leu 
                85                  90                  95      


Pro Ala Val Glu Val Gln Ser Ala Ile Arg Met Asn Lys Asn Arg Ile 
            100                 105                 110         


Asn Asn Ala Phe Phe Leu Asn Asp Gln Thr Leu Glu Phe Leu Lys Ile 
        115                 120                 125             


Pro Ser Thr Leu Ala Pro Pro Met Asp Pro Ser Val Pro Ile Trp Ile 
    130                 135                 140                 


Ile Ile Phe Gly Val Ile Phe Cys Ile Ile Ile Val Ala Ile Ala Leu 
145                 150                 155                 160 


Leu Ile Leu Ser Gly Ile Trp Gln Arg Arg Arg Lys Asn Lys Glu Pro 
                165                 170                 175     


Ser Glu Val Asp Asp Ala Glu Asp Lys Cys Glu Asn Met Ile Thr Ile 
            180                 185                 190         


Glu Asn Gly Ile Pro Ser Asp Pro Leu Asp Met Lys Gly Gly His Ile 
        195                 200                 205             


Asn Asp Ala Phe Met Thr Glu Asp Glu Arg Leu Thr Pro Leu 
    210                 215                 220         


<210>  4696
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  4696

Met Asp Leu Asp Val Val Asn Met Phe Val Ile Ala Gly Gly Thr Leu 
1               5                   10                  15      


Ala Ile Pro Ile Leu Ala Phe Val Ala Ser Phe Leu Leu Trp Pro Ser 
            20                  25                  30          


Ala Leu Ile Arg Ile Tyr Tyr Trp Tyr Trp Arg Arg Thr Leu Gly Met 
        35                  40                  45              


Gln Val Arg Tyr Val His His Glu Asp Tyr Gln Phe Cys Tyr Ser Phe 
    50                  55                  60                  


Arg Gly Arg Pro Gly His Lys Pro Ser Ile Leu Met Leu His Gly Phe 
65                  70                  75                  80  


Ser Ala His Lys Asp Met Trp Leu Ser Val Val Lys Phe Leu Pro Lys 
                85                  90                  95      


Asn Leu His Leu Val Cys Val Asp Met Pro Gly His Glu Gly Thr Thr 
            100                 105                 110         


Arg Ser Ser Leu Asp Asp Leu Ser Ile Asp Gly Gln Val Lys Arg Ile 
        115                 120                 125             


His Gln Phe Val Glu Cys Leu Lys Leu Asn Lys Lys Pro Phe His Leu 
    130                 135                 140                 


Val Gly Thr Ser Met Gly Gly Gln Val Ala Gly Val Tyr Ala Ala Tyr 
145                 150                 155                 160 


Tyr Pro Ser Asp Val Ser Ser Leu Cys Leu Val Cys Pro Ala Gly Leu 
                165                 170                 175     


Gln Tyr Ser Thr Asp Asn Gln Phe Val Gln Arg Leu Lys Glu Leu Gln 
            180                 185                 190         


Gly Ser Ala Ala Val Glu Lys Ile Pro Leu Ile Pro Ser Thr Pro Glu 
        195                 200                 205             


Glu Met Ser Glu Met Leu Gln Leu Cys Ser Tyr Val Arg Phe Lys Val 
    210                 215                 220                 


Pro Gln Gln Ile Leu Gln Gly Leu Val Asp Val Arg Ile Pro His Asn 
225                 230                 235                 240 


Asn Phe Tyr Arg Lys Leu Phe Leu Glu Ile Val Ser Glu Lys Ser Arg 
                245                 250                 255     


Tyr Ser Leu His Gln Asn Met Asp Lys Ile Lys Val Pro Thr Gln Ile 
            260                 265                 270         


Ile Trp Gly Lys Gln Asp Gln Val Leu Asp Val Ser Gly Ala Asp Met 
        275                 280                 285             


Leu Ala Lys Ser Ile Ala Asn Cys Gln Val Glu Leu Leu Glu Asn Cys 
    290                 295                 300                 


Gly His Ser Val Val Met Glu Arg Pro Arg Lys Thr Ala Lys Leu Ile 
305                 310                 315                 320 


Ile Asp Phe Leu Ala Ser Val His Asn Thr Asp Asn Asn Lys Lys Leu 
                325                 330                 335     


Asp 
    


<210>  4697
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  4697

Met Lys Gly Glu Leu Leu Leu Phe Ser Ser Val Ile Val Leu Leu Gln 
1               5                   10                  15      


Val Val Cys Ser Cys Pro Asp Lys Cys Tyr Cys Gln Ser Ser Thr Asn 
            20                  25                  30          


Phe Val Asp Cys Ser Gln Gln Gly Leu Ala Glu Ile Pro Ser His Leu 
        35                  40                  45              


Pro Pro Gln Thr Arg Thr Leu His Leu Gln Asp Asn Gln Ile His His 
    50                  55                  60                  


Leu Pro Ala Phe Ala Phe Arg Ser Val Pro Trp Leu Met Thr Leu Asn 
65                  70                  75                  80  


Leu Ser Asn Asn Ser Leu Ser Asn Leu Ala Pro Gly Ala Phe His Gly 
                85                  90                  95      


Leu Gln His Leu Gln Val Leu Asn Leu Thr Gln Asn Ser Leu Leu Ser 
            100                 105                 110         


Leu Glu Ser Arg Leu Phe His Ser Leu Pro Gln Leu Arg Glu Leu Asp 
        115                 120                 125             


Leu Ser Ser Asn Asn Ile Ser His Leu Pro Thr Ser Leu Gly Glu Thr 
    130                 135                 140                 


Trp Glu Asn Leu Thr Ile Leu Ala Val Gln Gln Asn Gln Leu Gln Gln 
145                 150                 155                 160 


Leu Asp Arg Ala Leu Leu Glu Ser Met Pro Ser Val Arg Leu Leu Leu 
                165                 170                 175     


Leu Lys Asp Asn Leu Trp Lys Cys Asn Cys His Leu Leu Gly Leu Lys 
            180                 185                 190         


Leu Trp Leu Glu Lys Phe Val Tyr Lys Gly Gly Leu Thr Asp Gly Ile 
        195                 200                 205             


Ile Cys Glu Ser Pro Asp Thr Trp Lys Gly Lys Asp Leu Leu Arg Ile 
    210                 215                 220                 


Pro His Glu Leu Tyr Gln Pro Cys Pro Leu Pro Ala Pro Asp Pro Val 
225                 230                 235                 240 


Ser Ser Gln Ala Gln Trp Pro Gly Ser Ala His Gly Val Val Leu Arg 
                245                 250                 255     


Pro Pro Glu Asn His Asn Ala Gly Glu Arg Glu Leu Leu Glu Cys Glu 
            260                 265                 270         


Leu Lys Pro Lys Pro Arg Pro Ala Asn Leu Arg His Ala Ile Ala Thr 
        275                 280                 285             


Val Ile Ile Thr Gly Val Val Cys Gly Ile Val Cys Leu Met Met Leu 
    290                 295                 300                 


Ala Ala Ala Ile Tyr Gly Cys Thr Tyr Ala Ala Ile Thr Ala Gln Tyr 
305                 310                 315                 320 


His Gly Gly Pro Leu Ala Gln Thr Asn Asp Pro Gly Lys Val Glu Glu 
                325                 330                 335     


Lys Glu Arg Phe Asp Ser Ser Pro Ala 
            340                 345 


<210>  4698
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  4698

Met Pro Asn Asn Ser Thr Ala Leu Ser Leu Ala Asn Val Thr Tyr Ile 
1               5                   10                  15      


Thr Met Glu Ile Phe Ile Gly Leu Cys Ala Ile Val Gly Asn Val Leu 
            20                  25                  30          


Val Ile Cys Val Val Lys Leu Asn Pro Ser Leu Gln Thr Thr Thr Phe 
        35                  40                  45              


Tyr Phe Ile Val Ser Leu Ala Leu Ala Asp Ile Ala Val Gly Val Leu 
    50                  55                  60                  


Val Met Pro Leu Ala Ile Val Val Ser Leu Gly Ile Thr Ile His Phe 
65                  70                  75                  80  


Tyr Ser Cys Leu Phe Met Thr Cys Leu Leu Leu Ile Phe Thr His Ala 
                85                  90                  95      


Ser Ile Met Ser Leu Leu Ala Ile Ala Val Asp Arg Tyr Leu Arg Val 
            100                 105                 110         


Lys Leu Thr Val Arg Phe Arg Ile Pro Gly Leu Pro Gly Cys Ile Leu 
        115                 120                 125             


Ser Phe Gln Leu Lys Val Cys Phe Leu Pro Val Met Trp Leu Phe Ile 
    130                 135                 140                 


Leu Leu Ser Leu Ala Leu Ile Ser Asp Ala Met Val Met Asp Glu Lys 
145                 150                 155                 160 


Val Lys Arg Ser Phe Val Leu Asp Thr Ala Ser Ala Ile Cys Asn Tyr 
                165                 170                 175     


Asn Ala His Tyr Lys Asn His Pro Lys Tyr Trp Cys Arg Gly Tyr Phe 
            180                 185                 190         


Arg Asp Tyr Cys Asn Ile Ile Ala Phe Ser Pro Asn Ser Thr Asn His 
        195                 200                 205             


Val Ala Leu Arg Asp Thr Gly Asn Gln Leu Ile Val Thr Met Ser Cys 
    210                 215                 220                 


Leu Thr Lys Glu Asp Thr Gly Trp Tyr Trp Cys Gly Ile Gln Arg Asp 
225                 230                 235                 240 


Phe Ala Arg Asp Asp Met Asp Phe Thr Glu Leu Ile Val Thr Asp Asp 
                245                 250                 255     


Lys Gly Thr Leu Ala Asn Asp Phe Trp Ser Gly Lys Asp Leu Ser Gly 
            260                 265                 270         


Asn Lys Thr Arg Ser Cys Lys Ala Pro Lys Val Val Arg Lys Ala Asp 
        275                 280                 285             


Arg Ser Arg Thr Ser Ile Leu Ile Ile Cys Ile Leu Ile Thr Gly Leu 
    290                 295                 300                 


Gly Ile Ile Ser Val Ile Ser His Leu Thr Lys Arg Arg Arg Ser Gln 
305                 310                 315                 320 


Arg Asn Arg Arg Val Gly Asn Thr Leu Lys Pro Phe Ser Arg Val Leu 
                325                 330                 335     


Thr Pro Lys Glu Met Ala Pro Thr Glu Gln Met 
            340                 345         


<210>  4699
<211>  644
<212>  PRT
<213>  Homo sapiens

<400>  4699

Met Arg Pro Ser Gly Asp Glu Asp Arg Ala Arg Arg Arg Arg Arg Arg 
1               5                   10                  15      


Arg Arg Arg Arg Asp Leu Leu Leu Ser Gln Leu Cys Phe Leu Ala Ser 
            20                  25                  30          


Val Ala Leu Leu Leu Trp Ser Leu Ser Ser Leu Arg Glu Gln Lys Glu 
        35                  40                  45              


Leu Asp Leu Met Asp Leu Val Gly Glu Asp Arg Lys Trp Met Met Ala 
    50                  55                  60                  


Arg Lys Leu Met Gln Val Asn Asp Thr Leu Thr Ser Glu Asp Ala Gly 
65                  70                  75                  80  


Leu Arg Asn Ser Lys Asn Cys Thr Glu Pro Ala Leu His Glu Phe Pro 
                85                  90                  95      


Asn Asp Ile Phe Thr Asn Glu Asp Arg Arg Gln Gly Ala Val Val Leu 
            100                 105                 110         


His Val Leu Cys Ala Ile Tyr Met Phe Tyr Ala Leu Ala Ile Val Cys 
        115                 120                 125             


Asp Asp Phe Phe Val Pro Ser Leu Glu Lys Ile Cys Glu Arg Leu His 
    130                 135                 140                 


Leu Ser Glu Asp Val Ala Gly Ala Thr Phe Met Ala Ala Gly Ser Ser 
145                 150                 155                 160 


Ala Pro Glu Leu Phe Thr Ser Val Ile Gly Val Phe Ile Thr Lys Gly 
                165                 170                 175     


Asp Val Gly Val Gly Thr Ile Val Gly Ser Ala Val Phe Asn Ile Leu 
            180                 185                 190         


Cys Ile Ile Gly Val Cys Gly Leu Phe Ala Gly Gln Val Val Ala Leu 
        195                 200                 205             


Ser Ser Trp Cys Leu Leu Arg Asp Ser Ile Tyr Tyr Thr Leu Ser Val 
    210                 215                 220                 


Ile Ala Leu Ile Val Phe Ile Tyr Asp Glu Lys Val Ser Trp Trp Glu 
225                 230                 235                 240 


Ser Leu Val Leu Val Leu Met Tyr Leu Ile Tyr Ile Val Ile Met Lys 
                245                 250                 255     


Tyr Asn Ala Cys Ile His Gln Cys Phe Glu Arg Arg Thr Lys Gly Ala 
            260                 265                 270         


Gly Asn Met Val Asn Gly Leu Ala Asn Asn Ala Glu Ile Asp Asp Ser 
        275                 280                 285             


Ser Asn Cys Asp Ala Thr Val Val Leu Leu Lys Lys Ala Asn Phe His 
    290                 295                 300                 


Arg Lys Ala Ser Val Ile Met Val Asp Glu Leu Leu Ser Ala Tyr Pro 
305                 310                 315                 320 


His Gln Leu Ser Phe Ser Glu Ala Gly Leu Arg Ile Met Ile Thr Ser 
                325                 330                 335     


His Phe Pro Pro Lys Thr Arg Leu Ser Met Ala Ser Arg Met Leu Ile 
            340                 345                 350         


Asn Glu Arg Gln Arg Leu Ile Asn Ser Arg Ala Tyr Thr Asn Gly Glu 
        355                 360                 365             


Ser Glu Val Ala Ile Lys Ile Pro Ile Lys His Thr Val Glu Asn Gly 
    370                 375                 380                 


Thr Gly Pro Ser Ser Ala Pro Asp Arg Gly Val Asn Gly Thr Arg Arg 
385                 390                 395                 400 


Asp Asp Val Val Ala Glu Ala Gly Asn Glu Thr Glu Asn Glu Asn Glu 
                405                 410                 415     


Asp Asn Glu Asn Asp Glu Glu Glu Glu Glu Asp Glu Asp Asp Asp Glu 
            420                 425                 430         


Gly Pro Tyr Thr Pro Phe Asp Thr Pro Ser Gly Lys Leu Glu Thr Val 
        435                 440                 445             


Lys Trp Ala Phe Thr Trp Pro Leu Ser Phe Val Leu Tyr Phe Thr Val 
    450                 455                 460                 


Pro Asn Cys Asn Lys Pro Arg Trp Glu Lys Trp Phe Met Val Thr Phe 
465                 470                 475                 480 


Ala Ser Ser Thr Leu Trp Ile Ala Ala Phe Ser Tyr Met Met Val Trp 
                485                 490                 495     


Met Val Thr Ile Ile Gly Tyr Thr Leu Gly Ile Pro Asp Val Ile Met 
            500                 505                 510         


Gly Ile Thr Phe Leu Ala Ala Gly Thr Ser Val Pro Asp Cys Met Ala 
        515                 520                 525             


Ser Leu Ile Val Ala Arg Gln Gly Met Gly Asp Met Ala Val Ser Asn 
    530                 535                 540                 


Ser Ile Gly Ser Asn Val Phe Asp Ile Leu Ile Gly Leu Gly Leu Pro 
545                 550                 555                 560 


Trp Ala Leu Gln Thr Leu Ala Val Asp Tyr Gly Ser Tyr Ile Arg Leu 
                565                 570                 575     


Asn Ser Arg Gly Leu Ile Tyr Ser Val Gly Leu Leu Leu Ala Ser Val 
            580                 585                 590         


Phe Val Thr Val Phe Gly Val His Leu Asn Lys Trp Gln Leu Asp Lys 
        595                 600                 605             


Lys Leu Gly Cys Gly Cys Leu Leu Leu Tyr Gly Val Phe Leu Cys Phe 
    610                 615                 620                 


Ser Ile Met Thr Glu Phe Asn Val Phe Thr Phe Val Asn Leu Pro Met 
625                 630                 635                 640 


Cys Gly Asp His 
                


<210>  4700
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  4700

Met Arg Lys Ile Arg Ala Asn Ala Ile Ala Ile Leu Thr Val Ala Trp 
1               5                   10                  15      


Ile Leu Gly Thr Phe Tyr Tyr Leu Trp Gln Asp Asn Arg Ala His Ala 
            20                  25                  30          


Ala Ser Ser Gly Gly Arg Gly Ala Gln Arg Ala Gly Arg Arg Ser Glu 
        35                  40                  45              


Gln Leu Arg Glu Asp Arg Thr Ile Pro Leu Ile Val Thr Gly Thr Pro 
    50                  55                  60                  


Ser Lys Gly Phe Asp Glu Lys Ala Tyr Leu Ser Ala Lys Gln Leu Lys 
65                  70                  75                  80  


Ala Gly Glu Asp Pro Tyr Arg Gln His Ala Phe Asn Gln Leu Glu Ser 
                85                  90                  95      


Asp Lys Leu Ser Pro Asp Arg Pro Ile Arg Asp Thr Arg His Tyr Ser 
            100                 105                 110         


Cys Pro Ser Val Ser Tyr Ser Ser Asp Leu Pro Ala Thr Ser Val Ile 
        115                 120                 125             


Ile Thr Phe His Asn Glu Ala Arg Ser Thr Leu Leu Arg Thr Val Lys 
    130                 135                 140                 


Ser Val Leu Asn Arg Thr Pro Ala Asn Leu Ile Gln Glu Ile Ile Leu 
145                 150                 155                 160 


Val Asp Asp Phe Ser Ser Asp Pro Glu Asp Cys Leu Leu Leu Thr Arg 
                165                 170                 175     


Ile Pro Lys Val Lys Cys Leu Arg Asn Asp Arg Arg Glu Gly Leu Ile 
            180                 185                 190         


Arg Ser Arg Val Arg Gly Ala Asp Val Ala Ala Ala Thr Val Leu Thr 
        195                 200                 205             


Phe Leu Asp Ser His Cys Glu Val Asn Thr Glu Trp Leu Pro Pro Met 
    210                 215                 220                 


Leu Gln Arg Val Lys Glu Asp His Thr Arg Val Val Ser Pro Ile Ile 
225                 230                 235                 240 


Asp Val Ile Ser Leu Asp Asn Phe Ala Tyr Leu Ala Ala Ser Ala Asp 
                245                 250                 255     


Leu Arg Gly Gly Phe Asp Trp Ser Leu His Phe Lys Trp Glu Gln Ile 
            260                 265                 270         


Pro Leu Glu Gln Lys Met Thr Arg Thr Asp Pro Thr Arg Pro Ile Arg 
        275                 280                 285             


Thr Pro Val Ile Ala Gly Gly Ile Phe Val Ile Asp Lys Ser Trp Phe 
    290                 295                 300                 


Asn His Leu Gly Lys Tyr Asp Ala Gln Met Asp Ile Trp Gly Gly Glu 
305                 310                 315                 320 


Asn Phe Glu Leu Ser Phe Arg Val Trp Met Cys Gly Gly Ser Leu Glu 
                325                 330                 335     


Ile Val Pro Cys Ser Arg Val Gly His Val Phe Arg Lys Arg His Pro 
            340                 345                 350         


Tyr Asn Phe Pro Glu Gly Asn Ala Leu Thr Tyr Ile Arg Asn Thr Lys 
        355                 360                 365             


Arg Thr Ala Glu Val Trp Met Asp Glu Tyr Lys Gln Tyr Tyr Tyr Glu 
    370                 375                 380                 


Ala Arg Pro Ser Ala Ile Gly Lys Ala Phe Gly Ser Val Ala Thr Arg 
385                 390                 395                 400 


Ile Glu Gln Arg Lys Lys Met Asn Cys Lys Ser Phe Arg Trp Tyr Leu 
                405                 410                 415     


Glu Asn Val Tyr Pro Glu Leu Thr Val Pro Val Lys Glu Ala Leu Pro 
            420                 425                 430         


Gly Ile Ile Lys Gln Gly Val Asn Cys Leu Glu Ser Gln Gly Gln Asn 
        435                 440                 445             


Thr Ala Gly Asp Phe Leu Leu Gly Met Gly Ile Cys Arg Gly Ser Ala 
    450                 455                 460                 


Lys Asn Pro Gln Pro Ala Gln Ala Trp Leu Phe Ser Asp His Leu Ile 
465                 470                 475                 480 


Gln Gln Gln Gly Lys Cys Leu Ala Ala Thr Ser Thr Leu Met Ser Ser 
                485                 490                 495     


Pro Gly Ser Pro Val Ile Leu Gln Met Cys Asn Pro Arg Glu Gly Lys 
            500                 505                 510         


Gln Lys Trp Arg Arg Lys Gly Ser Phe Ile Gln His Ser Val Ser Gly 
        515                 520                 525             


Leu Cys Leu Glu Thr Lys Pro Ala Gln Leu Val Thr Ser Lys Cys Gln 
    530                 535                 540                 


Ala Asp Ala Gln Ala Gln Gln Trp Gln Leu Leu Pro His Thr 
545                 550                 555             


<210>  4701
<211>  2113
<212>  PRT
<213>  Homo sapiens

<400>  4701

Met Thr Gly Ala Gly Glu Pro Arg Arg Glu Glu Pro Pro Pro Gln Pro 
1               5                   10                  15      


Ser Ala Gly Leu Arg Ser Arg Glu Ser Gly Ala Pro Ser Ala Gly Gly 
            20                  25                  30          


Trp Glu Arg Ala Glu Arg Gly Arg Gly Ala Ala Ala Arg Pro Ala Thr 
        35                  40                  45              


Gly Pro Pro Pro Arg Arg Ile Gly Pro Leu Tyr Gly Met Trp Leu Val 
    50                  55                  60                  


Thr Phe Leu Leu Leu Leu Asp Ser Leu His Lys Ala Arg Pro Glu Asp 
65                  70                  75                  80  


Val Gly Thr Ser Leu Tyr Phe Val Asn Asp Ser Leu Gln Gln Val Thr 
                85                  90                  95      


Phe Ser Ser Ser Val Gly Val Val Val Pro Cys Pro Ala Ala Gly Ser 
            100                 105                 110         


Pro Ser Ala Ala Leu Arg Trp Tyr Leu Ala Thr Gly Asp Asp Ile Tyr 
        115                 120                 125             


Asp Val Pro His Ile Arg His Val His Ala Asn Gly Thr Leu Gln Leu 
    130                 135                 140                 


Tyr Pro Phe Ser Pro Ser Ala Phe Asn Ser Phe Ile His Asp Asn Asp 
145                 150                 155                 160 


Tyr Phe Cys Thr Ala Glu Asn Ala Ala Gly Lys Ile Arg Ser Pro Asn 
                165                 170                 175     


Ile Arg Val Lys Ala Val Phe Arg Glu Pro Tyr Thr Val Arg Val Glu 
            180                 185                 190         


Asp Gln Arg Ser Met Arg Gly Asn Val Ala Val Phe Lys Cys Leu Ile 
        195                 200                 205             


Pro Ser Ser Val Gln Glu Tyr Val Ser Val Val Ser Trp Glu Lys Asp 
    210                 215                 220                 


Thr Val Ser Ile Ile Pro Glu His Arg Phe Phe Ile Thr Tyr His Gly 
225                 230                 235                 240 


Gly Leu Tyr Ile Ser Asp Val Gln Lys Glu Asp Ala Leu Ser Thr Tyr 
                245                 250                 255     


Arg Cys Ile Thr Lys His Lys Tyr Ser Gly Glu Thr Arg Gln Ser Asn 
            260                 265                 270         


Gly Ala Arg Leu Ser Val Thr Asp Pro Ala Glu Ser Ile Pro Thr Ile 
        275                 280                 285             


Leu Asp Gly Phe His Ser Gln Glu Val Trp Ala Gly His Thr Val Glu 
    290                 295                 300                 


Leu Pro Cys Thr Ala Ser Gly Tyr Pro Ile Pro Ala Ile Arg Trp Leu 
305                 310                 315                 320 


Lys Asp Gly Arg Pro Leu Pro Ala Asp Ser Arg Trp Thr Lys Arg Ile 
                325                 330                 335     


Thr Gly Leu Thr Ile Ser Asp Leu Arg Thr Glu Asp Ser Gly Thr Tyr 
            340                 345                 350         


Ile Cys Glu Val Thr Asn Thr Phe Gly Ser Ala Glu Ala Thr Gly Ile 
        355                 360                 365             


Leu Met Val Ile Asp Pro Leu His Val Thr Leu Thr Pro Lys Lys Leu 
    370                 375                 380                 


Lys Thr Gly Ile Gly Ser Thr Val Ile Leu Ser Cys Ala Leu Thr Gly 
385                 390                 395                 400 


Ser Pro Glu Phe Thr Ile Arg Trp Tyr Arg Asn Thr Glu Leu Val Leu 
                405                 410                 415     


Pro Asp Glu Ala Ile Ser Ile Arg Gly Leu Ser Asn Glu Thr Leu Leu 
            420                 425                 430         


Ile Thr Ser Ala Gln Lys Ser His Ser Gly Ala Tyr Gln Cys Phe Ala 
        435                 440                 445             


Thr Arg Lys Ala Gln Thr Ala Gln Asp Phe Ala Ile Ile Ala Leu Glu 
    450                 455                 460                 


Asp Gly Thr Pro Arg Ile Val Ser Ser Phe Ser Glu Lys Val Val Asn 
465                 470                 475                 480 


Pro Gly Glu Gln Phe Ser Leu Met Cys Ala Ala Lys Gly Ala Pro Pro 
                485                 490                 495     


Pro Thr Val Thr Trp Ala Leu Asp Asp Glu Pro Ile Val Arg Asp Gly 
            500                 505                 510         


Ser His Arg Thr Asn Gln Tyr Thr Met Ser Asp Gly Thr Thr Ile Ser 
        515                 520                 525             


His Met Asn Val Thr Gly Pro Gln Ile Arg Asp Gly Gly Val Tyr Arg 
    530                 535                 540                 


Cys Thr Ala Arg Asn Leu Val Gly Ser Ala Glu Tyr Gln Ala Arg Ile 
545                 550                 555                 560 


Asn Val Arg Gly Pro Pro Ser Ile Arg Ala Met Arg Asn Ile Thr Ala 
                565                 570                 575     


Val Ala Gly Arg Asp Thr Leu Ile Asn Cys Arg Val Ile Gly Tyr Pro 
            580                 585                 590         


Tyr Tyr Ser Ile Lys Trp Tyr Lys Asp Ala Leu Leu Leu Pro Asp Asn 
        595                 600                 605             


His Arg Gln Val Val Phe Glu Asn Gly Thr Leu Lys Leu Thr Asp Val 
    610                 615                 620                 


Gln Lys Gly Met Asp Glu Gly Glu Tyr Leu Cys Ser Val Leu Ile Gln 
625                 630                 635                 640 


Pro Gln Leu Ser Ile Ser Gln Ser Val His Val Ala Val Lys Val Pro 
                645                 650                 655     


Pro Leu Ile Gln Pro Phe Glu Phe Pro Pro Ala Ser Ile Gly Gln Leu 
            660                 665                 670         


Leu Tyr Ile Pro Cys Val Val Ser Ser Gly Asp Met Pro Ile Arg Ile 
        675                 680                 685             


Thr Trp Arg Lys Asp Gly Gln Val Ile Ile Ser Gly Ser Gly Val Thr 
    690                 695                 700                 


Ile Glu Ser Lys Glu Phe Met Ser Ser Leu Gln Ile Ser Ser Val Ser 
705                 710                 715                 720 


Leu Lys His Asn Gly Asn Tyr Thr Cys Ile Ala Ser Asn Ala Ala Ala 
                725                 730                 735     


Thr Val Ser Arg Glu Arg Gln Leu Ile Val Arg Val Pro Pro Arg Phe 
            740                 745                 750         


Val Val Gln Pro Asn Asn Gln Asp Gly Ile Tyr Gly Lys Ala Gly Val 
        755                 760                 765             


Leu Asn Cys Ser Val Asp Gly Tyr Pro Pro Pro Lys Val Met Trp Lys 
    770                 775                 780                 


His Ala Lys Gly Ser Gly Asn Pro Gln Gln Tyr His Pro Val Pro Leu 
785                 790                 795                 800 


Thr Gly Arg Ile Gln Ile Leu Pro Asn Ser Ser Leu Leu Ile Arg His 
                805                 810                 815     


Val Leu Glu Glu Asp Ile Gly Tyr Tyr Leu Cys Gln Ala Ser Asn Gly 
            820                 825                 830         


Val Gly Thr Asp Ile Ser Lys Ser Met Phe Leu Thr Val Lys Ile Pro 
        835                 840                 845             


Ala Met Ile Thr Ser His Pro Asn Thr Thr Ile Ala Ile Lys Gly His 
    850                 855                 860                 


Ala Lys Glu Leu Asn Cys Thr Ala Arg Gly Glu Arg Pro Ile Ile Ile 
865                 870                 875                 880 


Arg Trp Glu Lys Gly Asp Thr Val Ile Asp Pro Asp Arg Val Met Arg 
                885                 890                 895     


Tyr Ala Ile Ala Thr Lys Asp Asn Gly Asp Glu Val Val Ser Thr Leu 
            900                 905                 910         


Lys Leu Lys Pro Ala Asp Arg Gly Asp Ser Val Phe Phe Ser Cys His 
        915                 920                 925             


Ala Ile Asn Ser Tyr Gly Glu Asp Arg Gly Leu Ile Gln Leu Thr Val 
    930                 935                 940                 


Gln Glu Pro Pro Asp Pro Pro Glu Leu Glu Ile Arg Glu Val Lys Ala 
945                 950                 955                 960 


Arg Ser Met Asn Leu Arg Trp Thr Gln Arg Phe Asp Gly Asn Ser Ile 
                965                 970                 975     


Ile Thr Gly Phe Asp Ile Glu Tyr Lys Asn Lys Ser Asp Ser Trp Asp 
            980                 985                 990         


Phe Lys Gln Ser Thr Arg Asn Ile  Ser Pro Thr Ile Asn  Gln Ala Asn 
        995                 1000                 1005             


Ile Val  Asp Leu His Pro Ala  Ser Val Tyr Ser Ile  Arg Met Tyr 
    1010                 1015                 1020             


Ser Phe  Asn Lys Ile Gly Arg  Ser Glu Pro Ser Lys  Glu Leu Thr 
    1025                 1030                 1035             


Ile Ser  Thr Glu Glu Ala Ala  Pro Asp Gly Pro Pro  Met Asp Val 
    1040                 1045                 1050             


Thr Leu  Gln Pro Val Thr Ser  Gln Ser Ile Gln Val  Thr Trp Lys 
    1055                 1060                 1065             


Ala Pro  Lys Lys Glu Leu Gln  Asn Gly Val Ile Arg  Gly Tyr Gln 
    1070                 1075                 1080             


Ile Gly  Tyr Arg Glu Asn Ser  Pro Gly Ser Asn Gly  Gln Tyr Ser 
    1085                 1090                 1095             


Ile Val  Glu Met Lys Ala Thr  Gly Asp Ser Glu Val  Tyr Thr Leu 
    1100                 1105                 1110             


Asp Asn  Leu Lys Lys Phe Ala  Gln Tyr Gly Val Val  Val Gln Ala 
    1115                 1120                 1125             


Phe Asn  Arg Ala Gly Thr Gly  Pro Ser Ser Ser Glu  Ile Asn Ala 
    1130                 1135                 1140             


Thr Thr  Leu Glu Asp Val Pro  Ser Gln Pro Pro Glu  Asn Val Arg 
    1145                 1150                 1155             


Ala Leu  Ser Ile Thr Ser Asp  Val Ala Val Ile Ser  Trp Ser Glu 
    1160                 1165                 1170             


Pro Pro  Arg Ser Thr Leu Asn  Gly Val Leu Lys Gly  Tyr Arg Val 
    1175                 1180                 1185             


Ile Phe  Trp Ser Leu Tyr Val  Asp Gly Glu Trp Gly  Glu Met Gln 
    1190                 1195                 1200             


Asn Ile  Thr Thr Thr Arg Glu  Arg Val Glu Leu Arg  Gly Met Glu 
    1205                 1210                 1215             


Lys Phe  Thr Asn Tyr Ser Val  Gln Val Leu Ala Tyr  Thr Gln Ala 
    1220                 1225                 1230             


Gly Asp  Gly Val Arg Ser Ser  Val Leu Tyr Ile Gln  Thr Lys Glu 
    1235                 1240                 1245             


Asp Val  Pro Gly Pro Pro Ala  Gly Ile Lys Ala Val  Pro Ser Ser 
    1250                 1255                 1260             


Ala Ser  Ser Val Val Val Ser  Trp Leu Pro Pro Thr  Lys Pro Asn 
    1265                 1270                 1275             


Gly Val  Ile Arg Lys Tyr Thr  Ile Phe Cys Ser Ser  Pro Gly Ser 
    1280                 1285                 1290             


Gly Gln  Pro Ala Pro Ser Glu  Tyr Glu Thr Ser Pro  Glu Gln Leu 
    1295                 1300                 1305             


Phe Tyr  Arg Ile Ala His Leu  Asn Arg Gly Gln Gln  Tyr Leu Leu 
    1310                 1315                 1320             


Trp Val  Ala Ala Val Thr Ser  Ala Gly Arg Gly Asn  Ser Ser Glu 
    1325                 1330                 1335             


Lys Val  Thr Ile Glu Pro Ala  Gly Lys Ala Pro Ala  Lys Ile Ile 
    1340                 1345                 1350             


Ser Phe  Gly Gly Thr Val Thr  Thr Pro Trp Met Lys  Asp Val Arg 
    1355                 1360                 1365             


Leu Pro  Cys Asn Ser Val Gly  Asp Pro Ala Pro Ala  Val Lys Trp 
    1370                 1375                 1380             


Thr Lys  Asp Ser Glu Asp Ser  Ala Ile Pro Val Ser  Met Asp Gly 
    1385                 1390                 1395             


His Arg  Leu Ile His Thr Asn  Gly Thr Leu Leu Leu  Arg Ala Val 
    1400                 1405                 1410             


Lys Ala  Glu Asp Ser Gly Tyr  Tyr Thr Cys Thr Ala  Thr Asn Thr 
    1415                 1420                 1425             


Gly Gly  Phe Asp Thr Ile Ile  Val Asn Leu Leu Val  Gln Val Pro 
    1430                 1435                 1440             


Pro Asp  Gln Pro Arg Leu Thr  Val Ser Lys Thr Ser  Ala Ser Ser 
    1445                 1450                 1455             


Ile Thr  Leu Thr Trp Ile Pro  Gly Asp Asn Gly Gly  Ser Ser Ile 
    1460                 1465                 1470             


Arg Gly  Phe Val Leu Gln Tyr  Ser Val Asp Asn Ser  Glu Glu Trp 
    1475                 1480                 1485             


Lys Asp  Val Phe Ile Ser Ser  Ser Glu Arg Ser Phe  Lys Leu Asp 
    1490                 1495                 1500             


Ser Leu  Lys Cys Gly Thr Trp  Tyr Lys Val Lys Leu  Ala Ala Lys 
    1505                 1510                 1515             


Asn Ser  Val Gly Ser Gly Arg  Ile Ser Glu Ile Ile  Glu Ala Lys 
    1520                 1525                 1530             


Thr His  Gly Arg Glu Pro Ser  Phe Ser Lys Asp Gln  His Leu Phe 
    1535                 1540                 1545             


Thr His  Ile Asn Ser Thr His  Ala Arg Leu Asn Leu  Gln Gly Trp 
    1550                 1555                 1560             


Asn Asn  Gly Gly Cys Pro Ile  Thr Ala Ile Val Leu  Glu Tyr Arg 
    1565                 1570                 1575             


Pro Lys  Gly Thr Trp Ala Trp  Gln Gly Leu Arg Ala  Asn Ser Ser 
    1580                 1585                 1590             


Gly Glu  Val Phe Leu Thr Glu  Leu Arg Glu Ala Thr  Trp Tyr Glu 
    1595                 1600                 1605             


Leu Arg  Met Arg Ala Cys Asn  Ser Ala Gly Cys Gly  Asn Glu Thr 
    1610                 1615                 1620             


Ala Gln  Phe Ala Thr Leu Asp  Tyr Asp Gly Ser Thr  Ile Pro Pro 
    1625                 1630                 1635             


Ile Lys  Ser Ala Gln Gly Glu  Gly Asp Asp Val Lys  Lys Leu Phe 
    1640                 1645                 1650             


Thr Ile  Gly Cys Pro Val Ile  Leu Ala Thr Leu Gly  Val Ala Leu 
    1655                 1660                 1665             


Leu Phe  Ile Val Arg Lys Lys  Arg Lys Glu Lys Arg  Leu Lys Arg 
    1670                 1675                 1680             


Leu Arg  Asp Ala Lys Ser Leu  Ala Glu Met Leu Ile  Ser Lys Asn 
    1685                 1690                 1695             


Asn Arg  Ser Phe Asp Thr Pro  Val Lys Gly Pro Pro  Gln Gly Pro 
    1700                 1705                 1710             


Arg Leu  His Ile Asp Ile Pro  Arg Val Gln Leu Leu  Ile Glu Asp 
    1715                 1720                 1725             


Lys Glu  Gly Ile Lys Gln Leu  Gly Asp Asp Lys Ala  Thr Ile Pro 
    1730                 1735                 1740             


Val Thr  Asp Ala Glu Phe Ser  Gln Ala Val Asn Pro  Gln Ser Phe 
    1745                 1750                 1755             


Cys Thr  Gly Val Ser Leu His  His Pro Thr Leu Ile  Gln Ser Thr 
    1760                 1765                 1770             


Gly Pro  Leu Ile Asp Met Ser  Asp Ile Arg Pro Gly  Thr Asn Pro 
    1775                 1780                 1785             


Val Ser  Arg Lys Asn Val Lys  Ser Ala His Ser Thr  Arg Asn Arg 
    1790                 1795                 1800             


Tyr Ser  Ser Gln Trp Thr Leu  Thr Lys Cys Gln Ala  Ser Thr Pro 
    1805                 1810                 1815             


Ala Arg  Thr Leu Thr Ser Asp  Trp Arg Thr Val Gly  Ser Gln His 
    1820                 1825                 1830             


Gly Val  Thr Val Thr Glu Ser  Asp Ser Tyr Ser Ala  Ser Leu Ser 
    1835                 1840                 1845             


Gln Asp  Thr Asp Lys Gly Arg  Asn Ser Met Val Ser  Thr Glu Ser 
    1850                 1855                 1860             


Ala Ser  Ser Thr Tyr Glu Glu  Leu Ala Arg Ala Tyr  Glu His Ala 
    1865                 1870                 1875             


Lys Leu  Glu Glu Gln Leu Gln  His Ala Lys Phe Glu  Ile Thr Glu 
    1880                 1885                 1890             


Cys Phe  Ile Ser Asp Ser Ser  Ser Asp Gln Met Thr  Thr Gly Thr 
    1895                 1900                 1905             


Asn Glu  Asn Ala Asp Ser Met  Thr Ser Met Ser Thr  Pro Ser Glu 
    1910                 1915                 1920             


Pro Gly  Ile Cys Arg Phe Thr  Ala Ser Pro Pro Lys  Pro Gln Asp 
    1925                 1930                 1935             


Ala Asp  Arg Gly Lys Asn Val  Ala Val Pro Ile Pro  His Arg Ala 
    1940                 1945                 1950             


Asn Lys  Ser Asp Tyr Cys Asn  Leu Pro Leu Tyr Ala  Lys Ser Glu 
    1955                 1960                 1965             


Ala Phe  Phe Arg Lys Ala Asp  Gly Arg Glu Pro Cys  Pro Val Val 
    1970                 1975                 1980             


Pro Pro  Arg Glu Ala Ser Ile  Arg Asn Leu Ala Arg  Thr Tyr His 
    1985                 1990                 1995             


Thr Gln  Ala Arg His Leu Thr  Leu Asp Pro Ala Ser  Lys Ser Leu 
    2000                 2005                 2010             


Gly Leu  Pro His Pro Gly Ala  Pro Ala Ala Ala Ser  Thr Ala Thr 
    2015                 2020                 2025             


Leu Pro  Gln Arg Thr Leu Ala  Met Pro Ala Pro Pro  Ala Gly Thr 
    2030                 2035                 2040             


Ala Pro  Pro Ala Pro Gly Pro  Thr Pro Ala Glu Pro  Pro Thr Ala 
    2045                 2050                 2055             


Pro Ser  Ala Ala Pro Pro Ala  Pro Ser Thr Glu Pro  Pro Arg Ala 
    2060                 2065                 2070             


Gly Gly  Pro His Thr Lys Met  Gly Gly Ser Arg Asp  Ser Leu Leu 
    2075                 2080                 2085             


Glu Met  Ser Thr Ser Gly Val  Gly Arg Ser Gln Lys  Gln Gly Ala 
    2090                 2095                 2100             


Gly Ala  Tyr Ser Lys Ser Tyr  Thr Leu Val 
    2105                 2110             


<210>  4702
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  4702

Met Thr Gly Gln Ser Leu Trp Asp Val Ser Glu Ala Asn Val Glu Asp 
1               5                   10                  15      


Gly Glu Ile Arg Ile Asn Val Gly Gly Phe Lys Arg Arg Leu Arg Ser 
            20                  25                  30          


His Thr Leu Leu Arg Phe Pro Glu Thr Arg Leu Gly Arg Leu Leu Leu 
        35                  40                  45              


Cys His Ser Arg Glu Ala Ile Leu Glu Leu Cys Asp Asp Tyr Asp Asp 
    50                  55                  60                  


Val Gln Arg Glu Phe Tyr Phe Asp Arg Asn Pro Glu Leu Phe Pro Tyr 
65                  70                  75                  80  


Val Leu His Phe Tyr His Thr Gly Lys Leu His Val Met Ala Glu Leu 
                85                  90                  95      


Cys Val Phe Ser Phe Ser Gln Glu Ile Glu Tyr Trp Gly Ile Asn Glu 
            100                 105                 110         


Phe Phe Ile Asp Ser Cys Cys Ser Tyr Ser Tyr His Gly Arg Lys Val 
        115                 120                 125             


Glu Pro Glu Gln Glu Lys Trp Asp Glu Gln Ser Asp Gln Glu Ser Thr 
    130                 135                 140                 


Thr Ser Ser Phe Asp Glu Ile Leu Ala Phe Tyr Asn Asp Ala Ser Lys 
145                 150                 155                 160 


Phe Asp Gly Gln Pro Leu Gly Asn Phe Arg Arg Gln Leu Trp Leu Ala 
                165                 170                 175     


Leu Asp Asn Pro Gly Tyr Ser Val Leu Ser Arg Val Phe Ser Ile Leu 
            180                 185                 190         


Ser Ile Leu Val Val Met Gly Ser Ile Ile Thr Met Cys Leu Asn Ser 
        195                 200                 205             


Leu Pro Asp Phe Gln Ile Pro Asp Ser Gln Gly Asn Pro Gly Glu Asp 
    210                 215                 220                 


Pro Arg Phe Glu Ile Val Glu His Phe Gly Ile Ala Trp Phe Thr Phe 
225                 230                 235                 240 


Glu Leu Val Ala Arg Phe Ala Val Ala Pro Asp Phe Leu Lys Phe Phe 
                245                 250                 255     


Lys Asn Ala Leu Asn Leu Ile Asp Leu Met Ser Ile Val Pro Phe Tyr 
            260                 265                 270         


Ile Thr Leu Val Val Asn Leu Val Val Glu Ser Thr Pro Thr Leu Ala 
        275                 280                 285             


Asn Leu Gly Arg Val Ala Gln Val Leu Arg Leu Met Arg Ile Phe Arg 
    290                 295                 300                 


Ile Leu Lys Leu Ala Arg His Ser Thr Gly Leu Arg Ser Leu Gly Ala 
305                 310                 315                 320 


Thr Leu Lys Tyr Ser Tyr Lys Glu Val Gly Leu Leu Leu Leu Tyr Leu 
                325                 330                 335     


Ser Val Gly Ile Ser Ile Phe Ser Val Val Ala Tyr Thr Ile Glu Lys 
            340                 345                 350         


Glu Glu Asn Glu Gly Leu Ala Thr Ile Pro Ala Cys Trp Trp Trp Ala 
        355                 360                 365             


Thr Val Ser Met Thr Thr Val Gly Tyr Gly Asp Val Val Pro Gly Thr 
    370                 375                 380                 


Thr Ala Gly Lys Leu Thr Ala Ser Ala Cys Ile Leu Ala Gly Ile Leu 
385                 390                 395                 400 


Val Val Val Leu Pro Ile Thr Leu Ile Phe Asn Lys Phe Ser His Phe 
                405                 410                 415     


Tyr Arg Arg Gln Lys Gln Leu Glu Ser Ala Met Arg Ser Cys Asp Phe 
            420                 425                 430         


Gly Asp Gly Met Lys Glu Val Pro Ser Val Asn Leu Arg Asp Tyr Tyr 
        435                 440                 445             


Ala His Lys Val Lys Ser Leu Met Ala Ser Leu Thr Asn Met Ser Arg 
    450                 455                 460                 


Ser Ser Pro Ser Glu Leu Ser Leu Asn Asp Ser Leu Arg 
465                 470                 475         


<210>  4703
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  4703

Met Pro Gly Ser Asp Thr Ala Leu Thr Val Asp Arg Thr Tyr Ser Asp 
1               5                   10                  15      


Pro Gly Arg His His Arg Cys Lys Ser Arg Val Glu Arg His Asp Met 
            20                  25                  30          


Asn Thr Leu Ser Leu Pro Leu Asn Ile Arg Arg Gly Gly Ser Asp Thr 
        35                  40                  45              


Asn Leu Asn Phe Asp Val Pro Asp Gly Ile Leu Asp Phe His Lys Val 
    50                  55                  60                  


Lys Leu Thr Ala Asp Ser Leu Lys Gln Lys Ile Leu Lys Val Thr Glu 
65                  70                  75                  80  


Gln Ile Lys Ile Glu Gln Thr Ser Arg Asp Gly Asn Val Ala Glu Tyr 
                85                  90                  95      


Leu Lys Leu Val Asn Asn Ala Asp Lys Gln Gln Ala Gly Arg Ile Lys 
            100                 105                 110         


Gln Val Phe Glu Lys Lys Asn Gln Lys Ser Ala His Ser Ile Ala Gln 
        115                 120                 125             


Leu Gln Lys Lys Leu Glu Gln Tyr His Arg Lys Leu Arg Glu Ile Glu 
    130                 135                 140                 


Gln Asn Gly Ala Ser Arg Ser Ser Lys Asp Ile Ser Lys Asp His Leu 
145                 150                 155                 160 


Lys Asp Ile His Arg Ser Leu Lys Asp Ala His Val Lys Ser Arg Thr 
                165                 170                 175     


Ala Pro His Cys Met Glu Ser Ser Lys Ser Gly Met Pro Gly Val Ser 
            180                 185                 190         


Leu Thr Pro Pro Val Phe Val Phe Asn Lys Ser Arg Glu Phe Ala Asn 
        195                 200                 205             


Leu Ile Arg Asn Lys Phe Gly Ser Ala Asp Asn Ile Ala His Leu Lys 
    210                 215                 220                 


Asn Ser Leu Glu Glu Phe Arg Pro Glu Ala Ser Ala Arg Ala Tyr Gly 
225                 230                 235                 240 


Gly Ser Ala Thr Ile Val Asn Lys Pro Lys Tyr Gly Ser Asp Asp Glu 
                245                 250                 255     


Cys Ser Ser Gly Thr Ser Gly Ser Ala Asp Ser Asn Gly Asn Gln Ser 
            260                 265                 270         


Phe Gly Ala Gly Gly Ala Ser Thr Leu Asp Ser Gln Gly Lys Leu Ala 
        275                 280                 285             


Val Ile Leu Glu Glu Leu Arg Glu Ile Lys Asp Thr Gln Ala Gln Leu 
    290                 295                 300                 


Ala Glu Asp Ile Glu Ala Leu Lys Val Gln Phe Lys Arg Glu Tyr Gly 
305                 310                 315                 320 


Phe Ile Ser Gln Thr Leu Gln Glu Glu Arg Tyr Arg Tyr Glu Arg Leu 
                325                 330                 335     


Glu Asp Gln Leu His Asp Leu Thr Asp Leu His Gln His Glu Thr Ala 
            340                 345                 350         


Asn Leu Lys Gln Glu Leu Ala Ser Ile Glu Glu Lys Val Ala Tyr Gln 
        355                 360                 365             


Ala Tyr Glu Arg Ser Arg Asp Ile Gln Glu Ala Leu Glu Ser Cys Gln 
    370                 375                 380                 


Thr Arg Ile Ser Lys Leu Glu Leu His Gln Gln Glu Gln Gln Ala Leu 
385                 390                 395                 400 


Gln Thr Asp Thr Val Asn Ala Lys Val Leu Leu Gly Arg Cys Ile Asn 
                405                 410                 415     


Val Ile Leu Ala Phe Met Thr Val Ile Leu Val Cys Val Ser Thr Ile 
            420                 425                 430         


Ala Lys Phe Val Ser Pro Met Met Lys Ser Arg Cys His Ile Leu Gly 
        435                 440                 445             


Thr Phe Phe Ala Val Thr Leu Leu Ala Ile Phe Cys Lys Asn Trp Asp 
    450                 455                 460                 


His Ile Leu Cys Ala Ile Glu Arg Met Ile Ile Pro Arg 
465                 470                 475         


<210>  4704
<211>  714
<212>  PRT
<213>  Homo sapiens

<400>  4704

Met Leu Gln Asn Pro Gln Glu Lys Ser Gln Ala Tyr Pro Arg Arg Arg 
1               5                   10                  15      


Arg Pro Gly Cys Tyr Ala Tyr Arg Gln Asn Pro Glu Ala Ile Ala Ala 
            20                  25                  30          


Ala Ala Met Tyr Thr Phe Leu Pro Asp Asn Phe Ser Pro Ala Lys Pro 
        35                  40                  45              


Lys Pro Ser Lys Asp Leu Lys Pro Leu Leu Gly Ser Ala Val Leu Gly 
    50                  55                  60                  


Leu Leu Leu Val Leu Ala Ala Val Val Ala Trp Cys Tyr Tyr Ser Val 
65                  70                  75                  80  


Ser Leu Arg Lys Ala Glu Arg Leu Arg Ala Glu Leu Leu Asp Leu Lys 
                85                  90                  95      


Ala Gly Gly Phe Ser Ile Arg Asn Gln Lys Gly Glu Gln Val Phe Arg 
            100                 105                 110         


Leu Ala Phe Arg Ser Gly Ala Leu Asp Leu Asp Ser Cys Ser Arg Asp 
        115                 120                 125             


Gly Ala Leu Leu Gly Cys Ser Leu Thr Ala Asp Gly Leu Pro Leu His 
    130                 135                 140                 


Phe Phe Ile Gln Thr Val Arg Pro Lys Asp Thr Val Met Cys Tyr Arg 
145                 150                 155                 160 


Val Arg Trp Glu Glu Ala Ala Pro Gly Arg Ala Val Glu His Ala Met 
                165                 170                 175     


Phe Leu Gly Asp Ala Ala Ala His Trp Tyr Gly Gly Ala Glu Met Arg 
            180                 185                 190         


Thr Gln His Trp Pro Ile Arg Leu Asp Gly Gln Gln Glu Pro Gln Pro 
        195                 200                 205             


Phe Val Thr Ser Asp Val Tyr Ser Ser Asp Ala Ala Phe Gly Gly Ile 
    210                 215                 220                 


Leu Glu Arg Tyr Trp Leu Ser Ser Arg Ala Ala Ala Ile Lys Val Asn 
225                 230                 235                 240 


Asp Ser Val Pro Phe His Leu Gly Trp Asn Ser Thr Glu Arg Ser Leu 
                245                 250                 255     


Arg Leu Gln Ala Arg Tyr His Asp Thr Pro Tyr Lys Pro Pro Ala Gly 
            260                 265                 270         


Arg Ala Ala Ala Pro Glu Leu Ser Tyr Arg Val Cys Val Gly Ser Asp 
        275                 280                 285             


Val Thr Ser Ile His Lys Tyr Met Val Arg Arg Tyr Phe Asn Lys Pro 
    290                 295                 300                 


Ser Arg Val Pro Ala Pro Glu Ala Phe Arg Asp Pro Ile Trp Ser Thr 
305                 310                 315                 320 


Trp Ala Leu Tyr Gly Arg Ala Val Asp Gln Asp Lys Val Leu Arg Phe 
                325                 330                 335     


Ala Gln Gln Ile Arg Leu His His Phe Asn Ser Ser His Leu Glu Ile 
            340                 345                 350         


Asp Asp Met Tyr Thr Pro Ala Tyr Gly Asp Phe Asp Phe Asp Glu Val 
        355                 360                 365             


Lys Phe Pro Asn Ala Ser Asp Met Phe Arg Arg Leu Arg Asp Ala Gly 
    370                 375                 380                 


Phe Arg Val Thr Leu Trp Val His Pro Phe Val Asn Tyr Asn Ser Ser 
385                 390                 395                 400 


Arg Phe Gly Glu Gly Val Glu Arg Glu Leu Phe Val Arg Glu Pro Thr 
                405                 410                 415     


Gly Arg Leu Pro Ala Leu Val Arg Trp Trp Asn Gly Ile Gly Ala Val 
            420                 425                 430         


Leu Asp Phe Thr His Pro Lys Ala Arg Asp Trp Phe Gln Gly His Leu 
        435                 440                 445             


Arg Arg Leu Arg Ser Arg Tyr Ser Val Ala Ser Phe Lys Phe Asp Ala 
    450                 455                 460                 


Gly Glu Val Ser Tyr Leu Pro Arg Asp Phe Ser Thr Tyr Arg Pro Leu 
465                 470                 475                 480 


Pro Asp Pro Ser Val Trp Ser Arg Arg Tyr Thr Glu Met Ala Leu Pro 
                485                 490                 495     


Phe Phe Ser Leu Ala Glu Val Arg Val Gly Tyr Gln Ser Gln Asn Ile 
            500                 505                 510         


Ser Cys Phe Phe Arg Leu Val Asp Arg Asp Ser Val Trp Gly Tyr Asp 
        515                 520                 525             


Leu Gly Leu Arg Ser Leu Ile Pro Ala Val Leu Thr Val Ser Met Leu 
    530                 535                 540                 


Gly Tyr Pro Phe Ile Leu Pro Asp Met Val Gly Gly Asn Ala Val Pro 
545                 550                 555                 560 


Gln Arg Thr Ala Gly Gly Asp Val Pro Glu Arg Glu Leu Tyr Ile Arg 
                565                 570                 575     


Trp Leu Glu Val Ala Ala Phe Met Pro Ala Met Gln Phe Ser Ile Pro 
            580                 585                 590         


Pro Trp Arg Tyr Asp Ala Glu Val Val Ala Ile Ala Gln Lys Phe Ala 
        595                 600                 605             


Ala Leu Arg Ala Ser Leu Val Ala Pro Leu Leu Leu Glu Leu Ala Gly 
    610                 615                 620                 


Glu Val Thr Asp Thr Gly Asp Pro Ile Val Arg Pro Leu Trp Trp Ile 
625                 630                 635                 640 


Ala Pro Gly Asp Glu Thr Ala His Arg Ile Asp Ser Gln Phe Leu Ile 
                645                 650                 655     


Gly Asp Thr Leu Leu Val Ala Pro Val Leu Glu Pro Gly Lys Gln Glu 
            660                 665                 670         


Arg Asp Val Tyr Leu Pro Ala Gly Lys Trp Arg Ser Tyr Lys Gly Glu 
        675                 680                 685             


Leu Phe Asp Lys Thr Pro Val Leu Leu Thr Asp Tyr Pro Val Asp Leu 
    690                 695                 700                 


Asp Glu Ile Ala Tyr Phe Thr Trp Ala Ser 
705                 710                 


<210>  4705
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  4705

Met Gly Ile Lys Thr Ala Leu Pro Ala Ala Glu Leu Gly Leu Tyr Ser 
1               5                   10                  15      


Leu Val Leu Ser Gly Ala Leu Ala Tyr Ala Gly Arg Gly Leu Leu Glu 
            20                  25                  30          


Ala Ser Gln Asp Gly Ala His Arg Lys Ala Phe Arg Glu Ser Val Arg 
        35                  40                  45              


Pro Gly Trp Glu Tyr Ile Gly Arg Lys Met Asp Val Ala Asp Phe Glu 
    50                  55                  60                  


Trp Val Met Trp Phe Thr Ser Phe Arg Asn Val Ile Ile Phe Ala Leu 
65                  70                  75                  80  


Ser Gly His Val Leu Phe Ala Lys Leu Cys Thr Met Val Ala Pro Lys 
                85                  90                  95      


Leu Arg Ser Trp Met Tyr Ala Val Tyr Gly Ala Leu Ala Val Met Gly 
            100                 105                 110         


Thr Met Gly Pro Trp Tyr Leu Leu Leu Leu Leu Gly His Cys Val Gly 
        115                 120                 125             


Leu Tyr Val Ala Ser Leu Leu Gly Gln Pro Trp Leu Cys Leu Gly Leu 
    130                 135                 140                 


Gly Leu Ala Ser Leu Ala Ser Phe Lys Met Asp Pro Leu Ile Ser Trp 
145                 150                 155                 160 


Gln Ser Gly Phe Val Thr Gly Thr Phe Asp Leu Gln Glu Val Leu Phe 
                165                 170                 175     


His Gly Gly Ser Ser Phe Thr Val Leu Arg Cys Thr Ser Phe Ala Leu 
            180                 185                 190         


Glu Ser Cys Ala His Pro Asp Arg His Tyr Ser Leu Ala Asp Leu Leu 
        195                 200                 205             


Lys Tyr Asn Phe Tyr Leu Pro Phe Phe Phe Phe Gly Pro Ile Met Thr 
    210                 215                 220                 


Phe Asp Arg Phe His Ala Gln Val Ser Gln Val Glu Pro Val Arg Arg 
225                 230                 235                 240 


Glu Gly Glu Leu Trp His Ile Arg Ala Gln Ala Gly Leu Ser Val Val 
                245                 250                 255     


Ala Ile Met Ala Val Asp Ile Phe Phe His Phe Phe Tyr Ile Leu Thr 
            260                 265                 270         


Ile Pro Ser Asp Leu Lys Phe Ala Asn Arg Leu Pro Asp Ser Ala Leu 
        275                 280                 285             


Ala Gly Leu Ala Tyr Ser Asn Leu Val Tyr Asp Trp Val Lys Ala Ala 
    290                 295                 300                 


Val Leu Phe Gly Val Val Asn Thr Val Ala Cys Leu Asp His Leu Asp 
305                 310                 315                 320 


Pro Pro Gln Pro Pro Lys Cys Ile Thr Ala Leu Tyr Val Phe Ala Glu 
                325                 330                 335     


Thr His Phe Asp Arg Gly Ile Asn Asp Trp Leu Cys Lys Tyr Val Tyr 
            340                 345                 350         


Asn His Ile Gly Gly Glu His Ser Ala Val Ile Pro Glu Leu Ala Ala 
        355                 360                 365             


Thr Val Ala Thr Phe Ala Ile Thr Thr Leu Trp Leu Gly Pro Cys Asp 
    370                 375                 380                 


Ile Val Tyr Leu Trp Ser Phe Leu Asn Cys Phe Gly Leu Asn Phe Glu 
385                 390                 395                 400 


Leu Trp Met Gln Lys Leu Ala Glu Trp Gly Pro Leu Ala Arg Ile Glu 
                405                 410                 415     


Ala Ser Leu Ser Val Gln Met Ser Arg Arg Val Arg Ala Leu Phe Gly 
            420                 425                 430         


Ala Met Asn Phe Trp Ala Ile Ile Met Tyr Asn Leu Val Ser Leu Asn 
        435                 440                 445             


Ser Leu Lys Phe Thr Glu Leu Val Ala Arg Arg Leu Leu Leu Thr Gly 
    450                 455                 460                 


Phe Pro Gln Thr Thr Leu Ser Ile Leu Phe Val Thr Tyr Cys Gly Val 
465                 470                 475                 480 


Gln Leu Val Lys Glu Arg Glu Arg Thr Leu Ala Leu Glu Glu Glu Gln 
                485                 490                 495     


Lys Gln Asp Lys Glu Lys Pro Glu 
            500                 


<210>  4706
<211>  1116
<212>  PRT
<213>  Homo sapiens

<400>  4706

Met Leu Asn Asn Leu Thr Asp Cys Glu Asp Gly Asp Gly Gly Ala Asn 
1               5                   10                  15      


Pro Gly Asp Gly Asn Pro Lys Glu Ser Ser Pro Phe Ile Asn Ser Thr 
            20                  25                  30          


Asp Thr Glu Lys Gly Lys Glu Tyr Asp Gly Lys Asn Met Ala Leu Phe 
        35                  40                  45              


Glu Glu Glu Met Asp Thr Ser Pro Met Val Ser Ser Leu Leu Ser Gly 
    50                  55                  60                  


Leu Ala Asn Tyr Thr Asn Leu Pro Gln Gly Ser Arg Glu His Glu Glu 
65                  70                  75                  80  


Ala Glu Asn Asn Glu Gly Gly Lys Lys Lys Pro Val Gln Ala Pro Arg 
                85                  90                  95      


Met Gly Thr Phe Met Gly Val Tyr Leu Pro Cys Leu Gln Asn Ile Phe 
            100                 105                 110         


Gly Val Ile Leu Phe Leu Arg Leu Thr Trp Val Val Gly Ile Ala Gly 
        115                 120                 125             


Ile Met Glu Ser Phe Cys Met Val Phe Ile Cys Cys Ser Cys Thr Met 
    130                 135                 140                 


Leu Thr Ala Ile Ser Met Ser Ala Ile Ala Thr Asn Gly Val Val Pro 
145                 150                 155                 160 


Ala Gly Gly Ser Tyr Tyr Met Ile Ser Arg Ser Leu Gly Pro Glu Phe 
                165                 170                 175     


Gly Gly Ala Val Gly Leu Cys Phe Tyr Leu Gly Thr Thr Phe Ala Gly 
            180                 185                 190         


Ala Met Tyr Ile Leu Gly Thr Ile Glu Ile Leu Leu Ala Tyr Leu Phe 
        195                 200                 205             


Pro Ala Met Ala Ile Phe Lys Ala Glu Asp Ala Ser Gly Glu Ala Ala 
    210                 215                 220                 


Ala Met Leu Asn Asn Met Arg Val Tyr Gly Thr Cys Val Leu Thr Cys 
225                 230                 235                 240 


Met Ala Thr Val Val Phe Val Gly Val Lys Tyr Val Asn Lys Phe Ala 
                245                 250                 255     


Leu Val Phe Leu Gly Cys Val Ile Leu Ser Ile Leu Ala Ile Tyr Ala 
            260                 265                 270         


Gly Val Ile Lys Ser Ala Phe Asp Pro Pro Asn Phe Pro Ile Cys Leu 
        275                 280                 285             


Leu Gly Asn Arg Thr Leu Ser Arg His Gly Phe Asp Val Cys Ala Lys 
    290                 295                 300                 


Leu Ala Trp Glu Gly Asn Glu Thr Val Thr Thr Arg Leu Trp Gly Leu 
305                 310                 315                 320 


Phe Cys Ser Ser Arg Phe Leu Asn Ala Thr Cys Asp Glu Tyr Phe Thr 
                325                 330                 335     


Arg Asn Asn Val Thr Glu Ile Gln Gly Ile Pro Gly Ala Ala Ser Gly 
            340                 345                 350         


Leu Ile Lys Glu Asn Leu Trp Ser Ser Tyr Leu Thr Lys Gly Val Ile 
        355                 360                 365             


Val Glu Arg Ser Gly Met Thr Ser Val Gly Leu Ala Asp Gly Thr Pro 
    370                 375                 380                 


Ile Asp Met Asp His Pro Tyr Val Phe Ser Asp Met Thr Ser Tyr Phe 
385                 390                 395                 400 


Thr Leu Leu Val Gly Ile Tyr Phe Pro Ser Val Thr Gly Ile Met Ala 
                405                 410                 415     


Gly Ser Asn Arg Ser Gly Asp Leu Arg Asp Ala Gln Lys Ser Ile Pro 
            420                 425                 430         


Thr Gly Thr Ile Leu Ala Ile Ala Thr Thr Ser Ala Val Tyr Ile Ser 
        435                 440                 445             


Ser Val Val Leu Phe Gly Ala Cys Ile Glu Gly Val Val Leu Arg Asp 
    450                 455                 460                 


Lys Phe Gly Glu Ala Val Asn Gly Asn Leu Val Val Gly Thr Leu Ala 
465                 470                 475                 480 


Trp Pro Ser Pro Trp Val Ile Val Ile Gly Ser Phe Phe Ser Thr Cys 
                485                 490                 495     


Gly Ala Gly Leu Gln Ser Leu Thr Gly Ala Pro Arg Leu Leu Gln Ala 
            500                 505                 510         


Ile Ser Arg Asp Gly Ile Val Pro Phe Leu Gln Val Phe Gly His Gly 
        515                 520                 525             


Lys Ala Asn Gly Glu Pro Thr Trp Ala Leu Leu Leu Thr Ala Cys Ile 
    530                 535                 540                 


Cys Glu Ile Gly Ile Leu Ile Ala Ser Leu Asp Glu Val Ala Pro Ile 
545                 550                 555                 560 


Leu Ser Met Phe Phe Leu Met Cys Tyr Met Phe Val Asn Leu Ala Cys 
                565                 570                 575     


Ala Val Gln Thr Leu Leu Arg Thr Pro Asn Trp Arg Pro Arg Phe Arg 
            580                 585                 590         


Tyr Tyr His Trp Thr Leu Ser Phe Leu Gly Met Ser Leu Cys Leu Ala 
        595                 600                 605             


Leu Met Phe Ile Cys Ser Trp Tyr Tyr Ala Leu Val Ala Met Leu Ile 
    610                 615                 620                 


Ala Gly Leu Ile Tyr Lys Tyr Ile Glu Tyr Arg Gly Ala Glu Lys Glu 
625                 630                 635                 640 


Trp Gly Asp Gly Ile Arg Gly Leu Ser Leu Ser Ala Ala Arg Tyr Ala 
                645                 650                 655     


Leu Leu Arg Leu Glu Glu Gly Pro Pro His Thr Lys Asn Trp Arg Pro 
            660                 665                 670         


Gln Leu Leu Val Leu Val Arg Val Asp Gln Asp Gln Asn Val Val His 
        675                 680                 685             


Pro Gln Leu Leu Ser Leu Thr Ser Gln Leu Lys Ala Gly Lys Gly Leu 
    690                 695                 700                 


Thr Ile Val Gly Ser Val Leu Glu Gly Thr Phe Leu Glu Asn His Pro 
705                 710                 715                 720 


Gln Ala Gln Arg Ala Glu Glu Ser Ile Arg Arg Leu Met Glu Ala Glu 
                725                 730                 735     


Lys Val Lys Gly Phe Cys Gln Val Val Ile Ser Ser Asn Leu Arg Asp 
            740                 745                 750         


Gly Val Ser His Leu Ile Gln Ser Gly Gly Leu Gly Gly Leu Gln His 
        755                 760                 765             


Asn Thr Val Leu Val Gly Trp Pro Arg Asn Trp Arg Gln Lys Glu Asp 
    770                 775                 780                 


His Gln Thr Trp Arg Asn Phe Ile Glu Leu Val Arg Glu Thr Thr Ala 
785                 790                 795                 800 


Gly His Leu Ala Leu Leu Val Thr Lys Asn Val Ser Met Phe Pro Gly 
                805                 810                 815     


Asn Pro Glu Arg Phe Ser Glu Gly Ser Ile Asp Val Trp Trp Ile Val 
            820                 825                 830         


His Asp Gly Gly Met Leu Met Leu Leu Pro Phe Leu Leu Arg His His 
        835                 840                 845             


Lys Val Trp Arg Lys Cys Lys Met Arg Ile Phe Thr Val Ala Gln Met 
    850                 855                 860                 


Asp Asp Asn Ser Ile Gln Met Lys Lys Asp Leu Thr Thr Phe Leu Tyr 
865                 870                 875                 880 


His Leu Arg Ile Thr Ala Glu Val Glu Val Val Glu Met His Glu Ser 
                885                 890                 895     


Asp Ile Ser Ala Tyr Thr Tyr Glu Lys Thr Leu Val Met Glu Gln Arg 
            900                 905                 910         


Ser Gln Ile Leu Lys Gln Met His Leu Thr Lys Asn Glu Arg Glu Arg 
        915                 920                 925             


Glu Ile Gln Ser Ile Thr Asp Glu Ser Arg Gly Ser Ile Arg Arg Lys 
    930                 935                 940                 


Asn Pro Ala Asn Thr Arg Leu Arg Leu Asn Val Pro Glu Glu Thr Ala 
945                 950                 955                 960 


Gly Asp Ser Glu Glu Lys Pro Glu Glu Glu Val Gln Leu Ile His Asp 
                965                 970                 975     


Gln Ser Ala Pro Ser Cys Pro Ser Ser Ser Pro Ser Pro Gly Glu Glu 
            980                 985                 990         


Pro Glu Gly Glu Gly Glu Thr Asp  Pro Glu Lys Val His  Leu Thr Trp 
        995                 1000                 1005             


Thr Lys  Asp Lys Ser Val Ala  Glu Lys Asn Lys Gly  Pro Ser Pro 
    1010                 1015                 1020             


Val Ser  Ser Glu Gly Ile Lys  Asp Phe Phe Ser Met  Lys Pro Glu 
    1025                 1030                 1035             


Trp Glu  Asn Leu Asn Gln Ser  Asn Val Arg Arg Met  His Thr Ala 
    1040                 1045                 1050             


Val Arg  Leu Asn Glu Val Ile  Val Lys Lys Ser Arg  Asp Ala Lys 
    1055                 1060                 1065             


Leu Val  Leu Leu Asn Met Pro  Gly Pro Pro Arg Asn  Arg Asn Gly 
    1070                 1075                 1080             


Asp Glu  Asn Tyr Met Glu Phe  Leu Glu Val Leu Thr  Glu His Leu 
    1085                 1090                 1095             


Asp Arg  Val Met Leu Val Arg  Gly Gly Gly Arg Glu  Val Ile Thr 
    1100                 1105                 1110             


Ile Tyr  Ser 
    1115     


<210>  4707
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  4707

Met Lys Gly Phe Lys Leu Ser Cys Thr Ala Ser Asn Ser Asn Arg Ser 
1               5                   10                  15      


Thr Pro Ala Cys Ser Pro Ile Leu Arg Lys Arg Ser Arg Ser Pro Thr 
            20                  25                  30          


Pro Gln Asn Gln Asp Gly Asp Thr Met Val Glu Lys Gly Ser Asp His 
        35                  40                  45              


Ser Ser Asp Lys Ser Pro Ser Thr Pro Glu Gln Gly Val Gln Arg Ser 
    50                  55                  60                  


Cys Ser Ser Gln Ser Gly Arg Ser Gly Gly Lys Asn Ser Lys Lys Ser 
65                  70                  75                  80  


Gln Ser Trp Tyr Asn Val Leu Ser Pro Thr Tyr Lys Gln Arg Asn Glu 
                85                  90                  95      


Asp Phe Arg Lys Leu Phe Lys Gln Leu Pro Asp Thr Glu Arg Leu Ile 
            100                 105                 110         


Val Asp Tyr Ser Cys Ala Leu Gln Arg Asp Ile Leu Leu Gln Gly Arg 
        115                 120                 125             


Leu Tyr Leu Ser Glu Asn Trp Ile Cys Phe Tyr Ser Asn Ile Phe Arg 
    130                 135                 140                 


Trp Glu Thr Leu Leu Thr Val Arg Leu Lys Asp Ile Cys Ser Met Thr 
145                 150                 155                 160 


Lys Glu Lys Thr Ala Arg Leu Ile Pro Asn Ala Ile Gln Val Cys Thr 
                165                 170                 175     


Asp Ser Glu Lys His Phe Phe Thr Ser Phe Gly Ala Arg Asp Arg Thr 
            180                 185                 190         


Tyr Met Met Met Phe Arg Leu Trp Gln Asn Ala Leu Leu Glu Lys Pro 
        195                 200                 205             


Leu Cys Pro Lys Glu Leu Trp His Phe Val His Gln Cys Tyr Gly Asn 
    210                 215                 220                 


Glu Leu Gly Leu Thr Ser Asp Asp Glu Asp Tyr Val Pro Pro Asp Asp 
225                 230                 235                 240 


Asp Phe Asn Thr Met Gly Tyr Cys Glu Glu Ile Pro Val Glu Glu Asn 
                245                 250                 255     


Glu Val Asn Asp Ser Ser Ser Lys Ser Ser Ile Glu Thr Lys Pro Asp 
            260                 265                 270         


Ala Ser Pro Gln Leu Pro Lys Lys Ser Ile Thr Asn Ser Thr Leu Thr 
        275                 280                 285             


Ser Thr Gly Ser Ser Glu Ala Pro Val Ser Phe Asp Gly Leu Pro Leu 
    290                 295                 300                 


Glu Glu Glu Ala Leu Glu Gly Asp Gly Ser Leu Glu Lys Glu Leu Ala 
305                 310                 315                 320 


Ile Asp Asn Ile Met Gly Glu Lys Ile Glu Met Ile Ala Pro Val Asn 
                325                 330                 335     


Ser Pro Ser Leu Asp Phe Asn Asp Asn Glu Asp Ile Pro Thr Glu Leu 
            340                 345                 350         


Ser Asp Ser Ser Asp Thr His Asp Glu Gly Glu Val Gln Ala Phe Tyr 
        355                 360                 365             


Glu Asp Leu Ser Gly Arg Gln Tyr Val Asn Glu Val Phe Asn Phe Ser 
    370                 375                 380                 


Val Asp Lys Leu Tyr Asp Leu Leu Phe Thr Asn Ser Pro Phe Gln Arg 
385                 390                 395                 400 


Asp Phe Met Glu Gln Arg Arg Phe Ser Asp Ile Ile Phe His Pro Trp 
                405                 410                 415     


Lys Lys Glu Glu Asn Gly Asn Gln Ser Arg Val Ile Leu Tyr Thr Ile 
            420                 425                 430         


Thr Leu Thr Asn Pro Leu Ala Pro Lys Thr Ala Thr Val Arg Glu Thr 
        435                 440                 445             


Gln Thr Met Tyr Lys Ala Ser Gln Glu Ser Glu Cys Tyr Val Ile Asp 
    450                 455                 460                 


Ala Glu Val Leu Thr His Asp Val Pro Tyr His Asp Tyr Phe Tyr Thr 
465                 470                 475                 480 


Ile Asn Arg Tyr Thr Leu Thr Arg Val Ala Arg Asn Lys Ser Arg Leu 
                485                 490                 495     


Arg Val Ser Thr Glu Leu Arg Tyr Arg Lys Gln Pro Trp Gly Leu Val 
            500                 505                 510         


Lys Thr Phe Ile Glu Lys Asn Phe Trp Ser Gly Leu Glu Asp Tyr Phe 
        515                 520                 525             


Arg His Leu Glu Ser Glu Leu Ala Lys Thr Glu Ser Thr Tyr Leu Ala 
    530                 535                 540                 


Glu Met His Arg Gln Ser Pro Lys Glu Lys Ala Ser Lys Thr Thr Thr 
545                 550                 555                 560 


Val Arg Arg Arg Lys Arg Pro His Ala His Leu Arg Val Pro His Leu 
                565                 570                 575     


Glu Glu Val Met Ser Pro Val Thr Thr Pro Thr Asp Glu Asp Val Gly 
            580                 585                 590         


His Arg Ile Lys His Val Ala Gly Ser Thr Gln Thr Arg His Ile Pro 
        595                 600                 605             


Glu Asp Thr Pro Asn Gly Phe His Leu Gln Ser Val Ser Lys Leu Leu 
    610                 615                 620                 


Leu Val Ile Ser Cys Val Ile Cys Phe Ser Leu Val Leu Leu Val Ile 
625                 630                 635                 640 


Leu Asn Met Met Leu Phe Tyr Lys Leu Trp Met Leu Glu Tyr Thr Thr 
                645                 650                 655     


Gln Thr Leu Thr Ala Trp Gln Gly Leu Arg Leu Gln Glu Arg Leu Pro 
            660                 665                 670         


Gln Ser Gln Thr Glu Trp Ala Gln Leu Leu Glu Ser Gln Gln Lys Tyr 
        675                 680                 685             


His Asp Thr Glu Leu Gln Lys Trp Arg Glu Ile Ile Lys Ser Ser Val 
    690                 695                 700                 


Met Leu Leu Asp Gln Met Lys Asp Ser Leu Ile Asn Leu Gln Asn Gly 
705                 710                 715                 720 


Ile Arg Ser Arg Asp Tyr Thr Ser Glu Ser Glu Glu Lys Arg Asn Arg 
                725                 730                 735     


Tyr His 
        


<210>  4708
<211>  438
<212>  PRT
<213>  Homo sapiens

<400>  4708

Met Ala Met Ser Leu Ile Gln Ala Cys Cys Ser Leu Ala Leu Ser Thr 
1               5                   10                  15      


Trp Leu Leu Ser Phe Cys Phe Val His Leu Leu Cys Leu Asp Phe Thr 
            20                  25                  30          


Val Ala Glu Lys Glu Glu Trp Tyr Thr Ala Phe Val Asn Ile Thr Tyr 
        35                  40                  45              


Ala Glu Pro Ala Pro Asp Pro Gly Ala Gly Ala Ala Gly Gly Gly Gly 
    50                  55                  60                  


Ala Glu Leu His Thr Glu Lys Thr Glu Cys Gly Arg Tyr Gly Glu His 
65                  70                  75                  80  


Ser Pro Lys Gln Asp Ala Arg Gly Glu Val Val Met Ala Ser Ser Ala 
                85                  90                  95      


His Asp Arg Leu Ala Cys Asp Pro Asn Thr Lys Phe Ala Ala Pro Thr 
            100                 105                 110         


Arg Gly Lys Asn Trp Ile Ala Leu Ile Pro Lys Gly Asn Cys Thr Tyr 
        115                 120                 125             


Arg Asp Lys Ile Arg Asn Ala Phe Leu Gln Asn Ala Ser Ala Val Val 
    130                 135                 140                 


Ile Phe Asn Val Gly Ser Asn Thr Asn Glu Thr Ile Thr Met Pro His 
145                 150                 155                 160 


Ala Gly Val Glu Asp Ile Val Ala Ile Met Ile Pro Glu Pro Lys Gly 
                165                 170                 175     


Lys Glu Ile Val Ser Leu Leu Glu Arg Asn Ile Thr Val Thr Met Tyr 
            180                 185                 190         


Ile Thr Ile Gly Thr Arg Asn Leu Gln Lys Tyr Val Ser Arg Thr Ser 
        195                 200                 205             


Val Val Phe Val Ser Ile Ser Phe Ile Val Leu Met Ile Ile Ser Leu 
    210                 215                 220                 


Ala Trp Leu Val Phe Tyr Tyr Ile Gln Arg Phe Arg Tyr Ala Asn Ala 
225                 230                 235                 240 


Arg Asp Arg Asn Gln Arg Arg Leu Gly Asp Ala Ala Lys Lys Ala Ile 
                245                 250                 255     


Ser Lys Leu Gln Ile Arg Thr Ile Lys Lys Gly Asp Lys Glu Thr Glu 
            260                 265                 270         


Ser Asp Phe Asp Asn Cys Ala Val Cys Ile Glu Gly Tyr Lys Pro Asn 
        275                 280                 285             


Asp Val Val Arg Ile Leu Pro Cys Arg His Leu Phe His Lys Ser Cys 
    290                 295                 300                 


Val Asp Pro Trp Leu Leu Asp His Arg Thr Cys Pro Met Cys Lys Met 
305                 310                 315                 320 


Asn Ile Leu Lys Ala Leu Gly Ile Pro Pro Asn Ala Asp Cys Met Asp 
                325                 330                 335     


Asp Leu Pro Thr Asp Phe Glu Gly Ser Leu Gly Gly Pro Pro Thr Asn 
            340                 345                 350         


Gln Ile Thr Gly Ala Ser Asp Thr Thr Val Asn Glu Ser Ser Val Thr 
        355                 360                 365             


Leu Asp Pro Ala Val Arg Thr Val Gly Ala Leu Gln Val Val Gln Asp 
    370                 375                 380                 


Thr Asp Pro Ile Pro Gln Glu Gly Asp Val Ile Phe Thr Thr Asn Ser 
385                 390                 395                 400 


Glu Gln Glu Pro Ala Val Ser Ser Asp Ser Asp Ile Ser Leu Ile Met 
                405                 410                 415     


Ala Met Glu Val Gly Leu Ser Asp Val Glu Leu Ser Thr Asp Gln Asp 
            420                 425                 430         


Cys Glu Glu Val Lys Ser 
        435             


<210>  4709
<211>  893
<212>  PRT
<213>  Homo sapiens

<400>  4709

Met Thr Pro Pro Ser Arg Ala Glu Ala Gly Val Arg Arg Ser Arg Val 
1               5                   10                  15      


Pro Ser Glu Gly Arg Trp Arg Gly Ala Glu Pro Pro Gly Ile Ser Ala 
            20                  25                  30          


Ser Thr Gln Pro Ala Ser Ala Gly Arg Ala Ala Arg His Cys Gly Ala 
        35                  40                  45              


Met Ser Gly Ala Arg Gly Glu Gly Pro Glu Ala Gly Ala Gly Gly Ala 
    50                  55                  60                  


Gly Gly Arg Ala Ala Pro Glu Asn Pro Gly Gly Val Leu Ser Val Glu 
65                  70                  75                  80  


Leu Pro Gly Leu Leu Ala Gln Leu Ala Arg Ser Phe Ala Leu Leu Leu 
                85                  90                  95      


Pro Val Tyr Ala Leu Gly Tyr Leu Gly Leu Ser Phe Ser Trp Val Leu 
            100                 105                 110         


Leu Ala Leu Ala Leu Leu Ala Trp Cys Arg Arg Ser Arg Gly Leu Lys 
        115                 120                 125             


Ala Leu Arg Leu Cys Arg Ala Leu Ala Leu Leu Glu Asp Glu Glu Arg 
    130                 135                 140                 


Val Val Arg Leu Gly Val Arg Ala Cys Asp Leu Pro Ala Trp Val His 
145                 150                 155                 160 


Phe Pro Asp Thr Glu Arg Ala Glu Trp Leu Asn Lys Thr Val Lys His 
                165                 170                 175     


Met Trp Pro Phe Ile Cys Gln Phe Ile Glu Lys Leu Phe Arg Glu Thr 
            180                 185                 190         


Ile Glu Pro Ala Val Arg Gly Ala Asn Thr His Leu Ser Thr Phe Ser 
        195                 200                 205             


Phe Thr Lys Val Asp Val Gly Gln Gln Pro Leu Arg Ile Asn Gly Val 
    210                 215                 220                 


Lys Val Tyr Thr Glu Asn Val Asp Lys Arg Gln Ile Ile Leu Asp Leu 
225                 230                 235                 240 


Gln Ile Ser Phe Val Gly Asn Cys Glu Ile Asp Leu Glu Ile Lys Arg 
                245                 250                 255     


Tyr Phe Cys Arg Ala Gly Val Lys Ser Ile Gln Ile His Gly Thr Met 
            260                 265                 270         


Arg Val Ile Leu Glu Pro Leu Ile Gly Asp Met Pro Leu Val Gly Ala 
        275                 280                 285             


Leu Ser Ile Phe Phe Leu Arg Lys Pro Leu Leu Glu Ile Asn Trp Thr 
    290                 295                 300                 


Gly Leu Thr Asn Leu Leu Asp Val Pro Gly Leu Asn Gly Leu Ser Asp 
305                 310                 315                 320 


Thr Ile Ile Leu Asp Ile Ile Ser Asn Tyr Leu Val Leu Pro Asn Arg 
                325                 330                 335     


Ile Thr Val Pro Leu Val Ser Glu Val Gln Ile Ala Gln Leu Arg Phe 
            340                 345                 350         


Pro Val Pro Lys Gly Val Leu Arg Ile His Phe Ile Glu Ala Gln Asp 
        355                 360                 365             


Leu Gln Gly Lys Asp Thr Tyr Leu Lys Gly Leu Val Lys Gly Lys Ser 
    370                 375                 380                 


Asp Pro Tyr Gly Ile Ile Arg Val Gly Asn Gln Ile Phe Gln Ser Arg 
385                 390                 395                 400 


Val Ile Lys Glu Asn Leu Ser Pro Lys Trp Asn Glu Val Tyr Glu Ala 
                405                 410                 415     


Leu Val Tyr Glu His Pro Gly Gln Glu Leu Glu Ile Glu Leu Phe Asp 
            420                 425                 430         


Glu Asp Pro Asp Lys Asp Asp Phe Leu Gly Ser Leu Met Ile Asp Leu 
        435                 440                 445             


Ile Glu Val Glu Lys Glu Arg Leu Leu Asp Glu Trp Phe Thr Leu Asp 
    450                 455                 460                 


Glu Val Pro Lys Gly Lys Leu His Leu Arg Leu Glu Trp Leu Thr Leu 
465                 470                 475                 480 


Met Pro Asn Ala Ser Asn Leu Asp Lys Val Leu Thr Asp Ile Lys Ala 
                485                 490                 495     


Asp Lys Asp Gln Ala Asn Asp Gly Leu Ser Ser Ala Leu Leu Ile Leu 
            500                 505                 510         


Tyr Leu Asp Ser Ala Arg Asn Leu Pro Ser Gly Lys Lys Ile Ser Ser 
        515                 520                 525             


Asn Pro Asn Pro Val Val Gln Met Ser Val Gly His Lys Ala Gln Glu 
    530                 535                 540                 


Ser Lys Ile Arg Tyr Lys Thr Asn Glu Pro Val Trp Glu Glu Asn Phe 
545                 550                 555                 560 


Thr Phe Phe Ile His Asn Pro Lys Arg Gln Asp Leu Glu Val Glu Val 
                565                 570                 575     


Arg Asp Glu Gln His Gln Cys Ser Leu Gly Asn Leu Lys Val Pro Leu 
            580                 585                 590         


Ser Gln Leu Leu Thr Ser Glu Asp Met Thr Val Ser Gln Arg Phe Gln 
        595                 600                 605             


Leu Ser Asn Ser Gly Pro Asn Ser Thr Ile Lys Met Lys Ile Ala Leu 
    610                 615                 620                 


Arg Val Leu His Leu Glu Lys Arg Glu Arg Pro Pro Asp His Gln His 
625                 630                 635                 640 


Ser Ala Gln Val Lys Arg Pro Ser Val Ser Lys Glu Gly Arg Lys Thr 
                645                 650                 655     


Ser Ile Lys Ser His Met Ser Gly Ser Pro Gly Pro Gly Gly Ser Asn 
            660                 665                 670         


Thr Ala Pro Ser Thr Pro Val Ile Gly Gly Ser Asp Lys Pro Gly Met 
        675                 680                 685             


Glu Glu Lys Ala Gln Pro Pro Glu Ala Gly Pro Gln Gly Leu His Asp 
    690                 695                 700                 


Leu Gly Arg Ser Ser Ser Ser Leu Leu Ala Ser Pro Gly His Ile Ser 
705                 710                 715                 720 


Val Lys Glu Pro Thr Pro Ser Ile Ala Ser Asp Ile Ser Leu Pro Ile 
                725                 730                 735     


Ala Thr Gln Glu Leu Arg Gln Arg Leu Arg Gln Leu Glu Asn Gly Thr 
            740                 745                 750         


Thr Leu Gly Gln Ser Pro Leu Gly Gln Ile Gln Leu Thr Ile Arg His 
        755                 760                 765             


Ser Ser Gln Arg Asn Lys Leu Ile Val Val Val His Ala Cys Arg Asn 
    770                 775                 780                 


Leu Ile Ala Phe Ser Glu Asp Gly Ser Asp Pro Tyr Val Arg Met Tyr 
785                 790                 795                 800 


Leu Leu Pro Asp Lys Arg Arg Ser Gly Arg Arg Lys Thr His Val Ser 
                805                 810                 815     


Lys Lys Thr Leu Asn Pro Val Phe Asp Gln Ser Phe Asp Phe Ser Val 
            820                 825                 830         


Ser Leu Pro Glu Val Gln Arg Arg Thr Leu Asp Val Ala Val Lys Asn 
        835                 840                 845             


Ser Gly Gly Phe Leu Ser Lys Asp Lys Gly Leu Leu Gly Lys Val Leu 
    850                 855                 860                 


Val Ala Leu Ala Ser Glu Glu Leu Ala Lys Gly Trp Thr Gln Trp Tyr 
865                 870                 875                 880 


Asp Leu Thr Glu Asp Gly Thr Arg Pro Gln Ala Met Thr 
                885                 890             


<210>  4710
<211>  1381
<212>  PRT
<213>  Homo sapiens

<400>  4710

Met Ala Ser Pro Arg Ala Ser Arg Trp Pro Pro Pro Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Pro Leu Leu Leu Leu Pro Pro Ala Ala Pro Gly Thr Arg Asp 
            20                  25                  30          


Pro Pro Pro Ser Pro Ala Arg Arg Ala Leu Ser Leu Ala Pro Leu Ala 
        35                  40                  45              


Gly Ala Gly Leu Glu Leu Gln Leu Glu Arg Arg Pro Glu Arg Glu Pro 
    50                  55                  60                  


Pro Pro Thr Pro Pro Arg Glu Arg Arg Gly Pro Ala Thr Pro Gly Pro 
65                  70                  75                  80  


Ser Tyr Arg Ala Pro Glu Pro Gly Ala Ala Thr Gln Arg Gly Pro Ser 
                85                  90                  95      


Gly Arg Ala Pro Arg Gly Gly Ser Ala Asp Ala Ala Trp Lys His Trp 
            100                 105                 110         


Pro Glu Ser Asn Thr Glu Ala His Val Glu Asn Ile Thr Phe Tyr Gln 
        115                 120                 125             


Asn Gln Glu Asp Phe Ser Thr Val Ser Ser Lys Glu Gly Val Met Val 
    130                 135                 140                 


Gln Thr Ser Gly Lys Ser His Ala Ala Ser Asp Ala Pro Glu Asn Leu 
145                 150                 155                 160 


Thr Leu Leu Ala Glu Thr Ala Asp Ala Arg Gly Arg Ser Gly Ser Ser 
                165                 170                 175     


Ser Arg Thr Asn Phe Thr Ile Leu Pro Val Gly Tyr Ser Leu Glu Ile 
            180                 185                 190         


Ala Thr Ala Leu Thr Ser Gln Ser Gly Asn Leu Ala Ser Glu Ser Leu 
        195                 200                 205             


His Leu Pro Ser Ser Ser Ser Glu Phe Asp Glu Arg Ile Ala Ala Phe 
    210                 215                 220                 


Gln Thr Lys Ser Gly Thr Ala Ser Glu Met Gly Thr Glu Arg Ala Met 
225                 230                 235                 240 


Gly Leu Ser Glu Glu Trp Thr Val His Ser Gln Glu Ala Thr Thr Ser 
                245                 250                 255     


Ala Trp Ser Pro Ser Phe Leu Pro Ala Leu Glu Met Gly Glu Leu Thr 
            260                 265                 270         


Thr Pro Ser Arg Lys Arg Asn Ser Ser Gly Pro Asp Leu Ser Trp Leu 
        275                 280                 285             


His Phe Tyr Arg Thr Ala Ala Ser Ser Pro Leu Leu Asp Leu Ser Ser 
    290                 295                 300                 


Ser Ser Glu Ser Thr Glu Lys Leu Asn Asn Ser Thr Gly Leu Gln Ser 
305                 310                 315                 320 


Ser Ser Val Ser Gln Thr Lys Thr Met His Val Ala Thr Val Phe Thr 
                325                 330                 335     


Asp Gly Gly Pro Arg Thr Leu Arg Ser Leu Thr Val Ser Leu Gly Pro 
            340                 345                 350         


Val Ser Lys Thr Glu Gly Phe Pro Lys Asp Ser Arg Ile Ala Thr Thr 
        355                 360                 365             


Ser Ser Ser Val Leu Leu Ser Pro Ser Ala Val Glu Ser Arg Arg Asn 
    370                 375                 380                 


Ser Arg Val Thr Gly Asn Pro Gly Asp Glu Glu Phe Ile Glu Pro Ser 
385                 390                 395                 400 


Thr Glu Asn Glu Phe Gly Leu Thr Ser Leu Arg Trp Gln Asn Asp Ser 
                405                 410                 415     


Pro Thr Phe Gly Glu His Gln Leu Ala Ser Ser Ser Glu Val Gln Asn 
            420                 425                 430         


Gly Ser Pro Met Ser Gln Thr Glu Thr Val Ser Arg Ser Val Ala Pro 
        435                 440                 445             


Met Arg Gly Gly Glu Ile Thr Ala His Trp Leu Leu Thr Asn Ser Thr 
    450                 455                 460                 


Thr Ser Ala Asp Val Thr Gly Ser Ser Ala Ser Tyr Pro Glu Gly Val 
465                 470                 475                 480 


Asn Ala Ser Val Leu Thr Gln Phe Ser Asp Ser Thr Val Gln Ser Gly 
                485                 490                 495     


Gly Ser His Thr Ala Leu Gly Asp Arg Ser Tyr Ser Glu Ser Ser Ser 
            500                 505                 510         


Thr Ser Ser Ser Glu Ser Leu Asn Ser Ser Ala Pro Arg Gly Glu Arg 
        515                 520                 525             


Ser Ile Ala Gly Ile Ser Tyr Gly Gln Val Arg Gly Thr Ala Ile Glu 
    530                 535                 540                 


Gln Arg Thr Ser Ser Asp His Thr Asp His Thr Tyr Leu Ser Ser Thr 
545                 550                 555                 560 


Phe Thr Lys Gly Glu Arg Ala Leu Leu Ser Ile Thr Asp Asn Ser Ser 
                565                 570                 575     


Ser Ser Asp Ile Val Glu Ser Ser Thr Ser Tyr Ile Lys Ile Ser Asn 
            580                 585                 590         


Ser Ser His Ser Glu Tyr Ser Ser Phe Phe His Ala Gln Thr Glu Arg 
        595                 600                 605             


Ser Asn Ile Ser Ser Tyr Asp Gly Glu Tyr Ala Gln Pro Ser Thr Glu 
    610                 615                 620                 


Ser Pro Val Leu His Thr Ser Asn Leu Pro Ser Tyr Thr Pro Thr Ile 
625                 630                 635                 640 


Asn Met Pro Asn Thr Ser Val Val Leu Asp Thr Asp Ala Glu Phe Val 
                645                 650                 655     


Ser Asp Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
            660                 665                 670         


Gly Pro Pro Leu Pro Leu Pro Ser Val Ser Gln Ser His His Leu Phe 
        675                 680                 685             


Ser Ser Ile Leu Pro Ser Thr Arg Ala Ser Val His Leu Leu Lys Ser 
    690                 695                 700                 


Thr Ser Asp Ala Ser Thr Pro Trp Ser Ser Ser Pro Ser Pro Leu Pro 
705                 710                 715                 720 


Val Ser Leu Thr Thr Ser Thr Ser Ala Pro Leu Ser Val Ser Gln Thr 
                725                 730                 735     


Thr Leu Pro Gln Ser Ser Ser Thr Pro Val Leu Pro Arg Ala Arg Glu 
            740                 745                 750         


Thr Pro Val Thr Ser Phe Gln Thr Ser Thr Met Thr Ser Phe Met Thr 
        755                 760                 765             


Met Leu His Ser Ser Gln Thr Ala Asp Leu Lys Ser Gln Ser Thr Pro 
    770                 775                 780                 


His Gln Glu Lys Val Ile Thr Glu Ser Lys Ser Pro Ser Leu Val Ser 
785                 790                 795                 800 


Leu Pro Thr Glu Ser Thr Lys Ala Val Thr Thr Asn Ser Pro Leu Pro 
                805                 810                 815     


Pro Ser Leu Thr Glu Ser Ser Thr Glu Gln Thr Leu Pro Ala Thr Ser 
            820                 825                 830         


Thr Asn Leu Ala Gln Met Ser Pro Thr Phe Thr Thr Thr Ile Leu Lys 
        835                 840                 845             


Thr Ser Gln Pro Leu Met Thr Thr Pro Gly Thr Leu Ser Ser Thr Ala 
    850                 855                 860                 


Ser Leu Val Thr Gly Pro Ile Ala Val Gln Thr Thr Ala Gly Lys Gln 
865                 870                 875                 880 


Leu Ser Leu Thr His Pro Glu Ile Leu Val Pro Gln Ile Ser Thr Glu 
                885                 890                 895     


Gly Gly Ile Ser Thr Glu Arg Asn Arg Val Ile Val Asp Ala Thr Thr 
            900                 905                 910         


Gly Leu Ile Pro Leu Thr Ser Val Pro Thr Ser Ala Lys Glu Met Thr 
        915                 920                 925             


Thr Lys Leu Gly Val Thr Ala Glu Tyr Ser Pro Ala Ser Arg Ser Leu 
    930                 935                 940                 


Gly Thr Ser Pro Ser Pro Gln Thr Thr Val Val Ser Thr Ala Glu Asp 
945                 950                 955                 960 


Leu Ala Pro Lys Ser Ala Thr Phe Ala Val Gln Ser Ser Thr Gln Ser 
                965                 970                 975     


Pro Thr Thr Val Ser Ser Ser Ala Ser Val Asn Ser Cys Ala Val Asn 
            980                 985                 990         


Pro Cys Leu His Asn Gly Glu Cys  Val Ala Asp Asn Thr  Ser Arg Gly 
        995                 1000                 1005             


Tyr His  Cys Arg Cys Pro Pro  Ser Trp Gln Gly Asp  Asp Cys Ser 
    1010                 1015                 1020             


Val Asp  Val Asn Glu Cys Leu  Ser Asn Pro Cys Pro  Ser Thr Ala 
    1025                 1030                 1035             


Met Cys  Asn Asn Thr Gln Gly  Ser Phe Ile Cys Lys  Cys Pro Val 
    1040                 1045                 1050             


Gly Tyr  Gln Leu Glu Lys Gly  Ile Cys Asn Leu Val  Arg Thr Phe 
    1055                 1060                 1065             


Val Thr  Glu Phe Lys Leu Lys  Arg Thr Phe Leu Asn  Thr Thr Val 
    1070                 1075                 1080             


Glu Lys  His Ser Asp Leu Gln  Glu Val Glu Asn Glu  Ile Thr Lys 
    1085                 1090                 1095             


Thr Leu  Asn Met Cys Phe Ser  Ala Leu Pro Ser Tyr  Ile Arg Ser 
    1100                 1105                 1110             


Thr Val  His Ala Ser Arg Glu  Ser Asn Ala Val Val  Ile Ser Leu 
    1115                 1120                 1125             


Gln Thr  Thr Phe Ser Leu Ala  Ser Asn Val Thr Leu  Phe Asp Leu 
    1130                 1135                 1140             


Ala Asp  Arg Met Gln Lys Cys  Val Asn Ser Cys Lys  Ser Ser Ala 
    1145                 1150                 1155             


Glu Val  Cys Gln Leu Leu Gly  Ser Gln Arg Arg Ile  Phe Arg Ala 
    1160                 1165                 1170             


Gly Ser  Leu Cys Lys Arg Lys  Ser Pro Glu Cys Asp  Lys Asp Thr 
    1175                 1180                 1185             


Ser Ile  Cys Thr Asp Leu Asp  Gly Val Ala Leu Cys  Gln Cys Lys 
    1190                 1195                 1200             


Ser Gly  Tyr Phe Gln Phe Asn  Lys Met Asp His Ser  Cys Arg Ala 
    1205                 1210                 1215             


Cys Glu  Asp Gly Tyr Arg Leu  Glu Asn Glu Thr Cys  Met Ser Cys 
    1220                 1225                 1230             


Pro Phe  Gly Leu Gly Gly Leu  Asn Cys Gly Asn Pro  Tyr Gln Leu 
    1235                 1240                 1245             


Ile Thr  Val Val Ile Ala Ala  Ala Gly Gly Gly Leu  Leu Leu Ile 
    1250                 1255                 1260             


Leu Gly  Ile Ala Leu Ile Val  Thr Cys Cys Arg Lys  Asn Lys Asn 
    1265                 1270                 1275             


Asp Ile  Ser Lys Leu Ile Phe  Lys Ser Gly Asp Phe  Gln Met Ser 
    1280                 1285                 1290             


Pro Tyr  Ala Glu Tyr Pro Lys  Asn Pro Arg Ser Gln  Glu Trp Gly 
    1295                 1300                 1305             


Arg Glu  Ala Ile Glu Met His  Glu Asn Gly Ser Thr  Lys Asn Leu 
    1310                 1315                 1320             


Leu Gln  Met Thr Asp Val Tyr  Tyr Ser Pro Thr Ser  Val Arg Asn 
    1325                 1330                 1335             


Pro Glu  Leu Glu Arg Asn Gly  Leu Tyr Pro Ala Tyr  Thr Gly Leu 
    1340                 1345                 1350             


Pro Gly  Ser Arg His Ser Cys  Ile Phe Pro Gly Gln  Tyr Asn Pro 
    1355                 1360                 1365             


Ser Phe  Ile Ser Asp Glu Ser  Arg Arg Arg Asp Tyr  Phe 
    1370                 1375                 1380     


<210>  4711
<211>  789
<212>  PRT
<213>  Homo sapiens

<400>  4711

Met Glu Thr Leu Leu Gly Gly Leu Leu Ala Phe Gly Met Ala Phe Ala 
1               5                   10                  15      


Val Val Asp Ala Cys Pro Lys Tyr Cys Val Cys Gln Asn Leu Ser Glu 
            20                  25                  30          


Ser Leu Gly Thr Leu Cys Pro Ser Lys Gly Leu Leu Phe Val Pro Pro 
        35                  40                  45              


Asp Ile Asp Arg Arg Thr Val Glu Leu Arg Leu Gly Gly Asn Phe Ile 
    50                  55                  60                  


Ile His Ile Ser Arg Gln Asp Phe Ala Asn Met Thr Gly Leu Val Asp 
65                  70                  75                  80  


Leu Thr Leu Ser Arg Asn Thr Ile Ser His Ile Gln Pro Phe Ser Phe 
                85                  90                  95      


Leu Asp Leu Glu Ser Leu Arg Ser Leu His Leu Asp Ser Asn Arg Leu 
            100                 105                 110         


Pro Ser Leu Gly Glu Asp Thr Leu Arg Gly Leu Val Asn Leu Gln His 
        115                 120                 125             


Leu Ile Val Asn Asn Asn Gln Leu Gly Gly Ile Ala Asp Glu Ala Phe 
    130                 135                 140                 


Glu Asp Phe Leu Leu Thr Leu Glu Asp Leu Asp Leu Ser Tyr Asn Asn 
145                 150                 155                 160 


Leu His Gly Leu Pro Trp Asp Ser Val Arg Arg Met Val Asn Leu His 
                165                 170                 175     


Gln Leu Ser Leu Asp His Asn Leu Leu Asp His Ile Ala Glu Gly Thr 
            180                 185                 190         


Phe Ala Asp Leu Gln Lys Leu Ala Arg Leu Asp Leu Thr Ser Asn Arg 
        195                 200                 205             


Leu Gln Lys Leu Pro Pro Asp Pro Ile Phe Ala Arg Ser Gln Ala Ser 
    210                 215                 220                 


Ala Leu Thr Ala Thr Pro Phe Ala Pro Pro Leu Ser Phe Ser Phe Gly 
225                 230                 235                 240 


Gly Asn Pro Leu His Cys Asn Cys Glu Leu Leu Trp Leu Arg Arg Leu 
                245                 250                 255     


Glu Arg Asp Asp Asp Leu Glu Thr Cys Gly Ser Pro Gly Gly Leu Lys 
            260                 265                 270         


Gly Arg Tyr Phe Trp His Val Arg Glu Glu Glu Phe Val Cys Glu Pro 
        275                 280                 285             


Pro Leu Ile Thr Gln His Thr His Lys Leu Leu Val Leu Glu Gly Gln 
    290                 295                 300                 


Ala Ala Thr Leu Lys Cys Lys Ala Ile Gly Asp Pro Ser Pro Leu Ile 
305                 310                 315                 320 


His Trp Val Ala Pro Asp Asp Arg Leu Val Gly Asn Ser Ser Arg Thr 
                325                 330                 335     


Ala Val Tyr Asp Asn Gly Thr Leu Asp Ile Phe Ile Thr Thr Ser Gln 
            340                 345                 350         


Asp Ser Gly Ala Phe Thr Cys Ile Ala Ala Asn Ala Ala Gly Glu Ala 
        355                 360                 365             


Thr Ala Met Val Glu Val Ser Ile Val Gln Leu Pro His Leu Ser Asn 
    370                 375                 380                 


Ser Thr Ser Arg Thr Ala Pro Pro Lys Ser Arg Leu Ser Asp Ile Thr 
385                 390                 395                 400 


Gly Ser Ser Lys Thr Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Glu 
                405                 410                 415     


Pro Pro Lys Ser Pro Pro Glu Arg Ala Val Leu Val Ser Glu Val Thr 
            420                 425                 430         


Thr Thr Ser Ala Leu Val Lys Trp Ser Val Ser Lys Ser Ala Pro Arg 
        435                 440                 445             


Val Lys Met Tyr Gln Leu Gln Tyr Asn Cys Ser Asp Asp Glu Val Leu 
    450                 455                 460                 


Ile Tyr Arg Met Ile Pro Ala Ser Asn Lys Ala Phe Val Val Asn Asn 
465                 470                 475                 480 


Leu Val Ser Gly Thr Gly Tyr Asp Leu Cys Val Leu Ala Met Trp Asp 
                485                 490                 495     


Asp Thr Ala Thr Thr Leu Thr Ala Thr Asn Ile Val Gly Cys Ala Gln 
            500                 505                 510         


Phe Phe Thr Lys Ala Asp Tyr Pro Gln Cys Gln Ser Met His Ser Gln 
        515                 520                 525             


Ile Leu Gly Gly Thr Met Ile Leu Val Ile Gly Gly Ile Ile Val Ala 
    530                 535                 540                 


Thr Leu Leu Val Phe Ile Val Ile Leu Met Val Arg Tyr Lys Val Cys 
545                 550                 555                 560 


Asn His Glu Ala Pro Ser Lys Met Ala Ala Ala Val Ser Asn Val Tyr 
                565                 570                 575     


Ser Gln Thr Asn Gly Ala Gln Pro Pro Pro Pro Ser Ser Ala Pro Ala 
            580                 585                 590         


Gly Ala Pro Pro Gln Gly Pro Pro Lys Val Val Val Arg Asn Glu Leu 
        595                 600                 605             


Leu Asp Phe Thr Ala Ser Leu Ala Arg Ala Ser Asp Ser Ser Ser Ser 
    610                 615                 620                 


Ser Ser Leu Gly Ser Gly Glu Ala Ala Gly Leu Gly Arg Ala Pro Trp 
625                 630                 635                 640 


Arg Ile Pro Pro Ser Ala Pro Arg Pro Lys Pro Ser Leu Asp Arg Leu 
                645                 650                 655     


Met Gly Ala Phe Ala Ser Leu Asp Leu Lys Ser Gln Arg Lys Glu Glu 
            660                 665                 670         


Leu Leu Asp Ser Arg Thr Pro Ala Gly Arg Gly Ala Gly Thr Ser Ala 
        675                 680                 685             


Arg Gly His His Ser Asp Arg Glu Pro Leu Leu Gly Pro Pro Ala Ala 
    690                 695                 700                 


Arg Ala Arg Ser Leu Leu Pro Leu Pro Leu Glu Gly Lys Ala Lys Arg 
705                 710                 715                 720 


Ser His Ser Phe Asp Met Gly Asp Phe Ala Ala Ala Ala Ala Gly Gly 
                725                 730                 735     


Val Val Pro Gly Gly Tyr Ser Pro Pro Arg Lys Val Ser Asn Ile Trp 
            740                 745                 750         


Thr Lys Arg Ser Leu Ser Val Asn Gly Met Leu Leu Pro Phe Glu Glu 
        755                 760                 765             


Ser Asp Leu Val Gly Ala Arg Gly Thr Phe Gly Ser Ser Glu Trp Val 
    770                 775                 780                 


Met Glu Ser Thr Val 
785                 


<210>  4712
<211>  1771
<212>  PRT
<213>  Homo sapiens

<400>  4712

Met Ser Val Leu Ile Ser Gln Ser Val Ile Asn Tyr Val Glu Glu Glu 
1               5                   10                  15      


Asn Ile Pro Ala Leu Lys Ala Leu Leu Glu Lys Cys Lys Asp Val Asp 
            20                  25                  30          


Glu Arg Asn Glu Cys Gly Gln Thr Pro Leu Met Ile Ala Ala Glu Gln 
        35                  40                  45              


Gly Asn Leu Glu Ile Val Lys Glu Leu Ile Lys Asn Gly Ala Asn Cys 
    50                  55                  60                  


Asn Leu Glu Asp Leu Asp Asn Trp Thr Ala Leu Ile Ser Ala Ser Lys 
65                  70                  75                  80  


Glu Gly His Val His Ile Val Glu Glu Leu Leu Lys Cys Gly Val Asn 
                85                  90                  95      


Leu Glu His Arg Asp Met Gly Gly Trp Thr Ala Leu Met Trp Ala Cys 
            100                 105                 110         


Tyr Lys Gly Arg Thr Asp Val Val Glu Leu Leu Leu Ser His Gly Ala 
        115                 120                 125             


Asn Pro Ser Val Thr Gly Leu Tyr Ser Val Tyr Pro Ile Ile Trp Ala 
    130                 135                 140                 


Ala Gly Arg Gly His Ala Asp Ile Val His Leu Leu Leu Gln Asn Gly 
145                 150                 155                 160 


Ala Lys Val Asn Cys Ser Asp Lys Tyr Gly Thr Thr Pro Leu Val Trp 
                165                 170                 175     


Ala Ala Arg Lys Gly His Leu Glu Cys Val Lys His Leu Leu Ala Met 
            180                 185                 190         


Gly Ala Asp Val Asp Gln Glu Gly Ala Asn Ser Met Thr Ala Leu Ile 
        195                 200                 205             


Val Ala Val Lys Gly Gly Tyr Thr Gln Ser Val Lys Glu Ile Leu Lys 
    210                 215                 220                 


Arg Asn Pro Asn Val Asn Leu Thr Asp Lys Asp Gly Asn Thr Ala Leu 
225                 230                 235                 240 


Met Ile Ala Ser Lys Glu Gly His Thr Glu Ile Val Gln Asp Leu Leu 
                245                 250                 255     


Asp Ala Gly Thr Tyr Val Asn Ile Pro Asp Arg Ser Gly Asp Thr Val 
            260                 265                 270         


Leu Ile Gly Ala Val Arg Gly Gly His Val Glu Ile Val Arg Ala Leu 
        275                 280                 285             


Leu Gln Lys Tyr Ala Asp Ile Asp Ile Arg Gly Gln Asp Asn Lys Thr 
    290                 295                 300                 


Ala Leu Tyr Trp Ala Val Glu Lys Gly Asn Ala Thr Met Val Arg Asp 
305                 310                 315                 320 


Ile Leu Gln Cys Asn Pro Asp Thr Glu Ile Cys Thr Lys Asp Gly Glu 
                325                 330                 335     


Thr Pro Leu Ile Lys Ala Thr Lys Met Arg Asn Ile Glu Val Val Glu 
            340                 345                 350         


Leu Leu Leu Asp Lys Gly Ala Lys Val Ser Ala Val Asp Lys Lys Gly 
        355                 360                 365             


Asp Thr Pro Leu His Ile Ala Ile Arg Gly Arg Ser Arg Lys Leu Ala 
    370                 375                 380                 


Glu Leu Leu Leu Arg Asn Pro Lys Asp Gly Arg Leu Leu Tyr Arg Pro 
385                 390                 395                 400 


Asn Lys Ala Gly Glu Thr Pro Tyr Asn Ile Asp Cys Ser His Gln Lys 
                405                 410                 415     


Ser Ile Leu Thr Gln Ile Phe Gly Ala Arg His Leu Ser Pro Thr Glu 
            420                 425                 430         


Thr Asp Gly Asp Met Leu Gly Tyr Asp Leu Tyr Ser Ser Ala Leu Ala 
        435                 440                 445             


Asp Ile Leu Ser Glu Pro Thr Met Gln Pro Pro Ile Cys Val Gly Leu 
    450                 455                 460                 


Tyr Ala Gln Trp Gly Ser Gly Lys Ser Phe Leu Leu Lys Lys Leu Glu 
465                 470                 475                 480 


Asp Glu Met Lys Thr Phe Ala Gly Gln Gln Ile Glu Pro Leu Phe Gln 
                485                 490                 495     


Phe Ser Trp Leu Ile Val Phe Leu Thr Leu Leu Leu Cys Gly Gly Leu 
            500                 505                 510         


Gly Leu Leu Phe Ala Phe Thr Val His Pro Asn Leu Gly Ile Ala Val 
        515                 520                 525             


Ser Leu Ser Phe Leu Ala Leu Leu Tyr Ile Phe Phe Ile Val Ile Tyr 
    530                 535                 540                 


Phe Gly Gly Arg Arg Glu Gly Glu Ser Trp Asn Trp Ala Trp Val Leu 
545                 550                 555                 560 


Ser Thr Arg Leu Ala Arg His Ile Gly Tyr Leu Glu Leu Leu Leu Lys 
                565                 570                 575     


Leu Met Phe Val Asn Pro Pro Glu Leu Pro Glu Gln Thr Thr Lys Ala 
            580                 585                 590         


Leu Pro Val Arg Phe Leu Phe Thr Asp Tyr Asn Arg Leu Ser Ser Val 
        595                 600                 605             


Gly Gly Glu Thr Ser Leu Ala Glu Met Ile Ala Thr Leu Ser Asp Ala 
    610                 615                 620                 


Cys Glu Arg Glu Phe Gly Phe Leu Ala Thr Arg Leu Phe Arg Val Phe 
625                 630                 635                 640 


Lys Thr Glu Asp Thr Gln Gly Lys Lys Lys Trp Lys Lys Thr Cys Cys 
                645                 650                 655     


Leu Pro Ser Phe Val Ile Phe Leu Phe Ile Ile Gly Cys Ile Ile Ser 
            660                 665                 670         


Gly Ile Thr Leu Leu Ala Ile Phe Arg Val Asp Pro Lys His Leu Thr 
        675                 680                 685             


Val Asn Ala Val Leu Ile Ser Ile Ala Ser Val Val Gly Leu Ala Phe 
    690                 695                 700                 


Val Leu Asn Cys Arg Thr Trp Trp Gln Val Leu Asp Ser Leu Leu Asn 
705                 710                 715                 720 


Ser Gln Arg Lys Arg Leu His Asn Ala Ala Ser Lys Leu His Lys Leu 
                725                 730                 735     


Lys Ser Glu Gly Phe Met Lys Val Leu Lys Cys Glu Val Glu Leu Met 
            740                 745                 750         


Ala Arg Met Ala Lys Thr Ile Asp Ser Phe Thr Gln Asn Gln Thr Arg 
        755                 760                 765             


Leu Val Val Ile Ile Asp Gly Leu Asp Ala Cys Glu Gln Asp Lys Val 
    770                 775                 780                 


Leu Gln Met Leu Asp Thr Val Arg Val Leu Phe Ser Lys Gly Pro Phe 
785                 790                 795                 800 


Ile Ala Ile Phe Ala Ser Asp Pro His Ile Ile Ile Lys Ala Ile Asn 
                805                 810                 815     


Gln Asn Leu Asn Ser Val Leu Arg Asp Ser Asn Ile Asn Gly His Asp 
            820                 825                 830         


Tyr Met Arg Asn Ile Val His Leu Pro Val Phe Leu Asn Ser Arg Gly 
        835                 840                 845             


Leu Ser Asn Ala Arg Lys Phe Leu Val Thr Ser Ala Thr Asn Gly Asp 
    850                 855                 860                 


Val Pro Cys Ser Asp Thr Thr Gly Ile Gln Glu Asp Ala Asp Arg Arg 
865                 870                 875                 880 


Val Ser Gln Asn Ser Leu Gly Glu Met Thr Lys Leu Gly Ser Lys Thr 
                885                 890                 895     


Ala Leu Asn Arg Arg Asp Thr Tyr Arg Arg Arg Gln Met Gln Arg Thr 
            900                 905                 910         


Ile Thr Arg Gln Met Ser Phe Asp Leu Thr Lys Leu Leu Val Thr Glu 
        915                 920                 925             


Asp Trp Phe Ser Asp Ile Ser Pro Gln Thr Met Arg Arg Leu Leu Asn 
    930                 935                 940                 


Ile Val Ser Val Thr Gly Arg Leu Leu Arg Ala Asn Gln Ile Ser Phe 
945                 950                 955                 960 


Asn Trp Asp Arg Leu Ala Ser Trp Ile Asn Leu Thr Glu Gln Trp Pro 
                965                 970                 975     


Tyr Arg Thr Ser Trp Leu Ile Leu Tyr Leu Glu Glu Thr Glu Gly Ile 
            980                 985                 990         


Pro Asp Gln Met Thr Leu Lys Thr  Ile Tyr Glu Arg Ile  Ser Lys Asn 
        995                 1000                 1005             


Ile Pro  Thr Thr Lys Asp Val  Glu Pro Leu Leu Glu  Ile Asp Gly 
    1010                 1015                 1020             


Asp Ile  Arg Asn Phe Glu Val  Phe Leu Ser Ser Arg  Thr Pro Val 
    1025                 1030                 1035             


Leu Val  Ala Arg Asp Val Lys  Val Phe Leu Pro Cys  Thr Val Asn 
    1040                 1045                 1050             


Leu Asp  Pro Lys Leu Arg Glu  Ile Ile Ala Asp Val  Arg Ala Ala 
    1055                 1060                 1065             


Arg Glu  Gln Ile Ser Ile Gly  Gly Leu Ala Tyr Pro  Pro Leu Pro 
    1070                 1075                 1080             


Leu His  Glu Gly Pro Pro Arg  Ala Pro Ser Gly Tyr  Ser Gln Pro 
    1085                 1090                 1095             


Pro Ser  Val Cys Ser Ser Thr  Ser Phe Asn Gly Pro  Phe Ala Gly 
    1100                 1105                 1110             


Gly Val  Val Ser Pro Gln Pro  His Ser Ser Tyr Tyr  Ser Gly Met 
    1115                 1120                 1125             


Thr Gly  Pro Gln His Pro Phe  Tyr Asn Arg Pro Phe  Phe Ala Pro 
    1130                 1135                 1140             


Tyr Leu  Tyr Thr Pro Arg Tyr  Tyr Pro Gly Gly Ser  Gln His Leu 
    1145                 1150                 1155             


Ile Ser  Arg Pro Ser Val Lys  Thr Ser Leu Pro Arg  Asp Gln Asn 
    1160                 1165                 1170             


Asn Gly  Leu Glu Val Ile Lys  Glu Asp Ala Ala Glu  Gly Leu Ser 
    1175                 1180                 1185             


Ser Pro  Thr Asp Ser Ser Arg  Gly Ser Gly Pro Ala  Pro Gly Pro 
    1190                 1195                 1200             


Val Val  Leu Leu Asn Ser Leu  Asn Val Asp Ala Val  Cys Glu Lys 
    1205                 1210                 1215             


Leu Lys  Gln Ile Glu Gly Leu  Asp Gln Ser Met Leu  Pro Gln Tyr 
    1220                 1225                 1230             


Cys Thr  Thr Ile Lys Lys Ala  Asn Ile Asn Gly Arg  Val Leu Ala 
    1235                 1240                 1245             


Gln Cys  Asn Ile Asp Glu Leu  Lys Lys Glu Met Asn  Met Asn Phe 
    1250                 1255                 1260             


Gly Asp  Trp His Leu Phe Arg  Ser Thr Val Leu Glu  Met Arg Asn 
    1265                 1270                 1275             


Ala Glu  Ser His Val Val Pro  Glu Asp Pro Arg Phe  Leu Ser Glu 
    1280                 1285                 1290             


Ser Ser  Ser Gly Pro Ala Pro  His Gly Glu Pro Ala  Arg Arg Ala 
    1295                 1300                 1305             


Ser His  Asn Glu Leu Pro His  Thr Glu Leu Ser Ser  Gln Thr Pro 
    1310                 1315                 1320             


Tyr Thr  Leu Asn Phe Ser Phe  Glu Glu Leu Asn Thr  Leu Gly Leu 
    1325                 1330                 1335             


Asp Glu  Gly Ala Pro Arg His  Ser Asn Leu Ser Trp  Gln Ser Gln 
    1340                 1345                 1350             


Thr Arg  Arg Thr Pro Ser Leu  Ser Ser Leu Asn Ser  Gln Asp Ser 
    1355                 1360                 1365             


Ser Ile  Glu Ile Ser Lys Leu  Thr Asp Lys Val Gln  Ala Glu Tyr 
    1370                 1375                 1380             


Arg Asp  Ala Tyr Arg Glu Tyr  Ile Ala Gln Met Ser  Gln Leu Glu 
    1385                 1390                 1395             


Gly Gly  Pro Gly Ser Thr Thr  Ile Ser Gly Arg Ser  Ser Pro His 
    1400                 1405                 1410             


Ser Thr  Tyr Tyr Met Gly Gln  Ser Ser Ser Gly Gly  Ser Ile His 
    1415                 1420                 1425             


Ser Asn  Leu Glu Gln Glu Lys  Gly Lys Asp Ser Glu  Pro Lys Pro 
    1430                 1435                 1440             


Asp Asp  Gly Arg Lys Ser Phe  Leu Met Lys Arg Gly  Asp Val Ile 
    1445                 1450                 1455             


Asp Tyr  Ser Ser Ser Gly Val  Ser Thr Asn Asp Ala  Ser Pro Leu 
    1460                 1465                 1470             


Asp Pro  Ile Thr Glu Glu Asp  Glu Lys Ser Asp Gln  Ser Gly Ser 
    1475                 1480                 1485             


Lys Leu  Leu Pro Gly Lys Lys  Ser Ser Glu Arg Ser  Ser Leu Phe 
    1490                 1495                 1500             


Gln Thr  Asp Leu Lys Leu Lys  Gly Ser Gly Leu Arg  Tyr Gln Lys 
    1505                 1510                 1515             


Leu Pro  Ser Asp Glu Asp Glu  Ser Gly Thr Glu Glu  Ser Asp Asn 
    1520                 1525                 1530             


Thr Pro  Leu Leu Lys Asp Asp  Lys Asp Arg Lys Ala  Glu Gly Lys 
    1535                 1540                 1545             


Val Glu  Arg Val Pro Lys Ser  Pro Glu His Ser Ala  Glu Pro Ile 
    1550                 1555                 1560             


Arg Thr  Phe Ile Lys Ala Lys  Glu Tyr Leu Ser Asp  Ala Leu Leu 
    1565                 1570                 1575             


Asp Lys  Lys Asp Ser Ser Asp  Ser Gly Val Arg Ser  Ser Glu Ser 
    1580                 1585                 1590             


Ser Pro  Asn His Ser Leu His  Asn Glu Val Ala Asp  Asp Ser Gln 
    1595                 1600                 1605             


Leu Glu  Lys Ala Asn Leu Ile  Glu Leu Glu Asp Asp  Ser His Ser 
    1610                 1615                 1620             


Gly Lys  Arg Gly Ile Pro His  Ser Leu Ser Gly Leu  Gln Asp Pro 
    1625                 1630                 1635             


Ile Ile  Ala Arg Met Ser Ile  Cys Ser Glu Asp Lys  Lys Ser Pro 
    1640                 1645                 1650             


Ser Glu  Cys Ser Leu Ile Ala  Ser Ser Pro Glu Glu  Asn Trp Pro 
    1655                 1660                 1665             


Ala Cys  Gln Lys Ala Tyr Asn  Leu Asn Arg Thr Pro  Ser Thr Val 
    1670                 1675                 1680             


Thr Leu  Asn Asn Asn Ser Ala  Pro Ala Asn Arg Ala  Asn Gln Asn 
    1685                 1690                 1695             


Phe Asp  Glu Met Glu Gly Ile  Arg Glu Thr Ser Gln  Val Ile Leu 
    1700                 1705                 1710             


Arg Pro  Ser Ser Ser Pro Asn  Pro Thr Thr Ile Gln  Asn Glu Asn 
    1715                 1720                 1725             


Leu Lys  Ser Met Thr His Lys  Arg Ser Gln Arg Ser  Ser Tyr Thr 
    1730                 1735                 1740             


Arg Leu  Ser Lys Asp Pro Pro  Glu Leu His Ala Ala  Ala Ser Ser 
    1745                 1750                 1755             


Glu Ser  Thr Gly Phe Gly Glu  Glu Arg Glu Ser Ile  Leu 
    1760                 1765                 1770     


<210>  4713
<211>  757
<212>  PRT
<213>  Homo sapiens

<400>  4713

Met Ser Glu Asn Ser Ser Asp Ser Asp Ser Ser Cys Gly Trp Thr Val 
1               5                   10                  15      


Ile Ser His Glu Gly Ser Asp Ile Glu Met Leu Asn Ser Val Thr Pro 
            20                  25                  30          


Thr Asp Ser Cys Glu Pro Ala Pro Glu Cys Ser Ser Leu Glu Gln Glu 
        35                  40                  45              


Glu Leu Gln Ala Leu Gln Ile Glu Gln Gly Glu Ser Ser Gln Asn Gly 
    50                  55                  60                  


Thr Val Leu Met Glu Glu Thr Ala Tyr Pro Ala Leu Glu Glu Thr Ser 
65                  70                  75                  80  


Ser Thr Ile Glu Ala Glu Glu Gln Lys Ile Pro Glu Asp Ser Ile Tyr 
                85                  90                  95      


Ile Gly Thr Ala Ser Asp Asp Ser Asp Ile Val Thr Leu Glu Pro Pro 
            100                 105                 110         


Lys Leu Glu Glu Ile Gly Asn Gln Glu Val Val Ile Val Glu Glu Ala 
        115                 120                 125             


Gln Ser Ser Glu Asp Phe Asn Met Gly Ser Ser Ser Ser Ser Gln Tyr 
    130                 135                 140                 


Thr Phe Cys Gln Pro Glu Thr Val Phe Ser Ser Gln Pro Ser Asp Asp 
145                 150                 155                 160 


Glu Ser Ser Ser Asp Glu Thr Ser Asn Gln Pro Ser Pro Ala Phe Arg 
                165                 170                 175     


Arg Arg Arg Ala Arg Lys Lys Thr Val Ser Ala Ser Glu Ser Glu Asp 
            180                 185                 190         


Arg Leu Val Ala Glu Gln Glu Thr Glu Pro Ser Lys Glu Leu Ser Lys 
        195                 200                 205             


Arg Gln Phe Ser Ser Gly Leu Asn Lys Cys Val Ile Leu Ala Leu Val 
    210                 215                 220                 


Ile Ala Ile Ser Met Gly Phe Gly His Phe Tyr Gly Thr Ile Gln Ile 
225                 230                 235                 240 


Gln Lys Arg Gln Gln Leu Val Arg Lys Ile His Glu Asp Glu Leu Asn 
                245                 250                 255     


Asp Met Lys Asp Tyr Leu Ser Gln Cys Gln Gln Glu Gln Glu Ser Phe 
            260                 265                 270         


Ile Asp Tyr Lys Ser Leu Lys Glu Asn Leu Ala Arg Cys Trp Thr Leu 
        275                 280                 285             


Thr Glu Ala Glu Lys Met Ser Phe Glu Thr Gln Lys Thr Asn Leu Ala 
    290                 295                 300                 


Thr Glu Asn Gln Tyr Leu Arg Val Ser Leu Glu Lys Glu Glu Lys Ala 
305                 310                 315                 320 


Leu Ser Ser Leu Gln Glu Glu Leu Asn Lys Leu Arg Glu Gln Ile Arg 
                325                 330                 335     


Ile Leu Glu Asp Lys Gly Thr Ser Thr Glu Leu Val Lys Glu Asn Gln 
            340                 345                 350         


Lys Leu Lys Gln His Leu Glu Glu Glu Lys Gln Lys Lys His Ser Phe 
        355                 360                 365             


Leu Ser Gln Arg Glu Thr Leu Leu Thr Glu Ala Lys Met Leu Lys Arg 
    370                 375                 380                 


Glu Leu Glu Arg Glu Arg Leu Val Thr Thr Ala Leu Arg Gly Glu Leu 
385                 390                 395                 400 


Gln Gln Leu Ser Gly Ser Gln Leu His Gly Lys Ser Asp Ser Pro Asn 
                405                 410                 415     


Val Tyr Thr Glu Lys Lys Glu Ile Ala Ile Leu Arg Glu Arg Leu Thr 
            420                 425                 430         


Glu Leu Glu Arg Lys Leu Thr Phe Glu Gln Gln Arg Ser Asp Leu Trp 
        435                 440                 445             


Glu Arg Leu Tyr Val Glu Ala Lys Asp Gln Asn Gly Lys Gln Gly Thr 
    450                 455                 460                 


Asp Gly Lys Lys Lys Gly Gly Arg Gly Ser His Arg Ala Lys Asn Lys 
465                 470                 475                 480 


Ser Lys Glu Thr Phe Leu Gly Ser Val Lys Glu Thr Phe Asp Ala Met 
                485                 490                 495     


Lys Asn Ser Thr Lys Glu Phe Val Arg His His Lys Glu Lys Ile Lys 
            500                 505                 510         


Gln Ala Lys Glu Ala Val Lys Glu Asn Leu Lys Lys Phe Ser Asp Ser 
        515                 520                 525             


Val Lys Ser Thr Phe Arg His Phe Lys Asp Thr Thr Lys Asn Ile Phe 
    530                 535                 540                 


Asp Glu Lys Gly Asn Lys Arg Phe Gly Ala Thr Lys Glu Ala Ala Glu 
545                 550                 555                 560 


Lys Pro Arg Thr Val Phe Ser Asp Tyr Leu His Pro Gln Tyr Lys Ala 
                565                 570                 575     


Pro Thr Glu Asn His His Asn Arg Gly Pro Thr Met Gln Asn Asp Gly 
            580                 585                 590         


Arg Lys Glu Lys Pro Val His Phe Lys Glu Phe Arg Lys Asn Thr Asn 
        595                 600                 605             


Ser Lys Lys Cys Ser Pro Gly His Asp Cys Arg Glu Asn Ser His Ser 
    610                 615                 620                 


Phe Arg Lys Ala Cys Ser Gly Val Phe Asp Cys Ala Gln Gln Glu Ser 
625                 630                 635                 640 


Met Ser Leu Phe Asn Thr Val Val Asn Pro Ile Arg Met Asp Glu Phe 
                645                 650                 655     


Arg Gln Ile Ile Gln Arg Tyr Met Leu Lys Glu Leu Asp Thr Phe Cys 
            660                 665                 670         


His Trp Asn Glu Leu Asp Gln Phe Ile Asn Lys Phe Phe Leu Asn Gly 
        675                 680                 685             


Val Phe Ile His Asp Gln Lys Leu Phe Thr Asp Phe Val Asn Asp Val 
    690                 695                 700                 


Lys Asp Tyr Leu Arg Asn Met Lys Glu Tyr Glu Val Asp Asn Asp Gly 
705                 710                 715                 720 


Val Phe Glu Lys Leu Asp Glu Tyr Ile Tyr Arg His Phe Phe Gly His 
                725                 730                 735     


Thr Phe Ser Pro Pro Tyr Gly Pro Arg Ser Val Tyr Ile Lys Pro Cys 
            740                 745                 750         


His Tyr Ser Ser Leu 
        755         


<210>  4714
<211>  540
<212>  PRT
<213>  Homo sapiens

<400>  4714

Met Pro Phe Ala Glu Asp Lys Thr Tyr Lys Tyr Ile Cys Arg Asn Phe 
1               5                   10                  15      


Ser Asn Phe Cys Asn Val Asp Val Val Glu Ile Leu Pro Tyr Leu Pro 
            20                  25                  30          


Cys Leu Thr Ala Arg Asp Gln Asp Arg Leu Arg Ala Thr Cys Thr Leu 
        35                  40                  45              


Ser Gly Asn Arg Asp Thr Leu Trp His Leu Phe Asn Thr Leu Gln Arg 
    50                  55                  60                  


Arg Pro Gly Trp Val Glu Tyr Phe Ile Ala Ala Leu Arg Gly Cys Glu 
65                  70                  75                  80  


Leu Val Asp Leu Ala Asp Glu Val Ala Ser Val Tyr Gln Ser Tyr Gln 
                85                  90                  95      


Pro Arg Thr Ser Asp Arg Pro Pro Asp Pro Leu Glu Pro Pro Ser Leu 
            100                 105                 110         


Pro Ala Glu Arg Pro Gly Pro Pro Thr Pro Ala Ala Ala His Ser Ile 
        115                 120                 125             


Pro Tyr Asn Ser Cys Arg Glu Lys Glu Pro Ser Tyr Pro Met Pro Val 
    130                 135                 140                 


Gln Glu Thr Gln Ala Pro Glu Ser Pro Gly Glu Asn Ser Glu Gln Ala 
145                 150                 155                 160 


Leu Gln Thr Leu Ser Pro Arg Ala Ile Pro Arg Asn Pro Asp Gly Gly 
                165                 170                 175     


Pro Leu Glu Ser Ser Ser Asp Leu Ala Ala Leu Ser Pro Leu Thr Ser 
            180                 185                 190         


Ser Gly His Gln Glu Gln Asp Thr Glu Leu Gly Ser Thr His Thr Ala 
        195                 200                 205             


Gly Ala Thr Ser Ser Leu Thr Pro Ser Arg Gly Pro Val Ser Pro Ser 
    210                 215                 220                 


Val Ser Phe Gln Pro Leu Ala Arg Ser Thr Pro Arg Ala Ser Arg Leu 
225                 230                 235                 240 


Pro Gly Pro Thr Gly Ser Val Val Ser Thr Gly Thr Ser Phe Ser Ser 
                245                 250                 255     


Ser Ser Pro Gly Leu Ala Ser Ala Gly Ala Ala Glu Gly Lys Gln Gly 
            260                 265                 270         


Ala Glu Ser Asp Gln Ala Glu Pro Ile Ile Cys Ser Ser Gly Ala Glu 
        275                 280                 285             


Ala Pro Ala Asn Ser Leu Pro Ser Lys Val Pro Thr Thr Leu Met Pro 
    290                 295                 300                 


Val Asn Thr Val Ala Leu Lys Val Pro Ala Asn Pro Ala Ser Val Ser 
305                 310                 315                 320 


Thr Val Pro Ser Lys Leu Pro Thr Ser Ser Lys Pro Pro Gly Ala Val 
                325                 330                 335     


Pro Ser Asn Ala Leu Thr Asn Pro Ala Pro Ser Lys Leu Pro Ile Asn 
            340                 345                 350         


Ser Thr Arg Ala Gly Met Val Pro Ser Lys Val Pro Thr Ser Met Val 
        355                 360                 365             


Leu Thr Lys Val Ser Ala Ser Thr Val Pro Thr Asp Gly Ser Ser Arg 
    370                 375                 380                 


Asn Glu Glu Thr Pro Ala Ala Pro Thr Pro Ala Gly Ala Thr Gly Gly 
385                 390                 395                 400 


Ser Ser Ala Trp Leu Asp Ser Ser Ser Glu Asn Arg Gly Leu Gly Ser 
                405                 410                 415     


Glu Leu Ser Lys Pro Gly Val Leu Ala Ser Gln Val Asp Ser Pro Phe 
            420                 425                 430         


Ser Gly Cys Phe Glu Asp Leu Ala Ile Ser Ala Ser Thr Ser Leu Gly 
        435                 440                 445             


Met Gly Pro Cys His Gly Pro Glu Glu Asn Glu Tyr Lys Ser Glu Gly 
    450                 455                 460                 


Thr Phe Gly Ile His Val Ala Glu Asn Pro Ser Ile Gln Leu Leu Glu 
465                 470                 475                 480 


Gly Asn Pro Gly Pro Pro Ala Asp Pro Asp Gly Gly Pro Arg Pro Gln 
                485                 490                 495     


Ala Asp Arg Lys Phe Gln Glu Arg Glu Val Pro Cys His Arg Pro Ser 
            500                 505                 510         


Pro Gly Ala Leu Trp Leu Gln Val Ala Val Thr Gly Val Leu Val Val 
        515                 520                 525             


Thr Leu Leu Val Val Leu Tyr Arg Arg Arg Leu His 
    530                 535                 540 


<210>  4715
<211>  436
<212>  PRT
<213>  Homo sapiens

<400>  4715

Met Leu Leu Ser Pro Lys Phe Ser Leu Ser Thr Ile His Ile Arg Leu 
1               5                   10                  15      


Thr Ala Lys Gly Leu Leu Arg Asn Leu Arg Leu Pro Ser Gly Phe Arg 
            20                  25                  30          


Arg Ser Thr Val Val Phe His Thr Val Glu Lys Ser Arg Gln Lys Asn 
        35                  40                  45              


Pro Arg Ser Leu Cys Ile Gln Pro Gln Thr Ala Pro Asp Ala Leu Pro 
    50                  55                  60                  


Pro Glu Lys Thr Leu Glu Leu Thr Gln Tyr Lys Thr Lys Cys Glu Asn 
65                  70                  75                  80  


Gln Ser Gly Phe Ile Leu Gln Leu Lys Gln Leu Leu Ala Cys Gly Asn 
                85                  90                  95      


Thr Lys Phe Glu Ala Leu Thr Val Val Ile Gln His Leu Leu Ser Glu 
            100                 105                 110         


Arg Glu Glu Ala Leu Lys Gln His Lys Thr Leu Ser Gln Glu Leu Val 
        115                 120                 125             


Asn Leu Arg Gly Glu Leu Val Thr Ala Ser Thr Thr Cys Glu Lys Leu 
    130                 135                 140                 


Glu Lys Ala Arg Asn Glu Leu Gln Thr Val Tyr Glu Ala Phe Val Gln 
145                 150                 155                 160 


Gln His Gln Ala Glu Lys Thr Glu Arg Glu Asn Arg Leu Lys Glu Phe 
                165                 170                 175     


Tyr Thr Arg Glu Tyr Glu Lys Leu Arg Asp Thr Tyr Ile Glu Glu Ala 
            180                 185                 190         


Glu Lys Tyr Lys Met Gln Leu Gln Glu Gln Phe Asp Asn Leu Asn Ala 
        195                 200                 205             


Ala His Glu Thr Ser Lys Leu Glu Ile Glu Ala Ser His Ser Glu Lys 
    210                 215                 220                 


Leu Glu Leu Leu Lys Lys Ala Tyr Glu Ala Ser Leu Ser Glu Ile Lys 
225                 230                 235                 240 


Lys Gly His Glu Ile Glu Lys Lys Ser Leu Glu Asp Leu Leu Ser Glu 
                245                 250                 255     


Lys Gln Glu Ser Leu Glu Lys Gln Ile Asn Asp Leu Lys Ser Glu Asn 
            260                 265                 270         


Asp Ala Leu Asn Glu Lys Leu Lys Ser Glu Glu Gln Lys Arg Arg Ala 
        275                 280                 285             


Arg Glu Lys Ala Asn Leu Lys Asn Pro Gln Ile Met Tyr Leu Glu Gln 
    290                 295                 300                 


Glu Leu Glu Ser Leu Lys Ala Val Leu Glu Ile Lys Asn Glu Lys Leu 
305                 310                 315                 320 


His Gln Gln Asp Ile Lys Leu Met Lys Met Glu Lys Leu Val Asp Asn 
                325                 330                 335     


Asn Thr Ala Leu Val Asp Lys Leu Lys Arg Phe Gln Gln Glu Asn Glu 
            340                 345                 350         


Glu Leu Lys Ala Arg Met Asp Lys His Met Ala Ile Ser Arg Gln Leu 
        355                 360                 365             


Ser Thr Glu Gln Ala Val Leu Gln Glu Ser Leu Glu Lys Glu Ser Lys 
    370                 375                 380                 


Val Asn Lys Arg Leu Ser Met Glu Asn Glu Glu Leu Leu Trp Lys Leu 
385                 390                 395                 400 


His Asn Gly Asp Leu Cys Ser Pro Lys Arg Ser Pro Thr Ser Ser Ala 
                405                 410                 415     


Ile Pro Leu Gln Ser Pro Arg Asn Ser Gly Ser Phe Pro Ser Pro Ser 
            420                 425                 430         


Ile Ser Pro Arg 
        435     


<210>  4716
<211>  1215
<212>  PRT
<213>  Homo sapiens

<400>  4716

Met Gly Ala Met Ala Tyr Pro Leu Leu Leu Cys Leu Leu Leu Ala Gln 
1               5                   10                  15      


Leu Gly Leu Gly Ala Val Gly Ala Ser Arg Asp Pro Gln Gly Arg Pro 
            20                  25                  30          


Asp Ser Pro Arg Glu Arg Thr Pro Lys Gly Lys Pro His Ala Gln Gln 
        35                  40                  45              


Pro Gly Arg Ala Ser Ala Ser Asp Ser Ser Ala Pro Trp Ser Arg Ser 
    50                  55                  60                  


Thr Asp Gly Thr Ile Leu Ala Gln Lys Leu Ala Glu Glu Val Pro Met 
65                  70                  75                  80  


Asp Val Ala Ser Tyr Leu Tyr Thr Gly Asp Ser His Gln Leu Lys Arg 
                85                  90                  95      


Ala Asn Cys Ser Gly Arg Tyr Glu Leu Ala Gly Leu Pro Gly Lys Trp 
            100                 105                 110         


Pro Ala Leu Ala Ser Ala His Pro Ser Leu His Arg Ala Leu Asp Thr 
        115                 120                 125             


Leu Thr His Ala Thr Asn Phe Leu Asn Val Met Leu Gln Ser Asn Lys 
    130                 135                 140                 


Ser Arg Glu Gln Asn Leu Gln Asp Asp Leu Asp Trp Tyr Gln Ala Leu 
145                 150                 155                 160 


Val Trp Ser Leu Leu Glu Gly Glu Pro Ser Ile Ser Arg Ala Ala Ile 
                165                 170                 175     


Thr Phe Ser Thr Asp Ser Leu Ser Ala Pro Ala Pro Gln Val Phe Leu 
            180                 185                 190         


Gln Ala Thr Arg Glu Glu Ser Arg Ile Leu Leu Gln Asp Leu Ser Ser 
        195                 200                 205             


Ser Ala Pro His Leu Ala Asn Ala Thr Leu Glu Thr Glu Trp Phe His 
    210                 215                 220                 


Gly Leu Arg Arg Lys Trp Arg Pro His Leu His Arg Arg Gly Pro Asn 
225                 230                 235                 240 


Gln Gly Pro Arg Gly Leu Gly His Ser Trp Arg Arg Lys Asp Gly Leu 
                245                 250                 255     


Gly Gly Asp Lys Ser His Phe Lys Trp Ser Pro Pro Tyr Leu Glu Cys 
            260                 265                 270         


Glu Asn Gly Ser Tyr Lys Pro Gly Trp Leu Val Thr Leu Ser Ser Ala 
        275                 280                 285             


Ile Tyr Gly Leu Gln Pro Asn Leu Val Pro Glu Phe Arg Gly Val Met 
    290                 295                 300                 


Lys Val Asp Ile Asn Leu Gln Lys Val Asp Ile Asp Gln Cys Ser Ser 
305                 310                 315                 320 


Asp Gly Trp Phe Ser Gly Thr His Lys Cys His Leu Asn Asn Ser Glu 
                325                 330                 335     


Cys Met Pro Ile Lys Gly Leu Gly Phe Val Leu Gly Ala Tyr Glu Cys 
            340                 345                 350         


Ile Cys Lys Ala Gly Phe Tyr His Pro Gly Val Leu Pro Val Asn Asn 
        355                 360                 365             


Phe Arg Arg Arg Gly Pro Asp Gln His Ile Ser Gly Ser Thr Lys Asp 
    370                 375                 380                 


Val Ser Glu Glu Ala Tyr Val Cys Leu Pro Cys Arg Glu Gly Cys Pro 
385                 390                 395                 400 


Phe Cys Ala Asp Asp Ser Pro Cys Phe Val Gln Glu Asp Lys Tyr Leu 
                405                 410                 415     


Arg Leu Ala Ile Ile Ser Phe Gln Ala Leu Cys Met Leu Leu Asp Phe 
            420                 425                 430         


Val Ser Met Leu Val Val Tyr His Phe Arg Lys Ala Lys Ser Ile Arg 
        435                 440                 445             


Ala Ser Gly Leu Ile Leu Leu Glu Thr Ile Leu Phe Gly Ser Leu Leu 
    450                 455                 460                 


Leu Tyr Phe Pro Val Val Ile Leu Tyr Phe Glu Pro Ser Thr Phe Arg 
465                 470                 475                 480 


Cys Ile Leu Leu Arg Trp Ala Arg Leu Leu Gly Phe Ala Thr Val Tyr 
                485                 490                 495     


Gly Thr Val Thr Leu Lys Leu His Arg Val Leu Lys Val Phe Leu Ser 
            500                 505                 510         


Arg Thr Ala Gln Arg Ile Pro Tyr Met Thr Gly Gly Arg Val Met Arg 
        515                 520                 525             


Met Leu Ala Val Ile Leu Leu Val Val Phe Trp Phe Leu Ile Gly Trp 
    530                 535                 540                 


Thr Ser Ser Val Cys Gln Asn Leu Glu Lys Gln Ile Ser Leu Ile Gly 
545                 550                 555                 560 


Gln Gly Lys Thr Ser Asp His Leu Ile Phe Asn Met Cys Leu Ile Asp 
                565                 570                 575     


Arg Trp Asp Tyr Met Thr Ala Val Ala Glu Phe Leu Phe Leu Leu Trp 
            580                 585                 590         


Gly Val Tyr Leu Cys Tyr Ala Val Arg Thr Val Pro Ser Ala Phe His 
        595                 600                 605             


Glu Pro Arg Tyr Met Ala Val Ala Val His Asn Glu Leu Ile Ile Ser 
    610                 615                 620                 


Ala Ile Phe His Thr Ile Arg Phe Val Leu Ala Ser Arg Leu Gln Ser 
625                 630                 635                 640 


Asp Trp Met Leu Met Leu Tyr Phe Ala His Thr His Leu Thr Val Thr 
                645                 650                 655     


Val Thr Ile Gly Leu Leu Leu Ile Pro Lys Phe Ser His Ser Ser Asn 
            660                 665                 670         


Asn Pro Arg Asp Asp Ile Ala Thr Glu Ala Tyr Glu Asp Glu Leu Asp 
        675                 680                 685             


Met Gly Arg Ser Gly Ser Tyr Leu Asn Ser Ser Ile Asn Ser Ala Trp 
    690                 695                 700                 


Ser Glu His Ser Leu Asp Pro Glu Asp Ile Arg Asp Glu Leu Lys Lys 
705                 710                 715                 720 


Leu Tyr Ala Gln Leu Glu Ile Tyr Lys Arg Lys Lys Met Ile Thr Asn 
                725                 730                 735     


Asn Pro His Leu Gln Lys Lys Arg Cys Ser Lys Lys Gly Leu Gly Arg 
            740                 745                 750         


Ser Ile Met Arg Arg Ile Thr Glu Ile Pro Glu Thr Val Ser Arg Gln 
        755                 760                 765             


Cys Ser Lys Glu Asp Lys Glu Gly Ala Asp His Gly Thr Ala Lys Gly 
    770                 775                 780                 


Thr Ala Leu Ile Arg Lys Asn Pro Pro Glu Ser Ser Gly Asn Thr Gly 
785                 790                 795                 800 


Lys Ser Lys Glu Glu Thr Leu Lys Asn Arg Val Phe Ser Leu Lys Lys 
                805                 810                 815     


Ser His Ser Thr Tyr Asp His Val Arg Asp Gln Thr Glu Glu Ser Ser 
            820                 825                 830         


Ser Leu Pro Thr Glu Ser Gln Glu Glu Glu Thr Thr Glu Asn Ser Thr 
        835                 840                 845             


Leu Glu Ser Leu Ser Gly Lys Lys Leu Thr Gln Lys Leu Lys Glu Asp 
    850                 855                 860                 


Ser Glu Ala Glu Ser Thr Glu Ser Val Pro Leu Val Cys Lys Ser Ala 
865                 870                 875                 880 


Ser Ala His Asn Leu Ser Ser Glu Lys Lys Thr Gly His Pro Arg Thr 
                885                 890                 895     


Ser Met Leu Gln Lys Ser Leu Ser Val Ile Ala Ser Ala Lys Glu Lys 
            900                 905                 910         


Thr Leu Gly Leu Ala Gly Lys Thr Gln Thr Ala Gly Val Glu Glu Arg 
        915                 920                 925             


Thr Lys Ser Gln Lys Pro Leu Pro Lys Asp Lys Glu Thr Asn Arg Asn 
    930                 935                 940                 


His Ser Asn Ser Asp Asn Thr Glu Thr Lys Asp Pro Ala Pro Gln Asn 
945                 950                 955                 960 


Ser Asn Pro Ala Glu Glu Pro Arg Lys Pro Gln Lys Ser Gly Ile Met 
                965                 970                 975     


Lys Gln Gln Arg Val Asn Pro Thr Thr Ala Asn Ser Asp Leu Asn Pro 
            980                 985                 990         


Gly Thr Thr Gln Met Lys Asp Asn  Phe Asp Ile Gly Glu  Val Cys Pro 
        995                 1000                 1005             


Trp Glu  Val Tyr Asp Leu Thr  Pro Gly Pro Val Pro  Ser Glu Ser 
    1010                 1015                 1020             


Lys Val  Gln Lys His Val Ser  Ile Val Ala Ser Glu  Met Glu Lys 
    1025                 1030                 1035             


Asn Pro  Thr Phe Ser Leu Lys  Glu Lys Ser His His  Lys Pro Lys 
    1040                 1045                 1050             


Ala Ala  Glu Val Cys Gln Gln  Ser Asn Gln Lys Arg  Ile Asp Lys 
    1055                 1060                 1065             


Ala Glu  Val Cys Leu Trp Glu  Ser Gln Gly Gln Ser  Ile Leu Glu 
    1070                 1075                 1080             


Asp Glu  Lys Leu Leu Ile Ser  Lys Thr Pro Val Leu  Pro Glu Arg 
    1085                 1090                 1095             


Ala Lys  Glu Glu Asn Gly Gly  Gln Pro Arg Ala Ala  Asn Val Cys 
    1100                 1105                 1110             


Ala Gly  Gln Ser Glu Glu Leu  Pro Pro Lys Ala Val  Ala Ser Lys 
    1115                 1120                 1125             


Thr Glu  Asn Glu Asn Leu Asn  Gln Ile Gly His Gln  Glu Lys Lys 
    1130                 1135                 1140             


Thr Ser  Ser Ser Glu Glu Asn  Val Arg Gly Ser Tyr  Asn Ser Ser 
    1145                 1150                 1155             


Asn Asn  Phe Gln Gln Pro Leu  Thr Ser Arg Ala Glu  Val Cys Pro 
    1160                 1165                 1170             


Trp Glu  Phe Glu Thr Pro Ala  Gln Pro Asn Ala Gly  Arg Ser Val 
    1175                 1180                 1185             


Ala Leu  Pro Ala Ser Ser Ala  Leu Ser Ala Asn Lys  Ile Ala Gly 
    1190                 1195                 1200             


Pro Arg  Lys Glu Glu Ile Trp  Asp Ser Phe Lys Val  
    1205                 1210                 1215 


<210>  4717
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  4717

Met Gly Ser Val Leu Gly Leu Cys Ser Met Ala Ser Trp Ile Pro Cys 
1               5                   10                  15      


Leu Cys Gly Ser Ala Pro Cys Leu Leu Cys Arg Cys Cys Pro Ser Gly 
            20                  25                  30          


Asn Asn Ser Thr Val Thr Arg Leu Ile Tyr Ala Leu Phe Leu Leu Val 
        35                  40                  45              


Gly Val Cys Val Ala Cys Val Met Leu Ile Pro Gly Met Glu Glu Gln 
    50                  55                  60                  


Leu Asn Lys Ile Pro Gly Phe Cys Glu Asn Glu Lys Gly Val Val Pro 
65                  70                  75                  80  


Cys Asn Ile Leu Val Gly Tyr Lys Ala Val Tyr Arg Leu Cys Phe Gly 
                85                  90                  95      


Leu Ala Met Phe Tyr Leu Leu Leu Ser Leu Leu Met Ile Lys Val Lys 
            100                 105                 110         


Ser Ser Ser Asp Pro Arg Ala Ala Val His Asn Gly Phe Trp Phe Phe 
        115                 120                 125             


Lys Phe Ala Ala Ala Ile Ala Ile Ile Ile Gly Ala Phe Phe Ile Pro 
    130                 135                 140                 


Glu Gly Thr Phe Thr Thr Val Trp Phe Tyr Val Gly Met Ala Gly Ala 
145                 150                 155                 160 


Phe Cys Phe Ile Leu Ile Gln Leu Val Leu Leu Ile Asp Phe Ala His 
                165                 170                 175     


Ser Trp Asn Glu Ser Trp Val Glu Lys Met Glu Glu Gly Asn Ser Arg 
            180                 185                 190         


Cys Trp Tyr Ala Ala Leu Leu Ser Ala Thr Ala Leu Asn Tyr Leu Leu 
        195                 200                 205             


Ser Leu Val Ala Ile Val Leu Phe Phe Val Tyr Tyr Thr His Pro Ala 
    210                 215                 220                 


Ser Cys Ser Glu Asn Lys Ala Phe Ile Ser Val Asn Met Leu Leu Cys 
225                 230                 235                 240 


Val Gly Ala Ser Val Met Ser Ile Leu Pro Lys Ile Gln Glu Ser Gln 
                245                 250                 255     


Pro Arg Ser Gly Leu Leu Gln Ser Ser Val Ile Thr Val Tyr Thr Met 
            260                 265                 270         


Tyr Leu Thr Trp Ser Ala Met Thr Asn Glu Pro Glu Thr Asn Cys Asn 
        275                 280                 285             


Pro Ser Leu Leu Ser Ile Ile Gly Tyr Asn Thr Thr Ser Thr Val Pro 
    290                 295                 300                 


Lys Glu Gly Gln Ser Val Gln Trp Trp His Ala Gln Gly Ile Ile Gly 
305                 310                 315                 320 


Leu Ile Leu Phe Leu Leu Cys Val Phe Tyr Ser Ser Ile Arg Thr Ser 
                325                 330                 335     


Asn Asn Ser Gln Val Asn Lys Leu Thr Leu Thr Ser Asp Glu Ser Thr 
            340                 345                 350         


Leu Ile Glu Asp Gly Gly Ala Arg Ser Asp Gly Ser Leu Glu Asp Gly 
        355                 360                 365             


Asp Asp Val His Arg Ala Val Asp Asn Glu Arg Asp Gly Val Thr Tyr 
    370                 375                 380                 


Ser Tyr Ser Phe Phe His Phe Met Leu Phe Leu Ala Ser Leu Tyr Ile 
385                 390                 395                 400 


Met Met Thr Leu Thr Asn Trp Tyr Arg Tyr Glu Pro Ser Arg Glu Met 
                405                 410                 415     


Lys Ser Gln Trp Thr Ala Val Trp Val Lys Ile Ser Ser Ser Trp Ile 
            420                 425                 430         


Gly Ile Val Leu Tyr Val Trp Thr Leu Val Ala Pro Leu Val Leu Thr 
        435                 440                 445             


Asn Arg Asp Phe Asp 
    450             


<210>  4718
<211>  1100
<212>  PRT
<213>  Homo sapiens

<400>  4718

Met Glu Ser Leu Leu Leu Pro Val Leu Leu Leu Leu Ala Ile Leu Trp 
1               5                   10                  15      


Thr Gln Ala Ala Ala Leu Ile Asn Leu Lys Tyr Ser Val Glu Glu Glu 
            20                  25                  30          


Gln Arg Ala Gly Thr Val Ile Ala Asn Val Ala Lys Asp Ala Arg Glu 
        35                  40                  45              


Ala Gly Phe Ala Leu Asp Pro Arg Gln Ala Ser Ala Phe Arg Val Val 
    50                  55                  60                  


Ser Asn Ser Ala Pro His Leu Val Asp Ile Asn Pro Ser Ser Gly Leu 
65                  70                  75                  80  


Leu Val Thr Lys Gln Lys Ile Asp Arg Asp Leu Leu Cys Arg Gln Ser 
                85                  90                  95      


Pro Lys Cys Ile Ile Ser Leu Glu Val Met Ser Ser Ser Met Glu Ile 
            100                 105                 110         


Cys Val Ile Lys Val Glu Ile Lys Asp Leu Asn Asp Asn Ala Pro Ser 
        115                 120                 125             


Phe Pro Ala Ala Gln Ile Glu Leu Glu Ile Ser Glu Ala Ala Ser Pro 
    130                 135                 140                 


Gly Thr Arg Ile Pro Leu Asp Ser Ala Tyr Asp Pro Asp Ser Gly Ser 
145                 150                 155                 160 


Phe Gly Val Gln Thr Tyr Glu Leu Thr Pro Asn Glu Leu Phe Gly Leu 
                165                 170                 175     


Glu Ile Lys Thr Arg Gly Asp Gly Ser Arg Phe Ala Glu Leu Val Val 
            180                 185                 190         


Glu Lys Ser Leu Asp Arg Glu Thr Gln Ser His Tyr Ser Phe Arg Ile 
        195                 200                 205             


Thr Ala Leu Asp Gly Gly Asp Pro Pro Arg Leu Gly Thr Val Gly Leu 
    210                 215                 220                 


Ser Ile Lys Val Thr Asp Ser Asn Asp Asn Asn Pro Val Phe Ser Glu 
225                 230                 235                 240 


Ser Thr Tyr Ala Val Ser Val Pro Glu Asn Ser Pro Pro Asn Thr Pro 
                245                 250                 255     


Val Ile Arg Leu Asn Ala Ser Asp Pro Asp Glu Gly Thr Asn Gly Gln 
            260                 265                 270         


Val Val Tyr Ser Phe Tyr Gly Tyr Val Asn Asp Arg Thr Arg Glu Leu 
        275                 280                 285             


Phe Gln Ile Asp Pro His Ser Gly Leu Val Thr Val Thr Gly Ala Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Gly His Val Tyr Glu Leu Asp Val Gln Ala Lys Asp 
305                 310                 315                 320 


Leu Gly Pro Asn Ser Ile Pro Ala His Cys Lys Val Thr Val Ser Val 
                325                 330                 335     


Leu Asp Thr Asn Asp Asn Pro Pro Val Ile Asn Leu Leu Ser Val Asn 
            340                 345                 350         


Ser Glu Leu Val Glu Val Ser Glu Ser Ala Pro Pro Gly Tyr Val Ile 
        355                 360                 365             


Ala Leu Val Arg Val Ser Asp Arg Asp Ser Gly Leu Asn Gly Arg Val 
    370                 375                 380                 


Gln Cys Arg Leu Leu Gly Asn Val Pro Phe Arg Leu Gln Glu Tyr Glu 
385                 390                 395                 400 


Ser Phe Ser Thr Ile Leu Val Asp Gly Arg Leu Asp Arg Glu Gln His 
                405                 410                 415     


Asp Gln Tyr Asn Leu Thr Ile Gln Ala Arg Asp Gly Gly Val Pro Met 
            420                 425                 430         


Leu Gln Ser Ala Lys Ser Phe Thr Val Leu Ile Thr Asp Glu Asn Asp 
        435                 440                 445             


Asn His Pro His Phe Ser Lys Pro Tyr Tyr Gln Val Ile Val Gln Glu 
    450                 455                 460                 


Asn Asn Thr Pro Gly Ala Tyr Leu Leu Ser Val Ser Ala Arg Asp Pro 
465                 470                 475                 480 


Asp Leu Gly Leu Asn Gly Ser Val Ser Tyr Gln Ile Val Pro Ser Gln 
                485                 490                 495     


Val Arg Asp Met Pro Val Phe Thr Tyr Val Ser Ile Asn Pro Asn Ser 
            500                 505                 510         


Gly Asp Ile Tyr Ala Leu Arg Ser Phe Asn His Glu Gln Thr Lys Ala 
        515                 520                 525             


Phe Glu Phe Lys Val Leu Ala Lys Asp Gly Gly Leu Pro Ser Leu Gln 
    530                 535                 540                 


Ser Asn Ala Thr Val Arg Val Ile Ile Leu Asp Val Asn Asp Asn Thr 
545                 550                 555                 560 


Pro Val Ile Thr Ala Pro Pro Leu Ile Asn Gly Thr Ala Glu Val Tyr 
                565                 570                 575     


Ile Pro Arg Asn Ser Gly Ile Gly Tyr Leu Val Thr Val Val Lys Ala 
            580                 585                 590         


Glu Asp Tyr Asp Glu Gly Glu Asn Gly Arg Val Thr Tyr Asp Met Thr 
        595                 600                 605             


Glu Gly Asp Arg Gly Phe Phe Glu Ile Asp Gln Val Asn Gly Glu Val 
    610                 615                 620                 


Arg Thr Thr Arg Thr Phe Gly Glu Ser Ser Lys Ser Ser Tyr Glu Leu 
625                 630                 635                 640 


Ile Val Val Ala His Asp His Gly Lys Thr Ser Leu Ser Ala Ser Ala 
                645                 650                 655     


Leu Val Leu Ile Tyr Leu Ser Pro Ala Leu Asp Ala Gln Glu Ser Met 
            660                 665                 670         


Gly Ser Val Asn Leu Ser Leu Ile Phe Ile Ile Ala Leu Gly Ser Ile 
        675                 680                 685             


Ala Gly Ile Leu Phe Val Thr Met Ile Phe Val Ala Ile Lys Cys Lys 
    690                 695                 700                 


Arg Asp Asn Lys Glu Ile Arg Thr Tyr Asn Cys Arg Ile Ala Glu Tyr 
705                 710                 715                 720 


Ser Tyr Gly His Gln Lys Lys Ser Ser Lys Lys Lys Lys Ile Ser Lys 
                725                 730                 735     


Asn Asp Ile Arg Leu Val Pro Arg Asp Val Glu Glu Thr Asp Lys Met 
            740                 745                 750         


Asn Val Val Ser Cys Ser Ser Leu Thr Ser Ser Leu Asn Tyr Phe Asp 
        755                 760                 765             


Tyr His Gln Gln Thr Leu Pro Leu Gly Cys Arg Arg Ser Glu Ser Thr 
    770                 775                 780                 


Phe Leu Asn Val Glu Asn Gln Asn Thr Arg Asn Thr Ser Ala Asn His 
785                 790                 795                 800 


Ile Tyr His His Ser Phe Asn Ser Gln Gly Pro Gln Gln Pro Asp Leu 
                805                 810                 815     


Ile Ile Asn Gly Val Pro Leu Pro Glu Thr Glu Asn Tyr Ser Phe Asp 
            820                 825                 830         


Ser Asn Tyr Val Asn Ser Arg Ala His Leu Ile Lys Ser Ser Thr Phe 
        835                 840                 845             


Lys Asp Leu Glu Gly Asn Ser Leu Lys Asp Ser Gly His Glu Glu Ser 
    850                 855                 860                 


Asp Gln Thr Asp Ser Glu His Asp Val Gln Arg Ser Leu Tyr Cys Asp 
865                 870                 875                 880 


Thr Ala Val Asn Asp Val Leu Asn Thr Ser Val Thr Ser Met Gly Ser 
                885                 890                 895     


Gln Met Pro Asp His Asp Gln Asn Glu Gly Phe His Cys Arg Glu Glu 
            900                 905                 910         


Cys Arg Ile Leu Gly His Ser Asp Arg Cys Trp Met Pro Arg Asn Pro 
        915                 920                 925             


Met Pro Ile Arg Ser Lys Ser Pro Glu His Val Arg Asn Ile Ile Ala 
    930                 935                 940                 


Leu Ser Ile Glu Ala Thr Ala Ala Asp Val Glu Ala Tyr Asp Asp Cys 
945                 950                 955                 960 


Gly Pro Thr Lys Arg Thr Phe Ala Thr Phe Gly Lys Asp Val Ser Asp 
                965                 970                 975     


His Pro Ala Glu Glu Arg Pro Thr Leu Lys Gly Lys Arg Thr Val Asp 
            980                 985                 990         


Val Thr Ile Cys Ser Pro Lys Val  Asn Ser Val Ile Arg  Glu Ala Gly 
        995                 1000                 1005             


Asn Gly  Cys Glu Ala Ile Ser  Pro Val Thr Ser Pro  Leu His Leu 
    1010                 1015                 1020             


Lys Ser  Ser Leu Pro Thr Lys  Pro Ser Val Ser Tyr  Thr Ile Ala 
    1025                 1030                 1035             


Leu Ala  Pro Pro Ala Arg Asp  Leu Glu Gln Tyr Val  Asn Asn Val 
    1040                 1045                 1050             


Asn Asn  Gly Pro Thr Arg Pro  Ser Glu Ala Glu Pro  Arg Gly Ala 
    1055                 1060                 1065             


Asp Ser  Glu Lys Val Met His  Glu Val Ser Pro Ile  Leu Lys Glu 
    1070                 1075                 1080             


Gly Arg  Asn Lys Glu Ser Pro  Gly Val Lys Arg Leu  Lys Asp Ile 
    1085                 1090                 1095             


Val Leu  
    1100 


<210>  4719
<211>  1013
<212>  PRT
<213>  Homo sapiens

<400>  4719

Met Ala Glu Pro Gly His Ser His His Leu Ser Ala Arg Val Arg Gly 
1               5                   10                  15      


Arg Thr Glu Arg Arg Ile Pro Arg Leu Trp Arg Leu Leu Leu Trp Ala 
            20                  25                  30          


Gly Thr Ala Phe Gln Val Thr Gln Gly Thr Gly Pro Glu Leu His Ala 
        35                  40                  45              


Cys Lys Glu Ser Glu Tyr His Tyr Glu Tyr Thr Ala Cys Asp Ser Thr 
    50                  55                  60                  


Gly Ser Arg Trp Arg Val Ala Val Pro His Thr Pro Gly Leu Cys Thr 
65                  70                  75                  80  


Ser Leu Pro Asp Pro Val Lys Gly Thr Glu Cys Ser Phe Ser Cys Asn 
                85                  90                  95      


Ala Gly Glu Phe Leu Asp Met Lys Asp Gln Ser Cys Lys Pro Cys Ala 
            100                 105                 110         


Glu Gly Arg Tyr Ser Leu Gly Thr Gly Ile Arg Phe Asp Glu Trp Asp 
        115                 120                 125             


Glu Leu Pro His Gly Phe Ala Ser Leu Ser Ala Asn Met Glu Leu Asp 
    130                 135                 140                 


Asp Ser Ala Ala Glu Ser Thr Gly Asn Cys Thr Ser Ser Lys Trp Val 
145                 150                 155                 160 


Pro Arg Gly Asp Tyr Ile Ala Ser Asn Thr Asp Glu Cys Thr Ala Thr 
                165                 170                 175     


Leu Met Tyr Ala Val Asn Leu Lys Gln Ser Gly Thr Val Asn Phe Glu 
            180                 185                 190         


Tyr Tyr Tyr Pro Asp Ser Ser Ile Ile Phe Glu Phe Phe Val Gln Asn 
        195                 200                 205             


Asp Gln Cys Gln Pro Asn Ala Asp Asp Ser Arg Trp Met Lys Thr Thr 
    210                 215                 220                 


Glu Lys Gly Trp Glu Phe His Ser Val Glu Leu Asn Arg Gly Asn Asn 
225                 230                 235                 240 


Val Leu Tyr Trp Arg Thr Thr Ala Phe Ser Val Trp Thr Lys Val Pro 
                245                 250                 255     


Lys Pro Val Leu Val Arg Asn Ile Ala Ile Thr Gly Val Ala Tyr Thr 
            260                 265                 270         


Ser Glu Cys Phe Pro Cys Lys Pro Gly Thr Tyr Ala Asp Lys Gln Gly 
        275                 280                 285             


Ser Ser Phe Cys Lys Leu Cys Pro Ala Asn Ser Tyr Ser Asn Lys Gly 
    290                 295                 300                 


Glu Thr Ser Cys His Gln Cys Asp Pro Asp Lys Tyr Ser Glu Lys Gly 
305                 310                 315                 320 


Ser Ser Ser Cys Asn Val Arg Pro Ala Cys Thr Asp Lys Asp Tyr Phe 
                325                 330                 335     


Tyr Thr His Thr Ala Cys Asp Ala Asn Gly Glu Thr Gln Leu Met Tyr 
            340                 345                 350         


Lys Trp Ala Lys Pro Lys Ile Cys Ser Glu Asp Leu Glu Gly Ala Val 
        355                 360                 365             


Lys Leu Pro Ala Ser Gly Val Lys Thr His Cys Pro Pro Cys Asn Pro 
    370                 375                 380                 


Gly Phe Phe Lys Thr Asn Asn Ser Thr Cys Gln Pro Cys Pro Tyr Gly 
385                 390                 395                 400 


Ser Tyr Ser Asn Gly Ser Asp Cys Thr Arg Cys Pro Ala Gly Thr Glu 
                405                 410                 415     


Pro Ala Val Gly Phe Glu Tyr Lys Trp Trp Asn Thr Leu Pro Thr Asn 
            420                 425                 430         


Met Glu Thr Thr Val Leu Ser Gly Ile Asn Phe Glu Tyr Lys Gly Met 
        435                 440                 445             


Thr Gly Trp Glu Val Ala Gly Asp His Ile Tyr Thr Ala Ala Gly Ala 
    450                 455                 460                 


Ser Asp Asn Asp Phe Met Ile Leu Thr Leu Val Val Pro Gly Phe Arg 
465                 470                 475                 480 


Pro Pro Gln Ser Val Met Ala Asp Thr Glu Asn Lys Glu Val Ala Arg 
                485                 490                 495     


Ile Thr Phe Val Phe Glu Thr Leu Cys Ser Val Asn Cys Glu Leu Tyr 
            500                 505                 510         


Phe Met Val Gly Val Asn Ser Arg Thr Asn Thr Pro Val Glu Thr Trp 
        515                 520                 525             


Lys Gly Ser Lys Gly Lys Gln Ser Tyr Thr Tyr Ile Ile Glu Glu Asn 
    530                 535                 540                 


Thr Thr Thr Ser Phe Thr Trp Ala Phe Gln Arg Thr Thr Phe His Glu 
545                 550                 555                 560 


Ala Ser Arg Lys Tyr Thr Asn Asp Val Ala Lys Ile Tyr Ser Ile Asn 
                565                 570                 575     


Val Thr Asn Val Met Asn Gly Val Ala Ser Tyr Cys Arg Pro Cys Ala 
            580                 585                 590         


Leu Glu Ala Ser Asp Val Gly Ser Ser Cys Thr Ser Cys Pro Ala Gly 
        595                 600                 605             


Tyr Tyr Ile Asp Arg Asp Ser Gly Thr Cys His Ser Cys Pro Thr Asn 
    610                 615                 620                 


Thr Ile Leu Lys Ala His Gln Pro Tyr Gly Val Gln Ala Cys Val Pro 
625                 630                 635                 640 


Cys Gly Pro Gly Thr Lys Asn Asn Lys Ile His Ser Leu Cys Tyr Asn 
                645                 650                 655     


Asp Cys Thr Phe Ser Arg Asn Thr Pro Thr Arg Thr Phe Asn Tyr Asn 
            660                 665                 670         


Phe Ser Ala Leu Ala Asn Thr Val Thr Leu Ala Gly Gly Pro Ser Phe 
        675                 680                 685             


Thr Ser Lys Gly Leu Lys Tyr Phe His His Phe Thr Leu Ser Leu Cys 
    690                 695                 700                 


Gly Asn Gln Gly Arg Lys Met Ser Val Cys Thr Asp Asn Val Thr Asp 
705                 710                 715                 720 


Leu Arg Ile Pro Glu Gly Glu Ser Gly Phe Ser Lys Ser Ile Thr Ala 
                725                 730                 735     


Tyr Val Cys Gln Ala Val Ile Ile Pro Pro Glu Val Thr Gly Tyr Lys 
            740                 745                 750         


Ala Gly Val Ser Ser Gln Pro Val Ser Leu Ala Asp Arg Leu Ile Gly 
        755                 760                 765             


Val Thr Thr Asp Met Thr Leu Asp Gly Ile Thr Ser Pro Ala Glu Leu 
    770                 775                 780                 


Phe His Leu Glu Ser Leu Gly Ile Pro Asp Val Ile Phe Phe Tyr Arg 
785                 790                 795                 800 


Ser Asn Asp Val Thr Gln Ser Cys Ser Ser Gly Arg Ser Thr Thr Ile 
                805                 810                 815     


Arg Val Arg Cys Ser Pro Gln Lys Thr Val Pro Gly Ser Leu Leu Leu 
            820                 825                 830         


Pro Gly Thr Cys Ser Asp Gly Thr Cys Asp Gly Cys Asn Phe His Phe 
        835                 840                 845             


Leu Trp Glu Ser Ala Ala Ala Cys Pro Leu Cys Ser Val Ala Asp Tyr 
    850                 855                 860                 


His Ala Ile Val Ser Ser Cys Val Ala Gly Ile Gln Lys Thr Thr Tyr 
865                 870                 875                 880 


Val Trp Arg Glu Pro Lys Leu Cys Ser Gly Gly Ile Ser Leu Pro Glu 
                885                 890                 895     


Gln Arg Val Thr Ile Cys Lys Thr Ile Asp Phe Trp Leu Lys Val Gly 
            900                 905                 910         


Ile Ser Ala Gly Thr Cys Thr Ala Ile Leu Leu Thr Val Leu Thr Cys 
        915                 920                 925             


Tyr Phe Trp Lys Lys Asn Gln Lys Leu Glu Tyr Lys Tyr Ser Lys Leu 
    930                 935                 940                 


Val Met Asn Ala Thr Leu Lys Asp Cys Asp Leu Pro Ala Ala Asp Ser 
945                 950                 955                 960 


Cys Ala Ile Met Glu Gly Glu Asp Val Glu Asp Asp Leu Ile Phe Thr 
                965                 970                 975     


Ser Lys Lys Ser Leu Phe Gly Lys Ile Lys Ser Phe Thr Ser Lys Arg 
            980                 985                 990         


Thr Pro Asp Gly Phe Asp Ser Val  Pro Leu Lys Thr Ser  Ser Gly Gly 
        995                 1000                 1005             


Leu Asp  Met Asp Leu 
    1010             


<210>  4720
<211>  1159
<212>  PRT
<213>  Homo sapiens

<400>  4720

Met Ala His Arg Gly Pro Ser Arg Ala Ser Lys Gly Pro Gly Pro Thr 
1               5                   10                  15      


Ala Arg Ala Pro Ser Pro Gly Ala Pro Pro Pro Pro Arg Ser Pro Arg 
            20                  25                  30          


Ser Arg Pro Leu Leu Leu Leu Leu Leu Leu Leu Gly Ala Cys Gly Ala 
        35                  40                  45              


Ala Gly Arg Ser Pro Glu Pro Gly Arg Leu Gly Pro His Ala Gln Leu 
    50                  55                  60                  


Thr Arg Val Pro Arg Ser Pro Pro Ala Gly Arg Ala Glu Pro Gly Gly 
65                  70                  75                  80  


Gly Glu Asp Arg Gln Ala Arg Gly Thr Glu Pro Gly Ala Pro Gly Pro 
                85                  90                  95      


Ser Pro Gly Pro Ala Pro Gly Pro Gly Glu Asp Gly Ala Pro Ala Ala 
            100                 105                 110         


Gly Tyr Arg Arg Trp Glu Arg Ala Ala Pro Leu Ala Gly Val Ala Ser 
        115                 120                 125             


Arg Ala Gln Val Ser Leu Ile Ser Thr Ser Phe Val Leu Lys Gly Asp 
    130                 135                 140                 


Ala Thr His Asn Gln Ala Met Val His Trp Thr Gly Glu Asn Ser Ser 
145                 150                 155                 160 


Val Ile Leu Ile Leu Thr Lys Tyr Tyr His Ala Asp Met Gly Lys Val 
                165                 170                 175     


Leu Glu Ser Ser Leu Trp Arg Ser Ser Asp Phe Gly Thr Ser Tyr Thr 
            180                 185                 190         


Lys Leu Thr Leu Gln Pro Gly Val Thr Thr Val Ile Asp Asn Phe Tyr 
        195                 200                 205             


Ile Cys Pro Thr Asn Lys Arg Lys Val Ile Leu Val Ser Ser Ser Leu 
    210                 215                 220                 


Ser Asp Arg Asp Gln Ser Leu Phe Leu Ser Ala Asp Glu Gly Ala Thr 
225                 230                 235                 240 


Phe Gln Lys Gln Pro Ile Pro Phe Phe Val Glu Thr Leu Ile Phe His 
                245                 250                 255     


Pro Lys Glu Glu Asp Lys Val Leu Ala Tyr Thr Lys Glu Ser Lys Leu 
            260                 265                 270         


Tyr Val Ser Ser Asp Leu Gly Lys Lys Trp Thr Leu Leu Gln Glu Arg 
        275                 280                 285             


Val Thr Lys Asp His Val Phe Trp Ser Val Ser Gly Val Asp Ala Asp 
    290                 295                 300                 


Pro Asp Leu Val His Val Glu Ala Gln Asp Leu Gly Gly Asp Phe Arg 
305                 310                 315                 320 


Tyr Val Thr Cys Ala Ile His Asn Cys Ser Glu Lys Met Leu Thr Ala 
                325                 330                 335     


Pro Phe Ala Gly Pro Ile Asp His Gly Ser Leu Thr Val Gln Asp Asp 
            340                 345                 350         


Tyr Ile Phe Phe Lys Ala Thr Ser Ala Asn Gln Thr Lys Tyr Tyr Val 
        355                 360                 365             


Ser Tyr Arg Arg Asn Glu Phe Val Leu Met Lys Leu Pro Lys Tyr Ala 
    370                 375                 380                 


Leu Pro Lys Asp Leu Gln Ile Ile Ser Thr Asp Glu Ser Gln Val Phe 
385                 390                 395                 400 


Val Ala Val Gln Glu Trp Tyr Gln Met Asp Thr Tyr Asn Leu Tyr Gln 
                405                 410                 415     


Ser Asp Pro Arg Gly Val Arg Tyr Ala Leu Val Leu Gln Asp Val Arg 
            420                 425                 430         


Ser Ser Arg Gln Ala Glu Glu Ser Val Leu Ile Asp Ile Leu Glu Val 
        435                 440                 445             


Arg Gly Val Lys Gly Val Phe Leu Ala Asn Gln Lys Ile Asp Gly Lys 
    450                 455                 460                 


Val Met Thr Leu Ile Thr Tyr Asn Lys Gly Arg Asp Trp Asp Tyr Leu 
465                 470                 475                 480 


Arg Pro Pro Ser Met Asp Met Asn Gly Lys Pro Thr Asn Cys Lys Pro 
                485                 490                 495     


Pro Asp Cys His Leu His Leu His Leu Arg Trp Ala Asp Asn Pro Tyr 
            500                 505                 510         


Val Ser Gly Thr Val His Thr Lys Asp Thr Ala Pro Gly Leu Ile Met 
        515                 520                 525             


Gly Ala Gly Asn Leu Gly Ser Gln Leu Val Glu Tyr Lys Glu Glu Met 
    530                 535                 540                 


Tyr Ile Thr Ser Asp Cys Gly His Thr Trp Arg Gln Val Phe Glu Glu 
545                 550                 555                 560 


Glu His His Ile Leu Tyr Leu Asp His Gly Gly Val Ile Val Ala Ile 
                565                 570                 575     


Lys Asp Thr Ser Ile Pro Leu Lys Ile Leu Lys Phe Ser Val Asp Glu 
            580                 585                 590         


Gly Leu Thr Trp Ser Thr His Asn Phe Thr Ser Thr Ser Val Phe Val 
        595                 600                 605             


Asp Gly Leu Leu Ser Glu Pro Gly Asp Glu Thr Leu Val Met Thr Val 
    610                 615                 620                 


Phe Gly His Ile Ser Phe Arg Ser Asp Trp Glu Leu Val Lys Val Asp 
625                 630                 635                 640 


Phe Arg Pro Ser Phe Ser Arg Gln Cys Gly Glu Glu Asp Tyr Ser Ser 
                645                 650                 655     


Trp Glu Leu Ser Asn Leu Gln Gly Asp Arg Cys Ile Met Gly Gln Gln 
            660                 665                 670         


Arg Ser Phe Arg Lys Arg Lys Ser Thr Ser Trp Cys Ile Lys Gly Arg 
        675                 680                 685             


Ser Phe Thr Ser Ala Leu Thr Ser Arg Val Cys Glu Cys Arg Asp Ser 
    690                 695                 700                 


Asp Phe Leu Cys Asp Tyr Gly Phe Glu Arg Ser Ser Ser Ser Glu Ser 
705                 710                 715                 720 


Ser Thr Asn Lys Cys Ser Ala Asn Phe Trp Phe Asn Pro Leu Ser Pro 
                725                 730                 735     


Pro Asp Asp Cys Ala Leu Gly Gln Thr Tyr Thr Ser Ser Leu Gly Tyr 
            740                 745                 750         


Arg Lys Val Val Ser Asn Val Cys Glu Gly Gly Val Asp Met Gln Gln 
        755                 760                 765             


Ser Gln Val Gln Leu Gln Cys Pro Leu Thr Pro Pro Arg Gly Leu Gln 
    770                 775                 780                 


Val Ser Ile Gln Gly Glu Ala Val Ala Val Arg Pro Gly Glu Asp Val 
785                 790                 795                 800 


Leu Phe Val Val Arg Gln Glu Gln Gly Asp Val Leu Thr Thr Lys Tyr 
                805                 810                 815     


Gln Val Asp Leu Gly Asp Gly Phe Lys Ala Met Tyr Val Asn Leu Thr 
            820                 825                 830         


Leu Thr Gly Glu Pro Ile Arg His Arg Tyr Glu Ser Pro Gly Ile Tyr 
        835                 840                 845             


Arg Val Ser Val Arg Ala Glu Asn Thr Ala Gly His Asp Glu Ala Val 
    850                 855                 860                 


Leu Phe Val Gln Val Asn Ser Pro Leu Gln Ala Leu Tyr Leu Glu Val 
865                 870                 875                 880 


Val Pro Val Ile Gly Leu Asn Gln Glu Val Asn Leu Thr Ala Val Leu 
                885                 890                 895     


Leu Pro Leu Asn Pro Asn Leu Thr Val Phe Tyr Trp Trp Ile Gly His 
            900                 905                 910         


Ser Leu Gln Pro Leu Leu Ser Leu Asp Asn Ser Val Thr Thr Arg Phe 
        915                 920                 925             


Ser Asp Thr Gly Asp Val Arg Val Thr Val Gln Ala Ala Cys Gly Asn 
    930                 935                 940                 


Ser Val Leu Gln Asp Ser Arg Val Leu Arg Val Leu Asp Gln Phe Gln 
945                 950                 955                 960 


Val Met Pro Leu Gln Phe Ser Lys Glu Leu Asp Ala Tyr Asn Pro Asn 
                965                 970                 975     


Thr Pro Glu Trp Arg Glu Asp Val Gly Leu Val Val Thr Arg Leu Leu 
            980                 985                 990         


Ser Lys Glu Thr Ser Val Pro Gln  Glu Leu Leu Val Thr  Val Val Lys 
        995                 1000                 1005             


Pro Gly  Leu Pro Thr Leu Ala  Asp Leu Tyr Val Leu  Leu Pro Pro 
    1010                 1015                 1020             


Pro Arg  Pro Thr Arg Lys Arg  Ser Leu Ser Ser Asp  Lys Arg Leu 
    1025                 1030                 1035             


Ala Ala  Ile Gln Gln Val Leu  Asn Ala Gln Lys Ile  Ser Phe Leu 
    1040                 1045                 1050             


Leu Arg  Gly Gly Val Arg Val  Leu Val Ala Leu Arg  Asp Thr Gly 
    1055                 1060                 1065             


Thr Gly  Ala Glu Gln Leu Gly  Gly Gly Gly Gly Tyr  Trp Ala Val 
    1070                 1075                 1080             


Val Val  Leu Phe Val Ile Gly  Leu Phe Ala Ala Gly  Ala Phe Ile 
    1085                 1090                 1095             


Leu Tyr  Lys Phe Lys Arg Lys  Arg Pro Gly Arg Thr  Val Tyr Ala 
    1100                 1105                 1110             


Gln Met  His Asn Glu Lys Glu  Gln Glu Met Thr Ser  Pro Val Ser 
    1115                 1120                 1125             


His Ser  Glu Asp Val Gln Gly  Ala Val Gln Gly Asn  His Ser Gly 
    1130                 1135                 1140             


Val Val  Leu Ser Ile Asn Ser  Arg Glu Met His Ser  Tyr Leu Val 
    1145                 1150                 1155             


Ser 
    


<210>  4721
<211>  1392
<212>  PRT
<213>  Homo sapiens

<400>  4721

Met Asp Thr Glu Asp Asp Pro Leu Leu Gln Asp Val Trp Leu Glu Glu 
1               5                   10                  15      


Glu Gln Glu Glu Glu Glu Ala Thr Gly Glu Thr Phe Leu Gly Ala Gln 
            20                  25                  30          


Lys Pro Gly Pro Gln Pro Gly Ala Gly Gly Gln Cys Cys Trp Arg His 
        35                  40                  45              


Trp Pro Leu Ala Ser Arg Pro Pro Ala Ser Gly Phe Trp Ser Thr Leu 
    50                  55                  60                  


Gly Trp Ala Phe Thr Asn Pro Cys Cys Ala Gly Leu Val Leu Phe Leu 
65                  70                  75                  80  


Gly Cys Ser Ile Pro Met Ala Leu Ser Ala Phe Met Phe Leu Tyr Tyr 
                85                  90                  95      


Pro Pro Leu Asp Ile Asp Ile Ser Tyr Asn Ala Phe Glu Ile Arg Asn 
            100                 105                 110         


His Glu Ala Ser Gln Arg Phe Asp Ala Leu Thr Leu Ala Leu Lys Ser 
        115                 120                 125             


Gln Phe Gly Ser Trp Gly Arg Asn Arg Arg Asp Leu Ala Asp Phe Thr 
    130                 135                 140                 


Ser Glu Thr Leu Gln Arg Leu Ile Ser Glu Gln Leu Gln Gln Leu His 
145                 150                 155                 160 


Leu Gly Asn Arg Ser Arg Gln Ala Ser Arg Ala Pro Arg Val Ile Pro 
                165                 170                 175     


Ala Ala Ser Leu Gly Gly Pro Gly Pro Tyr Arg Asp Thr Ser Ala Ala 
            180                 185                 190         


Gln Lys Pro Thr Ala Asn Arg Ser Gly Arg Leu Arg Arg Glu Thr Pro 
        195                 200                 205             


Pro Leu Glu Asp Leu Ala Ala Asn Gln Ser Glu Asp Pro Arg Asn Gln 
    210                 215                 220                 


Arg Leu Ser Lys Asn Gly Arg Tyr Gln Pro Ser Ile Pro Pro His Ala 
225                 230                 235                 240 


Ala Val Ala Ala Asn Gln Ser Arg Ala Arg Arg Gly Ala Ser Arg Trp 
                245                 250                 255     


Asp Tyr Ser Arg Ala Tyr Val Ser Ala Asn Thr Gln Thr His Ala His 
            260                 265                 270         


Trp Arg Ile Glu Leu Ile Phe Leu Ala Arg Gly Asp Ala Glu Arg Asn 
        275                 280                 285             


Ile Phe Thr Ser Glu Arg Leu Val Thr Ile His Glu Ile Glu Arg Lys 
    290                 295                 300                 


Ile Met Asp His Pro Gly Phe Arg Glu Phe Cys Trp Lys Pro His Glu 
305                 310                 315                 320 


Val Leu Lys Asp Leu Pro Leu Gly Ser Tyr Ser Tyr Cys Ser Pro Pro 
                325                 330                 335     


Ser Ser Leu Met Thr Tyr Phe Phe Pro Thr Glu Arg Gly Gly Lys Ile 
            340                 345                 350         


Tyr Tyr Asp Gly Met Gly Gln Asp Leu Ala Asp Ile Arg Gly Ser Leu 
        355                 360                 365             


Glu Leu Ala Met Thr His Pro Glu Phe Tyr Trp Tyr Val Asp Glu Gly 
    370                 375                 380                 


Leu Ser Ala Asp Asn Leu Lys Ser Ser Leu Leu Arg Ser Glu Ile Leu 
385                 390                 395                 400 


Phe Gly Ala Pro Leu Pro Asn Tyr Tyr Ser Val Asp Asp Arg Trp Glu 
                405                 410                 415     


Glu Gln Arg Ala Lys Phe Gln Ser Phe Val Val Thr Tyr Val Ala Met 
            420                 425                 430         


Leu Ala Lys Gln Ser Thr Ser Lys Val Gln Val Leu Tyr Gly Gly Thr 
        435                 440                 445             


Asp Leu Phe Asp Tyr Glu Val Arg Arg Thr Phe Asn Asn Asp Met Leu 
    450                 455                 460                 


Leu Ala Phe Ile Ser Ser Ser Cys Ile Ala Ala Leu Val Tyr Ile Leu 
465                 470                 475                 480 


Thr Ser Cys Ser Val Phe Leu Ser Phe Phe Gly Ile Ala Ser Ile Gly 
                485                 490                 495     


Leu Ser Cys Leu Val Ala Leu Phe Leu Tyr His Val Val Phe Gly Ile 
            500                 505                 510         


Gln Tyr Leu Gly Ile Leu Asn Gly Val Ala Ala Phe Val Ile Val Gly 
        515                 520                 525             


Ile Gly Val Asp Asp Val Phe Val Phe Ile Asn Thr Tyr Arg Gln Ala 
    530                 535                 540                 


Thr His Leu Glu Asp Pro Gln Leu Arg Met Ile His Thr Val Gln Thr 
545                 550                 555                 560 


Ala Gly Lys Ala Thr Phe Phe Thr Ser Leu Thr Thr Ala Ala Ala Tyr 
                565                 570                 575     


Ala Ala Asn Val Phe Ser Gln Ile Pro Ala Val His Asp Phe Gly Leu 
            580                 585                 590         


Phe Met Ser Leu Ile Val Ser Cys Cys Trp Leu Ala Val Leu Val Thr 
        595                 600                 605             


Met Pro Ala Ala Leu Gly Leu Trp Ser Leu Tyr Leu Ala Pro Leu Glu 
    610                 615                 620                 


Ser Ser Cys Gln Thr Ser Cys His Gln Asn Cys Ser Arg Lys Thr Ser 
625                 630                 635                 640 


Leu His Phe Pro Gly Asp Val Phe Ala Ala Pro Glu Gln Val Gly Gly 
                645                 650                 655     


Ser Pro Ala Gln Gly Pro Ile Pro Tyr Leu Asp Asp Asp Ile Pro Leu 
            660                 665                 670         


Leu Glu Val Glu Glu Glu Pro Val Ser Leu Glu Leu Gly Asp Val Ser 
        675                 680                 685             


Leu Val Ser Val Ser Pro Glu Gly Leu Gln Pro Ala Ser Asn Thr Gly 
    690                 695                 700                 


Ser Arg Gly His Leu Ile Val Gln Leu Gln Glu Leu Leu His His Trp 
705                 710                 715                 720 


Val Leu Trp Ser Ala Val Lys Ser Arg Trp Val Ile Val Gly Leu Phe 
                725                 730                 735     


Val Ser Ile Leu Ile Leu Ser Leu Val Phe Ala Ser Arg Leu Arg Pro 
            740                 745                 750         


Ala Ser Arg Ala Pro Leu Leu Phe Arg Pro Asp Thr Asn Ile Gln Val 
        755                 760                 765             


Leu Leu Asp Leu Lys Tyr Asn Leu Ser Ala Glu Gly Ile Ser Cys Ile 
    770                 775                 780                 


Thr Cys Ser Gly Leu Phe Gln Glu Lys Pro His Ser Leu Gln Asn Asn 
785                 790                 795                 800 


Ile Arg Thr Ser Leu Glu Lys Lys Arg Arg Gly Ser Gly Val Pro Trp 
                805                 810                 815     


Ala Ser Arg Pro Glu Ala Thr Leu Gln Asp Phe Pro Gly Thr Val Tyr 
            820                 825                 830         


Ile Ser Lys Val Lys Ser Gln Gly His Pro Ala Val Tyr Arg Leu Ser 
        835                 840                 845             


Leu Asn Ala Ser Leu Pro Ala Pro Trp Gln Ala Val Ser Pro Gly Asp 
    850                 855                 860                 


Gly Glu Val Pro Ser Phe Gln Val Tyr Arg Ala Pro Phe Gly Asn Phe 
865                 870                 875                 880 


Thr Lys Lys Leu Thr Ala Cys Met Ser Thr Val Gly Leu Leu Gln Ala 
                885                 890                 895     


Ala Ser Pro Ser Arg Lys Trp Met Leu Thr Thr Leu Ala Cys Asp Ala 
            900                 905                 910         


Lys Arg Gly Trp Lys Phe Asp Phe Ser Phe Tyr Val Ala Thr Lys Glu 
        915                 920                 925             


Gln Gln His Thr Arg Lys Leu Tyr Phe Ala Gln Ser His Lys Pro Pro 
    930                 935                 940                 


Phe His Gly Arg Val Cys Met Ala Pro Pro Gly Cys Leu Leu Ser Ser 
945                 950                 955                 960 


Ser Pro Asp Gly Pro Thr Lys Gly Phe Phe Phe Val Pro Ser Glu Lys 
                965                 970                 975     


Val Pro Lys Ala Arg Leu Ser Ala Thr Phe Gly Phe Asn Pro Cys Val 
            980                 985                 990         


Asn Thr Gly Cys Gly Lys Pro Ala  Val Arg Pro Leu Val  Asp Thr Gly 
        995                 1000                 1005             


Ala Met  Val Phe Val Val Phe  Gly Ile Ile Gly Val  Asn Arg Thr 
    1010                 1015                 1020             


Arg Gln  Val Asp Asn His Val  Ile Gly Asp Pro Gly  Ser Val Val 
    1025                 1030                 1035             


Tyr Asp  Ser Ser Phe Asp Leu  Phe Lys Glu Ile Gly  His Leu Cys 
    1040                 1045                 1050             


His Leu  Cys Lys Ala Ile Ala  Ala Asn Ser Glu Leu  Val Lys Pro 
    1055                 1060                 1065             


Gly Gly  Ala Gln Cys Leu Pro  Ser Gly Tyr Ser Ile  Ser Ser Phe 
    1070                 1075                 1080             


Leu Gln  Met Leu His Pro Glu  Cys Lys Glu Leu Pro  Glu Pro Asn 
    1085                 1090                 1095             


Leu Leu  Pro Gly Gln Leu Ser  His Gly Ala Val Gly  Val Arg Glu 
    1100                 1105                 1110             


Gly Arg  Val Gln Trp Ile Ser  Met Ala Phe Glu Ser  Thr Thr Tyr 
    1115                 1120                 1125             


Lys Gly  Lys Ser Ser Phe Gln  Thr Tyr Ser Asp Tyr  Leu Arg Trp 
    1130                 1135                 1140             


Glu Ser  Phe Leu Gln Gln Gln  Leu Gln Ala Leu Pro  Glu Gly Ser 
    1145                 1150                 1155             


Val Leu  Arg Arg Gly Phe Gln  Thr Cys Glu His Trp  Lys Gln Ile 
    1160                 1165                 1170             


Phe Met  Glu Ile Val Gly Val  Gln Ser Ala Leu Cys  Gly Leu Val 
    1175                 1180                 1185             


Leu Ser  Leu Leu Ile Cys Val  Ala Ala Val Ala Val  Phe Thr Thr 
    1190                 1195                 1200             


His Ile  Leu Leu Leu Leu Pro  Val Leu Leu Ser Ile  Leu Gly Ile 
    1205                 1210                 1215             


Val Cys  Leu Val Val Thr Ile  Met Tyr Trp Ser Gly  Trp Glu Met 
    1220                 1225                 1230             


Gly Ala  Val Glu Ala Ile Ser  Leu Ser Ile Leu Val  Gly Ser Ser 
    1235                 1240                 1245             


Val Asp  Tyr Cys Val His Leu  Val Glu Gly Tyr Leu  Leu Ala Gly 
    1250                 1255                 1260             


Glu Asn  Leu Pro Pro His Gln  Ala Glu Asp Ala Arg  Thr Gln Arg 
    1265                 1270                 1275             


Gln Trp  Arg Thr Leu Glu Ala  Val Arg His Val Gly  Val Ala Ile 
    1280                 1285                 1290             


Val Ser  Ser Ala Leu Thr Thr  Val Ile Ala Thr Val  Pro Leu Phe 
    1295                 1300                 1305             


Phe Cys  Ile Ile Ala Pro Phe  Ala Lys Phe Gly Lys  Ile Val Ala 
    1310                 1315                 1320             


Leu Asn  Thr Gly Val Ser Ile  Leu Tyr Thr Leu Thr  Val Ser Thr 
    1325                 1330                 1335             


Ala Leu  Leu Gly Ile Met Ala  Pro Ser Ser Phe Thr  Arg Thr Arg 
    1340                 1345                 1350             


Thr Ser  Phe Leu Lys Ala Leu  Gly Ala Val Leu Leu  Ala Gly Ala 
    1355                 1360                 1365             


Leu Gly  Leu Gly Ala Cys Leu  Val Leu Leu Gln Ser  Gly Tyr Lys 
    1370                 1375                 1380             


Ile Pro  Leu Pro Ala Gly Ala  Ser Leu 
    1385                 1390         


<210>  4722
<211>  425
<212>  PRT
<213>  Homo sapiens

<400>  4722

Met Ala Pro Ile Thr Thr Ser Arg Glu Glu Phe Asp Glu Ile Pro Thr 
1               5                   10                  15      


Val Val Gly Ile Phe Ser Ala Phe Gly Leu Val Phe Thr Val Ser Leu 
            20                  25                  30          


Phe Ala Trp Ile Cys Cys Gln Arg Lys Ser Ser Lys Ser Asn Lys Thr 
        35                  40                  45              


Pro Pro Tyr Lys Phe Val His Val Leu Lys Gly Val Asp Ile Tyr Pro 
    50                  55                  60                  


Glu Asn Leu Asn Ser Lys Lys Lys Phe Gly Ala Asp Asp Lys Asn Glu 
65                  70                  75                  80  


Val Lys Asn Lys Pro Ala Val Pro Lys Asn Ser Leu His Leu Asp Leu 
                85                  90                  95      


Glu Lys Arg Asp Leu Asn Gly Asn Phe Pro Lys Thr Asn Leu Lys Pro 
            100                 105                 110         


Gly Ser Pro Ser Asp Leu Glu Asn Ala Thr Pro Lys Leu Phe Leu Glu 
        115                 120                 125             


Gly Glu Lys Glu Ser Val Ser Pro Glu Ser Leu Lys Ser Ser Thr Ser 
    130                 135                 140                 


Leu Thr Ser Glu Glu Lys Gln Glu Lys Leu Gly Thr Leu Phe Phe Ser 
145                 150                 155                 160 


Leu Glu Tyr Asn Phe Glu Arg Lys Ala Phe Val Val Asn Ile Lys Glu 
                165                 170                 175     


Ala Arg Gly Leu Pro Ala Met Asp Glu Gln Ser Met Thr Ser Asp Pro 
            180                 185                 190         


Tyr Ile Lys Met Thr Ile Leu Pro Glu Lys Lys His Lys Val Lys Thr 
        195                 200                 205             


Arg Val Leu Arg Lys Thr Leu Asp Pro Ala Phe Asp Glu Thr Phe Thr 
    210                 215                 220                 


Phe Tyr Gly Ile Pro Tyr Thr Gln Ile Gln Glu Leu Ala Leu His Phe 
225                 230                 235                 240 


Thr Ile Leu Ser Phe Asp Arg Phe Ser Arg Asp Asp Ile Ile Gly Glu 
                245                 250                 255     


Val Leu Ile Pro Leu Ser Gly Ile Glu Leu Ser Glu Gly Lys Met Leu 
            260                 265                 270         


Met Asn Arg Glu Ile Ile Lys Arg Asn Val Arg Lys Ser Ser Gly Arg 
        275                 280                 285             


Gly Glu Leu Leu Ile Ser Leu Cys Tyr Gln Ser Thr Thr Asn Thr Leu 
    290                 295                 300                 


Thr Val Val Val Leu Lys Ala Arg His Leu Pro Lys Ser Asp Val Ser 
305                 310                 315                 320 


Gly Leu Ser Asp Pro Tyr Val Lys Val Asn Leu Tyr His Ala Lys Lys 
                325                 330                 335     


Arg Ile Ser Lys Lys Lys Thr His Val Lys Lys Cys Thr Pro Asn Ala 
            340                 345                 350         


Val Phe Asn Glu Leu Phe Val Phe Asp Ile Pro Cys Glu Gly Leu Glu 
        355                 360                 365             


Asp Ile Ser Val Glu Phe Leu Val Leu Asp Ser Glu Arg Gly Ser Arg 
    370                 375                 380                 


Asn Glu Val Ile Gly Gln Leu Val Leu Gly Ala Ala Ala Glu Gly Thr 
385                 390                 395                 400 


Gly Gly Glu His Trp Lys Glu Ile Cys Asp Tyr Pro Arg Arg Gln Ile 
                405                 410                 415     


Ala Lys Trp His Val Leu Cys Asp Gly 
            420                 425 


<210>  4723
<211>  825
<212>  PRT
<213>  Homo sapiens

<400>  4723

Met Phe Ser Gly Phe Asn Val Phe Arg Val Gly Ile Ser Phe Val Ile 
1               5                   10                  15      


Met Cys Ile Phe Tyr Met Pro Thr Val Asn Ser Leu Pro Glu Leu Ser 
            20                  25                  30          


Pro Gln Lys Tyr Phe Ser Thr Leu Gln Pro Gly Lys Ala Ser Leu Ala 
        35                  40                  45              


Tyr Phe Cys Gln Ala Asp Ser Pro Arg Thr Ser Val Phe Leu Glu Glu 
    50                  55                  60                  


Leu Asn Glu Ala Val Arg Pro Leu Gln Asp Tyr Gly Ile Ser Val Ala 
65                  70                  75                  80  


Lys Val Asn Cys Val Lys Glu Glu Ile Ser Arg Tyr Cys Gly Lys Glu 
                85                  90                  95      


Lys Asp Leu Met Lys Ala Tyr Leu Phe Lys Gly Asn Ile Leu Leu Arg 
            100                 105                 110         


Glu Phe Pro Thr Asp Thr Leu Phe Asp Val Asn Ala Ile Val Ala His 
        115                 120                 125             


Val Leu Phe Ala Leu Leu Phe Ser Glu Val Lys Tyr Ile Thr Asn Leu 
    130                 135                 140                 


Glu Asp Leu Gln Asn Ile Glu Asn Ala Leu Lys Gly Lys Ala Asn Ile 
145                 150                 155                 160 


Ile Phe Ser Tyr Val Arg Ala Ile Gly Ile Pro Glu His Arg Ala Val 
                165                 170                 175     


Met Glu Ala Ala Phe Val Tyr Gly Thr Thr Tyr Gln Phe Val Leu Thr 
            180                 185                 190         


Thr Glu Ile Ala Leu Leu Glu Ser Ile Gly Ser Glu Asp Val Glu Tyr 
        195                 200                 205             


Ala His Leu Tyr Phe Phe His Cys Lys Leu Val Leu Asp Leu Thr Gln 
    210                 215                 220                 


Gln Cys Arg Arg Thr Leu Met Glu Gln Pro Leu Thr Thr Leu Asn Ile 
225                 230                 235                 240 


His Leu Phe Ile Lys Thr Met Lys Ala Pro Leu Leu Thr Glu Val Ala 
                245                 250                 255     


Glu Asp Pro Gln Gln Val Ser Thr Val His Leu Gln Leu Gly Leu Pro 
            260                 265                 270         


Leu Val Phe Ile Val Ser Gln Gln Ala Thr Tyr Glu Ala Asp Arg Arg 
        275                 280                 285             


Thr Ala Glu Trp Val Ala Trp Arg Leu Leu Gly Lys Ala Gly Val Leu 
    290                 295                 300                 


Leu Leu Leu Arg Asp Ser Leu Glu Val Asn Ile Pro Gln Asp Ala Asn 
305                 310                 315                 320 


Val Val Phe Lys Arg Ala Glu Glu Gly Val Pro Val Glu Phe Leu Val 
                325                 330                 335     


Leu His Asp Val Asp Leu Ile Ile Ser His Val Glu Asn Asn Met His 
            340                 345                 350         


Ile Glu Glu Ile Gln Glu Asp Glu Asp Asn Asp Met Glu Gly Pro Asp 
        355                 360                 365             


Ile Asp Val Gln Asp Asp Glu Val Ala Glu Thr Val Phe Arg Asp Arg 
    370                 375                 380                 


Lys Arg Lys Leu Pro Leu Glu Leu Thr Val Glu Leu Thr Glu Glu Thr 
385                 390                 395                 400 


Phe Asn Ala Thr Val Met Ala Ser Asp Ser Ile Val Leu Phe Tyr Ala 
                405                 410                 415     


Gly Trp Gln Ala Val Ser Met Ala Phe Leu Gln Ser Tyr Ile Asp Val 
            420                 425                 430         


Ala Val Lys Leu Lys Gly Thr Ser Thr Met Leu Leu Thr Arg Ile Asn 
        435                 440                 445             


Cys Ala Asp Trp Ser Asp Val Cys Thr Lys Gln Asn Val Thr Glu Phe 
    450                 455                 460                 


Pro Ile Ile Lys Met Tyr Lys Lys Gly Glu Asn Pro Val Ser Tyr Ala 
465                 470                 475                 480 


Gly Met Leu Gly Thr Glu Asp Leu Leu Lys Phe Ile Gln Leu Asn Arg 
                485                 490                 495     


Ile Ser Tyr Pro Val Asn Ile Thr Ser Ile Gln Glu Ala Glu Glu Tyr 
            500                 505                 510         


Leu Ser Gly Glu Leu Tyr Lys Asp Leu Ile Leu Tyr Ser Ser Val Ser 
        515                 520                 525             


Val Leu Gly Leu Phe Ser Pro Thr Met Lys Thr Ala Lys Glu Asp Phe 
    530                 535                 540                 


Ser Glu Ala Gly Asn Tyr Leu Lys Gly Tyr Val Ile Thr Gly Ile Tyr 
545                 550                 555                 560 


Ser Glu Glu Asp Val Leu Leu Leu Ser Thr Lys Tyr Ala Ala Ser Leu 
                565                 570                 575     


Pro Ala Leu Leu Leu Ala Arg His Thr Glu Gly Lys Ile Glu Ser Ile 
            580                 585                 590         


Pro Leu Ala Ser Thr His Ala Gln Asp Ile Val Gln Ile Ile Thr Asp 
        595                 600                 605             


Ala Leu Leu Glu Met Phe Pro Glu Ile Thr Val Glu Asn Leu Pro Ser 
    610                 615                 620                 


Tyr Phe Arg Leu Gln Lys Pro Leu Leu Ile Leu Phe Ser Asp Gly Thr 
625                 630                 635                 640 


Val Asn Pro Gln Tyr Lys Lys Ala Ile Leu Thr Leu Val Lys Gln Lys 
                645                 650                 655     


Tyr Leu Asp Ser Phe Thr Pro Cys Trp Leu Asn Leu Lys Asn Thr Pro 
            660                 665                 670         


Val Gly Arg Gly Ile Leu Arg Ala Tyr Phe Asp Pro Leu Pro Pro Leu 
        675                 680                 685             


Pro Leu Leu Val Leu Val Asn Leu His Ser Gly Gly Gln Val Phe Ala 
    690                 695                 700                 


Phe Pro Ser Asp Gln Ala Ile Ile Glu Glu Asn Leu Val Leu Trp Leu 
705                 710                 715                 720 


Lys Lys Leu Glu Ala Gly Leu Glu Asn His Ile Thr Ile Leu Pro Ala 
                725                 730                 735     


Gln Glu Trp Lys Pro Pro Leu Pro Ala Tyr Asp Phe Leu Ser Met Ile 
            740                 745                 750         


Asp Ala Ala Thr Ser Gln Arg Gly Thr Arg Lys Val Pro Lys Cys Met 
        755                 760                 765             


Lys Glu Thr Asp Val Gln Glu Asn Asp Lys Glu Gln His Glu Asp Lys 
    770                 775                 780                 


Ser Ala Val Arg Lys Glu Pro Ile Glu Thr Leu Arg Ile Lys His Trp 
785                 790                 795                 800 


Asn Arg Ser Asn Trp Phe Lys Glu Ala Glu Lys Ser Phe Arg Arg Asp 
                805                 810                 815     


Lys Glu Leu Gly Cys Ser Lys Val Asn 
            820                 825 


<210>  4724
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  4724

Met Ser Ser Cys Arg Gly Gln Lys Val Ala Gly Gly Leu Arg Val Val 
1               5                   10                  15      


Ser Pro Phe Pro Leu Cys Gln Pro Ala Gly Glu Pro Ser Gln Gly Lys 
            20                  25                  30          


Met Arg Ser Ser Cys Val Leu Leu Thr Ala Leu Val Ala Leu Ala Ala 
        35                  40                  45              


Tyr Tyr Val Tyr Ile Pro Leu Pro Gly Ser Val Ser Asp Pro Trp Lys 
    50                  55                  60                  


Leu Met Leu Leu Asp Ala Thr Phe Arg Gly Ala Gln Gln Val Ser Asn 
65                  70                  75                  80  


Leu Ile His Tyr Leu Gly Leu Ser His His Leu Leu Ala Leu Asn Phe 
                85                  90                  95      


Ile Ile Val Ser Phe Gly Lys Lys Ser Ala Trp Ser Ser Ala Gln Val 
            100                 105                 110         


Lys Val Thr Asp Thr Asp Phe Asp Gly Val Glu Val Arg Val Phe Glu 
        115                 120                 125             


Gly Pro Pro Lys Pro Glu Glu Pro Leu Lys Arg Ser Val Val Tyr Ile 
    130                 135                 140                 


His Gly Gly Gly Trp Ala Leu Ala Ser Ala Lys Ile Arg Tyr Tyr Asp 
145                 150                 155                 160 


Glu Leu Cys Thr Ala Met Ala Glu Glu Leu Asn Ala Val Ile Val Ser 
                165                 170                 175     


Ile Glu Tyr Arg Leu Val Pro Lys Val Tyr Phe Pro Glu Gln Ile His 
            180                 185                 190         


Asp Val Val Arg Ala Thr Lys Tyr Phe Leu Lys Pro Glu Val Leu Gln 
        195                 200                 205             


Lys Tyr Met Val Asp Pro Gly Arg Ile Cys Ile Ser Gly Asp Ser Ala 
    210                 215                 220                 


Gly Gly Asn Leu Ala Ala Ala Leu Gly Gln Gln Phe Thr Gln Asp Ala 
225                 230                 235                 240 


Ser Leu Lys Asn Lys Leu Lys Leu Gln Ala Leu Ile Tyr Pro Val Leu 
                245                 250                 255     


Gln Ala Leu Asp Phe Asn Thr Pro Ser Tyr Gln Gln Asn Val Asn Thr 
            260                 265                 270         


Pro Ile Leu Pro Arg Tyr Val Met Val Lys Tyr Trp Val Asp Tyr Phe 
        275                 280                 285             


Lys Gly Asn Tyr Asp Phe Val Gln Ala Met Ile Val Asn Asn His Thr 
    290                 295                 300                 


Ser Leu Asp Val Glu Glu Ala Ala Ala Val Arg Ala Arg Leu Asn Trp 
305                 310                 315                 320 


Thr Ser Leu Leu Pro Ala Ser Phe Thr Lys Asn Tyr Lys Pro Val Val 
                325                 330                 335     


Gln Thr Thr Gly Asn Ala Arg Ile Val Gln Glu Leu Pro Gln Leu Leu 
            340                 345                 350         


Asp Ala Arg Ser Ala Pro Leu Ile Ala Asp Gln Ala Val Leu Gln Leu 
        355                 360                 365             


Leu Pro Lys Thr Tyr Ile Leu Thr Cys Glu His Asp Val Leu Arg Asp 
    370                 375                 380                 


Asp Gly Ile Met Tyr Ala Lys Arg Leu Glu Ser Ala Gly Val Glu Val 
385                 390                 395                 400 


Thr Leu Asp His Phe Glu Asp Gly Phe His Gly Cys Met Ile Phe Thr 
                405                 410                 415     


Ser Trp Pro Thr Asn Phe Ser Val Gly Ile Arg Thr Arg Asn Ser Tyr 
            420                 425                 430         


Ile Lys Trp Leu Asp Gln Asn Leu 
        435                 440 


<210>  4725
<211>  1030
<212>  PRT
<213>  Homo sapiens

<400>  4725

Met Arg Ser Glu Ala Leu Leu Leu Tyr Phe Thr Leu Leu His Phe Ala 
1               5                   10                  15      


Gly Ala Gly Phe Pro Glu Asp Ser Glu Pro Ile Ser Ile Ser His Gly 
            20                  25                  30          


Asn Tyr Thr Lys Gln Tyr Pro Val Phe Val Gly His Lys Pro Gly Arg 
        35                  40                  45              


Asn Thr Thr Gln Arg His Arg Leu Asp Ile Gln Met Ile Met Ile Met 
    50                  55                  60                  


Asn Gly Thr Leu Tyr Ile Ala Ala Arg Asp His Ile Tyr Thr Val Asp 
65                  70                  75                  80  


Ile Asp Thr Ser His Thr Glu Glu Ile Tyr Cys Ser Lys Lys Leu Thr 
                85                  90                  95      


Trp Lys Ser Arg Gln Ala Asp Val Asp Thr Cys Arg Met Lys Gly Lys 
            100                 105                 110         


His Lys Asp Glu Cys His Asn Phe Ile Lys Val Leu Leu Lys Lys Asn 
        115                 120                 125             


Asp Asp Ala Leu Phe Val Cys Gly Thr Asn Ala Phe Asn Pro Ser Cys 
    130                 135                 140                 


Arg Asn Tyr Lys Met Asp Thr Leu Glu Pro Phe Gly Asp Glu Phe Ser 
145                 150                 155                 160 


Gly Met Ala Arg Cys Pro Tyr Asp Ala Lys His Ala Asn Val Ala Leu 
                165                 170                 175     


Phe Ala Asp Gly Lys Leu Tyr Ser Ala Thr Val Thr Asp Phe Leu Ala 
            180                 185                 190         


Ile Asp Ala Val Ile Tyr Arg Ser Leu Gly Glu Ser Pro Thr Leu Arg 
        195                 200                 205             


Thr Val Lys His Asp Ser Lys Trp Leu Lys Glu Pro Tyr Phe Val Gln 
    210                 215                 220                 


Ala Val Asp Tyr Gly Asp Tyr Ile Tyr Phe Phe Phe Arg Glu Ile Ala 
225                 230                 235                 240 


Val Glu Tyr Asn Thr Met Gly Lys Val Val Phe Pro Arg Val Ala Gln 
                245                 250                 255     


Val Cys Lys Asn Asp Met Gly Gly Ser Gln Arg Val Leu Glu Lys Gln 
            260                 265                 270         


Trp Thr Ser Phe Leu Lys Ala Arg Leu Asn Cys Ser Val Pro Gly Asp 
        275                 280                 285             


Ser His Phe Tyr Phe Asn Ile Leu Gln Ala Val Thr Asp Val Ile Arg 
    290                 295                 300                 


Ile Asn Gly Arg Asp Val Val Leu Ala Thr Phe Ser Thr Pro Tyr Asn 
305                 310                 315                 320 


Ser Ile Pro Gly Ser Ala Val Cys Ala Tyr Asp Met Leu Asp Ile Ala 
                325                 330                 335     


Ser Val Phe Thr Gly Arg Phe Lys Glu Gln Lys Ser Pro Asp Ser Thr 
            340                 345                 350         


Trp Thr Pro Val Pro Asp Glu Arg Val Pro Lys Pro Arg Pro Gly Cys 
        355                 360                 365             


Cys Ala Gly Ser Ser Ser Leu Glu Arg Tyr Ala Thr Ser Asn Glu Phe 
    370                 375                 380                 


Pro Asp Asp Thr Leu Asn Phe Ile Lys Thr His Pro Leu Met Asp Glu 
385                 390                 395                 400 


Ala Val Pro Ser Ile Phe Asn Arg Pro Trp Phe Leu Arg Thr Met Val 
                405                 410                 415     


Arg Tyr Arg Leu Thr Lys Ile Ala Val Asp Thr Ala Ala Gly Pro Tyr 
            420                 425                 430         


Gln Asn His Thr Val Val Phe Leu Gly Ser Glu Lys Gly Ile Ile Leu 
        435                 440                 445             


Lys Phe Leu Ala Arg Ile Gly Asn Ser Gly Phe Leu Asn Asp Ser Leu 
    450                 455                 460                 


Phe Leu Glu Glu Met Ser Val Tyr Asn Ser Glu Lys Cys Ser Tyr Asp 
465                 470                 475                 480 


Gly Val Glu Asp Lys Arg Ile Met Gly Met Gln Leu Asp Arg Ala Ser 
                485                 490                 495     


Ser Ser Leu Tyr Val Ala Phe Ser Thr Cys Val Ile Lys Val Pro Leu 
            500                 505                 510         


Gly Arg Cys Glu Arg His Gly Lys Cys Lys Lys Thr Cys Ile Ala Ser 
        515                 520                 525             


Arg Asp Pro Tyr Cys Gly Trp Ile Lys Glu Gly Gly Ala Cys Ser His 
    530                 535                 540                 


Leu Ser Pro Asn Ser Arg Leu Thr Phe Glu Gln Asp Ile Glu Arg Gly 
545                 550                 555                 560 


Asn Thr Asp Gly Leu Gly Asp Cys His Asn Ser Phe Val Ala Leu Asn 
                565                 570                 575     


Gly His Ser Ser Ser Leu Leu Pro Ser Thr Thr Thr Ser Asp Ser Thr 
            580                 585                 590         


Ala Gln Glu Gly Tyr Glu Ser Arg Gly Gly Met Leu Asp Trp Lys His 
        595                 600                 605             


Leu Leu Asp Ser Pro Asp Ser Thr Asp Pro Leu Gly Ala Val Ser Ser 
    610                 615                 620                 


His Asn His Gln Asp Lys Lys Gly Val Ile Arg Glu Ser Tyr Leu Lys 
625                 630                 635                 640 


Gly His Asp Gln Leu Val Pro Val Thr Leu Leu Ala Ile Ala Val Ile 
                645                 650                 655     


Leu Ala Phe Val Met Gly Ala Val Phe Ser Gly Ile Thr Val Tyr Cys 
            660                 665                 670         


Val Cys Asp His Arg Arg Lys Asp Val Ala Val Val Gln Arg Lys Glu 
        675                 680                 685             


Lys Glu Leu Thr His Ser Arg Arg Gly Ser Met Ser Ser Val Thr Lys 
    690                 695                 700                 


Leu Ser Gly Leu Phe Gly Asp Thr Gln Ser Lys Asp Pro Lys Pro Glu 
705                 710                 715                 720 


Ala Ile Leu Thr Pro Leu Met His Asn Gly Lys Leu Ala Thr Pro Gly 
                725                 730                 735     


Asn Thr Ala Lys Met Leu Ile Lys Ala Asp Gln His His Leu Asp Leu 
            740                 745                 750         


Thr Ala Leu Pro Thr Pro Glu Ser Thr Pro Thr Leu Gln Gln Lys Arg 
        755                 760                 765             


Lys Pro Ser Arg Gly Ser Arg Glu Trp Glu Arg Asn Gln Asn Leu Ile 
    770                 775                 780                 


Asn Ala Cys Thr Lys Asp Met Pro Pro Met Gly Ser Pro Val Ile Pro 
785                 790                 795                 800 


Thr Asp Leu Pro Leu Arg Ala Ser Pro Ser His Ile Pro Ser Val Val 
                805                 810                 815     


Val Leu Pro Ile Thr Gln Gln Gly Tyr Gln His Glu Tyr Val Asp Gln 
            820                 825                 830         


Pro Lys Met Ser Glu Val Ala Gln Met Ala Leu Glu Asp Gln Ala Ala 
        835                 840                 845             


Thr Leu Glu Tyr Lys Thr Ile Lys Glu His Leu Ser Ser Lys Ser Pro 
    850                 855                 860                 


Asn His Gly Val Asn Leu Val Glu Asn Leu Asp Ser Leu Pro Pro Lys 
865                 870                 875                 880 


Val Pro Gln Arg Glu Ala Ser Leu Gly Pro Pro Gly Ala Ser Leu Ser 
                885                 890                 895     


Gln Thr Gly Leu Ser Lys Arg Leu Glu Met His His Ser Ser Ser Tyr 
            900                 905                 910         


Gly Val Asp Tyr Lys Arg Ser Tyr Pro Thr Asn Ser Leu Thr Arg Ser 
        915                 920                 925             


His Gln Ala Thr Thr Leu Lys Arg Asn Asn Thr Asn Ser Ser Asn Ser 
    930                 935                 940                 


Ser His Leu Ser Arg Asn Gln Ser Phe Gly Arg Gly Asp Asn Pro Pro 
945                 950                 955                 960 


Pro Ala Pro Gln Arg Val Asp Ser Ile Gln Val His Ser Ser Gln Pro 
                965                 970                 975     


Ser Gly Gln Ala Val Thr Val Ser Arg Gln Pro Ser Leu Asn Ala Tyr 
            980                 985                 990         


Asn Ser Leu Thr Arg Ser Gly Leu  Lys Arg Thr Pro Ser  Leu Lys Pro 
        995                 1000                 1005             


Asp Val  Pro Pro Lys Pro Ser  Phe Ala Pro Leu Ser  Thr Ser Met 
    1010                 1015                 1020             


Lys Pro  Asn Asp Ala Cys Thr  
    1025                 1030 


<210>  4726
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  4726

Met Leu Met Pro Leu Cys Gly Leu Leu Trp Trp Trp Trp Cys Cys Cys 
1               5                   10                  15      


Ser Gly Trp Tyr Cys Tyr Gly Leu Cys Ala Pro Ala Pro Gln Met Leu 
            20                  25                  30          


Arg His Gln Gly Leu Leu Lys Cys Arg Cys Arg Met Leu Phe Asn Asp 
        35                  40                  45              


Leu Lys Val Phe Leu Leu Arg Arg Pro Pro Gln Ala Pro Leu Pro Met 
    50                  55                  60                  


His Gly Asp Pro Gln Pro Pro Gly Leu Ala Ala Asn Asn Thr Leu Pro 
65                  70                  75                  80  


Ala Leu Gly Ala Gly Gly Trp Ala Gly Trp Arg Gly Pro Arg Glu Val 
                85                  90                  95      


Val Gly Arg Glu Pro Pro Pro Val Pro Pro Pro Pro Pro Leu Pro Pro 
            100                 105                 110         


Ser Ser Val Glu Asp Asp Trp Gly Gly Pro Ala Thr Glu Pro Pro Ala 
        115                 120                 125             


Ser Leu Leu Ser Ser Ala Ser Ser Asp Asp Phe Cys Lys Glu Lys Thr 
    130                 135                 140                 


Glu Asp Arg Tyr Ser Leu Gly Ser Ser Leu Asp Ser Gly Met Arg Thr 
145                 150                 155                 160 


Pro Leu Cys Arg Ile Cys Phe Gln Gly Pro Glu Gln Gly Glu Leu Leu 
                165                 170                 175     


Ser Pro Cys Arg Cys Asp Gly Ser Val Lys Cys Thr His Gln Pro Cys 
            180                 185                 190         


Leu Ile Lys Trp Ile Ser Glu Arg Gly Cys Trp Ser Cys Glu Leu Cys 
        195                 200                 205             


Tyr Tyr Lys Tyr His Val Ile Ala Ile Ser Thr Lys Asn Pro Leu Gln 
    210                 215                 220                 


Trp Gln Ala Ile Ser Leu Thr Val Ile Glu Lys Val Gln Val Ala Ala 
225                 230                 235                 240 


Ala Ile Leu Gly Ser Leu Phe Leu Ile Ala Ser Ile Ser Trp Leu Ile 
                245                 250                 255     


Trp Ser Thr Phe Ser Pro Ser Ala Arg Trp Gln Arg Gln Asp Leu Leu 
            260                 265                 270         


Phe Gln Ile Cys Tyr Gly Met Tyr Gly Phe Met Asp Val Val Cys Ile 
        275                 280                 285             


Gly Leu Ile Ile His Glu Gly Pro Ser Val Tyr Arg Ile Phe Lys Arg 
    290                 295                 300                 


Trp Gln Ala Val Asn Gln Gln Trp Lys Val Leu Asn Tyr Asp Lys Thr 
305                 310                 315                 320 


Lys Asp Leu Glu Asp Gln Lys Ala Gly Gly Arg Thr Asn Pro Arg Thr 
                325                 330                 335     


Ser Ser Ser Thr Gln Ala Asn Ile Pro Ser Ser Glu Glu Glu Thr Ala 
            340                 345                 350         


Gly Thr Pro Ala Pro Glu Gln Gly Pro Ala Gln Ala Ala Gly His Pro 
        355                 360                 365             


Ser Gly Pro Leu Ser His His His Cys Ala Tyr Thr Ile Leu His Ile 
    370                 375                 380                 


Leu Ser His Leu Arg Pro His Glu Gln Arg Ser Pro Pro Gly Ser Ser 
385                 390                 395                 400 


Arg Glu Leu Val Met Arg Val Thr Thr Val 
                405                 410 


<210>  4727
<211>  896
<212>  PRT
<213>  Homo sapiens

<400>  4727

Met Ile Val Leu Leu Leu Phe Ala Leu Leu Trp Met Val Glu Gly Val 
1               5                   10                  15      


Phe Ser Gln Leu His Tyr Thr Val Gln Glu Glu Gln Glu His Gly Thr 
            20                  25                  30          


Phe Val Gly Asn Ile Ala Glu Asp Leu Gly Leu Asp Ile Thr Lys Leu 
        35                  40                  45              


Ser Ala Arg Gly Phe Gln Thr Val Pro Asn Ser Arg Thr Pro Tyr Leu 
    50                  55                  60                  


Asp Leu Asn Leu Glu Thr Gly Val Leu Tyr Val Asn Glu Lys Ile Asp 
65                  70                  75                  80  


Arg Glu Gln Ile Cys Lys Gln Ser Pro Ser Cys Val Leu His Leu Glu 
                85                  90                  95      


Val Phe Leu Glu Asn Pro Leu Glu Leu Phe Gln Val Glu Ile Glu Val 
            100                 105                 110         


Leu Asp Ile Asn Asp Asn Pro Pro Ser Phe Pro Glu Pro Asp Leu Thr 
        115                 120                 125             


Val Glu Ile Ser Glu Ser Ala Thr Pro Gly Thr Arg Phe Pro Leu Glu 
    130                 135                 140                 


Ser Ala Phe Asp Pro Asp Val Gly Thr Asn Ser Leu Arg Asp Tyr Glu 
145                 150                 155                 160 


Ile Thr Pro Asn Ser Tyr Phe Ser Leu Asp Val Gln Thr Gln Gly Asp 
                165                 170                 175     


Gly Asn Arg Phe Ala Glu Leu Val Leu Glu Lys Pro Leu Asp Arg Glu 
            180                 185                 190         


Gln Gln Ala Val His Arg Tyr Val Leu Thr Ala Val Asp Gly Gly Gly 
        195                 200                 205             


Gly Gly Gly Val Gly Glu Gly Gly Gly Gly Gly Gly Gly Ala Gly Leu 
    210                 215                 220                 


Pro Pro Gln Gln Gln Arg Thr Gly Thr Ala Leu Leu Thr Ile Arg Val 
225                 230                 235                 240 


Leu Asp Ser Asn Asp Asn Val Pro Ala Phe Asp Gln Pro Val Tyr Thr 
                245                 250                 255     


Val Ser Leu Pro Glu Asn Ser Pro Pro Gly Thr Leu Val Ile Gln Leu 
            260                 265                 270         


Asn Ala Thr Asp Pro Asp Glu Gly Gln Asn Gly Glu Val Val Tyr Ser 
        275                 280                 285             


Phe Ser Ser His Ile Ser Pro Arg Ala Arg Glu Leu Phe Gly Leu Ser 
    290                 295                 300                 


Pro Arg Thr Gly Arg Leu Glu Val Ser Gly Glu Leu Asp Tyr Glu Glu 
305                 310                 315                 320 


Ser Pro Val Tyr Gln Val Tyr Val Gln Ala Lys Asp Leu Gly Pro Asn 
                325                 330                 335     


Ala Val Pro Ala His Cys Lys Val Leu Val Arg Val Leu Asp Ala Asn 
            340                 345                 350         


Asp Asn Ala Pro Glu Ile Ser Phe Ser Thr Val Lys Glu Ala Val Ser 
        355                 360                 365             


Glu Gly Ala Ala Pro Gly Thr Val Val Ala Leu Phe Ser Val Thr Asp 
    370                 375                 380                 


Arg Asp Ser Glu Glu Asn Gly Gln Val Gln Cys Glu Leu Leu Gly Asp 
385                 390                 395                 400 


Val Pro Phe Arg Leu Lys Ser Ser Phe Lys Asn Tyr Tyr Thr Ile Val 
                405                 410                 415     


Thr Glu Ala Pro Leu Asp Arg Glu Ala Gly Asp Ser Tyr Thr Leu Thr 
            420                 425                 430         


Val Val Ala Arg Asp Arg Gly Glu Pro Ala Leu Ser Thr Ser Lys Ser 
        435                 440                 445             


Ile Gln Val Gln Val Ser Asp Val Asn Asp Asn Ala Pro Arg Phe Ser 
    450                 455                 460                 


Gln Pro Val Tyr Asp Val Tyr Val Thr Glu Asn Asn Val Pro Gly Ala 
465                 470                 475                 480 


Tyr Ile Tyr Ala Val Ser Ala Thr Asp Arg Asp Glu Gly Ala Asn Ala 
                485                 490                 495     


Gln Leu Ala Tyr Ser Ile Leu Glu Cys Gln Ile Gln Gly Met Ser Val 
            500                 505                 510         


Phe Thr Tyr Val Ser Ile Asn Ser Glu Asn Gly Tyr Leu Tyr Ala Leu 
        515                 520                 525             


Arg Ser Phe Asp Tyr Glu Gln Leu Lys Asp Phe Ser Phe Gln Val Glu 
    530                 535                 540                 


Ala Arg Asp Ala Gly Ser Pro Gln Ala Leu Ala Gly Asn Ala Thr Val 
545                 550                 555                 560 


Asn Ile Leu Ile Val Asp Gln Asn Asp Asn Ala Pro Ala Ile Val Ala 
                565                 570                 575     


Pro Leu Pro Gly Arg Asn Gly Thr Pro Ala Arg Glu Val Leu Pro Arg 
            580                 585                 590         


Ser Ala Glu Pro Gly Tyr Leu Leu Thr Arg Val Ala Ala Val Asp Ala 
        595                 600                 605             


Asp Asp Gly Glu Asn Ala Arg Leu Thr Tyr Ser Ile Val Arg Gly Asn 
    610                 615                 620                 


Glu Met Asn Leu Phe Arg Met Asp Trp Arg Thr Gly Glu Leu Arg Thr 
625                 630                 635                 640 


Ala Arg Arg Val Pro Ala Lys Arg Asp Pro Gln Arg Pro Tyr Glu Leu 
                645                 650                 655     


Val Ile Glu Val Arg Asp His Gly Gln Pro Pro Leu Ser Ser Thr Ala 
            660                 665                 670         


Thr Leu Val Val Gln Leu Val Asp Gly Ala Val Glu Pro Gln Gly Gly 
        675                 680                 685             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Glu His Gln Arg Pro Ser Arg 
    690                 695                 700                 


Ser Gly Gly Gly Glu Thr Ser Leu Asp Leu Thr Leu Ile Leu Ile Ile 
705                 710                 715                 720 


Ala Leu Gly Ser Val Ser Phe Ile Phe Leu Leu Ala Met Ile Val Leu 
                725                 730                 735     


Ala Val Arg Cys Gln Lys Glu Lys Lys Leu Asn Ile Tyr Thr Cys Leu 
            740                 745                 750         


Ala Ser Asp Cys Cys Leu Cys Cys Cys Cys Cys Gly Gly Gly Gly Ser 
        755                 760                 765             


Thr Cys Cys Gly Arg Gln Ala Arg Ala Arg Lys Lys Lys Leu Ser Lys 
    770                 775                 780                 


Ser Asp Ile Met Leu Val Gln Ser Ser Asn Val Pro Ser Asn Pro Ala 
785                 790                 795                 800 


Gln Val Pro Ile Glu Glu Ser Gly Gly Phe Gly Ser His His His Asn 
                805                 810                 815     


Gln Asn Tyr Cys Tyr Gln Val Cys Leu Thr Pro Glu Ser Ala Lys Thr 
            820                 825                 830         


Asp Leu Met Phe Leu Lys Pro Cys Ser Pro Ser Arg Ser Thr Asp Thr 
        835                 840                 845             


Glu His Asn Pro Cys Gly Ala Ile Val Thr Gly Tyr Thr Asp Gln Gln 
    850                 855                 860                 


Pro Asp Ile Ile Ser Asn Gly Ser Ile Leu Ser Asn Glu Val Arg Leu 
865                 870                 875                 880 


Lys Arg Lys Asp His His Leu Ser Ser Pro Pro Ser Glu Ser Leu Leu 
                885                 890                 895     


<210>  4728
<211>  612
<212>  PRT
<213>  Homo sapiens

<400>  4728

Met Gly Ala Ala Pro Ser Pro Thr Gln Ala Ser Ser Arg Gly Gly Gly 
1               5                   10                  15      


Pro Gly Pro Pro Ala Pro Thr Arg Ala Val Ser Ser Ser Ser Arg Ala 
            20                  25                  30          


Arg Gly Gly Ala Leu Ser Ala Leu Gly Pro Ser Pro Ala Arg Pro Leu 
        35                  40                  45              


Thr Thr Ser Pro Ala Pro Ala Pro Pro Pro Arg Ser Arg Pro Ala Arg 
    50                  55                  60                  


Gln Gln Pro Asp Pro Gln Cys Trp Glu Lys Arg Gly Gly Ala Gly Gly 
65                  70                  75                  80  


Asp Thr Lys Gly Gly Ala Ala Gly Pro Gly Pro Gly Arg Leu Arg Gly 
                85                  90                  95      


Met Asp Ala Glu Tyr Pro Ala Phe Glu Pro Pro Leu Cys Ser Glu Leu 
            100                 105                 110         


Lys His Leu Cys Arg Arg Leu Arg Glu Ala Tyr Arg Glu Leu Lys Glu 
        115                 120                 125             


Asp Leu Thr Pro Phe Lys Asp Asp Arg Tyr Tyr Arg Leu Ala Pro Met 
    130                 135                 140                 


Arg Leu Tyr Thr Leu Ser Lys Arg His Phe Val Leu Val Phe Val Val 
145                 150                 155                 160 


Phe Phe Ile Cys Phe Gly Leu Thr Ile Phe Val Gly Ile Arg Gly Pro 
                165                 170                 175     


Lys Val Ile Gln Thr Ser Ala Ala Asn Phe Ser Leu Asn Asn Ser Lys 
            180                 185                 190         


Lys Leu Lys Pro Ile Gln Ile Leu Ser Asn Pro Leu Ser Thr Tyr Asn 
        195                 200                 205             


Gln Gln Leu Trp Leu Thr Cys Val Val Glu Leu Asp Gln Ser Lys Glu 
    210                 215                 220                 


Thr Ser Ile Lys Thr Ser Phe Pro Met Thr Val Lys Val Asp Gly Val 
225                 230                 235                 240 


Ala Gln Asp Gly Thr Thr Met Tyr Ile His Asn Lys Val His Asn Arg 
                245                 250                 255     


Thr Arg Thr Leu Thr Cys Ala Gly Lys Cys Ala Glu Ile Ile Val Ala 
            260                 265                 270         


His Leu Gly Tyr Leu Asn Tyr Thr Gln Tyr Thr Val Ile Val Gly Phe 
        275                 280                 285             


Glu His Leu Lys Leu Pro Ile Lys Gly Met Asn Phe Thr Trp Lys Thr 
    290                 295                 300                 


Tyr Asn Pro Ala Phe Ser Arg Leu Glu Ile Trp Phe Arg Phe Phe Phe 
305                 310                 315                 320 


Val Val Leu Thr Phe Ile Val Thr Cys Leu Phe Ala His Ser Leu Arg 
                325                 330                 335     


Lys Phe Ser Met Arg Asp Trp Gly Ile Glu Gln Lys Trp Met Ser Val 
            340                 345                 350         


Leu Leu Pro Leu Leu Leu Leu Tyr Asn Asp Pro Phe Phe Pro Leu Ser 
        355                 360                 365             


Phe Leu Val Asn Ser Trp Leu Pro Gly Met Leu Asp Asp Leu Phe Gln 
    370                 375                 380                 


Ser Met Phe Leu Cys Ala Leu Leu Leu Phe Trp Leu Cys Val Tyr His 
385                 390                 395                 400 


Gly Ile Arg Val Gln Gly Glu Arg Lys Cys Leu Thr Phe Tyr Leu Pro 
                405                 410                 415     


Lys Phe Phe Ile Val Gly Leu Leu Trp Leu Ala Ser Val Thr Leu Gly 
            420                 425                 430         


Ile Trp Gln Thr Val Asn Glu Leu His Asp Pro Met Tyr Gln Tyr Arg 
        435                 440                 445             


Val Asp Thr Gly Asn Phe Gln Gly Met Lys Val Phe Phe Met Val Val 
    450                 455                 460                 


Ala Ala Val Tyr Ile Leu Tyr Leu Leu Phe Leu Ile Val Arg Ala Cys 
465                 470                 475                 480 


Ser Glu Leu Arg His Met Pro Tyr Val Asp Leu Arg Leu Lys Phe Leu 
                485                 490                 495     


Thr Ala Leu Thr Phe Val Val Leu Val Ile Ser Ile Ala Ile Leu Tyr 
            500                 505                 510         


Leu Arg Phe Gly Ala Gln Val Leu Gln Asp Asn Phe Val Ala Glu Leu 
        515                 520                 525             


Ser Thr His Tyr Gln Asn Ser Ala Glu Phe Leu Ser Phe Tyr Gly Leu 
    530                 535                 540                 


Leu Asn Phe Tyr Leu Tyr Thr Leu Ala Phe Val Tyr Ser Pro Ser Lys 
545                 550                 555                 560 


Asn Ala Leu Tyr Glu Ser Gln Leu Lys Asp Asn Pro Ala Phe Ser Met 
                565                 570                 575     


Leu Asn Asp Ser Asp Asp Asp Val Ile Tyr Gly Ser Asp Tyr Glu Glu 
            580                 585                 590         


Met Pro Leu Gln Asn Gly Gln Ala Ile Arg Ala Lys Tyr Lys Glu Glu 
        595                 600                 605             


Ser Asp Ser Asp 
    610         


<210>  4729
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  4729

Met Val Leu Ser Val Pro Val Ile Ala Leu Gly Ala Thr Leu Gly Thr 
1               5                   10                  15      


Ala Thr Ser Ile Leu Ala Leu Cys Gly Val Thr Cys Leu Cys Arg His 
            20                  25                  30          


Met His Pro Lys Lys Gly Leu Leu Pro Arg Asp Gln Asp Pro Asp Leu 
        35                  40                  45              


Glu Lys Ala Lys Pro Ser Leu Leu Gly Ser Ala Gln Gln Phe Asn Val 
    50                  55                  60                  


Lys Lys Ser Thr Glu Pro Val Gln Pro Arg Ala Leu Leu Lys Phe Pro 
65                  70                  75                  80  


Asp Ile Tyr Gly Pro Arg Pro Ala Val Thr Ala Pro Glu Val Ile Asn 
                85                  90                  95      


Tyr Ala Asp Tyr Ser Leu Arg Ser Thr Glu Glu Pro Thr Ala Pro Ala 
            100                 105                 110         


Ser Pro Gln Pro Pro Asn Asp Ser Arg Leu Lys Arg Gln Val Thr Glu 
        115                 120                 125             


Glu Leu Phe Ile Leu Pro Gln Asn Gly Val Val Glu Asp Val Cys Val 
    130                 135                 140                 


Met Glu Thr Trp Asn Pro Glu Lys Ala Ala Ser Trp Asn Gln Ala Pro 
145                 150                 155                 160 


Lys Leu His Tyr Cys Leu Asp Tyr Asp Cys Gln Lys Ala Glu Leu Phe 
                165                 170                 175     


Val Thr Arg Leu Glu Ala Val Thr Ser Asn His Asp Gly Gly Cys Asp 
            180                 185                 190         


Cys Tyr Val Gln Gly Ser Val Ala Asn Arg Thr Gly Ser Val Glu Ala 
        195                 200                 205             


Gln Thr Ala Leu Lys Lys Arg Gln Leu His Thr Thr Trp Glu Glu Gly 
    210                 215                 220                 


Leu Val Leu Pro Leu Ala Glu Glu Glu Leu Pro Thr Ala Thr Leu Thr 
225                 230                 235                 240 


Leu Thr Leu Arg Thr Cys Asp Arg Phe Ser Arg His Ser Val Ala Gly 
                245                 250                 255     


Glu Leu Arg Leu Gly Leu Asp Gly Thr Ser Val Pro Leu Gly Ala Ala 
            260                 265                 270         


Gln Trp Gly Glu Leu Lys Thr Ser Ala Lys Glu Pro Ser Ala Gly Ala 
        275                 280                 285             


Gly Glu Val Leu Leu Ser Ile Ser Tyr Leu Pro Ala Ala Asn Arg Leu 
    290                 295                 300                 


Leu Val Val Leu Ile Lys Ala Lys Asn Leu His Ser Asn Gln Ser Lys 
305                 310                 315                 320 


Glu Leu Leu Gly Lys Asp Val Ser Val Lys Val Thr Leu Lys His Gln 
                325                 330                 335     


Ala Arg Lys Leu Lys Lys Lys Gln Thr Lys Arg Ala Lys His Lys Ile 
            340                 345                 350         


Asn Pro Val Trp Asn Glu Met Ile Met Phe Glu Leu Pro Asp Asp Leu 
        355                 360                 365             


Leu Gln Ala Ser Ser Val Glu Leu Glu Val Leu Gly Gln Asp Asp Ser 
    370                 375                 380                 


Gly Gln Ser Cys Ala Leu Gly His Cys Ser Leu Gly Leu His Thr Ser 
385                 390                 395                 400 


Gly Ser Glu Arg Ser His Trp Glu Glu Met Leu Lys Asn Pro Arg Arg 
                405                 410                 415     


Gln Ile Ala Met Trp His Gln Leu His Leu 
            420                 425     


<210>  4730
<211>  889
<212>  PRT
<213>  Homo sapiens

<400>  4730

Met Glu Gly Gly Leu Ala Asp Gly Glu Pro Asp Arg Thr Ser Leu Leu 
1               5                   10                  15      


Gly Asp Ser Lys Asp Val Leu Gly Pro Ser Thr Val Val Ala Asn Ser 
            20                  25                  30          


Asp Glu Ser Gln Leu Leu Thr Pro Gly Lys Met Ser Gln Arg Gln Gly 
        35                  40                  45              


Lys Glu Ala Tyr Pro Thr Pro Thr Lys Asp Leu His Gln Pro Ser Leu 
    50                  55                  60                  


Ser Pro Ala Ser Pro His Ser Gln Gly Phe Glu Arg Gly Lys Glu Asp 
65                  70                  75                  80  


Ile Ser Gln Asn Lys Asp Glu Ser Ser Leu Ser Met Ser Lys Ser Lys 
                85                  90                  95      


Ser Glu Ser Lys Leu Tyr Asn Gly Ser Glu Lys Asp Ser Ser Thr Ser 
            100                 105                 110         


Ser Lys Leu Thr Lys Lys Glu Ser Leu Lys Val Gln Lys Lys Asn Tyr 
        115                 120                 125             


Arg Glu Glu Lys Lys Arg Ala Thr Lys Glu Leu Leu Ser Thr Ile Thr 
    130                 135                 140                 


Asp Pro Ser Val Ile Val Met Ala Asp Trp Leu Lys Ile Arg Gly Thr 
145                 150                 155                 160 


Leu Lys Ser Trp Thr Lys Leu Trp Cys Val Leu Lys Pro Gly Val Leu 
                165                 170                 175     


Leu Ile Tyr Lys Thr Gln Lys Asn Gly Gln Trp Val Gly Thr Val Leu 
            180                 185                 190         


Leu Asn Ala Cys Glu Ile Ile Glu Arg Pro Ser Lys Lys Asp Gly Phe 
        195                 200                 205             


Cys Phe Lys Leu Phe His Pro Leu Glu Gln Ser Ile Trp Ala Val Lys 
    210                 215                 220                 


Gly Pro Lys Gly Glu Ala Val Gly Ser Ile Thr Gln Pro Leu Pro Ser 
225                 230                 235                 240 


Ser Tyr Leu Ile Ile Arg Ala Thr Ser Glu Ser Asp Gly Arg Cys Trp 
                245                 250                 255     


Met Asp Ala Leu Glu Leu Ala Leu Lys Cys Ser Ser Leu Leu Lys Arg 
            260                 265                 270         


Thr Met Ile Arg Glu Gly Lys Glu His Asp Leu Ser Val Ser Ser Asp 
        275                 280                 285             


Ser Thr His Val Thr Phe Tyr Gly Leu Leu Arg Ala Asn Asn Leu His 
    290                 295                 300                 


Ser Gly Asp Asn Phe Gln Leu Asn Asp Ser Glu Ile Glu Arg Gln His 
305                 310                 315                 320 


Phe Lys Asp Gln Asp Met Tyr Ser Asp Lys Ser Asp Lys Glu Asn Asp 
                325                 330                 335     


Gln Glu His Asp Glu Ser Asp Asn Glu Val Met Gly Lys Ser Glu Glu 
            340                 345                 350         


Ser Asp Thr Asp Thr Ser Glu Arg Gln Asp Asp Ser Tyr Ile Glu Pro 
        355                 360                 365             


Glu Pro Val Glu Pro Leu Lys Glu Thr Thr Tyr Thr Glu Gln Ser His 
    370                 375                 380                 


Glu Glu Leu Gly Glu Ala Gly Glu Ala Ser Gln Thr Glu Thr Val Ser 
385                 390                 395                 400 


Glu Glu Asn Lys Ser Leu Ile Trp Thr Leu Leu Lys Gln Val Arg Pro 
                405                 410                 415     


Gly Met Asp Leu Ser Lys Val Val Leu Pro Thr Phe Ile Leu Glu Pro 
            420                 425                 430         


Arg Ser Phe Leu Asp Lys Leu Ser Asp Tyr Tyr Tyr His Ala Asp Phe 
        435                 440                 445             


Leu Ser Glu Ala Ala Leu Glu Glu Asn Pro Tyr Phe Arg Leu Lys Lys 
    450                 455                 460                 


Val Val Lys Trp Tyr Leu Ser Gly Phe Tyr Lys Lys Pro Lys Gly Leu 
465                 470                 475                 480 


Lys Lys Pro Tyr Asn Pro Ile Leu Gly Glu Thr Phe Arg Cys Leu Trp 
                485                 490                 495     


Ile His Pro Arg Thr Asn Ser Lys Thr Phe Tyr Ile Ala Glu Gln Val 
            500                 505                 510         


Ser His His Pro Pro Ile Ser Ala Phe Tyr Val Ser Asn Arg Lys Asp 
        515                 520                 525             


Gly Phe Cys Leu Ser Gly Ser Ile Leu Ala Lys Ser Lys Phe Tyr Gly 
    530                 535                 540                 


Asn Ser Leu Ser Ala Ile Leu Glu Gly Glu Ala Arg Leu Thr Phe Leu 
545                 550                 555                 560 


Asn Arg Gly Glu Asp Tyr Val Met Thr Met Pro Tyr Ala His Cys Lys 
                565                 570                 575     


Gly Ile Leu Tyr Gly Thr Met Thr Leu Glu Leu Gly Gly Thr Val Asn 
            580                 585                 590         


Ile Thr Cys Gln Lys Thr Gly Tyr Ser Ala Ile Leu Glu Phe Lys Leu 
        595                 600                 605             


Lys Pro Phe Leu Gly Ser Ser Asp Cys Val Asn Gln Ile Ser Gly Lys 
    610                 615                 620                 


Leu Lys Leu Gly Lys Glu Val Leu Ala Thr Leu Glu Gly His Trp Asp 
625                 630                 635                 640 


Ser Glu Val Phe Ile Thr Asp Lys Lys Thr Asp Asn Ser Glu Val Phe 
                645                 650                 655     


Trp Asn Pro Thr Pro Asp Ile Lys Gln Trp Arg Leu Ile Arg His Thr 
            660                 665                 670         


Val Lys Phe Glu Glu Gln Gly Asp Phe Glu Ser Glu Lys Leu Trp Gln 
        675                 680                 685             


Arg Val Thr Arg Ala Ile Asn Ala Lys Asp Gln Thr Glu Ala Thr Gln 
    690                 695                 700                 


Glu Lys Tyr Val Leu Glu Glu Ala Gln Arg Gln Ala Ala Arg Asp Arg 
705                 710                 715                 720 


Lys Thr Lys Asn Glu Glu Trp Ser Cys Lys Leu Phe Glu Leu Asp Pro 
                725                 730                 735     


Leu Thr Gly Glu Trp His Tyr Lys Phe Ala Asp Thr Arg Pro Trp Asp 
            740                 745                 750         


Pro Leu Asn Asp Met Ile Gln Phe Glu Lys Asp Gly Val Ile Gln Thr 
        755                 760                 765             


Lys Val Lys His Arg Thr Pro Met Val Ser Val Pro Lys Met Lys His 
    770                 775                 780                 


Lys Pro Thr Arg Gln Gln Lys Lys Val Ala Lys Gly Tyr Ser Ser Pro 
785                 790                 795                 800 


Glu Pro Asp Ile Gln Asp Ser Ser Gly Ser Glu Ala Gln Ser Val Lys 
                805                 810                 815     


Pro Ser Thr Arg Arg Lys Lys Gly Ile Glu Leu Gly Asp Ile Gln Ser 
            820                 825                 830         


Ser Ile Glu Ser Ile Lys Gln Thr Gln Glu Glu Ile Lys Arg Asn Ile 
        835                 840                 845             


Met Ala Leu Arg Asn His Leu Val Ser Ser Thr Pro Ala Thr Asp Tyr 
    850                 855                 860                 


Phe Leu Gln Gln Lys Asp Tyr Phe Ile Ile Phe Leu Leu Ile Leu Leu 
865                 870                 875                 880 


Gln Val Ile Ile Asn Phe Met Phe Lys 
                885                 


<210>  4731
<211>  745
<212>  PRT
<213>  Homo sapiens

<400>  4731

Met Phe Pro Leu Arg Ala Leu Trp Leu Val Trp Ala Leu Leu Gly Val 
1               5                   10                  15      


Ala Gly Ser Cys Pro Glu Pro Cys Ala Cys Val Asp Lys Tyr Ala His 
            20                  25                  30          


Gln Phe Ala Asp Cys Ala Tyr Lys Glu Leu Arg Glu Val Pro Glu Gly 
        35                  40                  45              


Leu Pro Ala Asn Val Thr Thr Leu Ser Leu Ser Ala Asn Lys Ile Thr 
    50                  55                  60                  


Val Leu Arg Arg Gly Ala Phe Ala Asp Val Thr Gln Val Thr Ser Leu 
65                  70                  75                  80  


Trp Leu Ala His Asn Glu Val Arg Thr Val Glu Pro Gly Ala Leu Ala 
                85                  90                  95      


Val Leu Ser Gln Leu Lys Asn Leu Asp Leu Ser His Asn Phe Ile Ser 
            100                 105                 110         


Ser Phe Pro Trp Ser Asp Leu Arg Asn Leu Ser Ala Leu Gln Leu Leu 
        115                 120                 125             


Lys Met Asn His Asn Arg Leu Gly Ser Leu Pro Arg Asp Ala Leu Gly 
    130                 135                 140                 


Ala Leu Pro Asp Leu Arg Ser Leu Arg Ile Asn Asn Asn Arg Leu Arg 
145                 150                 155                 160 


Thr Leu Ala Pro Gly Thr Phe Asp Ala Leu Ser Ala Leu Ser His Leu 
                165                 170                 175     


Gln Leu Tyr His Asn Pro Phe His Cys Gly Cys Gly Leu Val Trp Leu 
            180                 185                 190         


Gln Ala Trp Ala Ala Ser Thr Arg Val Ser Leu Pro Glu Pro Asp Ser 
        195                 200                 205             


Ile Ala Cys Ala Ser Pro Pro Ala Leu Gln Gly Val Pro Val Tyr Arg 
    210                 215                 220                 


Leu Pro Ala Leu Pro Cys Ala Pro Pro Ser Val His Leu Ser Ala Glu 
225                 230                 235                 240 


Pro Pro Leu Glu Ala Pro Gly Thr Pro Leu Arg Ala Gly Leu Ala Phe 
                245                 250                 255     


Val Leu His Cys Ile Ala Asp Gly His Pro Thr Pro Arg Leu Gln Trp 
            260                 265                 270         


Gln Leu Gln Ile Pro Gly Gly Thr Val Val Leu Glu Pro Pro Val Leu 
        275                 280                 285             


Ser Gly Glu Asp Asp Gly Val Gly Ala Glu Glu Gly Glu Gly Glu Gly 
    290                 295                 300                 


Asp Gly Asp Leu Leu Thr Gln Thr Gln Ala Gln Thr Pro Thr Pro Ala 
305                 310                 315                 320 


Pro Ala Trp Pro Ala Pro Pro Ala Thr Pro Arg Phe Leu Ala Leu Ala 
                325                 330                 335     


Asn Gly Ser Leu Leu Val Pro Leu Leu Ser Ala Lys Glu Ala Gly Val 
            340                 345                 350         


Tyr Thr Cys Arg Ala His Asn Glu Leu Gly Ala Asn Ser Thr Ser Ile 
        355                 360                 365             


Arg Val Ala Val Ala Ala Thr Gly Pro Pro Lys His Ala Pro Gly Ala 
    370                 375                 380                 


Gly Gly Glu Pro Asp Gly Gln Ala Pro Thr Ser Glu Arg Lys Ser Thr 
385                 390                 395                 400 


Ala Lys Gly Arg Gly Asn Ser Val Leu Pro Ser Lys Pro Glu Gly Lys 
                405                 410                 415     


Ile Lys Gly Gln Gly Leu Ala Lys Val Ser Ile Leu Gly Glu Thr Glu 
            420                 425                 430         


Thr Glu Pro Glu Glu Asp Thr Ser Glu Gly Glu Glu Ala Glu Asp Gln 
        435                 440                 445             


Ile Leu Ala Asp Pro Ala Glu Glu Gln Arg Cys Gly Asn Gly Asp Pro 
    450                 455                 460                 


Ser Arg Tyr Val Ser Asn His Ala Phe Asn Gln Ser Ala Glu Leu Lys 
465                 470                 475                 480 


Pro His Val Phe Glu Leu Gly Val Ile Ala Leu Asp Val Ala Glu Arg 
                485                 490                 495     


Glu Ala Arg Val Gln Leu Thr Pro Leu Ala Ala Arg Trp Gly Pro Gly 
            500                 505                 510         


Pro Gly Gly Ala Gly Gly Ala Pro Arg Pro Gly Arg Arg Pro Leu Arg 
        515                 520                 525             


Leu Leu Tyr Leu Cys Pro Ala Gly Gly Gly Ala Ala Val Gln Trp Ser 
    530                 535                 540                 


Arg Val Glu Glu Gly Val Asn Ala Tyr Trp Phe Arg Gly Leu Arg Pro 
545                 550                 555                 560 


Gly Thr Asn Tyr Ser Val Cys Leu Ala Leu Ala Gly Glu Ala Cys His 
                565                 570                 575     


Val Gln Val Val Phe Ser Thr Lys Lys Glu Leu Pro Ser Leu Leu Val 
            580                 585                 590         


Ile Val Ala Val Ser Val Phe Leu Leu Val Leu Ala Thr Val Pro Leu 
        595                 600                 605             


Leu Gly Ala Ala Cys Cys His Leu Leu Ala Lys His Pro Gly Lys Pro 
    610                 615                 620                 


Tyr Arg Leu Ile Leu Arg Pro Gln Ala Pro Asp Pro Met Glu Lys Arg 
625                 630                 635                 640 


Ile Ala Ala Asp Phe Asp Pro Arg Ala Ser Tyr Leu Glu Ser Glu Lys 
                645                 650                 655     


Ser Tyr Pro Ala Gly Gly Glu Ala Gly Gly Glu Glu Pro Glu Asp Val 
            660                 665                 670         


Gln Gly Glu Gly Leu Asp Glu Asp Ala Glu Gln Gly Asp Pro Ser Gly 
        675                 680                 685             


Asp Leu Gln Arg Glu Glu Ser Leu Ala Ala Cys Ser Leu Val Glu Ser 
    690                 695                 700                 


Gln Ser Lys Ala Asn Gln Glu Glu Phe Glu Ala Gly Ser Glu Tyr Ser 
705                 710                 715                 720 


Asp Arg Leu Pro Leu Gly Ala Glu Ala Val Asn Ile Ala Gln Glu Ile 
                725                 730                 735     


Asn Gly Asn Tyr Arg Gln Thr Ala Gly 
            740                 745 


<210>  4732
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  4732

Met Ala Thr Val Leu Ser Arg Ala Leu Lys Leu Pro Gly Lys Lys Ser 
1               5                   10                  15      


Pro Asp Leu Gly Glu Tyr Asp Pro Leu Thr Gln Ala Asp Ser Asp Glu 
            20                  25                  30          


Ser Glu Asp Asp Leu Val Leu Asn Leu Gln Lys Asn Gly Gly Val Lys 
        35                  40                  45              


Asn Gly Lys Ser Pro Leu Gly Glu Ala Pro Glu Pro Asp Ser Asp Ala 
    50                  55                  60                  


Glu Val Ala Glu Ala Ala Lys Pro His Leu Ser Glu Val Thr Thr Glu 
65                  70                  75                  80  


Gly Tyr Pro Ser Glu Pro Leu Gly Gly Leu Glu Gln Lys Ala Ala Ser 
                85                  90                  95      


Ser Leu Val Ser Tyr Val Arg Thr Ser Val Phe Leu Leu Thr Leu Gly 
            100                 105                 110         


Ile Ser Met Ile Leu Val Leu Leu Cys Ala Phe Leu Ile Pro Cys Pro 
        115                 120                 125             


Pro Arg Asp Leu His Ser Thr Trp Ser Arg His Leu Gly Ser Gln Gly 
    130                 135                 140                 


Gly Gly Asp Leu Ser Pro Leu Glu Leu Ala Asp Val Asn Gly Asp Gly 
145                 150                 155                 160 


Leu Arg Asp Val Leu Leu Ser Phe Val Met Ser Arg Asn Gly Ser Ala 
                165                 170                 175     


Val Gly Val Ser Arg Pro Ala Ala Asn Leu Val Cys Leu Ser Gly Met 
            180                 185                 190         


Asn Gly Ser Thr Leu Trp Ser Ser Leu Leu Pro Glu Glu Ala Arg Asp 
        195                 200                 205             


Ile Thr Cys Leu Glu Leu Met Pro Gly Ser Leu Ala Glu Thr Ile Cys 
    210                 215                 220                 


Leu Val Thr Gly Thr His Lys Met Leu Ser Ala Phe Asn Ala Thr Ser 
225                 230                 235                 240 


Gly Lys Ala Ile Trp Thr Leu Asn Pro Asn Tyr Leu Ser Asn Gly Thr 
                245                 250                 255     


Leu Ala Ala Pro Val Val Val Leu Pro Asp Leu Asp Glu Asp Gly Val 
            260                 265                 270         


Arg Asp Leu Val Val Leu Ala Ile Gly Glu Leu Gln Pro Asp Leu Cys 
        275                 280                 285             


Phe Leu Leu Val Ser Gly Arg Thr Gly Asn Pro Val Gly Arg Pro Val 
    290                 295                 300                 


Lys Tyr Asn Ile Val Gly Val Gly Asn Leu Ile Gly Pro Gln Val Tyr 
305                 310                 315                 320 


Ile Thr Thr Asn Gly Ala Val Tyr Ile Leu Phe Gly Phe Gly Asn Ile 
                325                 330                 335     


Gln Ala Val Ala Leu Arg Asp Ile Phe Val Gln Ala Gln Asn Arg Asp 
            340                 345                 350         


Ser Ser Pro Pro Ser Leu Gln Ile Glu Glu Pro Glu Trp Glu Lys Arg 
        355                 360                 365             


Arg Ser Ile Asn Leu Ser Glu Leu Ile Asp Val Tyr Ser Asp Gly Val 
    370                 375                 380                 


Glu Leu Leu Gln Met Val Lys Ala Pro Asp Ser Asn Cys Ser Asn Leu 
385                 390                 395                 400 


Leu Ile Thr Thr Arg Gln Ser Leu Val Leu Leu Arg Gly Gln Asn Leu 
                405                 410                 415     


Thr Pro Tyr Trp Ala Leu Arg Leu Gln Gly Leu Arg Ser Gln Pro Thr 
            420                 425                 430         


Pro Gly Tyr Phe Thr Asp Asp Gln Thr Leu Asp Phe Leu Leu Gln Ile 
        435                 440                 445             


Gln Asp Gly Val Gly Met Lys Lys Met Met Val Val Asp Gly Asp Ser 
    450                 455                 460                 


Gly Ser Ile Val Trp Ser Tyr Arg Ala Pro Cys His Met Lys Glu Thr 
465                 470                 475                 480 


Pro Ala Thr Ser Ala Val Thr Ser Asp Gln Lys Ser Val Phe Leu Phe 
                485                 490                 495     


Trp Ala Glu Gly Leu Ser Ala Ala Ser Pro Asn Ser Asp Ile Ile Leu 
            500                 505                 510         


Gly Thr Glu Pro Pro Ser Leu His His Leu Tyr Leu Leu His Pro Ala 
        515                 520                 525             


Phe Pro Ser Ile Leu Leu Asp Leu Ala Asn Thr Thr Gly Thr Val Thr 
    530                 535                 540                 


Ala Ser Glu Val Gly Ile Asn Asp Leu Trp Lys Asp Ala Phe Tyr Val 
545                 550                 555                 560 


Thr Arg Thr Thr Gly Pro Ser Ser Glu Gly His Pro Ala Ala Leu Val 
                565                 570                 575     


Val Ser Lys Leu Ser Leu Arg Trp Ala Leu Met Glu Gly Gln Met Ala 
            580                 585                 590         


Gln Leu Gln Glu Ser Thr Pro Lys Ile Gly Arg Gly Glu Leu Arg Arg 
        595                 600                 605             


Phe Leu Ser Arg Ile Lys Phe Val Glu Ala Pro Tyr Glu Ile 
    610                 615                 620         


<210>  4733
<211>  1011
<212>  PRT
<213>  Homo sapiens

<400>  4733

Met Arg Val Phe Leu Leu Cys Ala Tyr Ile Leu Leu Leu Met Val Ser 
1               5                   10                  15      


Gln Leu Arg Ala Val Ser Phe Pro Glu Asp Asp Glu Pro Leu Asn Thr 
            20                  25                  30          


Val Asp Tyr His Tyr Ser Arg Gln Tyr Pro Val Phe Arg Gly Arg Pro 
        35                  40                  45              


Ser Gly Asn Glu Ser Gln His Arg Leu Asp Phe Gln Leu Met Leu Lys 
    50                  55                  60                  


Ile Arg Asp Thr Leu Tyr Ile Ala Gly Arg Asp Gln Val Tyr Thr Val 
65                  70                  75                  80  


Asn Leu Asn Glu Met Pro Lys Thr Glu Val Ile Pro Asn Lys Lys Leu 
                85                  90                  95      


Thr Trp Arg Ser Arg Gln Gln Asp Arg Glu Asn Cys Ala Met Lys Gly 
            100                 105                 110         


Lys His Lys Asp Glu Cys His Asn Phe Ile Lys Val Phe Val Pro Arg 
        115                 120                 125             


Asn Asp Glu Met Val Phe Val Cys Gly Thr Asn Ala Phe Asn Pro Met 
    130                 135                 140                 


Cys Arg Tyr Tyr Arg Leu Ser Thr Leu Glu Tyr Asp Gly Glu Glu Ile 
145                 150                 155                 160 


Ser Gly Leu Ala Arg Cys Pro Phe Asp Ala Arg Gln Thr Asn Val Ala 
                165                 170                 175     


Leu Phe Ala Asp Gly Lys Leu Tyr Ser Ala Thr Val Ala Asp Phe Leu 
            180                 185                 190         


Ala Ser Asp Ala Val Ile Tyr Arg Ser Met Gly Asp Gly Ser Ala Leu 
        195                 200                 205             


Arg Thr Ile Lys Tyr Asp Ser Lys Trp Ile Lys Glu Pro His Phe Leu 
    210                 215                 220                 


His Ala Ile Glu Tyr Gly Asn Tyr Val Tyr Phe Phe Phe Arg Glu Ile 
225                 230                 235                 240 


Ala Val Glu His Asn Asn Leu Gly Lys Ala Val Tyr Ser Arg Val Ala 
                245                 250                 255     


Arg Ile Cys Lys Asn Asp Met Gly Gly Ser Gln Arg Val Leu Glu Lys 
            260                 265                 270         


His Trp Thr Ser Phe Leu Lys Ala Arg Leu Asn Cys Ser Val Pro Gly 
        275                 280                 285             


Asp Ser Phe Phe Tyr Phe Asp Val Leu Gln Ser Ile Thr Asp Ile Ile 
    290                 295                 300                 


Gln Ile Asn Gly Ile Pro Thr Val Val Gly Val Phe Thr Thr Gln Leu 
305                 310                 315                 320 


Asn Ser Ile Pro Gly Ser Ala Val Cys Ala Phe Ser Met Asp Asp Ile 
                325                 330                 335     


Glu Lys Val Phe Lys Gly Arg Phe Lys Glu Gln Lys Thr Pro Asp Ser 
            340                 345                 350         


Val Trp Thr Ala Val Pro Glu Asp Lys Val Pro Lys Pro Arg Pro Gly 
        355                 360                 365             


Cys Cys Ala Lys His Gly Leu Ala Glu Ala Tyr Lys Thr Ser Ile Asp 
    370                 375                 380                 


Phe Pro Asp Glu Thr Leu Ser Phe Ile Lys Ser His Pro Leu Met Asp 
385                 390                 395                 400 


Ser Ala Val Pro Pro Ile Ala Asp Glu Pro Trp Phe Thr Lys Thr Arg 
                405                 410                 415     


Val Arg Tyr Arg Leu Thr Ala Ile Ser Val Asp His Ser Ala Gly Pro 
            420                 425                 430         


Tyr Gln Asn Tyr Thr Val Ile Phe Val Gly Ser Glu Ala Gly Met Val 
        435                 440                 445             


Leu Lys Val Leu Ala Lys Thr Ser Pro Phe Ser Leu Asn Asp Ser Val 
    450                 455                 460                 


Leu Leu Glu Glu Ile Glu Ala Tyr Asn His Ala Lys Cys Ser Ala Glu 
465                 470                 475                 480 


Asn Glu Glu Asp Lys Lys Val Ile Ser Leu Gln Leu Asp Lys Asp His 
                485                 490                 495     


His Ala Leu Tyr Val Ala Phe Ser Ser Cys Ile Ile Arg Ile Pro Leu 
            500                 505                 510         


Ser Arg Cys Glu Arg Tyr Gly Ser Cys Lys Lys Ser Cys Ile Ala Ser 
        515                 520                 525             


Arg Asp Pro Tyr Cys Gly Trp Leu Ser Gln Gly Ser Cys Gly Arg Val 
    530                 535                 540                 


Thr Pro Gly Met Leu Leu Leu Thr Glu Asp Phe Phe Ala Phe His Asn 
545                 550                 555                 560 


His Ser Ala Glu Gly Tyr Glu Gln Asp Thr Glu Phe Gly Asn Thr Ala 
                565                 570                 575     


His Leu Gly Asp Cys His Gly Val Arg Trp Glu Val Gln Ser Gly Glu 
            580                 585                 590         


Ser Asn Gln Met Val His Met Asn Val Leu Ile Thr Cys Val Phe Ala 
        595                 600                 605             


Ala Phe Val Leu Gly Ala Phe Ile Ala Gly Val Ala Val Tyr Cys Tyr 
    610                 615                 620                 


Arg Asp Met Phe Val Arg Lys Asn Arg Lys Ile His Lys Asp Ala Glu 
625                 630                 635                 640 


Ser Ala Gln Ser Cys Thr Asp Ser Ser Gly Ser Phe Ala Lys Leu Asn 
                645                 650                 655     


Gly Leu Phe Asp Ser Pro Val Lys Glu Tyr Gln Gln Asn Ile Asp Ser 
            660                 665                 670         


Pro Lys Leu Tyr Ser Asn Leu Leu Thr Ser Arg Lys Glu Leu Pro Pro 
        675                 680                 685             


Asn Gly Asp Thr Lys Ser Met Val Met Asp His Arg Gly Gln Pro Pro 
    690                 695                 700                 


Glu Leu Ala Ala Leu Pro Thr Pro Glu Ser Thr Pro Val Leu His Gln 
705                 710                 715                 720 


Lys Thr Leu Gln Ala Met Lys Ser His Ser Glu Lys Ala His Gly His 
                725                 730                 735     


Gly Ala Ser Arg Lys Glu Thr Pro Gln Phe Phe Pro Ser Ser Pro Pro 
            740                 745                 750         


Pro His Ser Pro Leu Ser His Gly His Ile Pro Ser Ala Ile Val Leu 
        755                 760                 765             


Pro Asn Ala Thr His Asp Tyr Asn Thr Ser Phe Ser Asn Ser Asn Ala 
    770                 775                 780                 


His Lys Ala Glu Lys Lys Leu Gln Asn Ile Asp His Pro Leu Thr Lys 
785                 790                 795                 800 


Ser Ser Ser Lys Arg Asp His Arg Arg Ser Val Asp Ser Arg Asn Thr 
                805                 810                 815     


Leu Asn Asp Leu Leu Lys His Leu Asn Asp Pro Asn Ser Asn Pro Lys 
            820                 825                 830         


Ala Ile Met Gly Asp Ile Gln Met Ala His Gln Asn Leu Met Leu Asp 
        835                 840                 845             


Pro Met Gly Ser Met Ser Glu Val Pro Pro Lys Val Pro Asn Arg Glu 
    850                 855                 860                 


Ala Ser Leu Tyr Ser Pro Pro Ser Thr Leu Pro Arg Asn Ser Pro Thr 
865                 870                 875                 880 


Lys Arg Val Asp Val Pro Thr Thr Pro Gly Val Pro Met Thr Ser Leu 
                885                 890                 895     


Glu Arg Gln Arg Gly Tyr His Lys Asn Ser Ser Gln Arg His Ser Ile 
            900                 905                 910         


Ser Ala Met Pro Lys Asn Leu Asn Ser Pro Asn Gly Val Leu Leu Ser 
        915                 920                 925             


Arg Gln Pro Ser Met Asn Arg Gly Gly Tyr Met Pro Thr Pro Thr Gly 
    930                 935                 940                 


Ala Lys Val Asp Tyr Ile Gln Gly Thr Pro Val Ser Val His Leu Gln 
945                 950                 955                 960 


Pro Ser Leu Ser Arg Gln Ser Ser Tyr Thr Ser Asn Gly Thr Leu Pro 
                965                 970                 975     


Arg Thr Gly Leu Lys Arg Thr Pro Ser Leu Lys Pro Asp Val Pro Pro 
            980                 985                 990         


Lys Pro Ser Phe Val Pro Gln Thr  Pro Ser Val Arg Pro  Leu Asn Lys 
        995                 1000                 1005             


Tyr Thr  Tyr 
    1010     


<210>  4734
<211>  746
<212>  PRT
<213>  Homo sapiens

<400>  4734

Met Leu Val Leu Gly Leu Leu Val Ala Gly Ala Ala Asp Gly Cys Glu 
1               5                   10                  15      


Leu Val Pro Arg His Leu Arg Gly Arg Arg Ala Thr Gly Ser Ala Ala 
            20                  25                  30          


Thr Ala Ala Ser Ser Pro Ala Ala Ala Ala Gly Asp Ser Pro Ala Leu 
        35                  40                  45              


Met Thr Asp Pro Cys Met Ser Leu Ser Pro Pro Cys Phe Thr Glu Glu 
    50                  55                  60                  


Asp Arg Phe Ser Leu Glu Ala Leu Gln Thr Ile His Lys Gln Met Asp 
65                  70                  75                  80  


Asp Asp Lys Asp Gly Gly Ile Glu Val Glu Glu Ser Asp Glu Phe Ile 
                85                  90                  95      


Arg Glu Asp Met Lys Tyr Lys Asp Ala Thr Asn Lys His Ser His Leu 
            100                 105                 110         


His Arg Glu Asp Lys His Ile Thr Ile Glu Asp Leu Trp Lys Arg Trp 
        115                 120                 125             


Lys Thr Ser Glu Val His Asn Trp Thr Leu Glu Asp Thr Leu Gln Trp 
    130                 135                 140                 


Leu Ile Glu Phe Val Glu Leu Pro Gln Tyr Glu Lys Asn Phe Arg Asp 
145                 150                 155                 160 


Asn Asn Val Lys Gly Thr Thr Leu Pro Arg Ile Ala Val His Glu Pro 
                165                 170                 175     


Ser Phe Met Ile Ser Gln Leu Lys Ile Ser Asp Arg Ser His Arg Gln 
            180                 185                 190         


Lys Leu Gln Leu Lys Ala Leu Asp Val Val Leu Phe Gly Pro Leu Thr 
        195                 200                 205             


Arg Pro Pro His Asn Trp Met Lys Asp Phe Ile Leu Thr Val Ser Ile 
    210                 215                 220                 


Val Ile Gly Val Gly Gly Cys Trp Phe Ala Tyr Thr Gln Asn Lys Thr 
225                 230                 235                 240 


Ser Lys Glu His Val Ala Lys Met Met Lys Asp Leu Glu Ser Leu Gln 
                245                 250                 255     


Thr Ala Glu Gln Ser Leu Met Asp Leu Gln Glu Arg Leu Glu Lys Ala 
            260                 265                 270         


Gln Glu Glu Asn Arg Asn Val Ala Val Glu Lys Gln Asn Leu Glu Arg 
        275                 280                 285             


Lys Met Met Asp Glu Ile Asn Tyr Ala Lys Glu Glu Ala Cys Arg Leu 
    290                 295                 300                 


Arg Glu Leu Arg Glu Gly Ala Glu Cys Glu Leu Ser Arg Arg Gln Tyr 
305                 310                 315                 320 


Ala Glu Gln Glu Leu Glu Gln Val Arg Met Ala Leu Lys Lys Ala Glu 
                325                 330                 335     


Lys Glu Phe Glu Leu Arg Ser Ser Trp Ser Val Pro Asp Ala Leu Gln 
            340                 345                 350         


Lys Trp Leu Gln Leu Thr His Glu Val Glu Val Gln Tyr Tyr Asn Ile 
        355                 360                 365             


Lys Arg Gln Asn Ala Glu Met Gln Leu Ala Ile Ala Lys Asp Glu Ala 
    370                 375                 380                 


Glu Lys Ile Lys Lys Lys Arg Ser Thr Val Phe Gly Thr Leu His Val 
385                 390                 395                 400 


Ala His Ser Ser Ser Leu Asp Glu Val Asp His Lys Ile Leu Glu Ala 
                405                 410                 415     


Lys Lys Ala Leu Ser Glu Leu Thr Thr Cys Leu Arg Glu Arg Leu Phe 
            420                 425                 430         


Arg Trp Gln Gln Ile Glu Lys Ile Cys Gly Phe Gln Ile Ala His Asn 
        435                 440                 445             


Ser Gly Leu Pro Ser Leu Thr Ser Ser Leu Tyr Ser Asp His Ser Trp 
    450                 455                 460                 


Val Val Met Pro Arg Val Ser Ile Pro Pro Tyr Pro Ile Ala Gly Gly 
465                 470                 475                 480 


Val Asp Asp Leu Asp Glu Asp Thr Pro Pro Ile Val Ser Gln Phe Pro 
                485                 490                 495     


Gly Thr Met Ala Lys Pro Pro Gly Ser Leu Ala Arg Ser Ser Ser Leu 
            500                 505                 510         


Cys Arg Ser Arg Arg Ser Ile Val Pro Ser Ser Pro Gln Pro Gln Arg 
        515                 520                 525             


Ala Gln Leu Ala Pro His Ala Pro His Pro Ser His Pro Arg His Pro 
    530                 535                 540                 


His His Pro Gln His Thr Pro His Ser Leu Pro Ser Pro Asp Pro Asp 
545                 550                 555                 560 


Ile Leu Ser Val Ser Ser Cys Pro Ala Leu Tyr Arg Asn Glu Glu Glu 
                565                 570                 575     


Glu Glu Ala Ile Tyr Phe Ser Ala Glu Lys Gln Trp Glu Val Pro Asp 
            580                 585                 590         


Thr Ala Ser Glu Cys Asp Ser Leu Asn Ser Ser Ile Gly Arg Lys Gln 
        595                 600                 605             


Ser Pro Pro Leu Ser Leu Glu Ile Tyr Gln Thr Leu Ser Pro Arg Lys 
    610                 615                 620                 


Ile Ser Arg Asp Glu Val Ser Leu Glu Asp Ser Ser Arg Gly Asp Ser 
625                 630                 635                 640 


Pro Val Thr Val Asp Val Ser Trp Gly Ser Pro Asp Cys Val Gly Leu 
                645                 650                 655     


Thr Glu Thr Lys Ser Met Ile Phe Ser Pro Ala Ser Lys Val Tyr Asn 
            660                 665                 670         


Gly Ile Leu Glu Lys Ser Cys Ser Met Asn Gln Leu Ser Ser Gly Ile 
        675                 680                 685             


Pro Val Pro Lys Pro Arg His Thr Ser Cys Ser Ser Ala Gly Asn Asp 
    690                 695                 700                 


Ser Lys Pro Val Gln Glu Ala Pro Ser Val Ala Arg Ile Ser Ser Ile 
705                 710                 715                 720 


Pro His Asp Leu Cys His Asn Gly Glu Lys Ser Lys Lys Pro Ser Lys 
                725                 730                 735     


Ile Lys Ser Leu Phe Lys Lys Lys Ser Lys 
            740                 745     


<210>  4735
<211>  771
<212>  PRT
<213>  Homo sapiens

<400>  4735

Met Ala Pro Gly Pro Phe Ser Ser Ala Leu Leu Ser Pro Pro Pro Ala 
1               5                   10                  15      


Ala Leu Pro Phe Leu Leu Leu Leu Trp Ala Gly Ala Ser Arg Gly Gln 
            20                  25                  30          


Pro Cys Pro Gly Arg Cys Ile Cys Gln Asn Val Ala Pro Thr Leu Thr 
        35                  40                  45              


Met Leu Cys Ala Lys Thr Gly Leu Leu Phe Val Pro Pro Ala Ile Asp 
    50                  55                  60                  


Arg Arg Val Val Glu Leu Arg Leu Thr Asp Asn Phe Ile Ala Ala Val 
65                  70                  75                  80  


Arg Arg Arg Asp Phe Ala Asn Met Thr Ser Leu Val His Leu Thr Leu 
                85                  90                  95      


Ser Arg Asn Thr Ile Gly Gln Val Ala Ala Gly Ala Phe Ala Asp Leu 
            100                 105                 110         


Arg Ala Leu Arg Ala Leu His Leu Asp Ser Asn Arg Leu Ala Glu Val 
        115                 120                 125             


Arg Gly Asp Gln Leu Arg Gly Leu Gly Asn Leu Arg His Leu Ile Leu 
    130                 135                 140                 


Gly Asn Asn Gln Ile Arg Arg Val Glu Ser Ala Ala Phe Asp Ala Phe 
145                 150                 155                 160 


Leu Ser Thr Val Glu Asp Leu Asp Leu Ser Tyr Asn Asn Leu Glu Ala 
                165                 170                 175     


Leu Pro Trp Glu Ala Val Gly Gln Met Val Asn Leu Asn Thr Leu Thr 
            180                 185                 190         


Leu Asp His Asn Leu Ile Asp His Ile Ala Glu Gly Thr Phe Val Gln 
        195                 200                 205             


Leu His Lys Leu Val Arg Leu Asp Met Thr Ser Asn Arg Leu His Lys 
    210                 215                 220                 


Leu Pro Pro Asp Gly Leu Phe Leu Arg Ser Gln Gly Thr Gly Pro Lys 
225                 230                 235                 240 


Pro Pro Thr Pro Leu Thr Val Ser Phe Gly Gly Asn Pro Leu His Cys 
                245                 250                 255     


Asn Cys Glu Leu Leu Trp Leu Arg Arg Leu Thr Arg Glu Asp Asp Leu 
            260                 265                 270         


Glu Thr Cys Ala Thr Pro Glu His Leu Thr Asp Arg Tyr Phe Trp Ser 
        275                 280                 285             


Ile Pro Glu Glu Glu Phe Leu Cys Glu Pro Pro Leu Ile Thr Arg Gln 
    290                 295                 300                 


Ala Gly Gly Arg Ala Leu Val Val Glu Gly Gln Ala Val Ser Leu Arg 
305                 310                 315                 320 


Cys Arg Ala Val Gly Asp Pro Glu Pro Val Val His Trp Val Ala Pro 
                325                 330                 335     


Asp Gly Arg Leu Leu Gly Asn Ser Ser Arg Thr Arg Val Arg Gly Asp 
            340                 345                 350         


Gly Thr Leu Asp Val Thr Ile Thr Thr Leu Arg Asp Ser Gly Thr Phe 
        355                 360                 365             


Thr Cys Ile Ala Ser Asn Ala Ala Gly Glu Ala Thr Ala Pro Val Glu 
    370                 375                 380                 


Val Cys Val Val Pro Leu Pro Leu Met Ala Pro Pro Pro Ala Ala Pro 
385                 390                 395                 400 


Pro Pro Leu Thr Glu Pro Gly Ser Ser Asp Ile Ala Thr Pro Gly Arg 
                405                 410                 415     


Pro Gly Ala Asn Asp Ser Ala Ala Glu Arg Arg Leu Val Ala Ala Glu 
            420                 425                 430         


Leu Thr Ser Asn Ser Val Leu Ile Arg Trp Pro Ala Gln Arg Pro Val 
        435                 440                 445             


Pro Gly Ile Arg Met Tyr Gln Val Gln Tyr Asn Ser Ser Val Asp Asp 
    450                 455                 460                 


Ser Leu Val Tyr Arg Met Ile Pro Ser Thr Ser Gln Thr Phe Leu Val 
465                 470                 475                 480 


Asn Asp Leu Ala Ala Gly Arg Ala Tyr Asp Leu Cys Val Leu Ala Val 
                485                 490                 495     


Tyr Asp Asp Gly Ala Thr Ala Leu Pro Ala Thr Arg Val Val Gly Cys 
            500                 505                 510         


Val Gln Phe Thr Thr Ala Gly Asp Pro Ala Pro Cys Arg Pro Leu Arg 
        515                 520                 525             


Ala His Phe Leu Gly Gly Thr Met Ile Ile Ala Ile Gly Gly Val Ile 
    530                 535                 540                 


Val Ala Ser Val Leu Val Phe Ile Val Leu Leu Met Ile Arg Tyr Lys 
545                 550                 555                 560 


Val Tyr Gly Asp Gly Asp Ser Arg Arg Val Lys Gly Ser Arg Ser Leu 
                565                 570                 575     


Pro Arg Val Ser His Val Cys Ser Gln Thr Asn Gly Ala Gly Thr Gly 
            580                 585                 590         


Ala Ala Gln Ala Pro Ala Leu Pro Ala Gln Asp His Tyr Glu Ala Leu 
        595                 600                 605             


Arg Glu Val Glu Ser Gln Ala Ala Pro Ala Val Ala Val Glu Ala Lys 
    610                 615                 620                 


Ala Met Glu Ala Glu Thr Ala Ser Ala Glu Pro Glu Val Val Leu Gly 
625                 630                 635                 640 


Arg Ser Leu Gly Gly Ser Ala Thr Ser Leu Cys Leu Leu Pro Ser Glu 
                645                 650                 655     


Glu Thr Ser Gly Glu Glu Ser Arg Ala Ala Val Gly Pro Arg Arg Ser 
            660                 665                 670         


Arg Ser Gly Ala Leu Glu Pro Pro Thr Ser Ala Pro Pro Thr Leu Ala 
        675                 680                 685             


Leu Val Pro Gly Gly Ala Ala Ala Arg Pro Arg Pro Gln Gln Arg Tyr 
    690                 695                 700                 


Ser Phe Asp Gly Asp Tyr Gly Ala Leu Phe Gln Ser His Ser Tyr Pro 
705                 710                 715                 720 


Arg Arg Ala Arg Arg Thr Lys Arg His Arg Ser Thr Pro His Leu Asp 
                725                 730                 735     


Gly Ala Gly Gly Gly Ala Ala Gly Glu Asp Gly Asp Leu Gly Leu Gly 
            740                 745                 750         


Ser Ala Arg Ala Cys Leu Ala Phe Thr Ser Thr Glu Trp Met Leu Glu 
        755                 760                 765             


Ser Thr Val 
    770     


<210>  4736
<211>  796
<212>  PRT
<213>  Homo sapiens

<400>  4736

Met Asn Gln Thr Ala Ser Val Ser His His Ile Lys Cys Gln Pro Ser 
1               5                   10                  15      


Lys Thr Ile Lys Glu Leu Gly Ser Asn Ser Pro Pro Gln Arg Asn Trp 
            20                  25                  30          


Lys Gly Ile Ala Ile Ala Leu Leu Val Ile Leu Val Val Cys Ser Leu 
        35                  40                  45              


Ile Thr Met Ser Val Ile Leu Leu Thr Pro Asp Glu Leu Thr Asn Ser 
    50                  55                  60                  


Ser Glu Thr Arg Leu Ser Leu Glu Asp Leu Phe Arg Lys Asp Phe Val 
65                  70                  75                  80  


Leu His Asp Pro Glu Ala Arg Trp Ile Asn Asp Thr Asp Val Val Tyr 
                85                  90                  95      


Lys Ser Glu Asn Gly His Val Ile Lys Leu Asn Ile Glu Thr Asn Ala 
            100                 105                 110         


Thr Thr Leu Leu Leu Glu Asn Thr Thr Phe Val Thr Phe Lys Ala Ser 
        115                 120                 125             


Arg His Ser Val Ser Pro Asp Leu Lys Tyr Val Leu Leu Ala Tyr Asp 
    130                 135                 140                 


Val Lys Gln Ile Phe His Tyr Ser Tyr Thr Ala Ser Tyr Val Ile Tyr 
145                 150                 155                 160 


Asn Ile His Thr Arg Glu Val Trp Glu Leu Asn Pro Pro Glu Val Glu 
                165                 170                 175     


Asp Ser Val Leu Gln Tyr Ala Ala Trp Gly Val Gln Gly Gln Gln Leu 
            180                 185                 190         


Ile Tyr Ile Phe Glu Asn Asn Ile Tyr Tyr Gln Pro Asp Ile Lys Ser 
        195                 200                 205             


Ser Ser Leu Arg Leu Thr Ser Ser Gly Lys Glu Glu Ile Ile Phe Asn 
    210                 215                 220                 


Gly Ile Ala Asp Trp Leu Tyr Glu Glu Glu Leu Leu His Ser His Ile 
225                 230                 235                 240 


Ala His Trp Trp Ser Pro Asp Gly Glu Arg Leu Ala Phe Leu Met Ile 
                245                 250                 255     


Asn Asp Ser Leu Val Pro Thr Met Val Ile Pro Arg Phe Thr Gly Ala 
            260                 265                 270         


Leu Tyr Pro Lys Gly Lys Gln Tyr Pro Tyr Pro Lys Ala Gly Gln Val 
        275                 280                 285             


Asn Pro Thr Ile Lys Leu Tyr Val Val Asn Leu Tyr Gly Pro Thr His 
    290                 295                 300                 


Thr Leu Glu Leu Met Pro Pro Asp Ser Phe Lys Ser Arg Glu Tyr Tyr 
305                 310                 315                 320 


Ile Thr Met Val Lys Trp Val Ser Asn Thr Lys Thr Val Val Arg Trp 
                325                 330                 335     


Leu Asn Arg Ala Gln Asn Ile Ser Ile Leu Thr Val Cys Glu Thr Thr 
            340                 345                 350         


Thr Gly Ala Cys Ser Lys Lys Tyr Glu Met Thr Ser Asp Thr Trp Leu 
        355                 360                 365             


Ser Gln Gln Asn Glu Glu Pro Val Phe Ser Arg Asp Gly Ser Lys Phe 
    370                 375                 380                 


Phe Met Thr Val Pro Val Lys Gln Gly Gly Arg Gly Glu Phe His His 
385                 390                 395                 400 


Ile Ala Met Phe Leu Ile Gln Ser Lys Ser Glu Gln Ile Thr Val Arg 
                405                 410                 415     


His Leu Thr Ser Gly Asn Trp Glu Val Ile Lys Ile Leu Ala Tyr Asp 
            420                 425                 430         


Glu Thr Thr Gln Lys Ile Tyr Phe Leu Ser Thr Glu Ser Ser Pro Arg 
        435                 440                 445             


Gly Arg Gln Leu Tyr Ser Ala Ser Thr Glu Gly Leu Leu Asn Arg Gln 
    450                 455                 460                 


Cys Ile Ser Cys Asn Phe Met Lys Glu Gln Cys Thr Tyr Phe Asp Ala 
465                 470                 475                 480 


Ser Phe Ser Pro Met Asn Gln His Phe Leu Leu Phe Cys Glu Gly Pro 
                485                 490                 495     


Arg Val Pro Val Val Ser Leu His Ser Thr Asp Asn Pro Ala Lys Tyr 
            500                 505                 510         


Phe Ile Leu Glu Ser Asn Ser Met Leu Lys Glu Ala Ile Leu Lys Lys 
        515                 520                 525             


Lys Ile Gly Lys Pro Glu Ile Lys Ile Leu His Ile Asp Asp Tyr Glu 
    530                 535                 540                 


Leu Pro Leu Gln Leu Ser Leu Pro Lys Asp Phe Met Asp Arg Asn Gln 
545                 550                 555                 560 


Tyr Ala Leu Leu Leu Ile Met Asp Glu Glu Pro Gly Gly Gln Leu Val 
                565                 570                 575     


Thr Asp Lys Phe His Ile Asp Trp Asp Ser Val Leu Ile Asp Met Asp 
            580                 585                 590         


Asn Val Ile Val Ala Arg Phe Asp Gly Arg Gly Ser Gly Phe Gln Gly 
        595                 600                 605             


Leu Lys Ile Leu Gln Glu Ile His Arg Arg Leu Gly Ser Val Glu Val 
    610                 615                 620                 


Lys Asp Gln Ile Thr Ala Val Lys Phe Leu Leu Lys Leu Pro Tyr Ile 
625                 630                 635                 640 


Asp Ser Lys Arg Leu Ser Ile Phe Gly Lys Gly Tyr Gly Gly Tyr Ile 
                645                 650                 655     


Ala Ser Met Ile Leu Lys Ser Asp Glu Lys Leu Phe Lys Cys Gly Ser 
            660                 665                 670         


Val Val Ala Pro Ile Thr Asp Leu Lys Leu Tyr Ala Ser Ala Phe Ser 
        675                 680                 685             


Glu Arg Tyr Leu Gly Met Pro Ser Lys Glu Glu Ser Thr Tyr Gln Ala 
    690                 695                 700                 


Ala Ser Val Leu His Asn Val His Gly Leu Lys Glu Glu Asn Ile Leu 
705                 710                 715                 720 


Ile Ile His Gly Thr Ala Asp Thr Lys Val His Phe Gln His Ser Ala 
                725                 730                 735     


Glu Leu Ile Lys His Leu Ile Lys Ala Gly Val Asn Tyr Thr Met Gln 
            740                 745                 750         


Val Tyr Pro Asp Glu Gly His Asn Val Ser Glu Lys Ser Lys Tyr His 
        755                 760                 765             


Leu Tyr Ser Thr Ile Leu Lys Phe Phe Ser Asp Cys Leu Lys Glu Glu 
    770                 775                 780                 


Ile Ser Val Leu Pro Gln Glu Pro Glu Glu Asp Glu 
785                 790                 795     


<210>  4737
<211>  716
<212>  PRT
<213>  Homo sapiens

<400>  4737

Met Ala Arg Met Ser Phe Val Ile Ala Ala Cys Gln Leu Val Leu Gly 
1               5                   10                  15      


Leu Leu Met Thr Ser Leu Thr Glu Ser Ser Ile Gln Asn Ser Glu Cys 
            20                  25                  30          


Pro Gln Leu Cys Val Cys Glu Ile Arg Pro Trp Phe Thr Pro Gln Ser 
        35                  40                  45              


Thr Tyr Arg Glu Ala Thr Thr Val Asp Cys Asn Asp Leu Arg Leu Thr 
    50                  55                  60                  


Arg Ile Pro Ser Asn Leu Ser Ser Asp Thr Gln Val Leu Leu Leu Gln 
65                  70                  75                  80  


Ser Asn Asn Ile Ala Lys Thr Val Asp Glu Leu Gln Gln Leu Phe Asn 
                85                  90                  95      


Leu Thr Glu Leu Asp Phe Ser Gln Asn Asn Phe Thr Asn Ile Lys Glu 
            100                 105                 110         


Val Gly Leu Ala Asn Leu Thr Gln Leu Thr Thr Leu His Leu Glu Glu 
        115                 120                 125             


Asn Gln Ile Thr Glu Met Thr Asp Tyr Cys Leu Gln Asp Leu Ser Asn 
    130                 135                 140                 


Leu Gln Glu Leu Tyr Ile Asn His Asn Gln Ile Ser Thr Ile Ser Ala 
145                 150                 155                 160 


His Ala Phe Ala Gly Leu Lys Asn Leu Leu Arg Leu His Leu Asn Ser 
                165                 170                 175     


Asn Lys Leu Lys Val Ile Asp Ser Arg Trp Phe Asp Ser Thr Pro Asn 
            180                 185                 190         


Leu Glu Ile Leu Met Ile Gly Glu Asn Pro Val Ile Gly Ile Leu Asp 
        195                 200                 205             


Met Asn Phe Lys Pro Leu Ala Asn Leu Arg Ser Leu Val Leu Ala Gly 
    210                 215                 220                 


Met Tyr Leu Thr Asp Ile Pro Gly Asn Ala Leu Val Gly Leu Asp Ser 
225                 230                 235                 240 


Leu Glu Ser Leu Ser Phe Tyr Asp Asn Lys Leu Val Lys Val Pro Gln 
                245                 250                 255     


Leu Ala Leu Gln Lys Val Pro Asn Leu Lys Phe Leu Asp Leu Asn Lys 
            260                 265                 270         


Asn Pro Ile His Lys Ile Gln Glu Gly Asp Phe Lys Asn Met Leu Arg 
        275                 280                 285             


Leu Lys Glu Leu Gly Ile Asn Asn Met Gly Glu Leu Val Ser Val Asp 
    290                 295                 300                 


Arg Tyr Ala Leu Asp Asn Leu Pro Glu Leu Thr Lys Leu Glu Ala Thr 
305                 310                 315                 320 


Asn Asn Pro Lys Leu Ser Tyr Ile His Arg Leu Ala Phe Arg Ser Val 
                325                 330                 335     


Pro Ala Leu Glu Ser Leu Met Leu Asn Asn Asn Ala Leu Asn Ala Ile 
            340                 345                 350         


Tyr Gln Lys Thr Val Glu Ser Leu Pro Asn Leu Arg Glu Ile Ser Ile 
        355                 360                 365             


His Ser Asn Pro Leu Arg Cys Asp Cys Val Ile His Trp Ile Asn Ser 
    370                 375                 380                 


Asn Lys Thr Asn Ile Arg Phe Met Glu Pro Leu Ser Met Phe Cys Ala 
385                 390                 395                 400 


Met Pro Pro Glu Tyr Lys Gly His Gln Val Lys Glu Val Leu Ile Gln 
                405                 410                 415     


Asp Ser Ser Glu Gln Cys Leu Pro Met Ile Ser His Asp Ser Phe Pro 
            420                 425                 430         


Asn Arg Leu Asn Val Asp Ile Gly Thr Thr Val Phe Leu Asp Cys Arg 
        435                 440                 445             


Ala Met Ala Glu Pro Glu Pro Glu Ile Tyr Trp Val Thr Pro Ile Gly 
    450                 455                 460                 


Asn Lys Ile Thr Val Glu Thr Leu Ser Asp Lys Tyr Lys Leu Ser Ser 
465                 470                 475                 480 


Glu Gly Thr Leu Glu Ile Ser Asn Ile Gln Ile Glu Asp Ser Gly Arg 
                485                 490                 495     


Tyr Thr Cys Val Ala Gln Asn Val Gln Gly Ala Asp Thr Arg Val Ala 
            500                 505                 510         


Thr Ile Lys Val Asn Gly Thr Leu Leu Asp Gly Thr Gln Val Leu Lys 
        515                 520                 525             


Ile Tyr Val Lys Gln Thr Glu Ser His Ser Ile Leu Val Ser Trp Lys 
    530                 535                 540                 


Val Asn Ser Asn Val Met Thr Ser Asn Leu Lys Trp Ser Ser Ala Thr 
545                 550                 555                 560 


Met Lys Ile Asp Asn Pro His Ile Thr Tyr Thr Ala Arg Val Pro Val 
                565                 570                 575     


Asp Val His Glu Tyr Asn Leu Thr His Leu Gln Pro Ser Thr Asp Tyr 
            580                 585                 590         


Glu Val Cys Leu Thr Val Ser Asn Ile His Gln Gln Thr Gln Lys Ser 
        595                 600                 605             


Cys Val Asn Val Thr Thr Lys Asn Ala Ala Phe Ala Val Asp Ile Ser 
    610                 615                 620                 


Asp Gln Glu Thr Ser Thr Ala Leu Ala Ala Val Met Gly Ser Met Phe 
625                 630                 635                 640 


Ala Val Ile Ser Leu Ala Ser Ile Ala Val Tyr Phe Ala Lys Arg Phe 
                645                 650                 655     


Lys Arg Lys Asn Tyr His His Ser Leu Lys Lys Tyr Met Gln Lys Thr 
            660                 665                 670         


Ser Ser Ile Pro Leu Asn Glu Leu Tyr Pro Pro Leu Ile Asn Leu Trp 
        675                 680                 685             


Glu Gly Asp Ser Glu Lys Asp Lys Asp Gly Ser Ala Asp Thr Lys Pro 
    690                 695                 700                 


Thr Gln Val Asp Thr Ser Arg Ser Tyr Tyr Met Trp 
705                 710                 715     


<210>  4738
<211>  774
<212>  PRT
<213>  Homo sapiens

<400>  4738

Met Glu Ala Glu Gln Arg Pro Ala Ala Gly Ala Ser Glu Gly Ala Thr 
1               5                   10                  15      


Pro Gly Leu Glu Ala Val Pro Pro Val Ala Pro Pro Pro Ala Thr Ala 
            20                  25                  30          


Ala Ser Gly Pro Ile Pro Lys Ser Gly Pro Glu Pro Lys Arg Arg His 
        35                  40                  45              


Leu Gly Thr Leu Leu Gln Pro Thr Val Asn Lys Phe Ser Leu Arg Val 
    50                  55                  60                  


Phe Gly Ser His Lys Ala Val Glu Ile Glu Gln Glu Arg Val Lys Ser 
65                  70                  75                  80  


Ala Gly Ala Trp Ile Ile His Pro Tyr Ser Asp Phe Arg Phe Tyr Trp 
                85                  90                  95      


Asp Leu Ile Met Leu Leu Leu Met Val Gly Asn Leu Ile Val Leu Pro 
            100                 105                 110         


Val Gly Ile Thr Phe Phe Lys Glu Glu Asn Ser Pro Pro Trp Ile Val 
        115                 120                 125             


Phe Asn Val Leu Ser Asp Thr Phe Phe Leu Leu Asp Leu Val Leu Asn 
    130                 135                 140                 


Phe Arg Thr Gly Ile Val Val Glu Glu Gly Ala Glu Ile Leu Leu Ala 
145                 150                 155                 160 


Pro Arg Ala Ile Arg Thr Arg Tyr Leu Arg Thr Trp Phe Leu Val Asp 
                165                 170                 175     


Leu Ile Ser Ser Ile Pro Val Asp Tyr Ile Phe Leu Val Val Glu Leu 
            180                 185                 190         


Glu Pro Arg Leu Asp Ala Glu Val Tyr Lys Thr Ala Arg Ala Leu Arg 
        195                 200                 205             


Ile Val Arg Phe Thr Lys Ile Leu Ser Leu Leu Arg Leu Leu Arg Leu 
    210                 215                 220                 


Ser Arg Leu Ile Arg Tyr Ile His Gln Trp Glu Glu Ile Phe His Met 
225                 230                 235                 240 


Thr Tyr Asp Leu Ala Ser Ala Val Val Arg Ile Phe Asn Leu Ile Gly 
                245                 250                 255     


Met Met Leu Leu Leu Cys His Trp Asp Gly Cys Leu Gln Phe Leu Val 
            260                 265                 270         


Pro Met Leu Gln Asp Phe Pro Pro Asp Cys Trp Val Ser Ile Asn His 
        275                 280                 285             


Met Val Asn His Ser Trp Gly Arg Gln Tyr Ser His Ala Leu Phe Lys 
    290                 295                 300                 


Ala Met Ser His Met Leu Cys Ile Gly Tyr Gly Gln Gln Ala Pro Val 
305                 310                 315                 320 


Gly Met Pro Asp Val Trp Leu Thr Met Leu Ser Met Ile Val Gly Ala 
                325                 330                 335     


Thr Cys Tyr Ala Met Phe Ile Gly His Ala Thr Ala Leu Ile Gln Ser 
            340                 345                 350         


Leu Asp Ser Ser Arg Arg Gln Tyr Gln Glu Lys Tyr Lys Gln Val Glu 
        355                 360                 365             


Gln Tyr Met Ser Phe His Lys Leu Pro Ala Asp Thr Arg Gln Arg Ile 
    370                 375                 380                 


His Glu Tyr Tyr Glu His Arg Tyr Gln Gly Lys Met Phe Asp Glu Glu 
385                 390                 395                 400 


Ser Ile Leu Gly Glu Leu Ser Glu Pro Leu Arg Glu Glu Ile Ile Asn 
                405                 410                 415     


Phe Thr Cys Arg Gly Leu Val Ala His Met Pro Leu Phe Ala His Ala 
            420                 425                 430         


Asp Pro Ser Phe Val Thr Ala Val Leu Thr Lys Leu Arg Phe Glu Val 
        435                 440                 445             


Phe Gln Pro Gly Asp Leu Val Val Arg Glu Gly Ser Val Gly Arg Lys 
    450                 455                 460                 


Met Tyr Phe Ile Gln His Gly Leu Leu Ser Val Leu Ala Arg Gly Ala 
465                 470                 475                 480 


Arg Asp Thr Arg Leu Thr Asp Gly Ser Tyr Phe Gly Glu Ile Cys Leu 
                485                 490                 495     


Leu Thr Arg Gly Arg Arg Thr Ala Ser Val Arg Ala Asp Thr Tyr Cys 
            500                 505                 510         


Arg Leu Tyr Ser Leu Ser Val Asp His Phe Asn Ala Val Leu Glu Glu 
        515                 520                 525             


Phe Pro Met Met Arg Arg Ala Phe Glu Thr Val Ala Met Asp Arg Leu 
    530                 535                 540                 


Leu Arg Ile Gly Lys Lys Asn Ser Ile Leu Gln Arg Lys Arg Ser Glu 
545                 550                 555                 560 


Pro Ser Pro Gly Ser Ser Gly Gly Ile Met Glu Gln His Leu Val Gln 
                565                 570                 575     


His Asp Arg Asp Met Ala Arg Gly Val Arg Gly Arg Ala Pro Ser Thr 
            580                 585                 590         


Gly Ala Gln Leu Ser Gly Lys Pro Val Leu Trp Glu Pro Leu Val His 
        595                 600                 605             


Ala Pro Leu Gln Ala Ala Ala Val Thr Ser Asn Val Ala Ile Ala Leu 
    610                 615                 620                 


Thr His Gln Arg Gly Pro Leu Pro Leu Ser Pro Asp Ser Pro Ala Thr 
625                 630                 635                 640 


Leu Leu Ala Arg Ser Ala Trp Arg Ser Ala Gly Ser Pro Ala Ser Pro 
                645                 650                 655     


Leu Val Pro Val Arg Ala Gly Pro Trp Ala Ser Thr Ser Arg Leu Pro 
            660                 665                 670         


Ala Pro Pro Ala Arg Thr Leu His Ala Ser Leu Ser Arg Ala Gly Arg 
        675                 680                 685             


Ser Gln Val Ser Leu Leu Gly Pro Pro Pro Gly Gly Gly Gly Arg Arg 
    690                 695                 700                 


Leu Gly Pro Arg Gly Arg Pro Leu Ser Ala Ser Gln Pro Ser Leu Pro 
705                 710                 715                 720 


Gln Arg Ala Thr Gly Asp Gly Ser Pro Gly Arg Lys Gly Ser Gly Ser 
                725                 730                 735     


Glu Arg Leu Pro Pro Ser Gly Leu Leu Ala Lys Pro Pro Arg Thr Ala 
            740                 745                 750         


Gln Pro Pro Arg Pro Pro Val Pro Glu Pro Ala Thr Pro Arg Gly Leu 
        755                 760                 765             


Gln Leu Ser Ala Asn Met 
    770                 


<210>  4739
<211>  1934
<212>  PRT
<213>  Homo sapiens

<400>  4739

Met Pro Gly Ala Arg Arg Arg Arg Arg Gly Ala Ala Met Glu Gly Lys 
1               5                   10                  15      


Pro Arg Ala Gly Val Ala Leu Ala Pro Gly Pro Ser Gly Arg Arg Pro 
            20                  25                  30          


Ser Ala Arg Cys Ala Arg Arg Arg Arg Pro Gly Leu Leu Leu Pro Gly 
        35                  40                  45              


Leu Trp Leu Leu Leu Leu Ala Arg Pro Ala Ser Cys Ala Pro Asp Glu 
    50                  55                  60                  


Leu Ser Pro Glu Gln His Asn Leu Ser Leu Tyr Ser Met Glu Leu Val 
65                  70                  75                  80  


Leu Lys Lys Ser Thr Gly His Ser Ala Ala Gln Val Ala Leu Thr Glu 
                85                  90                  95      


Thr Ala Pro Gly Ser Gln His Ser Ser Pro Leu His Val Thr Ala Pro 
            100                 105                 110         


Pro Ser Ala Thr Thr Phe Asp Thr Ala Phe Phe Asn Gln Gly Lys Gln 
        115                 120                 125             


Thr Lys Ser Thr Ala Asp Pro Ser Ile Phe Val Ala Thr Tyr Val Ser 
    130                 135                 140                 


Val Thr Ser Lys Glu Val Ala Val Asn Asp Asp Glu Met Asp Asn Phe 
145                 150                 155                 160 


Leu Pro Asp Thr His Trp Thr Thr Pro Arg Met Val Ser Pro Ile Gln 
                165                 170                 175     


Tyr Ile Thr Val Ser Pro Pro Gly Leu Pro Arg Glu Ala Leu Glu Pro 
            180                 185                 190         


Met Leu Thr Pro Ser Leu Pro Met Val Ser Leu Gln Asp Glu Glu Val 
        195                 200                 205             


Thr Ser Gly Trp Gln Asn Thr Thr Arg Gln Pro Ala Ala Tyr Ala Glu 
    210                 215                 220                 


Ser Ala Ser His Phe His Thr Phe Arg Ser Ala Phe Arg Thr Ser Glu 
225                 230                 235                 240 


Gly Ile Val Pro Thr Pro Gly Arg Asn Leu Val Leu Tyr Pro Thr Asp 
                245                 250                 255     


Ala Tyr Ser His Leu Ser Ser Arg Thr Leu Pro Glu Ile Val Ala Ser 
            260                 265                 270         


Leu Thr Glu Gly Val Glu Thr Thr Leu Phe Leu Ser Ser Arg Ser Leu 
        275                 280                 285             


Met Pro Gln Pro Leu Gly Asp Gly Ile Thr Ile Pro Leu Pro Ser Leu 
    290                 295                 300                 


Gly Glu Val Ser Gln Pro Pro Glu Glu Val Trp Ala Thr Ser Ala Asp 
305                 310                 315                 320 


Arg Tyr Thr Asp Val Thr Thr Val Leu Ser Gln Ser Leu Glu Glu Thr 
                325                 330                 335     


Ile Ser Pro Arg Thr Tyr Pro Thr Val Thr Ala Ser His Ala Ala Leu 
            340                 345                 350         


Ala Phe Ser Arg Thr His Ser Pro Leu Leu Ser Thr Pro Leu Ala Phe 
        355                 360                 365             


Ala Ser Ser Ala Ser Pro Thr Asp Val Ser Ser Asn Pro Phe Leu Pro 
    370                 375                 380                 


Ser Asp Ser Ser Lys Thr Ser Glu Leu His Ser Asn Ser Ala Leu Pro 
385                 390                 395                 400 


Gly Pro Val Asp Asn Thr His Ile Leu Ser Pro Val Ser Ser Phe Arg 
                405                 410                 415     


Pro Tyr Thr Trp Cys Ala Ala Cys Thr Val Pro Ser Pro Gln Gln Val 
            420                 425                 430         


Leu Ala Thr Ser Leu Met Glu Lys Asp Val Gly Ser Gly Asp Gly Ala 
        435                 440                 445             


Glu Thr Leu Cys Met Thr Val Leu Glu Glu Ser Ser Ile Ser Leu Met 
    450                 455                 460                 


Ser Ser Val Val Ala Asp Phe Ser Glu Phe Glu Glu Asp Pro Gln Val 
465                 470                 475                 480 


Phe Asn Thr Leu Phe Pro Ser Arg Pro Ile Val Pro Leu Ser Ser Arg 
                485                 490                 495     


Ser Met Glu Ile Ser Glu Thr Ser Val Gly Ile Ser Ala Glu Val Asp 
            500                 505                 510         


Met Ser Ser Val Thr Thr Thr Gln Val Pro Pro Ala His Gly Arg Leu 
        515                 520                 525             


Ser Val Pro Ala Ser Leu Asp Pro Thr Ala Gly Ser Leu Ser Val Ala 
    530                 535                 540                 


Glu Thr Gln Val Thr Pro Ser Ser Val Thr Thr Ala Phe Phe Ser Val 
545                 550                 555                 560 


Ile Thr Ser Ile Leu Leu Asp Ser Ser Phe Ser Val Ile Ala Asn Lys 
                565                 570                 575     


Asn Thr Pro Ser Leu Ala Val Arg Asp Pro Ser Val Phe Thr Pro Tyr 
            580                 585                 590         


Ser Leu Val Pro Ser Val Glu Ser Ser Leu Phe Ser Asp Gln Glu Arg 
        595                 600                 605             


Ser Ser Phe Ser Glu His Lys Pro Arg Gly Ala Leu Asp Phe Ala Ser 
    610                 615                 620                 


Ser Phe Phe Ser Thr Pro Pro Leu Glu Leu Ser Gly Ser Ile Ser Ser 
625                 630                 635                 640 


Pro Ser Glu Ala Pro Ala Ser Leu Ser Leu Met Pro Ser Asp Leu Ser 
                645                 650                 655     


Pro Phe Thr Ser Gln Ser Phe Ser Pro Leu Val Glu Thr Phe Thr Leu 
            660                 665                 670         


Phe Asp Ser Ser Asp Leu Gln Ser Ser Gln Leu Ser Leu Pro Ser Ser 
        675                 680                 685             


Thr Asn Leu Glu Phe Ser Gln Leu Gln Pro Ser Ser Glu Leu Pro Leu 
    690                 695                 700                 


Asn Thr Ile Met Leu Leu Pro Ser Arg Ser Glu Val Ser Pro Trp Ser 
705                 710                 715                 720 


Ser Phe Pro Ser Asp Ser Leu Glu Phe Val Glu Ala Ser Thr Val Ser 
                725                 730                 735     


Leu Thr Asp Ser Glu Ala His Phe Thr Ser Ala Phe Ile Glu Thr Thr 
            740                 745                 750         


Ser Tyr Leu Glu Ser Ser Leu Ile Ser His Glu Ser Ala Val Thr Ala 
        755                 760                 765             


Leu Val Pro Pro Gly Ser Glu Ser Phe Asp Ile Leu Thr Ala Gly Ile 
    770                 775                 780                 


Gln Ala Thr Ser Pro Leu Thr Thr Val His Thr Thr Pro Ile Leu Thr 
785                 790                 795                 800 


Glu Ser Ser Leu Phe Ser Thr Leu Thr Pro Pro Asp Asp Gln Ile Ser 
                805                 810                 815     


Ala Leu Asp Gly His Val Ser Val Leu Ala Ser Phe Ser Lys Ala Ile 
            820                 825                 830         


Pro Thr Gly Thr Val Leu Ile Thr Asp Ala Tyr Leu Pro Ser Gly Ser 
        835                 840                 845             


Ser Phe Val Ser Glu Ala Thr Pro Phe Pro Leu Pro Thr Glu Leu Thr 
    850                 855                 860                 


Val Val Gly Pro Ser Leu Thr Pro Thr Glu Val Pro Leu Asn Thr Ser 
865                 870                 875                 880 


Thr Glu Val Ser Thr Thr Ser Thr Gly Ala Ala Thr Gly Gly Pro Leu 
                885                 890                 895     


Asp Ser Thr Leu Met Gly Asp Ala Ala Ser Gln Ser Pro Pro Glu Ser 
            900                 905                 910         


Ser Ala Ala Pro Pro Leu Pro Ser Leu Arg Pro Val Thr Ala Phe Thr 
        915                 920                 925             


Leu Glu Ala Thr Val Asp Thr Pro Thr Leu Ala Thr Ala Lys Pro Pro 
    930                 935                 940                 


Tyr Val Cys Asp Ile Thr Val Pro Asp Ala Tyr Leu Ile Thr Thr Val 
945                 950                 955                 960 


Leu Ala Arg Arg Ala Val Gln Glu Tyr Ile Ile Thr Ala Ile Lys Glu 
                965                 970                 975     


Val Leu Arg Ile His Phe Asn Arg Ala Val Glu Leu Lys Val Tyr Glu 
            980                 985                 990         


Leu Phe Thr Asp Phe Thr Phe Leu  Val Thr Ser Gly Pro  Phe Val Tyr 
        995                 1000                 1005             


Thr Ala  Ile Ser Val Ile Asn  Val Leu Ile Asn Ser  Lys Leu Val 
    1010                 1015                 1020             


Arg Asp  Gln Thr Pro Leu Ile  Leu Ser Val Lys Pro  Ser Phe Leu 
    1025                 1030                 1035             


Val Pro  Glu Ser Arg Phe Gln  Val Gln Thr Val Leu  Gln Phe Val 
    1040                 1045                 1050             


Pro Pro  Ser Val Asp Thr Gly  Phe Cys Asn Phe Thr  Gln Arg Ile 
    1055                 1060                 1065             


Glu Lys  Gly Leu Met Thr Ala  Leu Phe Glu Val Arg  Lys His His 
    1070                 1075                 1080             


Gln Gly  Thr Tyr Asn Leu Thr  Val Gln Ile Leu Asn  Ile Thr Ile 
    1085                 1090                 1095             


Ser Ser  Ser Arg Val Thr Pro  Arg Arg Gly Pro Val  Asn Ile Ile 
    1100                 1105                 1110             


Phe Ala  Val Lys Ser Thr Gln  Gly Phe Leu Asn Gly  Ser Glu Val 
    1115                 1120                 1125             


Ser Glu  Leu Leu Arg Asn Leu  Ser Val Val Glu Phe  Ser Phe Tyr 
    1130                 1135                 1140             


Leu Gly  Tyr Pro Val Leu Gln  Ile Ala Glu Pro Phe  Gln Tyr Pro 
    1145                 1150                 1155             


Gln Leu  Asn Leu Ser Gln Leu  Leu Lys Ser Ser Trp  Val Arg Thr 
    1160                 1165                 1170             


Val Leu  Leu Gly Val Met Glu  Lys Gln Leu Gln Asn  Glu Val Phe 
    1175                 1180                 1185             


Gln Ala  Glu Met Glu Arg Lys  Leu Ala Gln Leu Leu  Ser Glu Val 
    1190                 1195                 1200             


Ser Thr  Arg Arg Arg Met Trp  Arg Arg Ala Thr Val  Ala Ala Gly 
    1205                 1210                 1215             


Asn Ser  Val Val Gln Val Val  Asn Val Ser Arg Leu  Glu Gly Asp 
    1220                 1225                 1230             


Asp Asn  Pro Val Gln Leu Ile  Tyr Phe Val Glu Asp  Gln Asp Gly 
    1235                 1240                 1245             


Glu Arg  Leu Ser Ala Val Lys  Ser Ser Asp Leu Ile  Asn Lys Met 
    1250                 1255                 1260             


Asp Leu  Gln Arg Ala Ala Ile  Ile Leu Gly Tyr Arg  Ile Gln Gly 
    1265                 1270                 1275             


Val Ile  Ala Gln Pro Val Asp  Arg Val Lys Arg Pro  Ser Pro Glu 
    1280                 1285                 1290             


Ser Gln  Ser Asn Asn Leu Trp  Val Ile Val Gly Val  Val Ile Pro 
    1295                 1300                 1305             


Val Leu  Val Val Met Val Ile  Val Val Ile Leu Tyr  Trp Lys Leu 
    1310                 1315                 1320             


Cys Arg  Thr Asp Lys Leu Asp  Phe Gln Pro Asp Thr  Val Ala Asn 
    1325                 1330                 1335             


Ile Gln  Gln Arg Gln Lys Leu  Gln Ile Pro Ser Val  Lys Gly Phe 
    1340                 1345                 1350             


Asp Phe  Ala Lys Gln His Leu  Gly Gln His Asn Lys  Asp Asp Ile 
    1355                 1360                 1365             


Leu Ile  Ile His Glu Pro Ala  Pro Leu Pro Gly Pro  Leu Lys Asp 
    1370                 1375                 1380             


His Thr  Thr Pro Ser Glu Asn  Gly Asp Val Pro Ser  Pro Lys Ser 
    1385                 1390                 1395             


Lys Ile  Pro Ser Lys Asn Val  Arg His Arg Gly Arg  Val Ser Pro 
    1400                 1405                 1410             


Ser Asp  Ala Asp Ser Thr Val  Ser Glu Glu Ser Ser  Glu Arg Asp 
    1415                 1420                 1425             


Ala Gly  Asp Lys Thr Pro Gly  Ala Val Asn Asp Gly  Arg Ser His 
    1430                 1435                 1440             


Arg Ala  Pro Gln Ser Gly Pro  Pro Leu Pro Ser Ser  Gly Asn Glu 
    1445                 1450                 1455             


Gln His  Ser Ser Ala Ser Ile  Phe Glu His Val Asp  Arg Ile Ser 
    1460                 1465                 1470             


Arg Pro  Pro Glu Ala Ser Arg  Arg Val Pro Ser Lys  Ile Gln Leu 
    1475                 1480                 1485             


Ile Ala  Met Gln Pro Ile Pro  Ala Pro Pro Val Gln  Arg Pro Ser 
    1490                 1495                 1500             


Pro Ala  Asp Arg Val Ala Glu  Ser Asn Lys Ile Asn  Lys Glu Ile 
    1505                 1510                 1515             


Gln Thr  Ala Leu Arg His Lys  Ser Glu Ile Glu His  His Arg Asn 
    1520                 1525                 1530             


Lys Ile  Arg Leu Arg Ala Lys  Arg Arg Gly His Tyr  Glu Phe Pro 
    1535                 1540                 1545             


Val Val  Asp Asp Leu Ser Ser  Gly Asp Thr Lys Glu  Arg His Arg 
    1550                 1555                 1560             


Val Tyr  Arg Arg Ala Gln Met  Gln Ile Asp Lys Ile  Leu Asp Pro 
    1565                 1570                 1575             


Thr Ala  Ser Val Pro Ser Val  Phe Ile Glu Pro Arg  Lys Ser Ser 
    1580                 1585                 1590             


Arg Ile  Lys Arg Ser Pro Lys  Pro Arg Arg Lys His  Gln Val Asn 
    1595                 1600                 1605             


Gly Cys  Pro Ala Asp Ala Glu  Lys Asp Arg Leu Ile  Thr Thr Asp 
    1610                 1615                 1620             


Ser Asp  Gly Thr Tyr Arg Arg  Pro Pro Gly Val His  Asn Ser Ala 
    1625                 1630                 1635             


Tyr Ile  Gly Cys Pro Ser Asp  Pro Asp Leu Pro Ala  Asp Val Gln 
    1640                 1645                 1650             


Thr Pro  Ser Ser Val Glu Leu  Gly Arg Tyr Pro Ala  Leu Pro Phe 
    1655                 1660                 1665             


Pro Ala  Ser Gln Tyr Ile Pro  Pro Gln Pro Ser Ile  Glu Glu Ala 
    1670                 1675                 1680             


Arg Gln  Thr Met His Ser Leu  Leu Asp Asp Ala Phe  Ala Leu Val 
    1685                 1690                 1695             


Ala Pro  Ser Ser Gln Pro Ala  Ser Thr Ala Gly Val  Gly Pro Gly 
    1700                 1705                 1710             


Val Pro  Pro Gly Leu Pro Ala  Asn Ser Thr Pro Ser  Gln Glu Glu 
    1715                 1720                 1725             


Arg Arg  Ala Thr Gln Trp Gly  Ser Phe Tyr Ser Pro  Ala Gln Thr 
    1730                 1735                 1740             


Ala Asn  Asn Pro Cys Ser Arg  Tyr Glu Asp Tyr Gly  Met Thr Pro 
    1745                 1750                 1755             


Pro Thr  Gly Pro Leu Pro Arg  Pro Gly Phe Gly Pro  Gly Leu Leu 
    1760                 1765                 1770             


Gln Ser  Thr Glu Leu Val Pro  Pro Asp Pro Gln Gln  Pro Gln Ala 
    1775                 1780                 1785             


Ser Ala  Glu Ala Pro Phe Ala  Ala Arg Gly Ile Tyr  Ser Glu Glu 
    1790                 1795                 1800             


Met Pro  Ser Val Ala Arg Pro  Arg Pro Val Gly Gly  Thr Thr Gly 
    1805                 1810                 1815             


Ser Gln  Ile Gln His Leu Thr  Gln Val Gly Ile Ala  Ser Arg Ile 
    1820                 1825                 1830             


Gly Ala  Gln Pro Val Glu Ile  Pro Pro Ser Arg Gly  Ser Gln Tyr 
    1835                 1840                 1845             


Gly Gly  Pro Gly Trp Pro Ser  Tyr Gly Glu Asp Glu  Ala Gly Arg 
    1850                 1855                 1860             


Arg Glu  Ala Val Pro Arg Thr  Ser Gly Arg Glu Pro  Ser Ala Pro 
    1865                 1870                 1875             


Ser Gly  Asn Leu Pro His Arg  Gly Leu Gln Gly Pro  Gly Leu Gly 
    1880                 1885                 1890             


Tyr Pro  Thr Ser Ser Thr Glu  Asp Leu Gln Pro Gly  His Ser Ser 
    1895                 1900                 1905             


Ala Ser  Leu Ile Lys Ala Ile  Arg Glu Glu Leu Leu  Arg Leu Ser 
    1910                 1915                 1920             


Gln Lys  Gln Ser Thr Val Gln  Asn Phe His Ser 
    1925                 1930                 


<210>  4740
<211>  1894
<212>  PRT
<213>  Homo sapiens

<400>  4740

Met Lys Ala Met Pro Trp Asn Trp Thr Cys Leu Leu Ser His Leu Leu 
1               5                   10                  15      


Met Val Gly Met Gly Ser Ser Thr Leu Leu Thr Arg Gln Pro Ala Pro 
            20                  25                  30          


Leu Ser Gln Lys Gln Arg Ser Phe Val Thr Phe Arg Gly Glu Pro Ala 
        35                  40                  45              


Glu Gly Phe Asn His Leu Val Val Asp Glu Arg Thr Gly His Ile Tyr 
    50                  55                  60                  


Leu Gly Ala Val Asn Arg Ile Tyr Lys Leu Ser Ser Asp Leu Lys Val 
65                  70                  75                  80  


Leu Val Thr His Glu Thr Gly Pro Asp Glu Asp Asn Pro Lys Cys Tyr 
                85                  90                  95      


Pro Pro Arg Ile Val Gln Thr Cys Asn Glu Pro Leu Thr Thr Thr Asn 
            100                 105                 110         


Asn Val Asn Lys Met Leu Leu Ile Asp Tyr Lys Glu Asn Arg Leu Ile 
        115                 120                 125             


Ala Cys Gly Ser Leu Tyr Gln Gly Ile Cys Lys Leu Leu Arg Leu Glu 
    130                 135                 140                 


Asp Leu Phe Lys Leu Gly Glu Pro Tyr His Lys Lys Glu His Tyr Leu 
145                 150                 155                 160 


Ser Gly Val Asn Glu Ser Gly Ser Val Phe Gly Val Ile Val Ser Tyr 
                165                 170                 175     


Ser Asn Leu Asp Asp Lys Leu Phe Ile Ala Thr Ala Val Asp Gly Lys 
            180                 185                 190         


Pro Glu Tyr Phe Pro Thr Ile Ser Ser Arg Lys Leu Thr Lys Asn Ser 
        195                 200                 205             


Glu Ala Asp Gly Met Phe Ala Tyr Val Phe His Asp Glu Phe Val Ala 
    210                 215                 220                 


Ser Met Ile Lys Ile Pro Ser Asp Thr Phe Thr Ile Ile Pro Asp Phe 
225                 230                 235                 240 


Asp Ile Tyr Tyr Val Tyr Gly Phe Ser Ser Gly Asn Phe Val Tyr Phe 
                245                 250                 255     


Leu Thr Leu Gln Pro Glu Met Val Ser Pro Pro Gly Ser Thr Thr Lys 
            260                 265                 270         


Glu Gln Val Tyr Thr Ser Lys Leu Val Arg Leu Cys Lys Glu Asp Thr 
        275                 280                 285             


Ala Phe Asn Ser Tyr Val Glu Val Pro Ile Gly Cys Glu Arg Ser Gly 
    290                 295                 300                 


Val Glu Tyr Arg Leu Leu Gln Ala Ala Tyr Leu Ser Lys Ala Gly Ala 
305                 310                 315                 320 


Val Leu Gly Arg Thr Leu Gly Val His Pro Asp Asp Asp Leu Leu Phe 
                325                 330                 335     


Thr Val Phe Ser Lys Gly Gln Lys Arg Lys Met Lys Ser Leu Asp Glu 
            340                 345                 350         


Ser Ala Leu Cys Ile Phe Ile Leu Lys Gln Ile Asn Asp Arg Ile Lys 
        355                 360                 365             


Glu Arg Leu Gln Ser Cys Tyr Arg Gly Glu Gly Thr Leu Asp Leu Ala 
    370                 375                 380                 


Trp Leu Lys Val Lys Asp Ile Pro Cys Ser Ser Ala Leu Leu Thr Ile 
385                 390                 395                 400 


Asp Asp Asn Phe Cys Gly Leu Asp Met Asn Ala Pro Leu Gly Val Ser 
                405                 410                 415     


Asp Met Val Arg Gly Ile Pro Val Phe Thr Glu Asp Arg Asp Arg Met 
            420                 425                 430         


Thr Ser Val Ile Ala Tyr Val Tyr Lys Asn His Ser Leu Ala Phe Val 
        435                 440                 445             


Gly Thr Lys Ser Gly Lys Leu Lys Lys Ile Arg Val Asp Gly Pro Arg 
    450                 455                 460                 


Gly Asn Ala Leu Gln Tyr Glu Thr Val Gln Val Val Asp Pro Gly Pro 
465                 470                 475                 480 


Val Leu Arg Asp Met Ala Phe Ser Lys Asp His Glu Gln Leu Tyr Ile 
                485                 490                 495     


Met Ser Glu Arg Gln Leu Thr Arg Val Pro Val Glu Ser Cys Gly Gln 
            500                 505                 510         


Tyr Gln Ser Cys Gly Glu Cys Leu Gly Ser Gly Asp Pro His Cys Gly 
        515                 520                 525             


Trp Cys Val Leu His Asn Thr Cys Thr Arg Lys Glu Arg Cys Glu Arg 
    530                 535                 540                 


Ser Lys Glu Pro Arg Arg Phe Ala Ser Glu Met Lys Gln Cys Val Arg 
545                 550                 555                 560 


Leu Thr Val His Pro Asn Asn Ile Ser Val Ser Gln Tyr Asn Val Leu 
                565                 570                 575     


Leu Val Leu Glu Thr Tyr Asn Val Pro Glu Leu Ser Ala Gly Val Asn 
            580                 585                 590         


Cys Thr Phe Glu Asp Leu Ser Glu Met Asp Gly Leu Val Val Gly Asn 
        595                 600                 605             


Gln Ile Gln Cys Tyr Ser Pro Ala Ala Lys Glu Val Pro Arg Ile Ile 
    610                 615                 620                 


Thr Glu Asn Gly Asp His His Val Val Gln Leu Gln Leu Lys Ser Lys 
625                 630                 635                 640 


Glu Thr Gly Met Thr Phe Ala Ser Thr Ser Phe Val Phe Tyr Asn Cys 
                645                 650                 655     


Ser Val His Asn Ser Cys Leu Ser Cys Val Glu Ser Pro Tyr Arg Cys 
            660                 665                 670         


His Trp Cys Lys Tyr Arg His Val Cys Thr His Asp Pro Lys Thr Cys 
        675                 680                 685             


Ser Phe Gln Glu Gly Arg Val Lys Leu Pro Glu Asp Cys Pro Gln Leu 
    690                 695                 700                 


Leu Arg Val Asp Lys Ile Leu Val Pro Val Glu Val Ile Lys Pro Ile 
705                 710                 715                 720 


Thr Leu Lys Ala Lys Asn Leu Pro Gln Pro Gln Ser Gly Gln Arg Gly 
                725                 730                 735     


Tyr Glu Cys Ile Leu Asn Ile Gln Gly Ser Glu Gln Arg Val Pro Ala 
            740                 745                 750         


Leu Arg Phe Asn Ser Ser Ser Val Gln Cys Gln Asn Thr Ser Tyr Ser 
        755                 760                 765             


Tyr Glu Gly Met Glu Ile Asn Asn Leu Pro Val Glu Leu Thr Val Val 
    770                 775                 780                 


Trp Asn Gly His Phe Asn Ile Asp Asn Pro Ala Gln Asn Lys Val His 
785                 790                 795                 800 


Leu Tyr Lys Cys Gly Ala Met Arg Glu Ser Cys Gly Leu Cys Leu Lys 
                805                 810                 815     


Ala Asp Pro Asp Phe Ala Cys Gly Trp Cys Gln Gly Pro Gly Gln Cys 
            820                 825                 830         


Thr Leu Arg Gln His Cys Pro Ala Gln Glu Ser Gln Trp Leu Glu Leu 
        835                 840                 845             


Ser Gly Ala Lys Ser Lys Cys Thr Asn Pro Arg Ile Thr Glu Ile Ile 
    850                 855                 860                 


Pro Val Thr Gly Pro Arg Glu Gly Gly Thr Lys Val Thr Ile Arg Gly 
865                 870                 875                 880 


Glu Asn Leu Gly Leu Glu Phe Arg Asp Ile Ala Ser His Val Lys Val 
                885                 890                 895     


Ala Gly Val Glu Cys Ser Pro Leu Val Asp Gly Tyr Ile Pro Ala Glu 
            900                 905                 910         


Gln Ile Val Cys Glu Met Gly Glu Ala Lys Pro Ser Gln His Ala Gly 
        915                 920                 925             


Phe Val Glu Ile Cys Val Ala Val Cys Arg Pro Glu Phe Met Ala Arg 
    930                 935                 940                 


Ser Ser Gln Leu Tyr Tyr Phe Met Thr Leu Thr Leu Ser Asp Leu Lys 
945                 950                 955                 960 


Pro Ser Arg Gly Pro Met Ser Gly Gly Thr Gln Val Thr Ile Thr Gly 
                965                 970                 975     


Thr Asn Leu Asn Ala Gly Ser Asn Val Val Val Met Phe Gly Lys Gln 
            980                 985                 990         


Pro Cys Leu Phe His Arg Arg Ser  Pro Ser Tyr Ile Val  Cys Asn Thr 
        995                 1000                 1005             


Thr Ser  Ser Asp Glu Val Leu  Glu Met Lys Val Ser  Val Gln Val 
    1010                 1015                 1020             


Asp Arg  Ala Lys Ile His Gln  Asp Leu Val Phe Gln  Tyr Val Glu 
    1025                 1030                 1035             


Asp Pro  Thr Ile Val Arg Ile  Glu Pro Glu Trp Ser  Ile Val Ser 
    1040                 1045                 1050             


Gly Asn  Thr Pro Ile Ala Val  Trp Gly Thr His Leu  Asp Leu Ile 
    1055                 1060                 1065             


Gln Asn  Pro Gln Ile Arg Ala  Lys His Gly Gly Lys  Glu His Ile 
    1070                 1075                 1080             


Asn Ile  Cys Glu Val Leu Asn  Ala Thr Glu Met Thr  Cys Gln Ala 
    1085                 1090                 1095             


Pro Ala  Leu Ala Leu Gly Pro  Asp His Gln Ser Asp  Leu Thr Glu 
    1100                 1105                 1110             


Arg Pro  Glu Glu Phe Gly Phe  Ile Leu Asp Asn Val  Gln Ser Leu 
    1115                 1120                 1125             


Leu Ile  Leu Asn Lys Thr Asn  Phe Thr Tyr Tyr Pro  Asn Pro Val 
    1130                 1135                 1140             


Phe Glu  Ala Phe Gly Pro Ser  Gly Ile Leu Glu Leu  Lys Pro Gly 
    1145                 1150                 1155             


Thr Pro  Ile Ile Leu Lys Gly  Lys Asn Leu Ile Pro  Pro Val Ala 
    1160                 1165                 1170             


Gly Gly  Asn Val Lys Leu Asn  Tyr Thr Val Leu Val  Gly Glu Lys 
    1175                 1180                 1185             


Pro Cys  Thr Val Thr Val Ser  Asp Val Gln Leu Leu  Cys Glu Ser 
    1190                 1195                 1200             


Pro Asn  Leu Ile Gly Arg His  Lys Val Met Ala Arg  Val Gly Gly 
    1205                 1210                 1215             


Met Glu  Tyr Ser Pro Gly Met  Val Tyr Ile Ala Pro  Asp Ser Pro 
    1220                 1225                 1230             


Leu Ser  Leu Pro Ala Ile Val  Ser Ile Ala Val Ala  Gly Gly Leu 
    1235                 1240                 1245             


Leu Ile  Ile Phe Ile Val Ala  Val Leu Ile Ala Tyr  Lys Arg Lys 
    1250                 1255                 1260             


Ser Arg  Glu Ser Asp Leu Thr  Leu Lys Arg Leu Gln  Met Gln Met 
    1265                 1270                 1275             


Asp Asn  Leu Glu Ser Arg Val  Ala Leu Glu Cys Lys  Glu Ala Phe 
    1280                 1285                 1290             


Ala Glu  Leu Gln Thr Asp Ile  His Glu Leu Thr Ser  Asp Leu Asp 
    1295                 1300                 1305             


Gly Ala  Gly Ile Pro Phe Leu  Asp Tyr Arg Thr Tyr  Thr Met Arg 
    1310                 1315                 1320             


Val Leu  Phe Pro Gly Ile Glu  Asp His Pro Val Leu  Arg Asp Leu 
    1325                 1330                 1335             


Glu Val  Pro Gly Tyr Arg Gln  Glu Arg Val Glu Lys  Gly Leu Lys 
    1340                 1345                 1350             


Leu Phe  Ala Gln Leu Ile Asn  Asn Lys Val Phe Leu  Leu Ser Phe 
    1355                 1360                 1365             


Ile Arg  Thr Leu Glu Ser Gln  Arg Ser Phe Ser Met  Arg Asp Arg 
    1370                 1375                 1380             


Gly Asn  Val Ala Ser Leu Ile  Met Thr Val Leu Gln  Ser Lys Leu 
    1385                 1390                 1395             


Glu Tyr  Ala Thr Asp Val Leu  Lys Gln Leu Leu Ala  Asp Leu Ile 
    1400                 1405                 1410             


Asp Lys  Asn Leu Glu Ser Lys  Asn His Pro Lys Leu  Leu Leu Arg 
    1415                 1420                 1425             


Arg Thr  Glu Ser Val Ala Glu  Lys Met Leu Thr Asn  Trp Phe Thr 
    1430                 1435                 1440             


Phe Leu  Leu Tyr Lys Phe Leu  Lys Glu Cys Ala Gly  Glu Pro Leu 
    1445                 1450                 1455             


Phe Ser  Leu Phe Cys Ala Ile  Lys Gln Gln Met Glu  Lys Gly Pro 
    1460                 1465                 1470             


Ile Asp  Ala Ile Thr Gly Glu  Ala Arg Tyr Ser Leu  Ser Glu Asp 
    1475                 1480                 1485             


Lys Leu  Ile Arg Gln Gln Ile  Asp Tyr Lys Thr Leu  Val Leu Ser 
    1490                 1495                 1500             


Cys Val  Ser Pro Asp Asn Ala  Asn Ser Pro Glu Val  Pro Val Lys 
    1505                 1510                 1515             


Ile Leu  Asn Cys Asp Thr Ile  Thr Gln Val Lys Glu  Lys Ile Leu 
    1520                 1525                 1530             


Asp Ala  Ile Phe Lys Asn Val  Pro Cys Ser His Arg  Pro Lys Ala 
    1535                 1540                 1545             


Ala Asp  Met Asp Leu Glu Trp  Arg Gln Gly Ser Gly  Ala Arg Met 
    1550                 1555                 1560             


Ile Leu  Gln Asp Glu Asp Ile  Thr Thr Lys Ile Glu  Asn Asp Trp 
    1565                 1570                 1575             


Lys Arg  Leu Asn Thr Leu Ala  His Tyr Gln Val Pro  Asp Gly Ser 
    1580                 1585                 1590             


Val Val  Ala Leu Val Ser Lys  Gln Val Thr Ala Tyr  Asn Ala Val 
    1595                 1600                 1605             


Asn Asn  Ser Thr Val Ser Arg  Thr Ser Ala Ser Lys  Tyr Glu Asn 
    1610                 1615                 1620             


Met Ile  Arg Tyr Thr Gly Ser  Pro Asp Ser Leu Arg  Ser Arg Thr 
    1625                 1630                 1635             


Pro Met  Ile Thr Pro Asp Leu  Glu Ser Gly Val Lys  Met Trp His 
    1640                 1645                 1650             


Leu Val  Lys Asn His Glu His  Gly Asp Gln Lys Glu  Gly Asp Arg 
    1655                 1660                 1665             


Gly Ser  Lys Met Val Ser Glu  Ile Tyr Leu Thr Arg  Leu Leu Ala 
    1670                 1675                 1680             


Thr Lys  Gly Thr Leu Gln Lys  Phe Val Asp Asp Leu  Phe Glu Thr 
    1685                 1690                 1695             


Ile Phe  Ser Thr Ala His Arg  Gly Ser Ala Leu Pro  Leu Ala Ile 
    1700                 1705                 1710             


Lys Tyr  Met Phe Asp Phe Leu  Asp Glu Gln Ala Asp  Lys His Gly 
    1715                 1720                 1725             


Ile His  Asp Pro His Val Arg  His Thr Trp Lys Ser  Asn Cys Leu 
    1730                 1735                 1740             


Pro Leu  Arg Phe Trp Val Asn  Met Ile Lys Asn Pro  Gln Phe Val 
    1745                 1750                 1755             


Phe Asp  Ile His Lys Asn Ser  Ile Thr Asp Ala Cys  Leu Ser Val 
    1760                 1765                 1770             


Val Ala  Gln Thr Phe Met Asp  Ser Cys Ser Thr Ser  Glu His Arg 
    1775                 1780                 1785             


Leu Gly  Lys Asp Ser Pro Ser  Asn Lys Leu Leu Tyr  Ala Lys Asp 
    1790                 1795                 1800             


Ile Pro  Ser Tyr Lys Asn Trp  Val Glu Arg Tyr Tyr  Ser Asp Ile 
    1805                 1810                 1815             


Gly Lys  Met Pro Ala Ile Ser  Asp Gln Asp Met Asn  Ala Tyr Leu 
    1820                 1825                 1830             


Ala Glu  Gln Ser Arg Met His  Met Asn Glu Phe Asn  Thr Met Ser 
    1835                 1840                 1845             


Ala Leu  Ser Glu Ile Phe Ser  Tyr Val Gly Lys Tyr  Ser Glu Glu 
    1850                 1855                 1860             


Ile Leu  Gly Pro Leu Asp His  Asp Asp Gln Cys Gly  Lys Gln Lys 
    1865                 1870                 1875             


Leu Ala  Tyr Lys Leu Glu Gln  Val Ile Thr Leu Met  Ser Leu Asp 
    1880                 1885                 1890             


Ser 
    


<210>  4741
<211>  1223
<212>  PRT
<213>  Homo sapiens

<400>  4741

Met Arg Arg Leu Ala Ala Glu Glu Leu Gly Val Val Thr Met Gln Arg 
1               5                   10                  15      


Ile Phe Asn Ser Phe Val Tyr Thr Glu Lys Ile Ser Asn Gly Glu Ser 
            20                  25                  30          


Glu Val Gln Gln Leu Ala Lys Lys Ile Arg Glu Lys Phe Asn Arg Tyr 
        35                  40                  45              


Leu Asp Val Val Asn Arg Asn Lys Gln Val Val Glu Ala Ser Tyr Thr 
    50                  55                  60                  


Ala His Leu Thr Ser Pro Leu Thr Ala Ile Gln Asp Cys Cys Thr Ile 
65                  70                  75                  80  


Pro Pro Ser Met Met Glu Phe Asp Gly Asn Phe Asn Thr Asn Val Ser 
                85                  90                  95      


Arg Thr Ile Ser Cys Asp Arg Leu Ser Thr Thr Val Asn Ser Arg Ala 
            100                 105                 110         


Phe Asn Pro Gly Arg Asp Leu Asn Ser Val Leu Ala Asp Asn Leu Lys 
        115                 120                 125             


Ser Asn Pro Gly Ile Lys Trp Gln Tyr Phe Ser Ser Glu Glu Gly Ile 
    130                 135                 140                 


Phe Thr Val Phe Pro Ala His Lys Phe Arg Cys Lys Gly Ser Tyr Glu 
145                 150                 155                 160 


His Arg Ser Arg Pro Ile Tyr Val Ser Thr Val Arg Pro Gln Ser Lys 
                165                 170                 175     


His Ile Val Val Ile Leu Asp His Gly Ala Ser Val Thr Asp Thr Gln 
            180                 185                 190         


Leu Gln Ile Ala Lys Asp Ala Ala Gln Val Ile Leu Ser Ala Ile Asp 
        195                 200                 205             


Glu His Asp Lys Ile Ser Val Leu Thr Val Ala Asp Thr Val Arg Thr 
    210                 215                 220                 


Cys Ser Leu Asp Gln Cys Tyr Lys Thr Phe Leu Ser Pro Ala Thr Ser 
225                 230                 235                 240 


Glu Thr Lys Arg Lys Met Ser Thr Phe Val Ser Ser Val Lys Ser Ser 
                245                 250                 255     


Asp Ser Pro Thr Gln His Ala Val Gly Phe Gln Lys Ala Phe Gln Leu 
            260                 265                 270         


Ile Arg Ser Thr Asn Asn Asn Thr Lys Phe Gln Ala Asn Thr Asp Met 
        275                 280                 285             


Val Ile Ile Tyr Leu Ser Ala Gly Ile Thr Ser Lys Asp Ser Ser Glu 
    290                 295                 300                 


Glu Asp Lys Lys Ala Thr Leu Gln Val Ile Asn Glu Glu Asn Ser Phe 
305                 310                 315                 320 


Leu Asn Asn Ser Val Met Ile Leu Thr Tyr Ala Leu Met Asn Asp Gly 
                325                 330                 335     


Val Thr Gly Leu Lys Glu Leu Ala Phe Leu Arg Asp Leu Ala Glu Gln 
            340                 345                 350         


Asn Ser Gly Lys Tyr Gly Val Pro Asp Arg Met Ala Leu Pro Val Ile 
        355                 360                 365             


Lys Gly Ser Met Met Val Leu Asn Gln Leu Ser Asn Leu Glu Thr Thr 
    370                 375                 380                 


Val Gly Arg Phe Tyr Thr Asn Leu Pro Asn Arg Met Ile Asp Glu Ala 
385                 390                 395                 400 


Val Phe Ser Leu Pro Phe Ser Asp Glu Met Gly Asp Gly Leu Ile Met 
                405                 410                 415     


Thr Val Ser Lys Pro Cys Tyr Phe Gly Asn Leu Leu Leu Gly Ile Val 
            420                 425                 430         


Gly Val Asp Val Asn Leu Ala Tyr Ile Leu Glu Asp Val Thr Tyr Tyr 
        435                 440                 445             


Gln Asp Ser Leu Ala Ser Tyr Thr Phe Leu Ile Asp Asp Lys Gly Tyr 
    450                 455                 460                 


Thr Leu Met His Pro Ser Leu Thr Arg Pro Tyr Leu Leu Ser Glu Pro 
465                 470                 475                 480 


Pro Leu His Thr Asp Ile Ile His Tyr Glu Asn Ile Pro Lys Phe Glu 
                485                 490                 495     


Leu Val Arg Gln Asn Ile Leu Ser Leu Pro Leu Gly Ser Gln Ile Ile 
            500                 505                 510         


Ala Val Pro Val Asn Ser Ser Leu Ser Trp His Ile Asn Lys Leu Arg 
        515                 520                 525             


Glu Thr Gly Lys Glu Ala Tyr Asn Val Ser Tyr Ala Trp Lys Met Val 
    530                 535                 540                 


Gln Asp Thr Ser Phe Ile Leu Cys Ile Val Val Ile Gln Pro Glu Ile 
545                 550                 555                 560 


Pro Val Lys Gln Leu Lys Asn Leu Asn Thr Val Pro Ser Ser Lys Leu 
                565                 570                 575     


Leu Tyr His Arg Leu Asp Leu Leu Gly Gln Pro Ser Ala Cys Leu His 
            580                 585                 590         


Phe Lys Gln Leu Ala Thr Leu Glu Ser Pro Thr Ile Met Leu Ser Ala 
        595                 600                 605             


Gly Ser Phe Ser Ser Pro Tyr Glu His Leu Ser Gln Pro Glu Thr Lys 
    610                 615                 620                 


Arg Met Val Glu His Tyr Thr Ala Tyr Leu Ser Asp Asn Thr Arg Leu 
625                 630                 635                 640 


Ile Ala Asn Pro Gly Leu Lys Phe Ser Val Arg Asn Glu Val Met Ala 
                645                 650                 655     


Thr Ser His Val Thr Asp Glu Trp Met Thr Gln Met Glu Met Ser Ser 
            660                 665                 670         


Leu Asn Thr Tyr Ile Val Arg Arg Tyr Ile Ala Thr Pro Asn Gly Val 
        675                 680                 685             


Leu Arg Ile Tyr Pro Gly Ser Leu Met Asp Lys Ala Phe Asp Pro Thr 
    690                 695                 700                 


Arg Arg Gln Trp Tyr Leu His Ala Val Ala Asn Pro Gly Leu Ile Ser 
705                 710                 715                 720 


Leu Thr Gly Pro Tyr Leu Asp Val Gly Gly Ala Gly Tyr Val Val Thr 
                725                 730                 735     


Ile Ser His Thr Ile His Ser Ser Ser Thr Gln Leu Ser Ser Gly His 
            740                 745                 750         


Thr Val Ala Val Met Gly Ile Asp Phe Thr Leu Arg Tyr Phe Tyr Lys 
        755                 760                 765             


Val Leu Met Asp Leu Leu Pro Val Cys Asn Gln Asp Gly Gly Asn Lys 
    770                 775                 780                 


Ile Arg Cys Phe Ile Met Glu Asp Arg Gly Tyr Leu Val Ala His Pro 
785                 790                 795                 800 


Thr Leu Ile Asp Pro Lys Gly His Ala Pro Val Glu Gln Gln His Ile 
                805                 810                 815     


Thr His Lys Glu Pro Leu Val Ala Asn Asp Ile Leu Asn His Pro Asn 
            820                 825                 830         


Phe Val Lys Lys Asn Leu Cys Asn Ser Phe Ser Asp Arg Thr Val Gln 
        835                 840                 845             


Arg Phe Tyr Lys Phe Asn Thr Ser Leu Ala Gly Asp Leu Thr Asn Leu 
    850                 855                 860                 


Val His Gly Ser His Cys Ser Lys Tyr Arg Leu Ala Arg Ile Pro Gly 
865                 870                 875                 880 


Thr Asn Ala Phe Val Gly Ile Val Asn Glu Thr Cys Asp Ser Leu Ala 
                885                 890                 895     


Phe Cys Ala Cys Ser Met Val Asp Arg Leu Cys Leu Asn Cys His Arg 
            900                 905                 910         


Met Glu Gln Asn Glu Cys Glu Cys Pro Cys Glu Cys Pro Leu Glu Val 
        915                 920                 925             


Asn Glu Cys Thr Gly Asn Leu Thr Asn Ala Glu Asn Arg Asn Pro Ser 
    930                 935                 940                 


Cys Glu Val His Gln Glu Pro Val Thr Tyr Thr Ala Ile Asp Pro Gly 
945                 950                 955                 960 


Leu Gln Asp Ala Leu His Gln Cys Val Asn Ser Arg Cys Ser Gln Arg 
                965                 970                 975     


Leu Glu Ser Gly Asp Cys Phe Gly Val Leu Asp Cys Glu Trp Cys Met 
            980                 985                 990         


Val Asp Ser Asp Gly Lys Thr His  Leu Asp Lys Pro Tyr  Cys Ala Pro 
        995                 1000                 1005             


Gln Lys  Glu Cys Phe Gly Gly  Ile Val Gly Ala Lys  Ser Pro Tyr 
    1010                 1015                 1020             


Val Asp  Asp Met Gly Ala Ile  Gly Asp Glu Val Ile  Thr Leu Asn 
    1025                 1030                 1035             


Met Ile  Lys Ser Ala Pro Val  Gly Pro Val Ala Gly  Gly Ile Met 
    1040                 1045                 1050             


Gly Cys  Ile Met Val Leu Val  Leu Ala Val Tyr Ala  Tyr Arg His 
    1055                 1060                 1065             


Gln Ile  His Arg Arg Ser His  Gln His Met Ser Pro  Leu Ala Ala 
    1070                 1075                 1080             


Gln Glu  Met Ser Val Arg Met  Ser Asn Leu Glu Asn  Asp Arg Asp 
    1085                 1090                 1095             


Glu Arg  Asp Asp Asp Ser His  Glu Asp Arg Gly Ile  Ile Ser Asn 
    1100                 1105                 1110             


Thr Arg  Phe Ile Ala Ala Val  Ile Glu Arg His Ala  His Ser Pro 
    1115                 1120                 1125             


Glu Arg  Arg Arg Arg Tyr Trp  Gly Arg Ser Gly Thr  Glu Ser Asp 
    1130                 1135                 1140             


His Gly  Tyr Ser Thr Met Ser  Pro Gln Glu Asp Ser  Glu Asn Pro 
    1145                 1150                 1155             


Pro Cys  Asn Asn Asp Pro Leu  Ser Ala Gly Val Asp  Val Gly Asn 
    1160                 1165                 1170             


His Asp  Glu Asp Leu Asp Leu  Asp Thr Pro Pro Gln  Thr Ala Ala 
    1175                 1180                 1185             


Leu Leu  Ser His Lys Phe His  His Tyr Arg Ser His  His Pro Thr 
    1190                 1195                 1200             


Leu His  His Ser His His Leu  Gln Ala Ala Val Thr  Val His Thr 
    1205                 1210                 1215             


Val Asp  Ala Glu Cys 
    1220             


<210>  4742
<211>  640
<212>  PRT
<213>  Homo sapiens

<400>  4742

Met Leu Asn Lys Met Thr Leu His Pro Gln Gln Ile Met Ile Gly Pro 
1               5                   10                  15      


Arg Phe Asn Arg Ala Leu Phe Asp Pro Leu Leu Val Val Leu Leu Ala 
            20                  25                  30          


Leu Gln Leu Leu Val Val Ala Gly Leu Val Arg Ala Gln Thr Cys Pro 
        35                  40                  45              


Ser Val Cys Ser Cys Ser Asn Gln Phe Ser Lys Val Ile Cys Val Arg 
    50                  55                  60                  


Lys Asn Leu Arg Glu Val Pro Asp Gly Ile Ser Thr Asn Thr Arg Leu 
65                  70                  75                  80  


Leu Asn Leu His Glu Asn Gln Ile Gln Ile Ile Lys Val Asn Ser Phe 
                85                  90                  95      


Lys His Leu Arg His Leu Glu Ile Leu Gln Leu Ser Arg Asn His Ile 
            100                 105                 110         


Arg Thr Ile Glu Ile Gly Ala Phe Asn Gly Leu Ala Asn Leu Asn Thr 
        115                 120                 125             


Leu Glu Leu Phe Asp Asn Arg Leu Thr Thr Ile Pro Asn Gly Ala Phe 
    130                 135                 140                 


Val Tyr Leu Ser Lys Leu Lys Glu Leu Trp Leu Arg Asn Asn Pro Ile 
145                 150                 155                 160 


Glu Ser Ile Pro Ser Tyr Ala Phe Asn Arg Ile Pro Ser Leu Arg Arg 
                165                 170                 175     


Leu Asp Leu Gly Glu Leu Lys Arg Leu Ser Tyr Ile Ser Glu Gly Ala 
            180                 185                 190         


Phe Glu Gly Leu Ser Asn Leu Arg Tyr Leu Asn Leu Ala Met Cys Asn 
        195                 200                 205             


Leu Arg Glu Ile Pro Asn Leu Thr Pro Leu Ile Lys Leu Asp Glu Leu 
    210                 215                 220                 


Asp Leu Ser Gly Asn His Leu Ser Ala Ile Arg Pro Gly Ser Phe Gln 
225                 230                 235                 240 


Gly Leu Met His Leu Gln Lys Leu Trp Met Ile Gln Ser Gln Ile Gln 
                245                 250                 255     


Val Ile Glu Arg Asn Ala Phe Asp Asn Leu Gln Ser Leu Val Glu Ile 
            260                 265                 270         


Asn Leu Ala His Asn Asn Leu Thr Leu Leu Pro His Asp Leu Phe Thr 
        275                 280                 285             


Pro Leu His His Leu Glu Arg Ile His Leu His His Asn Pro Trp Asn 
    290                 295                 300                 


Cys Asn Cys Asp Ile Leu Trp Leu Ser Trp Trp Ile Lys Asp Met Ala 
305                 310                 315                 320 


Pro Ser Asn Thr Ala Cys Cys Ala Arg Cys Asn Thr Pro Pro Asn Leu 
                325                 330                 335     


Lys Gly Arg Tyr Ile Gly Glu Leu Asp Gln Asn Tyr Phe Thr Cys Tyr 
            340                 345                 350         


Ala Pro Val Ile Val Glu Pro Pro Ala Asp Leu Asn Val Thr Glu Gly 
        355                 360                 365             


Met Ala Ala Glu Leu Lys Cys Arg Ala Ser Thr Ser Leu Thr Ser Val 
    370                 375                 380                 


Ser Trp Ile Thr Pro Asn Gly Thr Val Met Thr His Gly Ala Tyr Lys 
385                 390                 395                 400 


Val Arg Ile Ala Val Leu Ser Asp Gly Thr Leu Asn Phe Thr Asn Val 
                405                 410                 415     


Thr Val Gln Asp Thr Gly Met Tyr Thr Cys Met Val Ser Asn Ser Val 
            420                 425                 430         


Gly Asn Thr Thr Ala Ser Ala Thr Leu Asn Val Thr Ala Ala Thr Thr 
        435                 440                 445             


Thr Pro Phe Ser Tyr Phe Ser Thr Val Thr Val Glu Thr Met Glu Pro 
    450                 455                 460                 


Ser Gln Asp Glu Ala Arg Thr Thr Asp Asn Asn Val Gly Pro Thr Pro 
465                 470                 475                 480 


Val Val Asp Trp Glu Thr Thr Asn Val Thr Thr Ser Leu Thr Pro Gln 
                485                 490                 495     


Ser Thr Arg Ser Thr Glu Lys Thr Phe Thr Ile Pro Val Thr Asp Ile 
            500                 505                 510         


Asn Ser Gly Ile Pro Gly Ile Asp Glu Val Met Lys Thr Thr Lys Ile 
        515                 520                 525             


Ile Ile Gly Cys Phe Val Ala Ile Thr Leu Met Ala Ala Val Met Leu 
    530                 535                 540                 


Val Ile Phe Tyr Lys Met Arg Lys Gln His His Arg Gln Asn His His 
545                 550                 555                 560 


Ala Pro Thr Arg Thr Val Glu Ile Ile Asn Val Asp Asp Glu Ile Thr 
                565                 570                 575     


Gly Asp Thr Pro Met Glu Ser His Leu Pro Met Pro Ala Ile Glu His 
            580                 585                 590         


Glu His Leu Asn His Tyr Asn Ser Tyr Lys Ser Pro Phe Asn His Thr 
        595                 600                 605             


Thr Thr Val Asn Thr Ile Asn Ser Ile His Ser Ser Val His Glu Pro 
    610                 615                 620                 


Leu Leu Ile Arg Met Asn Ser Lys Asp Asn Val Gln Glu Thr Gln Ile 
625                 630                 635                 640 


<210>  4743
<211>  2048
<212>  PRT
<213>  Homo sapiens

<400>  4743

Met Ser Gly Arg Gln Arg Thr Leu Phe Gln Thr Trp Gly Ser Ser Ile 
1               5                   10                  15      


Ser Arg Ser Ser Gly Thr Pro Gly Cys Ser Ser Gly Thr Glu Arg Pro 
            20                  25                  30          


Gln Ser Pro Gly Ser Ser Lys Ala Pro Leu Pro Ala Ala Ala Glu Ala 
        35                  40                  45              


Gln Leu Glu Ser Asp Asp Asp Val Leu Leu Val Ala Ala Tyr Glu Ala 
    50                  55                  60                  


Glu Arg Gln Leu Cys Leu Glu Asn Gly Gly Phe Cys Thr Ser Ala Gly 
65                  70                  75                  80  


Ala Leu Trp Ile Tyr Pro Thr Asn Cys Pro Val Arg Asp Tyr Gln Leu 
                85                  90                  95      


His Ile Ser Arg Ala Ala Leu Phe Cys Asn Thr Leu Val Cys Leu Pro 
            100                 105                 110         


Thr Gly Leu Gly Lys Thr Phe Ile Ala Ala Val Val Met Tyr Asn Phe 
        115                 120                 125             


Tyr Arg Trp Phe Pro Ser Gly Lys Val Val Phe Met Ala Pro Thr Lys 
    130                 135                 140                 


Pro Leu Val Thr Gln Gln Ile Glu Ala Cys Tyr Gln Val Met Gly Ile 
145                 150                 155                 160 


Pro Gln Ser His Met Ala Glu Met Thr Gly Ser Thr Gln Ala Ser Thr 
                165                 170                 175     


Arg Lys Glu Ile Trp Cys Ser Lys Arg Val Leu Phe Leu Thr Pro Gln 
            180                 185                 190         


Val Met Val Asn Asp Leu Ser Arg Gly Ala Cys Pro Ala Ala Glu Ile 
        195                 200                 205             


Lys Cys Leu Val Ile Asp Glu Ala His Lys Ala Leu Gly Asn Tyr Ala 
    210                 215                 220                 


Tyr Cys Gln Val Val Arg Glu Leu Val Lys Tyr Thr Asn His Phe Arg 
225                 230                 235                 240 


Ile Leu Ala Leu Ser Ala Thr Pro Gly Ser Asp Ile Lys Ala Val Gln 
                245                 250                 255     


Gln Val Ile Thr Asn Leu Leu Ile Gly Gln Ile Glu Leu Arg Ser Glu 
            260                 265                 270         


Asp Ser Pro Asp Ile Leu Thr Tyr Ser His Glu Arg Lys Val Glu Lys 
        275                 280                 285             


Leu Ile Val Pro Leu Gly Glu Glu Leu Ala Ala Ile Gln Lys Thr Tyr 
    290                 295                 300                 


Ile Gln Ile Leu Glu Ser Phe Ala Arg Ser Leu Ile Gln Arg Asn Val 
305                 310                 315                 320 


Leu Met Arg Arg Asp Ile Pro Asn Leu Thr Lys Tyr Gln Ile Ile Leu 
                325                 330                 335     


Ala Arg Asp Gln Phe Arg Lys Asn Pro Ser Pro Asn Ile Val Gly Ile 
            340                 345                 350         


Gln Gln Gly Ile Ile Glu Gly Glu Phe Ala Ile Cys Ile Ser Leu Tyr 
        355                 360                 365             


His Gly Tyr Glu Leu Leu Gln Gln Met Gly Met Arg Ser Leu Tyr Phe 
    370                 375                 380                 


Phe Leu Cys Gly Ile Met Asp Gly Thr Lys Gly Met Thr Arg Ser Lys 
385                 390                 395                 400 


Asn Glu Leu Gly Arg Asn Glu Asp Phe Met Lys Leu Tyr Asn His Leu 
                405                 410                 415     


Glu Cys Met Phe Ala Arg Thr Arg Ser Thr Ser Ala Asn Gly Ile Ser 
            420                 425                 430         


Ala Ile Gln Gln Gly Asp Lys Asn Lys Lys Phe Val Tyr Ser His Pro 
        435                 440                 445             


Lys Leu Lys Lys Leu Glu Glu Val Val Ile Glu His Phe Lys Ser Trp 
    450                 455                 460                 


Asn Ala Glu Asn Thr Thr Glu Lys Lys Arg Asp Glu Thr Arg Val Met 
465                 470                 475                 480 


Ile Phe Ser Ser Phe Arg Asp Ser Val Gln Glu Ile Ala Glu Met Leu 
                485                 490                 495     


Ser Gln His Gln Pro Ile Ile Arg Val Met Thr Phe Val Gly His Ala 
            500                 505                 510         


Ser Gly Lys Ser Thr Lys Gly Phe Thr Gln Lys Glu Gln Leu Glu Val 
        515                 520                 525             


Val Lys Gln Phe Arg Asp Gly Gly Tyr Asn Thr Leu Val Ser Thr Cys 
    530                 535                 540                 


Val Gly Glu Glu Gly Leu Asp Ile Gly Glu Val Asp Leu Ile Ile Cys 
545                 550                 555                 560 


Phe Asp Ser Gln Lys Ser Pro Ile Arg Leu Val Gln Arg Met Gly Arg 
                565                 570                 575     


Thr Gly Arg Lys Arg Gln Gly Arg Ile Val Ile Ile Leu Ser Glu Gly 
            580                 585                 590         


Arg Glu Glu Arg Ile Tyr Asn Gln Ser Gln Ser Asn Lys Arg Ser Ile 
        595                 600                 605             


Tyr Lys Ala Ile Ser Ser Asn Arg Gln Val Leu His Phe Tyr Gln Arg 
    610                 615                 620                 


Ser Pro Arg Met Val Pro Asp Gly Ile Asn Pro Lys Leu His Lys Met 
625                 630                 635                 640 


Phe Ile Thr His Gly Val Tyr Glu Pro Glu Lys Pro Ser Arg Asn Leu 
                645                 650                 655     


Gln Arg Lys Ser Ser Ile Phe Ser Tyr Arg Asp Gly Met Arg Gln Ser 
            660                 665                 670         


Ser Leu Lys Lys Asp Trp Phe Leu Ser Glu Glu Glu Phe Lys Leu Trp 
        675                 680                 685             


Asn Arg Leu Tyr Arg Leu Arg Asp Ser Asp Glu Ile Lys Glu Ile Thr 
    690                 695                 700                 


Leu Pro Gln Val Gln Phe Ser Ser Leu Gln Asn Glu Glu Asn Lys Pro 
705                 710                 715                 720 


Ala Gln Glu Ser Thr Thr Gly Ile His Gln Leu Ser Leu Ser Glu Trp 
                725                 730                 735     


Arg Leu Trp Gln Asp His Pro Leu Pro Thr His Gln Val Asp His Ser 
            740                 745                 750         


Asp Arg Cys Arg His Phe Ile Gly Leu Met Gln Met Ile Glu Gly Met 
        755                 760                 765             


Arg His Glu Glu Gly Glu Cys Ser Tyr Glu Leu Glu Val Glu Ser Tyr 
    770                 775                 780                 


Leu Gln Met Glu Asp Val Thr Ser Thr Phe Ile Ala Pro Arg Asn Glu 
785                 790                 795                 800 


Ser Asn Asn Leu Ala Ser Asp Thr Phe Ile Thr His Lys Lys Ser Ser 
                805                 810                 815     


Phe Ile Lys Asn Ile Asn Gln Gly Ser Ser Ser Ser Val Ile Glu Ser 
            820                 825                 830         


Asp Glu Glu Cys Ala Glu Ile Val Lys Gln Thr His Ile Lys Pro Thr 
        835                 840                 845             


Lys Ile Val Ser Leu Lys Lys Lys Val Ser Lys Glu Ile Lys Lys Asp 
    850                 855                 860                 


Gln Leu Lys Lys Glu Asn Asn His Gly Ile Ile Asp Ser Val Asp Asn 
865                 870                 875                 880 


Asp Arg Asn Ser Thr Val Glu Asn Ile Phe Gln Glu Asp Leu Pro Asn 
                885                 890                 895     


Asp Lys Arg Thr Ser Asp Thr Asp Glu Ile Ala Ala Thr Cys Thr Ile 
            900                 905                 910         


Asn Glu Asn Val Ile Lys Glu Pro Cys Val Leu Leu Thr Glu Cys Gln 
        915                 920                 925             


Phe Thr Asn Lys Ser Thr Ser Ser Leu Ala Gly Asn Val Leu Asp Ser 
    930                 935                 940                 


Gly Tyr Asn Ser Phe Asn Asp Glu Lys Ser Val Ser Ser Asn Leu Phe 
945                 950                 955                 960 


Leu Pro Phe Glu Glu Glu Leu Tyr Ile Val Arg Thr Asp Asp Gln Phe 
                965                 970                 975     


Tyr Asn Cys His Ser Leu Thr Lys Glu Val Leu Ala Asn Val Glu Arg 
            980                 985                 990         


Phe Leu Ser Tyr Ser Pro Pro Pro  Leu Ser Gly Leu Ser  Asp Leu Glu 
        995                 1000                 1005             


Tyr Glu  Ile Ala Lys Gly Thr  Ala Leu Glu Asn Leu  Leu Phe Leu 
    1010                 1015                 1020             


Pro Cys  Ala Glu His Leu Arg  Ser Asp Lys Cys Thr  Cys Leu Leu 
    1025                 1030                 1035             


Ser His  Ser Ala Val Asn Ser  Gln Gln Asn Leu Glu  Leu Asn Ser 
    1040                 1045                 1050             


Leu Lys  Cys Ile Asn Tyr Pro  Ser Glu Lys Ser Cys  Leu Tyr Asp 
    1055                 1060                 1065             


Ile Pro  Asn Asp Asn Ile Ser  Asp Glu Pro Ser Leu  Cys Asp Cys 
    1070                 1075                 1080             


Asp Val  His Lys His Asn Gln  Asn Glu Asn Leu Val  Pro Asn Asn 
    1085                 1090                 1095             


Arg Val  Gln Ile His Arg Ser  Pro Ala Gln Asn Leu  Val Gly Glu 
    1100                 1105                 1110             


Asn Asn  His Asp Val Asp Asn  Ser Asp Leu Pro Val  Leu Ser Thr 
    1115                 1120                 1125             


Asp Gln  Asp Glu Ser Leu Leu  Leu Phe Glu Asp Val  Asn Thr Glu 
    1130                 1135                 1140             


Phe Asp  Asp Val Ser Leu Ser  Pro Leu Asn Ser Lys  Ser Glu Ser 
    1145                 1150                 1155             


Leu Pro  Val Ser Asp Lys Thr  Ala Ile Ser Glu Thr  Pro Leu Val 
    1160                 1165                 1170             


Ser Gln  Phe Leu Ile Ser Asp  Glu Leu Leu Leu Asp  Asn Asn Ser 
    1175                 1180                 1185             


Glu Leu  Gln Asp Gln Ile Thr  Arg Asp Ala Asn Ser  Phe Lys Ser 
    1190                 1195                 1200             


Arg Asp  Gln Arg Gly Val Gln  Glu Glu Lys Val Lys  Asn His Glu 
    1205                 1210                 1215             


Asp Ile  Phe Asp Cys Ser Arg  Asp Leu Phe Ser Val  Thr Phe Asp 
    1220                 1225                 1230             


Leu Gly  Phe Cys Ser Pro Asp  Ser Asp Asp Glu Ile  Leu Glu His 
    1235                 1240                 1245             


Thr Ser  Asp Ser Asn Arg Pro  Leu Asp Asp Leu Tyr  Gly Arg Tyr 
    1250                 1255                 1260             


Leu Glu  Ile Lys Glu Ile Ser  Asp Ala Asn Tyr Val  Ser Asn Gln 
    1265                 1270                 1275             


Ala Leu  Ile Pro Arg Asp His  Ser Lys Asn Phe Thr  Ser Gly Thr 
    1280                 1285                 1290             


Val Ile  Ile Pro Ser Asn Glu  Asp Met Gln Asn Pro  Asn Tyr Val 
    1295                 1300                 1305             


His Leu  Pro Leu Ser Ala Ala  Lys Asn Glu Glu Leu  Leu Ser Pro 
    1310                 1315                 1320             


Gly Tyr  Ser Gln Phe Ser Leu  Pro Val Gln Lys Lys  Val Met Ser 
    1325                 1330                 1335             


Thr Pro  Leu Ser Lys Ser Asn  Thr Leu Asn Ser Phe  Ser Lys Ile 
    1340                 1345                 1350             


Arg Lys  Glu Ile Leu Lys Thr  Pro Asp Ser Ser Lys  Glu Lys Val 
    1355                 1360                 1365             


Asn Leu  Gln Arg Phe Lys Glu  Ala Leu Asn Ser Thr  Phe Asp Tyr 
    1370                 1375                 1380             


Ser Glu  Phe Ser Leu Glu Lys  Ser Lys Ser Ser Gly  Pro Met Tyr 
    1385                 1390                 1395             


Leu His  Lys Ser Cys His Ser  Val Glu Asp Gly Gln  Leu Leu Thr 
    1400                 1405                 1410             


Ser Asn  Glu Ser Glu Asp Asp  Glu Ile Phe Arg Arg  Lys Val Lys 
    1415                 1420                 1425             


Arg Ala  Lys Gly Asn Val Leu  Asn Ser Pro Glu Asp  Gln Lys Asn 
    1430                 1435                 1440             


Ser Glu  Val Asp Ser Pro Leu  His Ala Val Lys Lys  Arg Arg Phe 
    1445                 1450                 1455             


Pro Ile  Asn Arg Ser Glu Leu  Ser Ser Ser Asp Glu  Ser Glu Asn 
    1460                 1465                 1470             


Phe Pro  Lys Pro Cys Ser Gln  Leu Glu Asp Phe Lys  Val Cys Asn 
    1475                 1480                 1485             


Gly Asn  Ala Arg Arg Gly Ile  Lys Val Pro Lys Arg  Gln Ser His 
    1490                 1495                 1500             


Leu Lys  His Val Ala Arg Lys  Phe Leu Asp Asp Glu  Ala Glu Leu 
    1505                 1510                 1515             


Ser Glu  Glu Asp Ala Glu Tyr  Val Ser Ser Asp Glu  Asn Asp Glu 
    1520                 1525                 1530             


Ser Glu  Asn Glu Gln Asp Ser  Ser Leu Leu Asp Phe  Leu Asn Asp 
    1535                 1540                 1545             


Glu Thr  Gln Leu Ser Gln Ala  Ile Asn Asp Ser Glu  Met Arg Ala 
    1550                 1555                 1560             


Ile Tyr  Met Lys Ser Leu Arg  Ser Pro Met Met Asn  Asn Lys Tyr 
    1565                 1570                 1575             


Lys Met  Ile His Lys Thr His  Lys Asn Ile Asn Ile  Phe Ser Gln 
    1580                 1585                 1590             


Ile Pro  Glu Gln Asp Glu Thr  Tyr Leu Glu Asp Ser  Phe Cys Val 
    1595                 1600                 1605             


Asp Glu  Glu Glu Ser Cys Lys  Gly Gln Ser Ser Glu  Glu Glu Val 
    1610                 1615                 1620             


Cys Val  Asp Phe Asn Leu Ile  Thr Asp Asp Cys Phe  Ala Asn Ser 
    1625                 1630                 1635             


Lys Lys  Tyr Lys Thr Arg Arg  Ala Val Met Leu Lys  Glu Met Met 
    1640                 1645                 1650             


Glu Gln  Asn Cys Ala His Ser  Lys Lys Lys Leu Ser  Arg Ile Ile 
    1655                 1660                 1665             


Leu Pro  Asp Asp Ser Ser Glu  Glu Glu Asn Asn Val  Asn Asp Lys 
    1670                 1675                 1680             


Arg Glu  Ser Asn Ile Ala Val  Asn Pro Ser Thr Val  Lys Lys Asn 
    1685                 1690                 1695             


Lys Gln  Gln Asp His Cys Leu  Asn Ser Val Pro Ser  Gly Ser Ser 
    1700                 1705                 1710             


Ala Gln  Ser Lys Val Arg Ser  Thr Pro Arg Val Asn  Pro Leu Ala 
    1715                 1720                 1725             


Lys Gln  Ser Lys Gln Thr Ser  Leu Asn Leu Lys Asp  Thr Ile Ser 
    1730                 1735                 1740             


Glu Val  Ser Asp Phe Lys Pro  Gln Asn His Asn Glu  Val Gln Ser 
    1745                 1750                 1755             


Thr Thr  Pro Pro Phe Thr Thr  Val Asp Ser Gln Lys  Asp Cys Arg 
    1760                 1765                 1770             


Lys Phe  Pro Val Pro Gln Lys  Asp Gly Ser Ala Leu  Glu Asp Ser 
    1775                 1780                 1785             


Ser Thr  Ser Gly Ala Ser Cys  Ser Lys Ser Arg Pro  His Leu Ala 
    1790                 1795                 1800             


Gly Thr  His Thr Ser Leu Arg  Leu Pro Gln Glu Gly  Lys Gly Thr 
    1805                 1810                 1815             


Cys Ile  Leu Val Gly Gly His  Glu Ile Thr Ser Gly  Leu Glu Val 
    1820                 1825                 1830             


Ile Ser  Ser Leu Arg Ala Ile  His Gly Leu Gln Val  Glu Val Cys 
    1835                 1840                 1845             


Pro Leu  Asn Gly Cys Asp Tyr  Ile Val Ser Asn Arg  Met Val Val 
    1850                 1855                 1860             


Glu Arg  Arg Ser Gln Ser Glu  Met Leu Asn Ser Val  Asn Lys Asn 
    1865                 1870                 1875             


Lys Phe  Ile Glu Gln Ile Gln  His Leu Gln Ser Met  Phe Glu Arg 
    1880                 1885                 1890             


Ile Cys  Val Ile Val Glu Lys  Asp Arg Glu Lys Thr  Gly Asp Thr 
    1895                 1900                 1905             


Ser Arg  Met Phe Arg Arg Thr  Lys Ser Tyr Asp Ser  Leu Leu Thr 
    1910                 1915                 1920             


Thr Leu  Ile Gly Ala Gly Ile  Arg Ile Leu Phe Ser  Ser Cys Gln 
    1925                 1930                 1935             


Glu Glu  Thr Ala Asp Leu Leu  Lys Glu Leu Ser Leu  Val Glu Gln 
    1940                 1945                 1950             


Arg Lys  Asn Val Gly Ile His  Val Pro Thr Val Val  Asn Ser Asn 
    1955                 1960                 1965             


Lys Ser  Glu Ala Leu Gln Phe  Tyr Leu Ser Ile Pro  Asn Ile Ser 
    1970                 1975                 1980             


Tyr Ile  Thr Ala Leu Asn Met  Cys His Gln Phe Ser  Ser Val Lys 
    1985                 1990                 1995             


Arg Met  Ala Asn Ser Ser Leu  Gln Glu Ile Ser Met  Tyr Ala Gln 
    2000                 2005                 2010             


Val Thr  His Gln Lys Ala Glu  Glu Ile Tyr Arg Tyr  Ile His Tyr 
    2015                 2020                 2025             


Val Phe  Asp Ile Gln Met Leu  Pro Asn Asp Leu Asn  Gln Asp Arg 
    2030                 2035                 2040             


Leu Lys  Ser Asp Ile 
    2045             


<210>  4744
<211>  771
<212>  PRT
<213>  Homo sapiens

<400>  4744

Met Ser Gly Phe Phe Thr Ser Leu Asp Pro Arg Arg Val Gln Trp Gly 
1               5                   10                  15      


Ala Ala Trp Tyr Ala Met His Ser Arg Ile Leu Arg Thr Lys Pro Val 
            20                  25                  30          


Glu Ser Met Leu Glu Gly Thr Gly Thr Thr Thr Ala His Gly Thr Lys 
        35                  40                  45              


Leu Ala Gln Val Leu Thr Thr Val Asp Leu Ile Ser Leu Gly Val Gly 
    50                  55                  60                  


Ser Cys Val Gly Thr Gly Met Tyr Val Val Ser Gly Leu Val Ala Lys 
65                  70                  75                  80  


Glu Met Ala Gly Pro Gly Val Ile Val Ser Phe Ile Ile Ala Ala Val 
                85                  90                  95      


Ala Ser Ile Leu Ser Gly Val Cys Tyr Ala Glu Phe Gly Val Arg Val 
            100                 105                 110         


Pro Lys Thr Thr Gly Ser Ala Tyr Thr Tyr Ser Tyr Val Thr Val Gly 
        115                 120                 125             


Glu Phe Val Ala Phe Phe Ile Gly Trp Asn Leu Ile Leu Glu Tyr Leu 
    130                 135                 140                 


Ile Gly Thr Ala Ala Gly Ala Ser Ala Leu Ser Ser Met Phe Asp Ser 
145                 150                 155                 160 


Leu Ala Asn His Thr Ile Ser Arg Trp Met Ala Asp Ser Val Gly Thr 
                165                 170                 175     


Leu Asn Gly Leu Gly Lys Gly Glu Glu Ser Tyr Pro Asp Leu Leu Ala 
            180                 185                 190         


Leu Leu Ile Ala Val Ile Val Thr Ile Ile Val Ala Leu Gly Val Lys 
        195                 200                 205             


Asn Ser Ile Gly Phe Asn Asn Val Leu Asn Val Leu Asn Leu Ala Val 
    210                 215                 220                 


Trp Val Phe Ile Met Ile Ala Gly Leu Phe Phe Ile Asn Gly Lys Tyr 
225                 230                 235                 240 


Trp Ala Glu Gly Gln Phe Leu Pro His Gly Trp Ser Gly Val Leu Gln 
                245                 250                 255     


Gly Ala Ala Thr Cys Phe Tyr Ala Phe Ile Gly Phe Asp Ile Ile Ala 
            260                 265                 270         


Thr Thr Gly Glu Glu Ala Lys Asn Pro Asn Thr Ser Ile Pro Tyr Ala 
        275                 280                 285             


Ile Thr Ala Ser Leu Val Ile Cys Leu Thr Ala Tyr Val Ser Val Ser 
    290                 295                 300                 


Val Ile Leu Thr Leu Met Val Pro Tyr Tyr Thr Ile Asp Thr Glu Ser 
305                 310                 315                 320 


Pro Leu Met Glu Met Phe Val Ala His Gly Phe Tyr Ala Ala Lys Phe 
                325                 330                 335     


Val Val Ala Ile Gly Ser Val Ala Gly Leu Thr Val Ser Leu Leu Gly 
            340                 345                 350         


Ser Leu Phe Pro Met Pro Arg Val Ile Tyr Ala Met Ala Gly Asp Gly 
        355                 360                 365             


Leu Leu Phe Arg Phe Leu Ala His Val Ser Ser Tyr Thr Glu Thr Pro 
    370                 375                 380                 


Val Val Ala Cys Ile Val Ser Gly Phe Leu Ala Ala Leu Leu Ala Leu 
385                 390                 395                 400 


Leu Val Ser Leu Arg Asp Leu Ile Glu Met Met Ser Ile Gly Thr Leu 
                405                 410                 415     


Leu Ala Tyr Thr Leu Val Ser Val Cys Val Leu Leu Leu Arg Tyr Gln 
            420                 425                 430         


Pro Glu Ser Asp Ile Asp Gly Phe Val Lys Phe Leu Ser Glu Glu His 
        435                 440                 445             


Thr Lys Lys Lys Glu Gly Ile Leu Ala Asp Cys Glu Lys Glu Ala Cys 
    450                 455                 460                 


Ser Pro Val Ser Glu Gly Asp Glu Phe Ser Gly Pro Ala Thr Asn Thr 
465                 470                 475                 480 


Cys Gly Ala Lys Asn Leu Pro Ser Leu Gly Asp Asn Glu Met Leu Ile 
                485                 490                 495     


Gly Lys Ser Asp Lys Ser Thr Tyr Asn Val Asn His Pro Asn Tyr Gly 
            500                 505                 510         


Thr Val Asp Met Thr Thr Gly Ile Glu Ala Asp Glu Ser Glu Asn Ile 
        515                 520                 525             


Tyr Leu Ile Lys Leu Lys Lys Leu Ile Gly Pro His Tyr Tyr Thr Met 
    530                 535                 540                 


Arg Ile Arg Leu Gly Leu Pro Gly Lys Met Asp Arg Pro Thr Ala Ala 
545                 550                 555                 560 


Thr Gly His Thr Val Thr Ile Cys Val Leu Leu Leu Phe Ile Leu Met 
                565                 570                 575     


Phe Ile Phe Cys Ser Phe Ile Ile Phe Gly Ser Asp Tyr Ile Ser Glu 
            580                 585                 590         


Gln Ser Trp Trp Ala Ile Leu Leu Val Val Leu Met Val Leu Leu Ile 
        595                 600                 605             


Ser Thr Leu Val Phe Val Ile Leu Gln Gln Pro Glu Asn Pro Lys Lys 
    610                 615                 620                 


Leu Pro Tyr Met Ala Pro Cys Leu Pro Phe Val Pro Ala Phe Ala Met 
625                 630                 635                 640 


Leu Val Asn Ile Tyr Leu Met Leu Lys Leu Ser Thr Ile Thr Trp Ile 
                645                 650                 655     


Arg Phe Ala Val Trp Cys Phe Val Gly Leu Leu Ile Tyr Phe Gly Tyr 
            660                 665                 670         


Gly Ile Trp Asn Ser Thr Leu Glu Ile Ser Ala Arg Glu Glu Ala Leu 
        675                 680                 685             


His Gln Ser Thr Tyr Gln Arg Tyr Asp Val Asp Asp Pro Phe Ser Val 
    690                 695                 700                 


Glu Glu Gly Phe Ser Tyr Ala Thr Glu Gly Glu Ser Gln Glu Asp Trp 
705                 710                 715                 720 


Gly Gly Pro Thr Glu Asp Lys Gly Phe Tyr Tyr Gln Gln Met Ser Asp 
                725                 730                 735     


Ala Lys Ala Asn Gly Arg Thr Ser Ser Lys Ala Lys Ser Lys Ser Lys 
            740                 745                 750         


His Lys Gln Asn Ser Glu Ala Leu Ile Ala Asn Asp Glu Leu Asp Tyr 
        755                 760                 765             


Ser Pro Glu 
    770     


<210>  4745
<211>  1554
<212>  PRT
<213>  Homo sapiens

<400>  4745

Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His 
1               5                   10                  15      


Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser 
            20                  25                  30          


Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln 
        35                  40                  45              


Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp 
    50                  55                  60                  


Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp 
65                  70                  75                  80  


Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile 
                85                  90                  95      


Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly 
            100                 105                 110         


Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys 
        115                 120                 125             


Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn 
    130                 135                 140                 


Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu 
145                 150                 155                 160 


Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Ile Gly Gln Gly 
                165                 170                 175     


Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser 
            180                 185                 190         


Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val 
        195                 200                 205             


Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys 
    210                 215                 220                 


Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu 
225                 230                 235                 240 


Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln 
                245                 250                 255     


His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile 
            260                 265                 270         


Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala 
        275                 280                 285             


Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln 
    290                 295                 300                 


Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln 
305                 310                 315                 320 


Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala 
                325                 330                 335     


Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu 
            340                 345                 350         


Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu 
        355                 360                 365             


Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His 
    370                 375                 380                 


Leu Val Arg Asp Val Lys Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile 
385                 390                 395                 400 


Ser Leu Ile Asp Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala 
                405                 410                 415     


Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn 
            420                 425                 430         


Leu Phe Gly Pro Lys Arg Pro Lys Ala Leu Lys Leu Leu Gly Met Glu 
        435                 440                 445             


Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu 
    450                 455                 460                 


Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro 
465                 470                 475                 480 


Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln 
                485                 490                 495     


Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys 
            500                 505                 510         


Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser 
        515                 520                 525             


Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser 
    530                 535                 540                 


Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys 
545                 550                 555                 560 


Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn 
                565                 570                 575     


Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg 
            580                 585                 590         


Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp 
        595                 600                 605             


Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu 
    610                 615                 620                 


Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys 
625                 630                 635                 640 


Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu 
                645                 650                 655     


Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu 
            660                 665                 670         


Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser 
        675                 680                 685             


Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro 
    690                 695                 700                 


Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe 
705                 710                 715                 720 


Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr 
                725                 730                 735     


Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile 
            740                 745                 750         


Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile 
        755                 760                 765             


Leu Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu 
    770                 775                 780                 


Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser 
785                 790                 795                 800 


Val Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly 
                805                 810                 815     


Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu 
            820                 825                 830         


Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile 
        835                 840                 845             


Gly Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val 
    850                 855                 860                 


Val Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn 
865                 870                 875                 880 


Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met Pro Tyr 
                885                 890                 895     


Trp Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Pro Pro Cys 
            900                 905                 910         


Gly Gln Asn Glu Thr Arg Glu Asp Gly Lys Ile Ile Gln Leu Pro Pro 
        915                 920                 925             


Cys Lys Thr Gly Ala Trp Ile Val Pro Ala Ile Met Ala Cys Tyr Leu 
    930                 935                 940                 


Leu Val Ala Asn Ile Leu Leu Val Asn Leu Leu Ile Ala Val Phe Asn 
945                 950                 955                 960 


Asn Thr Phe Phe Glu Val Lys Ser Ile Ser Asn Gln Val Trp Lys Phe 
                965                 970                 975     


Gln Arg Tyr Gln Leu Ile Met Thr Phe His Glu Arg Pro Val Leu Pro 
            980                 985                 990         


Pro Pro Leu Ile Ile Phe Ser His  Met Thr Met Ile Phe  Gln His Leu 
        995                 1000                 1005             


Cys Cys  Arg Trp Arg Lys His  Glu Ser Asp Pro Asp  Glu Arg Asp 
    1010                 1015                 1020             


Tyr Gly  Leu Lys Leu Phe Ile  Thr Asp Asp Glu Leu  Lys Lys Val 
    1025                 1030                 1035             


His Asp  Phe Glu Glu Gln Cys  Ile Glu Glu Tyr Phe  Arg Glu Lys 
    1040                 1045                 1050             


Asp Asp  Arg Phe Asn Ser Ser  Asn Asp Glu Arg Ile  Arg Val Thr 
    1055                 1060                 1065             


Ser Glu  Arg Val Glu Asn Met  Ser Met Arg Leu Glu  Glu Val Asn 
    1070                 1075                 1080             


Glu Arg  Glu His Ser Met Lys  Ala Ser Leu Gln Thr  Val Asp Ile 
    1085                 1090                 1095             


Arg Leu  Ala Gln Leu Glu Asp  Leu Ile Gly Arg Met  Ala Thr Ala 
    1100                 1105                 1110             


Leu Glu  Arg Leu Thr Gly Leu  Glu Arg Ala Glu Ser  Asn Lys Ile 
    1115                 1120                 1125             


Arg Ser  Arg Thr Ser Ser Asp  Cys Thr Asp Ala Ala  Tyr Ile Val 
    1130                 1135                 1140             


Arg Gln  Ser Ser Phe Asn Ser  Gln Glu Gly Asn Thr  Phe Lys Leu 
    1145                 1150                 1155             


Gln Glu  Ser Ile Asp Pro Ala  Gly Glu Glu Thr Met  Ser Pro Thr 
    1160                 1165                 1170             


Ser Pro  Thr Leu Met Pro Arg  Met Arg Ser His Ser  Phe Tyr Ser 
    1175                 1180                 1185             


Val Asn  Met Lys Asp Lys Gly  Gly Ile Glu Lys Leu  Glu Ser Ile 
    1190                 1195                 1200             


Phe Lys  Glu Arg Ser Leu Ser  Leu His Arg Ala Thr  Ser Ser His 
    1205                 1210                 1215             


Ser Val  Ala Lys Glu Pro Lys  Ala Pro Ala Ala Pro  Ala Asn Thr 
    1220                 1225                 1230             


Leu Ala  Ile Val Pro Asp Ser  Arg Arg Pro Ser Ser  Cys Ile Asp 
    1235                 1240                 1245             


Ile Tyr  Val Ser Ala Met Asp  Glu Leu His Cys Asp  Ile Asp Pro 
    1250                 1255                 1260             


Leu Asp  Asn Ser Val Asn Ile  Leu Gly Leu Gly Glu  Pro Ser Phe 
    1265                 1270                 1275             


Ser Thr  Pro Val Pro Ser Thr  Ala Pro Ser Ser Ser  Ala Tyr Ala 
    1280                 1285                 1290             


Thr Leu  Ala Pro Thr Asp Arg  Pro Pro Ser Arg Ser  Ile Asp Phe 
    1295                 1300                 1305             


Glu Asp  Ile Thr Ser Met Asp  Thr Arg Ser Phe Ser  Ser Asp Tyr 
    1310                 1315                 1320             


Thr His  Leu Pro Glu Cys Gln  Asn Pro Trp Asp Ser  Glu Pro Pro 
    1325                 1330                 1335             


Met Tyr  His Thr Ile Glu Arg  Ser Lys Ser Ser Arg  Tyr Leu Ala 
    1340                 1345                 1350             


Thr Thr  Pro Phe Leu Leu Glu  Glu Ala Pro Ile Val  Lys Ser His 
    1355                 1360                 1365             


Ser Phe  Met Phe Ser Pro Ser  Arg Ser Tyr Tyr Ala  Asn Phe Gly 
    1370                 1375                 1380             


Val Pro  Val Lys Thr Ala Glu  Tyr Thr Ser Ile Thr  Asp Cys Ile 
    1385                 1390                 1395             


Asp Thr  Arg Cys Val Asn Ala  Pro Gln Ala Ile Ala  Asp Arg Ala 
    1400                 1405                 1410             


Ala Phe  Pro Gly Gly Leu Gly  Asp Lys Val Glu Asp  Leu Thr Cys 
    1415                 1420                 1425             


Cys His  Pro Glu Arg Glu Ala  Glu Leu Ser His Pro  Ser Ser Asp 
    1430                 1435                 1440             


Ser Glu  Glu Asn Glu Ala Lys  Gly Arg Arg Ala Thr  Ile Ala Ile 
    1445                 1450                 1455             


Ser Ser  Gln Glu Gly Asp Asn  Ser Glu Arg Thr Leu  Ser Asn Asn 
    1460                 1465                 1470             


Ile Thr  Val Pro Lys Ile Glu  Arg Ala Asn Ser Tyr  Ser Ala Glu 
    1475                 1480                 1485             


Glu Pro  Ser Ala Pro Tyr Ala  His Thr Arg Lys Ser  Phe Ser Ile 
    1490                 1495                 1500             


Ser Asp  Lys Leu Asp Arg Gln  Arg Asn Thr Ala Ser  Leu Arg Asn 
    1505                 1510                 1515             


Pro Phe  Gln Arg Ser Lys Ser  Ser Lys Pro Glu Gly  Arg Gly Asp 
    1520                 1525                 1530             


Ser Leu  Ser Met Arg Arg Leu  Ser Arg Thr Ser Ala  Phe Gln Ser 
    1535                 1540                 1545             


Phe Glu  Ser Lys His Asn 
    1550                 


<210>  4746
<211>  776
<212>  PRT
<213>  Homo sapiens

<400>  4746

Met Glu Ile Gly Trp Met His Asn Arg Arg Gln Arg Gln Val Leu Val 
1               5                   10                  15      


Phe Phe Val Leu Leu Ser Leu Ser Gly Ala Gly Ala Glu Leu Gly Ser 
            20                  25                  30          


Tyr Ser Val Val Glu Glu Thr Glu Arg Gly Ser Phe Val Ala Asn Leu 
        35                  40                  45              


Gly Lys Asp Leu Gly Leu Gly Leu Thr Glu Met Ser Thr Arg Lys Ala 
    50                  55                  60                  


Arg Ile Ile Ser Gln Gly Asn Lys Gln His Leu Gln Leu Lys Ala Gln 
65                  70                  75                  80  


Thr Gly Asp Leu Leu Ile Asn Glu Lys Leu Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Pro Thr Glu Pro Cys Ile Leu His Phe Gln Val Leu Met Glu Asn 
            100                 105                 110         


Pro Leu Glu Ile Phe Gln Ala Glu Leu Arg Val Ile Asp Ile Asn Asp 
        115                 120                 125             


His Ser Pro Met Phe Thr Glu Lys Glu Met Ile Leu Lys Ile Pro Glu 
    130                 135                 140                 


Asn Ser Pro Leu Gly Thr Glu Phe Pro Leu Asn His Ala Leu Asp Leu 
145                 150                 155                 160 


Asp Val Gly Ser Asn Asn Val Gln Asn Tyr Lys Ile Ser Pro Ser Ser 
                165                 170                 175     


His Phe Arg Val Leu Ile His Glu Phe Arg Asp Gly Arg Lys Tyr Pro 
            180                 185                 190         


Glu Leu Val Leu Asp Lys Glu Leu Asp Arg Glu Glu Glu Pro Gln Leu 
        195                 200                 205             


Arg Leu Thr Leu Thr Ala Leu Asp Gly Gly Ser Pro Pro Arg Ser Gly 
    210                 215                 220                 


Thr Ala Gln Val Arg Ile Glu Val Val Asp Ile Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Glu Phe Glu Gln Pro Ile Tyr Lys Val Gln Ile Pro Glu Asn Ser Pro 
                245                 250                 255     


Leu Gly Ser Leu Val Ala Thr Val Ser Ala Arg Asp Leu Asp Gly Gly 
            260                 265                 270         


Ala Asn Gly Lys Ile Ser Tyr Thr Leu Phe Gln Pro Ser Glu Asp Ile 
        275                 280                 285             


Ser Lys Thr Leu Glu Val Asn Pro Met Thr Gly Glu Val Arg Leu Arg 
    290                 295                 300                 


Lys Gln Val Asp Phe Glu Met Val Thr Ser Tyr Glu Val Arg Ile Lys 
305                 310                 315                 320 


Ala Thr Asp Gly Gly Gly Leu Ser Gly Lys Cys Thr Leu Leu Leu Gln 
                325                 330                 335     


Val Val Asp Val Asn Asp Asn Pro Pro Gln Val Thr Met Ser Ala Leu 
            340                 345                 350         


Thr Ser Pro Ile Pro Glu Asn Ser Pro Glu Ile Val Val Ala Val Phe 
        355                 360                 365             


Ser Val Ser Asp Pro Asp Ser Gly Asn Asn Gly Lys Thr Ile Ser Ser 
    370                 375                 380                 


Ile Gln Glu Asp Leu Pro Phe Leu Leu Lys Pro Ser Val Lys Asn Phe 
385                 390                 395                 400 


Tyr Thr Leu Val Thr Glu Arg Ala Leu Asp Arg Glu Ala Arg Ala Glu 
                405                 410                 415     


Tyr Asn Ile Thr Leu Thr Val Thr Asp Met Gly Thr Pro Arg Leu Lys 
            420                 425                 430         


Thr Glu His Asn Ile Thr Val Gln Ile Ser Asp Val Asn Asp Asn Ala 
        435                 440                 445             


Pro Thr Phe Thr Gln Thr Ser Tyr Thr Leu Phe Val Arg Glu Asn Asn 
    450                 455                 460                 


Ser Pro Ala Leu His Ile Gly Ser Val Ser Ala Thr Asp Arg Asp Ser 
465                 470                 475                 480 


Gly Thr Asn Ala Gln Val Thr Tyr Ser Leu Leu Pro Pro Gln Asp Pro 
                485                 490                 495     


His Leu Pro Leu Ala Ser Leu Val Ser Ile Asn Ala Asp Asn Gly His 
            500                 505                 510         


Leu Phe Ala Leu Arg Ser Leu Asp Tyr Glu Ala Leu Gln Ala Phe Glu 
        515                 520                 525             


Phe Arg Val Gly Ala Thr Asp Arg Gly Ser Pro Ala Leu Ser Arg Glu 
    530                 535                 540                 


Ala Leu Val Arg Val Leu Val Leu Asp Ala Asn Asp Asn Ser Pro Phe 
545                 550                 555                 560 


Val Leu Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu Leu Val 
                565                 570                 575     


Pro Arg Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val 
            580                 585                 590         


Asp Gly Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu Lys 
        595                 600                 605             


Ala Thr Glu Pro Gly Leu Phe Gly Val Trp Ala His Asn Gly Glu Val 
    610                 615                 620                 


Arg Thr Ala Arg Leu Leu Ser Glu Arg Asp Ala Ala Lys Gln Arg Leu 
625                 630                 635                 640 


Val Val Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr Ala 
                645                 650                 655     


Thr Leu His Val Leu Leu Val Asp Gly Phe Ser Gln Pro Phe Leu Pro 
            660                 665                 670         


Leu Pro Glu Ala Ala Pro Gly Gln Thr Gln Ala Asn Ser Leu Thr Val 
        675                 680                 685             


Tyr Leu Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu Phe Ser 
    690                 695                 700                 


Val Leu Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg Ala Ala 
705                 710                 715                 720 


Ser Val Gly Arg Cys Ser Met Pro Glu Gly Pro Phe Pro Gly Arg Leu 
                725                 730                 735     


Val Asp Val Ser Gly Thr Gly Thr Leu Ser Gln Ser Tyr Gln Tyr Glu 
            740                 745                 750         


Val Cys Leu Thr Gly Gly Ser Glu Thr Ser Glu Phe Lys Phe Leu Lys 
        755                 760                 765             


Pro Ile Ile Pro Asn Phe Ser Pro 
    770                 775     


<210>  4747
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  4747

Met Ala Ala Leu Ala Pro Val Gly Ser Pro Ala Ser Arg Gly Pro Arg 
1               5                   10                  15      


Leu Ala Ala Gly Leu Arg Leu Leu Pro Met Leu Gly Leu Leu Gln Leu 
            20                  25                  30          


Leu Ala Glu Pro Gly Leu Gly Arg Val His His Leu Ala Leu Lys Asp 
        35                  40                  45              


Asp Val Arg His Lys Val His Leu Asn Thr Phe Gly Phe Phe Lys Asp 
    50                  55                  60                  


Gly Tyr Met Val Val Asn Val Ser Ser Leu Ser Leu Asn Glu Pro Glu 
65                  70                  75                  80  


Asp Lys Asp Val Thr Ile Gly Phe Ser Leu Asp Arg Thr Lys Asn Asp 
                85                  90                  95      


Gly Phe Ser Ser Tyr Leu Asp Glu Asp Val Asn Tyr Cys Ile Leu Lys 
            100                 105                 110         


Lys Gln Ser Val Ser Val Thr Leu Leu Ile Leu Asp Ile Ser Arg Ser 
        115                 120                 125             


Glu Val Arg Val Lys Ser Pro Pro Glu Ala Gly Thr Gln Leu Pro Lys 
    130                 135                 140                 


Ile Ile Phe Ser Arg Asp Glu Lys Val Leu Gly Gln Ser Gln Glu Pro 
145                 150                 155                 160 


Asn Val Asn Pro Ala Ser Ala Gly Asn Gln Thr Gln Lys Thr Gln Asp 
                165                 170                 175     


Gly Gly Lys Ser Lys Arg Ser Thr Val Asp Ser Lys Ala Met Gly Glu 
            180                 185                 190         


Lys Ser Phe Ser Val His Asn Asn Gly Gly Ala Val Ser Phe Gln Phe 
        195                 200                 205             


Phe Phe Asn Ile Ser Thr Asp Asp Gln Glu Gly Leu Tyr Ser Leu Tyr 
    210                 215                 220                 


Phe His Lys Cys Leu Gly Lys Glu Leu Pro Ser Asp Lys Phe Thr Phe 
225                 230                 235                 240 


Ser Leu Asp Ile Glu Ile Thr Glu Lys Asn Pro Asp Ser Tyr Leu Ser 
                245                 250                 255     


Ala Gly Glu Ile Pro Leu Pro Lys Leu Tyr Ile Ser Met Ala Phe Phe 
            260                 265                 270         


Phe Phe Leu Ser Gly Thr Ile Trp Ile His Ile Leu Arg Lys Arg Arg 
        275                 280                 285             


Asn Asp Val Phe Lys Ile His Trp Leu Met Ala Ala Leu Pro Phe Thr 
    290                 295                 300                 


Lys Ser Leu Ser Leu Val Phe His Ala Ile Asp Tyr His Tyr Ile Ser 
305                 310                 315                 320 


Ser Gln Gly Phe Pro Ile Glu Gly Trp Ala Val Val Tyr Tyr Ile Thr 
                325                 330                 335     


His Leu Leu Lys Gly Ala Leu Leu Phe Ile Thr Ile Ala Leu Ile Gly 
            340                 345                 350         


Thr Gly Trp Ala Phe Ile Lys His Ile Leu Ser Asp Lys Asp Lys Lys 
        355                 360                 365             


Ile Phe Met Ile Val Ile Pro Leu Gln Val Leu Ala Asn Val Ala Tyr 
    370                 375                 380                 


Ile Ile Ile Glu Ser Thr Glu Glu Gly Thr Thr Glu Tyr Gly Leu Trp 
385                 390                 395                 400 


Lys Asp Ser Leu Phe Leu Val Asp Leu Leu Cys Cys Gly Ala Ile Leu 
                405                 410                 415     


Phe Pro Val Val Trp Ser Ile Arg His Leu Gln Glu Ala Ser Ala Thr 
            420                 425                 430         


Asp Gly Lys Ala Ala Ile Asn Leu Ala Lys Leu Lys Leu Phe Arg His 
        435                 440                 445             


Tyr Tyr Val Leu Ile Val Cys Tyr Ile Tyr Phe Thr Arg Ile Ile Ala 
    450                 455                 460                 


Phe Leu Leu Lys Leu Ala Val Pro Phe Gln Trp Lys Trp Leu Tyr Gln 
465                 470                 475                 480 


Leu Leu Asp Glu Thr Ala Thr Leu Val Phe Phe Val Leu Thr Gly Tyr 
                485                 490                 495     


Lys Phe Arg Pro Ala Ser Asp Asn Pro Tyr Leu Gln Leu Ser Gln Glu 
            500                 505                 510         


Glu Glu Asp Leu Glu Met Glu Ser Val Val Thr Thr Ser Gly Val Met 
        515                 520                 525             


Glu Ser Met Lys Lys Val Lys Lys Val Thr Asn Gly Ser Val Glu Pro 
    530                 535                 540                 


Gln Gly Glu Trp Glu Gly Ala Val 
545                 550         


<210>  4748
<211>  1250
<212>  PRT
<213>  Homo sapiens

<400>  4748

Met Ala Arg Gly Asp Ala Gly Arg Gly Arg Gly Leu Leu Ala Leu Thr 
1               5                   10                  15      


Phe Cys Leu Leu Ala Ala Arg Gly Glu Leu Leu Leu Pro Gln Glu Thr 
            20                  25                  30          


Thr Val Glu Leu Ser Cys Gly Val Gly Pro Leu Gln Val Ile Leu Gly 
        35                  40                  45              


Pro Glu Gln Ala Ala Val Leu Asn Cys Ser Leu Gly Ala Ala Ala Ala 
    50                  55                  60                  


Gly Pro Pro Thr Arg Val Thr Trp Ser Lys Asp Gly Asp Thr Leu Leu 
65                  70                  75                  80  


Glu His Asp His Leu His Leu Leu Pro Asn Gly Ser Leu Trp Leu Ser 
                85                  90                  95      


Gln Pro Leu Ala Pro Asn Gly Ser Asp Glu Ser Val Pro Glu Ala Val 
            100                 105                 110         


Gly Val Ile Glu Gly Asn Tyr Ser Cys Leu Ala His Gly Pro Leu Gly 
        115                 120                 125             


Val Leu Ala Ser Gln Thr Ala Val Val Lys Leu Ala Thr Leu Ala Asp 
    130                 135                 140                 


Phe Ser Leu His Pro Glu Ser Gln Thr Val Glu Glu Asn Gly Thr Ala 
145                 150                 155                 160 


Arg Phe Glu Cys His Ile Glu Gly Leu Pro Ala Pro Ile Ile Thr Trp 
                165                 170                 175     


Glu Lys Asp Gln Val Thr Leu Pro Glu Glu Pro Arg Leu Ile Val Leu 
            180                 185                 190         


Pro Asn Gly Val Leu Gln Ile Leu Asp Val Gln Glu Ser Asp Ala Gly 
        195                 200                 205             


Pro Tyr Arg Cys Val Ala Thr Asn Ser Ala Arg Gln His Phe Ser Gln 
    210                 215                 220                 


Glu Ala Leu Leu Ser Val Ala His Arg Gly Ser Leu Ala Ser Thr Arg 
225                 230                 235                 240 


Gly Gln Asp Val Val Ile Val Ala Ala Pro Glu Asn Thr Thr Val Val 
                245                 250                 255     


Ser Gly Gln Ser Val Val Met Glu Cys Val Ala Ser Ala Asp Pro Thr 
            260                 265                 270         


Pro Phe Val Ser Trp Val Arg Gln Asp Gly Lys Pro Ile Ser Thr Asp 
        275                 280                 285             


Val Ile Val Leu Gly Arg Thr Asn Leu Leu Ile Ala Asn Ala Gln Pro 
    290                 295                 300                 


Trp His Ser Gly Val Tyr Val Cys Arg Ala Asn Lys Pro Arg Thr Arg 
305                 310                 315                 320 


Asp Phe Ala Thr Ala Ala Ala Glu Leu Arg Val Leu Ala Ala Pro Ala 
                325                 330                 335     


Ile Thr Gln Ala Pro Glu Ala Leu Ser Arg Thr Arg Ala Ser Thr Ala 
            340                 345                 350         


Arg Phe Val Cys Arg Ala Ser Gly Glu Pro Arg Pro Ala Leu Arg Trp 
        355                 360                 365             


Leu His Asn Gly Ala Pro Leu Arg Pro Asn Gly Arg Val Lys Val Gln 
    370                 375                 380                 


Gly Gly Gly Gly Ser Leu Val Ile Thr Gln Ile Gly Leu Gln Asp Ala 
385                 390                 395                 400 


Gly Tyr Tyr Gln Cys Val Ala Glu Asn Ser Ala Gly Met Ala Cys Ala 
                405                 410                 415     


Ala Ala Ser Leu Ala Val Val Val Arg Glu Gly Leu Pro Ser Ala Pro 
            420                 425                 430         


Thr Arg Val Thr Ala Thr Pro Leu Ser Ser Ser Ala Val Leu Val Ala 
        435                 440                 445             


Trp Glu Arg Pro Glu Met His Ser Glu Gln Ile Ile Gly Phe Ser Leu 
    450                 455                 460                 


His Tyr Gln Lys Ala Arg Gly Met Asp Asn Val Glu Tyr Gln Phe Ala 
465                 470                 475                 480 


Val Asn Asn Asp Thr Thr Glu Leu Gln Val Arg Asp Leu Glu Pro Asn 
                485                 490                 495     


Thr Asp Tyr Glu Phe Tyr Val Val Ala Tyr Ser Gln Leu Gly Ala Ser 
            500                 505                 510         


Arg Thr Ser Thr Pro Ala Leu Val His Thr Leu Asp Asp Val Pro Ser 
        515                 520                 525             


Ala Ala Pro Gln Leu Ser Leu Ser Ser Pro Asn Pro Ser Asp Ile Arg 
    530                 535                 540                 


Val Ala Trp Leu Pro Leu Pro Pro Ser Leu Ser Asn Gly Gln Val Val 
545                 550                 555                 560 


Lys Tyr Lys Ile Glu Tyr Gly Leu Gly Lys Glu Asp Gln Ile Phe Ser 
                565                 570                 575     


Thr Glu Val Arg Gly Asn Glu Thr Gln Leu Met Leu Asn Ser Leu Gln 
            580                 585                 590         


Pro Asn Lys Val Tyr Arg Val Arg Ile Ser Ala Gly Thr Ala Ala Gly 
        595                 600                 605             


Phe Gly Ala Pro Ser Gln Trp Met His His Arg Thr Pro Ser Met His 
    610                 615                 620                 


Asn Gln Ser His Val Pro Phe Ala Pro Ala Glu Leu Lys Val Gln Ala 
625                 630                 635                 640 


Lys Met Glu Ser Leu Val Val Ser Trp Gln Pro Pro Pro His Pro Thr 
                645                 650                 655     


Gln Ile Ser Gly Tyr Lys Leu Tyr Trp Arg Glu Val Gly Ala Glu Glu 
            660                 665                 670         


Glu Ala Asn Gly Asp Arg Leu Pro Gly Gly Arg Gly Asp Gln Ala Trp 
        675                 680                 685             


Asp Val Gly Pro Val Arg Leu Lys Lys Lys Val Lys Gln Tyr Glu Leu 
    690                 695                 700                 


Thr Gln Leu Val Pro Gly Arg Leu Tyr Glu Val Lys Leu Val Ala Phe 
705                 710                 715                 720 


Asn Lys His Glu Asp Gly Tyr Ala Ala Val Trp Lys Gly Lys Thr Glu 
                725                 730                 735     


Lys Ala Pro Ala Pro Asp Met Pro Ile Gln Arg Gly Pro Pro Leu Pro 
            740                 745                 750         


Pro Ala His Val His Ala Glu Ser Asn Ser Ser Thr Ser Ile Trp Leu 
        755                 760                 765             


Arg Trp Lys Lys Pro Asp Phe Thr Thr Val Lys Ile Val Asn Tyr Thr 
    770                 775                 780                 


Val Arg Phe Ser Pro Trp Gly Leu Arg Asn Ala Ser Leu Val Thr Tyr 
785                 790                 795                 800 


Tyr Thr Ser Ser Gly Glu Asp Ile Leu Ile Gly Gly Leu Lys Pro Phe 
                805                 810                 815     


Thr Lys Tyr Glu Phe Ala Val Gln Ser His Gly Val Asp Met Asp Gly 
            820                 825                 830         


Pro Phe Gly Ser Val Val Glu Arg Ser Thr Leu Pro Asp Arg Pro Ser 
        835                 840                 845             


Thr Pro Pro Ser Asp Leu Arg Leu Ser Pro Leu Thr Pro Ser Thr Val 
    850                 855                 860                 


Arg Leu His Trp Cys Pro Pro Thr Glu Pro Asn Gly Glu Ile Val Glu 
865                 870                 875                 880 


Tyr Leu Ile Leu Tyr Ser Ser Asn His Thr Gln Pro Glu His Gln Trp 
                885                 890                 895     


Thr Leu Leu Thr Thr Gln Gly Asn Ile Phe Ser Ala Glu Val His Gly 
            900                 905                 910         


Leu Glu Ser Asp Thr Arg Tyr Phe Phe Lys Met Gly Ala Arg Thr Glu 
        915                 920                 925             


Val Gly Pro Gly Pro Phe Ser Arg Leu Gln Asp Val Ile Thr Leu Gln 
    930                 935                 940                 


Glu Lys Leu Ser Asp Ser Leu Asp Met His Ser Val Thr Gly Ile Ile 
945                 950                 955                 960 


Val Gly Val Cys Leu Gly Leu Leu Cys Leu Leu Ala Cys Met Cys Ala 
                965                 970                 975     


Gly Leu Arg Arg Ser Pro His Arg Glu Ser Leu Pro Gly Leu Ser Ser 
            980                 985                 990         


Thr Ala Thr Pro Gly Asn Pro Ala  Leu Tyr Ser Arg Ala  Arg Leu Gly 
        995                 1000                 1005             


Pro Pro  Ser Pro Pro Ala Ala  His Glu Leu Glu Ser  Leu Val His 
    1010                 1015                 1020             


Pro His  Pro Gln Asp Trp Ser  Pro Pro Pro Ser Asp  Val Glu Asp 
    1025                 1030                 1035             


Arg Ala  Glu Val His Ser Leu  Met Gly Gly Gly Val  Ser Glu Gly 
    1040                 1045                 1050             


Arg Ser  His Ser Lys Arg Lys  Ile Ser Trp Ala Gln  Pro Ser Gly 
    1055                 1060                 1065             


Leu Ser  Trp Ala Gly Ser Trp  Ala Gly Cys Glu Leu  Pro Gln Ala 
    1070                 1075                 1080             


Gly Pro  Arg Pro Ala Leu Thr  Arg Ala Leu Leu Pro  Pro Ala Gly 
    1085                 1090                 1095             


Thr Gly  Gln Thr Leu Leu Leu  Gln Ala Leu Val Tyr  Asp Ala Ile 
    1100                 1105                 1110             


Lys Gly  Asn Gly Arg Lys Lys  Ser Pro Pro Ala Cys  Arg Asn Gln 
    1115                 1120                 1125             


Val Glu  Ala Glu Val Ile Val  His Ser Asp Phe Ser  Ala Ser Asn 
    1130                 1135                 1140             


Gly Asn  Pro Asp Leu His Leu  Gln Asp Leu Glu Pro  Glu Asp Pro 
    1145                 1150                 1155             


Leu Pro  Pro Glu Ala Pro Asp  Leu Ile Ser Gly Val  Gly Asp Pro 
    1160                 1165                 1170             


Gly Gln  Gly Ala Ala Trp Leu  Asp Arg Glu Leu Gly  Gly Cys Glu 
    1175                 1180                 1185             


Leu Ala  Ala Pro Gly Pro Asp  Arg Leu Thr Cys Leu  Pro Glu Ala 
    1190                 1195                 1200             


Ala Ser  Ala Ser Cys Ser Tyr  Pro Asp Leu Gln Pro  Gly Glu Val 
    1205                 1210                 1215             


Leu Glu  Glu Thr Pro Gly Asp  Ser Cys Gln Leu Lys  Ser Pro Cys 
    1220                 1225                 1230             


Pro Leu  Gly Ala Ser Pro Gly  Leu Pro Arg Ser Pro  Val Ser Ser 
    1235                 1240                 1245             


Ser Ala  
    1250 


<210>  4749
<211>  971
<212>  PRT
<213>  Homo sapiens

<400>  4749

Met Gly Val Ala Gly Arg Asn Arg Pro Gly Ala Ala Trp Ala Val Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Pro Pro Leu Leu Leu Leu Ala Gly Ala Val 
            20                  25                  30          


Pro Pro Gly Arg Gly Arg Ala Ala Gly Pro Gln Glu Asp Val Asp Glu 
        35                  40                  45              


Cys Ala Gln Gly Leu Asp Asp Cys His Ala Asp Ala Leu Cys Gln Asn 
    50                  55                  60                  


Thr Pro Thr Ser Tyr Lys Cys Ser Cys Lys Pro Gly Tyr Gln Gly Glu 
65                  70                  75                  80  


Gly Arg Gln Cys Glu Asp Ile Asp Glu Cys Gly Asn Glu Leu Asn Gly 
                85                  90                  95      


Gly Cys Val His Asp Cys Leu Asn Ile Pro Gly Asn Tyr Arg Cys Thr 
            100                 105                 110         


Cys Phe Asp Gly Phe Met Leu Ala His Asp Gly His Asn Cys Leu Asp 
        115                 120                 125             


Val Asp Glu Cys Leu Glu Asn Asn Gly Gly Cys Gln His Thr Cys Val 
    130                 135                 140                 


Asn Val Met Gly Ser Tyr Glu Cys Cys Cys Lys Glu Gly Phe Phe Leu 
145                 150                 155                 160 


Ser Asp Asn Gln His Thr Cys Ile His Arg Ser Glu Glu Gly Leu Ser 
                165                 170                 175     


Cys Met Asn Lys Asp His Gly Cys Ser His Ile Cys Lys Glu Ala Pro 
            180                 185                 190         


Arg Gly Ser Val Ala Cys Glu Cys Arg Pro Gly Phe Glu Leu Ala Lys 
        195                 200                 205             


Asn Gln Arg Asp Cys Ile Leu Thr Cys Asn His Gly Asn Gly Gly Cys 
    210                 215                 220                 


Gln His Ser Cys Asp Asp Thr Ala Asp Gly Pro Glu Cys Ser Cys His 
225                 230                 235                 240 


Pro Gln Tyr Lys Met His Thr Asp Gly Arg Ser Cys Leu Glu Arg Glu 
                245                 250                 255     


Asp Thr Val Leu Glu Val Thr Glu Ser Asn Thr Thr Ser Val Val Asp 
            260                 265                 270         


Gly Asp Lys Arg Val Lys Arg Arg Leu Leu Met Glu Thr Cys Ala Val 
        275                 280                 285             


Asn Asn Gly Gly Cys Asp Arg Thr Cys Lys Asp Thr Ser Thr Gly Val 
    290                 295                 300                 


His Cys Ser Cys Pro Val Gly Phe Thr Leu Gln Leu Asp Gly Lys Thr 
305                 310                 315                 320 


Cys Lys Asp Ile Asp Glu Cys Gln Thr Arg Asn Gly Gly Cys Asp His 
                325                 330                 335     


Phe Cys Lys Asn Ile Val Gly Ser Phe Asp Cys Gly Cys Lys Lys Gly 
            340                 345                 350         


Phe Lys Leu Leu Thr Asp Glu Lys Ser Cys Gln Asp Val Asp Glu Cys 
        355                 360                 365             


Ser Leu Asp Arg Thr Cys Asp His Ser Cys Ile Asn His Pro Gly Thr 
    370                 375                 380                 


Phe Ala Cys Ala Cys Asn Arg Gly Tyr Thr Leu Tyr Gly Phe Thr His 
385                 390                 395                 400 


Cys Gly Asp Thr Asn Glu Cys Ser Ile Asn Asn Gly Gly Cys Gln Gln 
                405                 410                 415     


Val Cys Val Asn Thr Val Gly Ser Tyr Glu Cys Gln Cys His Pro Gly 
            420                 425                 430         


Tyr Lys Leu His Trp Asn Lys Lys Asp Cys Val Glu Val Lys Gly Leu 
        435                 440                 445             


Leu Pro Thr Ser Val Ser Pro Arg Val Ser Leu His Cys Gly Lys Ser 
    450                 455                 460                 


Gly Gly Gly Asp Gly Cys Phe Leu Arg Cys His Ser Gly Ile His Leu 
465                 470                 475                 480 


Ser Ser Gly Leu Gln Gly Ala Tyr Ser Val Thr Cys Gly Ser Ser Ser 
                485                 490                 495     


Pro Leu Arg Asn Lys Gln Gln Lys Ser Asn Asp Ser Ala Phe Gly Asp 
            500                 505                 510         


Val Thr Thr Ile Arg Thr Ser Val Thr Phe Lys Leu Asn Glu Gly Lys 
        515                 520                 525             


Cys Ser Leu Lys Asn Ala Glu Leu Phe Pro Glu Gly Leu Arg Pro Ala 
    530                 535                 540                 


Leu Pro Glu Lys His Ser Ser Val Lys Glu Ser Phe Arg Tyr Val Asn 
545                 550                 555                 560 


Leu Thr Cys Ser Ser Gly Lys Gln Val Pro Gly Ala Pro Gly Arg Pro 
                565                 570                 575     


Ser Thr Pro Lys Glu Met Phe Ile Thr Val Glu Phe Glu Leu Glu Thr 
            580                 585                 590         


Asn Gln Lys Glu Val Thr Ala Ser Cys Asp Leu Ser Cys Ile Val Lys 
        595                 600                 605             


Arg Thr Glu Lys Arg Leu Arg Lys Ala Ile Arg Thr Leu Arg Lys Ala 
    610                 615                 620                 


Val His Arg Glu Gln Phe His Leu Gln Leu Ser Gly Met Asn Leu Asp 
625                 630                 635                 640 


Val Ala Lys Lys Pro Pro Arg Thr Ser Glu Arg Gln Ala Glu Ser Cys 
                645                 650                 655     


Gly Val Gly Gln Gly His Ala Glu Asn Gln Cys Gly Leu Cys Gln Pro 
            660                 665                 670         


Gly Glu Tyr Ser Ala Asp Gly Phe Ala Pro Cys Gln Leu Cys Ala Leu 
        675                 680                 685             


Gly Thr Phe Gln Pro Glu Ala Gly Arg Thr Ser Cys Phe Pro Cys Gly 
    690                 695                 700                 


Gly Gly Leu Ala Thr Lys His Gln Gly Ala Thr Ser Phe Gln Asp Cys 
705                 710                 715                 720 


Glu Thr Arg Val Gln Cys Ser Pro Gly His Phe Tyr Asn Thr Thr Thr 
                725                 730                 735     


His Arg Cys Ile Arg Cys Pro Val Gly Thr Tyr Gln Pro Glu Phe Gly 
            740                 745                 750         


Lys Asn Asn Cys Val Ser Cys Pro Gly Asn Thr Thr Thr Asp Phe Asp 
        755                 760                 765             


Gly Ser Thr Asn Ile Thr Gln Cys Lys Asn Arg Arg Cys Gly Gly Glu 
    770                 775                 780                 


Leu Gly Asp Phe Thr Gly Tyr Ile Glu Ser Pro Asn Tyr Pro Gly Asn 
785                 790                 795                 800 


Tyr Pro Ala Asn Thr Glu Cys Thr Trp Thr Ile Asn Pro Pro Pro Lys 
                805                 810                 815     


Arg Arg Ile Leu Ile Val Val Pro Glu Ile Phe Leu Pro Ile Glu Asp 
            820                 825                 830         


Asp Cys Gly Asp Tyr Leu Val Met Arg Lys Thr Ser Ser Ser Asn Ser 
        835                 840                 845             


Val Thr Thr Tyr Glu Thr Cys Gln Thr Tyr Glu Arg Pro Ile Ala Phe 
    850                 855                 860                 


Thr Ser Arg Ser Lys Lys Leu Trp Ile Gln Phe Lys Ser Asn Glu Gly 
865                 870                 875                 880 


Asn Ser Ala Arg Gly Phe Gln Val Pro Tyr Val Thr Tyr Asp Glu Asp 
                885                 890                 895     


Tyr Gln Glu Leu Ile Glu Asp Ile Val Arg Asp Gly Arg Leu Tyr Ala 
            900                 905                 910         


Ser Glu Asn His Gln Glu Ile Leu Lys Asp Lys Lys Leu Ile Lys Ala 
        915                 920                 925             


Leu Phe Asp Val Leu Ala His Pro Gln Asn Tyr Phe Lys Tyr Thr Ala 
    930                 935                 940                 


Gln Glu Ser Arg Glu Met Phe Pro Arg Ser Phe Ile Arg Leu Leu Arg 
945                 950                 955                 960 


Ser Lys Val Ser Arg Phe Leu Arg Pro Tyr Lys 
                965                 970     


<210>  4750
<211>  1114
<212>  PRT
<213>  Homo sapiens

<400>  4750

Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu Tyr Phe Ser 
            20                  25                  30          


Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Ala Ala Gly Thr 
        35                  40                  45              


Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Glu Glu Val Pro 
    50                  55                  60                  


Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr Arg Thr Arg Leu 
65                  70                  75                  80  


His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr Gly Leu Leu Tyr 
                85                  90                  95      


Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys Leu Ser Val Arg 
            100                 105                 110         


Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys Val Phe Leu Ser 
        115                 120                 125             


Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro Gly Cys Ala Arg 
    130                 135                 140                 


Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala Cys Ser Ser Leu 
145                 150                 155                 160 


Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile 
                165                 170                 175     


Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe Arg Leu Leu Pro 
            180                 185                 190         


Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu 
        195                 200                 205             


Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu Glu Val Ser 
    210                 215                 220                 


Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val 
225                 230                 235                 240 


Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val Val Met Val 
                245                 250                 255     


Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr Phe 
            260                 265                 270         


Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe Lys Arg Lys 
        275                 280                 285             


Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala Asp Val Val 
    290                 295                 300                 


Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu Pro 
305                 310                 315                 320 


Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu His Trp Pro Asn 
                325                 330                 335     


Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala Thr Val His 
            340                 345                 350         


Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser Glu Asn Arg 
        355                 360                 365             


Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly Pro 
    370                 375                 380                 


Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val Leu Pro Val 
385                 390                 395                 400 


Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val Ser Arg Arg Ala 
                405                 410                 415     


Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Ala 
            420                 425                 430         


Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly Ala Asn 
        435                 440                 445             


Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser Gly Ile 
    450                 455                 460                 


Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu 
465                 470                 475                 480 


Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg Gln Ala 
                485                 490                 495     


Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala Glu Glu 
            500                 505                 510         


Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg Leu Glu Cys 
        515                 520                 525             


Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg 
    530                 535                 540                 


Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro 
545                 550                 555                 560 


Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val Glu Thr Gln 
                565                 570                 575     


Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser Ile Val Gly 
            580                 585                 590         


Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly Tyr Gly Thr 
        595                 600                 605             


Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu Pro Glu Asp 
    610                 615                 620                 


Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Ala Ala 
625                 630                 635                 640 


Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys 
                645                 650                 655     


Ile His Cys Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala 
            660                 665                 670         


Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser 
        675                 680                 685             


Ser Ser Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val 
    690                 695                 700                 


Ser Val Asp Ala Phe Lys Ile Leu Glu Asp Pro Lys Trp Glu Phe Pro 
705                 710                 715                 720 


Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly 
                725                 730                 735     


Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg Ala Gly Tyr 
            740                 745                 750         


Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Pro Ser Glu 
        755                 760                 765             


Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys Gln Val Asn His 
    770                 775                 780                 


Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu 
785                 790                 795                 800 


Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu 
                805                 810                 815     


Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser Gly Gly Ser 
            820                 825                 830         


Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Ala Leu Thr Met 
        835                 840                 845             


Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Gln Gly Met Gln Tyr 
    850                 855                 860                 


Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn Ile 
865                 870                 875                 880 


Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser 
                885                 890                 895     


Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln Gly Arg 
            900                 905                 910         


Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr 
        915                 920                 925             


Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile 
    930                 935                 940                 


Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu 
945                 950                 955                 960 


Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys 
                965                 970                 975     


Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu Pro 
            980                 985                 990         


Asp Lys Arg Pro Val Phe Ala Asp  Ile Ser Lys Asp Leu  Glu Lys Met 
        995                 1000                 1005             


Met Val  Lys Arg Arg Asp Tyr  Leu Asp Leu Ala Ala  Ser Thr Pro 
    1010                 1015                 1020             


Ser Asp  Ser Leu Ile Tyr Asp  Asp Gly Leu Ser Glu  Glu Glu Thr 
    1025                 1030                 1035             


Pro Leu  Val Asp Cys Asn Asn  Ala Pro Leu Pro Arg  Ala Leu Pro 
    1040                 1045                 1050             


Ser Thr  Trp Ile Glu Asn Lys  Leu Tyr Gly Met Ser  Asp Pro Asn 
    1055                 1060                 1065             


Trp Pro  Gly Glu Ser Pro Val  Pro Leu Thr Arg Ala  Asp Gly Thr 
    1070                 1075                 1080             


Asn Thr  Gly Phe Pro Arg Tyr  Pro Asn Asp Ser Val  Tyr Ala Asn 
    1085                 1090                 1095             


Trp Met  Leu Ser Pro Ser Ala  Ala Lys Leu Met Asp  Thr Phe Asp 
    1100                 1105                 1110             


Ser 
    


<210>  4751
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  4751

Met Ala Ser Lys Val Ser Cys Leu Tyr Val Leu Thr Val Val Cys Trp 
1               5                   10                  15      


Ala Ser Ala Leu Trp Tyr Leu Ser Ile Thr Arg Pro Thr Ser Ser Tyr 
            20                  25                  30          


Thr Gly Ser Lys Pro Phe Ser His Leu Thr Val Ala Arg Lys Asn Phe 
        35                  40                  45              


Thr Phe Gly Asn Ile Arg Thr Arg Pro Ile Asn Pro His Ser Phe Glu 
    50                  55                  60                  


Phe Leu Ile Asn Glu Pro Asn Lys Cys Glu Lys Asn Ile Pro Phe Leu 
65                  70                  75                  80  


Val Ile Leu Ile Ser Thr Thr His Lys Glu Phe Asp Ala Arg Gln Ala 
                85                  90                  95      


Ile Arg Glu Thr Trp Gly Asp Glu Asn Asn Phe Lys Gly Ile Lys Ile 
            100                 105                 110         


Ala Thr Leu Phe Leu Leu Gly Lys Asn Ala Asp Pro Val Leu Asn Gln 
        115                 120                 125             


Met Val Glu Gln Glu Ser Gln Ile Phe His Asp Ile Ile Val Glu Asp 
    130                 135                 140                 


Phe Ile Asp Ser Tyr His Asn Leu Thr Leu Lys Thr Leu Met Gly Met 
145                 150                 155                 160 


Arg Trp Val Ala Thr Phe Cys Ser Lys Ala Lys Tyr Val Met Lys Thr 
                165                 170                 175     


Asp Ser Asp Ile Phe Val Asn Met Asp Asn Leu Ile Tyr Lys Leu Leu 
            180                 185                 190         


Lys Pro Ser Thr Lys Pro Arg Arg Arg Tyr Phe Thr Gly Tyr Val Ile 
        195                 200                 205             


Asn Gly Gly Pro Ile Arg Asp Val Arg Ser Lys Trp Tyr Met Pro Arg 
    210                 215                 220                 


Asp Leu Tyr Pro Asp Ser Asn Tyr Pro Pro Phe Cys Ser Gly Thr Gly 
225                 230                 235                 240 


Tyr Ile Phe Ser Ala Asp Val Ala Glu Leu Ile Tyr Lys Thr Ser Leu 
                245                 250                 255     


His Thr Arg Leu Leu His Leu Glu Asp Val Tyr Val Gly Leu Cys Leu 
            260                 265                 270         


Arg Lys Leu Gly Ile His Pro Phe Gln Asn Ser Gly Phe Asn His Trp 
        275                 280                 285             


Lys Met Ala Tyr Ser Leu Cys Arg Tyr Arg Arg Val Ile Thr Val His 
    290                 295                 300                 


Gln Ile Ser Pro Glu Glu Met His Arg Ile Trp Asn Asp Met Ser Ser 
305                 310                 315                 320 


Lys Lys His Leu Arg Cys 
                325     


<210>  4752
<211>  1168
<212>  PRT
<213>  Homo sapiens

<400>  4752

Met Ser Trp Phe Ser Gly Leu Leu Val Pro Lys Val Asp Glu Arg Lys 
1               5                   10                  15      


Thr Ala Trp Gly Glu Arg Asn Gly Gln Lys Arg Ser Arg Arg Arg Gly 
            20                  25                  30          


Thr Arg Ala Gly Gly Phe Cys Thr Pro Arg Tyr Met Ser Cys Leu Arg 
        35                  40                  45              


Asp Ala Glu Pro Pro Ser Pro Thr Pro Ala Gly Pro Pro Arg Cys Pro 
    50                  55                  60                  


Trp Gln Asp Asp Ala Phe Ile Arg Arg Gly Gly Pro Gly Lys Gly Lys 
65                  70                  75                  80  


Glu Leu Gly Leu Arg Ala Val Ala Leu Gly Phe Glu Asp Thr Glu Val 
                85                  90                  95      


Thr Thr Thr Ala Gly Gly Thr Ala Glu Val Ala Pro Asp Ala Val Pro 
            100                 105                 110         


Arg Ser Gly Arg Ser Cys Trp Arg Arg Leu Val Gln Val Phe Gln Ser 
        115                 120                 125             


Lys Gln Phe Arg Ser Ala Lys Leu Glu Arg Leu Tyr Gln Arg Tyr Phe 
    130                 135                 140                 


Phe Gln Met Asn Gln Ser Ser Leu Thr Leu Leu Met Ala Val Leu Val 
145                 150                 155                 160 


Leu Leu Thr Ala Val Leu Leu Ala Phe His Ala Ala Pro Ala Arg Pro 
                165                 170                 175     


Gln Pro Ala Tyr Val Ala Leu Leu Ala Cys Ala Ala Ala Leu Phe Val 
            180                 185                 190         


Gly Leu Met Val Val Cys Asn Arg His Ser Phe Arg Gln Asp Ser Met 
        195                 200                 205             


Trp Val Val Ser Tyr Val Val Leu Gly Ile Leu Ala Ala Val Gln Val 
    210                 215                 220                 


Gly Gly Ala Leu Ala Ala Asp Pro Arg Ser Pro Ser Ala Gly Leu Trp 
225                 230                 235                 240 


Cys Pro Val Phe Phe Val Tyr Ile Ala Tyr Thr Leu Leu Pro Ile Arg 
                245                 250                 255     


Met Arg Ala Ala Val Leu Ser Gly Leu Gly Leu Ser Thr Leu His Leu 
            260                 265                 270         


Ile Leu Ala Trp Gln Leu Asn Arg Gly Asp Ala Phe Leu Trp Lys Gln 
        275                 280                 285             


Leu Gly Ala Asn Val Leu Leu Phe Leu Cys Thr Asn Val Ile Gly Ile 
    290                 295                 300                 


Cys Thr His Tyr Pro Ala Glu Val Ser Gln Arg Gln Ala Phe Gln Glu 
305                 310                 315                 320 


Thr Arg Gly Tyr Ile Gln Ala Arg Leu His Leu Gln His Glu Asn Arg 
                325                 330                 335     


Gln Gln Glu Arg Leu Leu Leu Ser Val Leu Pro Gln His Val Ala Met 
            340                 345                 350         


Glu Met Lys Glu Asp Ile Asn Thr Lys Lys Glu Asp Met Met Phe His 
        355                 360                 365             


Lys Ile Tyr Ile Gln Lys His Asp Asn Val Ser Ile Leu Phe Ala Asp 
    370                 375                 380                 


Ile Glu Gly Phe Thr Ser Leu Ala Ser Gln Cys Thr Ala Gln Glu Leu 
385                 390                 395                 400 


Val Met Thr Leu Asn Glu Leu Phe Ala Arg Phe Asp Lys Leu Ala Ala 
                405                 410                 415     


Glu Asn His Cys Leu Arg Ile Lys Ile Leu Gly Asp Cys Tyr Tyr Cys 
            420                 425                 430         


Val Ser Gly Leu Pro Glu Ala Arg Ala Asp His Ala His Cys Cys Val 
        435                 440                 445             


Glu Met Gly Val Asp Met Ile Glu Ala Ile Ser Leu Val Arg Glu Val 
    450                 455                 460                 


Thr Gly Val Asn Val Asn Met Arg Val Gly Ile His Ser Gly Arg Val 
465                 470                 475                 480 


His Cys Gly Val Leu Gly Leu Arg Lys Trp Gln Phe Asp Val Trp Ser 
                485                 490                 495     


Asn Asp Val Thr Leu Ala Asn His Met Glu Ala Gly Gly Arg Ala Gly 
            500                 505                 510         


Arg Ile His Ile Thr Arg Ala Thr Leu Gln Tyr Leu Asn Gly Asp Tyr 
        515                 520                 525             


Glu Val Glu Pro Gly Arg Gly Gly Glu Arg Asn Ala Tyr Leu Lys Glu 
    530                 535                 540                 


Gln His Ile Glu Thr Phe Leu Ile Leu Gly Ala Ser Gln Lys Arg Lys 
545                 550                 555                 560 


Glu Glu Lys Ala Met Leu Ala Lys Leu Gln Arg Thr Arg Ala Asn Ser 
                565                 570                 575     


Met Glu Gly Leu Met Pro Arg Trp Val Pro Asp Arg Ala Phe Ser Arg 
            580                 585                 590         


Thr Lys Asp Ser Lys Ala Phe Arg Gln Met Gly Ile Asp Asp Ser Ser 
        595                 600                 605             


Lys Asp Asn Arg Gly Thr Gln Asp Ala Leu Asn Pro Glu Asp Glu Val 
    610                 615                 620                 


Asp Glu Phe Leu Ser Arg Ala Ile Asp Ala Arg Ser Ile Asp Gln Leu 
625                 630                 635                 640 


Arg Lys Asp His Val Arg Arg Phe Leu Leu Thr Phe Gln Arg Glu Asp 
                645                 650                 655     


Leu Glu Lys Lys Tyr Ser Arg Lys Val Asp Pro Arg Phe Gly Ala Tyr 
            660                 665                 670         


Val Ala Cys Ala Leu Leu Val Phe Cys Phe Ile Cys Phe Ile Gln Leu 
        675                 680                 685             


Leu Ile Phe Pro His Ser Thr Leu Met Leu Gly Ile Tyr Ala Ser Ile 
    690                 695                 700                 


Phe Leu Leu Leu Leu Ile Thr Val Leu Ile Cys Ala Val Tyr Ser Cys 
705                 710                 715                 720 


Gly Ser Leu Phe Pro Lys Ala Leu Gln Arg Leu Ser Arg Ser Ile Val 
                725                 730                 735     


Arg Ser Arg Ala His Ser Thr Ala Val Gly Ile Phe Ser Val Leu Leu 
            740                 745                 750         


Val Phe Thr Ser Ala Ile Ala Asn Met Phe Thr Cys Asn His Thr Pro 
        755                 760                 765             


Ile Arg Ser Cys Ala Ala Arg Met Leu Asn Leu Thr Pro Ala Asp Ile 
    770                 775                 780                 


Thr Ala Cys His Leu Gln Gln Leu Asn Tyr Ser Leu Gly Leu Asp Ala 
785                 790                 795                 800 


Pro Leu Cys Glu Gly Thr Met Pro Thr Cys Ser Phe Pro Glu Tyr Phe 
                805                 810                 815     


Ile Gly Asn Met Leu Leu Ser Leu Leu Ala Ser Ser Val Phe Leu His 
            820                 825                 830         


Ile Ser Ser Ile Gly Lys Leu Ala Met Ile Phe Val Leu Gly Leu Ile 
        835                 840                 845             


Tyr Leu Val Leu Leu Leu Leu Gly Pro Pro Ala Thr Ile Phe Asp Asn 
    850                 855                 860                 


Tyr Asp Leu Leu Leu Gly Val His Gly Leu Ala Ser Ser Asn Glu Thr 
865                 870                 875                 880 


Phe Asp Gly Leu Asp Cys Pro Ala Ala Gly Arg Val Ala Leu Lys Tyr 
                885                 890                 895     


Met Thr Pro Val Ile Leu Leu Val Phe Ala Leu Ala Leu Tyr Leu His 
            900                 905                 910         


Ala Gln Gln Val Glu Ser Thr Ala Arg Leu Asp Phe Leu Trp Lys Leu 
        915                 920                 925             


Gln Ala Thr Gly Glu Lys Glu Glu Met Glu Glu Leu Gln Ala Tyr Asn 
    930                 935                 940                 


Arg Arg Leu Leu His Asn Ile Leu Pro Lys Asp Val Ala Ala His Phe 
945                 950                 955                 960 


Leu Ala Arg Glu Arg Arg Asn Asp Glu Leu Tyr Tyr Gln Ser Cys Glu 
                965                 970                 975     


Cys Val Ala Val Met Phe Ala Ser Ile Ala Asn Phe Ser Glu Phe Tyr 
            980                 985                 990         


Val Glu Leu Glu Ala Asn Asn Glu  Gly Val Glu Cys Leu  Arg Leu Leu 
        995                 1000                 1005             


Asn Glu  Ile Ile Ala Asp Phe  Asp Glu Ile Ile Ser  Glu Glu Arg 
    1010                 1015                 1020             


Phe Arg  Gln Leu Glu Lys Ile  Lys Thr Ile Gly Ser  Thr Tyr Met 
    1025                 1030                 1035             


Ala Ala  Ser Gly Leu Asn Ala  Ser Thr Tyr Asp Gln  Val Gly Arg 
    1040                 1045                 1050             


Ser His  Ile Thr Ala Leu Ala  Asp Tyr Ala Met Arg  Leu Met Glu 
    1055                 1060                 1065             


Gln Met  Lys His Ile Asn Glu  His Ser Phe Asn Asn  Phe Gln Met 
    1070                 1075                 1080             


Lys Ile  Gly Leu Asn Met Gly  Pro Val Val Ala Gly  Val Ile Gly 
    1085                 1090                 1095             


Ala Arg  Lys Pro Gln Tyr Asp  Ile Trp Gly Asn Thr  Val Asn Val 
    1100                 1105                 1110             


Ser Ser  Arg Met Asp Ser Thr  Gly Val Pro Asp Arg  Ile Gln Val 
    1115                 1120                 1125             


Thr Thr  Asp Leu Tyr Gln Val  Leu Ala Ala Lys Gly  Tyr Gln Leu 
    1130                 1135                 1140             


Glu Cys  Arg Gly Val Val Lys  Val Lys Gly Lys Gly  Glu Met Thr 
    1145                 1150                 1155             


Thr Tyr  Phe Leu Asn Gly Gly  Pro Ser Ser 
    1160                 1165             


<210>  4753
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  4753

Met Ala Ser Thr Gly Leu Glu Leu Leu Gly Met Thr Leu Ala Val Leu 
1               5                   10                  15      


Gly Trp Leu Gly Thr Leu Val Ser Cys Ala Leu Pro Leu Trp Lys Val 
            20                  25                  30          


Thr Ala Phe Ile Gly Asn Ser Ile Val Val Ala Gln Val Val Trp Glu 
        35                  40                  45              


Gly Leu Trp Met Ser Cys Val Val Gln Ser Thr Gly Gln Met Gln Cys 
    50                  55                  60                  


Lys Val Tyr Asp Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala 
65                  70                  75                  80  


Arg Ala Leu Cys Val Ile Ala Leu Leu Leu Ala Leu Leu Gly Leu Leu 
                85                  90                  95      


Val Ala Ile Thr Gly Ala Gln Cys Thr Thr Cys Val Glu Asp Glu Gly 
            100                 105                 110         


Ala Lys Ala Arg Ile Val Leu Thr Ala Gly Val Ile Leu Leu Leu Ala 
        115                 120                 125             


Gly Ile Leu Val Leu Ile Pro Val Cys Trp Thr Ala His Ala Ile Ile 
    130                 135                 140                 


Gln Asp Phe Tyr Asn Pro Leu Val Ala Glu Ala Leu Lys Arg Glu Leu 
145                 150                 155                 160 


Gly Ala Ser Leu Tyr Leu Gly Trp Ala Ala Ala Ala Leu Leu Met Leu 
                165                 170                 175     


Gly Gly Gly Leu Leu Cys Cys Thr Cys Pro Pro Pro Gln Val Glu Arg 
            180                 185                 190         


Pro Arg Gly Pro Arg Leu Gly Tyr Ser Ile Pro Ser Arg Ser Gly Ala 
        195                 200                 205             


Ser Gly Leu Asp Lys Arg Asp Tyr Val 
    210                 215         


<210>  4754
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  4754

Met Gly Lys Ile Thr Phe Tyr Glu Asp Arg Ala Phe Gln Gly Arg Ser 
1               5                   10                  15      


Tyr Glu Thr Thr Thr Asp Cys Pro Asn Leu Gln Pro Tyr Phe Ser Arg 
            20                  25                  30          


Cys Asn Ser Ile Arg Val Glu Ser Gly Cys Trp Met Leu Tyr Glu Arg 
        35                  40                  45              


Pro Asn Tyr Gln Gly Gln Gln Tyr Leu Leu Arg Arg Gly Glu Tyr Pro 
    50                  55                  60                  


Asp Tyr Gln Gln Trp Met Gly Leu Ser Asp Ser Ile Arg Ser Cys Cys 
65                  70                  75                  80  


Leu Ile Pro Gln Thr Val Ser His Arg Leu Arg Leu Tyr Glu Arg Glu 
                85                  90                  95      


Asp His Lys Gly Leu Met Met Glu Leu Ser Glu Asp Cys Pro Ser Ile 
            100                 105                 110         


Gln Asp Arg Phe His Leu Ser Glu Ile Arg Ser Leu His Val Leu Glu 
        115                 120                 125             


Gly Cys Trp Val Leu Tyr Glu Leu Pro Asn Tyr Arg Gly Arg Gln Tyr 
    130                 135                 140                 


Leu Leu Arg Pro Gln Glu Tyr Arg Arg Cys Gln Asp Trp Gly Ala Met 
145                 150                 155                 160 


Asp Ala Lys Ala Gly Ser Leu Arg Arg Val Val Asp Leu Tyr 
                165                 170                 


<210>  4755
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  4755

Met Ala Ala Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Thr Val Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp His Ala Met Leu Gln Ala His Arg Ala His Gln 
        35                  40                  45              


Leu Ala Ile Asp Thr Tyr Gln Glu Phe Glu Glu Thr Tyr Ile Pro Lys 
    50                  55                  60                  


Asp Gln Lys Tyr Ser Phe Leu His Asp Ser Gln Thr Ser Phe Cys Phe 
65                  70                  75                  80  


Ser Asp Ser Ile Pro Thr Pro Ser Asn Met Glu Glu Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Glu Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Arg Phe Leu Arg Ser Met Phe Ala Asn Asn Leu Val 
        115                 120                 125             


Tyr Asp Thr Ser Asp Ser Asp Asp Tyr His Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Arg Arg 
145                 150                 155                 160 


Thr Gly Gln Ile Leu Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser 
                165                 170                 175     


His Asn His Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe 
            180                 185                 190         


Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Met Val Gln Cys 
        195                 200                 205             


Arg Ser Val Glu Gly Ser Cys Gly Phe 
    210                 215         


<210>  4756
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  4756

Met Ala Leu Gly Gln Lys Leu Phe Ile Thr Met Ser Arg Gly Ala Gly 
1               5                   10                  15      


Arg Leu Gln Gly Thr Leu Trp Ala Leu Val Phe Leu Gly Ile Leu Val 
            20                  25                  30          


Gly Met Val Val Pro Ser Pro Ala Gly Thr Arg Ala Asn Asn Thr Leu 
        35                  40                  45              


Leu Asp Ser Arg Gly Trp Gly Thr Leu Leu Ser Arg Ser Arg Ala Gly 
    50                  55                  60                  


Leu Ala Gly Glu Ile Ala Gly Val Asn Trp Glu Ser Gly Tyr Leu Val 
65                  70                  75                  80  


Gly Ile Lys Arg Gln Arg Arg Leu Tyr Cys Asn Val Gly Ile Gly Phe 
                85                  90                  95      


His Leu Gln Val Leu Pro Asp Gly Arg Ile Ser Gly Thr His Glu Glu 
            100                 105                 110         


Asn Pro Tyr Ser Leu Leu Glu Ile Ser Thr Val Glu Arg Gly Val Val 
        115                 120                 125             


Ser Leu Phe Gly Val Arg Ser Ala Leu Phe Val Ala Met Asn Ser Lys 
    130                 135                 140                 


Gly Arg Leu Tyr Ala Thr Pro Ser Phe Gln Glu Glu Cys Lys Phe Arg 
145                 150                 155                 160 


Glu Thr Leu Leu Pro Asn Asn Tyr Asn Ala Tyr Glu Ser Asp Leu Tyr 
                165                 170                 175     


Gln Gly Thr Tyr Ile Ala Leu Ser Lys Tyr Gly Arg Val Lys Arg Gly 
            180                 185                 190         


Ser Lys Val Ser Pro Ile Met Thr Val Thr His Phe Leu Pro Arg Ile 
        195                 200                 205             


<210>  4757
<211>  2005
<212>  PRT
<213>  Homo sapiens

<400>  4757

Met Ala Gln Ser Val Leu Val Pro Pro Gly Pro Asp Ser Phe Arg Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Arg Pro Lys Gln Glu Arg Lys Asp Glu Asp Asp Glu Asn 
        35                  40                  45              


Gly Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Ser Leu Pro Phe 
    50                  55                  60                  


Ile Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Val Pro Leu Glu Asp 
65                  70                  75                  80  


Leu Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys 
                85                  90                  95      


Gly Lys Ala Ile Ser Arg Phe Ser Ala Thr Pro Ala Leu Tyr Ile Leu 
            100                 105                 110         


Thr Pro Phe Asn Pro Ile Arg Lys Leu Ala Ile Lys Ile Leu Val His 
        115                 120                 125             


Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val 
    130                 135                 140                 


Phe Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr 
145                 150                 155                 160 


Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala 
                165                 170                 175     


Arg Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn 
            180                 185                 190         


Trp Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val 
        195                 200                 205             


Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala 
    210                 215                 220                 


Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala 
225                 230                 235                 240 


Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val 
                245                 250                 255     


Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly 
            260                 265                 270         


Asn Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Asp Asn Ser Ser Phe 
        275                 280                 285             


Glu Ile Asn Ile Thr Ser Phe Phe Asn Asn Ser Leu Asp Gly Asn Gly 
    290                 295                 300                 


Thr Thr Phe Asn Arg Thr Val Ser Ile Phe Asn Trp Asp Glu Tyr Ile 
305                 310                 315                 320 


Glu Asp Lys Ser His Phe Tyr Phe Leu Glu Gly Gln Asn Asp Ala Leu 
                325                 330                 335     


Leu Cys Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile 
            340                 345                 350         


Cys Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp 
        355                 360                 365             


Thr Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp 
    370                 375                 380                 


Phe Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr 
385                 390                 395                 400 


Tyr Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu 
                405                 410                 415     


Ile Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn 
            420                 425                 430         


Gln Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln 
        435                 440                 445             


Met Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Ala Ala 
    450                 455                 460                 


Ala Ala Ala Ser Ala Glu Ser Arg Asp Phe Ser Gly Ala Gly Gly Ile 
465                 470                 475                 480 


Gly Val Phe Ser Glu Ser Ser Ser Val Ala Ser Lys Leu Ser Ser Lys 
                485                 490                 495     


Ser Glu Lys Glu Leu Lys Asn Arg Arg Lys Lys Lys Lys Gln Lys Glu 
            500                 505                 510         


Gln Ser Gly Glu Glu Glu Lys Asn Asp Arg Val Arg Lys Ser Glu Ser 
        515                 520                 525             


Glu Asp Ser Ile Arg Arg Lys Gly Phe Arg Phe Ser Leu Glu Gly Ser 
    530                 535                 540                 


Arg Leu Thr Tyr Glu Lys Arg Phe Ser Ser Pro His Gln Ser Leu Leu 
545                 550                 555                 560 


Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Ala Ser 
                565                 570                 575     


Leu Phe Ser Phe Arg Gly Arg Ala Lys Asp Ile Gly Ser Glu Asn Asp 
            580                 585                 590         


Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Asn Asp Ser Arg Arg 
        595                 600                 605             


Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg His Ser Asn 
    610                 615                 620                 


Val Ser Gln Ala Ser Arg Ala Ser Arg Val Leu Pro Ile Leu Pro Met 
625                 630                 635                 640 


Asn Gly Lys Met His Ser Ala Val Asp Cys Asn Gly Val Val Ser Leu 
                645                 650                 655     


Val Gly Gly Pro Ser Thr Leu Thr Ser Ala Gly Gln Leu Leu Pro Glu 
            660                 665                 670         


Gly Thr Thr Thr Glu Thr Glu Ile Arg Lys Arg Arg Ser Ser Ser Tyr 
        675                 680                 685             


His Val Ser Met Asp Leu Leu Glu Asp Pro Thr Ser Arg Gln Arg Ala 
    690                 695                 700                 


Met Ser Ile Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu Glu 
705                 710                 715                 720 


Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Lys Phe Ala Asn Met Cys 
                725                 730                 735     


Leu Ile Trp Asp Cys Cys Lys Pro Trp Leu Lys Val Lys His Leu Val 
            740                 745                 750         


Asn Leu Val Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
        755                 760                 765             


Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met Thr 
    770                 775                 780                 


Glu Gln Phe Ser Ser Val Leu Ser Val Gly Asn Leu Val Phe Thr Gly 
785                 790                 795                 800 


Ile Phe Thr Ala Glu Met Phe Leu Lys Ile Ile Ala Met Asp Pro Tyr 
                805                 810                 815     


Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Phe Ile Val Ser 
            820                 825                 830         


Leu Ser Leu Met Glu Leu Gly Leu Ala Asn Val Glu Gly Leu Ser Val 
        835                 840                 845             


Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
    850                 855                 860                 


Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
865                 870                 875                 880 


Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 
                885                 890                 895     


Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys 
            900                 905                 910         


Lys Ile Ser Asn Asp Cys Glu Leu Pro Arg Trp His Met His Asp Phe 
        915                 920                 925             


Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile 
    930                 935                 940                 


Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys Leu 
945                 950                 955                 960 


Thr Val Phe Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn 
                965                 970                 975     


Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Ala 
            980                 985                 990         


Ala Thr Asp Asp Asp Asn Glu Met  Asn Asn Leu Gln Ile  Ala Val Gly 
        995                 1000                 1005             


Arg Met  Gln Lys Gly Ile Asp  Phe Val Lys Arg Lys  Ile Arg Glu 
    1010                 1015                 1020             


Phe Ile  Gln Lys Ala Phe Val  Arg Lys Gln Lys Ala  Leu Asp Glu 
    1025                 1030                 1035             


Ile Lys  Pro Leu Glu Asp Leu  Asn Asn Lys Lys Asp  Ser Cys Ile 
    1040                 1045                 1050             


Ser Asn  His Thr Thr Ile Glu  Ile Gly Lys Asp Leu  Asn Tyr Leu 
    1055                 1060                 1065             


Lys Asp  Gly Asn Gly Thr Thr  Ser Gly Ile Gly Ser  Ser Val Glu 
    1070                 1075                 1080             


Lys Tyr  Val Val Asp Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn 
    1085                 1090                 1095             


Pro Ser  Leu Thr Val Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp 
    1100                 1105                 1110             


Phe Glu  Asn Leu Asn Thr Glu  Glu Phe Ser Ser Glu  Ser Asp Met 
    1115                 1120                 1125             


Glu Glu  Ser Lys Glu Lys Leu  Asn Ala Thr Ser Ser  Ser Glu Gly 
    1130                 1135                 1140             


Ser Thr  Val Asp Ile Gly Ala  Pro Ala Glu Gly Glu  Gln Pro Glu 
    1145                 1150                 1155             


Val Glu  Pro Glu Glu Ser Leu  Glu Pro Glu Ala Cys  Phe Thr Glu 
    1160                 1165                 1170             


Asp Cys  Val Arg Lys Phe Lys  Cys Cys Gln Ile Ser  Ile Glu Glu 
    1175                 1180                 1185             


Gly Lys  Gly Lys Leu Trp Trp  Asn Leu Arg Lys Thr  Cys Tyr Lys 
    1190                 1195                 1200             


Ile Val  Glu His Asn Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile 
    1205                 1210                 1215             


Leu Leu  Ser Ser Gly Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Glu 
    1220                 1225                 1230             


Gln Arg  Lys Thr Ile Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val 
    1235                 1240                 1245             


Phe Thr  Tyr Ile Phe Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala 
    1250                 1255                 1260             


Tyr Gly  Phe Gln Val Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp 
    1265                 1270                 1275             


Phe Leu  Ile Val Asp Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala 
    1280                 1285                 1290             


Leu Gly  Tyr Ser Glu Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu 
    1295                 1300                 1305             


Arg Ala  Leu Arg Pro Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met 
    1310                 1315                 1320             


Arg Val  Val Val Asn Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met 
    1325                 1330                 1335             


Asn Val  Leu Leu Val Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile 
    1340                 1345                 1350             


Met Gly  Val Asn Leu Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn 
    1355                 1360                 1365             


Tyr Thr  Thr Gly Glu Met Phe  Asp Val Ser Val Val  Asn Asn Tyr 
    1370                 1375                 1380             


Ser Glu  Cys Lys Ala Leu Ile  Glu Ser Asn Gln Thr  Ala Arg Trp 
    1385                 1390                 1395             


Lys Asn  Val Lys Val Asn Phe  Asp Asn Val Gly Leu  Gly Tyr Leu 
    1400                 1405                 1410             


Ser Leu  Leu Gln Val Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met 
    1415                 1420                 1425             


Tyr Ala  Ala Val Asp Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr 
    1430                 1435                 1440             


Glu Asp  Asn Leu Tyr Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile 
    1445                 1450                 1455             


Phe Gly  Ser Phe Phe Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile 
    1460                 1465                 1470             


Asp Asn  Phe Asn Gln Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile 
    1475                 1480                 1485             


Phe Met  Thr Glu Glu Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys 
    1490                 1495                 1500             


Leu Gly  Ser Lys Lys Pro Gln  Lys Pro Ile Pro Arg  Pro Ala Asn 
    1505                 1510                 1515             


Lys Phe  Gln Gly Met Val Phe  Asp Phe Val Thr Lys  Gln Val Phe 
    1520                 1525                 1530             


Asp Ile  Ser Ile Met Ile Leu  Ile Cys Leu Asn Met  Val Thr Met 
    1535                 1540                 1545             


Met Val  Glu Thr Asp Asp Gln  Ser Gln Glu Met Thr  Asn Ile Leu 
    1550                 1555                 1560             


Tyr Trp  Ile Asn Leu Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys 
    1565                 1570                 1575             


Val Leu  Lys Leu Ile Ser Leu  Arg Tyr Tyr Tyr Phe  Thr Ile Gly 
    1580                 1585                 1590             


Trp Asn  Ile Phe Asp Phe Val  Val Val Ile Leu Ser  Ile Val Gly 
    1595                 1600                 1605             


Met Phe  Leu Ala Glu Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr 
    1610                 1615                 1620             


Leu Phe  Arg Val Ile Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg 
    1625                 1630                 1635             


Leu Ile  Lys Gly Ala Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu 
    1640                 1645                 1650             


Met Met  Ser Leu Pro Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe 
    1655                 1660                 1665             


Leu Val  Met Phe Ile Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala 
    1670                 1675                 1680             


Tyr Val  Lys Arg Glu Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu 
    1685                 1690                 1695             


Thr Phe  Gly Asn Ser Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser 
    1700                 1705                 1710             


Ala Gly  Trp Asp Gly Leu Leu  Ala Pro Ile Leu Asn  Ser Gly Pro 
    1715                 1720                 1725             


Pro Asp  Cys Asp Pro Asp Lys  Asp His Pro Gly Ser  Ser Val Lys 
    1730                 1735                 1740             


Gly Asp  Cys Gly Asn Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser 
    1745                 1750                 1755             


Tyr Ile  Ile Ile Ser Phe Leu  Val Val Val Asn Met  Tyr Ile Ala 
    1760                 1765                 1770             


Val Ile  Leu Glu Asn Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu 
    1775                 1780                 1785             


Pro Leu  Ser Glu Asp Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu 
    1790                 1795                 1800             


Lys Phe  Asp Pro Asp Ala Thr  Gln Phe Ile Glu Phe  Ala Lys Leu 
    1805                 1810                 1815             


Ser Asp  Phe Ala Asp Ala Leu  Asp Pro Pro Leu Leu  Ile Ala Lys 
    1820                 1825                 1830             


Pro Asn  Lys Val Gln Leu Ile  Ala Met Asp Leu Pro  Met Val Ser 
    1835                 1840                 1845             


Gly Asp  Arg Ile His Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys 
    1850                 1855                 1860             


Arg Val  Leu Gly Glu Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln 
    1865                 1870                 1875             


Met Glu  Glu Arg Phe Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr 
    1880                 1885                 1890             


Glu Pro  Ile Thr Thr Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser 
    1895                 1900                 1905             


Ala Ile  Ile Ile Gln Arg Ala  Tyr Arg Arg Tyr Leu  Leu Lys Gln 
    1910                 1915                 1920             


Lys Val  Lys Lys Val Ser Ser  Ile Tyr Lys Lys Asp  Lys Gly Lys 
    1925                 1930                 1935             


Glu Cys  Asp Gly Thr Pro Ile  Lys Glu Asp Thr Leu  Ile Asp Lys 
    1940                 1945                 1950             


Leu Asn  Glu Asn Ser Thr Pro  Glu Lys Thr Asp Met  Thr Pro Ser 
    1955                 1960                 1965             


Thr Thr  Ser Pro Pro Ser Tyr  Asp Ser Val Thr Lys  Pro Glu Lys 
    1970                 1975                 1980             


Glu Lys  Phe Glu Lys Asp Lys  Ser Glu Lys Glu Asp  Lys Gly Lys 
    1985                 1990                 1995             


Asp Ile  Arg Glu Ser Lys Lys  
    2000                 2005 


<210>  4758
<211>  565
<212>  PRT
<213>  Homo sapiens

<400>  4758

Met Glu Asp Ser Asp Ser Ala Ala Lys Gln Leu Gly Leu Ala Glu Ala 
1               5                   10                  15      


Ala Ala Val Ala Ala Ala Ala Ala Val Ala Ala Ala Ala Ala Ala Ala 
            20                  25                  30          


Ala Gly Gly Glu Ala Glu Glu Pro Val Leu Ser Arg Asp Glu Asp Ser 
        35                  40                  45              


Glu Glu Asp Ala Asp Ser Glu Ala Glu Arg Glu Thr Pro Arg Val Thr 
    50                  55                  60                  


Ala Val Ala Val Met Ala Ala Glu Pro Gly His Met Asp Met Gly Ala 
65                  70                  75                  80  


Glu Ala Leu Pro Gly Pro Asp Glu Ala Ala Ala Ala Ala Ala Phe Ala 
                85                  90                  95      


Glu Val Thr Thr Val Thr Val Ala Asn Val Gly Ala Ala Ala Asp Asn 
            100                 105                 110         


Val Phe Thr Thr Ser Val Ala Asn Ala Ala Ser Ile Ser Gly His Val 
        115                 120                 125             


Leu Ser Gly Arg Thr Ala Leu Gln Ile Gly Asp Ser Leu Asn Thr Glu 
    130                 135                 140                 


Lys Ala Thr Leu Ile Val Val His Thr Asp Gly Ser Ile Val Glu Thr 
145                 150                 155                 160 


Thr Gly Leu Lys Gly Pro Ala Ala Pro Leu Thr Pro Gly Pro Gln Ser 
                165                 170                 175     


Pro Pro Thr Pro Leu Ala Pro Gly Gln Glu Lys Gly Gly Thr Lys Tyr 
            180                 185                 190         


Asn Trp Asp Pro Ser Val Tyr Asp Ser Glu Leu Pro Val Arg Cys Arg 
        195                 200                 205             


Asn Ile Ser Gly Thr Leu Tyr Lys Asn Arg Leu Gly Ser Gly Gly Arg 
    210                 215                 220                 


Gly Arg Cys Ile Lys Gln Gly Glu Asn Trp Tyr Ser Pro Thr Glu Phe 
225                 230                 235                 240 


Glu Ala Met Ala Gly Arg Ala Ser Ser Lys Asp Trp Lys Arg Ser Ile 
                245                 250                 255     


Arg Tyr Ala Gly Arg Pro Leu Gln Cys Leu Ile Gln Asp Gly Ile Leu 
            260                 265                 270         


Asn Pro His Ala Ala Ser Cys Thr Cys Ala Ala Cys Cys Asp Asp Met 
        275                 280                 285             


Thr Leu Ser Gly Pro Val Arg Leu Phe Val Pro Tyr Lys Arg Arg Lys 
    290                 295                 300                 


Lys Glu Asn Glu Leu Pro Thr Thr Pro Val Lys Lys Asp Ser Pro Lys 
305                 310                 315                 320 


Asn Ile Thr Leu Leu Pro Ala Thr Ala Ala Thr Thr Phe Thr Val Thr 
                325                 330                 335     


Pro Ser Gly Gln Ile Thr Thr Ser Gly Ala Leu Thr Phe Asp Arg Ala 
            340                 345                 350         


Ser Thr Val Glu Ala Thr Ala Val Ile Ser Glu Ser Pro Ala Gln Gly 
        355                 360                 365             


Asp Val Phe Ala Gly Ala Thr Val Gln Glu Ala Ser Val Gln Pro Pro 
    370                 375                 380                 


Cys Arg Ala Ser His Pro Glu Pro His Tyr Pro Gly Tyr Gln Asp Ser 
385                 390                 395                 400 


Cys Gln Ile Ala Pro Phe Pro Glu Ala Ala Leu Pro Thr Ser His Pro 
                405                 410                 415     


Lys Ile Val Leu Thr Ser Leu Pro Ala Leu Ala Val Pro Pro Pro Thr 
            420                 425                 430         


Pro Thr Lys Ala Ala Pro Pro Ala Leu Val Asn Gly Leu Glu Leu Ser 
        435                 440                 445             


Glu Pro Arg Ser Trp Leu Tyr Leu Glu Glu Met Val Asn Ser Leu Leu 
    450                 455                 460                 


Asn Thr Ala Gln Gln Leu Lys Thr Leu Phe Glu Gln Ala Lys His Ala 
465                 470                 475                 480 


Ser Thr Tyr Arg Glu Ala Ala Thr Asn Gln Ala Lys Ile His Ala Asp 
                485                 490                 495     


Ala Glu Arg Lys Glu Gln Ser Cys Val Asn Cys Gly Arg Glu Ala Met 
            500                 505                 510         


Ser Glu Cys Thr Gly Cys His Lys Val Asn Tyr Cys Ser Thr Phe Cys 
        515                 520                 525             


Gln Arg Lys Asp Trp Lys Asp His Gln His Ile Cys Gly Gln Ser Ala 
    530                 535                 540                 


Ala Val Thr Val Gln Ala Asp Glu Val His Val Ala Glu Ser Val Met 
545                 550                 555                 560 


Glu Lys Val Thr Val 
                565 


<210>  4759
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  4759

Met Thr Ala Ala Ser Arg Ala Asn Pro Tyr Ser Ile Val Ser Ser Glu 
1               5                   10                  15      


Glu Asp Gly Leu His Leu Val Thr Met Ser Gly Ala Asn Gly Phe Gly 
            20                  25                  30          


Asn Gly Lys Val His Thr Arg Arg Arg Cys Arg Asn Arg Phe Val Lys 
        35                  40                  45              


Lys Asn Gly Gln Cys Asn Ile Glu Phe Ala Asn Met Asp Glu Lys Ser 
    50                  55                  60                  


Gln Arg Tyr Leu Ala Asp Met Phe Thr Thr Cys Val Asp Ile Arg Trp 
65                  70                  75                  80  


Arg Tyr Met Leu Leu Ile Phe Ser Leu Ala Phe Leu Ala Ser Trp Leu 
                85                  90                  95      


Leu Phe Gly Ile Ile Phe Trp Val Ile Ala Val Ala His Gly Asp Leu 
            100                 105                 110         


Glu Pro Ala Glu Gly Arg Gly Arg Thr Pro Cys Val Met Gln Val His 
        115                 120                 125             


Gly Phe Met Ala Ala Phe Leu Phe Ser Ile Glu Thr Gln Thr Thr Ile 
    130                 135                 140                 


Gly Tyr Gly Leu Arg Cys Val Thr Glu Glu Cys Pro Val Ala Val Phe 
145                 150                 155                 160 


Met Val Val Ala Gln Ser Ile Val Gly Cys Ile Ile Asp Ser Phe Met 
                165                 170                 175     


Ile Gly Ala Ile Met Ala Lys Met Ala Arg Pro Lys Lys Arg Ala Gln 
            180                 185                 190         


Thr Leu Leu Phe Ser His Asn Ala Val Val Ala Leu Arg Asp Gly Lys 
        195                 200                 205             


Leu Cys Leu Met Trp Arg Val Gly Asn Leu Arg Lys Ser His Ile Val 
    210                 215                 220                 


Glu Ala His Val Arg Ala Gln Leu Ile Lys Pro Arg Val Thr Glu Glu 
225                 230                 235                 240 


Gly Glu Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asp Val Gly Phe Asp 
                245                 250                 255     


Lys Gly Leu Asp Arg Ile Phe Leu Val Ser Pro Ile Thr Ile Leu His 
            260                 265                 270         


Glu Ile Asp Glu Ala Ser Pro Leu Phe Gly Ile Ser Arg Gln Asp Leu 
        275                 280                 285             


Glu Thr Asp Asp Phe Glu Ile Val Val Ile Leu Glu Gly Met Val Glu 
    290                 295                 300                 


Ala Thr Ala Met Thr Thr Gln Ala Arg Ser Ser Tyr Leu Ala Asn Glu 
305                 310                 315                 320 


Ile Leu Trp Gly His Arg Phe Glu Pro Val Leu Phe Glu Glu Lys Asn 
                325                 330                 335     


Gln Tyr Lys Ile Asp Tyr Ser His Phe His Lys Thr Tyr Glu Val Pro 
            340                 345                 350         


Ser Thr Pro Arg Cys Ser Ala Lys Asp Leu Val Glu Asn Lys Phe Leu 
        355                 360                 365             


Leu Pro Ser Ala Asn Ser Phe Cys Tyr Glu Asn Glu Leu Ala Phe Leu 
    370                 375                 380                 


Ser Arg Asp Glu Glu Asp Glu Ala Asp Gly Asp Gln Asp Gly Arg Ser 
385                 390                 395                 400 


Arg Asp Gly Leu Ser Pro Gln Ala Arg His Asp Phe Asp Arg Leu Gln 
                405                 410                 415     


Ala Gly Gly Gly Val Leu Glu Gln Arg Pro Tyr Arg Arg Glu Ser Glu 
            420                 425                 430         


Ile 
    


<210>  4760
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  4760

Met Ala Cys Thr Gly Trp Thr Ser Pro Leu Pro Leu Cys Val Cys Leu 
1               5                   10                  15      


Leu Leu Thr Cys Gly Phe Ala Glu Ala Gly Lys Leu Leu Val Val Pro 
            20                  25                  30          


Met Asp Gly Ser His Trp Phe Thr Met Arg Ser Val Val Glu Lys Leu 
        35                  40                  45              


Ile Leu Arg Gly His Glu Val Val Val Val Met Pro Glu Val Ser Trp 
    50                  55                  60                  


Gln Leu Gly Arg Ser Leu Asn Cys Thr Val Lys Thr Tyr Ser Thr Ser 
65                  70                  75                  80  


Tyr Thr Leu Glu Asp Leu Asp Arg Glu Phe Lys Ala Phe Ala His Ala 
                85                  90                  95      


Gln Trp Lys Ala Gln Val Arg Ser Ile Tyr Ser Leu Leu Met Gly Ser 
            100                 105                 110         


Tyr Asn Asp Ile Phe Asp Leu Phe Phe Ser Asn Cys Arg Ser Leu Phe 
        115                 120                 125             


Lys Asp Lys Lys Leu Val Glu Tyr Leu Lys Glu Ser Ser Phe Asp Ala 
    130                 135                 140                 


Val Phe Leu Asp Pro Phe Asp Asn Cys Gly Leu Ile Val Ala Lys Tyr 
145                 150                 155                 160 


Phe Ser Leu Pro Ser Val Val Phe Ala Arg Gly Ile Leu Cys His Tyr 
                165                 170                 175     


Leu Glu Glu Gly Ala Gln Cys Pro Ala Pro Leu Ser Tyr Val Pro Arg 
            180                 185                 190         


Ile Leu Leu Gly Phe Ser Asp Ala Met Thr Phe Lys Glu Arg Val Arg 
        195                 200                 205             


Asn His Ile Met His Leu Glu Glu His Leu Leu Cys His Arg Phe Phe 
    210                 215                 220                 


Lys Asn Ala Leu Glu Ile Ala Ser Glu Ile Leu Gln Thr Pro Val Thr 
225                 230                 235                 240 


Glu Tyr Asp Leu Tyr Ser His Thr Ser Ile Trp Leu Leu Arg Thr Asp 
                245                 250                 255     


Phe Val Leu Asp Tyr Pro Lys Pro Val Met Pro Asn Met Ile Phe Ile 
            260                 265                 270         


Gly Gly Ile Asn Cys His Gln Gly Lys Pro Leu Pro Met Glu Phe Glu 
        275                 280                 285             


Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val Val Phe Ser Leu 
    290                 295                 300                 


Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala Met Ala Ile Ala 
305                 310                 315                 320 


Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp Arg Tyr Thr Gly 
                325                 330                 335     


Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu Val Lys Trp Leu 
            340                 345                 350         


Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg Ala Phe Ile Thr 
        355                 360                 365             


His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys Asn Gly Val Pro 
    370                 375                 380                 


Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp Asn Ala Lys Arg 
385                 390                 395                 400 


Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val Leu Glu Met Thr 
                405                 410                 415     


Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile Asn Asp Lys Ser 
            420                 425                 430         


Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His Lys Asp Arg Pro 
        435                 440                 445             


Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu Phe Val Met Arg 
    450                 455                 460                 


His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His Asp Leu Thr Trp 
465                 470                 475                 480 


Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu Leu Ala Val Val 
                485                 490                 495     


Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala Tyr Gly Tyr Arg 
            500                 505                 510         


Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala His Lys Ser Lys 
        515                 520                 525             


Thr His 
    530 


<210>  4761
<211>  1256
<212>  PRT
<213>  Homo sapiens

<400>  4761

Met Pro Gly Pro Arg Gly Ala Ala Gly Gly Leu Ala Pro Glu Met Arg 
1               5                   10                  15      


Gly Ala Gly Ala Ala Gly Leu Leu Ala Leu Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Gly Leu Gly Gly Arg Val Glu Gly Gly Pro Ala Gly Glu 
        35                  40                  45              


Arg Gly Ala Gly Gly Gly Gly Ala Leu Ala Arg Glu Arg Phe Lys Val 
    50                  55                  60                  


Val Phe Ala Pro Val Ile Cys Lys Arg Thr Cys Leu Lys Gly Gln Cys 
65                  70                  75                  80  


Arg Asp Ser Cys Gln Gln Gly Ser Asn Met Thr Leu Ile Gly Glu Asn 
                85                  90                  95      


Gly His Ser Thr Asp Thr Leu Thr Gly Ser Gly Phe Arg Val Val Val 
            100                 105                 110         


Cys Pro Leu Pro Cys Met Asn Gly Gly Gln Cys Ser Ser Arg Asn Gln 
        115                 120                 125             


Cys Leu Cys Pro Pro Asp Phe Thr Gly Arg Phe Cys Gln Val Pro Ala 
    130                 135                 140                 


Gly Gly Ala Gly Gly Gly Thr Gly Gly Ser Gly Pro Gly Leu Ser Arg 
145                 150                 155                 160 


Thr Gly Ala Leu Ser Thr Gly Ala Leu Pro Pro Leu Ala Pro Glu Gly 
                165                 170                 175     


Asp Ser Val Ala Ser Lys His Ala Ile Tyr Ala Val Gln Val Ile Ala 
            180                 185                 190         


Asp Pro Pro Gly Pro Gly Glu Gly Pro Pro Ala Gln His Ala Ala Phe 
        195                 200                 205             


Leu Val Pro Leu Gly Pro Gly Gln Ile Ser Ala Glu Val Gln Ala Pro 
    210                 215                 220                 


Pro Pro Val Val Asn Val Arg Val His His Pro Pro Glu Ala Ser Val 
225                 230                 235                 240 


Gln Val His Arg Ile Glu Ser Ser Asn Ala Glu Ser Ala Ala Pro Ser 
                245                 250                 255     


Gln His Leu Leu Pro His Pro Lys Pro Ser His Pro Arg Pro Pro Thr 
            260                 265                 270         


Gln Lys Pro Leu Gly Arg Cys Phe Gln Asp Thr Leu Pro Lys Gln Pro 
        275                 280                 285             


Cys Gly Ser Asn Pro Leu Pro Gly Leu Thr Lys Gln Glu Asp Cys Cys 
    290                 295                 300                 


Gly Ser Ile Gly Thr Ala Trp Gly Gln Ser Lys Cys His Lys Cys Pro 
305                 310                 315                 320 


Gln Leu Gln Tyr Thr Gly Val Gln Lys Pro Gly Pro Val Arg Gly Glu 
                325                 330                 335     


Val Gly Ala Asp Cys Pro Gln Gly Tyr Lys Arg Leu Asn Ser Thr His 
            340                 345                 350         


Cys Gln Asp Ile Asn Glu Cys Ala Met Pro Gly Val Cys Arg His Gly 
        355                 360                 365             


Asp Cys Leu Asn Asn Pro Gly Ser Tyr Arg Cys Val Cys Pro Pro Gly 
    370                 375                 380                 


His Ser Leu Gly Pro Ser Arg Thr Gln Cys Ile Ala Asp Lys Pro Glu 
385                 390                 395                 400 


Glu Lys Ser Leu Cys Phe Arg Leu Val Ser Pro Glu His Gln Cys Gln 
                405                 410                 415     


His Pro Leu Thr Thr Arg Leu Thr Arg Gln Leu Cys Cys Cys Ser Val 
            420                 425                 430         


Gly Lys Ala Trp Gly Ala Arg Cys Gln Arg Cys Pro Thr Asp Gly Thr 
        435                 440                 445             


Ala Ala Phe Lys Glu Ile Cys Pro Ala Gly Lys Gly Tyr His Ile Leu 
    450                 455                 460                 


Thr Ser His Gln Thr Leu Thr Ile Gln Gly Glu Ser Asp Phe Ser Leu 
465                 470                 475                 480 


Phe Leu His Pro Asp Gly Pro Pro Lys Pro Gln Gln Leu Pro Glu Ser 
                485                 490                 495     


Pro Ser Gln Ala Pro Pro Pro Glu Asp Thr Glu Glu Glu Arg Gly Val 
            500                 505                 510         


Thr Thr Asp Ser Pro Val Ser Glu Glu Arg Ser Val Gln Gln Ser His 
        515                 520                 525             


Pro Thr Ala Thr Thr Thr Pro Ala Arg Pro Tyr Pro Glu Leu Ile Ser 
    530                 535                 540                 


Arg Pro Ser Pro Pro Thr Met Arg Trp Phe Leu Pro Asp Leu Pro Pro 
545                 550                 555                 560 


Ser Arg Ser Ala Val Glu Ile Ala Pro Thr Gln Val Thr Glu Thr Asp 
                565                 570                 575     


Glu Cys Arg Leu Asn Gln Asn Ile Cys Gly His Gly Glu Cys Val Pro 
            580                 585                 590         


Gly Pro Pro Asp Tyr Ser Cys His Cys Asn Pro Gly Tyr Arg Ser His 
        595                 600                 605             


Pro Gln His Arg Tyr Cys Val Asp Val Asn Glu Cys Glu Ala Glu Pro 
    610                 615                 620                 


Cys Gly Pro Gly Arg Gly Ile Cys Met Asn Thr Gly Gly Ser Tyr Asn 
625                 630                 635                 640 


Cys His Cys Asn Arg Gly Tyr Arg Leu His Val Gly Ala Gly Gly Arg 
                645                 650                 655     


Ser Cys Val Asp Leu Asn Glu Cys Ala Lys Pro His Leu Cys Gly Asp 
            660                 665                 670         


Gly Gly Phe Cys Ile Asn Phe Pro Gly His Tyr Lys Cys Asn Cys Tyr 
        675                 680                 685             


Pro Gly Tyr Arg Leu Lys Ala Ser Arg Pro Pro Val Cys Glu Asp Ile 
    690                 695                 700                 


Asp Glu Cys Arg Asp Pro Ser Ser Cys Pro Asp Gly Lys Cys Glu Asn 
705                 710                 715                 720 


Lys Pro Gly Ser Phe Lys Cys Ile Ala Cys Gln Pro Gly Tyr Arg Ser 
                725                 730                 735     


Gln Gly Gly Gly Ala Cys Arg Asp Val Asn Glu Cys Ala Glu Gly Ser 
            740                 745                 750         


Pro Cys Ser Pro Gly Trp Cys Glu Asn Leu Pro Gly Ser Phe Arg Cys 
        755                 760                 765             


Thr Cys Ala Gln Gly Tyr Ala Pro Ala Pro Asp Gly Arg Ser Cys Leu 
    770                 775                 780                 


Asp Val Asp Glu Cys Glu Ala Gly Asp Val Cys Asp Asn Gly Ile Cys 
785                 790                 795                 800 


Ser Asn Thr Pro Gly Ser Phe Gln Cys Gln Cys Leu Ser Gly Tyr His 
                805                 810                 815     


Leu Ser Arg Asp Arg Ser His Cys Glu Asp Ile Asp Glu Cys Asp Phe 
            820                 825                 830         


Pro Ala Ala Cys Ile Gly Gly Asp Cys Ile Asn Thr Asn Gly Ser Tyr 
        835                 840                 845             


Arg Cys Leu Cys Pro Gln Gly His Arg Leu Val Gly Gly Arg Lys Cys 
    850                 855                 860                 


Gln Asp Ile Asp Glu Cys Ser Gln Asp Pro Ser Leu Cys Leu Pro His 
865                 870                 875                 880 


Gly Ala Cys Lys Asn Leu Gln Gly Ser Tyr Val Cys Val Cys Asp Glu 
                885                 890                 895     


Gly Phe Thr Pro Thr Gln Asp Gln His Gly Cys Glu Glu Val Glu Gln 
            900                 905                 910         


Pro His His Lys Lys Glu Cys Tyr Leu Asn Phe Asp Asp Thr Val Phe 
        915                 920                 925             


Cys Asp Ser Val Leu Ala Thr Asn Val Thr Gln Gln Glu Cys Cys Cys 
    930                 935                 940                 


Ser Leu Gly Ala Gly Trp Gly Asp His Cys Glu Ile Tyr Pro Cys Pro 
945                 950                 955                 960 


Val Tyr Ser Ser Ala Glu Phe His Ser Leu Cys Pro Asp Gly Lys Gly 
                965                 970                 975     


Tyr Thr Gln Asp Asn Asn Ile Val Asn Tyr Gly Ile Pro Ala His Arg 
            980                 985                 990         


Asp Ile Asp Glu Cys Met Leu Phe  Gly Ser Glu Ile Cys  Lys Glu Gly 
        995                 1000                 1005             


Lys Cys  Val Asn Thr Gln Pro  Gly Tyr Glu Cys Tyr  Cys Lys Gln 
    1010                 1015                 1020             


Gly Phe  Tyr Tyr Asp Gly Asn  Leu Leu Glu Cys Val  Asp Val Asp 
    1025                 1030                 1035             


Glu Cys  Leu Asp Glu Ser Asn  Cys Arg Asn Gly Val  Cys Glu Asn 
    1040                 1045                 1050             


Thr Arg  Gly Gly Tyr Arg Cys  Ala Cys Thr Pro Pro  Ala Glu Tyr 
    1055                 1060                 1065             


Ser Pro  Ala Gln Arg Gln Cys  Leu Ser Pro Glu Glu  Met Glu Arg 
    1070                 1075                 1080             


Ala Pro  Glu Arg Arg Asp Val  Cys Trp Ser Gln Arg  Gly Glu Asp 
    1085                 1090                 1095             


Gly Met  Cys Ala Gly Pro Leu  Ala Gly Pro Ala Leu  Thr Phe Asp 
    1100                 1105                 1110             


Asp Cys  Cys Cys Arg Gln Gly  Arg Gly Trp Gly Ala  Gln Cys Arg 
    1115                 1120                 1125             


Pro Cys  Pro Pro Arg Gly Ala  Gly Ser His Cys Pro  Thr Ser Gln 
    1130                 1135                 1140             


Ser Glu  Ser Asn Ser Phe Trp  Asp Thr Ser Pro Leu  Leu Leu Gly 
    1145                 1150                 1155             


Lys Pro  Pro Arg Asp Glu Asp  Ser Ser Glu Glu Asp  Ser Asp Glu 
    1160                 1165                 1170             


Cys Arg  Cys Val Ser Gly Arg  Cys Val Pro Arg Pro  Gly Gly Ala 
    1175                 1180                 1185             


Val Cys  Glu Cys Pro Gly Gly  Phe Gln Leu Asp Ala  Ser Arg Ala 
    1190                 1195                 1200             


Arg Cys  Val Asp Ile Asp Glu  Cys Arg Glu Leu Asn  Gln Arg Gly 
    1205                 1210                 1215             


Leu Leu  Cys Lys Ser Glu Arg  Cys Val Asn Thr Ser  Gly Ser Phe 
    1220                 1225                 1230             


Arg Cys  Val Cys Lys Ala Gly  Phe Ala Arg Ser Arg  Pro His Gly 
    1235                 1240                 1245             


Ala Cys  Val Pro Gln Arg Arg  Arg 
    1250                 1255     


<210>  4762
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  4762

Met Gly Pro Leu Ile Asn Arg Cys Lys Lys Ile Leu Leu Pro Thr Thr 
1               5                   10                  15      


Val Pro Pro Ala Thr Met Arg Ile Trp Leu Leu Gly Gly Leu Leu Pro 
            20                  25                  30          


Phe Leu Leu Leu Leu Ser Gly Leu Gln Arg Pro Thr Glu Gly Ser Glu 
        35                  40                  45              


Val Ala Ile Lys Ile Asp Phe Asp Phe Ala Pro Gly Ser Phe Asp Asp 
    50                  55                  60                  


Gln Tyr Gln Gly Cys Ser Lys Gln Val Met Glu Lys Leu Thr Gln Gly 
65                  70                  75                  80  


Asp Tyr Phe Thr Lys Asp Ile Glu Ala Gln Lys Asn Tyr Phe Arg Met 
                85                  90                  95      


Trp Gln Lys Ala His Leu Ala Trp Leu Asn Gln Gly Lys Val Leu Pro 
            100                 105                 110         


Gln Asn Met Thr Thr Thr His Ala Val Ala Ile Leu Phe Tyr Thr Leu 
        115                 120                 125             


Asn Ser Asn Val His Ser Asp Phe Thr Arg Ala Met Ala Ser Val Ala 
    130                 135                 140                 


Arg Thr Pro Gln Gln Tyr Glu Arg Ser Phe His Phe Lys Tyr Leu His 
145                 150                 155                 160 


Tyr Tyr Leu Thr Ser Ala Ile Gln Leu Leu Arg Lys Asp Ser Ile Met 
                165                 170                 175     


Glu Asn Gly Thr Leu Cys Tyr Glu Val His Tyr Arg Thr Lys Asp Val 
            180                 185                 190         


His Phe Asn Ala Tyr Thr Gly Ala Thr Ile Arg Phe Gly Gln Phe Leu 
        195                 200                 205             


Ser Thr Ser Leu Leu Lys Glu Glu Ala Gln Glu Phe Gly Asn Gln Thr 
    210                 215                 220                 


Leu Phe Thr Ile Phe Thr Cys Leu Gly Ala Pro Val Gln Tyr Phe Ser 
225                 230                 235                 240 


Leu Lys Lys Glu Val Leu Ile Pro Pro Tyr Glu Leu Phe Lys Val Ile 
                245                 250                 255     


Asn Met Ser Tyr His Pro Arg Gly Asp Trp Leu Gln Leu Arg Ser Thr 
            260                 265                 270         


Gly Asn Leu Ser Thr Tyr Asn Cys Gln Leu Leu Lys Ala Ser Ser Lys 
        275                 280                 285             


Lys Cys Ile Pro Asp Pro Ile Ala Ile Ala Ser Leu Ser Phe Leu Thr 
    290                 295                 300                 


Ser Val Ile Ile Phe Ser Lys Ser Arg Val 
305                 310                 


<210>  4763
<211>  890
<212>  PRT
<213>  Homo sapiens

<400>  4763

Met Glu Gly Gly Gly Lys Pro Asn Ser Ser Ser Asn Ser Arg Asp Asp 
1               5                   10                  15      


Gly Asn Ser Val Phe Pro Ala Lys Ala Ser Ala Thr Gly Ala Gly Pro 
            20                  25                  30          


Ala Ala Ala Glu Lys Arg Leu Gly Thr Pro Pro Gly Gly Gly Gly Ala 
        35                  40                  45              


Gly Ala Lys Glu His Gly Asn Ser Val Cys Phe Lys Val Asp Gly Gly 
    50                  55                  60                  


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Glu Pro Ala Gly Gly 
65                  70                  75                  80  


Phe Glu Asp Ala Glu Gly Pro Arg Arg Gln Tyr Gly Phe Met Gln Arg 
                85                  90                  95      


Gln Phe Thr Ser Met Leu Gln Pro Gly Val Asn Lys Phe Ser Leu Arg 
            100                 105                 110         


Met Phe Gly Ser Gln Lys Ala Val Glu Lys Glu Gln Glu Arg Val Lys 
        115                 120                 125             


Thr Ala Gly Phe Trp Ile Ile His Pro Tyr Ser Asp Phe Arg Phe Tyr 
    130                 135                 140                 


Trp Asp Leu Ile Met Leu Ile Met Met Val Gly Asn Leu Val Ile Ile 
145                 150                 155                 160 


Pro Val Gly Ile Thr Phe Phe Thr Glu Gln Thr Thr Thr Pro Trp Ile 
                165                 170                 175     


Ile Phe Asn Val Ala Ser Asp Thr Val Phe Leu Leu Asp Leu Ile Met 
            180                 185                 190         


Asn Phe Arg Thr Gly Thr Val Asn Glu Asp Ser Ser Glu Ile Ile Leu 
        195                 200                 205             


Asp Pro Lys Val Ile Lys Met Asn Tyr Leu Lys Ser Trp Phe Val Val 
    210                 215                 220                 


Asp Phe Ile Ser Ser Ile Pro Val Asp Tyr Ile Phe Leu Ile Val Glu 
225                 230                 235                 240 


Lys Gly Met Asp Ser Glu Val Tyr Lys Thr Ala Arg Ala Leu Arg Ile 
                245                 250                 255     


Val Arg Phe Thr Lys Ile Leu Ser Leu Leu Arg Leu Leu Arg Leu Ser 
            260                 265                 270         


Arg Leu Ile Arg Tyr Ile His Gln Trp Glu Glu Ile Phe His Met Thr 
        275                 280                 285             


Tyr Asp Leu Ala Ser Ala Val Val Arg Ile Phe Asn Leu Ile Gly Met 
    290                 295                 300                 


Met Leu Leu Leu Cys His Trp Asp Gly Cys Leu Gln Phe Leu Val Pro 
305                 310                 315                 320 


Leu Leu Gln Asp Phe Pro Pro Asp Cys Trp Val Ser Leu Asn Glu Met 
                325                 330                 335     


Val Asn Asp Ser Trp Gly Lys Gln Tyr Ser Tyr Ala Leu Phe Lys Ala 
            340                 345                 350         


Met Ser His Met Leu Cys Ile Gly Tyr Gly Ala Gln Ala Pro Val Ser 
        355                 360                 365             


Met Ser Asp Leu Trp Ile Thr Met Leu Ser Met Ile Val Gly Ala Thr 
    370                 375                 380                 


Cys Tyr Ala Met Phe Val Gly His Ala Thr Ala Leu Ile Gln Ser Leu 
385                 390                 395                 400 


Asp Ser Ser Arg Arg Gln Tyr Gln Glu Lys Tyr Lys Gln Val Glu Gln 
                405                 410                 415     


Tyr Met Ser Phe His Lys Leu Pro Ala Asp Met Arg Gln Lys Ile His 
            420                 425                 430         


Asp Tyr Tyr Glu His Arg Tyr Gln Gly Lys Ile Phe Asp Glu Glu Asn 
        435                 440                 445             


Ile Leu Asn Glu Leu Asn Asp Pro Leu Arg Glu Glu Ile Val Asn Phe 
    450                 455                 460                 


Asn Cys Arg Lys Leu Val Ala Thr Met Pro Leu Phe Ala Asn Ala Asp 
465                 470                 475                 480 


Pro Asn Phe Val Thr Ala Met Leu Ser Lys Leu Arg Phe Glu Val Phe 
                485                 490                 495     


Gln Pro Gly Asp Tyr Ile Ile Arg Glu Gly Ala Val Gly Lys Lys Met 
            500                 505                 510         


Tyr Phe Ile Gln His Gly Val Ala Gly Val Ile Thr Lys Ser Ser Lys 
        515                 520                 525             


Glu Met Lys Leu Thr Asp Gly Ser Tyr Phe Gly Glu Ile Cys Leu Leu 
    530                 535                 540                 


Thr Lys Gly Arg Arg Thr Ala Ser Val Arg Ala Asp Thr Tyr Cys Arg 
545                 550                 555                 560 


Leu Tyr Ser Leu Ser Val Asp Asn Phe Asn Glu Val Leu Glu Glu Tyr 
                565                 570                 575     


Pro Met Met Arg Arg Ala Phe Glu Thr Val Ala Ile Asp Arg Leu Asp 
            580                 585                 590         


Arg Ile Gly Lys Lys Asn Ser Ile Leu Leu Gln Lys Phe Gln Lys Asp 
        595                 600                 605             


Leu Asn Thr Gly Val Phe Asn Asn Gln Glu Asn Glu Ile Leu Lys Gln 
    610                 615                 620                 


Ile Val Lys His Asp Arg Glu Met Val Gln Ala Ile Ala Pro Ile Asn 
625                 630                 635                 640 


Tyr Pro Gln Met Thr Thr Leu Asn Ser Thr Ser Ser Thr Thr Thr Pro 
                645                 650                 655     


Thr Ser Arg Met Arg Thr Gln Ser Pro Pro Val Tyr Thr Ala Thr Ser 
            660                 665                 670         


Leu Ser His Ser Asn Leu His Ser Pro Ser Pro Ser Thr Gln Thr Pro 
        675                 680                 685             


Gln Pro Ser Ala Ile Leu Ser Pro Cys Ser Tyr Thr Thr Ala Val Cys 
    690                 695                 700                 


Ser Pro Pro Val Gln Ser Pro Leu Ala Ala Arg Thr Phe His Tyr Ala 
705                 710                 715                 720 


Ser Pro Thr Ala Ser Gln Leu Ser Leu Met Gln Gln Gln Pro Gln Gln 
                725                 730                 735     


Gln Val Gln Gln Ser Gln Pro Pro Gln Thr Gln Pro Gln Gln Pro Ser 
            740                 745                 750         


Pro Gln Pro Gln Thr Pro Gly Ser Ser Thr Pro Lys Asn Glu Val His 
        755                 760                 765             


Lys Ser Thr Gln Ala Leu His Asn Thr Asn Leu Thr Arg Glu Val Arg 
    770                 775                 780                 


Pro Leu Ser Ala Ser Gln Pro Ser Leu Pro His Glu Val Ser Thr Leu 
785                 790                 795                 800 


Ile Ser Arg Pro His Pro Thr Val Gly Glu Ser Leu Ala Ser Ile Pro 
                805                 810                 815     


Gln Pro Val Thr Ala Val Pro Gly Thr Gly Leu Gln Ala Gly Gly Arg 
            820                 825                 830         


Ser Thr Val Pro Gln Arg Val Thr Leu Phe Arg Gln Met Ser Ser Gly 
        835                 840                 845             


Ala Ile Pro Pro Asn Arg Gly Val Pro Pro Ala Pro Pro Pro Pro Ala 
    850                 855                 860                 


Ala Ala Leu Pro Arg Glu Ser Ser Ser Val Leu Asn Thr Asp Pro Asp 
865                 870                 875                 880 


Ala Glu Lys Pro Arg Phe Ala Ser Asn Leu 
                885                 890 


<210>  4764
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  4764

Met Ala Arg Arg Ala Gly Gly Ala Arg Met Phe Gly Ser Leu Leu Leu 
1               5                   10                  15      


Phe Ala Leu Leu Ala Ala Gly Val Ala Pro Leu Ser Trp Asp Leu Pro 
            20                  25                  30          


Glu Pro Arg Ser Arg Ala Ser Lys Ile Arg Val His Ser Arg Gly Asn 
        35                  40                  45              


Leu Trp Ala Thr Gly His Phe Met Gly Lys Lys Ser Leu Glu Pro Ser 
    50                  55                  60                  


Ser Pro Ser Pro Leu Gly Thr Ala Pro His Thr Ser Leu Arg Asp Gln 
65                  70                  75                  80  


Arg Leu Gln Leu Ser His Asp Leu Leu Gly Ile Leu Leu Leu Lys Lys 
                85                  90                  95      


Ala Leu Gly Val Ser Leu Ser Arg Pro Ala Pro Gln Ile Gln Tyr Arg 
            100                 105                 110         


Arg Leu Leu Val Gln Ile Leu Gln Lys 
        115                 120     


<210>  4765
<211>  729
<212>  PRT
<213>  Homo sapiens

<400>  4765

Met Asn Pro Phe Gln Lys Asn Glu Ser Lys Glu Thr Leu Phe Ser Pro 
1               5                   10                  15      


Val Ser Ile Glu Glu Val Pro Pro Arg Pro Pro Ser Pro Pro Lys Lys 
            20                  25                  30          


Pro Ser Pro Thr Ile Cys Gly Ser Asn Tyr Pro Leu Ser Ile Ala Phe 
        35                  40                  45              


Ile Val Val Asn Glu Phe Cys Glu Arg Phe Ser Tyr Tyr Gly Met Lys 
    50                  55                  60                  


Ala Val Leu Ile Leu Tyr Phe Leu Tyr Phe Leu His Trp Asn Glu Asp 
65                  70                  75                  80  


Thr Ser Thr Ser Ile Tyr His Ala Phe Ser Ser Leu Cys Tyr Phe Thr 
                85                  90                  95      


Pro Ile Leu Gly Ala Ala Ile Ala Asp Ser Trp Leu Gly Lys Phe Lys 
            100                 105                 110         


Thr Ile Ile Tyr Leu Ser Leu Val Tyr Val Leu Gly His Val Ile Lys 
        115                 120                 125             


Ser Leu Gly Ala Leu Pro Ile Leu Gly Gly Gln Val Val His Thr Val 
    130                 135                 140                 


Leu Ser Leu Ile Gly Leu Ser Leu Ile Ala Leu Gly Thr Gly Gly Ile 
145                 150                 155                 160 


Lys Pro Cys Val Ala Ala Phe Gly Gly Asp Gln Phe Glu Glu Lys His 
                165                 170                 175     


Ala Glu Glu Arg Thr Arg Tyr Phe Ser Val Phe Tyr Leu Ser Ile Asn 
            180                 185                 190         


Ala Gly Ser Leu Ile Ser Thr Phe Ile Thr Pro Met Leu Arg Gly Asp 
        195                 200                 205             


Val Gln Cys Phe Gly Glu Asp Cys Tyr Ala Leu Ala Phe Gly Val Pro 
    210                 215                 220                 


Gly Leu Leu Met Val Ile Ala Leu Val Val Phe Ala Met Gly Ser Lys 
225                 230                 235                 240 


Ile Tyr Asn Lys Pro Pro Pro Glu Gly Asn Ile Val Ala Gln Val Phe 
                245                 250                 255     


Lys Cys Ile Trp Phe Ala Ile Ser Asn Arg Phe Lys Asn Arg Ser Gly 
            260                 265                 270         


Asp Ile Pro Lys Arg Gln His Trp Leu Asp Trp Ala Ala Glu Lys Tyr 
        275                 280                 285             


Pro Lys Gln Leu Ile Met Asp Val Lys Ala Leu Thr Arg Val Leu Phe 
    290                 295                 300                 


Leu Tyr Ile Pro Leu Pro Met Phe Trp Ala Leu Leu Asp Gln Gln Gly 
305                 310                 315                 320 


Ser Arg Trp Thr Leu Gln Ala Ile Arg Met Asn Arg Asn Leu Gly Phe 
                325                 330                 335     


Phe Val Leu Gln Pro Asp Gln Met Gln Val Leu Asn Pro Leu Leu Val 
            340                 345                 350         


Leu Ile Phe Ile Pro Leu Phe Asp Phe Val Ile Tyr Arg Leu Val Ser 
        355                 360                 365             


Lys Cys Gly Ile Asn Phe Ser Ser Leu Arg Lys Met Ala Val Gly Met 
    370                 375                 380                 


Ile Leu Ala Cys Leu Ala Phe Ala Val Ala Ala Ala Val Glu Ile Lys 
385                 390                 395                 400 


Ile Asn Glu Met Ala Pro Ala Gln Pro Gly Pro Gln Glu Val Phe Leu 
                405                 410                 415     


Gln Val Leu Asn Leu Ala Asp Asp Glu Val Lys Val Thr Val Val Gly 
            420                 425                 430         


Asn Glu Asn Asn Ser Leu Leu Ile Glu Ser Ile Lys Ser Phe Gln Lys 
        435                 440                 445             


Thr Pro His Tyr Ser Lys Leu His Leu Lys Thr Lys Ser Gln Asp Phe 
    450                 455                 460                 


His Phe His Leu Lys Tyr His Asn Leu Ser Leu Tyr Thr Glu His Ser 
465                 470                 475                 480 


Val Gln Glu Lys Asn Trp Tyr Ser Leu Val Ile Arg Glu Asp Gly Asn 
                485                 490                 495     


Ser Ile Ser Ser Met Met Val Lys Asp Thr Glu Ser Arg Thr Thr Asn 
            500                 505                 510         


Gly Met Thr Thr Val Arg Phe Val Asn Thr Leu His Lys Asp Val Asn 
        515                 520                 525             


Ile Ser Leu Ser Thr Asp Thr Ser Leu Asn Val Gly Glu Asp Tyr Gly 
    530                 535                 540                 


Val Ser Ala Tyr Arg Thr Val Gln Arg Gly Glu Tyr Pro Ala Val His 
545                 550                 555                 560 


Cys Arg Thr Glu Asp Lys Asn Phe Ser Leu Asn Leu Gly Leu Leu Asp 
                565                 570                 575     


Phe Gly Ala Ala Tyr Leu Phe Val Ile Thr Asn Asn Thr Asn Gln Gly 
            580                 585                 590         


Leu Gln Ala Trp Lys Ile Glu Asp Ile Pro Ala Asn Lys Met Ser Ile 
        595                 600                 605             


Ala Trp Gln Leu Pro Gln Tyr Ala Leu Val Thr Ala Gly Glu Val Met 
    610                 615                 620                 


Phe Ser Val Thr Gly Leu Glu Phe Ser Tyr Ser Gln Ala Pro Ser Ser 
625                 630                 635                 640 


Met Lys Ser Val Leu Gln Ala Ala Trp Leu Leu Thr Ile Ala Val Gly 
                645                 650                 655     


Asn Ile Ile Val Leu Val Val Ala Gln Phe Ser Gly Leu Val Gln Trp 
            660                 665                 670         


Ala Glu Phe Ile Leu Phe Ser Cys Leu Leu Leu Val Ile Cys Leu Ile 
        675                 680                 685             


Phe Ser Ile Met Gly Tyr Tyr Tyr Val Pro Val Lys Thr Glu Asp Met 
    690                 695                 700                 


Arg Gly Pro Ala Asp Lys His Ile Pro His Ile Gln Gly Asn Met Ile 
705                 710                 715                 720 


Lys Leu Glu Thr Lys Lys Thr Lys Leu 
                725                 


<210>  4766
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  4766

Met Lys Phe Pro Ala Ser Val Leu Ala Ser Val Phe Leu Phe Val Ala 
1               5                   10                  15      


Glu Thr Thr Ala Ala Leu Ser Leu Ser Ser Thr Tyr Arg Ser Gly Gly 
            20                  25                  30          


Asp Arg Met Trp Gln Ala Leu Thr Leu Leu Phe Ser Leu Leu Pro Cys 
        35                  40                  45              


Ala Leu Val Gln Leu Thr Leu Leu Phe Val His Arg Asp Leu Ser Arg 
    50                  55                  60                  


Asp Arg Pro Leu Val Leu Leu Leu His Leu Leu Gln Leu Gly Pro Leu 
65                  70                  75                  80  


Phe Arg Cys Phe Glu Val Phe Cys Ile Tyr Phe Gln Ser Gly Asn Asn 
                85                  90                  95      


Glu Glu Pro Tyr Val Ser Ile Thr Lys Lys Arg Gln Met Pro Lys Asn 
            100                 105                 110         


Gly Leu Ser Glu Glu Ile Glu Lys Glu Val Gly Gln Ala Glu Gly Lys 
        115                 120                 125             


Leu Ile Thr His Arg Ser Ala Phe Ser Arg Ala Ser Val Ile Gln Ala 
    130                 135                 140                 


Phe Leu Gly Ser Ala Pro Gln Leu Thr Leu Gln Leu Tyr Ile Ser Val 
145                 150                 155                 160 


Met Gln Gln Asp Val Thr Val Gly Arg Ser Leu Leu Met Thr Ile Ser 
                165                 170                 175     


Leu Leu Ser Ile Val Tyr Gly Ala Leu Arg Cys Asn Ile Leu Ala Ile 
            180                 185                 190         


Lys Ile Lys Tyr Asp Glu Tyr Glu Val Lys Val Lys Pro Leu Ala Tyr 
        195                 200                 205             


Val Cys Ile Phe Leu Trp Arg Ser Phe Glu Ile Ala Thr Arg Val Val 
    210                 215                 220                 


Val Leu Val Leu Phe Thr Ser Val Leu Lys Thr Trp Val Val Val Ile 
225                 230                 235                 240 


Ile Leu Ile Asn Phe Phe Ser Phe Phe Leu Tyr Pro Trp Ile Leu Phe 
                245                 250                 255     


Trp Cys Ser Gly Ser Pro Phe Pro Glu Asn Ile Glu Lys Ala Leu Ser 
            260                 265                 270         


Arg Val Gly Thr Thr Ile Val Leu Cys Phe Leu Thr Leu Leu Tyr Thr 
        275                 280                 285             


Gly Ile Asn Met Phe Cys Trp Ser Ala Val Gln Leu Lys Ile Asp Ser 
    290                 295                 300                 


Pro Asp Leu Ile Ser Lys Ser His Asn Trp Tyr Gln Leu Leu Val Tyr 
305                 310                 315                 320 


Tyr Met Ile Arg Phe Ile Glu Asn Ala Ile Leu Leu Leu Leu Trp Tyr 
                325                 330                 335     


Leu Phe Lys Thr Asp Ile Tyr Met Tyr Val Cys Ala Pro Leu Leu Val 
            340                 345                 350         


Leu Gln Leu Leu Ile Gly Tyr Cys Thr Ala Ile Leu Phe Met Leu Val 
        355                 360                 365             


Phe Tyr Gln Phe Phe His Pro Cys Lys Lys Leu Phe Ser Ser Ser Val 
    370                 375                 380                 


Ser Glu Gly Phe Gln Arg Trp Leu Arg Cys Phe Cys Trp Ala Cys Arg 
385                 390                 395                 400 


Gln Gln Lys Pro Cys Glu Pro Ile Gly Lys Glu Asp Leu Gln Ser Ser 
                405                 410                 415     


Arg Asp Arg Asp Glu Thr Pro Ser Ser Ser Lys Thr Ser Pro Glu Pro 
            420                 425                 430         


Gly Gln Phe Leu Asn Ala Glu Asp Leu Cys Ser Ala 
        435                 440                 


<210>  4767
<211>  635
<212>  PRT
<213>  Homo sapiens

<400>  4767

Met Ser Val Gly Val Ser Thr Ser Ala Pro Leu Ser Pro Thr Ser Gly 
1               5                   10                  15      


Thr Ser Val Gly Met Ser Thr Phe Ser Ile Met Asp Tyr Val Val Phe 
            20                  25                  30          


Val Leu Leu Leu Val Leu Ser Leu Ala Ile Gly Leu Tyr His Ala Cys 
        35                  40                  45              


Arg Gly Trp Gly Arg His Thr Val Gly Glu Leu Leu Met Ala Asp Arg 
    50                  55                  60                  


Lys Met Gly Cys Leu Pro Val Ala Leu Ser Leu Leu Ala Thr Phe Gln 
65                  70                  75                  80  


Ser Ala Val Ala Ile Leu Gly Val Pro Ser Glu Ile Tyr Arg Phe Gly 
                85                  90                  95      


Thr Gln Tyr Trp Phe Leu Gly Cys Cys Tyr Phe Leu Gly Leu Leu Ile 
            100                 105                 110         


Pro Ala His Ile Phe Ile Pro Val Phe Tyr Arg Leu His Leu Thr Ser 
        115                 120                 125             


Ala Tyr Glu Tyr Leu Glu Leu Arg Phe Asn Lys Thr Val Arg Val Cys 
    130                 135                 140                 


Gly Thr Val Thr Phe Ile Phe Gln Met Val Ile Tyr Met Gly Val Val 
145                 150                 155                 160 


Leu Tyr Ala Pro Ser Leu Ala Leu Asn Ala Val Thr Gly Phe Asp Leu 
                165                 170                 175     


Trp Leu Ser Val Leu Ala Leu Gly Ile Val Cys Thr Val Tyr Thr Ala 
            180                 185                 190         


Leu Gly Gly Leu Lys Ala Val Ile Trp Thr Asp Val Phe Gln Thr Leu 
        195                 200                 205             


Val Met Phe Leu Gly Gln Leu Ala Val Ile Ile Val Gly Ser Ala Lys 
    210                 215                 220                 


Val Gly Gly Leu Gly Arg Val Trp Ala Val Ala Ser Gln His Gly Arg 
225                 230                 235                 240 


Ile Ser Gly Phe Glu Leu Asp Pro Asp Pro Phe Val Arg His Thr Phe 
                245                 250                 255     


Trp Thr Leu Ala Phe Gly Gly Val Phe Met Met Leu Ser Leu Tyr Gly 
            260                 265                 270         


Val Asn Gln Ala Gln Val Gln Arg Tyr Leu Ser Ser Arg Thr Glu Lys 
        275                 280                 285             


Ala Ala Val Leu Ser Cys Tyr Ala Val Phe Pro Phe Gln Gln Val Ser 
    290                 295                 300                 


Leu Cys Val Gly Cys Leu Ile Gly Leu Val Met Phe Ala Tyr Tyr Gln 
305                 310                 315                 320 


Glu Tyr Pro Met Ser Ile Gln Gln Ala Gln Ala Ala Pro Asp Gln Phe 
                325                 330                 335     


Val Leu Tyr Phe Val Met Asp Leu Leu Lys Gly Leu Pro Gly Leu Pro 
            340                 345                 350         


Gly Leu Phe Ile Ala Cys Leu Phe Ser Gly Ser Leu Ser Thr Ile Ser 
        355                 360                 365             


Ser Ala Phe Asn Ser Leu Ala Thr Val Thr Met Glu Asp Leu Ile Arg 
    370                 375                 380                 


Pro Trp Phe Pro Glu Phe Ser Glu Ala Arg Ala Ile Met Leu Ser Arg 
385                 390                 395                 400 


Gly Leu Ala Phe Gly Tyr Gly Leu Leu Cys Leu Gly Met Ala Tyr Ile 
                405                 410                 415     


Ser Ser Gln Met Gly Pro Val Leu Gln Ala Ala Ile Ser Ile Phe Gly 
            420                 425                 430         


Met Val Gly Gly Pro Leu Leu Gly Leu Phe Cys Leu Gly Met Phe Phe 
        435                 440                 445             


Pro Cys Ala Asn Pro Pro Gly Ala Val Val Gly Leu Leu Ala Gly Leu 
    450                 455                 460                 


Val Met Ala Phe Trp Ile Gly Ile Gly Ser Ile Val Thr Ser Met Gly 
465                 470                 475                 480 


Ser Ser Met Pro Pro Ser Pro Ser Asn Gly Ser Ser Phe Ser Leu Pro 
                485                 490                 495     


Thr Asn Leu Thr Val Ala Thr Val Thr Thr Leu Met Pro Leu Thr Thr 
            500                 505                 510         


Phe Ser Lys Pro Thr Gly Leu Gln Arg Phe Tyr Ser Leu Ser Tyr Leu 
        515                 520                 525             


Trp Tyr Ser Ala His Asn Ser Thr Thr Val Ile Val Val Gly Leu Ile 
    530                 535                 540                 


Val Ser Leu Leu Thr Gly Arg Met Arg Gly Arg Ser Leu Asn Pro Ala 
545                 550                 555                 560 


Thr Ile Tyr Pro Val Leu Pro Lys Leu Leu Ser Leu Leu Pro Leu Ser 
                565                 570                 575     


Cys Gln Lys Arg Leu His Cys Arg Ser Tyr Gly Gln Asp His Leu Asp 
            580                 585                 590         


Thr Gly Leu Phe Pro Glu Lys Pro Arg Asn Gly Val Leu Gly Asp Ser 
        595                 600                 605             


Arg Asp Lys Glu Ala Met Ala Leu Asp Gly Thr Ala Tyr Gln Gly Ser 
    610                 615                 620                 


Ser Ser Thr Cys Ile Leu Gln Glu Thr Ser Leu 
625                 630                 635 


<210>  4768
<211>  2223
<212>  PRT
<213>  Homo sapiens

<400>  4768

Met Ala Glu Ser Ala Ser Pro Pro Ser Ser Ser Ala Ala Ala Pro Ala 
1               5                   10                  15      


Ala Glu Pro Gly Val Thr Thr Glu Gln Pro Gly Pro Arg Ser Pro Pro 
            20                  25                  30          


Ser Ser Pro Pro Gly Leu Glu Glu Pro Leu Asp Gly Ala Asp Pro His 
        35                  40                  45              


Val Pro His Pro Asp Leu Ala Pro Ile Ala Phe Phe Cys Leu Arg Gln 
    50                  55                  60                  


Thr Thr Ser Pro Arg Asn Trp Cys Ile Lys Met Val Cys Asn Pro Trp 
65                  70                  75                  80  


Phe Glu Cys Val Ser Met Leu Val Ile Leu Leu Asn Cys Val Thr Leu 
                85                  90                  95      


Gly Met Tyr Gln Pro Cys Asp Asp Met Asp Cys Leu Ser Asp Arg Cys 
            100                 105                 110         


Lys Ile Leu Gln Val Phe Asp Asp Phe Ile Phe Ile Phe Phe Ala Met 
        115                 120                 125             


Glu Met Val Leu Lys Met Val Ala Leu Gly Ile Phe Gly Lys Lys Cys 
    130                 135                 140                 


Tyr Leu Gly Asp Thr Trp Asn Arg Leu Asp Phe Phe Ile Val Met Ala 
145                 150                 155                 160 


Gly Met Val Glu Tyr Ser Leu Asp Leu Gln Asn Ile Asn Leu Ser Ala 
                165                 170                 175     


Ile Arg Thr Val Arg Val Leu Arg Pro Leu Lys Ala Ile Asn Arg Val 
            180                 185                 190         


Pro Ser Met Arg Ile Leu Val Asn Leu Leu Leu Asp Thr Leu Pro Met 
        195                 200                 205             


Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile Phe Gly 
    210                 215                 220                 


Ile Ile Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg Cys Phe 
225                 230                 235                 240 


Leu Glu Glu Asn Phe Thr Ile Gln Gly Asp Val Ala Leu Pro Pro Tyr 
                245                 250                 255     


Tyr Gln Pro Glu Glu Asp Asp Glu Met Pro Phe Ile Cys Ser Leu Ser 
            260                 265                 270         


Gly Asp Asn Gly Ile Met Gly Cys His Glu Ile Pro Pro Leu Lys Glu 
        275                 280                 285             


Gln Gly Arg Glu Cys Cys Leu Ser Lys Asp Asp Val Tyr Asp Phe Gly 
    290                 295                 300                 


Ala Gly Arg Gln Asp Leu Asn Ala Ser Gly Leu Cys Val Asn Trp Asn 
305                 310                 315                 320 


Arg Tyr Tyr Asn Val Cys Arg Thr Gly Ser Ala Asn Pro His Lys Gly 
                325                 330                 335     


Ala Ile Asn Phe Asp Asn Ile Gly Tyr Ala Trp Ile Val Ile Phe Gln 
            340                 345                 350         


Val Ile Thr Leu Glu Gly Trp Val Glu Ile Met Tyr Tyr Val Met Asp 
        355                 360                 365             


Ala His Ser Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val 
    370                 375                 380                 


Gly Ser Phe Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Thr Gln 
385                 390                 395                 400 


Phe Ser Glu Thr Lys Gln Arg Glu His Arg Leu Met Leu Glu Gln Arg 
                405                 410                 415     


Gln Arg Tyr Leu Ser Ser Ser Thr Val Ala Ser Tyr Ala Glu Pro Gly 
            420                 425                 430         


Asp Cys Tyr Glu Glu Ile Phe Gln Tyr Val Cys His Ile Leu Arg Lys 
        435                 440                 445             


Ala Lys Arg Arg Ala Leu Gly Leu Tyr Gln Ala Leu Gln Ser Arg Arg 
    450                 455                 460                 


Gln Ala Leu Gly Pro Glu Ala Pro Ala Pro Ala Lys Pro Gly Pro His 
465                 470                 475                 480 


Ala Lys Glu Pro Arg His Tyr His Gly Lys Thr Lys Gly Gln Gly Asp 
                485                 490                 495     


Glu Gly Arg His Leu Gly Ser Arg His Cys Gln Thr Leu His Gly Pro 
            500                 505                 510         


Ala Ser Pro Gly Asn Asp His Ser Gly Arg Glu Leu Cys Pro Gln His 
        515                 520                 525             


Ser Pro Leu Asp Ala Thr Pro His Thr Leu Val Gln Pro Ile Pro Ala 
    530                 535                 540                 


Thr Leu Ala Ser Asp Pro Ala Ser Cys Pro Cys Cys Gln His Glu Asp 
545                 550                 555                 560 


Gly Arg Arg Pro Ser Gly Leu Gly Ser Thr Asp Ser Gly Gln Glu Gly 
                565                 570                 575     


Ser Gly Ser Gly Ser Ser Ala Gly Gly Glu Asp Glu Ala Asp Gly Asp 
            580                 585                 590         


Gly Ala Arg Ser Ser Glu Asp Gly Ala Ser Ser Glu Leu Gly Lys Glu 
        595                 600                 605             


Glu Glu Glu Glu Glu Gln Ala Asp Gly Ala Val Trp Leu Cys Gly Asp 
    610                 615                 620                 


Val Trp Arg Glu Thr Arg Ala Lys Leu Arg Gly Ile Val Asp Ser Lys 
625                 630                 635                 640 


Tyr Phe Asn Arg Gly Ile Met Met Ala Ile Leu Val Asn Thr Val Ser 
                645                 650                 655     


Met Gly Ile Glu His His Glu Gln Pro Glu Glu Leu Thr Asn Ile Leu 
            660                 665                 670         


Glu Ile Cys Asn Val Val Phe Thr Ser Met Phe Ala Leu Glu Met Ile 
        675                 680                 685             


Leu Lys Leu Ala Ala Phe Gly Leu Phe Asp Tyr Leu Arg Asn Pro Tyr 
    690                 695                 700                 


Asn Ile Phe Asp Ser Ile Ile Val Ile Ile Ser Ile Trp Glu Ile Val 
705                 710                 715                 720 


Gly Gln Ala Asp Gly Gly Leu Ser Val Leu Arg Thr Phe Arg Leu Leu 
                725                 730                 735     


Arg Val Leu Lys Leu Val Arg Phe Met Pro Ala Leu Arg Arg Gln Leu 
            740                 745                 750         


Val Val Leu Met Lys Thr Met Asp Asn Val Ala Thr Phe Cys Met Leu 
        755                 760                 765             


Leu Met Leu Phe Ile Phe Ile Phe Ser Ile Leu Gly Met His Ile Phe 
    770                 775                 780                 


Gly Cys Lys Phe Ser Leu Arg Thr Asp Thr Gly Asp Thr Val Pro Asp 
785                 790                 795                 800 


Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala Ile Val Thr Val Phe Gln 
                805                 810                 815     


Ile Leu Thr Gln Glu Asp Trp Asn Val Val Leu Tyr Asn Gly Met Ala 
            820                 825                 830         


Ser Thr Ser Pro Trp Ala Ser Leu Tyr Phe Val Ala Leu Met Thr Phe 
        835                 840                 845             


Gly Asn Tyr Val Leu Phe Asn Leu Leu Val Ala Ile Leu Val Glu Gly 
    850                 855                 860                 


Phe Gln Ala Glu Gly Asp Ala Asn Arg Ser Tyr Ser Asp Glu Asp Gln 
865                 870                 875                 880 


Ser Ser Ser Asn Ile Glu Glu Phe Asp Lys Leu Gln Glu Gly Leu Asp 
                885                 890                 895     


Ser Ser Gly Asp Pro Lys Leu Cys Pro Ile Pro Met Thr Pro Asn Gly 
            900                 905                 910         


His Leu Asp Pro Ser Leu Pro Leu Gly Gly His Leu Gly Pro Ala Gly 
        915                 920                 925             


Ala Ala Gly Pro Ala Pro Arg Leu Ser Leu Gln Pro Asp Pro Met Leu 
    930                 935                 940                 


Val Ala Leu Gly Ser Arg Lys Ser Ser Val Met Ser Leu Gly Arg Met 
945                 950                 955                 960 


Ser Tyr Asp Gln Arg Ser Leu Ser Ser Ser Arg Ser Ser Tyr Tyr Gly 
                965                 970                 975     


Pro Trp Gly Arg Ser Ala Ala Trp Ala Ser Arg Arg Ser Ser Trp Asn 
            980                 985                 990         


Ser Leu Lys His Lys Pro Pro Ser  Ala Glu His Glu Ser  Leu Leu Ser 
        995                 1000                 1005             


Ala Glu  Arg Gly Gly Gly Ala  Arg Val Cys Glu Val  Ala Ala Asp 
    1010                 1015                 1020             


Glu Gly  Pro Pro Arg Ala Ala  Pro Leu His Thr Pro  His Ala His 
    1025                 1030                 1035             


His Ile  His His Gly Pro His  Leu Ala His Arg His  Arg His His 
    1040                 1045                 1050             


Arg Arg  Thr Leu Ser Leu Asp  Asn Arg Asp Ser Val  Asp Leu Ala 
    1055                 1060                 1065             


Glu Leu  Val Pro Ala Val Gly  Ala His Pro Arg Ala  Ala Trp Arg 
    1070                 1075                 1080             


Ala Ala  Gly Pro Ala Pro Gly  His Glu Asp Cys Asn  Gly Arg Met 
    1085                 1090                 1095             


Pro Ser  Ile Ala Lys Asp Val  Phe Thr Lys Met Gly  Asp Arg Gly 
    1100                 1105                 1110             


Asp Arg  Gly Glu Asp Glu Glu  Glu Ile Asp Tyr Thr  Leu Cys Phe 
    1115                 1120                 1125             


Arg Val  Arg Lys Met Ile Asp  Val Tyr Lys Pro Asp  Trp Cys Glu 
    1130                 1135                 1140             


Val Arg  Glu Asp Trp Ser Val  Tyr Leu Phe Ser Pro  Glu Asn Arg 
    1145                 1150                 1155             


Phe Arg  Val Leu Cys Gln Thr  Ile Ile Ala His Lys  Leu Phe Asp 
    1160                 1165                 1170             


Tyr Val  Val Leu Ala Phe Ile  Phe Leu Asn Cys Ile  Thr Ile Ala 
    1175                 1180                 1185             


Leu Glu  Arg Pro Gln Ile Glu  Ala Gly Ser Thr Glu  Arg Ile Phe 
    1190                 1195                 1200             


Leu Thr  Val Ser Asn Tyr Ile  Phe Thr Ala Ile Phe  Val Gly Glu 
    1205                 1210                 1215             


Met Thr  Leu Lys Val Val Ser  Leu Gly Leu Tyr Phe  Gly Glu Gln 
    1220                 1225                 1230             


Ala Tyr  Leu Arg Ser Ser Trp  Asn Val Leu Asp Gly  Phe Leu Val 
    1235                 1240                 1245             


Phe Val  Ser Ile Ile Asp Ile  Val Val Ser Leu Ala  Ser Ala Gly 
    1250                 1255                 1260             


Gly Ala  Lys Ile Leu Gly Val  Leu Arg Val Leu Arg  Leu Leu Arg 
    1265                 1270                 1275             


Thr Leu  Arg Pro Leu Arg Val  Ile Ser Arg Ala Pro  Gly Leu Lys 
    1280                 1285                 1290             


Leu Val  Val Glu Thr Leu Ile  Ser Ser Leu Lys Pro  Ile Gly Asn 
    1295                 1300                 1305             


Ile Val  Leu Ile Cys Cys Ala  Phe Phe Ile Ile Phe  Gly Ile Leu 
    1310                 1315                 1320             


Gly Val  Gln Leu Phe Lys Gly  Lys Phe Tyr His Cys  Leu Gly Val 
    1325                 1330                 1335             


Asp Thr  Arg Asn Ile Thr Asn  Arg Ser Asp Cys Met  Ala Ala Asn 
    1340                 1345                 1350             


Tyr Arg  Trp Val His His Lys  Tyr Asn Phe Asp Asn  Leu Gly Gln 
    1355                 1360                 1365             


Ala Leu  Met Ser Leu Phe Val  Leu Ala Ser Lys Asp  Gly Trp Val 
    1370                 1375                 1380             


Asn Ile  Met Tyr Asn Gly Leu  Asp Ala Val Ala Val  Asp Gln Gln 
    1385                 1390                 1395             


Pro Val  Thr Asn His Asn Pro  Trp Met Leu Leu Tyr  Phe Ile Ser 
    1400                 1405                 1410             


Phe Leu  Leu Ile Val Ser Phe  Phe Val Leu Asn Met  Phe Val Gly 
    1415                 1420                 1425             


Val Val  Val Glu Asn Phe His  Lys Cys Arg Gln His  Gln Glu Ala 
    1430                 1435                 1440             


Glu Glu  Ala Arg Arg Arg Glu  Glu Lys Arg Leu Arg  Arg Leu Glu 
    1445                 1450                 1455             


Lys Lys  Arg Arg Lys Ala Gln  Arg Leu Pro Tyr Tyr  Ala Thr Tyr 
    1460                 1465                 1470             


Cys His  Thr Arg Leu Leu Ile  His Ser Met Cys Thr  Ser His Tyr 
    1475                 1480                 1485             


Leu Asp  Ile Phe Ile Thr Phe  Ile Ile Cys Leu Asn  Val Val Thr 
    1490                 1495                 1500             


Met Ser  Leu Glu His Tyr Asn  Gln Pro Thr Ser Leu  Glu Thr Ala 
    1505                 1510                 1515             


Leu Lys  Tyr Cys Asn Tyr Met  Phe Thr Thr Val Phe  Val Leu Glu 
    1520                 1525                 1530             


Ala Val  Leu Lys Leu Val Ala  Phe Gly Leu Arg Arg  Phe Phe Lys 
    1535                 1540                 1545             


Asp Arg  Trp Asn Gln Leu Asp  Leu Ala Ile Val Leu  Leu Ser Val 
    1550                 1555                 1560             


Met Gly  Ile Thr Leu Glu Glu  Ile Glu Ile Asn Ala  Ala Leu Pro 
    1565                 1570                 1575             


Ile Asn  Pro Thr Ile Ile Arg  Ile Met Arg Val Leu  Arg Ile Ala 
    1580                 1585                 1590             


Arg Val  Leu Lys Leu Leu Lys  Met Ala Thr Gly Met  Arg Ala Leu 
    1595                 1600                 1605             


Leu Asp  Thr Val Val Gln Ala  Leu Pro Gln Val Gly  Asn Leu Gly 
    1610                 1615                 1620             


Leu Leu  Phe Met Leu Leu Phe  Phe Ile Tyr Ala Ala  Leu Gly Val 
    1625                 1630                 1635             


Glu Leu  Phe Gly Lys Leu Val  Cys Asn Asp Glu Asn  Pro Cys Glu 
    1640                 1645                 1650             


Gly Met  Ser Arg His Ala Thr  Phe Glu Asn Phe Gly  Met Ala Phe 
    1655                 1660                 1665             


Leu Thr  Leu Phe Gln Val Ser  Thr Gly Asp Asn Trp  Asn Gly Ile 
    1670                 1675                 1680             


Met Lys  Asp Thr Leu Arg Asp  Cys Thr His Asp Glu  Arg Ser Cys 
    1685                 1690                 1695             


Leu Ser  Ser Leu Gln Phe Val  Ser Pro Leu Tyr Phe  Val Ser Phe 
    1700                 1705                 1710             


Val Leu  Thr Ala Gln Phe Val  Leu Ile Asn Val Val  Val Ala Val 
    1715                 1720                 1725             


Leu Met  Lys His Leu Asp Asp  Ser Asn Lys Glu Ala  Gln Glu Asp 
    1730                 1735                 1740             


Ala Glu  Met Asp Ala Glu Leu  Glu Leu Glu Met Ala  His Gly Leu 
    1745                 1750                 1755             


Gly Pro  Gly Pro Arg Leu Pro  Thr Gly Ser Pro Gly  Ala Pro Gly 
    1760                 1765                 1770             


Arg Gly  Pro Gly Gly Ala Gly  Gly Gly Gly Asp Thr  Glu Gly Gly 
    1775                 1780                 1785             


Leu Cys  Arg Arg Cys Tyr Ser  Pro Ala Gln Glu Asn  Leu Trp Leu 
    1790                 1795                 1800             


Asp Ser  Val Ser Leu Ile Ile  Lys Asp Ser Leu Glu  Gly Glu Leu 
    1805                 1810                 1815             


Thr Ile  Ile Asp Asn Leu Ser  Gly Ser Ile Phe His  His Tyr Ser 
    1820                 1825                 1830             


Ser Pro  Ala Gly Cys Lys Lys  Cys His His Asp Lys  Gln Glu Val 
    1835                 1840                 1845             


Gln Leu  Ala Glu Thr Glu Ala  Phe Ser Leu Asn Ser  Asp Arg Ser 
    1850                 1855                 1860             


Ser Ser  Ile Leu Leu Gly Asp  Asp Leu Ser Leu Glu  Asp Pro Thr 
    1865                 1870                 1875             


Ala Cys  Pro Pro Gly Arg Lys  Asp Ser Lys Gly Glu  Leu Asp Pro 
    1880                 1885                 1890             


Pro Glu  Pro Met Arg Val Gly  Asp Leu Gly Glu Cys  Phe Phe Pro 
    1895                 1900                 1905             


Leu Ser  Ser Thr Ala Val Ser  Pro Asp Pro Glu Asn  Phe Leu Cys 
    1910                 1915                 1920             


Glu Met  Glu Glu Ile Pro Phe  Asn Pro Val Arg Ser  Trp Leu Lys 
    1925                 1930                 1935             


His Asp  Ser Ser Gln Ala Pro  Pro Ser Pro Phe Ser  Pro Asp Ala 
    1940                 1945                 1950             


Ser Ser  Pro Leu Leu Pro Met  Pro Ala Glu Phe Phe  His Pro Ala 
    1955                 1960                 1965             


Val Ser  Ala Ser Gln Lys Gly  Pro Glu Lys Gly Thr  Gly Thr Gly 
    1970                 1975                 1980             


Thr Leu  Pro Lys Ile Ala Leu  Gln Gly Ser Trp Ala  Ser Leu Arg 
    1985                 1990                 1995             


Ser Pro  Arg Val Asn Cys Thr  Leu Leu Arg Gln Ala  Thr Gly Ser 
    2000                 2005                 2010             


Asp Thr  Ser Leu Asp Ala Ser  Pro Ser Ser Ser Ala  Gly Ser Leu 
    2015                 2020                 2025             


Gln Thr  Thr Leu Glu Asp Ser  Leu Thr Leu Ser Asp  Ser Pro Arg 
    2030                 2035                 2040             


Arg Ala  Leu Gly Pro Pro Ala  Pro Ala Pro Gly Pro  Arg Ala Gly 
    2045                 2050                 2055             


Leu Ser  Pro Ala Ala Arg Arg  Arg Leu Ser Leu Arg  Gly Arg Gly 
    2060                 2065                 2070             


Leu Phe  Ser Leu Arg Gly Leu  Arg Ala His Gln Arg  Ser His Ser 
    2075                 2080                 2085             


Ser Gly  Gly Ser Thr Ser Pro  Gly Cys Thr His His  Asp Ser Met 
    2090                 2095                 2100             


Asp Pro  Ser Asp Glu Glu Gly  Arg Gly Gly Ala Gly  Gly Gly Gly 
    2105                 2110                 2115             


Ala Gly  Ser Glu His Ser Glu  Thr Leu Ser Ser Leu  Ser Leu Thr 
    2120                 2125                 2130             


Ser Leu  Phe Cys Pro Pro Pro  Pro Pro Pro Ala Pro  Gly Leu Thr 
    2135                 2140                 2145             


Pro Ala  Arg Lys Phe Ser Ser  Thr Ser Ser Leu Ala  Ala Pro Gly 
    2150                 2155                 2160             


Arg Pro  His Ala Ala Ala Leu  Ala His Gly Leu Ala  Arg Ser Pro 
    2165                 2170                 2175             


Ser Trp  Ala Ala Asp Arg Ser  Lys Asp Pro Pro Gly  Arg Ala Pro 
    2180                 2185                 2190             


Leu Pro  Met Gly Leu Gly Pro  Leu Ala Pro Pro Pro  Gln Pro Leu 
    2195                 2200                 2205             


Pro Gly  Glu Leu Glu Pro Gly  Asp Ala Ala Ser Lys  Arg Lys Arg 
    2210                 2215                 2220             


<210>  4769
<211>  973
<212>  PRT
<213>  Homo sapiens

<400>  4769

Met Tyr Asn Met Arg Arg Leu Ser Leu Ser Pro Thr Phe Ser Met Gly 
1               5                   10                  15      


Phe His Leu Leu Val Thr Val Ser Leu Leu Phe Ser His Val Asp His 
            20                  25                  30          


Val Ile Ala Glu Thr Glu Met Glu Gly Glu Gly Asn Glu Thr Gly Glu 
        35                  40                  45              


Cys Thr Gly Ser Tyr Tyr Cys Lys Lys Gly Val Ile Leu Pro Ile Trp 
    50                  55                  60                  


Glu Pro Gln Asp Pro Ser Phe Gly Asp Lys Ile Ala Arg Ala Thr Val 
65                  70                  75                  80  


Tyr Phe Val Ala Met Val Tyr Met Phe Leu Gly Val Ser Ile Ile Ala 
                85                  90                  95      


Asp Arg Phe Met Ser Ser Ile Glu Val Ile Thr Ser Gln Glu Lys Glu 
            100                 105                 110         


Ile Thr Ile Lys Lys Pro Asn Gly Glu Thr Thr Lys Thr Thr Val Arg 
        115                 120                 125             


Ile Trp Asn Glu Thr Val Ser Asn Leu Thr Leu Met Ala Leu Gly Ser 
    130                 135                 140                 


Ser Ala Pro Glu Ile Leu Leu Ser Val Ile Glu Val Cys Gly His Asn 
145                 150                 155                 160 


Phe Thr Ala Gly Asp Leu Gly Pro Ser Thr Ile Val Gly Ser Ala Ala 
                165                 170                 175     


Phe Asn Met Phe Ile Ile Ile Ala Leu Cys Val Tyr Val Val Pro Asp 
            180                 185                 190         


Gly Glu Thr Arg Lys Ile Lys His Leu Arg Val Phe Phe Val Thr Ala 
        195                 200                 205             


Ala Trp Ser Ile Phe Ala Tyr Thr Trp Leu Tyr Ile Ile Leu Ser Val 
    210                 215                 220                 


Ile Ser Pro Gly Val Val Glu Val Trp Glu Gly Leu Leu Thr Phe Phe 
225                 230                 235                 240 


Phe Phe Pro Ile Cys Val Val Phe Ala Trp Val Ala Asp Arg Arg Leu 
                245                 250                 255     


Leu Phe Tyr Lys Tyr Val Tyr Lys Arg Tyr Arg Ala Gly Lys Gln Arg 
            260                 265                 270         


Gly Met Ile Ile Glu His Glu Gly Asp Arg Pro Ser Ser Lys Thr Glu 
        275                 280                 285             


Ile Glu Met Asp Gly Lys Val Val Asn Ser His Val Glu Asn Phe Leu 
    290                 295                 300                 


Asp Gly Ala Leu Val Leu Glu Val Asp Glu Arg Asp Gln Asp Asp Glu 
305                 310                 315                 320 


Glu Ala Arg Arg Glu Met Ala Arg Ile Leu Lys Glu Leu Lys Gln Lys 
                325                 330                 335     


His Pro Asp Lys Glu Ile Glu Gln Leu Ile Glu Leu Ala Asn Tyr Gln 
            340                 345                 350         


Val Leu Ser Gln Gln Gln Lys Ser Arg Ala Phe Tyr Arg Ile Gln Ala 
        355                 360                 365             


Thr Arg Leu Met Thr Gly Ala Gly Asn Ile Leu Lys Arg His Ala Ala 
    370                 375                 380                 


Asp Gln Ala Arg Lys Ala Val Ser Met His Glu Val Asn Thr Glu Val 
385                 390                 395                 400 


Thr Glu Asn Asp Pro Val Ser Lys Ile Phe Phe Glu Gln Gly Thr Tyr 
                405                 410                 415     


Gln Cys Leu Glu Asn Cys Gly Thr Val Ala Leu Thr Ile Ile Arg Arg 
            420                 425                 430         


Gly Gly Asp Leu Thr Asn Thr Val Phe Val Asp Phe Arg Thr Glu Asp 
        435                 440                 445             


Gly Thr Ala Asn Ala Gly Ser Asp Tyr Glu Phe Thr Glu Gly Thr Val 
    450                 455                 460                 


Val Phe Lys Pro Gly Asp Thr Gln Lys Glu Ile Arg Val Gly Ile Ile 
465                 470                 475                 480 


Asp Asp Asp Ile Phe Glu Glu Asp Glu Asn Phe Leu Val His Leu Ser 
                485                 490                 495     


Asn Val Lys Val Ser Ser Glu Ala Ser Glu Asp Gly Ile Leu Glu Ala 
            500                 505                 510         


Asn His Val Ser Thr Leu Ala Cys Leu Gly Ser Pro Ser Thr Ala Thr 
        515                 520                 525             


Val Thr Ile Phe Asp Asp Asp His Ala Gly Ile Phe Thr Phe Glu Glu 
    530                 535                 540                 


Pro Val Thr His Val Ser Glu Ser Ile Gly Ile Met Glu Val Lys Val 
545                 550                 555                 560 


Leu Arg Thr Ser Gly Ala Arg Gly Asn Val Ile Val Pro Tyr Lys Thr 
                565                 570                 575     


Ile Glu Gly Thr Ala Arg Gly Gly Gly Glu Asp Phe Glu Asp Thr Cys 
            580                 585                 590         


Gly Glu Leu Glu Phe Gln Asn Asp Glu Ile Val Lys Thr Ile Ser Val 
        595                 600                 605             


Lys Val Ile Asp Asp Glu Glu Tyr Glu Lys Asn Lys Thr Phe Phe Leu 
    610                 615                 620                 


Glu Ile Gly Glu Pro Arg Leu Val Glu Met Ser Glu Lys Lys Ala Leu 
625                 630                 635                 640 


Leu Leu Asn Glu Leu Gly Gly Phe Thr Ile Thr Gly Lys Tyr Leu Phe 
                645                 650                 655     


Gly Gln Pro Val Phe Arg Lys Val His Ala Arg Glu His Pro Ile Leu 
            660                 665                 670         


Ser Thr Val Ile Thr Ile Ala Asp Glu Tyr Asp Asp Lys Gln Pro Leu 
        675                 680                 685             


Thr Ser Lys Glu Glu Glu Glu Arg Arg Ile Ala Glu Met Gly Arg Pro 
    690                 695                 700                 


Ile Leu Gly Glu His Thr Lys Leu Glu Val Ile Ile Glu Glu Ser Tyr 
705                 710                 715                 720 


Glu Phe Lys Ser Thr Val Asp Lys Leu Ile Lys Lys Thr Asn Leu Ala 
                725                 730                 735     


Leu Val Val Gly Thr Asn Ser Trp Arg Glu Gln Phe Ile Glu Ala Ile 
            740                 745                 750         


Thr Val Ser Ala Gly Glu Asp Asp Asp Asp Asp Glu Cys Gly Glu Glu 
        755                 760                 765             


Lys Leu Pro Ser Cys Phe Asp Tyr Val Met His Phe Leu Thr Val Phe 
    770                 775                 780                 


Trp Lys Val Leu Phe Ala Phe Val Pro Pro Thr Glu Tyr Trp Asn Gly 
785                 790                 795                 800 


Trp Ala Cys Phe Ile Val Ser Ile Leu Met Ile Gly Leu Leu Thr Ala 
                805                 810                 815     


Phe Ile Gly Asp Leu Ala Ser His Phe Gly Cys Thr Ile Gly Leu Lys 
            820                 825                 830         


Asp Ser Val Thr Ala Val Val Phe Val Ala Leu Gly Thr Ser Val Pro 
        835                 840                 845             


Asp Thr Phe Ala Ser Lys Val Ala Ala Thr Gln Asp Gln Tyr Ala Asp 
    850                 855                 860                 


Ala Ser Ile Gly Asn Val Thr Gly Ser Asn Ala Val Asn Val Phe Leu 
865                 870                 875                 880 


Gly Ile Gly Val Ala Trp Ser Ile Ala Ala Ile Tyr His Ala Ala Asn 
                885                 890                 895     


Gly Glu Gln Phe Lys Val Ser Pro Gly Thr Leu Ala Phe Ser Val Thr 
            900                 905                 910         


Leu Phe Thr Ile Phe Ala Phe Ile Asn Val Gly Val Leu Leu Tyr Arg 
        915                 920                 925             


Arg Arg Pro Glu Ile Gly Gly Glu Leu Gly Gly Pro Arg Thr Ala Lys 
    930                 935                 940                 


Leu Leu Thr Ser Cys Leu Phe Val Leu Leu Trp Leu Leu Tyr Ile Phe 
945                 950                 955                 960 


Phe Ser Ser Leu Glu Ala Tyr Cys His Ile Lys Gly Phe 
                965                 970             


<210>  4770
<211>  2353
<212>  PRT
<213>  Homo sapiens

<400>  4770

Met Thr Glu Gly Ala Arg Ala Ala Asp Glu Val Arg Val Pro Leu Gly 
1               5                   10                  15      


Ala Pro Pro Pro Gly Pro Ala Ala Leu Val Gly Ala Ser Pro Glu Ser 
            20                  25                  30          


Pro Gly Ala Pro Gly Arg Glu Ala Glu Arg Gly Ser Glu Leu Gly Val 
        35                  40                  45              


Ser Pro Ser Glu Ser Pro Ala Ala Glu Arg Gly Ala Glu Leu Gly Ala 
    50                  55                  60                  


Asp Glu Glu Gln Arg Val Pro Tyr Pro Ala Leu Ala Ala Thr Val Phe 
65                  70                  75                  80  


Phe Cys Leu Gly Gln Thr Thr Arg Pro Arg Ser Trp Cys Leu Arg Leu 
                85                  90                  95      


Val Cys Asn Pro Trp Phe Glu His Val Ser Met Leu Val Ile Met Leu 
            100                 105                 110         


Asn Cys Val Thr Leu Gly Met Phe Arg Pro Cys Glu Asp Val Glu Cys 
        115                 120                 125             


Gly Ser Glu Arg Cys Asn Ile Leu Glu Ala Phe Asp Ala Phe Ile Phe 
    130                 135                 140                 


Ala Phe Phe Ala Val Glu Met Val Ile Lys Met Val Ala Leu Gly Leu 
145                 150                 155                 160 


Phe Gly Gln Lys Cys Tyr Leu Gly Asp Thr Trp Asn Arg Leu Asp Phe 
                165                 170                 175     


Phe Ile Val Val Ala Gly Met Met Glu Tyr Ser Leu Asp Gly His Asn 
            180                 185                 190         


Val Ser Leu Ser Ala Ile Arg Thr Val Arg Val Leu Arg Pro Leu Arg 
        195                 200                 205             


Ala Ile Asn Arg Val Pro Ser Met Arg Ile Leu Val Thr Leu Leu Leu 
    210                 215                 220                 


Asp Thr Leu Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val 
225                 230                 235                 240 


Phe Phe Ile Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu 
                245                 250                 255     


Arg Asn Arg Cys Phe Leu Asp Ser Ala Phe Val Arg Asn Asn Asn Leu 
            260                 265                 270         


Thr Phe Leu Arg Pro Tyr Tyr Gln Thr Glu Glu Gly Glu Glu Asn Pro 
        275                 280                 285             


Phe Ile Cys Ser Ser Arg Arg Asp Asn Gly Met Gln Lys Cys Ser His 
    290                 295                 300                 


Ile Pro Gly Arg Arg Glu Leu Arg Met Pro Cys Thr Leu Gly Trp Glu 
305                 310                 315                 320 


Ala Tyr Thr Gln Pro Gln Ala Glu Gly Val Gly Ala Ala Arg Asn Ala 
                325                 330                 335     


Cys Ile Asn Trp Asn Gln Tyr Tyr Asn Val Cys Arg Ser Gly Asp Ser 
            340                 345                 350         


Asn Pro His Asn Gly Ala Ile Asn Phe Asp Asn Ile Gly Tyr Ala Trp 
        355                 360                 365             


Ile Ala Ile Phe Gln Val Ile Thr Leu Glu Gly Trp Val Asp Ile Met 
    370                 375                 380                 


Tyr Tyr Val Met Asp Ala His Ser Phe Tyr Asn Phe Ile Tyr Phe Ile 
385                 390                 395                 400 


Leu Leu Ile Ile Val Gly Ser Phe Phe Met Ile Asn Leu Cys Leu Val 
                405                 410                 415     


Val Ile Ala Thr Gln Phe Ser Glu Thr Lys Gln Arg Glu Ser Gln Leu 
            420                 425                 430         


Met Arg Glu Gln Arg Ala Arg His Leu Ser Asn Asp Ser Thr Leu Ala 
        435                 440                 445             


Ser Phe Ser Glu Pro Gly Ser Cys Tyr Glu Glu Leu Leu Lys Tyr Val 
    450                 455                 460                 


Gly His Ile Phe Arg Lys Val Lys Arg Arg Ser Leu Arg Leu Tyr Ala 
465                 470                 475                 480 


Arg Trp Gln Ser Arg Trp Arg Lys Lys Val Asp Pro Ser Ala Val Gln 
                485                 490                 495     


Gly Gln Gly Pro Gly His Arg Gln Arg Arg Ala Gly Arg His Thr Ala 
            500                 505                 510         


Ser Val His His Leu Val Tyr His His His His His His His His His 
        515                 520                 525             


Tyr His Phe Ser His Gly Ser Pro Arg Arg Pro Gly Pro Glu Pro Gly 
    530                 535                 540                 


Ala Cys Asp Thr Arg Leu Val Arg Ala Gly Ala Pro Pro Ser Pro Pro 
545                 550                 555                 560 


Ser Pro Gly Arg Gly Pro Pro Asp Ala Glu Ser Val His Ser Ile Tyr 
                565                 570                 575     


His Ala Asp Cys His Ile Glu Gly Pro Gln Glu Arg Ala Arg Val Ala 
            580                 585                 590         


His Ala Ala Ala Thr Ala Ala Ala Ser Leu Arg Leu Ala Thr Gly Leu 
        595                 600                 605             


Gly Thr Met Asn Tyr Pro Thr Ile Leu Pro Ser Gly Val Gly Ser Gly 
    610                 615                 620                 


Lys Gly Ser Thr Ser Pro Gly Pro Lys Gly Lys Trp Ala Gly Gly Pro 
625                 630                 635                 640 


Pro Gly Thr Gly Gly His Gly Pro Leu Ser Leu Asn Ser Pro Asp Pro 
                645                 650                 655     


Tyr Glu Lys Ile Pro His Val Val Gly Glu His Gly Leu Gly Gln Ala 
            660                 665                 670         


Pro Gly His Leu Ser Gly Leu Ser Val Pro Cys Pro Leu Pro Ser Pro 
        675                 680                 685             


Pro Ala Gly Thr Leu Thr Cys Glu Leu Lys Ser Cys Pro Tyr Cys Thr 
    690                 695                 700                 


Arg Ala Leu Glu Asp Pro Glu Gly Glu Leu Ser Gly Ser Glu Ser Gly 
705                 710                 715                 720 


Asp Ser Asp Gly Arg Gly Val Tyr Glu Phe Thr Gln Asp Val Arg His 
                725                 730                 735     


Gly Asp Arg Trp Asp Pro Thr Arg Pro Pro Arg Ala Thr Asp Thr Pro 
            740                 745                 750         


Gly Pro Gly Pro Gly Ser Pro Gln Arg Arg Ala Gln Gln Arg Ala Ala 
        755                 760                 765             


Pro Gly Glu Pro Gly Trp Met Gly Arg Leu Trp Val Thr Phe Ser Gly 
    770                 775                 780                 


Lys Leu Arg Arg Ile Val Asp Ser Lys Tyr Phe Ser Arg Gly Ile Met 
785                 790                 795                 800 


Met Ala Ile Leu Val Asn Thr Leu Ser Met Gly Val Glu Tyr His Glu 
                805                 810                 815     


Gln Pro Glu Glu Leu Thr Asn Ala Leu Glu Ile Ser Asn Ile Val Phe 
            820                 825                 830         


Thr Ser Met Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Ala Cys Gly 
        835                 840                 845             


Pro Leu Gly Tyr Ile Arg Asn Pro Tyr Asn Ile Phe Asp Gly Ile Ile 
    850                 855                 860                 


Val Val Ile Ser Val Trp Glu Ile Val Gly Gln Ala Asp Gly Gly Leu 
865                 870                 875                 880 


Ser Val Leu Arg Thr Phe Arg Leu Leu Arg Val Leu Lys Leu Val Arg 
                885                 890                 895     


Phe Leu Pro Ala Leu Arg Arg Gln Leu Val Val Leu Val Lys Thr Met 
            900                 905                 910         


Asp Asn Val Ala Thr Phe Cys Thr Leu Leu Met Leu Phe Ile Phe Ile 
        915                 920                 925             


Phe Ser Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ser Leu Lys 
    930                 935                 940                 


Thr Asp Thr Gly Asp Thr Val Pro Asp Arg Lys Asn Phe Asp Ser Leu 
945                 950                 955                 960 


Leu Trp Ala Ile Val Thr Val Phe Gln Ile Leu Thr Gln Glu Asp Trp 
                965                 970                 975     


Asn Val Val Leu Tyr Asn Gly Met Ala Ser Thr Ser Ser Trp Ala Ala 
            980                 985                 990         


Leu Tyr Phe Val Ala Leu Met Thr  Phe Gly Asn Tyr Val  Leu Phe Asn 
        995                 1000                 1005             


Leu Leu  Val Ala Ile Leu Val  Glu Gly Phe Gln Ala  Glu Gly Asp 
    1010                 1015                 1020             


Ala Asn  Arg Ser Asp Thr Asp  Glu Asp Lys Thr Ser  Val His Phe 
    1025                 1030                 1035             


Glu Glu  Asp Phe His Lys Leu  Arg Glu Leu Gln Thr  Thr Glu Leu 
    1040                 1045                 1050             


Lys Met  Cys Ser Leu Ala Val  Thr Pro Asn Gly His  Leu Glu Gly 
    1055                 1060                 1065             


Arg Gly  Ser Leu Ser Pro Pro  Leu Ile Met Cys Thr  Ala Ala Thr 
    1070                 1075                 1080             


Pro Met  Pro Thr Pro Lys Ser  Ser Pro Phe Leu Asp  Ala Ala Pro 
    1085                 1090                 1095             


Ser Leu  Pro Asp Ser Arg Arg  Gly Ser Ser Ser Ser  Gly Asp Pro 
    1100                 1105                 1110             


Pro Leu  Gly Asp Gln Lys Pro  Pro Ala Ser Leu Arg  Ser Ser Pro 
    1115                 1120                 1125             


Cys Ala  Pro Trp Gly Pro Ser  Gly Ala Trp Ser Ser  Arg Arg Ser 
    1130                 1135                 1140             


Ser Trp  Ser Ser Leu Gly Arg  Ala Pro Ser Leu Lys  Arg Arg Gly 
    1145                 1150                 1155             


Gln Cys  Gly Glu Arg Glu Ser  Leu Leu Ser Gly Glu  Gly Lys Gly 
    1160                 1165                 1170             


Ser Thr  Asp Asp Glu Ala Glu  Asp Gly Arg Ala Ala  Pro Gly Pro 
    1175                 1180                 1185             


Arg Ala  Thr Pro Leu Arg Arg  Ala Glu Ser Leu Asp  Pro Arg Pro 
    1190                 1195                 1200             


Leu Arg  Pro Ala Ala Leu Pro  Pro Thr Lys Cys Arg  Asp Arg Asp 
    1205                 1210                 1215             


Gly Gln  Val Val Ala Leu Pro  Ser Asp Phe Phe Leu  Arg Ile Asp 
    1220                 1225                 1230             


Ser His  Arg Glu Asp Ala Ala  Glu Leu Asp Asp Asp  Ser Glu Asp 
    1235                 1240                 1245             


Ser Cys  Cys Leu Arg Leu His  Lys Val Leu Glu Pro  Tyr Lys Pro 
    1250                 1255                 1260             


Gln Trp  Cys Arg Ser Arg Glu  Ala Trp Ala Leu Tyr  Leu Phe Ser 
    1265                 1270                 1275             


Pro Gln  Asn Arg Phe Arg Val  Ser Cys Gln Lys Val  Ile Thr His 
    1280                 1285                 1290             


Lys Met  Phe Asp His Val Val  Leu Val Phe Ile Phe  Leu Asn Cys 
    1295                 1300                 1305             


Val Thr  Ile Ala Leu Glu Arg  Pro Asp Ile Asp Pro  Gly Ser Thr 
    1310                 1315                 1320             


Glu Arg  Val Phe Leu Ser Val  Ser Asn Tyr Ile Phe  Thr Ala Ile 
    1325                 1330                 1335             


Phe Val  Ala Glu Met Met Val  Lys Val Val Ala Leu  Gly Leu Leu 
    1340                 1345                 1350             


Ser Gly  Glu His Ala Tyr Leu  Gln Ser Ser Trp Asn  Leu Leu Asp 
    1355                 1360                 1365             


Gly Leu  Leu Val Leu Val Ser  Leu Val Asp Ile Val  Val Ala Met 
    1370                 1375                 1380             


Ala Ser  Ala Gly Gly Ala Lys  Ile Leu Gly Val Leu  Arg Val Leu 
    1385                 1390                 1395             


Arg Leu  Leu Arg Thr Leu Arg  Pro Leu Arg Val Ile  Ser Arg Ala 
    1400                 1405                 1410             


Pro Gly  Leu Lys Leu Val Val  Glu Thr Leu Ile Ser  Ser Leu Arg 
    1415                 1420                 1425             


Pro Ile  Gly Asn Ile Val Leu  Ile Cys Cys Ala Phe  Phe Ile Ile 
    1430                 1435                 1440             


Phe Gly  Ile Leu Gly Val Gln  Leu Phe Lys Gly Lys  Phe Tyr Tyr 
    1445                 1450                 1455             


Cys Glu  Gly Pro Asp Thr Arg  Asn Ile Ser Thr Lys  Ala Gln Cys 
    1460                 1465                 1470             


Arg Ala  Ala His Tyr Arg Trp  Val Arg Arg Lys Tyr  Asn Phe Asp 
    1475                 1480                 1485             


Asn Leu  Gly Gln Ala Leu Met  Ser Leu Phe Val Leu  Ser Ser Lys 
    1490                 1495                 1500             


Asp Gly  Trp Val Asn Ile Met  Tyr Asp Gly Leu Asp  Ala Val Gly 
    1505                 1510                 1515             


Val Asp  Gln Gln Pro Val Gln  Asn His Asn Pro Trp  Met Leu Leu 
    1520                 1525                 1530             


Tyr Phe  Ile Ser Phe Leu Leu  Ile Val Ser Phe Phe  Val Leu Asn 
    1535                 1540                 1545             


Met Phe  Val Gly Val Val Val  Glu Asn Phe His Lys  Cys Arg Gln 
    1550                 1555                 1560             


His Gln  Glu Ala Glu Glu Ala  Arg Arg Arg Glu Glu  Lys Arg Leu 
    1565                 1570                 1575             


Arg Arg  Leu Glu Arg Arg Arg  Arg Ser Thr Phe Pro  Ser Pro Glu 
    1580                 1585                 1590             


Ala Gln  Arg Arg Pro Tyr Tyr  Ala Asp Tyr Ser Pro  Thr Arg Arg 
    1595                 1600                 1605             


Ser Ile  His Ser Leu Cys Thr  Ser His Tyr Leu Asp  Leu Phe Ile 
    1610                 1615                 1620             


Thr Phe  Ile Ile Cys Val Asn  Val Ile Thr Met Ser  Met Glu His 
    1625                 1630                 1635             


Tyr Asn  Gln Pro Lys Ser Leu  Asp Glu Ala Leu Lys  Tyr Cys Asn 
    1640                 1645                 1650             


Tyr Val  Phe Thr Ile Val Phe  Val Phe Glu Ala Ala  Leu Lys Leu 
    1655                 1660                 1665             


Val Ala  Phe Gly Phe Arg Arg  Phe Phe Lys Asp Arg  Trp Asn Gln 
    1670                 1675                 1680             


Leu Asp  Leu Ala Ile Val Leu  Leu Ser Leu Met Gly  Ile Thr Leu 
    1685                 1690                 1695             


Glu Glu  Ile Glu Met Ser Ala  Ala Leu Pro Ile Asn  Pro Thr Ile 
    1700                 1705                 1710             


Ile Arg  Ile Met Arg Val Leu  Arg Ile Ala Arg Val  Leu Lys Leu 
    1715                 1720                 1725             


Leu Lys  Met Ala Thr Gly Met  Arg Ala Leu Leu Asp  Thr Val Val 
    1730                 1735                 1740             


Gln Ala  Leu Pro Gln Val Gly  Asn Leu Gly Leu Leu  Phe Met Leu 
    1745                 1750                 1755             


Leu Phe  Phe Ile Tyr Ala Ala  Leu Gly Val Glu Leu  Phe Gly Arg 
    1760                 1765                 1770             


Leu Glu  Cys Ser Glu Asp Asn  Pro Cys Glu Gly Leu  Ser Arg His 
    1775                 1780                 1785             


Ala Thr  Phe Ser Asn Phe Gly  Met Ala Phe Leu Thr  Leu Phe Arg 
    1790                 1795                 1800             


Val Ser  Thr Gly Asp Asn Trp  Asn Gly Ile Met Lys  Asp Thr Leu 
    1805                 1810                 1815             


Arg Glu  Cys Ser Arg Glu Asp  Lys His Cys Leu Ser  Tyr Leu Pro 
    1820                 1825                 1830             


Ala Leu  Ser Pro Val Tyr Phe  Val Thr Phe Val Leu  Val Ala Gln 
    1835                 1840                 1845             


Phe Val  Leu Val Asn Val Val  Val Ala Val Leu Met  Lys His Leu 
    1850                 1855                 1860             


Glu Glu  Ser Asn Lys Glu Ala  Arg Glu Asp Ala Glu  Leu Asp Ala 
    1865                 1870                 1875             


Glu Ile  Glu Leu Glu Met Ala  Gln Gly Pro Gly Ser  Ala Arg Arg 
    1880                 1885                 1890             


Val Asp  Ala Asp Arg Pro Pro  Leu Pro Gln Glu Ser  Pro Gly Ala 
    1895                 1900                 1905             


Arg Asp  Ala Pro Asn Leu Val  Ala Arg Lys Val Ser  Val Ser Arg 
    1910                 1915                 1920             


Met Leu  Ser Leu Pro Asn Asp  Ser Tyr Met Phe Arg  Pro Val Val 
    1925                 1930                 1935             


Pro Ala  Ser Ala Pro His Pro  Arg Pro Leu Gln Glu  Val Glu Met 
    1940                 1945                 1950             


Glu Thr  Tyr Gly Ala Gly Thr  Pro Leu Gly Ser Val  Ala Ser Val 
    1955                 1960                 1965             


His Ser  Pro Pro Ala Glu Ser  Cys Ala Ser Leu Gln  Ile Pro Leu 
    1970                 1975                 1980             


Ala Val  Ser Ser Pro Ala Arg  Ser Gly Glu Pro Leu  His Ala Leu 
    1985                 1990                 1995             


Ser Pro  Arg Gly Thr Ala Arg  Ser Pro Ser Leu Ser  Arg Leu Leu 
    2000                 2005                 2010             


Cys Arg  Gln Glu Ala Val His  Thr Asp Ser Leu Glu  Gly Lys Ile 
    2015                 2020                 2025             


Asp Ser  Pro Arg Asp Thr Leu  Asp Pro Ala Glu Pro  Gly Glu Lys 
    2030                 2035                 2040             


Thr Pro  Val Arg Pro Val Thr  Gln Gly Gly Ser Leu  Gln Ser Pro 
    2045                 2050                 2055             


Pro Arg  Ser Pro Arg Pro Ala  Ser Val Arg Thr Arg  Lys His Thr 
    2060                 2065                 2070             


Phe Gly  Gln Arg Cys Val Ser  Ser Arg Pro Ala Ala  Pro Gly Gly 
    2075                 2080                 2085             


Glu Glu  Ala Glu Ala Ser Asp  Pro Ala Asp Glu Glu  Val Ser His 
    2090                 2095                 2100             


Ile Thr  Ser Ser Ala Cys Pro  Trp Gln Pro Thr Ala  Glu Pro His 
    2105                 2110                 2115             


Gly Pro  Glu Ala Ser Pro Val  Ala Gly Gly Glu Arg  Asp Leu Arg 
    2120                 2125                 2130             


Arg Leu  Tyr Ser Val Asp Ala  Gln Gly Phe Leu Asp  Lys Pro Gly 
    2135                 2140                 2145             


Arg Ala  Asp Glu Gln Trp Arg  Pro Ser Ala Glu Leu  Gly Ser Gly 
    2150                 2155                 2160             


Glu Pro  Gly Glu Ala Lys Ala  Trp Gly Pro Glu Ala  Glu Pro Ala 
    2165                 2170                 2175             


Leu Gly  Ala Arg Arg Lys Lys  Lys Met Ser Pro Pro  Cys Ile Ser 
    2180                 2185                 2190             


Val Glu  Pro Pro Ala Glu Asp  Glu Gly Ser Ala Arg  Pro Ser Ala 
    2195                 2200                 2205             


Ala Glu  Gly Gly Ser Thr Thr  Leu Arg Arg Arg Thr  Pro Ser Cys 
    2210                 2215                 2220             


Glu Ala  Thr Pro His Arg Asp  Ser Leu Glu Pro Thr  Glu Gly Ser 
    2225                 2230                 2235             


Gly Ala  Gly Gly Asp Pro Ala  Ala Lys Gly Glu Arg  Trp Gly Gln 
    2240                 2245                 2250             


Ala Ser  Cys Arg Ala Glu His  Leu Thr Val Pro Ser  Phe Ala Phe 
    2255                 2260                 2265             


Glu Pro  Leu Asp Leu Gly Val  Pro Ser Gly Asp Pro  Phe Leu Asp 
    2270                 2275                 2280             


Gly Ser  His Ser Val Thr Pro  Glu Ser Arg Ala Ser  Ser Ser Gly 
    2285                 2290                 2295             


Ala Ile  Val Pro Leu Glu Pro  Pro Glu Ser Glu Pro  Pro Met Pro 
    2300                 2305                 2310             


Val Gly  Asp Pro Pro Glu Lys  Arg Arg Gly Leu Tyr  Leu Thr Val 
    2315                 2320                 2325             


Pro Gln  Cys Pro Leu Glu Lys  Pro Gly Ser Pro Ser  Ala Thr Pro 
    2330                 2335                 2340             


Ala Pro  Gly Gly Gly Ala Asp  Asp Pro Val 
    2345                 2350             


<210>  4771
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  4771

Met Ala Asn Ala Gly Leu Gln Leu Leu Gly Phe Ile Leu Ala Phe Leu 
1               5                   10                  15      


Gly Trp Ile Gly Ala Ile Val Ser Thr Ala Leu Pro Gln Trp Arg Ile 
            20                  25                  30          


Tyr Ser Tyr Ala Gly Asp Asn Ile Val Thr Ala Gln Ala Met Tyr Glu 
        35                  40                  45              


Gly Leu Trp Met Ser Cys Val Ser Gln Ser Thr Gly Gln Ile Gln Cys 
    50                  55                  60                  


Lys Val Phe Asp Ser Leu Leu Asn Leu Ser Ser Thr Leu Gln Ala Thr 
65                  70                  75                  80  


Arg Ala Leu Met Val Val Gly Ile Leu Leu Gly Val Ile Ala Ile Phe 
                85                  90                  95      


Val Ala Thr Val Gly Met Lys Cys Met Lys Cys Leu Glu Asp Asp Glu 
            100                 105                 110         


Val Gln Lys Met Arg Met Ala Val Ile Gly Gly Ala Ile Phe Leu Leu 
        115                 120                 125             


Ala Gly Leu Ala Ile Leu Val Ala Thr Ala Trp Tyr Gly Asn Arg Ile 
    130                 135                 140                 


Val Gln Glu Phe Tyr Asp Pro Met Thr Pro Val Asn Ala Arg Tyr Glu 
145                 150                 155                 160 


Phe Gly Gln Ala Leu Phe Thr Gly Trp Ala Ala Ala Ser Leu Cys Leu 
                165                 170                 175     


Leu Gly Gly Ala Leu Leu Cys Cys Ser Cys Pro Arg Lys Thr Thr Ser 
            180                 185                 190         


Tyr Pro Thr Pro Arg Pro Tyr Pro Lys Pro Ala Pro Ser Ser Gly Lys 
        195                 200                 205             


Asp Tyr Val 
    210     


<210>  4772
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  4772

Met Ala Gln Leu Cys Gly Leu Arg Arg Ser Arg Ala Phe Leu Ala Leu 
1               5                   10                  15      


Leu Gly Ser Leu Leu Leu Ser Gly Val Leu Ala Ala Asp Arg Glu Arg 
            20                  25                  30          


Ser Ile His Asp Phe Cys Leu Val Ser Lys Val Val Gly Arg Cys Arg 
        35                  40                  45              


Ala Ser Met Pro Arg Trp Trp Tyr Asn Val Thr Asp Gly Ser Cys Gln 
    50                  55                  60                  


Leu Phe Val Tyr Gly Gly Cys Asp Gly Asn Ser Asn Asn Tyr Leu Thr 
65                  70                  75                  80  


Lys Glu Glu Cys Leu Lys Lys Cys Ala Thr Val Thr Glu Asn Ala Thr 
                85                  90                  95      


Gly Asp Leu Ala Thr Ser Arg Asn Ala Ala Asp Ser Ser Val Pro Ser 
            100                 105                 110         


Ala Pro Arg Arg Gln Asp Ser Glu Asp His Ser Ser Asp Met Phe Asn 
        115                 120                 125             


Tyr Glu Glu Tyr Cys Thr Ala Asn Ala Val Thr Gly Pro Cys Arg Ala 
    130                 135                 140                 


Ser Phe Pro Arg Trp Tyr Phe Asp Val Glu Arg Asn Ser Cys Asn Asn 
145                 150                 155                 160 


Phe Ile Tyr Gly Gly Cys Arg Gly Asn Lys Asn Ser Tyr Arg Ser Glu 
                165                 170                 175     


Glu Ala Cys Met Leu Arg Cys Phe Arg Gln Gln Glu Asn Pro Pro Leu 
            180                 185                 190         


Pro Leu Gly Ser Lys Val Val Val Leu Ala Gly Leu Phe Val Met Val 
        195                 200                 205             


Leu Ile Leu Phe Leu Gly Ala Ser Met Val Tyr Leu Ile Arg Val Ala 
    210                 215                 220                 


Arg Arg Asn Gln Glu Arg Ala Leu Arg Thr Val Trp Ser Ser Gly Asp 
225                 230                 235                 240 


Asp Lys Glu Gln Leu Val Lys Asn Thr Tyr Val Leu 
                245                 250         


<210>  4773
<211>  1796
<212>  PRT
<213>  Homo sapiens

<400>  4773

Met Lys Ile Phe Gln Arg Lys Met Arg Tyr Trp Leu Leu Pro Pro Phe 
1               5                   10                  15      


Leu Ala Ile Val Tyr Phe Cys Thr Ile Val Gln Gly Gln Val Ala Pro 
            20                  25                  30          


Pro Thr Arg Leu Arg Tyr Asn Val Ile Ser His Asp Ser Ile Gln Ile 
        35                  40                  45              


Ser Trp Lys Ala Pro Arg Gly Lys Phe Gly Gly Tyr Lys Leu Leu Val 
    50                  55                  60                  


Thr Pro Thr Ser Gly Gly Lys Thr Asn Gln Leu Asn Leu Gln Asn Thr 
65                  70                  75                  80  


Ala Thr Lys Ala Ile Ile Gln Gly Leu Met Pro Asp Gln Asn Tyr Thr 
                85                  90                  95      


Val Gln Ile Ile Ala Tyr Asn Lys Asp Lys Glu Ser Lys Pro Ala Gln 
            100                 105                 110         


Gly Gln Phe Arg Ile Lys Asp Leu Glu Lys Arg Lys Asp Pro Lys Pro 
        115                 120                 125             


Arg Val Lys Val Val Asp Arg Gly Asn Gly Ser Arg Pro Ser Ser Pro 
    130                 135                 140                 


Glu Glu Val Lys Phe Val Cys Gln Thr Pro Ala Ile Ala Asp Ile Val 
145                 150                 155                 160 


Ile Leu Val Asp Gly Ser Trp Ser Ile Gly Arg Phe Asn Phe Arg Leu 
                165                 170                 175     


Val Arg His Phe Leu Glu Asn Leu Val Thr Ala Phe Asp Val Gly Ser 
            180                 185                 190         


Glu Lys Thr Arg Ile Gly Leu Ala Gln Tyr Ser Gly Asp Pro Arg Ile 
        195                 200                 205             


Glu Trp His Leu Asn Ala Phe Ser Thr Lys Asp Glu Val Ile Glu Ala 
    210                 215                 220                 


Val Arg Asn Leu Pro Tyr Lys Gly Gly Asn Thr Leu Thr Gly Leu Ala 
225                 230                 235                 240 


Leu Asn Tyr Ile Phe Glu Asn Ser Phe Lys Pro Glu Ala Gly Ser Arg 
                245                 250                 255     


Thr Gly Val Ser Lys Ile Gly Ile Leu Ile Thr Asp Gly Lys Ser Gln 
            260                 265                 270         


Asp Asp Ile Ile Pro Pro Ser Arg Asn Leu Arg Glu Ser Gly Val Glu 
        275                 280                 285             


Leu Phe Ala Ile Gly Val Lys Asn Ala Asp Val Asn Glu Leu Gln Glu 
    290                 295                 300                 


Ile Ala Ser Glu Pro Asp Ser Thr His Val Tyr Asn Val Ala Glu Phe 
305                 310                 315                 320 


Asp Leu Met His Thr Val Val Glu Ser Leu Thr Arg Thr Leu Cys Ser 
                325                 330                 335     


Arg Val Glu Glu Gln Asp Arg Glu Ile Lys Ala Ser Ala His Ala Ile 
            340                 345                 350         


Thr Gly Pro Pro Thr Glu Leu Ile Thr Ser Glu Val Thr Ala Arg Ser 
        355                 360                 365             


Phe Met Val Asn Trp Thr His Ala Pro Gly Asn Val Glu Lys Tyr Arg 
    370                 375                 380                 


Val Val Tyr Tyr Pro Thr Arg Gly Gly Lys Pro Asp Glu Val Val Val 
385                 390                 395                 400 


Asp Gly Thr Val Ser Ser Thr Val Leu Lys Asn Leu Met Ser Leu Thr 
                405                 410                 415     


Glu Tyr Gln Ile Ala Val Phe Ala Ile Tyr Ala His Thr Ala Ser Glu 
            420                 425                 430         


Gly Leu Arg Gly Thr Glu Thr Thr Leu Ala Leu Pro Met Ala Ser Asp 
        435                 440                 445             


Leu Leu Leu Tyr Asp Val Thr Glu Asn Ser Met Arg Val Lys Trp Asp 
    450                 455                 460                 


Ala Val Pro Gly Ala Ser Gly Tyr Leu Ile Leu Tyr Ala Pro Leu Thr 
465                 470                 475                 480 


Glu Gly Leu Ala Gly Asp Glu Lys Glu Met Lys Ile Gly Glu Thr His 
                485                 490                 495     


Thr Asp Ile Glu Leu Ser Gly Leu Leu Pro Asn Thr Glu Tyr Thr Val 
            500                 505                 510         


Thr Val Tyr Ala Met Phe Gly Glu Glu Ala Ser Asp Pro Val Thr Gly 
        515                 520                 525             


Gln Glu Thr Thr Leu Ala Leu Ser Pro Pro Arg Asn Leu Arg Ile Ser 
    530                 535                 540                 


Asn Val Gly Ser Asn Ser Ala Arg Leu Thr Trp Asp Pro Thr Ser Arg 
545                 550                 555                 560 


Gln Ile Asn Gly Tyr Arg Ile Val Tyr Asn Asn Ala Asp Gly Thr Glu 
                565                 570                 575     


Ile Asn Glu Val Glu Val Asp Pro Ile Thr Thr Phe Pro Leu Lys Gly 
            580                 585                 590         


Leu Thr Pro Leu Thr Glu Tyr Thr Ile Ala Ile Phe Ser Ile Tyr Asp 
        595                 600                 605             


Glu Gly Gln Ser Glu Pro Leu Thr Gly Val Phe Thr Thr Glu Glu Val 
    610                 615                 620                 


Pro Ala Gln Gln Tyr Leu Glu Ile Asp Glu Val Thr Thr Asp Ser Phe 
625                 630                 635                 640 


Arg Val Thr Trp His Pro Leu Ser Ala Asp Glu Gly Leu His Lys Leu 
                645                 650                 655     


Met Trp Ile Pro Val Tyr Gly Gly Lys Thr Glu Glu Val Val Leu Lys 
            660                 665                 670         


Glu Glu Gln Asp Ser His Val Ile Glu Gly Leu Glu Pro Gly Thr Glu 
        675                 680                 685             


Tyr Glu Val Ser Leu Leu Ala Val Leu Asp Asp Gly Ser Glu Ser Glu 
    690                 695                 700                 


Val Val Thr Ala Val Gly Thr Thr Leu Asp Ser Phe Trp Thr Glu Pro 
705                 710                 715                 720 


Ala Thr Thr Ile Val Pro Thr Thr Ser Val Thr Ser Val Phe Gln Thr 
                725                 730                 735     


Gly Ile Arg Asn Leu Val Val Gly Asp Glu Thr Thr Ser Ser Leu Arg 
            740                 745                 750         


Val Lys Trp Asp Ile Ser Asp Ser Asp Val Gln Gln Phe Arg Val Thr 
        755                 760                 765             


Tyr Met Thr Ala Gln Gly Asp Pro Glu Glu Glu Val Ile Gly Thr Val 
    770                 775                 780                 


Met Val Pro Gly Ser Gln Asn Asn Leu Leu Leu Lys Pro Leu Leu Pro 
785                 790                 795                 800 


Asp Thr Glu Tyr Lys Val Thr Val Thr Pro Ile Tyr Thr Asp Gly Glu 
                805                 810                 815     


Gly Val Ser Val Ser Ala Pro Gly Lys Thr Leu Pro Ser Ser Gly Pro 
            820                 825                 830         


Gln Asn Leu Arg Val Ser Glu Glu Trp Tyr Asn Arg Leu Arg Ile Thr 
        835                 840                 845             


Trp Asp Pro Pro Ser Ser Pro Val Lys Gly Tyr Arg Ile Val Tyr Lys 
    850                 855                 860                 


Pro Val Ser Val Pro Gly Pro Thr Leu Glu Thr Phe Val Gly Ala Asp 
865                 870                 875                 880 


Ile Asn Thr Ile Leu Ile Thr Asn Leu Leu Ser Gly Met Asp Tyr Asn 
                885                 890                 895     


Val Lys Ile Phe Ala Ser Gln Ala Ser Gly Phe Ser Asp Ala Leu Thr 
            900                 905                 910         


Gly Met Val Lys Thr Leu Phe Leu Gly Val Thr Asn Leu Gln Ala Lys 
        915                 920                 925             


His Val Glu Met Thr Ser Leu Cys Ala His Trp Gln Val His Arg His 
    930                 935                 940                 


Ala Thr Ala Tyr Arg Val Val Ile Glu Ser Leu Gln Asp Arg Gln Lys 
945                 950                 955                 960 


Gln Glu Ser Thr Val Gly Gly Gly Thr Thr Arg His Cys Phe Tyr Gly 
                965                 970                 975     


Leu Gln Pro Asp Ser Glu Tyr Lys Ile Ser Val Tyr Thr Lys Leu Gln 
            980                 985                 990         


Glu Ile Glu Gly Pro Ser Val Ser  Ile Met Glu Lys Thr  Gln Ser Leu 
        995                 1000                 1005             


Pro Thr  Arg Pro Pro Thr Phe  Pro Pro Thr Ile Pro  Pro Ala Lys 
    1010                 1015                 1020             


Glu Val  Cys Lys Ala Ala Lys  Ala Asp Leu Val Phe  Met Val Asp 
    1025                 1030                 1035             


Gly Ser  Trp Ser Ile Gly Asp  Glu Asn Phe Asn Lys  Ile Ile Ser 
    1040                 1045                 1050             


Phe Leu  Tyr Ser Thr Val Gly  Ala Leu Asn Lys Ile  Gly Thr Asp 
    1055                 1060                 1065             


Gly Thr  Gln Val Ala Met Val  Gln Phe Thr Asp Asp  Pro Arg Thr 
    1070                 1075                 1080             


Glu Phe  Lys Leu Asn Ala Tyr  Lys Thr Lys Glu Thr  Leu Leu Asp 
    1085                 1090                 1095             


Ala Ile  Lys His Ile Ser Tyr  Lys Gly Gly Asn Thr  Lys Thr Gly 
    1100                 1105                 1110             


Lys Ala  Ile Lys Tyr Val Arg  Asp Thr Leu Phe Thr  Ala Glu Ser 
    1115                 1120                 1125             


Gly Thr  Arg Arg Gly Ile Pro  Lys Val Ile Val Val  Ile Thr Asp 
    1130                 1135                 1140             


Gly Arg  Ser Gln Asp Asp Val  Asn Lys Ile Ser Arg  Glu Met Gln 
    1145                 1150                 1155             


Leu Asp  Gly Tyr Ser Ile Phe  Ala Ile Gly Val Ala  Asp Ala Asp 
    1160                 1165                 1170             


Tyr Ser  Glu Leu Val Ser Ile  Gly Ser Lys Pro Ser  Ala Arg His 
    1175                 1180                 1185             


Val Phe  Phe Val Asp Asp Phe  Asp Ala Phe Lys Lys  Ile Glu Asp 
    1190                 1195                 1200             


Glu Leu  Ile Thr Phe Val Cys  Glu Thr Ala Ser Ala  Thr Cys Pro 
    1205                 1210                 1215             


Val Val  His Lys Asp Gly Ile  Asp Leu Ala Gly Phe  Lys Met Met 
    1220                 1225                 1230             


Glu Met  Phe Gly Leu Val Glu  Lys Asp Phe Ser Ser  Val Glu Gly 
    1235                 1240                 1245             


Val Ser  Met Glu Pro Gly Thr  Phe Asn Val Phe Pro  Cys Tyr Gln 
    1250                 1255                 1260             


Leu His  Lys Asp Ala Leu Val  Ser Gln Pro Thr Arg  Tyr Leu His 
    1265                 1270                 1275             


Pro Glu  Gly Leu Pro Ser Asp  Tyr Thr Ile Ser Phe  Leu Phe Arg 
    1280                 1285                 1290             


Ile Leu  Pro Asp Thr Pro Gln  Glu Pro Phe Ala Leu  Trp Glu Ile 
    1295                 1300                 1305             


Leu Asn  Lys Asn Ser Asp Pro  Leu Val Gly Val Ile  Leu Asp Asn 
    1310                 1315                 1320             


Gly Gly  Lys Thr Leu Thr Tyr  Phe Asn Tyr Asp Gln  Ser Gly Asp 
    1325                 1330                 1335             


Phe Gln  Thr Val Thr Phe Glu  Gly Pro Glu Ile Arg  Lys Ile Phe 
    1340                 1345                 1350             


Tyr Gly  Ser Phe His Lys Leu  His Ile Val Val Ser  Glu Thr Leu 
    1355                 1360                 1365             


Val Lys  Val Val Ile Asp Cys  Lys Gln Val Gly Glu  Lys Ala Met 
    1370                 1375                 1380             


Asn Ala  Ser Ala Asn Ile Thr  Ser Asp Gly Val Glu  Val Leu Gly 
    1385                 1390                 1395             


Lys Met  Val Arg Ser Arg Gly  Pro Gly Gly Asn Ser  Ala Pro Phe 
    1400                 1405                 1410             


Gln Leu  Gln Met Phe Asp Ile  Val Cys Ser Thr Ser  Trp Ala Asn 
    1415                 1420                 1425             


Thr Asp  Lys Cys Cys Glu Leu  Pro Gly Leu Arg Asp  Asp Glu Ser 
    1430                 1435                 1440             


Cys Pro  Asp Leu Pro His Ser  Cys Ser Cys Ser Glu  Thr Asn Glu 
    1445                 1450                 1455             


Val Ala  Leu Gly Pro Ala Gly  Pro Pro Gly Gly Pro  Gly Leu Arg 
    1460                 1465                 1470             


Gly Pro  Lys Gly Gln Gln Gly  Glu Pro Gly Pro Lys  Gly Pro Asp 
    1475                 1480                 1485             


Gly Pro  Arg Gly Glu Ile Gly  Leu Pro Gly Pro Gln  Gly Pro Pro 
    1490                 1495                 1500             


Gly Pro  Gln Gly Pro Ser Gly  Leu Ser Ile Gln Gly  Met Pro Gly 
    1505                 1510                 1515             


Met Pro  Gly Glu Lys Gly Glu  Lys Gly Asp Thr Gly  Leu Pro Gly 
    1520                 1525                 1530             


Pro Gln  Gly Ile Pro Gly Gly  Val Gly Ser Pro Gly  Arg Asp Gly 
    1535                 1540                 1545             


Ser Pro  Gly Gln Arg Gly Leu  Pro Gly Lys Asp Gly  Ser Ser Gly 
    1550                 1555                 1560             


Pro Pro  Gly Pro Pro Gly Pro  Ile Gly Ile Pro Gly  Thr Pro Gly 
    1565                 1570                 1575             


Val Pro  Gly Ile Thr Gly Ser  Met Gly Pro Gln Gly  Ala Leu Gly 
    1580                 1585                 1590             


Pro Pro  Gly Val Pro Gly Ala  Lys Gly Glu Arg Gly  Glu Arg Gly 
    1595                 1600                 1605             


Asp Leu  Gln Ser Gln Ala Met  Val Arg Ser Val Ala  Arg Gln Val 
    1610                 1615                 1620             


Cys Glu  Gln Leu Ile Gln Ser  His Met Ala Arg Tyr  Thr Ala Ile 
    1625                 1630                 1635             


Leu Asn  Gln Ile Pro Ser His  Ser Ser Ser Ile Arg  Thr Val Gln 
    1640                 1645                 1650             


Gly Pro  Pro Gly Glu Pro Gly  Arg Pro Gly Ser Pro  Gly Ala Pro 
    1655                 1660                 1665             


Gly Glu  Gln Gly Pro Pro Gly  Thr Pro Gly Phe Pro  Gly Asn Ala 
    1670                 1675                 1680             


Gly Val  Pro Gly Thr Pro Gly  Glu Arg Gly Leu Thr  Gly Ile Lys 
    1685                 1690                 1695             


Gly Glu  Lys Gly Asn Pro Gly  Val Gly Thr Gln Gly  Pro Arg Gly 
    1700                 1705                 1710             


Pro Pro  Gly Pro Ala Gly Pro  Ser Gly Glu Ser Arg  Pro Gly Ser 
    1715                 1720                 1725             


Pro Gly  Pro Pro Gly Ser Pro  Gly Pro Arg Gly Pro  Pro Gly His 
    1730                 1735                 1740             


Leu Gly  Val Pro Gly Pro Gln  Gly Pro Ser Gly Gln  Pro Gly Tyr 
    1745                 1750                 1755             


Cys Asp  Pro Ser Ser Cys Ser  Ala Tyr Gly Val Arg  Ala Pro His 
    1760                 1765                 1770             


Pro Asp  Gln Pro Glu Phe Thr  Pro Val Gln Asp Glu  Leu Glu Ala 
    1775                 1780                 1785             


Met Glu  Leu Trp Gly Pro Gly  Val 
    1790                 1795     


<210>  4774
<211>  971
<212>  PRT
<213>  Homo sapiens

<400>  4774

Met Ala Thr Val Arg Ala Ser Leu Arg Gly Ala Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ala Val Ala Gly Val Ala Glu Val Ala Gly Gly Leu Ala Pro Gly Ser 
            20                  25                  30          


Ala Gly Ala Leu Cys Cys Asn His Ser Lys Asp Asn Gln Met Cys Arg 
        35                  40                  45              


Asp Val Cys Glu Gln Ile Phe Ser Ser Lys Ser Glu Ser Arg Leu Lys 
    50                  55                  60                  


His Leu Leu Gln Arg Ala Pro Asp Tyr Cys Pro Glu Thr Met Val Glu 
65                  70                  75                  80  


Ile Trp Asn Cys Met Asn Ser Ser Leu Pro Gly Val Phe Lys Lys Ser 
                85                  90                  95      


Asp Gly Trp Val Gly Leu Gly Cys Cys Glu Leu Ala Ile Ala Leu Glu 
            100                 105                 110         


Cys Arg Gln Ala Cys Lys Gln Ala Ser Ser Lys Asn Asp Ile Ser Lys 
        115                 120                 125             


Val Cys Arg Lys Glu Tyr Glu Asn Ala Leu Phe Ser Cys Ile Ser Arg 
    130                 135                 140                 


Asn Glu Met Gly Ser Val Cys Cys Ser Tyr Ala Gly His His Thr Asn 
145                 150                 155                 160 


Cys Arg Glu Tyr Cys Gln Ala Ile Phe Arg Thr Asp Ser Ser Pro Gly 
                165                 170                 175     


Pro Ser Gln Ile Lys Ala Val Glu Asn Tyr Cys Ala Ser Ile Ser Pro 
            180                 185                 190         


Gln Leu Ile His Cys Val Asn Asn Tyr Thr Gln Ser Tyr Pro Met Arg 
        195                 200                 205             


Asn Pro Thr Asp Ser Leu Tyr Cys Cys Asp Arg Ala Glu Asp His Ala 
    210                 215                 220                 


Cys Gln Asn Ala Cys Lys Arg Ile Leu Met Ser Lys Lys Thr Glu Met 
225                 230                 235                 240 


Glu Ile Val Asp Gly Leu Ile Glu Gly Cys Lys Thr Gln Pro Leu Pro 
                245                 250                 255     


Gln Asp Pro Leu Trp Gln Cys Phe Leu Glu Ser Ser Gln Ser Val His 
            260                 265                 270         


Pro Gly Val Thr Val His Pro Pro Pro Ser Thr Gly Leu Asp Gly Ala 
        275                 280                 285             


Lys Leu His Cys Cys Ser Lys Ala Asn Thr Ser Thr Cys Arg Glu Leu 
    290                 295                 300                 


Cys Thr Lys Leu Tyr Ser Met Ser Trp Gly Asn Thr Gln Ser Trp Gln 
305                 310                 315                 320 


Glu Phe Asp Arg Phe Cys Glu Tyr Asn Pro Val Glu Val Ser Met Leu 
                325                 330                 335     


Thr Cys Leu Ala Asp Val Arg Glu Pro Cys Gln Leu Gly Cys Arg Asn 
            340                 345                 350         


Leu Thr Tyr Cys Thr Asn Phe Asn Asn Arg Pro Thr Glu Leu Phe Arg 
        355                 360                 365             


Ser Cys Asn Ala Gln Ser Asp Gln Gly Ala Met Asn Asp Met Lys Leu 
    370                 375                 380                 


Trp Glu Lys Gly Ser Ile Lys Met Pro Phe Ile Asn Ile Pro Val Leu 
385                 390                 395                 400 


Asp Ile Lys Lys Cys Gln Pro Glu Met Trp Lys Ala Ile Ala Cys Ser 
                405                 410                 415     


Leu Gln Ile Lys Pro Cys His Ser Lys Ser Arg Gly Ser Ile Ile Cys 
            420                 425                 430         


Lys Ser Asp Cys Val Glu Ile Leu Lys Lys Cys Gly Asp Gln Asn Lys 
        435                 440                 445             


Phe Pro Glu Asp His Thr Ala Glu Ser Ile Cys Glu Leu Leu Ser Pro 
    450                 455                 460                 


Thr Asp Asp Leu Lys Asn Cys Ile Pro Leu Asp Thr Tyr Leu Arg Pro 
465                 470                 475                 480 


Ser Thr Leu Gly Asn Ile Val Glu Glu Val Thr His Pro Cys Asn Pro 
                485                 490                 495     


Asn Pro Cys Pro Ala Asn Glu Leu Cys Glu Val Asn Arg Lys Gly Cys 
            500                 505                 510         


Pro Ser Gly Asp Pro Cys Leu Pro Tyr Phe Cys Val Gln Gly Cys Lys 
        515                 520                 525             


Leu Gly Glu Ala Ser Asp Phe Ile Val Arg Gln Gly Thr Leu Ile Gln 
    530                 535                 540                 


Val Pro Ser Ser Ala Gly Glu Val Gly Cys Tyr Lys Ile Cys Ser Cys 
545                 550                 555                 560 


Gly Gln Ser Gly Leu Leu Glu Asn Cys Met Glu Met His Cys Ile Asp 
                565                 570                 575     


Leu Gln Lys Ser Cys Ile Val Gly Gly Lys Arg Lys Ser His Gly Thr 
            580                 585                 590         


Ser Phe Ser Ile Asp Cys Asn Val Cys Ser Cys Phe Ala Gly Asn Leu 
        595                 600                 605             


Val Cys Ser Thr Arg Leu Cys Leu Ser Glu His Ser Ser Glu Asp Asp 
    610                 615                 620                 


Arg Arg Thr Phe Thr Gly Leu Pro Cys Asn Cys Ala Asp Gln Phe Val 
625                 630                 635                 640 


Pro Val Cys Gly Gln Asn Gly Arg Thr Tyr Pro Ser Ala Cys Ile Ala 
                645                 650                 655     


Arg Cys Val Gly Leu Gln Asp His Gln Phe Glu Phe Gly Ser Cys Met 
            660                 665                 670         


Ser Lys Asp Pro Cys Asn Pro Asn Pro Cys Gln Lys Asn Gln Arg Cys 
        675                 680                 685             


Ile Pro Lys Pro Gln Val Cys Leu Thr Thr Phe Asp Lys Phe Gly Cys 
    690                 695                 700                 


Ser Gln Tyr Glu Cys Val Pro Arg Gln Leu Ala Cys Asp Gln Val Gln 
705                 710                 715                 720 


Asp Pro Val Cys Asp Thr Asp His Met Glu His Asn Asn Leu Cys Thr 
                725                 730                 735     


Leu Tyr Gln Arg Gly Lys Ser Leu Ser Tyr Lys Gly Pro Cys Gln Pro 
            740                 745                 750         


Phe Cys Arg Ala Thr Glu Pro Val Cys Gly His Asn Gly Glu Thr Tyr 
        755                 760                 765             


Ser Ser Val Cys Ala Ala Tyr Ser Asp Arg Val Ala Val Asp Tyr Tyr 
    770                 775                 780                 


Gly Asp Cys Gln Ala Val Gly Val Leu Ser Glu His Ser Ser Val Ala 
785                 790                 795                 800 


Glu Cys Ala Ser Val Lys Cys Pro Ser Leu Leu Ala Ala Gly Cys Lys 
                805                 810                 815     


Pro Ile Ile Pro Pro Gly Ala Cys Cys Pro Leu Cys Ala Gly Met Leu 
            820                 825                 830         


Arg Val Leu Phe Asp Lys Glu Lys Leu Asp Thr Ile Ala Lys Val Thr 
        835                 840                 845             


Asn Lys Lys Pro Ile Thr Val Leu Glu Ile Leu Gln Lys Ile Arg Met 
    850                 855                 860                 


His Val Ser Val Pro Gln Cys Asp Val Phe Gly Tyr Phe Ser Ile Glu 
865                 870                 875                 880 


Ser Glu Ile Val Ile Leu Ile Ile Pro Val Asp His Tyr Pro Lys Ala 
                885                 890                 895     


Leu Gln Ile Glu Ala Cys Asn Lys Glu Ala Glu Lys Ile Glu Ser Leu 
            900                 905                 910         


Ile Asn Ser Asp Ser Pro Thr Leu Ala Ser His Val Pro Leu Ser Ala 
        915                 920                 925             


Leu Ile Ile Ser Gln Val Gln Val Ser Ser Ser Val Pro Ser Ala Gly 
    930                 935                 940                 


Val Arg Ala Arg Pro Ser Cys His Ser Leu Leu Leu Pro Leu Ser Leu 
945                 950                 955                 960 


Gly Leu Ala Leu His Leu Leu Trp Thr Tyr Asn 
                965                 970     


<210>  4775
<211>  84
<212>  PRT
<213>  Homo sapiens

<400>  4775

Met Ala Leu Ser Val Leu Arg Leu Ala Leu Leu Leu Leu Ala Val Thr 
1               5                   10                  15      


Phe Ala Ala Ser Leu Ile Pro Gln Phe Gly Leu Phe Ser Lys Tyr Arg 
            20                  25                  30          


Thr Pro Asn Cys Ser Gln Tyr Arg Leu Pro Gly Cys Pro Arg His Phe 
        35                  40                  45              


Asn Pro Val Cys Gly Ser Asp Met Ser Thr Tyr Ala Asn Glu Cys Thr 
    50                  55                  60                  


Leu Cys Met Lys Ile Arg Glu Gly Gly His Asn Ile Lys Ile Ile Arg 
65                  70                  75                  80  


Asn Gly Pro Cys 
                


<210>  4776
<211>  1024
<212>  PRT
<213>  Homo sapiens

<400>  4776

Met Pro Ala Ala Arg Pro Pro Ala Ala Gly Leu Arg Gly Ile Ser Leu 
1               5                   10                  15      


Phe Leu Ala Leu Leu Leu Gly Ser Pro Ala Ala Ala Leu Glu Arg Asp 
            20                  25                  30          


Ala Leu Pro Glu Gly Asp Ala Ser Pro Leu Gly Pro Tyr Leu Leu Pro 
        35                  40                  45              


Ser Gly Ala Pro Glu Arg Gly Ser Pro Gly Lys Glu His Pro Glu Glu 
    50                  55                  60                  


Arg Val Val Thr Ala Pro Pro Ser Ser Ser Gln Ser Ala Glu Val Leu 
65                  70                  75                  80  


Gly Glu Leu Val Leu Asp Gly Thr Ala Pro Ser Ala His His Asp Ile 
                85                  90                  95      


Pro Ala Leu Ser Pro Leu Leu Pro Glu Glu Ala Arg Pro Lys His Ala 
            100                 105                 110         


Leu Pro Pro Lys Lys Lys Leu Pro Ser Leu Lys Gln Val Asn Ser Ala 
        115                 120                 125             


Arg Lys Gln Leu Arg Pro Lys Ala Thr Ser Ala Ala Thr Val Gln Arg 
    130                 135                 140                 


Ala Gly Ser Gln Pro Ala Ser Gln Gly Leu Asp Leu Leu Ser Ser Ser 
145                 150                 155                 160 


Thr Glu Lys Pro Gly Pro Pro Gly Asp Pro Asp Pro Ile Val Ala Ser 
                165                 170                 175     


Glu Glu Ala Ser Glu Val Pro Leu Trp Leu Asp Arg Lys Glu Ser Ala 
            180                 185                 190         


Val Pro Thr Thr Pro Ala Pro Leu Gln Ile Ser Pro Phe Thr Ser Gln 
        195                 200                 205             


Pro Tyr Val Ala His Thr Leu Pro Gln Arg Pro Glu Pro Gly Glu Pro 
    210                 215                 220                 


Gly Pro Asp Met Ala Gln Glu Ala Pro Gln Glu Asp Thr Ser Pro Met 
225                 230                 235                 240 


Ala Leu Met Asp Lys Gly Glu Asn Glu Leu Thr Gly Ser Ala Ser Glu 
                245                 250                 255     


Glu Ser Gln Glu Thr Thr Thr Ser Thr Ile Ile Thr Thr Thr Val Ile 
            260                 265                 270         


Thr Thr Glu Gln Ala Pro Ala Leu Cys Ser Val Ser Phe Ser Asn Pro 
        275                 280                 285             


Glu Gly Tyr Ile Asp Ser Ser Asp Tyr Pro Leu Leu Pro Leu Asn Asn 
    290                 295                 300                 


Phe Leu Glu Cys Thr Tyr Asn Val Thr Val Tyr Thr Gly Tyr Gly Val 
305                 310                 315                 320 


Glu Leu Gln Val Lys Ser Val Asn Leu Ser Asp Gly Glu Leu Leu Ser 
                325                 330                 335     


Ile Arg Gly Val Asp Gly Pro Thr Leu Thr Val Leu Ala Asn Gln Thr 
            340                 345                 350         


Leu Leu Val Glu Gly Gln Val Ile Arg Ser Pro Thr Asn Thr Ile Ser 
        355                 360                 365             


Val Tyr Phe Arg Thr Phe Gln Asp Asp Gly Leu Gly Thr Phe Gln Leu 
    370                 375                 380                 


His Tyr Gln Ala Phe Met Leu Ser Cys Asn Phe Pro Arg Arg Pro Asp 
385                 390                 395                 400 


Ser Gly Asp Val Thr Val Met Asp Leu His Ser Gly Gly Val Ala His 
                405                 410                 415     


Phe His Cys His Leu Gly Tyr Glu Leu Gln Gly Ala Lys Met Leu Thr 
            420                 425                 430         


Cys Ile Asn Ala Ser Lys Pro His Trp Ser Ser Gln Glu Pro Ile Cys 
        435                 440                 445             


Ser Ala Pro Cys Gly Gly Ala Val His Asn Ala Thr Ile Gly Arg Val 
    450                 455                 460                 


Leu Ser Pro Ser Tyr Pro Glu Asn Thr Asn Gly Ser Gln Phe Cys Ile 
465                 470                 475                 480 


Trp Thr Ile Glu Ala Pro Glu Gly Gln Lys Leu His Leu His Phe Glu 
                485                 490                 495     


Arg Leu Leu Leu His Asp Lys Asp Arg Met Thr Val His Ser Gly Gln 
            500                 505                 510         


Thr Asn Lys Ser Ala Leu Leu Tyr Asp Ser Leu Gln Thr Glu Ser Val 
        515                 520                 525             


Pro Phe Glu Gly Leu Leu Ser Glu Gly Asn Thr Ile Arg Ile Glu Phe 
    530                 535                 540                 


Thr Ser Asp Gln Ala Arg Ala Ala Ser Thr Phe Asn Ile Arg Phe Glu 
545                 550                 555                 560 


Ala Phe Glu Lys Gly His Cys Tyr Glu Pro Tyr Ile Gln Asn Gly Asn 
                565                 570                 575     


Phe Thr Thr Ser Asp Pro Thr Tyr Asn Ile Gly Thr Ile Val Glu Phe 
            580                 585                 590         


Thr Cys Asp Pro Gly His Ser Leu Glu Gln Gly Pro Ala Ile Ile Glu 
        595                 600                 605             


Cys Ile Asn Val Arg Asp Pro Tyr Trp Asn Asp Thr Glu Pro Leu Cys 
    610                 615                 620                 


Arg Ala Met Cys Gly Gly Glu Leu Ser Ala Val Ala Gly Val Val Leu 
625                 630                 635                 640 


Ser Pro Asn Trp Pro Glu Pro Tyr Val Glu Gly Glu Asp Cys Ile Trp 
                645                 650                 655     


Lys Ile His Val Gly Glu Glu Lys Arg Ile Phe Leu Asp Ile Gln Phe 
            660                 665                 670         


Leu Asn Leu Ser Asn Ser Asp Ile Leu Thr Ile Tyr Asp Gly Asp Glu 
        675                 680                 685             


Val Met Pro His Ile Leu Gly Gln Tyr Leu Gly Asn Ser Gly Pro Gln 
    690                 695                 700                 


Lys Leu Tyr Ser Ser Thr Pro Asp Leu Thr Ile Gln Phe His Ser Asp 
705                 710                 715                 720 


Pro Ala Gly Leu Ile Phe Gly Lys Gly Gln Gly Phe Ile Met Asn Tyr 
                725                 730                 735     


Ile Glu Val Ser Arg Asn Asp Ser Cys Ser Asp Leu Pro Glu Ile Gln 
            740                 745                 750         


Asn Gly Trp Lys Thr Thr Ser His Thr Glu Leu Val Arg Gly Ala Arg 
        755                 760                 765             


Ile Thr Tyr Gln Cys Asp Pro Gly Tyr Asp Ile Val Gly Ser Asp Thr 
    770                 775                 780                 


Leu Thr Cys Gln Trp Asp Leu Ser Trp Ser Ser Asp Pro Pro Phe Cys 
785                 790                 795                 800 


Glu Lys Ile Met Tyr Cys Thr Asp Pro Gly Glu Val Asp His Ser Thr 
                805                 810                 815     


Arg Leu Ile Ser Asp Pro Val Leu Leu Val Gly Thr Thr Ile Gln Tyr 
            820                 825                 830         


Thr Cys Asn Pro Gly Phe Val Leu Glu Gly Ser Ser Leu Leu Thr Cys 
        835                 840                 845             


Tyr Ser Arg Glu Thr Gly Thr Pro Ile Trp Thr Ser Arg Leu Pro His 
    850                 855                 860                 


Cys Val Ser Glu Glu Ser Leu Ala Cys Asp Asn Pro Gly Leu Pro Glu 
865                 870                 875                 880 


Asn Gly Tyr Gln Ile Leu Tyr Lys Arg Leu Tyr Leu Pro Gly Glu Ser 
                885                 890                 895     


Leu Thr Phe Met Cys Tyr Glu Gly Phe Glu Leu Met Gly Glu Val Thr 
            900                 905                 910         


Ile Arg Cys Ile Leu Gly Gln Pro Ser His Trp Asn Gly Pro Leu Pro 
        915                 920                 925             


Val Cys Lys Val Asn Gln Asp Ser Phe Glu His Ala Leu Glu Val Ala 
    930                 935                 940                 


Glu Ala Ala Ala Glu Thr Ser Leu Glu Gly Gly Asn Met Ala Leu Ala 
945                 950                 955                 960 


Ile Phe Ile Pro Val Leu Ile Ile Ser Leu Leu Leu Gly Gly Ala Tyr 
                965                 970                 975     


Ile Tyr Ile Thr Arg Cys Arg Tyr Tyr Ser Asn Leu Arg Leu Pro Leu 
            980                 985                 990         


Met Tyr Ser His Pro Tyr Ser Gln  Ile Thr Val Glu Thr  Glu Phe Asp 
        995                 1000                 1005             


Asn Pro  Ile Tyr Glu Thr Gly  Glu Thr Arg Glu Tyr  Glu Val Ser 
    1010                 1015                 1020             


Ile 
    


<210>  4777
<211>  1119
<212>  PRT
<213>  Homo sapiens

<400>  4777

Met Ala Gly Ala Pro Arg Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly 
1               5                   10                  15      


Glu Pro Gly Gly Ala Glu Arg Ala Ala Gly Thr Ser Arg Arg Arg Gly 
            20                  25                  30          


Leu Arg Ala Cys Asp Glu Glu Phe Ala Cys Pro Glu Leu Glu Ala Leu 
        35                  40                  45              


Phe Arg Gly Tyr Thr Leu Arg Leu Glu Gln Ala Ala Thr Leu Lys Ala 
    50                  55                  60                  


Leu Ala Val Leu Ser Leu Leu Ala Gly Ala Leu Ala Leu Ala Glu Leu 
65                  70                  75                  80  


Leu Gly Ala Pro Gly Pro Ala Pro Gly Leu Ala Lys Gly Ser His Pro 
                85                  90                  95      


Val His Cys Val Leu Phe Leu Ala Leu Leu Val Val Thr Asn Val Arg 
            100                 105                 110         


Ser Leu Gln Val Pro Gln Leu Gln Gln Val Gly Gln Leu Ala Leu Leu 
        115                 120                 125             


Phe Ser Leu Thr Phe Ala Leu Leu Cys Cys Pro Phe Ala Leu Gly Gly 
    130                 135                 140                 


Pro Ala Arg Gly Ser Ala Gly Ala Ala Gly Gly Pro Ala Thr Ala Glu 
145                 150                 155                 160 


Gln Gly Val Trp Gln Leu Leu Leu Val Thr Phe Val Ser Tyr Ala Leu 
                165                 170                 175     


Leu Pro Val Arg Ser Leu Leu Ala Ile Gly Phe Gly Leu Val Val Ala 
            180                 185                 190         


Ala Ser His Leu Leu Val Thr Ala Thr Leu Val Pro Ala Lys Arg Pro 
        195                 200                 205             


Arg Leu Trp Arg Thr Leu Gly Ala Asn Ala Leu Leu Phe Val Gly Val 
    210                 215                 220                 


Asn Met Tyr Gly Val Phe Val Arg Ile Leu Thr Glu Arg Ser Gln Arg 
225                 230                 235                 240 


Lys Ala Phe Leu Gln Ala Arg Ser Cys Ile Glu Asp Arg Leu Arg Leu 
                245                 250                 255     


Glu Asp Glu Asn Glu Lys Gln Glu Arg Leu Leu Met Ser Leu Leu Pro 
            260                 265                 270         


Arg Asn Val Ala Met Glu Met Lys Glu Asp Phe Leu Lys Pro Pro Glu 
        275                 280                 285             


Arg Ile Phe His Lys Ile Tyr Ile Gln Arg His Asp Asn Val Ser Ile 
    290                 295                 300                 


Leu Phe Ala Asp Ile Val Gly Phe Thr Gly Leu Ala Ser Gln Cys Thr 
305                 310                 315                 320 


Ala Gln Glu Leu Val Lys Leu Leu Asn Glu Leu Phe Gly Lys Phe Asp 
                325                 330                 335     


Glu Leu Ala Thr Glu Asn His Cys Arg Arg Ile Lys Ile Leu Gly Asp 
            340                 345                 350         


Cys Tyr Tyr Cys Val Ser Gly Leu Thr Gln Pro Lys Thr Asp His Ala 
        355                 360                 365             


His Cys Cys Val Glu Met Gly Leu Asp Met Ile Asp Thr Ile Thr Ser 
    370                 375                 380                 


Val Ala Glu Ala Thr Glu Val Asp Leu Asn Met Arg Val Gly Leu His 
385                 390                 395                 400 


Thr Gly Arg Val Leu Cys Gly Val Leu Gly Leu Arg Lys Trp Gln Tyr 
                405                 410                 415     


Asp Val Trp Ser Asn Asp Val Thr Leu Ala Asn Val Met Glu Ala Ala 
            420                 425                 430         


Gly Leu Pro Gly Lys Val His Ile Thr Lys Thr Thr Leu Ala Cys Leu 
        435                 440                 445             


Asn Gly Asp Tyr Glu Val Glu Pro Gly Tyr Gly His Glu Arg Asn Ser 
    450                 455                 460                 


Phe Leu Lys Thr His Asn Ile Glu Thr Phe Phe Ile Val Pro Ser His 
465                 470                 475                 480 


Arg Arg Lys Ile Phe Pro Gly Leu Ile Leu Ser Asp Ile Lys Pro Ala 
                485                 490                 495     


Lys Arg Met Lys Phe Lys Thr Val Cys Tyr Leu Leu Val Gln Leu Met 
            500                 505                 510         


His Cys Arg Lys Met Phe Lys Ala Glu Ile Pro Phe Ser Asn Val Met 
        515                 520                 525             


Thr Cys Glu Asp Asp Asp Lys Arg Arg Ala Leu Arg Thr Ala Ser Glu 
    530                 535                 540                 


Lys Leu Arg Asn Arg Ser Ser Phe Ser Thr Asn Val Val Tyr Thr Thr 
545                 550                 555                 560 


Pro Gly Thr Arg Val Asn Arg Tyr Ile Ser Arg Leu Leu Glu Ala Arg 
                565                 570                 575     


Gln Thr Glu Leu Glu Met Ala Asp Leu Asn Phe Phe Thr Leu Lys Tyr 
            580                 585                 590         


Lys His Val Glu Arg Glu Gln Lys Tyr His Gln Leu Gln Asp Glu Tyr 
        595                 600                 605             


Phe Thr Ser Ala Val Val Leu Thr Leu Ile Leu Ala Ala Leu Phe Gly 
    610                 615                 620                 


Leu Val Tyr Leu Leu Ile Phe Pro Gln Ser Val Val Val Leu Leu Leu 
625                 630                 635                 640 


Leu Val Phe Cys Ile Cys Phe Leu Val Ala Cys Val Leu Tyr Leu His 
                645                 650                 655     


Ile Thr Arg Val Gln Cys Phe Pro Gly Cys Leu Thr Ile Gln Ile Arg 
            660                 665                 670         


Thr Val Leu Cys Ile Phe Ile Val Val Leu Ile Tyr Ser Val Ala Gln 
        675                 680                 685             


Gly Cys Val Val Gly Cys Leu Pro Trp Ala Trp Ser Ser Lys Pro Asn 
    690                 695                 700                 


Ser Ser Leu Val Val Leu Ser Ser Gly Gly Gln Arg Thr Ala Leu Pro 
705                 710                 715                 720 


Thr Leu Pro Cys Glu Ser Thr His His Ala Leu Leu Cys Cys Leu Val 
                725                 730                 735     


Gly Thr Leu Pro Leu Ala Ile Phe Phe Arg Val Ser Ser Leu Pro Lys 
            740                 745                 750         


Met Ile Leu Leu Ser Gly Leu Thr Thr Ser Tyr Ile Leu Val Leu Glu 
        755                 760                 765             


Leu Ser Gly Tyr Thr Arg Thr Gly Gly Gly Ala Val Ser Gly Arg Ser 
    770                 775                 780                 


Tyr Glu Pro Ile Val Ala Ile Leu Leu Phe Ser Cys Ala Leu Ala Leu 
785                 790                 795                 800 


His Ala Arg Gln Val Asp Ile Arg Leu Arg Leu Asp Tyr Leu Trp Ala 
                805                 810                 815     


Ala Gln Ala Glu Glu Glu Arg Glu Asp Met Glu Lys Val Lys Leu Asp 
            820                 825                 830         


Asn Arg Arg Ile Leu Phe Asn Leu Leu Pro Ala His Val Ala Gln His 
        835                 840                 845             


Phe Leu Met Ser Asn Pro Arg Asn Met Asp Leu Tyr Tyr Gln Ser Tyr 
    850                 855                 860                 


Ser Gln Val Gly Val Met Phe Ala Ser Ile Pro Asn Phe Asn Asp Phe 
865                 870                 875                 880 


Tyr Ile Glu Leu Asp Gly Asn Asn Met Gly Val Glu Cys Leu Arg Leu 
                885                 890                 895     


Leu Asn Glu Ile Ile Ala Asp Phe Asp Glu Leu Met Glu Lys Asp Phe 
            900                 905                 910         


Tyr Lys Asp Ile Glu Lys Ile Lys Thr Ile Gly Ser Thr Tyr Met Ala 
        915                 920                 925             


Ala Val Gly Leu Ala Pro Thr Ser Gly Thr Lys Ala Lys Lys Ser Ile 
    930                 935                 940                 


Ser Ser His Leu Ser Thr Leu Ala Asp Phe Ala Ile Glu Met Phe Asp 
945                 950                 955                 960 


Val Leu Asp Glu Ile Asn Tyr Gln Ser Tyr Asn Asp Phe Val Leu Arg 
                965                 970                 975     


Val Gly Ile Asn Val Gly Pro Val Val Ala Gly Val Ile Gly Ala Arg 
            980                 985                 990         


Arg Pro Gln Tyr Asp Ile Trp Gly  Asn Thr Val Asn Val  Ala Ser Arg 
        995                 1000                 1005             


Met Asp  Ser Thr Gly Val Gln  Gly Arg Ile Gln Val  Thr Glu Glu 
    1010                 1015                 1020             


Val His  Arg Leu Leu Arg Arg  Cys Pro Tyr His Phe  Val Cys Arg 
    1025                 1030                 1035             


Gly Lys  Val Ser Val Lys Gly  Lys Gly Glu Met Leu  Thr Tyr Phe 
    1040                 1045                 1050             


Leu Glu  Gly Arg Thr Asp Gly  Asn Gly Ser Gln Ile  Arg Ser Leu 
    1055                 1060                 1065             


Gly Leu  Asp Arg Lys Met Cys  Pro Phe Gly Arg Ala  Gly Leu Gln 
    1070                 1075                 1080             


Gly Arg  Arg Pro Pro Val Cys  Pro Met Pro Gly Val  Ser Val Arg 
    1085                 1090                 1095             


Ala Gly  Leu Pro Pro His Ser  Pro Gly Gln Tyr Leu  Pro Ser Ala 
    1100                 1105                 1110             


Ala Ala  Gly Lys Glu Ala 
    1115                 


<210>  4778
<211>  614
<212>  PRT
<213>  Homo sapiens

<400>  4778

Met Gly Gly Val His Val Ala Tyr Arg Gly Gly Ala Gly Val Ala Gly 
1               5                   10                  15      


Ala Val Trp Thr Val Met Ala Ala Thr Val Ala Thr Ala Ala Ala Val 
            20                  25                  30          


Ala Pro Ala Pro Ala Pro Gly Thr Asp Ser Ala Ser Ser Val His Trp 
        35                  40                  45              


Phe Arg Lys Gly Leu Arg Leu His Asp Asn Pro Ala Leu Leu Ala Ala 
    50                  55                  60                  


Val Arg Gly Ala Arg Cys Val Arg Cys Val Tyr Ile Leu Asp Pro Trp 
65                  70                  75                  80  


Phe Ala Ala Ser Ser Ser Val Gly Ile Asn Arg Trp Arg Phe Leu Leu 
                85                  90                  95      


Gln Ser Leu Glu Asp Leu Asp Thr Ser Leu Arg Lys Leu Asn Ser Arg 
            100                 105                 110         


Leu Phe Val Val Arg Gly Gln Pro Ala Asp Val Phe Pro Arg Leu Phe 
        115                 120                 125             


Lys Glu Trp Gly Val Thr Arg Leu Thr Phe Glu Tyr Asp Ser Glu Pro 
    130                 135                 140                 


Phe Gly Lys Glu Arg Asp Ala Ala Ile Met Lys Met Ala Lys Glu Ala 
145                 150                 155                 160 


Gly Val Glu Val Val Thr Glu Asn Ser His Thr Leu Tyr Asp Leu Asp 
                165                 170                 175     


Arg Ile Ile Glu Leu Asn Gly Gln Lys Pro Pro Leu Thr Tyr Lys Arg 
            180                 185                 190         


Phe Gln Ala Ile Ile Ser Arg Met Glu Leu Pro Lys Lys Pro Val Gly 
        195                 200                 205             


Leu Val Thr Ser Gln Gln Met Glu Ser Cys Arg Ala Glu Ile Gln Glu 
    210                 215                 220                 


Asn His Asp Glu Thr Tyr Gly Val Pro Ser Leu Glu Glu Leu Gly Phe 
225                 230                 235                 240 


Pro Thr Glu Gly Leu Gly Pro Ala Val Trp Gln Gly Gly Glu Thr Glu 
                245                 250                 255     


Ala Leu Ala Arg Leu Asp Lys His Leu Glu Arg Lys Ala Trp Val Ala 
            260                 265                 270         


Asn Tyr Glu Arg Pro Arg Met Asn Ala Asn Ser Leu Leu Ala Ser Pro 
        275                 280                 285             


Thr Gly Leu Ser Pro Tyr Leu Arg Phe Gly Cys Leu Ser Cys Arg Leu 
    290                 295                 300                 


Phe Tyr Tyr Arg Leu Trp Asp Leu Tyr Lys Lys Val Lys Arg Asn Ser 
305                 310                 315                 320 


Thr Pro Pro Leu Ser Leu Phe Gly Gln Leu Leu Trp Arg Glu Phe Phe 
                325                 330                 335     


Tyr Thr Ala Ala Thr Asn Asn Pro Arg Phe Asp Arg Met Glu Gly Asn 
            340                 345                 350         


Pro Ile Cys Ile Gln Ile Pro Trp Asp Arg Asn Pro Glu Ala Leu Ala 
        355                 360                 365             


Lys Trp Ala Glu Gly Lys Thr Gly Phe Pro Trp Ile Asp Ala Ile Met 
    370                 375                 380                 


Thr Gln Leu Arg Gln Glu Gly Trp Ile His His Leu Ala Arg His Ala 
385                 390                 395                 400 


Val Ala Cys Phe Leu Thr Arg Gly Asp Leu Trp Val Ser Trp Glu Ser 
                405                 410                 415     


Gly Val Arg Val Phe Asp Glu Leu Leu Leu Asp Ala Asp Phe Ser Val 
            420                 425                 430         


Asn Ala Gly Ser Trp Met Trp Leu Ser Cys Ser Ala Phe Phe Gln Gln 
        435                 440                 445             


Phe Phe His Cys Tyr Cys Pro Val Gly Phe Gly Arg Arg Thr Asp Pro 
    450                 455                 460                 


Ser Gly Asp Tyr Ile Arg Arg Tyr Leu Pro Lys Leu Lys Ala Phe Pro 
465                 470                 475                 480 


Ser Arg Tyr Ile Tyr Glu Pro Trp Asn Ala Pro Glu Ser Ile Gln Lys 
                485                 490                 495     


Ala Ala Lys Cys Ile Ile Gly Val Asp Tyr Pro Arg Pro Ile Val Asn 
            500                 505                 510         


His Ala Glu Thr Ser Arg Leu Asn Ile Glu Arg Met Lys Gln Ile Tyr 
        515                 520                 525             


Gln Gln Leu Ser Arg Tyr Arg Gly Leu Cys Leu Leu Ala Ser Val Pro 
    530                 535                 540                 


Ser Cys Val Glu Asp Leu Ser His Pro Val Ala Glu Pro Ser Ser Ser 
545                 550                 555                 560 


Gln Ala Gly Ser Met Ser Ser Ala Gly Pro Arg Pro Leu Pro Ser Gly 
                565                 570                 575     


Pro Ala Ser Pro Lys Arg Lys Leu Glu Ala Ala Glu Glu Pro Pro Gly 
            580                 585                 590         


Glu Glu Leu Ser Lys Arg Ala Arg Val Ala Glu Leu Pro Thr Pro Glu 
        595                 600                 605             


Leu Pro Ser Lys Asp Ala 
    610                 


<210>  4779
<211>  776
<212>  PRT
<213>  Homo sapiens

<400>  4779

Met Ala Ala Pro Gly Asp Pro Gln Asp Glu Leu Leu Pro Leu Ala Gly 
1               5                   10                  15      


Pro Gly Ser Gln Trp Leu Arg His Arg Gly Glu Gly Glu Asn Glu Ala 
            20                  25                  30          


Val Thr Pro Lys Gly Ala Thr Pro Ala Pro Gln Ala Gly Glu Pro Ser 
        35                  40                  45              


Pro Gly Leu Gly Ala Arg Ala Arg Glu Ala Ala Ser Arg Glu Ala Gly 
    50                  55                  60                  


Ser Gly Pro Ala Arg Gln Ser Pro Val Ala Met Glu Thr Ala Ser Thr 
65                  70                  75                  80  


Gly Val Ala Gly Val Ser Ser Ala Met Asp His Thr Phe Ser Thr Thr 
                85                  90                  95      


Ser Lys Asp Gly Glu Gly Ser Cys Tyr Thr Ser Leu Ile Ser Asp Ile 
            100                 105                 110         


Cys Tyr Pro Pro Gln Glu Asp Ser Thr Tyr Phe Thr Gly Ile Leu Gln 
        115                 120                 125             


Lys Glu Asn Gly His Val Thr Ile Ser Glu Ser Pro Glu Glu Leu Gly 
    130                 135                 140                 


Thr Pro Gly Pro Ser Leu Pro Asp Val Pro Gly Ile Glu Ser Arg Gly 
145                 150                 155                 160 


Leu Phe Ser Ser Asp Ser Gly Ile Glu Met Thr Pro Ala Glu Ser Thr 
                165                 170                 175     


Glu Val Asn Lys Ile Leu Ala Asp Pro Leu Asp Gln Met Lys Ala Glu 
            180                 185                 190         


Ala Tyr Lys Tyr Ile Asp Ile Thr Arg Pro Glu Glu Val Lys His Gln 
        195                 200                 205             


Glu Gln His His Pro Glu Leu Glu Asp Lys Asp Leu Asp Phe Lys Asn 
    210                 215                 220                 


Lys Asp Thr Asp Ile Ser Ile Lys Pro Glu Gly Val Arg Glu Pro Asp 
225                 230                 235                 240 


Lys Pro Ala Pro Val Glu Gly Lys Ile Ile Lys Asp His Leu Leu Glu 
                245                 250                 255     


Glu Ser Thr Phe Ala Pro Tyr Ile Asp Asp Leu Ser Glu Glu Gln Arg 
            260                 265                 270         


Arg Ala Pro Gln Ile Thr Thr Pro Val Lys Ile Thr Leu Thr Glu Ile 
        275                 280                 285             


Glu Pro Ser Val Glu Thr Thr Thr Gln Glu Lys Thr Pro Glu Lys Gln 
    290                 295                 300                 


Asp Ile Cys Leu Lys Pro Ser Pro Asp Thr Val Pro Thr Val Thr Val 
305                 310                 315                 320 


Ser Glu Pro Glu Asp Asp Ser Pro Gly Ser Ile Thr Pro Pro Ser Ser 
                325                 330                 335     


Gly Thr Glu Pro Ser Ala Ala Glu Ser Gln Gly Lys Gly Ser Ile Ser 
            340                 345                 350         


Glu Asp Glu Leu Ile Thr Ala Ile Lys Glu Ala Lys Gly Leu Ser Tyr 
        355                 360                 365             


Glu Thr Ala Glu Asn Pro Arg Pro Val Gly Gln Leu Ala Asp Arg Pro 
    370                 375                 380                 


Glu Val Lys Ala Arg Ser Gly Pro Pro Thr Ile Pro Ser Pro Leu Asp 
385                 390                 395                 400 


His Glu Ala Ser Ser Ala Glu Ser Gly Asp Ser Glu Ile Glu Leu Val 
                405                 410                 415     


Ser Glu Asp Pro Met Ala Ala Glu Asp Ala Leu Pro Ser Gly Tyr Val 
            420                 425                 430         


Ser Phe Gly His Val Gly Gly Pro Pro Pro Ser Pro Ala Ser Pro Ser 
        435                 440                 445             


Ile Gln Tyr Ser Ile Leu Arg Glu Glu Arg Glu Ala Glu Leu Asp Ser 
    450                 455                 460                 


Glu Leu Ile Ile Glu Ser Cys Asp Ala Ser Ser Ala Ser Glu Glu Ser 
465                 470                 475                 480 


Pro Lys Arg Glu Gln Asp Ser Pro Pro Met Lys Pro Ser Ala Leu Asp 
                485                 490                 495     


Ala Ile Arg Glu Glu Thr Gly Val Arg Ala Glu Glu Arg Ala Pro Ser 
            500                 505                 510         


Arg Arg Gly Leu Ala Glu Pro Gly Ser Phe Leu Asp Tyr Pro Ser Thr 
        515                 520                 525             


Glu Pro Gln Pro Gly Pro Glu Leu Pro Pro Gly Asp Gly Ala Leu Glu 
    530                 535                 540                 


Pro Glu Thr Pro Met Leu Pro Arg Lys Pro Glu Glu Asp Ser Ser Ser 
545                 550                 555                 560 


Asn Gln Ser Pro Ala Ala Thr Lys Gly Pro Gly Pro Leu Gly Pro Gly 
                565                 570                 575     


Ala Pro Pro Pro Leu Leu Phe Leu Asn Lys Gln Lys Ala Ile Asp Leu 
            580                 585                 590         


Leu Tyr Trp Arg Asp Ile Lys Gln Thr Gly Ile Val Phe Gly Ser Phe 
        595                 600                 605             


Leu Leu Leu Leu Phe Ser Leu Thr Gln Phe Ser Val Val Ser Val Val 
    610                 615                 620                 


Ala Tyr Leu Ala Leu Ala Ala Leu Ser Ala Thr Ile Ser Phe Arg Ile 
625                 630                 635                 640 


Tyr Lys Ser Val Leu Gln Ala Val Gln Lys Thr Asp Glu Gly His Pro 
                645                 650                 655     


Phe Lys Ala Tyr Leu Glu Leu Glu Ile Thr Leu Ser Gln Glu Gln Ile 
            660                 665                 670         


Gln Lys Tyr Thr Asp Cys Leu Gln Phe Tyr Val Asn Ser Thr Leu Lys 
        675                 680                 685             


Glu Leu Arg Arg Leu Phe Leu Val Gln Asp Leu Val Asp Ser Leu Lys 
    690                 695                 700                 


Phe Ala Val Leu Met Trp Leu Leu Thr Tyr Val Gly Ala Leu Phe Asn 
705                 710                 715                 720 


Gly Leu Thr Leu Leu Leu Met Ala Val Val Ser Met Phe Thr Leu Pro 
                725                 730                 735     


Val Val Tyr Val Lys His Gln Ala Gln Ile Asp Gln Tyr Leu Gly Leu 
            740                 745                 750         


Val Arg Thr His Ile Asn Ala Val Val Ala Lys Ile Gln Ala Lys Ile 
        755                 760                 765             


Pro Gly Ala Lys Arg His Ala Glu 
    770                 775     


<210>  4780
<211>  528
<212>  PRT
<213>  Homo sapiens

<400>  4780

Met Ser Met Lys Trp Thr Ser Ala Leu Leu Leu Ile Gln Leu Ser Cys 
1               5                   10                  15      


Tyr Phe Ser Ser Gly Ser Cys Gly Lys Val Leu Val Trp Pro Thr Glu 
            20                  25                  30          


Phe Ser His Trp Met Asn Ile Lys Thr Ile Leu Asp Glu Leu Val Gln 
        35                  40                  45              


Arg Gly His Glu Val Thr Val Leu Ala Ser Ser Ala Ser Ile Ser Phe 
    50                  55                  60                  


Asp Pro Asn Ser Pro Ser Thr Leu Lys Phe Glu Val Tyr Pro Val Ser 
65                  70                  75                  80  


Leu Thr Lys Thr Glu Phe Glu Asp Ile Ile Lys Gln Leu Val Lys Arg 
                85                  90                  95      


Trp Ala Glu Leu Pro Lys Asp Thr Phe Trp Ser Tyr Phe Ser Gln Val 
            100                 105                 110         


Gln Glu Ile Met Trp Thr Phe Asn Asp Ile Leu Arg Lys Phe Cys Lys 
        115                 120                 125             


Asp Ile Val Ser Asn Lys Lys Leu Met Lys Lys Leu Gln Glu Ser Arg 
    130                 135                 140                 


Phe Asp Val Val Leu Ala Asp Ala Val Phe Pro Phe Gly Glu Leu Leu 
145                 150                 155                 160 


Ala Glu Leu Leu Lys Ile Pro Phe Val Tyr Ser Leu Arg Phe Ser Pro 
                165                 170                 175     


Gly Tyr Ala Ile Glu Lys His Ser Gly Gly Leu Leu Phe Pro Pro Ser 
            180                 185                 190         


Tyr Val Pro Val Val Met Ser Glu Leu Ser Asp Gln Met Thr Phe Ile 
        195                 200                 205             


Glu Arg Val Lys Asn Met Ile Tyr Val Leu Tyr Phe Glu Phe Trp Phe 
    210                 215                 220                 


Gln Ile Phe Asp Met Lys Lys Trp Asp Gln Phe Tyr Ser Glu Val Leu 
225                 230                 235                 240 


Gly Arg Pro Thr Thr Leu Ser Glu Thr Met Ala Lys Ala Asp Ile Trp 
                245                 250                 255     


Leu Ile Arg Asn Tyr Trp Asp Phe Gln Phe Pro His Pro Leu Leu Pro 
            260                 265                 270         


Asn Val Glu Phe Val Gly Gly Leu His Cys Lys Pro Ala Lys Pro Leu 
        275                 280                 285             


Pro Lys Glu Met Glu Glu Phe Val Gln Ser Ser Gly Glu Asn Gly Val 
    290                 295                 300                 


Val Val Phe Ser Leu Gly Ser Met Val Ser Asn Thr Ser Glu Glu Arg 
305                 310                 315                 320 


Ala Asn Val Ile Ala Ser Ala Leu Ala Lys Ile Pro Gln Lys Val Leu 
                325                 330                 335     


Trp Arg Phe Asp Gly Asn Lys Pro Asp Thr Leu Gly Leu Asn Thr Arg 
            340                 345                 350         


Leu Tyr Lys Trp Ile Pro Gln Asn Asp Leu Leu Gly His Pro Lys Thr 
        355                 360                 365             


Arg Ala Phe Ile Thr His Gly Gly Ala Asn Gly Ile Tyr Glu Ala Ile 
    370                 375                 380                 


Tyr His Gly Ile Pro Met Val Gly Val Pro Leu Phe Ala Asp Gln Pro 
385                 390                 395                 400 


Asp Asn Ile Ala His Met Lys Ala Lys Gly Ala Ala Val Ser Leu Asp 
                405                 410                 415     


Phe His Thr Met Ser Ser Thr Asp Leu Leu Asn Ala Leu Lys Thr Val 
            420                 425                 430         


Ile Asn Asp Pro Leu Tyr Lys Glu Asn Ala Met Lys Leu Ser Arg Ile 
        435                 440                 445             


His His Asp Gln Pro Val Lys Pro Leu Asp Arg Ala Val Phe Trp Ile 
    450                 455                 460                 


Glu Phe Val Met Arg His Lys Gly Ala Lys His Leu Arg Val Ala Ala 
465                 470                 475                 480 


His Asp Leu Thr Trp Phe Gln Tyr His Ser Leu Asp Val Thr Gly Phe 
                485                 490                 495     


Leu Leu Ala Cys Val Ala Thr Val Ile Phe Ile Ile Thr Lys Cys Leu 
            500                 505                 510         


Phe Cys Val Trp Lys Phe Val Arg Thr Gly Lys Lys Gly Lys Arg Asp 
        515                 520                 525             


<210>  4781
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  4781

Met Leu Lys Lys Pro Leu Ser Ala Val Thr Trp Leu Cys Ile Phe Ile 
1               5                   10                  15      


Val Ala Phe Val Ser His Pro Ala Trp Leu Gln Lys Leu Ser Lys His 
            20                  25                  30          


Lys Thr Pro Ala Gln Pro Gln Leu Lys Ala Ala Asn Cys Cys Glu Glu 
        35                  40                  45              


Val Lys Glu Leu Lys Ala Gln Val Ala Asn Leu Ser Ser Leu Leu Ser 
    50                  55                  60                  


Glu Leu Asn Lys Lys Gln Glu Arg Asp Trp Val Ser Val Val Met Gln 
65                  70                  75                  80  


Val Met Glu Leu Glu Ser Asn Ser Lys Arg Met Glu Ser Arg Leu Thr 
                85                  90                  95      


Asp Ala Glu Ser Lys Tyr Ser Glu Met Asn Asn Gln Ile Asp Ile Met 
            100                 105                 110         


Gln Leu Gln Ala Ala Gln Thr Val Thr Gln Thr Ser Ala Asp Ala Ile 
        115                 120                 125             


Tyr Asp Cys Ser Ser Leu Tyr Gln Lys Asn Tyr Arg Ile Ser Gly Val 
    130                 135                 140                 


Tyr Lys Leu Pro Pro Asp Asp Phe Leu Gly Ser Pro Glu Leu Glu Val 
145                 150                 155                 160 


Phe Cys Asp Met Glu Thr Ser Gly Gly Gly Trp Thr Ile Ile Gln Arg 
                165                 170                 175     


Arg Lys Ser Gly Leu Val Ser Phe Tyr Arg Asp Trp Lys Gln Tyr Lys 
            180                 185                 190         


Gln Gly Phe Gly Ser Ile Arg Gly Asp Phe Trp Leu Gly Asn Glu His 
        195                 200                 205             


Ile His Arg Leu Ser Arg Gln Pro Thr Arg Leu Arg Val Glu Met Glu 
    210                 215                 220                 


Asp Trp Glu Gly Asn Leu Arg Tyr Ala Glu Tyr Ser His Phe Val Leu 
225                 230                 235                 240 


Gly Asn Glu Leu Asn Ser Tyr Arg Leu Phe Leu Gly Asn Tyr Thr Gly 
                245                 250                 255     


Asn Val Gly Asn Asp Ala Leu Gln Tyr His Asn Asn Thr Ala Phe Ser 
            260                 265                 270         


Thr Lys Asp Lys Asp Asn Asp Asn Cys Leu Asp Lys Cys Ala Gln Leu 
        275                 280                 285             


Arg Lys Gly Gly Tyr Trp Tyr Asn Cys Cys Thr Asp Ser Asn Leu Asn 
    290                 295                 300                 


Gly Val Tyr Tyr Arg Leu Gly Glu His Asn Lys His Leu Asp Gly Ile 
305                 310                 315                 320 


Thr Trp Tyr Gly Trp His Gly Ser Thr Tyr Ser Leu Lys Arg Val Glu 
                325                 330                 335     


Met Lys Ile Arg Pro Glu Asp Phe Lys Pro 
            340                 345     


<210>  4782
<211>  772
<212>  PRT
<213>  Homo sapiens

<400>  4782

Met Asn Cys Tyr Leu Leu Leu Arg Phe Met Leu Gly Ile Pro Leu Leu 
1               5                   10                  15      


Trp Pro Cys Leu Gly Ala Thr Glu Asn Ser Gln Thr Lys Lys Val Lys 
            20                  25                  30          


Gln Pro Val Arg Ser His Leu Arg Val Lys Arg Gly Trp Val Trp Asn 
        35                  40                  45              


Gln Phe Phe Val Pro Glu Glu Met Asn Thr Thr Ser His His Ile Gly 
    50                  55                  60                  


Gln Leu Arg Ser Asp Leu Asp Asn Gly Asn Asn Ser Phe Gln Tyr Lys 
65                  70                  75                  80  


Leu Leu Gly Ala Gly Ala Gly Ser Thr Phe Ile Ile Asp Glu Arg Thr 
                85                  90                  95      


Gly Asp Ile Tyr Ala Ile Gln Lys Leu Asp Arg Glu Glu Arg Ser Leu 
            100                 105                 110         


Tyr Ile Leu Arg Ala Gln Val Ile Asp Ile Ala Thr Gly Arg Ala Val 
        115                 120                 125             


Glu Pro Glu Ser Glu Phe Val Ile Lys Val Ser Asp Ile Asn Asp Asn 
    130                 135                 140                 


Glu Pro Lys Phe Leu Asp Glu Pro Tyr Glu Ala Ile Val Pro Glu Met 
145                 150                 155                 160 


Ser Pro Glu Gly Thr Leu Val Ile Gln Val Thr Ala Ser Asp Ala Asp 
                165                 170                 175     


Asp Pro Ser Ser Gly Asn Asn Ala Arg Leu Leu Tyr Ser Leu Leu Gln 
            180                 185                 190         


Gly Gln Pro Tyr Phe Ser Val Glu Pro Thr Thr Gly Val Ile Arg Ile 
        195                 200                 205             


Ser Ser Lys Met Asp Arg Glu Leu Gln Asp Glu Tyr Trp Val Ile Ile 
    210                 215                 220                 


Gln Ala Lys Asp Met Ile Gly Gln Pro Gly Ala Leu Ser Gly Thr Thr 
225                 230                 235                 240 


Ser Val Leu Ile Lys Leu Ser Asp Val Asn Asp Asn Lys Pro Ile Phe 
                245                 250                 255     


Lys Glu Ser Leu Tyr Arg Leu Thr Val Ser Glu Ser Ala Pro Thr Gly 
            260                 265                 270         


Thr Ser Ile Gly Thr Ile Met Ala Tyr Asp Asn Asp Ile Gly Glu Asn 
        275                 280                 285             


Ala Glu Met Asp Tyr Ser Ile Glu Glu Asp Asp Ser Gln Thr Phe Asp 
    290                 295                 300                 


Ile Ile Thr Asn His Glu Thr Gln Glu Gly Ile Val Ile Leu Lys Lys 
305                 310                 315                 320 


Lys Val Asp Phe Glu His Gln Asn His Tyr Gly Ile Arg Ala Lys Val 
                325                 330                 335     


Lys Asn His His Val Pro Glu Gln Leu Met Lys Tyr His Thr Glu Ala 
            340                 345                 350         


Ser Thr Thr Phe Ile Lys Ile Gln Val Glu Asp Val Asp Glu Pro Pro 
        355                 360                 365             


Leu Phe Leu Leu Pro Tyr Tyr Val Phe Glu Val Phe Glu Glu Thr Pro 
    370                 375                 380                 


Gln Gly Ser Phe Val Gly Val Val Ser Ala Thr Asp Pro Asp Asn Arg 
385                 390                 395                 400 


Lys Ser Pro Ile Arg Tyr Ser Ile Thr Arg Ser Lys Val Phe Asn Ile 
                405                 410                 415     


Asn Asp Asn Gly Thr Ile Thr Thr Ser Asn Ser Leu Asp Arg Glu Ile 
            420                 425                 430         


Ser Ala Trp Tyr Asn Leu Ser Ile Thr Ala Thr Glu Lys Tyr Asn Ile 
        435                 440                 445             


Glu Gln Ile Ser Ser Ile Pro Leu Tyr Val Gln Val Leu Asn Ile Asn 
    450                 455                 460                 


Asp His Ala Pro Glu Phe Ser Gln Tyr Tyr Glu Thr Tyr Val Cys Glu 
465                 470                 475                 480 


Asn Ala Gly Ser Gly Gln Val Ile Gln Thr Ile Ser Ala Val Asp Arg 
                485                 490                 495     


Asp Glu Ser Ile Glu Glu His His Phe Tyr Phe Asn Leu Ser Val Glu 
            500                 505                 510         


Asp Thr Asn Asn Ser Ser Phe Thr Ile Ile Asp Asn Gln Asp Asn Thr 
        515                 520                 525             


Ala Val Ile Leu Thr Asn Arg Thr Gly Phe Asn Leu Gln Glu Glu Pro 
    530                 535                 540                 


Val Phe Tyr Ile Ser Ile Leu Ile Ala Asp Asn Gly Ile Pro Ser Leu 
545                 550                 555                 560 


Thr Ser Thr Asn Thr Leu Thr Ile His Val Cys Asp Cys Gly Asp Ser 
                565                 570                 575     


Gly Ser Thr Gln Thr Cys Gln Tyr Gln Glu Leu Val Leu Ser Met Gly 
            580                 585                 590         


Phe Lys Thr Glu Val Ile Ile Ala Ile Leu Ile Cys Ile Met Ile Ile 
        595                 600                 605             


Phe Gly Phe Ile Phe Leu Thr Leu Gly Leu Lys Gln Arg Arg Lys Gln 
    610                 615                 620                 


Ile Leu Phe Pro Glu Lys Ser Glu Asp Phe Arg Glu Asn Ile Phe Gln 
625                 630                 635                 640 


Tyr Asp Asp Glu Gly Gly Gly Glu Glu Asp Thr Glu Ala Phe Asp Ile 
                645                 650                 655     


Ala Glu Leu Arg Ser Ser Thr Ile Met Arg Glu Arg Lys Thr Arg Lys 
            660                 665                 670         


Thr Thr Ser Ala Glu Ile Arg Ser Leu Tyr Arg Gln Ser Leu Gln Val 
        675                 680                 685             


Gly Pro Asp Ser Ala Ile Phe Arg Lys Phe Ile Leu Glu Lys Leu Glu 
    690                 695                 700                 


Glu Ala Asn Thr Asp Pro Cys Ala Pro Pro Phe Asp Ser Leu Gln Thr 
705                 710                 715                 720 


Tyr Ala Phe Glu Gly Thr Gly Ser Leu Ala Gly Ser Leu Ser Ser Leu 
                725                 730                 735     


Glu Ser Ala Val Ser Asp Gln Asp Glu Ser Tyr Asp Tyr Leu Asn Glu 
            740                 745                 750         


Leu Gly Pro Arg Phe Lys Arg Leu Ala Cys Met Phe Gly Ser Ala Val 
        755                 760                 765             


Gln Ser Asn Asn 
    770         


<210>  4783
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  4783

Met Ala Lys Leu Leu Ser Cys Val Leu Gly Pro Arg Leu Tyr Lys Ile 
1               5                   10                  15      


Tyr Arg Glu Arg Asp Ser Glu Arg Ala Pro Ala Ser Val Pro Glu Thr 
            20                  25                  30          


Pro Thr Ala Val Thr Ala Pro His Ser Ser Ser Trp Asp Thr Tyr Tyr 
        35                  40                  45              


Gln Pro Arg Ala Leu Glu Lys His Ala Asp Ser Ile Leu Ala Leu Ala 
    50                  55                  60                  


Ser Val Phe Trp Ser Ile Ser Tyr Tyr Ser Ser Pro Phe Ala Phe Phe 
65                  70                  75                  80  


Tyr Leu Tyr Arg Lys Gly Tyr Leu Ser Leu Ser Lys Val Val Pro Phe 
                85                  90                  95      


Ser His Tyr Ala Gly Thr Leu Leu Leu Leu Leu Ala Gly Val Ala Cys 
            100                 105                 110         


Leu Arg Gly Ile Gly Arg Trp Thr Asn Pro Gln Tyr Arg Gln Phe Ile 
        115                 120                 125             


Thr Ile Leu Glu Ala Thr His Arg Asn Gln Ser Ser Glu Asn Lys Arg 
    130                 135                 140                 


Gln Leu Ala Asn Tyr Asn Phe Asp Phe Arg Ser Trp Pro Val Asp Phe 
145                 150                 155                 160 


His Trp Glu Glu Pro Ser Ser Arg Lys Glu Ser Arg Gly Gly Pro Ser 
                165                 170                 175     


Arg Arg Gly Val Ala Leu Leu Arg Pro Glu Pro Leu His Arg Gly Thr 
            180                 185                 190         


Ala Asp Thr Leu Leu Asn Arg Val Lys Lys Leu Pro Cys Gln Ile Thr 
        195                 200                 205             


Ser Tyr Leu Val Ala His Thr Leu Gly Arg Arg Met Leu Tyr Pro Gly 
    210                 215                 220                 


Ser Val Tyr Leu Leu Gln Lys Ala Leu Met Pro Val Leu Leu Gln Gly 
225                 230                 235                 240 


Gln Ala Arg Leu Val Glu Glu Cys Asn Gly Arg Arg Ala Lys Leu Leu 
                245                 250                 255     


Ala Cys Asp Gly Asn Glu Ile Asp Thr Met Phe Val Asp Arg Arg Gly 
            260                 265                 270         


Thr Ala Glu Pro Gln Gly Gln Lys Leu Val Ile Cys Cys Glu Gly Asn 
        275                 280                 285             


Ala Gly Phe Tyr Glu Val Gly Cys Val Ser Thr Pro Leu Glu Ala Gly 
    290                 295                 300                 


Tyr Ser Val Leu Gly Trp Asn His Pro Gly Phe Ala Gly Ser Thr Gly 
305                 310                 315                 320 


Val Pro Phe Pro Gln Asn Glu Ala Asn Ala Met Asp Val Val Val Gln 
                325                 330                 335     


Phe Ala Ile His Arg Leu Gly Phe Gln Pro Gln Asp Ile Ile Ile Tyr 
            340                 345                 350         


Ala Trp Ser Ile Gly Gly Phe Thr Ala Thr Trp Ala Ala Met Ser Tyr 
        355                 360                 365             


Pro Asp Val Ser Ala Met Ile Leu Asp Ala Ser Phe Asp Asp Leu Val 
    370                 375                 380                 


Pro Leu Ala Leu Lys Val Met Pro Asp Ser Trp Arg Gly Leu Val Thr 
385                 390                 395                 400 


Arg Thr Val Arg Gln His Leu Asn Leu Asn Asn Ala Glu Gln Leu Cys 
                405                 410                 415     


Arg Tyr Gln Gly Pro Val Leu Leu Ile Arg Arg Thr Lys Asp Glu Ile 
            420                 425                 430         


Ile Thr Thr Thr Val Pro Glu Asp Ile Met Ser Asn Arg Gly Asn Asp 
        435                 440                 445             


Leu Leu Leu Lys Leu Leu Gln His Arg Tyr Pro Arg Val Met Ala Glu 
    450                 455                 460                 


Glu Gly Leu Arg Val Val Arg Gln Trp Leu Glu Ala Ser Ser Gln Leu 
465                 470                 475                 480 


Glu Glu Ala Ser Ile Tyr Ser Arg Trp Glu Val Glu Glu Asp Trp Cys 
                485                 490                 495     


Leu Ser Val Leu Arg Ser Tyr Gln Ala Glu His Gly Pro Asp Phe Pro 
            500                 505                 510         


Trp Ser Val Gly Glu Asp Met Ser Ala Asp Gly Arg Arg Gln Leu Ala 
        515                 520                 525             


Leu Phe Leu Ala Arg Lys His Leu His Asn Phe Glu Ala Thr His Cys 
    530                 535                 540                 


Thr Pro Leu Pro Ala Gln Asn Phe Gln Met Pro Trp His Leu 
545                 550                 555             


<210>  4784
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  4784

Met Phe Phe Leu Tyr Thr Asp Phe Phe Leu Ser Leu Val Ala Val Pro 
1               5                   10                  15      


Ala Ala Ala Pro Val Cys Gln Pro Lys Ser Ala Thr Asn Gly Gln Pro 
            20                  25                  30          


Pro Ala Pro Ala Pro Thr Pro Thr Pro Arg Leu Ser Ile Ser Ser Arg 
        35                  40                  45              


Ala Thr Val Val Ala Arg Met Glu Gly Thr Ser Gln Gly Gly Leu Gln 
    50                  55                  60                  


Thr Val Met Lys Trp Lys Thr Val Val Ala Ile Phe Val Val Val Val 
65                  70                  75                  80  


Val Tyr Leu Val Thr Gly Gly Leu Val Phe Arg Ala Leu Glu Gln Pro 
                85                  90                  95      


Phe Glu Ser Ser Gln Lys Asn Thr Ile Ala Leu Glu Lys Ala Glu Phe 
            100                 105                 110         


Leu Arg Asp His Val Cys Val Ser Pro Gln Glu Leu Glu Thr Leu Ile 
        115                 120                 125             


Gln His Ala Leu Asp Ala Asp Asn Ala Gly Val Ser Pro Ile Gly Asn 
    130                 135                 140                 


Ser Ser Asn Asn Ser Ser His Trp Asp Leu Gly Ser Ala Phe Phe Phe 
145                 150                 155                 160 


Ala Gly Thr Val Ile Thr Thr Ile Gly Tyr Gly Asn Ile Ala Pro Ser 
                165                 170                 175     


Thr Glu Gly Gly Lys Ile Phe Cys Ile Leu Tyr Ala Ile Phe Gly Ile 
            180                 185                 190         


Pro Leu Phe Gly Phe Leu Leu Ala Gly Ile Gly Asp Gln Leu Gly Thr 
        195                 200                 205             


Ile Phe Gly Lys Ser Ile Ala Arg Val Glu Lys Val Phe Arg Lys Lys 
    210                 215                 220                 


Gln Val Ser Gln Thr Lys Ile Arg Val Ile Ser Thr Ile Leu Phe Ile 
225                 230                 235                 240 


Leu Ala Gly Cys Ile Val Phe Val Thr Ile Pro Ala Val Ile Phe Lys 
                245                 250                 255     


Tyr Ile Glu Gly Trp Thr Ala Leu Glu Ser Ile Tyr Phe Val Val Val 
            260                 265                 270         


Thr Leu Thr Thr Val Gly Phe Gly Asp Phe Val Ala Gly Gly Asn Ala 
        275                 280                 285             


Gly Ile Asn Tyr Arg Glu Trp Tyr Lys Pro Leu Val Trp Phe Trp Ile 
    290                 295                 300                 


Leu Val Gly Leu Ala Tyr Phe Ala Ala Val Leu Ser Met Ile Gly Asp 
305                 310                 315                 320 


Trp Leu Arg Val Leu Ser Lys Lys Thr Lys Glu Glu Val Gly Glu Ile 
                325                 330                 335     


Lys Ala His Ala Ala Glu Trp Lys Ala Asn Val Thr Ala Glu Phe Arg 
            340                 345                 350         


Glu Thr Arg Arg Arg Leu Ser Val Glu Ile His Asp Lys Leu Gln Arg 
        355                 360                 365             


Ala Ala Thr Ile Arg Ser Met Glu Arg Arg Arg Leu Gly Leu Asp Gln 
    370                 375                 380                 


Arg Ala His Ser Leu Asp Met Leu Ser Pro Glu Lys Arg Ser Val Phe 
385                 390                 395                 400 


Ala Ala Leu Asp Thr Gly Arg Phe Lys Ala Ser Ser Gln Glu Ser Ile 
                405                 410                 415     


Asn Asn Arg Pro Asn Asn Leu Arg Leu Lys Gly Pro Glu Gln Leu Asn 
            420                 425                 430         


Lys His Gly Gln Gly Ala Ser Glu Asp Asn Ile Ile Asn Lys Phe Gly 
        435                 440                 445             


Ser Thr Ser Arg Leu Thr Lys Arg Lys Asn Lys Asp Leu Lys Lys Thr 
    450                 455                 460                 


Leu Pro Glu Asp Val Gln Lys Ile Tyr Lys Thr Phe Arg Asn Tyr Ser 
465                 470                 475                 480 


Leu Asp Glu Glu Lys Lys Glu Glu Glu Thr Glu Lys Met Cys Asn Ser 
                485                 490                 495     


Asp Asn Ser Ser Thr Ala Met Leu Thr Asp Cys Ile Gln Gln His Ala 
            500                 505                 510         


Glu Leu Glu Asn Gly Met Ile Pro Thr Asp Thr Lys Asp Arg Glu Pro 
        515                 520                 525             


Glu Asn Asn Ser Leu Leu Glu Asp Arg Asn 
    530                 535             


<210>  4785
<211>  783
<212>  PRT
<213>  Homo sapiens

<400>  4785

Met Arg Trp Gln Cys Gly Thr Arg Phe Arg Gly Leu Arg Pro Ala Val 
1               5                   10                  15      


Ala Pro Trp Thr Ala Leu Leu Ala Leu Gly Leu Pro Gly Trp Val Leu 
            20                  25                  30          


Ala Val Ser Ala Thr Ala Ala Ala Val Val Pro Glu Gln His Ala Ser 
        35                  40                  45              


Val Ala Gly Gln His Pro Leu Asp Trp Leu Leu Thr Asp Arg Gly Pro 
    50                  55                  60                  


Phe His Arg Ala Gln Glu Tyr Ala Asp Phe Met Glu Arg Tyr Arg Gln 
65                  70                  75                  80  


Gly Phe Thr Thr Arg Tyr Arg Ile Tyr Arg Glu Phe Ala Arg Trp Lys 
                85                  90                  95      


Val Asn Asn Leu Ala Leu Glu Arg Lys Asp Phe Phe Ser Leu Pro Leu 
            100                 105                 110         


Pro Leu Ala Pro Glu Phe Ile Arg Asn Ile Arg Leu Leu Gly Arg Arg 
        115                 120                 125             


Pro Asn Leu Gln Gln Val Thr Glu Asn Leu Ile Lys Lys Tyr Gly Thr 
    130                 135                 140                 


His Phe Leu Leu Ser Ala Thr Leu Gly Gly Glu Glu Ser Leu Thr Ile 
145                 150                 155                 160 


Phe Val Asp Lys Gln Lys Leu Gly Arg Lys Thr Glu Thr Thr Gly Gly 
                165                 170                 175     


Ala Ser Ile Ile Gly Gly Ser Gly Asn Ser Thr Ala Val Ser Leu Glu 
            180                 185                 190         


Thr Leu His Gln Leu Ala Ala Ser Tyr Phe Ile Asp Arg Glu Ser Thr 
        195                 200                 205             


Leu Arg Arg Leu His His Ile Gln Ile Ala Thr Gly Ala Ile Lys Val 
    210                 215                 220                 


Thr Glu Thr Arg Thr Gly Pro Leu Gly Cys Ser Asn Tyr Asp Asn Leu 
225                 230                 235                 240 


Asp Ser Val Ser Ser Val Leu Val Gln Ser Pro Glu Asn Lys Val Gln 
                245                 250                 255     


Leu Leu Gly Leu Gln Val Leu Leu Pro Glu Tyr Leu Arg Glu Arg Phe 
            260                 265                 270         


Val Ala Ala Ala Leu Ser Tyr Ile Thr Cys Ser Ser Glu Gly Glu Leu 
        275                 280                 285             


Val Cys Lys Glu Asn Asp Cys Trp Cys Lys Cys Ser Pro Thr Phe Pro 
    290                 295                 300                 


Glu Cys Asn Cys Pro Asp Ala Asp Ile Gln Ala Met Glu Asp Ser Leu 
305                 310                 315                 320 


Leu Gln Ile Gln Asp Ser Trp Ala Thr His Asn Arg Gln Phe Glu Glu 
                325                 330                 335     


Ser Glu Glu Phe Gln Ala Leu Leu Lys Arg Leu Pro Asp Asp Arg Phe 
            340                 345                 350         


Leu Asn Ser Thr Ala Ile Ser Gln Phe Trp Ala Met Asp Thr Ser Leu 
        355                 360                 365             


Gln His Arg Tyr Gln Gln Leu Gly Ala Gly Leu Lys Val Leu Phe Lys 
    370                 375                 380                 


Lys Thr His Arg Ile Leu Arg Arg Leu Phe Asn Leu Cys Lys Arg Cys 
385                 390                 395                 400 


His Arg Gln Pro Arg Phe Arg Leu Pro Lys Glu Arg Ser Leu Ser Tyr 
                405                 410                 415     


Trp Trp Asn Arg Ile Gln Ser Leu Leu Tyr Cys Gly Glu Ser Thr Phe 
            420                 425                 430         


Pro Gly Thr Phe Leu Glu Gln Ser His Ser Cys Thr Cys Pro Tyr Asp 
        435                 440                 445             


Gln Ser Ser Cys Gln Gly Pro Ile Pro Cys Ala Leu Gly Glu Gly Pro 
    450                 455                 460                 


Ala Cys Ala His Cys Ala Pro Asp Asn Ser Thr Arg Cys Gly Ser Cys 
465                 470                 475                 480 


Asn Pro Gly Tyr Val Leu Ala Gln Gly Leu Cys Arg Pro Glu Val Ala 
                485                 490                 495     


Glu Ser Leu Glu Asn Phe Leu Gly Leu Glu Thr Asp Leu Gln Asp Leu 
            500                 505                 510         


Glu Leu Lys Tyr Leu Leu Gln Lys Gln Asp Ser Arg Ile Glu Val His 
        515                 520                 525             


Ser Ile Phe Ile Ser Asn Asp Met Arg Leu Gly Ser Trp Phe Asp Pro 
    530                 535                 540                 


Ser Trp Arg Lys Arg Met Leu Leu Thr Leu Lys Ser Asn Lys Tyr Lys 
545                 550                 555                 560 


Pro Gly Leu Val His Val Met Leu Ala Leu Ser Leu Gln Ile Cys Leu 
                565                 570                 575     


Thr Lys Asn Ser Thr Leu Glu Pro Val Met Ala Ile Tyr Val Asn Pro 
            580                 585                 590         


Phe Gly Gly Ser His Ser Glu Ser Trp Phe Met Pro Val Asn Glu Gly 
        595                 600                 605             


Ser Phe Pro Asp Trp Glu Arg Thr Asn Val Asp Ala Ala Ala Gln Cys 
    610                 615                 620                 


Gln Asn Trp Thr Ile Thr Leu Gly Asn Arg Trp Lys Thr Phe Phe Glu 
625                 630                 635                 640 


Thr Val His Val Tyr Leu Arg Ser Arg Ile Lys Ser Leu Asp Asp Ser 
                645                 650                 655     


Ser Asn Glu Thr Ile Tyr Tyr Glu Pro Leu Glu Met Thr Asp Pro Ser 
            660                 665                 670         


Lys Asn Leu Gly Tyr Met Lys Ile Asn Thr Leu Gln Val Phe Gly Tyr 
        675                 680                 685             


Ser Leu Pro Phe Asp Pro Asp Ala Ile Arg Asp Leu Ile Leu Gln Leu 
    690                 695                 700                 


Asp Tyr Pro Tyr Thr Gln Gly Ser Gln Asp Ser Ala Leu Leu Gln Leu 
705                 710                 715                 720 


Ile Glu Leu Arg Asp Arg Val Asn Gln Leu Ser Pro Pro Gly Lys Val 
                725                 730                 735     


Arg Leu Asp Leu Phe Ser Cys Leu Leu Arg His Arg Leu Lys Leu Ala 
            740                 745                 750         


Asn Asn Glu Val Gly Arg Ile Gln Ser Ser Leu Arg Ala Phe Asn Ser 
        755                 760                 765             


Lys Leu Pro Asn Pro Val Glu Tyr Glu Thr Gly Lys Leu Cys Ser 
    770                 775                 780             


<210>  4786
<211>  84
<212>  PRT
<213>  Homo sapiens

<400>  4786

Met Ala Leu Ser Ser Gln Ile Trp Ala Ala Cys Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ala Ser Leu Thr Ser Gly Ser Val Phe Pro Gln Gln Thr Gly 
            20                  25                  30          


Gln Leu Ala Glu Leu Gln Pro Gln Asp Arg Ala Gly Ala Arg Ala Ser 
        35                  40                  45              


Trp Met Pro Met Phe Gln Arg Arg Arg Arg Arg Asp Thr His Phe Pro 
    50                  55                  60                  


Ile Cys Ile Phe Cys Cys Gly Cys Cys His Arg Ser Lys Cys Gly Met 
65                  70                  75                  80  


Cys Cys Lys Thr 
                


<210>  4787
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  4787

Met Asp Phe Leu His Arg Asn Gly Val Leu Ile Ile Gln His Leu Gln 
1               5                   10                  15      


Lys Asp Tyr Arg Ala Tyr Tyr Thr Phe Leu Asn Phe Met Ser Asn Val 
            20                  25                  30          


Gly Asp Pro Arg Asn Ile Phe Phe Ile Tyr Phe Pro Leu Cys Phe Gln 
        35                  40                  45              


Phe Asn Gln Thr Val Gly Thr Lys Met Ile Trp Val Ala Val Ile Gly 
    50                  55                  60                  


Asp Trp Leu Asn Leu Ile Phe Lys Trp Ile Leu Phe Gly His Arg Pro 
65                  70                  75                  80  


Tyr Trp Trp Val Gln Glu Thr Gln Ile Tyr Pro Asn His Ser Ser Pro 
                85                  90                  95      


Cys Leu Glu Gln Phe Pro Thr Thr Cys Glu Thr Gly Pro Gly Ser Pro 
            100                 105                 110         


Ser Gly His Ala Met Gly Ala Ser Cys Val Trp Tyr Val Met Val Thr 
        115                 120                 125             


Ala Ala Leu Ser His Thr Val Cys Gly Met Asp Lys Phe Ser Ile Thr 
    130                 135                 140                 


Leu His Arg Leu Thr Trp Ser Phe Leu Trp Ser Val Phe Trp Leu Ile 
145                 150                 155                 160 


Gln Ile Ser Val Cys Ile Ser Arg Val Phe Ile Ala Thr His Phe Pro 
                165                 170                 175     


His Gln Val Ile Leu Gly Val Ile Gly Gly Met Leu Val Ala Glu Ala 
            180                 185                 190         


Phe Glu His Thr Pro Gly Ile Gln Thr Ala Ser Leu Gly Thr Tyr Leu 
        195                 200                 205             


Lys Thr Asn Leu Phe Leu Phe Leu Phe Ala Val Gly Phe Tyr Leu Leu 
    210                 215                 220                 


Leu Arg Val Leu Asn Ile Asp Leu Leu Trp Ser Val Pro Ile Ala Lys 
225                 230                 235                 240 


Lys Trp Cys Ala Asn Pro Asp Trp Ile His Ile Asp Thr Thr Pro Phe 
                245                 250                 255     


Ala Gly Leu Val Arg Asn Leu Gly Val Leu Phe Gly Leu Gly Phe Ala 
            260                 265                 270         


Ile Asn Ser Glu Met Phe Leu Leu Ser Cys Arg Gly Gly Asn Asn Tyr 
        275                 280                 285             


Thr Leu Ser Phe Arg Leu Leu Cys Ala Leu Thr Ser Leu Thr Ile Leu 
    290                 295                 300                 


Gln Leu Tyr His Phe Leu Gln Ile Pro Thr His Glu Glu His Leu Phe 
305                 310                 315                 320 


Tyr Val Leu Ser Phe Cys Lys Ser Ala Ser Ile Pro Leu Thr Val Val 
                325                 330                 335     


Ala Phe Ile Pro Tyr Ser Val His Met Leu Met Lys Gln Ser Gly Lys 
            340                 345                 350         


Lys Ser Gln 
        355 


<210>  4788
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  4788

Met Ala Gly Ser Pro Thr Cys Leu Thr Leu Ile Tyr Ile Leu Trp Gln 
1               5                   10                  15      


Leu Thr Gly Ser Ala Ala Ser Gly Pro Val Lys Glu Leu Val Gly Ser 
            20                  25                  30          


Val Gly Gly Ala Val Thr Phe Pro Leu Lys Ser Lys Val Lys Gln Val 
        35                  40                  45              


Asp Ser Ile Val Trp Thr Phe Asn Thr Thr Pro Leu Val Thr Ile Gln 
    50                  55                  60                  


Pro Glu Gly Gly Thr Ile Ile Val Thr Gln Asn Arg Asn Arg Glu Arg 
65                  70                  75                  80  


Val Asp Phe Pro Asp Gly Gly Tyr Ser Leu Lys Leu Ser Lys Leu Lys 
                85                  90                  95      


Lys Asn Asp Ser Gly Ile Tyr Tyr Val Gly Ile Tyr Ser Ser Ser Leu 
            100                 105                 110         


Gln Gln Pro Ser Thr Gln Glu Tyr Val Leu His Val Tyr Glu His Leu 
        115                 120                 125             


Ser Lys Pro Lys Val Thr Met Gly Leu Gln Ser Asn Lys Asn Gly Thr 
    130                 135                 140                 


Cys Val Thr Asn Leu Thr Cys Cys Met Glu His Gly Glu Glu Asp Val 
145                 150                 155                 160 


Ile Tyr Thr Trp Lys Ala Leu Gly Gln Ala Ala Asn Glu Ser His Asn 
                165                 170                 175     


Gly Ser Ile Leu Pro Ile Ser Trp Arg Trp Gly Glu Ser Asp Met Thr 
            180                 185                 190         


Phe Ile Cys Val Ala Arg Asn Pro Val Ser Arg Asn Phe Ser Ser Pro 
        195                 200                 205             


Ile Leu Ala Arg Lys Leu Cys Glu Gly Ala Ala Asp Asp Pro Asp Ser 
    210                 215                 220                 


Ser Met Val Leu Leu Cys Leu Leu Leu Val Pro Leu Leu Leu Ser Leu 
225                 230                 235                 240 


Phe Val Leu Gly Leu Phe Leu Trp Phe Leu Lys Arg Glu Arg Gln Glu 
                245                 250                 255     


Glu Tyr Ile Glu Glu Lys Lys Arg Val Asp Ile Cys Arg Glu Thr Pro 
            260                 265                 270         


Asn Ile Cys Pro His Ser Gly Glu Asn Thr Glu Tyr Asp Thr Ile Pro 
        275                 280                 285             


His Thr Asn Arg Thr Ile Leu Lys Glu Asp Pro Ala Asn Thr Val Tyr 
    290                 295                 300                 


Ser Thr Val Glu Ile Pro Lys Lys Met Glu Asn Pro His Ser Leu Leu 
305                 310                 315                 320 


Thr Met Pro Asp Thr Pro Arg Leu Phe Ala Tyr Glu Asn Val Ile 
                325                 330                 335 


<210>  4789
<211>  1159
<212>  PRT
<213>  Homo sapiens

<400>  4789

Met Cys Gly Pro Ala Met Phe Pro Ala Gly Pro Pro Trp Pro Arg Val 
1               5                   10                  15      


Arg Val Val Gln Val Leu Trp Ala Leu Leu Ala Val Leu Leu Ala Ser 
            20                  25                  30          


Trp Arg Leu Trp Ala Ile Lys Asp Phe Gln Glu Cys Thr Trp Gln Val 
        35                  40                  45              


Val Leu Asn Glu Phe Lys Arg Val Gly Glu Ser Gly Val Ser Asp Ser 
    50                  55                  60                  


Phe Phe Glu Gln Glu Pro Val Asp Thr Val Ser Ser Leu Phe His Met 
65                  70                  75                  80  


Leu Val Asp Ser Pro Ile Asp Pro Ser Glu Lys Tyr Leu Gly Phe Pro 
                85                  90                  95      


Tyr Tyr Leu Lys Ile Asn Tyr Ser Cys Glu Glu Lys Pro Ser Glu Asp 
            100                 105                 110         


Leu Val Arg Met Gly His Leu Thr Gly Leu Lys Pro Leu Val Leu Val 
        115                 120                 125             


Thr Phe Gln Ser Pro Val Asn Phe Tyr Arg Trp Lys Ile Glu Gln Leu 
    130                 135                 140                 


Gln Ile Gln Met Glu Ala Ala Pro Phe Arg Ser Lys Glu Pro Cys Met 
145                 150                 155                 160 


Ala Glu Glu Val Cys Ser Met Ser Trp Tyr Thr Pro Met Pro Ile Lys 
                165                 170                 175     


Lys Gly Ser Val Val Met Arg Val Asp Ile Ser Ser Asn Gly Leu Gly 
            180                 185                 190         


Thr Phe Ile Pro Asp Lys Arg Phe Gln Met Asn Ile Asn Gly Phe Leu 
        195                 200                 205             


Lys Arg Asp Arg Asp Asn Asn Ile Gln Phe Thr Val Gly Glu Glu Leu 
    210                 215                 220                 


Phe Asn Leu Met Pro Gln Tyr Phe Val Gly Val Ser Ser Arg Pro Leu 
225                 230                 235                 240 


Trp His Thr Val Asp Gln Ser Pro Val Leu Ile Leu Gly Gly Ile Pro 
                245                 250                 255     


Asn Glu Lys Tyr Val Leu Met Thr Asp Thr Ser Phe Lys Asp Phe Ser 
            260                 265                 270         


Leu Val Glu Leu Ser Ile Asp Ser Cys Trp Val Gly Ser Phe Tyr Cys 
        275                 280                 285             


Pro His Ser Gly Phe Thr Ala Thr Ile Tyr Asp Thr Ile Ala Thr Glu 
    290                 295                 300                 


Ser Thr Leu Phe Ile Arg Gln Asn Gln Leu Val Tyr Tyr Phe Thr Gly 
305                 310                 315                 320 


Thr Tyr Thr Thr Leu Tyr Glu Arg Asn Arg Gly Ser Gly Ser Trp Ile 
                325                 330                 335     


Arg Val Leu Ala Ser Glu Cys Ile Lys Lys Leu Cys Pro Val Tyr Phe 
            340                 345                 350         


His Ser Asn Gly Ser Glu Tyr Ile Met Ala Leu Thr Thr Gly Lys His 
        355                 360                 365             


Glu Gly Tyr Val His Phe Gly Thr Ile Arg Asp Gly Gln Val Ser Phe 
    370                 375                 380                 


Glu Met Leu Pro Arg Gln Trp Ser Val Cys Glu Gln Ile Gly Val Thr 
385                 390                 395                 400 


Thr Cys Ser Ile Ile Trp Ser Glu Tyr Ile Ala Gly Glu Tyr Thr Leu 
                405                 410                 415     


Leu Leu Leu Val Glu Ser Gly Tyr Gly Asn Ala Ser Lys Arg Phe Gln 
            420                 425                 430         


Val Val Ser Tyr Asn Thr Ala Ser Asp Asp Leu Glu Leu Leu Tyr His 
        435                 440                 445             


Ile Pro Glu Phe Ile Pro Glu Ala Arg Gly Leu Glu Phe Leu Met Ile 
    450                 455                 460                 


Leu Gly Thr Glu Ser Tyr Thr Ser Thr Ala Met Ala Pro Lys Gly Ile 
465                 470                 475                 480 


Phe Cys Asn Pro Tyr Asn Asn Leu Ile Phe Ile Trp Gly Asn Phe Leu 
                485                 490                 495     


Leu Gln Ser Ser Asn Lys Glu Asn Phe Ile Tyr Leu Ala Asp Phe Pro 
            500                 505                 510         


Lys Glu Leu Ser Ile Lys Tyr Met Ala Arg Ser Phe Arg Gly Ala Val 
        515                 520                 525             


Ala Ile Val Thr Glu Thr Glu Glu Ile Trp Tyr Leu Leu Glu Gly Ser 
    530                 535                 540                 


Tyr Arg Val Tyr Gln Leu Phe Pro Ser Lys Gly Trp Gln Val His Ile 
545                 550                 555                 560 


Ser Leu Lys Leu Met Gln Gln Ser Ser Leu Tyr Ala Ser Asn Glu Thr 
                565                 570                 575     


Met Leu Thr Leu Phe Tyr Glu Asp Ser Lys Leu Tyr Gln Leu Val Tyr 
            580                 585                 590         


Leu Met Asn Asn Gln Lys Gly Gln Leu Val Lys Arg Leu Val Pro Val 
        595                 600                 605             


Glu Gln Leu Leu Met Tyr Gln Gln His Thr Ser His Tyr Asp Leu Glu 
    610                 615                 620                 


Arg Lys Gly Gly Tyr Leu Met Leu Ser Phe Ile Asp Phe Cys Pro Phe 
625                 630                 635                 640 


Ser Val Met Arg Leu Arg Ser Leu Pro Ser Pro Gln Arg Tyr Thr Arg 
                645                 650                 655     


Gln Glu Arg Tyr Arg Ala Arg Pro Pro Arg Val Leu Glu Arg Ser Gly 
            660                 665                 670         


Phe His Asn Glu Asn Ser Leu Ala Ile Tyr Gln Gly Leu Val Tyr Tyr 
        675                 680                 685             


Leu Leu Trp Leu His Ser Val Tyr Asp Lys Pro Tyr Ala Asp Pro Val 
    690                 695                 700                 


His Asp Pro Thr Trp Arg Trp Trp Ala Asn Asn Lys Gln Asp Gln Asp 
705                 710                 715                 720 


Tyr Tyr Phe Phe Leu Ala Ser Asn Trp Arg Ser Ala Gly Gly Val Ser 
                725                 730                 735     


Ile Glu Met Asp Ser Tyr Glu Lys Ile Tyr Asn Leu Glu Ser Ala Tyr 
            740                 745                 750         


Glu Leu Pro Glu Arg Ile Phe Leu Asp Lys Gly Thr Glu Tyr Ser Phe 
        755                 760                 765             


Ala Ile Phe Leu Ser Ala Gln Gly His Ser Phe Arg Thr Gln Ser Glu 
    770                 775                 780                 


Leu Gly Thr Ala Phe Gln Leu His Ser Gln Val Asp Val Gly Val Val 
785                 790                 795                 800 


Leu Ala Asp Pro Gly Cys Ile Glu Ala Ser Val Lys Gln Glu Val Leu 
                805                 810                 815     


Ile Asn Arg Asn Ser Val Leu Phe Ser Ile Thr Leu Lys Asp Lys Lys 
            820                 825                 830         


Leu Cys Tyr Asp Gln Gly Ile Ser Gly His His Leu Met Glu Thr Ser 
        835                 840                 845             


Met Thr Val Asn Val Val Gly Ser Ser Gly Leu Cys Phe Gln Glu Thr 
    850                 855                 860                 


His Leu Gly Pro His Met Gln Gly Asn Leu Met Val Pro Val Phe Ile 
865                 870                 875                 880 


Gly Cys Pro Pro Gly Lys Arg Leu Ala Phe Asp Ile Thr Tyr Thr Leu 
                885                 890                 895     


Glu Tyr Ser Arg Leu Lys Asn Lys His Tyr Phe Asp Cys Val Asn Val 
            900                 905                 910         


Asn Pro Glu Met Pro Cys Phe Leu Phe Arg Asp Ile Phe Tyr Pro Phe 
        915                 920                 925             


Phe Leu Ile Gln Asp Leu Val Thr Gly Asp Ser Gly Ser Phe Gln Gly 
    930                 935                 940                 


Ser Tyr Val Leu Leu Val Val Gly Gly Gly Pro Thr Leu Asp Ser Leu 
945                 950                 955                 960 


Lys Asp Tyr Ser Glu Asp Glu Ile Tyr Arg Phe Asn Ser Pro Leu Asp 
                965                 970                 975     


Lys Thr Asn Ser Leu Ile Trp Thr Thr Arg Thr Thr Arg Thr Thr Lys 
            980                 985                 990         


Asp Ser Ala Phe His Ile Met Ser  His Glu Ser Pro Gly  Ile Glu Trp 
        995                 1000                 1005             


Leu Cys  Leu Glu Asn Ala Pro  Cys Tyr Asp Asn Val  Pro Gln Gly 
    1010                 1015                 1020             


Ile Phe  Ala Pro Glu Phe Phe  Phe Lys Val Leu Val  Ser Asn Arg 
    1025                 1030                 1035             


Gly Val  Asp Thr Ser Thr Tyr  Cys Asn Tyr Gln Leu  Thr Phe Leu 
    1040                 1045                 1050             


Leu His  Ile His Gly Leu Pro  Leu Ser Pro Lys Arg  Ala Leu Phe 
    1055                 1060                 1065             


Ile Ile  Met Val Ser Ala Ser  Val Phe Val Gly Leu  Val Ile Phe 
    1070                 1075                 1080             


Tyr Ile  Ala Phe Cys Leu Leu  Trp Pro Leu Val Val  Lys Gly Cys 
    1085                 1090                 1095             


Thr Met  Ile Arg Trp Lys Ile  Asn Asn Leu Ile Ala  Ser Glu Ser 
    1100                 1105                 1110             


Tyr Tyr  Thr Tyr Ala Ser Ile  Ser Gly Ile Ser Ser  Met Pro Ser 
    1115                 1120                 1125             


Leu Arg  His Ser Arg Met Gly  Ser Met Phe Ser Ser  Arg Met Thr 
    1130                 1135                 1140             


Glu Asp  Arg Ala Glu Pro Lys  Glu Ala Val Glu Arg  Gln Leu Met 
    1145                 1150                 1155             


Thr 
    


<210>  4790
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  4790

Met Gly Ala Pro Ala Ala Ser Leu Leu Leu Leu Leu Leu Leu Phe Ala 
1               5                   10                  15      


Cys Cys Trp Ala Pro Gly Gly Ala Asn Leu Ser Gln Asp Gly Tyr Trp 
            20                  25                  30          


Gln Glu Gln Asp Leu Glu Leu Gly Thr Leu Ala Pro Leu Asp Glu Ala 
        35                  40                  45              


Ile Ser Ser Thr Val Trp Ser Ser Pro Asp Met Leu Ala Ser Gln Asp 
    50                  55                  60                  


Ser Gln Pro Trp Thr Ser Asp Glu Thr Val Val Ala Gly Gly Thr Val 
65                  70                  75                  80  


Val Leu Lys Cys Gln Val Lys Asp His Glu Asp Ser Ser Leu Gln Trp 
                85                  90                  95      


Ser Asn Pro Ala Gln Gln Thr Leu Tyr Phe Gly Glu Lys Arg Ala Leu 
            100                 105                 110         


Arg Asp Asn Arg Ile Gln Leu Val Thr Ser Thr Pro His Glu Leu Ser 
        115                 120                 125             


Ile Ser Ile Ser Asn Val Ala Leu Ala Asp Glu Gly Glu Tyr Thr Cys 
    130                 135                 140                 


Ser Ile Phe Thr Met Pro Val Arg Thr Ala Lys Ser Leu Val Thr Val 
145                 150                 155                 160 


Leu Gly Ile Pro Gln Lys Pro Ile Ile Thr Gly Tyr Lys Ser Ser Leu 
                165                 170                 175     


Arg Glu Lys Asp Thr Ala Thr Leu Asn Cys Gln Ser Ser Gly Ser Lys 
            180                 185                 190         


Pro Ala Ala Arg Leu Thr Trp Arg Lys Gly Asp Gln Glu Leu His Gly 
        195                 200                 205             


Glu Pro Thr Arg Ile Gln Glu Asp Pro Asn Gly Lys Thr Phe Thr Val 
    210                 215                 220                 


Ser Ser Ser Val Thr Phe Gln Val Thr Arg Glu Asp Asp Gly Ala Ser 
225                 230                 235                 240 


Ile Val Cys Ser Val Asn His Glu Ser Leu Lys Gly Ala Asp Arg Ser 
                245                 250                 255     


Thr Ser Gln Arg Ile Glu Val Leu Tyr Thr Pro Thr Ala Met Ile Arg 
            260                 265                 270         


Pro Asp Pro Pro His Pro Arg Glu Gly Gln Lys Leu Leu Leu His Cys 
        275                 280                 285             


Glu Gly Arg Gly Asn Pro Val Pro Gln Gln Tyr Leu Trp Glu Lys Glu 
    290                 295                 300                 


Gly Ser Val Pro Pro Leu Lys Met Thr Gln Glu Ser Ala Leu Ile Phe 
305                 310                 315                 320 


Pro Phe Leu Asn Lys Ser Asp Ser Gly Thr Tyr Gly Cys Thr Ala Thr 
                325                 330                 335     


Ser Asn Met Gly Ser Tyr Lys Ala Tyr Tyr Thr Leu Asn Val Asn Asp 
            340                 345                 350         


Pro Ser Pro Val Pro Ser Ser Ser Ser Thr Tyr His Ala Ile Ile Gly 
        355                 360                 365             


Gly Ile Val Ala Phe Ile Val Phe Leu Leu Leu Ile Met Leu Ile Phe 
    370                 375                 380                 


Leu Gly His Tyr Leu Ile Arg His Lys Gly Thr Tyr Leu Thr His Glu 
385                 390                 395                 400 


Ala Lys Gly Ser Asp Asp Ala Pro Asp Ala Asp Thr Ala Ile Ile Asn 
                405                 410                 415     


Ala Glu Gly Gly Gln Ser Gly Gly Asp Asp Lys Lys Glu Tyr Phe Ile 
            420                 425                 430         


<210>  4791
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  4791

Met Gly Cys Trp Gly Arg Asn Arg Gly Arg Leu Leu Cys Met Leu Ala 
1               5                   10                  15      


Leu Thr Phe Met Phe Met Val Leu Glu Val Val Val Ser Arg Val Thr 
            20                  25                  30          


Ser Ser Leu Ala Met Leu Ser Asp Ser Phe His Met Leu Ser Asp Val 
        35                  40                  45              


Leu Ala Leu Val Val Ala Leu Val Ala Glu Arg Phe Ala Arg Arg Thr 
    50                  55                  60                  


His Ala Thr Gln Lys Asn Thr Phe Gly Trp Ile Arg Ala Glu Val Met 
65                  70                  75                  80  


Gly Ala Leu Val Asn Ala Ile Phe Leu Thr Gly Leu Cys Phe Ala Ile 
                85                  90                  95      


Leu Leu Glu Ala Ile Glu Arg Phe Ile Glu Pro His Glu Met Gln Gln 
            100                 105                 110         


Pro Leu Val Val Leu Gly Val Gly Val Ala Gly Leu Leu Val Asn Val 
        115                 120                 125             


Leu Gly Leu Cys Leu Phe His His His Ser Gly Phe Ser Gln Asp Ser 
    130                 135                 140                 


Gly His Gly His Ser His Gly Gly His Gly His Gly His Gly Leu Pro 
145                 150                 155                 160 


Lys Gly Pro Arg Val Lys Ser Thr Arg Pro Gly Ser Ser Asp Ile Asn 
                165                 170                 175     


Val Ala Pro Gly Glu Gln Gly Pro Asp Gln Glu Glu Thr Asn Thr Leu 
            180                 185                 190         


Val Ala Asn Thr Ser Asn Ser Asn Gly Leu Lys Leu Asp Pro Ala Asp 
        195                 200                 205             


Pro Glu Asn Pro Arg Ser Gly Asp Thr Val Glu Val Gln Val Asn Gly 
    210                 215                 220                 


Asn Leu Val Arg Glu Pro Asp His Met Glu Leu Glu Glu Asp Arg Ala 
225                 230                 235                 240 


Gly Gln Leu Asn Met Arg Gly Val Phe Leu His Val Leu Gly Asp Ala 
                245                 250                 255     


Leu Gly Ser Val Ile Val Val Val Asn Ala Leu Val Phe Tyr Phe Ser 
            260                 265                 270         


Trp Lys Gly Cys Ser Glu Gly Asp Phe Cys Val Asn Pro Cys Phe Pro 
        275                 280                 285             


Asp Pro Cys Lys Ala Phe Val Glu Ile Ile Asn Ser Thr His Ala Ser 
    290                 295                 300                 


Val Tyr Glu Ala Gly Pro Cys Trp Val Leu Tyr Leu Asp Pro Thr Leu 
305                 310                 315                 320 


Cys Val Val Met Val Cys Ile Leu Leu Tyr Thr Thr Tyr Pro Leu Leu 
                325                 330                 335     


Lys Glu Ser Ala Leu Ile Leu Leu Gln Thr Val Pro Lys Gln Ile Asp 
            340                 345                 350         


Ile Arg Asn Leu Ile Lys Glu Leu Arg Asn Val Glu Gly Val Glu Glu 
        355                 360                 365             


Val His Glu Leu His Val Trp Gln Leu Ala Gly Ser Arg Ile Ile Ala 
    370                 375                 380                 


Thr Ala His Ile Lys Cys Glu Asp Pro Thr Ser Tyr Met Glu Val Ala 
385                 390                 395                 400 


Lys Thr Ile Lys Asp Val Phe His Asn His Gly Ile His Ala Thr Thr 
                405                 410                 415     


Ile Gln Pro Glu Phe Ala Ser Val Gly Ser Lys Ser Ser Val Val Pro 
            420                 425                 430         


Cys Glu Leu Ala Cys Arg Thr Gln Cys Ala Leu Lys Gln Cys Cys Gly 
        435                 440                 445             


Thr Leu Pro Gln Ala Pro Ser Gly Lys Asp Ala Glu Lys Thr Pro Ala 
    450                 455                 460                 


Val Ser Ile Ser Cys Leu Glu Leu Ser Asn Asn Leu Glu Lys Lys Pro 
465                 470                 475                 480 


Arg Arg Thr Lys Ala Glu Asn Ile Pro Ala Val Val Ile Glu Ile Lys 
                485                 490                 495     


Asn Met Pro Asn Lys Gln Pro Glu Ser Ser Leu 
            500                 505         


<210>  4792
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  4792

Met Ala Ser Ala Gly Met Gln Ile Leu Gly Val Val Leu Thr Leu Leu 
1               5                   10                  15      


Gly Trp Val Asn Gly Leu Val Ser Cys Ala Leu Pro Met Trp Lys Val 
            20                  25                  30          


Thr Ala Phe Ile Gly Asn Ser Ile Val Val Ala Gln Val Val Trp Glu 
        35                  40                  45              


Gly Leu Trp Met Ser Cys Val Val Gln Ser Thr Gly Gln Met Gln Cys 
    50                  55                  60                  


Lys Val Tyr Asp Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala 
65                  70                  75                  80  


Arg Ala Leu Cys Val Ile Ala Leu Leu Val Ala Leu Phe Gly Leu Leu 
                85                  90                  95      


Val Tyr Leu Ala Gly Ala Lys Cys Thr Thr Cys Val Glu Glu Lys Asp 
            100                 105                 110         


Ser Lys Ala Arg Leu Val Leu Thr Ser Gly Ile Val Phe Val Ile Ser 
        115                 120                 125             


Gly Val Leu Thr Leu Ile Pro Val Cys Trp Thr Ala His Ala Ile Ile 
    130                 135                 140                 


Arg Asp Phe Tyr Asn Pro Leu Val Ala Glu Ala Gln Lys Arg Glu Leu 
145                 150                 155                 160 


Gly Ala Ser Leu Tyr Leu Gly Trp Ala Ala Ser Gly Leu Leu Leu Leu 
                165                 170                 175     


Gly Gly Gly Leu Leu Cys Cys Thr Cys Pro Ser Gly Gly Ser Gln Gly 
            180                 185                 190         


Pro Ser His Tyr Met Ala Arg Tyr Ser Thr Ser Ala Pro Ala Ile Ser 
        195                 200                 205             


Arg Gly Pro Ser Glu Tyr Pro Thr Lys Asn Tyr Val 
    210                 215                 220 


<210>  4793
<211>  1137
<212>  PRT
<213>  Homo sapiens

<400>  4793

Met Lys Val Lys Glu Glu Lys Ala Gly Val Gly Lys Leu Asp His Thr 
1               5                   10                  15      


Asn His Arg Arg Arg Phe Pro Asp Gln Lys Glu Cys Pro Pro Ile His 
            20                  25                  30          


Ile Gly Leu Pro Val Pro Thr Tyr Pro Gln Arg Lys Thr Asp Gln Lys 
        35                  40                  45              


Gly His Leu Ser Gly Leu Gln Lys Val His Trp Gly Leu Arg Pro Asp 
    50                  55                  60                  


Gln Pro Gln Gln Glu Leu Thr Gly Pro Gly Ser Gly Ala Ser Ser Gln 
65                  70                  75                  80  


Asp Ser Ser Met Asp Leu Ile Ser Arg Thr Arg Ser Pro Ala Ala Glu 
                85                  90                  95      


Gln Leu Gln Asp Ile Leu Gly Glu Glu Asp Glu Ala Pro Asn Pro Thr 
            100                 105                 110         


Leu Phe Thr Glu Met Asp Thr Leu Gln His Asp Gly Asp Gln Met Glu 
        115                 120                 125             


Trp Lys Glu Ser Ala Arg Trp Ile Lys Phe Glu Glu Lys Val Glu Glu 
    130                 135                 140                 


Gly Gly Glu Arg Trp Ser Lys Pro His Val Ser Thr Leu Ser Leu His 
145                 150                 155                 160 


Ser Leu Phe Glu Leu Arg Thr Cys Leu Gln Thr Gly Thr Val Leu Leu 
                165                 170                 175     


Asp Leu Asp Ser Gly Ser Leu Pro Gln Ile Ile Asp Asp Val Ile Glu 
            180                 185                 190         


Lys Gln Ile Glu Asp Gly Leu Leu Arg Pro Glu Leu Arg Glu Arg Val 
        195                 200                 205             


Ser Tyr Val Leu Leu Arg Arg His Arg His Gln Thr Lys Lys Pro Ile 
    210                 215                 220                 


His Arg Ser Leu Ala Asp Ile Gly Lys Ser Val Ser Thr Thr Asn Arg 
225                 230                 235                 240 


Ser Pro Ala Arg Ser Pro Gly Ala Gly Pro Ser Leu His His Ser Thr 
                245                 250                 255     


Glu Asp Leu Arg Met Arg Gln Ser Ala Asn Tyr Gly Arg Leu Cys His 
            260                 265                 270         


Ala Gln Ser Arg Ser Met Asn Asp Ile Ser Leu Thr Pro Asn Thr Asp 
        275                 280                 285             


Gln Arg Lys Asn Lys Phe Met Lys Lys Ile Pro Lys Asp Ser Glu Ala 
    290                 295                 300                 


Ser Asn Val Leu Val Gly Glu Val Asp Phe Leu Asp Gln Pro Phe Ile 
305                 310                 315                 320 


Ala Phe Val Arg Leu Ile Gln Ser Ala Met Leu Gly Gly Val Thr Glu 
                325                 330                 335     


Val Pro Val Pro Thr Arg Phe Leu Phe Ile Leu Leu Gly Pro Ser Gly 
            340                 345                 350         


Arg Ala Lys Ser Tyr Asn Glu Ile Gly Arg Ala Ile Ala Thr Leu Met 
        355                 360                 365             


Val Asp Asp Leu Phe Ser Asp Val Ala Tyr Lys Ala Arg Asn Arg Glu 
    370                 375                 380                 


Asp Leu Ile Ala Gly Ile Asp Glu Phe Leu Asp Glu Val Ile Val Leu 
385                 390                 395                 400 


Pro Pro Gly Glu Trp Asp Pro Asn Ile Arg Ile Glu Pro Pro Lys Lys 
                405                 410                 415     


Val Pro Ser Ala Asp Lys Arg Lys Ser Val Phe Ser Leu Ala Glu Leu 
            420                 425                 430         


Gly Gln Met Asn Gly Ser Val Gly Gly Gly Gly Gly Ala Pro Gly Gly 
        435                 440                 445             


Gly Asn Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Ala Gly Ser 
    450                 455                 460                 


Gly Gly Ala Gly Gly Thr Ser Ser Gly Asp Asp Gly Glu Met Pro Ala 
465                 470                 475                 480 


Met His Glu Ile Gly Glu Glu Leu Ile Trp Thr Gly Arg Phe Phe Gly 
                485                 490                 495     


Gly Leu Cys Leu Asp Ile Lys Arg Lys Leu Pro Trp Phe Pro Ser Asp 
            500                 505                 510         


Phe Tyr Asp Gly Phe His Ile Gln Ser Ile Ser Ala Ile Leu Phe Ile 
        515                 520                 525             


Tyr Leu Gly Cys Ile Thr Asn Ala Ile Thr Phe Gly Gly Leu Leu Gly 
    530                 535                 540                 


Asp Ala Thr Asp Asn Tyr Gln Gly Val Met Glu Ser Phe Leu Gly Thr 
545                 550                 555                 560 


Ala Met Ala Gly Ser Leu Phe Cys Leu Phe Ser Gly Gln Pro Leu Ile 
                565                 570                 575     


Ile Leu Ser Ser Thr Gly Pro Ile Leu Ile Phe Glu Lys Leu Leu Phe 
            580                 585                 590         


Asp Phe Ser Lys Gly Asn Gly Leu Asp Tyr Met Glu Phe Arg Leu Trp 
        595                 600                 605             


Ile Gly Leu His Ser Ala Val Gln Cys Leu Ile Leu Val Ala Thr Asp 
    610                 615                 620                 


Ala Ser Phe Ile Ile Lys Tyr Ile Thr Arg Phe Thr Glu Glu Gly Phe 
625                 630                 635                 640 


Ser Thr Leu Ile Ser Phe Ile Phe Ile Tyr Asp Ala Ile Lys Lys Met 
                645                 650                 655     


Ile Gly Ala Phe Lys Tyr Tyr Pro Ile Asn Met Asp Phe Lys Pro Asn 
            660                 665                 670         


Phe Ile Thr Thr Tyr Lys Cys Glu Cys Val Ala Pro Asp Thr Val Asn 
        675                 680                 685             


Thr Thr Val Phe Asn Ala Ser Ala Pro Leu Ala Pro Asp Thr Asn Ala 
    690                 695                 700                 


Ser Leu Tyr Asn Leu Leu Asn Leu Thr Ala Leu Asp Trp Ser Leu Leu 
705                 710                 715                 720 


Ser Lys Lys Glu Cys Leu Ser Tyr Gly Gly Arg Leu Leu Gly Asn Ser 
                725                 730                 735     


Cys Lys Phe Ile Pro Asp Leu Ala Leu Met Ser Phe Ile Leu Phe Phe 
            740                 745                 750         


Gly Thr Tyr Ser Met Thr Leu Thr Leu Lys Lys Phe Lys Phe Ser Arg 
        755                 760                 765             


Tyr Phe Pro Thr Lys Val Arg Ala Leu Val Ala Asp Phe Ser Ile Val 
    770                 775                 780                 


Phe Ser Ile Leu Met Phe Cys Gly Ile Asp Ala Cys Phe Gly Leu Glu 
785                 790                 795                 800 


Thr Pro Lys Leu His Val Pro Ser Val Ile Lys Pro Thr Arg Pro Asp 
                805                 810                 815     


Arg Gly Trp Phe Val Ala Pro Phe Gly Lys Asn Pro Trp Trp Val Tyr 
            820                 825                 830         


Pro Ala Ser Ile Leu Pro Ala Leu Leu Val Thr Ile Leu Ile Phe Met 
        835                 840                 845             


Asp Gln Gln Ile Thr Ala Val Ile Val Asn Arg Lys Glu Asn Lys Leu 
    850                 855                 860                 


Lys Lys Ala Ala Gly Tyr His Leu Asp Leu Phe Trp Val Gly Ile Leu 
865                 870                 875                 880 


Met Ala Leu Cys Ser Phe Met Gly Leu Pro Trp Tyr Val Ala Ala Thr 
                885                 890                 895     


Val Ile Ser Ile Ala His Ile Asp Ser Leu Lys Met Glu Thr Glu Thr 
            900                 905                 910         


Ser Ala Pro Gly Glu Gln Pro Gln Phe Leu Gly Val Arg Glu Gln Arg 
        915                 920                 925             


Val Thr Gly Ile Ile Val Phe Ile Leu Thr Gly Ile Ser Val Phe Leu 
    930                 935                 940                 


Ala Pro Ile Leu Lys Cys Ile Pro Leu Pro Val Leu Tyr Gly Val Phe 
945                 950                 955                 960 


Leu Tyr Met Gly Val Ala Ser Leu Asn Gly Ile Gln Met Gly Thr Gly 
                965                 970                 975     


Gly Ser Glu Phe Lys Ile Gln Lys Lys Leu Thr Pro Phe Trp Glu Arg 
            980                 985                 990         


Cys Lys Leu Phe Leu Met Pro Ala  Lys His Gln Pro Asp  His Ala Phe 
        995                 1000                 1005             


Leu Arg  His Val Pro Leu Arg  Arg Ile His Leu Phe  Thr Leu Val 
    1010                 1015                 1020             


Gln Ile  Leu Cys Leu Ala Val  Leu Trp Ile Leu Lys  Ser Thr Val 
    1025                 1030                 1035             


Ala Ala  Ile Ile Phe Pro Val  Met Ile Leu Gly Leu  Ile Ile Val 
    1040                 1045                 1050             


Arg Arg  Leu Leu Asp Phe Ile  Phe Ser Gln His Asp  Leu Ala Trp 
    1055                 1060                 1065             


Ile Asp  Asn Ile Leu Pro Glu  Lys Glu Lys Lys Glu  Thr Asp Lys 
    1070                 1075                 1080             


Lys Arg  Lys Arg Lys Lys Gly  Ala His Glu Asp Cys  Asp Glu Glu 
    1085                 1090                 1095             


Pro Gln  Phe Pro Pro Pro Ser  Val Ile Lys Ile Pro  Met Glu Ser 
    1100                 1105                 1110             


Val Gln  Ser Asp Pro Gln Asn  Gly Ile His Cys Ile  Ala Arg Lys 
    1115                 1120                 1125             


Arg Ser  Ser Ser Trp Ser Tyr  Ser Leu 
    1130                 1135         


<210>  4794
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  4794

Met Leu Leu Gln Ser Gln Thr Met Gly Val Ser His Ser Phe Thr Pro 
1               5                   10                  15      


Lys Gly Ile Thr Ile Pro Gln Arg Glu Lys Pro Gly His Met Tyr Gln 
            20                  25                  30          


Asn Glu Asp Tyr Leu Gln Asn Gly Leu Pro Thr Glu Thr Thr Val Leu 
        35                  40                  45              


Gly Thr Val Gln Ile Leu Cys Cys Leu Leu Ile Ser Ser Leu Gly Ala 
    50                  55                  60                  


Ile Leu Val Phe Ala Pro Tyr Pro Ser His Phe Asn Pro Ala Ile Ser 
65                  70                  75                  80  


Thr Thr Leu Met Ser Gly Tyr Pro Phe Leu Gly Ala Leu Cys Phe Gly 
                85                  90                  95      


Ile Thr Gly Ser Leu Ser Ile Ile Ser Gly Lys Gln Ser Thr Lys Pro 
            100                 105                 110         


Phe Asp Leu Ser Ser Leu Thr Ser Asn Ala Val Ser Ser Val Thr Ala 
        115                 120                 125             


Gly Ala Gly Leu Phe Leu Leu Ala Asp Ser Met Val Ala Leu Arg Thr 
    130                 135                 140                 


Ala Ser Gln His Cys Gly Ser Glu Met Asp Tyr Leu Ser Ser Leu Pro 
145                 150                 155                 160 


Tyr Ser Glu Tyr Tyr Tyr Pro Ile Tyr Glu Ile Lys Asp Cys Leu Leu 
                165                 170                 175     


Thr Ser Val Ser Leu Thr Gly Val Leu Val Val Met Leu Ile Phe Thr 
            180                 185                 190         


Val Leu Glu Leu Leu Leu Ala Ala Tyr Ser Ser Val Phe Trp Trp Lys 
        195                 200                 205             


Gln Leu Tyr Ser Asn Asn Pro Gly Ser Ser Phe Ser Ser Thr Gln Ser 
    210                 215                 220                 


Gln Asp His Ile Gln Gln Val Lys Lys Ser Ser Ser Arg Ser Trp Ile 
225                 230                 235                 240 


<210>  4795
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  4795

Met Ala Ser Ala Asp Ser Arg Arg Val Ala Asp Gly Gly Gly Ala Gly 
1               5                   10                  15      


Gly Thr Phe Gln Pro Tyr Leu Asp Thr Leu Arg Gln Glu Leu Gln Gln 
            20                  25                  30          


Thr Asp Pro Thr Leu Leu Ser Val Val Val Ala Val Leu Ala Val Leu 
        35                  40                  45              


Leu Thr Leu Val Phe Trp Lys Leu Ile Arg Ser Arg Arg Ser Ser Gln 
    50                  55                  60                  


Arg Ala Val Leu Leu Val Gly Leu Cys Asp Ser Gly Lys Thr Leu Leu 
65                  70                  75                  80  


Phe Val Arg Leu Leu Thr Gly Leu Tyr Arg Asp Thr Gln Thr Ser Ile 
                85                  90                  95      


Thr Asp Ser Cys Ala Val Tyr Arg Val Asn Asn Asn Arg Gly Asn Ser 
            100                 105                 110         


Leu Thr Leu Ile Asp Leu Pro Gly His Glu Ser Leu Arg Leu Gln Phe 
        115                 120                 125             


Leu Glu Arg Phe Lys Ser Ser Ala Arg Ala Ile Val Phe Val Val Asp 
    130                 135                 140                 


Ser Ala Ala Phe Gln Arg Glu Val Lys Asp Val Ala Glu Phe Leu Tyr 
145                 150                 155                 160 


Gln Val Leu Ile Asp Ser Met Gly Leu Lys Asn Thr Pro Ser Phe Leu 
                165                 170                 175     


Ile Ala Cys Asn Lys Gln Asp Ile Ala Met Ala Lys Ser Ala Lys Leu 
            180                 185                 190         


Ile Gln Gln Gln Leu Glu Lys Glu Leu Asn Thr Leu Arg Val Thr Arg 
        195                 200                 205             


Ser Ala Ala Pro Ser Thr Leu Asp Ser Ser Ser Thr Ala Pro Ala Gln 
    210                 215                 220                 


Leu Gly Lys Lys Gly Lys Glu Phe Glu Phe Ser Gln Leu Pro Leu Lys 
225                 230                 235                 240 


Val Glu Phe Leu Glu Cys Ser Ala Lys Gly Gly Arg Gly Asp Val Gly 
                245                 250                 255     


Ser Ala Asp Ile Gln Asp Leu Glu Lys Trp Leu Ala Lys Ile Ala 
            260                 265                 270     


<210>  4796
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  4796

Met Ala Arg Arg Ser Arg His Arg Leu Leu Leu Leu Leu Leu Arg Tyr 
1               5                   10                  15      


Leu Val Val Ala Leu Gly Tyr His Lys Ala Tyr Gly Phe Ser Ala Pro 
            20                  25                  30          


Lys Asp Gln Gln Val Val Thr Ala Val Glu Tyr Gln Glu Ala Ile Leu 
        35                  40                  45              


Ala Cys Lys Thr Pro Lys Lys Thr Val Ser Ser Arg Leu Glu Trp Lys 
    50                  55                  60                  


Lys Leu Gly Arg Ser Val Ser Phe Val Tyr Tyr Gln Gln Thr Leu Gln 
65                  70                  75                  80  


Gly Asp Phe Lys Asn Arg Ala Glu Met Ile Asp Phe Asn Ile Arg Ile 
                85                  90                  95      


Lys Asn Val Thr Arg Ser Asp Ala Gly Lys Tyr Arg Cys Glu Val Ser 
            100                 105                 110         


Ala Pro Ser Glu Gln Gly Gln Asn Leu Glu Glu Asp Thr Val Thr Leu 
        115                 120                 125             


Glu Val Leu Val Ala Pro Ala Val Pro Ser Cys Glu Val Pro Ser Ser 
    130                 135                 140                 


Ala Leu Ser Gly Thr Val Val Glu Leu Arg Cys Gln Asp Lys Glu Gly 
145                 150                 155                 160 


Asn Pro Ala Pro Glu Tyr Thr Trp Phe Lys Asp Gly Ile Arg Leu Leu 
                165                 170                 175     


Glu Asn Pro Arg Leu Gly Ser Gln Ser Thr Asn Ser Ser Tyr Thr Met 
            180                 185                 190         


Asn Thr Lys Thr Gly Thr Leu Gln Phe Asn Thr Val Ser Lys Leu Asp 
        195                 200                 205             


Thr Gly Glu Tyr Ser Cys Glu Ala Arg Asn Ser Val Gly Tyr Arg Arg 
    210                 215                 220                 


Cys Pro Gly Lys Arg Met Gln Val Asp Asp Leu Asn Ile Ser Gly Ile 
225                 230                 235                 240 


Ile Ala Ala Val Val Val Val Ala Leu Val Ile Ser Val Cys Gly Leu 
                245                 250                 255     


Gly Val Cys Tyr Ala Gln Arg Lys Gly Tyr Phe Ser Lys Glu Thr Ser 
            260                 265                 270         


Phe Gln Lys Ser Asn Ser Ser Ser Lys Ala Thr Thr Met Ser Glu Asn 
        275                 280                 285             


Asp Phe Lys His Thr Lys Ser Phe Ile Ile 
    290                 295             


<210>  4797
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  4797

Met Glu Thr Leu Tyr Arg Val Pro Phe Leu Val Leu Glu Cys Pro Asn 
1               5                   10                  15      


Leu Lys Leu Lys Lys Pro Pro Trp Leu His Met Pro Ser Ala Met Thr 
            20                  25                  30          


Val Tyr Ala Leu Val Val Val Ser Tyr Phe Leu Ile Thr Gly Gly Ile 
        35                  40                  45              


Ile Tyr Asp Val Ile Val Glu Pro Pro Ser Val Gly Ser Met Thr Asp 
    50                  55                  60                  


Glu His Gly His Gln Arg Pro Val Ala Phe Leu Ala Tyr Arg Val Asn 
65                  70                  75                  80  


Gly Gln Tyr Ile Met Glu Gly Leu Ala Ser Ser Phe Leu Phe Thr Met 
                85                  90                  95      


Gly Gly Leu Gly Phe Ile Ile Leu Asp Arg Ser Asn Ala Pro Asn Ile 
            100                 105                 110         


Pro Lys Leu Asn Arg Phe Leu Leu Leu Phe Ile Gly Phe Val Cys Val 
        115                 120                 125             


Leu Leu Ser Phe Phe Met Ala Arg Val Phe Met Arg Met Lys Leu Pro 
    130                 135                 140                 


Gly Tyr Leu Met Gly 
145                 


<210>  4798
<211>  628
<212>  PRT
<213>  Homo sapiens

<400>  4798

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile 
            260                 265                 270         


Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met 
        275                 280                 285             


Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys 
    290                 295                 300                 


Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp 
305                 310                 315                 320 


Gly Lys Thr Gly Ala Pro Asn Glu Cys Arg Thr Cys Lys Cys Asn Gly 
                325                 330                 335     


His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser Gly 
            340                 345                 350         


Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu Gly 
        355                 360                 365             


Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg 
    370                 375                 380                 


Pro Phe Ser Ala Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro Val 
385                 390                 395                 400 


Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser 
                405                 410                 415     


Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp 
            420                 425                 430         


Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro 
        435                 440                 445             


Cys Asp Cys Ala Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile Ser 
    450                 455                 460                 


Ser His Thr Asp Ile Asp Trp Tyr His Glu Val Pro Asp Phe Arg Pro 
465                 470                 475                 480 


Val His Asn Lys Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln Gly 
                485                 490                 495     


Phe Ser Ala Leu Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln Thr 
            500                 505                 510         


Leu Gly Asn Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu 
        515                 520                 525             


Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val 
    530                 535                 540                 


Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe 
545                 550                 555                 560 


Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys 
                565                 570                 575     


Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His 
            580                 585                 590         


Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val 
        595                 600                 605             


Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys 
    610                 615                 620                 


Arg Glu Cys Lys 
625             


<210>  4799
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  4799

Met Lys Gln Lys Met Met Ala Arg Leu Leu Arg Thr Ser Phe Ala Leu 
1               5                   10                  15      


Leu Phe Leu Gly Leu Phe Gly Val Leu Gly Ala Ala Thr Ile Ser Cys 
            20                  25                  30          


Arg Asn Glu Glu Gly Lys Ala Val Asp Trp Phe Thr Phe Tyr Lys Leu 
        35                  40                  45              


Pro Lys Arg Gln Asn Lys Glu Ser Gly Glu Thr Gly Leu Glu Tyr Leu 
    50                  55                  60                  


Tyr Leu Asp Ser Thr Thr Arg Ser Trp Arg Lys Ser Glu Gln Leu Met 
65                  70                  75                  80  


Asn Asp Thr Lys Ser Val Leu Gly Arg Thr Leu Gln Gln Leu Tyr Glu 
                85                  90                  95      


Ala Tyr Ala Ser Lys Ser Asn Asn Thr Ala Tyr Leu Ile Tyr Asn Asp 
            100                 105                 110         


Gly Val Pro Lys Pro Val Asn Tyr Ser Arg Lys Tyr Gly His Thr Lys 
        115                 120                 125             


Gly Leu Leu Leu Trp Asn Arg Val Gln Gly Phe Trp Leu Ile His Ser 
    130                 135                 140                 


Ile Pro Gln Phe Pro Pro Ile Pro Glu Glu Gly Tyr Asp Tyr Pro Pro 
145                 150                 155                 160 


Thr Gly Arg Arg Asn Gly Gln Ser Gly Ile Cys Ile Thr Phe Lys Tyr 
                165                 170                 175     


Asn Gln Tyr Glu Ala Ile Asp Ser Gln Leu Leu Val Cys Asn Pro Asn 
            180                 185                 190         


Val Tyr Ser Cys Ser Ile Pro Ala Thr Phe His Gln Glu Leu Ile His 
        195                 200                 205             


Met Pro Gln Leu Cys Thr Arg Ala Ser Ser Ser Glu Ile Pro Gly Arg 
    210                 215                 220                 


Leu Leu Thr Thr Leu Gln Ser Ala Gln Gly Gln Lys Phe Leu His Phe 
225                 230                 235                 240 


Ala Lys Ser Asp Ser Phe Leu Asp Asp Ile Phe Ala Ala Trp Met Ala 
                245                 250                 255     


Gln Arg Leu Lys Thr His Leu Leu Thr Glu Thr Trp Gln Arg Lys Arg 
            260                 265                 270         


Gln Glu Leu Pro Ser Asn Cys Ser Leu Pro Tyr His Val Tyr Asn Ile 
        275                 280                 285             


Lys Ala Ile Lys Leu Ser Arg His Ser Tyr Phe Ser Ser Tyr Gln Asp 
    290                 295                 300                 


His Ala Lys Trp Cys Ile Ser Gln Lys Gly Thr Lys Asn Arg Trp Thr 
305                 310                 315                 320 


Cys Ile Gly Asp Leu Asn Arg Ser Pro His Gln Ala Phe Arg Ser Gly 
                325                 330                 335     


Gly Phe Ile Cys Thr Gln Asn Trp Gln Ile Tyr Gln Ala Phe Gln Gly 
            340                 345                 350         


Leu Val Leu Tyr Tyr Glu Ser Cys Lys 
        355                 360     


<210>  4800
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  4800

Met Val Tyr Ile Ser Asn Gly Gln Val Leu Asp Ser Arg Ser Gln Ser 
1               5                   10                  15      


Pro Trp Arg Leu Ser Leu Ile Thr Asp Phe Phe Trp Gly Ile Ala Glu 
            20                  25                  30          


Phe Val Val Leu Phe Phe Lys Thr Leu Leu Gln Gln Asp Val Lys Lys 
        35                  40                  45              


Arg Arg Ser Tyr Gly Asn Ser Ser Asp Ser Arg Tyr Asp Asp Gly Arg 
    50                  55                  60                  


Gly Pro Pro Gly Asn Pro Pro Arg Arg Met Gly Arg Ile Asn His Leu 
65                  70                  75                  80  


Arg Gly Pro Ser Pro Pro Pro Met Ala Gly Gly Gly Arg 
                85                  90              


<210>  4801
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  4801

Met Ala Val Leu Phe Leu Leu Leu Phe Leu Cys Gly Thr Pro Gln Ala 
1               5                   10                  15      


Ala Asp Asn Met Gln Ala Ile Tyr Val Ala Leu Gly Glu Ala Val Glu 
            20                  25                  30          


Leu Pro Cys Pro Ser Pro Pro Thr Leu His Gly Asp Glu His Leu Ser 
        35                  40                  45              


Trp Phe Cys Ser Pro Ala Ala Gly Ser Phe Thr Thr Leu Val Ala Gln 
    50                  55                  60                  


Val Gln Val Gly Arg Pro Ala Pro Asp Pro Gly Lys Pro Gly Arg Glu 
65                  70                  75                  80  


Ser Arg Leu Arg Leu Leu Gly Asn Tyr Ser Leu Trp Leu Glu Gly Ser 
                85                  90                  95      


Lys Glu Glu Asp Ala Gly Arg Tyr Trp Cys Ala Val Leu Gly Gln His 
            100                 105                 110         


His Asn Tyr Gln Asn Trp Arg Val Tyr Asp Val Leu Val Leu Lys Gly 
        115                 120                 125             


Ser Gln Leu Ser Ala Arg Ala Ala Asp Gly Ser Pro Cys Asn Val Leu 
    130                 135                 140                 


Leu Cys Ser Val Val Pro Ser Arg Arg Met Asp Ser Val Thr Trp Gln 
145                 150                 155                 160 


Glu Gly Lys Gly Pro Val Arg Gly Arg Val Gln Ser Phe Trp Gly Ser 
                165                 170                 175     


Glu Ala Ala Leu Leu Leu Val Cys Pro Gly Glu Gly Leu Ser Glu Pro 
            180                 185                 190         


Arg Ser Arg Arg Pro Arg Ile Ile Arg Cys Leu Met Thr His Asn Lys 
        195                 200                 205             


Gly Val Ser Phe Ser Leu Ala Ala Ser Ile Asp Ala Ser Pro Ala Leu 
    210                 215                 220                 


Cys Ala Pro Ser Thr Gly Trp Asp Met Pro Trp Ile Leu Met Leu Leu 
225                 230                 235                 240 


Leu Thr Met Gly Gln Gly Val Val Ile Leu Ala Leu Ser Ile Val Leu 
                245                 250                 255     


Trp Arg Gln Arg Val Arg Gly Ala Pro Gly Arg Asp Ala Ser Ile Pro 
            260                 265                 270         


Gln Phe Lys Pro Glu Ile Gln Val Tyr Glu Asn Ile His Leu Ala Arg 
        275                 280                 285             


Leu Gly Pro Pro Ala His Lys Pro Arg 
    290                 295         


<210>  4802
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  4802

Met Lys Pro Gln Phe Val Gly Ile Leu Leu Ser Ser Leu Leu Gly Ala 
1               5                   10                  15      


Ala Leu Gly Asn Arg Met Arg Cys Tyr Asn Cys Gly Gly Ser Pro Ser 
            20                  25                  30          


Ser Ser Cys Lys Glu Ala Val Thr Thr Cys Gly Glu Gly Arg Pro Gln 
        35                  40                  45              


Pro Gly Leu Glu Gln Ile Lys Leu Pro Gly Asn Pro Pro Val Thr Leu 
    50                  55                  60                  


Ile His Gln His Pro Ala Cys Val Ala Ala His His Cys Asn Gln Val 
65                  70                  75                  80  


Glu Thr Glu Ser Val Gly Asp Val Thr Tyr Pro Ala His Arg Asp Cys 
                85                  90                  95      


Tyr Leu Gly Asp Leu Cys Asn Ser Ala Val Ala Ser His Val Ala Pro 
            100                 105                 110         


Ala Gly Ile Leu Ala Ala Ala Ala Thr Ala Leu Thr Cys Leu Leu Pro 
        115                 120                 125             


Gly Leu Trp Ser Gly 
    130             


<210>  4803
<211>  828
<212>  PRT
<213>  Homo sapiens

<400>  4803

Met Arg Pro Arg Pro Glu Gly Arg Gly Leu Arg Ala Gly Val Ala Leu 
1               5                   10                  15      


Ser Pro Ala Leu Leu Leu Leu Leu Leu Leu Pro Pro Pro Pro Thr Leu 
            20                  25                  30          


Leu Gly Arg Leu Trp Ala Ala Gly Thr Pro Ser Pro Ser Ala Pro Gly 
        35                  40                  45              


Ala Arg Gln Asp Gly Ala Leu Gly Ala Gly Arg Val Lys Arg Gly Trp 
    50                  55                  60                  


Val Trp Asn Gln Phe Phe Val Val Glu Glu Tyr Thr Gly Thr Glu Pro 
65                  70                  75                  80  


Leu Tyr Val Gly Lys Ile His Ser Asp Ser Asp Glu Gly Asp Gly Ala 
                85                  90                  95      


Ile Lys Tyr Thr Ile Ser Gly Glu Gly Ala Gly Thr Ile Phe Leu Ile 
            100                 105                 110         


Asp Glu Leu Thr Gly Asp Ile His Ala Met Glu Arg Leu Asp Arg Glu 
        115                 120                 125             


Gln Lys Thr Phe Tyr Thr Leu Arg Ala Gln Ala Arg Asp Arg Ala Thr 
    130                 135                 140                 


Asn Arg Leu Leu Glu Pro Glu Ser Glu Phe Ile Ile Lys Val Gln Asp 
145                 150                 155                 160 


Ile Asn Asp Ser Glu Pro Arg Phe Leu His Gly Pro Tyr Ile Gly Ser 
                165                 170                 175     


Val Ala Glu Leu Ser Pro Thr Gly Thr Ser Val Met Gln Val Met Ala 
            180                 185                 190         


Ser Asp Ala Asp Asp Pro Thr Tyr Gly Ser Ser Ala Arg Leu Val Tyr 
        195                 200                 205             


Ser Val Leu Asp Gly Glu His His Phe Thr Val Asp Pro Lys Thr Gly 
    210                 215                 220                 


Val Ile Arg Thr Ala Val Pro Asp Leu Asp Arg Glu Ser Gln Glu Arg 
225                 230                 235                 240 


Tyr Glu Val Val Ile Gln Ala Thr Asp Met Ala Gly Gln Leu Gly Gly 
                245                 250                 255     


Leu Ser Gly Ser Thr Thr Val Thr Ile Val Val Thr Asp Val Asn Asp 
            260                 265                 270         


Asn Pro Pro Arg Phe Pro Gln Lys Met Tyr Gln Phe Ser Ile Gln Glu 
        275                 280                 285             


Ser Ala Pro Ile Gly Thr Ala Val Gly Arg Val Lys Ala Glu Asp Ser 
    290                 295                 300                 


Asp Val Gly Glu Asn Thr Asp Met Thr Tyr His Leu Lys Asp Glu Ser 
305                 310                 315                 320 


Ser Ser Gly Gly Asp Val Phe Lys Val Thr Thr Asp Ser Asp Thr Gln 
                325                 330                 335     


Glu Ala Ile Ile Val Val Gln Lys Arg Leu Asp Phe Glu Ser Gln Pro 
            340                 345                 350         


Val His Thr Val Ile Leu Glu Ala Leu Asn Lys Phe Val Asp Pro Arg 
        355                 360                 365             


Phe Ala Asp Leu Gly Thr Phe Arg Asp Gln Ala Ile Val Arg Val Ala 
    370                 375                 380                 


Val Thr Asp Val Asp Glu Pro Pro Glu Phe Arg Pro Pro Ser Gly Leu 
385                 390                 395                 400 


Leu Glu Val Gln Glu Asp Ala Gln Val Gly Ser Leu Val Gly Val Val 
                405                 410                 415     


Thr Ala Arg Asp Pro Asp Ala Ala Asn Arg Pro Val Arg Tyr Ala Ile 
            420                 425                 430         


Asp Arg Glu Ser Asp Leu Asp Gln Ile Phe Asp Ile Asp Ala Asp Thr 
        435                 440                 445             


Gly Ala Ile Val Thr Gly Lys Gly Leu Asp Arg Glu Thr Ala Gly Trp 
    450                 455                 460                 


His Asn Ile Thr Val Leu Ala Met Glu Ala Asp Asn His Ala Gln Leu 
465                 470                 475                 480 


Ser Arg Ala Ser Leu Arg Ile Arg Ile Leu Asp Val Asn Asp Asn Pro 
                485                 490                 495     


Pro Glu Leu Ala Thr Pro Tyr Glu Ala Ala Val Cys Glu Asp Ala Lys 
            500                 505                 510         


Pro Gly Gln Leu Ile Gln Thr Ile Ser Val Val Asp Arg Asp Glu Pro 
        515                 520                 525             


Gln Gly Gly His Arg Phe Tyr Phe Arg Leu Val Pro Glu Ala Pro Ser 
    530                 535                 540                 


Asn Pro His Phe Ser Leu Leu Asp Ile Gln Asp Asn Thr Ala Ala Val 
545                 550                 555                 560 


His Thr Gln His Val Gly Phe Asn Arg Gln Glu Gln Asp Val Phe Phe 
                565                 570                 575     


Leu Pro Ile Leu Val Val Asp Ser Gly Pro Pro Thr Leu Ser Ser Thr 
            580                 585                 590         


Gly Thr Leu Thr Ile Arg Ile Cys Gly Cys Asp Ser Ser Gly Thr Ile 
        595                 600                 605             


Gln Ser Cys Asn Thr Thr Ala Phe Val Met Ala Ala Ser Leu Ser Pro 
    610                 615                 620                 


Gly Ala Leu Ile Ala Leu Leu Val Cys Val Leu Ile Leu Val Val Leu 
625                 630                 635                 640 


Val Leu Leu Ile Leu Thr Leu Arg Arg His His Lys Ser His Leu Ser 
                645                 650                 655     


Ser Asp Glu Asp Glu Asp Met Arg Asp Asn Val Ile Lys Tyr Asn Asp 
            660                 665                 670         


Glu Gly Gly Gly Glu Gln Asp Thr Glu Ala Tyr Asp Met Ser Ala Leu 
        675                 680                 685             


Arg Ser Leu Tyr Asp Phe Gly Glu Leu Lys Gly Gly Asp Gly Gly Gly 
    690                 695                 700                 


Ser Ala Gly Gly Gly Ala Gly Gly Gly Ser Gly Gly Gly Ala Gly Ser 
705                 710                 715                 720 


Pro Pro Gln Ala His Leu Pro Ser Glu Arg His Ser Leu Pro Gln Gly 
                725                 730                 735     


Pro Pro Ser Pro Glu Pro Asp Phe Ser Val Phe Arg Asp Phe Ile Ser 
            740                 745                 750         


Arg Lys Val Ala Leu Ala Asp Gly Asp Leu Ser Val Pro Pro Tyr Asp 
        755                 760                 765             


Ala Phe Gln Thr Tyr Ala Phe Glu Gly Ala Asp Ser Pro Ala Ala Ser 
    770                 775                 780                 


Leu Ser Ser Leu His Ser Gly Ser Ser Gly Ser Glu Gln Asp Phe Ala 
785                 790                 795                 800 


Tyr Leu Ser Ser Trp Gly Pro Arg Phe Arg Pro Leu Ala Ala Leu Tyr 
                805                 810                 815     


Ala Gly His Arg Gly Asp Asp Glu Ala Gln Ala Ser 
            820                 825             


<210>  4804
<211>  574
<212>  PRT
<213>  Homo sapiens

<400>  4804

Met Arg Thr Leu Leu Thr Ile Leu Thr Val Gly Ser Leu Ala Ala His 
1               5                   10                  15      


Ala Pro Glu Asp Pro Ser Asp Leu Leu Gln His Val Lys Phe Gln Ser 
            20                  25                  30          


Ser Asn Phe Glu Asn Ile Leu Thr Trp Asp Ser Gly Pro Glu Gly Thr 
        35                  40                  45              


Pro Asp Thr Val Tyr Ser Ile Glu Tyr Lys Thr Tyr Gly Glu Arg Asp 
    50                  55                  60                  


Trp Val Ala Lys Lys Gly Cys Gln Arg Ile Thr Arg Lys Ser Cys Asn 
65                  70                  75                  80  


Leu Thr Val Glu Thr Gly Asn Leu Thr Glu Leu Tyr Tyr Ala Arg Val 
                85                  90                  95      


Thr Ala Val Ser Ala Gly Gly Arg Ser Ala Thr Lys Met Thr Asp Arg 
            100                 105                 110         


Phe Ser Ser Leu Gln His Thr Thr Leu Lys Pro Pro Asp Val Thr Cys 
        115                 120                 125             


Ile Ser Lys Val Arg Ser Ile Gln Met Ile Val His Pro Thr Pro Thr 
    130                 135                 140                 


Pro Ile Arg Ala Gly Asp Gly His Arg Leu Thr Leu Glu Asp Ile Phe 
145                 150                 155                 160 


His Asp Leu Phe Tyr His Leu Glu Leu Gln Val Asn Arg Thr Tyr Gln 
                165                 170                 175     


Met His Leu Gly Gly Lys Gln Arg Glu Tyr Glu Phe Phe Gly Leu Thr 
            180                 185                 190         


Pro Asp Thr Glu Phe Leu Gly Thr Ile Met Ile Cys Val Pro Thr Trp 
        195                 200                 205             


Ala Lys Glu Ser Ala Pro Tyr Met Cys Arg Val Lys Thr Leu Pro Asp 
    210                 215                 220                 


Arg Thr Trp Thr Tyr Ser Phe Ser Gly Ala Phe Leu Phe Ser Met Gly 
225                 230                 235                 240 


Phe Leu Val Ala Val Leu Cys Tyr Leu Ser Tyr Arg Tyr Val Thr Lys 
                245                 250                 255     


Pro Pro Ala Pro Pro Asn Ser Leu Asn Val Gln Arg Val Leu Thr Phe 
            260                 265                 270         


Gln Pro Leu Arg Phe Ile Gln Glu His Val Leu Ile Pro Val Phe Asp 
        275                 280                 285             


Leu Ser Gly Pro Ser Ser Leu Ala Gln Pro Val Gln Tyr Ser Gln Ile 
    290                 295                 300                 


Arg Val Ser Gly Pro Arg Glu Pro Ala Gly Ala Pro Gln Arg His Ser 
305                 310                 315                 320 


Leu Ser Glu Ile Thr Tyr Leu Gly Gln Pro Asp Ile Ser Ile Leu Gln 
                325                 330                 335     


Pro Ser Asn Val Pro Pro Pro Gln Ile Leu Ser Pro Leu Ser Tyr Ala 
            340                 345                 350         


Pro Asn Ala Ala Pro Glu Val Gly Pro Pro Ser Tyr Ala Pro Gln Val 
        355                 360                 365             


Thr Pro Glu Ala Gln Phe Pro Phe Tyr Ala Pro Gln Ala Ile Ser Lys 
    370                 375                 380                 


Val Gln Pro Ser Ser Tyr Ala Pro Gln Ala Thr Pro Asp Ser Trp Pro 
385                 390                 395                 400 


Pro Ser Tyr Gly Val Cys Met Glu Gly Ser Gly Lys Asp Ser Pro Thr 
                405                 410                 415     


Gly Thr Leu Ser Ser Pro Lys His Leu Arg Pro Lys Gly Gln Leu Gln 
            420                 425                 430         


Lys Glu Pro Pro Ala Gly Ser Cys Met Leu Gly Gly Leu Ser Leu Gln 
        435                 440                 445             


Glu Val Thr Ser Leu Ala Met Glu Glu Ser Gln Glu Ala Lys Ser Leu 
    450                 455                 460                 


His Gln Pro Leu Gly Ile Cys Thr Asp Arg Thr Ser Asp Pro Asn Val 
465                 470                 475                 480 


Leu His Ser Gly Glu Glu Gly Thr Pro Gln Tyr Leu Lys Gly Gln Leu 
                485                 490                 495     


Pro Leu Leu Ser Ser Val Gln Ile Glu Gly His Pro Met Ser Leu Pro 
            500                 505                 510         


Leu Gln Pro Pro Ser Arg Pro Cys Ser Pro Ser Asp Gln Gly Pro Ser 
        515                 520                 525             


Pro Trp Gly Leu Leu Glu Ser Leu Val Cys Pro Lys Asp Glu Ala Lys 
    530                 535                 540                 


Ser Pro Ala Pro Glu Thr Ser Asp Leu Glu Gln Pro Thr Glu Leu Asp 
545                 550                 555                 560 


Ser Leu Phe Arg Gly Leu Ala Leu Thr Val Gln Trp Glu Ser 
                565                 570                 


<210>  4805
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  4805

Met Ala Ala Ala Gly Pro Ala Ala Gly Pro Thr Gly Pro Glu Pro Met 
1               5                   10                  15      


Pro Ser Tyr Ala Gln Leu Val Gln Arg Gly Trp Gly Ser Ala Leu Ala 
            20                  25                  30          


Ala Ala Arg Gly Cys Thr Asp Cys Gly Trp Gly Leu Ala Arg Arg Gly 
        35                  40                  45              


Leu Ala Glu His Ala His Leu Ala Pro Pro Glu Leu Leu Leu Leu Ala 
    50                  55                  60                  


Leu Gly Ala Leu Gly Trp Thr Ala Leu Arg Ser Ala Ala Thr Ala Arg 
65                  70                  75                  80  


Leu Phe Arg Pro Leu Ala Lys Arg Cys Cys Leu Gln Pro Arg Asp Ala 
                85                  90                  95      


Ala Lys Met Pro Glu Ser Ala Trp Lys Phe Leu Phe Tyr Leu Gly Ser 
            100                 105                 110         


Trp Ser Tyr Ser Ala Tyr Leu Leu Phe Gly Thr Asp Tyr Pro Phe Phe 
        115                 120                 125             


His Asp Pro Pro Ser Val Phe Tyr Asp Trp Thr Pro Gly Met Ala Val 
    130                 135                 140                 


Pro Arg Asp Ile Ala Ala Ala Tyr Leu Leu Gln Gly Ser Phe Tyr Gly 
145                 150                 155                 160 


His Ser Ile Tyr Ala Thr Leu Tyr Met Asp Thr Trp Arg Lys Asp Ser 
                165                 170                 175     


Val Val Met Leu Leu His His Val Val Thr Leu Ile Leu Ile Val Ser 
            180                 185                 190         


Ser Tyr Ala Phe Arg Tyr His Asn Val Gly Ile Leu Val Leu Phe Leu 
        195                 200                 205             


His Asp Ile Ser Asp Val Gln Leu Glu Phe Thr Lys Leu Asn Ile Tyr 
    210                 215                 220                 


Phe Lys Ser Arg Gly Gly Ser Tyr His Arg Leu His Ala Leu Ala Ala 
225                 230                 235                 240 


Asp Leu Gly Cys Leu Ser Phe Gly Phe Ser Trp Phe Trp Phe Arg Leu 
                245                 250                 255     


Tyr Trp Phe Pro Leu Lys Val Leu Tyr Ala Thr Ser His Cys Ser Leu 
            260                 265                 270         


Arg Thr Val Pro Asp Ile Pro Phe Tyr Phe Phe Phe Asn Ala Leu Leu 
        275                 280                 285             


Leu Leu Leu Thr Leu Met Asn Leu Tyr Trp Phe Leu Tyr Ile Val Ala 
    290                 295                 300                 


Phe Ala Ala Lys Val Leu Thr Gly Gln Val His Glu Leu Lys Asp Leu 
305                 310                 315                 320 


Arg Glu Tyr Asp Thr Ala Glu Ala Gln Ser Leu Lys Pro Ser Lys Ala 
                325                 330                 335     


Glu Lys Pro Leu Arg Asn Gly Leu Val Lys Asp Lys Arg Phe 
            340                 345                 350 


<210>  4806
<211>  901
<212>  PRT
<213>  Homo sapiens

<400>  4806

Met Ser Thr Met Arg Leu Leu Thr Leu Ala Leu Leu Phe Ser Cys Ser 
1               5                   10                  15      


Val Ala Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile Gly Ala Val 
            20                  25                  30          


Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala Val Asn Gln 
        35                  40                  45              


Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn Ala Thr Ser 
    50                  55                  60                  


Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser Val Cys Glu 
65                  70                  75                  80  


Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser His Pro Pro 
                85                  90                  95      


Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr Thr Ala Gly 
            100                 105                 110         


Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met Ser Ile Tyr 
        115                 120                 125             


Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val Pro Pro Tyr 
    130                 135                 140                 


Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val Tyr Ser Trp 
145                 150                 155                 160 


Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly Arg Ala Ala 
                165                 170                 175     


Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser Lys Ala Glu 
            180                 185                 190         


Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn Val Thr Ala Leu Leu 
        195                 200                 205             


Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile Ile Leu Ser Ala Ser 
    210                 215                 220                 


Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala Ala Met Leu Asn Met 
225                 230                 235                 240 


Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu Arg Glu Ile Ser Gly 
                245                 250                 255     


Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu Gly Leu Gln Leu Ile 
            260                 265                 270         


Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp Ala Val Gly Val Val 
        275                 280                 285             


Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu Asn Ile Thr Asp Pro 
    290                 295                 300                 


Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp Lys Thr Gly Pro Leu 
305                 310                 315                 320 


Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala Asp Gly Val Thr Gly 
                325                 330                 335     


Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys Phe Ala Asn Tyr Ser 
            340                 345                 350         


Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln Val Gly Ile Tyr Asn 
        355                 360                 365             


Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile Ile Trp Pro Gly Gly 
    370                 375                 380                 


Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met Ser Thr Arg Leu Lys Ile 
385                 390                 395                 400 


Val Thr Ile His Gln Glu Pro Phe Val Tyr Val Lys Pro Thr Leu Ser 
                405                 410                 415     


Asp Gly Thr Cys Lys Glu Glu Phe Thr Val Asn Gly Asp Pro Val Lys 
            420                 425                 430         


Lys Val Ile Cys Thr Gly Pro Asn Asp Thr Ser Pro Gly Ser Pro Arg 
        435                 440                 445             


His Thr Val Pro Gln Cys Cys Tyr Gly Phe Cys Ile Asp Leu Leu Ile 
    450                 455                 460                 


Lys Leu Ala Arg Thr Met Asn Phe Thr Tyr Glu Val His Leu Val Ala 
465                 470                 475                 480 


Asp Gly Lys Phe Gly Thr Gln Glu Arg Val Asn Asn Ser Asn Lys Lys 
                485                 490                 495     


Glu Trp Asn Gly Met Met Gly Glu Leu Leu Ser Gly Gln Ala Asp Met 
            500                 505                 510         


Ile Val Ala Pro Leu Thr Ile Asn Asn Glu Arg Ala Gln Tyr Ile Glu 
        515                 520                 525             


Phe Ser Lys Pro Phe Lys Tyr Gln Gly Leu Thr Ile Leu Val Lys Lys 
    530                 535                 540                 


Glu Ile Pro Arg Ser Thr Leu Asp Ser Phe Met Gln Pro Phe Gln Ser 
545                 550                 555                 560 


Thr Leu Trp Leu Leu Val Gly Leu Ser Val His Val Val Ala Val Met 
                565                 570                 575     


Leu Tyr Leu Leu Asp Arg Phe Ser Pro Phe Gly Arg Phe Lys Val Asn 
            580                 585                 590         


Ser Glu Glu Glu Glu Glu Asp Ala Leu Thr Leu Ser Ser Ala Met Trp 
        595                 600                 605             


Phe Ser Trp Gly Val Leu Leu Asn Ser Gly Ile Gly Glu Gly Ala Pro 
    610                 615                 620                 


Arg Ser Phe Ser Ala Arg Ile Leu Gly Met Val Trp Ala Gly Phe Ala 
625                 630                 635                 640 


Met Ile Ile Val Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu Val 
                645                 650                 655     


Leu Asp Arg Pro Glu Glu Arg Ile Thr Gly Ile Asn Asp Pro Arg Leu 
            660                 665                 670         


Arg Asn Pro Ser Asp Lys Phe Ile Tyr Ala Thr Val Lys Gln Ser Ser 
        675                 680                 685             


Val Asp Ile Tyr Phe Arg Arg Gln Val Glu Leu Ser Thr Met Tyr Arg 
    690                 695                 700                 


His Met Glu Lys His Asn Tyr Glu Ser Ala Ala Glu Ala Ile Gln Ala 
705                 710                 715                 720 


Val Arg Asp Asn Lys Leu His Ala Phe Ile Trp Asp Ser Ala Val Leu 
                725                 730                 735     


Glu Phe Glu Ala Ser Gln Lys Cys Asp Leu Val Thr Thr Gly Glu Leu 
            740                 745                 750         


Phe Phe Arg Ser Gly Phe Gly Ile Gly Met Arg Lys Asp Ser Pro Trp 
        755                 760                 765             


Lys Gln Asn Val Ser Leu Ser Ile Leu Lys Ser His Glu Asn Gly Phe 
    770                 775                 780                 


Met Glu Asp Leu Asp Lys Thr Trp Val Arg Tyr Gln Glu Cys Asp Ser 
785                 790                 795                 800 


Arg Ser Asn Ala Pro Ala Thr Leu Thr Phe Glu Asn Met Ala Gly Val 
                805                 810                 815     


Phe Met Leu Val Ala Gly Gly Ile Val Ala Gly Ile Phe Leu Ile Phe 
            820                 825                 830         


Ile Glu Ile Ala Tyr Lys Arg His Lys Asp Ala Arg Arg Lys Gln Met 
        835                 840                 845             


Gln Leu Ala Phe Ala Ala Val Asn Val Trp Arg Lys Asn Leu Gln Ser 
    850                 855                 860                 


Thr Gly Gly Gly Arg Gly Ala Leu Gln Asn Gln Lys Asp Thr Val Leu 
865                 870                 875                 880 


Pro Arg Arg Ala Ile Glu Arg Glu Glu Gly Gln Leu Gln Leu Cys Ser 
                885                 890                 895     


Arg His Arg Glu Ser 
            900     


<210>  4807
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  4807

Met Thr Ser Lys Phe Leu Leu Val Ser Phe Ile Leu Ala Ala Leu Ser 
1               5                   10                  15      


Leu Ser Thr Thr Phe Ser Leu Gln Pro Asp Gln Gln Lys Val Leu Leu 
            20                  25                  30          


Val Ser Phe Asp Gly Phe Arg Trp Asp Tyr Leu Tyr Lys Val Pro Thr 
        35                  40                  45              


Pro His Phe His Tyr Ile Met Lys Tyr Gly Val His Val Lys Gln Val 
    50                  55                  60                  


Thr Asn Val Phe Ile Thr Lys Thr Tyr Pro Asn His Tyr Thr Leu Val 
65                  70                  75                  80  


Thr Gly Leu Phe Ala Glu Asn His Gly Ile Val Ala Asn Asp Met Phe 
                85                  90                  95      


Asp Pro Ile Arg Asn Lys Ser Phe Ser Leu Asp His Met Asn Ile Tyr 
            100                 105                 110         


Asp Ser Lys Phe Trp Glu Glu Ala Thr Pro Ile Trp Ile Thr Asn Gln 
        115                 120                 125             


Arg Ala Gly His Thr Ser Gly Ala Ala Met Trp Pro Gly Thr Asp Val 
    130                 135                 140                 


Lys Ile His Lys Arg Phe Pro Thr His Tyr Met Pro Tyr Asn Glu Ser 
145                 150                 155                 160 


Val Ser Phe Glu Asp Arg Val Ala Lys Ile Ile Glu Trp Phe Thr Ser 
                165                 170                 175     


Lys Glu Pro Ile Asn Leu Gly Leu Leu Tyr Trp Glu Asp Pro Asp Asp 
            180                 185                 190         


Met Gly His His Leu Gly Pro Asp Ser Pro Leu Met Gly Pro Val Ile 
        195                 200                 205             


Ser Asp Ile Asp Lys Lys Leu Gly Tyr Leu Ile Gln Met Leu Lys Lys 
    210                 215                 220                 


Ala Lys Leu Trp Asn Thr Leu Asn Leu Ile Ile Thr Ser Asp His Gly 
225                 230                 235                 240 


Met Thr Gln Cys Ser Glu Glu Arg Leu Ile Glu Leu Asp Gln Tyr Leu 
                245                 250                 255     


Asp Lys Asp His Tyr Thr Leu Ile Asp Gln Ser Pro Val Ala Ala Ile 
            260                 265                 270         


Leu Pro Lys Glu Gly Lys Phe Asp Glu Val Tyr Glu Ala Leu Thr His 
        275                 280                 285             


Ala His Pro Asn Leu Thr Val Tyr Lys Lys Glu Asp Val Pro Glu Arg 
    290                 295                 300                 


Trp His Tyr Lys Tyr Asn Ser Arg Ile Gln Pro Ile Ile Ala Val Ala 
305                 310                 315                 320 


Asp Glu Gly Trp His Ile Leu Gln Asn Lys Ser Asp Asp Phe Leu Leu 
                325                 330                 335     


Gly Asn His Gly Tyr Asp Asn Ala Leu Ala Asp Met His Pro Ile Phe 
            340                 345                 350         


Leu Ala His Gly Pro Ala Phe Arg Lys Asn Phe Ser Lys Glu Ala Met 
        355                 360                 365             


Asn Ser Thr Asp Leu Tyr Pro Leu Leu Cys His Leu Leu Asn Ile Thr 
    370                 375                 380                 


Ala Met Pro His Asn Gly Ser Phe Trp Asn Val Gln Asp Leu Leu Asn 
385                 390                 395                 400 


Ser Ala Met Pro Arg Val Val Pro Tyr Thr Gln Ser Thr Ile Leu Leu 
                405                 410                 415     


Pro Gly Ser Val Lys Pro Ala Glu Tyr Asp Gln Glu Gly Ser Tyr Pro 
            420                 425                 430         


Tyr Phe Ile Gly Val Ser Leu Gly Ser Ile Ile Val Ile Val Phe Phe 
        435                 440                 445             


Val Ile Phe Ile Lys His Leu Ile His Ser Gln Ile Pro Ala Leu Gln 
    450                 455                 460                 


Asp Met His Ala Glu Ile Ala Gln Pro Leu Leu Gln Ala 
465                 470                 475         


<210>  4808
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  4808

Met Ala Arg Leu Ala Leu Ser Pro Val Pro Ser His Trp Met Val Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ser Ala Glu Pro Val Pro Ala Ala Arg Ser Glu 
            20                  25                  30          


Asp Arg Tyr Arg Asn Pro Lys Gly Phe Ser Thr Leu Ala Gln Leu Lys 
        35                  40                  45              


Gln Arg Asn Thr Leu Lys Asp Gly Ile Ile Met Ile Gln Thr Leu Leu 
    50                  55                  60                  


Ile Ile Leu Phe Ile Ile Val Pro Ile Phe Leu Leu Leu Asp Lys Asp 
65                  70                  75                  80  


Asp Ser Lys Ala Gly Met Glu Glu Asp His Thr Tyr Glu Gly Leu Asp 
                85                  90                  95      


Ile Asp Gln Thr Ala Thr Tyr Glu Asp Ile Val Thr Leu Arg Thr Gly 
            100                 105                 110         


Glu Val Lys Trp Ser Val Gly Glu His Pro Gly Gln Glu 
        115                 120                 125 


<210>  4809
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  4809

Met Ser Ser Cys Arg Tyr Asn Gly Gly Val Met Arg Pro Leu Ser Asn 
1               5                   10                  15      


Leu Ser Ala Ser Arg Arg Asn Leu His Glu Met Asp Ser Glu Ala Gln 
            20                  25                  30          


Pro Leu Gln Pro Pro Ala Ser Val Gly Gly Gly Gly Gly Ala Ser Ser 
        35                  40                  45              


Pro Ser Ala Ala Ala Ala Ala Ala Ala Ala Val Ser Ser Ser Ala Pro 
    50                  55                  60                  


Glu Ile Val Val Ser Lys Pro Glu His Asn Asn Ser Asn Asn Leu Ala 
65                  70                  75                  80  


Leu Tyr Gly Thr Gly Gly Gly Gly Ser Thr Gly Gly Gly Gly Gly Gly 
                85                  90                  95      


Gly Gly Ser Gly His Gly Ser Ser Ser Gly Thr Lys Ser Ser Lys Lys 
            100                 105                 110         


Lys Asn Gln Asn Ile Gly Tyr Lys Leu Gly His Arg Arg Ala Leu Phe 
        115                 120                 125             


Glu Lys Arg Lys Arg Leu Ser Asp Tyr Ala Leu Ile Phe Gly Met Phe 
    130                 135                 140                 


Gly Ile Val Val Met Val Ile Glu Thr Glu Leu Ser Trp Gly Ala Tyr 
145                 150                 155                 160 


Asp Lys Ala Ser Leu Tyr Ser Leu Ala Leu Lys Cys Leu Ile Ser Leu 
                165                 170                 175     


Ser Thr Ile Ile Leu Leu Gly Leu Ile Ile Val Tyr His Ala Arg Glu 
            180                 185                 190         


Ile Gln Leu Phe Met Val Asp Asn Gly Ala Asp Asp Trp Arg Ile Ala 
        195                 200                 205             


Met Thr Tyr Glu Arg Ile Phe Phe Ile Cys Leu Glu Ile Leu Val Cys 
    210                 215                 220                 


Ala Ile His Pro Ile Pro Gly Asn Tyr Thr Phe Thr Trp Thr Ala Arg 
225                 230                 235                 240 


Leu Ala Phe Ser Tyr Ala Pro Ser Thr Thr Thr Ala Asp Val Asp Ile 
                245                 250                 255     


Ile Leu Ser Ile Pro Met Phe Leu Arg Leu Tyr Leu Ile Ala Arg Val 
            260                 265                 270         


Met Leu Leu His Ser Lys Leu Phe Thr Asp Ala Ser Ser Arg Ser Ile 
        275                 280                 285             


Gly Ala Leu Asn Lys Ile Asn Phe Asn Thr Arg Phe Val Met Lys Thr 
    290                 295                 300                 


Leu Met Thr Ile Cys Pro Gly Thr Val Leu Leu Val Phe Ser Ile Ser 
305                 310                 315                 320 


Leu Trp Ile Ile Ala Ala Trp Thr Val Arg Ala Cys Glu Arg Tyr His 
                325                 330                 335     


Asp Gln Gln Asp Val Thr Ser Asn Phe Leu Gly Ala Met Trp Leu Ile 
            340                 345                 350         


Ser Ile Thr Phe Leu Ser Ile Gly Tyr Gly Asp Met Val Pro Asn Thr 
        355                 360                 365             


Tyr Cys Gly Lys Gly Val Cys Leu Leu Thr Gly Ile Met Gly Ala Gly 
    370                 375                 380                 


Cys Thr Ala Leu Val Val Ala Val Val Ala Arg Lys Leu Glu Leu Thr 
385                 390                 395                 400 


Lys Ala Glu Lys His Val His Asn Phe Met Met Asp Thr Gln Leu Thr 
                405                 410                 415     


Lys Arg Val Lys Asn Ala Ala Ala Asn Val Leu Arg Glu Thr Trp Leu 
            420                 425                 430         


Ile Tyr Lys Asn Thr Lys Leu Val Lys Lys Ile Asp His Ala Lys Val 
        435                 440                 445             


Arg Lys His Gln Arg Lys Phe Leu Gln Ala Ile His Gln Leu Arg Ser 
    450                 455                 460                 


Val Lys Met Glu Gln Arg Lys Leu Asn Asp Gln Ala Asn Thr Leu Val 
465                 470                 475                 480 


Asp Leu Ala Lys Thr Gln Asn Ile Met Tyr Asp Met Ile Ser Asp Leu 
                485                 490                 495     


Asn Glu Arg Ser Glu Asp Phe Glu Lys Arg Ile Val Thr Leu Glu Thr 
            500                 505                 510         


Lys Leu Glu Thr Leu Ile Gly Ser Ile His Ala Leu Pro Gly Leu Ile 
        515                 520                 525             


Ser Gln Thr Ile Arg Gln Gln Gln Arg Asp Phe Ile Glu Ala Gln Met 
    530                 535                 540                 


Glu Ser Tyr Asp Lys His Val Thr Tyr Asn Ala Glu Arg Ser Arg Ser 
545                 550                 555                 560 


Ser Ser Arg Arg Arg Arg Ser Ser Ser Thr Ala Pro Pro Thr Ser Ser 
                565                 570                 575     


Glu Ser Ser 
            


<210>  4810
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  4810

Met Pro Asp Thr Asn Ser Thr Ile Asn Leu Ser Leu Ser Thr Arg Val 
1               5                   10                  15      


Thr Leu Ala Phe Phe Met Ser Leu Val Ala Phe Ala Ile Met Leu Gly 
            20                  25                  30          


Asn Ala Leu Val Ile Leu Ala Phe Val Val Asp Lys Asn Leu Arg His 
        35                  40                  45              


Arg Ser Ser Tyr Phe Phe Leu Asn Leu Ala Ile Ser Asp Phe Phe Val 
    50                  55                  60                  


Gly Val Ile Ser Ile Pro Leu Tyr Ile Pro His Thr Leu Phe Glu Trp 
65                  70                  75                  80  


Asp Phe Gly Lys Glu Ile Cys Val Phe Trp Leu Thr Thr Asp Tyr Leu 
                85                  90                  95      


Leu Cys Thr Ala Ser Val Tyr Asn Ile Val Leu Ile Ser Tyr Asp Arg 
            100                 105                 110         


Tyr Leu Ser Val Ser Asn Ala Val Ser Tyr Arg Thr Gln His Thr Gly 
        115                 120                 125             


Val Leu Lys Ile Val Thr Leu Met Val Ala Val Trp Val Leu Ala Phe 
    130                 135                 140                 


Leu Val Asn Gly Pro Met Ile Leu Val Ser Glu Ser Trp Lys Asp Glu 
145                 150                 155                 160 


Gly Ser Glu Cys Glu Pro Gly Phe Phe Ser Glu Trp Tyr Ile Leu Ala 
                165                 170                 175     


Ile Thr Ser Phe Leu Glu Phe Val Ile Pro Val Ile Leu Val Ala Tyr 
            180                 185                 190         


Phe Asn Met Asn Ile Tyr Trp Ser Leu Trp Lys Arg Asp His Leu Ser 
        195                 200                 205             


Arg Cys Gln Ser His Pro Gly Leu Thr Ala Val Ser Ser Asn Ile Cys 
    210                 215                 220                 


Gly His Ser Phe Arg Gly Arg Leu Ser Ser Arg Arg Ser Leu Ser Ala 
225                 230                 235                 240 


Ser Thr Glu Val Pro Ala Ser Phe His Ser Glu Arg Gln Arg Arg Lys 
                245                 250                 255     


Ser Ser Leu Met Phe Ser Ser Arg Thr Lys Met Asn Ser Asn Thr Ile 
            260                 265                 270         


Ala Ser Lys Met Gly Ser Phe Ser Gln Ser Asp Ser Val Ala Leu His 
        275                 280                 285             


Gln Arg Glu His Val Glu Leu Leu Arg Ala Arg Arg Leu Ala Lys Ser 
    290                 295                 300                 


Leu Ala Ile Leu Leu Gly Val Phe Ala Val Cys Trp Ala Pro Tyr Ser 
305                 310                 315                 320 


Leu Phe Thr Ile Val Leu Ser Phe Tyr Ser Ser Ala Thr Gly Pro Lys 
                325                 330                 335     


Ser Val Trp Tyr Arg Ile Ala Phe Trp Leu Gln Trp Phe Asn Ser Phe 
            340                 345                 350         


Val Asn Pro Leu Leu Tyr Pro Leu Cys His Lys Arg Phe Gln Lys Ala 
        355                 360                 365             


Phe Leu Lys Ile Phe Cys Ile Lys Lys Gln Pro Leu Pro Ser Gln His 
    370                 375                 380                 


Ser Arg Ser Val Ser Ser 
385                 390 


<210>  4811
<211>  871
<212>  PRT
<213>  Homo sapiens

<400>  4811

Met Ala Asp Ser Ser Glu Gly Pro Arg Ala Gly Pro Gly Glu Val Ala 
1               5                   10                  15      


Glu Leu Pro Gly Asp Glu Ser Gly Thr Pro Gly Gly Glu Ala Phe Pro 
            20                  25                  30          


Leu Ser Ser Leu Ala Asn Leu Phe Glu Gly Glu Asp Gly Ser Leu Ser 
        35                  40                  45              


Pro Ser Pro Ala Asp Ala Ser Arg Pro Ala Gly Pro Gly Asp Gly Arg 
    50                  55                  60                  


Pro Asn Leu Arg Met Lys Phe Gln Gly Ala Phe Arg Lys Gly Val Pro 
65                  70                  75                  80  


Asn Pro Ile Asp Leu Leu Glu Ser Thr Leu Tyr Glu Ser Ser Val Val 
                85                  90                  95      


Pro Gly Pro Lys Lys Ala Pro Met Asp Ser Leu Phe Asp Tyr Gly Thr 
            100                 105                 110         


Tyr Arg His His Ser Ser Asp Asn Lys Arg Trp Arg Lys Lys Ile Ile 
        115                 120                 125             


Glu Lys Gln Pro Gln Ser Pro Lys Ala Pro Ala Pro Gln Pro Pro Pro 
    130                 135                 140                 


Ile Leu Lys Val Phe Asn Arg Pro Ile Leu Phe Asp Ile Val Ser Arg 
145                 150                 155                 160 


Gly Ser Thr Ala Asp Leu Asp Gly Leu Leu Pro Phe Leu Leu Thr His 
                165                 170                 175     


Lys Lys Arg Leu Thr Asp Glu Glu Phe Arg Glu Pro Ser Thr Gly Lys 
            180                 185                 190         


Thr Cys Leu Pro Lys Ala Leu Leu Asn Leu Ser Asn Gly Arg Asn Asp 
        195                 200                 205             


Thr Ile Pro Val Leu Leu Asp Ile Ala Glu Arg Thr Gly Asn Met Arg 
    210                 215                 220                 


Glu Phe Ile Asn Ser Pro Phe Arg Asp Ile Tyr Tyr Arg Gly Gln Thr 
225                 230                 235                 240 


Ala Leu His Ile Ala Ile Glu Arg Arg Cys Lys His Tyr Val Glu Leu 
                245                 250                 255     


Leu Val Ala Gln Gly Ala Asp Val His Ala Gln Ala Arg Gly Arg Phe 
            260                 265                 270         


Phe Gln Pro Lys Asp Glu Gly Gly Tyr Phe Tyr Phe Gly Glu Leu Pro 
        275                 280                 285             


Leu Ser Leu Ala Ala Cys Thr Asn Gln Pro His Ile Val Asn Tyr Leu 
    290                 295                 300                 


Thr Glu Asn Pro His Lys Lys Ala Asp Met Arg Arg Gln Asp Ser Arg 
305                 310                 315                 320 


Gly Asn Thr Val Leu His Ala Leu Val Ala Ile Ala Asp Asn Thr Arg 
                325                 330                 335     


Glu Asn Thr Lys Phe Val Thr Lys Met Tyr Asp Leu Leu Leu Leu Lys 
            340                 345                 350         


Cys Ala Arg Leu Phe Pro Asp Ser Asn Leu Glu Ala Val Leu Asn Asn 
        355                 360                 365             


Asp Gly Leu Ser Pro Leu Met Met Ala Ala Lys Thr Gly Lys Ile Gly 
    370                 375                 380                 


Ile Phe Gln His Ile Ile Arg Arg Glu Val Thr Asp Glu Asp Thr Arg 
385                 390                 395                 400 


His Leu Ser Arg Lys Phe Lys Asp Trp Ala Tyr Gly Pro Val Tyr Ser 
                405                 410                 415     


Ser Leu Tyr Asp Leu Ser Ser Leu Asp Thr Cys Gly Glu Glu Ala Ser 
            420                 425                 430         


Val Leu Glu Ile Leu Val Tyr Asn Ser Lys Ile Glu Asn Arg His Glu 
        435                 440                 445             


Met Leu Ala Val Glu Pro Ile Asn Glu Leu Leu Arg Asp Lys Trp Arg 
    450                 455                 460                 


Lys Phe Gly Ala Val Ser Phe Tyr Ile Asn Val Val Ser Tyr Leu Cys 
465                 470                 475                 480 


Ala Met Val Ile Phe Thr Leu Thr Ala Tyr Tyr Gln Pro Leu Glu Gly 
                485                 490                 495     


Thr Pro Pro Tyr Pro Tyr Arg Thr Thr Val Asp Tyr Leu Arg Leu Ala 
            500                 505                 510         


Gly Glu Val Ile Thr Leu Phe Thr Gly Val Leu Phe Phe Phe Thr Asn 
        515                 520                 525             


Ile Lys Asp Leu Phe Met Lys Lys Cys Pro Gly Val Asn Ser Leu Phe 
    530                 535                 540                 


Ile Asp Gly Ser Phe Gln Leu Leu Tyr Phe Ile Tyr Ser Val Leu Val 
545                 550                 555                 560 


Ile Val Ser Ala Ala Leu Tyr Leu Ala Gly Ile Glu Ala Tyr Leu Ala 
                565                 570                 575     


Val Met Val Phe Ala Leu Val Leu Gly Trp Met Asn Ala Leu Tyr Phe 
            580                 585                 590         


Thr Arg Gly Leu Lys Leu Thr Gly Thr Tyr Ser Ile Met Ile Gln Lys 
        595                 600                 605             


Ile Leu Phe Lys Asp Leu Phe Arg Phe Leu Leu Val Tyr Leu Leu Phe 
    610                 615                 620                 


Met Ile Gly Tyr Ala Ser Ala Leu Val Ser Leu Leu Asn Pro Cys Ala 
625                 630                 635                 640 


Asn Met Lys Val Cys Asn Glu Asp Gln Thr Asn Cys Thr Val Pro Thr 
                645                 650                 655     


Tyr Pro Ser Cys Arg Asp Ser Glu Thr Phe Ser Thr Phe Leu Leu Asp 
            660                 665                 670         


Leu Phe Lys Leu Thr Ile Gly Met Gly Asp Leu Glu Met Leu Ser Ser 
        675                 680                 685             


Thr Lys Tyr Pro Val Val Phe Ile Ile Leu Leu Val Thr Tyr Ile Ile 
    690                 695                 700                 


Leu Thr Phe Val Leu Leu Leu Asn Met Leu Ile Ala Leu Met Gly Glu 
705                 710                 715                 720 


Thr Val Gly Gln Val Ser Lys Glu Ser Lys His Ile Trp Lys Leu Gln 
                725                 730                 735     


Trp Ala Thr Thr Ile Leu Asp Ile Glu Arg Ser Phe Pro Val Phe Leu 
            740                 745                 750         


Arg Lys Ala Phe Arg Ser Gly Glu Met Val Thr Val Gly Lys Ser Ser 
        755                 760                 765             


Asp Gly Thr Pro Asp Arg Arg Trp Cys Phe Arg Val Asp Glu Val Asn 
    770                 775                 780                 


Trp Ser His Trp Asn Gln Asn Leu Gly Ile Ile Asn Glu Asp Pro Gly 
785                 790                 795                 800 


Lys Asn Glu Thr Tyr Gln Tyr Tyr Gly Phe Ser His Thr Val Gly Arg 
                805                 810                 815     


Leu Arg Arg Asp Arg Trp Ser Ser Val Val Pro Arg Val Val Glu Leu 
            820                 825                 830         


Asn Lys Asn Ser Asn Pro Asp Glu Val Val Val Pro Leu Asp Ser Met 
        835                 840                 845             


Gly Asn Pro Arg Cys Asp Gly His Gln Gln Gly Tyr Pro Arg Lys Trp 
    850                 855                 860                 


Arg Thr Asp Asp Ala Pro Leu 
865                 870     


<210>  4812
<211>  757
<212>  PRT
<213>  Homo sapiens

<400>  4812

Met Thr Ser Gly Ser Val Phe Phe Tyr Ile Leu Ile Phe Gly Lys Tyr 
1               5                   10                  15      


Phe Ser His Gly Gly Gly Gln Asp Val Lys Cys Ser Leu Gly Tyr Phe 
            20                  25                  30          


Pro Cys Gly Asn Ile Thr Lys Cys Leu Pro Gln Leu Leu His Cys Asn 
        35                  40                  45              


Gly Val Asp Asp Cys Gly Asn Gln Ala Asp Glu Asp Asn Cys Gly Asp 
    50                  55                  60                  


Asn Asn Gly Trp Ser Leu Gln Phe Asp Lys Tyr Phe Ala Ser Tyr Tyr 
65                  70                  75                  80  


Lys Met Thr Ser Gln Tyr Pro Phe Glu Ala Glu Thr Pro Glu Cys Leu 
                85                  90                  95      


Val Gly Ser Val Pro Val Gln Cys Leu Cys Gln Gly Leu Glu Leu Asp 
            100                 105                 110         


Cys Asp Glu Thr Asn Leu Arg Ala Val Pro Ser Val Ser Ser Asn Val 
        115                 120                 125             


Thr Ala Met Ser Leu Gln Trp Asn Leu Ile Arg Lys Leu Pro Pro Asp 
    130                 135                 140                 


Cys Phe Lys Asn Tyr His Asp Leu Gln Lys Leu Tyr Leu Gln Asn Asn 
145                 150                 155                 160 


Lys Ile Thr Ser Ile Ser Ile Tyr Ala Phe Arg Gly Leu Asn Ser Leu 
                165                 170                 175     


Thr Lys Leu Tyr Leu Ser His Asn Arg Ile Thr Phe Leu Lys Pro Gly 
            180                 185                 190         


Val Phe Glu Asp Leu His Arg Leu Glu Trp Leu Ile Ile Glu Asp Asn 
        195                 200                 205             


His Leu Ser Arg Ile Ser Pro Pro Thr Phe Tyr Gly Leu Asn Ser Leu 
    210                 215                 220                 


Ile Leu Leu Val Leu Met Asn Asn Val Leu Thr Arg Leu Pro Asp Lys 
225                 230                 235                 240 


Pro Leu Cys Gln His Met Pro Arg Leu His Trp Leu Asp Leu Glu Gly 
                245                 250                 255     


Asn His Ile His Asn Leu Arg Asn Leu Thr Phe Ile Ser Cys Ser Asn 
            260                 265                 270         


Leu Thr Val Leu Val Met Arg Lys Asn Lys Ile Asn His Leu Asn Glu 
        275                 280                 285             


Asn Thr Phe Ala Pro Leu Gln Lys Leu Asp Glu Leu Asp Leu Gly Ser 
    290                 295                 300                 


Asn Lys Ile Glu Asn Leu Pro Pro Leu Ile Phe Lys Asp Leu Lys Glu 
305                 310                 315                 320 


Leu Ser Gln Leu Asn Leu Ser Tyr Asn Pro Ile Gln Lys Ile Gln Ala 
                325                 330                 335     


Asn Gln Phe Asp Tyr Leu Val Lys Leu Lys Ser Leu Ser Leu Glu Gly 
            340                 345                 350         


Ile Glu Ile Ser Asn Ile Gln Gln Arg Met Phe Arg Pro Leu Met Asn 
        355                 360                 365             


Leu Ser His Ile Tyr Phe Lys Lys Phe Gln Tyr Cys Gly Tyr Ala Pro 
    370                 375                 380                 


His Val Arg Ser Cys Lys Pro Asn Thr Asp Gly Ile Ser Ser Leu Glu 
385                 390                 395                 400 


Asn Leu Leu Ala Ser Ile Ile Gln Arg Val Phe Val Trp Val Val Ser 
                405                 410                 415     


Ala Val Thr Cys Phe Gly Asn Ile Phe Val Ile Cys Met Arg Pro Tyr 
            420                 425                 430         


Ile Arg Ser Glu Asn Lys Leu Tyr Ala Met Ser Ile Ile Ser Leu Cys 
        435                 440                 445             


Cys Ala Asp Cys Leu Met Gly Ile Tyr Leu Phe Val Ile Gly Gly Phe 
    450                 455                 460                 


Asp Leu Lys Phe Arg Gly Glu Tyr Asn Lys His Ala Gln Leu Trp Met 
465                 470                 475                 480 


Glu Ser Thr His Cys Gln Leu Val Gly Ser Leu Ala Ile Leu Ser Thr 
                485                 490                 495     


Glu Val Ser Val Leu Leu Leu Thr Phe Leu Thr Leu Glu Lys Tyr Ile 
            500                 505                 510         


Cys Ile Val Tyr Pro Phe Arg Cys Val Arg Pro Gly Lys Cys Arg Thr 
        515                 520                 525             


Ile Thr Val Leu Ile Leu Ile Trp Ile Thr Gly Phe Ile Val Ala Phe 
    530                 535                 540                 


Ile Pro Leu Ser Asn Lys Glu Phe Phe Lys Asn Tyr Tyr Gly Thr Asn 
545                 550                 555                 560 


Gly Val Cys Phe Pro Leu His Ser Glu Asp Thr Glu Ser Ile Gly Ala 
                565                 570                 575     


Gln Ile Tyr Ser Val Ala Ile Phe Leu Gly Ile Asn Leu Ala Ala Phe 
            580                 585                 590         


Ile Ile Ile Val Phe Ser Tyr Gly Ser Met Phe Tyr Ser Val His Gln 
        595                 600                 605             


Ser Ala Ile Thr Ala Thr Glu Ile Arg Asn Gln Val Lys Lys Glu Met 
    610                 615                 620                 


Ile Leu Ala Lys Arg Phe Phe Phe Ile Val Phe Thr Asp Ala Leu Cys 
625                 630                 635                 640 


Trp Ile Pro Ile Phe Val Val Lys Phe Leu Ser Leu Leu Gln Val Glu 
                645                 650                 655     


Ile Pro Gly Thr Ile Thr Ser Trp Val Val Ile Phe Ile Leu Pro Ile 
            660                 665                 670         


Asn Ser Ala Leu Asn Pro Ile Leu Tyr Thr Leu Thr Thr Arg Pro Phe 
        675                 680                 685             


Lys Glu Met Ile His Arg Phe Trp Tyr Asn Tyr Arg Gln Arg Lys Ser 
    690                 695                 700                 


Met Asp Ser Lys Gly Gln Lys Thr Tyr Ala Pro Ser Phe Ile Trp Val 
705                 710                 715                 720 


Glu Met Trp Pro Leu Gln Glu Met Pro Pro Glu Leu Met Lys Pro Asp 
                725                 730                 735     


Leu Phe Thr Tyr Pro Cys Glu Met Ser Leu Ile Ser Gln Ser Thr Arg 
            740                 745                 750         


Leu Asn Ser Tyr Ser 
        755         


<210>  4813
<211>  915
<212>  PRT
<213>  Homo sapiens

<400>  4813

Met Gly Arg Pro Arg Leu Thr Leu Val Cys Gln Val Ser Ile Ile Ile 
1               5                   10                  15      


Ser Ala Arg Asp Leu Ser Met Asn Asn Leu Thr Glu Leu Gln Pro Gly 
            20                  25                  30          


Leu Phe His His Leu Arg Phe Leu Glu Glu Leu Arg Leu Ser Gly Asn 
        35                  40                  45              


His Leu Ser His Ile Pro Gly Gln Ala Phe Ser Gly Leu Tyr Ser Leu 
    50                  55                  60                  


Lys Ile Leu Met Leu Gln Asn Asn Gln Leu Gly Gly Ile Pro Ala Glu 
65                  70                  75                  80  


Ala Leu Trp Glu Leu Pro Ser Leu Gln Ser Leu Arg Leu Asp Ala Asn 
                85                  90                  95      


Leu Ile Ser Leu Val Pro Glu Arg Ser Phe Glu Gly Leu Ser Ser Leu 
            100                 105                 110         


Arg His Leu Trp Leu Asp Asp Asn Ala Leu Thr Glu Ile Pro Val Arg 
        115                 120                 125             


Ala Leu Asn Asn Leu Pro Ala Leu Gln Ala Met Thr Leu Ala Leu Asn 
    130                 135                 140                 


Arg Ile Ser His Ile Pro Asp Tyr Ala Phe Gln Asn Leu Thr Ser Leu 
145                 150                 155                 160 


Val Val Leu His Leu His Asn Asn Arg Ile Gln His Leu Gly Thr His 
                165                 170                 175     


Ser Phe Glu Gly Leu His Asn Leu Glu Thr Leu Asp Leu Asn Tyr Asn 
            180                 185                 190         


Lys Leu Gln Glu Phe Pro Val Ala Ile Arg Thr Leu Gly Arg Leu Gln 
        195                 200                 205             


Glu Leu Gly Phe His Asn Asn Asn Ile Lys Ala Ile Pro Glu Lys Ala 
    210                 215                 220                 


Phe Met Gly Asn Pro Leu Leu Gln Thr Ile His Phe Tyr Asp Asn Pro 
225                 230                 235                 240 


Ile Gln Phe Val Gly Arg Ser Ala Phe Gln Tyr Leu Pro Lys Leu His 
                245                 250                 255     


Thr Leu Ser Leu Asn Gly Ala Met Asp Ile Gln Glu Phe Pro Asp Leu 
            260                 265                 270         


Lys Gly Thr Thr Ser Leu Glu Ile Leu Thr Leu Thr Arg Ala Gly Ile 
        275                 280                 285             


Arg Leu Leu Pro Ser Gly Met Cys Gln Gln Leu Pro Arg Leu Arg Val 
    290                 295                 300                 


Leu Glu Leu Ser His Asn Gln Ile Glu Glu Leu Pro Ser Leu His Arg 
305                 310                 315                 320 


Cys Gln Lys Leu Glu Glu Ile Gly Leu Gln His Asn Arg Ile Trp Glu 
                325                 330                 335     


Ile Gly Ala Asp Thr Phe Ser Gln Leu Ser Ser Leu Gln Ala Leu Asp 
            340                 345                 350         


Leu Ser Trp Asn Ala Ile Arg Ser Ile His Pro Glu Ala Phe Ser Thr 
        355                 360                 365             


Leu His Ser Leu Val Lys Leu Asp Leu Thr Asp Asn Gln Leu Thr Thr 
    370                 375                 380                 


Leu Pro Leu Ala Gly Leu Gly Gly Leu Met His Leu Lys Leu Lys Gly 
385                 390                 395                 400 


Asn Leu Ala Leu Ser Gln Ala Phe Ser Lys Asp Ser Phe Pro Lys Leu 
                405                 410                 415     


Arg Ile Leu Glu Val Pro Tyr Ala Tyr Gln Cys Cys Pro Tyr Gly Met 
            420                 425                 430         


Cys Ala Ser Phe Phe Lys Ala Ser Gly Gln Trp Glu Ala Glu Asp Leu 
        435                 440                 445             


His Leu Asp Asp Glu Glu Ser Ser Lys Arg Pro Leu Gly Leu Leu Ala 
    450                 455                 460                 


Arg Gln Ala Glu Asn His Tyr Asp Gln Asp Leu Asp Glu Leu Gln Leu 
465                 470                 475                 480 


Glu Met Glu Asp Ser Lys Pro His Pro Ser Val Gln Cys Ser Pro Thr 
                485                 490                 495     


Pro Gly Pro Phe Lys Pro Cys Glu Tyr Leu Phe Glu Ser Trp Gly Ile 
            500                 505                 510         


Arg Leu Ala Val Trp Ala Ile Val Leu Leu Ser Val Leu Cys Asn Gly 
        515                 520                 525             


Leu Val Leu Leu Thr Val Phe Ala Gly Gly Pro Val Pro Leu Pro Pro 
    530                 535                 540                 


Val Lys Phe Val Val Gly Ala Ile Ala Gly Ala Asn Thr Leu Thr Gly 
545                 550                 555                 560 


Ile Ser Cys Gly Leu Leu Ala Ser Val Asp Ala Leu Thr Phe Gly Gln 
                565                 570                 575     


Phe Ser Glu Tyr Gly Ala Arg Trp Glu Thr Gly Leu Gly Cys Arg Ala 
            580                 585                 590         


Thr Gly Phe Leu Ala Val Leu Gly Ser Glu Ala Ser Val Leu Leu Leu 
        595                 600                 605             


Thr Leu Ala Ala Val Gln Cys Ser Val Ser Val Ser Cys Val Arg Ala 
    610                 615                 620                 


Tyr Gly Lys Ser Pro Ser Leu Gly Ser Val Arg Ala Gly Val Leu Gly 
625                 630                 635                 640 


Cys Leu Ala Leu Ala Gly Leu Ala Ala Ala Leu Pro Leu Ala Ser Val 
                645                 650                 655     


Gly Glu Tyr Gly Ala Ser Pro Leu Cys Leu Pro Tyr Ala Pro Pro Glu 
            660                 665                 670         


Gly Gln Pro Ala Ala Leu Gly Phe Thr Val Ala Leu Val Met Met Asn 
        675                 680                 685             


Ser Phe Cys Phe Leu Val Val Ala Gly Ala Tyr Ile Lys Leu Tyr Cys 
    690                 695                 700                 


Asp Leu Pro Arg Gly Asp Phe Glu Ala Val Trp Asp Cys Ala Met Val 
705                 710                 715                 720 


Arg His Val Ala Trp Leu Ile Phe Ala Asp Gly Leu Leu Tyr Cys Pro 
                725                 730                 735     


Val Ala Phe Leu Ser Phe Ala Ser Met Leu Gly Leu Phe Pro Val Thr 
            740                 745                 750         


Pro Glu Ala Val Lys Ser Val Leu Leu Val Val Leu Pro Leu Pro Ala 
        755                 760                 765             


Cys Leu Asn Pro Leu Leu Tyr Leu Leu Phe Asn Pro His Phe Arg Asp 
    770                 775                 780                 


Asp Leu Arg Arg Leu Arg Pro Arg Ala Gly Asp Ser Gly Pro Leu Ala 
785                 790                 795                 800 


Tyr Ala Ala Ala Gly Glu Leu Glu Lys Ser Ser Cys Asp Ser Thr Gln 
                805                 810                 815     


Ala Leu Val Ala Phe Ser Asp Val Asp Leu Ile Leu Glu Ala Ser Glu 
            820                 825                 830         


Ala Gly Arg Pro Pro Gly Leu Glu Thr Tyr Gly Phe Pro Ser Val Thr 
        835                 840                 845             


Leu Ile Ser Cys Gln Gln Pro Gly Ala Pro Arg Leu Glu Gly Ser His 
    850                 855                 860                 


Cys Val Glu Pro Glu Gly Asn His Phe Gly Asn Pro Gln Pro Ser Met 
865                 870                 875                 880 


Asp Gly Glu Leu Leu Leu Arg Ala Glu Gly Ser Thr Pro Ala Gly Gly 
                885                 890                 895     


Gly Leu Ser Gly Gly Gly Gly Phe Gln Pro Ser Gly Leu Ala Phe Ala 
            900                 905                 910         


Ser His Val 
        915 


<210>  4814
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  4814

Met Ala Ser Pro Arg Thr Val Thr Ile Val Ala Leu Ser Val Ala Leu 
1               5                   10                  15      


Gly Leu Phe Phe Val Phe Met Gly Thr Ile Lys Leu Thr Pro Arg Leu 
            20                  25                  30          


Ser Lys Asp Ala Tyr Ser Glu Met Lys Arg Ala Tyr Lys Ser Tyr Val 
        35                  40                  45              


Arg Ala Leu Pro Leu Leu Lys Lys Met Gly Ile Asn Ser Ile Leu Leu 
    50                  55                  60                  


Arg Lys Ser Ile Gly Ala Leu Glu Val Ala Cys Gly Ile Val Met Thr 
65                  70                  75                  80  


Leu Val Pro Gly Arg Pro Lys Asp Val Ala Asn Phe Phe Leu Leu Leu 
                85                  90                  95      


Leu Val Leu Ala Val Leu Phe Phe His Gln Leu Val Gly Asp Pro Leu 
            100                 105                 110         


Lys Arg Tyr Ala His Ala Leu Val Phe Gly Ile Leu Leu Thr Cys Arg 
        115                 120                 125             


Leu Leu Ile Ala Arg Lys Pro Glu Asp Arg Ser Ser Glu Lys Lys Pro 
    130                 135                 140                 


Leu Pro Gly Asn Ala Glu Glu Gln Pro Ser Leu Tyr Glu Lys Ala Pro 
145                 150                 155                 160 


Gln Gly Lys Val Lys Val Ser 
                165         


<210>  4815
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  4815

Met Ala Ala Arg Pro Leu Pro Val Ser Pro Ala Arg Ala Leu Leu Leu 
1               5                   10                  15      


Ala Leu Ala Gly Ala Leu Leu Ala Pro Cys Glu Ala Arg Gly Val Ser 
            20                  25                  30          


Leu Trp Asn Gln Gly Arg Ala Asp Glu Val Val Ser Ala Ser Val Gly 
        35                  40                  45              


Ser Gly Asp Leu Trp Ile Pro Val Lys Ser Phe Asp Ser Lys Asn His 
    50                  55                  60                  


Pro Glu Val Leu Asn Ile Arg Leu Gln Arg Glu Ser Lys Glu Leu Ile 
65                  70                  75                  80  


Ile Asn Leu Glu Arg Asn Glu Gly Leu Ile Ala Ser Ser Phe Thr Glu 
                85                  90                  95      


Thr His Tyr Leu Gln Asp Gly Thr Asp Val Ser Leu Ala Arg Asn Tyr 
            100                 105                 110         


Thr Val Ile Leu Gly His Cys Tyr Tyr His Gly His Val Arg Gly Tyr 
        115                 120                 125             


Ser Asp Ser Ala Val Ser Leu Ser Thr Cys Ser Gly Leu Arg Gly Leu 
    130                 135                 140                 


Ile Val Phe Glu Asn Glu Ser Tyr Val Leu Glu Pro Met Lys Ser Ala 
145                 150                 155                 160 


Thr Asn Arg Tyr Lys Leu Phe Pro Ala Lys Lys Leu Lys Ser Val Arg 
                165                 170                 175     


Gly Ser Cys Gly Ser His His Asn Thr Pro Asn Leu Ala Ala Lys Asn 
            180                 185                 190         


Val Phe Pro Pro Pro Ser Gln Thr Trp Ala Arg Arg His Lys Arg Glu 
        195                 200                 205             


Thr Leu Lys Ala Thr Lys Tyr Val Glu Leu Val Ile Val Ala Asp Asn 
    210                 215                 220                 


Arg Glu Phe Gln Arg Gln Gly Lys Asp Leu Glu Lys Val Lys Gln Arg 
225                 230                 235                 240 


Leu Ile Glu Ile Ala Asn His Val Asp Lys Phe Tyr Arg Pro Leu Asn 
                245                 250                 255     


Ile Arg Ile Val Leu Val Gly Val Glu Val Trp Asn Asp Met Asp Lys 
            260                 265                 270         


Cys Ser Val Ser Gln Asp Pro Phe Thr Ser Leu His Glu Phe Leu Asp 
        275                 280                 285             


Trp Arg Lys Met Lys Leu Leu Pro Arg Lys Ser His Asp Asn Ala Gln 
    290                 295                 300                 


Leu Val Ser Gly Val Tyr Phe Gln Gly Thr Thr Ile Gly Met Ala Pro 
305                 310                 315                 320 


Ile Met Ser Met Cys Thr Ala Asp Gln Ser Gly Gly Ile Val Met Asp 
                325                 330                 335     


His Ser Asp Asn Pro Leu Gly Ala Ala Val Thr Leu Ala His Glu Leu 
            340                 345                 350         


Gly His Asn Phe Gly Met Asn His Asp Thr Leu Asp Arg Gly Cys Ser 
        355                 360                 365             


Cys Gln Met Ala Val Glu Lys Gly Gly Cys Ile Met Asn Ala Ser Thr 
    370                 375                 380                 


Gly Tyr Pro Phe Pro Met Val Phe Ser Ser Cys Ser Arg Lys Asp Leu 
385                 390                 395                 400 


Glu Thr Ser Leu Glu Lys Gly Met Gly Val Cys Leu Phe Asn Leu Pro 
                405                 410                 415     


Glu Val Arg Glu Ser Phe Gly Gly Gln Lys Cys Gly Asn Arg Phe Val 
            420                 425                 430         


Glu Glu Gly Glu Glu Cys Asp Cys Gly Glu Pro Glu Glu Cys Met Asn 
        435                 440                 445             


Arg Cys Cys Asn Ala Thr Thr Cys Thr Leu Lys Pro Asp Ala Val Cys 
    450                 455                 460                 


Ala His Gly Leu Cys Cys Glu Asp Cys Gln Leu Lys Pro Ala Gly Thr 
465                 470                 475                 480 


Ala Cys Arg Asp Ser Ser Asn Ser Cys Asp Leu Pro Glu Phe Cys Thr 
                485                 490                 495     


Gly Ala Ser Pro His Cys Pro Ala Asn Val Tyr Leu His Asp Gly His 
            500                 505                 510         


Ser Cys Gln Asp Val Asp Gly Tyr Cys Tyr Asn Gly Ile Cys Gln Thr 
        515                 520                 525             


His Glu Gln Gln Cys Val Thr Leu Trp Gly Pro Gly Ala Lys Pro Ala 
    530                 535                 540                 


Pro Gly Ile Cys Phe Glu Arg Val Asn Ser Ala Gly Asp Pro Tyr Gly 
545                 550                 555                 560 


Asn Cys Gly Lys Val Ser Lys Ser Ser Phe Ala Lys Cys Glu Met Arg 
                565                 570                 575     


Asp Ala Lys Cys Gly Lys Ile Gln Cys Gln Gly Gly Ala Ser Arg Pro 
            580                 585                 590         


Val Ile Gly Thr Asn Ala Val Ser Ile Glu Thr Asn Ile Pro Leu Gln 
        595                 600                 605             


Gln Gly Gly Arg Ile Leu Cys Arg Gly Thr His Val Tyr Leu Gly Asp 
    610                 615                 620                 


Asp Met Pro Asp Pro Gly Leu Val Leu Ala Gly Thr Lys Cys Ala Asp 
625                 630                 635                 640 


Gly Lys Ile Cys Leu Asn Arg Gln Cys Gln Asn Ile Ser Val Phe Gly 
                645                 650                 655     


Val His Glu Cys Ala Met Gln Cys His Gly Arg Gly Val Cys Asn Asn 
            660                 665                 670         


Arg Lys Asn Cys His Cys Glu Ala His Trp Ala Pro Pro Phe Cys Asp 
        675                 680                 685             


Lys Phe Gly Phe Gly Gly Ser Thr Asp Ser Gly Pro Ile Arg Gln Ala 
    690                 695                 700                 


Glu Ala Arg Gln Glu Ala Ala Glu Ser Asn Arg Glu Arg Gly Gln Gly 
705                 710                 715                 720 


Gln Glu Pro Val Gly Ser Gln Glu His Ala Ser Thr Ala Ser Leu Thr 
                725                 730                 735     


Leu Ile 
        


<210>  4816
<211>  409
<212>  PRT
<213>  Homo sapiens

<400>  4816

Met Asp Arg Leu Lys Ser His Leu Thr Val Cys Phe Leu Pro Ser Val 
1               5                   10                  15      


Pro Phe Leu Ile Leu Val Ser Thr Leu Ala Thr Ala Lys Ser Val Thr 
            20                  25                  30          


Asn Ser Thr Leu Asn Gly Thr Asn Val Val Leu Gly Ser Val Pro Val 
        35                  40                  45              


Ile Ile Ala Arg Thr Asp His Ile Ile Val Lys Glu Gly Asn Ser Ala 
    50                  55                  60                  


Leu Ile Asn Cys Ser Val Tyr Gly Ile Pro Asp Pro Gln Phe Lys Trp 
65                  70                  75                  80  


Tyr Asn Ser Ile Gly Lys Leu Leu Lys Glu Glu Glu Asp Glu Lys Glu 
                85                  90                  95      


Arg Gly Gly Gly Lys Trp Gln Met His Asp Ser Gly Leu Leu Asn Ile 
            100                 105                 110         


Thr Lys Val Ser Phe Ser Asp Arg Gly Lys Tyr Thr Cys Val Ala Ser 
        115                 120                 125             


Asn Ile Tyr Gly Thr Val Asn Asn Thr Val Thr Leu Arg Val Ile Phe 
    130                 135                 140                 


Thr Ser Gly Asp Met Gly Val Tyr Tyr Met Val Val Cys Leu Val Ala 
145                 150                 155                 160 


Phe Thr Ile Val Met Val Leu Asn Ile Thr Arg Leu Cys Met Met Ser 
                165                 170                 175     


Ser His Leu Lys Lys Thr Glu Lys Ala Ile Asn Glu Phe Phe Arg Thr 
            180                 185                 190         


Glu Gly Ala Glu Lys Leu Gln Lys Ala Phe Glu Ile Ala Lys Arg Ile 
        195                 200                 205             


Pro Ile Ile Thr Ser Ala Lys Thr Leu Glu Leu Ala Lys Val Thr Gln 
    210                 215                 220                 


Phe Lys Thr Met Glu Phe Ala Arg Tyr Ile Glu Glu Leu Ala Arg Ser 
225                 230                 235                 240 


Val Pro Leu Pro Pro Leu Ile Met Asn Cys Arg Thr Ile Met Glu Glu 
                245                 250                 255     


Ile Met Glu Val Val Gly Leu Glu Glu Gln Gly Gln Asn Phe Val Arg 
            260                 265                 270         


His Thr Pro Glu Gly Gln Glu Ala Ala Asp Arg Asp Glu Val Tyr Thr 
        275                 280                 285             


Ile Pro Asn Ser Leu Lys Arg Ser Asp Ser Pro Ala Ala Asp Ser Asp 
    290                 295                 300                 


Ala Ser Ser Leu His Glu Gln Pro Gln Gln Ile Ala Ile Lys Val Ser 
305                 310                 315                 320 


Val His Pro Gln Ser Lys Lys Glu His Ala Asp Asp Gln Glu Gly Gly 
                325                 330                 335     


Gln Phe Glu Val Lys Asp Val Glu Glu Thr Glu Leu Ser Ala Glu His 
            340                 345                 350         


Ser Pro Glu Thr Ala Glu Pro Ser Thr Asp Val Thr Ser Thr Glu Leu 
        355                 360                 365             


Thr Ser Glu Glu Pro Thr Pro Val Glu Val Pro Asp Lys Val Leu Pro 
    370                 375                 380                 


Pro Ala Tyr Leu Glu Ala Thr Glu Pro Ala Val Thr His Asp Lys Asn 
385                 390                 395                 400 


Thr Cys Ile Ile Tyr Glu Ser His Val 
                405                 


<210>  4817
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  4817

Met Gly Ile Gly Lys Ser Lys Ile Asn Ser Cys Pro Leu Ser Leu Ser 
1               5                   10                  15      


Trp Gly Lys Arg His Ser Val Asp Thr Ser Pro Gly Tyr His Glu Ser 
            20                  25                  30          


Asp Ser Lys Lys Ser Glu Asp Leu Ser Leu Cys Asn Val Ala Glu His 
        35                  40                  45              


Ser Asn Thr Thr Glu Gly Pro Thr Gly Lys Gln Glu Gly Ala Gln Ser 
    50                  55                  60                  


Val Glu Glu Met Phe Glu Glu Glu Ala Glu Glu Glu Val Phe Leu Lys 
65                  70                  75                  80  


Phe Val Ile Leu His Ala Glu Asp Asp Thr Asp Glu Ala Leu Arg Val 
                85                  90                  95      


Gln Asn Leu Leu Gln Asp Asp Phe Gly Ile Lys Pro Gly Ile Ile Phe 
            100                 105                 110         


Ala Glu Met Pro Cys Gly Arg Gln His Leu Gln Asn Leu Asp Asp Ala 
        115                 120                 125             


Val Asn Gly Ser Ala Trp Thr Ile Leu Leu Leu Thr Glu Asn Phe Leu 
    130                 135                 140                 


Arg Asp Thr Trp Cys Asn Phe Gln Phe Tyr Thr Ser Leu Met Asn Ser 
145                 150                 155                 160 


Val Asn Arg Gln His Lys Tyr Asn Ser Val Ile Pro Met Arg Pro Leu 
                165                 170                 175     


Asn Asn Pro Leu Pro Arg Glu Arg Thr Pro Phe Ala Leu Gln Thr Ile 
            180                 185                 190         


Asn Ala Leu Glu Glu Glu Ser Arg Gly Phe Pro Thr Gln Val Glu Arg 
        195                 200                 205             


Ile Phe Gln Glu Ser Val Tyr Lys Thr Gln Gln Thr Ile Trp Lys Glu 
    210                 215                 220                 


Thr Arg Asn Met Val Gln Arg Gln Phe Ile Ala 
225                 230                 235 


<210>  4818
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  4818

Met Ser Pro His Pro Thr Ala Leu Leu Gly Leu Val Leu Cys Leu Ala 
1               5                   10                  15      


Gln Thr Ile His Thr Gln Glu Glu Asp Leu Pro Arg Pro Ser Ile Ser 
            20                  25                  30          


Ala Glu Pro Gly Thr Val Ile Pro Leu Gly Ser His Val Thr Phe Val 
        35                  40                  45              


Cys Arg Gly Pro Val Gly Val Gln Thr Phe Arg Leu Glu Arg Asp Ser 
    50                  55                  60                  


Arg Ser Thr Tyr Asn Asp Thr Glu Asp Val Ser Gln Ala Ser Pro Ser 
65                  70                  75                  80  


Glu Ser Glu Ala Arg Phe Arg Ile Asp Ser Val Arg Glu Gly Asn Ala 
                85                  90                  95      


Gly Leu Tyr Arg Cys Ile Tyr Tyr Lys Pro Pro Lys Trp Ser Glu Gln 
            100                 105                 110         


Ser Asp Tyr Leu Glu Leu Leu Val Lys Gly Pro Thr Gln Arg Pro Ser 
        115                 120                 125             


Asp Asn Ser His Asn Glu His Ala Pro Ala Ser Gln Gly Leu Lys Ala 
    130                 135                 140                 


Glu His Leu Tyr Ile Leu Ile Gly Val Ser Val Val Phe Leu Phe Cys 
145                 150                 155                 160 


Leu Leu Leu Leu Val Leu Phe Cys Leu His Arg Gln Asn Gln Ile Lys 
                165                 170                 175     


Gln Gly Pro Pro Arg Ser Lys Asp Glu Glu Gln Lys Pro Gln Gln Arg 
            180                 185                 190         


Pro Asp Leu Ala Val Asp Val Leu Glu Arg Thr Ala Asp Lys Ala Thr 
        195                 200                 205             


Val Asn Gly Leu Pro Glu Lys Asp Arg Glu Thr Asp Thr Ser Ala Leu 
    210                 215                 220                 


Ala Ala Gly Ser Ser Gln Glu Val Thr Tyr Ala Gln Leu Asp His Trp 
225                 230                 235                 240 


Ala Leu Thr Gln Arg Thr Ala Arg Ala Val Ser Pro Gln Ser Thr Lys 
                245                 250                 255     


Pro Met Ala Glu Ser Ile Thr Tyr Ala Ala Val Ala Arg His 
            260                 265                 270 


<210>  4819
<211>  823
<212>  PRT
<213>  Homo sapiens

<400>  4819

Met Gln Ala Ala Val Ala Val Ser Val Pro Phe Leu Leu Leu Cys Val 
1               5                   10                  15      


Leu Gly Thr Cys Pro Pro Ala Arg Cys Gly Gln Ala Gly Asp Ala Ser 
            20                  25                  30          


Leu Met Glu Leu Glu Lys Arg Lys Glu Asn Arg Phe Val Glu Arg Gln 
        35                  40                  45              


Ser Ile Val Pro Leu Arg Leu Ile Tyr Arg Ser Gly Gly Glu Asp Glu 
    50                  55                  60                  


Ser Arg His Asp Ala Leu Asp Thr Arg Val Arg Gly Asp Leu Gly Gly 
65                  70                  75                  80  


Pro Gln Leu Thr His Val Asp Gln Ala Ser Phe Gln Val Asp Ala Phe 
                85                  90                  95      


Gly Thr Ser Phe Ile Leu Asp Val Val Leu Asn His Asp Leu Leu Ser 
            100                 105                 110         


Ser Glu Tyr Ile Glu Arg His Ile Glu His Gly Gly Lys Thr Val Glu 
        115                 120                 125             


Val Lys Gly Gly Glu His Cys Tyr Tyr Gln Gly His Ile Arg Gly Asn 
    130                 135                 140                 


Pro Asp Ser Phe Val Ala Leu Ser Thr Cys His Gly Leu His Gly Met 
145                 150                 155                 160 


Phe Tyr Asp Gly Asn His Thr Tyr Leu Ile Glu Pro Glu Glu Asn Asp 
                165                 170                 175     


Thr Thr Gln Glu Asp Phe His Phe His Ser Val Tyr Lys Ser Arg Leu 
            180                 185                 190         


Phe Glu Phe Ser Leu Asp Asp Leu Pro Ser Glu Phe Gln Gln Val Asn 
        195                 200                 205             


Ile Thr Pro Ser Lys Phe Ile Leu Lys Pro Arg Pro Lys Arg Ser Lys 
    210                 215                 220                 


Arg Gln Leu Arg Arg Tyr Pro Arg Asn Val Glu Glu Glu Thr Lys Tyr 
225                 230                 235                 240 


Ile Glu Leu Met Ile Val Asn Asp His Leu Met Phe Lys Lys His Arg 
                245                 250                 255     


Leu Ser Val Val His Thr Asn Thr Tyr Ala Lys Ser Val Val Asn Met 
            260                 265                 270         


Ala Asp Leu Ile Tyr Lys Asp Gln Leu Lys Thr Arg Ile Val Leu Val 
        275                 280                 285             


Ala Met Glu Thr Trp Ala Thr Asp Asn Lys Phe Ala Ile Ser Glu Asn 
    290                 295                 300                 


Pro Leu Ile Thr Leu Arg Glu Phe Met Lys Tyr Arg Arg Asp Phe Ile 
305                 310                 315                 320 


Lys Glu Lys Ser Asp Ala Val His Leu Phe Ser Gly Ser Gln Phe Glu 
                325                 330                 335     


Ser Ser Arg Ser Gly Ala Ala Tyr Ile Gly Gly Ile Cys Ser Leu Leu 
            340                 345                 350         


Lys Gly Gly Gly Val Asn Glu Phe Gly Lys Thr Asp Leu Met Ala Val 
        355                 360                 365             


Thr Leu Ala Gln Ser Leu Ala His Asn Ile Gly Ile Ile Ser Asp Lys 
    370                 375                 380                 


Arg Lys Leu Ala Ser Gly Glu Cys Lys Cys Glu Asp Thr Trp Ser Gly 
385                 390                 395                 400 


Cys Ile Met Gly Asp Thr Gly Tyr Tyr Leu Pro Lys Lys Phe Thr Gln 
                405                 410                 415     


Cys Asn Ile Glu Glu Tyr His Asp Phe Leu Asn Ser Gly Gly Gly Ala 
            420                 425                 430         


Cys Leu Phe Asn Lys Pro Ser Lys Leu Leu Asp Pro Pro Glu Cys Gly 
        435                 440                 445             


Asn Gly Phe Ile Glu Thr Gly Glu Glu Cys Asp Cys Gly Thr Pro Ala 
    450                 455                 460                 


Glu Cys Val Leu Glu Gly Ala Glu Cys Cys Lys Lys Cys Thr Leu Thr 
465                 470                 475                 480 


Gln Asp Ser Gln Cys Ser Asp Gly Leu Cys Cys Lys Lys Cys Lys Phe 
                485                 490                 495     


Gln Pro Met Gly Thr Val Cys Arg Glu Ala Val Asn Asp Cys Asp Ile 
            500                 505                 510         


Arg Glu Thr Cys Ser Gly Asn Ser Ser Gln Cys Ala Pro Asn Ile His 
        515                 520                 525             


Lys Met Asp Gly Tyr Ser Cys Asp Gly Val Gln Gly Ile Cys Phe Gly 
    530                 535                 540                 


Gly Arg Cys Lys Thr Arg Asp Arg Gln Cys Lys Tyr Ile Trp Gly Gln 
545                 550                 555                 560 


Lys Val Thr Ala Ser Asp Lys Tyr Cys Tyr Glu Lys Leu Asn Ile Glu 
                565                 570                 575     


Gly Thr Glu Lys Gly Asn Cys Gly Lys Asp Lys Asp Thr Trp Ile Gln 
            580                 585                 590         


Cys Asn Lys Arg Asp Val Leu Cys Gly Tyr Leu Leu Cys Thr Asn Ile 
        595                 600                 605             


Gly Asn Ile Pro Arg Leu Gly Glu Leu Asp Gly Glu Ile Thr Ser Thr 
    610                 615                 620                 


Leu Val Val Gln Gln Gly Arg Thr Leu Asn Cys Ser Gly Gly His Val 
625                 630                 635                 640 


Lys Leu Glu Glu Asp Val Asp Leu Gly Tyr Val Glu Asp Gly Thr Pro 
                645                 650                 655     


Cys Gly Pro Gln Met Met Cys Leu Glu His Arg Cys Leu Pro Val Ala 
            660                 665                 670         


Ser Phe Asn Phe Ser Thr Cys Leu Ser Ser Lys Glu Gly Thr Ile Cys 
        675                 680                 685             


Ser Gly Asn Gly Val Cys Ser Asn Glu Leu Lys Cys Val Cys Asn Arg 
    690                 695                 700                 


His Trp Ile Gly Ser Asp Cys Asn Thr Tyr Phe Pro His Asn Asp Asp 
705                 710                 715                 720 


Ala Lys Thr Gly Ile Thr Leu Ser Gly Asn Gly Val Ala Gly Thr Asn 
                725                 730                 735     


Ile Ile Ile Gly Ile Ile Ala Gly Thr Ile Leu Val Leu Ala Leu Ile 
            740                 745                 750         


Leu Gly Ile Thr Ala Trp Gly Tyr Lys Asn Tyr Arg Glu Gln Arg Ser 
        755                 760                 765             


Asn Gly Leu Ser His Ser Trp Ser Glu Arg Ile Pro Asp Thr Lys His 
    770                 775                 780                 


Ile Ser Asp Ile Cys Glu Asn Gly Arg Pro Arg Ser Asn Ser Trp Gln 
785                 790                 795                 800 


Gly Asn Leu Gly Gly Asn Lys Lys Lys Ile Arg Gly Lys Arg Phe Arg 
                805                 810                 815     


Pro Arg Ser Asn Ser Thr Glu 
            820             


<210>  4820
<211>  899
<212>  PRT
<213>  Homo sapiens

<400>  4820

Met Gln Ala Ala Val Ala Val Ser Val Pro Phe Leu Leu Leu Cys Val 
1               5                   10                  15      


Leu Gly Thr Cys Pro Pro Ala Arg Cys Gly Gln Ala Gly Asp Ala Ser 
            20                  25                  30          


Leu Met Glu Leu Glu Lys Arg Lys Glu Asn Arg Phe Val Glu Arg Gln 
        35                  40                  45              


Ser Ile Val Pro Leu Arg Leu Ile Tyr Arg Ser Gly Gly Glu Asp Glu 
    50                  55                  60                  


Ser Arg His Asp Ala Leu Asp Thr Arg Val Arg Gly Asp Leu Gly Gly 
65                  70                  75                  80  


Pro Gln Leu Thr His Val Asp Gln Ala Ser Phe Gln Val Asp Ala Phe 
                85                  90                  95      


Gly Thr Ser Phe Ile Leu Asp Val Val Leu Asn His Asp Leu Leu Ser 
            100                 105                 110         


Ser Glu Tyr Ile Glu Arg His Ile Glu His Gly Gly Lys Thr Val Glu 
        115                 120                 125             


Val Lys Gly Gly Glu His Cys Tyr Tyr Gln Gly His Ile Arg Gly Asn 
    130                 135                 140                 


Pro Asp Ser Phe Val Ala Leu Ser Thr Cys His Gly Leu His Gly Met 
145                 150                 155                 160 


Phe Tyr Asp Gly Asn His Thr Tyr Leu Ile Glu Pro Glu Glu Asn Asp 
                165                 170                 175     


Thr Thr Gln Glu Asp Phe His Phe His Ser Val Tyr Lys Ser Arg Leu 
            180                 185                 190         


Phe Glu Phe Ser Leu Asp Asp Leu Pro Ser Glu Phe Gln Gln Val Asn 
        195                 200                 205             


Ile Thr Pro Ser Lys Phe Ile Leu Lys Pro Arg Pro Lys Arg Ser Lys 
    210                 215                 220                 


Arg Gln Leu Arg Arg Tyr Pro Arg Asn Val Glu Glu Glu Thr Lys Tyr 
225                 230                 235                 240 


Ile Glu Leu Met Ile Val Asn Asp His Leu Met Phe Lys Lys His Arg 
                245                 250                 255     


Leu Ser Val Val His Thr Asn Thr Tyr Ala Lys Ser Val Val Asn Met 
            260                 265                 270         


Ala Asp Leu Ile Tyr Lys Asp Gln Leu Lys Thr Arg Ile Val Leu Val 
        275                 280                 285             


Ala Met Glu Thr Trp Ala Thr Asp Asn Lys Phe Ala Ile Ser Glu Asn 
    290                 295                 300                 


Pro Leu Ile Thr Leu Arg Glu Phe Met Lys Tyr Arg Arg Asp Phe Ile 
305                 310                 315                 320 


Lys Glu Lys Ser Asp Ala Val His Leu Phe Ser Gly Ser Gln Phe Glu 
                325                 330                 335     


Ser Ser Arg Ser Gly Ala Ala Tyr Ile Gly Gly Ile Cys Ser Leu Leu 
            340                 345                 350         


Lys Gly Gly Gly Val Asn Glu Phe Gly Lys Thr Asp Leu Met Ala Val 
        355                 360                 365             


Thr Leu Ala Gln Ser Leu Ala His Asn Ile Gly Ile Ile Ser Asp Lys 
    370                 375                 380                 


Arg Lys Leu Ala Ser Gly Glu Cys Lys Cys Glu Asp Thr Trp Ser Gly 
385                 390                 395                 400 


Cys Ile Met Gly Asp Thr Gly Tyr Tyr Leu Pro Lys Lys Phe Thr Gln 
                405                 410                 415     


Cys Asn Ile Glu Glu Tyr His Asp Phe Leu Asn Ser Gly Gly Gly Ala 
            420                 425                 430         


Cys Leu Phe Asn Lys Pro Ser Lys Leu Leu Asp Pro Pro Glu Cys Gly 
        435                 440                 445             


Asn Gly Phe Ile Glu Thr Gly Glu Glu Cys Asp Cys Gly Thr Pro Ala 
    450                 455                 460                 


Glu Cys Val Leu Glu Gly Ala Glu Cys Cys Lys Lys Cys Thr Leu Thr 
465                 470                 475                 480 


Gln Asp Ser Gln Cys Ser Asp Gly Leu Cys Cys Lys Lys Cys Lys Phe 
                485                 490                 495     


Gln Pro Met Gly Thr Val Cys Arg Glu Ala Val Asn Asp Cys Asp Ile 
            500                 505                 510         


Arg Glu Thr Cys Ser Gly Asn Ser Ser Gln Cys Ala Pro Asn Ile His 
        515                 520                 525             


Lys Met Asp Gly Tyr Ser Cys Asp Gly Val Gln Gly Ile Cys Phe Gly 
    530                 535                 540                 


Gly Arg Cys Lys Thr Arg Asp Arg Gln Cys Lys Tyr Ile Trp Gly Gln 
545                 550                 555                 560 


Lys Val Thr Ala Ser Asp Lys Tyr Cys Tyr Glu Lys Leu Asn Ile Glu 
                565                 570                 575     


Gly Thr Glu Lys Gly Asn Cys Gly Lys Asp Lys Asp Thr Trp Ile Gln 
            580                 585                 590         


Cys Asn Lys Arg Asp Val Leu Cys Gly Tyr Leu Leu Cys Thr Asn Ile 
        595                 600                 605             


Gly Asn Ile Pro Arg Leu Gly Glu Leu Asp Gly Glu Ile Thr Ser Thr 
    610                 615                 620                 


Leu Val Val Gln Gln Gly Arg Thr Leu Asn Cys Ser Gly Gly His Val 
625                 630                 635                 640 


Lys Leu Glu Glu Asp Val Asp Leu Gly Tyr Val Glu Asp Gly Thr Pro 
                645                 650                 655     


Cys Gly Pro Gln Met Met Cys Leu Glu His Arg Cys Leu Pro Val Ala 
            660                 665                 670         


Ser Phe Asn Phe Ser Thr Cys Leu Ser Ser Lys Glu Gly Thr Ile Cys 
        675                 680                 685             


Ser Gly Asn Gly Val Cys Ser Asn Glu Leu Lys Cys Val Cys Asn Arg 
    690                 695                 700                 


His Trp Ile Gly Ser Asp Cys Asn Thr Tyr Phe Pro His Asn Asp Asp 
705                 710                 715                 720 


Ala Lys Thr Gly Ile Thr Leu Ser Gly Asn Gly Val Ala Gly Thr Asn 
                725                 730                 735     


Ile Ile Ile Gly Ile Ile Ala Gly Thr Ile Leu Val Leu Ala Leu Ile 
            740                 745                 750         


Leu Gly Ile Thr Ala Trp Gly Tyr Lys Asn Tyr Arg Glu Gln Arg Ser 
        755                 760                 765             


Asn Gly Leu Ser His Ser Trp Ser Glu Arg Ile Pro Asp Thr Lys His 
    770                 775                 780                 


Ile Ser Asp Ile Cys Glu Asn Gly Arg Pro Arg Ser Asn Ser Trp Gln 
785                 790                 795                 800 


Gly Asn Leu Gly Gly Asn Lys Lys Lys Ile Arg Gly Lys Arg Phe Arg 
                805                 810                 815     


Pro Arg Ser Asn Ser Thr Glu Tyr Leu Asn Pro Trp Phe Lys Arg Asp 
            820                 825                 830         


Tyr Asn Val Ala Lys Trp Val Glu Asp Val Asn Lys Asn Thr Glu Gly 
        835                 840                 845             


Pro Tyr Phe Arg Thr Leu Ser Pro Ala Lys Ser Pro Ser Ser Ser Thr 
    850                 855                 860                 


Gly Ser Ile Ala Ser Ser Arg Lys Tyr Pro Tyr Pro Met Pro Pro Leu 
865                 870                 875                 880 


Pro Asp Glu Asp Lys Lys Val Asn Arg Gln Ser Ala Arg Leu Trp Glu 
                885                 890                 895     


Thr Ser Ile 
            


<210>  4821
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  4821

Met Gln Ala Ala Val Ala Val Ser Val Pro Phe Leu Leu Leu Cys Val 
1               5                   10                  15      


Leu Gly Thr Cys Pro Pro Ala Arg Cys Gly Gln Ala Gly Asp Ala Ser 
            20                  25                  30          


Leu Met Glu Leu Glu Lys Arg Lys Glu Asn Arg Phe Val Glu Arg Gln 
        35                  40                  45              


Ser Ile Val Pro Leu Arg Leu Ile Tyr Arg Ser Gly Gly Glu Asp Glu 
    50                  55                  60                  


Ser Arg His Asp Ala Leu Asp Thr Arg Val Arg Gly Asp Leu Gly Gly 
65                  70                  75                  80  


Pro Gln Leu Thr His Val Asp Gln Ala Ser Phe Gln Val Asp Ala Phe 
                85                  90                  95      


Gly Thr Ser Phe Ile Leu Asp Val Val Leu Asn His Asp Leu Leu Ser 
            100                 105                 110         


Ser Glu Tyr Ile Glu Arg His Ile Glu His Gly Gly Lys Thr Val Glu 
        115                 120                 125             


Val Lys Gly Gly Glu His Cys Tyr Tyr Gln Gly His Ile Arg Gly Asn 
    130                 135                 140                 


Pro Asp Ser Phe Val Ala Leu Ser Thr Cys His Gly Leu His Gly Met 
145                 150                 155                 160 


Phe Tyr Asp Gly Asn His Thr Tyr Leu Ile Glu Pro Glu Glu Asn Asp 
                165                 170                 175     


Thr Thr Gln Glu Asp Phe His Phe His Ser Val Tyr Lys Ser Arg Leu 
            180                 185                 190         


Phe Glu Phe Ser Leu Asp Asp Leu Pro Ser Glu Phe Gln Gln Val Asn 
        195                 200                 205             


Ile Thr Pro Ser Lys Phe Ile Leu Lys Pro Arg Pro Lys Arg Ser Lys 
    210                 215                 220                 


Arg Gln Leu Arg Arg Tyr Pro Arg Asn Val Glu Glu Glu Thr Lys Tyr 
225                 230                 235                 240 


Ile Glu Leu Met Ile Val Asn Asp His Leu Met Phe Lys Lys His Arg 
                245                 250                 255     


Leu Ser Val Val His Thr Asn Thr Tyr Ala Lys Ser Val Val Asn Met 
            260                 265                 270         


Ala Asp Leu Ile Tyr Lys Asp Gln Leu Lys Thr Arg Ile Val Leu Val 
        275                 280                 285             


Ala Met Glu Thr Trp Ala Thr Asp Asn Lys Phe Ala Ile Ser Glu Asn 
    290                 295                 300                 


Pro Leu Ile Thr Leu Arg Glu Phe Met Lys Tyr Arg Arg Asp Phe Ile 
305                 310                 315                 320 


Lys Glu Lys Ser Asp Ala Val His Leu Phe Ser Gly Ser Gln Phe Glu 
                325                 330                 335     


Ser Ser Arg Ser Gly Ala Ala Tyr Ile Gly Gly Ile Cys Ser Leu Leu 
            340                 345                 350         


Lys Gly Gly Gly Val Asn Glu Phe Gly Lys Thr Asp Leu Met Ala Val 
        355                 360                 365             


Thr Leu Ala Gln Ser Leu Ala His Asn Ile Gly Ile Ile Ser Asp Lys 
    370                 375                 380                 


Arg Lys Leu Ala Ser Gly Glu Cys Lys Cys Glu Asp Thr Trp Ser Gly 
385                 390                 395                 400 


Cys Ile Met Gly Asp Thr Gly Tyr Tyr Leu Pro Lys Lys Phe Thr Gln 
                405                 410                 415     


Cys Asn Ile Glu Glu Tyr His Asp Phe Leu Asn Ser Gly Gly Gly Ala 
            420                 425                 430         


Cys Leu Phe Asn Lys Pro Ser Lys Leu Leu Asp Pro Pro Glu Cys Gly 
        435                 440                 445             


Asn Gly Phe Ile Glu Thr Gly Glu Glu Cys Asp Cys Gly Thr Pro Ala 
    450                 455                 460                 


Glu Cys Val Leu Glu Gly Ala Glu Cys Cys Lys Lys Cys Thr Leu Thr 
465                 470                 475                 480 


Gln Asp Ser Gln Cys Ser Asp Gly Leu Cys Cys Lys Lys Cys Lys Phe 
                485                 490                 495     


Gln Pro Met Gly Thr Val Cys Arg Glu Ala Val Asn Asp Cys Asp Ile 
            500                 505                 510         


Arg Glu Thr Cys Ser Gly Asn Ser Ser Gln Cys Ala Pro Asn Ile His 
        515                 520                 525             


Lys Met Asp Gly Tyr Ser Cys Asp Gly Val Gln Gly Ile Cys Phe Gly 
    530                 535                 540                 


Gly Arg Cys Lys Thr Arg Asp Arg Gln Cys Lys Tyr Ile Trp Gly Gln 
545                 550                 555                 560 


Lys Val Thr Ala Ser Asp Lys Tyr Cys Tyr Glu Lys Leu Asn Ile Glu 
                565                 570                 575     


Gly Thr Glu Lys Gly Asn Cys Gly Lys Asp Lys Asp Thr Trp Ile Gln 
            580                 585                 590         


Cys Asn Lys Arg Asp Val Leu Cys Gly Tyr Leu Leu Cys Thr Asn Ile 
        595                 600                 605             


Gly Asn Ile Pro Arg Leu Gly Glu Leu Asp Gly Glu Ile Thr Ser Thr 
    610                 615                 620                 


Leu Val Val Gln Gln Gly Arg Thr Leu Asn Cys Ser Gly Gly His Val 
625                 630                 635                 640 


Lys Leu Glu Glu Asp Val Asp Leu Gly Tyr Val Glu Asp Gly Thr Pro 
                645                 650                 655     


Cys Gly Pro Gln Met Met Cys Leu Glu His Arg Cys Leu Pro Val Ala 
            660                 665                 670         


Ser Phe Asn Phe Ser Thr Cys Leu Ser Ser Lys Glu Gly Thr Ile Cys 
        675                 680                 685             


Ser Gly Asn Gly Val Cys Ser Asn Glu Leu Lys Cys Val Cys Asn Arg 
    690                 695                 700                 


His Trp Ile Gly Ser Asp Cys Asn Thr Tyr Phe Pro His Asn Asp Asp 
705                 710                 715                 720 


Ala Lys Thr Gly Ile Thr Leu Ser Gly Asn Gly Val Ala Gly Thr Asn 
                725                 730                 735     


Ile Ile Ile Gly Ile Ile Ala Gly Thr Ile Leu Val Leu Ala Leu Ile 
            740                 745                 750         


Leu Gly Ile Thr Ala Trp Gly Tyr Lys Asn Tyr Arg Glu Gln Arg Gln 
        755                 760                 765             


Leu Pro Gln Gly Asp Tyr Val Lys Lys Pro Gly Asp Gly Asp Ser Phe 
    770                 775                 780                 


Tyr Ser Asp Ile Pro Pro Gly Val Ser Thr Asn Ser Ala Ser Ser Ser 
785                 790                 795                 800 


Lys Lys Arg Ser Asn Gly Leu Ser His Ser Trp Ser Glu Arg Ile Pro 
                805                 810                 815     


Asp Thr Lys His Ile Ser Asp Ile Cys Glu Asn Gly Arg Pro Arg Ser 
            820                 825                 830         


Asn Ser Trp Gln Gly Asn Leu Gly Gly Asn Lys Lys Lys Ile Arg Gly 
        835                 840                 845             


Lys Arg Phe Arg Pro Arg Ser Asn Ser Thr Glu Thr Leu Ser Pro Ala 
    850                 855                 860                 


Lys Ser Pro Ser Ser Ser Thr Gly Ser Ile Ala Ser Ser Arg Lys Tyr 
865                 870                 875                 880 


Pro Tyr Pro Met Pro Pro Leu Pro Asp Glu Asp Lys Lys Val Asn Arg 
                885                 890                 895     


Gln Ser Ala Arg Leu Trp Glu Thr Ser Ile 
            900                 905     


<210>  4822
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  4822

Met Gly Pro Gly Pro Pro Ala Ala Gly Ala Ala Pro Ser Pro Arg Pro 
1               5                   10                  15      


Leu Ser Leu Val Ala Arg Leu Ser Tyr Ala Val Gly His Phe Leu Asn 
            20                  25                  30          


Asp Leu Cys Ala Ser Met Trp Phe Thr Tyr Leu Leu Leu Tyr Leu His 
        35                  40                  45              


Ser Val Arg Ala Tyr Ser Ser Arg Gly Ala Gly Leu Leu Leu Leu Leu 
    50                  55                  60                  


Gly Gln Val Ala Asp Gly Leu Cys Thr Pro Leu Val Gly Tyr Glu Ala 
65                  70                  75                  80  


Asp Arg Ala Ala Ser Cys Cys Ala Arg Tyr Gly Thr Val Cys Val Leu 
                85                  90                  95      


Leu Ser Phe Pro Phe Ile Phe Ser Pro Cys Leu Gly Cys Gly Ala Ala 
            100                 105                 110         


Thr Pro Glu Trp Ala Ala Leu Leu Tyr Tyr Gly Pro Phe Ile Val Ile 
        115                 120                 125             


Phe Gln Phe Gly Trp Ala Ser Thr Gln Ile Ser His Leu Ser Leu Ile 
    130                 135                 140                 


Pro Glu Leu Val Thr Asn Asp His Glu Lys Val Glu Leu Thr Ala Leu 
145                 150                 155                 160 


Arg Tyr Ala Phe Thr Val Val Ala Asn Ile Thr Val Tyr Gly Ala Ala 
                165                 170                 175     


Trp Leu Leu Leu His Leu Gln Gly Ser Ser Arg Val Glu Pro Thr Gln 
            180                 185                 190         


Asp Ile Ser Ile Ser Asp Gln Leu Gly Gly Gln Asp Val Pro Val Phe 
        195                 200                 205             


Arg Asn Leu Ser Leu Leu Val Val Gly Val Gly Ala Val Phe Ser Leu 
    210                 215                 220                 


Leu Phe His Leu Gly Thr Arg Glu Arg Arg Arg Pro His Ala Glu Glu 
225                 230                 235                 240 


Pro Gly Glu His Thr Pro Leu Leu Ala Pro Ala Thr Ala Gln Pro Leu 
                245                 250                 255     


Leu Leu Trp Lys His Trp Leu Arg Glu Pro Ala Phe Tyr Gln Val Gly 
            260                 265                 270         


Ile Leu Tyr Met Thr Thr Arg Leu Ile Val Asn Leu Ser Gln Thr Tyr 
        275                 280                 285             


Met Ala Met Tyr Leu Thr Tyr Ser Leu His Leu Pro Lys Lys Phe Ile 
    290                 295                 300                 


Ala Thr Ile Pro Leu Val Met Tyr Leu Ser Gly Phe Leu Ser Ser Phe 
305                 310                 315                 320 


Leu Met Lys Pro Ile Asn Lys Cys Ile Gly Arg Asn Met Thr Tyr Phe 
                325                 330                 335     


Ser Gly Leu Leu Val Ile Leu Ala Phe Ala Ala Trp Val Ala Leu Ala 
            340                 345                 350         


Glu Gly Leu Gly Val Ala Val Tyr Ala Ala Ala Val Leu Leu Gly Ala 
        355                 360                 365             


Gly Cys Ala Thr Ile Leu Val Thr Ser Leu Ala Met Thr Ala Asp Leu 
    370                 375                 380                 


Ile Gly Pro His Thr Asn Ser Gly Ala Phe Val Tyr Gly Ser Met Ser 
385                 390                 395                 400 


Phe Leu Asp Lys Val Ala Asn Gly Leu Ala Val Met Ala Ile Gln Ser 
                405                 410                 415     


Leu His Pro Cys Pro Ser Glu Leu Cys Cys Arg Ala Cys Val Ser Phe 
            420                 425                 430         


Tyr His Trp Ala Met Val Ala Val Thr Gly Gly Val Gly Val Ala Ala 
        435                 440                 445             


Ala Leu Cys Leu Cys Ser Leu Leu Leu Trp Pro Thr Arg Leu Arg Arg 
    450                 455                 460                 


Trp Asp Arg Asp Ala Arg Pro 
465                 470     


<210>  4823
<211>  847
<212>  PRT
<213>  Homo sapiens

<400>  4823

Met Ala Gly Cys Arg Gly Ser Leu Cys Cys Cys Cys Arg Trp Cys Cys 
1               5                   10                  15      


Cys Cys Gly Glu Arg Glu Thr Arg Thr Pro Glu Glu Leu Thr Ile Leu 
            20                  25                  30          


Gly Glu Thr Gln Glu Glu Glu Asp Glu Ile Leu Pro Arg Lys Asp Tyr 
        35                  40                  45              


Glu Lys Gly Arg Arg Tyr Glu Ala Val Lys Trp Met Val Val Phe Ala 
    50                  55                  60                  


Ile Gly Val Cys Thr Gly Leu Val Gly Leu Phe Val Asp Phe Phe Val 
65                  70                  75                  80  


Arg Leu Phe Thr Gln Leu Lys Phe Gly Val Val Gln Thr Ser Val Glu 
                85                  90                  95      


Glu Cys Ser Gln Lys Gly Cys Leu Ala Leu Ser Leu Leu Glu Leu Leu 
            100                 105                 110         


Gly Phe Asn Leu Thr Phe Val Phe Leu Ala Ser Leu Leu Val Leu Ile 
        115                 120                 125             


Glu Pro Val Ala Ala Gly Ser Gly Ile Pro Glu Val Lys Cys Tyr Leu 
    130                 135                 140                 


Asn Gly Val Lys Val Pro Gly Ile Val Arg Leu Arg Thr Leu Leu Cys 
145                 150                 155                 160 


Lys Val Leu Gly Val Leu Phe Ser Val Ala Gly Gly Leu Phe Val Gly 
                165                 170                 175     


Lys Glu Gly Pro Met Ile His Ser Gly Ser Val Val Gly Ala Gly Leu 
            180                 185                 190         


Pro Gln Phe Gln Ser Ile Ser Leu Arg Lys Ile Gln Phe Asn Phe Pro 
        195                 200                 205             


Tyr Phe Arg Ser Asp Arg Asp Lys Arg Asp Phe Val Ser Ala Gly Ala 
    210                 215                 220                 


Ala Ala Gly Val Ala Ala Ala Phe Gly Ala Pro Ile Gly Gly Thr Leu 
225                 230                 235                 240 


Phe Ser Leu Glu Glu Gly Ser Ser Phe Trp Asn Gln Gly Leu Thr Trp 
                245                 250                 255     


Lys Val Leu Phe Cys Ser Met Ser Ala Thr Phe Thr Leu Asn Phe Phe 
            260                 265                 270         


Arg Ser Gly Ile Gln Phe Gly Ser Trp Gly Ser Phe Gln Leu Pro Gly 
        275                 280                 285             


Leu Leu Asn Phe Gly Glu Phe Lys Cys Ser Asp Ser Asp Lys Lys Cys 
    290                 295                 300                 


His Leu Trp Thr Ala Met Asp Leu Gly Phe Phe Val Val Met Gly Val 
305                 310                 315                 320 


Ile Gly Gly Leu Leu Gly Ala Thr Phe Asn Cys Leu Asn Lys Arg Leu 
                325                 330                 335     


Ala Lys Tyr Arg Met Arg Asn Val His Pro Lys Pro Lys Leu Val Arg 
            340                 345                 350         


Val Leu Glu Ser Leu Leu Val Ser Leu Val Thr Thr Val Val Val Phe 
        355                 360                 365             


Val Ala Ser Met Val Leu Gly Glu Cys Arg Gln Met Ser Ser Ser Ser 
    370                 375                 380                 


Gln Ile Gly Asn Asp Ser Phe Gln Leu Gln Val Thr Glu Asp Val Asn 
385                 390                 395                 400 


Ser Ser Ile Lys Thr Phe Phe Cys Pro Asn Asp Thr Tyr Asn Asp Met 
                405                 410                 415     


Ala Thr Leu Phe Phe Asn Pro Gln Glu Ser Ala Ile Leu Gln Leu Phe 
            420                 425                 430         


His Gln Asp Gly Thr Phe Ser Pro Val Thr Leu Ala Leu Phe Phe Val 
        435                 440                 445             


Leu Tyr Phe Leu Leu Ala Cys Trp Thr Tyr Gly Ile Ser Val Pro Ser 
    450                 455                 460                 


Gly Leu Phe Val Pro Ser Leu Leu Cys Gly Ala Ala Phe Gly Arg Leu 
465                 470                 475                 480 


Val Ala Asn Val Leu Lys Ser Tyr Ile Gly Leu Gly His Ile Tyr Ser 
                485                 490                 495     


Gly Thr Phe Ala Leu Ile Gly Ala Ala Ala Phe Leu Gly Gly Val Val 
            500                 505                 510         


Arg Met Thr Ile Ser Leu Thr Val Ile Leu Ile Glu Ser Thr Asn Glu 
        515                 520                 525             


Ile Thr Tyr Gly Leu Pro Ile Met Val Thr Leu Met Val Ala Lys Trp 
    530                 535                 540                 


Thr Gly Asp Phe Phe Asn Lys Gly Ile Tyr Asp Ile His Val Gly Leu 
545                 550                 555                 560 


Arg Gly Val Pro Leu Leu Glu Trp Glu Thr Glu Val Glu Met Asp Lys 
                565                 570                 575     


Leu Arg Ala Ser Asp Ile Met Glu Pro Asn Leu Thr Tyr Val Tyr Pro 
            580                 585                 590         


His Thr Arg Ile Gln Ser Leu Val Ser Ile Leu Arg Thr Thr Val His 
        595                 600                 605             


His Ala Phe Pro Val Val Thr Glu Asn Arg Gly Asn Glu Lys Glu Phe 
    610                 615                 620                 


Met Lys Gly Asn Gln Leu Ile Ser Asn Asn Ile Lys Phe Lys Lys Ser 
625                 630                 635                 640 


Ser Ile Leu Thr Arg Ala Gly Glu Gln Arg Lys Arg Ser Gln Ser Met 
                645                 650                 655     


Lys Ser Tyr Pro Ser Ser Glu Leu Arg Asn Met Cys Asp Glu His Ile 
            660                 665                 670         


Ala Ser Glu Glu Pro Ala Glu Lys Glu Asp Leu Leu Gln Gln Met Leu 
        675                 680                 685             


Glu Arg Arg Tyr Thr Pro Tyr Pro Asn Leu Tyr Pro Asp Gln Ser Pro 
    690                 695                 700                 


Ser Glu Asp Trp Thr Met Glu Glu Arg Phe Arg Pro Leu Thr Phe His 
705                 710                 715                 720 


Gly Leu Ile Leu Arg Ser Gln Leu Val Thr Leu Leu Val Arg Gly Val 
                725                 730                 735     


Cys Tyr Ser Glu Ser Gln Ser Ser Ala Ser Gln Pro Arg Leu Ser Tyr 
            740                 745                 750         


Ala Glu Met Ala Glu Asp Tyr Pro Arg Tyr Pro Asp Ile His Asp Leu 
        755                 760                 765             


Asp Leu Thr Leu Leu Asn Pro Arg Met Ile Val Asp Val Thr Pro Tyr 
    770                 775                 780                 


Met Asn Pro Ser Pro Phe Thr Val Ser Pro Asn Thr His Val Ser Gln 
785                 790                 795                 800 


Val Phe Asn Leu Phe Arg Thr Met Gly Leu Arg His Leu Pro Val Val 
                805                 810                 815     


Asn Ala Val Gly Glu Ile Val Gly Ile Ile Thr Arg His Asn Leu Thr 
            820                 825                 830         


Tyr Glu Phe Leu Gln Ala Arg Leu Arg Gln His Tyr Gln Thr Ile 
        835                 840                 845         


<210>  4824
<211>  847
<212>  PRT
<213>  Homo sapiens

<400>  4824

Met Ala Gly Cys Arg Gly Ser Leu Cys Cys Cys Cys Arg Trp Cys Cys 
1               5                   10                  15      


Cys Cys Gly Glu Arg Glu Thr Arg Thr Pro Glu Glu Leu Thr Ile Leu 
            20                  25                  30          


Gly Glu Thr Gln Glu Glu Glu Asp Glu Ile Leu Pro Arg Lys Asp Tyr 
        35                  40                  45              


Glu Lys Gly Arg Arg Tyr Glu Ala Val Lys Trp Met Val Val Phe Ala 
    50                  55                  60                  


Ile Gly Val Cys Thr Gly Leu Val Gly Leu Phe Val Asp Phe Phe Val 
65                  70                  75                  80  


Arg Leu Phe Thr Gln Leu Lys Phe Gly Val Val Gln Thr Ser Val Glu 
                85                  90                  95      


Glu Cys Ser Gln Lys Gly Cys Leu Ala Leu Ser Leu Leu Glu Leu Leu 
            100                 105                 110         


Gly Phe Asn Leu Thr Phe Val Phe Leu Ala Ser Leu Leu Val Leu Ile 
        115                 120                 125             


Glu Pro Val Ala Ala Gly Ser Gly Ile Pro Glu Val Lys Cys Tyr Leu 
    130                 135                 140                 


Asn Gly Val Lys Val Pro Gly Ile Val Arg Leu Arg Thr Leu Leu Cys 
145                 150                 155                 160 


Lys Val Leu Gly Val Leu Phe Ser Val Ala Gly Gly Leu Phe Val Gly 
                165                 170                 175     


Lys Glu Gly Pro Met Ile His Ser Gly Ser Val Val Gly Ala Gly Leu 
            180                 185                 190         


Pro Gln Phe Gln Ser Ile Ser Leu Arg Lys Ile Gln Phe Asn Phe Pro 
        195                 200                 205             


Tyr Phe Arg Ser Asp Arg Asp Lys Arg Asp Phe Val Ser Ala Gly Ala 
    210                 215                 220                 


Ala Ala Gly Val Ala Ala Ala Phe Gly Ala Pro Ile Gly Gly Thr Leu 
225                 230                 235                 240 


Phe Ser Leu Glu Glu Gly Ser Ser Phe Trp Asn Gln Gly Leu Thr Trp 
                245                 250                 255     


Lys Val Leu Phe Cys Ser Met Ser Ala Thr Phe Thr Leu Asn Phe Phe 
            260                 265                 270         


Arg Ser Gly Ile Gln Phe Gly Ser Trp Gly Ser Phe Gln Leu Pro Gly 
        275                 280                 285             


Leu Leu Asn Phe Gly Glu Phe Lys Cys Ser Asp Ser Asp Lys Lys Cys 
    290                 295                 300                 


His Leu Trp Thr Ala Met Asp Leu Gly Phe Phe Val Val Met Gly Val 
305                 310                 315                 320 


Ile Gly Gly Leu Leu Gly Ala Thr Phe Asn Cys Leu Asn Lys Arg Leu 
                325                 330                 335     


Ala Lys Tyr Arg Met Arg Asn Val His Pro Lys Pro Lys Leu Val Arg 
            340                 345                 350         


Val Leu Glu Ser Leu Leu Val Ser Leu Val Thr Thr Val Val Val Phe 
        355                 360                 365             


Val Ala Ser Met Val Leu Gly Glu Cys Arg Gln Met Ser Ser Ser Ser 
    370                 375                 380                 


Gln Ile Gly Asn Asp Ser Phe Gln Leu Gln Val Thr Glu Asp Val Asn 
385                 390                 395                 400 


Ser Ser Ile Lys Thr Phe Phe Cys Pro Asn Asp Thr Tyr Asn Asp Met 
                405                 410                 415     


Ala Thr Leu Phe Phe Asn Pro Gln Glu Ser Ala Ile Leu Gln Leu Phe 
            420                 425                 430         


His Gln Asp Gly Thr Phe Ser Pro Val Thr Leu Ala Leu Phe Phe Val 
        435                 440                 445             


Leu Tyr Phe Leu Leu Ala Cys Trp Thr Tyr Gly Ile Ser Val Pro Ser 
    450                 455                 460                 


Gly Leu Phe Val Pro Ser Leu Leu Cys Gly Ala Ala Phe Gly Arg Leu 
465                 470                 475                 480 


Val Ala Asn Val Leu Lys Ser Tyr Ile Gly Leu Gly His Ile Tyr Ser 
                485                 490                 495     


Gly Thr Phe Ala Leu Ile Gly Ala Ala Ala Phe Leu Gly Gly Val Val 
            500                 505                 510         


Arg Met Thr Ile Ser Leu Thr Val Ile Leu Ile Glu Ser Thr Asn Glu 
        515                 520                 525             


Ile Thr Tyr Gly Leu Pro Ile Met Val Thr Leu Met Val Ala Lys Trp 
    530                 535                 540                 


Thr Gly Asp Phe Phe Asn Lys Gly Ile Tyr Asp Ile His Val Gly Leu 
545                 550                 555                 560 


Arg Gly Val Pro Leu Leu Glu Trp Glu Thr Glu Val Glu Met Asp Lys 
                565                 570                 575     


Leu Arg Ala Ser Asp Ile Met Glu Pro Asn Leu Thr Tyr Val Tyr Pro 
            580                 585                 590         


His Thr Arg Ile Gln Ser Leu Val Ser Ile Leu Arg Thr Thr Val His 
        595                 600                 605             


His Ala Phe Pro Val Val Thr Glu Asn Arg Gly Asn Glu Lys Glu Phe 
    610                 615                 620                 


Met Lys Gly Asn Gln Leu Ile Ser Asn Asn Ile Lys Phe Lys Lys Ser 
625                 630                 635                 640 


Ser Ile Leu Thr Arg Ala Gly Glu Gln Arg Lys Arg Ser Gln Ser Met 
                645                 650                 655     


Lys Ser Tyr Pro Ser Ser Glu Leu Arg Asn Met Cys Asp Glu His Ile 
            660                 665                 670         


Ala Ser Glu Glu Pro Ala Glu Lys Glu Asp Leu Leu Gln Gln Met Leu 
        675                 680                 685             


Glu Arg Arg Tyr Thr Pro Tyr Pro Asn Leu Tyr Pro Asp Gln Ser Pro 
    690                 695                 700                 


Ser Glu Asp Trp Thr Met Glu Glu Arg Phe Arg Pro Leu Thr Phe His 
705                 710                 715                 720 


Gly Leu Ile Leu Arg Ser Gln Leu Val Thr Leu Leu Val Arg Gly Val 
                725                 730                 735     


Cys Tyr Ser Glu Ser Gln Ser Ser Ala Ser Gln Pro Arg Leu Ser Tyr 
            740                 745                 750         


Ala Glu Met Ala Glu Asp Tyr Pro Arg Tyr Pro Asp Ile His Asp Leu 
        755                 760                 765             


Asp Leu Thr Leu Leu Asn Pro Arg Met Ile Val Asp Val Thr Pro Tyr 
    770                 775                 780                 


Met Asn Pro Ser Pro Phe Thr Val Ser Pro Asn Thr His Val Ser Gln 
785                 790                 795                 800 


Val Phe Asn Leu Phe Arg Thr Met Gly Leu Arg His Leu Pro Val Val 
                805                 810                 815     


Asn Ala Val Gly Glu Ile Val Gly Ile Ile Thr Arg His Asn Leu Thr 
            820                 825                 830         


Tyr Glu Phe Leu Gln Ala Arg Leu Arg Gln His Tyr Gln Thr Ile 
        835                 840                 845         


<210>  4825
<211>  847
<212>  PRT
<213>  Homo sapiens

<400>  4825

Met Ala Gly Cys Arg Gly Ser Leu Cys Cys Cys Cys Arg Trp Cys Cys 
1               5                   10                  15      


Cys Cys Gly Glu Arg Glu Thr Arg Thr Pro Glu Glu Leu Thr Ile Leu 
            20                  25                  30          


Gly Glu Thr Gln Glu Glu Glu Asp Glu Ile Leu Pro Arg Lys Asp Tyr 
        35                  40                  45              


Glu Lys Gly Arg Arg Tyr Glu Ala Val Lys Trp Met Val Val Phe Ala 
    50                  55                  60                  


Ile Gly Val Cys Thr Gly Leu Val Gly Leu Phe Val Asp Phe Phe Val 
65                  70                  75                  80  


Arg Leu Phe Thr Gln Leu Lys Phe Gly Val Val Gln Thr Ser Val Glu 
                85                  90                  95      


Glu Cys Ser Gln Lys Gly Cys Leu Ala Leu Ser Leu Leu Glu Leu Leu 
            100                 105                 110         


Gly Phe Asn Leu Thr Phe Val Phe Leu Ala Ser Leu Leu Val Leu Ile 
        115                 120                 125             


Glu Pro Val Ala Ala Gly Ser Gly Ile Pro Glu Val Lys Cys Tyr Leu 
    130                 135                 140                 


Asn Gly Val Lys Val Pro Gly Ile Val Arg Leu Arg Thr Leu Leu Cys 
145                 150                 155                 160 


Lys Val Leu Gly Val Leu Phe Ser Val Ala Gly Gly Leu Phe Val Gly 
                165                 170                 175     


Lys Glu Gly Pro Met Ile His Ser Gly Ser Val Val Gly Ala Gly Leu 
            180                 185                 190         


Pro Gln Phe Gln Ser Ile Ser Leu Arg Lys Ile Gln Phe Asn Phe Pro 
        195                 200                 205             


Tyr Phe Arg Ser Asp Arg Asp Lys Arg Asp Phe Val Ser Ala Gly Ala 
    210                 215                 220                 


Ala Ala Gly Val Ala Ala Ala Phe Gly Ala Pro Ile Gly Gly Thr Leu 
225                 230                 235                 240 


Phe Ser Leu Glu Glu Gly Ser Ser Phe Trp Asn Gln Gly Leu Thr Trp 
                245                 250                 255     


Lys Val Leu Phe Cys Ser Met Ser Ala Thr Phe Thr Leu Asn Phe Phe 
            260                 265                 270         


Arg Ser Gly Ile Gln Phe Gly Ser Trp Gly Ser Phe Gln Leu Pro Gly 
        275                 280                 285             


Leu Leu Asn Phe Gly Glu Phe Lys Cys Ser Asp Ser Asp Lys Lys Cys 
    290                 295                 300                 


His Leu Trp Thr Ala Met Asp Leu Gly Phe Phe Val Val Met Gly Val 
305                 310                 315                 320 


Ile Gly Gly Leu Leu Gly Ala Thr Phe Asn Cys Leu Asn Lys Arg Leu 
                325                 330                 335     


Ala Lys Tyr Arg Met Arg Asn Val His Pro Lys Pro Lys Leu Val Arg 
            340                 345                 350         


Val Leu Glu Ser Leu Leu Val Ser Leu Val Thr Thr Val Val Val Phe 
        355                 360                 365             


Val Ala Ser Met Val Leu Gly Glu Cys Arg Gln Met Ser Ser Ser Ser 
    370                 375                 380                 


Gln Ile Gly Asn Asp Ser Phe Gln Leu Gln Val Thr Glu Asp Val Asn 
385                 390                 395                 400 


Ser Ser Ile Lys Thr Phe Phe Cys Pro Asn Asp Thr Tyr Asn Asp Met 
                405                 410                 415     


Ala Thr Leu Phe Phe Asn Pro Gln Glu Ser Ala Ile Leu Gln Leu Phe 
            420                 425                 430         


His Gln Asp Gly Thr Phe Ser Pro Val Thr Leu Ala Leu Phe Phe Val 
        435                 440                 445             


Leu Tyr Phe Leu Leu Ala Cys Trp Thr Tyr Gly Ile Ser Val Pro Ser 
    450                 455                 460                 


Gly Leu Phe Val Pro Ser Leu Leu Cys Gly Ala Ala Phe Gly Arg Leu 
465                 470                 475                 480 


Val Ala Asn Val Leu Lys Ser Tyr Ile Gly Leu Gly His Ile Tyr Ser 
                485                 490                 495     


Gly Thr Phe Ala Leu Ile Gly Ala Ala Ala Phe Leu Gly Gly Val Val 
            500                 505                 510         


Arg Met Thr Ile Ser Leu Thr Val Ile Leu Ile Glu Ser Thr Asn Glu 
        515                 520                 525             


Ile Thr Tyr Gly Leu Pro Ile Met Val Thr Leu Met Val Ala Lys Trp 
    530                 535                 540                 


Thr Gly Asp Phe Phe Asn Lys Gly Ile Tyr Asp Ile His Val Gly Leu 
545                 550                 555                 560 


Arg Gly Val Pro Leu Leu Glu Trp Glu Thr Glu Val Glu Met Asp Lys 
                565                 570                 575     


Leu Arg Ala Ser Asp Ile Met Glu Pro Asn Leu Thr Tyr Val Tyr Pro 
            580                 585                 590         


His Thr Arg Ile Gln Ser Leu Val Ser Ile Leu Arg Thr Thr Val His 
        595                 600                 605             


His Ala Phe Pro Val Val Thr Glu Asn Arg Gly Asn Glu Lys Glu Phe 
    610                 615                 620                 


Met Lys Gly Asn Gln Leu Ile Ser Asn Asn Ile Lys Phe Lys Lys Ser 
625                 630                 635                 640 


Ser Ile Leu Thr Arg Ala Gly Glu Gln Arg Lys Arg Ser Gln Ser Met 
                645                 650                 655     


Lys Ser Tyr Pro Ser Ser Glu Leu Arg Asn Met Cys Asp Glu His Ile 
            660                 665                 670         


Ala Ser Glu Glu Pro Ala Glu Lys Glu Asp Leu Leu Gln Gln Met Leu 
        675                 680                 685             


Glu Arg Arg Tyr Thr Pro Tyr Pro Asn Leu Tyr Pro Asp Gln Ser Pro 
    690                 695                 700                 


Ser Glu Asp Trp Thr Met Glu Glu Arg Phe Arg Pro Leu Thr Phe His 
705                 710                 715                 720 


Gly Leu Ile Leu Arg Ser Gln Leu Val Thr Leu Leu Val Arg Gly Val 
                725                 730                 735     


Cys Tyr Ser Glu Ser Gln Ser Ser Ala Ser Gln Pro Arg Leu Ser Tyr 
            740                 745                 750         


Ala Glu Met Ala Glu Asp Tyr Pro Arg Tyr Pro Asp Ile His Asp Leu 
        755                 760                 765             


Asp Leu Thr Leu Leu Asn Pro Arg Met Ile Val Asp Val Thr Pro Tyr 
    770                 775                 780                 


Met Asn Pro Ser Pro Phe Thr Val Ser Pro Asn Thr His Val Ser Gln 
785                 790                 795                 800 


Val Phe Asn Leu Phe Arg Thr Met Gly Leu Arg His Leu Pro Val Val 
                805                 810                 815     


Asn Ala Val Gly Glu Ile Val Gly Ile Ile Thr Arg His Asn Leu Thr 
            820                 825                 830         


Tyr Glu Phe Leu Gln Ala Arg Leu Arg Gln His Tyr Gln Thr Ile 
        835                 840                 845         


<210>  4826
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  4826

Met Gly Gly Val Gly Glu Pro Gly Pro Arg Glu Gly Pro Ala Gln Pro 
1               5                   10                  15      


Gly Ala Pro Leu Pro Thr Phe Cys Trp Glu Gln Ile Arg Ala His Asp 
            20                  25                  30          


Gln Pro Gly Asp Lys Trp Leu Val Ile Glu Arg Arg Val Tyr Asp Ile 
        35                  40                  45              


Ser Arg Trp Ala Gln Arg His Pro Gly Gly Ser Arg Leu Ile Gly His 
    50                  55                  60                  


His Gly Ala Glu Asp Ala Thr Asp Ala Phe Arg Ala Phe His Gln Asp 
65                  70                  75                  80  


Leu Asn Phe Val Arg Lys Phe Leu Gln Pro Leu Leu Ile Gly Glu Leu 
                85                  90                  95      


Ala Pro Glu Glu Pro Ser Gln Asp Gly Pro Leu Asn Ala Gln Leu Val 
            100                 105                 110         


Glu Asp Phe Arg Ala Leu His Gln Ala Ala Glu Asp Met Lys Leu Phe 
        115                 120                 125             


Asp Ala Ser Pro Thr Phe Phe Ala Phe Leu Leu Gly His Ile Leu Ala 
    130                 135                 140                 


Met Glu Val Leu Ala Trp Leu Leu Ile Tyr Leu Leu Gly Pro Gly Trp 
145                 150                 155                 160 


Val Pro Ser Ala Leu Ala Ala Phe Ile Leu Ala Ile Ser Gln Ala Gln 
                165                 170                 175     


Ser Trp Cys Leu Gln His Asp Leu Gly His Ala Ser Ile Phe Lys Lys 
            180                 185                 190         


Ser Trp Trp Asn His Val Ala Gln Lys Phe Val Met Gly Gln Leu Lys 
        195                 200                 205             


Gly Phe Ser Ala His Trp Trp Asn Phe Arg His Phe Gln His His Ala 
    210                 215                 220                 


Lys Pro Asn Ile Phe His Lys Asp Pro Asp Val Thr Val Ala Pro Val 
225                 230                 235                 240 


Phe Leu Leu Gly Glu Ser Ser Val Glu Tyr Gly Lys Lys Lys Arg Arg 
                245                 250                 255     


Tyr Leu Pro Tyr Asn Gln Gln His Leu Tyr Phe Phe Leu Ile Gly Pro 
            260                 265                 270         


Pro Leu Leu Thr Leu Val Asn Phe Glu Val Glu Asn Leu Ala Tyr Met 
        275                 280                 285             


Leu Val Cys Met Gln Trp Ala Asp Leu Leu Trp Ala Ala Ser Phe Tyr 
    290                 295                 300                 


Ala Arg Phe Phe Leu Ser Tyr Leu Pro Phe Tyr Gly Val Pro Gly Val 
305                 310                 315                 320 


Leu Leu Phe Phe Val Ala Val Arg Val Leu Glu Ser His Trp Phe Val 
                325                 330                 335     


Trp Ile Thr Gln Met Asn His Ile Pro Lys Glu Ile Gly His Glu Lys 
            340                 345                 350         


His Arg Asp Trp Val Ser Ser Gln Leu Ala Ala Thr Cys Asn Val Glu 
        355                 360                 365             


Pro Ser Leu Phe Thr Asn Trp Phe Ser Gly His Leu Asn Phe Gln Ile 
    370                 375                 380                 


Glu His His Leu Phe Pro Arg Met Pro Arg His Asn Tyr Ser Arg Val 
385                 390                 395                 400 


Ala Pro Leu Val Lys Ser Leu Cys Ala Lys His Gly Leu Ser Tyr Glu 
                405                 410                 415     


Val Lys Pro Phe Leu Thr Ala Leu Val Asp Ile Val Arg Ser Leu Lys 
            420                 425                 430         


Lys Ser Gly Asp Ile Trp Leu Asp Ala Tyr Leu His Gln 
        435                 440                 445 


<210>  4827
<211>  540
<212>  PRT
<213>  Homo sapiens

<400>  4827

Met Leu Gln Gly Leu Leu Pro Val Ser Leu Leu Leu Ser Val Ala Val 
1               5                   10                  15      


Ser Ala Ile Lys Glu Leu Pro Gly Val Lys Lys Tyr Glu Val Val Tyr 
            20                  25                  30          


Pro Ile Arg Leu His Pro Leu His Lys Arg Glu Ala Lys Glu Pro Glu 
        35                  40                  45              


Gln Gln Glu Gln Phe Glu Thr Glu Leu Lys Tyr Lys Met Thr Ile Asn 
    50                  55                  60                  


Gly Lys Ile Ala Val Leu Tyr Leu Lys Lys Asn Lys Asn Leu Leu Ala 
65                  70                  75                  80  


Pro Gly Tyr Thr Glu Thr Tyr Tyr Asn Ser Thr Gly Lys Glu Ile Thr 
                85                  90                  95      


Thr Ser Pro Gln Ile Met Asp Asp Cys Tyr Tyr Gln Gly His Ile Leu 
            100                 105                 110         


Asn Glu Lys Val Ser Asp Ala Ser Ile Ser Thr Cys Arg Gly Leu Arg 
        115                 120                 125             


Gly Tyr Phe Ser Gln Gly Asp Gln Arg Tyr Phe Ile Glu Pro Leu Ser 
    130                 135                 140                 


Pro Ile His Arg Asp Gly Gln Glu His Ala Leu Phe Lys Tyr Asn Pro 
145                 150                 155                 160 


Asp Glu Lys Asn Tyr Asp Ser Thr Cys Gly Met Asp Gly Val Leu Trp 
                165                 170                 175     


Ala His Asp Leu Gln Gln Asn Ile Ala Leu Pro Ala Thr Lys Leu Val 
            180                 185                 190         


Lys Leu Lys Asp Arg Lys Val Gln Glu His Glu Lys Tyr Ile Glu Tyr 
        195                 200                 205             


Tyr Leu Val Leu Asp Asn Gly Glu Phe Lys Arg Tyr Asn Glu Asn Gln 
    210                 215                 220                 


Asp Glu Ile Arg Lys Arg Val Phe Glu Met Ala Asn Tyr Val Asn Met 
225                 230                 235                 240 


Leu Tyr Lys Lys Leu Asn Thr His Val Ala Leu Val Gly Met Glu Ile 
                245                 250                 255     


Trp Thr Asp Lys Asp Lys Ile Lys Ile Thr Pro Asn Ala Ser Phe Thr 
            260                 265                 270         


Leu Glu Asn Phe Ser Lys Trp Arg Gly Ser Val Leu Ser Arg Arg Lys 
        275                 280                 285             


Arg His Asp Ile Ala Gln Leu Ile Thr Ala Thr Glu Leu Ala Gly Thr 
    290                 295                 300                 


Thr Val Gly Leu Ala Phe Met Ser Thr Met Cys Ser Pro Tyr Ser Val 
305                 310                 315                 320 


Gly Val Val Gln Asp His Ser Asp Asn Leu Leu Arg Val Ala Gly Thr 
                325                 330                 335     


Met Ala His Glu Met Gly His Asn Phe Gly Met Phe His Asp Asp Tyr 
            340                 345                 350         


Ser Cys Lys Cys Pro Ser Thr Ile Cys Val Met Asp Lys Ala Leu Ser 
        355                 360                 365             


Phe Tyr Ile Pro Thr Asp Phe Ser Ser Cys Ser Arg Leu Ser Tyr Asp 
    370                 375                 380                 


Lys Phe Phe Glu Asp Lys Leu Ser Asn Cys Leu Phe Asn Ala Pro Leu 
385                 390                 395                 400 


Pro Thr Asp Ile Ile Ser Thr Pro Ile Cys Gly Asn Gln Leu Val Glu 
                405                 410                 415     


Met Gly Glu Asp Cys Asp Cys Gly Thr Ser Glu Glu Cys Thr Asn Ile 
            420                 425                 430         


Cys Cys Asp Ala Lys Thr Cys Lys Ile Lys Ala Thr Phe Gln Cys Ala 
        435                 440                 445             


Leu Gly Glu Cys Cys Glu Lys Cys Gln Phe Lys Lys Ala Gly Met Val 
    450                 455                 460                 


Cys Arg Pro Ala Lys Asp Glu Cys Asp Leu Pro Glu Met Cys Asn Gly 
465                 470                 475                 480 


Lys Ser Gly Asn Cys Pro Asp Asp Arg Phe Gln Val Asn Gly Phe Pro 
                485                 490                 495     


Cys His His Gly Lys Gly His Cys Leu Met Gly Thr Cys Pro Thr Leu 
            500                 505                 510         


Gln Glu Gln Cys Thr Glu Leu Trp Gly Pro Gly Arg Arg Thr Asn Pro 
        515                 520                 525             


Phe Pro Cys Ala Cys Ala Lys Glu Asn His Phe Arg 
    530                 535                 540 


<210>  4828
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  4828

Met Asp Cys Gln Glu Asn Glu Tyr Trp Asp Gln Trp Gly Arg Cys Val 
1               5                   10                  15      


Thr Cys Gln Arg Cys Gly Pro Gly Gln Glu Leu Ser Lys Asp Cys Gly 
            20                  25                  30          


Tyr Gly Glu Gly Gly Asp Ala Tyr Cys Thr Ala Cys Pro Pro Arg Arg 
        35                  40                  45              


Tyr Lys Ser Ser Trp Gly His His Arg Cys Gln Ser Cys Ile Thr Cys 
    50                  55                  60                  


Ala Val Ile Asn Arg Val Gln Lys Val Asn Cys Thr Ala Thr Ser Asn 
65                  70                  75                  80  


Ala Val Cys Gly Asp Cys Leu Pro Arg Phe Tyr Arg Lys Thr Arg Ile 
                85                  90                  95      


Gly Gly Leu Gln Asp Gln Glu Cys Ile Pro Cys Thr Lys Gln Thr Pro 
            100                 105                 110         


Thr Ser Glu Val Gln Cys Ala Phe Gln Leu Ser Leu Val Glu Ala Asp 
        115                 120                 125             


Ala Pro Thr Val Pro Pro Gln Glu Ala Thr Leu Val Ala Leu Val Ser 
    130                 135                 140                 


Ser Leu Leu Val Val Phe Thr Leu Ala Phe Leu Gly Leu Phe Phe Leu 
145                 150                 155                 160 


Tyr Cys Lys Gln Phe Phe Asn Arg His Cys Gln Arg Gly Gly Leu Leu 
                165                 170                 175     


Gln Phe Glu Ala Asp Lys Thr Ala Lys Glu Glu Ser Leu Phe Pro Val 
            180                 185                 190         


Pro Pro Ser Lys Glu Thr Ser Ala Glu Ser Gln Val Ser Glu Asn Ile 
        195                 200                 205             


Phe Gln Thr Gln Pro Leu Asn Pro Ile Leu Glu Asp Asp Cys Ser Ser 
    210                 215                 220                 


Thr Ser Gly Phe Pro Thr Gln Glu Ser Phe Thr Met Ala Ser Cys Thr 
225                 230                 235                 240 


Ser Glu Ser His Ser His Trp Val His Ser Pro Ile Glu Cys Thr Glu 
                245                 250                 255     


Leu Asp Leu Gln Lys Phe Ser Ser Ser Ala Ser Tyr Thr Gly Ala Glu 
            260                 265                 270         


Thr Leu Gly Gly Asn Thr Val Glu Ser Thr Gly Asp Arg Leu Glu Leu 
        275                 280                 285             


Asn Val Pro Phe Glu Val Pro Ser Pro 
    290                 295         


<210>  4829
<211>  790
<212>  PRT
<213>  Homo sapiens

<400>  4829

Met Arg Ser Val Gln Ile Phe Leu Ser Gln Cys Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Pro Thr Met Leu Leu Lys Ser Leu Gly Glu Asp Val Ile Phe 
            20                  25                  30          


His Pro Glu Gly Glu Phe Asp Ser Tyr Glu Val Thr Ile Pro Glu Lys 
        35                  40                  45              


Leu Ser Phe Arg Gly Glu Val Gln Gly Val Val Ser Pro Val Ser Tyr 
    50                  55                  60                  


Leu Leu Gln Leu Lys Gly Lys Lys His Val Leu His Leu Trp Pro Lys 
65                  70                  75                  80  


Arg Leu Leu Leu Pro Arg His Leu Arg Val Phe Ser Phe Thr Glu His 
                85                  90                  95      


Gly Glu Leu Leu Glu Asp His Pro Tyr Ile Pro Lys Asp Cys Asn Tyr 
            100                 105                 110         


Met Gly Ser Val Lys Glu Ser Leu Asp Ser Lys Ala Thr Ile Ser Thr 
        115                 120                 125             


Cys Met Gly Gly Leu Arg Gly Val Phe Asn Ile Asp Ala Lys His Tyr 
    130                 135                 140                 


Gln Ile Glu Pro Leu Lys Ala Ser Pro Ser Phe Glu His Val Val Tyr 
145                 150                 155                 160 


Leu Leu Lys Lys Glu Gln Phe Gly Asn Gln Val Cys Gly Leu Ser Asp 
                165                 170                 175     


Asp Glu Ile Glu Trp Gln Met Ala Pro Tyr Glu Asn Lys Ala Arg Leu 
            180                 185                 190         


Arg Asp Phe Pro Gly Ser Tyr Lys His Pro Lys Tyr Leu Glu Leu Ile 
        195                 200                 205             


Leu Leu Phe Asp Gln Ser Arg Tyr Arg Phe Val Asn Asn Asn Leu Ser 
    210                 215                 220                 


Gln Val Ile His Asp Ala Ile Leu Leu Thr Gly Ile Met Asp Thr Tyr 
225                 230                 235                 240 


Phe Gln Asp Val Arg Met Arg Ile His Leu Lys Ala Leu Glu Val Trp 
                245                 250                 255     


Thr Asp Phe Asn Lys Ile Arg Val Gly Tyr Pro Glu Leu Ala Glu Val 
            260                 265                 270         


Leu Gly Arg Phe Val Ile Tyr Lys Lys Ser Val Leu Asn Ala Arg Leu 
        275                 280                 285             


Ser Ser Asp Trp Ala His Leu Tyr Leu Gln Arg Lys Tyr Asn Asp Ala 
    290                 295                 300                 


Leu Ala Trp Ser Phe Gly Lys Val Cys Ser Leu Glu Tyr Ala Gly Ser 
305                 310                 315                 320 


Val Ser Thr Leu Leu Asp Thr Asn Ile Leu Ala Pro Ala Thr Trp Ser 
                325                 330                 335     


Ala His Glu Leu Gly His Ala Val Gly Met Ser His Asp Glu Gln Tyr 
            340                 345                 350         


Cys Gln Cys Arg Gly Arg Leu Asn Cys Ile Met Gly Ser Gly Arg Thr 
        355                 360                 365             


Gly Phe Ser Asn Cys Ser Tyr Ile Ser Phe Phe Lys His Ile Ser Ser 
    370                 375                 380                 


Gly Ala Thr Cys Leu Asn Asn Ile Pro Gly Leu Gly Tyr Val Leu Lys 
385                 390                 395                 400 


Arg Cys Gly Asn Lys Ile Val Glu Asp Asn Glu Glu Cys Asp Cys Gly 
                405                 410                 415     


Ser Thr Glu Glu Cys Gln Lys Asp Arg Cys Cys Gln Ser Asn Cys Lys 
            420                 425                 430         


Leu Gln Pro Gly Ala Asn Cys Ser Ile Gly Leu Cys Cys His Asp Cys 
        435                 440                 445             


Arg Phe Arg Pro Ser Gly Tyr Val Cys Arg Gln Glu Gly Asn Glu Cys 
    450                 455                 460                 


Asp Leu Ala Glu Tyr Cys Asp Gly Asn Ser Ser Ser Cys Pro Asn Asp 
465                 470                 475                 480 


Val Tyr Lys Gln Asp Gly Thr Pro Cys Lys Tyr Glu Gly Arg Cys Phe 
                485                 490                 495     


Arg Lys Gly Cys Arg Ser Arg Tyr Met Gln Cys Gln Ser Ile Phe Gly 
            500                 505                 510         


Pro Asp Ala Met Glu Ala Pro Ser Glu Cys Tyr Asp Ala Val Asn Leu 
        515                 520                 525             


Ile Gly Asp Gln Phe Gly Asn Cys Glu Ile Thr Gly Ile Arg Asn Phe 
    530                 535                 540                 


Lys Lys Cys Glu Ser Ala Asn Ser Ile Cys Gly Arg Leu Gln Cys Ile 
545                 550                 555                 560 


Asn Val Glu Thr Ile Pro Asp Leu Pro Glu His Thr Thr Ile Ile Ser 
                565                 570                 575     


Thr His Leu Gln Ala Glu Asn Leu Met Cys Trp Gly Thr Gly Tyr His 
            580                 585                 590         


Leu Ser Met Lys Pro Met Gly Ile Pro Asp Leu Gly Met Ile Asn Asp 
        595                 600                 605             


Gly Thr Ser Cys Gly Glu Gly Arg Val Cys Phe Lys Lys Asn Cys Val 
    610                 615                 620                 


Asn Ser Ser Val Leu Gln Phe Asp Cys Leu Pro Glu Lys Cys Asn Thr 
625                 630                 635                 640 


Arg Gly Val Cys Asn Asn Arg Lys Asn Cys His Cys Met Tyr Gly Trp 
                645                 650                 655     


Ala Pro Pro Phe Cys Glu Glu Val Gly Tyr Gly Gly Ser Ile Asp Ser 
            660                 665                 670         


Gly Pro Pro Gly Leu Leu Arg Gly Ala Ile Pro Ser Ser Ile Trp Val 
        675                 680                 685             


Val Ser Ile Ile Met Phe Arg Leu Ile Leu Leu Ile Leu Ser Val Val 
    690                 695                 700                 


Phe Val Phe Phe Arg Gln Val Ile Gly Asn His Leu Lys Pro Lys Gln 
705                 710                 715                 720 


Glu Lys Met Pro Leu Ser Lys Ala Lys Thr Glu Gln Glu Glu Ser Lys 
                725                 730                 735     


Thr Lys Thr Val Gln Glu Glu Ser Lys Thr Lys Thr Gly Gln Glu Glu 
            740                 745                 750         


Ser Glu Ala Lys Thr Gly Gln Glu Glu Ser Lys Ala Lys Thr Gly Gln 
        755                 760                 765             


Glu Glu Ser Lys Ala Asn Ile Glu Ser Lys Arg Pro Lys Ala Lys Ser 
    770                 775                 780                 


Val Lys Lys Gln Lys Lys 
785                 790 


<210>  4830
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  4830

Met Pro Arg Gly Trp Ala Ala Pro Leu Leu Leu Leu Leu Leu Gln Gly 
1               5                   10                  15      


Gly Trp Gly Cys Pro Asp Leu Val Cys Tyr Thr Asp Tyr Leu Gln Thr 
            20                  25                  30          


Val Ile Cys Ile Leu Glu Met Trp Asn Leu His Pro Ser Thr Leu Thr 
        35                  40                  45              


Leu Thr Trp Gln Asp Gln Tyr Glu Glu Leu Lys Asp Glu Ala Thr Ser 
    50                  55                  60                  


Cys Ser Leu His Arg Ser Ala His Asn Ala Thr His Ala Thr Tyr Thr 
65                  70                  75                  80  


Cys His Met Asp Val Phe His Phe Met Ala Asp Asp Ile Phe Ser Val 
                85                  90                  95      


Asn Ile Thr Asp Gln Ser Gly Asn Tyr Ser Gln Glu Cys Gly Ser Phe 
            100                 105                 110         


Leu Leu Ala Glu Ser Ile Lys Pro Ala Pro Pro Phe Asn Val Thr Val 
        115                 120                 125             


Thr Phe Ser Gly Gln Tyr Asn Ile Ser Trp Arg Ser Asp Tyr Glu Asp 
    130                 135                 140                 


Pro Ala Phe Tyr Met Leu Lys Gly Lys Leu Gln Tyr Glu Leu Gln Tyr 
145                 150                 155                 160 


Arg Asn Arg Gly Asp Pro Trp Ala Val Ser Pro Arg Arg Lys Leu Ile 
                165                 170                 175     


Ser Val Asp Ser Arg Ser Val Ser Leu Leu Pro Leu Glu Phe Arg Lys 
            180                 185                 190         


Asp Ser Ser Tyr Glu Leu Gln Val Arg Ala Gly Pro Met Pro Gly Ser 
        195                 200                 205             


Ser Tyr Gln Gly Thr Trp Ser Glu Trp Ser Asp Pro Val Ile Phe Gln 
    210                 215                 220                 


Thr Gln Ser Glu Glu Leu Lys Glu Gly Trp Asn Pro His Leu Leu Leu 
225                 230                 235                 240 


Leu Leu Leu Leu Val Ile Val Phe Ile Pro Ala Phe Trp Ser Leu Lys 
                245                 250                 255     


Thr His Pro Leu Trp Arg Leu Trp Lys Lys Ile Trp Ala Val Pro Ser 
            260                 265                 270         


Pro Glu Arg Phe Phe Met Pro Leu Tyr Lys Gly Cys Ser Gly Asp Phe 
        275                 280                 285             


Lys Lys Trp Val Gly Ala Pro Phe Thr Gly Ser Ser Leu Glu Leu Gly 
    290                 295                 300                 


Pro Trp Ser Pro Glu Val Pro Ser Thr Leu Glu Val Tyr Ser Cys His 
305                 310                 315                 320 


Pro Pro Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr Glu Leu Gln Glu 
                325                 330                 335     


Pro Ala Glu Leu Val Glu Ser Asp Gly Val Pro Lys Pro Ser Phe Trp 
            340                 345                 350         


Pro Thr Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser Glu Glu Arg Asp 
        355                 360                 365             


Arg Pro Tyr Gly Leu Val Ser Ile Asp Thr Val Thr Val Leu Asp Ala 
    370                 375                 380                 


Glu Gly Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro 
385                 390                 395                 400 


Ala Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly Leu Glu Asp 
                405                 410                 415     


Pro Leu Leu Asp Ala Gly Thr Thr Val Leu Ser Cys Gly Cys Val Ser 
            420                 425                 430         


Ala Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser Leu Leu Asp Arg 
        435                 440                 445             


Leu Lys Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala Gly Gly Leu Pro 
    450                 455                 460                 


Trp Gly Gly Arg Ser Pro Gly Gly Val Ser Glu Ser Glu Ala Gly Ser 
465                 470                 475                 480 


Pro Leu Ala Gly Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Val Gly 
                485                 490                 495     


Ser Asp Cys Ser Ser Pro Val Glu Cys Asp Phe Thr Ser Pro Gly Asp 
            500                 505                 510         


Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val Val Ile Pro Pro 
        515                 520                 525             


Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser 
    530                 535             


<210>  4831
<211>  805
<212>  PRT
<213>  Homo sapiens

<400>  4831

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  4832
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  4832

Met Pro Gly Val Cys Asp Arg Ala Pro Asp Phe Leu Ser Pro Ser Glu 
1               5                   10                  15      


Asp Gln Val Leu Arg Pro Ala Leu Gly Ser Ser Val Ala Leu Asn Cys 
            20                  25                  30          


Thr Ala Trp Val Val Ser Gly Pro His Cys Ser Leu Pro Ser Val Gln 
        35                  40                  45              


Trp Leu Lys Asp Gly Leu Pro Leu Gly Ile Gly Gly His Tyr Ser Leu 
    50                  55                  60                  


His Glu Tyr Ser Trp Val Lys Ala Asn Leu Ser Glu Val Leu Val Ser 
65                  70                  75                  80  


Ser Val Leu Gly Val Asn Val Thr Ser Thr Glu Val Tyr Gly Ala Phe 
                85                  90                  95      


Thr Cys Ser Ile Gln Asn Ile Ser Phe Ser Ser Phe Thr Leu Gln Arg 
            100                 105                 110         


Ala Gly Pro Thr Ser His Val Ala Ala Val Leu Ala Ser Leu Leu Val 
        115                 120                 125             


Leu Leu Ala Leu Leu Leu Ala Ala Leu Leu Tyr Val Lys Cys Arg Leu 
    130                 135                 140                 


Asn Val Leu Leu Trp Tyr Gln Asp Ala Tyr Gly Glu Val Glu Ile Asn 
145                 150                 155                 160 


Asp Gly Lys Leu Tyr Asp Ala Tyr Val Ser Tyr Ser Asp Cys Pro Glu 
                165                 170                 175     


Asp Arg Lys Phe Val Asn Phe Ile Leu Lys Pro Gln Leu Glu Arg Arg 
            180                 185                 190         


Arg Gly Tyr Lys Leu Phe Leu Asp Asp Arg Asp Leu Leu Pro Arg Ala 
        195                 200                 205             


Glu Pro Ser Ala Asp Leu Leu Val Asn Leu Ser Arg Cys Arg Arg Leu 
    210                 215                 220                 


Ile Val Val Leu Ser Asp Ala Phe Leu Ser Arg Ala Trp Cys Ser His 
225                 230                 235                 240 


Ser Phe Arg Glu Gly Leu Cys Arg Leu Leu Glu Leu Thr Arg Arg Pro 
                245                 250                 255     


Ile Phe Ile Thr Phe Glu Gly Gln Arg Arg Asp Pro Ala His Pro Ala 
            260                 265                 270         


Leu Arg Leu Leu Arg Gln His Arg His Leu Val Thr Leu Leu Leu Trp 
        275                 280                 285             


Arg Pro Gly Ser Val Thr Pro Ser Ser Asp Phe Trp Lys Glu Val Gln 
    290                 295                 300                 


Leu Ala Leu Pro Arg Lys Val Gln Tyr Arg Pro Val Glu Gly Asp Pro 
305                 310                 315                 320 


Gln Thr Gln Leu Gln Asp Asp Lys Asp Pro Met Leu Ile Leu Arg Gly 
                325                 330                 335     


Arg Val Pro Glu Gly Arg Ala Leu Asp Ser Glu Val Asp Pro Asp Pro 
            340                 345                 350         


Glu Gly Asp Leu Gly Val Arg Gly Pro Val Phe Gly Glu Pro Ser Ala 
        355                 360                 365             


Pro Pro His Thr Ser Gly Val Ser Leu Gly Glu Ser Arg Ser Ser Glu 
    370                 375                 380                 


Val Asp Val Ser Asp Leu Gly Ser Arg Asn Tyr Ser Ala Arg Thr Asp 
385                 390                 395                 400 


Phe Tyr Cys Leu Val Ser Lys Asp Asp Met 
                405                 410 


<210>  4833
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  4833

Met Arg Leu Ala Gly Pro Leu Arg Ile Val Val Leu Val Val Ser Val 
1               5                   10                  15      


Gly Val Thr Trp Ile Val Val Ser Ile Leu Leu Gly Gly Pro Gly Ser 
            20                  25                  30          


Gly Phe Pro Arg Ile Gln Gln Leu Phe Thr Ser Pro Glu Ser Ser Val 
        35                  40                  45              


Thr Ala Ala Pro Arg Ala Arg Lys Tyr Lys Cys Gly Leu Pro Gln Pro 
    50                  55                  60                  


Cys Pro Glu Glu His Leu Ala Phe Arg Val Val Ser Gly Ala Ala Asn 
65                  70                  75                  80  


Val Ile Gly Pro Lys Ile Cys Leu Glu Asp Lys Met Leu Met Ser Ser 
                85                  90                  95      


Val Lys Asp Asn Val Gly Arg Gly Leu Asn Ile Ala Leu Val Asn Gly 
            100                 105                 110         


Val Ser Gly Glu Leu Ile Glu Ala Arg Ala Phe Asp Met Trp Ala Gly 
        115                 120                 125             


Asp Val Asn Asp Leu Leu Lys Phe Ile Arg Pro Leu His Glu Gly Thr 
    130                 135                 140                 


Leu Val Phe Val Ala Ser Tyr Asp Asp Pro Ala Thr Lys Met Asn Glu 
145                 150                 155                 160 


Glu Thr Arg Lys Leu Phe Ser Glu Leu Gly Ser Arg Asn Ala Lys Glu 
                165                 170                 175     


Leu Ala Phe Arg Asp Ser Trp Val Phe Val Gly Ala Lys Gly Val Gln 
            180                 185                 190         


Asn Lys Ser Pro Phe Glu Gln His Val Lys Asn Ser Lys His Ser Asn 
        195                 200                 205             


Lys Tyr Glu Gly Trp Pro Glu Ala Leu Glu Met Glu Gly Cys Ile Pro 
    210                 215                 220                 


Arg Arg Ser Thr Ala Ser 
225                 230 


<210>  4834
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  4834

Met Glu Val Leu Pro Cys Ser Arg Val Ala His Ile Glu Arg Thr Arg 
1               5                   10                  15      


Lys Pro Tyr Asn Asn Asp Ile Asp Tyr Tyr Ala Lys Arg Asn Ala Leu 
            20                  25                  30          


Arg Ala Ala Glu Val Trp Met Asp Asp Phe Lys Ser His Val Tyr Met 
        35                  40                  45              


Ala Trp Asn Ile Pro Met Ser Asn Pro Gly Val Asp Phe Gly Asp Val 
    50                  55                  60                  


Ser Glu Arg Leu Ala Leu Arg Gln Arg Leu Lys Cys Arg Ser Phe Lys 
65                  70                  75                  80  


Trp Tyr Leu Glu Asn Val Tyr Pro Glu Met Arg Val Tyr Asn Asn Thr 
                85                  90                  95      


Leu Thr Tyr Gly Glu Val Arg Asn Ser Lys Ala Ser Ala Tyr Cys Leu 
            100                 105                 110         


Asp Gln Gly Ala Glu Asp Gly Asp Arg Ala Ile Leu Tyr Pro Cys His 
        115                 120                 125             


Gly Met Ser Ser Gln Leu Val Arg Tyr Ser Ala Asp Gly Leu Leu Gln 
    130                 135                 140                 


Leu Gly Pro Leu Gly Ser Thr Ala Phe Leu Pro Asp Ser Lys Cys Leu 
145                 150                 155                 160 


Val Asp Asp Gly Thr Gly Arg Met Pro Thr Leu Lys Lys Cys Glu Asp 
                165                 170                 175     


Val Ala Arg Pro Thr Gln Arg Leu Trp Asp Phe Thr Gln Ser Gly Pro 
            180                 185                 190         


Ile Val Ser Arg Ala Thr Gly Arg Cys Leu Glu Val Glu Met Ser Lys 
        195                 200                 205             


Asp Ala Asn Phe Gly Leu Arg Leu Val Val Gln Arg Cys Ser Gly Gln 
    210                 215                 220                 


Lys Trp Met Ile Arg Asn Trp Ile Lys His Ala Arg His 
225                 230                 235         


<210>  4835
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  4835

Met Lys Pro Leu Ile Trp Thr Trp Ser Asp Val Glu Gly Gln Arg Pro 
1               5                   10                  15      


Ala Leu Leu Ile Cys Thr Ala Ala Ala Gly Pro Thr Gln Gly Val Lys 
            20                  25                  30          


Asp Leu Glu Glu Val Pro Pro Ser Ala Ala Ser Gln Ser Ala Gln Ala 
        35                  40                  45              


Arg Cys Ala Leu Gly Ser Trp Gly Tyr Gly Lys Pro Phe Glu Pro Arg 
    50                  55                  60                  


Ser Val Lys Asn Ile His Ser Thr Pro Ala Tyr Pro Asp Ala Thr Met 
65                  70                  75                  80  


His Arg Gln Leu Leu Ala Pro Val Glu Gly Arg Met Ala Glu Thr Leu 
                85                  90                  95      


Asn Gln Lys Leu His Val Ala Asn Val Leu Glu Asp Asp Pro Gly Tyr 
            100                 105                 110         


Leu Pro His Val Tyr Ser Glu Glu Gly Glu Cys Gly Gly Ala Pro Ser 
        115                 120                 125             


Leu Ser Ser Leu Ala Ser Leu Glu Gln Glu Leu Gln Pro Asp Leu Leu 
    130                 135                 140                 


Asp Ser Leu Gly Ser Lys Ala Thr Pro Phe Glu Glu Ile Tyr Ser Glu 
145                 150                 155                 160 


Ser Gly Val Pro Ser 
                165 


<210>  4836
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  4836

Met Glu His Phe Asp Ala Ser Leu Ser Thr Tyr Phe Lys Ala Leu Leu 
1               5                   10                  15      


Gly Pro Arg Asp Thr Arg Val Lys Gly Trp Phe Leu Leu Asp Asn Tyr 
            20                  25                  30          


Ile Pro Thr Phe Ile Cys Ser Val Ile Tyr Leu Leu Ile Val Trp Leu 
        35                  40                  45              


Gly Pro Lys Tyr Met Arg Asn Lys Gln Pro Phe Ser Cys Arg Gly Ile 
    50                  55                  60                  


Leu Val Val Tyr Asn Leu Gly Leu Thr Leu Leu Ser Leu Tyr Met Phe 
65                  70                  75                  80  


Cys Glu Leu Val Thr Gly Val Trp Glu Gly Lys Tyr Asn Phe Phe Cys 
                85                  90                  95      


Gln Gly Thr Arg Thr Ala Gly Glu Ser Asp Met Lys Ile Ile Arg Val 
            100                 105                 110         


Leu Trp Trp Tyr Tyr Phe Ser Lys Leu Ile Glu Phe Met Asp Thr Phe 
        115                 120                 125             


Phe Phe Ile Leu Arg Lys Asn Asn His Gln Ile Thr Val Leu His Val 
    130                 135                 140                 


Tyr His His Ala Ser Met Leu Asn Ile Trp Trp Phe Val Met Asn Trp 
145                 150                 155                 160 


Val Pro Cys Gly His Ser Tyr Phe Gly Ala Thr Leu Asn Ser Phe Ile 
                165                 170                 175     


His Val Leu Met Tyr Ser Tyr Tyr Gly Leu Ser Ser Val Pro Ser Met 
            180                 185                 190         


Arg Pro Tyr Leu Trp Trp Lys Lys Tyr Ile Thr Gln Gly Gln Leu Leu 
        195                 200                 205             


Gln Phe Val Leu Thr Ile Ile Gln Thr Ser Cys Gly Val Ile Trp Pro 
    210                 215                 220                 


Cys Thr Phe Pro Leu Gly Trp Leu Tyr Phe Gln Ile Gly Tyr Met Ile 
225                 230                 235                 240 


Ser Leu Ile Ala Leu Phe Thr Asn Phe Tyr Ile Gln Thr Tyr Asn Lys 
                245                 250                 255     


Lys Gly Ala Ser Arg Arg Lys Asp His Leu Lys Asp His Gln Asn Gly 
            260                 265                 270         


Ser Met Ala Ala Val Asn Gly His Thr Asn Ser Phe Ser Pro Leu Glu 
        275                 280                 285             


Asn Asn Val Lys Pro Arg Lys Leu Arg Lys Asp 
    290                 295                 


<210>  4837
<211>  580
<212>  PRT
<213>  Homo sapiens

<400>  4837

Met Ala Phe His Val Glu Gly Leu Ile Ala Ile Ile Val Phe Tyr Leu 
1               5                   10                  15      


Leu Ile Leu Leu Val Gly Ile Trp Ala Ala Trp Arg Thr Lys Asn Ser 
            20                  25                  30          


Gly Ser Ala Glu Glu Arg Ser Glu Ala Ile Ile Val Gly Gly Arg Asp 
        35                  40                  45              


Ile Gly Leu Leu Val Gly Gly Phe Thr Met Thr Ala Thr Trp Val Gly 
    50                  55                  60                  


Gly Gly Tyr Ile Asn Gly Thr Ala Glu Ala Val Tyr Val Pro Gly Tyr 
65                  70                  75                  80  


Gly Leu Ala Trp Ala Gln Ala Pro Ile Gly Tyr Ser Leu Ser Leu Ile 
                85                  90                  95      


Leu Gly Gly Leu Phe Phe Ala Lys Pro Met Arg Ser Lys Gly Tyr Val 
            100                 105                 110         


Thr Met Leu Asp Pro Phe Gln Gln Ile Tyr Gly Lys Arg Met Gly Gly 
        115                 120                 125             


Leu Leu Phe Ile Pro Ala Leu Met Gly Glu Met Phe Trp Ala Ala Ala 
    130                 135                 140                 


Ile Phe Ser Ala Leu Gly Ala Thr Ile Ser Val Ile Ile Asp Val Asp 
145                 150                 155                 160 


Met His Ile Ser Val Ile Ile Ser Ala Leu Ile Ala Thr Leu Tyr Thr 
                165                 170                 175     


Leu Val Gly Gly Leu Tyr Ser Val Ala Tyr Thr Asp Val Val Gln Leu 
            180                 185                 190         


Phe Cys Ile Phe Val Gly Leu Trp Ile Ser Val Pro Phe Ala Leu Ser 
        195                 200                 205             


His Pro Ala Val Ala Asp Ile Gly Phe Thr Ala Val His Ala Lys Tyr 
    210                 215                 220                 


Gln Lys Pro Trp Leu Gly Thr Val Asp Ser Ser Glu Val Tyr Ser Trp 
225                 230                 235                 240 


Leu Asp Ser Phe Leu Leu Leu Met Leu Gly Gly Ile Pro Trp Gln Ala 
                245                 250                 255     


Tyr Phe Gln Arg Val Leu Ser Ser Ser Ser Ala Thr Tyr Ala Gln Val 
            260                 265                 270         


Leu Ser Phe Leu Ala Ala Phe Gly Cys Leu Val Met Ala Ile Pro Ala 
        275                 280                 285             


Ile Leu Ile Gly Ala Ile Gly Ala Ser Thr Asp Trp Asn Gln Thr Ala 
    290                 295                 300                 


Tyr Gly Leu Pro Asp Pro Lys Thr Thr Glu Glu Ala Asp Met Ile Leu 
305                 310                 315                 320 


Pro Ile Val Leu Gln Tyr Leu Cys Pro Val Tyr Ile Ser Phe Phe Gly 
                325                 330                 335     


Leu Gly Ala Val Ser Ala Ala Val Met Ser Ser Ala Asp Ser Ser Ile 
            340                 345                 350         


Leu Ser Ala Ser Ser Met Phe Ala Arg Asn Ile Tyr Gln Leu Ser Phe 
        355                 360                 365             


Arg Gln Asn Ala Ser Asp Lys Glu Ile Val Trp Val Met Arg Ile Thr 
    370                 375                 380                 


Val Phe Val Phe Gly Ala Ser Ala Thr Ala Met Ala Leu Leu Thr Lys 
385                 390                 395                 400 


Thr Val Tyr Gly Leu Trp Tyr Leu Ser Ser Asp Leu Val Tyr Ile Val 
                405                 410                 415     


Ile Phe Pro Gln Leu Leu Cys Val Leu Phe Val Lys Gly Thr Asn Thr 
            420                 425                 430         


Tyr Gly Ala Val Ala Gly Tyr Val Ser Gly Leu Phe Leu Arg Ile Thr 
        435                 440                 445             


Gly Gly Glu Pro Tyr Leu Tyr Leu Gln Pro Leu Ile Phe Tyr Pro Gly 
    450                 455                 460                 


Tyr Tyr Pro Asp Asp Asn Gly Ile Tyr Asn Gln Lys Phe Pro Phe Lys 
465                 470                 475                 480 


Thr Leu Ala Met Val Thr Ser Phe Leu Thr Asn Ile Cys Ile Ser Tyr 
                485                 490                 495     


Leu Ala Lys Tyr Leu Phe Glu Ser Gly Thr Leu Pro Pro Lys Leu Asp 
            500                 505                 510         


Val Phe Asp Ala Val Val Ala Arg His Ser Glu Glu Asn Met Asp Lys 
        515                 520                 525             


Thr Ile Leu Val Lys Asn Glu Asn Ile Lys Leu Asp Glu Leu Ala Leu 
    530                 535                 540                 


Val Lys Pro Arg Gln Ser Met Thr Leu Ser Ser Thr Phe Thr Asn Lys 
545                 550                 555                 560 


Glu Ala Phe Leu Asp Val Asp Ser Ser Pro Glu Gly Ser Gly Thr Glu 
                565                 570                 575     


Asp Asn Leu Gln 
            580 


<210>  4838
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  4838

Met Ser Trp Ser Leu His Pro Arg Asn Leu Ile Leu Tyr Phe Tyr Ala 
1               5                   10                  15      


Leu Leu Phe Leu Ser Ser Thr Cys Val Ala Tyr Val Ala Thr Arg Asp 
            20                  25                  30          


Asn Cys Cys Ile Leu Asp Glu Arg Phe Gly Ser Tyr Cys Pro Thr Thr 
        35                  40                  45              


Cys Gly Ile Ala Asp Phe Leu Ser Thr Tyr Gln Thr Lys Val Asp Lys 
    50                  55                  60                  


Asp Leu Gln Ser Leu Glu Asp Ile Leu His Gln Val Glu Asn Lys Thr 
65                  70                  75                  80  


Ser Glu Val Lys Gln Leu Ile Lys Ala Ile Gln Leu Thr Tyr Asn Pro 
                85                  90                  95      


Asp Glu Ser Ser Lys Pro Asn Met Ile Asp Ala Ala Thr Leu Lys Ser 
            100                 105                 110         


Arg Lys Met Leu Glu Glu Ile Met Lys Tyr Glu Ala Ser Ile Leu Thr 
        115                 120                 125             


His Asp Ser Ser Ile Arg Tyr Leu Gln Glu Ile Tyr Asn Ser Asn Asn 
    130                 135                 140                 


Gln Lys Ile Val Asn Leu Lys Glu Lys Val Ala Gln Leu Glu Ala Gln 
145                 150                 155                 160 


Cys Gln Glu Pro Cys Lys Asp Thr Val Gln Ile His Asp Ile Thr Gly 
                165                 170                 175     


Lys Asp Cys Gln Asp Ile Ala Asn Lys Gly Ala Lys Gln Ser Gly Leu 
            180                 185                 190         


Tyr Phe Ile Lys Pro Leu Lys Ala Asn Gln Gln Phe Leu Val Tyr Cys 
        195                 200                 205             


Glu Ile Asp Gly Ser Gly Asn Gly Trp Thr Val Phe Gln Lys Arg Leu 
    210                 215                 220                 


Asp Gly Ser Val Asp Phe Lys Lys Asn Trp Ile Gln Tyr Lys Glu Gly 
225                 230                 235                 240 


Phe Gly His Leu Ser Pro Thr Gly Thr Thr Glu Phe Trp Leu Gly Asn 
                245                 250                 255     


Glu Lys Ile His Leu Ile Ser Thr Gln Ser Ala Ile Pro Tyr Ala Leu 
            260                 265                 270         


Arg Val Glu Leu Glu Asp Trp Asn Gly Arg Thr Ser Thr Ala Asp Tyr 
        275                 280                 285             


Ala Met Phe Lys Val Gly Pro Glu Ala Asp Lys Tyr Arg Leu Thr Tyr 
    290                 295                 300                 


Ala Tyr Phe Ala Gly Gly Asp Ala Gly Asp Ala Phe Asp Gly Phe Asp 
305                 310                 315                 320 


Phe Gly Asp Asp Pro Ser Asp Lys Phe Phe Thr Ser His Asn Gly Met 
                325                 330                 335     


Gln Phe Ser Thr Trp Asp Asn Asp Asn Asp Lys Phe Glu Gly Asn Cys 
            340                 345                 350         


Ala Glu Gln Asp Gly Ser Gly Trp Trp Met Asn Lys Cys His Ala Gly 
        355                 360                 365             


His Leu Asn Gly Val Tyr Tyr Gln Gly Gly Thr Tyr Ser Lys Ala Ser 
    370                 375                 380                 


Thr Pro Asn Gly Tyr Asp Asn Gly Ile Ile Trp Ala Thr Trp Lys Thr 
385                 390                 395                 400 


Arg Trp Tyr Ser Met Lys Lys Thr Thr Met Lys Ile Ile Pro Phe Asn 
                405                 410                 415     


Arg Leu Thr Ile Gly Glu Gly Gln Gln His His Leu Gly Gly Ala Lys 
            420                 425                 430         


Gln Val Arg Pro Glu His Pro Ala Glu Thr Glu Tyr Asp Ser Leu Tyr 
        435                 440                 445             


Pro Glu Asp Asp Leu 
    450             


<210>  4839
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  4839

Met Ala Ser Leu Gly His Ile Leu Val Phe Cys Val Gly Leu Leu Thr 
1               5                   10                  15      


Met Ala Lys Ala Glu Ser Pro Lys Glu His Asp Pro Phe Thr Tyr Asp 
            20                  25                  30          


Tyr Gln Ser Leu Gln Ile Gly Gly Leu Val Ile Ala Gly Ile Leu Phe 
        35                  40                  45              


Ile Leu Gly Ile Leu Ile Val Leu Ser Arg Arg Cys Arg Cys Lys Phe 
    50                  55                  60                  


Asn Gln Gln Gln Arg Thr Gly Glu Pro Asp Glu Glu Glu Gly Thr Phe 
65                  70                  75                  80  


Arg Ser Ser Ile Arg Arg Leu Ser Thr Arg Arg Arg 
                85                  90          


<210>  4840
<211>  844
<212>  PRT
<213>  Homo sapiens

<400>  4840

Met Gly Pro Gly Ala Pro Phe Ala Arg Val Gly Trp Pro Leu Pro Leu 
1               5                   10                  15      


Leu Val Val Met Ala Ala Gly Val Ala Pro Val Trp Ala Ser His Ser 
            20                  25                  30          


Pro His Leu Pro Arg Pro His Ser Arg Val Pro Pro His Pro Ser Ser 
        35                  40                  45              


Glu Arg Arg Ala Val Tyr Ile Gly Ala Leu Phe Pro Met Ser Gly Gly 
    50                  55                  60                  


Trp Pro Gly Gly Gln Ala Cys Gln Pro Ala Val Glu Met Ala Leu Glu 
65                  70                  75                  80  


Asp Val Asn Ser Arg Arg Asp Ile Leu Pro Asp Tyr Glu Leu Lys Leu 
                85                  90                  95      


Ile His His Asp Ser Lys Cys Asp Pro Gly Gln Ala Thr Lys Tyr Leu 
            100                 105                 110         


Tyr Glu Leu Leu Tyr Asn Asp Pro Ile Lys Ile Ile Leu Met Pro Gly 
        115                 120                 125             


Cys Ser Ser Val Ser Thr Leu Val Ala Glu Ala Ala Arg Met Trp Asn 
    130                 135                 140                 


Leu Ile Val Leu Ser Tyr Gly Ser Ser Ser Pro Ala Leu Ser Asn Arg 
145                 150                 155                 160 


Gln Arg Phe Pro Thr Phe Phe Arg Thr His Pro Ser Ala Thr Leu His 
                165                 170                 175     


Asn Pro Thr Arg Val Lys Leu Phe Glu Lys Trp Gly Trp Lys Lys Ile 
            180                 185                 190         


Ala Thr Ile Gln Gln Thr Thr Glu Val Phe Thr Ser Thr Leu Asp Asp 
        195                 200                 205             


Leu Glu Glu Arg Val Lys Glu Ala Gly Ile Glu Ile Thr Phe Arg Gln 
    210                 215                 220                 


Ser Phe Phe Ser Asp Pro Ala Val Pro Val Lys Asn Leu Lys Arg Gln 
225                 230                 235                 240 


Asp Ala Arg Ile Ile Val Gly Leu Phe Tyr Glu Thr Glu Ala Arg Lys 
                245                 250                 255     


Val Phe Cys Glu Val Tyr Lys Glu Arg Leu Phe Gly Lys Lys Tyr Val 
            260                 265                 270         


Trp Phe Leu Ile Gly Trp Tyr Ala Asp Asn Trp Phe Lys Ile Tyr Asp 
        275                 280                 285             


Pro Ser Ile Asn Cys Thr Val Asp Glu Met Thr Glu Ala Val Glu Gly 
    290                 295                 300                 


His Ile Thr Thr Glu Ile Val Met Leu Asn Pro Ala Asn Thr Arg Ser 
305                 310                 315                 320 


Ile Ser Asn Met Thr Ser Gln Glu Phe Val Glu Lys Leu Thr Lys Arg 
                325                 330                 335     


Leu Lys Arg His Pro Glu Glu Thr Gly Gly Phe Gln Glu Ala Pro Leu 
            340                 345                 350         


Ala Tyr Asp Ala Ile Trp Ala Leu Ala Leu Ala Leu Asn Lys Thr Ser 
        355                 360                 365             


Gly Gly Gly Gly Arg Ser Gly Val Arg Leu Glu Asp Phe Asn Tyr Asn 
    370                 375                 380                 


Asn Gln Thr Ile Thr Asp Gln Ile Tyr Arg Ala Met Asn Ser Ser Ser 
385                 390                 395                 400 


Phe Glu Gly Val Ser Gly His Val Val Phe Asp Ala Ser Gly Ser Arg 
                405                 410                 415     


Met Ala Trp Thr Leu Ile Glu Gln Leu Gln Gly Gly Ser Tyr Lys Lys 
            420                 425                 430         


Ile Gly Tyr Tyr Asp Ser Thr Lys Asp Asp Leu Ser Trp Ser Lys Thr 
        435                 440                 445             


Asp Lys Trp Ile Gly Gly Ser Pro Pro Ala Asp Gln Thr Leu Val Ile 
    450                 455                 460                 


Lys Thr Phe Arg Phe Leu Ser Gln Lys Leu Phe Ile Ser Val Ser Val 
465                 470                 475                 480 


Leu Ser Ser Leu Gly Ile Val Leu Ala Val Val Cys Leu Ser Phe Asn 
                485                 490                 495     


Ile Tyr Asn Ser His Val Arg Tyr Ile Gln Asn Ser Gln Pro Asn Leu 
            500                 505                 510         


Asn Asn Leu Thr Ala Val Gly Cys Ser Leu Ala Leu Ala Ala Val Phe 
        515                 520                 525             


Pro Leu Gly Leu Asp Gly Tyr His Ile Gly Arg Asn Gln Phe Pro Phe 
    530                 535                 540                 


Val Cys Gln Ala Arg Leu Trp Leu Leu Gly Leu Gly Phe Ser Leu Gly 
545                 550                 555                 560 


Tyr Gly Ser Met Phe Thr Lys Ile Trp Trp Val His Thr Val Phe Thr 
                565                 570                 575     


Lys Lys Glu Glu Lys Lys Glu Trp Arg Lys Thr Leu Glu Pro Trp Lys 
            580                 585                 590         


Leu Tyr Ala Thr Val Gly Leu Leu Val Gly Met Asp Val Leu Thr Leu 
        595                 600                 605             


Ala Ile Trp Gln Ile Val Asp Pro Leu His Arg Thr Ile Glu Thr Phe 
    610                 615                 620                 


Ala Lys Glu Glu Pro Lys Glu Asp Ile Asp Val Ser Ile Leu Pro Gln 
625                 630                 635                 640 


Leu Glu His Cys Ser Ser Arg Lys Met Asn Thr Trp Leu Gly Ile Phe 
                645                 650                 655     


Tyr Gly Tyr Lys Gly Leu Leu Leu Leu Leu Gly Ile Phe Leu Ala Tyr 
            660                 665                 670         


Glu Thr Lys Ser Val Ser Thr Glu Lys Ile Asn Asp His Arg Ala Val 
        675                 680                 685             


Gly Met Ala Ile Tyr Asn Val Ala Val Leu Cys Leu Ile Thr Ala Pro 
    690                 695                 700                 


Val Thr Met Ile Leu Ser Ser Gln Gln Asp Ala Ala Phe Ala Phe Ala 
705                 710                 715                 720 


Ser Leu Ala Ile Val Phe Ser Ser Tyr Ile Thr Leu Val Val Leu Phe 
                725                 730                 735     


Val Pro Lys Met Arg Arg Leu Ile Thr Arg Gly Glu Trp Gln Ser Glu 
            740                 745                 750         


Ala Gln Asp Thr Met Lys Thr Gly Ser Ser Thr Asn Asn Asn Glu Glu 
        755                 760                 765             


Glu Lys Ser Arg Leu Leu Glu Lys Glu Asn Arg Glu Leu Glu Lys Ile 
    770                 775                 780                 


Ile Ala Glu Lys Glu Glu Arg Val Ser Glu Leu Arg His Gln Leu Gln 
785                 790                 795                 800 


Ser Arg Gln Gln Leu Arg Ser Arg Arg His Pro Pro Thr Pro Pro Glu 
                805                 810                 815     


Pro Ser Gly Gly Leu Pro Arg Gly Pro Pro Glu Pro Pro Asp Arg Leu 
            820                 825                 830         


Ser Cys Asp Gly Ser Arg Val His Leu Leu Tyr Lys 
        835                 840                 


<210>  4841
<211>  784
<212>  PRT
<213>  Homo sapiens

<400>  4841

Met Ser Gly Gly Trp Pro Gly Gly Gln Ala Cys Gln Pro Ala Val Glu 
1               5                   10                  15      


Met Ala Leu Glu Asp Val Asn Ser Arg Arg Asp Ile Leu Pro Asp Tyr 
            20                  25                  30          


Glu Leu Lys Leu Ile His His Asp Ser Lys Cys Asp Pro Gly Gln Ala 
        35                  40                  45              


Thr Lys Tyr Leu Tyr Glu Leu Leu Tyr Asn Asp Pro Ile Lys Ile Ile 
    50                  55                  60                  


Leu Met Pro Gly Cys Ser Ser Val Ser Thr Leu Val Ala Glu Ala Ala 
65                  70                  75                  80  


Arg Met Trp Asn Leu Ile Val Leu Ser Tyr Gly Ser Ser Ser Pro Ala 
                85                  90                  95      


Leu Ser Asn Arg Gln Arg Phe Pro Thr Phe Phe Arg Thr His Pro Ser 
            100                 105                 110         


Ala Thr Leu His Asn Pro Thr Arg Val Lys Leu Phe Glu Lys Trp Gly 
        115                 120                 125             


Trp Lys Lys Ile Ala Thr Ile Gln Gln Thr Thr Glu Val Phe Thr Ser 
    130                 135                 140                 


Thr Leu Asp Asp Leu Glu Glu Arg Val Lys Glu Ala Gly Ile Glu Ile 
145                 150                 155                 160 


Thr Phe Arg Gln Ser Phe Phe Ser Asp Pro Ala Val Pro Val Lys Asn 
                165                 170                 175     


Leu Lys Arg Gln Asp Ala Arg Ile Ile Val Gly Leu Phe Tyr Glu Thr 
            180                 185                 190         


Glu Ala Arg Lys Val Phe Cys Glu Val Tyr Lys Glu Arg Leu Phe Gly 
        195                 200                 205             


Lys Lys Tyr Val Trp Phe Leu Ile Gly Trp Tyr Ala Asp Asn Trp Phe 
    210                 215                 220                 


Lys Ile Tyr Asp Pro Ser Ile Asn Cys Thr Val Asp Glu Met Thr Glu 
225                 230                 235                 240 


Ala Val Glu Gly His Ile Thr Thr Glu Ile Val Met Leu Asn Pro Ala 
                245                 250                 255     


Asn Thr Arg Ser Ile Ser Asn Met Thr Ser Gln Glu Phe Val Glu Lys 
            260                 265                 270         


Leu Thr Lys Arg Leu Lys Arg His Pro Glu Glu Thr Gly Gly Phe Gln 
        275                 280                 285             


Glu Ala Pro Leu Ala Tyr Asp Ala Ile Trp Ala Leu Ala Leu Ala Leu 
    290                 295                 300                 


Asn Lys Thr Ser Gly Gly Gly Gly Arg Ser Gly Val Arg Leu Glu Asp 
305                 310                 315                 320 


Phe Asn Tyr Asn Asn Gln Thr Ile Thr Asp Gln Ile Tyr Arg Ala Met 
                325                 330                 335     


Asn Ser Ser Ser Phe Glu Gly Val Ser Gly His Val Val Phe Asp Ala 
            340                 345                 350         


Ser Gly Ser Arg Met Ala Trp Thr Leu Ile Glu Gln Leu Gln Gly Gly 
        355                 360                 365             


Ser Tyr Lys Lys Ile Gly Tyr Tyr Asp Ser Thr Lys Asp Asp Leu Ser 
    370                 375                 380                 


Trp Ser Lys Thr Asp Lys Trp Ile Gly Gly Ser Pro Pro Ala Asp Gln 
385                 390                 395                 400 


Thr Leu Val Ile Lys Thr Phe Arg Phe Leu Ser Gln Lys Leu Phe Ile 
                405                 410                 415     


Ser Val Ser Val Leu Ser Ser Leu Gly Ile Val Leu Ala Val Val Cys 
            420                 425                 430         


Leu Ser Phe Asn Ile Tyr Asn Ser His Val Arg Tyr Ile Gln Asn Ser 
        435                 440                 445             


Gln Pro Asn Leu Asn Asn Leu Thr Ala Val Gly Cys Ser Leu Ala Leu 
    450                 455                 460                 


Ala Ala Val Phe Pro Leu Gly Leu Asp Gly Tyr His Ile Gly Arg Asn 
465                 470                 475                 480 


Gln Phe Pro Phe Val Cys Gln Ala Arg Leu Trp Leu Leu Gly Leu Gly 
                485                 490                 495     


Phe Ser Leu Gly Tyr Gly Ser Met Phe Thr Lys Ile Trp Trp Val His 
            500                 505                 510         


Thr Val Phe Thr Lys Lys Glu Glu Lys Lys Glu Trp Arg Lys Thr Leu 
        515                 520                 525             


Glu Pro Trp Lys Leu Tyr Ala Thr Val Gly Leu Leu Val Gly Met Asp 
    530                 535                 540                 


Val Leu Thr Leu Ala Ile Trp Gln Ile Val Asp Pro Leu His Arg Thr 
545                 550                 555                 560 


Ile Glu Thr Phe Ala Lys Glu Glu Pro Lys Glu Asp Ile Asp Val Ser 
                565                 570                 575     


Ile Leu Pro Gln Leu Glu His Cys Ser Ser Arg Lys Met Asn Thr Trp 
            580                 585                 590         


Leu Gly Ile Phe Tyr Gly Tyr Lys Gly Leu Leu Leu Leu Leu Gly Ile 
        595                 600                 605             


Phe Leu Ala Tyr Glu Thr Lys Ser Val Ser Thr Glu Lys Ile Asn Asp 
    610                 615                 620                 


His Arg Ala Val Gly Met Ala Ile Tyr Asn Val Ala Val Leu Cys Leu 
625                 630                 635                 640 


Ile Thr Ala Pro Val Thr Met Ile Leu Ser Ser Gln Gln Asp Ala Ala 
                645                 650                 655     


Phe Ala Phe Ala Ser Leu Ala Ile Val Phe Ser Ser Tyr Ile Thr Leu 
            660                 665                 670         


Val Val Leu Phe Val Pro Lys Met Arg Arg Leu Ile Thr Arg Gly Glu 
        675                 680                 685             


Trp Gln Ser Glu Ala Gln Asp Thr Met Lys Thr Gly Ser Ser Thr Asn 
    690                 695                 700                 


Asn Asn Glu Glu Glu Lys Ser Arg Leu Leu Glu Lys Glu Asn Arg Glu 
705                 710                 715                 720 


Leu Glu Lys Ile Ile Ala Glu Lys Glu Glu Arg Val Ser Glu Leu Arg 
                725                 730                 735     


His Gln Leu Gln Ser Arg Gln Gln Leu Arg Ser Arg Arg His Pro Pro 
            740                 745                 750         


Thr Pro Pro Glu Pro Ser Gly Gly Leu Pro Arg Gly Pro Pro Glu Pro 
        755                 760                 765             


Pro Asp Arg Leu Ser Cys Asp Gly Ser Arg Val His Leu Leu Tyr Lys 
    770                 775                 780                 


<210>  4842
<211>  899
<212>  PRT
<213>  Homo sapiens

<400>  4842

Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe Leu Arg Pro Pro Gly 
1               5                   10                  15      


Ala Gly Gly Ala Gln Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile 
            20                  25                  30          


Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg 
        35                  40                  45              


Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu 
    50                  55                  60                  


Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys 
65                  70                  75                  80  


Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys 
                85                  90                  95      


Val Asn Arg Thr Pro His Ser Glu Arg Arg Ala Val Tyr Ile Gly Ala 
            100                 105                 110         


Leu Phe Pro Met Ser Gly Gly Trp Pro Gly Gly Gln Ala Cys Gln Pro 
        115                 120                 125             


Ala Val Glu Met Ala Leu Glu Asp Val Asn Ser Arg Arg Asp Ile Leu 
    130                 135                 140                 


Pro Asp Tyr Glu Leu Lys Leu Ile His His Asp Ser Lys Cys Asp Pro 
145                 150                 155                 160 


Gly Gln Ala Thr Lys Tyr Leu Tyr Glu Leu Leu Tyr Asn Asp Pro Ile 
                165                 170                 175     


Lys Ile Ile Leu Met Pro Gly Cys Ser Ser Val Ser Thr Leu Val Ala 
            180                 185                 190         


Glu Ala Ala Arg Met Trp Asn Leu Ile Val Leu Ser Tyr Gly Ser Ser 
        195                 200                 205             


Ser Pro Ala Leu Ser Asn Arg Gln Arg Phe Pro Thr Phe Phe Arg Thr 
    210                 215                 220                 


His Pro Ser Ala Thr Leu His Asn Pro Thr Arg Val Lys Leu Phe Glu 
225                 230                 235                 240 


Lys Trp Gly Trp Lys Lys Ile Ala Thr Ile Gln Gln Thr Thr Glu Val 
                245                 250                 255     


Phe Thr Ser Thr Leu Asp Asp Leu Glu Glu Arg Val Lys Glu Ala Gly 
            260                 265                 270         


Ile Glu Ile Thr Phe Arg Gln Ser Phe Phe Ser Asp Pro Ala Val Pro 
        275                 280                 285             


Val Lys Asn Leu Lys Arg Gln Asp Ala Arg Ile Ile Val Gly Leu Phe 
    290                 295                 300                 


Tyr Glu Thr Glu Ala Arg Lys Val Phe Cys Glu Val Tyr Lys Glu Arg 
305                 310                 315                 320 


Leu Phe Gly Lys Lys Tyr Val Trp Phe Leu Ile Gly Trp Tyr Ala Asp 
                325                 330                 335     


Asn Trp Phe Lys Ile Tyr Asp Pro Ser Ile Asn Cys Thr Val Asp Glu 
            340                 345                 350         


Met Thr Glu Ala Val Glu Gly His Ile Thr Thr Glu Ile Val Met Leu 
        355                 360                 365             


Asn Pro Ala Asn Thr Arg Ser Ile Ser Asn Met Thr Ser Gln Glu Phe 
    370                 375                 380                 


Val Glu Lys Leu Thr Lys Arg Leu Lys Arg His Pro Glu Glu Thr Gly 
385                 390                 395                 400 


Gly Phe Gln Glu Ala Pro Leu Ala Tyr Asp Ala Ile Trp Ala Leu Ala 
                405                 410                 415     


Leu Ala Leu Asn Lys Thr Ser Gly Gly Gly Gly Arg Ser Gly Val Arg 
            420                 425                 430         


Leu Glu Asp Phe Asn Tyr Asn Asn Gln Thr Ile Thr Asp Gln Ile Tyr 
        435                 440                 445             


Arg Ala Met Asn Ser Ser Ser Phe Glu Gly Val Ser Gly His Val Val 
    450                 455                 460                 


Phe Asp Ala Ser Gly Ser Arg Met Ala Trp Thr Leu Ile Glu Gln Leu 
465                 470                 475                 480 


Gln Gly Gly Ser Tyr Lys Lys Ile Gly Tyr Tyr Asp Ser Thr Lys Asp 
                485                 490                 495     


Asp Leu Ser Trp Ser Lys Thr Asp Lys Trp Ile Gly Gly Ser Pro Pro 
            500                 505                 510         


Ala Asp Gln Thr Leu Val Ile Lys Thr Phe Arg Phe Leu Ser Gln Lys 
        515                 520                 525             


Leu Phe Ile Ser Val Ser Val Leu Ser Ser Leu Gly Ile Val Leu Ala 
    530                 535                 540                 


Val Val Cys Leu Ser Phe Asn Ile Tyr Asn Ser His Val Arg Tyr Ile 
545                 550                 555                 560 


Gln Asn Ser Gln Pro Asn Leu Asn Asn Leu Thr Ala Val Gly Cys Ser 
                565                 570                 575     


Leu Ala Leu Ala Ala Val Phe Pro Leu Gly Leu Asp Gly Tyr His Ile 
            580                 585                 590         


Gly Arg Asn Gln Phe Pro Phe Val Cys Gln Ala Arg Leu Trp Leu Leu 
        595                 600                 605             


Gly Leu Gly Phe Ser Leu Gly Tyr Gly Ser Met Phe Thr Lys Ile Trp 
    610                 615                 620                 


Trp Val His Thr Val Phe Thr Lys Lys Glu Glu Lys Lys Glu Trp Arg 
625                 630                 635                 640 


Lys Thr Leu Glu Pro Trp Lys Leu Tyr Ala Thr Val Gly Leu Leu Val 
                645                 650                 655     


Gly Met Asp Val Leu Thr Leu Ala Ile Trp Gln Ile Val Asp Pro Leu 
            660                 665                 670         


His Arg Thr Ile Glu Thr Phe Ala Lys Glu Glu Pro Lys Glu Asp Ile 
        675                 680                 685             


Asp Val Ser Ile Leu Pro Gln Leu Glu His Cys Ser Ser Arg Lys Met 
    690                 695                 700                 


Asn Thr Trp Leu Gly Ile Phe Tyr Gly Tyr Lys Gly Leu Leu Leu Leu 
705                 710                 715                 720 


Leu Gly Ile Phe Leu Ala Tyr Glu Thr Lys Ser Val Ser Thr Glu Lys 
                725                 730                 735     


Ile Asn Asp His Arg Ala Val Gly Met Ala Ile Tyr Asn Val Ala Val 
            740                 745                 750         


Leu Cys Leu Ile Thr Ala Pro Val Thr Met Ile Leu Ser Ser Gln Gln 
        755                 760                 765             


Asp Ala Ala Phe Ala Phe Ala Ser Leu Ala Ile Val Phe Ser Ser Tyr 
    770                 775                 780                 


Ile Thr Leu Val Val Leu Phe Val Pro Lys Met Arg Arg Leu Ile Thr 
785                 790                 795                 800 


Arg Gly Glu Trp Gln Ser Glu Ala Gln Asp Thr Met Lys Thr Gly Ser 
                805                 810                 815     


Ser Thr Asn Asn Asn Glu Glu Glu Lys Ser Arg Leu Leu Glu Lys Glu 
            820                 825                 830         


Asn Arg Glu Leu Glu Lys Ile Ile Ala Glu Lys Glu Glu Arg Val Ser 
        835                 840                 845             


Glu Leu Arg His Gln Leu Gln Ser Arg Gln Gln Leu Arg Ser Arg Arg 
    850                 855                 860                 


His Pro Pro Thr Pro Pro Glu Pro Ser Gly Gly Leu Pro Arg Gly Pro 
865                 870                 875                 880 


Pro Glu Pro Pro Asp Arg Leu Ser Cys Asp Gly Ser Arg Val His Leu 
                885                 890                 895     


Leu Tyr Lys 
            


<210>  4843
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  4843

Met Ala Glu Ala Ala Thr Gly Phe Leu Glu Gln Leu Lys Ser Cys Ile 
1               5                   10                  15      


Val Trp Ser Trp Thr Tyr Leu Trp Thr Val Trp Phe Phe Ile Val Leu 
            20                  25                  30          


Phe Leu Val Tyr Ile Leu Arg Val Pro Leu Lys Ile Asn Asp Asn Leu 
        35                  40                  45              


Ser Thr Val Ser Met Phe Leu Asn Thr Leu Thr Pro Lys Phe Tyr Val 
    50                  55                  60                  


Ala Leu Thr Gly Thr Ser Ser Leu Ile Ser Gly Leu Ile Leu Ile Phe 
65                  70                  75                  80  


Glu Trp Trp Tyr Phe Arg Lys Tyr Gly Thr Ser Phe Ile Glu Gln Val 
                85                  90                  95      


Ser Val Ser His Leu Arg Pro Leu Leu Gly Gly Val Asp Asn Asn Ser 
            100                 105                 110         


Ser Asn Asn Ser Asn Ser Ser Asn Gly Asp Ser Asp Ser Asn Arg Gln 
        115                 120                 125             


Ser Val Ser Glu Cys Lys Val Trp Arg Asn Pro Leu Asn Leu Phe Arg 
    130                 135                 140                 


Gly Ala Glu Tyr Asn Arg Tyr Thr Trp Val Thr Gly Arg Glu Pro Leu 
145                 150                 155                 160 


Thr Tyr Tyr Asp Met Asn Leu Ser Ala Gln Asp His Gln Thr Phe Phe 
                165                 170                 175     


Thr Cys Asp Ser Asp His Leu Arg Pro Ala Asp Ala Ile Met Gln Lys 
            180                 185                 190         


Ala Trp Arg Glu Arg Asn Pro Gln Ala Arg Ile Ser Ala Ala His Glu 
        195                 200                 205             


Ala Leu Glu Ile Asn Glu Ile Arg Ser Arg Val Glu Val Pro Leu Ile 
    210                 215                 220                 


Ala Ser Ser Thr Ile Trp Glu Ile Lys Leu Leu Pro Lys Cys Ala Thr 
225                 230                 235                 240 


Ala Tyr Ile Leu Leu Ala Glu Glu Glu Ala Thr Thr Ile Ala Glu Ala 
                245                 250                 255     


Glu Lys Leu Phe Lys Gln Ala Leu Lys Ala Gly Asp Gly Cys Tyr Arg 
            260                 265                 270         


Arg Ser Gln Gln Leu Gln His His Gly Ser Gln Tyr Glu Ala Gln His 
        275                 280                 285             


Arg Arg Asp Thr Asn Val Leu Val Tyr Ile Lys Arg Arg Leu Ala Met 
    290                 295                 300                 


Cys Ala Arg Arg Leu Gly Arg Thr Arg Glu Ala Val Lys Met Met Arg 
305                 310                 315                 320 


Asp Leu Met Lys Glu Phe Pro Leu Leu Ser Met Phe Asn Ile His Glu 
                325                 330                 335     


Asn Leu Leu Glu Ala Leu Leu Glu Leu Gln Ala Tyr Ala Asp Val Gln 
            340                 345                 350         


Ala Val Leu Ala Lys Tyr Asp Asp Ile Ser Leu Pro Lys Ser Ala Thr 
        355                 360                 365             


Ile Cys Tyr Thr Ala Ala Leu Leu Lys Ala Arg Ala Val Ser Asp Lys 
    370                 375                 380                 


Phe Ser Pro Glu Ala Ala Ser Arg Arg Gly Leu Ser Thr Ala Glu Met 
385                 390                 395                 400 


Asn Ala Val Glu Ala Ile His Arg Ala Val Glu Phe Asn Pro His Val 
                405                 410                 415     


Pro Lys Tyr Leu Leu Glu Met Lys Ser Leu Ile Leu Pro Pro Glu His 
            420                 425                 430         


Ile Leu Lys Arg Gly Asp Ser Glu Ala Ile Ala Tyr Ala Phe Phe His 
        435                 440                 445             


Leu Ala His Trp Lys Arg Val Glu Gly Ala Leu Asn Leu Leu His Cys 
    450                 455                 460                 


Thr Trp Glu Gly Thr Phe Arg Met Ile Pro Tyr Pro Leu Glu Lys Gly 
465                 470                 475                 480 


His Leu Phe Tyr Pro Tyr Pro Ile Cys Thr Glu Thr Ala Asp Arg Glu 
                485                 490                 495     


Leu Leu Pro Ser Phe His Glu Val Ser Val Tyr Pro Lys Lys Glu Leu 
            500                 505                 510         


Pro Phe Phe Ile Leu Phe Thr Ala Gly Leu Cys Ser Phe Thr Ala Met 
        515                 520                 525             


Leu Ala Leu Leu Thr His Gln Phe Pro Glu Leu Met Gly Val Phe Ala 
    530                 535                 540                 


Lys Ala Met Ile Asp Ile Phe Cys Ser Ala Glu Phe Arg Asp Trp Asn 
545                 550                 555                 560 


Cys Lys Ser Ile Phe Met Arg Val Glu Asp Glu Leu Glu Ile Pro Pro 
                565                 570                 575     


Ala Pro Gln Ser Gln His Phe Gln Asn 
            580                 585 


<210>  4844
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  4844

Met Gln Lys Val Thr Leu Gly Leu Leu Val Phe Leu Ala Gly Phe Pro 
1               5                   10                  15      


Val Leu Asp Ala Asn Asp Leu Glu Asp Lys Asn Ser Pro Phe Tyr Tyr 
            20                  25                  30          


Asp Trp His Ser Leu Gln Val Gly Gly Leu Ile Cys Ala Gly Val Leu 
        35                  40                  45              


Cys Ala Met Gly Ile Ile Ile Val Met Ser Glu Trp Arg Ser Ser Gly 
    50                  55                  60                  


Glu Gln Ala Gly Arg Gly Trp Gly Ser Pro Pro Leu Thr Thr Gln Leu 
65                  70                  75                  80  


Ser Pro Thr Gly Ala Lys Cys Lys Cys Lys Phe Gly Gln Lys Ser Gly 
                85                  90                  95      


His His Pro Gly Glu Thr Pro Pro Leu Ile Thr Pro Gly Ser Ala Gln 
            100                 105                 110         


Ser 
    


<210>  4845
<211>  512
<212>  PRT
<213>  Homo sapiens

<400>  4845

Met Trp Arg Val Arg Lys Arg Gly Tyr Phe Gly Ile Trp Ser Phe Pro 
1               5                   10                  15      


Leu Ile Ile Ala Ala Val Cys Ala Gln Ser Val Asn Asp Pro Ser Asn 
            20                  25                  30          


Met Ser Leu Val Lys Glu Thr Val Asp Arg Leu Leu Lys Gly Tyr Asp 
        35                  40                  45              


Ile Arg Leu Arg Pro Asp Phe Gly Gly Pro Pro Val Ala Val Gly Met 
    50                  55                  60                  


Asn Ile Asp Ile Ala Ser Ile Asp Met Val Ser Glu Val Asn Met Asp 
65                  70                  75                  80  


Tyr Thr Leu Thr Met Tyr Phe Gln Gln Ala Trp Arg Asp Lys Arg Leu 
                85                  90                  95      


Ser Tyr Asn Val Ile Pro Leu Asn Leu Thr Leu Asp Asn Arg Val Ala 
            100                 105                 110         


Asp Gln Leu Trp Val Pro Asp Thr Tyr Phe Leu Asn Asp Lys Lys Ser 
        115                 120                 125             


Phe Val His Gly Val Thr Val Lys Asn Arg Met Ile Arg Leu His Pro 
    130                 135                 140                 


Asp Gly Thr Val Leu Tyr Gly Leu Arg Ile Thr Thr Thr Ala Ala Cys 
145                 150                 155                 160 


Met Met Asp Leu Arg Arg Tyr Pro Leu Asp Glu Gln Asn Cys Thr Leu 
                165                 170                 175     


Glu Ile Glu Ser Tyr Gly Tyr Thr Thr Asp Asp Ile Glu Phe Tyr Trp 
            180                 185                 190         


Arg Gly Asp Asp Asn Ala Val Thr Gly Val Thr Lys Ile Glu Leu Pro 
        195                 200                 205             


Gln Phe Ser Ile Val Asp Tyr Lys Leu Ile Thr Lys Lys Val Val Phe 
    210                 215                 220                 


Ser Thr Gly Ser Tyr Pro Arg Leu Ser Leu Ser Phe Lys Leu Lys Arg 
225                 230                 235                 240 


Asn Ile Gly Tyr Phe Ile Leu Gln Thr Tyr Met Pro Ser Ile Leu Ile 
                245                 250                 255     


Thr Ile Leu Ser Trp Val Ser Phe Trp Ile Asn Tyr Asp Ala Ser Ala 
            260                 265                 270         


Ala Arg Val Ala Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr Ile 
        275                 280                 285             


Asn Thr His Leu Arg Glu Thr Leu Pro Lys Ile Pro Tyr Val Lys Ala 
    290                 295                 300                 


Ile Asp Met Tyr Leu Met Gly Cys Phe Val Phe Val Phe Met Ala Leu 
305                 310                 315                 320 


Leu Glu Tyr Ala Leu Val Asn Tyr Ile Phe Phe Gly Arg Gly Pro Gln 
                325                 330                 335     


Arg Gln Lys Lys Ala Ala Glu Lys Ala Ala Ser Ala Asn Asn Glu Lys 
            340                 345                 350         


Met Arg Leu Asp Val Asn Lys Ile Phe Tyr Lys Asp Ile Lys Gln Asn 
        355                 360                 365             


Gly Thr Gln Tyr Arg Ser Leu Trp Asp Pro Thr Gly Asn Leu Ser Pro 
    370                 375                 380                 


Thr Arg Arg Thr Thr Asn Tyr Asp Phe Ser Leu Tyr Thr Met Asp Pro 
385                 390                 395                 400 


His Glu Asn Ile Leu Leu Ser Thr Leu Glu Ile Lys Asn Glu Met Ala 
                405                 410                 415     


Thr Ser Glu Ala Val Met Gly Leu Gly Asp Pro Arg Ser Thr Met Leu 
            420                 425                 430         


Ala Tyr Asp Ala Ser Ser Ile Gln Tyr Arg Lys Ala Gly Leu Pro Arg 
        435                 440                 445             


His Ser Phe Gly Arg Asn Ala Leu Glu Arg His Val Ala Gln Lys Lys 
    450                 455                 460                 


Ser Arg Leu Arg Arg Arg Ala Ser Gln Leu Lys Ile Thr Ile Pro Asp 
465                 470                 475                 480 


Leu Thr Asp Val Asn Ala Ile Asp Arg Trp Ser Arg Ile Phe Phe Pro 
                485                 490                 495     


Val Val Phe Ser Phe Phe Asn Ile Val Tyr Trp Leu Tyr Tyr Val Asn 
            500                 505                 510         


<210>  4846
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  4846

Met Cys Ser Gly Leu Leu Glu Leu Leu Leu Pro Ile Trp Leu Ser Trp 
1               5                   10                  15      


Thr Leu Gly Thr Arg Gly Ser Glu Pro Arg Ser Val Asn Asp Pro Gly 
            20                  25                  30          


Asn Met Ser Phe Val Lys Glu Thr Val Asp Lys Leu Leu Lys Gly Tyr 
        35                  40                  45              


Asp Ile Arg Leu Arg Pro Asp Phe Gly Gly Pro Pro Val Cys Val Gly 
    50                  55                  60                  


Met Asn Ile Asp Ile Ala Ser Ile Asp Met Val Ser Glu Val Asn Met 
65                  70                  75                  80  


Asp Tyr Thr Leu Thr Met Tyr Phe Gln Gln Tyr Trp Arg Asp Lys Arg 
                85                  90                  95      


Leu Ala Tyr Ser Gly Ile Pro Leu Asn Leu Thr Leu Asp Asn Arg Val 
            100                 105                 110         


Ala Asp Gln Leu Trp Val Pro Asp Thr Tyr Phe Leu Asn Asp Lys Lys 
        115                 120                 125             


Ser Phe Val His Gly Val Thr Val Lys Asn Arg Met Ile Arg Leu His 
    130                 135                 140                 


Pro Asp Gly Thr Val Leu Tyr Gly Leu Arg Ile Thr Thr Thr Ala Ala 
145                 150                 155                 160 


Cys Met Met Asp Leu Arg Arg Tyr Pro Leu Asp Glu Gln Asn Cys Thr 
                165                 170                 175     


Leu Glu Ile Glu Ser Tyr Gly Tyr Thr Thr Asp Asp Ile Glu Phe Tyr 
            180                 185                 190         


Trp Arg Gly Gly Asp Lys Ala Val Thr Gly Val Glu Arg Ile Glu Leu 
        195                 200                 205             


Pro Gln Phe Ser Ile Val Glu His Arg Leu Val Ser Arg Asn Val Val 
    210                 215                 220                 


Phe Ala Thr Gly Ala Tyr Pro Arg Leu Ser Leu Ser Phe Arg Leu Lys 
225                 230                 235                 240 


Arg Asn Ile Gly Tyr Phe Ile Leu Gln Thr Tyr Met Pro Ser Ile Leu 
                245                 250                 255     


Ile Thr Ile Leu Ser Trp Val Ser Phe Trp Ile Asn Tyr Asp Ala Ser 
            260                 265                 270         


Ala Ala Arg Val Ala Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr 
        275                 280                 285             


Ile Asn Thr His Leu Arg Glu Thr Leu Pro Lys Ile Pro Tyr Val Lys 
    290                 295                 300                 


Ala Ile Asp Met Tyr Leu Met Gly Cys Phe Val Phe Val Phe Leu Ala 
305                 310                 315                 320 


Leu Leu Glu Tyr Ala Phe Val Asn Tyr Ile Phe Phe Gly Arg Gly Pro 
                325                 330                 335     


Gln Arg Gln Lys Lys Leu Ala Glu Lys Thr Ala Lys Ala Lys Asn Asp 
            340                 345                 350         


Arg Ser Lys Ser Glu Ser Asn Arg Val Asp Ala His Gly Asn Ile Leu 
        355                 360                 365             


Leu Thr Ser Leu Glu Val His Asn Glu Met Asn Glu Val Ser Gly Gly 
    370                 375                 380                 


Ile Gly Asp Thr Arg Asn Ser Ala Ile Ser Phe Asp Asn Ser Gly Ile 
385                 390                 395                 400 


Gln Tyr Arg Lys Gln Ser Met Pro Arg Glu Gly His Gly Arg Phe Leu 
                405                 410                 415     


Gly Asp Arg Ser Leu Pro His Lys Lys Thr His Leu Arg Arg Arg Ser 
            420                 425                 430         


Ser Gln Leu Lys Ile Lys Ile Pro Asp Leu Thr Asp Val Asn Ala Ile 
        435                 440                 445             


Asp Arg Trp Ser Arg Ile Val Phe Pro Phe Thr Phe Ser Leu Phe Asn 
    450                 455                 460                 


Leu Val Tyr Trp Leu Tyr Tyr Val Asn 
465                 470             


<210>  4847
<211>  894
<212>  PRT
<213>  Homo sapiens

<400>  4847

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln 
            420                 425                 430         


Pro Val His Gln Leu Val Lys Glu Pro Ser Thr Pro Ala Phe Ser Trp 
        435                 440                 445             


Pro Trp Trp Tyr Val Leu Leu Gly Ala Val Val Ala Ala Ala Cys Val 
    450                 455                 460                 


Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys Lys Glu Thr Arg 
465                 470                 475                 480 


Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val 
                485                 490                 495     


Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr 
            500                 505                 510         


Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp 
        515                 520                 525             


Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu 
    530                 535                 540                 


Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser 
545                 550                 555                 560 


Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg 
                565                 570                 575     


Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe 
            580                 585                 590         


Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser 
        595                 600                 605             


Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys 
    610                 615                 620                 


His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln 
625                 630                 635                 640 


Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile 
                645                 650                 655     


Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp 
            660                 665                 670         


Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val 
        675                 680                 685             


Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg 
    690                 695                 700                 


Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser 
705                 710                 715                 720 


Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly 
                725                 730                 735     


Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly 
            740                 745                 750         


Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu 
        755                 760                 765             


Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg 
    770                 775                 780                 


Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Thr Glu Leu Arg 
785                 790                 795                 800 


Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro 
                805                 810                 815     


Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu 
            820                 825                 830         


Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro 
        835                 840                 845             


Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val His Pro Ala Gly 
    850                 855                 860                 


Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro Ala Gln Pro Ala 
865                 870                 875                 880 


Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala 
                885                 890                 


<210>  4848
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  4848

Met Thr Pro Ser Pro Leu Leu Leu Leu Leu Leu Pro Pro Leu Leu Leu 
1               5                   10                  15      


Gly Ala Phe Pro Pro Ala Ala Ala Ala Arg Gly Pro Pro Lys Met Ala 
            20                  25                  30          


Asp Lys Val Val Pro Arg Gln Val Ala Arg Leu Gly Arg Thr Val Arg 
        35                  40                  45              


Leu Gln Cys Pro Val Glu Gly Asp Pro Pro Pro Leu Thr Met Trp Thr 
    50                  55                  60                  


Lys Asp Gly Arg Thr Ile His Ser Gly Trp Ser Arg Phe Arg Val Leu 
65                  70                  75                  80  


Pro Gln Gly Leu Lys Val Lys Gln Val Glu Arg Glu Asp Ala Gly Val 
                85                  90                  95      


Tyr Val Cys Lys Ala Thr Asn Gly Phe Gly Ser Leu Ser Val Asn Tyr 
            100                 105                 110         


Thr Leu Val Val Leu Asp Asp Ile Ser Pro Gly Lys Glu Ser Leu Gly 
        115                 120                 125             


Pro Asp Ser Ser Ser Gly Gly Gln Glu Asp Pro Ala Ser Gln Gln Trp 
    130                 135                 140                 


Ala Arg Pro Arg Phe Thr Gln Pro Ser Lys Met Arg Arg Arg Val Ile 
145                 150                 155                 160 


Ala Arg Pro Val Gly Ser Ser Val Arg Leu Lys Cys Val Ala Ser Gly 
                165                 170                 175     


His Pro Arg Pro Asp Ile Thr Trp Met Lys Asp Asp Gln Ala Leu Thr 
            180                 185                 190         


Arg Pro Glu Ala Ala Glu Pro Arg Lys Lys Lys Trp Thr Leu Ser Leu 
        195                 200                 205             


Lys Asn Leu Arg Pro Glu Asp Ser Gly Lys Tyr Thr Cys Arg Val Ser 
    210                 215                 220                 


Asn Arg Ala Gly Ala Ile Asn Ala Thr Tyr Lys Val Asp Val Ile Gln 
225                 230                 235                 240 


Arg Thr Arg Ser Lys Pro Val Leu Thr Gly Thr His Pro Val Asn Thr 
                245                 250                 255     


Thr Val Asp Phe Gly Gly Thr Thr Ser Phe Gln Cys Lys Val Arg Ser 
            260                 265                 270         


Asp Val Lys Pro Val Ile Gln Trp Leu Lys Arg Val Glu Tyr Gly Ala 
        275                 280                 285             


Glu Gly Arg His Asn Ser Thr Ile Asp Val Gly Gly Gln Lys Phe Val 
    290                 295                 300                 


Val Leu Pro Thr Gly Asp Val Trp Ser Arg Pro Asp Gly Ser Tyr Leu 
305                 310                 315                 320 


Asn Lys Leu Leu Ile Thr Arg Ala Arg Gln Asp Asp Ala Gly Met Tyr 
                325                 330                 335     


Ile Cys Leu Gly Ala Asn Thr Met Gly Tyr Ser Phe Arg Ser Ala Phe 
            340                 345                 350         


Leu Thr Val Leu Pro Asp Pro Lys Pro Pro Gly Pro Pro Val Ala Ser 
        355                 360                 365             


Ser Ser Ser Ala Thr Ser Leu Pro Trp Pro Val Val Ile Gly Ile Pro 
    370                 375                 380                 


Ala Gly Ala Val Phe Ile Leu Gly Thr Leu Leu Leu Trp Leu Cys Gln 
385                 390                 395                 400 


Ala Gln Lys Lys Pro Cys Thr Pro Ala Pro Ala Pro Pro Leu Pro Gly 
                405                 410                 415     


His Arg Pro Pro Gly Thr Ala Arg Asp Arg Ser Gly Asp Lys Asp Leu 
            420                 425                 430         


Pro Ser Leu Ala Ala Leu Ser Ala Gly Pro Gly Val Gly Leu Cys Glu 
        435                 440                 445             


Glu His Gly Ser Pro Ala Ala Pro Gln His Leu Leu Gly Pro Gly Pro 
    450                 455                 460                 


Val Ala Gly Pro Lys Leu Tyr Pro Lys Leu Tyr Thr Asp Ile His Thr 
465                 470                 475                 480 


His Thr His Thr His Ser His Thr His Ser His Val Glu Gly Lys Val 
                485                 490                 495     


His Gln His Ile His Tyr Gln Cys 
            500                 


<210>  4849
<211>  845
<212>  PRT
<213>  Homo sapiens

<400>  4849

Met Gly Ser Trp Ala Leu Leu Trp Pro Pro Leu Leu Phe Thr Gly Leu 
1               5                   10                  15      


Leu Val Arg Pro Pro Gly Thr Met Ala Gln Ala Gln Tyr Cys Ser Val 
            20                  25                  30          


Asn Lys Asp Ile Phe Glu Val Glu Glu Asn Thr Asn Val Thr Glu Pro 
        35                  40                  45              


Leu Val Asp Ile His Val Pro Glu Gly Gln Glu Val Thr Leu Gly Ala 
    50                  55                  60                  


Leu Ser Thr Pro Phe Ala Phe Arg Ile Gln Gly Asn Gln Leu Phe Leu 
65                  70                  75                  80  


Asn Val Thr Pro Asp Tyr Glu Glu Lys Ser Leu Leu Glu Ala Gln Leu 
                85                  90                  95      


Leu Cys Gln Ser Gly Gly Thr Leu Val Thr Gln Leu Arg Val Phe Val 
            100                 105                 110         


Ser Val Leu Asp Val Asn Asp Asn Ala Pro Glu Phe Pro Phe Lys Thr 
        115                 120                 125             


Lys Glu Ile Arg Val Glu Glu Asp Thr Lys Val Asn Ser Thr Val Ile 
    130                 135                 140                 


Pro Glu Thr Gln Leu Gln Ala Glu Asp Arg Asp Lys Asp Asp Ile Leu 
145                 150                 155                 160 


Phe Tyr Thr Leu Gln Glu Met Thr Ala Gly Ala Ser Asp Tyr Phe Ser 
                165                 170                 175     


Leu Val Ser Val Asn Arg Pro Ala Leu Arg Leu Asp Arg Pro Leu Asp 
            180                 185                 190         


Phe Tyr Glu Arg Pro Asn Met Thr Phe Trp Leu Leu Val Arg Asp Thr 
        195                 200                 205             


Pro Gly Glu Asn Val Glu Pro Ser His Thr Ala Thr Ala Thr Leu Val 
    210                 215                 220                 


Leu Asn Val Val Pro Ala Asp Leu Arg Pro Pro Trp Phe Leu Pro Cys 
225                 230                 235                 240 


Thr Phe Ser Asp Gly Tyr Val Cys Ile Gln Ala Gln Tyr His Gly Ala 
                245                 250                 255     


Val Pro Thr Gly His Ile Leu Pro Ser Pro Leu Val Leu Arg Pro Gly 
            260                 265                 270         


Pro Ile Tyr Ala Glu Asp Gly Asp Arg Gly Ile Asn Gln Pro Ile Ile 
        275                 280                 285             


Tyr Ser Ile Phe Arg Gly Asn Val Asn Gly Thr Phe Ile Ile His Pro 
    290                 295                 300                 


Asp Ser Gly Asn Leu Thr Val Ala Arg Ser Val Pro Ser Pro Met Thr 
305                 310                 315                 320 


Phe Leu Leu Leu Val Lys Gly Gln Gln Ala Asp Leu Ala Arg Tyr Ser 
                325                 330                 335     


Val Thr Gln Val Thr Val Glu Ala Val Ala Ala Ala Gly Ser Pro Pro 
            340                 345                 350         


Arg Phe Pro Gln Arg Leu Tyr Arg Gly Thr Val Ala Arg Gly Ala Gly 
        355                 360                 365             


Ala Gly Val Val Val Lys Asp Ala Ala Ala Pro Ser Gln Pro Leu Arg 
    370                 375                 380                 


Ile Gln Ala Gln Asp Pro Glu Phe Ser Asp Leu Asn Ser Ala Ile Thr 
385                 390                 395                 400 


Tyr Arg Ile Thr Asn His Ser His Phe Arg Met Glu Gly Glu Val Val 
                405                 410                 415     


Leu Thr Thr Thr Thr Leu Ala Gln Ala Gly Ala Phe Tyr Ala Glu Val 
            420                 425                 430         


Glu Ala His Asn Thr Val Thr Ser Gly Thr Ala Thr Thr Val Ile Glu 
        435                 440                 445             


Ile Gln Val Ser Glu Gln Glu Pro Pro Ser Thr Asp Val Pro Pro Ser 
    450                 455                 460                 


Pro Glu Ala Gly Gly Thr Thr Gly Pro Trp Thr Ser Thr Thr Ser Glu 
465                 470                 475                 480 


Val Pro Arg Pro Pro Glu Pro Ser Gln Gly Pro Ser Thr Thr Ser Ser 
                485                 490                 495     


Gly Gly Gly Thr Gly Pro His Pro Pro Ser Gly Thr Thr Leu Arg Pro 
            500                 505                 510         


Pro Thr Ser Ser Thr Pro Gly Gly Pro Pro Gly Ala Glu Asn Ser Thr 
        515                 520                 525             


Ser His Gln Pro Ala Thr Pro Gly Gly Asp Thr Ala Gln Thr Pro Lys 
    530                 535                 540                 


Pro Gly Thr Ser Gln Pro Met Pro Pro Gly Val Gly Thr Ser Thr Ser 
545                 550                 555                 560 


His Gln Pro Ala Thr Pro Ser Gly Gly Thr Ala Gln Thr Pro Glu Pro 
                565                 570                 575     


Gly Thr Ser Gln Pro Met Pro Pro Ser Met Gly Thr Ser Thr Ser His 
            580                 585                 590         


Gln Pro Ala Thr Pro Gly Gly Gly Thr Ala Gln Thr Pro Glu Ala Gly 
        595                 600                 605             


Thr Ser Gln Pro Met Pro Pro Gly Met Gly Thr Ser Thr Ser His Gln 
    610                 615                 620                 


Pro Thr Thr Pro Gly Gly Gly Thr Ala Gln Thr Pro Glu Pro Gly Thr 
625                 630                 635                 640 


Ser Gln Pro Met Pro Leu Ser Lys Ser Thr Pro Ser Ser Gly Gly Gly 
                645                 650                 655     


Pro Ser Glu Asp Lys Arg Phe Ser Val Val Asp Met Ala Ala Leu Gly 
            660                 665                 670         


Gly Val Leu Gly Ala Leu Leu Leu Leu Ala Leu Leu Gly Leu Ala Val 
        675                 680                 685             


Leu Val His Lys His Tyr Gly Pro Arg Leu Lys Cys Cys Ser Gly Lys 
    690                 695                 700                 


Ala Pro Glu Pro Gln Pro Gln Gly Phe Asp Asn Gln Ala Phe Leu Pro 
705                 710                 715                 720 


Asp His Lys Ala Asn Trp Ala Pro Val Pro Ser Pro Thr His Asp Pro 
                725                 730                 735     


Lys Pro Ala Glu Ala Pro Met Pro Ala Glu Pro Ala Pro Pro Gly Pro 
            740                 745                 750         


Ala Ser Pro Gly Gly Ala Pro Glu Pro Pro Ala Ala Ala Arg Ala Gly 
        755                 760                 765             


Gly Ser Pro Thr Ala Val Arg Ser Ile Leu Thr Lys Glu Arg Arg Pro 
    770                 775                 780                 


Glu Gly Gly Tyr Lys Ala Val Trp Phe Gly Glu Asp Ile Gly Thr Glu 
785                 790                 795                 800 


Ala Asp Val Val Val Leu Asn Ala Pro Thr Leu Asp Val Asp Gly Ala 
                805                 810                 815     


Ser Asp Ser Gly Ser Gly Asp Glu Gly Glu Gly Ala Gly Arg Gly Gly 
            820                 825                 830         


Gly Pro Tyr Asp Ala Pro Gly Gly Asp Asp Ser Tyr Ile 
        835                 840                 845 


<210>  4850
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  4850

Met Phe Ser Thr Leu Arg Phe Phe Glu Gly Phe Cys Leu Ala Gly Ile 
1               5                   10                  15      


Ile Leu Thr Leu Tyr Ala Leu Arg Ile Glu Leu Cys Pro Pro Gly Lys 
            20                  25                  30          


Arg Phe Met Ile Thr Met Val Ala Ser Phe Val Ala Met Ala Gly Gln 
        35                  40                  45              


Phe Leu Met Pro Gly Leu Ala Ala Leu Cys Arg Asp Trp Gln Val Leu 
    50                  55                  60                  


Gln Ala Leu Ile Ile Cys Pro Phe Leu Leu Met Leu Leu Tyr Trp Ser 
65                  70                  75                  80  


Ile Phe Pro Glu Ser Leu Arg Trp Leu Met Ala Thr Gln Gln Phe Glu 
                85                  90                  95      


Ser Ala Lys Arg Leu Ile Leu His Phe Thr Gln Lys Asn Arg Met Asn 
            100                 105                 110         


Pro Glu Gly Asp Ile Lys Gly Val Ile Pro Glu Leu Glu Lys Glu Leu 
        115                 120                 125             


Ser Arg Arg Pro Lys Lys Val Cys Ile Val Lys Val Val Gly Thr Arg 
    130                 135                 140                 


Asn Leu Trp Lys Asn Ile Val Val Leu Cys Val Asn Ser Leu Thr Gly 
145                 150                 155                 160 


Tyr Gly Ile His His Cys Phe Ala Arg Ser Met Met Gly His Glu Val 
                165                 170                 175     


Lys Val Pro Leu Leu Glu Asn Phe Tyr Ala Asp Tyr Tyr Thr Thr Ala 
            180                 185                 190         


Ser Ile Ala Leu Val Ser Cys Leu Ala Met Cys Val Val Val Arg Phe 
        195                 200                 205             


Leu Gly Arg Arg Gly Gly Leu Leu Leu Phe Met Ile Leu Thr Ala Leu 
    210                 215                 220                 


Ala Ser Leu Leu Gln Leu Gly Leu Leu Asn Leu Ile Gly Lys Tyr Ser 
225                 230                 235                 240 


Gln His Pro Asp Ser Gly Met Ser Asp Ser Val Lys Asp Lys Phe Ser 
                245                 250                 255     


Ile Ala Phe Ser Ile Val Gly Met Phe Ala Ser His Ala Val Gly Ser 
            260                 265                 270         


Leu Ser Val Phe Phe Cys Ala Glu Ile Thr Pro Thr Val Ile Arg Cys 
        275                 280                 285             


Gly Gly Leu Gly Leu Val Leu Ala Ser Ala Gly Phe Gly Met Leu Thr 
    290                 295                 300                 


Ala Pro Ile Ile Glu Leu His Asn Gln Lys Gly Tyr Phe Leu His His 
305                 310                 315                 320 


Ile Ile Phe Ala Cys Cys Thr Leu Ile Cys Ile Ile Cys Ile Leu Leu 
                325                 330                 335     


Leu Pro Glu Ser Arg Asp Gln Asn Leu Pro Glu Asn Ile Ser Asn Gly 
            340                 345                 350         


Glu His Tyr Thr Arg Gln Pro Leu Leu Pro His Lys Lys Gly Glu Gln 
        355                 360                 365             


Pro Leu Leu Leu Thr Asn Ala Glu Leu Lys Asp Tyr Ser Gly Leu His 
    370                 375                 380                 


Asp Ala Ala Ala Ala Gly Asp Thr Leu Pro Glu Gly Ala Thr Ala Asn 
385                 390                 395                 400 


Gly Met Lys Ala Met 
                405 


<210>  4851
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  4851

Met Cys Ala Gln Tyr Cys Ile Ser Phe Ala Asp Val Glu Lys Ala His 
1               5                   10                  15      


Ile Asn Ile Arg Asp Ser Ile His Leu Thr Pro Val Leu Thr Ser Ser 
            20                  25                  30          


Ile Leu Asn Gln Leu Thr Gly Arg Asn Leu Phe Phe Lys Cys Glu Leu 
        35                  40                  45              


Phe Gln Lys Thr Gly Ser Phe Lys Ile Arg Gly Ala Leu Asn Ala Val 
    50                  55                  60                  


Arg Ser Leu Val Pro Asp Ala Leu Glu Arg Lys Pro Lys Ala Val Val 
65                  70                  75                  80  


Thr His Ser Ser Gly Asn His Gly Gln Ala Leu Thr Tyr Ala Ala Lys 
                85                  90                  95      


Leu Glu Gly Ile Pro Ala Tyr Ile Val Val Pro Gln Thr Ala Pro Asp 
            100                 105                 110         


Cys Lys Lys Leu Ala Ile Gln Ala Tyr Gly Ala Ser Ile Val Tyr Cys 
        115                 120                 125             


Glu Pro Ser Asp Glu Ser Arg Glu Asn Val Ala Lys Arg Val Thr Glu 
    130                 135                 140                 


Glu Thr Glu Gly Ile Met Val His Pro Asn Gln Glu Pro Ala Val Ile 
145                 150                 155                 160 


Ala Gly Gln Gly Thr Ile Ala Leu Glu Val Leu Asn Gln Val Pro Leu 
                165                 170                 175     


Val Asp Ala Leu Val Val Pro Val Gly Gly Gly Gly Met Leu Ala Gly 
            180                 185                 190         


Ile Ala Ile Thr Val Lys Ala Leu Lys Pro Ser Val Lys Val Tyr Ala 
        195                 200                 205             


Ala Glu Pro Ser Asn Ala Asp Asp Cys Tyr Gln Ser Lys Leu Lys Gly 
    210                 215                 220                 


Lys Leu Met Pro Asn Leu Tyr Pro Pro Glu Thr Ile Ala Asp Gly Val 
225                 230                 235                 240 


Lys Ser Ser Ile Gly Leu Asn Thr Trp Pro Ile Ile Arg Asp Leu Val 
                245                 250                 255     


Asp Asp Ile Phe Thr Val Thr Glu Asp Glu Ile Lys Cys Ala Thr Gln 
            260                 265                 270         


Leu Val Trp Glu Arg Met Lys Leu Leu Ile Glu Pro Thr Ala Gly Val 
        275                 280                 285             


Gly Val Ala Ala Val Leu Ser Gln His Phe Gln Thr Val Ser Pro Glu 
    290                 295                 300                 


Val Lys Asn Ile Cys Ile Val Leu Ser Gly Gly Asn Val Asp Leu Thr 
305                 310                 315                 320 


Ser Ser Ile Thr Trp Val Lys Gln Ala Glu Arg Pro Ala Ser Tyr Gln 
                325                 330                 335     


Ser Val Ser Val 
            340 


<210>  4852
<211>  1173
<212>  PRT
<213>  Homo sapiens

<400>  4852

Met Gly Asp Met Ala Asn Ser Ser Ile Glu Phe His Pro Lys Pro Gln 
1               5                   10                  15      


Gln Gln Arg Asp Val Pro Gln Ala Gly Gly Phe Gly Cys Thr Leu Ala 
            20                  25                  30          


Glu Leu Arg Thr Leu Met Glu Leu Arg Gly Ala Glu Ala Leu Gln Lys 
        35                  40                  45              


Ile Glu Glu Ala Tyr Gly Asp Val Ser Gly Leu Cys Arg Arg Leu Lys 
    50                  55                  60                  


Thr Ser Pro Thr Glu Gly Leu Ala Asp Asn Thr Asn Asp Leu Glu Lys 
65                  70                  75                  80  


Arg Arg Gln Ile Tyr Gly Gln Asn Phe Ile Pro Pro Lys Gln Pro Lys 
                85                  90                  95      


Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile 
            100                 105                 110         


Ile Leu Glu Val Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Ala 
        115                 120                 125             


Pro Pro Gly Glu Glu Ser Glu Ala Cys Gly Asn Val Ser Gly Gly Ala 
    130                 135                 140                 


Glu Asp Glu Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile 
145                 150                 155                 160 


Leu Leu Ser Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp 
                165                 170                 175     


Ser Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu 
            180                 185                 190         


Gln Lys Phe Thr Val Ile Arg Asn Gly Gln Leu Leu Gln Val Pro Val 
        195                 200                 205             


Ala Ala Leu Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu 
    210                 215                 220                 


Leu Pro Ala Asp Gly Val Leu Ile Gln Ala Asn Asp Leu Lys Ile Asp 
225                 230                 235                 240 


Glu Ser Ser Leu Thr Gly Glu Ser Asp His Val Arg Lys Ser Ala Asp 
                245                 250                 255     


Lys Asp Pro Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly 
            260                 265                 270         


Arg Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile 
        275                 280                 285             


Phe Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys 
    290                 295                 300                 


Lys Gly Lys Gln Gln Asp Gly Ala Met Glu Ser Ser Gln Thr Lys Ala 
305                 310                 315                 320 


Lys Lys Gln Asp Gly Ala Val Ala Met Glu Met Gln Pro Leu Lys Ser 
                325                 330                 335     


Ala Glu Gly Gly Glu Met Glu Glu Arg Glu Lys Lys Lys Ala Asn Ala 
            340                 345                 350         


Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys Leu Ala 
        355                 360                 365             


Val Gln Ile Gly Lys Ala Gly Leu Val Met Ser Ala Ile Thr Val Ile 
    370                 375                 380                 


Ile Leu Val Leu Tyr Phe Val Ile Glu Thr Phe Val Val Glu Gly Arg 
385                 390                 395                 400 


Thr Trp Leu Ala Glu Cys Thr Pro Val Tyr Val Gln Tyr Phe Val Lys 
                405                 410                 415     


Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro Glu Gly 
            420                 425                 430         


Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys Lys Met 
        435                 440                 445             


Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu Thr Met 
    450                 455                 460                 


Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr 
465                 470                 475                 480 


Asn Arg Met Thr Val Val Gln Ser Tyr Leu Gly Asp Thr His Tyr Lys 
                485                 490                 495     


Glu Ile Pro Ala Pro Ser Ala Leu Thr Pro Lys Ile Leu Asp Leu Leu 
            500                 505                 510         


Val His Ala Ile Ser Ile Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro 
        515                 520                 525             


Pro Glu Lys Glu Gly Ala Leu Pro Arg Gln Val Gly Asn Lys Thr Glu 
    530                 535                 540                 


Cys Ala Leu Leu Gly Phe Val Leu Asp Leu Lys Arg Asp Phe Gln Pro 
545                 550                 555                 560 


Val Arg Glu Gln Ile Pro Glu Asp Lys Leu Tyr Lys Val Tyr Thr Phe 
                565                 570                 575     


Asn Ser Val Arg Lys Ser Met Ser Thr Val Ile Arg Met Pro Asp Gly 
            580                 585                 590         


Gly Phe Arg Leu Phe Ser Lys Gly Ala Ser Glu Ile Leu Leu Lys Lys 
        595                 600                 605             


Cys Thr Asn Ile Leu Asn Ser Asn Gly Glu Leu Arg Gly Phe Arg Pro 
    610                 615                 620                 


Arg Asp Arg Asp Asp Met Val Arg Lys Ile Ile Glu Pro Met Ala Cys 
625                 630                 635                 640 


Asp Gly Leu Arg Thr Ile Cys Ile Ala Tyr Arg Asp Phe Ser Ala Gly 
                645                 650                 655     


Gln Glu Pro Asp Trp Asp Asn Glu Asn Glu Val Val Gly Asp Leu Thr 
            660                 665                 670         


Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro Glu Val Pro 
        675                 680                 685             


Glu Ala Ile Arg Lys Cys Gln Arg Ala Gly Ile Thr Val Arg Met Val 
    690                 695                 700                 


Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Ala Lys Cys Gly 
705                 710                 715                 720 


Ile Ile Gln Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe 
                725                 730                 735     


Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln Glu Arg Leu 
            740                 745                 750         


Asp Lys Val Trp Pro Lys Leu Arg Val Leu Ala Arg Ser Ser Pro Thr 
        755                 760                 765             


Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr Thr Gly Glu 
    770                 775                 780                 


Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn Asp Gly Pro 
785                 790                 795                 800 


Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile Ala Gly Thr 
                805                 810                 815     


Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe 
            820                 825                 830         


Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val Tyr Asp Ser 
        835                 840                 845             


Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val Val Ala Val 
    850                 855                 860                 


Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys 
865                 870                 875                 880 


Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr Phe Ala Ser 
                885                 890                 895     


Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu Leu Arg Lys 
            900                 905                 910         


Pro Tyr Gly Arg Asp Lys Pro Leu Ile Ser Arg Thr Met Met Lys Asn 
        915                 920                 925             


Ile Leu Gly His Ala Val Tyr Gln Leu Ala Ile Ile Phe Thr Leu Leu 
    930                 935                 940                 


Phe Val Gly Glu Leu Phe Phe Asp Ile Asp Ser Gly Arg Asn Ala Pro 
945                 950                 955                 960 


Leu His Ser Pro Pro Ser Glu His Tyr Thr Ile Ile Phe Asn Thr Phe 
                965                 970                 975     


Val Met Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys Ile His Gly 
            980                 985                 990         


Glu Arg Asn Val Phe Asp Gly Ile  Phe Ser Asn Pro Ile  Phe Cys Thr 
        995                 1000                 1005             


Ile Val  Leu Gly Thr Phe Gly  Ile Gln Ile Val Ile  Val Gln Phe 
    1010                 1015                 1020             


Gly Gly  Lys Pro Phe Ser Cys  Ser Pro Leu Ser Thr  Glu Gln Trp 
    1025                 1030                 1035             


Leu Trp  Cys Leu Phe Val Gly  Val Gly Glu Leu Val  Trp Gly Gln 
    1040                 1045                 1050             


Val Ile  Ala Thr Ile Pro Thr  Ser Gln Leu Lys Cys  Leu Lys Glu 
    1055                 1060                 1065             


Ala Gly  His Gly Pro Gly Lys  Asp Glu Met Thr Asp  Glu Glu Leu 
    1070                 1075                 1080             


Ala Glu  Gly Glu Glu Glu Ile  Asp His Ala Glu Arg  Glu Leu Arg 
    1085                 1090                 1095             


Arg Gly  Gln Ile Leu Trp Phe  Arg Gly Leu Asn Arg  Ile Gln Thr 
    1100                 1105                 1110             


Gln Met  Glu Val Val Ser Thr  Phe Lys Arg Ser Gly  Ser Val Gln 
    1115                 1120                 1125             


Gly Ala  Val Arg Arg Arg Ser  Ser Val Leu Ser Gln  Leu His Asp 
    1130                 1135                 1140             


Val Thr  Asn Leu Ser Thr Pro  Thr His Ala Ile Leu  Ser Ala Ala 
    1145                 1150                 1155             


Asn Pro  Thr Ser Ala Ala Gly  Asn Pro Gly Gly Glu  Ser Val Pro 
    1160                 1165                 1170             


<210>  4853
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  4853

Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro 
1               5                   10                  15      


Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg 
            20                  25                  30          


Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu 
        35                  40                  45              


Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile 
    50                  55                  60                  


Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile 
65                  70                  75                  80  


Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile 
                85                  90                  95      


Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu 
            100                 105                 110         


Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile 
        115                 120                 125             


Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser 
    130                 135                 140                 


His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro 
145                 150                 155                 160 


Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn 
                165                 170                 175     


Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly 
            180                 185                 190         


Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile 
        195                 200                 205             


Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys 
    210                 215                 220                 


Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile 
225                 230                 235                 240 


Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro 
                245                 250                 255     


Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu 
            260                 265                 270         


Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser 
        275                 280                 285             


Ser Pro Ile Glu Asn Asp Ser Ser Pro 
    290                 295         


<210>  4854
<211>  435
<212>  PRT
<213>  Homo sapiens

<400>  4854

Met Gly Asp Trp Ser Phe Leu Gly Arg Leu Leu Glu Asn Ala Gln Glu 
1               5                   10                  15      


His Ser Thr Val Ile Gly Lys Val Trp Leu Thr Val Leu Phe Ile Phe 
            20                  25                  30          


Arg Ile Leu Val Leu Gly Ala Ala Ala Glu Asp Val Trp Gly Asp Glu 
        35                  40                  45              


Gln Ser Asp Phe Thr Cys Asn Thr Gln Gln Pro Gly Cys Glu Asn Val 
    50                  55                  60                  


Cys Tyr Asp Arg Ala Phe Pro Ile Ser His Ile Arg Phe Trp Ala Leu 
65                  70                  75                  80  


Gln Ile Ile Phe Val Ser Thr Pro Thr Leu Ile Tyr Leu Gly His Val 
                85                  90                  95      


Leu His Ile Val Arg Met Glu Glu Lys Lys Lys Glu Arg Glu Glu Glu 
            100                 105                 110         


Glu Gln Leu Lys Arg Glu Ser Pro Ser Pro Lys Glu Pro Pro Gln Asp 
        115                 120                 125             


Asn Pro Ser Ser Arg Asp Asp Arg Gly Arg Val Arg Met Ala Gly Ala 
    130                 135                 140                 


Leu Leu Arg Thr Tyr Val Phe Asn Ile Ile Phe Lys Thr Leu Phe Glu 
145                 150                 155                 160 


Val Gly Phe Ile Ala Gly Gln Tyr Phe Leu Tyr Gly Phe Glu Leu Lys 
                165                 170                 175     


Pro Leu Tyr Arg Cys Asp Arg Trp Pro Cys Pro Asn Thr Val Asp Cys 
            180                 185                 190         


Phe Ile Ser Arg Pro Thr Glu Lys Thr Ile Phe Ile Ile Phe Met Leu 
        195                 200                 205             


Ala Val Ala Cys Ala Ser Leu Leu Leu Asn Met Leu Glu Ile Tyr His 
    210                 215                 220                 


Leu Gly Trp Lys Lys Leu Lys Gln Gly Val Thr Ser Arg Leu Gly Pro 
225                 230                 235                 240 


Asp Ala Ser Glu Ala Pro Leu Gly Thr Ala Asp Pro Pro Pro Leu Pro 
                245                 250                 255     


Pro Ser Ser Arg Pro Pro Ala Val Ala Ile Gly Phe Pro Pro Tyr Tyr 
            260                 265                 270         


Ala His Thr Ala Ala Pro Leu Gly Gln Ala Arg Ala Val Gly Tyr Pro 
        275                 280                 285             


Gly Ala Pro Pro Pro Ala Ala Asp Phe Lys Leu Leu Ala Leu Thr Glu 
    290                 295                 300                 


Ala Arg Gly Lys Gly Gln Ser Ala Lys Leu Tyr Asn Gly His His His 
305                 310                 315                 320 


Leu Leu Met Thr Glu Gln Asn Trp Ala Asn Gln Ala Ala Glu Arg Gln 
                325                 330                 335     


Pro Pro Ala Leu Lys Ala Tyr Pro Ala Ala Ser Thr Pro Ala Ala Pro 
            340                 345                 350         


Ser Pro Val Gly Ser Ser Ser Pro Pro Leu Ala His Glu Ala Glu Ala 
        355                 360                 365             


Gly Ala Ala Pro Leu Leu Leu Asp Gly Ser Gly Ser Ser Leu Glu Gly 
    370                 375                 380                 


Ser Ala Leu Ala Gly Thr Pro Glu Glu Glu Glu Gln Ala Val Thr Thr 
385                 390                 395                 400 


Ala Ala Gln Met His Gln Pro Pro Leu Pro Leu Gly Asp Pro Gly Arg 
                405                 410                 415     


Ala Ser Lys Ala Ser Arg Ala Ser Ser Gly Arg Ala Arg Pro Glu Asp 
            420                 425                 430         


Leu Ala Ile 
        435 


<210>  4855
<211>  908
<212>  PRT
<213>  Homo sapiens

<400>  4855

Met Lys Ile Ile Phe Pro Ile Leu Ser Asn Pro Val Phe Arg Arg Thr 
1               5                   10                  15      


Val Lys Leu Leu Leu Cys Leu Leu Trp Ile Gly Tyr Ser Gln Gly Thr 
            20                  25                  30          


Thr His Val Leu Arg Phe Gly Gly Ile Phe Glu Tyr Val Glu Ser Gly 
        35                  40                  45              


Pro Met Gly Ala Glu Glu Leu Ala Phe Arg Phe Ala Val Asn Thr Ile 
    50                  55                  60                  


Asn Arg Asn Arg Thr Leu Leu Pro Asn Thr Thr Leu Thr Tyr Asp Thr 
65                  70                  75                  80  


Gln Lys Ile Asn Leu Tyr Asp Ser Phe Glu Ala Ser Lys Lys Ala Cys 
                85                  90                  95      


Asp Gln Leu Ser Leu Gly Val Ala Ala Ile Phe Gly Pro Ser His Ser 
            100                 105                 110         


Ser Ser Ala Asn Ala Val Gln Ser Ile Cys Asn Ala Leu Gly Val Pro 
        115                 120                 125             


His Ile Gln Thr Arg Trp Lys His Gln Val Ser Asp Asn Lys Asp Ser 
    130                 135                 140                 


Phe Tyr Val Ser Leu Tyr Pro Asp Phe Ser Ser Leu Ser Arg Ala Ile 
145                 150                 155                 160 


Leu Asp Leu Val Gln Phe Phe Lys Trp Lys Thr Val Thr Val Val Tyr 
                165                 170                 175     


Asp Asp Ser Thr Gly Leu Ile Arg Leu Gln Glu Leu Ile Lys Ala Pro 
            180                 185                 190         


Ser Arg Tyr Asn Leu Arg Leu Lys Ile Arg Gln Leu Pro Ala Asp Thr 
        195                 200                 205             


Lys Asp Ala Lys Pro Leu Leu Lys Glu Met Lys Arg Gly Lys Glu Phe 
    210                 215                 220                 


His Val Ile Phe Asp Cys Ser His Glu Met Ala Ala Gly Ile Leu Lys 
225                 230                 235                 240 


Gln Ala Leu Ala Met Gly Met Met Thr Glu Tyr Tyr His Tyr Ile Phe 
                245                 250                 255     


Thr Thr Leu Asp Leu Phe Ala Leu Asp Val Glu Pro Tyr Arg Tyr Ser 
            260                 265                 270         


Gly Val Asn Met Thr Gly Phe Arg Ile Leu Asn Thr Glu Asn Thr Gln 
        275                 280                 285             


Val Ser Ser Ile Ile Glu Lys Trp Ser Met Glu Arg Leu Gln Ala Pro 
    290                 295                 300                 


Pro Lys Pro Asp Ser Gly Leu Leu Asp Gly Phe Met Thr Thr Asp Ala 
305                 310                 315                 320 


Ala Leu Met Tyr Asp Ala Val His Val Val Ser Val Ala Val Gln Gln 
                325                 330                 335     


Phe Pro Gln Met Thr Val Ser Ser Leu Gln Cys Asn Arg His Lys Pro 
            340                 345                 350         


Trp Arg Phe Gly Thr Arg Phe Met Ser Leu Ile Lys Glu Ala His Trp 
        355                 360                 365             


Glu Gly Leu Thr Gly Arg Ile Thr Phe Asn Lys Thr Asn Gly Leu Arg 
    370                 375                 380                 


Thr Asp Phe Asp Leu Asp Val Ile Ser Leu Lys Glu Glu Gly Leu Glu 
385                 390                 395                 400 


Lys Ile Gly Thr Trp Asp Pro Ala Ser Gly Leu Asn Met Thr Glu Ser 
                405                 410                 415     


Gln Lys Gly Lys Pro Ala Asn Ile Thr Asp Ser Leu Ser Asn Arg Ser 
            420                 425                 430         


Leu Ile Val Thr Thr Ile Leu Glu Glu Pro Tyr Val Leu Phe Lys Lys 
        435                 440                 445             


Ser Asp Lys Pro Leu Tyr Gly Asn Asp Arg Phe Glu Gly Tyr Cys Ile 
    450                 455                 460                 


Asp Leu Leu Arg Glu Leu Ser Thr Ile Leu Gly Phe Thr Tyr Glu Ile 
465                 470                 475                 480 


Arg Leu Val Glu Asp Gly Lys Tyr Gly Ala Gln Asp Asp Ala Asn Gly 
                485                 490                 495     


Gln Trp Asn Gly Met Val Arg Glu Leu Ile Asp His Lys Ala Asp Leu 
            500                 505                 510         


Ala Val Ala Pro Leu Ala Ile Thr Tyr Val Arg Glu Lys Val Ile Asp 
        515                 520                 525             


Phe Ser Lys Pro Phe Met Thr Leu Gly Ile Ser Ile Leu Tyr Arg Lys 
    530                 535                 540                 


Pro Asn Gly Thr Asn Pro Gly Val Phe Ser Phe Leu Asn Pro Leu Ser 
545                 550                 555                 560 


Pro Asp Ile Trp Met Tyr Ile Leu Leu Ala Tyr Leu Gly Val Ser Cys 
                565                 570                 575     


Val Leu Phe Val Ile Ala Arg Phe Ser Pro Tyr Glu Trp Tyr Asn Pro 
            580                 585                 590         


His Pro Cys Asn Pro Asp Ser Asp Val Val Glu Asn Asn Phe Thr Leu 
        595                 600                 605             


Leu Asn Ser Phe Trp Phe Gly Val Gly Ala Leu Met Gln Gln Gly Ser 
    610                 615                 620                 


Glu Leu Met Pro Lys Ala Leu Ser Thr Arg Ile Val Gly Gly Ile Trp 
625                 630                 635                 640 


Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala 
                645                 650                 655     


Ala Phe Leu Thr Val Glu Arg Met Glu Ser Pro Ile Asp Ser Ala Asp 
            660                 665                 670         


Asp Leu Ala Lys Gln Thr Lys Ile Glu Tyr Gly Ala Val Glu Asp Gly 
        675                 680                 685             


Ala Thr Met Thr Phe Phe Lys Lys Ser Lys Ile Ser Thr Tyr Asp Lys 
    690                 695                 700                 


Met Trp Ala Phe Met Ser Ser Arg Arg Gln Ser Val Leu Val Lys Ser 
705                 710                 715                 720 


Asn Glu Glu Gly Ile Gln Arg Val Leu Thr Ser Asp Tyr Ala Phe Leu 
                725                 730                 735     


Met Glu Ser Thr Thr Ile Glu Phe Val Thr Gln Arg Asn Cys Asn Leu 
            740                 745                 750         


Thr Gln Ile Gly Gly Leu Ile Asp Ser Lys Gly Tyr Gly Val Gly Thr 
        755                 760                 765             


Pro Met Gly Ser Pro Tyr Arg Asp Lys Ile Thr Ile Ala Ile Leu Gln 
    770                 775                 780                 


Leu Gln Glu Glu Gly Lys Leu His Met Met Lys Glu Lys Trp Trp Arg 
785                 790                 795                 800 


Gly Asn Gly Cys Pro Glu Glu Glu Ser Lys Glu Ala Ser Ala Leu Gly 
                805                 810                 815     


Val Gln Asn Ile Gly Gly Ile Phe Ile Val Leu Ala Ala Gly Leu Val 
            820                 825                 830         


Leu Ser Val Phe Val Ala Val Gly Glu Phe Leu Tyr Lys Ser Lys Lys 
        835                 840                 845             


Asn Ala Gln Leu Glu Lys Arg Ser Phe Cys Ser Ala Met Val Glu Glu 
    850                 855                 860                 


Leu Arg Met Ser Leu Lys Cys Gln Arg Arg Leu Lys His Lys Pro Gln 
865                 870                 875                 880 


Ala Pro Val Ile Val Lys Thr Glu Glu Val Ile Asn Met His Thr Phe 
                885                 890                 895     


Asn Asp Arg Arg Leu Pro Gly Lys Glu Thr Met Ala 
            900                 905             


<210>  4856
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  4856

Met Phe Gly Leu Lys Arg Asn Ala Val Ile Gly Leu Asn Leu Tyr Cys 
1               5                   10                  15      


Gly Gly Ala Gly Leu Gly Ala Gly Ser Gly Gly Ala Thr Arg Pro Gly 
            20                  25                  30          


Gly Arg Leu Leu Ala Thr Glu Lys Glu Ala Ser Ala Arg Arg Glu Ile 
        35                  40                  45              


Gly Gly Gly Glu Ala Gly Ala Val Ile Gly Gly Ser Ala Gly Ala Ser 
    50                  55                  60                  


Pro Pro Ser Thr Leu Thr Pro Asp Ser Arg Arg Val Ala Arg Pro Pro 
65                  70                  75                  80  


Pro Ile Gly Ala Glu Val Pro Asp Val Thr Ala Thr Pro Ala Arg Leu 
                85                  90                  95      


Leu Phe Phe Ala Pro Thr Arg Arg Ala Ala Pro Leu Glu Glu Met Glu 
            100                 105                 110         


Ala Pro Ala Ala Asp Ala Ile Met Ser Pro Glu Glu Glu Leu Asp Gly 
        115                 120                 125             


Tyr Glu Pro Glu Pro Leu Gly Lys Arg Pro Ala Val Leu Pro Leu Leu 
    130                 135                 140                 


Glu Leu Val Gly Glu Ser Gly Asn Asn Thr Ser Thr Asp Gly Ser Leu 
145                 150                 155                 160 


Pro Ser Thr Pro Pro Pro Ala Glu Glu Glu Glu Asp Glu Leu Tyr Arg 
                165                 170                 175     


Gln Ser Leu Glu Ile Ile Ser Arg Tyr Leu Arg Glu Gln Ala Thr Gly 
            180                 185                 190         


Ala Lys Asp Thr Lys Pro Met Gly Arg Ser Gly Ala Thr Ser Arg Lys 
        195                 200                 205             


Ala Leu Glu Thr Leu Arg Arg Val Gly Asp Gly Val Gln Arg Asn His 
    210                 215                 220                 


Glu Thr Ala Phe Gln Gly Met Leu Arg Lys Leu Asp Ile Lys Asn Glu 
225                 230                 235                 240 


Asp Asp Val Lys Ser Leu Ser Arg Val Met Ile His Val Phe Ser Asp 
                245                 250                 255     


Gly Val Thr Asn Trp Gly Arg Ile Val Thr Leu Ile Ser Phe Gly Ala 
            260                 265                 270         


Phe Val Ala Lys His Leu Lys Thr Ile Asn Gln Glu Ser Cys Ile Glu 
        275                 280                 285             


Pro Leu Ala Glu Ser Ile Thr Asp Val Leu Val Arg Thr Lys Arg Asp 
    290                 295                 300                 


Trp Leu Val Lys Gln Arg Gly Trp Asp Gly Phe Val Glu Phe Phe His 
305                 310                 315                 320 


Val Glu Asp Leu Glu Gly Gly Ile Arg Asn Val Leu Leu Ala Phe Ala 
                325                 330                 335     


Gly Val Ala Gly Val Gly Ala Gly Leu Ala Tyr Leu Ile Arg 
            340                 345                 350 


<210>  4857
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  4857

Met Pro Ser Phe Asp Glu Ala Leu Gln Arg Val Gly Glu Phe Gly Arg 
1               5                   10                  15      


Phe Gln Arg Arg Val Phe Leu Leu Leu Cys Leu Thr Gly Val Thr Phe 
            20                  25                  30          


Ala Phe Leu Phe Val Gly Val Val Phe Leu Gly Thr Gln Pro Asp His 
        35                  40                  45              


Tyr Trp Cys Arg Gly Pro Ser Ala Ala Ala Leu Ala Glu Arg Cys Gly 
    50                  55                  60                  


Trp Ser Pro Glu Glu Glu Trp Asn Arg Thr Ala Pro Ala Ser Arg Gly 
65                  70                  75                  80  


Pro Glu Pro Pro Glu Arg Arg Gly Arg Cys Gln Arg Tyr Leu Leu Glu 
                85                  90                  95      


Ala Ala Asn Asp Ser Ala Ser Ala Thr Ser Ala Leu Ser Cys Ala Asp 
            100                 105                 110         


Pro Leu Ala Ala Phe Pro Asn Arg Ser Ala Pro Leu Val Pro Cys Arg 
        115                 120                 125             


Gly Gly Trp Arg Tyr Ala Gln Ala His Ser Thr Ile Val Ser Glu Phe 
    130                 135                 140                 


Asp Leu Val Cys Val Asn Ala Trp Met Leu Asp Leu Thr Gln Ala Ile 
145                 150                 155                 160 


Leu Asn Leu Gly Phe Leu Thr Gly Ala Phe Thr Leu Gly Tyr Ala Ala 
                165                 170                 175     


Asp Arg Tyr Gly Arg Ile Val Ile Tyr Leu Leu Ser Cys Leu Gly Val 
            180                 185                 190         


Gly Val Thr Gly Val Val Val Ala Phe Ala Pro Asn Phe Pro Val Phe 
        195                 200                 205             


Val Ile Phe Arg Phe Leu Gln Gly Val Phe Gly Lys Gly Thr Trp Met 
    210                 215                 220                 


Thr Cys Tyr Val Ile Val Thr Glu Ile Val Gly Ser Lys Gln Arg Arg 
225                 230                 235                 240 


Ile Val Gly Ile Val Ile Gln Met Phe Phe Thr Leu Gly Ile Ile Ile 
                245                 250                 255     


Leu Pro Gly Ile Ala Tyr Phe Ile Pro Asn Trp Gln Gly Ile Gln Leu 
            260                 265                 270         


Ala Ile Thr Leu Pro Ser Phe Leu Phe Leu Leu Tyr Tyr Trp Val Val 
        275                 280                 285             


Pro Glu Ser Pro Arg Trp Leu Ile Thr Arg Lys Lys Gly Asp Lys Ala 
    290                 295                 300                 


Leu Gln Ile Leu Arg Arg Ile Ala Lys Cys Asn Gly Lys Tyr Leu Ser 
305                 310                 315                 320 


Ser Asn Tyr Ser Glu Ile Thr Val Thr Asp Glu Glu Val Ser Asn Pro 
                325                 330                 335     


Ser Phe Leu Asp Leu Val Arg Thr Pro Gln Met Arg Lys Cys Thr Leu 
            340                 345                 350         


Ile Leu Met Phe Ala Trp Phe Thr Ser Ala Val Val Tyr Gln Gly Leu 
        355                 360                 365             


Val Met Arg Leu Gly Ile Ile Gly Gly Asn Leu Tyr Ile Asp Phe Phe 
    370                 375                 380                 


Ile Ser Gly Val Val Glu Leu Pro Gly Ala Leu Leu Ile Leu Leu Thr 
385                 390                 395                 400 


Ile Glu Arg Leu Gly Arg Arg Leu Pro Phe Ala Ala Ser Asn Ile Val 
                405                 410                 415     


Ala Gly Val Ala Cys Leu Val Thr Ala Phe Leu Pro Glu Gly Ile Ala 
            420                 425                 430         


Trp Leu Arg Thr Thr Val Ala Thr Leu Gly Arg Leu Gly Ile Thr Met 
        435                 440                 445             


Ala Phe Glu Ile Val Tyr Leu Val Asn Ser Glu Leu Tyr Pro Thr Thr 
    450                 455                 460                 


Leu Arg Asn Phe Gly Val Ser Leu Cys Ser Gly Leu Cys Asp Phe Gly 
465                 470                 475                 480 


Gly Ile Ile Ala Pro Phe Leu Leu Phe Arg Leu Ala Ala Val Trp Leu 
                485                 490                 495     


Glu Leu Pro Leu Ile Ile Phe Gly Ile Leu Ala Ser Ile Cys Gly Gly 
            500                 505                 510         


Leu Val Met Leu Leu Pro Glu Thr Lys Gly Ile Ala Leu Pro Glu Thr 
        515                 520                 525             


Val Asp Asp Val Glu Lys Leu Gly Ser Pro His Ser Cys Lys Cys Gly 
    530                 535                 540                 


Arg Asn Lys Lys Thr Pro Val Ser Arg Ser His Leu 
545                 550                 555     


<210>  4858
<211>  855
<212>  PRT
<213>  Homo sapiens

<400>  4858

Met Gly Ser Asp Arg Ala Arg Lys Gly Gly Gly Gly Pro Lys Asp Phe 
1               5                   10                  15      


Gly Ala Gly Leu Lys Tyr Asn Ser Arg His Glu Lys Val Asn Gly Leu 
            20                  25                  30          


Glu Glu Gly Val Glu Phe Leu Pro Val Asn Asn Val Lys Lys Val Glu 
        35                  40                  45              


Lys His Gly Pro Gly Arg Trp Val Val Leu Ala Ala Val Leu Ile Gly 
    50                  55                  60                  


Leu Leu Leu Val Leu Leu Gly Ile Gly Phe Leu Val Trp His Leu Gln 
65                  70                  75                  80  


Tyr Arg Asp Val Arg Val Gln Lys Val Phe Asn Gly Tyr Met Arg Ile 
                85                  90                  95      


Thr Asn Glu Asn Phe Val Asp Ala Tyr Glu Asn Ser Asn Ser Thr Glu 
            100                 105                 110         


Phe Val Ser Leu Ala Ser Lys Val Lys Asp Ala Leu Lys Leu Leu Tyr 
        115                 120                 125             


Ser Gly Val Pro Phe Leu Gly Pro Tyr His Lys Glu Ser Ala Val Thr 
    130                 135                 140                 


Ala Phe Ser Glu Gly Ser Val Ile Ala Tyr Tyr Trp Ser Glu Phe Ser 
145                 150                 155                 160 


Ile Pro Gln His Leu Val Glu Glu Ala Glu Arg Val Met Ala Glu Glu 
                165                 170                 175     


Arg Val Val Met Leu Pro Pro Arg Ala Arg Ser Leu Lys Ser Phe Val 
            180                 185                 190         


Val Thr Ser Val Val Ala Phe Pro Thr Asp Ser Lys Thr Val Gln Arg 
        195                 200                 205             


Thr Gln Asp Asn Ser Cys Ser Phe Gly Leu His Ala Arg Gly Val Glu 
    210                 215                 220                 


Leu Met Arg Phe Thr Thr Pro Gly Phe Pro Asp Ser Pro Tyr Pro Ala 
225                 230                 235                 240 


His Ala Arg Cys Gln Trp Ala Leu Arg Gly Asp Ala Asp Ser Val Leu 
                245                 250                 255     


Ser Leu Thr Phe Arg Ser Phe Asp Leu Ala Ser Cys Asp Glu Arg Gly 
            260                 265                 270         


Ser Asp Leu Val Thr Val Tyr Asn Thr Leu Ser Pro Met Glu Pro His 
        275                 280                 285             


Ala Leu Val Gln Leu Cys Gly Thr Tyr Pro Pro Ser Tyr Asn Leu Thr 
    290                 295                 300                 


Phe His Ser Ser Gln Asn Val Leu Leu Ile Thr Leu Ile Thr Asn Thr 
305                 310                 315                 320 


Glu Arg Arg His Pro Gly Phe Glu Ala Thr Phe Phe Gln Leu Pro Arg 
                325                 330                 335     


Met Ser Ser Cys Gly Gly Arg Leu Arg Lys Ala Gln Gly Thr Phe Asn 
            340                 345                 350         


Ser Pro Tyr Tyr Pro Gly His Tyr Pro Pro Asn Ile Asp Cys Thr Trp 
        355                 360                 365             


Asn Ile Glu Val Pro Asn Asn Gln His Val Lys Val Arg Phe Lys Phe 
    370                 375                 380                 


Phe Tyr Leu Leu Glu Pro Gly Val Pro Ala Gly Thr Cys Pro Lys Asp 
385                 390                 395                 400 


Tyr Val Glu Ile Asn Gly Glu Lys Tyr Cys Gly Glu Arg Ser Gln Phe 
                405                 410                 415     


Val Val Thr Ser Asn Ser Asn Lys Ile Thr Val Arg Phe His Ser Asp 
            420                 425                 430         


Gln Ser Tyr Thr Asp Thr Gly Phe Leu Ala Glu Tyr Leu Ser Tyr Asp 
        435                 440                 445             


Ser Ser Asp Pro Cys Pro Gly Gln Phe Thr Cys Arg Thr Gly Arg Cys 
    450                 455                 460                 


Ile Arg Lys Glu Leu Arg Cys Asp Gly Trp Ala Asp Cys Thr Asp His 
465                 470                 475                 480 


Ser Asp Glu Leu Asn Cys Ser Cys Asp Ala Gly His Gln Phe Thr Cys 
                485                 490                 495     


Lys Asn Lys Phe Cys Lys Pro Leu Phe Trp Val Cys Asp Ser Val Asn 
            500                 505                 510         


Asp Cys Gly Asp Asn Ser Asp Glu Gln Gly Cys Ser Cys Pro Ala Gln 
        515                 520                 525             


Thr Phe Arg Cys Ser Asn Gly Lys Cys Leu Ser Lys Ser Gln Gln Cys 
    530                 535                 540                 


Asn Gly Lys Asp Asp Cys Gly Asp Gly Ser Asp Glu Ala Ser Cys Pro 
545                 550                 555                 560 


Lys Val Asn Val Val Thr Cys Thr Lys His Thr Tyr Arg Cys Leu Asn 
                565                 570                 575     


Gly Leu Cys Leu Ser Lys Gly Asn Pro Glu Cys Asp Gly Lys Glu Asp 
            580                 585                 590         


Cys Ser Asp Gly Ser Asp Glu Lys Asp Cys Asp Cys Gly Leu Arg Ser 
        595                 600                 605             


Phe Thr Arg Gln Ala Arg Val Val Gly Gly Thr Asp Ala Asp Glu Gly 
    610                 615                 620                 


Glu Trp Pro Trp Gln Val Ser Leu His Ala Leu Gly Gln Gly His Ile 
625                 630                 635                 640 


Cys Gly Ala Ser Leu Ile Ser Pro Asn Trp Leu Val Ser Ala Ala His 
                645                 650                 655     


Cys Tyr Ile Asp Asp Arg Gly Phe Arg Tyr Ser Asp Pro Thr Gln Trp 
            660                 665                 670         


Thr Ala Phe Leu Gly Leu His Asp Gln Ser Gln Arg Ser Ala Pro Gly 
        675                 680                 685             


Val Gln Glu Arg Arg Leu Lys Arg Ile Ile Ser His Pro Phe Phe Asn 
    690                 695                 700                 


Asp Phe Thr Phe Asp Tyr Asp Ile Ala Leu Leu Glu Leu Glu Lys Pro 
705                 710                 715                 720 


Ala Glu Tyr Ser Ser Met Val Arg Pro Ile Cys Leu Pro Asp Ala Ser 
                725                 730                 735     


His Val Phe Pro Ala Gly Lys Ala Ile Trp Val Thr Gly Trp Gly His 
            740                 745                 750         


Thr Gln Tyr Gly Gly Thr Gly Ala Leu Ile Leu Gln Lys Gly Glu Ile 
        755                 760                 765             


Arg Val Ile Asn Gln Thr Thr Cys Glu Asn Leu Leu Pro Gln Gln Ile 
    770                 775                 780                 


Thr Pro Arg Met Met Cys Val Gly Phe Leu Ser Gly Gly Val Asp Ser 
785                 790                 795                 800 


Cys Gln Gly Asp Ser Gly Gly Pro Leu Ser Ser Val Glu Ala Asp Gly 
                805                 810                 815     


Arg Ile Phe Gln Ala Gly Val Val Ser Trp Gly Asp Gly Cys Ala Gln 
            820                 825                 830         


Arg Asn Lys Pro Gly Val Tyr Thr Arg Leu Pro Leu Phe Arg Asp Trp 
        835                 840                 845             


Ile Lys Glu Asn Thr Gly Val 
    850                 855 


<210>  4859
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  4859

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Thr Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Gln Pro Arg Phe Leu Glu Gln Ala Lys Cys Glu Cys His Phe Leu Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Trp Asn Leu Ile Arg Tyr Ile Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Tyr Ala Arg Tyr Asn Ser Asp Leu Gly Glu Tyr Gln Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Arg Arg Arg Ala Glu Val Asp Thr Tyr Cys Arg Tyr Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Gln Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Met Met Ser Pro Leu Thr Val Gln Trp Ser Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Thr Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Leu Leu Ser 
            260                 265     


<210>  4860
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  4860

Met Pro Gly Glu Val Gln Ala Ser Tyr Leu Lys Ser Gln Ser Lys Leu 
1               5                   10                  15      


Ser Asp Glu Gly Arg Leu Glu Pro Arg Lys Phe His Cys Lys Gly Val 
            20                  25                  30          


Lys Val Pro Arg Asn Phe Arg Leu Leu Glu Glu Leu Glu Glu Gly Gln 
        35                  40                  45              


Lys Gly Val Gly Asp Gly Thr Val Ser Trp Gly Leu Glu Asp Asp Glu 
    50                  55                  60                  


Asp Met Thr Leu Thr Arg Trp Thr Gly Met Ile Ile Gly Pro Pro Arg 
65                  70                  75                  80  


Thr Ile Tyr Glu Asn Arg Ile Tyr Ser Leu Lys Ile Glu Cys Gly Pro 
                85                  90                  95      


Lys Tyr Pro Glu Ala Pro Pro Phe Val Arg Phe Val Thr Lys Ile Asn 
            100                 105                 110         


Met Asn Gly Val Asn Ser Ser Asn Gly Val Val Asp Pro Arg Ala Ile 
        115                 120                 125             


Ser Val Leu Ala Lys Trp Gln Asn Ser Tyr Ser Ile Lys Val Val Leu 
    130                 135                 140                 


Gln Glu Leu Arg Arg Leu Met Met Ser Lys Glu Asn Met Lys Leu Pro 
145                 150                 155                 160 


Gln Pro Pro Glu Gly Gln Cys Tyr Ser Asn 
                165                 170 


<210>  4861
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  4861

Met His Arg Arg Arg Leu Ala Leu Gly Leu Gly Phe Cys Leu Leu Ala 
1               5                   10                  15      


Gly Thr Ser Leu Ser Val Leu Trp Val Tyr Leu Glu Asn Trp Leu Pro 
            20                  25                  30          


Val Ser Tyr Val Pro Tyr Tyr Leu Pro Cys Pro Glu Ile Phe Asn Met 
        35                  40                  45              


Lys Leu His Tyr Lys Arg Glu Lys Pro Leu Gln Pro Val Val Trp Ser 
    50                  55                  60                  


Gln Tyr Pro Gln Pro Lys Leu Leu Glu His Arg Pro Thr Gln Leu Leu 
65                  70                  75                  80  


Thr Leu Thr Pro Trp Leu Ala Pro Ile Val Ser Glu Gly Thr Phe Asn 
                85                  90                  95      


Pro Glu Leu Leu Gln His Ile Tyr Gln Pro Leu Asn Leu Thr Ile Gly 
            100                 105                 110         


Val Thr Val Phe Ala Val Gly Lys Tyr Thr His Phe Ile Gln Ser Phe 
        115                 120                 125             


Leu Glu Ser Ala Glu Glu Phe Phe Met Arg Gly Tyr Arg Val His Tyr 
    130                 135                 140                 


Tyr Ile Phe Thr Asp Asn Pro Ala Ala Val Pro Gly Val Pro Leu Gly 
145                 150                 155                 160 


Pro His Arg Leu Leu Ser Ser Ile Pro Ile Gln Gly His Ser His Trp 
                165                 170                 175     


Glu Glu Thr Ser Met Arg Arg Met Glu Thr Ile Ser Gln His Ile Ala 
            180                 185                 190         


Lys Arg Ala His Arg Glu Val Asp Tyr Leu Phe Cys Leu Asp Val Asp 
        195                 200                 205             


Met Val Phe Arg Asn Pro Trp Gly Pro Glu Thr Leu Gly Asp Leu Val 
    210                 215                 220                 


Ala Ala Ile His Pro Ser Tyr Tyr Ala Val Pro Arg Gln Gln Phe Pro 
225                 230                 235                 240 


Tyr Glu Arg Arg Arg Val Ser Thr Ala Phe Val Ala Asp Ser Glu Gly 
                245                 250                 255     


Asp Phe Tyr Tyr Gly Gly Ala Val Phe Gly Gly Gln Val Ala Arg Val 
            260                 265                 270         


Tyr Glu Phe Thr Arg Gly Cys His Met Ala Ile Leu Ala Asp Lys Ala 
        275                 280                 285             


Asn Gly Ile Met Ala Ala Trp Arg Glu Glu Ser His Leu Asn Arg His 
    290                 295                 300                 


Phe Ile Ser Asn Lys Pro Ser Lys Val Leu Ser Pro Glu Tyr Leu Trp 
305                 310                 315                 320 


Asp Asp Arg Lys Pro Gln Pro Pro Ser Leu Lys Leu Ile Arg Phe Ser 
                325                 330                 335     


Thr Leu Asp Lys Asp Ile Ser Cys Leu Arg Ser 
            340                 345         


<210>  4862
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  4862

Met Val Lys Val Thr Phe Asn Ser Ala Leu Ala Gln Lys Glu Ala Lys 
1               5                   10                  15      


Lys Asp Glu Pro Lys Ser Gly Glu Glu Ala Leu Ile Ile Pro Pro Asp 
            20                  25                  30          


Ala Val Ala Val Asp Cys Lys Asp Pro Asp Asp Val Val Pro Val Gly 
        35                  40                  45              


Gln Arg Arg Ala Trp Cys Trp Cys Met Cys Phe Gly Leu Ala Phe Met 
    50                  55                  60                  


Leu Ala Gly Val Ile Leu Gly Gly Ala Tyr Leu Tyr Lys Tyr Phe Ala 
65                  70                  75                  80  


Leu Gln Pro Asp Asp Val Tyr Tyr Cys Gly Ile Lys Tyr Ile Lys Asp 
                85                  90                  95      


Asp Val Ile Leu Asn Glu Pro Ser Ala Asp Ala Pro Ala Ala Leu Tyr 
            100                 105                 110         


Gln Thr Ile Glu Glu Asn Ile Lys Ile Phe Glu Glu Glu Glu Val Glu 
        115                 120                 125             


Phe Ile Ser Val Pro Val Pro Glu Phe Ala Asp Ser Asp Pro Ala Asn 
    130                 135                 140                 


Ile Val His Asp Phe Asn Lys Lys Leu Thr Ala Tyr Leu Asp Leu Asn 
145                 150                 155                 160 


Leu Asp Lys Cys Tyr Val Ile Pro Leu Asn Thr Ser Ile Val Met Pro 
                165                 170                 175     


Pro Arg Asn Leu Leu Glu Leu Leu Ile Asn Ile Lys Ala Gly Thr Tyr 
            180                 185                 190         


Leu Pro Gln Ser Tyr Leu Ile His Glu His Met Val Ile Thr Asp Arg 
        195                 200                 205             


Ile Glu Asn Ile Asp His Leu Gly Phe Phe Ile Tyr Arg Leu Cys His 
    210                 215                 220                 


Asp Lys Glu Thr Tyr Lys Leu Gln Arg Arg Glu Thr Ile Lys Gly Ile 
225                 230                 235                 240 


Gln Lys Arg Glu Ala Ser Asn Cys Phe Ala Ile Arg His Phe Glu Asn 
                245                 250                 255     


Lys Phe Ala Val Glu Thr Leu Ile Cys Ser 
            260                 265     


<210>  4863
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  4863

Met Glu Leu Val Leu Val Phe Leu Cys Ser Leu Leu Ala Pro Met Val 
1               5                   10                  15      


Leu Ala Ser Ala Ala Glu Lys Glu Lys Glu Met Asp Pro Phe His Tyr 
            20                  25                  30          


Asp Tyr Gln Thr Leu Arg Ile Gly Gly Leu Val Phe Ala Val Val Leu 
        35                  40                  45              


Phe Ser Val Gly Ile Leu Leu Ile Leu Ser Arg Arg Cys Lys Cys Ser 
    50                  55                  60                  


Phe Asn Gln Lys Pro Arg Ala Pro Gly Asp Glu Glu Ala Gln Val Glu 
65                  70                  75                  80  


Asn Leu Ile Thr Ala Asn Ala Thr Glu Pro Gln Lys Ala Glu Asn 
                85                  90                  95  


<210>  4864
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  4864

Met Ala Thr Pro Thr Gln Thr Pro Thr Lys Ala Pro Glu Glu Pro Asp 
1               5                   10                  15      


Pro Phe Tyr Tyr Asp Tyr Asn Thr Val Gln Thr Val Gly Met Thr Leu 
            20                  25                  30          


Ala Thr Ile Leu Phe Leu Leu Gly Ile Leu Ile Val Ile Ser Lys Lys 
        35                  40                  45              


Val Lys Cys Arg Lys Ala Asp Ser Arg Ser Glu Ser Pro Thr Cys Lys 
    50                  55                  60                  


Ser Cys Lys Ser Glu Leu Pro Ser Ser Ala Pro Gly Gly Gly Gly Val 
65                  70                  75                  80  


<210>  4865
<211>  486
<212>  PRT
<213>  Homo sapiens

<400>  4865

Met Arg Gly Arg Gly Ser Gln Gln Gln Gln Pro Thr Arg Arg Gln Gly 
1               5                   10                  15      


Gln Lys Leu Pro Ser Pro Ser Pro Ala Gly Lys Tyr Glu Ser Ala Gln 
            20                  25                  30          


Pro Gly Gly Thr Gln Pro Glu Pro Gly Leu Gly Ala Arg Met Ala Ile 
        35                  40                  45              


His Lys Ala Leu Val Met Cys Leu Gly Leu Pro Leu Phe Leu Phe Pro 
    50                  55                  60                  


Gly Ala Trp Ala Gln Gly His Val Pro Pro Gly Cys Ser Gln Gly Leu 
65                  70                  75                  80  


Asn Pro Leu Tyr Tyr Asn Leu Cys Asp Arg Ser Gly Ala Trp Gly Ile 
                85                  90                  95      


Val Leu Glu Ala Val Ala Gly Ala Gly Ile Val Thr Thr Phe Val Leu 
            100                 105                 110         


Thr Ile Ile Leu Val Ala Ser Leu Pro Phe Val Gln Asp Thr Lys Lys 
        115                 120                 125             


Arg Ser Leu Leu Gly Thr Gln Val Phe Phe Leu Leu Gly Thr Leu Gly 
    130                 135                 140                 


Leu Phe Cys Leu Val Phe Ala Cys Val Val Lys Pro Asp Phe Ser Thr 
145                 150                 155                 160 


Cys Ala Ser Arg Arg Phe Leu Phe Gly Val Leu Phe Ala Ile Cys Phe 
                165                 170                 175     


Ser Cys Leu Ala Ala His Val Phe Ala Leu Asn Phe Leu Ala Arg Lys 
            180                 185                 190         


Asn His Gly Pro Arg Gly Trp Val Ile Phe Thr Val Ala Leu Leu Leu 
        195                 200                 205             


Thr Leu Val Glu Val Ile Ile Asn Thr Glu Trp Leu Ile Ile Thr Leu 
    210                 215                 220                 


Val Arg Gly Ser Gly Glu Gly Gly Pro Gln Gly Asn Ser Ser Ala Gly 
225                 230                 235                 240 


Trp Ala Val Ala Ser Pro Cys Ala Ile Ala Asn Met Asp Phe Val Met 
                245                 250                 255     


Ala Leu Ile Tyr Val Met Leu Leu Leu Leu Gly Ala Phe Leu Gly Ala 
            260                 265                 270         


Trp Pro Ala Leu Cys Gly Arg Tyr Lys Arg Trp Arg Lys His Gly Val 
        275                 280                 285             


Phe Val Leu Leu Thr Thr Ala Thr Ser Val Ala Ile Trp Val Val Trp 
    290                 295                 300                 


Ile Val Met Tyr Thr Tyr Gly Asn Lys Gln His Asn Ser Pro Thr Trp 
305                 310                 315                 320 


Asp Asp Pro Thr Leu Ala Ile Ala Leu Ala Ala Asn Ala Trp Ala Phe 
                325                 330                 335     


Val Leu Phe Tyr Val Ile Pro Glu Val Ser Gln Val Thr Lys Ser Ser 
            340                 345                 350         


Pro Glu Gln Ser Tyr Gln Gly Asp Met Tyr Pro Thr Arg Gly Val Gly 
        355                 360                 365             


Tyr Glu Thr Ile Leu Lys Glu Gln Lys Gly Gln Ser Met Phe Val Glu 
    370                 375                 380                 


Asn Lys Ala Phe Ser Met Asp Glu Pro Val Ala Ala Lys Arg Pro Val 
385                 390                 395                 400 


Ser Pro Tyr Ser Gly Tyr Asn Gly Gln Leu Leu Thr Ser Val Tyr Gln 
                405                 410                 415     


Pro Thr Glu Met Ala Leu Met His Lys Val Pro Ser Glu Gly Ala Tyr 
            420                 425                 430         


Asp Ile Ile Leu Pro Arg Ala Thr Ala Asn Ser Gln Val Met Gly Ser 
        435                 440                 445             


Ala Asn Ser Thr Leu Arg Ala Glu Asp Met Tyr Ser Ala Gln Ser His 
    450                 455                 460                 


Gln Ala Ala Thr Pro Pro Lys Asp Gly Lys Asn Ser Gln Val Phe Arg 
465                 470                 475                 480 


Asn Pro Tyr Val Trp Asp 
                485     


<210>  4866
<211>  701
<212>  PRT
<213>  Homo sapiens

<400>  4866

Met Asp Glu Ser Pro Glu Pro Leu Gln Gln Gly Arg Gly Pro Val Pro 
1               5                   10                  15      


Val Arg Arg Gln Arg Pro Ala Pro Arg Gly Leu Arg Glu Met Leu Lys 
            20                  25                  30          


Ala Arg Leu Trp Cys Ser Cys Ser Cys Ser Val Leu Cys Val Arg Ala 
        35                  40                  45              


Leu Val Gln Asp Leu Leu Pro Ala Thr Arg Trp Leu Arg Gln Tyr Arg 
    50                  55                  60                  


Pro Arg Glu Tyr Leu Ala Gly Asp Val Met Ser Gly Leu Val Ile Gly 
65                  70                  75                  80  


Ile Ile Leu Val Pro Gln Ala Ile Ala Tyr Ser Leu Leu Ala Gly Leu 
                85                  90                  95      


Gln Pro Ile Tyr Ser Leu Tyr Thr Ser Phe Phe Ala Asn Leu Ile Tyr 
            100                 105                 110         


Phe Leu Met Gly Thr Ser Arg His Val Ser Val Gly Ile Phe Ser Leu 
        115                 120                 125             


Leu Cys Leu Met Val Gly Gln Val Val Asp Arg Glu Leu Gln Leu Ala 
    130                 135                 140                 


Gly Phe Asp Pro Ser Gln Asp Gly Leu Gln Pro Gly Ala Asn Ser Ser 
145                 150                 155                 160 


Thr Leu Asn Gly Ser Ala Ala Met Leu Asp Cys Gly Arg Asp Cys Tyr 
                165                 170                 175     


Ala Ile Arg Val Ala Thr Ala Leu Thr Leu Met Thr Gly Leu Tyr Gln 
            180                 185                 190         


Val Leu Met Gly Val Leu Arg Leu Gly Phe Val Ser Ala Tyr Leu Ser 
        195                 200                 205             


Gln Pro Leu Leu Asp Gly Phe Ala Met Gly Ala Ser Val Thr Ile Leu 
    210                 215                 220                 


Thr Ser Gln Leu Lys His Leu Leu Gly Val Arg Ile Pro Arg His Gln 
225                 230                 235                 240 


Gly Pro Gly Met Val Val Leu Thr Trp Leu Ser Leu Leu Arg Gly Ala 
                245                 250                 255     


Gly Gln Ala Asn Val Cys Asp Val Val Thr Ser Thr Val Cys Leu Ala 
            260                 265                 270         


Val Leu Leu Ala Ala Lys Glu Leu Ser Asp Arg Tyr Arg His Arg Leu 
        275                 280                 285             


Arg Val Pro Leu Pro Thr Glu Leu Leu Val Ile Val Val Ala Thr Leu 
    290                 295                 300                 


Val Ser His Phe Gly Gln Leu His Lys Arg Phe Gly Ser Ser Val Ala 
305                 310                 315                 320 


Gly Asp Ile Pro Thr Gly Phe Met Pro Pro Gln Val Pro Glu Pro Arg 
                325                 330                 335     


Leu Met Gln Arg Val Ala Leu Asp Ala Val Ala Leu Ala Leu Val Ala 
            340                 345                 350         


Ala Ala Phe Ser Ile Ser Leu Ala Glu Met Phe Ala Arg Ser His Gly 
        355                 360                 365             


Tyr Ser Val Arg Ala Asn Gln Glu Leu Leu Ala Val Gly Cys Cys Asn 
    370                 375                 380                 


Val Leu Pro Ala Phe Leu His Cys Phe Ala Thr Ser Ala Ala Leu Ala 
385                 390                 395                 400 


Lys Ser Leu Val Lys Thr Ala Thr Gly Cys Arg Thr Gln Leu Ser Ser 
                405                 410                 415     


Val Val Ser Ala Thr Val Val Leu Leu Val Leu Leu Ala Leu Ala Pro 
            420                 425                 430         


Leu Phe His Asp Leu Gln Arg Ser Val Leu Ala Cys Val Ile Val Val 
        435                 440                 445             


Ser Leu Arg Gly Ala Leu Arg Lys Val Trp Asp Leu Pro Arg Leu Trp 
    450                 455                 460                 


Arg Met Ser Pro Ala Asp Ala Leu Val Trp Ala Gly Thr Ala Ala Thr 
465                 470                 475                 480 


Cys Met Leu Val Ser Thr Glu Ala Gly Leu Leu Ala Gly Val Ile Leu 
                485                 490                 495     


Ser Leu Leu Ser Leu Ala Gly Arg Thr Gln Arg Pro Arg Thr Ala Leu 
            500                 505                 510         


Leu Ala Arg Ile Gly Asp Thr Ala Phe Tyr Glu Asp Ala Thr Glu Phe 
        515                 520                 525             


Glu Gly Leu Val Pro Glu Pro Gly Val Arg Val Phe Arg Phe Gly Gly 
    530                 535                 540                 


Pro Leu Tyr Tyr Ala Asn Lys Asp Phe Phe Leu Gln Ser Leu Tyr Ser 
545                 550                 555                 560 


Leu Thr Gly Leu Asp Ala Gly Cys Met Ala Ala Arg Arg Lys Glu Gly 
                565                 570                 575     


Gly Ser Glu Thr Gly Val Gly Glu Gly Gly Pro Ala Gln Gly Glu Asp 
            580                 585                 590         


Leu Gly Pro Val Ser Thr Arg Ala Ala Leu Val Pro Ala Ala Ala Gly 
        595                 600                 605             


Phe His Thr Val Val Ile Asp Cys Ala Pro Leu Leu Phe Leu Asp Ala 
    610                 615                 620                 


Ala Gly Val Ser Thr Leu Gln Asp Leu Arg Arg Asp Tyr Gly Ala Leu 
625                 630                 635                 640 


Gly Ile Ser Leu Leu Leu Ala Cys Cys Ser Pro Pro Val Arg Asp Ile 
                645                 650                 655     


Leu Ser Arg Gly Gly Phe Leu Gly Glu Gly Pro Gly Asp Thr Ala Glu 
            660                 665                 670         


Glu Glu Gln Leu Phe Leu Ser Val His Asp Ala Val Gln Thr Ala Arg 
        675                 680                 685             


Ala Arg His Arg Glu Leu Glu Ala Thr Asp Ala His Leu 
    690                 695                 700     


<210>  4867
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  4867

Met Trp Ser Ala Gly Arg Gly Gly Ala Ala Trp Pro Val Leu Leu Gly 
1               5                   10                  15      


Leu Leu Leu Ala Leu Leu Val Pro Gly Gly Gly Ala Ala Lys Thr Gly 
            20                  25                  30          


Ala Glu Leu Val Thr Cys Gly Ser Val Leu Lys Leu Leu Asn Thr His 
        35                  40                  45              


His Arg Val Arg Leu His Ser His Asp Ile Lys Tyr Gly Ser Gly Ser 
    50                  55                  60                  


Gly Gln Gln Ser Val Thr Gly Val Glu Ala Ser Asp Asp Ala Asn Ser 
65                  70                  75                  80  


Tyr Trp Arg Ile Arg Gly Gly Ser Glu Gly Gly Cys Pro Arg Gly Ser 
                85                  90                  95      


Pro Val Arg Cys Gly Gln Ala Val Arg Leu Thr His Val Leu Thr Gly 
            100                 105                 110         


Lys Asn Leu His Thr His His Phe Pro Ser Pro Leu Ser Asn Asn Gln 
        115                 120                 125             


Glu Val Ser Ala Phe Gly Glu Asp Gly Glu Gly Asp Asp Leu Asp Leu 
    130                 135                 140                 


Trp Thr Val Arg Cys Ser Gly Gln His Trp Glu Arg Glu Ala Ala Val 
145                 150                 155                 160 


Arg Phe Gln His Val Gly Thr Ser Val Phe Leu Ser Val Thr Gly Glu 
                165                 170                 175     


Gln Tyr Gly Ser Pro Ile Arg Gly Gln His Glu Val His Gly Met Pro 
            180                 185                 190         


Ser Ala Asn Thr His Asn Thr Trp Lys Ala Met Glu Gly Ile Phe Ile 
        195                 200                 205             


Lys Pro Ser Val Glu Pro Ser Ala Gly His Asp Glu Leu 
    210                 215                 220     


<210>  4868
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  4868

Met Thr Asn Ser Ser Ser Thr Ser Thr Ser Ser Thr Thr Gly Gly Ser 
1               5                   10                  15      


Leu Leu Leu Leu Cys Glu Glu Glu Glu Ser Trp Ala Gly Arg Arg Ile 
            20                  25                  30          


Pro Val Ser Leu Leu Tyr Ser Gly Leu Ala Ile Gly Gly Thr Leu Ala 
        35                  40                  45              


Asn Gly Met Val Ile Tyr Leu Val Ser Ser Phe Arg Lys Leu Gln Thr 
    50                  55                  60                  


Thr Ser Asn Ala Phe Ile Val Asn Gly Cys Ala Ala Asp Leu Ser Val 
65                  70                  75                  80  


Cys Ala Leu Trp Met Pro Gln Glu Ala Val Leu Gly Leu Leu Pro Thr 
                85                  90                  95      


Gly Ser Ala Glu Pro Pro Ala Asp Trp Asp Gly Ala Gly Gly Ser Tyr 
            100                 105                 110         


Arg Leu Leu Arg Gly Gly Leu Leu Gly Leu Gly Leu Thr Val Ser Leu 
        115                 120                 125             


Leu Ser His Cys Leu Val Ala Leu Asn Arg Tyr Leu Leu Ile Thr Arg 
    130                 135                 140                 


Ala Pro Ala Thr Tyr Gln Ala Leu Tyr Gln Arg Arg His Thr Ala Gly 
145                 150                 155                 160 


Met Leu Ala Leu Ser Trp Ala Leu Ala Leu Gly Leu Val Leu Leu Leu 
                165                 170                 175     


Pro Pro Trp Ala Pro Arg Pro Gly Ala Ala Pro Pro Arg Val His Tyr 
            180                 185                 190         


Pro Ala Leu Leu Ala Ala Ala Ala Leu Leu Ala Gln Thr Ala Leu Leu 
        195                 200                 205             


Leu His Cys Tyr Leu Gly Ile Val Arg Arg Val Arg Val Ser Val Lys 
    210                 215                 220                 


Arg Val Ser Val Leu Asn Phe His Leu Leu His Gln Leu Pro Gly Cys 
225                 230                 235                 240 


Ala Ala Ala Ala Ala Ala Phe Pro Gly Ala Gln His Ala Pro Gly Pro 
                245                 250                 255     


Gly Gly Ala Ala His Pro Ala Gln Ala Gln Pro Leu Pro Pro Ala Leu 
            260                 265                 270         


His Pro Arg Arg Ala Gln Arg Arg Leu Ser Gly Leu Ser Val Leu Leu 
        275                 280                 285             


Leu Cys Cys Val Phe Leu Leu Ala Thr Gln Pro Leu Val Trp Val Ser 
    290                 295                 300                 


Leu Ala Ser Gly Phe Ser Leu Pro Val Pro Trp Gly Val Gln Ala Ala 
305                 310                 315                 320 


Ser Trp Leu Leu Cys Cys Ala Leu Ser Ala Leu Asn Pro Leu Leu Tyr 
                325                 330                 335     


Thr Trp Arg Asn Glu Glu Phe Arg Arg Ser Val Arg Ser Val Leu Pro 
            340                 345                 350         


Gly Val Gly Asp Ala Ala Ala Ala Ala Val Ala Ala Thr Ala Val Pro 
        355                 360                 365             


Ala Val Ser Gln Ala Gln Leu Gly Thr Arg Ala Ala Gly Gln His Trp 
    370                 375                 380                 


<210>  4869
<211>  408
<212>  PRT
<213>  Homo sapiens

<400>  4869

Met Ala Gly Arg Gly Phe Ser Trp Gly Pro Gly His Leu Asn Glu Asp 
1               5                   10                  15      


Asn Ala Arg Phe Leu Leu Leu Ala Ala Leu Ile Val Leu Tyr Leu Leu 
            20                  25                  30          


Gly Gly Ala Ala Val Phe Ser Ala Leu Glu Leu Ala His Glu Arg Gln 
        35                  40                  45              


Ala Lys Gln Arg Trp Glu Glu Arg Leu Ala Asn Phe Ser Arg Gly His 
    50                  55                  60                  


Asn Leu Ser Arg Asp Glu Leu Arg Gly Phe Leu Arg His Tyr Glu Glu 
65                  70                  75                  80  


Ala Thr Arg Ala Gly Ile Arg Val Asp Asn Val Arg Pro Arg Trp Asp 
                85                  90                  95      


Phe Thr Gly Ala Phe Tyr Phe Val Gly Thr Val Val Ser Thr Ile Gly 
            100                 105                 110         


Phe Gly Met Thr Thr Pro Ala Thr Val Gly Gly Lys Ile Phe Leu Ile 
        115                 120                 125             


Phe Tyr Gly Leu Val Gly Cys Ser Ser Thr Ile Leu Phe Phe Asn Leu 
    130                 135                 140                 


Phe Leu Glu Arg Leu Ile Thr Ile Ile Ala Tyr Ile Met Lys Ser Cys 
145                 150                 155                 160 


His Gln Arg Gln Leu Arg Arg Arg Gly Ala Leu Pro Gln Glu Ser Leu 
                165                 170                 175     


Lys Asp Ala Gly Gln Cys Glu Val Asp Ser Leu Ala Gly Trp Lys Pro 
            180                 185                 190         


Ser Val Tyr Tyr Val Met Leu Ile Leu Cys Thr Ala Ser Ile Leu Ile 
        195                 200                 205             


Ser Cys Cys Ala Ser Ala Met Tyr Thr Pro Ile Glu Gly Trp Ser Tyr 
    210                 215                 220                 


Phe Asp Ser Leu Tyr Phe Cys Phe Val Ala Phe Ser Thr Ile Gly Phe 
225                 230                 235                 240 


Gly Asp Leu Val Ser Ser Gln Asn Ala His Tyr Glu Ser Gln Gly Leu 
                245                 250                 255     


Tyr Arg Phe Ala Asn Phe Val Phe Ile Leu Met Gly Val Cys Cys Ile 
            260                 265                 270         


Tyr Ser Leu Phe Asn Val Ile Ser Ile Leu Ile Lys Gln Ser Leu Asn 
        275                 280                 285             


Trp Ile Leu Arg Lys Met Asp Ser Gly Cys Cys Pro Gln Cys Gln Arg 
    290                 295                 300                 


Gly Leu Leu Arg Ser Arg Arg Asn Val Val Met Pro Gly Ser Val Arg 
305                 310                 315                 320 


Asn Arg Cys Asn Ile Ser Ile Glu Thr Asp Gly Val Ala Glu Ser Asp 
                325                 330                 335     


Thr Asp Gly Arg Arg Leu Ser Gly Glu Met Ile Ser Met Lys Asp Leu 
            340                 345                 350         


Leu Ala Ala Asn Lys Ala Ser Leu Ala Ile Leu Gln Lys Gln Leu Ser 
        355                 360                 365             


Glu Met Ala Asn Gly Cys Pro His Gln Thr Ser Thr Leu Ala Arg Asp 
    370                 375                 380                 


Asn Glu Phe Ser Gly Gly Val Gly Ala Phe Ala Ile Met Asn Asn Arg 
385                 390                 395                 400 


Leu Ala Glu Thr Ser Gly Asp Arg 
                405             


<210>  4870
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  4870

Met Ser Gly Ser Gln Ser Glu Val Ala Pro Ser Pro Gln Ser Pro Arg 
1               5                   10                  15      


Ser Pro Glu Met Gly Arg Asp Leu Arg Pro Gly Ser Arg Val Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Leu Leu Val Tyr Leu Thr Gln Pro Gly Asn Gly 
        35                  40                  45              


Asn Glu Gly Ser Val Thr Gly Ser Cys Tyr Cys Gly Lys Arg Ile Ser 
    50                  55                  60                  


Ser Asp Ser Pro Pro Ser Val Gln Phe Met Asn Arg Leu Arg Lys His 
65                  70                  75                  80  


Leu Arg Ala Tyr His Arg Cys Leu Tyr Tyr Thr Arg Phe Gln Leu Leu 
                85                  90                  95      


Ser Trp Ser Val Cys Gly Gly Asn Lys Asp Pro Trp Val Gln Glu Leu 
            100                 105                 110         


Met Ser Cys Leu Asp Leu Lys Glu Cys Gly His Ala Tyr Ser Gly Ile 
        115                 120                 125             


Val Ala His Gln Lys His Leu Leu Pro Thr Ser Pro Pro Ile Ser Gln 
    130                 135                 140                 


Ala Ser Glu Gly Ala Ser Ser Asp Ile His Thr Pro Ala Gln Met Leu 
145                 150                 155                 160 


Leu Ser Thr Leu Gln Ser Thr Gln Arg Pro Thr Leu Pro Val Gly Ser 
                165                 170                 175     


Leu Ser Ser Asp Lys Glu Leu Thr Arg Pro Asn Glu Thr Thr Ile His 
            180                 185                 190         


Thr Ala Gly His Ser Leu Ala Ala Gly Pro Glu Ala Gly Glu Asn Gln 
        195                 200                 205             


Lys Gln Pro Glu Lys Asn Ala Gly Pro Thr Ala Arg Thr Ser Ala Thr 
    210                 215                 220                 


Val Pro Val Leu Cys Leu Leu Ala Ile Ile Phe Ile Leu Thr Ala Ala 
225                 230                 235                 240 


Leu Ser Tyr Val Leu Cys Lys Arg Arg Arg Gly Gln Ser Pro Gln Ser 
                245                 250                 255     


Ser Pro Asp Leu Pro Val His Tyr Ile Pro Val Ala Pro Asp Ser Asn 
            260                 265                 270         


Thr 
    


<210>  4871
<211>  1953
<212>  PRT
<213>  Homo sapiens

<400>  4871

Met Gly Val Lys Lys Lys Lys Glu Met Gln Val Ala Ala Leu Thr Ile 
1               5                   10                  15      


Cys His Gln Asp Leu Glu Thr Leu Lys Ser Phe Ala Asp Val Glu Gly 
            20                  25                  30          


Lys Asn Leu Ala Ser Leu Leu Leu His Cys Val Gln Leu Thr Asp Gly 
        35                  40                  45              


Val Ser Gln Ile His Tyr Ile Lys Gln Ile Val Pro Leu Leu Glu Lys 
    50                  55                  60                  


Ala Asp Lys Asn Gly Met Cys Asp Pro Thr Ile Gln Ser Cys Leu Asp 
65                  70                  75                  80  


Ile Leu Ala Gly Ile Tyr Leu Ser Leu Ser Leu Lys Asn Pro Leu Lys 
                85                  90                  95      


Lys Val Leu Ala Ser Ser Leu Asn Ser Leu Pro Asp Phe Phe Leu Pro 
            100                 105                 110         


Glu Ala Met His Arg Phe Thr Ser Arg Leu Gln Glu Glu Leu Asn Thr 
        115                 120                 125             


Thr Asp Leu Tyr Ser Tyr Arg Lys Val Thr Asp Asn Ile Ser Ser Cys 
    130                 135                 140                 


Met Glu Asn Phe Asn Leu Gly Arg Ala Ser Val Asn Asn Leu Leu Lys 
145                 150                 155                 160 


Asn Val Leu His Phe Leu Gln Lys Ser Leu Ile Glu Ile Leu Glu Glu 
                165                 170                 175     


Asn Arg Lys Cys Ala Gly Asn His Ile Ile Gln Thr Gln Leu Met Asn 
            180                 185                 190         


Asp Leu Leu Val Gly Ile Arg Val Ser Met Met Leu Val Gln Lys Val 
        195                 200                 205             


Gln Asp Phe Gln Gly Asn Leu Trp Lys Thr Ser Asp Ser Pro Ile Trp 
    210                 215                 220                 


Gln Asn Met Cys Gly Leu Leu Ser Ile Phe Thr Lys Val Leu Ser Asp 
225                 230                 235                 240 


Asp Asp Leu Leu Gln Thr Val Gln Ser Thr Ser Gly Leu Ala Ile Ile 
                245                 250                 255     


Leu Phe Ile Lys Thr Met Phe His Pro Ser Glu Lys Ile Pro His Leu 
            260                 265                 270         


Ile Ser Ser Val Leu Leu Arg Ser Val Asp Cys Thr Ser Val Pro Glu 
        275                 280                 285             


Trp Phe Met Ser Ser Cys Arg Ser Leu Cys Cys Gly Asp Ile Ser Gln 
    290                 295                 300                 


Ser Ala Val Leu Phe Leu Cys Gln Gly Thr Leu Ala Met Leu Asp Trp 
305                 310                 315                 320 


Gln Asn Gly Ser Met Gly Arg Ser Gly Glu Ala Leu Leu Leu Asp Thr 
                325                 330                 335     


Ala His Val Leu Phe Thr Leu Ser Ser Gln Ile Lys Glu Pro Thr Leu 
            340                 345                 350         


Glu Met Phe Leu Ser Arg Ile Leu Ala Ser Trp Thr Asn Ser Ala Ile 
        355                 360                 365             


Gln Val Leu Glu Ser Ser Ser Pro Ser Leu Thr Asp Ser Leu Asn Gly 
    370                 375                 380                 


Asn Ser Ser Ile Val Gly Arg Leu Leu Glu Tyr Val Tyr Thr His Trp 
385                 390                 395                 400 


Glu His Pro Leu Asp Ala Leu Arg His Gln Thr Lys Ile Met Phe Lys 
                405                 410                 415     


Asn Leu Leu Gln Met His Arg Leu Thr Val Glu Gly Ala Asp Phe Val 
            420                 425                 430         


Pro Asp Pro Phe Phe Val Glu Leu Thr Glu Ser Leu Leu Arg Leu Glu 
        435                 440                 445             


Trp His Ile Lys Gly Lys Tyr Thr Cys Leu Gly Cys Leu Val Glu Cys 
    450                 455                 460                 


Ile Gly Val Glu His Ile Leu Ala Ile Asp Lys Thr Ile Pro Ser Gln 
465                 470                 475                 480 


Ile Leu Glu Val Met Gly Asp Gln Ser Leu Val Pro Tyr Ala Ser Asp 
                485                 490                 495     


Leu Leu Glu Thr Met Phe Arg Asn His Lys Ser His Leu Lys Ser Gln 
            500                 505                 510         


Thr Ala Glu Ser Ser Trp Ile Asp Gln Trp His Glu Thr Trp Val Ser 
        515                 520                 525             


Pro Leu Leu Phe Ile Leu Cys Glu Gly Asn Leu Asp Gln Lys Ser Tyr 
    530                 535                 540                 


Val Ile Asp Tyr Tyr Leu Pro Lys Leu Leu Ser Tyr Ser Pro Glu Ser 
545                 550                 555                 560 


Leu Gln Tyr Met Val Lys Ile Leu Gln Thr Ser Ile Asp Ala Lys Thr 
                565                 570                 575     


Gly Gln Glu Gln Ser Phe Pro Ser Leu Gly Ser Cys Asn Ser Arg Gly 
            580                 585                 590         


Ala Leu Gly Ala Leu Met Ala Cys Leu Arg Ile Ala Arg Ala His Gly 
        595                 600                 605             


His Leu Gln Ser Ala Thr Asp Thr Trp Glu Asn Leu Val Ser Asp Ala 
    610                 615                 620                 


Arg Ile Lys Gln Gly Leu Ile His Gln His Cys Gln Val Arg Ile Asp 
625                 630                 635                 640 


Thr Leu Gly Leu Leu Cys Glu Ser Asn Arg Ser Thr Glu Ile Val Ser 
                645                 650                 655     


Met Glu Glu Met Gln Trp Ile Gln Phe Phe Ile Thr Tyr Asn Leu Asn 
            660                 665                 670         


Ser Gln Ser Pro Gly Val Arg Gln Gln Ile Cys Ser Leu Leu Lys Lys 
        675                 680                 685             


Leu Phe Cys Arg Ile Gln Glu Ser Ser Gln Val Leu Tyr Lys Leu Glu 
    690                 695                 700                 


Gln Ser Lys Ser Lys Arg Glu Pro Glu Asn Glu Leu Thr Lys Gln His 
705                 710                 715                 720 


Pro Ser Val Ser Leu Gln Gln Tyr Lys Asn Phe Met Ser Ser Ile Cys 
                725                 730                 735     


Asn Ser Leu Phe Glu Ala Leu Phe Pro Gly Ser Ser Tyr Ser Thr Arg 
            740                 745                 750         


Phe Ser Ala Leu Thr Ile Leu Gly Ser Ile Ala Glu Val Phe His Val 
        755                 760                 765             


Pro Glu Gly Arg Ile Tyr Thr Val Tyr Gln Leu Ser His Asp Ile Asp 
    770                 775                 780                 


Val Gly Arg Phe Gln Thr Leu Met Glu Cys Phe Thr Ser Thr Phe Glu 
785                 790                 795                 800 


Asp Val Lys Ile Leu Ala Phe Asp Leu Leu Met Lys Leu Ser Lys Thr 
                805                 810                 815     


Ala Val His Phe Gln Asp Ser Gly Lys Leu Gln Gly Leu Phe Gln Ala 
            820                 825                 830         


Ala Leu Glu Leu Ser Thr Ser Thr Lys Pro Tyr Asp Cys Val Thr Ala 
        835                 840                 845             


Ser Tyr Leu Leu Asn Phe Leu Ile Trp Gln Asp Ala Leu Pro Ser Ser 
    850                 855                 860                 


Leu Ser Ala Tyr Leu Thr Gln Gln Val Ala Cys Asp Asn Gly Asp Arg 
865                 870                 875                 880 


Pro Ala Ala Val Val Glu Arg Asn Thr Leu Met Val Ile Lys Cys Leu 
                885                 890                 895     


Met Glu Asn Leu Glu Glu Glu Val Ser Gln Ala Glu Asn Ser Leu Leu 
            900                 905                 910         


Gln Ala Ala Ala Ala Phe Pro Met Tyr Gly Arg Val His Cys Ile Thr 
        915                 920                 925             


Gly Ala Leu Gln Lys Leu Ser Leu Asn Ser Leu Gln Leu Val Ser Glu 
    930                 935                 940                 


Trp Arg Pro Val Val Glu Lys Leu Leu Leu Met Ser Tyr Arg Leu Ser 
945                 950                 955                 960 


Thr Val Val Ser Pro Val Ile Gln Ser Ser Ser Pro Glu Gly Leu Ile 
                965                 970                 975     


Pro Met Asp Thr Asp Ser Glu Ser Ala Ser Arg Leu Gln Met Ile Leu 
            980                 985                 990         


Asn Glu Ile Gln Pro Arg Asp Thr  Asn Asp Tyr Phe Asn  Gln Ala Lys 
        995                 1000                 1005             


Ile Leu  Lys Glu His Asp Ser  Phe Asp Met Lys Asp  Leu Asn Ala 
    1010                 1015                 1020             


Ser Val  Val Asn Ile Asp Thr  Ser Thr Glu Ile Lys  Gly Lys Glu 
    1025                 1030                 1035             


Val Lys  Thr Cys Asp Val Thr  Ala Gln Met Val Leu  Val Cys Cys 
    1040                 1045                 1050             


Trp Arg  Ser Met Lys Glu Val  Ala Leu Leu Leu Gly  Met Leu Cys 
    1055                 1060                 1065             


Gln Leu  Leu Pro Met Gln Pro  Val Pro Glu Ser Ser  Asp Gly Leu 
    1070                 1075                 1080             


Leu Thr  Val Glu Gln Val Lys  Glu Ile Gly Asp Tyr  Phe Lys Gln 
    1085                 1090                 1095             


His Leu  Leu Gln Ser Arg His  Arg Gly Ala Phe Glu  Leu Ala Tyr 
    1100                 1105                 1110             


Thr Gly  Phe Val Lys Leu Thr  Glu Val Leu Asn Arg  Cys Pro Asn 
    1115                 1120                 1125             


Val Ser  Leu Gln Lys Leu Pro  Glu Gln Trp Leu Trp  Ser Val Leu 
    1130                 1135                 1140             


Glu Glu  Ile Lys Cys Ser Asp  Pro Ser Ser Lys Leu  Cys Ala Thr 
    1145                 1150                 1155             


Arg Arg  Ser Ala Gly Ile Pro  Phe Tyr Ile Gln Ala  Leu Leu Ala 
    1160                 1165                 1170             


Ser Glu  Pro Lys Lys Gly Arg  Met Asp Leu Leu Lys  Ile Thr Met 
    1175                 1180                 1185             


Lys Glu  Leu Ile Ser Leu Ala  Gly Pro Thr Asp Asp  Ile Gln Ser 
    1190                 1195                 1200             


Thr Val  Pro Gln Val His Ala  Leu Asn Ile Leu Arg  Ala Leu Phe 
    1205                 1210                 1215             


Arg Asp  Thr Arg Leu Gly Glu  Asn Ile Ile Pro Tyr  Val Ala Asp 
    1220                 1225                 1230             


Gly Ala  Lys Ala Ala Ile Leu  Gly Phe Thr Ser Pro  Val Trp Ala 
    1235                 1240                 1245             


Val Arg  Asn Ser Ser Thr Leu  Leu Phe Ser Ala Leu  Ile Thr Arg 
    1250                 1255                 1260             


Ile Phe  Gly Val Lys Arg Ala  Lys Asp Glu His Ser  Lys Thr Asn 
    1265                 1270                 1275             


Arg Met  Thr Gly Arg Glu Phe  Phe Ser Arg Phe Pro  Glu Leu Tyr 
    1280                 1285                 1290             


Pro Phe  Leu Leu Lys Gln Leu  Glu Thr Val Ala Asn  Thr Val Asp 
    1295                 1300                 1305             


Ser Asp  Met Gly Glu Pro Asn  Arg His Pro Ser Met  Phe Leu Leu 
    1310                 1315                 1320             


Leu Leu  Val Leu Glu Arg Leu  Tyr Ala Ser Pro Met  Asp Gly Thr 
    1325                 1330                 1335             


Ser Ser  Ala Leu Ser Met Gly  Pro Phe Val Pro Phe  Ile Met Arg 
    1340                 1345                 1350             


Cys Gly  His Ser Pro Val Tyr  His Ser Arg Glu Met  Ala Ala Arg 
    1355                 1360                 1365             


Ala Leu  Val Pro Phe Val Met  Ile Asp His Ile Pro  Asn Thr Ile 
    1370                 1375                 1380             


Arg Thr  Leu Leu Ser Thr Leu  Pro Ser Cys Thr Asp  Gln Cys Phe 
    1385                 1390                 1395             


Arg Gln  Asn His Ile His Gly  Thr Leu Leu Gln Val  Phe His Leu 
    1400                 1405                 1410             


Leu Gln  Ala Tyr Ser Asp Ser  Lys His Gly Thr Asn  Ser Asp Phe 
    1415                 1420                 1425             


Gln His  Glu Leu Thr Asp Ile  Thr Val Cys Thr Lys  Ala Lys Leu 
    1430                 1435                 1440             


Trp Leu  Ala Lys Arg Gln Asn  Pro Cys Leu Val Thr  Arg Ala Val 
    1445                 1450                 1455             


Tyr Ile  Asp Ile Leu Phe Leu  Leu Thr Cys Cys Leu  Asn Arg Ser 
    1460                 1465                 1470             


Ala Lys  Asp Asn Gln Pro Val  Leu Glu Ser Leu Gly  Phe Trp Glu 
    1475                 1480                 1485             


Glu Val  Arg Gly Ile Ile Ser  Gly Ser Glu Leu Ile  Thr Gly Phe 
    1490                 1495                 1500             


Pro Trp  Ala Phe Lys Val Pro  Gly Leu Pro Gln Tyr  Leu Gln Ser 
    1505                 1510                 1515             


Leu Thr  Arg Leu Ala Ile Ala  Ala Val Trp Ala Ala  Ala Ala Lys 
    1520                 1525                 1530             


Ser Gly  Glu Arg Glu Thr Asn  Val Pro Ile Ser Phe  Ser Gln Leu 
    1535                 1540                 1545             


Leu Glu  Ser Ala Phe Pro Glu  Val Arg Ser Leu Thr  Leu Glu Ala 
    1550                 1555                 1560             


Leu Leu  Glu Lys Phe Leu Ala  Ala Ala Ser Gly Leu  Gly Glu Lys 
    1565                 1570                 1575             


Gly Val  Pro Pro Leu Leu Cys  Asn Met Gly Glu Lys  Phe Leu Leu 
    1580                 1585                 1590             


Leu Ala  Met Lys Glu Asn His  Pro Glu Cys Phe Cys  Lys Ile Leu 
    1595                 1600                 1605             


Lys Ile  Leu His Cys Met Asp  Pro Gly Glu Trp Leu  Pro Gln Thr 
    1610                 1615                 1620             


Glu His  Cys Val His Leu Thr  Pro Lys Glu Phe Leu  Ile Trp Thr 
    1625                 1630                 1635             


Met Asp  Ile Ala Ser Asn Glu  Arg Ser Glu Ile Gln  Ser Val Ala 
    1640                 1645                 1650             


Leu Arg  Leu Ala Ser Lys Val  Ile Ser His His Met  Gln Thr Cys 
    1655                 1660                 1665             


Val Glu  Asn Arg Glu Leu Ile  Ala Ala Glu Leu Lys  Gln Trp Val 
    1670                 1675                 1680             


Gln Leu  Val Ile Leu Ser Cys  Glu Asp His Leu Pro  Thr Glu Ser 
    1685                 1690                 1695             


Arg Leu  Ala Val Val Glu Val  Leu Thr Ser Thr Thr  Pro Leu Phe 
    1700                 1705                 1710             


Leu Thr  Asn Pro His Pro Ile  Leu Glu Leu Gln Asp  Thr Leu Ala 
    1715                 1720                 1725             


Leu Trp  Lys Cys Val Leu Thr  Leu Leu Gln Ser Glu  Glu Gln Ala 
    1730                 1735                 1740             


Val Arg  Asp Ala Ala Thr Glu  Thr Val Thr Thr Ala  Met Ser Gln 
    1745                 1750                 1755             


Glu Asn  Thr Cys Gln Ser Thr  Glu Phe Ala Phe Cys  Gln Val Asp 
    1760                 1765                 1770             


Ala Ser  Ile Ala Leu Ala Leu  Ala Leu Ala Val Leu  Cys Asp Leu 
    1775                 1780                 1785             


Leu Gln  Gln Trp Asp Gln Leu  Ala Pro Gly Leu Pro  Ile Leu Leu 
    1790                 1795                 1800             


Gly Trp  Leu Leu Gly Glu Ser  Asp Asp Leu Val Ala  Cys Val Glu 
    1805                 1810                 1815             


Ser Met  His Gln Val Glu Glu  Asp Tyr Leu Phe Glu  Lys Ala Glu 
    1820                 1825                 1830             


Val Asn  Phe Trp Ala Glu Thr  Leu Ile Phe Val Lys  Tyr Leu Cys 
    1835                 1840                 1845             


Lys His  Leu Phe Cys Leu Leu  Ser Lys Ser Gly Trp  Arg Pro Pro 
    1850                 1855                 1860             


Ser Pro  Glu Met Leu Cys His  Leu Gln Arg Met Val  Ser Glu Gln 
    1865                 1870                 1875             


Cys His  Leu Leu Ser Gln Phe  Phe Arg Glu Leu Pro  Pro Ala Ala 
    1880                 1885                 1890             


Glu Phe  Val Lys Thr Val Glu  Phe Thr Arg Leu Arg  Ile Gln Glu 
    1895                 1900                 1905             


Glu Arg  Thr Leu Ala Cys Leu  Arg Leu Leu Ala Phe  Leu Glu Gly 
    1910                 1915                 1920             


Lys Glu  Gly Glu Asp Thr Leu  Val Leu Ser Val Trp  Asp Ser Tyr 
    1925                 1930                 1935             


Ala Glu  Ser Arg Gln Leu Thr  Leu Pro Arg Thr Glu  Ala Ala Cys 
    1940                 1945                 1950             


<210>  4872
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  4872

Met Leu Gln Thr Leu Tyr Asp Tyr Phe Trp Trp Glu Arg Leu Trp Leu 
1               5                   10                  15      


Pro Val Asn Leu Thr Trp Ala Asp Leu Glu Asp Arg Asp Gly Arg Val 
            20                  25                  30          


Tyr Ala Lys Ala Ser Asp Leu Tyr Ile Thr Leu Pro Leu Ala Leu Leu 
        35                  40                  45              


Phe Leu Ile Val Arg Tyr Phe Phe Glu Leu Tyr Val Ala Thr Pro Leu 
    50                  55                  60                  


Ala Ala Leu Leu Asn Ile Lys Glu Lys Thr Arg Leu Arg Ala Pro Pro 
65                  70                  75                  80  


Asn Ala Thr Leu Glu His Phe Tyr Leu Thr Ser Gly Lys Gln Pro Lys 
                85                  90                  95      


Gln Val Glu Val Glu Leu Leu Ser Arg Gln Ser Gly Leu Ser Gly Arg 
            100                 105                 110         


Gln Val Glu Arg Trp Phe Arg Arg Arg Arg Asn Gln Asp Arg Pro Ser 
        115                 120                 125             


Leu Leu Lys Lys Phe Arg Glu Ala Ser Trp Arg Phe Thr Phe Tyr Leu 
    130                 135                 140                 


Ile Ala Phe Ile Ala Gly Met Ala Val Ile Val Asp Lys Pro Trp Phe 
145                 150                 155                 160 


Tyr Asp Met Lys Lys Val Trp Glu Gly Tyr Pro Ile Gln Ser Thr Ile 
                165                 170                 175     


Pro Ser Gln Tyr Trp Tyr Tyr Met Ile Glu Leu Ser Phe Tyr Trp Ser 
            180                 185                 190         


Leu Leu Phe Ser Ile Ala Ser Asp Val Lys Arg Lys Asp Phe Lys Glu 
        195                 200                 205             


Gln Ile Ile His His Val Ala Thr Ile Ile Leu Ile Ser Phe Ser Trp 
    210                 215                 220                 


Phe Ala Asn Tyr Ile Arg Ala Gly Thr Leu Ile Met Ala Leu His Asp 
225                 230                 235                 240 


Ser Ser Asp Tyr Leu Leu Glu Ser Ala Lys Met Phe Asn Tyr Ala Gly 
                245                 250                 255     


Trp Lys Asn Thr Cys Asn Asn Ile Phe Ile Val Phe Ala Ile Val Phe 
            260                 265                 270         


Ile Ile Thr Arg Leu Val Ile Leu Pro Phe Trp Ile Leu His Cys Thr 
        275                 280                 285             


Leu Val Tyr Pro Leu Glu Leu Tyr Pro Ala Phe Phe Gly Tyr Tyr Phe 
    290                 295                 300                 


Phe Asn Ser Met Met Gly Val Leu Gln Leu Leu His Ile Phe Trp Ala 
305                 310                 315                 320 


Tyr Leu Ile Leu Arg Met Ala His Lys Phe Ile Thr Gly Lys Leu Val 
                325                 330                 335     


Glu Asp Glu Arg Ser Asp Arg Glu Glu Thr Glu Ser Ser Glu Gly Glu 
            340                 345                 350         


Glu Ala Ala Ala Gly Gly Gly Ala Lys Ser Arg Pro Leu Ala Asn Gly 
        355                 360                 365             


His Pro Ile Leu Asn Asn Asn His Arg Lys Asn Asp 
    370                 375                 380 


<210>  4873
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  4873

Met Ala Ser Asp Leu Asp Phe Ser Pro Pro Glu Val Pro Glu Pro Thr 
1               5                   10                  15      


Phe Leu Glu Asn Leu Leu Arg Tyr Gly Leu Phe Leu Gly Ala Ile Phe 
            20                  25                  30          


Gln Leu Ile Cys Val Leu Ala Ile Ile Val Pro Ile Pro Lys Ser His 
        35                  40                  45              


Glu Ala Glu Ala Glu Pro Ser Glu Pro Arg Ser Ala Glu Val Thr Arg 
    50                  55                  60                  


Lys Pro Lys Ala Ala Val Pro Ser Val Asn Lys Arg Pro Lys Lys Glu 
65                  70                  75                  80  


Thr Lys Lys Lys Arg 
                85  


<210>  4874
<211>  1057
<212>  PRT
<213>  Homo sapiens

<400>  4874

Met Leu Cys Trp Gly Asn Ala Ser Phe Gly Gln Leu Gly Leu Gly Gly 
1               5                   10                  15      


Ile Asp Glu Glu Ile Val Leu Glu Pro Arg Lys Ser Asp Phe Phe Ile 
            20                  25                  30          


Asn Lys Arg Val Arg Asp Val Gly Cys Gly Leu Arg His Thr Val Phe 
        35                  40                  45              


Val Leu Asp Asp Gly Thr Val Tyr Thr Cys Gly Cys Asn Asp Leu Gly 
    50                  55                  60                  


Gln Leu Gly His Glu Lys Ser Arg Lys Lys Pro Glu Gln Val Val Ala 
65                  70                  75                  80  


Leu Asp Ala Gln Asn Ile Val Ala Val Ser Cys Gly Glu Ala His Thr 
                85                  90                  95      


Leu Ala Leu Asn Asp Lys Gly Gln Val Tyr Ala Trp Gly Leu Asp Ser 
            100                 105                 110         


Asp Gly Gln Leu Gly Leu Val Gly Ser Glu Glu Cys Ile Arg Val Pro 
        115                 120                 125             


Arg Asn Ile Lys Ser Leu Ser Asp Ile Gln Ile Val Gln Val Ala Cys 
    130                 135                 140                 


Gly Tyr Tyr His Ser Leu Ala Leu Ser Lys Ala Ser Glu Val Phe Cys 
145                 150                 155                 160 


Trp Gly Gln Asn Lys Tyr Gly Gln Leu Gly Leu Gly Thr Asp Cys Lys 
                165                 170                 175     


Lys Gln Thr Ser Pro Gln Leu Leu Lys Ser Leu Leu Gly Ile Pro Phe 
            180                 185                 190         


Met Gln Val Ala Ala Gly Gly Ala His Ser Phe Val Leu Thr Leu Ser 
        195                 200                 205             


Gly Ala Ile Phe Gly Trp Gly Arg Asn Lys Phe Gly Gln Leu Gly Leu 
    210                 215                 220                 


Asn Asp Glu Asn Asp Arg Tyr Val Pro Asn Leu Leu Lys Ser Leu Arg 
225                 230                 235                 240 


Ser Gln Lys Ile Val Tyr Ile Cys Cys Gly Glu Asp His Thr Ala Ala 
                245                 250                 255     


Leu Thr Lys Glu Gly Gly Val Phe Thr Phe Gly Ala Gly Gly Tyr Gly 
            260                 265                 270         


Gln Leu Gly His Asn Ser Thr Ser His Glu Ile Asn Pro Arg Lys Val 
        275                 280                 285             


Phe Glu Leu Met Gly Ser Ile Val Thr Glu Ile Ala Cys Gly Arg Gln 
    290                 295                 300                 


His Thr Ser Ala Phe Val Pro Ser Ser Gly Arg Ile Tyr Ser Phe Gly 
305                 310                 315                 320 


Leu Gly Gly Asn Gly Gln Leu Gly Thr Gly Ser Thr Ser Asn Arg Lys 
                325                 330                 335     


Ser Pro Phe Thr Val Lys Gly Asn Trp Tyr Pro Tyr Asn Gly Gln Cys 
            340                 345                 350         


Leu Pro Asp Ile Asp Ser Glu Glu Tyr Phe Cys Val Lys Arg Ile Phe 
        355                 360                 365             


Ser Gly Gly Asp Gln Ser Phe Ser His Tyr Ser Ser Pro Gln Asn Cys 
    370                 375                 380                 


Gly Pro Pro Asp Asp Phe Arg Cys Pro Asn Pro Thr Lys Gln Ile Trp 
385                 390                 395                 400 


Thr Val Asn Glu Ala Leu Ile Gln Lys Trp Leu Ser Tyr Pro Ser Gly 
                405                 410                 415     


Arg Phe Pro Val Glu Ile Ala Asn Glu Ile Asp Gly Thr Phe Ser Ser 
            420                 425                 430         


Ser Gly Cys Leu Asn Gly Ser Phe Leu Ala Val Ser Asn Asp Asp His 
        435                 440                 445             


Tyr Arg Thr Gly Thr Arg Phe Ser Gly Val Asp Met Asn Ala Ala Arg 
    450                 455                 460                 


Leu Leu Phe His Lys Leu Ile Gln Pro Asp His Pro Gln Ile Ser Gln 
465                 470                 475                 480 


Gln Val Ala Ala Ser Leu Glu Lys Asn Leu Ile Pro Lys Leu Thr Ser 
                485                 490                 495     


Ser Leu Pro Asp Val Glu Ala Leu Arg Phe Tyr Leu Thr Leu Pro Glu 
            500                 505                 510         


Cys Pro Leu Met Ser Asp Ser Asn Asn Phe Thr Thr Ile Ala Ile Pro 
        515                 520                 525             


Phe Gly Thr Ala Leu Val Asn Leu Glu Lys Ala Pro Leu Lys Val Leu 
    530                 535                 540                 


Glu Asn Trp Trp Ser Val Leu Glu Pro Pro Leu Phe Leu Lys Ile Val 
545                 550                 555                 560 


Glu Leu Phe Lys Glu Val Val Val His Leu Leu Lys Leu Tyr Lys Ile 
                565                 570                 575     


Gly Ile Pro Pro Ser Glu Arg Arg Ile Phe Asn Ser Phe Leu His Thr 
            580                 585                 590         


Ala Leu Lys Val Leu Glu Ile Leu His Arg Val Asn Glu Lys Met Gly 
        595                 600                 605             


Gln Ile Ile Gln Tyr Asp Lys Phe Tyr Ile His Glu Val Gln Glu Leu 
    610                 615                 620                 


Ile Asp Ile Arg Asn Asp Tyr Ile Asn Trp Val Gln Gln Gln Ala Tyr 
625                 630                 635                 640 


Gly Met Asp Val Asn His Gly Leu Thr Glu Leu Ala Asp Ile Pro Val 
                645                 650                 655     


Thr Ile Cys Thr Tyr Pro Phe Val Phe Asp Ala Gln Ala Lys Thr Thr 
            660                 665                 670         


Leu Leu Gln Thr Asp Ala Val Leu Gln Met Gln Met Ala Ile Asp Gln 
        675                 680                 685             


Ala His Arg Gln Asn Val Ser Ser Leu Phe Leu Pro Val Ile Glu Ser 
    690                 695                 700                 


Val Asn Pro Cys Leu Ile Leu Val Val Arg Arg Glu Asn Ile Val Gly 
705                 710                 715                 720 


Asp Ala Met Glu Val Leu Arg Lys Thr Lys Asn Ile Asp Tyr Lys Lys 
                725                 730                 735     


Pro Leu Lys Val Ile Phe Val Gly Glu Asp Ala Val Asp Ala Gly Gly 
            740                 745                 750         


Val Arg Lys Glu Phe Phe Leu Leu Ile Met Arg Glu Leu Leu Asp Pro 
        755                 760                 765             


Lys Tyr Gly Met Phe Arg Tyr Tyr Glu Asp Ser Arg Leu Ile Trp Phe 
    770                 775                 780                 


Ser Asp Lys Thr Phe Glu Asp Ser Asp Leu Phe His Leu Ile Gly Val 
785                 790                 795                 800 


Ile Cys Gly Leu Ala Ile Tyr Asn Cys Thr Ile Val Asp Leu His Phe 
                805                 810                 815     


Pro Leu Ala Leu Tyr Lys Lys Leu Leu Lys Lys Lys Pro Ser Leu Asp 
            820                 825                 830         


Asp Leu Lys Glu Leu Met Pro Asp Val Gly Arg Ser Met Gln Gln Leu 
        835                 840                 845             


Leu Asp Tyr Pro Glu Asp Asp Ile Glu Glu Thr Phe Cys Leu Asn Phe 
    850                 855                 860                 


Thr Ile Thr Val Glu Asn Phe Gly Ala Thr Glu Val Lys Glu Leu Val 
865                 870                 875                 880 


Leu Asn Gly Ala Asp Thr Ala Val Asn Lys Gln Asn Arg Gln Glu Phe 
                885                 890                 895     


Val Asp Ala Tyr Val Asp Tyr Ile Phe Asn Lys Ser Val Ala Ser Leu 
            900                 905                 910         


Phe Asp Ala Phe His Ala Gly Phe His Lys Val Cys Gly Gly Lys Val 
        915                 920                 925             


Leu Leu Leu Phe Gln Pro Asn Glu Leu Gln Ala Met Val Ile Gly Asn 
    930                 935                 940                 


Thr Asn Tyr Asp Trp Lys Glu Leu Glu Lys Asn Thr Glu Tyr Lys Gly 
945                 950                 955                 960 


Glu Tyr Trp Ala Glu His Pro Thr Ile Lys Ile Phe Trp Glu Val Phe 
                965                 970                 975     


His Glu Leu Pro Leu Glu Lys Lys Lys Gln Phe Leu Leu Phe Leu Thr 
            980                 985                 990         


Gly Ser Asp Arg Ile Pro Ile Leu  Gly Met Lys Ser Leu  Lys Leu Val 
        995                 1000                 1005             


Ile Gln  Ser Thr Gly Gly Gly  Glu Glu Tyr Leu Pro  Val Ser His 
    1010                 1015                 1020             


Thr Cys  Phe Asn Leu Leu Asp  Leu Pro Lys Tyr Thr  Glu Lys Glu 
    1025                 1030                 1035             


Thr Leu  Arg Ser Lys Leu Ile  Gln Ala Ile Asp His  Asn Glu Gly 
    1040                 1045                 1050             


Phe Ser  Leu Ile 
    1055         


<210>  4875
<211>  608
<212>  PRT
<213>  Homo sapiens

<400>  4875

Met Gly Ser Val Thr Val Arg Tyr Phe Cys Tyr Gly Cys Leu Phe Thr 
1               5                   10                  15      


Ser Ala Thr Trp Thr Val Leu Leu Phe Val Tyr Phe Asn Phe Ser Glu 
            20                  25                  30          


Val Thr Gln Pro Leu Lys Asn Val Pro Val Lys Gly Ser Gly Pro His 
        35                  40                  45              


Gly Pro Ser Pro Lys Lys Phe Tyr Pro Arg Phe Thr Arg Gly Pro Ser 
    50                  55                  60                  


Arg Val Leu Glu Pro Gln Phe Lys Ala Asn Lys Ile Asp Asp Val Ile 
65                  70                  75                  80  


Asp Ser Arg Val Glu Asp Pro Glu Glu Gly His Leu Lys Phe Ser Ser 
                85                  90                  95      


Glu Leu Gly Met Ile Phe Asn Glu Arg Asp Gln Glu Leu Arg Asp Leu 
            100                 105                 110         


Gly Tyr Gln Lys His Ala Phe Asn Met Leu Ile Ser Asp Arg Leu Gly 
        115                 120                 125             


Tyr His Arg Asp Val Pro Asp Thr Arg Asn Ala Ala Cys Lys Glu Lys 
    130                 135                 140                 


Phe Tyr Pro Pro Asp Leu Pro Ala Ala Ser Val Val Ile Cys Phe Tyr 
145                 150                 155                 160 


Asn Glu Ala Phe Ser Ala Leu Leu Arg Thr Val His Ser Val Ile Asp 
                165                 170                 175     


Arg Thr Pro Ala His Leu Leu His Glu Ile Ile Leu Val Asp Asp Asp 
            180                 185                 190         


Ser Asp Phe Asp Asp Leu Lys Gly Glu Leu Asp Glu Tyr Val Gln Lys 
        195                 200                 205             


Tyr Leu Pro Gly Lys Ile Lys Val Ile Arg Asn Thr Lys Arg Glu Gly 
    210                 215                 220                 


Leu Ile Arg Gly Arg Met Ile Gly Ala Ala His Ala Thr Gly Glu Val 
225                 230                 235                 240 


Leu Val Phe Leu Asp Ser His Cys Glu Val Asn Val Met Trp Leu Gln 
                245                 250                 255     


Pro Leu Leu Ala Ala Ile Arg Glu Asp Arg His Thr Val Val Cys Pro 
            260                 265                 270         


Val Ile Asp Ile Ile Ser Ala Asp Thr Leu Ala Tyr Ser Ser Ser Pro 
        275                 280                 285             


Val Val Arg Gly Gly Phe Asn Trp Gly Leu His Phe Lys Trp Asp Leu 
    290                 295                 300                 


Val Pro Leu Ser Glu Leu Gly Arg Ala Glu Gly Ala Thr Ala Pro Ile 
305                 310                 315                 320 


Lys Ser Pro Thr Met Ala Gly Gly Leu Phe Ala Met Asn Arg Gln Tyr 
                325                 330                 335     


Phe His Glu Leu Gly Gln Tyr Asp Ser Gly Met Asp Ile Trp Gly Gly 
            340                 345                 350         


Glu Asn Leu Glu Ile Ser Phe Arg Ile Trp Met Cys Gly Gly Lys Leu 
        355                 360                 365             


Phe Ile Ile Pro Cys Ser Arg Val Gly His Ile Phe Arg Lys Arg Arg 
    370                 375                 380                 


Pro Tyr Gly Ser Pro Glu Gly Gln Asp Thr Met Thr His Asn Ser Leu 
385                 390                 395                 400 


Arg Leu Ala His Val Trp Leu Asp Glu Tyr Lys Glu Gln Tyr Phe Ser 
                405                 410                 415     


Leu Arg Pro Asp Leu Lys Thr Lys Ser Tyr Gly Asn Ile Ser Glu Arg 
            420                 425                 430         


Val Glu Leu Arg Lys Lys Leu Gly Cys Lys Ser Phe Lys Trp Tyr Leu 
        435                 440                 445             


Asp Asn Val Tyr Pro Glu Met Gln Ile Ser Gly Ser His Ala Lys Pro 
    450                 455                 460                 


Gln Gln Pro Ile Phe Val Asn Arg Gly Pro Lys Arg Pro Lys Val Leu 
465                 470                 475                 480 


Gln Arg Gly Arg Leu Tyr His Leu Gln Thr Asn Lys Cys Leu Val Ala 
                485                 490                 495     


Gln Gly Arg Pro Ser Gln Lys Gly Gly Leu Val Val Leu Lys Ala Cys 
            500                 505                 510         


Asp Tyr Ser Asp Pro Asn Gln Ile Trp Ile Tyr Asn Glu Glu His Glu 
        515                 520                 525             


Leu Val Leu Asn Ser Leu Leu Cys Leu Asp Met Ser Glu Thr Arg Ser 
    530                 535                 540                 


Ser Asp Pro Pro Arg Leu Met Lys Cys His Gly Ser Gly Gly Ser Gln 
545                 550                 555                 560 


Gln Trp Thr Phe Gly Lys Asn Asn Arg Leu Tyr Gln Val Ser Val Gly 
                565                 570                 575     


Gln Cys Leu Arg Ala Val Asp Pro Leu Gly Gln Lys Gly Ser Val Ala 
            580                 585                 590         


Met Ala Ile Cys Asp Gly Ser Ser Ser Gln Gln Trp His Leu Glu Gly 
        595                 600                 605             


<210>  4876
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  4876

Met Ile Arg Cys Gly Leu Ala Cys Glu Arg Cys Arg Trp Ile Leu Pro 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ala Ile Ala Phe Asp Ile Ile Ala Leu Ala Gly 
            20                  25                  30          


Arg Gly Trp Leu Gln Ser Ser Asp His Gly Gln Thr Ser Ser Leu Trp 
        35                  40                  45              


Trp Lys Cys Ser Gln Glu Gly Gly Gly Ser Gly Ser Tyr Glu Glu Gly 
    50                  55                  60                  


Cys Gln Ser Leu Met Glu Tyr Ala Trp Gly Arg Ala Ala Ala Ala Met 
65                  70                  75                  80  


Leu Phe Cys Gly Phe Ile Ile Leu Val Ile Cys Phe Ile Leu Ser Phe 
                85                  90                  95      


Phe Ala Leu Cys Gly Pro Gln Met Leu Val Phe Leu Arg Val Ile Gly 
            100                 105                 110         


Gly Leu Leu Ala Leu Ala Ala Val Phe Gln Ile Ile Ser Leu Val Ile 
        115                 120                 125             


Tyr Pro Val Lys Tyr Thr Gln Thr Phe Thr Leu His Ala Asn Pro Ala 
    130                 135                 140                 


Val Thr Tyr Ile Tyr Asn Trp Ala Tyr Gly Phe Gly Trp Ala Ala Thr 
145                 150                 155                 160 


Ile Ile Leu Ile Gly Cys Ala Phe Phe Phe Cys Cys Leu Pro Asn Tyr 
                165                 170                 175     


Glu Asp Asp Leu Leu Gly Asn Ala Lys Pro Arg Tyr Phe Tyr Thr Ser 
            180                 185                 190         


Ala 
    


<210>  4877
<211>  3354
<212>  PRT
<213>  Homo sapiens

<400>  4877

Met Gly Arg His Val Ala Thr Ser Cys His Val Ala Trp Leu Leu Val 
1               5                   10                  15      


Leu Ile Ser Gly Cys Trp Gly Gln Val Asn Arg Leu Pro Phe Phe Thr 
            20                  25                  30          


Asn His Phe Phe Asp Thr Tyr Leu Leu Ile Ser Glu Asp Thr Pro Val 
        35                  40                  45              


Gly Ser Ser Val Thr Gln Leu Leu Ala Gln Asp Met Asp Asn Asp Pro 
    50                  55                  60                  


Leu Val Phe Gly Val Ser Gly Glu Glu Ala Ser Arg Phe Phe Ala Val 
65                  70                  75                  80  


Glu Pro Asp Thr Gly Val Val Trp Leu Arg Gln Pro Leu Asp Arg Glu 
                85                  90                  95      


Thr Lys Ser Glu Phe Thr Val Glu Phe Ser Val Ser Asp His Gln Gly 
            100                 105                 110         


Val Ile Thr Arg Lys Val Asn Ile Gln Val Gly Asp Val Asn Asp Asn 
        115                 120                 125             


Ala Pro Thr Phe His Asn Gln Pro Tyr Ser Val Arg Ile Pro Glu Asn 
    130                 135                 140                 


Thr Pro Val Gly Thr Pro Ile Phe Ile Val Asn Ala Thr Asp Pro Asp 
145                 150                 155                 160 


Leu Gly Ala Gly Gly Ser Val Leu Tyr Ser Phe Gln Pro Pro Ser Gln 
                165                 170                 175     


Phe Phe Ala Ile Asp Ser Ala Arg Gly Ile Val Thr Val Ile Arg Glu 
            180                 185                 190         


Leu Asp Tyr Glu Thr Thr Gln Ala Tyr Gln Leu Thr Val Asn Ala Thr 
        195                 200                 205             


Asp Gln Asp Lys Thr Arg Pro Leu Ser Thr Leu Ala Asn Leu Ala Ile 
    210                 215                 220                 


Ile Ile Thr Asp Val Gln Asp Met Asp Pro Ile Phe Ile Asn Leu Pro 
225                 230                 235                 240 


Tyr Ser Thr Asn Ile Tyr Glu His Ser Pro Pro Gly Thr Thr Val Arg 
                245                 250                 255     


Ile Ile Thr Ala Ile Asp Gln Asp Lys Gly Arg Pro Arg Gly Ile Gly 
            260                 265                 270         


Tyr Thr Ile Val Ser Gly Asn Thr Asn Ser Ile Phe Ala Leu Asp Tyr 
        275                 280                 285             


Ile Ser Gly Val Leu Thr Leu Asn Gly Leu Leu Asp Arg Glu Asn Pro 
    290                 295                 300                 


Leu Tyr Ser His Gly Phe Ile Leu Thr Val Lys Gly Thr Glu Leu Asn 
305                 310                 315                 320 


Asp Asp Arg Thr Pro Ser Asp Ala Thr Val Thr Thr Thr Phe Asn Ile 
                325                 330                 335     


Leu Val Ile Asp Ile Asn Asp Asn Ala Pro Glu Phe Asn Ser Ser Glu 
            340                 345                 350         


Tyr Ser Val Ala Ile Thr Glu Leu Ala Gln Val Gly Phe Ala Leu Pro 
        355                 360                 365             


Leu Phe Ile Gln Val Val Asp Lys Asp Glu Asn Leu Gly Leu Asn Ser 
    370                 375                 380                 


Met Phe Glu Val Tyr Leu Val Gly Asn Asn Ser His His Phe Ile Ile 
385                 390                 395                 400 


Ser Pro Thr Ser Val Gln Gly Lys Ala Asp Ile Arg Ile Arg Val Ala 
                405                 410                 415     


Ile Pro Leu Asp Tyr Glu Thr Val Asp Arg Tyr Asp Phe Asp Leu Phe 
            420                 425                 430         


Ala Asn Glu Ser Val Pro Asp His Val Gly Tyr Ala Lys Val Lys Ile 
        435                 440                 445             


Thr Leu Ile Asn Glu Asn Asp Asn Arg Pro Ile Phe Ser Gln Pro Leu 
    450                 455                 460                 


Tyr Asn Ile Ser Leu Tyr Glu Asn Val Thr Val Gly Thr Ser Val Leu 
465                 470                 475                 480 


Thr Val Leu Ala Thr Asp Asn Asp Ala Gly Thr Phe Gly Glu Val Ser 
                485                 490                 495     


Tyr Phe Phe Ser Asp Asp Pro Asp Arg Phe Ser Leu Asp Lys Asp Thr 
            500                 505                 510         


Gly Leu Ile Met Leu Ile Ala Arg Leu Asp Tyr Glu Leu Ile Gln Arg 
        515                 520                 525             


Phe Thr Leu Thr Ile Ile Ala Arg Asp Gly Gly Gly Glu Glu Thr Thr 
    530                 535                 540                 


Gly Arg Val Arg Ile Asn Val Leu Asp Val Asn Asp Asn Val Pro Thr 
545                 550                 555                 560 


Phe Gln Lys Asp Ala Tyr Val Gly Ala Leu Arg Glu Asn Glu Pro Ser 
                565                 570                 575     


Val Thr Gln Leu Val Arg Leu Arg Ala Thr Asp Glu Asp Ser Pro Pro 
            580                 585                 590         


Asn Asn Gln Ile Thr Tyr Ser Ile Val Ser Ala Ser Ala Phe Gly Ser 
        595                 600                 605             


Tyr Phe Asp Ile Ser Leu Tyr Glu Gly Tyr Gly Val Ile Ser Val Ser 
    610                 615                 620                 


Arg Pro Leu Asp Tyr Glu Gln Ile Ser Asn Gly Leu Ile Tyr Leu Thr 
625                 630                 635                 640 


Val Met Ala Met Asp Ala Gly Asn Pro Pro Leu Asn Ser Thr Val Pro 
                645                 650                 655     


Val Thr Ile Glu Val Phe Asp Glu Asn Asp Asn Pro Pro Thr Phe Ser 
            660                 665                 670         


Lys Pro Ala Tyr Phe Val Ser Val Val Glu Asn Ile Met Ala Gly Ala 
        675                 680                 685             


Thr Val Leu Phe Leu Asn Ala Thr Asp Leu Asp Arg Ser Arg Glu Tyr 
    690                 695                 700                 


Gly Gln Glu Ser Ile Ile Tyr Ser Leu Glu Gly Ser Thr Gln Phe Arg 
705                 710                 715                 720 


Ile Asn Ala Arg Ser Gly Glu Ile Thr Thr Thr Ser Leu Leu Asp Arg 
                725                 730                 735     


Glu Thr Lys Ser Glu Tyr Ile Leu Ile Val Arg Ala Val Asp Gly Gly 
            740                 745                 750         


Val Gly His Asn Gln Lys Thr Gly Ile Ala Thr Val Asn Ile Thr Leu 
        755                 760                 765             


Leu Asp Ile Asn Asp Asn His Pro Thr Trp Lys Asp Ala Pro Tyr Tyr 
    770                 775                 780                 


Ile Asn Leu Val Glu Met Thr Pro Pro Asp Ser Asp Val Thr Thr Val 
785                 790                 795                 800 


Val Ala Val Asp Pro Asp Leu Gly Glu Asn Gly Thr Leu Val Tyr Ser 
                805                 810                 815     


Ile Gln Pro Pro Asn Lys Phe Tyr Ser Leu Asn Ser Thr Thr Gly Lys 
            820                 825                 830         


Ile Arg Thr Thr His Ala Met Leu Asp Arg Glu Asn Pro Asp Pro His 
        835                 840                 845             


Glu Ala Glu Leu Met Arg Lys Ile Val Val Ser Val Thr Asp Cys Gly 
    850                 855                 860                 


Arg Pro Pro Leu Lys Ala Thr Ser Ser Ala Thr Val Phe Val Asn Leu 
865                 870                 875                 880 


Leu Asp Leu Asn Asp Asn Asp Pro Thr Phe Gln Asn Leu Pro Phe Val 
                885                 890                 895     


Ala Glu Val Leu Glu Gly Ile Pro Ala Gly Val Ser Ile Tyr Gln Val 
            900                 905                 910         


Val Ala Ile Asp Leu Asp Glu Gly Leu Asn Gly Leu Val Ser Tyr Arg 
        915                 920                 925             


Met Pro Val Gly Met Pro Arg Met Asp Phe Leu Ile Asn Ser Ser Ser 
    930                 935                 940                 


Gly Val Val Val Thr Thr Thr Glu Leu Asp Arg Glu Arg Ile Ala Glu 
945                 950                 955                 960 


Tyr Gln Leu Arg Val Val Ala Ser Asp Ala Gly Thr Pro Thr Lys Ser 
                965                 970                 975     


Ser Thr Ser Thr Leu Thr Ile His Val Leu Asp Val Asn Asp Glu Thr 
            980                 985                 990         


Pro Thr Phe Phe Pro Ala Val Tyr  Asn Val Ser Val Ser  Glu Asp Val 
        995                 1000                 1005             


Pro Arg  Glu Phe Arg Val Val  Trp Leu Asn Cys Thr  Asp Asn Asp 
    1010                 1015                 1020             


Val Gly  Leu Asn Ala Glu Leu  Ser Tyr Phe Ile Thr  Gly Gly Asn 
    1025                 1030                 1035             


Val Asp  Gly Lys Phe Ser Val  Gly Tyr Arg Asp Ala  Val Val Arg 
    1040                 1045                 1050             


Thr Val  Val Gly Leu Asp Arg  Glu Thr Thr Ala Ala  Tyr Met Leu 
    1055                 1060                 1065             


Ile Leu  Glu Ala Ile Asp Asn  Gly Pro Val Gly Lys  Arg His Thr 
    1070                 1075                 1080             


Gly Thr  Ala Thr Val Phe Val  Thr Val Leu Asp Val  Asn Asp Asn 
    1085                 1090                 1095             


Arg Pro  Ile Phe Leu Gln Ser  Ser Tyr Glu Ala Ser  Val Pro Glu 
    1100                 1105                 1110             


Asp Ile  Pro Glu Gly His Ser  Ile Leu Gln Leu Lys  Ala Thr Asp 
    1115                 1120                 1125             


Ala Asp  Glu Gly Glu Phe Gly  Arg Val Trp Tyr Arg  Ile Leu His 
    1130                 1135                 1140             


Gly Asn  His Gly Asn Asn Phe  Arg Ile His Val Ser  Asn Gly Leu 
    1145                 1150                 1155             


Leu Met  Arg Gly Pro Arg Pro  Leu Asp Arg Glu Arg  Asn Ser Ser 
    1160                 1165                 1170             


His Val  Leu Ile Val Glu Ala  Tyr Asn His Asp Leu  Gly Pro Met 
    1175                 1180                 1185             


Arg Ser  Ser Val Arg Val Ile  Val Tyr Val Glu Asp  Ile Asn Asp 
    1190                 1195                 1200             


Glu Ala  Pro Val Phe Thr Gln  Gln Gln Tyr Ser Arg  Leu Gly Leu 
    1205                 1210                 1215             


Arg Glu  Thr Ala Gly Ile Gly  Thr Ser Val Ile Val  Val Gln Ala 
    1220                 1225                 1230             


Thr Asp  Arg Asp Ser Gly Asp  Gly Gly Leu Val Asn  Tyr Arg Ile 
    1235                 1240                 1245             


Leu Ser  Gly Ala Glu Gly Lys  Phe Glu Ile Asp Glu  Ser Thr Gly 
    1250                 1255                 1260             


Leu Ile  Ile Thr Val Asn Tyr  Leu Asp Tyr Glu Thr  Lys Thr Ser 
    1265                 1270                 1275             


Tyr Met  Met Asn Val Ser Ala  Thr Asp Gln Ala Pro  Pro Phe Asn 
    1280                 1285                 1290             


Gln Gly  Phe Cys Ser Val Tyr  Ile Thr Leu Leu Asn  Glu Leu Asp 
    1295                 1300                 1305             


Glu Ala  Val Gln Phe Ser Asn  Ala Ser Tyr Glu Ala  Ala Ile Leu 
    1310                 1315                 1320             


Glu Asn  Leu Ala Leu Gly Thr  Glu Ile Val Arg Val  Gln Ala Tyr 
    1325                 1330                 1335             


Ser Ile  Asp Asn Leu Asn Gln  Ile Thr Tyr Arg Phe  Asn Ala Tyr 
    1340                 1345                 1350             


Thr Ser  Thr Gln Ala Lys Ala  Leu Phe Lys Ile Asp  Ala Ile Thr 
    1355                 1360                 1365             


Gly Val  Ile Thr Val Gln Gly  Leu Val Asp Arg Glu  Lys Gly Asp 
    1370                 1375                 1380             


Phe Tyr  Thr Leu Thr Val Val  Ala Asp Asp Gly Gly  Pro Lys Val 
    1385                 1390                 1395             


Asp Ser  Thr Val Lys Val Tyr  Ile Thr Val Leu Asp  Glu Asn Asp 
    1400                 1405                 1410             


Asn Ser  Pro Arg Phe Asp Phe  Thr Ser Asp Ser Ala  Val Ser Ile 
    1415                 1420                 1425             


Pro Glu  Asp Cys Pro Val Gly  Gln Arg Val Ala Thr  Val Lys Ala 
    1430                 1435                 1440             


Trp Asp  Pro Asp Ala Gly Ser  Asn Gly Gln Val Val  Phe Ser Leu 
    1445                 1450                 1455             


Ala Ser  Gly Asn Ile Ala Gly  Ala Phe Glu Ile Val  Thr Thr Asn 
    1460                 1465                 1470             


Asp Ser  Ile Gly Glu Val Phe  Val Ala Arg Pro Leu  Asp Arg Glu 
    1475                 1480                 1485             


Glu Leu  Asp His Tyr Ile Leu  Gln Val Val Ala Ser  Asp Arg Gly 
    1490                 1495                 1500             


Thr Pro  Pro Arg Lys Lys Asp  His Ile Leu Gln Val  Thr Ile Leu 
    1505                 1510                 1515             


Asp Ile  Asn Asp Asn Pro Pro  Val Ile Glu Ser Pro  Phe Gly Tyr 
    1520                 1525                 1530             


Asn Val  Ser Val Asn Glu Asn  Val Gly Gly Gly Thr  Ala Val Val 
    1535                 1540                 1545             


Gln Val  Arg Ala Thr Asp Arg  Asp Ile Gly Ile Asn  Ser Val Leu 
    1550                 1555                 1560             


Ser Tyr  Tyr Ile Thr Glu Gly  Asn Lys Asp Met Ala  Phe Arg Met 
    1565                 1570                 1575             


Asp Arg  Ile Ser Gly Glu Ile  Ala Thr Arg Pro Ala  Pro Pro Asp 
    1580                 1585                 1590             


Arg Glu  Arg Gln Ser Phe Tyr  His Leu Val Ala Thr  Val Glu Asp 
    1595                 1600                 1605             


Glu Gly  Thr Pro Thr Leu Ser  Ala Thr Thr His Val  Tyr Val Thr 
    1610                 1615                 1620             


Ile Val  Asp Glu Asn Asp Asn  Ala Pro Met Phe Gln  Gln Pro His 
    1625                 1630                 1635             


Tyr Glu  Val Leu Leu Asp Glu  Gly Pro Asp Thr Leu  Asn Thr Ser 
    1640                 1645                 1650             


Leu Ile  Thr Ile Gln Ala Leu  Asp Leu Asp Glu Gly  Pro Asn Gly 
    1655                 1660                 1665             


Thr Val  Thr Tyr Ala Ile Val  Ala Gly Asn Ile Val  Asn Thr Phe 
    1670                 1675                 1680             


Arg Ile  Asp Arg His Met Gly  Val Ile Thr Ala Ala  Lys Glu Leu 
    1685                 1690                 1695             


Asp Tyr  Glu Ile Ser His Gly  Arg Tyr Thr Leu Ile  Val Thr Ala 
    1700                 1705                 1710             


Thr Asp  Gln Cys Pro Ile Leu  Ser His Arg Leu Thr  Ser Thr Thr 
    1715                 1720                 1725             


Thr Val  Leu Val Asn Val Asn  Asp Ile Asn Asp Asn  Val Pro Thr 
    1730                 1735                 1740             


Phe Pro  Arg Asp Tyr Glu Gly  Pro Phe Glu Val Thr  Glu Gly Gln 
    1745                 1750                 1755             


Pro Gly  Pro Arg Val Trp Thr  Phe Leu Ala His Asp  Arg Asp Ser 
    1760                 1765                 1770             


Gly Pro  Asn Gly Gln Val Glu  Tyr Ser Ile Met Asp  Gly Asp Pro 
    1775                 1780                 1785             


Leu Gly  Glu Phe Val Ile Ser  Pro Val Glu Gly Val  Leu Arg Val 
    1790                 1795                 1800             


Arg Lys  Asp Val Glu Leu Asp  Arg Glu Thr Ile Ala  Phe Tyr Asn 
    1805                 1810                 1815             


Leu Thr  Ile Cys Ala Arg Asp  Arg Gly Met Pro Pro  Leu Ser Ser 
    1820                 1825                 1830             


Thr Met  Leu Val Gly Ile Arg  Val Leu Asp Ile Asn  Asp Asn Asp 
    1835                 1840                 1845             


Pro Val  Leu Leu Asn Leu Pro  Met Asn Ile Thr Ile  Ser Glu Asn 
    1850                 1855                 1860             


Ser Pro  Val Ser Ser Phe Val  Ala His Val Leu Ala  Ser Asp Ala 
    1865                 1870                 1875             


Asp Ser  Gly Cys Asn Ala Arg  Leu Thr Phe Asn Ile  Thr Ala Gly 
    1880                 1885                 1890             


Asn Arg  Glu Arg Ala Phe Phe  Ile Asn Ala Thr Thr  Gly Ile Val 
    1895                 1900                 1905             


Thr Val  Asn Arg Pro Leu Asp  Arg Glu Arg Ile Pro  Glu Tyr Lys 
    1910                 1915                 1920             


Leu Thr  Ile Ser Val Lys Asp  Asn Pro Glu Asn Pro  Arg Ile Ala 
    1925                 1930                 1935             


Arg Arg  Asp Tyr Asp Leu Leu  Leu Ile Phe Leu Ser  Asp Glu Asn 
    1940                 1945                 1950             


Asp Asn  His Pro Leu Phe Thr  Lys Ser Thr Tyr Gln  Ala Glu Val 
    1955                 1960                 1965             


Met Glu  Asn Ser Pro Ala Gly  Thr Pro Leu Thr Val  Leu Asn Gly 
    1970                 1975                 1980             


Pro Ile  Leu Ala Leu Asp Ala  Asp Gln Asp Ile Tyr  Ala Val Val 
    1985                 1990                 1995             


Thr Tyr  Gln Leu Leu Gly Ala  Gln Ser Gly Leu Phe  Asp Ile Asn 
    2000                 2005                 2010             


Ser Ser  Thr Gly Val Val Thr  Val Arg Ser Gly Val  Ile Ile Asp 
    2015                 2020                 2025             


Arg Glu  Ala Phe Ser Pro Pro  Ile Leu Glu Leu Leu  Leu Leu Ala 
    2030                 2035                 2040             


Glu Asp  Ile Gly Leu Leu Asn  Ser Thr Ala His Leu  Leu Ile Thr 
    2045                 2050                 2055             


Ile Leu  Asp Asp Asn Asp Asn  Arg Pro Thr Phe Ser  Pro Ala Thr 
    2060                 2065                 2070             


Leu Thr  Val His Leu Leu Glu  Asn Cys Pro Pro Gly  Phe Ser Val 
    2075                 2080                 2085             


Leu Gln  Val Thr Ala Thr Asp  Glu Asp Ser Gly Leu  Asn Gly Glu 
    2090                 2095                 2100             


Leu Val  Tyr Arg Ile Glu Ala  Gly Ala Gln Asp Arg  Phe Leu Ile 
    2105                 2110                 2115             


His Leu  Val Thr Gly Val Ile  Arg Val Gly Asn Ala  Thr Ile Asp 
    2120                 2125                 2130             


Arg Glu  Glu Gln Glu Ser Tyr  Arg Leu Thr Val Val  Ala Thr Asp 
    2135                 2140                 2145             


Arg Gly  Thr Val Pro Leu Ser  Gly Thr Ala Ile Val  Thr Ile Leu 
    2150                 2155                 2160             


Ile Asp  Asp Ile Asn Asp Ser  Arg Pro Glu Phe Leu  Asn Pro Ile 
    2165                 2170                 2175             


Gln Thr  Val Ser Val Leu Glu  Ser Ala Glu Pro Gly  Thr Val Ile 
    2180                 2185                 2190             


Ala Asn  Ile Thr Ala Ile Asp  His Asp Leu Asn Pro  Lys Leu Glu 
    2195                 2200                 2205             


Tyr His  Ile Val Gly Ile Val  Ala Lys Asp Asp Thr  Asp Arg Leu 
    2210                 2215                 2220             


Val Pro  Asn Gln Glu Asp Ala  Phe Ala Val Asn Ile  Asn Thr Gly 
    2225                 2230                 2235             


Ser Val  Met Val Lys Ser Pro  Met Asn Arg Glu Leu  Val Ala Thr 
    2240                 2245                 2250             


Tyr Glu  Val Thr Leu Ser Val  Ile Asp Asn Ala Ser  Asp Leu Pro 
    2255                 2260                 2265             


Glu Arg  Ser Val Ser Val Pro  Asn Ala Lys Leu Thr  Val Asn Val 
    2270                 2275                 2280             


Leu Asp  Val Asn Asp Asn Thr  Pro Gln Phe Lys Pro  Phe Gly Ile 
    2285                 2290                 2295             


Thr Tyr  Tyr Met Glu Arg Ile  Leu Glu Gly Ala Thr  Pro Gly Thr 
    2300                 2305                 2310             


Thr Leu  Ile Ala Val Ala Ala  Val Asp Pro Asp Lys  Gly Leu Asn 
    2315                 2320                 2325             


Gly Leu  Val Thr Tyr Thr Leu  Leu Asp Leu Val Pro  Pro Gly Tyr 
    2330                 2335                 2340             


Val Gln  Leu Glu Asp Ser Ser  Ala Gly Lys Val Ile  Ala Asn Arg 
    2345                 2350                 2355             


Thr Val  Asp Tyr Glu Glu Val  His Trp Leu Asn Phe  Thr Val Arg 
    2360                 2365                 2370             


Ala Ser  Asp Asn Gly Ser Pro  Pro Arg Ala Ala Glu  Ile Pro Val 
    2375                 2380                 2385             


Tyr Leu  Glu Ile Val Asp Ile  Asn Asp Asn Asn Pro  Ile Phe Asp 
    2390                 2395                 2400             


Gln Pro  Ser Tyr Gln Glu Ala  Val Phe Glu Asp Val  Pro Val Gly 
    2405                 2410                 2415             


Thr Ile  Ile Leu Thr Val Thr  Ala Thr Asp Ala Asp  Ser Gly Asn 
    2420                 2425                 2430             


Phe Ala  Leu Ile Glu Tyr Ser  Leu Gly Asp Gly Glu  Ser Lys Phe 
    2435                 2440                 2445             


Ala Ile  Asn Pro Thr Thr Gly  Asp Ile Tyr Val Leu  Ser Ser Leu 
    2450                 2455                 2460             


Asp Arg  Glu Lys Lys Asp His  Tyr Ile Leu Thr Ala  Leu Ala Lys 
    2465                 2470                 2475             


Asp Asn  Pro Gly Asp Val Ala  Ser Asn Arg Arg Glu  Asn Ser Val 
    2480                 2485                 2490             


Gln Val  Val Ile Gln Val Leu  Asp Val Asn Asp Cys  Arg Pro Gln 
    2495                 2500                 2505             


Phe Ser  Lys Pro Gln Phe Ser  Thr Ser Val Tyr Glu  Asn Glu Pro 
    2510                 2515                 2520             


Ala Gly  Thr Ser Val Ile Thr  Met Met Ala Thr Asp  Gln Asp Glu 
    2525                 2530                 2535             


Gly Pro  Asn Gly Glu Leu Thr  Tyr Ser Leu Glu Gly  Pro Gly Val 
    2540                 2545                 2550             


Glu Ala  Phe His Val Asp Met  Asp Ser Gly Leu Val  Thr Thr Gln 
    2555                 2560                 2565             


Arg Pro  Leu Gln Ser Tyr Glu  Lys Phe Ser Leu Thr  Val Val Ala 
    2570                 2575                 2580             


Thr Asp  Gly Gly Glu Pro Pro  Leu Trp Gly Thr Thr  Met Leu Leu 
    2585                 2590                 2595             


Val Glu  Val Ile Asp Val Asn  Asp Asn Arg Pro Val  Phe Val Arg 
    2600                 2605                 2610             


Pro Pro  Asn Gly Thr Ile Leu  His Ile Arg Glu Glu  Ile Pro Leu 
    2615                 2620                 2625             


Arg Ser  Asn Val Tyr Glu Val  Tyr Ala Thr Asp Lys  Asp Glu Gly 
    2630                 2635                 2640             


Leu Asn  Gly Ala Val Arg Tyr  Ser Phe Leu Lys Thr  Ala Gly Asn 
    2645                 2650                 2655             


Arg Asp  Trp Glu Phe Phe Ile  Ile Asp Pro Ile Ser  Gly Leu Ile 
    2660                 2665                 2670             


Gln Thr  Ala Gln Arg Leu Asp  Arg Glu Ser Gln Ala  Val Tyr Ser 
    2675                 2680                 2685             


Leu Ile  Leu Val Ala Ser Asp  Leu Gly Gln Pro Val  Pro Tyr Glu 
    2690                 2695                 2700             


Thr Met  Gln Pro Leu Gln Val  Ala Leu Glu Asp Ile  Asp Asp Asn 
    2705                 2710                 2715             


Glu Pro  Leu Phe Val Arg Pro  Pro Lys Gly Ser Pro  Gln Tyr Gln 
    2720                 2725                 2730             


Leu Leu  Thr Val Pro Glu His  Ser Pro Arg Gly Thr  Leu Val Gly 
    2735                 2740                 2745             


Asn Val  Thr Gly Ala Val Asp  Ala Asp Glu Gly Pro  Asn Ala Ile 
    2750                 2755                 2760             


Val Tyr  Tyr Phe Ile Ala Ala  Gly Asn Glu Glu Lys  Asn Phe His 
    2765                 2770                 2775             


Leu Gln  Pro Asp Gly Cys Leu  Leu Val Leu Arg Asp  Leu Asp Arg 
    2780                 2785                 2790             


Glu Arg  Glu Ala Ile Phe Ser  Phe Ile Val Lys Ala  Ser Ser Asn 
    2795                 2800                 2805             


Arg Ser  Trp Thr Pro Pro Arg  Gly Pro Ser Pro Thr  Leu Asp Leu 
    2810                 2815                 2820             


Val Ala  Asp Leu Thr Leu Gln  Glu Val Arg Val Val  Leu Glu Asp 
    2825                 2830                 2835             


Ile Asn  Asp Gln Pro Pro Arg  Phe Thr Lys Ala Glu  Tyr Thr Ala 
    2840                 2845                 2850             


Gly Val  Ala Thr Asp Ala Lys  Val Gly Ser Glu Leu  Ile Gln Val 
    2855                 2860                 2865             


Leu Ala  Leu Asp Ala Asp Ile  Gly Asn Asn Ser Leu  Val Phe Tyr 
    2870                 2875                 2880             


Ser Ile  Leu Ala Ile His Tyr  Phe Arg Ala Leu Ala  Asn Asp Ser 
    2885                 2890                 2895             


Glu Asp  Val Gly Gln Val Phe  Thr Met Gly Ser Met  Asp Gly Ile 
    2900                 2905                 2910             


Leu Arg  Thr Phe Asp Leu Phe  Met Ala Tyr Ser Pro  Gly Tyr Phe 
    2915                 2920                 2925             


Val Val  Asp Ile Val Ala Arg  Asp Leu Ala Gly His  Asn Asp Thr 
    2930                 2935                 2940             


Ala Ile  Ile Gly Ile Tyr Ile  Leu Arg Asp Asp Gln  Arg Val Lys 
    2945                 2950                 2955             


Ile Val  Ile Asn Glu Ile Pro  Asp Arg Val Arg Gly  Phe Glu Glu 
    2960                 2965                 2970             


Glu Phe  Ile His Leu Leu Ser  Asn Ile Thr Gly Ala  Ile Val Asn 
    2975                 2980                 2985             


Thr Asp  Asn Val Gln Phe His  Val Asp Lys Lys Gly  Arg Val Asn 
    2990                 2995                 3000             


Phe Ala  Gln Thr Glu Leu Leu  Ile His Val Val Asn  Arg Asp Thr 
    3005                 3010                 3015             


Asn Arg  Ile Leu Asp Val Asp  Arg Val Ile Gln Met  Ile Asp Glu 
    3020                 3025                 3030             


Asn Lys  Glu Gln Leu Arg Asn  Leu Phe Arg Asn Tyr  Asn Val Leu 
    3035                 3040                 3045             


Asp Val  Gln Pro Ala Ile Ser  Val Arg Leu Pro Asp  Asp Met Ser 
    3050                 3055                 3060             


Ala Leu  Gln Met Ala Ile Ile  Val Leu Ala Ile Leu  Leu Phe Leu 
    3065                 3070                 3075             


Ala Ala  Met Leu Phe Val Leu  Met Asn Trp Tyr Tyr  Arg Thr Val 
    3080                 3085                 3090             


His Lys  Arg Lys Leu Lys Ala  Ile Val Ala Gly Ser  Ala Gly Asn 
    3095                 3100                 3105             


Arg Gly  Phe Ile Asp Ile Met  Asp Met Pro Asn Thr  Asn Lys Tyr 
    3110                 3115                 3120             


Ser Phe  Asp Gly Ala Asn Pro  Val Trp Leu Asp Pro  Phe Cys Arg 
    3125                 3130                 3135             


Asn Leu  Glu Leu Ala Ala Gln  Ala Glu His Glu Asp  Asp Leu Pro 
    3140                 3145                 3150             


Glu Asn  Leu Ser Glu Ile Ala  Asp Leu Trp Asn Ser  Pro Thr Arg 
    3155                 3160                 3165             


Thr His  Gly Thr Phe Gly Arg  Glu Pro Ala Ala Val  Lys Pro Asp 
    3170                 3175                 3180             


Asp Asp  Arg Tyr Leu Arg Ala  Ala Ile Gln Glu Tyr  Asp Asn Ile 
    3185                 3190                 3195             


Ala Lys  Leu Gly Gln Ile Ile  Arg Glu Gly Pro Ile  Lys Gly Ser 
    3200                 3205                 3210             


Leu Leu  Lys Val Val Leu Glu  Asp Tyr Leu Arg Leu  Lys Lys Leu 
    3215                 3220                 3225             


Phe Ala  Gln Arg Met Val Gln  Lys Ala Ser Ser Cys  His Ser Ser 
    3230                 3235                 3240             


Ile Ser  Glu Leu Ile Gln Thr  Glu Leu Asp Glu Glu  Pro Gly Asp 
    3245                 3250                 3255             


His Ser  Pro Gly Gln Gly Ser  Leu Arg Phe Arg His  Lys Pro Pro 
    3260                 3265                 3270             


Val Glu  Leu Lys Gly Pro Asp  Gly Ile His Val Val  His Gly Ser 
    3275                 3280                 3285             


Thr Gly  Thr Leu Leu Ala Thr  Asp Leu Asn Ser Leu  Pro Glu Glu 
    3290                 3295                 3300             


Asp Gln  Lys Gly Leu Gly Arg  Ser Leu Glu Thr Leu  Thr Ala Ala 
    3305                 3310                 3315             


Glu Ala  Thr Ala Phe Glu Arg  Asn Ala Arg Thr Glu  Ser Ala Lys 
    3320                 3325                 3330             


Ser Thr  Pro Leu His Lys Leu  Arg Asp Val Ile Met  Glu Thr Pro 
    3335                 3340                 3345             


Leu Glu  Ile Thr Glu Leu 
    3350                 


<210>  4878
<211>  691
<212>  PRT
<213>  Homo sapiens

<400>  4878

Met Glu Leu Arg Ser Thr Ala Ala Pro Arg Ala Glu Gly Tyr Ser Asn 
1               5                   10                  15      


Val Gly Phe Gln Asn Glu Glu Asn Phe Leu Glu Asn Glu Asn Thr Ser 
            20                  25                  30          


Gly Asn Asn Ser Ile Arg Ser Arg Ala Val Gln Ser Arg Glu His Thr 
        35                  40                  45              


Asn Thr Lys Gln Asp Glu Glu Gln Val Thr Val Glu Gln Asp Ser Pro 
    50                  55                  60                  


Arg Asn Arg Glu His Met Glu Asp Asp Asp Glu Glu Met Gln Gln Lys 
65                  70                  75                  80  


Gly Cys Leu Glu Arg Arg Tyr Asp Thr Val Cys Gly Phe Cys Arg Lys 
                85                  90                  95      


His Lys Thr Thr Leu Arg His Ile Ile Trp Gly Ile Leu Leu Ala Gly 
            100                 105                 110         


Tyr Leu Val Met Val Ile Ser Ala Cys Val Leu Asn Phe His Arg Ala 
        115                 120                 125             


Leu Pro Leu Phe Val Ile Thr Val Ala Ala Ile Phe Phe Val Val Trp 
    130                 135                 140                 


Asp His Leu Met Ala Lys Tyr Glu His Arg Ile Asp Glu Met Leu Ser 
145                 150                 155                 160 


Pro Gly Arg Arg Leu Leu Asn Ser His Trp Phe Trp Leu Lys Trp Val 
                165                 170                 175     


Ile Trp Ser Ser Leu Val Leu Ala Val Ile Phe Trp Leu Ala Phe Asp 
            180                 185                 190         


Thr Ala Lys Leu Gly Gln Gln Gln Leu Val Ser Phe Gly Gly Leu Ile 
        195                 200                 205             


Met Tyr Ile Val Leu Leu Phe Leu Phe Ser Lys Tyr Pro Thr Arg Val 
    210                 215                 220                 


Tyr Trp Arg Pro Val Leu Trp Gly Ile Gly Leu Gln Phe Leu Leu Gly 
225                 230                 235                 240 


Leu Leu Ile Leu Arg Thr Asp Pro Gly Phe Ile Ala Phe Asp Trp Leu 
                245                 250                 255     


Gly Arg Gln Val Gln Thr Phe Leu Glu Tyr Thr Asp Ala Gly Ala Ser 
            260                 265                 270         


Phe Val Phe Gly Glu Lys Tyr Lys Asp His Phe Phe Ala Phe Lys Val 
        275                 280                 285             


Leu Pro Ile Val Val Phe Phe Ser Thr Val Met Ser Met Leu Tyr Tyr 
    290                 295                 300                 


Leu Gly Leu Met Gln Trp Ile Ile Arg Lys Val Gly Trp Ile Met Leu 
305                 310                 315                 320 


Val Thr Thr Gly Ser Ser Pro Ile Glu Ser Val Val Ala Ser Gly Asn 
                325                 330                 335     


Ile Phe Val Gly Gln Thr Glu Ser Pro Leu Leu Val Arg Pro Tyr Leu 
            340                 345                 350         


Pro Tyr Ile Thr Lys Ser Glu Leu His Ala Ile Met Thr Ala Gly Phe 
        355                 360                 365             


Ser Thr Ile Ala Gly Ser Val Leu Gly Ala Tyr Ile Ser Phe Gly Val 
    370                 375                 380                 


Pro Ser Ser His Leu Leu Thr Ala Ser Val Met Ser Ala Pro Ala Ser 
385                 390                 395                 400 


Leu Ala Ala Ala Lys Leu Phe Trp Pro Glu Thr Glu Lys Pro Lys Ile 
                405                 410                 415     


Thr Leu Lys Asn Ala Met Lys Met Glu Ser Gly Asp Ser Gly Asn Leu 
            420                 425                 430         


Leu Glu Ala Ala Thr Gln Gly Ala Ser Ser Ser Ile Ser Leu Val Ala 
        435                 440                 445             


Asn Ile Ala Val Asn Leu Ile Ala Phe Leu Ala Leu Leu Ser Phe Met 
    450                 455                 460                 


Asn Ser Ala Leu Ser Trp Phe Gly Asn Met Phe Asp Tyr Pro Gln Leu 
465                 470                 475                 480 


Ser Phe Glu Leu Ile Cys Ser Tyr Ile Phe Met Pro Phe Ser Phe Met 
                485                 490                 495     


Met Gly Val Glu Trp Gln Asp Ser Phe Met Val Ala Arg Leu Ile Gly 
            500                 505                 510         


Tyr Lys Thr Phe Phe Asn Glu Phe Val Ala Tyr Glu His Leu Ser Lys 
        515                 520                 525             


Trp Ile His Leu Arg Lys Glu Gly Gly Pro Lys Phe Val Asn Gly Val 
    530                 535                 540                 


Gln Gln Tyr Ile Ser Ile Arg Ser Glu Ile Ile Ala Thr Tyr Ala Leu 
545                 550                 555                 560 


Cys Gly Phe Ala Asn Ile Gly Ser Leu Gly Ile Val Ile Gly Gly Leu 
                565                 570                 575     


Thr Ser Met Ala Pro Ser Arg Lys Arg Asp Ile Ala Ser Gly Ala Val 
            580                 585                 590         


Arg Ala Leu Ile Ala Gly Thr Val Ala Cys Phe Met Thr Ala Cys Ile 
        595                 600                 605             


Ala Gly Ile Leu Ser Ser Thr Pro Val Asp Ile Asn Cys His His Val 
    610                 615                 620                 


Leu Glu Asn Ala Phe Asn Ser Thr Phe Pro Gly Asn Thr Thr Lys Val 
625                 630                 635                 640 


Ile Ala Cys Cys Gln Ser Leu Leu Ser Ser Thr Val Ala Lys Gly Pro 
                645                 650                 655     


Gly Glu Val Ile Pro Gly Gly Asn His Ser Leu Tyr Ser Leu Lys Gly 
            660                 665                 670         


Cys Cys Thr Leu Leu Asn Pro Ser Thr Phe Asn Cys Asn Gly Ile Ser 
        675                 680                 685             


Asn Thr Phe 
    690     


<210>  4879
<211>  955
<212>  PRT
<213>  Homo sapiens

<400>  4879

Met Leu Pro Gly Arg Leu Cys Trp Val Pro Leu Leu Leu Ala Leu Gly 
1               5                   10                  15      


Val Gly Ser Gly Ser Gly Gly Gly Gly Asp Ser Arg Gln Arg Arg Leu 
            20                  25                  30          


Leu Ala Ala Lys Val Asn Lys His Lys Pro Trp Ile Glu Thr Ser Tyr 
        35                  40                  45              


His Gly Val Ile Thr Glu Asn Asn Asp Thr Val Ile Leu Asp Pro Pro 
    50                  55                  60                  


Leu Val Ala Leu Asp Lys Asp Ala Pro Val Pro Phe Ala Gly Glu Ile 
65                  70                  75                  80  


Cys Ala Phe Lys Ile His Gly Gln Glu Leu Pro Phe Glu Ala Val Val 
                85                  90                  95      


Leu Asn Lys Thr Ser Gly Glu Gly Arg Leu Arg Ala Lys Ser Pro Ile 
            100                 105                 110         


Asp Cys Glu Leu Gln Lys Glu Tyr Thr Phe Ile Ile Gln Ala Tyr Asp 
        115                 120                 125             


Cys Gly Ala Gly Pro His Glu Thr Ala Trp Lys Lys Ser His Lys Ala 
    130                 135                 140                 


Val Val His Ile Gln Val Lys Asp Val Asn Glu Phe Ala Pro Thr Phe 
145                 150                 155                 160 


Lys Glu Pro Ala Tyr Lys Ala Val Val Thr Glu Gly Lys Ile Tyr Asp 
                165                 170                 175     


Ser Ile Leu Gln Val Glu Ala Ile Asp Glu Asp Cys Ser Pro Gln Tyr 
            180                 185                 190         


Ser Gln Ile Cys Asn Tyr Glu Ile Val Thr Thr Asp Val Pro Phe Ala 
        195                 200                 205             


Ile Asp Arg Asn Gly Asn Ile Arg Asn Thr Glu Lys Leu Ser Tyr Asp 
    210                 215                 220                 


Lys Gln His Gln Tyr Glu Ile Leu Val Thr Ala Tyr Asp Cys Gly Gln 
225                 230                 235                 240 


Lys Pro Ala Ala Gln Asp Thr Leu Val Gln Val Asp Val Lys Pro Val 
                245                 250                 255     


Cys Lys Pro Gly Trp Gln Asp Trp Thr Lys Arg Ile Glu Tyr Gln Pro 
            260                 265                 270         


Gly Ser Gly Ser Met Pro Leu Phe Pro Ser Ile His Leu Glu Thr Cys 
        275                 280                 285             


Asp Gly Ala Val Ser Ser Leu Gln Ile Val Thr Glu Leu Gln Thr Asn 
    290                 295                 300                 


Tyr Ile Gly Lys Gly Cys Asp Arg Glu Thr Tyr Ser Glu Lys Ser Leu 
305                 310                 315                 320 


Gln Lys Leu Cys Gly Ala Ser Ser Gly Ile Ile Asp Leu Leu Pro Ser 
                325                 330                 335     


Pro Ser Ala Ala Thr Asn Trp Thr Ala Gly Leu Leu Val Asp Ser Ser 
            340                 345                 350         


Glu Met Ile Phe Lys Phe Asp Gly Arg Gln Gly Ala Lys Val Pro Asp 
        355                 360                 365             


Gly Ile Val Pro Lys Asn Leu Thr Asp Gln Phe Thr Ile Thr Met Trp 
    370                 375                 380                 


Met Lys His Gly Pro Ser Pro Gly Val Arg Ala Glu Lys Glu Thr Ile 
385                 390                 395                 400 


Leu Cys Asn Ser Asp Lys Thr Glu Met Asn Arg His His Tyr Ala Leu 
                405                 410                 415     


Tyr Val His Asn Cys Arg Leu Val Phe Leu Leu Arg Lys Asp Phe Asp 
            420                 425                 430         


Gln Ala Asp Thr Phe Arg Pro Ala Glu Phe His Trp Lys Leu Asp Gln 
        435                 440                 445             


Ile Cys Asp Lys Glu Trp His Tyr Tyr Val Ile Asn Val Glu Phe Pro 
    450                 455                 460                 


Val Val Thr Leu Tyr Met Asp Gly Ala Thr Tyr Glu Pro Tyr Leu Val 
465                 470                 475                 480 


Thr Asn Asp Trp Pro Ile His Pro Ser His Ile Ala Met Gln Leu Thr 
                485                 490                 495     


Val Gly Ala Cys Trp Gln Gly Gly Glu Val Thr Lys Pro Gln Phe Ala 
            500                 505                 510         


Gln Phe Phe His Gly Ser Leu Ala Ser Leu Thr Ile Arg Pro Gly Lys 
        515                 520                 525             


Met Glu Ser Gln Lys Val Ile Ser Cys Leu Gln Ala Cys Lys Glu Gly 
    530                 535                 540                 


Leu Asp Ile Asn Ser Leu Glu Ser Leu Gly Gln Gly Ile Lys Tyr His 
545                 550                 555                 560 


Phe Asn Pro Ser Gln Ser Ile Leu Val Met Glu Gly Asp Asp Ile Gly 
                565                 570                 575     


Asn Ile Asn Arg Ala Leu Gln Lys Val Ser Tyr Ile Asn Ser Arg Gln 
            580                 585                 590         


Phe Pro Thr Ala Gly Val Arg Arg Leu Lys Val Ser Ser Lys Val Gln 
        595                 600                 605             


Cys Phe Gly Glu Asp Val Cys Ile Ser Ile Pro Glu Val Asp Ala Tyr 
    610                 615                 620                 


Val Met Val Leu Gln Ala Ile Glu Pro Arg Ile Thr Leu Arg Gly Thr 
625                 630                 635                 640 


Asp His Phe Trp Arg Pro Ala Ala Gln Phe Glu Ser Ala Arg Gly Val 
                645                 650                 655     


Thr Leu Phe Pro Asp Ile Lys Ile Val Ser Thr Phe Ala Lys Thr Glu 
            660                 665                 670         


Ala Pro Gly Asp Val Lys Thr Thr Asp Pro Lys Ser Glu Val Leu Glu 
        675                 680                 685             


Glu Met Leu His Asn Leu Asp Phe Cys Asp Ile Leu Val Ile Gly Gly 
    690                 695                 700                 


Asp Leu Asp Pro Arg Gln Glu Cys Leu Glu Leu Asn His Ser Glu Leu 
705                 710                 715                 720 


His Gln Arg His Leu Asp Ala Thr Asn Ser Thr Ala Gly Tyr Ser Ile 
                725                 730                 735     


Tyr Gly Val Gly Ser Met Ser Arg Tyr Glu Gln Val Leu His His Ile 
            740                 745                 750         


Arg Tyr Arg Asn Trp Arg Pro Ala Ser Leu Glu Ala Arg Arg Phe Arg 
        755                 760                 765             


Ile Lys Cys Ser Glu Leu Asn Gly Arg Tyr Thr Ser Asn Glu Phe Asn 
    770                 775                 780                 


Leu Glu Val Ser Ile Leu His Glu Asp Gln Val Ser Asp Lys Glu His 
785                 790                 795                 800 


Val Asn His Leu Ile Val Gln Pro Pro Phe Leu Gln Ser Val His His 
                805                 810                 815     


Pro Glu Ser Arg Ser Ser Ile Gln His Ser Ser Val Val Pro Ser Ile 
            820                 825                 830         


Ala Thr Val Val Ile Ile Ile Ser Val Cys Met Leu Val Phe Val Val 
        835                 840                 845             


Ala Met Gly Val Tyr Arg Val Arg Ile Ala His Gln His Phe Ile Gln 
    850                 855                 860                 


Glu Thr Glu Ala Ala Lys Glu Ser Glu Met Asp Trp Asp Asp Ser Ala 
865                 870                 875                 880 


Leu Thr Ile Thr Val Asn Pro Met Glu Lys His Glu Gly Pro Gly His 
                885                 890                 895     


Gly Glu Asp Glu Thr Glu Gly Glu Glu Glu Glu Glu Ala Glu Glu Glu 
            900                 905                 910         


Met Ser Ser Ser Ser Gly Ser Asp Asp Ser Glu Glu Glu Glu Glu Glu 
        915                 920                 925             


Glu Gly Met Gly Arg Gly Arg His Gly Gln Asn Gly Ala Arg Gln Ala 
    930                 935                 940                 


Gln Leu Glu Trp Asp Asp Ser Thr Leu Pro Tyr 
945                 950                 955 


<210>  4880
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  4880

Met Met Ser Met Leu Gly Gly Leu Gln Arg Tyr Phe Arg Val Ile Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ala Leu Thr Leu Leu Leu Leu Ala Gly Phe Leu His 
            20                  25                  30          


Ser Asp Leu Glu Leu Asp Thr Pro Leu Phe Gly Gly Gln Ala Glu Gly 
        35                  40                  45              


Pro Pro Val Thr Asn Ile Met Phe Leu Lys Thr His Lys Thr Ala Ser 
    50                  55                  60                  


Ser Thr Val Leu Asn Ile Leu Tyr Arg Phe Ala Glu Thr His Asn Leu 
65                  70                  75                  80  


Ser Val Ala Leu Pro Ala Gly Ser Arg Val His Leu Gly Tyr Pro Trp 
                85                  90                  95      


Leu Phe Leu Ala Arg Tyr Val Glu Gly Val Gly Ser Gln Gln Arg Phe 
            100                 105                 110         


Asn Ile Met Cys Asn His Leu Arg Phe Asn Leu Pro Gln Val Gln Lys 
        115                 120                 125             


Val Met Pro Asn Asp Thr Phe Tyr Phe Ser Ile Leu Arg Asn Pro Val 
    130                 135                 140                 


Phe Gln Leu Glu Ser Ser Phe Ile Tyr Tyr Lys Thr Tyr Ala Pro Ala 
145                 150                 155                 160 


Phe Arg Gly Ala Pro Ser Leu Asp Ala Phe Leu Ala Ser Pro Arg Thr 
                165                 170                 175     


Phe Tyr Asn Asp Ser Arg His Leu Arg Asn Val Tyr Ala Lys Asn Asn 
            180                 185                 190         


Met Trp Phe Asp Phe Gly Phe Asp Pro Asn Ala Gln Cys Glu Glu Gly 
        195                 200                 205             


Tyr Val Arg Ala Arg Ile Ala Glu Val Glu Arg Arg Phe Arg Leu Val 
    210                 215                 220                 


Leu Ile Ala Glu His Leu Asp Glu Ser Leu Val Leu Leu Arg Arg Arg 
225                 230                 235                 240 


Leu Arg Trp Ala Leu Asp Asp Val Val Ala Phe Arg Leu Asn Ser Arg 
                245                 250                 255     


Ser Ala Arg Ser Val Ala Arg Leu Ser Pro Glu Thr Arg Glu Arg Ala 
            260                 265                 270         


Arg Ser Trp Cys Ala Leu Asp Trp Arg Leu Tyr Glu His Phe Asn Arg 
        275                 280                 285             


Thr Leu Trp Ala Gln Leu Arg Ala Glu Leu Gly Pro Arg Arg Leu Arg 
    290                 295                 300                 


Gly Glu Val Glu Arg Leu Arg Ala Arg Arg Arg Glu Leu Ala Ser Leu 
305                 310                 315                 320 


Cys Leu Gln Asp Gly Gly Ala Leu Lys Asn His Thr Gln Ile Arg Asp 
                325                 330                 335     


Pro Arg Leu Arg Pro Tyr Gln Ser Gly Lys Ala Asp Ile Leu Gly Tyr 
            340                 345                 350         


Asn Leu Arg Pro Gly Leu Asp Asn Gln Thr Leu Gly Val Cys Gln Arg 
        355                 360                 365             


Leu Val Met Pro Glu Leu Gln Tyr Met Ala Arg Leu Tyr Ala Leu Gln 
    370                 375                 380                 


Phe Pro Glu Lys Pro Leu Lys Asn Ile Pro Phe Leu Gly Ala 
385                 390                 395             


<210>  4881
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  4881

Met Ser Ala Asn Ser Ser Arg Val Gly Gln Leu Leu Leu Gln Gly Ser 
1               5                   10                  15      


Ala Cys Ile Arg Trp Lys Gln Asp Val Glu Gly Ala Val Tyr His Leu 
            20                  25                  30          


Ala Asn Cys Leu Leu Leu Leu Gly Phe Met Gly Gly Ser Gly Val Tyr 
        35                  40                  45              


Gly Cys Phe Tyr Leu Phe Gly Phe Leu Ser Ala Gly Tyr Leu Cys Cys 
    50                  55                  60                  


Val Leu Trp Gly Trp Phe Ser Ala Cys Gly Leu Asp Ile Val Leu Trp 
65                  70                  75                  80  


Ser Phe Leu Leu Ala Val Val Cys Leu Leu Gln Leu Ala His Leu Val 
                85                  90                  95      


Tyr Arg Leu Arg Glu Asp Thr Leu Pro Glu Glu Phe Asp Leu Leu Tyr 
            100                 105                 110         


Lys Thr Leu Cys Leu Pro Leu Gln Val Pro Leu Gln Thr Tyr Lys Glu 
        115                 120                 125             


Ile Val His Cys Cys Glu Glu Gln Val Leu Thr Leu Ala Thr Glu Gln 
    130                 135                 140                 


Thr Tyr Ala Val Glu Gly Glu Thr Pro Ile Asn Arg Leu Ser Leu Leu 
145                 150                 155                 160 


Leu Ser Gly Arg Val Arg Val Ser Gln Asp Gly Gln Phe Leu His Tyr 
                165                 170                 175     


Ile Phe Pro Tyr Gln Phe Met Asp Ser Pro Glu Trp Glu Ser Leu Gln 
            180                 185                 190         


Pro Ser Glu Glu Gly Val Phe Gln Val Thr Leu Thr Ala Glu Thr Ser 
        195                 200                 205             


Cys Ser Tyr Ile Ser Trp Pro Arg Lys Ser Leu His Leu Leu Leu Thr 
    210                 215                 220                 


Lys Glu Arg Tyr Ile Ser Cys Leu Phe Ser Ala Leu Leu Gly Tyr Asp 
225                 230                 235                 240 


Ile Ser Glu Lys Leu Tyr Thr Leu Asn Asp Lys Leu Phe Ala Lys Phe 
                245                 250                 255     


Gly Leu Arg Phe Asp Ile Arg Leu Pro Ser Leu Tyr His Val Leu Gly 
            260                 265                 270         


Pro Thr Ala Ala Asp Ala Gly Pro Glu Ser Glu Lys Gly Asp Glu Glu 
        275                 280                 285             


Val Cys Glu Pro Ala Val Ser Pro Pro Gln Ala Thr Pro Thr Ser Leu 
    290                 295                 300                 


Gln Gln Thr Pro Pro Cys Ser Thr Pro Pro Ala Thr Thr Asn Phe Pro 
305                 310                 315                 320 


Ala Pro Pro Thr Arg Ala Arg Leu Ser Arg Pro Asp Ser Gly Ile Leu 
                325                 330                 335     


Ala Ser Arg Ile Pro Leu Gln Ser Tyr Ser Gln Val Ile Ser Arg Gly 
            340                 345                 350         


Gln Ala Pro Leu Ala Pro Thr His Thr Pro Glu Leu 
        355                 360                 


<210>  4882
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  4882

Met Leu Leu Pro Gln Leu Cys Trp Leu Pro Leu Leu Ala Gly Leu Leu 
1               5                   10                  15      


Pro Pro Val Pro Ala Gln Lys Phe Ser Ala Leu Thr Phe Leu Arg Val 
            20                  25                  30          


Asp Gln Asp Lys Asp Lys Asp Cys Ser Leu Asp Cys Ala Gly Ser Pro 
        35                  40                  45              


Gln Lys Pro Leu Cys Ala Ser Asp Gly Arg Thr Phe Leu Ser Arg Cys 
    50                  55                  60                  


Glu Phe Gln Arg Ala Lys Cys Lys Asp Pro Gln Leu Glu Ile Ala Tyr 
65                  70                  75                  80  


Arg Gly Asn Cys Lys Asp Val Ser Arg Cys Val Ala Glu Arg Lys Tyr 
                85                  90                  95      


Thr Gln Glu Gln Ala Arg Lys Glu Phe Gln Gln Val Phe Ile Pro Glu 
            100                 105                 110         


Cys Asn Asp Asp Gly Thr Tyr Ser Gln Val Gln Cys His Ser Tyr Thr 
        115                 120                 125             


Gly Tyr Cys Trp Cys Val Thr Pro Asn Gly Arg Pro Ile Ser Gly Thr 
    130                 135                 140                 


Ala Val Ala His Lys Thr Pro Arg Cys Pro Gly Ser Val Asn Glu Lys 
145                 150                 155                 160 


Leu Pro Gln Arg Glu Gly Thr Gly Lys Thr Val Ser Leu Gln Ile Phe 
                165                 170                 175     


Ser Val Leu Asn Ser Asp Asp Ala Ala Ala Pro Ala Leu Glu Thr Gln 
            180                 185                 190         


Pro Gln Gly Asp Glu Glu Asp Ile Ala Ser Arg Tyr Pro Thr Leu Trp 
        195                 200                 205             


Thr Glu Gln Val Lys Ser Arg Gln Asn Lys Thr Asn Lys Asn Ser Val 
    210                 215                 220                 


Ser Ser Cys Asp Gln Glu His Gln Ser Ala Leu Glu Glu Ala Lys Gln 
225                 230                 235                 240 


Pro Lys Asn Asp Asn Val Val Ile Pro Glu Cys Ala His Gly Gly Leu 
                245                 250                 255     


Tyr Lys Pro Val Gln Cys His Pro Ser Thr Gly Tyr Cys Trp Cys Val 
            260                 265                 270         


Leu Val Asp Thr Gly Arg Pro Ile Pro Gly Thr Ser Thr Arg Tyr Glu 
        275                 280                 285             


Gln Pro Lys Cys Asp Asn Thr Ala Arg Ala His Pro Ala Lys Ala Arg 
    290                 295                 300                 


Asp Leu Tyr Lys Gly Arg Gln Leu Gln Gly Cys Pro Gly Ala Lys Lys 
305                 310                 315                 320 


His Glu Phe Leu Thr Ser Val Leu Asp Ala Leu Ser Thr Asp Met Val 
                325                 330                 335     


His Ala Ala Ser Asp Pro Ser Ser Ser Ser Gly Arg Leu Ser Glu Pro 
            340                 345                 350         


Asp Pro Ser His Thr Leu Glu Glu Arg Val Val His Trp Tyr Phe Lys 
        355                 360                 365             


Leu Leu Asp Lys Asn Ser Ser Gly Asp Ile Gly Lys Lys Glu Ile Lys 
    370                 375                 380                 


Pro Phe Lys Arg Phe Leu Arg Lys Lys Ser Lys Pro Lys Lys Cys Val 
385                 390                 395                 400 


Lys Lys Phe Val Glu Tyr Cys Asp Val Asn Asn Asp Lys Ser Ile Ser 
                405                 410                 415     


Val Gln Glu Leu Met Gly Cys Leu Gly Val Ala Lys Glu Asp Gly Lys 
            420                 425                 430         


Ala Asp Thr Lys Lys Arg His Thr Pro Arg Gly His Ala Glu Ser Thr 
        435                 440                 445             


Ser Asn Arg Gln Pro Arg Lys Gln Gly 
    450                 455         


<210>  4883
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  4883

Met Thr Arg Trp Ser Ser Tyr Leu Leu Gly Trp Thr Thr Phe Leu Leu 
1               5                   10                  15      


Tyr Ser Tyr Glu Ser Ser Gly Gly Met His Glu Glu Cys Val Phe Pro 
            20                  25                  30          


Phe Thr Tyr Lys Gly Ser Val Tyr Phe Thr Cys Thr His Ile His Ser 
        35                  40                  45              


Leu Ser Pro Trp Cys Ala Thr Arg Ala Val Tyr Asn Gly Gln Trp Lys 
    50                  55                  60                  


Tyr Cys Gln Ser Glu Asp Tyr Pro Arg Cys Ile Phe Pro Phe Ile Tyr 
65                  70                  75                  80  


Arg Gly Lys Ala Tyr Asn Ser Cys Ile Ser Gln Gly Ser Phe Leu Gly 
                85                  90                  95      


Ser Leu Trp Cys Ser Val Thr Ser Val Phe Asp Glu Lys Gln Gln Trp 
            100                 105                 110         


Lys Phe Cys Glu Thr Asn Glu Tyr Gly Gly Asn Ser Leu Arg Lys Pro 
        115                 120                 125             


Cys Ile Phe Pro Ser Ile Tyr Arg Asn Asn Val Val Ser Asp Cys Met 
    130                 135                 140                 


Glu Asp Glu Ser Asn Lys Leu Trp Cys Pro Thr Thr Glu Asn Met Asp 
145                 150                 155                 160 


Lys Asp Gly Lys Trp Ser Phe Cys Ala Asp Thr Arg Ile Ser Ala Leu 
                165                 170                 175     


Val Pro Gly Phe Pro Cys His Phe Pro Phe Asn Tyr Lys Asn Lys Asn 
            180                 185                 190         


Tyr Phe Asn Cys Thr Asn Glu Gly Ser Lys Glu Asn Leu Val Trp Cys 
        195                 200                 205             


Ala Thr Ser Tyr Asn Tyr Asp Gln Asp His Thr Trp Val Tyr Cys 
    210                 215                 220             


<210>  4884
<211>  653
<212>  PRT
<213>  Homo sapiens

<400>  4884

Met Lys Leu Leu Trp Gln Val Thr Val His His His Thr Trp Asn Ala 
1               5                   10                  15      


Ile Leu Leu Pro Phe Val Tyr Leu Thr Ala Gln Val Trp Ile Leu Cys 
            20                  25                  30          


Ala Ala Ile Ala Ala Ala Ala Ser Ala Gly Pro Gln Asn Cys Pro Ser 
        35                  40                  45              


Val Cys Ser Cys Ser Asn Gln Phe Ser Lys Val Val Cys Thr Arg Arg 
    50                  55                  60                  


Gly Leu Ser Glu Val Pro Gln Gly Ile Pro Ser Asn Thr Arg Tyr Leu 
65                  70                  75                  80  


Asn Leu Met Glu Asn Asn Ile Gln Met Ile Gln Ala Asp Thr Phe Arg 
                85                  90                  95      


His Leu His His Leu Glu Val Leu Gln Leu Gly Arg Asn Ser Ile Arg 
            100                 105                 110         


Gln Ile Glu Val Gly Ala Phe Asn Gly Leu Ala Ser Leu Asn Thr Leu 
        115                 120                 125             


Glu Leu Phe Asp Asn Trp Leu Thr Val Ile Pro Ser Gly Ala Phe Glu 
    130                 135                 140                 


Tyr Leu Ser Lys Leu Arg Glu Leu Trp Leu Arg Asn Asn Pro Ile Glu 
145                 150                 155                 160 


Ser Ile Pro Ser Tyr Ala Phe Asn Arg Val Pro Ser Leu Met Arg Leu 
                165                 170                 175     


Asp Leu Gly Glu Leu Lys Lys Leu Glu Tyr Ile Ser Glu Gly Ala Phe 
            180                 185                 190         


Glu Gly Leu Phe Asn Leu Lys Tyr Leu Asn Leu Gly Met Cys Asn Ile 
        195                 200                 205             


Lys Asp Met Pro Asn Leu Thr Pro Leu Val Gly Leu Glu Glu Leu Glu 
    210                 215                 220                 


Met Ser Gly Asn His Phe Pro Glu Ile Arg Pro Gly Ser Phe His Gly 
225                 230                 235                 240 


Leu Ser Ser Leu Lys Lys Leu Trp Val Met Asn Ser Gln Val Ser Leu 
                245                 250                 255     


Ile Glu Arg Asn Ala Phe Asp Gly Leu Ala Ser Leu Val Glu Leu Asn 
            260                 265                 270         


Leu Ala His Asn Asn Leu Ser Ser Leu Pro His Asp Leu Phe Thr Pro 
        275                 280                 285             


Leu Arg Tyr Leu Val Glu Leu His Leu His His Asn Pro Trp Asn Cys 
    290                 295                 300                 


Asp Cys Asp Ile Leu Trp Leu Ala Trp Trp Leu Arg Glu Tyr Ile Pro 
305                 310                 315                 320 


Thr Asn Ser Thr Cys Cys Gly Arg Cys His Ala Pro Met His Met Arg 
                325                 330                 335     


Gly Arg Tyr Leu Val Glu Val Asp Gln Ala Ser Phe Gln Cys Ser Ala 
            340                 345                 350         


Pro Phe Ile Met Asp Ala Pro Arg Asp Leu Asn Ile Ser Glu Gly Arg 
        355                 360                 365             


Met Ala Glu Leu Lys Cys Arg Thr Pro Pro Met Ser Ser Val Lys Trp 
    370                 375                 380                 


Leu Leu Pro Asn Gly Thr Val Leu Ser His Ala Ser Arg His Pro Arg 
385                 390                 395                 400 


Ile Ser Val Leu Asn Asp Gly Thr Leu Asn Phe Ser His Val Leu Leu 
                405                 410                 415     


Ser Asp Thr Gly Val Tyr Thr Cys Met Val Thr Asn Val Ala Gly Asn 
            420                 425                 430         


Ser Asn Ala Ser Ala Tyr Leu Asn Val Ser Thr Ala Glu Leu Asn Thr 
        435                 440                 445             


Ser Asn Tyr Ser Phe Phe Thr Thr Val Thr Val Glu Thr Thr Glu Ile 
    450                 455                 460                 


Ser Pro Glu Asp Thr Thr Arg Lys Tyr Lys Pro Val Pro Thr Thr Ser 
465                 470                 475                 480 


Thr Gly Tyr Gln Pro Ala Tyr Thr Thr Ser Thr Thr Val Leu Ile Gln 
                485                 490                 495     


Thr Thr Arg Val Pro Lys Gln Val Ala Val Pro Ala Thr Asp Thr Thr 
            500                 505                 510         


Asp Lys Met Gln Thr Ser Leu Asp Glu Val Met Lys Thr Thr Lys Ile 
        515                 520                 525             


Ile Ile Gly Cys Phe Val Ala Val Thr Leu Leu Ala Ala Ala Met Leu 
    530                 535                 540                 


Ile Val Phe Tyr Lys Leu Arg Lys Arg His Gln Gln Arg Ser Thr Val 
545                 550                 555                 560 


Thr Ala Ala Arg Thr Val Glu Ile Ile Gln Val Asp Glu Asp Ile Pro 
                565                 570                 575     


Ala Ala Thr Ser Ala Ala Ala Thr Ala Ala Pro Ser Gly Val Ser Gly 
            580                 585                 590         


Glu Gly Ala Val Val Leu Pro Thr Ile His Asp His Ile Asn Tyr Asn 
        595                 600                 605             


Thr Tyr Lys Pro Ala His Gly Ala His Trp Thr Glu Asn Ser Leu Gly 
    610                 615                 620                 


Asn Ser Leu His Pro Thr Val Thr Thr Ile Ser Glu Pro Tyr Ile Ile 
625                 630                 635                 640 


Gln Thr His Thr Lys Asp Lys Val Gln Glu Thr Gln Ile 
                645                 650             


<210>  4885
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  4885

Met Ala Lys Asn Pro Pro Glu Asn Cys Glu Asp Cys His Ile Leu Asn 
1               5                   10                  15      


Ala Glu Ala Phe Lys Ser Lys Lys Ile Cys Lys Ser Leu Lys Ile Cys 
            20                  25                  30          


Gly Leu Val Phe Gly Ile Leu Ala Leu Thr Leu Ile Val Leu Phe Trp 
        35                  40                  45              


Gly Ser Lys His Phe Trp Pro Glu Val Pro Lys Lys Ala Tyr Asp Met 
    50                  55                  60                  


Glu His Thr Phe Tyr Ser Asn Gly Glu Lys Lys Lys Ile Tyr Met Glu 
65                  70                  75                  80  


Ile Asp Pro Val Thr Arg Thr Glu Ile Phe Arg Ser Gly Asn Gly Thr 
                85                  90                  95      


Asp Glu Thr Leu Glu Val His Asp Phe Lys Asn Gly Tyr Thr Gly Ile 
            100                 105                 110         


Tyr Phe Val Gly Leu Gln Lys Cys Phe Ile Lys Thr Gln Ile Lys Val 
        115                 120                 125             


Ile Pro Glu Phe Ser Glu Pro Glu Glu Glu Ile Asp Glu Asn Glu Glu 
    130                 135                 140                 


Ile Thr Thr Thr Phe Phe Glu Gln Ser Val Ile Trp Val Pro Ala Glu 
145                 150                 155                 160 


Lys Pro Ile Glu Asn Arg Asp Phe Leu Lys Asn Ser Lys Ile Leu Glu 
                165                 170                 175     


Ile Cys Asp Asn Val Thr Met Tyr Trp Ile Asn Pro Thr Leu Ile Ser 
            180                 185                 190         


Val Ser Glu Leu Gln Asp Phe Glu Glu Glu Gly Glu Asp Leu His Phe 
        195                 200                 205             


Pro Ala Asn Glu Lys Lys Gly Ile Glu Gln Asn Glu Gln Trp Val Val 
    210                 215                 220                 


Pro Gln Val Lys Val Glu Lys Thr Arg His Ala Arg Gln Ala Ser Glu 
225                 230                 235                 240 


Glu Glu Leu Pro Ile Asn Asp Tyr Thr Glu Asn Gly Ile Glu Phe Asp 
                245                 250                 255     


Pro Met Leu Asp Glu Arg Gly Tyr Cys Cys Ile Tyr Cys Arg Arg Gly 
            260                 265                 270         


Asn Arg Tyr Cys Arg Arg Val Cys Glu Pro Leu Leu Gly Tyr Tyr Pro 
        275                 280                 285             


Tyr Pro Tyr Cys Tyr Gln Gly Gly Arg Val Ile Cys Arg Val Ile Met 
    290                 295                 300                 


Pro Cys Asn Trp Trp Val Ala Arg Met Leu Gly Arg Val 
305                 310                 315         


<210>  4886
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  4886

Met Glu Gly Glu Pro Ser Gln Pro Pro Asn Ser Ser Trp Pro Leu Ser 
1               5                   10                  15      


Gln Asn Gly Thr Asn Thr Glu Ala Thr Pro Ala Thr Asn Leu Thr Phe 
            20                  25                  30          


Ser Ser Tyr Tyr Gln His Thr Ser Pro Val Ala Ala Met Phe Ile Val 
        35                  40                  45              


Ala Tyr Ala Leu Ile Phe Leu Leu Cys Met Val Gly Asn Thr Leu Val 
    50                  55                  60                  


Cys Phe Ile Val Leu Lys Asn Arg His Met His Thr Val Thr Asn Met 
65                  70                  75                  80  


Phe Ile Leu Asn Leu Ala Val Ser Asp Leu Leu Val Gly Ile Phe Cys 
                85                  90                  95      


Met Pro Thr Thr Leu Val Asp Asn Leu Ile Thr Gly Trp Pro Phe Asp 
            100                 105                 110         


Asn Ala Thr Cys Lys Met Ser Gly Leu Val Gln Gly Met Ser Val Ser 
        115                 120                 125             


Ala Ser Val Phe Thr Leu Val Ala Ile Ala Val Glu Arg Phe Arg Cys 
    130                 135                 140                 


Ile Val His Pro Phe Arg Glu Lys Leu Thr Leu Arg Lys Ala Leu Val 
145                 150                 155                 160 


Thr Ile Ala Val Ile Trp Ala Leu Ala Leu Leu Ile Met Cys Pro Ser 
                165                 170                 175     


Ala Val Thr Leu Thr Val Thr Arg Glu Glu His His Phe Met Val Asp 
            180                 185                 190         


Ala Arg Asn Arg Ser Tyr Pro Leu Tyr Ser Cys Trp Glu Ala Trp Pro 
        195                 200                 205             


Glu Lys Gly Met Arg Arg Val Tyr Thr Thr Val Leu Phe Ser His Ile 
    210                 215                 220                 


Tyr Leu Ala Pro Leu Ala Leu Ile Val Val Met Tyr Ala Arg Ile Ala 
225                 230                 235                 240 


Arg Lys Leu Cys Gln Ala Pro Gly Pro Ala Pro Gly Gly Glu Glu Ala 
                245                 250                 255     


Ala Asp Pro Arg Ala Ser Arg Arg Arg Ala Arg Val Val His Met Leu 
            260                 265                 270         


Val Met Val Ala Leu Phe Phe Thr Leu Ser Trp Leu Pro Leu Trp Ala 
        275                 280                 285             


Leu Leu Leu Leu Ile Asp Tyr Gly Gln Leu Ser Ala Pro Gln Leu His 
    290                 295                 300                 


Leu Val Thr Val Tyr Ala Phe Pro Phe Ala His Trp Leu Ala Phe Phe 
305                 310                 315                 320 


Asn Ser Ser Ala Asn Pro Ile Ile Tyr Gly Tyr Phe Asn Glu Asn Phe 
                325                 330                 335     


Arg Arg Gly Phe Gln Ala Ala Phe Arg Ala Arg Leu Cys Pro Arg Pro 
            340                 345                 350         


Ser Gly Ser His Lys Glu Ala Tyr Ser Glu Arg Pro Gly Gly Leu Leu 
        355                 360                 365             


His Arg Arg Val Phe Val Val Val Arg Pro Ser Asp Ser Gly Leu Pro 
    370                 375                 380                 


Ser Glu Ser Gly Pro Ser Ser Gly Ala Pro Arg Pro Gly Arg Leu Pro 
385                 390                 395                 400 


Leu Arg Asn Gly Arg Val Ala His His Gly Leu Pro Arg Glu Gly Pro 
                405                 410                 415     


Gly Cys Ser His Leu Pro Leu Thr Ile Pro Ala Trp Asp Ile 
            420                 425                 430 


<210>  4887
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  4887

Met Ser Asn Pro Ser Ala Pro Pro Pro Tyr Glu Asp Arg Asn Pro Leu 
1               5                   10                  15      


Tyr Pro Gly Pro Pro Pro Pro Gly Gly Tyr Gly Gln Pro Ser Val Leu 
            20                  25                  30          


Pro Gly Gly Tyr Pro Ala Tyr Pro Gly Tyr Pro Gln Pro Gly Tyr Gly 
        35                  40                  45              


His Pro Ala Gly Tyr Pro Gln Pro Met Pro Pro Thr His Pro Met Pro 
    50                  55                  60                  


Met Asn Tyr Gly Pro Gly His Gly Tyr Asp Gly Glu Glu Arg Ala Val 
65                  70                  75                  80  


Ser Asp Ser Phe Gly Pro Gly Glu Trp Asp Asp Arg Lys Val Arg His 
                85                  90                  95      


Thr Phe Ile Arg Lys Val Tyr Ser Ile Ile Ser Val Gln Leu Leu Ile 
            100                 105                 110         


Thr Val Ala Ile Ile Ala Ile Phe Thr Phe Val Glu Pro Val Ser Ala 
        115                 120                 125             


Phe Val Arg Arg Asn Val Ala Val Tyr Tyr Val Ser Tyr Ala Val Phe 
    130                 135                 140                 


Val Val Thr Tyr Leu Ile Leu Ala Cys Cys Gln Gly Pro Arg Arg Arg 
145                 150                 155                 160 


Phe Pro Trp Asn Ile Ile Leu Leu Thr Leu Phe Thr Phe Ala Met Gly 
                165                 170                 175     


Phe Met Thr Gly Thr Ile Ser Ser Met Tyr Gln Thr Lys Ala Val Ile 
            180                 185                 190         


Ile Ala Met Ile Ile Thr Ala Val Val Ser Ile Ser Val Thr Ile Phe 
        195                 200                 205             


Cys Phe Gln Thr Lys Val Asp Phe Thr Ser Cys Thr Gly Leu Phe Cys 
    210                 215                 220                 


Val Leu Gly Ile Val Leu Leu Val Thr Gly Ile Val Thr Ser Ile Val 
225                 230                 235                 240 


Leu Tyr Phe Gln Tyr Val Tyr Trp Leu His Met Leu Tyr Ala Ala Leu 
                245                 250                 255     


Gly Ala Ile Cys Phe Thr Leu Phe Leu Ala Tyr Asp Thr Gln Leu Val 
            260                 265                 270         


Leu Gly Asn Arg Lys His Thr Ile Ser Pro Glu Asp Tyr Ile Thr Gly 
        275                 280                 285             


Ala Leu Gln Ile Tyr Thr Asp Ile Ile Tyr Ile Phe Thr Phe Val Leu 
    290                 295                 300                 


Gln Leu Met Gly Asp Arg Asn 
305                 310     


<210>  4888
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  4888

Met Gly Val Pro Thr Ala Leu Glu Ala Gly Ser Trp Arg Trp Gly Ser 
1               5                   10                  15      


Leu Leu Phe Ala Leu Phe Leu Ala Ala Ser Leu Gly Pro Val Ala Ala 
            20                  25                  30          


Phe Lys Val Ala Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
        35                  40                  45              


Asn Val Thr Leu Thr Cys Arg Leu Leu Gly Pro Val Asp Lys Gly His 
    50                  55                  60                  


Asp Val Thr Phe Tyr Lys Thr Trp Tyr Arg Ser Ser Arg Gly Glu Val 
65                  70                  75                  80  


Gln Thr Cys Ser Glu Arg Arg Pro Ile Arg Asn Leu Thr Phe Gln Asp 
                85                  90                  95      


Leu His Leu His His Gly Gly His Gln Ala Ala Asn Thr Ser His Asp 
            100                 105                 110         


Leu Ala Gln Arg His Gly Leu Glu Ser Ala Ser Asp His His Gly Asn 
        115                 120                 125             


Phe Ser Ile Thr Met Arg Asn Leu Thr Leu Leu Asp Ser Gly Leu Tyr 
    130                 135                 140                 


Cys Cys Leu Val Val Glu Ile Arg His His His Ser Glu His Arg Val 
145                 150                 155                 160 


His Gly Ala Met Glu Leu Gln Val Gln Thr Gly Lys Asp Ala Pro Ser 
                165                 170                 175     


Asn Cys Val Val Tyr Pro Ser Ser Ser Gln Asp Ser Glu Asn Ile Thr 
            180                 185                 190         


Ala Ala Ala Leu Ala Thr Gly Ala Cys Ile Val Gly Ile Leu Cys Leu 
        195                 200                 205             


Pro Leu Ile Leu Leu Leu Val Tyr Lys Gln Arg Gln Ala Ala Ser Asn 
    210                 215                 220                 


Arg Arg Ala Gln Glu Leu Val Arg Met Asp Ser Asn Ile Gln Gly Ile 
225                 230                 235                 240 


Glu Asn Pro Gly Phe Glu Ala Ser Pro Pro Ala Gln Gly Ile Pro Glu 
                245                 250                 255     


Ala Lys Val Arg His Pro Leu Ser Tyr Val Ala Gln Arg Gln Pro Ser 
            260                 265                 270         


Glu Ser Gly Arg His Leu Leu Ser Glu Pro Ser Thr Pro Leu Ser Pro 
        275                 280                 285             


Pro Gly Pro Gly Asp Val Phe Phe Pro Ser Leu Asp Pro Val Pro Asp 
    290                 295                 300                 


Ser Pro Asn Phe Glu Val Ile 
305                 310     


<210>  4889
<211>  460
<212>  PRT
<213>  Homo sapiens

<400>  4889

Met Ala Pro Gly Arg Ala Val Ala Gly Leu Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Gly Leu Gly Gly Val Ala Glu Gly Pro Gly Leu Ala Phe Ser Glu Asp 
            20                  25                  30          


Val Leu Ser Val Phe Gly Ala Asn Leu Ser Leu Ser Ala Ala Gln Leu 
        35                  40                  45              


Gln His Leu Leu Glu Gln Met Gly Ala Ala Ser Arg Val Gly Val Pro 
    50                  55                  60                  


Glu Pro Gly Gln Leu His Phe Asn Gln Cys Leu Thr Ala Glu Glu Ile 
65                  70                  75                  80  


Phe Ser Leu His Gly Phe Ser Asn Ala Thr Gln Ile Thr Ser Ser Lys 
                85                  90                  95      


Phe Ser Val Ile Cys Pro Ala Val Leu Gln Gln Leu Asn Phe His Pro 
            100                 105                 110         


Cys Glu Asp Arg Pro Lys His Lys Thr Arg Pro Ser His Ser Glu Val 
        115                 120                 125             


Trp Gly Tyr Gly Phe Leu Ser Val Thr Ile Ile Asn Leu Ala Ser Leu 
    130                 135                 140                 


Leu Gly Leu Ile Leu Thr Pro Leu Ile Lys Lys Ser Tyr Phe Pro Lys 
145                 150                 155                 160 


Ile Leu Thr Phe Phe Val Gly Leu Ala Ile Gly Thr Leu Phe Ser Asn 
                165                 170                 175     


Ala Ile Phe Gln Leu Ile Pro Glu Ala Phe Gly Phe Asp Pro Lys Val 
            180                 185                 190         


Asp Ser Tyr Val Glu Lys Ala Val Ala Val Phe Gly Gly Phe Tyr Leu 
        195                 200                 205             


Leu Phe Phe Phe Glu Arg Met Leu Lys Met Leu Leu Lys Thr Tyr Gly 
    210                 215                 220                 


Gln Asn Gly His Thr His Phe Gly Asn Asp Asn Phe Gly Pro Gln Glu 
225                 230                 235                 240 


Lys Thr His Gln Pro Lys Ala Leu Pro Ala Ile Asn Gly Val Thr Cys 
                245                 250                 255     


Tyr Ala Asn Pro Ala Val Thr Glu Ala Asn Gly His Ile His Phe Asp 
            260                 265                 270         


Asn Val Ser Val Val Ser Leu Gln Asp Gly Lys Lys Glu Pro Ser Ser 
        275                 280                 285             


Cys Thr Cys Leu Lys Gly Pro Lys Leu Ser Glu Ile Gly Thr Ile Ala 
    290                 295                 300                 


Trp Met Ile Thr Leu Cys Asp Ala Leu His Asn Phe Ile Asp Gly Leu 
305                 310                 315                 320 


Ala Ile Gly Ala Ser Cys Thr Leu Ser Leu Leu Gln Gly Leu Ser Thr 
                325                 330                 335     


Ser Ile Ala Ile Leu Cys Glu Glu Phe Pro His Glu Leu Gly Asp Phe 
            340                 345                 350         


Val Ile Leu Leu Asn Ala Gly Met Ser Thr Arg Gln Ala Leu Leu Phe 
        355                 360                 365             


Asn Phe Leu Ser Ala Cys Ser Cys Tyr Val Gly Leu Ala Phe Gly Ile 
    370                 375                 380                 


Leu Val Gly Asn Asn Phe Ala Pro Asn Ile Ile Phe Ala Leu Ala Gly 
385                 390                 395                 400 


Gly Met Phe Leu Tyr Ile Ser Leu Ala Asp Met Phe Pro Glu Met Asn 
                405                 410                 415     


Asp Met Leu Arg Glu Lys Val Thr Gly Arg Lys Thr Asp Phe Thr Phe 
            420                 425                 430         


Phe Met Ile Gln Asn Ala Gly Met Leu Thr Gly Phe Thr Ala Ile Leu 
        435                 440                 445             


Leu Ile Thr Leu Tyr Ala Gly Glu Ile Glu Leu Glu 
    450                 455                 460 


<210>  4890
<211>  690
<212>  PRT
<213>  Homo sapiens

<400>  4890

Met Lys Arg Leu Pro Leu Leu Val Val Phe Ser Thr Leu Leu Asn Cys 
1               5                   10                  15      


Ser Tyr Thr Gln Asn Cys Thr Lys Thr Pro Cys Leu Pro Asn Ala Lys 
            20                  25                  30          


Cys Glu Ile Arg Asn Gly Ile Glu Ala Cys Tyr Cys Asn Met Gly Phe 
        35                  40                  45              


Ser Gly Asn Gly Val Thr Ile Cys Glu Asp Asp Asn Glu Cys Gly Asn 
    50                  55                  60                  


Leu Thr Gln Ser Cys Gly Glu Asn Ala Asn Cys Thr Asn Thr Glu Gly 
65                  70                  75                  80  


Ser Tyr Tyr Cys Met Cys Val Pro Gly Phe Arg Ser Ser Ser Asn Gln 
                85                  90                  95      


Asp Arg Phe Ile Thr Asn Asp Gly Thr Val Cys Ile Glu Asn Val Asn 
            100                 105                 110         


Ala Asn Cys His Leu Asp Asn Val Cys Ile Ala Ala Asn Ile Asn Lys 
        115                 120                 125             


Thr Leu Thr Lys Ile Arg Ser Ile Lys Glu Pro Val Ala Leu Leu Gln 
    130                 135                 140                 


Glu Val Tyr Arg Asn Ser Val Thr Asp Leu Ser Pro Thr Asp Ile Ile 
145                 150                 155                 160 


Thr Tyr Ile Glu Ile Leu Ala Glu Ser Ser Ser Leu Leu Gly Tyr Lys 
                165                 170                 175     


Asn Asn Thr Ile Ser Ala Lys Asp Thr Leu Ser Asn Ser Thr Leu Thr 
            180                 185                 190         


Glu Phe Val Lys Thr Val Asn Asn Phe Val Gln Arg Asp Thr Phe Val 
        195                 200                 205             


Val Trp Asp Lys Leu Ser Val Asn His Arg Arg Thr His Leu Thr Lys 
    210                 215                 220                 


Leu Met His Thr Val Glu Gln Ala Thr Leu Arg Ile Ser Gln Ser Phe 
225                 230                 235                 240 


Gln Lys Thr Thr Glu Phe Asp Thr Asn Ser Thr Asp Ile Ala Leu Lys 
                245                 250                 255     


Val Phe Phe Phe Asp Ser Tyr Asn Met Lys His Ile His Pro His Met 
            260                 265                 270         


Asn Met Asp Gly Asp Tyr Ile Asn Ile Phe Pro Lys Arg Lys Ala Ala 
        275                 280                 285             


Tyr Asp Ser Asn Gly Asn Val Ala Val Ala Phe Val Tyr Tyr Lys Ser 
    290                 295                 300                 


Ile Gly Pro Leu Leu Ser Ser Ser Asp Asn Phe Leu Leu Lys Pro Gln 
305                 310                 315                 320 


Asn Tyr Asp Asn Ser Glu Glu Glu Glu Arg Val Ile Ser Ser Val Ile 
                325                 330                 335     


Ser Val Ser Met Ser Ser Asn Pro Pro Thr Leu Tyr Glu Leu Glu Lys 
            340                 345                 350         


Ile Thr Phe Thr Leu Ser His Arg Lys Val Thr Asp Arg Tyr Arg Ser 
        355                 360                 365             


Leu Cys Ala Phe Trp Asn Tyr Ser Pro Asp Thr Met Asn Gly Ser Trp 
    370                 375                 380                 


Ser Ser Glu Gly Cys Glu Leu Thr Tyr Ser Asn Glu Thr His Thr Ser 
385                 390                 395                 400 


Cys Arg Cys Asn His Leu Thr His Phe Ala Ile Leu Met Ser Ser Gly 
                405                 410                 415     


Pro Ser Ile Gly Ile Lys Asp Tyr Asn Ile Leu Thr Arg Ile Thr Gln 
            420                 425                 430         


Leu Gly Ile Ile Ile Ser Leu Ile Cys Leu Ala Ile Cys Ile Phe Thr 
        435                 440                 445             


Phe Trp Phe Phe Ser Glu Ile Gln Ser Thr Arg Thr Thr Ile His Lys 
    450                 455                 460                 


Asn Leu Cys Cys Ser Leu Phe Leu Ala Glu Leu Val Phe Leu Val Gly 
465                 470                 475                 480 


Ile Asn Thr Asn Thr Asn Lys Leu Phe Cys Ser Ile Ile Ala Gly Leu 
                485                 490                 495     


Leu His Tyr Phe Phe Leu Ala Ala Phe Ala Trp Met Cys Ile Glu Gly 
            500                 505                 510         


Ile His Leu Tyr Leu Ile Val Val Gly Val Ile Tyr Asn Lys Gly Phe 
        515                 520                 525             


Leu His Lys Asn Phe Tyr Ile Phe Gly Tyr Leu Ser Pro Ala Val Val 
    530                 535                 540                 


Val Gly Phe Ser Ala Ala Leu Gly Tyr Arg Tyr Tyr Gly Thr Thr Lys 
545                 550                 555                 560 


Val Cys Trp Leu Ser Thr Glu Asn Asn Phe Ile Trp Ser Phe Ile Gly 
                565                 570                 575     


Pro Ala Cys Leu Ile Ile Leu Val Asn Leu Leu Ala Phe Gly Val Ile 
            580                 585                 590         


Ile Tyr Lys Val Phe Arg His Thr Ala Gly Leu Lys Pro Glu Val Ser 
        595                 600                 605             


Cys Phe Glu Asn Ile Arg Ser Cys Ala Arg Gly Ala Leu Ala Leu Leu 
    610                 615                 620                 


Phe Leu Leu Gly Thr Thr Trp Ile Phe Gly Val Leu His Val Val His 
625                 630                 635                 640 


Ala Ser Val Val Thr Ala Tyr Leu Phe Thr Val Ser Asn Ala Phe Gln 
                645                 650                 655     


Gly Met Phe Ile Phe Leu Phe Leu Cys Val Leu Ser Arg Lys Ile Gln 
            660                 665                 670         


Glu Glu Tyr Tyr Arg Leu Phe Lys Asn Val Pro Cys Cys Phe Gly Cys 
        675                 680                 685             


Leu Arg 
    690 


<210>  4891
<211>  959
<212>  PRT
<213>  Homo sapiens

<400>  4891

Met Val Ala Ala Pro Cys Ala Arg Arg Leu Ala Arg Arg Ser His Ser 
1               5                   10                  15      


Ala Leu Leu Ala Ala Leu Thr Val Leu Leu Leu Gln Thr Leu Val Val 
            20                  25                  30          


Trp Asn Phe Ser Ser Leu Asp Ser Gly Ala Gly Glu Arg Arg Gly Gly 
        35                  40                  45              


Ala Ala Val Gly Gly Gly Glu Gln Pro Pro Pro Ala Pro Ala Pro Arg 
    50                  55                  60                  


Arg Glu Arg Arg Asp Leu Pro Ala Glu Pro Ala Ala Ala Arg Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Arg Gly Pro Gln Ala Arg 
                85                  90                  95      


Ala Arg Gly Gly Gly Pro Gly Glu Pro Arg Gly Gln Gln Pro Ala Ser 
            100                 105                 110         


Arg Gly Ala Leu Pro Ala Arg Ala Leu Asp Pro His Pro Ser Pro Leu 
        115                 120                 125             


Ile Thr Leu Glu Thr Gln Asp Gly Tyr Phe Ser His Arg Pro Lys Glu 
    130                 135                 140                 


Lys Val Arg Thr Asp Ser Asn Asn Glu Asn Ser Val Pro Lys Asp Phe 
145                 150                 155                 160 


Glu Asn Val Asp Asn Ser Asn Phe Ala Pro Arg Thr Gln Lys Gln Lys 
                165                 170                 175     


His Gln Pro Glu Leu Ala Lys Lys Pro Pro Ser Arg Gln Lys Glu Leu 
            180                 185                 190         


Leu Lys Arg Lys Leu Glu Gln Gln Glu Lys Gly Lys Gly His Thr Phe 
        195                 200                 205             


Pro Gly Lys Gly Pro Gly Glu Val Leu Pro Pro Gly Asp Arg Ala Ala 
    210                 215                 220                 


Ala Asn Ser Ser His Gly Lys Asp Val Ser Arg Pro Pro His Ala Arg 
225                 230                 235                 240 


Lys Thr Gly Gly Ser Ser Pro Glu Thr Lys Tyr Asp Gln Pro Pro Lys 
                245                 250                 255     


Cys Asp Ile Ser Gly Lys Glu Ala Ile Ser Ala Leu Ser Arg Ala Lys 
            260                 265                 270         


Ser Lys His Cys Arg Gln Glu Ile Gly Glu Thr Tyr Cys Arg His Lys 
        275                 280                 285             


Leu Gly Leu Leu Met Pro Glu Lys Val Thr Arg Phe Cys Pro Leu Glu 
    290                 295                 300                 


Gly Lys Ala Asn Lys Asn Val Gln Trp Asp Glu Asp Ser Val Glu Tyr 
305                 310                 315                 320 


Met Pro Ala Asn Pro Val Arg Ile Ala Phe Val Leu Val Val His Gly 
                325                 330                 335     


Arg Ala Ser Arg Gln Leu Gln Arg Met Phe Lys Ala Ile Tyr His Lys 
            340                 345                 350         


Asp His Phe Tyr Tyr Ile His Val Asp Lys Arg Ser Asn Tyr Leu His 
        355                 360                 365             


Arg Gln Val Leu Gln Val Ser Arg Gln Tyr Ser Asn Val Arg Val Thr 
    370                 375                 380                 


Pro Trp Arg Met Ala Thr Ile Trp Gly Gly Ala Ser Leu Leu Ser Thr 
385                 390                 395                 400 


Tyr Leu Gln Ser Met Arg Asp Leu Leu Glu Met Thr Asp Trp Pro Trp 
                405                 410                 415     


Asp Phe Phe Ile Asn Leu Ser Ala Ala Asp Tyr Pro Ile Arg Thr Asn 
            420                 425                 430         


Asp Gln Leu Val Ala Phe Leu Ser Arg Tyr Arg Asp Met Asn Phe Leu 
        435                 440                 445             


Lys Ser His Gly Arg Asp Asn Ala Arg Phe Ile Arg Lys Gln Gly Leu 
    450                 455                 460                 


Asp Arg Leu Phe Leu Glu Cys Asp Ala His Met Trp Arg Leu Gly Asp 
465                 470                 475                 480 


Arg Arg Ile Pro Glu Gly Ile Ala Val Asp Gly Gly Ser Asp Trp Phe 
                485                 490                 495     


Leu Leu Asn Arg Arg Phe Val Glu Tyr Val Thr Phe Ser Thr Asp Asp 
            500                 505                 510         


Leu Val Thr Lys Met Lys Gln Phe Tyr Ser Tyr Thr Leu Leu Pro Ala 
        515                 520                 525             


Glu Ser Phe Phe His Thr Val Leu Glu Asn Ser Pro His Cys Asp Thr 
    530                 535                 540                 


Met Val Asp Asn Asn Leu Arg Ile Thr Asn Trp Asn Arg Lys Leu Gly 
545                 550                 555                 560 


Cys Lys Cys Gln Tyr Lys His Ile Val Asp Trp Cys Gly Cys Ser Pro 
                565                 570                 575     


Asn Asp Phe Lys Pro Gln Asp Phe His Arg Phe Gln Gln Thr Ala Arg 
            580                 585                 590         


Pro Thr Phe Phe Ala Arg Lys Phe Glu Ala Val Val Asn Gln Glu Ile 
        595                 600                 605             


Ile Gly Gln Leu Asp Tyr Tyr Leu Tyr Gly Asn Tyr Pro Ala Gly Thr 
    610                 615                 620                 


Pro Gly Leu Arg Ser Tyr Trp Glu Asn Val Tyr Asp Glu Pro Asp Gly 
625                 630                 635                 640 


Ile His Ser Leu Ser Asp Val Thr Leu Thr Leu Tyr His Ser Phe Ala 
                645                 650                 655     


Arg Leu Gly Leu Arg Arg Ala Glu Thr Ser Leu His Thr Asp Gly Glu 
            660                 665                 670         


Asn Ser Cys Arg Tyr Tyr Pro Met Gly His Pro Ala Ser Val His Leu 
        675                 680                 685             


Tyr Phe Leu Ala Asp Arg Phe Gln Gly Phe Leu Ile Lys His His Ala 
    690                 695                 700                 


Thr Asn Leu Ala Val Ser Lys Leu Glu Thr Leu Glu Thr Trp Val Met 
705                 710                 715                 720 


Pro Lys Lys Val Phe Lys Ile Ala Ser Pro Pro Ser Asp Phe Gly Arg 
                725                 730                 735     


Leu Gln Phe Ser Glu Val Gly Thr Asp Trp Asp Ala Lys Glu Arg Leu 
            740                 745                 750         


Phe Arg Asn Phe Gly Gly Leu Leu Gly Pro Met Asp Glu Pro Val Gly 
        755                 760                 765             


Met Gln Lys Trp Gly Lys Gly Pro Asn Val Thr Val Thr Val Ile Trp 
    770                 775                 780                 


Val Asp Pro Val Asn Val Ile Ala Ala Thr Tyr Asp Ile Leu Ile Glu 
785                 790                 795                 800 


Ser Thr Ala Glu Phe Thr His Tyr Lys Pro Pro Leu Asn Leu Pro Leu 
                805                 810                 815     


Arg Pro Gly Val Trp Thr Val Lys Ile Leu His His Trp Val Pro Val 
            820                 825                 830         


Ala Glu Thr Lys Phe Leu Val Ala Pro Leu Thr Phe Ser Asn Arg Gln 
        835                 840                 845             


Pro Ile Lys Pro Glu Glu Ala Leu Lys Leu His Asn Gly Pro Leu Arg 
    850                 855                 860                 


Asn Ala Tyr Met Glu Gln Ser Phe Gln Ser Leu Asn Pro Val Leu Ser 
865                 870                 875                 880 


Leu Pro Ile Asn Pro Ala Gln Val Glu Gln Ala Arg Arg Asn Ala Ala 
                885                 890                 895     


Ser Thr Gly Thr Ala Leu Glu Gly Trp Leu Asp Ser Leu Val Gly Gly 
            900                 905                 910         


Met Trp Thr Ala Met Asp Ile Cys Ala Thr Gly Pro Thr Ala Cys Pro 
        915                 920                 925             


Val Met Gln Thr Cys Ser Gln Thr Ala Trp Ser Ser Phe Ser Pro Asp 
    930                 935                 940                 


Pro Lys Ser Glu Leu Gly Ala Val Lys Pro Asp Gly Arg Leu Arg 
945                 950                 955                 


<210>  4892
<211>  865
<212>  PRT
<213>  Homo sapiens

<400>  4892

Met Val Ala Ser Ala Arg Val Gln Lys Leu Val Arg Arg Tyr Lys Leu 
1               5                   10                  15      


Ala Ile Ala Thr Ala Leu Ala Ile Leu Leu Leu Gln Gly Leu Val Val 
            20                  25                  30          


Trp Ser Phe Ser Gly Leu Glu Glu Asp Glu Ala Gly Glu Lys Gly Arg 
        35                  40                  45              


Gln Arg Lys Pro Arg Pro Leu Asp Pro Gly Glu Gly Ser Lys Asp Thr 
    50                  55                  60                  


Asp Ser Ser Ala Gly Arg Arg Gly Ser Thr Gly Arg Arg His Gly Arg 
65                  70                  75                  80  


Trp Arg Gly Arg Ala Glu Ser Pro Gly Val Pro Val Ala Lys Val Val 
                85                  90                  95      


Arg Ala Val Thr Ser Arg Gln Arg Ala Ser Arg Arg Val Pro Pro Ala 
            100                 105                 110         


Pro Pro Pro Glu Ala Pro Gly Arg Gln Asn Leu Ser Gly Ala Ala Ala 
        115                 120                 125             


Gly Glu Ala Leu Val Gly Ala Ala Gly Phe Pro Pro His Gly Asp Thr 
    130                 135                 140                 


Gly Ser Val Glu Gly Ala Pro Gln Pro Thr Asp Asn Gly Phe Thr Pro 
145                 150                 155                 160 


Lys Cys Glu Ile Val Gly Lys Asp Ala Leu Ser Ala Leu Ala Arg Ala 
                165                 170                 175     


Ser Thr Lys Gln Cys Gln Gln Glu Ile Ala Asn Val Val Cys Leu His 
            180                 185                 190         


Gln Ala Gly Ser Leu Met Pro Lys Ala Val Pro Arg His Cys Gln Leu 
        195                 200                 205             


Thr Gly Lys Met Ser Pro Gly Ile Gln Trp Asp Glu Ser Gln Ala Gln 
    210                 215                 220                 


Gln Pro Met Asp Gly Pro Pro Val Arg Ile Ala Tyr Met Leu Val Val 
225                 230                 235                 240 


His Gly Arg Ala Ile Arg Gln Leu Lys Arg Leu Leu Lys Ala Val Tyr 
                245                 250                 255     


His Glu Gln His Phe Phe Tyr Ile His Val Asp Lys Arg Ser Asp Tyr 
            260                 265                 270         


Leu His Arg Glu Val Val Glu Leu Ala Gln Gly Tyr Asp Asn Val Arg 
        275                 280                 285             


Val Thr Pro Trp Arg Met Val Thr Ile Trp Gly Gly Ala Ser Leu Leu 
    290                 295                 300                 


Arg Met Tyr Leu Arg Ser Met Arg Asp Leu Leu Glu Val Pro Gly Trp 
305                 310                 315                 320 


Ala Trp Asp Phe Phe Ile Asn Leu Ser Ala Thr Asp Tyr Pro Thr Arg 
                325                 330                 335     


Thr Asn Glu Glu Leu Val Ala Phe Leu Ser Lys Asn Arg Asp Lys Asn 
            340                 345                 350         


Phe Leu Lys Ser His Gly Arg Asp Asn Ser Arg Phe Ile Lys Lys Gln 
        355                 360                 365             


Gly Leu Asp Arg Leu Phe His Glu Cys Asp Ser His Met Trp Arg Leu 
    370                 375                 380                 


Gly Glu Arg Gln Ile Pro Ala Gly Ile Val Val Asp Gly Gly Ser Asp 
385                 390                 395                 400 


Trp Phe Val Leu Thr Arg Ser Phe Val Glu Tyr Val Val Tyr Thr Asp 
                405                 410                 415     


Asp Pro Leu Val Ala Gln Leu Arg Gln Phe Tyr Thr Tyr Thr Leu Leu 
            420                 425                 430         


Pro Ala Glu Ser Phe Phe His Thr Val Leu Glu Asn Ser Leu Ala Cys 
        435                 440                 445             


Glu Thr Leu Val Asp Asn Asn Leu Arg Val Thr Asn Trp Asn Arg Lys 
    450                 455                 460                 


Leu Gly Cys Lys Cys Gln Tyr Lys His Ile Val Asp Trp Cys Gly Cys 
465                 470                 475                 480 


Ser Pro Asn Asp Phe Lys Pro Gln Asp Phe Leu Arg Leu Gln Gln Val 
                485                 490                 495     


Ser Arg Pro Thr Phe Phe Ala Arg Lys Phe Glu Ser Thr Val Asn Gln 
            500                 505                 510         


Glu Val Leu Glu Ile Leu Asp Phe His Leu Tyr Gly Ser Tyr Pro Pro 
        515                 520                 525             


Gly Thr Pro Ala Leu Lys Ala Tyr Trp Glu Asn Thr Tyr Asp Ala Ala 
    530                 535                 540                 


Asp Gly Pro Ser Gly Leu Ser Asp Val Met Leu Thr Ala Tyr Thr Ala 
545                 550                 555                 560 


Phe Ala Arg Leu Ser Leu His His Ala Ala Thr Ala Ala Pro Pro Met 
                565                 570                 575     


Gly Thr Pro Leu Cys Arg Phe Glu Pro Arg Gly Leu Pro Ser Ser Val 
            580                 585                 590         


His Leu Tyr Phe Tyr Asp Asp His Phe Gln Gly Tyr Leu Val Thr Gln 
        595                 600                 605             


Ala Val Gln Pro Ser Ala Gln Gly Pro Ala Glu Thr Leu Glu Met Trp 
    610                 615                 620                 


Leu Met Pro Gln Gly Ser Leu Lys Leu Leu Gly Arg Ser Asp Gln Ala 
625                 630                 635                 640 


Ser Arg Leu Gln Ser Leu Glu Val Gly Thr Asp Trp Asp Pro Lys Glu 
                645                 650                 655     


Arg Leu Phe Arg Asn Phe Gly Gly Leu Leu Gly Pro Leu Asp Glu Pro 
            660                 665                 670         


Val Ala Val Gln Arg Trp Ala Arg Gly Pro Asn Leu Thr Ala Thr Val 
        675                 680                 685             


Val Trp Ile Asp Pro Thr Tyr Val Val Ala Thr Ser Tyr Asp Ile Thr 
    690                 695                 700                 


Val Asp Thr Glu Thr Glu Val Thr Gln Tyr Lys Pro Pro Leu Ser Arg 
705                 710                 715                 720 


Pro Leu Arg Pro Gly Pro Trp Thr Val Arg Leu Leu Gln Phe Trp Glu 
                725                 730                 735     


Pro Leu Gly Glu Thr Arg Phe Leu Val Leu Pro Leu Thr Phe Asn Arg 
            740                 745                 750         


Lys Leu Pro Leu Arg Lys Asp Asp Ala Ser Trp Leu His Ala Gly Pro 
        755                 760                 765             


Pro His Asn Glu Tyr Met Glu Gln Ser Phe Gln Gly Leu Ser Ser Ile 
    770                 775                 780                 


Leu Asn Leu Pro Gln Pro Glu Leu Ala Glu Glu Ala Ala Gln Arg His 
785                 790                 795                 800 


Thr Gln Leu Thr Gly Pro Ala Leu Glu Ala Trp Thr Asp Arg Glu Leu 
                805                 810                 815     


Ser Ser Phe Trp Ser Val Ala Gly Leu Cys Ala Ile Gly Pro Ser Pro 
            820                 825                 830         


Cys Pro Ser Leu Glu Pro Cys Arg Leu Thr Ser Trp Ser Ser Leu Ser 
        835                 840                 845             


Pro Asp Pro Lys Ser Glu Leu Gly Pro Val Lys Ala Asp Gly Arg Leu 
    850                 855                 860                 


Arg 
865 


<210>  4893
<211>  646
<212>  PRT
<213>  Homo sapiens

<400>  4893

Met Ala Glu Lys Ala Leu Glu Ala Val Gly Cys Gly Leu Gly Pro Gly 
1               5                   10                  15      


Ala Val Ala Met Ala Val Thr Leu Glu Asp Gly Ala Glu Pro Pro Val 
            20                  25                  30          


Leu Thr Thr His Leu Lys Lys Val Glu Asn His Ile Thr Glu Ala Gln 
        35                  40                  45              


Arg Phe Ser His Leu Pro Lys Arg Ser Ala Val Asp Ile Glu Phe Val 
    50                  55                  60                  


Glu Leu Ser Tyr Ser Val Arg Glu Gly Pro Cys Trp Arg Lys Arg Gly 
65                  70                  75                  80  


Tyr Lys Thr Leu Leu Lys Cys Leu Ser Gly Lys Phe Cys Arg Arg Glu 
                85                  90                  95      


Leu Ile Gly Ile Met Gly Pro Ser Gly Ala Gly Lys Ser Thr Phe Met 
            100                 105                 110         


Asn Ile Leu Ala Gly Tyr Arg Glu Ser Gly Met Lys Gly Gln Ile Leu 
        115                 120                 125             


Val Asn Gly Arg Pro Arg Glu Leu Arg Thr Phe Arg Lys Met Ser Cys 
    130                 135                 140                 


Tyr Ile Met Gln Asp Asp Met Leu Leu Pro His Leu Thr Val Leu Glu 
145                 150                 155                 160 


Ala Met Met Val Ser Ala Asn Leu Lys Leu Ser Glu Lys Gln Glu Val 
                165                 170                 175     


Lys Lys Glu Leu Val Thr Glu Ile Leu Thr Ala Leu Gly Leu Met Ser 
            180                 185                 190         


Cys Ser His Thr Arg Thr Ala Leu Leu Ser Gly Gly Gln Arg Lys Arg 
        195                 200                 205             


Leu Ala Ile Ala Leu Glu Leu Val Asn Asn Pro Pro Val Met Phe Phe 
    210                 215                 220                 


Asp Glu Pro Thr Ser Gly Leu Asp Ser Ala Ser Cys Phe Gln Val Val 
225                 230                 235                 240 


Ser Leu Met Lys Ser Leu Ala Gln Gly Gly Arg Thr Ile Ile Cys Thr 
                245                 250                 255     


Ile His Gln Pro Ser Ala Lys Leu Phe Glu Met Phe Asp Lys Leu Tyr 
            260                 265                 270         


Ile Leu Ser Gln Gly Gln Cys Ile Phe Lys Gly Val Val Thr Asn Leu 
        275                 280                 285             


Ile Pro Tyr Leu Lys Gly Leu Gly Leu His Cys Pro Thr Tyr His Asn 
    290                 295                 300                 


Pro Ala Asp Phe Ile Ile Glu Val Ala Ser Gly Glu Tyr Gly Asp Leu 
305                 310                 315                 320 


Asn Pro Met Leu Phe Arg Ala Val Gln Asn Gly Leu Cys Ala Met Ala 
                325                 330                 335     


Glu Lys Lys Ser Ser Pro Glu Lys Asn Glu Val Pro Ala Pro Cys Pro 
            340                 345                 350         


Pro Cys Pro Pro Glu Val Asp Pro Ile Glu Ser His Thr Phe Ala Thr 
        355                 360                 365             


Ser Thr Leu Thr Gln Phe Cys Ile Leu Phe Lys Arg Thr Phe Leu Ser 
    370                 375                 380                 


Ile Leu Arg Asp Thr Val Leu Thr His Leu Arg Phe Met Ser His Val 
385                 390                 395                 400 


Val Ile Gly Val Leu Ile Gly Leu Leu Tyr Leu His Ile Gly Asp Asp 
                405                 410                 415     


Ala Ser Lys Val Phe Asn Asn Thr Gly Cys Leu Phe Phe Ser Met Leu 
            420                 425                 430         


Phe Leu Met Phe Ala Ala Leu Met Pro Thr Val Leu Thr Phe Pro Leu 
        435                 440                 445             


Glu Met Ala Val Phe Met Arg Glu His Leu Asn Tyr Trp Tyr Ser Leu 
    450                 455                 460                 


Lys Ala Tyr Tyr Leu Ala Lys Thr Met Ala Asp Val Pro Phe Gln Val 
465                 470                 475                 480 


Val Cys Pro Val Val Tyr Cys Ser Ile Val Tyr Trp Met Thr Gly Gln 
                485                 490                 495     


Pro Ala Glu Thr Ser Arg Phe Leu Leu Phe Ser Ala Leu Ala Thr Ala 
            500                 505                 510         


Thr Ala Leu Val Ala Gln Ser Leu Gly Leu Leu Ile Gly Ala Ala Ser 
        515                 520                 525             


Asn Ser Leu Gln Val Ala Thr Phe Val Gly Pro Val Thr Ala Ile Pro 
    530                 535                 540                 


Val Leu Leu Phe Ser Gly Phe Phe Val Ser Phe Lys Thr Ile Pro Thr 
545                 550                 555                 560 


Tyr Leu Gln Trp Ser Ser Tyr Leu Ser Tyr Val Arg Tyr Gly Phe Glu 
                565                 570                 575     


Gly Val Ile Leu Thr Ile Tyr Gly Met Glu Arg Gly Asp Leu Thr Cys 
            580                 585                 590         


Leu Glu Glu Arg Cys Pro Phe Arg Glu Pro Gln Ser Ile Leu Arg Ala 
        595                 600                 605             


Leu Asp Val Glu Asp Ala Lys Leu Tyr Met Asp Phe Leu Val Leu Gly 
    610                 615                 620                 


Ile Phe Phe Leu Ala Leu Arg Leu Leu Ala Tyr Leu Val Leu Arg Tyr 
625                 630                 635                 640 


Arg Val Lys Ser Glu Arg 
                645     


<210>  4894
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  4894

Met Ala Glu Ser Trp Ser Gly Gln Ala Leu Gln Ala Leu Pro Ala Thr 
1               5                   10                  15      


Val Leu Gly Ala Leu Gly Ser Glu Phe Leu Arg Glu Trp Glu Ala Gln 
            20                  25                  30          


Asp Met Arg Val Thr Leu Phe Lys Leu Leu Leu Leu Trp Leu Val Leu 
        35                  40                  45              


Ser Leu Leu Gly Ile Gln Leu Ala Trp Gly Phe Tyr Gly Asn Thr Val 
    50                  55                  60                  


Thr Gly Leu Tyr His Arg Pro Gly Leu Gly Gly Gln Asn Gly Ser Thr 
65                  70                  75                  80  


Pro Asp Gly Ser Thr His Phe Pro Ser Trp Glu Met Ala Ala Asn Glu 
                85                  90                  95      


Pro Leu Lys Thr His Arg Glu 
            100             


<210>  4895
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  4895

Met Ala Pro Asn Gly Thr Ala Ser Ser Phe Cys Leu Asp Ser Thr Ala 
1               5                   10                  15      


Cys Lys Ile Thr Ile Thr Val Val Leu Ala Val Leu Ile Leu Ile Thr 
            20                  25                  30          


Val Ala Gly Asn Val Val Val Cys Leu Ala Val Gly Leu Asn Arg Arg 
        35                  40                  45              


Leu Arg Asn Leu Thr Asn Cys Phe Ile Val Ser Leu Ala Ile Thr Asp 
    50                  55                  60                  


Leu Leu Leu Gly Leu Leu Val Leu Pro Phe Ser Ala Ile Tyr Gln Leu 
65                  70                  75                  80  


Ser Cys Lys Trp Ser Phe Gly Lys Val Phe Cys Asn Ile Tyr Thr Ser 
                85                  90                  95      


Leu Asp Val Met Leu Cys Thr Ala Ser Ile Leu Asn Leu Phe Met Ile 
            100                 105                 110         


Ser Leu Asp Arg Tyr Cys Ala Val Met Asp Pro Leu Arg Tyr Pro Val 
        115                 120                 125             


Leu Val Thr Pro Val Arg Val Ala Ile Ser Leu Val Leu Ile Trp Val 
    130                 135                 140                 


Ile Ser Ile Thr Leu Ser Phe Leu Ser Ile His Leu Gly Trp Asn Ser 
145                 150                 155                 160 


Arg Asn Glu Thr Ser Lys Gly Asn His Thr Thr Ser Lys Cys Lys Val 
                165                 170                 175     


Gln Val Asn Glu Val Tyr Gly Leu Val Asp Gly Leu Val Thr Phe Tyr 
            180                 185                 190         


Leu Pro Leu Leu Ile Met Cys Ile Thr Tyr Tyr Arg Ile Phe Lys Val 
        195                 200                 205             


Ala Arg Asp Gln Ala Lys Arg Ile Asn His Ile Ser Ser Trp Lys Ala 
    210                 215                 220                 


Ala Thr Ile Arg Glu His Lys Ala Thr Val Thr Leu Ala Ala Val Met 
225                 230                 235                 240 


Gly Ala Phe Ile Ile Cys Trp Phe Pro Tyr Phe Thr Ala Phe Val Tyr 
                245                 250                 255     


Arg Gly Leu Arg Gly Asp Asp Ala Ile Asn Glu Val Leu Glu Ala Ile 
            260                 265                 270         


Val Leu Trp Leu Gly Tyr Ala Asn Ser Ala Leu Asn Pro Ile Leu Tyr 
        275                 280                 285             


Ala Ala Leu Asn Arg Asp Phe Arg Thr Gly Tyr Gln Gln Leu Phe Cys 
    290                 295                 300                 


Cys Arg Leu Ala Asn Arg Asn Ser His Lys Thr Ser Leu Arg Ser Asn 
305                 310                 315                 320 


Ala Ser Gln Leu Ser Arg Thr Gln Ser Arg Glu Pro Arg Gln Gln Glu 
                325                 330                 335     


Glu Lys Pro Leu Lys Leu Gln Val Trp Ser Gly Thr Glu Val Thr Ala 
            340                 345                 350         


Pro Gln Gly Ala Thr Asp Arg 
        355                 


<210>  4896
<211>  483
<212>  PRT
<213>  Homo sapiens

<400>  4896

Met Ser Gly His Lys Cys Ser Tyr Pro Trp Asp Leu Gln Asp Arg Tyr 
1               5                   10                  15      


Ala Gln Asp Lys Ser Val Val Asn Lys Met Gln Gln Lys Tyr Trp Glu 
            20                  25                  30          


Thr Lys Gln Ala Phe Ile Lys Ala Thr Gly Lys Lys Glu Asp Glu His 
        35                  40                  45              


Val Val Ala Ser Asp Ala Asp Leu Asp Ala Lys Leu Glu Leu Phe His 
    50                  55                  60                  


Ser Ile Gln Arg Thr Cys Leu Asp Leu Ser Lys Ala Ile Val Leu Tyr 
65                  70                  75                  80  


Gln Lys Arg Ile Cys Phe Leu Ser Gln Glu Glu Asn Glu Leu Gly Lys 
                85                  90                  95      


Phe Leu Arg Ser Gln Gly Phe Gln Asp Lys Thr Arg Ala Gly Lys Met 
            100                 105                 110         


Met Gln Ala Thr Gly Lys Ala Leu Cys Phe Ser Ser Gln Gln Arg Leu 
        115                 120                 125             


Ala Leu Arg Asn Pro Leu Cys Arg Phe His Gln Glu Val Glu Thr Phe 
    130                 135                 140                 


Arg His Arg Ala Ile Ser Asp Thr Trp Leu Thr Val Asn Arg Met Glu 
145                 150                 155                 160 


Gln Cys Arg Thr Glu Tyr Arg Gly Ala Leu Leu Trp Met Lys Asp Val 
                165                 170                 175     


Ser Gln Glu Leu Asp Pro Asp Leu Tyr Lys Gln Met Glu Lys Phe Arg 
            180                 185                 190         


Lys Val Gln Thr Gln Val Arg Leu Ala Lys Lys Asn Phe Asp Lys Leu 
        195                 200                 205             


Lys Met Asp Val Cys Gln Lys Val Asp Leu Leu Gly Ala Ser Arg Cys 
    210                 215                 220                 


Asn Leu Leu Ser His Met Leu Ala Thr Tyr Gln Thr Thr Leu Leu His 
225                 230                 235                 240 


Phe Trp Glu Lys Thr Ser His Thr Met Ala Ala Ile His Glu Ser Phe 
                245                 250                 255     


Lys Gly Tyr Gln Pro Tyr Glu Phe Thr Thr Leu Lys Ser Leu Gln Asp 
            260                 265                 270         


Pro Met Lys Lys Leu Val Glu Lys Glu Glu Lys Lys Lys Ile Asn Gln 
        275                 280                 285             


Gln Glu Ser Thr Asp Ala Ala Val Gln Glu Pro Ser Gln Leu Ile Ser 
    290                 295                 300                 


Leu Glu Glu Glu Asn Gln Arg Lys Glu Ser Ser Ser Phe Lys Thr Glu 
305                 310                 315                 320 


Asp Gly Lys Ser Ile Leu Ser Ala Leu Asp Lys Gly Ser Thr His Thr 
                325                 330                 335     


Ala Cys Ser Gly Pro Ile Asp Glu Leu Leu Asp Met Lys Ser Glu Glu 
            340                 345                 350         


Gly Ala Cys Leu Gly Pro Val Ala Gly Thr Pro Glu Pro Glu Gly Ala 
        355                 360                 365             


Asp Lys Asp Asp Leu Leu Leu Leu Ser Glu Ile Phe Asn Ala Ser Ser 
    370                 375                 380                 


Leu Glu Glu Gly Glu Phe Ser Lys Glu Trp Ala Ala Val Phe Gly Asp 
385                 390                 395                 400 


Gly Gln Val Lys Glu Pro Val Pro Thr Met Ala Leu Gly Glu Pro Asp 
                405                 410                 415     


Pro Lys Ala Gln Thr Gly Ser Gly Phe Leu Pro Ser Gln Leu Leu Asp 
            420                 425                 430         


Gln Asn Met Lys Asp Leu Gln Ala Ser Leu Gln Glu Pro Ala Lys Ala 
        435                 440                 445             


Ala Ser Asp Leu Thr Ala Trp Phe Ser Leu Phe Ala Asp Leu Asp Pro 
    450                 455                 460                 


Leu Ser Asn Pro Asp Ala Val Gly Lys Thr Asp Lys Glu His Glu Leu 
465                 470                 475                 480 


Leu Asn Ala 
            


<210>  4897
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  4897

Met Ala His Val Gly Asp Cys Thr Gln Thr Pro Trp Leu Pro Val Leu 
1               5                   10                  15      


Val Val Ser Leu Met Cys Ser Ala Arg Ala Glu Tyr Ser Asn Cys Gly 
            20                  25                  30          


Glu Asn Glu Tyr Tyr Asn Gln Thr Thr Gly Leu Cys Gln Glu Cys Pro 
        35                  40                  45              


Pro Cys Gly Pro Gly Glu Glu Pro Tyr Leu Ser Cys Gly Tyr Gly Thr 
    50                  55                  60                  


Lys Asp Glu Asp Tyr Gly Cys Val Pro Cys Pro Ala Glu Lys Phe Ser 
65                  70                  75                  80  


Lys Gly Gly Tyr Gln Ile Cys Arg Arg His Lys Asp Cys Glu Gly Phe 
                85                  90                  95      


Phe Arg Ala Thr Val Leu Thr Pro Gly Asp Met Glu Asn Asp Ala Glu 
            100                 105                 110         


Cys Gly Pro Cys Leu Pro Gly Tyr Tyr Met Leu Glu Asn Arg Pro Arg 
        115                 120                 125             


Asn Ile Tyr Gly Met Val Cys Tyr Ser Cys Leu Leu Ala Pro Pro Asn 
    130                 135                 140                 


Thr Lys Glu Cys Val Gly Ala Thr Ser Gly Ala Ser Ala Asn Phe Pro 
145                 150                 155                 160 


Gly Thr Ser Gly Ser Ser Thr Leu Ser Pro Phe Gln His Ala His Lys 
                165                 170                 175     


Glu Leu Ser Gly Gln Gly His Leu Ala Thr Ala Leu Ile Ile Ala Met 
            180                 185                 190         


Ser Thr Ile Phe Ile Met Ala Ile Ala Ile Val Leu Ile Ile Met Phe 
        195                 200                 205             


Tyr Ile Leu Lys Thr Lys Pro Ser Ala Pro Ala Cys Cys Thr Ser His 
    210                 215                 220                 


Pro Gly Lys Ser Val Glu Ala Gln Val Ser Lys Asp Glu Glu Lys Lys 
225                 230                 235                 240 


Glu Ala Pro Asp Asn Val Val Met Phe Ser Glu Lys Asp Glu Phe Glu 
                245                 250                 255     


Lys Leu Thr Ala Thr Pro Ala Lys Pro Thr Lys Ser Glu Asn Asp Ala 
            260                 265                 270         


Ser Ser Glu Asn Glu Gln Leu Leu Ser Arg Ser Val Asp Ser Asp Glu 
        275                 280                 285             


Glu Pro Ala Pro Asp Lys Gln Gly Ser Pro Glu Leu Cys Leu Leu Ser 
    290                 295                 300                 


Leu Val His Leu Ala Arg Glu Lys Ser Ala Thr Ser Asn Lys Ser Ala 
305                 310                 315                 320 


Gly Ile Gln Ser Arg Arg Lys Lys Ile Leu Asp Val Tyr Ala Asn Val 
                325                 330                 335     


Cys Gly Val Val Glu Gly Leu Ser Pro Thr Glu Leu Pro Phe Asp Cys 
            340                 345                 350         


Leu Glu Lys Thr Ser Arg Met Leu Ser Ser Thr Tyr Asn Ser Glu Lys 
        355                 360                 365             


Ala Val Val Lys Thr Trp Arg His Leu Ala Glu Ser Phe Gly Leu Lys 
    370                 375                 380                 


Arg Asp Glu Ile Gly Gly Met Thr Asp Gly Met Gln Leu Phe Asp Arg 
385                 390                 395                 400 


Ile Ser Thr Ala Gly Tyr Ser Ile Pro Glu Leu Leu Thr Lys Leu Val 
                405                 410                 415     


Gln Ile Glu Arg Leu Asp Ala Val Glu Ser Leu Cys Ala Asp Ile Leu 
            420                 425                 430         


Glu Trp Ala Gly Val Val Pro Pro Ala Ser Gln Pro His Ala Ala Ser 
        435                 440                 445             


<210>  4898
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  4898

Met Trp Thr Ala Leu Val Leu Ile Trp Ile Phe Ser Leu Ser Leu Ser 
1               5                   10                  15      


Glu Ser His Ala Ala Ser Asn Asp Pro Arg Asn Phe Val Pro Asn Lys 
            20                  25                  30          


Met Trp Lys Gly Leu Val Lys Arg Asn Ala Ser Val Glu Thr Val Asp 
        35                  40                  45              


Asn Lys Thr Ser Glu Asp Val Thr Met Ala Ala Ala Ser Pro Val Thr 
    50                  55                  60                  


Leu Thr Lys Gly Thr Ser Ala Ala His Leu Asn Ser Met Glu Val Thr 
65                  70                  75                  80  


Thr Glu Asp Thr Ser Arg Thr Asp Val Ser Glu Pro Ala Thr Ser Gly 
                85                  90                  95      


Gly Ala Ala Asp Gly Val Thr Ser Ile Ala Pro Thr Ala Val Ala Ser 
            100                 105                 110         


Ser Thr Thr Ala Ala Ser Ile Thr Thr Ala Ala Ser Ser Met Thr Val 
        115                 120                 125             


Ala Ser Ser Ala Pro Thr Thr Ala Ala Ser Ser Thr Thr Val Ala Ser 
    130                 135                 140                 


Ile Ala Pro Thr Thr Ala Ala Ser Ser Met Thr Ala Ala Ser Ser Thr 
145                 150                 155                 160 


Pro Met Thr Leu Ala Leu Pro Ala Pro Thr Ser Thr Ser Thr Gly Arg 
                165                 170                 175     


Thr Pro Ser Thr Thr Ala Thr Gly His Pro Ser Leu Ser Thr Ala Leu 
            180                 185                 190         


Ala Gln Val Pro Lys Ser Ser Ala Leu Pro Arg Thr Ala Thr Leu Ala 
        195                 200                 205             


Thr Leu Ala Thr Arg Ala Gln Thr Val Ala Thr Thr Ala Asn Thr Ser 
    210                 215                 220                 


Ser Pro Met Ser Thr Arg Pro Ser Pro Ser Lys His Met Pro Ser Asp 
225                 230                 235                 240 


Thr Ala Ala Ser Pro Val Pro Pro Met Arg Pro Gln Ala Gln Gly Pro 
                245                 250                 255     


Ile Ser Gln Val Ser Val Asp Gln Pro Val Val Asn Thr Thr Asn Lys 
            260                 265                 270         


Ser Thr Pro Met Pro Ser Asn Thr Thr Pro Glu Pro Ala Pro Thr Pro 
        275                 280                 285             


Thr Val Val Thr Thr Thr Lys Ala Gln Ala Arg Glu Pro Thr Ala Ser 
    290                 295                 300                 


Pro Val Pro Val Pro His Thr Ser Pro Ile Pro Glu Met Glu Ala Met 
305                 310                 315                 320 


Ser Pro Thr Thr Gln Pro Ser Pro Met Pro Tyr Thr Gln Arg Ala Ala 
                325                 330                 335     


Gly Pro Gly Thr Ser Gln Ala Pro Glu Gln Val Glu Thr Glu Ala Thr 
            340                 345                 350         


Pro Gly Thr Asp Ser Thr Gly Pro Thr Pro Arg Ser Ser Gly Gly Thr 
        355                 360                 365             


Lys Met Pro Ala Thr Asp Ser Cys Gln Pro Ser Thr Gln Gly Gln Tyr 
    370                 375                 380                 


Met Val Val Thr Thr Glu Pro Leu Thr Gln Ala Val Val Asp Lys Thr 
385                 390                 395                 400 


Leu Leu Leu Val Val Leu Leu Leu Gly Val Thr Leu Phe Ile Thr Val 
                405                 410                 415     


Leu Val Leu Phe Ala Leu Gln Ala Tyr Glu Ser Tyr Lys Lys Lys Asp 
            420                 425                 430         


Tyr Thr Gln Val Asp Tyr Leu Ile Asn Gly Met Tyr Ala Asp Ser Glu 
        435                 440                 445             


Met 
    


<210>  4899
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  4899

Met Phe Ser Asp Asn Ser His Cys Pro Asp Cys Gly Gln Gln Trp Phe 
1               5                   10                  15      


Pro Ser Leu Glu Leu Gly His Trp Leu Tyr Gln Thr Glu Leu Val Glu 
            20                  25                  30          


Asn Glu Cys Tyr Gln Val Phe Leu Asp Arg Ile Asn Arg Ala Asp Tyr 
        35                  40                  45              


Cys Pro Glu Cys Tyr Pro Asp Asn Pro Ala Asn Arg Ser Leu Val Leu 
    50                  55                  60                  


Pro Trp Ser Phe Pro Leu Glu Trp Ala Pro Gln Asn Leu Thr Arg Trp 
65                  70                  75                  80  


Thr Phe Glu Lys Ala Cys His Pro Phe Leu Leu Gly Pro Pro Leu Val 
                85                  90                  95      


Arg Lys Arg Ile His Asp Ser Arg Val Ala Gly Phe Asn Pro Ala Leu 
            100                 105                 110         


Gln Leu Ile Leu Thr Arg Thr Asp Lys Thr Leu Asn Lys Lys Leu Gly 
        115                 120                 125             


Gln Asn Lys 
    130     


<210>  4900
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  4900

Met Thr Ser Gln Pro Val Pro Asn Glu Thr Ile Ile Val Leu Pro Ser 
1               5                   10                  15      


Asn Val Ile Asn Phe Ser Gln Ala Glu Lys Pro Glu Pro Thr Asn Gln 
            20                  25                  30          


Gly Gln Asp Ser Leu Lys Lys His Leu His Ala Glu Ile Lys Val Ile 
        35                  40                  45              


Gly Thr Ile Gln Ile Leu Cys Gly Met Met Val Leu Ser Leu Gly Ile 
    50                  55                  60                  


Ile Leu Ala Ser Ala Ser Phe Ser Pro Asn Phe Thr Gln Val Thr Ser 
65                  70                  75                  80  


Thr Leu Leu Asn Ser Ala Tyr Pro Phe Ile Gly Pro Phe Phe Phe Ile 
                85                  90                  95      


Ile Ser Gly Ser Leu Ser Ile Ala Thr Glu Lys Arg Leu Thr Lys Leu 
            100                 105                 110         


Leu Val His Ser Ser Leu Val Gly Ser Ile Leu Ser Ala Leu Ser Ala 
        115                 120                 125             


Leu Val Gly Phe Ile Ile Leu Ser Val Lys Gln Ala Thr Leu Asn Pro 
    130                 135                 140                 


Ala Ser Leu Gln Cys Glu Leu Asp Lys Asn Asn Ile Pro Thr Arg Ser 
145                 150                 155                 160 


Tyr Val Ser Tyr Phe Tyr His Asp Ser Leu Tyr Thr Thr Asp Cys Tyr 
                165                 170                 175     


Thr Ala Lys Ala Ser Leu Ala Gly Thr Leu Ser Leu Met Leu Ile Cys 
            180                 185                 190         


Thr Leu Leu Glu Phe Cys Leu Ala Val Leu Thr Ala Val Leu Arg Trp 
        195                 200                 205             


Lys Gln Ala Tyr Ser Asp Phe Pro Gly Val Ser Val Leu Ala Gly Phe 
    210                 215                 220                 


Thr 
225 


<210>  4901
<211>  486
<212>  PRT
<213>  Homo sapiens

<400>  4901

Met Gln Pro Ser Gly Leu Glu Gly Pro Gly Thr Phe Gly Arg Trp Pro 
1               5                   10                  15      


Leu Leu Ser Leu Leu Leu Leu Leu Leu Leu Leu Gln Pro Val Thr Cys 
            20                  25                  30          


Ala Tyr Thr Thr Pro Gly Pro Pro Arg Ala Leu Thr Thr Leu Gly Ala 
        35                  40                  45              


Pro Arg Ala His Thr Met Pro Gly Thr Tyr Ala Pro Ser Thr Thr Leu 
    50                  55                  60                  


Ser Ser Pro Ser Thr Gln Gly Leu Gln Glu Gln Ala Arg Ala Leu Met 
65                  70                  75                  80  


Arg Asp Phe Pro Leu Val Asp Gly His Asn Asp Leu Pro Leu Val Leu 
                85                  90                  95      


Arg Gln Val Tyr Gln Lys Gly Leu Gln Asp Val Asn Leu Arg Asn Phe 
            100                 105                 110         


Ser Tyr Gly Gln Thr Ser Leu Asp Arg Leu Arg Asp Gly Leu Val Gly 
        115                 120                 125             


Ala Gln Phe Trp Ser Ala Tyr Val Pro Cys Gln Thr Gln Asp Arg Asp 
    130                 135                 140                 


Ala Leu Arg Leu Thr Leu Glu Gln Ile Asp Leu Ile Arg Arg Met Cys 
145                 150                 155                 160 


Ala Ser Tyr Ser Glu Leu Glu Leu Val Thr Ser Ala Lys Ala Leu Asn 
                165                 170                 175     


Asp Thr Gln Lys Leu Ala Cys Leu Ile Gly Val Glu Gly Gly His Ser 
            180                 185                 190         


Leu Asp Asn Ser Leu Ser Ile Leu Arg Thr Phe Tyr Met Leu Gly Val 
        195                 200                 205             


Arg Tyr Leu Thr Leu Thr His Thr Cys Asn Thr Pro Trp Ala Glu Ser 
    210                 215                 220                 


Ser Ala Lys Gly Val His Ser Phe Tyr Asn Asn Ile Ser Gly Leu Thr 
225                 230                 235                 240 


Asp Phe Gly Glu Lys Val Val Ala Glu Met Asn Arg Leu Gly Met Met 
                245                 250                 255     


Val Asp Leu Ser His Val Ser Asp Ala Val Ala Arg Arg Ala Leu Glu 
            260                 265                 270         


Val Ser Gln Ala Pro Val Ile Phe Ser His Ser Ala Ala Arg Gly Val 
        275                 280                 285             


Cys Asn Ser Ala Arg Asn Val Pro Asp Asp Ile Leu Gln Leu Leu Lys 
    290                 295                 300                 


Lys Asn Gly Gly Val Val Met Val Ser Leu Ser Met Gly Val Ile Gln 
305                 310                 315                 320 


Cys Asn Pro Ser Ala Asn Val Ser Thr Val Ala Asp His Phe Asp His 
                325                 330                 335     


Ile Lys Ala Val Ile Gly Ser Lys Phe Ile Gly Ile Gly Gly Asp Tyr 
            340                 345                 350         


Asp Gly Ala Gly Lys Phe Pro Gln Gly Leu Glu Asp Val Ser Thr Tyr 
        355                 360                 365             


Pro Val Leu Ile Glu Glu Leu Leu Ser Arg Gly Trp Ser Glu Glu Glu 
    370                 375                 380                 


Leu Gln Gly Val Leu Arg Gly Asn Leu Leu Arg Val Phe Arg Gln Val 
385                 390                 395                 400 


Glu Lys Val Gln Glu Glu Asn Lys Trp Gln Ser Pro Leu Glu Asp Lys 
                405                 410                 415     


Phe Pro Asp Glu Gln Leu Ser Ser Ser Cys His Ser Asp Leu Ser Arg 
            420                 425                 430         


Leu Arg Gln Arg Gln Ser Leu Thr Ser Gly Gln Glu Leu Thr Glu Ile 
        435                 440                 445             


Pro Ile His Trp Thr Ala Lys Leu Pro Ala Lys Trp Ser Val Ser Glu 
    450                 455                 460                 


Ser Ser Pro His Met Ala Pro Val Leu Ala Val Val Ala Thr Phe Pro 
465                 470                 475                 480 


Val Leu Ile Leu Trp Leu 
                485     


<210>  4902
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  4902

Met Arg Arg Pro Ser Val Arg Ala Ala Gly Leu Val Leu Cys Thr Leu 
1               5                   10                  15      


Cys Tyr Leu Leu Val Gly Ala Ala Val Phe Asp Ala Leu Glu Ser Glu 
            20                  25                  30          


Ala Glu Ser Gly Arg Gln Arg Leu Leu Val Gln Lys Arg Gly Ala Leu 
        35                  40                  45              


Arg Arg Lys Phe Gly Phe Ser Ala Glu Asp Tyr Arg Glu Leu Glu Arg 
    50                  55                  60                  


Leu Ala Leu Gln Ala Glu Pro His Arg Ala Gly Arg Gln Trp Lys Phe 
65                  70                  75                  80  


Pro Gly Ser Phe Tyr Phe Ala Ile Thr Val Ile Thr Thr Ile Glu Tyr 
                85                  90                  95      


Gly His Ala Ala Pro Gly Thr Asp Ser Gly Lys Val Phe Cys Met Phe 
            100                 105                 110         


Tyr Ala Leu Leu Gly Ile Pro Leu Thr Leu Val Thr Phe Gln Ser Leu 
        115                 120                 125             


Gly Glu Arg Leu Asn Ala Val Val Arg Arg Leu Leu Leu Ala Ala Lys 
    130                 135                 140                 


Cys Cys Leu Gly Leu Arg Trp Thr Cys Val Ser Thr Glu Asn Leu Val 
145                 150                 155                 160 


Val Ala Gly Leu Leu Ala Cys Ala Ala Thr Leu Ala Leu Gly Ala Val 
                165                 170                 175     


Ala Phe Ser His Phe Glu Gly Trp Thr Phe Phe His Ala Tyr Tyr Tyr 
            180                 185                 190         


Cys Phe Ile Thr Leu Thr Thr Ile Gly Phe Gly Asp Phe Val Ala Leu 
        195                 200                 205             


Gln Ser Gly Glu Ala Leu Gln Arg Lys Leu Pro Tyr Val Ala Phe Ser 
    210                 215                 220                 


Phe Leu Tyr Ile Leu Leu Gly Leu Thr Val Ile Gly Ala Phe Leu Asn 
225                 230                 235                 240 


Leu Val Val Leu Arg Phe Leu Val Ala Ser Ala Asp Trp Pro Glu Arg 
                245                 250                 255     


Ala Ala Arg Thr Pro Ser Pro Arg Pro Pro Gly Ala Pro Glu Ser Arg 
            260                 265                 270         


Gly Leu Trp Leu Pro Arg Arg Pro Ala Arg Ser Val Gly Ser Ala Ser 
        275                 280                 285             


Val Phe Cys His Val His Lys Leu Glu Arg Cys Ala Arg Asp Asn Leu 
    290                 295                 300                 


Gly Phe Ser Pro Pro Ser Ser Pro Gly Val Val Arg Gly Gly Gln Ala 
305                 310                 315                 320 


Pro Arg Leu Gly Ala Arg Trp Lys Ser Ile 
                325                 330 


<210>  4903
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  4903

Met Ala Ser Ser Leu Lys Ile Trp Gly Thr Leu Leu Ala Leu Leu Cys 
1               5                   10                  15      


Ile Leu Cys Thr Leu Leu Val Gln Ser Lys Glu Val Ser Trp Arg Glu 
            20                  25                  30          


Phe Met Lys Gln His Tyr Leu Ser Pro Ser Arg Glu Phe Arg Glu Tyr 
        35                  40                  45              


Lys Cys Asp Val Leu Met Arg Glu Asn Glu Ala Leu Lys Asp Lys Ser 
    50                  55                  60                  


Ser His Met Phe Ile Tyr Ile Ser Trp Tyr Lys Ile Glu His Ile Cys 
65                  70                  75                  80  


Thr Ser Asp Asn Trp Met Asp Arg Phe Arg Asn Ala Tyr Val Trp Val 
                85                  90                  95      


Gln Asn Pro Leu Lys Val Leu Lys Cys His Gln Glu Asn Ser Lys Asn 
            100                 105                 110         


Ser Tyr Thr Glu Ser Arg Ser Phe Asn Tyr Ile Glu Phe His Cys Ser 
        115                 120                 125             


Met Asp Gly Tyr Val Asp Ser Ile Glu Asp Leu Lys Met Val Glu Pro 
    130                 135                 140                 


Ile Gly Asn 
145         


<210>  4904
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  4904

Met Glu Arg Asn Ser Ser Leu Trp Lys Asn Leu Ile Asp Glu His Pro 
1               5                   10                  15      


Val Cys Thr Thr Trp Lys Gln Glu Ala Glu Gly Ala Ile Tyr His Leu 
            20                  25                  30          


Ala Ser Ile Leu Phe Val Val Gly Phe Met Gly Gly Ser Gly Phe Phe 
        35                  40                  45              


Gly Leu Leu Tyr Val Phe Ser Leu Leu Gly Leu Gly Phe Leu Cys Ser 
    50                  55                  60                  


Ala Val Trp Ala Trp Val Asp Val Cys Ala Ala Asp Ile Phe Ser Trp 
65                  70                  75                  80  


Asn Phe Val Leu Phe Val Ile Cys Phe Met Gln Phe Val His Ile Ala 
                85                  90                  95      


Tyr Gln Val Arg Ser Ile Thr Phe Ala Arg Glu Phe Gln Val Leu Tyr 
            100                 105                 110         


Ser Ser Leu Phe Gln Pro Leu Gly Ile Ser Leu Pro Val Phe Arg Thr 
        115                 120                 125             


Ile Ala Leu Ser Ser Glu Val Val Thr Leu Glu Lys Glu His Cys Tyr 
    130                 135                 140                 


Ala Met Gln Gly Lys Thr Ser Ile Asp Lys Leu Ser Leu Leu Val Ser 
145                 150                 155                 160 


Gly Arg Ile Arg Val Thr Val Asp Gly Glu Phe Leu His Tyr Ile Phe 
                165                 170                 175     


Pro Leu Gln Phe Leu Asp Ser Pro Glu Trp Asp Ser Leu Arg Pro Thr 
            180                 185                 190         


Glu Glu Gly Ile Phe Gln Val Thr Leu Thr Ala Glu Thr Asp Cys Arg 
        195                 200                 205             


Tyr Val Ser Trp Arg Arg Lys Lys Leu Tyr Leu Leu Phe Ala Gln His 
    210                 215                 220                 


Arg Tyr Ile Ser Arg Leu Phe Ser Val Leu Ile Gly Ser Asp Ile Ala 
225                 230                 235                 240 


Asp Lys Leu Tyr Ala Leu Asn Asp Arg Val Tyr Ile Gly Lys Arg Tyr 
                245                 250                 255     


His Tyr Asp Ile Arg Leu Pro Asn Phe Tyr Gln Met Ser Thr Pro Glu 
            260                 265                 270         


Ile Arg Arg Ser Pro Leu Thr Gln His Phe Gln Asn Ser Arg Arg Tyr 
        275                 280                 285             


Cys Asp Lys 
    290     


<210>  4905
<211>  554
<212>  PRT
<213>  Homo sapiens

<400>  4905

Met Thr Ala Pro Cys Ser Gln Pro Ala Gln Leu Pro Gly Arg Arg Gln 
1               5                   10                  15      


Leu Gly Leu Val Pro Phe Pro Pro Pro Pro Pro Arg Thr Pro Leu Leu 
            20                  25                  30          


Trp Leu Leu Leu Leu Leu Leu Ala Ala Val Ala Pro Ala Arg Gly Trp 
        35                  40                  45              


Glu Ser Gly Asp Leu Glu Leu Phe Asp Leu Val Glu Glu Val Gln Leu 
    50                  55                  60                  


Asn Phe Tyr Gln Phe Leu Gly Val Gln Gln Asp Ala Ser Ser Ala Asp 
65                  70                  75                  80  


Ile Arg Lys Ala Tyr Arg Lys Leu Ser Leu Thr Leu His Pro Asp Lys 
                85                  90                  95      


Asn Lys Asp Glu Asn Ala Glu Thr Gln Phe Arg Gln Leu Val Ala Ile 
            100                 105                 110         


Tyr Glu Val Leu Lys Asp Asp Glu Arg Arg Gln Arg Tyr Asp Asp Ile 
        115                 120                 125             


Leu Ile Asn Gly Leu Pro Asp Trp Arg Gln Pro Val Phe Tyr Tyr Arg 
    130                 135                 140                 


Arg Val Arg Lys Met Ser Asn Ala Glu Leu Ala Leu Leu Leu Phe Ile 
145                 150                 155                 160 


Ile Leu Thr Val Gly His Tyr Ala Val Val Trp Ser Ile Tyr Leu Glu 
                165                 170                 175     


Lys Gln Leu Asp Glu Leu Leu Ser Arg Lys Lys Arg Glu Lys Lys Lys 
            180                 185                 190         


Lys Thr Gly Ser Lys Ser Val Asp Val Ser Lys Leu Gly Ala Ser Glu 
        195                 200                 205             


Lys Asn Glu Arg Leu Leu Met Lys Pro Gln Trp His Asp Leu Leu Pro 
    210                 215                 220                 


Cys Lys Leu Gly Ile Trp Phe Cys Leu Thr Leu Lys Ala Leu Pro His 
225                 230                 235                 240 


Leu Ile Gln Asp Ala Gly Gln Phe Tyr Ala Lys Tyr Lys Glu Thr Arg 
                245                 250                 255     


Leu Lys Glu Lys Glu Asp Ala Leu Thr Arg Thr Glu Leu Glu Thr Leu 
            260                 265                 270         


Gln Lys Gln Lys Lys Val Lys Lys Pro Lys Pro Glu Phe Pro Val Tyr 
        275                 280                 285             


Thr Pro Leu Glu Thr Thr Tyr Ile Gln Ser Tyr Asp His Gly Thr Ser 
    290                 295                 300                 


Ile Glu Glu Ile Glu Glu Gln Met Asp Asp Trp Leu Glu Asn Arg Asn 
305                 310                 315                 320 


Arg Thr Gln Lys Lys Gln Ala Pro Glu Trp Thr Glu Glu Asp Leu Ser 
                325                 330                 335     


Gln Leu Thr Arg Ser Met Val Lys Phe Pro Gly Gly Thr Pro Gly Arg 
            340                 345                 350         


Trp Glu Lys Ile Ala His Glu Leu Gly Arg Ser Val Thr Asp Val Thr 
        355                 360                 365             


Thr Lys Ala Lys Gln Leu Lys Asp Ser Val Thr Cys Ser Pro Gly Met 
    370                 375                 380                 


Val Arg Leu Ser Glu Leu Lys Ser Thr Val Gln Asn Ser Arg Pro Ile 
385                 390                 395                 400 


Lys Thr Ala Thr Thr Leu Pro Asp Asp Met Ile Thr Gln Arg Glu Asp 
                405                 410                 415     


Ala Glu Gly Val Ala Ala Glu Glu Glu Gln Glu Gly Asp Ser Gly Glu 
            420                 425                 430         


Gln Glu Thr Gly Ala Thr Asp Ala Arg Pro Arg Arg Arg Lys Pro Ala 
        435                 440                 445             


Arg Leu Leu Glu Ala Thr Ala Lys Pro Glu Pro Glu Glu Lys Ser Arg 
    450                 455                 460                 


Ala Lys Arg Gln Lys Asp Phe Asp Ile Ala Glu Gln Asn Glu Ser Ser 
465                 470                 475                 480 


Asp Glu Glu Ser Leu Arg Lys Glu Arg Ala Arg Ser Ala Glu Glu Pro 
                485                 490                 495     


Trp Thr Gln Asn Gln Gln Lys Leu Leu Glu Leu Ala Leu Gln Gln Tyr 
            500                 505                 510         


Pro Arg Gly Ser Ser Asp Arg Trp Asp Lys Ile Ala Arg Cys Val Pro 
        515                 520                 525             


Ser Lys Ser Lys Glu Asp Cys Ile Ala Arg Tyr Lys Leu Leu Val Glu 
    530                 535                 540                 


Leu Val Gln Lys Lys Lys Gln Ala Lys Ser 
545                 550                 


<210>  4906
<211>  761
<212>  PRT
<213>  Homo sapiens

<400>  4906

Met Ala Leu Pro Ala Leu Gly Leu Asp Pro Trp Ser Leu Leu Gly Leu 
1               5                   10                  15      


Phe Leu Phe Gln Leu Leu Gln Leu Leu Leu Pro Thr Thr Thr Ala Gly 
            20                  25                  30          


Gly Gly Gly Gln Gly Pro Met Pro Arg Val Arg Tyr Tyr Ala Gly Asp 
        35                  40                  45              


Glu Arg Arg Ala Leu Ser Phe Phe His Gln Lys Gly Leu Gln Asp Phe 
    50                  55                  60                  


Asp Thr Leu Leu Leu Ser Gly Asp Gly Asn Thr Leu Tyr Val Gly Ala 
65                  70                  75                  80  


Arg Glu Ala Ile Leu Ala Leu Asp Ile Gln Asp Pro Gly Val Pro Arg 
                85                  90                  95      


Leu Lys Asn Met Ile Pro Trp Pro Ala Ser Asp Arg Lys Lys Ser Glu 
            100                 105                 110         


Cys Ala Phe Lys Lys Lys Ser Asn Glu Thr Gln Cys Phe Asn Phe Ile 
        115                 120                 125             


Arg Val Leu Val Ser Tyr Asn Val Thr His Leu Tyr Thr Cys Gly Thr 
    130                 135                 140                 


Phe Ala Phe Ser Pro Ala Cys Thr Phe Ile Glu Leu Gln Asp Ser Tyr 
145                 150                 155                 160 


Leu Leu Pro Ile Ser Glu Asp Lys Val Met Glu Gly Lys Gly Gln Ser 
                165                 170                 175     


Pro Phe Asp Pro Ala His Lys His Thr Ala Val Leu Val Asp Gly Met 
            180                 185                 190         


Leu Tyr Ser Gly Thr Met Asn Asn Phe Leu Gly Ser Glu Pro Ile Leu 
        195                 200                 205             


Met Arg Thr Leu Gly Ser Gln Pro Val Leu Lys Thr Asp Asn Phe Leu 
    210                 215                 220                 


Arg Trp Leu His His Asp Ala Ser Phe Val Ala Ala Ile Pro Ser Thr 
225                 230                 235                 240 


Gln Val Val Tyr Phe Phe Phe Glu Glu Thr Ala Ser Glu Phe Asp Phe 
                245                 250                 255     


Phe Glu Arg Leu His Thr Ser Arg Val Ala Arg Val Cys Lys Asn Asp 
            260                 265                 270         


Val Gly Gly Glu Lys Leu Leu Gln Lys Lys Trp Thr Thr Phe Leu Lys 
        275                 280                 285             


Ala Gln Leu Leu Cys Thr Gln Pro Gly Gln Leu Pro Phe Asn Val Ile 
    290                 295                 300                 


Arg His Ala Val Leu Leu Pro Ala Asp Ser Pro Thr Ala Pro His Ile 
305                 310                 315                 320 


Tyr Ala Val Phe Thr Ser Gln Trp Gln Val Gly Gly Thr Arg Ser Ser 
                325                 330                 335     


Ala Val Cys Ala Phe Ser Leu Leu Asp Ile Glu Arg Val Phe Lys Gly 
            340                 345                 350         


Lys Tyr Lys Glu Leu Asn Lys Glu Thr Ser Arg Trp Thr Thr Tyr Arg 
        355                 360                 365             


Gly Pro Glu Thr Asn Pro Arg Pro Gly Ser Cys Ser Val Gly Pro Ser 
    370                 375                 380                 


Ser Asp Lys Ala Leu Thr Phe Met Lys Asp His Phe Leu Met Asp Glu 
385                 390                 395                 400 


Gln Val Val Gly Thr Pro Leu Leu Val Lys Ser Gly Val Glu Tyr Thr 
                405                 410                 415     


Arg Leu Ala Val Glu Thr Ala Gln Gly Leu Asp Gly His Ser His Leu 
            420                 425                 430         


Val Met Tyr Leu Gly Thr Thr Thr Gly Ser Leu His Lys Ala Val Val 
        435                 440                 445             


Ser Gly Asp Ser Ser Ala His Leu Val Glu Glu Ile Gln Leu Phe Pro 
    450                 455                 460                 


Asp Pro Glu Pro Val Arg Asn Leu Gln Leu Ala Pro Thr Gln Gly Ala 
465                 470                 475                 480 


Val Phe Val Gly Phe Ser Gly Gly Val Trp Arg Val Pro Arg Ala Asn 
                485                 490                 495     


Cys Ser Val Tyr Glu Ser Cys Val Asp Cys Val Leu Ala Arg Asp Pro 
            500                 505                 510         


His Cys Ala Trp Asp Pro Glu Ser Arg Thr Cys Cys Leu Leu Ser Ala 
        515                 520                 525             


Pro Asn Leu Asn Ser Trp Lys Gln Asp Met Glu Arg Gly Asn Pro Glu 
    530                 535                 540                 


Trp Ala Cys Ala Ser Gly Pro Met Ser Arg Ser Leu Arg Pro Gln Ser 
545                 550                 555                 560 


Arg Pro Gln Ile Ile Lys Glu Val Leu Ala Val Pro Asn Ser Ile Leu 
                565                 570                 575     


Glu Leu Pro Cys Pro His Leu Ser Ala Leu Ala Ser Tyr Tyr Trp Ser 
            580                 585                 590         


His Gly Pro Ala Ala Val Pro Glu Ala Ser Ser Thr Val Tyr Asn Gly 
        595                 600                 605             


Ser Leu Leu Leu Ile Val Gln Asp Gly Val Gly Gly Leu Tyr Gln Cys 
    610                 615                 620                 


Trp Ala Thr Glu Asn Gly Phe Ser Tyr Pro Val Ile Ser Tyr Trp Val 
625                 630                 635                 640 


Asp Ser Gln Asp Gln Thr Leu Ala Leu Asp Pro Glu Leu Ala Gly Ile 
                645                 650                 655     


Pro Arg Glu His Val Lys Val Pro Leu Thr Arg Val Ser Gly Gly Ala 
            660                 665                 670         


Ala Leu Ala Ala Gln Gln Ser Tyr Trp Pro His Phe Val Thr Val Thr 
        675                 680                 685             


Val Leu Phe Ala Leu Val Leu Ser Gly Ala Leu Ile Ile Leu Val Ala 
    690                 695                 700                 


Ser Pro Leu Arg Ala Leu Arg Ala Arg Gly Lys Val Gln Gly Cys Glu 
705                 710                 715                 720 


Thr Leu Arg Pro Gly Glu Lys Ala Pro Leu Ser Arg Glu Gln His Leu 
                725                 730                 735     


Gln Ser Pro Lys Glu Cys Arg Thr Ser Ala Ser Asp Val Asp Ala Asp 
            740                 745                 750         


Asn Asn Cys Leu Gly Thr Glu Val Ala 
        755                 760     


<210>  4907
<211>  1386
<212>  PRT
<213>  Homo sapiens

<400>  4907

Met Leu Arg Tyr Leu Leu Lys Thr Leu Leu Gln Met Asn Leu Phe Ala 
1               5                   10                  15      


Asp Ser Leu Ala Gly Asp Ile Ser Asn Ser Ser Glu Leu Leu Leu Gly 
            20                  25                  30          


Phe Asn Ser Ser Leu Ala Ala Leu Asn His Thr Leu Leu Pro Pro Gly 
        35                  40                  45              


Asp Pro Ser Leu Asn Gly Ser Arg Val Gly Pro Glu Asp Ala Met Pro 
    50                  55                  60                  


Arg Ile Val Glu Gln Pro Pro Asp Leu Leu Val Ser Arg Gly Glu Pro 
65                  70                  75                  80  


Ala Thr Leu Pro Cys Arg Ala Glu Gly Arg Pro Arg Pro Asn Ile Glu 
                85                  90                  95      


Trp Tyr Lys Asn Gly Ala Arg Val Ala Thr Val Arg Glu Asp Pro Arg 
            100                 105                 110         


Ala His Arg Leu Leu Leu Pro Ser Gly Ala Leu Phe Phe Pro Arg Ile 
        115                 120                 125             


Val His Gly Arg Arg Ala Arg Pro Asp Glu Gly Val Tyr Thr Cys Val 
    130                 135                 140                 


Ala Arg Asn Tyr Leu Gly Ala Ala Ala Ser Arg Asn Ala Ser Leu Glu 
145                 150                 155                 160 


Val Ala Val Leu Arg Asp Asp Phe Arg Gln Ser Pro Gly Asn Val Val 
                165                 170                 175     


Val Ala Val Gly Glu Pro Ala Val Leu Glu Cys Val Pro Pro Arg Gly 
            180                 185                 190         


His Pro Glu Pro Ser Val Ser Trp Arg Lys Asp Gly Ala Arg Leu Lys 
        195                 200                 205             


Glu Glu Glu Gly Arg Ile Thr Ile Arg Gly Gly Lys Leu Met Met Ser 
    210                 215                 220                 


His Thr Leu Lys Ser Asp Ala Gly Met Tyr Val Cys Val Ala Ser Asn 
225                 230                 235                 240 


Met Ala Gly Glu Arg Glu Ser Ala Ala Ala Glu Val Met Val Leu Glu 
                245                 250                 255     


Arg Pro Ser Phe Leu Arg Arg Pro Val Asn Gln Val Val Leu Ala Asp 
            260                 265                 270         


Ala Pro Val Thr Phe Leu Cys Glu Val Lys Gly Asp Pro Pro Pro Arg 
        275                 280                 285             


Leu Arg Trp Arg Lys Glu Asp Gly Glu Leu Pro Thr Gly Arg Tyr Glu 
    290                 295                 300                 


Ile Arg Ser Asp His Ser Leu Trp Ile Gly His Val Ser Ala Glu Asp 
305                 310                 315                 320 


Glu Gly Thr Tyr Thr Cys Val Ala Glu Asn Ser Val Gly Arg Ala Glu 
                325                 330                 335     


Ala Ser Gly Ser Leu Ser Val His Val Pro Pro Gln Leu Val Thr Gln 
            340                 345                 350         


Pro Gln Asp Gln Met Ala Ala Pro Gly Glu Ser Val Ala Phe Gln Cys 
        355                 360                 365             


Glu Thr Lys Gly Asn Pro Pro Pro Ala Ile Phe Trp Gln Lys Glu Gly 
    370                 375                 380                 


Ser Gln Val Leu Leu Phe Pro Ser Gln Ser Leu Gln Pro Thr Gly Arg 
385                 390                 395                 400 


Phe Ser Val Ser Pro Arg Gly Gln Leu Asn Ile Thr Ala Val Gln Arg 
                405                 410                 415     


Gly Asp Ala Gly Tyr Tyr Val Cys Gln Ala Val Ser Val Ala Gly Ser 
            420                 425                 430         


Ile Leu Ala Lys Ala Leu Leu Glu Ile Lys Gly Ala Ser Leu Asp Gly 
        435                 440                 445             


Leu Pro Pro Val Ile Leu Gln Gly Pro Ala Asn Gln Thr Leu Val Leu 
    450                 455                 460                 


Gly Ser Ser Val Trp Leu Pro Cys Arg Val Thr Gly Asn Pro Gln Pro 
465                 470                 475                 480 


Ser Val Arg Trp Lys Lys Asp Gly Gln Trp Leu Gln Gly Asp Asp Leu 
                485                 490                 495     


Gln Phe Lys Thr Met Ala Asn Gly Thr Leu Tyr Ile Ala Asn Val Gln 
            500                 505                 510         


Glu Met Asp Met Gly Phe Tyr Ser Cys Val Ala Lys Ser Ser Thr Gly 
        515                 520                 525             


Glu Ala Thr Trp Ser Gly Trp Leu Lys Met Arg Glu Asp Trp Gly Val 
    530                 535                 540                 


Ser Pro Asp Pro Pro Thr Glu Pro Ser Ser Pro Pro Gly Ala Pro Ser 
545                 550                 555                 560 


Gln Pro Val Val Thr Glu Ile Thr Lys Asn Ser Ile Thr Leu Thr Trp 
                565                 570                 575     


Lys Pro Asn Pro Gln Thr Gly Ala Ala Val Thr Ser Tyr Val Ile Glu 
            580                 585                 590         


Ala Phe Ser Pro Ala Ala Gly Asn Thr Trp Arg Thr Val Ala Asp Gly 
        595                 600                 605             


Val Gln Leu Glu Thr His Thr Val Ser Gly Leu Gln Pro Asn Thr Ile 
    610                 615                 620                 


Tyr Leu Phe Leu Val Arg Ala Val Gly Ala Trp Gly Leu Ser Glu Pro 
625                 630                 635                 640 


Ser Pro Val Ser Glu Pro Val Arg Thr Gln Asp Ser Ser Pro Ser Arg 
                645                 650                 655     


Pro Val Glu Asp Pro Trp Arg Gly Gln Gln Gly Leu Ala Glu Val Ala 
            660                 665                 670         


Val Arg Leu Gln Glu Pro Ile Val Leu Gly Pro Arg Thr Leu Gln Val 
        675                 680                 685             


Ser Trp Thr Val Asp Gly Pro Val Gln Leu Val Gln Gly Phe Arg Val 
    690                 695                 700                 


Ser Trp Arg Val Ala Gly Pro Glu Gly Gly Ser Trp Thr Met Leu Asp 
705                 710                 715                 720 


Leu Gln Ser Pro Ser Gln Gln Ser Thr Val Leu Arg Gly Leu Pro Pro 
                725                 730                 735     


Gly Thr Gln Ile Gln Ile Lys Val Gln Ala Gln Gly Gln Glu Gly Leu 
            740                 745                 750         


Gly Ala Glu Ser Leu Ser Val Thr Arg Ser Ile Pro Glu Glu Ala Pro 
        755                 760                 765             


Ser Gly Pro Pro Gln Gly Val Ala Val Ala Leu Gly Gly Asp Gly Asn 
    770                 775                 780                 


Ser Ser Ile Thr Val Ser Trp Glu Pro Pro Leu Pro Ser Gln Gln Asn 
785                 790                 795                 800 


Gly Val Ile Thr Glu Tyr Gln Ile Trp Cys Leu Gly Asn Glu Ser Arg 
                805                 810                 815     


Phe His Leu Asn Arg Ser Ala Ala Gly Trp Ala Arg Ser Ala Met Leu 
            820                 825                 830         


Arg Gly Leu Val Pro Gly Leu Leu Tyr Arg Thr Leu Val Ala Ala Ala 
        835                 840                 845             


Thr Ser Ala Gly Val Gly Val Pro Ser Ala Pro Val Leu Val Gln Leu 
    850                 855                 860                 


Pro Ser Pro Pro Asp Leu Glu Pro Gly Leu Glu Val Gly Ala Gly Leu 
865                 870                 875                 880 


Ala Val Arg Leu Ala Arg Val Leu Arg Glu Pro Ala Phe Leu Ala Gly 
                885                 890                 895     


Ser Gly Ala Ala Cys Gly Ala Leu Leu Leu Gly Leu Cys Ala Ala Leu 
            900                 905                 910         


Tyr Trp Arg Arg Lys Gln Arg Lys Glu Leu Ser His Tyr Thr Ala Ser 
        915                 920                 925             


Phe Ala Tyr Thr Pro Ala Val Ser Phe Pro His Ser Glu Gly Leu Ser 
    930                 935                 940                 


Gly Ala Ser Ser Arg Pro Pro Met Gly Leu Gly Pro Ala Pro Tyr Ser 
945                 950                 955                 960 


Trp Leu Ala Asp Ser Trp Pro His Pro Ser Arg Ser Pro Ser Ala Gln 
                965                 970                 975     


Glu Pro Arg Gly Ser Cys Cys Pro Ser Asn Pro Asp Pro Asp Asp Arg 
            980                 985                 990         


Tyr Tyr Asn Glu Ala Gly Ile Ser  Leu Tyr Leu Ala Gln  Thr Ala Arg 
        995                 1000                 1005             


Gly Thr  Ala Ala Pro Gly Glu  Gly Pro Val Tyr Ser  Thr Ile Asp 
    1010                 1015                 1020             


Pro Ala  Gly Glu Glu Leu Gln  Thr Phe His Gly Gly  Phe Pro Gln 
    1025                 1030                 1035             


His Pro  Ser Gly Asp Leu Gly  Pro Trp Ser Gln Tyr  Ala Pro Pro 
    1040                 1045                 1050             


Glu Trp  Ser Gln Gly Asp Ser  Gly Ala Lys Gly Gly  Lys Val Lys 
    1055                 1060                 1065             


Leu Leu  Gly Lys Pro Val Gln  Met Pro Ser Leu Asn  Trp Pro Glu 
    1070                 1075                 1080             


Ala Leu  Pro Pro Pro Pro Pro  Ser Cys Glu Leu Ser  Cys Leu Glu 
    1085                 1090                 1095             


Gly Pro  Glu Glu Glu Leu Glu  Gly Ser Ser Glu Pro  Glu Glu Trp 
    1100                 1105                 1110             


Cys Pro  Pro Met Pro Glu Arg  Ser His Leu Thr Glu  Pro Ser Ser 
    1115                 1120                 1125             


Ser Gly  Gly Cys Leu Val Thr  Pro Ser Arg Arg Glu  Thr Pro Ser 
    1130                 1135                 1140             


Pro Thr  Pro Ser Tyr Gly Gln  Gln Ser Thr Ala Thr  Leu Thr Pro 
    1145                 1150                 1155             


Ser Pro  Pro Asp Pro Pro Gln  Pro Pro Thr Asp Met  Pro His Leu 
    1160                 1165                 1170             


His Gln  Met Pro Arg Arg Val  Pro Leu Gly Pro Ser  Ser Pro Leu 
    1175                 1180                 1185             


Ser Val  Ser Gln Pro Met Leu  Gly Ile Arg Glu Ala  Arg Pro Ala 
    1190                 1195                 1200             


Gly Leu  Gly Ala Gly Pro Ala  Ala Ser Pro His Leu  Ser Pro Ser 
    1205                 1210                 1215             


Pro Ala  Pro Ser Thr Ala Ser  Ser Ala Pro Gly Arg  Thr Trp Gln 
    1220                 1225                 1230             


Gly Asn  Gly Glu Met Thr Pro  Pro Leu Gln Gly Pro  Arg Ala Arg 
    1235                 1240                 1245             


Phe Arg  Lys Lys Pro Lys Ala  Leu Pro Tyr Arg Arg  Glu Asn Ser 
    1250                 1255                 1260             


Pro Gly  Asp Leu Pro Pro Pro  Pro Leu Pro Pro Pro  Glu Glu Glu 
    1265                 1270                 1275             


Ala Ser  Trp Ala Leu Glu Leu  Arg Ala Ala Gly Ser  Met Ser Ser 
    1280                 1285                 1290             


Leu Glu  Arg Glu Arg Ser Gly  Glu Arg Lys Ala Val  Gln Ala Val 
    1295                 1300                 1305             


Pro Leu  Ala Ala Gln Arg Val  Leu His Pro Asp Glu  Glu Ala Trp 
    1310                 1315                 1320             


Leu Pro  Tyr Ser Arg Pro Ser  Phe Leu Ser Arg Gly  Gln Gly Thr 
    1325                 1330                 1335             


Ser Thr  Cys Ser Thr Ala Gly  Ser Asn Ser Ser Arg  Gly Ser Ser 
    1340                 1345                 1350             


Ser Ser  Arg Gly Ser Arg Gly  Pro Gly Arg Ser Arg  Ser Arg Ser 
    1355                 1360                 1365             


Gln Ser  Arg Ser Gln Ser Gln  Arg Pro Gly Gln Lys  Arg Arg Glu 
    1370                 1375                 1380             


Glu Pro  Arg 
    1385     


<210>  4908
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  4908

Met Asp Gln Ser Gly Met Glu Ile Pro Val Thr Leu Ile Ile Lys Ala 
1               5                   10                  15      


Pro Asn Gln Lys Tyr Ser Asp Gln Thr Ile Ser Cys Phe Leu Asn Trp 
            20                  25                  30          


Thr Val Gly Lys Leu Lys Thr His Leu Ser Asn Val Tyr Pro Ser Lys 
        35                  40                  45              


Pro Leu Thr Lys Asp Gln Arg Leu Val Tyr Ser Gly Arg Leu Leu Pro 
    50                  55                  60                  


Asp His Leu Gln Leu Lys Asp Ile Leu Arg Lys Gln Asp Glu Tyr His 
65                  70                  75                  80  


Met Val His Leu Val Cys Thr Ser Arg Thr Pro Pro Ser Ser Pro Lys 
                85                  90                  95      


Ser Ser Thr Asn Arg Glu Ser His Glu Ala Leu Ala Ser Ser Ser Asn 
            100                 105                 110         


Ser Ser Ser Asp His Ser Gly Ser Thr Thr Pro Ser Ser Gly Gln Glu 
        115                 120                 125             


Thr Leu Ser Leu Ala Val Gly Ser Ser Ser Glu Gly Leu Arg Gln Arg 
    130                 135                 140                 


Thr Leu Pro Gln Ala Gln Thr Asp Gln Ala Gln Ser His Gln Phe Pro 
145                 150                 155                 160 


Tyr Val Met Gln Gly Asn Val Asp Asn Gln Phe Pro Gly Gln Ala Ala 
                165                 170                 175     


Pro Pro Gly Phe Pro Val Tyr Pro Ala Phe Ser Pro Leu Gln Met Leu 
            180                 185                 190         


Trp Trp Gln Gln Met Tyr Ala His Gln Tyr Tyr Met Gln Tyr Gln Ala 
        195                 200                 205             


Ala Val Ser Ala Gln Ala Thr Ser Asn Val Asn Pro Thr Gln Pro Thr 
    210                 215                 220                 


Thr Ser Gln Pro Leu Asn Leu Ala His Val Pro Gly Glu Glu Pro Pro 
225                 230                 235                 240 


Pro Ala Pro Asn Leu Val Ala Gln Glu Asn Arg Pro Met Asn Glu Asn 
                245                 250                 255     


Val Gln Met Asn Ala Gln Gly Gly Pro Val Leu Asn Glu Glu Asp Phe 
            260                 265                 270         


Asn Arg Asp Trp Leu Asp Trp Met Tyr Thr Phe Ser Arg Ala Ala Ile 
        275                 280                 285             


Leu Leu Ser Ile Val Tyr Phe Tyr Ser Ser Phe Ser Arg Phe Ile Met 
    290                 295                 300                 


Val Met Gly Ala Met Leu Leu Val Tyr Leu His Gln Ala Gly Trp Phe 
305                 310                 315                 320 


Pro Phe Arg Gln Glu Gly Gly His Gln Gln Ala Pro Asn Asn Asn Ala 
                325                 330                 335     


Glu Val Asn Asn Asp Gly Gln Asn Ala Asn Asn Leu Glu Leu Glu Glu 
            340                 345                 350         


Met Glu Arg Leu Met Asp Asp Gly Leu Glu Asp Glu Ser Gly Glu Asp 
        355                 360                 365             


Gly Gly Glu Asp Ala Ser Ala Ile Gln Arg Pro Gly Leu Met Ala Ser 
    370                 375                 380                 


Ala Trp Ser Phe Ile Thr Thr Phe Phe Thr Ser Leu Ile Pro Glu Gly 
385                 390                 395                 400 


Pro Pro Gln Val Ala Asn 
                405     


<210>  4909
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  4909

Met Ala Glu Gly Asp Glu Ala Ala Arg Gly Gln Gln Pro His Gln Gly 
1               5                   10                  15      


Leu Trp Arg Arg Arg Arg Thr Ser Asp Pro Ser Ala Ala Val Asn His 
            20                  25                  30          


Val Ser Ser Thr Thr Ser Leu Gly Glu Asn Tyr Glu Asp Asp Asp Leu 
        35                  40                  45              


Val Asn Ser Asp Glu Val Met Lys Lys Pro Cys Pro Val Gln Ile Val 
    50                  55                  60                  


Leu Ala His Glu Asp Asp His Asn Phe Glu Leu Asp Glu Glu Ala Leu 
65                  70                  75                  80  


Glu Gln Ile Leu Leu Gln Glu His Ile Arg Asp Leu Asn Ile Val Val 
                85                  90                  95      


Val Ser Val Ala Gly Ala Phe Arg Lys Gly Lys Ser Phe Leu Leu Asp 
            100                 105                 110         


Phe Met Leu Arg Tyr Met Tyr Asn Lys Asp Ser Gln Ser Trp Ile Gly 
        115                 120                 125             


Gly Asn Asn Glu Pro Leu Thr Gly Phe Thr Trp Arg Gly Gly Cys Glu 
    130                 135                 140                 


Arg Glu Thr Thr Gly Ile Gln Val Trp Asn Glu Val Phe Val Ile Asp 
145                 150                 155                 160 


Arg Pro Asn Gly Thr Lys Val Ala Val Leu Leu Met Asp Thr Gln Gly 
                165                 170                 175     


Ala Phe Asp Ser Gln Ser Thr Ile Lys Asp Cys Ala Thr Val Phe Ala 
            180                 185                 190         


Leu Ser Thr Met Thr Ser Ser Val Gln Val Tyr Asn Leu Ser Gln Asn 
        195                 200                 205             


Ile Gln Glu Asp Asp Leu Gln His Leu Gln Leu Phe Thr Glu Tyr Gly 
    210                 215                 220                 


Arg Leu Ala Met Glu Glu Ile Tyr Gln Lys Pro Phe Gln Thr Leu Met 
225                 230                 235                 240 


Phe Leu Ile Arg Asp Trp Ser Tyr Pro Tyr Glu His Ser Tyr Gly Leu 
                245                 250                 255     


Glu Gly Gly Lys Gln Phe Leu Glu Lys Arg Leu Gln Val Lys Gln Asn 
            260                 265                 270         


Gln His Glu Glu Leu Gln Asn Val Arg Lys His Ile His Asn Cys Phe 
        275                 280                 285             


Ser Asn Leu Gly Cys Phe Leu Leu Pro His Pro Gly Leu Lys Val Ala 
    290                 295                 300                 


Thr Asn Pro Ser Phe Asp Gly Arg Leu Lys Asp Ile Asp Glu Asp Phe 
305                 310                 315                 320 


Lys Arg Glu Leu Arg Asn Leu Val Pro Leu Leu Leu Ala Pro Glu Asn 
                325                 330                 335     


Leu Val Glu Lys Glu Ile Ser Gly Ser Lys Val Thr Cys Arg Asp Leu 
            340                 345                 350         


Val Glu Tyr Phe Lys Ala Tyr Ile Lys Ile Tyr Gln Gly Glu Glu Leu 
        355                 360                 365             


Pro His Pro Lys Ser Met Leu Gln Ala Thr Ala Glu Ala Asn Asn Leu 
    370                 375                 380                 


Ala Ala Val Ala Gly Ala Arg Asp Thr Tyr Cys Lys Ser Met Glu Gln 
385                 390                 395                 400 


Val Cys Gly Gly Asp Lys Pro Tyr Ile Ala Pro Ser Asp Leu Glu Arg 
                405                 410                 415     


Lys His Leu Asp Leu Lys Glu Val Ala Ile Lys Gln Phe Arg Ser Val 
            420                 425                 430         


Lys Lys Met Gly Gly Asp Glu Phe Cys Arg Arg Tyr Gln Asp Gln Leu 
        435                 440                 445             


Glu Ala Glu Ile Glu Glu Thr Tyr Ala Asn Phe Ile Lys His Asn Asp 
    450                 455                 460                 


Gly Lys Asn Ile Phe Tyr Ala Ala Arg Thr Pro Ala Thr Leu Phe Ala 
465                 470                 475                 480 


Val Met Phe Ala Met Tyr Ile Ile Ser Gly Leu Thr Gly Phe Ile Gly 
                485                 490                 495     


Leu Asn Ser Ile Ala Val Leu Cys Asn Leu Val Met Gly Leu Ala Leu 
            500                 505                 510         


Ile Phe Leu Cys Thr Trp Ala Tyr Val Lys Tyr Ser Gly Glu Phe Arg 
        515                 520                 525             


Glu Ile Gly Thr Val Ile Asp Gln Ile Ala Glu Thr Leu Trp Glu Gln 
    530                 535                 540                 


Val Phe Ser Lys Leu Phe Glu Val Thr Arg Arg Arg Met Val His Arg 
545                 550                 555                 560 


Ala Leu Ser Ser Ala Gln Arg Gln Arg Leu Ser Ser Asn Asn Asn Lys 
                565                 570                 575     


Lys Lys Asn 
            


<210>  4910
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  4910

Met Gly Met Tyr Pro Pro Leu Leu Leu Lys Ile Tyr Leu Ser Arg His 
1               5                   10                  15      


Ile Ser Ile Leu Phe Tyr Leu Lys Ile Leu Tyr Lys Ser Gly Ile Ile 
            20                  25                  30          


Trp Leu Ser Trp Tyr Ser Phe Ile Leu Leu Val Leu 
        35                  40                  


<210>  4911
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  4911

Met Gly Ser Leu Phe Pro Leu Ser Leu Leu Phe Phe Leu Ala Ala Ala 
1               5                   10                  15      


Tyr Pro Gly Val Gly Ser Ala Leu Gly Arg Arg Thr Lys Arg Ala Gln 
            20                  25                  30          


Ser Pro Lys Gly Ser Pro Leu Ala Pro Ser Gly Thr Ser Val Pro Phe 
        35                  40                  45              


Trp Val Arg Met Ser Pro Glu Phe Val Ala Val Gln Pro Gly Lys Ser 
    50                  55                  60                  


Val Gln Leu Asn Cys Ser Asn Ser Cys Pro Gln Pro Gln Asn Ser Ser 
65                  70                  75                  80  


Leu Arg Thr Pro Leu Arg Gln Gly Lys Thr Leu Arg Gly Pro Gly Trp 
                85                  90                  95      


Val Ser Tyr Gln Leu Leu Asp Val Arg Ala Trp Ser Ser Leu Ala His 
            100                 105                 110         


Cys Leu Val Thr Cys Ala Gly Lys Thr Arg Trp Ala Thr Ser Arg Ile 
        115                 120                 125             


Thr Ala Tyr Lys Pro Pro His Ser Val Ile Leu Glu Pro Pro Val Leu 
    130                 135                 140                 


Lys Gly Arg Lys Tyr Thr Leu Arg Cys His Val Thr Gln Val Phe Pro 
145                 150                 155                 160 


Val Gly Tyr Leu Val Val Thr Leu Arg His Gly Ser Arg Val Ile Tyr 
                165                 170                 175     


Ser Glu Ser Leu Glu Arg Phe Thr Gly Leu Asp Leu Ala Asn Val Thr 
            180                 185                 190         


Leu Thr Tyr Glu Phe Ala Ala Gly Pro Arg Asp Phe Trp Gln Pro Val 
        195                 200                 205             


Ile Cys His Ala Arg Leu Asn Leu Asp Gly Leu Val Val Arg Asn Ser 
    210                 215                 220                 


Ser Ala Pro Ile Thr Leu Met Leu Gly Glu Ala Pro Leu 
225                 230                 235         


<210>  4912
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  4912

Met Glu Lys Ala Arg Pro Leu Trp Ala Asn Ser Leu Gln Phe Val Phe 
1               5                   10                  15      


Ala Cys Ile Ser Tyr Ala Val Gly Leu Gly Asn Val Trp Arg Phe Pro 
            20                  25                  30          


Tyr Leu Cys Gln Met Tyr Gly Gly Gly Ser Phe Leu Val Pro Tyr Ile 
        35                  40                  45              


Ile Met Leu Ile Val Glu Gly Met Pro Leu Leu Tyr Leu Glu Leu Ala 
    50                  55                  60                  


Val Gly Gln Arg Met Arg Gln Gly Ser Ile Gly Ala Trp Arg Thr Ile 
65                  70                  75                  80  


Ser Pro Tyr Leu Ser Gly Val Gly Val Ala Ser Val Val Val Ser Phe 
                85                  90                  95      


Phe Leu Ser Met Tyr Tyr Asn Val Ile Asn Ala Trp Ala Phe Trp Tyr 
            100                 105                 110         


Leu Phe His Ser Phe Gln Asp Pro Leu Pro Trp Ser Val Cys Pro Leu 
        115                 120                 125             


Asn Gly Asn His Thr Gly Tyr Asp Glu Glu Cys Glu Lys Ala Ser Ser 
    130                 135                 140                 


Thr Gln Tyr Phe Trp Tyr Arg Lys Thr Leu Asn Ile Ser Pro Ser Leu 
145                 150                 155                 160 


Gln Glu Asn Gly Gly Val Gln Trp Glu Pro Ala Leu Cys Leu Leu Leu 
                165                 170                 175     


Ala Trp Leu Val Val Tyr Leu Cys Ile Leu Arg Gly Thr Glu Ser Thr 
            180                 185                 190         


Gly Lys Ile Glu Gln Leu Ala Asn Pro Lys Ala Trp Ile Asn Ala Ala 
        195                 200                 205             


Thr Gln Ile Phe Phe Ser Leu Gly Leu Gly Phe Gly Ser Leu Ile Ala 
    210                 215                 220                 


Phe Ala Ser Tyr Asn Glu Pro Ser Asn Asn Cys Gln Lys His Ala Ile 
225                 230                 235                 240 


Ile Val Ser Leu Ile Asn Ser Phe Thr Ser Ile Phe Ala Ser Ile Val 
                245                 250                 255     


Thr Phe Ser Ile Tyr Gly Phe Lys Ala Thr Phe Asn Tyr Glu Asn Cys 
            260                 265                 270         


Leu Lys Lys Val Ser Leu Leu Leu Thr Asn Thr Phe Asp Leu Glu Asp 
        275                 280                 285             


Gly Phe Leu Thr Ala Ser Asn Leu Glu Gln Val Lys Gly Tyr Leu Ala 
    290                 295                 300                 


Ser Ala Tyr Pro Ser Lys Tyr Ser Glu Met Phe Pro Gln Ile Lys Asn 
305                 310                 315                 320 


Cys Ser Leu Glu Ser Glu Leu Asp Thr Ala Val Gln Gly Thr Gly Leu 
                325                 330                 335     


Ala Phe Ile Val Tyr Thr Glu Ala Ile Lys Asn Met Glu Val Ser Gln 
            340                 345                 350         


Leu Trp Ser Val Leu Tyr Phe Phe Met Leu Leu Met Leu Gly Ile Gly 
        355                 360                 365             


Ser Met Leu Gly Asn Thr Ala Ala Ile Leu Thr Pro Leu Thr Asp Ser 
    370                 375                 380                 


Lys Ile Ile Ser Ser His Leu Pro Lys Glu Ala Ile Ser Gly Leu Val 
385                 390                 395                 400 


Cys Leu Val Asn Cys Ala Ile Gly Met Val Phe Thr Met Glu Ala Gly 
                405                 410                 415     


Asn Tyr Trp Phe Asp Ile Phe Asn Asp Tyr Ala Ala Thr Leu Ser Leu 
            420                 425                 430         


Leu Leu Ile Val Leu Val Glu Thr Ile Ala Val Cys Tyr Val Tyr Gly 
        435                 440                 445             


Leu Arg Arg Phe Glu Ser Asp Leu Lys Ala Met Thr Gly Arg Ala Val 
    450                 455                 460                 


Ser Trp Tyr Trp Lys Val Met Trp Ala Gly Val Ser Pro Leu Leu Ile 
465                 470                 475                 480 


Val Ser Leu Phe Val Phe Tyr Leu Ser Asp Tyr Ile Leu Thr Gly Thr 
                485                 490                 495     


Leu Lys Tyr Gln Ala Trp Asp Ala Ser Gln Gly Gln Leu Val Thr Lys 
            500                 505                 510         


Asp Tyr Pro Ala Tyr Ala Leu Ala Val Ile Gly Leu Leu Val Ala Ser 
        515                 520                 525             


Ser Thr Met Cys Ile Pro Leu Ala Ala Leu Gly Thr Phe Val Gln Arg 
    530                 535                 540                 


Arg Leu Lys Arg Gly Asp Ala Asp Pro Val Ala 
545                 550                 555 


<210>  4913
<211>  673
<212>  PRT
<213>  Homo sapiens

<400>  4913

Met Ala Gly Lys Ala Ala Glu Glu Arg Gly Leu Pro Lys Gly Ala Thr 
1               5                   10                  15      


Pro Gln Asp Thr Ser Gly Leu Gln Asp Arg Leu Phe Ser Ser Glu Ser 
            20                  25                  30          


Asp Asn Ser Leu Tyr Phe Thr Tyr Ser Gly Gln Pro Asn Thr Leu Glu 
        35                  40                  45              


Val Arg Asp Leu Asn Tyr Gln Val Asp Leu Ala Ser Gln Val Pro Trp 
    50                  55                  60                  


Phe Glu Gln Leu Ala Gln Phe Lys Met Pro Trp Thr Ser Pro Ser Cys 
65                  70                  75                  80  


Gln Asn Ser Cys Glu Leu Gly Ile Gln Asn Leu Ser Phe Lys Val Arg 
                85                  90                  95      


Ser Gly Gln Met Leu Ala Ile Ile Gly Ser Ser Gly Cys Gly Arg Ala 
            100                 105                 110         


Ser Leu Leu Asp Val Ile Thr Gly Arg Gly His Gly Gly Lys Ile Lys 
        115                 120                 125             


Ser Gly Gln Ile Trp Ile Asn Gly Gln Pro Ser Ser Pro Gln Leu Val 
    130                 135                 140                 


Arg Lys Cys Val Ala His Val Arg Gln His Asn Gln Leu Leu Pro Asn 
145                 150                 155                 160 


Leu Thr Val Arg Glu Thr Leu Ala Phe Ile Ala Gln Met Arg Leu Pro 
                165                 170                 175     


Arg Thr Phe Ser Gln Ala Gln Arg Asp Lys Arg Val Glu Asp Val Ile 
            180                 185                 190         


Ala Glu Leu Arg Leu Arg Gln Cys Ala Asp Thr Arg Val Gly Asn Met 
        195                 200                 205             


Tyr Val Arg Gly Leu Ser Gly Gly Glu Arg Arg Arg Val Ser Ile Gly 
    210                 215                 220                 


Val Gln Leu Leu Trp Asn Pro Gly Ile Leu Ile Leu Asp Glu Pro Thr 
225                 230                 235                 240 


Ser Gly Leu Asp Ser Phe Thr Ala His Asn Leu Val Lys Thr Leu Ser 
                245                 250                 255     


Arg Leu Ala Lys Gly Asn Arg Leu Val Leu Ile Ser Leu His Gln Pro 
            260                 265                 270         


Arg Ser Asp Ile Phe Arg Leu Phe Asp Leu Val Leu Leu Met Thr Ser 
        275                 280                 285             


Gly Thr Pro Ile Tyr Leu Gly Ala Ala Gln His Met Val Gln Tyr Phe 
    290                 295                 300                 


Thr Ala Ile Gly Tyr Pro Cys Pro Arg Tyr Ser Asn Pro Ala Asp Phe 
305                 310                 315                 320 


Tyr Val Asp Leu Thr Ser Ile Asp Arg Arg Ser Arg Glu Gln Glu Leu 
                325                 330                 335     


Ala Thr Arg Glu Lys Ala Gln Ser Leu Ala Ala Leu Phe Leu Glu Lys 
            340                 345                 350         


Val Arg Asp Leu Asp Asp Phe Leu Trp Lys Ala Glu Thr Lys Asp Leu 
        355                 360                 365             


Asp Glu Asp Thr Cys Val Glu Ser Ser Val Thr Pro Leu Asp Thr Asn 
    370                 375                 380                 


Cys Leu Pro Ser Pro Thr Lys Met Pro Gly Ala Val Gln Gln Phe Thr 
385                 390                 395                 400 


Thr Leu Ile Arg Arg Gln Ile Ser Asn Asp Phe Arg Asp Leu Pro Thr 
                405                 410                 415     


Leu Leu Ile His Gly Ala Glu Ala Cys Leu Met Ser Met Thr Ile Gly 
            420                 425                 430         


Phe Leu Tyr Phe Gly His Gly Ser Ile Gln Leu Ser Phe Met Asp Thr 
        435                 440                 445             


Ala Ala Leu Leu Phe Met Ile Gly Ala Leu Ile Pro Phe Asn Val Ile 
    450                 455                 460                 


Leu Asp Val Ile Ser Lys Cys Tyr Ser Glu Arg Ala Met Leu Tyr Tyr 
465                 470                 475                 480 


Glu Leu Glu Asp Gly Leu Tyr Thr Thr Gly Pro Tyr Phe Phe Ala Lys 
                485                 490                 495     


Ile Leu Gly Glu Leu Pro Glu His Cys Ala Tyr Ile Ile Ile Tyr Gly 
            500                 505                 510         


Met Pro Thr Tyr Trp Leu Ala Asn Leu Arg Pro Gly Leu Gln Pro Phe 
        515                 520                 525             


Leu Leu His Phe Leu Leu Val Trp Leu Val Val Phe Cys Cys Arg Ile 
    530                 535                 540                 


Met Ala Leu Ala Ala Ala Ala Leu Leu Pro Thr Phe His Met Ala Ser 
545                 550                 555                 560 


Phe Phe Ser Asn Ala Leu Tyr Asn Ser Phe Tyr Leu Ala Gly Gly Phe 
                565                 570                 575     


Met Ile Asn Leu Ser Ser Leu Trp Thr Val Pro Ala Trp Ile Ser Lys 
            580                 585                 590         


Val Ser Phe Leu Arg Trp Cys Phe Glu Gly Leu Met Lys Ile Gln Phe 
        595                 600                 605             


Ser Arg Arg Thr Tyr Lys Met Pro Leu Gly Asn Leu Thr Ile Ala Val 
    610                 615                 620                 


Ser Gly Asp Lys Ile Leu Ser Val Met Glu Leu Asp Ser Tyr Pro Leu 
625                 630                 635                 640 


Tyr Ala Ile Tyr Leu Ile Val Ile Gly Leu Ser Gly Gly Phe Met Val 
                645                 650                 655     


Leu Tyr Tyr Val Ser Leu Arg Phe Ile Lys Gln Lys Pro Ser Gln Asp 
            660                 665                 670         


Trp 
    


<210>  4914
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  4914

Met Ala Pro Ala Ala Ala Thr Gly Gly Ser Thr Leu Pro Ser Gly Phe 
1               5                   10                  15      


Ser Val Phe Thr Thr Leu Pro Asp Leu Leu Phe Ile Phe Glu Phe Ile 
            20                  25                  30          


Phe Gly Gly Leu Val Trp Ile Leu Val Ala Ser Ser Leu Val Pro Trp 
        35                  40                  45              


Pro Leu Val Gln Gly Trp Val Met Phe Val Ser Val Phe Cys Phe Val 
    50                  55                  60                  


Ala Thr Thr Thr Leu Ile Ile Leu Tyr Ile Ile Gly Ala His Gly Gly 
65                  70                  75                  80  


Glu Thr Ser Trp Val Thr Leu Val Phe Ser Tyr Ile Ala Thr Leu Leu 
                85                  90                  95      


Tyr Val Val His Ala Val Phe Ser Leu Ile Arg Trp Lys Ser Ser 
            100                 105                 110     


<210>  4915
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  4915

Met Ala Pro Ala Ala Ala Thr Gly Gly Ser Thr Leu Pro Ser Gly Phe 
1               5                   10                  15      


Ser Val Phe Thr Thr Leu Pro Asp Leu Leu Phe Ile Phe Glu Phe Asp 
            20                  25                  30          


Ala Ala Tyr His Cys Thr Ala Ala Leu Phe Tyr Leu Ser Ala Ser Val 
        35                  40                  45              


Leu Glu Ala Leu Ala Thr Ile Thr Met Gln Asp Gly Phe Thr Tyr Arg 
    50                  55                  60                  


His Tyr His Glu Asn Ile Ala Ala Val Val Phe Ser Tyr Ile Ala Thr 
65                  70                  75                  80  


Leu Leu Tyr Val Val His Ala Val Phe Ser Leu Ile Arg Trp Lys Ser 
                85                  90                  95      


Ser 
    


<210>  4916
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  4916

Met Ala Pro Ala Ala Ala Thr Gly Gly Ser Thr Leu Pro Ser Gly Phe 
1               5                   10                  15      


Ser Val Phe Thr Thr Leu Pro Asp Leu Leu Phe Ile Phe Glu Phe Val 
            20                  25                  30          


Phe Ser Tyr Ile Ala Thr Leu Leu Tyr Val Val His Ala Val Phe Ser 
        35                  40                  45              


Leu Ile Arg Trp Lys Ser Ser 
    50                  55  


<210>  4917
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  4917

Met Lys Glu Asp Leu Asn Leu Glu Asn Phe Thr Ala Lys Thr Ile Tyr 
1               5                   10                  15      


Glu Asn Arg Ile Tyr Ser Leu Lys Ile Glu Cys Gly Pro Lys Tyr Pro 
            20                  25                  30          


Glu Ala Pro Pro Phe Val Arg Phe Val Thr Lys Ile Asn Met Asn Gly 
        35                  40                  45              


Val Asn Ser Ser Asn Gly Val Val Asp Pro Arg Ala Ile Ser Val Leu 
    50                  55                  60                  


Ala Lys Trp Gln Asn Ser Tyr Ser Ile Lys Val Val Leu Gln Glu Leu 
65                  70                  75                  80  


Arg Arg Leu Met Met Ser Lys Glu Asn Met Lys Leu Pro Gln Pro Pro 
                85                  90                  95      


Glu Gly Gln Cys Tyr Ser Asn 
            100             


<210>  4918
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  4918

Met Lys Phe Phe Ser Tyr Ile Leu Val Tyr Arg Arg Phe Leu Phe Val 
1               5                   10                  15      


Val Phe Thr Val Leu Val Leu Leu Pro Leu Pro Ile Val Leu His Thr 
            20                  25                  30          


Lys Glu Ala Glu Cys Ala Tyr Thr Leu Phe Val Val Ala Thr Phe Trp 
        35                  40                  45              


Leu Thr Glu Ala Leu Pro Leu Ser Val Thr Ala Leu Leu Pro Ser Leu 
    50                  55                  60                  


Met Leu Pro Met Phe Gly Ile Met Pro Ser Lys Lys Val Ala Ser Ala 
65                  70                  75                  80  


Tyr Phe Lys Asp Phe His Leu Leu Leu Ile Gly Val Ile Cys Leu Ala 
                85                  90                  95      


Thr Ser Ile Glu Lys Trp Asn Leu His Lys Arg Ile Ala Leu Lys Met 
            100                 105                 110         


Val Met Met Val Gly Val Asn Pro Ala Trp Leu Thr Leu Gly Phe Met 
        115                 120                 125             


Ser Ser Thr Ala Phe Leu Ser Met Trp Leu Ser Asn Thr Ser Thr Ala 
    130                 135                 140                 


Ala Met Val Met Pro Ile Ala Glu Ala Val Val Gln Gln Ile Ile Asn 
145                 150                 155                 160 


Ala Glu Ala Glu Val Glu Ala Thr Gln Met Thr Tyr Phe Asn Gly Ser 
                165                 170                 175     


Thr Asn His Gly Leu Glu Ile Asp Glu Ser Val Asn Gly His Glu Ile 
            180                 185                 190         


Asn Glu Arg Lys Glu Lys Thr Lys Pro Val Pro Gly Tyr Asn Asn Asp 
        195                 200                 205             


Thr Gly Lys Ile Ser Ser Lys Val Glu Leu Glu Lys Asn Ser Gly Met 
    210                 215                 220                 


Arg Thr Lys Tyr Arg Thr Lys Lys Gly His Val Thr Arg Lys Leu Thr 
225                 230                 235                 240 


Cys Leu Cys Ile Ala Tyr Ser Ser Thr Ile Gly Gly Leu Thr Thr Ile 
                245                 250                 255     


Thr Gly Thr Ser Thr Asn Leu Ile Phe Ala Glu Tyr Phe Asn Thr Arg 
            260                 265                 270         


Tyr Pro Asp Cys Arg Cys Leu Asn Phe Gly Ser Trp Phe Thr Phe Ser 
        275                 280                 285             


Phe Pro Ala Ala Leu Ile Ile Leu Leu Leu Ser Trp Ile Trp Leu Gln 
    290                 295                 300                 


Trp Leu Phe Leu Gly Phe Asn Phe Lys Glu Met Phe Lys Cys Gly Lys 
305                 310                 315                 320 


Thr Lys Thr Val Gln Gln Lys Ala Cys Ala Glu Val Ile Lys Gln Glu 
                325                 330                 335     


Tyr Gln Lys Leu Gly Pro Ile Arg Tyr Gln Glu Ile Val Thr Leu Val 
            340                 345                 350         


Leu Phe Ile Ile Met Ala Leu Leu Trp Phe Ser Arg Asp Pro Gly Phe 
        355                 360                 365             


Val Pro Gly Trp Ser Ala Leu Phe Ser Glu Tyr Pro Gly Phe Ala Thr 
    370                 375                 380                 


Asp Ser Thr Val Ala Leu Leu Ile Gly Leu Leu Phe Phe Leu Ile Pro 
385                 390                 395                 400 


Ala Lys Thr Leu Thr Lys Thr Thr Pro Thr Gly Glu Ile Val Ala Phe 
                405                 410                 415     


Asp Tyr Ser Pro Leu Ile Thr Trp Lys Glu Phe Gln Ser Phe Met Pro 
            420                 425                 430         


Trp Asp Ile Ala Ile Leu Val Gly Gly Gly Phe Ala Leu Ala Asp Gly 
        435                 440                 445             


Cys Glu Glu Ser Gly Leu Ser Lys Trp Ile Gly Asn Lys Leu Ser Pro 
    450                 455                 460                 


Leu Gly Ser Leu Pro Ala Trp Leu Ile Ile Leu Ile Ser Ser Leu Met 
465                 470                 475                 480 


Val Thr Ser Leu Thr Glu Val Ala Ser Asn Pro Ala Thr Ile Thr Leu 
                485                 490                 495     


Phe Leu Pro Ile Leu Ser Pro Leu Ala Glu Ala Ile His Val Asn Pro 
            500                 505                 510         


Leu Tyr Ile Leu Ile Pro Ser Thr Leu Cys Thr Ser Phe Ala Phe Leu 
        515                 520                 525             


Leu Pro Val Ala Asn Pro Pro Asn Ala Ile Val Phe Ser Tyr Gly His 
    530                 535                 540                 


Leu Lys Val Ile Asp Met Val Lys Ala Gly Leu Gly Val Asn Ile Val 
545                 550                 555                 560 


Gly Val Ala Val Val Met Leu Gly Ile Cys Thr Trp Ile Val Pro Met 
                565                 570                 575     


Phe Asp Leu Tyr Thr Tyr Pro Ser Trp Ala Pro Ala Met Ser Asn Glu 
            580                 585                 590         


Thr Met Pro 
        595 


<210>  4919
<211>  855
<212>  PRT
<213>  Homo sapiens

<400>  4919

Met Ser Glu Ala Arg Arg Asp Ser Thr Ser Ser Leu Gln Arg Lys Lys 
1               5                   10                  15      


Pro Pro Trp Leu Lys Leu Asp Ile Pro Ser Ala Val Pro Leu Thr Ala 
            20                  25                  30          


Glu Glu Pro Ser Phe Leu Gln Pro Leu Arg Arg Gln Ala Phe Leu Arg 
        35                  40                  45              


Ser Val Ser Met Pro Ala Glu Thr Ala His Ile Ser Ser Pro His His 
    50                  55                  60                  


Glu Leu Arg Arg Pro Val Leu Gln Arg Gln Thr Ser Ile Thr Gln Thr 
65                  70                  75                  80  


Ile Arg Arg Gly Thr Ala Asp Trp Phe Gly Val Ser Lys Asp Ser Asp 
                85                  90                  95      


Ser Thr Gln Lys Trp Gln Arg Lys Ser Ile Arg His Cys Ser Gln Arg 
            100                 105                 110         


Tyr Gly Lys Leu Lys Pro Gln Val Leu Arg Glu Leu Asp Leu Pro Ser 
        115                 120                 125             


Gln Asp Asn Val Ser Leu Thr Ser Thr Glu Thr Pro Pro Pro Leu Tyr 
    130                 135                 140                 


Val Gly Pro Cys Gln Leu Gly Met Gln Lys Ile Ile Asp Pro Leu Ala 
145                 150                 155                 160 


Arg Gly Arg Ala Phe Arg Val Ala Asp Asp Thr Ala Glu Gly Leu Ser 
                165                 170                 175     


Ala Pro His Thr Pro Val Thr Pro Gly Ala Ala Ser Leu Cys Ser Phe 
            180                 185                 190         


Ser Ser Ser Arg Ser Gly Phe His Arg Leu Pro Arg Arg Arg Lys Arg 
        195                 200                 205             


Glu Ser Val Ala Lys Met Ser Phe Arg Ala Ala Ala Ala Leu Met Lys 
    210                 215                 220                 


Gly Arg Ser Val Arg Asp Gly Thr Phe Arg Arg Ala Gln Arg Arg Ser 
225                 230                 235                 240 


Phe Thr Pro Ala Ser Phe Leu Glu Glu Asp Thr Thr Asp Phe Pro Asp 
                245                 250                 255     


Glu Leu Asp Thr Ser Phe Phe Ala Arg Glu Gly Ile Leu His Glu Glu 
            260                 265                 270         


Leu Ser Thr Tyr Pro Asp Glu Val Phe Glu Ser Pro Ser Glu Ala Ala 
        275                 280                 285             


Leu Lys Asp Trp Glu Lys Ala Pro Glu Gln Ala Asp Leu Thr Gly Gly 
    290                 295                 300                 


Ala Leu Asp Arg Ser Glu Leu Glu Arg Ser His Leu Met Leu Pro Leu 
305                 310                 315                 320 


Glu Arg Gly Trp Arg Lys Gln Lys Glu Gly Ala Ala Ala Pro Gln Pro 
                325                 330                 335     


Lys Val Arg Leu Arg Gln Glu Val Val Ser Thr Ala Gly Pro Arg Arg 
            340                 345                 350         


Gly Gln Arg Ile Ala Val Pro Val Arg Lys Leu Phe Ala Arg Glu Lys 
        355                 360                 365             


Arg Pro Tyr Gly Leu Gly Met Val Gly Arg Leu Thr Asn Arg Thr Tyr 
    370                 375                 380                 


Arg Lys Arg Ile Asp Ser Phe Val Lys Arg Gln Ile Glu Asp Met Asp 
385                 390                 395                 400 


Asp His Arg Pro Phe Phe Thr Tyr Trp Leu Thr Phe Val His Ser Leu 
                405                 410                 415     


Val Thr Ile Leu Ala Val Cys Ile Tyr Gly Ile Ala Pro Val Gly Phe 
            420                 425                 430         


Ser Gln His Glu Thr Val Asp Ser Val Leu Arg Asn Arg Gly Val Tyr 
        435                 440                 445             


Glu Asn Val Lys Tyr Val Gln Gln Glu Asn Phe Trp Ile Gly Pro Ser 
    450                 455                 460                 


Ser Glu Ala Leu Ile His Leu Gly Ala Lys Phe Ser Pro Cys Met Arg 
465                 470                 475                 480 


Gln Asp Pro Gln Val His Ser Phe Ile Arg Ser Ala Arg Glu Arg Glu 
                485                 490                 495     


Lys His Ser Ala Cys Cys Val Arg Asn Asp Arg Ser Gly Cys Val Gln 
            500                 505                 510         


Thr Ser Glu Glu Glu Cys Ser Ser Thr Leu Ala Val Trp Val Lys Trp 
        515                 520                 525             


Pro Ile His Pro Ser Ala Pro Glu Leu Ala Gly His Lys Arg Gln Phe 
    530                 535                 540                 


Gly Ser Val Cys His Gln Asp Pro Arg Val Cys Asp Glu Pro Ser Ser 
545                 550                 555                 560 


Glu Asp Pro His Glu Trp Pro Glu Asp Ile Thr Lys Trp Pro Ile Cys 
                565                 570                 575     


Thr Lys Asn Ser Ala Gly Asn His Thr Asn His Pro His Met Asp Cys 
            580                 585                 590         


Val Ile Thr Gly Arg Pro Cys Cys Ile Gly Thr Lys Gly Arg Cys Glu 
        595                 600                 605             


Ile Thr Ser Arg Glu Tyr Cys Asp Phe Met Arg Gly Tyr Phe His Glu 
    610                 615                 620                 


Glu Ala Thr Leu Cys Ser Gln Val His Cys Met Asp Asp Val Cys Gly 
625                 630                 635                 640 


Leu Leu Pro Phe Leu Asn Pro Glu Val Pro Asp Gln Phe Tyr Arg Leu 
                645                 650                 655     


Trp Leu Ser Leu Phe Leu His Ala Gly Ile Leu His Cys Leu Val Ser 
            660                 665                 670         


Ile Cys Phe Gln Met Thr Val Leu Arg Asp Leu Glu Lys Leu Ala Gly 
        675                 680                 685             


Trp His Arg Ile Ala Ile Ile Tyr Leu Leu Ser Gly Val Thr Gly Asn 
    690                 695                 700                 


Leu Ala Ser Ala Ile Phe Leu Pro Tyr Arg Ala Glu Val Gly Pro Ala 
705                 710                 715                 720 


Gly Ser Gln Phe Gly Ile Leu Ala Cys Leu Phe Val Glu Leu Phe Gln 
                725                 730                 735     


Ser Trp Gln Ile Leu Ala Arg Pro Trp Arg Ala Phe Phe Lys Leu Leu 
            740                 745                 750         


Ala Val Val Leu Phe Leu Phe Thr Phe Gly Leu Leu Pro Trp Ile Asp 
        755                 760                 765             


Asn Phe Ala His Ile Ser Gly Phe Ile Ser Gly Leu Phe Leu Ser Phe 
    770                 775                 780                 


Ala Phe Leu Pro Tyr Ile Ser Phe Gly Lys Phe Asp Leu Tyr Arg Lys 
785                 790                 795                 800 


Arg Cys Gln Ile Ile Ile Phe Gln Val Val Phe Leu Gly Leu Leu Ala 
                805                 810                 815     


Gly Leu Val Val Leu Phe Tyr Val Tyr Pro Val Arg Cys Glu Trp Cys 
            820                 825                 830         


Glu Phe Leu Thr Cys Ile Pro Phe Thr Asp Lys Phe Cys Glu Lys Tyr 
        835                 840                 845             


Glu Leu Asp Ala Gln Leu His 
    850                 855 


<210>  4920
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  4920

Met Glu Gly Gln Asp Glu Val Ser Ala Arg Glu Gln His Phe His Ser 
1               5                   10                  15      


Gln Val Arg Glu Ser Thr Ile Cys Phe Leu Leu Phe Ala Ile Leu Tyr 
            20                  25                  30          


Val Val Ser Tyr Phe Ile Ile Thr Arg Tyr Lys Arg Lys Ser Asp Glu 
        35                  40                  45              


Gln Glu Asp Glu Asp Ala Ile Val Asn Arg Ile Ser Leu Phe Leu Ser 
    50                  55                  60                  


Thr Phe Thr Leu Ala Val Ser Ala Gly Ala Val Leu Leu Leu Pro Phe 
65                  70                  75                  80  


Ser Ile Ile Ser Asn Glu Ile Leu Leu Ser Phe Pro Gln Asn Tyr Tyr 
                85                  90                  95      


Ile Gln Trp Leu Asn Gly Ser Leu Ile His Gly Leu Trp Asn Leu Ala 
            100                 105                 110         


Ser Leu Phe Ser Asn Leu Cys Leu Phe Val Leu Met Pro Phe Ala Phe 
        115                 120                 125             


Phe Phe Leu Glu Ser Glu Gly Phe Ala Gly Leu Lys Lys Gly Ile Arg 
    130                 135                 140                 


Ala Arg Ile Leu Glu Thr Leu Val Met Leu Leu Leu Leu Ala Leu Leu 
145                 150                 155                 160 


Ile Leu Gly Ile Val Trp Val Ala Ser Ala Leu Ile Asp Asn Asp Ala 
                165                 170                 175     


Ala Ser Met Glu Ser Leu Tyr Asp Leu Trp Glu Phe Tyr Leu Pro Tyr 
            180                 185                 190         


Leu Tyr Ser Cys Ile Ser Leu Met Gly Cys Leu Leu Leu Leu Leu Cys 
        195                 200                 205             


Thr Pro Val Gly Leu Ser Arg Met Phe Thr Val Met Gly Gln Leu Leu 
    210                 215                 220                 


Val Lys Pro Thr Ile Leu Glu Asp Leu Asp Glu Gln Ile Tyr Ile Ile 
225                 230                 235                 240 


Thr Leu Glu Glu Glu Ala Leu Gln Arg Arg Leu Asn Gly Leu Ser Ser 
                245                 250                 255     


Ser Val Glu Tyr Asn Ile Met Glu Leu Glu Gln Glu Leu Glu Asn Val 
            260                 265                 270         


Lys Thr Leu Lys Thr Lys Leu Glu Arg Arg Lys Lys Ala Ser Ala Trp 
        275                 280                 285             


Glu Arg Asn Leu Val Tyr Pro Ala Val Met Val Leu Leu Leu Ile Glu 
    290                 295                 300                 


Thr Ser Ile Ser Val Leu Leu Val Ala Cys Asn Ile Leu Cys Leu Leu 
305                 310                 315                 320 


Val Asp Glu Thr Ala Met Pro Lys Gly Thr Arg Gly Pro Gly Ile Gly 
                325                 330                 335     


Asn Ala Ser Leu Ser Thr Phe Gly Phe Val Gly Ala Ala Leu Glu Ile 
            340                 345                 350         


Ile Leu Ile Phe Tyr Leu Met Val Ser Ser Val Val Gly Phe Tyr Ser 
        355                 360                 365             


Leu Arg Phe Phe Gly Asn Phe Thr Pro Lys Lys Asp Asp Thr Thr Met 
    370                 375                 380                 


Thr Lys Ile Ile Gly Asn Cys Val Ser Ile Leu Val Leu Ser Ser Ala 
385                 390                 395                 400 


Leu Pro Val Met Ser Arg Thr Leu Gly Ile Thr Arg Phe Asp Leu Leu 
                405                 410                 415     


Gly Asp Phe Gly Arg Phe Asn Trp Leu Gly Asn Phe Tyr Ile Val Leu 
            420                 425                 430         


Ser Tyr Asn Leu Leu Phe Ala Ile Val Thr Thr Leu Cys Leu Val Arg 
        435                 440                 445             


Lys Phe Thr Ser Ala Val Arg Glu Glu Leu Phe Lys Ala Leu Gly Leu 
    450                 455                 460                 


His Lys Leu His Leu Pro Asn Thr Ser Arg Asp Ser Glu Thr Ala Lys 
465                 470                 475                 480 


Pro Ser Val Asn Gly His Gln Lys Ala Leu 
                485                 490 


<210>  4921
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  4921

Met Thr Leu Arg Pro Gly Thr Met Arg Leu Ala Cys Met Phe Ser Ser 
1               5                   10                  15      


Ile Leu Leu Phe Gly Ala Ala Gly Leu Leu Leu Phe Ile Ser Leu Gln 
            20                  25                  30          


Asp Pro Thr Glu Leu Ala Pro Gln Gln Val Pro Gly Ile Lys Phe Asn 
        35                  40                  45              


Ile Arg Pro Arg Gln Pro His His Asp Leu Pro Pro Gly Gly Ser Gln 
    50                  55                  60                  


Asp Gly Asp Leu Lys Glu Pro Thr Glu Arg Val Thr Arg Asp Leu Ser 
65                  70                  75                  80  


Ser Gly Ala Pro Arg Gly Arg Asn Leu Pro Ala Pro Asp Gln Pro Gln 
                85                  90                  95      


Pro Pro Leu Gln Arg Gly Thr Arg Leu Arg Leu Arg Gln Arg Arg Arg 
            100                 105                 110         


Arg Leu Leu Ile Lys Lys Met Pro Ala Ala Ala Thr Ile Pro Ala Asn 
        115                 120                 125             


Ser Ser Asp Ala Pro Phe Ile Arg Pro Gly Pro Gly Thr Leu Asp Gly 
    130                 135                 140                 


Arg Trp Val Ser Leu His Arg Ser Gln Gln Glu Arg Lys Arg Val Met 
145                 150                 155                 160 


Gln Glu Ala Cys Ala Lys Tyr Arg Ala Ser Ser Ser Arg Arg Ala Val 
                165                 170                 175     


Thr Pro Arg His Val Ser Arg Ile Phe Val Glu Asp Arg His Arg Val 
            180                 185                 190         


Leu Tyr Cys Glu Val Pro Lys Ala Gly Cys Ser Asn Trp Lys Arg Val 
        195                 200                 205             


Leu Met Val Leu Ala Gly Leu Ala Ser Ser Thr Ala Asp Ile Gln His 
    210                 215                 220                 


Asn Thr Val His Tyr Gly Ser Ala Leu Lys Arg Leu Asp Thr Phe Asp 
225                 230                 235                 240 


Arg Gln Gly Ile Leu His Arg Leu Ser Thr Tyr Thr Lys Met Leu Phe 
                245                 250                 255     


Val Arg Glu Pro Phe Glu Arg Leu Val Ser Ala Phe Arg Asp Lys Phe 
            260                 265                 270         


Glu His Pro Asn Ser Tyr Tyr His Pro Val Phe Gly Lys Ala Ile Leu 
        275                 280                 285             


Ala Arg Tyr Arg Ala Asn Ala Ser Arg Glu Ala Leu Arg Thr Gly Ser 
    290                 295                 300                 


Gly Val Arg Phe Pro Glu Phe Val Gln Tyr Leu Leu Asp Val His Arg 
305                 310                 315                 320 


Pro Val Gly Met Asp Ile His Trp Asp His Val Ser Arg Leu Cys Ser 
                325                 330                 335     


Pro Cys Leu Ile Asp Tyr Asp Phe Val Gly Lys Phe Glu Ser Met Glu 
            340                 345                 350         


Asp Asp Ala Asn Phe Phe Leu Ser Leu Ile Arg Ala Pro Arg Asn Leu 
        355                 360                 365             


Thr Phe Pro Arg Phe Lys Asp Arg His Ser Gln Glu Ala Arg Thr Thr 
    370                 375                 380                 


Ala Arg Ile Ala His Gln Tyr Phe Ala Gln Leu Ser Ala Leu Gln Arg 
385                 390                 395                 400 


Gln Arg Thr Tyr Asp Phe Tyr Tyr Met Asp Tyr Leu Met Phe Asn Tyr 
                405                 410                 415     


Ser Lys Pro Phe Ala Asp Leu Tyr 
            420                 


<210>  4922
<211>  819
<212>  PRT
<213>  Homo sapiens

<400>  4922

Met Trp Gly Leu Val Arg Leu Leu Leu Ala Trp Leu Gly Gly Trp Gly 
1               5                   10                  15      


Cys Met Gly Arg Leu Ala Ala Pro Ala Arg Ala Trp Ala Gly Ser Arg 
            20                  25                  30          


Glu His Pro Gly Pro Ala Leu Leu Arg Thr Arg Arg Ser Trp Val Trp 
        35                  40                  45              


Asn Gln Phe Phe Val Ile Glu Glu Tyr Ala Gly Pro Glu Pro Val Leu 
    50                  55                  60                  


Ile Gly Lys Leu His Ser Asp Val Asp Arg Gly Glu Gly Arg Thr Lys 
65                  70                  75                  80  


Tyr Leu Leu Thr Gly Glu Gly Ala Gly Thr Val Phe Val Ile Asp Glu 
                85                  90                  95      


Ala Thr Gly Asn Ile His Val Thr Lys Ser Leu Asp Arg Glu Glu Lys 
            100                 105                 110         


Ala Gln Tyr Val Leu Leu Ala Gln Ala Val Asp Arg Ala Ser Asn Arg 
        115                 120                 125             


Pro Leu Glu Pro Pro Ser Glu Phe Ile Ile Lys Val Gln Asp Ile Asn 
    130                 135                 140                 


Asp Asn Pro Pro Ile Phe Pro Leu Gly Pro Tyr His Ala Thr Val Pro 
145                 150                 155                 160 


Glu Met Ser Asn Val Gly Thr Ser Val Ile Gln Val Thr Ala His Asp 
                165                 170                 175     


Ala Asp Asp Pro Ser Tyr Gly Asn Ser Ala Lys Leu Val Tyr Thr Val 
            180                 185                 190         


Leu Asp Gly Leu Pro Phe Phe Ser Val Asp Pro Gln Thr Gly Val Val 
        195                 200                 205             


Arg Thr Ala Ile Pro Asn Met Asp Arg Glu Thr Gln Glu Glu Phe Leu 
    210                 215                 220                 


Val Val Ile Gln Ala Lys Asp Met Gly Gly His Met Gly Gly Leu Ser 
225                 230                 235                 240 


Gly Ser Thr Thr Val Thr Val Thr Leu Ser Asp Val Asn Asp Asn Pro 
                245                 250                 255     


Pro Lys Phe Pro Gln Ser Leu Tyr Gln Phe Ser Val Val Glu Thr Ala 
            260                 265                 270         


Gly Pro Gly Thr Leu Val Gly Arg Leu Arg Ala Gln Asp Pro Asp Leu 
        275                 280                 285             


Gly Asp Asn Ala Leu Met Ala Tyr Ser Ile Leu Asp Gly Glu Gly Ser 
    290                 295                 300                 


Glu Ala Phe Ser Ile Ser Thr Asp Leu Gln Gly Arg Asp Gly Leu Leu 
305                 310                 315                 320 


Thr Val Arg Lys Pro Leu Asp Phe Glu Ser Gln Arg Ser Tyr Ser Phe 
                325                 330                 335     


Arg Val Glu Ala Thr Asn Thr Leu Ile Asp Pro Ala Tyr Leu Arg Arg 
            340                 345                 350         


Gly Pro Phe Lys Asp Val Ala Ser Val Arg Val Ala Val Gln Asp Ala 
        355                 360                 365             


Pro Glu Pro Pro Ala Phe Thr Gln Ala Ala Tyr His Leu Thr Val Pro 
    370                 375                 380                 


Glu Asn Lys Ala Pro Gly Thr Leu Val Gly Gln Ile Ser Ala Ala Asp 
385                 390                 395                 400 


Leu Asp Ser Pro Ala Ser Pro Ile Arg Tyr Ser Ile Leu Pro His Ser 
                405                 410                 415     


Asp Pro Glu Arg Cys Phe Ser Ile Gln Pro Glu Glu Gly Thr Ile His 
            420                 425                 430         


Thr Ala Ala Pro Leu Asp Arg Glu Ala Arg Ala Trp His Asn Leu Thr 
        435                 440                 445             


Val Leu Ala Thr Glu Leu Gly Trp Ser Trp Gly Pro Glu Arg Gly Trp 
    450                 455                 460                 


Val Pro Leu Leu Val Ala Glu Trp Ser Ala Pro Ala Ala Pro Pro Gln 
465                 470                 475                 480 


Arg Ser Pro Val Gly Ser Ala Val Gly Ile Pro Gln Asp Ser Ser Ala 
                485                 490                 495     


Gln Ala Ser Arg Val Gln Val Ala Ile Gln Thr Leu Asp Glu Asn Asp 
            500                 505                 510         


Asn Ala Pro Gln Leu Ala Glu Pro Tyr Asp Thr Phe Val Cys Asp Ser 
        515                 520                 525             


Ala Ala Pro Gly Gln Leu Ile Gln Val Ile Arg Ala Leu Asp Arg Asp 
    530                 535                 540                 


Glu Val Gly Asn Ser Ser His Val Ser Phe Gln Gly Pro Leu Gly Pro 
545                 550                 555                 560 


Asp Ala Asn Phe Thr Val Gln Asp Asn Arg Asp Gly Ser Ala Ser Leu 
                565                 570                 575     


Leu Leu Pro Ser Arg Pro Ala Pro Pro Arg His Ala Pro Tyr Leu Val 
            580                 585                 590         


Pro Ile Glu Leu Trp Asp Trp Gly Gln Pro Ala Leu Ser Ser Thr Ala 
        595                 600                 605             


Thr Val Thr Val Ser Val Cys Arg Cys Gln Pro Asp Gly Ser Val Ala 
    610                 615                 620                 


Ser Cys Trp Pro Glu Ala His Leu Ser Ala Ala Gly Leu Ser Thr Gly 
625                 630                 635                 640 


Ala Leu Leu Ala Ile Ile Thr Cys Val Gly Ala Leu Leu Ala Leu Val 
                645                 650                 655     


Val Leu Phe Val Ala Leu Arg Arg Gln Lys Gln Glu Ala Leu Met Val 
            660                 665                 670         


Leu Glu Glu Glu Asp Val Arg Glu Asn Ile Ile Thr Tyr Asp Asp Glu 
        675                 680                 685             


Gly Gly Gly Glu Glu Asp Thr Glu Ala Phe Asp Ile Thr Ala Leu Gln 
    690                 695                 700                 


Asn Pro Asp Gly Ala Ala Pro Pro Ala Pro Gly Pro Pro Ala Arg Arg 
705                 710                 715                 720 


Asp Val Leu Pro Arg Ala Arg Val Ser Arg Gln Pro Arg Pro Pro Gly 
                725                 730                 735     


Pro Ala Asp Val Ala Gln Leu Leu Ala Leu Arg Leu Arg Glu Ala Asp 
            740                 745                 750         


Glu Asp Pro Gly Val Pro Pro Tyr Asp Ser Val Gln Val Tyr Gly Tyr 
        755                 760                 765             


Glu Gly Arg Gly Ser Ser Cys Gly Ser Leu Ser Ser Leu Gly Ser Gly 
    770                 775                 780                 


Ser Glu Ala Gly Gly Ala Pro Gly Pro Ala Glu Pro Leu Asp Asp Trp 
785                 790                 795                 800 


Gly Pro Leu Phe Arg Thr Leu Ala Glu Leu Tyr Gly Ala Lys Glu Pro 
                805                 810                 815     


Pro Ala Pro 
            


<210>  4923
<211>  598
<212>  PRT
<213>  Homo sapiens

<400>  4923

Met Ala Ser Leu Arg Arg Val Lys Val Leu Leu Val Leu Asn Leu Ile 
1               5                   10                  15      


Ala Val Ala Gly Phe Val Leu Phe Leu Ala Lys Cys Arg Pro Ile Ala 
            20                  25                  30          


Val Arg Ser Gly Asp Ala Phe His Glu Ile Arg Pro Arg Ala Glu Val 
        35                  40                  45              


Ala Asn Leu Ser Ala His Ser Ala Ser Pro Ile Gln Asp Ala Val Leu 
    50                  55                  60                  


Lys Arg Leu Ser Leu Leu Glu Asp Ile Val Tyr Arg Gln Leu Asn Gly 
65                  70                  75                  80  


Leu Ser Lys Ser Leu Gly Leu Ile Glu Gly Tyr Gly Gly Arg Gly Lys 
                85                  90                  95      


Gly Gly Leu Pro Ala Thr Leu Ser Pro Ala Glu Glu Glu Lys Ala Lys 
            100                 105                 110         


Gly Pro His Glu Lys Tyr Gly Tyr Asn Ser Tyr Leu Ser Glu Lys Ile 
        115                 120                 125             


Ser Leu Asp Arg Ser Ile Pro Asp Tyr Arg Pro Thr Lys Cys Lys Glu 
    130                 135                 140                 


Leu Lys Tyr Ser Lys Asp Leu Pro Gln Ile Ser Ile Ile Phe Ile Phe 
145                 150                 155                 160 


Val Asn Glu Ala Leu Ser Val Ile Leu Arg Ser Val His Ser Ala Val 
                165                 170                 175     


Asn His Thr Pro Thr His Leu Leu Lys Glu Ile Ile Leu Val Asp Asp 
            180                 185                 190         


Asn Ser Asp Glu Glu Glu Leu Lys Val Pro Leu Glu Glu Tyr Val His 
        195                 200                 205             


Lys Arg Tyr Pro Gly Leu Val Lys Val Val Arg Asn Gln Lys Arg Glu 
    210                 215                 220                 


Gly Leu Ile Arg Ala Arg Ile Glu Gly Trp Lys Val Ala Thr Gly Gln 
225                 230                 235                 240 


Val Thr Gly Phe Phe Asp Ala His Val Glu Phe Thr Ala Gly Trp Ala 
                245                 250                 255     


Glu Pro Val Leu Ser Arg Ile Gln Glu Asn Arg Lys Arg Val Ile Leu 
            260                 265                 270         


Pro Ser Ile Asp Asn Ile Lys Gln Asp Asn Phe Glu Val Gln Arg Tyr 
        275                 280                 285             


Glu Asn Ser Ala His Gly Tyr Ser Trp Glu Leu Trp Cys Met Tyr Ile 
    290                 295                 300                 


Ser Pro Pro Lys Asp Trp Trp Asp Ala Gly Asp Pro Ser Leu Pro Ile 
305                 310                 315                 320 


Arg Thr Pro Ala Met Ile Gly Cys Ser Phe Val Val Asn Arg Lys Phe 
                325                 330                 335     


Phe Gly Glu Ile Gly Leu Leu Asp Pro Gly Met Asp Val Tyr Gly Gly 
            340                 345                 350         


Glu Asn Ile Glu Leu Gly Ile Lys Val Trp Leu Cys Gly Gly Ser Met 
        355                 360                 365             


Glu Val Leu Pro Cys Ser Arg Val Ala His Ile Glu Arg Lys Lys Lys 
    370                 375                 380                 


Pro Tyr Asn Ser Asn Ile Gly Phe Tyr Thr Lys Arg Asn Ala Leu Arg 
385                 390                 395                 400 


Val Ala Glu Val Trp Met Asp Asp Tyr Lys Ser His Val Tyr Ile Ala 
                405                 410                 415     


Trp Asn Leu Pro Leu Glu Asn Pro Gly Ile Asp Ile Gly Asp Val Ser 
            420                 425                 430         


Glu Arg Arg Ala Leu Arg Lys Ser Leu Lys Cys Lys Asn Phe Gln Trp 
        435                 440                 445             


Tyr Leu Asp His Val Tyr Pro Glu Met Arg Arg Tyr Asn Asn Thr Val 
    450                 455                 460                 


Ala Tyr Gly Glu Leu Arg Asn Asn Lys Ala Lys Asp Val Cys Leu Asp 
465                 470                 475                 480 


Gln Gly Pro Leu Glu Asn His Thr Ala Ile Leu Tyr Pro Cys His Gly 
                485                 490                 495     


Trp Gly Pro Gln Leu Ala Arg Tyr Thr Lys Glu Gly Phe Leu His Leu 
            500                 505                 510         


Gly Ala Leu Gly Thr Thr Thr Leu Leu Pro Asp Thr Arg Cys Leu Val 
        515                 520                 525             


Asp Asn Ser Lys Ser Arg Leu Pro Gln Leu Leu Asp Cys Asp Lys Val 
    530                 535                 540                 


Lys Ser Ser Leu Tyr Lys Arg Trp Asn Phe Ile Gln Asn Gly Ala Ile 
545                 550                 555                 560 


Met Asn Lys Gly Thr Gly Arg Cys Leu Glu Val Glu Asn Arg Gly Leu 
                565                 570                 575     


Ala Gly Ile Asp Leu Ile Leu Arg Ser Cys Thr Gly Gln Arg Trp Thr 
            580                 585                 590         


Ile Lys Asn Ser Ile Lys 
        595             


<210>  4924
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  4924

Met Ala Ser Glu Thr Glu Lys Thr His Ala Leu Leu Gln Thr Cys Ser 
1               5                   10                  15      


Thr Glu Ser Leu Ile Ser Ser Leu Gly Leu Gly Ala Phe Cys Leu Val 
            20                  25                  30          


Ala Asp Arg Leu Leu Gln Phe Ser Thr Ile Gln Gln Asn Asp Trp Leu 
        35                  40                  45              


Arg Ala Leu Ser Asp Asn Ala Val His Cys Val Ile Gly Met Trp Ser 
    50                  55                  60                  


Trp Ala Val Val Thr Gly Ile Lys Lys Lys Thr Asp Phe Gly Glu Ile 
65                  70                  75                  80  


Ile Leu Ala Gly Phe Leu Ala Ser Val Ile Asp Val Asp His Phe Phe 
                85                  90                  95      


Leu Ala Gly Ser Met Ser Leu Lys Ala Ala Leu Thr Leu Pro Arg Arg 
            100                 105                 110         


Pro Phe Leu His Cys Ser Thr Val Ile Pro Val Val Val Leu Thr Leu 
        115                 120                 125             


Lys Phe Thr Met His Leu Phe Lys Leu Lys Asp Ser Trp Cys Phe Leu 
    130                 135                 140                 


Pro Trp Met Leu Phe Ile Ser Trp Thr Ser His His Ile Arg Asp Gly 
145                 150                 155                 160 


Ile Arg His Gly Leu Trp Ile Cys Pro Phe Gly Lys Thr Ser Pro Leu 
                165                 170                 175     


Pro Phe Trp Leu Tyr Val Ile Ile Thr Ser Ser Leu Pro His Ile Cys 
            180                 185                 190         


Ser Phe Val Met Tyr Leu Thr Gly Thr Arg Gln Met Met Ser Ser Lys 
        195                 200                 205             


His Gly Val Arg Ile Asp Val 
    210                 215 


<210>  4925
<211>  697
<212>  PRT
<213>  Homo sapiens

<400>  4925

Met Cys Lys Ser Leu Arg Tyr Cys Phe Ser His Cys Leu Tyr Leu Ala 
1               5                   10                  15      


Met Thr Arg Leu Glu Glu Val Asn Arg Glu Val Asn Met His Ser Ser 
            20                  25                  30          


Val Arg Tyr Leu Gly Tyr Leu Ala Arg Ile Asn Leu Leu Val Ala Ile 
        35                  40                  45              


Cys Leu Gly Leu Tyr Val Arg Trp Glu Lys Thr Ala Asn Ser Leu Ile 
    50                  55                  60                  


Leu Val Ile Phe Ile Leu Gly Leu Phe Val Leu Gly Ile Ala Ser Ile 
65                  70                  75                  80  


Leu Tyr Tyr Tyr Phe Ser Met Glu Ala Ala Ser Leu Ser Leu Ser Asn 
                85                  90                  95      


Leu Trp Phe Gly Phe Leu Leu Gly Leu Leu Cys Phe Leu Asp Asn Ser 
            100                 105                 110         


Ser Phe Lys Asn Asp Val Lys Glu Glu Ser Thr Lys Tyr Leu Leu Leu 
        115                 120                 125             


Thr Ser Ile Val Leu Arg Ile Leu Cys Ser Leu Val Glu Arg Ile Ser 
    130                 135                 140                 


Gly Tyr Val Arg His Arg Pro Thr Leu Leu Thr Thr Val Glu Phe Leu 
145                 150                 155                 160 


Glu Leu Val Gly Phe Ala Ile Ala Ser Thr Thr Met Leu Val Glu Lys 
                165                 170                 175     


Ser Leu Ser Val Ile Leu Leu Val Val Ala Leu Ala Met Leu Ile Ile 
            180                 185                 190         


Asp Leu Arg Met Lys Ser Phe Leu Ala Ile Pro Asn Leu Val Ile Phe 
        195                 200                 205             


Ala Val Leu Leu Phe Phe Ser Ser Leu Glu Thr Pro Lys Asn Pro Ile 
    210                 215                 220                 


Ala Phe Ala Cys Phe Phe Ile Cys Leu Ile Thr Asp Pro Phe Leu Asp 
225                 230                 235                 240 


Ile Tyr Phe Ser Gly Leu Ser Val Thr Glu Arg Trp Lys Pro Phe Leu 
                245                 250                 255     


Tyr Arg Gly Arg Ile Cys Arg Arg Leu Ser Val Val Phe Ala Gly Met 
            260                 265                 270         


Ile Glu Leu Thr Phe Phe Ile Leu Ser Ala Phe Lys Leu Arg Asp Thr 
        275                 280                 285             


His Leu Trp Tyr Phe Val Ile Pro Gly Phe Ser Ile Phe Gly Ile Phe 
    290                 295                 300                 


Trp Met Ile Cys His Ile Ile Phe Leu Leu Thr Leu Trp Gly Phe His 
305                 310                 315                 320 


Thr Lys Leu Asn Asp Cys His Lys Val Tyr Phe Thr His Arg Thr Asp 
                325                 330                 335     


Tyr Asn Ser Leu Asp Arg Ile Met Ala Ser Lys Gly Met Arg His Phe 
            340                 345                 350         


Cys Leu Ile Ser Glu Gln Leu Val Phe Phe Ser Leu Leu Ala Thr Ala 
        355                 360                 365             


Ile Leu Gly Ala Val Ser Trp Gln Pro Thr Asn Gly Ile Phe Leu Ser 
    370                 375                 380                 


Met Phe Leu Ile Val Leu Pro Leu Glu Ser Met Ala His Gly Leu Phe 
385                 390                 395                 400 


His Glu Leu Gly Asn Cys Leu Gly Gly Thr Ser Val Gly Tyr Ala Ile 
                405                 410                 415     


Val Ile Pro Thr Asn Phe Cys Ser Pro Asp Gly Gln Pro Thr Leu Leu 
            420                 425                 430         


Pro Pro Glu His Val Gln Glu Leu Asn Leu Arg Ser Thr Gly Met Leu 
        435                 440                 445             


Asn Ala Ile Gln Arg Phe Phe Ala Tyr His Met Ile Glu Thr Tyr Gly 
    450                 455                 460                 


Cys Asp Tyr Ser Thr Ser Gly Leu Ser Phe Asp Thr Leu His Ser Lys 
465                 470                 475                 480 


Leu Lys Ala Phe Leu Glu Leu Arg Thr Val Asp Gly Pro Arg His Asp 
                485                 490                 495     


Thr Tyr Ile Leu Tyr Tyr Ser Gly His Thr His Gly Thr Gly Glu Trp 
            500                 505                 510         


Ala Leu Ala Gly Gly Asp Thr Leu Arg Leu Asp Thr Leu Ile Glu Trp 
        515                 520                 525             


Trp Arg Glu Lys Asn Gly Ser Phe Cys Ser Arg Leu Ile Ile Val Leu 
    530                 535                 540                 


Asp Ser Glu Asn Ser Thr Pro Trp Val Lys Glu Val Arg Lys Ile Asn 
545                 550                 555                 560 


Asp Gln Tyr Ile Ala Val Gln Gly Ala Glu Leu Ile Lys Thr Val Asp 
                565                 570                 575     


Ile Glu Glu Ala Asp Pro Pro Gln Leu Gly Asp Phe Thr Lys Asp Trp 
            580                 585                 590         


Val Glu Tyr Asn Cys Asn Ser Ser Asn Asn Ile Cys Trp Thr Glu Lys 
        595                 600                 605             


Gly Arg Thr Val Lys Ala Val Tyr Gly Val Ser Lys Arg Trp Ser Asp 
    610                 615                 620                 


Tyr Thr Leu His Leu Pro Thr Gly Ser Asp Val Ala Lys His Trp Met 
625                 630                 635                 640 


Leu His Phe Pro Arg Ile Thr Tyr Pro Leu Val His Leu Ala Asn Trp 
                645                 650                 655     


Leu Cys Gly Leu Asn Leu Phe Trp Ile Cys Lys Thr Cys Phe Arg Cys 
            660                 665                 670         


Leu Lys Arg Leu Lys Met Ser Trp Phe Leu Pro Thr Val Leu Asp Thr 
        675                 680                 685             


Gly Gln Gly Phe Lys Leu Val Lys Ser 
    690                 695         


<210>  4926
<211>  747
<212>  PRT
<213>  Homo sapiens

<400>  4926

Met Gly Arg Gly Pro Trp Asp Ala Gly Pro Ser Arg Arg Leu Leu Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Gly Leu Ala Arg Gly Ala Ala Gly Ala Pro Gly 
            20                  25                  30          


Pro Asp Gly Leu Asp Val Cys Ala Thr Cys His Glu His Ala Thr Cys 
        35                  40                  45              


Gln Gln Arg Glu Gly Lys Lys Ile Cys Ile Cys Asn Tyr Gly Phe Val 
    50                  55                  60                  


Gly Asn Gly Arg Thr Gln Cys Val Asp Lys Asn Glu Cys Gln Phe Gly 
65                  70                  75                  80  


Ala Thr Leu Val Cys Gly Asn His Thr Ser Cys His Asn Thr Pro Gly 
                85                  90                  95      


Gly Phe Tyr Cys Ile Cys Leu Glu Gly Tyr Arg Ala Thr Asn Asn Asn 
            100                 105                 110         


Lys Thr Phe Ile Pro Asn Asp Gly Thr Phe Cys Thr Asp Ile Asp Glu 
        115                 120                 125             


Cys Glu Val Ser Gly Leu Cys Arg His Gly Gly Arg Cys Val Asn Thr 
    130                 135                 140                 


His Gly Ser Phe Glu Cys Tyr Cys Met Asp Gly Tyr Leu Pro Arg Asn 
145                 150                 155                 160 


Gly Pro Glu Pro Phe His Pro Thr Thr Asp Ala Thr Ser Cys Thr Glu 
                165                 170                 175     


Ile Asp Cys Gly Thr Pro Pro Glu Val Pro Asp Gly Tyr Ile Ile Gly 
            180                 185                 190         


Asn Tyr Thr Ser Ser Leu Gly Ser Gln Val Arg Tyr Ala Cys Arg Glu 
        195                 200                 205             


Gly Phe Phe Ser Val Pro Glu Asp Thr Val Ser Ser Cys Thr Gly Leu 
    210                 215                 220                 


Gly Thr Trp Glu Ser Pro Lys Leu His Cys Gln Glu Ile Asn Cys Gly 
225                 230                 235                 240 


Asn Pro Pro Glu Met Arg His Ala Ile Leu Val Gly Asn His Ser Ser 
                245                 250                 255     


Arg Leu Gly Gly Val Ala Arg Tyr Val Cys Gln Glu Gly Phe Glu Ser 
            260                 265                 270         


Pro Gly Gly Lys Ile Thr Ser Val Cys Thr Glu Lys Gly Thr Trp Arg 
        275                 280                 285             


Glu Ser Thr Leu Thr Cys Thr Glu Ile Leu Thr Lys Ile Asn Asp Val 
    290                 295                 300                 


Ser Leu Phe Asn Asp Thr Cys Val Arg Trp Gln Ile Asn Ser Arg Arg 
305                 310                 315                 320 


Ile Asn Pro Lys Ile Ser Tyr Val Ile Ser Ile Lys Gly Gln Arg Leu 
                325                 330                 335     


Asp Pro Met Glu Ser Val Arg Glu Glu Thr Val Asn Leu Thr Thr Asp 
            340                 345                 350         


Ser Arg Thr Pro Glu Val Cys Leu Ala Leu Tyr Pro Gly Thr Asn Tyr 
        355                 360                 365             


Thr Val Asn Ile Ser Thr Ala Pro Pro Arg Arg Ser Met Pro Ala Val 
    370                 375                 380                 


Ile Gly Phe Gln Thr Ala Glu Val Asp Leu Leu Glu Asp Asp Gly Ser 
385                 390                 395                 400 


Phe Asn Ile Ser Ile Phe Asn Glu Thr Cys Leu Lys Leu Asn Arg Arg 
                405                 410                 415     


Ser Arg Lys Val Gly Ser Glu His Met Tyr Gln Phe Thr Val Leu Gly 
            420                 425                 430         


Gln Arg Trp Tyr Leu Ala Asn Phe Ser His Ala Thr Ser Phe Asn Phe 
        435                 440                 445             


Thr Thr Arg Glu Gln Val Pro Val Val Cys Leu Asp Leu Tyr Pro Thr 
    450                 455                 460                 


Thr Asp Tyr Thr Val Asn Val Thr Leu Leu Arg Ser Pro Lys Arg His 
465                 470                 475                 480 


Ser Val Gln Ile Thr Ile Ala Thr Pro Pro Ala Val Lys Gln Thr Ile 
                485                 490                 495     


Ser Asn Ile Ser Gly Phe Asn Glu Thr Cys Leu Arg Trp Arg Ser Ile 
            500                 505                 510         


Lys Thr Ala Asp Met Glu Glu Met Tyr Leu Phe His Ile Trp Gly Gln 
        515                 520                 525             


Arg Trp Tyr Gln Lys Glu Phe Ala Gln Glu Met Thr Phe Asn Ile Ser 
    530                 535                 540                 


Ser Ser Ser Arg Asp Pro Glu Val Cys Leu Asp Leu Arg Pro Gly Thr 
545                 550                 555                 560 


Asn Tyr Asn Val Ser Leu Arg Ala Leu Ser Ser Glu Leu Pro Val Val 
                565                 570                 575     


Ile Ser Leu Thr Thr Gln Ile Thr Glu Pro Pro Leu Pro Glu Val Glu 
            580                 585                 590         


Phe Phe Thr Val His Arg Gly Pro Leu Pro Arg Leu Arg Leu Arg Lys 
        595                 600                 605             


Ala Lys Glu Lys Asn Gly Pro Ile Ser Ser Tyr Gln Val Leu Val Leu 
    610                 615                 620                 


Pro Leu Ala Leu Gln Ser Thr Phe Ser Cys Asp Ser Glu Gly Ala Ser 
625                 630                 635                 640 


Ser Phe Phe Ser Asn Ala Ser Asp Ala Asp Gly Tyr Val Ala Ala Glu 
                645                 650                 655     


Leu Leu Ala Lys Asp Val Pro Asp Asp Ala Met Glu Ile Pro Ile Gly 
            660                 665                 670         


Asp Arg Leu Tyr Tyr Gly Glu Tyr Tyr Asn Ala Pro Leu Lys Arg Gly 
        675                 680                 685             


Ser Asp Tyr Cys Ile Ile Leu Arg Ile Thr Ser Glu Trp Asn Lys Val 
    690                 695                 700                 


Arg Arg His Ser Cys Ala Val Trp Ala Gln Val Lys Asp Ser Ser Leu 
705                 710                 715                 720 


Met Leu Leu Gln Met Ala Gly Val Gly Leu Gly Ser Leu Ala Val Val 
                725                 730                 735     


Ile Ile Leu Thr Phe Leu Ser Phe Ser Ala Val 
            740                 745         


<210>  4927
<211>  413
<212>  PRT
<213>  Homo sapiens

<400>  4927

Met Gly Thr Phe Cys Ser Val Ile Lys Phe Glu Asn Leu Gln Glu Leu 
1               5                   10                  15      


Lys Arg Leu Cys His Trp Gly Pro Ile Ile Ala Leu Gly Val Ile Ala 
            20                  25                  30          


Ile Cys Ser Thr Met Ala Met Ile Asp Ser Val Leu Trp Tyr Trp Pro 
        35                  40                  45              


Leu His Thr Thr Gly Gly Ser Val Asn Phe Ile Met Leu Ile Asn Trp 
    50                  55                  60                  


Thr Val Met Ile Leu Tyr Asn Tyr Phe Asn Ala Met Phe Val Gly Pro 
65                  70                  75                  80  


Gly Phe Val Pro Leu Gly Trp Lys Pro Glu Ile Ser Gln Asp Thr Met 
                85                  90                  95      


Tyr Leu Gln Tyr Cys Lys Val Cys Gln Ala Tyr Lys Ala Pro Arg Ser 
            100                 105                 110         


His His Cys Arg Lys Cys Asn Arg Cys Val Met Lys Met Asp His His 
        115                 120                 125             


Cys Pro Trp Ile Asn Asn Cys Cys Gly Tyr Gln Asn His Ala Ser Phe 
    130                 135                 140                 


Thr Leu Phe Leu Leu Leu Ala Pro Leu Gly Cys Ile His Ala Ala Phe 
145                 150                 155                 160 


Ile Phe Val Met Thr Met Tyr Thr Gln Leu Tyr His Arg Leu Ser Phe 
                165                 170                 175     


Gly Trp Asn Thr Val Lys Ile Asp Met Ser Ala Ala Arg Arg Asp Pro 
            180                 185                 190         


Leu Pro Ile Val Pro Phe Gly Leu Ala Ala Phe Ala Thr Thr Leu Phe 
        195                 200                 205             


Ala Leu Gly Leu Ala Leu Gly Thr Thr Ile Ala Val Gly Met Leu Phe 
    210                 215                 220                 


Phe Ile Gln Met Lys Ile Ile Leu Arg Asn Lys Thr Ser Ile Glu Ser 
225                 230                 235                 240 


Trp Ile Glu Glu Lys Ala Lys Asp Arg Ile Gln Tyr Tyr Gln Leu Asp 
                245                 250                 255     


Glu Val Phe Val Phe Pro Tyr Asp Met Gly Ser Arg Trp Arg Asn Phe 
            260                 265                 270         


Lys Gln Val Phe Thr Trp Ser Gly Val Pro Glu Gly Asp Gly Leu Glu 
        275                 280                 285             


Trp Pro Val Arg Glu Gly Cys His Gln Tyr Ser Leu Thr Ile Glu Gln 
    290                 295                 300                 


Leu Lys Gln Lys Ala Asp Lys Arg Val Arg Ser Val Arg Tyr Lys Val 
305                 310                 315                 320 


Ile Glu Asp Tyr Ser Gly Ala Cys Cys Pro Leu Asn Lys Gly Ile Lys 
                325                 330                 335     


Thr Phe Phe Thr Ser Pro Cys Thr Glu Glu Pro Arg Ile Gln Leu Gln 
            340                 345                 350         


Lys Gly Glu Phe Ile Leu Ala Thr Arg Gly Leu Arg Tyr Trp Leu Tyr 
        355                 360                 365             


Gly Asp Lys Ile Leu Asp Asp Ser Phe Ile Glu Gly Val Ser Arg Ile 
    370                 375                 380                 


Arg Gly Trp Phe Pro Arg Lys Cys Val Glu Lys Cys Pro Cys Asp Ala 
385                 390                 395                 400 


Glu Thr Asp Gln Ala Pro Glu Gly Glu Lys Lys Asn Arg 
                405                 410             


<210>  4928
<211>  607
<212>  PRT
<213>  Homo sapiens

<400>  4928

Met Ile Leu Leu Thr Phe Ser Thr Gly Arg Arg Leu Asp Phe Val His 
1               5                   10                  15      


His Ser Gly Val Phe Phe Leu Gln Thr Leu Leu Trp Ile Leu Cys Ala 
            20                  25                  30          


Thr Val Cys Gly Thr Glu Gln Tyr Phe Asn Val Glu Val Trp Leu Gln 
        35                  40                  45              


Lys Tyr Gly Tyr Leu Pro Pro Thr Asp Pro Arg Met Ser Val Leu Arg 
    50                  55                  60                  


Ser Ala Glu Thr Met Gln Ser Ala Leu Ala Ala Met Gln Gln Phe Tyr 
65                  70                  75                  80  


Gly Ile Asn Met Thr Gly Lys Val Asp Arg Asn Thr Ile Asp Trp Met 
                85                  90                  95      


Lys Lys Pro Arg Cys Gly Val Pro Asp Gln Thr Arg Gly Ser Ser Lys 
            100                 105                 110         


Phe His Ile Arg Arg Lys Arg Tyr Ala Leu Thr Gly Gln Lys Trp Gln 
        115                 120                 125             


His Lys His Ile Thr Tyr Ser Ile Lys Asn Val Thr Pro Lys Val Gly 
    130                 135                 140                 


Asp Pro Glu Thr Arg Lys Ala Ile Arg Arg Ala Phe Asp Val Trp Gln 
145                 150                 155                 160 


Asn Val Thr Pro Leu Thr Phe Glu Glu Val Pro Tyr Ser Glu Leu Glu 
                165                 170                 175     


Asn Gly Lys Arg Asp Val Asp Ile Thr Ile Ile Phe Ala Ser Gly Phe 
            180                 185                 190         


His Gly Asp Ser Ser Pro Phe Asp Gly Glu Gly Gly Phe Leu Ala His 
        195                 200                 205             


Ala Tyr Phe Pro Gly Pro Gly Ile Gly Gly Asp Thr His Phe Asp Ser 
    210                 215                 220                 


Asp Glu Pro Trp Thr Leu Gly Asn Pro Asn His Asp Gly Asn Asp Leu 
225                 230                 235                 240 


Phe Leu Val Ala Val His Glu Leu Gly His Ala Leu Gly Leu Glu His 
                245                 250                 255     


Ser Asn Asp Pro Thr Ala Ile Met Ala Pro Phe Tyr Gln Tyr Met Glu 
            260                 265                 270         


Thr Asp Asn Phe Lys Leu Pro Asn Asp Asp Leu Gln Gly Ile Gln Lys 
        275                 280                 285             


Ile Tyr Gly Pro Pro Asp Lys Ile Pro Pro Pro Thr Arg Pro Leu Pro 
    290                 295                 300                 


Thr Val Pro Pro His Arg Ser Ile Pro Pro Ala Asp Pro Arg Lys Asn 
305                 310                 315                 320 


Asp Arg Pro Lys Pro Pro Arg Pro Pro Thr Gly Arg Pro Ser Tyr Pro 
                325                 330                 335     


Gly Ala Lys Pro Asn Ile Cys Asp Gly Asn Phe Asn Thr Leu Ala Ile 
            340                 345                 350         


Leu Arg Arg Glu Met Phe Val Phe Lys Asp Gln Trp Phe Trp Arg Val 
        355                 360                 365             


Arg Asn Asn Arg Val Met Asp Gly Tyr Pro Met Gln Ile Thr Tyr Phe 
    370                 375                 380                 


Trp Arg Gly Leu Pro Pro Ser Ile Asp Ala Val Tyr Glu Asn Ser Asp 
385                 390                 395                 400 


Gly Asn Phe Val Phe Phe Lys Gly Asn Lys Tyr Trp Val Phe Lys Asp 
                405                 410                 415     


Thr Thr Leu Gln Pro Gly Tyr Pro His Asp Leu Ile Thr Leu Gly Ser 
            420                 425                 430         


Gly Ile Pro Pro His Gly Ile Asp Ser Ala Ile Trp Trp Glu Asp Val 
        435                 440                 445             


Gly Lys Thr Tyr Phe Phe Lys Gly Asp Arg Tyr Trp Arg Tyr Ser Glu 
    450                 455                 460                 


Glu Met Lys Thr Met Asp Pro Gly Tyr Pro Lys Pro Ile Thr Val Trp 
465                 470                 475                 480 


Lys Gly Ile Pro Glu Ser Pro Gln Gly Ala Phe Val His Lys Glu Asn 
                485                 490                 495     


Gly Phe Thr Tyr Phe Tyr Lys Gly Lys Glu Tyr Trp Lys Phe Asn Asn 
            500                 505                 510         


Gln Ile Leu Lys Val Glu Pro Gly Tyr Pro Arg Ser Ile Leu Lys Asp 
        515                 520                 525             


Phe Met Gly Cys Asp Gly Pro Thr Asp Arg Val Lys Glu Gly His Ser 
    530                 535                 540                 


Pro Pro Asp Asp Val Asp Ile Val Ile Lys Leu Asp Asn Thr Ala Ser 
545                 550                 555                 560 


Thr Val Lys Ala Ile Ala Ile Val Ile Pro Cys Ile Leu Ala Leu Cys 
                565                 570                 575     


Leu Leu Val Leu Val Tyr Thr Val Phe Gln Phe Lys Arg Lys Gly Thr 
            580                 585                 590         


Pro Arg His Ile Leu Tyr Cys Lys Arg Ser Met Gln Glu Trp Val 
        595                 600                 605         


<210>  4929
<211>  938
<212>  PRT
<213>  Homo sapiens

<400>  4929

Met Pro Ala Leu Glu His Met Asn Gln Ile Leu His Ile Leu Phe Val 
1               5                   10                  15      


Phe Leu Pro Phe Leu Trp Ala Leu Gly Thr Leu Pro Pro Pro Asp Ala 
            20                  25                  30          


Leu Leu Leu Trp Ala Met Glu Gln Val Leu Glu Phe Gly Leu Gly Gly 
        35                  40                  45              


Ser Ser Met Ser Thr His Leu Arg Leu Leu Val Met Phe Ile Met Ser 
    50                  55                  60                  


Ala Gly Thr Ala Ile Ala Ser Tyr Phe Ile Pro Ser Thr Val Gly Val 
65                  70                  75                  80  


Val Leu Phe Met Thr Gly Phe Gly Phe Leu Leu Ser Leu Asn Leu Ser 
                85                  90                  95      


Asp Met Gly His Lys Ile Gly Thr Lys Ser Lys Asp Leu Pro Ser Gly 
            100                 105                 110         


Pro Glu Lys His Phe Ser Trp Lys Glu Cys Leu Phe Tyr Ile Ile Ile 
        115                 120                 125             


Leu Val Leu Ala Leu Leu Glu Thr Ser Leu Leu His His Phe Ala Gly 
    130                 135                 140                 


Phe Ser Gln Ile Ser Lys Ser Asn Ser Gln Ala Ile Val Gly Tyr Gly 
145                 150                 155                 160 


Leu Met Ile Leu Leu Ile Ile Leu Trp Ile Leu Arg Glu Ile Gln Ser 
                165                 170                 175     


Val Tyr Ile Ile Gly Ile Phe Arg Asn Pro Phe Tyr Pro Lys Asp Val 
            180                 185                 190         


Gln Thr Val Thr Val Phe Phe Glu Lys Gln Thr Arg Leu Met Lys Ile 
        195                 200                 205             


Gly Ile Val Arg Arg Ile Leu Leu Thr Leu Val Ser Pro Phe Ala Met 
    210                 215                 220                 


Ile Ala Phe Leu Ser Leu Asp Ser Ser Leu Gln Gly Leu His Ser Val 
225                 230                 235                 240 


Ser Val Cys Ile Gly Phe Thr Arg Ala Phe Arg Met Val Trp Gln Asn 
                245                 250                 255     


Thr Glu Asn Ala Leu Leu Glu Thr Val Ile Val Ser Thr Val His Leu 
            260                 265                 270         


Ile Ser Ser Thr Asp Ile Trp Trp Asn Arg Ser Leu Asp Thr Gly Leu 
        275                 280                 285             


Arg Leu Leu Leu Val Gly Ile Ile Arg Asp Arg Leu Ile Gln Phe Ile 
    290                 295                 300                 


Ser Lys Leu Gln Phe Ala Val Thr Val Leu Leu Thr Ser Trp Thr Glu 
305                 310                 315                 320 


Lys Lys Gln Arg Arg Lys Thr Thr Ala Thr Leu Cys Ile Leu Asn Ile 
                325                 330                 335     


Val Phe Ser Pro Phe Val Leu Val Ile Ile Val Phe Ser Thr Leu Leu 
            340                 345                 350         


Ser Ser Pro Leu Leu Pro Leu Phe Thr Leu Pro Val Phe Leu Val Gly 
        355                 360                 365             


Phe Pro Arg Pro Ile Gln Ser Trp Pro Gly Ala Ala Gly Thr Thr Ala 
    370                 375                 380                 


Cys Val Cys Ala Asp Thr Val Tyr Tyr Tyr Gln Met Val Pro Arg Leu 
385                 390                 395                 400 


Thr Ala Val Leu Gln Thr Ala Met Ala Ala Gly Ser Leu Gly Leu Leu 
                405                 410                 415     


Leu Pro Gly Ser His Tyr Leu Gly Arg Phe Gln Asp Arg Leu Met Trp 
            420                 425                 430         


Ile Met Ile Leu Glu Cys Gly Tyr Thr Tyr Cys Ser Ile Asn Ile Lys 
        435                 440                 445             


Gly Leu Glu Leu Gln Glu Thr Ser Cys His Thr Ala Glu Ala Arg Arg 
    450                 455                 460                 


Val Asp Glu Val Phe Glu Asp Ala Phe Glu Gln Glu Tyr Thr Arg Val 
465                 470                 475                 480 


Cys Ser Leu Asn Glu His Phe Gly Asn Val Leu Thr Pro Cys Thr Val 
                485                 490                 495     


Leu Pro Val Lys Leu Tyr Ser Asp Ala Arg Asn Val Leu Ser Gly Ile 
            500                 505                 510         


Ile Asp Ser His Glu Asn Leu Lys Glu Phe Lys Gly Asp Leu Ile Lys 
        515                 520                 525             


Val Leu Val Trp Ile Leu Val Gln Tyr Cys Ser Lys Arg Pro Gly Met 
    530                 535                 540                 


Lys Glu Asn Val His Asn Thr Glu Asn Lys Gly Lys Ala Pro Leu Met 
545                 550                 555                 560 


Leu Pro Ala Leu Asn Thr Leu Pro Pro Pro Lys Ser Pro Glu Asp Ile 
                565                 570                 575     


Asp Ser Leu Asn Ser Glu Thr Phe Asn Asp Trp Ser Asp Asp Asn Ile 
            580                 585                 590         


Phe Asp Asp Glu Pro Thr Ile Lys Lys Val Ile Glu Glu Lys His Gln 
        595                 600                 605             


Leu Lys Asp Leu Pro Gly Thr Asn Leu Phe Ile Pro Gly Ser Val Glu 
    610                 615                 620                 


Ser Gln Arg Val Gly Asp His Ser Thr Gly Thr Val Pro Glu Asn Asp 
625                 630                 635                 640 


Leu Tyr Lys Ala Val Leu Leu Gly Tyr Pro Ala Val Asp Lys Gly Lys 
                645                 650                 655     


Gln Glu Asp Met Pro Tyr Ile Pro Leu Met Glu Phe Ser Cys Ser His 
            660                 665                 670         


Ser His Leu Val Cys Leu Pro Ala Glu Trp Arg Thr Ser Cys Met Pro 
        675                 680                 685             


Ser Ser Lys Met Lys Glu Met Ser Ser Leu Phe Pro Glu Asp Trp Tyr 
    690                 695                 700                 


Gln Phe Val Leu Arg Gln Leu Glu Cys Tyr His Ser Glu Glu Lys Ala 
705                 710                 715                 720 


Ser Asn Val Leu Glu Glu Ile Ala Lys Asp Lys Val Leu Lys Asp Phe 
                725                 730                 735     


Tyr Val His Thr Val Met Thr Cys Tyr Phe Ser Leu Phe Gly Ile Asp 
            740                 745                 750         


Asn Met Ala Pro Ser Pro Gly His Ile Leu Arg Val Tyr Gly Gly Val 
        755                 760                 765             


Leu Pro Trp Ser Val Ala Leu Asp Trp Leu Thr Glu Lys Pro Glu Leu 
    770                 775                 780                 


Phe Gln Leu Ala Leu Lys Ala Phe Arg Tyr Thr Leu Lys Leu Met Ile 
785                 790                 795                 800 


Asp Lys Ala Ser Leu Gly Pro Ile Glu Asp Phe Arg Glu Leu Ile Lys 
                805                 810                 815     


Tyr Leu Glu Glu Tyr Glu Arg Asp Trp Tyr Ile Gly Leu Val Ser Asp 
            820                 825                 830         


Glu Lys Trp Lys Glu Ala Ile Leu Gln Glu Lys Pro Tyr Leu Phe Ser 
        835                 840                 845             


Leu Gly Tyr Asp Ser Asn Met Gly Ile Tyr Thr Gly Arg Val Leu Ser 
    850                 855                 860                 


Leu Gln Glu Leu Leu Ile Gln Val Gly Lys Leu Asn Pro Glu Ala Val 
865                 870                 875                 880 


Arg Gly Gln Trp Ala Asn Leu Ser Trp Glu Leu Leu Tyr Ala Thr Asn 
                885                 890                 895     


Asp Asp Glu Glu Arg Tyr Ser Ile Gln Ala His Pro Leu Leu Leu Arg 
            900                 905                 910         


Asn Leu Thr Val Gln Ala Ala Glu Pro Pro Leu Gly Tyr Pro Ile Tyr 
        915                 920                 925             


Ser Ser Lys Pro Leu His Ile His Leu Tyr 
    930                 935             


<210>  4930
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  4930

Met Lys Gly Arg Gly Met Leu Val Leu Leu Leu His Ala Val Val Leu 
1               5                   10                  15      


Gly Leu Pro Ser Ala Trp Ala Val Gly Ala Cys Ala Arg Ala Cys Pro 
            20                  25                  30          


Ala Ala Cys Ala Cys Ser Thr Val Glu Arg Gly Cys Ser Val Arg Cys 
        35                  40                  45              


Asp Arg Ala Gly Leu Leu Arg Val Pro Ala Glu Leu Pro Cys Glu Ala 
    50                  55                  60                  


Val Ser Ile Asp Leu Asp Arg Asn Gly Leu Arg Phe Leu Gly Glu Arg 
65                  70                  75                  80  


Ala Phe Gly Thr Leu Pro Ser Leu Arg Arg Leu Ser Leu Arg His Asn 
                85                  90                  95      


Asn Leu Ser Phe Ile Thr Pro Gly Ala Phe Lys Gly Leu Pro Arg Leu 
            100                 105                 110         


Ala Glu Leu Arg Leu Ala His Asn Gly Asp Leu Arg Tyr Leu His Ala 
        115                 120                 125             


Arg Thr Phe Ala Ala Leu Ser Arg Leu Arg Arg Leu Asp Leu Ala Ala 
    130                 135                 140                 


Cys Arg Leu Phe Ser Val Pro Glu Arg Leu Leu Ala Glu Leu Pro Ala 
145                 150                 155                 160 


Leu Arg Glu Leu Ala Ala Phe Asp Asn Leu Phe Arg Arg Val Pro Gly 
                165                 170                 175     


Ala Leu Arg Gly Leu Ala Asn Leu Thr His Ala His Leu Glu Arg Gly 
            180                 185                 190         


Arg Ile Glu Ala Val Ala Ser Ser Ser Leu Gln Gly Leu Arg Arg Leu 
        195                 200                 205             


Arg Ser Leu Ser Leu Gln Ala Asn Arg Val Arg Ala Val His Ala Gly 
    210                 215                 220                 


Ala Phe Gly Asp Cys Gly Val Leu Glu His Leu Leu Leu Asn Asp Asn 
225                 230                 235                 240 


Leu Leu Ala Glu Leu Pro Ala Asp Ala Phe Arg Gly Leu Arg Arg Leu 
                245                 250                 255     


Arg Thr Leu Asn Leu Gly Gly Asn Ala Leu Asp Arg Val Ala Arg Ala 
            260                 265                 270         


Trp Phe Ala Asp Leu Ala Glu Leu Glu Leu Leu Tyr Leu Asp Arg Asn 
        275                 280                 285             


Ser Ile Ala Phe Val Glu Glu Gly Ala Phe Gln Asn Leu Ser Gly Leu 
    290                 295                 300                 


Leu Ala Leu His Leu Asn Gly Asn Arg Leu Thr Val Leu Ala Trp Val 
305                 310                 315                 320 


Ala Phe Gln Pro Gly Phe Phe Leu Gly Arg Leu Phe Leu Phe Arg Asn 
                325                 330                 335     


Pro Trp Cys Cys Asp Cys Arg Leu Glu Trp Leu Arg Asp Trp Met Glu 
            340                 345                 350         


Gly Ser Gly Arg Val Thr Asp Val Pro Cys Ala Ser Pro Gly Ser Val 
        355                 360                 365             


Ala Gly Leu Asp Leu Ser Gln Val Thr Phe Gly Arg Ser Ser Asp Gly 
    370                 375                 380                 


Leu Cys Val Asp Pro Glu Glu Leu Asn Leu Thr Thr Ser Ser Pro Gly 
385                 390                 395                 400 


Pro Ser Pro Glu Pro Ala Ala Thr Thr Val Ser Arg Phe Ser Ser Leu 
                405                 410                 415     


Leu Ser Lys Leu Leu Ala Pro Arg Val Pro Val Glu Glu Ala Ala Asn 
            420                 425                 430         


Thr Thr Gly Gly Leu Ala Asn Ala Ser Leu Ser Asp Ser Leu Ser Ser 
        435                 440                 445             


Arg Gly Val Gly Gly Ala Gly Arg Gln Pro Trp Phe Leu Leu Ala Ser 
    450                 455                 460                 


Cys Leu Leu Pro Ser Val Ala Gln His Val Val Phe Gly Leu Gln Met 
465                 470                 475                 480 


Asp 
    


<210>  4931
<211>  872
<212>  PRT
<213>  Homo sapiens

<400>  4931

Met Asn Leu Ile Val Lys Leu Arg Arg Ser Phe Arg Thr Leu Ile Val 
1               5                   10                  15      


Leu Leu Ala Thr Phe Cys Leu Val Ser Ile Val Ile Ser Ala Tyr Phe 
            20                  25                  30          


Leu Tyr Ser Gly Tyr Lys Gln Glu Met Thr Leu Ile Glu Thr Thr Ala 
        35                  40                  45              


Glu Ala Glu Cys Thr Asp Ile Lys Ile Leu Pro Tyr Arg Ser Met Glu 
    50                  55                  60                  


Leu Lys Thr Val Lys Pro Ile Asp Thr Ser Lys Thr Asp Pro Thr Val 
65                  70                  75                  80  


Leu Leu Phe Val Glu Ser Gln Tyr Ser Gln Leu Gly Gln Asp Ile Ile 
                85                  90                  95      


Ala Ile Leu Glu Ser Ser Arg Phe Gln Tyr His Met Val Ile Ala Pro 
            100                 105                 110         


Gly Lys Gly Asp Ile Pro Pro Leu Thr Asp Asn Gly Lys Gly Lys Tyr 
        115                 120                 125             


Thr Leu Val Ile Tyr Glu Asn Ile Leu Lys Tyr Val Ser Met Asp Ser 
    130                 135                 140                 


Trp Asn Arg Glu Leu Leu Glu Lys Tyr Cys Val Glu Tyr Ser Val Ser 
145                 150                 155                 160 


Ile Ile Gly Phe His Lys Ala Asn Glu Asn Ser Leu Pro Ser Thr Gln 
                165                 170                 175     


Leu Lys Gly Phe Pro Leu Asn Leu Phe Asn Asn Leu Ala Leu Lys Asp 
            180                 185                 190         


Cys Phe Val Asn Pro Gln Ser Pro Leu Leu His Ile Thr Lys Ala Pro 
        195                 200                 205             


Lys Val Glu Lys Gly Pro Leu Pro Gly Glu Asp Trp Thr Ile Phe Gln 
    210                 215                 220                 


Tyr Asn His Ser Thr Tyr Gln Pro Val Leu Leu Thr Glu Leu Gln Thr 
225                 230                 235                 240 


Glu Lys Ser Leu Ser Ser Leu Ser Ser Lys Thr Leu Phe Ala Thr Val 
                245                 250                 255     


Ile Gln Asp Leu Gly Leu His Asp Gly Ile Gln Arg Val Leu Phe Gly 
            260                 265                 270         


Asn Asn Leu Asn Phe Trp Leu His Lys Leu Ile Phe Ile Asp Ala Ile 
        275                 280                 285             


Ser Phe Leu Ser Gly Lys Arg Leu Thr Leu Ser Leu Asp Arg Tyr Ile 
    290                 295                 300                 


Leu Val Asp Ile Asp Asp Ile Phe Val Gly Lys Glu Gly Thr Arg Met 
305                 310                 315                 320 


Asn Val Lys Asp Val Lys Ala Leu Leu Glu Thr Gln Asn Leu Leu Arg 
                325                 330                 335     


Thr Gln Val Ala Asn Phe Thr Phe Asn Leu Gly Phe Ser Gly Lys Phe 
            340                 345                 350         


Tyr His Thr Gly Thr Glu Glu Glu Asp Glu Gly Asp Asp Leu Leu Leu 
        355                 360                 365             


Arg Ser Val Asp Glu Phe Trp Trp Phe Pro His Met Trp Ser His Met 
    370                 375                 380                 


Gln Pro His Leu Phe His Asn Glu Ser Ser Leu Val Glu Gln Met Ile 
385                 390                 395                 400 


Leu Asn Lys Glu Phe Ala Leu Glu His Gly Ile Pro Ile Asn Met Gly 
                405                 410                 415     


Tyr Ala Val Ala Pro His His Ser Gly Val Tyr Pro Val His Ile Gln 
            420                 425                 430         


Leu Tyr Ala Ala Trp Lys Lys Val Trp Gly Ile Gln Val Thr Ser Thr 
        435                 440                 445             


Glu Glu Tyr Pro His Leu Lys Pro Ala Arg Tyr Arg Lys Gly Phe Ile 
    450                 455                 460                 


His Asn Ser Ile Met Val Leu Pro Arg Gln Thr Cys Gly Leu Phe Thr 
465                 470                 475                 480 


His Thr Ile Phe Tyr Lys Glu Tyr Pro Gly Gly Pro Gln Glu Leu Asp 
                485                 490                 495     


Lys Ser Ile Arg Gly Gly Glu Leu Phe Leu Thr Ile Leu Leu Asn Pro 
            500                 505                 510         


Ile Ser Ile Phe Met Thr His Leu Ser Asn Tyr Gly Asn Asp Arg Leu 
        515                 520                 525             


Gly Leu Tyr Thr Phe Val Asn Leu Val Asn Phe Val Gln Ser Trp Thr 
    530                 535                 540                 


Asn Leu Lys Leu Gln Thr Leu Pro Pro Val Gln Leu Ala His Gln Tyr 
545                 550                 555                 560 


Phe Glu Leu Phe Pro Glu Gln Lys Asp Pro Leu Trp Gln Asn Pro Cys 
                565                 570                 575     


Asp Asp Lys Arg His Lys Asp Ile Trp Ser Arg Glu Lys Thr Cys Asp 
            580                 585                 590         


His Leu Pro Lys Phe Leu Val Ile Gly Pro Gln Lys Thr Gly Thr Thr 
        595                 600                 605             


Ala Leu Tyr Leu Phe Leu Leu Met His Pro Ser Ile Ile Ser Asn Leu 
    610                 615                 620                 


Pro Ser Pro Lys Thr Phe Glu Glu Val Gln Phe Phe Asn Gly Asn Asn 
625                 630                 635                 640 


Tyr His Lys Gly Ile Asp Trp Tyr Met Asp Phe Phe Pro Thr Pro Ser 
                645                 650                 655     


Asn Thr Thr Ser Asp Phe Leu Phe Glu Lys Ser Ala Asn Tyr Phe His 
            660                 665                 670         


Ser Glu Glu Ala Pro Arg Arg Ala Ala Ser Leu Val Pro Lys Ala Lys 
        675                 680                 685             


Ile Ile Thr Ile Leu Ile Asp Pro Ser Asp Arg Ala Tyr Ser Trp Tyr 
    690                 695                 700                 


Gln His Gln Arg Ser His Glu Asp Pro Ala Ala Leu Arg Phe Asn Phe 
705                 710                 715                 720 


Tyr Glu Val Ile Ser Thr Gly His Trp Ala Pro Ser Asp Leu Lys Thr 
                725                 730                 735     


Leu Gln Arg Arg Cys Leu Val Pro Gly Trp Tyr Ala Val His Ile Glu 
            740                 745                 750         


Arg Trp Leu Thr Tyr Phe Ala Thr Ser Gln Leu Leu Ile Ile Asp Gly 
        755                 760                 765             


Gln Gln Leu Arg Ser Asp Pro Ala Thr Val Met Asp Glu Val Gln Lys 
    770                 775                 780                 


Phe Leu Gly Val Thr Pro Arg Tyr Asn Tyr Ser Glu Ala Leu Thr Phe 
785                 790                 795                 800 


Asp Pro Gln Lys Gly Phe Trp Cys Gln Leu Leu Glu Gly Gly Lys Thr 
                805                 810                 815     


Lys Cys Leu Gly Lys Ser Lys Gly Arg Lys Tyr Pro Pro Met Asp Pro 
            820                 825                 830         


Glu Ser Arg Thr Phe Leu Ser Asn Tyr Tyr Arg Asp His Asn Val Glu 
        835                 840                 845             


Leu Ser Lys Leu Leu His Arg Leu Gly Gln Pro Leu Pro Ser Trp Leu 
    850                 855                 860                 


Arg Gln Glu Leu Gln Lys Val Arg 
865                 870         


<210>  4932
<211>  494
<212>  PRT
<213>  Homo sapiens

<400>  4932

Met Glu Glu Pro Gln Pro Pro Arg Pro Pro Ala Ser Met Ala Leu Leu 
1               5                   10                  15      


Gly Ser Gln His Ser Gly Ala Pro Ser Ala Ala Gly Pro Pro Gly Gly 
            20                  25                  30          


Thr Ser Ser Ala Ala Thr Ala Ala Val Leu Ser Phe Ser Thr Val Ala 
        35                  40                  45              


Thr Ala Ala Leu Gly Asn Leu Ser Asp Ala Ser Gly Gly Gly Thr Ala 
    50                  55                  60                  


Ala Ala Pro Gly Gly Gly Gly Leu Gly Gly Ser Gly Ala Ala Arg Glu 
65                  70                  75                  80  


Ala Gly Ala Ala Val Arg Arg Pro Leu Gly Pro Glu Ala Ala Pro Leu 
                85                  90                  95      


Leu Ser His Gly Ala Ala Val Ala Ala Gln Ala Leu Val Leu Leu Leu 
            100                 105                 110         


Ile Phe Leu Leu Ser Ser Leu Gly Asn Cys Ala Val Met Gly Val Ile 
        115                 120                 125             


Val Lys His Arg Gln Leu Arg Thr Val Thr Asn Ala Phe Ile Leu Ser 
    130                 135                 140                 


Leu Ser Leu Ser Asp Leu Leu Thr Ala Leu Leu Cys Leu Pro Ala Ala 
145                 150                 155                 160 


Phe Leu Asp Leu Phe Thr Pro Pro Gly Gly Ser Ala Pro Ala Ala Ala 
                165                 170                 175     


Ala Gly Pro Trp Arg Gly Phe Cys Ala Ala Ser Arg Phe Phe Ser Ser 
            180                 185                 190         


Cys Phe Gly Ile Val Ser Thr Leu Ser Val Ala Leu Ile Ser Leu Asp 
        195                 200                 205             


Arg Tyr Cys Ala Ile Val Arg Pro Pro Arg Glu Lys Ile Gly Arg Arg 
    210                 215                 220                 


Arg Ala Leu Gln Leu Leu Ala Gly Ala Trp Leu Thr Ala Leu Gly Phe 
225                 230                 235                 240 


Ser Leu Pro Trp Glu Leu Leu Gly Ala Pro Arg Glu Leu Ala Ala Ala 
                245                 250                 255     


Gln Ser Phe His Gly Cys Leu Tyr Arg Thr Ser Pro Asp Pro Ala Gln 
            260                 265                 270         


Leu Gly Ala Ala Phe Ser Val Gly Leu Val Val Ala Cys Tyr Leu Leu 
        275                 280                 285             


Pro Phe Leu Leu Met Cys Phe Cys His Tyr His Ile Cys Lys Thr Val 
    290                 295                 300                 


Arg Leu Ser Asp Val Arg Val Arg Pro Val Asn Thr Tyr Ala Arg Val 
305                 310                 315                 320 


Leu Arg Phe Phe Ser Glu Val Arg Thr Ala Thr Thr Val Leu Ile Met 
                325                 330                 335     


Ile Val Phe Val Ile Cys Cys Trp Gly Pro Tyr Cys Phe Leu Val Leu 
            340                 345                 350         


Leu Ala Ala Ala Arg Gln Ala Gln Thr Met Gln Ala Pro Ser Leu Leu 
        355                 360                 365             


Ser Val Val Ala Val Trp Leu Thr Trp Ala Asn Gly Ala Ile Asn Pro 
    370                 375                 380                 


Val Ile Tyr Ala Ile Arg Asn Pro Asn Ile Ser Met Leu Leu Gly Arg 
385                 390                 395                 400 


Asn Arg Glu Glu Gly Tyr Arg Thr Arg Asn Val Asp Ala Phe Leu Pro 
                405                 410                 415     


Ser Gln Gly Pro Gly Leu Gln Ala Arg Ser Arg Ser Arg Leu Arg Asn 
            420                 425                 430         


Arg Tyr Ala Asn Arg Leu Gly Ala Cys Asn Arg Met Ser Ser Ser Asn 
        435                 440                 445             


Pro Ala Ser Gly Val Ala Gly Asp Val Ala Met Trp Ala Arg Lys Asn 
    450                 455                 460                 


Pro Val Val Leu Phe Cys Arg Glu Gly Pro Pro Glu Pro Val Thr Ala 
465                 470                 475                 480 


Val Thr Lys Gln Pro Lys Ser Glu Ala Gly Asp Thr Ser Leu 
                485                 490                 


<210>  4933
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  4933

Met Ala Pro Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Thr Val Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp His Ala Met Leu Gln Ala His Arg Ala His Gln 
        35                  40                  45              


Leu Ala Ile Asp Thr Tyr Gln Glu Phe Glu Glu Thr Tyr Ile Pro Lys 
    50                  55                  60                  


Asp Gln Lys Tyr Ser Phe Leu His Asp Ser Gln Thr Ser Phe Cys Phe 
65                  70                  75                  80  


Ser Asp Ser Ile Pro Thr Pro Ser Asn Met Glu Glu Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Glu Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Arg Phe Leu Arg Ser Met Phe Ala Asn Asn Leu Val 
        115                 120                 125             


Tyr Asp Thr Ser Asp Ser Asp Asp Tyr His Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Arg Arg 
145                 150                 155                 160 


Thr Gly Gln Ile Leu Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser 
                165                 170                 175     


His Asn His Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe 
            180                 185                 190         


Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Met Val Gln Cys 
        195                 200                 205             


Arg Ser Val Glu Gly Ser Cys Gly Phe 
    210                 215         


<210>  4934
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  4934

Met Ala Pro Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Thr Val Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp His Ala Met Leu Gln Ala His Arg Ala His Gln 
        35                  40                  45              


Leu Ala Ile Asp Thr Tyr Gln Glu Phe Glu Glu Thr Tyr Ile Pro Lys 
    50                  55                  60                  


Asp Gln Lys Tyr Ser Phe Leu His Asp Ser Gln Thr Ser Phe Cys Phe 
65                  70                  75                  80  


Ser Asp Ser Ile Pro Thr Pro Ser Asn Met Glu Glu Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Glu Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Arg Phe Leu Arg Ser Met Phe Ala Asn Asn Leu Val 
        115                 120                 125             


Tyr Asp Thr Ser Asp Ser Asp Asp Tyr His Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Arg Arg 
145                 150                 155                 160 


Thr Gly Gln Ile Leu Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser 
                165                 170                 175     


His Asn His Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe 
            180                 185                 190         


Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Met Val Gln Cys 
        195                 200                 205             


Arg Ser Val Glu Gly Ser Cys Gly Phe 
    210                 215         


<210>  4935
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  4935

Met Ala Trp Gln Gly Trp Pro Ala Ala Trp Gln Trp Val Ala Gly Cys 
1               5                   10                  15      


Trp Leu Leu Leu Val Leu Val Leu Val Leu Leu Val Ser Pro Arg Gly 
            20                  25                  30          


Cys Arg Ala Arg Arg Gly Leu Arg Gly Leu Leu Met Ala His Ser Gln 
        35                  40                  45              


Arg Leu Leu Phe Arg Ile Gly Tyr Ser Leu Tyr Thr Arg Thr Trp Leu 
    50                  55                  60                  


Gly Tyr Leu Phe Tyr Arg Gln Gln Leu Arg Arg Ala Arg Asn Arg Tyr 
65                  70                  75                  80  


Pro Lys Gly His Ser Lys Thr Gln Pro Arg Leu Phe Asn Gly Val Lys 
                85                  90                  95      


Val Leu Pro Ile Pro Val Leu Ser Asp Asn Tyr Ser Tyr Leu Ile Ile 
            100                 105                 110         


Asp Thr Gln Ala Gln Leu Ala Val Ala Val Asp Pro Ser Asp Pro Arg 
        115                 120                 125             


Ala Val Gln Ala Ser Ile Glu Lys Glu Gly Val Thr Leu Val Ala Ile 
    130                 135                 140                 


Leu Cys Thr His Lys His Trp Asp His Ser Gly Gly Asn Arg Asp Leu 
145                 150                 155                 160 


Ser Arg Arg His Arg Asp Cys Arg Val Tyr Gly Ser Pro Gln Asp Gly 
                165                 170                 175     


Ile Pro Tyr Leu Thr His Pro Leu Cys His Gln Asp Val Val Ser Val 
            180                 185                 190         


Gly Arg Leu Gln Ile Arg Ala Leu Ala Thr Pro Gly His Thr Gln Gly 
        195                 200                 205             


His Leu Val Tyr Leu Leu Asp Gly Glu Pro Tyr Lys Gly Pro Ser Cys 
    210                 215                 220                 


Leu Phe Ser Gly Asp Leu Leu Phe Leu Ser Gly Cys Gly Arg Thr Phe 
225                 230                 235                 240 


Glu Gly Asn Ala Glu Thr Met Leu Ser Ser Leu Asp Thr Val Leu Gly 
                245                 250                 255     


Leu Gly Asp Asp Thr Leu Leu Trp Pro Gly His Glu Tyr Ala Glu Glu 
            260                 265                 270         


Asn Leu Gly Phe Ala Gly Val Val Glu Pro Glu Asn Leu Ala Arg Glu 
        275                 280                 285             


Arg Lys Met Gln Trp Val Gln Arg Gln Arg Leu Glu Arg Lys Gly Thr 
    290                 295                 300                 


Cys Pro Ser Thr Leu Gly Glu Glu Arg Ser Tyr Asn Pro Phe Leu Arg 
305                 310                 315                 320 


Thr His Cys Leu Ala Leu Gln Glu Ala Leu Gly Pro Gly Pro Gly Pro 
                325                 330                 335     


Thr Gly Asp Asp Asp Tyr Ser Arg Ala Gln Leu Leu Glu Glu Leu Arg 
            340                 345                 350         


Arg Leu Lys Asp Met His Lys Ser Lys 
        355                 360     


<210>  4936
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  4936

Met Gly Thr Thr Ala Arg Ala Ala Leu Val Leu Thr Tyr Leu Ala Val 
1               5                   10                  15      


Ala Ser Ala Ala Ser Glu Gly Gly Phe Thr Ala Thr Gly Gln Arg Gln 
            20                  25                  30          


Leu Arg Pro Glu His Phe Gln Glu Val Gly Tyr Ala Ala Pro Pro Ser 
        35                  40                  45              


Pro Pro Leu Ser Arg Ser Leu Pro Met Asp His Pro Asp Ser Ser Gln 
    50                  55                  60                  


His Gly Pro Pro Phe Glu Gly Gln Ser Gln Val Gln Pro Pro Pro Ser 
65                  70                  75                  80  


Gln Glu Ala Thr Pro Leu Gln Gln Glu Lys Leu Leu Pro Ala Gln Leu 
                85                  90                  95      


Pro Ala Glu Lys Glu Val Gly Pro Pro Leu Pro Gln Glu Ala Val Pro 
            100                 105                 110         


Leu Gln Lys Glu Leu Pro Ser Leu Gln His Pro Asn Glu Gln Lys Glu 
        115                 120                 125             


Gly Thr Pro Ala Pro Phe Gly Asp Gln Ser His Pro Glu Pro Glu Ser 
    130                 135                 140                 


Trp Asn Ala Ala Gln His Cys Gln Gln Asp Arg Ser Gln Gly Gly Trp 
145                 150                 155                 160 


Gly His Arg Leu Asp Gly Phe Pro Pro Gly Arg Pro Ser Pro Asp Asn 
                165                 170                 175     


Leu Asn Gln Ile Cys Leu Pro Asn Arg Gln His Val Val Tyr Gly Pro 
            180                 185                 190         


Trp Asn Leu Pro Gln Ser Ser Tyr Ser His Leu Thr Arg Gln Gly Glu 
        195                 200                 205             


Thr Leu Asn Phe Leu Glu Ile Gly Tyr Ser Arg Cys Cys His Cys Arg 
    210                 215                 220                 


Ser His Thr Asn Arg Leu Glu Cys Ala Lys Leu Val Trp Glu Asp Thr 
225                 230                 235                 240 


Leu Asp Lys Tyr Cys Asp Arg Glu Tyr Ala Val Lys Thr His His His 
                245                 250                 255     


Leu Cys Cys Arg His Pro Pro Ser Pro Thr Arg Asp Glu Cys Phe Ala 
            260                 265                 270         


Arg Arg Ala Pro Tyr Pro Asn Tyr Asp Arg Asp Ile Leu Thr Ile Asp 
        275                 280                 285             


Ile Gly Arg Val Thr Pro Asn Leu Met Gly His Leu Cys Gly Asn Gln 
    290                 295                 300                 


Arg Val Leu Thr Lys His Lys His Ile Pro Gly Leu Ile His Asn Met 
305                 310                 315                 320 


Thr Ala Arg Cys Cys Asp Leu Pro Phe Pro Glu Gln Ala Cys Cys Ala 
                325                 330                 335     


Glu Glu Glu Lys Leu Thr Phe Ile Asn Asp Leu Cys Gly Pro Arg Arg 
            340                 345                 350         


Asn Ile Trp Arg Asp Pro Ala Leu Cys Cys Tyr Leu Ser Pro Gly Asp 
        355                 360                 365             


Glu Gln Val Asn Cys Phe Asn Ile Asn Tyr Leu Arg Asn Val Ala Leu 
    370                 375                 380                 


Val Ser Gly Asp Thr Glu Asn Ala Lys Gly Gln Gly Glu Gln Gly Ser 
385                 390                 395                 400 


Thr Gly Gly Thr Asn Ile Ser Ser Thr Ser Glu Pro Lys Glu Glu 
                405                 410                 415 


<210>  4937
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  4937

Met Gly Leu Leu Asp Ser Glu Pro Gly Ser Val Leu Asn Val Val Ser 
1               5                   10                  15      


Thr Ala Leu Asn Asp Thr Val Glu Phe Tyr Arg Trp Thr Trp Ser Ile 
            20                  25                  30          


Ala Asp Lys Arg Val Glu Asn Trp Pro Leu Met Gln Ser Pro Trp Pro 
        35                  40                  45              


Thr Leu Ser Ile Ser Thr Leu Tyr Leu Leu Phe Val Trp Leu Gly Pro 
    50                  55                  60                  


Lys Trp Met Lys Asp Arg Glu Pro Phe Gln Met Arg Leu Val Leu Ile 
65                  70                  75                  80  


Ile Tyr Asn Phe Gly Met Val Leu Leu Asn Leu Phe Ile Phe Arg Glu 
                85                  90                  95      


Leu Phe Met Gly Ser Tyr Asn Ala Gly Tyr Ser Tyr Ile Cys Gln Ser 
            100                 105                 110         


Val Asp Tyr Ser Asn Asn Val His Glu Val Arg Ile Ala Ala Ala Leu 
        115                 120                 125             


Trp Trp Tyr Phe Val Ser Lys Gly Val Glu Tyr Leu Asp Thr Val Phe 
    130                 135                 140                 


Phe Ile Leu Arg Lys Lys Asn Asn Gln Val Ser Phe Leu His Val Tyr 
145                 150                 155                 160 


His His Cys Thr Met Phe Thr Leu Trp Trp Ile Gly Ile Lys Trp Val 
                165                 170                 175     


Ala Gly Gly Gln Ala Phe Phe Gly Ala Gln Leu Asn Ser Phe Ile His 
            180                 185                 190         


Val Ile Met Tyr Ser Tyr Tyr Gly Leu Thr Ala Phe Gly Pro Trp Ile 
        195                 200                 205             


Gln Lys Tyr Leu Trp Trp Lys Arg Tyr Leu Thr Met Leu Gln Leu Ile 
    210                 215                 220                 


Gln Phe His Val Thr Ile Gly His Thr Ala Leu Ser Leu Tyr Thr Asp 
225                 230                 235                 240 


Cys Pro Phe Pro Lys Trp Met His Trp Ala Leu Ile Ala Tyr Ala Ile 
                245                 250                 255     


Ser Phe Ile Phe Leu Phe Leu Asn Phe Tyr Ile Arg Thr Tyr Lys Glu 
            260                 265                 270         


Pro Lys Lys Pro Lys Ala Gly Lys Thr Ala Met Asn Gly Ile Ser Ala 
        275                 280                 285             


Asn Gly Val Ser Lys Ser Glu Lys Gln Leu Met Ile Glu Asn Gly Lys 
    290                 295                 300                 


Lys Gln Lys Asn Gly Lys Ala Lys Gly Asp 
305                 310                 


<210>  4938
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  4938

Met Gly Val Ala Leu Arg Asp Leu Pro Gly Arg His Val Ser Ser Arg 
1               5                   10                  15      


Ser His Val Thr Ala Val Leu Thr Val Phe His Gly Arg Cys Phe Leu 
            20                  25                  30          


Pro Gly Phe Gly Val Val Thr Thr Phe Pro Ser Pro Ser Pro Ala Gly 
        35                  40                  45              


Ala Met Glu Glu Glu Asp Glu Glu Ala Arg Ala Leu Leu Ala Gly Gly 
    50                  55                  60                  


Pro Asp Glu Ala Asp Arg Gly Ala Pro Ala Ala Pro Gly Ala Leu Pro 
65                  70                  75                  80  


Ala Leu Cys Asp Pro Ser Arg Leu Ala His Arg Leu Leu Val Leu Leu 
                85                  90                  95      


Leu Met Cys Phe Leu Gly Phe Gly Ser Tyr Phe Cys Tyr Asp Asn Pro 
            100                 105                 110         


Ala Ala Leu Gln Thr Gln Val Lys Arg Asp Met Gln Val Asn Thr Thr 
        115                 120                 125             


Lys Phe Met Leu Leu Tyr Ala Trp Tyr Ser Trp Pro Asn Val Val Leu 
    130                 135                 140                 


Cys Phe Phe Gly Gly Phe Leu Ile Asp Arg Val Phe Gly Ile Arg Trp 
145                 150                 155                 160 


Gly Thr Ile Ile Phe Ser Cys Phe Val Cys Ile Gly Gln Val Val Phe 
                165                 170                 175     


Ala Leu Gly Gly Ile Phe Asn Ala Phe Trp Leu Met Glu Phe Gly Arg 
            180                 185                 190         


Phe Val Phe Gly Ile Gly Gly Glu Ser Leu Ala Val Ala Gln Asn Thr 
        195                 200                 205             


Tyr Ala Val Ser Trp Phe Lys Gly Lys Glu Leu Asn Leu Val Phe Gly 
    210                 215                 220                 


Leu Gln Leu Ser Met Ala Arg Ile Gly Ser Thr Val Asn Met Asn Leu 
225                 230                 235                 240 


Met Gly Trp Leu Tyr Ser Lys Ile Glu Ala Leu Leu Gly Ser Ala Gly 
                245                 250                 255     


His Thr Thr Leu Gly Ile Thr Leu Met Ile Gly Gly Ile Thr Cys Ile 
            260                 265                 270         


Leu Ser Leu Ile Cys Ala Leu Ala Leu Ala Tyr Leu Asp Gln Arg Ala 
        275                 280                 285             


Glu Arg Ile Leu His Lys Glu Gln Gly Lys Thr Gly Glu Val Ile Lys 
    290                 295                 300                 


Leu Thr Asp Val Lys Asp Phe Ser Leu Pro Leu Trp Leu Ile Phe Ile 
305                 310                 315                 320 


Ile Cys Val Cys Tyr Tyr Val Ala Val Phe Pro Phe Ile Gly Leu Gly 
                325                 330                 335     


Lys Val Phe Phe Thr Glu Lys Phe Gly Phe Ser Ser Gln Ala Ala Ser 
            340                 345                 350         


Ala Ile Asn Ser Val Val Tyr Val Ile Ser Ala Pro Met Ser Pro Val 
        355                 360                 365             


Phe Gly Leu Leu Val Asp Lys Thr Gly Lys Asn Ile Ile Trp Val Leu 
    370                 375                 380                 


Cys Ala Val Ala Ala Thr Leu Val Ser His Met Met Leu Ala Phe Thr 
385                 390                 395                 400 


Met Trp Asn Pro Trp Ile Ala Met Cys Leu Leu Gly Leu Ser Tyr Ser 
                405                 410                 415     


Leu Leu Ala Cys Ala Leu Trp Pro Met Val Ala Phe Val Val Pro Glu 
            420                 425                 430         


His Gln Leu Gly Thr Ala Tyr Gly Phe Met Gln Ser Ile Gln Asn Leu 
        435                 440                 445             


Gly Leu Ala Ile Ile Ser Ile Ile Ala Gly Met Ile Leu Asp Ser Arg 
    450                 455                 460                 


Gly Tyr Leu Phe Leu Glu Val Phe Phe Ile Ala Cys Val Ser Leu Ser 
465                 470                 475                 480 


Leu Leu Ser Val Val Leu Leu Tyr Leu Val Asn Arg Ala Gln Gly Gly 
                485                 490                 495     


Asn Leu Asn Tyr Ser Ala Arg Gln Arg Glu Glu Ile Lys Phe Ser His 
            500                 505                 510         


Thr Glu 
        


<210>  4939
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  4939

Met Ala Gly Gly Arg Pro His Leu Lys Arg Ser Phe Ser Ile Ile Pro 
1               5                   10                  15      


Cys Phe Val Phe Val Glu Ser Val Leu Leu Gly Ile Val Ile Leu Leu 
            20                  25                  30          


Ala Tyr Arg Leu Glu Phe Thr Asp Thr Phe Pro Val His Thr Gln Gly 
        35                  40                  45              


Phe Phe Cys Tyr Asp Ser Thr Tyr Ala Lys Pro Tyr Pro Gly Pro Glu 
    50                  55                  60                  


Ala Ala Ser Arg Val Pro Pro Ala Leu Val Tyr Ala Leu Val Thr Ala 
65                  70                  75                  80  


Gly Pro Thr Leu Thr Ile Leu Leu Gly Glu Leu Ala Arg Ala Phe Phe 
                85                  90                  95      


Pro Ala Pro Pro Ser Ala Val Pro Val Ile Gly Glu Ser Thr Ile Val 
            100                 105                 110         


Ser Gly Ala Cys Cys Arg Phe Ser Pro Pro Val Arg Arg Leu Val Arg 
        115                 120                 125             


Phe Leu Gly Val Tyr Ser Phe Gly Leu Phe Thr Thr Thr Ile Phe Ala 
    130                 135                 140                 


Asn Ala Gly Gln Val Val Thr Gly Asn Pro Thr Pro His Phe Leu Ser 
145                 150                 155                 160 


Val Cys Arg Pro Asn Tyr Thr Ala Leu Gly Cys Leu Pro Pro Ser Pro 
                165                 170                 175     


Asp Arg Pro Gly Pro Asp Arg Phe Val Thr Asp Gln Gly Ala Cys Ala 
            180                 185                 190         


Gly Ser Pro Ser Leu Val Ala Ala Ala Arg Arg Ala Phe Pro Cys Lys 
        195                 200                 205             


Asp Ala Ala Leu Cys Ala Tyr Ala Val Thr Tyr Thr Ala Met Tyr Val 
    210                 215                 220                 


Thr Leu Val Phe Arg Val Lys Gly Ser Arg Leu Val Lys Pro Ser Leu 
225                 230                 235                 240 


Cys Leu Ala Leu Leu Cys Pro Ala Phe Leu Val Gly Val Val Arg Val 
                245                 250                 255     


Ala Glu Tyr Arg Asn His Trp Ser Asp Val Leu Ala Gly Phe Leu Thr 
            260                 265                 270         


Gly Ala Ala Ile Ala Thr Phe Leu Val Thr Cys Val Val His Asn Phe 
        275                 280                 285             


Gln Ser Arg Pro Pro Ser Gly Arg Arg Leu Ser Pro Trp Glu Asp Leu 
    290                 295                 300                 


Gly Gln Ala Pro Thr Met Asp Ser Pro Leu Glu Lys Asn Pro Arg Ser 
305                 310                 315                 320 


Ala Gly Arg Ile Arg His Arg His Gly Ser Pro His Pro Ser Arg Arg 
                325                 330                 335     


Thr Ala Pro Ala Val Ala Thr 
            340             


<210>  4940
<211>  1154
<212>  PRT
<213>  Homo sapiens

<400>  4940

Met Gln Ala Met Glu Gly Glu Val Leu Leu Pro Ala Leu Tyr Glu Glu 
1               5                   10                  15      


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Glu 
            20                  25                  30          


Gln Val Gln Lys Gly Gly Ser Val Gly Ser Leu Ser Val Asn Lys His 
        35                  40                  45              


Arg Gly Leu Ser Leu Thr Glu Thr Glu Leu Glu Glu Leu Arg Ala Gln 
    50                  55                  60                  


Val Leu Gln Leu Val Ala Glu Leu Glu Glu Thr Arg Glu Leu Ala Gly 
65                  70                  75                  80  


Gln His Glu Asp Asp Ser Leu Glu Leu Gln Gly Leu Leu Glu Asp Glu 
                85                  90                  95      


Arg Leu Ala Ser Ala Gln Gln Ala Glu Val Phe Thr Lys Gln Ile Gln 
            100                 105                 110         


Gln Leu Gln Gly Glu Leu Arg Ser Leu Arg Glu Glu Ile Ser Leu Leu 
        115                 120                 125             


Glu His Glu Lys Glu Ser Glu Leu Lys Glu Ile Glu Gln Glu Leu His 
    130                 135                 140                 


Leu Ala Gln Ala Glu Ile Gln Ser Leu Arg Gln Ala Ala Glu Asp Ser 
145                 150                 155                 160 


Ala Thr Glu His Glu Ser Asp Ile Ala Ser Leu Gln Glu Asp Leu Cys 
                165                 170                 175     


Arg Met Gln Asn Glu Leu Glu Asp Met Glu Arg Ile Arg Gly Asp Tyr 
            180                 185                 190         


Glu Met Glu Ile Ala Ser Leu Arg Ala Glu Met Glu Met Lys Ser Ser 
        195                 200                 205             


Glu Pro Ser Gly Ser Leu Gly Leu Ser Asp Tyr Ser Gly Leu Gln Glu 
    210                 215                 220                 


Glu Leu Gln Glu Leu Arg Glu Arg Tyr His Phe Leu Asn Glu Glu Tyr 
225                 230                 235                 240 


Arg Ala Leu Gln Glu Ser Asn Ser Ser Leu Thr Gly Gln Leu Ala Asp 
                245                 250                 255     


Leu Glu Ser Glu Arg Thr Gln Arg Ala Thr Glu Arg Trp Leu Gln Ser 
            260                 265                 270         


Gln Thr Leu Ser Met Thr Ser Ala Glu Ser Gln Thr Ser Glu Met Asp 
        275                 280                 285             


Phe Leu Glu Pro Asp Pro Glu Met Gln Leu Leu Arg Gln Gln Leu Arg 
    290                 295                 300                 


Asp Ala Glu Glu Gln Met His Gly Met Lys Asn Lys Cys Gln Glu Leu 
305                 310                 315                 320 


Cys Cys Glu Leu Glu Glu Leu Gln His His Arg Gln Val Ser Glu Glu 
                325                 330                 335     


Glu Gln Arg Arg Leu Gln Arg Glu Leu Lys Cys Ala Gln Asn Glu Val 
            340                 345                 350         


Leu Arg Phe Gln Thr Ser His Ser Val Thr Gln Asn Glu Glu Leu Lys 
        355                 360                 365             


Ser Arg Leu Cys Thr Leu Gln Lys Lys Tyr Asp Thr Ser Gln Asp Glu 
    370                 375                 380                 


Gln Asn Glu Leu Leu Lys Met Gln Leu Gln Leu Gln Thr Glu Leu Arg 
385                 390                 395                 400 


Gln Leu Lys Val Met Lys Ser Thr Leu Val Glu Asn Gln Ser Glu Lys 
                405                 410                 415     


Glu Leu Leu Cys Arg Leu Gln Lys Leu His Leu Gln His Gln Asn Val 
            420                 425                 430         


Thr Cys Glu Lys Glu Lys Leu Leu Glu Arg Gln Gln Gln Leu Gln Glu 
        435                 440                 445             


Glu Leu Gln Cys His Glu Ala Glu Leu Gln His Leu Arg Asp Thr Val 
    450                 455                 460                 


Ala Ser Phe Lys Glu Ser Asn Glu Lys Asp Thr Glu Thr His Ala Gln 
465                 470                 475                 480 


Leu Gln Glu Met Lys Gln Leu Tyr Gln Ala Ser Lys Asp Glu Leu Glu 
                485                 490                 495     


Arg Gln Lys His Met Tyr Asp Gln Leu Glu Gln Asp Leu Leu Leu Cys 
            500                 505                 510         


Gln Leu Glu Leu Lys Glu Leu Lys Ala Ser His Pro Ile Pro Glu Asp 
        515                 520                 525             


Lys Gly Lys Cys Ala Asn Lys Cys Asp Thr Leu Leu Ser Arg Leu Thr 
    530                 535                 540                 


Glu Leu Gln Glu Lys Tyr Lys Ala Ser Gln Lys Glu Met Gly Gln Leu 
545                 550                 555                 560 


Gln Met Glu Gln Cys Glu Leu Leu Glu Asp Gln Arg Arg Met Gln Glu 
                565                 570                 575     


Glu Gln Gly Gln Leu Gln Glu Glu Leu His Arg Leu Thr Leu Pro Leu 
            580                 585                 590         


Pro Lys Ser Gly Leu Leu Leu Lys Ser Gln Glu Leu Leu Thr Lys Leu 
        595                 600                 605             


Glu Asp Leu Cys Glu Leu Gln Leu Leu Tyr Gln Gly Met Gln Glu Glu 
    610                 615                 620                 


Gln Lys Lys Leu Ile Gln Asn Gln Asp Cys Val Leu Lys Glu Gln Leu 
625                 630                 635                 640 


Glu Ile His Glu Glu Leu Arg Arg Phe Lys Glu Ser His Phe Gln Glu 
                645                 650                 655     


Val Leu Glu Asn Pro Asp Asp Ser Lys Leu Ala Lys Ser Ser Lys Cys 
            660                 665                 670         


Asn Arg Asn Lys Gln Ser Lys Leu Leu Met Glu Gln Met Gln Ala Leu 
        675                 680                 685             


Gln Val Met Tyr Asp Ala Gly Gln Ala Lys Gln Glu Leu Leu Gln Gln 
    690                 695                 700                 


Glu Gln Gly Arg Leu Leu Glu Glu Arg Lys Arg Leu Gln Ala Asp Leu 
705                 710                 715                 720 


Gln Leu Cys Leu Glu Glu Met Gln Leu Leu Gln Val Gln Ser Pro Ser 
                725                 730                 735     


Ile Lys Met Ser Leu Glu Ser Tyr Gly Lys Ser Tyr Gly Ser Met Val 
            740                 745                 750         


Pro Ser Asn Glu Asn Cys Arg Lys Thr Tyr Asp Thr Thr Val Asp Asp 
        755                 760                 765             


Asn Glu Ser Tyr Tyr Lys Ser Tyr Thr Ser Thr Gln Thr Ser Ser Lys 
    770                 775                 780                 


Ser Phe Leu Lys Ser Tyr Asp Ser Ser Thr Ser Ala Ser Glu Ala Tyr 
785                 790                 795                 800 


Gly Lys Ser Tyr Cys Thr Thr Ser Asn Ser Ser Ile Thr Tyr Lys Lys 
                805                 810                 815     


Ser Tyr Gly Ser Thr Ser Ser Ser Asp Thr Cys Gln Lys Ser Phe Val 
            820                 825                 830         


Ser Ser Cys Thr Asp Glu Glu Pro Ala Glu Pro Glu Asp Met Glu Arg 
        835                 840                 845             


Phe Glu Glu Met Val Val Lys Val Leu Ile Lys Leu Gln Ala Val Gln 
    850                 855                 860                 


Ala Met Tyr Gln Ile Ser Gln Glu Glu His Ser Gln Leu Gln Glu Gln 
865                 870                 875                 880 


Met Glu Lys Leu Leu Ala Lys Gln Lys Asp Leu Lys Glu Glu Leu Asp 
                885                 890                 895     


Ala Cys Glu Arg Glu Phe Lys Glu Cys Met Glu Cys Leu Glu Lys Pro 
            900                 905                 910         


Met Ala Pro Gln Asn Asp Lys Asn Glu Ile Lys Glu Leu Gln Thr Lys 
        915                 920                 925             


Leu Arg Glu Leu Gln Leu Gln Tyr Gln Ala Ser Met Asp Glu Gln Gly 
    930                 935                 940                 


Arg Leu Leu Val Val Gln Glu Gln Leu Glu Gly Gln Leu Gln Cys Cys 
945                 950                 955                 960 


Gln Glu Glu Leu Arg Gln Leu Arg Glu Lys Arg Pro Ser Val Val Lys 
                965                 970                 975     


Glu Ala Arg Gly Lys Asn Ala Asn Lys Asn Met Asn Lys Asn Ala Asn 
            980                 985                 990         


Gly Val Lys Met Lys Lys Val Thr  Lys Pro Cys Ser Asp  Thr Ser Glu 
        995                 1000                 1005             


Ser Asp  Leu Glu Thr Arg Lys  Ser Leu Glu Val Val  Leu Tyr Tyr 
    1010                 1015                 1020             


Lys Ala  Ser Gln Arg Lys Leu  Asp Gly Leu Ala Lys  Glu Glu Glu 
    1025                 1030                 1035             


Lys Lys  Glu Glu Met Glu Glu  Glu Lys Lys Glu Val  Lys Glu Glu 
    1040                 1045                 1050             


Ala Lys  Glu Gln Cys Gly Asp  Glu Leu Val Ala Glu  Pro Ala Asp 
    1055                 1060                 1065             


Pro Glu  Glu Ala Lys Ser Thr  Glu Asp Gln Glu Glu  Asn Glu Glu 
    1070                 1075                 1080             


Asp Lys  Glu Glu Glu Glu Lys  Glu Glu Asp Ser Glu  Glu Glu Glu 
    1085                 1090                 1095             


Asp Asp  Ala Asp Ser Ser Leu  Glu Ser Pro Glu Glu  Asn Asn Pro 
    1100                 1105                 1110             


Leu Arg  Leu Ser Glu Ser Lys  Lys Ser Ser Pro Thr  Pro Asn Pro 
    1115                 1120                 1125             


Pro Ile  Phe Ser Leu Pro Leu  Val Gly Leu Val Val  Ile Ser Ala 
    1130                 1135                 1140             


Leu Leu  Trp Cys Trp Trp Ala  Glu Thr Ser Ser 
    1145                 1150                 


<210>  4941
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  4941

Met Ala Asp Asp Ala Gly Leu Glu Thr Pro Leu Cys Ser Glu Gln Phe 
1               5                   10                  15      


Gly Ser Gly Glu Ala Arg Gly Cys Arg Ala Ala Ala Asp Gly Ser Leu 
            20                  25                  30          


Gln Trp Glu Val Gly Gly Trp Arg Trp Trp Gly Leu Ser Arg Ala Phe 
        35                  40                  45              


Thr Val Lys Pro Glu Gly Arg Asp Ala Gly Glu Val Gly Ala Ser Gly 
    50                  55                  60                  


Ala Pro Ser Pro Pro Leu Ser Gly Leu Gln Ala Val Phe Leu Pro Gln 
65                  70                  75                  80  


Gly Phe Pro Asp Ser Val Ser Pro Asp Tyr Leu Pro Tyr Gln Leu Trp 
                85                  90                  95      


Asp Ser Val Gln Ala Phe Ala Ser Ser Leu Ser Gly Ser Leu Ala Thr 
            100                 105                 110         


Gln Ala Val Leu Leu Gly Ile Gly Val Gly Asn Ala Lys Ala Thr Val 
        115                 120                 125             


Ser Ala Ala Thr Ala Thr Trp Leu Val Lys Asp Ser Thr Gly Met Leu 
    130                 135                 140                 


Gly Arg Ile Val Phe Ala Trp Trp Lys Gly Ser Lys Leu Asp Cys Asn 
145                 150                 155                 160 


Ala Lys Gln Trp Arg Leu Phe Ala Asp Ile Leu Asn Asp Val Ala Met 
                165                 170                 175     


Phe Leu Glu Ile Met Ala Pro Val Tyr Pro Ile Cys Phe Thr Met Thr 
            180                 185                 190         


Val Ser Thr Ser Asn Leu Ala Lys Cys Ile Val Ser Val Ala Gly Gly 
        195                 200                 205             


Ala Thr Arg Ala Ala Leu Thr Val His Gln Ala Arg Arg Asn Asn Met 
    210                 215                 220                 


Ala Asp Val Ser Ala Lys Asp Ser Ser Gln Glu Thr Leu Val Asn Leu 
225                 230                 235                 240 


Ala Gly Leu Leu Val Ser Leu Leu Met Leu Pro Leu Val Ser Gly Cys 
                245                 250                 255     


Pro Gly Phe Ser Leu Gly Cys Phe Phe Phe Leu Thr Ala Leu His Ile 
            260                 265                 270         


Tyr Ala Asn Tyr Arg Ala Val Arg Ala Leu Val Met Glu Thr Leu Asn 
        275                 280                 285             


Glu Gly Arg Leu Arg Leu Val Leu Lys His Tyr Leu Gln Arg Gly Glu 
    290                 295                 300                 


Val Leu Asp Pro Thr Ala Ala Asn Arg Met Glu Pro Leu Trp Thr Gly 
305                 310                 315                 320 


Phe Trp Pro Ala Pro Ser Leu Ser Leu Gly Val Pro Leu His Arg Leu 
                325                 330                 335     


Val Ser Ser Val Phe Glu Leu Gln Gln Leu Val Glu Gly His Gln Glu 
            340                 345                 350         


Ser Tyr Leu Leu Cys Trp Asp Gln Ser Gln Asn Gln Val Gln Val Val 
        355                 360                 365             


Leu Asn Gln Lys Ala Gly Pro Lys Thr Ile Leu Arg Ala Ala Thr His 
    370                 375                 380                 


Gly Leu Met Leu Gly Ala Leu Gln Gly Asp Gly Pro Leu Pro Ala Glu 
385                 390                 395                 400 


Leu Glu Glu Leu Arg Asn Arg Val Arg Ala Gly Pro Lys Lys Glu Ser 
                405                 410                 415     


Trp Val Val Val Lys Glu Thr His Glu Val Leu Asp Met Leu Phe Pro 
            420                 425                 430         


Lys Phe Leu Lys Gly Leu Gln Asp Ala Gly Trp Lys Thr Glu Lys His 
        435                 440                 445             


Gln Leu Glu Val Asp Glu Trp Arg Ala Thr Trp Leu Leu Ser Pro Glu 
    450                 455                 460                 


Lys Lys Val Leu 
465             


<210>  4942
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  4942

Met Gly Ala Ala Gly Ser Ser Ala Leu Ala Arg Phe Val Leu Leu Ala 
1               5                   10                  15      


Gln Ser Arg Pro Gly Trp Leu Gly Val Ala Ala Leu Gly Leu Thr Ala 
            20                  25                  30          


Val Ala Leu Gly Ala Val Ala Trp Arg Arg Ala Trp Pro Thr Arg Arg 
        35                  40                  45              


Arg Arg Leu Leu Gln Gln Val Gly Thr Val Ala Gln Leu Trp Ile Tyr 
    50                  55                  60                  


Pro Val Lys Ser Cys Lys Gly Val Pro Val Ser Glu Ala Glu Cys Thr 
65                  70                  75                  80  


Ala Met Gly Leu Arg Ser Gly Asn Leu Arg Asp Arg Phe Trp Leu Val 
                85                  90                  95      


Ile Asn Gln Glu Gly Asn Met Val Thr Ala Arg Gln Glu Pro Arg Leu 
            100                 105                 110         


Val Leu Ile Ser Leu Thr Cys Asp Gly Asp Thr Leu Thr Leu Ser Ala 
        115                 120                 125             


Ala Tyr Thr Lys Asp Leu Leu Leu Pro Ile Lys Thr Pro Thr Thr Asn 
    130                 135                 140                 


Ala Val His Lys Cys Arg Val His Gly Leu Glu Ile Glu Gly Arg Asp 
145                 150                 155                 160 


Cys Gly Glu Ala Thr Ala Gln Trp Ile Thr Ser Phe Leu Lys Ser Gln 
                165                 170                 175     


Pro Tyr Arg Leu Val His Phe Glu Pro His Met Arg Pro Arg Arg Pro 
            180                 185                 190         


His Gln Ile Ala Asp Leu Phe Arg Pro Lys Asp Gln Ile Ala Tyr Ser 
        195                 200                 205             


Asp Thr Ser Pro Phe Leu Ile Leu Ser Glu Ala Ser Leu Ala Asp Leu 
    210                 215                 220                 


Asn Ser Arg Leu Glu Lys Lys Val Lys Ala Thr Asn Phe Arg Pro Asn 
225                 230                 235                 240 


Ile Val Ile Ser Gly Cys Asp Val Tyr Ala Glu Asp Ser Trp Asp Glu 
                245                 250                 255     


Leu Leu Ile Gly Asp Val Glu Leu Lys Arg Val Met Ala Cys Ser Arg 
            260                 265                 270         


Cys Ile Leu Thr Thr Val Asp Pro Asp Thr Gly Val Met Ser Arg Lys 
        275                 280                 285             


Glu Pro Leu Glu Thr Leu Lys Ser Tyr Arg Gln Cys Asp Pro Ser Glu 
    290                 295                 300                 


Arg Lys Leu Tyr Gly Lys Ser Pro Leu Phe Gly Gln Tyr Phe Val Leu 
305                 310                 315                 320 


Glu Asn Pro Gly Thr Ile Lys Val Gly Asp Pro Val Tyr Leu Leu Gly 
                325                 330                 335     


Gln 
    


<210>  4943
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  4943

Met Ser Gly Glu Leu Pro Pro Asn Ile Asn Ile Lys Glu Pro Arg Trp 
1               5                   10                  15      


Asp Gln Ser Thr Phe Ile Gly Arg Ala Asn His Phe Phe Thr Val Thr 
            20                  25                  30          


Asp Pro Arg Asn Ile Leu Leu Thr Asn Glu Gln Leu Glu Ser Ala Arg 
        35                  40                  45              


Lys Ile Val His Asp Tyr Arg Gln Gly Ile Val Pro Pro Gly Leu Thr 
    50                  55                  60                  


Glu Asn Glu Leu Trp Arg Ala Lys Tyr Ile Tyr Asp Ser Ala Phe His 
65                  70                  75                  80  


Pro Asp Thr Gly Glu Lys Met Ile Leu Ile Gly Arg Met Ser Ala Gln 
                85                  90                  95      


Val Pro Met Asn Met Thr Ile Thr Gly Cys Met Met Thr Phe Tyr Arg 
            100                 105                 110         


Thr Thr Pro Ala Val Leu Phe Trp Gln Trp Ile Asn Gln Ser Phe Asn 
        115                 120                 125             


Ala Val Val Asn Tyr Thr Asn Arg Ser Gly Asp Ala Pro Leu Thr Val 
    130                 135                 140                 


Asn Glu Leu Gly Thr Ala Tyr Val Ser Ala Thr Thr Gly Ala Val Ala 
145                 150                 155                 160 


Thr Ala Leu Gly Leu Asn Ala Leu Thr Lys His Val Ser Pro Leu Ile 
                165                 170                 175     


Gly Arg Phe Val Pro Phe Ala Ala Val Ala Ala Ala Asn Cys Ile Asn 
            180                 185                 190         


Ile Pro Leu Met Arg Gln Arg Glu Leu Lys Val Gly Ile Pro Val Thr 
        195                 200                 205             


Asp Glu Asn Gly Asn Arg Leu Gly Glu Ser Ala Asn Ala Ala Lys Gln 
    210                 215                 220                 


Ala Ile Thr Gln Val Val Val Ser Arg Ile Leu Met Ala Ala Pro Gly 
225                 230                 235                 240 


Met Ala Ile Pro Pro Phe Ile Met Asn Thr Leu Glu Lys Lys Ala Phe 
                245                 250                 255     


Leu Lys Arg Phe Pro Trp Met Ser Ala Pro Ile Gln Val Gly Leu Val 
            260                 265                 270         


Gly Phe Cys Leu Val Phe Ala Thr Pro Leu Cys Cys Ala Leu Phe Pro 
        275                 280                 285             


Gln Lys Ser Ser Met Ser Val Thr Ser Leu Glu Ala Glu Leu Gln Ala 
    290                 295                 300                 


Lys Ile Gln Glu Ser His Pro Glu Leu Arg Arg Val Tyr Phe Asn Lys 
305                 310                 315                 320 


Gly Leu 
        


<210>  4944
<211>  1204
<212>  PRT
<213>  Homo sapiens

<400>  4944

Met Tyr Val Thr Met Met Met Thr Asp Gln Ile Pro Leu Glu Leu Pro 
1               5                   10                  15      


Pro Leu Leu Asn Gly Glu Val Ala Met Met Pro His Leu Val Asn Gly 
            20                  25                  30          


Asp Ala Ala Gln Gln Val Ile Leu Val Gln Val Asn Pro Gly Glu Thr 
        35                  40                  45              


Phe Thr Ile Arg Ala Glu Asp Gly Thr Leu Gln Cys Ile Gln Gly Pro 
    50                  55                  60                  


Ala Glu Val Pro Met Met Ser Pro Asn Gly Ser Ile Pro Pro Ile His 
65                  70                  75                  80  


Val Pro Pro Gly Tyr Ile Ser Gln Val Ile Glu Asp Ser Thr Gly Val 
                85                  90                  95      


Arg Arg Val Val Val Thr Pro Gln Ser Pro Glu Cys Tyr Pro Pro Ser 
            100                 105                 110         


Tyr Pro Ser Ala Met Ser Pro Thr His His Leu Pro Pro Tyr Leu Thr 
        115                 120                 125             


His His Pro His Phe Ile His Asn Ser His Thr Ala Tyr Tyr Pro Pro 
    130                 135                 140                 


Val Thr Gly Pro Gly Asp Met Pro Pro Gln Phe Phe Pro Gln His His 
145                 150                 155                 160 


Leu Pro His Thr Ile Tyr Gly Glu Gln Glu Ile Ile Pro Phe Tyr Gly 
                165                 170                 175     


Met Ser Thr Tyr Ile Thr Arg Glu Asp Gln Tyr Ser Lys Pro Pro His 
            180                 185                 190         


Lys Lys Leu Lys Asp Arg Gln Ile Asp Arg Gln Asn Arg Leu Asn Ser 
        195                 200                 205             


Pro Pro Ser Ser Ile Tyr Lys Ser Ser Cys Thr Thr Val Tyr Asn Gly 
    210                 215                 220                 


Tyr Gly Lys Gly His Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser 
225                 230                 235                 240 


Gly Pro Gly Ile Lys Lys Thr Glu Arg Arg Ala Arg Ser Ser Pro Lys 
                245                 250                 255     


Ser Asn Asp Ser Asp Leu Gln Glu Tyr Glu Leu Glu Val Lys Arg Val 
            260                 265                 270         


Gln Asp Ile Leu Ser Gly Ile Glu Lys Pro Gln Val Ser Asn Ile Gln 
        275                 280                 285             


Ala Arg Ala Val Val Leu Ser Trp Ala Pro Pro Val Gly Leu Ser Cys 
    290                 295                 300                 


Gly Pro His Ser Gly Leu Ser Phe Pro Tyr Ser Tyr Glu Val Ala Leu 
305                 310                 315                 320 


Ser Asp Lys Gly Arg Asp Gly Lys Tyr Lys Ile Ile Tyr Ser Gly Glu 
                325                 330                 335     


Glu Leu Glu Cys Asn Leu Lys Asp Leu Arg Pro Ala Thr Asp Tyr His 
            340                 345                 350         


Val Arg Val Tyr Ala Met Tyr Asn Ser Val Lys Gly Ser Cys Ser Glu 
        355                 360                 365             


Pro Val Ser Phe Thr Thr His Ser Cys Ala Pro Glu Cys Pro Phe Pro 
    370                 375                 380                 


Pro Lys Leu Ala His Arg Ser Lys Ser Ser Leu Thr Leu Gln Trp Lys 
385                 390                 395                 400 


Ala Pro Ile Asp Asn Gly Ser Lys Ile Thr Asn Tyr Leu Leu Glu Trp 
                405                 410                 415     


Asp Glu Gly Lys Arg Asn Ser Gly Phe Arg Gln Cys Phe Phe Gly Ser 
            420                 425                 430         


Gln Lys His Cys Lys Leu Thr Lys Leu Cys Pro Ala Met Gly Tyr Thr 
        435                 440                 445             


Phe Arg Leu Ala Ala Arg Asn Asp Ile Gly Thr Ser Gly Tyr Ser Gln 
    450                 455                 460                 


Glu Val Val Cys Tyr Thr Leu Gly Asn Ile Pro Gln Met Pro Ser Ala 
465                 470                 475                 480 


Pro Arg Leu Val Arg Ala Gly Ile Thr Trp Val Thr Leu Gln Trp Ser 
                485                 490                 495     


Lys Pro Glu Gly Cys Ser Pro Glu Glu Val Ile Thr Tyr Thr Leu Glu 
            500                 505                 510         


Ile Gln Glu Asp Glu Asn Asp Asn Leu Phe His Pro Lys Tyr Thr Gly 
        515                 520                 525             


Glu Asp Leu Thr Cys Thr Val Lys Asn Leu Lys Arg Ser Thr Gln Tyr 
    530                 535                 540                 


Lys Phe Arg Leu Thr Ala Ser Asn Thr Glu Gly Lys Ser Cys Pro Ser 
545                 550                 555                 560 


Glu Val Leu Val Cys Thr Thr Ser Pro Asp Arg Pro Gly Pro Pro Thr 
                565                 570                 575     


Arg Pro Leu Val Lys Gly Pro Val Thr Ser His Gly Phe Ser Val Lys 
            580                 585                 590         


Trp Asp Pro Pro Lys Asp Asn Gly Gly Ser Glu Ile Leu Lys Tyr Leu 
        595                 600                 605             


Leu Glu Ile Thr Asp Gly Asn Ser Glu Ala Asn Gln Trp Glu Val Ala 
    610                 615                 620                 


Tyr Ser Gly Ser Ala Thr Glu Tyr Thr Phe Thr His Leu Lys Pro Gly 
625                 630                 635                 640 


Thr Leu Tyr Lys Leu Arg Ala Cys Cys Ile Ser Thr Gly Gly His Ser 
                645                 650                 655     


Gln Cys Ser Glu Ser Leu Pro Val Arg Thr Leu Ser Ile Ala Pro Gly 
            660                 665                 670         


Gln Cys Arg Pro Pro Arg Val Leu Gly Arg Pro Lys His Lys Glu Val 
        675                 680                 685             


His Leu Glu Trp Asp Val Pro Ala Ser Glu Ser Gly Cys Glu Val Ser 
    690                 695                 700                 


Glu Tyr Ser Val Glu Met Thr Glu Pro Glu Asp Val Ala Ser Glu Val 
705                 710                 715                 720 


Tyr His Gly Pro Glu Leu Glu Cys Thr Val Gly Asn Leu Leu Pro Gly 
                725                 730                 735     


Thr Val Tyr Arg Phe Arg Val Arg Ala Leu Asn Asp Gly Gly Tyr Gly 
            740                 745                 750         


Pro Tyr Ser Asp Val Ser Glu Ile Thr Thr Ala Ala Gly Pro Pro Gly 
        755                 760                 765             


Gln Cys Lys Ala Pro Cys Ile Ser Cys Thr Pro Asp Gly Cys Val Leu 
    770                 775                 780                 


Val Gly Trp Glu Ser Pro Asp Ser Ser Gly Ala Asp Ile Ser Glu Tyr 
785                 790                 795                 800 


Arg Leu Glu Trp Gly Glu Asp Glu Glu Ser Leu Glu Leu Ile Tyr His 
                805                 810                 815     


Gly Thr Asp Thr Arg Phe Glu Ile Arg Asp Leu Leu Pro Ala Ala Gln 
            820                 825                 830         


Tyr Cys Cys Arg Leu Gln Ala Phe Asn Gln Ala Gly Ala Gly Pro Tyr 
        835                 840                 845             


Ser Glu Leu Val Leu Cys Gln Thr Pro Ala Ser Ala Pro Asp Pro Val 
    850                 855                 860                 


Ser Thr Leu Cys Val Leu Glu Glu Glu Pro Leu Asp Ala Tyr Pro Asp 
865                 870                 875                 880 


Ser Pro Ser Ala Cys Leu Val Leu Asn Trp Glu Glu Pro Cys Asn Asn 
                885                 890                 895     


Gly Ser Glu Ile Leu Ala Tyr Thr Ile Asp Leu Gly Asp Thr Ser Ile 
            900                 905                 910         


Thr Val Gly Asn Thr Thr Met His Val Met Lys Asp Leu Leu Pro Glu 
        915                 920                 925             


Thr Thr Tyr Arg Ile Arg Ile Gln Ala Ile Asn Glu Ile Gly Ala Gly 
    930                 935                 940                 


Pro Phe Ser Gln Phe Ile Lys Ala Lys Thr Arg Pro Leu Pro Pro Leu 
945                 950                 955                 960 


Pro Pro Arg Leu Glu Cys Ala Ala Ala Gly Pro Gln Ser Leu Lys Leu 
                965                 970                 975     


Lys Trp Gly Asp Ser Asn Ser Lys Thr His Ala Ala Glu Asp Ile Val 
            980                 985                 990         


Tyr Thr Leu Gln Leu Glu Asp Arg  Asn Lys Arg Phe Ile  Ser Ile Tyr 
        995                 1000                 1005             


Arg Gly  Pro Ser His Thr Tyr  Lys Val Gln Arg Leu  Thr Glu Phe 
    1010                 1015                 1020             


Thr Cys  Tyr Ser Phe Arg Ile  Gln Ala Ala Ser Glu  Ala Gly Glu 
    1025                 1030                 1035             


Gly Pro  Phe Ser Glu Thr Tyr  Thr Phe Ser Thr Thr  Lys Ser Val 
    1040                 1045                 1050             


Pro Pro  Thr Ile Lys Ala Pro  Arg Val Thr Gln Leu  Glu Gly Asn 
    1055                 1060                 1065             


Ser Cys  Glu Ile Leu Trp Glu  Thr Val Pro Ser Met  Lys Gly Asp 
    1070                 1075                 1080             


Pro Val  Asn Tyr Ile Leu Gln  Val Leu Val Gly Arg  Glu Ser Glu 
    1085                 1090                 1095             


Tyr Lys  Gln Val Tyr Lys Gly  Glu Glu Ala Thr Phe  Gln Ile Ser 
    1100                 1105                 1110             


Gly Leu  Gln Thr Asn Thr Asp  Tyr Arg Phe Arg Val  Cys Ala Cys 
    1115                 1120                 1125             


Arg Arg  Cys Leu Asp Thr Ser  Gln Glu Leu Ser Gly  Ala Phe Ser 
    1130                 1135                 1140             


Pro Ser  Ala Ala Phe Val Leu  Gln Arg Ser Glu Val  Met Leu Thr 
    1145                 1150                 1155             


Gly Asp  Met Gly Ser Leu Asp  Asp Pro Lys Met Lys  Ser Met Met 
    1160                 1165                 1170             


Pro Thr  Asp Glu Gln Phe Ala  Ala Ile Ile Val Leu  Gly Phe Ala 
    1175                 1180                 1185             


Thr Leu  Ser Ile Leu Phe Ala  Phe Ile Leu Gln Tyr  Phe Leu Met 
    1190                 1195                 1200             


Lys 
    


<210>  4945
<211>  567
<212>  PRT
<213>  Homo sapiens

<400>  4945

Met Arg Pro Asp Ser Pro Thr Met Ala Ala Pro Ala Glu Ser Leu Arg 
1               5                   10                  15      


Arg Arg Lys Thr Gly Tyr Ser Asp Pro Glu Pro Glu Ser Pro Pro Ala 
            20                  25                  30          


Pro Gly Arg Gly Pro Ala Gly Ser Pro Ala His Leu His Thr Gly Thr 
        35                  40                  45              


Phe Trp Leu Thr Arg Ile Val Leu Leu Lys Ala Leu Ala Phe Val Tyr 
    50                  55                  60                  


Phe Val Ala Phe Leu Val Ala Phe His Gln Asn Lys Gln Leu Ile Gly 
65                  70                  75                  80  


Asp Arg Gly Leu Leu Pro Cys Arg Val Phe Leu Lys Asn Phe Gln Gln 
                85                  90                  95      


Tyr Phe Gln Asp Arg Thr Ser Trp Glu Val Phe Ser Tyr Met Pro Thr 
            100                 105                 110         


Ile Leu Trp Leu Met Asp Trp Ser Asp Met Asn Ser Asn Leu Asp Leu 
        115                 120                 125             


Leu Ala Leu Leu Gly Leu Gly Ile Ser Ser Phe Val Leu Ile Thr Gly 
    130                 135                 140                 


Cys Ala Asn Met Leu Leu Met Ala Ala Leu Trp Gly Leu Tyr Met Ser 
145                 150                 155                 160 


Leu Val Asn Val Gly His Val Trp Tyr Ser Phe Gly Trp Glu Ser Gln 
                165                 170                 175     


Leu Leu Glu Thr Gly Phe Leu Gly Ile Phe Leu Cys Pro Leu Trp Thr 
            180                 185                 190         


Leu Ser Arg Leu Pro Gln His Thr Pro Thr Ser Arg Ile Val Leu Trp 
        195                 200                 205             


Gly Phe Arg Trp Leu Ile Phe Arg Ile Met Leu Gly Ala Gly Leu Ile 
    210                 215                 220                 


Lys Ile Arg Gly Asp Arg Cys Trp Arg Asp Leu Thr Cys Met Asp Phe 
225                 230                 235                 240 


His Tyr Glu Thr Gln Pro Met Pro Asn Pro Val Ala Tyr Tyr Leu His 
                245                 250                 255     


His Ser Pro Trp Trp Phe His Arg Phe Glu Thr Leu Ser Asn His Phe 
            260                 265                 270         


Ile Glu Leu Leu Val Pro Phe Phe Leu Phe Leu Gly Arg Arg Ala Cys 
        275                 280                 285             


Ile Ile His Gly Val Leu Gln Ile Leu Phe Gln Ala Val Leu Ile Val 
    290                 295                 300                 


Ser Gly Asn Leu Ser Phe Leu Asn Trp Leu Thr Met Val Pro Ser Leu 
305                 310                 315                 320 


Ala Cys Phe Asp Asp Ala Thr Leu Gly Phe Leu Phe Pro Ser Gly Pro 
                325                 330                 335     


Gly Ser Leu Lys Asp Arg Val Leu Gln Met Gln Arg Asp Ile Arg Gly 
            340                 345                 350         


Ala Arg Pro Glu Pro Arg Phe Gly Ser Val Val Arg Arg Ala Ala Asn 
        355                 360                 365             


Val Ser Leu Gly Val Leu Leu Ala Trp Leu Ser Val Pro Val Val Leu 
    370                 375                 380                 


Asn Leu Leu Ser Ser Arg Gln Val Met Asn Thr His Phe Asn Ser Leu 
385                 390                 395                 400 


His Ile Val Asn Thr Tyr Gly Ala Phe Gly Ser Ile Thr Lys Glu Arg 
                405                 410                 415     


Ala Glu Val Ile Leu Gln Gly Thr Ala Ser Ser Asn Ala Ser Ala Pro 
            420                 425                 430         


Asp Ala Met Trp Glu Asp Tyr Glu Phe Lys Cys Lys Pro Gly Asp Pro 
        435                 440                 445             


Ser Arg Arg Pro Cys Leu Ile Ser Pro Tyr His Tyr Arg Leu Asp Trp 
    450                 455                 460                 


Leu Met Trp Phe Ala Ala Phe Gln Thr Tyr Glu His Asn Asp Trp Ile 
465                 470                 475                 480 


Ile His Leu Ala Gly Lys Leu Leu Ala Ser Asp Ala Glu Ala Leu Ser 
                485                 490                 495     


Leu Leu Ala His Asn Pro Phe Ala Gly Arg Pro Pro Pro Arg Trp Val 
            500                 505                 510         


Arg Gly Glu His Tyr Arg Tyr Lys Phe Ser Arg Pro Gly Gly Arg His 
        515                 520                 525             


Ala Ala Glu Gly Lys Trp Trp Val Arg Lys Arg Ile Gly Ala Tyr Phe 
    530                 535                 540                 


Pro Pro Leu Ser Leu Glu Glu Leu Arg Pro Tyr Phe Arg Asp Arg Gly 
545                 550                 555                 560 


Trp Pro Leu Pro Gly Pro Leu 
                565         


<210>  4946
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  4946

Met Gln Ala Val Asp Asn Leu Thr Ser Ala Pro Gly Asn Thr Ser Leu 
1               5                   10                  15      


Cys Thr Arg Asp Tyr Lys Ile Thr Gln Val Leu Phe Pro Leu Leu Tyr 
            20                  25                  30          


Thr Val Leu Phe Phe Val Gly Leu Ile Thr Asn Gly Leu Ala Met Arg 
        35                  40                  45              


Ile Phe Phe Gln Ile Arg Ser Lys Ser Asn Phe Ile Ile Phe Leu Lys 
    50                  55                  60                  


Asn Thr Val Ile Ser Asp Leu Leu Met Ile Leu Thr Phe Pro Phe Lys 
65                  70                  75                  80  


Ile Leu Ser Asp Ala Lys Leu Gly Thr Gly Pro Leu Arg Thr Phe Val 
                85                  90                  95      


Cys Gln Val Thr Ser Val Ile Phe Tyr Phe Thr Met Tyr Ile Ser Ile 
            100                 105                 110         


Ser Phe Leu Gly Leu Ile Thr Ile Asp Arg Tyr Gln Lys Thr Thr Arg 
        115                 120                 125             


Pro Phe Lys Thr Ser Asn Pro Lys Asn Leu Leu Gly Ala Lys Ile Leu 
    130                 135                 140                 


Ser Val Val Ile Trp Ala Phe Met Phe Leu Leu Ser Leu Pro Asn Met 
145                 150                 155                 160 


Ile Leu Thr Asn Arg Gln Pro Arg Asp Lys Asn Val Lys Lys Cys Ser 
                165                 170                 175     


Phe Leu Lys Ser Glu Phe Gly Leu Val Trp His Glu Ile Val Asn Tyr 
            180                 185                 190         


Ile Cys Gln Val Ile Phe Trp Ile Asn Phe Leu Ile Val Ile Val Cys 
        195                 200                 205             


Tyr Thr Leu Ile Thr Lys Glu Leu Tyr Arg Ser Tyr Val Arg Thr Arg 
    210                 215                 220                 


Gly Val Gly Lys Val Pro Arg Lys Lys Val Asn Val Lys Val Phe Ile 
225                 230                 235                 240 


Ile Ile Ala Val Phe Phe Ile Cys Phe Val Pro Phe His Phe Ala Arg 
                245                 250                 255     


Ile Pro Tyr Thr Leu Ser Gln Thr Arg Asp Val Phe Asp Cys Thr Ala 
            260                 265                 270         


Glu Asn Thr Leu Phe Tyr Val Lys Glu Ser Thr Leu Trp Leu Thr Ser 
        275                 280                 285             


Leu Asn Ala Cys Leu Asp Pro Phe Ile Tyr Phe Phe Leu Cys Lys Ser 
    290                 295                 300                 


Phe Arg Asn Ser Leu Ile Ser Met Leu Lys Cys Pro Asn Ser Ala Thr 
305                 310                 315                 320 


Ser Leu Ser Gln Asp Asn Arg Lys Lys Glu Gln Asp Gly Gly Asp Pro 
                325                 330                 335     


Asn Glu Glu Thr Pro Met 
            340         


<210>  4947
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  4947

Met Arg Glu Arg Pro Arg Leu Gly Glu Asp Ser Ser Leu Ile Ser Leu 
1               5                   10                  15      


Phe Leu Gln Val Val Ala Phe Leu Ala Met Val Met Gly Thr His Thr 
            20                  25                  30          


Tyr Ser His Trp Pro Ser Cys Cys Pro Ser Lys Gly Gln Asp Thr Ser 
        35                  40                  45              


Glu Glu Leu Leu Arg Trp Ser Thr Val Pro Val Pro Pro Leu Glu Pro 
    50                  55                  60                  


Ala Arg Pro Asn Arg His Pro Glu Ser Cys Arg Ala Ser Glu Asp Gly 
65                  70                  75                  80  


Pro Leu Asn Ser Arg Ala Ile Ser Pro Trp Arg Tyr Glu Leu Asp Arg 
                85                  90                  95      


Asp Leu Asn Arg Leu Pro Gln Asp Leu Tyr His Ala Arg Cys Leu Cys 
            100                 105                 110         


Pro His Cys Val Ser Leu Gln Thr Gly Ser His Met Asp Pro Arg Gly 
        115                 120                 125             


Asn Ser Glu Leu Leu Tyr His Asn Gln Thr Val Phe Tyr Arg Arg Pro 
    130                 135                 140                 


Cys His Gly Glu Lys Gly Thr His Lys Gly Tyr Cys Leu Glu Arg Arg 
145                 150                 155                 160 


Leu Tyr Arg Val Ser Leu Ala Cys Val Cys Val Arg Pro Arg Val Met 
                165                 170                 175     


Gly 
    


<210>  4948
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  4948

Met Asp Leu Ile Pro Asn Phe Ala Met Glu Thr Trp Val Leu Val Ala 
1               5                   10                  15      


Thr Ser Leu Val Leu Leu Tyr Ile Tyr Gly Thr His Ser His Lys Leu 
            20                  25                  30          


Phe Lys Lys Leu Gly Ile Pro Gly Pro Thr Pro Leu Pro Phe Leu Gly 
        35                  40                  45              


Thr Ile Leu Phe Tyr Leu Arg Gly Leu Trp Asn Phe Asp Arg Glu Cys 
    50                  55                  60                  


Asn Glu Lys Tyr Gly Glu Met Trp Gly Leu Tyr Glu Gly Gln Gln Pro 
65                  70                  75                  80  


Met Leu Val Ile Met Asp Pro Asp Met Ile Lys Thr Val Leu Val Lys 
                85                  90                  95      


Glu Cys Tyr Ser Val Phe Thr Asn Gln Met Pro Leu Gly Pro Met Gly 
            100                 105                 110         


Phe Leu Lys Ser Ala Leu Ser Phe Ala Glu Asp Glu Glu Trp Lys Arg 
        115                 120                 125             


Ile Arg Thr Leu Leu Ser Pro Ala Phe Thr Ser Val Lys Phe Lys Glu 
    130                 135                 140                 


Met Val Pro Ile Ile Ser Gln Cys Gly Asp Met Leu Val Arg Ser Leu 
145                 150                 155                 160 


Arg Gln Glu Ala Glu Asn Ser Lys Ser Ile Asn Leu Lys Asp Phe Phe 
                165                 170                 175     


Gly Ala Tyr Thr Met Asp Val Ile Thr Gly Thr Leu Phe Gly Val Asn 
            180                 185                 190         


Leu Asp Ser Leu Asn Asn Pro Gln Asp Pro Phe Leu Lys Asn Met Lys 
        195                 200                 205             


Lys Leu Leu Lys Leu Asp Phe Leu Asp Pro Phe Leu Leu Leu Ile Ser 
    210                 215                 220                 


Leu Phe Pro Phe Leu Thr Pro Val Phe Glu Ala Leu Asn Ile Gly Leu 
225                 230                 235                 240 


Phe Pro Lys Asp Val Thr His Phe Leu Lys Asn Ser Ile Glu Arg Met 
                245                 250                 255     


Lys Glu Ser Arg Leu Lys Asp Lys Gln Lys His Arg Val Asp Phe Phe 
            260                 265                 270         


Gln Gln Met Ile Asp Ser Gln Asn Ser Lys Glu Thr Lys Ser His Lys 
        275                 280                 285             


Ala Leu Ser Asp Leu Glu Leu Val Ala Gln Ser Ile Ile Ile Ile Phe 
    290                 295                 300                 


Ala Ala Tyr Asp Thr Thr Ser Thr Thr Leu Pro Phe Ile Met Tyr Glu 
305                 310                 315                 320 


Leu Ala Thr His Pro Asp Val Gln Gln Lys Leu Gln Glu Glu Ile Asp 
                325                 330                 335     


Ala Val Leu Pro Asn Lys Ala Pro Val Thr Tyr Asp Ala Leu Val Gln 
            340                 345                 350         


Met Glu Tyr Leu Asp Met Val Val Asn Glu Thr Leu Arg Leu Phe Pro 
        355                 360                 365             


Val Val Ser Arg Val Thr Arg Val Cys Lys Lys Asp Ile Glu Ile Asn 
    370                 375                 380                 


Gly Val Phe Ile Pro Lys Gly Leu Ala Val Met Val Pro Ile Tyr Ala 
385                 390                 395                 400 


Leu His His Asp Pro Lys Tyr Trp Thr Glu Pro Glu Lys Phe Cys Pro 
                405                 410                 415     


Glu Ser Arg Phe Ser Lys Lys Asn Lys Asp Ser Ile Asp Leu Tyr Arg 
            420                 425                 430         


Tyr Ile Pro Phe Gly Ala Gly Pro Arg Asn Cys Ile Gly Met Arg Phe 
        435                 440                 445             


Ala Leu Thr Asn Ile Lys Leu Ala Val Ile Arg Ala Leu Gln Asn Phe 
    450                 455                 460                 


Ser Phe Lys Pro Cys Lys Glu Thr Gln Ile Pro Leu Lys Leu Asp Asn 
465                 470                 475                 480 


Leu Pro Ile Leu Gln Pro Glu Lys Pro Ile Val Leu Lys Val His Leu 
                485                 490                 495     


Arg Asp Gly Ile Thr Ser Gly Pro 
            500                 


<210>  4949
<211>  279
<212>  PRT
<213>  Homo sapiens

<400>  4949

Met Glu Ala Val Val Asn Leu Tyr Gln Glu Val Met Lys His Ala Asp 
1               5                   10                  15      


Pro Arg Ile Gln Gly Tyr Pro Leu Met Gly Ser Pro Leu Leu Met Thr 
            20                  25                  30          


Ser Ile Leu Leu Thr Tyr Val Tyr Phe Val Leu Ser Leu Gly Pro Arg 
        35                  40                  45              


Ile Met Ala Asn Arg Lys Pro Phe Gln Leu Arg Gly Phe Met Ile Val 
    50                  55                  60                  


Tyr Asn Phe Ser Leu Val Ala Leu Ser Leu Tyr Ile Val Tyr Glu Phe 
65                  70                  75                  80  


Leu Met Ser Gly Trp Leu Ser Thr Tyr Thr Trp Arg Cys Asp Pro Val 
                85                  90                  95      


Asp Tyr Ser Asn Ser Pro Glu Ala Leu Arg Met Val Arg Val Ala Trp 
            100                 105                 110         


Leu Phe Leu Phe Ser Lys Phe Ile Glu Leu Met Asp Thr Val Ile Phe 
        115                 120                 125             


Ile Leu Arg Lys Lys Asp Gly Gln Val Thr Phe Leu His Val Phe His 
    130                 135                 140                 


His Ser Val Leu Pro Trp Ser Trp Trp Trp Gly Val Lys Ile Ala Pro 
145                 150                 155                 160 


Gly Gly Met Gly Ser Phe His Ala Met Ile Asn Ser Ser Val His Val 
                165                 170                 175     


Ile Met Tyr Leu Tyr Tyr Gly Leu Ser Ala Phe Gly Pro Val Ala Gln 
            180                 185                 190         


Pro Tyr Leu Trp Trp Lys Lys His Met Thr Ala Ile Gln Leu Ile Gln 
        195                 200                 205             


Phe Val Leu Val Ser Leu His Ile Ser Gln Tyr Tyr Phe Met Ser Ser 
    210                 215                 220                 


Cys Asn Tyr Gln Tyr Pro Val Ile Ile His Leu Ile Trp Met Tyr Gly 
225                 230                 235                 240 


Thr Ile Phe Phe Met Leu Phe Ser Asn Phe Trp Tyr His Ser Tyr Thr 
                245                 250                 255     


Lys Gly Lys Arg Leu Pro Arg Ala Leu Gln Gln Asn Gly Ala Pro Gly 
            260                 265                 270         


Ile Ala Lys Val Lys Ala Asn 
        275                 


<210>  4950
<211>  701
<212>  PRT
<213>  Homo sapiens

<400>  4950

Met Gly His Leu Leu Ser Lys Glu Pro Arg Asn Arg Pro Ser Gln Lys 
1               5                   10                  15      


Arg Pro Arg Cys Cys Ser Trp Cys Arg Arg Arg Arg Pro Leu Leu Arg 
            20                  25                  30          


Leu Pro Arg Arg Thr Pro Ala Lys Val Pro Pro Gln Pro Ala Ala Pro 
        35                  40                  45              


Arg Ser Arg Asp Cys Phe Phe Arg Gly Pro Cys Met Leu Cys Phe Ile 
    50                  55                  60                  


Val His Ser Pro Gly Ala Pro Ala Pro Ala Gly Pro Glu Glu Glu Pro 
65                  70                  75                  80  


Pro Leu Ser Pro Pro Pro Arg Asp Gly Ala Tyr Ala Ala Ala Ser Ser 
                85                  90                  95      


Ser Gln His Leu Ala Arg Arg Tyr Ala Ala Leu Ala Ala Glu Asp Cys 
            100                 105                 110         


Ala Ala Ala Ala Arg Arg Phe Leu Leu Ser Ser Ala Ala Ala Ala Ala 
        115                 120                 125             


Ala Ala Ala Ala Ser Ala Ser Ser Pro Ala Ser Cys Cys Lys Glu Leu 
    130                 135                 140                 


Gly Leu Ala Ala Ala Ala Ala Trp Glu Gln Gln Gly Arg Ser Leu Phe 
145                 150                 155                 160 


Leu Ala Ser Leu Gly Pro Val Arg Phe Leu Gly Pro Pro Ala Ala Val 
                165                 170                 175     


Gln Leu Phe Arg Gly Pro Thr Pro Ser Pro Ala Glu Leu Pro Thr Pro 
            180                 185                 190         


Pro Glu Met Val Cys Lys Arg Lys Gly Ala Gly Val Pro Ala Cys Thr 
        195                 200                 205             


Pro Cys Lys Gln Pro Arg Cys Gly Gly Gly Gly Cys Gly Gly Gly Gly 
    210                 215                 220                 


Gly Gly Gly Gly Gly Gly Gly Pro Ala Gly Gly Gly Ala Ser Pro Pro 
225                 230                 235                 240 


Arg Pro Pro Asp Ala Gly Cys Cys Gln Ala Pro Glu Gln Pro Pro Gln 
                245                 250                 255     


Pro Leu Cys Pro Pro Pro Ser Ser Pro Thr Ser Glu Gly Ala Pro Thr 
            260                 265                 270         


Glu Ala Gly Gly Asp Ala Val Arg Ala Gly Gly Thr Ala Pro Leu Ser 
        275                 280                 285             


Ala Gln Gln Gln His Glu Cys Gly Asp Ala Asp Cys Arg Glu Ser Pro 
    290                 295                 300                 


Glu Asn Pro Cys Asp Cys His Arg Glu Pro Pro Pro Glu Thr Pro Asp 
305                 310                 315                 320 


Ile Asn Gln Leu Pro Pro Ser Ile Leu Leu Lys Ile Phe Ser Asn Leu 
                325                 330                 335     


Ser Leu Asp Glu Arg Cys Leu Ser Ala Ser Leu Val Cys Lys Tyr Trp 
            340                 345                 350         


Arg Asp Leu Cys Leu Asp Phe Gln Phe Trp Lys Gln Leu Asp Leu Ser 
        355                 360                 365             


Ser Arg Gln Gln Val Thr Asp Glu Leu Leu Glu Lys Ile Ala Ser Arg 
    370                 375                 380                 


Ser Gln Asn Ile Ile Glu Ile Asn Ile Ser Asp Cys Arg Ser Met Ser 
385                 390                 395                 400 


Asp Asn Gly Val Cys Val Leu Ala Phe Lys Cys Pro Gly Leu Leu Arg 
                405                 410                 415     


Tyr Thr Ala Tyr Arg Cys Lys Gln Leu Ser Asp Thr Ser Ile Ile Ala 
            420                 425                 430         


Val Ala Ser His Cys Pro Leu Leu Gln Lys Val His Val Gly Asn Gln 
        435                 440                 445             


Asp Lys Leu Thr Asp Glu Gly Leu Lys Gln Leu Gly Ser Lys Cys Arg 
    450                 455                 460                 


Glu Leu Lys Asp Ile His Phe Gly Gln Cys Tyr Lys Ile Ser Asp Glu 
465                 470                 475                 480 


Gly Met Ile Val Ile Ala Lys Gly Cys Leu Lys Leu Gln Arg Ile Tyr 
                485                 490                 495     


Met Gln Glu Asn Lys Leu Val Thr Asp Gln Ser Val Lys Ala Phe Ala 
            500                 505                 510         


Glu His Cys Pro Glu Leu Gln Tyr Val Gly Phe Met Gly Cys Ser Val 
        515                 520                 525             


Thr Ser Lys Gly Val Ile His Leu Thr Lys Leu Arg Asn Leu Ser Ser 
    530                 535                 540                 


Leu Asp Leu Arg His Ile Thr Glu Leu Asp Asn Glu Thr Val Met Glu 
545                 550                 555                 560 


Ile Val Lys Arg Cys Lys Asn Leu Ser Ser Leu Asn Leu Cys Leu Asn 
                565                 570                 575     


Trp Ile Ile Asn Asp Arg Cys Val Glu Val Ile Ala Lys Glu Gly Gln 
            580                 585                 590         


Asn Leu Lys Glu Leu Tyr Leu Val Ser Cys Lys Ile Thr Asp Tyr Ala 
        595                 600                 605             


Leu Ile Ala Ile Gly Arg Tyr Ser Met Thr Ile Glu Thr Val Asp Val 
    610                 615                 620                 


Gly Trp Cys Lys Glu Ile Thr Asp Gln Gly Ala Thr Leu Ile Ala Gln 
625                 630                 635                 640 


Ser Ser Lys Ser Leu Arg Tyr Leu Gly Leu Met Arg Cys Asp Lys Val 
                645                 650                 655     


Asn Glu Val Thr Val Glu Gln Leu Val Gln Gln Tyr Pro His Ile Thr 
            660                 665                 670         


Phe Ser Thr Val Leu Gln Asp Cys Lys Arg Thr Leu Glu Arg Ala Tyr 
        675                 680                 685             


Gln Met Gly Trp Thr Pro Asn Met Ser Ala Ala Ser Ser 
    690                 695                 700     


<210>  4951
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  4951

Met Pro Ser Gly Cys His Ser Ser Pro Pro Ser Gly Leu Arg Gly Asp 
1               5                   10                  15      


Met Ala Ser Leu Val Pro Leu Ser Pro Tyr Leu Ser Pro Thr Val Leu 
            20                  25                  30          


Leu Leu Val Ser Cys Asp Leu Gly Phe Val Arg Ala Asp Arg Pro Pro 
        35                  40                  45              


Ser Pro Val Asn Val Thr Val Thr His Leu Arg Ala Asn Ser Ala Thr 
    50                  55                  60                  


Val Ser Trp Asp Val Pro Glu Gly Asn Ile Val Ile Gly Tyr Ser Ile 
65                  70                  75                  80  


Ser Gln Gln Arg Gln Asn Gly Pro Gly Gln Arg Val Ile Arg Glu Val 
                85                  90                  95      


Asn Thr Thr Thr Arg Ala Cys Ala Leu Trp Gly Leu Ala Glu Asp Ser 
            100                 105                 110         


Asp Tyr Thr Val Gln Val Arg Ser Ile Gly Leu Arg Gly Glu Ser Pro 
        115                 120                 125             


Pro Gly Pro Arg Val His Phe Arg Thr Leu Lys Gly Ser Asp Arg Leu 
    130                 135                 140                 


Pro Ser Asn Ser Ser Ser Pro Gly Asp Ile Thr Val Glu Gly Leu Asp 
145                 150                 155                 160 


Gly Glu Arg Pro Leu Gln Thr Gly Glu Val Val Ile Ile Val Val Val 
                165                 170                 175     


Leu Leu Met Trp Ala Ala Val Ile Gly Leu Phe Cys Arg Gln Tyr Asp 
            180                 185                 190         


Ile Ile Lys Asp Asn Asp Ser Asn Asn Asn Pro Lys Glu Lys Gly Lys 
        195                 200                 205             


Gly Pro Glu Gln Ser Pro Gln Gly Arg Pro Val Gly Thr Arg Gln Lys 
    210                 215                 220                 


Lys Ser Pro Ser Ile Asn Thr Ile Asp Val 
225                 230                 


<210>  4952
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  4952

Met Ala Thr Phe Ser Arg Gln Glu Phe Phe Gln Gln Leu Leu Gln Gly 
1               5                   10                  15      


Cys Leu Leu Pro Thr Ala Gln Gln Gly Leu Asp Gln Ile Trp Leu Leu 
            20                  25                  30          


Leu Ala Ile Cys Leu Ala Cys Arg Leu Leu Trp Arg Leu Gly Leu Pro 
        35                  40                  45              


Ser Tyr Leu Lys His Ala Ser Thr Val Ala Gly Gly Phe Phe Ser Leu 
    50                  55                  60                  


Tyr His Phe Phe Gln Leu His Met Val Trp Val Val Leu Leu Ser Leu 
65                  70                  75                  80  


Leu Cys Tyr Leu Val Leu Phe Leu Cys Arg His Ser Ser His Arg Gly 
                85                  90                  95      


Val Phe Leu Ser Val Thr Ile Leu Ile Tyr Leu Leu Met Gly Glu Met 
            100                 105                 110         


His Met Val Asp Thr Val Thr Trp His Lys Met Arg Gly Ala Gln Met 
        115                 120                 125             


Ile Val Ala Met Lys Ala Val Ser Leu Gly Phe Asp Leu Asp Arg Gly 
    130                 135                 140                 


Glu Val Gly Thr Val Pro Ser Pro Val Glu Phe Met Gly Tyr Leu Tyr 
145                 150                 155                 160 


Phe Val Gly Thr Ile Val Phe Gly Pro Trp Ile Ser Phe His Ser Tyr 
                165                 170                 175     


Leu Gln Ala Val Gln Gly Arg Pro Leu Ser Cys Arg Trp Leu Gln Lys 
            180                 185                 190         


Val Ala Arg Ser Leu Ala Leu Ala Leu Leu Cys Leu Val Leu Ser Thr 
        195                 200                 205             


Cys Val Gly Pro Tyr Leu Phe Pro Tyr Phe Ile Pro Leu Asn Gly Asp 
    210                 215                 220                 


Arg Leu Leu Arg Lys Trp Leu Arg Ala Tyr Glu Ser Ala Val Ser Phe 
225                 230                 235                 240 


His Phe Ser Asn Tyr Phe Val Gly Phe Leu Ser Glu Ala Thr Ala Thr 
                245                 250                 255     


Leu Ala Gly Ala Gly Phe Thr Glu Glu Lys Asp His Leu Glu Trp Asp 
            260                 265                 270         


Leu Thr Val Ser Lys Pro Leu Asn Val Glu Leu Pro Arg Ser Met Val 
        275                 280                 285             


Glu Val Val Thr Ser Trp Asn Leu Pro Met Ser Tyr Trp Leu Asn Asn 
    290                 295                 300                 


Tyr Val Phe Lys Asn Ala Leu Arg Leu Gly Thr Phe Ser Ala Val Leu 
305                 310                 315                 320 


Val Thr Tyr Ala Ala Ser Ala Leu Leu His Gly Phe Ser Phe His Leu 
                325                 330                 335     


Ala Ala Val Leu Leu Ser Leu Ala Phe Ile Thr Tyr Val Glu His Val 
            340                 345                 350         


Leu Arg Lys Arg Leu Ala Arg Ile Leu Ser Ala Cys Val Leu Ser Lys 
        355                 360                 365             


Arg Cys Pro Pro Asp Cys Ser His Gln His Arg Leu Gly Leu Gly Val 
    370                 375                 380                 


Arg Ala Leu Asn Leu Leu Phe Gly Ala Leu Ala Ile Phe His Leu Ala 
385                 390                 395                 400 


Tyr Leu Gly Ser Leu Phe Asp Val Asp Val Asp Asp Thr Thr Glu Glu 
                405                 410                 415     


Gln Gly Tyr Gly Met Ala Tyr Thr Val His Lys Trp Ser Glu Leu Ser 
            420                 425                 430         


Trp Ala Ser His Trp Val Thr Phe Gly Cys Trp Ile Phe Tyr Arg Leu 
        435                 440                 445             


Ile Gly 
    450 


<210>  4953
<211>  602
<212>  PRT
<213>  Homo sapiens

<400>  4953

Met Ala Ala Leu Ala Ala Ala Ala Lys Lys Val Trp Ser Ala Arg Arg 
1               5                   10                  15      


Leu Leu Val Leu Leu Phe Thr Pro Leu Ala Leu Leu Pro Val Val Phe 
            20                  25                  30          


Ala Leu Pro Pro Lys Glu Gly Arg Cys Leu Phe Val Ile Leu Leu Met 
        35                  40                  45              


Ala Val Tyr Trp Cys Thr Glu Ala Leu Pro Leu Ser Val Thr Ala Leu 
    50                  55                  60                  


Leu Pro Ile Val Leu Phe Pro Phe Met Gly Ile Leu Pro Ser Asn Lys 
65                  70                  75                  80  


Val Cys Pro Gln Tyr Phe Leu Asp Thr Asn Phe Leu Phe Leu Ser Gly 
                85                  90                  95      


Leu Ile Met Ala Ser Ala Ile Glu Glu Trp Asn Leu His Arg Arg Ile 
            100                 105                 110         


Ala Leu Lys Ile Leu Met Leu Val Gly Val Gln Pro Ala Arg Leu Ile 
        115                 120                 125             


Leu Gly Met Met Val Thr Thr Ser Phe Leu Ser Met Trp Leu Ser Asn 
    130                 135                 140                 


Thr Ala Ser Thr Ala Met Met Leu Pro Ile Ala Asn Ala Ile Leu Lys 
145                 150                 155                 160 


Ser Leu Phe Gly Gln Lys Glu Val Arg Lys Asp Pro Ser Gln Glu Ser 
                165                 170                 175     


Glu Glu Asn Thr Ala Ala Val Arg Arg Asn Gly Leu His Thr Val Pro 
            180                 185                 190         


Thr Glu Met Gln Phe Leu Ala Ser Thr Glu Ala Lys Asp His Pro Gly 
        195                 200                 205             


Glu Thr Glu Val Pro Leu Asp Leu Pro Ala Asp Ser Arg Lys Glu Asp 
    210                 215                 220                 


Glu Tyr Arg Arg Asn Ile Trp Lys Gly Phe Leu Ile Ser Ile Pro Tyr 
225                 230                 235                 240 


Ser Ala Ser Ile Gly Gly Thr Ala Thr Leu Thr Gly Thr Ala Pro Asn 
                245                 250                 255     


Leu Ile Leu Leu Gly Gln Leu Lys Ser Phe Phe Pro Gln Cys Asp Val 
            260                 265                 270         


Val Asn Phe Gly Ser Trp Phe Ile Phe Ala Phe Pro Leu Met Leu Leu 
        275                 280                 285             


Phe Leu Leu Ala Gly Trp Leu Trp Ile Ser Phe Leu Tyr Gly Gly Leu 
    290                 295                 300                 


Ser Phe Arg Gly Trp Arg Lys Asn Lys Ser Glu Ile Arg Thr Asn Ala 
305                 310                 315                 320 


Glu Asp Arg Ala Arg Ala Val Ile Arg Glu Glu Tyr Gln Asn Leu Gly 
                325                 330                 335     


Pro Ile Lys Phe Ala Glu Gln Ala Val Phe Ile Leu Phe Cys Met Phe 
            340                 345                 350         


Ala Ile Leu Leu Phe Thr Arg Asp Pro Lys Phe Ile Pro Gly Trp Ala 
        355                 360                 365             


Ser Leu Phe Asn Pro Gly Phe Leu Ser Asp Ala Val Thr Gly Val Ala 
    370                 375                 380                 


Ile Val Thr Ile Leu Phe Phe Phe Pro Ser Gln Arg Pro Ser Leu Lys 
385                 390                 395                 400 


Trp Trp Phe Asp Phe Lys Ala Pro Asn Thr Glu Thr Glu Pro Leu Leu 
                405                 410                 415     


Thr Trp Lys Lys Ala Gln Glu Thr Val Pro Trp Asn Ile Ile Leu Leu 
            420                 425                 430         


Leu Gly Gly Gly Phe Ala Met Ala Lys Gly Cys Glu Glu Ser Gly Leu 
        435                 440                 445             


Ser Val Trp Ile Gly Gly Gln Leu His Pro Leu Glu Asn Val Pro Pro 
    450                 455                 460                 


Ala Leu Ala Val Leu Leu Ile Thr Val Val Ile Ala Phe Phe Thr Glu 
465                 470                 475                 480 


Phe Ala Ser Asn Thr Ala Thr Ile Ile Ile Phe Leu Pro Val Leu Ala 
                485                 490                 495     


Glu Leu Ala Ile Arg Leu Arg Val His Pro Leu Tyr Leu Met Ile Pro 
            500                 505                 510         


Gly Thr Val Gly Cys Ser Phe Ala Phe Met Leu Pro Val Ser Thr Pro 
        515                 520                 525             


Pro Asn Ser Ile Ala Phe Ala Ser Gly His Leu Leu Val Lys Asp Met 
    530                 535                 540                 


Val Arg Thr Gly Leu Leu Met Asn Leu Met Gly Val Leu Leu Leu Ser 
545                 550                 555                 560 


Leu Ala Met Asn Thr Trp Ala Gln Thr Ile Phe Gln Leu Gly Thr Phe 
                565                 570                 575     


Pro Asp Trp Ala Asp Met Tyr Ser Val Asn Val Thr Ala Leu Pro Pro 
            580                 585                 590         


Thr Leu Ala Asn Asp Thr Phe Arg Thr Leu 
        595                 600         


<210>  4954
<211>  836
<212>  PRT
<213>  Homo sapiens

<400>  4954

Met Ala Gly Leu Asn Cys Gly Val Ser Ile Ala Leu Leu Gly Val Leu 
1               5                   10                  15      


Leu Leu Gly Ala Ala Arg Leu Pro Arg Gly Ala Glu Ala Phe Glu Ile 
            20                  25                  30          


Ala Leu Pro Arg Glu Ser Asn Ile Thr Val Leu Ile Lys Leu Gly Thr 
        35                  40                  45              


Pro Thr Leu Leu Ala Lys Pro Cys Tyr Ile Val Ile Ser Lys Arg His 
    50                  55                  60                  


Ile Thr Met Leu Ser Ile Lys Ser Gly Glu Arg Ile Val Phe Thr Phe 
65                  70                  75                  80  


Ser Cys Gln Ser Pro Glu Asn His Phe Val Ile Glu Ile Gln Lys Asn 
                85                  90                  95      


Ile Asp Cys Met Ser Gly Pro Cys Pro Phe Gly Glu Val Gln Leu Gln 
            100                 105                 110         


Pro Ser Thr Ser Leu Leu Pro Thr Leu Asn Arg Thr Phe Ile Trp Asp 
        115                 120                 125             


Val Lys Ala His Lys Ser Ile Gly Leu Glu Leu Gln Phe Ser Ile Pro 
    130                 135                 140                 


Arg Leu Arg Gln Ile Gly Pro Gly Glu Ser Cys Pro Asp Gly Val Thr 
145                 150                 155                 160 


His Ser Ile Ser Gly Arg Ile Asp Ala Thr Val Val Arg Ile Gly Thr 
                165                 170                 175     


Phe Cys Ser Asn Gly Thr Val Ser Arg Ile Lys Met Gln Glu Gly Val 
            180                 185                 190         


Lys Met Ala Leu His Leu Pro Trp Phe His Pro Arg Asn Val Ser Gly 
        195                 200                 205             


Phe Ser Ile Ala Asn Arg Ser Ser Ile Lys Arg Leu Cys Ile Ile Glu 
    210                 215                 220                 


Ser Val Phe Glu Gly Glu Gly Ser Ala Thr Leu Met Ser Ala Asn Tyr 
225                 230                 235                 240 


Pro Glu Gly Phe Pro Glu Asp Glu Leu Met Thr Trp Gln Phe Val Val 
                245                 250                 255     


Pro Ala His Leu Arg Ala Ser Val Ser Phe Leu Asn Phe Asn Leu Ser 
            260                 265                 270         


Asn Cys Glu Arg Lys Glu Glu Arg Val Glu Tyr Tyr Ile Pro Gly Ser 
        275                 280                 285             


Thr Thr Asn Pro Glu Val Phe Lys Leu Glu Asp Lys Gln Pro Gly Asn 
    290                 295                 300                 


Met Ala Gly Asn Phe Asn Leu Ser Leu Gln Gly Cys Asp Gln Asp Ala 
305                 310                 315                 320 


Gln Ser Pro Gly Ile Leu Arg Leu Gln Phe Gln Val Leu Val Gln His 
                325                 330                 335     


Pro Gln Asn Glu Ser Asn Lys Ile Tyr Val Val Asp Leu Ser Asn Glu 
            340                 345                 350         


Arg Ala Met Ser Leu Thr Ile Glu Pro Arg Pro Val Lys Gln Ser Arg 
        355                 360                 365             


Lys Phe Val Pro Gly Cys Phe Val Cys Leu Glu Ser Arg Thr Cys Ser 
    370                 375                 380                 


Ser Asn Leu Thr Leu Thr Ser Gly Ser Lys His Lys Ile Ser Phe Leu 
385                 390                 395                 400 


Cys Asp Asp Leu Thr Arg Leu Trp Met Asn Val Glu Lys Thr Ile Ser 
                405                 410                 415     


Cys Thr Asp His Arg Tyr Cys Gln Arg Lys Ser Tyr Ser Leu Gln Val 
            420                 425                 430         


Pro Ser Asp Ile Leu His Leu Pro Val Glu Leu His Asp Phe Ser Trp 
        435                 440                 445             


Lys Leu Leu Val Pro Lys Asp Arg Leu Ser Leu Val Leu Val Pro Ala 
    450                 455                 460                 


Gln Lys Leu Gln Gln His Thr His Glu Lys Pro Cys Asn Thr Ser Phe 
465                 470                 475                 480 


Ser Tyr Leu Val Ala Ser Ala Ile Pro Ser Gln Asp Leu Tyr Phe Gly 
                485                 490                 495     


Ser Phe Cys Pro Gly Gly Ser Ile Lys Gln Ile Gln Val Lys Gln Asn 
            500                 505                 510         


Ile Ser Val Thr Leu Arg Thr Phe Ala Pro Ser Phe Gln Gln Glu Ala 
        515                 520                 525             


Ser Arg Gln Gly Leu Thr Val Ser Phe Ile Pro Tyr Phe Lys Glu Glu 
    530                 535                 540                 


Gly Val Phe Thr Val Thr Pro Asp Thr Lys Ser Lys Val Tyr Leu Arg 
545                 550                 555                 560 


Thr Pro Asn Trp Asp Arg Gly Leu Pro Ser Leu Thr Ser Val Ser Trp 
                565                 570                 575     


Asn Ile Ser Val Pro Arg Asp Gln Val Ala Cys Leu Thr Phe Phe Lys 
            580                 585                 590         


Glu Arg Ser Gly Val Val Cys Gln Thr Gly Arg Ala Phe Met Ile Ile 
        595                 600                 605             


Gln Glu Gln Arg Thr Arg Ala Glu Glu Ile Phe Ser Leu Asp Glu Asp 
    610                 615                 620                 


Val Leu Pro Lys Pro Ser Phe His His His Ser Phe Trp Val Asn Ile 
625                 630                 635                 640 


Ser Asn Cys Ser Pro Thr Ser Gly Lys Gln Leu Asp Leu Leu Phe Ser 
                645                 650                 655     


Val Thr Leu Thr Pro Arg Thr Val Asp Leu Thr Val Ile Leu Ile Ala 
            660                 665                 670         


Ala Val Gly Gly Gly Val Leu Leu Leu Ser Ala Leu Gly Leu Ile Ile 
        675                 680                 685             


Cys Cys Val Lys Lys Lys Lys Lys Lys Thr Asn Lys Gly Pro Ala Val 
    690                 695                 700                 


Gly Ile Tyr Asn Asp Asn Ile Asn Thr Glu Met Pro Arg Gln Pro Lys 
705                 710                 715                 720 


Lys Phe Gln Lys Gly Arg Lys Asp Asn Asp Ser His Val Tyr Ala Val 
                725                 730                 735     


Ile Glu Asp Thr Met Val Tyr Gly His Leu Leu Gln Asp Ser Ser Gly 
            740                 745                 750         


Ser Phe Leu Gln Pro Glu Val Asp Thr Tyr Arg Pro Phe Gln Gly Thr 
        755                 760                 765             


Met Gly Val Cys Pro Pro Ser Pro Pro Thr Ile Cys Ser Arg Ala Pro 
    770                 775                 780                 


Thr Ala Lys Leu Ala Thr Glu Glu Pro Pro Pro Arg Ser Pro Pro Glu 
785                 790                 795                 800 


Ser Glu Ser Glu Pro Tyr Thr Phe Ser His Pro Asn Asn Gly Asp Val 
                805                 810                 815     


Ser Ser Lys Asp Thr Asp Ile Pro Leu Leu Asn Thr Gln Glu Pro Met 
            820                 825                 830         


Glu Pro Ala Glu 
        835     


<210>  4955
<211>  951
<212>  PRT
<213>  Homo sapiens

<400>  4955

Met Arg Gly Arg Gly Asn Ala Arg Ser Ser Gln Ala Leu Gly Val Ser 
1               5                   10                  15      


Trp Cys Pro Ala Thr Trp His Pro Arg Leu Asp Met Gly Arg Leu His 
            20                  25                  30          


Arg Pro Arg Ser Ser Thr Ser Tyr Arg Asn Leu Pro His Leu Phe Leu 
        35                  40                  45              


Phe Phe Leu Phe Val Gly Pro Phe Ser Cys Leu Gly Ser Tyr Ser Arg 
    50                  55                  60                  


Ala Thr Glu Leu Leu Tyr Ser Leu Asn Glu Gly Leu Pro Ala Gly Val 
65                  70                  75                  80  


Leu Ile Gly Ser Leu Ala Glu Asp Leu Arg Leu Leu Pro Arg Ser Ala 
                85                  90                  95      


Gly Arg Pro Asp Pro Gln Ser Gln Leu Pro Glu Arg Thr Gly Ala Glu 
            100                 105                 110         


Trp Asn Pro Pro Leu Ser Phe Ser Leu Ala Ser Arg Gly Leu Ser Gly 
        115                 120                 125             


Gln Tyr Val Thr Leu Asp Asn Arg Ser Gly Glu Leu His Thr Ser Ala 
    130                 135                 140                 


Gln Glu Ile Asp Arg Glu Ala Leu Cys Val Glu Gly Gly Gly Gly Thr 
145                 150                 155                 160 


Ala Trp Ser Gly Ser Val Ser Ile Ser Ser Ser Pro Ser Asp Ser Cys 
                165                 170                 175     


Leu Leu Leu Leu Asp Val Leu Val Leu Pro Gln Glu Tyr Phe Arg Phe 
            180                 185                 190         


Val Lys Val Lys Ile Ala Ile Arg Asp Ile Asn Asp Asn Ala Pro Gln 
        195                 200                 205             


Phe Pro Val Ser Gln Ile Ser Val Trp Val Pro Glu Asn Ala Pro Val 
    210                 215                 220                 


Asn Thr Arg Leu Ala Ile Glu His Pro Ala Val Asp Pro Asp Val Gly 
225                 230                 235                 240 


Ile Asn Gly Val Gln Thr Tyr Arg Leu Leu Asp Tyr His Gly Met Phe 
                245                 250                 255     


Thr Leu Asp Val Glu Glu Asn Glu Asn Gly Glu Arg Thr Pro Tyr Leu 
            260                 265                 270         


Ile Val Met Gly Ala Leu Asp Arg Glu Thr Gln Asp Gln Tyr Val Ser 
        275                 280                 285             


Ile Ile Ile Ala Glu Asp Gly Gly Ser Pro Pro Leu Leu Gly Ser Ala 
    290                 295                 300                 


Thr Leu Thr Ile Gly Ile Ser Asp Ile Asn Asp Asn Cys Pro Leu Phe 
305                 310                 315                 320 


Thr Asp Ser Gln Ile Asn Val Thr Val Tyr Gly Asn Ala Thr Val Gly 
                325                 330                 335     


Thr Pro Ile Ala Ala Val Gln Ala Val Asp Lys Asp Leu Gly Thr Asn 
            340                 345                 350         


Ala Gln Ile Thr Tyr Ser Tyr Ser Gln Lys Val Pro Gln Ala Ser Lys 
        355                 360                 365             


Asp Leu Phe His Leu Asp Glu Asn Thr Gly Val Ile Lys Leu Phe Ser 
    370                 375                 380                 


Lys Ile Gly Gly Ser Val Leu Glu Ser His Lys Leu Thr Ile Leu Ala 
385                 390                 395                 400 


Asn Gly Pro Gly Cys Ile Pro Ala Val Ile Thr Ala Leu Val Ser Ile 
                405                 410                 415     


Ile Lys Val Ile Phe Arg Pro Pro Glu Ile Val Pro Arg Tyr Ile Ala 
            420                 425                 430         


Asn Glu Ile Asp Gly Val Val Tyr Leu Lys Glu Leu Glu Pro Val Asn 
        435                 440                 445             


Thr Pro Ile Ala Phe Phe Thr Ile Arg Asp Pro Glu Gly Lys Tyr Lys 
    450                 455                 460                 


Val Asn Cys Tyr Leu Asp Gly Glu Gly Pro Phe Arg Leu Ser Pro Tyr 
465                 470                 475                 480 


Lys Pro Tyr Asn Asn Glu Tyr Leu Leu Glu Thr Thr Lys Pro Met Asp 
                485                 490                 495     


Tyr Glu Leu Gln Gln Phe Tyr Glu Val Ala Val Val Ala Trp Asn Ser 
            500                 505                 510         


Glu Gly Phe His Val Lys Arg Val Ile Lys Val Gln Leu Leu Asp Asp 
        515                 520                 525             


Asn Asp Asn Ala Pro Ile Phe Leu Gln Pro Leu Ile Glu Leu Thr Ile 
    530                 535                 540                 


Glu Glu Asn Asn Ser Pro Asn Ala Phe Leu Thr Lys Leu Tyr Ala Thr 
545                 550                 555                 560 


Asp Ala Asp Ser Glu Glu Arg Gly Gln Val Ser Tyr Phe Leu Gly Pro 
                565                 570                 575     


Asp Ala Pro Ser Tyr Phe Ser Leu Asp Ser Val Thr Gly Ile Leu Thr 
            580                 585                 590         


Val Ser Thr Gln Leu Asp Arg Glu Glu Lys Glu Lys Tyr Arg Tyr Thr 
        595                 600                 605             


Val Arg Ala Val Asp Cys Gly Lys Pro Pro Arg Glu Ser Val Ala Thr 
    610                 615                 620                 


Val Ala Leu Thr Val Leu Asp Lys Asn Asp Asn Ser Pro Arg Phe Ile 
625                 630                 635                 640 


Asn Lys Asp Phe Ser Phe Phe Val Pro Glu Asn Phe Pro Gly Tyr Gly 
                645                 650                 655     


Glu Ile Gly Val Ile Ser Val Thr Asp Ala Asp Ala Gly Arg Asn Gly 
            660                 665                 670         


Trp Val Ala Leu Ser Val Val Asn Gln Ser Asp Ile Phe Val Ile Asp 
        675                 680                 685             


Thr Gly Lys Gly Met Leu Arg Ala Lys Val Ser Leu Asp Arg Glu Gln 
    690                 695                 700                 


Gln Ser Ser Tyr Thr Leu Trp Val Glu Ala Val Asp Gly Gly Glu Pro 
705                 710                 715                 720 


Ala Leu Ser Ser Thr Ala Lys Ile Thr Ile Leu Leu Leu Asp Ile Asn 
                725                 730                 735     


Asp Asn Pro Pro Leu Val Leu Phe Pro Gln Ser Asn Met Ser Tyr Leu 
            740                 745                 750         


Leu Val Leu Pro Ser Thr Leu Pro Gly Ser Pro Val Thr Glu Val Tyr 
        755                 760                 765             


Ala Val Asp Lys Asp Thr Gly Met Asn Ala Val Ile Ala Tyr Ser Ile 
    770                 775                 780                 


Ile Gly Arg Arg Gly Pro Arg Pro Glu Ser Phe Arg Ile Asp Pro Lys 
785                 790                 795                 800 


Thr Gly Asn Ile Thr Leu Glu Glu Ala Leu Leu Gln Thr Asp Tyr Gly 
                805                 810                 815     


Leu His Arg Leu Leu Val Lys Val Ser Asp His Gly Tyr Pro Glu Pro 
            820                 825                 830         


Leu His Ser Thr Val Met Val Asn Leu Phe Val Asn Asp Thr Val Ser 
        835                 840                 845             


Asn Glu Ser Tyr Ile Glu Ser Leu Leu Arg Lys Glu Pro Glu Ile Asn 
    850                 855                 860                 


Ile Glu Glu Lys Glu Pro Gln Ile Ser Ile Glu Pro Thr His Arg Lys 
865                 870                 875                 880 


Val Glu Ser Val Ser Cys Met Pro Thr Leu Val Ala Leu Ser Val Ile 
                885                 890                 895     


Ser Leu Gly Ser Ile Thr Leu Val Thr Gly Met Gly Ile Tyr Ile Cys 
            900                 905                 910         


Leu Arg Lys Gly Glu Lys His Pro Arg Glu Asp Glu Asn Leu Glu Val 
        915                 920                 925             


Gln Ile Pro Leu Lys Gly Lys Ile Asp Leu His Met Arg Glu Arg Lys 
    930                 935                 940                 


Pro Met Asp Ile Ser Asn Ile 
945                 950     


<210>  4956
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  4956

Met Arg Gln Lys Ala Val Ser Leu Phe Leu Cys Tyr Leu Leu Leu Phe 
1               5                   10                  15      


Thr Cys Ser Gly Val Glu Ala Gly Glu Asn Ala Gly Lys Lys Lys Cys 
            20                  25                  30          


Ser Glu Ser Ser Asp Ser Gly Ser Gly Phe Trp Lys Ala Leu Thr Phe 
        35                  40                  45              


Met Ala Val Gly Gly Gly Leu Ala Val Ala Gly Leu Pro Ala Leu Gly 
    50                  55                  60                  


Phe Thr Gly Ala Gly Ile Ala Ala Asn Ser Val Ala Ala Ser Leu Met 
65                  70                  75                  80  


Ser Trp Ser Ala Ile Leu Asn Gly Gly Gly Val Pro Ala Gly Gly Leu 
                85                  90                  95      


Val Ala Thr Leu Gln Ser Leu Gly Ala Gly Gly Ser Ser Val Val Ile 
            100                 105                 110         


Gly Asn Ile Gly Ala Leu Met Gly Tyr Ala Thr His Lys Tyr Leu Asp 
        115                 120                 125             


Ser Glu Glu Asp Glu Glu 
    130                 


<210>  4957
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  4957

Met Arg Gln Lys Ala Val Ser Leu Phe Leu Cys Tyr Leu Leu Leu Phe 
1               5                   10                  15      


Thr Cys Ser Gly Val Glu Ala Gly Glu Asn Ala Gly Lys Asp Ala Gly 
            20                  25                  30          


Lys Lys Lys Cys Ser Glu Ser Ser Asp Ser Gly Ser Gly Phe Trp Lys 
        35                  40                  45              


Ala Leu Thr Phe Met Ala Val Gly Gly Gly Leu Ala Val Ala Gly Leu 
    50                  55                  60                  


Pro Ala Leu Gly Phe Thr Gly Ala Gly Ile Ala Ala Asn Ser Val Ala 
65                  70                  75                  80  


Ala Ser Leu Met Ser Trp Ser Ala Ile Leu Asn Gly Gly Gly Val Pro 
                85                  90                  95      


Ala Gly Gly Leu Val Ala Thr Leu Gln Ser Leu Gly Ala Gly Gly Ser 
            100                 105                 110         


Ser Val Val Ile Gly Asn Ile Gly Ala Leu Met Gly Tyr Ala Thr His 
        115                 120                 125             


Lys Tyr Leu Asp Ser Glu Glu Asp Glu Glu 
    130                 135             


<210>  4958
<211>  797
<212>  PRT
<213>  Homo sapiens

<400>  4958

Met Ala Ala Leu Ala Tyr Asn Leu Gly Lys Arg Glu Ile Asn His Tyr 
1               5                   10                  15      


Phe Ser Val Arg Ser Ala Lys Val Leu Ala Leu Val Ala Val Leu Leu 
            20                  25                  30          


Leu Ala Ala Cys His Leu Ala Ser Arg Arg Tyr Arg Gly Asn Asp Ser 
        35                  40                  45              


Cys Glu Tyr Leu Leu Ser Ser Gly Arg Phe Leu Gly Glu Lys Val Trp 
    50                  55                  60                  


Gln Pro His Ser Cys Met Met His Lys Tyr Lys Ile Ser Glu Ala Lys 
65                  70                  75                  80  


Asn Cys Leu Val Asp Lys His Ile Ala Phe Ile Gly Asp Ser Arg Ile 
                85                  90                  95      


Arg Gln Leu Phe Tyr Ser Phe Val Lys Ile Ile Asn Pro Gln Phe Lys 
            100                 105                 110         


Glu Glu Gly Asn Lys His Glu Asn Ile Pro Phe Glu Asp Lys Thr Ala 
        115                 120                 125             


Ser Val Lys Val Asp Phe Leu Trp His Pro Glu Val Asn Gly Ser Met 
    130                 135                 140                 


Lys Gln Cys Ile Lys Val Trp Thr Glu Asp Ser Ile Ala Lys Pro His 
145                 150                 155                 160 


Val Ile Val Ala Gly Ala Ala Thr Trp Ser Ile Lys Ile His Asn Gly 
                165                 170                 175     


Ser Ser Glu Ala Leu Ser Gln Tyr Lys Met Asn Ile Thr Ser Ile Ala 
            180                 185                 190         


Pro Leu Leu Glu Lys Leu Ala Lys Thr Ser Asp Val Tyr Trp Val Leu 
        195                 200                 205             


Gln Asp Pro Val Tyr Glu Asp Leu Leu Ser Glu Asn Arg Lys Met Ile 
    210                 215                 220                 


Thr Asn Glu Lys Ile Asp Ala Tyr Asn Glu Ala Ala Val Ser Ile Leu 
225                 230                 235                 240 


Asn Ser Ser Thr Arg Asn Ser Lys Ser Asn Val Lys Met Phe Ser Val 
                245                 250                 255     


Ser Lys Leu Ile Ala Gln Glu Thr Ile Met Glu Ser Leu Asp Gly Leu 
            260                 265                 270         


His Leu Pro Glu Ser Ser Arg Glu Thr Thr Ala Met Ile Leu Met Asn 
        275                 280                 285             


Val Tyr Cys Asn Lys Ile Leu Lys Pro Val Asp Gly Ser Cys Cys Gln 
    290                 295                 300                 


Pro Arg Pro Pro Val Thr Leu Ile Gln Lys Leu Ala Ala Cys Phe Phe 
305                 310                 315                 320 


Thr Leu Ser Ile Ile Gly Tyr Leu Ile Phe Tyr Ile Ile His Arg Asn 
                325                 330                 335     


Ala His Arg Lys Asn Lys Pro Cys Thr Asp Leu Glu Ser Gly Glu Glu 
            340                 345                 350         


Lys Lys Asn Ile Ile Asn Thr Pro Val Ser Ser Leu Glu Ile Leu Leu 
        355                 360                 365             


Gln Ser Phe Cys Lys Leu Gly Leu Ile Met Ala Tyr Phe Tyr Met Cys 
    370                 375                 380                 


Asp Arg Ala Asn Leu Phe Met Lys Glu Asn Lys Phe Tyr Thr His Ser 
385                 390                 395                 400 


Ser Phe Phe Ile Pro Ile Ile Tyr Ile Leu Val Leu Gly Val Phe Tyr 
                405                 410                 415     


Asn Glu Asn Thr Lys Glu Thr Lys Val Leu Asn Arg Glu Gln Thr Asp 
            420                 425                 430         


Glu Trp Lys Gly Trp Met Gln Leu Val Ile Leu Ile Tyr His Ile Ser 
        435                 440                 445             


Gly Ala Ser Thr Phe Leu Pro Val Tyr Met His Ile Arg Val Leu Val 
    450                 455                 460                 


Ala Ala Tyr Leu Phe Gln Thr Gly Tyr Gly His Phe Ser Tyr Phe Trp 
465                 470                 475                 480 


Ile Lys Gly Asp Phe Gly Ile Tyr Arg Val Cys Gln Val Leu Phe Arg 
                485                 490                 495     


Leu Asn Phe Leu Val Val Val Leu Cys Ile Val Met Asp Arg Pro Tyr 
            500                 505                 510         


Gln Phe Tyr Tyr Phe Val Pro Leu Val Thr Val Trp Phe Met Val Ile 
        515                 520                 525             


Tyr Val Thr Leu Ala Leu Trp Pro Gln Ile Ile Gln Lys Lys Ala Asn 
    530                 535                 540                 


Gly Asn Cys Phe Trp His Phe Gly Leu Leu Leu Lys Leu Gly Phe Leu 
545                 550                 555                 560 


Leu Leu Phe Ile Cys Phe Leu Ala Tyr Ser Gln Gly Ala Phe Glu Lys 
                565                 570                 575     


Ile Phe Ser Leu Trp Pro Leu Ser Lys Cys Phe Glu Leu Lys Gly Asn 
            580                 585                 590         


Val Tyr Glu Trp Trp Phe Arg Trp Arg Leu Asp Arg Tyr Val Val Phe 
        595                 600                 605             


His Gly Met Leu Phe Ala Phe Ile Tyr Leu Ala Leu Gln Lys Arg Gln 
    610                 615                 620                 


Ile Leu Ser Glu Gly Lys Gly Glu Pro Leu Phe Ser Asn Lys Ile Ser 
625                 630                 635                 640 


Asn Phe Leu Leu Phe Ile Ser Val Val Ser Phe Leu Thr Tyr Ser Ile 
                645                 650                 655     


Trp Ala Ser Ser Cys Lys Asn Lys Ala Glu Cys Asn Glu Leu His Pro 
            660                 665                 670         


Ser Val Ser Val Val Gln Ile Leu Ala Phe Ile Leu Ile Arg Asn Ile 
        675                 680                 685             


Pro Gly Tyr Ala Arg Ser Val Tyr Ser Ser Phe Phe Ala Trp Phe Gly 
    690                 695                 700                 


Lys Ile Ser Leu Glu Leu Phe Ile Cys Gln Tyr His Ile Trp Leu Ala 
705                 710                 715                 720 


Ala Asp Thr Arg Gly Ile Leu Val Leu Ile Pro Gly Asn Pro Met Leu 
                725                 730                 735     


Asn Ile Ile Val Ser Thr Phe Ile Phe Val Cys Val Ala His Glu Ile 
            740                 745                 750         


Ser Gln Ile Thr Asn Asp Leu Ala Gln Ile Ile Ile Pro Lys Asp Asn 
        755                 760                 765             


Ser Ser Leu Leu Lys Arg Leu Ala Cys Ile Ala Ala Phe Phe Cys Gly 
    770                 775                 780                 


Leu Leu Ile Leu Ser Ser Ile Gln Asp Lys Ser Lys His 
785                 790                 795         


<210>  4959
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  4959

Met Lys Val Thr Gly Ile Thr Ile Leu Phe Trp Pro Leu Ser Met Ile 
1               5                   10                  15      


Leu Leu Ser Asp Lys Ile Gln Ser Ser Lys Arg Glu Val Gln Cys Asn 
            20                  25                  30          


Phe Thr Glu Lys Asn Tyr Thr Leu Ile Pro Ala Asp Ile Lys Lys Asp 
        35                  40                  45              


Val Thr Ile Leu Asp Leu Ser Tyr Asn Gln Ile Thr Leu Asn Gly Thr 
    50                  55                  60                  


Asp Thr Arg Val Leu Gln Thr Tyr Phe Leu Leu Thr Glu Leu Tyr Leu 
65                  70                  75                  80  


Ile Glu Asn Lys Val Thr Ile Leu His Asn Asn Gly Phe Gly Asn Leu 
                85                  90                  95      


Ser Ser Leu Glu Ile Leu Asn Ile Cys Arg Asn Ser Ile Tyr Val Ile 
            100                 105                 110         


Gln Gln Gly Ala Phe Leu Gly Leu Asn Lys Leu Lys Gln Leu Tyr Leu 
        115                 120                 125             


Cys Gln Asn Lys Ile Glu Gln Leu Asn Ala Asp Val Phe Val Pro Leu 
    130                 135                 140                 


Arg Ser Leu Lys Leu Leu Asn Leu Gln Gly Asn Leu Ile Ser Tyr Leu 
145                 150                 155                 160 


Asp Val Pro Pro Leu Phe His Leu Glu Leu Ile Thr Leu Tyr Gly Asn 
                165                 170                 175     


Leu Trp Asn Cys Ser Cys Ser Leu Phe Asn Leu Gln Asn Trp Leu Asn 
            180                 185                 190         


Thr Ser Asn Val Thr Leu Glu Asn Glu Asn Ile Thr Met Cys Ser Tyr 
        195                 200                 205             


Pro Asn Ser Leu Gln Ser Tyr Asn Ile Lys Thr Val Pro His Lys Ala 
    210                 215                 220                 


Glu Cys His Ser Lys Phe Pro Ser Ser Val Thr Glu Asp Leu Tyr Ile 
225                 230                 235                 240 


His Phe Gln Pro Ile Ser Asn Ser Ile Phe Asn Ser Ser Ser Asn Asn 
                245                 250                 255     


Leu Thr Arg Asn Ser Glu His Glu Pro Leu Gly Lys Ser Trp Ala Phe 
            260                 265                 270         


Leu Val Gly Val Val Val Thr Val Leu Thr Thr Ser Leu Leu Ile Phe 
        275                 280                 285             


Ile Ala Ile Lys Cys Pro Ile Trp Tyr Asn Ile Leu Leu Ser Tyr Asn 
    290                 295                 300                 


His His Arg Leu Glu Glu His Glu Ala Glu Thr Tyr Glu Asp Gly Phe 
305                 310                 315                 320 


Thr Gly Asn Pro Ser Ser Leu Ser Gln Ile Pro Glu Thr Asn Ser Glu 
                325                 330                 335     


Glu Thr Thr Val Ile Phe Glu Gln Leu His Ser Phe Val Val Asp Asp 
            340                 345                 350         


Asp Gly Phe Ile Glu Asp Lys Tyr Ile Asp Ile His Glu Leu Cys Glu 
        355                 360                 365             


Glu Asn 
    370 


<210>  4960
<211>  765
<212>  PRT
<213>  Homo sapiens

<400>  4960

Met Glu Glu Lys Tyr Gly Gly Asp Val Leu Ala Gly Pro Gly Gly Gly 
1               5                   10                  15      


Gly Gly Leu Gly Pro Val Asp Val Pro Ser Ala Arg Leu Thr Lys Tyr 
            20                  25                  30          


Ile Val Leu Leu Cys Phe Thr Lys Phe Leu Lys Ala Val Gly Leu Phe 
        35                  40                  45              


Glu Ser Tyr Asp Leu Leu Lys Ala Val His Ile Val Gln Phe Ile Phe 
    50                  55                  60                  


Ile Leu Lys Leu Gly Thr Ala Phe Phe Met Val Leu Phe Gln Lys Pro 
65                  70                  75                  80  


Phe Ser Ser Gly Lys Thr Ile Thr Lys His Gln Trp Ile Lys Ile Phe 
                85                  90                  95      


Lys His Ala Val Ala Gly Cys Ile Ile Ser Leu Leu Trp Phe Phe Gly 
            100                 105                 110         


Leu Thr Leu Cys Gly Pro Leu Arg Thr Leu Leu Leu Phe Glu His Ser 
        115                 120                 125             


Asp Ile Val Val Ile Ser Leu Leu Ser Val Leu Phe Thr Ser Ser Gly 
    130                 135                 140                 


Gly Gly Pro Ala Lys Thr Arg Gly Ala Ala Phe Phe Ile Ile Ala Val 
145                 150                 155                 160 


Ile Cys Leu Leu Leu Phe Asp Asn Asp Asp Leu Met Ala Lys Met Ala 
                165                 170                 175     


Glu His Pro Glu Gly His His Asp Ser Ala Leu Thr His Met Leu Tyr 
            180                 185                 190         


Thr Ala Ile Ala Phe Leu Gly Val Ala Asp His Lys Gly Gly Val Leu 
        195                 200                 205             


Leu Leu Val Leu Ala Leu Cys Cys Lys Val Gly Phe His Thr Ala Ser 
    210                 215                 220                 


Arg Lys Leu Ser Val Asp Val Gly Gly Ala Lys Arg Leu Gln Ala Leu 
225                 230                 235                 240 


Ser His Leu Val Ser Val Leu Leu Leu Cys Pro Trp Val Ile Val Leu 
                245                 250                 255     


Ser Val Thr Thr Glu Ser Lys Val Glu Ser Trp Phe Ser Leu Ile Met 
            260                 265                 270         


Pro Phe Ala Thr Val Ile Phe Phe Val Met Ile Leu Asp Phe Tyr Val 
        275                 280                 285             


Asp Ser Ile Cys Ser Val Lys Met Glu Val Ser Lys Cys Ala Arg Tyr 
    290                 295                 300                 


Gly Ser Phe Pro Ile Phe Ile Ser Ala Leu Leu Phe Gly Asn Phe Trp 
305                 310                 315                 320 


Thr His Pro Ile Thr Asp Gln Leu Arg Ala Met Asn Lys Ala Ala His 
                325                 330                 335     


Gln Glu Ser Thr Glu His Val Leu Ser Gly Gly Val Val Val Ser Ala 
            340                 345                 350         


Ile Phe Phe Ile Leu Ser Ala Asn Ile Leu Ser Ser Pro Ser Lys Arg 
        355                 360                 365             


Gly Gln Lys Gly Thr Leu Ile Gly Tyr Ser Pro Glu Gly Thr Pro Leu 
    370                 375                 380                 


Tyr Asn Phe Met Gly Asp Ala Phe Gln His Ser Ser Gln Ser Ile Pro 
385                 390                 395                 400 


Arg Phe Ile Lys Glu Ser Leu Lys Gln Ile Leu Glu Glu Ser Asp Ser 
                405                 410                 415     


Arg Gln Ile Phe Tyr Phe Leu Cys Leu Asn Leu Leu Phe Thr Phe Val 
            420                 425                 430         


Glu Leu Phe Tyr Gly Val Leu Thr Asn Ser Leu Gly Leu Ile Ser Asp 
        435                 440                 445             


Gly Phe His Met Leu Phe Asp Cys Ser Ala Leu Val Met Gly Leu Phe 
    450                 455                 460                 


Ala Ala Leu Met Ser Arg Trp Lys Ala Thr Arg Ile Phe Ser Tyr Gly 
465                 470                 475                 480 


Tyr Gly Arg Ile Glu Ile Leu Ser Gly Phe Ile Asn Gly Leu Phe Leu 
                485                 490                 495     


Ile Val Ile Ala Phe Phe Val Phe Met Glu Ser Val Ala Arg Leu Ile 
            500                 505                 510         


Asp Pro Pro Glu Leu Asp Thr His Met Leu Thr Pro Val Ser Val Gly 
        515                 520                 525             


Gly Leu Ile Val Asn Leu Ile Gly Ile Cys Ala Phe Ser His Ala His 
    530                 535                 540                 


Ser His Ala His Gly Ala Ser Gln Gly Ser Cys His Ser Ser Asp His 
545                 550                 555                 560 


Ser His Ser His His Met His Gly His Ser Asp His Gly His Gly His 
                565                 570                 575     


Ser His Gly Ser Ala Gly Gly Gly Met Asn Ala Asn Met Arg Gly Val 
            580                 585                 590         


Phe Leu His Val Leu Ala Asp Thr Leu Gly Ser Ile Gly Val Ile Val 
        595                 600                 605             


Ser Thr Val Leu Ile Glu Gln Phe Gly Trp Phe Ile Ala Asp Pro Leu 
    610                 615                 620                 


Cys Ser Leu Phe Ile Ala Ile Leu Ile Phe Leu Ser Val Val Pro Leu 
625                 630                 635                 640 


Ile Lys Asp Ala Cys Gln Val Leu Leu Leu Arg Leu Pro Pro Glu Tyr 
                645                 650                 655     


Glu Lys Glu Leu His Ile Ala Leu Glu Lys Ile Gln Lys Ile Glu Gly 
            660                 665                 670         


Leu Ile Ser Tyr Arg Asp Pro His Phe Trp Arg His Ser Ala Ser Ile 
        675                 680                 685             


Val Ala Gly Thr Ile His Ile Gln Val Thr Ser Asp Val Leu Glu Gln 
    690                 695                 700                 


Arg Ile Val Gln Gln Val Thr Gly Ile Leu Lys Asp Ala Gly Val Asn 
705                 710                 715                 720 


Asn Leu Thr Ile Gln Val Glu Lys Glu Ala Tyr Phe Gln His Met Ser 
                725                 730                 735     


Gly Leu Ser Thr Gly Phe His Asp Val Leu Ala Met Thr Lys Gln Met 
            740                 745                 750         


Glu Ser Met Lys Tyr Cys Lys Asp Gly Thr Tyr Ile Met 
        755                 760                 765 


<210>  4961
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  4961

Met Ala Gly Leu Gln Glu Leu Arg Phe Pro Glu Glu Lys Pro Leu Leu 
1               5                   10                  15      


Arg Gly Gln Asp Ala Thr Glu Leu Glu Ser Ser Asp Ala Phe Leu Leu 
            20                  25                  30          


Ala Ala Asp Thr Asp Trp Lys Glu His Asp Ile Glu Thr Pro Tyr Gly 
        35                  40                  45              


Leu Leu His Val Val Ile Arg Gly Ser Pro Lys Gly Asn Arg Pro Ala 
    50                  55                  60                  


Ile Leu Thr Tyr His Asp Val Gly Leu Asn His Lys Leu Cys Phe Asn 
65                  70                  75                  80  


Thr Phe Phe Asn Phe Glu Asp Met Gln Glu Ile Thr Lys His Phe Val 
                85                  90                  95      


Val Cys His Val Asp Ala Pro Gly Gln Gln Val Gly Ala Ser Gln Phe 
            100                 105                 110         


Pro Gln Gly Tyr Gln Phe Pro Ser Met Glu Gln Leu Ala Ala Met Leu 
        115                 120                 125             


Pro Ser Val Val Gln His Phe Gly Phe Lys Tyr Val Ile Gly Ile Gly 
    130                 135                 140                 


Val Gly Ala Gly Ala Tyr Val Leu Ala Lys Phe Ala Leu Ile Phe Pro 
145                 150                 155                 160 


Asp Leu Val Glu Gly Leu Val Leu Val Asn Ile Asp Pro Asn Gly Lys 
                165                 170                 175     


Gly Trp Ile Asp Trp Ala Ala Thr Lys Leu Ser Gly Leu Thr Ser Thr 
            180                 185                 190         


Leu Pro Asp Thr Val Leu Ser His Leu Phe Ser Gln Glu Glu Leu Val 
        195                 200                 205             


Asn Asn Thr Glu Leu Val Gln Ser Tyr Arg Gln Gln Ile Gly Asn Val 
    210                 215                 220                 


Val Asn Gln Ala Asn Leu Gln Leu Phe Trp Asn Met Tyr Asn Ser Arg 
225                 230                 235                 240 


Arg Asp Leu Asp Ile Asn Arg Pro Gly Thr Val Pro Asn Ala Lys Thr 
                245                 250                 255     


Leu Arg Cys Pro Val Met Leu Val Val Gly Asp Asn Ala Pro Ala Glu 
            260                 265                 270         


Asp Gly Val Val Glu Cys Asn Ser Lys Leu Asp Pro Thr Thr Thr Thr 
        275                 280                 285             


Phe Leu Lys Met Ala Asp Ser Gly Gly Leu Pro Gln Val Thr Gln Pro 
    290                 295                 300                 


Gly Lys Leu Thr Glu Ala Phe Lys Tyr Phe Leu Gln Gly Met Gly Tyr 
305                 310                 315                 320 


Met Pro Ser Ala Ser Met Thr Arg Leu Ala Arg Ser Arg Thr Ala Ser 
                325                 330                 335     


Leu Thr Ser Ala Ser Ser Val Asp Gly Ser Arg Pro Gln Ala Cys Thr 
            340                 345                 350         


His Ser Glu Ser Ser Glu Gly Leu Gly Gln Val Asn His Thr Met Glu 
        355                 360                 365             


Val Ser Cys 
    370     


<210>  4962
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  4962

Met Asp Leu Arg Arg Arg Asp Tyr His Met Glu Arg Pro Leu Leu Asn 
1               5                   10                  15      


Gln Glu His Leu Glu Glu Leu Gly Arg Trp Gly Ser Ala Pro Arg Thr 
            20                  25                  30          


His Gln Trp Arg Thr Trp Leu Gln Cys Ser Arg Ala Arg Ala Tyr Ala 
        35                  40                  45              


Leu Leu Leu Gln His Leu Pro Val Leu Val Trp Leu Pro Arg Tyr Pro 
    50                  55                  60                  


Val Arg Asp Trp Leu Leu Gly Asp Leu Leu Ser Gly Leu Ser Val Ala 
65                  70                  75                  80  


Ile Met Gln Leu Pro Gln Gly Leu Ala Tyr Ala Leu Leu Ala Gly Leu 
                85                  90                  95      


Pro Pro Val Phe Gly Leu Tyr Ser Ser Phe Tyr Pro Val Phe Ile Tyr 
            100                 105                 110         


Phe Leu Phe Gly Thr Ser Arg His Ile Ser Val Gly Thr Phe Ala Val 
        115                 120                 125             


Met Ser Val Met Val Gly Ser Val Thr Glu Ser Leu Ala Pro Gln Ala 
    130                 135                 140                 


Leu Asn Asp Ser Met Ile Asn Glu Thr Ala Arg Asp Ala Ala Arg Val 
145                 150                 155                 160 


Gln Val Ala Ser Thr Leu Ser Val Leu Val Gly Leu Phe Gln Val Gly 
                165                 170                 175     


Leu Gly Leu Ile His Phe Gly Phe Val Val Thr Tyr Leu Ser Glu Pro 
            180                 185                 190         


Leu Val Arg Gly Tyr Thr Thr Ala Ala Ala Val Gln Val Phe Val Ser 
        195                 200                 205             


Gln Leu Lys Tyr Val Phe Gly Leu His Leu Ser Ser His Ser Gly Pro 
    210                 215                 220                 


Leu Ser Leu Ile Tyr Thr Val Leu Glu Val Cys Trp Lys Leu Pro Gln 
225                 230                 235                 240 


Ser Lys Val Gly Thr Val Val Thr Ala Ala Val Ala Gly Val Val Leu 
                245                 250                 255     


Val Val Val Lys Leu Leu Asn Asp Lys Leu Gln Gln Gln Leu Pro Met 
            260                 265                 270         


Pro Ile Pro Gly Glu Leu Leu Thr Leu Ile Gly Ala Thr Gly Ile Ser 
        275                 280                 285             


Tyr Gly Met Gly Leu Lys His Arg Phe Glu Val Asp Val Val Gly Asn 
    290                 295                 300                 


Ile Pro Ala Gly Leu Val Pro Pro Val Ala Pro Asn Thr Gln Leu Phe 
305                 310                 315                 320 


Ser Lys Leu Val Gly Ser Ala Phe Thr Ile Ala Val Val Gly Phe Ala 
                325                 330                 335     


Ile Ala Ile Ser Leu Gly Lys Ile Phe Ala Leu Arg His Gly Tyr Arg 
            340                 345                 350         


Val Asp Ser Asn Gln Glu Leu Val Ala Leu Gly Leu Ser Asn Leu Ile 
        355                 360                 365             


Gly Gly Ile Phe Gln Cys Phe Pro Val Ser Cys Ser Met Ser Arg Ser 
    370                 375                 380                 


Leu Val Gln Glu Ser Thr Gly Gly Asn Ser Gln Val Ala Gly Ala Ile 
385                 390                 395                 400 


Ser Ser Leu Phe Ile Leu Leu Ile Ile Val Lys Leu Gly Glu Leu Phe 
                405                 410                 415     


His Asp Leu Pro Lys Ala Val Leu Ala Ala Ile Ile Ile Val Asn Leu 
            420                 425                 430         


Lys Gly Met Leu Arg Gln Leu Ser Asp Met Arg Ser Leu Trp Lys Ala 
        435                 440                 445             


Asn Arg Ala Asp Leu Leu Ile Trp Leu Val Thr Phe Thr Ala Thr Ile 
    450                 455                 460                 


Leu Leu Asn Leu Asp Leu Gly Leu Val Val Ala Val Ile Phe Ser Leu 
465                 470                 475                 480 


Leu Leu Val Val Val Arg Thr Gln Met Pro His Tyr Ser Val Leu Gly 
                485                 490                 495     


Gln Val Pro Asp Thr Asp Ile Tyr Arg Asp Val Ala Glu Tyr Ser Glu 
            500                 505                 510         


Ala Lys Glu Val Arg Gly Val Lys Val Phe Arg Ser Ser Ala Thr Val 
        515                 520                 525             


Tyr Phe Ala Asn Ala Glu Phe Tyr Ser Asp Ala Leu Lys Gln Arg Cys 
    530                 535                 540                 


Gly Val Asp Val Asp Phe Leu Ile Ser Gln Lys Lys Lys Leu Leu Lys 
545                 550                 555                 560 


Lys Gln Glu Gln Leu Lys Leu Lys Gln Leu Gln Lys Glu Glu Lys Leu 
                565                 570                 575     


Arg Lys Gln Ala Ala Ser Pro Lys Gly Ala Ser Val Ser Ile Asn Val 
            580                 585                 590         


Asn Thr Ser Leu Glu Asp Met Arg Ser Asn Asn Val Glu Asp Cys Lys 
        595                 600                 605             


Met Met Gln Val Ser Ser Gly Asp Lys Met Glu Asp Ala Thr Ala Asn 
    610                 615                 620                 


Gly Gln Glu Asp Ser Lys Ala Pro Asp Gly Ser Thr Leu Lys Ala Leu 
625                 630                 635                 640 


Gly Leu Pro Gln Pro Asp Phe His Ser Leu Ile Leu Asp Leu Gly Ala 
                645                 650                 655     


Leu Ser Phe Val Asp Thr Val Cys Leu Lys Ser Leu Lys Asn Ile Phe 
            660                 665                 670         


His Asp Phe Arg Glu Ile Glu Val Glu Val Tyr Met Ala Ala Cys His 
        675                 680                 685             


Ser Pro Val Val Ser Gln Leu Glu Ala Gly His Phe Phe Asp Ala Ser 
    690                 695                 700                 


Ile Thr Lys Lys His Leu Phe Ala Ser Val His Asp Ala Val Thr Phe 
705                 710                 715                 720 


Ala Leu Gln His Pro Arg Pro Val Pro Asp Ser Pro Val Ser Val Thr 
                725                 730                 735     


Arg Leu 
        


<210>  4963
<211>  759
<212>  PRT
<213>  Homo sapiens

<400>  4963

Met Gly Leu Ala Asp Ala Ser Gly Pro Arg Asp Thr Gln Ala Leu Leu 
1               5                   10                  15      


Ser Ala Thr Gln Ala Met Asp Leu Arg Arg Arg Asp Tyr His Met Glu 
            20                  25                  30          


Arg Pro Leu Leu Asn Gln Glu His Leu Glu Glu Leu Gly Arg Trp Gly 
        35                  40                  45              


Ser Ala Pro Arg Thr His Gln Trp Arg Thr Trp Leu Gln Cys Ser Arg 
    50                  55                  60                  


Ala Arg Ala Tyr Ala Leu Leu Leu Gln His Leu Pro Val Leu Val Trp 
65                  70                  75                  80  


Leu Pro Arg Tyr Pro Val Arg Asp Trp Leu Leu Gly Asp Leu Leu Ser 
                85                  90                  95      


Gly Leu Ser Val Ala Ile Met Gln Leu Pro Gln Gly Leu Ala Tyr Ala 
            100                 105                 110         


Leu Leu Ala Gly Leu Pro Pro Val Phe Gly Leu Tyr Ser Ser Phe Tyr 
        115                 120                 125             


Pro Val Phe Ile Tyr Phe Leu Phe Gly Thr Ser Arg His Ile Ser Val 
    130                 135                 140                 


Gly Thr Phe Ala Val Met Ser Val Met Val Gly Ser Val Thr Glu Ser 
145                 150                 155                 160 


Leu Ala Pro Gln Ala Leu Asn Asp Ser Met Ile Asn Glu Thr Ala Arg 
                165                 170                 175     


Asp Ala Ala Arg Val Gln Val Ala Ser Thr Leu Ser Val Leu Val Gly 
            180                 185                 190         


Leu Phe Gln Val Gly Leu Gly Leu Ile His Phe Gly Phe Val Val Thr 
        195                 200                 205             


Tyr Leu Ser Glu Pro Leu Val Arg Gly Tyr Thr Thr Ala Ala Ala Val 
    210                 215                 220                 


Gln Val Phe Val Ser Gln Leu Lys Tyr Val Phe Gly Leu His Leu Ser 
225                 230                 235                 240 


Ser His Ser Gly Pro Leu Ser Leu Ile Tyr Thr Val Leu Glu Val Cys 
                245                 250                 255     


Trp Lys Leu Pro Gln Ser Lys Val Gly Thr Val Val Thr Ala Ala Val 
            260                 265                 270         


Ala Gly Val Val Leu Val Val Val Lys Leu Leu Asn Asp Lys Leu Gln 
        275                 280                 285             


Gln Gln Leu Pro Met Pro Ile Pro Gly Glu Leu Leu Thr Leu Ile Gly 
    290                 295                 300                 


Ala Thr Gly Ile Ser Tyr Gly Met Gly Leu Lys His Arg Phe Glu Val 
305                 310                 315                 320 


Asp Val Val Gly Asn Ile Pro Ala Gly Leu Val Pro Pro Val Ala Pro 
                325                 330                 335     


Asn Thr Gln Leu Phe Ser Lys Leu Val Gly Ser Ala Phe Thr Ile Ala 
            340                 345                 350         


Val Val Gly Phe Ala Ile Ala Ile Ser Leu Gly Lys Ile Phe Ala Leu 
        355                 360                 365             


Arg His Gly Tyr Arg Val Asp Ser Asn Gln Glu Leu Val Ala Leu Gly 
    370                 375                 380                 


Leu Ser Asn Leu Ile Gly Gly Ile Phe Gln Cys Phe Pro Val Ser Cys 
385                 390                 395                 400 


Ser Met Ser Arg Ser Leu Val Gln Glu Ser Thr Gly Gly Asn Ser Gln 
                405                 410                 415     


Val Ala Gly Ala Ile Ser Ser Leu Phe Ile Leu Leu Ile Ile Val Lys 
            420                 425                 430         


Leu Gly Glu Leu Phe His Asp Leu Pro Lys Ala Val Leu Ala Ala Ile 
        435                 440                 445             


Ile Ile Val Asn Leu Lys Gly Met Leu Arg Gln Leu Ser Asp Met Arg 
    450                 455                 460                 


Ser Leu Trp Lys Ala Asn Arg Ala Asp Leu Leu Ile Trp Leu Val Thr 
465                 470                 475                 480 


Phe Thr Ala Thr Ile Leu Leu Asn Leu Asp Leu Gly Leu Val Val Ala 
                485                 490                 495     


Val Ile Phe Ser Leu Leu Leu Val Val Val Arg Thr Gln Met Pro His 
            500                 505                 510         


Tyr Ser Val Leu Gly Gln Val Pro Asp Thr Asp Ile Tyr Arg Asp Val 
        515                 520                 525             


Ala Glu Tyr Ser Glu Ala Lys Glu Val Arg Gly Val Lys Val Phe Arg 
    530                 535                 540                 


Ser Ser Ala Thr Val Tyr Phe Ala Asn Ala Glu Phe Tyr Ser Asp Ala 
545                 550                 555                 560 


Leu Lys Gln Arg Cys Gly Val Asp Val Asp Phe Leu Ile Ser Gln Lys 
                565                 570                 575     


Lys Lys Leu Leu Lys Lys Gln Glu Gln Leu Lys Leu Lys Gln Leu Gln 
            580                 585                 590         


Lys Glu Glu Lys Leu Arg Lys Gln Ala Ala Ser Pro Lys Gly Ala Ser 
        595                 600                 605             


Val Ser Ile Asn Val Asn Thr Ser Leu Glu Asp Met Arg Ser Asn Asn 
    610                 615                 620                 


Val Glu Asp Cys Lys Met Met Gln Val Ser Ser Gly Asp Lys Met Glu 
625                 630                 635                 640 


Asp Ala Thr Ala Asn Gly Gln Glu Asp Ser Lys Ala Pro Asp Gly Ser 
                645                 650                 655     


Thr Leu Lys Ala Leu Gly Leu Pro Gln Pro Asp Phe His Ser Leu Ile 
            660                 665                 670         


Leu Asp Leu Gly Ala Leu Ser Phe Val Asp Thr Val Cys Leu Lys Ser 
        675                 680                 685             


Leu Lys Asn Ile Phe His Asp Phe Arg Glu Ile Glu Val Glu Val Tyr 
    690                 695                 700                 


Met Ala Ala Cys His Ser Pro Val Val Ser Gln Leu Glu Ala Gly His 
705                 710                 715                 720 


Phe Phe Asp Ala Ser Ile Thr Lys Lys His Leu Phe Ala Ser Val His 
                725                 730                 735     


Asp Ala Val Thr Phe Ala Leu Gln His Pro Arg Pro Val Pro Asp Ser 
            740                 745                 750         


Pro Val Ser Val Thr Arg Leu 
        755                 


<210>  4964
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  4964

Met Ala Ala Leu Ser Lys Ser Ile Pro His Asn Cys Tyr Glu Ile Gly 
1               5                   10                  15      


His Thr Trp His Pro Ser Cys Arg Val Ser Phe Leu Gln Ile Thr Gly 
            20                  25                  30          


Gly Ala Leu Glu Glu Ser Leu Lys Ile Tyr Ala Pro Leu Tyr Leu Ile 
        35                  40                  45              


Ala Ala Ile Leu Arg Lys Arg Lys Leu Asp Tyr Tyr Leu His Lys Leu 
    50                  55                  60                  


Leu Pro Glu Ile Leu Gln Ser Ala Ser Phe Leu Thr Ala Asn Gly Ala 
65                  70                  75                  80  


Leu Tyr Met Ala Phe Phe Cys Ile Leu Arg Lys Ile Leu Gly Lys Phe 
                85                  90                  95      


Tyr Ser Trp Thr Pro Gly Phe Gly Ala Ala Leu Pro Ala Ser Tyr Val 
            100                 105                 110         


Ala Ile Leu Ile Glu Arg Lys Ser Arg Arg Gly Leu Leu Thr Ile Tyr 
        115                 120                 125             


Met Ala Asn Leu Ala Thr Glu Thr Leu Phe Arg Met Gly Val Ala Arg 
    130                 135                 140                 


Gly Thr Ile Thr Thr Leu Arg Asn Gly Glu Val Leu Leu Phe Cys Ile 
145                 150                 155                 160 


Thr Ala Ala Met Tyr Met Phe Phe Phe Arg Cys Lys Asp Gly Leu Lys 
                165                 170                 175     


Gly Phe Thr Phe Ser Ala Leu Arg Phe Ile Val Gly Lys Glu Glu Ile 
            180                 185                 190         


Pro Thr His Ser Phe Ser Pro Glu Ala Ala Tyr Ala Lys Val Glu Gln 
        195                 200                 205             


Lys Arg Glu Gln His Glu Glu Lys Pro Gly Arg Met Asn Met Ile Gly 
    210                 215                 220                 


Leu Val Arg Lys Phe Val Asp Ser Ile Cys Lys His Gly Pro Arg His 
225                 230                 235                 240 


Arg Cys Cys Lys His Tyr Glu Asp Asn Cys Ile Ser Tyr Cys Ile Lys 
                245                 250                 255     


Gly Phe Ile Arg Met Phe Ser Val Gly Tyr Leu Ile Gln Cys Cys Leu 
            260                 265                 270         


Arg Ile Pro Ser Ala Phe Arg His Leu Phe Thr Gln Pro Ser Arg Leu 
        275                 280                 285             


Leu Ser Leu Phe Tyr Asn Lys Glu Asn Phe Gln Leu Gly Ala Phe Leu 
    290                 295                 300                 


Gly Ser Phe Val Ser Ile Tyr Lys Gly Thr Ser Cys Phe Leu Arg Trp 
305                 310                 315                 320 


Ile Arg Asn Leu Asp Asp Glu Leu His Ala Ile Ile Ala Gly Phe Leu 
                325                 330                 335     


Ala Gly Ile Ser Met Met Phe Tyr Lys Ser Thr Thr Ile Ser Met Tyr 
            340                 345                 350         


Leu Ala Ser Lys Leu Val Glu Thr Met Tyr Phe Lys Gly Ile Glu Ala 
        355                 360                 365             


Gly Lys Val Pro Tyr Phe Pro His Ala Asp Thr Ile Ile Tyr Ser Ile 
    370                 375                 380                 


Ser Thr Ala Ile Cys Phe Gln Ala Ala Val Met Glu Val Gln Thr Leu 
385                 390                 395                 400 


Arg Pro Ser Tyr Trp Lys Phe Leu Leu Arg Leu Thr Lys Gly Lys Phe 
                405                 410                 415     


Ala Val Met Asn Arg Lys Val Leu Asp Val Phe Gly Thr Gly Ala Ser 
            420                 425                 430         


Lys His Phe Gln Asp Phe Ile Pro Arg Leu Asp Pro Arg Tyr Thr Thr 
        435                 440                 445             


Val Thr Pro Glu Leu Pro Thr Glu Phe Ser 
    450                 455             


<210>  4965
<211>  762
<212>  PRT
<213>  Homo sapiens

<400>  4965

Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
1               5                   10                  15      


Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro 
            20                  25                  30          


Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala 
        35                  40                  45              


Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly 
    50                  55                  60                  


His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg 
65                  70                  75                  80  


Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala 
                85                  90                  95      


Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn 
            100                 105                 110         


Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu 
        115                 120                 125             


Asp Pro Lys Ser His Arg Asp Pro Ser Asn Arg His Ser Tyr Pro Gln 
    130                 135                 140                 


Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His 
145                 150                 155                 160 


Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly 
                165                 170                 175     


Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His 
            180                 185                 190         


Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser 
        195                 200                 205             


Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys 
    210                 215                 220                 


Leu Val Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp 
225                 230                 235                 240 


Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro 
                245                 250                 255     


Ala Asn Thr Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys 
            260                 265                 270         


Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val 
        275                 280                 285             


Ile Asn Gly Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val 
    290                 295                 300                 


Leu Lys Thr Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu 
305                 310                 315                 320 


Arg Asn Val Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                325                 330                 335     


Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro 
            340                 345                 350         


Gly Thr Gly Arg Ile Pro His Leu Thr Cys Asp Ser Leu Thr Pro Ala 
        355                 360                 365             


Gly Arg Thr Lys Ser Pro Thr Leu Gln Phe Ser Leu Glu Ser Gly Ser 
    370                 375                 380                 


Ser Gly Lys Ser Ser Ser Ser Leu Val Arg Gly Val Arg Leu Ser Ser 
385                 390                 395                 400 


Ser Gly Pro Ala Leu Leu Ala Gly Leu Val Ser Leu Asp Leu Pro Leu 
                405                 410                 415     


Asp Pro Leu Trp Glu Phe Pro Arg Asp Arg Leu Val Leu Gly Lys Pro 
            420                 425                 430         


Leu Gly Glu Gly Cys Phe Gly Gln Val Val Arg Ala Glu Ala Phe Gly 
        435                 440                 445             


Met Asp Pro Ala Arg Pro Asp Gln Ala Ser Thr Val Ala Val Lys Met 
    450                 455                 460                 


Leu Lys Asp Asn Ala Ser Asp Lys Asp Leu Ala Asp Leu Val Ser Glu 
465                 470                 475                 480 


Met Glu Val Met Lys Leu Ile Gly Arg His Lys Asn Ile Ile Asn Leu 
                485                 490                 495     


Leu Gly Val Cys Thr Gln Glu Gly Pro Leu Tyr Val Ile Val Glu Cys 
            500                 505                 510         


Ala Ala Lys Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro 
        515                 520                 525             


Gly Pro Asp Leu Ser Pro Asp Gly Pro Arg Ser Ser Glu Gly Pro Leu 
    530                 535                 540                 


Ser Phe Pro Val Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met 
545                 550                 555                 560 


Gln Tyr Leu Glu Ser Arg Lys Cys Ile His Arg Asp Leu Ala Ala Arg 
                565                 570                 575     


Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly 
            580                 585                 590         


Leu Ala Arg Gly Val His His Ile Asp Tyr Tyr Lys Lys Thr Ser Asn 
        595                 600                 605             


Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg 
    610                 615                 620                 


Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp 
625                 630                 635                 640 


Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu 
                645                 650                 655     


Glu Leu Phe Ser Leu Leu Arg Glu Gly His Arg Met Asp Arg Pro Pro 
            660                 665                 670         


His Cys Pro Pro Glu Leu Tyr Gly Leu Met Arg Glu Cys Trp His Ala 
        675                 680                 685             


Ala Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Ala Leu Asp 
    690                 695                 700                 


Lys Val Leu Leu Ala Val Ser Glu Glu Tyr Leu Asp Leu Arg Leu Thr 
705                 710                 715                 720 


Phe Gly Pro Tyr Ser Pro Ser Gly Gly Asp Ala Ser Ser Thr Cys Ser 
                725                 730                 735     


Ser Ser Asp Ser Val Phe Ser His Asp Pro Leu Pro Leu Gly Ser Ser 
            740                 745                 750         


Ser Phe Pro Phe Gly Ser Gly Val Gln Thr 
        755                 760         


<210>  4966
<211>  694
<212>  PRT
<213>  Homo sapiens

<400>  4966

Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile 
1               5                   10                  15      


Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val 
            20                  25                  30          


Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln 
        35                  40                  45              


Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro 
    50                  55                  60                  


Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly 
65                  70                  75                  80  


Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val 
                85                  90                  95      


Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg 
            100                 105                 110         


Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala 
        115                 120                 125             


Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr 
    130                 135                 140                 


Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp 
145                 150                 155                 160 


Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys 
                165                 170                 175     


Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly 
            180                 185                 190         


Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His 
        195                 200                 205             


Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly 
    210                 215                 220                 


Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr 
225                 230                 235                 240 


Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
                245                 250                 255     


Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu 
            260                 265                 270         


Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu 
        275                 280                 285             


Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro 
    290                 295                 300                 


Tyr Val Thr Val Leu Lys Val Ser Leu Glu Ser Asn Ala Ser Met Ser 
305                 310                 315                 320 


Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly 
                325                 330                 335     


Pro Thr Leu Ala Asn Val Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys 
            340                 345                 350         


Trp Glu Leu Ser Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu 
        355                 360                 365             


Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile Gly Ile Asp Lys 
    370                 375                 380                 


Asp Arg Ala Ala Lys Pro Val Thr Val Ala Val Lys Met Leu Lys Asp 
385                 390                 395                 400 


Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met 
                405                 410                 415     


Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala 
            420                 425                 430         


Cys Thr Gln Gly Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys 
        435                 440                 445             


Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp 
    450                 455                 460                 


Tyr Ser Phe Asp Thr Cys Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys 
465                 470                 475                 480 


Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu 
                485                 490                 495     


Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu 
            500                 505                 510         


Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg 
        515                 520                 525             


Asp Val His Asn Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu 
    530                 535                 540                 


Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr 
545                 550                 555                 560 


His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe 
                565                 570                 575     


Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe 
            580                 585                 590         


Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr 
        595                 600                 605             


His Asp Leu Tyr Met Ile Met Arg Glu Cys Trp His Ala Ala Pro Ser 
    610                 615                 620                 


Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Val Leu 
625                 630                 635                 640 


Thr Val Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu 
                645                 650                 655     


Gln Tyr Ser Pro Gly Gly Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly 
            660                 665                 670         


Asp Asp Ser Val Phe Ala His Asp Leu Leu Pro Pro Ala Pro Pro Ser 
        675                 680                 685             


Ser Gly Gly Ser Arg Thr 
    690                 


<210>  4967
<211>  822
<212>  PRT
<213>  Homo sapiens

<400>  4967

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              


Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu 
    50                  55                  60                  


Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
65                  70                  75                  80  


Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                85                  90                  95      


Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr 
            100                 105                 110         


Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile 
        115                 120                 125             


Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val 
    130                 135                 140                 


Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
145                 150                 155                 160 


Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys 
                165                 170                 175     


Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu 
            180                 185                 190         


Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             


Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
    210                 215                 220                 


Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile 
225                 230                 235                 240 


Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro 
                245                 250                 255     


Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly 
            260                 265                 270         


Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile 
        275                 280                 285             


Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp 
    290                 295                 300                 


Gly Leu Pro Tyr Leu Lys Val Leu Lys His Ser Gly Ile Asn Ser Ser 
305                 310                 315                 320 


Asn Ala Glu Val Leu Ala Leu Phe Asn Val Thr Glu Ala Asp Ala Gly 
                325                 330                 335     


Glu Tyr Ile Cys Lys Val Ser Asn Tyr Ile Gly Gln Ala Asn Gln Ser 
            340                 345                 350         


Ala Trp Leu Thr Val Leu Pro Lys Gln Gln Ala Pro Gly Arg Glu Lys 
        355                 360                 365             


Glu Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile 
    370                 375                 380                 


Gly Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg 
385                 390                 395                 400 


Met Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val 
                405                 410                 415     


His Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser 
            420                 425                 430         


Ala Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile 
        435                 440                 445             


Thr Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val 
    450                 455                 460                 


Ser Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp 
465                 470                 475                 480 


Lys Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val 
                485                 490                 495     


Val Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala 
            500                 505                 510         


Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp 
        515                 520                 525             


Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys 
    530                 535                 540                 


His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro 
545                 550                 555                 560 


Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr 
                565                 570                 575     


Leu Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn 
            580                 585                 590         


Arg Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr 
        595                 600                 605             


Tyr Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile 
    610                 615                 620                 


His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val 
625                 630                 635                 640 


Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp 
                645                 650                 655     


Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala 
            660                 665                 670         


Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp 
        675                 680                 685             


Ser Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro 
    690                 695                 700                 


Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly 
705                 710                 715                 720 


His Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met 
                725                 730                 735     


Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys 
            740                 745                 750         


Gln Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu 
        755                 760                 765             


Glu Tyr Leu Asp Leu Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr 
    770                 775                 780                 


Pro Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser 
785                 790                 795                 800 


Pro Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile 
                805                 810                 815     


Asn Gly Ser Val Lys Thr 
            820         


<210>  4968
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  4968

Met Val Cys Ala Arg Ala Ala Leu Gly Pro Gly Ala Leu Trp Ala Ala 
1               5                   10                  15      


Ala Trp Gly Val Leu Leu Leu Thr Ala Pro Ala Gly Ala Gln Arg Gly 
            20                  25                  30          


Arg Lys Lys Val Val His Val Leu Glu Gly Glu Ser Gly Ser Val Val 
        35                  40                  45              


Val Gln Thr Ala Pro Gly Gln Val Val Ser His Arg Gly Gly Thr Ile 
    50                  55                  60                  


Val Leu Pro Cys Arg Tyr His Tyr Glu Ala Ala Ala His Gly His Asp 
65                  70                  75                  80  


Gly Val Arg Leu Lys Trp Thr Lys Val Val Asp Pro Leu Ala Phe Thr 
                85                  90                  95      


Asp Val Phe Val Ala Leu Gly Pro Gln His Arg Ala Phe Gly Ser Tyr 
            100                 105                 110         


Arg Gly Arg Ala Glu Leu Gln Gly Asp Gly Pro Gly Asp Ala Ser Leu 
        115                 120                 125             


Val Leu Arg Asn Val Thr Leu Gln Asp Tyr Gly Arg Tyr Glu Cys Glu 
    130                 135                 140                 


Val Thr Asn Glu Leu Glu Asp Asp Ala Gly Met Val Lys Leu Asp Leu 
145                 150                 155                 160 


Glu Gly Val Val Phe Pro Tyr His Pro Arg Gly Gly Arg Tyr Lys Leu 
                165                 170                 175     


Thr Phe Ala Glu Ala Gln Arg Ala Cys Ala Glu Gln Asp Gly Ile Leu 
            180                 185                 190         


Ala Ser Ala Glu Gln Leu His Ala Ala Trp Arg Asp Gly Leu Asp Trp 
        195                 200                 205             


Cys Asn Ala Gly Trp Leu Arg Asp Gly Ser Val Gln Tyr Pro Val Asn 
    210                 215                 220                 


Arg Pro Arg Glu Pro Cys Gly Gly Leu Gly Gly Thr Gly Ser Ala Gly 
225                 230                 235                 240 


Gly Gly Gly Asp Ala Asn Gly Gly Leu Arg Asn Tyr Gly Tyr Arg His 
                245                 250                 255     


Asn Ala Glu Glu Arg Tyr Asp Ala Phe Cys Phe Thr Ser Asn Leu Pro 
            260                 265                 270         


Gly Arg Val Phe Phe Leu Lys Pro Leu Arg Pro Val Pro Phe Ser Gly 
        275                 280                 285             


Ala Ala Arg Ala Cys Ala Ala Arg Gly Ala Ala Val Ala Lys Val Gly 
    290                 295                 300                 


Gln Leu Phe Ala Ala Trp Lys Leu Gln Leu Leu Asp Arg Cys Thr Ala 
305                 310                 315                 320 


Gly Trp Leu Ala Asp Gly Ser Ala Arg Tyr Pro Ile Val Asn Pro Arg 
                325                 330                 335     


Ala Arg Cys Gly Gly Arg Arg Pro Gly Val Arg Ser Leu Gly Phe Pro 
            340                 345                 350         


Asp Ala Thr Arg Arg Leu Phe Gly Val Tyr Cys Tyr Arg Ala Pro Gly 
        355                 360                 365             


Ala Pro Asp Pro Ala Pro Gly Gly Trp Gly Trp Gly Trp Ala Gly Gly 
    370                 375                 380                 


Gly Gly Trp Ala Gly Gly Ala Arg Asp Pro Ala Ala Trp Thr Pro Leu 
385                 390                 395                 400 


His Val 
        


<210>  4969
<211>  918
<212>  PRT
<213>  Homo sapiens

<400>  4969

Met Pro Gly Gly Ala Gly Ala Ala Arg Leu Cys Leu Leu Ala Phe Ala 
1               5                   10                  15      


Leu Gln Pro Leu Arg Pro Arg Ala Ala Arg Glu Pro Gly Trp Thr Arg 
            20                  25                  30          


Gly Ser Glu Glu Gly Ser Pro Lys Leu Gln His Glu Leu Ile Ile Pro 
        35                  40                  45              


Gln Trp Lys Thr Ser Glu Ser Pro Val Arg Glu Lys His Pro Leu Lys 
    50                  55                  60                  


Ala Glu Leu Arg Val Met Ala Glu Gly Arg Glu Leu Ile Leu Asp Leu 
65                  70                  75                  80  


Glu Lys Asn Glu Gln Leu Phe Ala Pro Ser Tyr Thr Glu Thr His Tyr 
                85                  90                  95      


Thr Ser Ser Gly Asn Pro Gln Thr Thr Thr Arg Lys Leu Glu Asp His 
            100                 105                 110         


Cys Phe Tyr His Gly Thr Val Arg Glu Thr Glu Leu Ser Ser Val Thr 
        115                 120                 125             


Leu Ser Thr Cys Arg Gly Ile Arg Gly Leu Ile Thr Val Ser Ser Asn 
    130                 135                 140                 


Leu Ser Tyr Val Ile Glu Pro Leu Pro Asp Ser Lys Gly Gln His Leu 
145                 150                 155                 160 


Ile Tyr Arg Ser Glu His Leu Lys Pro Pro Pro Gly Asn Cys Gly Phe 
                165                 170                 175     


Glu His Ser Lys Pro Thr Thr Arg Asp Trp Ala Leu Gln Phe Thr Gln 
            180                 185                 190         


Gln Thr Lys Lys Arg Pro Arg Arg Met Lys Arg Glu Asp Leu Asn Ser 
        195                 200                 205             


Met Lys Tyr Val Glu Leu Tyr Leu Val Ala Asp Tyr Leu Glu Phe Gln 
    210                 215                 220                 


Lys Asn Arg Arg Asp Gln Asp Ala Thr Lys His Lys Leu Ile Glu Ile 
225                 230                 235                 240 


Ala Asn Tyr Val Asp Lys Phe Tyr Arg Ser Leu Asn Ile Arg Ile Ala 
                245                 250                 255     


Leu Val Gly Leu Glu Val Trp Thr His Gly Asn Met Cys Glu Val Ser 
            260                 265                 270         


Glu Asn Pro Tyr Ser Thr Leu Trp Ser Phe Leu Ser Trp Arg Arg Lys 
        275                 280                 285             


Leu Leu Ala Gln Lys Tyr His Asp Asn Ala Gln Leu Ile Thr Gly Met 
    290                 295                 300                 


Ser Phe His Gly Thr Thr Ile Gly Leu Ala Pro Leu Met Ala Met Cys 
305                 310                 315                 320 


Ser Val Tyr Gln Ser Gly Gly Val Asn Met Asp His Ser Glu Asn Ala 
                325                 330                 335     


Ile Gly Val Ala Ala Thr Met Ala His Glu Met Gly His Asn Phe Gly 
            340                 345                 350         


Met Thr His Asp Ser Ala Asp Cys Cys Ser Ala Ser Ala Ala Asp Gly 
        355                 360                 365             


Gly Cys Ile Met Ala Ala Ala Thr Gly His Pro Phe Pro Lys Val Phe 
    370                 375                 380                 


Asn Gly Cys Asn Arg Arg Glu Leu Asp Arg Tyr Leu Gln Ser Gly Gly 
385                 390                 395                 400 


Gly Met Cys Leu Ser Asn Met Pro Asp Thr Arg Met Leu Tyr Gly Gly 
                405                 410                 415     


Arg Arg Cys Gly Asn Gly Tyr Leu Glu Asp Gly Glu Glu Cys Asp Cys 
            420                 425                 430         


Gly Glu Glu Glu Glu Cys Asn Asn Pro Cys Cys Asn Ala Ser Asn Cys 
        435                 440                 445             


Thr Leu Arg Pro Gly Ala Glu Cys Ala His Gly Ser Cys Cys His Gln 
    450                 455                 460                 


Cys Lys Leu Leu Ala Pro Gly Thr Leu Cys Arg Glu Gln Ala Arg Gln 
465                 470                 475                 480 


Cys Asp Leu Pro Glu Phe Cys Thr Gly Lys Ser Pro His Cys Pro Thr 
                485                 490                 495     


Asn Phe Tyr Gln Met Asp Gly Thr Pro Cys Glu Gly Gly Gln Ala Tyr 
            500                 505                 510         


Cys Tyr Asn Gly Met Cys Leu Thr Tyr Gln Glu Gln Cys Gln Gln Leu 
        515                 520                 525             


Trp Gly Pro Gly Ala Arg Pro Ala Pro Asp Leu Cys Phe Glu Lys Val 
    530                 535                 540                 


Asn Val Ala Gly Asp Thr Phe Gly Asn Cys Gly Lys Asp Met Asn Gly 
545                 550                 555                 560 


Glu His Arg Lys Cys Asn Met Arg Asp Ala Lys Cys Gly Lys Ile Gln 
                565                 570                 575     


Cys Gln Ser Ser Glu Ala Arg Pro Leu Glu Ser Asn Ala Val Pro Ile 
            580                 585                 590         


Asp Thr Thr Ile Ile Met Asn Gly Arg Gln Ile Gln Cys Arg Gly Thr 
        595                 600                 605             


His Val Tyr Arg Gly Pro Glu Glu Glu Gly Asp Met Leu Asp Pro Gly 
    610                 615                 620                 


Leu Val Met Thr Gly Thr Lys Cys Gly Tyr Asn His Ile Cys Phe Glu 
625                 630                 635                 640 


Gly Gln Cys Arg Asn Thr Ser Phe Phe Glu Thr Glu Gly Cys Gly Lys 
                645                 650                 655     


Lys Cys Asn Gly His Gly Val Cys Asn Asn Asn Gln Asn Cys His Cys 
            660                 665                 670         


Leu Pro Gly Trp Ala Pro Pro Phe Cys Asn Thr Pro Gly His Gly Gly 
        675                 680                 685             


Ser Ile Asp Ser Gly Pro Met Pro Pro Glu Ser Val Gly Pro Val Val 
    690                 695                 700                 


Ala Gly Val Leu Val Ala Ile Leu Val Leu Ala Val Leu Met Leu Met 
705                 710                 715                 720 


Tyr Tyr Cys Cys Arg Gln Asn Asn Lys Leu Gly Gln Leu Lys Pro Ser 
                725                 730                 735     


Ala Leu Pro Ser Lys Leu Arg Gln Gln Phe Ser Cys Pro Phe Arg Val 
            740                 745                 750         


Ser Gln Asn Ser Gly Thr Gly His Ala Asn Pro Thr Phe Lys Leu Gln 
        755                 760                 765             


Thr Pro Gln Gly Lys Arg Lys Val Ile Asn Thr Pro Glu Ile Leu Arg 
    770                 775                 780                 


Lys Pro Ser Gln Pro Pro Pro Arg Pro Pro Pro Asp Tyr Leu Arg Gly 
785                 790                 795                 800 


Gly Ser Pro Pro Ala Pro Leu Pro Ala His Leu Ser Arg Ala Ala Arg 
                805                 810                 815     


Asn Ser Pro Gly Pro Gly Ser Gln Ile Glu Arg Thr Glu Ser Ser Arg 
            820                 825                 830         


Arg Pro Pro Pro Ser Arg Pro Ile Pro Pro Ala Pro Asn Cys Ile Val 
        835                 840                 845             


Ser Gln Asp Phe Ser Arg Pro Arg Pro Pro Gln Lys Ala Leu Pro Ala 
    850                 855                 860                 


Asn Pro Val Pro Gly Arg Arg Ser Leu Pro Arg Pro Gly Gly Ala Ser 
865                 870                 875                 880 


Pro Leu Arg Pro Pro Gly Ala Gly Pro Gln Gln Ser Arg Pro Leu Ala 
                885                 890                 895     


Ala Leu Ala Pro Lys Phe Pro Glu Tyr Arg Ser Gln Arg Ala Gly Gly 
            900                 905                 910         


Met Ile Ser Ser Lys Ile 
        915             


<210>  4970
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  4970

Met Ser Ala Ser Ala Ala Thr Gly Val Phe Val Leu Ser Leu Ser Ala 
1               5                   10                  15      


Ile Pro Val Thr Tyr Val Phe Asn His Leu Ala Ala Gln His Asp Ser 
            20                  25                  30          


Trp Thr Ile Val Gly Val Ala Ala Leu Ile Leu Phe Leu Val Ala Leu 
        35                  40                  45              


Leu Ala Arg Val Leu Val Lys Arg Lys Pro Pro Arg Asp Pro Leu Phe 
    50                  55                  60                  


Tyr Val Tyr Ala Val Phe Gly Phe Thr Ser Val Val Asn Leu Ile Ile 
65                  70                  75                  80  


Gly Leu Glu Gln Asp Gly Ile Ile Asp Gly Phe Met Thr His Tyr Leu 
                85                  90                  95      


Arg Glu Gly Glu Pro Tyr Leu Asn Thr Ala Tyr Gly His Met Ile Cys 
            100                 105                 110         


Tyr Trp Asp Gly Ser Ala His Tyr Leu Met Tyr Leu Val Met Val Ala 
        115                 120                 125             


Ala Ile Ala Trp Glu Glu Thr Tyr Arg Thr Ile Gly Leu Tyr Trp Val 
    130                 135                 140                 


Gly Ser Ile Ile Met Ser Val Val Val Phe Val Pro Gly Asn Ile Val 
145                 150                 155                 160 


Gly Lys Tyr Gly Thr Arg Ile Cys Pro Ala Phe Phe Leu Ser Ile Pro 
                165                 170                 175     


Tyr Thr Cys Leu Pro Val Trp Ala Gly Phe Arg Ile Tyr Asn Gln Pro 
            180                 185                 190         


Ser Glu Asn Tyr Asn Tyr Pro Ser Lys Val Ile Gln Glu Ala Gln Ala 
        195                 200                 205             


Lys Asp Leu Leu Arg Arg Pro Phe Asp Leu Met Leu Val Val Cys Leu 
    210                 215                 220                 


Leu Leu Ala Thr Gly Phe Cys Leu Phe Arg Gly Leu Ile Ala Leu Asp 
225                 230                 235                 240 


Cys Pro Ser Glu Leu Cys Arg Leu Tyr Thr Gln Phe Gln Glu Pro Tyr 
                245                 250                 255     


Leu Lys Asp Pro Ala Ala Tyr Pro Lys Ile Gln Met Leu Ala Tyr Met 
            260                 265                 270         


Phe Tyr Ser Val Pro Tyr Phe Val Thr Ala Leu Tyr Gly Leu Val Val 
        275                 280                 285             


Pro Gly Cys Ser Trp Met Pro Asp Ile Thr Leu Ile His Ala Gly Gly 
    290                 295                 300                 


Leu Ala Gln Ala Gln Phe Ser His Ile Gly Ala Ser Leu His Ala Arg 
305                 310                 315                 320 


Thr Ala Tyr Val Tyr Arg Val Pro Glu Glu Ala Lys Ile Leu Phe Leu 
                325                 330                 335     


Ala Leu Asn Ile Ala Tyr Gly Val Leu Pro Gln Leu Leu Ala Tyr Arg 
            340                 345                 350         


Cys Ile Tyr Lys Pro Glu Phe Phe Ile Lys Thr Lys Ala Glu Glu Lys 
        355                 360                 365             


Val Glu 
    370 


<210>  4971
<211>  1709
<212>  PRT
<213>  Homo sapiens

<400>  4971

Met Gly Phe Leu Pro Lys Leu Leu Leu Leu Ala Ser Phe Phe Pro Ala 
1               5                   10                  15      


Gly Gln Ala Ser Trp Gly Val Ser Ser Pro Gln Asp Val Gln Gly Val 
            20                  25                  30          


Lys Gly Ser Cys Leu Leu Ile Pro Cys Ile Phe Ser Phe Pro Ala Asp 
        35                  40                  45              


Val Glu Val Pro Asp Gly Ile Thr Ala Ile Trp Tyr Tyr Asp Tyr Ser 
    50                  55                  60                  


Gly Gln Arg Gln Val Val Ser His Ser Ala Asp Pro Lys Leu Val Glu 
65                  70                  75                  80  


Ala Arg Phe Arg Gly Arg Thr Glu Phe Met Gly Asn Pro Glu His Arg 
                85                  90                  95      


Val Cys Asn Leu Leu Leu Lys Asp Leu Gln Pro Glu Asp Ser Gly Ser 
            100                 105                 110         


Tyr Asn Phe Arg Phe Glu Ile Ser Glu Val Asn Arg Trp Ser Asp Val 
        115                 120                 125             


Lys Gly Thr Leu Val Thr Val Thr Glu Glu Pro Arg Val Pro Thr Ile 
    130                 135                 140                 


Ala Ser Pro Val Glu Leu Leu Glu Gly Thr Glu Val Asp Phe Asn Cys 
145                 150                 155                 160 


Ser Thr Pro Tyr Val Cys Leu Gln Glu Gln Val Arg Leu Gln Trp Gln 
                165                 170                 175     


Gly Gln Asp Pro Ala Arg Ser Val Thr Phe Asn Ser Gln Lys Phe Glu 
            180                 185                 190         


Pro Thr Gly Val Gly His Leu Glu Thr Leu His Met Ala Met Ser Trp 
        195                 200                 205             


Gln Asp His Gly Arg Ile Leu Arg Cys Gln Leu Ser Val Ala Asn His 
    210                 215                 220                 


Arg Ala Gln Ser Glu Ile His Leu Gln Val Lys Tyr Ala Pro Lys Gly 
225                 230                 235                 240 


Val Lys Ile Leu Leu Ser Pro Ser Gly Arg Asn Ile Leu Pro Gly Glu 
                245                 250                 255     


Leu Val Thr Leu Thr Cys Gln Val Asn Ser Ser Tyr Pro Ala Val Ser 
            260                 265                 270         


Ser Ile Lys Trp Leu Lys Asp Gly Val Arg Leu Gln Thr Lys Thr Gly 
        275                 280                 285             


Val Leu His Leu Pro Gln Ala Ala Trp Ser Asp Ala Gly Val Tyr Thr 
    290                 295                 300                 


Cys Gln Ala Glu Asn Gly Val Gly Ser Leu Val Ser Pro Pro Ile Ser 
305                 310                 315                 320 


Leu His Ile Phe Met Ala Glu Val Gln Val Ser Pro Ala Gly Pro Ile 
                325                 330                 335     


Leu Glu Asn Gln Thr Val Thr Leu Val Cys Asn Thr Pro Asn Glu Ala 
            340                 345                 350         


Pro Ser Asp Leu Arg Tyr Ser Trp Tyr Lys Asn His Val Leu Leu Glu 
        355                 360                 365             


Asp Ala His Ser His Thr Leu Arg Leu His Leu Ala Thr Arg Ala Asp 
    370                 375                 380                 


Thr Gly Phe Tyr Phe Cys Glu Val Gln Asn Val His Gly Ser Glu Arg 
385                 390                 395                 400 


Ser Gly Pro Val Ser Val Val Val Asn His Pro Pro Leu Thr Pro Val 
                405                 410                 415     


Leu Thr Ala Phe Leu Glu Thr Gln Ala Gly Leu Val Gly Ile Leu His 
            420                 425                 430         


Cys Ser Val Val Ser Glu Pro Leu Ala Thr Leu Val Leu Ser His Gly 
        435                 440                 445             


Gly His Ile Leu Ala Ser Thr Ser Gly Asp Ser Asp His Ser Pro Arg 
    450                 455                 460                 


Phe Ser Gly Thr Ser Gly Pro Asn Ser Leu Arg Leu Glu Ile Arg Asp 
465                 470                 475                 480 


Leu Glu Glu Thr Asp Ser Gly Glu Tyr Lys Cys Ser Ala Thr Asn Ser 
                485                 490                 495     


Leu Gly Asn Ala Thr Ser Thr Leu Asp Phe His Ala Asn Ala Ala Arg 
            500                 505                 510         


Leu Leu Ile Ser Pro Ala Ala Glu Val Val Glu Gly Gln Ala Val Thr 
        515                 520                 525             


Leu Ser Cys Arg Ser Gly Leu Ser Pro Thr Pro Asp Ala Arg Phe Ser 
    530                 535                 540                 


Trp Tyr Leu Asn Gly Ala Leu Leu His Glu Gly Pro Gly Ser Ser Leu 
545                 550                 555                 560 


Leu Leu Pro Ala Ala Ser Ser Thr Asp Ala Gly Ser Tyr His Cys Arg 
                565                 570                 575     


Ala Arg Asp Gly His Ser Ala Ser Gly Pro Ser Ser Pro Ala Val Leu 
            580                 585                 590         


Thr Val Leu Tyr Pro Pro Arg Gln Pro Thr Phe Thr Thr Arg Leu Asp 
        595                 600                 605             


Leu Asp Ala Ala Gly Ala Gly Ala Gly Arg Arg Gly Leu Leu Leu Cys 
    610                 615                 620                 


Arg Val Asp Ser Asp Pro Pro Ala Arg Leu Gln Leu Leu His Lys Asp 
625                 630                 635                 640 


Arg Val Val Ala Thr Ser Leu Pro Ser Gly Gly Gly Cys Ser Thr Cys 
                645                 650                 655     


Gly Gly Cys Ser Pro Arg Met Lys Val Thr Lys Ala Pro Asn Leu Leu 
            660                 665                 670         


Arg Val Glu Ile His Asn Pro Leu Leu Glu Glu Glu Gly Leu Tyr Leu 
        675                 680                 685             


Cys Glu Ala Ser Asn Ala Leu Gly Asn Ala Ser Thr Ser Ala Thr Phe 
    690                 695                 700                 


Asn Gly Gln Ala Thr Val Leu Ala Ile Ala Pro Ser His Thr Leu Gln 
705                 710                 715                 720 


Glu Gly Thr Glu Ala Asn Leu Thr Cys Asn Val Ser Arg Glu Ala Ala 
                725                 730                 735     


Gly Ser Pro Ala Asn Phe Ser Trp Phe Arg Asn Gly Val Leu Trp Ala 
            740                 745                 750         


Gln Gly Pro Leu Glu Thr Val Thr Leu Leu Pro Val Ala Arg Thr Asp 
        755                 760                 765             


Ala Ala Leu Tyr Ala Cys Arg Ile Leu Thr Glu Ala Gly Ala Gln Leu 
    770                 775                 780                 


Ser Thr Pro Val Leu Leu Ser Val Leu Tyr Pro Pro Asp Arg Pro Lys 
785                 790                 795                 800 


Leu Ser Ala Leu Leu Asp Met Gly Gln Gly His Met Ala Leu Phe Ile 
                805                 810                 815     


Cys Thr Val Asp Ser Arg Pro Leu Ala Leu Leu Ala Leu Phe His Gly 
            820                 825                 830         


Glu His Leu Leu Ala Thr Ser Leu Gly Pro Gln Val Pro Ser His Gly 
        835                 840                 845             


Arg Phe Gln Ala Lys Ala Glu Ala Asn Ser Leu Lys Leu Glu Val Arg 
    850                 855                 860                 


Glu Leu Gly Leu Gly Asp Ser Gly Ser Tyr Arg Cys Glu Ala Thr Asn 
865                 870                 875                 880 


Val Leu Gly Ser Ser Asn Thr Ser Leu Phe Phe Gln Val Arg Gly Ala 
                885                 890                 895     


Trp Val Gln Val Ser Pro Ser Pro Glu Leu Gln Glu Gly Gln Ala Val 
            900                 905                 910         


Val Leu Ser Cys Gln Val His Thr Gly Val Pro Glu Gly Thr Ser Tyr 
        915                 920                 925             


Arg Trp Tyr Arg Asp Gly Gln Pro Leu Gln Glu Ser Thr Ser Ala Thr 
    930                 935                 940                 


Leu Arg Phe Ala Ala Ile Thr Leu Thr Gln Ala Gly Ala Tyr His Cys 
945                 950                 955                 960 


Gln Ala Gln Ala Pro Gly Ser Ala Thr Thr Ser Leu Ala Ala Pro Ile 
                965                 970                 975     


Ser Leu His Val Ser Tyr Ala Pro Arg His Val Thr Leu Thr Thr Leu 
            980                 985                 990         


Met Asp Thr Gly Pro Gly Arg Leu  Gly Leu Leu Leu Cys  Arg Val Asp 
        995                 1000                 1005             


Ser Asp  Pro Pro Ala Gln Leu  Arg Leu Leu His Gly  Asp Arg Leu 
    1010                 1015                 1020             


Val Ala  Ser Thr Leu Gln Gly  Val Gly Gly Pro Glu  Gly Ser Ser 
    1025                 1030                 1035             


Pro Arg  Leu His Val Ala Val  Ala Pro Asn Thr Leu  Arg Leu Glu 
    1040                 1045                 1050             


Ile His  Gly Ala Met Leu Glu  Asp Glu Gly Val Tyr  Ile Cys Glu 
    1055                 1060                 1065             


Ala Ser  Asn Thr Leu Gly Gln  Ala Ser Ala Ser Ala  Asp Phe Asp 
    1070                 1075                 1080             


Ala Gln  Ala Val Asn Val Gln  Val Trp Pro Gly Ala  Thr Val Arg 
    1085                 1090                 1095             


Glu Gly  Gln Leu Val Asn Leu  Thr Cys Leu Val Trp  Thr Thr His 
    1100                 1105                 1110             


Pro Ala  Gln Leu Thr Tyr Thr  Trp Tyr Gln Asp Gly  Gln Gln Arg 
    1115                 1120                 1125             


Leu Asp  Ala His Ser Ile Pro  Leu Pro Asn Val Thr  Val Arg Asp 
    1130                 1135                 1140             


Ala Thr  Ser Tyr Arg Cys Gly  Val Gly Pro Pro Gly  Arg Ala Pro 
    1145                 1150                 1155             


Arg Leu  Ser Arg Pro Ile Thr  Leu Asp Val Leu Tyr  Ala Pro Arg 
    1160                 1165                 1170             


Asn Leu  Arg Leu Thr Tyr Leu  Leu Glu Ser His Gly  Gly Gln Leu 
    1175                 1180                 1185             


Ala Leu  Val Leu Cys Thr Val  Asp Ser Arg Pro Pro  Ala Gln Leu 
    1190                 1195                 1200             


Ala Leu  Ser His Ala Gly Arg  Leu Leu Ala Ser Ser  Thr Ala Ala 
    1205                 1210                 1215             


Ser Val  Pro Asn Thr Leu Arg  Leu Glu Leu Arg Gly  Pro Gln Pro 
    1220                 1225                 1230             


Arg Asp  Glu Gly Phe Tyr Ser  Cys Ser Ala Arg Ser  Pro Leu Gly 
    1235                 1240                 1245             


Gln Ala  Asn Thr Ser Leu Glu  Leu Arg Leu Glu Gly  Val Arg Val 
    1250                 1255                 1260             


Ile Leu  Ala Pro Glu Ala Ala  Val Pro Glu Gly Ala  Pro Ile Thr 
    1265                 1270                 1275             


Val Thr  Cys Ala Asp Pro Ala  Ala His Ala Pro Thr  Leu Tyr Thr 
    1280                 1285                 1290             


Trp Tyr  His Asn Gly Arg Trp  Leu Gln Glu Gly Pro  Ala Ala Ser 
    1295                 1300                 1305             


Leu Ser  Phe Leu Val Ala Thr  Arg Ala His Ala Gly  Ala Tyr Ser 
    1310                 1315                 1320             


Cys Gln  Ala Gln Asp Ala Gln  Gly Thr Arg Ser Ser  Arg Pro Ala 
    1325                 1330                 1335             


Ala Leu  Gln Val Leu Tyr Ala  Pro Gln Asp Ala Val  Leu Ser Ser 
    1340                 1345                 1350             


Phe Arg  Asp Ser Arg Ala Arg  Ser Met Ala Val Ile  Gln Cys Thr 
    1355                 1360                 1365             


Val Asp  Ser Glu Pro Pro Ala  Glu Leu Ala Leu Ser  His Asp Gly 
    1370                 1375                 1380             


Lys Val  Leu Ala Thr Ser Ser  Gly Val His Ser Leu  Ala Ser Gly 
    1385                 1390                 1395             


Thr Gly  His Val Gln Val Ala  Arg Asn Ala Leu Arg  Leu Gln Val 
    1400                 1405                 1410             


Gln Asp  Val Pro Ala Gly Asp  Asp Thr Tyr Val Cys  Thr Ala Gln 
    1415                 1420                 1425             


Asn Leu  Leu Gly Ser Ile Ser  Thr Ile Gly Arg Leu  Gln Val Glu 
    1430                 1435                 1440             


Gly Ala  Arg Val Val Ala Glu  Pro Gly Leu Asp Val  Pro Glu Gly 
    1445                 1450                 1455             


Ala Ala  Leu Asn Leu Ser Cys  Arg Leu Leu Gly Gly  Pro Gly Pro 
    1460                 1465                 1470             


Val Gly  Asn Ser Thr Phe Ala  Trp Phe Trp Asn Asp  Arg Arg Leu 
    1475                 1480                 1485             


His Ala  Glu Pro Val Pro Thr  Leu Ala Phe Thr His  Val Ala Arg 
    1490                 1495                 1500             


Ala Gln  Ala Gly Met Tyr His  Cys Leu Ala Glu Leu  Pro Thr Gly 
    1505                 1510                 1515             


Ala Ala  Ala Ser Ala Pro Val  Met Leu Arg Val Leu  Tyr Pro Pro 
    1520                 1525                 1530             


Lys Thr  Pro Thr Met Met Val  Phe Val Glu Pro Glu  Gly Gly Leu 
    1535                 1540                 1545             


Arg Gly  Ile Leu Asp Cys Arg  Val Asp Ser Glu Pro  Leu Ala Ser 
    1550                 1555                 1560             


Leu Thr  Leu His Leu Gly Ser  Arg Leu Val Ala Ser  Ser Gln Pro 
    1565                 1570                 1575             


Gln Gly  Ala Pro Ala Glu Pro  His Ile His Val Leu  Ala Ser Pro 
    1580                 1585                 1590             


Asn Ala  Leu Arg Val Asp Ile  Glu Ala Leu Arg Pro  Ser Asp Gln 
    1595                 1600                 1605             


Gly Glu  Tyr Ile Cys Ser Ala  Ser Asn Val Leu Gly  Ser Ala Ser 
    1610                 1615                 1620             


Thr Ser  Thr Tyr Phe Gly Val  Arg Ala Leu His Arg  Leu His Gln 
    1625                 1630                 1635             


Phe Gln  Gln Leu Leu Trp Val  Leu Gly Leu Leu Val  Gly Leu Leu 
    1640                 1645                 1650             


Leu Leu  Leu Leu Gly Leu Gly  Ala Cys Tyr Thr Trp  Arg Arg Arg 
    1655                 1660                 1665             


Arg Val  Cys Lys Gln Ser Met  Gly Glu Asn Ser Val  Glu Met Ala 
    1670                 1675                 1680             


Phe Gln  Lys Glu Thr Thr Gln  Leu Ile Asp Pro Asp  Ala Ala Thr 
    1685                 1690                 1695             


Cys Glu  Thr Ser Thr Cys Ala  Pro Pro Leu Gly 
    1700                 1705                 


<210>  4972
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  4972

Met Ala Met Ile Glu Leu Gly Phe Gly Arg Gln Asn Phe His Pro Leu 
1               5                   10                  15      


Lys Arg Lys Ser Ser Leu Leu Leu Lys Leu Ile Ala Val Val Phe Ala 
            20                  25                  30          


Val Leu Leu Phe Cys Glu Phe Leu Ile Tyr Tyr Leu Ala Ile Phe Gln 
        35                  40                  45              


Cys Asn Trp Pro Glu Val Lys Thr Thr Ala Ser Asp Gly Glu Gln Thr 
    50                  55                  60                  


Thr Arg Glu Pro Val Leu Lys Ala Met Phe Leu Ala Asp Thr His Leu 
65                  70                  75                  80  


Leu Gly Glu Phe Leu Gly His Trp Leu Asp Lys Leu Arg Arg Glu Trp 
                85                  90                  95      


Gln Met Glu Arg Ala Phe Gln Thr Ala Leu Trp Leu Leu Gln Pro Glu 
            100                 105                 110         


Val Val Phe Ile Leu Gly Asp Ile Phe Asp Glu Gly Lys Trp Ser Thr 
        115                 120                 125             


Pro Glu Ala Trp Ala Asp Asp Val Glu Arg Phe Gln Lys Met Phe Arg 
    130                 135                 140                 


His Pro Ser His Val Gln Leu Lys Val Val Ala Gly Asn His Asp Ile 
145                 150                 155                 160 


Gly Phe His Tyr Glu Met Asn Thr Tyr Lys Val Glu Arg Phe Glu Lys 
                165                 170                 175     


Val Phe Ser Ser Glu Arg Leu Phe Ser Trp Lys Gly Ile Asn Phe Val 
            180                 185                 190         


Met Val Asn Ser Val Ala Leu Asn Gly Asp Gly Cys Gly Ile Cys Ser 
        195                 200                 205             


Glu Thr Glu Ala Glu Leu Ile Glu Val Ser His Arg Leu Asn Cys Ser 
    210                 215                 220                 


Arg Glu Ala Arg Gly Ser Ser Arg Cys Gly Pro Gly Pro Leu Leu Pro 
225                 230                 235                 240 


Thr Ser Ala Pro Val Leu Leu Gln His Tyr Pro Leu Tyr Arg Arg Ser 
                245                 250                 255     


Asp Ala Asn Cys Ser Gly Glu Asp Ala Ala Pro Ala Glu Glu Arg Asp 
            260                 265                 270         


Ile Pro Phe Lys Glu Asn Tyr Asp Val Leu Ser Arg Glu Ala Ser Gln 
        275                 280                 285             


Lys Leu Leu Trp Trp Leu Gln Pro Arg Leu Val Leu Ser Gly His Thr 
    290                 295                 300                 


His Ser Ala Cys Glu Val His His Gly Gly Arg Val Pro Glu Leu Ser 
305                 310                 315                 320 


Val Pro Ser Phe Ser Trp Arg Asn Arg Asn Asn Pro Ser Phe Ile Met 
                325                 330                 335     


Gly Ser Ile Thr Pro Thr Asp Tyr Thr Leu Ser Lys Cys Tyr Leu Pro 
            340                 345                 350         


Arg Glu Asp Val Val Leu Ile Ile Tyr Cys Gly Val Val Gly Phe Leu 
        355                 360                 365             


Val Val Leu Thr Leu Thr His Phe Gly Leu Leu Ala Ser Pro Phe Leu 
    370                 375                 380                 


Ser Gly Leu Asn Leu Leu Gly Lys Arg Lys Thr Arg 
385                 390                 395     


<210>  4973
<211>  733
<212>  PRT
<213>  Homo sapiens

<400>  4973

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Asp Ala 
            20                  25                  30          


Leu Pro Ser Ser Glu Asp Asp Asp Asp Asp Asp Asp Ser Ser Ser Glu 
        35                  40                  45              


Glu Lys Glu Thr Asp Asn Thr Lys Pro Asn Arg Met Pro Val Ala Pro 
    50                  55                  60                  


Tyr Trp Thr Ser Pro Glu Lys Met Glu Lys Lys Leu His Ala Val Pro 
65                  70                  75                  80  


Ala Ala Lys Thr Val Lys Phe Lys Cys Pro Ser Ser Gly Thr Pro Asn 
                85                  90                  95      


Pro Thr Leu Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Pro Asp His 
            100                 105                 110         


Arg Ile Gly Gly Tyr Lys Val Arg Tyr Ala Thr Trp Ser Ile Ile Met 
        115                 120                 125             


Asp Ser Val Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Ile Val Glu 
    130                 135                 140                 


Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr Gln Leu Asp Val Val Glu 
145                 150                 155                 160 


Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Lys 
                165                 170                 175     


Thr Val Ala Leu Gly Ser Asn Val Glu Phe Met Cys Lys Val Tyr Ser 
            180                 185                 190         


Asp Pro Gln Pro His Ile Gln Trp Leu Lys His Ile Glu Val Asn Gly 
        195                 200                 205             


Ser Lys Ile Gly Pro Asp Asn Leu Pro Tyr Val Gln Ile Leu Lys Thr 
    210                 215                 220                 


Ala Gly Val Asn Thr Thr Asp Lys Glu Met Glu Val Leu His Leu Arg 
225                 230                 235                 240 


Asn Val Ser Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn 
                245                 250                 255     


Ser Ile Gly Leu Ser His His Ser Ala Trp Leu Thr Val Leu Glu Ala 
            260                 265                 270         


Leu Glu Glu Arg Pro Ala Val Met Thr Ser Pro Leu Tyr Leu Glu Ile 
        275                 280                 285             


Ile Ile Tyr Cys Thr Gly Ala Phe Leu Ile Ser Cys Met Val Gly Ser 
    290                 295                 300                 


Val Ile Val Tyr Lys Met Lys Ser Gly Thr Lys Lys Ser Asp Phe His 
305                 310                 315                 320 


Ser Gln Met Ala Val His Lys Leu Ala Lys Ser Ile Pro Leu Arg Arg 
                325                 330                 335     


Gln Val Thr Val Ser Ala Asp Ser Ser Ala Ser Met Asn Ser Gly Val 
            340                 345                 350         


Leu Leu Val Arg Pro Ser Arg Leu Ser Ser Ser Gly Thr Pro Met Leu 
        355                 360                 365             


Ala Gly Val Ser Glu Tyr Glu Leu Pro Glu Asp Pro Arg Trp Glu Leu 
    370                 375                 380                 


Pro Arg Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe 
385                 390                 395                 400 


Gly Gln Val Val Leu Ala Glu Ala Ile Gly Leu Asp Lys Asp Lys Pro 
                405                 410                 415     


Asn Arg Val Thr Lys Val Ala Val Lys Met Leu Lys Ser Asp Ala Thr 
            420                 425                 430         


Glu Lys Asp Leu Ser Asp Leu Ile Ser Glu Met Glu Met Met Lys Met 
        435                 440                 445             


Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln 
    450                 455                 460                 


Asp Gly Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu 
465                 470                 475                 480 


Arg Glu Tyr Leu Gln Ala Arg Arg Pro Pro Gly Leu Glu Tyr Cys Tyr 
                485                 490                 495     


Asn Pro Ser His Asn Pro Glu Glu Gln Leu Ser Ser Lys Asp Leu Val 
            500                 505                 510         


Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Lys 
        515                 520                 525             


Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu 
    530                 535                 540                 


Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile His 
545                 550                 555                 560 


His Ile Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys 
                565                 570                 575     


Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Ile Tyr Thr His Gln Ser 
            580                 585                 590         


Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly 
        595                 600                 605             


Gly Ser Pro Tyr Pro Gly Val Pro Val Glu Glu Leu Phe Lys Leu Leu 
    610                 615                 620                 


Lys Glu Gly His Arg Met Asp Lys Pro Ser Asn Cys Thr Asn Glu Leu 
625                 630                 635                 640 


Tyr Met Met Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro 
                645                 650                 655     


Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Ile Val Ala Leu Thr 
            660                 665                 670         


Ser Asn Gln Glu Tyr Leu Asp Leu Ser Met Pro Leu Asp Gln Tyr Ser 
        675                 680                 685             


Pro Ser Phe Pro Asp Thr Arg Ser Ser Thr Cys Ser Ser Gly Glu Asp 
    690                 695                 700                 


Ser Val Phe Ser His Glu Pro Leu Pro Glu Glu Pro Cys Leu Pro Arg 
705                 710                 715                 720 


His Pro Ala Gln Leu Ala Asn Gly Gly Leu Lys Arg Arg 
                725                 730             


<210>  4974
<211>  820
<212>  PRT
<213>  Homo sapiens

<400>  4974

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          


Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly 
        35                  40                  45              


Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  


Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg 
65                  70                  75                  80  


Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser 
                85                  90                  95      


Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr 
            100                 105                 110         


Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
        115                 120                 125             


Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
    130                 135                 140                 


Lys Pro Asn Arg Met Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
145                 150                 155                 160 


Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
                165                 170                 175     


Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
            180                 185                 190         


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
        195                 200                 205             


Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
    210                 215                 220                 


Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
225                 230                 235                 240 


His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
                245                 250                 255     


Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
            260                 265                 270         


Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
        275                 280                 285             


Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
    290                 295                 300                 


Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp 
305                 310                 315                 320 


Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala 
                325                 330                 335     


Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His 
            340                 345                 350         


Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val 
        355                 360                 365             


Met Thr Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala 
    370                 375                 380                 


Phe Leu Ile Ser Cys Met Val Gly Ser Val Ile Val Tyr Lys Met Lys 
385                 390                 395                 400 


Ser Gly Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys 
                405                 410                 415     


Leu Ala Lys Ser Ile Pro Leu Arg Arg Gln Val Ser Ala Asp Ser Ser 
            420                 425                 430         


Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg Leu Ser 
        435                 440                 445             


Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro 
    450                 455                 460                 


Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu Gly Lys 
465                 470                 475                 480 


Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu Ala Ile 
                485                 490                 495     


Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala Val Lys 
            500                 505                 510         


Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Ile Ser 
        515                 520                 525             


Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn 
    530                 535                 540                 


Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu 
545                 550                 555                 560 


Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg Arg Pro 
                565                 570                 575     


Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu Glu Gln 
            580                 585                 590         


Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly 
        595                 600                 605             


Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu Ala Ala 
    610                 615                 620                 


Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe 
625                 630                 635                 640 


Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys Thr Thr 
                645                 650                 655     


Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp 
            660                 665                 670         


Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu 
        675                 680                 685             


Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val Pro Val 
    690                 695                 700                 


Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro 
705                 710                 715                 720 


Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp His 
                725                 730                 735     


Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu 
            740                 745                 750         


Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp Leu Ser 
        755                 760                 765             


Met Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg Ser Ser 
    770                 775                 780                 


Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro Leu Pro 
785                 790                 795                 800 


Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln Leu Ala Asn Gly Gly 
                805                 810                 815     


Leu Lys Arg Arg 
            820 


<210>  4975
<211>  820
<212>  PRT
<213>  Homo sapiens

<400>  4975

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          


Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly 
        35                  40                  45              


Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  


Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg 
65                  70                  75                  80  


Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser 
                85                  90                  95      


Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr 
            100                 105                 110         


Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
        115                 120                 125             


Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
    130                 135                 140                 


Lys Pro Asn Arg Met Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
145                 150                 155                 160 


Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
                165                 170                 175     


Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
            180                 185                 190         


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
        195                 200                 205             


Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
    210                 215                 220                 


Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
225                 230                 235                 240 


His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
                245                 250                 255     


Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
            260                 265                 270         


Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
        275                 280                 285             


Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
    290                 295                 300                 


Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp 
305                 310                 315                 320 


Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala 
                325                 330                 335     


Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His 
            340                 345                 350         


Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val 
        355                 360                 365             


Met Thr Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala 
    370                 375                 380                 


Phe Leu Ile Ser Cys Met Val Gly Ser Val Ile Val Tyr Lys Met Lys 
385                 390                 395                 400 


Ser Gly Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys 
                405                 410                 415     


Leu Ala Lys Ser Ile Pro Leu Arg Arg Gln Val Ser Ala Asp Ser Ser 
            420                 425                 430         


Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg Leu Ser 
        435                 440                 445             


Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro 
    450                 455                 460                 


Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu Gly Lys 
465                 470                 475                 480 


Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu Ala Ile 
                485                 490                 495     


Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala Val Lys 
            500                 505                 510         


Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Ile Ser 
        515                 520                 525             


Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn 
    530                 535                 540                 


Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu 
545                 550                 555                 560 


Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg Arg Pro 
                565                 570                 575     


Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu Glu Gln 
            580                 585                 590         


Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly 
        595                 600                 605             


Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu Ala Ala 
    610                 615                 620                 


Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe 
625                 630                 635                 640 


Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys Thr Thr 
                645                 650                 655     


Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp 
            660                 665                 670         


Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu 
        675                 680                 685             


Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val Pro Val 
    690                 695                 700                 


Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro 
705                 710                 715                 720 


Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp His 
                725                 730                 735     


Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu 
            740                 745                 750         


Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp Leu Ser 
        755                 760                 765             


Met Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg Ser Ser 
    770                 775                 780                 


Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro Leu Pro 
785                 790                 795                 800 


Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln Leu Ala Asn Gly Gly 
                805                 810                 815     


Leu Lys Arg Arg 
            820 


<210>  4976
<211>  731
<212>  PRT
<213>  Homo sapiens

<400>  4976

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Asp Ala 
            20                  25                  30          


Leu Pro Ser Ser Glu Asp Asp Asp Asp Asp Asp Asp Ser Ser Ser Glu 
        35                  40                  45              


Glu Lys Glu Thr Asp Asn Thr Lys Pro Asn Pro Val Ala Pro Tyr Trp 
    50                  55                  60                  


Thr Ser Pro Glu Lys Met Glu Lys Lys Leu His Ala Val Pro Ala Ala 
65                  70                  75                  80  


Lys Thr Val Lys Phe Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr 
                85                  90                  95      


Leu Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile 
            100                 105                 110         


Gly Gly Tyr Lys Val Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser 
        115                 120                 125             


Val Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu 
    130                 135                 140                 


Tyr Gly Ser Ile Asn His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser 
145                 150                 155                 160 


Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val 
                165                 170                 175     


Ala Leu Gly Ser Asn Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro 
            180                 185                 190         


Gln Pro His Ile Gln Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys 
        195                 200                 205             


Ile Gly Pro Asp Asn Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly 
    210                 215                 220                 


Val Asn Thr Thr Asp Lys Glu Met Glu Val Leu His Leu Arg Asn Val 
225                 230                 235                 240 


Ser Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile 
                245                 250                 255     


Gly Leu Ser His His Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu 
            260                 265                 270         


Glu Arg Pro Ala Val Met Thr Ser Pro Leu Tyr Leu Glu Ile Ile Ile 
        275                 280                 285             


Tyr Cys Thr Gly Ala Phe Leu Ile Ser Cys Met Val Gly Ser Val Ile 
    290                 295                 300                 


Val Tyr Lys Met Lys Ser Gly Thr Lys Lys Ser Asp Phe His Ser Gln 
305                 310                 315                 320 


Met Ala Val His Lys Leu Ala Lys Ser Ile Pro Leu Arg Arg Gln Val 
                325                 330                 335     


Thr Val Ser Ala Asp Ser Ser Ala Ser Met Asn Ser Gly Val Leu Leu 
            340                 345                 350         


Val Arg Pro Ser Arg Leu Ser Ser Ser Gly Thr Pro Met Leu Ala Gly 
        355                 360                 365             


Val Ser Glu Tyr Glu Leu Pro Glu Asp Pro Arg Trp Glu Leu Pro Arg 
    370                 375                 380                 


Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln 
385                 390                 395                 400 


Val Val Leu Ala Glu Ala Ile Gly Leu Asp Lys Asp Lys Pro Asn Arg 
                405                 410                 415     


Val Thr Lys Val Ala Val Lys Met Leu Lys Ser Asp Ala Thr Glu Lys 
            420                 425                 430         


Asp Leu Ser Asp Leu Ile Ser Glu Met Glu Met Met Lys Met Ile Gly 
        435                 440                 445             


Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly 
    450                 455                 460                 


Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu 
465                 470                 475                 480 


Tyr Leu Gln Ala Arg Arg Pro Pro Gly Leu Glu Tyr Cys Tyr Asn Pro 
                485                 490                 495     


Ser His Asn Pro Glu Glu Gln Leu Ser Ser Lys Asp Leu Val Ser Cys 
            500                 505                 510         


Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Lys Lys Cys 
        515                 520                 525             


Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn 
    530                 535                 540                 


Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile His His Ile 
545                 550                 555                 560 


Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met 
                565                 570                 575     


Ala Pro Glu Ala Leu Phe Asp Arg Ile Tyr Thr His Gln Ser Asp Val 
            580                 585                 590         


Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser 
        595                 600                 605             


Pro Tyr Pro Gly Val Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu 
    610                 615                 620                 


Gly His Arg Met Asp Lys Pro Ser Asn Cys Thr Asn Glu Leu Tyr Met 
625                 630                 635                 640 


Met Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe 
                645                 650                 655     


Lys Gln Leu Val Glu Asp Leu Asp Arg Ile Val Ala Leu Thr Ser Asn 
            660                 665                 670         


Gln Glu Tyr Leu Asp Leu Ser Met Pro Leu Asp Gln Tyr Ser Pro Ser 
        675                 680                 685             


Phe Pro Asp Thr Arg Ser Ser Thr Cys Ser Ser Gly Glu Asp Ser Val 
    690                 695                 700                 


Phe Ser His Glu Pro Leu Pro Glu Glu Pro Cys Leu Pro Arg His Pro 
705                 710                 715                 720 


Ala Gln Leu Ala Asn Gly Gly Leu Lys Arg Arg 
                725                 730     


<210>  4977
<211>  731
<212>  PRT
<213>  Homo sapiens

<400>  4977

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Asp Ala 
            20                  25                  30          


Leu Pro Ser Ser Glu Asp Asp Asp Asp Asp Asp Asp Ser Ser Ser Glu 
        35                  40                  45              


Glu Lys Glu Thr Asp Asn Thr Lys Pro Asn Pro Val Ala Pro Tyr Trp 
    50                  55                  60                  


Thr Ser Pro Glu Lys Met Glu Lys Lys Leu His Ala Val Pro Ala Ala 
65                  70                  75                  80  


Lys Thr Val Lys Phe Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr 
                85                  90                  95      


Leu Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile 
            100                 105                 110         


Gly Gly Tyr Lys Val Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser 
        115                 120                 125             


Val Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu 
    130                 135                 140                 


Tyr Gly Ser Ile Asn His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser 
145                 150                 155                 160 


Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val 
                165                 170                 175     


Ala Leu Gly Ser Asn Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro 
            180                 185                 190         


Gln Pro His Ile Gln Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys 
        195                 200                 205             


Ile Gly Pro Asp Asn Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly 
    210                 215                 220                 


Val Asn Thr Thr Asp Lys Glu Met Glu Val Leu His Leu Arg Asn Val 
225                 230                 235                 240 


Ser Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile 
                245                 250                 255     


Gly Leu Ser His His Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu 
            260                 265                 270         


Glu Arg Pro Ala Val Met Thr Ser Pro Leu Tyr Leu Glu Ile Ile Ile 
        275                 280                 285             


Tyr Cys Thr Gly Ala Phe Leu Ile Ser Cys Met Val Gly Ser Val Ile 
    290                 295                 300                 


Val Tyr Lys Met Lys Ser Gly Thr Lys Lys Ser Asp Phe His Ser Gln 
305                 310                 315                 320 


Met Ala Val His Lys Leu Ala Lys Ser Ile Pro Leu Arg Arg Gln Val 
                325                 330                 335     


Thr Val Ser Ala Asp Ser Ser Ala Ser Met Asn Ser Gly Val Leu Leu 
            340                 345                 350         


Val Arg Pro Ser Arg Leu Ser Ser Ser Gly Thr Pro Met Leu Ala Gly 
        355                 360                 365             


Val Ser Glu Tyr Glu Leu Pro Glu Asp Pro Arg Trp Glu Leu Pro Arg 
    370                 375                 380                 


Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln 
385                 390                 395                 400 


Val Val Leu Ala Glu Ala Ile Gly Leu Asp Lys Asp Lys Pro Asn Arg 
                405                 410                 415     


Val Thr Lys Val Ala Val Lys Met Leu Lys Ser Asp Ala Thr Glu Lys 
            420                 425                 430         


Asp Leu Ser Asp Leu Ile Ser Glu Met Glu Met Met Lys Met Ile Gly 
        435                 440                 445             


Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly 
    450                 455                 460                 


Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu 
465                 470                 475                 480 


Tyr Leu Gln Ala Arg Arg Pro Pro Gly Leu Glu Tyr Cys Tyr Asn Pro 
                485                 490                 495     


Ser His Asn Pro Glu Glu Gln Leu Ser Ser Lys Asp Leu Val Ser Cys 
            500                 505                 510         


Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Lys Lys Cys 
        515                 520                 525             


Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn 
    530                 535                 540                 


Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile His His Ile 
545                 550                 555                 560 


Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met 
                565                 570                 575     


Ala Pro Glu Ala Leu Phe Asp Arg Ile Tyr Thr His Gln Ser Asp Val 
            580                 585                 590         


Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser 
        595                 600                 605             


Pro Tyr Pro Gly Val Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu 
    610                 615                 620                 


Gly His Arg Met Asp Lys Pro Ser Asn Cys Thr Asn Glu Leu Tyr Met 
625                 630                 635                 640 


Met Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe 
                645                 650                 655     


Lys Gln Leu Val Glu Asp Leu Asp Arg Ile Val Ala Leu Thr Ser Asn 
            660                 665                 670         


Gln Glu Tyr Leu Asp Leu Ser Met Pro Leu Asp Gln Tyr Ser Pro Ser 
        675                 680                 685             


Phe Pro Asp Thr Arg Ser Ser Thr Cys Ser Ser Gly Glu Asp Ser Val 
    690                 695                 700                 


Phe Ser His Glu Pro Leu Pro Glu Glu Pro Cys Leu Pro Arg His Pro 
705                 710                 715                 720 


Ala Gln Leu Ala Asn Gly Gly Leu Lys Arg Arg 
                725                 730     


<210>  4978
<211>  822
<212>  PRT
<213>  Homo sapiens

<400>  4978

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          


Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly 
        35                  40                  45              


Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  


Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg 
65                  70                  75                  80  


Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser 
                85                  90                  95      


Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr 
            100                 105                 110         


Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
        115                 120                 125             


Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
    130                 135                 140                 


Lys Pro Asn Arg Met Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
145                 150                 155                 160 


Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
                165                 170                 175     


Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
            180                 185                 190         


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
        195                 200                 205             


Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
    210                 215                 220                 


Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
225                 230                 235                 240 


His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
                245                 250                 255     


Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
            260                 265                 270         


Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
        275                 280                 285             


Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
    290                 295                 300                 


Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp 
305                 310                 315                 320 


Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala 
                325                 330                 335     


Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His 
            340                 345                 350         


Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val 
        355                 360                 365             


Met Thr Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala 
    370                 375                 380                 


Phe Leu Ile Ser Cys Met Val Gly Ser Val Ile Val Tyr Lys Met Lys 
385                 390                 395                 400 


Ser Gly Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys 
                405                 410                 415     


Leu Ala Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Asp 
            420                 425                 430         


Ser Ser Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg 
        435                 440                 445             


Leu Ser Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu 
    450                 455                 460                 


Leu Pro Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu 
465                 470                 475                 480 


Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu 
                485                 490                 495     


Ala Ile Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala 
            500                 505                 510         


Val Lys Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu 
        515                 520                 525             


Ile Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile 
    530                 535                 540                 


Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile 
545                 550                 555                 560 


Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg 
                565                 570                 575     


Arg Pro Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu 
            580                 585                 590         


Glu Gln Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala 
        595                 600                 605             


Arg Gly Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu 
    610                 615                 620                 


Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala 
625                 630                 635                 640 


Asp Phe Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys 
                645                 650                 655     


Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu 
            660                 665                 670         


Phe Asp Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val 
        675                 680                 685             


Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val 
    690                 695                 700                 


Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp 
705                 710                 715                 720 


Lys Pro Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys 
                725                 730                 735     


Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu 
            740                 745                 750         


Asp Leu Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp 
        755                 760                 765             


Leu Ser Met Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg 
    770                 775                 780                 


Ser Ser Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro 
785                 790                 795                 800 


Leu Pro Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln Leu Ala Asn 
                805                 810                 815     


Gly Gly Leu Lys Arg Arg 
            820         


<210>  4979
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  4979

Met Gly Phe Asn Leu Thr Leu Ala Lys Leu Pro Asn Asn Glu Leu His 
1               5                   10                  15      


Gly Gln Glu Ser His Asn Ser Gly Asn Arg Ser Asp Gly Pro Gly Lys 
            20                  25                  30          


Asn Thr Thr Leu His Asn Glu Phe Asp Thr Ile Val Leu Pro Val Leu 
        35                  40                  45              


Tyr Leu Ile Ile Phe Val Ala Ser Ile Leu Leu Asn Gly Leu Ala Val 
    50                  55                  60                  


Trp Ile Phe Phe His Ile Arg Asn Lys Thr Ser Phe Ile Phe Tyr Leu 
65                  70                  75                  80  


Lys Asn Ile Val Val Ala Asp Leu Ile Met Thr Leu Thr Phe Pro Phe 
                85                  90                  95      


Arg Ile Val His Asp Ala Gly Phe Gly Pro Trp Tyr Phe Lys Phe Ile 
            100                 105                 110         


Leu Cys Arg Tyr Thr Ser Val Leu Phe Tyr Ala Asn Met Tyr Thr Ser 
        115                 120                 125             


Ile Val Phe Leu Gly Leu Ile Ser Ile Asp Arg Tyr Leu Lys Val Val 
    130                 135                 140                 


Lys Pro Phe Gly Asp Ser Arg Met Tyr Ser Ile Thr Phe Thr Lys Val 
145                 150                 155                 160 


Leu Ser Val Cys Val Trp Val Ile Met Ala Val Leu Ser Leu Pro Asn 
                165                 170                 175     


Ile Ile Leu Thr Asn Gly Gln Pro Thr Glu Asp Asn Ile His Asp Cys 
            180                 185                 190         


Ser Lys Leu Lys Ser Pro Leu Gly Val Lys Trp His Thr Ala Val Thr 
        195                 200                 205             


Tyr Val Asn Ser Cys Leu Phe Val Ala Val Leu Val Ile Leu Ile Gly 
    210                 215                 220                 


Cys Tyr Ile Ala Ile Ser Arg Tyr Ile His Lys Ser Ser Arg Gln Phe 
225                 230                 235                 240 


Ile Ser Gln Ser Ser Arg Lys Arg Lys His Asn Gln Ser Ile Arg Val 
                245                 250                 255     


Val Val Ala Val Phe Phe Thr Cys Phe Leu Pro Tyr His Leu Cys Arg 
            260                 265                 270         


Ile Pro Phe Thr Phe Ser His Leu Asp Arg Leu Leu Asp Glu Ser Ala 
        275                 280                 285             


Gln Lys Ile Leu Tyr Tyr Cys Lys Glu Ile Thr Leu Phe Leu Ser Ala 
    290                 295                 300                 


Cys Asn Val Cys Leu Asp Pro Ile Ile Tyr Phe Phe Met Cys Arg Ser 
305                 310                 315                 320 


Phe Ser Arg Arg Leu Phe Lys Lys Ser Asn Ile Arg Thr Arg Ser Glu 
                325                 330                 335     


Ser Ile Arg Ser Leu Gln Ser Val Arg Arg Ser Glu Val Arg Ile Tyr 
            340                 345                 350         


Tyr Asp Tyr Thr Asp Val 
        355             


<210>  4980
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  4980

Met Pro Ser Ala Ile Glu Ala Ile Tyr Ile Ile Leu Ile Ala Gly Glu 
1               5                   10                  15      


Leu Thr Ile Gly Ile Trp Gly Asn Gly Phe Ile Val Leu Val Asn Cys 
            20                  25                  30          


Ile Asp Trp Leu Lys Arg Arg Asp Ile Ser Leu Ile Asp Ile Ile Leu 
        35                  40                  45              


Ile Ser Leu Ala Ile Ser Arg Ile Cys Leu Leu Cys Val Ile Ser Leu 
    50                  55                  60                  


Asp Gly Phe Phe Met Leu Leu Phe Pro Gly Thr Tyr Gly Asn Ser Val 
65                  70                  75                  80  


Leu Val Ser Ile Val Asn Val Val Trp Thr Phe Ala Asn Asn Ser Ser 
                85                  90                  95      


Leu Trp Phe Thr Ser Cys Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala 
            100                 105                 110         


Asn Ile Ser His Pro Phe Phe Phe Trp Leu Lys Leu Lys Ile Asn Lys 
        115                 120                 125             


Val Met Leu Ala Ile Leu Leu Gly Ser Phe Leu Ile Ser Leu Ile Ile 
    130                 135                 140                 


Ser Val Pro Lys Asn Asp Asp Met Trp Tyr His Leu Phe Lys Val Ser 
145                 150                 155                 160 


His Glu Glu Asn Ile Thr Trp Lys Phe Lys Val Ser Lys Ile Pro Gly 
                165                 170                 175     


Thr Phe Lys Gln Leu Thr Leu Asn Leu Gly Val Met Val Pro Phe Ile 
            180                 185                 190         


Leu Cys Leu Ile Ser Phe Phe Leu Leu Leu Phe Ser Leu Val Arg His 
        195                 200                 205             


Thr Lys Gln Ile Arg Leu His Ala Thr Gly Phe Arg Asp Pro Ser Thr 
    210                 215                 220                 


Glu Ala His Met Arg Ala Ile Lys Ala Val Ile Ile Phe Leu Leu Leu 
225                 230                 235                 240 


Leu Ile Val Tyr Tyr Pro Val Phe Leu Val Met Thr Ser Ser Ala Leu 
                245                 250                 255     


Ile Pro Gln Gly Lys Leu Val Leu Met Ile Gly Asp Ile Val Thr Val 
            260                 265                 270         


Ile Phe Pro Ser Ser His Ser Phe Ile Leu Ile Met Gly Asn Ser Lys 
        275                 280                 285             


Leu Arg Glu Ala Phe Leu Lys Met Leu Arg Phe Val Lys Cys Phe Leu 
    290                 295                 300                 


Arg Arg Arg Lys Pro Phe Val Pro 
305                 310         


<210>  4981
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  4981

Met Phe Ser Pro Ala Asp Asn Ile Phe Ile Ile Leu Ile Thr Gly Glu 
1               5                   10                  15      


Phe Ile Leu Gly Ile Leu Gly Asn Gly Tyr Ile Ala Leu Val Asn Trp 
            20                  25                  30          


Ile Asp Trp Ile Lys Lys Lys Lys Ile Ser Thr Val Asp Tyr Ile Leu 
        35                  40                  45              


Thr Asn Leu Val Ile Ala Arg Ile Cys Leu Ile Ser Val Met Val Val 
    50                  55                  60                  


Asn Gly Ile Val Ile Val Leu Asn Pro Asp Val Tyr Thr Lys Asn Lys 
65                  70                  75                  80  


Gln Gln Ile Val Ile Phe Thr Phe Trp Thr Phe Ala Asn Tyr Leu Asn 
                85                  90                  95      


Met Trp Ile Thr Thr Cys Leu Asn Val Phe Tyr Phe Leu Lys Ile Ala 
            100                 105                 110         


Ser Ser Ser His Pro Leu Phe Leu Trp Leu Lys Trp Lys Ile Asp Met 
        115                 120                 125             


Val Val His Trp Ile Leu Leu Gly Cys Phe Ala Ile Ser Leu Leu Val 
    130                 135                 140                 


Ser Leu Ile Ala Ala Ile Val Leu Ser Cys Asp Tyr Arg Phe His Ala 
145                 150                 155                 160 


Ile Ala Lys His Lys Arg Asn Ile Thr Glu Met Phe His Val Ser Lys 
                165                 170                 175     


Ile Pro Tyr Phe Glu Pro Leu Thr Leu Phe Asn Leu Phe Ala Ile Val 
            180                 185                 190         


Pro Phe Ile Val Ser Leu Ile Ser Phe Phe Leu Leu Val Arg Ser Leu 
        195                 200                 205             


Trp Arg His Thr Lys Gln Ile Lys Leu Tyr Ala Thr Gly Ser Arg Asp 
    210                 215                 220                 


Pro Ser Thr Glu Val His Val Arg Ala Ile Lys Thr Met Thr Ser Phe 
225                 230                 235                 240 


Ile Phe Phe Phe Phe Leu Tyr Tyr Ile Ser Ser Ile Leu Met Thr Phe 
                245                 250                 255     


Ser Tyr Leu Met Thr Lys Tyr Lys Leu Ala Val Glu Phe Gly Glu Ile 
            260                 265                 270         


Ala Ala Ile Leu Tyr Pro Leu Gly His Ser Leu Ile Leu Ile Val Leu 
        275                 280                 285             


Asn Asn Lys Leu Arg Gln Thr Phe Val Arg Met Leu Thr Cys Arg Lys 
    290                 295                 300                 


Ile Ala Cys Met Ile 
305                 


<210>  4982
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  4982

Met Ala Asp Lys Val Gln Thr Thr Leu Leu Phe Leu Ala Val Gly Glu 
1               5                   10                  15      


Phe Ser Val Gly Ile Leu Gly Asn Ala Phe Ile Gly Leu Val Asn Cys 
            20                  25                  30          


Met Asp Trp Val Lys Lys Arg Lys Ile Ala Ser Ile Asp Leu Ile Leu 
        35                  40                  45              


Thr Ser Leu Ala Ile Ser Arg Ile Cys Leu Leu Cys Val Ile Leu Leu 
    50                  55                  60                  


Asp Cys Phe Ile Leu Val Leu Tyr Pro Asp Val Tyr Ala Thr Gly Lys 
65                  70                  75                  80  


Glu Met Arg Ile Ile Asp Phe Phe Trp Thr Leu Thr Asn His Leu Ser 
                85                  90                  95      


Ile Trp Phe Ala Thr Cys Leu Ser Ile Tyr Tyr Phe Phe Lys Ile Gly 
            100                 105                 110         


Asn Phe Phe His Pro Leu Phe Leu Trp Met Lys Trp Arg Ile Asp Arg 
        115                 120                 125             


Val Ile Ser Trp Ile Leu Leu Gly Cys Val Val Leu Ser Val Phe Ile 
    130                 135                 140                 


Ser Leu Pro Ala Thr Glu Asn Leu Asn Ala Asp Phe Arg Phe Cys Val 
145                 150                 155                 160 


Lys Ala Lys Arg Lys Thr Asn Leu Thr Trp Ser Cys Arg Val Asn Lys 
                165                 170                 175     


Thr Gln His Ala Ser Thr Lys Leu Phe Leu Asn Leu Ala Thr Leu Leu 
            180                 185                 190         


Pro Phe Cys Val Cys Leu Met Ser Phe Phe Leu Leu Ile Leu Ser Leu 
        195                 200                 205             


Arg Arg His Ile Arg Arg Met Gln Leu Ser Ala Thr Gly Cys Arg Asp 
    210                 215                 220                 


Pro Ser Thr Glu Ala His Val Arg Ala Leu Lys Ala Val Ile Ser Phe 
225                 230                 235                 240 


Leu Leu Leu Phe Ile Ala Tyr Tyr Leu Ser Phe Leu Ile Ala Thr Ser 
                245                 250                 255     


Ser Tyr Phe Met Pro Glu Thr Glu Leu Ala Val Ile Phe Gly Glu Ser 
            260                 265                 270         


Ile Ala Leu Ile Tyr Pro Ser Ser His Ser Phe Ile Leu Ile Leu Gly 
        275                 280                 285             


Asn Asn Lys Leu Arg His Ala Ser Leu Lys Val Ile Trp Lys Val Met 
    290                 295                 300                 


Ser Ile Leu Lys Gly Arg Lys Phe Gln Gln His Lys Gln Ile 
305                 310                 315             


<210>  4983
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  4983

Met Glu Ser Ala Leu Pro Ser Ile Phe Thr Leu Val Ile Ile Ala Glu 
1               5                   10                  15      


Phe Ile Ile Gly Asn Leu Ser Asn Gly Phe Ile Val Leu Ile Asn Cys 
            20                  25                  30          


Ile Asp Trp Val Ser Lys Arg Glu Leu Ser Ser Val Asp Lys Leu Leu 
        35                  40                  45              


Ile Ile Leu Ala Ile Ser Arg Ile Gly Leu Ile Trp Glu Ile Leu Val 
    50                  55                  60                  


Ser Trp Phe Leu Ala Leu His Tyr Leu Ala Ile Phe Val Ser Gly Thr 
65                  70                  75                  80  


Gly Leu Arg Ile Met Ile Phe Ser Trp Ile Val Ser Asn His Phe Asn 
                85                  90                  95      


Leu Trp Leu Ala Thr Ile Phe Ser Ile Phe Tyr Leu Leu Lys Ile Ala 
            100                 105                 110         


Ser Phe Ser Ser Pro Ala Phe Leu Tyr Leu Lys Trp Arg Val Asn Lys 
        115                 120                 125             


Val Ile Leu Met Ile Leu Leu Gly Thr Leu Val Phe Leu Phe Leu Asn 
    130                 135                 140                 


Leu Ile Gln Ile Asn Met His Ile Lys Asp Trp Leu Asp Arg Tyr Glu 
145                 150                 155                 160 


Arg Asn Thr Thr Trp Asn Phe Ser Met Ser Asp Phe Glu Thr Phe Ser 
                165                 170                 175     


Val Ser Val Lys Phe Thr Met Thr Met Phe Ser Leu Thr Pro Phe Thr 
            180                 185                 190         


Val Ala Phe Ile Ser Phe Leu Leu Leu Ile Phe Ser Leu Gln Lys His 
        195                 200                 205             


Leu Gln Lys Met Gln Leu Asn Tyr Lys Gly His Arg Asp Pro Arg Thr 
    210                 215                 220                 


Lys Val His Thr Asn Ala Leu Lys Ile Val Ile Ser Phe Leu Leu Phe 
225                 230                 235                 240 


Tyr Ala Ser Phe Phe Leu Cys Val Leu Ile Ser Trp Ile Ser Glu Leu 
                245                 250                 255     


Tyr Gln Asn Thr Val Ile Tyr Met Leu Cys Glu Thr Ile Gly Val Phe 
            260                 265                 270         


Ser Pro Ser Ser His Ser Phe Leu Leu Ile Leu Gly Asn Ala Lys Leu 
        275                 280                 285             


Arg Gln Ala Phe Leu Leu Val Ala Ala Lys Val Trp Ala Lys Arg 
    290                 295                 300             


<210>  4984
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  4984

Met Gly Gly Val Ile Lys Ser Ile Phe Thr Phe Val Leu Ile Val Glu 
1               5                   10                  15      


Phe Ile Ile Gly Asn Leu Gly Asn Ser Phe Ile Ala Leu Val Asn Cys 
            20                  25                  30          


Ile Asp Trp Val Lys Gly Arg Lys Ile Ser Ser Val Asp Arg Ile Leu 
        35                  40                  45              


Thr Ala Leu Ala Ile Ser Arg Ile Ser Leu Val Trp Leu Ile Phe Gly 
    50                  55                  60                  


Ser Trp Cys Val Ser Val Phe Phe Pro Ala Leu Phe Ala Thr Glu Lys 
65                  70                  75                  80  


Met Phe Arg Met Leu Thr Asn Ile Trp Thr Val Ile Asn His Phe Ser 
                85                  90                  95      


Val Trp Leu Ala Thr Gly Leu Gly Thr Phe Tyr Phe Leu Lys Ile Ala 
            100                 105                 110         


Asn Phe Ser Asn Ser Ile Phe Leu Tyr Leu Lys Trp Arg Val Lys Lys 
        115                 120                 125             


Val Val Leu Val Leu Leu Leu Val Thr Ser Val Phe Leu Phe Leu Asn 
    130                 135                 140                 


Ile Ala Leu Ile Asn Ile His Ile Asn Ala Ser Ile Asn Gly Tyr Arg 
145                 150                 155                 160 


Arg Asn Lys Thr Cys Ser Ser Asp Ser Ser Asn Phe Thr Arg Phe Ser 
                165                 170                 175     


Ser Leu Ile Val Leu Thr Ser Thr Val Phe Ile Phe Ile Pro Phe Thr 
            180                 185                 190         


Leu Ser Leu Ala Met Phe Leu Leu Leu Ile Phe Ser Met Trp Lys His 
        195                 200                 205             


Arg Lys Lys Met Gln His Thr Val Lys Ile Ser Gly Asp Ala Ser Thr 
    210                 215                 220                 


Lys Ala His Arg Gly Val Lys Ser Val Ile Thr Phe Phe Leu Leu Tyr 
225                 230                 235                 240 


Ala Ile Phe Ser Leu Ser Phe Phe Ile Ser Val Trp Thr Ser Glu Arg 
                245                 250                 255     


Leu Glu Glu Asn Leu Ile Ile Leu Ser Gln Val Met Gly Met Ala Tyr 
            260                 265                 270         


Pro Ser Cys His Ser Cys Val Leu Ile Leu Gly Asn Lys Lys Leu Arg 
        275                 280                 285             


Gln Ala Ser Leu Ser Val Leu Leu Trp Leu Arg Tyr Met Phe Lys Asp 
    290                 295                 300                 


Gly Glu Pro Ser Gly His Lys Glu Phe Arg Glu Ser Ser 
305                 310                 315         


<210>  4985
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  4985

Met Thr Glu Leu Gln Gln Asp Val Glu Asp Thr Lys Pro Ala Lys Val 
1               5                   10                  15      


Leu Gly Lys Arg Glu Ser Lys Leu Gly Ser Ala His Ser Glu Ala Glu 
            20                  25                  30          


Asn Gly Val Glu Glu Lys Lys Lys Ala Cys Arg Ser Pro Thr Ala Gln 
        35                  40                  45              


Ser Pro Thr Pro Ser Val Glu Ala Asp Ser Pro Asp Gln Lys Lys Ile 
    50                  55                  60                  


Ile Ser Leu Trp Ser Lys Ser Ser Phe Asp Gly Ala Ser Leu Ala Ser 
65                  70                  75                  80  


Asp Lys Asn Asp Cys Lys Thr Glu Ser Lys Asn Asp Pro Lys Thr Glu 
                85                  90                  95      


Arg Lys Lys Ser Ser Ser Ser Ser Gln Tyr Lys Ala Asn Met His Phe 
            100                 105                 110         


His Lys Leu Phe Leu Ser Val Pro Thr Glu Glu Pro Leu Lys Gln Ser 
        115                 120                 125             


Phe Thr Cys Ala Leu Gln Lys Glu Ile Leu Tyr Gln Gly Lys Leu Phe 
    130                 135                 140                 


Val Ser Glu Asn Trp Ile Cys Phe His Ser Lys Val Phe Gly Lys Asp 
145                 150                 155                 160 


Thr Lys Ile Ser Ile Pro Ala Phe Ser Val Thr Leu Ile Lys Lys Thr 
                165                 170                 175     


Lys Thr Ala Leu Leu Val Pro Asn Ala Leu Ile Ile Ala Thr Val Thr 
            180                 185                 190         


Asp Arg Tyr Ile Phe Val Ser Leu Leu Ser Arg Asp Ser Thr Tyr Lys 
        195                 200                 205             


Leu Leu Lys Ser Val Cys Gly His Leu Glu Asn Thr Ser Val Gly Asn 
    210                 215                 220                 


Ser Pro Asn Pro Ser Ser Ala Glu Asn Ser Phe Arg Ala Asp Arg Pro 
225                 230                 235                 240 


Ser Ser Leu Pro Leu Asp Phe Asn Asp Glu Phe Ser Asp Leu Asp Gly 
                245                 250                 255     


Val Val Gln Gln Arg Arg Gln Asp Met Glu Gly Tyr Ser Ser Ser Gly 
            260                 265                 270         


Ser Gln Thr Pro Glu Ser Glu Asn Ser Arg Asp Phe His Ala Thr Glu 
        275                 280                 285             


Ser Gln Thr Val Leu Asn Val Ser Lys Gly Glu Ala Lys Pro Thr Arg 
    290                 295                 300                 


Ala Asp Ala His Val Asn Arg Val Pro Glu Gly Lys Ala Lys Ser Leu 
305                 310                 315                 320 


Pro Val Gln Gly Leu Ser Glu Thr Val Gly Ile Leu His Lys Val Lys 
                325                 330                 335     


Ser Gln Lys Cys Pro Met Leu His His Ile Leu Ile Phe Tyr Ala Ile 
            340                 345                 350         


Val Val Cys Ala Leu Ile Ile Ser Thr Phe Tyr Met Arg Tyr Arg Ile 
        355                 360                 365             


Asn Thr Leu Glu Glu Gln Leu Gly Leu Leu Thr Ser Ile Val Asp Thr 
    370                 375                 380                 


His Asn Thr Glu Gln Ala Ala Pro Ser Gly Leu Arg Ser Gln Val Gln 
385                 390                 395                 400 


Phe Asn Val Glu Val Leu Cys Gln Glu Leu Thr Ala Asn Ile Val Lys 
                405                 410                 415     


Leu Glu Lys Ile Gln Asn Asn Leu Gln Lys Leu Leu Glu Asn Gly Asp 
            420                 425                 430         


<210>  4986
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  4986

Met Pro Ser Gly Cys Arg Cys Leu His Leu Val Cys Leu Leu Cys Ile 
1               5                   10                  15      


Leu Gly Ala Pro Gly Gln Pro Val Arg Ala Asp Asp Cys Ser Ser His 
            20                  25                  30          


Cys Asp Leu Ala His Gly Cys Cys Ala Pro Asp Gly Ser Cys Arg Cys 
        35                  40                  45              


Asp Pro Gly Trp Glu Gly Leu His Cys Glu Arg Cys Val Arg Met Pro 
    50                  55                  60                  


Gly Cys Gln His Gly Thr Cys His Gln Pro Trp Gln Cys Ile Cys His 
65                  70                  75                  80  


Ser Gly Trp Ala Gly Lys Phe Cys Asp Lys Asp Glu His Ile Cys Thr 
                85                  90                  95      


Thr Gln Ser Pro Cys Gln Asn Gly Gly Gln Cys Met Tyr Asp Gly Gly 
            100                 105                 110         


Gly Glu Tyr His Cys Val Cys Leu Pro Gly Phe His Gly Arg Asp Cys 
        115                 120                 125             


Glu Arg Lys Ala Gly Pro Cys Glu Gln Ala Gly Ser Pro Cys Arg Asn 
    130                 135                 140                 


Gly Gly Gln Cys Gln Asp Asp Gln Gly Phe Ala Leu Asn Phe Thr Cys 
145                 150                 155                 160 


Arg Cys Leu Val Gly Phe Val Gly Ala Arg Cys Glu Val Asn Val Asp 
                165                 170                 175     


Asp Cys Leu Met Arg Pro Cys Ala Asn Gly Ala Thr Cys Leu Asp Gly 
            180                 185                 190         


Ile Asn Arg Phe Ser Cys Leu Cys Pro Glu Gly Phe Ala Gly Arg Phe 
        195                 200                 205             


Cys Thr Ile Asn Leu Asp Asp Cys Ala Ser Arg Pro Cys Gln Arg Gly 
    210                 215                 220                 


Ala Arg Cys Arg Asp Arg Val His Asp Phe Asp Cys Leu Cys Pro Ser 
225                 230                 235                 240 


Gly Tyr Gly Gly Lys Thr Cys Glu Leu Val Leu Pro Val Pro Asp Pro 
                245                 250                 255     


Pro Thr Thr Val Asp Thr Pro Leu Gly Pro Thr Ser Ala Val Val Val 
            260                 265                 270         


Pro Ala Thr Gly Pro Ala Pro His Ser Ala Gly Ala Gly Leu Leu Arg 
        275                 280                 285             


Ile Ser Val Lys Glu Val Val Arg Arg Gln Glu Ala Gly Leu Gly Glu 
    290                 295                 300                 


Pro Ser Leu Val Ala Leu Val Val Phe Gly Ala Leu Thr Ala Ala Leu 
305                 310                 315                 320 


Val Leu Ala Thr Val Leu Leu Thr Leu Arg Ala Trp Arg Arg Gly Val 
                325                 330                 335     


Cys Pro Pro Gly Pro Cys Cys Tyr Pro Ala Pro His Tyr Ala Pro Ala 
            340                 345                 350         


Cys Gln Asp Gln Glu Cys Gln Val Ser Met Leu Pro Ala Gly Leu Pro 
        355                 360                 365             


Leu Pro Arg Asp Leu Pro Pro Glu Pro Gly Lys Thr Thr Ala Leu 
    370                 375                 380             


<210>  4987
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  4987

Met Ser Leu Leu Ser Leu Pro Trp Leu Gly Leu Arg Pro Val Ala Thr 
1               5                   10                  15      


Ser Pro Trp Leu Leu Leu Leu Leu Val Val Gly Ser Trp Leu Leu Ala 
            20                  25                  30          


Arg Ile Leu Ala Trp Thr Tyr Ala Phe Tyr Asn Asn Cys Arg Arg Leu 
        35                  40                  45              


Gln Cys Phe Pro Gln Pro Pro Lys Arg Asn Trp Phe Trp Gly His Leu 
    50                  55                  60                  


Gly Leu Ile Thr Pro Thr Glu Glu Gly Leu Lys Asn Ser Thr Gln Met 
65                  70                  75                  80  


Ser Ala Thr Tyr Ser Gln Gly Phe Thr Val Trp Leu Gly Pro Ile Ile 
                85                  90                  95      


Pro Phe Ile Val Leu Cys His Pro Asp Thr Ile Arg Ser Ile Thr Asn 
            100                 105                 110         


Ala Ser Ala Ala Ile Ala Pro Lys Asp Asn Leu Phe Ile Arg Phe Leu 
        115                 120                 125             


Lys Pro Trp Leu Gly Glu Gly Ile Leu Leu Ser Gly Gly Asp Lys Trp 
    130                 135                 140                 


Ser Arg His Arg Arg Met Leu Thr Pro Ala Phe His Phe Asn Ile Leu 
145                 150                 155                 160 


Lys Ser Tyr Ile Thr Ile Phe Asn Lys Ser Ala Asn Ile Met Leu Asp 
                165                 170                 175     


Lys Trp Gln His Leu Ala Ser Glu Gly Ser Ser Arg Leu Asp Met Phe 
            180                 185                 190         


Glu His Ile Ser Leu Met Thr Leu Asp Ser Leu Gln Lys Cys Ile Phe 
        195                 200                 205             


Ser Phe Asp Ser His Cys Gln Glu Arg Pro Ser Glu Tyr Ile Ala Thr 
    210                 215                 220                 


Ile Leu Glu Leu Ser Ala Leu Val Glu Lys Arg Ser Gln His Ile Leu 
225                 230                 235                 240 


Gln His Met Asp Phe Leu Tyr Tyr Leu Ser His Asp Gly Arg Arg Phe 
                245                 250                 255     


His Arg Ala Cys Arg Leu Val His Asp Phe Thr Asp Ala Val Ile Arg 
            260                 265                 270         


Glu Arg Arg Arg Thr Leu Pro Thr Gln Gly Ile Asp Asp Phe Phe Lys 
        275                 280                 285             


Asp Lys Ala Lys Ser Lys Thr Leu Asp Phe Ile Asp Val Leu Leu Leu 
    290                 295                 300                 


Ser Lys Asp Glu Asp Gly Lys Ala Leu Ser Asp Glu Asp Ile Arg Ala 
305                 310                 315                 320 


Glu Ala Asp Thr Phe Met Phe Gly Gly His Asp Thr Thr Ala Ser Gly 
                325                 330                 335     


Leu Ser Trp Val Leu Tyr Asn Leu Ala Arg His Pro Glu Tyr Gln Glu 
            340                 345                 350         


Arg Cys Arg Gln Glu Val Gln Glu Leu Leu Lys Asp Arg Asp Pro Lys 
        355                 360                 365             


Glu Ile Glu Trp Asp Asp Leu Ala Gln Leu Pro Phe Leu Thr Met Cys 
    370                 375                 380                 


Val Lys Glu Ser Leu Arg Leu His Pro Pro Ala Pro Phe Ile Ser Arg 
385                 390                 395                 400 


Cys Cys Thr Gln Asp Ile Val Leu Pro Asp Gly Arg Val Ile Pro Lys 
                405                 410                 415     


Gly Ile Thr Cys Leu Ile Asp Ile Ile Gly Val His His Asn Pro Thr 
            420                 425                 430         


Val Trp Pro Asp Pro Glu Val Tyr Asp Pro Phe Arg Phe Asp Pro Glu 
        435                 440                 445             


Asn Ser Lys Gly Arg Ser Pro Leu Ala Phe Ile Pro Phe Ser Ala Gly 
    450                 455                 460                 


Pro Arg Asn Cys Ile Gly Gln Ala Phe Ala Met Ala Glu Met Lys Val 
465                 470                 475                 480 


Val Leu Ala Leu Met Leu Leu His Phe Arg Phe Leu Pro Asp His Thr 
                485                 490                 495     


Glu Pro Arg Arg Lys Leu Glu Leu Ile Met Arg Ala Glu Gly Gly Leu 
            500                 505                 510         


Trp Leu Arg Val Glu Pro Leu Asn Val Ser Leu Gln 
        515                 520                 


<210>  4988
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  4988

Met Asp Ser Ser Thr Ala His Ser Pro Val Phe Leu Val Phe Pro Pro 
1               5                   10                  15      


Glu Ile Thr Ala Ser Glu Tyr Glu Ser Thr Glu Leu Ser Ala Thr Thr 
            20                  25                  30          


Phe Ser Thr Gln Ser Pro Leu Gln Lys Leu Phe Ala Arg Lys Met Lys 
        35                  40                  45              


Ile Leu Gly Thr Ile Gln Ile Leu Phe Gly Ile Met Thr Phe Ser Phe 
    50                  55                  60                  


Gly Val Ile Phe Leu Phe Thr Leu Leu Lys Pro Tyr Pro Arg Phe Pro 
65                  70                  75                  80  


Phe Ile Phe Leu Ser Gly Tyr Pro Phe Trp Gly Ser Val Leu Phe Ile 
                85                  90                  95      


Asn Ser Gly Ala Phe Leu Ile Ala Val Lys Arg Lys Thr Thr Glu Thr 
            100                 105                 110         


Leu Ile Ile Leu Ser Arg Ile Met Asn Phe Leu Ser Ala Leu Gly Ala 
        115                 120                 125             


Ile Ala Gly Ile Ile Leu Leu Thr Phe Gly Phe Ile Leu Asp Gln Asn 
    130                 135                 140                 


Tyr Ile Cys Gly Tyr Ser His Gln Asn Ser Gln Cys Lys Ala Val Thr 
145                 150                 155                 160 


Val Leu Phe Leu Gly Ile Leu Ile Thr Leu Met Thr Phe Ser Ile Ile 
                165                 170                 175     


Glu Leu Phe Ile Ser Leu Pro Phe Ser Ile Leu Gly Cys His Ser Glu 
            180                 185                 190         


Asp Cys Asp Cys Glu Gln Cys Cys 
        195                 200 


<210>  4989
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  4989

Met Arg Arg Gly Ala Pro Gln Asp Gln Glu Leu Val Gly Pro Gly Pro 
1               5                   10                  15      


Pro Gly Arg Gly Ser Arg Gly Ala Pro Pro Pro Leu Gly Pro Val Val 
            20                  25                  30          


Pro Val Leu Val Phe Pro Pro Asp Leu Val Phe Arg Ala Asp Gln Arg 
        35                  40                  45              


Ser Gly Pro Arg Gln Leu Leu Thr Leu Tyr Asn Pro Thr Gly Thr Ala 
    50                  55                  60                  


Leu Arg Phe Arg Val Leu Cys Thr Ala Pro Ala Lys Tyr Thr Val Phe 
65                  70                  75                  80  


Asp Ala Glu Gly Tyr Val Lys Pro Gln Ser Cys Ile Asp Ile Val Ile 
                85                  90                  95      


Arg His Val Ala Pro Ile Pro Ser His Tyr Asp Val Gln Asp Arg Phe 
            100                 105                 110         


Arg Ile Glu Leu Ser Glu Glu Gly Ala Glu Gly Arg Val Val Gly Arg 
        115                 120                 125             


Lys Asp Ile Thr Ser Ile Leu Arg Ala Pro Ala Tyr Pro Leu Glu Leu 
    130                 135                 140                 


Gln Gly Gln Pro Asp Pro Ala Pro Arg Pro Gly Pro Pro Ala Gly Thr 
145                 150                 155                 160 


Pro Pro Pro Thr Ala Arg His Phe Gln Glu His Pro Arg Gln Gln Leu 
                165                 170                 175     


Ala Thr Ser Ser Phe Leu Leu Phe Leu Leu Thr Gly Ile Val Ser Val 
            180                 185                 190         


Ala Phe Leu Leu Leu Pro Leu Pro Asp Glu Leu Gly Ser Gln Leu Pro 
        195                 200                 205             


Gln Val Leu His Val Ser Leu Gly Gln Lys Leu Val Ala Ala Tyr Val 
    210                 215                 220                 


Leu Gly Leu Leu Thr Met Val Phe Leu Arg Thr 
225                 230                 235 


<210>  4990
<211>  1253
<212>  PRT
<213>  Homo sapiens

<400>  4990

Met Val Val Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro 
1               5                   10                  15      


Cys Leu Leu Ile Gln Ile Pro Glu Glu Tyr Glu Gly His His Val Met 
            20                  25                  30          


Glu Pro Pro Val Ile Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe 
        35                  40                  45              


Pro Thr Asp Asp Ile Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu 
    50                  55                  60                  


Val Gln Phe Arg Trp Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu 
65                  70                  75                  80  


Glu Leu Gly Val Thr Val Tyr Gln Ser Pro His Ser Gly Ser Phe Thr 
                85                  90                  95      


Ile Thr Gly Asn Asn Ser Asn Phe Ala Gln Arg Phe Gln Gly Ile Tyr 
            100                 105                 110         


Arg Cys Phe Ala Ser Asn Lys Leu Gly Thr Ala Met Ser His Glu Ile 
        115                 120                 125             


Arg Leu Met Ala Glu Gly Ala Pro Lys Trp Pro Lys Glu Thr Val Lys 
    130                 135                 140                 


Pro Val Glu Val Glu Glu Gly Glu Ser Val Val Leu Pro Cys Asn Pro 
145                 150                 155                 160 


Pro Pro Ser Ala Glu Pro Leu Arg Ile Tyr Trp Met Asn Ser Lys Ile 
                165                 170                 175     


Leu His Ile Lys Gln Asp Glu Arg Val Thr Met Gly Gln Asn Gly Asn 
            180                 185                 190         


Leu Tyr Phe Ala Asn Val Leu Thr Ser Asp Asn His Ser Asp Tyr Ile 
        195                 200                 205             


Cys His Ala His Phe Pro Gly Thr Arg Thr Ile Ile Gln Lys Glu Pro 
    210                 215                 220                 


Ile Asp Leu Arg Val Lys Ala Thr Asn Ser Met Ile Asp Arg Lys Pro 
225                 230                 235                 240 


Arg Leu Leu Phe Pro Thr Asn Ser Ser Ser His Leu Val Ala Leu Gln 
                245                 250                 255     


Gly Gln Pro Leu Val Leu Glu Cys Ile Ala Glu Gly Phe Pro Thr Pro 
            260                 265                 270         


Thr Ile Lys Trp Leu Arg Pro Ser Gly Pro Met Pro Ala Asp Arg Val 
        275                 280                 285             


Thr Tyr Gln Asn His Asn Lys Thr Leu Gln Leu Leu Lys Val Gly Glu 
    290                 295                 300                 


Glu Asp Asp Gly Glu Tyr Arg Cys Leu Ala Glu Asn Ser Leu Gly Ser 
305                 310                 315                 320 


Ala Arg His Ala Tyr Tyr Val Thr Val Glu Ala Ala Pro Tyr Trp Leu 
                325                 330                 335     


His Lys Pro Gln Ser His Leu Tyr Gly Pro Gly Glu Thr Ala Arg Leu 
            340                 345                 350         


Asp Cys Gln Val Gln Gly Arg Pro Gln Pro Glu Val Thr Trp Arg Ile 
        355                 360                 365             


Asn Gly Ile Pro Val Glu Glu Leu Ala Lys Asp Gln Lys Tyr Arg Ile 
    370                 375                 380                 


Gln Arg Gly Ala Leu Ile Leu Ser Asn Val Gln Pro Ser Asp Thr Met 
385                 390                 395                 400 


Val Thr Gln Cys Glu Ala Arg Asn Arg His Gly Leu Leu Leu Ala Asn 
                405                 410                 415     


Ala Tyr Ile Tyr Val Val Gln Leu Pro Ala Lys Ile Leu Thr Ala Asp 
            420                 425                 430         


Asn Gln Thr Tyr Met Ala Val Gln Gly Ser Thr Ala Tyr Leu Leu Cys 
        435                 440                 445             


Lys Ala Phe Gly Ala Pro Val Pro Ser Val Gln Trp Leu Asp Glu Asp 
    450                 455                 460                 


Gly Thr Thr Val Leu Gln Asp Glu Arg Phe Phe Pro Tyr Ala Asn Gly 
465                 470                 475                 480 


Thr Leu Gly Ile Arg Asp Leu Gln Ala Asn Asp Thr Gly Arg Tyr Phe 
                485                 490                 495     


Cys Leu Ala Ala Asn Asp Gln Asn Asn Val Thr Ile Met Ala Asn Leu 
            500                 505                 510         


Lys Val Lys Asp Ala Thr Gln Ile Thr Gln Gly Pro Arg Ser Thr Ile 
        515                 520                 525             


Glu Lys Lys Gly Ser Arg Val Thr Phe Thr Cys Gln Ala Ser Phe Asp 
    530                 535                 540                 


Pro Ser Leu Gln Pro Ser Ile Thr Trp Arg Gly Asp Gly Arg Asp Leu 
545                 550                 555                 560 


Gln Glu Leu Gly Asp Ser Asp Lys Tyr Phe Ile Glu Asp Gly Arg Leu 
                565                 570                 575     


Val Ile His Ser Leu Asp Tyr Ser Asp Gln Gly Asn Tyr Ser Cys Val 
            580                 585                 590         


Ala Ser Thr Glu Leu Asp Val Val Glu Ser Arg Ala Gln Leu Leu Val 
        595                 600                 605             


Val Gly Ser Pro Gly Pro Val Pro Arg Leu Val Leu Ser Asp Leu His 
    610                 615                 620                 


Leu Leu Thr Gln Ser Gln Val Arg Val Ser Trp Ser Pro Ala Glu Asp 
625                 630                 635                 640 


His Asn Ala Pro Ile Glu Lys Tyr Asp Ile Glu Phe Glu Asp Lys Glu 
                645                 650                 655     


Met Ala Pro Glu Lys Trp Tyr Ser Leu Gly Lys Val Pro Gly Asn Gln 
            660                 665                 670         


Thr Ser Thr Thr Leu Lys Leu Ser Pro Tyr Val His Tyr Thr Phe Arg 
        675                 680                 685             


Val Thr Ala Ile Asn Lys Tyr Gly Pro Gly Glu Pro Ser Pro Val Ser 
    690                 695                 700                 


Glu Thr Val Val Thr Pro Glu Ala Ala Pro Glu Lys Asn Pro Val Asp 
705                 710                 715                 720 


Val Lys Gly Glu Gly Asn Glu Thr Thr Asn Met Val Ile Thr Trp Lys 
                725                 730                 735     


Pro Leu Arg Trp Met Asp Trp Asn Ala Pro Gln Val Gln Tyr Arg Val 
            740                 745                 750         


Gln Trp Arg Pro Gln Gly Thr Arg Gly Pro Trp Gln Glu Gln Ile Val 
        755                 760                 765             


Ser Asp Pro Phe Leu Val Val Ser Asn Thr Ser Thr Phe Val Pro Tyr 
    770                 775                 780                 


Glu Ile Lys Val Gln Ala Val Asn Ser Gln Gly Lys Gly Pro Glu Pro 
785                 790                 795                 800 


Gln Val Thr Ile Gly Tyr Ser Gly Glu Asp Tyr Pro Gln Ala Ile Pro 
                805                 810                 815     


Glu Leu Glu Gly Ile Glu Ile Leu Asn Ser Ser Ala Val Leu Val Lys 
            820                 825                 830         


Trp Arg Pro Val Asp Leu Ala Gln Val Lys Gly His Leu Arg Gly Tyr 
        835                 840                 845             


Asn Val Thr Tyr Trp Arg Glu Gly Ser Gln Arg Lys His Ser Lys Arg 
    850                 855                 860                 


His Ile His Lys Asp His Val Val Val Pro Ala Asn Thr Thr Ser Val 
865                 870                 875                 880 


Ile Leu Ser Gly Leu Arg Pro Tyr Ser Ser Tyr His Leu Glu Val Gln 
                885                 890                 895     


Ala Phe Asn Gly Arg Gly Ser Gly Pro Ala Ser Glu Phe Thr Phe Ser 
            900                 905                 910         


Thr Pro Glu Gly Val Pro Gly His Pro Glu Ala Leu His Leu Glu Cys 
        915                 920                 925             


Gln Ser Asn Thr Ser Leu Leu Leu Arg Trp Gln Pro Pro Leu Ser His 
    930                 935                 940                 


Asn Gly Val Leu Thr Gly Tyr Val Leu Ser Tyr His Pro Leu Asp Glu 
945                 950                 955                 960 


Gly Gly Lys Gly Gln Leu Ser Phe Asn Leu Arg Asp Pro Glu Leu Arg 
                965                 970                 975     


Thr His Asn Leu Thr Asp Leu Ser Pro His Leu Arg Tyr Arg Phe Gln 
            980                 985                 990         


Leu Gln Ala Thr Thr Lys Glu Gly  Pro Gly Glu Ala Ile  Val Arg Glu 
        995                 1000                 1005             


Gly Gly  Thr Met Ala Leu Ser  Gly Ile Ser Asp Phe  Gly Asn Ile 
    1010                 1015                 1020             


Ser Ala  Thr Ala Gly Glu Asn  Tyr Ser Val Val Ser  Trp Val Pro 
    1025                 1030                 1035             


Lys Glu  Gly Gln Cys Asn Phe  Arg Phe His Ile Leu  Phe Lys Ala 
    1040                 1045                 1050             


Leu Gly  Glu Glu Lys Gly Gly  Ala Ser Leu Ser Pro  Gln Tyr Val 
    1055                 1060                 1065             


Ser Tyr  Asn Gln Ser Ser Tyr  Thr Gln Trp Asp Leu  Gln Pro Asp 
    1070                 1075                 1080             


Thr Asp  Tyr Glu Ile His Leu  Phe Lys Glu Arg Met  Phe Arg His 
    1085                 1090                 1095             


Gln Met  Ala Val Lys Thr Asn  Gly Thr Gly Arg Val  Arg Leu Pro 
    1100                 1105                 1110             


Pro Ala  Gly Phe Ala Thr Glu  Gly Trp Phe Ile Gly  Phe Val Ser 
    1115                 1120                 1125             


Ala Ile  Ile Leu Leu Leu Leu  Val Leu Leu Ile Leu  Cys Phe Ile 
    1130                 1135                 1140             


Lys Arg  Ser Lys Gly Gly Lys  Tyr Ser Val Lys Asp  Lys Glu Asp 
    1145                 1150                 1155             


Thr Gln  Val Asp Ser Glu Ala  Arg Pro Met Lys Asp  Glu Thr Phe 
    1160                 1165                 1170             


Gly Glu  Tyr Ser Asp Asn Glu  Glu Lys Ala Phe Gly  Ser Ser Gln 
    1175                 1180                 1185             


Pro Ser  Leu Asn Gly Asp Ile  Lys Pro Leu Gly Ser  Asp Asp Ser 
    1190                 1195                 1200             


Leu Ala  Asp Tyr Gly Gly Ser  Val Asp Val Gln Phe  Asn Glu Asp 
    1205                 1210                 1215             


Gly Ser  Phe Ile Gly Gln Tyr  Ser Gly Lys Lys Glu  Lys Glu Ala 
    1220                 1225                 1230             


Ala Gly  Gly Asn Asp Ser Ser  Gly Ala Thr Ser Pro  Ile Asn Pro 
    1235                 1240                 1245             


Ala Val  Ala Leu Glu 
    1250             


<210>  4991
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  4991

Met Gly Ser Thr Trp Gly Ser Pro Gly Trp Val Arg Leu Ala Leu Cys 
1               5                   10                  15      


Leu Thr Gly Leu Val Leu Ser Leu Tyr Ala Leu His Val Lys Ala Ala 
            20                  25                  30          


Arg Ala Arg Asp Arg Asp Tyr Arg Ala Leu Cys Asp Val Gly Thr Ala 
        35                  40                  45              


Ile Ser Cys Ser Arg Val Phe Ser Ser Arg Trp Gly Arg Gly Phe Gly 
    50                  55                  60                  


Leu Val Glu His Val Leu Gly Gln Asp Ser Ile Leu Asn Gln Ser Asn 
65                  70                  75                  80  


Ser Ile Phe Gly Cys Ile Phe Tyr Thr Leu Gln Leu Leu Leu Gly Cys 
                85                  90                  95      


Leu Arg Thr Arg Trp Ala Ser Val Leu Met Leu Leu Ser Ser Leu Val 
            100                 105                 110         


Ser Leu Ala Gly Ser Val Tyr Leu Ala Trp Ile Leu Phe Phe Val Leu 
        115                 120                 125             


Tyr Asp Phe Cys Ile Val Cys Ile Thr Thr Tyr Ala Ile Asn Val Ser 
    130                 135                 140                 


Leu Met Trp Leu Ser Phe Arg Lys Val Gln Glu Pro Gln Gly Lys Ala 
145                 150                 155                 160 


Lys Arg His 
            


<210>  4992
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  4992

Met Asp Trp Lys Thr Leu Gln Ala Leu Leu Ser Gly Val Asn Lys Tyr 
1               5                   10                  15      


Ser Thr Ala Phe Gly Arg Ile Trp Leu Ser Val Val Phe Val Phe Arg 
            20                  25                  30          


Val Leu Val Tyr Val Val Ala Ala Glu Arg Val Trp Gly Asp Glu Gln 
        35                  40                  45              


Lys Asp Phe Asp Cys Asn Thr Lys Gln Pro Gly Cys Thr Asn Val Cys 
    50                  55                  60                  


Tyr Asp Asn Tyr Phe Pro Ile Ser Asn Ile Arg Leu Trp Ala Leu Gln 
65                  70                  75                  80  


Leu Ile Phe Val Thr Cys Pro Ser Leu Leu Val Ile Leu His Val Ala 
                85                  90                  95      


Tyr Arg Glu Glu Arg Glu Arg Arg His Arg Gln Lys His Gly Asp Gln 
            100                 105                 110         


Cys Ala Lys Leu Tyr Asp Asn Ala Gly Lys Lys His Gly Gly Leu Trp 
        115                 120                 125             


Trp Thr Tyr Leu Phe Ser Leu Ile Phe Lys Leu Ile Ile Glu Phe Leu 
    130                 135                 140                 


Phe Leu Tyr Leu Leu His Thr Leu Trp His Gly Phe Asn Met Pro Arg 
145                 150                 155                 160 


Leu Val Gln Cys Ala Asn Val Ala Pro Cys Pro Asn Ile Val Asp Cys 
                165                 170                 175     


Tyr Ile Ala Arg Pro Thr Glu Lys Lys Ile Phe Thr Tyr Phe Met Val 
            180                 185                 190         


Gly Ala Ser Ala Val Cys Ile Val Leu Thr Ile Cys Glu Leu Cys Tyr 
        195                 200                 205             


Leu Ile Cys His Arg Val Leu Arg Gly Leu His Lys Asp Lys Pro Arg 
    210                 215                 220                 


Gly Gly Cys Ser Pro Ser Ser Ser Ala Ser Arg Ala Ser Thr Cys Arg 
225                 230                 235                 240 


Cys His His Lys Leu Val Glu Ala Gly Glu Val Asp Pro Asp Pro Gly 
                245                 250                 255     


Asn Asn Lys Leu Gln Ala Ser Ala Pro Asn Leu Thr Pro Ile 
            260                 265                 270 


<210>  4993
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  4993

Met Asp Leu Pro Val Asn Leu Thr Ser Phe Ser Leu Ser Thr Pro Ser 
1               5                   10                  15      


Pro Leu Glu Thr Asn His Ser Leu Gly Lys Asp Asp Leu Arg Pro Ser 
            20                  25                  30          


Ser Pro Leu Leu Ser Val Phe Gly Val Leu Ile Leu Thr Leu Leu Gly 
        35                  40                  45              


Phe Leu Val Ala Ala Thr Phe Ala Trp Asn Leu Leu Val Leu Ala Thr 
    50                  55                  60                  


Ile Leu Arg Val Arg Thr Phe His Arg Val Pro His Asn Leu Val Ala 
65                  70                  75                  80  


Ser Met Ala Val Ser Asp Val Leu Val Ala Ala Leu Val Met Pro Leu 
                85                  90                  95      


Ser Leu Val His Glu Leu Ser Gly Arg Arg Trp Gln Leu Gly Arg Arg 
            100                 105                 110         


Leu Cys Gln Leu Trp Ile Ala Cys Asp Val Leu Cys Cys Thr Ala Ser 
        115                 120                 125             


Ile Trp Asn Val Thr Ala Ile Ala Leu Asp Arg Tyr Trp Ser Ile Thr 
    130                 135                 140                 


Arg His Met Glu Tyr Thr Leu Arg Thr Arg Lys Cys Val Ser Asn Val 
145                 150                 155                 160 


Met Ile Ala Leu Thr Trp Ala Leu Ser Ala Val Ile Ser Leu Ala Pro 
                165                 170                 175     


Leu Leu Phe Gly Trp Gly Glu Thr Tyr Ser Glu Gly Ser Glu Glu Cys 
            180                 185                 190         


Gln Val Ser Arg Glu Pro Ser Tyr Ala Val Phe Ser Thr Val Gly Ala 
        195                 200                 205             


Phe Tyr Leu Pro Leu Cys Val Val Leu Phe Val Tyr Trp Lys Ile Tyr 
    210                 215                 220                 


Lys Ala Ala Lys Phe Arg Val Gly Ser Arg Lys Thr Asn Ser Val Ser 
225                 230                 235                 240 


Pro Ile Ser Glu Ala Val Glu Val Lys Asp Ser Ala Lys Gln Pro Gln 
                245                 250                 255     


Met Val Phe Thr Val Arg His Ala Thr Val Thr Phe Gln Pro Glu Gly 
            260                 265                 270         


Asp Thr Trp Arg Glu Gln Lys Glu Gln Arg Ala Ala Leu Met Val Gly 
        275                 280                 285             


Ile Leu Ile Gly Val Phe Val Leu Cys Trp Ile Pro Phe Phe Leu Thr 
    290                 295                 300                 


Glu Leu Ile Ser Pro Leu Cys Ser Cys Asp Ile Pro Ala Ile Trp Lys 
305                 310                 315                 320 


Ser Ile Phe Leu Trp Leu Gly Tyr Ser Asn Ser Phe Phe Asn Pro Leu 
                325                 330                 335     


Ile Tyr Thr Ala Phe Asn Lys Asn Tyr Asn Ser Ala Phe Lys Asn Phe 
            340                 345                 350         


Phe Ser Arg Gln His 
        355         


<210>  4994
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  4994

Met Thr Thr Met Gln Gly Met Glu Gln Ala Met Pro Gly Ala Gly Pro 
1               5                   10                  15      


Gly Val Pro Gln Leu Gly Asn Met Ala Val Ile His Ser His Leu Trp 
            20                  25                  30          


Lys Gly Leu Gln Glu Lys Phe Leu Lys Gly Glu Pro Lys Val Leu Gly 
        35                  40                  45              


Val Val Gln Ile Leu Thr Ala Leu Met Ser Leu Ser Met Gly Ile Thr 
    50                  55                  60                  


Met Met Cys Met Ala Ser Asn Thr Tyr Gly Ser Asn Pro Ile Ser Val 
65                  70                  75                  80  


Tyr Ile Gly Tyr Thr Ile Trp Gly Ser Val Met Phe Ile Ile Ser Gly 
                85                  90                  95      


Ser Leu Ser Ile Ala Ala Gly Ile Arg Thr Thr Lys Gly Leu Val Arg 
            100                 105                 110         


Gly Ser Leu Gly Met Asn Ile Thr Ser Ser Val Leu Ala Ala Ser Gly 
        115                 120                 125             


Ile Leu Ile Asn Thr Phe Ser Leu Ala Phe Tyr Ser Phe His His Pro 
    130                 135                 140                 


Tyr Cys Asn Tyr Tyr Gly Asn Ser Asn Asn Cys His Gly Thr Met Ser 
145                 150                 155                 160 


Ile Leu Met Gly Leu Asp Gly Met Val Leu Leu Leu Ser Val Leu Glu 
                165                 170                 175     


Phe Cys Ile Ala Val Ser Leu Ser Ala Phe Gly Cys Lys Val Leu Cys 
            180                 185                 190         


Cys Thr Pro Gly Gly Val Val Leu Ile Leu Pro Ser His Ser His Met 
        195                 200                 205             


Ala Glu Thr Ala Ser Pro Thr Pro Leu Asn Glu Val 
    210                 215                 220 


<210>  4995
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  4995

Met Gly Glu Asn Asp Pro Pro Ala Val Glu Ala Pro Phe Ser Phe Arg 
1               5                   10                  15      


Ser Leu Phe Gly Leu Asp Asp Leu Lys Ile Ser Pro Val Ala Pro Asp 
            20                  25                  30          


Ala Asp Ala Val Ala Ala Gln Ile Leu Ser Leu Leu Pro Leu Lys Phe 
        35                  40                  45              


Phe Pro Ile Ile Val Ile Gly Ile Ile Ala Leu Ile Leu Ala Leu Ala 
    50                  55                  60                  


Ile Gly Leu Gly Ile His Phe Asp Cys Ser Gly Lys Tyr Arg Cys Arg 
65                  70                  75                  80  


Ser Ser Phe Lys Cys Ile Glu Leu Ile Ala Arg Cys Asp Gly Val Ser 
                85                  90                  95      


Asp Cys Lys Asp Gly Glu Asp Glu Tyr Arg Cys Val Arg Val Gly Gly 
            100                 105                 110         


Gln Asn Ala Val Leu Gln Val Phe Thr Ala Ala Ser Trp Lys Thr Met 
        115                 120                 125             


Cys Ser Asp Asp Trp Lys Gly His Tyr Ala Asn Val Ala Cys Ala Gln 
    130                 135                 140                 


Leu Gly Phe Pro Ser Tyr Val Ser Ser Asp Asn Leu Arg Val Ser Ser 
145                 150                 155                 160 


Leu Glu Gly Gln Phe Arg Glu Glu Phe Val Ser Ile Asp His Leu Leu 
                165                 170                 175     


Pro Asp Asp Lys Val Thr Ala Leu His His Ser Val Tyr Val Arg Glu 
            180                 185                 190         


Gly Cys Ala Ser Gly His Val Val Thr Leu Gln Cys Thr Ala Cys Gly 
        195                 200                 205             


His Arg Arg Gly Tyr Ser Ser Arg Ile Val Gly Gly Asn Met Ser Leu 
    210                 215                 220                 


Leu Ser Gln Trp Pro Trp Gln Ala Ser Leu Gln Phe Gln Gly Tyr His 
225                 230                 235                 240 


Leu Cys Gly Gly Ser Val Ile Thr Pro Leu Trp Ile Ile Thr Ala Ala 
                245                 250                 255     


His Cys Val Tyr Asp Leu Tyr Leu Pro Lys Ser Trp Thr Ile Gln Val 
            260                 265                 270         


Gly Leu Val Ser Leu Leu Asp Asn Pro Ala Pro Ser His Leu Val Glu 
        275                 280                 285             


Lys Ile Val Tyr His Ser Lys Tyr Lys Pro Lys Arg Leu Gly Asn Asp 
    290                 295                 300                 


Ile Ala Leu Met Lys Leu Ala Gly Pro Leu Thr Phe Asn Glu Met Ile 
305                 310                 315                 320 


Gln Pro Val Cys Leu Pro Asn Ser Glu Glu Asn Phe Pro Asp Gly Lys 
                325                 330                 335     


Val Cys Trp Thr Ser Gly Trp Gly Ala Thr Glu Asp Gly Ala Gly Asp 
            340                 345                 350         


Ala Ser Pro Val Leu Asn His Ala Ala Val Pro Leu Ile Ser Asn Lys 
        355                 360                 365             


Ile Cys Asn His Arg Asp Val Tyr Gly Gly Ile Ile Ser Pro Ser Met 
    370                 375                 380                 


Leu Cys Ala Gly Tyr Leu Thr Gly Gly Val Asp Ser Cys Gln Gly Asp 
385                 390                 395                 400 


Ser Gly Gly Pro Leu Val Cys Gln Glu Arg Arg Leu Trp Lys Leu Val 
                405                 410                 415     


Gly Ala Thr Ser Phe Gly Ile Gly Cys Ala Glu Val Asn Lys Pro Gly 
            420                 425                 430         


Val Tyr Thr Arg Val Thr Ser Phe Leu Asp Trp Ile His Glu Gln Met 
        435                 440                 445             


Glu Arg Asp Leu Lys Thr 
    450                 


<210>  4996
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  4996

Met Arg Gly Asn Leu Ala Leu Val Gly Val Leu Ile Ser Leu Ala Phe 
1               5                   10                  15      


Leu Ser Leu Leu Pro Ser Gly His Pro Gln Pro Ala Gly Asp Asp Ala 
            20                  25                  30          


Cys Ser Val Gln Ile Leu Val Pro Gly Leu Lys Gly Asp Ala Gly Glu 
        35                  40                  45              


Lys Gly Asp Lys Gly Ala Pro Gly Arg Pro Gly Arg Val Gly Pro Thr 
    50                  55                  60                  


Gly Glu Lys Gly Asp Met Gly Asp Lys Gly Gln Lys Gly Ser Val Gly 
65                  70                  75                  80  


Arg His Gly Lys Ile Gly Pro Ile Gly Ser Lys Gly Glu Lys Gly Asp 
                85                  90                  95      


Ser Gly Asp Ile Gly Pro Pro Gly Pro Asn Gly Glu Pro Gly Leu Pro 
            100                 105                 110         


Cys Glu Cys Ser Gln Leu Arg Lys Ala Ile Gly Glu Met Asp Asn Gln 
        115                 120                 125             


Val Ser Gln Leu Thr Ser Glu Leu Lys Phe Ile Lys Asn Ala Val Ala 
    130                 135                 140                 


Gly Val Arg Glu Thr Glu Ser Lys Ile Tyr Leu Leu Val Lys Glu Glu 
145                 150                 155                 160 


Lys Arg Tyr Ala Asp Ala Gln Leu Ser Cys Gln Gly Arg Gly Gly Thr 
                165                 170                 175     


Leu Ser Met Pro Lys Asp Glu Ala Ala Asn Gly Leu Met Ala Ala Tyr 
            180                 185                 190         


Leu Ala Gln Ala Gly Leu Ala Arg Val Phe Ile Gly Ile Asn Asp Leu 
        195                 200                 205             


Glu Lys Glu Gly Ala Phe Val Tyr Ser Asp His Ser Pro Met Arg Thr 
    210                 215                 220                 


Phe Asn Lys Trp Arg Ser Gly Glu Pro Asn Asn Ala Tyr Asp Glu Glu 
225                 230                 235                 240 


Asp Cys Val Glu Met Val Ala Ser Gly Gly Trp Asn Asp Val Ala Cys 
                245                 250                 255     


His Thr Thr Met Tyr Phe Met Cys Glu Phe Asp Lys Glu Asn Met 
            260                 265                 270     


<210>  4997
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  4997

Met Ala Ser Ala Asp Glu Leu Thr Phe His Glu Phe Glu Glu Ala Thr 
1               5                   10                  15      


Asn Leu Leu Ala Asp Thr Pro Asp Ala Ala Thr Thr Ser Arg Ser Asp 
            20                  25                  30          


Gln Leu Thr Pro Gln Gly His Val Ala Val Ala Val Gly Ser Gly Gly 
        35                  40                  45              


Ser Tyr Gly Ala Glu Asp Glu Val Glu Glu Glu Ser Asp Lys Ala Ala 
    50                  55                  60                  


Leu Leu Gln Glu Gln Gln Gln Gln Gln Gln Pro Gly Phe Trp Thr Phe 
65                  70                  75                  80  


Ser Tyr Tyr Gln Ser Phe Phe Asp Val Asp Thr Ser Gln Val Leu Asp 
                85                  90                  95      


Arg Ile Lys Gly Ser Leu Leu Pro Arg Pro Gly His Asn Phe Val Arg 
            100                 105                 110         


His His Leu Arg Asn Arg Pro Asp Leu Tyr Gly Pro Phe Trp Ile Cys 
        115                 120                 125             


Ala Thr Leu Ala Phe Val Leu Ala Val Thr Gly Asn Leu Thr Leu Val 
    130                 135                 140                 


Leu Ala Gln Arg Arg Asp Pro Ser Ile His Tyr Ser Pro Gln Phe His 
145                 150                 155                 160 


Lys Val Thr Val Ala Gly Ile Ser Ile Tyr Cys Tyr Ala Trp Leu Val 
                165                 170                 175     


Pro Leu Ala Leu Trp Gly Phe Leu Arg Trp Arg Lys Gly Val Gln Glu 
            180                 185                 190         


Arg Met Gly Pro Tyr Thr Phe Leu Glu Thr Val Cys Ile Tyr Gly Tyr 
        195                 200                 205             


Ser Leu Phe Val Phe Ile Pro Met Val Val Leu Trp Leu Ile Pro Val 
    210                 215                 220                 


Pro Trp Leu Gln Trp Leu Phe Gly Ala Leu Ala Leu Gly Leu Ser Ala 
225                 230                 235                 240 


Ala Gly Leu Val Phe Thr Leu Trp Pro Val Val Arg Glu Asp Thr Arg 
                245                 250                 255     


Leu Val Ala Thr Val Leu Leu Ser Val Val Val Leu Leu His Ala Leu 
            260                 265                 270         


Leu Ala Met Gly Cys Lys Leu Tyr Phe Phe Gln Ser Leu Pro Pro Glu 
        275                 280                 285             


Asn Val Ala Pro Pro Pro Gln Ile Thr Ser Leu Pro Ser Asn Ile Ala 
    290                 295                 300                 


Leu Ser Pro Thr Leu Pro Gln Ser Leu Ala Pro Ser 
305                 310                 315     


<210>  4998
<211>  367
<212>  PRT
<213>  Homo sapiens

<400>  4998

Met Ala Thr Pro Asn Asn Leu Thr Pro Thr Asn Cys Ser Trp Trp Pro 
1               5                   10                  15      


Ile Ser Ala Leu Glu Ser Asp Ala Ala Lys Pro Ala Glu Ala Pro Asp 
            20                  25                  30          


Ala Pro Glu Ala Ala Ser Pro Ala His Trp Pro Arg Glu Ser Leu Val 
        35                  40                  45              


Leu Tyr His Trp Thr Gln Ser Phe Ser Ser Gln Lys Val Arg Leu Val 
    50                  55                  60                  


Ile Ala Glu Lys Gly Leu Val Cys Glu Glu Arg Asp Val Ser Leu Pro 
65                  70                  75                  80  


Gln Ser Glu His Lys Glu Pro Trp Phe Met Arg Leu Asn Leu Gly Glu 
                85                  90                  95      


Glu Val Pro Val Ile Ile His Arg Asp Asn Ile Ile Ser Asp Tyr Asp 
            100                 105                 110         


Gln Ile Ile Asp Tyr Val Glu Arg Thr Phe Thr Gly Glu His Val Val 
        115                 120                 125             


Ala Leu Met Pro Glu Val Gly Ser Leu Gln His Ala Arg Val Leu Gln 
    130                 135                 140                 


Tyr Arg Glu Leu Leu Asp Ala Leu Pro Met Asp Ala Tyr Thr His Gly 
145                 150                 155                 160 


Cys Ile Leu His Pro Glu Leu Thr Thr Asp Ser Met Ile Pro Lys Tyr 
                165                 170                 175     


Ala Thr Ala Glu Ile Arg Arg His Leu Ala Asn Ala Thr Thr Asp Leu 
            180                 185                 190         


Met Lys Leu Asp His Glu Glu Glu Pro Gln Leu Ser Glu Pro Tyr Leu 
        195                 200                 205             


Ser Lys Gln Lys Lys Leu Met Ala Lys Ile Leu Glu His Asp Asp Val 
    210                 215                 220                 


Ser Tyr Leu Lys Lys Ile Leu Gly Glu Leu Ala Met Val Leu Asp Gln 
225                 230                 235                 240 


Ile Glu Ala Glu Leu Glu Lys Arg Lys Leu Glu Asn Glu Gly Gln Lys 
                245                 250                 255     


Cys Glu Leu Trp Leu Cys Gly Cys Ala Phe Thr Leu Ala Asp Val Leu 
            260                 265                 270         


Leu Gly Ala Thr Leu His Arg Leu Lys Phe Leu Gly Leu Ser Lys Lys 
        275                 280                 285             


Tyr Trp Glu Asp Gly Ser Arg Pro Asn Leu Gln Ser Phe Phe Glu Arg 
    290                 295                 300                 


Val Gln Arg Arg Phe Ala Phe Arg Lys Val Leu Gly Asp Ile His Thr 
305                 310                 315                 320 


Thr Leu Leu Ser Ala Val Ile Pro Asn Ala Phe Arg Leu Val Lys Arg 
                325                 330                 335     


Lys Pro Pro Ser Phe Phe Gly Ala Ser Phe Leu Met Gly Ser Leu Gly 
            340                 345                 350         


Gly Met Gly Tyr Phe Ala Tyr Trp Tyr Leu Lys Lys Lys Tyr Ile 
        355                 360                 365         


<210>  4999
<211>  635
<212>  PRT
<213>  Homo sapiens

<400>  4999

Met Ala Pro Pro Leu Leu Leu Leu Leu Leu Ala Ser Gly Ala Ala Ala 
1               5                   10                  15      


Cys Pro Leu Pro Cys Val Cys Gln Asn Leu Ser Glu Ser Leu Ser Thr 
            20                  25                  30          


Leu Cys Ala His Arg Gly Leu Leu Phe Val Pro Pro Asn Val Asp Arg 
        35                  40                  45              


Arg Thr Val Glu Leu Arg Leu Ala Asp Asn Phe Ile Gln Ala Leu Gly 
    50                  55                  60                  


Pro Pro Asp Phe Arg Asn Met Thr Gly Leu Val Asp Leu Thr Leu Ser 
65                  70                  75                  80  


Arg Asn Ala Ile Thr Arg Ile Gly Ala Arg Ala Phe Gly Asp Leu Glu 
                85                  90                  95      


Ser Leu Arg Ser Leu His Leu Asp Gly Asn Arg Leu Val Glu Leu Gly 
            100                 105                 110         


Thr Gly Ser Leu Arg Gly Pro Val Asn Leu Gln His Leu Ile Leu Ser 
        115                 120                 125             


Gly Asn Gln Leu Gly Arg Ile Ala Pro Gly Ala Phe Asp Asp Phe Leu 
    130                 135                 140                 


Glu Ser Leu Glu Asp Leu Asp Leu Ser Tyr Asn Asn Leu Arg Gln Val 
145                 150                 155                 160 


Pro Trp Ala Gly Ile Gly Ala Met Pro Ala Leu His Thr Leu Asn Leu 
                165                 170                 175     


Asp His Asn Leu Ile Asp Ala Leu Pro Pro Gly Ala Phe Ala Gln Leu 
            180                 185                 190         


Gly Gln Leu Ser Arg Leu Asp Leu Thr Ser Asn Arg Leu Ala Thr Leu 
        195                 200                 205             


Ala Pro Asp Pro Leu Phe Ser Arg Gly Arg Asp Ala Glu Ala Ser Pro 
    210                 215                 220                 


Ala Pro Leu Val Leu Ser Phe Ser Gly Asn Pro Leu His Cys Asn Cys 
225                 230                 235                 240 


Glu Leu Leu Trp Leu Arg Arg Leu Ala Arg Pro Asp Asp Leu Glu Thr 
                245                 250                 255     


Cys Ala Ser Pro Pro Gly Leu Ala Gly Arg Tyr Phe Trp Ala Val Pro 
            260                 265                 270         


Glu Gly Glu Phe Ser Cys Glu Pro Pro Leu Ile Ala Arg His Thr Gln 
        275                 280                 285             


Arg Leu Trp Val Leu Glu Gly Gln Arg Ala Thr Leu Arg Cys Arg Ala 
    290                 295                 300                 


Leu Gly Asp Pro Ala Pro Thr Met His Trp Val Gly Pro Asp Asp Arg 
305                 310                 315                 320 


Leu Val Gly Asn Ser Ser Arg Ala Arg Ala Phe Pro Asn Gly Thr Leu 
                325                 330                 335     


Glu Ile Gly Val Thr Gly Ala Gly Asp Ala Gly Gly Tyr Thr Cys Ile 
            340                 345                 350         


Ala Thr Asn Pro Ala Gly Glu Ala Thr Ala Arg Val Glu Leu Arg Val 
        355                 360                 365             


Leu Ala Leu Pro His Gly Gly Asn Ser Ser Ala Glu Gly Gly Arg Pro 
    370                 375                 380                 


Gly Pro Ser Asp Ile Ala Ala Ser Ala Arg Thr Ala Ala Glu Gly Glu 
385                 390                 395                 400 


Gly Thr Leu Glu Ser Glu Pro Ala Val Gln Val Thr Glu Val Thr Ala 
                405                 410                 415     


Thr Ser Gly Leu Val Ser Trp Gly Pro Gly Arg Pro Ala Asp Pro Val 
            420                 425                 430         


Trp Met Phe Gln Ile Gln Tyr Asn Ser Ser Glu Asp Glu Thr Leu Ile 
        435                 440                 445             


Tyr Arg Ile Val Pro Ala Ser Ser His His Phe Leu Leu Lys His Leu 
    450                 455                 460                 


Val Pro Gly Ala Asp Tyr Asp Leu Cys Leu Leu Ala Leu Ser Pro Ala 
465                 470                 475                 480 


Ala Gly Pro Ser Asp Leu Thr Ala Thr Arg Leu Leu Gly Cys Ala His 
                485                 490                 495     


Phe Ser Thr Leu Pro Ala Ser Pro Leu Cys His Ala Leu Gln Ala His 
            500                 505                 510         


Val Leu Gly Gly Thr Leu Thr Val Ala Val Gly Gly Val Leu Val Ala 
        515                 520                 525             


Ala Leu Leu Val Phe Thr Val Ala Leu Leu Val Arg Gly Arg Gly Ala 
    530                 535                 540                 


Gly Asn Gly Arg Leu Pro Leu Lys Leu Ser His Val Gln Ser Gln Thr 
545                 550                 555                 560 


Asn Gly Gly Pro Ser Pro Thr Pro Lys Ala His Pro Pro Arg Ser Pro 
                565                 570                 575     


Pro Pro Arg Pro Gln Arg Ser Cys Ser Leu Asp Leu Gly Asp Ala Gly 
            580                 585                 590         


Cys Tyr Gly Tyr Ala Arg Arg Leu Gly Gly Ala Trp Ala Arg Arg Ser 
        595                 600                 605             


His Ser Val His Gly Gly Leu Leu Gly Ala Gly Cys Arg Gly Val Gly 
    610                 615                 620                 


Gly Ser Ala Glu Arg Leu Glu Glu Ser Val Val 
625                 630                 635 


<210>  5000
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  5000

Met Glu Glu Lys Tyr Gly Gly Asp Val Leu Ala Gly Pro Gly Gly Gly 
1               5                   10                  15      


Gly Gly Leu Gly Pro Val Asp Val Pro Ser Ala Arg Leu Thr Lys Tyr 
            20                  25                  30          


Ile Val Leu Leu Cys Phe Thr Lys Phe Leu Lys Ala Val Gly Leu Phe 
        35                  40                  45              


Glu Ser Tyr Asp Leu Leu Lys Ala Val His Ile Val Gln Phe Ile Phe 
    50                  55                  60                  


Ile Leu Lys Leu Gly Thr Ala Phe Phe Met Val Leu Phe Gln Lys Pro 
65                  70                  75                  80  


Phe Ser Ser Gly Lys Thr Ile Thr Lys His Gln Ile Ile Gly Ser Leu 
                85                  90                  95      


Lys Ile Pro Gly Arg Lys Glu Phe Lys Asp Lys Lys Leu Asn Asp Pro 
            100                 105                 110         


Arg Lys Leu Val Gly Asn 
        115             


<210>  5001
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  5001

Met Gly Ser Gln His Ser Ala Ala Ala Arg Pro Ser Ser Cys Arg Arg 
1               5                   10                  15      


Lys Gln Glu Asp Asp Arg Asp Gly Leu Leu Ala Glu Arg Glu Gln Glu 
            20                  25                  30          


Glu Ala Ile Ala Gln Phe Pro Tyr Val Glu Phe Thr Gly Arg Asp Ser 
        35                  40                  45              


Ile Thr Cys Leu Thr Cys Gln Gly Thr Gly Tyr Ile Pro Thr Glu Gln 
    50                  55                  60                  


Val Asn Glu Leu Val Ala Leu Ile Pro His Ser Asp Gln Arg Leu Arg 
65                  70                  75                  80  


Pro Gln Arg Thr Lys Gln Tyr Val Leu Leu Ser Ile Leu Leu Cys Leu 
                85                  90                  95      


Leu Ala Ser Gly Leu Val Val Phe Phe Leu Phe Pro His Ser Val Leu 
            100                 105                 110         


Val Asp Asp Asp Gly Ile Lys Val Val Lys Val Thr Phe Asn Lys Gln 
        115                 120                 125             


Asp Ser Leu Val Ile Leu Thr Ile Met Ala Thr Leu Lys Ile Arg Asn 
    130                 135                 140                 


Ser Asn Phe Tyr Thr Val Ala Val Thr Ser Leu Ser Ser Gln Ile Gln 
145                 150                 155                 160 


Tyr Met Asn Thr Val Val Ser Thr Tyr Val Thr Thr Asn Val Ser Leu 
                165                 170                 175     


Ile Pro Pro Arg Ser Glu Gln Leu Val Asn Phe Thr Gly Lys Ala Glu 
            180                 185                 190         


Met Gly Gly Pro Phe Ser Tyr Val Tyr Phe Phe Cys Thr Val Pro Glu 
        195                 200                 205             


Ile Leu Val His Asn Ile Val Ile Phe Met Arg Thr Ser Val Lys Ile 
    210                 215                 220                 


Ser Tyr Ile Gly Leu Met Thr Gln Ser Ser Leu Glu Thr His His Tyr 
225                 230                 235                 240 


Val Asp Cys Gly Gly Asn Ser Thr Ala Ile 
                245                 250 


<210>  5002
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  5002

Met Arg Thr Glu Ala Gln Val Pro Ala Leu Gln Pro Pro Glu Pro Gly 
1               5                   10                  15      


Leu Glu Gly Ala Met Gly His Arg Thr Leu Val Leu Pro Trp Val Leu 
            20                  25                  30          


Leu Thr Leu Cys Val Thr Ala Gly Thr Pro Glu Val Trp Val Gln Val 
        35                  40                  45              


Arg Met Glu Ala Thr Glu Leu Ser Ser Phe Thr Ile Arg Cys Gly Phe 
    50                  55                  60                  


Leu Gly Ser Gly Ser Ile Ser Leu Val Thr Val Ser Trp Gly Gly Pro 
65                  70                  75                  80  


Asn Gly Ala Gly Gly Thr Thr Leu Ala Val Leu His Pro Glu Arg Gly 
                85                  90                  95      


Ile Arg Gln Trp Ala Pro Ala Arg Gln Ala Arg Trp Glu Thr Gln Ser 
            100                 105                 110         


Ser Ile Ser Leu Ile Leu Glu Gly Ser Gly Ala Ser Ser Pro Cys Ala 
        115                 120                 125             


Asn Thr Thr Phe Cys Cys Lys Phe Ala Ser Phe Pro Glu Gly Ser Trp 
    130                 135                 140                 


Glu Ala Cys Gly Ser Leu Pro Pro Ser Ser Asp Pro Gly Leu Ser Ala 
145                 150                 155                 160 


Pro Pro Thr Pro Ala Pro Ile Leu Arg Ala Asp Leu Ala Gly Ile Leu 
                165                 170                 175     


Gly Val Ser Gly Val Leu Leu Phe Gly Cys Val Tyr Leu Leu His Leu 
            180                 185                 190         


Leu Arg Arg His Lys His Arg Pro Ala Pro Arg Leu Gln Pro Ser Arg 
        195                 200                 205             


Thr Ser Pro Gln Ala Pro Arg Ala Arg Ala Trp Ala Pro Ser Gln Ala 
    210                 215                 220                 


Ser Gln Ala Ala Leu His Val Pro Tyr Ala Thr Ile Asn Thr Ser Cys 
225                 230                 235                 240 


Arg Pro Ala Thr Leu Asp Thr Ala His Pro His Gly Gly Pro Ser Trp 
                245                 250                 255     


Trp Ala Ser Leu Pro Thr His Ala Ala His Arg Pro Gln Gly Pro Ala 
            260                 265                 270         


Ala Trp Ala Ser Thr Pro Ile Pro Ala Arg Gly Ser Phe Val Ser Val 
        275                 280                 285             


Glu Asn Gly Leu Tyr Ala Gln Ala Gly Glu Arg Pro Pro His Thr Gly 
    290                 295                 300                 


Pro Gly Leu Thr Leu Phe Pro Asp Pro Arg Gly Pro Arg Ala Met Glu 
305                 310                 315                 320 


Gly Pro Leu Gly Val Arg 
                325     


<210>  5003
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  5003

Met Ala Ala Leu Thr Ile Ala Thr Gly Thr Gly Asn Trp Phe Ser Ala 
1               5                   10                  15      


Leu Ala Leu Gly Val Thr Leu Leu Lys Cys Leu Leu Ile Pro Thr Tyr 
            20                  25                  30          


His Ser Thr Asp Phe Glu Val His Arg Asn Trp Leu Ala Ile Thr His 
        35                  40                  45              


Ser Leu Pro Ile Ser Gln Trp Tyr Tyr Glu Ala Thr Ser Glu Trp Thr 
    50                  55                  60                  


Leu Asp Tyr Pro Pro Phe Phe Ala Trp Phe Glu Tyr Ile Leu Ser His 
65                  70                  75                  80  


Val Ala Lys Tyr Phe Asp Gln Glu Met Leu Asn Val His Asn Leu Asn 
                85                  90                  95      


Tyr Ser Ser Ser Arg Thr Leu Leu Phe Gln Arg Phe Ser Val Ile Phe 
            100                 105                 110         


Met Asp Val Leu Phe Val Tyr Ala Val Arg Glu Cys Cys Lys Cys Ile 
        115                 120                 125             


Asp Gly Lys Lys Val Gly Lys Glu Leu Thr Glu Lys Pro Lys Phe Ile 
    130                 135                 140                 


Leu Ser Val Leu Leu Leu Trp Asn Phe Gly Leu Leu Ile Val Asp His 
145                 150                 155                 160 


Ile His Phe Gln Tyr Asn Gly Phe Leu Phe Gly Leu Met Leu Leu Ser 
                165                 170                 175     


Ile Ala Arg Leu Phe Gln Lys Arg His Met Glu Gly Ala Phe Leu Phe 
            180                 185                 190         


Ala Val Leu Leu His Phe Lys His Ile Tyr Leu Tyr Val Ala Pro Ala 
        195                 200                 205             


Tyr Gly Val Tyr Leu Leu Arg Ser Tyr Cys Phe Thr Ala Asn Lys Pro 
    210                 215                 220                 


Asp Gly Ser Ile Arg Trp Lys Ser Phe Ser Phe Val Arg Val Ile Ser 
225                 230                 235                 240 


Leu Gly Leu Val Val Phe Leu Val Ser Ala Leu Ser Leu Gly Pro Phe 
                245                 250                 255     


Leu Ala Leu Asn Gln Leu Pro Gln Val Phe Ser Arg Leu Phe Pro Phe 
            260                 265                 270         


Lys Arg Gly Leu Cys His Ala Tyr Trp Ala Pro Asn Phe Trp Ala Leu 
        275                 280                 285             


Tyr Asn Ala Leu Asp Lys Val Leu Ser Val Ile Gly Leu Lys Leu Lys 
    290                 295                 300                 


Phe Leu Asp Pro Asn Asn Ile Pro Lys Ala Ser Met Thr Ser Gly Leu 
305                 310                 315                 320 


Val Gln Gln Phe Gln His Thr Val Leu Pro Ser Val Thr Pro Leu Ala 
                325                 330                 335     


Thr Leu Ile Cys Thr Leu Ile Ala Ile Leu Pro Ser Ile Phe Cys Leu 
            340                 345                 350         


Trp Phe Lys Pro Gln Gly Pro Arg Gly Phe Leu Arg Cys Leu Thr Leu 
        355                 360                 365             


Cys Ala Leu Ser Ser Phe Met Phe Gly Trp His Val His Glu Lys Ala 
    370                 375                 380                 


Ile Leu Leu Ala Ile Leu Pro Met Ser Leu Leu Ser Val Gly Lys Ala 
385                 390                 395                 400 


Gly Asp Ala Ser Ile Phe Leu Ile Leu Thr Thr Thr Gly His Tyr Ser 
                405                 410                 415     


Leu Phe Pro Leu Leu Phe Thr Ala Pro Glu Leu Pro Ile Lys Ile Leu 
            420                 425                 430         


Leu Met Leu Leu Phe Thr Ile Tyr Ser Ile Ser Ser Leu Lys Thr Leu 
        435                 440                 445             


Phe Arg Lys Glu Lys Pro Leu Phe Asn Trp Met Glu Thr Phe Tyr Leu 
    450                 455                 460                 


Leu Gly Leu Gly Pro Leu Glu Val Cys Cys Glu Phe Val Phe Pro Phe 
465                 470                 475                 480 


Thr Ser Trp Lys Val Lys Tyr Pro Phe Ile Pro Leu Leu Leu Thr Ser 
                485                 490                 495     


Val Tyr Cys Ala Val Gly Ile Thr Tyr Ala Trp Phe Lys Leu Tyr Val 
            500                 505                 510         


Ser Val Leu Ile Asp Ser Ala Ile Gly Lys Thr Lys Lys Gln 
        515                 520                 525     


<210>  5004
<211>  1104
<212>  PRT
<213>  Homo sapiens

<400>  5004

Met Ser Phe Arg Ala Ala Arg Leu Ser Met Arg Asn Arg Arg Asn Asp 
1               5                   10                  15      


Thr Leu Asp Ser Thr Arg Thr Leu Tyr Ser Ser Ala Ser Arg Ser Thr 
            20                  25                  30          


Asp Leu Ser Tyr Ser Glu Ser Asp Leu Val Asn Phe Ile Gln Ala Asn 
        35                  40                  45              


Phe Lys Lys Arg Glu Cys Val Phe Phe Thr Lys Asp Ser Lys Ala Thr 
    50                  55                  60                  


Glu Asn Val Cys Lys Cys Gly Tyr Ala Gln Ser Gln His Met Glu Gly 
65                  70                  75                  80  


Thr Gln Ile Asn Gln Ser Glu Lys Trp Asn Tyr Lys Lys His Thr Lys 
                85                  90                  95      


Glu Phe Pro Thr Asp Ala Phe Gly Asp Ile Gln Phe Glu Thr Leu Gly 
            100                 105                 110         


Lys Lys Gly Lys Tyr Ile Arg Leu Ser Cys Asp Thr Asp Ala Glu Ile 
        115                 120                 125             


Leu Tyr Glu Leu Leu Thr Gln His Trp His Leu Lys Thr Pro Asn Leu 
    130                 135                 140                 


Val Ile Ser Val Thr Gly Gly Ala Lys Asn Phe Ala Leu Lys Pro Arg 
145                 150                 155                 160 


Met Arg Lys Ile Phe Ser Arg Leu Ile Tyr Ile Ala Gln Ser Lys Gly 
                165                 170                 175     


Ala Trp Ile Leu Thr Gly Gly Thr His Tyr Gly Leu Met Lys Tyr Ile 
            180                 185                 190         


Gly Glu Val Val Arg Asp Asn Thr Ile Ser Arg Ser Ser Glu Glu Asn 
        195                 200                 205             


Ile Val Ala Ile Gly Ile Ala Ala Trp Gly Met Val Ser Asn Arg Asp 
    210                 215                 220                 


Thr Leu Ile Arg Asn Cys Asp Ala Glu Gly Tyr Phe Leu Ala Gln Tyr 
225                 230                 235                 240 


Leu Met Asp Asp Phe Thr Arg Asp Pro Leu Tyr Ile Leu Asp Asn Asn 
                245                 250                 255     


His Thr His Leu Leu Leu Val Asp Asn Gly Cys His Gly His Pro Thr 
            260                 265                 270         


Val Glu Ala Lys Leu Arg Asn Gln Leu Glu Lys Tyr Ile Ser Glu Arg 
        275                 280                 285             


Thr Ile Gln Asp Ser Asn Tyr Gly Gly Lys Ile Pro Ile Val Cys Phe 
    290                 295                 300                 


Ala Gln Gly Gly Gly Lys Glu Thr Leu Lys Ala Ile Asn Thr Ser Ile 
305                 310                 315                 320 


Lys Asn Lys Ile Pro Cys Val Val Val Glu Gly Ser Gly Gln Ile Ala 
                325                 330                 335     


Asp Val Ile Ala Ser Leu Val Glu Val Glu Asp Ala Leu Thr Ser Ser 
            340                 345                 350         


Ala Val Lys Glu Lys Leu Val Arg Phe Leu Pro Arg Thr Val Ser Arg 
        355                 360                 365             


Leu Pro Glu Glu Glu Thr Glu Ser Trp Ile Lys Trp Leu Lys Glu Ile 
    370                 375                 380                 


Leu Glu Cys Ser His Leu Leu Thr Val Ile Lys Met Glu Glu Ala Gly 
385                 390                 395                 400 


Asp Glu Ile Val Ser Asn Ala Ile Ser Tyr Ala Leu Tyr Lys Ala Phe 
                405                 410                 415     


Ser Thr Ser Glu Gln Asp Lys Asp Asn Trp Asn Gly Gln Leu Lys Leu 
            420                 425                 430         


Leu Leu Glu Trp Asn Gln Leu Asp Leu Ala Asn Asp Glu Ile Phe Thr 
        435                 440                 445             


Asn Asp Arg Arg Trp Glu Ser Ala Asp Leu Gln Glu Val Met Phe Thr 
    450                 455                 460                 


Ala Leu Ile Lys Asp Arg Pro Lys Phe Val Arg Leu Phe Leu Glu Asn 
465                 470                 475                 480 


Gly Leu Asn Leu Arg Lys Phe Leu Thr His Asp Val Leu Thr Glu Leu 
                485                 490                 495     


Phe Ser Asn His Phe Ser Thr Leu Val Tyr Arg Asn Leu Gln Ile Ala 
            500                 505                 510         


Lys Asn Ser Tyr Asn Asp Ala Leu Leu Thr Phe Val Trp Lys Leu Val 
        515                 520                 525             


Ala Asn Phe Arg Arg Gly Phe Arg Lys Glu Asp Arg Asn Gly Arg Asp 
    530                 535                 540                 


Glu Met Asp Ile Glu Leu His Asp Val Ser Pro Ile Thr Arg His Pro 
545                 550                 555                 560 


Leu Gln Ala Leu Phe Ile Trp Ala Ile Leu Gln Asn Lys Lys Glu Leu 
                565                 570                 575     


Ser Lys Val Ile Trp Glu Gln Thr Arg Gly Cys Thr Leu Ala Ala Leu 
            580                 585                 590         


Gly Ala Ser Lys Leu Leu Lys Thr Leu Ala Lys Val Lys Asn Asp Ile 
        595                 600                 605             


Asn Ala Ala Gly Glu Ser Glu Glu Leu Ala Asn Glu Tyr Glu Thr Arg 
    610                 615                 620                 


Ala Val Glu Leu Phe Thr Glu Cys Tyr Ser Ser Asp Glu Asp Leu Ala 
625                 630                 635                 640 


Glu Gln Leu Leu Val Tyr Ser Cys Glu Ala Trp Gly Gly Ser Asn Cys 
                645                 650                 655     


Leu Glu Leu Ala Val Glu Ala Thr Asp Gln His Phe Ile Ala Gln Pro 
            660                 665                 670         


Gly Val Gln Asn Phe Leu Ser Lys Gln Trp Tyr Gly Glu Ile Ser Arg 
        675                 680                 685             


Asp Thr Lys Asn Trp Lys Ile Ile Leu Cys Leu Phe Ile Ile Pro Leu 
    690                 695                 700                 


Val Gly Cys Gly Phe Val Ser Phe Arg Lys Lys Pro Val Asp Lys His 
705                 710                 715                 720 


Lys Lys Leu Leu Trp Tyr Tyr Val Ala Phe Phe Thr Ser Pro Phe Val 
                725                 730                 735     


Val Phe Ser Trp Asn Val Val Phe Tyr Ile Ala Phe Leu Leu Leu Phe 
            740                 745                 750         


Ala Tyr Val Leu Leu Met Asp Phe His Ser Val Pro His Pro Pro Glu 
        755                 760                 765             


Leu Val Leu Tyr Ser Leu Val Phe Val Leu Phe Cys Asp Glu Val Arg 
    770                 775                 780                 


Gln Trp Tyr Val Asn Gly Val Asn Tyr Phe Thr Asp Leu Trp Asn Val 
785                 790                 795                 800 


Met Asp Thr Leu Gly Leu Phe Tyr Phe Ile Ala Gly Ile Val Phe Arg 
                805                 810                 815     


Leu His Ser Ser Asn Lys Ser Ser Leu Tyr Ser Gly Arg Val Ile Phe 
            820                 825                 830         


Cys Leu Asp Tyr Ile Ile Phe Thr Leu Arg Leu Ile His Ile Phe Thr 
        835                 840                 845             


Val Ser Arg Asn Leu Gly Pro Lys Ile Ile Met Leu Gln Arg Met Leu 
    850                 855                 860                 


Ile Asp Val Phe Phe Phe Leu Phe Leu Phe Ala Val Trp Met Val Ala 
865                 870                 875                 880 


Phe Gly Val Ala Arg Gln Gly Ile Leu Arg Gln Asn Glu Gln Arg Trp 
                885                 890                 895     


Arg Trp Ile Phe Arg Ser Val Ile Tyr Glu Pro Tyr Leu Ala Met Phe 
            900                 905                 910         


Gly Gln Val Pro Ser Asp Val Asp Gly Thr Thr Tyr Asp Phe Ala His 
        915                 920                 925             


Cys Thr Phe Thr Gly Asn Glu Ser Lys Pro Leu Cys Val Glu Leu Asp 
    930                 935                 940                 


Glu His Asn Leu Pro Arg Phe Pro Glu Trp Ile Thr Ile Pro Leu Val 
945                 950                 955                 960 


Cys Ile Tyr Met Leu Ser Thr Asn Ile Leu Leu Val Asn Leu Leu Val 
                965                 970                 975     


Ala Met Phe Gly Tyr Thr Val Gly Thr Val Gln Glu Asn Asn Asp Gln 
            980                 985                 990         


Val Trp Lys Phe Gln Arg Tyr Phe  Leu Val Gln Glu Tyr  Cys Ser Arg 
        995                 1000                 1005             


Leu Asn  Ile Pro Phe Pro Phe  Ile Val Phe Ala Tyr  Phe Tyr Met 
    1010                 1015                 1020             


Val Val  Lys Lys Cys Phe Lys  Cys Cys Cys Lys Glu  Lys Asn Met 
    1025                 1030                 1035             


Glu Ser  Ser Val Cys Cys Phe  Lys Asn Glu Asp Asn  Glu Thr Leu 
    1040                 1045                 1050             


Ala Trp  Glu Gly Val Met Lys  Glu Asn Tyr Leu Val  Lys Ile Asn 
    1055                 1060                 1065             


Thr Lys  Ala Asn Asp Thr Ser  Glu Glu Met Arg His  Arg Phe Arg 
    1070                 1075                 1080             


Gln Leu  Asp Thr Lys Leu Asn  Asp Leu Lys Gly Leu  Leu Lys Glu 
    1085                 1090                 1095             


Ile Ala  Asn Lys Ile Lys 
    1100                 


<210>  5005
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  5005

Met Phe Thr Leu Leu Val Leu Leu Ser Gln Leu Pro Thr Val Thr Leu 
1               5                   10                  15      


Gly Phe Pro His Cys Ala Arg Gly Pro Lys Ala Ser Lys His Ala Gly 
            20                  25                  30          


Glu Glu Val Phe Thr Ser Lys Glu Glu Ala Asn Phe Phe Ile His Arg 
        35                  40                  45              


Arg Leu Leu Tyr Asn Arg Phe Asp Leu Glu Leu Phe Thr Pro Gly Asn 
    50                  55                  60                  


Leu Glu Arg Glu Cys Asn Glu Glu Leu Cys Asn Tyr Glu Glu Ala Arg 
65                  70                  75                  80  


Glu Ile Phe Val Asp Glu Asp Lys Thr Ile Ala Phe Trp Gln Glu Tyr 
                85                  90                  95      


Ser Ala Lys Gly Pro Thr Thr Lys Ser Asp Gly Asn Arg Glu Lys Ile 
            100                 105                 110         


Asp Val Met Gly Leu Leu Thr Gly Leu Ile Ala Ala Gly Val Phe Leu 
        115                 120                 125             


Val Ile Phe Gly Leu Leu Gly Tyr Tyr Leu Cys Ile Thr Lys Cys Asn 
    130                 135                 140                 


Arg Leu Gln His Pro Cys Ser Ser Ala Val Tyr Glu Arg Gly Arg His 
145                 150                 155                 160 


Thr Pro Ser Ile Ile Phe Arg Arg Pro Glu Glu Ala Ala Leu Ser Pro 
                165                 170                 175     


Leu Pro Pro Ser Val Glu Asp Ala Gly Leu Pro Ser Tyr Glu Gln Ala 
            180                 185                 190         


Val Ala Leu Thr Arg Lys His Ser Val Ser Pro Pro Pro Pro Tyr Pro 
        195                 200                 205             


Gly His Thr Lys Gly Phe Arg Val Phe Lys Lys Ser Met Ser Leu Pro 
    210                 215                 220                 


Ser His 
225     


<210>  5006
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  5006

Met Ala Val Phe Leu Glu Ala Lys Asp Ala His Ser Val Leu Lys Arg 
1               5                   10                  15      


Phe Pro Arg Ala Asn Glu Phe Leu Glu Glu Leu Arg Gln Gly Thr Ile 
            20                  25                  30          


Glu Arg Glu Cys Met Glu Glu Ile Cys Ser Tyr Glu Glu Val Lys Glu 
        35                  40                  45              


Val Phe Glu Asn Lys Glu Lys Thr Met Glu Phe Trp Lys Gly Tyr Pro 
    50                  55                  60                  


Asn Ala Val Tyr Ser Val Arg Asp Pro Ser Gln Ser Ser Asp Ala Met 
65                  70                  75                  80  


Tyr Val Val Val Pro Leu Leu Gly Val Ala Leu Leu Ile Val Ile Ala 
                85                  90                  95      


Leu Phe Ile Ile Trp Arg Cys Gln Leu Gln Lys Ala Thr Arg His His 
            100                 105                 110         


Pro Ser Tyr Ala Gln Asn Arg Tyr Leu Ala Ser Arg Ala Gly His Thr 
        115                 120                 125             


Leu Pro Arg Val Met Val Tyr Arg Gly Thr Val His Ser Gln Gly Glu 
    130                 135                 140                 


Pro Ser Gly His Arg Glu Ala Ala Asn Ser Pro Gln Val Val Leu Gly 
145                 150                 155                 160 


Pro Ser Arg Gly Gly Arg Thr Thr Val Arg Leu Glu Ser Thr Leu Tyr 
                165                 170                 175     


Leu Pro Glu Leu Ser Leu Ser Arg Leu Ser Ser Thr Thr Pro Pro Pro 
            180                 185                 190         


Ser Tyr Glu Glu Val Thr Ala Pro Gln Glu Ser Ser Ser Glu Glu Ala 
        195                 200                 205             


Ser Val Ser Tyr Ser Asp Pro Pro Pro Lys Tyr Glu Glu Ile Val Ala 
    210                 215                 220                 


Ala Asn Pro Gly Ala Asp Lys 
225                 230     


<210>  5007
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  5007

Met Ala Gln Phe Asp Thr Glu Tyr Gln Arg Leu Glu Ala Ser Tyr Ser 
1               5                   10                  15      


Asp Ser Pro Pro Gly Glu Glu Asp Leu Leu Val His Val Ala Glu Gly 
            20                  25                  30          


Ser Lys Ser Pro Trp His His Ile Glu Asn Leu Asp Leu Phe Phe Ser 
        35                  40                  45              


Arg Val Tyr Asn Leu His Gln Lys Asn Gly Phe Thr Cys Met Leu Ile 
    50                  55                  60                  


Gly Glu Ile Phe Glu Leu Met Gln Phe Leu Phe Val Val Ala Phe Thr 
65                  70                  75                  80  


Thr Phe Leu Val Ser Cys Val Asp Tyr Asp Ile Leu Phe Ala Asn Lys 
                85                  90                  95      


Met Val Asn His Ser Leu His Pro Thr Glu Pro Val Lys Val Thr Leu 
            100                 105                 110         


Pro Asp Ala Phe Leu Pro Ala Gln Val Cys Ser Ala Arg Ile Gln Glu 
        115                 120                 125             


Asn Gly Ser Leu Ile Thr Ile Leu Val Ile Ala Gly Val Phe Trp Ile 
    130                 135                 140                 


His Arg Leu Ile Lys Phe Ile Tyr Asn Ile Cys Cys Tyr Trp Glu Ile 
145                 150                 155                 160 


His Ser Phe Tyr Leu His Ala Leu Arg Ile Pro Met Ser Ala Leu Pro 
                165                 170                 175     


Tyr Cys Thr Trp Gln Glu Val Gln Ala Arg Ile Val Gln Thr Gln Lys 
            180                 185                 190         


Glu His Gln Ile Cys Ile His Lys Arg Glu Leu Thr Glu Leu Asp Ile 
        195                 200                 205             


Tyr His Arg Ile Leu Arg Phe Gln Asn Tyr Met Val Ala Leu Val Asn 
    210                 215                 220                 


Lys Ser Leu Leu Pro Leu Arg Phe Arg Leu Pro Gly Leu Gly Glu Ala 
225                 230                 235                 240 


Val Phe Phe Thr Arg Gly Leu Lys Tyr Asn Phe Glu Leu Ile Leu Phe 
                245                 250                 255     


Trp Gly Pro Gly Ser Leu Phe Leu Asn Glu Trp Ser Leu Lys Ala Glu 
            260                 265                 270         


Tyr Lys Arg Gly Gly Gln Arg Leu Glu Leu Ala Gln Arg Leu Ser Asn 
        275                 280                 285             


Arg Ile Leu Trp Ile Gly Ile Ala Asn Phe Leu Leu Cys Pro Leu Ile 
    290                 295                 300                 


Leu Ile Trp Gln Ile Leu Tyr Ala Phe Phe Ser Tyr Ala Glu Val Leu 
305                 310                 315                 320 


Lys Arg Glu Pro Gly Ala Leu Gly Ala Arg Cys Trp Ser Leu Tyr Gly 
                325                 330                 335     


Arg Cys Tyr Leu Arg His Phe Asn Glu Leu Glu His Glu Leu Gln Ser 
            340                 345                 350         


Arg Leu Asn Arg Gly Tyr Lys Pro Ala Ser Lys Tyr Met Asn Cys Phe 
        355                 360                 365             


Leu Ser Pro Leu Leu Thr Leu Leu Ala Lys Asn Gly Ala Phe Phe Ala 
    370                 375                 380                 


Gly Ser Ile Leu Ala Val Leu Ile Ala Leu Thr Ile Tyr Asp Glu Asp 
385                 390                 395                 400 


Val Leu Ala Val Glu His Val Leu Thr Thr Val Thr Leu Leu Gly Val 
                405                 410                 415     


Thr Val Thr Val Cys Arg Ser Phe Ile Pro Asp Gln His Met Val Phe 
            420                 425                 430         


Cys Pro Glu Gln Leu Leu Arg Val Ile Leu Ala His Ile His Tyr Met 
        435                 440                 445             


Pro Asp His Trp Gln Gly Asn Ala His Arg Ser Gln Thr Arg Asp Glu 
    450                 455                 460                 


Phe Ala Gln Leu Phe Gln Tyr Lys Ala Val Phe Ile Leu Glu Glu Leu 
465                 470                 475                 480 


Leu Ser Pro Ile Val Thr Pro Leu Ile Leu Ile Phe Cys Leu Arg Pro 
                485                 490                 495     


Arg Ala Leu Glu Ile Ile Asp Phe Phe Arg Asn Phe Thr Val Glu Val 
            500                 505                 510         


Val Gly Val Gly Asp Thr Cys Ser Phe Ala Gln Met Asp Val Arg Gln 
        515                 520                 525             


His Gly His Pro Gln Trp Leu Ser Ala Gly Gln Thr Glu Ala Ser Val 
    530                 535                 540                 


Tyr Gln Gln Ala Glu Asp Gly Lys Thr Glu Leu Ser Leu Met His Phe 
545                 550                 555                 560 


Ala Ile Thr Asn Pro Gly Trp Gln Pro Pro Arg Glu Ser Thr Ala Phe 
                565                 570                 575     


Leu Gly Phe Leu Lys Glu Gln Val Gln Arg Asp Gly Ala Ala Ala Ser 
            580                 585                 590         


Leu Ala Gln Gly Gly Leu Leu Pro Glu Asn Ala Leu Phe Thr Ser Ile 
        595                 600                 605             


Gln Ser Leu Gln Ser Glu Ser Glu Pro Leu Ser Leu Ile Ala Asn Val 
    610                 615                 620                 


Val Ala Gly Ser Ser Cys Arg Gly Pro Pro Leu Pro Arg Asp Leu Gln 
625                 630                 635                 640 


Gly Ser Arg His Arg Ala Glu Val Ala Ser Ala Leu Arg Ser Phe Ser 
                645                 650                 655     


Pro Leu Gln Pro Gly Gln Ala Pro Thr Gly Arg Ala His Ser Thr Met 
            660                 665                 670         


Thr Gly Ser Gly Val Asp Ala Arg Thr Ala Ser Ser Gly Ser Ser Val 
        675                 680                 685             


Trp Glu Gly Gln Leu Gln Ser Leu Val Leu Ser Glu Tyr Ala Ser Thr 
    690                 695                 700                 


Glu Met Ser Leu His Ala Leu Tyr Met His Gln Leu His Lys Gln Gln 
705                 710                 715                 720 


Ala Gln Ala Glu Pro Glu Arg His Val Trp His Arg Arg Glu Ser Asp 
                725                 730                 735     


Glu Ser Gly Glu Ser Ala Pro Asp Glu Gly Gly Glu Gly Ala Arg Ala 
            740                 745                 750         


Pro Gln Ser Ile Pro Arg Ser Ala Ser Tyr Pro Cys Ala Ala Pro Arg 
        755                 760                 765             


Pro Gly Ala Pro Glu Thr Thr Ala Leu His Gly Gly Phe Gln Arg Arg 
    770                 775                 780                 


Tyr Gly Gly Ile Thr Asp Pro Gly Thr Val Pro Arg Val Pro Ser His 
785                 790                 795                 800 


Phe Ser Arg Leu Pro Leu Gly Gly Trp Ala Glu Asp Gly Gln Ser Ala 
                805                 810                 815     


Ser Arg His Pro Glu Pro Val Pro Glu Glu Gly Ser Glu Asp Glu Leu 
            820                 825                 830         


Pro Pro Gln Val His Lys Val 
        835                 


<210>  5008
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  5008

Met Asn Met Ser Val Leu Thr Leu Gln Glu Tyr Glu Phe Glu Lys Gln 
1               5                   10                  15      


Phe Asn Glu Asn Glu Ala Ile Gln Trp Met Gln Glu Asn Trp Lys Lys 
            20                  25                  30          


Ser Phe Leu Phe Ser Ala Leu Tyr Ala Ala Phe Ile Phe Gly Gly Arg 
        35                  40                  45              


His Leu Met Asn Lys Arg Ala Lys Phe Glu Leu Arg Lys Pro Leu Val 
    50                  55                  60                  


Leu Trp Ser Leu Thr Leu Ala Val Phe Ser Ile Phe Gly Ala Leu Arg 
65                  70                  75                  80  


Thr Gly Ala Tyr Met Val Tyr Ile Leu Met Thr Lys Gly Leu Lys Gln 
                85                  90                  95      


Ser Val Cys Asp Gln Gly Phe Tyr Asn Gly Pro Val Ser Lys Phe Trp 
            100                 105                 110         


Ala Tyr Ala Phe Val Leu Ser Lys Ala Pro Glu Leu Gly Asp Thr Ile 
        115                 120                 125             


Phe Ile Ile Leu Arg Lys Gln Lys Leu Ile Phe Leu His Trp Tyr His 
    130                 135                 140                 


His Ile Thr Val Leu Leu Tyr Ser Trp Tyr Ser Tyr Lys Asp Met Val 
145                 150                 155                 160 


Ala Gly Gly Gly Trp Phe Met Thr Met Asn Tyr Gly Val His Ala Val 
                165                 170                 175     


Met Tyr Ser Tyr Tyr Ala Leu Arg Ala Ala Gly Phe Arg Val Ser Arg 
            180                 185                 190         


Lys Phe Ala Met Phe Ile Thr Leu Ser Gln Ile Thr Gln Met Leu Met 
        195                 200                 205             


Gly Cys Val Val Asn Tyr Leu Val Phe Cys Trp Met Gln His Asp Gln 
    210                 215                 220                 


Cys His Ser His Phe Gln Asn Ile Phe Trp Ser Ser Leu Met Tyr Leu 
225                 230                 235                 240 


Ser Tyr Leu Val Leu Phe Cys His Phe Phe Phe Glu Ala Tyr Ile Gly 
                245                 250                 255     


Lys Met Arg Lys Thr Thr Lys Ala Glu 
            260                 265 


<210>  5009
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  5009

Met Ala Ala Ser Ser Ile Ser Ser Pro Trp Gly Lys His Val Phe Lys 
1               5                   10                  15      


Ala Ile Leu Met Val Leu Val Ala Leu Ile Leu Leu His Ser Ala Leu 
            20                  25                  30          


Ala Gln Ser Arg Arg Asp Phe Ala Pro Pro Gly Gln Gln Lys Arg Glu 
        35                  40                  45              


Ala Pro Val Asp Val Leu Thr Gln Ile Gly Arg Ser Val Arg Gly Thr 
    50                  55                  60                  


Leu Asp Ala Trp Ile Gly Pro Glu Thr Met His Leu Val Ser Glu Ser 
65                  70                  75                  80  


Ser Ser Gln Val Leu Trp Ala Ile Ser Ser Ala Ile Ser Val Ala Phe 
                85                  90                  95      


Phe Ala Leu Ser Gly Ile Ala Ala Gln Leu Leu Asn Ala Leu Gly Leu 
            100                 105                 110         


Ala Gly Asp Tyr Leu Ala Gln Gly Leu Lys Leu Ser Pro Gly Gln Val 
        115                 120                 125             


Gln Thr Phe Leu Leu Trp Gly Ala Gly Ala Leu Val Val Tyr Trp Leu 
    130                 135                 140                 


Leu Ser Leu Leu Leu Gly Leu Val Leu Ala Leu Leu Gly Arg Ile Leu 
145                 150                 155                 160 


Trp Gly Leu Lys Leu Val Ile Phe Leu Ala Gly Phe Val Ala Leu Met 
                165                 170                 175     


Arg Ser Val Pro Asp Pro Ser Thr Arg Ala Leu Leu Leu Leu Ala Leu 
            180                 185                 190         


Leu Ile Leu Tyr Ala Leu Leu Ser Arg Leu Thr Gly Ser Arg Ala Ser 
        195                 200                 205             


Gly Ala Gln Leu Glu Ala Lys Val Arg Gly Leu Glu Arg Gln Val Glu 
    210                 215                 220                 


Glu Leu Arg Trp Arg Gln Arg Arg Ala Ala Lys Gly Ala Arg Ser Val 
225                 230                 235                 240 


Glu Glu Glu 
            


<210>  5010
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  5010

Met Arg Gly Ser Pro Gly Asp Ala Glu Arg Arg Gln Arg Trp Gly Arg 
1               5                   10                  15      


Leu Phe Glu Glu Leu Asp Ser Asn Lys Asp Gly Arg Val Asp Val His 
            20                  25                  30          


Glu Leu Arg Gln Gly Leu Ala Arg Leu Gly Gly Gly Asn Pro Asp Pro 
        35                  40                  45              


Gly Ala Gln Gln Gly Ile Ser Ser Glu Gly Asp Ala Asp Pro Asp Gly 
    50                  55                  60                  


Gly Leu Asp Leu Glu Glu Phe Ser Arg Tyr Leu Gln Glu Arg Glu Gln 
65                  70                  75                  80  


Arg Leu Leu Leu Met Phe His Ser Leu Asp Arg Asn Gln Asp Gly His 
                85                  90                  95      


Ile Asp Val Ser Glu Ile Gln Gln Ser Phe Arg Ala Leu Gly Ile Ser 
            100                 105                 110         


Ile Ser Leu Glu Gln Ala Glu Lys Ile Leu His Ser Met Asp Arg Asp 
        115                 120                 125             


Gly Thr Met Thr Ile Asp Trp Gln Glu Trp Arg Asp His Phe Leu Leu 
    130                 135                 140                 


His Ser Leu Glu Asn Val Glu Asp Val Leu Tyr Phe Trp Lys His Ser 
145                 150                 155                 160 


Thr Val Leu Asp Ile Gly Glu Cys Leu Thr Val Pro Asp Glu Phe Ser 
                165                 170                 175     


Lys Gln Glu Lys Leu Thr Gly Met Trp Trp Lys Gln Leu Val Ala Gly 
            180                 185                 190         


Ala Val Ala Gly Ala Val Ser Arg Thr Gly Thr Ala Pro Leu Asp Arg 
        195                 200                 205             


Leu Lys Val Phe Met Gln Val His Ala Ser Lys Thr Asn Arg Leu Asn 
    210                 215                 220                 


Ile Leu Gly Gly Leu Arg Ser Met Val Leu Glu Gly Gly Ile Arg Ser 
225                 230                 235                 240 


Leu Trp Arg Gly Asn Gly Ile Asn Val Leu Lys Ile Ala Pro Glu Ser 
                245                 250                 255     


Ala Ile Lys Phe Met Ala Tyr Glu Gln Ile Lys Arg Ala Ile Leu Gly 
            260                 265                 270         


Gln Gln Glu Thr Leu His Val Gln Glu Arg Phe Val Ala Gly Ser Leu 
        275                 280                 285             


Ala Gly Ala Thr Ala Gln Thr Ile Ile Tyr Pro Met Glu Val Leu Lys 
    290                 295                 300                 


Thr Arg Leu Thr Leu Arg Arg Thr Gly Gln Tyr Lys Gly Leu Leu Asp 
305                 310                 315                 320 


Cys Ala Arg Arg Ile Leu Glu Arg Glu Gly Pro Arg Ala Phe Tyr Arg 
                325                 330                 335     


Gly Tyr Leu Pro Asn Val Leu Gly Ile Ile Pro Tyr Ala Gly Ile Asp 
            340                 345                 350         


Leu Ala Val Tyr Glu Thr Leu Lys Asn Trp Trp Leu Gln Gln Tyr Ser 
        355                 360                 365             


His Asp Ser Ala Asp Pro Gly Ile Leu Val Leu Leu Ala Cys Gly Thr 
    370                 375                 380                 


Ile Ser Ser Thr Cys Gly Gln Ile Ala Ser Tyr Pro Leu Ala Leu Val 
385                 390                 395                 400 


Arg Thr Arg Met Gln Ala Gln Ala Ser Ile Glu Gly Gly Pro Gln Leu 
                405                 410                 415     


Ser Met Leu Gly Leu Leu Arg His Ile Leu Ser Gln Glu Gly Met Arg 
            420                 425                 430         


Gly Leu Tyr Arg Gly Ile Ala Pro Asn Phe Met Lys Val Ile Pro Ala 
        435                 440                 445             


Val Ser Ile Ser Tyr Val Val Tyr Glu Asn Met Lys Gln Ala Leu Gly 
    450                 455                 460                 


Val Thr Ser Arg 
465             


<210>  5011
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  5011

Met Ile Gly Asp Ile Leu Leu Phe Gly Thr Leu Leu Met Asn Ala Gly 
1               5                   10                  15      


Ala Val Leu Asn Phe Lys Leu Lys Lys Lys Asp Thr Gln Gly Phe Gly 
            20                  25                  30          


Glu Glu Ser Arg Glu Pro Ser Thr Gly Asp Asn Ile Arg Glu Phe Leu 
        35                  40                  45              


Leu Ser Leu Arg Tyr Phe Arg Ile Phe Ile Ala Leu Trp Asn Ile Phe 
    50                  55                  60                  


Met Met Phe Cys Met Ile Val Leu Phe Gly Ser 
65                  70                  75  


<210>  5012
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  5012

Met Ala Gly Lys Gly Ser Ser Gly Arg Arg Pro Leu Leu Leu Gly Leu 
1               5                   10                  15      


Leu Val Ala Val Ala Thr Val His Leu Val Ile Cys Pro Tyr Thr Lys 
            20                  25                  30          


Val Glu Glu Ser Phe Asn Leu Gln Ala Thr His Asp Leu Leu Tyr His 
        35                  40                  45              


Trp Gln Asp Leu Glu Gln Tyr Asp His Leu Glu Phe Pro Gly Val Val 
    50                  55                  60                  


Pro Arg Thr Phe Leu Gly Pro Val Val Ile Ala Val Phe Ser Ser Pro 
65                  70                  75                  80  


Ala Val Tyr Val Leu Ser Leu Leu Glu Met Ser Lys Phe Tyr Ser Gln 
                85                  90                  95      


Leu Ile Val Arg Gly Val Leu Gly Leu Gly Val Ile Phe Gly Leu Trp 
            100                 105                 110         


Thr Leu Gln Lys Glu Val Arg Arg His Phe Gly Ala Met Val Ala Thr 
        115                 120                 125             


Met Phe Cys Trp Val Thr Ala Met Gln Phe His Leu Met Phe Tyr Cys 
    130                 135                 140                 


Thr Arg Thr Leu Pro Asn Val Leu Ala Leu Pro Val Val Leu Leu Ala 
145                 150                 155                 160 


Leu Ala Ala Trp Leu Arg His Glu Trp Ala Arg Phe Ile Trp Leu Ser 
                165                 170                 175     


Ala Phe Ala Ile Ile Val Phe Arg Val Glu Leu Cys Leu Phe Leu Gly 
            180                 185                 190         


Leu Leu Leu Leu Leu Ala Leu Gly Asn Arg Lys Val Ser Val Val Arg 
        195                 200                 205             


Ala Leu Arg His Ala Val Pro Ala Gly Ile Leu Cys Leu Gly Leu Thr 
    210                 215                 220                 


Val Ala Val Asp Ser Tyr Phe Trp Arg Gln Leu Thr Trp Pro Glu Gly 
225                 230                 235                 240 


Lys Val Leu Trp Tyr Asn Thr Val Leu Asn Lys Ser Ser Asn Trp Gly 
                245                 250                 255     


Thr Ser Pro Leu Leu Trp Tyr Phe Tyr Ser Ala Leu Pro Arg Gly Leu 
            260                 265                 270         


Gly Cys Ser Leu Leu Phe Ile Pro Leu Gly Leu Val Asp Arg Arg Thr 
        275                 280                 285             


His Ala Pro Thr Val Leu Ala Leu Gly Phe Met Ala Leu Tyr Ser Leu 
    290                 295                 300                 


Leu Pro His Lys Glu Leu Arg Phe Ile Ile Tyr Ala Phe Pro Met Leu 
305                 310                 315                 320 


Asn Ile Thr Ala Ala Arg Gly Cys Ser Tyr Leu Leu Asn Asn Tyr Lys 
                325                 330                 335     


Lys Ser Trp Leu Tyr Lys Ala Gly Ser Leu Leu Val Ile Gly His Leu 
            340                 345                 350         


Val Val Asn Ala Ala Tyr Ser Ala Thr Ala Leu Tyr Val Ser His Phe 
        355                 360                 365             


Asn Tyr Pro Gly Gly Val Ala Met Gln Arg Leu His Gln Leu Val Pro 
    370                 375                 380                 


Pro Gln Thr Asp Val Leu Leu His Ile Asp Val Ala Ala Ala Gln Thr 
385                 390                 395                 400 


Gly Val Ser Arg Phe Leu Gln Val Asn Ser Ala Trp Arg Tyr Asp Lys 
                405                 410                 415     


Arg Glu Asp Val Gln Pro Gly Thr Gly Met Leu Ala Tyr Thr His Ile 
            420                 425                 430         


Leu Met Glu Ala Ala Pro Gly Leu Leu Ala Leu Tyr Arg Asp Thr His 
        435                 440                 445             


Arg Val Leu Ala Ser Val Val Gly Thr Thr Gly Val Ser Leu Asn Leu 
    450                 455                 460                 


Thr Gln Leu Pro Pro Phe Asn Val His Leu Gln Thr Lys Leu Val Leu 
465                 470                 475                 480 


Leu Glu Arg Leu Pro Arg Pro Ser 
                485             


<210>  5013
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  5013

Met Glu Leu Ser Asp Val Thr Leu Ile Glu Gly Val Gly Asn Glu Val 
1               5                   10                  15      


Met Val Val Ala Gly Val Val Val Leu Ile Leu Ala Leu Val Leu Ala 
            20                  25                  30          


Trp Leu Ser Thr Tyr Val Ala Asp Ser Gly Ser Asn Gln Leu Leu Gly 
        35                  40                  45              


Ala Ile Val Ser Ala Gly Asp Thr Ser Val Leu His Leu Gly His Val 
    50                  55                  60                  


Asp His Leu Val Ala Gly Gln Gly Asn Pro Glu Pro Thr Glu Leu Pro 
65                  70                  75                  80  


His Pro Ser Glu Gly Asn Asp Glu Lys Ala Glu Glu Ala Gly Glu Gly 
                85                  90                  95      


Arg Gly Asp Ser Thr Gly Glu Ala Gly Ala Gly Gly Gly Val Glu Pro 
            100                 105                 110         


Ser Leu Glu His Leu Leu Asp Ile Gln Gly Leu Pro Lys Arg Gln Ala 
        115                 120                 125             


Gly Ala Gly Ser Ser Ser Pro Glu Ala Pro Leu Arg Ser Glu Asp Ser 
    130                 135                 140                 


Thr Cys Leu Pro Pro Ser Pro Gly Leu Ile Thr Val Arg Leu Lys Phe 
145                 150                 155                 160 


Leu Asn Asp Thr Glu Glu Leu Ala Val Ala Arg Pro Glu Asp Thr Val 
                165                 170                 175     


Gly Ala Leu Lys Ser Lys Tyr Phe Pro Gly Gln Glu Ser Gln Met Lys 
            180                 185                 190         


Leu Ile Tyr Gln Gly Arg Leu Leu Gln Asp Pro Ala Arg Thr Leu Arg 
        195                 200                 205             


Ser Leu Asn Ile Thr Asp Asn Cys Val Ile His Cys His Arg Ser Pro 
    210                 215                 220                 


Pro Gly Ser Ala Val Pro Gly Pro Ser Ala Ser Leu Ala Pro Ser Ala 
225                 230                 235                 240 


Thr Glu Pro Pro Ser Leu Gly Val Asn Val Gly Ser Leu Met Val Pro 
                245                 250                 255     


Val Phe Val Val Leu Leu Gly Val Val Trp Tyr Phe Arg Ile Asn Tyr 
            260                 265                 270         


Arg Gln Phe Phe Thr Ala Pro Ala Thr Val Ser Leu Val Gly Val Thr 
        275                 280                 285             


Val Phe Phe Ser Phe Leu Val Phe Gly Met Tyr Gly Arg 
    290                 295                 300     


<210>  5014
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  5014

Met Phe Lys Val Ile Gln Arg Ser Val Gly Pro Ala Ser Leu Ser Leu 
1               5                   10                  15      


Leu Thr Phe Lys Val Tyr Ala Ala Pro Lys Lys Asp Ser Pro Pro Lys 
            20                  25                  30          


Asn Ser Val Lys Val Asp Glu Leu Ser Leu Tyr Ser Val Pro Glu Gly 
        35                  40                  45              


Gln Ser Lys Tyr Val Glu Glu Ala Arg Ser Gln Leu Glu Glu Ser Ile 
    50                  55                  60                  


Ser Gln Leu Arg His Tyr Cys Glu Pro Tyr Thr Thr Trp Cys Gln Glu 
65                  70                  75                  80  


Thr Tyr Ser Gln Thr Lys Pro Lys Met Gln Ser Leu Val Gln Trp Gly 
                85                  90                  95      


Leu Asp Ser Tyr Asp Tyr Leu Gln Asn Ala Pro Pro Gly Phe Phe Pro 
            100                 105                 110         


Arg Leu Gly Val Ile Gly Phe Ala Gly Leu Ile Gly Leu Leu Leu Ala 
        115                 120                 125             


Arg Gly Ser Lys Ile Lys Lys Leu Val Tyr Pro Pro Gly Phe Met Gly 
    130                 135                 140                 


Leu Ala Ala Ser Leu Tyr Tyr Pro Gln Gln Ala Ile Val Phe Ala Gln 
145                 150                 155                 160 


Val Ser Gly Glu Arg Leu Tyr Asp Trp Gly Leu Arg Gly Tyr Ile Val 
                165                 170                 175     


Ile Glu Asp Leu Trp Lys Glu Asn Phe Gln Lys Pro Gly Asn Val Lys 
            180                 185                 190         


Asn Ser Pro Gly Thr Lys 
        195             


<210>  5015
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  5015

Met Ala Ser Gly Gly Gly Gly Gly Asn Thr Gly Ala Gly Gly Gly Pro 
1               5                   10                  15      


Gly Met Gly Leu Ser Leu Gly Leu Gly Leu Gly Leu Ser Leu Gly Met 
            20                  25                  30          


Ser Glu Ala Thr Ser Glu Ala Glu Glu Glu Ala Ala Thr Ala Glu Ala 
        35                  40                  45              


Val Gly Arg Leu Ala Thr Thr Leu Trp Leu Arg Leu Arg Gly Trp Glu 
    50                  55                  60                  


Ala Val Leu Ala Ala Ala Gln Arg Leu Leu Val Trp Glu Lys Pro Leu 
65                  70                  75                  80  


His Ser Leu Val Thr Ala Ala Ala Leu Asn Gly Leu Phe Trp Leu Leu 
                85                  90                  95      


Ser Ser Ser Ser Leu Arg Pro Phe Phe Leu Leu Ser Val Ser Leu Leu 
            100                 105                 110         


Ala Tyr Phe Leu Leu Asp Leu Trp Gln Pro Arg Phe Leu Pro Asp Val 
        115                 120                 125             


Ser Ala Ser Ser Pro Glu Glu Pro His Ser Asp Ser Glu Gly Ala Gly 
    130                 135                 140                 


Ser Gly Ala Arg Pro His Leu Leu Ser Val Pro Glu Leu Cys Arg Tyr 
145                 150                 155                 160 


Leu Ala Glu Ser Trp Leu Thr Phe Gln Ile His Leu Gln Glu Leu Leu 
                165                 170                 175     


Gln Tyr Lys Arg Gln Asn Pro Ala Gln Phe Cys Val Arg Val Cys Ser 
            180                 185                 190         


Gly Cys Ala Val Leu Ala Val Leu Gly His Tyr Val Pro Gly Ile Met 
        195                 200                 205             


Ile Ser Tyr Ile Val Leu Leu Ser Ile Leu Leu Trp Pro Leu Val Val 
    210                 215                 220                 


Tyr His Glu Leu Ile Gln Arg Met Tyr Thr Arg Leu Glu Pro Leu Leu 
225                 230                 235                 240 


Met Gln Leu Asp Tyr Ser Met Lys Ala Glu Ala Asn Ala Leu His His 
                245                 250                 255     


Lys His Asp Lys Arg Lys Arg Gln Gly Lys Asn Ala Pro Pro Gly Gly 
            260                 265                 270         


Asp Glu Pro Leu Ala Glu Thr Glu Ser Glu Ser Glu Ala Glu Leu Ala 
        275                 280                 285             


Gly Phe Ser Pro Val Val Asp Val Lys Lys Thr Ala Leu Ala Leu Ala 
    290                 295                 300                 


Ile Thr Asp Ser Glu Leu Ser Asp Glu Glu Ala Ser Ile Leu Glu Ser 
305                 310                 315                 320 


Gly Gly Phe Ser Val Ser Arg Ala Thr Thr Pro Gln Leu Thr Asp Val 
                325                 330                 335     


Ser Glu Asp Leu Asp Gln Gln Ser Leu Pro Ser Glu Pro Glu Glu Thr 
            340                 345                 350         


Leu Ser Arg Asp Leu Gly Glu Gly Glu Glu Gly Glu Leu Ala Pro Pro 
        355                 360                 365             


Glu Asp Leu Leu Gly Arg Pro Gln Ala Leu Ser Arg Gln Ala Leu Asp 
    370                 375                 380                 


Ser Glu Glu Glu Glu Glu Asp Val Ala Ala Lys Glu Thr Leu Leu Arg 
385                 390                 395                 400 


Leu Ser Ser Pro Leu His Phe Val Asn Thr His Phe Asn Gly Ala Gly 
                405                 410                 415     


Ser Pro Pro Asp Gly Val Lys Cys Ser Pro Gly Gly Pro Val Glu Thr 
            420                 425                 430         


Leu Ser Pro Glu Thr Val Ser Gly Gly Leu Thr Ala Leu Pro Gly Thr 
        435                 440                 445             


Leu Ser Pro Pro Leu Cys Leu Val Gly Ser Asp Pro Ala Pro Ser Pro 
    450                 455                 460                 


Ser Ile Leu Pro Pro Val Pro Gln Asp Ser Pro Gln Pro Leu Pro Ala 
465                 470                 475                 480 


Pro Glu Glu Glu Glu Ala Leu Thr Thr Glu Asp Phe Glu Leu Leu Asp 
                485                 490                 495     


Gln Gly Glu Leu Glu Gln Leu Asn Ala Glu Leu Gly Leu Glu Pro Glu 
            500                 505                 510         


Thr Pro Pro Lys Pro Pro Asp Ala Pro Pro Leu Gly Pro Asp Ile His 
        515                 520                 525             


Ser Leu Val Gln Ser Asp Gln Glu Ala Gln Ala Val Ala Glu Pro 
    530                 535                 540             


<210>  5016
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  5016

Met Ser Asp Ile Gly Asp Trp Phe Arg Ser Ile Pro Ala Ile Thr Arg 
1               5                   10                  15      


Tyr Trp Phe Ala Ala Thr Val Ala Val Pro Leu Val Gly Lys Leu Gly 
            20                  25                  30          


Leu Ile Ser Pro Ala Tyr Leu Phe Leu Trp Pro Glu Ala Phe Leu Tyr 
        35                  40                  45              


Arg Phe Gln Ile Trp Arg Pro Ile Thr Ala Thr Phe Tyr Phe Pro Val 
    50                  55                  60                  


Gly Pro Gly Thr Gly Phe Leu Tyr Leu Val Asn Leu Tyr Phe Leu Tyr 
65                  70                  75                  80  


Gln Tyr Ser Thr Arg Leu Glu Thr Gly Ala Phe Asp Gly Arg Pro Ala 
                85                  90                  95      


Asp Tyr Leu Phe Met Leu Leu Phe Asn Trp Ile Cys Ile Val Ile Thr 
            100                 105                 110         


Gly Leu Ala Met Asp Met Gln Leu Leu Met Ile Pro Leu Ile Met Ser 
        115                 120                 125             


Val Leu Tyr Val Trp Ala Gln Leu Asn Arg Asp Met Ile Val Ser Phe 
    130                 135                 140                 


Trp Phe Gly Thr Arg Phe Lys Ala Cys Tyr Leu Pro Trp Val Ile Leu 
145                 150                 155                 160 


Gly Phe Asn Tyr Ile Ile Gly Gly Ser Val Ile Asn Glu Leu Ile Gly 
                165                 170                 175     


Asn Leu Val Gly His Leu Tyr Phe Phe Leu Met Phe Arg Tyr Pro Met 
            180                 185                 190         


Asp Leu Gly Gly Arg Asn Phe Leu Ser Thr Pro Gln Phe Leu Tyr Arg 
        195                 200                 205             


Trp Leu Pro Ser Arg Arg Gly Gly Val Ser Gly Phe Gly Val Pro Pro 
    210                 215                 220                 


Ala Ser Met Arg Arg Ala Ala Asp Gln Asn Gly Gly Gly Gly Arg His 
225                 230                 235                 240 


Asn Trp Gly Gln Gly Phe Arg Leu Gly Asp Gln 
                245                 250     


<210>  5017
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  5017

Met Ser Pro Glu Glu Trp Thr Tyr Leu Val Val Leu Leu Ile Ser Ile 
1               5                   10                  15      


Pro Ile Gly Phe Leu Phe Lys Lys Ala Gly Pro Gly Leu Lys Arg Trp 
            20                  25                  30          


Gly Ala Ala Ala Val Gly Leu Gly Leu Thr Leu Phe Thr Cys Gly Pro 
        35                  40                  45              


His Thr Leu His Ser Leu Val Thr Ile Leu Gly Thr Trp Ala Leu Ile 
    50                  55                  60                  


Gln Ala Gln Pro Cys Ser Cys His Ala Leu Ala Leu Ala Trp Thr Phe 
65                  70                  75                  80  


Ser Tyr Leu Leu Phe Phe Arg Ala Leu Ser Leu Leu Gly Leu Pro Thr 
                85                  90                  95      


Pro Thr Pro Phe Thr Asn Ala Val Gln Leu Leu Leu Thr Leu Lys Leu 
            100                 105                 110         


Val Ser Leu Ala Ser Glu Val Gln Asp Leu His Leu Ala Gln Arg Lys 
        115                 120                 125             


Glu Met Ala Ser Gly Phe Ser Lys Gly Pro Thr Leu Gly Leu Leu Pro 
    130                 135                 140                 


Asp Val Pro Ser Leu Met Glu Thr Leu Ser Tyr Ser Tyr Cys Tyr Val 
145                 150                 155                 160 


Gly Ile Met Thr Gly Pro Phe Phe Arg Tyr Arg Thr Tyr Leu Asp Trp 
                165                 170                 175     


Leu Glu Gln Pro Phe Pro Gly Ala Val Pro Ser Leu Arg Pro Leu Leu 
            180                 185                 190         


Arg Arg Ala Trp Pro Ala Pro Leu Phe Gly Leu Leu Phe Leu Leu Ser 
        195                 200                 205             


Ser His Leu Phe Pro Leu Glu Ala Val Arg Glu Asp Ala Phe Tyr Ala 
    210                 215                 220                 


Arg Pro Leu Pro Ala Arg Leu Phe Tyr Met Ile Pro Val Phe Phe Ala 
225                 230                 235                 240 


Phe Arg Met Arg Phe Tyr Val Ala Trp Ile Ala Ala Glu Cys Gly Cys 
                245                 250                 255     


Ile Ala Ala Gly Phe Gly Ala Tyr Pro Val Ala Ala Lys Ala Arg Ala 
            260                 265                 270         


Gly Gly Gly Pro Thr Leu Gln Cys Pro Pro Pro Ser Ser Pro Glu Lys 
        275                 280                 285             


Ala Ala Ser Leu Glu Tyr Asp Tyr Glu Thr Ile Arg Asn Ile Asp Cys 
    290                 295                 300                 


Tyr Ser Thr Asp Phe Cys Val Arg Val Arg Asp Gly Met Arg Tyr Trp 
305                 310                 315                 320 


Asn Met Thr Val Gln Trp Trp Leu Ala Gln Tyr Ile Tyr Lys Ser Ala 
                325                 330                 335     


Pro Ala Arg Ser Tyr Val Leu Arg Ser Ala Trp Thr Met Leu Leu Ser 
            340                 345                 350         


Ala Tyr Trp His Gly Leu His Pro Gly Tyr Tyr Leu Ser Phe Leu Thr 
        355                 360                 365             


Ile Pro Leu Cys Leu Ala Ala Glu Gly Arg Leu Glu Ser Ala Leu Arg 
    370                 375                 380                 


Gly Arg Leu Ser Pro Gly Gly Gln Lys Ala Trp Asp Trp Val His Trp 
385                 390                 395                 400 


Phe Leu Lys Met Arg Ala Tyr Asp Tyr Met Cys Met Gly Phe Val Leu 
                405                 410                 415     


Leu Ser Leu Ala Asp Thr Leu Arg Tyr Trp Ala Ser Ile Tyr Phe Cys 
            420                 425                 430         


Ile His Phe Leu Ala Leu Ala Ala Leu Gly Leu Gly Leu Ala Leu Gly 
        435                 440                 445             


Gly Gly Ser Pro Ser Arg Arg Lys Ala Ala Ser Gln Pro Thr Ser Leu 
    450                 455                 460                 


Ala Pro Glu Lys Leu Arg Glu Glu 
465                 470         


<210>  5018
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  5018

Met Arg Leu Thr Arg Cys Gln Ala Ala Leu Ala Ala Ala Ile Thr Leu 
1               5                   10                  15      


Asn Leu Leu Val Leu Phe Tyr Val Ser Trp Leu Gln His Gln Pro Arg 
            20                  25                  30          


Asn Ser Arg Ala Arg Gly Pro Arg Arg Ala Ser Ala Ala Gly Pro Arg 
        35                  40                  45              


Val Thr Val Leu Val Arg Glu Phe Glu Ala Phe Asp Asn Ala Val Pro 
    50                  55                  60                  


Glu Leu Val Asp Ser Phe Leu Gln Gln Asp Pro Ala Gln Pro Val Val 
65                  70                  75                  80  


Val Ala Ala Asp Thr Leu Pro Tyr Pro Pro Leu Ala Leu Pro Arg Ile 
                85                  90                  95      


Pro Asn Val Arg Leu Ala Leu Leu Gln Pro Ala Leu Asp Arg Pro Ala 
            100                 105                 110         


Ala Ala Ser Arg Pro Glu Thr Tyr Val Ala Thr Glu Phe Val Ala Leu 
        115                 120                 125             


Val Pro Asp Gly Ala Arg Ala Glu Ala Pro Gly Leu Leu Glu Arg Met 
    130                 135                 140                 


Val Glu Ala Leu Arg Ala Gly Ser Ala Arg Leu Val Ala Ala Pro Val 
145                 150                 155                 160 


Ala Thr Ala Asn Pro Ala Arg Cys Leu Ala Leu Asn Val Ser Leu Arg 
                165                 170                 175     


Glu Trp Thr Ala Arg Tyr Gly Ala Ala Pro Ala Ala Pro Arg Cys Asp 
            180                 185                 190         


Ala Leu Asp Gly Asp Ala Val Val Leu Leu Arg Ala Arg Asp Leu Phe 
        195                 200                 205             


Asn Leu Ser Ala Pro Leu Ala Arg Pro Val Gly Thr Ser Leu Phe Leu 
    210                 215                 220                 


Gln Thr Ala Leu Arg Gly Trp Ala Val Gln Leu Leu Asp Leu Thr Phe 
225                 230                 235                 240 


Ala Ala Ala Arg Gln Pro Pro Leu Ala Thr Ala His Ala Arg Trp Lys 
                245                 250                 255     


Ala Glu Arg Glu Gly Arg Ala Arg Arg Ala Ala Leu Leu Arg Ala Leu 
            260                 265                 270         


Gly Ile Arg Leu Val Ser Trp Glu Gly Gly Arg Leu Glu Trp Phe Gly 
        275                 280                 285             


Cys Asn Lys Glu Thr Thr Arg Cys Phe Gly Thr Val Val Gly Asp Thr 
    290                 295                 300                 


Pro Ala Tyr Leu Tyr Glu Glu Arg Trp Thr Pro Pro Cys Cys Leu Arg 
305                 310                 315                 320 


Ala Leu Arg Glu Thr Ala Arg Tyr Val Val Gly Val Leu Glu Ala Ala 
                325                 330                 335     


Gly Val Arg Tyr Trp Leu Glu Gly Gly Ser Leu Leu Gly Ala Ala Arg 
            340                 345                 350         


His Gly Asp Ile Ile Pro Trp Asp Tyr Asp Val Asp Leu Gly Ile Tyr 
        355                 360                 365             


Leu Glu Asp Val Gly Asn Cys Glu Gln Leu Arg Gly Ala Glu Ala Gly 
    370                 375                 380                 


Ser Val Val Asp Glu Arg Gly Phe Val Trp Glu Lys Ala Val Glu Gly 
385                 390                 395                 400 


Asp Phe Phe Arg Val Gln Tyr Ser Glu Ser Asn His Leu His Val Asp 
                405                 410                 415     


Leu Trp Pro Phe Tyr Pro Arg Asn Gly Val Met Thr Lys Asp Thr Trp 
            420                 425                 430         


Leu Asp His Arg Gln Asp Val Glu Phe Pro Glu His Phe Leu Gln Pro 
        435                 440                 445             


Leu Val Pro Leu Pro Phe Ala Gly Phe Val Ala Gln Ala Pro Asn Asn 
    450                 455                 460                 


Tyr Arg Arg Phe Leu Glu Leu Lys Phe Gly Pro Gly Val Ile Glu Asn 
465                 470                 475                 480 


Pro Gln Tyr Pro Asn Pro Ala Leu Leu Ser Leu Thr Gly Ser Gly 
                485                 490                 495 


<210>  5019
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  5019

Met Ala Pro Ala Pro Pro Pro Ala Ala Ser Phe Ser Pro Ser Glu Val 
1               5                   10                  15      


Gln Arg Arg Leu Ala Ala Gly Ala Cys Trp Val Arg Arg Gly Ala Arg 
            20                  25                  30          


Leu Tyr Asp Leu Ser Ser Phe Val Arg His His Pro Gly Gly Glu Gln 
        35                  40                  45              


Leu Leu Arg Ala Arg Ala Gly Gln Asp Ile Ser Ala Asp Leu Asp Gly 
    50                  55                  60                  


Pro Pro His Arg His Ser Ala Asn Ala Arg Arg Trp Leu Glu Gln Tyr 
65                  70                  75                  80  


Tyr Val Gly Glu Leu Arg Gly Glu Gln Gln Gly Ser Met Glu Asn Glu 
                85                  90                  95      


Pro Val Ala Leu Glu Glu Thr Gln Lys Thr Asp Pro Ala Met Glu Pro 
            100                 105                 110         


Arg Phe Lys Val Val Asp Trp Asp Lys Asp Leu Val Asp Trp Arg Lys 
        115                 120                 125             


Pro Leu Leu Trp Gln Val Gly His Leu Gly Glu Lys Tyr Asp Glu Trp 
    130                 135                 140                 


Val His Gln Pro Val Thr Arg Pro Ile Arg Leu Phe His Ser Asp Leu 
145                 150                 155                 160 


Ile Glu Gly Leu Ser Lys Thr Val Trp Tyr Ser Val Pro Ile Ile Trp 
                165                 170                 175     


Val Pro Leu Val Leu Tyr Leu Ser Trp Ser Tyr Tyr Arg Thr Phe Ala 
            180                 185                 190         


Gln Gly Asn Val Arg Leu Phe Thr Ser Phe Thr Thr Glu Tyr Thr Val 
        195                 200                 205             


Ala Val Pro Lys Ser Met Phe Pro Gly Leu Phe Met Leu Gly Thr Phe 
    210                 215                 220                 


Leu Trp Ser Leu Ile Glu Tyr Leu Ile His Arg Phe Leu Phe His Met 
225                 230                 235                 240 


Lys Pro Pro Ser Asp Ser Tyr Tyr Leu Ile Met Leu His Phe Val Met 
                245                 250                 255     


His Gly Gln His His Lys Ala Pro Phe Asp Gly Ser Arg Leu Val Phe 
            260                 265                 270         


Pro Pro Val Pro Ala Ser Leu Val Ile Gly Val Phe Tyr Leu Cys Met 
        275                 280                 285             


Gln Leu Ile Leu Pro Glu Ala Val Gly Gly Thr Val Phe Ala Gly Gly 
    290                 295                 300                 


Leu Leu Gly Tyr Val Leu Tyr Asp Met Thr His Tyr Tyr Leu His Phe 
305                 310                 315                 320 


Gly Ser Pro His Lys Gly Ser Tyr Leu Tyr Ser Leu Lys Ala His His 
                325                 330                 335     


Val Lys His His Phe Ala His Gln Lys Ser Gly Phe Gly Ile Ser Thr 
            340                 345                 350         


Lys Leu Trp Asp Tyr Cys Phe His Thr Leu Thr Pro Glu Lys Pro His 
        355                 360                 365             


Leu Lys Thr Gln 
    370         


<210>  5020
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  5020

Met Ser Leu Leu Leu Tyr Tyr Ala Leu Pro Ala Leu Gly Ser Tyr Ala 
1               5                   10                  15      


Met Leu Ser Ile Phe Phe Leu Arg Arg Pro His Leu Leu His Thr Pro 
            20                  25                  30          


Arg Ala Pro Thr Phe Arg Ile Arg Leu Gly Ala His Arg Gly Gly Ser 
        35                  40                  45              


Gly Glu Leu Leu Glu Asn Thr Met Glu Ala Met Glu Asn Ser Met Ala 
    50                  55                  60                  


Gln Arg Ser Asp Leu Leu Glu Leu Asp Cys Gln Leu Thr Arg Asp Arg 
65                  70                  75                  80  


Val Val Val Val Ser His Asp Glu Asn Leu Cys Arg Gln Ser Gly Leu 
                85                  90                  95      


Asn Arg Asp Val Gly Ser Leu Asp Phe Glu Asp Leu Pro Leu Tyr Lys 
            100                 105                 110         


Glu Lys Leu Glu Val Tyr Phe Ser Pro Gly His Phe Ala His Gly Ser 
        115                 120                 125             


Asp Arg Arg Met Val Arg Leu Glu Asp Leu Phe Gln Arg Phe Pro Arg 
    130                 135                 140                 


Thr Pro Met Ser Val Glu Ile Lys Gly Lys Asn Glu Glu Leu Ile Arg 
145                 150                 155                 160 


Glu Ile Ala Gly Leu Val Arg Arg Tyr Asp Arg Asn Glu Ile Thr Ile 
                165                 170                 175     


Trp Ala Ser Glu Lys Ser Ser Val Met Lys Lys Cys Lys Ala Ala Asn 
            180                 185                 190         


Pro Glu Met Pro Leu Ser Phe Thr Ile Ser Arg Gly Phe Trp Val Leu 
        195                 200                 205             


Leu Ser Tyr Tyr Leu Gly Leu Leu Pro Phe Ile Pro Ile Pro Glu Lys 
    210                 215                 220                 


Phe Phe Phe Cys Phe Leu Pro Asn Ile Ile Asn Arg Thr Tyr Phe Pro 
225                 230                 235                 240 


Phe Ser Cys Ser Cys Leu Asn Gln Leu Leu Ala Val Val Ser Lys Trp 
                245                 250                 255     


Leu Ile Met Arg Lys Ser Leu Ile Arg His Leu Glu Glu Arg Gly Val 
            260                 265                 270         


Gln Val Val Phe Trp Cys Leu Asn Glu Glu Ser Asp Phe Glu Ala Ala 
        275                 280                 285             


Phe Ser Val Gly Ala Thr Gly Val Ile Thr Asp Tyr Pro Thr Ala Leu 
    290                 295                 300                 


Arg His Tyr Leu Asp Asn His Gly Pro Ala Ala Arg Thr Ser 
305                 310                 315             


<210>  5021
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  5021

Met Ala Arg Pro Gly Met Glu Arg Trp Arg Asp Arg Leu Ala Leu Val 
1               5                   10                  15      


Thr Gly Ala Ser Gly Gly Ile Gly Ala Ala Val Ala Arg Ala Leu Val 
            20                  25                  30          


Gln Gln Gly Leu Lys Val Val Gly Cys Ala Arg Thr Val Gly Asn Ile 
        35                  40                  45              


Glu Glu Leu Ala Ala Glu Cys Lys Ser Ala Gly Tyr Pro Gly Thr Leu 
    50                  55                  60                  


Ile Pro Tyr Arg Cys Asp Leu Ser Asn Glu Glu Asp Ile Leu Ser Met 
65                  70                  75                  80  


Phe Ser Ala Ile Arg Ser Gln His Ser Gly Val Asp Ile Cys Ile Asn 
                85                  90                  95      


Asn Ala Gly Leu Ala Arg Pro Asp Thr Leu Leu Ser Gly Ser Thr Ser 
            100                 105                 110         


Gly Trp Lys Asp Met Phe Asn Val Asn Val Leu Ala Leu Ser Ile Cys 
        115                 120                 125             


Thr Arg Glu Ala Tyr Gln Ser Met Lys Glu Arg Asn Val Asp Asp Gly 
    130                 135                 140                 


His Ile Ile Asn Ile Asn Ser Met Ser Gly His Arg Val Leu Pro Leu 
145                 150                 155                 160 


Ser Val Thr His Phe Tyr Ser Ala Thr Lys Tyr Ala Val Thr Ala Leu 
                165                 170                 175     


Thr Glu Gly Leu Arg Gln Glu Leu Arg Glu Ala Gln Thr His Ile Arg 
            180                 185                 190         


Ala Thr Cys Ile Ser Pro Gly Val Val Glu Thr Gln Phe Ala Phe Lys 
        195                 200                 205             


Leu His Asp Lys Asp Pro Glu Lys Ala Ala Ala Thr Tyr Glu Gln Met 
    210                 215                 220                 


Lys Cys Leu Lys Pro Glu Asp Val Ala Glu Ala Val Ile Tyr Val Leu 
225                 230                 235                 240 


Ser Thr Pro Ala His Ile Gln Ile Gly Asp Ile Gln Met Arg Pro Thr 
                245                 250                 255     


Glu Gln Val Thr 
            260 


<210>  5022
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  5022

Met Ser Pro Glu Ser Lys Lys Leu Phe Asn Ile Ile Ile Leu Gly Val 
1               5                   10                  15      


Ala Phe Met Phe Met Phe Thr Ala Phe Gln Thr Cys Gly Asn Val Ala 
            20                  25                  30          


Gln Thr Val Ile Arg Ser Leu Asn Arg Thr Asp Phe His Gly Ser Gly 
        35                  40                  45              


Tyr Thr Ser Met Ala Ile Ile Tyr Gly Val Phe Ser Ala Ser Asn Leu 
    50                  55                  60                  


Ile Thr Pro Ser Val Val Ala Ile Val Gly Pro Gln Leu Ser Met Phe 
65                  70                  75                  80  


Ala Ser Gly Leu Phe Tyr Ser Met Tyr Ile Ala Val Phe Ile Gln Pro 
                85                  90                  95      


Phe Pro Trp Ser Phe Tyr Thr Ala Ser Val Phe Ile Gly Ile Ala Ala 
            100                 105                 110         


Ala Val Leu Trp Thr Ala Gln Gly Asn Cys Leu Thr Ile Asn Ser Asp 
        115                 120                 125             


Glu His Ser Ile Gly Arg Asn Ser Gly Ile Phe Trp Ala Leu Leu Gln 
    130                 135                 140                 


Ser Ser Leu Phe Phe Gly Asn Leu Tyr Ile Tyr Phe Ala Trp Gln Gly 
145                 150                 155                 160 


Lys Thr Gln Ile Ser Glu Ser Asp Arg Arg Thr Val Phe Ile Ala Leu 
                165                 170                 175     


Thr Val Ile Ser Leu Val Gly Thr Val Leu Phe Phe Leu Ile Arg Lys 
            180                 185                 190         


Pro Asp Ser Glu Asn Val Leu Gly Glu Asp Glu Ser Ser Asp Asp Gln 
        195                 200                 205             


Asp Met Glu Val Asn Glu Ser Ala Gln Asn Asn Leu Thr Lys Ala Val 
    210                 215                 220                 


Asp Ala Phe Lys Lys Ser Phe Lys Leu Cys Val Thr Lys Glu Met Leu 
225                 230                 235                 240 


Leu Leu Ser Ile Thr Thr Ala Tyr Thr Gly Leu Glu Leu Thr Phe Phe 
                245                 250                 255     


Ser Gly Val Tyr Gly Thr Cys Ile Gly Ala Thr Asn Lys Phe Gly Ala 
            260                 265                 270         


Glu Glu Lys Ser Leu Ile Gly Leu Ser Gly Ile Phe Ile Gly Ile Gly 
        275                 280                 285             


Glu Ile Leu Gly Gly Ser Leu Phe Gly Leu Leu Ser Lys Asn Asn Arg 
    290                 295                 300                 


Phe Gly Arg Asn Pro Val Val Leu Leu Gly Ile Leu Val His Phe Ile 
305                 310                 315                 320 


Ala Phe Tyr Leu Ile Phe Leu Asn Met Pro Gly Asp Ala Pro Ile Ala 
                325                 330                 335     


Pro Val Lys Gly Thr Asp Ser Ser Ala Tyr Ile Lys Ser Ser Lys Glu 
            340                 345                 350         


Val Ala Ile Leu Cys Ser Phe Leu Leu Gly Leu Gly Asp Ser Cys Phe 
        355                 360                 365             


Asn Thr Gln Leu Leu Ser Ile Leu Gly Phe Leu Tyr Ser Glu Asp Ser 
    370                 375                 380                 


Ala Pro Ala Phe Ala Ile Phe Lys Phe Val Gln Ser Ile Cys Ala Ala 
385                 390                 395                 400 


Val Ala Phe Phe Tyr Ser Asn Tyr Leu Leu Leu His Trp Gln Leu Leu 
                405                 410                 415     


Val Met Val Ile Phe Gly Phe Phe Gly Thr Ile Ser Phe Phe Thr Val 
            420                 425                 430         


Glu Trp Glu Ala Ala Ala Phe Val Ala Arg Gly Ser Asp Tyr Arg Ser 
        435                 440                 445             


Ile 
    


<210>  5023
<211>  1256
<212>  PRT
<213>  Homo sapiens

<400>  5023

Met Leu Phe Lys Leu Leu Gln Arg Gln Thr Tyr Thr Cys Leu Ser His 
1               5                   10                  15      


Arg Tyr Gly Leu Tyr Val Cys Phe Leu Gly Val Val Val Thr Ile Val 
            20                  25                  30          


Ser Ala Phe Gln Phe Gly Glu Val Val Leu Glu Trp Ser Arg Asp Gln 
        35                  40                  45              


Tyr His Val Leu Phe Asp Ser Tyr Arg Asp Asn Ile Ala Gly Lys Ser 
    50                  55                  60                  


Phe Gln Asn Arg Leu Cys Leu Pro Met Pro Ile Asp Val Val Tyr Thr 
65                  70                  75                  80  


Trp Val Asn Gly Thr Asp Leu Glu Leu Leu Lys Glu Leu Gln Gln Val 
                85                  90                  95      


Arg Glu Gln Met Glu Glu Glu Gln Lys Ala Met Arg Glu Ile Leu Gly 
            100                 105                 110         


Lys Asn Thr Thr Glu Pro Thr Lys Lys Ser Glu Lys Gln Leu Glu Cys 
        115                 120                 125             


Leu Leu Thr His Cys Ile Lys Val Pro Met Leu Val Leu Asp Pro Ala 
    130                 135                 140                 


Leu Pro Ala Asn Ile Thr Leu Lys Asp Leu Pro Ser Leu Tyr Pro Ser 
145                 150                 155                 160 


Phe His Ser Ala Ser Asp Ile Phe Asn Val Ala Lys Pro Lys Asn Pro 
                165                 170                 175     


Ser Thr Asn Val Ser Val Val Val Phe Asp Ser Thr Lys Asp Val Glu 
            180                 185                 190         


Asp Ala His Ser Gly Leu Leu Lys Gly Asn Ser Arg Gln Thr Val Trp 
        195                 200                 205             


Arg Gly Tyr Leu Thr Thr Asp Lys Glu Val Pro Gly Leu Val Leu Met 
    210                 215                 220                 


Gln Asp Leu Ala Phe Leu Ser Gly Phe Pro Pro Thr Phe Lys Glu Thr 
225                 230                 235                 240 


Asn Gln Leu Lys Thr Lys Leu Pro Glu Asn Leu Ser Ser Lys Val Lys 
                245                 250                 255     


Leu Leu Gln Leu Tyr Ser Glu Ala Ser Val Ala Leu Leu Lys Leu Asn 
            260                 265                 270         


Asn Pro Lys Asp Phe Gln Glu Leu Asn Lys Gln Thr Lys Lys Asn Met 
        275                 280                 285             


Thr Ile Asp Gly Lys Glu Leu Thr Ile Ser Pro Ala Tyr Leu Leu Trp 
    290                 295                 300                 


Asp Leu Ser Ala Ile Ser Gln Ser Lys Gln Asp Glu Asp Ile Ser Ala 
305                 310                 315                 320 


Ser Arg Phe Glu Asp Asn Glu Glu Leu Arg Tyr Ser Leu Arg Ser Ile 
                325                 330                 335     


Glu Arg His Ala Pro Trp Val Arg Asn Ile Phe Ile Val Thr Asn Gly 
            340                 345                 350         


Gln Ile Pro Ser Trp Leu Asn Leu Asp Asn Pro Arg Val Thr Ile Val 
        355                 360                 365             


Thr His Gln Asp Val Phe Arg Asn Leu Ser His Leu Pro Thr Phe Ser 
    370                 375                 380                 


Ser Pro Ala Ile Glu Ser His Ile His Arg Ile Glu Gly Leu Ser Gln 
385                 390                 395                 400 


Lys Phe Ile Tyr Leu Asn Asp Asp Val Met Phe Gly Lys Asp Val Trp 
                405                 410                 415     


Pro Asp Asp Phe Tyr Ser His Ser Lys Gly Gln Lys Val Tyr Leu Thr 
            420                 425                 430         


Trp Pro Val Pro Asn Cys Ala Glu Gly Cys Pro Gly Ser Trp Ile Lys 
        435                 440                 445             


Asp Gly Tyr Cys Asp Lys Ala Cys Asn Asn Ser Ala Cys Asp Trp Asp 
    450                 455                 460                 


Gly Gly Asp Cys Ser Gly Asn Ser Gly Gly Ser Arg Tyr Ile Ala Gly 
465                 470                 475                 480 


Gly Gly Gly Thr Gly Ser Ile Gly Val Gly Gln Pro Trp Gln Phe Gly 
                485                 490                 495     


Gly Gly Ile Asn Ser Val Ser Tyr Cys Asn Gln Gly Cys Ala Asn Ser 
            500                 505                 510         


Trp Leu Ala Asp Lys Phe Cys Asp Gln Ala Cys Asn Val Leu Ser Cys 
        515                 520                 525             


Gly Phe Asp Ala Gly Asp Cys Gly Gln Asp His Phe His Glu Leu Tyr 
    530                 535                 540                 


Lys Val Ile Leu Leu Pro Asn Gln Thr His Tyr Ile Ile Pro Lys Gly 
545                 550                 555                 560 


Glu Cys Leu Pro Tyr Phe Ser Phe Ala Glu Val Ala Lys Arg Gly Val 
                565                 570                 575     


Glu Gly Ala Tyr Ser Asp Asn Pro Ile Ile Arg His Ala Ser Ile Ala 
            580                 585                 590         


Asn Lys Trp Lys Thr Ile His Leu Ile Met His Ser Gly Met Asn Ala 
        595                 600                 605             


Thr Thr Ile His Phe Asn Leu Thr Phe Gln Asn Thr Asn Asp Glu Glu 
    610                 615                 620                 


Phe Lys Met Gln Ile Thr Val Glu Val Asp Thr Arg Glu Gly Pro Lys 
625                 630                 635                 640 


Leu Asn Ser Thr Ala Gln Lys Gly Tyr Glu Asn Leu Val Ser Pro Ile 
                645                 650                 655     


Thr Leu Leu Pro Glu Ala Glu Ile Leu Phe Glu Asp Ile Pro Lys Glu 
            660                 665                 670         


Lys Arg Phe Pro Lys Phe Lys Arg His Asp Val Asn Ser Thr Arg Arg 
        675                 680                 685             


Ala Gln Glu Glu Val Lys Ile Pro Leu Val Asn Ile Ser Leu Leu Pro 
    690                 695                 700                 


Lys Asp Ala Gln Leu Ser Leu Asn Thr Leu Asp Leu Gln Leu Glu His 
705                 710                 715                 720 


Gly Asp Ile Thr Leu Lys Gly Tyr Asn Leu Ser Lys Ser Ala Leu Leu 
                725                 730                 735     


Arg Ser Phe Leu Met Asn Ser Gln His Ala Lys Ile Lys Asn Gln Ala 
            740                 745                 750         


Ile Ile Thr Asp Glu Thr Asn Asp Ser Leu Val Ala Pro Gln Glu Lys 
        755                 760                 765             


Gln Val His Lys Ser Ile Leu Pro Asn Ser Leu Gly Val Ser Glu Arg 
    770                 775                 780                 


Leu Gln Arg Leu Thr Phe Pro Ala Val Ser Val Lys Val Asn Gly His 
785                 790                 795                 800 


Asp Gln Gly Gln Asn Pro Pro Leu Asp Leu Glu Thr Thr Ala Arg Phe 
                805                 810                 815     


Arg Val Glu Thr His Thr Gln Lys Thr Ile Gly Gly Asn Val Thr Lys 
            820                 825                 830         


Glu Lys Pro Pro Ser Leu Ile Val Pro Leu Glu Ser Gln Met Thr Lys 
        835                 840                 845             


Glu Lys Lys Ile Thr Gly Lys Glu Lys Glu Asn Ser Arg Met Glu Glu 
    850                 855                 860                 


Asn Ala Glu Asn His Ile Gly Val Thr Glu Val Leu Leu Gly Arg Lys 
865                 870                 875                 880 


Leu Gln His Tyr Thr Asp Ser Tyr Leu Gly Phe Leu Pro Trp Glu Lys 
                885                 890                 895     


Lys Lys Tyr Phe Gln Asp Leu Leu Asp Glu Glu Glu Ser Leu Lys Thr 
            900                 905                 910         


Gln Leu Ala Tyr Phe Thr Asp Ser Lys Asn Thr Gly Arg Gln Leu Lys 
        915                 920                 925             


Asp Thr Phe Ala Asp Ser Leu Arg Tyr Val Asn Lys Ile Leu Asn Ser 
    930                 935                 940                 


Lys Phe Gly Phe Thr Ser Arg Lys Val Pro Ala His Met Pro His Met 
945                 950                 955                 960 


Ile Asp Arg Ile Val Met Gln Glu Leu Gln Asp Met Phe Pro Glu Glu 
                965                 970                 975     


Phe Asp Lys Thr Ser Phe His Lys Val Arg His Ser Glu Asp Met Gln 
            980                 985                 990         


Phe Ala Phe Ser Tyr Phe Tyr Tyr  Leu Met Ser Ala Val  Gln Pro Leu 
        995                 1000                 1005             


Asn Ile  Ser Gln Val Phe Asp  Glu Val Asp Thr Asp  Gln Ser Gly 
    1010                 1015                 1020             


Val Leu  Ser Asp Arg Glu Ile  Arg Thr Leu Ala Thr  Arg Ile His 
    1025                 1030                 1035             


Glu Leu  Pro Leu Ser Leu Gln  Asp Leu Thr Gly Leu  Glu His Met 
    1040                 1045                 1050             


Leu Ile  Asn Cys Ser Lys Met  Leu Pro Ala Asp Ile  Thr Gln Leu 
    1055                 1060                 1065             


Asn Asn  Ile Pro Pro Thr Gln  Glu Ser Tyr Tyr Asp  Pro Asn Leu 
    1070                 1075                 1080             


Pro Pro  Val Thr Lys Ser Leu  Val Thr Asn Cys Lys  Pro Val Thr 
    1085                 1090                 1095             


Asp Lys  Ile His Lys Ala Tyr  Lys Asp Lys Asn Lys  Tyr Arg Phe 
    1100                 1105                 1110             


Glu Ile  Met Gly Glu Glu Glu  Ile Ala Phe Lys Met  Ile Arg Thr 
    1115                 1120                 1125             


Asn Val  Ser His Val Val Gly  Gln Leu Asp Asp Ile  Arg Lys Asn 
    1130                 1135                 1140             


Pro Arg  Lys Phe Val Cys Leu  Asn Asp Asn Ile Asp  His Asn His 
    1145                 1150                 1155             


Lys Asp  Ala Gln Thr Val Lys  Ala Val Leu Arg Asp  Phe Tyr Glu 
    1160                 1165                 1170             


Ser Met  Phe Pro Ile Pro Ser  Gln Phe Glu Leu Pro  Arg Glu Tyr 
    1175                 1180                 1185             


Arg Asn  Arg Phe Leu His Met  His Glu Leu Gln Glu  Trp Arg Ala 
    1190                 1195                 1200             


Tyr Arg  Asp Lys Leu Lys Phe  Trp Thr His Cys Val  Leu Ala Thr 
    1205                 1210                 1215             


Leu Ile  Met Phe Thr Ile Phe  Ser Phe Phe Ala Glu  Gln Leu Ile 
    1220                 1225                 1230             


Ala Leu  Lys Arg Lys Ile Phe  Pro Arg Arg Arg Ile  His Lys Glu 
    1235                 1240                 1245             


Ala Ser  Pro Asn Arg Ile Arg  Val 
    1250                 1255     


<210>  5024
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  5024

Met Glu Asp Phe Ala Thr Arg Thr Tyr Gly Thr Ser Gly Leu Asp Asn 
1               5                   10                  15      


Arg Pro Leu Phe Gly Glu Thr Ser Ala Lys Asp Arg Ile Ile Asn Leu 
            20                  25                  30          


Val Val Gly Ser Leu Thr Ser Leu Leu Ile Leu Val Thr Leu Ile Ser 
        35                  40                  45              


Ala Phe Val Phe Pro Gln Leu Pro Pro Lys Pro Leu Asn Ile Phe Phe 
    50                  55                  60                  


Ala Val Cys Ile Ser Leu Ser Ser Ile Thr Ala Cys Ile Leu Ile Tyr 
65                  70                  75                  80  


Trp Tyr Arg Gln Gly Asp Leu Glu Pro Lys Phe Arg Lys Leu Ile Tyr 
                85                  90                  95      


Tyr Ile Ile Phe Ser Ile Ile Met Leu Cys Ile Cys Ala Asn Leu Tyr 
            100                 105                 110         


Phe His Asp Val Gly Arg 
        115             


<210>  5025
<211>  730
<212>  PRT
<213>  Homo sapiens

<400>  5025

Met Gly Val Cys Gln Arg Thr Arg Ala Pro Trp Lys Glu Lys Ser Gln 
1               5                   10                  15      


Leu Glu Arg Ala Ala Leu Gly Phe Arg Lys Gly Gly Ser Gly Met Phe 
            20                  25                  30          


Ala Ser Gly Trp Asn Gln Thr Val Pro Ile Glu Glu Ala Gly Ser Met 
        35                  40                  45              


Ala Ala Leu Leu Leu Leu Pro Leu Leu Leu Leu Leu Pro Leu Leu Leu 
    50                  55                  60                  


Leu Lys Leu His Leu Trp Pro Gln Leu Arg Trp Leu Pro Ala Asp Leu 
65                  70                  75                  80  


Ala Phe Ala Val Arg Ala Leu Cys Cys Lys Arg Ala Leu Arg Ala Arg 
                85                  90                  95      


Ala Leu Ala Ala Ala Ala Ala Asp Pro Glu Gly Pro Glu Gly Gly Cys 
            100                 105                 110         


Ser Leu Ala Trp Arg Leu Ala Glu Leu Ala Gln Gln Arg Ala Ala His 
        115                 120                 125             


Thr Phe Leu Ile His Gly Ser Arg Arg Phe Ser Tyr Ser Glu Ala Glu 
    130                 135                 140                 


Arg Glu Ser Asn Arg Ala Ala Arg Ala Phe Leu Arg Ala Leu Gly Trp 
145                 150                 155                 160 


Asp Trp Gly Pro Asp Gly Gly Asp Ser Gly Glu Gly Ser Ala Gly Glu 
                165                 170                 175     


Gly Glu Arg Ala Ala Pro Gly Ala Gly Asp Ala Ala Ala Gly Ser Gly 
            180                 185                 190         


Ala Glu Phe Ala Gly Gly Asp Gly Ala Ala Arg Gly Gly Gly Ala Ala 
        195                 200                 205             


Ala Pro Leu Ser Pro Gly Ala Thr Val Ala Leu Leu Leu Pro Ala Gly 
    210                 215                 220                 


Pro Glu Phe Leu Trp Leu Trp Phe Gly Leu Ala Lys Ala Gly Leu Arg 
225                 230                 235                 240 


Thr Ala Phe Val Pro Thr Ala Leu Arg Arg Gly Pro Leu Leu His Cys 
                245                 250                 255     


Leu Arg Ser Cys Gly Ala Arg Ala Leu Val Leu Ala Pro Glu Phe Leu 
            260                 265                 270         


Glu Ser Leu Glu Pro Asp Leu Pro Ala Leu Arg Ala Met Gly Leu His 
        275                 280                 285             


Leu Trp Ala Ala Gly Pro Gly Thr His Pro Ala Gly Ile Ser Asp Leu 
    290                 295                 300                 


Leu Ala Glu Val Ser Ala Glu Val Asp Gly Pro Val Pro Gly Tyr Leu 
305                 310                 315                 320 


Ser Ser Pro Gln Ser Ile Thr Asp Thr Cys Leu Tyr Ile Phe Thr Ser 
                325                 330                 335     


Gly Thr Thr Gly Leu Pro Lys Ala Ala Arg Ile Ser His Leu Lys Ile 
            340                 345                 350         


Leu Gln Cys Gln Gly Phe Tyr Gln Leu Cys Gly Val His Gln Glu Asp 
        355                 360                 365             


Val Ile Tyr Leu Ala Leu Pro Leu Tyr His Met Ser Gly Ser Leu Leu 
    370                 375                 380                 


Gly Ile Val Gly Cys Met Gly Ile Gly Ala Thr Val Val Leu Lys Ser 
385                 390                 395                 400 


Lys Phe Ser Ala Gly Gln Phe Trp Glu Asp Cys Gln Gln His Arg Val 
                405                 410                 415     


Thr Val Phe Gln Tyr Ile Gly Glu Leu Cys Arg Tyr Leu Val Asn Gln 
            420                 425                 430         


Pro Pro Ser Lys Ala Glu Arg Gly His Lys Val Arg Leu Ala Val Gly 
        435                 440                 445             


Ser Gly Leu Arg Pro Asp Thr Trp Glu Arg Phe Val Arg Arg Phe Gly 
    450                 455                 460                 


Pro Leu Gln Val Leu Glu Thr Tyr Gly Leu Thr Glu Gly Asn Val Ala 
465                 470                 475                 480 


Thr Ile Asn Tyr Thr Gly Gln Arg Gly Ala Val Gly Arg Ala Ser Trp 
                485                 490                 495     


Leu Tyr Lys His Ile Phe Pro Phe Ser Leu Ile Arg Tyr Asp Val Thr 
            500                 505                 510         


Thr Gly Glu Pro Ile Arg Asp Pro Gln Gly His Cys Met Ala Thr Ser 
        515                 520                 525             


Pro Gly Glu Pro Gly Leu Leu Val Ala Pro Val Ser Gln Gln Ser Pro 
    530                 535                 540                 


Phe Leu Gly Tyr Ala Gly Gly Pro Glu Leu Ala Gln Gly Lys Leu Leu 
545                 550                 555                 560 


Lys Asp Val Phe Arg Pro Gly Asp Val Phe Phe Asn Thr Gly Asp Leu 
                565                 570                 575     


Leu Val Cys Asp Asp Gln Gly Phe Leu Arg Phe His Asp Arg Thr Gly 
            580                 585                 590         


Asp Thr Phe Arg Trp Lys Gly Glu Asn Val Ala Thr Thr Glu Val Ala 
        595                 600                 605             


Glu Val Phe Glu Ala Leu Asp Phe Leu Gln Glu Val Asn Val Tyr Gly 
    610                 615                 620                 


Val Thr Val Pro Gly His Glu Gly Arg Ala Gly Met Ala Ala Leu Val 
625                 630                 635                 640 


Leu Arg Pro Pro His Ala Leu Asp Leu Met Gln Leu Tyr Thr His Val 
                645                 650                 655     


Ser Glu Asn Leu Pro Pro Tyr Ala Arg Pro Arg Phe Leu Arg Leu Gln 
            660                 665                 670         


Glu Ser Leu Ala Thr Thr Glu Thr Phe Lys Gln Gln Lys Val Arg Met 
        675                 680                 685             


Ala Asn Glu Gly Phe Asp Pro Ser Thr Leu Ser Asp Pro Leu Tyr Val 
    690                 695                 700                 


Leu Asp Gln Ala Val Gly Ala Tyr Leu Pro Leu Thr Thr Ala Arg Tyr 
705                 710                 715                 720 


Ser Ala Leu Leu Ala Gly Asn Leu Arg Ile 
                725                 730 


<210>  5026
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  5026

Met Ala Ala Asn Tyr Ser Ser Thr Ser Thr Arg Arg Glu His Val Lys 
1               5                   10                  15      


Val Lys Thr Ser Ser Gln Pro Gly Phe Leu Glu Arg Leu Ser Glu Thr 
            20                  25                  30          


Ser Gly Gly Met Phe Val Gly Leu Met Ala Phe Leu Leu Ser Phe Tyr 
        35                  40                  45              


Leu Ile Phe Thr Asn Glu Gly Arg Ala Leu Lys Thr Ala Thr Ser Leu 
    50                  55                  60                  


Ala Glu Gly Leu Ser Leu Val Val Ser Pro Asp Ser Ile His Ser Val 
65                  70                  75                  80  


Ala Pro Glu Asn Glu Gly Arg Leu Val His Ile Ile Gly Ala Leu Arg 
                85                  90                  95      


Thr Ser Lys Leu Leu Ser Asp Pro Asn Tyr Gly Val His Leu Pro Ala 
            100                 105                 110         


Val Lys Leu Arg Arg His Val Glu Met Tyr Gln Trp Val Glu Thr Glu 
        115                 120                 125             


Glu Ser Arg Glu Tyr Thr Glu Asp Gly Gln Val Lys Lys Glu Thr Arg 
    130                 135                 140                 


Tyr Ser Tyr Asn Thr Glu Trp Arg Ser Glu Ile Ile Asn Ser Lys Asn 
145                 150                 155                 160 


Phe Asp Arg Glu Ile Gly His Lys Asn Pro Ser Ala Met Ala Val Glu 
                165                 170                 175     


Ser Phe Met Ala Thr Ala Pro Phe Val Gln Ile Gly Arg Phe Phe Leu 
            180                 185                 190         


Ser Ser Gly Leu Ile Asp Lys Val Asp Asn Phe Lys Ser Leu Ser Leu 
        195                 200                 205             


Ser Lys Leu Glu Asp Pro His Val Asp Ile Ile Arg Arg Gly Asp Phe 
    210                 215                 220                 


Phe Tyr His Ser Glu Asn Pro Lys Tyr Pro Glu Val Gly Asp Leu Arg 
225                 230                 235                 240 


Val Ser Phe Ser Tyr Ala Gly Leu Ser Gly Asp Asp Pro Asp Leu Gly 
                245                 250                 255     


Pro Ala His Val Val Thr Val Ile Ala Arg Gln Arg Gly Asp Gln Leu 
            260                 265                 270         


Val Pro Phe Ser Thr Lys Ser Gly Asp Thr Leu Leu Leu Leu His His 
        275                 280                 285             


Gly Asp Phe Ser Ala Glu Glu Val Phe His Arg Glu Leu Arg Ser Asn 
    290                 295                 300                 


Ser Met Lys Thr Trp Gly Leu Arg Ala Ala Gly Trp Met Ala Met Phe 
305                 310                 315                 320 


Met Gly Leu Asn Leu Met Thr Arg Ile Leu Tyr Thr Leu Val Asp Trp 
                325                 330                 335     


Phe Pro Val Phe Arg Asp Leu Val Asn Ile Gly Leu Lys Ala Phe Ala 
            340                 345                 350         


Phe Cys Val Ala Thr Ser Leu Thr Leu Leu Thr Val Ala Ala Gly Trp 
        355                 360                 365             


Leu Phe Tyr Arg Pro Leu Trp Ala Leu Leu Ile Ala Gly Leu Ala Leu 
    370                 375                 380                 


Val Pro Ile Leu Val Ala Arg Thr Arg Val Pro Ala Lys Lys Leu Glu 
385                 390                 395                 400 


<210>  5027
<211>  2471
<212>  PRT
<213>  Homo sapiens

<400>  5027

Met Pro Ala Leu Arg Pro Ala Leu Leu Trp Ala Leu Leu Ala Leu Trp 
1               5                   10                  15      


Leu Cys Cys Ala Ala Pro Ala His Ala Leu Gln Cys Arg Asp Gly Tyr 
            20                  25                  30          


Glu Pro Cys Val Asn Glu Gly Met Cys Val Thr Tyr His Asn Gly Thr 
        35                  40                  45              


Gly Tyr Cys Lys Cys Pro Glu Gly Phe Leu Gly Glu Tyr Cys Gln His 
    50                  55                  60                  


Arg Asp Pro Cys Glu Lys Asn Arg Cys Gln Asn Gly Gly Thr Cys Val 
65                  70                  75                  80  


Ala Gln Ala Met Leu Gly Lys Ala Thr Cys Arg Cys Ala Ser Gly Phe 
                85                  90                  95      


Thr Gly Glu Asp Cys Gln Tyr Ser Thr Ser His Pro Cys Phe Val Ser 
            100                 105                 110         


Arg Pro Cys Leu Asn Gly Gly Thr Cys His Met Leu Ser Arg Asp Thr 
        115                 120                 125             


Tyr Glu Cys Thr Cys Gln Val Gly Phe Thr Gly Lys Glu Cys Gln Trp 
    130                 135                 140                 


Thr Asp Ala Cys Leu Ser His Pro Cys Ala Asn Gly Ser Thr Cys Thr 
145                 150                 155                 160 


Thr Val Ala Asn Gln Phe Ser Cys Lys Cys Leu Thr Gly Phe Thr Gly 
                165                 170                 175     


Gln Lys Cys Glu Thr Asp Val Asn Glu Cys Asp Ile Pro Gly His Cys 
            180                 185                 190         


Gln His Gly Gly Thr Cys Leu Asn Leu Pro Gly Ser Tyr Gln Cys Gln 
        195                 200                 205             


Cys Pro Gln Gly Phe Thr Gly Gln Tyr Cys Asp Ser Leu Tyr Val Pro 
    210                 215                 220                 


Cys Ala Pro Ser Pro Cys Val Asn Gly Gly Thr Cys Arg Gln Thr Gly 
225                 230                 235                 240 


Asp Phe Thr Phe Glu Cys Asn Cys Leu Pro Gly Phe Glu Gly Ser Thr 
                245                 250                 255     


Cys Glu Arg Asn Ile Asp Asp Cys Pro Asn His Arg Cys Gln Asn Gly 
            260                 265                 270         


Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro 
        275                 280                 285             


Gln Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu 
    290                 295                 300                 


Gln Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Ala Asn Arg Asn Gly 
305                 310                 315                 320 


Gly Tyr Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser 
                325                 330                 335     


Glu Asn Ile Asp Asp Cys Ala Phe Ala Ser Cys Thr Pro Gly Ser Thr 
            340                 345                 350         


Cys Ile Asp Arg Val Ala Ser Phe Ser Cys Met Cys Pro Glu Gly Lys 
        355                 360                 365             


Ala Gly Leu Leu Cys His Leu Asp Asp Ala Cys Ile Ser Asn Pro Cys 
    370                 375                 380                 


His Lys Gly Ala Leu Cys Asp Thr Asn Pro Leu Asn Gly Gln Tyr Ile 
385                 390                 395                 400 


Cys Thr Cys Pro Gln Gly Tyr Lys Gly Ala Asp Cys Thr Glu Asp Val 
                405                 410                 415     


Asp Glu Cys Ala Met Ala Asn Ser Asn Pro Cys Glu His Ala Gly Lys 
            420                 425                 430         


Cys Val Asn Thr Asp Gly Ala Phe His Cys Glu Cys Leu Lys Gly Tyr 
        435                 440                 445             


Ala Gly Pro Arg Cys Glu Met Asp Ile Asn Glu Cys His Ser Asp Pro 
    450                 455                 460                 


Cys Gln Asn Asp Ala Thr Cys Leu Asp Lys Ile Gly Gly Phe Thr Cys 
465                 470                 475                 480 


Leu Cys Met Pro Gly Phe Lys Gly Val His Cys Glu Leu Glu Ile Asn 
                485                 490                 495     


Glu Cys Gln Ser Asn Pro Cys Val Asn Asn Gly Gln Cys Val Asp Lys 
            500                 505                 510         


Val Asn Arg Phe Gln Cys Leu Cys Pro Pro Gly Phe Thr Gly Pro Val 
        515                 520                 525             


Cys Gln Ile Asp Ile Asp Asp Cys Ser Ser Thr Pro Cys Leu Asn Gly 
    530                 535                 540                 


Ala Lys Cys Ile Asp His Pro Asn Gly Tyr Glu Cys Gln Cys Ala Thr 
545                 550                 555                 560 


Gly Phe Thr Gly Val Leu Cys Glu Glu Asn Ile Asp Asn Cys Asp Pro 
                565                 570                 575     


Asp Pro Cys His His Gly Gln Cys Gln Asp Gly Ile Asp Ser Tyr Thr 
            580                 585                 590         


Cys Ile Cys Asn Pro Gly Tyr Met Gly Ala Ile Cys Ser Asp Gln Ile 
        595                 600                 605             


Asp Glu Cys Tyr Ser Ser Pro Cys Leu Asn Asp Gly Arg Cys Ile Asp 
    610                 615                 620                 


Leu Val Asn Gly Tyr Gln Cys Asn Cys Gln Pro Gly Thr Ser Gly Val 
625                 630                 635                 640 


Asn Cys Glu Ile Asn Phe Asp Asp Cys Ala Ser Asn Pro Cys Ile His 
                645                 650                 655     


Gly Ile Cys Met Asp Gly Ile Asn Arg Tyr Ser Cys Val Cys Ser Pro 
            660                 665                 670         


Gly Phe Thr Gly Gln Arg Cys Asn Ile Asp Ile Asp Glu Cys Ala Ser 
        675                 680                 685             


Asn Pro Cys Arg Lys Gly Ala Thr Cys Ile Asn Gly Val Asn Gly Phe 
    690                 695                 700                 


Arg Cys Ile Cys Pro Glu Gly Pro His His Pro Ser Cys Tyr Ser Gln 
705                 710                 715                 720 


Val Asn Glu Cys Leu Ser Asn Pro Cys Ile His Gly Asn Cys Thr Gly 
                725                 730                 735     


Gly Leu Ser Gly Tyr Lys Cys Leu Cys Asp Ala Gly Trp Val Gly Ile 
            740                 745                 750         


Asn Cys Glu Val Asp Lys Asn Glu Cys Leu Ser Asn Pro Cys Gln Asn 
        755                 760                 765             


Gly Gly Thr Cys Asp Asn Leu Val Asn Gly Tyr Arg Cys Thr Cys Lys 
    770                 775                 780                 


Lys Gly Phe Lys Gly Tyr Asn Cys Gln Val Asn Ile Asp Glu Cys Ala 
785                 790                 795                 800 


Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Phe Asp Asp Ile Ser Gly 
                805                 810                 815     


Tyr Thr Cys His Cys Val Leu Pro Tyr Thr Gly Lys Asn Cys Gln Thr 
            820                 825                 830         


Val Leu Ala Pro Cys Ser Pro Asn Pro Cys Glu Asn Ala Ala Val Cys 
        835                 840                 845             


Lys Glu Ser Pro Asn Phe Glu Ser Tyr Thr Cys Leu Cys Ala Pro Gly 
    850                 855                 860                 


Trp Gln Gly Gln Arg Cys Thr Ile Asp Ile Asp Glu Cys Ile Ser Lys 
865                 870                 875                 880 


Pro Cys Met Asn His Gly Leu Cys His Asn Thr Gln Gly Ser Tyr Met 
                885                 890                 895     


Cys Glu Cys Pro Pro Gly Phe Ser Gly Met Asp Cys Glu Glu Asp Ile 
            900                 905                 910         


Asp Asp Cys Leu Ala Asn Pro Cys Gln Asn Gly Gly Ser Cys Met Asp 
        915                 920                 925             


Gly Val Asn Thr Phe Ser Cys Leu Cys Leu Pro Gly Phe Thr Gly Asp 
    930                 935                 940                 


Lys Cys Gln Thr Asp Met Asn Glu Cys Leu Ser Glu Pro Cys Lys Asn 
945                 950                 955                 960 


Gly Gly Thr Cys Ser Asp Tyr Val Asn Ser Tyr Thr Cys Lys Cys Gln 
                965                 970                 975     


Ala Gly Phe Asp Gly Val His Cys Glu Asn Asn Ile Asn Glu Cys Thr 
            980                 985                 990         


Glu Ser Ser Cys Phe Asn Gly Gly  Thr Cys Val Asp Gly  Ile Asn Ser 
        995                 1000                 1005             


Phe Ser  Cys Leu Cys Pro Val  Gly Phe Thr Gly Ser  Phe Cys Leu 
    1010                 1015                 1020             


His Glu  Ile Asn Glu Cys Ser  Ser His Pro Cys Leu  Asn Glu Gly 
    1025                 1030                 1035             


Thr Cys  Val Asp Gly Leu Gly  Thr Tyr Arg Cys Ser  Cys Pro Leu 
    1040                 1045                 1050             


Gly Tyr  Thr Gly Lys Asn Cys  Gln Thr Leu Val Asn  Leu Cys Ser 
    1055                 1060                 1065             


Arg Ser  Pro Cys Lys Asn Lys  Gly Thr Cys Val Gln  Lys Lys Ala 
    1070                 1075                 1080             


Glu Ser  Gln Cys Leu Cys Pro  Ser Gly Trp Ala Gly  Ala Tyr Cys 
    1085                 1090                 1095             


Asp Val  Pro Asn Val Ser Cys  Asp Ile Ala Ala Ser  Arg Arg Gly 
    1100                 1105                 1110             


Val Leu  Val Glu His Leu Cys  Gln His Ser Gly Val  Cys Ile Asn 
    1115                 1120                 1125             


Ala Gly  Asn Thr His Tyr Cys  Gln Cys Pro Leu Gly  Tyr Thr Gly 
    1130                 1135                 1140             


Ser Tyr  Cys Glu Glu Gln Leu  Asp Glu Cys Ala Ser  Asn Pro Cys 
    1145                 1150                 1155             


Gln His  Gly Ala Thr Cys Ser  Asp Phe Ile Gly Gly  Tyr Arg Cys 
    1160                 1165                 1170             


Glu Cys  Val Pro Gly Tyr Gln  Gly Val Asn Cys Glu  Tyr Glu Val 
    1175                 1180                 1185             


Asp Glu  Cys Gln Asn Gln Pro  Cys Gln Asn Gly Gly  Thr Cys Ile 
    1190                 1195                 1200             


Asp Leu  Val Asn His Phe Lys  Cys Ser Cys Pro Pro  Gly Thr Arg 
    1205                 1210                 1215             


Gly Leu  Leu Cys Glu Glu Asn  Ile Asp Asp Cys Ala  Arg Gly Pro 
    1220                 1225                 1230             


His Cys  Leu Asn Gly Gly Gln  Cys Met Asp Arg Ile  Gly Gly Tyr 
    1235                 1240                 1245             


Ser Cys  Arg Cys Leu Pro Gly  Phe Ala Gly Glu Arg  Cys Glu Gly 
    1250                 1255                 1260             


Asp Ile  Asn Glu Cys Leu Ser  Asn Pro Cys Ser Ser  Glu Gly Ser 
    1265                 1270                 1275             


Leu Asp  Cys Ile Gln Leu Thr  Asn Asp Tyr Leu Cys  Val Cys Arg 
    1280                 1285                 1290             


Ser Ala  Phe Thr Gly Arg His  Cys Glu Thr Phe Val  Asp Val Cys 
    1295                 1300                 1305             


Pro Gln  Met Pro Cys Leu Asn  Gly Gly Thr Cys Ala  Val Ala Ser 
    1310                 1315                 1320             


Asn Met  Pro Asp Gly Phe Ile  Cys Arg Cys Pro Pro  Gly Phe Ser 
    1325                 1330                 1335             


Gly Ala  Arg Cys Gln Ser Ser  Cys Gly Gln Val Lys  Cys Arg Lys 
    1340                 1345                 1350             


Gly Glu  Gln Cys Val His Thr  Ala Ser Gly Pro Arg  Cys Phe Cys 
    1355                 1360                 1365             


Pro Ser  Pro Arg Asp Cys Glu  Ser Gly Cys Ala Ser  Ser Pro Cys 
    1370                 1375                 1380             


Gln His  Gly Gly Ser Cys His  Pro Gln Arg Gln Pro  Pro Tyr Tyr 
    1385                 1390                 1395             


Ser Cys  Gln Cys Ala Pro Pro  Phe Ser Gly Ser Arg  Cys Glu Leu 
    1400                 1405                 1410             


Tyr Thr  Ala Pro Pro Ser Thr  Pro Pro Ala Thr Cys  Leu Ser Gln 
    1415                 1420                 1425             


Tyr Cys  Ala Asp Lys Ala Arg  Asp Gly Val Cys Asp  Glu Ala Cys 
    1430                 1435                 1440             


Asn Ser  His Ala Cys Gln Trp  Asp Gly Gly Asp Cys  Ser Leu Thr 
    1445                 1450                 1455             


Met Glu  Asn Pro Trp Ala Asn  Cys Ser Ser Pro Leu  Pro Cys Trp 
    1460                 1465                 1470             


Asp Tyr  Ile Asn Asn Gln Cys  Asp Glu Leu Cys Asn  Thr Val Glu 
    1475                 1480                 1485             


Cys Leu  Phe Asp Asn Phe Glu  Cys Gln Gly Asn Ser  Lys Thr Cys 
    1490                 1495                 1500             


Lys Tyr  Asp Lys Tyr Cys Ala  Asp His Phe Lys Asp  Asn His Cys 
    1505                 1510                 1515             


Asp Gln  Gly Cys Asn Ser Glu  Glu Cys Gly Trp Asp  Gly Leu Asp 
    1520                 1525                 1530             


Cys Ala  Ala Asp Gln Pro Glu  Asn Leu Ala Glu Gly  Thr Leu Val 
    1535                 1540                 1545             


Ile Val  Val Leu Met Pro Pro  Glu Gln Leu Leu Gln  Asp Ala Arg 
    1550                 1555                 1560             


Ser Phe  Leu Arg Ala Leu Gly  Thr Leu Leu His Thr  Asn Leu Arg 
    1565                 1570                 1575             


Ile Lys  Arg Asp Ser Gln Gly  Glu Leu Met Val Tyr  Pro Tyr Tyr 
    1580                 1585                 1590             


Gly Glu  Lys Ser Ala Ala Met  Lys Lys Gln Arg Met  Thr Arg Arg 
    1595                 1600                 1605             


Ser Leu  Pro Gly Glu Gln Glu  Gln Glu Val Ala Gly  Ser Lys Val 
    1610                 1615                 1620             


Phe Leu  Glu Ile Asp Asn Arg  Gln Cys Val Gln Asp  Ser Asp His 
    1625                 1630                 1635             


Cys Phe  Lys Asn Thr Asp Ala  Ala Ala Ala Leu Leu  Ala Ser His 
    1640                 1645                 1650             


Ala Ile  Gln Gly Thr Leu Ser  Tyr Pro Leu Val Ser  Val Val Ser 
    1655                 1660                 1665             


Glu Ser  Leu Thr Pro Glu Arg  Thr Gln Leu Leu Tyr  Leu Leu Ala 
    1670                 1675                 1680             


Val Ala  Val Val Ile Ile Leu  Phe Ile Ile Leu Leu  Gly Val Ile 
    1685                 1690                 1695             


Met Ala  Lys Arg Lys Arg Lys  His Gly Ser Leu Trp  Leu Pro Glu 
    1700                 1705                 1710             


Gly Phe  Thr Leu Arg Arg Asp  Ala Ser Asn His Lys  Arg Arg Glu 
    1715                 1720                 1725             


Pro Val  Gly Gln Asp Ala Val  Gly Leu Lys Asn Leu  Ser Val Gln 
    1730                 1735                 1740             


Val Ser  Glu Ala Asn Leu Ile  Gly Thr Gly Thr Ser  Glu His Trp 
    1745                 1750                 1755             


Val Asp  Asp Glu Gly Pro Gln  Pro Lys Lys Val Lys  Ala Glu Asp 
    1760                 1765                 1770             


Glu Ala  Leu Leu Ser Glu Glu  Asp Asp Pro Ile Asp  Arg Arg Pro 
    1775                 1780                 1785             


Trp Thr  Gln Gln His Leu Glu  Ala Ala Asp Ile Arg  Arg Thr Pro 
    1790                 1795                 1800             


Ser Leu  Ala Leu Thr Pro Pro  Gln Ala Glu Gln Glu  Val Asp Val 
    1805                 1810                 1815             


Leu Asp  Val Asn Val Arg Gly  Pro Asp Gly Cys Thr  Pro Leu Met 
    1820                 1825                 1830             


Leu Ala  Ser Leu Arg Gly Gly  Ser Ser Asp Leu Ser  Asp Glu Asp 
    1835                 1840                 1845             


Glu Asp  Ala Glu Asp Ser Ser  Ala Asn Ile Ile Thr  Asp Leu Val 
    1850                 1855                 1860             


Tyr Gln  Gly Ala Ser Leu Gln  Ala Gln Thr Asp Arg  Thr Gly Glu 
    1865                 1870                 1875             


Met Ala  Leu His Leu Ala Ala  Arg Tyr Ser Arg Ala  Asp Ala Ala 
    1880                 1885                 1890             


Lys Arg  Leu Leu Asp Ala Gly  Ala Asp Ala Asn Ala  Gln Asp Asn 
    1895                 1900                 1905             


Met Gly  Arg Cys Pro Leu His  Ala Ala Val Ala Ala  Asp Ala Gln 
    1910                 1915                 1920             


Gly Val  Phe Gln Ile Leu Ile  Arg Asn Arg Val Thr  Asp Leu Asp 
    1925                 1930                 1935             


Ala Arg  Met Asn Asp Gly Thr  Thr Pro Leu Ile Leu  Ala Ala Arg 
    1940                 1945                 1950             


Leu Ala  Val Glu Gly Met Val  Ala Glu Leu Ile Asn  Cys Gln Ala 
    1955                 1960                 1965             


Asp Val  Asn Ala Val Asp Asp  His Gly Lys Ser Ala  Leu His Trp 
    1970                 1975                 1980             


Ala Ala  Ala Val Asn Asn Val  Glu Ala Thr Leu Leu  Leu Leu Lys 
    1985                 1990                 1995             


Asn Gly  Ala Asn Arg Asp Met  Gln Asp Asn Lys Glu  Glu Thr Pro 
    2000                 2005                 2010             


Leu Phe  Leu Ala Ala Arg Glu  Gly Ser Tyr Glu Ala  Ala Lys Ile 
    2015                 2020                 2025             


Leu Leu  Asp His Phe Ala Asn  Arg Asp Ile Thr Asp  His Met Asp 
    2030                 2035                 2040             


Arg Leu  Pro Arg Asp Val Ala  Arg Asp Arg Met His  His Asp Ile 
    2045                 2050                 2055             


Val Arg  Leu Leu Asp Glu Tyr  Asn Val Thr Pro Ser  Pro Pro Gly 
    2060                 2065                 2070             


Thr Val  Leu Thr Ser Ala Leu  Ser Pro Val Ile Cys  Gly Pro Asn 
    2075                 2080                 2085             


Arg Ser  Phe Leu Ser Leu Lys  His Thr Pro Met Gly  Lys Lys Ser 
    2090                 2095                 2100             


Arg Arg  Pro Ser Ala Lys Ser  Thr Met Pro Thr Ser  Leu Pro Asn 
    2105                 2110                 2115             


Leu Ala  Lys Glu Ala Lys Asp  Ala Lys Gly Ser Arg  Arg Lys Lys 
    2120                 2125                 2130             


Ser Leu  Ser Glu Lys Val Gln  Leu Ser Glu Ser Ser  Val Thr Leu 
    2135                 2140                 2145             


Ser Pro  Val Asp Ser Leu Glu  Ser Pro His Thr Tyr  Val Ser Asp 
    2150                 2155                 2160             


Thr Thr  Ser Ser Pro Met Ile  Thr Ser Pro Gly Ile  Leu Gln Ala 
    2165                 2170                 2175             


Ser Pro  Asn Pro Met Leu Ala  Thr Ala Ala Pro Pro  Ala Pro Val 
    2180                 2185                 2190             


His Ala  Gln His Ala Leu Ser  Phe Ser Asn Leu His  Glu Met Gln 
    2195                 2200                 2205             


Pro Leu  Ala His Gly Ala Ser  Thr Val Leu Pro Ser  Val Ser Gln 
    2210                 2215                 2220             


Leu Leu  Ser His His His Ile  Val Ser Pro Gly Ser  Gly Ser Ala 
    2225                 2230                 2235             


Gly Ser  Leu Ser Arg Leu His  Pro Val Pro Val Pro  Ala Asp Trp 
    2240                 2245                 2250             


Met Asn  Arg Met Glu Val Asn  Glu Thr Gln Tyr Asn  Glu Met Phe 
    2255                 2260                 2265             


Gly Met  Val Leu Ala Pro Ala  Glu Gly Thr His Pro  Gly Ile Ala 
    2270                 2275                 2280             


Pro Gln  Ser Arg Pro Pro Glu  Gly Lys His Ile Thr  Thr Pro Arg 
    2285                 2290                 2295             


Glu Pro  Leu Pro Pro Ile Val  Thr Phe Gln Leu Ile  Pro Lys Gly 
    2300                 2305                 2310             


Ser Ile  Ala Gln Pro Ala Gly  Ala Pro Gln Pro Gln  Ser Thr Cys 
    2315                 2320                 2325             


Pro Pro  Ala Val Ala Gly Pro  Leu Pro Thr Met Tyr  Gln Ile Pro 
    2330                 2335                 2340             


Glu Met  Ala Arg Leu Pro Ser  Val Ala Phe Pro Thr  Ala Met Met 
    2345                 2350                 2355             


Pro Gln  Gln Asp Gly Gln Val  Ala Gln Thr Ile Leu  Pro Ala Tyr 
    2360                 2365                 2370             


His Pro  Phe Pro Ala Ser Val  Gly Lys Tyr Pro Thr  Pro Pro Ser 
    2375                 2380                 2385             


Gln His  Ser Tyr Ala Ser Ser  Asn Ala Ala Glu Arg  Thr Pro Ser 
    2390                 2395                 2400             


His Ser  Gly His Leu Gln Gly  Glu His Pro Tyr Leu  Thr Pro Ser 
    2405                 2410                 2415             


Pro Glu  Ser Pro Asp Gln Trp  Ser Ser Ser Ser Pro  His Ser Ala 
    2420                 2425                 2430             


Ser Asp  Trp Ser Asp Val Thr  Thr Ser Pro Thr Pro  Gly Gly Ala 
    2435                 2440                 2445             


Gly Gly  Gly Gln Arg Gly Pro  Gly Thr His Met Ser  Glu Pro Pro 
    2450                 2455                 2460             


His Asn  Asn Met Gln Val Tyr  Ala 
    2465                 2470     


<210>  5028
<211>  894
<212>  PRT
<213>  Homo sapiens

<400>  5028

Met Ala Leu Ala Ser Ala Ala Pro Gly Ser Ile Phe Cys Lys Gln Leu 
1               5                   10                  15      


Leu Phe Ser Leu Leu Val Leu Thr Leu Leu Cys Asp Ala Cys Gln Lys 
            20                  25                  30          


Val Tyr Leu Arg Val Pro Ser His Leu Gln Ala Glu Thr Leu Val Gly 
        35                  40                  45              


Lys Val Asn Leu Glu Glu Cys Leu Lys Ser Ala Ser Leu Ile Arg Ser 
    50                  55                  60                  


Ser Asp Pro Ala Phe Arg Ile Leu Glu Asp Gly Ser Ile Tyr Thr Thr 
65                  70                  75                  80  


His Asp Leu Ile Leu Ser Ser Glu Arg Lys Ser Phe Ser Ile Phe Leu 
                85                  90                  95      


Ser Asp Gly Gln Arg Arg Glu Gln Gln Glu Ile Lys Val Val Leu Ser 
            100                 105                 110         


Ala Arg Glu Asn Lys Ser Pro Lys Lys Arg His Thr Lys Asp Thr Ala 
        115                 120                 125             


Leu Lys Arg Ser Lys Arg Arg Trp Ala Pro Ile Pro Ala Ser Leu Met 
    130                 135                 140                 


Glu Asn Ser Leu Gly Pro Phe Pro Gln His Val Gln Gln Ile Gln Ser 
145                 150                 155                 160 


Asp Ala Ala Gln Asn Tyr Thr Ile Phe Tyr Ser Ile Ser Gly Pro Gly 
                165                 170                 175     


Val Asp Lys Glu Pro Phe Asn Leu Phe Tyr Ile Glu Lys Asp Thr Gly 
            180                 185                 190         


Asp Ile Phe Cys Thr Arg Ser Ile Asp Arg Glu Lys Tyr Glu Gln Phe 
        195                 200                 205             


Ala Leu Tyr Gly Tyr Ala Thr Thr Ala Asp Gly Tyr Ala Pro Glu Tyr 
    210                 215                 220                 


Pro Leu Pro Leu Ile Ile Lys Ile Glu Asp Asp Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Tyr Phe Glu His Arg Val Thr Ile Phe Thr Val Pro Glu Asn Cys Arg 
                245                 250                 255     


Ser Gly Thr Ser Val Gly Lys Val Thr Ala Thr Asp Leu Asp Glu Pro 
            260                 265                 270         


Asp Thr Leu His Thr Arg Leu Lys Tyr Lys Ile Leu Gln Gln Ile Pro 
        275                 280                 285             


Asp His Pro Lys His Phe Ser Ile His Pro Asp Thr Gly Val Ile Thr 
    290                 295                 300                 


Thr Thr Thr Pro Phe Leu Asp Arg Glu Lys Cys Asp Thr Tyr Gln Leu 
305                 310                 315                 320 


Ile Met Glu Val Arg Asp Met Gly Gly Gln Pro Phe Gly Leu Phe Asn 
                325                 330                 335     


Thr Gly Thr Ile Thr Ile Ser Leu Glu Asp Glu Asn Asp Asn Pro Pro 
            340                 345                 350         


Ser Phe Thr Glu Thr Ser Tyr Val Thr Glu Val Glu Glu Asn Arg Ile 
        355                 360                 365             


Asp Val Glu Ile Leu Arg Met Lys Val Gln Asp Gln Asp Leu Pro Asn 
    370                 375                 380                 


Thr Pro His Ser Lys Ala Val Tyr Lys Ile Leu Gln Gly Asn Glu Asn 
385                 390                 395                 400 


Gly Asn Phe Ile Ile Ser Thr Asp Pro Asn Thr Asn Glu Gly Val Leu 
                405                 410                 415     


Cys Val Val Lys Pro Leu Asn Tyr Glu Val Asn Arg Gln Val Ile Leu 
            420                 425                 430         


Gln Val Gly Val Ile Asn Glu Ala Gln Phe Ser Lys Ala Ala Ser Ser 
        435                 440                 445             


Gln Thr Pro Thr Met Cys Thr Thr Thr Val Thr Val Lys Ile Ile Asp 
    450                 455                 460                 


Ser Asp Glu Gly Pro Glu Cys His Pro Pro Val Lys Val Ile Gln Ser 
465                 470                 475                 480 


Gln Asp Gly Phe Pro Ala Gly Gln Glu Leu Leu Gly Tyr Lys Ala Leu 
                485                 490                 495     


Asp Pro Glu Ile Ser Ser Gly Glu Gly Leu Arg Tyr Gln Lys Leu Gly 
            500                 505                 510         


Asp Glu Asp Asn Trp Phe Glu Ile Asn Gln His Thr Gly Asp Leu Arg 
        515                 520                 525             


Thr Leu Lys Val Leu Asp Arg Glu Ser Lys Phe Val Lys Asn Asn Gln 
    530                 535                 540                 


Tyr Asn Ile Ser Val Val Ala Val Asp Ala Val Gly Arg Ser Cys Thr 
545                 550                 555                 560 


Gly Thr Leu Val Val His Leu Asp Asp Tyr Asn Asp His Ala Pro Gln 
                565                 570                 575     


Ile Asp Lys Glu Val Thr Ile Cys Gln Asn Asn Glu Asp Phe Ala Val 
            580                 585                 590         


Leu Lys Pro Val Asp Pro Asp Gly Pro Glu Asn Gly Pro Pro Phe Gln 
        595                 600                 605             


Phe Phe Leu Asp Asn Ser Ala Ser Lys Asn Trp Asn Ile Glu Glu Lys 
    610                 615                 620                 


Asp Gly Lys Thr Ala Ile Leu Arg Gln Arg Gln Asn Leu Asp Tyr Asn 
625                 630                 635                 640 


Tyr Tyr Ser Val Pro Ile Gln Ile Lys Asp Arg His Gly Leu Val Ala 
                645                 650                 655     


Thr His Met Leu Thr Val Arg Val Cys Asp Cys Ser Thr Pro Ser Glu 
            660                 665                 670         


Cys Arg Met Lys Asp Lys Ser Thr Arg Asp Val Arg Pro Asn Val Ile 
        675                 680                 685             


Leu Gly Arg Trp Ala Ile Leu Ala Met Val Leu Gly Ser Val Leu Leu 
    690                 695                 700                 


Leu Cys Ile Leu Phe Thr Cys Phe Cys Val Thr Ala Lys Arg Thr Val 
705                 710                 715                 720 


Lys Lys Cys Phe Pro Glu Asp Ile Ala Gln Gln Asn Leu Ile Val Ser 
                725                 730                 735     


Asn Thr Glu Gly Pro Gly Glu Glu Val Thr Glu Ala Asn Ile Arg Leu 
            740                 745                 750         


Pro Met Gln Thr Ser Asn Ile Cys Asp Thr Ser Met Ser Val Gly Thr 
        755                 760                 765             


Val Gly Gly Gln Gly Ile Lys Thr Gln Gln Ser Phe Glu Met Val Lys 
    770                 775                 780                 


Gly Gly Tyr Thr Leu Asp Ser Asn Lys Gly Gly Gly His Gln Thr Leu 
785                 790                 795                 800 


Glu Ser Val Lys Gly Val Gly Gln Gly Asp Thr Gly Arg Tyr Ala Tyr 
                805                 810                 815     


Thr Asp Trp Gln Ser Phe Thr Gln Pro Arg Leu Gly Glu Lys Val Tyr 
            820                 825                 830         


Leu Cys Gly Gln Asp Glu Glu His Lys His Cys Glu Asp Tyr Val Cys 
        835                 840                 845             


Ser Tyr Asn Tyr Glu Gly Lys Gly Ser Leu Ala Gly Ser Val Gly Cys 
    850                 855                 860                 


Cys Ser Asp Arg Gln Glu Glu Glu Gly Leu Glu Phe Leu Asp His Leu 
865                 870                 875                 880 


Glu Pro Lys Phe Arg Thr Leu Ala Lys Thr Cys Ile Lys Lys 
                885                 890                 


<210>  5029
<211>  901
<212>  PRT
<213>  Homo sapiens

<400>  5029

Met Glu Ala Ala Arg Pro Ser Gly Ser Trp Asn Gly Ala Leu Cys Arg 
1               5                   10                  15      


Leu Leu Leu Leu Thr Leu Ala Ile Leu Ile Phe Ala Ser Asp Ala Cys 
            20                  25                  30          


Lys Asn Val Thr Leu His Val Pro Ser Lys Leu Asp Ala Glu Lys Leu 
        35                  40                  45              


Val Gly Arg Val Asn Leu Lys Glu Cys Phe Thr Ala Ala Asn Leu Ile 
    50                  55                  60                  


His Ser Ser Asp Pro Asp Phe Gln Ile Leu Glu Asp Gly Ser Val Tyr 
65                  70                  75                  80  


Thr Thr Asn Thr Ile Leu Leu Ser Ser Glu Lys Arg Ser Phe Thr Ile 
                85                  90                  95      


Leu Leu Ser Asn Thr Glu Asn Gln Glu Lys Lys Lys Ile Phe Val Phe 
            100                 105                 110         


Leu Glu His Gln Thr Lys Val Leu Lys Lys Arg His Thr Lys Glu Lys 
        115                 120                 125             


Val Leu Arg Arg Ala Lys Arg Arg Trp Ala Pro Ile Pro Cys Ser Met 
    130                 135                 140                 


Leu Glu Asn Ser Leu Gly Pro Phe Pro Leu Phe Leu Gln Gln Val Gln 
145                 150                 155                 160 


Ser Asp Thr Ala Gln Asn Tyr Thr Ile Tyr Tyr Ser Ile Arg Gly Pro 
                165                 170                 175     


Gly Val Asp Gln Glu Pro Arg Asn Leu Phe Tyr Val Glu Arg Asp Thr 
            180                 185                 190         


Gly Asn Leu Tyr Cys Thr Arg Pro Val Asp Arg Glu Gln Tyr Glu Ser 
        195                 200                 205             


Phe Glu Ile Ile Ala Phe Ala Thr Thr Pro Asp Gly Tyr Thr Pro Glu 
    210                 215                 220                 


Leu Pro Leu Pro Leu Ile Ile Lys Ile Glu Asp Glu Asn Asp Asn Tyr 
225                 230                 235                 240 


Pro Ile Phe Thr Glu Glu Thr Tyr Thr Phe Thr Ile Phe Glu Asn Cys 
                245                 250                 255     


Arg Val Gly Thr Thr Val Gly Gln Val Cys Ala Thr Asp Lys Asp Glu 
            260                 265                 270         


Pro Asp Thr Met His Thr Arg Leu Lys Tyr Ser Ile Ile Gly Gln Val 
        275                 280                 285             


Pro Pro Ser Pro Thr Leu Phe Ser Met His Pro Thr Thr Gly Val Ile 
    290                 295                 300                 


Thr Thr Thr Ser Ser Gln Leu Asp Arg Glu Leu Ile Asp Lys Tyr Gln 
305                 310                 315                 320 


Leu Lys Ile Lys Val Gln Asp Met Asp Gly Gln Tyr Phe Gly Leu Gln 
                325                 330                 335     


Thr Thr Ser Thr Cys Ile Ile Asn Ile Asp Asp Val Asn Asp His Leu 
            340                 345                 350         


Pro Thr Phe Thr Arg Thr Ser Tyr Val Thr Ser Val Glu Glu Asn Thr 
        355                 360                 365             


Val Asp Val Glu Ile Leu Arg Val Thr Val Glu Asp Lys Asp Leu Val 
    370                 375                 380                 


Asn Thr Ala Asn Trp Arg Ala Asn Tyr Thr Ile Leu Lys Gly Asn Glu 
385                 390                 395                 400 


Asn Gly Asn Phe Lys Ile Val Thr Asp Ala Lys Thr Asn Glu Gly Val 
                405                 410                 415     


Leu Cys Val Val Lys Pro Leu Asn Tyr Glu Glu Lys Gln Gln Met Ile 
            420                 425                 430         


Leu Gln Ile Gly Val Val Asn Glu Ala Pro Phe Ser Arg Glu Ala Ser 
        435                 440                 445             


Pro Arg Ser Ala Met Ser Thr Ala Thr Val Thr Val Asn Val Glu Asp 
    450                 455                 460                 


Gln Asp Glu Gly Pro Glu Cys Asn Pro Pro Ile Gln Thr Val Arg Met 
465                 470                 475                 480 


Lys Glu Asn Ala Glu Val Gly Thr Thr Ser Asn Gly Tyr Lys Ala Tyr 
                485                 490                 495     


Asp Pro Glu Thr Arg Ser Ser Ser Gly Ile Arg Tyr Lys Lys Leu Thr 
            500                 505                 510         


Asp Pro Thr Gly Trp Val Thr Ile Asp Glu Asn Thr Gly Ser Ile Lys 
        515                 520                 525             


Val Phe Arg Ser Leu Asp Arg Glu Ala Glu Thr Ile Lys Asn Gly Ile 
    530                 535                 540                 


Tyr Asn Ile Thr Val Leu Ala Ser Asp Gln Gly Gly Arg Thr Cys Thr 
545                 550                 555                 560 


Gly Thr Leu Gly Ile Ile Leu Gln Asp Val Asn Asp Asn Ser Pro Phe 
                565                 570                 575     


Ile Pro Lys Lys Thr Val Ile Ile Cys Lys Pro Thr Met Ser Ser Ala 
            580                 585                 590         


Glu Ile Val Ala Val Asp Pro Asp Glu Pro Ile His Gly Pro Pro Phe 
        595                 600                 605             


Asp Phe Ser Leu Glu Ser Ser Thr Ser Glu Val Gln Arg Met Trp Arg 
    610                 615                 620                 


Leu Lys Ala Ile Asn Asp Thr Ala Ala Arg Leu Ser Tyr Gln Asn Asp 
625                 630                 635                 640 


Pro Pro Phe Gly Ser Tyr Val Val Pro Ile Thr Val Arg Asp Arg Leu 
                645                 650                 655     


Gly Met Ser Ser Val Thr Ser Leu Asp Val Thr Leu Cys Asp Cys Ile 
            660                 665                 670         


Thr Glu Asn Asp Cys Thr His Arg Val Asp Pro Arg Ile Gly Gly Gly 
        675                 680                 685             


Gly Val Gln Leu Gly Lys Trp Ala Ile Leu Ala Ile Leu Leu Gly Ile 
    690                 695                 700                 


Ala Leu Leu Phe Cys Ile Leu Phe Thr Leu Val Cys Gly Ala Ser Gly 
705                 710                 715                 720 


Thr Ser Lys Gln Pro Lys Val Ile Pro Asp Asp Leu Ala Gln Gln Asn 
                725                 730                 735     


Leu Ile Val Ser Asn Thr Glu Ala Pro Gly Asp Asp Lys Val Tyr Ser 
            740                 745                 750         


Ala Asn Gly Phe Thr Thr Gln Thr Val Gly Ala Ser Ala Gln Gly Val 
        755                 760                 765             


Cys Gly Thr Val Gly Ser Gly Ile Lys Asn Gly Gly Gln Glu Thr Ile 
    770                 775                 780                 


Glu Met Val Lys Gly Gly His Gln Thr Ser Glu Ser Cys Arg Gly Ala 
785                 790                 795                 800 


Gly His His His Thr Leu Asp Ser Cys Arg Gly Gly His Thr Glu Val 
                805                 810                 815     


Asp Asn Cys Arg Tyr Thr Tyr Ser Glu Trp His Ser Phe Thr Gln Pro 
            820                 825                 830         


Arg Leu Gly Glu Lys Val Tyr Leu Cys Asn Gln Asp Glu Asn His Lys 
        835                 840                 845             


His Ala Gln Asp Tyr Val Leu Thr Tyr Asn Tyr Glu Gly Arg Gly Ser 
    850                 855                 860                 


Val Ala Gly Ser Val Gly Cys Cys Ser Glu Arg Gln Glu Glu Asp Gly 
865                 870                 875                 880 


Leu Glu Phe Leu Asp Asn Leu Glu Pro Lys Phe Arg Thr Leu Ala Glu 
                885                 890                 895     


Ala Cys Met Lys Arg 
            900     


<210>  5030
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  5030

Met Ala Ala Ala Gly Pro Arg Arg Ser Val Arg Gly Ala Val Cys Leu 
1               5                   10                  15      


His Leu Leu Leu Thr Leu Val Ile Phe Ser Arg Ala Gly Glu Ala Cys 
            20                  25                  30          


Lys Lys Val Ile Leu Asn Val Pro Ser Lys Leu Glu Ala Asp Lys Ile 
        35                  40                  45              


Ile Gly Arg Val Asn Leu Glu Glu Cys Phe Arg Ser Ala Asp Leu Ile 
    50                  55                  60                  


Arg Ser Ser Asp Pro Asp Phe Arg Val Leu Asn Asp Gly Ser Val Tyr 
65                  70                  75                  80  


Thr Ala Arg Ala Val Ala Leu Ser Asp Lys Lys Arg Ser Phe Thr Ile 
                85                  90                  95      


Trp Leu Ser Asp Lys Arg Lys Gln Thr Gln Lys Glu Val Thr Val Leu 
            100                 105                 110         


Leu Glu His Gln Lys Lys Val Ser Lys Thr Arg His Thr Arg Glu Thr 
        115                 120                 125             


Val Leu Arg Arg Ala Lys Arg Arg Trp Ala Pro Ile Pro Cys Ser Met 
    130                 135                 140                 


Gln Glu Asn Ser Leu Gly Pro Phe Pro Leu Phe Leu Gln Gln Val Glu 
145                 150                 155                 160 


Ser Asp Ala Ala Gln Asn Tyr Thr Val Phe Tyr Ser Ile Ser Gly Arg 
                165                 170                 175     


Gly Val Asp Lys Glu Pro Leu Asn Leu Phe Tyr Ile Glu Arg Asp Thr 
            180                 185                 190         


Gly Asn Leu Phe Cys Thr Arg Pro Val Asp Arg Glu Glu Tyr Asp Val 
        195                 200                 205             


Phe Asp Leu Ile Ala Tyr Ala Ser Thr Ala Asp Gly Tyr Ser Ala Asp 
    210                 215                 220                 


Leu Pro Leu Pro Leu Pro Ile Arg Val Glu Asp Glu Asn Asp Asn His 
225                 230                 235                 240 


Pro Val Phe Thr Glu Ala Ile Tyr Asn Phe Glu Val Leu Glu Ser Ser 
                245                 250                 255     


Arg Pro Gly Thr Thr Val Gly Val Val Cys Ala Thr Asp Arg Asp Glu 
            260                 265                 270         


Pro Asp Thr Met His Thr Arg Leu Lys Tyr Ser Ile Leu Gln Gln Thr 
        275                 280                 285             


Pro Arg Ser Pro Gly Leu Phe Ser Val His Pro Ser Thr Gly Val Ile 
    290                 295                 300                 


Thr Thr Val Ser His Tyr Leu Asp Arg Glu Val Val Asp Lys Tyr Ser 
305                 310                 315                 320 


Leu Ile Met Lys Val Gln Asp Met Asp Gly Gln Phe Phe Gly Leu Ile 
                325                 330                 335     


Gly Thr Ser Thr Cys Ile Ile Thr Val Thr Asp Ser Asn Asp Asn Ala 
            340                 345                 350         


Pro Thr Phe Arg Gln Asn Ala Tyr Glu Ala Phe Val Glu Glu Asn Ala 
        355                 360                 365             


Phe Asn Val Glu Ile Leu Arg Ile Pro Ile Glu Asp Lys Asp Leu Ile 
    370                 375                 380                 


Asn Thr Ala Asn Trp Arg Val Asn Phe Thr Ile Leu Lys Gly Asn Glu 
385                 390                 395                 400 


Asn Gly His Phe Lys Ile Ser Thr Asp Lys Glu Thr Asn Glu Gly Val 
                405                 410                 415     


Leu Ser Val Val Lys Pro Leu Asn Tyr Glu Glu Asn Arg Gln Val Asn 
            420                 425                 430         


Leu Glu Ile Gly Val Asn Asn Glu Ala Pro Phe Ala Arg Asp Ile Pro 
        435                 440                 445             


Arg Val Thr Ala Leu Asn Arg Ala Leu Val Thr Val His Val Arg Asp 
    450                 455                 460                 


Leu Asp Glu Gly Pro Glu Cys Thr Pro Ala Ala Gln Tyr Val Arg Ile 
465                 470                 475                 480 


Lys Glu Asn Leu Ala Val Gly Ser Lys Ile Asn Gly Tyr Lys Ala Tyr 
                485                 490                 495     


Asp Pro Glu Asn Arg Asn Gly Asn Gly Leu Arg Tyr Lys Lys Leu His 
            500                 505                 510         


Asp Pro Lys Gly Trp Ile Thr Ile Asp Glu Ile Ser Gly Ser Ile Ile 
        515                 520                 525             


Thr Ser Lys Ile Leu Asp Arg Glu Val Glu Thr Pro Lys Asn Glu Leu 
    530                 535                 540                 


Tyr Asn Ile Thr Val Leu Ala Ile Asp Lys Asp Asp Arg Ser Cys Thr 
545                 550                 555                 560 


Gly Thr Leu Ala Val Asn Ile Glu Asp Val Asn Asp Asn Pro Pro Glu 
                565                 570                 575     


Ile Leu Gln Glu Tyr Val Val Ile Cys Lys Pro Lys Met Gly Tyr Thr 
            580                 585                 590         


Asp Ile Leu Ala Val Asp Pro Asp Glu Pro Val His Gly Ala Pro Phe 
        595                 600                 605             


Tyr Phe Ser Leu Pro Asn Thr Ser Pro Glu Ile Ser Arg Leu Trp Ser 
    610                 615                 620                 


Leu Thr Lys Val Asn Asp Thr Ala Ala Arg Leu Ser Tyr Gln Lys Asn 
625                 630                 635                 640 


Ala Gly Phe Gln Glu Tyr Thr Ile Pro Ile Thr Val Lys Asp Arg Ala 
                645                 650                 655     


Gly Gln Ala Ala Thr Lys Leu Leu Arg Val Asn Leu Cys Glu Cys Thr 
            660                 665                 670         


His Pro Thr Gln Cys Arg Ala Thr Ser Arg Ser Thr Gly Val Ile Leu 
        675                 680                 685             


Gly Lys Trp Ala Ile Leu Ala Ile Leu Leu Gly Ile Ala Leu Leu Phe 
    690                 695                 700                 


Ser Val Leu Leu Thr Leu Val Cys Gly Val Phe Gly Ala Thr Lys Gly 
705                 710                 715                 720 


Lys Arg Phe Pro Glu Asp Leu Ala Gln Gln Asn Leu Ile Ile Ser Asn 
                725                 730                 735     


Thr Glu Ala Pro Gly Asp Asp Arg Val Cys Ser Ala Asn Gly Phe Met 
            740                 745                 750         


Thr Gln Thr Thr Asn Asn Ser Ser Gln Gly Phe Cys Gly Thr Met Gly 
        755                 760                 765             


Ser Gly Met Lys Asn Gly Gly Gln Glu Thr Ile Glu Met Met Lys Gly 
    770                 775                 780                 


Gly Asn Gln Thr Leu Glu Ser Cys Arg Gly Ala Gly His His His Thr 
785                 790                 795                 800 


Leu Asp Ser Cys Arg Gly Gly His Thr Glu Val Asp Asn Cys Arg Tyr 
                805                 810                 815     


Thr Tyr Ser Glu Trp His Ser Phe Thr Gln Pro Arg Leu Gly Glu Glu 
            820                 825                 830         


Ser Ile Arg Gly His Thr Gly 
        835                 


<210>  5031
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  5031

Met Gln Asp Pro Ala Ser Thr Cys Val Pro Glu Pro Ala Ser Gln His 
1               5                   10                  15      


Thr Leu Arg Ser Gly Pro Gly Cys Leu Gln Gln Pro Glu Gln Gln Gly 
            20                  25                  30          


Val Arg Asp Pro Gly Gly Ile Trp Ala Lys Leu Gly Ala Ala Glu Ala 
        35                  40                  45              


Ser Ala Glu Arg Leu Gln Gly Arg Arg Ser Arg Gly Ala Ser Gly Ser 
    50                  55                  60                  


Glu Pro Gln Gln Met Gly Ser Asp Val Arg Asp Leu Asn Ala Leu Leu 
65                  70                  75                  80  


Pro Ala Val Pro Ser Leu Gly Gly Gly Gly Gly Cys Ala Leu Pro Val 
                85                  90                  95      


Ser Gly Ala Ala Gln Trp Ala Pro Val Leu Asp Phe Ala Pro Pro Gly 
            100                 105                 110         


Ala Ser Ala Tyr Gly Ser Leu Gly Gly Pro Ala Pro Pro Pro Ala Pro 
        115                 120                 125             


Pro Pro Pro Pro Pro Pro Pro Pro His Ser Phe Ile Lys Gln Glu Pro 
    130                 135                 140                 


Ser Trp Gly Gly Ala Glu Pro His Glu Glu Gln Cys Leu Ser Ala Phe 
145                 150                 155                 160 


Thr Val His Phe Ser Gly Gln Phe Thr Gly Thr Ala Gly Ala Cys Arg 
                165                 170                 175     


Tyr Gly Pro Phe Gly Pro Pro Pro Pro Ser Gln Ala Ser Ser Gly Gln 
            180                 185                 190         


Ala Arg Met Phe Pro Asn Ala Pro Tyr Leu Pro Ser Cys Leu Glu Ser 
        195                 200                 205             


Gln Pro Ala Ile Arg Asn Gln Gly Tyr Ser Thr Val Thr Phe Asp Gly 
    210                 215                 220                 


Thr Pro Ser Tyr Gly His Thr Pro Ser His His Ala Ala Gln Phe Pro 
225                 230                 235                 240 


Asn His Ser Phe Lys His Glu Asp Pro Met Gly Gln Gln Gly Ser Leu 
                245                 250                 255     


Gly Glu Gln Gln Tyr Ser Val Pro Pro Pro Val Tyr Gly Cys His Thr 
            260                 265                 270         


Pro Thr Asp Ser Cys Thr Gly Ser Gln Ala Leu Leu Leu Arg Thr Pro 
        275                 280                 285             


Tyr Ser Ser Asp Asn Leu Tyr Gln Met Thr Ser Gln Leu Glu Cys Met 
    290                 295                 300                 


Thr Trp Asn Gln Met Asn Leu Gly Ala Thr Leu Lys Gly Val Ala Ala 
305                 310                 315                 320 


Gly Ser Ser Ser Ser Val Lys Trp Thr Glu Gly Gln Ser Asn His Ser 
                325                 330                 335     


Thr Gly Tyr Glu Ser Asp Asn His Thr Thr Pro Ile Leu Cys Gly Ala 
            340                 345                 350         


Gln Tyr Arg Ile His Thr His Gly Val Phe Arg Gly Ile Gln Asp Val 
        355                 360                 365             


Arg Arg Val Pro Gly Val Ala Pro Thr Leu Val Arg Ser Ala Ser Glu 
    370                 375                 380                 


Thr Ser Glu Lys Arg Pro Phe Met Cys Ala Tyr Pro Gly Cys Asn Lys 
385                 390                 395                 400 


Arg Tyr Phe Lys Leu Ser His Leu Gln Met His Ser Arg Lys His Thr 
                405                 410                 415     


Gly Glu Lys Pro Tyr Gln Cys Asp Phe Lys Asp Cys Glu Arg Arg Phe 
            420                 425                 430         


Ser Arg Ser Asp Gln Leu Lys Arg His Gln Arg Arg His Thr Gly Val 
        435                 440                 445             


Lys Pro Phe Gln Cys Lys Thr Cys Gln Arg Lys Phe Ser Arg Ser Asp 
    450                 455                 460                 


His Leu Lys Thr His Thr Arg Thr His Thr Gly Glu Lys Pro Phe Ser 
465                 470                 475                 480 


Cys Arg Trp Pro Ser Cys Gln Lys Lys Phe Ala Arg Ser Asp Glu Leu 
                485                 490                 495     


Val Arg His His Asn Met His Gln Arg Asn Met Thr Lys Leu Gln Leu 
            500                 505                 510         


Ala Leu 
        


<210>  5032
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  5032

Met Gln Asp Pro Ala Ser Thr Cys Val Pro Glu Pro Ala Ser Gln His 
1               5                   10                  15      


Thr Leu Arg Ser Gly Pro Gly Cys Leu Gln Gln Pro Glu Gln Gln Gly 
            20                  25                  30          


Val Arg Asp Pro Gly Gly Ile Trp Ala Lys Leu Gly Ala Ala Glu Ala 
        35                  40                  45              


Ser Ala Glu Arg Leu Gln Gly Arg Arg Ser Arg Gly Ala Ser Gly Ser 
    50                  55                  60                  


Glu Pro Gln Gln Met Gly Ser Asp Val Arg Asp Leu Asn Ala Leu Leu 
65                  70                  75                  80  


Pro Ala Val Pro Ser Leu Gly Gly Gly Gly Gly Cys Ala Leu Pro Val 
                85                  90                  95      


Ser Gly Ala Ala Gln Trp Ala Pro Val Leu Asp Phe Ala Pro Pro Gly 
            100                 105                 110         


Ala Ser Ala Tyr Gly Ser Leu Gly Gly Pro Ala Pro Pro Pro Ala Pro 
        115                 120                 125             


Pro Pro Pro Pro Pro Pro Pro Pro His Ser Phe Ile Lys Gln Glu Pro 
    130                 135                 140                 


Ser Trp Gly Gly Ala Glu Pro His Glu Glu Gln Cys Leu Ser Ala Phe 
145                 150                 155                 160 


Thr Val His Phe Ser Gly Gln Phe Thr Gly Thr Ala Gly Ala Cys Arg 
                165                 170                 175     


Tyr Gly Pro Phe Gly Pro Pro Pro Pro Ser Gln Ala Ser Ser Gly Gln 
            180                 185                 190         


Ala Arg Met Phe Pro Asn Ala Pro Tyr Leu Pro Ser Cys Leu Glu Ser 
        195                 200                 205             


Gln Pro Ala Ile Arg Asn Gln Gly Tyr Ser Thr Val Thr Phe Asp Gly 
    210                 215                 220                 


Thr Pro Ser Tyr Gly His Thr Pro Ser His His Ala Ala Gln Phe Pro 
225                 230                 235                 240 


Asn His Ser Phe Lys His Glu Asp Pro Met Gly Gln Gln Gly Ser Leu 
                245                 250                 255     


Gly Glu Gln Gln Tyr Ser Val Pro Pro Pro Val Tyr Gly Cys His Thr 
            260                 265                 270         


Pro Thr Asp Ser Cys Thr Gly Ser Gln Ala Leu Leu Leu Arg Thr Pro 
        275                 280                 285             


Tyr Ser Ser Asp Asn Leu Tyr Gln Met Thr Ser Gln Leu Glu Cys Met 
    290                 295                 300                 


Thr Trp Asn Gln Met Asn Leu Gly Ala Thr Leu Lys Gly Val Ala Ala 
305                 310                 315                 320 


Gly Ser Ser Ser Ser Val Lys Trp Thr Glu Gly Gln Ser Asn His Ser 
                325                 330                 335     


Thr Gly Tyr Glu Ser Asp Asn His Thr Thr Pro Ile Leu Cys Gly Ala 
            340                 345                 350         


Gln Tyr Arg Ile His Thr His Gly Val Phe Arg Gly Ile Gln Asp Val 
        355                 360                 365             


Arg Arg Val Pro Gly Val Ala Pro Thr Leu Val Arg Ser Ala Ser Glu 
    370                 375                 380                 


Thr Ser Glu Lys Arg Pro Phe Met Cys Ala Tyr Pro Gly Cys Asn Lys 
385                 390                 395                 400 


Arg Tyr Phe Lys Leu Ser His Leu Gln Met His Ser Arg Lys His Thr 
                405                 410                 415     


Gly Glu Lys Pro Tyr Gln Cys Asp Phe Lys Asp Cys Glu Arg Arg Phe 
            420                 425                 430         


Ser Arg Ser Asp Gln Leu Lys Arg His Gln Arg Arg His Thr Gly Val 
        435                 440                 445             


Lys Pro Phe Gln Cys Lys Thr Cys Gln Arg Lys Phe Ser Arg Ser Asp 
    450                 455                 460                 


His Leu Lys Thr His Thr Arg Thr His Thr Gly Lys Thr Ser Glu Lys 
465                 470                 475                 480 


Pro Phe Ser Cys Arg Trp Pro Ser Cys Gln Lys Lys Phe Ala Arg Ser 
                485                 490                 495     


Asp Glu Leu Val Arg His His Asn Met His Gln Arg Asn Met Thr Lys 
            500                 505                 510         


Leu Gln Leu Ala Leu 
        515         


<210>  5033
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  5033

Met Gln Asp Pro Ala Ser Thr Cys Val Pro Glu Pro Ala Ser Gln His 
1               5                   10                  15      


Thr Leu Arg Ser Gly Pro Gly Cys Leu Gln Gln Pro Glu Gln Gln Gly 
            20                  25                  30          


Val Arg Asp Pro Gly Gly Ile Trp Ala Lys Leu Gly Ala Ala Glu Ala 
        35                  40                  45              


Ser Ala Glu Arg Leu Gln Gly Arg Arg Ser Arg Gly Ala Ser Gly Ser 
    50                  55                  60                  


Glu Pro Gln Gln Met Gly Ser Asp Val Arg Asp Leu Asn Ala Leu Leu 
65                  70                  75                  80  


Pro Ala Val Pro Ser Leu Gly Gly Gly Gly Gly Cys Ala Leu Pro Val 
                85                  90                  95      


Ser Gly Ala Ala Gln Trp Ala Pro Val Leu Asp Phe Ala Pro Pro Gly 
            100                 105                 110         


Ala Ser Ala Tyr Gly Ser Leu Gly Gly Pro Ala Pro Pro Pro Ala Pro 
        115                 120                 125             


Pro Pro Pro Pro Pro Pro Pro Pro His Ser Phe Ile Lys Gln Glu Pro 
    130                 135                 140                 


Ser Trp Gly Gly Ala Glu Pro His Glu Glu Gln Cys Leu Ser Ala Phe 
145                 150                 155                 160 


Thr Val His Phe Ser Gly Gln Phe Thr Gly Thr Ala Gly Ala Cys Arg 
                165                 170                 175     


Tyr Gly Pro Phe Gly Pro Pro Pro Pro Ser Gln Ala Ser Ser Gly Gln 
            180                 185                 190         


Ala Arg Met Phe Pro Asn Ala Pro Tyr Leu Pro Ser Cys Leu Glu Ser 
        195                 200                 205             


Gln Pro Ala Ile Arg Asn Gln Gly Tyr Ser Thr Val Thr Phe Asp Gly 
    210                 215                 220                 


Thr Pro Ser Tyr Gly His Thr Pro Ser His His Ala Ala Gln Phe Pro 
225                 230                 235                 240 


Asn His Ser Phe Lys His Glu Asp Pro Met Gly Gln Gln Gly Ser Leu 
                245                 250                 255     


Gly Glu Gln Gln Tyr Ser Val Pro Pro Pro Val Tyr Gly Cys His Thr 
            260                 265                 270         


Pro Thr Asp Ser Cys Thr Gly Ser Gln Ala Leu Leu Leu Arg Thr Pro 
        275                 280                 285             


Tyr Ser Ser Asp Asn Leu Tyr Gln Met Thr Ser Gln Leu Glu Cys Met 
    290                 295                 300                 


Thr Trp Asn Gln Met Asn Leu Gly Ala Thr Leu Lys Gly Val Ala Ala 
305                 310                 315                 320 


Gly Ser Ser Ser Ser Val Lys Trp Thr Glu Gly Gln Ser Asn His Ser 
                325                 330                 335     


Thr Gly Tyr Glu Ser Asp Asn His Thr Thr Pro Ile Leu Cys Gly Ala 
            340                 345                 350         


Gln Tyr Arg Ile His Thr His Gly Val Phe Arg Gly Ile Gln Asp Val 
        355                 360                 365             


Arg Arg Val Pro Gly Val Ala Pro Thr Leu Val Arg Ser Ala Ser Glu 
    370                 375                 380                 


Thr Ser Glu Lys Arg Pro Phe Met Cys Ala Tyr Pro Gly Cys Asn Lys 
385                 390                 395                 400 


Arg Tyr Phe Lys Leu Ser His Leu Gln Met His Ser Arg Lys His Thr 
                405                 410                 415     


Gly Glu Lys Pro Tyr Gln Cys Asp Phe Lys Asp Cys Glu Arg Arg Phe 
            420                 425                 430         


Ser Arg Ser Asp Gln Leu Lys Arg His Gln Arg Arg His Thr Gly Val 
        435                 440                 445             


Lys Pro Phe Gln Cys Lys Thr Cys Gln Arg Lys Phe Ser Arg Ser Asp 
    450                 455                 460                 


His Leu Lys Thr His Thr Arg Thr His Thr Gly Lys Thr Ser Glu Lys 
465                 470                 475                 480 


Pro Phe Ser Cys Arg Trp Pro Ser Cys Gln Lys Lys Phe Ala Arg Ser 
                485                 490                 495     


Asp Glu Leu Val Arg His His Asn Met His Gln Arg Asn Met Thr Lys 
            500                 505                 510         


Leu Gln Leu Ala Leu 
        515         


<210>  5034
<211>  1499
<212>  PRT
<213>  Homo sapiens

<400>  5034

Met Glu Arg Glu Pro Ala Gly Thr Glu Glu Pro Gly Pro Pro Gly Arg 
1               5                   10                  15      


Arg Arg Arg Arg Glu Gly Arg Thr Arg Thr Val Arg Ser Asn Leu Leu 
            20                  25                  30          


Pro Pro Pro Gly Ala Glu Asp Pro Ala Ala Gly Ala Ala Lys Gly Glu 
        35                  40                  45              


Arg Arg Arg Arg Arg Gly Cys Ala Gln His Leu Ala Asp Asn Arg Leu 
    50                  55                  60                  


Lys Thr Thr Lys Tyr Thr Leu Leu Ser Phe Leu Pro Lys Asn Leu Phe 
65                  70                  75                  80  


Glu Gln Phe His Arg Pro Ala Asn Val Tyr Phe Val Phe Ile Ala Leu 
                85                  90                  95      


Leu Asn Phe Val Pro Ala Val Asn Ala Phe Gln Pro Gly Leu Ala Leu 
            100                 105                 110         


Ala Pro Val Leu Phe Ile Leu Ala Ile Thr Ala Phe Arg Asp Leu Trp 
        115                 120                 125             


Glu Asp Tyr Ser Arg His Arg Ser Asp His Lys Ile Asn His Leu Gly 
    130                 135                 140                 


Cys Leu Val Phe Ser Arg Glu Glu Lys Lys Tyr Val Asn Arg Phe Trp 
145                 150                 155                 160 


Lys Glu Ile His Val Gly Asp Phe Val Arg Leu Arg Cys Asn Glu Ile 
                165                 170                 175     


Phe Pro Ala Asp Ile Leu Leu Leu Ser Ser Ser Asp Pro Asp Gly Leu 
            180                 185                 190         


Cys His Ile Glu Thr Ala Asn Leu Asp Gly Glu Thr Asn Leu Lys Arg 
        195                 200                 205             


Arg Gln Val Val Arg Gly Phe Ser Glu Leu Val Ser Glu Phe Asn Pro 
    210                 215                 220                 


Leu Thr Phe Thr Ser Val Ile Glu Cys Glu Lys Pro Asn Asn Asp Leu 
225                 230                 235                 240 


Ser Arg Phe Arg Gly Cys Ile Ile His Asp Asn Gly Lys Lys Ala Gly 
                245                 250                 255     


Leu Tyr Lys Glu Asn Leu Leu Leu Arg Gly Cys Thr Leu Arg Asn Thr 
            260                 265                 270         


Asp Ala Val Val Gly Ile Val Ile Tyr Ala Gly His Glu Thr Lys Ala 
        275                 280                 285             


Leu Leu Asn Asn Ser Gly Pro Arg Tyr Lys Arg Ser Lys Leu Glu Arg 
    290                 295                 300                 


Gln Met Asn Cys Asp Val Leu Trp Cys Val Leu Leu Leu Val Cys Met 
305                 310                 315                 320 


Ser Leu Phe Ser Ala Val Gly His Gly Leu Trp Ile Trp Arg Tyr Gln 
                325                 330                 335     


Glu Lys Lys Ser Leu Phe Tyr Val Pro Lys Ser Asp Gly Ser Ser Leu 
            340                 345                 350         


Ser Pro Val Thr Ala Ala Val Tyr Ser Phe Leu Thr Met Ile Ile Val 
        355                 360                 365             


Leu Gln Val Leu Ile Pro Ile Ser Leu Tyr Val Ser Ile Glu Ile Val 
    370                 375                 380                 


Lys Ala Cys Gln Val Tyr Phe Ile Asn Gln Asp Met Gln Leu Tyr Asp 
385                 390                 395                 400 


Glu Glu Thr Asp Ser Gln Leu Gln Cys Arg Ala Leu Asn Ile Thr Glu 
                405                 410                 415     


Asp Leu Gly Gln Ile Gln Tyr Ile Phe Ser Asp Lys Thr Gly Thr Leu 
            420                 425                 430         


Thr Glu Asn Lys Met Val Phe Arg Arg Cys Thr Val Ser Gly Val Glu 
        435                 440                 445             


Tyr Ser His Asp Ala Asn Ala Gln Arg Leu Ala Arg Tyr Gln Glu Ala 
    450                 455                 460                 


Asp Ser Glu Glu Glu Glu Val Val Pro Arg Gly Gly Ser Val Ser Gln 
465                 470                 475                 480 


Arg Gly Ser Ile Gly Ser His Gln Ser Val Arg Val Val His Arg Thr 
                485                 490                 495     


Gln Ser Thr Lys Ser His Arg Arg Thr Gly Ser Arg Ala Glu Ala Lys 
            500                 505                 510         


Arg Ala Ser Met Leu Ser Lys His Thr Ala Phe Ser Ser Pro Met Glu 
        515                 520                 525             


Lys Asp Ile Thr Pro Asp Pro Lys Leu Leu Glu Lys Val Ser Glu Cys 
    530                 535                 540                 


Asp Lys Ser Leu Ala Val Ala Arg His Gln Glu His Leu Leu Ala His 
545                 550                 555                 560 


Leu Ser Pro Glu Leu Ser Asp Val Phe Asp Phe Phe Ile Ala Leu Thr 
                565                 570                 575     


Ile Cys Asn Thr Val Val Val Thr Ser Pro Asp Gln Pro Arg Thr Lys 
            580                 585                 590         


Val Arg Val Arg Phe Glu Leu Lys Ser Pro Val Lys Thr Ile Glu Asp 
        595                 600                 605             


Phe Leu Arg Arg Phe Thr Pro Ser Cys Leu Thr Ser Gly Cys Ser Ser 
    610                 615                 620                 


Ile Gly Ser Leu Ala Ala Asn Lys Ser Ser His Lys Leu Gly Ser Ser 
625                 630                 635                 640 


Phe Pro Ser Thr Pro Ser Ser Asp Gly Met Leu Leu Arg Leu Glu Glu 
                645                 650                 655     


Arg Leu Gly Gln Pro Thr Ser Ala Ile Ala Ser Asn Gly Tyr Ser Ser 
            660                 665                 670         


Gln Ala Asp Asn Trp Ala Ser Glu Leu Ala Gln Glu Gln Glu Ser Glu 
        675                 680                 685             


Arg Glu Leu Arg Tyr Glu Ala Glu Ser Pro Asp Glu Ala Ala Leu Val 
    690                 695                 700                 


Tyr Ala Ala Arg Ala Tyr Asn Cys Val Leu Val Glu Arg Leu His Asp 
705                 710                 715                 720 


Gln Val Ser Val Glu Leu Pro His Leu Gly Arg Leu Thr Phe Glu Leu 
                725                 730                 735     


Leu His Thr Leu Gly Phe Asp Ser Val Arg Lys Arg Met Ser Val Val 
            740                 745                 750         


Ile Arg His Pro Leu Thr Asp Glu Ile Asn Val Tyr Thr Lys Gly Ala 
        755                 760                 765             


Asp Ser Val Val Met Asp Leu Leu Gln Pro Cys Ser Ser Val Asp Ala 
    770                 775                 780                 


Arg Gly Arg His Gln Lys Lys Ile Arg Ser Lys Thr Gln Asn Tyr Leu 
785                 790                 795                 800 


Asn Val Tyr Ala Ala Glu Gly Leu Arg Thr Leu Cys Ile Ala Lys Arg 
                805                 810                 815     


Val Leu Ser Lys Glu Glu Tyr Ala Cys Trp Leu Gln Ser His Leu Glu 
            820                 825                 830         


Ala Glu Ser Ser Leu Glu Asn Ser Glu Glu Leu Leu Phe Gln Ser Ala 
        835                 840                 845             


Ile Arg Leu Glu Thr Asn Leu His Leu Leu Gly Ala Thr Gly Ile Glu 
    850                 855                 860                 


Asp Arg Leu Gln Asp Gly Val Pro Glu Thr Ile Ser Lys Leu Arg Gln 
865                 870                 875                 880 


Ala Gly Leu Gln Ile Trp Val Leu Thr Gly Asp Lys Gln Glu Thr Ala 
                885                 890                 895     


Val Asn Ile Ala Tyr Ala Cys Lys Leu Leu Asp His Asp Glu Glu Val 
            900                 905                 910         


Ile Thr Leu Asn Ala Thr Ser Gln Glu Ala Cys Ala Ala Leu Leu Asp 
        915                 920                 925             


Gln Cys Leu Cys Tyr Val Gln Ser Arg Gly Leu Gln Arg Ala Pro Glu 
    930                 935                 940                 


Lys Thr Lys Gly Lys Val Ser Met Arg Phe Ser Ser Leu Cys Pro Pro 
945                 950                 955                 960 


Ser Thr Ser Thr Ala Ser Gly Arg Arg Pro Ser Leu Val Ile Asp Gly 
                965                 970                 975     


Arg Ser Leu Ala Tyr Ala Leu Glu Lys Asn Leu Glu Asp Lys Phe Leu 
            980                 985                 990         


Phe Leu Ala Lys Gln Cys Arg Ser  Val Leu Cys Cys Arg  Ser Thr Pro 
        995                 1000                 1005             


Leu Gln  Lys Ser Met Val Val  Lys Leu Val Arg Ser  Lys Leu Lys 
    1010                 1015                 1020             


Ala Met  Thr Leu Ala Ile Gly  Asp Gly Ala Asn Asp  Val Ser Met 
    1025                 1030                 1035             


Ile Gln  Val Ala Asp Val Gly  Val Gly Ile Ser Gly  Gln Glu Gly 
    1040                 1045                 1050             


Met Gln  Ala Val Met Ala Ser  Asp Phe Ala Val Pro  Lys Phe Arg 
    1055                 1060                 1065             


Tyr Leu  Glu Arg Leu Leu Ile  Leu His Gly His Trp  Cys Tyr Ser 
    1070                 1075                 1080             


Arg Leu  Ala Asn Met Val Leu  Tyr Phe Phe Tyr Lys  Asn Thr Met 
    1085                 1090                 1095             


Phe Val  Gly Leu Leu Phe Trp  Phe Gln Phe Phe Cys  Gly Phe Ser 
    1100                 1105                 1110             


Ala Ser  Thr Met Ile Asp Gln  Trp Tyr Leu Ile Phe  Phe Asn Leu 
    1115                 1120                 1125             


Leu Phe  Ser Ser Leu Pro Pro  Leu Val Thr Gly Val  Leu Asp Arg 
    1130                 1135                 1140             


Asp Val  Pro Ala Asn Val Leu  Leu Thr Asn Pro Gln  Leu Tyr Lys 
    1145                 1150                 1155             


Ser Gly  Gln Asn Met Glu Glu  Tyr Arg Pro Arg Thr  Phe Trp Phe 
    1160                 1165                 1170             


Asn Met  Ala Asp Ala Ala Phe  Gln Ser Leu Val Cys  Phe Ser Ile 
    1175                 1180                 1185             


Pro Tyr  Leu Ala Tyr Tyr Asp  Ser Asn Val Asp Leu  Phe Thr Trp 
    1190                 1195                 1200             


Gly Thr  Pro Ile Val Thr Ile  Ala Leu Leu Thr Phe  Leu Leu His 
    1205                 1210                 1215             


Leu Gly  Ile Glu Thr Lys Thr  Trp Thr Trp Leu Asn  Trp Ile Thr 
    1220                 1225                 1230             


Cys Gly  Phe Ser Val Leu Leu  Phe Phe Thr Val Ala  Leu Ile Tyr 
    1235                 1240                 1245             


Asn Ala  Ser Cys Ala Thr Cys  Tyr Pro Pro Ser Asn  Pro Tyr Trp 
    1250                 1255                 1260             


Thr Met  Gln Ala Leu Leu Gly  Asp Pro Val Phe Tyr  Leu Thr Cys 
    1265                 1270                 1275             


Leu Met  Thr Pro Val Ala Ala  Leu Leu Pro Arg Leu  Phe Phe Arg 
    1280                 1285                 1290             


Ser Leu  Gln Gly Arg Val Phe  Pro Thr Gln Leu Gln  Leu Ala Arg 
    1295                 1300                 1305             


Gln Leu  Thr Arg Lys Ser Pro  Arg Arg Cys Ser Ala  Pro Lys Glu 
    1310                 1315                 1320             


Thr Phe  Ala Gln Gly Arg Leu  Pro Lys Asp Ser Gly  Thr Glu His 
    1325                 1330                 1335             


Ser Ser  Gly Arg Thr Val Lys  Thr Ser Val Pro Leu  Ser Gln Pro 
    1340                 1345                 1350             


Ser Trp  His Thr Gln Gln Pro  Val Cys Ser Leu Glu  Ala Ser Gly 
    1355                 1360                 1365             


Glu Pro  Ser Thr Val Asp Met  Ser Met Pro Val Arg  Glu His Thr 
    1370                 1375                 1380             


Leu Leu  Glu Gly Leu Ser Ala  Pro Ala Pro Met Ser  Ser Ala Pro 
    1385                 1390                 1395             


Gly Glu  Ala Val Leu Arg Ser  Pro Gly Gly Cys Pro  Glu Glu Ser 
    1400                 1405                 1410             


Lys Val  Arg Ala Ala Ser Thr  Gly Arg Val Thr Pro  Leu Ser Ser 
    1415                 1420                 1425             


Leu Phe  Ser Leu Pro Thr Phe  Ser Leu Leu Asn Trp  Ile Ser Ser 
    1430                 1435                 1440             


Trp Ser  Leu Val Ser Arg Leu  Gly Ser Val Leu Gln  Phe Ser Arg 
    1445                 1450                 1455             


Thr Glu  Gln Leu Ala Asp Gly  Gln Ala Gly Arg Gly  Leu Pro Val 
    1460                 1465                 1470             


Gln Pro  His Ser Gly Arg Ser  Gly Leu Gln Gly Pro  Asp His Arg 
    1475                 1480                 1485             


Leu Leu  Ile Gly Ala Ser Ser  Arg Arg Ser Gln 
    1490                 1495                 


<210>  5035
<211>  765
<212>  PRT
<213>  Homo sapiens

<400>  5035

Met Asn Thr Ser Gly Asp Pro Ala Gln Thr Gly Pro Glu Gly Cys Arg 
1               5                   10                  15      


Gly Thr Met Ser Ala Glu Glu Asp Ala Arg Trp Leu Arg Trp Val Thr 
            20                  25                  30          


Gln Gln Phe Lys Thr Ile Ala Gly Glu Asp Gly Glu Ile Ser Leu Gln 
        35                  40                  45              


Glu Phe Lys Ala Ala Leu His Val Lys Glu Ser Phe Phe Ala Glu Arg 
    50                  55                  60                  


Phe Phe Ala Leu Phe Asp Ser Asp Arg Ser Gly Thr Ile Thr Leu Gln 
65                  70                  75                  80  


Glu Leu Gln Glu Ala Leu Thr Leu Leu Ile His Gly Ser Pro Met Asp 
                85                  90                  95      


Lys Leu Lys Phe Leu Phe Gln Val Tyr Asp Ile Asp Val Cys Ala Arg 
            100                 105                 110         


Gln Gly Ala Ser Ala Gly Thr Glu Trp Gly Ala Gly Ala Gly Pro His 
        115                 120                 125             


Trp Ala Ser Ser Pro Leu Gly Thr Gly Ser Gly Ser Ile Asp Pro Asp 
    130                 135                 140                 


Glu Leu Arg Thr Val Leu Gln Ser Cys Leu Arg Glu Ser Ala Ile Ser 
145                 150                 155                 160 


Leu Pro Asp Glu Lys Leu Asp Gln Leu Thr Leu Ala Leu Phe Glu Ser 
                165                 170                 175     


Ala Asp Ala Asp Gly Asn Gly Ala Ile Thr Phe Glu Glu Leu Arg Asp 
            180                 185                 190         


Glu Leu Gln Arg Phe Pro Gly Val Met Glu Asn Leu Thr Ile Ser Ala 
        195                 200                 205             


Ala His Trp Leu Thr Ala Pro Ala Pro Arg Pro Arg Pro Arg Arg Pro 
    210                 215                 220                 


Arg Gln Leu Thr Arg Ala Tyr Trp His Asn His Arg Ser Gln Leu Phe 
225                 230                 235                 240 


Cys Leu Ala Thr Tyr Ala Gly Leu His Val Leu Leu Phe Gly Leu Ala 
                245                 250                 255     


Ala Ser Ala His Arg Asp Leu Gly Ala Ser Val Met Val Ala Lys Gly 
            260                 265                 270         


Cys Gly Gln Cys Leu Asn Phe Asp Cys Ser Phe Ile Ala Val Leu Met 
        275                 280                 285             


Leu Arg Arg Cys Leu Thr Trp Leu Arg Ala Thr Trp Leu Ala Gln Val 
    290                 295                 300                 


Leu Pro Leu Asp Gln Asn Ile Gln Phe His Gln Leu Met Gly Tyr Val 
305                 310                 315                 320 


Val Val Gly Leu Ser Leu Val His Thr Val Ala His Thr Val Asn Phe 
                325                 330                 335     


Val Leu Gln Ala Gln Ala Glu Ala Ser Pro Phe Gln Phe Trp Glu Leu 
            340                 345                 350         


Leu Leu Thr Thr Arg Pro Gly Ile Gly Trp Val His Gly Ser Ala Ser 
        355                 360                 365             


Pro Thr Gly Val Ala Leu Leu Leu Leu Leu Leu Leu Met Phe Ile Cys 
    370                 375                 380                 


Ser Ser Ser Cys Ile Arg Arg Ser Gly His Phe Glu Val Phe Tyr Trp 
385                 390                 395                 400 


Thr His Leu Ser Tyr Leu Leu Val Trp Leu Leu Leu Ile Phe His Gly 
                405                 410                 415     


Pro Asn Phe Trp Lys Trp Leu Leu Val Pro Gly Ile Leu Phe Phe Leu 
            420                 425                 430         


Glu Lys Ala Ile Gly Leu Ala Val Ser Arg Met Ala Ala Val Cys Ile 
        435                 440                 445             


Met Glu Val Asn Leu Leu Pro Ser Lys Val Thr His Leu Leu Ile Lys 
    450                 455                 460                 


Arg Pro Pro Phe Phe His Tyr Arg Pro Gly Asp Tyr Leu Tyr Leu Asn 
465                 470                 475                 480 


Ile Pro Thr Ile Ala Arg Tyr Glu Trp His Pro Phe Thr Ile Ser Ser 
                485                 490                 495     


Ala Pro Glu Gln Lys Asp Thr Ile Trp Leu His Ile Arg Ser Gln Gly 
            500                 505                 510         


Gln Trp Thr Asn Arg Leu Tyr Glu Ser Phe Lys Ala Ser Asp Pro Leu 
        515                 520                 525             


Gly Arg Gly Ser Lys Arg Leu Ser Arg Ser Val Thr Met Arg Lys Ser 
    530                 535                 540                 


Gln Arg Ser Ser Lys Gly Ser Glu Ile Leu Leu Glu Lys His Lys Phe 
545                 550                 555                 560 


Cys Asn Ile Lys Cys Tyr Ile Asp Gly Pro Tyr Gly Thr Pro Thr Arg 
                565                 570                 575     


Arg Ile Phe Ala Ser Glu His Ala Val Leu Ile Gly Ala Gly Ile Gly 
            580                 585                 590         


Ile Thr Pro Phe Ala Ser Ile Leu Gln Ser Ile Met Tyr Arg His Gln 
        595                 600                 605             


Lys Arg Lys His Thr Cys Pro Ser Cys Gln His Ser Trp Ile Glu Gly 
    610                 615                 620                 


Val Gln Asp Asn Met Lys Leu His Lys Val Asp Phe Ile Trp Ile Asn 
625                 630                 635                 640 


Arg Asp Gln Arg Ser Phe Glu Trp Phe Val Ser Leu Leu Thr Lys Leu 
                645                 650                 655     


Glu Met Asp Gln Ala Glu Glu Ala Gln Tyr Gly Arg Phe Leu Glu Leu 
            660                 665                 670         


His Met Tyr Met Thr Ser Ala Leu Gly Lys Asn Asp Met Lys Ala Ile 
        675                 680                 685             


Gly Leu Gln Met Ala Leu Asp Leu Leu Ala Asn Lys Glu Lys Lys Asp 
    690                 695                 700                 


Ser Ile Thr Gly Leu Gln Thr Arg Thr Gln Pro Gly Arg Pro Asp Trp 
705                 710                 715                 720 


Ser Lys Val Phe Gln Lys Val Ala Ala Glu Lys Lys Gly Lys Val Gln 
                725                 730                 735     


Val Phe Phe Cys Gly Ser Pro Ala Leu Ala Lys Val Leu Lys Gly His 
            740                 745                 750         


Cys Glu Lys Phe Gly Phe Arg Phe Phe Gln Glu Asn Phe 
        755                 760                 765 


<210>  5036
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  5036

Met Gly Thr Gln Ala Leu Gln Gly Phe Leu Phe Leu Leu Phe Leu Pro 
1               5                   10                  15      


Leu Leu Gln Pro Arg Gly Ala Ser Ala Gly Ser Leu His Ser Pro Gly 
            20                  25                  30          


Leu Ser Glu Cys Phe Gln Val Asn Gly Ala Asp Tyr Arg Gly His Gln 
        35                  40                  45              


Asn Arg Thr Gly Pro Arg Gly Ala Gly Arg Pro Cys Leu Phe Trp Asp 
    50                  55                  60                  


Gln Thr Gln Gln His Ser Tyr Ser Ser Ala Ser Asp Pro His Gly Arg 
65                  70                  75                  80  


Trp Gly Leu Gly Ala His Asn Phe Cys Arg Asn Pro Asp Gly Asp Val 
                85                  90                  95      


Gln Pro Trp Cys Tyr Val Ala Glu Thr Glu Glu Gly Ile Tyr Trp Arg 
            100                 105                 110         


Tyr Cys Asp Ile Pro Ser Cys His Met Pro Gly Tyr Leu Gly Cys Phe 
        115                 120                 125             


Val Asp Ser Gly Ala Pro Pro Ala Leu Ser Gly Pro Ser Gly Thr Ser 
    130                 135                 140                 


Thr Lys Leu Thr Val Gln Val Cys Leu Arg Phe Cys Arg Met Lys Gly 
145                 150                 155                 160 


Tyr Gln Leu Ala Gly Val Glu Ala Gly Tyr Ala Cys Phe Cys Gly Ser 
                165                 170                 175     


Glu Ser Asp Leu Ala Arg Gly Arg Leu Ala Pro Ala Thr Asp Cys Asp 
            180                 185                 190         


Gln Ile Cys Phe Gly His Pro Gly Gln Leu Cys Gly Gly Asp Gly Arg 
        195                 200                 205             


Leu Gly Val Tyr Glu Val Ser Val Gly Ser Cys Gln Gly Asn Trp Thr 
    210                 215                 220                 


Ala Pro Gln Gly Val Ile Tyr Ser Pro Asp Phe Pro Asp Glu Tyr Gly 
225                 230                 235                 240 


Pro Asp Arg Asn Cys Ser Trp Ala Leu Gly Pro Pro Gly Ala Ala Leu 
                245                 250                 255     


Glu Leu Thr Phe Arg Leu Phe Glu Leu Ala Asp Pro Arg Asp Arg Leu 
            260                 265                 270         


Glu Leu Arg Asp Ala Ala Ser Gly Ser Leu Leu Arg Ala Phe Asp Gly 
        275                 280                 285             


Ala Arg Pro Pro Pro Ser Gly Pro Leu Arg Leu Gly Thr Ala Ala Leu 
    290                 295                 300                 


Leu Leu Thr Phe Arg Ser Asp Ala Arg Gly His Ala Gln Gly Phe Ala 
305                 310                 315                 320 


Leu Thr Tyr Arg Gly Leu Gln Asp Ala Ala Glu Asp Pro Glu Ala Pro 
                325                 330                 335     


Glu Gly Ser Ala Gln Thr Pro Ala Ala Pro Leu Asp Gly Ala Asn Val 
            340                 345                 350         


Ser Cys Ser Pro Arg Pro Gly Ala Pro Pro Ala Ala Ile Gly Gly Ala 
        355                 360                 365             


Val Cys Trp Leu Arg Glu Lys Gly Pro Arg Arg Trp Gly Leu Pro Gly 
    370                 375                 380                 


Ala Pro Gly Glu Ala Gly Leu Cys Gly Thr Asn Ser Pro Glu Gly Trp 
385                 390                 395                 400 


Pro Cys Pro Ala Pro Pro Gly Thr Pro Arg Leu Arg Val Leu Pro Arg 
                405                 410                 415     


Ala Thr Gly Leu 
            420 


<210>  5037
<211>  628
<212>  PRT
<213>  Homo sapiens

<400>  5037

Met Ala Ile Leu Pro Leu Leu Leu Cys Leu Leu Pro Leu Ala Pro Ala 
1               5                   10                  15      


Ser Ser Pro Pro Gln Ser Ala Thr Pro Ser Pro Cys Pro Arg Arg Cys 
            20                  25                  30          


Arg Cys Gln Thr Gln Ser Leu Pro Leu Ser Val Leu Cys Pro Gly Ala 
        35                  40                  45              


Gly Leu Leu Phe Val Pro Pro Ser Leu Asp Arg Arg Ala Ala Glu Leu 
    50                  55                  60                  


Arg Leu Ala Asp Asn Phe Ile Ala Ser Val Arg Arg Arg Asp Leu Ala 
65                  70                  75                  80  


Asn Met Thr Gly Leu Leu His Leu Ser Leu Ser Arg Asn Thr Ile Arg 
                85                  90                  95      


His Val Ala Ala Gly Ala Phe Ala Asp Leu Arg Ala Leu Arg Ala Leu 
            100                 105                 110         


His Leu Asp Gly Asn Arg Leu Thr Ser Leu Gly Glu Gly Gln Leu Arg 
        115                 120                 125             


Gly Leu Val Asn Leu Arg His Leu Ile Leu Ser Asn Asn Gln Leu Ala 
    130                 135                 140                 


Ala Leu Ala Ala Gly Ala Leu Asp Asp Cys Ala Glu Thr Leu Glu Asp 
145                 150                 155                 160 


Leu Asp Leu Ser Tyr Asn Asn Leu Glu Gln Leu Pro Trp Glu Ala Leu 
                165                 170                 175     


Gly Arg Leu Gly Asn Val Asn Thr Leu Gly Leu Asp His Asn Leu Leu 
            180                 185                 190         


Ala Ser Val Pro Ala Gly Ala Phe Ser Arg Leu His Lys Leu Ala Arg 
        195                 200                 205             


Leu Asp Met Thr Ser Asn Arg Leu Thr Thr Ile Pro Pro Asp Pro Leu 
    210                 215                 220                 


Phe Ser Arg Leu Pro Leu Leu Ala Arg Pro Arg Gly Ser Pro Ala Ser 
225                 230                 235                 240 


Ala Leu Val Leu Ala Phe Gly Gly Asn Pro Leu His Cys Asn Cys Glu 
                245                 250                 255     


Leu Val Trp Leu Arg Arg Leu Ala Arg Glu Asp Asp Leu Glu Ala Cys 
            260                 265                 270         


Ala Ser Pro Pro Ala Leu Gly Gly Arg Tyr Phe Trp Ala Val Gly Glu 
        275                 280                 285             


Glu Glu Phe Val Cys Glu Pro Pro Val Val Thr His Arg Ser Pro Pro 
    290                 295                 300                 


Leu Ala Val Pro Ala Gly Arg Pro Ala Ala Leu Arg Cys Arg Ala Val 
305                 310                 315                 320 


Gly Asp Pro Glu Pro Arg Val Arg Trp Val Ser Pro Gln Gly Arg Leu 
                325                 330                 335     


Leu Gly Asn Ser Ser Arg Ala Arg Ala Phe Pro Asn Gly Thr Leu Glu 
            340                 345                 350         


Leu Leu Val Thr Glu Pro Gly Asp Gly Gly Ile Phe Thr Cys Ile Ala 
        355                 360                 365             


Ala Asn Ala Ala Gly Glu Ala Thr Ala Ala Val Glu Leu Thr Val Gly 
    370                 375                 380                 


Pro Pro Pro Pro Pro Gln Leu Ala Asn Ser Thr Ser Cys Asp Pro Pro 
385                 390                 395                 400 


Arg Asp Gly Asp Pro Asp Ala Leu Thr Pro Pro Ser Ala Ala Ser Ala 
                405                 410                 415     


Ser Ala Lys Val Ala Asp Thr Gly Pro Pro Thr Asp Arg Gly Val Gln 
            420                 425                 430         


Val Thr Glu His Gly Ala Thr Ala Ala Leu Val Gln Trp Pro Asp Gln 
        435                 440                 445             


Arg Pro Ile Pro Gly Ile Arg Met Tyr Gln Ile Gln Tyr Asn Ser Ser 
    450                 455                 460                 


Ala Asp Asp Ile Leu Val Tyr Arg Met Ile Pro Ala Glu Ser Arg Ser 
465                 470                 475                 480 


Phe Leu Leu Thr Asp Leu Ala Ser Gly Arg Thr Tyr Asp Leu Cys Val 
                485                 490                 495     


Leu Ala Val Tyr Glu Asp Ser Ala Thr Gly Leu Thr Ala Thr Arg Pro 
            500                 505                 510         


Val Gly Cys Ala Arg Phe Ser Thr Glu Pro Ala Leu Arg Pro Cys Gly 
        515                 520                 525             


Ala Pro His Ala Pro Phe Leu Gly Gly Thr Met Ile Ile Ala Leu Gly 
    530                 535                 540                 


Gly Val Ile Val Ala Ser Val Leu Val Phe Ile Phe Val Leu Leu Met 
545                 550                 555                 560 


Arg Tyr Lys Val His Gly Gly Gln Pro Pro Gly Lys Ala Lys Ile Pro 
                565                 570                 575     


Ala Pro Val Ser Ser Val Cys Ser Gln Thr Asn Gly Ala Leu Gly Pro 
            580                 585                 590         


Thr Pro Thr Pro Ala Pro Pro Ala Pro Glu Pro Ala Ala Leu Arg Ala 
        595                 600                 605             


His Thr Val Val Gln Leu Asp Cys Glu Pro Trp Gly Pro Gly His Glu 
    610                 615                 620                 


Pro Val Gly Pro 
625             


<210>  5038
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  5038

Met Trp Lys Leu Trp Arg Ala Glu Glu Gly Ala Ala Ala Leu Gly Gly 
1               5                   10                  15      


Ala Leu Phe Leu Leu Leu Phe Ala Leu Gly Val Arg Gln Leu Leu Lys 
            20                  25                  30          


Gln Arg Arg Pro Met Gly Phe Pro Pro Gly Pro Pro Gly Leu Pro Phe 
        35                  40                  45              


Ile Gly Asn Ile Tyr Ser Leu Ala Ala Ser Ser Glu Leu Pro His Val 
    50                  55                  60                  


Tyr Met Arg Lys Gln Ser Gln Val Tyr Gly Glu Ile Phe Ser Leu Asp 
65                  70                  75                  80  


Leu Gly Gly Ile Ser Thr Val Val Leu Asn Gly Tyr Asp Val Val Lys 
                85                  90                  95      


Glu Cys Leu Val His Gln Ser Glu Ile Phe Ala Asp Arg Pro Cys Leu 
            100                 105                 110         


Pro Leu Phe Met Lys Met Thr Lys Met Gly Gly Leu Leu Asn Ser Arg 
        115                 120                 125             


Tyr Gly Arg Gly Trp Val Asp His Arg Arg Leu Ala Val Asn Ser Phe 
    130                 135                 140                 


Arg Tyr Phe Gly Tyr Gly Gln Lys Ser Phe Glu Ser Lys Ile Leu Glu 
145                 150                 155                 160 


Glu Thr Lys Phe Phe Asn Asp Ala Ile Glu Thr Tyr Lys Gly Arg Pro 
                165                 170                 175     


Phe Asp Phe Lys Gln Leu Ile Thr Asn Ala Val Ser Asn Ile Thr Asn 
            180                 185                 190         


Leu Ile Ile Phe Gly Glu Arg Phe Thr Tyr Glu Asp Thr Asp Phe Gln 
        195                 200                 205             


His Met Ile Glu Leu Phe Ser Glu Asn Val Glu Leu Ala Ala Ser Ala 
    210                 215                 220                 


Ser Val Phe Leu Tyr Asn Ala Phe Pro Trp Ile Gly Ile Leu Pro Phe 
225                 230                 235                 240 


Gly Lys His Gln Gln Leu Phe Arg Asn Ala Ala Val Val Tyr Asp Phe 
                245                 250                 255     


Leu Ser Arg Leu Ile Glu Lys Ala Ser Val Asn Arg Lys Pro Gln Leu 
            260                 265                 270         


Pro Gln His Phe Val Asp Ala Tyr Leu Asp Glu Met Asp Gln Gly Lys 
        275                 280                 285             


Asn Asp Pro Ser Ser Thr Phe Ser Lys Glu Asn Leu Ile Phe Ser Val 
    290                 295                 300                 


Gly Glu Leu Ile Ile Ala Gly Thr Glu Thr Thr Thr Asn Val Leu Arg 
305                 310                 315                 320 


Trp Ala Ile Leu Phe Met Ala Leu Tyr Pro Asn Ile Gln Gly Gln Val 
                325                 330                 335     


Gln Lys Glu Ile Asp Leu Ile Met Gly Pro Asn Gly Lys Pro Ser Trp 
            340                 345                 350         


Asp Asp Lys Cys Lys Met Pro Tyr Thr Glu Ala Val Leu His Glu Val 
        355                 360                 365             


Leu Arg Phe Cys Asn Ile Val Pro Leu Gly Ile Phe His Ala Thr Ser 
    370                 375                 380                 


Glu Asp Ala Val Val Arg Gly Tyr Ser Ile Pro Lys Gly Thr Thr Val 
385                 390                 395                 400 


Ile Thr Asn Leu Tyr Ser Val His Phe Asp Glu Lys Tyr Trp Arg Asp 
                405                 410                 415     


Pro Glu Val Phe His Pro Glu Arg Phe Leu Asp Ser Ser Gly Tyr Phe 
            420                 425                 430         


Ala Lys Lys Glu Ala Leu Val Pro Phe Ser Leu Gly Arg Arg His Cys 
        435                 440                 445             


Leu Gly Glu His Leu Ala Arg Met Glu Met Phe Leu Phe Phe Thr Ala 
    450                 455                 460                 


Leu Leu Gln Arg Phe His Leu His Phe Pro His Glu Leu Val Pro Asp 
465                 470                 475                 480 


Leu Lys Pro Arg Leu Gly Met Thr Leu Gln Pro Gln Pro Tyr Leu Ile 
                485                 490                 495     


Cys Ala Glu Arg Arg 
            500     


<210>  5039
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  5039

Met Gly Lys Cys Ser Gly Arg Cys Thr Leu Val Ala Phe Cys Cys Leu 
1               5                   10                  15      


Gln Leu Val Ala Ala Leu Glu Arg Gln Ile Phe Asp Phe Leu Gly Tyr 
            20                  25                  30          


Gln Trp Ala Pro Ile Leu Ala Asn Phe Leu His Ile Met Ala Val Ile 
        35                  40                  45              


Leu Gly Ile Phe Gly Thr Val Gln Tyr Arg Ser Arg Tyr Leu Ile Leu 
    50                  55                  60                  


Tyr Ala Ala Trp Leu Val Leu Trp Val Gly Trp Asn Ala Phe Ile Ile 
65                  70                  75                  80  


Cys Phe Tyr Leu Glu Val Gly Gln Leu Ser Gln Asp Arg Asp Phe Ile 
                85                  90                  95      


Met Thr Phe Asn Thr Ser Leu His Arg Ser Trp Trp Met Glu Asn Gly 
            100                 105                 110         


Pro Gly Cys Leu Val Thr Pro Val Leu Asn Ser Arg Leu Ala Leu Glu 
        115                 120                 125             


Asp His His Val Ile Ser Val Thr Gly Cys Leu Leu Asp Tyr Pro Tyr 
    130                 135                 140                 


Ile Glu Ala Leu Ser Ser Ala Leu Gln Ile Phe Leu Ala Leu Phe Gly 
145                 150                 155                 160 


Phe Val Phe Ala Cys Tyr Val Ser Lys Val Phe Leu Glu Glu Glu Asp 
                165                 170                 175     


Ser Phe Asp Phe Ile Gly Gly Phe Asp Ser Tyr Gly Tyr Gln Ala Pro 
            180                 185                 190         


Gln Lys Thr Ser His Leu Gln Leu Gln Pro Leu Tyr Thr Ser Gly 
        195                 200                 205         


<210>  5040
<211>  1226
<212>  PRT
<213>  Homo sapiens

<400>  5040

Met Asp Arg Glu Glu Arg Lys Thr Ile Asn Gln Gly Gln Glu Asp Glu 
1               5                   10                  15      


Met Glu Ile Tyr Gly Tyr Asn Leu Ser Arg Trp Lys Leu Ala Ile Val 
            20                  25                  30          


Ser Leu Gly Val Ile Cys Ser Gly Gly Phe Leu Leu Leu Leu Leu Tyr 
        35                  40                  45              


Trp Met Pro Glu Trp Arg Val Lys Ala Thr Cys Val Arg Ala Ala Ile 
    50                  55                  60                  


Lys Asp Cys Glu Val Val Leu Leu Arg Thr Thr Asp Glu Phe Lys Met 
65                  70                  75                  80  


Trp Phe Cys Ala Lys Ile Arg Val Leu Ser Leu Glu Thr Tyr Pro Val 
                85                  90                  95      


Ser Ser Pro Lys Ser Met Ser Asn Lys Leu Ser Asn Gly His Ala Val 
            100                 105                 110         


Cys Leu Ile Glu Asn Pro Thr Glu Glu Asn Arg His Arg Ile Ser Lys 
        115                 120                 125             


Tyr Ser Gln Thr Glu Ser Gln Gln Ile Arg Tyr Phe Thr His His Ser 
    130                 135                 140                 


Val Lys Tyr Phe Trp Asn Asp Thr Ile His Asn Phe Asp Phe Leu Lys 
145                 150                 155                 160 


Gly Leu Asp Glu Gly Val Ser Cys Thr Ser Ile Tyr Glu Lys His Ser 
                165                 170                 175     


Ala Gly Leu Thr Lys Gly Met His Ala Tyr Arg Lys Leu Leu Tyr Gly 
            180                 185                 190         


Val Asn Glu Ile Ala Val Lys Val Pro Ser Val Phe Lys Leu Leu Ile 
        195                 200                 205             


Lys Glu Val Leu Asn Pro Phe Tyr Ile Phe Gln Leu Phe Ser Val Ile 
    210                 215                 220                 


Leu Trp Ser Thr Asp Glu Tyr Tyr Tyr Tyr Ala Leu Ala Ile Val Val 
225                 230                 235                 240 


Met Ser Ile Val Ser Ile Val Ser Ser Leu Tyr Ser Ile Arg Lys Gln 
                245                 250                 255     


Tyr Val Met Leu His Asp Met Val Ala Thr His Ser Thr Val Arg Val 
            260                 265                 270         


Ser Val Cys Arg Val Asn Glu Glu Ile Glu Glu Ile Phe Ser Thr Asp 
        275                 280                 285             


Leu Val Pro Gly Asp Val Met Val Ile Pro Leu Asn Gly Thr Ile Met 
    290                 295                 300                 


Pro Cys Asp Ala Val Leu Ile Asn Gly Thr Cys Ile Val Asn Glu Ser 
305                 310                 315                 320 


Met Leu Thr Gly Glu Ser Val Pro Val Thr Lys Thr Asn Leu Pro Asn 
                325                 330                 335     


Pro Ser Val Asp Val Lys Gly Ile Gly Asp Glu Leu Tyr Asn Pro Glu 
            340                 345                 350         


Thr His Lys Arg His Thr Leu Phe Cys Gly Thr Thr Val Ile Gln Thr 
        355                 360                 365             


Arg Phe Tyr Thr Gly Glu Leu Val Lys Ala Ile Val Val Arg Thr Gly 
    370                 375                 380                 


Phe Ser Thr Ser Lys Gly Gln Leu Val Arg Ser Ile Leu Tyr Pro Lys 
385                 390                 395                 400 


Pro Thr Asp Phe Lys Leu Tyr Arg Asp Ala Tyr Leu Phe Leu Leu Cys 
                405                 410                 415     


Leu Val Ala Val Ala Gly Ile Gly Phe Ile Tyr Thr Ile Ile Asn Ser 
            420                 425                 430         


Ile Leu Asn Glu Val Gln Val Gly Val Ile Ile Ile Glu Ser Leu Asp 
        435                 440                 445             


Ile Ile Thr Ile Thr Val Pro Pro Ala Leu Pro Ala Ala Met Thr Ala 
    450                 455                 460                 


Gly Ile Val Tyr Ala Gln Arg Arg Leu Lys Lys Ile Gly Ile Phe Cys 
465                 470                 475                 480 


Ile Ser Pro Gln Arg Ile Asn Ile Cys Gly Gln Leu Asn Leu Val Cys 
                485                 490                 495     


Phe Asp Lys Thr Gly Thr Leu Thr Glu Asp Gly Leu Asp Leu Trp Gly 
            500                 505                 510         


Ile Gln Arg Val Glu Asn Ala Arg Phe Leu Ser Pro Glu Glu Asn Val 
        515                 520                 525             


Cys Asn Glu Met Leu Val Lys Ser Gln Phe Val Ala Cys Met Ala Thr 
    530                 535                 540                 


Cys His Ser Leu Thr Lys Ile Glu Gly Val Leu Ser Gly Asp Pro Leu 
545                 550                 555                 560 


Asp Leu Lys Met Phe Glu Ala Ile Gly Trp Ile Leu Glu Glu Ala Thr 
                565                 570                 575     


Glu Glu Glu Thr Ala Leu His Asn Arg Ile Met Pro Thr Val Val Arg 
            580                 585                 590         


Pro Pro Lys Gln Leu Leu Pro Glu Ser Thr Pro Ala Gly Asn Gln Glu 
        595                 600                 605             


Met Glu Leu Phe Glu Leu Pro Ala Thr Tyr Glu Ile Gly Ile Val Arg 
    610                 615                 620                 


Gln Phe Pro Phe Ser Ser Ala Leu Gln Arg Met Ser Val Val Ala Arg 
625                 630                 635                 640 


Val Leu Gly Asp Arg Lys Met Asp Ala Tyr Met Lys Gly Ala Pro Glu 
                645                 650                 655     


Ala Ile Ala Gly Leu Cys Lys Pro Glu Thr Val Pro Val Asp Phe Gln 
            660                 665                 670         


Asn Val Leu Glu Asp Phe Thr Lys Gln Gly Phe Arg Val Ile Ala Leu 
        675                 680                 685             


Ala His Arg Lys Leu Glu Ser Lys Leu Thr Trp His Lys Val Gln Asn 
    690                 695                 700                 


Ile Ser Arg Asp Ala Ile Glu Asn Asn Met Asp Phe Met Gly Leu Ile 
705                 710                 715                 720 


Ile Met Gln Asn Lys Leu Lys Gln Glu Thr Pro Ala Val Leu Glu Asp 
                725                 730                 735     


Leu His Lys Ala Asn Ile Arg Thr Val Met Val Thr Gly Asp Ser Met 
            740                 745                 750         


Leu Thr Ala Val Ser Val Ala Arg Asp Cys Gly Met Ile Leu Pro Gln 
        755                 760                 765             


Asp Lys Val Ile Ile Ala Glu Ala Leu Pro Pro Lys Asp Gly Lys Val 
    770                 775                 780                 


Ala Lys Ile Asn Trp His Tyr Ala Asp Ser Leu Thr Gln Cys Ser His 
785                 790                 795                 800 


Pro Ser Ala Ile Asp Pro Glu Ala Ile Pro Val Lys Leu Val His Asp 
                805                 810                 815     


Ser Leu Glu Asp Leu Gln Met Thr Arg Tyr His Phe Ala Met Asn Gly 
            820                 825                 830         


Lys Ser Phe Ser Val Ile Leu Glu His Phe Gln Asp Leu Val Pro Lys 
        835                 840                 845             


Leu Met Leu His Gly Thr Val Phe Ala Arg Met Ala Pro Asp Gln Lys 
    850                 855                 860                 


Thr Gln Leu Ile Glu Ala Leu Gln Asn Val Asp Tyr Phe Val Gly Met 
865                 870                 875                 880 


Cys Gly Asp Gly Ala Asn Asp Cys Gly Ala Leu Lys Arg Ala His Gly 
                885                 890                 895     


Gly Ile Ser Leu Ser Glu Leu Glu Ala Ser Val Ala Ser Pro Phe Thr 
            900                 905                 910         


Ser Lys Thr Pro Ser Ile Ser Cys Val Pro Asn Leu Ile Arg Glu Gly 
        915                 920                 925             


Arg Ala Ala Leu Ile Thr Ser Phe Cys Val Phe Lys Phe Met Ala Leu 
    930                 935                 940                 


Tyr Ser Ile Ile Gln Tyr Phe Ser Val Thr Leu Leu Tyr Ser Ile Leu 
945                 950                 955                 960 


Ser Asn Leu Gly Asp Phe Gln Phe Leu Phe Ile Asp Leu Ala Ile Ile 
                965                 970                 975     


Leu Val Val Val Phe Thr Met Ser Leu Asn Pro Ala Trp Lys Glu Leu 
            980                 985                 990         


Val Ala Gln Arg Pro Pro Ser Gly  Leu Ile Ser Gly Ala  Leu Leu Phe 
        995                 1000                 1005             


Ser Val  Leu Ser Gln Ile Ile  Ile Cys Ile Gly Phe  Gln Ser Leu 
    1010                 1015                 1020             


Gly Phe  Phe Trp Val Lys Gln  Gln Pro Trp Tyr Glu  Val Trp His 
    1025                 1030                 1035             


Pro Lys  Ser Asp Ala Cys Asn  Thr Thr Gly Ser Gly  Phe Trp Asn 
    1040                 1045                 1050             


Ser Ser  His Val Asp Asn Glu  Thr Glu Leu Asp Glu  His Asn Ile 
    1055                 1060                 1065             


Gln Asn  Tyr Glu Asn Thr Thr  Val Phe Phe Ile Ser  Ser Phe Gln 
    1070                 1075                 1080             


Tyr Leu  Ile Val Ala Ile Ala  Phe Ser Lys Gly Lys  Pro Phe Arg 
    1085                 1090                 1095             


Gln Pro  Cys Tyr Lys Asn Tyr  Phe Phe Val Phe Ser  Val Ile Phe 
    1100                 1105                 1110             


Leu Tyr  Ile Phe Ile Leu Phe  Ile Met Leu Tyr Pro  Val Ala Ser 
    1115                 1120                 1125             


Val Asp  Gln Val Leu Gln Ile  Val Cys Val Pro Tyr  Gln Trp Arg 
    1130                 1135                 1140             


Val Thr  Met Leu Ile Ile Val  Leu Val Asn Ala Phe  Val Ser Ile 
    1145                 1150                 1155             


Thr Val  Glu Glu Ser Val Asp  Arg Trp Gly Lys Cys  Cys Leu Pro 
    1160                 1165                 1170             


Trp Ala  Leu Gly Cys Arg Lys  Lys Thr Pro Lys Ala  Lys Tyr Met 
    1175                 1180                 1185             


Tyr Leu  Ala Gln Glu Leu Leu  Val Asp Pro Glu Trp  Pro Pro Lys 
    1190                 1195                 1200             


Pro Gln  Thr Thr Thr Glu Ala  Lys Ala Leu Val Lys  Glu Asn Gly 
    1205                 1210                 1215             


Ser Cys  Gln Ile Ile Thr Ile  Thr 
    1220                 1225     


<210>  5041
<211>  860
<212>  PRT
<213>  Homo sapiens

<400>  5041

Met Ala Pro Ala Gly Cys Cys Cys Cys Cys Cys Phe Trp Gly Gly Ala 
1               5                   10                  15      


Val Ala Ala Ala Gly Ala Ala Arg Arg Val Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Gly Val Leu Ser Ala Gly Leu Arg Pro Gly Ala Leu Ala Thr Glu His 
        35                  40                  45              


Tyr Ser Pro Leu Ser Leu Leu Lys Gln Glu Leu Gln His Arg Gln Gln 
    50                  55                  60                  


Gln Glu Ala Pro Ala Gly Gly Gly Gly Cys Ser Pro Gln Ser Gly Asp 
65                  70                  75                  80  


Trp Gly Asp Gln Tyr Ser Ala Glu Cys Gly Glu Ser Ser Phe Leu Asn 
                85                  90                  95      


Phe His Asp Ser Asp Cys Glu Pro Lys Gly Ser Ser Pro Cys Asp Ser 
            100                 105                 110         


Leu Leu Ser Leu Asn Thr Glu Lys Ile Leu Ser Gln Ala Lys Ser Ile 
        115                 120                 125             


Ala Glu Gln Lys Arg Phe Pro Phe Ala Thr Asp Asn Asp Ser Thr Asn 
    130                 135                 140                 


Glu Glu Leu Ala Ile Ala Tyr Val Leu Ile Gly Ser Gly Leu Tyr Asp 
145                 150                 155                 160 


Glu Ala Ile Arg His Phe Ser Thr Met Leu Gln Glu Glu Pro Asp Leu 
                165                 170                 175     


Val Ser Ala Ile Tyr Gly Arg Gly Ile Ala Tyr Gly Lys Lys Gly Leu 
            180                 185                 190         


His Asp Ile Lys Asn Ala Glu Leu Ala Leu Phe Glu Leu Ser Arg Val 
        195                 200                 205             


Ile Thr Leu Glu Pro Asp Arg Pro Glu Val Phe Glu Gln Arg Ala Glu 
    210                 215                 220                 


Ile Leu Ser Pro Leu Gly Arg Ile Asn Glu Ala Val Asn Asp Leu Thr 
225                 230                 235                 240 


Lys Ala Ile Gln Leu Gln Pro Ser Ala Arg Leu Tyr Arg His Arg Gly 
                245                 250                 255     


Thr Leu Tyr Phe Ile Ser Glu Asp Tyr Ala Thr Ala His Glu Asp Phe 
            260                 265                 270         


Gln Gln Ser Leu Glu Leu Asn Lys Asn Gln Pro Ile Ala Met Leu Tyr 
        275                 280                 285             


Lys Gly Leu Thr Phe Phe His Arg Gly Leu Leu Lys Glu Ala Ile Glu 
    290                 295                 300                 


Ser Phe Lys Glu Ala Leu Lys Gln Lys Val Asp Phe Ile Asp Ala Tyr 
305                 310                 315                 320 


Lys Ser Leu Gly Gln Ala Tyr Arg Glu Leu Gly Asn Phe Glu Ala Ala 
                325                 330                 335     


Thr Glu Ser Phe Gln Lys Ala Leu Leu Leu Asn Gln Asn His Val Gln 
            340                 345                 350         


Thr Leu Gln Leu Arg Gly Met Met Leu Tyr His His Gly Ser Leu Gln 
        355                 360                 365             


Glu Ala Leu Lys Asn Phe Lys Arg Cys Leu Gln Leu Glu Pro Tyr Asn 
    370                 375                 380                 


Glu Val Cys Gln Tyr Met Lys Gly Leu Ser His Val Ala Met Gly Gln 
385                 390                 395                 400 


Phe Tyr Glu Gly Ile Lys Ala Gln Thr Lys Val Met Leu Asn Asp Pro 
                405                 410                 415     


Leu Pro Gly Gln Lys Ala Ser Pro Glu Tyr Leu Lys Val Lys Tyr Leu 
            420                 425                 430         


Arg Glu Tyr Ser Arg Tyr Leu His Ala His Leu Asp Thr Pro Leu Thr 
        435                 440                 445             


Glu Tyr Asn Ile Asp Val Asp Leu Pro Gly Ser Phe Lys Asp His Trp 
    450                 455                 460                 


Ala Lys Asn Leu Pro Phe Leu Ile Glu Asp Tyr Glu Glu Gln Pro Gly 
465                 470                 475                 480 


Leu Gln Pro His Ile Lys Asp Val Leu His Gln Asn Phe Glu Ser Tyr 
                485                 490                 495     


Lys Pro Glu Val Gln Glu Leu Ile Cys Val Ala Asp Arg Leu Gly Ser 
            500                 505                 510         


Leu Met Gln Tyr Glu Thr Pro Gly Phe Leu Pro Asn Lys Arg Ile His 
        515                 520                 525             


Arg Ala Met Gly Leu Ala Ala Leu Glu Val Met Gln Ala Val Gln Arg 
    530                 535                 540                 


Thr Trp Thr Asn Ser Lys Val Arg Met Asn Gly Lys Thr Arg Leu Met 
545                 550                 555                 560 


Gln Trp Arg Asp Met Phe Asp Ile Ala Val Lys Trp Arg Arg Ile Ala 
                565                 570                 575     


Asp Pro Asp Gln Pro Val Leu Trp Leu Asp Gln Met Pro Ala Arg Ser 
            580                 585                 590         


Leu Ser Arg Gly Phe Asn Asn His Ile Asn Leu Ile Arg Gly Gln Val 
        595                 600                 605             


Ile Asn Met Arg Tyr Leu Glu Tyr Phe Glu Lys Ile Leu His Phe Ile 
    610                 615                 620                 


Lys Asp Arg Ile Leu Val Tyr His Gly Ala Asn Asn Pro Lys Gly Leu 
625                 630                 635                 640 


Leu Glu Val Arg Glu Ala Leu Glu Lys Val His Lys Val Glu Asp Leu 
                645                 650                 655     


Leu Pro Ile Met Lys Gln Phe Asn Thr Lys Thr Lys Asp Gly Phe Thr 
            660                 665                 670         


Val Asn Thr Lys Val Pro Ser Leu Lys Asp Gln Gly Lys Glu Tyr Asp 
        675                 680                 685             


Gly Phe Thr Ile Thr Ile Thr Gly Asp Lys Val Gly Asn Ile Leu Phe 
    690                 695                 700                 


Ser Val Glu Thr Gln Thr Thr Glu Glu Arg Thr Gln Leu Tyr His Ala 
705                 710                 715                 720 


Glu Ile Asp Ala Leu Tyr Lys Asp Leu Thr Ala Lys Gly Lys Val Leu 
                725                 730                 735     


Ile Leu Ser Ser Glu Phe Gly Glu Ala Asp Ala Val Cys Asn Leu Ile 
            740                 745                 750         


Leu Ser Leu Val Tyr Tyr Phe Tyr Asn Leu Met Pro Leu Ser Arg Gly 
        755                 760                 765             


Ser Ser Val Ile Ala Tyr Ser Val Ile Val Gly Ala Leu Met Ala Ser 
    770                 775                 780                 


Gly Lys Glu Val Ala Gly Lys Ile Pro Lys Gly Lys Leu Val Asp Phe 
785                 790                 795                 800 


Glu Ala Met Thr Ala Pro Gly Ser Glu Ala Phe Ser Lys Val Ala Lys 
                805                 810                 815     


Ser Trp Met Asn Leu Lys Ser Ile Ser Pro Ser Tyr Lys Thr Leu Pro 
            820                 825                 830         


Ser Val Ser Glu Thr Phe Pro Thr Leu Arg Ser Met Ile Glu Val Leu 
        835                 840                 845             


Asn Thr Asp Ser Ser Pro Arg Cys Leu Lys Lys Leu 
    850                 855                 860 


<210>  5042
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  5042

Met Ala Ala Pro Thr Pro Ala Arg Pro Val Leu Thr His Leu Leu Val 
1               5                   10                  15      


Ala Leu Phe Gly Met Gly Ser Trp Ala Ala Val Asn Gly Ile Trp Val 
            20                  25                  30          


Glu Leu Pro Val Val Val Lys Glu Leu Pro Glu Gly Trp Ser Leu Pro 
        35                  40                  45              


Ser Tyr Val Ser Val Leu Val Ala Leu Gly Asn Leu Gly Leu Leu Val 
    50                  55                  60                  


Val Thr Leu Trp Arg Arg Leu Ala Pro Gly Lys Asp Glu Gln Val Pro 
65                  70                  75                  80  


Ile Arg Val Val Gln Val Leu Gly Met Val Gly Thr Ala Leu Leu Ala 
                85                  90                  95      


Ser Leu Trp His His Val Ala Pro Val Ala Gly Gln Leu His Ser Val 
            100                 105                 110         


Ala Phe Leu Ala Leu Ala Phe Val Leu Ala Leu Ala Cys Cys Ala Ser 
        115                 120                 125             


Asn Val Thr Phe Leu Pro Phe Leu Ser His Leu Pro Pro Arg Phe Leu 
    130                 135                 140                 


Arg Ser Phe Phe Leu Gly Gln Gly Leu Ser Ala Leu Leu Pro Cys Val 
145                 150                 155                 160 


Leu Ala Leu Val Gln Gly Val Gly Arg Leu Glu Cys Pro Pro Ala Pro 
                165                 170                 175     


Ile Asn Gly Thr Pro Gly Pro Pro Leu Asp Phe Leu Glu Arg Phe Pro 
            180                 185                 190         


Ala Ser Thr Phe Phe Trp Ala Leu Thr Ala Leu Leu Val Ala Ser Ala 
        195                 200                 205             


Ala Ala Phe Gln Gly Leu Leu Leu Leu Leu Pro Pro Pro Pro Ser Val 
    210                 215                 220                 


Pro Thr Gly Glu Leu Gly Ser Gly Leu Gln Val Gly Ala Pro Gly Ala 
225                 230                 235                 240 


Glu Glu Glu Val Glu Glu Ser Ser Pro Leu Gln Glu Pro Pro Ser Gln 
                245                 250                 255     


Ala Ala Gly Thr Thr Pro Gly Pro Asp Pro Lys Ala Tyr Gln Leu Leu 
            260                 265                 270         


Ser Ala Arg Ser Ala Cys Leu Leu Gly Leu Leu Ala Ala Thr Asn Ala 
        275                 280                 285             


Leu Thr Asn Gly Val Leu Pro Ala Val Gln Ser Phe Ser Cys Leu Pro 
    290                 295                 300                 


Tyr Gly Arg Leu Ala Tyr His Leu Ala Val Val Leu Gly Ser Ala Ala 
305                 310                 315                 320 


Asn Pro Leu Ala Cys Phe Leu Ala Met Gly Val Leu Cys Arg Ser Leu 
                325                 330                 335     


Ala Gly Leu Gly Gly Leu Ser Leu Leu Gly Val Phe Cys Gly Gly Tyr 
            340                 345                 350         


Leu Met Ala Leu Ala Val Leu Ser Pro Cys Pro Pro Leu Val Gly Thr 
        355                 360                 365             


Ser Ala Gly Val Val Leu Val Val Leu Ser Trp Val Leu Cys Leu Gly 
    370                 375                 380                 


Val Phe Ser Tyr Val Lys Val Ala Ala Ser Ser Leu Leu His Gly Gly 
385                 390                 395                 400 


Gly Arg Pro Ala Leu Leu Ala Ala Gly Val Ala Ile Gln Val Gly Ser 
                405                 410                 415     


Leu Leu Gly Ala Val Ala Met Phe Pro Pro Thr Ser Ile Tyr His Val 
            420                 425                 430         


Phe His Ser Arg Lys Asp Cys Ala Asp Pro Cys Asp Ser 
        435                 440                 445 


<210>  5043
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  5043

Met Asn Gln Glu Asn Arg Ser Ser Phe Phe Trp Leu Leu Val Ile Phe 
1               5                   10                  15      


Thr Phe Leu Leu Lys Ile Thr Ala Ser Phe Ser Met Ser Ala Tyr Val 
            20                  25                  30          


Thr Val Thr Tyr Tyr Asn Glu Thr Ser Asn Tyr Thr Ala Ile Glu Thr 
        35                  40                  45              


Cys Glu Cys Gly Val Tyr Gly Leu Ala Ser Pro Val Ala Asn Ala Met 
    50                  55                  60                  


Gly Val Val Gly Ile Pro Lys Asn Asn Asn Tyr Gln Ala Cys Asp His 
65                  70                  75                  80  


Asn Thr Glu Phe Ser Asn Thr Lys Lys Pro Trp Ile Ala Leu Ile Glu 
                85                  90                  95      


Arg Gly Asn Cys Thr Phe Ser Glu Lys Ile Gln Thr Ala Gly Arg Arg 
            100                 105                 110         


Asn Ala Asp Ala Val Val Ile Tyr Asn Ala Pro Glu Thr Gly Asn Gln 
        115                 120                 125             


Thr Ile Gln Met Ala Asn Phe Gly Ala Val Asp Ile Val Ala Ile Met 
    130                 135                 140                 


Ile Gly Asn Leu Lys Gly Thr Lys Ile Leu Gln Ser Ile Gln Arg Gly 
145                 150                 155                 160 


Ile Gln Val Thr Met Val Ile Glu Val Gly Lys Lys His Gly Pro Trp 
                165                 170                 175     


Val Asn His Tyr Ser Ile Phe Phe Val Ser Val Ser Phe Phe Ile Ile 
            180                 185                 190         


Thr Ala Ala Thr Val Gly Tyr Phe Ile Phe Tyr Ser Ala Arg Arg Leu 
        195                 200                 205             


Arg Asn Ala Arg Ala Gln Ser Arg Lys Gln Arg Gln Leu Lys Ala Asp 
    210                 215                 220                 


Ala Lys Lys Ala Ile Gly Arg Leu Gln Leu Arg Thr Leu Lys Gln Gly 
225                 230                 235                 240 


Asp Lys Glu Ile Gly Pro Asp Gly Asp Ser Cys Ala Val Cys Ile Glu 
                245                 250                 255     


Leu Tyr Lys Pro Asn Asp Leu Val Arg Ile Leu Thr Cys Asn His Ile 
            260                 265                 270         


Phe His Lys Thr Cys Val Asp Pro Trp Leu Leu Glu His Arg Thr Cys 
        275                 280                 285             


Pro Met Cys Lys Cys Asp Ile Leu Lys Ala Leu Gly Ile Glu Val Asp 
    290                 295                 300                 


Val Glu Asp Gly Ser Val Ser Leu Gln Val Pro Val Ser Asn Glu Ile 
305                 310                 315                 320 


Ser Asn Ser Ala Ser Ser His Glu Glu Asp Asn Arg Ser Glu Thr Ala 
                325                 330                 335     


Ser Ser Gly Tyr Ala Ser Val Gln Gly Thr Asp Glu Pro Pro Leu Glu 
            340                 345                 350         


Glu His Val Gln Ser Thr Asn Glu Ser Leu Gln Leu Val Asn His Glu 
        355                 360                 365             


Ala Asn Ser Val Ala Val Asp Val Ile Pro His Val Asp Asn Pro Thr 
    370                 375                 380                 


Phe Glu Glu Asp Glu Thr Pro Asn Gln Glu Thr Ala Val Arg Glu Ile 
385                 390                 395                 400 


Lys Ser 
        


<210>  5044
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  5044

Met Glu Ser Gly Gly Arg Pro Ser Leu Cys Gln Phe Ile Leu Leu Gly 
1               5                   10                  15      


Thr Thr Ser Val Val Thr Ala Ala Leu Tyr Ser Val Tyr Arg Gln Lys 
            20                  25                  30          


Ala Arg Val Ser Gln Glu Leu Lys Gly Ala Lys Lys Val His Leu Gly 
        35                  40                  45              


Glu Asp Leu Lys Ser Ile Leu Ser Glu Ala Pro Gly Lys Cys Val Pro 
    50                  55                  60                  


Tyr Ala Val Ile Glu Gly Ala Val Arg Ser Val Lys Glu Thr Leu Asn 
65                  70                  75                  80  


Ser Gln Phe Val Glu Asn Cys Lys Gly Val Ile Gln Arg Leu Thr Leu 
                85                  90                  95      


Gln Glu His Lys Met Val Trp Asn Arg Thr Thr His Leu Trp Asn Asp 
            100                 105                 110         


Cys Ser Lys Ile Ile His Gln Arg Thr Asn Thr Val Pro Phe Asp Leu 
        115                 120                 125             


Val Pro His Glu Asp Gly Val Asp Val Ala Val Arg Val Leu Lys Pro 
    130                 135                 140                 


Leu Asp Ser Val Asp Leu Gly Leu Glu Thr Val Tyr Glu Lys Phe His 
145                 150                 155                 160 


Pro Ser Ile Gln Ser Phe Thr Asp Val Ile Gly His Tyr Ile Ser Gly 
                165                 170                 175     


Glu Arg Pro Lys Gly Ile Gln Glu Thr Glu Glu Met Leu Lys Val Gly 
            180                 185                 190         


Ala Thr Leu Thr Gly Val Gly Glu Leu Val Leu Asp Asn Asn Ser Val 
        195                 200                 205             


Arg Leu Gln Pro Pro Lys Gln Gly Met Gln Tyr Tyr Leu Ser Ser Gln 
    210                 215                 220                 


Asp Phe Asp Ser Leu Leu Gln Arg Gln Glu Ser Ser Val Arg Leu Trp 
225                 230                 235                 240 


Lys Val Leu Ala Leu Val Phe Gly Phe Ala Thr Cys Ala Thr Leu Phe 
                245                 250                 255     


Phe Ile Leu Arg Lys Gln Tyr Leu Gln Arg Gln Glu Arg Leu Arg Leu 
            260                 265                 270         


Lys Gln Met Gln Glu Glu Phe Gln Glu His Glu Ala Gln Leu Leu Ser 
        275                 280                 285             


Arg Ala Lys Pro Glu Asp Arg Glu Ser Leu Lys Ser Ala Cys Val Val 
    290                 295                 300                 


Cys Leu Ser Ser Phe Lys Ser Cys Val Phe Leu Glu Cys Gly His Val 
305                 310                 315                 320 


Cys Ser Cys Thr Glu Cys Tyr Arg Ala Leu Pro Glu Pro Lys Lys Cys 
                325                 330                 335     


Pro Ile Cys Arg Gln Ala Ile Thr Arg Val Ile Pro Leu Tyr Asn Ser 
            340                 345                 350         


<210>  5045
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  5045

Met Asn Glu Pro Thr Glu Asn Arg Leu Gly Cys Ser Arg Thr Pro Glu 
1               5                   10                  15      


Pro Asp Ile Arg Leu Arg Lys Gly His Gln Leu Asp Gly Thr Arg Arg 
            20                  25                  30          


Gly Asp Asn Asp Ser His Gln Gly Asp Leu Glu Pro Ile Leu Glu Ala 
        35                  40                  45              


Ser Val Leu Ser Ser His His Lys Lys Ser Ser Glu Glu His Glu Tyr 
    50                  55                  60                  


Ser Asp Glu Ala Pro Gln Glu Asp Glu Gly Phe Met Gly Met Ser Pro 
65                  70                  75                  80  


Leu Leu Gln Ala His His Ala Met Glu Lys Met Glu Glu Phe Val Cys 
                85                  90                  95      


Lys Val Trp Glu Gly Arg Trp Arg Val Ile Pro His Asp Val Leu Pro 
            100                 105                 110         


Asp Trp Leu Lys Asp Asn Asp Phe Leu Leu His Gly His Arg Pro Pro 
        115                 120                 125             


Met Pro Ser Phe Arg Ala Cys Phe Lys Ser Ile Phe Arg Ile His Thr 
    130                 135                 140                 


Glu Thr Gly Asn Ile Trp Thr His Leu Leu Gly Cys Val Phe Phe Leu 
145                 150                 155                 160 


Cys Leu Gly Ile Phe Tyr Met Phe Arg Pro Asn Ile Ser Phe Val Ala 
                165                 170                 175     


Pro Leu Gln Glu Lys Val Val Phe Gly Leu Phe Phe Leu Gly Ala Ile 
            180                 185                 190         


Leu Cys Leu Ser Phe Ser Trp Leu Phe His Thr Val Tyr Cys His Ser 
        195                 200                 205             


Glu Gly Val Ser Arg Leu Phe Ser Lys Leu Asp Tyr Ser Gly Ile Ala 
    210                 215                 220                 


Leu Leu Ile Met Gly Ser Phe Val Pro Trp Leu Tyr Tyr Ser Phe Tyr 
225                 230                 235                 240 


Cys Asn Pro Gln Pro Cys Phe Ile Tyr Leu Ile Val Ile Cys Val Leu 
                245                 250                 255     


Gly Ile Ala Ala Ile Ile Val Ser Gln Trp Asp Met Phe Ala Thr Pro 
            260                 265                 270         


Gln Tyr Arg Gly Val Arg Ala Gly Val Phe Leu Gly Leu Gly Leu Ser 
        275                 280                 285             


Gly Ile Ile Pro Thr Leu His Tyr Val Ile Ser Glu Gly Phe Leu Lys 
    290                 295                 300                 


Ala Ala Thr Ile Gly Gln Ile Gly Trp Leu Met Leu Met Ala Ser Leu 
305                 310                 315                 320 


Tyr Ile Thr Gly Ala Ala Leu Tyr Ala Ala Arg Ile Pro Glu Arg Phe 
                325                 330                 335     


Phe Pro Gly Lys Cys Asp Ile Trp Phe His Ser His Gln Leu Phe His 
            340                 345                 350         


Ile Phe Val Val Ala Gly Ala Phe Val His Phe His Gly Val Ser Asn 
        355                 360                 365             


Leu Gln Glu Phe Arg Phe Met Ile Gly Gly Gly Cys Ser Glu Glu Asp 
    370                 375                 380                 


Ala Leu 
385     


<210>  5046
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  5046

Met Leu Ser Ser Phe Asn Glu Trp Phe Trp Gln Asp Arg Phe Trp Leu 
1               5                   10                  15      


Pro Pro Asn Val Thr Trp Thr Glu Leu Glu Asp Arg Asp Gly Arg Val 
            20                  25                  30          


Tyr Pro His Pro Gln Asp Leu Leu Ala Ala Leu Pro Leu Ala Leu Val 
        35                  40                  45              


Leu Leu Ala Met Arg Leu Ala Phe Glu Arg Phe Ile Gly Leu Pro Leu 
    50                  55                  60                  


Ser Arg Trp Leu Gly Val Arg Asp Gln Thr Arg Arg Gln Val Lys Pro 
65                  70                  75                  80  


Asn Ala Thr Leu Glu Lys His Phe Leu Thr Glu Gly His Arg Pro Lys 
                85                  90                  95      


Glu Pro Gln Leu Ser Leu Leu Ala Ala Gln Cys Gly Leu Thr Leu Gln 
            100                 105                 110         


Gln Thr Gln Arg Trp Phe Arg Arg Arg Arg Asn Gln Asp Arg Pro Gln 
        115                 120                 125             


Leu Thr Lys Lys Phe Cys Glu Ala Ser Trp Arg Phe Leu Phe Tyr Leu 
    130                 135                 140                 


Ser Ser Phe Val Gly Gly Leu Ser Val Leu Tyr His Glu Ser Trp Leu 
145                 150                 155                 160 


Trp Ala Pro Val Met Cys Trp Asp Arg Tyr Pro Asn Gln Thr Leu Lys 
                165                 170                 175     


Pro Ser Leu Tyr Trp Trp Tyr Leu Leu Glu Leu Gly Phe Tyr Leu Ser 
            180                 185                 190         


Leu Leu Ile Arg Leu Pro Phe Asp Val Lys Arg Lys Asp Phe Lys Glu 
        195                 200                 205             


Gln Val Ile His His Phe Val Ala Val Ile Leu Met Thr Phe Ser Tyr 
    210                 215                 220                 


Ser Ala Asn Leu Leu Arg Ile Gly Ser Leu Val Leu Leu Leu His Asp 
225                 230                 235                 240 


Ser Ser Asp Tyr Leu Leu Glu Ala Cys Lys Met Val Asn Tyr Met Gln 
                245                 250                 255     


Tyr Gln Gln Val Cys Asp Ala Leu Phe Leu Ile Phe Ser Phe Val Phe 
            260                 265                 270         


Phe Tyr Thr Arg Leu Val Leu Phe Pro Thr Gln Ile Leu Tyr Thr Thr 
        275                 280                 285             


Tyr Tyr Glu Ser Ile Ser Asn Arg Gly Pro Phe Phe Gly Tyr Tyr Phe 
    290                 295                 300                 


Phe Asn Gly Leu Leu Met Leu Leu Gln Leu Leu His Val Phe Trp Ser 
305                 310                 315                 320 


Cys Leu Ile Leu Arg Met Leu Tyr Ser Phe Met Lys Lys Gly Gln Met 
                325                 330                 335     


Glu Lys Asp Ile Arg Ser Asp Val Glu Glu Ser Asp Ser Ser Glu Glu 
            340                 345                 350         


Ala Ala Ala Ala Gln Glu Pro Leu Gln Leu Lys Asn Gly Ala Ala Gly 
        355                 360                 365             


Gly Pro Arg Pro Ala Pro Thr Asp Gly Pro Arg Ser Arg Val Ala Gly 
    370                 375                 380                 


Arg Leu Thr Asn Arg His Thr Thr Ala Thr 
385                 390                 


<210>  5047
<211>  368
<212>  PRT
<213>  Homo sapiens

<400>  5047

Met Ala Tyr Ser Thr Val Gln Arg Val Ala Leu Ala Ser Gly Leu Val 
1               5                   10                  15      


Leu Ala Leu Ser Leu Leu Leu Pro Lys Ala Phe Leu Ser Arg Gly Lys 
            20                  25                  30          


Arg Gln Glu Pro Pro Pro Thr Pro Glu Gly Lys Leu Gly Arg Phe Pro 
        35                  40                  45              


Pro Met Met His His His Gln Ala Pro Ser Asp Gly Gln Thr Pro Gly 
    50                  55                  60                  


Ala Arg Phe Gln Arg Ser His Leu Ala Glu Ala Phe Ala Lys Ala Lys 
65                  70                  75                  80  


Gly Ser Gly Gly Gly Ala Gly Gly Gly Gly Ser Gly Arg Gly Leu Met 
                85                  90                  95      


Gly Gln Ile Ile Pro Ile Tyr Gly Phe Gly Ile Phe Leu Tyr Ile Leu 
            100                 105                 110         


Tyr Ile Leu Phe Lys Leu Ser Lys Gly Lys Thr Thr Ala Glu Asp Gly 
        115                 120                 125             


Lys Cys Tyr Thr Ala Met Pro Gly Asn Thr His Arg Lys Ile Thr Ser 
    130                 135                 140                 


Phe Glu Leu Ala Gln Leu Gln Glu Lys Leu Lys Glu Thr Glu Ala Ala 
145                 150                 155                 160 


Met Glu Lys Leu Ile Asn Arg Val Gly Pro Asn Gly Glu Arg Ala Gln 
                165                 170                 175     


Thr Val Thr Ser Asp Gln Glu Lys Arg Leu Leu His Gln Leu Arg Glu 
            180                 185                 190         


Ile Thr Arg Val Met Lys Glu Gly Lys Phe Ile Asp Arg Phe Ser Pro 
        195                 200                 205             


Glu Lys Glu Ala Glu Glu Ala Pro Tyr Met Glu Asp Trp Glu Gly Tyr 
    210                 215                 220                 


Pro Glu Glu Thr Tyr Pro Ile Tyr Asp Leu Ser Asp Cys Ile Lys Arg 
225                 230                 235                 240 


Arg Gln Glu Thr Ile Leu Val Asp Tyr Pro Asp Pro Lys Glu Leu Ser 
                245                 250                 255     


Ala Glu Glu Ile Ala Glu Arg Met Gly Met Ile Glu Glu Glu Glu Ser 
            260                 265                 270         


Asp His Leu Gly Trp Glu Ser Leu Pro Thr Asp Pro Arg Ala Gln Glu 
        275                 280                 285             


Asp Asn Ser Val Thr Ser Cys Asp Pro Lys Pro Glu Thr Cys Ser Cys 
    290                 295                 300                 


Cys Phe His Glu Asp Glu Asp Pro Ala Val Leu Ala Glu Asn Ala Gly 
305                 310                 315                 320 


Phe Ser Ala Asp Ser Tyr Pro Glu Gln Glu Glu Thr Thr Lys Glu Glu 
                325                 330                 335     


Trp Ser Gln Asp Phe Lys Asp Glu Gly Leu Gly Ile Ser Thr Asp Lys 
            340                 345                 350         


Ala Tyr Thr Gly Ser Met Leu Arg Lys Arg Asn Pro Gln Gly Leu Glu 
        355                 360                 365             


<210>  5048
<211>  686
<212>  PRT
<213>  Homo sapiens

<400>  5048

Met Lys Pro Ser Trp Leu Gln Cys Arg Lys Val Thr Ser Ala Gly Gly 
1               5                   10                  15      


Leu Gly Gly Pro Leu Pro Gly Ser Ser Pro Ala Arg Gly Ala Gly Ala 
            20                  25                  30          


Ala Leu Arg Ala Leu Val Val Pro Gly Pro Arg Gly Gly Leu Gly Gly 
        35                  40                  45              


Arg Gly Cys Arg Ala Leu Ser Ser Gly Ser Gly Ser Glu Tyr Lys Thr 
    50                  55                  60                  


His Phe Ala Ala Ser Val Thr Asp Pro Glu Arg Phe Trp Gly Lys Ala 
65                  70                  75                  80  


Ala Glu Gln Ile Ser Trp Tyr Lys Pro Trp Thr Lys Thr Leu Glu Asn 
                85                  90                  95      


Lys His Ser Pro Ser Thr Arg Trp Phe Val Glu Gly Met Leu Asn Ile 
            100                 105                 110         


Cys Tyr Asn Ala Val Asp Arg His Ile Glu Asn Gly Lys Gly Asp Lys 
        115                 120                 125             


Ile Ala Ile Ile Tyr Asp Ser Pro Val Thr Asn Thr Lys Ala Thr Phe 
    130                 135                 140                 


Thr Tyr Lys Glu Val Leu Glu Gln Val Ser Lys Leu Ala Gly Val Leu 
145                 150                 155                 160 


Val Lys His Gly Ile Lys Lys Gly Asp Thr Val Val Ile Tyr Met Pro 
                165                 170                 175     


Met Ile Pro Gln Ala Met Tyr Thr Met Leu Ala Cys Ala Arg Ile Gly 
            180                 185                 190         


Ala Ile His Ser Leu Ile Phe Gly Gly Phe Ala Ser Lys Glu Leu Ser 
        195                 200                 205             


Ser Arg Ile Asp His Val Lys Pro Lys Val Val Val Thr Ala Ser Phe 
    210                 215                 220                 


Gly Ile Glu Pro Gly Arg Arg Val Glu Tyr Val Pro Leu Val Glu Glu 
225                 230                 235                 240 


Ala Leu Lys Ile Gly Gln His Lys Pro Asp Lys Ile Leu Ile Tyr Asn 
                245                 250                 255     


Arg Pro Asn Met Glu Ala Val Pro Leu Ala Pro Gly Arg Asp Leu Asp 
            260                 265                 270         


Trp Asp Glu Glu Met Ala Lys Ala Gln Ser His Asp Cys Val Pro Val 
        275                 280                 285             


Leu Ser Glu His Pro Leu Tyr Ile Leu Tyr Thr Ser Gly Thr Thr Gly 
    290                 295                 300                 


Leu Pro Lys Gly Val Ile Arg Pro Thr Gly Gly Tyr Ala Val Met Leu 
305                 310                 315                 320 


His Trp Ser Met Ser Ser Ile Tyr Gly Leu Gln Pro Gly Glu Val Trp 
                325                 330                 335     


Trp Ala Ala Ser Asp Leu Gly Trp Val Val Gly His Ser Tyr Ile Cys 
            340                 345                 350         


Tyr Gly Pro Leu Leu His Gly Asn Thr Thr Val Leu Tyr Glu Gly Lys 
        355                 360                 365             


Pro Val Gly Thr Pro Asp Ala Gly Ala Tyr Phe Arg Val Leu Ala Glu 
    370                 375                 380                 


His Gly Val Ala Ala Leu Phe Thr Ala Pro Thr Ala Ile Arg Ala Ile 
385                 390                 395                 400 


Arg Gln Gln Asp Pro Gly Ala Ala Leu Gly Lys Gln Tyr Ser Leu Thr 
                405                 410                 415     


Arg Phe Lys Thr Leu Phe Val Ala Gly Glu Arg Cys Asp Val Glu Thr 
            420                 425                 430         


Leu Glu Trp Ser Lys Asn Val Phe Arg Val Pro Val Leu Asp His Trp 
        435                 440                 445             


Trp Gln Thr Glu Thr Gly Ser Pro Ile Thr Ala Ser Cys Val Gly Leu 
    450                 455                 460                 


Gly Asn Ser Lys Thr Pro Pro Pro Gly Gln Ala Gly Lys Ser Val Pro 
465                 470                 475                 480 


Gly Tyr Asn Val Met Ile Leu Asp Asp Asn Met Gln Lys Leu Lys Ala 
                485                 490                 495     


Arg Cys Leu Gly Asn Ile Val Val Lys Leu Pro Leu Pro Pro Gly Ala 
            500                 505                 510         


Phe Ser Gly Leu Trp Lys Asn Gln Glu Ala Phe Lys His Leu Tyr Phe 
        515                 520                 525             


Glu Lys Phe Pro Gly Tyr Tyr Asp Thr Met Asp Ala Gly Tyr Met Asp 
    530                 535                 540                 


Glu Glu Gly Tyr Leu Tyr Val Met Ser Arg Val Asp Asp Val Ile Asn 
545                 550                 555                 560 


Val Ala Gly His Arg Ile Ser Ala Gly Ala Ile Glu Glu Ser Ile Leu 
                565                 570                 575     


Ser His Gly Thr Val Ala Asp Cys Ala Val Val Gly Lys Glu Asp Pro 
            580                 585                 590         


Leu Lys Gly His Val Pro Leu Ala Leu Cys Val Leu Arg Lys Asp Ile 
        595                 600                 605             


Asn Ala Thr Glu Glu Gln Val Leu Glu Glu Ile Val Lys His Val Arg 
    610                 615                 620                 


Gln Asn Ile Gly Pro Val Ala Ala Phe Arg Asn Ala Val Phe Val Lys 
625                 630                 635                 640 


Gln Leu Pro Lys Thr Arg Ser Gly Lys Ile Pro Arg Ser Ala Leu Ser 
                645                 650                 655     


Ala Ile Val Asn Gly Lys Pro Tyr Lys Ile Thr Ser Thr Ile Glu Asp 
            660                 665                 670         


Pro Ser Ile Phe Gly His Val Glu Glu Met Leu Lys Gln Ala 
        675                 680                 685     


<210>  5049
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  5049

Met Ala Ala Ser Ala Gly Ala Gly Ala Val Ile Ala Ala Pro Asp Ser 
1               5                   10                  15      


Arg Arg Trp Leu Trp Ser Val Leu Ala Ala Ala Leu Gly Leu Leu Thr 
            20                  25                  30          


Ala Gly Val Ser Ala Leu Glu Val Tyr Thr Pro Lys Glu Ile Phe Val 
        35                  40                  45              


Ala Asn Gly Thr Gln Gly Lys Leu Thr Cys Lys Phe Lys Ser Thr Ser 
    50                  55                  60                  


Thr Thr Gly Gly Leu Thr Ser Val Ser Trp Ser Phe Gln Pro Glu Gly 
65                  70                  75                  80  


Ala Asp Thr Thr Val Ser Phe Phe His Tyr Ser Gln Gly Gln Val Tyr 
                85                  90                  95      


Leu Gly Asn Tyr Pro Pro Phe Lys Asp Arg Ile Ser Trp Ala Gly Asp 
            100                 105                 110         


Leu Asp Lys Lys Asp Ala Ser Ile Asn Ile Glu Asn Met Gln Phe Ile 
        115                 120                 125             


His Asn Gly Thr Tyr Ile Cys Asp Val Lys Asn Pro Pro Asp Ile Val 
    130                 135                 140                 


Val Gln Pro Gly His Ile Arg Leu Tyr Val Val Glu Lys Glu Asn Leu 
145                 150                 155                 160 


Pro Val Phe Pro Val Trp Val Val Val Gly Ile Val Thr Ala Val Val 
                165                 170                 175     


Leu Gly Leu Thr Leu Leu Ile Ser Met Ile Leu Ala Val Leu Tyr Arg 
            180                 185                 190         


Arg Lys Asn Ser Lys Arg Asp Tyr Thr Gly Ala Gln Ser Tyr Met His 
        195                 200                 205             


Ser 
    


<210>  5050
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  5050

Met Arg Arg Leu Thr Arg Arg Leu Val Leu Pro Val Phe Gly Val Leu 
1               5                   10                  15      


Trp Ile Thr Val Leu Leu Phe Phe Trp Val Thr Lys Arg Lys Leu Glu 
            20                  25                  30          


Val Pro Thr Gly Pro Glu Val Gln Thr Pro Lys Pro Ser Asp Ala Asp 
        35                  40                  45              


Trp Asp Asp Leu Trp Asp Gln Phe Asp Glu Arg Arg Tyr Leu Asn Ala 
    50                  55                  60                  


Lys Lys Trp Arg Val Gly Asp Asp Pro Tyr Lys Leu Tyr Ala Phe Asn 
65                  70                  75                  80  


Gln Arg Glu Ser Glu Arg Ile Ser Ser Asn Arg Ala Ile Pro Asp Thr 
                85                  90                  95      


Arg His Leu Arg Cys Thr Leu Leu Val Tyr Cys Thr Asp Leu Pro Pro 
            100                 105                 110         


Thr Ser Ile Ile Ile Thr Phe His Asn Glu Ala Arg Ser Thr Leu Leu 
        115                 120                 125             


Arg Thr Ile Arg Ser Val Leu Asn Arg Thr Pro Thr His Leu Ile Arg 
    130                 135                 140                 


Glu Ile Ile Leu Val Asp Asp Phe Ser Asn Asp Pro Asp Asp Cys Lys 
145                 150                 155                 160 


Gln Leu Ile Lys Leu Pro Lys Val Lys Cys Leu Arg Asn Asn Glu Arg 
                165                 170                 175     


Gln Gly Leu Val Arg Ser Arg Ile Arg Gly Ala Asp Ile Ala Gln Gly 
            180                 185                 190         


Thr Thr Leu Thr Phe Leu Asp Ser His Cys Glu Val Asn Arg Asp Trp 
        195                 200                 205             


Leu Gln Pro Leu Leu His Arg Val Lys Glu Asp Tyr Thr Arg Val Val 
    210                 215                 220                 


Cys Pro Val Ile Asp Ile Ile Asn Leu Asp Thr Phe Thr Tyr Ile Glu 
225                 230                 235                 240 


Ser Ala Ser Glu Leu Arg Gly Gly Phe Asp Trp Ser Leu His Phe Gln 
                245                 250                 255     


Trp Glu Gln Leu Ser Pro Glu Gln Lys Ala Arg Arg Leu Asp Pro Thr 
            260                 265                 270         


Glu Pro Ile Arg Thr Pro Ile Ile Ala Gly Gly Leu Phe Val Ile Asp 
        275                 280                 285             


Lys Ala Trp Phe Asp Tyr Leu Gly Lys Tyr Asp Met Asp Met Asp Ile 
    290                 295                 300                 


Trp Gly Gly Glu Asn Phe Glu Ile Ser Phe Arg Val Trp Met Cys Gly 
305                 310                 315                 320 


Gly Ser Leu Glu Ile Val Pro Cys Ser Arg Val Gly His Val Phe Arg 
                325                 330                 335     


Lys Lys His Pro Tyr Val Phe Pro Asp Gly Asn Ala Asn Thr Tyr Ile 
            340                 345                 350         


Lys Asn Thr Lys Arg Thr Ala Glu Val Trp Met Asp Glu Tyr Lys Gln 
        355                 360                 365             


Tyr Tyr Tyr Ala Ala Arg Pro Phe Ala Leu Glu Arg Pro Phe Gly Asn 
    370                 375                 380                 


Val Glu Ser Arg Leu Asp Leu Arg Lys Asn Leu Arg Cys Gln Ser Phe 
385                 390                 395                 400 


Lys Trp Tyr Leu Glu Asn Ile Tyr Pro Glu Leu Ser Ile Pro Lys Glu 
                405                 410                 415     


Ser Ser Ile Gln Lys Gly Asn Ile Arg Gln Arg Gln Lys Cys Leu Glu 
            420                 425                 430         


Ser Gln Arg Gln Asn Asn Gln Glu Thr Pro Asn Leu Lys Leu Ser Pro 
        435                 440                 445             


Cys Ala Lys Val Lys Gly Glu Asp Ala Lys Ser Gln Val Trp Ala Phe 
    450                 455                 460                 


Thr Tyr Thr Gln Gln Ile Leu Gln Glu Glu Leu Cys Leu Ser Val Ile 
465                 470                 475                 480 


Thr Leu Phe Pro Gly Ala Pro Val Val Leu Val Leu Cys Lys Asn Gly 
                485                 490                 495     


Asp Asp Arg Gln Gln Trp Thr Lys Thr Gly Ser His Ile Glu His Ile 
            500                 505                 510         


Ala Ser His Leu Cys Leu Asp Thr Asp Met Phe Gly Asp Gly Thr Glu 
        515                 520                 525             


Asn Gly Lys Glu Ile Val Val Asn Pro Cys Glu Ser Ser Leu Met Ser 
    530                 535                 540                 


Gln His Trp Asp Met Val Ser Ser 
545                 550         


<210>  5051
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  5051

Met His Asn Pro Asp Gly Ser Ala Ser Pro Thr Ala Asp Pro Gly Ser 
1               5                   10                  15      


Glu Leu Gln Thr Leu Gly Gln Ala Ala Arg Arg Pro Pro Pro Pro Arg 
            20                  25                  30          


Ala Gly His Asp Ala Pro Arg Arg Thr Arg Pro Ser Ala Arg Lys Pro 
        35                  40                  45              


Leu Ser Cys Phe Ser Arg Arg Pro Met Pro Thr Arg Glu Pro Pro Lys 
    50                  55                  60                  


Thr Arg Gly Ser Arg Gly His Leu His Thr His Pro Pro Gly Pro Gly 
65                  70                  75                  80  


Pro Pro Leu Gln Gly Leu Ala Pro Arg Gly Leu Lys Thr Ser Ala Pro 
                85                  90                  95      


Arg Pro Pro Cys Gln Pro Gln Pro Gly Pro His Lys Ala Lys Thr Lys 
            100                 105                 110         


Lys Ile Val Phe Glu Asp Glu Leu Leu Ser Gln Ala Leu Leu Gly Ala 
        115                 120                 125             


Lys Lys Pro Ile Gly Ala Ile Pro Lys Gly His Lys Pro Arg Pro His 
    130                 135                 140                 


Pro Val Pro Asp Tyr Glu Leu Lys Tyr Pro Pro Val Ser Ser Glu Arg 
145                 150                 155                 160 


Glu Arg Ser Arg Tyr Val Ala Val Phe Gln Asp Gln Tyr Gly Glu Phe 
                165                 170                 175     


Leu Glu Leu Gln His Glu Val Gly Cys Ala Gln Ala Lys Leu Arg Gln 
            180                 185                 190         


Leu Glu Ala Leu Leu Ser Ser Leu Pro Pro Pro Gln Ser Gln Lys Glu 
        195                 200                 205             


Ala Gln Val Ala Ala Arg Val Trp Arg Glu Phe Glu Met Lys Arg Met 
    210                 215                 220                 


Asp Pro Gly Phe Leu Asp Lys Gln Ala Arg Cys His Tyr Leu Lys Gly 
225                 230                 235                 240 


Lys Leu Arg His Leu Lys Thr Gln Ile Gln Lys Phe Asp Asp Gln Gly 
                245                 250                 255     


Asp Ser Glu Gly Ser Val Tyr Phe 
            260                 


<210>  5052
<211>  4981
<212>  PRT
<213>  Homo sapiens

<400>  5052

Met Asp Leu Ala Pro Asp Arg Ala Thr Gly Arg Pro Trp Leu Pro Leu 
1               5                   10                  15      


His Thr Leu Ser Val Ser Gln Leu Leu Arg Val Phe Trp Leu Leu Ser 
            20                  25                  30          


Leu Leu Pro Gly Gln Ala Trp Val His Gly Ala Glu Pro Arg Gln Val 
        35                  40                  45              


Phe Gln Val Leu Glu Glu Gln Pro Pro Gly Thr Leu Val Gly Thr Ile 
    50                  55                  60                  


Gln Thr Arg Pro Gly Phe Thr Tyr Arg Leu Ser Glu Ser His Ala Leu 
65                  70                  75                  80  


Phe Ala Ile Asn Ser Ser Thr Gly Ala Leu Tyr Thr Thr Ser Thr Ile 
                85                  90                  95      


Asp Arg Glu Ser Leu Pro Ser Asp Val Ile Asn Leu Val Val Leu Ser 
            100                 105                 110         


Ser Ala Pro Thr Tyr Pro Thr Glu Val Arg Val Leu Val Arg Asp Leu 
        115                 120                 125             


Asn Asp Asn Ala Pro Val Phe Pro Asp Pro Ser Ile Val Val Thr Phe 
    130                 135                 140                 


Lys Glu Asp Ser Ser Ser Gly Arg Gln Val Ile Leu Asp Thr Ala Thr 
145                 150                 155                 160 


Asp Ser Asp Ile Gly Ser Asn Gly Val Asp His Arg Ser Tyr Arg Ile 
                165                 170                 175     


Ile Arg Gly Asn Glu Ala Gly Arg Phe Arg Leu Asp Ile Thr Leu Asn 
            180                 185                 190         


Pro Ser Gly Glu Gly Ala Phe Leu His Leu Val Ser Lys Gly Gly Leu 
        195                 200                 205             


Asp Arg Glu Val Thr Pro Gln Tyr Gln Leu Leu Val Glu Val Glu Asp 
    210                 215                 220                 


Lys Gly Glu Pro Lys Arg Arg Gly Tyr Leu Gln Val Asn Val Thr Val 
225                 230                 235                 240 


Gln Asp Ile Asn Asp Asn Pro Pro Val Phe Gly Ser Ser His Tyr Gln 
                245                 250                 255     


Ala Gly Val Pro Glu Asp Ala Val Val Gly Ser Ser Val Leu Gln Val 
            260                 265                 270         


Ala Ala Ala Asp Ala Asp Glu Gly Thr Asn Ala Asp Ile Arg Tyr Arg 
        275                 280                 285             


Leu Gln Asp Glu Gly Thr Pro Phe Gln Met Asp Pro Glu Thr Gly Leu 
    290                 295                 300                 


Ile Thr Val Arg Glu Pro Leu Asp Phe Glu Ala Arg Arg Gln Tyr Ser 
305                 310                 315                 320 


Leu Thr Val Gln Ala Met Asp Arg Gly Val Pro Ser Leu Thr Gly Arg 
                325                 330                 335     


Ala Glu Ala Leu Ile Gln Leu Leu Asp Val Asn Asp Asn Asp Pro Val 
            340                 345                 350         


Val Lys Phe Arg Tyr Phe Pro Ala Thr Ser Arg Tyr Ala Ser Val Asp 
        355                 360                 365             


Glu Asn Ala Gln Val Gly Thr Val Val Ala Leu Leu Thr Val Thr Asp 
    370                 375                 380                 


Ala Asp Ser Pro Ala Ala Asn Gly Asn Ile Ser Val Gln Ile Leu Gly 
385                 390                 395                 400 


Gly Asn Glu Gln Arg His Phe Glu Val Gln Ser Ser Lys Val Pro Asn 
                405                 410                 415     


Leu Ser Leu Ile Lys Val Ala Ser Ala Leu Asp Arg Glu Arg Ile Pro 
            420                 425                 430         


Ser Tyr Asn Leu Thr Val Ser Val Ser Asp Asn Tyr Gly Ala Pro Pro 
        435                 440                 445             


Gly Ala Ala Val Gln Ala Arg Ser Ser Val Ala Ser Leu Val Ile Phe 
    450                 455                 460                 


Val Asn Asp Ile Asn Asp His Pro Pro Val Phe Ser Gln Gln Val Tyr 
465                 470                 475                 480 


Arg Val Asn Leu Ser Glu Glu Ala Pro Pro Gly Ser Tyr Val Ser Gly 
                485                 490                 495     


Ile Ser Ala Thr Asp Gly Asp Ser Gly Leu Asn Ala Asn Leu Arg Tyr 
            500                 505                 510         


Ser Ile Val Ser Gly Asn Gly Leu Gly Trp Phe His Ile Ser Glu His 
        515                 520                 525             


Ser Gly Leu Val Thr Thr Gly Ser Ser Gly Gly Leu Asp Arg Glu Leu 
    530                 535                 540                 


Ala Ser Gln Ile Val Leu Asn Ile Ser Ala Arg Asp Gln Gly Val His 
545                 550                 555                 560 


Pro Lys Val Ser Tyr Ala Gln Leu Val Val Thr Leu Leu Asp Val Asn 
                565                 570                 575     


Asp Glu Lys Pro Val Phe Ser Gln Pro Glu Gly Tyr Asp Val Ser Val 
            580                 585                 590         


Val Glu Asn Ala Pro Thr Gly Thr Glu Leu Leu Met Leu Arg Ala Thr 
        595                 600                 605             


Asp Gly Asp Leu Gly Asp Asn Gly Thr Val Arg Phe Ser Leu Gln Glu 
    610                 615                 620                 


Ala Glu Thr Asp Arg Arg Ser Phe Arg Leu Asp Pro Val Ser Gly Arg 
625                 630                 635                 640 


Leu Ser Thr Ile Ser Ser Leu Asp Arg Glu Glu Gln Ala Phe Tyr Ser 
                645                 650                 655     


Leu Leu Val Leu Ala Thr Asp Leu Gly Ser Pro Pro Gln Ser Ser Met 
            660                 665                 670         


Ala Arg Ile Asn Val Ser Leu Leu Asp Ile Asn Asp Asn Ser Pro Val 
        675                 680                 685             


Phe Tyr Pro Val Gln Tyr Phe Ala His Ile Lys Glu Asn Glu Pro Gly 
    690                 695                 700                 


Gly Ser Tyr Ile Thr Thr Val Ser Ala Thr Asp Pro Asp Leu Gly Thr 
705                 710                 715                 720 


Asn Gly Thr Val Lys Tyr Ser Ile Ser Ala Gly Asp Arg Ser Arg Phe 
                725                 730                 735     


Gln Val Asn Ala Gln Ser Gly Val Ile Ser Thr Arg Met Ala Leu Asp 
            740                 745                 750         


Arg Glu Glu Lys Thr Ala Tyr Gln Leu Gln Ile Val Ala Thr Asp Gly 
        755                 760                 765             


Gly Asn Leu Gln Ser Pro Asn Gln Ala Ile Val Thr Ile Thr Val Leu 
    770                 775                 780                 


Asp Thr Gln Asp Asn Pro Pro Val Phe Ser Gln Val Ala Tyr Ser Phe 
785                 790                 795                 800 


Val Val Phe Glu Asn Val Ala Leu Gly Tyr His Val Gly Ser Val Ser 
                805                 810                 815     


Ala Ser Thr Met Asp Leu Asn Ser Asn Ile Ser Tyr Leu Ile Thr Thr 
            820                 825                 830         


Gly Asp Gln Lys Gly Met Phe Ala Ile Asn Gln Val Thr Gly Gln Leu 
        835                 840                 845             


Thr Thr Ala Asn Val Ile Asp Arg Glu Glu Gln Ser Phe Tyr Gln Leu 
    850                 855                 860                 


Lys Val Val Ala Ser Gly Gly Thr Val Thr Gly Asp Thr Met Val Asn 
865                 870                 875                 880 


Ile Thr Val Lys Asp Leu Asn Asp Asn Ser Pro His Phe Leu Gln Ala 
                885                 890                 895     


Ile Glu Ser Val Asn Val Val Glu Asn Trp Gln Ala Gly His Ser Ile 
            900                 905                 910         


Phe Gln Ala Lys Ala Val Asp Pro Asp Glu Gly Val Asn Gly Met Val 
        915                 920                 925             


Leu Tyr Ser Leu Lys Gln Asn Pro Lys Asn Leu Phe Ala Ile Asn Glu 
    930                 935                 940                 


Lys Asn Gly Thr Ile Ser Leu Leu Gly Pro Leu Asp Val His Ala Gly 
945                 950                 955                 960 


Ser Tyr Gln Ile Glu Ile Leu Ala Ser Asp Met Gly Val Pro Gln Leu 
                965                 970                 975     


Ser Ser Ser Val Ile Leu Thr Val Tyr Val His Asp Val Asn Asp Asn 
            980                 985                 990         


Ser Pro Val Phe Asp Gln Leu Ser  Tyr Glu Val Thr Leu  Ser Glu Ser 
        995                 1000                 1005             


Glu Pro  Val Asn Ser Arg Phe  Phe Lys Val Gln Ala  Ser Asp Lys 
    1010                 1015                 1020             


Asp Ser  Gly Ala Asn Gly Glu  Ile Ala Tyr Thr Ile  Ala Glu Gly 
    1025                 1030                 1035             


Asn Thr  Gly Asp Ala Phe Gly  Ile Phe Pro Asp Gly  Gln Leu Tyr 
    1040                 1045                 1050             


Ile Lys  Ser Glu Leu Asp Arg  Glu Leu Gln Asp Arg  Tyr Val Leu 
    1055                 1060                 1065             


Met Val  Val Ala Ser Asp Arg  Ala Val Glu Pro Leu  Ser Ala Thr 
    1070                 1075                 1080             


Val Asn  Val Thr Val Ile Leu  Glu Asp Val Asn Asp  Asn Arg Pro 
    1085                 1090                 1095             


Leu Phe  Asn Ser Thr Asn Tyr  Thr Phe Tyr Phe Glu  Glu Glu Gln 
    1100                 1105                 1110             


Arg Ala  Gly Ser Phe Val Gly  Lys Val Ser Ala Val  Asp Lys Asp 
    1115                 1120                 1125             


Phe Gly  Pro Asn Gly Glu Val  Arg Tyr Ser Phe Glu  Met Val Gln 
    1130                 1135                 1140             


Pro Asp  Phe Glu Leu His Ala  Ile Ser Gly Glu Ile  Thr Asn Thr 
    1145                 1150                 1155             


His Gln  Phe Asp Arg Glu Ser  Leu Met Arg Arg Arg  Gly Thr Ala 
    1160                 1165                 1170             


Val Phe  Ser Phe Thr Val Ile  Ala Thr Asp Gln Gly  Ile Pro Gln 
    1175                 1180                 1185             


Pro Leu  Lys Asp Gln Ala Thr  Val His Val Tyr Met  Lys Asp Ile 
    1190                 1195                 1200             


Asn Asp  Asn Ala Pro Lys Phe  Leu Lys Asp Phe Tyr  Gln Ala Thr 
    1205                 1210                 1215             


Ile Ser  Glu Ser Ala Ala Asn  Leu Thr Gln Val Leu  Arg Val Ser 
    1220                 1225                 1230             


Ala Ser  Asp Val Asp Glu Gly  Asn Asn Gly Leu Ile  His Tyr Ser 
    1235                 1240                 1245             


Ile Ile  Lys Gly Asn Glu Glu  Arg Gln Phe Ala Ile  Asp Ser Thr 
    1250                 1255                 1260             


Ser Gly  Gln Val Thr Leu Ile  Gly Lys Leu Asp Tyr  Glu Ala Thr 
    1265                 1270                 1275             


Pro Ala  Tyr Ser Leu Val Ile  Gln Ala Val Asp Ser  Gly Thr Ile 
    1280                 1285                 1290             


Pro Leu  Asn Ser Thr Cys Thr  Leu Asn Ile Asp Ile  Leu Asp Glu 
    1295                 1300                 1305             


Asn Asp  Asn Thr Pro Ser Phe  Pro Lys Ser Thr Leu  Phe Val Asp 
    1310                 1315                 1320             


Val Leu  Glu Asn Met Arg Ile  Gly Glu Leu Val Ser  Ser Val Thr 
    1325                 1330                 1335             


Ala Thr  Asp Ser Asp Ser Gly  Asp Asn Ala Asp Leu  Tyr Tyr Ser 
    1340                 1345                 1350             


Ile Thr  Gly Thr Asn Asn His  Gly Thr Phe Ser Ile  Ser Pro Asn 
    1355                 1360                 1365             


Thr Gly  Ser Ile Phe Leu Ala  Lys Lys Leu Asp Phe  Glu Thr Gln 
    1370                 1375                 1380             


Ser Leu  Tyr Lys Leu Asn Ile  Thr Ala Lys Asp Gln  Gly Arg Pro 
    1385                 1390                 1395             


Pro Arg  Ser Ser Thr Met Ser  Val Val Ile His Val  Arg Asp Phe 
    1400                 1405                 1410             


Asn Asp  Asn Pro Pro Ser Phe  Pro Pro Gly Asp Ile  Phe Lys Ser 
    1415                 1420                 1425             


Ile Val  Glu Asn Ile Pro Ile  Gly Thr Ser Val Ile  Ser Val Thr 
    1430                 1435                 1440             


Ala His  Asp Pro Asp Ala Asp  Ile Asn Gly Gln Leu  Ser Tyr Thr 
    1445                 1450                 1455             


Ile Ile  Gln Gln Met Pro Arg  Gly Asn His Phe Thr  Ile Asp Glu 
    1460                 1465                 1470             


Val Lys  Gly Thr Ile Tyr Thr  Asn Ala Glu Ile Asp  Arg Glu Phe 
    1475                 1480                 1485             


Ala Asn  Leu Phe Glu Leu Thr  Val Lys Ala Asn Asp  Gln Ala Val 
    1490                 1495                 1500             


Pro Ile  Glu Thr Arg Arg Tyr  Ala Leu Lys Asn Val  Thr Ile Leu 
    1505                 1510                 1515             


Val Thr  Asp Leu Asn Asp Asn  Val Pro Met Phe Ile  Ser Gln Asn 
    1520                 1525                 1530             


Ala Leu  Ala Ala Asp Pro Ser  Ala Val Ile Gly Ser  Val Leu Thr 
    1535                 1540                 1545             


Thr Ile  Met Ala Ala Asp Pro  Asp Glu Gly Ala Asn  Gly Glu Ile 
    1550                 1555                 1560             


Glu Tyr  Glu Ile Ile Asn Gly  Asp Thr Asp Thr Phe  Ile Val Asp 
    1565                 1570                 1575             


Arg Tyr  Ser Gly Asp Leu Arg  Val Ala Ser Ala Leu  Val Pro Ser 
    1580                 1585                 1590             


Gln Leu  Ile Tyr Asn Leu Ile  Val Ser Ala Thr Asp  Leu Gly Pro 
    1595                 1600                 1605             


Glu Arg  Arg Lys Ser Thr Thr  Glu Leu Thr Ile Ile  Leu Gln Gly 
    1610                 1615                 1620             


Leu Asp  Gly Pro Val Phe Thr  Gln Pro Lys Tyr Ile  Thr Ile Leu 
    1625                 1630                 1635             


Lys Glu  Gly Glu Pro Ile Gly  Thr Asn Val Ile Ser  Ile Glu Ala 
    1640                 1645                 1650             


Ala Ser  Pro Arg Gly Ser Glu  Ala Pro Val Glu Tyr  Tyr Ile Val 
    1655                 1660                 1665             


Ser Val  Arg Cys Glu Glu Lys  Thr Val Gly Arg Leu  Phe Thr Ile 
    1670                 1675                 1680             


Gly Arg  His Thr Gly Ile Ile  Gln Thr Ala Ala Ile  Leu Asp Arg 
    1685                 1690                 1695             


Glu Gln  Gly Ala Cys Leu Tyr  Leu Val Asp Val Tyr  Ala Ile Glu 
    1700                 1705                 1710             


Lys Ser  Thr Ala Phe Pro Arg  Thr Gln Arg Ala Glu  Val Glu Ile 
    1715                 1720                 1725             


Thr Leu  Gln Asp Ile Asn Asp  Asn Pro Pro Val Phe  Pro Thr Asp 
    1730                 1735                 1740             


Met Leu  Asp Leu Thr Val Glu  Glu Asn Ile Gly Asp  Gly Ser Lys 
    1745                 1750                 1755             


Ile Met  Gln Leu Thr Ala Met  Asp Ala Asp Glu Gly  Ala Asn Ala 
    1760                 1765                 1770             


Leu Val  Thr Tyr Thr Ile Ile  Ser Gly Ala Asp Asp  Ser Phe Arg 
    1775                 1780                 1785             


Ile Asp  Pro Glu Ser Gly Asp  Leu Ile Ala Thr Arg  Arg Leu Asp 
    1790                 1795                 1800             


Arg Glu  Arg Arg Ser Lys Tyr  Ser Leu Leu Val Arg  Ala Asp Asp 
    1805                 1810                 1815             


Gly Leu  Gln Ser Ser Asp Met  Arg Ile Asn Ile Thr  Val Ser Asp 
    1820                 1825                 1830             


Val Asn  Asp His Thr Pro Lys  Phe Ser Arg Pro Val  Tyr Ser Phe 
    1835                 1840                 1845             


Asp Ile  Pro Glu Asp Thr Ile  Pro Gly Ser Leu Val  Ala Ala Ile 
    1850                 1855                 1860             


Leu Ala  Thr Asp Asp Asp Ser  Gly Val Asn Gly Glu  Ile Thr Tyr 
    1865                 1870                 1875             


Ile Val  Asn Glu Asp Asp Glu  Asp Gly Ile Phe Phe  Leu Asn Pro 
    1880                 1885                 1890             


Ile Thr  Gly Val Phe Asn Leu  Thr Arg Leu Leu Asp  Tyr Glu Val 
    1895                 1900                 1905             


Gln Gln  Tyr Tyr Ile Leu Thr  Val Arg Ala Glu Asp  Gly Gly Gly 
    1910                 1915                 1920             


Gln Phe  Thr Thr Ile Arg Val  Tyr Phe Asn Ile Leu  Asp Val Asn 
    1925                 1930                 1935             


Asp Asn  Pro Pro Ile Phe Ser  Leu Asn Ser Tyr Ser  Thr Ser Leu 
    1940                 1945                 1950             


Met Glu  Asn Leu Pro Val Gly  Ser Thr Val Leu Val  Phe Asn Val 
    1955                 1960                 1965             


Thr Asp  Ala Asp Asp Gly Ile  Asn Ser Gln Leu Thr  Tyr Ser Ile 
    1970                 1975                 1980             


Ala Ser  Gly Asp Ser Leu Gly  Gln Phe Thr Val Asp  Lys Asn Gly 
    1985                 1990                 1995             


Val Leu  Lys Val Leu Lys Ala  Leu Asp Arg Glu Ser  Gln Ser Phe 
    2000                 2005                 2010             


Tyr Asn  Leu Val Val Gln Val  His Asp Leu Pro Gln  Ile Pro Ala 
    2015                 2020                 2025             


Ser Arg  Phe Thr Ser Thr Ala  Gln Val Ser Ile Ile  Leu Leu Asp 
    2030                 2035                 2040             


Val Asn  Asp Asn Pro Pro Thr  Phe Leu Ser Pro Lys  Leu Thr Tyr 
    2045                 2050                 2055             


Ile Pro  Glu Asn Thr Pro Ile  Asp Thr Val Val Phe  Lys Ala Gln 
    2060                 2065                 2070             


Ala Thr  Asp Pro Asp Ser Gly  Pro Asn Ser Tyr Ile  Glu Tyr Thr 
    2075                 2080                 2085             


Leu Leu  Asn Pro Leu Gly Asn  Lys Phe Ser Ile Gly  Thr Ile Asp 
    2090                 2095                 2100             


Gly Glu  Val Arg Leu Thr Gly  Glu Leu Asp Arg Glu  Glu Val Ser 
    2105                 2110                 2115             


Asn Tyr  Thr Leu Thr Val Val  Ala Thr Asp Lys Gly  Gln Pro Ser 
    2120                 2125                 2130             


Leu Ser  Ser Ser Thr Glu Val  Val Val Met Val Leu  Asp Ile Asn 
    2135                 2140                 2145             


Asp Asn  Asn Pro Ile Phe Ala  Gln Ala Leu Tyr Lys  Val Glu Ile 
    2150                 2155                 2160             


Asn Glu  Asn Thr Leu Thr Gly  Thr Asp Ile Ile Gln  Val Phe Ala 
    2165                 2170                 2175             


Ala Asp  Gly Asp Glu Gly Thr  Asn Gly Gln Val Arg  Tyr Gly Ile 
    2180                 2185                 2190             


Val Asn  Gly Asn Thr Asn Gln  Glu Phe Arg Ile Asp  Ser Val Thr 
    2195                 2200                 2205             


Gly Ala  Ile Thr Val Ala Lys  Pro Leu Asp Arg Glu  Lys Thr Pro 
    2210                 2215                 2220             


Thr Tyr  His Leu Thr Val Gln  Ala Thr Asp Arg Gly  Ser Thr Pro 
    2225                 2230                 2235             


Arg Thr  Asp Thr Ser Thr Val  Ser Ile Val Leu Leu  Asp Ile Asn 
    2240                 2245                 2250             


Asp Phe  Val Pro Val Phe Glu  Leu Ser Pro Tyr Ser  Val Asn Val 
    2255                 2260                 2265             


Pro Glu  Asn Leu Gly Thr Leu  Pro Arg Thr Ile Leu  Gln Val Val 
    2270                 2275                 2280             


Ala Arg  Asp Asp Asp Arg Gly  Ser Asn Ser Lys Leu  Ser Tyr Val 
    2285                 2290                 2295             


Leu Phe  Gly Gly Asn Glu Asp  Asn Ala Phe Thr Leu  Ser Ala Ser 
    2300                 2305                 2310             


Gly Glu  Leu Gly Val Thr Gln  Ser Leu Asp Arg Glu  Thr Lys Glu 
    2315                 2320                 2325             


Arg Phe  Val Leu Met Ile Thr  Ala Thr Asp Ser Gly  Ser Pro Ala 
    2330                 2335                 2340             


Leu Thr  Gly Thr Gly Thr Ile  Asn Val Ile Val Asp  Asp Val Asn 
    2345                 2350                 2355             


Asp Asn  Val Pro Thr Phe Ala  Ser Lys Ala Tyr Phe  Thr Thr Ile 
    2360                 2365                 2370             


Pro Glu  Asp Ala Pro Thr Gly  Thr Asp Val Leu Leu  Val Asn Ala 
    2375                 2380                 2385             


Ser Asp  Ala Asp Ala Ser Lys  Asn Ala Val Ile Arg  Ile Ile Gly 
    2390                 2395                 2400             


Gly Asn  Ser Gln Phe Thr Ile  Asn Pro Ser Thr Gly  Gln Ile Ile 
    2405                 2410                 2415             


Thr Ser  Ala Leu Leu Asp Arg  Glu Thr Lys Asp Asn  Tyr Thr Leu 
    2420                 2425                 2430             


Val Val  Val Cys Ser Asp Ala  Gly Ser Pro Glu Pro  Leu Ser Ser 
    2435                 2440                 2445             


Ser Thr  Ser Val Leu Val Thr  Val Thr Asp Val Asn  Asp Asn Pro 
    2450                 2455                 2460             


Pro Arg  Phe Gln His His Pro  Tyr Val Thr His Ile  Pro Ser Pro 
    2465                 2470                 2475             


Thr Leu  Pro Gly Ser Phe Val  Phe Ala Val Thr Val  Thr Asp Ala 
    2480                 2485                 2490             


Asp Ile  Gly Pro Asn Ser Glu  Leu His Tyr Ser Leu  Ser Gly Arg 
    2495                 2500                 2505             


Asn Ser  Glu Lys Phe His Ile  Asp Pro Leu Arg Gly  Ala Ile Met 
    2510                 2515                 2520             


Ala Ala  Gly Pro Leu Asn Gly  Ala Ser Glu Val Thr  Phe Ser Val 
    2525                 2530                 2535             


His Val  Lys Asp Gly Gly Ser  Phe Pro Lys Thr Asp  Ser Thr Thr 
    2540                 2545                 2550             


Val Thr  Val Arg Phe Val Asn  Lys Ala Asp Phe Pro  Lys Val Arg 
    2555                 2560                 2565             


Ala Lys  Glu Gln Thr Phe Met  Phe Pro Glu Asn Gln  Pro Val Ser 
    2570                 2575                 2580             


Ser Leu  Val Thr Thr Ile Thr  Gly Ser Ser Leu Arg  Gly Glu Pro 
    2585                 2590                 2595             


Met Ser  Tyr Tyr Ile Ala Ser  Gly Asn Leu Gly Asn  Thr Phe Gln 
    2600                 2605                 2610             


Ile Asp  Gln Leu Thr Gly Gln  Val Ser Ile Ser Gln  Pro Leu Asp 
    2615                 2620                 2625             


Phe Glu  Lys Ile Gln Lys Tyr  Val Val Trp Ile Glu  Ala Arg Asp 
    2630                 2635                 2640             


Gly Gly  Phe Pro Pro Phe Ser  Ser Tyr Glu Lys Leu  Asp Ile Thr 
    2645                 2650                 2655             


Val Leu  Asp Val Asn Asp Asn  Ala Pro Ile Phe Lys  Glu Asp Pro 
    2660                 2665                 2670             


Phe Ile  Ser Glu Ile Leu Glu  Asn Leu Ser Pro Arg  Lys Ile Leu 
    2675                 2680                 2685             


Thr Val  Ser Ala Met Asp Lys  Asp Ser Gly Pro Asn  Gly Gln Leu 
    2690                 2695                 2700             


Asp Tyr  Glu Ile Val Asn Gly  Asn Met Glu Asn Ser  Phe Ser Ile 
    2705                 2710                 2715             


Asn His  Ala Thr Gly Glu Ile  Arg Ser Val Arg Pro  Leu Asp Arg 
    2720                 2725                 2730             


Glu Lys  Val Ser His Tyr Val  Leu Thr Ile Lys Ser  Ser Asp Lys 
    2735                 2740                 2745             


Gly Ser  Pro Ser Gln Ser Thr  Ser Val Lys Val Met  Ile Asn Ile 
    2750                 2755                 2760             


Leu Asp  Glu Asn Asp Asn Ala  Pro Arg Phe Ser Gln  Ile Phe Ser 
    2765                 2770                 2775             


Ala His  Val Pro Glu Asn Ser  Pro Leu Gly Tyr Thr  Val Thr Arg 
    2780                 2785                 2790             


Val Thr  Thr Ser Asp Glu Asp  Ile Gly Ile Asn Ala  Ile Ser Arg 
    2795                 2800                 2805             


Tyr Ser  Ile Met Asp Ala Ser  Leu Pro Phe Thr Ile  Asn Pro Ser 
    2810                 2815                 2820             


Thr Gly  Asp Ile Val Ile Ser  Arg Pro Leu Asn Arg  Glu Asp Thr 
    2825                 2830                 2835             


Asp Arg  Tyr Arg Ile Arg Val  Ser Ala His Asp Ser  Gly Trp Thr 
    2840                 2845                 2850             


Val Ser  Thr Asp Val Thr Ile  Phe Val Thr Asp Ile  Asn Asp Asn 
    2855                 2860                 2865             


Ala Pro  Arg Phe Ser Arg Thr  Ser Tyr Tyr Leu Asp  Cys Pro Glu 
    2870                 2875                 2880             


Leu Thr  Glu Ile Gly Ser Lys  Val Thr Gln Val Phe  Ala Thr Asp 
    2885                 2890                 2895             


Pro Asp  Glu Gly Ser Asn Gly  Gln Val Phe Tyr Phe  Ile Lys Ser 
    2900                 2905                 2910             


Gln Ser  Glu Tyr Phe Arg Ile  Asn Ala Thr Thr Gly  Glu Ile Phe 
    2915                 2920                 2925             


Asn Lys  Gln Ile Leu Lys Tyr  Gln Asn Val Thr Gly  Phe Ser Asn 
    2930                 2935                 2940             


Val Asn  Ile Asn Arg His Ser  Phe Ile Val Thr Ser  Ser Asp Arg 
    2945                 2950                 2955             


Gly Lys  Pro Ser Leu Ile Ser  Glu Thr Thr Val Thr  Ile Asn Ile 
    2960                 2965                 2970             


Val Asp  Ser Asn Asp Asn Ala  Pro Gln Phe Leu Lys  Ser Lys Tyr 
    2975                 2980                 2985             


Phe Thr  Pro Val Thr Lys Asn  Val Lys Val Gly Thr  Lys Leu Ile 
    2990                 2995                 3000             


Arg Val  Thr Ala Ile Asp Asp  Lys Asp Phe Gly Leu  Asn Ser Glu 
    3005                 3010                 3015             


Val Glu  Tyr Phe Ile Ser Asn  Asp Asn His Leu Gly  Lys Phe Lys 
    3020                 3025                 3030             


Leu Asp  Asn Asp Thr Gly Trp  Ile Ser Val Ala Ser  Ser Leu Ile 
    3035                 3040                 3045             


Ser Asp  Leu Asn Gln Asn Phe  Phe Ile Thr Val Thr  Ala Lys Asp 
    3050                 3055                 3060             


Lys Gly  Asn Pro Pro Leu Ser  Ser Gln Ala Thr Val  His Ile Thr 
    3065                 3070                 3075             


Val Thr  Glu Glu Asn Tyr His  Thr Pro Glu Phe Ser  Gln Ser His 
    3080                 3085                 3090             


Met Ser  Ala Thr Ile Pro Glu  Ser His Ser Ile Gly  Ser Ile Val 
    3095                 3100                 3105             


Arg Thr  Val Ser Ala Arg Asp  Arg Asp Ala Ala Met  Asn Gly Leu 
    3110                 3115                 3120             


Ile Lys  Tyr Ser Ile Ser Ser  Gly Asn Glu Glu Gly  Ile Phe Ala 
    3125                 3130                 3135             


Ile Asn  Ser Ser Thr Gly Ile  Leu Thr Leu Ala Lys  Ala Leu Asp 
    3140                 3145                 3150             


Tyr Glu  Leu Cys Gln Lys His  Glu Met Thr Ile Ser  Ala Ile Asp 
    3155                 3160                 3165             


Gly Gly  Trp Val Ala Arg Thr  Gly Tyr Cys Ser Val  Thr Val Asn 
    3170                 3175                 3180             


Val Ile  Asp Val Asn Asp Asn  Ser Pro Val Phe Leu  Ser Asp Asp 
    3185                 3190                 3195             


Tyr Phe  Pro Thr Val Leu Glu  Asn Ala Pro Ser Gly  Thr Thr Val 
    3200                 3205                 3210             


Ile His  Leu Asn Ala Thr Asp  Ala Asp Ser Gly Thr  Asn Ala Val 
    3215                 3220                 3225             


Ile Ala  Tyr Thr Val Gln Ser  Ser Asp Ser Asp Leu  Phe Val Ile 
    3230                 3235                 3240             


Asp Pro  Asn Thr Gly Val Ile  Thr Thr Gln Gly Phe  Leu Asp Phe 
    3245                 3250                 3255             


Glu Thr  Lys Gln Ser Tyr His  Leu Thr Val Lys Ala  Phe Asn Val 
    3260                 3265                 3270             


Pro Asp  Glu Glu Arg Cys Ser  Phe Ala Thr Val Asn  Ile Gln Leu 
    3275                 3280                 3285             


Lys Gly  Thr Asn Glu Tyr Val  Pro Arg Phe Val Ser  Lys Leu Tyr 
    3290                 3295                 3300             


Tyr Phe  Glu Ile Ser Glu Ala  Ala Pro Lys Gly Thr  Ile Val Gly 
    3305                 3310                 3315             


Glu Val  Phe Ala Ser Asp Arg  Asp Leu Gly Thr Asp  Gly Glu Val 
    3320                 3325                 3330             


His Tyr  Leu Ile Phe Gly Asn  Ser Arg Lys Lys Gly  Phe Gln Ile 
    3335                 3340                 3345             


Asn Lys  Lys Thr Gly Gln Ile  Tyr Val Ser Gly Ile  Leu Asp Arg 
    3350                 3355                 3360             


Glu Lys  Glu Glu Arg Val Ser  Leu Lys Val Leu Ala  Lys Asn Phe 
    3365                 3370                 3375             


Gly Ser  Ile Arg Gly Ala Asp  Ile Asp Glu Val Thr  Val Asn Val 
    3380                 3385                 3390             


Thr Val  Leu Asp Ala Asn Asp  Pro Pro Ile Phe Thr  Leu Asn Ile 
    3395                 3400                 3405             


Tyr Ser  Val Gln Ile Ser Glu  Gly Val Pro Ile Gly  Thr His Val 
    3410                 3415                 3420             


Thr Phe  Val Ser Ala Phe Asp  Ser Asp Ser Ile Pro  Ser Trp Ser 
    3425                 3430                 3435             


Arg Phe  Ser Tyr Phe Ile Gly  Ser Gly Asn Glu Asn  Gly Ala Phe 
    3440                 3445                 3450             


Ser Ile  Asn Pro Gln Thr Gly  Gln Ile Thr Val Thr  Ala Glu Leu 
    3455                 3460                 3465             


Asp Arg  Glu Thr Leu Pro Ile  Tyr Asn Leu Ser Val  Leu Ala Val 
    3470                 3475                 3480             


Asp Ser  Gly Thr Pro Ser Ala  Thr Gly Ser Ala Ser  Leu Leu Val 
    3485                 3490                 3495             


Thr Leu  Glu Asp Ile Asn Asp  Asn Gly Pro Met Leu  Thr Val Ser 
    3500                 3505                 3510             


Glu Gly  Glu Val Met Glu Asn  Lys Arg Pro Gly Thr  Leu Val Met 
    3515                 3520                 3525             


Thr Leu  Gln Ser Thr Asp Pro  Asp Leu Pro Pro Asn  Gln Gly Pro 
    3530                 3535                 3540             


Phe Thr  Tyr Tyr Leu Leu Ser  Thr Gly Pro Ala Thr  Ser Tyr Phe 
    3545                 3550                 3555             


Ser Leu  Ser Thr Ala Gly Val  Leu Ser Thr Thr Arg  Glu Ile Asp 
    3560                 3565                 3570             


Arg Glu  Gln Ile Ala Asp Phe  Tyr Leu Ser Val Val  Thr Lys Asp 
    3575                 3580                 3585             


Ser Gly  Val Pro Gln Met Ser  Ser Thr Gly Thr Val  His Ile Thr 
    3590                 3595                 3600             


Val Ile  Asp Gln Asn Asp Asn  Pro Ser Gln Ser Arg  Thr Val Glu 
    3605                 3610                 3615             


Ile Phe  Val Asn Tyr Tyr Gly  Asn Leu Phe Pro Gly  Gly Ile Leu 
    3620                 3625                 3630             


Gly Ser  Val Lys Pro Gln Asp  Pro Asp Val Leu Asp  Ser Phe His 
    3635                 3640                 3645             


Cys Ser  Leu Thr Ser Gly Val  Thr Ser Leu Phe Ser  Ile Pro Gly 
    3650                 3655                 3660             


Gly Thr  Cys Asp Leu Asn Ser  Gln Pro Arg Ser Thr  Asp Gly Thr 
    3665                 3670                 3675             


Phe Asp  Leu Thr Val Leu Ser  Asn Asp Gly Val His  Ser Thr Val 
    3680                 3685                 3690             


Thr Ser  Asn Ile Arg Val Phe  Phe Ala Gly Phe Ser  Asn Ala Thr 
    3695                 3700                 3705             


Val Asp  Asn Ser Ile Leu Leu  Arg Leu Gly Val Pro  Thr Val Lys 
    3710                 3715                 3720             


Asp Phe  Leu Thr Asn His Tyr  Leu His Phe Leu Arg  Ile Ala Ser 
    3725                 3730                 3735             


Ser Gln  Leu Thr Gly Leu Gly  Thr Ala Val Gln Leu  Tyr Ser Ala 
    3740                 3745                 3750             


Tyr Glu  Glu Asn Asn Arg Thr  Phe Leu Leu Ala Ala  Val Lys Arg 
    3755                 3760                 3765             


Asn His  Asn Gln Tyr Val Asn  Pro Ser Gly Val Ala  Thr Phe Phe 
    3770                 3775                 3780             


Glu Ser  Ile Lys Glu Ile Leu  Leu Arg Gln Ser Gly  Val Lys Val 
    3785                 3790                 3795             


Glu Ser  Val Asp His Asp Ser  Cys Val His Gly Pro  Cys Gln Asn 
    3800                 3805                 3810             


Gly Gly  Ser Cys Leu Arg Arg  Leu Ala Val Ser Ser  Val Leu Lys 
    3815                 3820                 3825             


Ser Arg  Glu Ser Leu Pro Val  Ile Ile Val Ala Asn  Glu Pro Leu 
    3830                 3835                 3840             


Gln Pro  Phe Leu Cys Lys Cys  Leu Pro Gly Tyr Ala  Gly Ser Trp 
    3845                 3850                 3855             


Cys Glu  Ile Asp Ile Asp Glu  Cys Leu Pro Ser Pro  Cys His Ser 
    3860                 3865                 3870             


Gly Gly  Thr Cys His Asn Leu  Val Gly Gly Phe Ser  Cys Ser Cys 
    3875                 3880                 3885             


Pro Asp  Gly Phe Thr Gly Arg  Ala Cys Glu Arg Asp  Ile Asn Glu 
    3890                 3895                 3900             


Cys Leu  Gln Ser Pro Cys Lys  Asn Gly Ala Ile Cys  Gln Asn Phe 
    3905                 3910                 3915             


Pro Gly  Ser Phe Asn Cys Val  Cys Lys Thr Gly Tyr  Thr Gly Lys 
    3920                 3925                 3930             


Met Cys  Glu Ser Ser Val Asn  Tyr Cys Glu Cys Asn  Pro Cys Phe 
    3935                 3940                 3945             


Asn Gly  Gly Ser Cys Gln Ser  Gly Val Asp Ser Tyr  Tyr Cys His 
    3950                 3955                 3960             


Cys Pro  Phe Gly Val Phe Gly  Lys His Cys Glu Leu  Asn Ser Tyr 
    3965                 3970                 3975             


Gly Phe  Glu Glu Leu Ser Tyr  Met Glu Phe Pro Ser  Leu Asp Pro 
    3980                 3985                 3990             


Asn Asn  Asn Tyr Ile Tyr Val  Lys Phe Ala Thr Ile  Lys Ser His 
    3995                 4000                 4005             


Ala Leu  Leu Leu Tyr Asn Tyr  Asp Asn Gln Thr Gly  Asp Arg Ala 
    4010                 4015                 4020             


Glu Phe  Leu Ala Leu Glu Ile  Ala Glu Glu Arg Leu  Arg Phe Ser 
    4025                 4030                 4035             


Tyr Asn  Leu Gly Ser Gly Thr  Tyr Lys Leu Thr Thr  Met Lys Lys 
    4040                 4045                 4050             


Val Ser  Asp Gly His Phe His  Thr Val Ile Ala Arg  Arg Ala Gly 
    4055                 4060                 4065             


Met Ala  Ala Ser Leu Thr Val  Asp Ser Cys Ser Glu  Asn Gln Glu 
    4070                 4075                 4080             


Pro Gly  Tyr Cys Thr Val Ser  Asn Val Ala Val Ser  Asp Asp Trp 
    4085                 4090                 4095             


Thr Leu  Asp Val Gln Pro Asn  Arg Val Thr Val Gly  Gly Ile Arg 
    4100                 4105                 4110             


Ser Leu  Glu Pro Ile Leu Gln  Arg Arg Gly His Val  Glu Ser His 
    4115                 4120                 4125             


Asp Phe  Val Gly Cys Ile Met  Glu Phe Ala Val Asn  Gly Arg Pro 
    4130                 4135                 4140             


Leu Glu  Pro Ser Gln Ala Leu  Ala Ala Gln Gly Ile  Leu Asp Gln 
    4145                 4150                 4155             


Cys Pro  Arg Leu Glu Gly Ala  Cys Thr Arg Ser Pro  Cys Gln His 
    4160                 4165                 4170             


Gly Gly  Thr Cys Met Asp Tyr  Trp Ser Trp Gln Gln  Cys His Cys 
    4175                 4180                 4185             


Lys Glu  Gly Leu Thr Gly Lys  Tyr Cys Glu Lys Ser  Val Thr Pro 
    4190                 4195                 4200             


Asp Thr  Ala Leu Ser Leu Glu  Gly Lys Gly Arg Leu  Asp Tyr His 
    4205                 4210                 4215             


Met Ser  Gln Asn Glu Lys Arg  Glu Tyr Leu Leu Arg  Gln Ser Leu 
    4220                 4225                 4230             


Arg Gly  Ala Met Leu Glu Pro  Phe Gly Val Asn Ser  Leu Glu Val 
    4235                 4240                 4245             


Lys Phe  Arg Thr Arg Ser Glu  Asn Gly Val Leu Ile  His Ile Gln 
    4250                 4255                 4260             


Glu Ser  Ser Asn Tyr Thr Thr  Val Lys Ile Lys Asn  Gly Lys Val 
    4265                 4270                 4275             


Tyr Phe  Thr Ser Asp Ala Gly  Ile Ala Gly Lys Val  Glu Arg Asn 
    4280                 4285                 4290             


Ile Pro  Glu Val Tyr Val Ala  Asp Gly His Trp His  Thr Phe Leu 
    4295                 4300                 4305             


Ile Gly  Lys Asn Gly Thr Ala  Thr Val Leu Ser Val  Asp Arg Ile 
    4310                 4315                 4320             


Tyr Asn  Arg Asp Ile Ile His  Pro Thr Gln Asp Phe  Gly Gly Leu 
    4325                 4330                 4335             


Asp Val  Leu Thr Ile Ser Leu  Gly Gly Ile Pro Pro  Asn Gln Ala 
    4340                 4345                 4350             


His Arg  Asp Ala Gln Thr Ala  Gly Phe Asp Gly Cys  Ile Ala Ser 
    4355                 4360                 4365             


Met Trp  Tyr Gly Gly Glu Ser  Leu Pro Phe Ser Gly  Lys His Ser 
    4370                 4375                 4380             


Leu Ala  Ser Ile Ser Lys Thr  Asp Pro Ser Val Lys  Ile Gly Cys 
    4385                 4390                 4395             


Arg Gly  Pro Asn Ile Cys Ala  Ser Asn Pro Cys Trp  Gly Asp Leu 
    4400                 4405                 4410             


Leu Cys  Ile Asn Gln Trp Tyr  Ala Tyr Arg Cys Val  Pro Pro Gly 
    4415                 4420                 4425             


Asp Cys  Ala Ser His Pro Cys  Gln Asn Gly Gly Ser  Cys Glu Pro 
    4430                 4435                 4440             


Gly Leu  His Ser Gly Phe Thr  Cys Ser Cys Pro Asp  Ser His Thr 
    4445                 4450                 4455             


Gly Arg  Thr Cys Glu Met Val  Val Ala Cys Leu Gly  Val Leu Cys 
    4460                 4465                 4470             


Pro Gln  Gly Lys Val Cys Lys  Ala Gly Ser Pro Ala  Gly His Val 
    4475                 4480                 4485             


Cys Val  Leu Ser Gln Gly Pro  Glu Glu Ile Ser Leu  Pro Leu Trp 
    4490                 4495                 4500             


Ala Val  Pro Ala Ile Val Gly  Ser Cys Ala Thr Val  Leu Ala Leu 
    4505                 4510                 4515             


Leu Val  Leu Ser Leu Ile Leu  Cys Asn Gln Cys Arg  Gly Lys Lys 
    4520                 4525                 4530             


Ala Lys  Asn Pro Lys Glu Glu  Lys Lys Pro Lys Glu  Lys Lys Lys 
    4535                 4540                 4545             


Lys Gly  Ser Glu Asn Val Ala  Phe Asp Asp Pro Asp  Asn Ile Pro 
    4550                 4555                 4560             


Pro Tyr  Gly Asp Asp Met Thr  Val Arg Lys Gln Pro  Glu Gly Asn 
    4565                 4570                 4575             


Pro Lys  Pro Asp Ile Ile Glu  Arg Glu Asn Pro Tyr  Leu Ile Tyr 
    4580                 4585                 4590             


Asp Glu  Thr Asp Ile Pro His  Asn Ser Glu Thr Ile  Pro Ser Ala 
    4595                 4600                 4605             


Pro Leu  Ala Ser Pro Glu Gln  Glu Ile Glu His Tyr  Asp Ile Asp 
    4610                 4615                 4620             


Asn Ala  Ser Ser Ile Ala Pro  Ser Asp Ala Asp Ile  Ile Gln His 
    4625                 4630                 4635             


Tyr Lys  Gln Phe Arg Ser His  Thr Pro Lys Phe Ser  Ile Gln Arg 
    4640                 4645                 4650             


His Ser  Pro Leu Gly Phe Ala  Arg Gln Ser Pro Met  Pro Leu Gly 
    4655                 4660                 4665             


Ala Ser  Ser Leu Thr Tyr Gln  Pro Ser Tyr Gly Gln  Gly Leu Arg 
    4670                 4675                 4680             


Thr Ser  Ser Leu Ser His Ser  Ala Cys Pro Thr Pro  Asn Pro Leu 
    4685                 4690                 4695             


Ser Arg  His Ser Pro Ala Pro  Phe Ser Lys Ser Ser  Thr Phe Tyr 
    4700                 4705                 4710             


Arg Asn  Ser Pro Ala Arg Glu  Leu His Leu Pro Ile  Arg Asp Gly 
    4715                 4720                 4725             


Asn Thr  Leu Glu Met His Gly  Asp Thr Cys Gln Pro  Gly Ile Phe 
    4730                 4735                 4740             


Asn Tyr  Ala Thr Arg Leu Gly  Arg Arg Ser Lys Ser  Pro Gln Ala 
    4745                 4750                 4755             


Met Ala  Ser His Gly Ser Arg  Pro Gly Ser Arg Leu  Lys Gln Pro 
    4760                 4765                 4770             


Ile Gly  Gln Ile Pro Leu Glu  Ser Ser Pro Pro Val  Gly Leu Ser 
    4775                 4780                 4785             


Ile Glu  Glu Val Glu Arg Leu  Asn Thr Pro Arg Pro  Arg Asn Pro 
    4790                 4795                 4800             


Ser Ile  Cys Ser Ala Asp His  Gly Arg Ser Ser Ser  Glu Glu Asp 
    4805                 4810                 4815             


Cys Arg  Arg Pro Leu Ser Arg  Thr Arg Asn Pro Ala  Asp Gly Ile 
    4820                 4825                 4830             


Pro Ala  Pro Glu Ser Ser Ser  Asp Ser Asp Ser His  Glu Ser Phe 
    4835                 4840                 4845             


Thr Cys  Ser Glu Met Glu Tyr  Asp Arg Glu Lys Pro  Met Val Tyr 
    4850                 4855                 4860             


Thr Ser  Arg Met Pro Lys Leu  Ser Gln Val Asn Glu  Ser Asp Ala 
    4865                 4870                 4875             


Asp Asp  Glu Asp Asn Tyr Gly  Ala Arg Leu Lys Pro  Arg Arg Tyr 
    4880                 4885                 4890             


His Gly  Arg Arg Ala Glu Gly  Gly Pro Val Gly Thr  Gln Ala Ala 
    4895                 4900                 4905             


Ala Pro  Gly Thr Ala Asp Asn  Thr Leu Pro Met Lys  Leu Gly Gln 
    4910                 4915                 4920             


Gln Ala  Gly Thr Phe Asn Trp  Asp Asn Leu Leu Asn  Trp Gly Pro 
    4925                 4930                 4935             


Gly Phe  Gly His Tyr Val Asp  Val Phe Lys Asp Leu  Ala Ser Leu 
    4940                 4945                 4950             


Pro Glu  Lys Ala Ala Ala Asn  Glu Glu Gly Lys Ala  Gly Thr Thr 
    4955                 4960                 4965             


Lys Pro  Val Pro Lys Asp Gly  Glu Ala Glu Gln Tyr  Val 
    4970                 4975                 4980     


<210>  5053
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  5053

Met Ala Pro Trp Ala Glu Ala Glu His Ser Ala Leu Asn Pro Leu Arg 
1               5                   10                  15      


Ala Val Trp Leu Thr Leu Thr Ala Ala Phe Leu Leu Thr Leu Leu Leu 
            20                  25                  30          


Gln Leu Leu Pro Pro Gly Leu Leu Pro Gly Cys Ala Ile Phe Gln Asp 
        35                  40                  45              


Leu Ile Arg Tyr Gly Lys Thr Lys Cys Gly Glu Pro Ser Arg Pro Ala 
    50                  55                  60                  


Ala Cys Arg Ala Phe Asp Val Pro Lys Arg Tyr Phe Ser His Phe Tyr 
65                  70                  75                  80  


Ile Ile Ser Val Leu Trp Asn Gly Phe Leu Leu Trp Cys Leu Thr Gln 
                85                  90                  95      


Ser Leu Phe Leu Gly Ala Pro Phe Pro Ser Trp Leu His Gly Leu Leu 
            100                 105                 110         


Arg Ile Leu Gly Ala Ala Gln Phe Gln Gly Gly Glu Leu Ala Leu Ser 
        115                 120                 125             


Ala Phe Leu Val Leu Val Phe Leu Trp Leu His Ser Leu Arg Arg Leu 
    130                 135                 140                 


Phe Glu Cys Leu Tyr Val Ser Val Phe Ser Asn Val Met Ile His Val 
145                 150                 155                 160 


Val Gln Tyr Cys Phe Gly Leu Val Tyr Tyr Val Leu Val Gly Leu Thr 
                165                 170                 175     


Val Leu Ser Gln Val Pro Met Asp Gly Arg Asn Ala Tyr Ile Thr Gly 
            180                 185                 190         


Lys Asn Leu Leu Met Gln Ala Arg Trp Phe His Ile Leu Gly Met Met 
        195                 200                 205             


Met Phe Ile Trp Ser Ser Ala His Gln Tyr Lys Cys His Val Ile Leu 
    210                 215                 220                 


Gly Asn Leu Arg Lys Asn Lys Ala Gly Val Val Ile His Cys Asn His 
225                 230                 235                 240 


Arg Ile Pro Phe Gly Asp Trp Phe Glu Tyr Val Ser Ser Pro Asn Tyr 
                245                 250                 255     


Leu Ala Glu Leu Met Ile Tyr Val Ser Met Ala Val Thr Phe Gly Phe 
            260                 265                 270         


His Asn Leu Thr Trp Trp Leu Val Val Thr Asn Val Phe Phe Asn Gln 
        275                 280                 285             


Ala Leu Ser Ala Phe Leu Ser His Gln Phe Tyr Lys Ser Lys Phe Val 
    290                 295                 300                 


Ser Tyr Pro Lys His Arg Lys Ala Phe Leu Pro Phe Leu Phe 
305                 310                 315             


<210>  5054
<211>  856
<212>  PRT
<213>  Homo sapiens

<400>  5054

Met Ala Ser Ala Asp Lys Asn Gly Gly Ser Val Ser Ser Val Ser Ser 
1               5                   10                  15      


Ser Arg Leu Gln Ser Arg Lys Pro Pro Asn Leu Ser Ile Thr Ile Pro 
            20                  25                  30          


Pro Pro Glu Lys Glu Thr Gln Ala Pro Gly Glu Gln Asp Ser Met Leu 
        35                  40                  45              


Pro Glu Gly Phe Gln Asn Arg Arg Leu Lys Lys Ser Gln Pro Arg Thr 
    50                  55                  60                  


Trp Ala Ala His Thr Thr Ala Cys Pro Pro Ser Phe Leu Pro Lys Arg 
65                  70                  75                  80  


Lys Asn Pro Ala Tyr Leu Lys Ser Val Ser Leu Gln Glu Pro Arg Ser 
                85                  90                  95      


Arg Trp Gln Glu Ser Ser Glu Lys Arg Pro Gly Phe Arg Arg Gln Ala 
            100                 105                 110         


Ser Leu Ser Gln Ser Ile Arg Lys Gly Ala Ala Gln Trp Phe Gly Val 
        115                 120                 125             


Ser Gly Asp Trp Glu Gly Gln Arg Gln Gln Trp Gln Arg Arg Ser Leu 
    130                 135                 140                 


His His Cys Ser Met Arg Tyr Gly Arg Leu Lys Ala Ser Cys Gln Arg 
145                 150                 155                 160 


Asp Leu Glu Leu Pro Ser Gln Glu Ala Pro Ser Phe Gln Gly Thr Glu 
                165                 170                 175     


Ser Pro Lys Pro Cys Lys Met Pro Lys Ile Val Asp Pro Leu Ala Arg 
            180                 185                 190         


Gly Arg Ala Phe Arg His Pro Glu Glu Met Asp Arg Pro His Ala Pro 
        195                 200                 205             


His Pro Pro Leu Thr Pro Gly Val Leu Ser Leu Thr Ser Phe Thr Ser 
    210                 215                 220                 


Val Arg Ser Gly Tyr Ser His Leu Pro Arg Arg Lys Arg Met Ser Val 
225                 230                 235                 240 


Ala His Met Ser Leu Gln Ala Ala Ala Ala Leu Leu Lys Gly Arg Ser 
                245                 250                 255     


Val Leu Asp Ala Thr Gly Gln Arg Cys Arg Val Val Lys Arg Ser Phe 
            260                 265                 270         


Ala Phe Pro Ser Phe Leu Glu Glu Asp Val Val Asp Gly Ala Asp Thr 
        275                 280                 285             


Phe Asp Ser Ser Phe Phe Ser Lys Glu Glu Met Ser Ser Met Pro Asp 
    290                 295                 300                 


Asp Val Phe Glu Ser Pro Pro Leu Ser Ala Ser Tyr Phe Arg Gly Ile 
305                 310                 315                 320 


Pro His Ser Ala Ser Pro Val Ser Pro Asp Gly Val Gln Ile Pro Leu 
                325                 330                 335     


Lys Glu Tyr Gly Arg Ala Pro Val Pro Gly Pro Arg Arg Gly Lys Arg 
            340                 345                 350         


Ile Ala Ser Lys Val Lys His Phe Ala Phe Asp Arg Lys Lys Arg His 
        355                 360                 365             


Tyr Gly Leu Gly Val Val Gly Asn Trp Leu Asn Arg Ser Tyr Arg Arg 
    370                 375                 380                 


Ser Ile Ser Ser Thr Val Gln Arg Gln Leu Glu Ser Phe Asp Ser His 
385                 390                 395                 400 


Arg Pro Tyr Phe Thr Tyr Trp Leu Thr Phe Val His Val Ile Ile Thr 
                405                 410                 415     


Leu Leu Val Ile Cys Thr Tyr Gly Ile Ala Pro Val Gly Phe Ala Gln 
            420                 425                 430         


His Val Thr Thr Gln Leu Val Leu Arg Asn Lys Gly Val Tyr Glu Ser 
        435                 440                 445             


Val Lys Tyr Ile Gln Gln Glu Asn Phe Trp Val Gly Pro Ser Ser Ile 
    450                 455                 460                 


Asp Leu Ile His Leu Gly Ala Lys Phe Ser Pro Cys Ile Arg Lys Asp 
465                 470                 475                 480 


Gly Gln Ile Glu Gln Leu Val Leu Arg Glu Arg Asp Leu Glu Arg Asp 
                485                 490                 495     


Ser Gly Cys Cys Val Gln Asn Asp His Ser Gly Cys Ile Gln Thr Gln 
            500                 505                 510         


Arg Lys Asp Cys Ser Glu Thr Leu Ala Thr Phe Val Lys Trp Gln Asp 
        515                 520                 525             


Asp Thr Gly Pro Pro Met Asp Lys Ser Asp Leu Gly Gln Lys Arg Thr 
    530                 535                 540                 


Ser Gly Ala Val Cys His Gln Asp Pro Arg Thr Cys Glu Glu Pro Ala 
545                 550                 555                 560 


Ser Ser Gly Ala His Ile Trp Pro Asp Asp Ile Thr Lys Trp Pro Ile 
                565                 570                 575     


Cys Thr Glu Gln Ala Arg Ser Asn His Thr Gly Phe Leu His Met Asp 
            580                 585                 590         


Cys Glu Ile Lys Gly Arg Pro Cys Cys Ile Gly Thr Lys Gly Ser Cys 
        595                 600                 605             


Glu Ile Thr Thr Arg Glu Tyr Cys Glu Phe Met His Gly Tyr Phe His 
    610                 615                 620                 


Glu Glu Ala Thr Leu Cys Ser Gln Val His Cys Leu Asp Lys Val Cys 
625                 630                 635                 640 


Gly Leu Leu Pro Phe Leu Asn Pro Glu Val Pro Asp Gln Phe Tyr Arg 
                645                 650                 655     


Leu Trp Leu Ser Leu Phe Leu His Ala Gly Val Val His Cys Leu Val 
            660                 665                 670         


Ser Val Val Phe Gln Met Thr Ile Leu Arg Asp Leu Glu Lys Leu Ala 
        675                 680                 685             


Gly Trp His Arg Ile Ala Ile Ile Phe Ile Leu Ser Gly Ile Thr Gly 
    690                 695                 700                 


Asn Leu Ala Ser Ala Ile Phe Leu Pro Tyr Arg Ala Glu Val Gly Pro 
705                 710                 715                 720 


Ala Gly Ser Gln Phe Gly Leu Leu Ala Cys Leu Phe Val Glu Leu Phe 
                725                 730                 735     


Gln Ser Trp Pro Leu Leu Glu Arg Pro Trp Lys Ala Phe Leu Asn Leu 
            740                 745                 750         


Ser Ala Ile Val Leu Phe Leu Phe Ile Cys Gly Leu Leu Pro Trp Ile 
        755                 760                 765             


Asp Asn Ile Ala His Ile Phe Gly Phe Leu Ser Gly Leu Leu Leu Ala 
    770                 775                 780                 


Phe Ala Phe Leu Pro Tyr Ile Thr Phe Gly Thr Ser Asp Lys Tyr Arg 
785                 790                 795                 800 


Lys Arg Ala Leu Ile Leu Val Ser Leu Leu Ala Phe Ala Gly Leu Phe 
                805                 810                 815     


Ala Ala Leu Val Leu Trp Leu Tyr Ile Tyr Pro Ile Asn Trp Pro Trp 
            820                 825                 830         


Ile Glu His Leu Thr Cys Phe Pro Phe Thr Ser Arg Phe Cys Glu Lys 
        835                 840                 845             


Tyr Glu Leu Asp Gln Val Leu His 
    850                 855     


<210>  5055
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  5055

Met Thr Val Gln Arg Leu Val Ala Ala Ala Val Leu Val Ala Leu Val 
1               5                   10                  15      


Ser Leu Ile Leu Asn Asn Val Ala Ala Phe Thr Ser Asn Trp Val Cys 
            20                  25                  30          


Gln Thr Leu Glu Asp Gly Arg Arg Arg Ser Val Gly Leu Trp Arg Ser 
        35                  40                  45              


Cys Trp Leu Val Asp Arg Thr Arg Gly Gly Pro Ser Pro Gly Ala Arg 
    50                  55                  60                  


Ala Gly Gln Val Asp Ala His Asp Cys Glu Ala Leu Gly Trp Gly Ser 
65                  70                  75                  80  


Glu Ala Ala Gly Phe Gln Glu Ser Arg Gly Thr Val Lys Leu Gln Phe 
                85                  90                  95      


Asp Met Met Arg Ala Cys Asn Leu Val Ala Thr Ala Ala Leu Thr Ala 
            100                 105                 110         


Gly Gln Leu Thr Phe Leu Leu Gly Leu Val Gly Leu Pro Leu Leu Ser 
        115                 120                 125             


Pro Asp Ala Pro Cys Trp Glu Glu Ala Met Ala Ala Ala Phe Gln Leu 
    130                 135                 140                 


Ala Ser Phe Val Leu Val Ile Gly Leu Val Thr Phe Tyr Arg Ile Gly 
145                 150                 155                 160 


Pro Tyr Thr Asn Leu Ser Trp Ser Cys Tyr Leu Asn Ile Gly Ala Cys 
                165                 170                 175     


Leu Leu Ala Thr Leu Ala Ala Ala Met Leu Ile Trp Asn Ile Leu His 
            180                 185                 190         


Lys Arg Glu Asp Cys Met Ala Pro Arg Val Ile Val Ile Ser Arg Ser 
        195                 200                 205             


Leu Thr Ala Arg Phe Arg Arg Gly Leu Asp Asn Asp Tyr Val Glu Ser 
    210                 215                 220                 


Pro Cys 
225     


<210>  5056
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  5056

Met Asp Leu Ala Gln Pro Ser Gln Pro Val Asp Glu Leu Glu Leu Ser 
1               5                   10                  15      


Val Leu Glu Arg Gln Pro Glu Glu Asn Thr Pro Leu Asn Gly Ala Asp 
            20                  25                  30          


Lys Val Phe Pro Ser Leu Asp Glu Glu Val Pro Pro Ala Glu Ala Asn 
        35                  40                  45              


Lys Glu Ser Pro Trp Ser Ser Cys Asn Lys Asn Val Val Gly Arg Cys 
    50                  55                  60                  


Lys Leu Trp Met Ile Ile Thr Ser Ile Phe Leu Gly Val Ile Thr Val 
65                  70                  75                  80  


Ile Ile Ile Gly Leu Cys Leu Ala Ala Val Thr Tyr Val Asp Glu Asp 
                85                  90                  95      


Glu Asn Glu Ile Leu Glu Leu Ser Ser Asn Lys Thr Phe Phe Ile Met 
            100                 105                 110         


Leu Lys Ile Pro Glu Glu Cys Val Ala Glu Glu Glu Leu Pro His Leu 
        115                 120                 125             


Leu Thr Glu Arg Leu Thr Asp Val Tyr Ser Thr Ser Pro Ser Leu Ser 
    130                 135                 140                 


Arg Tyr Phe Thr Ser Val Glu Ile Val Asp Phe Ser Gly Glu Asn Ala 
145                 150                 155                 160 


Thr Val Thr Tyr Asp Leu Gln Phe Gly Val Pro Ser Asp Asp Glu Asn 
                165                 170                 175     


Phe Met Lys Tyr Met Met Ser Glu Glu Leu Val Leu Gly Ile Leu Leu 
            180                 185                 190         


Gln Asp Phe Arg Asp Gln Asn Ile Pro Gly Cys Glu Ser Leu Gly Leu 
        195                 200                 205             


Asp Pro Thr Ser Leu Leu Leu Tyr Glu 
    210                 215         


<210>  5057
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  5057

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Lys Ala Ser Leu Cys Val Ser Ser Phe Phe Ala Ile Ser Trp Ala Leu 
            260                 265                 270         


Leu Pro Leu Ser Pro Tyr Leu Met Leu Lys 
        275                 280         


<210>  5058
<211>  714
<212>  PRT
<213>  Homo sapiens

<400>  5058

Met Thr Gln Met Ser Gln Val Gln Glu Leu Phe His Glu Ala Ala Gln 
1               5                   10                  15      


Gln Asp Ala Leu Ala Gln Pro Gln Pro Trp Trp Lys Thr Gln Leu Phe 
            20                  25                  30          


Met Trp Glu Pro Val Leu Phe Gly Thr Trp Asp Gly Val Phe Thr Ser 
        35                  40                  45              


Cys Met Ile Asn Ile Phe Gly Val Val Leu Phe Leu Arg Thr Gly Trp 
    50                  55                  60                  


Leu Val Gly Asn Thr Gly Val Leu Leu Gly Met Phe Leu Val Ser Phe 
65                  70                  75                  80  


Val Ile Leu Val Ala Leu Val Thr Val Leu Ser Gly Ile Gly Val Gly 
                85                  90                  95      


Glu Arg Ser Ser Ile Gly Ser Gly Gly Val Tyr Ser Met Ile Ser Ser 
            100                 105                 110         


Val Leu Gly Gly Gln Thr Gly Gly Thr Ile Gly Leu Leu Tyr Val Phe 
        115                 120                 125             


Gly Gln Cys Val Ala Gly Ala Met Tyr Ile Thr Gly Phe Ala Glu Ser 
    130                 135                 140                 


Ile Ser Asp Leu Leu Gly Leu Gly Asn Ile Trp Ala Val Arg Gly Ile 
145                 150                 155                 160 


Ser Val Ala Val Leu Leu Ala Leu Leu Gly Ile Asn Leu Ala Gly Val 
                165                 170                 175     


Lys Trp Ile Ile Arg Leu Gln Leu Leu Leu Leu Phe Leu Leu Ala Val 
            180                 185                 190         


Ser Thr Leu Asp Phe Val Val Gly Ser Phe Thr His Leu Asp Pro Glu 
        195                 200                 205             


His Gly Phe Ile Gly Tyr Ser Pro Glu Leu Leu Gln Asn Asn Thr Leu 
    210                 215                 220                 


Pro Asp Tyr Ser Pro Gly Glu Ser Phe Phe Thr Val Phe Gly Val Phe 
225                 230                 235                 240 


Phe Pro Ala Ala Thr Gly Val Met Ala Gly Phe Asn Met Gly Gly Asp 
                245                 250                 255     


Leu Arg Glu Pro Ala Ala Ser Ile Pro Leu Gly Ser Leu Ala Ala Val 
            260                 265                 270         


Gly Ile Ser Trp Phe Leu Tyr Ile Val Phe Val Phe Leu Leu Gly Ala 
        275                 280                 285             


Ile Cys Thr Arg Glu Ala Leu Arg Tyr Asp Phe Leu Ile Ala Glu Lys 
    290                 295                 300                 


Val Ser Leu Met Gly Phe Leu Phe Leu Leu Gly Leu Tyr Ile Ser Ser 
305                 310                 315                 320 


Leu Ala Ser Cys Met Gly Gly Leu Tyr Gly Ala Pro Arg Ile Leu Gln 
                325                 330                 335     


Cys Ile Ala Gln Glu Lys Val Ile Pro Ala Leu Ala Cys Leu Gly Gln 
            340                 345                 350         


Gly Lys Gly Pro Asn Lys Thr Pro Val Ala Ala Ile Cys Leu Thr Ser 
        355                 360                 365             


Leu Val Thr Met Ala Phe Val Phe Val Gly Gln Val Asn Val Leu Ala 
    370                 375                 380                 


Pro Ile Val Thr Ile Asn Phe Met Leu Thr Tyr Val Ala Val Asp Tyr 
385                 390                 395                 400 


Ser Tyr Phe Ser Leu Ser Met Cys Ser Cys Ser Leu Thr Pro Val Pro 
                405                 410                 415     


Glu Pro Val Leu Arg Glu Gly Ala Glu Gly Leu His Cys Ser Glu His 
            420                 425                 430         


Leu Leu Leu Glu Lys Ala Pro Ser Tyr Gly Ser Glu Gly Pro Ala Gln 
        435                 440                 445             


Arg Val Leu Glu Gly Thr Leu Leu Glu Phe Thr Lys Asp Met Asp Gln 
    450                 455                 460                 


Leu Leu Gln Leu Thr Arg Lys Leu Glu Ser Ser Gln Pro Arg Gln Gly 
465                 470                 475                 480 


Glu Gly Asn Arg Thr Pro Glu Ser Gln Lys Arg Lys Ser Lys Lys Ala 
                485                 490                 495     


Thr Lys Gln Thr Leu Gln Asp Ser Phe Leu Leu Asp Leu Lys Ser Pro 
            500                 505                 510         


Pro Ser Phe Pro Val Glu Ile Ser Asp Arg Leu Pro Ala Ala Ser Trp 
        515                 520                 525             


Glu Gly Gln Glu Ser Cys Trp Asn Lys Gln Thr Ser Lys Ser Glu Gly 
    530                 535                 540                 


Thr Gln Pro Glu Gly Thr Tyr Gly Glu Gln Leu Val Pro Glu Leu Cys 
545                 550                 555                 560 


Asn Gln Ser Glu Ser Ser Gly Glu Asp Phe Phe Leu Lys Ser Arg Leu 
                565                 570                 575     


Gln Glu Gln Asp Val Trp Arg Arg Ser Thr Ser Phe Tyr Thr His Met 
            580                 585                 590         


Cys Asn Pro Trp Val Ser Leu Leu Gly Ala Val Gly Ser Leu Leu Ile 
        595                 600                 605             


Met Phe Val Ile Gln Trp Val Tyr Thr Leu Val Asn Met Gly Val Ala 
    610                 615                 620                 


Ala Ile Val Tyr Phe Tyr Ile Gly Arg Ala Ser Pro Gly Leu His Leu 
625                 630                 635                 640 


Gly Ser Ala Ser Asn Phe Ser Phe Phe Arg Trp Met Arg Ser Leu Leu 
                645                 650                 655     


Leu Pro Ser Cys Arg Ser Leu Arg Ser Pro Gln Glu Gln Ile Ile Leu 
            660                 665                 670         


Ala Pro Ser Leu Ala Lys Val Asp Met Glu Met Thr Gln Leu Thr Gln 
        675                 680                 685             


Glu Asn Ala Asp Phe Ala Thr Arg Asp Arg Tyr His His Ser Ser Leu 
    690                 695                 700                 


Val Asn Arg Glu Gln Leu Met Pro His Tyr 
705                 710                 


<210>  5059
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  5059

Met Pro Pro Gly Gly Gly Gly Pro Met Lys Asp Cys Glu Tyr Ser Gln 
1               5                   10                  15      


Ile Ser Thr His Ser Ser Ser Pro Met Glu Ser Pro His Lys Lys Lys 
            20                  25                  30          


Lys Ile Ala Ala Arg Arg Lys Trp Glu Val Phe Pro Gly Arg Asn Lys 
        35                  40                  45              


Phe Phe Cys Asn Gly Arg Ile Met Met Ala Arg Gln Thr Gly Val Phe 
    50                  55                  60                  


Tyr Leu Thr Leu Val Leu Ile Leu Val Thr Ser Gly Leu Phe Phe Ala 
65                  70                  75                  80  


Phe Asp Cys Pro Tyr Leu Ala Val Lys Ile Thr Pro Ala Ile Pro Ala 
                85                  90                  95      


Val Ala Gly Ile Leu Phe Phe Phe Val Met Gly Thr Leu Leu Arg Thr 
            100                 105                 110         


Ser Phe Ser Asp Pro Gly Val Leu Pro Arg Ala Thr Pro Asp Glu Ala 
        115                 120                 125             


Ala Asp Leu Glu Arg Gln Ile Asp Ile Ala Asn Gly Thr Ser Ser Gly 
    130                 135                 140                 


Gly Tyr Arg Pro Pro Pro Arg Thr Lys Glu Val Ile Ile Asn Gly Gln 
145                 150                 155                 160 


Thr Val Lys Leu Lys Tyr Cys Phe Thr Cys Lys Ile Phe Arg Pro Pro 
                165                 170                 175     


Arg Ala Ser His Cys Ser Leu Cys Asp Asn Cys Val Glu Arg Phe Asp 
            180                 185                 190         


His His Cys Pro Trp Val Gly Asn Cys Val Gly Lys Arg Asn Tyr Arg 
        195                 200                 205             


Phe Phe Tyr Met Phe Ile Leu Ser Leu Ser Phe Leu Thr Val Phe Ile 
    210                 215                 220                 


Phe Ala Phe Val Ile Thr His Val Ile Leu Arg Ser Gln Gln Thr Gly 
225                 230                 235                 240 


Phe Leu Asn Ala Leu Lys Asp Ser Pro Ala Ser Val Leu Glu Ala Val 
                245                 250                 255     


Val Cys Phe Phe Ser Val Trp Ser Ile Val Gly Leu Ser Gly Phe His 
            260                 265                 270         


Thr Tyr Leu Ile Ser Ser Asn Gln Thr Thr Asn Glu Asp Ile Lys Gly 
        275                 280                 285             


Ser Trp Ser Asn Lys Arg Gly Lys Glu Asn Tyr Asn Pro Tyr Ser Tyr 
    290                 295                 300                 


Gly Asn Ile Phe Thr Asn Cys Cys Val Ala Leu Cys Gly Pro Ile Ser 
305                 310                 315                 320 


Pro Ser Leu Ile Asp Arg Arg Gly Tyr Ile Gln Pro Asp Thr Pro Gln 
                325                 330                 335     


Pro Ala Ala Pro Ser Asn Gly Ile Thr Met Tyr Gly Ala Thr Gln Ser 
            340                 345                 350         


Gln Ser Asp Met Cys Asp Gln Asp Gln Cys Ile Gln Ser Thr Lys Phe 
        355                 360                 365             


Val Leu Gln Ala Ala Ala Thr Pro Leu Leu Gln Ser Glu Pro Ser Leu 
    370                 375                 380                 


Thr Ser Asp Glu Leu His Leu Pro Gly Lys Pro Gly Leu Gly Thr Pro 
385                 390                 395                 400 


Cys Ala Ser Leu Thr Leu Gly Pro Pro Thr Pro Pro Ala Ser Met Pro 
                405                 410                 415     


Asn Leu Ala Glu Ala Thr Leu Ala Asp Val Met Pro Arg Lys Asp Glu 
            420                 425                 430         


His Met Gly His Gln Phe Leu Thr Pro Asp Glu Ala Pro Ser Pro Pro 
        435                 440                 445             


Arg Leu Leu Ala Ala Gly Ser Pro Leu Ala His Ser Arg Thr Met His 
    450                 455                 460                 


Val Leu Gly Leu Ala Ser Gln Asp Ser Leu His Glu Asp Ser Val Arg 
465                 470                 475                 480 


Gly Leu Val Lys Leu Ser Ser Val 
                485             


<210>  5060
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  5060

Met Glu Lys Thr Cys Ile Asp Ala Leu Pro Leu Thr Met Asn Ser Ser 
1               5                   10                  15      


Glu Lys Gln Glu Thr Val Cys Ile Phe Gly Thr Gly Asp Phe Gly Arg 
            20                  25                  30          


Ser Leu Gly Leu Lys Met Leu Gln Cys Gly Tyr Ser Val Val Phe Gly 
        35                  40                  45              


Ser Arg Asn Pro Gln Lys Thr Thr Leu Leu Pro Ser Gly Ala Glu Val 
    50                  55                  60                  


Leu Ser Tyr Ser Glu Ala Ala Lys Lys Ser Gly Ile Ile Ile Ile Ala 
65                  70                  75                  80  


Ile His Arg Glu His Tyr Asp Phe Leu Thr Glu Leu Thr Glu Val Leu 
                85                  90                  95      


Asn Gly Lys Ile Leu Val Asp Ile Ser Asn Asn Leu Lys Ile Asn Gln 
            100                 105                 110         


Tyr Pro Glu Ser Asn Ala Glu Tyr Leu Ala His Leu Val Pro Gly Ala 
        115                 120                 125             


His Val Val Lys Ala Phe Asn Thr Ile Ser Ala Trp Ala Leu Gln Ser 
    130                 135                 140                 


Gly Ala Leu Asp Ala Ser Arg Gln Val Phe Val Cys Gly Asn Asp Ser 
145                 150                 155                 160 


Lys Ala Lys Gln Arg Val Met Asp Ile Val Arg Asn Leu Gly Leu Thr 
                165                 170                 175     


Pro Met Asp Gln Gly Ser Leu Met Ala Ala Lys Glu Ile Glu Lys Tyr 
            180                 185                 190         


Pro Leu Gln Leu Phe Pro Met Trp Arg Phe Pro Phe Tyr Leu Ser Ala 
        195                 200                 205             


Val Leu Cys Val Phe Leu Phe Phe Tyr Cys Val Ile Arg Asp Val Ile 
    210                 215                 220                 


Tyr Pro Tyr Val Tyr Glu Lys Lys Asp Asn Thr Phe Arg Met Ala Ile 
225                 230                 235                 240 


Ser Ile Pro Asn Arg Ile Phe Pro Ile Thr Ala Leu Thr Leu Leu Ala 
                245                 250                 255     


Leu Val Tyr Leu Pro Gly Val Ile Ala Ala Ile Leu Gln Leu Tyr Arg 
            260                 265                 270         


Gly Thr Lys Tyr Arg Arg Phe Pro Asp Trp Leu Asp His Trp Met Leu 
        275                 280                 285             


Cys Arg Lys Gln Leu Gly Leu Val Ala Leu Gly Phe Ala Phe Leu His 
    290                 295                 300                 


Val Leu Tyr Thr Leu Val Ile Pro Ile Arg Tyr Tyr Val Arg Trp Arg 
305                 310                 315                 320 


Leu Gly Asn Leu Thr Val Thr Gln Ala Ile Leu Lys Lys Glu Asn Pro 
                325                 330                 335     


Phe Ser Thr Ser Ser Ala Trp Leu Ser Asp Ser Tyr Val Ala Leu Gly 
            340                 345                 350         


Ile Leu Gly Phe Phe Leu Phe Val Leu Leu Gly Ile Thr Ser Leu Pro 
        355                 360                 365             


Ser Val Ser Asn Ala Val Asn Trp Arg Glu Phe Arg Phe Val Gln Ser 
    370                 375                 380                 


Lys Leu Gly Tyr Leu Thr Leu Ile Leu Cys Thr Ala His Thr Leu Val 
385                 390                 395                 400 


Tyr Gly Gly Lys Arg Phe Leu Ser Pro Ser Asn Leu Arg Trp Tyr Leu 
                405                 410                 415     


Pro Ala Ala Tyr Val Leu Gly Leu Ile Ile Pro Cys Thr Val Leu Val 
            420                 425                 430         


Ile Lys Phe Val Leu Ile Met Pro Cys Val Asp Asn Thr Leu Thr Arg 
        435                 440                 445             


Ile Arg Gln Gly Trp Glu Arg Asn Ser Lys His 
    450                 455                 


<210>  5061
<211>  486
<212>  PRT
<213>  Homo sapiens

<400>  5061

Met Gly Pro Leu Ser Pro Ala Arg Thr Leu Arg Leu Trp Gly Pro Arg 
1               5                   10                  15      


Ser Leu Gly Val Ala Leu Gly Val Phe Met Thr Ile Gly Phe Ala Leu 
            20                  25                  30          


Gln Leu Leu Gly Gly Pro Phe Gln Arg Arg Leu Pro Gly Leu Gln Leu 
        35                  40                  45              


Arg Gln Pro Ser Ala Pro Ser Leu Arg Pro Ala Leu Pro Ser Cys Pro 
    50                  55                  60                  


Pro Arg Gln Arg Leu Val Phe Leu Lys Thr His Lys Ser Gly Ser Ser 
65                  70                  75                  80  


Ser Val Leu Ser Leu Leu His Arg Tyr Gly Asp Gln His Gly Leu Arg 
                85                  90                  95      


Phe Ala Leu Pro Ala Arg Tyr Gln Phe Gly Tyr Pro Lys Leu Phe Gln 
            100                 105                 110         


Ala Ser Arg Val Lys Gly Tyr Arg Pro Gln Gly Gly Gly Thr Gln Leu 
        115                 120                 125             


Pro Phe His Ile Leu Cys His His Met Arg Phe Asn Leu Lys Glu Val 
    130                 135                 140                 


Leu Gln Val Met Pro Ser Asp Ser Phe Phe Phe Ser Ile Val Arg Asp 
145                 150                 155                 160 


Pro Ala Ala Leu Ala Arg Ser Ala Phe Ser Tyr Tyr Lys Ser Thr Ser 
                165                 170                 175     


Ser Ala Phe Arg Lys Ser Pro Ser Leu Ala Ala Phe Leu Ala Asn Pro 
            180                 185                 190         


Arg Gly Phe Tyr Arg Pro Gly Ala Arg Gly Asp His Tyr Ala Arg Asn 
        195                 200                 205             


Leu Leu Trp Phe Asp Phe Gly Leu Pro Phe Pro Pro Glu Lys Arg Ala 
    210                 215                 220                 


Lys Arg Gly Asn Ile His Pro Pro Arg Asp Pro Asn Pro Pro Gln Leu 
225                 230                 235                 240 


Gln Val Leu Pro Ser Gly Ala Gly Pro Arg Ala Gln Thr Leu Asn Pro 
                245                 250                 255     


Asn Ala Leu Ile His Pro Val Ser Thr Val Thr Asp His Arg Ser Gln 
            260                 265                 270         


Ile Ser Ser Pro Ala Ser Phe Asp Leu Gly Ser Ser Ser Phe Ile Gln 
        275                 280                 285             


Trp Gly Leu Ala Trp Leu Asp Ser Val Phe Asp Leu Val Met Val Ala 
    290                 295                 300                 


Glu Tyr Phe Asp Glu Ser Leu Val Leu Leu Ala Asp Ala Leu Cys Trp 
305                 310                 315                 320 


Gly Leu Asp Asp Val Val Gly Phe Met His Asn Ala Gln Ala Gly His 
                325                 330                 335     


Lys Gln Gly Leu Ser Thr Val Ser Asn Ser Gly Leu Thr Ala Glu Asp 
            340                 345                 350         


Arg Gln Leu Thr Ala Arg Ala Arg Ala Trp Asn Asn Leu Asp Trp Ala 
        355                 360                 365             


Leu Tyr Val His Phe Asn Arg Ser Leu Trp Ala Arg Ile Glu Lys Tyr 
    370                 375                 380                 


Gly Gln Gly Arg Leu Gln Thr Ala Val Ala Glu Leu Arg Ala Arg Arg 
385                 390                 395                 400 


Glu Ala Leu Ala Lys His Cys Leu Val Gly Gly Glu Ala Ser Asp Pro 
                405                 410                 415     


Lys Tyr Ile Thr Asp Arg Arg Phe Arg Pro Phe Gln Phe Gly Ser Ala 
            420                 425                 430         


Lys Val Leu Gly Tyr Ile Leu Arg Ser Gly Leu Ser Pro Gln Asp Gln 
        435                 440                 445             


Glu Glu Cys Glu Arg Leu Ala Thr Pro Glu Leu Gln Tyr Lys Asp Lys 
    450                 455                 460                 


Leu Asp Ala Lys Gln Phe Pro Pro Thr Val Ser Leu Pro Leu Lys Thr 
465                 470                 475                 480 


Ser Arg Pro Leu Ser Pro 
                485     


<210>  5062
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  5062

Met Ala Lys Phe Arg Arg Arg Thr Cys Ile Ile Leu Ala Leu Phe Ile 
1               5                   10                  15      


Leu Phe Ile Phe Ser Leu Met Met Gly Leu Lys Met Leu Arg Pro Asn 
            20                  25                  30          


Thr Ala Thr Phe Gly Ala Pro Phe Gly Leu Asp Leu Leu Pro Glu Leu 
        35                  40                  45              


His Gln Arg Thr Ile His Leu Gly Lys Asn Phe Asp Phe Gln Lys Ser 
    50                  55                  60                  


Asp Arg Ile Asn Ser Glu Thr Asn Thr Lys Asn Leu Lys Ser Val Glu 
65                  70                  75                  80  


Ile Thr Met Lys Pro Ser Lys Ala Ser Glu Leu Asn Leu Asp Glu Leu 
                85                  90                  95      


Pro Pro Leu Asn Asn Tyr Leu His Val Phe Tyr Tyr Ser Trp Tyr Gly 
            100                 105                 110         


Asn Pro Gln Phe Asp Gly Lys Tyr Ile His Trp Asn His Pro Val Leu 
        115                 120                 125             


Glu His Trp Asp Pro Arg Ile Ala Lys Asn Tyr Pro Gln Gly Arg His 
    130                 135                 140                 


Asn Pro Pro Asp Asp Ile Gly Ser Ser Phe Tyr Pro Glu Leu Gly Ser 
145                 150                 155                 160 


Tyr Ser Ser Arg Asp Pro Ser Val Ile Glu Thr His Met Arg Gln Met 
                165                 170                 175     


Arg Ser Ala Ser Ile Gly Val Leu Ala Leu Ser Trp Tyr Pro Pro Asp 
            180                 185                 190         


Val Asn Asp Glu Asn Gly Glu Pro Thr Asp Asn Leu Val Pro Thr Ile 
        195                 200                 205             


Leu Asp Lys Ala His Lys Tyr Asn Leu Lys Val Thr Phe His Ile Glu 
    210                 215                 220                 


Pro Tyr Ser Asn Arg Asp Asp Gln Asn Met Tyr Lys Asn Val Lys Tyr 
225                 230                 235                 240 


Ile Ile Asp Lys Tyr Gly Asn His Pro Ala Phe Tyr Arg Tyr Lys Thr 
                245                 250                 255     


Lys Thr Gly Asn Ala Leu Pro Met Phe Tyr Val Tyr Asp Ser Tyr Ile 
            260                 265                 270         


Thr Lys Pro Glu Lys Trp Ala Asn Leu Leu Thr Thr Ser Gly Ser Arg 
        275                 280                 285             


Ser Ile Arg Asn Ser Pro Tyr Asp Gly Leu Phe Ile Ala Leu Leu Val 
    290                 295                 300                 


Glu Glu Lys His Lys Tyr Asp Ile Leu Gln Ser Gly Phe Asp Gly Ile 
305                 310                 315                 320 


Tyr Thr Tyr Phe Ala Thr Asn Gly Phe Thr Tyr Gly Ser Ser His Gln 
                325                 330                 335     


Asn Trp Ala Ser Leu Lys Leu Phe Cys Asp Lys Tyr Asn Leu Ile Phe 
            340                 345                 350         


Ile Pro Ser Val Gly Pro Gly Tyr Ile Asp Thr Ser Ile Arg Pro Trp 
        355                 360                 365             


Asn Thr Gln Asn Thr Arg Asn Arg Ile Asn Gly Lys Tyr Tyr Glu Ile 
    370                 375                 380                 


Gly Leu Ser Ala Ala Leu Gln Thr Arg Pro Ser Leu Ile Ser Ile Thr 
385                 390                 395                 400 


Ser Phe Asn Glu Trp His Glu Gly Thr Gln Ile Glu Lys Ala Val Pro 
                405                 410                 415     


Lys Arg Thr Ser Asn Thr Val Tyr Leu Asp Tyr Arg Pro His Lys Pro 
            420                 425                 430         


Gly Leu Tyr Leu Glu Leu Thr Arg Lys Trp Ser Glu Lys Tyr Ser Lys 
        435                 440                 445             


Glu Arg Ala Thr Tyr Ala Leu Asp Arg Gln Leu Pro Val Ser 
    450                 455                 460         


<210>  5063
<211>  581
<212>  PRT
<213>  Homo sapiens

<400>  5063

Met Trp Gly Arg Thr Ala Arg Arg Arg Cys Pro Arg Glu Leu Arg Arg 
1               5                   10                  15      


Gly Arg Glu Ala Leu Leu Val Leu Leu Ala Leu Leu Ala Leu Ala Gly 
            20                  25                  30          


Leu Gly Ser Val Leu Arg Ala Gln Arg Gly Ala Gly Ala Gly Ala Ala 
        35                  40                  45              


Glu Pro Gly Pro Pro Arg Thr Pro Arg Pro Gly Arg Arg Glu Pro Val 
    50                  55                  60                  


Met Pro Arg Pro Pro Val Pro Ala Asn Ala Leu Gly Ala Arg Gly Glu 
65                  70                  75                  80  


Ala Val Arg Leu Gln Leu Gln Gly Glu Glu Leu Arg Leu Gln Glu Glu 
                85                  90                  95      


Ser Val Arg Leu His Gln Ile Asn Ile Tyr Leu Ser Asp Arg Ile Ser 
            100                 105                 110         


Leu His Arg Arg Leu Pro Glu Arg Trp Asn Pro Leu Cys Lys Glu Lys 
        115                 120                 125             


Lys Tyr Asp Tyr Asp Asn Leu Pro Arg Thr Ser Val Ile Ile Ala Phe 
    130                 135                 140                 


Tyr Asn Glu Ala Trp Ser Thr Leu Leu Arg Thr Val Tyr Ser Val Leu 
145                 150                 155                 160 


Glu Thr Ser Pro Asp Ile Leu Leu Glu Glu Val Ile Leu Val Asp Asp 
                165                 170                 175     


Tyr Ser Asp Arg Glu His Leu Lys Glu Arg Leu Ala Asn Glu Leu Ser 
            180                 185                 190         


Gly Leu Pro Lys Val Arg Leu Ile Arg Ala Asn Lys Arg Glu Gly Leu 
        195                 200                 205             


Val Arg Ala Arg Leu Leu Gly Ala Ser Ala Ala Arg Gly Asp Val Leu 
    210                 215                 220                 


Thr Phe Leu Asp Cys His Cys Glu Cys His Glu Gly Trp Leu Glu Pro 
225                 230                 235                 240 


Leu Leu Gln Arg Ile His Glu Glu Glu Ser Ala Val Val Cys Pro Val 
                245                 250                 255     


Ile Asp Val Ile Asp Trp Asn Thr Phe Glu Tyr Leu Gly Asn Ser Gly 
            260                 265                 270         


Glu Pro Gln Ile Gly Gly Phe Asp Trp Arg Leu Val Phe Thr Trp His 
        275                 280                 285             


Thr Val Pro Glu Arg Glu Arg Ile Arg Met Gln Ser Pro Val Asp Val 
    290                 295                 300                 


Ile Arg Ser Pro Thr Met Ala Gly Gly Leu Phe Ala Val Ser Lys Lys 
305                 310                 315                 320 


Tyr Phe Glu Tyr Leu Gly Ser Tyr Asp Thr Gly Met Glu Val Trp Gly 
                325                 330                 335     


Gly Glu Asn Leu Glu Phe Ser Phe Arg Ile Trp Gln Cys Gly Gly Val 
            340                 345                 350         


Leu Glu Thr His Pro Cys Ser His Val Gly His Val Phe Pro Lys Gln 
        355                 360                 365             


Ala Pro Tyr Ser Arg Asn Lys Ala Leu Ala Asn Ser Val Arg Ala Ala 
    370                 375                 380                 


Glu Val Trp Met Asp Glu Phe Lys Glu Leu Tyr Tyr His Arg Asn Pro 
385                 390                 395                 400 


Arg Ala Arg Leu Glu Pro Phe Gly Asp Val Thr Glu Arg Lys Gln Leu 
                405                 410                 415     


Arg Asp Lys Leu Gln Cys Lys Asp Phe Lys Trp Phe Leu Glu Thr Val 
            420                 425                 430         


Tyr Pro Glu Leu His Val Pro Glu Asp Arg Pro Gly Phe Phe Gly Met 
        435                 440                 445             


Leu Gln Asn Lys Gly Leu Thr Asp Tyr Cys Phe Asp Tyr Asn Pro Pro 
    450                 455                 460                 


Asp Glu Asn Gln Ile Val Gly His Gln Val Ile Leu Tyr Leu Cys His 
465                 470                 475                 480 


Gly Met Gly Gln Asn Gln Phe Phe Glu Tyr Thr Ser Gln Lys Glu Ile 
                485                 490                 495     


Arg Tyr Asn Thr His Gln Pro Glu Gly Cys Ile Ala Val Glu Ala Gly 
            500                 505                 510         


Met Asp Thr Leu Ile Met His Leu Cys Glu Glu Thr Ala Pro Glu Asn 
        515                 520                 525             


Gln Lys Phe Ile Leu Gln Glu Asp Gly Ser Leu Phe His Glu Gln Ser 
    530                 535                 540                 


Lys Lys Cys Val Gln Ala Ala Arg Lys Glu Ser Ser Asp Ser Phe Val 
545                 550                 555                 560 


Pro Leu Leu Arg Asp Cys Thr Asn Ser Asp His Gln Lys Trp Phe Phe 
                565                 570                 575     


Lys Glu Arg Met Leu 
            580     


<210>  5064
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  5064

Met Ala Pro Gln Arg Arg Ala Ala Thr Lys Ala Pro Glu Gly Asn Gly 
1               5                   10                  15      


Ala Ala Glu Arg Arg Asn Arg Ser Ser Thr Lys Lys Asp Arg Ala Pro 
            20                  25                  30          


Arg Glu Val Gln Arg Leu Trp Gln Arg Pro Trp Leu Arg Thr Ala Gly 
        35                  40                  45              


Leu Gly Ala Gly Phe Val Leu Thr Ala Leu Leu Leu Trp Ser Ser Leu 
    50                  55                  60                  


Gly Ala Asp Asp Gly Val Ala Glu Val Leu Ala Arg Arg Gly Glu Val 
65                  70                  75                  80  


Val Ala Gly Arg Phe Ile Glu Val Pro Cys Ser Glu Asp Tyr Asp Ser 
                85                  90                  95      


His Arg Arg Phe Glu Gly Cys Thr Pro Arg Lys Cys Gly Arg Gly Val 
            100                 105                 110         


Thr Asp Val Val Ile Thr Arg Glu Glu Ala Glu Arg Ile Arg Ser Val 
        115                 120                 125             


Ala Glu Lys Gly Leu Ser Leu Gly Gly Ser Asp Gly Gly Ala Ser Ile 
    130                 135                 140                 


Leu Asp Leu His Ser Gly Ala Leu Ser Val Gly Lys His Phe Val Asn 
145                 150                 155                 160 


Leu Tyr Arg Tyr Phe Gly Asp Lys Ile Gln Asn Ile Phe Ser Glu Glu 
                165                 170                 175     


Asp Phe Arg Leu Tyr Arg Glu Val Arg Gln Lys Val Gln Leu Thr Ile 
            180                 185                 190         


Ala Glu Ala Phe Gly Ile Ser Ala Ser Ser Leu His Leu Thr Lys Pro 
        195                 200                 205             


Thr Phe Phe Ser Arg Ile Asn Ser Thr Glu Ala Arg Thr Ala His Asp 
    210                 215                 220                 


Glu Tyr Trp His Ala His Val Asp Lys Val Thr Tyr Gly Ser Phe Asp 
225                 230                 235                 240 


Tyr Thr Ser Leu Leu Tyr Leu Ser Asn Tyr Leu Glu Asp Phe Gly Gly 
                245                 250                 255     


Gly Arg Phe Met Phe Met Glu Glu Gly Ala Asn Lys Thr Val Glu Pro 
            260                 265                 270         


Arg Ala Gly Arg Val Ser Phe Phe Thr Ser Gly Ser Glu Asn Leu His 
        275                 280                 285             


Arg Val Glu Lys Val His Trp Gly Thr Arg Tyr Ala Ile Thr Ile Ala 
    290                 295                 300                 


Phe Ser Cys Asn Pro Asp His Gly Ile Glu Asp Pro Ala Phe Pro 
305                 310                 315                 


<210>  5065
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  5065

Met Met Gly Arg Ser Pro Gly Phe Ala Met Gln His Ile Val Gly Val 
1               5                   10                  15      


Pro His Val Leu Val Arg Arg Gly Leu Leu Gly Arg Asp Leu Phe Met 
            20                  25                  30          


Thr Arg Thr Leu Cys Ser Pro Gly Pro Ser Gln Pro Gly Glu Lys Arg 
        35                  40                  45              


Pro Glu Glu Val Ala Leu Gly Leu His His Arg Leu Pro Ala Leu Gly 
    50                  55                  60                  


Arg Ala Leu Gly His Ser Ile Gln Gln Arg Ala Thr Ser Thr Ala Lys 
65                  70                  75                  80  


Thr Trp Trp Asp Arg Tyr Glu Glu Phe Val Gly Leu Asn Glu Val Arg 
                85                  90                  95      


Glu Ala Gln Gly Lys Val Thr Glu Ala Glu Lys Val Phe Met Val Ala 
            100                 105                 110         


Arg Gly Leu Val Arg Glu Ala Arg Glu Asp Leu Glu Val His Gln Ala 
        115                 120                 125             


Lys Leu Lys Glu Val Arg Asp Arg Leu Asp Arg Val Ser Arg Glu Asp 
    130                 135                 140                 


Ser Gln Tyr Leu Glu Leu Ala Thr Leu Glu His Arg Met Leu Gln Glu 
145                 150                 155                 160 


Glu Lys Arg Leu Arg Thr Ala Tyr Leu Arg Ala Glu Asp Ser Glu Arg 
                165                 170                 175     


Glu Lys Phe Ser Leu Phe Ser Ala Ala Val Arg Glu Ser His Glu Lys 
            180                 185                 190         


Glu Arg Thr Arg Ala Glu Arg Thr Lys Asn Trp Ser Leu Ile Gly Ser 
        195                 200                 205             


Val Leu Gly Ala Leu Ile Gly Val Ala Gly Ser Thr Tyr Val Asn Arg 
    210                 215                 220                 


Val Arg Leu Gln Glu Leu Lys Ala Leu Leu Leu Glu Ala Gln Lys Gly 
225                 230                 235                 240 


Pro Val Ser Leu Gln Glu Ala Ile Arg Glu Gln Ala Ser Ser Tyr Ser 
                245                 250                 255     


Arg Gln Gln Arg Asp Leu His Asn Leu Met Val Asp Leu Arg Gly Leu 
            260                 265                 270         


Val His Ala Ala Gly Pro Gly Gln Asp Ser Gly Ser Gln Ala Gly Ser 
        275                 280                 285             


Pro Pro Thr Arg Asp Arg Asp Val Asp Val Leu Ser Ala Ala Leu Lys 
    290                 295                 300                 


Glu Gln Leu Ser His Ser Arg Gln Val His Ser Cys Leu Glu Gly Leu 
305                 310                 315                 320 


Arg Glu Gln Leu Asp Gly Leu Glu Lys Thr Cys Ser Gln Met Ala Gly 
                325                 330                 335     


Val Val Gln Leu Val Lys Ser Ala Ala His Pro Gly Leu Val Glu Pro 
            340                 345                 350         


Ala Asp Gly Ala Met Pro Ser Phe Leu Leu Glu Gln Gly Ser Met Ile 
        355                 360                 365             


Leu Ala Leu Ser Asp Thr Glu Gln Arg Leu Glu Ala Gln Val Asn Arg 
    370                 375                 380                 


Asn Thr Ile Tyr Ser Thr Leu Val Thr Cys Val Thr Phe Val Ala Thr 
385                 390                 395                 400 


Leu Pro Val Leu Tyr Met Leu Phe Lys Ala Ser 
                405                 410     


<210>  5066
<211>  1025
<212>  PRT
<213>  Homo sapiens

<400>  5066

Met His Arg Lys Lys Val Asp Asn Arg Ile Arg Ile Leu Ile Glu Asn 
1               5                   10                  15      


Gly Val Ala Glu Arg Gln Arg Ser Leu Phe Val Val Val Gly Asp Arg 
            20                  25                  30          


Gly Lys Asp Gln Val Val Ile Leu His His Met Leu Ser Lys Ala Thr 
        35                  40                  45              


Val Lys Ala Arg Pro Ser Val Leu Trp Cys Tyr Lys Lys Glu Leu Gly 
    50                  55                  60                  


Phe Ser Ser His Arg Lys Lys Arg Met Arg Gln Leu Gln Lys Lys Ile 
65                  70                  75                  80  


Lys Asn Gly Thr Leu Asn Ile Lys Gln Asp Asp Pro Phe Glu Leu Phe 
                85                  90                  95      


Ile Ala Ala Thr Asn Ile Arg Tyr Cys Tyr Tyr Asn Glu Thr His Lys 
            100                 105                 110         


Ile Leu Gly Asn Thr Phe Gly Met Cys Val Leu Gln Asp Phe Glu Ala 
        115                 120                 125             


Leu Thr Pro Asn Leu Leu Ala Arg Thr Val Glu Thr Val Glu Gly Gly 
    130                 135                 140                 


Gly Leu Val Val Ile Leu Leu Arg Thr Met Asn Ser Leu Lys Gln Leu 
145                 150                 155                 160 


Tyr Thr Val Thr Met Asp Val His Ser Arg Tyr Arg Thr Glu Ala His 
                165                 170                 175     


Gln Asp Val Val Gly Arg Phe Asn Glu Arg Phe Ile Leu Ser Leu Ala 
            180                 185                 190         


Ser Cys Lys Lys Cys Leu Val Ile Asp Asp Gln Leu Asn Ile Leu Pro 
        195                 200                 205             


Ile Ser Ser His Val Ala Thr Met Glu Ala Leu Pro Pro Gln Thr Pro 
    210                 215                 220                 


Asp Glu Ser Leu Gly Pro Ser Asp Leu Glu Leu Arg Glu Leu Lys Glu 
225                 230                 235                 240 


Ser Leu Gln Asp Thr Gln Pro Val Gly Val Leu Val Asp Cys Cys Lys 
                245                 250                 255     


Thr Leu Asp Gln Ala Lys Ala Val Leu Lys Phe Ile Glu Gly Ile Ser 
            260                 265                 270         


Glu Lys Thr Leu Arg Ser Thr Val Ala Leu Thr Ala Ala Arg Gly Arg 
        275                 280                 285             


Gly Lys Ser Ala Ala Leu Gly Leu Ala Ile Ala Gly Ala Val Ala Phe 
    290                 295                 300                 


Gly Tyr Ser Asn Ile Phe Val Thr Ser Pro Ser Pro Asp Asn Leu His 
305                 310                 315                 320 


Thr Leu Phe Glu Phe Val Phe Lys Gly Phe Asp Ala Leu Gln Tyr Gln 
                325                 330                 335     


Glu His Leu Asp Tyr Glu Ile Ile Gln Ser Leu Asn Pro Glu Phe Asn 
            340                 345                 350         


Lys Ala Val Ile Arg Val Asn Val Phe Arg Glu His Arg Gln Thr Ile 
        355                 360                 365             


Gln Tyr Ile His Pro Ala Asp Ala Val Lys Leu Gly Gln Ala Glu Leu 
    370                 375                 380                 


Val Val Ile Asp Glu Ala Ala Ala Ile Pro Leu Pro Leu Val Lys Ser 
385                 390                 395                 400 


Leu Leu Gly Pro Tyr Leu Val Phe Met Ala Ser Thr Ile Asn Gly Tyr 
                405                 410                 415     


Glu Gly Thr Gly Arg Ser Leu Ser Leu Lys Leu Ile Gln Gln Leu Arg 
            420                 425                 430         


Gln Gln Ser Ala Gln Ser Gln Val Ser Thr Thr Ala Glu Asn Lys Thr 
        435                 440                 445             


Thr Thr Thr Ala Arg Leu Ala Ser Ala Arg Thr Leu His Glu Val Ser 
    450                 455                 460                 


Leu Gln Glu Ser Ile Arg Tyr Ala Pro Gly Asp Ala Val Glu Lys Trp 
465                 470                 475                 480 


Leu Asn Asp Leu Leu Cys Leu Asp Cys Leu Asn Ile Thr Arg Ile Val 
                485                 490                 495     


Ser Gly Cys Pro Leu Pro Glu Ala Cys Glu Leu Tyr Tyr Val Asn Arg 
            500                 505                 510         


Asp Thr Leu Phe Cys Tyr His Lys Ala Ser Glu Val Phe Leu Gln Arg 
        515                 520                 525             


Leu Met Ala Leu Tyr Val Ala Ser His Tyr Lys Asn Ser Pro Asn Asp 
    530                 535                 540                 


Leu Gln Met Leu Ser Asp Ala Pro Ala His His Leu Phe Cys Leu Leu 
545                 550                 555                 560 


Pro Pro Val Pro Pro Thr Gln Asn Ala Leu Pro Glu Val Leu Ala Val 
                565                 570                 575     


Ile Gln Val Cys Leu Glu Gly Glu Ile Ser Arg Gln Ser Ile Leu Asn 
            580                 585                 590         


Ser Leu Ser Arg Gly Lys Lys Ala Ser Gly Asp Leu Ile Pro Trp Thr 
        595                 600                 605             


Val Ser Glu Gln Phe Gln Asp Pro Asp Phe Gly Gly Leu Ser Gly Gly 
    610                 615                 620                 


Arg Val Val Arg Ile Ala Val His Pro Asp Tyr Gln Gly Met Gly Tyr 
625                 630                 635                 640 


Gly Ser Arg Ala Leu Gln Leu Leu Gln Met Tyr Tyr Glu Gly Arg Phe 
                645                 650                 655     


Pro Cys Leu Glu Glu Lys Val Leu Glu Thr Pro Gln Glu Ile His Thr 
            660                 665                 670         


Val Ser Ser Glu Ala Val Ser Leu Leu Glu Glu Val Ile Thr Pro Arg 
        675                 680                 685             


Lys Asp Leu Pro Pro Leu Leu Leu Lys Leu Asn Glu Arg Pro Ala Glu 
    690                 695                 700                 


Arg Leu Asp Tyr Leu Gly Val Ser Tyr Gly Leu Thr Pro Arg Leu Leu 
705                 710                 715                 720 


Lys Phe Trp Lys Arg Ala Gly Phe Val Pro Val Tyr Leu Arg Gln Thr 
                725                 730                 735     


Pro Asn Asp Leu Thr Gly Glu His Ser Cys Ile Met Leu Lys Thr Leu 
            740                 745                 750         


Thr Asp Glu Asp Glu Ala Asp Gln Gly Gly Trp Leu Ala Ala Phe Trp 
        755                 760                 765             


Lys Asp Phe Arg Arg Arg Phe Leu Ala Leu Leu Ser Tyr Gln Phe Ser 
    770                 775                 780                 


Thr Phe Ser Pro Ser Leu Ala Leu Asn Ile Ile Gln Asn Arg Asn Met 
785                 790                 795                 800 


Gly Lys Pro Ala Gln Pro Ala Leu Ser Arg Glu Glu Leu Glu Ala Leu 
                805                 810                 815     


Phe Leu Pro Tyr Asp Leu Lys Arg Leu Glu Met Tyr Ser Arg Asn Met 
            820                 825                 830         


Val Asp Tyr His Leu Ile Met Asp Met Ile Pro Ala Ile Ser Arg Ile 
        835                 840                 845             


Tyr Phe Leu Asn Gln Leu Gly Asp Leu Ala Leu Ser Ala Ala Gln Ser 
    850                 855                 860                 


Ala Leu Leu Leu Gly Ile Gly Leu Gln His Lys Ser Val Asp Gln Leu 
865                 870                 875                 880 


Glu Lys Glu Ile Glu Leu Pro Ser Gly Gln Leu Met Gly Leu Phe Asn 
                885                 890                 895     


Arg Ile Ile Arg Lys Val Val Lys Leu Phe Asn Glu Val Gln Glu Lys 
            900                 905                 910         


Ala Ile Glu Glu Gln Met Val Ala Ala Lys Asp Val Val Met Glu Pro 
        915                 920                 925             


Thr Met Lys Thr Leu Ser Asp Asp Leu Asp Glu Ala Ala Lys Glu Phe 
    930                 935                 940                 


Gln Glu Lys His Lys Lys Glu Val Gly Lys Leu Lys Ser Met Asp Leu 
945                 950                 955                 960 


Ser Glu Tyr Ile Ile Arg Gly Asp Asp Glu Glu Trp Asn Glu Val Leu 
                965                 970                 975     


Asn Lys Ala Gly Pro Asn Ala Ser Ile Ile Ser Leu Lys Ser Asp Lys 
            980                 985                 990         


Lys Arg Lys Leu Glu Ala Lys Gln  Glu Pro Lys Gln Ser  Lys Lys Leu 
        995                 1000                 1005             


Lys Asn  Arg Glu Thr Lys Asn  Lys Lys Asp Met Lys  Leu Lys Arg 
    1010                 1015                 1020             


Lys Lys  
    1025 


<210>  5067
<211>  14507
<212>  PRT
<213>  Homo sapiens

<400>  5067

Met Leu Lys Pro Ser Gly Leu Pro Gly Ser Ser Ser Pro Thr Arg Ser 
1               5                   10                  15      


Leu Met Thr Gly Ser Arg Ser Thr Lys Ala Thr Pro Glu Met Asp Ser 
            20                  25                  30          


Gly Leu Thr Gly Ala Thr Leu Ser Pro Lys Thr Ser Thr Gly Ala Ile 
        35                  40                  45              


Val Val Thr Glu His Thr Leu Pro Phe Thr Ser Pro Asp Lys Thr Leu 
    50                  55                  60                  


Ala Ser Pro Thr Ser Ser Val Val Gly Arg Thr Thr Gln Ser Leu Gly 
65                  70                  75                  80  


Val Met Ser Ser Ala Leu Pro Glu Ser Thr Ser Arg Gly Met Thr His 
                85                  90                  95      


Ser Glu Gln Arg Thr Ser Pro Ser Leu Ser Pro Gln Val Asn Gly Thr 
            100                 105                 110         


Pro Ser Arg Asn Tyr Pro Ala Thr Ser Met Val Ser Gly Leu Ser Ser 
        115                 120                 125             


Pro Arg Thr Arg Thr Ser Ser Thr Glu Gly Asn Phe Thr Lys Glu Ala 
    130                 135                 140                 


Ser Thr Tyr Thr Leu Thr Val Glu Thr Thr Ser Gly Pro Val Thr Glu 
145                 150                 155                 160 


Lys Tyr Thr Val Pro Thr Glu Thr Ser Thr Thr Glu Gly Asp Ser Thr 
                165                 170                 175     


Glu Thr Pro Trp Asp Thr Arg Tyr Ile Pro Val Lys Ile Thr Ser Pro 
            180                 185                 190         


Met Lys Thr Phe Ala Asp Ser Thr Ala Ser Lys Glu Asn Ala Pro Val 
        195                 200                 205             


Ser Met Thr Pro Ala Glu Thr Thr Val Thr Asp Ser His Thr Pro Gly 
    210                 215                 220                 


Arg Thr Asn Pro Ser Phe Gly Thr Leu Tyr Ser Ser Phe Leu Asp Leu 
225                 230                 235                 240 


Ser Pro Lys Gly Thr Pro Asn Ser Arg Gly Glu Thr Ser Leu Glu Leu 
                245                 250                 255     


Ile Leu Ser Thr Thr Gly Tyr Pro Phe Ser Ser Pro Glu Pro Gly Ser 
            260                 265                 270         


Ala Gly His Ser Arg Ile Ser Thr Ser Ala Pro Leu Ser Ser Ser Ala 
        275                 280                 285             


Ser Val Leu Asp Asn Lys Ile Ser Glu Thr Ser Ile Phe Ser Gly Gln 
    290                 295                 300                 


Ser Leu Thr Ser Pro Leu Ser Pro Gly Val Pro Glu Ala Arg Ala Ser 
305                 310                 315                 320 


Thr Met Pro Asn Ser Ala Ile Pro Phe Ser Met Thr Leu Ser Asn Ala 
                325                 330                 335     


Glu Thr Ser Ala Glu Arg Val Arg Ser Thr Ile Ser Ser Leu Gly Thr 
            340                 345                 350         


Pro Ser Ile Ser Thr Lys Gln Thr Ala Glu Thr Ile Leu Thr Phe His 
        355                 360                 365             


Ala Phe Ala Glu Thr Met Asp Ile Pro Ser Thr His Ile Ala Lys Thr 
    370                 375                 380                 


Leu Ala Ser Glu Trp Leu Gly Ser Pro Gly Thr Leu Gly Gly Thr Ser 
385                 390                 395                 400 


Thr Ser Ala Leu Thr Thr Thr Ser Pro Ser Thr Thr Leu Val Ser Glu 
                405                 410                 415     


Glu Thr Asn Thr His His Ser Thr Ser Gly Lys Glu Thr Glu Gly Thr 
            420                 425                 430         


Leu Asn Thr Ser Met Thr Pro Leu Glu Thr Ser Ala Pro Gly Glu Glu 
        435                 440                 445             


Ser Glu Met Thr Ala Thr Leu Val Pro Thr Leu Gly Phe Thr Thr Leu 
    450                 455                 460                 


Asp Ser Lys Ile Arg Ser Pro Ser Gln Val Ser Ser Ser His Pro Thr 
465                 470                 475                 480 


Arg Glu Leu Arg Thr Thr Gly Ser Thr Ser Gly Arg Gln Ser Ser Ser 
                485                 490                 495     


Thr Ala Ala His Gly Ser Ser Asp Ile Leu Arg Ala Thr Thr Ser Ser 
            500                 505                 510         


Thr Ser Lys Ala Ser Ser Trp Thr Ser Glu Ser Thr Ala Gln Gln Phe 
        515                 520                 525             


Ser Glu Pro Gln His Thr Gln Trp Val Glu Thr Ser Pro Ser Met Lys 
    530                 535                 540                 


Thr Glu Arg Pro Pro Ala Ser Thr Ser Val Ala Ala Pro Ile Thr Thr 
545                 550                 555                 560 


Ser Val Pro Ser Val Val Ser Gly Phe Thr Thr Leu Lys Thr Ser Ser 
                565                 570                 575     


Thr Lys Gly Ile Trp Leu Glu Glu Thr Ser Ala Asp Thr Leu Ile Gly 
            580                 585                 590         


Glu Ser Thr Ala Gly Pro Thr Thr His Gln Phe Ala Val Pro Thr Gly 
        595                 600                 605             


Ile Ser Met Thr Gly Gly Ser Ser Thr Arg Gly Ser Gln Gly Thr Thr 
    610                 615                 620                 


His Leu Leu Thr Arg Ala Thr Ala Ser Ser Glu Thr Ser Ala Asp Leu 
625                 630                 635                 640 


Thr Leu Ala Thr Asn Gly Val Pro Val Ser Val Ser Pro Ala Val Ser 
                645                 650                 655     


Lys Thr Ala Ala Gly Ser Ser Pro Pro Gly Gly Thr Lys Pro Ser Tyr 
            660                 665                 670         


Thr Met Val Ser Ser Val Ile Pro Glu Thr Ser Ser Leu Gln Ser Ser 
        675                 680                 685             


Ala Phe Arg Glu Gly Thr Ser Leu Gly Leu Thr Pro Leu Asn Thr Arg 
    690                 695                 700                 


His Pro Phe Ser Ser Pro Glu Pro Asp Ser Ala Gly His Thr Lys Ile 
705                 710                 715                 720 


Ser Thr Ser Ile Pro Leu Leu Ser Ser Ala Ser Val Leu Glu Asp Lys 
                725                 730                 735     


Val Ser Ala Thr Ser Thr Phe Ser His His Lys Ala Thr Ser Ser Ile 
            740                 745                 750         


Thr Thr Gly Thr Pro Glu Ile Ser Thr Lys Thr Lys Pro Ser Ser Ala 
        755                 760                 765             


Val Leu Ser Ser Met Thr Leu Ser Asn Ala Ala Thr Ser Pro Glu Arg 
    770                 775                 780                 


Val Arg Asn Ala Thr Ser Pro Leu Thr His Pro Ser Pro Ser Gly Glu 
785                 790                 795                 800 


Glu Thr Ala Gly Ser Val Leu Thr Leu Ser Thr Ser Ala Glu Thr Thr 
                805                 810                 815     


Asp Ser Pro Asn Ile His Pro Thr Gly Thr Leu Thr Ser Glu Ser Ser 
            820                 825                 830         


Glu Ser Pro Ser Thr Leu Ser Leu Pro Ser Val Ser Gly Val Lys Thr 
        835                 840                 845             


Thr Phe Ser Ser Ser Thr Pro Ser Thr His Leu Phe Thr Ser Gly Glu 
    850                 855                 860                 


Glu Thr Glu Glu Thr Ser Asn Pro Ser Val Ser Gln Pro Glu Thr Ser 
865                 870                 875                 880 


Val Ser Arg Val Arg Thr Thr Leu Ala Ser Thr Ser Val Pro Thr Pro 
                885                 890                 895     


Val Phe Pro Thr Met Asp Thr Trp Pro Thr Arg Ser Ala Gln Phe Ser 
            900                 905                 910         


Ser Ser His Leu Val Ser Glu Leu Arg Ala Thr Ser Ser Thr Ser Val 
        915                 920                 925             


Thr Asn Ser Thr Gly Ser Ala Leu Pro Lys Ile Ser His Leu Thr Gly 
    930                 935                 940                 


Thr Ala Thr Met Ser Gln Thr Asn Arg Asp Thr Phe Asn Asp Ser Ala 
945                 950                 955                 960 


Ala Pro Gln Ser Thr Thr Trp Pro Glu Thr Ser Pro Arg Phe Lys Thr 
                965                 970                 975     


Gly Leu Pro Ser Ala Thr Thr Thr Val Ser Thr Ser Ala Thr Ser Leu 
            980                 985                 990         


Ser Ala Thr Val Met Val Ser Lys  Phe Thr Ser Pro Ala  Thr Ser Ser 
        995                 1000                 1005             


Met Glu  Ala Thr Ser Ile Arg  Glu Pro Ser Thr Thr  Ile Leu Thr 
    1010                 1015                 1020             


Thr Glu  Thr Thr Asn Gly Pro  Gly Ser Met Ala Val  Ala Ser Thr 
    1025                 1030                 1035             


Asn Ile  Pro Ile Gly Lys Gly  Tyr Ile Thr Glu Gly  Arg Leu Asp 
    1040                 1045                 1050             


Thr Ser  His Leu Pro Ile Gly  Thr Thr Ala Ser Ser  Glu Thr Ser 
    1055                 1060                 1065             


Met Asp  Phe Thr Met Ala Lys  Glu Ser Val Ser Met  Ser Val Ser 
    1070                 1075                 1080             


Pro Ser  Gln Ser Met Asp Ala  Ala Gly Ser Ser Thr  Pro Gly Arg 
    1085                 1090                 1095             


Thr Ser  Gln Phe Val Asp Thr  Phe Ser Asp Asp Val  Tyr His Leu 
    1100                 1105                 1110             


Thr Ser  Arg Glu Ile Thr Ile  Pro Arg Asp Gly Thr  Ser Ser Ala 
    1115                 1120                 1125             


Leu Thr  Pro Gln Met Thr Ala  Thr His Pro Pro Ser  Pro Asp Pro 
    1130                 1135                 1140             


Gly Ser  Ala Arg Ser Thr Trp  Leu Gly Ile Leu Ser  Ser Ser Pro 
    1145                 1150                 1155             


Ser Ser  Pro Thr Pro Lys Val  Thr Met Ser Ser Thr  Phe Ser Thr 
    1160                 1165                 1170             


Gln Arg  Val Thr Thr Ser Met  Ile Met Asp Thr Val  Glu Thr Ser 
    1175                 1180                 1185             


Arg Trp  Asn Met Pro Asn Leu  Pro Ser Thr Thr Ser  Leu Thr Pro 
    1190                 1195                 1200             


Ser Asn  Ile Pro Thr Ser Gly  Ala Ile Gly Lys Ser  Thr Leu Val 
    1205                 1210                 1215             


Pro Leu  Asp Thr Pro Ser Pro  Ala Thr Ser Leu Glu  Ala Ser Glu 
    1220                 1225                 1230             


Gly Gly  Leu Pro Thr Leu Ser  Thr Tyr Pro Glu Ser  Thr Asn Thr 
    1235                 1240                 1245             


Pro Ser  Ile His Leu Gly Ala  His Ala Ser Ser Glu  Ser Pro Ser 
    1250                 1255                 1260             


Thr Ile  Lys Leu Thr Met Ala  Ser Val Val Lys Pro  Gly Ser Tyr 
    1265                 1270                 1275             


Thr Pro  Leu Thr Phe Pro Ser  Ile Glu Thr His Ile  His Val Ser 
    1280                 1285                 1290             


Thr Ala  Arg Met Ala Tyr Ser  Ser Gly Ser Ser Pro  Glu Met Thr 
    1295                 1300                 1305             


Ala Pro  Gly Glu Thr Asn Thr  Gly Ser Thr Trp Asp  Pro Thr Thr 
    1310                 1315                 1320             


Tyr Ile  Thr Thr Thr Asp Pro  Lys Asp Thr Ser Ser  Ala Gln Val 
    1325                 1330                 1335             


Ser Thr  Pro His Ser Val Arg  Thr Leu Arg Thr Thr  Glu Asn His 
    1340                 1345                 1350             


Pro Lys  Thr Glu Ser Ala Thr  Pro Ala Ala Tyr Ser  Gly Ser Pro 
    1355                 1360                 1365             


Lys Ile  Ser Ser Ser Pro Asn  Leu Thr Ser Pro Ala  Thr Lys Ala 
    1370                 1375                 1380             


Trp Thr  Ile Thr Asp Thr Thr  Glu His Ser Thr Gln  Leu His Tyr 
    1385                 1390                 1395             


Thr Lys  Leu Ala Glu Lys Ser  Ser Gly Phe Glu Thr  Gln Ser Ala 
    1400                 1405                 1410             


Pro Gly  Pro Val Ser Val Val  Ile Pro Thr Ser Pro  Thr Ile Gly 
    1415                 1420                 1425             


Ser Ser  Thr Leu Glu Leu Thr  Ser Asp Val Pro Gly  Glu Pro Leu 
    1430                 1435                 1440             


Val Leu  Ala Pro Ser Glu Gln  Thr Thr Ile Thr Leu  Pro Met Ala 
    1445                 1450                 1455             


Thr Trp  Leu Ser Thr Ser Leu  Thr Glu Glu Met Ala  Ser Thr Asp 
    1460                 1465                 1470             


Leu Asp  Ile Ser Ser Pro Ser  Ser Pro Met Ser Thr  Phe Ala Ile 
    1475                 1480                 1485             


Phe Pro  Pro Met Ser Thr Pro  Ser His Glu Leu Ser  Lys Ser Glu 
    1490                 1495                 1500             


Ala Asp  Thr Ser Ala Ile Arg  Asn Thr Asp Ser Thr  Thr Leu Asp 
    1505                 1510                 1515             


Gln His  Leu Gly Ile Arg Ser  Leu Gly Arg Thr Gly  Asp Leu Thr 
    1520                 1525                 1530             


Thr Val  Pro Ile Thr Pro Leu  Thr Thr Thr Trp Thr  Ser Val Ile 
    1535                 1540                 1545             


Glu His  Ser Thr Gln Ala Gln  Asp Thr Leu Ser Ala  Thr Met Ser 
    1550                 1555                 1560             


Pro Thr  His Val Thr Gln Ser  Leu Lys Asp Gln Thr  Ser Ile Pro 
    1565                 1570                 1575             


Ala Ser  Ala Ser Pro Ser His  Leu Thr Glu Val Tyr  Pro Glu Leu 
    1580                 1585                 1590             


Gly Thr  Gln Gly Arg Ser Ser  Ser Glu Ala Thr Thr  Phe Trp Lys 
    1595                 1600                 1605             


Pro Ser  Thr Asp Thr Leu Ser  Arg Glu Ile Glu Thr  Gly Pro Thr 
    1610                 1615                 1620             


Asn Ile  Gln Ser Thr Pro Pro  Met Asp Asn Thr Thr  Thr Gly Ser 
    1625                 1630                 1635             


Ser Ser  Ser Gly Val Thr Leu  Gly Ile Ala His Leu  Pro Ile Gly 
    1640                 1645                 1650             


Thr Ser  Ser Pro Ala Glu Thr  Ser Thr Asn Met Ala  Leu Glu Arg 
    1655                 1660                 1665             


Arg Ser  Ser Thr Ala Thr Val  Ser Met Ala Gly Thr  Met Gly Leu 
    1670                 1675                 1680             


Leu Val  Thr Ser Ala Pro Gly  Arg Ser Ile Ser Gln  Ser Leu Gly 
    1685                 1690                 1695             


Arg Val  Ser Ser Val Leu Ser  Glu Ser Thr Thr Glu  Gly Val Thr 
    1700                 1705                 1710             


Asp Ser  Ser Lys Gly Ser Ser  Pro Arg Leu Asn Thr  Gln Gly Asn 
    1715                 1720                 1725             


Thr Ala  Leu Ser Ser Ser Leu  Glu Pro Ser Tyr Ala  Glu Gly Ser 
    1730                 1735                 1740             


Gln Met  Ser Thr Ser Ile Pro  Leu Thr Ser Ser Pro  Thr Thr Pro 
    1745                 1750                 1755             


Asp Val  Glu Phe Ile Gly Gly  Ser Thr Phe Trp Thr  Lys Glu Val 
    1760                 1765                 1770             


Thr Thr  Val Met Thr Ser Asp  Ile Ser Lys Ser Ser  Ala Arg Thr 
    1775                 1780                 1785             


Glu Ser  Ser Ser Ala Thr Leu  Met Ser Thr Ala Leu  Gly Ser Thr 
    1790                 1795                 1800             


Glu Asn  Thr Gly Lys Glu Lys  Leu Arg Thr Ala Ser  Met Asp Leu 
    1805                 1810                 1815             


Pro Ser  Pro Thr Pro Ser Met  Glu Val Thr Pro Trp  Ile Ser Leu 
    1820                 1825                 1830             


Thr Leu  Ser Asn Ala Pro Asn  Thr Thr Asp Ser Leu  Asp Leu Ser 
    1835                 1840                 1845             


His Gly  Val His Thr Ser Ser  Ala Gly Thr Leu Ala  Thr Asp Arg 
    1850                 1855                 1860             


Ser Leu  Asn Thr Gly Val Thr  Arg Ala Ser Arg Leu  Glu Asn Gly 
    1865                 1870                 1875             


Ser Asp  Thr Ser Ser Lys Ser  Leu Ser Met Gly Asn  Ser Thr His 
    1880                 1885                 1890             


Thr Ser  Met Thr Tyr Thr Glu  Lys Ser Glu Val Ser  Ser Ser Ile 
    1895                 1900                 1905             


His Pro  Arg Pro Glu Thr Ser  Ala Pro Gly Ala Glu  Thr Thr Leu 
    1910                 1915                 1920             


Thr Ser  Thr Pro Gly Asn Arg  Ala Ile Ser Leu Thr  Leu Pro Phe 
    1925                 1930                 1935             


Ser Ser  Ile Pro Val Glu Glu  Val Ile Ser Thr Gly  Ile Thr Ser 
    1940                 1945                 1950             


Gly Pro  Asp Ile Asn Ser Ala  Pro Met Thr His Ser  Pro Ile Thr 
    1955                 1960                 1965             


Pro Pro  Thr Ile Val Trp Thr  Ser Thr Gly Thr Ile  Glu Gln Ser 
    1970                 1975                 1980             


Thr Gln  Pro Leu His Ala Val  Ser Ser Glu Lys Val  Ser Val Gln 
    1985                 1990                 1995             


Thr Gln  Ser Thr Pro Tyr Val  Asn Ser Val Ala Val  Ser Ala Ser 
    2000                 2005                 2010             


Pro Thr  His Glu Asn Ser Val  Ser Ser Gly Ser Ser  Thr Ser Ser 
    2015                 2020                 2025             


Pro Tyr  Ser Ser Ala Ser Leu  Glu Ser Leu Asp Ser  Thr Ile Ser 
    2030                 2035                 2040             


Arg Arg  Asn Ala Ile Thr Ser  Trp Leu Trp Asp Leu  Thr Thr Ser 
    2045                 2050                 2055             


Leu Pro  Thr Thr Thr Trp Pro  Ser Thr Ser Leu Ser  Glu Ala Leu 
    2060                 2065                 2070             


Ser Ser  Gly His Ser Gly Val  Ser Asn Pro Ser Ser  Thr Thr Thr 
    2075                 2080                 2085             


Glu Phe  Pro Leu Phe Ser Ala  Ala Ser Thr Ser Ala  Ala Lys Gln 
    2090                 2095                 2100             


Arg Asn  Pro Glu Thr Glu Thr  His Gly Pro Gln Asn  Thr Ala Ala 
    2105                 2110                 2115             


Ser Thr  Leu Asn Thr Asp Ala  Ser Ser Val Thr Gly  Leu Ser Glu 
    2120                 2125                 2130             


Thr Pro  Val Gly Ala Ser Ile  Ser Ser Glu Val Pro  Leu Pro Met 
    2135                 2140                 2145             


Ala Ile  Thr Ser Arg Ser Asp  Val Ser Gly Leu Thr  Ser Glu Ser 
    2150                 2155                 2160             


Thr Ala  Asn Pro Ser Leu Gly  Thr Ala Ser Ser Ala  Gly Thr Lys 
    2165                 2170                 2175             


Leu Thr  Arg Thr Ile Ser Leu  Pro Thr Ser Glu Ser  Leu Val Ser 
    2180                 2185                 2190             


Phe Arg  Met Asn Lys Asp Pro  Trp Thr Val Ser Ile  Pro Leu Gly 
    2195                 2200                 2205             


Ser His  Pro Thr Thr Asn Thr  Glu Thr Ser Ile Pro  Val Asn Ser 
    2210                 2215                 2220             


Ala Gly  Pro Pro Gly Leu Ser  Thr Val Ala Ser Asp  Val Ile Asp 
    2225                 2230                 2235             


Thr Pro  Ser Asp Gly Ala Glu  Ser Ile Pro Thr Val  Ser Phe Ser 
    2240                 2245                 2250             


Pro Ser  Pro Asp Thr Glu Val  Thr Thr Ile Ser His  Phe Pro Glu 
    2255                 2260                 2265             


Lys Thr  Thr His Ser Phe Arg  Thr Ile Ser Ser Leu  Thr His Glu 
    2270                 2275                 2280             


Leu Thr  Ser Arg Val Thr Pro  Ile Pro Gly Asp Trp  Met Ser Ser 
    2285                 2290                 2295             


Ala Met  Ser Thr Lys Pro Thr  Gly Ala Ser Pro Ser  Ile Thr Leu 
    2300                 2305                 2310             


Gly Glu  Arg Arg Thr Ile Thr  Ser Ala Ala Pro Thr  Thr Ser Pro 
    2315                 2320                 2325             


Ile Val  Leu Thr Ala Ser Phe  Thr Glu Thr Ser Thr  Val Ser Leu 
    2330                 2335                 2340             


Asp Asn  Glu Thr Thr Val Lys  Thr Ser Asp Ile Leu  Asp Ala Arg 
    2345                 2350                 2355             


Lys Thr  Asn Glu Leu Pro Ser  Asp Ser Ser Ser Ser  Ser Asp Leu 
    2360                 2365                 2370             


Ile Asn  Thr Ser Ile Ala Ser  Ser Thr Met Asp Val  Thr Lys Thr 
    2375                 2380                 2385             


Ala Ser  Ile Ser Pro Thr Ser  Ile Ser Gly Met Thr  Ala Ser Ser 
    2390                 2395                 2400             


Ser Pro  Ser Leu Phe Ser Ser  Asp Arg Pro Gln Val  Pro Thr Ser 
    2405                 2410                 2415             


Thr Thr  Glu Thr Asn Thr Ala  Thr Ser Pro Ser Val  Ser Ser Asn 
    2420                 2425                 2430             


Thr Tyr  Ser Leu Asp Gly Gly  Ser Asn Val Gly Gly  Thr Pro Ser 
    2435                 2440                 2445             


Thr Leu  Pro Pro Phe Thr Ile  Thr His Pro Val Glu  Thr Ser Ser 
    2450                 2455                 2460             


Ala Leu  Leu Ala Trp Ser Arg  Pro Val Arg Thr Phe  Ser Thr Met 
    2465                 2470                 2475             


Val Ser  Thr Asp Thr Ala Ser  Gly Glu Asn Pro Thr  Ser Ser Asn 
    2480                 2485                 2490             


Ser Val  Val Thr Ser Val Pro  Ala Pro Gly Thr Trp  Thr Ser Val 
    2495                 2500                 2505             


Gly Ser  Thr Thr Asp Leu Pro  Ala Met Gly Phe Leu  Lys Thr Ser 
    2510                 2515                 2520             


Pro Ala  Gly Glu Ala His Ser  Leu Leu Ala Ser Thr  Ile Glu Pro 
    2525                 2530                 2535             


Ala Thr  Ala Phe Thr Pro His  Leu Ser Ala Ala Val  Val Thr Gly 
    2540                 2545                 2550             


Ser Ser  Ala Thr Ser Glu Ala  Ser Leu Leu Thr Thr  Ser Glu Ser 
    2555                 2560                 2565             


Lys Ala  Ile His Ser Ser Pro  Gln Thr Pro Thr Thr  Pro Thr Ser 
    2570                 2575                 2580             


Gly Ala  Asn Trp Glu Thr Ser  Ala Thr Pro Glu Ser  Leu Leu Val 
    2585                 2590                 2595             


Val Thr  Glu Thr Ser Asp Thr  Thr Leu Thr Ser Lys  Ile Leu Val 
    2600                 2605                 2610             


Thr Asp  Thr Ile Leu Phe Ser  Thr Val Ser Thr Pro  Pro Ser Lys 
    2615                 2620                 2625             


Phe Pro  Ser Thr Gly Thr Leu  Ser Gly Ala Ser Phe  Pro Thr Leu 
    2630                 2635                 2640             


Leu Pro  Asp Thr Pro Ala Ile  Pro Leu Thr Ala Thr  Glu Pro Thr 
    2645                 2650                 2655             


Ser Ser  Leu Ala Thr Ser Phe  Asp Ser Thr Pro Leu  Val Thr Ile 
    2660                 2665                 2670             


Ala Ser  Asp Ser Leu Gly Thr  Val Pro Glu Thr Thr  Leu Thr Met 
    2675                 2680                 2685             


Ser Glu  Thr Ser Asn Gly Asp  Ala Leu Val Leu Lys  Thr Val Ser 
    2690                 2695                 2700             


Asn Pro  Asp Arg Ser Ile Pro  Gly Ile Thr Ile Gln  Gly Val Thr 
    2705                 2710                 2715             


Glu Ser  Pro Leu His Pro Ser  Ser Thr Ser Pro Ser  Lys Ile Val 
    2720                 2725                 2730             


Ala Pro  Arg Asn Thr Thr Tyr  Glu Gly Ser Ile Thr  Val Ala Leu 
    2735                 2740                 2745             


Ser Thr  Leu Pro Ala Gly Thr  Thr Gly Ser Leu Val  Phe Ser Gln 
    2750                 2755                 2760             


Ser Ser  Glu Asn Ser Glu Thr  Thr Ala Leu Val Asp  Ser Ser Ala 
    2765                 2770                 2775             


Gly Leu  Glu Arg Ala Ser Val  Met Pro Leu Thr Thr  Gly Ser Gln 
    2780                 2785                 2790             


Gly Met  Ala Ser Ser Gly Gly  Ile Arg Ser Gly Ser  Thr His Ser 
    2795                 2800                 2805             


Thr Gly  Thr Lys Thr Phe Ser  Ser Leu Pro Leu Thr  Met Asn Pro 
    2810                 2815                 2820             


Gly Glu  Val Thr Ala Met Ser  Glu Ile Thr Thr Asn  Arg Leu Thr 
    2825                 2830                 2835             


Ala Thr  Gln Ser Thr Ala Pro  Lys Gly Ile Pro Val  Lys Pro Thr 
    2840                 2845                 2850             


Ser Ala  Glu Ser Gly Leu Leu  Thr Pro Val Ser Ala  Ser Ser Ser 
    2855                 2860                 2865             


Pro Ser  Lys Ala Phe Ala Ser  Leu Thr Thr Ala Pro  Pro Thr Trp 
    2870                 2875                 2880             


Gly Ile  Pro Gln Ser Thr Leu  Thr Phe Glu Phe Ser  Glu Val Pro 
    2885                 2890                 2895             


Ser Leu  Asp Thr Lys Ser Ala  Ser Leu Pro Thr Pro  Gly Gln Ser 
    2900                 2905                 2910             


Leu Asn  Thr Ile Pro Asp Ser  Asp Ala Ser Thr Ala  Ser Ser Ser 
    2915                 2920                 2925             


Leu Ser  Lys Ser Pro Glu Lys  Asn Pro Arg Ala Arg  Met Met Thr 
    2930                 2935                 2940             


Ser Thr  Lys Ala Ile Ser Ala  Ser Ser Phe Gln Ser  Thr Gly Phe 
    2945                 2950                 2955             


Thr Glu  Thr Pro Glu Gly Ser  Ala Ser Pro Ser Met  Ala Gly His 
    2960                 2965                 2970             


Glu Pro  Arg Val Pro Thr Ser  Gly Thr Gly Asp Pro  Arg Tyr Ala 
    2975                 2980                 2985             


Ser Glu  Ser Met Ser Tyr Pro  Asp Pro Ser Lys Ala  Ser Ser Ala 
    2990                 2995                 3000             


Met Thr  Ser Thr Ser Leu Ala  Ser Lys Leu Thr Thr  Leu Phe Ser 
    3005                 3010                 3015             


Thr Gly  Gln Ala Ala Arg Ser  Gly Ser Ser Ser Ser  Pro Ile Ser 
    3020                 3025                 3030             


Leu Ser  Thr Glu Lys Glu Thr  Ser Phe Leu Ser Pro  Thr Ala Ser 
    3035                 3040                 3045             


Thr Ser  Arg Lys Thr Ser Leu  Phe Leu Gly Pro Ser  Met Ala Arg 
    3050                 3055                 3060             


Gln Pro  Asn Ile Leu Val His  Leu Gln Thr Ser Ala  Leu Thr Leu 
    3065                 3070                 3075             


Ser Pro  Thr Ser Thr Leu Asn  Met Ser Gln Glu Glu  Pro Pro Glu 
    3080                 3085                 3090             


Leu Thr  Ser Ser Gln Thr Ile  Ala Glu Glu Glu Gly  Thr Thr Ala 
    3095                 3100                 3105             


Glu Thr  Gln Thr Leu Thr Phe  Thr Pro Ser Glu Thr  Pro Thr Ser 
    3110                 3115                 3120             


Leu Leu  Pro Val Ser Ser Pro  Thr Glu Pro Thr Ala  Arg Arg Lys 
    3125                 3130                 3135             


Ser Ser  Pro Glu Thr Trp Ala  Ser Ser Ile Ser Val  Pro Ala Lys 
    3140                 3145                 3150             


Thr Ser  Leu Val Glu Thr Thr  Asp Gly Thr Leu Val  Thr Thr Ile 
    3155                 3160                 3165             


Lys Met  Ser Ser Gln Ala Ala  Gln Gly Asn Ser Thr  Trp Pro Ala 
    3170                 3175                 3180             


Pro Ala  Glu Glu Thr Gly Ser  Ser Pro Ala Gly Thr  Ser Pro Gly 
    3185                 3190                 3195             


Ser Pro  Glu Met Ser Thr Thr  Leu Lys Ile Met Ser  Ser Lys Glu 
    3200                 3205                 3210             


Pro Ser  Ile Ser Pro Glu Ile  Arg Ser Thr Val Arg  Asn Ser Pro 
    3215                 3220                 3225             


Trp Lys  Thr Pro Glu Thr Thr  Val Pro Met Glu Thr  Thr Val Glu 
    3230                 3235                 3240             


Pro Val  Thr Leu Gln Ser Thr  Ala Leu Gly Ser Gly  Ser Thr Ser 
    3245                 3250                 3255             


Ile Ser  His Leu Pro Thr Gly  Thr Thr Ser Pro Thr  Lys Ser Pro 
    3260                 3265                 3270             


Thr Glu  Asn Met Leu Ala Thr  Glu Arg Val Ser Leu  Ser Pro Ser 
    3275                 3280                 3285             


Pro Pro  Glu Ala Trp Thr Asn  Leu Tyr Ser Gly Thr  Pro Gly Gly 
    3290                 3295                 3300             


Thr Arg  Gln Ser Leu Ala Thr  Met Ser Ser Val Ser  Leu Glu Ser 
    3305                 3310                 3315             


Pro Thr  Ala Arg Ser Ile Thr  Gly Thr Gly Gln Gln  Ser Ser Pro 
    3320                 3325                 3330             


Glu Leu  Val Ser Lys Thr Thr  Gly Met Glu Phe Ser  Met Trp His 
    3335                 3340                 3345             


Gly Ser  Thr Gly Gly Thr Thr  Gly Asp Thr His Val  Ser Leu Ser 
    3350                 3355                 3360             


Thr Ser  Ser Asn Ile Leu Glu  Asp Pro Val Thr Ser  Pro Asn Ser 
    3365                 3370                 3375             


Val Ser  Ser Leu Thr Asp Lys  Ser Lys His Lys Thr  Glu Thr Trp 
    3380                 3385                 3390             


Val Ser  Thr Thr Ala Ile Pro  Ser Thr Val Leu Asn  Asn Lys Ile 
    3395                 3400                 3405             


Met Ala  Ala Glu Gln Gln Thr  Ser Arg Ser Val Asp  Glu Ala Tyr 
    3410                 3415                 3420             


Ser Ser  Thr Ser Ser Trp Ser  Asp Gln Thr Ser Gly  Ser Asp Ile 
    3425                 3430                 3435             


Thr Leu  Gly Ala Ser Pro Asp  Val Thr Asn Thr Leu  Tyr Ile Thr 
    3440                 3445                 3450             


Ser Thr  Ala Gln Thr Thr Ser  Leu Val Ser Leu Pro  Ser Gly Asp 
    3455                 3460                 3465             


Gln Gly  Ile Thr Ser Leu Thr  Asn Pro Ser Gly Gly  Lys Thr Ser 
    3470                 3475                 3480             


Ser Ala  Ser Ser Val Thr Ser  Pro Ser Ile Gly Leu  Glu Thr Leu 
    3485                 3490                 3495             


Arg Ala  Asn Val Ser Ala Val  Lys Ser Asp Ile Ala  Pro Thr Ala 
    3500                 3505                 3510             


Gly His  Leu Ser Gln Thr Ser  Ser Pro Ala Glu Val  Ser Ile Leu 
    3515                 3520                 3525             


Asp Val  Thr Thr Ala Pro Thr  Pro Gly Ile Ser Thr  Thr Ile Thr 
    3530                 3535                 3540             


Thr Met  Gly Thr Asn Ser Ile  Ser Thr Thr Thr Pro  Asn Pro Glu 
    3545                 3550                 3555             


Val Gly  Met Ser Thr Met Asp  Ser Thr Pro Ala Thr  Glu Arg Arg 
    3560                 3565                 3570             


Thr Thr  Ser Thr Glu His Pro  Ser Thr Trp Ser Ser  Thr Ala Ala 
    3575                 3580                 3585             


Ser Asp  Ser Trp Thr Val Thr  Asp Met Thr Ser Asn  Leu Lys Val 
    3590                 3595                 3600             


Ala Arg  Ser Pro Gly Thr Ile  Ser Thr Met His Thr  Thr Ser Phe 
    3605                 3610                 3615             


Leu Ala  Ser Ser Thr Glu Leu  Asp Ser Met Ser Thr  Pro His Gly 
    3620                 3625                 3630             


Arg Ile  Thr Val Ile Gly Thr  Ser Leu Val Thr Pro  Ser Ser Asp 
    3635                 3640                 3645             


Ala Ser  Ala Val Lys Thr Glu  Thr Ser Thr Ser Glu  Arg Thr Leu 
    3650                 3655                 3660             


Ser Pro  Ser Asp Thr Thr Ala  Ser Thr Pro Ile Ser  Thr Phe Ser 
    3665                 3670                 3675             


Arg Val  Gln Arg Met Ser Ile  Ser Val Pro Asp Ile  Leu Ser Thr 
    3680                 3685                 3690             


Ser Trp  Thr Pro Ser Ser Thr  Glu Ala Glu Asp Val  Pro Val Ser 
    3695                 3700                 3705             


Met Val  Ser Thr Asp His Ala  Ser Thr Lys Thr Asp  Pro Asn Thr 
    3710                 3715                 3720             


Pro Leu  Ser Thr Phe Leu Phe  Asp Ser Leu Ser Thr  Leu Asp Trp 
    3725                 3730                 3735             


Asp Thr  Gly Arg Ser Leu Ser  Ser Ala Thr Ala Thr  Thr Ser Ala 
    3740                 3745                 3750             


Pro Gln  Gly Ala Thr Thr Pro  Gln Glu Leu Thr Leu  Glu Thr Met 
    3755                 3760                 3765             


Ile Ser  Pro Ala Thr Ser Gln  Leu Pro Phe Ser Ile  Gly His Ile 
    3770                 3775                 3780             


Thr Ser  Ala Val Thr Pro Ala  Ala Met Ala Arg Ser  Ser Gly Val 
    3785                 3790                 3795             


Thr Phe  Ser Arg Pro Asp Pro  Thr Ser Lys Lys Ala  Glu Gln Thr 
    3800                 3805                 3810             


Ser Thr  Gln Leu Pro Thr Thr  Thr Ser Ala His Pro  Gly Gln Val 
    3815                 3820                 3825             


Pro Arg  Ser Ala Ala Thr Thr  Leu Asp Val Ile Pro  His Thr Ala 
    3830                 3835                 3840             


Lys Thr  Pro Asp Ala Thr Phe  Gln Arg Gln Gly Gln  Thr Ala Leu 
    3845                 3850                 3855             


Thr Thr  Glu Ala Arg Ala Thr  Ser Asp Ser Trp Asn  Glu Lys Glu 
    3860                 3865                 3870             


Lys Ser  Thr Pro Ser Ala Pro  Trp Ile Thr Glu Met  Met Asn Ser 
    3875                 3880                 3885             


Val Ser  Glu Asp Thr Ile Lys  Glu Val Thr Ser Ser  Ser Ser Val 
    3890                 3895                 3900             


Leu Arg  Thr Leu Asn Thr Leu  Asp Ile Asn Leu Glu  Ser Gly Thr 
    3905                 3910                 3915             


Thr Ser  Ser Pro Ser Trp Lys  Ser Ser Pro Tyr Glu  Arg Ile Ala 
    3920                 3925                 3930             


Pro Ser  Glu Ser Thr Thr Asp  Lys Glu Ala Ile His  Pro Ser Thr 
    3935                 3940                 3945             


Asn Thr  Val Glu Thr Thr Gly  Trp Val Thr Ser Ser  Glu His Ala 
    3950                 3955                 3960             


Ser His  Ser Thr Ile Pro Ala  His Ser Ala Ser Ser  Lys Leu Thr 
    3965                 3970                 3975             


Ser Pro  Val Val Thr Thr Ser  Thr Arg Glu Gln Ala  Ile Val Ser 
    3980                 3985                 3990             


Met Ser  Thr Thr Thr Trp Pro  Glu Ser Thr Arg Ala  Arg Thr Glu 
    3995                 4000                 4005             


Pro Asn  Ser Phe Leu Thr Ile  Glu Leu Arg Asp Val  Ser Pro Tyr 
    4010                 4015                 4020             


Met Asp  Thr Ser Ser Thr Thr  Gln Thr Ser Ile Ile  Ser Ser Pro 
    4025                 4030                 4035             


Gly Ser  Thr Ala Ile Thr Lys  Gly Pro Arg Thr Glu  Ile Thr Ser 
    4040                 4045                 4050             


Ser Lys  Arg Ile Ser Ser Ser  Phe Leu Ala Gln Ser  Met Arg Ser 
    4055                 4060                 4065             


Ser Asp  Ser Pro Ser Glu Ala  Ile Thr Arg Leu Ser  Asn Phe Pro 
    4070                 4075                 4080             


Ala Met  Thr Glu Ser Gly Gly  Met Ile Leu Ala Met  Gln Thr Ser 
    4085                 4090                 4095             


Pro Pro  Gly Ala Thr Ser Leu  Ser Ala Pro Thr Leu  Asp Thr Ser 
    4100                 4105                 4110             


Ala Thr  Ala Ser Trp Thr Gly  Thr Pro Leu Ala Thr  Thr Gln Arg 
    4115                 4120                 4125             


Phe Thr  Tyr Ser Glu Lys Thr  Thr Leu Phe Ser Lys  Gly Pro Glu 
    4130                 4135                 4140             


Asp Thr  Ser Gln Pro Ser Pro  Pro Ser Val Glu Glu  Thr Ser Ser 
    4145                 4150                 4155             


Ser Ser  Ser Leu Val Pro Ile  His Ala Thr Thr Ser  Pro Ser Asn 
    4160                 4165                 4170             


Ile Leu  Leu Thr Ser Gln Gly  His Ser Pro Ser Ser  Thr Pro Pro 
    4175                 4180                 4185             


Val Thr  Ser Val Phe Leu Ser  Glu Thr Ser Gly Leu  Gly Lys Thr 
    4190                 4195                 4200             


Thr Asp  Met Ser Arg Ile Ser  Leu Glu Pro Gly Thr  Ser Leu Pro 
    4205                 4210                 4215             


Pro Asn  Leu Ser Ser Thr Ala  Gly Glu Ala Leu Ser  Thr Tyr Glu 
    4220                 4225                 4230             


Ala Ser  Arg Asp Thr Lys Ala  Ile His His Ser Ala  Asp Thr Ala 
    4235                 4240                 4245             


Val Thr  Asn Met Glu Ala Thr  Ser Ser Glu Tyr Ser  Pro Ile Pro 
    4250                 4255                 4260             


Gly His  Thr Lys Pro Ser Lys  Ala Thr Ser Pro Leu  Val Thr Ser 
    4265                 4270                 4275             


His Ile  Met Gly Asp Ile Thr  Ser Ser Thr Ser Val  Phe Gly Ser 
    4280                 4285                 4290             


Ser Glu  Thr Thr Glu Ile Glu  Thr Val Ser Ser Val  Asn Gln Gly 
    4295                 4300                 4305             


Leu Gln  Glu Arg Ser Thr Ser  Gln Val Ala Ser Ser  Ala Thr Glu 
    4310                 4315                 4320             


Thr Ser  Thr Val Ile Thr His  Val Ser Ser Gly Asp  Ala Thr Thr 
    4325                 4330                 4335             


His Val  Thr Lys Thr Gln Ala  Thr Phe Ser Ser Gly  Thr Ser Ile 
    4340                 4345                 4350             


Ser Ser  Pro His Gln Phe Ile  Thr Ser Thr Asn Thr  Phe Thr Asp 
    4355                 4360                 4365             


Val Ser  Thr Asn Pro Ser Thr  Ser Leu Ile Met Thr  Glu Ser Ser 
    4370                 4375                 4380             


Gly Val  Thr Ile Thr Thr Gln  Thr Gly Pro Thr Gly  Ala Ala Thr 
    4385                 4390                 4395             


Gln Gly  Pro Tyr Leu Leu Asp  Thr Ser Thr Met Pro  Tyr Leu Thr 
    4400                 4405                 4410             


Glu Thr  Pro Leu Ala Val Thr  Pro Asp Phe Met Gln  Ser Glu Lys 
    4415                 4420                 4425             


Thr Thr  Leu Ile Ser Lys Gly  Pro Lys Asp Val Ser  Trp Thr Ser 
    4430                 4435                 4440             


Pro Pro  Ser Val Ala Glu Thr  Ser Tyr Pro Ser Ser  Leu Thr Pro 
    4445                 4450                 4455             


Phe Leu  Val Thr Thr Ile Pro  Pro Ala Thr Ser Thr  Leu Gln Gly 
    4460                 4465                 4470             


Gln His  Thr Ser Ser Pro Val  Ser Ala Thr Ser Val  Leu Thr Ser 
    4475                 4480                 4485             


Gly Leu  Val Lys Thr Thr Asp  Met Leu Asn Thr Ser  Met Glu Pro 
    4490                 4495                 4500             


Val Thr  Asn Ser Pro Gln Asn  Leu Asn Asn Pro Ser  Asn Glu Ile 
    4505                 4510                 4515             


Leu Ala  Thr Leu Ala Ala Thr  Thr Asp Ile Glu Thr  Ile His Pro 
    4520                 4525                 4530             


Ser Ile  Asn Lys Ala Val Thr  Asn Met Gly Thr Ala  Ser Ser Ala 
    4535                 4540                 4545             


His Val  Leu His Ser Thr Leu  Pro Val Ser Ser Glu  Pro Ser Thr 
    4550                 4555                 4560             


Ala Thr  Ser Pro Met Val Pro  Ala Ser Ser Met Gly  Asp Ala Leu 
    4565                 4570                 4575             


Ala Ser  Ile Ser Ile Pro Gly  Ser Glu Thr Thr Asp  Ile Glu Gly 
    4580                 4585                 4590             


Glu Pro  Thr Ser Ser Leu Thr  Ala Gly Arg Lys Glu  Asn Ser Thr 
    4595                 4600                 4605             


Leu Gln  Glu Met Asn Ser Thr  Thr Glu Ser Asn Ile  Ile Leu Ser 
    4610                 4615                 4620             


Asn Val  Ser Val Gly Ala Ile  Thr Glu Ala Thr Lys  Met Glu Val 
    4625                 4630                 4635             


Pro Ser  Phe Asp Ala Thr Phe  Ile Pro Thr Pro Ala  Gln Ser Thr 
    4640                 4645                 4650             


Lys Phe  Pro Asp Ile Phe Ser  Val Ala Ser Ser Arg  Leu Ser Asn 
    4655                 4660                 4665             


Ser Pro  Pro Met Thr Ile Ser  Thr His Met Thr Thr  Thr Gln Thr 
    4670                 4675                 4680             


Gly Ser  Ser Gly Ala Thr Ser  Lys Ile Pro Leu Ala  Leu Asp Thr 
    4685                 4690                 4695             


Ser Thr  Leu Glu Thr Ser Ala  Gly Thr Pro Ser Val  Val Thr Glu 
    4700                 4705                 4710             


Gly Phe  Ala His Ser Lys Ile  Thr Thr Ala Met Asn  Asn Asp Val 
    4715                 4720                 4725             


Lys Asp  Val Ser Gln Thr Asn  Pro Pro Phe Gln Asp  Glu Ala Ser 
    4730                 4735                 4740             


Ser Pro  Ser Ser Gln Ala Pro  Val Leu Val Thr Thr  Leu Pro Ser 
    4745                 4750                 4755             


Ser Val  Ala Phe Thr Pro Gln  Trp His Ser Thr Ser  Ser Pro Val 
    4760                 4765                 4770             


Ser Met  Ser Ser Val Leu Thr  Ser Ser Leu Val Lys  Thr Ala Gly 
    4775                 4780                 4785             


Lys Val  Asp Thr Ser Leu Glu  Thr Val Thr Ser Ser  Pro Gln Ser 
    4790                 4795                 4800             


Met Ser  Asn Thr Leu Asp Asp  Ile Ser Val Thr Ser  Ala Ala Thr 
    4805                 4810                 4815             


Thr Asp  Ile Glu Thr Thr His  Pro Ser Ile Asn Thr  Val Val Thr 
    4820                 4825                 4830             


Asn Val  Gly Thr Thr Gly Ser  Ala Phe Glu Ser His  Ser Thr Val 
    4835                 4840                 4845             


Ser Ala  Tyr Pro Glu Pro Ser  Lys Val Thr Ser Pro  Asn Val Thr 
    4850                 4855                 4860             


Thr Ser  Thr Met Glu Asp Thr  Thr Ile Ser Arg Ser  Ile Pro Lys 
    4865                 4870                 4875             


Ser Ser  Lys Thr Thr Arg Thr  Glu Thr Glu Thr Thr  Ser Ser Leu 
    4880                 4885                 4890             


Thr Pro  Lys Leu Arg Glu Thr  Ser Ile Ser Gln Glu  Ile Thr Ser 
    4895                 4900                 4905             


Ser Thr  Glu Thr Ser Thr Val  Pro Tyr Lys Glu Leu  Thr Gly Ala 
    4910                 4915                 4920             


Thr Thr  Glu Val Ser Arg Thr  Asp Val Thr Ser Ser  Ser Ser Thr 
    4925                 4930                 4935             


Ser Phe  Pro Gly Pro Asp Gln  Ser Thr Val Ser Leu  Asp Ile Ser 
    4940                 4945                 4950             


Thr Glu  Thr Asn Thr Arg Leu  Ser Thr Ser Pro Ile  Met Thr Glu 
    4955                 4960                 4965             


Ser Ala  Glu Ile Thr Ile Thr  Thr Gln Thr Gly Pro  His Gly Ala 
    4970                 4975                 4980             


Thr Ser  Gln Asp Thr Phe Thr  Met Asp Pro Ser Asn  Thr Thr Pro 
    4985                 4990                 4995             


Gln Ala  Gly Ile His Ser Ala  Met Thr His Gly Phe  Ser Gln Leu 
    5000                 5005                 5010             


Asp Val  Thr Thr Leu Met Ser  Arg Ile Pro Gln Asp  Val Ser Trp 
    5015                 5020                 5025             


Thr Ser  Pro Pro Ser Val Asp  Lys Thr Ser Ser Pro  Ser Ser Phe 
    5030                 5035                 5040             


Leu Ser  Ser Pro Ala Met Thr  Thr Pro Ser Leu Ile  Ser Ser Thr 
    5045                 5050                 5055             


Leu Pro  Glu Asp Lys Leu Ser  Ser Pro Met Thr Ser  Leu Leu Thr 
    5060                 5065                 5070             


Ser Gly  Leu Val Lys Ile Thr  Asp Ile Leu Arg Thr  Arg Leu Glu 
    5075                 5080                 5085             


Pro Val  Thr Ser Ser Leu Pro  Asn Phe Ser Ser Thr  Ser Asp Lys 
    5090                 5095                 5100             


Ile Leu  Ala Thr Ser Lys Asp  Ser Lys Asp Thr Lys  Glu Ile Phe 
    5105                 5110                 5115             


Pro Ser  Ile Asn Thr Glu Glu  Thr Asn Val Lys Ala  Asn Asn Ser 
    5120                 5125                 5130             


Gly His  Glu Ser His Ser Pro  Ala Leu Ala Asp Ser  Glu Thr Pro 
    5135                 5140                 5145             


Lys Ala  Thr Thr Gln Met Val  Ile Thr Thr Thr Val  Gly Asp Pro 
    5150                 5155                 5160             


Ala Pro  Ser Thr Ser Met Pro  Val His Gly Ser Ser  Glu Thr Thr 
    5165                 5170                 5175             


Asn Ile  Lys Arg Glu Pro Thr  Tyr Phe Leu Thr Pro  Arg Leu Arg 
    5180                 5185                 5190             


Glu Thr  Ser Thr Ser Gln Glu  Ser Ser Phe Pro Thr  Asp Thr Ser 
    5195                 5200                 5205             


Phe Leu  Leu Ser Lys Val Pro  Thr Gly Thr Ile Thr  Glu Val Ser 
    5210                 5215                 5220             


Ser Thr  Gly Val Asn Ser Ser  Ser Lys Ile Ser Thr  Pro Asp His 
    5225                 5230                 5235             


Asp Lys  Ser Thr Val Pro Pro  Asp Thr Phe Thr Gly  Glu Ile Pro 
    5240                 5245                 5250             


Arg Val  Phe Thr Ser Ser Ile  Lys Thr Lys Ser Ala  Glu Met Thr 
    5255                 5260                 5265             


Ile Thr  Thr Gln Ala Ser Pro  Pro Glu Ser Ala Ser  His Ser Thr 
    5270                 5275                 5280             


Leu Pro  Leu Asp Thr Ser Thr  Thr Leu Ser Gln Gly  Gly Thr His 
    5285                 5290                 5295             


Ser Thr  Val Thr Gln Gly Phe  Pro Tyr Ser Glu Val  Thr Thr Leu 
    5300                 5305                 5310             


Met Gly  Met Gly Pro Gly Asn  Val Ser Trp Met Thr  Thr Pro Pro 
    5315                 5320                 5325             


Val Glu  Glu Thr Ser Ser Val  Ser Ser Leu Met Ser  Ser Pro Ala 
    5330                 5335                 5340             


Met Thr  Ser Pro Ser Pro Val  Ser Ser Thr Ser Pro  Gln Ser Ile 
    5345                 5350                 5355             


Pro Ser  Ser Pro Leu Pro Val  Thr Ala Leu Pro Thr  Ser Val Leu 
    5360                 5365                 5370             


Val Thr  Thr Thr Asp Val Leu  Gly Thr Thr Ser Pro  Glu Ser Val 
    5375                 5380                 5385             


Thr Ser  Ser Pro Pro Asn Leu  Ser Ser Ile Thr His  Glu Arg Pro 
    5390                 5395                 5400             


Ala Thr  Tyr Lys Asp Thr Ala  His Thr Glu Ala Ala  Met His His 
    5405                 5410                 5415             


Ser Thr  Asn Thr Ala Val Thr  Asn Val Gly Thr Ser  Gly Ser Gly 
    5420                 5425                 5430             


His Lys  Ser Gln Ser Ser Val  Leu Ala Asp Ser Glu  Thr Ser Lys 
    5435                 5440                 5445             


Ala Thr  Pro Leu Met Ser Thr  Thr Ser Thr Leu Gly  Asp Thr Ser 
    5450                 5455                 5460             


Val Ser  Thr Ser Thr Pro Asn  Ile Ser Gln Thr Asn  Gln Ile Gln 
    5465                 5470                 5475             


Thr Glu  Pro Thr Ala Ser Leu  Ser Pro Arg Leu Arg  Glu Ser Ser 
    5480                 5485                 5490             


Thr Ser  Glu Lys Thr Ser Ser  Thr Thr Glu Thr Asn  Thr Ala Phe 
    5495                 5500                 5505             


Ser Tyr  Val Pro Thr Gly Ala  Ile Thr Gln Ala Ser  Arg Thr Glu 
    5510                 5515                 5520             


Ile Ser  Ser Ser Arg Thr Ser  Ile Ser Asp Leu Asp  Arg Pro Thr 
    5525                 5530                 5535             


Ile Ala  Pro Asp Ile Ser Thr  Gly Met Ile Thr Arg  Leu Phe Thr 
    5540                 5545                 5550             


Ser Pro  Ile Met Thr Lys Ser  Ala Glu Met Thr Val  Thr Thr Gln 
    5555                 5560                 5565             


Thr Thr  Thr Pro Gly Ala Thr  Ser Gln Gly Ile Leu  Pro Trp Asp 
    5570                 5575                 5580             


Thr Ser  Thr Thr Leu Phe Gln  Gly Gly Thr His Ser  Thr Val Ser 
    5585                 5590                 5595             


Gln Gly  Phe Pro His Ser Glu  Ile Thr Thr Leu Arg  Ser Arg Thr 
    5600                 5605                 5610             


Pro Gly  Asp Val Ser Trp Met  Thr Thr Pro Pro Val  Glu Glu Thr 
    5615                 5620                 5625             


Ser Ser  Gly Phe Ser Leu Met  Ser Pro Ser Met Thr  Ser Pro Ser 
    5630                 5635                 5640             


Pro Val  Ser Ser Thr Ser Pro  Glu Ser Ile Pro Ser  Ser Pro Leu 
    5645                 5650                 5655             


Pro Val  Thr Ala Leu Leu Thr  Ser Val Leu Val Thr  Thr Thr Asn 
    5660                 5665                 5670             


Val Leu  Gly Thr Thr Ser Pro  Glu Pro Val Thr Ser  Ser Pro Pro 
    5675                 5680                 5685             


Asn Leu  Ser Ser Pro Thr Gln  Glu Arg Leu Thr Thr  Tyr Lys Asp 
    5690                 5695                 5700             


Thr Ala  His Thr Glu Ala Met  His Ala Ser Met His  Thr Asn Thr 
    5705                 5710                 5715             


Ala Val  Ala Asn Val Gly Thr  Ser Ile Ser Gly His  Glu Ser Gln 
    5720                 5725                 5730             


Ser Ser  Val Pro Ala Asp Ser  His Thr Ser Lys Ala  Thr Ser Pro 
    5735                 5740                 5745             


Met Gly  Ile Thr Phe Ala Met  Gly Asp Thr Ser Val  Ser Thr Ser 
    5750                 5755                 5760             


Thr Pro  Ala Phe Phe Glu Thr  Arg Ile Gln Thr Glu  Ser Thr Ser 
    5765                 5770                 5775             


Ser Leu  Ile Pro Gly Leu Arg  Asp Thr Arg Thr Ser  Glu Glu Ile 
    5780                 5785                 5790             


Asn Thr  Val Thr Glu Thr Ser  Thr Val Leu Ser Glu  Val Pro Thr 
    5795                 5800                 5805             


Thr Thr  Thr Thr Glu Val Ser  Arg Thr Glu Val Ile  Thr Ser Ser 
    5810                 5815                 5820             


Arg Thr  Thr Ile Ser Gly Pro  Asp His Ser Lys Met  Ser Pro Tyr 
    5825                 5830                 5835             


Ile Ser  Thr Glu Thr Ile Thr  Arg Leu Ser Thr Phe  Pro Phe Val 
    5840                 5845                 5850             


Thr Gly  Ser Thr Glu Met Ala  Ile Thr Asn Gln Thr  Gly Pro Ile 
    5855                 5860                 5865             


Gly Thr  Ile Ser Gln Ala Thr  Leu Thr Leu Asp Thr  Ser Ser Thr 
    5870                 5875                 5880             


Ala Ser  Trp Glu Gly Thr His  Ser Pro Val Thr Gln  Arg Phe Pro 
    5885                 5890                 5895             


His Ser  Glu Glu Thr Thr Thr  Met Ser Arg Ser Thr  Lys Gly Val 
    5900                 5905                 5910             


Ser Trp  Gln Ser Pro Pro Ser  Val Glu Glu Thr Ser  Ser Pro Ser 
    5915                 5920                 5925             


Ser Pro  Val Pro Leu Pro Ala  Ile Thr Ser His Ser  Ser Leu Tyr 
    5930                 5935                 5940             


Ser Ala  Val Ser Gly Ser Ser  Pro Thr Ser Ala Leu  Pro Val Thr 
    5945                 5950                 5955             


Ser Leu  Leu Thr Ser Gly Arg  Arg Lys Thr Ile Asp  Met Leu Asp 
    5960                 5965                 5970             


Thr His  Ser Glu Leu Val Thr  Ser Ser Leu Pro Ser  Ala Ser Ser 
    5975                 5980                 5985             


Phe Ser  Gly Glu Ile Leu Thr  Ser Glu Ala Ser Thr  Asn Thr Glu 
    5990                 5995                 6000             


Thr Ile  His Phe Ser Glu Asn  Thr Ala Glu Thr Asn  Met Gly Thr 
    6005                 6010                 6015             


Thr Asn  Ser Met His Lys Leu  His Ser Ser Val Ser  Ile His Ser 
    6020                 6025                 6030             


Gln Pro  Ser Gly His Thr Pro  Pro Lys Val Thr Gly  Ser Met Met 
    6035                 6040                 6045             


Glu Asp  Ala Ile Val Ser Thr  Ser Thr Pro Gly Ser  Pro Glu Thr 
    6050                 6055                 6060             


Lys Asn  Val Asp Arg Asp Ser  Thr Ser Pro Leu Thr  Pro Glu Leu 
    6065                 6070                 6075             


Lys Glu  Asp Ser Thr Ala Leu  Val Met Asn Ser Thr  Thr Glu Ser 
    6080                 6085                 6090             


Asn Thr  Val Phe Ser Ser Val  Ser Leu Asp Ala Ala  Thr Glu Val 
    6095                 6100                 6105             


Ser Arg  Ala Glu Val Thr Tyr  Tyr Asp Pro Thr Phe  Met Pro Ala 
    6110                 6115                 6120             


Ser Ala  Gln Ser Thr Lys Ser  Pro Asp Ile Ser Pro  Glu Ala Ser 
    6125                 6130                 6135             


Ser Ser  His Ser Asn Ser Pro  Pro Leu Thr Ile Ser  Thr His Lys 
    6140                 6145                 6150             


Thr Ile  Ala Thr Gln Thr Gly  Pro Ser Gly Val Thr  Ser Leu Gly 
    6155                 6160                 6165             


Gln Leu  Thr Leu Asp Thr Ser  Thr Ile Ala Thr Ser  Ala Gly Thr 
    6170                 6175                 6180             


Pro Ser  Ala Arg Thr Gln Asp  Phe Val Asp Ser Glu  Thr Thr Ser 
    6185                 6190                 6195             


Val Met  Asn Asn Asp Leu Asn  Asp Val Leu Lys Thr  Ser Pro Phe 
    6200                 6205                 6210             


Ser Ala  Glu Glu Ala Asn Ser  Leu Ser Ser Gln Ala  Pro Leu Leu 
    6215                 6220                 6225             


Val Thr  Thr Ser Pro Ser Pro  Val Thr Ser Thr Leu  Gln Glu His 
    6230                 6235                 6240             


Ser Thr  Ser Ser Leu Val Ser  Val Thr Ser Val Pro  Thr Pro Thr 
    6245                 6250                 6255             


Leu Ala  Lys Ile Thr Asp Met  Asp Thr Asn Leu Glu  Pro Val Thr 
    6260                 6265                 6270             


Arg Ser  Pro Gln Asn Leu Arg  Asn Thr Leu Ala Thr  Ser Glu Ala 
    6275                 6280                 6285             


Thr Thr  Asp Thr His Thr Met  His Pro Ser Ile Asn  Thr Ala Val 
    6290                 6295                 6300             


Ala Asn  Val Gly Thr Thr Ser  Ser Pro Asn Glu Phe  Tyr Phe Thr 
    6305                 6310                 6315             


Val Ser  Pro Asp Ser Asp Pro  Tyr Lys Ala Thr Ser  Ala Val Val 
    6320                 6325                 6330             


Ile Thr  Ser Thr Ser Gly Asp  Ser Ile Val Ser Thr  Ser Met Pro 
    6335                 6340                 6345             


Arg Ser  Ser Ala Met Lys Lys  Ile Glu Ser Glu Thr  Thr Phe Ser 
    6350                 6355                 6360             


Leu Ile  Phe Arg Leu Arg Glu  Thr Ser Thr Ser Gln  Lys Ile Gly 
    6365                 6370                 6375             


Ser Ser  Ser Asp Thr Ser Thr  Val Phe Asp Lys Ala  Phe Thr Ala 
    6380                 6385                 6390             


Ala Thr  Thr Glu Val Ser Arg  Thr Glu Leu Thr Ser  Ser Ser Arg 
    6395                 6400                 6405             


Thr Ser  Ile Gln Gly Thr Glu  Lys Pro Thr Met Ser  Pro Asp Thr 
    6410                 6415                 6420             


Ser Thr  Arg Ser Val Thr Met  Leu Ser Thr Phe Ala  Gly Leu Thr 
    6425                 6430                 6435             


Lys Ser  Glu Glu Arg Thr Ile  Ala Thr Gln Thr Gly  Pro His Arg 
    6440                 6445                 6450             


Ala Thr  Ser Gln Gly Thr Leu  Thr Trp Asp Thr Ser  Ile Thr Thr 
    6455                 6460                 6465             


Ser Gln  Ala Gly Thr His Ser  Ala Met Thr His Gly  Phe Ser Gln 
    6470                 6475                 6480             


Leu Asp  Leu Ser Thr Leu Thr  Ser Arg Val Pro Glu  Tyr Ile Ser 
    6485                 6490                 6495             


Gly Thr  Ser Pro Pro Ser Val  Glu Lys Thr Ser Ser  Ser Ser Ser 
    6500                 6505                 6510             


Leu Leu  Ser Leu Pro Ala Ile  Thr Ser Pro Ser Pro  Val Pro Thr 
    6515                 6520                 6525             


Thr Leu  Pro Glu Ser Arg Pro  Ser Ser Pro Val His  Leu Thr Ser 
    6530                 6535                 6540             


Leu Pro  Thr Ser Gly Leu Val  Lys Thr Thr Asp Met  Leu Ala Ser 
    6545                 6550                 6555             


Val Ala  Ser Leu Pro Pro Asn  Leu Gly Ser Thr Ser  His Lys Ile 
    6560                 6565                 6570             


Pro Thr  Thr Ser Glu Asp Ile  Lys Asp Thr Glu Lys  Met Tyr Pro 
    6575                 6580                 6585             


Ser Thr  Asn Ile Ala Val Thr  Asn Val Gly Thr Thr  Thr Ser Glu 
    6590                 6595                 6600             


Lys Glu  Ser Tyr Ser Ser Val  Pro Ala Tyr Ser Glu  Pro Pro Lys 
    6605                 6610                 6615             


Val Thr  Ser Pro Met Val Thr  Ser Phe Asn Ile Arg  Asp Thr Ile 
    6620                 6625                 6630             


Val Ser  Thr Ser Met Pro Gly  Ser Ser Glu Ile Thr  Arg Ile Glu 
    6635                 6640                 6645             


Met Glu  Ser Thr Phe Ser Leu  Ala His Gly Leu Lys  Gly Thr Ser 
    6650                 6655                 6660             


Thr Ser  Gln Asp Pro Ile Val  Ser Thr Glu Lys Ser  Ala Val Leu 
    6665                 6670                 6675             


His Lys  Leu Thr Thr Gly Ala  Thr Glu Thr Ser Arg  Thr Glu Val 
    6680                 6685                 6690             


Ala Ser  Ser Arg Arg Thr Ser  Ile Pro Gly Pro Asp  His Ser Thr 
    6695                 6700                 6705             


Glu Ser  Pro Asp Ile Ser Thr  Glu Val Ile Pro Ser  Leu Pro Ile 
    6710                 6715                 6720             


Ser Leu  Gly Ile Thr Glu Ser  Ser Asn Met Thr Ile  Ile Thr Arg 
    6725                 6730                 6735             


Thr Gly  Pro Pro Leu Gly Ser  Thr Ser Gln Gly Thr  Phe Thr Leu 
    6740                 6745                 6750             


Asp Thr  Pro Thr Thr Ser Ser  Arg Ala Gly Thr His  Ser Met Ala 
    6755                 6760                 6765             


Thr Gln  Glu Phe Pro His Ser  Glu Met Thr Thr Val  Met Asn Lys 
    6770                 6775                 6780             


Asp Pro  Glu Ile Leu Ser Trp  Thr Ile Pro Pro Ser  Ile Glu Lys 
    6785                 6790                 6795             


Thr Ser  Phe Ser Ser Ser Leu  Met Pro Ser Pro Ala  Met Thr Ser 
    6800                 6805                 6810             


Pro Pro  Val Ser Ser Thr Leu  Pro Lys Thr Ile His  Thr Thr Pro 
    6815                 6820                 6825             


Ser Pro  Met Thr Ser Leu Leu  Thr Pro Ser Leu Val  Met Thr Thr 
    6830                 6835                 6840             


Asp Thr  Leu Gly Thr Ser Pro  Glu Pro Thr Thr Ser  Ser Pro Pro 
    6845                 6850                 6855             


Asn Leu  Ser Ser Thr Ser His  Glu Ile Leu Thr Thr  Asp Glu Asp 
    6860                 6865                 6870             


Thr Thr  Ala Ile Glu Ala Met  His Pro Ser Thr Ser  Thr Ala Ala 
    6875                 6880                 6885             


Thr Asn  Val Glu Thr Thr Ser  Ser Gly His Gly Ser  Gln Ser Ser 
    6890                 6895                 6900             


Val Leu  Ala Asp Ser Glu Lys  Thr Lys Ala Thr Ala  Pro Met Asp 
    6905                 6910                 6915             


Thr Thr  Ser Thr Met Gly His  Thr Thr Val Ser Thr  Ser Met Ser 
    6920                 6925                 6930             


Val Ser  Ser Glu Thr Thr Lys  Ile Lys Arg Glu Ser  Thr Tyr Ser 
    6935                 6940                 6945             


Leu Thr  Pro Gly Leu Arg Glu  Thr Ser Ile Ser Gln  Asn Ala Ser 
    6950                 6955                 6960             


Phe Ser  Thr Asp Thr Ser Ile  Val Leu Ser Glu Val  Pro Thr Gly 
    6965                 6970                 6975             


Thr Thr  Ala Glu Val Ser Arg  Thr Glu Val Thr Ser  Ser Gly Arg 
    6980                 6985                 6990             


Thr Ser  Ile Pro Gly Pro Ser  Gln Ser Thr Val Leu  Pro Glu Ile 
    6995                 7000                 7005             


Ser Thr  Arg Thr Met Thr Arg  Leu Phe Ala Ser Pro  Thr Met Thr 
    7010                 7015                 7020             


Glu Ser  Ala Glu Met Thr Ile  Pro Thr Gln Thr Gly  Pro Ser Gly 
    7025                 7030                 7035             


Ser Thr  Ser Gln Asp Thr Leu  Thr Leu Asp Thr Ser  Thr Thr Lys 
    7040                 7045                 7050             


Ser Gln  Ala Lys Thr His Ser  Thr Leu Thr Gln Arg  Phe Pro His 
    7055                 7060                 7065             


Ser Glu  Met Thr Thr Leu Met  Ser Arg Gly Pro Gly  Asp Met Ser 
    7070                 7075                 7080             


Trp Gln  Ser Ser Pro Ser Leu  Glu Asn Pro Ser Ser  Leu Pro Ser 
    7085                 7090                 7095             


Leu Leu  Ser Leu Pro Ala Thr  Thr Ser Pro Pro Pro  Ile Ser Ser 
    7100                 7105                 7110             


Thr Leu  Pro Val Thr Ile Ser  Ser Ser Pro Leu Pro  Val Thr Ser 
    7115                 7120                 7125             


Leu Leu  Thr Ser Ser Pro Val  Thr Thr Thr Asp Met  Leu His Thr 
    7130                 7135                 7140             


Ser Pro  Glu Leu Val Thr Ser  Ser Pro Pro Lys Leu  Ser His Thr 
    7145                 7150                 7155             


Ser Asp  Glu Arg Leu Thr Thr  Gly Lys Asp Thr Thr  Asn Thr Glu 
    7160                 7165                 7170             


Ala Val  His Pro Ser Thr Asn  Thr Ala Ala Ser Asn  Val Glu Ile 
    7175                 7180                 7185             


Pro Ser  Ser Gly His Glu Ser  Pro Ser Ser Ala Leu  Ala Asp Ser 
    7190                 7195                 7200             


Glu Thr  Ser Lys Ala Thr Ser  Pro Met Phe Ile Thr  Ser Thr Gln 
    7205                 7210                 7215             


Glu Asp  Thr Thr Val Ala Ile  Ser Thr Pro His Phe  Leu Glu Thr 
    7220                 7225                 7230             


Ser Arg  Ile Gln Lys Glu Ser  Ile Ser Ser Leu Ser  Pro Lys Leu 
    7235                 7240                 7245             


Arg Glu  Thr Gly Ser Ser Val  Glu Thr Ser Ser Ala  Ile Glu Thr 
    7250                 7255                 7260             


Ser Ala  Val Leu Ser Glu Val  Ser Ile Gly Ala Thr  Thr Glu Ile 
    7265                 7270                 7275             


Ser Arg  Thr Glu Val Thr Ser  Ser Ser Arg Thr Ser  Ile Ser Gly 
    7280                 7285                 7290             


Ser Ala  Glu Ser Thr Met Leu  Pro Glu Ile Ser Thr  Thr Arg Lys 
    7295                 7300                 7305             


Ile Ile  Lys Phe Pro Thr Ser  Pro Ile Leu Ala Glu  Ser Ser Glu 
    7310                 7315                 7320             


Met Thr  Ile Lys Thr Gln Thr  Ser Pro Pro Gly Ser  Thr Ser Glu 
    7325                 7330                 7335             


Ser Thr  Phe Thr Leu Asp Thr  Ser Thr Thr Pro Ser  Leu Val Ile 
    7340                 7345                 7350             


Thr His  Ser Thr Met Thr Gln  Arg Leu Pro His Ser  Glu Ile Thr 
    7355                 7360                 7365             


Thr Leu  Val Ser Arg Gly Ala  Gly Asp Val Pro Arg  Pro Ser Ser 
    7370                 7375                 7380             


Leu Pro  Val Glu Glu Thr Ser  Pro Pro Ser Ser Gln  Leu Ser Leu 
    7385                 7390                 7395             


Ser Ala  Met Ile Ser Pro Ser  Pro Val Ser Ser Thr  Leu Pro Ala 
    7400                 7405                 7410             


Ser Ser  His Ser Ser Ser Ala  Ser Val Thr Ser Leu  Leu Thr Pro 
    7415                 7420                 7425             


Gly Gln  Val Lys Thr Thr Glu  Val Leu Asp Ala Ser  Ala Glu Pro 
    7430                 7435                 7440             


Glu Thr  Ser Ser Pro Pro Ser  Leu Ser Ser Thr Ser  Val Glu Ile 
    7445                 7450                 7455             


Leu Ala  Thr Ser Glu Val Thr  Thr Asp Thr Glu Lys  Ile His Pro 
    7460                 7465                 7470             


Phe Ser  Asn Thr Ala Val Thr  Lys Val Gly Thr Ser  Ser Ser Gly 
    7475                 7480                 7485             


His Glu  Ser Pro Ser Ser Val  Leu Pro Asp Ser Glu  Thr Thr Lys 
    7490                 7495                 7500             


Ala Thr  Ser Ala Met Gly Thr  Ile Ser Ile Met Gly  Asp Thr Ser 
    7505                 7510                 7515             


Val Ser  Thr Leu Thr Pro Ala  Leu Ser Asn Thr Arg  Lys Ile Gln 
    7520                 7525                 7530             


Ser Glu  Pro Ala Ser Ser Leu  Thr Thr Arg Leu Arg  Glu Thr Ser 
    7535                 7540                 7545             


Thr Ser  Glu Glu Thr Ser Leu  Ala Thr Glu Ala Asn  Thr Val Leu 
    7550                 7555                 7560             


Ser Lys  Val Ser Thr Gly Ala  Thr Thr Glu Val Ser  Arg Thr Glu 
    7565                 7570                 7575             


Ala Ile  Ser Phe Ser Arg Thr  Ser Met Ser Gly Pro  Glu Gln Ser 
    7580                 7585                 7590             


Thr Met  Ser Gln Asp Ile Ser  Ile Gly Thr Ile Pro  Arg Ile Ser 
    7595                 7600                 7605             


Ala Ser  Ser Val Leu Thr Glu  Ser Ala Lys Met Thr  Ile Thr Thr 
    7610                 7615                 7620             


Gln Thr  Gly Pro Ser Glu Ser  Thr Leu Glu Ser Thr  Leu Asn Leu 
    7625                 7630                 7635             


Asn Thr  Ala Thr Thr Pro Ser  Trp Val Glu Thr His  Ser Ile Val 
    7640                 7645                 7650             


Ile Gln  Gly Phe Pro His Pro  Glu Met Thr Thr Ser  Met Gly Arg 
    7655                 7660                 7665             


Gly Pro  Gly Gly Val Ser Trp  Pro Ser Pro Pro Phe  Val Lys Glu 
    7670                 7675                 7680             


Thr Ser  Pro Pro Ser Ser Pro  Leu Ser Leu Pro Ala  Val Thr Ser 
    7685                 7690                 7695             


Pro His  Pro Val Ser Thr Thr  Phe Leu Ala His Ile  Pro Pro Ser 
    7700                 7705                 7710             


Pro Leu  Pro Val Thr Ser Leu  Leu Thr Ser Gly Pro  Ala Thr Thr 
    7715                 7720                 7725             


Thr Asp  Ile Leu Gly Thr Ser  Thr Glu Pro Gly Thr  Ser Ser Ser 
    7730                 7735                 7740             


Ser Ser  Leu Ser Thr Thr Ser  His Glu Arg Leu Thr  Thr Tyr Lys 
    7745                 7750                 7755             


Asp Thr  Ala His Thr Glu Ala  Val His Pro Ser Thr  Asn Thr Gly 
    7760                 7765                 7770             


Gly Thr  Asn Val Ala Thr Thr  Ser Ser Gly Tyr Lys  Ser Gln Ser 
    7775                 7780                 7785             


Ser Val  Leu Ala Asp Ser Ser  Pro Met Cys Thr Thr  Ser Thr Met 
    7790                 7795                 7800             


Gly Asp  Thr Ser Val Leu Thr  Ser Thr Pro Ala Phe  Leu Glu Thr 
    7805                 7810                 7815             


Arg Arg  Ile Gln Thr Glu Leu  Ala Ser Ser Leu Thr  Pro Gly Leu 
    7820                 7825                 7830             


Arg Glu  Ser Ser Gly Ser Glu  Gly Thr Ser Ser Gly  Thr Lys Met 
    7835                 7840                 7845             


Ser Thr  Val Leu Ser Lys Val  Pro Thr Gly Ala Thr  Thr Glu Ile 
    7850                 7855                 7860             


Ser Lys  Glu Asp Val Thr Ser  Ile Pro Gly Pro Ala  Gln Ser Thr 
    7865                 7870                 7875             


Ile Ser  Pro Asp Ile Ser Thr  Arg Thr Val Ser Trp  Phe Ser Thr 
    7880                 7885                 7890             


Ser Pro  Val Met Thr Glu Ser  Ala Glu Ile Thr Met  Asn Thr His 
    7895                 7900                 7905             


Thr Ser  Pro Leu Gly Ala Thr  Thr Gln Gly Thr Ser  Thr Leu Asp 
    7910                 7915                 7920             


Thr Ser  Ser Thr Thr Ser Leu  Thr Met Thr His Ser  Thr Ile Ser 
    7925                 7930                 7935             


Gln Gly  Phe Ser His Ser Gln  Met Ser Thr Leu Met  Arg Arg Gly 
    7940                 7945                 7950             


Pro Glu  Asp Val Ser Trp Met  Ser Pro Pro Leu Leu  Glu Lys Thr 
    7955                 7960                 7965             


Arg Pro  Ser Phe Ser Leu Met  Ser Ser Pro Ala Thr  Thr Ser Pro 
    7970                 7975                 7980             


Ser Pro  Val Ser Ser Thr Leu  Pro Glu Ser Ile Ser  Ser Ser Pro 
    7985                 7990                 7995             


Leu Pro  Val Thr Ser Leu Leu  Thr Ser Gly Leu Ala  Lys Thr Thr 
    8000                 8005                 8010             


Asp Met  Leu His Lys Ser Ser  Glu Pro Val Thr Asn  Ser Pro Ala 
    8015                 8020                 8025             


Asn Leu  Ser Ser Thr Ser Val  Glu Ile Leu Ala Thr  Ser Glu Val 
    8030                 8035                 8040             


Thr Thr  Asp Thr Glu Lys Thr  His Pro Ser Ser Asn  Arg Thr Val 
    8045                 8050                 8055             


Thr Asp  Val Gly Thr Ser Ser  Ser Gly His Glu Ser  Thr Ser Phe 
    8060                 8065                 8070             


Val Leu  Ala Asp Ser Gln Thr  Ser Lys Val Thr Ser  Pro Met Val 
    8075                 8080                 8085             


Ile Thr  Ser Thr Met Glu Asp  Thr Ser Val Ser Thr  Ser Thr Pro 
    8090                 8095                 8100             


Gly Phe  Phe Glu Thr Ser Arg  Ile Gln Thr Glu Pro  Thr Ser Ser 
    8105                 8110                 8115             


Leu Thr  Leu Gly Leu Arg Lys  Thr Ser Ser Ser Glu  Gly Thr Ser 
    8120                 8125                 8130             


Leu Ala  Thr Glu Met Ser Thr  Val Leu Ser Gly Val  Pro Thr Gly 
    8135                 8140                 8145             


Ala Thr  Ala Glu Val Ser Arg  Thr Glu Val Thr Ser  Ser Ser Arg 
    8150                 8155                 8160             


Thr Ser  Ile Ser Gly Phe Ala  Gln Leu Thr Val Ser  Pro Glu Thr 
    8165                 8170                 8175             


Ser Thr  Glu Thr Ile Thr Arg  Leu Pro Thr Ser Ser  Ile Met Thr 
    8180                 8185                 8190             


Glu Ser  Ala Glu Met Met Ile  Lys Thr Gln Thr Asp  Pro Pro Gly 
    8195                 8200                 8205             


Ser Thr  Pro Glu Ser Thr His  Thr Val Asp Ile Ser  Thr Thr Pro 
    8210                 8215                 8220             


Asn Trp  Val Glu Thr His Ser  Thr Val Thr Gln Arg  Phe Ser His 
    8225                 8230                 8235             


Ser Glu  Met Thr Thr Leu Val  Ser Arg Ser Pro Gly  Asp Met Leu 
    8240                 8245                 8250             


Trp Pro  Ser Gln Ser Ser Val  Glu Glu Thr Ser Ser  Ala Ser Ser 
    8255                 8260                 8265             


Leu Leu  Ser Leu Pro Ala Thr  Thr Ser Pro Ser Pro  Val Ser Ser 
    8270                 8275                 8280             


Thr Leu  Val Glu Asp Phe Pro  Ser Ala Ser Leu Pro  Val Thr Ser 
    8285                 8290                 8295             


Leu Leu  Asn Pro Gly Leu Val  Ile Thr Thr Asp Arg  Met Gly Ile 
    8300                 8305                 8310             


Ser Arg  Glu Pro Gly Thr Ser  Ser Thr Ser Asn Leu  Ser Ser Thr 
    8315                 8320                 8325             


Ser His  Glu Arg Leu Thr Thr  Leu Glu Asp Thr Val  Asp Thr Glu 
    8330                 8335                 8340             


Asp Met  Gln Pro Ser Thr His  Thr Ala Val Thr Asn  Val Arg Thr 
    8345                 8350                 8355             


Ser Ile  Ser Gly His Glu Ser  Gln Ser Ser Val Leu  Ser Asp Ser 
    8360                 8365                 8370             


Glu Thr  Pro Lys Ala Thr Ser  Pro Met Gly Thr Thr  Tyr Thr Met 
    8375                 8380                 8385             


Gly Glu  Thr Ser Val Ser Ile  Ser Thr Ser Asp Phe  Phe Glu Thr 
    8390                 8395                 8400             


Ser Arg  Ile Gln Ile Glu Pro  Thr Ser Ser Leu Thr  Ser Gly Leu 
    8405                 8410                 8415             


Arg Glu  Thr Ser Ser Ser Glu  Arg Ile Ser Ser Ala  Thr Glu Gly 
    8420                 8425                 8430             


Ser Thr  Val Leu Ser Glu Val  Pro Ser Gly Ala Thr  Thr Glu Val 
    8435                 8440                 8445             


Ser Arg  Thr Glu Val Ile Ser  Ser Arg Gly Thr Ser  Met Ser Gly 
    8450                 8455                 8460             


Pro Asp  Gln Phe Thr Ile Ser  Pro Asp Ile Ser Thr  Glu Ala Ile 
    8465                 8470                 8475             


Thr Arg  Leu Ser Thr Ser Pro  Ile Met Thr Glu Ser  Ala Glu Ser 
    8480                 8485                 8490             


Ala Ile  Thr Ile Glu Thr Gly  Ser Pro Gly Ala Thr  Ser Glu Gly 
    8495                 8500                 8505             


Thr Leu  Thr Leu Asp Thr Ser  Thr Thr Thr Phe Trp  Ser Gly Thr 
    8510                 8515                 8520             


His Ser  Thr Ala Ser Pro Gly  Phe Ser His Ser Glu  Met Thr Thr 
    8525                 8530                 8535             


Leu Met  Ser Arg Thr Pro Gly  Asp Val Pro Trp Pro  Ser Leu Pro 
    8540                 8545                 8550             


Ser Val  Glu Glu Ala Ser Ser  Val Ser Ser Ser Leu  Ser Ser Pro 
    8555                 8560                 8565             


Ala Met  Thr Ser Thr Ser Phe  Phe Ser Thr Leu Pro  Glu Ser Ile 
    8570                 8575                 8580             


Ser Ser  Ser Pro His Pro Val  Thr Ala Leu Leu Thr  Leu Gly Pro 
    8585                 8590                 8595             


Val Lys  Thr Thr Asp Met Leu  Arg Thr Ser Ser Glu  Pro Glu Thr 
    8600                 8605                 8610             


Ser Ser  Pro Pro Asn Leu Ser  Ser Thr Ser Ala Glu  Ile Leu Ala 
    8615                 8620                 8625             


Thr Ser  Glu Val Thr Lys Asp  Arg Glu Lys Ile His  Pro Ser Ser 
    8630                 8635                 8640             


Asn Thr  Pro Val Val Asn Val  Gly Thr Val Ile Tyr  Lys His Leu 
    8645                 8650                 8655             


Ser Pro  Ser Ser Val Leu Ala  Asp Leu Val Thr Thr  Lys Pro Thr 
    8660                 8665                 8670             


Ser Pro  Met Ala Thr Thr Ser  Thr Leu Gly Asn Thr  Ser Val Ser 
    8675                 8680                 8685             


Thr Ser  Thr Pro Ala Phe Pro  Glu Thr Met Met Thr  Gln Pro Thr 
    8690                 8695                 8700             


Ser Ser  Leu Thr Ser Gly Leu  Arg Glu Ile Ser Thr  Ser Gln Glu 
    8705                 8710                 8715             


Thr Ser  Ser Ala Thr Glu Arg  Ser Ala Ser Leu Ser  Gly Met Pro 
    8720                 8725                 8730             


Thr Gly  Ala Thr Thr Lys Val  Ser Arg Thr Glu Ala  Leu Ser Leu 
    8735                 8740                 8745             


Gly Arg  Thr Ser Thr Pro Gly  Pro Ala Gln Ser Thr  Ile Ser Pro 
    8750                 8755                 8760             


Glu Ile  Ser Thr Glu Thr Ile  Thr Arg Ile Ser Thr  Pro Leu Thr 
    8765                 8770                 8775             


Thr Thr  Gly Ser Ala Glu Met  Thr Ile Thr Pro Lys  Thr Gly His 
    8780                 8785                 8790             


Ser Gly  Ala Ser Ser Gln Gly  Thr Phe Thr Leu Asp  Thr Ser Ser 
    8795                 8800                 8805             


Arg Ala  Ser Trp Pro Gly Thr  His Ser Ala Ala Thr  His Arg Ser 
    8810                 8815                 8820             


Pro His  Ser Gly Met Thr Thr  Pro Met Ser Arg Gly  Pro Glu Asp 
    8825                 8830                 8835             


Val Ser  Trp Pro Ser Arg Pro  Ser Val Glu Lys Thr  Ser Pro Pro 
    8840                 8845                 8850             


Ser Ser  Leu Val Ser Leu Ser  Ala Val Thr Ser Pro  Ser Pro Leu 
    8855                 8860                 8865             


Tyr Ser  Thr Pro Ser Glu Ser  Ser His Ser Ser Pro  Leu Arg Val 
    8870                 8875                 8880             


Thr Ser  Leu Phe Thr Pro Val  Met Met Lys Thr Thr  Asp Met Leu 
    8885                 8890                 8895             


Asp Thr  Ser Leu Glu Pro Val  Thr Thr Ser Pro Pro  Ser Met Asn 
    8900                 8905                 8910             


Ile Thr  Ser Asp Glu Ser Leu  Ala Thr Ser Lys Ala  Thr Met Glu 
    8915                 8920                 8925             


Thr Glu  Ala Ile Gln Leu Ser  Glu Asn Thr Ala Val  Thr Gln Met 
    8930                 8935                 8940             


Gly Thr  Ile Ser Ala Arg Gln  Glu Phe Tyr Ser Ser  Tyr Pro Gly 
    8945                 8950                 8955             


Leu Pro  Glu Pro Ser Lys Val  Thr Ser Pro Val Val  Thr Ser Ser 
    8960                 8965                 8970             


Thr Ile  Lys Asp Ile Val Ser  Thr Thr Ile Pro Ala  Ser Ser Glu 
    8975                 8980                 8985             


Ile Thr  Arg Ile Glu Met Glu  Ser Thr Ser Thr Leu  Thr Pro Thr 
    8990                 8995                 9000             


Pro Arg  Glu Thr Ser Thr Ser  Gln Glu Ile His Ser  Ala Thr Lys 
    9005                 9010                 9015             


Pro Ser  Thr Val Pro Tyr Lys  Ala Leu Thr Ser Ala  Thr Ile Glu 
    9020                 9025                 9030             


Asp Ser  Met Thr Gln Val Met  Ser Ser Ser Arg Gly  Pro Ser Pro 
    9035                 9040                 9045             


Asp Gln  Ser Thr Met Ser Gln  Asp Ile Ser Thr Glu  Val Ile Thr 
    9050                 9055                 9060             


Arg Leu  Ser Thr Ser Pro Ile  Lys Thr Glu Ser Thr  Glu Met Thr 
    9065                 9070                 9075             


Ile Thr  Thr Gln Thr Gly Ser  Pro Gly Ala Thr Ser  Arg Gly Thr 
    9080                 9085                 9090             


Leu Thr  Leu Asp Thr Ser Thr  Thr Phe Met Ser Gly  Thr His Ser 
    9095                 9100                 9105             


Thr Ala  Ser Gln Gly Phe Ser  His Ser Gln Met Thr  Ala Leu Met 
    9110                 9115                 9120             


Ser Arg  Thr Pro Gly Asp Val  Pro Trp Leu Ser His  Pro Ser Val 
    9125                 9130                 9135             


Glu Glu  Ala Ser Ser Ala Ser  Phe Ser Leu Ser Ser  Pro Val Met 
    9140                 9145                 9150             


Thr Ser  Ser Ser Pro Val Ser  Ser Thr Leu Pro Asp  Ser Ile His 
    9155                 9160                 9165             


Ser Ser  Ser Leu Pro Val Thr  Ser Leu Leu Thr Ser  Gly Leu Val 
    9170                 9175                 9180             


Lys Thr  Thr Glu Leu Leu Gly  Thr Ser Ser Glu Pro  Glu Thr Ser 
    9185                 9190                 9195             


Ser Pro  Pro Asn Leu Ser Ser  Thr Ser Ala Glu Ile  Leu Ala Ile 
    9200                 9205                 9210             


Thr Glu  Val Thr Thr Asp Thr  Glu Lys Leu Glu Met  Thr Asn Val 
    9215                 9220                 9225             


Val Thr  Ser Gly Tyr Thr His  Glu Ser Pro Ser Ser  Val Leu Ala 
    9230                 9235                 9240             


Asp Ser  Val Thr Thr Lys Ala  Thr Ser Ser Met Gly  Ile Thr Tyr 
    9245                 9250                 9255             


Pro Thr  Gly Asp Thr Asn Val  Leu Thr Ser Thr Pro  Ala Phe Ser 
    9260                 9265                 9270             


Asp Thr  Ser Arg Ile Gln Thr  Lys Ser Lys Leu Ser  Leu Thr Pro 
    9275                 9280                 9285             


Gly Leu  Met Glu Thr Ser Ile  Ser Glu Glu Thr Ser  Ser Ala Thr 
    9290                 9295                 9300             


Glu Lys  Ser Thr Val Leu Ser  Ser Val Pro Thr Gly  Ala Thr Thr 
    9305                 9310                 9315             


Glu Val  Ser Arg Thr Glu Ala  Ile Ser Ser Ser Arg  Thr Ser Ile 
    9320                 9325                 9330             


Pro Gly  Pro Ala Gln Ser Thr  Met Ser Ser Asp Thr  Ser Met Glu 
    9335                 9340                 9345             


Thr Ile  Thr Arg Ile Ser Thr  Pro Leu Thr Arg Lys  Glu Ser Thr 
    9350                 9355                 9360             


Asp Met  Ala Ile Thr Pro Lys  Thr Gly Pro Ser Gly  Ala Thr Ser 
    9365                 9370                 9375             


Gln Gly  Thr Phe Thr Leu Asp  Ser Ser Ser Thr Ala  Ser Trp Pro 
    9380                 9385                 9390             


Gly Thr  His Ser Ala Thr Thr  Gln Arg Phe Pro Gln  Ser Val Val 
    9395                 9400                 9405             


Thr Thr  Pro Met Ser Arg Gly  Pro Glu Asp Val Ser  Trp Pro Ser 
    9410                 9415                 9420             


Pro Leu  Ser Val Glu Lys Asn  Ser Pro Pro Ser Ser  Leu Val Ser 
    9425                 9430                 9435             


Ser Ser  Ser Val Thr Ser Pro  Ser Pro Leu Tyr Ser  Thr Pro Ser 
    9440                 9445                 9450             


Gly Ser  Ser His Ser Ser Pro  Val Pro Val Thr Ser  Leu Phe Thr 
    9455                 9460                 9465             


Ser Ile  Met Met Lys Ala Thr  Asp Met Leu Asp Ala  Ser Leu Glu 
    9470                 9475                 9480             


Pro Glu  Thr Thr Ser Ala Pro  Asn Met Asn Ile Thr  Ser Asp Glu 
    9485                 9490                 9495             


Ser Leu  Ala Ala Ser Lys Ala  Thr Thr Glu Thr Glu  Ala Ile His 
    9500                 9505                 9510             


Val Phe  Glu Asn Thr Ala Ala  Ser His Val Glu Thr  Thr Ser Ala 
    9515                 9520                 9525             


Thr Glu  Glu Leu Tyr Ser Ser  Ser Pro Gly Phe Ser  Glu Pro Thr 
    9530                 9535                 9540             


Lys Val  Ile Ser Pro Val Val  Thr Ser Ser Ser Ile  Arg Asp Asn 
    9545                 9550                 9555             


Met Val  Ser Thr Thr Met Pro  Gly Ser Ser Gly Ile  Thr Arg Ile 
    9560                 9565                 9570             


Glu Ile  Glu Ser Met Ser Ser  Leu Thr Pro Gly Leu  Arg Glu Thr 
    9575                 9580                 9585             


Arg Thr  Ser Gln Asp Ile Thr  Ser Ser Thr Glu Thr  Ser Thr Val 
    9590                 9595                 9600             


Leu Tyr  Lys Met Pro Ser Gly  Ala Thr Pro Glu Val  Ser Arg Thr 
    9605                 9610                 9615             


Glu Val  Met Pro Ser Ser Arg  Thr Ser Ile Pro Gly  Pro Ala Gln 
    9620                 9625                 9630             


Ser Thr  Met Ser Leu Asp Ile  Ser Asp Glu Val Val  Thr Arg Leu 
    9635                 9640                 9645             


Ser Thr  Ser Pro Ile Met Thr  Glu Ser Ala Glu Ile  Thr Ile Thr 
    9650                 9655                 9660             


Thr Gln  Thr Gly Tyr Ser Leu  Ala Thr Ser Gln Val  Thr Leu Pro 
    9665                 9670                 9675             


Leu Gly  Thr Ser Met Thr Phe  Leu Ser Gly Thr His  Ser Thr Met 
    9680                 9685                 9690             


Ser Gln  Gly Leu Ser His Ser  Glu Met Thr Asn Leu  Met Ser Arg 
    9695                 9700                 9705             


Gly Pro  Glu Ser Leu Ser Trp  Thr Ser Pro Arg Phe  Val Glu Thr 
    9710                 9715                 9720             


Thr Arg  Ser Ser Ser Ser Leu  Thr Ser Leu Pro Leu  Thr Thr Ser 
    9725                 9730                 9735             


Leu Ser  Pro Val Ser Ser Thr  Leu Leu Asp Ser Ser  Pro Ser Ser 
    9740                 9745                 9750             


Pro Leu  Pro Val Thr Ser Leu  Ile Leu Pro Gly Leu  Val Lys Thr 
    9755                 9760                 9765             


Thr Glu  Val Leu Asp Thr Ser  Ser Glu Pro Lys Thr  Ser Ser Ser 
    9770                 9775                 9780             


Pro Asn  Leu Ser Ser Thr Ser  Val Glu Ile Pro Ala  Thr Ser Glu 
    9785                 9790                 9795             


Ile Met  Thr Asp Thr Glu Lys  Ile His Pro Ser Ser  Asn Thr Ala 
    9800                 9805                 9810             


Val Ala  Lys Val Arg Thr Ser  Ser Ser Val His Glu  Ser His Ser 
    9815                 9820                 9825             


Ser Val  Leu Ala Asp Ser Glu  Thr Thr Ile Thr Ile  Pro Ser Met 
    9830                 9835                 9840             


Gly Ile  Thr Ser Ala Val Asp  Asp Thr Thr Val Phe  Thr Ser Asn 
    9845                 9850                 9855             


Pro Ala  Phe Ser Glu Thr Arg  Arg Ile Pro Thr Glu  Pro Thr Phe 
    9860                 9865                 9870             


Ser Leu  Thr Pro Gly Phe Arg  Glu Thr Ser Thr Ser  Glu Glu Thr 
    9875                 9880                 9885             


Thr Ser  Ile Thr Glu Thr Ser  Ala Val Leu Tyr Gly  Val Pro Thr 
    9890                 9895                 9900             


Ser Ala  Thr Thr Glu Val Ser  Met Thr Glu Ile Met  Ser Ser Asn 
    9905                 9910                 9915             


Arg Ile  His Ile Pro Asp Ser  Asp Gln Ser Thr Met  Ser Pro Asp 
    9920                 9925                 9930             


Ile Ile  Thr Glu Val Ile Thr  Arg Leu Ser Ser Ser  Ser Met Met 
    9935                 9940                 9945             


Ser Glu  Ser Thr Gln Met Thr  Ile Thr Thr Gln Lys  Ser Ser Pro 
    9950                 9955                 9960             


Gly Ala  Thr Ala Gln Ser Thr  Leu Thr Leu Ala Thr  Thr Thr Ala 
    9965                 9970                 9975             


Pro Leu  Ala Arg Thr His Ser  Thr Val Pro Pro Arg  Phe Leu His 
    9980                 9985                 9990             


Ser Glu  Met Thr Thr Leu Met   Ser Arg Ser Pro Glu   Asn Pro Ser 
    9995                 10000                 10005             


Trp Lys   Ser Ser Leu Phe Val   Glu Lys Thr Ser Ser   Ser Ser Ser 
    10010                 10015                 10020             


Leu Leu   Ser Leu Pro Val Thr   Thr Ser Pro Ser Val   Ser Ser Thr 
    10025                 10030                 10035             


Leu Pro   Gln Ser Ile Pro Ser   Ser Ser Phe Ser Val   Thr Ser Leu 
    10040                 10045                 10050             


Leu Thr   Pro Gly Met Val Lys   Thr Thr Asp Thr Ser   Thr Glu Pro 
    10055                 10060                 10065             


Gly Thr   Ser Leu Ser Pro Asn   Leu Ser Gly Thr Ser   Val Glu Ile 
    10070                 10075                 10080             


Leu Ala   Ala Ser Glu Val Thr   Thr Asp Thr Glu Lys   Ile His Pro 
    10085                 10090                 10095             


Ser Ser   Ser Met Ala Val Thr   Asn Val Gly Thr Thr   Ser Ser Gly 
    10100                 10105                 10110             


His Glu   Leu Tyr Ser Ser Val   Ser Ile His Ser Glu   Pro Ser Lys 
    10115                 10120                 10125             


Ala Thr   Tyr Pro Val Gly Thr   Pro Ser Ser Met Ala   Glu Thr Ser 
    10130                 10135                 10140             


Ile Ser   Thr Ser Met Pro Ala   Asn Phe Glu Thr Thr   Gly Phe Glu 
    10145                 10150                 10155             


Ala Glu   Pro Phe Ser His Leu   Thr Ser Gly Phe Arg   Lys Thr Asn 
    10160                 10165                 10170             


Met Ser   Leu Asp Thr Ser Ser   Val Thr Pro Thr Asn   Thr Pro Ser 
    10175                 10180                 10185             


Ser Pro   Gly Ser Thr His Leu   Leu Gln Ser Ser Lys   Thr Asp Phe 
    10190                 10195                 10200             


Thr Ser   Ser Ala Lys Thr Ser   Ser Pro Asp Trp Pro   Pro Ala Ser 
    10205                 10210                 10215             


Gln Tyr   Thr Glu Ile Pro Val   Asp Ile Ile Thr Pro   Phe Asn Ala 
    10220                 10225                 10230             


Ser Pro   Ser Ile Thr Glu Ser   Thr Gly Ile Thr Ser   Phe Pro Glu 
    10235                 10240                 10245             


Ser Arg   Phe Thr Met Ser Val   Thr Glu Ser Thr His   His Leu Ser 
    10250                 10255                 10260             


Thr Asp   Leu Leu Pro Ser Ala   Glu Thr Ile Ser Thr   Gly Thr Val 
    10265                 10270                 10275             


Met Pro   Ser Leu Ser Glu Ala   Met Thr Ser Phe Ala   Thr Thr Gly 
    10280                 10285                 10290             


Val Pro   Arg Ala Ile Ser Gly   Ser Gly Ser Pro Phe   Ser Arg Thr 
    10295                 10300                 10305             


Glu Ser   Gly Pro Gly Asp Ala   Thr Leu Ser Thr Ile   Ala Glu Ser 
    10310                 10315                 10320             


Leu Pro   Ser Ser Thr Pro Val   Pro Phe Ser Ser Ser   Thr Phe Thr 
    10325                 10330                 10335             


Thr Thr   Asp Ser Ser Thr Ile   Pro Ala Leu His Glu   Ile Thr Ser 
    10340                 10345                 10350             


Ser Ser   Ala Thr Pro Tyr Arg   Val Asp Thr Ser Leu   Gly Thr Glu 
    10355                 10360                 10365             


Ser Ser   Thr Thr Glu Gly Arg   Leu Val Met Val Ser   Thr Leu Asp 
    10370                 10375                 10380             


Thr Ser   Ser Gln Pro Gly Arg   Thr Ser Ser Ser Pro   Ile Leu Asp 
    10385                 10390                 10395             


Thr Arg   Met Thr Glu Ser Val   Glu Leu Gly Thr Val   Thr Ser Ala 
    10400                 10405                 10410             


Tyr Gln   Val Pro Ser Leu Ser   Thr Arg Leu Thr Arg   Thr Asp Gly 
    10415                 10420                 10425             


Ile Met   Glu His Ile Thr Lys   Ile Pro Asn Glu Ala   Ala His Arg 
    10430                 10435                 10440             


Gly Thr   Ile Arg Pro Val Lys   Gly Pro Gln Thr Ser   Thr Ser Pro 
    10445                 10450                 10455             


Ala Ser   Pro Lys Gly Leu His   Thr Gly Gly Thr Lys   Arg Met Glu 
    10460                 10465                 10470             


Thr Thr   Thr Thr Ala Leu Lys   Thr Thr Thr Thr Ala   Leu Lys Thr 
    10475                 10480                 10485             


Thr Ser   Arg Ala Thr Leu Thr   Thr Ser Val Tyr Thr   Pro Thr Leu 
    10490                 10495                 10500             


Gly Thr   Leu Thr Pro Leu Asn   Ala Ser Met Gln Met   Ala Ser Thr 
    10505                 10510                 10515             


Ile Pro   Thr Glu Met Met Ile   Thr Thr Pro Tyr Val   Phe Pro Asp 
    10520                 10525                 10530             


Val Pro   Glu Thr Thr Ser Ser   Leu Ala Thr Ser Leu   Gly Ala Glu 
    10535                 10540                 10545             


Thr Ser   Thr Ala Leu Pro Arg   Thr Thr Pro Ser Val   Phe Asn Arg 
    10550                 10555                 10560             


Glu Ser   Glu Thr Thr Ala Ser   Leu Val Ser Arg Ser   Gly Ala Glu 
    10565                 10570                 10575             


Arg Ser   Pro Val Ile Gln Thr   Leu Asp Val Ser Ser   Ser Glu Pro 
    10580                 10585                 10590             


Asp Thr   Thr Ala Ser Trp Val   Ile His Pro Ala Glu   Thr Ile Pro 
    10595                 10600                 10605             


Thr Val   Ser Lys Thr Thr Pro   Asn Phe Phe His Ser   Glu Leu Asp 
    10610                 10615                 10620             


Thr Val   Ser Ser Thr Ala Thr   Ser His Gly Ala Asp   Val Ser Ser 
    10625                 10630                 10635             


Ala Ile   Pro Thr Asn Ile Ser   Pro Ser Glu Leu Asp   Ala Leu Thr 
    10640                 10645                 10650             


Pro Leu   Val Thr Ile Ser Gly   Thr Asp Thr Ser Thr   Thr Phe Pro 
    10655                 10660                 10665             


Thr Leu   Thr Lys Ser Pro His   Glu Thr Glu Thr Arg   Thr Thr Trp 
    10670                 10675                 10680             


Leu Thr   His Pro Ala Glu Thr   Ser Ser Thr Ile Pro   Arg Thr Ile 
    10685                 10690                 10695             


Pro Asn   Phe Ser His His Glu   Ser Asp Ala Thr Pro   Ser Ile Ala 
    10700                 10705                 10710             


Thr Ser   Pro Gly Ala Glu Thr   Ser Ser Ala Ile Pro   Ile Met Thr 
    10715                 10720                 10725             


Val Ser   Pro Gly Ala Glu Asp   Leu Val Thr Ser Gln   Val Thr Ser 
    10730                 10735                 10740             


Ser Gly   Thr Asp Arg Asn Met   Thr Ile Pro Thr Leu   Thr Leu Ser 
    10745                 10750                 10755             


Pro Gly   Glu Pro Lys Thr Ile   Ala Ser Leu Val Thr   His Pro Glu 
    10760                 10765                 10770             


Ala Gln   Thr Ser Ser Ala Ile   Pro Thr Ser Thr Ile   Ser Pro Ala 
    10775                 10780                 10785             


Val Ser   Arg Leu Val Thr Ser   Met Val Thr Ser Leu   Ala Ala Lys 
    10790                 10795                 10800             


Thr Ser   Thr Thr Asn Arg Ala   Leu Thr Asn Ser Pro   Gly Glu Pro 
    10805                 10810                 10815             


Ala Thr   Thr Val Ser Leu Val   Thr His Pro Ala Gln   Thr Ser Pro 
    10820                 10825                 10830             


Thr Val   Pro Trp Thr Thr Ser   Ile Phe Phe His Ser   Lys Ser Asp 
    10835                 10840                 10845             


Thr Thr   Pro Ser Met Thr Thr   Ser His Gly Ala Glu   Ser Ser Ser 
    10850                 10855                 10860             


Ala Val   Pro Thr Pro Thr Val   Ser Thr Glu Val Pro   Gly Val Val 
    10865                 10870                 10875             


Thr Pro   Leu Val Thr Ser Ser   Arg Ala Val Ile Ser   Thr Thr Ile 
    10880                 10885                 10890             


Pro Ile   Leu Thr Leu Ser Pro   Gly Glu Pro Glu Thr   Thr Pro Ser 
    10895                 10900                 10905             


Met Ala   Thr Ser His Gly Glu   Glu Ala Ser Ser Ala   Ile Pro Thr 
    10910                 10915                 10920             


Pro Thr   Val Ser Pro Gly Val   Pro Gly Val Val Thr   Ser Leu Val 
    10925                 10930                 10935             


Thr Ser   Ser Arg Ala Val Thr   Ser Thr Thr Ile Pro   Ile Leu Thr 
    10940                 10945                 10950             


Phe Ser   Leu Gly Glu Pro Glu   Thr Thr Pro Ser Met   Ala Thr Ser 
    10955                 10960                 10965             


His Gly   Thr Glu Ala Gly Ser   Ala Val Pro Thr Val   Leu Pro Glu 
    10970                 10975                 10980             


Val Pro   Gly Met Val Thr Ser   Leu Val Ala Ser Ser   Arg Ala Val 
    10985                 10990                 10995             


Thr Ser   Thr Thr Leu Pro Thr   Leu Thr Leu Ser Pro   Gly Glu Pro 
    11000                 11005                 11010             


Glu Thr   Thr Pro Ser Met Ala   Thr Ser His Gly Ala   Glu Ala Ser 
    11015                 11020                 11025             


Ser Thr   Val Pro Thr Val Ser   Pro Glu Val Pro Gly   Val Val Thr 
    11030                 11035                 11040             


Ser Leu   Val Thr Ser Ser Ser   Gly Val Asn Ser Thr   Ser Ile Pro 
    11045                 11050                 11055             


Thr Leu   Ile Leu Ser Pro Gly   Glu Leu Glu Thr Thr   Pro Ser Met 
    11060                 11065                 11070             


Ala Thr   Ser His Gly Ala Glu   Ala Ser Ser Ala Val   Pro Thr Pro 
    11075                 11080                 11085             


Thr Val   Ser Pro Gly Val Ser   Gly Val Val Thr Pro   Leu Val Thr 
    11090                 11095                 11100             


Ser Ser   Arg Ala Val Thr Ser   Thr Thr Ile Pro Ile   Leu Thr Leu 
    11105                 11110                 11115             


Ser Ser   Ser Glu Pro Glu Thr   Thr Pro Ser Met Ala   Thr Ser His 
    11120                 11125                 11130             


Gly Val   Glu Ala Ser Ser Ala   Val Leu Thr Val Ser   Pro Glu Val 
    11135                 11140                 11145             


Pro Gly   Met Val Thr Ser Leu   Val Thr Ser Ser Arg   Ala Val Thr 
    11150                 11155                 11160             


Ser Thr   Thr Ile Pro Thr Leu   Thr Ile Ser Ser Asp   Glu Pro Glu 
    11165                 11170                 11175             


Thr Thr   Thr Ser Leu Val Thr   His Ser Glu Ala Lys   Met Ile Ser 
    11180                 11185                 11190             


Ala Ile   Pro Thr Leu Ala Val   Ser Pro Thr Val Gln   Gly Leu Val 
    11195                 11200                 11205             


Thr Ser   Leu Val Thr Ser Ser   Gly Ser Glu Thr Ser   Ala Phe Ser 
    11210                 11215                 11220             


Asn Leu   Thr Val Ala Ser Ser   Gln Pro Glu Thr Ile   Asp Ser Trp 
    11225                 11230                 11235             


Val Ala   His Pro Gly Thr Glu   Ala Ser Ser Val Val   Pro Thr Leu 
    11240                 11245                 11250             


Thr Val   Ser Thr Gly Glu Pro   Phe Thr Asn Ile Ser   Leu Val Thr 
    11255                 11260                 11265             


His Pro   Ala Glu Ser Ser Ser   Thr Leu Pro Arg Thr   Thr Ser Arg 
    11270                 11275                 11280             


Phe Ser   His Ser Glu Leu Asp   Thr Met Pro Ser Thr   Val Thr Ser 
    11285                 11290                 11295             


Pro Glu   Ala Glu Ser Ser Ser   Ala Ile Ser Thr Thr   Ile Ser Pro 
    11300                 11305                 11310             


Gly Ile   Pro Gly Val Leu Thr   Ser Leu Val Thr Ser   Ser Gly Arg 
    11315                 11320                 11325             


Asp Ile   Ser Ala Thr Phe Pro   Thr Val Pro Glu Ser   Pro His Glu 
    11330                 11335                 11340             


Ser Glu   Ala Thr Ala Ser Trp   Val Thr His Pro Ala   Val Thr Ser 
    11345                 11350                 11355             


Thr Thr   Val Pro Arg Thr Thr   Pro Asn Tyr Ser His   Ser Glu Pro 
    11360                 11365                 11370             


Asp Thr   Thr Pro Ser Ile Ala   Thr Ser Pro Gly Ala   Glu Ala Thr 
    11375                 11380                 11385             


Ser Asp   Phe Pro Thr Ile Thr   Val Ser Pro Asp Val   Pro Asp Met 
    11390                 11395                 11400             


Val Thr   Ser Gln Val Thr Ser   Ser Gly Thr Asp Thr   Ser Ile Thr 
    11405                 11410                 11415             


Ile Pro   Thr Leu Thr Leu Ser   Ser Gly Glu Pro Glu   Thr Thr Thr 
    11420                 11425                 11430             


Ser Phe   Ile Thr Tyr Ser Glu   Thr His Thr Ser Ser   Ala Ile Pro 
    11435                 11440                 11445             


Thr Leu   Pro Val Ser Pro Gly   Ala Ser Lys Met Leu   Thr Ser Leu 
    11450                 11455                 11460             


Val Ile   Ser Ser Gly Thr Asp   Ser Thr Thr Thr Phe   Pro Thr Leu 
    11465                 11470                 11475             


Thr Glu   Thr Pro Tyr Glu Pro   Glu Thr Thr Ala Ile   Gln Leu Ile 
    11480                 11485                 11490             


His Pro   Ala Glu Thr Asn Thr   Met Val Pro Arg Thr   Thr Pro Lys 
    11495                 11500                 11505             


Phe Ser   His Ser Lys Ser Asp   Thr Thr Leu Pro Val   Ala Ile Thr 
    11510                 11515                 11520             


Ser Pro   Gly Pro Glu Ala Ser   Ser Ala Val Ser Thr   Thr Thr Ile 
    11525                 11530                 11535             


Ser Pro   Asp Met Ser Asp Leu   Val Thr Ser Leu Val   Pro Ser Ser 
    11540                 11545                 11550             


Gly Thr   Asp Thr Ser Thr Thr   Phe Pro Thr Leu Ser   Glu Thr Pro 
    11555                 11560                 11565             


Tyr Glu   Pro Glu Thr Thr Ala   Thr Trp Leu Thr His   Pro Ala Glu 
    11570                 11575                 11580             


Thr Ser   Thr Thr Val Ser Gly   Thr Ile Pro Asn Phe   Ser His Arg 
    11585                 11590                 11595             


Gly Ser   Asp Thr Ala Pro Ser   Met Val Thr Ser Pro   Gly Val Asp 
    11600                 11605                 11610             


Thr Arg   Ser Gly Val Pro Thr   Thr Thr Ile Pro Pro   Ser Ile Pro 
    11615                 11620                 11625             


Gly Val   Val Thr Ser Gln Val   Thr Ser Ser Ala Thr   Asp Thr Ser 
    11630                 11635                 11640             


Thr Ala   Ile Pro Thr Leu Thr   Pro Ser Pro Gly Glu   Pro Glu Thr 
    11645                 11650                 11655             


Thr Ala   Ser Ser Ala Thr His   Pro Gly Thr Gln Thr   Gly Phe Thr 
    11660                 11665                 11670             


Val Pro   Ile Arg Thr Val Pro   Ser Ser Glu Pro Asp   Thr Met Ala 
    11675                 11680                 11685             


Ser Trp   Val Thr His Pro Pro   Gln Thr Ser Thr Pro   Val Ser Arg 
    11690                 11695                 11700             


Thr Thr   Ser Ser Phe Ser His   Ser Ser Pro Asp Ala   Thr Pro Val 
    11705                 11710                 11715             


Met Ala   Thr Ser Pro Arg Thr   Glu Ala Ser Ser Ala   Val Leu Thr 
    11720                 11725                 11730             


Thr Ile   Ser Pro Gly Ala Pro   Glu Met Val Thr Ser   Gln Ile Thr 
    11735                 11740                 11745             


Ser Ser   Gly Ala Ala Thr Ser   Thr Thr Val Pro Thr   Leu Thr His 
    11750                 11755                 11760             


Ser Pro   Gly Met Pro Glu Thr   Thr Ala Leu Leu Ser   Thr His Pro 
    11765                 11770                 11775             


Arg Thr   Glu Thr Ser Lys Thr   Phe Pro Ala Ser Thr   Val Phe Pro 
    11780                 11785                 11790             


Gln Val   Ser Glu Thr Thr Ala   Ser Leu Thr Ile Arg   Pro Gly Ala 
    11795                 11800                 11805             


Glu Thr   Ser Thr Ala Leu Pro   Thr Gln Thr Thr Ser   Ser Leu Phe 
    11810                 11815                 11820             


Thr Leu   Leu Val Thr Gly Thr   Ser Arg Val Asp Leu   Ser Pro Thr 
    11825                 11830                 11835             


Ala Ser   Pro Gly Val Ser Ala   Lys Thr Ala Pro Leu   Ser Thr His 
    11840                 11845                 11850             


Pro Gly   Thr Glu Thr Ser Thr   Met Ile Pro Thr Ser   Thr Leu Ser 
    11855                 11860                 11865             


Leu Gly   Leu Leu Glu Thr Thr   Gly Leu Leu Ala Thr   Ser Ser Ser 
    11870                 11875                 11880             


Ala Glu   Thr Ser Thr Ser Thr   Leu Thr Leu Thr Val   Ser Pro Ala 
    11885                 11890                 11895             


Val Ser   Gly Leu Ser Ser Ala   Ser Ile Thr Thr Asp   Lys Pro Gln 
    11900                 11905                 11910             


Thr Val   Thr Ser Trp Asn Thr   Glu Thr Ser Pro Ser   Val Thr Ser 
    11915                 11920                 11925             


Val Gly   Pro Pro Glu Phe Ser   Arg Thr Val Thr Gly   Thr Thr Met 
    11930                 11935                 11940             


Thr Leu   Ile Pro Ser Glu Met   Pro Thr Pro Pro Lys   Thr Ser His 
    11945                 11950                 11955             


Gly Glu   Gly Val Ser Pro Thr   Thr Ile Leu Arg Thr   Thr Met Val 
    11960                 11965                 11970             


Glu Ala   Thr Asn Leu Ala Thr   Thr Gly Ser Ser Pro   Thr Val Ala 
    11975                 11980                 11985             


Lys Thr   Thr Thr Thr Phe Asn   Thr Leu Ala Gly Ser   Leu Phe Thr 
    11990                 11995                 12000             


Pro Leu   Thr Thr Pro Gly Met   Ser Thr Leu Ala Ser   Glu Ser Val 
    12005                 12010                 12015             


Thr Ser   Arg Thr Ser Tyr Asn   His Arg Ser Trp Ile   Ser Thr Thr 
    12020                 12025                 12030             


Ser Ser   Tyr Asn Arg Arg Tyr   Trp Thr Pro Ala Thr   Ser Thr Pro 
    12035                 12040                 12045             


Val Thr   Ser Thr Phe Ser Pro   Gly Ile Ser Thr Ser   Ser Ile Pro 
    12050                 12055                 12060             


Ser Ser   Thr Ala Ala Thr Val   Pro Phe Met Val Pro   Phe Thr Leu 
    12065                 12070                 12075             


Asn Phe   Thr Ile Thr Asn Leu   Gln Tyr Glu Glu Asp   Met Arg His 
    12080                 12085                 12090             


Pro Gly   Ser Arg Lys Phe Asn   Ala Thr Glu Arg Glu   Leu Gln Gly 
    12095                 12100                 12105             


Leu Leu   Lys Pro Leu Phe Arg   Asn Ser Ser Leu Glu   Tyr Leu Tyr 
    12110                 12115                 12120             


Ser Gly   Cys Arg Leu Ala Ser   Leu Arg Pro Glu Lys   Asp Ser Ser 
    12125                 12130                 12135             


Ala Thr   Ala Val Asp Ala Ile   Cys Thr His Arg Pro   Asp Pro Glu 
    12140                 12145                 12150             


Asp Leu   Gly Leu Asp Arg Glu   Arg Leu Tyr Trp Glu   Leu Ser Asn 
    12155                 12160                 12165             


Leu Thr   Asn Gly Ile Gln Glu   Leu Gly Pro Tyr Thr   Leu Asp Arg 
    12170                 12175                 12180             


Asn Ser   Leu Tyr Val Asn Gly   Phe Thr His Arg Ser   Ser Met Pro 
    12185                 12190                 12195             


Thr Thr   Ser Thr Pro Gly Thr   Ser Thr Val Asp Val   Gly Thr Ser 
    12200                 12205                 12210             


Gly Thr   Pro Ser Ser Ser Pro   Ser Pro Thr Thr Ala   Gly Pro Leu 
    12215                 12220                 12225             


Leu Met   Pro Phe Thr Leu Asn   Phe Thr Ile Thr Asn   Leu Gln Tyr 
    12230                 12235                 12240             


Glu Glu   Asp Met Arg Arg Thr   Gly Ser Arg Lys Phe   Asn Thr Met 
    12245                 12250                 12255             


Glu Ser   Val Leu Gln Gly Leu   Leu Lys Pro Leu Phe   Lys Asn Thr 
    12260                 12265                 12270             


Ser Val   Gly Pro Leu Tyr Ser   Gly Cys Arg Leu Thr   Leu Leu Arg 
    12275                 12280                 12285             


Pro Glu   Lys Asp Gly Ala Ala   Thr Gly Val Asp Ala   Ile Cys Thr 
    12290                 12295                 12300             


His Arg   Leu Asp Pro Lys Ser   Pro Gly Leu Asn Arg   Glu Gln Leu 
    12305                 12310                 12315             


Tyr Trp   Glu Leu Ser Lys Leu   Thr Asn Asp Ile Glu   Glu Leu Gly 
    12320                 12325                 12330             


Pro Tyr   Thr Leu Asp Arg Asn   Ser Leu Tyr Val Asn   Gly Phe Thr 
    12335                 12340                 12345             


His Gln   Ser Ser Val Ser Thr   Thr Ser Thr Pro Gly   Thr Ser Thr 
    12350                 12355                 12360             


Val Asp   Leu Arg Thr Ser Gly   Thr Pro Ser Ser Leu   Ser Ser Pro 
    12365                 12370                 12375             


Thr Ile   Met Ala Ala Gly Pro   Leu Leu Val Pro Phe   Thr Leu Asn 
    12380                 12385                 12390             


Phe Thr   Ile Thr Asn Leu Gln   Tyr Gly Glu Asp Met   Gly His Pro 
    12395                 12400                 12405             


Gly Ser   Arg Lys Phe Asn Thr   Thr Glu Arg Val Leu   Gln Gly Leu 
    12410                 12415                 12420             


Leu Gly   Pro Ile Phe Lys Asn   Thr Ser Val Gly Pro   Leu Tyr Ser 
    12425                 12430                 12435             


Gly Cys   Arg Leu Thr Ser Leu   Arg Ser Glu Lys Asp   Gly Ala Ala 
    12440                 12445                 12450             


Thr Gly   Val Asp Ala Ile Cys   Ile His His Leu Asp   Pro Lys Ser 
    12455                 12460                 12465             


Pro Gly   Leu Asn Arg Glu Arg   Leu Tyr Trp Glu Leu   Ser Gln Leu 
    12470                 12475                 12480             


Thr Asn   Gly Ile Lys Glu Leu   Gly Pro Tyr Thr Leu   Asp Arg Asn 
    12485                 12490                 12495             


Ser Leu   Tyr Val Asn Gly Phe   Thr His Arg Thr Ser   Val Pro Thr 
    12500                 12505                 12510             


Ser Ser   Thr Pro Gly Thr Ser   Thr Val Asp Leu Gly   Thr Ser Gly 
    12515                 12520                 12525             


Thr Pro   Phe Ser Leu Pro Ser   Pro Ala Thr Ala Gly   Pro Leu Leu 
    12530                 12535                 12540             


Val Leu   Phe Thr Leu Asn Phe   Thr Ile Thr Asn Leu   Lys Tyr Glu 
    12545                 12550                 12555             


Glu Asp   Met His Arg Pro Gly   Ser Arg Lys Phe Asn   Thr Thr Glu 
    12560                 12565                 12570             


Arg Val   Leu Gln Thr Leu Leu   Gly Pro Met Phe Lys   Asn Thr Ser 
    12575                 12580                 12585             


Val Gly   Leu Leu Tyr Ser Gly   Cys Arg Leu Thr Leu   Leu Arg Ser 
    12590                 12595                 12600             


Glu Lys   Asp Gly Ala Ala Thr   Gly Val Asp Ala Ile   Cys Thr His 
    12605                 12610                 12615             


Arg Leu   Asp Pro Lys Ser Pro   Gly Val Asp Arg Glu   Gln Leu Tyr 
    12620                 12625                 12630             


Trp Glu   Leu Ser Gln Leu Thr   Asn Gly Ile Lys Glu   Leu Gly Pro 
    12635                 12640                 12645             


Tyr Thr   Leu Asp Arg Asn Ser   Leu Tyr Val Asn Gly   Phe Thr His 
    12650                 12655                 12660             


Trp Ile   Pro Val Pro Thr Ser   Ser Thr Pro Gly Thr   Ser Thr Val 
    12665                 12670                 12675             


Asp Leu   Gly Ser Gly Thr Pro   Ser Ser Leu Pro Ser   Pro Thr Thr 
    12680                 12685                 12690             


Ala Gly   Pro Leu Leu Val Pro   Phe Thr Leu Asn Phe   Thr Ile Thr 
    12695                 12700                 12705             


Asn Leu   Lys Tyr Glu Glu Asp   Met His Cys Pro Gly   Ser Arg Lys 
    12710                 12715                 12720             


Phe Asn   Thr Thr Glu Arg Val   Leu Gln Ser Leu Leu   Gly Pro Met 
    12725                 12730                 12735             


Phe Lys   Asn Thr Ser Val Gly   Pro Leu Tyr Ser Gly   Cys Arg Leu 
    12740                 12745                 12750             


Thr Leu   Leu Arg Ser Glu Lys   Asp Gly Ala Ala Thr   Gly Val Asp 
    12755                 12760                 12765             


Ala Ile   Cys Thr His Arg Leu   Asp Pro Lys Ser Pro   Gly Val Asp 
    12770                 12775                 12780             


Arg Glu   Gln Leu Tyr Trp Glu   Leu Ser Gln Leu Thr   Asn Gly Ile 
    12785                 12790                 12795             


Lys Glu   Leu Gly Pro Tyr Thr   Leu Asp Arg Asn Ser   Leu Tyr Val 
    12800                 12805                 12810             


Asn Gly   Phe Thr His Gln Thr   Ser Ala Pro Asn Thr   Ser Thr Pro 
    12815                 12820                 12825             


Gly Thr   Ser Thr Val Asp Leu   Gly Thr Ser Gly Thr   Pro Ser Ser 
    12830                 12835                 12840             


Leu Pro   Ser Pro Thr Ser Ala   Gly Pro Leu Leu Val   Pro Phe Thr 
    12845                 12850                 12855             


Leu Asn   Phe Thr Ile Thr Asn   Leu Gln Tyr Glu Glu   Asp Met His 
    12860                 12865                 12870             


His Pro   Gly Ser Arg Lys Phe   Asn Thr Thr Glu Arg   Val Leu Gln 
    12875                 12880                 12885             


Gly Leu   Leu Gly Pro Met Phe   Lys Asn Thr Ser Val   Gly Leu Leu 
    12890                 12895                 12900             


Tyr Ser   Gly Cys Arg Leu Thr   Leu Leu Arg Pro Glu   Lys Asn Gly 
    12905                 12910                 12915             


Ala Ala   Thr Gly Met Asp Ala   Ile Cys Ser His Arg   Leu Asp Pro 
    12920                 12925                 12930             


Lys Ser   Pro Gly Leu Asn Arg   Glu Gln Leu Tyr Trp   Glu Leu Ser 
    12935                 12940                 12945             


Gln Leu   Thr His Gly Ile Lys   Glu Leu Gly Pro Tyr   Thr Leu Asp 
    12950                 12955                 12960             


Arg Asn   Ser Leu Tyr Val Asn   Gly Phe Thr His Arg   Ser Ser Val 
    12965                 12970                 12975             


Ala Pro   Thr Ser Thr Pro Gly   Thr Ser Thr Val Asp   Leu Gly Thr 
    12980                 12985                 12990             


Ser Gly   Thr Pro Ser Ser Leu   Pro Ser Pro Thr Thr   Ala Val Pro 
    12995                 13000                 13005             


Leu Leu   Val Pro Phe Thr Leu   Asn Phe Thr Ile Thr   Asn Leu Gln 
    13010                 13015                 13020             


Tyr Gly   Glu Asp Met Arg His   Pro Gly Ser Arg Lys   Phe Asn Thr 
    13025                 13030                 13035             


Thr Glu   Arg Val Leu Gln Gly   Leu Leu Gly Pro Leu   Phe Lys Asn 
    13040                 13045                 13050             


Ser Ser   Val Gly Pro Leu Tyr   Ser Gly Cys Arg Leu   Ile Ser Leu 
    13055                 13060                 13065             


Arg Ser   Glu Lys Asp Gly Ala   Ala Thr Gly Val Asp   Ala Ile Cys 
    13070                 13075                 13080             


Thr His   His Leu Asn Pro Gln   Ser Pro Gly Leu Asp   Arg Glu Gln 
    13085                 13090                 13095             


Leu Tyr   Trp Gln Leu Ser Gln   Met Thr Asn Gly Ile   Lys Glu Leu 
    13100                 13105                 13110             


Gly Pro   Tyr Thr Leu Asp Arg   Asn Ser Leu Tyr Val   Asn Gly Phe 
    13115                 13120                 13125             


Thr His   Arg Ser Ser Gly Leu   Thr Thr Ser Thr Pro   Trp Thr Ser 
    13130                 13135                 13140             


Thr Val   Asp Leu Gly Thr Ser   Gly Thr Pro Ser Pro   Val Pro Ser 
    13145                 13150                 13155             


Pro Thr   Thr Thr Gly Pro Leu   Leu Val Pro Phe Thr   Leu Asn Phe 
    13160                 13165                 13170             


Thr Ile   Thr Asn Leu Gln Tyr   Glu Glu Asn Met Gly   His Pro Gly 
    13175                 13180                 13185             


Ser Arg   Lys Phe Asn Ile Thr   Glu Ser Val Leu Gln   Gly Leu Leu 
    13190                 13195                 13200             


Lys Pro   Leu Phe Lys Ser Thr   Ser Val Gly Pro Leu   Tyr Ser Gly 
    13205                 13210                 13215             


Cys Arg   Leu Thr Leu Leu Arg   Pro Glu Lys Asp Gly   Val Ala Thr 
    13220                 13225                 13230             


Arg Val   Asp Ala Ile Cys Thr   His Arg Pro Asp Pro   Lys Ile Pro 
    13235                 13240                 13245             


Gly Leu   Asp Arg Gln Gln Leu   Tyr Trp Glu Leu Ser   Gln Leu Thr 
    13250                 13255                 13260             


His Ser   Ile Thr Glu Leu Gly   Pro Tyr Thr Leu Asp   Arg Asp Ser 
    13265                 13270                 13275             


Leu Tyr   Val Asn Gly Phe Thr   Gln Arg Ser Ser Val   Pro Thr Thr 
    13280                 13285                 13290             


Ser Thr   Pro Gly Thr Phe Thr   Val Gln Pro Glu Thr   Ser Glu Thr 
    13295                 13300                 13305             


Pro Ser   Ser Leu Pro Gly Pro   Thr Ala Thr Gly Pro   Val Leu Leu 
    13310                 13315                 13320             


Pro Phe   Thr Leu Asn Phe Thr   Ile Thr Asn Leu Gln   Tyr Glu Glu 
    13325                 13330                 13335             


Asp Met   Arg Arg Pro Gly Ser   Arg Lys Phe Asn Thr   Thr Glu Arg 
    13340                 13345                 13350             


Val Leu   Gln Gly Leu Leu Met   Pro Leu Phe Lys Asn   Thr Ser Val 
    13355                 13360                 13365             


Ser Ser   Leu Tyr Ser Gly Cys   Arg Leu Thr Leu Leu   Arg Pro Glu 
    13370                 13375                 13380             


Lys Asp   Gly Ala Ala Thr Arg   Val Asp Ala Val Cys   Thr His Arg 
    13385                 13390                 13395             


Pro Asp   Pro Lys Ser Pro Gly   Leu Asp Arg Glu Arg   Leu Tyr Trp 
    13400                 13405                 13410             


Lys Leu   Ser Gln Leu Thr His   Gly Ile Thr Glu Leu   Gly Pro Tyr 
    13415                 13420                 13425             


Thr Leu   Asp Arg His Ser Leu   Tyr Val Asn Gly Phe   Thr His Gln 
    13430                 13435                 13440             


Ser Ser   Met Thr Thr Thr Arg   Thr Pro Asp Thr Ser   Thr Met His 
    13445                 13450                 13455             


Leu Ala   Thr Ser Arg Thr Pro   Ala Ser Leu Ser Gly   Pro Met Thr 
    13460                 13465                 13470             


Ala Ser   Pro Leu Leu Val Leu   Phe Thr Ile Asn Phe   Thr Ile Thr 
    13475                 13480                 13485             


Asn Leu   Arg Tyr Glu Glu Asn   Met His His Pro Gly   Ser Arg Lys 
    13490                 13495                 13500             


Phe Asn   Thr Thr Glu Arg Val   Leu Gln Gly Leu Leu   Arg Pro Val 
    13505                 13510                 13515             


Phe Lys   Asn Thr Ser Val Gly   Pro Leu Tyr Ser Gly   Cys Arg Leu 
    13520                 13525                 13530             


Thr Leu   Leu Arg Pro Lys Lys   Asp Gly Ala Ala Thr   Lys Val Asp 
    13535                 13540                 13545             


Ala Ile   Cys Thr Tyr Arg Pro   Asp Pro Lys Ser Pro   Gly Leu Asp 
    13550                 13555                 13560             


Arg Glu   Gln Leu Tyr Trp Glu   Leu Ser Gln Leu Thr   His Ser Ile 
    13565                 13570                 13575             


Thr Glu   Leu Gly Pro Tyr Thr   Leu Asp Arg Asp Ser   Leu Tyr Val 
    13580                 13585                 13590             


Asn Gly   Phe Thr Gln Arg Ser   Ser Val Pro Thr Thr   Ser Ile Pro 
    13595                 13600                 13605             


Gly Thr   Pro Thr Val Asp Leu   Gly Thr Ser Gly Thr   Pro Val Ser 
    13610                 13615                 13620             


Lys Pro   Gly Pro Ser Ala Ala   Ser Pro Leu Leu Val   Leu Phe Thr 
    13625                 13630                 13635             


Leu Asn   Phe Thr Ile Thr Asn   Leu Arg Tyr Glu Glu   Asn Met Gln 
    13640                 13645                 13650             


His Pro   Gly Ser Arg Lys Phe   Asn Thr Thr Glu Arg   Val Leu Gln 
    13655                 13660                 13665             


Gly Leu   Leu Arg Ser Leu Phe   Lys Ser Thr Ser Val   Gly Pro Leu 
    13670                 13675                 13680             


Tyr Ser   Gly Cys Arg Leu Thr   Leu Leu Arg Pro Glu   Lys Asp Gly 
    13685                 13690                 13695             


Thr Ala   Thr Gly Val Asp Ala   Ile Cys Thr His His   Pro Asp Pro 
    13700                 13705                 13710             


Lys Ser   Pro Arg Leu Asp Arg   Glu Gln Leu Tyr Trp   Glu Leu Ser 
    13715                 13720                 13725             


Gln Leu   Thr His Asn Ile Thr   Glu Leu Gly Pro Tyr   Ala Leu Asp 
    13730                 13735                 13740             


Asn Asp   Ser Leu Phe Val Asn   Gly Phe Thr His Arg   Ser Ser Val 
    13745                 13750                 13755             


Ser Thr   Thr Ser Thr Pro Gly   Thr Pro Thr Val Tyr   Leu Gly Ala 
    13760                 13765                 13770             


Ser Lys   Thr Pro Ala Ser Ile   Phe Gly Pro Ser Ala   Ala Ser His 
    13775                 13780                 13785             


Leu Leu   Ile Leu Phe Thr Leu   Asn Phe Thr Ile Thr   Asn Leu Arg 
    13790                 13795                 13800             


Tyr Glu   Glu Asn Met Trp Pro   Gly Ser Arg Lys Phe   Asn Thr Thr 
    13805                 13810                 13815             


Glu Arg   Val Leu Gln Gly Leu   Leu Arg Pro Leu Phe   Lys Asn Thr 
    13820                 13825                 13830             


Ser Val   Gly Pro Leu Tyr Ser   Gly Cys Arg Leu Thr   Leu Leu Arg 
    13835                 13840                 13845             


Pro Glu   Lys Asp Gly Glu Ala   Thr Gly Val Asp Ala   Ile Cys Thr 
    13850                 13855                 13860             


His Arg   Pro Asp Pro Thr Gly   Pro Gly Leu Asp Arg   Glu Gln Leu 
    13865                 13870                 13875             


Tyr Leu   Glu Leu Ser Gln Leu   Thr His Ser Ile Thr   Glu Leu Gly 
    13880                 13885                 13890             


Pro Tyr   Thr Leu Asp Arg Asp   Ser Leu Tyr Val Asn   Gly Phe Thr 
    13895                 13900                 13905             


His Arg   Ser Ser Val Pro Thr   Thr Ser Thr Gly Val   Val Ser Glu 
    13910                 13915                 13920             


Glu Pro   Phe Thr Leu Asn Phe   Thr Ile Asn Asn Leu   Arg Tyr Met 
    13925                 13930                 13935             


Ala Asp   Met Gly Gln Pro Gly   Ser Leu Lys Phe Asn   Ile Thr Asp 
    13940                 13945                 13950             


Asn Val   Met Gln His Leu Leu   Ser Pro Leu Phe Gln   Arg Ser Ser 
    13955                 13960                 13965             


Leu Gly   Ala Arg Tyr Thr Gly   Cys Arg Val Ile Ala   Leu Arg Ser 
    13970                 13975                 13980             


Val Lys   Asn Gly Ala Glu Thr   Arg Val Asp Leu Leu   Cys Thr Tyr 
    13985                 13990                 13995             


Leu Gln   Pro Leu Ser Gly Pro   Gly Leu Pro Ile Lys   Gln Val Phe 
    14000                 14005                 14010             


His Glu   Leu Ser Gln Gln Thr   His Gly Ile Thr Arg   Leu Gly Pro 
    14015                 14020                 14025             


Tyr Ser   Leu Asp Lys Asp Ser   Leu Tyr Leu Asn Gly   Tyr Asn Glu 
    14030                 14035                 14040             


Pro Gly   Pro Asp Glu Pro Pro   Thr Thr Pro Lys Pro   Ala Thr Thr 
    14045                 14050                 14055             


Phe Leu   Pro Pro Leu Ser Glu   Ala Thr Thr Ala Met   Gly Tyr His 
    14060                 14065                 14070             


Leu Lys   Thr Leu Thr Leu Asn   Phe Thr Ile Ser Asn   Leu Gln Tyr 
    14075                 14080                 14085             


Ser Pro   Asp Met Gly Lys Gly   Ser Ala Thr Phe Asn   Ser Thr Glu 
    14090                 14095                 14100             


Gly Val   Leu Gln His Leu Leu   Arg Pro Leu Phe Gln   Lys Ser Ser 
    14105                 14110                 14115             


Met Gly   Pro Phe Tyr Leu Gly   Cys Gln Leu Ile Ser   Leu Arg Pro 
    14120                 14125                 14130             


Glu Lys   Asp Gly Ala Ala Thr   Gly Val Asp Thr Thr   Cys Thr Tyr 
    14135                 14140                 14145             


His Pro   Asp Pro Val Gly Pro   Gly Leu Asp Ile Gln   Gln Leu Tyr 
    14150                 14155                 14160             


Trp Glu   Leu Ser Gln Leu Thr   His Gly Val Thr Gln   Leu Gly Phe 
    14165                 14170                 14175             


Tyr Val   Leu Asp Arg Asp Ser   Leu Phe Ile Asn Gly   Tyr Ala Pro 
    14180                 14185                 14190             


Gln Asn   Leu Ser Ile Arg Gly   Glu Tyr Gln Ile Asn   Phe His Ile 
    14195                 14200                 14205             


Val Asn   Trp Asn Leu Ser Asn   Pro Asp Pro Thr Ser   Ser Glu Tyr 
    14210                 14215                 14220             


Ile Thr   Leu Leu Arg Asp Ile   Gln Asp Lys Val Thr   Thr Leu Tyr 
    14225                 14230                 14235             


Lys Gly   Ser Gln Leu His Asp   Thr Phe Arg Phe Cys   Leu Val Thr 
    14240                 14245                 14250             


Asn Leu   Thr Met Asp Ser Val   Leu Val Thr Val Lys   Ala Leu Phe 
    14255                 14260                 14265             


Ser Ser   Asn Leu Asp Pro Ser   Leu Val Glu Gln Val   Phe Leu Asp 
    14270                 14275                 14280             


Lys Thr   Leu Asn Ala Ser Phe   His Trp Leu Gly Ser   Thr Tyr Gln 
    14285                 14290                 14295             


Leu Val   Asp Ile His Val Thr   Glu Met Glu Ser Ser   Val Tyr Gln 
    14300                 14305                 14310             


Pro Thr   Ser Ser Ser Ser Thr   Gln His Phe Tyr Leu   Asn Phe Thr 
    14315                 14320                 14325             


Ile Thr   Asn Leu Pro Tyr Ser   Gln Asp Lys Ala Gln   Pro Gly Thr 
    14330                 14335                 14340             


Thr Asn   Tyr Gln Arg Asn Lys   Arg Asn Ile Glu Asp   Ala Leu Asn 
    14345                 14350                 14355             


Gln Leu   Phe Arg Asn Ser Ser   Ile Lys Ser Tyr Phe   Ser Asp Cys 
    14360                 14365                 14370             


Gln Val   Ser Thr Phe Arg Ser   Val Pro Asn Arg His   His Thr Gly 
    14375                 14380                 14385             


Val Asp   Ser Leu Cys Asn Phe   Ser Pro Leu Ala Arg   Arg Val Asp 
    14390                 14395                 14400             


Arg Val   Ala Ile Tyr Glu Glu   Phe Leu Arg Met Thr   Arg Asn Gly 
    14405                 14410                 14415             


Thr Gln   Leu Gln Asn Phe Thr   Leu Asp Arg Ser Ser   Val Leu Val 
    14420                 14425                 14430             


Asp Gly   Tyr Ser Pro Asn Arg   Asn Glu Pro Leu Thr   Gly Asn Ser 
    14435                 14440                 14445             


Asp Leu   Pro Phe Trp Ala Val   Ile Leu Ile Gly Leu   Ala Gly Leu 
    14450                 14455                 14460             


Leu Gly   Val Ile Thr Cys Leu   Ile Cys Gly Val Leu   Val Thr Thr 
    14465                 14470                 14475             


Arg Arg   Arg Lys Lys Glu Gly   Glu Tyr Asn Val Gln   Gln Gln Cys 
    14480                 14485                 14490             


Pro Gly   Tyr Tyr Gln Ser His   Leu Asp Leu Glu Asp   Leu Gln 
    14495                 14500                 14505         


<210>  5068
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  5068

Met Thr Val Gly Ala Arg Leu Arg Ser Lys Ala Glu Ser Ser Leu Leu 
1               5                   10                  15      


Arg Arg Gly Pro Arg Gly Arg Gly Arg Thr Glu Gly Asp Glu Glu Ala 
            20                  25                  30          


Ala Ala Ile Leu Glu His Leu Glu Tyr Ala Asp Glu Ala Glu Ala Ala 
        35                  40                  45              


Ala Glu Ser Gly Thr Ser Ala Ala Asp Glu Arg Gly Pro Gly Thr Arg 
    50                  55                  60                  


Gly Ala Arg Arg Val His Phe Ala Leu Leu Pro Glu Arg Tyr Glu Pro 
65                  70                  75                  80  


Leu Glu Glu Pro Ala Pro Ser Glu Gln Pro Arg Lys Arg Tyr Arg Arg 
                85                  90                  95      


Lys Leu Lys Lys Tyr Gly Lys Asn Val Gly Lys Val Ile Ile Lys Gly 
            100                 105                 110         


Cys Arg Tyr Val Val Ile Gly Leu Gln Gly Phe Ala Ala Ala Tyr Ser 
        115                 120                 125             


Ala Pro Phe Ala Val Ala Thr Ser Val Val Ser Phe Val Arg 
    130                 135                 140         


<210>  5069
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  5069

Met Val Pro Ala Ala Gly Arg Arg Pro Pro Arg Val Met Arg Leu Leu 
1               5                   10                  15      


Gly Trp Trp Gln Val Leu Leu Trp Val Leu Gly Leu Pro Val Arg Gly 
            20                  25                  30          


Val Glu Val Ala Glu Glu Ser Gly Arg Leu Trp Ser Glu Glu Gln Pro 
        35                  40                  45              


Ala His Pro Leu Gln Val Gly Ala Val Tyr Leu Gly Glu Glu Glu Leu 
    50                  55                  60                  


Leu His Asp Pro Met Gly Gln Asp Arg Ala Ala Glu Glu Ala Asn Ala 
65                  70                  75                  80  


Val Leu Gly Leu Asp Thr Gln Gly Asp His Met Val Met Leu Ser Val 
                85                  90                  95      


Ile Pro Gly Glu Ala Glu Asp Lys Val Ser Ser Glu Pro Ser Gly Val 
            100                 105                 110         


Thr Cys Gly Ala Gly Gly Ala Glu Asp Ser Arg Cys Asn Val Arg Glu 
        115                 120                 125             


Ser Leu Phe Ser Leu Asp Gly Ala Gly Ala His Phe Pro Asp Arg Glu 
    130                 135                 140                 


Glu Glu Tyr Tyr Thr Glu Pro Glu Val Ala Glu Ser Asp Ala Ala Pro 
145                 150                 155                 160 


Thr Glu Asp Ser Asn Asn Thr Glu Ser Leu Lys Ser Pro Lys Val Asn 
                165                 170                 175     


Cys Glu Glu Arg Asn Ile Thr Gly Leu Glu Asn Phe Thr Leu Lys Ile 
            180                 185                 190         


Leu Asn Met Ser Gln Asp Leu Met Asp Phe Leu Asn Pro Asn Gly Ser 
        195                 200                 205             


Asp Cys Thr Leu Val Leu Phe Tyr Thr Pro Trp Cys Arg Phe Ser Ala 
    210                 215                 220                 


Ser Leu Ala Pro His Phe Asn Ser Leu Pro Arg Ala Phe Pro Ala Leu 
225                 230                 235                 240 


His Phe Leu Ala Leu Asp Ala Ser Gln His Ser Ser Leu Ser Thr Arg 
                245                 250                 255     


Phe Gly Thr Val Ala Val Pro Asn Ile Leu Leu Phe Gln Gly Ala Lys 
            260                 265                 270         


Pro Met Ala Arg Phe Asn His Thr Asp Arg Thr Leu Glu Thr Leu Lys 
        275                 280                 285             


Ile Phe Ile Phe Asn Gln Thr Gly Ile Glu Ala Lys Lys Asn Val Val 
    290                 295                 300                 


Val Thr Gln Ala Asp Gln Ile Gly Pro Leu Pro Ser Thr Leu Ile Lys 
305                 310                 315                 320 


Ser Val Asp Trp Leu Leu Val Phe Ser Leu Phe Phe Leu Ile Ser Phe 
                325                 330                 335     


Ile Met Tyr Ala Thr Ile Arg Thr Glu Ser Ile Arg Trp Leu Ile Pro 
            340                 345                 350         


Gly Gln Glu Gln Glu His Val Glu 
        355                 360 


<210>  5070
<211>  999
<212>  PRT
<213>  Homo sapiens

<400>  5070

Met Glu Pro Arg Ala Ala Ala Ala Gly Glu Pro Glu Pro Pro Ala Ala 
1               5                   10                  15      


Ser Ser Ser Phe Gln Ala Arg Leu Trp Lys Asn Leu Gln Leu Gly Val 
            20                  25                  30          


Gly Arg Ser Lys Gly Gly Gly Gly Gly Arg Ala Gly Gly Pro Glu Arg 
        35                  40                  45              


Arg Thr Ala Asp Thr Pro Ser Pro Ser Pro Pro Pro Pro Val Gly Thr 
    50                  55                  60                  


Gly Asn Ala Pro Ala Arg Gly Ser Gly Ala Gly Ser Arg Trp Ser Gly 
65                  70                  75                  80  


Phe Lys Lys Arg Lys Gln Val Leu Asp Arg Val Phe Ser Ser Ser Gln 
                85                  90                  95      


Pro Asn Leu Cys Cys Ser Ser Pro Glu Pro Leu Glu Pro Gly Gly Ala 
            100                 105                 110         


Gly Arg Ala Glu Gln Gly Ser Thr Leu Arg Arg Arg Ile Arg Glu His 
        115                 120                 125             


Leu Leu Pro Ala Val Lys Gly Pro Ala Ala Ala Ser Gly Ala Ala Gly 
    130                 135                 140                 


Gly Thr Pro Pro Gly Gly Arg Ser Pro Asp Ser Ala Pro Ser Ser Ser 
145                 150                 155                 160 


Ser Ala Ser Ser Ser Leu Ser Ser Ser Pro Gln Pro Pro Pro Arg Gly 
                165                 170                 175     


Asp Arg Ala Arg Asp Glu Gly Ala Arg Arg Gln Gly Pro Gly Ala His 
            180                 185                 190         


Leu Cys His Gln Lys Ser Ser Ser Leu Pro Gly Thr Ala Cys Leu Glu 
        195                 200                 205             


Gln Leu Leu Glu Pro Pro Pro Pro Pro Ala Glu Pro Ala Arg Ser Pro 
    210                 215                 220                 


Ala Glu Ser Arg Ala Pro Glu Thr Gly Glu Glu His Gly Ser Ser Gln 
225                 230                 235                 240 


Lys Ile Ile Asn Thr Ala Gly Thr Ser Asn Ala Glu Val Pro Leu Ala 
                245                 250                 255     


Asp Pro Gly Met Tyr Gln Leu Asp Ile Thr Leu Arg Arg Gly Gln Ser 
            260                 265                 270         


Leu Ala Ala Arg Asp Arg Gly Gly Thr Ser Asp Pro Tyr Val Lys Phe 
        275                 280                 285             


Lys Ile Gly Gly Lys Glu Val Phe Arg Ser Lys Ile Ile His Lys Asn 
    290                 295                 300                 


Leu Asn Pro Val Trp Glu Glu Lys Ala Cys Ile Leu Val Asp His Leu 
305                 310                 315                 320 


Arg Glu Pro Leu Tyr Ile Lys Val Phe Asp Tyr Asp Phe Gly Leu Gln 
                325                 330                 335     


Asp Asp Phe Met Gly Ser Ala Phe Leu Asp Leu Thr Gln Leu Glu Leu 
            340                 345                 350         


Asn Arg Pro Thr Asp Val Thr Leu Thr Leu Lys Asp Pro His Tyr Pro 
        355                 360                 365             


Asp His Asp Leu Gly Ile Ile Leu Leu Ser Val Ile Leu Thr Pro Lys 
    370                 375                 380                 


Glu Gly Glu Ser Arg Asp Val Thr Met Leu Met Arg Lys Ser Trp Lys 
385                 390                 395                 400 


Arg Ser Ser Lys Glu Leu Ser Glu Asn Glu Val Val Gly Ser Tyr Phe 
                405                 410                 415     


Ser Val Lys Ser Leu Phe Trp Arg Thr Cys Gly Arg Pro Ala Leu Pro 
            420                 425                 430         


Val Leu Gly Phe Cys Arg Ala Glu Leu Gln Asn Pro Tyr Cys Lys Asn 
        435                 440                 445             


Val Gln Phe Gln Thr Gln Ser Leu Arg Leu Ser Asp Leu His Arg Lys 
    450                 455                 460                 


Ser His Leu Trp Arg Gly Ile Val Ser Ile Thr Leu Ile Glu Gly Arg 
465                 470                 475                 480 


Asp Leu Lys Ala Met Asp Ser Asn Gly Leu Ser Asp Pro Tyr Val Lys 
                485                 490                 495     


Phe Arg Leu Gly His Gln Lys Tyr Lys Ser Lys Ile Met Pro Lys Thr 
            500                 505                 510         


Leu Asn Pro Gln Trp Arg Glu Gln Phe Asp Phe His Leu Tyr Glu Glu 
        515                 520                 525             


Arg Gly Gly Val Ile Asp Ile Thr Ala Trp Asp Lys Asp Ala Gly Lys 
    530                 535                 540                 


Arg Asp Asp Phe Ile Gly Arg Cys Gln Val Asp Leu Ser Ala Leu Ser 
545                 550                 555                 560 


Arg Glu Gln Thr His Lys Leu Glu Leu Gln Leu Glu Glu Gly Glu Gly 
                565                 570                 575     


His Leu Val Leu Leu Val Thr Leu Thr Ala Ser Ala Thr Val Ser Ile 
            580                 585                 590         


Ser Asp Leu Ser Val Asn Ser Leu Glu Asp Gln Lys Glu Arg Glu Glu 
        595                 600                 605             


Ile Leu Lys Arg Tyr Ser Pro Leu Arg Ile Phe His Asn Leu Lys Asp 
    610                 615                 620                 


Val Gly Phe Leu Gln Val Lys Val Ile Arg Ala Glu Gly Leu Met Ala 
625                 630                 635                 640 


Ala Asp Val Thr Gly Lys Ser Asp Pro Phe Cys Val Val Glu Leu Asn 
                645                 650                 655     


Asn Asp Arg Leu Leu Thr His Thr Val Tyr Lys Asn Leu Asn Pro Glu 
            660                 665                 670         


Trp Asn Lys Val Phe Thr Phe Asn Ile Lys Asp Ile His Ser Val Leu 
        675                 680                 685             


Glu Val Thr Val Tyr Asp Glu Asp Arg Asp Arg Ser Ala Asp Phe Leu 
    690                 695                 700                 


Gly Lys Val Ala Ile Pro Leu Leu Ser Ile Gln Asn Gly Glu Gln Lys 
705                 710                 715                 720 


Ala Tyr Val Leu Lys Asn Lys Gln Leu Thr Gly Pro Thr Lys Gly Val 
                725                 730                 735     


Ile Tyr Leu Glu Ile Asp Val Ile Phe Asn Ala Val Lys Ala Ser Leu 
            740                 745                 750         


Arg Thr Leu Ile Pro Lys Glu Gln Lys Tyr Ile Glu Glu Glu Asn Arg 
        755                 760                 765             


Leu Ser Lys Gln Leu Leu Leu Arg Asn Phe Ile Arg Met Lys Arg Cys 
    770                 775                 780                 


Val Met Val Leu Val Asn Ala Ala Tyr Tyr Val Asn Ser Cys Phe Asp 
785                 790                 795                 800 


Trp Asp Ser Pro Pro Arg Ser Leu Ala Ala Phe Val Leu Phe Leu Phe 
                805                 810                 815     


Val Val Trp Asn Phe Glu Leu Tyr Met Ile Pro Leu Val Leu Leu Leu 
            820                 825                 830         


Leu Leu Thr Trp Asn Tyr Phe Leu Ile Ile Ser Gly Lys Asp Asn Arg 
        835                 840                 845             


Gln Arg Asp Thr Val Val Glu Asp Met Leu Glu Asp Glu Glu Glu Glu 
    850                 855                 860                 


Asp Asp Lys Asp Asp Lys Asp Ser Glu Lys Lys Gly Phe Ile Asn Lys 
865                 870                 875                 880 


Ile Tyr Ala Ile Gln Glu Val Cys Val Ser Val Gln Asn Ile Leu Asp 
                885                 890                 895     


Glu Val Ala Ser Phe Gly Glu Arg Ile Lys Asn Thr Phe Asn Trp Thr 
            900                 905                 910         


Val Pro Phe Leu Ser Trp Leu Ala Ile Val Ala Leu Cys Val Phe Thr 
        915                 920                 925             


Ala Ile Leu Tyr Cys Ile Pro Leu Arg Tyr Ile Val Leu Val Trp Gly 
    930                 935                 940                 


Ile Asn Lys Phe Thr Lys Lys Leu Arg Ser Pro Tyr Ala Ile Asp Asn 
945                 950                 955                 960 


Asn Glu Leu Leu Asp Phe Leu Ser Arg Val Pro Ser Asp Val Gln Val 
                965                 970                 975     


Val Gln Tyr Gln Glu Leu Lys Pro Asp Pro Ser His Ser Pro Tyr Lys 
            980                 985                 990         


Arg Lys Lys Asn Asn Leu Gly 
        995                 


<210>  5071
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  5071

Met Gly Thr Glu Lys Glu Ser Pro Glu Pro Asp Cys Gln Lys Gln Phe 
1               5                   10                  15      


Gln Ala Ala Val Ser Val Ile Gln Asn Leu Pro Lys Asn Gly Ser Tyr 
            20                  25                  30          


Arg Pro Ser Tyr Glu Glu Met Leu Arg Phe Tyr Ser Tyr Tyr Lys Gln 
        35                  40                  45              


Ala Thr Met Gly Pro Cys Leu Val Pro Arg Pro Gly Phe Trp Asp Pro 
    50                  55                  60                  


Ile Gly Arg Tyr Lys Trp Asp Ala Trp Asn Ser Leu Gly Lys Met Ser 
65                  70                  75                  80  


Arg Glu Glu Ala Met Ser Ala Tyr Ile Thr Glu Met Lys Leu Val Ala 
                85                  90                  95      


Gln Lys Val Ile Asp Thr Val Pro Leu Gly Glu Val Ala Glu Asp Met 
            100                 105                 110         


Phe Gly Tyr Phe Glu Pro Leu Tyr Gln Val Ile Pro Asp Met Pro Arg 
        115                 120                 125             


Pro Pro Glu Thr Phe Leu Arg Arg Val Thr Gly Trp Lys Glu Gln Val 
    130                 135                 140                 


Val Asn Gly Asp Val Gly Ala Val Ser Glu Pro Pro Cys Leu Pro Lys 
145                 150                 155                 160 


Glu Pro Ala Pro Pro Ser Pro Glu Ser His Ser Pro Arg Asp Leu Asp 
                165                 170                 175     


Ser Glu Val Phe Cys Asp Ser Leu Glu Gln Leu Glu Pro Glu Leu Val 
            180                 185                 190         


Trp Thr Glu Gln Arg Ala Ala Ser Gly Gly Lys Arg Asp Pro Arg Asn 
        195                 200                 205             


Ser Pro Val Pro Pro Thr Lys Lys Glu Gly Leu Arg Gly Ser Pro Pro 
    210                 215                 220                 


Gly Pro Gln Glu Leu Asp Val Trp Leu Leu Gly Thr Val Arg Ala Leu 
225                 230                 235                 240 


Gln Glu Ser Met Gln Glu Val Gln Ala Arg Val Gln Ser Leu Glu Ser 
                245                 250                 255     


Met Pro Arg Pro Pro Glu Gln Arg Pro Gln Pro Arg Pro Ser Ala Arg 
            260                 265                 270         


Pro Trp Pro Leu Gly Leu Pro Gly Pro Ala Leu Leu Phe Phe Leu Leu 
        275                 280                 285             


Trp Pro Phe Val Val Gln Trp Leu Phe Arg Met Phe Arg Thr Gln Lys 
    290                 295                 300                 


Arg 
305 


<210>  5072
<211>  1002
<212>  PRT
<213>  Homo sapiens

<400>  5072

Met Ala Ala His Glu Trp Asp Trp Phe Gln Arg Glu Glu Leu Ile Gly 
1               5                   10                  15      


Gln Ile Ser Asp Ile Arg Val Gln Asn Leu Gln Val Glu Arg Glu Asn 
            20                  25                  30          


Val Gln Lys Arg Thr Phe Thr Arg Trp Ile Asn Leu His Leu Glu Lys 
        35                  40                  45              


Cys Asn Pro Pro Leu Glu Val Lys Asp Leu Phe Val Asp Ile Gln Asp 
    50                  55                  60                  


Gly Lys Ile Leu Met Ala Leu Leu Glu Val Leu Ser Gly Arg Asn Leu 
65                  70                  75                  80  


Leu His Glu Tyr Lys Ser Ser Ser His Arg Ile Phe Arg Leu Asn Asn 
                85                  90                  95      


Ile Ala Lys Ala Leu Lys Phe Leu Glu Asp Ser Asn Val Lys Leu Val 
            100                 105                 110         


Ser Ile Asp Ala Ala Glu Ile Ala Asp Gly Asn Pro Ser Leu Val Leu 
        115                 120                 125             


Gly Leu Ile Trp Asn Ile Ile Leu Phe Phe Gln Ile Lys Glu Leu Thr 
    130                 135                 140                 


Gly Asn Leu Ser Arg Asn Ser Pro Ser Ser Ser Leu Ser Pro Gly Ser 
145                 150                 155                 160 


Gly Gly Thr Asp Ser Asp Ser Ser Phe Pro Pro Thr Pro Thr Ala Glu 
                165                 170                 175     


Arg Ser Val Ala Ile Ser Val Lys Asp Gln Arg Lys Ala Ile Lys Ala 
            180                 185                 190         


Leu Leu Ala Trp Val Gln Arg Lys Thr Arg Lys Tyr Gly Val Ala Val 
        195                 200                 205             


Gln Asp Phe Ala Gly Ser Trp Arg Ser Gly Leu Ala Phe Leu Ala Val 
    210                 215                 220                 


Ile Lys Ala Ile Asp Pro Ser Leu Val Asp Met Lys Gln Ala Leu Glu 
225                 230                 235                 240 


Asn Ser Thr Arg Glu Asn Leu Glu Lys Ala Phe Ser Ile Ala Gln Asp 
                245                 250                 255     


Ala Leu His Ile Pro Arg Leu Leu Glu Pro Glu Asp Ile Met Val Asp 
            260                 265                 270         


Thr Pro Asp Glu Gln Ser Ile Met Thr Tyr Val Ala Gln Phe Leu Glu 
        275                 280                 285             


Arg Phe Pro Glu Leu Glu Ala Glu Asp Ile Phe Asp Ser Asp Lys Glu 
    290                 295                 300                 


Val Pro Ile Glu Ser Thr Phe Val Arg Ile Lys Glu Thr Pro Ser Glu 
305                 310                 315                 320 


Gln Glu Ser Lys Val Phe Val Leu Thr Glu Asn Gly Glu Arg Thr Tyr 
                325                 330                 335     


Thr Val Asn His Glu Thr Ser His Pro Pro Pro Ser Lys Val Phe Val 
            340                 345                 350         


Cys Asp Lys Pro Glu Ser Met Lys Glu Phe Arg Leu Asp Gly Val Ser 
        355                 360                 365             


Ser His Ala Leu Ser Asp Ser Ser Thr Glu Phe Met His Gln Ile Ile 
    370                 375                 380                 


Asp Gln Val Leu Gln Gly Gly Pro Gly Lys Thr Ser Asp Ile Ser Glu 
385                 390                 395                 400 


Pro Ser Pro Glu Ser Ser Ile Leu Ser Ser Arg Lys Glu Asn Gly Arg 
                405                 410                 415     


Ser Asn Ser Leu Pro Ile Lys Lys Thr Val His Phe Glu Ala Asp Thr 
            420                 425                 430         


Tyr Lys Asp Pro Phe Cys Ser Lys Asn Leu Ser Leu Cys Phe Glu Gly 
        435                 440                 445             


Ser Pro Arg Val Ala Lys Glu Ser Leu Arg Gln Asp Gly His Val Leu 
    450                 455                 460                 


Ala Val Glu Val Ala Glu Glu Lys Glu Gln Lys Gln Glu Ser Ser Lys 
465                 470                 475                 480 


Ile Pro Glu Ser Ser Ser Asp Lys Val Ala Gly Asp Ile Phe Leu Val 
                485                 490                 495     


Glu Gly Thr Asn Asn Asn Ser Gln Ser Ser Ser Cys Asn Gly Ala Leu 
            500                 505                 510         


Glu Ser Thr Ala Arg His Asp Glu Glu Ser His Ser Leu Ser Pro Pro 
        515                 520                 525             


Gly Glu Asn Thr Val Met Ala Asp Ser Phe Gln Ile Lys Val Asn Leu 
    530                 535                 540                 


Met Thr Val Glu Ala Leu Glu Glu Gly Asp Tyr Phe Glu Ala Ile Pro 
545                 550                 555                 560 


Leu Lys Ala Ser Lys Phe Asn Ser Asp Leu Ile Asp Phe Ala Ser Thr 
                565                 570                 575     


Ser Gln Ala Phe Asn Lys Val Pro Ser Pro His Glu Thr Lys Pro Asp 
            580                 585                 590         


Glu Asp Ala Glu Ala Phe Glu Asn His Ala Glu Lys Leu Gly Lys Arg 
        595                 600                 605             


Ser Ile Lys Ser Ala His Lys Lys Lys Asp Ser Pro Glu Pro Gln Val 
    610                 615                 620                 


Lys Met Asp Lys His Glu Pro His Gln Asp Ser Gly Glu Glu Ala Glu 
625                 630                 635                 640 


Gly Cys Pro Ser Ala Pro Glu Glu Thr Pro Val Asp Lys Lys Pro Glu 
                645                 650                 655     


Val His Glu Lys Ala Lys Arg Lys Ser Thr Arg Pro His Tyr Glu Glu 
            660                 665                 670         


Glu Gly Glu Asp Asp Asp Leu Gln Gly Val Gly Glu Glu Leu Ser Ser 
        675                 680                 685             


Ser Pro Pro Ser Ser Cys Val Ser Leu Glu Thr Leu Gly Ser His Ser 
    690                 695                 700                 


Glu Glu Gly Leu Asp Phe Lys Pro Ser Pro Pro Leu Ser Lys Val Ser 
705                 710                 715                 720 


Val Ile Pro His Asp Leu Phe Tyr Phe Pro His Tyr Glu Val Pro Leu 
                725                 730                 735     


Ala Ala Val Leu Glu Ala Tyr Val Glu Asp Pro Glu Asp Leu Lys Asn 
            740                 745                 750         


Glu Glu Met Asp Leu Glu Glu Pro Glu Gly Tyr Met Pro Asp Leu Asp 
        755                 760                 765             


Ser Arg Glu Glu Glu Ala Asp Gly Ser Gln Ser Ser Ser Ser Ser Ser 
    770                 775                 780                 


Val Pro Gly Glu Ser Leu Pro Ser Ala Ser Asp Gln Val Leu Tyr Leu 
785                 790                 795                 800 


Ser Arg Gly Gly Val Gly Thr Thr Pro Ala Ser Glu Pro Ala Pro Leu 
                805                 810                 815     


Ala Pro His Glu Asp His Gln Gln Arg Glu Thr Lys Glu Asn Asp Pro 
            820                 825                 830         


Met Asp Ser His Gln Ser Gln Glu Ser Pro Asn Leu Glu Asn Ile Ala 
        835                 840                 845             


Asn Pro Leu Glu Glu Asn Val Thr Lys Glu Ser Ile Ser Ser Lys Lys 
    850                 855                 860                 


Lys Glu Lys Arg Lys His Val Asp His Val Glu Ser Ser Leu Phe Val 
865                 870                 875                 880 


Ala Pro Gly Ser Val Gln Ser Ser Asp Asp Leu Glu Glu Asp Ser Ser 
                885                 890                 895     


Asp Tyr Ser Ile Pro Ser Arg Thr Ser His Ser Asp Ser Ser Ile Tyr 
            900                 905                 910         


Leu Arg Arg His Thr His Arg Ser Ser Glu Ser Asp His Phe Ser Tyr 
        915                 920                 925             


Val Gln Leu Arg Asn Ala Ala Asp Leu Asp Asp Arg Arg Asn Arg Ile 
    930                 935                 940                 


Leu Thr Arg Lys Ala Asn Ser Ser Gly Glu Ala Met Ser Leu Gly Ser 
945                 950                 955                 960 


His Ser Pro Gln Ser Asp Ser Leu Thr Gln Leu Val Gln Gln Pro Asp 
                965                 970                 975     


Met Met Tyr Phe Ile Leu Phe Leu Trp Leu Leu Val Tyr Cys Leu Leu 
            980                 985                 990         


Leu Phe Pro Gln Leu Asp Val Ser  Arg Leu 
        995                 1000         


<210>  5073
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  5073

Met Val Asn Leu Ala Ala Met Val Trp Arg Arg Leu Leu Arg Lys Arg 
1               5                   10                  15      


Trp Val Leu Ala Leu Val Phe Gly Leu Ser Leu Val Tyr Phe Leu Ser 
            20                  25                  30          


Ser Thr Phe Lys Gln Glu Glu Arg Ala Val Arg Asp Arg Asn Leu Leu 
        35                  40                  45              


Gln Val His Asp His Asn Gln Pro Ile Pro Trp Lys Val Gln Phe Asn 
    50                  55                  60                  


Leu Gly Asn Ser Ser Arg Pro Ser Asn Gln Cys Arg Asn Ser Ile Gln 
65                  70                  75                  80  


Gly Lys His Leu Ile Thr Asp Glu Leu Gly Tyr Val Cys Glu Arg Lys 
                85                  90                  95      


Asp Leu Leu Val Asn Gly Cys Cys Asn Val Asn Val Pro Ser Thr Lys 
            100                 105                 110         


Gln Tyr Cys Cys Asp Gly Cys Trp Pro Asn Gly Cys Cys Ser Ala Tyr 
        115                 120                 125             


Glu Tyr Cys Val Ser Cys Cys Leu Gln Pro Asn Lys Gln Leu Leu Leu 
    130                 135                 140                 


Glu Arg Phe Leu Asn Arg Ala Ala Val Ala Phe Gln Asn Leu Phe Met 
145                 150                 155                 160 


Ala Val Glu Asp His Phe Glu Leu Cys Leu Ala Lys Cys Arg Thr Ser 
                165                 170                 175     


Ser Gln Ser Val Gln His Glu Asn Thr Tyr Arg Asp Pro Ile Ala Lys 
            180                 185                 190         


Tyr Cys Tyr Gly Glu Ser Pro Pro Glu Leu Phe Pro Ala 
        195                 200                 205 


<210>  5074
<211>  618
<212>  PRT
<213>  Homo sapiens

<400>  5074

Met Ala Ser Arg Gly Ala Arg Gln Arg Leu Lys Gly Ser Gly Ala Ser 
1               5                   10                  15      


Ser Gly Asp Thr Ala Pro Ala Ala Asp Lys Leu Arg Glu Leu Leu Gly 
            20                  25                  30          


Ser Arg Glu Ala Gly Gly Ala Glu His Arg Thr Glu Leu Ser Gly Asn 
        35                  40                  45              


Lys Ala Gly Gln Val Trp Ala Pro Glu Gly Ser Thr Ala Phe Lys Cys 
    50                  55                  60                  


Leu Leu Ser Ala Arg Leu Cys Ala Ala Leu Leu Ser Asn Ile Ser Asp 
65                  70                  75                  80  


Cys Asp Glu Thr Phe Asn Tyr Trp Glu Pro Thr His Tyr Leu Ile Tyr 
                85                  90                  95      


Gly Glu Gly Phe Gln Thr Trp Glu Tyr Ser Pro Ala Tyr Ala Ile Arg 
            100                 105                 110         


Ser Tyr Ala Tyr Leu Leu Leu His Ala Trp Pro Ala Ala Phe His Ala 
        115                 120                 125             


Arg Ile Leu Gln Thr Asn Lys Ile Leu Val Phe Tyr Phe Leu Arg Cys 
    130                 135                 140                 


Leu Leu Ala Phe Val Ser Cys Ile Cys Glu Leu Tyr Phe Tyr Lys Ala 
145                 150                 155                 160 


Val Cys Lys Lys Phe Gly Leu His Val Ser Arg Met Met Leu Ala Phe 
                165                 170                 175     


Leu Val Leu Ser Thr Gly Met Phe Cys Ser Ser Ser Ala Phe Leu Pro 
            180                 185                 190         


Ser Ser Phe Cys Met Tyr Thr Thr Leu Ile Ala Met Thr Gly Trp Tyr 
        195                 200                 205             


Met Asp Lys Thr Ser Ile Ala Val Leu Gly Val Ala Ala Gly Ala Ile 
    210                 215                 220                 


Leu Gly Trp Pro Phe Ser Ala Ala Leu Gly Leu Pro Ile Ala Phe Asp 
225                 230                 235                 240 


Leu Leu Val Met Lys His Arg Trp Lys Ser Phe Phe His Trp Ser Leu 
                245                 250                 255     


Met Ala Leu Ile Leu Phe Leu Val Pro Val Val Val Ile Asp Ser Tyr 
            260                 265                 270         


Tyr Tyr Gly Lys Leu Val Ile Ala Pro Leu Asn Ile Val Leu Tyr Asn 
        275                 280                 285             


Val Phe Thr Pro His Gly Pro Asp Leu Tyr Gly Thr Glu Pro Trp Tyr 
    290                 295                 300                 


Phe Tyr Leu Ile Asn Gly Phe Leu Asn Phe Asn Val Ala Phe Ala Leu 
305                 310                 315                 320 


Ala Leu Leu Val Leu Pro Leu Thr Ser Leu Met Glu Tyr Leu Leu Gln 
                325                 330                 335     


Arg Phe His Val Gln Asn Leu Gly His Pro Tyr Trp Leu Thr Leu Ala 
            340                 345                 350         


Pro Met Tyr Ile Trp Phe Ile Ile Phe Phe Ile Gln Pro His Lys Glu 
        355                 360                 365             


Glu Arg Phe Leu Phe Pro Val Tyr Pro Leu Ile Cys Leu Cys Gly Ala 
    370                 375                 380                 


Val Ala Leu Ser Ala Leu Gln His Ser Phe Leu Tyr Phe Gln Lys Cys 
385                 390                 395                 400 


Tyr His Phe Val Phe Gln Arg Tyr Arg Leu Glu His Tyr Thr Val Thr 
                405                 410                 415     


Ser Asn Trp Leu Ala Leu Gly Thr Val Phe Leu Phe Gly Leu Leu Ser 
            420                 425                 430         


Phe Ser Arg Ser Val Ala Leu Phe Arg Gly Tyr His Gly Pro Leu Asp 
        435                 440                 445             


Leu Tyr Pro Glu Phe Tyr Arg Ile Ala Thr Asp Pro Thr Ile His Thr 
    450                 455                 460                 


Val Pro Glu Gly Arg Pro Val Asn Val Cys Val Gly Lys Glu Trp Tyr 
465                 470                 475                 480 


Arg Phe Pro Ser Ser Phe Leu Leu Pro Asp Asn Trp Gln Leu Gln Phe 
                485                 490                 495     


Ile Pro Ser Glu Phe Arg Gly Gln Leu Pro Lys Pro Phe Ala Glu Gly 
            500                 505                 510         


Pro Leu Ala Thr Arg Ile Val Pro Thr Asp Met Asn Asp Gln Asn Leu 
        515                 520                 525             


Glu Glu Pro Ser Arg Tyr Ile Asp Ile Ser Lys Cys His Tyr Leu Val 
    530                 535                 540                 


Asp Leu Asp Thr Met Arg Glu Thr Pro Arg Glu Pro Lys Tyr Ser Ser 
545                 550                 555                 560 


Asn Lys Glu Glu Trp Ile Ser Leu Ala Tyr Arg Pro Phe Leu Asp Ala 
                565                 570                 575     


Ser Arg Ser Ser Lys Leu Leu Arg Ala Phe Tyr Val Pro Phe Leu Ser 
            580                 585                 590         


Asp Gln Tyr Thr Val Tyr Val Asn Tyr Thr Ile Leu Lys Pro Arg Lys 
        595                 600                 605             


Ala Lys Gln Ile Arg Lys Lys Ser Gly Gly 
    610                 615             


<210>  5075
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  5075

Met Arg Ser Asp Lys Ser Ala Leu Val Phe Leu Leu Leu Gln Leu Phe 
1               5                   10                  15      


Cys Val Gly Cys Gly Phe Cys Gly Lys Val Leu Val Trp Pro Cys Asp 
            20                  25                  30          


Met Ser His Trp Leu Asn Val Lys Val Ile Leu Glu Glu Leu Ile Val 
        35                  40                  45              


Arg Gly His Glu Val Thr Val Leu Thr His Ser Lys Pro Ser Leu Ile 
    50                  55                  60                  


Asp Tyr Arg Lys Pro Ser Ala Leu Lys Phe Glu Val Val His Met Pro 
65                  70                  75                  80  


Gln Asp Arg Thr Glu Glu Asn Glu Ile Phe Val Asp Leu Ala Leu Asn 
                85                  90                  95      


Val Leu Pro Gly Leu Ser Thr Trp Gln Ser Val Ile Lys Leu Asn Asp 
            100                 105                 110         


Phe Phe Val Glu Ile Arg Gly Thr Leu Lys Met Met Cys Glu Ser Phe 
        115                 120                 125             


Ile Tyr Asn Gln Thr Leu Met Lys Lys Leu Gln Glu Thr Asn Tyr Asp 
    130                 135                 140                 


Val Met Leu Ile Asp Pro Val Ile Pro Cys Gly Asp Leu Met Ala Glu 
145                 150                 155                 160 


Leu Leu Ala Val Pro Phe Val Leu Thr Leu Arg Ile Ser Val Gly Gly 
                165                 170                 175     


Asn Met Glu Arg Ser Cys Gly Lys Leu Pro Ala Pro Leu Ser Tyr Val 
            180                 185                 190         


Pro Val Pro Met Thr Gly Leu Thr Asp Arg Met Thr Phe Leu Glu Arg 
        195                 200                 205             


Val Lys Asn Ser Met Leu Ser Val Leu Phe His Phe Trp Ile Gln Asp 
    210                 215                 220                 


Tyr Asp Tyr His Phe Trp Glu Glu Phe Tyr Ser Lys Ala Leu Gly Arg 
225                 230                 235                 240 


Pro Thr Thr Leu Cys Glu Thr Val Gly Lys Ala Glu Ile Trp Leu Ile 
                245                 250                 255     


Arg Thr Tyr Trp Asp Phe Glu Phe Pro Gln Pro Tyr Gln Pro Asn Phe 
            260                 265                 270         


Glu Phe Val Gly Gly Leu His Cys Lys Pro Ala Lys Ala Leu Pro Lys 
        275                 280                 285             


Glu Met Glu Asn Phe Val Gln Ser Ser Gly Glu Asp Gly Ile Val Val 
    290                 295                 300                 


Phe Ser Leu Gly Ser Leu Phe Gln Asn Val Thr Glu Glu Lys Ala Asn 
305                 310                 315                 320 


Ile Ile Ala Ser Ala Leu Ala Gln Ile Pro Gln Lys Val Leu Trp Arg 
                325                 330                 335     


Tyr Lys Gly Lys Lys Pro Ser Thr Leu Gly Ala Asn Thr Arg Leu Tyr 
            340                 345                 350         


Asp Trp Ile Pro Gln Asn Asp Leu Leu Gly His Pro Lys Thr Lys Ala 
        355                 360                 365             


Phe Ile Thr His Gly Gly Met Asn Gly Ile Tyr Glu Ala Ile Tyr His 
    370                 375                 380                 


Gly Val Pro Met Val Gly Val Pro Ile Phe Gly Asp Gln Leu Asp Asn 
385                 390                 395                 400 


Ile Ala His Met Lys Ala Lys Gly Ala Ala Val Glu Ile Asn Phe Lys 
                405                 410                 415     


Thr Met Thr Ser Glu Asp Leu Leu Arg Ala Leu Arg Thr Val Ile Thr 
            420                 425                 430         


Asp Ser Ser Tyr Lys Glu Asn Ala Met Arg Leu Ser Arg Ile His His 
        435                 440                 445             


Asp Gln Pro Val Lys Pro Leu Asp Arg Ala Val Phe Trp Ile Glu Phe 
    450                 455                 460                 


Val Met Arg His Lys Gly Ala Lys His Leu Arg Ser Ala Ala His Asp 
465                 470                 475                 480 


Leu Thr Trp Phe Gln His Tyr Ser Ile Asp Val Ile Gly Phe Leu Leu 
                485                 490                 495     


Ala Cys Val Ala Thr Ala Ile Phe Leu Phe Thr Lys Cys Phe Leu Phe 
            500                 505                 510         


Ser Cys Gln Lys Phe Asn Lys Thr Arg Lys Ile Glu Lys Arg Glu 
        515                 520                 525         


<210>  5076
<211>  724
<212>  PRT
<213>  Homo sapiens

<400>  5076

Met Leu Arg Thr Ser Thr Pro Asn Leu Cys Gly Gly Leu His Cys Arg 
1               5                   10                  15      


Ala Pro Trp Leu Ser Ser Gly Ile Leu Cys Leu Cys Leu Ile Phe Leu 
            20                  25                  30          


Leu Gly Gln Val Gly Leu Leu Gln Gly His Pro Gln Cys Leu Asp Tyr 
        35                  40                  45              


Gly Pro Pro Phe Gln Pro Pro Leu His Leu Glu Phe Cys Ser Asp Tyr 
    50                  55                  60                  


Glu Ser Phe Gly Cys Cys Asp Gln His Lys Asp Arg Arg Ile Ala Ala 
65                  70                  75                  80  


Arg Tyr Trp Asp Ile Met Glu Tyr Phe Asp Leu Lys Arg His Glu Leu 
                85                  90                  95      


Cys Gly Asp Tyr Ile Lys Asp Ile Leu Cys Gln Glu Cys Ser Pro Tyr 
            100                 105                 110         


Ala Ala His Leu Tyr Asp Ala Glu Asn Thr Gln Thr Pro Leu Arg Asn 
        115                 120                 125             


Leu Pro Gly Leu Cys Ser Asp Tyr Cys Ser Ala Phe His Ser Asn Cys 
    130                 135                 140                 


His Ser Ala Ile Ser Leu Leu Thr Asn Asp Arg Gly Leu Gln Glu Ser 
145                 150                 155                 160 


His Gly Arg Asp Gly Thr Arg Phe Cys His Leu Leu Asp Leu Pro Asp 
                165                 170                 175     


Lys Asp Tyr Cys Phe Pro Asn Val Leu Arg Asn Asp Tyr Leu Asn Arg 
            180                 185                 190         


His Leu Gly Met Val Ala Gln Asp Pro Gln Gly Cys Leu Gln Leu Cys 
        195                 200                 205             


Leu Ser Glu Val Ala Asn Gly Leu Arg Asn Pro Val Ser Met Val His 
    210                 215                 220                 


Ala Gly Asp Gly Thr His Arg Phe Phe Val Ala Glu Gln Val Gly Val 
225                 230                 235                 240 


Val Trp Val Tyr Leu Pro Asp Gly Ser Arg Leu Glu Gln Pro Phe Leu 
                245                 250                 255     


Asp Leu Lys Asn Ile Val Leu Thr Thr Pro Trp Ile Gly Asp Glu Arg 
            260                 265                 270         


Gly Phe Leu Gly Leu Ala Phe His Pro Lys Phe Arg His Asn Arg Lys 
        275                 280                 285             


Phe Tyr Ile Tyr Tyr Ser Cys Leu Asp Lys Lys Lys Val Glu Lys Ile 
    290                 295                 300                 


Arg Ile Ser Glu Met Lys Val Ser Arg Ala Asp Pro Asn Lys Ala Asp 
305                 310                 315                 320 


Leu Lys Ser Glu Arg Val Ile Leu Glu Ile Glu Glu Pro Ala Ser Asn 
                325                 330                 335     


His Asn Gly Gly Gln Leu Leu Phe Gly Leu Asp Gly Tyr Met Tyr Ile 
            340                 345                 350         


Phe Thr Gly Asp Gly Gly Gln Ala Gly Asp Pro Phe Gly Leu Phe Gly 
        355                 360                 365             


Asn Ala Gln Asn Lys Ser Ser Leu Leu Gly Lys Val Leu Arg Ile Asp 
    370                 375                 380                 


Val Asn Arg Ala Gly Ser His Gly Lys Arg Tyr Arg Val Pro Ser Asp 
385                 390                 395                 400 


Asn Pro Phe Val Ser Glu Pro Gly Ala His Pro Ala Ile Tyr Ala Tyr 
                405                 410                 415     


Gly Ile Arg Asn Met Trp Arg Cys Ala Val Asp Arg Gly Asp Pro Ile 
            420                 425                 430         


Thr Arg Gln Gly Arg Gly Arg Ile Phe Cys Gly Asp Val Gly Gln Asn 
        435                 440                 445             


Arg Phe Glu Glu Val Asp Leu Ile Leu Lys Gly Gly Asn Tyr Gly Trp 
    450                 455                 460                 


Arg Ala Lys Glu Gly Phe Ala Cys Tyr Asp Lys Lys Leu Cys His Asn 
465                 470                 475                 480 


Ala Ser Leu Asp Asp Val Leu Pro Ile Tyr Ala Tyr Gly His Ala Val 
                485                 490                 495     


Gly Lys Ser Val Thr Gly Gly Tyr Val Tyr Arg Gly Cys Glu Ser Pro 
            500                 505                 510         


Asn Leu Asn Gly Leu Tyr Ile Phe Gly Asp Phe Met Ser Gly Arg Leu 
        515                 520                 525             


Met Ala Leu Gln Glu Asp Arg Lys Asn Lys Lys Trp Lys Lys Gln Asp 
    530                 535                 540                 


Leu Cys Leu Gly Ser Thr Thr Ser Cys Ala Phe Pro Gly Leu Ile Ser 
545                 550                 555                 560 


Thr His Ser Lys Phe Ile Ile Ser Phe Ala Glu Asp Glu Ala Gly Glu 
                565                 570                 575     


Leu Tyr Phe Leu Ala Thr Ser Tyr Pro Ser Ala Tyr Ala Pro Arg Gly 
            580                 585                 590         


Ser Ile Tyr Lys Phe Val Asp Pro Ser Arg Arg Ala Pro Pro Gly Lys 
        595                 600                 605             


Cys Lys Tyr Lys Pro Val Pro Val Arg Thr Lys Ser Lys Arg Ile Pro 
    610                 615                 620                 


Phe Arg Pro Leu Ala Lys Thr Val Leu Asp Leu Leu Lys Glu Gln Ser 
625                 630                 635                 640 


Glu Lys Ala Ala Arg Lys Ser Ser Ser Ala Thr Leu Ala Ser Gly Pro 
                645                 650                 655     


Ala Gln Gly Leu Ser Glu Lys Gly Ser Ser Lys Lys Leu Ala Ser Pro 
            660                 665                 670         


Thr Ser Ser Lys Asn Thr Leu Arg Gly Pro Gly Thr Lys Lys Lys Ala 
        675                 680                 685             


Arg Val Gly Pro His Val Arg Gln Gly Lys Arg Arg Lys Ser Leu Lys 
    690                 695                 700                 


Ser His Ser Gly Arg Met Arg Pro Ser Ala Glu Gln Lys Arg Ala Gly 
705                 710                 715                 720 


Arg Ser Leu Pro 
                


<210>  5077
<211>  368
<212>  PRT
<213>  Homo sapiens

<400>  5077

Met Ala Ala Val Ala Pro Ala Gly Pro Gly Asp Ser Ala Ser Ala Ala 
1               5                   10                  15      


Leu Asp Glu Leu Ser Leu Asn Phe Thr Tyr Gly Ala Pro Gly Ala Gly 
            20                  25                  30          


Asn Gly Ser Leu Ser Gly Asp Trp Tyr Arg Arg Asn Gln Ile His Leu 
        35                  40                  45              


Phe Gly Val Leu Leu Ala Ile Leu Gly Asn Leu Val Ile Ser Ile Ser 
    50                  55                  60                  


Leu Asn Ile Gln Lys Tyr Ser His Leu Gln Leu Ala Gln Gln Glu His 
65                  70                  75                  80  


Pro Arg Pro Tyr Phe Lys Ser Val Leu Trp Trp Gly Gly Val Leu Leu 
                85                  90                  95      


Met Ala Val Gly Glu Thr Gly Asn Phe Ala Ala Tyr Gly Phe Ala Pro 
            100                 105                 110         


Ile Thr Leu Ile Ala Pro Leu Gly Cys Val Ser Val Thr Gly Ser Ala 
        115                 120                 125             


Ile Ile Ser Val Thr Phe Leu Lys Asp Asn Leu Arg Ala Ser Asp Leu 
    130                 135                 140                 


Leu Gly Thr Thr Leu Ala Phe Ala Gly Thr Tyr Leu Leu Val Asn Phe 
145                 150                 155                 160 


Ala Pro Asn Ile Thr Gln Ala Ile Ser Ala Arg Thr Val Gln Tyr Tyr 
                165                 170                 175     


Leu Val Gly Trp Gln Phe Leu Ile Tyr Val Ile Leu Glu Ile Leu Ile 
            180                 185                 190         


Phe Cys Ile Leu Leu Tyr Phe Tyr Lys Arg Lys Gly Met Lys His Met 
        195                 200                 205             


Val Ile Leu Leu Thr Leu Val Ala Ile Leu Ala Ser Leu Thr Val Ile 
    210                 215                 220                 


Ser Val Lys Ala Val Ser Gly Met Ile Thr Phe Ser Val Met Asp Lys 
225                 230                 235                 240 


Met Gln Leu Thr Tyr Pro Ile Phe Tyr Ile Met Phe Ile Ile Met Ile 
                245                 250                 255     


Ala Ser Cys Val Phe Gln Val Lys Phe Leu Asn Gln Ala Thr Lys Leu 
            260                 265                 270         


Tyr Asn Thr Thr Thr Val Val Pro Val Asn His Ile Phe Phe Thr Ile 
        275                 280                 285             


Ser Ala Ile Ile Ala Gly Ile Ile Phe Tyr Gln Glu Phe Leu Gly Ala 
    290                 295                 300                 


Pro Phe Leu Thr Val Phe Ile Tyr Leu Phe Gly Cys Phe Leu Ser Phe 
305                 310                 315                 320 


Leu Gly Val Phe Leu Val Thr Arg Asn Arg Glu Lys Glu His Leu Gln 
                325                 330                 335     


Gln Ser Tyr Ile Asp Phe Gly Asn Ile Pro Asp Thr Thr Pro Glu Arg 
            340                 345                 350         


Lys Ala Trp Arg Glu Thr Asn Val Gly Gln Asn Thr Thr Arg Phe Thr 
        355                 360                 365             


<210>  5078
<211>  1116
<212>  PRT
<213>  Homo sapiens

<400>  5078

Met Glu Ser Pro Leu Ile Tyr Val Ser Val Leu Leu Leu Asn Ile Phe 
1               5                   10                  15      


Glu Phe Ser Ser Gly Ile Val Tyr Asn Lys Asp Asp Thr Glu Lys Arg 
            20                  25                  30          


Phe Ala Cys Ser Asn Lys Gly Phe Pro Gln Glu Asn Glu Ile Ile Lys 
        35                  40                  45              


Leu Tyr Leu Phe Leu Glu Asn Leu Lys Ile Gln Cys Phe Phe Gln Thr 
    50                  55                  60                  


Glu Asn Glu Ile Ala Ser Lys Ala Met Leu Ser Val Phe Thr Ser Gly 
65                  70                  75                  80  


Gly Leu Ala Pro Ser Leu Gly Ile Met Asn Ser Thr Tyr Asn Gly Ile 
                85                  90                  95      


Phe His Phe Asn Leu Thr Leu Phe Ser Asp Arg Ile Leu Trp Leu Val 
            100                 105                 110         


Asp Ile Pro Arg Glu Asn Ile Thr Gln Ser Thr Asp Ile Ala Ala Val 
        115                 120                 125             


Glu Glu Trp Leu Val Arg Ile Thr Leu His His Gly Leu Asn Ile Tyr 
    130                 135                 140                 


Ala Thr Glu Gly Thr Leu Leu Asp Val Ile Arg Glu Pro Ile Leu Gln 
145                 150                 155                 160 


Trp Thr Pro Gly Asp Val Ile Pro Glu Ser Glu Ile Ser Lys Leu Tyr 
                165                 170                 175     


Pro His Val Val Asp Leu Lys Val Thr Lys Cys Pro Cys Ala Asn Asp 
            180                 185                 190         


Val Ala Leu Leu Gly Phe Ile Val Asp Thr Ile Val Asp Gly Val Tyr 
        195                 200                 205             


Ile Gly Ile Thr Phe Gly Gly Phe Trp His Asp Tyr Asp Thr Thr Trp 
    210                 215                 220                 


Phe Asn Met Thr Gln Thr Ile Tyr Ser Gln Leu Gln Glu Glu Tyr Glu 
225                 230                 235                 240 


Asp Leu Ser Leu Val Asp Met Val Leu Thr Asn His Phe Leu Val Ile 
                245                 250                 255     


Leu Thr Ser Leu Gly Leu Phe Val Ser Glu Asp Leu Arg Tyr Pro Ser 
            260                 265                 270         


Arg His Ser Leu Ser Phe Ser Arg Ala Asp Phe Cys Gly Phe Glu Arg 
        275                 280                 285             


Val Asp Tyr Val Lys Gly Lys Leu Trp Tyr Asn Glu Arg Cys Phe Ala 
    290                 295                 300                 


Asn Arg Glu His Phe Glu Val Asp Tyr Val Thr Val Thr Phe Glu Arg 
305                 310                 315                 320 


Asn Arg Thr Leu Ser Glu Ser Ser Ser Cys Phe Tyr Ser Gln Glu Pro 
                325                 330                 335     


Phe Leu Glu Trp Val Pro Cys Leu Pro His Ile Phe Lys Gly Ile Lys 
            340                 345                 350         


Ile Phe Pro Thr Val Leu Thr Phe Leu Val Asp Gln Glu Arg Gly Thr 
        355                 360                 365             


Gly Val Tyr Leu Phe Tyr Asn Lys Val Arg Lys Thr Ala Ile Ala Ser 
    370                 375                 380                 


Val Ser Thr Leu Arg Asn Asn Glu Pro Asn Ser Gln Ser Lys Phe Pro 
385                 390                 395                 400 


Ile Phe Arg Phe Pro Ser Ser Phe Ser Ser Pro Val Gly Met Val Phe 
                405                 410                 415     


His Pro Arg Ser His Phe Leu Tyr Ala Tyr Gly Asn Gln Ile Trp Leu 
            420                 425                 430         


Ser Val Asp Gly Gly Asn Thr Phe Gln Leu Ile Ala Asn Phe His Asp 
        435                 440                 445             


Asp Ile Ile Lys Lys Thr Phe His Ser Phe Tyr Thr Ser Ala Ile Thr 
    450                 455                 460                 


Phe Val Ser Gln Arg Gly Lys Val Tyr Ser Thr Lys Ala Gly Met Gly 
465                 470                 475                 480 


Arg Tyr Ser Ala Val Gly Ser Val Thr Glu Arg Ile Phe Thr Leu Tyr 
                485                 490                 495     


Tyr Asp His Leu Gly Phe Leu His Lys Leu Thr Leu Gly Arg Phe Glu 
            500                 505                 510         


Ala Ser Gly Pro Pro Thr Ala Phe Gly Asn Ser Arg Asn Leu Phe Gly 
        515                 520                 525             


Gln Pro Pro Asp Met Gly Phe Glu Thr Ala Leu Ala Pro Gln His Thr 
    530                 535                 540                 


Ser Leu Asp Glu Ile Ile Phe Phe Ala Tyr Val Pro Glu Asn Glu Pro 
545                 550                 555                 560 


Gln Glu Thr Ile Tyr Ser Lys Lys Phe Gly Asn Ile His Tyr Gly Lys 
                565                 570                 575     


Val Ile His Ser Gly Lys Thr Gly Arg Ala Tyr Ile Arg Lys Val Leu 
            580                 585                 590         


Gln His Thr Thr Pro Lys Gly Phe Leu Ser Ser Val Ile Ala Glu Met 
        595                 600                 605             


Lys Glu Pro Phe Gly Leu Glu Glu Val Asn Glu Ser Ser Cys Leu Ser 
    610                 615                 620                 


Ser Ser Leu Leu Ile Asn Lys Ala Gly Asn Val Tyr Lys Leu Thr Leu 
625                 630                 635                 640 


Asp Ser Gln Val Val Gln Ala Leu Phe Glu Asp Thr Asp Ile Glu Lys 
                645                 650                 655     


Thr Val Val Leu Pro Gly Tyr Ser Ser Phe Leu Ile Thr Ser Ile Leu 
            660                 665                 670         


Asp Asn Lys Asn Ala Leu Ala Ile Ala Thr Met Pro Glu Ser Ala Pro 
        675                 680                 685             


Asn Asn Met Thr Phe Leu Lys Ser Thr Trp Phe Leu Tyr Asn Phe Gly 
    690                 695                 700                 


Gln Arg Asn Gly Arg Thr Trp Lys Ile Tyr Ser Lys Pro Cys Asn Tyr 
705                 710                 715                 720 


Trp Phe Gln His Asp Asp Ser Pro Ser Leu Asn Ile Val Lys Tyr Ile 
                725                 730                 735     


Asp Leu Gly Asn Ser Tyr Val Leu Lys Ala Lys Val Ile Arg Asn Ala 
            740                 745                 750         


Lys Gly Phe Arg Met Leu Glu Ile Pro Leu Leu Thr Val Phe Val Gly 
        755                 760                 765             


Asn Pro Asn Leu Leu Glu Val Thr Ala Glu Val Thr Phe Asp Asp Thr 
    770                 775                 780                 


Asp Ser Tyr Val Ile Thr Ile Ser Ala Ala Ser Lys Val Leu His Gln 
785                 790                 795                 800 


Gly Ser Thr Ser Leu Ala Phe Ile Met Trp Ser Ala Ser Thr Glu Cys 
                805                 810                 815     


Phe Val Thr Thr Met Val Pro Thr Leu Lys Ser Ser Cys Ser Tyr Leu 
            820                 825                 830         


Arg Ser Met His His Ile Pro Ser Lys Phe Ile Pro Phe Glu Asp Trp 
        835                 840                 845             


Ile Ser Gly Val His Lys Asp Ser Gln Gly Phe Asn Leu Ile Lys Thr 
    850                 855                 860                 


Leu Pro Ile Asn Tyr Arg Pro Pro Ser Asn Met Gly Ile Ala Ile Pro 
865                 870                 875                 880 


Leu Thr Asp Asn Phe Tyr His Ala Asp Pro Ser Lys Pro Ile Pro Arg 
                885                 890                 895     


Asn Met Phe His Met Ser Lys Lys Thr Gly Lys Phe Lys Gln Cys Ala 
            900                 905                 910         


Asn Val Ser Thr Arg Glu Glu Cys Asn Cys Thr Lys Asp Gln Lys Phe 
        915                 920                 925             


Ser His Ala Val Ala Phe Ser Asp Cys Arg Glu Lys Val Pro Arg Phe 
    930                 935                 940                 


Lys Phe Pro Ile Thr Gln Tyr Pro Val Ser Leu Glu Ile Ile Asn Glu 
945                 950                 955                 960 


Asp Gly Arg Val Pro Leu Gln Ser Pro Tyr Leu Val Thr Val Thr Glu 
                965                 970                 975     


Val Asn Met Arg His Asn Trp Lys Leu Lys His Thr Val Pro Glu Asn 
            980                 985                 990         


Ile Lys Arg Met Lys Gln Leu Val  Glu Pro Ile Leu Gly  Ala Ala Val 
        995                 1000                 1005             


Tyr Asn  Pro Ser Gly Leu Asn  Leu Ser Ile Lys Gly  Ser Glu Leu 
    1010                 1015                 1020             


Phe His  Phe Arg Val Thr Val  Ile Ser Gly Val Thr  Phe Cys Asn 
    1025                 1030                 1035             


Leu Ile  Glu Glu Phe Gln Ile  Tyr Val Asp Glu Ala  Pro Leu Pro 
    1040                 1045                 1050             


Phe Pro  Gly His Thr Leu Ile  Ala Val Ala Thr Ala  Val Val Leu 
    1055                 1060                 1065             


Gly Gly  Leu Ile Phe Ile Ala  Phe Met Phe Gln Leu  Gln Gly Ile 
    1070                 1075                 1080             


His Pro  Trp Arg Thr Phe Gln  Arg Trp Ile Arg Arg  Asn Gln Glu 
    1085                 1090                 1095             


Lys Phe  Ser Ser Ile Ser Leu  Ser Glu Leu Ile His  Arg Ser Lys 
    1100                 1105                 1110             


Ser Glu  Glu 
    1115     


<210>  5079
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  5079

Met Glu Ser Arg Val Ala Asp Ala Gly Thr Gly Glu Thr Ala Arg Ala 
1               5                   10                  15      


Ala Gly Gly Ser Pro Ala Val Gly Cys Thr Thr Arg Gly Pro Val Val 
            20                  25                  30          


Ser Ala Pro Leu Gly Ala Ala Arg Trp Lys Leu Leu Arg Gln Val Leu 
        35                  40                  45              


Lys Gln Lys His Leu Asp Asp Cys Leu Arg His Val Ser Val Arg Arg 
    50                  55                  60                  


Phe Glu Ser Phe Asn Leu Phe Ser Val Thr Glu Gly Lys Glu Arg Glu 
65                  70                  75                  80  


Thr Glu Glu Glu Val Gly Ala Trp Val Gln Tyr Thr Ser Ile Phe Cys 
                85                  90                  95      


Pro Glu Tyr Ser Ile Ser Leu Arg His Asn Ser Gly Ser Leu Asn Val 
            100                 105                 110         


Glu Asp Val Leu Thr Ser Phe Asp Asn Thr Gly Asn Val Cys Ile Trp 
        115                 120                 125             


Pro Ser Glu Glu Val Leu Ala Tyr Tyr Cys Leu Lys His Asn Asn Ile 
    130                 135                 140                 


Phe Arg Ala Leu Ala Val Cys Glu Leu Gly Gly Gly Met Thr Cys Leu 
145                 150                 155                 160 


Ala Gly Leu Met Val Ala Ile Ser Ala Asp Val Lys Glu Val Leu Leu 
                165                 170                 175     


Thr Asp Gly Asn Glu Lys Ala Ile Arg Asn Val Gln Asp Ile Ile Thr 
            180                 185                 190         


Arg Asn Gln Lys Ala Gly Val Phe Lys Thr Gln Lys Ile Ser Ser Cys 
        195                 200                 205             


Val Leu Arg Trp Asp Asn Glu Thr Asp Val Ser Gln Leu Glu Gly His 
    210                 215                 220                 


Phe Asp Ile Val Met Cys Ala Asp Cys Leu Phe Leu Asp Gln Tyr Arg 
225                 230                 235                 240 


Ala Ser Leu Val Asp Ala Ile Lys Arg Leu Leu Gln Pro Arg Gly Lys 
                245                 250                 255     


Ala Met Val Phe Ala Pro Arg Arg Gly Asn Thr Leu Asn Gln Phe Cys 
            260                 265                 270         


Asn Leu Ala Glu Lys Ala Gly Phe Cys Ile Gln Arg His Glu Asn Tyr 
        275                 280                 285             


Asp Glu His Ile Ser Asn Phe His Ser Lys Leu Lys Lys Glu Asn Pro 
    290                 295                 300                 


Asp Ile Tyr Glu Glu Asn Leu His Tyr Pro Leu Leu Leu Ile Leu Thr 
305                 310                 315                 320 


Lys His Gly 
            


<210>  5080
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  5080

Met Leu Ser Asp Asp His Val Asn Glu Ile Ile Ile Gln Val Glu Asn 
1               5                   10                  15      


Val Ser Ser Gly Val Gln Ser His Pro Ser Ser Asn Gln Ile Phe Gln 
            20                  25                  30          


Glu Lys Val Leu Leu Asp Ser Ser Ile Asn Met Val Leu Ser Ile Ser 
        35                  40                  45              


Asp Ile Asp Val Ile Asp Ser Gln Thr Val Ser Lys Arg Asn Asp Gln 
    50                  55                  60                  


Lys Gly Asn Gln Val Leu Arg Phe Ser Thr Ser Leu Asn Glu Ser Met 
65                  70                  75                  80  


Ser Gln Thr Leu His Ser Leu Glu Cys Met Gly Ile Asp Thr Pro Gly 
                85                  90                  95      


Ser Ser His Glu Thr Val Gln Gly Gln Lys Leu Ile Ala Ser Leu Ile 
            100                 105                 110         


Pro Met Thr Ser Arg Asp Arg Ile Lys Ala Ile Arg Asn Gln Pro Arg 
        115                 120                 125             


Thr Met Glu Glu Lys Arg Asn Leu Arg Lys Ile Val Asp Lys Glu Lys 
    130                 135                 140                 


Ser Lys Gln Thr His Arg Ile Leu Gln Leu Asn Cys Cys Ile Gln Cys 
145                 150                 155                 160 


Leu Asn Ser Ile Ser Arg Ala Tyr Arg Arg Ser Lys Asn Ser Leu Ser 
                165                 170                 175     


Glu Ile Leu Asn Ser Ile Ser Leu Trp Gln Lys Thr Leu Lys Ile Ile 
            180                 185                 190         


Gly Gly Lys Phe Gly Thr Ser Val Leu Ser Tyr Phe Asn Phe Leu Arg 
        195                 200                 205             


Trp Leu Leu Lys Phe Asn Ile Phe Ser Phe Ile Leu Asn Phe Ser Phe 
    210                 215                 220                 


Ile Ile Ile Pro Gln Phe Thr Val Ala Lys Lys Asn Thr Leu Gln Phe 
225                 230                 235                 240 


Thr Gly Leu Glu Phe Phe Thr Gly Val Gly Tyr Phe Arg Asp Thr Val 
                245                 250                 255     


Met Tyr Tyr Gly Phe Tyr Thr Asn Ser Thr Ile Gln His Gly Asn Ser 
            260                 265                 270         


Gly Ala Ser Tyr Asn Met Gln Leu Ala Tyr Ile Phe Thr Ile Gly Ala 
        275                 280                 285             


Cys Leu Thr Thr Cys Phe Phe Ser Leu Leu Phe Ser Met Ala Lys Tyr 
    290                 295                 300                 


Phe Arg Asn Asn Phe Ile Asn Pro His Ile Tyr Ser Gly Gly Ile Thr 
305                 310                 315                 320 


Lys Leu Ile Phe Cys Trp Asp Phe Thr Val Thr His Glu Lys Ala Val 
                325                 330                 335     


Lys Leu Lys Gln Lys Asn Leu Ser Thr Glu Ile Arg Glu Asn Leu Ser 
            340                 345                 350         


Glu Leu Arg Gln Glu Asn Ser Lys Leu Thr Phe Asn Gln Leu Leu Thr 
        355                 360                 365             


Arg Phe Ser Ala Tyr Met Val Ala Trp Val Val Ser Thr Gly Val Ala 
    370                 375                 380                 


Ile Ala Cys Cys Ala Ala Val Tyr Tyr Leu Ala Glu Tyr Asn Leu Glu 
385                 390                 395                 400 


Phe Leu Lys Thr His Ser Asn Pro Gly Ala Val Leu Leu Leu Pro Phe 
                405                 410                 415     


Val Val Ser Cys Ile Asn Leu Ala Val Pro Cys Ile Tyr Ser Met Phe 
            420                 425                 430         


Arg Leu Val Glu Arg Tyr Glu Met Pro Arg His Glu Val Tyr Val Leu 
        435                 440                 445             


Leu Ile Arg Asn Ile Phe Leu Lys Ile Ser Ile Ile Gly Ile Leu Cys 
    450                 455                 460                 


Tyr Tyr Trp Leu Asn Thr Val Ala Leu Ser Gly Glu Glu Cys Trp Glu 
465                 470                 475                 480 


Thr Leu Ile Gly Gln Asp Ile Tyr Arg Leu Leu Leu Met Asp Phe Val 
                485                 490                 495     


Phe Ser Leu Val Asn Ser Phe Leu Gly Glu Phe Leu Arg Arg Ile Ile 
            500                 505                 510         


Gly Met Gln Leu Ile Thr Ser Leu Gly Leu Gln Glu Phe Asp Ile Ala 
        515                 520                 525             


Arg Asn Val Leu Glu Leu Ile Tyr Ala Gln Thr Leu Val Trp Ile Gly 
    530                 535                 540                 


Ile Phe Phe Cys Pro Leu Leu Pro Phe Ile Gln Met Ile Met Leu Phe 
545                 550                 555                 560 


Ile Met Phe Tyr Ser Lys Asn Ile Ser Leu Met Met Asn Phe Gln Pro 
                565                 570                 575     


Pro Ser Lys Ala Trp Arg Ala Ser Gln Met Met Thr Phe Phe Ile Phe 
            580                 585                 590         


Leu Leu Phe Phe Pro Ser Phe Thr Gly Val Leu Cys Thr Leu Ala Ile 
        595                 600                 605             


Thr Ile Trp Arg Leu Lys Pro Ser Ala Asp Cys Gly Pro Phe Arg Gly 
    610                 615                 620                 


Leu Pro Leu Phe Ile His Ser Ile Tyr Ser Trp Ile Asp Thr Leu Ser 
625                 630                 635                 640 


Thr Arg Pro Gly Tyr Leu Trp Val Val Trp Ile Tyr Arg Asn Leu Ile 
                645                 650                 655     


Gly Ser Val His Phe Phe Phe Ile Leu Thr Leu Ile Val Leu Ile Ile 
            660                 665                 670         


Thr Tyr Leu Tyr Trp Gln Ile Thr Glu Gly Arg Lys Ile Met Ile Arg 
        675                 680                 685             


Leu Leu His Glu Gln Ile Ile Asn Glu Gly Lys Asp Lys Met Phe Leu 
    690                 695                 700                 


Ile Glu Lys Leu Ile Lys Leu Gln Asp Met Glu Lys Lys Ala Asn Pro 
705                 710                 715                 720 


Ser Ser Leu Val Leu Glu Arg Arg Glu Val Glu Gln Gln Gly Phe Leu 
                725                 730                 735     


His Leu Gly Glu His Asp Gly Ser Leu Asp Leu Arg Ser Arg Arg Ser 
            740                 745                 750         


Val Gln Glu Gly Asn Pro Arg Ala 
        755                 760 


<210>  5081
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  5081

Met Asp Thr Arg Ser Gly Ser Gln Cys Ser Val Thr Pro Glu Ala Ile 
1               5                   10                  15      


Leu Asn Asn Glu Lys Leu Val Leu Pro Pro Arg Ile Ser Arg Val Asn 
            20                  25                  30          


Gly Trp Ser Leu Pro Leu His Tyr Phe Gln Val Val Thr Trp Ala Val 
        35                  40                  45              


Phe Val Gly Leu Ser Ser Ala Thr Phe Gly Ile Phe Ile Pro Phe Leu 
    50                  55                  60                  


Pro His Ala Trp Lys Tyr Ile Ala Tyr Val Val Thr Gly Gly Ile Phe 
65                  70                  75                  80  


Ser Phe His Leu Val Val His Leu Ile Ala Ser Cys Ile Asp Pro Ala 
                85                  90                  95      


Asp Ser Asn Val Arg Leu Met Lys Asn Tyr Ser Gln Pro Met Pro Leu 
            100                 105                 110         


Phe Asp Arg Ser Lys His Ala His Val Ile Gln Asn Gln Phe Cys His 
        115                 120                 125             


Leu Cys Lys Val Thr Val Asn Lys Lys Thr Lys His Cys Ile Ser Cys 
    130                 135                 140                 


Asn Lys Cys Val Ser Gly Phe Asp His His Cys Lys Trp Ile Asn Asn 
145                 150                 155                 160 


Cys Val Gly Ser Arg Asn Tyr Trp Phe Phe Phe Ser Thr Val Ala Ser 
                165                 170                 175     


Ala Thr Ala Gly Met Leu Cys Leu Ile Ala Ile Leu Leu Tyr Val Leu 
            180                 185                 190         


Val Gln Tyr Leu Val Asn Pro Gly Val Leu Arg Thr Asp Pro Arg Tyr 
        195                 200                 205             


Glu Asp Val Lys Asn Met Asn Thr Trp Leu Leu Phe Leu Pro Leu Phe 
    210                 215                 220                 


Pro Val Gln Val Gln Thr Leu Ile Val Val Ile Ile Gly Met Leu Val 
225                 230                 235                 240 


Leu Leu Leu Asp Phe Leu Gly Leu Val His Leu Gly Gln Leu Leu Ile 
                245                 250                 255     


Phe His Ile Tyr Leu Lys Ala Lys Lys Met Thr Thr Phe Glu Tyr Leu 
            260                 265                 270         


Ile Asn Asn Arg Lys Glu Glu Ser Ser Lys His Gln Ala Val Arg Lys 
        275                 280                 285             


Asp Pro Tyr Val Gln Met Asp Lys Gly Val Leu Gln Gln Gly Ala Gly 
    290                 295                 300                 


Ala Leu Gly Ser Ser Ala Gln Gly Val Lys Ala Lys Ser Ser Leu Leu 
305                 310                 315                 320 


Ile His Lys His Leu Cys His Phe Cys Thr Ser Val Asn Gln Asp Gly 
                325                 330                 335     


Asp Ser Thr Ala Arg Glu Gly Asp Glu Asp Pro Cys Pro Ser Ala Leu 
            340                 345                 350         


Gly Ala Lys Ala Arg Asn Ser Arg Leu Ile Cys Arg Arg Leu Cys Gln 
        355                 360                 365             


Phe Ser Thr Arg Val His Pro Asp Gly Gly Ser Met Ala Gln Glu Ala 
    370                 375                 380                 


Asp Asp Ala Pro Ser Ile Ser Thr Leu Gly Leu Gln Gln Glu Thr Thr 
385                 390                 395                 400 


Glu Pro Met Lys Thr Asp Ser Ala Glu Ser Glu Asp 
                405                 410         


<210>  5082
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  5082

Met His Pro Phe Gln Trp Cys Asn Gly Cys Phe Cys Gly Leu Gly Leu 
1               5                   10                  15      


Val Ser Thr Asn Lys Ser Cys Ser Met Pro Pro Ile Ser Phe Gln Asp 
            20                  25                  30          


Leu Pro Leu Asn Ile Tyr Met Val Ile Phe Gly Thr Gly Ile Phe Val 
        35                  40                  45              


Phe Met Leu Ser Leu Ile Phe Cys Cys Tyr Phe Ile Ser Lys Leu Arg 
    50                  55                  60                  


Asn Gln Ala Gln Ser Glu Arg Tyr Gly Tyr Lys Glu Val Val Leu Lys 
65                  70                  75                  80  


Gly Asp Ala Lys Lys Leu Gln Leu Tyr Gly Gln Thr Cys Ala Val Cys 
                85                  90                  95      


Leu Glu Asp Phe Lys Gly Lys Asp Glu Leu Gly Val Leu Pro Cys Gln 
            100                 105                 110         


His Ala Phe His Arg Lys Cys Leu Val Lys Trp Leu Glu Val Arg Cys 
        115                 120                 125             


Val Cys Pro Met Cys Asn Lys Pro Ile Ala Ser Pro Ser Glu Ala Thr 
    130                 135                 140                 


Gln Asn Ile Gly Ile Leu Leu Asp Glu Leu Val 
145                 150                 155 


<210>  5083
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  5083

Met Leu Leu Thr Leu Ala Gly Gly Ala Leu Phe Phe Pro Gly Leu Phe 
1               5                   10                  15      


Ala Leu Cys Thr Trp Ala Leu Arg Arg Ser Gln Pro Gly Trp Ser Arg 
            20                  25                  30          


Thr Asp Cys Val Met Ile Ser Thr Arg Leu Val Ser Ser Val His Ala 
        35                  40                  45              


Val Leu Ala Thr Gly Ser Gly Ile Val Ile Ile Arg Ser Cys Asp Asp 
    50                  55                  60                  


Val Ile Thr Gly Arg His Trp Leu Ala Arg Glu Tyr Val Trp Phe Leu 
65                  70                  75                  80  


Ile Pro Tyr Met Ile Tyr Asp Ser Tyr Ala Met Tyr Leu Cys Glu Trp 
                85                  90                  95      


Cys Arg Thr Arg Asp Gln Asn Arg Ala Pro Ser Leu Thr Leu Arg Asn 
            100                 105                 110         


Phe Leu Ser Arg Asn Arg Leu Met Ile Thr His His Ala Val Ile Leu 
        115                 120                 125             


Phe Val Leu Val Pro Val Ala Gln Arg Leu Arg Gly Asp Leu Gly Asp 
    130                 135                 140                 


Phe Phe Val Gly Cys Ile Phe Thr Ala Glu Leu Ser Thr Pro Phe Val 
145                 150                 155                 160 


Ser Leu Gly Arg Val Leu Ile Gln Leu Lys Gln Gln His Thr Leu Leu 
                165                 170                 175     


Tyr Lys Val Asn Gly Ile Leu Thr Leu Ala Thr Phe Leu Ser Cys Arg 
            180                 185                 190         


Ile Leu Leu Phe Pro Phe Met Tyr Trp Ser Tyr Gly Arg Gln Gln Gly 
        195                 200                 205             


Leu Ser Leu Leu Gln Val Pro Phe Ser Ile Pro Phe Tyr Cys Asn Val 
    210                 215                 220                 


Ala Asn Ala Phe Leu Val Ala Pro Gln Ile Tyr Trp Phe Cys Leu Leu 
225                 230                 235                 240 


Cys Arg Lys Ala Val Arg Leu Phe Asp Thr Pro Gln Ala Lys Lys Asp 
                245                 250                 255     


Gly 
    


<210>  5084
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  5084

Met Pro Glu Leu Val Val Thr Ala Leu Leu Ala Pro Ser Arg Leu Ser 
1               5                   10                  15      


Leu Lys Leu Leu Arg Ala Phe Met Trp Ser Leu Val Phe Ser Val Ala 
            20                  25                  30          


Leu Val Ala Ala Ala Val Tyr Gly Cys Ile Ala Leu Thr His Val Leu 
        35                  40                  45              


Cys Arg Pro Arg Arg Gly Cys Cys Gly Arg Arg Arg Ser Ala Ser Pro 
    50                  55                  60                  


Ala Cys Leu Ser Asp Pro Ser Leu Gly Glu His Gly Phe Leu Asn Leu 
65                  70                  75                  80  


Lys Ser Ser Gly Leu Arg Leu His Tyr Val Ser Ala Gly Arg Gly Asn 
                85                  90                  95      


Gly Pro Leu Met Leu Phe Leu His Gly Phe Pro Glu Asn Trp Phe Ser 
            100                 105                 110         


Trp Arg Tyr Gln Leu Arg Glu Phe Gln Ser Arg Phe His Val Val Ala 
        115                 120                 125             


Val Asp Leu Arg Gly Tyr Gly Pro Ser Asp Ala Pro Arg Asp Val Asp 
    130                 135                 140                 


Cys Tyr Thr Ile Asp Leu Leu Leu Val Asp Ile Lys Asp Val Ile Leu 
145                 150                 155                 160 


Gly Leu Gly Tyr Ser Lys Cys Ile Leu Val Ala His Asp Trp Gly Ala 
                165                 170                 175     


Leu Leu Ala Trp His Phe Ser Ile Tyr Tyr Pro Ser Leu Val Glu Arg 
            180                 185                 190         


Met Val Val Val Ser Gly Ala Pro Met Ser Val Tyr Gln Asp Tyr Ser 
        195                 200                 205             


Leu His His Ile Ser Gln Phe Phe Arg Ser His Tyr Met Phe Leu Phe 
    210                 215                 220                 


Gln Leu Pro Trp Leu Pro Glu Lys Leu Leu Ser Met Ser Asp Phe Gln 
225                 230                 235                 240 


Ile Leu Lys Thr Thr Leu Thr His Arg Lys Thr Gly Ile Pro Cys Leu 
                245                 250                 255     


Thr Pro Ser Glu Leu Glu Ala Phe Leu Tyr Asn Phe Ser Gln Pro Gly 
            260                 265                 270         


Gly Leu Thr Gly Pro Leu Asn Tyr Tyr Arg Asn Leu Phe Arg Asn Phe 
        275                 280                 285             


Pro Leu Glu Pro Gln Glu Leu Thr Thr Pro Thr Leu Leu Leu Trp Gly 
    290                 295                 300                 


Glu Lys Asp Thr Tyr Leu Glu Leu Gly Leu Val Glu Ala Ile Gly Ser 
305                 310                 315                 320 


Arg Phe Val Pro Gly Arg Leu Glu Ala His Ile Leu Pro Gly Ile Gly 
                325                 330                 335     


His Trp Ile Pro Gln Ser Asn Pro Gln Glu Met His Gln Tyr Met Trp 
            340                 345                 350         


Ala Phe Leu Gln Asp Leu Leu Asp 
        355                 360 


<210>  5085
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  5085

Met Thr Cys Cys Glu Gly Trp Thr Ser Cys Asn Gly Phe Ser Leu Leu 
1               5                   10                  15      


Val Leu Leu Leu Leu Gly Val Val Leu Asn Ala Ile Pro Leu Ile Val 
            20                  25                  30          


Ser Leu Val Glu Glu Asp Gln Phe Ser Gln Asn Pro Ile Ser Cys Phe 
        35                  40                  45              


Glu Trp Trp Phe Pro Gly Ile Ile Gly Ala Gly Leu Met Ala Ile Pro 
    50                  55                  60                  


Ala Thr Thr Met Ser Leu Thr Ala Arg Lys Arg Ala Cys Cys Asn Asn 
65                  70                  75                  80  


Arg Thr Gly Met Phe Leu Ser Ser Leu Phe Ser Val Ile Thr Val Ile 
                85                  90                  95      


Gly Ala Leu Tyr Cys Met Leu Ile Ser Ile Gln Ala Leu Leu Lys Gly 
            100                 105                 110         


Pro Leu Met Cys Asn Ser Pro Ser Asn Ser Asn Ala Asn Cys Glu Phe 
        115                 120                 125             


Ser Leu Lys Asn Ile Ser Asp Ile His Pro Glu Ser Phe Asn Leu Gln 
    130                 135                 140                 


Trp Phe Phe Asn Asp Ser Cys Ala Pro Pro Thr Gly Phe Asn Lys Pro 
145                 150                 155                 160 


Thr Ser Asn Asp Thr Met Ala Ser Gly Trp Arg Ala Ser Ser Phe His 
                165                 170                 175     


Phe Asp Ser Glu Glu Asn Lys His Arg Leu Ile His Phe Ser Val Phe 
            180                 185                 190         


Leu Gly Leu Leu Leu Val Gly Ile Leu Glu Val Leu Phe Gly Leu Ser 
        195                 200                 205             


Gln Ile Val Ile Gly Phe Leu Gly Cys Leu Cys Gly Val Ser Lys Arg 
    210                 215                 220                 


Arg Ser Gln Ile Val 
225                 


<210>  5086
<211>  1018
<212>  PRT
<213>  Homo sapiens

<400>  5086

Met Val Ser His Phe Met Gly Ser Leu Ser Val Leu Cys Phe Leu Leu 
1               5                   10                  15      


Leu Leu Gly Phe Gln Phe Val Cys Pro Gln Pro Ser Thr Gln His Arg 
            20                  25                  30          


Lys Val Pro Gln Arg Met Ala Ala Glu Gly Ala Pro Glu Asp Asp Gly 
        35                  40                  45              


Gly Gly Gly Ala Pro Gly Val Trp Gly Ala Trp Gly Pro Trp Ser Ala 
    50                  55                  60                  


Cys Ser Arg Ser Cys Ser Gly Gly Val Met Glu Gln Thr Arg Pro Cys 
65                  70                  75                  80  


Leu Pro Arg Ser Tyr Arg Leu Arg Gly Gly Gln Arg Pro Gly Ala Pro 
                85                  90                  95      


Ala Arg Ala Phe Ala Asp His Val Val Ser Ala Val Arg Thr Ser Val 
            100                 105                 110         


Pro Leu His Arg Ser Arg Asp Glu Thr Pro Ala Leu Ala Gly Thr Asp 
        115                 120                 125             


Ala Ser Arg Gln Gly Pro Thr Val Leu Arg Gly Ser Arg His Pro Gln 
    130                 135                 140                 


Pro Gln Gly Leu Glu Val Thr Gly Asp Arg Arg Ser Arg Thr Arg Gly 
145                 150                 155                 160 


Thr Ile Gly Pro Gly Lys Tyr Gly Tyr Gly Lys Ala Pro Tyr Ile Leu 
                165                 170                 175     


Pro Leu Gln Thr Asp Thr Ala His Thr Pro Gln Arg Leu Arg Arg Gln 
            180                 185                 190         


Lys Leu Ser Ser Arg His Ser Arg Ser Gln Gly Ala Ser Ser Ala Arg 
        195                 200                 205             


His Gly Tyr Ser Ser Pro Ala His Gln Val Pro Gln His Gly Pro Leu 
    210                 215                 220                 


Tyr Gln Ser Asp Ser Gly Pro Arg Ser Gly Leu Gln Ala Ala Glu Ala 
225                 230                 235                 240 


Pro Ile Tyr Gln Leu Pro Leu Thr His Asp Gln Gly Tyr Pro Ala Ala 
                245                 250                 255     


Ser Ser Leu Phe His Ser Pro Glu Thr Ser Asn Asn His Gly Val Gly 
            260                 265                 270         


Thr His Gly Ala Thr Gln Ser Phe Ser Gln Pro Ala Arg Ser Thr Ala 
        275                 280                 285             


Ile Ser Cys Ile Gly Ala Tyr Arg Gln Tyr Lys Leu Cys Asn Thr Asn 
    290                 295                 300                 


Val Cys Pro Glu Ser Ser Arg Ser Ile Arg Glu Val Gln Cys Ala Ser 
305                 310                 315                 320 


Tyr Asn Asn Lys Pro Phe Met Gly Arg Phe Tyr Glu Trp Glu Pro Phe 
                325                 330                 335     


Ala Glu Val Lys Gly Asn Arg Lys Cys Glu Leu Asn Cys Gln Ala Met 
            340                 345                 350         


Gly Tyr Arg Phe Tyr Val Arg Gln Ala Glu Lys Val Ile Asp Gly Thr 
        355                 360                 365             


Pro Cys Asp Gln Asn Gly Thr Ala Ile Cys Val Ser Gly Gln Cys Lys 
    370                 375                 380                 


Ser Ile Gly Cys Asp Asp Tyr Leu Gly Ser Asp Lys Val Val Asp Lys 
385                 390                 395                 400 


Cys Gly Val Cys Gly Gly Asp Asn Thr Gly Cys Gln Val Val Ser Gly 
                405                 410                 415     


Val Phe Lys His Ala Leu Thr Ser Leu Gly Tyr His Arg Val Val Glu 
            420                 425                 430         


Ile Pro Glu Gly Ala Thr Lys Ile Asn Ile Thr Glu Met Tyr Lys Ser 
        435                 440                 445             


Asn Asn Tyr Leu Ala Leu Arg Ser Arg Ser Gly Arg Ser Ile Ile Asn 
    450                 455                 460                 


Gly Asn Trp Ala Ile Asp Arg Pro Gly Lys Tyr Glu Gly Gly Gly Thr 
465                 470                 475                 480 


Met Phe Thr Tyr Lys Arg Pro Asn Glu Ile Ser Ser Thr Ala Gly Glu 
                485                 490                 495     


Ser Phe Leu Ala Glu Gly Pro Thr Asn Glu Ile Leu Asp Val Tyr Met 
            500                 505                 510         


Ile His Gln Gln Pro Asn Pro Gly Val His Tyr Glu Tyr Val Ile Met 
        515                 520                 525             


Gly Thr Asn Ala Ile Ser Pro Gln Val Pro Pro His Arg Arg Pro Gly 
    530                 535                 540                 


Glu Pro Phe Asn Gly Gln Met Val Thr Glu Gly Arg Ser Gln Glu Glu 
545                 550                 555                 560 


Gly Glu Gln Lys Gly Arg Asn Glu Glu Lys Glu Asp Leu Arg Gly Glu 
                565                 570                 575     


Ala Pro Glu Met Phe Thr Ser Glu Ser Ala Gln Thr Phe Pro Val Arg 
            580                 585                 590         


His Pro Asp Arg Phe Ser Pro His Arg Pro Asp Asn Leu Val Pro Pro 
        595                 600                 605             


Ala Pro Gln Pro Pro Arg Arg Ser Arg Asp His Asn Trp Lys Gln Leu 
    610                 615                 620                 


Gly Thr Thr Glu Cys Ser Thr Thr Cys Gly Lys Gly Ser Gln Tyr Pro 
625                 630                 635                 640 


Ile Phe Arg Cys Val His Arg Ser Thr His Glu Glu Ala Pro Glu Ser 
                645                 650                 655     


Tyr Cys Asp Ser Ser Met Lys Pro Thr Pro Glu Glu Glu Pro Cys Asn 
            660                 665                 670         


Ile Phe Pro Cys Pro Ala Phe Trp Asp Ile Gly Glu Trp Ser Glu Cys 
        675                 680                 685             


Ser Lys Thr Cys Gly Leu Gly Met Gln His Arg Gln Val Leu Cys Arg 
    690                 695                 700                 


Gln Val Tyr Ala Asn Arg Ser Leu Thr Val Gln Pro Tyr Arg Cys Gln 
705                 710                 715                 720 


His Leu Glu Lys Pro Glu Thr Thr Ser Thr Cys Gln Leu Lys Ile Cys 
                725                 730                 735     


Ser Glu Trp Gln Ile Arg Thr Asp Trp Thr Ser Cys Ser Val Pro Cys 
            740                 745                 750         


Gly Val Gly Gln Arg Thr Arg Asp Val Lys Cys Val Ser Asn Ile Gly 
        755                 760                 765             


Asp Val Val Asp Asp Glu Glu Cys Asn Met Lys Leu Arg Pro Asn Asp 
    770                 775                 780                 


Ile Glu Asn Cys Asp Met Gly Pro Cys Ala Lys Ser Trp Phe Leu Thr 
785                 790                 795                 800 


Glu Trp Ser Glu Arg Cys Ser Ala Glu Cys Gly Ala Gly Val Arg Thr 
                805                 810                 815     


Arg Ser Val Val Cys Met Thr Asn His Val Ser Ser Leu Pro Leu Glu 
            820                 825                 830         


Gly Cys Gly Asn Asn Arg Pro Ala Glu Ala Thr Pro Cys Asp Asn Gly 
        835                 840                 845             


Pro Cys Thr Gly Lys Val Glu Trp Phe Ala Gly Ser Trp Ser Gln Cys 
    850                 855                 860                 


Ser Ile Glu Cys Gly Ser Gly Thr Gln Gln Arg Glu Val Ile Cys Val 
865                 870                 875                 880 


Arg Lys Asn Ala Asp Thr Phe Glu Val Leu Asp Pro Ser Glu Cys Ser 
                885                 890                 895     


Phe Leu Glu Lys Pro Pro Ser Gln Gln Ser Cys His Leu Lys Pro Cys 
            900                 905                 910         


Gly Ala Lys Trp Phe Ser Thr Glu Trp Ser Met Cys Ser Lys Ser Cys 
        915                 920                 925             


Gln Gly Gly Phe Arg Val Arg Glu Val Arg Cys Leu Ser Asp Asp Met 
    930                 935                 940                 


Thr Leu Ser Asn Leu Cys Asp Pro Gln Leu Lys Pro Glu Glu Arg Glu 
945                 950                 955                 960 


Ser Cys Asn Pro Gln Asp Cys Val Pro Glu Val Asp Glu Asn Cys Lys 
                965                 970                 975     


Asp Lys Tyr Tyr Asn Cys Asn Val Val Val Gln Ala Arg Leu Cys Val 
            980                 985                 990         


Tyr Asn Tyr Tyr Lys Thr Ala Cys  Cys Ala Ser Cys Thr  Arg Val Ala 
        995                 1000                 1005             


Asn Arg  Gln Thr Gly Phe Leu  Gly Ser Arg 
    1010                 1015             


<210>  5087
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  5087

Met Ala Glu Ser Val Glu Arg Leu Gln Gln Arg Val Gln Glu Leu Glu 
1               5                   10                  15      


Arg Glu Leu Ala Gln Glu Arg Ser Leu Gln Val Pro Arg Ser Gly Asp 
            20                  25                  30          


Gly Gly Gly Gly Arg Val Arg Ile Glu Lys Met Ser Ser Glu Val Val 
        35                  40                  45              


Asp Ser Asn Pro Tyr Ser Arg Leu Met Ala Leu Lys Arg Met Gly Ile 
    50                  55                  60                  


Val Ser Asp Tyr Glu Lys Ile Arg Thr Phe Ala Val Ala Ile Val Gly 
65                  70                  75                  80  


Val Gly Gly Val Gly Ser Val Thr Ala Glu Met Leu Thr Arg Cys Gly 
                85                  90                  95      


Ile Gly Lys Leu Leu Leu Phe Asp Tyr Asp Lys Val Glu Leu Ala Asn 
            100                 105                 110         


Met Asn Arg Leu Phe Phe Gln Pro His Gln Ala Gly Leu Ser Lys Val 
        115                 120                 125             


Gln Ala Ala Glu His Thr Leu Arg Asn Ile Asn Pro Asp Val Leu Phe 
    130                 135                 140                 


Glu Val His Asn Tyr Asn Ile Thr Thr Val Glu Asn Phe Gln His Phe 
145                 150                 155                 160 


Met Asp Arg Ile Ser Asn Gly Gly Leu Glu Glu Gly Lys Pro Val Asp 
                165                 170                 175     


Leu Val Leu Ser Cys Val Asp Asn Phe Glu Ala Arg Met Thr Ile Asn 
            180                 185                 190         


Thr Ala Cys Asn Glu Leu Gly Gln Thr Trp Met Glu Ser Gly Val Ser 
        195                 200                 205             


Glu Asn Ala Val Ser Gly His Ile Gln Leu Ile Ile Pro Gly Glu Ser 
    210                 215                 220                 


Ala Cys Phe Ala Cys Ala Pro Pro Leu Val Val Ala Ala Asn Ile Asp 
225                 230                 235                 240 


Glu Lys Thr Leu Lys Arg Glu Gly Val Cys Ala Ala Ser Leu Pro Thr 
                245                 250                 255     


Thr Met Gly Val Val Ala Gly Ile Leu Val Gln Asn Val Leu Lys Phe 
            260                 265                 270         


Leu Leu Asn Phe Gly Thr Val Ser Phe Tyr Leu Gly Tyr Asn Ala Met 
        275                 280                 285             


Gln Asp Phe Phe Pro Thr Met Ser Met Lys Pro Asn Pro Gln Cys Asp 
    290                 295                 300                 


Asp Arg Asn Cys Arg Lys Gln Gln Glu Glu Tyr Lys Lys Lys Val Ala 
305                 310                 315                 320 


Ala Leu Pro Lys Gln Glu Val Ile Gln Glu Glu Glu Glu Ile Ile His 
                325                 330                 335     


Glu Asp Asn Glu Trp Gly Ile Glu Leu Val Ser Glu Val Ser Glu Glu 
            340                 345                 350         


Glu Leu Lys Asn Phe Ser Gly Pro Val Pro Asp Leu Pro Glu Gly Ile 
        355                 360                 365             


Thr Val Ala Tyr Thr Ile Pro Lys Lys Gln Glu Asp Ser Val Thr Glu 
    370                 375                 380                 


Leu Thr Val Glu Asp Ser Gly Glu Ser Leu Glu Asp Leu Met Ala Lys 
385                 390                 395                 400 


Met Lys Asn Met 
                


<210>  5088
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  5088

Met Asp Leu Leu Gln Phe Leu Ala Phe Leu Phe Val Leu Leu Leu Ser 
1               5                   10                  15      


Gly Met Gly Ala Thr Gly Thr Leu Arg Thr Ser Leu Asp Pro Ser Leu 
            20                  25                  30          


Glu Ile Tyr Lys Lys Met Phe Glu Val Lys Arg Arg Glu Gln Leu Leu 
        35                  40                  45              


Ala Leu Lys Asn Leu Ala Gln Leu Asn Asp Ile His Gln Gln Tyr Lys 
    50                  55                  60                  


Ile Leu Asp Val Met Leu Lys Gly Leu Phe Lys Val Leu Glu Asp Ser 
65                  70                  75                  80  


Arg Thr Val Leu Thr Ala Ala Asp Val Leu Pro Asp Gly Pro Phe Pro 
                85                  90                  95      


Gln Asp Glu Lys Leu Lys Asp Ala Phe Ser His Val Val Glu Asn Thr 
            100                 105                 110         


Ala Phe Phe Gly Asp Val Val Leu Arg Phe Pro Arg Ile Val His Tyr 
        115                 120                 125             


Tyr Phe Asp His Asn Ser Asn Trp Asn Leu Leu Ile Arg Trp Gly Ile 
    130                 135                 140                 


Ser Phe Cys Asn Gln Thr Gly Val Phe Asn Gln Gly Pro His Ser Pro 
145                 150                 155                 160 


Ile Leu Ser Leu Met Ala Gln Glu Leu Gly Ile Ser Glu Lys Asp Ser 
                165                 170                 175     


Asn Phe Gln Asn Pro Phe Lys Ile Asp Arg Thr Glu Phe Ile Pro Ser 
            180                 185                 190         


Thr Asp Pro Phe Gln Lys Ala Leu Arg Glu Glu Glu Lys Arg Arg Lys 
        195                 200                 205             


Lys Glu Glu Lys Arg Lys Glu Ile Arg Lys Gly Pro Arg Ile Ser Arg 
    210                 215                 220                 


Ser Gln Ser Glu Leu 
225                 


<210>  5089
<211>  534
<212>  PRT
<213>  Homo sapiens

<400>  5089

Met Arg Leu Arg Gly Cys Gly Pro Arg Ala Ala Pro Ala Ser Ser Ala 
1               5                   10                  15      


Gly Ala Ser Asp Ala Arg Leu Leu Ala Pro Pro Gly Arg Asn Pro Phe 
            20                  25                  30          


Val His Glu Leu Arg Leu Ser Ala Leu Gln Lys Ala Gln Val Ala Leu 
        35                  40                  45              


Met Thr Leu Thr Leu Phe Pro Val Arg Leu Leu Val Ala Ala Ala Met 
    50                  55                  60                  


Met Leu Leu Ala Trp Pro Leu Ala Leu Val Ala Ser Leu Gly Ser Ala 
65                  70                  75                  80  


Glu Lys Glu Pro Glu Gln Pro Pro Ala Leu Trp Arg Lys Val Val Asp 
                85                  90                  95      


Phe Leu Leu Lys Ala Ile Met Arg Thr Met Trp Phe Ala Gly Gly Phe 
            100                 105                 110         


His Arg Val Ala Val Lys Gly Arg Gln Ala Leu Pro Thr Glu Ala Ala 
        115                 120                 125             


Ile Leu Thr Leu Ala Pro His Ser Ser Tyr Phe Asp Ala Ile Pro Val 
    130                 135                 140                 


Thr Met Thr Met Ser Ser Ile Val Met Lys Ala Glu Ser Arg Asp Ile 
145                 150                 155                 160 


Pro Ile Trp Gly Thr Leu Ile Gln Tyr Ile Arg Pro Val Phe Val Ser 
                165                 170                 175     


Arg Ser Asp Gln Asp Ser Arg Arg Lys Thr Val Glu Glu Ile Lys Arg 
            180                 185                 190         


Arg Ala Gln Ser Asn Gly Lys Trp Pro Gln Ile Met Ile Phe Pro Glu 
        195                 200                 205             


Gly Thr Cys Thr Asn Arg Thr Cys Leu Ile Thr Phe Lys Pro Gly Ala 
    210                 215                 220                 


Phe Ile Pro Gly Ala Pro Val Gln Pro Val Val Leu Arg Tyr Pro Asn 
225                 230                 235                 240 


Lys Leu Asp Thr Ile Thr Trp Thr Trp Gln Gly Pro Gly Ala Leu Glu 
                245                 250                 255     


Ile Leu Trp Leu Thr Leu Cys Gln Phe His Asn Gln Val Glu Ile Glu 
            260                 265                 270         


Phe Leu Pro Val Tyr Ser Pro Ser Glu Glu Glu Lys Arg Asn Pro Ala 
        275                 280                 285             


Leu Tyr Ala Ser Asn Val Arg Arg Val Met Ala Glu Ala Leu Gly Val 
    290                 295                 300                 


Ser Val Thr Asp Tyr Thr Phe Glu Asp Cys Gln Leu Ala Leu Ala Glu 
305                 310                 315                 320 


Gly Gln Leu Arg Leu Pro Ala Asp Thr Cys Leu Leu Glu Phe Ala Arg 
                325                 330                 335     


Leu Val Arg Gly Leu Gly Leu Lys Pro Glu Lys Leu Glu Lys Asp Leu 
            340                 345                 350         


Asp Arg Tyr Ser Glu Arg Ala Arg Met Lys Gly Gly Glu Lys Ile Gly 
        355                 360                 365             


Ile Ala Glu Phe Ala Ala Ser Leu Glu Val Pro Val Ser Asp Leu Leu 
    370                 375                 380                 


Glu Asp Met Phe Ser Leu Phe Asp Glu Ser Gly Ser Gly Glu Val Asp 
385                 390                 395                 400 


Leu Arg Glu Cys Val Val Ala Leu Ser Val Val Cys Arg Pro Ala Arg 
                405                 410                 415     


Thr Leu Asp Thr Ile Gln Leu Ala Phe Lys Met Tyr Gly Ala Gln Glu 
            420                 425                 430         


Asp Gly Ser Val Gly Glu Gly Asp Leu Ser Cys Ile Leu Lys Thr Ala 
        435                 440                 445             


Leu Gly Val Ala Glu Leu Thr Val Thr Asp Leu Phe Arg Ala Ile Asp 
    450                 455                 460                 


Gln Glu Glu Lys Gly Lys Ile Thr Phe Ala Asp Phe His Arg Phe Ala 
465                 470                 475                 480 


Glu Met Tyr Pro Ala Phe Ala Glu Glu Tyr Leu Tyr Pro Asp Gln Thr 
                485                 490                 495     


His Phe Glu Ser Cys Ala Glu Thr Ser Pro Ala Pro Ile Pro Asn Gly 
            500                 505                 510         


Phe Cys Ala Asp Phe Ser Pro Glu Asn Ser Asp Ala Gly Arg Lys Pro 
        515                 520                 525             


Val Arg Lys Lys Leu Asp 
    530                 


<210>  5090
<211>  1192
<212>  PRT
<213>  Homo sapiens

<400>  5090

Met Phe Cys Ser Glu Lys Lys Leu Arg Glu Val Glu Arg Ile Val Lys 
1               5                   10                  15      


Ala Asn Asp Arg Glu Tyr Asn Glu Lys Phe Gln Tyr Ala Asp Asn Arg 
            20                  25                  30          


Ile His Thr Ser Lys Tyr Asn Ile Leu Thr Phe Leu Pro Ile Asn Leu 
        35                  40                  45              


Phe Glu Gln Phe Gln Arg Val Ala Asn Ala Tyr Phe Leu Cys Leu Leu 
    50                  55                  60                  


Ile Leu Gln Leu Ile Pro Glu Ile Ser Ser Leu Thr Trp Phe Thr Thr 
65                  70                  75                  80  


Ile Val Pro Leu Val Leu Val Ile Thr Met Thr Ala Val Lys Asp Ala 
                85                  90                  95      


Thr Asp Asp Tyr Phe Arg His Lys Ser Asp Asn Gln Val Asn Asn Arg 
            100                 105                 110         


Gln Ser Glu Val Leu Ile Asn Ser Lys Leu Gln Asn Glu Lys Trp Met 
        115                 120                 125             


Asn Val Lys Val Gly Asp Ile Ile Lys Leu Glu Asn Asn Gln Phe Val 
    130                 135                 140                 


Ala Ala Asp Leu Leu Leu Leu Ser Ser Ser Glu Pro His Gly Leu Cys 
145                 150                 155                 160 


Tyr Val Glu Thr Ala Glu Leu Asp Gly Glu Thr Asn Leu Lys Val Arg 
                165                 170                 175     


His Ala Leu Ser Val Thr Ser Glu Leu Gly Ala Asp Ile Ser Arg Leu 
            180                 185                 190         


Ala Gly Phe Asp Gly Ile Val Val Cys Glu Val Pro Asn Asn Lys Leu 
        195                 200                 205             


Asp Lys Phe Met Gly Ile Leu Ser Trp Lys Asp Ser Lys His Ser Leu 
    210                 215                 220                 


Asn Asn Glu Lys Ile Ile Leu Arg Gly Cys Ile Leu Arg Asn Thr Ser 
225                 230                 235                 240 


Trp Cys Phe Gly Met Val Ile Phe Ala Gly Pro Asp Thr Lys Leu Met 
                245                 250                 255     


Gln Asn Ser Gly Lys Thr Lys Phe Lys Arg Thr Ser Ile Asp Arg Leu 
            260                 265                 270         


Met Asn Thr Leu Val Leu Trp Ile Phe Gly Phe Leu Ile Cys Leu Gly 
        275                 280                 285             


Ile Ile Leu Ala Ile Gly Asn Ser Ile Trp Glu Ser Gln Thr Gly Asp 
    290                 295                 300                 


Gln Phe Arg Thr Phe Leu Phe Trp Asn Glu Gly Glu Lys Ser Ser Val 
305                 310                 315                 320 


Phe Ser Gly Phe Leu Thr Phe Trp Ser Tyr Ile Ile Ile Leu Asn Thr 
                325                 330                 335     


Val Val Pro Ile Ser Leu Tyr Val Ser Val Glu Val Ile Arg Leu Gly 
            340                 345                 350         


His Ser Tyr Phe Ile Asn Trp Asp Arg Lys Met Tyr Tyr Ser Arg Lys 
        355                 360                 365             


Ala Ile Pro Ala Val Ala Arg Thr Thr Thr Leu Asn Glu Glu Leu Gly 
    370                 375                 380                 


Gln Ile Glu Tyr Ile Phe Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn 
385                 390                 395                 400 


Ile Met Thr Phe Lys Arg Cys Ser Ile Asn Gly Arg Ile Tyr Gly Glu 
                405                 410                 415     


Val His Asp Asp Leu Asp Gln Lys Thr Glu Ile Thr Gln Glu Lys Glu 
            420                 425                 430         


Pro Val Asp Phe Ser Val Lys Ser Gln Ala Asp Arg Glu Phe Gln Phe 
        435                 440                 445             


Phe Asp His His Leu Met Glu Ser Ile Lys Met Gly Asp Pro Lys Val 
    450                 455                 460                 


His Glu Phe Leu Arg Leu Leu Ala Leu Cys His Thr Val Met Ser Glu 
465                 470                 475                 480 


Glu Asn Ser Ala Gly Glu Leu Ile Tyr Gln Val Gln Ser Pro Asp Glu 
                485                 490                 495     


Gly Ala Leu Val Thr Ala Ala Arg Asn Phe Gly Phe Ile Phe Lys Ser 
            500                 505                 510         


Arg Thr Pro Glu Thr Ile Thr Ile Glu Glu Leu Gly Thr Leu Val Thr 
        515                 520                 525             


Tyr Gln Leu Leu Ala Phe Leu Asp Phe Asn Asn Thr Arg Lys Arg Met 
    530                 535                 540                 


Ser Val Ile Val Arg Asn Pro Glu Gly Gln Ile Lys Leu Tyr Ser Lys 
545                 550                 555                 560 


Gly Ala Asp Thr Ile Leu Phe Glu Lys Leu His Pro Ser Asn Glu Val 
                565                 570                 575     


Leu Leu Ser Leu Thr Ser Asp His Leu Ser Glu Phe Ala Gly Glu Gly 
            580                 585                 590         


Leu Arg Thr Leu Ala Ile Ala Tyr Arg Asp Leu Asp Asp Lys Tyr Phe 
        595                 600                 605             


Lys Glu Trp His Lys Met Leu Glu Asp Ala Asn Ala Ala Thr Glu Glu 
    610                 615                 620                 


Arg Asp Glu Arg Ile Ala Gly Leu Tyr Glu Glu Ile Glu Arg Asp Leu 
625                 630                 635                 640 


Met Leu Leu Gly Ala Thr Ala Val Glu Asp Lys Leu Gln Glu Gly Val 
                645                 650                 655     


Ile Glu Thr Val Thr Ser Leu Ser Leu Ala Asn Ile Lys Ile Trp Val 
            660                 665                 670         


Leu Thr Gly Asp Lys Gln Glu Thr Ala Ile Asn Ile Gly Tyr Ala Cys 
        675                 680                 685             


Asn Met Leu Thr Asp Asp Met Asn Asp Val Phe Val Ile Ala Gly Asn 
    690                 695                 700                 


Asn Ala Val Glu Val Arg Glu Glu Leu Arg Lys Ala Lys Gln Asn Leu 
705                 710                 715                 720 


Phe Gly Gln Asn Arg Asn Phe Ser Asn Gly His Val Val Cys Glu Lys 
                725                 730                 735     


Lys Gln Gln Leu Glu Leu Asp Ser Ile Val Glu Glu Thr Ile Thr Gly 
            740                 745                 750         


Asp Tyr Ala Leu Ile Ile Asn Gly His Ser Leu Ala His Ala Leu Glu 
        755                 760                 765             


Ser Asp Val Lys Asn Asp Leu Leu Glu Leu Ala Cys Met Cys Lys Thr 
    770                 775                 780                 


Val Ile Cys Cys Arg Val Thr Pro Leu Gln Lys Ala Gln Val Val Glu 
785                 790                 795                 800 


Leu Val Lys Lys Tyr Arg Asn Ala Val Thr Leu Ala Ile Gly Asp Gly 
                805                 810                 815     


Ala Asn Asp Val Ser Met Ile Lys Ser Ala His Ile Gly Val Gly Ile 
            820                 825                 830         


Ser Gly Gln Glu Gly Leu Gln Ala Val Leu Ala Ser Asp Tyr Ser Phe 
        835                 840                 845             


Ala Gln Phe Arg Tyr Leu Gln Arg Leu Leu Leu Val His Gly Arg Trp 
    850                 855                 860                 


Ser Tyr Phe Arg Met Cys Lys Phe Leu Cys Tyr Phe Phe Tyr Lys Asn 
865                 870                 875                 880 


Phe Ala Phe Thr Leu Val His Phe Trp Phe Gly Phe Phe Cys Gly Phe 
                885                 890                 895     


Ser Ala Gln Thr Val Tyr Asp Gln Trp Phe Ile Thr Leu Phe Asn Ile 
            900                 905                 910         


Val Tyr Thr Ser Leu Pro Val Leu Ala Met Gly Ile Phe Asp Gln Asp 
        915                 920                 925             


Val Ser Asp Gln Asn Ser Val Asp Cys Pro Gln Leu Tyr Lys Pro Gly 
    930                 935                 940                 


Gln Leu Asn Leu Leu Phe Asn Lys Arg Lys Phe Phe Ile Cys Val Leu 
945                 950                 955                 960 


His Gly Ile Tyr Thr Ser Leu Val Leu Phe Phe Ile Pro Tyr Gly Ala 
                965                 970                 975     


Phe Tyr Asn Val Ala Gly Glu Asp Gly Gln His Ile Ala Asp Tyr Gln 
            980                 985                 990         


Ser Phe Ala Val Thr Met Ala Thr  Ser Leu Val Ile Val  Val Ser Val 
        995                 1000                 1005             


Gln Ile  Ala Leu Asp Thr Ser  Tyr Trp Thr Phe Ile  Asn His Val 
    1010                 1015                 1020             


Phe Ile  Trp Gly Ser Ile Ala  Ile Tyr Phe Ser Ile  Leu Phe Thr 
    1025                 1030                 1035             


Met His  Ser Asn Gly Ile Phe  Gly Ile Phe Pro Asn  Gln Phe Pro 
    1040                 1045                 1050             


Phe Val  Gly Asn Ala Arg His  Ser Leu Thr Gln Lys  Cys Ile Trp 
    1055                 1060                 1065             


Leu Val  Ile Leu Leu Thr Thr  Val Ala Ser Val Met  Pro Val Val 
    1070                 1075                 1080             


Ala Phe  Arg Phe Leu Lys Val  Asp Leu Tyr Pro Thr  Leu Ser Asp 
    1085                 1090                 1095             


Gln Ile  Arg Arg Trp Gln Lys  Ala Gln Lys Lys Ala  Arg Pro Pro 
    1100                 1105                 1110             


Ser Ser  Arg Arg Pro Arg Thr  Arg Arg Ser Ser Ser  Arg Arg Ser 
    1115                 1120                 1125             


Gly Tyr  Ala Phe Ala His Gln  Glu Gly Tyr Gly Glu  Leu Ile Thr 
    1130                 1135                 1140             


Ser Gly  Lys Asn Met Arg Ala  Lys Asn Pro Pro Pro  Thr Ser Gly 
    1145                 1150                 1155             


Leu Glu  Lys Thr His Tyr Asn  Ser Thr Ser Trp Ile  Glu Asn Leu 
    1160                 1165                 1170             


Cys Lys  Lys Thr Thr Asp Thr  Val Ser Ser Phe Ser  Gln Asp Lys 
    1175                 1180                 1185             


Thr Val  Lys Leu 
    1190         


<210>  5091
<211>  286
<212>  PRT
<213>  Homo sapiens

<400>  5091

Met Ala Met Glu Gly Tyr Trp Arg Phe Leu Ala Leu Leu Gly Ser Ala 
1               5                   10                  15      


Leu Leu Val Gly Phe Leu Ser Val Ile Phe Ala Leu Val Trp Val Leu 
            20                  25                  30          


His Tyr Arg Glu Gly Leu Gly Trp Asp Gly Ser Ala Leu Glu Phe Asn 
        35                  40                  45              


Trp His Pro Val Leu Met Val Thr Gly Phe Val Phe Ile Gln Gly Ile 
    50                  55                  60                  


Ala Ile Ile Val Tyr Arg Leu Pro Trp Thr Trp Lys Cys Ser Lys Leu 
65                  70                  75                  80  


Leu Met Lys Ser Ile His Ala Gly Leu Asn Ala Val Ala Ala Ile Leu 
                85                  90                  95      


Ala Ile Ile Ser Val Val Ala Val Phe Glu Asn His Asn Val Asn Asn 
            100                 105                 110         


Ile Ala Asn Met Tyr Ser Leu His Ser Trp Val Gly Leu Ile Ala Val 
        115                 120                 125             


Ile Cys Tyr Leu Leu Gln Leu Leu Ser Gly Phe Ser Val Phe Leu Leu 
    130                 135                 140                 


Pro Trp Ala Pro Leu Ser Leu Arg Ala Phe Leu Met Pro Ile His Val 
145                 150                 155                 160 


Tyr Ser Gly Ile Val Ile Phe Gly Thr Val Ile Ala Thr Ala Leu Met 
                165                 170                 175     


Gly Leu Thr Glu Lys Leu Ile Phe Ser Leu Arg Asp Pro Ala Tyr Ser 
            180                 185                 190         


Thr Phe Pro Pro Glu Gly Val Phe Val Asn Thr Leu Gly Leu Leu Ile 
        195                 200                 205             


Leu Val Phe Gly Ala Leu Ile Phe Trp Ile Val Thr Arg Pro Gln Trp 
    210                 215                 220                 


Lys Arg Pro Lys Glu Pro Asn Ser Thr Ile Leu His Pro Asn Gly Gly 
225                 230                 235                 240 


Thr Glu Gln Gly Ala Arg Gly Ser Met Pro Ala Tyr Ser Gly Asn Asn 
                245                 250                 255     


Met Asp Lys Ser Asp Ser Glu Leu Asn Ser Glu Val Ala Ala Arg Lys 
            260                 265                 270         


Arg Asn Leu Ala Leu Asp Glu Ala Gly Gln Arg Ser Thr Met 
        275                 280                 285     


<210>  5092
<211>  723
<212>  PRT
<213>  Homo sapiens

<400>  5092

Met Ser Glu Ser Ser Gly Ser Ala Leu Gln Pro Gly Arg Pro Ser Arg 
1               5                   10                  15      


Gln Pro Ala Val His Pro Glu Asn Leu Ser Leu Asp Ser Ser Cys Phe 
            20                  25                  30          


Ser Ser Pro Pro Val Asn Phe Leu Gln Glu Leu Pro Ser Tyr Arg Ser 
        35                  40                  45              


Ile Ala Arg Arg Arg Thr Thr Val His Ser Arg Asp Lys Gln Ser Gly 
    50                  55                  60                  


Thr Leu Leu Lys Pro Thr Asp Ser Tyr Ser Ser Gln Leu Glu Asp Arg 
65                  70                  75                  80  


Ile Ala Glu Asn Leu Ser Ser His Ser Leu Arg Asn Tyr Ala Leu Asn 
                85                  90                  95      


Ile Ser Glu Lys Arg Arg Leu Arg Asp Ile Gln Glu Thr Gln Met Lys 
            100                 105                 110         


Tyr Leu Ser Glu Trp Asp Gln Trp Lys Arg Tyr Ser Ser Lys Ser Trp 
        115                 120                 125             


Lys Arg Phe Leu Glu Lys Ala Arg Glu Met Thr Thr His Leu Glu Leu 
    130                 135                 140                 


Trp Arg Glu Asp Ile Arg Ser Ile Glu Gly Lys Phe Gly Thr Gly Ile 
145                 150                 155                 160 


Gln Ser Tyr Phe Ser Phe Leu Arg Phe Leu Val Leu Leu Asn Leu Val 
                165                 170                 175     


Ile Phe Leu Ile Ile Phe Met Leu Val Leu Leu Pro Val Leu Leu Thr 
            180                 185                 190         


Lys Tyr Lys Ile Thr Asn Ser Ser Phe Val Leu Ile Pro Phe Lys Asp 
        195                 200                 205             


Met Asp Lys Gln Cys Thr Val Tyr Pro Val Ser Ser Ser Gly Leu Ile 
    210                 215                 220                 


Tyr Phe Tyr Ser Tyr Ile Ile Asp Leu Leu Ser Gly Thr Gly Phe Leu 
225                 230                 235                 240 


Glu Glu Thr Ser Leu Phe Tyr Gly His Tyr Thr Ile Asp Gly Val Lys 
                245                 250                 255     


Phe Gln Asn Phe Thr Tyr Asp Leu Pro Leu Ala Tyr Leu Leu Ser Thr 
            260                 265                 270         


Ile Ala Ser Leu Ala Leu Ser Leu Leu Trp Ile Val Lys Arg Ser Val 
        275                 280                 285             


Glu Gly Phe Lys Ile Asn Leu Ile Arg Ser Glu Glu His Phe Gln Ser 
    290                 295                 300                 


Tyr Cys Asn Lys Ile Phe Ala Gly Trp Asp Phe Cys Ile Thr Asn Arg 
305                 310                 315                 320 


Ser Met Ala Asp Leu Lys His Ser Ser Leu Arg Tyr Glu Leu Arg Ala 
                325                 330                 335     


Asp Leu Glu Glu Glu Arg Met Arg Gln Lys Ile Ala Glu Arg Thr Ser 
            340                 345                 350         


Glu Glu Thr Ile Arg Ile Tyr Ser Leu Arg Leu Phe Leu Asn Cys Ile 
        355                 360                 365             


Val Leu Ala Val Leu Gly Ala Cys Phe Tyr Ala Ile Tyr Val Ala Thr 
    370                 375                 380                 


Val Phe Ser Gln Glu His Met Lys Lys Glu Ile Asp Lys Met Val Phe 
385                 390                 395                 400 


Gly Glu Asn Leu Phe Ile Leu Tyr Leu Pro Ser Ile Val Ile Thr Leu 
                405                 410                 415     


Ala Asn Phe Ile Thr Pro Met Ile Phe Ala Lys Ile Ile Arg Tyr Glu 
            420                 425                 430         


Asp Tyr Ser Pro Gly Phe Glu Ile Arg Leu Thr Ile Leu Arg Cys Val 
        435                 440                 445             


Phe Met Arg Leu Ala Thr Ile Cys Val Leu Val Phe Thr Leu Gly Ser 
    450                 455                 460                 


Lys Ile Thr Ser Cys Asp Asp Asp Thr Cys Asp Leu Cys Gly Tyr Asn 
465                 470                 475                 480 


Gln Lys Leu Tyr Pro Cys Trp Glu Thr Gln Val Gly Gln Glu Met Tyr 
                485                 490                 495     


Lys Leu Met Ile Phe Asp Phe Ile Ile Ile Leu Ala Val Thr Leu Phe 
            500                 505                 510         


Val Asp Phe Pro Arg Lys Leu Leu Val Thr Tyr Cys Ser Ser Cys Lys 
        515                 520                 525             


Leu Ile Gln Cys Trp Gly Gln Gln Glu Phe Ala Ile Pro Asp Asn Val 
    530                 535                 540                 


Leu Gly Ile Val Tyr Gly Gln Thr Ile Cys Trp Ile Gly Ala Phe Phe 
545                 550                 555                 560 


Ser Pro Leu Leu Pro Ala Ile Ala Thr Leu Lys Phe Ile Ile Ile Phe 
                565                 570                 575     


Tyr Val Lys Glu Trp Ser Leu Leu Tyr Thr Cys Arg Pro Ser Pro Arg 
            580                 585                 590         


Pro Phe Arg Ala Ser Asn Ser Asn Phe Phe Phe Leu Leu Val Leu Leu 
        595                 600                 605             


Ile Gly Leu Cys Leu Ala Ile Ile Pro Leu Thr Ile Ser Ile Ser Arg 
    610                 615                 620                 


Ile Pro Ser Ser Lys Ala Cys Gly Pro Phe Thr Asn Phe Asn Thr Thr 
625                 630                 635                 640 


Trp Glu Val Ile Pro Lys Thr Val Ser Thr Phe Pro Ser Ser Leu Gln 
                645                 650                 655     


Ser Phe Ile His Gly Val Thr Ser Glu Ala Phe Ala Val Pro Phe Phe 
            660                 665                 670         


Met Ile Ile Cys Leu Ile Met Phe Tyr Phe Ile Ala Leu Ala Gly Ala 
        675                 680                 685             


His Lys Arg Val Val Ile Gln Leu Arg Glu Gln Leu Ser Leu Glu Ser 
    690                 695                 700                 


Arg Asp Lys Cys Tyr Leu Ile Gln Lys Leu Thr Glu Ala Gln Arg Asp 
705                 710                 715                 720 


Met Arg Asn 
            


<210>  5093
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  5093

Met Ala Leu Met Leu Ser Leu Val Leu Ser Leu Leu Lys Leu Gly Ser 
1               5                   10                  15      


Gly Gln Trp Gln Val Phe Gly Pro Asp Lys Pro Val Gln Ala Leu Val 
            20                  25                  30          


Gly Glu Asp Ala Ala Phe Ser Cys Phe Leu Ser Pro Lys Thr Asn Ala 
        35                  40                  45              


Glu Ala Met Glu Val Arg Phe Phe Arg Gly Gln Phe Ser Ser Val Val 
    50                  55                  60                  


His Leu Tyr Arg Asp Gly Lys Asp Gln Pro Phe Met Gln Met Pro Gln 
65                  70                  75                  80  


Tyr Gln Gly Arg Thr Lys Leu Val Lys Asp Ser Ile Ala Glu Gly Arg 
                85                  90                  95      


Ile Ser Leu Arg Leu Glu Asn Ile Thr Val Leu Asp Ala Gly Leu Tyr 
            100                 105                 110         


Gly Cys Arg Ile Ser Ser Gln Ser Tyr Tyr Gln Lys Ala Ile Trp Glu 
        115                 120                 125             


Leu Gln Val Ser Ala Leu Gly Ser Val Pro Leu Ile Ser Ile Thr Gly 
    130                 135                 140                 


Tyr Val Asp Arg Asp Ile Gln Leu Leu Cys Gln Ser Ser Gly Trp Phe 
145                 150                 155                 160 


Pro Arg Pro Thr Ala Lys Trp Lys Gly Pro Gln Gly Gln Asp Leu Ser 
                165                 170                 175     


Thr Asp Ser Arg Thr Asn Arg Asp Met His Gly Leu Phe Asp Val Glu 
            180                 185                 190         


Ile Ser Leu Thr Val Gln Glu Asn Ala Gly Ser Ile Ser Cys Ser Met 
        195                 200                 205             


Arg His Ala His Leu Ser Arg Glu Val Glu Ser Arg Val Gln Ile Gly 
    210                 215                 220                 


Asp Thr Phe Phe Glu Pro Ile Ser Trp His Leu Ala Thr Lys Val Leu 
225                 230                 235                 240 


Gly Ile Leu Cys Cys Gly Leu Phe Phe Gly Ile Val Gly Leu Lys Ile 
                245                 250                 255     


Phe Phe Ser Lys Phe Gln Cys Lys Arg Glu Arg Glu Ala Trp Ala Gly 
            260                 265                 270         


Ala Leu Phe Met Val Pro Ala Gly Thr Gly Ser Glu Met Leu Pro His 
        275                 280                 285             


Pro Ala Ala Ser Leu Leu Leu Val Leu Ala Ser Arg Gly Pro Gly Pro 
    290                 295                 300                 


Lys Lys Glu Asn Pro Gly Gly Thr Gly Leu Glu Lys Lys Ala Arg Thr 
305                 310                 315                 320 


Gly Arg Ile Glu Arg Arg Pro Glu Thr Arg Ser Gly Gly Asp Ser Gly 
                325                 330                 335     


Ser Arg Asp Gly Ser Pro Glu Ala Leu Arg Phe 
            340                 345         


<210>  5094
<211>  1049
<212>  PRT
<213>  Homo sapiens

<400>  5094

Met Glu Lys Arg Leu Gly Val Lys Pro Asn Pro Ala Ser Trp Ile Leu 
1               5                   10                  15      


Ser Gly Tyr Tyr Trp Gln Thr Ser Ala Lys Trp Leu Arg Ser Leu Tyr 
            20                  25                  30          


Leu Phe Tyr Thr Cys Phe Cys Phe Ser Val Leu Trp Leu Ser Thr Asp 
        35                  40                  45              


Ala Ser Glu Ser Arg Cys Gln Gln Gly Lys Thr Gln Phe Gly Val Gly 
    50                  55                  60                  


Leu Arg Ser Gly Gly Glu Asn His Leu Trp Leu Leu Glu Gly Thr Pro 
65                  70                  75                  80  


Ser Leu Gln Ser Cys Trp Ala Ala Cys Cys Gln Asp Ser Ala Cys His 
                85                  90                  95      


Val Phe Trp Trp Leu Glu Gly Met Cys Ile Gln Ala Asp Cys Ser Arg 
            100                 105                 110         


Pro Gln Ser Cys Arg Ala Phe Arg Thr His Ser Ser Asn Ser Met Leu 
        115                 120                 125             


Val Phe Leu Lys Lys Phe Gln Thr Ala Asp Asp Leu Gly Phe Leu Pro 
    130                 135                 140                 


Glu Asp Asp Val Pro His Leu Leu Gly Leu Gly Trp Asn Trp Ala Ser 
145                 150                 155                 160 


Trp Arg Gln Ser Pro Pro Arg Ala Ala Leu Arg Pro Ala Val Ser Ser 
                165                 170                 175     


Ser Asp Gln Gln Ser Leu Ile Arg Lys Leu Gln Lys Arg Gly Ser Pro 
            180                 185                 190         


Ser Asp Val Val Thr Pro Ile Val Thr Gln His Ser Lys Val Asn Asp 
        195                 200                 205             


Ser Asn Glu Leu Gly Gly Leu Thr Thr Ser Gly Ser Ala Glu Val His 
    210                 215                 220                 


Lys Ala Ile Thr Ile Ser Ser Pro Leu Thr Thr Asp Leu Thr Ala Glu 
225                 230                 235                 240 


Leu Ser Gly Gly Pro Lys Asn Val Ser Val Gln Pro Glu Ile Ser Glu 
                245                 250                 255     


Gly Leu Ala Thr Thr Pro Ser Thr Gln Gln Val Lys Ser Ser Glu Lys 
            260                 265                 270         


Thr Gln Ile Ala Val Pro Gln Pro Val Ala Pro Ser Tyr Ser Tyr Ala 
        275                 280                 285             


Thr Pro Thr Pro Gln Ala Ser Phe Gln Ser Thr Ser Ala Pro Tyr Pro 
    290                 295                 300                 


Val Ile Lys Glu Leu Val Val Ser Ala Gly Glu Ser Val Gln Ile Thr 
305                 310                 315                 320 


Leu Pro Lys Asn Glu Val Gln Leu Asn Ala Tyr Val Leu Gln Glu Pro 
                325                 330                 335     


Pro Lys Gly Glu Thr Tyr Thr Tyr Asp Trp Gln Leu Ile Thr His Pro 
            340                 345                 350         


Arg Asp Tyr Ser Gly Glu Met Glu Gly Lys His Ser Gln Ile Leu Lys 
        355                 360                 365             


Leu Ser Lys Leu Thr Pro Gly Leu Tyr Glu Phe Lys Val Ile Val Glu 
    370                 375                 380                 


Gly Gln Asn Ala His Gly Glu Gly Tyr Val Asn Val Thr Val Lys Pro 
385                 390                 395                 400 


Glu Pro Arg Lys Asn Arg Pro Pro Ile Ala Ile Val Ser Pro Gln Phe 
                405                 410                 415     


Gln Glu Ile Ser Leu Pro Thr Thr Ser Thr Val Ile Asp Gly Ser Gln 
            420                 425                 430         


Ser Thr Asp Asp Asp Lys Ile Val Gln Tyr His Trp Glu Glu Leu Lys 
        435                 440                 445             


Gly Pro Leu Arg Glu Glu Lys Ile Ser Glu Asp Thr Ala Ile Leu Lys 
    450                 455                 460                 


Leu Ser Lys Leu Val Pro Gly Asn Tyr Thr Phe Ser Leu Thr Val Val 
465                 470                 475                 480 


Asp Ser Asp Gly Ala Thr Asn Ser Thr Thr Ala Asn Leu Thr Val Asn 
                485                 490                 495     


Lys Ala Val Asp Tyr Pro Pro Val Ala Asn Ala Gly Pro Asn Gln Val 
            500                 505                 510         


Ile Thr Leu Pro Gln Asn Ser Ile Thr Leu Phe Gly Asn Gln Ser Thr 
        515                 520                 525             


Asp Asp His Gly Ile Thr Ser Tyr Glu Trp Ser Leu Ser Pro Ser Ser 
    530                 535                 540                 


Lys Gly Lys Val Val Glu Met Gln Gly Val Arg Thr Pro Thr Leu Gln 
545                 550                 555                 560 


Leu Ser Ala Met Gln Glu Gly Asp Tyr Thr Tyr Gln Leu Thr Val Thr 
                565                 570                 575     


Asp Thr Ile Gly Gln Gln Ala Thr Ala Gln Val Thr Val Ile Val Gln 
            580                 585                 590         


Pro Glu Asn Asn Lys Pro Pro Gln Ala Asp Ala Gly Pro Asp Lys Glu 
        595                 600                 605             


Leu Thr Leu Pro Val Asp Ser Thr Thr Leu Asp Gly Ser Lys Ser Ser 
    610                 615                 620                 


Asp Asp Gln Lys Ile Ile Ser Tyr Leu Trp Glu Lys Thr Gln Gly Pro 
625                 630                 635                 640 


Asp Gly Val Gln Leu Glu Asn Ala Asn Ser Ser Val Ala Thr Val Thr 
                645                 650                 655     


Gly Leu Gln Val Gly Thr Tyr Val Phe Thr Leu Thr Val Lys Asp Glu 
            660                 665                 670         


Arg Asn Leu Gln Ser Gln Ser Ser Val Asn Val Ile Val Lys Glu Glu 
        675                 680                 685             


Ile Asn Lys Pro Pro Ile Ala Lys Ile Thr Gly Asn Val Val Ile Thr 
    690                 695                 700                 


Leu Pro Thr Ser Thr Ala Glu Leu Asp Gly Ser Lys Ser Ser Asp Asp 
705                 710                 715                 720 


Lys Gly Ile Val Ser Tyr Leu Trp Thr Arg Asp Glu Gly Ser Pro Ala 
                725                 730                 735     


Ala Gly Glu Val Leu Asn His Ser Asp His His Pro Ile Leu Phe Leu 
            740                 745                 750         


Ser Asn Leu Val Glu Gly Thr Tyr Thr Phe His Leu Lys Val Thr Asp 
        755                 760                 765             


Ala Lys Gly Glu Ser Asp Thr Asp Arg Thr Thr Val Glu Val Lys Pro 
    770                 775                 780                 


Asp Pro Arg Lys Asn Asn Leu Val Glu Ile Ile Leu Asp Ile Asn Val 
785                 790                 795                 800 


Ser Gln Leu Thr Glu Arg Leu Lys Gly Met Phe Ile Arg Gln Ile Gly 
                805                 810                 815     


Val Leu Leu Gly Val Leu Asp Ser Asp Ile Ile Val Gln Lys Ile Gln 
            820                 825                 830         


Pro Tyr Thr Glu Gln Ser Thr Lys Met Val Phe Phe Val Gln Asn Glu 
        835                 840                 845             


Pro Pro His Gln Ile Phe Lys Gly His Glu Val Ala Ala Met Leu Lys 
    850                 855                 860                 


Ser Glu Leu Arg Lys Gln Lys Ala Asp Phe Leu Ile Phe Arg Ala Leu 
865                 870                 875                 880 


Glu Val Asn Thr Val Thr Cys Gln Leu Asn Cys Ser Asp His Gly His 
                885                 890                 895     


Cys Asp Ser Phe Thr Lys Arg Cys Ile Cys Asp Pro Phe Trp Met Glu 
            900                 905                 910         


Asn Phe Ile Lys Val Gln Leu Arg Asp Gly Asp Ser Asn Cys Glu Trp 
        915                 920                 925             


Ser Val Leu Tyr Val Ile Ile Ala Thr Phe Val Ile Val Val Ala Leu 
    930                 935                 940                 


Gly Ile Leu Ser Trp Thr Val Ile Cys Cys Cys Lys Arg Gln Lys Gly 
945                 950                 955                 960 


Lys Pro Lys Arg Lys Ser Lys Tyr Lys Ile Leu Asp Ala Thr Asp Gln 
                965                 970                 975     


Glu Ser Leu Glu Leu Lys Pro Thr Ser Arg Ala Gly Ile Lys Gln Lys 
            980                 985                 990         


Gly Leu Leu Leu Ser Ser Ser Leu  Met His Ser Glu Ser  Glu Leu Asp 
        995                 1000                 1005             


Ser Asp  Asp Ala Ile Phe Thr  Trp Pro Asp Arg Glu  Lys Gly Lys 
    1010                 1015                 1020             


Leu Leu  His Gly Gln Asn Gly  Ser Val Pro Asn Gly  Gln Thr Pro 
    1025                 1030                 1035             


Leu Lys  Ala Arg Ser Pro Arg  Glu Glu Ile Leu 
    1040                 1045                 


<210>  5095
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  5095

Met Ala Ala Ala Ala Val Gly Ala Gly His Gly Ala Gly Gly Pro Gly 
1               5                   10                  15      


Ala Ala Ser Ser Ser Gly Gly Ala Arg Glu Gly Ala Arg Val Ala Ala 
            20                  25                  30          


Leu Cys Leu Leu Trp Tyr Ala Leu Ser Ala Gly Gly Asn Val Val Asn 
        35                  40                  45              


Lys Val Ile Leu Ser Ala Phe Pro Phe Pro Val Thr Val Ser Leu Cys 
    50                  55                  60                  


His Ile Leu Ala Leu Cys Ala Gly Leu Pro Pro Leu Leu Arg Ala Trp 
65                  70                  75                  80  


Arg Val Pro Pro Ala Pro Pro Val Ser Gly Pro Gly Pro Ser Pro His 
                85                  90                  95      


Pro Ser Ser Gly Pro Leu Leu Pro Pro Arg Phe Tyr Pro Arg Tyr Val 
            100                 105                 110         


Leu Pro Leu Ala Phe Gly Lys Tyr Phe Ala Ser Val Ser Ala His Val 
        115                 120                 125             


Ser Ile Trp Lys Val Pro Val Ser Tyr Ala His Thr Val Lys Ala Thr 
    130                 135                 140                 


Met Pro Ile Trp Val Val Leu Leu Ser Arg Ile Ile Met Lys Glu Lys 
145                 150                 155                 160 


Gln Ser Thr Lys Val Tyr Leu Ser Leu Ile Pro Ile Ile Ser Gly Val 
                165                 170                 175     


Leu Leu Ala Thr Val Thr Glu Leu Ser Phe Asp Met Trp Gly Leu Val 
            180                 185                 190         


Ser Ala Leu Ala Ala Thr Leu Cys Phe Ser Leu Gln Asn Ile Phe Ser 
        195                 200                 205             


Lys Lys Val Leu Arg Asp Ser Arg Ile His His Leu Arg Leu Leu Asn 
    210                 215                 220                 


Ile Leu Gly Cys His Ala Val Phe Phe Met Ile Pro Thr Trp Val Leu 
225                 230                 235                 240 


Val Asp Leu Ser Ala Phe Leu Val Ser Ser Asp Leu Thr Tyr Val Tyr 
                245                 250                 255     


Gln Trp Pro Trp Thr Leu Leu Leu Leu Ala Val Ser Gly Phe Cys Asn 
            260                 265                 270         


Phe Ala Gln Asn Val Ile Ala Phe Ser Ile Leu Asn Leu Val Ser Pro 
        275                 280                 285             


Leu Ser Tyr Ser Val Ala Asn Ala Thr Lys Arg Ile Met Val Ile Thr 
    290                 295                 300                 


Val Ser Leu Ile Met Leu Arg Asn Pro Val Thr Ser Thr Asn Val Leu 
305                 310                 315                 320 


Gly Met Met Thr Ala Ile Leu Gly Val Phe Leu Tyr Asn Lys Thr Lys 
                325                 330                 335     


Tyr Asp Ala Asn Gln Gln Ala Arg Lys His Leu Leu Pro Val Thr Thr 
            340                 345                 350         


Ala Asp Leu Ser Ser Lys Glu Arg His Arg Ser Pro Leu Glu Lys Pro 
        355                 360                 365             


His Asn Gly Leu Leu Phe Pro Gln His Gly Asp Tyr Gln Tyr Gly Arg 
    370                 375                 380                 


Asn Asn Ile Leu Thr Asp His Phe Gln Tyr Ser Arg Gln Ser Tyr Pro 
385                 390                 395                 400 


Asn Ser Tyr Ser Leu Asn Arg Tyr Asp Val 
                405                 410 


<210>  5096
<211>  746
<212>  PRT
<213>  Homo sapiens

<400>  5096

Met Ile Ser Thr Lys Glu Lys Asn Lys Ile Pro Lys Asp Ser Met Thr 
1               5                   10                  15      


Leu Leu Pro Cys Phe Tyr Phe Val Glu Leu Pro Ile Val Ala Ser Ser 
            20                  25                  30          


Ile Val Ser Leu Tyr Phe Leu Glu Leu Thr Asp Leu Phe Lys Pro Ala 
        35                  40                  45              


Lys Val Gly Phe Gln Cys Tyr Asp Arg Thr Leu Ser Met Pro Tyr Val 
    50                  55                  60                  


Glu Thr Asn Glu Glu Leu Ile Pro Leu Leu Met Leu Leu Ser Leu Ala 
65                  70                  75                  80  


Phe Ala Ala Pro Ala Ala Ser Ile Met Val Ala Glu Gly Met Leu Tyr 
                85                  90                  95      


Cys Leu Gln Ser Arg Leu Trp Gly Arg Ala Gly Gly Pro Ala Gly Ala 
            100                 105                 110         


Glu Gly Ser Ile Asn Ala Gly Gly Cys Asn Phe Asn Ser Phe Leu Arg 
        115                 120                 125             


Arg Thr Val Arg Phe Val Gly Val His Val Phe Gly Leu Cys Ala Thr 
    130                 135                 140                 


Ala Leu Val Thr Asp Val Ile Gln Leu Ala Thr Gly Tyr His Thr Pro 
145                 150                 155                 160 


Phe Phe Leu Thr Val Cys Lys Pro Asn Tyr Thr Leu Leu Gly Thr Ser 
                165                 170                 175     


Cys Glu Val Asn Pro Tyr Ile Thr Gln Asp Ile Cys Ser Gly His Asp 
            180                 185                 190         


Ile His Ala Ile Leu Ser Ala Arg Lys Thr Phe Pro Ser Gln His Ala 
        195                 200                 205             


Thr Leu Ser Ala Phe Ala Ala Val Tyr Val Ser Val Ser Pro Ala Pro 
    210                 215                 220                 


His Cys Pro Ser Gln Ala Leu Leu Leu Thr Arg Gly Glu Pro Ser Leu 
225                 230                 235                 240 


Thr Pro Thr Pro Met Pro Gln Met Tyr Phe Asn Ser Val Ile Ser Asp 
                245                 250                 255     


Thr Thr Lys Leu Leu Lys Pro Ile Leu Val Phe Ala Phe Ala Ile Ala 
            260                 265                 270         


Ala Gly Val Cys Gly Leu Thr Gln Ile Thr Gln Tyr Arg Ser His Pro 
        275                 280                 285             


Val Asp Val Tyr Ala Gly Phe Leu Ile Gly Ala Gly Ile Ala Ala Tyr 
    290                 295                 300                 


Leu Ala Cys His Ala Val Gly Asn Phe Gln Ala Pro Pro Ala Glu Lys 
305                 310                 315                 320 


Pro Ala Ala Pro Ala Pro Ala Lys Asp Ala Leu Arg Ala Leu Thr Gln 
                325                 330                 335     


Arg Gly His Asp Ser Val Tyr Gln Gln Asn Lys Ser Val Ser Thr Asp 
            340                 345                 350         


Glu Leu Gly Pro Pro Gly Arg Leu Glu Gly Ala Pro Arg Pro Val Ala 
        355                 360                 365             


Arg Glu Lys Thr Ser Leu Gly Ser Leu Lys Arg Ala Ser Val Asp Val 
    370                 375                 380                 


Asp Leu Leu Ala Pro Arg Ser Pro Met Ala Lys Glu Asn Met Val Thr 
385                 390                 395                 400 


Phe Ser His Thr Leu Pro Arg Ala Ser Ala Pro Ser Leu Asp Asp Pro 
                405                 410                 415     


Ala Arg Arg His Met Thr Ile His Val Pro Leu Asp Ala Ser Arg Ser 
            420                 425                 430         


Lys Gln Leu Ile Ser Glu Trp Lys Gln Lys Ser Leu Glu Gly Arg Gly 
        435                 440                 445             


Leu Gly Leu Pro Asp Asp Ala Ser Pro Gly His Leu Arg Ala Pro Ala 
    450                 455                 460                 


Glu Pro Met Ala Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu 
465                 470                 475                 480 


Glu Glu Glu Glu Glu Glu Glu Asp Glu Gly Pro Ala Pro Pro Ser Leu 
                485                 490                 495     


Tyr Pro Thr Val Gln Ala Arg Pro Gly Leu Gly Pro Arg Val Ile Leu 
            500                 505                 510         


Pro Pro Arg Ala Gly Pro Pro Pro Leu Val His Ile Pro Glu Glu Gly 
        515                 520                 525             


Ala Gln Thr Gly Ala Gly Leu Ser Pro Lys Ser Gly Ala Gly Val Arg 
    530                 535                 540                 


Ala Lys Trp Leu Met Met Ala Glu Lys Ser Gly Ala Ala Val Ala Asn 
545                 550                 555                 560 


Pro Pro Arg Leu Leu Gln Val Ile Ala Met Ser Lys Ala Pro Gly Ala 
                565                 570                 575     


Pro Gly Pro Lys Ala Ala Glu Thr Ala Ser Ser Ser Ser Ala Ser Ser 
            580                 585                 590         


Asp Ser Ser Gln Tyr Arg Ser Pro Ser Asp Arg Asp Ser Ala Ser Ile 
        595                 600                 605             


Val Thr Ile Asp Ala His Ala Pro His His Pro Val Val His Leu Ser 
    610                 615                 620                 


Ala Gly Gly Ala Pro Trp Glu Trp Lys Ala Ala Gly Gly Gly Ala Lys 
625                 630                 635                 640 


Ala Glu Ala Asp Gly Gly Tyr Glu Leu Gly Asp Leu Ala Arg Gly Phe 
                645                 650                 655     


Arg Gly Gly Ala Lys Pro Pro Gly Val Ser Pro Gly Ser Ser Val Ser 
            660                 665                 670         


Asp Val Asp Gln Glu Glu Pro Arg Phe Gly Ala Val Ala Thr Val Asn 
        675                 680                 685             


Leu Ala Thr Gly Glu Gly Leu Pro Pro Leu Gly Ala Ala Asp Gly Ala 
    690                 695                 700                 


Leu Gly Pro Gly Ser Arg Glu Ser Thr Leu Arg Arg His Ala Gly Gly 
705                 710                 715                 720 


Leu Gly Leu Ala Glu Arg Glu Ala Glu Ala Glu Ala Glu Gly Tyr Phe 
                725                 730                 735     


Arg Lys Met Gln Ala Arg Arg Phe Pro Asp 
            740                 745     


<210>  5097
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  5097

Met Asp Gly Ile Ile Glu Gln Lys Ser Met Leu Val His Ser Lys Ile 
1               5                   10                  15      


Ser Asp Ala Gly Lys Arg Asn Gly Leu Ile Asn Thr Arg Asn Leu Met 
            20                  25                  30          


Ala Glu Ser Arg Asp Gly Leu Val Ser Val Tyr Pro Ala Pro Gln Tyr 
        35                  40                  45              


Gln Ser His Arg Val Gly Ala Ser Thr Val Pro Ala Ser Leu Asp Ser 
    50                  55                  60                  


Ser Arg Ser Glu Pro Met Gln Gln Leu Leu Asp Pro Asn Thr Leu Gln 
65                  70                  75                  80  


Gln Ser Val Glu Ser Arg Tyr Arg Pro Asn Ile Ile Leu Tyr Ser Glu 
                85                  90                  95      


Gly Val Leu Arg Ser Trp Gly Asp Gly Val Ala Ala Asp Cys Cys Glu 
            100                 105                 110         


Thr Thr Phe Ile Glu Asp Arg Ser Pro Thr Lys Asp Ser Leu Glu Tyr 
        115                 120                 125             


Pro Asp Gly Lys Phe Ile Asp Leu Ser Ala Asp Asp Ile Lys Ile His 
    130                 135                 140                 


Thr Leu Ser Tyr Asp Val Glu Glu Glu Glu Glu Phe Gln Glu Leu Glu 
145                 150                 155                 160 


Ser Asp Tyr Ser Ser Asp Thr Glu Ser Glu Asp Asn Phe Leu Met Met 
                165                 170                 175     


Pro Pro Arg Asp His Leu Gly Leu Ser Val Phe Ser Met Leu Cys Cys 
            180                 185                 190         


Phe Trp Pro Leu Gly Ile Ala Ala Phe Tyr Leu Ser His Glu Thr Asn 
        195                 200                 205             


Lys Ala Val Ala Lys Gly Asp Leu His Gln Ala Ser Thr Ser Ser Arg 
    210                 215                 220                 


Arg Ala Leu Phe Leu Ala Val Leu Ser Ile Thr Ile Gly Thr Gly Val 
225                 230                 235                 240 


Tyr Val Gly Val Ala Val Ala Leu Ile Ala Tyr Leu Ser Lys Asn Asn 
                245                 250                 255     


His Leu 
        


<210>  5098
<211>  904
<212>  PRT
<213>  Homo sapiens

<400>  5098

Met Glu Trp Gly Ser Glu Ser Ala Ala Val Arg Arg His Arg Val Gly 
1               5                   10                  15      


Val Glu Arg Arg Glu Gly Ala Ala Ala Ala Pro Pro Pro Glu Arg Glu 
            20                  25                  30          


Ala Arg Ala Gln Glu Pro Leu Val Asp Gly Cys Ser Gly Gly Gly Arg 
        35                  40                  45              


Thr Arg Lys Arg Ser Pro Gly Gly Ser Gly Gly Ala Ser Arg Gly Ala 
    50                  55                  60                  


Gly Thr Gly Leu Ser Glu Val Arg Ala Ala Leu Gly Leu Ala Leu Tyr 
65                  70                  75                  80  


Leu Ile Ala Leu Arg Thr Leu Val Gln Leu Ser Leu Gln Gln Leu Val 
                85                  90                  95      


Leu Arg Gly Ala Ala Gly His Arg Gly Glu Phe Asp Ala Leu Gln Ala 
            100                 105                 110         


Arg Asp Tyr Leu Glu His Ile Thr Ser Ile Gly Pro Arg Thr Thr Gly 
        115                 120                 125             


Ser Pro Glu Asn Glu Ile Leu Thr Val His Tyr Leu Leu Glu Gln Ile 
    130                 135                 140                 


Lys Leu Ile Glu Val Gln Ser Asn Ser Leu His Lys Ile Ser Val Asp 
145                 150                 155                 160 


Val Gln Arg Pro Thr Gly Ser Phe Ser Ile Asp Phe Leu Gly Gly Phe 
                165                 170                 175     


Thr Ser Tyr Tyr Asp Asn Ile Thr Asn Val Val Val Lys Leu Glu Pro 
            180                 185                 190         


Arg Asp Gly Ala Gln His Ala Val Leu Ala Asn Cys His Phe Asp Ser 
        195                 200                 205             


Val Ala Asn Ser Pro Gly Ala Ser Asp Asp Ala Val Ser Cys Ser Val 
    210                 215                 220                 


Met Leu Glu Val Leu Arg Val Leu Ser Thr Ser Ser Glu Ala Leu His 
225                 230                 235                 240 


His Ala Val Ile Phe Leu Phe Asn Gly Ala Glu Glu Asn Val Leu Gln 
                245                 250                 255     


Ala Ser His Gly Phe Ile Thr Gln His Pro Trp Ala Ser Leu Ile Arg 
            260                 265                 270         


Ala Phe Ile Asn Leu Glu Ala Ala Gly Val Gly Gly Lys Glu Leu Val 
        275                 280                 285             


Phe Gln Thr Gly Pro Glu Asn Pro Trp Leu Val Gln Ala Tyr Val Ser 
    290                 295                 300                 


Ala Ala Lys His Pro Phe Ala Ser Val Val Ala Gln Glu Val Phe Gln 
305                 310                 315                 320 


Ser Gly Ile Ile Pro Ser Asp Thr Asp Phe Arg Ile Tyr Arg Asp Phe 
                325                 330                 335     


Gly Asn Ile Pro Gly Ile Asp Leu Ala Phe Ile Glu Asn Gly Tyr Ile 
            340                 345                 350         


Tyr His Thr Lys Tyr Asp Thr Ala Asp Arg Ile Leu Thr Asp Ser Ile 
        355                 360                 365             


Gln Arg Ala Gly Asp Asn Ile Leu Ala Val Leu Lys His Leu Ala Thr 
    370                 375                 380                 


Ser Asp Met Leu Ala Ala Ala Ser Lys Tyr Arg His Gly Asn Met Val 
385                 390                 395                 400 


Phe Phe Asp Val Leu Gly Leu Phe Val Ile Ala Tyr Pro Ser Arg Ile 
                405                 410                 415     


Gly Ser Ile Ile Asn Tyr Met Val Val Met Gly Val Val Leu Tyr Leu 
            420                 425                 430         


Gly Lys Lys Phe Leu Gln Pro Lys His Lys Thr Gly Asn Tyr Lys Lys 
        435                 440                 445             


Asp Phe Leu Cys Gly Leu Gly Ile Thr Leu Ile Ser Trp Phe Thr Ser 
    450                 455                 460                 


Leu Val Thr Val Leu Ile Ile Ala Val Phe Ile Ser Leu Ile Gly Gln 
465                 470                 475                 480 


Ser Leu Ser Trp Tyr Asn His Phe Tyr Val Ser Val Cys Leu Tyr Gly 
                485                 490                 495     


Thr Ala Thr Val Ala Lys Ile Ile Leu Ile His Thr Leu Ala Lys Arg 
            500                 505                 510         


Phe Tyr Tyr Met Asn Ala Ser Ala Gln Tyr Leu Gly Glu Val Phe Phe 
        515                 520                 525             


Asp Ile Ser Leu Phe Val His Cys Cys Phe Leu Val Thr Leu Thr Tyr 
    530                 535                 540                 


Gln Gly Leu Cys Ser Ala Phe Ile Ser Ala Val Trp Val Ala Phe Pro 
545                 550                 555                 560 


Leu Leu Thr Lys Leu Cys Val His Lys Asp Phe Lys Gln His Gly Ala 
                565                 570                 575     


Gln Gly Lys Phe Ile Ala Phe Tyr Leu Leu Gly Met Phe Ile Pro Tyr 
            580                 585                 590         


Leu Tyr Ala Leu Tyr Leu Ile Trp Ala Val Phe Glu Met Phe Thr Pro 
        595                 600                 605             


Ile Leu Gly Arg Ser Gly Ser Glu Ile Pro Pro Asp Val Val Leu Ala 
    610                 615                 620                 


Ser Ile Leu Ala Gly Cys Thr Met Ile Leu Ser Ser Tyr Phe Ile Asn 
625                 630                 635                 640 


Phe Ile Tyr Leu Ala Lys Ser Thr Lys Lys Thr Met Leu Thr Leu Thr 
                645                 650                 655     


Leu Val Cys Ala Ile Thr Phe Leu Leu Val Cys Ser Gly Thr Phe Phe 
            660                 665                 670         


Pro Tyr Ser Ser Asn Pro Ala Asn Pro Lys Pro Lys Arg Val Phe Leu 
        675                 680                 685             


Gln His Met Thr Arg Thr Phe His Asp Leu Glu Gly Asn Ala Val Lys 
    690                 695                 700                 


Arg Asp Ser Gly Ile Trp Ile Asn Gly Phe Asp Tyr Thr Gly Ile Ser 
705                 710                 715                 720 


His Ile Thr Pro His Ile Pro Glu Ile Asn Asp Ser Ile Arg Ala His 
                725                 730                 735     


Cys Glu Glu Asn Ala Pro Leu Cys Gly Phe Pro Trp Tyr Leu Pro Val 
            740                 745                 750         


His Phe Leu Ile Arg Lys Asn Trp Tyr Leu Pro Ala Pro Glu Val Ser 
        755                 760                 765             


Pro Arg Asn Pro Pro His Phe Arg Leu Ile Ser Lys Glu Gln Thr Pro 
    770                 775                 780                 


Trp Asp Ser Ile Lys Leu Thr Phe Glu Ala Thr Gly Pro Ser His Met 
785                 790                 795                 800 


Ser Phe Tyr Val Arg Ala His Lys Gly Ser Thr Leu Ser Gln Trp Ser 
                805                 810                 815     


Leu Gly Asn Gly Thr Pro Val Thr Ser Lys Gly Gly Asp Tyr Phe Val 
            820                 825                 830         


Phe Tyr Ser His Gly Leu Gln Ala Ser Ala Trp Gln Phe Trp Ile Glu 
        835                 840                 845             


Val Gln Val Ser Glu Glu His Pro Glu Gly Met Val Thr Val Ala Ile 
    850                 855                 860                 


Ala Ala His Tyr Leu Ser Gly Glu Asp Lys Arg Ser Pro Gln Leu Asp 
865                 870                 875                 880 


Ala Leu Lys Glu Lys Phe Pro Asp Trp Thr Phe Pro Ser Ala Trp Val 
                885                 890                 895     


Cys Thr Tyr Asp Leu Phe Val Phe 
            900                 


<210>  5099
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  5099

Met Ser Pro Arg Met Arg His Ile Cys Tyr Phe Leu Asp Tyr Gly Ala 
1               5                   10                  15      


Leu Ser Leu Tyr Ser Leu Gly Cys Ala Phe Pro Tyr Ala Ala Tyr Ser 
            20                  25                  30          


Met Pro Ala Ser Trp Leu His Gly His Leu His Gln Phe Phe Val Pro 
        35                  40                  45              


Ala Ala Ala Leu Asn Ser Phe Leu Cys Thr Gly Leu Ser Cys Tyr Ser 
    50                  55                  60                  


Arg Phe Leu Glu Leu Glu Ser Pro Gly Leu Ser Lys Val Leu Arg Thr 
65                  70                  75                  80  


Gly Ala Phe Ala Tyr Pro Phe Leu Phe Asp Asn Leu Pro Leu Phe Tyr 
                85                  90                  95      


Arg Leu Gly Leu Cys Trp Gly Arg Gly His Gly Cys Gly Gln Glu Ala 
            100                 105                 110         


Leu Ser Thr Ser His Gly Tyr His Leu Phe Cys Ala Leu Leu Thr Gly 
        115                 120                 125             


Phe Leu Phe Ala Ser His Leu Pro Glu Arg Leu Ala Pro Gly Arg Phe 
    130                 135                 140                 


Asp Tyr Ile Gly Glu Gly Thr Pro Gly Pro Ala Arg Glu Glu Ala Gly 
145                 150                 155                 160 


Ala Asp Ala Phe Pro Glu His Arg Met Asn Trp Ala Thr Ala Thr Ser 
                165                 170                 175     


Tyr Ser Thr Ser Val Gln Cys Trp Ala Pro Thr Ser Ser Trp Arg Gln 
            180                 185                 190         


Cys Trp Leu Ile Trp Asp His Ala Glu Pro Gly Trp Pro His Arg Asn 
        195                 200                 205             


Leu Pro Trp Ala Trp Gln Ala Gln Trp Pro His Trp Ser Trp Leu Gln 
    210                 215                 220                 


Leu Gly Thr Tyr Ser Leu Leu Leu Leu Ser Gln Pro Pro Cys Phe Gly 
225                 230                 235                 240 


Pro Pro Val His Ala Leu Cys Cys Arg Val Ala His Trp Arg Gly Val 
                245                 250                 255     


Pro Arg Pro Asn Asn Ser Glu Ala Pro Ser Leu Thr Leu Ser Trp Arg 
            260                 265                 270         


Gly Gln Arg Pro Gly Pro Ser Ala Asp Glu Glu Pro Arg Phe Gly Pro 
        275                 280                 285             


Asn Gln Val Gly Thr His Leu Ser Leu Glu Pro Thr Gly Ala Glu Glu 
    290                 295                 300                 


Arg Gly His Arg Arg Glu Gly Arg Glu Glu Glu Gly Cys Leu Gly Gly 
305                 310                 315                 320 


Leu Ala Glu Cys Glu Arg Asp Arg Glu Gly Ala Leu Asp Gly Ser Gly 
                325                 330                 335     


Arg Ser Ala Glu Gly Leu Arg Gly Glu Met His Ala Cys Pro Gly 
            340                 345                 350     


<210>  5100
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  5100

Met Ala Lys Gly Leu Leu Val Thr Tyr Ala Leu Trp Ala Val Gly Gly 
1               5                   10                  15      


Pro Ala Gly Leu His His Leu Tyr Leu Gly Arg Asp Ser His Ala Leu 
            20                  25                  30          


Leu Trp Met Leu Thr Leu Gly Gly Gly Gly Leu Gly Trp Leu Trp Glu 
        35                  40                  45              


Phe Trp Lys Leu Pro Ser Phe Val Ala Gln Ala Asn Arg Ala Gln Gly 
    50                  55                  60                  


Gln Arg Gln Ser Pro Arg Gly Val Thr Pro Pro Leu Ser Pro Ile Arg 
65                  70                  75                  80  


Phe Ala Ala Gln Val Ile Val Gly Ile Tyr Phe Gly Leu Val Ala Leu 
                85                  90                  95      


Ile Ser Leu Ser Ser Met Val Asn Phe Tyr Ile Val Ala Leu Pro Leu 
            100                 105                 110         


Ala Val Gly Leu Gly Val Leu Leu Val Ala Ala Val Gly Asn Gln Thr 
        115                 120                 125             


Ser Asp Phe Lys Asn Thr Leu Gly Ser Ala Phe Leu Thr Ser Pro Ile 
    130                 135                 140                 


Phe Tyr Gly Arg Pro Ile Ala Ile Leu Pro Ile Ser Val Ala Ala Ser 
145                 150                 155                 160 


Ile Thr Ala Gln Arg His Arg Arg Tyr Lys Ala Leu Val Ala Ser Glu 
                165                 170                 175     


Pro Leu Ser Val Arg Leu Tyr Arg Leu Gly Leu Ala Tyr Leu Ala Phe 
            180                 185                 190         


Thr Gly Pro Leu Ala Tyr Ser Ala Leu Cys Asn Thr Ala Ala Thr Leu 
        195                 200                 205             


Ser Tyr Val Ala Glu Thr Phe Gly Ser Phe Leu Asn Trp Phe Ser Phe 
    210                 215                 220                 


Phe Pro Leu Leu Gly Arg Leu Met Glu Phe Val Leu Leu Leu Pro Tyr 
225                 230                 235                 240 


Arg Ile Trp Arg Leu Leu Met Gly Glu Thr Gly Phe Asn Ser Ser Cys 
                245                 250                 255     


Phe Gln Glu Trp Ala Lys Leu Tyr Glu Phe Val His Ser Phe Gln Asp 
            260                 265                 270         


Glu Lys Arg Gln Leu Ala Tyr Gln Val Leu Gly Leu Ser Glu Gly Ala 
        275                 280                 285             


Thr Asn Glu Glu Ile His Arg Ser Tyr Gln Glu Leu Val Lys Val Trp 
    290                 295                 300                 


His Pro Asp His Asn Leu Asp Gln Thr Glu Glu Ala Gln Arg His Phe 
305                 310                 315                 320 


Leu Glu Ile Gln Ala Ala Tyr Glu Val Leu Ser Gln Pro Arg Lys Pro 
                325                 330                 335     


Trp Gly Ser Arg Arg 
            340     


<210>  5101
<211>  541
<212>  PRT
<213>  Homo sapiens

<400>  5101

Met Ala Gly Ala Ile Ile Glu Asn Met Ser Thr Lys Lys Leu Cys Ile 
1               5                   10                  15      


Val Gly Gly Ile Leu Leu Val Phe Gln Ile Ile Ala Phe Leu Val Gly 
            20                  25                  30          


Gly Leu Ile Ala Pro Gly Pro Thr Thr Ala Val Ser Tyr Met Ser Val 
        35                  40                  45              


Lys Cys Val Asp Ala Arg Lys Asn His His Lys Thr Lys Trp Phe Val 
    50                  55                  60                  


Pro Trp Gly Pro Asn His Cys Asp Lys Ile Arg Asp Ile Glu Glu Ala 
65                  70                  75                  80  


Ile Pro Arg Glu Ile Glu Ala Asn Asp Ile Val Phe Ser Val His Ile 
                85                  90                  95      


Pro Leu Pro His Met Glu Met Ser Pro Trp Phe Gln Phe Met Leu Phe 
            100                 105                 110         


Ile Leu Gln Leu Asp Ile Ala Phe Lys Leu Asn Asn Gln Ile Arg Glu 
        115                 120                 125             


Asn Ala Glu Val Ser Met Asp Val Ser Leu Ala Tyr Arg Asp Asp Ala 
    130                 135                 140                 


Phe Ala Glu Trp Thr Glu Met Ala His Glu Arg Val Pro Arg Lys Leu 
145                 150                 155                 160 


Lys Cys Thr Phe Thr Ser Pro Lys Thr Pro Glu His Glu Gly Arg Tyr 
                165                 170                 175     


Tyr Glu Cys Asp Val Leu Pro Phe Met Glu Ile Gly Ser Val Ala His 
            180                 185                 190         


Lys Phe Tyr Leu Leu Asn Ile Arg Leu Pro Val Asn Glu Lys Lys Lys 
        195                 200                 205             


Ile Asn Val Gly Ile Gly Glu Ile Lys Asp Ile Arg Leu Val Gly Ile 
    210                 215                 220                 


His Gln Asn Gly Gly Phe Thr Lys Val Trp Phe Ala Met Lys Thr Phe 
225                 230                 235                 240 


Leu Thr Pro Ser Ile Phe Ile Ile Met Val Trp Tyr Trp Arg Arg Ile 
                245                 250                 255     


Thr Met Met Ser Arg Pro Pro Val Leu Leu Glu Lys Val Ile Phe Ala 
            260                 265                 270         


Leu Gly Ile Ser Met Thr Phe Ile Asn Ile Pro Val Glu Trp Phe Ser 
        275                 280                 285             


Ile Gly Phe Asp Trp Thr Trp Met Leu Leu Phe Gly Asp Ile Arg Gln 
    290                 295                 300                 


Gly Ile Phe Tyr Ala Met Leu Leu Ser Phe Trp Ile Ile Phe Cys Gly 
305                 310                 315                 320 


Glu His Met Met Asp Gln His Glu Arg Asn His Ile Ala Gly Tyr Trp 
                325                 330                 335     


Lys Gln Val Gly Pro Ile Ala Val Gly Ser Phe Cys Leu Phe Ile Phe 
            340                 345                 350         


Asp Met Cys Glu Arg Gly Val Gln Leu Thr Asn Pro Phe Tyr Ser Ile 
        355                 360                 365             


Trp Thr Thr Asp Ile Gly Thr Glu Leu Ala Met Ala Phe Ile Ile Val 
    370                 375                 380                 


Ala Gly Ile Cys Leu Cys Leu Tyr Phe Leu Phe Leu Cys Phe Met Val 
385                 390                 395                 400 


Phe Gln Val Phe Arg Asn Ile Ser Gly Lys Gln Ser Ser Leu Pro Ala 
                405                 410                 415     


Met Ser Lys Val Arg Arg Leu His Tyr Glu Gly Leu Ile Phe Arg Phe 
            420                 425                 430         


Lys Phe Leu Met Leu Ile Thr Leu Ala Cys Ala Ala Met Thr Val Ile 
        435                 440                 445             


Phe Phe Ile Val Ser Gln Val Thr Glu Gly His Trp Lys Trp Gly Gly 
    450                 455                 460                 


Val Thr Val Gln Val Asn Ser Ala Phe Phe Thr Gly Ile Tyr Gly Met 
465                 470                 475                 480 


Trp Asn Leu Tyr Val Phe Ala Leu Met Phe Leu Tyr Ala Pro Ser His 
                485                 490                 495     


Lys Asn Tyr Gly Glu Asp Gln Ser Asn Gly Asp Leu Gly Val His Ser 
            500                 505                 510         


Gly Glu Glu Leu Gln Leu Thr Thr Thr Ile Thr His Val Asp Gly Pro 
        515                 520                 525             


Thr Glu Ile Tyr Lys Leu Thr Arg Lys Glu Ala Gln Glu 
    530                 535                 540     


<210>  5102
<211>  1026
<212>  PRT
<213>  Homo sapiens

<400>  5102

Met Val Cys Arg Pro Val Phe Pro Cys Arg Arg Arg Phe Cys Pro Arg 
1               5                   10                  15      


Pro Phe Leu Val Gly Leu Val Val Ala Ile Cys Leu Phe Tyr Gln Thr 
            20                  25                  30          


Leu Thr Leu Arg Gly Ser Arg Lys Leu Thr Ala Ala Ala Pro Gly Ala 
        35                  40                  45              


Val Pro His Thr Ser Thr Glu Thr Gln Ala Ser Arg Cys Lys Lys Gly 
    50                  55                  60                  


Phe Ser Gln Asp Lys Gln Cys Phe Leu Leu Ser Gly Asn Ala Gln Glu 
65                  70                  75                  80  


Thr Arg Lys Val Lys Glu Ser Met Glu Thr His Phe Gly Ser His Gly 
                85                  90                  95      


Arg Arg Ala Ile Leu Tyr Arg Pro Pro Phe Tyr Ser Lys Thr Glu Leu 
            100                 105                 110         


Gln Leu His Gln His Ile Leu Thr Gln His Gly Tyr Thr Val Val Ile 
        115                 120                 125             


Ala Glu Glu Arg Leu Asn Ala Gly Leu Gly Pro Gly Leu Leu Glu Gln 
    130                 135                 140                 


Gly Asp Leu Gly Ser Trp Asp Leu Leu Ile Cys Leu Ser Ser Lys Lys 
145                 150                 155                 160 


Ala Glu Gly Thr Pro Cys Ile Ser Lys Glu Val Met Cys Gln Leu Gly 
                165                 170                 175     


Leu His Gln Lys Ala Asn Arg Leu Pro Glu Ile Gln Gln Pro Leu Cys 
            180                 185                 190         


Arg Lys Glu Gly Leu Cys Gln Ile Val Arg Arg Phe Pro Glu Leu Gln 
        195                 200                 205             


Leu Pro Val Ser Pro Ser Val Cys Leu Asp Gln Gly Met Gln Leu Lys 
    210                 215                 220                 


Pro Ser Thr Ser Ser His Leu Leu Lys Thr Val Lys Pro Arg Val Trp 
225                 230                 235                 240 


Lys Pro Gly Asp Trp Ser Arg Glu Gln Leu Asn Glu Thr Thr Val Leu 
                245                 250                 255     


Ala Pro His Glu Thr Ile Phe Arg Ala Glu Asp Leu Ser Val Ile Leu 
            260                 265                 270         


Lys Ala Tyr Val Leu Val Thr Ser Leu Thr Pro Leu Arg Ala Phe Ile 
        275                 280                 285             


His Ser Thr Gly Thr Val Trp Asn Pro Pro Lys Lys Lys Arg Phe Thr 
    290                 295                 300                 


Val Lys Leu Gln Thr Phe Phe Glu Thr Phe Leu Arg Ala Ser Ser Pro 
305                 310                 315                 320 


Gln Gln Ala Phe Asp Ile Met Lys Glu Ala Ile Gly Lys Leu Leu Leu 
                325                 330                 335     


Ala Ala Glu Val Phe Ser Glu Thr Ser Thr Leu Gly Pro Lys Thr Phe 
            340                 345                 350         


His Arg Cys Arg Phe Cys Phe Gln Leu Leu Thr Phe Asp Ile Gly Tyr 
        355                 360                 365             


Gly Ser Phe Met Tyr Pro Val Val Leu Gln Val His Glu His Leu Asn 
    370                 375                 380                 


Phe Gln Asp Tyr Asp Asn Met Asp Phe Glu Asp Gln Asn Thr Glu Glu 
385                 390                 395                 400 


Phe Leu Leu Asn Asp Thr Phe Asn Phe Leu Phe Pro Asn Glu Ser Ser 
                405                 410                 415     


Leu Ser Ile Phe Ser Glu Ile Phe Gln Arg Leu Tyr Arg Ser Asp Val 
            420                 425                 430         


Phe Lys Gly Glu Asn Tyr Gln Lys Glu Leu Asn Gln Cys Leu Ser Leu 
        435                 440                 445             


Glu Glu Ile Asn Ser Ile Met Thr Phe Ile Lys Glu Leu Gly Ser Leu 
    450                 455                 460                 


Gly Gln Phe Gln Leu Leu Phe Pro Ser Thr Thr Pro Gly Ile Gln Ser 
465                 470                 475                 480 


Leu Met His Glu Phe Tyr Asp Val Ala Asn Pro Val Gly Asn Pro Gly 
                485                 490                 495     


Ser Val Leu Thr Gln Tyr Trp Ser Leu Leu Asn Val Phe Glu Gln Phe 
            500                 505                 510         


Gln Phe Met Asn Lys Lys Thr Gln Pro His Pro Leu Glu Trp Asn Ser 
        515                 520                 525             


Phe Thr Glu Asp Lys Asn Ile Glu Lys Pro Gln Val Pro Phe Asp Ala 
    530                 535                 540                 


Ile Glu Asn Lys Lys Ala Ala Val Pro Gln Ile Lys Asn Glu Asn Lys 
545                 550                 555                 560 


Glu Ile His Cys Ser Asp Asp Glu Asn Thr Pro Cys His Ile Lys Gln 
                565                 570                 575     


Ile Phe Thr His Pro His Leu Glu Leu Asn Pro Asp Phe His Pro Lys 
            580                 585                 590         


Ile Lys Asp Tyr Tyr Cys Glu Val Pro Phe Asp Val Val Thr Val Thr 
        595                 600                 605             


Ile Gly Val Glu Thr Pro Lys Cys Leu Cys Lys Val His Leu Tyr Glu 
    610                 615                 620                 


Gln Ala Gly Pro Ser Phe Ala Ser Tyr Pro Leu Gly Leu Gly Met Asn 
625                 630                 635                 640 


Lys Ile Ser Ile Phe Val Val Asp Glu Ser Pro Ala His Gly Glu Thr 
                645                 650                 655     


Leu Ile Thr Tyr Lys Leu Thr Ile Tyr Arg Glu Asp Arg Pro Ser Leu 
            660                 665                 670         


Pro Leu Phe Glu Ala Phe Thr Ala Cys Gly Phe Val Gln Asp Cys Gly 
        675                 680                 685             


Leu Leu Ile His Pro Glu Glu Thr Cys Gly Leu Gln Pro Ile Ser Ser 
    690                 695                 700                 


Asp Tyr Ile Glu Ala Ile Leu Gln Ser Glu Leu Lys Arg Cys Pro Ser 
705                 710                 715                 720 


Gly Asp Met Lys Gly Gln Trp Ile Val Pro Cys Leu Ser Cys Ser Asp 
                725                 730                 735     


Asn Arg Thr Cys Asp Trp Arg Glu Ile Thr Trp Gln Pro His Asn Cys 
            740                 745                 750         


Gln Tyr Gly Val Leu Thr Lys Pro Gln Leu Gln Gln Cys Leu Gly Gly 
        755                 760                 765             


Arg Lys Ile Leu Phe Ile Gly Asp Ser Thr Asn Arg Gly Ile Met Tyr 
    770                 775                 780                 


Tyr Leu Ile Glu Arg Leu Asn Glu Thr Leu Gln Glu Trp Gln Lys Val 
785                 790                 795                 800 


His Gly Thr Lys Phe Tyr His Asn Val Asn Gly Gly Lys Thr Leu Ile 
                805                 810                 815     


Ser Tyr Ser Tyr Tyr Pro Gln Phe Trp Ile Ser Pro Ser Leu Arg Pro 
            820                 825                 830         


Thr Phe Glu Asn Ala Leu Glu His Leu Leu Gln Arg Ser Arg Pro Leu 
        835                 840                 845             


Glu Asn Thr Gly Gln Thr Val Leu Val Val Gly Gly Val Gln Trp Leu 
    850                 855                 860                 


Asn Ser Asn His Leu Gln Ile Ile His Lys Val Leu Lys Arg Glu Asn 
865                 870                 875                 880 


Leu Leu Asn Ile Leu Val Ile Ile Lys Thr Leu Gly Ile Gly Phe His 
                885                 890                 895     


Leu Pro Val Asp Gly Val His Phe Leu Thr Gln Ser Glu Val Gln Asn 
            900                 905                 910         


Leu Trp Lys Glu Asn Leu Ile Ile Leu Asp Thr Ala Lys Lys His Gly 
        915                 920                 925             


Tyr Glu Val Val Asp Thr Phe Thr Ile Thr Met Gly Arg Tyr Lys Glu 
    930                 935                 940                 


Phe Leu Gln Gly Lys Cys Gly Cys His Phe His Glu Val Val Lys Ser 
945                 950                 955                 960 


Lys Leu Ser Lys Glu Tyr Asn Phe Ile Lys Met Lys Arg Ser Arg Asn 
                965                 970                 975     


His Ile Met Gly Arg Tyr Phe Ser Asn Gln Ser Lys Leu Gln Gln Gly 
            980                 985                 990         


Thr Val Thr Asn Phe Arg Ser Pro  Tyr His Val Arg Gly  Pro Ile Asn 
        995                 1000                 1005             


Gln Val  Cys Ser Glu Ile Leu  Leu Ser Arg Met Cys  Ala Asn Lys 
    1010                 1015                 1020             


Arg Thr  Met 
    1025     


<210>  5103
<211>  1887
<212>  PRT
<213>  Homo sapiens

<400>  5103

Met Ala Ala Arg Gly Arg Gly Leu Leu Leu Leu Thr Leu Ser Val Leu 
1               5                   10                  15      


Leu Ala Ala Gly Pro Ser Ala Ala Ala Ala Lys Leu Asn Ile Pro Lys 
            20                  25                  30          


Val Leu Leu Pro Phe Thr Arg Ala Thr Arg Val Asn Phe Thr Leu Glu 
        35                  40                  45              


Ala Ser Glu Gly Cys Tyr Arg Trp Leu Ser Thr Arg Pro Glu Val Ala 
    50                  55                  60                  


Ser Ile Glu Pro Leu Gly Leu Asp Glu Gln Gln Cys Ser Gln Lys Ala 
65                  70                  75                  80  


Val Val Gln Ala Arg Leu Thr Gln Pro Ala Arg Leu Thr Ser Ile Ile 
                85                  90                  95      


Phe Ala Glu Asp Ile Thr Thr Gly Gln Val Leu Arg Cys Asp Ala Ile 
            100                 105                 110         


Val Asp Leu Ile His Asp Ile Gln Ile Val Ser Thr Thr Arg Glu Leu 
        115                 120                 125             


Tyr Leu Glu Asp Ser Pro Leu Glu Leu Lys Ile Gln Ala Leu Asp Ser 
    130                 135                 140                 


Glu Gly Asn Thr Phe Ser Thr Leu Ala Gly Leu Val Phe Glu Trp Thr 
145                 150                 155                 160 


Ile Val Lys Asp Ser Glu Ala Asp Arg Phe Ser Asp Ser His Asn Ala 
                165                 170                 175     


Leu Arg Ile Leu Thr Phe Leu Glu Ser Thr Tyr Ile Pro Pro Ser Tyr 
            180                 185                 190         


Ile Ser Glu Met Glu Lys Ala Ala Lys Gln Gly Asp Thr Ile Leu Val 
        195                 200                 205             


Ser Gly Met Lys Thr Gly Ser Ser Lys Leu Lys Ala Arg Ile Gln Glu 
    210                 215                 220                 


Ala Val Tyr Lys Asn Val Arg Pro Ala Glu Val Arg Leu Leu Ile Leu 
225                 230                 235                 240 


Glu Asn Ile Leu Leu Asn Pro Ala Tyr Asp Val Tyr Leu Met Val Gly 
                245                 250                 255     


Thr Ser Ile His Tyr Lys Val Gln Lys Ile Arg Gln Gly Lys Ile Thr 
            260                 265                 270         


Glu Leu Ser Met Pro Ser Asp Gln Tyr Glu Leu Gln Leu Gln Asn Ser 
        275                 280                 285             


Ile Pro Gly Pro Glu Gly Asp Pro Ala Arg Pro Val Ala Val Leu Ala 
    290                 295                 300                 


Gln Asp Thr Ser Met Val Thr Ala Leu Gln Leu Gly Gln Ser Ser Leu 
305                 310                 315                 320 


Val Leu Gly His Arg Ser Ile Arg Met Gln Gly Ala Ser Arg Leu Pro 
                325                 330                 335     


Asn Ser Thr Ile Tyr Val Val Glu Pro Gly Tyr Leu Gly Phe Thr Val 
            340                 345                 350         


His Pro Gly Asp Arg Trp Val Leu Glu Thr Gly Arg Leu Tyr Glu Ile 
        355                 360                 365             


Thr Ile Glu Val Phe Asp Lys Phe Ser Asn Lys Val Tyr Val Ser Asp 
    370                 375                 380                 


Asn Ile Arg Ile Glu Thr Val Leu Pro Ala Glu Phe Phe Glu Val Leu 
385                 390                 395                 400 


Ser Ser Ser Gln Asn Gly Ser Tyr His Arg Ile Arg Ala Leu Lys Arg 
                405                 410                 415     


Gly Gln Thr Ala Ile Asp Ala Ala Leu Thr Ser Val Val Asp Gln Asp 
            420                 425                 430         


Gly Gly Val His Ile Leu Gln Val Pro Val Trp Asn Gln Gln Glu Val 
        435                 440                 445             


Glu Ile His Ile Pro Ile Thr Leu Tyr Pro Ser Ile Leu Thr Phe Pro 
    450                 455                 460                 


Trp Gln Pro Lys Thr Gly Ala Tyr Gln Tyr Thr Ile Arg Ala His Gly 
465                 470                 475                 480 


Gly Ser Gly Asn Phe Ser Trp Ser Ser Ser Ser His Leu Val Ala Thr 
                485                 490                 495     


Val Thr Val Lys Gly Val Met Thr Thr Gly Ser Asp Ile Gly Phe Ser 
            500                 505                 510         


Val Ile Gln Ala His Asp Val Gln Asn Pro Leu His Phe Gly Glu Met 
        515                 520                 525             


Lys Val Tyr Val Ile Glu Pro His Ser Met Glu Phe Ala Pro Cys Gln 
    530                 535                 540                 


Val Glu Ala Arg Val Gly Gln Ala Leu Glu Leu Pro Leu Arg Ile Ser 
545                 550                 555                 560 


Gly Leu Met Pro Gly Gly Ala Ser Glu Val Val Thr Leu Ser Asp Cys 
                565                 570                 575     


Ser His Phe Asp Leu Ala Val Glu Val Glu Asn Gln Gly Val Phe Gln 
            580                 585                 590         


Pro Leu Pro Gly Arg Leu Pro Pro Gly Ser Glu His Cys Ser Gly Ile 
        595                 600                 605             


Arg Val Lys Ala Glu Ala Gln Gly Ser Thr Thr Leu Leu Val Ser Tyr 
    610                 615                 620                 


Arg His Gly His Val His Leu Ser Ala Lys Ile Thr Ile Ala Ala Tyr 
625                 630                 635                 640 


Leu Pro Leu Lys Ala Val Asp Pro Ser Ser Val Ala Leu Val Thr Leu 
                645                 650                 655     


Gly Ser Ser Lys Glu Met Leu Phe Glu Gly Gly Pro Arg Pro Trp Ile 
            660                 665                 670         


Leu Glu Pro Ser Lys Phe Phe Gln Asn Val Thr Ala Glu Asp Thr Asp 
        675                 680                 685             


Ser Ile Gly Leu Ala Leu Phe Ala Pro His Ser Ser Arg Asn Tyr Gln 
    690                 695                 700                 


Gln His Trp Ile Leu Val Thr Cys Gln Ala Leu Gly Glu Gln Val Ile 
705                 710                 715                 720 


Ala Leu Ser Val Gly Asn Lys Pro Ser Leu Thr Asn Pro Phe Pro Ala 
                725                 730                 735     


Val Glu Pro Ala Val Val Lys Phe Val Cys Ala Pro Pro Ser Arg Leu 
            740                 745                 750         


Thr Leu Ala Pro Val Tyr Thr Ser Pro Gln Leu Asp Met Ser Cys Pro 
        755                 760                 765             


Leu Leu Gln Gln Asn Lys Gln Val Val Pro Val Ser Ser His Arg Asn 
    770                 775                 780                 


Pro Arg Leu Asp Leu Ala Ala Tyr Asp Gln Glu Gly Arg Arg Phe Asp 
785                 790                 795                 800 


Asn Phe Ser Ser Leu Ser Ile Gln Trp Glu Ser Thr Arg Pro Val Leu 
                805                 810                 815     


Ala Ser Ile Glu Pro Glu Leu Pro Met Gln Leu Val Ser Gln Asp Asp 
            820                 825                 830         


Glu Ser Gly Gln Lys Lys Leu His Gly Leu Gln Ala Ile Leu Val His 
        835                 840                 845             


Glu Ala Ser Gly Thr Thr Ala Ile Thr Ala Thr Ala Thr Gly Tyr Gln 
    850                 855                 860                 


Glu Ser His Leu Ser Ser Ala Arg Thr Lys Gln Pro His Asp Pro Leu 
865                 870                 875                 880 


Val Pro Leu Ser Ala Ser Ile Glu Leu Ile Leu Val Glu Asp Val Arg 
                885                 890                 895     


Val Ser Pro Glu Glu Val Thr Ile Tyr Asn His Pro Gly Ile Gln Ala 
            900                 905                 910         


Glu Leu Arg Ile Arg Glu Gly Ser Gly Tyr Phe Phe Leu Asn Thr Ser 
        915                 920                 925             


Thr Ala Asp Val Val Lys Val Ala Tyr Gln Glu Ala Arg Gly Val Ala 
    930                 935                 940                 


Met Val His Pro Leu Leu Pro Gly Ser Ser Thr Ile Met Ile His Asp 
945                 950                 955                 960 


Leu Cys Leu Val Phe Pro Ala Pro Ala Lys Ala Val Val Tyr Val Ser 
                965                 970                 975     


Asp Ile Gln Glu Leu Tyr Ile Arg Val Val Asp Lys Val Glu Ile Gly 
            980                 985                 990         


Lys Thr Val Lys Ala Tyr Val Arg  Val Leu Asp Leu His  Lys Lys Pro 
        995                 1000                 1005             


Phe Leu  Ala Lys Tyr Phe Pro  Phe Met Asp Leu Lys  Leu Arg Ala 
    1010                 1015                 1020             


Ala Ser  Pro Ile Ile Thr Leu  Val Ala Leu Asp Glu  Ala Leu Asp 
    1025                 1030                 1035             


Asn Tyr  Thr Ile Thr Phe Leu  Ile Arg Gly Val Ala  Ile Gly Gln 
    1040                 1045                 1050             


Thr Ser  Leu Thr Ala Ser Val  Thr Asn Lys Ala Gly  Gln Arg Ile 
    1055                 1060                 1065             


Asn Ser  Ala Pro Gln Gln Ile  Glu Val Phe Pro Pro  Phe Arg Leu 
    1070                 1075                 1080             


Met Pro  Arg Lys Val Thr Leu  Leu Ile Gly Ala Thr  Met Gln Val 
    1085                 1090                 1095             


Thr Ser  Glu Gly Gly Pro Gln  Pro Gln Ser Asn Ile  Leu Phe Ser 
    1100                 1105                 1110             


Ile Ser  Asn Glu Ser Val Ala  Leu Val Ser Ala Ala  Gly Leu Val 
    1115                 1120                 1125             


Gln Gly  Leu Ala Ile Gly Asn  Gly Thr Val Ser Gly  Leu Val Gln 
    1130                 1135                 1140             


Ala Val  Asp Ala Glu Thr Gly  Lys Val Val Ile Ile  Ser Gln Asp 
    1145                 1150                 1155             


Leu Val  Gln Val Glu Val Leu  Leu Leu Arg Ala Val  Arg Ile Arg 
    1160                 1165                 1170             


Ala Pro  Ile Met Arg Met Arg  Thr Gly Thr Gln Met  Pro Ile Tyr 
    1175                 1180                 1185             


Val Thr  Gly Ile Thr Asn His  Gln Asn Pro Phe Ser  Phe Gly Asn 
    1190                 1195                 1200             


Ala Val  Pro Gly Leu Thr Phe  His Trp Ser Val Thr  Lys Arg Asp 
    1205                 1210                 1215             


Val Leu  Asp Leu Arg Gly Arg  His His Glu Ala Ser  Ile Arg Leu 
    1220                 1225                 1230             


Pro Ser  Gln Tyr Asn Phe Ala  Met Asn Val Leu Gly  Arg Val Lys 
    1235                 1240                 1245             


Gly Arg  Thr Gly Leu Arg Val  Val Val Lys Ala Val  Asp Pro Thr 
    1250                 1255                 1260             


Ser Gly  Gln Leu Tyr Gly Leu  Ala Arg Glu Leu Ser  Asp Glu Ile 
    1265                 1270                 1275             


Gln Val  Gln Val Phe Glu Lys  Leu Gln Leu Leu Asn  Pro Glu Ile 
    1280                 1285                 1290             


Glu Ala  Glu Gln Ile Leu Met  Ser Pro Asn Ser Tyr  Ile Lys Leu 
    1295                 1300                 1305             


Gln Thr  Asn Arg Asp Gly Ala  Ala Ser Leu Ser Tyr  Arg Val Leu 
    1310                 1315                 1320             


Asp Gly  Pro Glu Lys Val Pro  Val Val His Val Asp  Glu Lys Gly 
    1325                 1330                 1335             


Phe Leu  Ala Ser Gly Ser Met  Ile Gly Thr Ser Thr  Ile Glu Val 
    1340                 1345                 1350             


Ile Ala  Gln Glu Pro Phe Gly  Ala Asn Gln Thr Ile  Ile Val Ala 
    1355                 1360                 1365             


Val Lys  Val Ser Pro Val Ser  Tyr Leu Arg Val Ser  Met Ser Pro 
    1370                 1375                 1380             


Val Leu  His Thr Gln Asn Lys  Glu Ala Leu Val Ala  Val Pro Leu 
    1385                 1390                 1395             


Gly Met  Thr Val Thr Phe Thr  Val His Phe His Asp  Asn Ser Gly 
    1400                 1405                 1410             


Asp Val  Phe His Ala His Ser  Ser Val Leu Asn Phe  Ala Thr Asn 
    1415                 1420                 1425             


Arg Asp  Asp Phe Val Gln Ile  Gly Lys Gly Pro Thr  Asn Asn Thr 
    1430                 1435                 1440             


Cys Val  Val Arg Thr Val Ser  Val Gly Leu Thr Leu  Leu Arg Val 
    1445                 1450                 1455             


Trp Asp  Ala Glu His Pro Gly  Leu Ser Asp Phe Met  Pro Leu Pro 
    1460                 1465                 1470             


Val Leu  Gln Ala Ile Ser Pro  Glu Leu Ser Gly Ala  Met Val Val 
    1475                 1480                 1485             


Gly Asp  Val Leu Cys Leu Ala  Thr Val Leu Thr Ser  Leu Glu Gly 
    1490                 1495                 1500             


Leu Ser  Gly Thr Trp Ser Ser  Ser Ala Asn Ser Ile  Leu His Ile 
    1505                 1510                 1515             


Asp Pro  Lys Thr Gly Val Ala  Val Ala Arg Ala Val  Gly Ser Val 
    1520                 1525                 1530             


Thr Val  Tyr Tyr Glu Val Ala  Gly His Leu Arg Thr  Tyr Lys Glu 
    1535                 1540                 1545             


Val Val  Val Ser Val Pro Gln  Arg Ile Met Ala Arg  His Leu His 
    1550                 1555                 1560             


Pro Ile  Gln Thr Ser Phe Gln  Glu Ala Thr Ala Ser  Lys Val Ile 
    1565                 1570                 1575             


Val Ala  Val Gly Asp Arg Ser  Ser Asn Leu Arg Gly  Glu Cys Thr 
    1580                 1585                 1590             


Pro Thr  Gln Arg Glu Val Ile  Gln Ala Leu His Pro  Glu Thr Leu 
    1595                 1600                 1605             


Ile Ser  Cys Gln Ser Gln Phe  Lys Pro Ala Val Phe  Asp Phe Pro 
    1610                 1615                 1620             


Ser Gln  Asp Val Phe Thr Val  Glu Pro Gln Phe Asp  Thr Ala Leu 
    1625                 1630                 1635             


Gly Gln  Tyr Phe Cys Ser Ile  Thr Met His Arg Leu  Thr Asp Lys 
    1640                 1645                 1650             


Gln Arg  Lys His Leu Ser Met  Lys Lys Thr Ala Leu  Val Val Ser 
    1655                 1660                 1665             


Ala Ser  Leu Ser Ser Ser His  Phe Ser Thr Glu Gln  Val Gly Ala 
    1670                 1675                 1680             


Glu Val  Pro Phe Ser Pro Gly  Leu Phe Ala Asp Gln  Ala Glu Ile 
    1685                 1690                 1695             


Leu Leu  Ser Asn His Tyr Thr  Ser Ser Glu Ile Arg  Val Phe Gly 
    1700                 1705                 1710             


Ala Pro  Glu Val Leu Glu Asn  Leu Glu Val Lys Ser  Gly Ser Pro 
    1715                 1720                 1725             


Ala Val  Leu Ala Phe Ala Lys  Glu Lys Ser Phe Gly  Trp Pro Ser 
    1730                 1735                 1740             


Phe Ile  Thr Tyr Thr Val Gly  Val Leu Asp Pro Ala  Ala Gly Ser 
    1745                 1750                 1755             


Gln Gly  Pro Leu Ser Thr Thr  Leu Thr Phe Ser Ser  Pro Val Thr 
    1760                 1765                 1770             


Asn Gln  Ala Ile Ala Ile Pro  Val Thr Val Ala Phe  Val Val Asp 
    1775                 1780                 1785             


Arg Arg  Gly Pro Gly Pro Tyr  Gly Ala Ser Leu Phe  Gln His Phe 
    1790                 1795                 1800             


Leu Asp  Ser Tyr Gln Val Met  Phe Phe Thr Leu Phe  Ala Leu Leu 
    1805                 1810                 1815             


Ala Gly  Thr Ala Val Met Ile  Ile Ala Tyr His Thr  Val Cys Thr 
    1820                 1825                 1830             


Pro Arg  Asp Leu Ala Val Pro  Ala Ala Leu Thr Pro  Arg Ala Ser 
    1835                 1840                 1845             


Pro Gly  His Ser Pro His Tyr  Phe Ala Ala Ser Ser  Pro Thr Ser 
    1850                 1855                 1860             


Pro Asn  Ala Leu Pro Pro Ala  Arg Lys Ala Ser Pro  Pro Ser Gly 
    1865                 1870                 1875             


Leu Trp  Ser Pro Ala Tyr Ala  Ser His 
    1880                 1885         


<210>  5104
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  5104

Met Ala Phe Ser Asp Leu Thr Ser Arg Thr Val His Leu Tyr Asp Asn 
1               5                   10                  15      


Trp Ile Lys Asp Ala Asp Pro Arg Val Glu Asp Trp Leu Leu Met Ser 
            20                  25                  30          


Ser Pro Leu Pro Gln Thr Ile Leu Leu Gly Phe Tyr Val Tyr Phe Val 
        35                  40                  45              


Thr Ser Leu Gly Pro Lys Leu Met Glu Asn Arg Lys Pro Phe Glu Leu 
    50                  55                  60                  


Lys Lys Ala Met Ile Thr Tyr Asn Phe Phe Ile Val Leu Phe Ser Val 
65                  70                  75                  80  


Tyr Met Cys Tyr Glu Phe Val Met Ser Gly Trp Gly Ile Gly Tyr Ser 
                85                  90                  95      


Phe Arg Cys Asp Ile Val Asp Tyr Ser Arg Ser Pro Thr Ala Leu Arg 
            100                 105                 110         


Met Ala Arg Thr Cys Trp Leu Tyr Tyr Phe Ser Lys Phe Ile Glu Leu 
        115                 120                 125             


Leu Asp Thr Ile Phe Phe Val Leu Arg Lys Lys Asn Ser Gln Val Thr 
    130                 135                 140                 


Phe Leu His Val Phe His His Thr Ile Met Pro Trp Thr Trp Trp Phe 
145                 150                 155                 160 


Gly Val Lys Phe Ala Ala Gly Gly Leu Gly Thr Phe His Ala Leu Leu 
                165                 170                 175     


Asn Thr Ala Val His Val Val Met Tyr Ser Tyr Tyr Gly Leu Ser Ala 
            180                 185                 190         


Leu Gly Pro Ala Tyr Gln Lys Tyr Leu Trp Trp Lys Lys Tyr Leu Thr 
        195                 200                 205             


Ser Leu Gln Leu Val Gln Phe Val Ile Val Ala Ile His Ile Ser Gln 
    210                 215                 220                 


Phe Phe Phe Met Glu Asp Cys Lys Tyr Gln Phe Pro Val Phe Ala Cys 
225                 230                 235                 240 


Ile Ile Met Ser Tyr Ser Phe Met Phe Leu Leu Leu Phe Leu His Phe 
                245                 250                 255     


Trp Tyr Arg Ala Tyr Thr Lys Gly Gln Arg Leu Pro Lys Thr Val Lys 
            260                 265                 270         


Asn Gly Thr Cys Lys Asn Lys Asp Asn 
        275                 280     


<210>  5105
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  5105

Met Thr Lys Thr Ala Leu Leu Lys Leu Phe Val Ala Ile Val Ile Thr 
1               5                   10                  15      


Phe Ile Leu Ile Leu Pro Glu Tyr Phe Lys Thr Pro Lys Glu Arg Thr 
            20                  25                  30          


Leu Glu Leu Ser Cys Leu Glu Val Cys Leu Gln Ser Asn Phe Thr Tyr 
        35                  40                  45              


Ser Leu Ser Ser Leu Asn Phe Ser Phe Val Thr Phe Leu Gln Pro Val 
    50                  55                  60                  


Arg Glu Thr Gln Ile Ile Met Arg Ile Phe Leu Asn Pro Ser Asn Phe 
65                  70                  75                  80  


Arg Asn Phe Thr Arg Thr Cys Gln Asp Ile Thr Gly Glu Phe Lys Met 
                85                  90                  95      


Cys Ser Ser Cys Leu Val Cys Glu Ser Lys Gly Asn Met Asp Phe Ile 
            100                 105                 110         


Ser Gln Glu Gln Thr Ser Lys Val Leu Ile Arg Arg Gly Ser Met Glu 
        115                 120                 125             


Val Lys Ala Asn Asp Phe His Ser Pro Cys Gln His Phe Asn Phe Ser 
    130                 135                 140                 


Val Ala Pro Leu Val Asp His Leu Glu Glu Tyr Asn Thr Thr Cys His 
145                 150                 155                 160 


Leu Lys Asn His Thr Gly Arg Ser Thr Ile Met Glu Asp Glu Pro Ser 
                165                 170                 175     


Lys Glu Lys Ser Ile Asn Tyr Thr Cys Arg Ile Met Glu Tyr Pro Asn 
            180                 185                 190         


Asp Cys Ile His Ile Ser Leu His Leu Glu Met Asp Ile Lys Asn Ile 
        195                 200                 205             


Thr Cys Ser Met Lys Ile Thr Trp Tyr Ile Leu Val Leu Leu Val Phe 
    210                 215                 220                 


Ile Phe Leu Ile Ile Leu Thr Ile Arg Lys Ile Leu Glu Gly Gln Arg 
225                 230                 235                 240 


Arg Val Gln Lys Trp Gln Ser His Arg Asp Lys Pro Thr Ser Val Leu 
                245                 250                 255     


Leu Arg Gly Ser Asp Ser Glu Lys Leu Arg Ala Leu Asn Val Gln Val 
            260                 265                 270         


Leu Ser Ala Glu Thr Thr Gln Arg Leu Pro Leu Asp Gln Val Gln Glu 
        275                 280                 285             


Val Leu Pro Pro Ile Pro Glu Leu 
    290                 295     


<210>  5106
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  5106

Met Ser Arg Val Val Ser Leu Leu Leu Gly Ala Ala Leu Leu Cys Gly 
1               5                   10                  15      


His Gly Ala Phe Cys Arg Arg Val Val Ser Gly Gln Lys Val Cys Phe 
            20                  25                  30          


Ala Asp Phe Lys His Pro Cys Tyr Lys Met Ala Tyr Phe His Glu Leu 
        35                  40                  45              


Ser Ser Arg Val Ser Phe Gln Glu Ala Arg Leu Ala Cys Glu Ser Glu 
    50                  55                  60                  


Gly Gly Val Leu Leu Ser Leu Glu Asn Glu Ala Glu Gln Lys Leu Ile 
65                  70                  75                  80  


Glu Ser Met Leu Gln Asn Leu Thr Lys Pro Gly Thr Gly Ile Ser Asp 
                85                  90                  95      


Gly Asp Phe Trp Ile Gly Leu Trp Arg Asn Gly Asp Gly Gln Thr Ser 
            100                 105                 110         


Gly Ala Cys Pro Asp Leu Tyr Gln Trp Ser Asp Gly Ser Asn Ser Gln 
        115                 120                 125             


Tyr Arg Asn Trp Tyr Thr Asp Glu Pro Ser Cys Gly Ser Glu Lys Cys 
    130                 135                 140                 


Val Val Met Tyr His Gln Pro Thr Ala Asn Pro Gly Leu Gly Gly Pro 
145                 150                 155                 160 


Tyr Leu Tyr Gln Trp Asn Asp Asp Arg Cys Asn Met Lys His Asn Tyr 
                165                 170                 175     


Ile Cys Lys Tyr Glu Pro Glu Ile Asn Pro Thr Ala Pro Val Glu Lys 
            180                 185                 190         


Pro Tyr Leu Thr Asn Gln Pro Gly Asp Thr His Gln Asn Val Val Val 
        195                 200                 205             


Thr Glu Ala Gly Ile Ile Pro Asn Leu Ile Tyr Val Val Ile Pro Thr 
    210                 215                 220                 


Ile Pro Leu Leu Leu Leu Ile Leu Val Ala Phe Gly Thr Cys Cys Phe 
225                 230                 235                 240 


Gln Met Leu His Lys Ser Lys Gly Arg Thr Lys Thr Ser Pro Asn Gln 
                245                 250                 255     


Ser Thr Leu Trp Ile Ser Lys Ser Thr Arg Lys Glu Ser Gly Met Glu 
            260                 265                 270         


Val 
    


<210>  5107
<211>  643
<212>  PRT
<213>  Homo sapiens

<400>  5107

Met Ala Ala Val Leu Ala Leu Arg Val Val Ala Gly Leu Ala Ala Ala 
1               5                   10                  15      


Ala Leu Val Ala Met Leu Leu Glu His Tyr Gly Leu Ala Gly Gln Pro 
            20                  25                  30          


Ser Pro Leu Pro Arg Pro Ala Pro Pro Arg Arg Pro His Pro Ala Pro 
        35                  40                  45              


Gly Pro Gly Asp Ser Asn Ile Phe Trp Gly Leu Gln Ile Ser Asp Ile 
    50                  55                  60                  


His Leu Ser Arg Phe Arg Asp Pro Gly Arg Ala Val Asp Leu Glu Lys 
65                  70                  75                  80  


Phe Cys Ser Glu Thr Ile Asp Ile Ile Gln Pro Ala Leu Val Leu Ala 
                85                  90                  95      


Thr Gly Asp Leu Thr Asp Ala Lys Thr Lys Glu Gln Leu Gly Ser Arg 
            100                 105                 110         


Gln His Glu Val Glu Trp Gln Thr Tyr Gln Gly Ile Leu Lys Lys Thr 
        115                 120                 125             


Arg Val Met Glu Lys Thr Lys Trp Leu Asp Ile Lys Gly Asn His Asp 
    130                 135                 140                 


Ala Phe Asn Ile Pro Ser Leu Asp Ser Ile Lys Asn Tyr Tyr Arg Lys 
145                 150                 155                 160 


Tyr Ser Ala Val Arg Arg Asp Gly Ser Phe His Tyr Val His Ser Thr 
                165                 170                 175     


Pro Phe Gly Asn Tyr Ser Phe Ile Cys Val Asp Ala Thr Val Asn Pro 
            180                 185                 190         


Gly Pro Lys Arg Pro Tyr Asn Phe Phe Gly Ile Leu Asp Lys Lys Lys 
        195                 200                 205             


Met Glu Glu Leu Leu Leu Leu Ala Lys Glu Ser Ser Arg Ser Asn His 
    210                 215                 220                 


Thr Ile Trp Phe Gly His Phe Thr Thr Ser Thr Ile Leu Ser Pro Ser 
225                 230                 235                 240 


Pro Gly Ile Arg Ser Ile Met Ser Ser Ala Ile Ala Tyr Leu Cys Gly 
                245                 250                 255     


His Leu His Thr Leu Gly Gly Leu Met Pro Val Leu His Thr Arg His 
            260                 265                 270         


Phe Gln Gly Thr Leu Glu Leu Glu Val Gly Asp Trp Lys Asp Asn Arg 
        275                 280                 285             


Arg Tyr Arg Ile Phe Ala Phe Asp His Asp Leu Phe Ser Phe Ala Asp 
    290                 295                 300                 


Leu Ile Phe Gly Lys Trp Pro Val Val Leu Ile Thr Asn Pro Lys Ser 
305                 310                 315                 320 


Leu Leu Tyr Ser Cys Gly Glu His Glu Pro Leu Glu Arg Leu Leu His 
                325                 330                 335     


Ser Thr His Ile Arg Val Leu Ala Phe Ser Leu Ser Ser Ile Thr Ser 
            340                 345                 350         


Val Thr Val Lys Ile Asp Gly Val His Leu Gly Gln Ala Val His Val 
        355                 360                 365             


Ser Gly Pro Ile Phe Val Leu Lys Trp Asn Pro Arg Asn Tyr Ser Ser 
    370                 375                 380                 


Gly Thr His Asn Ile Glu Val Ile Val Gln Asp Ser Ala Gly Arg Ser 
385                 390                 395                 400 


Lys Ser Val His His Ile Phe Ser Val Gln Glu Asn Asn His Leu Ser 
                405                 410                 415     


Phe Asp Pro Leu Ala Ser Phe Ile Leu Arg Thr Asp His Tyr Ile Met 
            420                 425                 430         


Ala Arg Val Leu Phe Val Leu Ile Val Leu Ser Gln Leu Thr Ile Leu 
        435                 440                 445             


Ile Ile Phe Arg Tyr Arg Gly Tyr Pro Glu Leu Lys Glu Pro Ser Gly 
    450                 455                 460                 


Phe Ile Asn Leu Thr Ser Phe Ser Leu His Val Leu Ser Lys Ile Asn 
465                 470                 475                 480 


Ile Phe Tyr Tyr Ser Val Leu Leu Leu Thr Leu Tyr Thr Val Leu Gly 
                485                 490                 495     


Pro Trp Phe Phe Gly Glu Ile Ile Asp Gly Lys Phe Gly Cys Cys Phe 
            500                 505                 510         


Ser Phe Gly Ile Phe Val Asn Gly His Phe Leu Gln Gly Ser Ile Thr 
        515                 520                 525             


Phe Ile Ile Gly Ile Leu Gln Leu Ala Phe Phe Asn Ile Pro Leu Met 
    530                 535                 540                 


Ala Tyr Met Cys Trp Ser Leu Leu Gln Arg Cys Phe Gly His Asn Phe 
545                 550                 555                 560 


Arg Ser His Leu His Gln Arg Lys Tyr Leu Lys Ile Met Pro Val His 
                565                 570                 575     


Leu Leu Met Leu Leu Leu Tyr Ile Trp Gln Val Tyr Ser Cys Tyr Phe 
            580                 585                 590         


Leu Tyr Ala Thr Tyr Gly Thr Leu Ala Phe Leu Phe Ser Pro Leu Arg 
        595                 600                 605             


Thr Trp Leu Thr Leu Leu Thr Pro Val Leu Ile Arg Tyr Val Trp Thr 
    610                 615                 620                 


Leu Asn Ser Thr Lys Phe Gly Ile Phe Met Val Gln Leu Lys Ser His 
625                 630                 635                 640 


Leu Ser Ser 
            


<210>  5108
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  5108

Met Met Pro Ser Cys Asn Arg Ser Cys Ser Cys Ser Arg Gly Pro Ser 
1               5                   10                  15      


Val Glu Asp Gly Lys Trp Tyr Gly Val Arg Ser Tyr Leu His Leu Phe 
            20                  25                  30          


Tyr Glu Asp Cys Ala Gly Thr Ala Leu Ser Asp Asp Pro Glu Gly Pro 
        35                  40                  45              


Pro Val Leu Cys Pro Arg Arg Pro Trp Pro Ser Leu Cys Trp Lys Ile 
    50                  55                  60                  


Ser Leu Ser Ser Gly Thr Leu Leu Leu Leu Leu Gly Val Ala Ala Leu 
65                  70                  75                  80  


Thr Thr Gly Tyr Ala Val Pro Pro Lys Leu Glu Gly Ile Gly Glu Gly 
                85                  90                  95      


Glu Phe Leu Val Leu Asp Gln Arg Ala Ala Asp Tyr Asn Gln Ala Leu 
            100                 105                 110         


Gly Thr Cys Arg Leu Ala Gly Thr Ala Leu Cys Val Ala Ala Gly Val 
        115                 120                 125             


Leu Leu Ala Ile Cys Leu Phe Trp Ala Met Ile Gly Trp Leu Ser Gln 
    130                 135                 140                 


Asp Thr Lys Ala Glu Pro Leu Asp Pro Glu Ala Asp Ser His Val Glu 
145                 150                 155                 160 


Val Phe Gly Asp Glu Pro Glu Gln Gln Leu Ser Pro Ile Phe Arg Asn 
                165                 170                 175     


Ala Ser Gly Gln Ser Trp Phe Ser Pro Pro Ala Ser Pro Phe Gly Gln 
            180                 185                 190         


Ser Ser Val Gln Thr Ile Gln Pro Lys Arg Asp Ser 
        195                 200                 


<210>  5109
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  5109

Met Ala Gly Arg Arg Leu Asn Leu Arg Trp Ala Leu Ser Val Leu Cys 
1               5                   10                  15      


Val Leu Leu Met Ala Glu Thr Val Ser Gly Thr Arg Gly Ser Ser Thr 
            20                  25                  30          


Gly Ala His Ile Ser Pro Gln Phe Pro Ala Ser Gly Val Asn Gln Thr 
        35                  40                  45              


Pro Val Val Asp Cys Arg Lys Val Cys Gly Leu Asn Val Ser Asp Arg 
    50                  55                  60                  


Cys Asp Phe Ile Arg Thr Asn Pro Asp Cys His Ser Asp Gly Gly Tyr 
65                  70                  75                  80  


Leu Asp Tyr Leu Glu Gly Ile Phe Cys His Phe Pro Pro Ser Leu Leu 
                85                  90                  95      


Pro Leu Ala Val Thr Leu Tyr Val Ser Trp Leu Leu Tyr Leu Phe Leu 
            100                 105                 110         


Ile Leu Gly Val Thr Ala Ala Lys Phe Phe Cys Pro Asn Leu Ser Ala 
        115                 120                 125             


Ile Ser Thr Thr Leu Lys Leu Ser His Asn Val Ala Gly Val Thr Phe 
    130                 135                 140                 


Leu Ala Phe Gly Asn Gly Ala Pro Asp Ile Phe Ser Ala Leu Val Ala 
145                 150                 155                 160 


Phe Ser Asp Pro His Thr Ala Gly Leu Ala Leu Gly Ala Leu Phe Gly 
                165                 170                 175     


Ala Gly Val Leu Val Thr Thr Val Val Ala Gly Gly Ile Thr Ile Leu 
            180                 185                 190         


His Pro Phe Met Ala Ala Ser Arg Pro Phe Phe Arg Asp Ile Val Phe 
        195                 200                 205             


Tyr Met Val Ala Val Phe Leu Thr Phe Leu Met Leu Phe Arg Gly Arg 
    210                 215                 220                 


Val Thr Leu Ala Trp Ala Leu Gly Tyr Leu Gly Leu Tyr Val Phe Tyr 
225                 230                 235                 240 


Val Val Thr Val Ile Leu Cys Thr Trp Ile Tyr Gln Arg Gln Arg Arg 
                245                 250                 255     


Gly Ser Leu Phe Cys Pro Met Pro Val Thr Pro Glu Ile Leu Ser Asp 
            260                 265                 270         


Ser Glu Glu Asp Arg Val Ser Ser Asn Thr Asn Ser Tyr Asp Tyr Gly 
        275                 280                 285             


Asp Glu Tyr Arg Pro Leu Phe Phe Tyr Gln Glu Thr Thr Ala Gln Ile 
    290                 295                 300                 


Leu Val Arg Ala Leu Asn Pro Leu Asp Tyr Met Lys Trp Arg Arg Lys 
305                 310                 315                 320 


Ser Ala Tyr Trp Lys Ala Leu Lys Val Phe Lys Leu Pro Val Glu Phe 
                325                 330                 335     


Leu Leu Leu Leu Thr Val Pro Val Val Asp Pro Asp Lys Asp Asp Gln 
            340                 345                 350         


Asn Trp Lys Arg Pro Leu Asn Cys Leu His Leu Val Ile Ser Pro Leu 
        355                 360                 365             


Val Val Val Leu Thr Leu Gln Ser Gly Thr Tyr Gly Val Tyr Glu Ile 
    370                 375                 380                 


Gly Gly Leu Val Pro Val Trp Val Val Val Val Ile Ala Gly Thr Ala 
385                 390                 395                 400 


Leu Ala Ser Val Thr Phe Phe Ala Thr Ser Asp Ser Gln Pro Pro Arg 
                405                 410                 415     


Leu His Trp Leu Phe Ala Phe Leu Gly Phe Leu Thr Ser Ala Leu Trp 
            420                 425                 430         


Ile Asn Ala Ala Ala Thr Glu Val Val Asn Ile Leu Arg Ser Leu Gly 
        435                 440                 445             


Val Val Phe Arg Leu Ser Asn Thr Val Leu Gly Leu Thr Leu Leu Ala 
    450                 455                 460                 


Trp Gly Asn Ser Ile Gly Asp Ala Phe Ser Asp Phe Thr Leu Ala Arg 
465                 470                 475                 480 


Gln Gly Tyr Pro Arg Met Ala Phe Ser Ala Cys Phe Gly Gly Ile Ile 
                485                 490                 495     


Phe Asn Ile Leu Val Gly Val Gly Leu Gly Cys Leu Leu Gln Ile Ser 
            500                 505                 510         


Arg Ser His Thr Glu Val Lys Leu Glu Pro Asp Gly Leu Leu Val Trp 
        515                 520                 525             


Val Leu Ala Gly Ala Leu Gly Leu Ser Leu Val Phe Ser Leu Val Ser 
    530                 535                 540                 


Val Pro Leu Gln Cys Phe Gln Leu Ser Arg Val Tyr Gly Phe Cys Leu 
545                 550                 555                 560 


Leu Leu Phe Tyr Leu Asn Phe Leu Val Val Ala Leu Leu Thr Glu Phe 
                565                 570                 575     


Gly Val Ile His Leu Lys Ser Met 
            580                 


<210>  5110
<211>  476
<212>  PRT
<213>  Homo sapiens

<400>  5110

Met Arg Val Phe Leu Leu Cys Ala Tyr Ile Leu Leu Leu Met Val Ser 
1               5                   10                  15      


Gln Leu Arg Ala Val Ser Phe Pro Glu Asp Asp Glu Pro Leu Asn Thr 
            20                  25                  30          


Val Asp Tyr His Tyr Ser Arg Gln Tyr Pro Val Phe Arg Gly Arg Pro 
        35                  40                  45              


Ser Gly Asn Glu Ser Gln His Arg Leu Asp Phe Gln Leu Met Leu Lys 
    50                  55                  60                  


Ile Arg Asp Thr Leu Tyr Ile Ala Gly Arg Asp Gln Val Tyr Thr Val 
65                  70                  75                  80  


Asn Leu Asn Glu Met Pro Lys Thr Glu Val Ile Pro Asn Lys Lys Leu 
                85                  90                  95      


Thr Trp Arg Ser Arg Gln Gln Asp Arg Glu Asn Cys Ala Met Lys Gly 
            100                 105                 110         


Lys His Lys Asp Glu Cys His Asn Phe Ile Lys Val Phe Val Pro Arg 
        115                 120                 125             


Asn Asp Glu Met Val Phe Val Cys Gly Thr Asn Ala Phe Asn Pro Met 
    130                 135                 140                 


Cys Arg Tyr Tyr Arg Leu Ser Thr Leu Glu Tyr Asp Gly Glu Glu Ile 
145                 150                 155                 160 


Ser Gly Leu Ala Arg Cys Pro Phe Asp Ala Arg Gln Thr Asn Val Ala 
                165                 170                 175     


Leu Phe Ala Asp Gly Lys Leu Tyr Ser Ala Thr Val Ala Asp Phe Leu 
            180                 185                 190         


Ala Ser Asp Ala Val Ile Tyr Arg Ser Met Gly Asp Gly Ser Ala Leu 
        195                 200                 205             


Arg Thr Ile Lys Tyr Asp Ser Lys Trp Ile Lys Glu Pro His Phe Leu 
    210                 215                 220                 


His Ala Ile Glu Tyr Gly Asn Tyr Val Tyr Phe Phe Phe Arg Glu Ile 
225                 230                 235                 240 


Ala Val Glu His Asn Asn Leu Gly Lys Ala Val Tyr Ser Arg Val Ala 
                245                 250                 255     


Arg Ile Cys Lys Asn Asp Met Gly Gly Ser Gln Arg Val Leu Glu Lys 
            260                 265                 270         


His Trp Thr Ser Phe Leu Lys Ala Arg Leu Asn Cys Ser Val Pro Gly 
        275                 280                 285             


Asp Ser Phe Phe Tyr Phe Asp Val Leu Gln Ser Ile Thr Asp Ile Ile 
    290                 295                 300                 


Gln Ile Asn Gly Ile Pro Thr Val Val Gly Val Phe Thr Thr Gln Leu 
305                 310                 315                 320 


Asn Ser Ile Pro Gly Ser Ala Val Cys Ala Phe Ser Met Asp Asp Ile 
                325                 330                 335     


Glu Lys Val Phe Lys Gly Arg Phe Lys Glu Gln Lys Thr Pro Asp Ser 
            340                 345                 350         


Val Trp Thr Ala Val Pro Glu Asp Lys Val Pro Lys Pro Arg Pro Gly 
        355                 360                 365             


Cys Cys Ala Lys His Gly Leu Ala Glu Ala Tyr Lys Thr Ser Ile Asp 
    370                 375                 380                 


Phe Pro Asp Glu Thr Leu Ser Phe Ile Lys Ser His Pro Leu Met Asp 
385                 390                 395                 400 


Ser Ala Val Pro Pro Ile Ala Asp Glu Pro Trp Phe Thr Lys Thr Arg 
                405                 410                 415     


Val Arg Tyr Arg Leu Thr Ala Ile Ser Val Asp His Ser Ala Gly Pro 
            420                 425                 430         


Tyr Gln Asn Tyr Thr Val Ile Phe Val Gly Ser Glu Ala Gly Met Val 
        435                 440                 445             


Leu Lys Val Leu Ala Lys Thr Ser Pro Phe Ser Leu Asn Asp Ser Val 
    450                 455                 460                 


Leu Leu Glu Glu Ile Glu Ala Tyr Asn His Ala Lys 
465                 470                 475     


<210>  5111
<211>  1566
<212>  PRT
<213>  Homo sapiens

<400>  5111

Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His 
1               5                   10                  15      


Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser 
            20                  25                  30          


Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln 
        35                  40                  45              


Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp 
    50                  55                  60                  


Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp 
65                  70                  75                  80  


Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile 
                85                  90                  95      


Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly 
            100                 105                 110         


Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys 
        115                 120                 125             


Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn 
    130                 135                 140                 


Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu 
145                 150                 155                 160 


Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Ile Gly Gln Gly 
                165                 170                 175     


Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser 
            180                 185                 190         


Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val 
        195                 200                 205             


Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys 
    210                 215                 220                 


Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu 
225                 230                 235                 240 


Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln 
                245                 250                 255     


His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile 
            260                 265                 270         


Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala 
        275                 280                 285             


Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln 
    290                 295                 300                 


Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln 
305                 310                 315                 320 


Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala 
                325                 330                 335     


Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu 
            340                 345                 350         


Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu 
        355                 360                 365             


Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His 
    370                 375                 380                 


Leu Val Arg Asp Val Lys Lys Arg Glu Tyr Pro Gly Phe Gly Trp Ile 
385                 390                 395                 400 


Tyr Phe Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp 
                405                 410                 415     


Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn 
            420                 425                 430         


Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro 
        435                 440                 445             


Lys Arg Pro Lys Ala Leu Lys Leu Leu Gly Met Glu Asp Asp Ile Pro 
    450                 455                 460                 


Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp 
465                 470                 475                 480 


Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His 
                485                 490                 495     


Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu 
            500                 505                 510         


Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala 
        515                 520                 525             


Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met 
    530                 535                 540                 


Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly 
545                 550                 555                 560 


Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln 
                565                 570                 575     


Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala 
            580                 585                 590         


Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala 
        595                 600                 605             


His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu 
    610                 615                 620                 


Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu 
625                 630                 635                 640 


Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro 
                645                 650                 655     


Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu 
            660                 665                 670         


Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu 
        675                 680                 685             


Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp 
    690                 695                 700                 


Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys 
705                 710                 715                 720 


Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr 
                725                 730                 735     


Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val 
            740                 745                 750         


Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr 
        755                 760                 765             


Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu 
    770                 775                 780                 


Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp 
785                 790                 795                 800 


Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile 
                805                 810                 815     


Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr 
            820                 825                 830         


Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly 
        835                 840                 845             


Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile Gly Lys Met Met 
    850                 855                 860                 


Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val Val Leu Met Ser 
865                 870                 875                 880 


Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn Glu Glu Pro Ser 
                885                 890                 895     


Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met Pro Tyr Trp Met Ile Tyr 
            900                 905                 910         


Gly Glu Val Phe Ala Asp Gln Ile Asp Pro Pro Cys Gly Gln Asn Glu 
        915                 920                 925             


Thr Arg Glu Asp Gly Lys Ile Ile Gln Leu Pro Pro Cys Lys Thr Gly 
    930                 935                 940                 


Ala Trp Ile Val Pro Ala Ile Met Ala Cys Tyr Leu Leu Val Ala Asn 
945                 950                 955                 960 


Ile Leu Leu Val Asn Leu Leu Ile Ala Val Phe Asn Asn Thr Phe Phe 
                965                 970                 975     


Glu Val Lys Ser Ile Ser Asn Gln Val Trp Lys Phe Gln Arg Tyr Gln 
            980                 985                 990         


Leu Ile Met Thr Phe His Glu Arg  Pro Val Leu Pro Pro  Pro Leu Ile 
        995                 1000                 1005             


Ile Phe  Ser His Met Thr Met  Ile Phe Gln His Leu  Cys Cys Arg 
    1010                 1015                 1020             


Trp Arg  Lys His Glu Ser Asp  Pro Asp Glu Arg Asp  Tyr Gly Leu 
    1025                 1030                 1035             


Lys Leu  Phe Ile Thr Asp Asp  Glu Leu Lys Lys Val  His Asp Phe 
    1040                 1045                 1050             


Glu Glu  Gln Cys Ile Glu Glu  Tyr Phe Arg Glu Lys  Asp Asp Arg 
    1055                 1060                 1065             


Phe Asn  Ser Ser Asn Asp Glu  Arg Ile Arg Val Thr  Ser Glu Arg 
    1070                 1075                 1080             


Val Glu  Asn Met Ser Met Arg  Leu Glu Glu Val Asn  Glu Arg Glu 
    1085                 1090                 1095             


His Ser  Met Lys Ala Ser Leu  Gln Thr Val Asp Ile  Arg Leu Ala 
    1100                 1105                 1110             


Gln Leu  Glu Asp Leu Ile Gly  Arg Met Ala Thr Ala  Leu Glu Arg 
    1115                 1120                 1125             


Leu Thr  Gly Leu Glu Arg Ala  Glu Ser Asn Lys Ile  Arg Ser Arg 
    1130                 1135                 1140             


Thr Ser  Ser Asp Cys Thr Asp  Ala Ala Tyr Ile Val  Arg Gln Ser 
    1145                 1150                 1155             


Ser Phe  Asn Ser Gln Glu Gly  Asn Thr Phe Lys Leu  Gln Glu Ser 
    1160                 1165                 1170             


Ile Asp  Pro Ala Gly Glu Glu  Thr Met Ser Pro Thr  Ser Pro Thr 
    1175                 1180                 1185             


Leu Met  Pro Arg Met Arg Ser  His Ser Phe Tyr Ser  Val Asn Met 
    1190                 1195                 1200             


Lys Asp  Lys Gly Gly Ile Glu  Lys Leu Glu Ser Ile  Phe Lys Glu 
    1205                 1210                 1215             


Arg Ser  Leu Ser Leu His Arg  Ala Thr Ser Ser His  Ser Val Ala 
    1220                 1225                 1230             


Lys Glu  Pro Lys Ala Pro Ala  Ala Pro Ala Asn Thr  Leu Ala Ile 
    1235                 1240                 1245             


Val Pro  Asp Ser Arg Arg Pro  Ser Ser Cys Ile Asp  Ile Tyr Val 
    1250                 1255                 1260             


Ser Ala  Met Asp Glu Leu His  Cys Asp Ile Asp Pro  Leu Asp Asn 
    1265                 1270                 1275             


Ser Val  Asn Ile Leu Gly Leu  Gly Glu Pro Ser Phe  Ser Thr Pro 
    1280                 1285                 1290             


Val Pro  Ser Thr Ala Pro Ser  Ser Ser Ala Tyr Ala  Thr Leu Ala 
    1295                 1300                 1305             


Pro Thr  Asp Arg Pro Pro Ser  Arg Ser Ile Asp Phe  Glu Asp Ile 
    1310                 1315                 1320             


Thr Ser  Met Asp Thr Arg Ser  Phe Ser Ser Asp Tyr  Thr His Leu 
    1325                 1330                 1335             


Pro Glu  Cys Gln Asn Pro Trp  Asp Ser Glu Pro Pro  Met Tyr His 
    1340                 1345                 1350             


Thr Ile  Glu Arg Ser Lys Ser  Ser Arg Tyr Leu Ala  Thr Thr Pro 
    1355                 1360                 1365             


Phe Leu  Leu Glu Glu Ala Pro  Ile Val Lys Ser His  Ser Phe Met 
    1370                 1375                 1380             


Phe Ser  Pro Ser Arg Ser Tyr  Tyr Ala Asn Phe Gly  Val Pro Val 
    1385                 1390                 1395             


Lys Thr  Ala Glu Tyr Thr Ser  Ile Thr Asp Cys Ile  Asp Thr Arg 
    1400                 1405                 1410             


Cys Val  Asn Ala Pro Gln Ala  Ile Ala Asp Arg Ala  Ala Phe Pro 
    1415                 1420                 1425             


Gly Gly  Leu Gly Asp Lys Val  Glu Asp Leu Thr Cys  Cys His Pro 
    1430                 1435                 1440             


Glu Arg  Glu Ala Glu Leu Ser  His Pro Ser Ser Asp  Ser Glu Glu 
    1445                 1450                 1455             


Asn Glu  Ala Lys Gly Arg Arg  Ala Thr Ile Ala Ile  Ser Ser Gln 
    1460                 1465                 1470             


Glu Gly  Asp Asn Ser Glu Arg  Thr Leu Ser Asn Asn  Ile Thr Val 
    1475                 1480                 1485             


Pro Lys  Ile Glu Arg Ala Asn  Ser Tyr Ser Ala Glu  Glu Pro Ser 
    1490                 1495                 1500             


Ala Pro  Tyr Ala His Thr Arg  Lys Ser Phe Ser Ile  Ser Asp Lys 
    1505                 1510                 1515             


Leu Asp  Arg Gln Arg Asn Thr  Ala Ser Leu Arg Asn  Pro Phe Gln 
    1520                 1525                 1530             


Arg Ser  Lys Ser Ser Lys Pro  Glu Gly Arg Gly Asp  Ser Leu Ser 
    1535                 1540                 1545             


Met Arg  Arg Leu Ser Arg Thr  Ser Ala Phe Gln Ser  Phe Glu Ser 
    1550                 1555                 1560             


Lys His  Asn 
    1565     


<210>  5112
<211>  922
<212>  PRT
<213>  Homo sapiens

<400>  5112

Met Phe Leu His Ser Val Asn Leu Trp Asn Leu Ala Phe Tyr Val Phe 
1               5                   10                  15      


Met Val Phe Leu Ala Thr Leu Gly Leu Trp Asp Val Phe Phe Gly Phe 
            20                  25                  30          


Glu Glu Asn Lys Cys Ser Met Ser Tyr Met Phe Glu Tyr Pro Glu Tyr 
        35                  40                  45              


Gln Lys Ile Glu Leu Pro Lys Lys Leu Ala Lys Arg Tyr Pro Ala Tyr 
    50                  55                  60                  


Glu Leu Tyr Leu Tyr Gly Glu Gly Ser Tyr Ala Glu Glu His Lys Ile 
65                  70                  75                  80  


Leu Pro Leu Thr Gly Ile Pro Val Leu Phe Leu Pro Gly Asn Ala Gly 
                85                  90                  95      


Ser Tyr Lys Gln Val Arg Ser Ile Gly Ser Ile Ala Leu Arg Lys Ala 
            100                 105                 110         


Glu Asp Ile Asp Phe Lys Tyr His Phe Asp Phe Phe Ser Val Asn Phe 
        115                 120                 125             


Asn Glu Glu Leu Val Ala Leu Tyr Gly Gly Ser Leu Gln Lys Gln Thr 
    130                 135                 140                 


Lys Phe Val His Glu Cys Ile Lys Thr Ile Leu Lys Leu Tyr Lys Gly 
145                 150                 155                 160 


Gln Glu Phe Ala Pro Lys Ser Val Ala Ile Ile Gly His Ser Met Gly 
                165                 170                 175     


Gly Leu Val Ala Arg Ala Leu Leu Thr Leu Lys Asn Phe Lys His Asp 
            180                 185                 190         


Leu Ile Asn Leu Leu Ile Thr Gln Ala Thr Pro His Val Ala Pro Val 
        195                 200                 205             


Met Pro Leu Asp Arg Phe Ile Thr Asp Phe Tyr Thr Thr Val Asn Asn 
    210                 215                 220                 


Tyr Trp Ile Leu Asn Ala Arg His Ile Asn Leu Thr Thr Leu Ser Val 
225                 230                 235                 240 


Ala Gly Gly Phe Arg Asp Tyr Gln Val Arg Ser Gly Leu Thr Phe Leu 
                245                 250                 255     


Pro Lys Leu Ser His His Thr Ser Ala Leu Ser Val Val Ser Ser Ala 
            260                 265                 270         


Val Pro Lys Thr Trp Val Ser Thr Asp His Leu Ser Ile Val Trp Cys 
        275                 280                 285             


Lys Gln Leu Gln Leu Thr Thr Val Arg Ala Phe Phe Asp Leu Ile Asp 
    290                 295                 300                 


Ala Asp Thr Lys Gln Ile Thr Gln Asn Ser Lys Lys Lys Leu Ser Val 
305                 310                 315                 320 


Leu Tyr His His Phe Ile Arg His Pro Ser Lys His Phe Glu Glu Asn 
                325                 330                 335     


Pro Ala Ile Ile Ser Asp Leu Thr Gly Thr Ser Met Trp Val Leu Val 
            340                 345                 350         


Lys Val Ser Lys Trp Thr Tyr Val Ala Tyr Asn Glu Ser Glu Lys Ile 
        355                 360                 365             


Tyr Phe Thr Phe Pro Leu Glu Asn His Arg Lys Ile Tyr Thr His Val 
    370                 375                 380                 


Tyr Cys Gln Ser Thr Met Leu Asp Thr Asn Ser Trp Ile Phe Ala Cys 
385                 390                 395                 400 


Ile Asn Ser Thr Ser Met Cys Leu Gln Gly Val Asp Leu Ser Trp Lys 
                405                 410                 415     


Ala Glu Leu Leu Pro Thr Ile Lys Tyr Leu Thr Leu Arg Leu Gln Asp 
            420                 425                 430         


Tyr Pro Ser Leu Ser His Leu Val Val Tyr Val Pro Ser Val Arg Gly 
        435                 440                 445             


Ser Lys Phe Val Val Asp Cys Glu Phe Phe Lys Lys Glu Lys Arg Tyr 
    450                 455                 460                 


Ile Gln Leu Pro Val Thr His Leu Phe Ser Phe Gly Leu Ser Ser Arg 
465                 470                 475                 480 


Lys Val Val Leu Asn Thr Asn Gly Leu Tyr Tyr Asn Leu Glu Leu Leu 
                485                 490                 495     


Asn Phe Gly Gln Ile Tyr Gln Ala Phe Lys Ile Asn Val Val Ser Lys 
            500                 505                 510         


Cys Ser Ala Val Lys Glu Glu Ile Thr Ser Ile Tyr Arg Leu His Ile 
        515                 520                 525             


Pro Trp Ser Tyr Glu Asp Ser Leu Thr Ile Ala Gln Ala Pro Ser Ser 
    530                 535                 540                 


Thr Glu Ile Ser Leu Lys Leu His Ile Ala Gln Pro Glu Asn Asn Thr 
545                 550                 555                 560 


His Val Ala Leu Phe Lys Met Tyr Thr Ser Ser Asp Cys Arg Tyr Glu 
                565                 570                 575     


Val Thr Val Lys Thr Ser Phe Ser Gln Ile Leu Gly Gln Val Val Arg 
            580                 585                 590         


Phe His Gly Gly Ala Leu Pro Ala Tyr Val Val Ser Asn Ile Leu Leu 
        595                 600                 605             


Ala Tyr Arg Gly Gln Leu Tyr Ser Leu Phe Ser Thr Gly Cys Cys Leu 
    610                 615                 620                 


Glu Tyr Ala Thr Met Leu Asp Lys Glu Ala Lys Pro Tyr Lys Val Asp 
625                 630                 635                 640 


Pro Phe Val Ile Ile Ile Lys Phe Leu Leu Gly Tyr Lys Trp Phe Lys 
                645                 650                 655     


Glu Leu Trp Asp Val Leu Leu Leu Pro Glu Leu Asp Ala Val Ile Leu 
            660                 665                 670         


Thr Cys Gln Ser Met Cys Phe Pro Leu Ile Ser Leu Ile Leu Phe Leu 
        675                 680                 685             


Phe Gly Thr Cys Thr Ala Tyr Trp Ser Gly Leu Leu Ser Ser Ala Ser 
    690                 695                 700                 


Val Arg Leu Leu Ser Ser Leu Trp Leu Ala Leu Lys Arg Pro Ser Glu 
705                 710                 715                 720 


Leu Pro Lys Asp Ile Lys Met Ile Ser Pro Asp Leu Pro Phe Leu Thr 
                725                 730                 735     


Ile Val Leu Ile Ile Val Ser Trp Thr Thr Cys Gly Ala Leu Ala Ile 
            740                 745                 750         


Leu Leu Ser Tyr Leu Tyr Tyr Val Phe Lys Val Val His Leu Gln Ala 
        755                 760                 765             


Ser Leu Thr Thr Phe Lys Asn Ser Gln Pro Val Asn Pro Lys His Ser 
    770                 775                 780                 


Arg Arg Ser Glu Lys Lys Ser Asn His His Lys Asp Ser Ser Ile His 
785                 790                 795                 800 


His Leu Arg Leu Ser Ala Asn Asp Ala Glu Asp Ser Leu Arg Met His 
                805                 810                 815     


Ser Thr Val Ile Asn Leu Leu Thr Trp Ile Val Leu Leu Ser Met Pro 
            820                 825                 830         


Ser Leu Ile Tyr Trp Leu Lys Asn Leu Arg Tyr Tyr Phe Lys Leu Asn 
        835                 840                 845             


Pro Asp Pro Cys Lys Pro Leu Ala Phe Ile Leu Ile Pro Thr Met Ala 
    850                 855                 860                 


Ile Leu Gly Asn Thr Tyr Thr Val Ser Ile Lys Ser Ser Lys Leu Leu 
865                 870                 875                 880 


Lys Thr Thr Ser Gln Phe Pro Leu Pro Leu Ala Val Gly Val Ile Ala 
                885                 890                 895     


Phe Gly Ser Ala His Leu Tyr Arg Leu Pro Cys Phe Val Phe Ile Pro 
            900                 905                 910         


Leu Leu Leu His Ala Leu Cys Asn Phe Met 
        915                 920         


<210>  5113
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  5113

Met Gly Phe His Leu Ile Thr Gln Leu Lys Gly Met Ser Val Val Leu 
1               5                   10                  15      


Val Leu Leu Pro Thr Leu Leu Leu Val Met Leu Thr Gly Ala Gln Arg 
            20                  25                  30          


Ala Cys Pro Lys Asn Cys Arg Cys Asp Gly Lys Ile Val Tyr Cys Glu 
        35                  40                  45              


Ser His Ala Phe Ala Asp Ile Pro Glu Asn Ile Ser Gly Gly Ser Gln 
    50                  55                  60                  


Gly Leu Ser Leu Arg Phe Asn Ser Ile Gln Lys Leu Lys Ser Asn Gln 
65                  70                  75                  80  


Phe Ala Gly Leu Asn Gln Leu Ile Trp Leu Tyr Leu Asp His Asn Tyr 
                85                  90                  95      


Ile Ser Ser Val Asp Glu Asp Ala Phe Gln Gly Ile Arg Arg Leu Lys 
            100                 105                 110         


Glu Leu Ile Leu Ser Ser Asn Lys Ile Thr Tyr Leu His Asn Lys Thr 
        115                 120                 125             


Phe His Pro Val Pro Asn Leu Arg Asn Leu Asp Leu Ser Tyr Asn Lys 
    130                 135                 140                 


Leu Gln Thr Leu Gln Ser Glu Gln Phe Lys Gly Leu Arg Lys Leu Ile 
145                 150                 155                 160 


Ile Leu His Leu Arg Ser Asn Ser Leu Lys Thr Val Pro Ile Arg Val 
                165                 170                 175     


Phe Gln Asp Cys Arg Asn Leu Asp Phe Leu Asp Leu Gly Tyr Asn Arg 
            180                 185                 190         


Leu Arg Ser Leu Ser Arg Asn Ala Phe Ala Gly Leu Leu Lys Leu Lys 
        195                 200                 205             


Glu Leu His Leu Glu His Asn Gln Phe Ser Lys Ile Asn Phe Ala His 
    210                 215                 220                 


Phe Pro Arg Leu Phe Asn Leu Arg Ser Ile Tyr Leu Gln Trp Asn Arg 
225                 230                 235                 240 


Ile Arg Ser Ile Ser Gln Gly Leu Thr Trp Thr Trp Ser Ser Leu His 
                245                 250                 255     


Asn Leu Asp Leu Ser Gly Asn Asp Ile Gln Gly Ile Glu Pro Gly Thr 
            260                 265                 270         


Phe Lys Cys Leu Pro Asn Leu Gln Lys Leu Asn Leu Asp Ser Asn Lys 
        275                 280                 285             


Leu Thr Asn Ile Ser Gln Glu Thr Val Asn Ala Trp Ile Ser Leu Ile 
    290                 295                 300                 


Ser Ile Thr Leu Ser Gly Asn Met Trp Glu Cys Ser Arg Ser Ile Cys 
305                 310                 315                 320 


Pro Leu Phe Tyr Trp Leu Lys Asn Phe Lys Gly Asn Lys Glu Ser Thr 
                325                 330                 335     


Met Ile Cys Ala Gly Pro Lys His Ile Gln Gly Glu Lys Val Ser Asp 
            340                 345                 350         


Ala Val Glu Thr Tyr Asn Ile Cys Ser Glu Val Gln Val Val Asn Thr 
        355                 360                 365             


Glu Arg Ser His Leu Val Pro Gln Thr Pro Gln Lys Pro Leu Ile Ile 
    370                 375                 380                 


Pro Arg Pro Thr Ile Phe Lys Pro Asp Val Thr Gln Ser Thr Phe Glu 
385                 390                 395                 400 


Thr Pro Ser Pro Ser Pro Gly Phe Gln Ile Pro Gly Ala Glu Gln Glu 
                405                 410                 415     


Tyr Glu His Val Ser Phe His Lys Ile Ile Ala Gly Ser Val Ala Leu 
            420                 425                 430         


Phe Leu Ser Val Ala Met Ile Leu Leu Val Ile Tyr Val Ser Trp Lys 
        435                 440                 445             


Arg Tyr Pro Ala Ser Met Lys Gln Leu Gln Gln His Ser Leu Met Lys 
    450                 455                 460                 


Arg Arg Arg Lys Lys Ala Arg Glu Ser Glu Arg Gln Met Asn Ser Pro 
465                 470                 475                 480 


Leu Gln Glu Tyr Tyr Val Asp Tyr Lys Pro Thr Asn Ser Glu Thr Met 
                485                 490                 495     


Asp Ile Ser Val Asn Gly Ser Gly Pro Cys Thr Tyr Thr Ile Ser Gly 
            500                 505                 510         


Ser Arg Glu Cys Glu Val 
        515             


<210>  5114
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  5114

Met Lys Val Gly Val Leu Trp Leu Ile Ser Phe Phe Thr Phe Thr Asp 
1               5                   10                  15      


Gly His Gly Gly Phe Leu Gly Lys Asn Asp Gly Ile Lys Thr Lys Lys 
            20                  25                  30          


Glu Leu Ile Val Asn Lys Lys Lys His Leu Gly Pro Val Glu Glu Tyr 
        35                  40                  45              


Gln Leu Leu Leu Gln Val Thr Tyr Arg Asp Ser Lys Glu Lys Arg Asp 
    50                  55                  60                  


Leu Arg Asn Phe Leu Lys Leu Leu Lys Pro Pro Leu Leu Trp Ser His 
65                  70                  75                  80  


Gly Leu Ile Arg Ile Ile Arg Ala Lys Ala Thr Thr Asp Cys Asn Ser 
                85                  90                  95      


Leu Asn Gly Val Leu Gln Cys Thr Cys Glu Asp Ser Tyr Thr Trp Phe 
            100                 105                 110         


Pro Pro Ser Cys Leu Asp Pro Gln Asn Cys Tyr Leu His Thr Ala Gly 
        115                 120                 125             


Ala Leu Pro Ser Cys Glu Cys His Leu Asn Asn Leu Ser Gln Ser Val 
    130                 135                 140                 


Asn Phe Cys Glu Arg Thr Lys Ile Trp Gly Thr Phe Lys Ile Asn Glu 
145                 150                 155                 160 


Arg Phe Thr Asn Asp Leu Leu Asn Ser Ser Ser Ala Ile Tyr Ser Lys 
                165                 170                 175     


Tyr Ala Asn Gly Ile Glu Ile Gln Leu Lys Lys Ala Tyr Glu Arg Ile 
            180                 185                 190         


Gln Gly Phe Glu Ser Val Gln Val Thr Gln Phe Arg Met Ser Leu Leu 
        195                 200                 205             


Ser Pro Lys Leu Glu Cys Asn Gly Thr Ile 
    210                 215             


<210>  5115
<211>  796
<212>  PRT
<213>  Homo sapiens

<400>  5115

Met Ile Pro Val Ala Glu Phe Lys Gln Phe Thr Glu Gln Gln Pro Ala 
1               5                   10                  15      


Phe Lys Val Leu Lys Pro Trp Trp Asp Val Leu Ala Glu Tyr Leu Thr 
            20                  25                  30          


Val Ala Met Leu Met Ile Gly Val Phe Gly Cys Thr Leu Gln Val Thr 
        35                  40                  45              


Gln Asp Lys Ile Ile Cys Leu Pro Asn His Glu Leu Gln Glu Asn Leu 
    50                  55                  60                  


Ser Glu Ala Pro Cys Gln Gln Leu Leu Pro Arg Gly Ile Pro Glu Gln 
65                  70                  75                  80  


Ile Gly Ala Leu Gln Glu Val Lys Gly Leu Lys Asn Asn Leu Asp Leu 
                85                  90                  95      


Gln Gln Tyr Ser Phe Ile Asn Gln Leu Cys Tyr Glu Thr Ala Leu His 
            100                 105                 110         


Trp Tyr Ala Lys Tyr Phe Pro Tyr Leu Val Val Ile His Thr Leu Ile 
        115                 120                 125             


Phe Met Val Cys Thr Ser Phe Trp Phe Lys Phe Pro Gly Thr Ser Ser 
    130                 135                 140                 


Lys Ile Glu His Phe Ile Ser Ile Leu Gly Lys Cys Phe Asp Ser Pro 
145                 150                 155                 160 


Trp Thr Thr Arg Ala Leu Ser Glu Val Ser Gly Glu Asn Gln Lys Gly 
                165                 170                 175     


Pro Ala Ala Thr Glu Arg Ala Ala Ala Thr Ile Val Ala Met Ala Gly 
            180                 185                 190         


Thr Gly Pro Gly Lys Ala Gly Glu Gly Glu Lys Glu Lys Val Leu Ala 
        195                 200                 205             


Glu Pro Glu Lys Val Val Thr Glu Pro Pro Val Val Thr Leu Leu Asp 
    210                 215                 220                 


Lys Lys Glu Gly Glu Gln Ala Lys Ala Leu Phe Glu Lys Val Lys Lys 
225                 230                 235                 240 


Phe Arg Met His Val Glu Glu Gly Asp Ile Leu Tyr Thr Met Tyr Ile 
                245                 250                 255     


Arg Gln Thr Val Leu Lys Val Cys Lys Phe Leu Ala Ile Leu Val Tyr 
            260                 265                 270         


Asn Leu Val Tyr Val Glu Lys Ile Ser Phe Leu Val Ala Cys Arg Val 
        275                 280                 285             


Glu Thr Ser Glu Val Thr Gly Tyr Ala Ser Phe Cys Cys Asn His Thr 
    290                 295                 300                 


Lys Ala His Leu Phe Ser Lys Leu Ala Phe Cys Tyr Ile Ser Phe Val 
305                 310                 315                 320 


Cys Ile Tyr Gly Leu Thr Cys Ile Tyr Thr Leu Tyr Trp Leu Phe His 
                325                 330                 335     


Arg Pro Leu Lys Glu Tyr Ser Phe Arg Ser Val Arg Glu Glu Thr Gly 
            340                 345                 350         


Met Gly Asp Ile Pro Asp Val Lys Asn Asp Phe Ala Phe Met Leu His 
        355                 360                 365             


Leu Ile Asp Gln Tyr Asp Ser Leu Tyr Ser Lys Arg Phe Ala Val Phe 
    370                 375                 380                 


Leu Ser Glu Val Ser Glu Ser Arg Leu Lys Gln Leu Asn Leu Asn His 
385                 390                 395                 400 


Glu Trp Thr Pro Glu Lys Leu Arg Gln Lys Leu Gln Arg Asn Ala Ala 
                405                 410                 415     


Gly Arg Leu Glu Leu Ala Leu Cys Met Leu Pro Gly Leu Pro Asp Thr 
            420                 425                 430         


Val Phe Glu Leu Ser Glu Val Glu Ser Leu Arg Leu Glu Ala Ile Cys 
        435                 440                 445             


Asp Ile Thr Phe Pro Pro Gly Leu Ser Gln Leu Val His Leu Gln Glu 
    450                 455                 460                 


Leu Ser Leu Leu His Ser Pro Ala Arg Leu Pro Phe Ser Leu Gln Val 
465                 470                 475                 480 


Phe Leu Arg Asp His Leu Lys Val Met Arg Val Lys Cys Glu Glu Leu 
                485                 490                 495     


Arg Glu Val Pro Leu Trp Val Phe Gly Leu Arg Gly Leu Glu Glu Leu 
            500                 505                 510         


His Leu Glu Gly Leu Phe Pro Gln Glu Leu Ala Arg Ala Ala Thr Leu 
        515                 520                 525             


Glu Ser Leu Arg Glu Leu Lys Gln Leu Lys Val Leu Ser Leu Arg Ser 
    530                 535                 540                 


Asn Ala Gly Lys Val Pro Ala Ser Val Thr Asp Val Ala Gly His Leu 
545                 550                 555                 560 


Gln Arg Leu Ser Leu His Asn Asp Gly Ala Arg Leu Val Ala Leu Asn 
                565                 570                 575     


Ser Leu Lys Lys Leu Ala Ala Leu Arg Glu Leu Glu Leu Val Ala Cys 
            580                 585                 590         


Gly Leu Glu Arg Ile Pro His Ala Val Phe Ser Leu Gly Ala Leu Gln 
        595                 600                 605             


Glu Leu Asp Leu Lys Asp Asn His Leu Arg Ser Ile Glu Glu Ile Leu 
    610                 615                 620                 


Ser Phe Gln His Cys Arg Lys Leu Val Thr Leu Arg Leu Trp His Asn 
625                 630                 635                 640 


Gln Ile Ala Tyr Val Pro Glu His Val Arg Lys Leu Arg Ser Leu Glu 
                645                 650                 655     


Gln Leu Tyr Leu Ser Tyr Asn Lys Leu Glu Thr Leu Pro Ser Gln Leu 
            660                 665                 670         


Gly Leu Cys Ser Gly Leu Arg Leu Leu Asp Val Ser His Asn Gly Leu 
        675                 680                 685             


His Ser Leu Pro Pro Glu Val Gly Leu Leu Gln Asn Leu Gln His Leu 
    690                 695                 700                 


Ala Leu Ser Tyr Asn Ala Leu Glu Ala Leu Pro Glu Glu Leu Phe Phe 
705                 710                 715                 720 


Cys Arg Lys Leu Arg Thr Leu Leu Leu Gly Asp Asn Gln Leu Ser Gln 
                725                 730                 735     


Leu Ser Pro His Val Gly Ala Leu Arg Ala Leu Ser Arg Leu Glu Leu 
            740                 745                 750         


Lys Gly Asn Arg Leu Glu Ala Leu Pro Glu Glu Leu Gly Asn Cys Gly 
        755                 760                 765             


Gly Leu Lys Lys Ala Gly Leu Leu Val Glu Asp Thr Leu Tyr Gln Gly 
    770                 775                 780                 


Leu Pro Ala Glu Val Arg Asp Lys Met Glu Glu Glu 
785                 790                 795     


<210>  5116
<211>  4012
<212>  PRT
<213>  Homo sapiens

<400>  5116

Met Gly Val Leu Lys Val Trp Leu Gly Leu Ala Leu Ala Leu Ala Glu 
1               5                   10                  15      


Phe Ala Val Leu Pro His His Ser Glu Gly Ala Cys Val Tyr Gln Asp 
            20                  25                  30          


Ser Leu Leu Ala Asp Ala Thr Ile Trp Lys Pro Asp Ser Cys Gln Ser 
        35                  40                  45              


Cys Arg Cys His Gly Asp Ile Val Ile Cys Lys Pro Ala Val Cys Arg 
    50                  55                  60                  


Asn Pro Gln Cys Ala Phe Glu Lys Gly Glu Val Leu Gln Ile Ala Ala 
65                  70                  75                  80  


Asn Gln Cys Cys Pro Glu Cys Val Leu Arg Thr Pro Gly Ser Cys His 
                85                  90                  95      


His Glu Lys Lys Ile His Glu His Gly Thr Glu Trp Ala Ser Ser Pro 
            100                 105                 110         


Cys Ser Val Cys Ser Cys Asn His Gly Glu Val Arg Cys Thr Pro Gln 
        115                 120                 125             


Pro Cys Pro Pro Leu Ser Cys Gly His Gln Glu Leu Ala Phe Ile Pro 
    130                 135                 140                 


Glu Gly Ser Cys Cys Pro Val Cys Val Gly Leu Gly Lys Pro Cys Ser 
145                 150                 155                 160 


Tyr Glu Gly His Val Phe Gln Asp Gly Glu Asp Trp Arg Leu Ser Arg 
                165                 170                 175     


Cys Ala Lys Cys Leu Cys Arg Asn Gly Val Ala Gln Cys Phe Thr Ala 
            180                 185                 190         


Gln Cys Gln Pro Leu Phe Cys Asn Gln Asp Glu Thr Val Val Arg Val 
        195                 200                 205             


Pro Gly Lys Cys Cys Pro Gln Cys Ser Ala Arg Ser Cys Ser Ala Ala 
    210                 215                 220                 


Gly Gln Val Tyr Glu His Gly Glu Gln Trp Ser Glu Asn Ala Cys Thr 
225                 230                 235                 240 


Thr Cys Ile Cys Asp Arg Gly Glu Val Arg Cys His Lys Gln Ala Cys 
                245                 250                 255     


Leu Pro Leu Arg Cys Gly Lys Gly Gln Ser Arg Ala Arg Arg His Gly 
            260                 265                 270         


Gln Cys Cys Glu Glu Cys Val Ser Pro Ala Gly Ser Cys Ser Tyr Asp 
        275                 280                 285             


Gly Val Val Arg Tyr Gln Asp Glu Met Trp Lys Gly Ser Ala Cys Glu 
    290                 295                 300                 


Phe Cys Met Cys Asp His Gly Gln Val Thr Cys Gln Thr Gly Glu Cys 
305                 310                 315                 320 


Ala Lys Val Glu Cys Ala Arg Asp Glu Glu Leu Ile His Leu Asp Gly 
                325                 330                 335     


Lys Cys Cys Pro Glu Cys Ile Ser Arg Asn Gly Tyr Cys Val Tyr Glu 
            340                 345                 350         


Glu Thr Gly Glu Phe Met Ser Ser Asn Ala Ser Glu Val Lys Arg Ile 
        355                 360                 365             


Pro Glu Gly Glu Lys Trp Glu Asp Gly Pro Cys Lys Val Cys Glu Cys 
    370                 375                 380                 


Arg Gly Ala Gln Val Thr Cys Tyr Glu Pro Ser Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Val Gly Thr Leu Ala Leu Glu Val Lys Gly Gln Cys Cys Pro Asp Cys 
                405                 410                 415     


Thr Ser Val His Cys His Pro Asp Cys Leu Thr Cys Ser Gln Ser Pro 
            420                 425                 430         


Asp His Cys Asp Leu Cys Gln Asp Pro Thr Lys Leu Leu Gln Asn Gly 
        435                 440                 445             


Trp Cys Val His Ser Cys Gly Leu Gly Phe Tyr Gln Ala Gly Ser Leu 
    450                 455                 460                 


Cys Leu Ala Cys Gln Pro Gln Cys Ser Thr Cys Thr Ser Gly Leu Glu 
465                 470                 475                 480 


Cys Ser Ser Cys Gln Pro Pro Leu Leu Met Arg His Gly Gln Cys Val 
                485                 490                 495     


Pro Thr Cys Gly Asp Gly Phe Tyr Gln Asp Arg His Ser Cys Ala Val 
            500                 505                 510         


Cys His Glu Ser Cys Ala Gly Cys Trp Gly Pro Thr Glu Lys His Cys 
        515                 520                 525             


Leu Ala Cys Arg Asp Pro Leu His Val Leu Arg Asp Gly Gly Cys Glu 
    530                 535                 540                 


Ser Ser Cys Gly Lys Gly Phe Tyr Asn Arg Gln Gly Thr Cys Ser Ala 
545                 550                 555                 560 


Cys Asp Gln Ser Cys Asp Ser Cys Gly Pro Ser Ser Pro Arg Cys Leu 
                565                 570                 575     


Thr Cys Thr Glu Lys Thr Val Leu His Asp Gly Lys Cys Met Ser Glu 
            580                 585                 590         


Cys Pro Gly Gly Tyr Tyr Ala Asp Ala Thr Gly Arg Cys Lys Val Cys 
        595                 600                 605             


His Asn Ser Cys Ala Ser Cys Ser Gly Pro Thr Pro Ser His Cys Thr 
    610                 615                 620                 


Ala Cys Ser Pro Pro Lys Ala Leu Arg Gln Gly His Cys Leu Pro Arg 
625                 630                 635                 640 


Cys Gly Glu Gly Phe Tyr Ser Asp His Gly Val Cys Lys Ala Cys His 
                645                 650                 655     


Ser Ser Cys Leu Ala Cys Met Gly Pro Ala Pro Ser His Cys Thr Gly 
            660                 665                 670         


Cys Lys Lys Pro Glu Glu Gly Leu Gln Val Glu Gln Leu Ser Asp Val 
        675                 680                 685             


Gly Ile Pro Ser Gly Glu Cys Leu Ala Gln Cys Arg Ala His Phe Tyr 
    690                 695                 700                 


Leu Glu Ser Thr Gly Ile Cys Glu Ala Cys His Gln Ser Cys Phe Arg 
705                 710                 715                 720 


Cys Ala Gly Lys Ser Pro His Asn Cys Thr Asp Cys Gly Pro Ser His 
                725                 730                 735     


Val Leu Leu Asp Gly Gln Cys Leu Ser Gln Cys Pro Asp Gly Tyr Phe 
            740                 745                 750         


His Gln Glu Gly Ser Cys Thr Glu Cys His Pro Thr Cys Arg Gln Cys 
        755                 760                 765             


His Gly Pro Leu Glu Ser Asp Cys Ile Ser Cys Tyr Pro His Ile Ser 
    770                 775                 780                 


Leu Thr Asn Gly Asn Cys Arg Thr Ser Cys Arg Glu Glu Gln Phe Leu 
785                 790                 795                 800 


Asn Leu Val Gly Tyr Cys Ala Asp Cys His His Leu Cys Gln His Cys 
                805                 810                 815     


Ala Ala Asp Leu His Asn Thr Gly Ser Ile Cys Leu Arg Cys Gln Asn 
            820                 825                 830         


Ala His Tyr Leu Leu Leu Gly Asp His Cys Val Pro Asp Cys Pro Ser 
        835                 840                 845             


Gly Tyr Tyr Ala Glu Arg Gly Ala Cys Lys Lys Cys His Ser Ser Cys 
    850                 855                 860                 


Arg Thr Cys Gln Gly Arg Gly Pro Phe Ser Cys Ser Ser Cys Asp Thr 
865                 870                 875                 880 


Asn Leu Val Leu Ser His Thr Gly Thr Cys Ser Thr Thr Cys Phe Pro 
                885                 890                 895     


Gly His Tyr Leu Asp Asp Asn His Val Cys Gln Pro Cys Asn Thr His 
            900                 905                 910         


Cys Gly Ser Cys Asp Ser Gln Ala Ser Cys Thr Ser Cys Arg Asp Pro 
        915                 920                 925             


Asn Lys Val Leu Leu Phe Gly Glu Cys Gln Tyr Glu Ser Cys Ala Pro 
    930                 935                 940                 


Gln Tyr Tyr Leu Asp Phe Ser Thr Asn Thr Cys Lys Glu Cys Asp Trp 
945                 950                 955                 960 


Ser Cys Ser Ala Cys Ser Gly Pro Leu Lys Thr Asp Cys Leu Gln Cys 
                965                 970                 975     


Met Asp Gly Tyr Val Leu Gln Asp Gly Ala Cys Val Glu Gln Cys Leu 
            980                 985                 990         


Ser Ser Phe Tyr Gln Asp Ser Gly  Leu Cys Lys Asn Cys  Asp Ser Tyr 
        995                 1000                 1005             


Cys Leu  Gln Cys Gln Gly Pro  His Glu Cys Thr Arg  Cys Lys Gly 
    1010                 1015                 1020             


Pro Phe  Leu Leu Leu Glu Ala  Gln Cys Val Gln Glu  Cys Gly Lys 
    1025                 1030                 1035             


Gly Tyr  Phe Ala Asp His Ala  Lys His Lys Cys Thr  Ala Cys Pro 
    1040                 1045                 1050             


Gln Gly  Cys Leu Gln Cys Ser  His Arg Asp Arg Cys  His Leu Cys 
    1055                 1060                 1065             


Asp His  Gly Phe Phe Leu Lys  Ser Gly Leu Cys Val  Tyr Asn Cys 
    1070                 1075                 1080             


Val Pro  Gly Phe Ser Val His  Thr Ser Asn Glu Thr  Cys Ser Gly 
    1085                 1090                 1095             


Lys Ile  His Thr Pro Ser Leu  His Val Asn Gly Ser  Leu Ile Leu 
    1100                 1105                 1110             


Pro Ile  Gly Ser Ile Lys Pro  Leu Asp Phe Ser Leu  Leu Asn Val 
    1115                 1120                 1125             


Gln Asp  Gln Glu Gly Arg Val  Glu Asp Leu Leu Phe  His Val Val 
    1130                 1135                 1140             


Ser Thr  Pro Thr Asn Gly Gln  Leu Val Leu Ser Arg  Asn Gly Lys 
    1145                 1150                 1155             


Glu Val  Gln Leu Asp Lys Ala  Gly Arg Phe Ser Trp  Lys Asp Val 
    1160                 1165                 1170             


Asn Glu  Lys Lys Val Arg Phe  Val His Ser Lys Glu  Lys Leu Arg 
    1175                 1180                 1185             


Lys Gly  Tyr Leu Phe Leu Lys  Ile Ser Asp Gln Gln  Phe Phe Ser 
    1190                 1195                 1200             


Glu Pro  Gln Leu Ile Asn Ile  Gln Ala Phe Ser Thr  Gln Ala Pro 
    1205                 1210                 1215             


Tyr Val  Leu Arg Asn Glu Val  Leu His Ile Ser Arg  Gly Glu Arg 
    1220                 1225                 1230             


Ala Thr  Ile Thr Thr Gln Met  Leu Asp Ile Arg Asp  Asp Asp Asn 
    1235                 1240                 1245             


Pro Gln  Asp Val Val Ile Glu  Ile Ile Asp Pro Pro  Leu His Gly 
    1250                 1255                 1260             


Gln Leu  Leu Gln Thr Leu Gln  Ser Pro Ala Thr Pro  Ile Tyr Gln 
    1265                 1270                 1275             


Phe Gln  Leu Asp Glu Leu Ser  Arg Gly Leu Leu His  Tyr Ala His 
    1280                 1285                 1290             


Asp Gly  Ser Asp Ser Thr Ser  Asp Val Ala Val Leu  Gln Ala Asn 
    1295                 1300                 1305             


Asp Gly  His Ser Phe His Asn  Ile Leu Phe Gln Val  Lys Thr Val 
    1310                 1315                 1320             


Pro Gln  Asn Asp Arg Gly Leu  Gln Leu Val Ala Asn  Ser Met Val 
    1325                 1330                 1335             


Trp Val  Pro Glu Gly Gly Met  Leu Gln Ile Thr Asn  Arg Ile Leu 
    1340                 1345                 1350             


Gln Ala  Glu Ala Pro Gly Ala  Ser Ala Glu Glu Ile  Ile Tyr Lys 
    1355                 1360                 1365             


Ile Thr  Gln Asp Tyr Pro Gln  Phe Gly Glu Val Val  Leu Leu Val 
    1370                 1375                 1380             


Asn Met  Pro Ala Asp Ser Pro  Ala Asp Glu Gly Gln  His Leu Pro 
    1385                 1390                 1395             


Asp Gly  Arg Thr Ala Thr Pro  Thr Ser Thr Phe Thr  Gln Gln Asp 
    1400                 1405                 1410             


Ile Asn  Glu Gly Ile Val Trp  Tyr Arg His Ser Gly  Ala Pro Ala 
    1415                 1420                 1425             


Gln Ser  Asp Ser Phe Arg Phe  Glu Val Ser Ser Ala  Ser Asn Ala 
    1430                 1435                 1440             


Gln Thr  Arg Leu Glu Ser His  Met Phe Asn Ile Ala  Ile Leu Pro 
    1445                 1450                 1455             


Gln Thr  Pro Glu Ala Pro Lys  Val Ser Leu Glu Ala  Ser Leu His 
    1460                 1465                 1470             


Met Thr  Ala Arg Glu Asp Gly  Leu Thr Val Ile Gln  Pro His Ser 
    1475                 1480                 1485             


Leu Ser  Phe Ile Asn Ser Glu  Lys Pro Ser Gly Lys  Ile Val Tyr 
    1490                 1495                 1500             


Asn Ile  Thr Leu Pro Leu His  Pro Asn Gln Gly Ile  Ile Glu His 
    1505                 1510                 1515             


Arg Asp  His Pro His Ser Pro  Ile Arg Tyr Phe Thr  Gln Glu Asp 
    1520                 1525                 1530             


Ile Asn  Gln Gly Lys Val Met  Tyr Arg Pro Pro Pro  Ala Ala Pro 
    1535                 1540                 1545             


His Leu  Gln Glu Leu Met Ala  Phe Ser Phe Ala Gly  Leu Pro Glu 
    1550                 1555                 1560             


Ser Val  Lys Phe His Phe Thr  Val Ser Asp Gly Glu  His Thr Ser 
    1565                 1570                 1575             


Pro Glu  Met Val Leu Thr Ile  His Leu Leu Pro Ser  Asp Gln Gln 
    1580                 1585                 1590             


Leu Pro  Val Phe Gln Val Thr  Ala Pro Arg Leu Ala  Val Ser Pro 
    1595                 1600                 1605             


Gly Gly  Ser Thr Ser Val Gly  Leu Gln Val Val Val  Arg Asp Ala 
    1610                 1615                 1620             


Glu Thr  Ala Pro Lys Glu Leu  Phe Phe Glu Leu Arg  Arg Pro Pro 
    1625                 1630                 1635             


Gln His  Gly Val Leu Leu Lys  His Thr Ala Glu Phe  Arg Arg Pro 
    1640                 1645                 1650             


Met Ala  Thr Gly Asp Thr Phe  Thr Tyr Glu Asp Val  Glu Lys Asn 
    1655                 1660                 1665             


Ala Leu  Gln Tyr Ile His Asp  Gly Ser Ser Thr Arg  Glu Asp Ser 
    1670                 1675                 1680             


Met Glu  Ile Ser Val Thr Asp  Gly Leu Thr Val Thr  Met Leu Glu 
    1685                 1690                 1695             


Val Arg  Val Glu Val Ser Leu  Ser Glu Asp Arg Gly  Pro Arg Leu 
    1700                 1705                 1710             


Ala Ala  Gly Ser Ser Leu Ser  Ile Thr Val Ala Ser  Lys Ser Thr 
    1715                 1720                 1725             


Ala Ile  Ile Thr Arg Ser His  Leu Ala Tyr Val Asp  Asp Ser Ser 
    1730                 1735                 1740             


Pro Asp  Pro Glu Ile Trp Ile  Gln Leu Asn Tyr Leu  Pro Ser Tyr 
    1745                 1750                 1755             


Gly Thr  Leu Leu Arg Ile Ser  Gly Ser Glu Val Glu  Glu Leu Ser 
    1760                 1765                 1770             


Glu Val  Ser Asn Phe Thr Met  Glu Asp Ile Asn Asn  Lys Lys Ile 
    1775                 1780                 1785             


Arg Tyr  Ser Ala Val Phe Glu  Thr Asp Gly His Leu  Val Thr Asp 
    1790                 1795                 1800             


Ser Phe  Tyr Phe Ser Val Ser  Asp Met Asp His Asn  His Leu Asp 
    1805                 1810                 1815             


Asn Gln  Ile Phe Thr Ile Met  Ile Thr Pro Ala Glu  Asn Pro Pro 
    1820                 1825                 1830             


Pro Val  Ile Ala Phe Ala Asp  Leu Ile Thr Val Asp  Glu Gly Gly 
    1835                 1840                 1845             


Arg Ala  Pro Leu Ser Phe His  His Phe Phe Ala Thr  Asp Asp Asp 
    1850                 1855                 1860             


Asp Asn  Leu Gln Arg Asp Ala  Ile Ile Lys Leu Ser  Ala Leu Pro 
    1865                 1870                 1875             


Lys Tyr  Gly Cys Ile Glu Asn  Thr Gly Thr Gly Asp  Arg Phe Gly 
    1880                 1885                 1890             


Pro Glu  Thr Ala Ser Asp Leu  Glu Ala Ser Phe Pro  Ile Gln Asp 
    1895                 1900                 1905             


Val Leu  Glu Asn Tyr Ile Tyr  Tyr Phe Gln Ser Val  His Glu Ser 
    1910                 1915                 1920             


Ile Glu  Pro Thr His Asp Ile  Phe Ser Phe Tyr Val  Ser Asp Gly 
    1925                 1930                 1935             


Thr Ser  Arg Ser Glu Ile His  Ser Ile Asn Ile Thr  Ile Glu Arg 
    1940                 1945                 1950             


Lys Asn  Asp Glu Pro Pro Arg  Met Thr Leu Gln Pro  Leu Arg Val 
    1955                 1960                 1965             


Gln Leu  Ser Ser Gly Val Val  Ile Ser Asn Ser Ser  Leu Ser Leu 
    1970                 1975                 1980             


Gln Asp  Leu Asp Thr Pro Asp  Asn Glu Leu Ile Phe  Val Leu Thr 
    1985                 1990                 1995             


Lys Lys  Pro Asp His Gly His  Val Leu Trp Arg Gln  Thr Ala Ser 
    2000                 2005                 2010             


Glu Pro  Leu Glu Asn Gly Arg  Val Leu Val Gln Gly  Ser Thr Phe 
    2015                 2020                 2025             


Thr Tyr  Gln Asp Ile Leu Ala  Gly Leu Val Gly Tyr  Val Pro Ser 
    2030                 2035                 2040             


Val Pro  Gly Met Val Val Asp  Glu Phe Gln Phe Ser  Leu Thr Asp 
    2045                 2050                 2055             


Gly Leu  His Val Asp Thr Gly  Arg Met Lys Ile Tyr  Thr Glu Leu 
    2060                 2065                 2070             


Pro Ala  Ser Asp Thr Pro His  Leu Ala Ile Asn Gln  Gly Leu Gln 
    2075                 2080                 2085             


Leu Ser  Ala Gly Ser Val Ala  Arg Ile Thr Glu Gln  His Leu Lys 
    2090                 2095                 2100             


Val Thr  Asp Ile Asp Ser Asp  Asp His Gln Val Met  Tyr Ile Met 
    2105                 2110                 2115             


Lys Glu  Asp Pro Gly Ala Gly  Arg Leu Gln Met Met  Lys His Gly 
    2120                 2125                 2130             


Asn Leu  Glu Gln Ile Ser Ile  Lys Gly Pro Ile Arg  Ser Phe Thr 
    2135                 2140                 2145             


Gln Ala  Asp Ile Ser Gln Gly  His Val Glu Tyr Ser  His Gly Thr 
    2150                 2155                 2160             


Gly Glu  Pro Gly Gly Ser Phe  Ala Phe Lys Phe Asp  Val Val Asp 
    2165                 2170                 2175             


Gly Glu  Gly Asn Arg Leu Ile  Asp Lys Ser Phe Ser  Ile Ser Ile 
    2180                 2185                 2190             


Leu Glu  Asp Lys Ser Pro Pro  Val Ile Thr Thr Asn  Lys Gly Leu 
    2195                 2200                 2205             


Val Leu  Asp Glu Asn Ser Val  Lys Lys Ile Thr Thr  Leu Gln Leu 
    2210                 2215                 2220             


Ser Ala  Thr Asp Gln Asp Ser  Gly Pro Thr Glu Leu  Ile Tyr Arg 
    2225                 2230                 2235             


Ile Thr  Arg Gln Pro Gln Leu  Gly His Leu Glu His  Ala Ala Ser 
    2240                 2245                 2250             


Pro Gly  Ile Gln Ile Ser Ser  Phe Thr Gln Ala Asp  Leu Thr Ser 
    2255                 2260                 2265             


Arg Asn  Val Gln Tyr Val His  Ser Ser Glu Ala Glu  Lys His Ser 
    2270                 2275                 2280             


Asp Ala  Phe Ser Phe Thr Leu  Ser Asp Gly Val Ser  Glu Val Thr 
    2285                 2290                 2295             


Gln Thr  Phe His Ile Thr Leu  His Pro Val Asp Asp  Ser Leu Pro 
    2300                 2305                 2310             


Val Val  Gln Asn Leu Gly Met  Arg Val Gln Glu Gly  Met Arg Lys 
    2315                 2320                 2325             


Thr Ile  Thr Glu Phe Glu Leu  Lys Ala Val Asp Ala  Asp Thr Glu 
    2330                 2335                 2340             


Ala Glu  Ser Val Thr Phe Thr  Ile Val Gln Pro Pro  Arg His Gly 
    2345                 2350                 2355             


Thr Ile  Glu Arg Thr Ser Asn  Gly Gln His Phe His  Leu Thr Ser 
    2360                 2365                 2370             


Thr Phe  Thr Met Lys Asp Ile  Tyr Gln Asn Arg Val  Ser Tyr Ser 
    2375                 2380                 2385             


His Asp  Gly Ser Asn Ser Leu  Lys Asp Arg Phe Thr  Phe Thr Val 
    2390                 2395                 2400             


Ser Asp  Gly Thr Asn Pro Phe  Phe Ile Ile Glu Glu  Gly Gly Lys 
    2405                 2410                 2415             


Glu Ile  Met Thr Ala Ala Pro  Gln Pro Phe Arg Val  Asp Ile Leu 
    2420                 2425                 2430             


Pro Val  Asp Asp Gly Thr Pro  Arg Ile Val Thr Asn  Leu Gly Leu 
    2435                 2440                 2445             


Gln Trp  Leu Glu Tyr Met Asp  Gly Lys Ala Thr Asn  Leu Ile Thr 
    2450                 2455                 2460             


Lys Lys  Glu Leu Leu Thr Met  Asp Pro Asp Thr Glu  Asp Ala Gln 
    2465                 2470                 2475             


Leu Val  Tyr Glu Ile Thr Thr  Gly Pro Lys His Gly  Phe Val Glu 
    2480                 2485                 2490             


Asn Lys  Leu Gln Pro Gly Arg  Ala Ala Ala Thr Phe  Thr Gln Glu 
    2495                 2500                 2505             


Asp Val  Asn Leu Gly Leu Ile  Arg Tyr Val Leu His  Lys Glu Lys 
    2510                 2515                 2520             


Ile Arg  Glu Met Met Asp Ser  Phe Gln Phe Leu Val  Lys Asp Ser 
    2525                 2530                 2535             


Lys Pro  Asn Val Val Ser Asp  Asn Val Phe His Ile  Gln Trp Ser 
    2540                 2545                 2550             


Leu Ile  Ser Phe Lys Tyr Thr  Ser Tyr Asn Val Ser  Glu Lys Ala 
    2555                 2560                 2565             


Gly Ser  Val Ser Val Thr Val  Gln Arg Thr Gly Asn  Leu Asn Gln 
    2570                 2575                 2580             


Tyr Ala  Ile Val Leu Cys Arg  Thr Glu Gln Gly Thr  Ala Ser Ser 
    2585                 2590                 2595             


Ser Ser  Arg Val Ser Ser Gln  Pro Gly Gln Gln Asp  Tyr Val Glu 
    2600                 2605                 2610             


Tyr Ala  Gly Gln Val Gln Phe  Asp Glu Arg Glu Asp  Thr Lys Ser 
    2615                 2620                 2625             


Cys Thr  Ile Val Ile Asn Asp  Asp Asp Val Phe Glu  Asn Val Glu 
    2630                 2635                 2640             


Ser Phe  Thr Val Glu Leu Ser  Met Pro Ala Tyr Ala  Leu Leu Gly 
    2645                 2650                 2655             


Glu Phe  Thr Gln Ala Lys Val  Ile Ile Asn Asp Thr  Glu Asp Glu 
    2660                 2665                 2670             


Pro Thr  Leu Glu Phe Asp Lys  Lys Ile Tyr Trp Val  Asn Glu Ser 
    2675                 2680                 2685             


Ala Gly  Phe Leu Phe Ala Pro  Ile Glu Arg Lys Gly  Asp Ala Ser 
    2690                 2695                 2700             


Ser Ile  Val Ser Ala Ile Cys  Tyr Thr Val Pro Lys  Ser Ala Met 
    2705                 2710                 2715             


Gly Ser  Ser Leu Tyr Ala Leu  Glu Ser Gly Ser Asp  Phe Lys Ser 
    2720                 2725                 2730             


Arg Gly  Met Ser Ala Ala Ser  Arg Val Ile Phe Gly  Pro Gly Val 
    2735                 2740                 2745             


Thr Met  Ser Thr Cys Asp Val  Met Leu Ile Asp Asp  Ser Glu Tyr 
    2750                 2755                 2760             


Glu Glu  Glu Glu Glu Phe Glu  Ile Ala Leu Ala Asp  Ala Ser Asp 
    2765                 2770                 2775             


Asn Ala  Arg Ile Gly Arg Val  Ala Thr Ala Lys Val  Leu Ile Ser 
    2780                 2785                 2790             


Gly Pro  Asn Asp Ala Ser Thr  Val Ser Leu Gly Asn  Thr Ala Phe 
    2795                 2800                 2805             


Thr Val  Ser Glu Asp Ala Gly  Thr Val Lys Ile Pro  Val Ile Arg 
    2810                 2815                 2820             


His Gly  Thr Asp Leu Ser Thr  Phe Ala Ser Val Trp  Cys Ala Thr 
    2825                 2830                 2835             


Arg Pro  Ser Asp Pro Ala Ser  Ala Thr Pro Gly Val  Asp Tyr Val 
    2840                 2845                 2850             


Pro Ser  Ser Arg Lys Val Glu  Phe Gly Pro Gly Val  Ile Glu Gln 
    2855                 2860                 2865             


Tyr Cys  Thr Leu Thr Ile Leu  Asp Asp Thr Gln Tyr  Pro Val Ile 
    2870                 2875                 2880             


Glu Gly  Leu Glu Thr Phe Val  Val Phe Leu Ser Ser  Ala Gln Gly 
    2885                 2890                 2895             


Ala Glu  Leu Thr Lys Pro Phe  Gln Ala Val Ile Ala  Ile Asn Asp 
    2900                 2905                 2910             


Thr Phe  Gln Asp Val Pro Ser  Met Gln Phe Ala Lys  Asp Leu Leu 
    2915                 2920                 2925             


Leu Val  Lys Glu Lys Glu Gly  Val Leu His Val Pro  Ile Thr Arg 
    2930                 2935                 2940             


Ser Gly  Asp Leu Ser Tyr Glu  Ser Ser Val Arg Cys  Tyr Thr Gln 
    2945                 2950                 2955             


Ser His  Ser Ala Gln Val Met  Glu Asp Phe Glu Glu  Arg Gln Asn 
    2960                 2965                 2970             


Ala Asp  Ser Ser Arg Ile Thr  Phe Leu Lys Gly Asp  Lys Val Lys 
    2975                 2980                 2985             


Asn Cys  Thr Val Tyr Ile His  Asp Asp Ser Met Phe  Glu Pro Glu 
    2990                 2995                 3000             


Glu Gln  Phe Arg Val Tyr Leu  Gly Leu Pro Leu Gly  Asn His Trp 
    3005                 3010                 3015             


Ser Gly  Ala Arg Ile Gly Lys  Asn Asn Met Ala Thr  Ile Thr Ile 
    3020                 3025                 3030             


Ser Asn  Asp Glu Asp Ala Pro  Thr Ile Glu Phe Glu  Glu Ala Ala 
    3035                 3040                 3045             


Tyr Gln  Val Arg Glu Pro Ala  Gly Pro Asp Ala Ile  Ala Ile Leu 
    3050                 3055                 3060             


Asn Ile  Lys Val Ile Arg Arg  Gly Asp Gln Asn Arg  Thr Ser Lys 
    3065                 3070                 3075             


Val Arg  Cys Ser Thr Arg Asp  Gly Ser Ala Gln Ser  Gly Val Asp 
    3080                 3085                 3090             


Tyr Tyr  Pro Lys Ser Arg Val  Leu Lys Phe Ser Pro  Gly Val Asp 
    3095                 3100                 3105             


His Ile  Phe Phe Lys Val Glu  Ile Leu Ser Asn Glu  Asp Arg Glu 
    3110                 3115                 3120             


Trp His  Glu Ser Phe Ser Leu  Val Leu Gly Pro Asp  Asp Pro Val 
    3125                 3130                 3135             


Glu Ala  Val Leu Gly Asp Val  Thr Thr Ala Thr Val  Thr Ile Leu 
    3140                 3145                 3150             


Asp Gln  Glu Ala Ala Gly Ser  Leu Ile Leu Pro Ala  Pro Pro Ile 
    3155                 3160                 3165             


Val Val  Thr Leu Ala Asp Tyr  Asp His Val Glu Glu  Val Thr Lys 
    3170                 3175                 3180             


Glu Gly  Val Lys Lys Ser Pro  Ser Pro Gly Tyr Pro  Leu Val Cys 
    3185                 3190                 3195             


Val Thr  Pro Cys Asp Pro His  Phe Pro Arg Tyr Ala  Val Met Lys 
    3200                 3205                 3210             


Glu Arg  Cys Ser Glu Ala Gly  Ile Asn Gln Thr Ser  Val Gln Phe 
    3215                 3220                 3225             


Ser Trp  Glu Val Ala Ala Pro  Thr Asp Gly Asn Gly  Ala Arg Ser 
    3230                 3235                 3240             


Pro Phe  Glu Thr Ile Thr Asp  Asn Thr Pro Phe Thr  Ser Val Asn 
    3245                 3250                 3255             


His Met  Val Leu Asp Ser Ile  Tyr Phe Ser Arg Arg  Phe His Val 
    3260                 3265                 3270             


Arg Cys  Val Ala Lys Ala Val  Asp Lys Val Gly His  Val Gly Thr 
    3275                 3280                 3285             


Pro Leu  Arg Ser Asn Ile Val  Thr Ile Gly Thr Asp  Ser Ala Ile 
    3290                 3295                 3300             


Cys His  Thr Pro Val Val Ala  Gly Thr Ser Arg Gly  Phe Gln Ala 
    3305                 3310                 3315             


Gln Ser  Phe Ile Ala Thr Leu  Lys Tyr Leu Asp Val  Lys His Lys 
    3320                 3325                 3330             


Glu His  Pro Asn Arg Ile His  Ile Ser Val Gln Ile  Pro His Gln 
    3335                 3340                 3345             


Asp Gly  Met Leu Pro Leu Ile  Ser Thr Met Pro Leu  His Asn Leu 
    3350                 3355                 3360             


His Phe  Leu Leu Ser Glu Ser  Ile Tyr Arg His Gln  His Val Cys 
    3365                 3370                 3375             


Ser Asn  Leu Val Thr Thr Tyr  Asp Leu Arg Gly Ile  Ser Glu Ala 
    3380                 3385                 3390             


Gly Phe  Leu Asp Asp Val Val  Tyr Asp Ser Thr Ala  Leu Gly Pro 
    3395                 3400                 3405             


Gly Tyr  Asp Arg Pro Phe Gln  Phe Asp Pro Ser Val  Arg Glu Pro 
    3410                 3415                 3420             


Lys Thr  Ile Gln Leu Tyr Lys  His Leu Asn Leu Lys  Ser Cys Val 
    3425                 3430                 3435             


Trp Thr  Phe Asp Ala Tyr Tyr  Asp Met Thr Glu Leu  Ile Asp Val 
    3440                 3445                 3450             


Cys Gly  Gly Ser Val Thr Ala  Asp Phe Gln Val Arg  Asp Ser Ala 
    3455                 3460                 3465             


Gln Ser  Phe Leu Thr Val His  Val Pro Leu Tyr Val  Ser Tyr Ile 
    3470                 3475                 3480             


Tyr Val  Thr Ala Pro Arg Gly  Trp Ala Ser Leu Glu  His His Thr 
    3485                 3490                 3495             


Glu Met  Glu Phe Ser Phe Phe  Tyr Asp Thr Val Leu  Trp Arg Thr 
    3500                 3505                 3510             


Gly Ile  Gln Thr Asp Ser Val  Leu Ser Ala Arg Leu  Gln Ile Ile 
    3515                 3520                 3525             


Arg Ile  Tyr Ile Arg Glu Asp  Gly Arg Leu Val Ile  Glu Phe Lys 
    3530                 3535                 3540             


Thr His  Ala Lys Phe Arg Gly  Gln Phe Val Met Glu  His His Thr 
    3545                 3550                 3555             


Leu Pro  Glu Val Lys Ser Phe  Val Leu Thr Pro Asp  His Leu Gly 
    3560                 3565                 3570             


Gly Ile  Glu Phe Asp Leu Gln  Leu Leu Trp Ser Ala  Gln Thr Phe 
    3575                 3580                 3585             


Asp Ser  Pro His Gln Leu Trp  Arg Ala Thr Ser Ser  Tyr Asn Arg 
    3590                 3595                 3600             


Lys Asp  Tyr Ser Gly Glu Tyr  Thr Ile Tyr Leu Ile  Pro Cys Thr 
    3605                 3610                 3615             


Val Gln  Pro Thr Gln Pro Trp  Val Asp Pro Gly Glu  Lys Pro Leu 
    3620                 3625                 3630             


Ala Cys  Thr Ala His Ala Pro  Glu Arg Phe Leu Ile  Pro Ile Ala 
    3635                 3640                 3645             


Phe Gln  Gln Thr Asn Arg Pro  Val Pro Val Val Tyr  Ser Leu Asn 
    3650                 3655                 3660             


Thr Glu  Phe Gln Leu Cys Asn  Asn Glu Lys Val Phe  Leu Met Asp 
    3665                 3670                 3675             


Pro Asn  Thr Ser Asp Met Ser  Leu Ala Glu Met Asp  Tyr Lys Gly 
    3680                 3685                 3690             


Ala Phe  Ser Lys Gly Gln Ile  Leu Tyr Gly Arg Val  Leu Trp Asn 
    3695                 3700                 3705             


Pro Glu  Gln Asn Leu Asn Ser  Ala Tyr Lys Leu Gln  Leu Glu Lys 
    3710                 3715                 3720             


Val Tyr  Leu Cys Thr Gly Lys  Asp Gly Tyr Val Pro  Phe Phe Asp 
    3725                 3730                 3735             


Pro Thr  Gly Thr Ile Tyr Asn  Glu Gly Pro Gln Tyr  Gly Cys Ile 
    3740                 3745                 3750             


Gln Pro  Asn Lys His Leu Lys  His Arg Phe Leu Leu  Leu Asp Arg 
    3755                 3760                 3765             


Asn Gln  Pro Glu Val Thr Asp  Lys Tyr Phe His Asp  Val Pro Phe 
    3770                 3775                 3780             


Glu Ala  His Phe Ala Ser Glu  Leu Pro Asp Phe His  Val Val Ser 
    3785                 3790                 3795             


Asn Met  Pro Gly Val Asp Gly  Phe Thr Leu Lys Val  Asp Ala Leu 
    3800                 3805                 3810             


Tyr Lys  Val Glu Ala Gly His  Gln Trp Tyr Leu Gln  Val Ile Tyr 
    3815                 3820                 3825             


Ile Ile  Gly Pro Asp Thr Ile  Ser Gly Pro Arg Val  Gln Arg Ser 
    3830                 3835                 3840             


Leu Thr  Ala Pro Leu Arg Arg  Asn Arg Arg Asp Leu  Val Glu Pro 
    3845                 3850                 3855             


Asp Gly  Gln Leu Ile Leu Asp  Asp Ser Leu Ile Tyr  Asp Asn Glu 
    3860                 3865                 3870             


Gly Asp  Gln Val Lys Asn Gly  Thr Asn Met Lys Ser  Leu Asn Leu 
    3875                 3880                 3885             


Glu Met  Gln Glu Leu Ala Val  Ala Ala Ser Leu Ser  Gln Thr Gly 
    3890                 3895                 3900             


Ala Ser  Ile Gly Ser Ala Leu  Ala Ala Ile Met Leu  Leu Leu Leu 
    3905                 3910                 3915             


Val Phe  Leu Val Ala Cys Phe  Ile Asn Arg Lys Cys  Gln Lys Gln 
    3920                 3925                 3930             


Arg Lys  Lys Lys Pro Ala Glu  Asp Ile Leu Glu Glu  Tyr Pro Leu 
    3935                 3940                 3945             


Asn Thr  Lys Val Glu Val Pro  Lys Arg His Pro Asp  Arg Val Glu 
    3950                 3955                 3960             


Lys Asn  Val Asn Arg His Tyr  Cys Thr Val Arg Asn  Val Asn Ile 
    3965                 3970                 3975             


Leu Ser  Glu Pro Glu Ala Ala  Tyr Thr Phe Lys Gly  Ala Lys Val 
    3980                 3985                 3990             


Lys Arg  Leu Asn Leu Glu Val  Arg Val His Asn Asn  Leu Gln Asp 
    3995                 4000                 4005             


Gly Thr  Glu Val 
    4010         


<210>  5117
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  5117

Met Val Ser Lys Ala Leu Leu Arg Leu Val Ser Ala Val Asn Arg Arg 
1               5                   10                  15      


Arg Met Lys Leu Leu Leu Gly Ile Ala Leu Leu Ala Tyr Val Ala Ser 
            20                  25                  30          


Val Trp Gly Asn Phe Val Asn Met Arg Ser Ile Gln Glu Asn Gly Glu 
        35                  40                  45              


Leu Lys Ile Glu Ser Lys Ile Glu Glu Met Val Glu Pro Leu Arg Glu 
    50                  55                  60                  


Lys Ile Arg Asp Leu Glu Lys Ser Phe Thr Gln Lys Tyr Pro Pro Val 
65                  70                  75                  80  


Lys Phe Leu Ser Glu Lys Asp Arg Lys Arg Ile Leu Ile Thr Gly Gly 
                85                  90                  95      


Ala Gly Phe Val Gly Ser His Leu Thr Asp Lys Leu Met Met Asp Gly 
            100                 105                 110         


His Glu Val Thr Val Val Asp Asn Phe Phe Thr Gly Arg Lys Arg Asn 
        115                 120                 125             


Val Glu His Trp Ile Gly His Glu Asn Phe Glu Leu Ile Asn His Asp 
    130                 135                 140                 


Val Val Glu Pro Leu Tyr Ile Glu Val Asp Gln Ile Tyr His Leu Ala 
145                 150                 155                 160 


Ser Pro Ala Ser Pro Pro Asn Tyr Met Tyr Asn Pro Ile Lys Thr Leu 
                165                 170                 175     


Lys Thr Asn Thr Ile Gly Thr Leu Asn Met Leu Gly Leu Ala Lys Arg 
            180                 185                 190         


Val Gly Ala Arg Leu Leu Leu Ala Ser Thr Ser Glu Val Tyr Gly Asp 
        195                 200                 205             


Pro Glu Val His Pro Gln Ser Glu Asp Tyr Trp Gly His Val Asn Pro 
    210                 215                 220                 


Ile Gly Pro Arg Ala Cys Tyr Asp Glu Gly Lys Arg Val Ala Glu Thr 
225                 230                 235                 240 


Met Cys Tyr Ala Tyr Met Lys Gln Glu Gly Val Glu Val Arg Val Ala 
                245                 250                 255     


Arg Ile Phe Asn Thr Phe Gly Pro Arg Met His Met Asn Asp Gly Arg 
            260                 265                 270         


Val Val Ser Asn Phe Ile Leu Gln Ala Leu Gln Gly Glu Pro Leu Thr 
        275                 280                 285             


Val Tyr Gly Ser Gly Ser Gln Thr Arg Ala Phe Gln Tyr Val Ser Asp 
    290                 295                 300                 


Leu Val Asn Gly Leu Val Ala Leu Met Asn Ser Asn Val Ser Ser Pro 
305                 310                 315                 320 


Val Asn Leu Gly Asn Pro Glu Glu His Thr Ile Leu Glu Phe Ala Gln 
                325                 330                 335     


Leu Ile Lys Asn Leu Val Gly Ser Gly Ser Glu Ile Gln Phe Leu Ser 
            340                 345                 350         


Glu Ala Gln Asp Asp Pro Gln Lys Arg Lys Pro Asp Ile Lys Lys Ala 
        355                 360                 365             


Lys Leu Met Leu Gly Trp Glu Pro Val Val Pro Leu Glu Glu Gly Leu 
    370                 375                 380                 


Asn Lys Ala Ile His Tyr Phe Arg Lys Glu Leu Glu Tyr Gln Ala Asn 
385                 390                 395                 400 


Asn Gln Tyr Ile Pro Lys Pro Lys Pro Ala Arg Ile Lys Lys Gly Arg 
                405                 410                 415     


Thr Arg His Ser 
            420 


<210>  5118
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  5118

Met Glu Ala Glu Gly Leu Asp Trp Leu Leu Val Pro Leu His Gln Leu 
1               5                   10                  15      


Val Ser Trp Gly Ala Ala Ala Ala Met Val Phe Gly Gly Val Val Pro 
            20                  25                  30          


Tyr Val Pro Gln Tyr Arg Asp Ile Arg Arg Thr Gln Asn Ala Asp Gly 
        35                  40                  45              


Phe Ser Thr Tyr Val Cys Leu Val Leu Leu Val Ala Asn Ile Leu Arg 
    50                  55                  60                  


Ile Leu Phe Trp Phe Gly Arg Arg Phe Glu Ser Pro Leu Leu Trp Gln 
65                  70                  75                  80  


Ser Ala Ile Met Ile Leu Thr Met Leu Leu Met Leu Lys Leu Cys Thr 
                85                  90                  95      


Glu Val Arg Val Ala Asn Glu Leu Asn Ala Arg Arg Arg Ser Phe Thr 
            100                 105                 110         


Ala Ala Asp Ser Lys Asp Glu Glu Val Lys Val Ala Pro Arg Arg Ser 
        115                 120                 125             


Phe Leu Asp Phe Asp Pro His His Phe Trp Gln Trp Ser Ser Phe Ser 
    130                 135                 140                 


Asp Tyr Val Gln Cys Val Leu Ala Phe Thr Gly Val Ala Gly Tyr Ile 
145                 150                 155                 160 


Thr Tyr Leu Ser Ile Asp Ser Ala Leu Phe Val Glu Thr Leu Gly Phe 
                165                 170                 175     


Leu Ala Val Leu Thr Glu Ala Met Leu Gly Val Pro Gln Leu Tyr Arg 
            180                 185                 190         


Asn His Arg His Gln Ser Thr Glu Gly Met Ser Ile Lys Met Val Leu 
        195                 200                 205             


Met Trp Thr Ser Gly Asp Ala Phe Lys Thr Ala Tyr Phe Leu Leu Lys 
    210                 215                 220                 


Gly Ala Pro Leu Gln Phe Ser Val Cys Gly Leu Leu Gln Val Leu Val 
225                 230                 235                 240 


Asp Leu Ala Ile Leu Gly Gln Ala Tyr Ala Phe Ala Arg His Pro Gln 
                245                 250                 255     


Lys Pro Ala Pro His Ala Val His Pro Thr Gly Thr Lys Ala Leu 
            260                 265                 270     


<210>  5119
<211>  699
<212>  PRT
<213>  Homo sapiens

<400>  5119

Met Pro Ser Leu Trp Arg Glu Ile Leu Leu Glu Ser Leu Leu Gly Cys 
1               5                   10                  15      


Val Ser Trp Ser Leu Tyr His Asp Leu Gly Pro Met Ile Tyr Tyr Phe 
            20                  25                  30          


Pro Leu Gln Thr Leu Glu Leu Thr Gly Leu Glu Gly Phe Ser Ile Ala 
        35                  40                  45              


Phe Leu Ser Pro Ile Phe Leu Thr Ile Thr Pro Phe Trp Lys Leu Val 
    50                  55                  60                  


Asn Lys Lys Trp Met Leu Thr Leu Leu Arg Ile Ile Thr Ile Gly Ser 
65                  70                  75                  80  


Ile Ala Ser Phe Gln Ala Pro Asn Ala Lys Leu Arg Leu Met Val Leu 
                85                  90                  95      


Ala Leu Gly Val Ser Ser Ser Leu Ile Val Gln Ala Val Thr Trp Trp 
            100                 105                 110         


Ser Gly Ser His Leu Gln Arg Tyr Leu Arg Ile Trp Gly Phe Ile Leu 
        115                 120                 125             


Gly Gln Ile Val Leu Val Val Leu Arg Ile Trp Tyr Thr Ser Leu Asn 
    130                 135                 140                 


Pro Ile Trp Ser Tyr Gln Met Ser Asn Lys Val Ile Leu Thr Leu Ser 
145                 150                 155                 160 


Ala Ile Ala Thr Leu Asp Arg Ile Gly Thr Asp Gly Asp Cys Ser Lys 
                165                 170                 175     


Pro Glu Glu Lys Lys Thr Gly Glu Val Ala Thr Gly Met Ala Ser Arg 
            180                 185                 190         


Pro Asn Trp Leu Leu Ala Gly Ala Ala Phe Gly Ser Leu Val Phe Leu 
        195                 200                 205             


Thr His Trp Val Phe Gly Glu Val Ser Leu Val Ser Arg Trp Ala Val 
    210                 215                 220                 


Ser Gly His Pro His Pro Gly Pro Asp Pro Asn Pro Phe Gly Gly Ala 
225                 230                 235                 240 


Val Leu Leu Cys Leu Ala Ser Gly Leu Met Leu Pro Ser Cys Leu Trp 
                245                 250                 255     


Phe Arg Gly Thr Gly Leu Ile Trp Trp Val Thr Gly Thr Ala Ser Ala 
            260                 265                 270         


Ala Gly Leu Leu Tyr Leu His Thr Trp Ala Ala Ala Val Ser Gly Cys 
        275                 280                 285             


Val Phe Ala Ile Phe Thr Ala Ser Met Trp Pro Gln Thr Leu Gly His 
    290                 295                 300                 


Leu Ile Asn Ser Gly Thr Asn Pro Gly Lys Thr Met Thr Ile Ala Met 
305                 310                 315                 320 


Ile Phe Tyr Leu Leu Glu Ile Phe Phe Cys Ala Trp Cys Thr Ala Phe 
                325                 330                 335     


Lys Phe Val Pro Gly Gly Val Tyr Ala Arg Glu Arg Ser Asp Val Leu 
            340                 345                 350         


Leu Gly Thr Met Met Leu Ile Ile Gly Leu Asn Met Leu Phe Gly Pro 
        355                 360                 365             


Lys Lys Asn Leu Asp Leu Leu Leu Gln Thr Lys Asn Ser Ser Lys Val 
    370                 375                 380                 


Leu Phe Arg Lys Ser Glu Lys Tyr Met Lys Leu Phe Leu Trp Leu Leu 
385                 390                 395                 400 


Val Gly Val Gly Leu Leu Gly Leu Gly Leu Arg His Lys Ala Tyr Glu 
                405                 410                 415     


Arg Lys Leu Gly Lys Val Ala Pro Thr Lys Glu Val Ser Ala Ala Ile 
            420                 425                 430         


Trp Pro Phe Arg Phe Gly Tyr Asp Asn Glu Gly Trp Ser Ser Leu Glu 
        435                 440                 445             


Arg Ser Ala His Leu Leu Asn Glu Thr Gly Ala Asp Phe Ile Thr Ile 
    450                 455                 460                 


Leu Glu Ser Asp Ala Ser Lys Pro Tyr Met Gly Asn Asn Asp Leu Thr 
465                 470                 475                 480 


Met Trp Leu Gly Glu Lys Leu Gly Phe Tyr Thr Asp Phe Gly Pro Ser 
                485                 490                 495     


Thr Arg Tyr His Thr Trp Gly Ile Met Ala Leu Ser Arg Tyr Pro Ile 
            500                 505                 510         


Val Lys Ser Glu His His Leu Leu Pro Ser Pro Glu Gly Glu Ile Ala 
        515                 520                 525             


Pro Ala Ile Thr Leu Thr Val Asn Ile Ser Gly Lys Leu Val Asp Phe 
    530                 535                 540                 


Val Val Thr His Phe Gly Asn His Glu Asp Asp Leu Asp Arg Lys Leu 
545                 550                 555                 560 


Gln Ala Ile Ala Val Ser Lys Leu Leu Lys Ser Ser Ser Asn Gln Val 
                565                 570                 575     


Ile Phe Leu Gly Tyr Ile Thr Ser Ala Pro Gly Ser Arg Asp Tyr Leu 
            580                 585                 590         


Gln Leu Thr Glu His Gly Asn Val Lys Asp Ile Asp Ser Thr Asp His 
        595                 600                 605             


Asp Arg Trp Cys Glu Tyr Ile Met Tyr Arg Gly Leu Ile Arg Leu Gly 
    610                 615                 620                 


Tyr Ala Arg Ile Ser His Ala Glu Leu Ser Asp Ser Glu Ile Gln Met 
625                 630                 635                 640 


Ala Lys Phe Arg Ile Pro Asp Asp Pro Thr Asn Tyr Arg Asp Asn Gln 
                645                 650                 655     


Lys Val Val Ile Asp His Arg Glu Val Ser Glu Lys Ile His Phe Asn 
            660                 665                 670         


Pro Arg Phe Gly Ser Tyr Lys Glu Gly His Asn Tyr Glu Asn Asn His 
        675                 680                 685             


His Phe His Met Asn Thr Pro Lys Tyr Phe Leu 
    690                 695                 


<210>  5120
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  5120

Met Arg Thr Gln Val Tyr Glu Gly Leu Cys Lys Asn Tyr Phe Ser Leu 
1               5                   10                  15      


Ala Val Leu Gln Arg Asp Arg Ile Lys Leu Leu Phe Phe Asp Ile Leu 
            20                  25                  30          


Val Phe Leu Ser Val Phe Leu Leu Phe Leu Leu Phe Leu Val Asp Ile 
        35                  40                  45              


Met Ala Asn Asn Thr Thr Ser Leu Gly Ser Pro Trp Pro Glu Asn Phe 
    50                  55                  60                  


Trp Glu Asp Leu Ile Met Ser Phe Thr Val Ser Met Ala Ile Gly Leu 
65                  70                  75                  80  


Val Leu Gly Gly Phe Ile Trp Ala Val Phe Ile Cys Leu Ser Arg Arg 
                85                  90                  95      


Arg Arg Ala Ser Ala Pro Ile Ser Gln Trp Ser Ser Ser Arg Arg Ser 
            100                 105                 110         


Arg Ser Ser Tyr Thr His Gly Leu Asn Arg Thr Gly Phe Tyr Arg His 
        115                 120                 125             


Ser Gly Cys Glu Arg Arg Ser Asn Leu Ser Leu Ala Ser Leu Thr Phe 
    130                 135                 140                 


Gln Arg Gln Ala Ser Leu Glu Gln Ala Asn Ser Phe Pro Arg Lys Ser 
145                 150                 155                 160 


Ser Phe Arg Ala Ser Thr Phe His Pro Phe Leu Gln Cys Pro Pro Leu 
                165                 170                 175     


Pro Val Glu Thr Glu Ser Gln Leu Val Thr Leu Pro Ser Ser Asn Ile 
            180                 185                 190         


Ser Pro Thr Ile Ser Thr Ser His Ser Leu Ser Arg Pro Asp Tyr Trp 
        195                 200                 205             


Ser Ser Asn Ser Leu Arg Val Gly Leu Ser Thr Pro Pro Pro Pro Ala 
    210                 215                 220                 


Tyr Glu Ser Ile Ile Lys Ala Phe Pro Asp Ser 
225                 230                 235 


<210>  5121
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  5121

Met Ser Ala Ala Arg Pro Gln Phe Ser Ile Asp Asp Ala Phe Glu Leu 
1               5                   10                  15      


Ser Leu Glu Asp Gly Gly Pro Gly Pro Glu Ser Ser Gly Val Ala Arg 
            20                  25                  30          


Phe Gly Pro Leu His Phe Glu Arg Arg Ala Arg Phe Glu Val Ala Asp 
        35                  40                  45              


Glu Asp Lys Gln Ser Arg Leu Arg Tyr Gln Asn Leu Glu Asn Asp Glu 
    50                  55                  60                  


Asp Gly Ala Gln Ala Ser Pro Glu Pro Asp Gly Gly Val Gly Thr Arg 
65                  70                  75                  80  


Asp Ser Ser Arg Thr Ser Ile Arg Ser Ser Gln Trp Ser Phe Ser Thr 
                85                  90                  95      


Ile Ser Ser Ser Thr Gln Arg Ser Tyr Asn Thr Cys Cys Ser Trp Thr 
            100                 105                 110         


Gln His Pro Leu Ile Gln Lys Asn Arg Arg Val Val Leu Ala Ser Phe 
        115                 120                 125             


Leu Leu Leu Leu Leu Gly Leu Val Leu Ile Leu Val Gly Val Gly Leu 
    130                 135                 140                 


Glu Ala Thr Pro Ser Pro Gly Val Ser Ser Ala Ile Phe Phe Val Pro 
145                 150                 155                 160 


Gly Phe Leu Leu Leu Val Pro Gly Val Tyr His Val Ile Phe Ile Tyr 
                165                 170                 175     


Cys Ala Val Lys Gly His Arg Gly Phe Gln Phe Phe Tyr Leu Pro Tyr 
            180                 185                 190         


Phe Glu Lys 
        195 


<210>  5122
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  5122

Met Ser Ala Ala Arg Pro Gln Phe Ser Ile Asp Asp Ala Phe Glu Leu 
1               5                   10                  15      


Ser Leu Glu Asp Gly Gly Pro Gly Pro Glu Ser Ser Gly Val Ala Arg 
            20                  25                  30          


Phe Gly Pro Leu His Phe Glu Arg Arg Ala Arg Phe Glu Val Ala Asp 
        35                  40                  45              


Glu Asp Lys Gln Ser Arg Leu Arg Tyr Gln Asn Leu Glu Asn Asp Glu 
    50                  55                  60                  


Asp Gly Ala Gln Ala Ser Pro Glu Pro Asp Gly Gly Val Gly Thr Arg 
65                  70                  75                  80  


Asp Ser Ser Arg Thr Ser Ile Arg Ser Ser Gln Trp Ser Phe Ser Thr 
                85                  90                  95      


Ile Ser Ser Ser Thr Gln Arg Ser Tyr Asn Thr Cys Cys Ser Trp Thr 
            100                 105                 110         


Gln His Pro Leu Ile Gln Lys Asn Arg Arg Val Val Leu Ala Ser Phe 
        115                 120                 125             


Leu Leu Leu Leu Leu Gly Leu Gly Val Ser Ser Ala Ile Phe Phe Val 
    130                 135                 140                 


Pro Gly Phe Leu Leu Leu Val Pro Gly Val Tyr His Val Ile Phe Ile 
145                 150                 155                 160 


Tyr Cys Ala Val Lys Gly His Arg Gly Phe Gln Phe Phe Tyr Leu Pro 
                165                 170                 175     


Tyr Phe Glu Lys 
            180 


<210>  5123
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  5123

Met Ala Thr Ala Ala Gly Ala Thr Tyr Phe Gln Arg Gly Ser Leu Phe 
1               5                   10                  15      


Trp Phe Thr Val Ile Thr Leu Ser Phe Gly Tyr Tyr Thr Trp Val Val 
            20                  25                  30          


Phe Trp Pro Gln Ser Ile Pro Tyr Gln Asn Leu Gly Pro Leu Gly Pro 
        35                  40                  45              


Phe Thr Gln Tyr Leu Val Asp His His His Thr Leu Leu Cys Asn Gly 
    50                  55                  60                  


Tyr Trp Leu Ala Trp Leu Ile His Val Gly Glu Ser Leu Tyr Ala Ile 
65                  70                  75                  80  


Val Leu Cys Lys His Lys Gly Ile Thr Ser Gly Arg Ala Gln Leu Leu 
                85                  90                  95      


Trp Phe Leu Gln Thr Phe Phe Phe Gly Ile Ala Ser Leu Thr Ile Leu 
            100                 105                 110         


Ile Ala Tyr Lys Arg Lys Arg Gln Lys Gln Thr 
        115                 120             


<210>  5124
<211>  1342
<212>  PRT
<213>  Homo sapiens

<400>  5124

Met Lys Arg Ile Phe Ser Leu Leu Glu Lys Thr Trp Leu Gly Ala Pro 
1               5                   10                  15      


Ile Gln Phe Ala Trp Gln Lys Thr Ser Gly Asn Tyr Leu Ala Val Thr 
            20                  25                  30          


Gly Ala Asp Tyr Ile Val Lys Ile Phe Asp Arg His Gly Gln Lys Arg 
        35                  40                  45              


Ser Glu Ile Asn Leu Pro Gly Asn Cys Val Ala Met Asp Trp Asp Lys 
    50                  55                  60                  


Asp Gly Asp Val Leu Ala Val Ile Ala Glu Lys Ser Ser Cys Ile Tyr 
65                  70                  75                  80  


Leu Trp Asp Ala Asn Thr Asn Lys Thr Ser Gln Leu Asp Asn Gly Met 
                85                  90                  95      


Arg Asp Gln Met Ser Phe Leu Leu Trp Ser Lys Val Gly Ser Phe Leu 
            100                 105                 110         


Ala Val Gly Thr Val Lys Gly Asn Leu Leu Ile Tyr Asn His Gln Thr 
        115                 120                 125             


Ser Arg Lys Ile Pro Val Leu Gly Lys His Thr Lys Arg Ile Thr Cys 
    130                 135                 140                 


Gly Cys Trp Asn Ala Glu Asn Leu Leu Ala Leu Gly Gly Glu Asp Lys 
145                 150                 155                 160 


Met Ile Thr Val Ser Asn Gln Glu Gly Asp Thr Ile Arg Gln Thr Gln 
                165                 170                 175     


Val Arg Ser Glu Pro Ser Asn Met Gln Phe Phe Leu Met Lys Met Asp 
            180                 185                 190         


Asp Arg Thr Ser Ala Ala Glu Ser Met Ile Ser Val Val Leu Gly Lys 
        195                 200                 205             


Lys Thr Leu Phe Phe Leu Asn Leu Asn Glu Pro Asp Asn Pro Ala Asp 
    210                 215                 220                 


Leu Glu Phe Gln Gln Asp Phe Gly Asn Ile Val Cys Tyr Asn Trp Tyr 
225                 230                 235                 240 


Gly Asp Gly Arg Ile Met Ile Gly Phe Ser Cys Gly His Phe Val Val 
                245                 250                 255     


Ile Ser Thr His Thr Gly Glu Leu Gly Gln Glu Ile Phe Gln Ala Arg 
            260                 265                 270         


Asn His Lys Asp Asn Leu Thr Ser Ile Ala Val Ser Gln Thr Leu Asn 
        275                 280                 285             


Lys Val Ala Thr Cys Gly Asp Asn Cys Ile Lys Ile Gln Asp Leu Val 
    290                 295                 300                 


Asp Leu Lys Asp Met Tyr Val Ile Leu Asn Leu Asp Glu Glu Asn Lys 
305                 310                 315                 320 


Gly Leu Gly Thr Leu Ser Trp Thr Asp Asp Gly Gln Leu Leu Ala Leu 
                325                 330                 335     


Ser Thr Gln Arg Gly Ser Leu His Val Phe Leu Thr Lys Leu Pro Ile 
            340                 345                 350         


Leu Gly Asp Ala Cys Ser Thr Arg Ile Ala Tyr Leu Thr Ser Leu Leu 
        355                 360                 365             


Glu Val Thr Val Ala Asn Pro Val Glu Gly Glu Leu Pro Ile Thr Val 
    370                 375                 380                 


Ser Val Asp Val Glu Pro Asn Phe Val Ala Val Gly Leu Tyr His Leu 
385                 390                 395                 400 


Ala Val Gly Met Asn Asn Arg Ala Trp Phe Tyr Val Leu Gly Glu Asn 
                405                 410                 415     


Ala Val Lys Lys Leu Lys Asp Met Glu Tyr Leu Gly Thr Val Ala Ser 
            420                 425                 430         


Ile Cys Leu His Ser Asp Tyr Ala Ala Ala Leu Phe Glu Gly Lys Val 
        435                 440                 445             


Gln Leu His Leu Ile Glu Ser Glu Ile Leu Asp Ala Gln Glu Glu Arg 
    450                 455                 460                 


Glu Thr Arg Leu Phe Pro Ala Val Asp Asp Lys Cys Arg Ile Leu Cys 
465                 470                 475                 480 


His Ala Leu Thr Ser Asp Phe Leu Ile Tyr Gly Thr Asp Thr Gly Val 
                485                 490                 495     


Val Gln Tyr Phe Tyr Ile Glu Asp Trp Gln Phe Val Asn Asp Tyr Arg 
            500                 505                 510         


His Pro Val Ser Val Lys Lys Ile Phe Pro Asp Pro Asn Gly Thr Arg 
        515                 520                 525             


Leu Val Phe Ile Asp Glu Lys Ser Asp Gly Phe Val Tyr Cys Pro Val 
    530                 535                 540                 


Asn Asp Ala Thr Tyr Glu Ile Pro Asp Phe Ser Pro Thr Ile Lys Gly 
545                 550                 555                 560 


Val Leu Trp Glu Asn Trp Pro Met Asp Lys Gly Val Phe Ile Ala Tyr 
                565                 570                 575     


Asp Asp Asp Lys Val Tyr Thr Tyr Val Phe His Lys Asp Thr Ile Gln 
            580                 585                 590         


Gly Ala Lys Val Ile Leu Ala Gly Ser Thr Lys Val Pro Phe Ala His 
        595                 600                 605             


Lys Pro Leu Leu Leu Tyr Asn Gly Glu Leu Thr Cys Gln Thr Gln Ser 
    610                 615                 620                 


Gly Lys Val Asn Asn Ile Tyr Leu Ser Thr His Gly Phe Leu Ser Asn 
625                 630                 635                 640 


Leu Lys Asp Thr Gly Pro Asp Glu Leu Arg Pro Met Leu Ala Gln Asn 
                645                 650                 655     


Leu Met Leu Lys Arg Phe Ser Asp Ala Trp Glu Met Cys Arg Ile Leu 
            660                 665                 670         


Asn Asp Glu Ala Ala Trp Asn Glu Leu Ala Arg Ala Cys Leu His His 
        675                 680                 685             


Met Glu Val Glu Phe Ala Ile Arg Val Tyr Arg Arg Ile Gly Asn Val 
    690                 695                 700                 


Gly Ile Val Met Ser Leu Glu Gln Ile Lys Gly Ile Glu Asp Tyr Asn 
705                 710                 715                 720 


Leu Leu Ala Gly His Leu Ala Met Phe Thr Asn Asp Tyr Asn Leu Ala 
                725                 730                 735     


Gln Asp Leu Tyr Leu Ala Ser Ser Cys Pro Ile Ala Ala Leu Glu Met 
            740                 745                 750         


Arg Arg Asp Leu Gln His Trp Asp Ser Ala Leu Gln Leu Ala Lys His 
        755                 760                 765             


Leu Ala Pro Asp Gln Ile Pro Phe Ile Ser Lys Glu Tyr Ala Ile Gln 
    770                 775                 780                 


Leu Glu Phe Ala Gly Asp Tyr Val Asn Ala Leu Ala His Tyr Glu Lys 
785                 790                 795                 800 


Gly Ile Thr Gly Asp Asn Lys Glu His Asp Glu Ala Cys Leu Ala Gly 
                805                 810                 815     


Val Ala Gln Met Ser Ile Arg Met Gly Asp Ile Arg Arg Gly Val Asn 
            820                 825                 830         


Gln Ala Leu Lys His Pro Ser Arg Val Leu Lys Arg Asp Cys Gly Ala 
        835                 840                 845             


Ile Leu Glu Asn Met Lys Gln Phe Ser Glu Ala Ala Gln Leu Tyr Glu 
    850                 855                 860                 


Lys Gly Leu Tyr Tyr Asp Lys Ala Ala Ser Val Tyr Ile Arg Ser Lys 
865                 870                 875                 880 


Asn Trp Ala Lys Val Gly Asp Leu Leu Pro His Val Ser Ser Pro Lys 
                885                 890                 895     


Ile His Leu Gln Tyr Ala Lys Ala Lys Glu Ala Asp Gly Arg Tyr Lys 
            900                 905                 910         


Glu Ala Val Val Ala Tyr Glu Asn Ala Lys Gln Trp Gln Ser Val Ile 
        915                 920                 925             


Arg Ile Tyr Leu Asp His Leu Asn Asn Pro Glu Lys Ala Val Asn Ile 
    930                 935                 940                 


Val Arg Glu Thr Gln Ser Leu Asp Gly Ala Lys Met Val Ala Arg Phe 
945                 950                 955                 960 


Phe Leu Gln Leu Gly Asp Tyr Gly Ser Ala Ile Gln Phe Leu Val Met 
                965                 970                 975     


Ser Lys Cys Asn Asn Glu Ala Phe Thr Leu Ala Gln Gln His Asn Lys 
            980                 985                 990         


Met Glu Ile Tyr Ala Asp Ile Ile  Gly Ser Glu Asp Thr  Thr Asn Glu 
        995                 1000                 1005             


Asp Tyr  Gln Ser Ile Ala Leu  Tyr Phe Glu Gly Glu  Lys Arg Tyr 
    1010                 1015                 1020             


Leu Gln  Ala Gly Lys Phe Phe  Leu Leu Cys Gly Gln  Tyr Ser Arg 
    1025                 1030                 1035             


Ala Leu  Lys His Phe Leu Lys  Cys Pro Ser Ser Glu  Asp Asn Val 
    1040                 1045                 1050             


Ala Ile  Glu Met Ala Ile Glu  Thr Val Gly Gln Ala  Lys Asp Glu 
    1055                 1060                 1065             


Leu Leu  Thr Asn Gln Leu Ile  Asp His Leu Leu Gly  Glu Asn Asp 
    1070                 1075                 1080             


Gly Met  Pro Lys Asp Ala Lys  Tyr Leu Phe Arg Leu  Tyr Met Ala 
    1085                 1090                 1095             


Leu Lys  Gln Tyr Arg Glu Ala  Ala Gln Thr Ala Ile  Ile Ile Ala 
    1100                 1105                 1110             


Arg Glu  Glu Gln Ser Ala Gly  Asn Tyr Arg Asn Ala  His Asp Val 
    1115                 1120                 1125             


Leu Phe  Ser Met Tyr Ala Glu  Leu Lys Ser Gln Lys  Ile Lys Ile 
    1130                 1135                 1140             


Pro Ser  Glu Met Ala Thr Asn  Leu Met Ile Leu His  Ser Tyr Ile 
    1145                 1150                 1155             


Leu Val  Lys Ile His Val Lys  Asn Gly Asp His Met  Lys Gly Ala 
    1160                 1165                 1170             


Arg Met  Leu Ile Arg Val Ala  Asn Asn Ile Ser Lys  Phe Pro Ser 
    1175                 1180                 1185             


His Ile  Val Pro Ile Leu Thr  Ser Thr Val Ile Glu  Cys His Arg 
    1190                 1195                 1200             


Ala Gly  Leu Lys Asn Ser Ala  Phe Ser Phe Ala Ala  Met Leu Met 
    1205                 1210                 1215             


Arg Pro  Glu Tyr Arg Ser Lys  Ile Asp Ala Lys Tyr  Lys Lys Lys 
    1220                 1225                 1230             


Ile Glu  Gly Met Val Arg Arg  Pro Asp Ile Ser Glu  Ile Glu Glu 
    1235                 1240                 1245             


Ala Thr  Thr Pro Cys Pro Phe  Cys Lys Phe Leu Leu  Pro Glu Cys 
    1250                 1255                 1260             


Glu Leu  Leu Cys Pro Gly Cys  Lys Asn Ser Ile Pro  Tyr Cys Ile 
    1265                 1270                 1275             


Ala Thr  Gly Arg His Met Leu  Lys Asp Asp Trp Thr  Val Cys Pro 
    1280                 1285                 1290             


His Cys  Asp Phe Pro Ala Leu  Tyr Ser Glu Leu Lys  Ile Met Leu 
    1295                 1300                 1305             


Asn Thr  Glu Ser Thr Cys Pro  Met Cys Ser Glu Arg  Leu Asn Ala 
    1310                 1315                 1320             


Ala Gln  Leu Lys Lys Ile Ser  Asp Cys Thr Gln Tyr  Leu Arg Thr 
    1325                 1330                 1335             


Glu Glu  Glu Leu 
    1340         


<210>  5125
<211>  1244
<212>  PRT
<213>  Homo sapiens

<400>  5125

Met Asn Asn Gln Lys Val Val Ala Val Leu Leu Gln Glu Cys Lys Gln 
1               5                   10                  15      


Val Leu Asp Gln Leu Leu Leu Glu Ala Pro Asp Val Ser Glu Glu Asp 
            20                  25                  30          


Lys Ser Glu Asp Gln Arg Cys Arg Ala Leu Leu Pro Ser Glu Leu Arg 
        35                  40                  45              


Thr Leu Ile Gln Glu Ala Lys Glu Met Lys Trp Pro Phe Val Pro Glu 
    50                  55                  60                  


Lys Trp Gln Tyr Lys Gln Ala Val Gly Pro Glu Asp Lys Thr Asn Leu 
65                  70                  75                  80  


Lys Asp Val Ile Gly Ala Gly Leu Gln Gln Leu Leu Ala Ser Leu Arg 
                85                  90                  95      


Ala Ser Ile Leu Ala Arg Asp Cys Ala Ala Ala Ala Ala Ile Val Phe 
            100                 105                 110         


Leu Val Asp Arg Phe Leu Tyr Gly Leu Asp Val Ser Gly Lys Leu Leu 
        115                 120                 125             


Gln Val Ala Lys Gly Leu His Lys Leu Gln Pro Ala Thr Pro Ile Ala 
    130                 135                 140                 


Pro Gln Val Val Ile Arg Gln Ala Arg Ile Ser Val Asn Ser Gly Lys 
145                 150                 155                 160 


Leu Leu Lys Ala Glu Tyr Ile Leu Ser Ser Leu Ile Ser Asn Asn Gly 
                165                 170                 175     


Ala Thr Gly Thr Trp Leu Tyr Arg Asn Glu Ser Asp Lys Val Leu Val 
            180                 185                 190         


Gln Ser Val Cys Ile Gln Ile Arg Gly Gln Ile Leu Gln Lys Leu Gly 
        195                 200                 205             


Met Trp Tyr Glu Ala Ala Glu Leu Ile Trp Ala Ser Ile Val Gly Tyr 
    210                 215                 220                 


Leu Ala Leu Pro Gln Pro Asp Lys Lys Gly Leu Ser Thr Ser Leu Gly 
225                 230                 235                 240 


Ile Leu Ala Asp Ile Phe Val Ser Met Ser Lys Asn Asp Tyr Glu Lys 
                245                 250                 255     


Phe Lys Asn Asn Pro Gln Ile Asn Leu Ser Leu Leu Lys Glu Phe Asp 
            260                 265                 270         


His His Leu Leu Ser Ala Ala Glu Ala Cys Lys Leu Ala Ala Ala Phe 
        275                 280                 285             


Ser Ala Tyr Thr Pro Leu Phe Val Leu Thr Ala Val Asn Ile Arg Gly 
    290                 295                 300                 


Thr Cys Leu Leu Ser Tyr Ser Ser Ser Asn Asp Cys Pro Pro Glu Leu 
305                 310                 315                 320 


Lys Asn Leu His Leu Cys Glu Ala Lys Glu Ala Phe Glu Ile Gly Leu 
                325                 330                 335     


Leu Thr Lys Arg Asp Asp Glu Pro Val Thr Gly Lys Gln Glu Leu His 
            340                 345                 350         


Ser Phe Val Lys Ala Ala Phe Gly Leu Thr Thr Val His Arg Arg Leu 
        355                 360                 365             


His Gly Glu Thr Gly Thr Val His Ala Ala Ser Gln Leu Cys Lys Glu 
    370                 375                 380                 


Ala Met Gly Lys Leu Tyr Asn Phe Ser Thr Ser Ser Arg Ser Gln Asp 
385                 390                 395                 400 


Arg Glu Ala Leu Ser Gln Glu Val Met Ser Val Ile Ala Gln Val Lys 
                405                 410                 415     


Glu His Leu Gln Val Gln Ser Phe Ser Asn Val Asp Asp Arg Ser Tyr 
            420                 425                 430         


Val Pro Glu Ser Phe Glu Cys Arg Leu Asp Lys Leu Ile Leu His Gly 
        435                 440                 445             


Gln Gly Asp Phe Gln Lys Ile Leu Asp Thr Tyr Ser Gln His His Thr 
    450                 455                 460                 


Ser Val Cys Glu Val Phe Glu Ser Asp Cys Gly Asn Asn Lys Asn Glu 
465                 470                 475                 480 


Gln Lys Asp Ala Lys Thr Gly Val Cys Ile Thr Ala Leu Lys Thr Glu 
                485                 490                 495     


Ile Lys Asn Ile Asp Thr Val Ser Thr Thr Gln Glu Lys Pro His Cys 
            500                 505                 510         


Gln Arg Asp Thr Gly Ile Ser Ser Ser Leu Met Gly Lys Asn Val Gln 
        515                 520                 525             


Arg Glu Leu Arg Arg Gly Gly Arg Arg Asn Trp Thr His Ser Asp Ala 
    530                 535                 540                 


Phe Arg Val Ser Leu Asp Gln Asp Val Glu Thr Glu Thr Glu Pro Ser 
545                 550                 555                 560 


Asp Tyr Ser Asn Gly Glu Gly Ala Val Phe Asn Lys Ser Leu Ser Gly 
                565                 570                 575     


Ser Gln Thr Ser Ser Ala Trp Ser Asn Leu Ser Gly Phe Ser Ser Ser 
            580                 585                 590         


Ala Ser Trp Glu Glu Val Asn Tyr His Val Asp Asp Arg Ser Ala Arg 
        595                 600                 605             


Lys Glu Pro Gly Lys Glu His Leu Val Asp Thr Gln Cys Ser Thr Ala 
    610                 615                 620                 


Leu Ser Glu Glu Leu Glu Asn Asp Arg Glu Gly Arg Ala Met His Ser 
625                 630                 635                 640 


Leu His Ser Gln Leu His Asp Leu Ser Leu Gln Glu Pro Asn Asn Asp 
                645                 650                 655     


Asn Leu Glu Pro Ser Gln Asn Gln Pro Gln Gln Gln Met Pro Leu Thr 
            660                 665                 670         


Pro Phe Ser Pro His Asn Thr Pro Gly Ile Phe Leu Ala Pro Gly Ala 
        675                 680                 685             


Gly Leu Leu Glu Gly Ala Pro Glu Gly Ile Gln Glu Val Arg Asn Met 
    690                 695                 700                 


Gly Pro Arg Asn Thr Ser Ala His Ser Arg Pro Ser Tyr Arg Ser Ala 
705                 710                 715                 720 


Ser Trp Ser Ser Asp Ser Gly Arg Pro Lys Asn Met Gly Thr His Pro 
                725                 730                 735     


Ser Val Gln Lys Glu Glu Ala Phe Glu Ile Ile Val Glu Phe Pro Glu 
            740                 745                 750         


Thr Asn Cys Asp Val Lys Asp Arg Gln Gly Lys Glu Gln Gly Glu Glu 
        755                 760                 765             


Ile Ser Glu Arg Gly Ala Gly Pro Thr Phe Lys Ala Ser Pro Ser Trp 
    770                 775                 780                 


Val Asp Pro Glu Gly Glu Thr Ala Glu Ser Thr Glu Asp Ala Pro Leu 
785                 790                 795                 800 


Asp Phe His Arg Val Leu His Asn Ser Leu Gly Asn Ile Ser Met Leu 
                805                 810                 815     


Pro Cys Ser Ser Phe Thr Pro Asn Trp Pro Val Gln Asn Pro Asp Ser 
            820                 825                 830         


Arg Lys Ser Gly Gly Pro Val Ala Glu Gln Gly Ile Asp Pro Asp Ala 
        835                 840                 845             


Ser Thr Val Asp Glu Glu Gly Gln Leu Leu Asp Ser Met Asp Val Pro 
    850                 855                 860                 


Cys Thr Asn Gly His Gly Ser His Arg Leu Cys Ile Leu Arg Gln Pro 
865                 870                 875                 880 


Pro Gly Gln Arg Ala Glu Thr Pro Asn Ser Ser Val Ser Gly Asn Ile 
                885                 890                 895     


Leu Phe Pro Val Leu Ser Glu Asp Cys Thr Thr Thr Glu Glu Gly Asn 
            900                 905                 910         


Gln Pro Gly Asn Met Leu Asn Cys Ser Gln Asn Ser Ser Ser Ser Ser 
        915                 920                 925             


Val Trp Trp Leu Lys Ser Pro Ala Phe Ser Ser Gly Ser Ser Glu Gly 
    930                 935                 940                 


Asp Ser Pro Trp Ser Tyr Leu Asn Ser Ser Gly Ser Ser Trp Val Ser 
945                 950                 955                 960 


Leu Pro Gly Lys Met Arg Lys Glu Ile Leu Glu Ala Arg Thr Leu Gln 
                965                 970                 975     


Pro Asp Asp Phe Glu Lys Leu Leu Ala Gly Val Arg His Asp Trp Leu 
            980                 985                 990         


Phe Gln Arg Leu Glu Asn Thr Gly  Val Phe Lys Pro Ser  Gln Leu His 
        995                 1000                 1005             


Arg Ala  His Ser Ala Leu Leu  Leu Lys Tyr Ser Lys  Lys Ser Glu 
    1010                 1015                 1020             


Leu Trp  Thr Ala Gln Glu Thr  Ile Val Tyr Leu Gly  Asp Tyr Leu 
    1025                 1030                 1035             


Thr Val  Lys Lys Lys Gly Arg  Gln Arg Asn Ala Phe  Trp Val His 
    1040                 1045                 1050             


His Leu  His Gln Glu Glu Ile  Leu Gly Arg Tyr Val  Gly Lys Asp 
    1055                 1060                 1065             


Tyr Lys  Glu Gln Lys Gly Leu  Trp His His Phe Thr  Asp Val Glu 
    1070                 1075                 1080             


Arg Gln  Met Thr Ala Gln His  Tyr Val Thr Glu Phe  Asn Lys Arg 
    1085                 1090                 1095             


Leu Tyr  Glu Gln Asn Ile Pro  Thr Gln Ile Phe Tyr  Ile Pro Ser 
    1100                 1105                 1110             


Thr Ile  Leu Leu Ile Leu Glu  Asp Lys Thr Ile Lys  Gly Cys Ile 
    1115                 1120                 1125             


Ser Val  Glu Pro Tyr Ile Leu  Gly Glu Phe Val Lys  Leu Ser Asn 
    1130                 1135                 1140             


Asn Thr  Lys Val Val Lys Thr  Glu Tyr Lys Ala Thr  Glu Tyr Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Gly His Phe Ser  Tyr Glu Phe Ser Asn  His Arg Asp 
    1160                 1165                 1170             


Val Val  Val Asp Leu Gln Gly  Trp Val Thr Gly Asn  Gly Lys Gly 
    1175                 1180                 1185             


Leu Ile  Tyr Leu Thr Asp Pro  Gln Ile His Ser Val  Asp Gln Lys 
    1190                 1195                 1200             


Val Phe  Thr Thr Asn Phe Gly  Lys Arg Gly Ile Phe  Tyr Phe Phe 
    1205                 1210                 1215             


Asn Asn  Gln His Val Glu Cys  Asn Glu Ile Cys His  Arg Leu Ser 
    1220                 1225                 1230             


Leu Thr  Arg Pro Ser Met Glu  Lys Pro Cys Thr 
    1235                 1240                 


<210>  5126
<211>  1461
<212>  PRT
<213>  Homo sapiens

<400>  5126

Met Ala Leu Ser Val Asp Ser Ser Trp His Arg Trp Gln Trp Arg Val 
1               5                   10                  15      


Arg Asp Gly Phe Pro His Cys Pro Ser Glu Thr Thr Pro Leu Leu Ser 
            20                  25                  30          


Pro Glu Lys Gly Arg Gln Ser Tyr Asn Leu Thr Gln Gln Arg Val Val 
        35                  40                  45              


Phe Pro Asn Asn Ser Ile Phe His Gln Asp Trp Glu Glu Val Ser Arg 
    50                  55                  60                  


Arg Tyr Pro Gly Asn Arg Thr Cys Thr Thr Lys Tyr Thr Leu Phe Thr 
65                  70                  75                  80  


Phe Leu Pro Arg Asn Leu Phe Glu Gln Phe His Arg Trp Ala Asn Leu 
                85                  90                  95      


Tyr Phe Leu Phe Leu Val Ile Leu Asn Trp Met Pro Ser Met Glu Val 
            100                 105                 110         


Phe His Arg Glu Ile Thr Met Leu Pro Leu Ala Ile Val Leu Phe Val 
        115                 120                 125             


Ile Met Ile Lys Asp Gly Met Glu Asp Phe Lys Arg His Arg Phe Asp 
    130                 135                 140                 


Lys Ala Ile Asn Cys Ser Asn Ile Arg Ile Tyr Glu Arg Lys Glu Gln 
145                 150                 155                 160 


Thr Tyr Val Gln Lys Cys Trp Lys Asp Val Arg Val Gly Asp Phe Ile 
                165                 170                 175     


Gln Met Lys Cys Asn Glu Ile Val Pro Ala Asp Ile Leu Leu Leu Phe 
            180                 185                 190         


Ser Ser Asp Pro Asn Gly Ile Cys His Leu Glu Thr Ala Ser Leu Asp 
        195                 200                 205             


Gly Glu Thr Asn Leu Lys Gln Arg Cys Val Val Lys Gly Phe Ser Gln 
    210                 215                 220                 


Gln Glu Val Gln Phe Glu Pro Glu Leu Phe His Asn Thr Ile Val Cys 
225                 230                 235                 240 


Glu Lys Pro Asn Asn His Leu Asn Lys Phe Lys Gly Tyr Met Glu His 
                245                 250                 255     


Pro Asp Gln Thr Arg Thr Gly Phe Gly Cys Glu Ser Leu Leu Leu Arg 
            260                 265                 270         


Gly Cys Thr Ile Arg Asn Thr Glu Met Ala Val Gly Ile Val Ile Tyr 
        275                 280                 285             


Ala Gly His Glu Thr Lys Ala Met Leu Asn Asn Ser Gly Pro Arg Tyr 
    290                 295                 300                 


Lys Arg Ser Lys Ile Glu Arg Arg Met Asn Ile Asp Ile Phe Phe Cys 
305                 310                 315                 320 


Ile Gly Ile Leu Ile Leu Met Cys Leu Ile Gly Ala Val Gly His Ser 
                325                 330                 335     


Ile Trp Asn Gly Thr Phe Glu Glu His Pro Pro Phe Asp Val Pro Asp 
            340                 345                 350         


Ala Asn Gly Ser Phe Leu Pro Ser Ala Leu Gly Gly Phe Tyr Met Phe 
        355                 360                 365             


Leu Thr Met Ile Ile Leu Leu Gln Val Leu Ile Pro Ile Ser Leu Tyr 
    370                 375                 380                 


Val Ser Ile Glu Leu Val Lys Leu Gly Gln Val Phe Phe Leu Ser Asn 
385                 390                 395                 400 


Asp Leu Asp Leu Tyr Asp Glu Glu Thr Asp Leu Ser Ile Gln Cys Arg 
                405                 410                 415     


Ala Leu Asn Ile Ala Glu Asp Leu Gly Gln Ile Gln Tyr Ile Phe Ser 
            420                 425                 430         


Asp Lys Thr Gly Thr Leu Thr Glu Asn Lys Met Val Phe Arg Arg Cys 
        435                 440                 445             


Thr Ile Met Gly Ser Glu Tyr Ser His Gln Glu Asn Ala Lys Arg Leu 
    450                 455                 460                 


Glu Thr Pro Lys Glu Leu Asp Ser Asp Gly Glu Glu Trp Thr Gln Tyr 
465                 470                 475                 480 


Gln Cys Leu Ser Phe Ser Ala Arg Trp Ala Gln Asp Pro Ala Thr Met 
                485                 490                 495     


Arg Ser Gln Lys Gly Ala Gln Pro Leu Arg Arg Ser Gln Ser Ala Arg 
            500                 505                 510         


Val Pro Ile Gln Gly His Tyr Arg Gln Arg Ser Met Gly His Arg Glu 
        515                 520                 525             


Ser Ser Gln Pro Pro Val Ala Phe Ser Ser Ser Ile Glu Lys Asp Val 
    530                 535                 540                 


Thr Pro Asp Lys Asn Leu Leu Thr Lys Val Arg Asp Ala Ala Leu Trp 
545                 550                 555                 560 


Leu Glu Thr Leu Ser Asp Ser Arg Pro Ala Lys Ala Ser Leu Ser Thr 
                565                 570                 575     


Thr Ser Ser Ile Ala Asp Phe Phe Leu Ala Leu Thr Ile Cys Asn Ser 
            580                 585                 590         


Val Met Val Ser Thr Thr Thr Glu Pro Arg Gln Arg Val Thr Ile Lys 
        595                 600                 605             


Pro Ser Ser Lys Ala Leu Gly Thr Ser Leu Glu Lys Ile Gln Gln Leu 
    610                 615                 620                 


Phe Gln Lys Leu Lys Leu Leu Ser Leu Ser Gln Ser Phe Ser Ser Thr 
625                 630                 635                 640 


Ala Pro Ser Asp Thr Asp Leu Gly Glu Ser Leu Gly Ala Asn Val Ala 
                645                 650                 655     


Thr Thr Asp Ser Asp Glu Arg Asp Asp Ala Ser Val Cys Ser Gly Gly 
            660                 665                 670         


Asp Ser Thr Asp Asp Gly Gly Tyr Arg Ser Ser Met Trp Asp Gln Gly 
        675                 680                 685             


Asp Ile Leu Glu Ser Gly Ser Gly Thr Ser Leu Glu Glu Ala Leu Glu 
    690                 695                 700                 


Ala Pro Ala Thr Asp Leu Ala Arg Pro Glu Phe Cys Tyr Glu Ala Glu 
705                 710                 715                 720 


Ser Pro Asp Glu Ala Ala Leu Val His Ala Ala His Ala Tyr Ser Phe 
                725                 730                 735     


Thr Leu Val Ser Arg Thr Pro Glu Gln Val Thr Val Arg Leu Pro Gln 
            740                 745                 750         


Gly Thr Cys Leu Thr Phe Ser Leu Leu Cys Thr Leu Gly Phe Asp Ser 
        755                 760                 765             


Val Arg Lys Arg Met Ser Val Val Val Arg His Pro Leu Thr Gly Glu 
    770                 775                 780                 


Ile Val Val Tyr Thr Lys Gly Ala Asp Ser Val Ile Met Asp Leu Leu 
785                 790                 795                 800 


Glu Asp Pro Ala Cys Val Pro Asp Ile Asn Met Glu Lys Lys Leu Arg 
                805                 810                 815     


Lys Ile Arg Ala Arg Thr Gln Lys His Leu Asp Leu Tyr Ala Arg Asp 
            820                 825                 830         


Gly Leu Arg Thr Leu Cys Ile Ala Lys Lys Val Val Ser Glu Glu Asp 
        835                 840                 845             


Phe Arg Arg Trp Ala Ser Phe Arg Arg Glu Ala Glu Ala Ser Leu Asp 
    850                 855                 860                 


Asn Arg Asp Glu Leu Leu Met Glu Thr Ala Gln His Leu Glu Asn Gln 
865                 870                 875                 880 


Leu Thr Leu Leu Gly Ala Thr Gly Ile Glu Asp Arg Leu Gln Glu Gly 
                885                 890                 895     


Val Pro Asp Thr Ile Ala Thr Leu Arg Glu Ala Gly Ile Gln Leu Trp 
            900                 905                 910         


Val Leu Thr Gly Asp Lys Gln Glu Thr Ala Val Asn Ile Ala His Ser 
        915                 920                 925             


Cys Arg Leu Leu Asn Gln Thr Asp Thr Val Tyr Thr Ile Asn Thr Glu 
    930                 935                 940                 


Asn Gln Glu Thr Cys Glu Ser Ile Leu Asn Cys Ala Leu Glu Glu Leu 
945                 950                 955                 960 


Lys Gln Phe Arg Glu Leu Gln Lys Pro Asp Arg Lys Leu Phe Gly Phe 
                965                 970                 975     


Arg Leu Pro Ser Lys Thr Pro Ser Ile Thr Ser Glu Ala Val Val Pro 
            980                 985                 990         


Glu Ala Gly Leu Val Ile Asp Gly  Lys Thr Leu Asn Ala  Ile Phe Gln 
        995                 1000                 1005             


Gly Lys  Leu Glu Lys Lys Phe  Leu Glu Leu Thr Gln  Tyr Cys Arg 
    1010                 1015                 1020             


Ser Val  Leu Cys Cys Arg Ser  Thr Pro Leu Gln Lys  Ser Met Ile 
    1025                 1030                 1035             


Val Lys  Leu Val Arg Asp Lys  Leu Arg Val Met Thr  Leu Ser Ile 
    1040                 1045                 1050             


Gly Asp  Gly Ala Asn Asp Val  Ser Met Ile Gln Ala  Ala Asp Ile 
    1055                 1060                 1065             


Gly Ile  Gly Ile Ser Gly Gln  Glu Gly Met Gln Ala  Val Met Ser 
    1070                 1075                 1080             


Ser Asp  Phe Ala Ile Thr Arg  Phe Lys His Leu Lys  Lys Leu Leu 
    1085                 1090                 1095             


Leu Val  His Gly His Trp Cys  Tyr Ser Arg Leu Ala  Arg Met Val 
    1100                 1105                 1110             


Val Tyr  Tyr Leu Tyr Lys Asn  Val Cys Tyr Val Asn  Leu Leu Phe 
    1115                 1120                 1125             


Trp Tyr  Gln Phe Phe Cys Gly  Phe Ser Ser Ser Thr  Met Ile Asp 
    1130                 1135                 1140             


Tyr Trp  Gln Met Ile Phe Phe  Asn Leu Phe Phe Thr  Ser Leu Pro 
    1145                 1150                 1155             


Pro Leu  Val Phe Gly Val Leu  Asp Lys Asp Ile Ser  Ala Glu Thr 
    1160                 1165                 1170             


Leu Leu  Ala Leu Pro Glu Leu  Tyr Lys Ser Gly Gln  Asn Ser Glu 
    1175                 1180                 1185             


Cys Tyr  Asn Leu Ser Thr Phe  Trp Ile Ser Met Val  Asp Ala Phe 
    1190                 1195                 1200             


Tyr Gln  Ser Leu Ile Cys Phe  Phe Ile Pro Tyr Leu  Ala Tyr Lys 
    1205                 1210                 1215             


Gly Ser  Asp Ile Asp Val Phe  Thr Phe Gly Thr Pro  Ile Asn Thr 
    1220                 1225                 1230             


Ile Ser  Leu Thr Thr Ile Leu  Leu His Gln Ala Met  Glu Met Lys 
    1235                 1240                 1245             


Thr Trp  Thr Ile Phe His Gly  Val Val Leu Leu Gly  Ser Phe Leu 
    1250                 1255                 1260             


Met Tyr  Phe Leu Val Ser Leu  Leu Tyr Asn Ala Thr  Cys Val Ile 
    1265                 1270                 1275             


Cys Asn  Ser Pro Thr Asn Pro  Tyr Trp Val Met Glu  Gly Gln Leu 
    1280                 1285                 1290             


Ser Asn  Pro Thr Phe Tyr Leu  Val Cys Phe Leu Thr  Pro Val Val 
    1295                 1300                 1305             


Ala Leu  Leu Pro Arg Tyr Phe  Phe Leu Ser Leu Gln  Gly Thr Cys 
    1310                 1315                 1320             


Gly Lys  Ser Leu Ile Ser Lys  Ala Gln Lys Ile Asp  Lys Leu Pro 
    1325                 1330                 1335             


Pro Asp  Lys Arg Asn Leu Glu  Ile Gln Ser Trp Arg  Ser Arg Gln 
    1340                 1345                 1350             


Arg Pro  Ala Pro Val Pro Glu  Val Ala Arg Pro Thr  His His Pro 
    1355                 1360                 1365             


Val Ser  Ser Ile Thr Gly Gln  Asp Phe Ser Ala Ser  Thr Pro Lys 
    1370                 1375                 1380             


Ser Ser  Asn Pro Pro Lys Arg  Lys His Val Glu Glu  Ser Val Leu 
    1385                 1390                 1395             


His Glu  Gln Arg Cys Gly Thr  Glu Cys Met Arg Asp  Asp Ser Cys 
    1400                 1405                 1410             


Ser Gly  Asp Ser Ser Ala Gln  Leu Ser Ser Gly Glu  His Leu Leu 
    1415                 1420                 1425             


Gly Pro  Asn Arg Ile Met Ala  Tyr Ser Arg Gly Gln  Thr Asp Met 
    1430                 1435                 1440             


Cys Arg  Cys Ser Lys Arg Ser  Ser His Arg Arg Ser  Gln Ser Ser 
    1445                 1450                 1455             


Leu Thr  Ile 
    1460     


<210>  5127
<211>  702
<212>  PRT
<213>  Homo sapiens

<400>  5127

Met Ser Arg Arg Ser Leu Arg Leu Ala Thr Thr Ala Cys Thr Leu Gly 
1               5                   10                  15      


Asp Gly Glu Ala Val Gly Ala Asp Ser Gly Thr Ser Ser Ala Val Ser 
            20                  25                  30          


Leu Lys Asn Arg Ala Ala Arg Thr Thr Lys Gln Arg Arg Ser Thr Asn 
        35                  40                  45              


Lys Ser Ala Phe Ser Ile Asn His Val Ser Arg Gln Val Thr Ser Ser 
    50                  55                  60                  


Gly Val Ser His Gly Gly Thr Val Ser Leu Gln Asp Ala Val Thr Arg 
65                  70                  75                  80  


Arg Pro Pro Val Leu Asp Glu Ser Trp Ile Arg Glu Gln Thr Thr Val 
                85                  90                  95      


Asp His Phe Trp Gly Leu Asp Asp Asp Gly Asp Leu Lys Gly Gly Asn 
            100                 105                 110         


Lys Ala Ala Ile Gln Gly Asn Gly Asp Val Gly Ala Ala Ala Ala Thr 
        115                 120                 125             


Ala His Asn Gly Phe Ser Cys Ser Asn Cys Ser Met Leu Ser Glu Arg 
    130                 135                 140                 


Lys Asp Val Leu Thr Ala His Pro Ala Ala Pro Gly Pro Val Ser Arg 
145                 150                 155                 160 


Val Tyr Ser Arg Asp Arg Asn Gln Lys Trp Lys Ala Ala Ser Gly Val 
                165                 170                 175     


Phe Trp Trp Leu Gly Ile Gly Trp Tyr Gln Phe Val Thr Leu Ile Ser 
            180                 185                 190         


Trp Leu Asn Val Phe Leu Leu Thr Arg Cys Leu Arg Asn Ile Cys Lys 
        195                 200                 205             


Phe Leu Val Leu Leu Ile Pro Leu Phe Leu Leu Leu Ala Gly Leu Ser 
    210                 215                 220                 


Leu Arg Gly Gln Gly Asn Phe Phe Ser Phe Leu Pro Val Leu Asn Trp 
225                 230                 235                 240 


Ala Ser Met His Arg Thr Gln Arg Val Asp Asp Pro Gln Asp Val Phe 
                245                 250                 255     


Lys Pro Thr Thr Ser Arg Leu Lys Gln Pro Leu Gln Gly Asp Ser Glu 
            260                 265                 270         


Ala Phe Pro Trp His Trp Met Ser Gly Val Glu Gln Gln Val Ala Ser 
        275                 280                 285             


Leu Ser Gly Gln Cys His His His Gly Glu Asn Leu Arg Glu Leu Thr 
    290                 295                 300                 


Thr Leu Leu Gln Lys Leu Gln Ala Arg Val Asp Gln Met Glu Gly Gly 
305                 310                 315                 320 


Ala Ala Gly Pro Ser Ala Ser Val Arg Asp Ala Val Gly Gln Pro Pro 
                325                 330                 335     


Arg Glu Thr Asp Phe Met Ala Phe His Gln Glu His Glu Val Arg Met 
            340                 345                 350         


Ser His Leu Glu Asp Ile Leu Gly Lys Leu Arg Glu Lys Ser Glu Ala 
        355                 360                 365             


Ile Gln Lys Glu Leu Glu Gln Thr Lys Gln Lys Thr Ile Ser Ala Val 
    370                 375                 380                 


Gly Glu Gln Leu Leu Pro Thr Val Glu His Leu Gln Leu Glu Leu Asp 
385                 390                 395                 400 


Gln Leu Lys Ser Glu Leu Ser Ser Trp Arg His Val Lys Thr Gly Cys 
                405                 410                 415     


Glu Thr Val Asp Ala Val Gln Glu Arg Val Asp Val Gln Val Arg Glu 
            420                 425                 430         


Met Val Lys Leu Leu Phe Ser Glu Asp Gln Gln Gly Gly Ser Leu Glu 
        435                 440                 445             


Gln Leu Leu Gln Arg Phe Ser Ser Gln Phe Val Ser Lys Gly Asp Leu 
    450                 455                 460                 


Gln Thr Met Leu Arg Asp Leu Gln Leu Gln Ile Leu Arg Asn Val Thr 
465                 470                 475                 480 


His His Val Ser Val Thr Lys Gln Leu Pro Thr Ser Glu Ala Val Val 
                485                 490                 495     


Ser Ala Val Ser Glu Ala Gly Ala Ser Gly Ile Thr Glu Ala Gln Ala 
            500                 505                 510         


Arg Ala Ile Val Asn Ser Ala Leu Lys Leu Tyr Ser Gln Asp Lys Thr 
        515                 520                 525             


Gly Met Val Asp Phe Ala Leu Glu Ser Gly Gly Gly Ser Ile Leu Ser 
    530                 535                 540                 


Thr Arg Cys Ser Glu Thr Tyr Glu Thr Lys Thr Ala Leu Met Ser Leu 
545                 550                 555                 560 


Phe Gly Ile Pro Leu Trp Tyr Phe Ser Gln Ser Pro Arg Val Val Ile 
                565                 570                 575     


Gln Pro Asp Ile Tyr Pro Gly Asn Cys Trp Ala Phe Lys Gly Ser Gln 
            580                 585                 590         


Gly Tyr Leu Val Val Arg Leu Ser Met Met Ile His Pro Ala Ala Phe 
        595                 600                 605             


Thr Leu Glu His Ile Pro Lys Thr Leu Ser Pro Thr Gly Asn Ile Ser 
    610                 615                 620                 


Ser Ala Pro Lys Asp Phe Ala Val Tyr Gly Leu Glu Asn Glu Tyr Gln 
625                 630                 635                 640 


Glu Glu Gly Gln Leu Leu Gly Gln Phe Thr Tyr Asp Gln Asp Gly Glu 
                645                 650                 655     


Ser Leu Gln Met Phe Gln Ala Leu Lys Arg Pro Asp Asp Thr Ala Phe 
            660                 665                 670         


Gln Ile Val Glu Leu Arg Ile Phe Ser Asn Trp Gly His Pro Glu Tyr 
        675                 680                 685             


Thr Cys Leu Tyr Arg Phe Arg Val His Gly Glu Pro Val Lys 
    690                 695                 700         


<210>  5128
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  5128

Met Ala Ala Pro Leu Arg Ile Gln Ser Asp Trp Ala Gln Ala Leu Arg 
1               5                   10                  15      


Lys Asp Glu Gly Glu Ala Trp Leu Ser Cys His Pro Pro Gly Lys Pro 
            20                  25                  30          


Ser Leu Tyr Gly Ser Leu Thr Cys Gln Gly Ile Gly Leu Asp Gly Ile 
        35                  40                  45              


Pro Glu Val Thr Ala Ser Glu Gly Phe Thr Val Asn Glu Ile Asn Lys 
    50                  55                  60                  


Lys Ser Ile His Ile Ser Cys Pro Lys Glu Asn Ala Ser Ser Lys Phe 
65                  70                  75                  80  


Leu Ala Pro Tyr Thr Thr Phe Ser Arg Ile His Thr Lys Ser Ile Thr 
                85                  90                  95      


Cys Leu Asp Ile Ser Ser Arg Gly Gly Leu Gly Val Ser Ser Ser Thr 
            100                 105                 110         


Asp Gly Thr Met Lys Ile Trp Gln Ala Ser Asn Gly Glu Leu Arg Arg 
        115                 120                 125             


Val Leu Glu Gly His Val Phe Asp Val Asn Cys Cys Arg Phe Phe Pro 
    130                 135                 140                 


Ser Gly Leu Val Val Leu Ser Gly Gly Met Asp Ala Gln Leu Lys Ile 
145                 150                 155                 160 


Trp Ser Ala Glu Asp Ala Ser Cys Val Val Thr Phe Lys Gly His Lys 
                165                 170                 175     


Gly Gly Ile Leu Asp Thr Ala Ile Val Asp Arg Gly Arg Asn Val Val 
            180                 185                 190         


Ser Ala Ser Arg Asp Gly Thr Ala Arg Leu Trp Asp Cys Gly Arg Ser 
        195                 200                 205             


Ala Cys Leu Gly Val Leu Ala Asp Cys Gly Ser Ser Ile Asn Gly Val 
    210                 215                 220                 


Ala Val Gly Ala Ala Asp Asn Ser Ile Asn Leu Gly Ser Pro Glu Gln 
225                 230                 235                 240 


Met Pro Ser Glu Arg Glu Val Gly Thr Glu Ala Lys Met Leu Leu Leu 
                245                 250                 255     


Ala Arg Glu Asp Lys Lys Leu Gln Cys Leu Gly Leu Gln Ser Arg Gln 
            260                 265                 270         


Leu Val Phe Leu Phe Ile Gly Ser Asp Ala Phe Asn Cys Cys Thr Phe 
        275                 280                 285             


Leu Ser Gly Phe Leu Leu Leu Ala Gly Thr Gln Asp Gly Asn Ile Tyr 
    290                 295                 300                 


Gln Leu Asp Val Arg Ser Pro Arg Ala Pro Val Gln Val Ile His Arg 
305                 310                 315                 320 


Ser Gly Ala Pro Val Leu Ser Leu Leu Ser Val Arg Asp Gly Phe Ile 
                325                 330                 335     


Ala Ser Gln Gly Asp Gly Ser Cys Phe Ile Val Gln Gln Asp Leu Asp 
            340                 345                 350         


Tyr Val Thr Glu Leu Thr Gly Ala Asp Cys Asp Pro Val Tyr Lys Val 
        355                 360                 365             


Ala Thr Trp Glu Lys Gln Ile Tyr Thr Cys Cys Arg Asp Gly Leu Val 
    370                 375                 380                 


Arg Arg Tyr Gln Leu Ser Asp Leu 
385                 390         


<210>  5129
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  5129

Met Gln Ile Cys Gly Ser Ser Val Ala Ser Val Ala Ala Gly Thr Ser 
1               5                   10                  15      


Phe Gln Val Leu Gly Pro Val Cys Trp Gln Gln Leu Asp Leu Lys Met 
            20                  25                  30          


Ala Val Arg Val Leu Trp Gly Gly Leu Ser Leu Leu Arg Val Leu Trp 
        35                  40                  45              


Cys Leu Leu Pro Gln Thr Gly Tyr Val His Pro Asp Glu Phe Phe Gln 
    50                  55                  60                  


Ser Pro Glu Val Met Ala Glu Asp Ile Leu Gly Val Gln Ala Ala Arg 
65                  70                  75                  80  


Pro Trp Glu Phe Tyr Pro Ser Ser Ser Cys Arg Ser Val Leu Phe Pro 
                85                  90                  95      


Leu Leu Ile Ser Gly Ser Thr Phe Trp Leu Leu Arg Leu Trp Glu Glu 
            100                 105                 110         


Leu Gly Pro Trp Pro Gly Leu Val Ser Gly Tyr Ala Leu Leu Val Gly 
        115                 120                 125             


Pro Arg Leu Leu Leu Thr Ala Leu Ser Phe Ala Leu Asp Gly Ala Val 
    130                 135                 140                 


Tyr His Leu Ala Pro Pro Met Gly Ala Asp Arg Trp Asn Ala Leu Ala 
145                 150                 155                 160 


Leu Leu Ser Gly Ser Tyr Val Thr Leu Val Phe Tyr Thr Arg Thr Phe 
                165                 170                 175     


Ser Asn Thr Ile Glu Gly Leu Leu Phe Thr Trp Leu Leu Val Leu Val 
            180                 185                 190         


Ser Ser His Val Thr Trp Gly Pro Thr Arg Lys Glu Pro Ala Pro Gly 
        195                 200                 205             


Pro Arg Trp Arg Ser Trp Leu Leu Gly Gly Ile Val Ala Ala Gly Phe 
    210                 215                 220                 


Phe Asn Arg Pro Thr Phe Leu Ala Phe Ala Val Val Pro Leu Tyr Leu 
225                 230                 235                 240 


Trp Gly Thr Arg Gly Ala Thr Asn Pro Gly Leu Lys Ser Leu Thr Arg 
                245                 250                 255     


Glu Ala Leu Val Leu Leu Pro Gly Ala Ala Leu Thr Ala Ala Val Phe 
            260                 265                 270         


Val Ala Thr Asp Ser Trp Tyr Phe Ser Ser Pro Ala Thr Ser Arg Asn 
        275                 280                 285             


Leu Val Leu Thr Pro Val Asn Phe Leu His Tyr Asn Leu Asn Pro Gln 
    290                 295                 300                 


Asn Leu Ala Arg His Gly Thr His Ala Arg Leu Thr His Leu Ala Val 
305                 310                 315                 320 


Asn Gly Phe Leu Leu Phe Gly Val Leu His Ala Gln Ala Leu Gln Ala 
                325                 330                 335     


Ala Trp Gln Arg Leu Gln Val Gly Leu Gln Ala Ser Ala Gln Met Gly 
            340                 345                 350         


Leu Leu Arg Ala Leu Gly Ala Arg Ser Leu Leu Ser Ser Pro Arg Ser 
        355                 360                 365             


Tyr Leu Leu Leu Leu Tyr Phe Met Pro Leu Ala Leu Leu Ser Ala Phe 
    370                 375                 380                 


Ser His Gln Glu Ala Arg Phe Leu Ile Pro Leu Leu Val Pro Leu Val 
385                 390                 395                 400 


Leu Leu Cys Ser Pro Gln Thr Gln Pro Val Pro Trp Lys Gly Thr Val 
                405                 410                 415     


Val Leu Phe Asn Ala Leu Gly Ala Leu Leu Phe Gly Cys Leu His Gln 
            420                 425                 430         


Gly Gly Leu Val Pro Gly Leu Glu Tyr Leu Glu Gln Val Val His Ala 
        435                 440                 445             


Pro Val Leu Pro Ser Thr Pro Thr His Tyr Thr Leu Leu Phe Thr His 
    450                 455                 460                 


Thr Tyr Met Pro Pro Arg His Leu Leu His Leu Pro Gly Leu Gly Ala 
465                 470                 475                 480 


Pro Val Glu Val Val Asp Met Gly Gly Thr Glu Asp Trp Ala Leu Cys 
                485                 490                 495     


Gln Thr Leu Lys Ser Phe Thr Arg Gln Pro Ala Cys Gln Val Ala Gly 
            500                 505                 510         


Gly Pro Trp Leu Cys Arg Leu Phe Val Val Thr Pro Gly Thr Thr Arg 
        515                 520                 525             


Arg Ala Val Glu Lys Cys Ser Phe Pro Phe Lys Asn Glu Thr Leu Leu 
    530                 535                 540                 


Phe Pro His Leu Thr Leu Glu Asp Pro Pro Ala Leu Ser Ser Leu Leu 
545                 550                 555                 560 


Ser Gly Ala Trp Arg Asp His Leu Ser Leu His Ile Val Glu Leu Gly 
                565                 570                 575     


Glu Glu Thr 
            


<210>  5130
<211>  1894
<212>  PRT
<213>  Homo sapiens

<400>  5130

Met Glu Gln Arg Arg Pro Trp Pro Arg Ala Leu Glu Val Asp Ser Arg 
1               5                   10                  15      


Ser Val Val Leu Leu Ser Val Val Trp Val Leu Leu Ala Pro Pro Ala 
            20                  25                  30          


Ala Gly Met Pro Gln Phe Ser Thr Phe His Ser Glu Asn Arg Asp Trp 
        35                  40                  45              


Thr Phe Asn His Leu Thr Val His Gln Gly Thr Gly Ala Val Tyr Val 
    50                  55                  60                  


Gly Ala Ile Asn Arg Val Tyr Lys Leu Thr Gly Asn Leu Thr Ile Gln 
65                  70                  75                  80  


Val Ala His Lys Thr Gly Pro Glu Glu Asp Asn Lys Ser Cys Tyr Pro 
                85                  90                  95      


Pro Leu Ile Val Gln Pro Cys Ser Glu Val Leu Thr Leu Thr Asn Asn 
            100                 105                 110         


Val Asn Lys Leu Leu Ile Ile Asp Tyr Ser Glu Asn Arg Leu Leu Ala 
        115                 120                 125             


Cys Gly Ser Leu Tyr Gln Gly Val Cys Lys Leu Leu Arg Leu Asp Asp 
    130                 135                 140                 


Leu Phe Ile Leu Val Glu Pro Ser His Lys Lys Glu His Tyr Leu Ser 
145                 150                 155                 160 


Ser Val Asn Lys Thr Gly Thr Met Tyr Gly Val Ile Val Arg Ser Glu 
                165                 170                 175     


Gly Glu Asp Gly Lys Leu Phe Ile Gly Thr Ala Val Asp Gly Lys Gln 
            180                 185                 190         


Asp Tyr Phe Pro Thr Leu Ser Ser Arg Lys Leu Pro Arg Asp Pro Glu 
        195                 200                 205             


Ser Ser Ala Met Leu Asp Tyr Glu Leu His Ser Asp Phe Val Ser Ser 
    210                 215                 220                 


Leu Ile Lys Ile Pro Ser Asp Thr Leu Ala Leu Val Ser His Phe Asp 
225                 230                 235                 240 


Ile Phe Tyr Ile Tyr Gly Phe Ala Ser Gly Gly Phe Val Tyr Phe Leu 
                245                 250                 255     


Thr Val Gln Pro Glu Thr Pro Glu Gly Val Ala Ile Asn Ser Ala Gly 
            260                 265                 270         


Asp Leu Phe Tyr Thr Ser Arg Ile Val Arg Leu Cys Lys Asp Asp Pro 
        275                 280                 285             


Lys Phe His Ser Tyr Val Ser Leu Pro Phe Gly Cys Thr Arg Ala Gly 
    290                 295                 300                 


Val Glu Tyr Arg Leu Leu Gln Ala Ala Tyr Leu Ala Lys Pro Gly Asp 
305                 310                 315                 320 


Ser Leu Ala Gln Ala Phe Asn Ile Thr Ser Gln Asp Asp Val Leu Phe 
                325                 330                 335     


Ala Ile Phe Ser Lys Gly Gln Lys Gln Tyr His His Pro Pro Asp Asp 
            340                 345                 350         


Ser Ala Leu Cys Ala Phe Pro Ile Arg Ala Ile Asn Leu Gln Ile Lys 
        355                 360                 365             


Glu Arg Leu Gln Ser Cys Tyr Gln Gly Glu Gly Asn Leu Glu Leu Asn 
    370                 375                 380                 


Trp Leu Leu Gly Lys Asp Val Gln Cys Thr Lys Ala Pro Val Pro Ile 
385                 390                 395                 400 


Asp Asp Asn Phe Cys Gly Leu Asp Ile Asn Gln Pro Leu Gly Gly Ser 
                405                 410                 415     


Thr Pro Val Glu Gly Leu Thr Leu Tyr Thr Thr Ser Arg Asp Arg Met 
            420                 425                 430         


Thr Ser Val Ala Ser Tyr Val Tyr Asn Gly Tyr Ser Val Val Phe Val 
        435                 440                 445             


Gly Thr Lys Ser Gly Lys Leu Lys Lys Ile Arg Ala Asp Gly Pro Pro 
    450                 455                 460                 


His Gly Gly Val Gln Tyr Glu Met Val Ser Val Leu Lys Asp Gly Ser 
465                 470                 475                 480 


Pro Ile Leu Arg Asp Met Ala Phe Ser Ile Asp Gln Arg Tyr Leu Tyr 
                485                 490                 495     


Val Met Ser Glu Arg Gln Val Thr Arg Val Pro Val Glu Ser Cys Glu 
            500                 505                 510         


Gln Tyr Thr Thr Cys Gly Glu Cys Leu Ser Ser Gly Asp Pro His Cys 
        515                 520                 525             


Gly Trp Cys Ala Leu His Asn Met Cys Ser Arg Arg Asp Lys Cys Gln 
    530                 535                 540                 


Gln Ala Trp Glu Pro Asn Arg Phe Ala Ala Ser Ile Ser Gln Cys Val 
545                 550                 555                 560 


Ser Leu Ala Val His Pro Ser Ser Ile Ser Val Ser Glu His Ser Arg 
                565                 570                 575     


Leu Leu Ser Leu Val Val Ser Asp Ala Pro Asp Leu Ser Ala Gly Ile 
            580                 585                 590         


Ala Cys Ala Phe Gly Asn Leu Thr Glu Val Glu Gly Gln Val Ser Gly 
        595                 600                 605             


Ser Gln Val Ile Cys Ile Ser Pro Gly Pro Lys Asp Val Pro Val Ile 
    610                 615                 620                 


Pro Leu Asp Gln Asp Trp Phe Gly Leu Glu Leu Gln Leu Arg Ser Lys 
625                 630                 635                 640 


Glu Thr Gly Lys Ile Phe Val Ser Thr Glu Phe Lys Phe Tyr Asn Cys 
                645                 650                 655     


Ser Ala His Gln Leu Cys Leu Ser Cys Val Asn Ser Ala Phe Arg Cys 
            660                 665                 670         


His Trp Cys Lys Tyr Arg Asn Leu Cys Thr His Asp Pro Thr Thr Cys 
        675                 680                 685             


Ser Phe Gln Glu Gly Arg Ile Asn Ile Ser Glu Asp Cys Pro Gln Leu 
    690                 695                 700                 


Val Pro Thr Glu Glu Ile Leu Ile Pro Val Gly Glu Val Lys Pro Ile 
705                 710                 715                 720 


Thr Leu Lys Ala Arg Asn Leu Pro Gln Pro Gln Ser Gly Gln Arg Gly 
                725                 730                 735     


Tyr Glu Cys Val Leu Asn Ile Gln Gly Ala Ile His Arg Val Pro Ala 
            740                 745                 750         


Leu Arg Phe Asn Ser Ser Ser Val Gln Cys Gln Asn Ser Ser Tyr Gln 
        755                 760                 765             


Tyr Asp Gly Met Asp Ile Ser Asn Leu Ala Val Asp Phe Ala Val Val 
    770                 775                 780                 


Trp Asn Gly Asn Phe Ile Ile Asp Asn Pro Gln Asp Leu Lys Val His 
785                 790                 795                 800 


Leu Tyr Lys Cys Ala Ala Gln Arg Glu Ser Cys Gly Leu Cys Leu Lys 
                805                 810                 815     


Ala Asp Arg Lys Phe Glu Cys Gly Trp Cys Ser Gly Glu Arg Arg Cys 
            820                 825                 830         


Thr Leu His Gln His Cys Thr Ser Pro Ser Ser Pro Trp Leu Asp Trp 
        835                 840                 845             


Ser Ser His Asn Val Lys Cys Ser Asn Pro Gln Ile Thr Glu Ile Leu 
    850                 855                 860                 


Thr Val Ser Gly Pro Pro Glu Gly Gly Thr Arg Val Thr Ile His Gly 
865                 870                 875                 880 


Val Asn Leu Gly Leu Asp Phe Ser Glu Ile Ala His His Val Gln Val 
                885                 890                 895     


Ala Gly Val Pro Cys Thr Pro Leu Pro Gly Glu Tyr Ile Ile Ala Glu 
            900                 905                 910         


Gln Ile Val Cys Glu Met Gly His Ala Leu Val Gly Thr Thr Ser Gly 
        915                 920                 925             


Pro Val Arg Leu Cys Ile Gly Glu Cys Lys Pro Glu Phe Met Thr Lys 
    930                 935                 940                 


Ser His Gln Gln Tyr Thr Phe Val Asn Pro Ser Val Leu Ser Leu Asn 
945                 950                 955                 960 


Pro Ile Arg Gly Pro Glu Ser Gly Gly Thr Met Val Thr Ile Thr Gly 
                965                 970                 975     


His Tyr Leu Gly Ala Gly Ser Ser Val Ala Val Tyr Leu Gly Asn Gln 
            980                 985                 990         


Thr Cys Glu Phe Tyr Gly Arg Ser  Met Ser Glu Ile Val  Cys Val Ser 
        995                 1000                 1005             


Pro Pro  Ser Ser Asn Gly Leu  Gly Pro Val Pro Val  Ser Val Ser 
    1010                 1015                 1020             


Val Asp  Arg Ala His Val Asp  Ser Asn Leu Gln Phe  Glu Tyr Ile 
    1025                 1030                 1035             


Asp Asp  Pro Arg Val Gln Arg  Ile Glu Pro Glu Trp  Ser Ile Ala 
    1040                 1045                 1050             


Ser Gly  His Thr Pro Leu Thr  Ile Thr Gly Phe Asn  Leu Asp Val 
    1055                 1060                 1065             


Ile Gln  Glu Pro Arg Ile Arg  Val Lys Phe Asn Gly  Lys Glu Ser 
    1070                 1075                 1080             


Val Asn  Val Cys Lys Val Val  Asn Thr Thr Thr Leu  Thr Cys Leu 
    1085                 1090                 1095             


Ala Pro  Ser Leu Thr Thr Asp  Tyr Arg Pro Gly Leu  Asp Thr Val 
    1100                 1105                 1110             


Glu Arg  Pro Asp Glu Phe Gly  Phe Val Phe Asn Asn  Val Gln Ser 
    1115                 1120                 1125             


Leu Leu  Ile Tyr Asn Asp Thr  Lys Phe Ile Tyr Tyr  Pro Asn Pro 
    1130                 1135                 1140             


Thr Phe  Glu Leu Leu Ser Pro  Thr Gly Val Leu Asp  Gln Lys Pro 
    1145                 1150                 1155             


Gly Ser  Pro Ile Ile Leu Lys  Gly Lys Asn Leu Cys  Pro Pro Ala 
    1160                 1165                 1170             


Ser Gly  Gly Ala Lys Leu Asn  Tyr Thr Val Leu Ile  Gly Glu Thr 
    1175                 1180                 1185             


Pro Cys  Ala Val Thr Val Ser  Glu Thr Gln Leu Leu  Cys Glu Pro 
    1190                 1195                 1200             


Pro Asn  Leu Thr Gly Gln His  Lys Val Met Val His  Val Gly Gly 
    1205                 1210                 1215             


Met Val  Phe Ser Pro Gly Ser  Val Ser Val Ile Ser  Asp Ser Leu 
    1220                 1225                 1230             


Leu Thr  Leu Pro Ala Ile Val  Ser Ile Ala Ala Gly  Gly Ser Leu 
    1235                 1240                 1245             


Leu Leu  Ile Ile Val Ile Ile  Val Leu Ile Ala Tyr  Lys Arg Lys 
    1250                 1255                 1260             


Ser Arg  Glu Asn Asp Leu Thr  Leu Lys Arg Leu Gln  Met Gln Met 
    1265                 1270                 1275             


Asp Asn  Leu Glu Ser Arg Val  Ala Leu Glu Cys Lys  Glu Ala Phe 
    1280                 1285                 1290             


Ala Glu  Leu Gln Thr Asp Ile  Asn Glu Leu Thr Ser  Asp Leu Asp 
    1295                 1300                 1305             


Arg Ser  Gly Ile Pro Tyr Leu  Asp Tyr Arg Thr Tyr  Ala Met Arg 
    1310                 1315                 1320             


Val Leu  Phe Pro Gly Ile Glu  Asp His Pro Val Leu  Arg Glu Leu 
    1325                 1330                 1335             


Glu Val  Gln Gly Asn Gly Gln  Gln His Val Glu Lys  Ala Leu Lys 
    1340                 1345                 1350             


Leu Phe  Ala Gln Leu Ile Asn  Asn Lys Val Phe Leu  Leu Thr Phe 
    1355                 1360                 1365             


Ile Arg  Thr Leu Glu Leu Gln  Arg Ser Phe Ser Met  Arg Asp Arg 
    1370                 1375                 1380             


Gly Asn  Val Ala Ser Leu Ile  Met Thr Gly Leu Gln  Gly Arg Leu 
    1385                 1390                 1395             


Glu Tyr  Ala Thr Asp Val Leu  Lys Gln Leu Leu Ser  Asp Leu Ile 
    1400                 1405                 1410             


Asp Lys  Asn Leu Glu Asn Lys  Asn His Pro Lys Leu  Leu Leu Arg 
    1415                 1420                 1425             


Arg Thr  Glu Ser Val Ala Glu  Lys Met Leu Thr Asn  Trp Phe Ala 
    1430                 1435                 1440             


Phe Leu  Leu His Lys Phe Leu  Lys Glu Cys Ala Gly  Glu Pro Leu 
    1445                 1450                 1455             


Phe Met  Leu Tyr Cys Ala Ile  Lys Gln Gln Met Glu  Lys Gly Pro 
    1460                 1465                 1470             


Ile Asp  Ala Ile Thr Gly Glu  Ala Arg Tyr Ser Leu  Ser Glu Asp 
    1475                 1480                 1485             


Lys Leu  Ile Arg Gln Gln Ile  Glu Tyr Lys Thr Leu  Ile Leu Asn 
    1490                 1495                 1500             


Cys Val  Asn Pro Asp Asn Glu  Asn Ser Pro Glu Ile  Pro Val Lys 
    1505                 1510                 1515             


Val Leu  Asn Cys Asp Thr Ile  Thr Gln Val Lys Glu  Lys Ile Leu 
    1520                 1525                 1530             


Asp Ala  Val Tyr Lys Asn Val  Pro Tyr Ser Gln Arg  Pro Arg Ala 
    1535                 1540                 1545             


Val Asp  Met Asp Leu Glu Trp  Arg Gln Gly Arg Ile  Ala Arg Val 
    1550                 1555                 1560             


Val Leu  Gln Asp Glu Asp Ile  Thr Thr Lys Ile Glu  Gly Asp Trp 
    1565                 1570                 1575             


Lys Arg  Leu Asn Thr Leu Met  His Tyr Gln Val Ser  Asp Arg Ser 
    1580                 1585                 1590             


Val Val  Ala Leu Val Pro Lys  Gln Thr Ser Ser Tyr  Asn Ile Pro 
    1595                 1600                 1605             


Ala Ser  Ala Ser Ile Ser Arg  Thr Ser Ile Ser Arg  Tyr Asp Ser 
    1610                 1615                 1620             


Ser Phe  Arg Tyr Thr Gly Ser  Pro Asp Ser Leu Arg  Ser Arg Ala 
    1625                 1630                 1635             


Pro Met  Ile Thr Pro Asp Leu  Glu Ser Gly Val Lys  Val Trp His 
    1640                 1645                 1650             


Leu Val  Lys Asn His Asp His  Gly Asp Gln Lys Glu  Gly Asp Arg 
    1655                 1660                 1665             


Gly Ser  Lys Met Val Ser Glu  Ile Tyr Leu Thr Arg  Leu Leu Ala 
    1670                 1675                 1680             


Thr Lys  Gly Thr Leu Gln Lys  Phe Val Asp Asp Leu  Phe Glu Thr 
    1685                 1690                 1695             


Leu Phe  Ser Thr Val His Arg  Gly Ser Ala Leu Pro  Leu Ala Ile 
    1700                 1705                 1710             


Lys Tyr  Met Phe Asp Phe Leu  Asp Glu Gln Ala Asp  Arg His Ser 
    1715                 1720                 1725             


Ile His  Asp Thr Asp Val Arg  His Thr Trp Lys Ser  Asn Cys Leu 
    1730                 1735                 1740             


Pro Leu  Arg Phe Trp Val Asn  Val Ile Lys Asn Pro  Gln Phe Val 
    1745                 1750                 1755             


Phe Asp  Ile His Lys Gly Ser  Ile Thr Asp Ala Cys  Leu Ser Val 
    1760                 1765                 1770             


Val Ala  Gln Thr Phe Met Asp  Ser Cys Ser Thr Ser  Glu His Arg 
    1775                 1780                 1785             


Leu Gly  Lys Asp Ser Pro Ser  Asn Lys Leu Leu Tyr  Ala Lys Asp 
    1790                 1795                 1800             


Ile Pro  Ser Tyr Lys Ser Trp  Val Glu Arg Tyr Tyr  Ala Asp Ile 
    1805                 1810                 1815             


Ala Lys  Leu Pro Ala Ile Ser  Asp Gln Asp Met Asn  Ala Tyr Leu 
    1820                 1825                 1830             


Ala Glu  Gln Ser Arg Leu His  Ala Val Glu Phe Asn  Met Leu Ser 
    1835                 1840                 1845             


Ala Leu  Asn Glu Ile Tyr Ser  Tyr Val Ser Lys Tyr  Ser Glu Glu 
    1850                 1855                 1860             


Leu Ile  Gly Ala Leu Glu Gln  Asp Glu Gln Ala Arg  Arg Gln Arg 
    1865                 1870                 1875             


Leu Ala  Tyr Lys Val Glu Gln  Leu Ile Asn Ala Met  Ser Ile Glu 
    1880                 1885                 1890             


Ser 
    


<210>  5131
<211>  523
<212>  PRT
<213>  Homo sapiens

<400>  5131

Met Val Pro Pro Arg Arg His Arg Gly Ala Gly Arg Pro Gly Val Leu 
1               5                   10                  15      


Ser Ser Ser Pro Pro Phe Arg Leu Arg Ser Ala Lys Phe Ser Gly Ile 
            20                  25                  30          


Ala Leu Glu Asp Leu Arg Arg Ala Leu Lys Thr Arg Leu Gln Met Val 
        35                  40                  45              


Cys Val Phe Val Met Asn Arg Met Asn Ser Gln Asn Ser Gly Phe Thr 
    50                  55                  60                  


Gln Arg Arg Arg Met Ala Leu Gly Ile Val Ile Leu Leu Leu Val Asp 
65                  70                  75                  80  


Val Ile Trp Val Ala Ser Ser Glu Leu Thr Ser Tyr Val Phe Thr Gln 
                85                  90                  95      


Tyr Asn Lys Pro Phe Phe Ser Thr Phe Ala Lys Thr Ser Met Phe Val 
            100                 105                 110         


Leu Tyr Leu Leu Gly Phe Ile Ile Trp Lys Pro Trp Arg Gln Gln Cys 
        115                 120                 125             


Thr Arg Gly Leu Arg Gly Lys His Ala Ala Phe Phe Ala Asp Ala Glu 
    130                 135                 140                 


Gly Tyr Phe Ala Ala Cys Thr Thr Asp Thr Thr Met Asn Ser Ser Leu 
145                 150                 155                 160 


Ser Glu Pro Leu Tyr Val Pro Val Lys Phe His Asp Leu Pro Ser Glu 
                165                 170                 175     


Lys Pro Glu Ser Thr Asn Ile Asp Thr Glu Lys Thr Pro Lys Lys Ser 
            180                 185                 190         


Arg Val Arg Phe Ser Asn Ile Met Glu Ile Arg Gln Leu Pro Ser Ser 
        195                 200                 205             


His Ala Leu Glu Ala Lys Leu Ser Arg Met Ser Tyr Pro Val Lys Glu 
    210                 215                 220                 


Gln Glu Ser Ile Leu Lys Thr Val Gly Lys Leu Thr Ala Thr Gln Val 
225                 230                 235                 240 


Ala Lys Ile Ser Phe Phe Phe Cys Phe Val Trp Phe Leu Ala Asn Leu 
                245                 250                 255     


Ser Tyr Gln Glu Ala Leu Ser Asp Thr Gln Val Ala Ile Val Asn Ile 
            260                 265                 270         


Leu Ser Ser Thr Ser Gly Leu Phe Thr Leu Ile Leu Ala Ala Val Phe 
        275                 280                 285             


Pro Ser Asn Ser Gly Asp Arg Phe Thr Leu Ser Lys Leu Leu Ala Val 
    290                 295                 300                 


Ile Leu Ser Ile Gly Gly Val Val Leu Val Asn Leu Ala Gly Ser Glu 
305                 310                 315                 320 


Lys Pro Ala Gly Arg Asp Thr Val Gly Ser Ile Trp Ser Leu Ala Gly 
                325                 330                 335     


Ala Met Leu Tyr Ala Val Tyr Ile Val Met Ile Lys Arg Lys Val Asp 
            340                 345                 350         


Arg Glu Asp Lys Leu Asp Ile Pro Met Phe Phe Gly Phe Val Gly Leu 
        355                 360                 365             


Phe Asn Leu Leu Leu Leu Trp Pro Gly Phe Phe Leu Leu His Tyr Thr 
    370                 375                 380                 


Gly Phe Glu Asp Phe Glu Phe Pro Asn Lys Val Val Leu Met Cys Ile 
385                 390                 395                 400 


Ile Ile Asn Gly Leu Ile Gly Thr Val Leu Ser Glu Phe Leu Trp Leu 
                405                 410                 415     


Trp Gly Cys Phe Leu Thr Ser Ser Leu Ile Gly Thr Leu Ala Leu Ser 
            420                 425                 430         


Leu Thr Ile Pro Leu Ser Ile Ile Ala Asp Met Cys Met Gln Lys Val 
        435                 440                 445             


Gln Phe Ser Trp Leu Phe Phe Ala Gly Ala Ile Pro Val Phe Phe Ser 
    450                 455                 460                 


Phe Phe Ile Val Thr Leu Leu Cys His Tyr Asn Asn Trp Asp Pro Val 
465                 470                 475                 480 


Met Val Gly Ile Arg Arg Ile Phe Ala Phe Ile Cys Arg Lys His Arg 
                485                 490                 495     


Ile Gln Arg Val Pro Glu Asp Ser Glu Gln Cys Glu Ser Leu Ile Ser 
            500                 505                 510         


Met His Ser Val Ser Gln Glu Asp Gly Ala Ser 
        515                 520             


<210>  5132
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  5132

Met Ala Asp Ser Ala Gln Ala Gln Lys Leu Val Tyr Leu Val Thr Gly 
1               5                   10                  15      


Gly Cys Gly Phe Leu Gly Glu His Val Val Arg Met Leu Leu Gln Arg 
            20                  25                  30          


Glu Pro Arg Leu Gly Glu Leu Arg Val Phe Asp Gln His Leu Gly Pro 
        35                  40                  45              


Trp Leu Glu Glu Leu Lys Thr Gly Pro Val Arg Val Thr Ala Ile Gln 
    50                  55                  60                  


Gly Asp Val Thr Gln Ala His Glu Val Ala Ala Ala Val Ala Gly Ala 
65                  70                  75                  80  


His Val Val Ile His Thr Ala Gly Leu Val Asp Val Phe Gly Arg Ala 
                85                  90                  95      


Ser Pro Lys Thr Ile His Glu Val Asn Val Gln Gly Thr Arg Asn Val 
            100                 105                 110         


Ile Glu Ala Cys Val Gln Thr Gly Thr Arg Phe Leu Val Tyr Thr Ser 
        115                 120                 125             


Ser Met Glu Val Val Gly Pro Asn Thr Lys Gly His Pro Phe Tyr Arg 
    130                 135                 140                 


Gly Asn Glu Asp Thr Pro Tyr Glu Ala Val His Arg His Pro Tyr Pro 
145                 150                 155                 160 


Cys Ser Lys Ala Leu Ala Glu Trp Leu Val Leu Glu Ala Asn Gly Arg 
                165                 170                 175     


Lys Val Arg Gly Gly Leu Pro Leu Val Thr Cys Ala Leu Arg Pro Thr 
            180                 185                 190         


Gly Ile Tyr Gly Glu Gly His Gln Ile Met Arg Asp Phe Tyr Arg Gln 
        195                 200                 205             


Gly Leu Arg Leu Gly Gly Trp Leu Phe Arg Ala Ile Pro Ala Ser Val 
    210                 215                 220                 


Glu His Gly Arg Val Tyr Val Gly Asn Val Ala Trp Met His Val Leu 
225                 230                 235                 240 


Ala Ala Arg Glu Leu Glu Gln Arg Ala Thr Leu Met Gly Gly Gln Val 
                245                 250                 255     


Tyr Phe Cys Tyr Asp Gly Ser Pro Tyr Arg Ser Tyr Glu Asp Phe Asn 
            260                 265                 270         


Met Glu Phe Leu Gly Pro Cys Gly Leu Arg Leu Val Gly Ala Arg Pro 
        275                 280                 285             


Leu Leu Pro Tyr Trp Leu Leu Val Phe Leu Ala Ala Leu Asn Ala Leu 
    290                 295                 300                 


Leu Gln Trp Leu Leu Arg Pro Leu Val Leu Tyr Ala Pro Leu Leu Asn 
305                 310                 315                 320 


Pro Tyr Thr Leu Ala Val Ala Asn Thr Thr Phe Thr Val Ser Thr Asp 
                325                 330                 335     


Lys Ala Gln Arg His Phe Gly Tyr Glu Pro Leu Phe Ser Trp Glu Asp 
            340                 345                 350         


Ser Arg Thr Arg Thr Ile Leu Trp Val Gln Ala Ala Thr Gly Ser Ala 
        355                 360                 365             


Gln 
    


<210>  5133
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  5133

Met Ala Ala Ala Ala Ala Thr Lys Ile Leu Leu Cys Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Ser Gly Trp Ser Arg Ala Gly Arg Ala Asp Pro His Ser 
            20                  25                  30          


Leu Cys Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg Pro Gly Pro Arg 
        35                  40                  45              


Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr Phe Leu His Tyr 
    50                  55                  60                  


Asp Cys Gly Asn Lys Thr Val Thr Pro Val Ser Pro Leu Gly Lys Lys 
65                  70                  75                  80  


Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn Pro Val Leu Arg Glu 
                85                  90                  95      


Val Val Asp Ile Leu Thr Glu Gln Leu Arg Asp Ile Gln Leu Glu Asn 
            100                 105                 110         


Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg Met Ser Cys Glu 
        115                 120                 125             


Gln Lys Ala Glu Gly His Ser Ser Gly Ser Trp Gln Phe Ser Phe Asp 
    130                 135                 140                 


Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Lys Arg Met Trp Thr Thr 
145                 150                 155                 160 


Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp Glu Asn Asp Lys 
                165                 170                 175     


Val Val Ala Met Ser Phe His Tyr Phe Ser Met Gly Asp Cys Ile Gly 
            180                 185                 190         


Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr Leu Glu Pro Ser 
        195                 200                 205             


Ala Gly Ala Pro Leu Ala Met Ser Ser Gly Thr Thr Gln Leu Arg Ala 
    210                 215                 220                 


Thr Ala Thr Thr Leu Ile Leu Cys Cys Leu Leu Ile Ile Leu Pro Cys 
225                 230                 235                 240 


Phe Ile Leu Pro Gly Ile 
                245     


<210>  5134
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  5134

Met Ala Asp Gln Arg Gln Arg Ser Leu Ser Thr Ser Gly Glu Ser Leu 
1               5                   10                  15      


Tyr His Val Leu Gly Leu Asp Lys Asn Ala Thr Ser Asp Asp Ile Lys 
            20                  25                  30          


Lys Ser Tyr Arg Lys Leu Ala Leu Lys Tyr His Pro Asp Lys Asn Pro 
        35                  40                  45              


Asp Asn Pro Glu Ala Ala Asp Lys Phe Lys Glu Ile Asn Asn Ala His 
    50                  55                  60                  


Ala Ile Leu Thr Asp Ala Thr Lys Arg Asn Ile Tyr Asp Lys Tyr Gly 
65                  70                  75                  80  


Ser Leu Gly Leu Tyr Val Ala Glu Gln Phe Gly Glu Glu Asn Val Asn 
                85                  90                  95      


Thr Tyr Phe Val Leu Ser Ser Trp Trp Ala Lys Ala Leu Phe Val Phe 
            100                 105                 110         


Cys Gly Leu Leu Thr Cys Cys Tyr Cys Cys Cys Cys Leu Cys Cys Cys 
        115                 120                 125             


Phe Asn Cys Cys Cys Gly Lys Cys Lys Pro Lys Ala Pro Glu Gly Glu 
    130                 135                 140                 


Glu Thr Glu Phe Tyr Val Ser Pro Glu Asp Leu Glu Ala Gln Leu Gln 
145                 150                 155                 160 


Ser Asp Glu Arg Glu Ala Thr Asp Thr Pro Ile Val Ile Gln Pro Ala 
                165                 170                 175     


Ser Ala Thr Glu Thr Thr Gln Leu Thr Ala Asp Ser His Pro Ser Tyr 
            180                 185                 190         


His Thr Asp Gly Phe Asn 
        195             


<210>  5135
<211>  813
<212>  PRT
<213>  Homo sapiens

<400>  5135

Met Gly Trp Arg Pro Arg Arg Ala Arg Gly Thr Pro Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Trp Pro Val Pro Gly Ala Gly Val Leu Gln 
            20                  25                  30          


Gly His Ile Pro Gly Gln Pro Val Thr Pro His Trp Val Leu Asp Gly 
        35                  40                  45              


Gln Pro Trp Arg Thr Val Ser Leu Glu Glu Pro Val Ser Lys Pro Asp 
    50                  55                  60                  


Met Gly Leu Val Ala Leu Glu Ala Glu Gly Gln Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Leu Glu Lys Asn His Arg Leu Leu Ala Pro Gly Tyr Ile Glu Thr His 
                85                  90                  95      


Tyr Gly Pro Asp Gly Gln Pro Val Val Leu Ala Pro Asn His Thr Asp 
            100                 105                 110         


His Cys His Tyr Gln Gly Arg Val Arg Gly Phe Pro Asp Ser Trp Val 
        115                 120                 125             


Val Leu Cys Thr Cys Ser Gly Met Ser Gly Leu Ile Thr Leu Ser Arg 
    130                 135                 140                 


Asn Ala Ser Tyr Tyr Leu Arg Pro Trp Pro Pro Arg Gly Ser Lys Asp 
145                 150                 155                 160 


Phe Ser Thr His Glu Ile Phe Arg Met Glu Gln Leu Leu Thr Trp Lys 
                165                 170                 175     


Gly Thr Cys Gly His Arg Asp Pro Gly Asn Lys Ala Gly Met Thr Ser 
            180                 185                 190         


Leu Pro Gly Gly Pro Gln Ser Arg Gly Arg Arg Glu Ala Arg Arg Thr 
        195                 200                 205             


Arg Lys Tyr Leu Glu Leu Tyr Ile Val Ala Asp His Thr Leu Phe Leu 
    210                 215                 220                 


Thr Arg His Arg Asn Leu Asn His Thr Lys Gln Arg Leu Leu Glu Val 
225                 230                 235                 240 


Ala Asn Tyr Val Asp Gln Leu Leu Arg Thr Leu Asp Ile Gln Val Ala 
                245                 250                 255     


Leu Thr Gly Leu Glu Val Trp Thr Glu Arg Asp Arg Ser Arg Val Thr 
            260                 265                 270         


Gln Asp Ala Asn Ala Thr Leu Trp Ala Phe Leu Gln Trp Arg Arg Gly 
        275                 280                 285             


Leu Trp Ala Gln Arg Pro His Asp Ser Ala Gln Leu Leu Thr Gly Arg 
    290                 295                 300                 


Ala Phe Gln Gly Ala Thr Val Gly Leu Ala Pro Val Glu Gly Met Cys 
305                 310                 315                 320 


Arg Ala Glu Ser Ser Gly Gly Val Ser Thr Asp His Ser Glu Leu Pro 
                325                 330                 335     


Ile Gly Ala Ala Ala Thr Met Ala His Glu Ile Gly His Ser Leu Gly 
            340                 345                 350         


Leu Ser His Asp Pro Asp Gly Cys Cys Val Glu Ala Ala Ala Glu Ser 
        355                 360                 365             


Gly Gly Cys Val Met Ala Ala Ala Thr Gly His Pro Phe Pro Arg Val 
    370                 375                 380                 


Phe Ser Ala Cys Ser Arg Arg Gln Leu Arg Ala Phe Phe Arg Lys Gly 
385                 390                 395                 400 


Gly Gly Ala Cys Leu Ser Asn Ala Pro Asp Pro Gly Leu Pro Val Pro 
                405                 410                 415     


Pro Ala Leu Cys Gly Asn Gly Phe Val Glu Ala Gly Glu Glu Cys Asp 
            420                 425                 430         


Cys Gly Pro Gly Gln Glu Cys Arg Asp Leu Cys Cys Phe Ala His Asn 
        435                 440                 445             


Cys Ser Leu Arg Pro Gly Ala Gln Cys Ala His Gly Asp Cys Cys Val 
    450                 455                 460                 


Arg Cys Leu Leu Lys Pro Ala Gly Ala Leu Cys Arg Gln Ala Met Gly 
465                 470                 475                 480 


Asp Cys Asp Leu Pro Glu Phe Cys Thr Gly Thr Ser Ser His Cys Pro 
                485                 490                 495     


Pro Asp Val Tyr Leu Leu Asp Gly Ser Pro Cys Ala Arg Gly Ser Gly 
            500                 505                 510         


Tyr Cys Trp Asp Gly Ala Cys Pro Thr Leu Glu Gln Gln Cys Gln Gln 
        515                 520                 525             


Leu Trp Gly Pro Gly Ser His Pro Ala Pro Glu Ala Cys Phe Gln Val 
    530                 535                 540                 


Val Asn Ser Ala Gly Asp Ala His Gly Asn Cys Gly Gln Asp Ser Glu 
545                 550                 555                 560 


Gly His Phe Leu Pro Cys Ala Gly Arg Asp Ala Leu Cys Gly Lys Leu 
                565                 570                 575     


Gln Cys Gln Gly Gly Lys Pro Ser Leu Leu Ala Pro His Met Val Pro 
            580                 585                 590         


Val Asp Ser Thr Val His Leu Asp Gly Gln Glu Val Thr Cys Arg Gly 
        595                 600                 605             


Ala Leu Ala Leu Pro Ser Ala Gln Leu Asp Leu Leu Gly Leu Gly Leu 
    610                 615                 620                 


Val Glu Pro Gly Thr Gln Cys Gly Pro Arg Met Val Cys Gln Ser Arg 
625                 630                 635                 640 


Arg Cys Arg Lys Asn Ala Phe Gln Glu Leu Gln Arg Cys Leu Thr Ala 
                645                 650                 655     


Cys His Ser His Gly Val Cys Asn Ser Asn His Asn Cys His Cys Ala 
            660                 665                 670         


Pro Gly Trp Ala Pro Pro Phe Cys Asp Lys Pro Gly Phe Gly Gly Ser 
        675                 680                 685             


Met Asp Ser Gly Pro Val Gln Ala Glu Asn His Asp Thr Phe Leu Leu 
    690                 695                 700                 


Ala Met Leu Leu Ser Val Leu Leu Pro Leu Leu Pro Gly Ala Gly Leu 
705                 710                 715                 720 


Ala Trp Cys Cys Tyr Arg Leu Pro Gly Ala His Leu Gln Arg Cys Ser 
                725                 730                 735     


Trp Gly Cys Arg Arg Asp Pro Ala Cys Ser Gly Pro Lys Asp Gly Pro 
            740                 745                 750         


His Arg Asp His Pro Leu Gly Gly Val His Pro Met Glu Leu Gly Pro 
        755                 760                 765             


Thr Ala Thr Gly Gln Pro Trp Pro Leu Asp Pro Glu Asn Ser His Glu 
    770                 775                 780                 


Pro Ser Ser His Pro Glu Lys Pro Leu Pro Ala Val Ser Pro Asp Pro 
785                 790                 795                 800 


Gln Ala Asp Gln Val Gln Met Pro Arg Ser Cys Leu Trp 
                805                 810             


<210>  5136
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  5136

Met Ala Trp Ala Ser Arg Leu Gly Leu Leu Leu Ala Leu Leu Leu Pro 
1               5                   10                  15      


Val Val Gly Ala Ser Thr Pro Gly Thr Val Val Arg Leu Asn Lys Ala 
            20                  25                  30          


Ala Leu Ser Tyr Val Ser Glu Ile Gly Lys Ala Pro Leu Gln Arg Ala 
        35                  40                  45              


Leu Gln Val Thr Val Pro His Phe Leu Asp Trp Ser Gly Glu Ala Leu 
    50                  55                  60                  


Gln Pro Thr Arg Ile Arg Ile Leu Asn Val His Val Pro Arg Leu His 
65                  70                  75                  80  


Leu Lys Phe Ile Ala Gly Phe Gly Val Arg Leu Leu Ala Ala Ala Asn 
                85                  90                  95      


Phe Thr Phe Lys Val Phe Arg Ala Pro Glu Pro Leu Glu Leu Thr Leu 
            100                 105                 110         


Pro Val Glu Leu Leu Ala Asp Thr Arg Val Thr Gln Ser Ser Ile Arg 
        115                 120                 125             


Thr Pro Val Val Ser Ile Ser Ala Cys Ser Leu Phe Ser Gly His Ala 
    130                 135                 140                 


Asn Glu Phe Asp Gly Ser Asn Ser Thr Ser His Ala Leu Leu Val Leu 
145                 150                 155                 160 


Val Gln Lys His Ile Lys Ala Val Leu Ser Asn Lys Leu Cys Leu Ser 
                165                 170                 175     


Ile Ser Asn Leu Val Gln Gly Val Asn Val His Leu Gly Thr Leu Ile 
            180                 185                 190         


Gly Leu Asn Pro Val Gly Pro Glu Ser Gln Ile Arg Tyr Ser Met Val 
        195                 200                 205             


Ser Val Pro Thr Val Thr Ser Asp Tyr Ile Ser Leu Glu Val Asn Ala 
    210                 215                 220                 


Val Leu Phe Leu Leu Gly Lys Pro Ile Ile Leu Pro Thr Asp Ala Thr 
225                 230                 235                 240 


Pro Phe Val Leu Pro Arg His Val Gly Thr Glu Gly Ser Met Ala Thr 
                245                 250                 255     


Val Gly Leu Ser Gln Gln Leu Phe Asp Ser Ala Leu Leu Leu Leu Gln 
            260                 265                 270         


Lys Ala Gly Ala Leu Asn Leu Asp Ile Thr Gly Gln Leu Arg Ser Asp 
        275                 280                 285             


Asp Asn Leu Leu Asn Thr Ser Ala Leu Gly Arg Leu Ile Pro Glu Val 
    290                 295                 300                 


Ala Arg Gln Phe Pro Glu Pro Met Pro Val Val Leu Lys Val Arg Leu 
305                 310                 315                 320 


Gly Ala Thr Pro Val Ala Met Leu His Thr Asn Asn Ala Thr Leu Arg 
                325                 330                 335     


Leu Gln Pro Phe Val Glu Val Leu Ala Thr Ala Ser Asn Ser Ala Phe 
            340                 345                 350         


Gln Ser Leu Phe Ser Leu Asp Val Val Val Asn Leu Arg Leu Gln Leu 
        355                 360                 365             


Ser Val Ser Lys Val Lys Leu Gln Gly Thr Thr Ser Val Leu Gly Asp 
    370                 375                 380                 


Val Gln Leu Thr Val Ala Ser Ser Asn Val Gly Phe Ile Asp Thr Asp 
385                 390                 395                 400 


Gln Val Arg Thr Leu Met Gly Thr Val Phe Glu Lys Pro Leu Leu Asp 
                405                 410                 415     


His Leu Asn Ala Leu Leu Ala Met Gly Ile Ala Leu Pro Gly Val Val 
            420                 425                 430         


Asn Leu His Tyr Val Ala Pro Glu Ile Phe Val Tyr Glu Gly Tyr Val 
        435                 440                 445             


Val Ile Ser Ser Gly Leu Phe Tyr Gln Ser 
    450                 455             


<210>  5137
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  5137

Met Ile Ser Pro Asp Pro Arg Pro Ser Pro Gly Leu Ala Arg Trp Ala 
1               5                   10                  15      


Glu Ser Tyr Glu Ala Lys Cys Glu Arg Arg Gln Glu Ile Arg Glu Ser 
            20                  25                  30          


Arg Arg Cys Arg Pro Asn Val Thr Thr Cys Arg Gln Val Gly Lys Thr 
        35                  40                  45              


Leu Arg Ile Gln Gln Arg Glu Gln Leu Gln Arg Ala Arg Leu Gln Gln 
    50                  55                  60                  


Phe Phe Arg Arg Arg Asn Leu Glu Leu Glu Glu Lys Gly Lys Ala Gln 
65                  70                  75                  80  


His Pro Gln Ala Arg Glu Gln Gly Pro Ser Arg Arg Pro Gly Gln Val 
                85                  90                  95      


Thr Val Leu Lys Glu Pro Leu Ser Cys Ala Arg Arg Ile Ser Ser Pro 
            100                 105                 110         


Arg Glu Gln Val Thr Gly Thr Ser Ser Glu Val Phe Pro Ala Gln His 
        115                 120                 125             


Pro Pro Pro Ser Gly Ile Cys Arg Asp Leu Ser Asp His Leu Ser Ser 
    130                 135                 140                 


Gln Ala Gly Gly Leu Pro Pro Gln Asp Thr Pro Ile Lys Lys Pro Pro 
145                 150                 155                 160 


Lys His His Arg Gly Thr Gln Thr Lys Ala Glu Gly Pro Thr Ile Lys 
                165                 170                 175     


Asn Asp Ala Ser Gln Gln Thr Asn Tyr Gly Val Ala Val Leu Asp Lys 
            180                 185                 190         


Glu Ile Ile Gln Leu Ser Asp Tyr Leu Lys Glu Ala Leu Gln Arg Glu 
        195                 200                 205             


Leu Val Leu Lys Gln Lys Met Val Ile Leu Gln Asp Leu Leu Ser Thr 
    210                 215                 220                 


Leu Ile Gln Ala Ser Asp Ser Ser Trp Lys Gly Gln Leu Asn Glu Asp 
225                 230                 235                 240 


Lys Leu Lys Gly Lys Leu Arg Ser Leu Glu Asn Gln Leu Tyr Thr Cys 
                245                 250                 255     


Thr Gln Lys Tyr Ser Pro Trp Gly Met Lys Lys Val Leu Leu Glu Met 
            260                 265                 270         


Glu Asp Gln Lys Asn Ser Tyr Glu Gln Lys Ala Lys Glu Ser Leu Gln 
        275                 280                 285             


Lys Val Leu Glu Glu Lys Met Asn Ala Glu Gln Gln Leu Gln Ser Thr 
    290                 295                 300                 


Gln Arg Ser Leu Ala Leu Ala Glu Gln Lys Cys Glu Glu Trp Arg Ser 
305                 310                 315                 320 


Gln Tyr Glu Ala Leu Lys Glu Asp Trp Arg Thr Leu Gly Thr Gln His 
                325                 330                 335     


Arg Glu Leu Glu Ser Gln Leu His Val Leu Gln Ser Lys Leu Gln Gly 
            340                 345                 350         


Ala Asp Ser Arg Asp Leu Gln Met Asn Gln Ala Leu Arg Phe Leu Glu 
        355                 360                 365             


Asn Glu His Gln Gln Leu Gln Ala Lys Ile Glu Cys Leu Gln Gly Asp 
    370                 375                 380                 


Arg Asp Leu Cys Ser Leu Asp Thr Gln Asp Leu Gln Asp Gln Leu Lys 
385                 390                 395                 400 


Arg Ser Glu Ala Glu Lys Leu Thr Leu Val Thr Arg Val Gln Gln Leu 
                405                 410                 415     


Gln Gly Leu Leu Gln Asn Gln Ser Leu Gln Leu Gln Glu Gln Glu Lys 
            420                 425                 430         


Leu Leu Thr Lys Lys Asp Gln Ala Leu Pro Val Trp Ser Pro Lys Ser 
        435                 440                 445             


Phe Pro Asn Glu Val Glu Pro Glu Gly Thr Gly Lys Glu Lys Asp Trp 
    450                 455                 460                 


Asp Leu Arg Asp Gln Leu Gln Lys Lys Thr Leu Gln Leu Gln Ala Lys 
465                 470                 475                 480 


Glu Lys Glu Cys Arg Glu Leu His Ser Glu Leu Asp Asn Leu Ser Asp 
                485                 490                 495     


Glu Tyr Leu Ser Cys Leu Arg Lys Leu Gln His Cys Arg Glu Glu Leu 
            500                 505                 510         


Asn Gln Ser Gln Gln Leu Pro Pro Arg Arg Gln Cys Gly Arg Trp Leu 
        515                 520                 525             


Pro Val Leu Met Val Val Ile Ala Ala Ala Leu Ala Val Phe Leu Ala 
    530                 535                 540                 


Asn Lys Asp Asn Leu Met Ile 
545                 550     


<210>  5138
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  5138

Met Val Ser Trp Met Ile Cys Arg Leu Val Val Leu Val Phe Gly Met 
1               5                   10                  15      


Leu Cys Pro Ala Tyr Ala Ser Tyr Lys Ala Val Lys Thr Lys Asn Ile 
            20                  25                  30          


Arg Glu Tyr Val Arg Trp Met Met Tyr Trp Ile Val Phe Ala Leu Phe 
        35                  40                  45              


Met Ala Ala Glu Ile Val Thr Asp Ile Phe Ile Ser Trp Phe Pro Phe 
    50                  55                  60                  


Tyr Tyr Glu Ile Lys Met Ala Phe Val Leu Trp Leu Leu Ser Pro Tyr 
65                  70                  75                  80  


Thr Lys Gly Ala Ser Leu Leu Tyr Arg Lys Phe Val His Pro Ser Leu 
                85                  90                  95      


Ser Arg His Glu Lys Glu Ile Asp Ala Tyr Ile Val Gln Ala Lys Glu 
            100                 105                 110         


Arg Ser Tyr Glu Thr Val Leu Ser Phe Gly Lys Arg Gly Leu Asn Ile 
        115                 120                 125             


Ala Ala Ser Ala Ala Val Gln Ala Ala Thr Lys Ser Gln Gly Ala Leu 
    130                 135                 140                 


Ala Gly Arg Leu Arg Ser Phe Ser Met Gln Asp Leu Arg Ser Ile Ser 
145                 150                 155                 160 


Asp Ala Pro Ala Pro Ala Tyr His Asp Pro Leu Tyr Leu Glu Asp Gln 
                165                 170                 175     


Val Ser His Arg Arg Pro Pro Ile Gly Tyr Arg Ala Gly Gly Leu Gln 
            180                 185                 190         


Asp Ser Asp Thr Glu Asp Glu Cys Trp Ser Asp Thr Glu Ala Val Pro 
        195                 200                 205             


Arg Ala Pro Ala Arg Pro Arg Glu Lys Pro Leu Ile Arg Ser Gln Ser 
    210                 215                 220                 


Leu Arg Val Val Lys Arg Lys Pro Pro Val Arg Glu Gly Thr Ser Arg 
225                 230                 235                 240 


Ser Leu Lys Val Arg Thr Arg Lys Lys Thr Val Pro Ser Asp Val Asp 
                245                 250                 255     


Ser 
    


<210>  5139
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  5139

Met Ile Phe Leu Leu Leu Met Leu Ser Leu Glu Leu Gln Leu His Gln 
1               5                   10                  15      


Ile Ala Ala Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile 
            20                  25                  30          


Glu His Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser 
        35                  40                  45              


His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp 
                85                  90                  95      


Glu Gly Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr 
        115                 120                 125             


His Ile Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln 
    130                 135                 140                 


Ala Thr Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys 
            180                 185                 190         


Val Phe Trp Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp 
        195                 200                 205             


Leu Gln Ser Gln Met Glu Pro Arg Thr His Pro Thr Trp Leu Leu His 
    210                 215                 220                 


Ile Phe Ile Pro Phe Cys Ile Ile Ala Phe Ile Phe Ile Ala Thr Val 
225                 230                 235                 240 


Ile Ala Leu Arg Lys Gln Leu Cys Gln Lys Leu Tyr Ser Ser Lys Asp 
                245                 250                 255     


Thr Thr Lys Arg Pro Val Thr Thr Thr Lys Arg Glu Val Asn Ser Ala 
            260                 265                 270         


Ile 
    


<210>  5140
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  5140

Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 
1               5                   10                  15      


Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln 
            20                  25                  30          


Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu 
        35                  40                  45              


Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 
    50                  55                  60                  


Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala 
65                  70                  75                  80  


Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe 
                85                  90                  95      


Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 
            100                 105                 110         


Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp 
        115                 120                 125             


Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys 
    130                 135                 140                 


Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr 
145                 150                 155                 160 


Val Thr Ile Thr Cys Ser Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val 
                165                 170                 175     


Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr 
            180                 185                 190         


Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Val Leu 
        195                 200                 205             


Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn 
    210                 215                 220                 


Pro Val Leu Gln Gln Asp Ala His Gly Ser Val Thr Ile Thr Gly Gln 
225                 230                 235                 240 


Pro Met Thr Phe Pro Pro Glu Ala Leu Trp Val Thr Val Gly Leu Ser 
                245                 250                 255     


Val Cys Leu Ile Ala Leu Leu Val Ala Leu Ala Phe Val Cys Trp Arg 
            260                 265                 270         


Lys Ile Lys Gln Ser Cys Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln 
        275                 280                 285             


Asp Gly Glu Gly Glu Gly Ser Lys Thr Ala Leu Gln Pro Leu Lys His 
    290                 295                 300                 


Ser Asp Ser Lys Glu Asp Asp Gly Gln Glu Ile Ala 
305                 310                 315     


<210>  5141
<211>  523
<212>  PRT
<213>  Homo sapiens

<400>  5141

Met Ala Gly Val Ser Tyr Ala Ala Pro Trp Trp Val Ser Leu Leu His 
1               5                   10                  15      


Arg Leu Pro His Phe Asp Leu Ser Trp Glu Ala Thr Ser Ser Gln Phe 
            20                  25                  30          


Arg Pro Glu Asp Thr Asp Tyr Gln Gln Ala Leu Leu Leu Leu Gly Ala 
        35                  40                  45              


Ala Ala Leu Ala Cys Leu Ala Leu Asp Leu Leu Phe Leu Leu Phe Tyr 
    50                  55                  60                  


Ser Phe Trp Leu Cys Cys Arg Arg Arg Lys Ser Glu Glu His Leu Asp 
65                  70                  75                  80  


Ala Asp Cys Cys Cys Thr Ala Trp Cys Val Ile Ile Ala Thr Leu Val 
                85                  90                  95      


Cys Ser Ala Gly Ile Ala Val Gly Phe Tyr Gly Asn Gly Glu Thr Ser 
            100                 105                 110         


Asp Gly Ile His Arg Ala Thr Tyr Ser Leu Arg His Ala Asn Arg Thr 
        115                 120                 125             


Val Ala Gly Val Gln Asp Arg Val Trp Asp Thr Ala Val Gly Leu Asn 
    130                 135                 140                 


His Thr Ala Glu Pro Ser Leu Gln Thr Leu Glu Arg Gln Leu Ala Gly 
145                 150                 155                 160 


Arg Pro Glu Pro Leu Arg Ala Val Gln Arg Leu Gln Gly Leu Leu Glu 
                165                 170                 175     


Thr Leu Leu Gly Tyr Thr Ala Ala Ile Pro Phe Trp Arg Asn Thr Ala 
            180                 185                 190         


Val Ser Leu Glu Val Leu Ala Glu Gln Val Asp Leu Tyr Asp Trp Tyr 
        195                 200                 205             


Arg Trp Leu Gly Tyr Leu Gly Leu Leu Leu Leu Asp Val Ile Ile Cys 
    210                 215                 220                 


Leu Leu Val Leu Val Gly Leu Ile Arg Ser Ser Lys Gly Ile Leu Val 
225                 230                 235                 240 


Gly Val Cys Leu Leu Gly Val Leu Ala Leu Val Ile Ser Trp Gly Ala 
                245                 250                 255     


Leu Gly Leu Glu Leu Ala Val Ser Val Gly Ser Ser Asp Phe Cys Val 
            260                 265                 270         


Asp Pro Asp Ala Tyr Val Thr Lys Met Val Glu Glu Tyr Ser Val Leu 
        275                 280                 285             


Ser Gly Asp Ile Leu Gln Tyr Tyr Leu Ala Cys Ser Pro Arg Ala Ala 
    290                 295                 300                 


Asn Pro Phe Gln Gln Lys Leu Ser Gly Ser His Lys Ala Leu Val Glu 
305                 310                 315                 320 


Met Gln Asp Val Val Ala Glu Leu Leu Arg Thr Val Pro Trp Glu Gln 
                325                 330                 335     


Pro Ala Thr Lys Asp Pro Leu Leu Arg Val Gln Glu Val Leu Asn Gly 
            340                 345                 350         


Thr Glu Val Asn Leu Gln His Leu Thr Ala Leu Val Asp Cys Arg Ser 
        355                 360                 365             


Leu His Leu Asp Tyr Val Gln Ala Leu Thr Gly Phe Cys Tyr Asp Gly 
    370                 375                 380                 


Val Glu Gly Leu Ile Tyr Leu Ala Leu Phe Ser Phe Val Thr Ala Leu 
385                 390                 395                 400 


Met Phe Ser Ser Ile Val Cys Ser Val Pro His Thr Trp Gln Gln Lys 
                405                 410                 415     


Arg Gly Pro Asp Glu Asp Gly Glu Glu Glu Ala Ala Pro Gly Pro Arg 
            420                 425                 430         


Gln Ala His Asp Ser Leu Tyr Arg Val His Met Pro Ser Leu Tyr Ser 
        435                 440                 445             


Cys Gly Ser Ser Tyr Gly Ser Glu Thr Ser Ile Pro Ala Ala Ala His 
    450                 455                 460                 


Thr Val Ser Asn Ala Pro Val Thr Glu Tyr Met Ser Gln Asn Ala Asn 
465                 470                 475                 480 


Phe Gln Asn Pro Arg Cys Glu Asn Thr Pro Leu Ile Gly Arg Glu Ser 
                485                 490                 495     


Pro Pro Pro Ser Tyr Thr Ser Ser Met Arg Ala Lys Tyr Leu Ala Thr 
            500                 505                 510         


Ser Gln Pro Arg Pro Asp Ser Ser Gly Ser His 
        515                 520             


<210>  5142
<211>  710
<212>  PRT
<213>  Homo sapiens

<400>  5142

Met Gly Gly Lys Gln Arg Asp Glu Asp Asp Glu Ala Tyr Gly Lys Pro 
1               5                   10                  15      


Val Lys Tyr Asp Pro Ser Phe Arg Gly Pro Ile Lys Asn Arg Ser Cys 
            20                  25                  30          


Thr Asp Val Ile Cys Cys Val Leu Phe Leu Leu Phe Ile Leu Gly Tyr 
        35                  40                  45              


Ile Val Val Gly Ile Val Ala Trp Leu Tyr Gly Asp Pro Arg Gln Val 
    50                  55                  60                  


Leu Tyr Pro Arg Asn Ser Thr Gly Ala Tyr Cys Gly Met Gly Glu Asn 
65                  70                  75                  80  


Lys Asp Lys Pro Tyr Leu Leu Tyr Phe Asn Ile Phe Ser Cys Ile Leu 
                85                  90                  95      


Ser Ser Asn Ile Ile Ser Val Ala Glu Asn Gly Leu Gln Cys Pro Thr 
            100                 105                 110         


Pro Gln Val Cys Val Ser Ser Cys Pro Glu Asp Pro Trp Thr Val Gly 
        115                 120                 125             


Lys Asn Glu Phe Ser Gln Thr Val Gly Glu Val Phe Tyr Thr Lys Asn 
    130                 135                 140                 


Arg Asn Phe Cys Leu Pro Gly Val Pro Trp Asn Met Thr Val Ile Thr 
145                 150                 155                 160 


Ser Leu Gln Gln Glu Leu Cys Pro Ser Phe Leu Leu Pro Ser Ala Pro 
                165                 170                 175     


Ala Leu Gly Arg Cys Phe Pro Trp Thr Asn Val Thr Pro Pro Ala Leu 
            180                 185                 190         


Pro Gly Ile Thr Asn Asp Thr Thr Ile Gln Gln Gly Ile Ser Gly Leu 
        195                 200                 205             


Ile Asp Ser Leu Asn Ala Arg Asp Ile Ser Val Lys Ile Phe Glu Asp 
    210                 215                 220                 


Phe Ala Gln Ser Trp Tyr Trp Ile Leu Val Ala Leu Gly Val Ala Leu 
225                 230                 235                 240 


Val Leu Ser Leu Leu Phe Ile Leu Leu Leu Arg Leu Val Ala Gly Pro 
                245                 250                 255     


Leu Val Leu Val Leu Ile Leu Gly Val Leu Gly Val Leu Ala Tyr Gly 
            260                 265                 270         


Ile Tyr Tyr Cys Trp Glu Glu Tyr Arg Val Leu Arg Asp Lys Gly Ala 
        275                 280                 285             


Ser Ile Ser Gln Leu Gly Phe Thr Thr Asn Leu Ser Ala Tyr Gln Ser 
    290                 295                 300                 


Val Gln Glu Thr Trp Leu Ala Ala Leu Ile Val Leu Ala Val Leu Glu 
305                 310                 315                 320 


Ala Ile Leu Leu Leu Met Leu Ile Phe Leu Arg Gln Arg Ile Arg Ile 
                325                 330                 335     


Ala Ile Ala Leu Leu Lys Glu Ala Ser Lys Ala Val Gly Gln Met Met 
            340                 345                 350         


Ser Thr Met Phe Tyr Pro Leu Val Thr Phe Val Leu Leu Leu Ile Cys 
        355                 360                 365             


Ile Ala Tyr Trp Ala Met Thr Ala Leu Tyr Leu Ala Thr Ser Gly Gln 
    370                 375                 380                 


Pro Gln Tyr Val Leu Trp Ala Ser Asn Ile Ser Ser Pro Gly Cys Glu 
385                 390                 395                 400 


Lys Val Pro Ile Asn Thr Ser Cys Asn Pro Thr Ala His Leu Val Asn 
                405                 410                 415     


Ser Ser Cys Pro Gly Leu Met Cys Val Phe Gln Gly Tyr Ser Ser Lys 
            420                 425                 430         


Gly Leu Ile Gln Arg Ser Val Phe Asn Leu Gln Ile Tyr Gly Val Leu 
        435                 440                 445             


Gly Leu Phe Trp Thr Leu Asn Trp Val Leu Ala Leu Gly Gln Cys Val 
    450                 455                 460                 


Leu Ala Gly Ala Phe Ala Ser Phe Tyr Trp Ala Phe His Lys Pro Gln 
465                 470                 475                 480 


Asp Ile Pro Thr Phe Pro Leu Ile Ser Ala Phe Ile Arg Thr Leu Arg 
                485                 490                 495     


Tyr His Thr Gly Ser Leu Ala Phe Gly Ala Leu Ile Leu Thr Leu Val 
            500                 505                 510         


Gln Ile Ala Arg Val Ile Leu Glu Tyr Ile Asp His Lys Leu Arg Gly 
        515                 520                 525             


Val Gln Asn Pro Val Ala Arg Cys Ile Met Cys Cys Phe Lys Cys Cys 
    530                 535                 540                 


Leu Trp Cys Leu Glu Lys Phe Ile Lys Phe Leu Asn Arg Asn Ala Tyr 
545                 550                 555                 560 


Ile Met Ile Ala Ile Tyr Gly Lys Asn Phe Cys Val Ser Ala Lys Asn 
                565                 570                 575     


Ala Phe Met Leu Leu Met Arg Asn Ile Val Arg Val Val Val Leu Asp 
            580                 585                 590         


Lys Val Thr Asp Leu Leu Leu Phe Phe Gly Lys Leu Leu Val Val Gly 
        595                 600                 605             


Gly Val Gly Val Leu Ser Phe Phe Phe Phe Ser Gly Arg Ile Pro Gly 
    610                 615                 620                 


Leu Gly Lys Asp Phe Lys Ser Pro His Leu Asn Tyr Tyr Trp Leu Pro 
625                 630                 635                 640 


Ile Met Thr Ser Ile Leu Gly Ala Tyr Val Ile Ala Ser Gly Phe Phe 
                645                 650                 655     


Ser Val Phe Gly Met Cys Val Asp Thr Leu Phe Leu Cys Phe Leu Glu 
            660                 665                 670         


Asp Leu Glu Arg Asn Asn Gly Ser Leu Asp Arg Pro Tyr Tyr Met Ser 
        675                 680                 685             


Lys Ser Leu Leu Lys Ile Leu Gly Lys Lys Asn Glu Ala Pro Pro Asp 
    690                 695                 700                 


Asn Lys Lys Arg Lys Lys 
705                 710 


<210>  5143
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  5143

Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Thr Pro Thr Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Thr Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Thr Val Leu His Val Leu Gly Asp Arg Thr Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Thr His Gly Ser Val Tyr Pro Gln Leu Leu 
    130                 135                 140                 


Ile Pro Leu Leu Gly Ala Gly Leu Val Leu Gly Leu Gly Ala Leu Gly 
145                 150                 155                 160 


Leu Val Trp Trp Leu His Arg Arg Leu Pro Pro Gln Pro Ile Arg Pro 
                165                 170                 175     


Leu Pro Arg Phe Ala Leu Ser Pro Pro His Ser Ser Thr Cys Glu Asn 
            180                 185                 190         


Arg Ala Pro Glu Ala Ser Lys Gly Gly Arg Ala Gln Asp Ser Arg Gly 
        195                 200                 205             


Pro Gly Pro Gly Thr Glu Pro Ala Leu Cys Gly Ser Gly Pro Ser Ser 
    210                 215                 220                 


Pro Gln Gln Ala Pro Pro Ala Val His Ser Gly Pro Cys 
225                 230                 235         


<210>  5144
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  5144

Met Lys Ala Leu Met Leu Leu Thr Leu Ser Val Leu Leu Cys Trp Val 
1               5                   10                  15      


Ser Ala Asp Ile Arg Cys His Ser Cys Tyr Lys Val Pro Val Leu Gly 
            20                  25                  30          


Cys Val Asp Arg Gln Ser Cys Arg Leu Glu Pro Gly Gln Gln Cys Leu 
        35                  40                  45              


Thr Thr His Ala Tyr Leu Gly Lys Met Trp Val Phe Ser Asn Leu Arg 
    50                  55                  60                  


Cys Gly Thr Pro Glu Glu Pro Cys Gln Glu Ala Phe Asn Gln Thr Asn 
65                  70                  75                  80  


Arg Lys Leu Gly Leu Thr Tyr Asn Thr Thr Cys Cys Asn Lys Asp Asn 
                85                  90                  95      


Cys Asn Ser Ala Gly Pro Arg Pro Thr Pro Ala Leu Gly Leu Val Phe 
            100                 105                 110         


Leu Thr Ser Leu Ala Gly Leu Gly Leu Trp Leu Leu His 
        115                 120                 125 


<210>  5145
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  5145

Met Arg Phe Met Ala Gly Pro Ala Gly Ser Gln Ser Leu Gly Pro Leu 
1               5                   10                  15      


Cys Phe His Ser Ser Pro Gln Ala Leu Tyr Thr Val Leu Leu Ile Val 
            20                  25                  30          


Leu Val Met Met Ser Leu Val Phe Gly Lys Phe Val Pro Val Asn Trp 
        35                  40                  45              


Glu Pro Pro Gln Pro Leu Pro Phe Pro Lys Tyr Leu Arg Cys Tyr Arg 
    50                  55                  60                  


Cys Leu Leu Glu Thr Lys Glu Leu Gly Cys Leu Leu Gly Ser Asp Ile 
65                  70                  75                  80  


Cys Leu Thr Pro Ala Gly Ser Ser Cys Ile Thr Leu His Lys Lys Asn 
                85                  90                  95      


Ser Ser Gly Ser Asp Val Met Val Ser Asp Cys Arg Ser Lys Glu Gln 
            100                 105                 110         


Met Ser Asp Cys Ser Asn Thr Arg Thr Ser Pro Val Ser Gly Phe Trp 
        115                 120                 125             


Ile Phe Ser Gln Tyr Cys Phe Leu Asp Phe Cys Asn Asp Pro Gln Asn 
    130                 135                 140                 


Arg Gly Leu Tyr Thr Pro 
145                 150 


<210>  5146
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  5146

Met Val Leu Pro Pro Pro Asp Arg Arg His Val Cys Leu Thr Thr Leu 
1               5                   10                  15      


Val Ile Met Gly Ser Met Ala Val Met Asp Ala Tyr Leu Val Glu Gln 
            20                  25                  30          


Asn Gln Gly Pro Arg Lys Ile Gly Val Cys Ile Ile Val Leu Val Gly 
        35                  40                  45              


Asp Val Cys Phe Leu Leu Val Leu Arg Tyr Val Ala Val Trp Val Gly 
    50                  55                  60                  


Ala Glu Val Arg Thr Ala Lys Arg Gly Tyr Ala Met Ile Leu Trp Phe 
65                  70                  75                  80  


Leu Tyr Ile Phe Val Leu Glu Ile Lys Leu Tyr Phe Ile Phe Gln Asn 
                85                  90                  95      


Tyr Lys Ala Ala Arg Arg Gly Ala Ala Asp Pro Val Ala Arg Lys Ala 
            100                 105                 110         


Leu Thr Leu Leu Leu Ser Val Cys Val Pro Gly Leu Phe Leu Leu Leu 
        115                 120                 125             


Val Ala Leu Asp Arg Met Glu Tyr Val Arg Thr Phe Arg Lys Arg Glu 
    130                 135                 140                 


Asp Leu Arg Gly Arg Leu Phe Trp Val Ala Leu Asp Leu Leu Asp Leu 
145                 150                 155                 160 


Leu Asp Met Gln Ala Ser Leu Trp Glu Pro Pro Arg Ser Gly Leu Pro 
                165                 170                 175     


Leu Trp Ala Glu Gly Leu Thr Phe Phe Tyr Cys Tyr Met Leu Leu Leu 
            180                 185                 190         


Val Leu Pro Cys Val Ala Leu Ser Glu Val Ser Met Gln Gly Glu His 
        195                 200                 205             


Ile Ala Pro Gln Lys Met Met Leu Tyr Pro Val Leu Ser Leu Ala Thr 
    210                 215                 220                 


Val Asn Val Val Ala Val Leu Ala Arg Ala Ala Asn Met Ala Leu Phe 
225                 230                 235                 240 


Arg Asp Ser Arg Val Ser Ala Ile Phe Val Gly Lys Asn Val Val Ala 
                245                 250                 255     


Leu Ala Thr Lys Ala Cys Thr Phe Leu Glu Tyr Arg Arg Gln Val Arg 
            260                 265                 270         


Asp Phe Pro Pro Pro Ala Leu Ser Leu Glu Leu Gln Pro Pro Pro Pro 
        275                 280                 285             


Gln Arg Asn Ser Val Pro Pro Pro Pro Pro Pro Leu His Gly Pro Pro 
    290                 295                 300                 


Gly Arg Pro His Met Ser Ser Pro Thr Arg Asp Pro Leu Asp Thr 
305                 310                 315                 


<210>  5147
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  5147

Met Val Met Ser Gln Gly Thr Tyr Thr Phe Leu Thr Cys Phe Ala Gly 
1               5                   10                  15      


Phe Trp Leu Ile Trp Gly Leu Ile Val Leu Leu Cys Cys Phe Cys Ser 
            20                  25                  30          


Phe Leu Arg Arg Arg Leu Lys Arg Arg Gln Glu Glu Arg Leu Arg Glu 
        35                  40                  45              


Gln Asn Leu Arg Ala Leu Glu Leu Glu Pro Leu Glu Leu Glu Gly Ser 
    50                  55                  60                  


Leu Ala Gly Ser Pro Pro Gly Leu Ala Pro Pro Gln Pro Pro Pro His 
65                  70                  75                  80  


Arg Ser Arg Leu Glu Ala Pro Ala His Ala His Ser His Pro His Val 
                85                  90                  95      


His Val His Pro Leu Leu His His Gly Pro Ala Gln Pro His Ala His 
            100                 105                 110         


Ala His Pro His Pro His His His Ala Leu Pro His Pro Pro Pro Thr 
        115                 120                 125             


His Leu Ser Val Pro Pro Arg Pro Trp Ser Tyr Pro Arg Gln Ala Glu 
    130                 135                 140                 


Ser Asp Met Ser Lys Pro Pro Cys Tyr Glu Glu Ala Val Leu Met Ala 
145                 150                 155                 160 


Glu Pro Pro Pro Pro Tyr Ser Glu Val Leu Thr Asp Thr Arg Gly Leu 
                165                 170                 175     


Tyr Arg Lys Ile Val Thr Pro Phe Leu Ser Arg Arg Asp Ser Ala Glu 
            180                 185                 190         


Lys Gln Glu Gln Pro Pro Pro Ser Tyr Lys Pro Leu Phe Leu Asp Arg 
        195                 200                 205             


Gly Tyr Thr Ser Ala Leu His Leu Pro Ser Ala Pro Arg Pro Ala Pro 
    210                 215                 220                 


Pro Cys Pro Ala Leu Cys Leu Gln Ala Asp Arg Gly Arg Arg Val Phe 
225                 230                 235                 240 


Pro Ser Trp Thr Asp Ser Glu Leu Ser Ser Arg Glu Pro Leu Glu His 
                245                 250                 255     


Gly Ala Trp Arg Leu Pro Val Ser Ile Pro Leu Phe Gly Arg Thr Thr 
            260                 265                 270         


Ala Val 
        


<210>  5148
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  5148

Met Gly Leu Pro Trp Gly Gln Pro His Leu Gly Leu Gln Met Leu Leu 
1               5                   10                  15      


Leu Ala Leu Asn Cys Leu Arg Pro Ser Leu Ser Leu Gly Glu Trp Gly 
            20                  25                  30          


Ser Trp Met Asp Ala Ser Ser Gln Thr Gln Gly Ala Gly Gly Pro Ala 
        35                  40                  45              


Gly Val Ile Gly Pro Trp Ala Pro Ala Pro Leu Arg Leu Gly Glu Ala 
    50                  55                  60                  


Ala Pro Gly Thr Pro Thr Pro Val Ser Val Ala His Leu Leu Ser Pro 
65                  70                  75                  80  


Val Ala Thr Glu Leu Val Pro Tyr Thr Pro Gln Ile Thr Ala Trp Asp 
                85                  90                  95      


Leu Glu Gly Lys Val Thr Ala Thr Thr Phe Ser Leu Glu Gln Pro Arg 
            100                 105                 110         


Cys Val Phe Asp Gly Leu Ala Ser Ala Ser Asp Thr Val Trp Leu Val 
        115                 120                 125             


Val Ala Phe Ser Asn Ala Ser Arg Gly Phe Gln Asn Pro Glu Thr Leu 
    130                 135                 140                 


Ala Asp Ile Pro Ala Ser Pro Gln Leu Leu Thr Asp Gly His Tyr Met 
145                 150                 155                 160 


Thr Leu Pro Leu Ser Pro Asp Gln Leu Pro Cys Gly Asp Pro Met Ala 
                165                 170                 175     


Gly Ser Gly Gly Ala Pro Val Leu Arg Val Gly His Asp His Gly Cys 
            180                 185                 190         


His Gln Gln Pro Phe Cys Asn Ala Pro Leu Pro Gly Pro Gly Pro Tyr 
        195                 200                 205             


Arg Glu Asp Pro Arg Ile His Arg His Leu Ala Arg Ala Ala Lys Trp 
    210                 215                 220                 


Gln His Asp Arg His Tyr Leu His Pro Leu Phe Ser Gly Arg Pro Pro 
225                 230                 235                 240 


Thr Leu Gly Leu Leu Gly Ser Leu Tyr His Ala Leu Leu Gln Pro Val 
                245                 250                 255     


Val Ala Gly Gly Gly Pro Gly Ala Ala Ala Asp Arg Leu Leu His Gly 
            260                 265                 270         


Gln Ala Leu His Asp Pro Pro His Pro Thr Gln Arg Gly Arg His Thr 
        275                 280                 285             


Ala Gly Gly Leu Gln Ala Trp Pro Gly Pro Pro Pro Gln Pro Gln Pro 
    290                 295                 300                 


Leu Ala Trp Pro Leu Cys Met Gly Leu Gly Glu Met Gly Arg Arg Glu 
305                 310                 315                 320 


<210>  5149
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  5149

Met Lys Gly Leu Arg Ser Leu Ala Ala Thr Thr Leu Ala Leu Phe Leu 
1               5                   10                  15      


Val Phe Val Phe Leu Gly Asn Ser Ser Cys Ala Pro Gln Arg Leu Leu 
            20                  25                  30          


Glu Arg Arg Asn Trp Thr Pro Gln Ala Met Leu Tyr Leu Lys Gly Ala 
        35                  40                  45              


Gln Gly Arg Arg Phe Ile Ser Asp Gln Ser Arg Arg Lys Asp Leu Ser 
    50                  55                  60                  


Asp Arg Pro Leu Pro Glu Arg Arg Ser Pro Asn Pro Gln Leu Leu Thr 
65                  70                  75                  80  


Ile Pro Glu Ala Ala Thr Ile Leu Leu Ala Ser Leu Gln Lys Ser Pro 
                85                  90                  95      


Glu Asp Glu Glu Lys Asn Phe Asp Gln Thr Arg Phe Leu Glu Asp Ser 
            100                 105                 110         


Leu Leu Asn Trp 
        115     


<210>  5150
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  5150

Met Ser Gly Ser Met Ala Thr Ala Glu Ala Ser Gly Ser Asp Gly Lys 
1               5                   10                  15      


Gly Gln Glu Val Glu Thr Ser Val Thr Tyr Tyr Arg Leu Glu Glu Val 
            20                  25                  30          


Ala Lys Arg Asn Ser Leu Lys Glu Leu Trp Leu Val Ile His Gly Arg 
        35                  40                  45              


Val Tyr Asp Val Thr Arg Phe Leu Asn Glu His Pro Gly Gly Glu Glu 
    50                  55                  60                  


Val Leu Leu Glu Gln Ala Gly Val Asp Ala Ser Glu Ser Phe Glu Asp 
65                  70                  75                  80  


Val Gly His Ser Ser Asp Ala Arg Glu Met Leu Lys Gln Tyr Tyr Ile 
                85                  90                  95      


Gly Asp Ile His Pro Ser Asp Leu Lys Pro Glu Ser Gly Ser Lys Asp 
            100                 105                 110         


Pro Ser Lys Asn Asp Thr Cys Lys Ser Cys Trp Ala Tyr Trp Ile Leu 
        115                 120                 125             


Pro Ile Ile Gly Ala Val Leu Leu Gly Phe Leu Tyr Arg Tyr Tyr Thr 
    130                 135                 140                 


Ser Glu Ser Lys Ser Ser 
145                 150 


<210>  5151
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  5151

Met Leu Ala Ser Gly Leu Leu Leu Val Ala Leu Leu Ala Cys Leu Thr 
1               5                   10                  15      


Val Met Val Leu Met Ser Val Trp Gln Gln Arg Lys Ser Arg Gly Lys 
            20                  25                  30          


Leu Pro Pro Gly Pro Thr Pro Leu Pro Phe Ile Gly Asn Tyr Leu Gln 
        35                  40                  45              


Leu Asn Thr Glu His Ile Cys Asp Ser Ile Met Lys Val Ser Gln Gly 
    50                  55                  60                  


Val Ala Phe Ser Asn Gly Glu Arg Ala Lys Gln Leu Leu Arg Phe Ala 
65                  70                  75                  80  


Ile Ala Thr Leu Arg Asp Phe Gly Val Gly Lys Arg Gly Ile Glu Glu 
                85                  90                  95      


Arg Ile Gln Glu Glu Ser Gly Phe Leu Ile Glu Ala Ile Arg Ser Thr 
            100                 105                 110         


His Gly Ala Asn Ile Asp Pro Thr Phe Phe Leu Ser Arg Thr Val Ser 
        115                 120                 125             


Asn Val Ile Ser Ser Ile Val Phe Gly Asp Arg Phe Asp Tyr Glu Asp 
    130                 135                 140                 


Lys Glu Phe Leu Ser Leu Leu Ser Met Met Leu Gly Ile Phe Gln Phe 
145                 150                 155                 160 


Thr Ser Thr Ser Thr Gly Gln Leu Tyr Glu Met Phe Ser Ser Val Met 
                165                 170                 175     


Lys His Leu Pro Gly Pro Gln Gln Gln Ala Phe Lys Leu Leu Gln Gly 
            180                 185                 190         


Leu Glu Asp Phe Ile Ala Lys Lys Val Glu His Asn Gln Arg Thr Leu 
        195                 200                 205             


Asp Pro Asn Ser Pro Gln Asp Phe Ile Asp Ser Phe Leu Ile His Met 
    210                 215                 220                 


Gln Glu Glu Glu Lys Asn Pro Asn Thr Glu Phe Tyr Leu Lys Asn Leu 
225                 230                 235                 240 


Met Met Ser Thr Leu Asn Leu Phe Ile Ala Gly Thr Glu Thr Val Ser 
                245                 250                 255     


Thr Thr Leu Arg Tyr Gly Phe Leu Leu Leu Met Lys His Pro Glu Val 
            260                 265                 270         


Glu Ala Lys Val His Glu Glu Ile Asp Arg Val Ile Gly Lys Asn Arg 
        275                 280                 285             


Gln Pro Lys Phe Glu Asp Arg Thr Lys Met Pro Tyr Met Glu Ala Val 
    290                 295                 300                 


Ile His Glu Ile Gln Arg Phe Gly Asp Val Ile Pro Met Ser Leu Ala 
305                 310                 315                 320 


Arg Arg Val Lys Lys Asp Thr Lys Phe Arg Asp Phe Phe Leu Pro Lys 
                325                 330                 335     


Gly Thr Glu Val Phe Pro Met Leu Gly Ser Val Leu Arg Asp Pro Ser 
            340                 345                 350         


Phe Phe Ser Asn Pro Gln Asp Phe Asn Pro Gln His Phe Leu Asp Asp 
        355                 360                 365             


Lys Gly Gln Phe Lys Lys Ser Asp Ala Phe Val Pro Phe Ser Ile Gly 
    370                 375                 380                 


Lys Arg Asn Cys Phe Gly Glu Gly Leu Ala Arg Met Glu Leu Phe Leu 
385                 390                 395                 400 


Phe Phe Thr Thr Val Met Gln Asn Phe Arg Leu Lys Ser Ser Gln Ser 
                405                 410                 415     


Pro Lys Asp Ile Asp Val Ser Pro Lys His Val Val Phe Ala Thr Ile 
            420                 425                 430         


Pro Arg Asn Tyr Thr Met Ser Phe Leu Pro Arg 
        435                 440             


<210>  5152
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  5152

Met Glu Ala Thr Gly Thr Trp Ala Leu Leu Leu Ala Leu Ala Leu Leu 
1               5                   10                  15      


Leu Leu Leu Thr Leu Ala Leu Ser Gly Thr Arg Ala Arg Gly His Leu 
            20                  25                  30          


Pro Pro Gly Pro Thr Pro Leu Pro Leu Leu Gly Asn Leu Leu Gln Leu 
        35                  40                  45              


Arg Pro Gly Ala Leu Tyr Ser Gly Leu Met Arg Leu Ser Lys Lys Tyr 
    50                  55                  60                  


Gly Pro Val Phe Thr Ile Tyr Leu Gly Pro Trp Arg Pro Val Val Val 
65                  70                  75                  80  


Leu Val Gly Gln Glu Ala Val Arg Glu Ala Leu Gly Gly Gln Ala Glu 
                85                  90                  95      


Glu Phe Ser Gly Arg Gly Thr Val Ala Met Leu Glu Gly Thr Phe Asp 
            100                 105                 110         


Gly His Gly Val Phe Phe Ser Asn Gly Glu Arg Trp Arg Gln Leu Arg 
        115                 120                 125             


Lys Phe Thr Met Leu Ala Leu Arg Asp Leu Gly Met Gly Lys Arg Glu 
    130                 135                 140                 


Gly Glu Glu Leu Ile Gln Ala Glu Ala Arg Cys Leu Val Glu Thr Phe 
145                 150                 155                 160 


Gln Gly Thr Glu Gly Arg Pro Phe Asp Pro Ser Leu Leu Leu Ala Gln 
                165                 170                 175     


Ala Thr Ser Asn Val Val Cys Ser Leu Leu Phe Gly Leu Arg Phe Ser 
            180                 185                 190         


Tyr Glu Asp Lys Glu Phe Gln Ala Val Val Arg Ala Ala Gly Gly Thr 
        195                 200                 205             


Leu Leu Gly Val Ser Ser Gln Gly Gly Gln Thr Tyr Glu Met Phe Ser 
    210                 215                 220                 


Trp Phe Leu Arg Pro Leu Pro Gly Pro His Lys Gln Leu Leu His His 
225                 230                 235                 240 


Val Ser Thr Leu Ala Ala Phe Thr Val Arg Gln Val Gln Gln His Gln 
                245                 250                 255     


Gly Asn Leu Asp Ala Ser Gly Pro Ala Arg Asp Leu Val Asp Ala Phe 
            260                 265                 270         


Leu Leu Lys Met Ala Gln Glu Glu Gln Asn Pro Gly Thr Glu Phe Thr 
        275                 280                 285             


Asn Lys Asn Met Leu Met Thr Val Ile Tyr Leu Leu Phe Ala Gly Thr 
    290                 295                 300                 


Met Thr Val Ser Thr Thr Val Gly Tyr Thr Leu Leu Leu Leu Met Lys 
305                 310                 315                 320 


Tyr Pro His Val Gln Lys Trp Val Arg Glu Glu Leu Asn Arg Glu Leu 
                325                 330                 335     


Gly Ala Gly Gln Ala Pro Ser Leu Gly Asp Arg Thr Arg Leu Pro Tyr 
            340                 345                 350         


Thr Asp Ala Val Leu His Glu Ala Gln Arg Leu Leu Ala Leu Val Pro 
        355                 360                 365             


Met Gly Ile Pro Arg Thr Leu Met Arg Thr Thr Arg Phe Arg Gly Tyr 
    370                 375                 380                 


Thr Leu Pro Gln Gly Thr Glu Val Phe Pro Leu Leu Gly Ser Ile Leu 
385                 390                 395                 400 


His Asp Pro Asn Ile Phe Lys His Pro Glu Glu Phe Asn Pro Asp Arg 
                405                 410                 415     


Phe Leu Asp Ala Asp Gly Arg Phe Arg Lys His Glu Ala Phe Leu Pro 
            420                 425                 430         


Phe Ser Leu Gly Lys Arg Val Cys Leu Gly Glu Gly Leu Ala Lys Ala 
        435                 440                 445             


Glu Leu Phe Leu Phe Phe Thr Thr Ile Leu Gln Ala Phe Ser Leu Glu 
    450                 455                 460                 


Ser Pro Cys Pro Pro Asp Thr Leu Ser Leu Lys Pro Thr Val Ser Gly 
465                 470                 475                 480 


Leu Phe Asn Ile Pro Pro Ala Phe Gln Leu Gln Val Arg Pro Thr Asp 
                485                 490                 495     


Leu His Ser Thr Thr Gln Thr Arg 
            500                 


<210>  5153
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  5153

Met Gly Ser Trp Val Gln Leu Ile Thr Ser Val Gly Val Gln Gln Asn 
1               5                   10                  15      


His Pro Gly Trp Thr Val Ala Gly Gln Phe Gln Glu Lys Lys Arg Phe 
            20                  25                  30          


Thr Glu Glu Val Ile Glu Tyr Phe Gln Lys Lys Val Ser Pro Val His 
        35                  40                  45              


Leu Lys Ile Leu Leu Thr Ser Asp Glu Ala Trp Lys Arg Phe Val Arg 
    50                  55                  60                  


Val Ala Glu Leu Pro Arg Glu Glu Ala Asp Ala Leu Tyr Glu Ala Leu 
65                  70                  75                  80  


Lys Asn Leu Thr Pro Tyr Val Ala Ile Glu Asp Lys Asp Met Gln Gln 
                85                  90                  95      


Lys Glu Gln Gln Phe Arg Glu Trp Phe Leu Lys Glu Phe Pro Gln Ile 
            100                 105                 110         


Arg Trp Lys Ile Gln Glu Ser Ile Glu Arg Leu Arg Val Ile Ala Asn 
        115                 120                 125             


Glu Ile Glu Lys Val His Arg Gly Cys Val Ile Ala Asn Val Val Ser 
    130                 135                 140                 


Gly Ser Thr Gly Ile Leu Ser Val Ile Gly Val Met Leu Ala Pro Phe 
145                 150                 155                 160 


Thr Ala Gly Leu Ser Leu Ser Ile Thr Ala Ala Gly Val Gly Leu Gly 
                165                 170                 175     


Ile Ala Ser Ala Thr Ala Gly Ile Ala Ser Ser Ile Val Glu Asn Thr 
            180                 185                 190         


Tyr Thr Arg Ser Ala Glu Leu Thr Ala Ser Arg Leu Thr Ala Thr Ser 
        195                 200                 205             


Thr Asp Gln Leu Glu Ala Leu Arg Asp Ile Leu Arg Asp Ile Thr Pro 
    210                 215                 220                 


Asn Val Leu Ser Phe Ala Leu Asp Phe Asp Glu Ala Thr Lys Met Ile 
225                 230                 235                 240 


Ala Asn Asp Val His Thr Leu Arg Arg Ser Lys Ala Thr Val Gly Arg 
                245                 250                 255     


Pro Leu Ile Ala Trp Arg Tyr Val Pro Ile Asn Val Val Glu Thr Leu 
            260                 265                 270         


Arg Thr Arg Gly Ala Pro Thr Arg Ile Val Arg Lys Val Ala Arg Asn 
        275                 280                 285             


Leu Gly Lys Ala Thr Ser Gly Val Leu Val Val Leu Asp Val Val Asn 
    290                 295                 300                 


Leu Val Gln Asp Ser Leu Asp Leu His Lys Gly Ala Lys Ser Glu Ser 
305                 310                 315                 320 


Ala Glu Ser Leu Arg Gln Trp Ala Gln Glu Leu Glu Glu Asn Leu Asn 
                325                 330                 335     


Glu Leu Thr His Ile His Gln Ser Leu Lys Ala Gly 
            340                 345             


<210>  5154
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  5154

Met Gly Gly Leu Phe Ser Arg Trp Arg Thr Lys Pro Ser Thr Val Glu 
1               5                   10                  15      


Val Leu Glu Ser Ile Asp Lys Glu Ile Gln Ala Leu Glu Glu Phe Arg 
            20                  25                  30          


Glu Lys Asn Gln Arg Leu Gln Lys Leu Trp Val Gly Arg Leu Ile Leu 
        35                  40                  45              


Tyr Ser Ser Val Leu Tyr Leu Phe Thr Cys Leu Ile Val Tyr Leu Trp 
    50                  55                  60                  


Tyr Leu Pro Asp Glu Phe Thr Ala Arg Leu Ala Met Thr Leu Pro Phe 
65                  70                  75                  80  


Phe Ala Phe Pro Leu Ile Ile Trp Ser Ile Arg Thr Val Ile Ile Phe 
                85                  90                  95      


Phe Phe Ser Lys Arg Thr Glu Arg Asn Asn Glu Ala Leu Asp Asp Leu 
            100                 105                 110         


Lys Ser Gln Arg Lys Lys Ile Leu Glu Glu Val Met Glu Lys Glu Thr 
        115                 120                 125             


Tyr Lys Thr Ala Lys Leu Ile Leu Glu Arg Phe Asp Pro Asp Ser Lys 
    130                 135                 140                 


Lys Ala Lys Glu Cys Glu Pro Pro Ser Ala Gly Ala Ala Val Thr Ala 
145                 150                 155                 160 


Arg Pro Gly Gln Glu Ile Arg Gln Arg Thr Ala Ala Gln Arg Asn Leu 
                165                 170                 175     


Ser Pro Thr Pro Ala Ser Pro Asn Gln Gly Pro Pro Pro Gln Val Pro 
            180                 185                 190         


Val Ser Pro Gly Pro Pro Lys Asp Ser Ser Ala Pro Gly Gly Pro Pro 
        195                 200                 205             


Glu Arg Thr Val Thr Pro Ala Leu Ser Ser Asn Val Leu Pro Arg His 
    210                 215                 220                 


Leu Gly Ser Pro Ala Thr Ser Val Pro Gly Met Gly Leu His Pro Pro 
225                 230                 235                 240 


Gly Pro Pro Leu Ala Arg Pro Ile Leu Pro Arg Glu Arg Gly Ala Leu 
                245                 250                 255     


Asp Arg Ile Val Glu Tyr Leu Val Gly Asp Gly Pro Gln Asn Arg Tyr 
            260                 265                 270         


Ala Leu Ile Cys Gln Gln Cys Phe Ser His Asn Gly Met Ala Leu Lys 
        275                 280                 285             


Glu Glu Phe Glu Tyr Ile Ala Phe Arg Cys Ala Tyr Cys Phe Phe Leu 
    290                 295                 300                 


Asn Pro Ala Arg Lys Thr Arg Pro Gln Ala Pro Arg Leu Pro Glu Phe 
305                 310                 315                 320 


Ser Phe Glu Lys Arg Gln Val Val Glu Gly Ser Ser Ser Val Gly Pro 
                325                 330                 335     


Leu Pro Ser Gly Ser Val Leu Ser Ser Asp Asn Gln Phe Asn Glu Glu 
            340                 345                 350         


Ser Leu Glu His Asp Val Leu Asp Asp Asn Thr Glu Gln Thr Asp Asp 
        355                 360                 365             


Lys Ile Pro Ala Thr Glu Gln Thr Asn Gln Val Ile Glu Lys Ala Ser 
    370                 375                 380                 


Asp Ser Glu Glu Pro Glu Glu Lys Gln Glu Thr Glu Asn Glu Glu Ala 
385                 390                 395                 400 


Ser Val Ile Glu Thr Asn Ser Thr Val Pro Gly Ala Asp Ser Ile Pro 
                405                 410                 415     


Asp Pro Glu Leu Ser Gly Glu Ser Leu Thr Ala Glu 
            420                 425             


<210>  5155
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  5155

Met Ser Ser Glu Lys Ser Gly Leu Pro Asp Ser Val Pro His Thr Ser 
1               5                   10                  15      


Pro Pro Pro Tyr Asn Ala Pro Gln Pro Pro Ala Glu Pro Pro Ala Pro 
            20                  25                  30          


Pro Pro Gln Ala Ala Pro Ser Ser His His His His His His His Tyr 
        35                  40                  45              


His Gln Ser Gly Thr Ala Thr Leu Pro Arg Leu Gly Ala Gly Gly Leu 
    50                  55                  60                  


Ala Ser Ser Ala Ala Thr Ala Gln Arg Gly Pro Ser Ser Ser Ala Thr 
65                  70                  75                  80  


Leu Pro Arg Pro Pro His His Ala Pro Pro Gly Pro Ala Ala Gly Ala 
                85                  90                  95      


Pro Pro Pro Gly Cys Ala Thr Leu Pro Arg Met Pro Pro Asp Pro Tyr 
            100                 105                 110         


Leu Gln Glu Thr Arg Phe Glu Gly Pro Leu Pro Pro Pro Pro Pro Ala 
        115                 120                 125             


Ala Ala Ala Pro Pro Pro Pro Ala Pro Ala Gln Thr Ala Gln Ala Pro 
    130                 135                 140                 


Gly Phe Val Val Pro Thr His Ala Gly Thr Val Gly Thr Leu Pro Leu 
145                 150                 155                 160 


Gly Gly Tyr Val Ala Pro Gly Tyr Pro Leu Gln Leu Gln Pro Cys Thr 
                165                 170                 175     


Ala Tyr Val Pro Val Tyr Pro Val Gly Thr Pro Tyr Ala Gly Gly Thr 
            180                 185                 190         


Pro Gly Gly Thr Gly Val Thr Ser Thr Leu Pro Pro Pro Pro Gln Gly 
        195                 200                 205             


Pro Gly Leu Ala Leu Leu Glu Pro Arg Arg Pro Pro His Asp Tyr Met 
    210                 215                 220                 


Pro Ile Ala Val Leu Thr Thr Ile Cys Cys Phe Trp Pro Thr Gly Ile 
225                 230                 235                 240 


Ile Ala Ile Phe Lys Ala Val Gln Val Arg Thr Ala Leu Ala Arg Gly 
                245                 250                 255     


Asp Met Val Ser Ala Glu Ile Ala Ser Arg Glu Ala Arg Asn Phe Ser 
            260                 265                 270         


Phe Ile Ser Leu Ala Val Gly Ile Ala Ala Met Val Leu Cys Thr Ile 
        275                 280                 285             


Leu Thr Val Val Ile Ile Ile Ala Ala Gln His His Glu Asn Tyr Trp 
    290                 295                 300                 


Asp Pro 
305     


<210>  5156
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  5156

Met Tyr Ser Phe Met Gly Gly Gly Leu Phe Cys Ala Trp Val Gly Thr 
1               5                   10                  15      


Ile Leu Leu Val Val Ala Met Ala Thr Asp His Trp Met Gln Tyr Arg 
            20                  25                  30          


Leu Ser Gly Ser Phe Ala His Gln Gly Leu Trp Arg Tyr Cys Leu Gly 
        35                  40                  45              


Asn Lys Cys Tyr Leu Gln Thr Asp Ser Ile Gly Glu Pro Pro Gly Gln 
    50                  55                  60                  


Gly Pro Gly Arg Ala Trp Gly Lys Ser Arg Ala Asp Leu Gly Ala Gln 
65                  70                  75                  80  


Gly His Leu Tyr Ser Arg Trp Arg Thr Leu Arg Leu Lys Glu Gly Lys 
                85                  90                  95      


Gly Ala Thr Gln Ala Tyr Trp Asn Ala Thr Arg Ala Phe Met Ile Leu 
            100                 105                 110         


Ser Ala Leu Cys Ala Ile Ser Gly Ile Ile Met Gly Ile Met Ala Phe 
        115                 120                 125             


Ala His Gln Pro Thr Phe Ser Arg Ile Ser Arg Pro Phe Ser Ala Gly 
    130                 135                 140                 


Ile Met Phe Phe Ser Ser Thr Leu Phe Val Val Leu Ala Leu Ala Ile 
145                 150                 155                 160 


Tyr Thr Gly Val Thr Val Ser Phe Leu Gly Arg Arg Phe Gly Asp Trp 
                165                 170                 175     


Arg Phe Ser Trp Ser Tyr Ile Leu Gly Trp Val Ala Val Leu Met Thr 
            180                 185                 190         


Phe Phe Ala Gly Ile Phe Tyr Met Cys Ala Tyr Arg Val His Glu Cys 
        195                 200                 205             


Arg Arg Leu Ser Thr Pro Arg 
    210                 215 


<210>  5157
<211>  1216
<212>  PRT
<213>  Homo sapiens

<400>  5157

Met Gly His Leu Pro Thr Gly Ile His Gly Ala Arg Arg Leu Leu Pro 
1               5                   10                  15      


Leu Leu Trp Leu Phe Val Leu Phe Lys Asn Ala Thr Ala Phe His Val 
            20                  25                  30          


Thr Val Gln Asp Asp Asn Asn Ile Val Val Ser Leu Glu Ala Ser Asp 
        35                  40                  45              


Val Ile Ser Pro Ala Ser Val Tyr Val Val Lys Ile Thr Gly Glu Ser 
    50                  55                  60                  


Lys Asn Tyr Phe Phe Glu Phe Glu Glu Phe Asn Ser Thr Leu Pro Pro 
65                  70                  75                  80  


Pro Val Ile Phe Lys Ala Ser Tyr His Gly Leu Tyr Tyr Ile Ile Thr 
                85                  90                  95      


Leu Val Val Val Asn Gly Asn Val Val Thr Lys Pro Ser Arg Ser Ile 
            100                 105                 110         


Thr Val Leu Thr Lys Pro Leu Pro Val Thr Ser Val Ser Ile Tyr Asp 
        115                 120                 125             


Tyr Lys Pro Ser Pro Glu Thr Gly Val Leu Phe Glu Ile His Tyr Pro 
    130                 135                 140                 


Glu Lys Tyr Asn Val Phe Thr Arg Val Asn Ile Ser Tyr Trp Glu Gly 
145                 150                 155                 160 


Lys Asp Phe Arg Thr Met Leu Tyr Lys Asp Phe Phe Lys Gly Lys Thr 
                165                 170                 175     


Val Phe Asn His Trp Leu Pro Gly Met Cys Tyr Ser Asn Ile Thr Phe 
            180                 185                 190         


Gln Leu Val Ser Glu Ala Thr Phe Asn Lys Ser Thr Leu Val Glu Tyr 
        195                 200                 205             


Ser Gly Val Ser His Glu Pro Lys Gln His Arg Thr Ala Pro Tyr Pro 
    210                 215                 220                 


Pro Gln Asn Ile Ser Val Arg Ile Val Asn Leu Asn Lys Asn Asn Trp 
225                 230                 235                 240 


Glu Glu Gln Ser Gly Asn Phe Pro Glu Glu Ser Phe Met Arg Ser Gln 
                245                 250                 255     


Asp Thr Ile Gly Lys Glu Lys Leu Phe His Phe Thr Glu Glu Thr Pro 
            260                 265                 270         


Glu Ile Pro Ser Gly Asn Ile Ser Ser Gly Trp Pro Asp Phe Asn Ser 
        275                 280                 285             


Ser Asp Tyr Glu Thr Thr Ser Gln Pro Tyr Trp Trp Asp Ser Ala Ser 
    290                 295                 300                 


Ala Ala Pro Glu Ser Glu Asp Glu Phe Val Ser Val Leu Pro Met Glu 
305                 310                 315                 320 


Tyr Glu Asn Asn Ser Thr Leu Ser Glu Thr Glu Lys Ser Thr Ser Gly 
                325                 330                 335     


Ser Phe Ser Phe Phe Pro Val Gln Met Ile Leu Thr Trp Leu Pro Pro 
            340                 345                 350         


Lys Pro Pro Thr Ala Phe Asp Gly Phe His Ile His Ile Glu Arg Glu 
        355                 360                 365             


Glu Asn Phe Thr Glu Tyr Leu Met Val Asp Glu Glu Ala His Glu Phe 
    370                 375                 380                 


Val Ala Glu Leu Lys Glu Pro Gly Lys Tyr Lys Leu Ser Val Thr Thr 
385                 390                 395                 400 


Phe Ser Ser Ser Gly Ser Cys Glu Thr Arg Lys Ser Gln Ser Ala Lys 
                405                 410                 415     


Ser Leu Ser Phe Tyr Ile Ser Pro Ser Gly Glu Trp Ile Glu Glu Leu 
            420                 425                 430         


Thr Glu Lys Pro Gln His Val Ser Val His Val Leu Ser Ser Thr Thr 
        435                 440                 445             


Ala Leu Met Ser Trp Thr Ser Ser Gln Glu Asn Tyr Asn Ser Thr Ile 
    450                 455                 460                 


Val Ser Val Val Ser Leu Thr Cys Gln Lys Gln Lys Glu Ser Gln Arg 
465                 470                 475                 480 


Leu Glu Lys Gln Tyr Cys Thr Gln Val Asn Ser Ser Lys Pro Ile Ile 
                485                 490                 495     


Glu Asn Leu Val Pro Gly Ala Gln Tyr Gln Val Val Ile Tyr Leu Arg 
            500                 505                 510         


Lys Gly Pro Leu Ile Gly Pro Pro Ser Asp Pro Val Thr Phe Ala Ile 
        515                 520                 525             


Val Pro Thr Gly Ile Lys Asp Leu Met Leu Tyr Pro Leu Gly Pro Thr 
    530                 535                 540                 


Ala Val Val Leu Ser Trp Thr Arg Pro Tyr Leu Gly Val Phe Arg Lys 
545                 550                 555                 560 


Tyr Val Val Glu Met Phe Tyr Phe Asn Pro Ala Thr Met Thr Ser Glu 
                565                 570                 575     


Trp Thr Thr Tyr Tyr Glu Ile Ala Ala Thr Val Ser Leu Thr Ala Ser 
            580                 585                 590         


Val Arg Ile Ala Asn Leu Leu Pro Ala Trp Tyr Tyr Asn Phe Arg Val 
        595                 600                 605             


Thr Met Val Thr Trp Gly Asp Pro Glu Leu Ser Cys Cys Asp Ser Ser 
    610                 615                 620                 


Thr Ile Ser Phe Ile Thr Ala Pro Val Ala Pro Glu Ile Thr Ser Val 
625                 630                 635                 640 


Glu Tyr Phe Asn Ser Leu Leu Tyr Ile Ser Trp Thr Tyr Gly Asp Asp 
                645                 650                 655     


Thr Thr Asp Leu Ser His Ser Arg Met Leu His Trp Met Val Val Ala 
            660                 665                 670         


Glu Gly Lys Lys Lys Ile Lys Lys Ser Val Thr Arg Asn Val Met Thr 
        675                 680                 685             


Ala Ile Leu Ser Leu Pro Pro Gly Asp Ile Tyr Asn Leu Ser Val Thr 
    690                 695                 700                 


Ala Cys Thr Glu Arg Gly Ser Asn Thr Ser Met Leu Arg Leu Val Lys 
705                 710                 715                 720 


Leu Glu Pro Ala Pro Pro Lys Ser Leu Phe Ala Val Asn Lys Thr Gln 
                725                 730                 735     


Thr Ser Val Thr Leu Leu Trp Val Glu Glu Gly Val Ala Asp Phe Phe 
            740                 745                 750         


Glu Val Phe Cys Gln Gln Val Gly Ser Ser Gln Lys Thr Lys Leu Gln 
        755                 760                 765             


Glu Pro Val Ala Val Ser Ser His Val Val Thr Ile Ser Ser Leu Leu 
    770                 775                 780                 


Pro Ala Thr Ala Tyr Asn Cys Ser Val Thr Ser Phe Ser His Asp Ser 
785                 790                 795                 800 


Pro Ser Val Pro Thr Phe Ile Ala Val Ser Thr Met Val Thr Glu Met 
                805                 810                 815     


Asn Pro Asn Val Val Val Ile Ser Val Leu Ala Ile Leu Ser Thr Leu 
            820                 825                 830         


Leu Ile Gly Leu Leu Leu Val Thr Leu Ile Ile Leu Arg Lys Lys His 
        835                 840                 845             


Leu Gln Met Ala Arg Glu Cys Gly Ala Gly Thr Phe Val Asn Phe Ala 
    850                 855                 860                 


Ser Leu Glu Arg Asp Gly Lys Leu Pro Tyr Asn Trp Arg Arg Ser Ile 
865                 870                 875                 880 


Phe Ala Phe Leu Thr Leu Leu Pro Ser Cys Leu Trp Thr Asp Tyr Leu 
                885                 890                 895     


Leu Ala Phe Tyr Ile Asn Pro Trp Ser Lys Asn Gly Leu Lys Lys Arg 
            900                 905                 910         


Lys Leu Thr Asn Pro Val Gln Leu Asp Asp Phe Asp Ala Tyr Ile Lys 
        915                 920                 925             


Asp Met Ala Lys Asp Ser Asp Tyr Lys Phe Ser Leu Gln Phe Glu Glu 
    930                 935                 940                 


Leu Lys Leu Ile Gly Leu Asp Ile Pro His Phe Ala Ala Asp Leu Pro 
945                 950                 955                 960 


Leu Asn Arg Cys Lys Asn Arg Tyr Thr Asn Ile Leu Pro Tyr Asp Phe 
                965                 970                 975     


Ser Arg Val Arg Leu Val Ser Met Asn Glu Glu Glu Gly Ala Asp Tyr 
            980                 985                 990         


Ile Asn Ala Asn Tyr Ile Pro Gly  Tyr Asn Ser Pro Gln  Glu Tyr Ile 
        995                 1000                 1005             


Ala Thr  Gln Gly Pro Leu Pro  Glu Thr Arg Asn Asp  Phe Trp Lys 
    1010                 1015                 1020             


Met Val  Leu Gln Gln Lys Ser  Gln Ile Ile Val Met  Leu Thr Gln 
    1025                 1030                 1035             


Cys Asn  Glu Lys Arg Arg Val  Lys Cys Asp His Tyr  Trp Pro Phe 
    1040                 1045                 1050             


Thr Glu  Glu Pro Ile Ala Tyr  Gly Asp Ile Thr Val  Glu Met Ile 
    1055                 1060                 1065             


Ser Glu  Glu Glu Gln Asp Asp  Trp Ala Cys Arg His  Phe Arg Ile 
    1070                 1075                 1080             


Asn Tyr  Ala Asp Glu Met Gln  Asp Val Met His Phe  Asn Tyr Thr 
    1085                 1090                 1095             


Ala Trp  Pro Asp His Gly Val  Pro Thr Ala Asn Ala  Ala Glu Ser 
    1100                 1105                 1110             


Ile Leu  Gln Phe Val His Met  Val Arg Gln Gln Ala  Thr Lys Ser 
    1115                 1120                 1125             


Lys Gly  Pro Met Ile Ile His  Cys Ser Ala Gly Val  Gly Arg Thr 
    1130                 1135                 1140             


Gly Thr  Phe Ile Ala Leu Asp  Arg Leu Leu Gln His  Ile Arg Asp 
    1145                 1150                 1155             


His Glu  Phe Val Asp Ile Leu  Gly Leu Val Ser Glu  Met Arg Ser 
    1160                 1165                 1170             


Tyr Arg  Met Ser Met Val Gln  Thr Glu Glu Gln Tyr  Ile Phe Ile 
    1175                 1180                 1185             


His Gln  Cys Val Gln Leu Met  Trp Met Lys Lys Lys  Gln Gln Phe 
    1190                 1195                 1200             


Cys Ile  Ser Asp Val Ile Tyr  Glu Asn Val Ser Lys  Ser 
    1205                 1210                 1215     


<210>  5158
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  5158

Met Val Thr Glu Met Asn Pro Asn Val Val Val Ile Ser Val Leu Ala 
1               5                   10                  15      


Ile Leu Ser Thr Leu Leu Ile Gly Leu Leu Leu Val Thr Leu Ile Ile 
            20                  25                  30          


Leu Arg Lys Lys His Leu Gln Met Ala Arg Glu Cys Gly Ala Gly Thr 
        35                  40                  45              


Phe Val Asn Phe Ala Ser Leu Glu Arg Asp Gly Lys Leu Pro Tyr Asn 
    50                  55                  60                  


Trp Ser Lys Asn Gly Leu Lys Lys Arg Lys Leu Thr Asn Pro Val Gln 
65                  70                  75                  80  


Leu Asp Asp Phe Asp Ala Tyr Ile Lys Asp Met Ala Lys Asp Ser Asp 
                85                  90                  95      


Tyr Lys Phe Ser Leu Gln Phe Glu Glu Leu Lys Leu Ile Gly Leu Asp 
            100                 105                 110         


Ile Pro His Phe Ala Ala Asp Leu Pro Leu Asn Arg Cys Lys Asn Arg 
        115                 120                 125             


Tyr Thr Asn Ile Leu Pro Tyr Asp Phe Ser Arg Val Arg Leu Val Ser 
    130                 135                 140                 


Met Asn Glu Glu Glu Gly Ala Asp Tyr Ile Asn Ala Asn Tyr Ile Pro 
145                 150                 155                 160 


Gly Tyr Asn Ser Pro Gln Glu Tyr Ile Ala Thr Gln Gly Pro Leu Pro 
                165                 170                 175     


Glu Thr Arg Asn Asp Phe Trp Lys Met Val Leu Gln Gln Lys Ser Gln 
            180                 185                 190         


Ile Ile Val Met Leu Thr Gln Cys Asn Glu Lys Arg Arg Val Lys Cys 
        195                 200                 205             


Asp His Tyr Trp Pro Phe Thr Glu Glu Pro Ile Ala Tyr Gly Asp Ile 
    210                 215                 220                 


Thr Val Glu Met Ile Ser Glu Glu Glu Gln Asp Asp Trp Ala Cys Arg 
225                 230                 235                 240 


His Phe Arg Ile Asn Tyr Ala Asp Glu Met Gln Asp Val Met His Phe 
                245                 250                 255     


Asn Tyr Thr Ala Trp Pro Asp His Gly Val Pro Thr Ala Asn Ala Ala 
            260                 265                 270         


Glu Ser Ile Leu Gln Phe Val His Met Val Arg Gln Gln Ala Thr Lys 
        275                 280                 285             


Ser Lys Gly Pro Met Ile Ile His Cys Ser Ala Gly Val Gly Arg Thr 
    290                 295                 300                 


Gly Thr Phe Ile Ala Leu Asp Arg Leu Leu Gln His Ile Arg Asp His 
305                 310                 315                 320 


Glu Phe Val Asp Ile Leu Gly Leu Val Ser Glu Met Arg Ser Tyr Arg 
                325                 330                 335     


Met Ser Met Val Gln Thr Glu Glu Gln Tyr Ile Phe Ile His Gln Cys 
            340                 345                 350         


Val Gln Leu Met Trp Met Lys Lys Lys Gln Gln Phe Cys Ile Ser Asp 
        355                 360                 365             


Val Ile Tyr Glu Asn Val Ser Lys Ser 
    370                 375         


<210>  5159
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  5159

Met Val Thr Glu Met Asn Pro Asn Val Val Val Ile Ser Val Leu Ala 
1               5                   10                  15      


Ile Leu Ser Thr Leu Leu Ile Gly Leu Leu Leu Val Thr Leu Ile Ile 
            20                  25                  30          


Leu Arg Lys Lys His Leu Gln Met Ala Arg Glu Cys Gly Ala Gly Thr 
        35                  40                  45              


Phe Val Asn Phe Ala Ser Leu Glu Arg Asp Gly Lys Leu Pro Tyr Asn 
    50                  55                  60                  


Trp Arg Arg Ser Ile Phe Ala Phe Leu Thr Leu Leu Pro Ser Cys Leu 
65                  70                  75                  80  


Trp Thr Asp Tyr Leu Leu Ala Phe Tyr Ile Asn Pro Trp Ser Lys Asn 
                85                  90                  95      


Gly Leu Lys Lys Arg Lys Leu Thr Asn Pro Val Gln Leu Asp Asp Phe 
            100                 105                 110         


Asp Ala Tyr Ile Lys Asp Met Ala Lys Asp Ser Asp Tyr Lys Phe Ser 
        115                 120                 125             


Leu Gln Phe Glu Glu Leu Lys Leu Ile Gly Leu Asp Ile Pro His Phe 
    130                 135                 140                 


Ala Ala Asp Leu Pro Leu Asn Arg Cys Lys Asn Arg Tyr Thr Asn Ile 
145                 150                 155                 160 


Leu Pro Tyr Asp Phe Ser Arg Val Arg Leu Val Ser Met Asn Glu Glu 
                165                 170                 175     


Glu Gly Ala Asp Tyr Ile Asn Ala Asn Tyr Ile Pro Gly Tyr Asn Ser 
            180                 185                 190         


Pro Gln Glu Tyr Ile Ala Thr Gln Gly Pro Leu Pro Glu Thr Arg Asn 
        195                 200                 205             


Asp Phe Trp Lys Met Val Leu Gln Gln Lys Ser Gln Ile Ile Val Met 
    210                 215                 220                 


Leu Thr Gln Cys Asn Glu Lys Arg Arg Val Lys Cys Asp His Tyr Trp 
225                 230                 235                 240 


Pro Phe Thr Glu Glu Pro Ile Ala Tyr Gly Asp Ile Thr Val Glu Met 
                245                 250                 255     


Ile Ser Glu Glu Glu Gln Asp Asp Trp Ala Cys Arg His Phe Arg Ile 
            260                 265                 270         


Asn Tyr Ala Asp Glu Met Gln Asp Val Met His Phe Asn Tyr Thr Ala 
        275                 280                 285             


Trp Pro Asp His Gly Val Pro Thr Ala Asn Ala Ala Glu Ser Ile Leu 
    290                 295                 300                 


Gln Phe Val His Met Val Arg Gln Gln Ala Thr Lys Ser Lys Gly Pro 
305                 310                 315                 320 


Met Ile Ile His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Phe Ile 
                325                 330                 335     


Ala Leu Asp Arg Leu Leu Gln His Ile Arg Asp His Glu Phe Val Asp 
            340                 345                 350         


Ile Leu Gly Leu Val Ser Glu Met Arg Ser Tyr Arg Met Ser Met Val 
        355                 360                 365             


Gln Thr Glu Glu Gln Tyr Ile Phe Ile His Gln Cys Val Gln Leu Met 
    370                 375                 380                 


Trp Met Lys Lys Lys Gln Gln Phe Cys Ile Ser Asp Val Ile Tyr Glu 
385                 390                 395                 400 


Asn Val Ser Lys Ser 
                405 


<210>  5160
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  5160

Met Val Thr Glu Met Asn Pro Asn Val Val Val Ile Ser Val Leu Ala 
1               5                   10                  15      


Ile Leu Ser Thr Leu Leu Ile Gly Leu Leu Leu Val Thr Leu Ile Ile 
            20                  25                  30          


Leu Arg Lys Lys His Leu Gln Met Ala Arg Glu Cys Gly Ala Gly Thr 
        35                  40                  45              


Phe Val Asn Phe Ala Ser Leu Glu Arg Asp Gly Lys Leu Pro Tyr Asn 
    50                  55                  60                  


Trp Ser Lys Asn Gly Leu Lys Lys Arg Lys Leu Thr Asn Pro Val Gln 
65                  70                  75                  80  


Leu Asp Asp Phe Asp Ala Tyr Ile Lys Asp Met Ala Lys Asp Ser Asp 
                85                  90                  95      


Tyr Lys Phe Ser Leu Gln Phe Glu Glu Leu Lys Leu Ile Gly Leu Asp 
            100                 105                 110         


Ile Pro His Phe Ala Ala Asp Leu Pro Leu Asn Arg Cys Lys Asn Arg 
        115                 120                 125             


Tyr Thr Asn Ile Leu Pro Tyr Asp Phe Ser Arg Val Arg Leu Val Ser 
    130                 135                 140                 


Met Asn Glu Glu Glu Gly Ala Asp Tyr Ile Asn Ala Asn Tyr Ile Pro 
145                 150                 155                 160 


Gly Tyr Asn Ser Pro Gln Glu Tyr Ile Ala Thr Gln Gly Pro Leu Pro 
                165                 170                 175     


Glu Thr Arg Asn Asp Phe Trp Lys Met Val Leu Gln Gln Lys Ser Gln 
            180                 185                 190         


Ile Ile Val Met Leu Thr Gln Cys Asn Glu Lys Arg Arg Val Lys Cys 
        195                 200                 205             


Asp His Tyr Trp Pro Phe Thr Glu Glu Pro Ile Ala Tyr Gly Asp Ile 
    210                 215                 220                 


Thr Val Glu Met Ile Ser Glu Glu Glu Gln Asp Asp Trp Ala Cys Arg 
225                 230                 235                 240 


His Phe Arg Ile Asn Tyr Ala Asp Glu Met Gln Asp Val Met His Phe 
                245                 250                 255     


Asn Tyr Thr Ala Trp Pro Asp His Gly Val Pro Thr Ala Asn Ala Ala 
            260                 265                 270         


Glu Ser Ile Leu Gln Phe Val His Met Val Arg Gln Gln Ala Thr Lys 
        275                 280                 285             


Ser Lys Gly Pro Met Ile Ile His Cys Ser Ala Gly Val Gly Arg Thr 
    290                 295                 300                 


Gly Thr Phe Ile Ala Leu Asp Arg Leu Leu Gln His Ile Arg Asp His 
305                 310                 315                 320 


Glu Phe Val Asp Ile Leu Gly Leu Val Ser Glu Met Arg Ser Tyr Arg 
                325                 330                 335     


Met Ser Met Val Gln Thr Glu Glu Gln Tyr Ile Phe Ile His Gln Cys 
            340                 345                 350         


Val Gln Leu Met Trp Met Lys Lys Lys Gln Gln Phe Cys Ile Ser Asp 
        355                 360                 365             


Val Ile Tyr Glu Asn Val Ser Lys Ser 
    370                 375         


<210>  5161
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  5161

Met Val Thr Glu Met Asn Pro Asn Val Val Val Ile Ser Val Leu Ala 
1               5                   10                  15      


Ile Leu Ser Thr Leu Leu Ile Gly Leu Leu Leu Val Thr Leu Ile Ile 
            20                  25                  30          


Leu Arg Lys Lys His Leu Gln Met Ala Arg Glu Cys Gly Ala Gly Thr 
        35                  40                  45              


Phe Val Asn Phe Ala Ser Leu Glu Arg Asp Gly Lys Leu Pro Tyr Asn 
    50                  55                  60                  


Trp Arg Arg Ser Ile Phe Ala Phe Leu Thr Leu Leu Pro Ser Cys Leu 
65                  70                  75                  80  


Trp Thr Asp Tyr Leu Leu Ala Phe Tyr Ile Asn Pro Trp Ser Lys Asn 
                85                  90                  95      


Gly Leu Lys Lys Arg Lys Leu Thr Asn Pro Val Gln Leu Asp Asp Phe 
            100                 105                 110         


Asp Ala Tyr Ile Lys Asp Met Ala Lys Asp Ser Asp Tyr Lys Phe Ser 
        115                 120                 125             


Leu Gln Phe Glu Glu Leu Lys Leu Ile Gly Leu Asp Ile Pro His Phe 
    130                 135                 140                 


Ala Ala Asp Leu Pro Leu Asn Arg Cys Lys Asn Arg Tyr Thr Asn Ile 
145                 150                 155                 160 


Leu Pro Tyr Asp Phe Ser Arg Val Arg Leu Val Ser Met Asn Glu Glu 
                165                 170                 175     


Glu Gly Ala Asp Tyr Ile Asn Ala Asn Tyr Ile Pro Gly Tyr Asn Ser 
            180                 185                 190         


Pro Gln Glu Tyr Ile Ala Thr Gln Gly Pro Leu Pro Glu Thr Arg Asn 
        195                 200                 205             


Asp Phe Trp Lys Met Val Leu Gln Gln Lys Ser Gln Ile Ile Val Met 
    210                 215                 220                 


Leu Thr Gln Cys Asn Glu Lys Arg Arg Val Lys Cys Asp His Tyr Trp 
225                 230                 235                 240 


Pro Phe Thr Glu Glu Pro Ile Ala Tyr Gly Asp Ile Thr Val Glu Met 
                245                 250                 255     


Ile Ser Glu Glu Glu Gln Asp Asp Trp Ala Cys Arg His Phe Arg Ile 
            260                 265                 270         


Asn Tyr Ala Asp Glu Met Gln Asp Val Met His Phe Asn Tyr Thr Ala 
        275                 280                 285             


Trp Pro Asp His Gly Val Pro Thr Ala Asn Ala Ala Glu Ser Ile Leu 
    290                 295                 300                 


Gln Phe Val His Met Val Arg Gln Gln Ala Thr Lys Ser Lys Gly Pro 
305                 310                 315                 320 


Met Ile Ile His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Phe Ile 
                325                 330                 335     


Ala Leu Asp Arg Leu Leu Gln His Ile Arg Asp His Glu Phe Val Asp 
            340                 345                 350         


Ile Leu Gly Leu Val Ser Glu Met Arg Ser Tyr Arg Met Ser Met Val 
        355                 360                 365             


Gln Thr Glu Glu Gln Tyr Ile Phe Ile His Gln Cys Val Gln Leu Met 
    370                 375                 380                 


Trp Met Lys Lys Lys Gln Gln Phe Cys Ile Ser Asp Val Ile Tyr Glu 
385                 390                 395                 400 


Asn Val Ser Lys Ser 
                405 


<210>  5162
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  5162

Met Glu Pro His Leu Leu Gly Leu Leu Leu Gly Leu Leu Leu Gly Gly 
1               5                   10                  15      


Thr Arg Val Leu Ala Gly Tyr Pro Ile Trp Trp Ser Leu Ala Leu Gly 
            20                  25                  30          


Gln Gln Tyr Thr Ser Leu Gly Ser Gln Pro Leu Leu Cys Gly Ser Ile 
        35                  40                  45              


Pro Gly Leu Val Pro Lys Gln Leu Arg Phe Cys Arg Asn Tyr Ile Glu 
    50                  55                  60                  


Ile Met Pro Ser Val Ala Glu Gly Val Lys Leu Gly Ile Gln Glu Cys 
65                  70                  75                  80  


Gln His Gln Phe Arg Gly Arg Arg Trp Asn Cys Thr Thr Ile Asp Asp 
                85                  90                  95      


Ser Leu Ala Ile Phe Gly Pro Val Leu Asp Lys Ala Thr Arg Glu Ser 
            100                 105                 110         


Ala Phe Val His Ala Ile Ala Ser Ala Gly Val Ala Phe Ala Val Thr 
        115                 120                 125             


Arg Ser Cys Ala Glu Gly Thr Ser Thr Ile Cys Gly Cys Asp Ser His 
    130                 135                 140                 


His Lys Gly Pro Pro Gly Glu Gly Trp Lys Trp Gly Gly Cys Ser Glu 
145                 150                 155                 160 


Asp Ala Asp Phe Gly Val Leu Val Ser Arg Glu Phe Ala Asp Ala Arg 
                165                 170                 175     


Glu Asn Arg Pro Asp Ala Arg Ser Ala Met Asn Lys His Asn Asn Glu 
            180                 185                 190         


Ala Gly Arg Thr Thr Ile Leu Asp His Met His Leu Lys Cys Lys Cys 
        195                 200                 205             


His Gly Leu Ser Gly Ser Cys Glu Val Lys Thr Cys Trp Trp Ala Gln 
    210                 215                 220                 


Pro Asp Phe Arg Ala Ile Gly Asp Phe Leu Lys Asp Lys Tyr Asp Ser 
225                 230                 235                 240 


Ala Ser Glu Met Val Val Glu Lys His Arg Glu Ser Arg Gly Trp Val 
                245                 250                 255     


Glu Thr Leu Arg Ala Lys Tyr Ser Leu Phe Lys Pro Pro Thr Glu Arg 
            260                 265                 270         


Asp Leu Val Tyr Tyr Glu Asn Ser Pro Asn Phe Cys Glu Pro Asn Pro 
        275                 280                 285             


Glu Thr Gly Ser Phe Gly Thr Arg Asp Arg Thr Cys Asn Val Thr Ser 
    290                 295                 300                 


His Gly Ile Asp Gly Cys Asp Leu Leu Cys Cys Gly Arg Gly His Asn 
305                 310                 315                 320 


Thr Arg Thr Glu Lys Arg Lys Glu Lys Cys His Cys Ile Phe His Trp 
                325                 330                 335     


Cys Cys Tyr Val Ser Cys Gln Glu Cys Ile Arg Ile Tyr Asp Val His 
            340                 345                 350         


Thr Cys Lys 
        355 


<210>  5163
<211>  280
<212>  PRT
<213>  Homo sapiens

<400>  5163

Met Ala Pro Ser Gly Ser Leu Ala Val Pro Leu Ala Val Leu Val Leu 
1               5                   10                  15      


Leu Leu Trp Gly Ala Pro Trp Thr His Gly Arg Arg Ser Asn Val Arg 
            20                  25                  30          


Val Ile Thr Asp Glu Asn Trp Arg Glu Leu Leu Glu Gly Asp Trp Met 
        35                  40                  45              


Ile Glu Phe Tyr Ala Pro Trp Cys Pro Ala Cys Gln Asn Leu Gln Pro 
    50                  55                  60                  


Glu Trp Glu Ser Phe Ala Glu Trp Gly Glu Asp Leu Glu Val Asn Ile 
65                  70                  75                  80  


Ala Lys Val Asp Val Thr Glu Gln Pro Gly Leu Ser Gly Arg Phe Ile 
                85                  90                  95      


Ile Thr Ala Leu Pro Thr Ile Tyr His Cys Lys Asp Gly Glu Phe Arg 
            100                 105                 110         


Arg Tyr Gln Gly Pro Arg Thr Lys Lys Asp Phe Ile Asn Phe Ile Ser 
        115                 120                 125             


Asp Lys Glu Trp Lys Ser Ile Glu Pro Val Ser Ser Trp Phe Gly Pro 
    130                 135                 140                 


Gly Ser Val Leu Met Ser Ser Met Ser Ala Leu Phe Gln Leu Ser Met 
145                 150                 155                 160 


Trp Ile Arg Thr Cys His Asn Tyr Phe Ile Glu Asp Leu Gly Leu Pro 
                165                 170                 175     


Val Trp Gly Ser Tyr Thr Val Phe Ala Leu Ala Thr Leu Phe Ser Gly 
            180                 185                 190         


Leu Leu Leu Gly Leu Cys Met Ile Phe Val Ala Asp Cys Leu Cys Pro 
        195                 200                 205             


Ser Lys Arg Arg Arg Pro Gln Pro Tyr Pro Tyr Pro Ser Lys Lys Leu 
    210                 215                 220                 


Leu Ser Glu Ser Ala Gln Pro Leu Lys Lys Val Glu Glu Glu Gln Glu 
225                 230                 235                 240 


Ala Asp Glu Glu Asp Val Ser Glu Glu Glu Ala Glu Ser Lys Glu Gly 
                245                 250                 255     


Thr Asn Lys Asp Phe Pro Gln Asn Ala Ile Arg Gln Arg Ser Leu Gly 
            260                 265                 270         


Pro Ser Leu Ala Thr Asp Lys Ser 
        275                 280 


<210>  5164
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  5164

Met Glu Ser Gly Leu Leu Arg Pro Ala Pro Val Ser Glu Val Ile Val 
1               5                   10                  15      


Leu His Tyr Asn Tyr Thr Gly Lys Leu Arg Gly Ala Arg Tyr Gln Pro 
            20                  25                  30          


Gly Ala Gly Leu Arg Ala Asp Ala Val Val Cys Leu Ala Val Cys Ala 
        35                  40                  45              


Phe Ile Val Leu Glu Asn Leu Ala Val Leu Leu Val Leu Gly Arg His 
    50                  55                  60                  


Pro Arg Phe His Ala Pro Met Phe Leu Leu Leu Gly Ser Leu Thr Leu 
65                  70                  75                  80  


Ser Asp Leu Leu Ala Gly Ala Ala Tyr Ala Ala Asn Ile Leu Leu Ser 
                85                  90                  95      


Gly Pro Leu Thr Leu Lys Leu Ser Pro Ala Leu Trp Phe Ala Arg Glu 
            100                 105                 110         


Gly Gly Val Phe Val Ala Leu Thr Ala Ser Val Leu Ser Leu Leu Ala 
        115                 120                 125             


Ile Ala Leu Glu Arg Ser Leu Thr Met Ala Arg Arg Gly Pro Ala Pro 
    130                 135                 140                 


Val Ser Ser Arg Gly Arg Thr Leu Ala Met Ala Ala Ala Ala Trp Gly 
145                 150                 155                 160 


Val Ser Leu Leu Leu Gly Leu Leu Pro Ala Leu Gly Trp Asn Cys Leu 
                165                 170                 175     


Gly Arg Leu Asp Ala Cys Ser Thr Val Leu Pro Leu Tyr Ala Lys Ala 
            180                 185                 190         


Tyr Val Leu Phe Cys Val Leu Ala Phe Val Gly Ile Leu Ala Ala Ile 
        195                 200                 205             


Cys Ala Leu Tyr Ala Arg Ile Tyr Cys Gln Val Arg Ala Asn Ala Arg 
    210                 215                 220                 


Arg Leu Pro Ala Arg Pro Gly Thr Ala Gly Thr Thr Ser Thr Arg Ala 
225                 230                 235                 240 


Arg Arg Lys Pro Arg Ser Leu Ala Leu Leu Arg Thr Leu Ser Val Val 
                245                 250                 255     


Leu Leu Ala Phe Val Ala Cys Trp Gly Pro Leu Phe Leu Leu Leu Leu 
            260                 265                 270         


Leu Asp Val Ala Cys Pro Ala Arg Thr Cys Pro Val Leu Leu Gln Ala 
        275                 280                 285             


Asp Pro Phe Leu Gly Leu Ala Met Ala Asn Ser Leu Leu Asn Pro Ile 
    290                 295                 300                 


Ile Tyr Thr Leu Thr Asn Arg Asp Leu Arg His Ala Leu Leu Arg Leu 
305                 310                 315                 320 


Val Cys Cys Gly Arg His Ser Cys Gly Arg Asp Pro Ser Gly Ser Gln 
                325                 330                 335     


Gln Ser Ala Ser Ala Ala Glu Ala Ser Gly Gly Leu Arg Arg Cys Leu 
            340                 345                 350         


Pro Pro Gly Leu Asp Gly Ser Phe Ser Gly Ser Glu Arg Ser Ser Pro 
        355                 360                 365             


Gln Arg Asp Gly Leu Asp Thr Ser Gly Ser Thr Gly Ser Pro Gly Ala 
    370                 375                 380                 


Pro Thr Ala Ala Arg Thr Leu Val Ser Glu Pro Ala Ala Asp 
385                 390                 395             


<210>  5165
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  5165

Met Ser Pro Arg Ser Cys Leu Arg Ser Leu Arg Leu Leu Val Phe Ala 
1               5                   10                  15      


Val Phe Ser Ala Ala Ala Ser Asn Trp Leu Tyr Leu Ala Lys Leu Ser 
            20                  25                  30          


Ser Val Gly Ser Ile Ser Glu Glu Glu Thr Cys Glu Lys Leu Lys Gly 
        35                  40                  45              


Leu Ile Gln Arg Gln Val Gln Met Cys Lys Arg Asn Leu Glu Val Met 
    50                  55                  60                  


Asp Ser Val Arg Arg Gly Ala Gln Leu Ala Ile Glu Glu Cys Gln Tyr 
65                  70                  75                  80  


Gln Phe Arg Asn Arg Arg Trp Asn Cys Ser Thr Leu Asp Ser Leu Pro 
                85                  90                  95      


Val Phe Gly Lys Val Val Thr Gln Gly Thr Arg Glu Ala Ala Phe Val 
            100                 105                 110         


Tyr Ala Ile Ser Ser Ala Gly Val Ala Phe Ala Val Thr Arg Ala Cys 
        115                 120                 125             


Ser Ser Gly Glu Leu Glu Lys Cys Gly Cys Asp Arg Thr Val His Gly 
    130                 135                 140                 


Val Ser Pro Gln Gly Phe Gln Trp Ser Gly Cys Ser Asp Asn Ile Ala 
145                 150                 155                 160 


Tyr Gly Val Ala Phe Ser Gln Ser Phe Val Asp Val Arg Glu Arg Ser 
                165                 170                 175     


Lys Gly Ala Ser Ser Ser Arg Ala Leu Met Asn Leu His Asn Asn Glu 
            180                 185                 190         


Ala Gly Arg Lys Ala Ile Leu Thr His Met Arg Val Glu Cys Lys Cys 
        195                 200                 205             


His Gly Val Ser Gly Ser Cys Glu Val Lys Thr Cys Trp Arg Ala Val 
    210                 215                 220                 


Pro Pro Phe Arg Gln Val Gly His Ala Leu Lys Glu Lys Phe Asp Gly 
225                 230                 235                 240 


Ala Thr Glu Val Glu Pro Arg Arg Val Gly Ser Ser Arg Ala Leu Val 
                245                 250                 255     


Pro Arg Asn Ala Gln Phe Lys Pro His Thr Asp Glu Asp Leu Val Tyr 
            260                 265                 270         


Leu Glu Pro Ser Pro Asp Phe Cys Glu Gln Asp Met Arg Ser Gly Val 
        275                 280                 285             


Leu Gly Thr Arg Gly Arg Thr Cys Asn Lys Thr Ser Lys Ala Ile Asp 
    290                 295                 300                 


Gly Cys Glu Leu Leu Cys Cys Gly Arg Gly Phe His Thr Ala Gln Val 
305                 310                 315                 320 


Glu Leu Ala Glu Arg Cys Ser Cys Lys Phe His Trp Cys Cys Phe Val 
                325                 330                 335     


Lys Cys Arg Gln Cys Gln Arg Leu Val Glu Leu His Thr Cys Arg 
            340                 345                 350     


<210>  5166
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  5166

Met Leu Leu Trp Ser Leu Leu Val Ile Phe Asp Ala Val Thr Glu Gln 
1               5                   10                  15      


Ala Asp Ser Leu Thr Leu Val Ala Pro Ser Ser Val Phe Glu Gly Asp 
            20                  25                  30          


Ser Ile Val Leu Lys Cys Gln Gly Glu Gln Asn Trp Lys Ile Gln Lys 
        35                  40                  45              


Met Ala Tyr His Lys Asp Asn Lys Glu Leu Ser Val Phe Lys Lys Phe 
    50                  55                  60                  


Ser Asp Phe Leu Ile Gln Ser Ala Val Leu Ser Asp Ser Gly Asn Tyr 
65                  70                  75                  80  


Phe Cys Ser Thr Lys Gly Gln Leu Phe Leu Trp Asp Lys Thr Ser Asn 
                85                  90                  95      


Ile Val Lys Ile Lys Val Gln Glu Leu Phe Gln Arg Pro Val Leu Thr 
            100                 105                 110         


Ala Ser Ser Phe Gln Pro Ile Glu Gly Gly Pro Val Ser Leu Lys Cys 
        115                 120                 125             


Glu Thr Arg Leu Ser Pro Gln Arg Leu Asp Val Gln Leu Gln Phe Cys 
    130                 135                 140                 


Phe Phe Arg Glu Asn Gln Val Leu Gly Ser Gly Trp Ser Ser Ser Pro 
145                 150                 155                 160 


Glu Leu Gln Ile Ser Ala Val Trp Ser Glu Asp Thr Gly Ser Tyr Trp 
                165                 170                 175     


Cys Lys Ala Glu Thr Val Thr His Arg Ile Arg Lys Gln Ser Leu Gln 
            180                 185                 190         


Ser Gln Ile His Val Gln Arg Ile Pro Ile Ser Asn Val Ser Leu Glu 
        195                 200                 205             


Ile Arg Ala Pro Gly Gly Gln Val Thr Glu Gly Gln Lys Leu Ile Leu 
    210                 215                 220                 


Leu Cys Ser Val Ala Gly Gly Thr Gly Asn Val Thr Phe Ser Trp Tyr 
225                 230                 235                 240 


Arg Glu Ala Thr Gly Thr Ser Met Gly Lys Lys Thr Gln Arg Ser Leu 
                245                 250                 255     


Ser Ala Glu Leu Glu Ile Pro Ala Val Lys Glu Ser Asp Ala Gly Lys 
            260                 265                 270         


Tyr Tyr Cys Arg Ala Asp Asn Gly His Val Pro Ile Gln Ser Lys Val 
        275                 280                 285             


Val Asn Ile Pro Val Arg Ile Pro Val Ser Arg Pro Val Leu Thr Leu 
    290                 295                 300                 


Arg Ser Pro Gly Ala Gln Ala Ala Val Gly Asp Leu Leu Glu Leu His 
305                 310                 315                 320 


Cys Glu Ala Leu Arg Gly Ser Pro Pro Ile Leu Tyr Gln Phe Tyr His 
                325                 330                 335     


Glu Asp Val Thr Leu Gly Asn Ser Ser Ala Pro Ser Gly Gly Gly Ala 
            340                 345                 350         


Ser Phe Asn Leu Ser Leu Thr Ala Glu His Ser Gly Asn Tyr Ser Cys 
        355                 360                 365             


Glu Ala Asn Asn Gly Leu Gly Ala Gln Cys Ser Glu Ala Val Pro Val 
    370                 375                 380                 


Ser Ile Ser Gly Pro Asp Gly Tyr Arg Arg Asp Leu Met Thr Ala Gly 
385                 390                 395                 400 


Val Leu Trp Gly Leu Phe Gly Val Leu Gly Phe Thr Gly Val Ala Leu 
                405                 410                 415     


Leu Leu Tyr Ala Leu Phe His Lys Ile Ser Gly Glu Ser Ser Ala Thr 
            420                 425                 430         


Asn Glu Pro Arg Gly Ala Ser Arg Pro Asn Pro Gln Glu Phe Thr Tyr 
        435                 440                 445             


Ser Ser Pro Thr Pro Asp Met Glu Glu Leu Gln Pro Val Tyr Val Asn 
    450                 455                 460                 


Val Gly Ser Val Asp Val Asp Val Val Tyr Ser Gln Val Trp Ser Met 
465                 470                 475                 480 


Gln Gln Pro Glu Ser Ser Ala Asn Ile Arg Thr Leu Leu Glu Asn Lys 
                485                 490                 495     


Asp Ser Gln Val Ile Tyr Ser Ser Val Lys Lys Ser 
            500                 505             


<210>  5167
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  5167

Met Ser Leu Met Leu Asp Asp Gln Pro Pro Met Glu Ala Gln Tyr Ala 
1               5                   10                  15      


Glu Glu Gly Pro Gly Pro Gly Ile Phe Arg Ala Glu Pro Gly Asp Gln 
            20                  25                  30          


Gln His Pro Ile Ser Gln Ala Val Cys Trp Arg Ser Met Arg Arg Gly 
        35                  40                  45              


Cys Ala Val Leu Gly Ala Leu Gly Leu Leu Ala Gly Ala Gly Val Gly 
    50                  55                  60                  


Ser Trp Leu Leu Val Leu Tyr Leu Cys Pro Ala Ala Ser Gln Pro Ile 
65                  70                  75                  80  


Ser Gly Thr Leu Gln Asp Glu Glu Ile Thr Leu Ser Cys Ser Glu Ala 
                85                  90                  95      


Ser Ala Glu Glu Ala Leu Leu Pro Ala Leu Pro Lys Thr Val Ser Phe 
            100                 105                 110         


Arg Ile Asn Ser Glu Asp Phe Leu Leu Glu Ala Gln Val Arg Asp Gln 
        115                 120                 125             


Pro Arg Trp Leu Leu Val Cys His Glu Gly Trp Ser Pro Ala Leu Gly 
    130                 135                 140                 


Leu Gln Ile Cys Trp Ser Leu Gly His Leu Arg Leu Thr His His Lys 
145                 150                 155                 160 


Gly Val Asn Leu Thr Asp Ile Lys Leu Asn Ser Ser Gln Glu Phe Ala 
                165                 170                 175     


Gln Leu Ser Pro Arg Leu Gly Gly Phe Leu Glu Glu Ala Trp Gln Pro 
            180                 185                 190         


Arg Asn Asn Cys Thr Ser Gly Gln Val Val Ser Leu Arg Cys Ser Glu 
        195                 200                 205             


Cys Gly Ala Arg Pro Leu Ala Ser Arg Ile Val Gly Gly Gln Ser Val 
    210                 215                 220                 


Ala Pro Gly Arg Trp Pro Trp Gln Ala Ser Val Ala Leu Gly Phe Arg 
225                 230                 235                 240 


His Thr Cys Gly Gly Ser Val Leu Ala Pro Arg Trp Val Val Thr Ala 
                245                 250                 255     


Ala His Cys Met His Ser Phe Arg Leu Ala Arg Leu Ser Ser Trp Arg 
            260                 265                 270         


Val His Ala Gly Leu Val Ser His Ser Ala Val Arg Pro His Gln Gly 
        275                 280                 285             


Ala Leu Val Glu Arg Ile Ile Pro His Pro Leu Tyr Ser Ala Gln Asn 
    290                 295                 300                 


His Asp Tyr Asp Val Ala Leu Leu Arg Leu Gln Thr Ala Leu Asn Phe 
305                 310                 315                 320 


Ser Asp Thr Val Gly Ala Val Cys Leu Pro Ala Lys Glu Gln His Phe 
                325                 330                 335     


Pro Lys Gly Ser Arg Cys Trp Val Ser Gly Trp Gly His Thr His Pro 
            340                 345                 350         


Ser His Thr Tyr Ser Ser Asp Met Leu Gln Asp Thr Val Val Pro Leu 
        355                 360                 365             


Phe Ser Thr Gln Leu Cys Asn Ser Ser Cys Val Tyr Ser Gly Ala Leu 
    370                 375                 380                 


Thr Pro Arg Met Leu Cys Ala Gly Tyr Leu Asp Gly Arg Ala Asp Ala 
385                 390                 395                 400 


Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Pro Asp Gly Asp Thr 
                405                 410                 415     


Trp Arg Leu Val Gly Val Val Ser Trp Gly Arg Gly Cys Ala Glu Pro 
            420                 425                 430         


Asn His Pro Gly Val Tyr Ala Lys Val Ala Glu Phe Leu Asp Trp Ile 
        435                 440                 445             


His Asp Thr Ala Gln Asp Ser Leu Leu 
    450                 455         


<210>  5168
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  5168

Met Ser Ser Cys Asn Phe Thr His Ala Thr Phe Val Leu Ile Gly Ile 
1               5                   10                  15      


Pro Gly Leu Glu Lys Ala His Phe Trp Val Gly Phe Pro Leu Leu Ser 
            20                  25                  30          


Met Tyr Val Val Ala Met Phe Gly Asn Cys Ile Val Val Phe Ile Val 
        35                  40                  45              


Arg Thr Glu Arg Ser Leu His Ala Pro Met Tyr Leu Phe Leu Cys Met 
    50                  55                  60                  


Leu Ala Ala Ile Asp Leu Ala Leu Ser Thr Ser Thr Met Pro Lys Ile 
65                  70                  75                  80  


Leu Ala Leu Phe Trp Phe Asp Ser Arg Glu Ile Ser Phe Glu Ala Cys 
                85                  90                  95      


Leu Thr Gln Met Phe Phe Ile His Ala Leu Ser Ala Ile Glu Ser Thr 
            100                 105                 110         


Ile Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys His Pro 
        115                 120                 125             


Leu Arg His Ala Ala Val Leu Asn Asn Thr Val Thr Ala Gln Ile Gly 
    130                 135                 140                 


Ile Val Ala Val Val Arg Gly Ser Leu Phe Phe Phe Pro Leu Pro Leu 
145                 150                 155                 160 


Leu Ile Lys Arg Leu Ala Phe Cys His Ser Asn Val Leu Ser His Ser 
                165                 170                 175     


Tyr Cys Val His Gln Asp Val Met Lys Leu Ala Tyr Ala Asp Thr Leu 
            180                 185                 190         


Pro Asn Val Val Tyr Gly Leu Thr Ala Ile Leu Leu Val Met Gly Val 
        195                 200                 205             


Asp Val Met Phe Ile Ser Leu Ser Tyr Phe Leu Ile Ile Arg Thr Val 
    210                 215                 220                 


Leu Gln Leu Pro Ser Lys Ser Glu Arg Ala Lys Ala Phe Gly Thr Cys 
225                 230                 235                 240 


Val Ser His Ile Gly Val Val Leu Ala Phe Tyr Val Pro Leu Ile Gly 
                245                 250                 255     


Leu Ser Val Val His Arg Phe Gly Asn Ser Leu His Pro Ile Val Arg 
            260                 265                 270         


Val Val Met Gly Asp Ile Tyr Leu Leu Leu Pro Pro Val Ile Asn Pro 
        275                 280                 285             


Ile Ile Tyr Gly Ala Lys Thr Lys Gln Ile Arg Thr Arg Val Leu Ala 
    290                 295                 300                 


Met Phe Lys Ile Ser Cys Asp Lys Asp Leu Gln Ala Val Gly Gly Lys 
305                 310                 315                 320 


<210>  5169
<211>  541
<212>  PRT
<213>  Homo sapiens

<400>  5169

Met Gly His Ser Pro Pro Val Leu Pro Leu Cys Ala Ser Val Ser Leu 
1               5                   10                  15      


Leu Gly Gly Leu Thr Phe Gly Tyr Glu Leu Ala Val Ile Ser Gly Ala 
            20                  25                  30          


Leu Leu Pro Leu Gln Leu Asp Phe Gly Leu Ser Cys Leu Glu Gln Glu 
        35                  40                  45              


Phe Leu Val Gly Ser Leu Leu Leu Gly Ala Leu Leu Ala Ser Leu Val 
    50                  55                  60                  


Gly Gly Phe Leu Ile Asp Cys Tyr Gly Arg Lys Gln Ala Ile Leu Gly 
65                  70                  75                  80  


Ser Asn Leu Val Leu Leu Ala Gly Ser Leu Thr Leu Gly Leu Ala Gly 
                85                  90                  95      


Ser Leu Ala Trp Leu Val Leu Gly Arg Ala Val Val Gly Phe Ala Ile 
            100                 105                 110         


Ser Leu Ser Ser Met Ala Cys Cys Ile Tyr Val Ser Glu Leu Val Gly 
        115                 120                 125             


Pro Arg Gln Arg Gly Val Leu Val Ser Leu Tyr Glu Ala Gly Ile Thr 
    130                 135                 140                 


Val Gly Ile Leu Leu Ser Tyr Ala Leu Asn Tyr Ala Leu Ala Gly Thr 
145                 150                 155                 160 


Pro Trp Gly Trp Arg His Met Phe Gly Trp Ala Thr Ala Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Leu Ser Leu Leu Phe Leu Pro Ala Gly Thr Asp Glu Thr 
            180                 185                 190         


Ala Thr His Lys Asp Leu Ile Pro Leu Gln Gly Gly Glu Ala Pro Lys 
        195                 200                 205             


Leu Gly Pro Gly Arg Pro Arg Tyr Ser Phe Leu Asp Leu Phe Arg Ala 
    210                 215                 220                 


Arg Asp Asn Met Arg Gly Arg Thr Thr Val Gly Leu Gly Leu Val Leu 
225                 230                 235                 240 


Phe Gln Gln Leu Thr Gly Gln Pro Asn Val Leu Cys Tyr Ala Ser Thr 
                245                 250                 255     


Ile Phe Ser Ser Val Gly Phe His Gly Gly Ser Ser Ala Val Leu Ala 
            260                 265                 270         


Ser Val Gly Leu Gly Ala Val Lys Val Ala Ala Thr Leu Thr Ala Met 
        275                 280                 285             


Gly Leu Val Asp Arg Ala Gly Arg Arg Ala Leu Leu Leu Ala Gly Cys 
    290                 295                 300                 


Ala Leu Met Ala Leu Ser Val Ser Gly Ile Gly Leu Val Ser Phe Ala 
305                 310                 315                 320 


Val Pro Met Asp Ser Gly Pro Ser Cys Leu Ala Val Pro Asn Ala Thr 
                325                 330                 335     


Gly Gln Thr Gly Leu Pro Gly Asp Ser Gly Leu Leu Gln Asp Ser Ser 
            340                 345                 350         


Leu Pro Pro Ile Pro Arg Thr Asn Glu Asp Gln Arg Glu Pro Ile Leu 
        355                 360                 365             


Ser Thr Ala Lys Lys Thr Lys Pro His Pro Arg Ser Gly Asp Pro Ser 
    370                 375                 380                 


Ala Pro Pro Arg Leu Ala Leu Ser Ser Ala Leu Pro Gly Pro Pro Leu 
385                 390                 395                 400 


Pro Ala Arg Gly His Ala Leu Leu Arg Trp Thr Ala Leu Leu Cys Leu 
                405                 410                 415     


Met Val Phe Val Ser Ala Phe Ser Phe Gly Phe Gly Pro Val Thr Trp 
            420                 425                 430         


Leu Val Leu Ser Glu Ile Tyr Pro Val Glu Ile Arg Gly Arg Ala Phe 
        435                 440                 445             


Ala Phe Cys Asn Ser Phe Asn Trp Ala Ala Asn Leu Phe Ile Ser Leu 
    450                 455                 460                 


Ser Phe Leu Asp Leu Ile Gly Thr Ile Gly Leu Ser Trp Thr Phe Leu 
465                 470                 475                 480 


Leu Tyr Gly Leu Thr Ala Val Leu Gly Leu Gly Phe Ile Tyr Leu Phe 
                485                 490                 495     


Val Pro Glu Thr Lys Gly Gln Ser Leu Ala Glu Ile Asp Gln Gln Phe 
            500                 505                 510         


Gln Lys Arg Arg Phe Thr Leu Ser Phe Gly His Arg Gln Asn Ser Thr 
        515                 520                 525             


Gly Ile Pro Tyr Ser Arg Ile Glu Ile Ser Ala Ala Ser 
    530                 535                 540     


<210>  5170
<211>  994
<212>  PRT
<213>  Homo sapiens

<400>  5170

Met Pro Val Arg Arg Gly His Val Ala Pro Gln Asn Thr Tyr Leu Asp 
1               5                   10                  15      


Thr Ile Ile Arg Lys Phe Glu Gly Gln Ser Arg Lys Phe Leu Ile Ala 
            20                  25                  30          


Asn Ala Gln Met Glu Asn Cys Ala Ile Ile Tyr Cys Asn Asp Gly Phe 
        35                  40                  45              


Cys Glu Leu Phe Gly Tyr Ser Arg Val Glu Val Met Gln Gln Pro Cys 
    50                  55                  60                  


Thr Cys Asp Phe Leu Thr Gly Pro Asn Thr Pro Ser Ser Ala Val Ser 
65                  70                  75                  80  


Arg Leu Ala Gln Ala Leu Leu Gly Ala Glu Glu Cys Lys Val Asp Ile 
                85                  90                  95      


Leu Tyr Tyr Arg Lys Asp Ala Ser Ser Phe Arg Cys Leu Val Asp Val 
            100                 105                 110         


Val Pro Val Lys Asn Glu Asp Gly Ala Val Ile Met Phe Ile Leu Asn 
        115                 120                 125             


Phe Glu Asp Leu Ala Gln Leu Leu Ala Lys Cys Ser Ser Arg Ser Leu 
    130                 135                 140                 


Ser Gln Arg Leu Leu Ser Gln Ser Phe Leu Gly Ser Glu Gly Ser His 
145                 150                 155                 160 


Gly Arg Pro Gly Gly Pro Gly Pro Gly Thr Gly Arg Gly Lys Tyr Arg 
                165                 170                 175     


Thr Ile Ser Gln Ile Pro Gln Phe Thr Leu Asn Phe Val Glu Phe Asn 
            180                 185                 190         


Leu Glu Lys His Arg Ser Ser Ser Thr Thr Glu Ile Glu Ile Ile Ala 
        195                 200                 205             


Pro His Lys Val Val Glu Arg Thr Gln Asn Val Thr Glu Lys Val Thr 
    210                 215                 220                 


Gln Val Leu Ser Leu Gly Ala Asp Val Leu Pro Glu Tyr Lys Leu Gln 
225                 230                 235                 240 


Ala Pro Arg Ile His Arg Trp Thr Ile Leu His Tyr Ser Pro Phe Lys 
                245                 250                 255     


Ala Val Trp Asp Trp Leu Ile Leu Leu Leu Val Ile Tyr Thr Ala Val 
            260                 265                 270         


Phe Thr Pro Tyr Ser Ala Ala Phe Leu Leu Ser Asp Gln Asp Glu Ser 
        275                 280                 285             


Arg Arg Gly Ala Cys Ser Tyr Thr Cys Ser Pro Leu Thr Val Val Asp 
    290                 295                 300                 


Leu Ile Val Asp Ile Met Phe Val Val Asp Ile Val Ile Asn Phe Arg 
305                 310                 315                 320 


Thr Thr Tyr Val Asn Thr Asn Asp Glu Val Val Ser His Pro Arg Arg 
                325                 330                 335     


Ile Ala Val His Tyr Phe Lys Gly Trp Phe Leu Ile Asp Met Val Ala 
            340                 345                 350         


Ala Ile Pro Phe Asp Leu Leu Ile Phe Arg Thr Gly Ser Asp Glu Thr 
        355                 360                 365             


Thr Thr Leu Ile Gly Leu Leu Lys Thr Ala Arg Leu Leu Arg Leu Val 
    370                 375                 380                 


Arg Val Ala Arg Lys Leu Asp Arg Tyr Ser Glu Tyr Gly Ala Ala Val 
385                 390                 395                 400 


Leu Phe Leu Leu Met Cys Thr Phe Ala Leu Ile Ala His Trp Leu Ala 
                405                 410                 415     


Cys Ile Trp Tyr Ala Ile Gly Asn Val Glu Arg Pro Tyr Leu Glu His 
            420                 425                 430         


Lys Ile Gly Trp Leu Asp Ser Leu Gly Val Gln Leu Gly Lys Arg Tyr 
        435                 440                 445             


Asn Gly Ser Asp Pro Ala Ser Gly Pro Ser Val Gln Asp Lys Tyr Val 
    450                 455                 460                 


Thr Ala Leu Tyr Phe Thr Phe Ser Ser Leu Thr Ser Val Gly Phe Gly 
465                 470                 475                 480 


Asn Val Ser Pro Asn Thr Asn Ser Glu Lys Val Phe Ser Ile Cys Val 
                485                 490                 495     


Met Leu Ile Gly Ser Leu Met Tyr Ala Ser Ile Phe Gly Asn Val Ser 
            500                 505                 510         


Ala Ile Ile Gln Arg Leu Tyr Ser Gly Thr Ala Arg Tyr His Thr Gln 
        515                 520                 525             


Met Leu Arg Val Lys Glu Phe Ile Arg Phe His Gln Ile Pro Asn Pro 
    530                 535                 540                 


Leu Arg Gln Arg Leu Glu Glu Tyr Phe Gln His Ala Trp Ser Tyr Thr 
545                 550                 555                 560 


Asn Gly Ile Asp Met Asn Ala Val Leu Lys Gly Phe Pro Glu Cys Leu 
                565                 570                 575     


Gln Ala Asp Ile Cys Leu His Leu His Arg Ala Leu Leu Gln His Cys 
            580                 585                 590         


Pro Ala Phe Ser Gly Ala Gly Lys Gly Cys Leu Arg Ala Leu Ala Val 
        595                 600                 605             


Lys Phe Lys Thr Thr His Ala Pro Pro Gly Asp Thr Leu Val His Leu 
    610                 615                 620                 


Gly Asp Val Leu Ser Thr Leu Tyr Phe Ile Ser Arg Gly Ser Ile Glu 
625                 630                 635                 640 


Ile Leu Arg Asp Asp Val Val Val Ala Ile Leu Gly Lys Asn Asp Ile 
                645                 650                 655     


Phe Gly Glu Pro Val Ser Leu His Ala Gln Pro Gly Lys Ser Ser Ala 
            660                 665                 670         


Asp Val Arg Ala Leu Thr Tyr Cys Asp Leu His Lys Ile Gln Arg Ala 
        675                 680                 685             


Asp Leu Leu Glu Val Leu Asp Met Tyr Pro Ala Phe Ala Glu Ser Phe 
    690                 695                 700                 


Trp Ser Lys Leu Glu Val Thr Phe Asn Leu Arg Asp Ala Ala Gly Gly 
705                 710                 715                 720 


Leu His Ser Ser Pro Arg Gln Ala Pro Gly Ser Gln Asp His Gln Gly 
                725                 730                 735     


Phe Phe Leu Ser Asp Asn Gln Ser Gly Ser Pro His Glu Leu Gly Pro 
            740                 745                 750         


Gln Phe Pro Ser Lys Gly Tyr Ser Leu Leu Gly Pro Gly Ser Gln Asn 
        755                 760                 765             


Ser Met Gly Ala Gly Pro Cys Ala Pro Gly His Pro Asp Ala Ala Pro 
    770                 775                 780                 


Pro Leu Ser Ile Ser Asp Ala Ser Gly Leu Trp Pro Glu Leu Leu Gln 
785                 790                 795                 800 


Glu Met Pro Pro Arg His Ser Pro Gln Ser Pro Gln Glu Asp Pro Asp 
                805                 810                 815     


Cys Trp Pro Leu Lys Leu Gly Ser Arg Leu Glu Gln Leu Gln Ala Gln 
            820                 825                 830         


Met Asn Arg Leu Glu Ser Arg Val Ser Ser Asp Leu Ser Arg Ile Leu 
        835                 840                 845             


Gln Leu Leu Gln Lys Pro Met Pro Gln Gly His Ala Ser Tyr Ile Leu 
    850                 855                 860                 


Glu Ala Pro Ala Ser Asn Asp Leu Ala Leu Val Pro Ile Ala Ser Glu 
865                 870                 875                 880 


Thr Thr Ser Pro Gly Pro Arg Leu Pro Gln Gly Phe Leu Pro Pro Ala 
                885                 890                 895     


Gln Thr Pro Ser Tyr Gly Asp Leu Asp Asp Cys Ser Pro Lys His Arg 
            900                 905                 910         


Asn Ser Ser Pro Arg Met Pro His Leu Ala Val Ala Thr Asp Lys Thr 
        915                 920                 925             


Leu Ala Pro Ser Ser Glu Gln Glu Gln Pro Glu Gly Leu Trp Pro Pro 
    930                 935                 940                 


Leu Ala Ser Pro Leu His Pro Leu Glu Val Gln Gly Leu Ile Cys Gly 
945                 950                 955                 960 


Pro Cys Phe Ser Ser Leu Pro Glu His Leu Gly Ser Val Pro Lys Gln 
                965                 970                 975     


Leu Asp Phe Gln Arg His Gly Ser Asp Pro Gly Phe Ala Gly Ser Trp 
            980                 985                 990         


Gly His 
        


<210>  5171
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  5171

Met Trp Ser Gly Arg Ser Ser Phe Thr Ser Leu Val Val Gly Val Phe 
1               5                   10                  15      


Val Val Tyr Val Val His Thr Cys Trp Val Met Tyr Gly Ile Val Tyr 
            20                  25                  30          


Thr Arg Pro Cys Ser Gly Asp Ala Asn Cys Ile Gln Pro Tyr Leu Ala 
        35                  40                  45              


Arg Arg Pro Lys Leu Gln Leu Ser Val Tyr Thr Thr Thr Arg Ser His 
    50                  55                  60                  


Leu Gly Ala Glu Asn Asn Ile Asp Leu Val Leu Asn Val Glu Asp Phe 
65                  70                  75                  80  


Asp Val Glu Ser Lys Phe Glu Arg Thr Val Asn Val Ser Val Pro Lys 
                85                  90                  95      


Lys Thr Arg Asn Asn Gly Thr Leu Tyr Ala Tyr Ile Phe Leu His His 
            100                 105                 110         


Ala Gly Val Leu Pro Trp His Asp Gly Lys Gln Val His Leu Val Ser 
        115                 120                 125             


Pro Leu Thr Thr Tyr Met Val Pro Lys Pro Glu Glu Ile Asn Leu Leu 
    130                 135                 140                 


Thr Gly Glu Ser Asp Thr Gln Gln Ile Glu Ala Glu Lys Lys Pro Thr 
145                 150                 155                 160 


Ser Ala Leu Asp Glu Pro Val Ser His Trp Arg Pro Arg Leu Ala Leu 
                165                 170                 175     


Asn Val Met Ala Asp Asn Phe Val Phe Asp Gly Ser Ser Leu Pro Ala 
            180                 185                 190         


Asp Val His Arg Tyr Met Lys Met Ile Gln Leu Gly Lys Thr Val His 
        195                 200                 205             


Tyr Leu Pro Ile Leu Phe Ile Asp Gln Leu Ser Asn Arg Val Lys Asp 
    210                 215                 220                 


Leu Met Val Ile Asn Arg Ser Thr Thr Glu Leu Pro Leu Thr Val Ser 
225                 230                 235                 240 


Tyr Asp Lys Val Ser Leu Gly Arg Leu Arg Phe Trp Ile His Met Gln 
                245                 250                 255     


Asp Ala Val Tyr Ser Leu Gln Gln Phe Gly Phe Ser Glu Lys Asp Ala 
            260                 265                 270         


Asp Glu Val Lys Gly Ile Phe Val Asp Thr Asn Leu Tyr Phe Leu Ala 
        275                 280                 285             


Leu Thr Phe Phe Val Ala Ala Phe His Leu Leu Phe Asp Phe Leu Ala 
    290                 295                 300                 


Phe Lys Asn Asp Ile Ser Phe Trp Lys Lys Lys Lys Ser Met Ile Gly 
305                 310                 315                 320 


Met Ser Thr Lys Ala Val Leu Trp Arg Cys Phe Ser Thr Val Val Ile 
                325                 330                 335     


Phe Leu Phe Leu Leu Asp Glu Gln Thr Ser Leu Leu Val Leu Val Pro 
            340                 345                 350         


Ala Gly Val Gly Ala Ala Ile Glu Leu Trp Lys Val Lys Lys Ala Leu 
        355                 360                 365             


Lys Met Thr Ile Phe Trp Arg Gly Leu Met Pro Glu Phe Gln Phe Gly 
    370                 375                 380                 


Thr Tyr Ser Glu Ser Glu Arg Lys Thr Glu Glu Tyr Asp Thr Gln Ala 
385                 390                 395                 400 


Met Lys Tyr Leu Ser Tyr Leu Leu Tyr Pro Leu Cys Val Gly Gly Ala 
                405                 410                 415     


Val Tyr Ser Leu Leu Asn Ile Lys Tyr Lys Ser Trp Tyr Ser Trp Leu 
            420                 425                 430         


Ile Asn Ser Phe Val Asn Gly Val Tyr Ala Phe Gly Phe Leu Phe Met 
        435                 440                 445             


Leu Pro Gln Leu Phe Val Asn Tyr Lys Leu Lys Ser Val Ala His Leu 
    450                 455                 460                 


Pro Trp Lys Ala Phe Thr Tyr Lys Ala Phe Asn Thr Phe Ile Asp Asp 
465                 470                 475                 480 


Val Phe Ala Phe Ile Ile Thr Met Pro Thr Ser His Arg Leu Ala Cys 
                485                 490                 495     


Phe Arg Asp Asp Val Val Phe Leu Val Tyr Leu Tyr Gln Arg Trp Leu 
            500                 505                 510         


Tyr Pro Val Asp Lys Arg Arg Val Asn Glu Phe Gly Glu Ser Tyr Glu 
        515                 520                 525             


Glu Lys Ala Thr Arg Ala Pro His Thr Asp 
    530                 535             


<210>  5172
<211>  487
<212>  PRT
<213>  Homo sapiens

<400>  5172

Met Arg Arg Gly Glu Arg Arg Asp Ala Gly Gly Pro Arg Pro Glu Ser 
1               5                   10                  15      


Pro Val Pro Ala Gly Arg Ala Ser Leu Glu Glu Pro Pro Asp Gly Pro 
            20                  25                  30          


Ser Ala Gly Gln Ala Thr Gly Pro Gly Glu Gly Arg Arg Ser Thr Glu 
        35                  40                  45              


Ser Glu Val Tyr Asp Asp Gly Thr Asn Thr Phe Phe Trp Arg Ala His 
    50                  55                  60                  


Thr Leu Thr Val Leu Phe Ile Leu Thr Cys Thr Leu Gly Tyr Val Thr 
65                  70                  75                  80  


Leu Leu Glu Glu Thr Pro Gln Asp Thr Ala Tyr Asn Thr Lys Arg Gly 
                85                  90                  95      


Ile Val Ala Ser Ile Leu Val Phe Leu Cys Phe Gly Val Thr Gln Ala 
            100                 105                 110         


Lys Asp Gly Pro Phe Ser Arg Pro His Pro Ala Tyr Trp Arg Phe Trp 
        115                 120                 125             


Leu Cys Val Ser Val Val Tyr Glu Leu Phe Leu Ile Phe Ile Leu Phe 
    130                 135                 140                 


Gln Thr Val Gln Asp Gly Arg Gln Phe Leu Lys Tyr Val Asp Pro Lys 
145                 150                 155                 160 


Leu Gly Val Pro Leu Pro Glu Arg Asp Tyr Gly Gly Asn Cys Leu Ile 
                165                 170                 175     


Tyr Asp Pro Asp Asn Glu Thr Asp Pro Phe His Asn Ile Trp Asp Lys 
            180                 185                 190         


Leu Asp Gly Phe Val Pro Ala His Phe Leu Gly Trp Tyr Leu Lys Thr 
        195                 200                 205             


Leu Met Ile Arg Asp Trp Trp Met Cys Met Ile Ile Ser Val Met Phe 
    210                 215                 220                 


Glu Phe Leu Glu Tyr Ser Leu Glu His Gln Leu Pro Asn Phe Ser Glu 
225                 230                 235                 240 


Cys Trp Trp Asp His Trp Ile Met Asp Val Leu Val Cys Asn Gly Leu 
                245                 250                 255     


Gly Ile Tyr Cys Gly Met Lys Thr Leu Glu Trp Leu Ser Leu Lys Thr 
            260                 265                 270         


Tyr Lys Trp Gln Gly Leu Trp Asn Ile Pro Thr Tyr Lys Gly Lys Met 
        275                 280                 285             


Lys Arg Ile Ala Phe Gln Phe Thr Pro Tyr Ser Trp Val Arg Phe Glu 
    290                 295                 300                 


Trp Lys Pro Ala Ser Ser Leu Arg Arg Trp Leu Ala Val Cys Gly Ile 
305                 310                 315                 320 


Ile Leu Val Phe Leu Leu Ala Glu Leu Asn Thr Phe Tyr Leu Lys Phe 
                325                 330                 335     


Val Leu Trp Met Pro Pro Glu His Tyr Leu Val Leu Leu Arg Leu Val 
            340                 345                 350         


Phe Phe Val Asn Val Gly Gly Val Ala Met Arg Glu Ile Tyr Asp Phe 
        355                 360                 365             


Met Asp Asp Pro Lys Pro His Lys Lys Leu Gly Pro Gln Ala Trp Leu 
    370                 375                 380                 


Val Ala Ala Ile Thr Ala Thr Glu Leu Leu Ile Val Val Lys Tyr Asp 
385                 390                 395                 400 


Pro His Thr Leu Thr Leu Ser Leu Pro Phe Tyr Ile Ser Gln Cys Trp 
                405                 410                 415     


Thr Leu Gly Ser Val Leu Ala Leu Thr Trp Thr Val Trp Arg Phe Phe 
            420                 425                 430         


Leu Arg Asp Ile Thr Leu Arg Tyr Lys Glu Thr Arg Trp Gln Lys Trp 
        435                 440                 445             


Gln Asn Lys Asp Asp Gln Gly Ser Thr Val Gly Asn Gly Asp Gln His 
    450                 455                 460                 


Pro Leu Gly Leu Asp Glu Asp Leu Leu Gly Pro Gly Val Ala Glu Gly 
465                 470                 475                 480 


Glu Gly Ala Pro Thr Pro Asn 
                485         


<210>  5173
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  5173

Met Val Phe Ser Ala Val Leu Thr Ala Phe His Thr Gly Thr Ser Asn 
1               5                   10                  15      


Thr Thr Phe Val Val Tyr Glu Asn Thr Tyr Met Asn Ile Thr Leu Pro 
            20                  25                  30          


Pro Pro Phe Gln His Pro Asp Leu Ser Pro Leu Leu Arg Tyr Ser Phe 
        35                  40                  45              


Glu Thr Met Ala Pro Thr Gly Leu Ser Ser Leu Thr Val Asn Ser Thr 
    50                  55                  60                  


Ala Val Pro Thr Thr Pro Ala Ala Phe Lys Ser Leu Asn Leu Pro Leu 
65                  70                  75                  80  


Gln Ile Thr Leu Ser Ala Ile Met Ile Phe Ile Leu Phe Val Ser Phe 
                85                  90                  95      


Leu Gly Asn Leu Val Val Cys Leu Met Val Tyr Gln Lys Ala Ala Met 
            100                 105                 110         


Arg Ser Ala Ile Asn Ile Leu Leu Ala Ser Leu Ala Phe Ala Asp Met 
        115                 120                 125             


Leu Leu Ala Val Leu Asn Met Pro Phe Ala Leu Val Thr Ile Leu Thr 
    130                 135                 140                 


Thr Arg Trp Ile Phe Gly Lys Phe Phe Cys Arg Val Ser Ala Met Phe 
145                 150                 155                 160 


Phe Trp Leu Phe Val Ile Glu Gly Val Ala Ile Leu Leu Ile Ile Ser 
                165                 170                 175     


Ile Asp Arg Phe Leu Ile Ile Val Gln Arg Gln Asp Lys Leu Asn Pro 
            180                 185                 190         


Tyr Arg Ala Lys Val Leu Ile Ala Val Ser Trp Ala Thr Ser Phe Cys 
        195                 200                 205             


Val Ala Phe Pro Leu Ala Val Gly Asn Pro Asp Leu Gln Ile Pro Ser 
    210                 215                 220                 


Arg Ala Pro Gln Cys Val Phe Gly Tyr Thr Thr Asn Pro Gly Tyr Gln 
225                 230                 235                 240 


Ala Tyr Val Ile Leu Ile Ser Leu Ile Ser Phe Phe Ile Pro Phe Leu 
                245                 250                 255     


Val Ile Leu Tyr Ser Phe Met Gly Ile Leu Asn Thr Leu Arg His Asn 
            260                 265                 270         


Ala Leu Arg Ile His Ser Tyr Pro Glu Gly Ile Cys Leu Ser Gln Ala 
        275                 280                 285             


Ser Lys Leu Gly Leu Met Ser Leu Gln Arg Pro Phe Gln Met Ser Ile 
    290                 295                 300                 


Asp Met Gly Phe Lys Thr Arg Ala Phe Thr Thr Ile Leu Ile Leu Phe 
305                 310                 315                 320 


Ala Val Phe Ile Val Cys Trp Ala Pro Phe Thr Thr Tyr Ser Leu Val 
                325                 330                 335     


Ala Thr Phe Ser Lys His Phe Tyr Tyr Gln His Asn Phe Phe Glu Ile 
            340                 345                 350         


Ser Thr Trp Leu Leu Trp Leu Cys Tyr Leu Lys Ser Ala Leu Asn Pro 
        355                 360                 365             


Leu Ile Tyr Tyr Trp Arg Ile Lys Lys Phe His Asp Ala Cys Leu Asp 
    370                 375                 380                 


Met Met Pro Lys Ser Phe Lys Phe Leu Pro Gln Leu Pro Gly His Thr 
385                 390                 395                 400 


Lys Arg Arg Ile Arg Pro Ser Ala Val Tyr Val Cys Gly Glu His Arg 
                405                 410                 415     


Thr Val Val 
            


<210>  5174
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  5174

Met Asp Ser Ala Leu Ser Asp Pro His Asn Gly Ser Ala Glu Ala Gly 
1               5                   10                  15      


Gly Pro Thr Asn Ser Thr Thr Arg Pro Pro Ser Thr Pro Glu Gly Ile 
            20                  25                  30          


Ala Leu Ala Tyr Gly Ser Leu Leu Leu Met Ala Leu Leu Pro Ile Phe 
        35                  40                  45              


Phe Gly Ala Leu Arg Ser Val Arg Cys Ala Arg Gly Lys Asn Ala Ser 
    50                  55                  60                  


Asp Met Pro Glu Thr Ile Thr Ser Arg Asp Ala Ala Arg Phe Pro Ile 
65                  70                  75                  80  


Ile Ala Ser Cys Thr Leu Leu Gly Leu Tyr Leu Phe Phe Lys Ile Phe 
                85                  90                  95      


Ser Gln Glu Tyr Ile Asn Leu Leu Leu Ser Met Tyr Phe Phe Val Leu 
            100                 105                 110         


Gly Ile Leu Ala Leu Ser His Thr Ile Ser Pro Phe Met Asn Lys Phe 
        115                 120                 125             


Phe Pro Ala Ser Phe Pro Asn Arg Gln Tyr Gln Leu Leu Phe Thr Gln 
    130                 135                 140                 


Gly Ser Gly Glu Asn Lys Glu Glu Ile Ile Asn Tyr Glu Phe Asp Thr 
145                 150                 155                 160 


Lys Asp Leu Val Cys Leu Gly Leu Ser Ser Ile Val Gly Val Trp Tyr 
                165                 170                 175     


Leu Leu Arg Lys His Trp Ile Ala Asn Asn Leu Phe Gly Leu Ala Phe 
            180                 185                 190         


Ser Leu Asn Gly Val Glu Leu Leu His Leu Asn Asn Val Ser Thr Gly 
        195                 200                 205             


Cys Ile Leu Leu Gly Gly Leu Phe Ile Tyr Asp Val Phe Trp Val Phe 
    210                 215                 220                 


Gly Thr Asn Val Met Val Thr Val Ala Lys Ser Phe Glu Ala Pro Ile 
225                 230                 235                 240 


Lys Leu Val Phe Pro Gln Asp Leu Leu Glu Lys Gly Leu Glu Ala Asn 
                245                 250                 255     


Asn Phe Ala Met Leu Gly Leu Gly Asp Val Val Ile Pro Gly Ile Phe 
            260                 265                 270         


Ile Ala Leu Leu Leu Arg Phe Asp Ile Ser Leu Lys Lys Asn Thr His 
        275                 280                 285             


Thr Tyr Phe Tyr Thr Ser Phe Ala Ala Tyr Ile Phe Gly Leu Gly Leu 
    290                 295                 300                 


Thr Ile Phe Ile Met His Ile Phe Lys His Ala Gln Pro Ala Leu Leu 
305                 310                 315                 320 


Tyr Leu Val Pro Ala Cys Ile Gly Phe Pro Val Leu Val Ala Leu Ala 
                325                 330                 335     


Lys Gly Glu Val Thr Glu Met Phe Ser Tyr Glu Glu Ser Asn Pro Lys 
            340                 345                 350         


Asp Pro Ala Ala Val Thr Glu Ser Lys Glu Gly Thr Glu Ala Ser Ala 
        355                 360                 365             


Ser Lys Gly Leu Glu Lys Lys Glu Lys 
    370                 375         


<210>  5175
<211>  612
<212>  PRT
<213>  Homo sapiens

<400>  5175

Met Ala Ala Ala Gly Arg Leu Pro Ser Ser Trp Ala Leu Phe Ser Pro 
1               5                   10                  15      


Leu Leu Ala Gly Leu Ala Leu Leu Gly Val Gly Pro Val Pro Ala Arg 
            20                  25                  30          


Ala Leu His Asn Val Thr Ala Glu Leu Phe Gly Ala Glu Ala Trp Gly 
        35                  40                  45              


Thr Leu Ala Ala Phe Gly Asp Leu Asn Ser Asp Lys Gln Thr Asp Leu 
    50                  55                  60                  


Phe Val Leu Arg Glu Arg Asn Asp Leu Ile Val Phe Leu Ala Asp Gln 
65                  70                  75                  80  


Asn Ala Pro Tyr Phe Lys Pro Lys Val Lys Val Ser Phe Lys Asn His 
                85                  90                  95      


Ser Ala Leu Ile Thr Ser Val Val Pro Gly Asp Tyr Asp Gly Asp Ser 
            100                 105                 110         


Gln Met Asp Val Leu Leu Thr Tyr Leu Pro Lys Asn Tyr Ala Lys Ser 
        115                 120                 125             


Glu Leu Gly Ala Val Ile Phe Trp Gly Gln Asn Gln Thr Leu Asp Pro 
    130                 135                 140                 


Asn Asn Met Thr Ile Leu Asn Arg Thr Phe Gln Asp Glu Pro Leu Ile 
145                 150                 155                 160 


Met Asp Phe Asn Gly Asp Leu Ile Pro Asp Ile Phe Gly Ile Thr Asn 
                165                 170                 175     


Glu Ser Asn Gln Pro Gln Ile Leu Leu Gly Gly Asn Leu Ser Trp His 
            180                 185                 190         


Pro Ala Leu Thr Thr Thr Ser Lys Met Arg Ile Pro His Ser His Ala 
        195                 200                 205             


Phe Ile Asp Leu Thr Glu Asp Phe Thr Ala Asp Leu Phe Leu Thr Thr 
    210                 215                 220                 


Leu Asn Ala Thr Thr Ser Thr Phe Gln Phe Glu Ile Trp Glu Asn Leu 
225                 230                 235                 240 


Asp Gly Asn Phe Ser Val Ser Thr Ile Leu Glu Lys Pro Gln Asn Met 
                245                 250                 255     


Met Val Val Gly Gln Ser Ala Phe Ala Asp Phe Asp Gly Asp Gly His 
            260                 265                 270         


Met Asp His Leu Leu Pro Gly Cys Glu Asp Lys Asn Cys Gln Lys Ser 
        275                 280                 285             


Thr Ile Tyr Leu Val Arg Ser Gly Met Lys Gln Trp Val Pro Val Leu 
    290                 295                 300                 


Gln Asp Phe Ser Asn Lys Gly Thr Leu Trp Gly Phe Val Pro Phe Val 
305                 310                 315                 320 


Asp Glu Gln Gln Pro Thr Glu Ile Pro Ile Pro Ile Thr Leu His Ile 
                325                 330                 335     


Gly Asp Tyr Asn Met Asp Gly Tyr Pro Asp Ala Leu Val Ile Leu Lys 
            340                 345                 350         


Asn Thr Ser Gly Ser Asn Gln Gln Ala Phe Leu Leu Glu Asn Val Pro 
        355                 360                 365             


Cys Asn Asn Ala Ser Cys Glu Glu Ala Arg Arg Met Phe Lys Val Tyr 
    370                 375                 380                 


Trp Glu Leu Thr Asp Leu Asn Gln Ile Lys Asp Ala Met Val Ala Thr 
385                 390                 395                 400 


Phe Phe Asp Ile Tyr Glu Asp Gly Ile Leu Asp Ile Val Val Leu Ser 
                405                 410                 415     


Lys Gly Tyr Thr Lys Asn Asp Phe Ala Ile His Thr Leu Lys Asn Asn 
            420                 425                 430         


Phe Glu Ala Asp Ala Tyr Phe Val Lys Val Ile Val Leu Ser Gly Leu 
        435                 440                 445             


Cys Ser Asn Asp Cys Pro Arg Lys Ile Thr Pro Phe Gly Val Asn Gln 
    450                 455                 460                 


Pro Gly Pro Tyr Ile Met Tyr Thr Thr Val Asp Ala Asn Gly Tyr Leu 
465                 470                 475                 480 


Lys Asn Gly Ser Ala Gly Gln Leu Ser Gln Ser Ala His Leu Ala Leu 
                485                 490                 495     


Gln Leu Pro Tyr Asn Val Leu Gly Leu Gly Arg Ser Ala Asn Phe Leu 
            500                 505                 510         


Asp His Leu Tyr Val Gly Ile Pro Arg Pro Ser Gly Glu Lys Ser Ile 
        515                 520                 525             


Arg Lys Gln Glu Trp Thr Ala Ile Ile Pro Asn Ser Gln Leu Ile Val 
    530                 535                 540                 


Ile Pro Tyr Pro His Asn Val Pro Arg Ser Trp Ser Ala Lys Leu Tyr 
545                 550                 555                 560 


Leu Thr Pro Ser Asn Ile Val Leu Leu Thr Ala Ile Ala Leu Ile Gly 
                565                 570                 575     


Val Cys Val Phe Ile Leu Ala Ile Ile Gly Ile Leu His Trp Gln Glu 
            580                 585                 590         


Lys Lys Ala Asp Asp Arg Glu Lys Arg Gln Glu Ala His Arg Phe His 
        595                 600                 605             


Phe Asp Ala Met 
    610         


<210>  5176
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  5176

Met Ser Leu Arg Gln Arg Leu Ala Gln Leu Val Gly Arg Leu Gln Asp 
1               5                   10                  15      


Pro Gln Lys Val Ala Arg Phe Gln Arg Leu Cys Gly Val Glu Ala Pro 
            20                  25                  30          


Pro Arg Arg Ser Ala Asp Arg Arg Glu Asp Glu Lys Ala Glu Ala Pro 
        35                  40                  45              


Leu Ala Gly Asp Pro Arg Leu Arg Gly Arg Gln Pro Gly Ala Pro Gly 
    50                  55                  60                  


Gly Pro Gln Pro Pro Gly Ser Asp Arg Asn Gln Cys Pro Ala Lys Pro 
65                  70                  75                  80  


Asp Gly Gly Gly Ala Pro Asn Gly Val Arg Asn Gly Leu Ala Ala Glu 
                85                  90                  95      


Leu Gly Pro Ala Ser Pro Arg Arg Ala Gly Ala Leu Arg Arg Asn Ser 
            100                 105                 110         


Leu Thr Gly Glu Glu Gly Gln Leu Ala Arg Val Ser Asn Trp Pro Leu 
        115                 120                 125             


Tyr Cys Leu Phe Cys Phe Gly Thr Glu Leu Gly Asn Glu Leu Phe Tyr 
    130                 135                 140                 


Ile Leu Phe Phe Pro Phe Trp Ile Trp Asn Leu Asp Pro Leu Val Gly 
145                 150                 155                 160 


Arg Arg Leu Val Val Ile Trp Val Leu Val Met Tyr Leu Gly Gln Cys 
                165                 170                 175     


Thr Lys Asp Ile Ile Arg Trp Pro Arg Pro Ala Ser Pro Pro Val Val 
            180                 185                 190         


Lys Leu Glu Val Phe Tyr Asn Ser Glu Tyr Ser Met Pro Ser Thr His 
        195                 200                 205             


Ala Met Ser Gly Thr Ala Ile Pro Ile Ser Met Val Leu Leu Thr Tyr 
    210                 215                 220                 


Gly Arg Trp Gln Tyr Pro Leu Ile Tyr Gly Leu Ile Leu Ile Pro Cys 
225                 230                 235                 240 


Trp Cys Ser Leu Val Cys Leu Ser Arg Ile Tyr Met Gly Met His Ser 
                245                 250                 255     


Ile Leu Asp Ile Ile Ala Gly Phe Leu Tyr Thr Ile Leu Ile Leu Ala 
            260                 265                 270         


Val Phe Tyr Pro Phe Val Asp Leu Ile Asp Asn Phe Asn Gln Thr His 
        275                 280                 285             


Lys Tyr Ala Pro Phe Ile Ile Ile Gly Leu His Leu Ala Leu Gly Ile 
    290                 295                 300                 


Phe Ser Phe Thr Leu Asp Thr Trp Ser Thr Ser Arg Gly Asp Thr Ala 
305                 310                 315                 320 


Glu Ile Leu Gly Ser Gly Ala Gly Ile Ala Cys Gly Ser His Val Thr 
                325                 330                 335     


Tyr Asn Met Gly Leu Val Leu Asp Pro Ser Leu Asp Thr Leu Pro Leu 
            340                 345                 350         


Ala Gly Pro Pro Ile Thr Val Thr Leu Phe Gly Lys Ala Ile Leu Arg 
        355                 360                 365             


Ile Leu Ile Gly Met Val Phe Val Leu Ile Ile Arg Asp Val Met Lys 
    370                 375                 380                 


Lys Ile Thr Ile Pro Leu Ala Cys Lys Ile Phe Asn Ile Pro Cys Asp 
385                 390                 395                 400 


Asp Ile Arg Lys Ala Arg Gln His Met Glu Val Glu Leu Pro Tyr Arg 
                405                 410                 415     


Tyr Ile Thr Tyr Gly Met Val Gly Phe Ser Ile Thr Phe Phe Val Pro 
            420                 425                 430         


Tyr Ile Phe Phe Phe Ile Gly Ile Ser 
        435                 440     


<210>  5177
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  5177

Met Val Arg His Gln Pro Leu Gln Tyr Tyr Glu Pro Gln Leu Cys Leu 
1               5                   10                  15      


Ser Cys Leu Thr Gly Ile Tyr Gly Cys Arg Trp Lys Arg Tyr Gln Arg 
            20                  25                  30          


Ser His Asp Asp Thr Thr Pro Trp Glu Arg Leu Trp Phe Leu Leu Leu 
        35                  40                  45              


Thr Phe Thr Phe Gly Leu Thr Leu Thr Trp Leu Tyr Phe Trp Trp Glu 
    50                  55                  60                  


Val His Asn Asp Tyr Asp Glu Phe Asn Trp Tyr Leu Tyr Asn Arg Met 
65                  70                  75                  80  


Gly Tyr Trp Ser Asp Trp Pro Val Pro Ile Leu Val Thr Thr Ala Ala 
                85                  90                  95      


Ala Phe Ala Tyr Ile Ala Gly Leu Leu Val Leu Ala Leu Cys His Ile 
            100                 105                 110         


Ala Val Gly Gln Gln Met Asn Leu His Trp Leu His Lys Ile Gly Leu 
        115                 120                 125             


Val Val Ile Leu Ala Ser Thr Val Val Ala Met Ser Ala Val Ala Gln 
    130                 135                 140                 


Leu Trp Glu Asp Glu Trp Glu Val Leu Leu Ile Ser Leu Gln Gly Thr 
145                 150                 155                 160 


Ala Pro Phe Leu His Val Gly Ala Val Ala Ala Val Thr Met Leu Ser 
                165                 170                 175     


Trp Ile Val Ala Gly Gln Phe Ala Arg Ala Glu Arg Thr Ser Ser Gln 
            180                 185                 190         


Val Thr Ile Leu Cys Thr Phe Phe Thr Val Val Phe Ala Leu Tyr Leu 
        195                 200                 205             


Ala Pro Leu Thr Ile Ser Ser Pro Cys Ile Met Glu Lys Lys Asp Leu 
    210                 215                 220                 


Gly Pro Lys Pro Ala Leu Ile Gly His Arg Gly Ala Pro Met Leu Ala 
225                 230                 235                 240 


Pro Glu His Thr Leu Met Ser Phe Arg Lys Ala Leu Glu Gln Lys Leu 
                245                 250                 255     


Tyr Gly Leu Gln Ala Asp Ile Thr Ile Ser Leu Asp Gly Val Pro Phe 
            260                 265                 270         


Leu Met His Asp Thr Thr Leu Arg Arg Thr Thr Asn Val Glu Glu Glu 
        275                 280                 285             


Phe Pro Glu Leu Ala Arg Arg Pro Ala Ser Met Leu Asn Trp Thr Thr 
    290                 295                 300                 


Leu Gln Arg Leu Asn Ala Gly Gln Trp Phe Leu Lys Thr Asp Pro Phe 
305                 310                 315                 320 


Trp Thr Ala Ser Ser Leu Ser Pro Ser Asp His Arg Glu Ala Gln Asn 
                325                 330                 335     


Gln Ser Ile Cys Ser Leu Ala Glu Leu Leu Glu Leu Ala Lys Gly Asn 
            340                 345                 350         


Ala Thr Leu Leu Leu Asn Leu Arg Asp Pro Pro Arg Glu His Pro Tyr 
        355                 360                 365             


Arg Ser Ser Phe Ile Asn Val Thr Leu Glu Ala Val Leu His Ser Gly 
    370                 375                 380                 


Phe Pro Gln His Gln Val Met Trp Leu Pro Ser Arg Gln Arg Pro Leu 
385                 390                 395                 400 


Val Arg Lys Val Ala Pro Gly Phe Gln Gln Thr Ser Gly Ser Lys Glu 
                405                 410                 415     


Ala Val Ala Ser Leu Arg Arg Gly His Ile Gln Arg Leu Asn Leu Arg 
            420                 425                 430         


Tyr Thr Gln Val Ser Arg Gln Glu Leu Arg Asp Tyr Ala Ser Trp Asn 
        435                 440                 445             


Leu Ser Val Asn Leu Tyr Thr Val Asn Ala Pro Trp Leu Phe Ser Leu 
    450                 455                 460                 


Leu Trp Cys Ala Gly Val Pro Ser Val Thr Ser Asp Asn Ser His Ala 
465                 470                 475                 480 


Leu Ser Gln Val Pro Ser Pro Leu Trp Ile Met Pro Pro Asp Glu Tyr 
                485                 490                 495     


Cys Leu Met Trp Val Thr Ala Asp Leu Val Ser Phe Thr Leu Ile Val 
            500                 505                 510         


Gly Ile Phe Val Leu Gln Lys Trp Arg Leu Gly Gly Ile Arg Ser Tyr 
        515                 520                 525             


Asn Pro Glu Gln Ile Met Leu Ser Ala Ala Val Arg Arg Thr Ser Arg 
    530                 535                 540                 


Asp Val Ser Ile Met Lys Glu Lys Leu Ile Phe Ser Glu Ile Ser Asp 
545                 550                 555                 560 


Gly Val Glu Val Ser Asp Val Leu Ser Val Cys Ser Asp Asn Ser Tyr 
                565                 570                 575     


Asp Thr Tyr Ala Asn Ser Thr Ala Thr Pro Val Gly Pro Arg Gly Gly 
            580                 585                 590         


Gly Ser His Thr Lys Thr Leu Ile Glu Arg Ser Gly Arg 
        595                 600                 605 


<210>  5178
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  5178

Met Ser Gly Phe Glu Asn Leu Asn Thr Asp Phe Tyr Gln Thr Ser Tyr 
1               5                   10                  15      


Ser Ile Asp Asp Gln Ser Gln Gln Ser Tyr Asp Tyr Gly Gly Ser Gly 
            20                  25                  30          


Gly Pro Tyr Ser Lys Gln Tyr Ala Gly Tyr Asp Tyr Ser Gln Gln Gly 
        35                  40                  45              


Arg Phe Val Pro Pro Asp Met Met Gln Pro Gln Gln Pro Tyr Thr Gly 
    50                  55                  60                  


Gln Ile Tyr Gln Pro Thr Gln Ala Tyr Thr Pro Ala Ser Pro Gln Pro 
65                  70                  75                  80  


Phe Tyr Gly Asn Asn Phe Glu Asp Glu Pro Pro Leu Leu Glu Glu Leu 
                85                  90                  95      


Gly Ile Asn Phe Asp His Ile Trp Gln Lys Thr Leu Thr Val Leu His 
            100                 105                 110         


Pro Leu Lys Val Ala Asp Gly Ser Ile Met Asn Glu Thr Asp Leu Ala 
        115                 120                 125             


Gly Pro Met Val Phe Cys Leu Ala Phe Gly Ala Thr Leu Leu Leu Ala 
    130                 135                 140                 


Gly Lys Ile Gln Phe Gly Tyr Val Tyr Gly Ile Ser Ala Ile Gly Cys 
145                 150                 155                 160 


Leu Gly Met Phe Cys Leu Leu Asn Leu Met Ser Met Thr Gly Val Ser 
                165                 170                 175     


Phe Gly Cys Val Ala Ser Val Leu Gly Tyr Cys Leu Leu Pro Met Ile 
            180                 185                 190         


Leu Leu Ser Ser Phe Ala Val Ile Phe Ser Leu Gln Gly Met Val Gly 
        195                 200                 205             


Ile Ile Leu Thr Ala Gly Ile Ile Gly Trp Cys Ser Phe Ser Ala Ser 
    210                 215                 220                 


Lys Ile Phe Ile Ser Ala Leu Ala Met Glu Gly Gln Gln Leu Leu Val 
225                 230                 235                 240 


Ala Tyr Pro Cys Ala Leu Leu Tyr Gly Val Phe Ala Leu Ile Ser Val 
                245                 250                 255     


Phe 
    


<210>  5179
<211>  439
<212>  PRT
<213>  Homo sapiens

<400>  5179

Met Asp Asp Tyr Asp Lys Thr Cys Leu Glu Ser Ala Leu Val Gly Val 
1               5                   10                  15      


Cys Asn Ile Val Gln Gln Glu Trp Gly Gly Ala Ile Pro Cys Gln Val 
            20                  25                  30          


Val Leu Val Thr Asp Gly Cys Leu Gly Ile Gly Arg Gly Ser Leu Arg 
        35                  40                  45              


His Ser Leu Ala Thr Gln Asn Gln Arg Ser Glu Ser Asn Arg Phe Pro 
    50                  55                  60                  


Leu Pro Phe Pro Phe Pro Ser Lys Leu Tyr Ile Met Cys Met Ala Asn 
65                  70                  75                  80  


Leu Glu Glu Leu Gln Ser Thr Asp Ser Leu Glu Cys Leu Glu Arg Leu 
                85                  90                  95      


Ile Asp Leu Asn Asn Gly Glu Gly Gln Ile Phe Thr Ile Asp Gly Pro 
            100                 105                 110         


Leu Cys Leu Lys Asn Val Gln Ser Met Phe Gly Lys Leu Ile Asp Leu 
        115                 120                 125             


Ala Tyr Thr Pro Phe His Ala Val Leu Lys Cys Gly His Leu Thr Ala 
    130                 135                 140                 


Asp Val Gln Val Phe Pro Arg Pro Glu Pro Phe Val Val Asp Glu Glu 
145                 150                 155                 160 


Ile Asp Pro Ile Pro Lys Val Ile Asn Thr Asp Leu Glu Ile Val Gly 
                165                 170                 175     


Phe Ile Asp Ile Ala Asp Ile Ser Ser Pro Pro Val Leu Ser Arg His 
            180                 185                 190         


Leu Val Leu Pro Ile Ala Leu Asn Lys Glu Gly Asp Glu Val Gly Thr 
        195                 200                 205             


Gly Ile Thr Asp Asp Asn Glu Asp Glu Asn Ser Ala Asn Gln Ile Ala 
    210                 215                 220                 


Gly Lys Ile Pro Asn Phe Cys Val Leu Leu His Gly Ser Leu Lys Val 
225                 230                 235                 240 


Glu Gly Met Val Ala Ile Val Gln Leu Gly Pro Glu Trp His Gly Met 
                245                 250                 255     


Leu Tyr Ser Gln Ala Asp Ser Lys Lys Lys Ser Asn Leu Met Met Ser 
            260                 265                 270         


Leu Phe Glu Pro Gly Pro Glu Pro Leu Pro Trp Leu Gly Lys Met Ala 
        275                 280                 285             


Gln Leu Gly Pro Ile Ser Asp Ala Lys Glu Asn Pro Tyr Gly Glu Asp 
    290                 295                 300                 


Asp Asn Lys Ser Pro Phe Pro Leu Gln Pro Lys Asn Lys Arg Ser Tyr 
305                 310                 315                 320 


Ala Gln Asn Val Thr Val Trp Ile Lys Pro Ser Gly Leu Gln Thr Asp 
                325                 330                 335     


Val Gln Lys Ile Leu Arg Asn Ala Arg Lys Leu Pro Glu Lys Thr Gln 
            340                 345                 350         


Thr Phe Tyr Lys Glu Leu Asn Arg Leu Arg Lys Ala Ala Leu Ala Phe 
        355                 360                 365             


Gly Phe Leu Asp Leu Leu Lys Gly Val Ala Asp Met Leu Glu Arg Glu 
    370                 375                 380                 


Cys Thr Leu Leu Pro Glu Thr Ala His Pro Asp Ala Ala Phe Gln Leu 
385                 390                 395                 400 


Thr His Ala Ala Gln Gln Leu Lys Leu Ala Ser Thr Gly Thr Ser Glu 
                405                 410                 415     


Tyr Ala Ala Tyr Asp Gln Asn Ile Thr Pro Leu His Thr Asp Phe Ser 
            420                 425                 430         


Gly Ser Ser Thr Glu Arg Ile 
        435                 


<210>  5180
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  5180

Met Ala Ala Thr Leu Gly Pro Leu Gly Ser Trp Gln Gln Trp Arg Arg 
1               5                   10                  15      


Cys Leu Ser Ala Arg Asp Gly Ser Arg Met Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Gly Ser Gly Gln Gly Pro Gln Gln Val Gly Ala Gly Gln Thr Phe 
        35                  40                  45              


Glu Tyr Leu Lys Arg Glu His Ser Leu Ser Lys Pro Tyr Gln Gly Val 
    50                  55                  60                  


Gly Thr Gly Ser Ser Ser Leu Trp Asn Leu Met Gly Asn Ala Met Val 
65                  70                  75                  80  


Met Thr Gln Tyr Ile Arg Leu Thr Pro Asp Met Gln Ser Lys Gln Gly 
                85                  90                  95      


Ala Leu Trp Asn Arg Val Pro Cys Phe Leu Arg Asp Trp Glu Leu Gln 
            100                 105                 110         


Val His Phe Lys Ile His Gly Gln Gly Lys Lys Asn Leu His Gly Asp 
        115                 120                 125             


Gly Leu Ala Ile Trp Tyr Thr Lys Asp Arg Met Gln Pro Gly Pro Val 
    130                 135                 140                 


Phe Gly Asn Met Asp Lys Phe Val Gly Leu Gly Val Phe Val Asp Thr 
145                 150                 155                 160 


Tyr Pro Asn Glu Glu Lys Gln Gln Glu Arg Val Phe Pro Tyr Ile Ser 
                165                 170                 175     


Ala Met Val Asn Asn Gly Ser Leu Ser Tyr Asp His Glu Arg Asp Gly 
            180                 185                 190         


Arg Pro Thr Glu Leu Gly Gly Cys Thr Ala Ile Val Arg Asn Leu His 
        195                 200                 205             


Tyr Asp Thr Phe Leu Val Ile Arg Tyr Val Lys Arg His Leu Thr Ile 
    210                 215                 220                 


Met Met Asp Ile Asp Gly Lys His Glu Trp Arg Asp Cys Ile Glu Val 
225                 230                 235                 240 


Pro Gly Val Arg Leu Pro Arg Gly Tyr Tyr Phe Gly Thr Ser Ser Ile 
                245                 250                 255     


Thr Gly Asp Leu Ser Asp Asn His Asp Val Ile Ser Leu Lys Leu Phe 
            260                 265                 270         


Glu Leu Thr Val Glu Arg Thr Pro Glu Glu Glu Lys Leu His Arg Asp 
        275                 280                 285             


Val Phe Leu Pro Ser Val Asp Asn Met Lys Leu Pro Glu Met Thr Ala 
    290                 295                 300                 


Pro Leu Pro Pro Leu Ser Gly Leu Ala Leu Phe Leu Ile Val Phe Phe 
305                 310                 315                 320 


Ser Leu Val Phe Ser Val Phe Ala Ile Val Ile Gly Ile Ile Leu Tyr 
                325                 330                 335     


Asn Lys Trp Gln Glu Gln Ser Arg Lys Arg Phe Tyr 
            340                 345             


<210>  5181
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  5181

Met Gly Met Glu Arg Pro Ala Ala Arg Glu Pro His Gly Pro Asp Ala 
1               5                   10                  15      


Leu Arg Arg Phe Gln Gly Leu Leu Leu Asp Arg Arg Gly Arg Leu His 
            20                  25                  30          


Gly Gln Val Leu Arg Leu Arg Glu Val Ala Arg Arg Leu Glu Arg Leu 
        35                  40                  45              


Arg Arg Arg Ser Leu Val Ala Asn Val Ala Gly Ser Ser Leu Ser Ala 
    50                  55                  60                  


Thr Gly Ala Leu Ala Ala Ile Val Gly Leu Ser Leu Ser Pro Val Thr 
65                  70                  75                  80  


Leu Gly Thr Ser Leu Leu Val Ser Ala Val Gly Leu Gly Val Ala Thr 
                85                  90                  95      


Ala Gly Gly Ala Val Thr Ile Thr Ser Asp Leu Ser Leu Ile Phe Cys 
            100                 105                 110         


Asn Ser Arg Glu Leu Arg Arg Val Gln Glu Ile Ala Ala Thr Cys Gln 
        115                 120                 125             


Asp Gln Met Arg Glu Ile Leu Ser Cys Leu Glu Phe Phe Cys Arg Trp 
    130                 135                 140                 


Gln Gly Cys Gly Asp Arg Gln Leu Leu Gln Cys Gly Arg Asn Ala Ser 
145                 150                 155                 160 


Ile Ala Leu Tyr Asn Ser Val Tyr Phe Ile Val Phe Phe Gly Ser Arg 
                165                 170                 175     


Gly Phe Leu Ile Pro Arg Arg Ala Glu Gly Asp Thr Lys Val Ser Gln 
            180                 185                 190         


Ala Val Leu Lys Ala Lys Ile Gln Lys Leu Ala Glu Ser Leu Glu Ser 
        195                 200                 205             


Cys Thr Gly Ala Leu Asp Glu Leu Ser Glu Gln Leu Glu Ser Arg Val 
    210                 215                 220                 


Gln Leu Cys Thr Lys Ser Ser Arg Gly His Asp Leu Lys Ile Ser Ala 
225                 230                 235                 240 


Asp Gln Arg Ala Gly Leu Phe Phe 
                245             


<210>  5182
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  5182

Met Glu Asn Val Thr Thr Met Asn Glu Phe Leu Leu Leu Gly Leu Thr 
1               5                   10                  15      


Gly Val Gln Glu Leu Gln Pro Phe Phe Phe Gly Ile Phe Leu Ile Ile 
            20                  25                  30          


Tyr Leu Ile Asn Leu Ile Gly Asn Gly Ser Ile Leu Val Met Val Val 
        35                  40                  45              


Leu Glu Pro Gln Leu His Ser Pro Met Tyr Phe Phe Leu Gly Asn Leu 
    50                  55                  60                  


Ser Cys Leu Asp Ile Ser Tyr Ser Ser Val Thr Leu Pro Lys Leu Leu 
65                  70                  75                  80  


Val Asn Leu Val Cys Ser Arg Arg Ala Ile Ser Phe Leu Gly Cys Ile 
                85                  90                  95      


Thr Gln Leu His Phe Phe His Phe Leu Gly Ser Thr Glu Ala Ile Leu 
            100                 105                 110         


Leu Ala Ile Met Ala Phe Asp Arg Phe Val Ala Ile Cys Asn Pro Leu 
        115                 120                 125             


Arg Tyr Thr Val Ile Met Asn Pro Gln Val Cys Ile Leu Leu Ala Ala 
    130                 135                 140                 


Ala Ala Trp Leu Ile Ser Phe Phe Tyr Ala Leu Met His Ser Val Met 
145                 150                 155                 160 


Thr Ala His Leu Ser Phe Cys Gly Ser Gln Lys Leu Asn His Phe Phe 
                165                 170                 175     


Tyr Asp Val Lys Pro Leu Leu Glu Leu Ala Cys Ser Asp Thr Leu Leu 
            180                 185                 190         


Asn Gln Trp Leu Leu Ser Ile Val Thr Gly Ser Ile Ser Met Gly Ala 
        195                 200                 205             


Phe Phe Leu Thr Leu Leu Ser Cys Phe Tyr Val Ile Gly Phe Leu Leu 
    210                 215                 220                 


Phe Lys Asn Arg Ser Cys Arg Ile Leu His Lys Ala Leu Ser Thr Cys 
225                 230                 235                 240 


Ala Ser His Phe Met Val Val Cys Leu Phe Tyr Gly Pro Val Gly Phe 
                245                 250                 255     


Thr Tyr Ile Arg Pro Ala Ser Ala Thr Ser Met Ile Gln Asp Arg Ile 
            260                 265                 270         


Met Ala Ile Met Tyr Ser Ala Val Thr Pro Val Leu Asn Pro Leu Ile 
        275                 280                 285             


Tyr Thr Leu Arg Asn Lys Glu Val Met Met Ala Leu Lys Lys Ile Phe 
    290                 295                 300                 


Gly Arg Lys Leu Phe Lys Asp Trp Gln Gln His His 
305                 310                 315     


<210>  5183
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  5183

Met Glu Arg Lys Asn Gln Thr Ala Ile Thr Glu Phe Ile Ile Leu Gly 
1               5                   10                  15      


Phe Ser Asn Leu Asn Glu Leu Gln Phe Leu Leu Phe Thr Ile Phe Phe 
            20                  25                  30          


Leu Thr Tyr Phe Cys Thr Leu Gly Gly Asn Ile Leu Ile Ile Leu Thr 
        35                  40                  45              


Thr Val Thr Asp Pro His Leu His Thr Pro Met Tyr Tyr Phe Leu Gly 
    50                  55                  60                  


Asn Leu Ala Phe Ile Asp Ile Cys Tyr Thr Thr Ser Asn Val Pro Gln 
65                  70                  75                  80  


Met Met Val His Leu Leu Ser Lys Lys Lys Ser Ile Ser Tyr Val Gly 
                85                  90                  95      


Cys Val Val Gln Leu Phe Ala Phe Val Phe Phe Val Gly Ser Glu Cys 
            100                 105                 110         


Leu Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ile Ala Ile Cys Asn 
        115                 120                 125             


Pro Leu Arg Tyr Ser Val Ile Leu Ser Lys Val Leu Cys Asn Gln Leu 
    130                 135                 140                 


Ala Ala Ser Cys Trp Ala Ala Gly Phe Leu Asn Ser Val Val His Thr 
145                 150                 155                 160 


Val Leu Thr Phe Cys Leu Pro Phe Cys Gly Asn Asn Gln Ile Asn Tyr 
                165                 170                 175     


Phe Phe Cys Asp Ile Pro Pro Leu Leu Ile Leu Ser Cys Gly Asn Thr 
            180                 185                 190         


Ser Val Asn Glu Leu Ala Leu Leu Ser Thr Gly Val Phe Ile Gly Trp 
        195                 200                 205             


Thr Pro Phe Leu Cys Ile Val Leu Ser Tyr Ile Cys Ile Ile Ser Thr 
    210                 215                 220                 


Ile Leu Arg Ile Gln Ser Ser Glu Gly Arg Arg Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Ala Ser His Leu Ala Ile Val Phe Leu Phe Tyr Gly Ser Ala Ile 
                245                 250                 255     


Phe Thr Tyr Val Arg Pro Ile Ser Thr Tyr Ser Leu Lys Lys Asp Arg 
            260                 265                 270         


Leu Val Ser Val Leu Tyr Ser Val Val Thr Pro Met Leu Asn Pro Ile 
        275                 280                 285             


Ile Tyr Thr Leu Arg Asn Lys Asp Ile Lys Glu Ala Val Lys Thr Ile 
    290                 295                 300                 


Gly Ser Lys Trp Gln Pro Pro Ile Ser Ser Leu Asp Ser Lys Leu Thr 
305                 310                 315                 320 


Tyr 
    


<210>  5184
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  5184

Met Asn Pro Glu Ser Ser Ile Phe Ile Glu Asp Tyr Leu Lys Tyr Phe 
1               5                   10                  15      


Gln Asp Gln Val Ser Arg Glu Asn Leu Leu Gln Leu Leu Thr Asp Asp 
            20                  25                  30          


Glu Ala Trp Asn Gly Phe Val Ala Ala Ala Glu Leu Pro Arg Asp Glu 
        35                  40                  45              


Ala Asp Glu Leu Arg Lys Ala Leu Asn Lys Leu Ala Ser His Met Val 
    50                  55                  60                  


Met Lys Asp Lys Asn Arg His Asp Lys Asp Gln Gln His Arg Gln Trp 
65                  70                  75                  80  


Phe Leu Lys Glu Phe Pro Arg Leu Lys Arg Glu Leu Glu Asp His Ile 
                85                  90                  95      


Arg Lys Leu Arg Ala Leu Ala Glu Glu Val Glu Gln Val His Arg Gly 
            100                 105                 110         


Thr Thr Ile Ala Asn Val Val Ser Asn Ser Val Gly Thr Thr Ser Gly 
        115                 120                 125             


Ile Leu Thr Leu Leu Gly Leu Gly Leu Ala Pro Phe Thr Glu Gly Ile 
    130                 135                 140                 


Ser Phe Val Leu Leu Asp Thr Gly Met Gly Leu Gly Ala Ala Ala Ala 
145                 150                 155                 160 


Val Ala Gly Ile Thr Cys Ser Val Val Glu Leu Val Asn Lys Leu Arg 
                165                 170                 175     


Ala Arg Ala Gln Ala Arg Asn Leu Asp Gln Ser Gly Thr Asn Val Ala 
            180                 185                 190         


Lys Val Met Lys Glu Phe Val Gly Gly Asn Thr Pro Asn Val Leu Thr 
        195                 200                 205             


Leu Val Asp Asn Trp Tyr Gln Val Thr Gln Gly Ile Gly Arg Asn Ile 
    210                 215                 220                 


Arg Ala Ile Arg Arg Ala Arg Ala Asn Pro Gln Leu Gly Ala Tyr Ala 
225                 230                 235                 240 


Pro Pro Pro His Val Ile Gly Arg Ile Ser Ala Glu Gly Gly Glu Gln 
                245                 250                 255     


Val Glu Arg Val Val Glu Gly Pro Ala Gln Ala Met Ser Arg Gly Thr 
            260                 265                 270         


Met Ile Val Gly Ala Ala Thr Gly Gly Ile Leu Leu Leu Leu Asp Val 
        275                 280                 285             


Val Ser Leu Ala Tyr Glu Ser Lys His Leu Leu Glu Gly Ala Lys Ser 
    290                 295                 300                 


Glu Ser Ala Glu Glu Leu Lys Lys Arg Ala Gln Glu Leu Glu Gly Lys 
305                 310                 315                 320 


Leu Asn Phe Leu Thr Lys Ile His Glu Met Leu Gln Pro Gly Gln Asp 
                325                 330                 335     


Gln 
    


<210>  5185
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  5185

Met Val Asn Gln Ser Ser Pro Met Gly Phe Leu Leu Leu Gly Phe Ser 
1               5                   10                  15      


Glu His Pro Ala Leu Glu Arg Thr Leu Phe Val Val Val Phe Thr Ser 
            20                  25                  30          


Tyr Leu Leu Thr Leu Val Gly Asn Thr Leu Ile Ile Leu Leu Ser Val 
        35                  40                  45              


Leu Tyr Pro Arg Leu His Ser Pro Met Tyr Phe Phe Leu Ser Asp Leu 
    50                  55                  60                  


Ser Phe Leu Asp Leu Cys Phe Thr Thr Ser Cys Val Pro Gln Met Leu 
65                  70                  75                  80  


Val Asn Leu Trp Gly Pro Lys Lys Thr Ile Ser Phe Leu Gly Cys Ser 
                85                  90                  95      


Val Gln Leu Phe Ile Phe Leu Ser Leu Gly Thr Thr Glu Cys Ile Leu 
            100                 105                 110         


Leu Thr Val Met Ala Phe Asp Arg Tyr Val Ala Val Cys Gln Pro Leu 
        115                 120                 125             


His Tyr Ala Thr Ile Ile His Pro Arg Leu Cys Trp Gln Leu Ala Ser 
    130                 135                 140                 


Val Ala Trp Val Met Ser Leu Val Gln Ser Ile Val Gln Thr Pro Ser 
145                 150                 155                 160 


Thr Leu His Leu Pro Phe Cys Pro His Gln Gln Ile Asp Asp Phe Leu 
                165                 170                 175     


Cys Glu Val Pro Ser Leu Ile Arg Leu Ser Cys Gly Asp Thr Ser Tyr 
            180                 185                 190         


Asn Glu Ile Gln Leu Ala Val Ser Ser Val Ile Phe Val Val Val Pro 
        195                 200                 205             


Leu Ser Leu Ile Leu Ala Ser Tyr Gly Ala Thr Ala Gln Ala Val Leu 
    210                 215                 220                 


Arg Ile Asn Ser Ala Thr Ala Trp Arg Lys Ala Phe Gly Thr Cys Ser 
225                 230                 235                 240 


Ser His Leu Thr Val Val Thr Leu Phe Tyr Ser Ser Val Ile Ala Val 
                245                 250                 255     


Tyr Leu Gln Pro Lys Asn Pro Tyr Ala Gln Gly Arg Gly Lys Phe Phe 
            260                 265                 270         


Gly Leu Phe Tyr Ala Val Gly Thr Pro Ser Leu Asn Pro Leu Val Tyr 
        275                 280                 285             


Thr Leu Arg Asn Lys Glu Ile Lys Arg Ala Leu Arg Arg Leu Leu Gly 
    290                 295                 300                 


Lys Glu Arg Asp Ser Arg Glu Ser Trp Arg Ala Ala 
305                 310                 315     


<210>  5186
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  5186

Met Gly Thr Val Arg Pro Pro Arg Pro Ser Leu Leu Leu Val Ser Thr 
1               5                   10                  15      


Arg Glu Ser Cys Leu Phe Leu Leu Phe Cys Leu His Leu Gly Ala Ala 
            20                  25                  30          


Cys Pro Gln Pro Cys Arg Cys Pro Asp His Ala Gly Ala Val Ala Val 
        35                  40                  45              


Phe Cys Ser Leu Arg Gly Leu Gln Glu Val Pro Glu Asp Ile Pro Ala 
    50                  55                  60                  


Asn Thr Val Leu Leu Lys Leu Asp Ala Asn Lys Ile Ser His Leu Pro 
65                  70                  75                  80  


Asp Gly Ala Phe Gln His Leu His Arg Leu Arg Glu Leu Asp Leu Ser 
                85                  90                  95      


His Asn Ala Ile Glu Ala Ile Gly Ser Ala Thr Phe Ala Gly Leu Ala 
            100                 105                 110         


Gly Gly Leu Arg Leu Leu Asp Leu Ser Tyr Asn Arg Ile Gln Arg Ile 
        115                 120                 125             


Pro Lys Asp Ala Leu Gly Lys Leu Ser Ala Lys Ile Arg Leu Ser His 
    130                 135                 140                 


Asn Pro Leu His Cys Glu Cys Ala Leu Gln Glu Ala Leu Trp Glu Leu 
145                 150                 155                 160 


Lys Leu Asp Pro Asp Ser Val Asp Glu Ile Ala Cys His Thr Ser Val 
                165                 170                 175     


Gln Glu Glu Phe Val Gly Lys Pro Leu Val Gln Ala Leu Asp Ala Gly 
            180                 185                 190         


Ala Ser Leu Cys Ser Val Pro His Arg Thr Thr Asp Val Ala Met Leu 
        195                 200                 205             


Val Thr Met Phe Gly Trp Phe Ala Met Val Ile Ala Tyr Val Val Tyr 
    210                 215                 220                 


Tyr Val Arg His Asn Gln Glu Asp Ala Arg Arg His Leu Glu Tyr Leu 
225                 230                 235                 240 


Lys Ser Leu Pro Ser Ala Pro Ala Ser Lys Asp Pro Ile Gly Pro Gly 
                245                 250                 255     


Pro 
    


<210>  5187
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  5187

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Ala Pro Gln Ala Leu Gln Ser Tyr His Leu Ala Ala Glu 
            20                  25                  30          


Glu Gln Leu Ser Phe Arg Met Leu Gln Thr Ser Ser Phe Ala Asn His 
        35                  40                  45              


Ser Trp Ala His Ser Glu Gly Ser Gly Trp Leu Gly Asp Leu Gln Thr 
    50                  55                  60                  


His Gly Trp Asp Thr Val Leu Gly Thr Ile Arg Phe Leu Lys Pro Trp 
65                  70                  75                  80  


Ser His Gly Asn Phe Ser Lys Gln Glu Leu Lys Asn Leu Gln Ser Leu 
                85                  90                  95      


Phe Gln Leu Tyr Phe His Ser Phe Ile Gln Ile Val Gln Ala Ser Ala 
            100                 105                 110         


Gly Gln Phe Gln Leu Glu Tyr Pro Phe Glu Ile Gln Ile Leu Ala Gly 
        115                 120                 125             


Cys Arg Met Asn Ala Pro Gln Ile Phe Leu Asn Met Ala Tyr Gln Gly 
    130                 135                 140                 


Ser Asp Phe Leu Ser Phe Gln Gly Ile Ser Trp Glu Pro Ser Pro Gly 
145                 150                 155                 160 


Ala Gly Ile Arg Ala Gln Asn Ile Cys Lys Val Leu Asn Arg Tyr Leu 
                165                 170                 175     


Asp Ile Lys Glu Ile Leu Gln Ser Leu Leu Gly His Thr Cys Pro Arg 
            180                 185                 190         


Phe Leu Ala Gly Leu Met Glu Ala Gly Glu Ser Glu Leu Lys Arg Lys 
        195                 200                 205             


Val Lys Pro Glu Ala Trp Leu Ser Cys Gly Pro Ser Pro Gly Pro Gly 
    210                 215                 220                 


Arg Leu Gln Leu Val Cys His Val Ser Gly Phe Tyr Pro Lys Pro Val 
225                 230                 235                 240 


Trp Val Met Trp Met Arg Gly Glu Gln Glu Gln Arg Gly Thr Gln Arg 
                245                 250                 255     


Gly Asp Val Leu Pro Asn Ala Asp Glu Thr Trp Tyr Leu Arg Ala Thr 
            260                 265                 270         


Leu Asp Val Ala Ala Gly Glu Ala Ala Gly Leu Ser Cys Arg Val Lys 
        275                 280                 285             


His Ser Ser Leu Gly Gly His Asp Leu Ile Ile His Trp Gly Gly Tyr 
    290                 295                 300                 


Ser Ile Phe Leu Ile Leu Ile Cys Leu Thr Val Ile Val Thr Leu Val 
305                 310                 315                 320 


Ile Leu Val Val Val Asp Ser Arg Leu Lys Lys Gln Ser Ser Asn Lys 
                325                 330                 335     


Asn Ile Leu Ser Pro His Thr Pro Ser Pro Val Phe Leu Met Gly Ala 
            340                 345                 350         


Asn Thr Gln Asp Thr Lys Asn Ser Arg His Gln Phe Cys Leu Ala Gln 
        355                 360                 365             


Val Ser Trp Ile Lys Asn Arg Val Leu Lys Lys Trp Lys Thr Arg Leu 
    370                 375                 380                 


Asn Gln Leu Trp 
385             


<210>  5188
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  5188

Met Glu Pro Glu Asn Asp Thr Gly Ile Ser Glu Phe Val Leu Leu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Pro Glu Leu Gln Pro Phe Leu Phe Gly Leu Phe Leu 
            20                  25                  30          


Ser Met Tyr Leu Val Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Ala 
        35                  40                  45              


Thr Ile Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 
    50                  55                  60                  


Asn Leu Ser Phe Ala Asp Ile Cys Phe Ile Ser Thr Thr Ile Pro Lys 
65                  70                  75                  80  


Met Leu Ile Asn Ile Gln Thr Gln Ser Arg Val Ile Thr Tyr Ala Gly 
                85                  90                  95      


Cys Ile Thr Gln Met Cys Phe Phe Val Leu Phe Gly Gly Leu Asp Ser 
            100                 105                 110         


Leu Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 
        115                 120                 125             


Pro Leu His Tyr Thr Val Ile Met Asn Pro Arg Leu Cys Gly Leu Leu 
    130                 135                 140                 


Val Leu Ala Ser Trp Met Ile Ala Ala Leu Asn Ser Leu Ser Gln Ser 
145                 150                 155                 160 


Leu Met Val Leu Trp Leu Ser Phe Cys Thr Asp Leu Glu Ile Pro His 
                165                 170                 175     


Phe Phe Cys Glu Leu Asn Gln Val Ile His Leu Ala Cys Ser Asp Thr 
            180                 185                 190         


Phe Leu Asn Asp Met Gly Met Tyr Phe Ala Ala Gly Leu Leu Ala Gly 
        195                 200                 205             


Gly Pro Leu Val Gly Ile Leu Cys Ser Tyr Ser Lys Ile Val Ser Ser 
    210                 215                 220                 


Ile Arg Ala Ile Ser Ser Ala Gln Gly Lys Tyr Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Cys Cys Thr Gly Leu 
                245                 250                 255     


Gly Val Tyr Leu Thr Ser Ala Ala Thr His Asn Ser His Thr Ser Ala 
            260                 265                 270         


Thr Ala Ser Val Met Tyr Thr Val Ala Thr Pro Met Leu Asn Pro Phe 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Arg Ala Leu Lys Met Ser 
    290                 295                 300                 


Phe Arg Gly Lys Gln 
305                 


<210>  5189
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  5189

Met Asp Gln Ser Asn Tyr Ser Ser Leu His Gly Phe Ile Leu Leu Gly 
1               5                   10                  15      


Phe Ser Asn His Pro Lys Met Glu Met Ile Leu Ser Gly Val Val Ala 
            20                  25                  30          


Ile Phe Tyr Leu Ile Thr Leu Val Gly Asn Thr Ala Ile Ile Leu Ala 
        35                  40                  45              


Ser Leu Leu Asp Ser Gln Leu His Thr Pro Met Tyr Phe Phe Leu Arg 
    50                  55                  60                  


Asn Leu Ser Phe Leu Asp Leu Cys Phe Thr Thr Ser Ile Ile Pro Gln 
65                  70                  75                  80  


Met Leu Val Asn Leu Trp Gly Pro Asp Lys Thr Ile Ser Tyr Val Gly 
                85                  90                  95      


Cys Ile Ile Gln Leu Tyr Val Tyr Met Trp Leu Gly Ser Val Glu Cys 
            100                 105                 110         


Leu Leu Leu Ala Val Met Ser Tyr Asp Arg Phe Thr Ala Ile Cys Lys 
        115                 120                 125             


Pro Leu His Tyr Phe Val Val Met Asn Pro His Leu Cys Leu Lys Met 
    130                 135                 140                 


Ile Ile Met Ile Trp Ser Ile Ser Leu Ala Asn Ser Val Val Leu Cys 
145                 150                 155                 160 


Thr Leu Thr Leu Asn Leu Pro Thr Cys Gly Asn Asn Ile Leu Asp His 
                165                 170                 175     


Phe Leu Cys Glu Leu Pro Ala Leu Val Lys Ile Ala Cys Val Asp Thr 
            180                 185                 190         


Thr Thr Val Glu Met Ser Val Phe Ala Leu Gly Ile Ile Ile Val Leu 
        195                 200                 205             


Thr Pro Leu Ile Leu Ile Leu Ile Ser Tyr Gly Tyr Ile Ala Lys Ala 
    210                 215                 220                 


Val Leu Arg Thr Lys Ser Lys Ala Ser Gln Arg Lys Ala Met Asn Thr 
225                 230                 235                 240 


Cys Gly Ser His Leu Thr Val Val Ser Met Phe Tyr Gly Thr Ile Ile 
                245                 250                 255     


Tyr Met Tyr Leu Gln Pro Gly Asn Arg Ala Ser Lys Asp Gln Gly Lys 
            260                 265                 270         


Phe Leu Thr Leu Phe Tyr Thr Val Ile Thr Pro Ser Leu Asn Pro Leu 
        275                 280                 285             


Ile Tyr Thr Leu Arg Asn Lys Asp Met Lys Asp Ala Leu Lys Lys Leu 
    290                 295                 300                 


Met Arg Phe His His Lys Ser Thr Lys Ile Lys Arg Asn Cys Lys Ser 
305                 310                 315                 320 


<210>  5190
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  5190

Met Met Ile Lys Lys Asn Ala Ser Ser Glu Asp Phe Phe Ile Leu Leu 
1               5                   10                  15      


Gly Phe Ser Asn Trp Pro Gln Leu Glu Val Val Leu Phe Val Val Ile 
            20                  25                  30          


Leu Ile Phe Tyr Leu Met Thr Leu Thr Gly Asn Leu Phe Ile Ile Ile 
        35                  40                  45              


Leu Ser Tyr Val Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu 
    50                  55                  60                  


Ser Asn Leu Ser Phe Leu Asp Leu Cys Tyr Thr Thr Ser Ser Ile Pro 
65                  70                  75                  80  


Gln Leu Leu Val Asn Leu Arg Gly Pro Glu Lys Thr Ile Ser Tyr Ala 
                85                  90                  95      


Gly Cys Met Val Gln Leu Tyr Phe Val Leu Ala Leu Gly Ile Thr Glu 
            100                 105                 110         


Cys Val Leu Leu Val Val Met Ser Tyr Asp Arg Tyr Val Ala Val Cys 
        115                 120                 125             


Arg Pro Leu His Tyr Thr Val Leu Met His Pro Arg Phe Cys His Leu 
    130                 135                 140                 


Leu Val Ala Ala Ser Trp Val Ile Gly Phe Thr Ile Ser Ala Leu His 
145                 150                 155                 160 


Ser Ser Phe Thr Phe Trp Val Pro Leu Cys Gly His Arg Leu Val Asp 
                165                 170                 175     


His Phe Phe Cys Glu Val Pro Ala Leu Leu Arg Leu Ser Cys Val Asp 
            180                 185                 190         


Thr His Ala Asn Glu Leu Thr Leu Met Val Met Ser Ser Ile Phe Val 
        195                 200                 205             


Leu Ile Pro Leu Ile Leu Ile Leu Thr Thr Tyr Gly Ala Ile Ala Arg 
    210                 215                 220                 


Ala Val Leu Ser Met Gln Ser Thr Thr Gly Leu Gln Lys Val Phe Arg 
225                 230                 235                 240 


Thr Cys Gly Ala His Leu Met Val Val Ser Leu Phe Phe Ile Pro Val 
                245                 250                 255     


Met Cys Met Tyr Leu Gln Pro Pro Ser Glu Asn Ser Pro Asp Gln Gly 
            260                 265                 270         


Lys Phe Ile Ala Leu Phe Tyr Thr Val Val Thr Pro Ser Leu Asn Pro 
        275                 280                 285             


Leu Ile Tyr Thr Leu Arg Asn Lys His Val Lys Gly Ala Ala Lys Arg 
    290                 295                 300                 


Leu Leu Gly Trp Glu Trp Gly Lys 
305                 310         


<210>  5191
<211>  510
<212>  PRT
<213>  Homo sapiens

<400>  5191

Met Pro Leu Ser Leu Gly Ala Glu Met Trp Gly Pro Glu Ala Trp Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ala Ser Phe Thr Gly Arg Cys Pro Ala Gly 
            20                  25                  30          


Glu Leu Glu Thr Ser Asp Val Val Thr Val Val Leu Gly Gln Asp Ala 
        35                  40                  45              


Lys Leu Pro Cys Phe Tyr Arg Gly Asp Ser Gly Glu Gln Val Gly Gln 
    50                  55                  60                  


Val Ala Trp Ala Arg Val Asp Ala Gly Glu Gly Ala Gln Glu Leu Ala 
65                  70                  75                  80  


Leu Leu His Ser Lys Tyr Gly Leu His Val Ser Pro Ala Tyr Glu Gly 
                85                  90                  95      


Arg Val Glu Gln Pro Pro Pro Pro Arg Asn Pro Leu Asp Gly Ser Val 
            100                 105                 110         


Leu Leu Arg Asn Ala Val Gln Ala Asp Glu Gly Glu Tyr Glu Cys Arg 
        115                 120                 125             


Val Ser Thr Phe Pro Ala Gly Ser Phe Gln Ala Arg Leu Arg Leu Arg 
    130                 135                 140                 


Val Leu Val Pro Pro Leu Pro Ser Leu Asn Pro Gly Pro Ala Leu Glu 
145                 150                 155                 160 


Glu Gly Gln Gly Leu Thr Leu Ala Ala Ser Cys Thr Ala Glu Gly Ser 
                165                 170                 175     


Pro Ala Pro Ser Val Thr Trp Asp Thr Glu Val Lys Gly Thr Thr Ser 
            180                 185                 190         


Ser Arg Ser Phe Lys His Ser Arg Ser Ala Ala Val Thr Ser Glu Phe 
        195                 200                 205             


His Leu Val Pro Ser Arg Ser Met Asn Gly Gln Pro Leu Thr Cys Val 
    210                 215                 220                 


Val Ser His Pro Gly Leu Leu Gln Asp Gln Arg Ile Thr His Ile Leu 
225                 230                 235                 240 


His Val Ser Phe Leu Ala Glu Ala Ser Val Arg Gly Leu Glu Asp Gln 
                245                 250                 255     


Asn Leu Trp His Ile Gly Arg Glu Gly Ala Met Leu Lys Cys Leu Ser 
            260                 265                 270         


Glu Gly Gln Pro Pro Pro Ser Tyr Asn Trp Thr Arg Leu Asp Gly Pro 
        275                 280                 285             


Leu Pro Ser Gly Val Arg Val Asp Gly Asp Thr Leu Gly Phe Pro Pro 
    290                 295                 300                 


Leu Thr Thr Glu His Ser Gly Ile Tyr Val Cys His Val Ser Asn Glu 
305                 310                 315                 320 


Phe Ser Ser Arg Asp Ser Gln Val Thr Val Asp Val Leu Asp Pro Gln 
                325                 330                 335     


Glu Asp Ser Gly Lys Gln Val Asp Leu Val Ser Ala Ser Val Val Val 
            340                 345                 350         


Val Gly Val Ile Ala Ala Leu Leu Phe Cys Leu Leu Val Val Val Val 
        355                 360                 365             


Val Leu Met Ser Arg Tyr His Arg Arg Lys Ala Gln Gln Met Thr Gln 
    370                 375                 380                 


Lys Tyr Glu Glu Glu Leu Thr Leu Thr Arg Glu Asn Ser Ile Arg Arg 
385                 390                 395                 400 


Leu His Ser His His Thr Asp Pro Arg Ser Gln Pro Glu Glu Ser Val 
                405                 410                 415     


Gly Leu Arg Ala Glu Gly His Pro Asp Ser Leu Lys Asp Asn Ser Ser 
            420                 425                 430         


Cys Ser Val Met Ser Glu Glu Pro Glu Gly Arg Ser Tyr Ser Thr Leu 
        435                 440                 445             


Thr Thr Val Arg Glu Ile Glu Thr Gln Thr Glu Leu Leu Ser Pro Gly 
    450                 455                 460                 


Ser Gly Arg Ala Glu Glu Glu Glu Asp Gln Asp Glu Gly Ile Lys Gln 
465                 470                 475                 480 


Ala Met Asn His Phe Val Gln Glu Asn Gly Thr Leu Arg Ala Lys Pro 
                485                 490                 495     


Thr Gly Asn Gly Ile Tyr Ile Asn Gly Arg Gly His Leu Val 
            500                 505                 510 


<210>  5192
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  5192

Met Ser Gln Gly Arg Gly Lys Tyr Asp Phe Tyr Ile Gly Leu Gly Leu 
1               5                   10                  15      


Ala Met Ser Ser Ser Ile Phe Ile Gly Gly Ser Phe Ile Leu Lys Lys 
            20                  25                  30          


Lys Gly Leu Leu Arg Leu Ala Arg Lys Gly Ser Met Arg Ala Gly Gln 
        35                  40                  45              


Gly Gly His Ala Tyr Leu Lys Glu Trp Leu Trp Trp Ala Gly Leu Leu 
    50                  55                  60                  


Ser Met Gly Ala Gly Glu Val Ala Asn Phe Ala Ala Tyr Ala Phe Ala 
65                  70                  75                  80  


Pro Ala Thr Leu Val Thr Pro Leu Gly Ala Leu Ser Val Leu Val Ser 
                85                  90                  95      


Ala Ile Leu Ser Ser Tyr Phe Leu Asn Glu Arg Leu Asn Leu His Gly 
            100                 105                 110         


Lys Ile Gly Cys Leu Leu Ser Ile Leu Gly Ser Thr Val Met Val Ile 
        115                 120                 125             


His Ala Pro Lys Glu Glu Glu Ile Glu Thr Leu Asn Glu Met Ser His 
    130                 135                 140                 


Lys Leu Gly Asp Pro Gly Phe Val Val Phe Ala Thr Leu Val Val Ile 
145                 150                 155                 160 


Val Ala Leu Ile Leu Ile Phe Val Val Gly Pro Arg His Gly Gln Thr 
                165                 170                 175     


Asn Ile Leu Val Tyr Ile Thr Ile Cys Ser Val Ile Gly Ala Phe Ser 
            180                 185                 190         


Val Ser Cys Val Lys Gly Leu Gly Ile Ala Ile Lys Glu Leu Phe Ala 
        195                 200                 205             


Gly Lys Pro Val Leu Arg His Pro Leu Ala Trp Ile Leu Leu Leu Ser 
    210                 215                 220                 


Leu Ile Val Cys Val Ser Thr Gln Ile Asn Tyr Leu Asn Arg Ala Leu 
225                 230                 235                 240 


Asp Ile Phe Asn Thr Ser Ile Val Thr Pro Ile Tyr Tyr Val Phe Phe 
                245                 250                 255     


Thr Thr Ser Val Leu Thr Cys Ser Ala Ile Leu Phe Lys Glu Trp Gln 
            260                 265                 270         


Asp Met Pro Val Asp Asp Val Ile Gly Thr Leu Ser Gly Phe Phe Thr 
        275                 280                 285             


Ile Ile Val Gly Ile Phe Leu Leu His Ala Phe Lys Asp Val Ser Phe 
    290                 295                 300                 


Ser Leu Ala Ser Leu Pro Val Ser Phe Arg Lys Asp Glu Lys Ala Met 
305                 310                 315                 320 


Asn Gly Asn Leu Ser Asn Met Tyr Glu Val Leu Asn Asn Asn Glu Glu 
                325                 330                 335     


Ser Leu Thr Cys Gly Ile Glu Gln His Thr Gly Glu Asn Val Ser Arg 
            340                 345                 350         


Arg Asn Gly Asn Leu Thr Ala Phe 
        355                 360 


<210>  5193
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  5193

Met Glu Pro Ala Ala Gly Ile Gln Arg Arg Ser Ser Gln Gly Pro Thr 
1               5                   10                  15      


Val Pro Pro Pro Pro Arg Gly His Ala Pro Pro Ala Ala Ala Pro Gly 
            20                  25                  30          


Pro Ala Pro Leu Ser Ser Pro Val Arg Glu Pro Pro Gln Leu Glu Glu 
        35                  40                  45              


Glu Arg Gln Val Arg Ile Ser Glu Ser Gly Gln Phe Ser Asp Gly Leu 
    50                  55                  60                  


Glu Asp Arg Gly Leu Leu Glu Ser Ser Thr Arg Leu Lys Pro His Glu 
65                  70                  75                  80  


Ala Gln Asn Tyr Arg Lys Lys Ala Leu Trp Val Ser Trp Phe Ser Ile 
                85                  90                  95      


Ile Val Thr Leu Ala Leu Ala Val Ala Ala Phe Thr Val Ser Val Met 
            100                 105                 110         


Arg Tyr Ser Ala Ser Ala Phe Gly Phe Ala Phe Asp Ala Ile Leu Asp 
        115                 120                 125             


Val Leu Ser Ser Ala Ile Val Leu Trp Arg Tyr Ser Asn Ala Ala Ala 
    130                 135                 140                 


Val His Ser Ala His Arg Glu Tyr Ile Ala Cys Val Ile Leu Gly Val 
145                 150                 155                 160 


Ile Phe Leu Leu Ser Ser Ile Cys Ile Val Val Lys Ala Ile His Asp 
                165                 170                 175     


Leu Ser Thr Arg Leu Leu Pro Glu Val Asp Asp Phe Leu Phe Ser Val 
            180                 185                 190         


Ser Ile Leu Ser Gly Ile Leu Cys Ser Ile Leu Ala Val Leu Lys Phe 
        195                 200                 205             


Met Leu Gly Lys Val Leu Thr Ser Arg Ala Leu Ile Thr Asp Gly Phe 
    210                 215                 220                 


Asn Ser Leu Val Gly Gly Val Met Gly Phe Ser Ile Leu Leu Ser Ala 
225                 230                 235                 240 


Glu Val Phe Lys His Asp Ser Ala Val Trp Tyr Leu Asp Gly Ser Ile 
                245                 250                 255     


Gly Val Leu Ile Gly Leu Thr Ile Phe Ala Tyr Gly Val Lys Leu Leu 
            260                 265                 270         


Ile Asp Met Val Pro Arg Val Arg Gln Thr Arg His Tyr Glu Met Phe 
        275                 280                 285             


Glu 
    


<210>  5194
<211>  666
<212>  PRT
<213>  Homo sapiens

<400>  5194

Met Thr Gly Thr Pro Lys Thr Gln Glu Gly Ala Lys Asp Leu Glu Val 
1               5                   10                  15      


Asp Met Asn Lys Thr Glu Val Thr Pro Arg Leu Trp Thr Thr Cys Arg 
            20                  25                  30          


Asp Gly Glu Val Leu Leu Arg Leu Ser Lys His Gly Pro Gly His Glu 
        35                  40                  45              


Thr Pro Met Thr Ile Pro Glu Phe Phe Arg Glu Ser Val Asn Arg Phe 
    50                  55                  60                  


Gly Thr Tyr Pro Ala Leu Ala Ser Lys Asn Gly Lys Lys Trp Glu Ile 
65                  70                  75                  80  


Leu Asn Phe Asn Gln Tyr Tyr Glu Ala Cys Arg Lys Ala Ala Lys Ser 
                85                  90                  95      


Leu Ile Lys Leu Gly Leu Glu Arg Phe His Gly Val Gly Ile Leu Gly 
            100                 105                 110         


Phe Asn Ser Ala Glu Trp Phe Ile Thr Ala Val Gly Ala Ile Leu Ala 
        115                 120                 125             


Gly Gly Leu Cys Val Gly Ile Tyr Ala Thr Asn Ser Ala Glu Val Cys 
    130                 135                 140                 


Gln Tyr Val Ile Thr His Ala Lys Val Asn Ile Leu Leu Val Glu Asn 
145                 150                 155                 160 


Asp Gln Gln Leu Gln Lys Ile Leu Ser Ile Pro Gln Ser Ser Leu Glu 
                165                 170                 175     


Pro Leu Lys Ala Ile Ile Gln Tyr Arg Leu Pro Met Lys Lys Asn Asn 
            180                 185                 190         


Asn Leu Tyr Ser Trp Asp Asp Phe Met Glu Leu Gly Arg Ser Ile Pro 
        195                 200                 205             


Asp Thr Gln Leu Glu Gln Val Ile Glu Ser Gln Lys Ala Asn Gln Cys 
    210                 215                 220                 


Ala Val Leu Ile Tyr Thr Ser Gly Thr Thr Gly Ile Pro Lys Gly Val 
225                 230                 235                 240 


Met Leu Ser His Asp Asn Ile Thr Trp Ile Ala Gly Ala Val Thr Lys 
                245                 250                 255     


Asp Phe Lys Leu Thr Asp Lys His Glu Thr Val Val Ser Tyr Leu Pro 
            260                 265                 270         


Leu Ser His Ile Ala Ala Gln Met Met Asp Ile Trp Val Pro Ile Lys 
        275                 280                 285             


Ile Gly Ala Leu Thr Tyr Phe Ala Gln Ala Asp Ala Leu Lys Gly Thr 
    290                 295                 300                 


Leu Val Ser Thr Leu Lys Glu Val Lys Pro Thr Val Phe Ile Gly Val 
305                 310                 315                 320 


Pro Gln Ile Trp Glu Lys Ile His Glu Met Val Lys Lys Asn Ser Ala 
                325                 330                 335     


Lys Ser Met Gly Leu Lys Lys Lys Ala Phe Val Trp Ala Arg Asn Ile 
            340                 345                 350         


Gly Phe Lys Val Asn Ser Lys Lys Met Leu Gly Lys Tyr Asn Thr Pro 
        355                 360                 365             


Val Ser Tyr Arg Met Ala Lys Thr Leu Val Phe Ser Lys Val Lys Thr 
    370                 375                 380                 


Ser Leu Gly Leu Asp His Cys His Ser Phe Ile Ser Gly Thr Ala Pro 
385                 390                 395                 400 


Leu Asn Gln Glu Thr Ala Glu Phe Phe Leu Ser Leu Asp Ile Pro Ile 
                405                 410                 415     


Gly Glu Leu Tyr Gly Leu Ser Glu Ser Ser Gly Pro His Thr Ile Ser 
            420                 425                 430         


Asn Gln Asn Asn Tyr Arg Leu Leu Ser Cys Gly Lys Ile Leu Thr Gly 
        435                 440                 445             


Cys Lys Asn Met Leu Phe Gln Gln Asn Lys Asp Gly Ile Gly Glu Ile 
    450                 455                 460                 


Cys Leu Trp Gly Arg His Ile Phe Met Gly Tyr Leu Glu Ser Glu Thr 
465                 470                 475                 480 


Glu Thr Thr Glu Ala Ile Asp Asp Glu Gly Trp Leu His Ser Gly Asp 
                485                 490                 495     


Leu Gly Gln Leu Asp Gly Leu Gly Phe Leu Tyr Val Thr Gly His Ile 
            500                 505                 510         


Lys Glu Ile Leu Ile Thr Ala Gly Gly Glu Asn Val Pro Pro Ile Pro 
        515                 520                 525             


Val Glu Thr Leu Val Lys Lys Lys Ile Pro Ile Ile Ser Asn Ala Met 
    530                 535                 540                 


Leu Val Gly Asp Lys Leu Lys Phe Leu Ser Met Leu Leu Thr Leu Lys 
545                 550                 555                 560 


Cys Glu Met Asn Gln Met Ser Gly Glu Pro Leu Asp Lys Leu Asn Phe 
                565                 570                 575     


Glu Ala Ile Asn Phe Cys Arg Gly Leu Gly Ser Gln Ala Ser Thr Val 
            580                 585                 590         


Thr Glu Ile Val Lys Gln Gln Asp Pro Leu Val Tyr Lys Ala Ile Gln 
        595                 600                 605             


Gln Gly Ile Asn Ala Val Asn Gln Glu Ala Met Asn Asn Ala Gln Arg 
    610                 615                 620                 


Ile Glu Lys Trp Val Ile Leu Glu Lys Asp Phe Ser Ile Tyr Gly Gly 
625                 630                 635                 640 


Glu Leu Gly Pro Met Met Lys Leu Lys Arg His Phe Val Ala Gln Lys 
                645                 650                 655     


Tyr Lys Lys Gln Ile Asp His Met Tyr His 
            660                 665     


<210>  5195
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  5195

Met His Tyr Tyr Arg Tyr Ser Asn Ala Lys Val Ser Cys Trp Tyr Lys 
1               5                   10                  15      


Tyr Leu Leu Phe Ser Tyr Asn Ile Ile Phe Trp Leu Ala Gly Val Val 
            20                  25                  30          


Phe Leu Gly Val Gly Leu Trp Ala Trp Ser Glu Lys Gly Val Leu Ser 
        35                  40                  45              


Asp Leu Thr Lys Val Thr Arg Met His Gly Ile Asp Pro Val Val Leu 
    50                  55                  60                  


Val Leu Met Val Gly Val Val Met Phe Thr Leu Gly Phe Ala Gly Cys 
65                  70                  75                  80  


Val Gly Ala Leu Arg Glu Asn Ile Cys Leu Leu Asn Phe Phe Cys Gly 
                85                  90                  95      


Thr Ile Val Leu Ile Phe Phe Leu Glu Leu Ala Val Ala Val Leu Ala 
            100                 105                 110         


Phe Leu Phe Gln Asp Trp Val Arg Asp Arg Phe Arg Glu Phe Phe Glu 
        115                 120                 125             


Ser Asn Ile Lys Ser Tyr Arg Asp Asp Ile Asp Leu Gln Asn Leu Ile 
    130                 135                 140                 


Asp Ser Leu Gln Lys Ala Asn Gln Cys Cys Gly Ala Tyr Gly Pro Glu 
145                 150                 155                 160 


Asp Trp Asp Leu Asn Val Tyr Phe Asn Cys Ser Gly Ala Ser Tyr Ser 
                165                 170                 175     


Arg Glu Lys Cys Gly Val Pro Phe Ser Cys Cys Val Pro Asp Pro Ala 
            180                 185                 190         


Gln Lys Val Val Asn Thr Gln Cys Gly Tyr Asp Val Arg Ile Gln Leu 
        195                 200                 205             


Lys Ser Lys Trp Asp Glu Ser Ile Phe Thr Lys Gly Cys Ile Gln Ala 
    210                 215                 220                 


Leu Glu Ser Trp Leu Pro Arg Asn Ile Tyr Ile Val Ala Gly Val Phe 
225                 230                 235                 240 


Ile Ala Ile Ser Leu Leu Gln Ile Phe Gly Ile Phe Leu Ala Arg Thr 
                245                 250                 255     


Leu Ile Ser Asp Ile Glu Ala Val Lys Ala Gly His His Phe 
            260                 265                 270 


<210>  5196
<211>  597
<212>  PRT
<213>  Homo sapiens

<400>  5196

Met Glu Ala Glu Pro Pro Leu Tyr Pro Met Ala Gly Ala Ala Gly Pro 
1               5                   10                  15      


Gln Gly Asp Glu Asp Leu Leu Gly Val Pro Asp Gly Pro Glu Ala Pro 
            20                  25                  30          


Leu Asp Glu Leu Val Gly Ala Tyr Pro Asn Tyr Asn Glu Glu Glu Glu 
        35                  40                  45              


Glu Arg Arg Tyr Tyr Arg Arg Lys Arg Leu Gly Val Leu Lys Asn Val 
    50                  55                  60                  


Leu Ala Ala Ser Ala Gly Gly Met Leu Thr Tyr Gly Val Tyr Leu Gly 
65                  70                  75                  80  


Leu Leu Gln Met Gln Leu Ile Leu His Tyr Asp Glu Thr Tyr Arg Glu 
                85                  90                  95      


Val Lys Tyr Gly Asn Met Gly Leu Pro Asp Ile Asp Ser Lys Met Leu 
            100                 105                 110         


Met Gly Ile Asn Val Thr Pro Ile Ala Ala Leu Leu Tyr Thr Pro Val 
        115                 120                 125             


Leu Ile Arg Phe Phe Gly Thr Lys Trp Met Met Phe Leu Ala Val Gly 
    130                 135                 140                 


Ile Tyr Ala Leu Phe Val Ser Thr Asn Tyr Trp Glu Arg Tyr Tyr Thr 
145                 150                 155                 160 


Leu Val Pro Ser Ala Val Ala Leu Gly Met Ala Ile Val Pro Leu Trp 
                165                 170                 175     


Ala Ser Met Gly Asn Tyr Ile Thr Arg Met Ala Gln Lys Tyr His Glu 
            180                 185                 190         


Tyr Ser His Tyr Lys Glu Gln Asp Gly Gln Gly Met Lys Gln Arg Pro 
        195                 200                 205             


Pro Arg Gly Ser His Ala Pro Tyr Leu Leu Val Phe Gln Ala Ile Phe 
    210                 215                 220                 


Tyr Ser Phe Phe His Leu Ser Phe Ala Cys Ala Gln Leu Pro Met Ile 
225                 230                 235                 240 


Tyr Phe Leu Asn His Tyr Leu Tyr Asp Leu Asn His Thr Leu Tyr Asn 
                245                 250                 255     


Val Gln Ser Cys Gly Thr Asn Ser His Gly Ile Leu Ser Gly Phe Asn 
            260                 265                 270         


Lys Thr Val Leu Arg Thr Leu Pro Arg Ser Gly Asn Leu Ile Val Val 
        275                 280                 285             


Glu Ser Val Leu Met Ala Val Ala Phe Leu Ala Met Leu Leu Val Leu 
    290                 295                 300                 


Gly Leu Cys Gly Ala Ala Tyr Arg Pro Thr Glu Glu Ile Asp Leu Arg 
305                 310                 315                 320 


Ser Val Gly Trp Gly Asn Ile Phe Gln Leu Pro Phe Lys His Val Arg 
                325                 330                 335     


Asp Tyr Arg Leu Arg His Leu Val Pro Phe Phe Ile Tyr Ser Gly Phe 
            340                 345                 350         


Glu Val Leu Phe Ala Cys Thr Gly Ile Ala Leu Gly Tyr Gly Val Cys 
        355                 360                 365             


Ser Val Gly Leu Glu Arg Leu Ala Tyr Leu Leu Val Ala Tyr Ser Leu 
    370                 375                 380                 


Gly Ala Ser Ala Ala Ser Leu Leu Gly Leu Leu Gly Leu Trp Leu Pro 
385                 390                 395                 400 


Arg Pro Val Pro Leu Val Ala Gly Ala Gly Val His Leu Leu Leu Thr 
                405                 410                 415     


Phe Ile Leu Phe Phe Trp Ala Pro Val Pro Arg Val Leu Gln His Ser 
            420                 425                 430         


Trp Ile Leu Tyr Val Ala Ala Ala Leu Trp Gly Val Gly Ser Ala Leu 
        435                 440                 445             


Asn Lys Thr Gly Leu Ser Thr Leu Leu Gly Ile Leu Tyr Glu Asp Lys 
    450                 455                 460                 


Glu Arg Gln Asp Phe Ile Phe Thr Ile Tyr His Trp Trp Gln Ala Val 
465                 470                 475                 480 


Ala Ile Phe Thr Val Tyr Leu Gly Ser Ser Leu His Met Lys Ala Lys 
                485                 490                 495     


Leu Ala Val Leu Leu Val Thr Leu Val Ala Ala Ala Val Ser Tyr Leu 
            500                 505                 510         


Arg Met Glu Gln Lys Leu Arg Arg Gly Val Ala Pro Arg Gln Pro Arg 
        515                 520                 525             


Ile Pro Arg Pro Gln His Lys Val Arg Gly Tyr Arg Tyr Leu Glu Glu 
    530                 535                 540                 


Asp Asn Ser Asp Glu Ser Asp Ala Glu Gly Glu His Gly Asp Gly Ala 
545                 550                 555                 560 


Glu Glu Glu Ala Pro Pro Ala Gly Pro Arg Pro Gly Pro Glu Pro Ala 
                565                 570                 575     


Gly Leu Gly Arg Arg Pro Cys Pro Tyr Glu Gln Ala Gln Gly Gly Asp 
            580                 585                 590         


Gly Pro Glu Glu Gln 
        595         


<210>  5197
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  5197

Met Lys Ser Leu Leu Phe Thr Leu Ala Val Phe Met Leu Leu Ala Gln 
1               5                   10                  15      


Leu Val Ser Gly Asn Trp Tyr Val Lys Lys Cys Leu Asn Asp Val Gly 
            20                  25                  30          


Ile Cys Lys Lys Lys Cys Lys Pro Glu Glu Met His Val Lys Asn Gly 
        35                  40                  45              


Trp Ala Met Cys Gly Lys Gln Arg Asp Cys Cys Val Pro Ala Asp Arg 
    50                  55                  60                  


Arg Ala Asn Tyr Pro Val Phe Cys Val Gln Thr Lys Thr Thr Arg Ile 
65                  70                  75                  80  


Ser Thr Val Thr Ala Thr Thr Ala Thr Thr Thr Leu Met Met Thr Thr 
                85                  90                  95      


Ala Ser Met Ser Ser Met Ala Pro Thr Pro Val Ser Pro Thr Gly 
            100                 105                 110     


<210>  5198
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  5198

Met Ala Ala Ala Ala Ala Ala Ala Gly Ala Ala Gly Ser Ala Ala Pro 
1               5                   10                  15      


Ala Ala Ala Ala Gly Ala Pro Gly Ser Gly Gly Ala Pro Ser Gly Ser 
            20                  25                  30          


Gln Gly Val Leu Ile Gly Asp Arg Leu Tyr Ser Gly Val Leu Ile Thr 
        35                  40                  45              


Leu Glu Asn Cys Leu Leu Pro Asp Asp Lys Leu Arg Phe Thr Pro Ser 
    50                  55                  60                  


Met Ser Ser Gly Leu Asp Thr Asp Thr Glu Thr Asp Leu Arg Val Val 
65                  70                  75                  80  


Gly Cys Glu Leu Ile Gln Ala Ala Gly Ile Leu Leu Arg Leu Pro Gln 
                85                  90                  95      


Val Ala Met Ala Thr Gly Gln Val Leu Phe Gln Arg Phe Phe Tyr Thr 
            100                 105                 110         


Lys Ser Phe Val Lys His Ser Met Glu His Val Ser Met Ala Cys Val 
        115                 120                 125             


His Leu Ala Ser Lys Ile Glu Glu Ala Pro Arg Arg Ile Arg Asp Val 
    130                 135                 140                 


Ile Asn Val Phe His Arg Leu Arg Gln Leu Arg Asp Lys Lys Lys Pro 
145                 150                 155                 160 


Val Pro Leu Leu Leu Asp Gln Asp Tyr Val Asn Leu Lys Asn Gln Ile 
                165                 170                 175     


Ile Lys Ala Glu Arg Arg Val Leu Lys Glu Leu Gly Phe Cys Val His 
            180                 185                 190         


Val Lys His Pro His Lys Ile Ile Val Met Tyr Leu Gln Val Leu Glu 
        195                 200                 205             


Cys Glu Arg Asn Gln His Leu Val Gln Thr Ser Trp Asn Tyr Met Asn 
    210                 215                 220                 


Asp Ser Leu Arg Thr Asp Val Phe Val Arg Phe Gln Pro Glu Ser Ile 
225                 230                 235                 240 


Ala Cys Ala Cys Ile Tyr Leu Ala Ala Arg Thr Leu Glu Ile Pro Leu 
                245                 250                 255     


Pro Asn Arg Pro His Trp Phe Leu Leu Phe Gly Ala Thr Glu Glu Glu 
            260                 265                 270         


Ile Gln Glu Ile Cys Leu Lys Ile Leu Gln Leu Tyr Ala Arg Lys Lys 
        275                 280                 285             


Val Asp Leu Thr His Leu Glu Gly Glu Val Glu Lys Arg Lys His Ala 
    290                 295                 300                 


Ile Glu Glu Ala Lys Ala Gln Ala Arg Gly Leu Leu Pro Gly Gly Thr 
305                 310                 315                 320 


Gln Val Leu Asp Gly Thr Ser Gly Phe Ser Pro Ala Pro Lys Leu Val 
                325                 330                 335     


Glu Ser Pro Lys Glu Gly Lys Gly Ser Lys Pro Ser Pro Leu Ser Val 
            340                 345                 350         


Lys Asn Thr Lys Arg Arg Leu Glu Gly Ala Lys Lys Ala Lys Ala Asp 
        355                 360                 365             


Ser Pro Val Asn Gly Leu Pro Lys Gly Arg Glu Ser Arg Ser Arg Ser 
    370                 375                 380                 


Arg Ser Arg Glu Gln Ser Tyr Ser Arg Ser Pro Ser Arg Ser Ala Ser 
385                 390                 395                 400 


Pro Lys Arg Arg Lys Ser Asp Ser Gly Ser Thr Ser Gly Gly Ser Lys 
                405                 410                 415     


Ser Gln Ser Arg Ser Arg Ser Arg Ser Asp Ser Pro Pro Arg Gln Ala 
            420                 425                 430         


Pro Arg Ser Ala Pro Tyr Lys Gly Ser Glu Ile Arg Gly Ser Arg Lys 
        435                 440                 445             


Ser Lys Asp Cys Lys Tyr Pro Gln Lys Pro His Lys Ser Arg Ser Arg 
    450                 455                 460                 


Ser Ser Ser Arg Ser Arg Ser Arg Ser Arg Glu Arg Ala Asp Asn Pro 
465                 470                 475                 480 


Gly Lys Tyr Lys Lys Lys Ser His Tyr Tyr Arg Asp Gln Arg Arg Glu 
                485                 490                 495     


Arg Ser Arg Ser Tyr Glu Arg Thr Gly Arg Arg Tyr Glu Arg Asp His 
            500                 505                 510         


Pro Gly His Ser Arg His Arg Arg 
        515                 520 


<210>  5199
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  5199

Met Gly Val Leu Gly Arg Val Leu Leu Trp Leu Gln Leu Cys Ala Leu 
1               5                   10                  15      


Thr Gln Ala Val Ser Lys Leu Trp Val Pro Asn Thr Asp Phe Asp Val 
            20                  25                  30          


Ala Ala Asn Trp Ser Gln Asn Arg Thr Pro Cys Ala Gly Gly Ala Val 
        35                  40                  45              


Glu Phe Pro Ala Asp Lys Met Val Ser Val Leu Val Gln Glu Gly His 
    50                  55                  60                  


Ala Val Ser Asp Met Leu Leu Pro Leu Asp Gly Glu Leu Val Leu Ala 
65                  70                  75                  80  


Ser Gly Ala Gly Phe Gly Val Ser Asp Val Gly Ser His Leu Asp Cys 
                85                  90                  95      


Gly Ala Gly Glu Pro Ala Val Phe Arg Asp Ser Asp Arg Phe Ser Trp 
            100                 105                 110         


His Asp Pro His Leu Trp Arg Ser Gly Asp Glu Ala Pro Gly Leu Phe 
        115                 120                 125             


Phe Val Asp Ala Glu Arg Val Pro Cys Arg His Asp Asp Val Phe Phe 
    130                 135                 140                 


Pro Pro Ser Ala Ser Phe Arg Val Gly Leu Gly Pro Gly Ala Ser Pro 
145                 150                 155                 160 


Val Arg Val Arg Ser Ile Ser Ala Leu Gly Arg Thr Phe Thr Arg Asp 
                165                 170                 175     


Glu Asp Leu Ala Val Phe Leu Ala Ser Arg Ala Gly Arg Leu Arg Phe 
            180                 185                 190         


His Gly Pro Gly Ala Leu Ser Val Gly Pro Glu Asp Cys Ala Asp Pro 
        195                 200                 205             


Ser Gly Cys Val Cys Gly Asn Ala Glu Ala Gln Pro Trp Ile Cys Ala 
    210                 215                 220                 


Ala Leu Leu Gln Pro Leu Gly Gly Arg Cys Pro Gln Ala Ala Cys His 
225                 230                 235                 240 


Ser Ala Leu Arg Pro Gln Gly Gln Cys Cys Asp Leu Cys Gly Ala Val 
                245                 250                 255     


Val Leu Leu Thr His Gly Pro Ala Phe Asp Leu Glu Arg Tyr Arg Ala 
            260                 265                 270         


Arg Ile Leu Asp Thr Phe Leu Gly Leu Pro Gln Tyr His Gly Leu Gln 
        275                 280                 285             


Val Ala Val Ser Lys Val Pro Arg Ser Ser Arg Leu Arg Glu Ala Asp 
    290                 295                 300                 


Thr Glu Ile Gln Val Val Leu Val Glu Asn Gly Pro Glu Thr Gly Gly 
305                 310                 315                 320 


Ala Gly Arg Leu Ala Arg Ala Leu Leu Ala Asp Val Ala Glu Asn Gly 
                325                 330                 335     


Glu Ala Leu Gly Val Leu Glu Ala Thr Met Arg Glu Ser Gly Ala His 
            340                 345                 350         


Val Trp Gly Ser Ser Ala Ala Gly Leu Ala Gly Gly Val Ala Ala Ala 
        355                 360                 365             


Val Leu Leu Ala Leu Leu Val Leu Leu Val Ala Pro Pro Leu Leu Arg 
    370                 375                 380                 


Arg Ala Gly Arg Leu Arg Trp Arg Arg His Glu Ala Ala Ala Pro Ala 
385                 390                 395                 400 


Gly Ala Pro Leu Gly Phe Arg Asn Pro Val Phe Asp Val Thr Ala Ser 
                405                 410                 415     


Glu Glu Leu Pro Leu Pro Arg Arg Leu Ser Leu Val Pro Lys Ala Ala 
            420                 425                 430         


Ala Asp Ser Thr Ser His Ser Tyr Phe Val Asn Pro Leu Phe Ala Gly 
        435                 440                 445             


Ala Glu Ala Glu Ala 
    450             


<210>  5200
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  5200

Met Val Asn Leu Thr Ser Met Ser Gly Phe Leu Leu Met Gly Phe Ser 
1               5                   10                  15      


Asp Glu Arg Lys Leu Gln Ile Leu His Ala Leu Val Phe Leu Val Thr 
            20                  25                  30          


Tyr Leu Leu Ala Leu Thr Gly Asn Leu Leu Ile Ile Thr Ile Ile Thr 
        35                  40                  45              


Val Asp Arg Arg Leu His Ser Pro Met Tyr Tyr Phe Leu Lys His Leu 
    50                  55                  60                  


Ser Leu Leu Asp Leu Cys Phe Ile Ser Val Thr Val Pro Gln Ser Ile 
65                  70                  75                  80  


Ala Asn Ser Leu Met Gly Asn Gly Tyr Ile Ser Leu Val Gln Cys Ile 
                85                  90                  95      


Leu Gln Val Phe Phe Phe Ile Ala Leu Ala Ser Ser Glu Val Ala Ile 
            100                 105                 110         


Leu Thr Val Met Ser Tyr Asp Arg Tyr Ala Ala Ile Cys Gln Pro Leu 
        115                 120                 125             


His Tyr Glu Thr Ile Met Asp Pro Arg Ala Cys Arg His Ala Val Ile 
    130                 135                 140                 


Ala Val Trp Ile Ala Gly Gly Leu Ser Gly Leu Met His Ala Ala Ile 
145                 150                 155                 160 


Asn Phe Ser Ile Pro Leu Cys Gly Lys Arg Val Ile His Gln Phe Phe 
                165                 170                 175     


Cys Asp Val Pro Gln Met Leu Lys Leu Ala Cys Ser Tyr Glu Phe Ile 
            180                 185                 190         


Asn Glu Ile Ala Leu Ala Ala Phe Thr Thr Ser Ala Ala Phe Ile Cys 
        195                 200                 205             


Leu Ile Ser Ile Val Leu Ser Tyr Ile Arg Ile Phe Ser Thr Val Leu 
    210                 215                 220                 


Arg Ile Pro Ser Ala Glu Gly Arg Thr Lys Val Phe Ser Thr Cys Leu 
225                 230                 235                 240 


Pro His Leu Phe Val Ala Thr Phe Phe Leu Ser Ala Ala Gly Phe Glu 
                245                 250                 255     


Phe Leu Arg Leu Pro Ser Asp Ser Ser Ser Thr Val Asp Leu Val Phe 
            260                 265                 270         


Ser Val Phe Tyr Thr Val Ile Pro Pro Thr Leu Asn Pro Val Ile Tyr 
        275                 280                 285             


Ser Leu Arg Asn Asp Ser Met Lys Ala Ala Leu Arg Lys Met Leu Ser 
    290                 295                 300                 


Lys Glu Glu Leu Pro Gln Arg Lys Met Cys Leu Lys Ala Met Phe Lys 
305                 310                 315                 320 


Leu 
    


<210>  5201
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  5201

Met Ala Lys Tyr Gln Gly Glu Val Gln Ser Leu Lys Leu Asp Asp Asp 
1               5                   10                  15      


Ser Val Ile Glu Gly Val Ser Asp Gln Val Leu Val Ala Val Val Val 
            20                  25                  30          


Ser Phe Ala Leu Ile Ala Thr Leu Val Tyr Ala Leu Phe Arg Asn Val 
        35                  40                  45              


His Gln Asn Ile His Pro Glu Asn Gln Glu Leu Val Arg Val Leu Arg 
    50                  55                  60                  


Glu Gln Leu Gln Thr Glu Gln Asp Ala Pro Ala Ala Thr Arg Gln Gln 
65                  70                  75                  80  


Phe Tyr Thr Asp Met Tyr Cys Pro Ile Cys Leu His Gln Ala Ser Phe 
                85                  90                  95      


Pro Val Glu Thr Asn Cys Gly His Leu Phe Cys Gly Ala Cys Ile Ile 
            100                 105                 110         


Ala Tyr Trp Arg Tyr Gly Ser Trp Leu Gly Ala Ile Ser Cys Pro Ile 
        115                 120                 125             


Cys Arg Gln Thr Val Thr Leu Leu Leu Thr Val Phe Gly Glu Asp Asp 
    130                 135                 140                 


Gln Ser Gln Asp Val Leu Arg Leu His Gln Asp Ile Asn Asp Tyr Asn 
145                 150                 155                 160 


Arg Arg Phe Ser Gly Gln Pro Arg Ser Ile Met Glu Arg Ile Met Asp 
                165                 170                 175     


Leu Pro Thr Leu Leu Arg His Ala Phe Arg Glu Met Phe Ser Val Gly 
            180                 185                 190         


Gly Leu Phe Trp Met Phe Arg Ile Arg Ile Ile Leu Cys Leu Met Gly 
        195                 200                 205             


Ala Phe Phe Tyr Leu Ile Ser Pro Leu Asp Phe Val Pro Glu Ala Leu 
    210                 215                 220                 


Phe Gly Ile Leu Gly Phe Leu Asp Asp Phe Phe Val Ile Phe Leu Leu 
225                 230                 235                 240 


Leu Ile Tyr Ile Ser Ile Met Tyr Arg Glu Val Ile Thr Gln Arg Leu 
                245                 250                 255     


Thr Arg 
        


<210>  5202
<211>  811
<212>  PRT
<213>  Homo sapiens

<400>  5202

Met Arg Leu Ile Arg Asn Ile Tyr Ile Phe Cys Ser Ile Val Met Thr 
1               5                   10                  15      


Ala Glu Gly Asp Ala Pro Glu Leu Pro Glu Glu Arg Glu Leu Met Thr 
            20                  25                  30          


Asn Cys Ser Asn Met Ser Leu Arg Lys Val Pro Ala Asp Leu Thr Pro 
        35                  40                  45              


Ala Thr Thr Thr Leu Asp Leu Ser Tyr Asn Leu Leu Phe Gln Leu Gln 
    50                  55                  60                  


Ser Ser Asp Phe His Ser Val Ser Lys Leu Arg Val Leu Ile Leu Cys 
65                  70                  75                  80  


His Asn Arg Ile Gln Gln Leu Asp Leu Lys Thr Phe Glu Phe Asn Lys 
                85                  90                  95      


Glu Leu Arg Tyr Leu Asp Leu Ser Asn Asn Arg Leu Lys Ser Val Thr 
            100                 105                 110         


Trp Tyr Leu Leu Ala Gly Leu Arg Tyr Leu Asp Leu Ser Phe Asn Asp 
        115                 120                 125             


Phe Asp Thr Met Pro Ile Cys Glu Glu Ala Gly Asn Met Ser His Leu 
    130                 135                 140                 


Glu Ile Leu Gly Leu Ser Gly Ala Lys Ile Gln Lys Ser Asp Phe Gln 
145                 150                 155                 160 


Lys Ile Ala His Leu His Leu Asn Thr Val Phe Leu Gly Phe Arg Thr 
                165                 170                 175     


Leu Pro His Tyr Glu Glu Gly Ser Leu Pro Ile Leu Asn Thr Thr Lys 
            180                 185                 190         


Leu His Ile Val Leu Pro Met Asp Thr Asn Phe Trp Val Leu Leu Arg 
        195                 200                 205             


Asp Gly Ile Lys Thr Ser Lys Ile Leu Glu Met Thr Asn Ile Asp Gly 
    210                 215                 220                 


Lys Ser Gln Phe Val Ser Tyr Glu Met Gln Arg Asn Leu Ser Leu Glu 
225                 230                 235                 240 


Asn Ala Lys Thr Ser Val Leu Leu Leu Asn Lys Val Asp Leu Leu Trp 
                245                 250                 255     


Asp Asp Leu Phe Leu Ile Leu Gln Phe Val Trp His Thr Ser Val Glu 
            260                 265                 270         


His Phe Gln Ile Arg Asn Val Thr Phe Gly Gly Lys Ala Tyr Leu Asp 
        275                 280                 285             


His Asn Ser Phe Asp Tyr Ser Asn Thr Val Met Arg Thr Ile Lys Leu 
    290                 295                 300                 


Glu His Val His Phe Arg Val Phe Tyr Ile Gln Gln Asp Lys Ile Tyr 
305                 310                 315                 320 


Leu Leu Leu Thr Lys Met Asp Ile Glu Asn Leu Thr Ile Ser Asn Ala 
                325                 330                 335     


Gln Met Pro His Met Leu Phe Pro Asn Tyr Pro Thr Lys Phe Gln Tyr 
            340                 345                 350         


Leu Asn Phe Ala Asn Asn Ile Leu Thr Asp Glu Leu Phe Lys Arg Thr 
        355                 360                 365             


Ile Gln Leu Pro His Leu Lys Thr Leu Ile Leu Asn Gly Asn Lys Leu 
    370                 375                 380                 


Glu Thr Leu Ser Leu Val Ser Cys Phe Ala Asn Asn Thr Pro Leu Glu 
385                 390                 395                 400 


His Leu Asp Leu Ser Gln Asn Leu Leu Gln His Lys Asn Asp Glu Asn 
                405                 410                 415     


Cys Ser Trp Pro Glu Thr Val Val Asn Met Asn Leu Ser Tyr Asn Lys 
            420                 425                 430         


Leu Ser Asp Ser Val Phe Arg Cys Leu Pro Lys Ser Ile Gln Ile Leu 
        435                 440                 445             


Asp Leu Asn Asn Asn Gln Ile Gln Thr Val Pro Lys Glu Thr Ile His 
    450                 455                 460                 


Leu Met Ala Leu Arg Glu Leu Asn Ile Ala Phe Asn Phe Leu Thr Asp 
465                 470                 475                 480 


Leu Pro Gly Cys Ser His Phe Ser Arg Leu Ser Val Leu Asn Ile Glu 
                485                 490                 495     


Met Asn Phe Ile Leu Ser Pro Ser Leu Asp Phe Val Gln Ser Cys Gln 
            500                 505                 510         


Glu Val Lys Thr Leu Asn Ala Gly Arg Asn Pro Phe Arg Cys Thr Cys 
        515                 520                 525             


Glu Leu Lys Asn Phe Ile Gln Leu Glu Thr Tyr Ser Glu Val Met Met 
    530                 535                 540                 


Val Gly Trp Ser Asp Ser Tyr Thr Cys Glu Tyr Pro Leu Asn Leu Arg 
545                 550                 555                 560 


Gly Thr Arg Leu Lys Asp Val His Leu His Glu Leu Ser Cys Asn Thr 
                565                 570                 575     


Ala Leu Leu Ile Val Thr Ile Val Val Ile Met Leu Val Leu Gly Leu 
            580                 585                 590         


Ala Val Ala Phe Cys Cys Leu His Phe Asp Leu Pro Trp Tyr Leu Arg 
        595                 600                 605             


Met Leu Gly Gln Cys Thr Gln Thr Trp His Arg Val Arg Lys Thr Thr 
    610                 615                 620                 


Gln Glu Gln Leu Lys Arg Asn Val Arg Phe His Ala Phe Ile Ser Tyr 
625                 630                 635                 640 


Ser Glu His Asp Ser Leu Trp Val Lys Asn Glu Leu Ile Pro Asn Leu 
                645                 650                 655     


Glu Lys Glu Asp Gly Ser Ile Leu Ile Cys Leu Tyr Glu Ser Tyr Phe 
            660                 665                 670         


Asp Pro Gly Lys Ser Ile Ser Glu Asn Ile Val Ser Phe Ile Glu Lys 
        675                 680                 685             


Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Asn Glu 
    690                 695                 700                 


Trp Cys His Tyr Glu Phe Tyr Phe Ala His His Asn Leu Phe His Glu 
705                 710                 715                 720 


Asn Ser Asp His Ile Ile Leu Ile Leu Leu Glu Pro Ile Pro Phe Tyr 
                725                 730                 735     


Cys Ile Pro Thr Arg Tyr His Lys Leu Lys Ala Leu Leu Glu Lys Lys 
            740                 745                 750         


Ala Tyr Leu Glu Trp Pro Lys Asp Arg Arg Lys Cys Gly Leu Phe Trp 
        755                 760                 765             


Ala Asn Leu Arg Ala Ala Ile Asn Val Asn Val Leu Ala Thr Arg Glu 
    770                 775                 780                 


Met Tyr Glu Leu Gln Thr Phe Thr Glu Leu Asn Glu Glu Ser Arg Gly 
785                 790                 795                 800 


Ser Thr Ile Ser Leu Met Arg Thr Asp Cys Leu 
                805                 810     


<210>  5203
<211>  848
<212>  PRT
<213>  Homo sapiens

<400>  5203

Met Asp Glu Gly Thr Gly Leu Gln Pro Gly Ala Gly Glu Gln Leu Glu 
1               5                   10                  15      


Ala Pro Ala Thr Ala Glu Ala Val Gln Glu Arg Cys Glu Pro Glu Thr 
            20                  25                  30          


Leu Arg Ser Lys Ser Leu Pro Val Leu Ser Ser Ala Ser Cys Arg Pro 
        35                  40                  45              


Ser Leu Ser Pro Thr Ser Gly Asp Ala Asn Pro Ala Phe Gly Cys Val 
    50                  55                  60                  


Asp Ser Ser Gly His Gln Glu Leu Lys Gln Gly Pro Asn Pro Leu Ala 
65                  70                  75                  80  


Pro Ser Pro Ser Ala Pro Ser Thr Ser Ala Gly Leu Gly Asp Cys Asn 
                85                  90                  95      


His Arg Val Asp Leu Ser Lys Thr Phe Ser Val Ser Ser Ala Leu Ala 
            100                 105                 110         


Met Leu Gln Glu Arg Arg Cys Leu Tyr Val Val Leu Thr Asp Ser Arg 
        115                 120                 125             


Cys Phe Leu Val Cys Met Cys Phe Leu Thr Phe Ile Gln Ala Leu Met 
    130                 135                 140                 


Val Ser Gly Tyr Leu Ser Ser Val Ile Thr Thr Ile Glu Arg Arg Tyr 
145                 150                 155                 160 


Ser Leu Lys Ser Ser Glu Ser Gly Leu Leu Val Ser Cys Phe Asp Ile 
                165                 170                 175     


Gly Asn Leu Val Val Val Val Phe Val Ser Tyr Phe Gly Gly Arg Gly 
            180                 185                 190         


Arg Arg Pro Leu Trp Leu Ala Val Gly Gly Leu Leu Ile Ala Phe Gly 
        195                 200                 205             


Ala Ala Leu Phe Ala Leu Pro His Phe Ile Ser Pro Pro Tyr Gln Ile 
    210                 215                 220                 


Gln Glu Leu Asn Ala Ser Ala Pro Asn Asp Gly Leu Cys Gln Gly Gly 
225                 230                 235                 240 


Asn Ser Thr Ala Thr Leu Glu Pro Pro Ala Cys Pro Lys Asp Ser Gly 
                245                 250                 255     


Gly Asn Asn His Trp Val Tyr Val Ala Leu Phe Ile Cys Ala Gln Ile 
            260                 265                 270         


Leu Ile Gly Met Gly Ser Thr Pro Ile Tyr Thr Leu Gly Pro Thr Tyr 
        275                 280                 285             


Leu Asp Asp Asn Val Lys Lys Glu Asn Ser Ser Leu Tyr Leu Ala Ile 
    290                 295                 300                 


Met Tyr Val Met Gly Ala Leu Gly Pro Ala Val Gly Tyr Leu Leu Gly 
305                 310                 315                 320 


Gly Leu Leu Ile Gly Phe Tyr Val Asp Pro Arg Asn Pro Val His Leu 
                325                 330                 335     


Asp Gln Asn Asp Pro Arg Phe Ile Gly Asn Trp Trp Ser Gly Phe Leu 
            340                 345                 350         


Leu Cys Ala Ile Ala Met Phe Leu Val Ile Phe Pro Met Phe Thr Phe 
        355                 360                 365             


Pro Lys Lys Leu Pro Pro Arg His Lys Lys Lys Lys Lys Lys Lys Phe 
    370                 375                 380                 


Ser Val Asp Ala Val Ser Asp Asp Asp Val Leu Lys Glu Lys Ser Asn 
385                 390                 395                 400 


Asn Ser Glu Gln Ala Asp Lys Lys Val Ser Ser Met Gly Phe Gly Lys 
                405                 410                 415     


Asp Val Arg Asp Leu Pro Arg Ala Ala Val Arg Ile Leu Ser Asn Met 
            420                 425                 430         


Thr Phe Leu Phe Val Ser Leu Ser Tyr Thr Ala Glu Ser Ala Ile Val 
        435                 440                 445             


Thr Ala Phe Ile Thr Phe Ile Pro Lys Phe Ile Glu Ser Gln Phe Gly 
    450                 455                 460                 


Ile Pro Ala Ser Asn Ala Ser Ile Tyr Thr Gly Val Ile Ile Val Pro 
465                 470                 475                 480 


Ser Ala Gly Val Gly Ile Val Leu Gly Gly Tyr Ile Ile Lys Lys Leu 
                485                 490                 495     


Lys Leu Gly Ala Arg Glu Ser Ala Lys Leu Ala Met Ile Cys Ser Gly 
            500                 505                 510         


Val Ser Leu Leu Cys Phe Ser Thr Leu Phe Ile Val Gly Cys Glu Ser 
        515                 520                 525             


Ile Asn Leu Gly Gly Ile Asn Ile Pro Tyr Thr Thr Gly Pro Ser Leu 
    530                 535                 540                 


Thr Met Pro His Arg Asn Leu Thr Gly Ser Cys Asn Val Asn Cys Gly 
545                 550                 555                 560 


Cys Lys Ile His Glu Tyr Glu Pro Val Cys Gly Ser Asp Gly Ile Thr 
                565                 570                 575     


Tyr Phe Asn Pro Cys Leu Ala Gly Cys Val Asn Ser Gly Asn Leu Ser 
            580                 585                 590         


Thr Gly Ile Arg Asn Tyr Thr Glu Cys Thr Cys Val Gln Ser Arg Gln 
        595                 600                 605             


Val Ile Thr Pro Pro Thr Val Gly Gln Arg Ser Gln Leu Arg Val Val 
    610                 615                 620                 


Ile Val Lys Thr Tyr Leu Asn Glu Asn Gly Tyr Ala Val Ser Gly Lys 
625                 630                 635                 640 


Cys Lys Arg Thr Cys Asn Thr Leu Ile Pro Phe Leu Val Phe Leu Phe 
                645                 650                 655     


Ile Val Thr Phe Ile Thr Ala Cys Ala Gln Pro Ser Ala Ile Ile Val 
            660                 665                 670         


Thr Leu Arg Ser Val Glu Asp Glu Glu Arg Pro Phe Ala Leu Gly Met 
        675                 680                 685             


Gln Phe Val Leu Leu Arg Thr Leu Ala Tyr Ile Pro Thr Pro Ile Tyr 
    690                 695                 700                 


Phe Gly Ala Val Ile Asp Thr Thr Cys Met Leu Trp Gln Gln Glu Cys 
705                 710                 715                 720 


Gly Val Gln Gly Ser Cys Trp Glu Tyr Asn Val Thr Ser Phe Arg Phe 
                725                 730                 735     


Val Tyr Phe Gly Leu Ala Ala Gly Leu Lys Phe Val Gly Phe Ile Phe 
            740                 745                 750         


Ile Phe Leu Ala Trp Tyr Ser Ile Lys Tyr Lys Glu Asp Gly Leu Gln 
        755                 760                 765             


Arg Arg Arg Gln Arg Glu Phe Pro Leu Ser Thr Val Ser Glu Arg Val 
    770                 775                 780                 


Gly His Pro Asp Asn Ala Arg Thr Arg Ser Cys Pro Ala Phe Ser Thr 
785                 790                 795                 800 


Gln Gly Glu Phe His Glu Glu Thr Gly Leu Gln Lys Gly Ile Gln Cys 
                805                 810                 815     


Ala Ala Gln Thr Tyr Pro Gly Pro Phe Pro Glu Ala Ile Ser Ser Ser 
            820                 825                 830         


Ala Asp Pro Gly Leu Glu Glu Ser Pro Ala Ala Leu Glu Pro Pro Ser 
        835                 840                 845             


<210>  5204
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  5204

Met Glu Asn Val Thr Thr Met Asn Glu Phe Leu Leu Leu Gly Leu Thr 
1               5                   10                  15      


Gly Val Gln Glu Leu Gln Pro Phe Phe Phe Gly Ile Phe Leu Ile Ile 
            20                  25                  30          


Tyr Leu Ile Asn Leu Ile Gly Asn Gly Ser Ile Leu Val Met Val Val 
        35                  40                  45              


Leu Glu Pro Gln Leu His Ser Pro Met Tyr Phe Phe Leu Gly Asn Leu 
    50                  55                  60                  


Ser Cys Leu Asp Ile Ser Tyr Ser Ser Val Thr Leu Pro Lys Leu Leu 
65                  70                  75                  80  


Val Asn Leu Val Cys Ser Arg Arg Ala Ile Ser Phe Leu Gly Cys Ile 
                85                  90                  95      


Thr Gln Leu His Phe Phe His Phe Leu Gly Ser Thr Glu Ala Ile Leu 
            100                 105                 110         


Leu Ala Ile Met Ala Phe Asp Arg Phe Val Ala Ile Cys Asn Pro Leu 
        115                 120                 125             


Arg Tyr Thr Val Ile Met Asn Pro Gln Val Cys Ile Leu Leu Ala Ala 
    130                 135                 140                 


Ala Ala Trp Leu Ile Ser Phe Phe Tyr Ala Leu Met His Ser Val Met 
145                 150                 155                 160 


Thr Ala His Leu Ser Phe Cys Gly Ser Gln Lys Leu Asn His Phe Phe 
                165                 170                 175     


Tyr Asp Val Lys Pro Leu Leu Glu Leu Ala Cys Ser Asp Thr Leu Leu 
            180                 185                 190         


Asn Gln Trp Leu Leu Ser Ile Val Thr Gly Ser Ile Ser Met Gly Ala 
        195                 200                 205             


Phe Phe Leu Thr Leu Leu Ser Cys Phe Tyr Val Ile Gly Phe Leu Leu 
    210                 215                 220                 


Phe Lys Asn Arg Ser Cys Arg Ile Leu His Lys Ala Leu Ser Thr Cys 
225                 230                 235                 240 


Ala Ser His Phe Met Val Val Cys Leu Phe Tyr Gly Pro Val Gly Phe 
                245                 250                 255     


Thr Tyr Ile Arg Pro Ala Ser Ala Thr Ser Met Ile Gln Asp Arg Ile 
            260                 265                 270         


Met Ala Ile Met Tyr Ser Ala Val Thr Pro Val Leu Asn Pro Leu Ile 
        275                 280                 285             


Tyr Thr Leu Arg Asn Lys Glu Val Met Met Ala Leu Lys Lys Ile Phe 
    290                 295                 300                 


Gly Arg Lys Leu Phe Lys Asp Trp Gln Gln His His 
305                 310                 315     


<210>  5205
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  5205

Met Glu Arg Lys Asn Gln Thr Ala Ile Thr Glu Phe Ile Ile Leu Gly 
1               5                   10                  15      


Phe Ser Asn Leu Asn Glu Leu Gln Phe Leu Leu Phe Thr Ile Phe Phe 
            20                  25                  30          


Leu Thr Tyr Phe Cys Thr Leu Gly Gly Asn Ile Leu Ile Ile Leu Thr 
        35                  40                  45              


Thr Val Thr Asp Pro His Leu His Thr Pro Met Tyr Tyr Phe Leu Gly 
    50                  55                  60                  


Asn Leu Ala Phe Ile Asp Ile Cys Tyr Thr Thr Ser Asn Val Pro Gln 
65                  70                  75                  80  


Met Met Val His Leu Leu Ser Lys Lys Lys Ser Ile Ser Tyr Val Gly 
                85                  90                  95      


Cys Val Val Gln Leu Phe Ala Phe Val Phe Phe Val Gly Ser Glu Cys 
            100                 105                 110         


Leu Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ile Ala Ile Cys Asn 
        115                 120                 125             


Pro Leu Arg Tyr Ser Val Ile Leu Ser Lys Val Leu Cys Asn Gln Leu 
    130                 135                 140                 


Ala Ala Ser Cys Trp Ala Ala Gly Phe Leu Asn Ser Val Val His Thr 
145                 150                 155                 160 


Val Leu Thr Phe Cys Leu Pro Phe Cys Gly Asn Asn Gln Ile Asn Tyr 
                165                 170                 175     


Phe Phe Cys Asp Ile Pro Pro Leu Leu Ile Leu Ser Cys Gly Asn Thr 
            180                 185                 190         


Ser Val Asn Glu Leu Ala Leu Leu Ser Thr Gly Val Phe Ile Gly Trp 
        195                 200                 205             


Thr Pro Phe Leu Cys Ile Val Leu Ser Tyr Ile Cys Ile Ile Ser Thr 
    210                 215                 220                 


Ile Leu Arg Ile Gln Ser Ser Glu Gly Arg Arg Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Ala Ser His Leu Ala Ile Val Phe Leu Phe Tyr Gly Ser Ala Ile 
                245                 250                 255     


Phe Thr Tyr Val Arg Pro Ile Ser Thr Tyr Ser Leu Lys Lys Asp Arg 
            260                 265                 270         


Leu Val Ser Val Leu Tyr Ser Val Val Thr Pro Met Leu Asn Pro Ile 
        275                 280                 285             


Ile Tyr Thr Leu Arg Asn Lys Asp Ile Lys Glu Ala Val Lys Thr Ile 
    290                 295                 300                 


Gly Ser Lys Trp Gln Pro Pro Ile Ser Ser Leu Asp Ser Lys Leu Thr 
305                 310                 315                 320 


Tyr 
    


<210>  5206
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  5206

Met Ser Pro Arg Gly Thr Gly Cys Ser Ala Gly Leu Leu Met Thr Val 
1               5                   10                  15      


Gly Trp Leu Leu Leu Ala Gly Leu Gln Ser Ala Arg Gly Thr Asn Val 
            20                  25                  30          


Thr Ala Ala Val Gln Asp Ala Gly Leu Ala His Glu Gly Glu Gly Glu 
        35                  40                  45              


Glu Glu Thr Glu Asn Asn Asp Ser Glu Thr Ala Glu Asn Tyr Ala Pro 
    50                  55                  60                  


Pro Glu Thr Glu Asp Val Ser Asn Arg Asn Val Val Lys Glu Val Glu 
65                  70                  75                  80  


Phe Gly Met Cys Thr Val Thr Cys Gly Ile Gly Val Arg Glu Val Ile 
                85                  90                  95      


Leu Thr Asn Gly Cys Pro Gly Gly Glu Ser Lys Cys Val Val Arg Val 
            100                 105                 110         


Glu Glu Cys Arg Gly Pro Thr Asp Cys Gly Trp Gly Lys Pro Ile Ser 
        115                 120                 125             


Glu Ser Leu Glu Ser Val Arg Leu Ala Cys Ile His Thr Ser Pro Leu 
    130                 135                 140                 


Asn Arg Phe Lys Tyr Met Trp Lys Leu Leu Arg Gln Asp Gln Gln Ser 
145                 150                 155                 160 


Ile Ile Leu Val Asn Asp Ser Ala Ile Leu Glu Val Arg Lys Glu Ser 
                165                 170                 175     


His Pro Leu Ala Phe Glu Cys Asp Thr Leu Asp Asn Asn Glu Ile Val 
            180                 185                 190         


Ala Thr Ile Lys Phe Thr Val Tyr Thr Ser Ser Glu Leu Gln Met Arg 
        195                 200                 205             


Arg Ser Ser Leu Pro Ala Thr Asp Ala Ala Leu Ile Phe Val Leu Thr 
    210                 215                 220                 


Ile Gly Val Ile Ile Cys Val Phe Ile Ile Phe Leu Leu Ile Phe Ile 
225                 230                 235                 240 


Ile Ile Asn Trp Ala Ala Val Lys Ala Phe Trp Gly Ala Lys Ala Ser 
                245                 250                 255     


Thr Pro Glu Val Gln Ser Glu Gln Ser Ser Val Arg Tyr Lys Asp Ser 
            260                 265                 270         


Thr Ser Leu Asp Gln Leu Pro Thr Glu Met Pro Gly Glu Asp Asp Ala 
        275                 280                 285             


Leu Ser Glu Trp Asn Glu 
    290                 


<210>  5207
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  5207

Met Lys Thr Leu Met Arg His Gly Leu Ala Val Cys Leu Ala Leu Thr 
1               5                   10                  15      


Thr Met Cys Thr Ser Leu Leu Leu Val Tyr Ser Ser Leu Gly Gly Gln 
            20                  25                  30          


Lys Glu Arg Pro Pro Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        35                  40                  45              


Gln Ala Ser Ala Thr Gly Ser Ser Gln Pro Ala Ala Glu Ser Ser Thr 
    50                  55                  60                  


Gln Gln Arg Pro Gly Val Pro Ala Gly Pro Arg Pro Leu Asp Gly Tyr 
65                  70                  75                  80  


Leu Gly Val Ala Asp His Lys Pro Leu Lys Met His Cys Arg Asp Cys 
                85                  90                  95      


Ala Leu Val Thr Ser Ser Gly His Leu Leu His Ser Arg Gln Gly Ser 
            100                 105                 110         


Gln Ile Asp Gln Thr Glu Cys Val Ile Arg Met Asn Asp Ala Pro Thr 
        115                 120                 125             


Arg Gly Tyr Gly Arg Asp Val Gly Asn Arg Thr Ser Leu Arg Val Ile 
    130                 135                 140                 


Ala His Ser Ser Ile Gln Arg Ile Leu Arg Asn Arg His Asp Leu Leu 
145                 150                 155                 160 


Asn Val Ser Gln Gly Thr Val Phe Ile Phe Trp Gly Pro Ser Ser Tyr 
                165                 170                 175     


Met Arg Arg Asp Gly Lys Gly Gln Val Tyr Asn Asn Leu His Leu Leu 
            180                 185                 190         


Ser Gln Val Leu Pro Arg Leu Lys Ala Phe Met Ile Thr Arg His Lys 
        195                 200                 205             


Met Leu Gln Phe Asp Glu Leu Phe Lys Gln Glu Thr Gly Lys Asp Arg 
    210                 215                 220                 


Lys Ile Ser Asn Thr Trp Leu Ser Thr Gly Trp Phe Thr Met Thr Ile 
225                 230                 235                 240 


Ala Leu Glu Leu Cys Asp Arg Ile Asn Val Tyr Gly Met Val Pro Pro 
                245                 250                 255     


Asp Phe Cys Arg Asp Pro Asn His Pro Ser Val Pro Tyr His Tyr Tyr 
            260                 265                 270         


Glu Pro Phe Gly Pro Asp Glu Cys Thr Met Tyr Leu Ser His Glu Arg 
        275                 280                 285             


Gly Arg Lys Gly Ser His His Arg Phe Ile Thr Glu Lys Arg Val Phe 
    290                 295                 300                 


Lys Asn Trp Ala Arg Thr Phe Asn Ile His Phe Phe Gln Pro Asp Trp 
305                 310                 315                 320 


Lys Pro Glu Ser Leu Ala Ile Asn His Pro Glu Asn Lys Pro Val Phe 
                325                 330                 335     


<210>  5208
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  5208

Met Gly Ser Arg Gly Gln Gly Leu Leu Leu Ala Tyr Cys Leu Leu Leu 
1               5                   10                  15      


Ala Phe Ala Ser Gly Leu Val Leu Ser Arg Val Pro His Val Gln Gly 
            20                  25                  30          


Glu Gln Gln Glu Trp Glu Gly Thr Glu Glu Leu Pro Ser Pro Pro Asp 
        35                  40                  45              


His Ala Glu Arg Ala Glu Glu Gln His Glu Lys Tyr Arg Pro Ser Gln 
    50                  55                  60                  


Asp Gln Gly Leu Pro Ala Ser Arg Cys Leu Arg Cys Cys Asp Pro Gly 
65                  70                  75                  80  


Thr Ser Met Tyr Pro Ala Thr Ala Val Pro Gln Ile Asn Ile Thr Ile 
                85                  90                  95      


Leu Lys Gly Glu Lys Gly Asp Arg Gly Asp Arg Gly Leu Gln Gly Lys 
            100                 105                 110         


Tyr Gly Lys Thr Gly Ser Ala Gly Ala Arg Gly His Thr Gly Pro Lys 
        115                 120                 125             


Gly Gln Lys Gly Ser Met Gly Ala Pro Gly Glu Arg Cys Lys Ser His 
    130                 135                 140                 


Tyr Ala Ala Phe Ser Val Gly Arg Lys Lys Pro Met His Ser Asn His 
145                 150                 155                 160 


Tyr Tyr Gln Thr Val Ile Phe Asp Thr Glu Phe Val Asn Leu Tyr Asp 
                165                 170                 175     


His Phe Asn Met Phe Thr Gly Lys Phe Tyr Cys Tyr Val Pro Gly Leu 
            180                 185                 190         


Tyr Phe Phe Ser Leu Asn Val His Thr Trp Asn Gln Lys Glu Thr Tyr 
        195                 200                 205             


Leu His Ile Met Lys Asn Glu Glu Glu Val Val Ile Leu Phe Ala Gln 
    210                 215                 220                 


Val Gly Asp Arg Ser Ile Met Gln Ser Gln Ser Leu Met Leu Glu Leu 
225                 230                 235                 240 


Arg Glu Gln Asp Gln Val Trp Val Arg Leu Tyr Lys Gly Glu Arg Glu 
                245                 250                 255     


Asn Ala Ile Phe Ser Glu Glu Leu Asp Thr Tyr Ile Thr Phe Ser Gly 
            260                 265                 270         


Tyr Leu Val Lys His Ala Thr Glu Pro 
        275                 280     


<210>  5209
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  5209

Met Glu Ser Lys Met Gly Glu Leu Pro Leu Asp Ile Asn Ile Gln Glu 
1               5                   10                  15      


Pro Arg Trp Asp Gln Ser Thr Phe Leu Gly Arg Ala Arg His Phe Phe 
            20                  25                  30          


Thr Val Thr Asp Pro Arg Asn Leu Leu Leu Ser Gly Ala Gln Leu Glu 
        35                  40                  45              


Ala Ser Arg Asn Ile Val Gln Asn Tyr Arg Ala Gly Val Val Thr Pro 
    50                  55                  60                  


Gly Ile Thr Glu Asp Gln Leu Trp Arg Ala Lys Tyr Val Tyr Asp Ser 
65                  70                  75                  80  


Ala Phe His Pro Asp Thr Gly Glu Lys Val Val Leu Ile Gly Arg Met 
                85                  90                  95      


Ser Ala Gln Val Pro Met Asn Met Thr Ile Thr Gly Cys Met Leu Thr 
            100                 105                 110         


Phe Tyr Arg Lys Thr Pro Thr Val Val Phe Trp Gln Trp Val Asn Gln 
        115                 120                 125             


Ser Phe Asn Ala Ile Val Asn Tyr Ser Asn Arg Ser Gly Asp Thr Pro 
    130                 135                 140                 


Ile Thr Val Arg Gln Leu Gly Thr Ala Tyr Val Ser Ala Thr Thr Gly 
145                 150                 155                 160 


Ala Val Ala Thr Ala Leu Gly Leu Lys Ser Leu Thr Lys His Leu Pro 
                165                 170                 175     


Pro Leu Val Gly Arg Phe Val Pro Phe Ala Ala Val Ala Ala Ala Asn 
            180                 185                 190         


Cys Ile Asn Ile Pro Leu Met Arg Gln Arg Glu Leu Gln Val Gly Ile 
        195                 200                 205             


Pro Val Ala Asp Glu Ala Gly Gln Arg Leu Gly Tyr Ser Val Thr Ala 
    210                 215                 220                 


Ala Lys Gln Gly Ile Phe Gln Val Val Ile Ser Arg Ile Cys Met Ala 
225                 230                 235                 240 


Ile Pro Ala Met Ala Ile Pro Pro Leu Ile Met Asp Thr Leu Glu Lys 
                245                 250                 255     


Lys Asp Phe Leu Lys Arg Arg Pro Trp Leu Gly Ala Pro Leu Gln Val 
            260                 265                 270         


Gly Leu Val Gly Phe Cys Leu Val Phe Ala Thr Pro Leu Cys Cys Ala 
        275                 280                 285             


Leu Phe Pro Gln Lys Ser Ser Ile His Ile Ser Asn Leu Glu Pro Glu 
    290                 295                 300                 


Leu Arg Ala Gln Ile His Glu Gln Asn Pro Ser Val Glu Val Val Tyr 
305                 310                 315                 320 


Tyr Asn Lys Gly Leu 
                325 


<210>  5210
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  5210

Met Thr Pro Thr Asp Phe Thr Ser Pro Ile Pro Asn Met Ala Asp Asp 
1               5                   10                  15      


Tyr Gly Ser Glu Ser Thr Ser Ser Met Glu Asp Tyr Val Asn Phe Asn 
            20                  25                  30          


Phe Thr Asp Phe Tyr Cys Glu Lys Asn Asn Val Arg Gln Phe Ala Ser 
        35                  40                  45              


His Phe Leu Pro Pro Leu Tyr Trp Leu Val Phe Ile Val Gly Ala Leu 
    50                  55                  60                  


Gly Asn Ser Leu Val Ile Leu Val Tyr Trp Tyr Cys Thr Arg Val Lys 
65                  70                  75                  80  


Thr Met Thr Asp Met Phe Leu Leu Asn Leu Ala Ile Ala Asp Leu Leu 
                85                  90                  95      


Phe Leu Val Thr Leu Pro Phe Trp Ala Ile Ala Ala Ala Asp Gln Trp 
            100                 105                 110         


Lys Phe Gln Thr Phe Met Cys Lys Val Val Asn Ser Met Tyr Lys Met 
        115                 120                 125             


Asn Phe Tyr Ser Cys Val Leu Leu Ile Met Cys Ile Ser Val Asp Arg 
    130                 135                 140                 


Tyr Ile Ala Ile Ala Gln Ala Met Arg Ala His Thr Trp Arg Glu Lys 
145                 150                 155                 160 


Arg Leu Leu Tyr Ser Lys Met Val Cys Phe Thr Ile Trp Val Leu Ala 
                165                 170                 175     


Ala Ala Leu Cys Ile Pro Glu Ile Leu Tyr Ser Gln Ile Lys Glu Glu 
            180                 185                 190         


Ser Gly Ile Ala Ile Cys Thr Met Val Tyr Pro Ser Asp Glu Ser Thr 
        195                 200                 205             


Lys Leu Lys Ser Ala Val Leu Thr Leu Lys Val Ile Leu Gly Phe Phe 
    210                 215                 220                 


Leu Pro Phe Val Val Met Ala Cys Cys Tyr Thr Ile Ile Ile His Thr 
225                 230                 235                 240 


Leu Ile Gln Ala Lys Lys Ser Ser Lys His Lys Ala Leu Lys Val Thr 
                245                 250                 255     


Ile Thr Val Leu Thr Val Phe Val Leu Ser Gln Phe Pro Tyr Asn Cys 
            260                 265                 270         


Ile Leu Leu Val Gln Thr Ile Asp Ala Tyr Ala Met Phe Ile Ser Asn 
        275                 280                 285             


Cys Ala Val Ser Thr Asn Ile Asp Ile Cys Phe Gln Val Thr Gln Thr 
    290                 295                 300                 


Ile Ala Phe Phe His Ser Cys Leu Asn Pro Val Leu Tyr Val Phe Val 
305                 310                 315                 320 


Gly Glu Arg Phe Arg Arg Asp Leu Val Lys Thr Leu Lys Asn Leu Gly 
                325                 330                 335     


Cys Ile Ser Gln Ala Gln Trp Val Ser Phe Thr Arg Arg Glu Gly Ser 
            340                 345                 350         


Leu Lys Leu Ser Ser Met Leu Leu Glu Thr Thr Ser Gly Ala Leu Ser 
        355                 360                 365             


Leu 
    


<210>  5211
<211>  503
<212>  PRT
<213>  Homo sapiens

<400>  5211

Met Val Leu Glu Met Leu Asn Pro Ile His Tyr Asn Ile Thr Ser Ile 
1               5                   10                  15      


Val Pro Glu Ala Met Pro Ala Ala Thr Met Pro Val Leu Leu Leu Thr 
            20                  25                  30          


Gly Leu Phe Leu Leu Val Trp Asn Tyr Glu Gly Thr Ser Ser Ile Pro 
        35                  40                  45              


Gly Pro Gly Tyr Cys Met Gly Ile Gly Pro Leu Ile Ser His Gly Arg 
    50                  55                  60                  


Phe Leu Trp Met Gly Ile Gly Ser Ala Cys Asn Tyr Tyr Asn Arg Val 
65                  70                  75                  80  


Tyr Gly Glu Phe Met Arg Val Trp Ile Ser Gly Glu Glu Thr Leu Ile 
                85                  90                  95      


Ile Ser Lys Ser Ser Ser Met Phe His Ile Met Lys His Asn His Tyr 
            100                 105                 110         


Ser Ser Arg Phe Gly Ser Lys Leu Gly Leu Gln Cys Ile Gly Met His 
        115                 120                 125             


Glu Lys Gly Ile Ile Phe Asn Asn Asn Pro Glu Leu Trp Lys Thr Thr 
    130                 135                 140                 


Arg Pro Phe Phe Met Lys Ala Leu Ser Gly Pro Gly Leu Val Arg Met 
145                 150                 155                 160 


Val Thr Val Cys Ala Glu Ser Leu Lys Thr His Leu Asp Arg Leu Glu 
                165                 170                 175     


Glu Val Thr Asn Glu Ser Gly Tyr Val Asp Val Leu Thr Leu Leu Arg 
            180                 185                 190         


Arg Val Met Leu Asp Thr Ser Asn Thr Leu Phe Leu Arg Ile Pro Leu 
        195                 200                 205             


Asp Glu Ser Ala Ile Val Val Lys Ile Gln Gly Tyr Phe Asp Ala Trp 
    210                 215                 220                 


Gln Ala Leu Leu Ile Lys Pro Asp Ile Phe Phe Lys Ile Ser Trp Leu 
225                 230                 235                 240 


Tyr Lys Lys Tyr Glu Lys Ser Val Lys Asp Leu Lys Asp Ala Ile Glu 
                245                 250                 255     


Val Leu Ile Ala Glu Lys Arg Arg Arg Ile Ser Thr Glu Glu Lys Leu 
            260                 265                 270         


Glu Glu Cys Met Asp Phe Ala Thr Glu Leu Ile Leu Ala Glu Lys Arg 
        275                 280                 285             


Gly Asp Leu Thr Arg Glu Asn Val Asn Gln Cys Ile Leu Glu Met Leu 
    290                 295                 300                 


Ile Ala Ala Pro Asp Thr Met Ser Val Ser Leu Phe Phe Met Leu Phe 
305                 310                 315                 320 


Leu Ile Ala Lys His Pro Asn Val Glu Glu Ala Ile Ile Lys Glu Ile 
                325                 330                 335     


Gln Thr Val Ile Gly Glu Arg Asp Ile Lys Ile Asp Asp Ile Gln Lys 
            340                 345                 350         


Leu Lys Val Met Glu Asn Phe Ile Tyr Glu Ser Met Arg Tyr Gln Pro 
        355                 360                 365             


Val Val Asp Leu Val Met Arg Lys Ala Leu Glu Asp Asp Val Ile Asp 
    370                 375                 380                 


Gly Tyr Pro Val Lys Lys Gly Thr Asn Ile Ile Leu Asn Ile Gly Arg 
385                 390                 395                 400 


Met His Arg Leu Glu Phe Phe Pro Lys Pro Asn Glu Phe Thr Leu Glu 
                405                 410                 415     


Asn Phe Ala Lys Asn Val Pro Tyr Arg Tyr Phe Gln Pro Phe Gly Phe 
            420                 425                 430         


Gly Pro Arg Gly Cys Ala Gly Lys Tyr Ile Ala Met Val Met Met Lys 
        435                 440                 445             


Ala Ile Leu Val Thr Leu Leu Arg Arg Phe His Val Lys Thr Leu Gln 
    450                 455                 460                 


Gly Gln Cys Val Glu Ser Ile Gln Lys Ile His Asp Leu Ser Leu His 
465                 470                 475                 480 


Pro Asp Glu Thr Lys Asn Met Leu Glu Met Ile Phe Thr Pro Arg Asn 
                485                 490                 495     


Ser Asp Arg Cys Leu Glu His 
            500             


<210>  5212
<211>  651
<212>  PRT
<213>  Homo sapiens

<400>  5212

Met Gly Ser Trp Ala Leu Leu Trp Pro Pro Leu Leu Phe Thr Gly Leu 
1               5                   10                  15      


Leu Val Arg Pro Pro Gly Thr Met Ala Gln Ala Gln Tyr Cys Ser Val 
            20                  25                  30          


Asn Lys Asp Ile Phe Glu Val Glu Glu Asn Thr Asn Val Thr Glu Pro 
        35                  40                  45              


Leu Val Asp Ile His Val Pro Glu Gly Gln Glu Val Thr Leu Gly Ala 
    50                  55                  60                  


Leu Ser Thr Pro Phe Ala Phe Arg Ile Gln Gly Asn Gln Leu Phe Leu 
65                  70                  75                  80  


Asn Val Thr Pro Asp Tyr Glu Glu Lys Ser Leu Leu Glu Ala Gln Leu 
                85                  90                  95      


Leu Cys Gln Ser Gly Gly Thr Leu Val Thr Gln Leu Arg Val Phe Val 
            100                 105                 110         


Ser Val Leu Asp Val Asn Asp Asn Ala Pro Glu Phe Pro Phe Lys Thr 
        115                 120                 125             


Lys Glu Ile Arg Val Glu Glu Asp Thr Lys Val Asn Ser Thr Val Ile 
    130                 135                 140                 


Pro Glu Thr Gln Leu Gln Ala Glu Asp Arg Asp Lys Asp Asp Ile Leu 
145                 150                 155                 160 


Phe Tyr Thr Leu Gln Glu Met Thr Ala Gly Ala Ser Asp Tyr Phe Ser 
                165                 170                 175     


Leu Val Ser Val Asn Arg Pro Ala Leu Arg Leu Asp Arg Pro Leu Asp 
            180                 185                 190         


Phe Tyr Glu Arg Pro Asn Met Thr Phe Trp Leu Leu Val Arg Asp Thr 
        195                 200                 205             


Pro Gly Glu Asn Val Glu Pro Ser His Thr Ala Thr Ala Thr Leu Val 
    210                 215                 220                 


Leu Asn Val Val Pro Ala Asp Leu Arg Pro Pro Trp Phe Leu Pro Cys 
225                 230                 235                 240 


Thr Phe Ser Asp Gly Tyr Val Cys Ile Gln Ala Gln Tyr His Gly Ala 
                245                 250                 255     


Val Pro Thr Gly His Ile Leu Pro Ser Pro Leu Val Leu Arg Pro Gly 
            260                 265                 270         


Pro Ile Tyr Ala Glu Asp Gly Asp Arg Gly Ile Asn Gln Pro Ile Ile 
        275                 280                 285             


Tyr Ser Ile Phe Arg Gly Asn Val Asn Gly Thr Phe Ile Ile His Pro 
    290                 295                 300                 


Asp Ser Gly Asn Leu Thr Val Ala Arg Ser Val Pro Ser Pro Met Thr 
305                 310                 315                 320 


Phe Leu Leu Leu Val Lys Gly Gln Gln Ala Asp Leu Ala Arg Tyr Ser 
                325                 330                 335     


Val Thr Gln Val Thr Val Glu Ala Val Ala Ala Ala Gly Ser Pro Pro 
            340                 345                 350         


Arg Phe Pro Gln Arg Leu Tyr Arg Gly Thr Val Ala Arg Gly Ala Gly 
        355                 360                 365             


Ala Gly Val Val Val Lys Asp Ala Ala Ala Pro Ser Gln Pro Leu Arg 
    370                 375                 380                 


Ile Gln Ala Gln Asp Pro Glu Phe Ser Asp Leu Asn Ser Ala Ile Thr 
385                 390                 395                 400 


Tyr Arg Ile Thr Asn His Ser His Phe Arg Met Glu Gly Glu Val Val 
                405                 410                 415     


Leu Thr Thr Thr Thr Leu Ala Gln Ala Gly Ala Phe Tyr Ala Glu Val 
            420                 425                 430         


Glu Ala His Asn Thr Val Thr Ser Gly Thr Ala Thr Thr Val Ile Glu 
        435                 440                 445             


Ile Gln Val Ser Glu Gln Glu Pro Pro Ser Thr Gly Gly Gly Pro Ser 
    450                 455                 460                 


Glu Asp Lys Arg Phe Ser Val Val Asp Met Ala Ala Leu Gly Gly Val 
465                 470                 475                 480 


Leu Gly Ala Leu Leu Leu Leu Ala Leu Leu Gly Leu Ala Val Leu Val 
                485                 490                 495     


His Lys His Tyr Gly Pro Arg Leu Lys Cys Cys Ser Gly Lys Ala Pro 
            500                 505                 510         


Glu Pro Gln Pro Gln Gly Phe Asp Asn Gln Ala Phe Leu Pro Asp His 
        515                 520                 525             


Lys Ala Asn Trp Ala Pro Val Pro Ser Pro Thr His Asp Pro Lys Pro 
    530                 535                 540                 


Ala Glu Ala Pro Met Pro Ala Glu Pro Ala Pro Pro Gly Pro Ala Ser 
545                 550                 555                 560 


Pro Gly Gly Ala Pro Glu Pro Pro Ala Ala Ala Arg Ala Gly Gly Ser 
                565                 570                 575     


Pro Thr Ala Val Arg Ser Ile Leu Thr Lys Glu Arg Arg Pro Glu Gly 
            580                 585                 590         


Gly Tyr Lys Ala Val Trp Phe Gly Glu Asp Ile Gly Thr Glu Ala Asp 
        595                 600                 605             


Val Val Val Leu Asn Ala Pro Thr Leu Asp Val Asp Gly Ala Ser Asp 
    610                 615                 620                 


Ser Gly Ser Gly Asp Glu Gly Glu Gly Ala Gly Arg Gly Gly Gly Pro 
625                 630                 635                 640 


Tyr Asp Ala Pro Gly Gly Asp Asp Ser Tyr Ile 
                645                 650     


<210>  5213
<211>  977
<212>  PRT
<213>  Homo sapiens

<400>  5213

Met Leu Leu Trp Val Ile Leu Leu Val Leu Ala Pro Val Ser Gly Gln 
1               5                   10                  15      


Phe Ala Arg Thr Pro Arg Pro Ile Ile Phe Leu Gln Pro Pro Trp Thr 
            20                  25                  30          


Thr Val Phe Gln Gly Glu Arg Val Thr Leu Thr Cys Lys Gly Phe Arg 
        35                  40                  45              


Phe Tyr Ser Pro Gln Lys Thr Lys Trp Tyr His Arg Tyr Leu Gly Lys 
    50                  55                  60                  


Glu Ile Leu Arg Glu Thr Pro Asp Asn Ile Leu Glu Val Gln Glu Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Ala Gln Gly Ser Pro Leu Ser Ser Pro Val 
                85                  90                  95      


His Leu Asp Phe Ser Ser Ala Ser Leu Ile Leu Gln Ala Pro Leu Ser 
            100                 105                 110         


Val Phe Glu Gly Asp Ser Val Val Leu Arg Cys Arg Ala Lys Ala Glu 
        115                 120                 125             


Val Thr Leu Asn Asn Thr Ile Tyr Lys Asn Asp Asn Val Leu Ala Phe 
    130                 135                 140                 


Leu Asn Lys Arg Thr Asp Phe His Ile Pro His Ala Cys Leu Lys Asp 
145                 150                 155                 160 


Asn Gly Ala Tyr Arg Cys Thr Gly Tyr Lys Glu Ser Cys Cys Pro Val 
                165                 170                 175     


Ser Ser Asn Thr Val Lys Ile Gln Val Gln Glu Pro Phe Thr Arg Pro 
            180                 185                 190         


Val Leu Arg Ala Ser Ser Phe Gln Pro Ile Ser Gly Asn Pro Val Thr 
        195                 200                 205             


Leu Thr Cys Glu Thr Gln Leu Ser Leu Glu Arg Ser Asp Val Pro Leu 
    210                 215                 220                 


Arg Phe Arg Phe Phe Arg Asp Asp Gln Thr Leu Gly Leu Gly Trp Ser 
225                 230                 235                 240 


Leu Ser Pro Asn Phe Gln Ile Thr Ala Met Trp Ser Lys Asp Ser Gly 
                245                 250                 255     


Phe Tyr Trp Cys Lys Ala Ala Thr Met Pro Tyr Ser Val Ile Ser Asp 
            260                 265                 270         


Ser Pro Arg Ser Trp Ile Gln Val Gln Ile Pro Ala Ser His Pro Val 
        275                 280                 285             


Leu Thr Leu Ser Pro Glu Lys Ala Leu Asn Phe Glu Gly Thr Lys Val 
    290                 295                 300                 


Thr Leu His Cys Glu Thr Gln Glu Asp Ser Leu Arg Thr Leu Tyr Arg 
305                 310                 315                 320 


Phe Tyr His Glu Gly Val Pro Leu Arg His Lys Ser Val Arg Cys Glu 
                325                 330                 335     


Arg Gly Ala Ser Ile Ser Phe Ser Leu Thr Thr Glu Asn Ser Gly Asn 
            340                 345                 350         


Tyr Tyr Cys Thr Ala Asp Asn Gly Leu Gly Ala Lys Pro Ser Lys Ala 
        355                 360                 365             


Val Ser Leu Ser Val Thr Val Pro Val Ser His Pro Val Leu Asn Leu 
    370                 375                 380                 


Ser Ser Pro Glu Asp Leu Ile Phe Glu Gly Ala Lys Val Thr Leu His 
385                 390                 395                 400 


Cys Glu Ala Gln Arg Gly Ser Leu Pro Ile Leu Tyr Gln Phe His His 
                405                 410                 415     


Glu Gly Ala Ala Leu Glu Arg Arg Ser Ala Asn Ser Ala Gly Gly Val 
            420                 425                 430         


Ala Ile Ser Phe Ser Leu Thr Ala Glu His Ser Gly Asn Tyr Tyr Cys 
        435                 440                 445             


Thr Ala Asp Asn Gly Phe Gly Pro Gln Arg Ser Lys Ala Val Ser Leu 
    450                 455                 460                 


Ser Val Thr Val Pro Val Ser His Pro Val Leu Thr Leu Ser Ser Ala 
465                 470                 475                 480 


Glu Ala Leu Thr Phe Glu Gly Ala Thr Val Thr Leu His Cys Glu Val 
                485                 490                 495     


Gln Arg Gly Ser Pro Gln Ile Leu Tyr Gln Phe Tyr His Glu Asp Met 
            500                 505                 510         


Pro Leu Trp Ser Ser Ser Thr Pro Ser Val Gly Arg Val Ser Phe Ser 
        515                 520                 525             


Phe Ser Leu Thr Glu Gly His Ser Gly Asn Tyr Tyr Cys Thr Ala Asp 
    530                 535                 540                 


Asn Gly Phe Gly Pro Gln Arg Ser Glu Val Val Ser Leu Phe Val Thr 
545                 550                 555                 560 


Val Pro Val Ser Arg Pro Ile Leu Thr Leu Arg Val Pro Arg Ala Gln 
                565                 570                 575     


Ala Val Val Gly Asp Leu Leu Glu Leu His Cys Glu Ala Pro Arg Gly 
            580                 585                 590         


Ser Pro Pro Ile Leu Tyr Trp Phe Tyr His Glu Asp Val Thr Leu Gly 
        595                 600                 605             


Ser Ser Ser Ala Pro Ser Gly Gly Glu Ala Ser Phe Asn Leu Ser Leu 
    610                 615                 620                 


Thr Ala Glu His Ser Gly Asn Tyr Ser Cys Glu Ala Asn Asn Gly Leu 
625                 630                 635                 640 


Val Ala Gln His Ser Asp Thr Ile Ser Leu Ser Val Ile Val Pro Val 
                645                 650                 655     


Ser Arg Pro Ile Leu Thr Phe Arg Ala Pro Arg Ala Gln Ala Val Val 
            660                 665                 670         


Gly Asp Leu Leu Glu Leu His Cys Glu Ala Leu Arg Gly Ser Ser Pro 
        675                 680                 685             


Ile Leu Tyr Trp Phe Tyr His Glu Asp Val Thr Leu Gly Lys Ile Ser 
    690                 695                 700                 


Ala Pro Ser Gly Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Thr Glu 
705                 710                 715                 720 


His Ser Gly Ile Tyr Ser Cys Glu Ala Asp Asn Gly Leu Glu Ala Gln 
                725                 730                 735     


Arg Ser Glu Met Val Thr Leu Lys Val Ala Val Pro Val Ser Arg Pro 
            740                 745                 750         


Val Leu Thr Leu Arg Ala Pro Gly Thr His Ala Ala Val Gly Asp Leu 
        755                 760                 765             


Leu Glu Leu His Cys Glu Ala Leu Arg Gly Ser Pro Leu Ile Leu Tyr 
    770                 775                 780                 


Arg Phe Phe His Glu Asp Val Thr Leu Gly Asn Arg Ser Ser Pro Ser 
785                 790                 795                 800 


Gly Gly Ala Ser Leu Asn Leu Ser Leu Thr Ala Glu His Ser Gly Asn 
                805                 810                 815     


Tyr Ser Cys Glu Ala Asp Asn Gly Leu Gly Ala Gln Arg Ser Glu Thr 
            820                 825                 830         


Val Thr Leu Tyr Ile Thr Gly Leu Thr Ala Asn Arg Ser Gly Pro Phe 
        835                 840                 845             


Ala Thr Gly Val Ala Gly Gly Leu Leu Ser Ile Ala Gly Leu Ala Ala 
    850                 855                 860                 


Gly Ala Leu Leu Leu Tyr Cys Trp Leu Ser Arg Lys Ala Gly Arg Lys 
865                 870                 875                 880 


Pro Ala Ser Asp Pro Ala Arg Ser Pro Ser Asp Ser Asp Ser Gln Glu 
                885                 890                 895     


Pro Thr Tyr His Asn Val Pro Ala Trp Glu Glu Leu Gln Pro Val Tyr 
            900                 905                 910         


Thr Asn Ala Asn Pro Arg Gly Glu Asn Val Val Tyr Ser Glu Val Arg 
        915                 920                 925             


Ile Ile Gln Glu Lys Lys Lys His Ala Val Ala Ser Asp Pro Arg His 
    930                 935                 940                 


Leu Arg Asn Lys Gly Ser Pro Ile Ile Tyr Ser Glu Val Lys Val Ala 
945                 950                 955                 960 


Ser Thr Pro Val Ser Gly Ser Leu Phe Leu Ala Ser Ser Ala Pro His 
                965                 970                 975     


Arg 
    


<210>  5214
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  5214

Met Leu Leu Trp Ala Ser Leu Leu Ala Phe Ala Pro Val Cys Gly Gln 
1               5                   10                  15      


Ser Ala Ala Ala His Lys Pro Val Ile Ser Val His Pro Pro Trp Thr 
            20                  25                  30          


Thr Phe Phe Lys Gly Glu Arg Val Thr Leu Thr Cys Asn Gly Phe Gln 
        35                  40                  45              


Phe Tyr Ala Thr Glu Lys Thr Thr Trp Tyr His Arg His Tyr Trp Gly 
    50                  55                  60                  


Glu Lys Leu Thr Leu Thr Pro Gly Asn Thr Leu Glu Val Arg Glu Ser 
65                  70                  75                  80  


Gly Leu Tyr Arg Cys Gln Ala Arg Gly Ser Pro Arg Ser Asn Pro Val 
                85                  90                  95      


Arg Leu Leu Phe Ser Ser Asp Ser Leu Ile Leu Gln Ala Pro Tyr Ser 
            100                 105                 110         


Val Phe Glu Gly Asp Thr Leu Val Leu Arg Cys His Arg Arg Arg Lys 
        115                 120                 125             


Glu Lys Leu Thr Ala Val Lys Tyr Thr Trp Asn Gly Asn Ile Leu Ser 
    130                 135                 140                 


Ile Ser Asn Lys Ser Trp Asp Leu Leu Ile Pro Gln Ala Ser Ser Asn 
145                 150                 155                 160 


Asn Asn Gly Asn Tyr Arg Cys Ile Gly Tyr Gly Asp Glu Asn Asp Val 
                165                 170                 175     


Phe Arg Ser Asn Phe Lys Ile Ile Lys Ile Gln Glu Leu Phe Pro His 
            180                 185                 190         


Pro Glu Leu Lys Ala Thr Asp Ser Gln Pro Thr Glu Gly Asn Ser Val 
        195                 200                 205             


Asn Leu Ser Cys Glu Thr Gln Leu Pro Pro Glu Arg Ser Asp Thr Pro 
    210                 215                 220                 


Leu His Phe Asn Phe Phe Arg Asp Gly Glu Val Ile Leu Ser Asp Trp 
225                 230                 235                 240 


Ser Thr Tyr Pro Glu Leu Gln Leu Pro Thr Val Trp Arg Glu Asn Ser 
                245                 250                 255     


Gly Ser Tyr Trp Cys Gly Ala Glu Thr Val Arg Gly Asn Ile His Lys 
            260                 265                 270         


His Ser Pro Ser Leu Gln Ile His Val Gln Arg Ile Pro Val Ser Gly 
        275                 280                 285             


Val Leu Leu Glu Thr Gln Pro Ser Gly Gly Gln Ala Val Glu Gly Glu 
    290                 295                 300                 


Met Leu Val Leu Val Cys Ser Val Ala Glu Gly Thr Gly Asp Thr Thr 
305                 310                 315                 320 


Phe Ser Trp His Arg Glu Asp Met Gln Glu Ser Leu Gly Arg Lys Thr 
                325                 330                 335     


Gln Arg Ser Leu Arg Ala Glu Leu Glu Leu Pro Ala Ile Arg Gln Ser 
            340                 345                 350         


His Ala Gly Gly Tyr Tyr Cys Thr Ala Asp Asn Ser Tyr Gly Pro Val 
        355                 360                 365             


Gln Ser Met Val Leu Asn Val Thr Val Arg Glu Thr Pro Gly Asn Arg 
    370                 375                 380                 


Asp Gly Leu Val Ala Ala Gly Ala Thr Gly Gly Leu Leu Ser Ala Leu 
385                 390                 395                 400 


Leu Leu Ala Val Ala Leu Leu Phe His Cys Trp Arg Arg Arg Lys Ser 
                405                 410                 415     


Gly Val Gly Phe Leu Gly Asp Glu Thr Arg Leu Pro Pro Ala Pro Gly 
            420                 425                 430         


Pro Gly Glu Ser Ser His Ser Ile Cys Pro Ala Gln Val Glu Leu Gln 
        435                 440                 445             


Ser Leu Tyr Val Asp Val His Pro Lys Lys Gly Asp Leu Val Tyr Ser 
    450                 455                 460                 


Glu Ile Gln Thr Thr Gln Leu Gly Glu Glu Glu Glu Ala Asn Thr Ser 
465                 470                 475                 480 


Arg Thr Leu Leu Glu Asp Lys Asp Val Ser Val Val Tyr Ser Glu Val 
                485                 490                 495     


Lys Thr Gln His Pro Asp Asn Ser Ala Gly Lys Ile Ser Ser Lys Asp 
            500                 505                 510         


Glu Glu Ser 
        515 


<210>  5215
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  5215

Met Ala Lys Met Glu Leu Ser Lys Ala Phe Ser Gly Gln Arg Thr Leu 
1               5                   10                  15      


Leu Ser Ala Ile Leu Ser Met Leu Ser Leu Ser Phe Ser Thr Thr Ser 
            20                  25                  30          


Leu Leu Ser Asn Tyr Trp Phe Val Gly Thr Gln Lys Val Pro Lys Pro 
        35                  40                  45              


Leu Cys Glu Lys Gly Leu Ala Ala Lys Cys Phe Asp Met Pro Val Ser 
    50                  55                  60                  


Leu Asp Gly Asp Thr Asn Thr Ser Thr Gln Glu Val Val Gln Tyr Asn 
65                  70                  75                  80  


Trp Glu Thr Gly Asp Asp Arg Phe Ser Phe Arg Ser Phe Arg Ser Gly 
                85                  90                  95      


Met Trp Leu Ser Cys Glu Glu Thr Val Glu Glu Pro Gly Glu Arg Cys 
            100                 105                 110         


Arg Ser Phe Ile Glu Leu Thr Pro Pro Ala Lys Arg Gly Glu Lys Gly 
        115                 120                 125             


Leu Leu Glu Phe Ala Thr Leu Gln Gly Pro Cys His Pro Thr Leu Arg 
    130                 135                 140                 


Phe Gly Gly Lys Arg Leu Met Glu Lys Ala Ser Leu Pro Ser Pro Pro 
145                 150                 155                 160 


Leu Gly Leu Cys Gly Lys Asn Pro Met Val Ile Pro Gly Asn Ala Asp 
                165                 170                 175     


His Leu His Arg Thr Ser Ile His Gln Leu Pro Pro Ala Thr Asn Arg 
            180                 185                 190         


Leu Ala Thr His Trp Glu Pro Cys Leu Trp Ala Gln Thr Glu Arg Leu 
        195                 200                 205             


Cys Cys Cys Phe Leu Cys Pro Val Arg Ser Pro Gly Asp Gly Gly Pro 
    210                 215                 220                 


His Asp Val Phe Thr Ser Leu Pro Ser Asp Cys Gln Leu Gly Ser Arg 
225                 230                 235                 240 


Arg Leu Glu Thr Thr Cys Leu Glu Leu Trp Leu Gly Leu Leu His Gly 
                245                 250                 255     


Leu Ala Leu Leu His Leu Leu His Gly Val Gly Cys His His Leu Gln 
            260                 265                 270         


His Val His Gln Asp Gly Ala Gly Val Gln Val Gln Ala 
        275                 280                 285 


<210>  5216
<211>  315
<212>  PRT
<213>  Homo sapiens

<400>  5216

Met His Arg Glu Pro Ala Lys Lys Lys Ala Glu Lys Arg Leu Phe Asp 
1               5                   10                  15      


Ala Ser Ser Phe Gly Lys Asp Leu Leu Ala Gly Gly Val Ala Ala Ala 
            20                  25                  30          


Val Ser Lys Thr Ala Val Ala Pro Ile Glu Arg Val Lys Leu Leu Leu 
        35                  40                  45              


Gln Val Gln Ala Ser Ser Lys Gln Ile Ser Pro Glu Ala Arg Tyr Lys 
    50                  55                  60                  


Gly Met Val Asp Cys Leu Val Arg Ile Pro Arg Glu Gln Gly Phe Phe 
65                  70                  75                  80  


Ser Phe Trp Arg Gly Asn Leu Ala Asn Val Ile Arg Tyr Phe Pro Thr 
                85                  90                  95      


Gln Ala Leu Asn Phe Ala Phe Lys Asp Lys Tyr Lys Gln Leu Phe Met 
            100                 105                 110         


Ser Gly Val Asn Lys Glu Lys Gln Phe Trp Arg Trp Phe Leu Ala Asn 
        115                 120                 125             


Leu Ala Ser Gly Gly Ala Ala Gly Ala Thr Ser Leu Cys Val Val Tyr 
    130                 135                 140                 


Pro Leu Asp Phe Ala Arg Thr Arg Leu Gly Val Asp Ile Gly Lys Gly 
145                 150                 155                 160 


Pro Glu Glu Arg Gln Phe Lys Gly Leu Gly Asp Cys Ile Met Lys Ile 
                165                 170                 175     


Ala Lys Ser Asp Gly Ile Ala Gly Leu Tyr Gln Gly Phe Gly Val Ser 
            180                 185                 190         


Val Gln Gly Ile Ile Val Tyr Arg Ala Ser Tyr Phe Gly Ala Tyr Asp 
        195                 200                 205             


Thr Val Lys Gly Leu Leu Pro Lys Pro Lys Lys Thr Pro Phe Leu Val 
    210                 215                 220                 


Ser Phe Phe Ile Ala Gln Val Val Thr Thr Cys Ser Gly Ile Leu Ser 
225                 230                 235                 240 


Tyr Pro Phe Asp Thr Val Arg Arg Arg Met Met Met Gln Ser Gly Glu 
                245                 250                 255     


Ala Lys Arg Gln Tyr Lys Gly Thr Leu Asp Cys Phe Val Lys Ile Tyr 
            260                 265                 270         


Gln His Glu Gly Ile Ser Ser Phe Phe Arg Gly Ala Phe Ser Asn Val 
        275                 280                 285             


Leu Arg Gly Thr Gly Gly Ala Leu Val Leu Val Leu Tyr Asp Lys Ile 
    290                 295                 300                 


Lys Glu Phe Phe His Ile Asp Ile Gly Gly Arg 
305                 310                 315 


<210>  5217
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  5217

Met Ala Ala Val Val Ala Lys Arg Glu Gly Pro Pro Phe Ile Ser Glu 
1               5                   10                  15      


Ala Ala Val Arg Gly Asn Ala Ala Val Leu Asp Tyr Cys Arg Thr Ser 
            20                  25                  30          


Val Ser Ala Leu Ser Gly Ala Thr Ala Gly Ile Leu Gly Leu Thr Gly 
        35                  40                  45              


Leu Tyr Gly Phe Ile Phe Tyr Leu Leu Ala Ser Val Leu Leu Ser Leu 
    50                  55                  60                  


Leu Leu Ile Leu Lys Ala Gly Arg Arg Trp Asn Lys Tyr Phe Lys Ser 
65                  70                  75                  80  


Arg Arg Pro Leu Phe Thr Gly Gly Leu Ile Gly Gly Leu Phe Thr Tyr 
                85                  90                  95      


Val Leu Phe Trp Thr Phe Leu Tyr Gly Met Val His Val Tyr 
            100                 105                 110 


<210>  5218
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  5218

Met Thr Ala Ala Val Phe Phe Gly Cys Ala Phe Ile Ala Phe Gly Pro 
1               5                   10                  15      


Ala Leu Ala Leu Tyr Val Phe Thr Ile Ala Thr Glu Pro Leu Arg Ile 
            20                  25                  30          


Ile Phe Leu Ile Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Ile 
        35                  40                  45              


Ser Ser Leu Val Trp Phe Met Ala Arg Val Ile Ile Asp Asn Lys Asp 
    50                  55                  60                  


Gly Pro Thr Gln Lys Tyr Leu Leu Ile Phe Gly Ala Phe Val Ser Val 
65                  70                  75                  80  


Tyr Ile Gln Glu Met Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Ser Glu Gly Leu Lys Ser Ile Asn Pro Gly Glu Thr Ala Pro Ser 
            100                 105                 110         


Met Arg Leu Leu Ala Tyr Val Ser Gly Leu Gly Phe Gly Ile Met Ser 
        115                 120                 125             


Gly Val Phe Ser Phe Val Asn Thr Leu Ser Asp Ser Leu Gly Pro Gly 
    130                 135                 140                 


Thr Val Gly Ile His Gly Asp Ser Pro Gln Phe Phe Leu Tyr Ser Ala 
145                 150                 155                 160 


Phe Met Thr Leu Val Ile Ile Leu Leu His Val Phe Trp Gly Ile Val 
                165                 170                 175     


Phe Phe Asp Gly Cys Glu Lys Lys Lys Trp Gly Ile Leu Leu Ile Val 
            180                 185                 190         


Leu Leu Thr His Leu Leu Val Ser Ala Gln Thr Phe Ile Ser Ser Tyr 
        195                 200                 205             


Tyr Gly Ile Asn Leu Ala Ser Ala Phe Ile Ile Leu Val Leu Met Gly 
    210                 215                 220                 


Thr Trp Ala Phe Leu Ala Ala Gly Gly Ser Cys Arg Ser Leu Lys Leu 
225                 230                 235                 240 


Cys Leu Leu Cys Gln Asp Lys Asn Phe Leu Leu Tyr Asn Gln Arg Ser 
                245                 250                 255     


Arg 
    


<210>  5219
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  5219

Met Ala Leu Leu Arg Lys Ile Asn Gln Val Leu Leu Phe Leu Leu Ile 
1               5                   10                  15      


Val Thr Leu Cys Val Ile Leu Tyr Lys Lys Val His Lys Gly Thr Val 
            20                  25                  30          


Pro Lys Asn Asp Ala Asp Asp Glu Ser Glu Thr Pro Glu Glu Leu Glu 
        35                  40                  45              


Glu Glu Ile Pro Val Val Ile Cys Ala Ala Ala Gly Arg Met Gly Ala 
    50                  55                  60                  


Thr Met Ala Ala Ile Asn Ser Ile Tyr Ser Asn Thr Asp Ala Asn Ile 
65                  70                  75                  80  


Leu Phe Tyr Val Val Gly Leu Arg Asn Thr Leu Thr Arg Ile Arg Lys 
                85                  90                  95      


Trp Ile Glu His Ser Lys Leu Arg Glu Ile Asn Phe Lys Ile Val Glu 
            100                 105                 110         


Phe Asn Pro Met Val Leu Lys Gly Lys Ile Arg Pro Asp Ser Ser Arg 
        115                 120                 125             


Pro Glu Leu Leu Gln Pro Leu Asn Phe Val Arg Phe Tyr Leu Pro Leu 
    130                 135                 140                 


Leu Ile His Gln His Glu Lys Val Ile Tyr Leu Asp Asp Asp Val Ile 
145                 150                 155                 160 


Val Gln Gly Asp Ile Gln Glu Leu Tyr Asp Thr Thr Leu Ala Leu Gly 
                165                 170                 175     


His Ala Ala Ala Phe Ser Asp Asp Cys Asp Leu Pro Ser Ala Gln Asp 
            180                 185                 190         


Ile Asn Arg Leu Val Gly Leu Gln Asn Thr Tyr Met Gly Tyr Leu Asp 
        195                 200                 205             


Tyr Arg Lys Lys Ala Ile Lys Asp Leu Gly Ile Ser Pro Ser Thr Cys 
    210                 215                 220                 


Ser Phe Asn Pro Gly Val Ile Val Ala Asn Met Thr Glu Trp Lys His 
225                 230                 235                 240 


Gln Arg Ile Thr Lys Gln Leu Glu Lys Trp Met Gln Lys Asn Val Glu 
                245                 250                 255     


Glu Asn Leu Tyr Ser Ser Ser Leu Gly Gly Gly Val Ala Thr Ser Pro 
            260                 265                 270         


Met Leu Ile Val Phe His Gly Lys Tyr Ser Thr Ile Asn Pro Leu Trp 
        275                 280                 285             


His Ile Arg His Leu Gly Trp Asn Pro Asp Ala Arg Tyr Ser Glu His 
    290                 295                 300                 


Phe Leu Gln Glu Ala Lys Leu Leu His Trp Asn Gly Arg His Lys Pro 
305                 310                 315                 320 


Trp Asp Phe Pro Ser Val His Asn Asp Leu Trp Glu Ser Trp Phe Val 
                325                 330                 335     


Pro Asp Pro Ala Gly Ile Phe Lys Leu Asn His His Ser 
            340                 345                 


<210>  5220
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  5220

Met Gly Leu Ala Met Glu His Gly Gly Ser Tyr Ala Arg Ala Gly Gly 
1               5                   10                  15      


Ser Ser Arg Gly Cys Trp Tyr Tyr Leu Arg Tyr Phe Phe Leu Phe Val 
            20                  25                  30          


Ser Leu Ile Gln Phe Leu Ile Ile Leu Gly Leu Val Leu Phe Met Val 
        35                  40                  45              


Tyr Gly Asn Val His Val Ser Thr Glu Ser Asn Leu Gln Ala Thr Glu 
    50                  55                  60                  


Arg Arg Ala Glu Gly Leu Tyr Ser Gln Leu Leu Gly Leu Thr Ala Ser 
65                  70                  75                  80  


Gln Ser Asn Leu Thr Lys Glu Leu Asn Phe Thr Thr Arg Ala Lys Asp 
                85                  90                  95      


Ala Ile Met Gln Met Trp Leu Asn Ala Arg Arg Asp Leu Asp Arg Ile 
            100                 105                 110         


Asn Ala Ser Phe Arg Gln Cys Gln Gly Asp Arg Val Ile Tyr Thr Asn 
        115                 120                 125             


Asn Gln Arg Tyr Met Ala Ala Ile Ile Leu Ser Glu Lys Gln Cys Arg 
    130                 135                 140                 


Asp Gln Phe Lys Asp Met Asn Lys Ser Cys Asp Ala Leu Leu Phe Met 
145                 150                 155                 160 


Leu Asn Gln Lys Val Lys Thr Leu Glu Val Glu Ile Ala Lys Glu Lys 
                165                 170                 175     


Thr Ile Cys Thr Lys Asp Lys Glu Ser Val Leu Leu Asn Lys Arg Val 
            180                 185                 190         


Ala Glu Glu Gln Leu Val Glu Cys Val Lys Thr Arg Glu Leu Gln His 
        195                 200                 205             


Gln Glu Arg Gln Leu Ala Lys Glu Gln Leu Gln Lys Val Gln Ala Leu 
    210                 215                 220                 


Cys Leu Pro Leu Asp Lys Asp Lys Phe Glu Met Asp Leu Arg Asn Leu 
225                 230                 235                 240 


Trp Arg Asp Ser Ile Ile Pro Arg Ser Leu Asp Asn Leu Gly Tyr Asn 
                245                 250                 255     


Leu Tyr His Pro Leu Gly Ser Glu Leu Ala Ser Ile Arg Arg Ala Cys 
            260                 265                 270         


Asp His Met Pro Ser Leu Met Ser Ser Lys Val Glu Glu Leu Ala Arg 
        275                 280                 285             


Ser Leu Arg Ala Asp Ile Glu Arg Val Ala Arg Glu Asn Ser Asp Leu 
    290                 295                 300                 


Gln Arg Gln Lys Leu Glu Ala Gln Gln Gly Leu Arg Ala Ser Gln Glu 
305                 310                 315                 320 


Ala Lys Gln Lys Val Glu Lys Glu Ala Gln Ala Arg Glu Ala Lys Leu 
                325                 330                 335     


Gln Ala Glu Cys Ser Arg Gln Thr Gln Leu Ala Leu Glu Glu Lys Ala 
            340                 345                 350         


Val Leu Arg Lys Glu Arg Asp Asn Leu Ala Lys Glu Leu Glu Glu Lys 
        355                 360                 365             


Lys Arg Glu Ala Glu Gln Leu Arg Met Glu Leu Ala Ile Arg Asn Ser 
    370                 375                 380                 


Ala Leu Asp Thr Cys Ile Lys Thr Lys Ser Gln Pro Met Met Pro Val 
385                 390                 395                 400 


Ser Arg Pro Met Gly Pro Val Pro Asn Pro Gln Pro Ile Asp Pro Ala 
                405                 410                 415     


Ser Leu Glu Glu Phe Lys Arg Lys Ile Leu Glu Ser Gln Arg Pro Pro 
            420                 425                 430         


Ala Gly Ile Pro Val Ala Pro Ser Ser Gly 
        435                 440         


<210>  5221
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  5221

Met Ser Gly Glu Ser Met Asn Phe Ser Asp Val Phe Asp Ser Ser Glu 
1               5                   10                  15      


Asp Tyr Phe Val Ser Val Asn Thr Ser Tyr Tyr Ser Val Asp Ser Glu 
            20                  25                  30          


Met Leu Leu Cys Ser Leu Gln Glu Val Arg Gln Phe Ser Arg Leu Phe 
        35                  40                  45              


Val Pro Ile Ala Tyr Ser Leu Ile Cys Val Phe Gly Leu Leu Gly Asn 
    50                  55                  60                  


Ile Leu Val Val Ile Thr Phe Ala Phe Tyr Lys Lys Ala Arg Ser Met 
65                  70                  75                  80  


Thr Asp Val Tyr Leu Leu Asn Met Ala Ile Ala Asp Ile Leu Phe Val 
                85                  90                  95      


Leu Thr Leu Pro Phe Trp Ala Val Ser His Ala Thr Gly Ala Trp Val 
            100                 105                 110         


Phe Ser Asn Ala Thr Cys Lys Leu Leu Lys Gly Ile Tyr Ala Ile Asn 
        115                 120                 125             


Phe Asn Cys Gly Met Leu Leu Leu Thr Cys Ile Ser Met Asp Arg Tyr 
    130                 135                 140                 


Ile Ala Ile Val Gln Ala Thr Lys Ser Phe Arg Leu Arg Ser Arg Thr 
145                 150                 155                 160 


Leu Pro Arg Ser Lys Ile Ile Cys Leu Val Val Trp Gly Leu Ser Val 
                165                 170                 175     


Ile Ile Ser Ser Ser Thr Phe Val Phe Asn Gln Lys Tyr Asn Thr Gln 
            180                 185                 190         


Gly Ser Asp Val Cys Glu Pro Lys Tyr Gln Thr Val Ser Glu Pro Ile 
        195                 200                 205             


Arg Trp Lys Leu Leu Met Leu Gly Leu Glu Leu Leu Phe Gly Phe Phe 
    210                 215                 220                 


Ile Pro Leu Met Phe Met Ile Phe Cys Tyr Thr Phe Ile Val Lys Thr 
225                 230                 235                 240 


Leu Val Gln Ala Gln Asn Ser Lys Arg His Lys Ala Ile Arg Val Ile 
                245                 250                 255     


Ile Ala Val Val Leu Val Phe Leu Ala Cys Gln Ile Pro His Asn Met 
            260                 265                 270         


Val Leu Leu Val Thr Ala Ala Asn Leu Gly Lys Met Asn Arg Ser Cys 
        275                 280                 285             


Gln Ser Glu Lys Leu Ile Gly Tyr Thr Lys Thr Val Thr Glu Val Leu 
    290                 295                 300                 


Ala Phe Leu His Cys Cys Leu Asn Pro Val Leu Tyr Ala Phe Ile Gly 
305                 310                 315                 320 


Gln Lys Phe Arg Asn Tyr Phe Leu Lys Ile Leu Lys Asp Leu Trp Cys 
                325                 330                 335     


Val Arg Arg Lys Tyr Lys Ser Ser Gly Phe Ser Cys Ala Gly Arg Tyr 
            340                 345                 350         


Ser Glu Asn Ile Ser Arg Gln Thr Ser Glu Thr Ala Asp Asn Asp Asn 
        355                 360                 365             


Ala Ser Ser Phe Thr Met 
    370                 


<210>  5222
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  5222

Met Gln Pro Ser Glu Met Val Met Asn Pro Lys Gln Val Phe Leu Ser 
1               5                   10                  15      


Val Leu Ile Phe Gly Val Ala Gly Leu Leu Leu Phe Met Tyr Leu Gln 
            20                  25                  30          


Val Trp Ile Glu Glu Gln His Thr Gly Arg Val Glu Lys Arg Arg Glu 
        35                  40                  45              


Gln Lys Val Thr Ser Gly Trp Gly Pro Val Lys Tyr Leu Arg Pro Val 
    50                  55                  60                  


Pro Arg Ile Met Ser Thr Glu Lys Ile Gln Glu His Ile Thr Asn Gln 
65                  70                  75                  80  


Asn Pro Lys Phe His Met Pro Glu Asp Val Arg Glu Lys Lys Glu Asn 
                85                  90                  95      


Leu Leu Leu Asn Ser Glu Arg Ser Thr Arg Leu Leu Thr Lys Thr Ser 
            100                 105                 110         


His Ser Gln Gly Gly Asp Gln Ala Leu Ser Lys Ser Thr Gly Ser Pro 
        115                 120                 125             


Thr Glu Lys Leu Ile Glu Lys Arg Gln Gly Ala Lys Thr Val Phe Asn 
    130                 135                 140                 


Lys Phe Ser Asn Met Asn Trp Pro Val Asp Ile His Pro Leu Asn Lys 
145                 150                 155                 160 


Ser Leu Val Lys Asp Asn Lys Trp Lys Lys Thr Glu Glu Thr Gln Glu 
                165                 170                 175     


Lys Arg Arg Ser Phe Leu Gln Glu Phe Cys Lys Lys Tyr Gly Gly Val 
            180                 185                 190         


Ser His His Gln Ser His Leu Phe His Thr Val Ser Arg Ile Tyr Val 
        195                 200                 205             


Glu Asp Lys His Lys Ile Leu Tyr Cys Glu Val Pro Lys Ala Gly Cys 
    210                 215                 220                 


Ser Asn Trp Lys Arg Ile Leu Met Val Leu Asn Gly Leu Ala Ser Ser 
225                 230                 235                 240 


Ala Tyr Asn Ile Ser His Asn Ala Val His Tyr Gly Lys His Leu Lys 
                245                 250                 255     


Lys Leu Asp Ser Phe Asp Leu Lys Gly Ile Tyr Thr Arg Leu Asn Thr 
            260                 265                 270         


Tyr Thr Lys Ala Val Phe Val Arg Asp Pro Met Glu Arg Leu Val Ser 
        275                 280                 285             


Ala Phe Arg Asp Lys Phe Glu His Pro Asn Ser Tyr Tyr His Pro Val 
    290                 295                 300                 


Phe Gly Lys Ala Ile Ile Lys Lys Tyr Arg Pro Asn Ala Cys Glu Glu 
305                 310                 315                 320 


Ala Leu Ile Asn Gly Ser Gly Val Lys Phe Lys Glu Phe Ile His Tyr 
                325                 330                 335     


Leu Leu Asp Ser His Arg Pro Val Gly Met Asp Ile His Trp Glu Lys 
            340                 345                 350         


Val Ser Lys Leu Cys Tyr Pro Cys Leu Ile Asn Tyr Asp Phe Val Gly 
        355                 360                 365             


Lys Phe Glu Thr Leu Glu Glu Asp Ala Asn Tyr Phe Leu Gln Met Ile 
    370                 375                 380                 


Gly Ala Pro Lys Glu Leu Lys Phe Pro Asn Phe Lys Asp Arg His Ser 
385                 390                 395                 400 


Ser Asp Glu Arg Thr Asn Ala Gln Val Val Arg Gln Tyr Leu Lys Asp 
                405                 410                 415     


Leu Thr Arg Thr Glu Arg Gln Leu Ile Tyr Asp Phe Tyr Tyr Leu Asp 
            420                 425                 430         


Tyr Leu Met Phe Asn Tyr Thr Thr Pro Phe Leu 
        435                 440             


<210>  5223
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  5223

Met Thr Leu Ile Glu Gly Val Gly Asp Glu Val Thr Val Leu Phe Ser 
1               5                   10                  15      


Val Leu Ala Cys Leu Leu Val Leu Ala Leu Ala Trp Val Ser Thr His 
            20                  25                  30          


Thr Ala Glu Gly Gly Asp Pro Leu Pro Gln Pro Ser Gly Thr Pro Thr 
        35                  40                  45              


Pro Ser Gln Pro Ser Ala Ala Met Ala Ala Thr Asp Ser Met Arg Gly 
    50                  55                  60                  


Glu Ala Pro Gly Ala Glu Thr Pro Ser Leu Arg His Arg Gly Gln Ala 
65                  70                  75                  80  


Ala Gln Pro Glu Pro Ser Thr Gly Phe Thr Ala Thr Pro Pro Ala Pro 
                85                  90                  95      


Asp Ser Pro Gln Glu Pro Leu Val Leu Arg Leu Lys Phe Leu Asn Asp 
            100                 105                 110         


Ser Glu Gln Val Ala Arg Ala Trp Pro His Asp Thr Ile Gly Ser Leu 
        115                 120                 125             


Lys Arg Thr Gln Phe Pro Gly Arg Glu Gln Gln Val Arg Leu Ile Tyr 
    130                 135                 140                 


Gln Gly Gln Leu Leu Gly Asp Asp Thr Gln Thr Leu Gly Ser Leu His 
145                 150                 155                 160 


Leu Pro Pro Asn Cys Val Leu His Cys His Val Ser Thr Arg Val Gly 
                165                 170                 175     


Pro Pro Asn Pro Pro Cys Pro Pro Gly Ser Glu Pro Gly Pro Ser Gly 
            180                 185                 190         


Leu Glu Ile Gly Ser Leu Leu Leu Pro Leu Leu Leu Leu Leu Leu Leu 
        195                 200                 205             


Leu Leu Trp Tyr Cys Gln Ile Gln Tyr Arg Pro Phe Phe Pro Leu Thr 
    210                 215                 220                 


Ala Thr Leu Gly Leu Ala Gly Phe Thr Leu Leu Leu Ser Leu Leu Ala 
225                 230                 235                 240 


Phe Ala Met Tyr Arg Pro 
                245     


<210>  5224
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  5224

Met Ala Gly Asp Thr Glu Val Trp Lys Gln Met Phe Gln Glu Leu Met 
1               5                   10                  15      


Arg Glu Val Lys Pro Trp His Arg Trp Thr Leu Arg Pro Asp Lys Gly 
            20                  25                  30          


Leu Leu Pro Asn Val Leu Lys Pro Gly Trp Met Gln Tyr Gln Gln Trp 
        35                  40                  45              


Thr Phe Ala Arg Phe Gln Cys Ser Ser Cys Ser Arg Asn Trp Ala Ser 
    50                  55                  60                  


Ala Gln Val Leu Val Leu Phe His Met Asn Trp Ser Glu Glu Lys Ser 
65                  70                  75                  80  


Arg Gly Gln Val Lys Met Arg Val Phe Thr Gln Arg Cys Lys Lys Cys 
                85                  90                  95      


Pro Gln Pro Leu Phe Glu Asp Pro Glu Phe Thr Gln Glu Asn Ile Ser 
            100                 105                 110         


Arg Ile Leu Lys Asn Leu Val Phe Arg Ile Leu Lys Lys Cys Tyr Arg 
        115                 120                 125             


Gly Arg Phe Gln Leu Ile Glu Glu Val Pro Met Ile Lys Asp Ile Ser 
    130                 135                 140                 


Leu Glu Gly Pro His Asn Ser Asp Asn Cys Glu Ala Cys Leu Gln Gly 
145                 150                 155                 160 


Phe Cys Ala Gly Pro Ile Gln Val Thr Ser Leu Pro Pro Ser Gln Thr 
                165                 170                 175     


Pro Arg Val His Ser Ile Tyr Lys Val Glu Glu Val Val Lys Pro Trp 
            180                 185                 190         


Ala Ser Gly Glu Asn Val Tyr Ser Tyr Ala Cys Gln Asn His Ile Cys 
        195                 200                 205             


Arg Asn Leu Ser Ile Phe Cys Cys Cys Val Ile Leu Ile Val Ile Val 
    210                 215                 220                 


Val Ile Val Val Lys Thr Ala Ile 
225                 230         


<210>  5225
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  5225

Met Ala Ser Ala Gly Ser Gly Met Glu Glu Val Arg Val Ser Val Leu 
1               5                   10                  15      


Thr Pro Leu Lys Leu Val Gly Leu Val Cys Ile Phe Leu Ala Leu Cys 
            20                  25                  30          


Leu Asp Leu Gly Ala Val Leu Ser Pro Ala Trp Val Thr Ala Asp His 
        35                  40                  45              


Gln Tyr Tyr Leu Ser Leu Trp Glu Ser Cys Arg Lys Pro Ala Ser Leu 
    50                  55                  60                  


Asp Ile Trp His Cys Glu Ser Thr Leu Ser Ser Asp Trp Gln Ile Ala 
65                  70                  75                  80  


Thr Leu Ala Leu Leu Leu Gly Gly Ala Ala Ile Ile Leu Ile Ala Phe 
                85                  90                  95      


Leu Val Gly Leu Ile Ser Ile Cys Val Gly Ser Arg Arg Arg Phe Tyr 
            100                 105                 110         


Arg Pro Val Ala Val Met Leu Phe Ala Ala Val Val Leu Gln Val Cys 
        115                 120                 125             


Ser Leu Val Leu Tyr Pro Ile Lys Phe Ile Glu Thr Val Ser Leu Lys 
    130                 135                 140                 


Ile Tyr His Glu Phe Asn Trp Gly Tyr Gly Leu Ala Trp Gly Ala Thr 
145                 150                 155                 160 


Ile Phe Ser Phe Gly Gly Ala Ile Leu Tyr Cys Leu Asn Pro Lys Asn 
                165                 170                 175     


Tyr Glu Asp Tyr Tyr 
            180     


<210>  5226
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  5226

Met Thr Ile Met Val Glu Asp Ile Met Lys Leu Leu Cys Ser Leu Ser 
1               5                   10                  15      


Gly Glu Arg Lys Met Lys Ala Ala Val Lys His Ser Gly Lys Gly Ala 
            20                  25                  30          


Leu Val Thr Gly Ala Met Ala Phe Val Gly Gly Leu Val Gly Gly Pro 
        35                  40                  45              


Pro Gly Leu Ala Val Gly Gly Ala Val Gly Gly Leu Leu Gly Ala Trp 
    50                  55                  60                  


Met Thr Ser Gly Gln Phe Lys Pro Val Pro Gln Ile Leu Met Glu Leu 
65                  70                  75                  80  


Pro Pro Ala Glu Gln Gln Arg Leu Phe Asn Glu Ala Ala Ala Ile Ile 
                85                  90                  95      


Arg His Leu Glu Trp Thr Asp Ala Val Gln Leu Thr Ala Leu Val Met 
            100                 105                 110         


Gly Ser Glu Ala Leu Gln Gln Gln Leu Leu Ala Met Leu Val Asn Tyr 
        115                 120                 125             


Val Thr Lys Glu Leu Arg Ala Glu Ile Gln Tyr Asp Asp 
    130                 135                 140     


<210>  5227
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  5227

Met Asn Ser Met Thr Ser Ala Val Pro Val Ala Asn Ser Val Leu Val 
1               5                   10                  15      


Val Ala Pro His Asn Gly Tyr Pro Val Thr Pro Gly Ile Met Ser His 
            20                  25                  30          


Val Pro Leu Tyr Pro Asn Ser Gln Pro Gln Val His Leu Val Pro Gly 
        35                  40                  45              


Asn Pro Pro Ser Leu Val Ser Asn Val Asn Gly Gln Pro Val Gln Lys 
    50                  55                  60                  


Ala Leu Lys Glu Gly Lys Thr Leu Gly Ala Ile Gln Ile Ile Ile Gly 
65                  70                  75                  80  


Leu Ala His Ile Gly Leu Gly Ser Ile Met Ala Thr Val Leu Val Gly 
                85                  90                  95      


Glu Tyr Leu Ser Ile Ser Phe Tyr Gly Gly Phe Pro Phe Trp Gly Gly 
            100                 105                 110         


Leu Trp Phe Ile Ile Ser Gly Ser Leu Ser Val Ala Ala Glu Asn Gln 
        115                 120                 125             


Pro Tyr Ser Tyr Cys Leu Leu Ser Gly Ser Leu Gly Leu Asn Ile Val 
    130                 135                 140                 


Ser Ala Ile Cys Ser Ala Val Gly Val Ile Leu Phe Ile Thr Asp Leu 
145                 150                 155                 160 


Ser Ile Pro His Pro Tyr Ala Tyr Pro Asp Tyr Tyr Pro Tyr Ala Trp 
                165                 170                 175     


Gly Val Asn Pro Gly Met Ala Ile Ser Gly Val Leu Leu Val Phe Cys 
            180                 185                 190         


Leu Leu Glu Phe Gly Ile Ala Cys Ala Ser Ser His Phe Gly Cys Gln 
        195                 200                 205             


Leu Val Cys Cys Gln Ser Ser Asn Val Ser Val Ile Tyr Pro Asn Ile 
    210                 215                 220                 


Tyr Ala Ala Asn Pro Val Ile Thr Pro Glu Pro Val Thr Ser Pro Pro 
225                 230                 235                 240 


Ser Tyr Ser Ser Glu Ile Gln Ala Asn Lys 
                245                 250 


<210>  5228
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  5228

Met Val Ala Trp Arg Ser Ala Phe Leu Val Cys Leu Ala Phe Ser Leu 
1               5                   10                  15      


Ala Thr Leu Val Gln Arg Gly Ser Gly Asp Phe Asp Asp Phe Asn Leu 
            20                  25                  30          


Glu Asp Ala Val Lys Glu Thr Ser Ser Val Lys Gln Pro Trp Asp His 
        35                  40                  45              


Thr Thr Thr Thr Thr Thr Asn Arg Pro Gly Thr Thr Arg Ala Pro Ala 
    50                  55                  60                  


Lys Pro Pro Gly Ser Gly Leu Asp Leu Ala Asp Ala Leu Asp Asp Gln 
65                  70                  75                  80  


Asp Asp Gly Arg Arg Lys Pro Gly Ile Gly Gly Arg Glu Arg Trp Asn 
                85                  90                  95      


His Val Thr Thr Thr Thr Lys Arg Pro Val Thr Thr Arg Ala Pro Ala 
            100                 105                 110         


Asn Thr Leu Gly Asn Asp Phe Asp Leu Ala Asp Ala Leu Asp Asp Arg 
        115                 120                 125             


Asn Asp Arg Asp Asp Gly Arg Arg Lys Pro Ile Ala Gly Gly Gly Gly 
    130                 135                 140                 


Phe Ser Asp Lys Asp Leu Glu Asp Ile Val Gly Gly Gly Glu Tyr Lys 
145                 150                 155                 160 


Pro Asp Lys Gly Lys Gly Asp Gly Arg Tyr Gly Ser Asn Asp Asp Pro 
                165                 170                 175     


Gly Ser Gly Met Val Ala Glu Pro Gly Thr Ile Ala Gly Val Ala Ser 
            180                 185                 190         


Ala Leu Ala Met Ala Leu Ile Gly Ala Val Ser Ser Tyr Ile Ser Tyr 
        195                 200                 205             


Gln Gln Lys Lys Phe Cys Phe Ser Ile Gln Gln Gly Leu Asn Ala Asp 
    210                 215                 220                 


Tyr Val Lys Gly Glu Asn Leu Glu Ala Val Val Cys Glu Glu Pro Gln 
225                 230                 235                 240 


Val Lys Tyr Ser Thr Leu His Thr Gln Ser Ala Glu Pro Pro Pro Pro 
                245                 250                 255     


Pro Glu Pro Ala Arg Ile 
            260         


<210>  5229
<211>  959
<212>  PRT
<213>  Homo sapiens

<400>  5229

Met Glu Met Lys Leu Pro Gly Gln Glu Gly Phe Glu Ala Ser Ser Ala 
1               5                   10                  15      


Pro Arg Asn Ile Pro Ser Gly Glu Leu Asp Ser Asn Pro Asp Pro Gly 
            20                  25                  30          


Thr Gly Pro Ser Pro Asp Gly Pro Ser Asp Thr Glu Ser Lys Glu Leu 
        35                  40                  45              


Gly Val Pro Lys Asp Pro Leu Leu Phe Ile Gln Leu Asn Glu Leu Leu 
    50                  55                  60                  


Gly Trp Pro Gln Ala Leu Glu Trp Arg Glu Thr Gly Arg Trp Val Leu 
65                  70                  75                  80  


Phe Glu Glu Lys Leu Glu Val Ala Ala Gly Arg Trp Ser Ala Pro His 
                85                  90                  95      


Val Pro Thr Leu Ala Leu Pro Ser Leu Gln Lys Leu Arg Ser Leu Leu 
            100                 105                 110         


Ala Glu Gly Leu Val Leu Leu Asp Cys Pro Ala Gln Ser Leu Leu Glu 
        115                 120                 125             


Leu Val Glu Gln Val Thr Arg Val Glu Ser Leu Ser Pro Glu Leu Arg 
    130                 135                 140                 


Gly Gln Leu Gln Ala Leu Leu Leu Gln Arg Pro Gln His Tyr Asn Gln 
145                 150                 155                 160 


Thr Thr Gly Thr Arg Pro Cys Trp Gly Ser Thr His Pro Arg Lys Ala 
                165                 170                 175     


Ser Asp Asn Glu Glu Ala Pro Leu Arg Glu Gln Cys Gln Asn Pro Leu 
            180                 185                 190         


Arg Gln Lys Leu Pro Pro Gly Ala Glu Ala Gly Thr Val Leu Ala Gly 
        195                 200                 205             


Glu Leu Gly Phe Leu Ala Gln Pro Leu Gly Ala Phe Val Arg Leu Arg 
    210                 215                 220                 


Asn Pro Val Val Leu Gly Ser Leu Thr Glu Val Ser Leu Pro Ser Arg 
225                 230                 235                 240 


Phe Phe Cys Leu Leu Leu Gly Pro Cys Met Leu Gly Lys Gly Tyr His 
                245                 250                 255     


Glu Met Gly Arg Ala Ala Ala Val Leu Leu Ser Asp Pro Gln Phe Gln 
            260                 265                 270         


Trp Ser Val Arg Arg Ala Ser Asn Leu His Asp Leu Leu Ala Ala Leu 
        275                 280                 285             


Asp Ala Phe Leu Glu Glu Val Thr Val Leu Pro Pro Gly Arg Trp Asp 
    290                 295                 300                 


Pro Thr Ala Arg Ile Pro Pro Pro Lys Cys Leu Pro Ser Gln His Lys 
305                 310                 315                 320 


Arg Leu Pro Ser Gln Gln Arg Glu Ile Arg Gly Pro Ala Val Pro Arg 
                325                 330                 335     


Leu Thr Ser Ala Glu Asp Arg His Arg His Gly Pro His Ala His Ser 
            340                 345                 350         


Pro Glu Leu Gln Arg Thr Gly Arg Leu Phe Gly Gly Leu Ile Gln Asp 
        355                 360                 365             


Val Arg Arg Lys Val Pro Trp Tyr Pro Ser Asp Phe Leu Asp Ala Leu 
    370                 375                 380                 


His Leu Gln Cys Phe Ser Ala Val Leu Tyr Ile Tyr Leu Ala Thr Val 
385                 390                 395                 400 


Thr Asn Ala Ile Thr Phe Gly Gly Leu Leu Gly Asp Ala Thr Asp Gly 
                405                 410                 415     


Ala Gln Gly Val Leu Glu Ser Phe Leu Gly Thr Ala Val Ala Gly Ala 
            420                 425                 430         


Ala Phe Cys Leu Met Ala Gly Gln Pro Leu Thr Ile Leu Ser Ser Thr 
        435                 440                 445             


Gly Pro Val Leu Val Phe Glu Arg Leu Leu Phe Ser Phe Ser Arg Asp 
    450                 455                 460                 


Tyr Ser Leu Asp Tyr Leu Pro Phe Arg Leu Trp Val Gly Ile Trp Val 
465                 470                 475                 480 


Ala Thr Phe Cys Leu Val Leu Val Ala Thr Glu Ala Ser Val Leu Val 
                485                 490                 495     


Arg Tyr Phe Thr Arg Phe Thr Glu Glu Gly Phe Cys Ala Leu Ile Ser 
            500                 505                 510         


Leu Ile Phe Ile Tyr Asp Ala Val Gly Lys Met Leu Asn Leu Thr His 
        515                 520                 525             


Thr Tyr Pro Ile Gln Lys Pro Gly Ser Ser Ala Tyr Gly Cys Leu Cys 
    530                 535                 540                 


Gln Tyr Pro Gly Pro Gly Gly Asn Glu Ser Gln Trp Ile Arg Thr Arg 
545                 550                 555                 560 


Pro Lys Asp Arg Asp Asp Ile Val Ser Met Asp Leu Gly Leu Ile Asn 
                565                 570                 575     


Ala Ser Leu Leu Pro Pro Pro Glu Cys Thr Arg Gln Gly Gly His Pro 
            580                 585                 590         


Arg Gly Pro Gly Cys His Thr Val Pro Asp Ile Ala Phe Phe Ser Leu 
        595                 600                 605             


Leu Leu Phe Leu Thr Ser Phe Phe Phe Ala Met Ala Leu Lys Cys Val 
    610                 615                 620                 


Lys Thr Ser Arg Phe Phe Pro Ser Val Val Arg Lys Gly Leu Ser Asp 
625                 630                 635                 640 


Phe Ser Ser Val Leu Ala Ile Leu Leu Gly Cys Gly Leu Asp Ala Phe 
                645                 650                 655     


Leu Gly Leu Ala Thr Pro Lys Leu Met Val Pro Arg Glu Phe Lys Pro 
            660                 665                 670         


Thr Leu Pro Gly Arg Gly Trp Leu Val Ser Pro Phe Gly Ala Asn Pro 
        675                 680                 685             


Trp Trp Trp Ser Val Ala Ala Ala Leu Pro Ala Leu Leu Leu Ser Ile 
    690                 695                 700                 


Leu Ile Phe Met Asp Gln Gln Ile Thr Ala Val Ile Leu Asn Arg Met 
705                 710                 715                 720 


Glu Tyr Arg Leu Gln Lys Gly Ala Gly Phe His Leu Asp Leu Phe Cys 
                725                 730                 735     


Val Ala Val Leu Met Leu Leu Thr Ser Ala Leu Gly Leu Pro Trp Tyr 
            740                 745                 750         


Val Ser Ala Thr Val Ile Ser Leu Ala His Met Asp Ser Leu Arg Arg 
        755                 760                 765             


Glu Ser Arg Ala Cys Ala Pro Gly Glu Arg Pro Asn Phe Leu Gly Ile 
    770                 775                 780                 


Arg Glu Gln Arg Leu Thr Gly Leu Val Val Phe Ile Leu Thr Gly Ala 
785                 790                 795                 800 


Ser Ile Phe Leu Ala Pro Val Leu Lys Phe Ile Pro Met Pro Val Leu 
                805                 810                 815     


Tyr Gly Ile Phe Leu Tyr Met Gly Val Ala Ala Leu Ser Ser Ile Gln 
            820                 825                 830         


Phe Thr Asn Arg Val Lys Leu Leu Leu Met Pro Ala Lys His Gln Pro 
        835                 840                 845             


Asp Leu Leu Leu Leu Arg His Val Pro Leu Thr Arg Val His Leu Phe 
    850                 855                 860                 


Thr Ala Ile Gln Leu Ala Cys Leu Gly Leu Leu Trp Ile Ile Lys Ser 
865                 870                 875                 880 


Thr Pro Ala Ala Ile Ile Phe Pro Leu Met Leu Leu Gly Leu Val Gly 
                885                 890                 895     


Val Arg Lys Ala Leu Glu Arg Val Phe Ser Pro Gln Glu Leu Leu Trp 
            900                 905                 910         


Leu Asp Glu Leu Met Pro Glu Glu Glu Arg Ser Ile Pro Glu Lys Gly 
        915                 920                 925             


Leu Glu Pro Glu His Ser Phe Ser Gly Ser Asp Ser Glu Asp Ser Glu 
    930                 935                 940                 


Leu Met Tyr Gln Pro Lys Ala Pro Glu Ile Asn Ile Ser Val Asn 
945                 950                 955                 


<210>  5230
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  5230

Met Arg Leu Pro Glu Gln Pro Gly Glu Gly Lys Pro Glu Asn Glu Lys 
1               5                   10                  15      


Lys Gly Asp Gly Gly Ala Leu Gly Gly Gly Glu Glu Pro Pro Arg Ser 
            20                  25                  30          


Gln Ala Pro Asp Phe Pro Thr Trp Glu Lys Met Pro Phe His His Val 
        35                  40                  45              


Thr Ala Gly Leu Leu Tyr Lys Gly Asn Tyr Leu Asn Arg Ser Leu Ser 
    50                  55                  60                  


Ala Gly Ser Asp Ser Glu Gln Leu Ala Asn Ile Ser Val Glu Glu Leu 
65                  70                  75                  80  


Asp Glu Ile Arg Glu Ala Phe Arg Val Leu Asp Arg Asp Gly Asn Gly 
                85                  90                  95      


Phe Ile Ser Lys Gln Glu Leu Gly Met Ala Met Arg Ser Leu Gly Tyr 
            100                 105                 110         


Met Pro Ser Glu Val Glu Leu Ala Ile Ile Met Gln Arg Leu Asp Met 
        115                 120                 125             


Asp Gly Asp Gly Gln Val Asp Phe Asp Glu Phe Met Thr Ile Leu Gly 
    130                 135                 140                 


Pro Lys Leu Val Ser Ser Glu Gly Arg Asp Gly Phe Leu Gly Asn Thr 
145                 150                 155                 160 


Ile Asp Ser Ile Phe Trp Gln Phe Asp Met Gln Arg Ile Thr Leu Glu 
                165                 170                 175     


Glu Leu Lys His Ile Leu Tyr His Ala Phe Arg Asp His Leu Thr Met 
            180                 185                 190         


Lys Asp Ile Glu Asn Ile Ile Ile Asn Glu Glu Glu Ser Leu Asn Glu 
        195                 200                 205             


Thr Ser Gly Asn Cys Gln Thr Glu Phe Glu Gly Val His Ser Gln Lys 
    210                 215                 220                 


Gln Asn Arg Gln Thr Cys Val Arg Lys Ser Leu Ile Cys Ala Phe Ala 
225                 230                 235                 240 


Met Ala Phe Ile Ile Ser Val Met Leu Ile Ala Ala Asn Gln Ile Leu 
                245                 250                 255     


Arg Ser Gly Met Glu 
            260     


<210>  5231
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  5231

Met Ser Cys Val Leu Gly Gly Val Ile Pro Leu Gly Leu Leu Phe Leu 
1               5                   10                  15      


Val Cys Gly Ser Gln Gly Tyr Leu Leu Pro Asn Val Thr Leu Leu Glu 
            20                  25                  30          


Glu Leu Leu Ser Lys Tyr Gln His Asn Glu Ser His Ser Arg Val Arg 
        35                  40                  45              


Arg Ala Ile Pro Arg Glu Asp Lys Glu Glu Ile Leu Met Leu His Asn 
    50                  55                  60                  


Lys Leu Arg Gly Gln Val Gln Pro Gln Ala Ser Asn Met Glu Tyr Met 
65                  70                  75                  80  


Thr Trp Asp Asp Glu Leu Glu Lys Ser Ala Ala Ala Trp Ala Ser Gln 
                85                  90                  95      


Cys Ile Trp Glu His Gly Pro Thr Ser Leu Leu Val Ser Ile Gly Gln 
            100                 105                 110         


Asn Leu Gly Ala His Trp Gly Arg Tyr Arg Ser Pro Gly Phe His Val 
        115                 120                 125             


Gln Ser Trp Tyr Asp Glu Val Lys Asp Tyr Thr Tyr Pro Tyr Pro Ser 
    130                 135                 140                 


Glu Cys Asn Pro Trp Cys Pro Glu Arg Cys Ser Gly Pro Met Cys Thr 
145                 150                 155                 160 


His Tyr Thr Gln Ile Val Trp Ala Thr Thr Asn Lys Ile Gly Cys Ala 
                165                 170                 175     


Val Asn Thr Cys Arg Lys Met Thr Val Trp Gly Glu Val Trp Glu Asn 
            180                 185                 190         


Ala Val Tyr Phe Val Cys Asn Tyr Ser Pro Lys Gly Asn Trp Ile Gly 
        195                 200                 205             


Glu Ala Pro Tyr Lys Asn Gly Arg Pro Cys Ser Glu Cys Pro Pro Ser 
    210                 215                 220                 


Tyr Gly Gly Ser Cys Arg Asn Asn Leu Cys Tyr Arg Glu Glu Thr Tyr 
225                 230                 235                 240 


Thr Pro Lys Pro Glu Thr Asp Glu Met Asn Glu Val Glu Thr Ala Pro 
                245                 250                 255     


Ile Pro Glu Glu Asn His Val Trp Leu Gln Pro Arg Val Met Arg Pro 
            260                 265                 270         


Thr Lys Pro Lys Lys Thr Ser Ala Val Asn Tyr Met Thr Gln Val Val 
        275                 280                 285             


Arg Cys Asp Thr Lys Met Lys Asp Arg Cys Lys Gly Ser Thr Cys Asn 
    290                 295                 300                 


Arg Tyr Gln Cys Pro Ala Gly Cys Leu Asn His Lys Ala Lys Ile Phe 
305                 310                 315                 320 


Gly Thr Leu Phe Tyr Glu Ser Ser Ser Ser Ile Cys Arg Ala Ala Ile 
                325                 330                 335     


His Tyr Gly Ile Leu Asp Asp Lys Gly Gly Leu Val Asp Ile Thr Arg 
            340                 345                 350         


Asn Gly Lys Val Pro Phe Phe Val Lys Ser Glu Arg His Gly Val Gln 
        355                 360                 365             


Ser Leu Ser Lys Tyr Lys Pro Ser Ser Ser Phe Met Val Ser Lys Val 
    370                 375                 380                 


Lys Val Gln Asp Leu Asp Cys Tyr Thr Thr Val Ala Gln Leu Cys Pro 
385                 390                 395                 400 


Phe Glu Lys Pro Ala Thr His Cys Pro Arg Ile His Cys Pro Ala His 
                405                 410                 415     


Cys Lys Asp Glu Pro Ser Tyr Trp Ala Pro Val Phe Gly Thr Asn Ile 
            420                 425                 430         


Tyr Ala Asp Thr Ser Ser Ile Cys Lys Thr Ala Val His Ala Gly Val 
        435                 440                 445             


Ile Ser Asn Glu Ser Gly Gly Asp Val Asp Val Met Pro Val Asp Lys 
    450                 455                 460                 


Lys Lys Thr Tyr Val Gly Ser Leu Arg Asn Gly Val Gln Ser Glu Ser 
465                 470                 475                 480 


Leu Gly Thr Pro Arg Asp Gly Lys Ala Phe Arg Ile Phe Ala Val Arg 
                485                 490                 495     


Gln 
    


<210>  5232
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  5232

Met Leu Thr Pro Met Val Ala Gly Gly Val Val Phe Pro Gly Leu Phe 
1               5                   10                  15      


Leu Leu Ser Lys Asn Thr Leu Gln Arg Leu Pro Gln Leu Arg Trp Glu 
            20                  25                  30          


Glu Ala Asp Ala Val Ile Val Ser Ala Arg Leu Val Ser Ser Val Gln 
        35                  40                  45              


Ala Ile Met Ala Ser Thr Ala Gly Tyr Ile Val Ser Thr Ser Cys Lys 
    50                  55                  60                  


His Ile Ile Asp Asp Gln His Trp Leu Ser Ser Ala Tyr Thr Gln Phe 
65                  70                  75                  80  


Ala Val Pro Tyr Phe Ile Tyr Asp Ile Tyr Ala Met Phe Leu Cys His 
                85                  90                  95      


Trp His Lys His Gln Val Lys Gly His Gly Gly Asp Asp Gly Ala Ala 
            100                 105                 110         


Arg Ala Pro Gly Ser Thr Trp Ala Ile Ala Arg Gly Tyr Leu His Lys 
        115                 120                 125             


Glu Phe Leu Met Val Leu His His Ala Ala Met Val Leu Val Cys Phe 
    130                 135                 140                 


Pro Leu Ser Val Val Trp Arg Gln Gly Lys Gly Asp Phe Phe Leu Gly 
145                 150                 155                 160 


Cys Met Leu Met Ala Glu Val Ser Thr Pro Phe Val Cys Leu Gly Lys 
                165                 170                 175     


Ile Leu Ile Gln Tyr Lys Gln Gln His Thr Leu Leu His Lys Val Asn 
            180                 185                 190         


Gly Ala Leu Met Leu Leu Ser Phe Leu Cys Cys Arg Val Leu Leu Phe 
        195                 200                 205             


Pro Tyr Leu Tyr Trp Ala Tyr Gly Arg His Ala Gly Leu Pro Leu Leu 
    210                 215                 220                 


Ala Val Pro Leu Ala Ile Pro Ala His Val Asn Leu Gly Ala Ala Leu 
225                 230                 235                 240 


Leu Leu Ala Pro Gln Leu Tyr Trp Phe Phe Leu Ile Cys Arg Gly Ala 
                245                 250                 255     


Cys Arg Leu Phe Trp Pro Arg Ser Arg Pro Pro Pro Ala Cys Gln Ala 
            260                 265                 270         


Gln Asp 
        


<210>  5233
<211>  315
<212>  PRT
<213>  Homo sapiens

<400>  5233

Met Thr His Gln Asp Leu Ser Ile Thr Ala Lys Leu Ile Asn Gly Gly 
1               5                   10                  15      


Val Ala Gly Leu Val Gly Val Thr Cys Val Phe Pro Ile Asp Leu Ala 
            20                  25                  30          


Lys Thr Arg Leu Gln Asn Gln His Gly Lys Ala Met Tyr Lys Gly Met 
        35                  40                  45              


Ile Asp Cys Leu Met Lys Thr Ala Arg Ala Glu Gly Phe Phe Gly Met 
    50                  55                  60                  


Tyr Arg Gly Ala Ala Val Asn Leu Thr Leu Val Thr Pro Glu Lys Ala 
65                  70                  75                  80  


Ile Lys Leu Ala Ala Asn Asp Phe Phe Arg Arg Leu Leu Met Glu Asp 
                85                  90                  95      


Gly Met Gln Arg Asn Leu Lys Met Glu Met Leu Ala Gly Cys Gly Ala 
            100                 105                 110         


Gly Met Cys Gln Val Val Val Thr Cys Pro Met Glu Met Leu Lys Ile 
        115                 120                 125             


Gln Leu Gln Asp Ala Gly Arg Leu Ala Val His His Gln Gly Ser Ala 
    130                 135                 140                 


Ser Ala Pro Ser Thr Ser Arg Ser Tyr Thr Thr Gly Ser Ala Ser Thr 
145                 150                 155                 160 


His Arg Arg Pro Ser Ala Thr Leu Ile Ala Trp Glu Leu Leu Arg Thr 
                165                 170                 175     


Gln Gly Leu Ala Gly Leu Tyr Arg Gly Leu Gly Ala Thr Leu Leu Arg 
            180                 185                 190         


Asp Ile Pro Phe Ser Ile Ile Tyr Phe Pro Leu Phe Ala Asn Leu Asn 
        195                 200                 205             


Asn Leu Gly Phe Asn Glu Leu Ala Gly Lys Ala Ser Phe Ala His Ser 
    210                 215                 220                 


Phe Val Ser Gly Cys Val Ala Gly Ser Ile Ala Ala Val Ala Val Thr 
225                 230                 235                 240 


Pro Leu Asp Val Leu Lys Thr Arg Ile Gln Thr Leu Lys Lys Gly Leu 
                245                 250                 255     


Gly Glu Asp Met Tyr Ser Gly Ile Thr Asp Cys Ala Arg Lys Leu Trp 
            260                 265                 270         


Ile Gln Glu Gly Pro Ser Ala Phe Met Lys Gly Ala Gly Cys Arg Ala 
        275                 280                 285             


Leu Val Ile Ala Pro Leu Phe Gly Ile Ala Gln Gly Val Tyr Phe Ile 
    290                 295                 300                 


Gly Ile Gly Glu Arg Ile Leu Lys Cys Phe Asp 
305                 310                 315 


<210>  5234
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  5234

Met Leu Pro Pro Pro Pro Arg Gln Pro Pro Pro Gln Ala Arg Ala Ala 
1               5                   10                  15      


Arg Gly Ala Val Arg Leu Gln Arg Pro Phe Leu Arg Ser Pro Leu Gly 
            20                  25                  30          


Val Leu Arg Leu Leu Gln Leu Leu Ala Gly Ala Ala Phe Trp Ile Thr 
        35                  40                  45              


Ile Ala Thr Ser Lys Tyr Gln Gly Pro Val His Phe Ala Leu Phe Val 
    50                  55                  60                  


Ser Val Leu Phe Trp Leu Leu Thr Leu Gly Leu Tyr Phe Leu Thr Leu 
65                  70                  75                  80  


Leu Gly Lys His Glu Leu Val Pro Val Leu Gly Ser Arg Trp Leu Met 
                85                  90                  95      


Val Asn Val Ala His Asp Val Leu Ala Ala Ala Leu Tyr Gly Ala Ala 
            100                 105                 110         


Thr Gly Ile Met Ser Asp Gln Met Gln Arg His Ser Tyr Cys Asn Leu 
        115                 120                 125             


Lys Asp Tyr Pro Leu Pro Cys Ala Tyr His Ala Phe Leu Ala Ala Ala 
    130                 135                 140                 


Val Cys Gly Gly Val Cys His Gly Leu Tyr Leu Leu Ser Ala Leu Tyr 
145                 150                 155                 160 


Gly Cys Gly Arg Arg Cys Gln Gly Lys Gln Glu Val Ala 
                165                 170             


<210>  5235
<211>  705
<212>  PRT
<213>  Homo sapiens

<400>  5235

Met Glu Lys Pro Arg Ser Ile Glu Glu Thr Pro Ser Ser Glu Pro Met 
1               5                   10                  15      


Glu Glu Glu Glu Asp Asp Asp Leu Glu Leu Phe Gly Gly Tyr Asp Ser 
            20                  25                  30          


Phe Arg Ser Tyr Asn Ser Ser Val Gly Ser Glu Ser Ser Ser Tyr Leu 
        35                  40                  45              


Glu Glu Ser Ser Glu Ala Glu Asn Glu Asp Arg Glu Ala Gly Glu Leu 
    50                  55                  60                  


Pro Thr Ser Pro Leu His Leu Leu Ser Pro Gly Thr Pro Arg Ser Leu 
65                  70                  75                  80  


Asp Gly Ser Gly Ser Glu Pro Ala Val Cys Glu Met Cys Gly Ile Val 
                85                  90                  95      


Gly Thr Arg Glu Ala Phe Phe Ser Lys Thr Lys Arg Phe Cys Ser Val 
            100                 105                 110         


Ser Cys Ser Arg Ser Tyr Ser Ser Asn Ser Lys Lys Ala Ser Ile Leu 
        115                 120                 125             


Ala Arg Leu Gln Gly Lys Pro Pro Thr Lys Lys Ala Lys Val Leu His 
    130                 135                 140                 


Lys Ala Ala Trp Ser Ala Lys Ile Gly Ala Phe Leu His Ser Gln Gly 
145                 150                 155                 160 


Thr Gly Gln Leu Ala Asp Gly Thr Pro Thr Gly Gln Asp Ala Leu Val 
                165                 170                 175     


Leu Gly Phe Asp Trp Gly Lys Phe Leu Lys Asp His Ser Tyr Lys Ala 
            180                 185                 190         


Ala Pro Val Ser Cys Phe Lys His Val Pro Leu Tyr Asp Gln Trp Glu 
        195                 200                 205             


Asp Val Met Lys Gly Met Lys Val Glu Val Leu Asn Ser Asp Ala Val 
    210                 215                 220                 


Leu Pro Ser Arg Val Tyr Trp Ile Ala Ser Val Ile Gln Thr Ala Gly 
225                 230                 235                 240 


Tyr Arg Val Leu Leu Arg Tyr Glu Gly Phe Glu Asn Asp Ala Ser His 
                245                 250                 255     


Asp Phe Trp Cys Asn Leu Gly Thr Val Asp Val His Pro Ile Gly Trp 
            260                 265                 270         


Cys Ala Ile Asn Ser Lys Ile Leu Val Pro Pro Arg Thr Ile His Ala 
        275                 280                 285             


Lys Phe Thr Asp Trp Lys Gly Tyr Leu Met Lys Arg Leu Val Gly Ser 
    290                 295                 300                 


Arg Thr Leu Pro Val Asp Phe His Ile Lys Met Val Glu Ser Met Lys 
305                 310                 315                 320 


Tyr Pro Phe Arg Gln Gly Met Arg Leu Glu Val Val Asp Lys Ser Gln 
                325                 330                 335     


Val Ser Arg Thr Arg Met Ala Val Val Asp Thr Val Ile Gly Gly Arg 
            340                 345                 350         


Leu Arg Leu Leu Tyr Glu Asp Gly Asp Ser Asp Asp Asp Phe Trp Cys 
        355                 360                 365             


His Met Trp Ser Pro Leu Ile His Pro Val Gly Trp Ser Arg Arg Val 
    370                 375                 380                 


Gly His Gly Ile Lys Met Ser Glu Arg Arg Ser Asp Met Ala His His 
385                 390                 395                 400 


Pro Thr Phe Arg Lys Ile Tyr Cys Asp Ala Val Pro Tyr Leu Phe Lys 
                405                 410                 415     


Lys Val Arg Ala Val Tyr Thr Glu Gly Gly Trp Phe Glu Glu Gly Met 
            420                 425                 430         


Lys Leu Glu Ala Ile Asp Pro Leu Asn Leu Gly Asn Ile Cys Val Ala 
        435                 440                 445             


Thr Val Cys Lys Val Leu Leu Asp Gly Tyr Leu Met Ile Cys Val Asp 
    450                 455                 460                 


Gly Gly Pro Ser Thr Asp Gly Leu Asp Trp Phe Cys Tyr His Ala Ser 
465                 470                 475                 480 


Ser His Ala Ile Phe Pro Ala Thr Phe Cys Gln Lys Asn Asp Ile Glu 
                485                 490                 495     


Leu Thr Pro Pro Lys Gly Tyr Glu Ala Gln Thr Phe Asn Trp Glu Asn 
            500                 505                 510         


Tyr Leu Glu Lys Thr Lys Ser Lys Ala Ala Pro Ser Arg Leu Phe Asn 
        515                 520                 525             


Met Asp Cys Pro Asn His Gly Phe Lys Val Gly Met Lys Leu Glu Ala 
    530                 535                 540                 


Val Asp Leu Met Glu Pro Arg Leu Ile Cys Val Ala Thr Val Lys Arg 
545                 550                 555                 560 


Val Val His Arg Leu Leu Ser Ile His Phe Asp Gly Trp Asp Ser Glu 
                565                 570                 575     


Tyr Asp Gln Trp Val Asp Cys Glu Ser Pro Asp Ile Tyr Pro Val Gly 
            580                 585                 590         


Trp Cys Glu Leu Thr Gly Tyr Gln Leu Gln Pro Pro Val Ala Ala Glu 
        595                 600                 605             


Pro Ala Thr Pro Leu Lys Ala Lys Glu Ala Thr Lys Lys Lys Lys Lys 
    610                 615                 620                 


Gln Phe Gly Lys Lys Arg Lys Arg Ile Pro Pro Thr Lys Thr Arg Pro 
625                 630                 635                 640 


Leu Arg Gln Gly Ser Lys Lys Pro Leu Leu Glu Asp Asp Pro Gln Gly 
                645                 650                 655     


Ala Arg Lys Ile Ser Ser Glu Pro Val Pro Gly Glu Ile Ile Ala Val 
            660                 665                 670         


Arg Val Lys Glu Glu His Leu Asp Val Ala Ser Pro Asp Lys Ala Ser 
        675                 680                 685             


Ser Pro Glu Leu Pro Val Ser Val Glu Asn Ile Lys Gln Glu Thr Asp 
    690                 695                 700                 


Asp 
705 


<210>  5236
<211>  824
<212>  PRT
<213>  Homo sapiens

<400>  5236

Met Ala Ser Ser Ile Arg Arg Gly Arg Gly Ala Trp Thr Arg Leu Leu 
1               5                   10                  15      


Ser Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu Arg 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Glu Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Val Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Glu Val Glu Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Ile Phe Pro Met Thr Val Lys Thr Ile Arg Phe Pro Glu 
    130                 135                 140                 


Ser Arg Leu Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Val Asn Ala Leu Leu Ser Tyr Lys Leu Ser Ser Ser Glu 
                165                 170                 175     


Phe Phe Phe Leu Asp Ile Gln Ala Asn Asp Glu Leu Ser Glu Ser Leu 
            180                 185                 190         


Ser Leu Val Leu Gly Lys Ser Leu Asp Arg Glu Glu Thr Ala Glu Val 
        195                 200                 205             


Asn Leu Leu Leu Val Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Ile Leu Ile Lys Val Leu Asp Val Asn Asp Asn Glu Pro 
225                 230                 235                 240 


Thr Phe Ala Gln Ser Val Tyr Lys Val Lys Leu Leu Glu Asn Thr Ala 
                245                 250                 255     


Asn Gly Thr Leu Val Val Lys Leu Asn Ala Ser Asp Ala Asp Glu Gly 
            260                 265                 270         


Pro Asn Ser Glu Ile Val Tyr Ser Leu Gly Ser Asp Val Ser Ser Thr 
        275                 280                 285             


Ile Gln Thr Lys Phe Thr Ile Asp Pro Ile Ser Gly Glu Ile Arg Thr 
    290                 295                 300                 


Lys Gly Lys Leu Asp Tyr Glu Glu Ala Lys Ser Tyr Glu Ile Gln Val 
305                 310                 315                 320 


Thr Ala Thr Asp Lys Gly Thr Pro Ser Met Ser Gly His Cys Lys Ile 
                325                 330                 335     


Ser Leu Lys Leu Val Asp Ile Asn Asp Asn Thr Pro Glu Val Ser Ile 
            340                 345                 350         


Thr Ser Leu Ser Leu Pro Ile Ser Glu Asn Ala Ser Leu Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Thr Val Ser Asp Arg Asp Ser Gly Thr Asn Gly His 
    370                 375                 380                 


Val Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Thr Ser Val Ser Ile Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Val 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Ala Pro Arg Ala Gly Thr Ala Ala Gly Ala 
                565                 570                 575     


Val Ser Glu Leu Val Pro Trp Ser Val Gly Ala Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Leu Gly Thr Gly Ser Ala Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Ala 
625                 630                 635                 640 


Asp Ser Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Ala Trp Val Gly Ala Ala Gly 
        675                 680                 685             


Ser Glu Ala Thr Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Val Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Val Pro Pro Thr Glu Gly Ala Arg Ala Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Gln Arg Val Cys Ser Gly Glu Asp Pro Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Ser Gln Gly Pro Asp Ser Ala Glu 
    770                 775                 780                 


Glu Lys Gln Leu Ser Glu Ser Glu Tyr Val Gly Lys Val Ser Leu Leu 
785                 790                 795                 800 


Leu Phe Leu Ala Asn Ser Lys Ile Val Leu Phe Lys Lys Phe Tyr Met 
                805                 810                 815     


Ile Ser Thr Ser Tyr Leu Asp Ser 
            820                 


<210>  5237
<211>  816
<212>  PRT
<213>  Homo sapiens

<400>  5237

Met Val Tyr Ser Arg Arg Gly Ser Leu Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Trp Leu Leu Leu Ala Tyr Trp Lys Ala Gly Ser Gly Gln Leu His Tyr 
            20                  25                  30          


Ser Ile Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile Ala 
        35                  40                  45              


Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe Arg 
    50                  55                  60                  


Val Ala Ser Lys Gly Arg Gly Asp Leu Leu Glu Val Asn Leu Gln Asn 
65                  70                  75                  80  


Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys Arg 
                85                  90                  95      


Arg Arg Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg Pro 
            100                 105                 110         


Leu Gln Val Phe His Val Glu Val Ala Val Lys Asp Ile Asn Asp Asn 
        115                 120                 125             


Pro Pro Arg Phe Ser Arg Gln Glu Gln Arg Leu Phe Ile Leu Glu Ser 
    130                 135                 140                 


Arg Met Pro Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Leu Asp 
145                 150                 155                 160 


Ile Gly Ala Asn Ala Gln Leu Arg Tyr Arg Leu Asn Pro Asn Glu Tyr 
                165                 170                 175     


Phe Asp Leu Asp Val Lys Thr Asn Glu Glu Glu Thr Asn Phe Leu Glu 
            180                 185                 190         


Leu Val Leu Arg Lys Ser Leu Asp Arg Glu Glu Thr Gln Glu His Arg 
        195                 200                 205             


Leu Leu Val Ile Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly Thr 
    210                 215                 220                 


Val Gln Leu Leu Ile Asn Val Leu Asp Ala Asn Asp Asn Ala Pro Glu 
225                 230                 235                 240 


Phe Asp Lys Ser Ile Tyr Asn Val Arg Leu Leu Glu Asn Ala Pro Ser 
                245                 250                 255     


Gly Thr Leu Val Ile Lys Leu Asn Ala Ser Asp Ala Asp Glu Gly Ile 
            260                 265                 270         


Asn Lys Glu Ile Val Tyr Phe Phe Ser Asn Leu Val Leu Asp Asp Val 
        275                 280                 285             


Lys Ser Lys Phe Ile Ile Asn Ser Asn Thr Gly Glu Ile Lys Val Asn 
    290                 295                 300                 


Gly Glu Leu Asp Tyr Glu Asp Tyr Asn Ser Tyr Glu Ile Asn Ile Asp 
305                 310                 315                 320 


Ala Met Asp Lys Ser Thr Phe Pro Leu Ser Gly His Cys Lys Val Val 
                325                 330                 335     


Val Lys Leu Leu Asp Val Asn Asp Asn Thr Pro Glu Met Ala Ile Thr 
            340                 345                 350         


Thr Leu Phe Leu Pro Val Lys Glu Asp Ala Pro Leu Ser Thr Val Ile 
        355                 360                 365             


Ala Leu Ile Ser Val Ser Asp Arg Asp Ser Gly Ala Asn Gly Gln Val 
    370                 375                 380                 


Thr Cys Ser Leu Met Pro His Val Pro Phe Lys Leu Val Ser Thr Phe 
385                 390                 395                 400 


Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu Ser 
                405                 410                 415     


Val Ser Val Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser Pro 
            420                 425                 430         


Ser Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Ala Phe Ala Gln Pro Gln Tyr Thr Val Phe Val Lys 
    450                 455                 460                 


Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg Asp 
465                 470                 475                 480 


Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu Arg 
                485                 490                 495     


Arg Val Gly Glu Arg Pro Leu Ser Ser Tyr Val Ser Val His Ala Glu 
            500                 505                 510         


Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Val Glu 
        515                 520                 525             


Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro Leu 
    530                 535                 540                 


Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Leu Leu Val Pro Arg Val Gly Gly Thr Gly Gly Ala Val 
                565                 570                 575     


Ser Glu Leu Val Pro Arg Ser Val Gly Ala Gly His Val Val Ala Lys 
            580                 585                 590         


Val Arg Ala Val Asp Pro Asp Ser Gly Tyr Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Glu Leu Gln Pro Ala Pro Gly Ser Ala Arg Ile Pro Phe Arg Val Gly 
    610                 615                 620                 


Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ser Leu Asp Glu Thr Glu 
625                 630                 635                 640 


Ala Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu Pro 
                645                 650                 655     


Pro Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser Gly 
            660                 665                 670         


Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Ala Gly Ala Val Gly Pro 
        675                 680                 685             


Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile Cys 
    690                 695                 700                 


Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala Leu 
705                 710                 715                 720 


Arg Cys Ser Ala Gln Pro Thr Glu Ala Val Cys Thr Arg Gly Lys Pro 
                725                 730                 735     


Thr Leu Leu Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln Gln 
            740                 745                 750         


Arg Arg Gln Arg Val Cys Ser Gly Glu Ala Pro Pro Lys Thr Asp Leu 
        755                 760                 765             


Met Ala Phe Ser Pro Ser Leu Pro Gln Gly Pro Thr Ser Thr Asp Asn 
    770                 775                 780                 


Val Ser Phe Leu Ile Leu Thr Ser Ile Phe Pro Ser Gln Phe Ser Asn 
785                 790                 795                 800 


Ile Lys Cys His Ile His Pro Leu Phe Leu Tyr Leu Lys Ile Met Ser 
                805                 810                 815     


<210>  5238
<211>  803
<212>  PRT
<213>  Homo sapiens

<400>  5238

Met Val Phe Thr Pro Glu Asp Arg Leu Gly Lys Gln Cys Leu Leu Leu 
1               5                   10                  15      


Pro Leu Leu Leu Leu Ala Ala Trp Lys Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Met Ala Ser Lys Asp Arg Glu Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Arg Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Leu Phe Pro Val Glu Glu Gln Arg Val Leu Ile Tyr Glu 
    130                 135                 140                 


Ser Arg Leu Pro Asp Ser Val Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Val Gly Ser Asn Ser Ile Leu Thr Tyr Lys Leu Ser Ser Ser Glu 
                165                 170                 175     


Tyr Phe Gly Leu Asp Val Lys Ile Asn Ser Asp Asp Asn Lys Gln Ile 
            180                 185                 190         


Gly Leu Leu Leu Lys Lys Ser Leu Asp Arg Glu Glu Ala Pro Ala His 
        195                 200                 205             


Asn Leu Phe Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Val Thr Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Thr Phe Glu Gln Ser Glu Tyr Glu Val Arg Ile Phe Glu Asn Ala Asp 
                245                 250                 255     


Asn Gly Thr Thr Val Ile Arg Leu Asn Ala Ser Asp Arg Asp Glu Gly 
            260                 265                 270         


Ala Asn Gly Ala Ile Ser Tyr Ser Phe Asn Ser Leu Val Ala Ala Met 
        275                 280                 285             


Val Ile Asp His Phe Ser Ile Asp Arg Asn Thr Gly Glu Ile Val Ile 
    290                 295                 300                 


Arg Gly Asn Leu Asp Phe Glu Gln Glu Asn Leu Tyr Lys Ile Leu Ile 
305                 310                 315                 320 


Asp Ala Thr Asp Lys Gly His Pro Pro Met Ala Gly His Cys Thr Val 
                325                 330                 335     


Leu Val Arg Ile Leu Asp Lys Asn Asp Asn Val Pro Glu Ile Ala Leu 
            340                 345                 350         


Thr Ser Leu Ser Leu Pro Val Arg Glu Asp Ala Gln Phe Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Asn Asp Leu Asp Ser Gly Ala Asn Gly Gln 
    370                 375                 380                 


Val Asn Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Leu Ser Val Glu Val Ala Asp Met 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Ile Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Ala Pro Arg Val Gly Gly Thr Gly Gly Ala 
                565                 570                 575     


Val Ser Glu Leu Val Pro Arg Ser Leu Gly Ala Gly Gln Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Pro Ala Ser Ser Ala Arg Phe Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Val Leu Asp Glu Ala 
625                 630                 635                 640 


Asp Ser Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Val Gly Ala Ala Gly 
        675                 680                 685             


Pro Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Pro Pro Thr Glu Gly Ala Cys Thr Ala Asp Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Gln Arg Val Cys Ser Gly Glu Gly Pro Pro Lys Met Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Ser Pro Cys Pro Ile Met Met Gly 
    770                 775                 780                 


Lys Ala Glu Asn Gln Asp Leu Asn Glu Asp His Asp Ala Lys Val Ser 
785                 790                 795                 800 


Glu Phe Ser 
            


<210>  5239
<211>  686
<212>  PRT
<213>  Homo sapiens

<400>  5239

Met Val Phe Thr Pro Glu Asp Arg Leu Gly Lys Gln Cys Leu Leu Leu 
1               5                   10                  15      


Pro Leu Leu Leu Leu Ala Ala Trp Lys Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Met Ala Ser Lys Asp Arg Glu Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Arg Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Leu Phe Pro Val Glu Glu Gln Arg Val Leu Ile Tyr Glu 
    130                 135                 140                 


Ser Arg Leu Pro Asp Ser Val Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Val Gly Ser Asn Ser Ile Leu Thr Tyr Lys Leu Ser Ser Ser Glu 
                165                 170                 175     


Tyr Phe Gly Leu Asp Val Lys Ile Asn Ser Asp Asp Asn Lys Gln Ile 
            180                 185                 190         


Gly Leu Leu Leu Lys Lys Ser Leu Asp Arg Glu Glu Ala Pro Ala His 
        195                 200                 205             


Asn Leu Phe Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Val Thr Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Thr Phe Glu Gln Ser Glu Tyr Glu Val Arg Ile Phe Glu Asn Ala Asp 
                245                 250                 255     


Asn Gly Thr Thr Val Ile Arg Leu Asn Ala Ser Asp Arg Asp Glu Gly 
            260                 265                 270         


Ala Asn Gly Ala Ile Ser Tyr Ser Phe Asn Ser Leu Val Ala Ala Met 
        275                 280                 285             


Val Ile Asp His Phe Ser Ile Asp Arg Asn Thr Gly Glu Ile Val Ile 
    290                 295                 300                 


Arg Gly Asn Leu Asp Phe Glu Gln Glu Asn Leu Tyr Lys Ile Leu Ile 
305                 310                 315                 320 


Asp Ala Thr Asp Lys Gly His Pro Pro Met Ala Gly His Cys Thr Val 
                325                 330                 335     


Leu Val Arg Ile Leu Asp Lys Asn Asp Asn Val Pro Glu Ile Ala Leu 
            340                 345                 350         


Thr Ser Leu Ser Leu Pro Val Arg Glu Asp Ala Gln Phe Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Asn Asp Leu Asp Ser Gly Ala Asn Gly Gln 
    370                 375                 380                 


Val Asn Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Leu Ser Val Glu Val Ala Asp Met 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Ile Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Pro Arg Gln Pro Asn Pro Asp Trp Arg Tyr 
    530                 535                 540                 


Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser Val His Leu Glu Glu 
545                 550                 555                 560 


Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro Asp Gln Gln Trp Pro 
                565                 570                 575     


Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala Gly Glu Val Ser Pro 
            580                 585                 590         


Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr Gly 
        595                 600                 605             


Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys Phe 
    610                 615                 620                 


Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro Thr 
625                 630                 635                 640 


Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys Glu 
                645                 650                 655     


Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln Glu 
            660                 665                 670         


Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn Ser Asp Gln 
        675                 680                 685     


<210>  5240
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  5240

Met Lys Lys Met Asn His Lys Ser Thr Asp Ser Pro Lys Ala Pro Gln 
1               5                   10                  15      


Leu Arg Gly Gly Val Phe Asp Ile Val Phe Ala Thr Asn Ser Thr Gln 
            20                  25                  30          


Val Ile Lys Met Ile Leu Asn Ser Ser Thr Glu Asp Gly Ile Lys Arg 
        35                  40                  45              


Ile Gln Asp Asp Cys Pro Lys Ala Gly Arg His Asn Tyr Ile Phe Val 
    50                  55                  60                  


Met Ile Pro Thr Leu Tyr Ser Ile Ile Phe Val Val Gly Ile Phe Gly 
65                  70                  75                  80  


Asn Ser Leu Val Val Ile Val Ile Tyr Phe Tyr Met Lys Leu Lys Thr 
                85                  90                  95      


Val Ala Ser Val Phe Leu Leu Asn Leu Ala Leu Ala Asp Leu Cys Phe 
            100                 105                 110         


Leu Leu Thr Leu Pro Leu Trp Ala Val Tyr Thr Ala Met Glu Tyr Arg 
        115                 120                 125             


Trp Pro Phe Gly Asn Tyr Leu Cys Lys Ile Ala Ser Ala Ser Val Ser 
    130                 135                 140                 


Phe Asn Leu Tyr Ala Ser Val Phe Leu Leu Thr Cys Leu Ser Ile Asp 
145                 150                 155                 160 


Arg Tyr Leu Ala Ile Val His Pro Met Lys Ser Arg Leu Arg Arg Thr 
                165                 170                 175     


Met Leu Val Ala Lys Val Thr Cys Ile Ile Ile Trp Leu Leu Ala Gly 
            180                 185                 190         


Leu Ala Ser Leu Pro Ala Ile Ile His Arg Asn Val Phe Phe Ile Glu 
        195                 200                 205             


Asn Thr Asn Ile Thr Val Cys Ala Phe His Tyr Glu Ser Gln Asn Ser 
    210                 215                 220                 


Thr Leu Pro Ile Gly Leu Gly Leu Thr Lys Asn Ile Leu Gly Phe Leu 
225                 230                 235                 240 


Phe Pro Phe Leu Ile Ile Leu Thr Ser Tyr Thr Leu Ile Trp Lys Ala 
                245                 250                 255     


Leu Lys Lys Ala Tyr Glu Ile Gln Lys Asn Lys Pro Arg Asn Asp Asp 
            260                 265                 270         


Ile Phe Lys Ile Ile Met Ala Ile Val Leu Phe Phe Phe Phe Ser Trp 
        275                 280                 285             


Ile Pro His Gln Ile Phe Thr Phe Leu Asp Val Leu Ile Gln Leu Gly 
    290                 295                 300                 


Ile Ile Arg Asp Cys Arg Ile Ala Asp Ile Val Asp Thr Ala Met Pro 
305                 310                 315                 320 


Ile Thr Ile Cys Ile Ala Tyr Phe Asn Asn Cys Leu Asn Pro Leu Phe 
                325                 330                 335     


Tyr Gly Phe Leu Gly Lys Lys Phe Lys Arg Tyr Phe Leu Gln Leu Leu 
            340                 345                 350         


Lys Tyr Ile Pro Pro Lys Ala Lys Ser His Ser Asn Leu Ser Thr Lys 
        355                 360                 365             


Met Ser Thr Leu Ser Tyr Arg Pro Ser Asp Asn Val Ser Ser Ser Thr 
    370                 375                 380                 


Lys Lys Pro Ala Pro Cys Phe Glu Val Glu 
385                 390                 


<210>  5241
<211>  814
<212>  PRT
<213>  Homo sapiens

<400>  5241

Met Asp Tyr His Trp Arg Gly Glu Leu Gly Ser Trp Arg Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ala Ala Trp Lys Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Arg His Arg Asp Leu Leu Glu Val Ser Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Val Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Arg Val Lys Asp Gln Lys Leu Phe Val Ser Glu 
    130                 135                 140                 


Ser Arg Met Pro Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Val Gly Ala Asn Ser Val Leu Thr Tyr Arg Leu Ser Ser His Asp 
                165                 170                 175     


Tyr Phe Met Leu Asp Val Asn Ser Lys Asn Asp Glu Asn Lys Leu Val 
            180                 185                 190         


Glu Leu Val Leu Arg Lys Ser Leu Asp Arg Glu Asp Ala Pro Ala His 
        195                 200                 205             


His Leu Phe Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Val Thr Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Thr Phe Glu Gln Ser Glu Tyr Glu Val Arg Ile Phe Glu Asn Ala Asp 
                245                 250                 255     


Asn Gly Thr Thr Val Ile Lys Leu Asn Ala Ser Asp Pro Asp Glu Gly 
            260                 265                 270         


Ala Asn Gly Ala Ile Ser Tyr Ser Phe Asn Ser Leu Val Glu Thr Met 
        275                 280                 285             


Val Ile Asp His Phe Ser Ile Asp Arg Asn Thr Gly Glu Ile Val Ile 
    290                 295                 300                 


Arg Gly Asn Leu Asp Phe Glu Gln Glu Asn Leu Tyr Lys Ile Leu Ile 
305                 310                 315                 320 


Asp Ala Thr Asp Lys Gly His Pro Pro Met Ala Gly His Cys Thr Val 
                325                 330                 335     


Leu Val Arg Ile Leu Asp Lys Asn Asp Asn Val Pro Glu Ile Ala Leu 
            340                 345                 350         


Thr Ser Leu Ser Leu Pro Val Arg Glu Asp Ala Gln Phe Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Asn Asp Leu Asp Ser Gly Ala Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Ser Leu Met Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Arg Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Leu Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ser Leu Ser Ser Tyr Ile Ser Val His Thr 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Glu Pro Arg Val Gly Gly Thr Gly Gly Ala 
                565                 570                 575     


Ala Ser Lys Leu Val Pro Arg Ser Val Gly Ala Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Ala Ala Ser Ser Pro Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Val Leu Asp Glu Ala 
625                 630                 635                 640 


Asp Ser Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Gln Ser Ala Gly Val Leu Gly 
        675                 680                 685             


Pro Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Leu Pro Thr Glu Gly Gly Cys Arg Ala Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Gln Pro Gln Arg Val Cys Ser Gly Glu Gly Pro Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Cys Leu Pro Pro Asp Leu Gly Ser Val Asp 
    770                 775                 780                 


Val Gly Glu Glu Gln Asp Leu Asn Val Asp His Gly Leu Lys Val Ser 
785                 790                 795                 800 


Pro Phe Lys Phe Arg Thr His Lys Phe Tyr Leu Trp Lys Leu 
                805                 810                 


<210>  5242
<211>  950
<212>  PRT
<213>  Homo sapiens

<400>  5242

Met Leu Tyr Ser Ser Arg Gly Asp Pro Glu Gly Gln Pro Leu Leu Leu 
1               5                   10                  15      


Ser Leu Leu Ile Leu Ala Met Trp Val Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Glu His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Gln Leu Asp Ser Lys Gly Arg Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Pro Ala Thr Gln Lys Asn Leu Phe Ile Ala Glu 
    130                 135                 140                 


Ser Arg Pro Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Glu Asn Ala Leu Leu Thr Tyr Arg Leu Ser Pro Asn Glu 
                165                 170                 175     


Tyr Phe Phe Leu Asp Val Pro Thr Ser Asn Gln Gln Val Lys Pro Leu 
            180                 185                 190         


Gly Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Glu Thr Pro Glu Leu 
        195                 200                 205             


His Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Ile Thr Val Leu Asp Asn Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Val Phe Asp Arg Thr Leu Tyr Thr Val Lys Leu Pro Glu Asn Val Ser 
                245                 250                 255     


Ile Gly Thr Leu Val Ile His Pro Asn Ala Ser Asp Leu Asp Glu Gly 
            260                 265                 270         


Leu Asn Gly Asp Ile Ile Tyr Ser Phe Ser Ser Asp Val Ser Pro Asp 
        275                 280                 285             


Ile Lys Ser Lys Phe His Met Asp Pro Leu Ser Gly Ala Ile Thr Val 
    290                 295                 300                 


Ile Gly His Met Asp Phe Glu Glu Ser Arg Ala His Lys Ile Pro Val 
305                 310                 315                 320 


Glu Ala Val Asp Lys Gly Phe Pro Pro Leu Ala Gly His Cys Thr Leu 
                325                 330                 335     


Leu Val Glu Val Val Asp Val Asn Asp Asn Ala Pro Gln Leu Thr Ile 
            340                 345                 350         


Lys Thr Leu Ser Val Pro Val Lys Glu Asp Ala Gln Leu Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Ile Asp Leu Asp Ala Asp Ala Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Tyr Lys Asn Tyr Tyr Ser Leu Val Leu Asp Arg Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Arg Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Ser Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Leu Gly Glu Arg Ser Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Thr Pro Arg Met Arg Gly Thr Asp Gly Ala 
                565                 570                 575     


Val Ser Glu Met Val Leu Arg Ser Val Gly Ala Gly Val Val Val Gly 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Glu Thr Ala Ser Ala Ser Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr 
625                 630                 635                 640 


Asp Ala Pro Arg Gln Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ser Ser Ser Arg Ala Ser Val Gly Ala Thr Gly 
        675                 680                 685             


Pro Glu Val Thr Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Val 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Met Pro Thr Glu Gly Glu Cys Ala Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Gln Arg Val Cys Ser Gly Glu Gly Lys Gln Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Gly Leu Ser Pro Cys Ala Gly Ser Thr Glu 
    770                 775                 780                 


Arg Thr Gly Glu Pro Ser Ala Ser Ser Asp Ser Thr Gly Lys Pro Arg 
785                 790                 795                 800 


Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met 
                805                 810                 815     


His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro 
            820                 825                 830         


Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu 
        835                 840                 845             


Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser 
    850                 855                 860                 


Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly 
865                 870                 875                 880 


Pro Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile 
                885                 890                 895     


Ile Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp 
            900                 905                 910         


Phe Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Lys Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr 
    930                 935                 940                 


Thr Asp Asn Ser Asp Gln 
945                 950 


<210>  5243
<211>  844
<212>  PRT
<213>  Homo sapiens

<400>  5243

Met Val Ser Arg Cys Ser Cys Leu Gly Val Gln Cys Leu Leu Leu Ser 
1               5                   10                  15      


Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His Tyr 
            20                  25                  30          


Ser Val Tyr Glu Glu Ala Arg His Gly Thr Phe Val Gly Arg Ile Ala 
        35                  40                  45              


Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Gln Arg Leu Phe Arg 
    50                  55                  60                  


Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln Asn 
65                  70                  75                  80  


Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys Gly 
                85                  90                  95      


Arg Ser Val Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg Pro 
            100                 105                 110         


Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp Asn 
        115                 120                 125             


Pro Pro Arg Phe Ser Val Thr Glu Gln Lys Leu Ser Ile Pro Glu Ser 
    130                 135                 140                 


Arg Leu Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala Asp 
145                 150                 155                 160 


Val Gly Glu Asn Ala Leu Leu Thr Tyr Lys Leu Ser Pro Asn Glu Tyr 
                165                 170                 175     


Phe Val Leu Asp Ile Ile Asn Lys Lys Asp Lys Asp Lys Phe Pro Val 
            180                 185                 190         


Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Glu Asn Pro Gln Leu Lys 
        195                 200                 205             


Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Phe Thr Gly Ser 
    210                 215                 220                 


Val Ser Leu Leu Ile Leu Val Leu Asp Ala Asn Asp Asn Ala Pro Ile 
225                 230                 235                 240 


Phe Asp Arg Pro Val Tyr Glu Val Lys Met Tyr Glu Asn Gln Val Asn 
                245                 250                 255     


Gln Thr Leu Val Ile Arg Leu Asn Ala Ser Asp Ser Asp Glu Gly Ile 
            260                 265                 270         


Asn Lys Glu Met Met Tyr Ser Phe Ser Ser Leu Val Pro Pro Thr Ile 
        275                 280                 285             


Arg Arg Lys Phe Trp Ile Asn Glu Arg Thr Gly Glu Ile Lys Val Asn 
    290                 295                 300                 


Asp Ala Ile Asp Phe Glu Asp Ser Asn Thr Tyr Glu Ile His Val Asp 
305                 310                 315                 320 


Val Thr Asp Lys Gly Asn Pro Pro Met Val Gly His Cys Thr Val Leu 
                325                 330                 335     


Val Glu Leu Leu Asp Glu Asn Asp Asn Ser Pro Glu Val Ile Val Thr 
            340                 345                 350         


Ser Leu Ser Leu Pro Val Lys Glu Asp Ala Gln Val Gly Thr Val Ile 
        355                 360                 365             


Ala Leu Ile Ser Val Ser Asp His Asp Ser Gly Ala Asn Gly Gln Val 
    370                 375                 380                 


Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr Tyr 
385                 390                 395                 400 


Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu Arg 
                405                 410                 415     


Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser Pro 
            420                 425                 430         


Pro Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Ala Phe Ala Gln Ser Glu Tyr Thr Val Phe Val Lys 
    450                 455                 460                 


Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp Asp 
465                 470                 475                 480 


Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu Arg 
                485                 490                 495     


Arg Leu Gly Glu Arg Ser Leu Ser Ser Tyr Val Ser Val His Ala Glu 
            500                 505                 510         


Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu Glu 
        515                 520                 525             


Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Gly Gly Val Pro Pro Leu 
    530                 535                 540                 


Gly Ser Asn Leu Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Leu Leu Ala Ser Pro Ala Gly Ser Ala Gly Gly Ala Val 
                565                 570                 575     


Ser Glu Leu Val Leu Arg Ser Val Val Ala Gly His Val Val Ala Lys 
            580                 585                 590         


Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Glu Leu Gln Ser Ala Ala Val Gly Ala Arg Ile Pro Phe Arg Val Gly 
    610                 615                 620                 


Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr Asp 
625                 630                 635                 640 


Ser Pro Arg Gln Arg Leu Leu Val Leu Val Lys Asp His Gly Glu Pro 
                645                 650                 655     


Ser Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Gly Ser 
            660                 665                 670         


Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Val Gly Val Ala Pro Glu 
        675                 680                 685             


Val Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile Cys Ala 
    690                 695                 700                 


Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala Leu Arg 
705                 710                 715                 720 


Cys Ser Ala Ala Pro Thr Glu Gly Ala Cys Gly Pro Val Lys Pro Thr 
                725                 730                 735     


Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln Gln Arg 
            740                 745                 750         


Arg Gln Arg Val Cys Ser Gly Glu Gly Leu Pro Lys Ala Asp Leu Met 
        755                 760                 765             


Ala Phe Ser Pro Ser Leu Pro Pro Cys Pro Met Val Asp Val Asp Gly 
    770                 775                 780                 


Glu Asp Gln Ser Ile Gly Gly Asp His Ser Arg Lys Val Gly Tyr Tyr 
785                 790                 795                 800 


Val Phe Ile Phe Leu Leu Cys Phe Met Asn Asn Ile Phe Ser Tyr Arg 
                805                 810                 815     


Ile Phe Ser Asn Met Tyr Gln Asn Ile Ser Phe Leu Ser Thr Phe His 
            820                 825                 830         


Leu Cys Leu Asn Ile Ser Ser Asp Thr Phe Val Ile 
        835                 840                 


<210>  5244
<211>  1007
<212>  PRT
<213>  Homo sapiens

<400>  5244

Met Glu Gln Ala Gly Thr Arg Pro Ala Ala Thr Glu His Pro Arg Leu 
1               5                   10                  15      


Arg Arg Pro Met Pro Trp Leu Leu Leu Leu Pro Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Pro Gly Pro Ala Ala Ser Gln Leu Arg Tyr Ser Val 
        35                  40                  45              


Pro Glu Glu Gln Ala Pro Gly Ala Leu Val Gly Asn Val Ala Arg Ala 
    50                  55                  60                  


Leu Gly Leu Glu Leu Arg Arg Leu Gly Pro Gly Cys Leu Arg Ile Asn 
65                  70                  75                  80  


His Leu Gly Ala Pro Ser Pro Arg Tyr Leu Glu Leu Asp Leu Thr Ser 
                85                  90                  95      


Gly Ala Leu Phe Val Asn Glu Arg Ile Asp Arg Glu Ala Leu Cys Glu 
            100                 105                 110         


Gln Arg Pro Arg Cys Leu Leu Ser Leu Glu Val Leu Ala His Asn Pro 
        115                 120                 125             


Val Ala Val Ser Ala Val Glu Val Glu Ile Leu Asp Ile Asn Asp Asn 
    130                 135                 140                 


Ser Pro Arg Phe Pro Arg Pro Asn Tyr Gln Leu Gln Val Ser Glu Ser 
145                 150                 155                 160 


Val Ala Pro Gly Ala Arg Phe His Ile Glu Ser Ala Gln Asp Pro Asp 
                165                 170                 175     


Val Gly Ala Asn Ser Val Gln Thr Tyr Glu Leu Ser Pro Ser Glu His 
            180                 185                 190         


Phe Glu Leu Asp Leu Lys Pro Leu Gln Glu Asn Ser Lys Val Leu Glu 
        195                 200                 205             


Leu Val Leu Arg Lys Gly Leu Asp Arg Glu Gln Ala Ala Leu His His 
    210                 215                 220                 


Leu Val Leu Thr Ala Val Asp Gly Gly Ile Pro Ala Arg Ser Gly Thr 
225                 230                 235                 240 


Ala Gln Ile Ser Val Arg Val Leu Asp Thr Asn Asp Asn Ser Pro Ala 
                245                 250                 255     


Phe Asp Gln Ser Thr Tyr Arg Val Gln Leu Arg Glu Asp Ser Pro Pro 
            260                 265                 270         


Gly Thr Leu Val Val Lys Leu Asn Ala Ser Asp Pro Asp Glu Gly Ser 
        275                 280                 285             


Asn Gly Glu Leu Arg Tyr Ser Leu Ser Ser Tyr Thr Ser Asp Arg Glu 
    290                 295                 300                 


Arg Gln Leu Phe Ser Ile Asp Ala Ser Thr Gly Glu Val Arg Val Ile 
305                 310                 315                 320 


Gly Gly Leu Asp Tyr Glu Glu Ala Ser Ser Tyr Gln Ile Tyr Val Gln 
                325                 330                 335     


Ala Thr Asp Arg Gly Pro Val Pro Met Ala Gly His Cys Lys Val Leu 
            340                 345                 350         


Val Asp Ile Val Asp Val Asn Asp Asn Ala Pro Glu Val Val Leu Thr 
        355                 360                 365             


Asp Leu Tyr Ser Pro Val Pro Glu Asn Ala Thr Pro Asn Thr Ile Val 
    370                 375                 380                 


Ala Val Leu Ser Val Asn Asp Gln Asp Ser Gly Pro Asn Arg Lys Val 
385                 390                 395                 400 


Ser Leu Gly Leu Glu Ala Thr Leu Pro Phe Arg Leu Asn Gly Phe Gly 
                405                 410                 415     


Asn Ser Tyr Thr Leu Val Val Ser Gly Pro Leu Asp Arg Glu Arg Val 
            420                 425                 430         


Ala Val Tyr Asn Ile Thr Val Thr Ala Thr Asp Gly Gly Ile Pro Gln 
        435                 440                 445             


Leu Thr Ser Leu Arg Thr Leu Lys Val Glu Ile Ser Asp Ile Asn Asp 
    450                 455                 460                 


Asn Pro Pro Ser Phe Leu Glu Asp Ser Tyr Ser Ile Tyr Ile Gln Glu 
465                 470                 475                 480 


Asn Asn Leu Pro Gly Val Leu Leu Cys Thr Val Gln Ala Thr Asp Pro 
                485                 490                 495     


Asp Glu Lys Glu Asn Ala Glu Val Thr Tyr Ser Leu Leu Glu Arg Glu 
            500                 505                 510         


Ile Gln Gly Leu Pro Val Thr Ser Tyr Val Ser Ile Asn Ser Ala Ser 
        515                 520                 525             


Gly Ser Leu Tyr Ala Val Asn Ser Phe Asp Tyr Glu Lys Phe Arg Glu 
    530                 535                 540                 


Phe Phe Val Thr Val Glu Ala Gln Asp Lys Gly Ser Pro Pro Leu Ser 
545                 550                 555                 560 


Ser Thr Val Thr Ala Asn Val Tyr Val Val Asp Met Asn Asp His Ala 
                565                 570                 575     


Pro His Ile Leu Tyr Pro Thr Ser Thr Asn Ser Ser Ala Ala Phe Glu 
            580                 585                 590         


Met Val Pro Arg Thr Ala Pro Ala Gly Tyr Leu Val Thr Lys Val Ile 
        595                 600                 605             


Ala Met Asp Ser Asp Ser Gly Gln Asn Ala Trp Leu Phe Tyr His Leu 
    610                 615                 620                 


Ala Gln Thr Ser Asp Leu Asp Leu Phe Lys Val Glu Leu His Thr Gly 
625                 630                 635                 640 


Glu Ile Arg Thr Thr Arg Lys Met Gly Asp Glu Ser Gly Ser Thr Phe 
                645                 650                 655     


Asn Leu Thr Val Val Val Arg Asp Asn Gly Glu Pro Ser Leu Ser Ala 
            660                 665                 670         


Ser Val Ala Ile Thr Val Ala Val Val Asp Arg Val Ser Lys Ile Leu 
        675                 680                 685             


Pro Asp Thr Gln Arg His Val Lys Ser Pro Arg Thr Tyr Ser Glu Ile 
    690                 695                 700                 


Thr Leu Tyr Leu Ile Ile Ala Leu Ser Thr Val Ser Phe Ile Phe Leu 
705                 710                 715                 720 


Leu Thr Ile Ile Ile Leu Ser Ile Ile Lys Cys Tyr Arg Tyr Thr Ala 
                725                 730                 735     


Tyr Gly Thr Ala Cys Cys Gly Gly Phe Cys Gly Val Arg Glu Arg Ser 
            740                 745                 750         


Pro Ala Glu Leu Tyr Lys Gln Ala Asn Asn Asn Ile Asp Ala Arg Ile 
        755                 760                 765             


Pro His Gly Leu Lys Val Gln Pro His Phe Ile Glu Val Arg Gly Asn 
    770                 775                 780                 


Gly Ser Leu Thr Lys Thr Tyr Cys Tyr Lys Ala Cys Leu Thr Ala Gly 
785                 790                 795                 800 


Ser Gly Ser Asp Thr Phe Met Phe Tyr Asn Thr Gly Ala Gln Thr Gly 
                805                 810                 815     


Pro Gly Pro Ser Gly Ala Gln Ala Ala Val Thr Asp Ser Arg Asn Leu 
            820                 825                 830         


Thr Gly Gln Ser Gly Gln Asn Ala Gly Asn Leu Ile Ile Leu Lys Asn 
        835                 840                 845             


Glu Ala Val Ser Gln Asn Glu Pro Arg Gln Pro Asn Pro Asp Trp Arg 
    850                 855                 860                 


Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser Val His Leu Glu 
865                 870                 875                 880 


Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro Asp Gln Gln Trp 
                885                 890                 895     


Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala Gly Glu Val Ser 
            900                 905                 910         


Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr 
        915                 920                 925             


Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys 
    930                 935                 940                 


Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro 
945                 950                 955                 960 


Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys 
                965                 970                 975     


Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln 
            980                 985                 990         


Glu Lys Lys Glu Lys Gly Asn Ser  Thr Thr Asp Asn Ser  Asp Gln 
        995                 1000                 1005         


<210>  5245
<211>  963
<212>  PRT
<213>  Homo sapiens

<400>  5245

Met Val Gly Cys Gly Val Ala Val Leu Cys Leu Trp Val Ser Cys Gly 
1               5                   10                  15      


Ala Ala Ala Gly Gln Leu Glu Tyr Ser Val Pro Glu Glu Thr Glu Arg 
            20                  25                  30          


Gly Val Ala Val Gly Asn Leu Ser Ala Asp Leu Arg Leu Pro Ala Ala 
        35                  40                  45              


Ala Met Ser Ser Arg Asn Phe Arg Phe Leu Ser Ser His Arg Glu Leu 
    50                  55                  60                  


Tyr Phe Gly Val Asp Leu Pro Ser Gly Asn Leu Val Val Arg Glu Pro 
65                  70                  75                  80  


Ala Asp Arg Glu Gln Leu Cys Arg Ala Lys Ala Ala Cys Val Leu Thr 
                85                  90                  95      


Tyr Asp Leu Val Leu Glu Asp Pro Leu Glu Leu His Lys Ile Arg Ile 
            100                 105                 110         


His Val Leu Asp Thr Asn Asp Asn Ser Pro Leu Phe Pro Ala Gly Asp 
        115                 120                 125             


Val Gln Leu His Ile Pro Glu Phe Leu Thr Pro Gly Ala Arg Phe Thr 
    130                 135                 140                 


Leu Pro Asn Ala Gln Asp Asp Asp Glu Gly Ser Asn Gly Ile Leu Ser 
145                 150                 155                 160 


Tyr Ser Leu Ser Pro Ser Gln His Phe Arg Leu Asp Met Gly Ser Arg 
                165                 170                 175     


Val Asp Gly Ser Glu Tyr Pro Glu Leu Val Leu Glu Lys Ala Leu Asp 
            180                 185                 190         


Arg Glu Gln Arg Ala Thr His Leu Leu Val Leu Thr Ala Arg Asp Gly 
        195                 200                 205             


Gly Leu Pro Ala Arg Ser Gly Asp Ala Gln Val Thr Ile Ile Val Val 
    210                 215                 220                 


Asp Thr Asn Asp Asn Ala Pro Val Phe Glu Arg Ser Val Tyr Arg Thr 
225                 230                 235                 240 


Lys Val Pro Glu Thr Ala Pro Asn Gly Thr Val Leu Phe Arg Val Gln 
                245                 250                 255     


Ala Leu Asp Pro Asp Glu Gly Ser Asn Gly Glu Val Gln Tyr Ser Leu 
            260                 265                 270         


Ser Asn Ser Thr Gln Ala Glu Leu Arg His Arg Phe His Val His Pro 
        275                 280                 285             


Lys Ser Gly Glu Val Gln Val Ala Ala Ser Leu Gly Pro Pro Glu Thr 
    290                 295                 300                 


Leu Leu Glu Ala Tyr Ile Glu Ala Arg Asp Glu Gly Val Phe Gly Leu 
305                 310                 315                 320 


Ala Ser Thr Ala Lys Leu Leu Val Glu Val Thr Asp Val Asn Asp His 
                325                 330                 335     


Ala Pro Glu Leu Asp Phe Leu Thr Leu Ser Asn Pro Val Pro Glu Asp 
            340                 345                 350         


Ala Ala Pro Gly Thr Val Ile Ala Leu Phe Ser Val Lys Asp Glu Asp 
        355                 360                 365             


Leu Asp Ser Asn Gly Arg Val Ile Cys Gly Met Ser Ser Ala Gly Pro 
    370                 375                 380                 


Phe Gln Leu Thr Ala Ser Phe Asp Asn Tyr Tyr Ser Leu Leu Ile Asp 
385                 390                 395                 400 


Gly Pro Leu Asp Arg Glu Gln Ile Ser Glu Tyr Gln Val Leu Ile Thr 
                405                 410                 415     


Ala Ser Asp Ser Gly Ser Pro Pro Leu Ser Thr Arg Arg Thr Ile Thr 
            420                 425                 430         


Val Ser Val Ala Asp Val Asn Asp Asn Thr Pro Asn Phe Pro Gln Pro 
        435                 440                 445             


Gln Gln Glu Leu Phe Val Ala Glu Asn Asn Gly Pro Gly Ala Ser Leu 
    450                 455                 460                 


Gly Arg Val Phe Ala Gln Asp Pro Asp Leu Gly Lys Asn Gly Leu Val 
465                 470                 475                 480 


Ser Tyr Glu Leu Leu Asp Val Ile Ser Glu Gly Pro Ser Ala Ser Ser 
                485                 490                 495     


Leu Leu Ala Val Glu Ser Ser Ser Gly Ala Ile Thr Ala Lys Thr Ser 
            500                 505                 510         


Phe Asp Phe Glu Gln Leu Arg Gly Phe His Phe Gln Val Glu Gly Arg 
        515                 520                 525             


Asp Gly Gly Ile Pro Pro Arg Ser Ala Thr Val Thr Ile Asn Leu Phe 
    530                 535                 540                 


Val Val Asp Arg Asn Asp Asn Tyr Pro Val Ile Leu Phe Pro Leu Pro 
545                 550                 555                 560 


Arg Asn Gly Ser Val Pro Val Glu Ile Val Pro Arg Ser Ala Arg Thr 
                565                 570                 575     


Gly His Leu Val Thr Lys Val Val Ala Glu Asp Ala Asp Ser Gly Ser 
            580                 585                 590         


Asn Ala Trp Leu Ser Tyr His Ile Ser Arg Ala Ser Asp Ser Ser Leu 
        595                 600                 605             


Phe Arg Ile Ser Ala Asn Ile Gly Glu Leu Arg Thr Ala Arg Leu Val 
    610                 615                 620                 


Leu Pro Thr Asp Ala Val Lys Gln Arg Val Val Val Val Val Arg Asp 
625                 630                 635                 640 


His Gly Asp Pro Pro Leu Ser Ser Ser Val Thr Leu Gly Val Leu Leu 
                645                 650                 655     


Ser Asn Ser Val Pro Gln Leu Leu Pro Asp Phe Glu Asp Val Trp Glu 
            660                 665                 670         


Pro Gly Gly Gln Leu Ser Ala Gln Asn Leu Tyr Leu Val Ile Ala Leu 
        675                 680                 685             


Ala Cys Ile Ser Phe Leu Phe Leu Gly Cys Leu Leu Phe Phe Val Cys 
    690                 695                 700                 


Thr Lys Leu His Gln Ser Pro Gly Cys Cys Ala Gln Ser Cys Cys Arg 
705                 710                 715                 720 


Ser Thr Glu Asp Leu Arg Tyr Gly Ser Lys Met Val Ser Asn Pro Cys 
                725                 730                 735     


Met Thr Ser Ala Thr Ile Asp Val Thr Thr Val Glu Arg Leu Ser Gln 
            740                 745                 750         


Thr Tyr Leu Tyr Arg Ala Ser Leu Gly Leu Gly Ser Asp Asn Asn Ser 
        755                 760                 765             


Leu Leu Leu Arg Gly Glu Tyr Asn Ala Ala Asp Leu Arg Asn Leu Ala 
    770                 775                 780                 


Thr Gly Val Gly Leu Asn Leu Pro Ile Ser Cys Ile Gln Ile Arg Asn 
785                 790                 795                 800 


Arg Lys Gly Asp His Ala Asn Val Asn Ala Met Pro Arg Gln Pro Asn 
                805                 810                 815     


Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser 
            820                 825                 830         


Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro 
        835                 840                 845             


Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala 
    850                 855                 860                 


Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp 
865                 870                 875                 880 


Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu 
                885                 890                 895     


Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile 
            900                 905                 910         


Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr 
        915                 920                 925             


Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly 
    930                 935                 940                 


Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn 
945                 950                 955                 960 


Ser Asp Gln 
            


<210>  5246
<211>  844
<212>  PRT
<213>  Homo sapiens

<400>  5246

Met Val Ser Arg Cys Ser Cys Leu Gly Val Gln Cys Leu Leu Leu Ser 
1               5                   10                  15      


Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His Tyr 
            20                  25                  30          


Ser Val Tyr Glu Glu Ala Arg His Gly Thr Phe Val Gly Arg Ile Ala 
        35                  40                  45              


Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Gln Arg Leu Phe Arg 
    50                  55                  60                  


Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln Asn 
65                  70                  75                  80  


Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys Gly 
                85                  90                  95      


Arg Ser Val Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg Pro 
            100                 105                 110         


Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp Asn 
        115                 120                 125             


Pro Pro Arg Phe Ser Val Thr Glu Gln Lys Leu Ser Ile Pro Glu Ser 
    130                 135                 140                 


Arg Leu Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala Asp 
145                 150                 155                 160 


Val Gly Glu Asn Ala Leu Leu Thr Tyr Lys Leu Ser Pro Asn Glu Tyr 
                165                 170                 175     


Phe Val Leu Asp Ile Ile Asn Lys Lys Asp Lys Asp Lys Phe Pro Val 
            180                 185                 190         


Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Glu Asn Pro Gln Leu Lys 
        195                 200                 205             


Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Phe Thr Gly Ser 
    210                 215                 220                 


Val Ser Leu Leu Ile Leu Val Leu Asp Ala Asn Asp Asn Ala Pro Ile 
225                 230                 235                 240 


Phe Asp Arg Pro Val Tyr Glu Val Lys Met Tyr Glu Asn Gln Val Asn 
                245                 250                 255     


Gln Thr Leu Val Ile Arg Leu Asn Ala Ser Asp Ser Asp Glu Gly Ile 
            260                 265                 270         


Asn Lys Glu Met Met Tyr Ser Phe Ser Ser Leu Val Pro Pro Thr Ile 
        275                 280                 285             


Arg Arg Lys Phe Trp Ile Asn Glu Arg Thr Gly Glu Ile Lys Val Asn 
    290                 295                 300                 


Asp Ala Ile Asp Phe Glu Asp Ser Asn Thr Tyr Glu Ile His Val Asp 
305                 310                 315                 320 


Val Thr Asp Lys Gly Asn Pro Pro Met Val Gly His Cys Thr Val Leu 
                325                 330                 335     


Val Glu Leu Leu Asp Glu Asn Asp Asn Ser Pro Glu Val Ile Val Thr 
            340                 345                 350         


Ser Leu Ser Leu Pro Val Lys Glu Asp Ala Gln Val Gly Thr Val Ile 
        355                 360                 365             


Ala Leu Ile Ser Val Ser Asp His Asp Ser Gly Ala Asn Gly Gln Val 
    370                 375                 380                 


Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr Tyr 
385                 390                 395                 400 


Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu Arg 
                405                 410                 415     


Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser Pro 
            420                 425                 430         


Pro Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Ala Phe Ala Gln Ser Glu Tyr Thr Val Phe Val Lys 
    450                 455                 460                 


Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp Asp 
465                 470                 475                 480 


Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu Arg 
                485                 490                 495     


Arg Leu Gly Glu Arg Ser Leu Ser Ser Tyr Val Ser Val His Ala Glu 
            500                 505                 510         


Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu Glu 
        515                 520                 525             


Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Gly Gly Val Pro Pro Leu 
    530                 535                 540                 


Gly Ser Asn Leu Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Leu Leu Ala Ser Pro Ala Gly Ser Ala Gly Gly Ala Val 
                565                 570                 575     


Ser Glu Leu Val Leu Arg Ser Val Val Ala Gly His Val Val Ala Lys 
            580                 585                 590         


Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Glu Leu Gln Ser Ala Ala Val Gly Ala Arg Ile Pro Phe Arg Val Gly 
    610                 615                 620                 


Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr Asp 
625                 630                 635                 640 


Ser Pro Arg Gln Arg Leu Leu Val Leu Val Lys Asp His Gly Glu Pro 
                645                 650                 655     


Ser Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Gly Ser 
            660                 665                 670         


Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Val Gly Val Ala Pro Glu 
        675                 680                 685             


Val Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile Cys Ala 
    690                 695                 700                 


Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala Leu Arg 
705                 710                 715                 720 


Cys Ser Ala Ala Pro Thr Glu Gly Ala Cys Gly Pro Val Lys Pro Thr 
                725                 730                 735     


Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln Gln Arg 
            740                 745                 750         


Arg Gln Arg Val Cys Ser Gly Glu Gly Leu Pro Lys Ala Asp Leu Met 
        755                 760                 765             


Ala Phe Ser Pro Ser Leu Pro Pro Cys Pro Met Val Asp Val Asp Gly 
    770                 775                 780                 


Glu Asp Gln Ser Ile Gly Gly Asp His Ser Arg Lys Val Gly Tyr Tyr 
785                 790                 795                 800 


Val Phe Ile Phe Leu Leu Cys Phe Met Asn Asn Ile Phe Ser Tyr Arg 
                805                 810                 815     


Ile Phe Ser Asn Met Tyr Gln Asn Ile Ser Phe Leu Ser Thr Phe His 
            820                 825                 830         


Leu Cys Leu Asn Ile Ser Ser Asp Thr Phe Val Ile 
        835                 840                 


<210>  5247
<211>  884
<212>  PRT
<213>  Homo sapiens

<400>  5247

Met Glu Gln Ala Gly Thr Arg Pro Ala Ala Thr Glu His Pro Arg Leu 
1               5                   10                  15      


Arg Arg Pro Met Pro Trp Leu Leu Leu Leu Pro Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Pro Gly Pro Ala Ala Ser Gln Leu Arg Tyr Ser Val 
        35                  40                  45              


Pro Glu Glu Gln Ala Pro Gly Ala Leu Val Gly Asn Val Ala Arg Ala 
    50                  55                  60                  


Leu Gly Leu Glu Leu Arg Arg Leu Gly Pro Gly Cys Leu Arg Ile Asn 
65                  70                  75                  80  


His Leu Gly Ala Pro Ser Pro Arg Tyr Leu Glu Leu Asp Leu Thr Ser 
                85                  90                  95      


Gly Ala Leu Phe Val Asn Glu Arg Ile Asp Arg Glu Ala Leu Cys Glu 
            100                 105                 110         


Gln Arg Pro Arg Cys Leu Leu Ser Leu Glu Val Leu Ala His Asn Pro 
        115                 120                 125             


Val Ala Val Ser Ala Val Glu Val Glu Ile Leu Asp Ile Asn Asp Asn 
    130                 135                 140                 


Ser Pro Arg Phe Pro Arg Pro Asn Tyr Gln Leu Gln Val Ser Glu Ser 
145                 150                 155                 160 


Val Ala Pro Gly Ala Arg Phe His Ile Glu Ser Ala Gln Asp Pro Asp 
                165                 170                 175     


Val Gly Ala Asn Ser Val Gln Thr Tyr Glu Leu Ser Pro Ser Glu His 
            180                 185                 190         


Phe Glu Leu Asp Leu Lys Pro Leu Gln Glu Asn Ser Lys Val Leu Glu 
        195                 200                 205             


Leu Val Leu Arg Lys Gly Leu Asp Arg Glu Gln Ala Ala Leu His His 
    210                 215                 220                 


Leu Val Leu Thr Ala Val Asp Gly Gly Ile Pro Ala Arg Ser Gly Thr 
225                 230                 235                 240 


Ala Gln Ile Ser Val Arg Val Leu Asp Thr Asn Asp Asn Ser Pro Ala 
                245                 250                 255     


Phe Asp Gln Ser Thr Tyr Arg Val Gln Leu Arg Glu Asp Ser Pro Pro 
            260                 265                 270         


Gly Thr Leu Val Val Lys Leu Asn Ala Ser Asp Pro Asp Glu Gly Ser 
        275                 280                 285             


Asn Gly Glu Leu Arg Tyr Ser Leu Ser Ser Tyr Thr Ser Asp Arg Glu 
    290                 295                 300                 


Arg Gln Leu Phe Ser Ile Asp Ala Ser Thr Gly Glu Val Arg Val Ile 
305                 310                 315                 320 


Gly Gly Leu Asp Tyr Glu Glu Ala Ser Ser Tyr Gln Ile Tyr Val Gln 
                325                 330                 335     


Ala Thr Asp Arg Gly Pro Val Pro Met Ala Gly His Cys Lys Val Leu 
            340                 345                 350         


Val Asp Ile Val Asp Val Asn Asp Asn Ala Pro Glu Val Val Leu Thr 
        355                 360                 365             


Asp Leu Tyr Ser Pro Val Pro Glu Asn Ala Thr Pro Asn Thr Ile Val 
    370                 375                 380                 


Ala Val Leu Ser Val Asn Asp Gln Asp Ser Gly Pro Asn Arg Lys Val 
385                 390                 395                 400 


Ser Leu Gly Leu Glu Ala Thr Leu Pro Phe Arg Leu Asn Gly Phe Gly 
                405                 410                 415     


Asn Ser Tyr Thr Leu Val Val Ser Gly Pro Leu Asp Arg Glu Arg Val 
            420                 425                 430         


Ala Val Tyr Asn Ile Thr Val Thr Ala Thr Asp Gly Gly Ile Pro Gln 
        435                 440                 445             


Leu Thr Ser Leu Arg Thr Leu Lys Val Glu Ile Ser Asp Ile Asn Asp 
    450                 455                 460                 


Asn Pro Pro Ser Phe Leu Glu Asp Ser Tyr Ser Ile Tyr Ile Gln Glu 
465                 470                 475                 480 


Asn Asn Leu Pro Gly Val Leu Leu Cys Thr Val Gln Ala Thr Asp Pro 
                485                 490                 495     


Asp Glu Lys Glu Asn Ala Glu Val Thr Tyr Ser Leu Leu Glu Arg Glu 
            500                 505                 510         


Ile Gln Gly Leu Pro Val Thr Ser Tyr Val Ser Ile Asn Ser Ala Ser 
        515                 520                 525             


Gly Ser Leu Tyr Ala Val Asn Ser Phe Asp Tyr Glu Lys Phe Arg Glu 
    530                 535                 540                 


Phe Phe Val Thr Val Glu Ala Gln Asp Lys Gly Ser Pro Pro Leu Ser 
545                 550                 555                 560 


Ser Thr Val Thr Ala Asn Val Tyr Val Val Asp Met Asn Asp His Ala 
                565                 570                 575     


Pro His Ile Leu Tyr Pro Thr Ser Thr Asn Ser Ser Ala Ala Phe Glu 
            580                 585                 590         


Met Val Pro Arg Thr Ala Pro Ala Gly Tyr Leu Val Thr Lys Val Ile 
        595                 600                 605             


Ala Met Asp Ser Asp Ser Gly Gln Asn Ala Trp Leu Phe Tyr His Leu 
    610                 615                 620                 


Ala Gln Thr Ser Asp Leu Asp Leu Phe Lys Val Glu Leu His Thr Gly 
625                 630                 635                 640 


Glu Ile Arg Thr Thr Arg Lys Met Gly Asp Glu Ser Gly Ser Thr Phe 
                645                 650                 655     


Asn Leu Thr Val Val Val Arg Asp Asn Gly Glu Pro Ser Leu Ser Ala 
            660                 665                 670         


Ser Val Ala Ile Thr Val Ala Val Val Asp Arg Val Ser Lys Ile Leu 
        675                 680                 685             


Pro Asp Thr Gln Arg His Val Lys Ser Pro Arg Thr Tyr Ser Glu Ile 
    690                 695                 700                 


Thr Leu Tyr Leu Ile Ile Ala Leu Ser Thr Val Ser Phe Ile Phe Leu 
705                 710                 715                 720 


Leu Thr Ile Ile Ile Leu Ser Ile Ile Lys Cys Tyr Arg Tyr Thr Ala 
                725                 730                 735     


Tyr Gly Thr Ala Cys Cys Gly Gly Phe Cys Gly Val Arg Glu Arg Ser 
            740                 745                 750         


Pro Ala Glu Leu Tyr Lys Gln Ala Asn Asn Asn Ile Asp Ala Arg Ile 
        755                 760                 765             


Pro His Gly Leu Lys Val Gln Pro His Phe Ile Glu Val Arg Gly Asn 
    770                 775                 780                 


Gly Ser Leu Thr Lys Thr Tyr Cys Tyr Lys Ala Cys Leu Thr Ala Gly 
785                 790                 795                 800 


Ser Gly Ser Asp Thr Phe Met Phe Tyr Asn Thr Gly Ala Gln Thr Gly 
                805                 810                 815     


Pro Gly Pro Ser Gly Ala Gln Ala Ala Val Thr Asp Ser Arg Asn Leu 
            820                 825                 830         


Thr Gly Gln Ser Gly Gln Asn Ala Gly Asn Leu Ile Ile Leu Lys Asn 
        835                 840                 845             


Glu Ala Val Ser Gln Asn Glu Val Arg Gln Trp Ser Gly Gly Leu Leu 
    850                 855                 860                 


Gln Thr His Ala Phe Val Thr His Pro Pro Ile Ser Cys Asp Leu Ala 
865                 870                 875                 880 


Leu Leu Ser His 
                


<210>  5248
<211>  685
<212>  PRT
<213>  Homo sapiens

<400>  5248

Met Val Ser Arg Cys Ser Cys Leu Gly Val Gln Cys Leu Leu Leu Ser 
1               5                   10                  15      


Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His Tyr 
            20                  25                  30          


Ser Val Tyr Glu Glu Ala Arg His Gly Thr Phe Val Gly Arg Ile Ala 
        35                  40                  45              


Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Gln Arg Leu Phe Arg 
    50                  55                  60                  


Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln Asn 
65                  70                  75                  80  


Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys Gly 
                85                  90                  95      


Arg Ser Val Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg Pro 
            100                 105                 110         


Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp Asn 
        115                 120                 125             


Pro Pro Arg Phe Ser Val Thr Glu Gln Lys Leu Ser Ile Pro Glu Ser 
    130                 135                 140                 


Arg Leu Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala Asp 
145                 150                 155                 160 


Val Gly Glu Asn Ala Leu Leu Thr Tyr Lys Leu Ser Pro Asn Glu Tyr 
                165                 170                 175     


Phe Val Leu Asp Ile Ile Asn Lys Lys Asp Lys Asp Lys Phe Pro Val 
            180                 185                 190         


Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Glu Asn Pro Gln Leu Lys 
        195                 200                 205             


Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Phe Thr Gly Ser 
    210                 215                 220                 


Val Ser Leu Leu Ile Leu Val Leu Asp Ala Asn Asp Asn Ala Pro Ile 
225                 230                 235                 240 


Phe Asp Arg Pro Val Tyr Glu Val Lys Met Tyr Glu Asn Gln Val Asn 
                245                 250                 255     


Gln Thr Leu Val Ile Arg Leu Asn Ala Ser Asp Ser Asp Glu Gly Ile 
            260                 265                 270         


Asn Lys Glu Met Met Tyr Ser Phe Ser Ser Leu Val Pro Pro Thr Ile 
        275                 280                 285             


Arg Arg Lys Phe Trp Ile Asn Glu Arg Thr Gly Glu Ile Lys Val Asn 
    290                 295                 300                 


Asp Ala Ile Asp Phe Glu Asp Ser Asn Thr Tyr Glu Ile His Val Asp 
305                 310                 315                 320 


Val Thr Asp Lys Gly Asn Pro Pro Met Val Gly His Cys Thr Val Leu 
                325                 330                 335     


Val Glu Leu Leu Asp Glu Asn Asp Asn Ser Pro Glu Val Ile Val Thr 
            340                 345                 350         


Ser Leu Ser Leu Pro Val Lys Glu Asp Ala Gln Val Gly Thr Val Ile 
        355                 360                 365             


Ala Leu Ile Ser Val Ser Asp His Asp Ser Gly Ala Asn Gly Gln Val 
    370                 375                 380                 


Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr Tyr 
385                 390                 395                 400 


Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu Arg 
                405                 410                 415     


Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser Pro 
            420                 425                 430         


Pro Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Ala Phe Ala Gln Ser Glu Tyr Thr Val Phe Val Lys 
    450                 455                 460                 


Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp Asp 
465                 470                 475                 480 


Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu Arg 
                485                 490                 495     


Arg Leu Gly Glu Arg Ser Leu Ser Ser Tyr Val Ser Val His Ala Glu 
            500                 505                 510         


Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu Glu 
        515                 520                 525             


Leu Leu Gln Phe Gln Pro Arg Gln Pro Asn Pro Asp Trp Arg Tyr Ser 
    530                 535                 540                 


Ala Ser Leu Arg Ala Gly Met His Ser Ser Val His Leu Glu Glu Ala 
545                 550                 555                 560 


Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro Asp Gln Gln Trp Pro Thr 
                565                 570                 575     


Val Ser Ser Ala Thr Pro Glu Pro Glu Ala Gly Glu Val Ser Pro Pro 
            580                 585                 590         


Val Gly Ala Gly Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr Gly Pro 
        595                 600                 605             


Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys Phe Ile 
    610                 615                 620                 


Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro Thr Asn 
625                 630                 635                 640 


Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys Glu Glu 
                645                 650                 655     


Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln Glu Lys 
            660                 665                 670         


Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn Ser Asp Gln 
        675                 680                 685 


<210>  5249
<211>  844
<212>  PRT
<213>  Homo sapiens

<400>  5249

Met Val Ser Arg Cys Ser Cys Leu Gly Val Gln Cys Leu Leu Leu Ser 
1               5                   10                  15      


Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His Tyr 
            20                  25                  30          


Ser Val Tyr Glu Glu Ala Arg His Gly Thr Phe Val Gly Arg Ile Ala 
        35                  40                  45              


Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Gln Arg Leu Phe Arg 
    50                  55                  60                  


Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln Asn 
65                  70                  75                  80  


Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys Gly 
                85                  90                  95      


Arg Ser Val Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg Pro 
            100                 105                 110         


Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp Asn 
        115                 120                 125             


Pro Pro Arg Phe Ser Val Thr Glu Gln Lys Leu Ser Ile Pro Glu Ser 
    130                 135                 140                 


Arg Leu Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala Asp 
145                 150                 155                 160 


Val Gly Glu Asn Ala Leu Leu Thr Tyr Lys Leu Ser Pro Asn Glu Tyr 
                165                 170                 175     


Phe Val Leu Asp Ile Ile Asn Lys Lys Asp Lys Asp Lys Phe Pro Val 
            180                 185                 190         


Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Glu Asn Pro Gln Leu Lys 
        195                 200                 205             


Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Phe Thr Gly Ser 
    210                 215                 220                 


Val Ser Leu Leu Ile Leu Val Leu Asp Ala Asn Asp Asn Ala Pro Ile 
225                 230                 235                 240 


Phe Asp Arg Pro Val Tyr Glu Val Lys Met Tyr Glu Asn Gln Val Asn 
                245                 250                 255     


Gln Thr Leu Val Ile Arg Leu Asn Ala Ser Asp Ser Asp Glu Gly Ile 
            260                 265                 270         


Asn Lys Glu Met Met Tyr Ser Phe Ser Ser Leu Val Pro Pro Thr Ile 
        275                 280                 285             


Arg Arg Lys Phe Trp Ile Asn Glu Arg Thr Gly Glu Ile Lys Val Asn 
    290                 295                 300                 


Asp Ala Ile Asp Phe Glu Asp Ser Asn Thr Tyr Glu Ile His Val Asp 
305                 310                 315                 320 


Val Thr Asp Lys Gly Asn Pro Pro Met Val Gly His Cys Thr Val Leu 
                325                 330                 335     


Val Glu Leu Leu Asp Glu Asn Asp Asn Ser Pro Glu Val Ile Val Thr 
            340                 345                 350         


Ser Leu Ser Leu Pro Val Lys Glu Asp Ala Gln Val Gly Thr Val Ile 
        355                 360                 365             


Ala Leu Ile Ser Val Ser Asp His Asp Ser Gly Ala Asn Gly Gln Val 
    370                 375                 380                 


Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr Tyr 
385                 390                 395                 400 


Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu Arg 
                405                 410                 415     


Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser Pro 
            420                 425                 430         


Pro Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Ala Phe Ala Gln Ser Glu Tyr Thr Val Phe Val Lys 
    450                 455                 460                 


Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp Asp 
465                 470                 475                 480 


Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu Arg 
                485                 490                 495     


Arg Leu Gly Glu Arg Ser Leu Ser Ser Tyr Val Ser Val His Ala Glu 
            500                 505                 510         


Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu Glu 
        515                 520                 525             


Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Gly Gly Val Pro Pro Leu 
    530                 535                 540                 


Gly Ser Asn Leu Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Leu Leu Ala Ser Pro Ala Gly Ser Ala Gly Gly Ala Val 
                565                 570                 575     


Ser Glu Leu Val Leu Arg Ser Val Val Ala Gly His Val Val Ala Lys 
            580                 585                 590         


Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Glu Leu Gln Ser Ala Ala Val Gly Ala Arg Ile Pro Phe Arg Val Gly 
    610                 615                 620                 


Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr Asp 
625                 630                 635                 640 


Ser Pro Arg Gln Arg Leu Leu Val Leu Val Lys Asp His Gly Glu Pro 
                645                 650                 655     


Ser Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Gly Ser 
            660                 665                 670         


Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Val Gly Val Ala Pro Glu 
        675                 680                 685             


Val Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile Cys Ala 
    690                 695                 700                 


Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala Leu Arg 
705                 710                 715                 720 


Cys Ser Ala Ala Pro Thr Glu Gly Ala Cys Gly Pro Val Lys Pro Thr 
                725                 730                 735     


Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln Gln Arg 
            740                 745                 750         


Arg Gln Arg Val Cys Ser Gly Glu Gly Leu Pro Lys Ala Asp Leu Met 
        755                 760                 765             


Ala Phe Ser Pro Ser Leu Pro Pro Cys Pro Met Val Asp Val Asp Gly 
    770                 775                 780                 


Glu Asp Gln Ser Ile Gly Gly Asp His Ser Arg Lys Val Gly Tyr Tyr 
785                 790                 795                 800 


Val Phe Ile Phe Leu Leu Cys Phe Met Asn Asn Ile Phe Ser Tyr Arg 
                805                 810                 815     


Ile Phe Ser Asn Met Tyr Gln Asn Ile Ser Phe Leu Ser Thr Phe His 
            820                 825                 830         


Leu Cys Leu Asn Ile Ser Ser Asp Thr Phe Val Ile 
        835                 840                 


<210>  5250
<211>  1007
<212>  PRT
<213>  Homo sapiens

<400>  5250

Met Glu Gln Ala Gly Thr Arg Pro Ala Ala Thr Glu His Pro Arg Leu 
1               5                   10                  15      


Arg Arg Pro Met Pro Trp Leu Leu Leu Leu Pro Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Pro Gly Pro Ala Ala Ser Gln Leu Arg Tyr Ser Val 
        35                  40                  45              


Pro Glu Glu Gln Ala Pro Gly Ala Leu Val Gly Asn Val Ala Arg Ala 
    50                  55                  60                  


Leu Gly Leu Glu Leu Arg Arg Leu Gly Pro Gly Cys Leu Arg Ile Asn 
65                  70                  75                  80  


His Leu Gly Ala Pro Ser Pro Arg Tyr Leu Glu Leu Asp Leu Thr Ser 
                85                  90                  95      


Gly Ala Leu Phe Val Asn Glu Arg Ile Asp Arg Glu Ala Leu Cys Glu 
            100                 105                 110         


Gln Arg Pro Arg Cys Leu Leu Ser Leu Glu Val Leu Ala His Asn Pro 
        115                 120                 125             


Val Ala Val Ser Ala Val Glu Val Glu Ile Leu Asp Ile Asn Asp Asn 
    130                 135                 140                 


Ser Pro Arg Phe Pro Arg Pro Asn Tyr Gln Leu Gln Val Ser Glu Ser 
145                 150                 155                 160 


Val Ala Pro Gly Ala Arg Phe His Ile Glu Ser Ala Gln Asp Pro Asp 
                165                 170                 175     


Val Gly Ala Asn Ser Val Gln Thr Tyr Glu Leu Ser Pro Ser Glu His 
            180                 185                 190         


Phe Glu Leu Asp Leu Lys Pro Leu Gln Glu Asn Ser Lys Val Leu Glu 
        195                 200                 205             


Leu Val Leu Arg Lys Gly Leu Asp Arg Glu Gln Ala Ala Leu His His 
    210                 215                 220                 


Leu Val Leu Thr Ala Val Asp Gly Gly Ile Pro Ala Arg Ser Gly Thr 
225                 230                 235                 240 


Ala Gln Ile Ser Val Arg Val Leu Asp Thr Asn Asp Asn Ser Pro Ala 
                245                 250                 255     


Phe Asp Gln Ser Thr Tyr Arg Val Gln Leu Arg Glu Asp Ser Pro Pro 
            260                 265                 270         


Gly Thr Leu Val Val Lys Leu Asn Ala Ser Asp Pro Asp Glu Gly Ser 
        275                 280                 285             


Asn Gly Glu Leu Arg Tyr Ser Leu Ser Ser Tyr Thr Ser Asp Arg Glu 
    290                 295                 300                 


Arg Gln Leu Phe Ser Ile Asp Ala Ser Thr Gly Glu Val Arg Val Ile 
305                 310                 315                 320 


Gly Gly Leu Asp Tyr Glu Glu Ala Ser Ser Tyr Gln Ile Tyr Val Gln 
                325                 330                 335     


Ala Thr Asp Arg Gly Pro Val Pro Met Ala Gly His Cys Lys Val Leu 
            340                 345                 350         


Val Asp Ile Val Asp Val Asn Asp Asn Ala Pro Glu Val Val Leu Thr 
        355                 360                 365             


Asp Leu Tyr Ser Pro Val Pro Glu Asn Ala Thr Pro Asn Thr Ile Val 
    370                 375                 380                 


Ala Val Leu Ser Val Asn Asp Gln Asp Ser Gly Pro Asn Arg Lys Val 
385                 390                 395                 400 


Ser Leu Gly Leu Glu Ala Thr Leu Pro Phe Arg Leu Asn Gly Phe Gly 
                405                 410                 415     


Asn Ser Tyr Thr Leu Val Val Ser Gly Pro Leu Asp Arg Glu Arg Val 
            420                 425                 430         


Ala Val Tyr Asn Ile Thr Val Thr Ala Thr Asp Gly Gly Ile Pro Gln 
        435                 440                 445             


Leu Thr Ser Leu Arg Thr Leu Lys Val Glu Ile Ser Asp Ile Asn Asp 
    450                 455                 460                 


Asn Pro Pro Ser Phe Leu Glu Asp Ser Tyr Ser Ile Tyr Ile Gln Glu 
465                 470                 475                 480 


Asn Asn Leu Pro Gly Val Leu Leu Cys Thr Val Gln Ala Thr Asp Pro 
                485                 490                 495     


Asp Glu Lys Glu Asn Ala Glu Val Thr Tyr Ser Leu Leu Glu Arg Glu 
            500                 505                 510         


Ile Gln Gly Leu Pro Val Thr Ser Tyr Val Ser Ile Asn Ser Ala Ser 
        515                 520                 525             


Gly Ser Leu Tyr Ala Val Asn Ser Phe Asp Tyr Glu Lys Phe Arg Glu 
    530                 535                 540                 


Phe Phe Val Thr Val Glu Ala Gln Asp Lys Gly Ser Pro Pro Leu Ser 
545                 550                 555                 560 


Ser Thr Val Thr Ala Asn Val Tyr Val Val Asp Met Asn Asp His Ala 
                565                 570                 575     


Pro His Ile Leu Tyr Pro Thr Ser Thr Asn Ser Ser Ala Ala Phe Glu 
            580                 585                 590         


Met Val Pro Arg Thr Ala Pro Ala Gly Tyr Leu Val Thr Lys Val Ile 
        595                 600                 605             


Ala Met Asp Ser Asp Ser Gly Gln Asn Ala Trp Leu Phe Tyr His Leu 
    610                 615                 620                 


Ala Gln Thr Ser Asp Leu Asp Leu Phe Lys Val Glu Leu His Thr Gly 
625                 630                 635                 640 


Glu Ile Arg Thr Thr Arg Lys Met Gly Asp Glu Ser Gly Ser Thr Phe 
                645                 650                 655     


Asn Leu Thr Val Val Val Arg Asp Asn Gly Glu Pro Ser Leu Ser Ala 
            660                 665                 670         


Ser Val Ala Ile Thr Val Ala Val Val Asp Arg Val Ser Lys Ile Leu 
        675                 680                 685             


Pro Asp Thr Gln Arg His Val Lys Ser Pro Arg Thr Tyr Ser Glu Ile 
    690                 695                 700                 


Thr Leu Tyr Leu Ile Ile Ala Leu Ser Thr Val Ser Phe Ile Phe Leu 
705                 710                 715                 720 


Leu Thr Ile Ile Ile Leu Ser Ile Ile Lys Cys Tyr Arg Tyr Thr Ala 
                725                 730                 735     


Tyr Gly Thr Ala Cys Cys Gly Gly Phe Cys Gly Val Arg Glu Arg Ser 
            740                 745                 750         


Pro Ala Glu Leu Tyr Lys Gln Ala Asn Asn Asn Ile Asp Ala Arg Ile 
        755                 760                 765             


Pro His Gly Leu Lys Val Gln Pro His Phe Ile Glu Val Arg Gly Asn 
    770                 775                 780                 


Gly Ser Leu Thr Lys Thr Tyr Cys Tyr Lys Ala Cys Leu Thr Ala Gly 
785                 790                 795                 800 


Ser Gly Ser Asp Thr Phe Met Phe Tyr Asn Thr Gly Ala Gln Thr Gly 
                805                 810                 815     


Pro Gly Pro Ser Gly Ala Gln Ala Ala Val Thr Asp Ser Arg Asn Leu 
            820                 825                 830         


Thr Gly Gln Ser Gly Gln Asn Ala Gly Asn Leu Ile Ile Leu Lys Asn 
        835                 840                 845             


Glu Ala Val Ser Gln Asn Glu Pro Arg Gln Pro Asn Pro Asp Trp Arg 
    850                 855                 860                 


Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser Val His Leu Glu 
865                 870                 875                 880 


Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro Asp Gln Gln Trp 
                885                 890                 895     


Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala Gly Glu Val Ser 
            900                 905                 910         


Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr 
        915                 920                 925             


Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys 
    930                 935                 940                 


Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro 
945                 950                 955                 960 


Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys 
                965                 970                 975     


Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln 
            980                 985                 990         


Glu Lys Lys Glu Lys Gly Asn Ser  Thr Thr Asp Asn Ser  Asp Gln 
        995                 1000                 1005         


<210>  5251
<211>  818
<212>  PRT
<213>  Homo sapiens

<400>  5251

Met Val Gly Cys Gly Val Ala Val Leu Cys Leu Trp Val Ser Cys Gly 
1               5                   10                  15      


Ala Ala Ala Gly Gln Leu Glu Tyr Ser Val Pro Glu Glu Thr Glu Arg 
            20                  25                  30          


Gly Val Ala Val Gly Asn Leu Ser Ala Asp Leu Arg Leu Pro Ala Ala 
        35                  40                  45              


Ala Met Ser Ser Arg Asn Phe Arg Phe Leu Ser Ser His Arg Glu Leu 
    50                  55                  60                  


Tyr Phe Gly Val Asp Leu Pro Ser Gly Asn Leu Val Val Arg Glu Pro 
65                  70                  75                  80  


Ala Asp Arg Glu Gln Leu Cys Arg Ala Lys Ala Ala Cys Val Leu Thr 
                85                  90                  95      


Tyr Asp Leu Val Leu Glu Asp Pro Leu Glu Leu His Lys Ile Arg Ile 
            100                 105                 110         


His Val Leu Asp Thr Asn Asp Asn Ser Pro Leu Phe Pro Ala Gly Asp 
        115                 120                 125             


Val Gln Leu His Ile Pro Glu Phe Leu Thr Pro Gly Ala Arg Phe Thr 
    130                 135                 140                 


Leu Pro Asn Ala Gln Asp Asp Asp Glu Gly Ser Asn Gly Ile Leu Ser 
145                 150                 155                 160 


Tyr Ser Leu Ser Pro Ser Gln His Phe Arg Leu Asp Met Gly Ser Arg 
                165                 170                 175     


Val Asp Gly Ser Glu Tyr Pro Glu Leu Val Leu Glu Lys Ala Leu Asp 
            180                 185                 190         


Arg Glu Gln Arg Ala Thr His Leu Leu Val Leu Thr Ala Arg Asp Gly 
        195                 200                 205             


Gly Leu Pro Ala Arg Ser Gly Asp Ala Gln Val Thr Ile Ile Val Val 
    210                 215                 220                 


Asp Thr Asn Asp Asn Ala Pro Val Phe Glu Arg Ser Val Tyr Arg Thr 
225                 230                 235                 240 


Lys Val Pro Glu Thr Ala Pro Asn Gly Thr Val Leu Phe Arg Val Gln 
                245                 250                 255     


Ala Leu Asp Pro Asp Glu Gly Ser Asn Gly Glu Val Gln Tyr Ser Leu 
            260                 265                 270         


Ser Asn Ser Thr Gln Ala Glu Leu Arg His Arg Phe His Val His Pro 
        275                 280                 285             


Lys Ser Gly Glu Val Gln Val Ala Ala Ser Leu Gly Pro Pro Glu Thr 
    290                 295                 300                 


Leu Leu Glu Ala Tyr Ile Glu Ala Arg Asp Glu Gly Val Phe Gly Leu 
305                 310                 315                 320 


Ala Ser Thr Ala Lys Leu Leu Val Glu Val Thr Asp Val Asn Asp His 
                325                 330                 335     


Ala Pro Glu Leu Asp Phe Leu Thr Leu Ser Asn Pro Val Pro Glu Asp 
            340                 345                 350         


Ala Ala Pro Gly Thr Val Ile Ala Leu Phe Ser Val Lys Asp Glu Asp 
        355                 360                 365             


Leu Asp Ser Asn Gly Arg Val Ile Cys Gly Met Ser Ser Ala Gly Pro 
    370                 375                 380                 


Phe Gln Leu Thr Ala Ser Phe Asp Asn Tyr Tyr Ser Leu Leu Ile Asp 
385                 390                 395                 400 


Gly Pro Leu Asp Arg Glu Gln Ile Ser Glu Tyr Gln Val Leu Ile Thr 
                405                 410                 415     


Ala Ser Asp Ser Gly Ser Pro Pro Leu Ser Thr Arg Arg Thr Ile Thr 
            420                 425                 430         


Val Ser Val Ala Asp Val Asn Asp Asn Thr Pro Asn Phe Pro Gln Pro 
        435                 440                 445             


Gln Gln Glu Leu Phe Val Ala Glu Asn Asn Gly Pro Gly Ala Ser Leu 
    450                 455                 460                 


Gly Arg Val Phe Ala Gln Asp Pro Asp Leu Gly Lys Asn Gly Leu Val 
465                 470                 475                 480 


Ser Tyr Glu Leu Leu Asp Val Ile Ser Glu Gly Pro Ser Ala Ser Ser 
                485                 490                 495     


Leu Leu Ala Val Glu Ser Ser Ser Gly Ala Ile Thr Ala Lys Thr Ser 
            500                 505                 510         


Phe Asp Phe Glu Gln Leu Arg Gly Phe His Phe Gln Val Glu Gly Arg 
        515                 520                 525             


Asp Gly Gly Ile Pro Pro Arg Ser Ala Thr Val Thr Ile Asn Leu Phe 
    530                 535                 540                 


Val Val Asp Arg Asn Asp Asn Tyr Pro Val Ile Leu Phe Pro Leu Pro 
545                 550                 555                 560 


Arg Asn Gly Ser Val Pro Val Glu Ile Val Pro Arg Ser Ala Arg Thr 
                565                 570                 575     


Gly His Leu Val Thr Lys Val Val Ala Glu Asp Ala Asp Ser Gly Ser 
            580                 585                 590         


Asn Ala Trp Leu Ser Tyr His Ile Ser Arg Ala Ser Asp Ser Ser Leu 
        595                 600                 605             


Phe Arg Ile Ser Ala Asn Ile Gly Glu Leu Arg Thr Ala Arg Leu Val 
    610                 615                 620                 


Leu Pro Thr Asp Ala Val Lys Gln Arg Val Val Val Val Val Arg Asp 
625                 630                 635                 640 


His Gly Asp Pro Pro Leu Ser Ser Ser Val Thr Leu Gly Val Leu Leu 
                645                 650                 655     


Ser Asn Ser Val Pro Gln Leu Leu Pro Asp Phe Glu Asp Val Trp Glu 
            660                 665                 670         


Pro Gly Gly Gln Leu Ser Ala Gln Asn Leu Tyr Leu Val Ile Ala Leu 
        675                 680                 685             


Ala Cys Ile Ser Phe Leu Phe Leu Gly Cys Leu Leu Phe Phe Val Cys 
    690                 695                 700                 


Thr Lys Leu His Gln Ser Pro Gly Cys Cys Ala Gln Ser Cys Cys Arg 
705                 710                 715                 720 


Ser Thr Glu Asp Leu Arg Tyr Gly Ser Lys Met Val Ser Asn Pro Cys 
                725                 730                 735     


Met Thr Ser Ala Thr Ile Asp Val Thr Thr Val Glu Arg Leu Ser Gln 
            740                 745                 750         


Thr Tyr Leu Tyr Arg Ala Ser Leu Gly Leu Gly Ser Asp Asn Asn Ser 
        755                 760                 765             


Leu Leu Leu Arg Gly Glu Tyr Asn Ala Ala Asp Leu Arg Asn Leu Ala 
    770                 775                 780                 


Thr Gly Val Gly Leu Asn Leu Pro Ile Ser Cys Ile Gln Ile Arg Asn 
785                 790                 795                 800 


Arg Lys Gly Asp His Ala Asn Val Asn Ala Met Val Ser Lys Phe Tyr 
                805                 810                 815     


Gly Ile 
        


<210>  5252
<211>  694
<212>  PRT
<213>  Homo sapiens

<400>  5252

Met Glu Trp Gly Tyr Leu Leu Glu Val Thr Ser Leu Leu Ala Ala Leu 
1               5                   10                  15      


Ala Leu Leu Gln Arg Ser Ser Gly Ala Ala Ala Ala Ser Ala Lys Glu 
            20                  25                  30          


Leu Ala Cys Gln Glu Ile Thr Val Pro Leu Cys Lys Gly Ile Gly Tyr 
        35                  40                  45              


Asn Tyr Thr Tyr Met Pro Asn Gln Phe Asn His Asp Thr Gln Asp Glu 
    50                  55                  60                  


Ala Gly Leu Glu Val His Gln Phe Trp Pro Leu Val Glu Ile Gln Cys 
65                  70                  75                  80  


Ser Pro Asp Leu Lys Phe Phe Leu Cys Ser Met Tyr Thr Pro Ile Cys 
                85                  90                  95      


Leu Glu Asp Tyr Lys Lys Pro Leu Pro Pro Cys Arg Ser Val Cys Glu 
            100                 105                 110         


Arg Ala Lys Ala Gly Cys Ala Pro Leu Met Arg Gln Tyr Gly Phe Ala 
        115                 120                 125             


Trp Pro Asp Arg Met Arg Cys Asp Arg Leu Pro Glu Gln Gly Asn Pro 
    130                 135                 140                 


Asp Thr Leu Cys Met Asp Tyr Asn Arg Thr Asp Leu Thr Thr Ala Ala 
145                 150                 155                 160 


Pro Ser Pro Pro Arg Arg Leu Pro Pro Pro Pro Pro Gly Glu Gln Pro 
                165                 170                 175     


Pro Ser Gly Ser Gly His Gly Arg Pro Pro Gly Ala Arg Pro Pro His 
            180                 185                 190         


Arg Gly Gly Gly Arg Gly Gly Gly Gly Gly Asp Ala Ala Ala Pro Pro 
        195                 200                 205             


Ala Arg Gly Gly Gly Gly Gly Gly Lys Ala Arg Pro Pro Gly Gly Gly 
    210                 215                 220                 


Ala Ala Pro Cys Glu Pro Gly Cys Gln Cys Arg Ala Pro Met Val Ser 
225                 230                 235                 240 


Val Ser Ser Glu Arg His Pro Leu Tyr Asn Arg Val Lys Thr Gly Gln 
                245                 250                 255     


Ile Ala Asn Cys Ala Leu Pro Cys His Asn Pro Phe Phe Ser Gln Asp 
            260                 265                 270         


Glu Arg Ala Phe Thr Val Phe Trp Ile Gly Leu Trp Ser Val Leu Cys 
        275                 280                 285             


Phe Val Ser Thr Phe Ala Thr Val Ser Thr Phe Leu Ile Asp Met Glu 
    290                 295                 300                 


Arg Phe Lys Tyr Pro Glu Arg Pro Ile Ile Phe Leu Ser Ala Cys Tyr 
305                 310                 315                 320 


Leu Phe Val Ser Val Gly Tyr Leu Val Arg Leu Val Ala Gly His Glu 
                325                 330                 335     


Lys Val Ala Cys Ser Gly Gly Ala Pro Gly Ala Gly Gly Ala Gly Gly 
            340                 345                 350         


Ala Gly Gly Ala Ala Ala Gly Ala Gly Ala Ala Gly Ala Gly Ala Gly 
        355                 360                 365             


Gly Pro Gly Gly Arg Gly Glu Tyr Glu Glu Leu Gly Ala Val Glu Gln 
    370                 375                 380                 


His Val Arg Tyr Glu Thr Thr Gly Pro Ala Leu Cys Thr Val Val Phe 
385                 390                 395                 400 


Leu Leu Val Tyr Phe Phe Gly Met Ala Ser Ser Ile Trp Trp Val Ile 
                405                 410                 415     


Leu Ser Leu Thr Trp Phe Leu Ala Ala Gly Met Lys Trp Gly Asn Glu 
            420                 425                 430         


Ala Ile Ala Gly Tyr Ser Gln Tyr Phe His Leu Ala Ala Trp Leu Val 
        435                 440                 445             


Pro Ser Val Lys Ser Ile Ala Val Leu Ala Leu Ser Ser Val Asp Gly 
    450                 455                 460                 


Asp Pro Val Ala Gly Ile Cys Tyr Val Gly Asn Gln Ser Leu Asp Asn 
465                 470                 475                 480 


Leu Arg Gly Phe Val Leu Ala Pro Leu Val Ile Tyr Leu Phe Ile Gly 
                485                 490                 495     


Thr Met Phe Leu Leu Ala Gly Phe Val Ser Leu Phe Arg Ile Arg Ser 
            500                 505                 510         


Val Ile Lys Gln Gln Asp Gly Pro Thr Lys Thr His Lys Leu Glu Lys 
        515                 520                 525             


Leu Met Ile Arg Leu Gly Leu Phe Thr Val Leu Tyr Thr Val Pro Ala 
    530                 535                 540                 


Ala Val Val Val Ala Cys Leu Phe Tyr Glu Gln His Asn Arg Pro Arg 
545                 550                 555                 560 


Trp Glu Ala Thr His Asn Cys Pro Cys Leu Arg Asp Leu Gln Pro Asp 
                565                 570                 575     


Gln Ala Arg Arg Pro Asp Tyr Ala Val Phe Met Leu Lys Tyr Phe Met 
            580                 585                 590         


Cys Leu Val Val Gly Ile Thr Ser Gly Val Trp Val Trp Ser Gly Lys 
        595                 600                 605             


Thr Leu Glu Ser Trp Arg Ser Leu Cys Thr Arg Cys Cys Trp Ala Ser 
    610                 615                 620                 


Lys Gly Ala Ala Val Gly Gly Gly Ala Gly Ala Thr Ala Ala Gly Gly 
625                 630                 635                 640 


Gly Gly Gly Pro Gly Gly Gly Gly Gly Gly Gly Pro Gly Gly Gly Gly 
                645                 650                 655     


Gly Pro Gly Gly Gly Gly Gly Ser Leu Tyr Ser Asp Val Ser Thr Gly 
            660                 665                 670         


Leu Thr Trp Arg Ser Gly Thr Ala Ser Ser Val Ser Tyr Pro Lys Gln 
        675                 680                 685             


Met Pro Leu Ser Gln Val 
    690                 


<210>  5253
<211>  948
<212>  PRT
<213>  Homo sapiens

<400>  5253

Met Val Ser Arg Cys Ser Cys Leu Gly Val Gln Cys Leu Leu Leu Ser 
1               5                   10                  15      


Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His Tyr 
            20                  25                  30          


Ser Val Tyr Glu Glu Ala Arg His Gly Thr Phe Val Gly Arg Ile Ala 
        35                  40                  45              


Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Gln Arg Leu Phe Arg 
    50                  55                  60                  


Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln Asn 
65                  70                  75                  80  


Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys Gly 
                85                  90                  95      


Arg Ser Val Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg Pro 
            100                 105                 110         


Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp Asn 
        115                 120                 125             


Pro Pro Arg Phe Ser Val Thr Glu Gln Lys Leu Ser Ile Pro Glu Ser 
    130                 135                 140                 


Arg Leu Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala Asp 
145                 150                 155                 160 


Val Gly Glu Asn Ala Leu Leu Thr Tyr Lys Leu Ser Pro Asn Glu Tyr 
                165                 170                 175     


Phe Val Leu Asp Ile Ile Asn Lys Lys Asp Lys Asp Lys Phe Pro Val 
            180                 185                 190         


Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Glu Asn Pro Gln Leu Lys 
        195                 200                 205             


Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Phe Thr Gly Ser 
    210                 215                 220                 


Val Ser Leu Leu Ile Leu Val Leu Asp Ala Asn Asp Asn Ala Pro Ile 
225                 230                 235                 240 


Phe Asp Arg Pro Val Tyr Glu Val Lys Met Tyr Glu Asn Gln Val Asn 
                245                 250                 255     


Gln Thr Leu Val Ile Arg Leu Asn Ala Ser Asp Ser Asp Glu Gly Ile 
            260                 265                 270         


Asn Lys Glu Met Met Tyr Ser Phe Ser Ser Leu Val Pro Pro Thr Ile 
        275                 280                 285             


Arg Arg Lys Phe Trp Ile Asn Glu Arg Thr Gly Glu Ile Lys Val Asn 
    290                 295                 300                 


Asp Ala Ile Asp Phe Glu Asp Ser Asn Thr Tyr Glu Ile His Val Asp 
305                 310                 315                 320 


Val Thr Asp Lys Gly Asn Pro Pro Met Val Gly His Cys Thr Val Leu 
                325                 330                 335     


Val Glu Leu Leu Asp Glu Asn Asp Asn Ser Pro Glu Val Ile Val Thr 
            340                 345                 350         


Ser Leu Ser Leu Pro Val Lys Glu Asp Ala Gln Val Gly Thr Val Ile 
        355                 360                 365             


Ala Leu Ile Ser Val Ser Asp His Asp Ser Gly Ala Asn Gly Gln Val 
    370                 375                 380                 


Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr Tyr 
385                 390                 395                 400 


Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu Arg 
                405                 410                 415     


Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser Pro 
            420                 425                 430         


Pro Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Ala Phe Ala Gln Ser Glu Tyr Thr Val Phe Val Lys 
    450                 455                 460                 


Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp Asp 
465                 470                 475                 480 


Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu Arg 
                485                 490                 495     


Arg Leu Gly Glu Arg Ser Leu Ser Ser Tyr Val Ser Val His Ala Glu 
            500                 505                 510         


Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu Glu 
        515                 520                 525             


Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Gly Gly Val Pro Pro Leu 
    530                 535                 540                 


Gly Ser Asn Leu Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Leu Leu Ala Ser Pro Ala Gly Ser Ala Gly Gly Ala Val 
                565                 570                 575     


Ser Glu Leu Val Leu Arg Ser Val Val Ala Gly His Val Val Ala Lys 
            580                 585                 590         


Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Glu Leu Gln Ser Ala Ala Val Gly Ala Arg Ile Pro Phe Arg Val Gly 
    610                 615                 620                 


Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr Asp 
625                 630                 635                 640 


Ser Pro Arg Gln Arg Leu Leu Val Leu Val Lys Asp His Gly Glu Pro 
                645                 650                 655     


Ser Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Gly Ser 
            660                 665                 670         


Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Val Gly Val Ala Pro Glu 
        675                 680                 685             


Val Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile Cys Ala 
    690                 695                 700                 


Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala Leu Arg 
705                 710                 715                 720 


Cys Ser Ala Ala Pro Thr Glu Gly Ala Cys Gly Pro Val Lys Pro Thr 
                725                 730                 735     


Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln Gln Arg 
            740                 745                 750         


Arg Gln Arg Val Cys Ser Gly Glu Gly Leu Pro Lys Ala Asp Leu Met 
        755                 760                 765             


Ala Phe Ser Pro Ser Leu Pro Pro Cys Pro Met Val Asp Val Asp Gly 
    770                 775                 780                 


Glu Asp Gln Ser Ile Gly Gly Asp His Ser Arg Lys Pro Arg Gln Pro 
785                 790                 795                 800 


Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser 
                805                 810                 815     


Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly 
            820                 825                 830         


Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu 
        835                 840                 845             


Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser 
    850                 855                 860                 


Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly 
865                 870                 875                 880 


Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser 
                885                 890                 895     


Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile 
            900                 905                 910         


Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp 
    930                 935                 940                 


Asn Ser Asp Gln 
945             


<210>  5254
<211>  818
<212>  PRT
<213>  Homo sapiens

<400>  5254

Met Val Gly Cys Gly Val Ala Val Leu Cys Leu Trp Val Ser Cys Gly 
1               5                   10                  15      


Ala Ala Ala Gly Gln Leu Glu Tyr Ser Val Pro Glu Glu Thr Glu Arg 
            20                  25                  30          


Gly Val Ala Val Gly Asn Leu Ser Ala Asp Leu Arg Leu Pro Ala Ala 
        35                  40                  45              


Ala Met Ser Ser Arg Asn Phe Arg Phe Leu Ser Ser His Arg Glu Leu 
    50                  55                  60                  


Tyr Phe Gly Val Asp Leu Pro Ser Gly Asn Leu Val Val Arg Glu Pro 
65                  70                  75                  80  


Ala Asp Arg Glu Gln Leu Cys Arg Ala Lys Ala Ala Cys Val Leu Thr 
                85                  90                  95      


Tyr Asp Leu Val Leu Glu Asp Pro Leu Glu Leu His Lys Ile Arg Ile 
            100                 105                 110         


His Val Leu Asp Thr Asn Asp Asn Ser Pro Leu Phe Pro Ala Gly Asp 
        115                 120                 125             


Val Gln Leu His Ile Pro Glu Phe Leu Thr Pro Gly Ala Arg Phe Thr 
    130                 135                 140                 


Leu Pro Asn Ala Gln Asp Asp Asp Glu Gly Ser Asn Gly Ile Leu Ser 
145                 150                 155                 160 


Tyr Ser Leu Ser Pro Ser Gln His Phe Arg Leu Asp Met Gly Ser Arg 
                165                 170                 175     


Val Asp Gly Ser Glu Tyr Pro Glu Leu Val Leu Glu Lys Ala Leu Asp 
            180                 185                 190         


Arg Glu Gln Arg Ala Thr His Leu Leu Val Leu Thr Ala Arg Asp Gly 
        195                 200                 205             


Gly Leu Pro Ala Arg Ser Gly Asp Ala Gln Val Thr Ile Ile Val Val 
    210                 215                 220                 


Asp Thr Asn Asp Asn Ala Pro Val Phe Glu Arg Ser Val Tyr Arg Thr 
225                 230                 235                 240 


Lys Val Pro Glu Thr Ala Pro Asn Gly Thr Val Leu Phe Arg Val Gln 
                245                 250                 255     


Ala Leu Asp Pro Asp Glu Gly Ser Asn Gly Glu Val Gln Tyr Ser Leu 
            260                 265                 270         


Ser Asn Ser Thr Gln Ala Glu Leu Arg His Arg Phe His Val His Pro 
        275                 280                 285             


Lys Ser Gly Glu Val Gln Val Ala Ala Ser Leu Gly Pro Pro Glu Thr 
    290                 295                 300                 


Leu Leu Glu Ala Tyr Ile Glu Ala Arg Asp Glu Gly Val Phe Gly Leu 
305                 310                 315                 320 


Ala Ser Thr Ala Lys Leu Leu Val Glu Val Thr Asp Val Asn Asp His 
                325                 330                 335     


Ala Pro Glu Leu Asp Phe Leu Thr Leu Ser Asn Pro Val Pro Glu Asp 
            340                 345                 350         


Ala Ala Pro Gly Thr Val Ile Ala Leu Phe Ser Val Lys Asp Glu Asp 
        355                 360                 365             


Leu Asp Ser Asn Gly Arg Val Ile Cys Gly Met Ser Ser Ala Gly Pro 
    370                 375                 380                 


Phe Gln Leu Thr Ala Ser Phe Asp Asn Tyr Tyr Ser Leu Leu Ile Asp 
385                 390                 395                 400 


Gly Pro Leu Asp Arg Glu Gln Ile Ser Glu Tyr Gln Val Leu Ile Thr 
                405                 410                 415     


Ala Ser Asp Ser Gly Ser Pro Pro Leu Ser Thr Arg Arg Thr Ile Thr 
            420                 425                 430         


Val Ser Val Ala Asp Val Asn Asp Asn Thr Pro Asn Phe Pro Gln Pro 
        435                 440                 445             


Gln Gln Glu Leu Phe Val Ala Glu Asn Asn Gly Pro Gly Ala Ser Leu 
    450                 455                 460                 


Gly Arg Val Phe Ala Gln Asp Pro Asp Leu Gly Lys Asn Gly Leu Val 
465                 470                 475                 480 


Ser Tyr Glu Leu Leu Asp Val Ile Ser Glu Gly Pro Ser Ala Ser Ser 
                485                 490                 495     


Leu Leu Ala Val Glu Ser Ser Ser Gly Ala Ile Thr Ala Lys Thr Ser 
            500                 505                 510         


Phe Asp Phe Glu Gln Leu Arg Gly Phe His Phe Gln Val Glu Gly Arg 
        515                 520                 525             


Asp Gly Gly Ile Pro Pro Arg Ser Ala Thr Val Thr Ile Asn Leu Phe 
    530                 535                 540                 


Val Val Asp Arg Asn Asp Asn Tyr Pro Val Ile Leu Phe Pro Leu Pro 
545                 550                 555                 560 


Arg Asn Gly Ser Val Pro Val Glu Ile Val Pro Arg Ser Ala Arg Thr 
                565                 570                 575     


Gly His Leu Val Thr Lys Val Val Ala Glu Asp Ala Asp Ser Gly Ser 
            580                 585                 590         


Asn Ala Trp Leu Ser Tyr His Ile Ser Arg Ala Ser Asp Ser Ser Leu 
        595                 600                 605             


Phe Arg Ile Ser Ala Asn Ile Gly Glu Leu Arg Thr Ala Arg Leu Val 
    610                 615                 620                 


Leu Pro Thr Asp Ala Val Lys Gln Arg Val Val Val Val Val Arg Asp 
625                 630                 635                 640 


His Gly Asp Pro Pro Leu Ser Ser Ser Val Thr Leu Gly Val Leu Leu 
                645                 650                 655     


Ser Asn Ser Val Pro Gln Leu Leu Pro Asp Phe Glu Asp Val Trp Glu 
            660                 665                 670         


Pro Gly Gly Gln Leu Ser Ala Gln Asn Leu Tyr Leu Val Ile Ala Leu 
        675                 680                 685             


Ala Cys Ile Ser Phe Leu Phe Leu Gly Cys Leu Leu Phe Phe Val Cys 
    690                 695                 700                 


Thr Lys Leu His Gln Ser Pro Gly Cys Cys Ala Gln Ser Cys Cys Arg 
705                 710                 715                 720 


Ser Thr Glu Asp Leu Arg Tyr Gly Ser Lys Met Val Ser Asn Pro Cys 
                725                 730                 735     


Met Thr Ser Ala Thr Ile Asp Val Thr Thr Val Glu Arg Leu Ser Gln 
            740                 745                 750         


Thr Tyr Leu Tyr Arg Ala Ser Leu Gly Leu Gly Ser Asp Asn Asn Ser 
        755                 760                 765             


Leu Leu Leu Arg Gly Glu Tyr Asn Ala Ala Asp Leu Arg Asn Leu Ala 
    770                 775                 780                 


Thr Gly Val Gly Leu Asn Leu Pro Ile Ser Cys Ile Gln Ile Arg Asn 
785                 790                 795                 800 


Arg Lys Gly Asp His Ala Asn Val Asn Ala Met Val Ser Lys Phe Tyr 
                805                 810                 815     


Gly Ile 
        


<210>  5255
<211>  963
<212>  PRT
<213>  Homo sapiens

<400>  5255

Met Val Gly Cys Gly Val Ala Val Leu Cys Leu Trp Val Ser Cys Gly 
1               5                   10                  15      


Ala Ala Ala Gly Gln Leu Glu Tyr Ser Val Pro Glu Glu Thr Glu Arg 
            20                  25                  30          


Gly Val Ala Val Gly Asn Leu Ser Ala Asp Leu Arg Leu Pro Ala Ala 
        35                  40                  45              


Ala Met Ser Ser Arg Asn Phe Arg Phe Leu Ser Ser His Arg Glu Leu 
    50                  55                  60                  


Tyr Phe Gly Val Asp Leu Pro Ser Gly Asn Leu Val Val Arg Glu Pro 
65                  70                  75                  80  


Ala Asp Arg Glu Gln Leu Cys Arg Ala Lys Ala Ala Cys Val Leu Thr 
                85                  90                  95      


Tyr Asp Leu Val Leu Glu Asp Pro Leu Glu Leu His Lys Ile Arg Ile 
            100                 105                 110         


His Val Leu Asp Thr Asn Asp Asn Ser Pro Leu Phe Pro Ala Gly Asp 
        115                 120                 125             


Val Gln Leu His Ile Pro Glu Phe Leu Thr Pro Gly Ala Arg Phe Thr 
    130                 135                 140                 


Leu Pro Asn Ala Gln Asp Asp Asp Glu Gly Ser Asn Gly Ile Leu Ser 
145                 150                 155                 160 


Tyr Ser Leu Ser Pro Ser Gln His Phe Arg Leu Asp Met Gly Ser Arg 
                165                 170                 175     


Val Asp Gly Ser Glu Tyr Pro Glu Leu Val Leu Glu Lys Ala Leu Asp 
            180                 185                 190         


Arg Glu Gln Arg Ala Thr His Leu Leu Val Leu Thr Ala Arg Asp Gly 
        195                 200                 205             


Gly Leu Pro Ala Arg Ser Gly Asp Ala Gln Val Thr Ile Ile Val Val 
    210                 215                 220                 


Asp Thr Asn Asp Asn Ala Pro Val Phe Glu Arg Ser Val Tyr Arg Thr 
225                 230                 235                 240 


Lys Val Pro Glu Thr Ala Pro Asn Gly Thr Val Leu Phe Arg Val Gln 
                245                 250                 255     


Ala Leu Asp Pro Asp Glu Gly Ser Asn Gly Glu Val Gln Tyr Ser Leu 
            260                 265                 270         


Ser Asn Ser Thr Gln Ala Glu Leu Arg His Arg Phe His Val His Pro 
        275                 280                 285             


Lys Ser Gly Glu Val Gln Val Ala Ala Ser Leu Gly Pro Pro Glu Thr 
    290                 295                 300                 


Leu Leu Glu Ala Tyr Ile Glu Ala Arg Asp Glu Gly Val Phe Gly Leu 
305                 310                 315                 320 


Ala Ser Thr Ala Lys Leu Leu Val Glu Val Thr Asp Val Asn Asp His 
                325                 330                 335     


Ala Pro Glu Leu Asp Phe Leu Thr Leu Ser Asn Pro Val Pro Glu Asp 
            340                 345                 350         


Ala Ala Pro Gly Thr Val Ile Ala Leu Phe Ser Val Lys Asp Glu Asp 
        355                 360                 365             


Leu Asp Ser Asn Gly Arg Val Ile Cys Gly Met Ser Ser Ala Gly Pro 
    370                 375                 380                 


Phe Gln Leu Thr Ala Ser Phe Asp Asn Tyr Tyr Ser Leu Leu Ile Asp 
385                 390                 395                 400 


Gly Pro Leu Asp Arg Glu Gln Ile Ser Glu Tyr Gln Val Leu Ile Thr 
                405                 410                 415     


Ala Ser Asp Ser Gly Ser Pro Pro Leu Ser Thr Arg Arg Thr Ile Thr 
            420                 425                 430         


Val Ser Val Ala Asp Val Asn Asp Asn Thr Pro Asn Phe Pro Gln Pro 
        435                 440                 445             


Gln Gln Glu Leu Phe Val Ala Glu Asn Asn Gly Pro Gly Ala Ser Leu 
    450                 455                 460                 


Gly Arg Val Phe Ala Gln Asp Pro Asp Leu Gly Lys Asn Gly Leu Val 
465                 470                 475                 480 


Ser Tyr Glu Leu Leu Asp Val Ile Ser Glu Gly Pro Ser Ala Ser Ser 
                485                 490                 495     


Leu Leu Ala Val Glu Ser Ser Ser Gly Ala Ile Thr Ala Lys Thr Ser 
            500                 505                 510         


Phe Asp Phe Glu Gln Leu Arg Gly Phe His Phe Gln Val Glu Gly Arg 
        515                 520                 525             


Asp Gly Gly Ile Pro Pro Arg Ser Ala Thr Val Thr Ile Asn Leu Phe 
    530                 535                 540                 


Val Val Asp Arg Asn Asp Asn Tyr Pro Val Ile Leu Phe Pro Leu Pro 
545                 550                 555                 560 


Arg Asn Gly Ser Val Pro Val Glu Ile Val Pro Arg Ser Ala Arg Thr 
                565                 570                 575     


Gly His Leu Val Thr Lys Val Val Ala Glu Asp Ala Asp Ser Gly Ser 
            580                 585                 590         


Asn Ala Trp Leu Ser Tyr His Ile Ser Arg Ala Ser Asp Ser Ser Leu 
        595                 600                 605             


Phe Arg Ile Ser Ala Asn Ile Gly Glu Leu Arg Thr Ala Arg Leu Val 
    610                 615                 620                 


Leu Pro Thr Asp Ala Val Lys Gln Arg Val Val Val Val Val Arg Asp 
625                 630                 635                 640 


His Gly Asp Pro Pro Leu Ser Ser Ser Val Thr Leu Gly Val Leu Leu 
                645                 650                 655     


Ser Asn Ser Val Pro Gln Leu Leu Pro Asp Phe Glu Asp Val Trp Glu 
            660                 665                 670         


Pro Gly Gly Gln Leu Ser Ala Gln Asn Leu Tyr Leu Val Ile Ala Leu 
        675                 680                 685             


Ala Cys Ile Ser Phe Leu Phe Leu Gly Cys Leu Leu Phe Phe Val Cys 
    690                 695                 700                 


Thr Lys Leu His Gln Ser Pro Gly Cys Cys Ala Gln Ser Cys Cys Arg 
705                 710                 715                 720 


Ser Thr Glu Asp Leu Arg Tyr Gly Ser Lys Met Val Ser Asn Pro Cys 
                725                 730                 735     


Met Thr Ser Ala Thr Ile Asp Val Thr Thr Val Glu Arg Leu Ser Gln 
            740                 745                 750         


Thr Tyr Leu Tyr Arg Ala Ser Leu Gly Leu Gly Ser Asp Asn Asn Ser 
        755                 760                 765             


Leu Leu Leu Arg Gly Glu Tyr Asn Ala Ala Asp Leu Arg Asn Leu Ala 
    770                 775                 780                 


Thr Gly Val Gly Leu Asn Leu Pro Ile Ser Cys Ile Gln Ile Arg Asn 
785                 790                 795                 800 


Arg Lys Gly Asp His Ala Asn Val Asn Ala Met Pro Arg Gln Pro Asn 
                805                 810                 815     


Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser 
            820                 825                 830         


Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro 
        835                 840                 845             


Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala 
    850                 855                 860                 


Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp 
865                 870                 875                 880 


Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu 
                885                 890                 895     


Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile 
            900                 905                 910         


Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr 
        915                 920                 925             


Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly 
    930                 935                 940                 


Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn 
945                 950                 955                 960 


Ser Asp Gln 
            


<210>  5256
<211>  884
<212>  PRT
<213>  Homo sapiens

<400>  5256

Met Glu Gln Ala Gly Thr Arg Pro Ala Ala Thr Glu His Pro Arg Leu 
1               5                   10                  15      


Arg Arg Pro Met Pro Trp Leu Leu Leu Leu Pro Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Pro Gly Pro Ala Ala Ser Gln Leu Arg Tyr Ser Val 
        35                  40                  45              


Pro Glu Glu Gln Ala Pro Gly Ala Leu Val Gly Asn Val Ala Arg Ala 
    50                  55                  60                  


Leu Gly Leu Glu Leu Arg Arg Leu Gly Pro Gly Cys Leu Arg Ile Asn 
65                  70                  75                  80  


His Leu Gly Ala Pro Ser Pro Arg Tyr Leu Glu Leu Asp Leu Thr Ser 
                85                  90                  95      


Gly Ala Leu Phe Val Asn Glu Arg Ile Asp Arg Glu Ala Leu Cys Glu 
            100                 105                 110         


Gln Arg Pro Arg Cys Leu Leu Ser Leu Glu Val Leu Ala His Asn Pro 
        115                 120                 125             


Val Ala Val Ser Ala Val Glu Val Glu Ile Leu Asp Ile Asn Asp Asn 
    130                 135                 140                 


Ser Pro Arg Phe Pro Arg Pro Asn Tyr Gln Leu Gln Val Ser Glu Ser 
145                 150                 155                 160 


Val Ala Pro Gly Ala Arg Phe His Ile Glu Ser Ala Gln Asp Pro Asp 
                165                 170                 175     


Val Gly Ala Asn Ser Val Gln Thr Tyr Glu Leu Ser Pro Ser Glu His 
            180                 185                 190         


Phe Glu Leu Asp Leu Lys Pro Leu Gln Glu Asn Ser Lys Val Leu Glu 
        195                 200                 205             


Leu Val Leu Arg Lys Gly Leu Asp Arg Glu Gln Ala Ala Leu His His 
    210                 215                 220                 


Leu Val Leu Thr Ala Val Asp Gly Gly Ile Pro Ala Arg Ser Gly Thr 
225                 230                 235                 240 


Ala Gln Ile Ser Val Arg Val Leu Asp Thr Asn Asp Asn Ser Pro Ala 
                245                 250                 255     


Phe Asp Gln Ser Thr Tyr Arg Val Gln Leu Arg Glu Asp Ser Pro Pro 
            260                 265                 270         


Gly Thr Leu Val Val Lys Leu Asn Ala Ser Asp Pro Asp Glu Gly Ser 
        275                 280                 285             


Asn Gly Glu Leu Arg Tyr Ser Leu Ser Ser Tyr Thr Ser Asp Arg Glu 
    290                 295                 300                 


Arg Gln Leu Phe Ser Ile Asp Ala Ser Thr Gly Glu Val Arg Val Ile 
305                 310                 315                 320 


Gly Gly Leu Asp Tyr Glu Glu Ala Ser Ser Tyr Gln Ile Tyr Val Gln 
                325                 330                 335     


Ala Thr Asp Arg Gly Pro Val Pro Met Ala Gly His Cys Lys Val Leu 
            340                 345                 350         


Val Asp Ile Val Asp Val Asn Asp Asn Ala Pro Glu Val Val Leu Thr 
        355                 360                 365             


Asp Leu Tyr Ser Pro Val Pro Glu Asn Ala Thr Pro Asn Thr Ile Val 
    370                 375                 380                 


Ala Val Leu Ser Val Asn Asp Gln Asp Ser Gly Pro Asn Arg Lys Val 
385                 390                 395                 400 


Ser Leu Gly Leu Glu Ala Thr Leu Pro Phe Arg Leu Asn Gly Phe Gly 
                405                 410                 415     


Asn Ser Tyr Thr Leu Val Val Ser Gly Pro Leu Asp Arg Glu Arg Val 
            420                 425                 430         


Ala Val Tyr Asn Ile Thr Val Thr Ala Thr Asp Gly Gly Ile Pro Gln 
        435                 440                 445             


Leu Thr Ser Leu Arg Thr Leu Lys Val Glu Ile Ser Asp Ile Asn Asp 
    450                 455                 460                 


Asn Pro Pro Ser Phe Leu Glu Asp Ser Tyr Ser Ile Tyr Ile Gln Glu 
465                 470                 475                 480 


Asn Asn Leu Pro Gly Val Leu Leu Cys Thr Val Gln Ala Thr Asp Pro 
                485                 490                 495     


Asp Glu Lys Glu Asn Ala Glu Val Thr Tyr Ser Leu Leu Glu Arg Glu 
            500                 505                 510         


Ile Gln Gly Leu Pro Val Thr Ser Tyr Val Ser Ile Asn Ser Ala Ser 
        515                 520                 525             


Gly Ser Leu Tyr Ala Val Asn Ser Phe Asp Tyr Glu Lys Phe Arg Glu 
    530                 535                 540                 


Phe Phe Val Thr Val Glu Ala Gln Asp Lys Gly Ser Pro Pro Leu Ser 
545                 550                 555                 560 


Ser Thr Val Thr Ala Asn Val Tyr Val Val Asp Met Asn Asp His Ala 
                565                 570                 575     


Pro His Ile Leu Tyr Pro Thr Ser Thr Asn Ser Ser Ala Ala Phe Glu 
            580                 585                 590         


Met Val Pro Arg Thr Ala Pro Ala Gly Tyr Leu Val Thr Lys Val Ile 
        595                 600                 605             


Ala Met Asp Ser Asp Ser Gly Gln Asn Ala Trp Leu Phe Tyr His Leu 
    610                 615                 620                 


Ala Gln Thr Ser Asp Leu Asp Leu Phe Lys Val Glu Leu His Thr Gly 
625                 630                 635                 640 


Glu Ile Arg Thr Thr Arg Lys Met Gly Asp Glu Ser Gly Ser Thr Phe 
                645                 650                 655     


Asn Leu Thr Val Val Val Arg Asp Asn Gly Glu Pro Ser Leu Ser Ala 
            660                 665                 670         


Ser Val Ala Ile Thr Val Ala Val Val Asp Arg Val Ser Lys Ile Leu 
        675                 680                 685             


Pro Asp Thr Gln Arg His Val Lys Ser Pro Arg Thr Tyr Ser Glu Ile 
    690                 695                 700                 


Thr Leu Tyr Leu Ile Ile Ala Leu Ser Thr Val Ser Phe Ile Phe Leu 
705                 710                 715                 720 


Leu Thr Ile Ile Ile Leu Ser Ile Ile Lys Cys Tyr Arg Tyr Thr Ala 
                725                 730                 735     


Tyr Gly Thr Ala Cys Cys Gly Gly Phe Cys Gly Val Arg Glu Arg Ser 
            740                 745                 750         


Pro Ala Glu Leu Tyr Lys Gln Ala Asn Asn Asn Ile Asp Ala Arg Ile 
        755                 760                 765             


Pro His Gly Leu Lys Val Gln Pro His Phe Ile Glu Val Arg Gly Asn 
    770                 775                 780                 


Gly Ser Leu Thr Lys Thr Tyr Cys Tyr Lys Ala Cys Leu Thr Ala Gly 
785                 790                 795                 800 


Ser Gly Ser Asp Thr Phe Met Phe Tyr Asn Thr Gly Ala Gln Thr Gly 
                805                 810                 815     


Pro Gly Pro Ser Gly Ala Gln Ala Ala Val Thr Asp Ser Arg Asn Leu 
            820                 825                 830         


Thr Gly Gln Ser Gly Gln Asn Ala Gly Asn Leu Ile Ile Leu Lys Asn 
        835                 840                 845             


Glu Ala Val Ser Gln Asn Glu Val Arg Gln Trp Ser Gly Gly Leu Leu 
    850                 855                 860                 


Gln Thr His Ala Phe Val Thr His Pro Pro Ile Ser Cys Asp Leu Ala 
865                 870                 875                 880 


Leu Leu Ser His 
                


<210>  5257
<211>  963
<212>  PRT
<213>  Homo sapiens

<400>  5257

Met Val Gly Cys Gly Val Ala Val Leu Cys Leu Trp Val Ser Cys Gly 
1               5                   10                  15      


Ala Ala Ala Gly Gln Leu Glu Tyr Ser Val Pro Glu Glu Thr Glu Arg 
            20                  25                  30          


Gly Val Ala Val Gly Asn Leu Ser Ala Asp Leu Arg Leu Pro Ala Ala 
        35                  40                  45              


Ala Met Ser Ser Arg Asn Phe Arg Phe Leu Ser Ser His Arg Glu Leu 
    50                  55                  60                  


Tyr Phe Gly Val Asp Leu Pro Ser Gly Asn Leu Val Val Arg Glu Pro 
65                  70                  75                  80  


Ala Asp Arg Glu Gln Leu Cys Arg Ala Lys Ala Ala Cys Val Leu Thr 
                85                  90                  95      


Tyr Asp Leu Val Leu Glu Asp Pro Leu Glu Leu His Lys Ile Arg Ile 
            100                 105                 110         


His Val Leu Asp Thr Asn Asp Asn Ser Pro Leu Phe Pro Ala Gly Asp 
        115                 120                 125             


Val Gln Leu His Ile Pro Glu Phe Leu Thr Pro Gly Ala Arg Phe Thr 
    130                 135                 140                 


Leu Pro Asn Ala Gln Asp Asp Asp Glu Gly Ser Asn Gly Ile Leu Ser 
145                 150                 155                 160 


Tyr Ser Leu Ser Pro Ser Gln His Phe Arg Leu Asp Met Gly Ser Arg 
                165                 170                 175     


Val Asp Gly Ser Glu Tyr Pro Glu Leu Val Leu Glu Lys Ala Leu Asp 
            180                 185                 190         


Arg Glu Gln Arg Ala Thr His Leu Leu Val Leu Thr Ala Arg Asp Gly 
        195                 200                 205             


Gly Leu Pro Ala Arg Ser Gly Asp Ala Gln Val Thr Ile Ile Val Val 
    210                 215                 220                 


Asp Thr Asn Asp Asn Ala Pro Val Phe Glu Arg Ser Val Tyr Arg Thr 
225                 230                 235                 240 


Lys Val Pro Glu Thr Ala Pro Asn Gly Thr Val Leu Phe Arg Val Gln 
                245                 250                 255     


Ala Leu Asp Pro Asp Glu Gly Ser Asn Gly Glu Val Gln Tyr Ser Leu 
            260                 265                 270         


Ser Asn Ser Thr Gln Ala Glu Leu Arg His Arg Phe His Val His Pro 
        275                 280                 285             


Lys Ser Gly Glu Val Gln Val Ala Ala Ser Leu Gly Pro Pro Glu Thr 
    290                 295                 300                 


Leu Leu Glu Ala Tyr Ile Glu Ala Arg Asp Glu Gly Val Phe Gly Leu 
305                 310                 315                 320 


Ala Ser Thr Ala Lys Leu Leu Val Glu Val Thr Asp Val Asn Asp His 
                325                 330                 335     


Ala Pro Glu Leu Asp Phe Leu Thr Leu Ser Asn Pro Val Pro Glu Asp 
            340                 345                 350         


Ala Ala Pro Gly Thr Val Ile Ala Leu Phe Ser Val Lys Asp Glu Asp 
        355                 360                 365             


Leu Asp Ser Asn Gly Arg Val Ile Cys Gly Met Ser Ser Ala Gly Pro 
    370                 375                 380                 


Phe Gln Leu Thr Ala Ser Phe Asp Asn Tyr Tyr Ser Leu Leu Ile Asp 
385                 390                 395                 400 


Gly Pro Leu Asp Arg Glu Gln Ile Ser Glu Tyr Gln Val Leu Ile Thr 
                405                 410                 415     


Ala Ser Asp Ser Gly Ser Pro Pro Leu Ser Thr Arg Arg Thr Ile Thr 
            420                 425                 430         


Val Ser Val Ala Asp Val Asn Asp Asn Thr Pro Asn Phe Pro Gln Pro 
        435                 440                 445             


Gln Gln Glu Leu Phe Val Ala Glu Asn Asn Gly Pro Gly Ala Ser Leu 
    450                 455                 460                 


Gly Arg Val Phe Ala Gln Asp Pro Asp Leu Gly Lys Asn Gly Leu Val 
465                 470                 475                 480 


Ser Tyr Glu Leu Leu Asp Val Ile Ser Glu Gly Pro Ser Ala Ser Ser 
                485                 490                 495     


Leu Leu Ala Val Glu Ser Ser Ser Gly Ala Ile Thr Ala Lys Thr Ser 
            500                 505                 510         


Phe Asp Phe Glu Gln Leu Arg Gly Phe His Phe Gln Val Glu Gly Arg 
        515                 520                 525             


Asp Gly Gly Ile Pro Pro Arg Ser Ala Thr Val Thr Ile Asn Leu Phe 
    530                 535                 540                 


Val Val Asp Arg Asn Asp Asn Tyr Pro Val Ile Leu Phe Pro Leu Pro 
545                 550                 555                 560 


Arg Asn Gly Ser Val Pro Val Glu Ile Val Pro Arg Ser Ala Arg Thr 
                565                 570                 575     


Gly His Leu Val Thr Lys Val Val Ala Glu Asp Ala Asp Ser Gly Ser 
            580                 585                 590         


Asn Ala Trp Leu Ser Tyr His Ile Ser Arg Ala Ser Asp Ser Ser Leu 
        595                 600                 605             


Phe Arg Ile Ser Ala Asn Ile Gly Glu Leu Arg Thr Ala Arg Leu Val 
    610                 615                 620                 


Leu Pro Thr Asp Ala Val Lys Gln Arg Val Val Val Val Val Arg Asp 
625                 630                 635                 640 


His Gly Asp Pro Pro Leu Ser Ser Ser Val Thr Leu Gly Val Leu Leu 
                645                 650                 655     


Ser Asn Ser Val Pro Gln Leu Leu Pro Asp Phe Glu Asp Val Trp Glu 
            660                 665                 670         


Pro Gly Gly Gln Leu Ser Ala Gln Asn Leu Tyr Leu Val Ile Ala Leu 
        675                 680                 685             


Ala Cys Ile Ser Phe Leu Phe Leu Gly Cys Leu Leu Phe Phe Val Cys 
    690                 695                 700                 


Thr Lys Leu His Gln Ser Pro Gly Cys Cys Ala Gln Ser Cys Cys Arg 
705                 710                 715                 720 


Ser Thr Glu Asp Leu Arg Tyr Gly Ser Lys Met Val Ser Asn Pro Cys 
                725                 730                 735     


Met Thr Ser Ala Thr Ile Asp Val Thr Thr Val Glu Arg Leu Ser Gln 
            740                 745                 750         


Thr Tyr Leu Tyr Arg Ala Ser Leu Gly Leu Gly Ser Asp Asn Asn Ser 
        755                 760                 765             


Leu Leu Leu Arg Gly Glu Tyr Asn Ala Ala Asp Leu Arg Asn Leu Ala 
    770                 775                 780                 


Thr Gly Val Gly Leu Asn Leu Pro Ile Ser Cys Ile Gln Ile Arg Asn 
785                 790                 795                 800 


Arg Lys Gly Asp His Ala Asn Val Asn Ala Met Pro Arg Gln Pro Asn 
                805                 810                 815     


Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser 
            820                 825                 830         


Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro 
        835                 840                 845             


Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala 
    850                 855                 860                 


Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp 
865                 870                 875                 880 


Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu 
                885                 890                 895     


Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile 
            900                 905                 910         


Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr 
        915                 920                 925             


Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly 
    930                 935                 940                 


Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn 
945                 950                 955                 960 


Ser Asp Gln 
            


<210>  5258
<211>  948
<212>  PRT
<213>  Homo sapiens

<400>  5258

Met Val Ser Arg Cys Ser Cys Leu Gly Val Gln Cys Leu Leu Leu Ser 
1               5                   10                  15      


Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His Tyr 
            20                  25                  30          


Ser Val Tyr Glu Glu Ala Arg His Gly Thr Phe Val Gly Arg Ile Ala 
        35                  40                  45              


Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Gln Arg Leu Phe Arg 
    50                  55                  60                  


Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln Asn 
65                  70                  75                  80  


Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys Gly 
                85                  90                  95      


Arg Ser Val Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg Pro 
            100                 105                 110         


Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp Asn 
        115                 120                 125             


Pro Pro Arg Phe Ser Val Thr Glu Gln Lys Leu Ser Ile Pro Glu Ser 
    130                 135                 140                 


Arg Leu Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala Asp 
145                 150                 155                 160 


Val Gly Glu Asn Ala Leu Leu Thr Tyr Lys Leu Ser Pro Asn Glu Tyr 
                165                 170                 175     


Phe Val Leu Asp Ile Ile Asn Lys Lys Asp Lys Asp Lys Phe Pro Val 
            180                 185                 190         


Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Glu Asn Pro Gln Leu Lys 
        195                 200                 205             


Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Phe Thr Gly Ser 
    210                 215                 220                 


Val Ser Leu Leu Ile Leu Val Leu Asp Ala Asn Asp Asn Ala Pro Ile 
225                 230                 235                 240 


Phe Asp Arg Pro Val Tyr Glu Val Lys Met Tyr Glu Asn Gln Val Asn 
                245                 250                 255     


Gln Thr Leu Val Ile Arg Leu Asn Ala Ser Asp Ser Asp Glu Gly Ile 
            260                 265                 270         


Asn Lys Glu Met Met Tyr Ser Phe Ser Ser Leu Val Pro Pro Thr Ile 
        275                 280                 285             


Arg Arg Lys Phe Trp Ile Asn Glu Arg Thr Gly Glu Ile Lys Val Asn 
    290                 295                 300                 


Asp Ala Ile Asp Phe Glu Asp Ser Asn Thr Tyr Glu Ile His Val Asp 
305                 310                 315                 320 


Val Thr Asp Lys Gly Asn Pro Pro Met Val Gly His Cys Thr Val Leu 
                325                 330                 335     


Val Glu Leu Leu Asp Glu Asn Asp Asn Ser Pro Glu Val Ile Val Thr 
            340                 345                 350         


Ser Leu Ser Leu Pro Val Lys Glu Asp Ala Gln Val Gly Thr Val Ile 
        355                 360                 365             


Ala Leu Ile Ser Val Ser Asp His Asp Ser Gly Ala Asn Gly Gln Val 
    370                 375                 380                 


Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr Tyr 
385                 390                 395                 400 


Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu Arg 
                405                 410                 415     


Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser Pro 
            420                 425                 430         


Pro Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Ala Phe Ala Gln Ser Glu Tyr Thr Val Phe Val Lys 
    450                 455                 460                 


Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp Asp 
465                 470                 475                 480 


Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu Arg 
                485                 490                 495     


Arg Leu Gly Glu Arg Ser Leu Ser Ser Tyr Val Ser Val His Ala Glu 
            500                 505                 510         


Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu Glu 
        515                 520                 525             


Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Gly Gly Val Pro Pro Leu 
    530                 535                 540                 


Gly Ser Asn Leu Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Leu Leu Ala Ser Pro Ala Gly Ser Ala Gly Gly Ala Val 
                565                 570                 575     


Ser Glu Leu Val Leu Arg Ser Val Val Ala Gly His Val Val Ala Lys 
            580                 585                 590         


Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Glu Leu Gln Ser Ala Ala Val Gly Ala Arg Ile Pro Phe Arg Val Gly 
    610                 615                 620                 


Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr Asp 
625                 630                 635                 640 


Ser Pro Arg Gln Arg Leu Leu Val Leu Val Lys Asp His Gly Glu Pro 
                645                 650                 655     


Ser Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Gly Ser 
            660                 665                 670         


Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Val Gly Val Ala Pro Glu 
        675                 680                 685             


Val Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile Cys Ala 
    690                 695                 700                 


Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala Leu Arg 
705                 710                 715                 720 


Cys Ser Ala Ala Pro Thr Glu Gly Ala Cys Gly Pro Val Lys Pro Thr 
                725                 730                 735     


Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln Gln Arg 
            740                 745                 750         


Arg Gln Arg Val Cys Ser Gly Glu Gly Leu Pro Lys Ala Asp Leu Met 
        755                 760                 765             


Ala Phe Ser Pro Ser Leu Pro Pro Cys Pro Met Val Asp Val Asp Gly 
    770                 775                 780                 


Glu Asp Gln Ser Ile Gly Gly Asp His Ser Arg Lys Pro Arg Gln Pro 
785                 790                 795                 800 


Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser 
                805                 810                 815     


Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly 
            820                 825                 830         


Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu 
        835                 840                 845             


Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser 
    850                 855                 860                 


Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly 
865                 870                 875                 880 


Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser 
                885                 890                 895     


Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile 
            900                 905                 910         


Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp 
    930                 935                 940                 


Asn Ser Asp Gln 
945             


<210>  5259
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  5259

Met Glu Pro Arg Cys Pro Pro Pro Cys Gly Cys Cys Glu Arg Leu Val 
1               5                   10                  15      


Leu Asn Val Ala Gly Leu Arg Phe Glu Thr Arg Ala Arg Thr Leu Gly 
            20                  25                  30          


Arg Phe Pro Asp Thr Leu Leu Gly Asp Pro Ala Arg Arg Gly Arg Phe 
        35                  40                  45              


Tyr Asp Asp Ala Arg Arg Glu Tyr Phe Phe Asp Arg His Arg Pro Ser 
    50                  55                  60                  


Phe Asp Ala Val Leu Tyr Tyr Tyr Gln Ser Gly Gly Arg Leu Arg Arg 
65                  70                  75                  80  


Pro Ala His Val Pro Leu Asp Val Phe Leu Glu Glu Val Ala Phe Tyr 
                85                  90                  95      


Gly Leu Gly Ala Ala Ala Leu Ala Arg Leu Arg Glu Asp Glu Gly Cys 
            100                 105                 110         


Pro Val Pro Pro Glu Arg Pro Leu Pro Arg Arg Ala Phe Ala Arg Gln 
        115                 120                 125             


Leu Trp Leu Leu Phe Glu Phe Pro Glu Ser Ser Gln Ala Ala Arg Val 
    130                 135                 140                 


Leu Ala Val Val Ser Val Leu Val Ile Leu Val Ser Ile Val Val Phe 
145                 150                 155                 160 


Cys Leu Glu Thr Leu Pro Asp Phe Arg Asp Asp Arg Asp Gly Thr Gly 
                165                 170                 175     


Leu Ala Ala Ala Ala Ala Ala Gly Pro Phe Pro Ala Pro Leu Asn Gly 
            180                 185                 190         


Ser Ser Gln Met Pro Gly Asn Pro Pro Arg Leu Pro Phe Asn Asp Pro 
        195                 200                 205             


Phe Phe Val Val Glu Thr Leu Cys Ile Cys Trp Phe Ser Phe Glu Leu 
    210                 215                 220                 


Leu Val Arg Leu Leu Val Cys Pro Ser Lys Ala Ile Phe Phe Lys Asn 
225                 230                 235                 240 


Val Met Asn Leu Ile Asp Phe Val Ala Ile Leu Pro Tyr Phe Val Ala 
                245                 250                 255     


Leu Gly Thr Glu Leu Ala Arg Gln Arg Gly Val Gly Gln Gln Ala Met 
            260                 265                 270         


Ser Leu Ala Ile Leu Arg Val Ile Arg Leu Val Arg Val Phe Arg Ile 
        275                 280                 285             


Phe Lys Leu Ser Arg His Ser Lys Gly Leu Gln Ile Leu Gly Gln Thr 
    290                 295                 300                 


Leu Arg Ala Ser Met Arg Glu Leu Gly Leu Leu Ile Phe Phe Leu Phe 
305                 310                 315                 320 


Ile Gly Val Val Leu Phe Ser Ser Ala Val Tyr Phe Ala Glu Val Asp 
                325                 330                 335     


Arg Val Asp Ser His Phe Thr Ser Ile Pro Glu Ser Phe Trp Trp Ala 
            340                 345                 350         


Val Val Thr Met Thr Thr Val Gly Tyr Gly Asp Met Ala Pro Val Thr 
        355                 360                 365             


Val Gly Gly Lys Ile Val Gly Ser Leu Cys Ala Ile Ala Gly Val Leu 
    370                 375                 380                 


Thr Ile Ser Leu Pro Val Pro Val Ile Val Ser Asn Phe Ser Tyr Phe 
385                 390                 395                 400 


Tyr His Arg Glu Thr Glu Gly Glu Glu Ala Gly Met Phe Ser His Val 
                405                 410                 415     


Asp Met Gln Pro Cys Gly Pro Leu Glu Gly Lys Ala Asn Gly Gly Leu 
            420                 425                 430         


Val Asp Gly Glu Val Pro Glu Leu Pro Pro Pro Leu Trp Ala Pro Pro 
        435                 440                 445             


Gly Lys His Leu Val Thr Glu Val 
    450                 455     


<210>  5260
<211>  578
<212>  PRT
<213>  Homo sapiens

<400>  5260

Met Arg Pro Ala Leu Gly His Pro Arg Ser Val Ser Ser Ala Ser Gly 
1               5                   10                  15      


Ser Phe Pro Pro Pro Pro Ala Ala Ala Arg Leu Gln Pro Leu Phe Leu 
            20                  25                  30          


Arg Gly Gly Ser Phe Arg Gly Arg Arg Gly Ser Gly Asp Ser Ser Thr 
        35                  40                  45              


Ser Thr Ser Thr Ser Arg Gly Gly Gly Gly Gly Arg Arg Gly Gly Gly 
    50                  55                  60                  


Gly Gly Ser Pro Ser Ser Ser Thr Gly Ala Glu Arg Glu Asp Asp Asp 
65                  70                  75                  80  


Glu Ser Leu Ser Val Ser Lys Pro Leu Val Pro Asn Ala Ala Leu Leu 
                85                  90                  95      


Gly Pro Pro Ala Gln Val Gly Ala Pro Ala Gly Pro Ala Pro Val Ala 
            100                 105                 110         


Phe Ser Ser Ser Ala Ala Thr Ser Ser Ser Thr Ser Thr Pro Thr Ser 
        115                 120                 125             


Ser Cys Ser Met Thr Ala Ala Asp Phe Gly Gly Gly Ala Ala Ala Gly 
    130                 135                 140                 


Ala Val Gly Gly Pro Gly Ser Arg Ser Ala Gly Gly Ala Gly Gly Thr 
145                 150                 155                 160 


Gly Thr Gly Ser Gly Ala Ser Cys Cys Pro Cys Cys Cys Cys Cys Gly 
                165                 170                 175     


Cys Pro Asp Arg Pro Gly Arg Arg Gly Arg Arg Arg Gly Cys Ala Pro 
            180                 185                 190         


Ser Pro Arg Cys Arg Trp Gly Tyr Gln Ala Leu Ser Val Val Leu Leu 
        195                 200                 205             


Leu Ala Gln Gly Gly Leu Leu Asp Leu Tyr Leu Ile Ala Val Thr Asp 
    210                 215                 220                 


Leu Tyr Trp Cys Ser Trp Ile Ala Thr Asp Leu Val Val Val Val Gly 
225                 230                 235                 240 


Trp Ala Ile Phe Phe Ala Lys Asn Ser Arg Gly Arg Arg Gly Gly Ala 
                245                 250                 255     


Ala Ser Gly Ala His Asn His His Leu His His His His Ala Ala Pro 
            260                 265                 270         


Pro Leu His Leu Pro Ala Pro Ser Ala Ala Thr Ala Gly Ala Lys Ala 
        275                 280                 285             


Arg Gly Ala Arg Gly Gly Ala Gly Gly Ala Gly Gly Gly Leu Gly Ala 
    290                 295                 300                 


Ala Ala Ala Ala Gly Glu Phe Ala Phe Ala Tyr Leu Ala Trp Leu Ile 
305                 310                 315                 320 


Tyr Ser Ile Ala Phe Thr Pro Lys Val Val Leu Ile Leu Gly Thr Ser 
                325                 330                 335     


Ile Leu Asp Leu Ile Glu Leu Arg Ala Pro Phe Gly Thr Thr Gly Phe 
            340                 345                 350         


Arg Leu Thr Met Ala Leu Ser Val Pro Leu Leu Tyr Ser Leu Val Arg 
        355                 360                 365             


Ala Ile Ser Glu Ala Gly Ala Pro Pro Gly Ser Ala Gly Pro Leu Leu 
    370                 375                 380                 


Leu Gln Pro Gln Arg His Arg Ala Ala Gly Cys Phe Leu Gly Thr Cys 
385                 390                 395                 400 


Leu Asp Leu Leu Asp Ser Phe Thr Leu Val Glu Leu Met Leu Glu Gly 
                405                 410                 415     


Arg Val Pro Leu Pro Ala His Leu Arg Tyr Leu Leu Ile Ala Val Tyr 
            420                 425                 430         


Phe Leu Thr Leu Ala Ser Pro Val Leu Trp Leu Tyr Glu Leu Asn Ala 
        435                 440                 445             


Ala Ala Ala Ala Ala Ala Ser Trp Gly Gln Ala Ser Gly Pro Gly Ser 
    450                 455                 460                 


Cys Ser Arg Leu Leu Arg Leu Leu Gly Gly Cys Leu Val Asp Val Pro 
465                 470                 475                 480 


Leu Leu Ala Leu Arg Cys Leu Leu Val Val Ser Tyr Gln Gln Pro Leu 
                485                 490                 495     


Ser Ile Phe Met Leu Lys Asn Leu Phe Phe Leu Gly Cys Arg Gly Leu 
            500                 505                 510         


Glu Ala Leu Glu Gly Cys Trp Asp Arg Gly Asn Arg Ala Ser Pro Ser 
        515                 520                 525             


Arg Ala Arg Gly Gly Tyr Gly Ala Pro Pro Ser Ala Pro Pro Pro Pro 
    530                 535                 540                 


Pro Pro Pro Pro Gln Gly Gly Ser Gln Leu Gly His Cys Ile Ser Glu 
545                 550                 555                 560 


Asn Glu Gly Gly Ala His Gly Tyr Val Asn Thr Leu Ala Val Ala Ser 
                565                 570                 575     


Gln Asn 
        


<210>  5261
<211>  801
<212>  PRT
<213>  Homo sapiens

<400>  5261

Met Trp Thr Ser Gly Arg Met Ser Asn Ala Lys Asn Trp Leu Gly Leu 
1               5                   10                  15      


Gly Met Ser Leu Tyr Phe Trp Gly Leu Met Asp Leu Thr Thr Thr Val 
            20                  25                  30          


Leu Ser Asp Thr Pro Thr Pro Gln Gly Glu Leu Glu Ala Leu Leu Ser 
        35                  40                  45              


Asp Lys Pro Gln Ser His Gln Arg Thr Lys Arg Ser Trp Val Trp Asn 
    50                  55                  60                  


Gln Phe Phe Val Leu Glu Glu Tyr Thr Gly Thr Asp Pro Leu Tyr Val 
65                  70                  75                  80  


Gly Lys Leu His Ser Asp Met Asp Arg Gly Asp Gly Ser Ile Lys Tyr 
                85                  90                  95      


Ile Leu Ser Gly Glu Gly Ala Gly Ile Val Phe Thr Ile Asp Asp Thr 
            100                 105                 110         


Thr Gly Asp Ile His Ala Ile Gln Arg Leu Asp Arg Glu Glu Arg Ala 
        115                 120                 125             


Gln Tyr Thr Leu Arg Ala Gln Ala Leu Asp Arg Arg Thr Gly Arg Pro 
    130                 135                 140                 


Met Glu Pro Glu Ser Glu Phe Ile Ile Lys Ile Gln Asp Ile Asn Asp 
145                 150                 155                 160 


Asn Glu Pro Lys Phe Leu Asp Gly Pro Tyr Val Ala Thr Val Pro Glu 
                165                 170                 175     


Met Ser Pro Val Gly Thr Ser Val Ile Gln Val Thr Ala Thr Asp Ala 
            180                 185                 190         


Asp Asp Pro Thr Tyr Gly Asn Ser Ala Arg Val Val Tyr Ser Ile Leu 
        195                 200                 205             


Gln Gly Gln Pro Tyr Phe Ser Val Asp Ser Lys Thr Gly Val Ile Arg 
    210                 215                 220                 


Thr Ala Leu Met Asn Met Asp Arg Glu Ala Lys Glu Tyr Tyr Glu Val 
225                 230                 235                 240 


Ile Ile Gln Ala Lys Asp Met Gly Gly Gln Leu Gly Gly Leu Ala Gly 
                245                 250                 255     


Thr Thr Thr Val Asn Ile Thr Leu Ser Asp Val Asn Asp Asn Pro Pro 
            260                 265                 270         


Arg Phe Pro Gln Lys His Tyr Gln Met Ser Val Leu Glu Ser Ala Pro 
        275                 280                 285             


Ile Ser Ser Thr Val Gly Arg Val Phe Ala Lys Asp Leu Asp Glu Gly 
    290                 295                 300                 


Ile Asn Ala Glu Met Lys Tyr Thr Ile Val Asp Gly Asp Gly Ala Asp 
305                 310                 315                 320 


Ala Phe Asp Ile Ser Thr Asp Pro Asn Phe Gln Val Gly Ile Ile Thr 
                325                 330                 335     


Val Lys Lys Pro Leu Ser Phe Glu Ser Lys Lys Ser Tyr Thr Leu Lys 
            340                 345                 350         


Val Glu Gly Ala Asn Pro His Leu Glu Met Arg Phe Leu Asn Leu Gly 
        355                 360                 365             


Pro Phe Gln Asp Thr Thr Thr Val His Ile Ser Val Glu Asp Val Asp 
    370                 375                 380                 


Glu Pro Pro Val Phe Glu Pro Gly Phe Tyr Phe Val Glu Val Pro Glu 
385                 390                 395                 400 


Asp Val Ala Ile Gly Thr Thr Ile Gln Ile Ile Ser Ala Lys Asp Pro 
                405                 410                 415     


Asp Val Thr Asn Asn Ser Ile Arg Tyr Ser Ile Asp Arg Ser Ser Asp 
            420                 425                 430         


Pro Gly Arg Phe Phe Tyr Val Asp Ile Thr Thr Gly Ala Leu Met Thr 
        435                 440                 445             


Ala Arg Pro Leu Asp Arg Glu Glu Phe Ser Trp His Asn Ile Thr Val 
    450                 455                 460                 


Leu Ala Met Glu Met Asn Asn Pro Ser Gln Val Gly Ser Val Pro Val 
465                 470                 475                 480 


Thr Ile Lys Val Leu Asp Val Asn Asp Asn Ala Pro Glu Phe Pro Arg 
                485                 490                 495     


Phe Tyr Glu Ala Phe Val Cys Glu Asn Ala Lys Ala Gly Gln Leu Ile 
            500                 505                 510         


Gln Thr Val Ser Ala Val Asp Gln Asp Asp Pro Arg Asn Gly Gln His 
        515                 520                 525             


Phe Tyr Tyr Ser Leu Ala Pro Glu Ala Ala Asn Asn Pro Asn Phe Thr 
    530                 535                 540                 


Ile Arg Asp Asn Gln Asp Asn Thr Ala Arg Ile Leu Thr Arg Arg Ser 
545                 550                 555                 560 


Gly Phe Arg Gln Gln Glu Gln Ser Val Phe His Leu Pro Ile Leu Ile 
                565                 570                 575     


Ala Asp Ser Gly Gln Pro Val Leu Ser Ser Thr Gly Thr Leu Thr Ile 
            580                 585                 590         


Gln Val Cys Ser Cys Asp Asp Asp Gly His Val Met Ser Cys Ser Pro 
        595                 600                 605             


Glu Ala Tyr Met Leu Pro Val Ser Leu Ser Arg Gly Ala Leu Ile Ala 
    610                 615                 620                 


Ile Leu Ala Cys Ile Phe Val Leu Leu Val Leu Val Leu Leu Ile Leu 
625                 630                 635                 640 


Ser Met Arg Arg His Arg Lys Gln Pro Tyr Ile Ile Asp Asp Glu Glu 
                645                 650                 655     


Asn Ile His Glu Asn Ile Val Arg Tyr Asp Asp Glu Gly Gly Gly Glu 
            660                 665                 670         


Glu Asp Thr Glu Ala Phe Asp Ile Ala Ala Met Trp Asn Pro Arg Glu 
        675                 680                 685             


Ala Gln Ala Gly Ala Ala Pro Lys Thr Arg Gln Asp Met Leu Pro Glu 
    690                 695                 700                 


Ile Glu Ser Leu Ser Arg Tyr Val Pro Gln Thr Cys Ala Val Asn Ser 
705                 710                 715                 720 


Thr Val His Ser Tyr Val Leu Ala Lys Leu Tyr Glu Ala Asp Met Asp 
                725                 730                 735     


Leu Trp Ala Pro Pro Phe Asp Ser Leu Gln Thr Tyr Met Phe Glu Gly 
            740                 745                 750         


Asp Gly Ser Val Ala Gly Ser Leu Ser Ser Leu Gln Ser Ala Thr Ser 
        755                 760                 765             


Asp Ser Glu Gln Ser Phe Asp Phe Leu Thr Asp Trp Gly Pro Arg Phe 
    770                 775                 780                 


Arg Lys Leu Ala Glu Leu Tyr Gly Ala Ser Glu Gly Pro Ala Pro Leu 
785                 790                 795                 800 


Trp 
    


<210>  5262
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  5262

Met Ala Thr Ala Gln Pro Ser Gln Val Arg Gln Lys Tyr Asp Thr Asn 
1               5                   10                  15      


Cys Asp Ala Ala Ile Asn Ser His Ile Thr Leu Glu Leu Tyr Thr Ser 
            20                  25                  30          


Tyr Leu Tyr Leu Ser Met Ala Phe Tyr Phe Asn Arg Asp Asp Val Ala 
        35                  40                  45              


Leu Glu Asn Phe Phe Arg Tyr Phe Leu Arg Leu Ser Asp Asp Lys Met 
    50                  55                  60                  


Glu His Ala Gln Lys Leu Met Arg Leu Gln Asn Leu Arg Gly Gly His 
65                  70                  75                  80  


Ile Cys Leu His Asp Ile Arg Lys Pro Glu Cys Gln Gly Trp Glu Ser 
                85                  90                  95      


Gly Leu Val Ala Met Glu Ser Ala Phe His Leu Glu Lys Asn Val Asn 
            100                 105                 110         


Gln Ser Leu Leu Asp Leu Tyr Gln Leu Ala Val Glu Lys Gly Asp Pro 
        115                 120                 125             


Gln Leu Cys His Phe Leu Glu Ser His Tyr Leu His Glu Gln Val Lys 
    130                 135                 140                 


Thr Ile Lys Glu Leu Gly Gly Tyr Val Ser Asn Leu Arg Lys Ile Cys 
145                 150                 155                 160 


Ser Pro Glu Ala Gly Leu Ala Glu Tyr Leu Phe Asp Lys Leu Thr Leu 
                165                 170                 175     


Gly Gly Arg Val Lys Glu Thr 
            180             


<210>  5263
<211>  425
<212>  PRT
<213>  Homo sapiens

<400>  5263

Met Glu Ser Leu Lys Arg Trp Asn Glu Glu Arg Gly Leu Trp Cys Glu 
1               5                   10                  15      


Lys Gly Val Gln Val Leu Leu Thr Thr Val Gly Ala Phe Ala Ala Phe 
            20                  25                  30          


Gly Leu Met Thr Ile Ala Ile Ser Thr Asp Tyr Trp Leu Tyr Thr Arg 
        35                  40                  45              


Ala Leu Ile Cys Asn Thr Thr Asn Leu Thr Ala Gly Gly Asp Asp Gly 
    50                  55                  60                  


Thr Pro His Arg Gly Gly Gly Gly Ala Ser Glu Lys Lys Asp Pro Gly 
65                  70                  75                  80  


Gly Leu Thr His Ser Gly Leu Trp Arg Ile Cys Cys Leu Glu Gly Leu 
                85                  90                  95      


Lys Arg Gly Val Cys Val Lys Ile Asn His Phe Pro Glu Asp Thr Asp 
            100                 105                 110         


Tyr Asp His Asp Ser Ala Glu Tyr Leu Leu Arg Val Val Arg Ala Ser 
        115                 120                 125             


Ser Ile Phe Pro Ile Leu Ser Ala Ile Leu Leu Leu Leu Gly Gly Val 
    130                 135                 140                 


Cys Val Ala Ala Ser Arg Val Tyr Lys Ser Lys Arg Asn Ile Ile Leu 
145                 150                 155                 160 


Gly Ala Gly Ile Leu Phe Val Ala Ala Gly Leu Ser Asn Ile Ile Gly 
                165                 170                 175     


Val Ile Val Tyr Ile Ser Ala Asn Ala Gly Glu Pro Gly Pro Lys Arg 
            180                 185                 190         


Asp Glu Glu Lys Lys Asn His Tyr Ser Tyr Gly Trp Ser Phe Tyr Phe 
        195                 200                 205             


Gly Gly Leu Ser Phe Ile Leu Ala Glu Val Ile Gly Val Leu Ala Val 
    210                 215                 220                 


Asn Ile Tyr Ile Glu Arg Ser Arg Glu Ala His Cys Gln Ser Arg Ser 
225                 230                 235                 240 


Asp Leu Leu Lys Ala Gly Gly Gly Ala Gly Gly Ser Gly Gly Ser Gly 
                245                 250                 255     


Pro Ser Ala Ile Leu Arg Leu Pro Ser Tyr Arg Phe Arg Tyr Arg Arg 
            260                 265                 270         


Arg Ser Arg Ser Ser Ser Arg Ser Ser Glu Pro Ser Pro Ser Arg Asp 
        275                 280                 285             


Ala Ser Pro Gly Gly Pro Gly Gly Pro Gly Phe Ala Ser Thr Asp Ile 
    290                 295                 300                 


Ser Met Tyr Thr Leu Ser Arg Asp Pro Ser Lys Gly Ser Val Ala Ala 
305                 310                 315                 320 


Gly Leu Ala Gly Ala Gly Gly Gly Gly Gly Gly Ala Val Gly Ala Phe 
                325                 330                 335     


Gly Gly Ala Ala Gly Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly 
            340                 345                 350         


Ala Gly Ala Glu Arg Asp Arg Gly Gly Ala Ser Gly Phe Leu Thr Leu 
        355                 360                 365             


His Asn Ala Phe Pro Lys Glu Ala Gly Gly Gly Val Thr Val Thr Val 
    370                 375                 380                 


Thr Gly Pro Pro Ala Pro Pro Ala Pro Ala Pro Pro Ala Pro Ser Ala 
385                 390                 395                 400 


Pro Ala Pro Gly Thr Leu Ala Lys Glu Ala Ala Ala Ser Asn Thr Asn 
                405                 410                 415     


Thr Leu Asn Arg Lys Thr Thr Pro Val 
            420                 425 


<210>  5264
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  5264

Met Ser His Cys Ser Ser Arg Ala Leu Thr Leu Leu Ser Ser Val Phe 
1               5                   10                  15      


Gly Ala Cys Gly Leu Leu Leu Val Gly Ile Ala Val Ser Thr Asp Tyr 
            20                  25                  30          


Trp Leu Tyr Met Glu Glu Gly Thr Val Leu Pro Gln Asn Gln Thr Thr 
        35                  40                  45              


Glu Val Lys Met Ala Leu His Ala Gly Leu Trp Arg Val Cys Phe Phe 
    50                  55                  60                  


Ala Gly Arg Glu Lys Gly Arg Cys Val Ala Ser Glu Tyr Phe Leu Glu 
65                  70                  75                  80  


Pro Glu Ile Asn Leu Val Thr Glu Asn Thr Glu Asn Ile Leu Lys Thr 
                85                  90                  95      


Val Arg Thr Ala Thr Pro Phe Pro Met Val Ser Leu Phe Leu Val Phe 
            100                 105                 110         


Thr Ala Phe Val Ile Ser Asn Ile Gly His Ile Arg Pro Gln Arg Thr 
        115                 120                 125             


Ile Leu Ala Phe Val Ser Gly Ile Phe Phe Ile Leu Ser Gly Leu Ser 
    130                 135                 140                 


Leu Val Val Gly Leu Val Leu Tyr Ile Ser Ser Ile Asn Asp Glu Val 
145                 150                 155                 160 


Met Asn Arg Pro Ser Ser Ser Glu Gln Tyr Phe His Tyr Arg Tyr Gly 
                165                 170                 175     


Trp Ser Phe Ala Phe Ala Ala Ser Ser Phe Leu Leu Lys Glu Gly Ala 
            180                 185                 190         


Gly Val Met Ser Val Tyr Leu Phe Thr Lys Arg Tyr Ala Glu Glu Glu 
        195                 200                 205             


Met Tyr Arg Pro His Pro Ala Phe Tyr Arg Pro Arg Leu Ser Asp Cys 
    210                 215                 220                 


Ser Asp Tyr Ser Gly Gln Phe Leu Gln Pro Glu Ala Trp Arg Arg Gly 
225                 230                 235                 240 


Arg Ser Pro Ser Asp Ile Ser Ser Asp Val Ser Ile Gln Met Thr Gln 
                245                 250                 255     


Asn Tyr Pro Pro Ala Ile Lys Tyr Pro Asp His Leu His Ile Ser Thr 
            260                 265                 270         


Ser Pro Cys 
        275 


<210>  5265
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  5265

Met Met Trp Ser Asn Phe Phe Leu Gln Glu Glu Asn Arg Arg Arg Gly 
1               5                   10                  15      


Ala Ala Gly Arg Arg Arg Ala His Gly Gln Gly Arg Ser Gly Leu Thr 
            20                  25                  30          


Pro Glu Arg Glu Gly Lys Val Lys Leu Ala Leu Leu Leu Ala Ala Val 
        35                  40                  45              


Gly Ala Thr Leu Ala Val Leu Ser Val Gly Thr Glu Phe Trp Val Glu 
    50                  55                  60                  


Leu Asn Thr Tyr Lys Ala Asn Gly Ser Ala Val Cys Glu Ala Ala His 
65                  70                  75                  80  


Leu Gly Leu Trp Lys Ala Cys Thr Lys Arg Leu Trp Gln Ala Asp Val 
                85                  90                  95      


Pro Val Asp Arg Asp Thr Cys Gly Pro Ala Glu Leu Pro Gly Gly Leu 
            100                 105                 110         


Leu Leu Leu Val Ser Leu Glu Val Phe Arg His Ser Val Arg Ala Leu 
        115                 120                 125             


Leu Gln Arg Val Ser Pro Glu Pro Pro Pro Ala Pro Arg Leu Thr Tyr 
    130                 135                 140                 


Glu Tyr Ser Trp Ser Leu Gly Cys Gly Val Gly Ala Gly Leu Ile Leu 
145                 150                 155                 160 


Leu Leu Gly Ala Gly Cys Phe Leu Leu Leu Thr Leu Pro Ser Trp Pro 
                165                 170                 175     


Trp Gly Ser Leu Cys Pro Lys Arg Gly His Arg Ala Thr 
            180                 185                 


<210>  5266
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  5266

Met Gly Gly Pro Arg Gly Ala Gly Trp Val Ala Ala Gly Leu Leu Leu 
1               5                   10                  15      


Gly Ala Gly Ala Cys Tyr Cys Ile Tyr Arg Leu Thr Arg Gly Arg Arg 
            20                  25                  30          


Arg Gly Asp Arg Glu Leu Gly Ile Arg Ser Ser Lys Ser Ala Gly Ala 
        35                  40                  45              


Leu Glu Glu Gly Thr Ser Glu Gly Gln Leu Cys Gly Arg Ser Ala Arg 
    50                  55                  60                  


Pro Gln Thr Gly Gly Thr Trp Glu Ser Gln Trp Ser Lys Thr Ser Gln 
65                  70                  75                  80  


Pro Glu Asp Leu Thr Asp Gly Ser Tyr Asp Asp Val Leu Asn Ala Glu 
                85                  90                  95      


Gln Leu Gln Lys Leu Leu Tyr Leu Leu Glu Ser Thr Glu Asp Pro Val 
            100                 105                 110         


Ile Ile Glu Arg Ala Leu Ile Thr Leu Gly Asn Asn Ala Ala Phe Ser 
        115                 120                 125             


Val Asn Gln Ala Ile Ile Arg Glu Leu Gly Gly Ile Pro Ile Val Ala 
    130                 135                 140                 


Asn Lys Ile Asn His Ser Asn Gln Ser Ile Lys Glu Lys Ala Leu Asn 
145                 150                 155                 160 


Ala Leu Asn Asn Leu Ser Val Asn Val Glu Asn Gln Ile Lys Ile Lys 
                165                 170                 175     


Ile Tyr Ile Ser Gln Val Cys Glu Asp Val Phe Ser Gly Pro Leu Asn 
            180                 185                 190         


Ser Ala Val Gln Leu Ala Gly Leu Thr Leu Leu Thr Asn Met Thr Val 
        195                 200                 205             


Thr Asn Asp His Gln His Met Leu His Ser Tyr Ile Thr Asp Leu Phe 
    210                 215                 220                 


Gln Val Leu Leu Thr Gly Asn Gly Asn Thr Lys Val Gln Val Leu Lys 
225                 230                 235                 240 


Leu Leu Leu Asn Leu Ser Glu Asn Pro Ala Met Thr Glu Gly Leu Leu 
                245                 250                 255     


Arg Ala Gln Val Asp Ser Ser Phe Leu Ser Leu Tyr Asp Ser His Val 
            260                 265                 270         


Ala Lys Glu Ile Leu Leu Arg Val Leu Thr Leu Phe Gln Asn Ile Lys 
        275                 280                 285             


Asn Cys Leu Lys Ile Glu Gly His Leu Ala Val Gln Pro Thr Phe Thr 
    290                 295                 300                 


Glu Gly Ser Leu Phe Phe Leu Leu His Gly Glu Glu Cys Ala Gln Lys 
305                 310                 315                 320 


Ile Arg Ala Leu Val Asp His His Asp Ala Glu Val Lys Glu Lys Val 
                325                 330                 335     


Val Thr Ile Ile Pro Lys Ile 
            340             


<210>  5267
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  5267

Met Gln Trp Leu Arg Val Arg Glu Ser Pro Gly Glu Ala Thr Gly His 
1               5                   10                  15      


Arg Val Thr Met Gly Thr Ala Ala Leu Gly Pro Val Trp Ala Ala Leu 
            20                  25                  30          


Leu Leu Phe Leu Leu Met Cys Glu Ile Pro Met Val Glu Leu Thr Phe 
        35                  40                  45              


Asp Arg Ala Val Ala Ser Gly Cys Gln Arg Cys Cys Asp Ser Glu Asp 
    50                  55                  60                  


Pro Leu Asp Pro Ala His Val Ser Ser Ala Ser Ser Ser Gly Arg Pro 
65                  70                  75                  80  


His Ala Leu Pro Glu Ile Arg Pro Tyr Ile Asn Ile Thr Ile Leu Lys 
                85                  90                  95      


Gly Asp Lys Gly Asp Pro Gly Pro Met Gly Leu Pro Gly Tyr Met Gly 
            100                 105                 110         


Arg Glu Gly Pro Gln Gly Glu Pro Gly Pro Gln Gly Ser Lys Gly Asp 
        115                 120                 125             


Lys Gly Glu Met Gly Ser Pro Gly Ala Pro Cys Gln Lys Arg Phe Phe 
    130                 135                 140                 


Ala Phe Ser Val Gly Arg Lys Thr Ala Leu His Ser Gly Glu Asp Phe 
145                 150                 155                 160 


Gln Thr Leu Leu Phe Glu Arg Val Phe Val Asn Leu Asp Gly Cys Phe 
                165                 170                 175     


Asp Met Ala Thr Gly Gln Phe Ala Ala Pro Leu Arg Gly Ile Tyr Phe 
            180                 185                 190         


Phe Ser Leu Asn Val His Ser Trp Asn Tyr Lys Glu Thr Tyr Val His 
        195                 200                 205             


Ile Met His Asn Gln Lys Glu Ala Val Ile Leu Tyr Ala Gln Pro Ser 
    210                 215                 220                 


Glu Arg Ser Ile Met Gln Ser Gln Ser Val Met Leu Asp Leu Ala Tyr 
225                 230                 235                 240 


Gly Asp Arg Val Trp Val Arg Leu Phe Lys Arg Gln Arg Glu Asn Ala 
                245                 250                 255     


Ile Tyr Ser Asn Asp Phe Asp Thr Tyr Ile Thr Phe Ser Gly His Leu 
            260                 265                 270         


Ile Lys Ala Glu Asp Asp 
        275             


<210>  5268
<211>  421
<212>  PRT
<213>  Homo sapiens

<400>  5268

Met Ala Glu Gln Leu Ala Leu Val Ile Gly Gly Thr Ile Gly Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ile Gly Ala Ser Cys Cys Leu Trp Arg Arg Phe 
            20                  25                  30          


Cys Ala Thr Leu Thr Tyr Glu Glu Leu Pro Gly Thr Pro Ala Met Ala 
        35                  40                  45              


Thr Thr Ala Ala Ser Ser Gly Gln Arg Asp Arg Pro Cys Gln Pro His 
    50                  55                  60                  


Ala Arg Thr Gln Leu Ser Arg Pro Pro Ala Val Pro Phe Val Val Pro 
65                  70                  75                  80  


Pro Thr Leu Gln Gly Arg Asp Trp Val Pro Leu His Ser Gly Glu Trp 
                85                  90                  95      


Ala Asp Ala Pro Trp Asp Pro Cys Pro Ala Ser Glu Leu Leu Pro His 
            100                 105                 110         


Thr Ser Ser Gly Gly Leu Gly Asp Ala Cys Met Val Gly Ala Ile Asn 
        115                 120                 125             


Pro Glu Leu Tyr Lys Phe Pro Glu Asp Lys Ser Glu Thr Asp Phe Pro 
    130                 135                 140                 


Asp Gly Cys Leu Gly Arg Leu Trp Phe Ser Val Glu Tyr Glu Gln Glu 
145                 150                 155                 160 


Ala Glu Arg Leu Leu Val Gly Leu Ile Lys Ala Gln His Leu Gln Ala 
                165                 170                 175     


Pro Ser Glu Thr Cys Ser Pro Leu Val Lys Leu Tyr Leu Leu Pro Asp 
            180                 185                 190         


Glu Arg Arg Phe Leu Gln Ser Lys Thr Lys Arg Lys Thr Ser Asn Pro 
        195                 200                 205             


Gln Phe Asp Glu His Phe Ile Phe Gln Val Ser Ser Lys Thr Ile Thr 
    210                 215                 220                 


Gln Arg Val Leu Lys Phe Ser Val Tyr His Val Asp Arg Gln Arg Lys 
225                 230                 235                 240 


His Gln Leu Leu Gly Gln Val Leu Phe Pro Leu Lys Asn Glu Thr Leu 
                245                 250                 255     


Val Gly Asp Cys Arg Arg Val Ile Trp Arg Asp Leu Glu Ala Glu Ser 
            260                 265                 270         


Leu Glu Pro Pro Ser Glu Phe Gly Asp Leu Gln Phe Cys Leu Ser Tyr 
        275                 280                 285             


Asn Asp Tyr Leu Ser Arg Leu Thr Val Val Val Leu Arg Ala Lys Gly 
    290                 295                 300                 


Leu Arg Leu Gln Glu Asp Arg Gly Ile Val Ser Val Phe Val Lys Val 
305                 310                 315                 320 


Ser Leu Met Asn His Asn Lys Phe Val Lys Cys Lys Lys Thr Ser Ala 
                325                 330                 335     


Val Leu Gly Ser Ile Asn Pro Val Tyr Asn Glu Thr Phe Ser Phe Lys 
            340                 345                 350         


Ala Asp Ala Thr Glu Leu Asp Thr Ala Ser Leu Ser Leu Thr Val Val 
        355                 360                 365             


Gln Asn Met Glu Gly Asp Lys Ser Gln Gln Leu Gly Arg Val Val Val 
    370                 375                 380                 


Gly Pro Tyr Met Tyr Thr Arg Gly Arg Glu Leu Glu His Trp Asp Glu 
385                 390                 395                 400 


Met Leu Ser Lys Pro Lys Glu Leu Val Lys Arg Trp His Ala Leu Cys 
                405                 410                 415     


Arg Thr Thr Glu Pro 
            420     


<210>  5269
<211>  886
<212>  PRT
<213>  Homo sapiens

<400>  5269

Met Arg Ala Glu Glu Pro Cys Ala Pro Gly Ala Pro Ser Ala Leu Gly 
1               5                   10                  15      


Ala Gln Arg Thr Pro Gly Pro Glu Leu Arg Leu Ser Ser Gln Leu Leu 
            20                  25                  30          


Pro Glu Leu Cys Thr Phe Val Val Arg Val Leu Phe Tyr Leu Gly Pro 
        35                  40                  45              


Val Tyr Leu Ala Gly Tyr Leu Gly Leu Ser Ile Thr Trp Leu Leu Leu 
    50                  55                  60                  


Gly Ala Leu Leu Trp Met Trp Trp Arg Arg Asn Arg Arg Gly Lys Leu 
65                  70                  75                  80  


Gly Arg Leu Ala Ala Ala Phe Glu Phe Leu Asp Asn Glu Arg Glu Phe 
                85                  90                  95      


Ile Ser Arg Glu Leu Arg Gly Gln His Leu Pro Ala Trp Ile His Phe 
            100                 105                 110         


Pro Asp Val Glu Arg Val Glu Trp Ala Asn Lys Ile Ile Ser Gln Thr 
        115                 120                 125             


Trp Pro Tyr Leu Ser Met Ile Met Glu Ser Lys Phe Arg Glu Lys Leu 
    130                 135                 140                 


Glu Pro Lys Ile Arg Glu Lys Ser Ile His Leu Arg Thr Phe Thr Phe 
145                 150                 155                 160 


Thr Lys Leu Tyr Phe Gly Gln Lys Cys Pro Arg Val Asn Gly Val Lys 
                165                 170                 175     


Ala His Thr Asn Thr Cys Asn Arg Arg Arg Val Thr Val Asp Leu Gln 
            180                 185                 190         


Ile Cys Tyr Ile Gly Asp Cys Glu Ile Ser Val Glu Leu Gln Lys Ile 
        195                 200                 205             


Gln Ala Gly Val Asn Gly Ile Gln Leu Gln Gly Thr Leu Arg Val Ile 
    210                 215                 220                 


Leu Glu Pro Leu Leu Val Asp Lys Pro Phe Val Gly Ala Val Thr Val 
225                 230                 235                 240 


Phe Phe Leu Gln Lys Pro His Leu Gln Ile Asn Trp Thr Gly Leu Thr 
                245                 250                 255     


Asn Leu Leu Asp Ala Pro Gly Ile Asn Asp Val Ser Asp Ser Leu Leu 
            260                 265                 270         


Glu Asp Leu Ile Ala Thr His Leu Val Leu Pro Asn Arg Val Thr Val 
        275                 280                 285             


Pro Val Lys Lys Gly Leu Asp Leu Thr Asn Leu Arg Phe Pro Leu Pro 
    290                 295                 300                 


Cys Gly Val Ile Arg Val His Leu Leu Glu Ala Glu Gln Leu Ala Gln 
305                 310                 315                 320 


Lys Asp Asn Phe Leu Gly Leu Arg Gly Lys Ser Asp Pro Tyr Ala Lys 
                325                 330                 335     


Val Ser Ile Gly Leu Gln His Phe Arg Ser Arg Thr Ile Tyr Arg Asn 
            340                 345                 350         


Leu Asn Pro Thr Trp Asn Glu Val Phe Glu Phe Met Val Tyr Glu Val 
        355                 360                 365             


Pro Gly Gln Asp Leu Glu Val Asp Leu Tyr Asp Glu Asp Thr Asp Arg 
    370                 375                 380                 


Asp Asp Phe Leu Gly Ser Leu Gln Ile Cys Leu Gly Asp Val Met Thr 
385                 390                 395                 400 


Asn Arg Val Val Asp Glu Trp Phe Val Leu Asn Asp Thr Thr Ser Gly 
                405                 410                 415     


Arg Leu His Leu Arg Leu Glu Trp Leu Ser Leu Leu Thr Asp Gln Glu 
            420                 425                 430         


Val Leu Thr Glu Asp His Gly Gly Leu Ser Thr Ala Ile Leu Val Val 
        435                 440                 445             


Phe Leu Glu Ser Ala Cys Asn Leu Pro Arg Asn Pro Phe Asp Tyr Leu 
    450                 455                 460                 


Asn Gly Glu Tyr Arg Ala Lys Lys Leu Ser Arg Phe Ala Arg Asn Lys 
465                 470                 475                 480 


Val Ser Lys Asp Pro Ser Ser Tyr Val Lys Leu Ser Val Gly Lys Lys 
                485                 490                 495     


Thr His Thr Ser Lys Thr Cys Pro His Asn Lys Asp Pro Val Trp Ser 
            500                 505                 510         


Gln Val Phe Ser Phe Phe Val His Asn Val Ala Thr Glu Arg Leu His 
        515                 520                 525             


Leu Lys Val Leu Asp Asp Asp Gln Glu Cys Ala Leu Gly Met Leu Glu 
    530                 535                 540                 


Val Pro Leu Cys Gln Ile Leu Pro Tyr Ala Asp Leu Thr Leu Glu Gln 
545                 550                 555                 560 


Arg Phe Gln Leu Asp His Ser Gly Leu Asp Ser Leu Ile Ser Met Arg 
                565                 570                 575     


Leu Val Leu Arg Phe Leu Gln Val Glu Glu Arg Glu Leu Gly Ser Pro 
            580                 585                 590         


Tyr Thr Gly Pro Glu Ala Leu Lys Lys Gly Pro Leu Leu Ile Lys Lys 
        595                 600                 605             


Val Ala Thr Asn Gln Gly Pro Lys Ala Gln Pro Gln Glu Glu Gly Pro 
    610                 615                 620                 


Thr Asp Leu Pro Cys Pro Pro Asp Pro Ala Ser Asp Thr Lys Asp Val 
625                 630                 635                 640 


Ser Arg Ser Thr Thr Thr Thr Thr Ser Ala Thr Thr Val Ala Thr Glu 
                645                 650                 655     


Pro Thr Ser Gln Glu Thr Gly Pro Glu Pro Lys Gly Lys Asp Ser Ala 
            660                 665                 670         


Lys Arg Phe Cys Glu Pro Ile Gly Glu Lys Lys Ser Pro Ala Thr Ile 
        675                 680                 685             


Phe Leu Thr Val Pro Gly Pro His Ser Pro Gly Pro Ile Lys Ser Pro 
    690                 695                 700                 


Arg Pro Met Lys Cys Pro Ala Ser Pro Phe Ala Trp Pro Pro Lys Arg 
705                 710                 715                 720 


Leu Ala Pro Ser Met Ser Ser Leu Asn Ser Leu Ala Ser Ser Cys Phe 
                725                 730                 735     


Asp Leu Ala Asp Ile Ser Leu Asn Ile Glu Gly Gly Asp Leu Arg Arg 
            740                 745                 750         


Arg Gln Leu Gly Glu Ile Gln Leu Thr Val Arg Tyr Val Cys Leu Arg 
        755                 760                 765             


Arg Cys Leu Ser Val Leu Ile Asn Gly Cys Arg Asn Leu Thr Pro Cys 
    770                 775                 780                 


Thr Ser Ser Gly Ala Asp Pro Tyr Val Arg Val Tyr Leu Leu Pro Glu 
785                 790                 795                 800 


Arg Lys Trp Ala Cys Arg Lys Lys Thr Ser Val Lys Arg Lys Thr Leu 
                805                 810                 815     


Glu Pro Leu Phe Asp Glu Thr Phe Glu Phe Phe Val Pro Met Glu Glu 
            820                 825                 830         


Val Lys Lys Arg Ser Leu Asp Val Ala Val Lys Asn Ser Arg Pro Leu 
        835                 840                 845             


Gly Ser His Arg Arg Lys Glu Leu Gly Lys Val Leu Ile Asp Leu Ser 
    850                 855                 860                 


Lys Glu Asp Leu Ile Lys Gly Phe Ser Gln Trp Tyr Glu Leu Thr Pro 
865                 870                 875                 880 


Asn Gly Gln Pro Arg Ser 
                885     


<210>  5270
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  5270

Met Gln Pro Pro Pro Pro Gly Pro Leu Gly Asp Cys Leu Arg Asp Trp 
1               5                   10                  15      


Glu Asp Leu Gln Gln Asp Phe Gln Asn Ile Gln Glu Thr His Arg Leu 
            20                  25                  30          


Tyr Arg Leu Lys Leu Glu Glu Leu Thr Lys Leu Gln Asn Asn Cys Thr 
        35                  40                  45              


Ser Ser Ile Thr Arg Gln Lys Lys Arg Leu Gln Glu Leu Ala Leu Ala 
    50                  55                  60                  


Leu Lys Lys Cys Lys Pro Ser Leu Pro Ala Glu Ala Glu Gly Ala Ala 
65                  70                  75                  80  


Gln Glu Leu Glu Asn Gln Met Lys Glu Arg Gln Gly Leu Phe Phe Asp 
                85                  90                  95      


Met Glu Ala Tyr Leu Pro Lys Lys Asn Gly Leu Tyr Leu Ser Leu Val 
            100                 105                 110         


Leu Gly Asn Val Asn Val Thr Leu Leu Ser Lys Gln Ala Lys Phe Ala 
        115                 120                 125             


Tyr Lys Asp Glu Tyr Glu Lys Phe Lys Leu Tyr Leu Thr Ile Ile Leu 
    130                 135                 140                 


Ile Leu Ile Ser Phe Thr Cys Arg Phe Leu Leu Asn Ser Arg Val Thr 
145                 150                 155                 160 


Asp Ala Ala Phe Asn Phe Leu Leu Val Trp Tyr Tyr Cys Thr Leu Thr 
                165                 170                 175     


Ile Arg Glu Ser Ile Leu Ile Asn Asn Gly Ser Arg Ile Lys Gly Trp 
            180                 185                 190         


Trp Val Phe His His Tyr Val Ser Thr Phe Leu Ser Gly Val Met Leu 
        195                 200                 205             


Thr Trp Pro Asp Gly Leu Met Tyr Gln Lys Phe Arg Asn Gln Phe Leu 
    210                 215                 220                 


Ser Phe Ser Met Tyr Gln Ser Phe Val Gln Phe Leu Gln Tyr Tyr Tyr 
225                 230                 235                 240 


Gln Ser Gly Cys Leu Tyr Arg Leu Arg Ala Leu Gly Glu Arg His Thr 
                245                 250                 255     


Met Asp Leu Thr Val Glu Gly Phe Gln Ser Trp Met Trp Arg Gly Leu 
            260                 265                 270         


Thr Phe Leu Leu Pro Phe Leu Phe Phe Gly His Phe Trp Gln Leu Phe 
        275                 280                 285             


Asn Ala Leu Thr Leu Phe Asn Leu Ala Gln Asp Pro Gln Cys Lys Glu 
    290                 295                 300                 


Trp Gln Val Leu Met Cys Gly Phe Pro Phe Leu Leu Leu Phe Leu Gly 
305                 310                 315                 320 


Asn Phe Phe Thr Thr Leu Arg Val Val His His Lys Phe His Ser Gln 
                325                 330                 335     


Arg His Gly Ser Lys Lys Asp 
            340             


<210>  5271
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  5271

Met Glu Ser Ser Pro Ile Pro Gln Ser Ser Gly Asn Ser Ser Thr Leu 
1               5                   10                  15      


Gly Arg Val Pro Gln Thr Pro Gly Pro Ser Thr Ala Ser Gly Val Pro 
            20                  25                  30          


Glu Val Gly Leu Arg Asp Val Ala Ser Glu Ser Val Ala Leu Phe Phe 
        35                  40                  45              


Met Leu Leu Leu Asp Leu Thr Ala Val Ala Gly Asn Ala Ala Val Met 
    50                  55                  60                  


Ala Val Ile Ala Lys Thr Pro Ala Leu Arg Lys Phe Val Phe Val Phe 
65                  70                  75                  80  


His Leu Cys Leu Val Asp Leu Leu Ala Ala Leu Thr Leu Met Pro Leu 
                85                  90                  95      


Ala Met Leu Ser Ser Ser Ala Leu Phe Asp His Ala Leu Phe Gly Glu 
            100                 105                 110         


Val Ala Cys Arg Leu Tyr Leu Phe Leu Ser Val Cys Phe Val Ser Leu 
        115                 120                 125             


Ala Ile Leu Ser Val Ser Ala Ile Asn Val Glu Arg Tyr Tyr Tyr Val 
    130                 135                 140                 


Val His Pro Met Arg Tyr Glu Val Arg Met Thr Leu Gly Leu Val Ala 
145                 150                 155                 160 


Ser Val Leu Val Gly Val Trp Val Lys Ala Leu Ala Met Ala Ser Val 
                165                 170                 175     


Pro Val Leu Gly Arg Val Ser Trp Glu Glu Gly Ala Pro Ser Val Pro 
            180                 185                 190         


Pro Gly Cys Ser Leu Gln Trp Ser His Ser Ala Tyr Cys Gln Leu Phe 
        195                 200                 205             


Val Val Val Phe Ala Val Leu Tyr Phe Leu Leu Pro Leu Leu Leu Ile 
    210                 215                 220                 


Leu Val Val Tyr Cys Ser Met Phe Arg Val Ala Arg Val Ala Ala Met 
225                 230                 235                 240 


Gln His Gly Pro Leu Pro Thr Trp Met Glu Thr Pro Arg Gln Arg Ser 
                245                 250                 255     


Glu Ser Leu Ser Ser Arg Ser Thr Met Val Thr Ser Ser Gly Ala Pro 
            260                 265                 270         


Gln Thr Thr Pro His Arg Thr Phe Gly Gly Gly Lys Ala Ala Val Val 
        275                 280                 285             


Leu Leu Ala Val Gly Gly Gln Phe Leu Leu Cys Trp Leu Pro Tyr Phe 
    290                 295                 300                 


Ser Phe His Leu Tyr Val Ala Leu Ser Ala Gln Pro Ile Ser Thr Gly 
305                 310                 315                 320 


Gln Val Glu Ser Val Val Thr Trp Ile Gly Tyr Phe Cys Phe Thr Ser 
                325                 330                 335     


Asn Pro Phe Phe Tyr Gly Cys Leu Asn Arg Gln Ile Arg Gly Glu Leu 
            340                 345                 350         


Ser Lys Gln Phe Val Cys Phe Phe Lys Pro Ala Pro Glu Glu Glu Leu 
        355                 360                 365             


Arg Leu Pro Ser Arg Glu Gly Ser Ile Glu Glu Asn Phe Leu Gln Phe 
    370                 375                 380                 


Leu Gln Gly Thr Gly Cys Pro Ser Glu Ser Trp Val Ser Arg Pro Leu 
385                 390                 395                 400 


Pro Ser Pro Lys Gln Glu Pro Pro Ala Val Asp Phe Arg Ile Pro Gly 
                405                 410                 415     


Gln Ile Ala Glu Glu Thr Ser Glu Phe Leu Glu Gln Gln Leu Thr Ser 
            420                 425                 430         


Asp Ile Ile Met Ser Asp Ser Tyr Leu Arg Pro Ala Ala Ser Pro Arg 
        435                 440                 445             


Leu Glu Ser 
    450     


<210>  5272
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  5272

Met Lys Lys Cys Leu Leu Pro Val Leu Ile Thr Cys Met Gln Thr Ala 
1               5                   10                  15      


Ile Cys Lys Asp Arg Met Met Met Ile Met Ile Leu Leu Val Asn Tyr 
            20                  25                  30          


Arg Pro Asp Glu Phe Ile Glu Cys Glu Asp Pro Val Asp His Val Gly 
        35                  40                  45              


Asn Ala Thr Ala Ser Gln Glu Leu Gly Tyr Gly Cys Leu Lys Phe Gly 
    50                  55                  60                  


Gly Gln Ala Tyr Ser Asp Val Glu His Thr Ser Val Gln Cys His Ala 
65                  70                  75                  80  


Leu Asp Gly Ile Glu Cys Ala Ser Pro Arg Thr Phe Leu Arg Glu Asn 
                85                  90                  95      


Lys Pro Cys Ile Lys Tyr Thr Gly His Tyr Phe Ile Thr Thr Leu Leu 
            100                 105                 110         


Tyr Ser Phe Phe Leu Gly Cys Phe Gly Val Asp Arg Phe Cys Leu Gly 
        115                 120                 125             


His Thr Gly Thr Ala Val Gly Lys Leu Leu Thr Leu Gly Gly Leu Gly 
    130                 135                 140                 


Ile Trp Trp Phe Val Asp Leu Ile Leu Leu Ile Thr Gly Gly Leu Met 
145                 150                 155                 160 


Pro Ser Asp Gly Ser Asn Trp Cys Thr Val Tyr 
                165                 170     


<210>  5273
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  5273

Met Glu Glu Gly Glu Arg Ser Pro Leu Leu Ser Gln Glu Thr Ala Gly 
1               5                   10                  15      


Gln Lys Pro Leu Ser Val His Arg Pro Pro Thr Ser Gly Cys Leu Gly 
            20                  25                  30          


Pro Val Pro Arg Glu Asp Gln Ala Glu Ala Trp Gly Cys Ser Cys Cys 
        35                  40                  45              


Pro Pro Glu Thr Lys His Gln Ala Leu Ser Gly Thr Pro Lys Lys Gly 
    50                  55                  60                  


Pro Ala Pro Ser Leu Ser Pro Gly Ser Ser Cys Val Lys Tyr Leu Ile 
65                  70                  75                  80  


Phe Leu Ser Asn Phe Pro Phe Ser Leu Leu Gly Leu Leu Ala Leu Ala 
                85                  90                  95      


Ile Gly Leu Trp Gly Leu Ala Val Lys Gly Ser Leu Gly Ser Asp Leu 
            100                 105                 110         


Gly Gly Pro Leu Pro Ala Asp Pro Met Leu Gly Leu Ala Leu Gly Gly 
        115                 120                 125             


Leu Val Val Ser Ala Val Ser Leu Ala Gly Tyr Leu Gly Ala Leu Cys 
    130                 135                 140                 


Glu Asn Thr Cys Leu Leu Arg Gly Phe Ser Gly Gly Ile Leu Ala Phe 
145                 150                 155                 160 


Leu Val Leu Glu Ala Val Ala Gly Ala Leu Val Val Ala Leu Trp Gly 
                165                 170                 175     


Pro Leu Gln Asp Ser Leu Glu His Thr Leu Arg Val Ala Ile Ala His 
            180                 185                 190         


Tyr Gln Asp Asp Pro Asp Leu Arg Phe Leu Leu Asp Gln Val Gln Leu 
        195                 200                 205             


Gly Leu Arg Cys Cys Gly Ala Ala Ser Tyr Gln Asp Trp Gln Gln Asn 
    210                 215                 220                 


Leu Tyr Phe Asn Cys Ser Ser Pro Gly Val Gln Ala Cys Ser Leu Pro 
225                 230                 235                 240 


Ala Ser Cys Cys Ile Asp Pro Arg Glu Asp Gly Ala Ser Val Asn Asp 
                245                 250                 255     


Gln Cys Gly Phe Gly Val Leu Arg Leu Asp Ala Asp Ala Ala Gln Arg 
            260                 265                 270         


Val Val Tyr Leu Glu Gly Cys Gly Pro Pro Leu Arg Arg Trp Leu Arg 
        275                 280                 285             


Ala Asn Leu Ala Ala Ser Gly Gly Tyr Ala Ile Ala Val Val Leu Leu 
    290                 295                 300                 


Gln Gly Ala Glu Leu Leu Leu Ala Ala Arg Leu Leu Gly Ala Leu Ala 
305                 310                 315                 320 


Ala Arg Arg Gly Ala Ala Tyr Gly Pro Gly Ala Arg Gly Glu Asp Arg 
                325                 330                 335     


Ala Gly Pro Gln Ser Pro Ser Pro Gly Ala Pro Pro Ala Ala Lys Pro 
            340                 345                 350         


Ala Arg Gly 
        355 


<210>  5274
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  5274

Met Lys Ser Gly Pro Gly Ile Gln Ala Ala Ile Asp Leu Thr Ala Gly 
1               5                   10                  15      


Ala Ala Gly Gly Thr Ala Cys Val Leu Thr Gly Gln Pro Phe Asp Thr 
            20                  25                  30          


Ile Lys Val Lys Met Gln Thr Phe Pro Asp Leu Tyr Lys Gly Leu Thr 
        35                  40                  45              


Asp Cys Phe Leu Lys Thr Tyr Ala Gln Val Gly Leu Arg Gly Phe Tyr 
    50                  55                  60                  


Lys Gly Thr Gly Pro Ala Leu Met Ala Tyr Val Ala Glu Asn Ser Val 
65                  70                  75                  80  


Leu Phe Met Cys Tyr Gly Phe Cys Gln Gln Phe Val Arg Lys Val Ala 
                85                  90                  95      


Gly Met Asp Lys Gln Ala Lys Leu Ser Asp Leu Gln Thr Ala Ala Ala 
            100                 105                 110         


Gly Ser Phe Ala Ser Ala Phe Ala Ala Leu Ala Leu Cys Pro Thr Glu 
        115                 120                 125             


Leu Val Lys Cys Arg Leu Gln Thr Met Tyr Glu Met Glu Met Ser Gly 
    130                 135                 140                 


Lys Ile Ala Lys Ser His Asn Thr Ile Trp Ser Val Val Lys Gly Ile 
145                 150                 155                 160 


Leu Lys Lys Asp Gly Pro Leu Gly Phe Tyr His Gly Leu Ser Ser Thr 
                165                 170                 175     


Leu Leu Gln Glu Val Pro Gly Tyr Phe Phe Phe Phe Gly Gly Tyr Glu 
            180                 185                 190         


Leu Ser Arg Ser Phe Phe Ala Ser Gly Arg Ser Lys Asp Glu Leu Gly 
        195                 200                 205             


Pro Val His Leu Met Leu Ser Gly Gly Val Ala Gly Ile Cys Leu Trp 
    210                 215                 220                 


Leu Val Val Phe Pro Val Asp Cys Ile Lys Ser Arg Ile Gln Val Leu 
225                 230                 235                 240 


Ser Met Tyr Gly Lys Gln Ala Gly Phe Ile Gly Thr Leu Leu Ser Val 
                245                 250                 255     


Val Arg Asn Glu Gly Ile Val Ala Leu Tyr Ser Gly Leu Lys Ala Thr 
            260                 265                 270         


Met Ile Arg Ala Ile Pro Ala Asn Gly Ala Leu Phe Val Ala Tyr Glu 
        275                 280                 285             


Tyr Ser Arg Lys Met Met Met Lys Gln Leu Glu Ala Tyr 
    290                 295                 300     


<210>  5275
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  5275

Met Pro Ile Lys Pro Val Gly Trp Ile Cys Gly Gln Val Leu Lys Asn 
1               5                   10                  15      


Phe Ser Gly Arg Ile Glu Gly Ile Gln Lys Ala Ile Met Asp Leu Val 
            20                  25                  30          


Asp Glu Phe Lys Asp Glu Phe Pro Thr Ile Leu Arg Leu Ser Gln Ser 
        35                  40                  45              


Asn Gln Lys Arg Glu Pro Ala Gln Lys Thr Ser Lys Ile Arg Met Ala 
    50                  55                  60                  


Ile Ala Leu Ala Lys Ile Asn Arg Ala Thr Leu Ile Arg Gly Leu Asn 
65                  70                  75                  80  


Ser Ile Ser Arg Ser Ser Lys Ser Val Ala Lys Leu Leu His Pro Gln 
                85                  90                  95      


Leu Ala Cys Arg Leu Leu Glu Leu Arg Asp Ile Ser Gly Arg Leu Leu 
            100                 105                 110         


Arg Glu Val Asn Ala Pro Arg Gln Pro Leu Tyr Asn Ile Gln Val Arg 
        115                 120                 125             


Lys Gly Ser Leu Phe Glu Ile Ile Ser Phe Pro Ala Lys Thr Ala Leu 
    130                 135                 140                 


Thr Ser Ile Ile Tyr Ala Ser Tyr Ala Ala Leu Ile Tyr Leu Ala Val 
145                 150                 155                 160 


Cys Val Asn Ala Val Leu Lys Lys Val Lys Asn Ile Phe Gln Glu Glu 
                165                 170                 175     


Glu Ser Ile Arg Gln Asn Arg Glu Glu Ser Glu Asn Cys Arg Lys Ala 
            180                 185                 190         


Phe Ser Glu Pro Val Leu Ser Glu Pro Met Phe Ala Glu Gly Glu Ile 
        195                 200                 205             


Lys Ala Lys Pro Tyr Arg Ser Leu Pro Glu Lys Pro Asp Ile Ser Asp 
    210                 215                 220                 


Tyr Pro Lys Leu Leu Ala Asn Lys Gln Ser Asn Asn Ile Gln Val Leu 
225                 230                 235                 240 


His Ser Val Phe Asp Gln Ser Ala Glu Met Asn Glu Gln Ile 
                245                 250                 


<210>  5276
<211>  823
<212>  PRT
<213>  Homo sapiens

<400>  5276

Met Lys Ile Gln Lys Lys Leu Thr Gly Cys Ser Arg Leu Met Leu Leu 
1               5                   10                  15      


Cys Leu Ser Leu Glu Leu Leu Leu Glu Ala Gly Ala Gly Asn Ile His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Thr Asp Lys Gly Ser Phe Val Gly Asn Ile 
        35                  40                  45              


Ala Lys Asp Leu Gly Leu Gln Pro Gln Glu Leu Ala Asp Gly Gly Val 
    50                  55                  60                  


Arg Ile Val Ser Arg Gly Arg Met Pro Leu Phe Ala Leu Asn Pro Arg 
65                  70                  75                  80  


Ser Gly Ser Leu Ile Thr Ala Arg Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Ala Gln Ser Met Pro Cys Leu Val Ser Phe Asn Ile Leu Val Glu Asp 
            100                 105                 110         


Lys Met Lys Leu Phe Pro Val Glu Val Glu Ile Ile Asp Ile Asn Asp 
        115                 120                 125             


Asn Thr Pro Gln Phe Gln Leu Glu Glu Leu Glu Phe Lys Met Asn Glu 
    130                 135                 140                 


Ile Thr Thr Pro Gly Thr Arg Val Ser Leu Pro Phe Gly Gln Asp Leu 
145                 150                 155                 160 


Asp Val Gly Met Asn Ser Leu Gln Ser Tyr Gln Leu Ser Ser Asn Pro 
                165                 170                 175     


His Phe Ser Leu Asp Val Gln Gln Gly Ala Asp Gly Pro Gln His Pro 
            180                 185                 190         


Glu Met Val Leu Gln Ser Pro Leu Asp Arg Glu Glu Glu Ala Val His 
        195                 200                 205             


His Leu Ile Leu Thr Ala Ser Asp Gly Gly Glu Pro Val Arg Ser Gly 
    210                 215                 220                 


Thr Leu Arg Ile Tyr Ile Gln Val Val Asp Ala Asn Asp Asn Pro Pro 
225                 230                 235                 240 


Ala Phe Thr Gln Ala Gln Tyr His Ile Asn Val Pro Glu Asn Val Pro 
                245                 250                 255     


Leu Gly Thr Gln Leu Leu Met Val Asn Ala Thr Asp Pro Asp Glu Gly 
            260                 265                 270         


Ala Asn Gly Glu Val Thr Tyr Ser Phe His Asn Val Asp His Arg Val 
        275                 280                 285             


Ala Gln Ile Phe Arg Leu Asp Ser Tyr Thr Gly Glu Ile Ser Asn Lys 
    290                 295                 300                 


Glu Pro Leu Asp Phe Glu Glu Tyr Lys Met Tyr Ser Met Glu Val Gln 
305                 310                 315                 320 


Ala Gln Asp Gly Ala Gly Leu Met Ala Lys Val Lys Val Leu Ile Lys 
                325                 330                 335     


Val Leu Asp Val Asn Asp Asn Ala Pro Glu Val Thr Ile Thr Ser Val 
            340                 345                 350         


Thr Thr Ala Val Pro Glu Asn Phe Pro Pro Gly Thr Ile Ile Ala Leu 
        355                 360                 365             


Ile Ser Val His Asp Gln Asp Ser Gly Asp Asn Gly Tyr Thr Thr Cys 
    370                 375                 380                 


Phe Ile Pro Gly Asn Leu Pro Phe Lys Leu Glu Lys Leu Val Asp Asn 
385                 390                 395                 400 


Tyr Tyr Arg Leu Val Thr Glu Arg Thr Leu Asp Arg Glu Leu Ile Ser 
                405                 410                 415     


Gly Tyr Asn Ile Thr Ile Thr Ala Ile Asp Gln Gly Thr Pro Ala Leu 
            420                 425                 430         


Ser Thr Glu Thr His Ile Ser Leu Leu Val Thr Asp Ile Asn Asp Asn 
        435                 440                 445             


Ser Pro Val Phe His Gln Asp Ser Tyr Ser Ala Tyr Ile Pro Glu Asn 
    450                 455                 460                 


Asn Pro Arg Gly Ala Ser Ile Phe Ser Val Arg Ala His Asp Leu Asp 
465                 470                 475                 480 


Ser Asn Glu Asn Ala Gln Ile Thr Tyr Ser Leu Ile Glu Asp Thr Ile 
                485                 490                 495     


Gln Gly Ala Pro Leu Ser Ala Tyr Leu Ser Ile Asn Ser Asp Thr Gly 
            500                 505                 510         


Val Leu Tyr Ala Leu Arg Ser Phe Asp Tyr Glu Gln Phe Arg Asp Met 
        515                 520                 525             


Gln Leu Lys Val Met Ala Arg Asp Ser Gly Asp Pro Pro Leu Ser Ser 
    530                 535                 540                 


Asn Val Ser Leu Ser Leu Phe Leu Leu Asp Gln Asn Asp Asn Ala Pro 
545                 550                 555                 560 


Glu Ile Leu Tyr Pro Ala Leu Pro Thr Asp Gly Ser Thr Gly Val Glu 
                565                 570                 575     


Leu Ala Pro Leu Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val 
            580                 585                 590         


Ala Val Asp Arg Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Arg Leu 
        595                 600                 605             


Leu Lys Ala Ser Glu Pro Gly Leu Phe Ser Val Gly Leu His Thr Gly 
    610                 615                 620                 


Glu Val Arg Thr Ala Arg Ala Leu Leu Asp Arg Asp Ala Leu Lys Gln 
625                 630                 635                 640 


Ser Leu Val Val Ala Val Gln Asp His Gly Gln Pro Pro Leu Ser Ala 
                645                 650                 655     


Thr Val Thr Leu Thr Val Ala Val Ala Asp Arg Ile Ser Asp Ile Leu 
            660                 665                 670         


Ala Asp Leu Gly Ser Leu Glu Pro Ser Ala Lys Pro Asn Asp Ser Asp 
        675                 680                 685             


Leu Thr Leu Tyr Leu Val Val Ala Ala Ala Ala Val Ser Cys Val Phe 
    690                 695                 700                 


Leu Ala Phe Val Ile Val Leu Leu Ala His Arg Leu Arg Arg Trp His 
705                 710                 715                 720 


Lys Ser Arg Leu Leu Gln Ala Ser Gly Gly Gly Leu Ala Ser Met Pro 
                725                 730                 735     


Gly Ser His Phe Val Gly Val Asp Gly Val Arg Ala Phe Leu Gln Thr 
            740                 745                 750         


Tyr Ser His Glu Val Ser Leu Thr Ala Asp Ser Arg Lys Ser His Leu 
        755                 760                 765             


Ile Phe Pro Gln Pro Asn Tyr Ala Asp Thr Leu Ile Ser Gln Glu Ser 
    770                 775                 780                 


Cys Glu Lys Lys Gly Phe Leu Ser Ala Pro Gln Ser Leu Leu Glu Asp 
785                 790                 795                 800 


Lys Lys Glu Pro Phe Ser Gln Val Asn Phe Cys Asp Glu Cys Ile Ser 
                805                 810                 815     


Tyr Leu Glu Lys Asn Asn Ser 
            820             


<210>  5277
<211>  879
<212>  PRT
<213>  Homo sapiens

<400>  5277

Met Ala Asp Gly Gly Gly Pro Lys Asp Ala Pro Ser Leu Arg Ser Ser 
1               5                   10                  15      


Pro Gly Pro Ala Pro Arg Val Pro Arg Ala Val Gly Pro Ser Gly Gly 
            20                  25                  30          


Gly Gly Glu Thr Pro Arg Thr Ala Ala Leu Ala Leu Arg Phe Asp Lys 
        35                  40                  45              


Pro Ile Lys Gln Ala Phe Tyr Asn Thr Gly Ala Val Leu Phe Val Cys 
    50                  55                  60                  


Leu Cys Cys Gly Ala Ala Val Leu Val Tyr Phe Ile Leu Glu Ala Phe 
65                  70                  75                  80  


Leu Arg Pro Leu Leu Trp Ala Val Leu Cys Gly Thr Phe Leu His Pro 
                85                  90                  95      


Phe Lys Ser Ser Leu Thr Arg Leu Gly Arg His Trp Leu Gln Arg Leu 
            100                 105                 110         


His Arg Ala His Thr Pro Ile Val Leu Ala Ala Leu Leu Leu Pro Leu 
        115                 120                 125             


Cys Phe Val Asp Tyr Gly Val Glu Ala Leu Gly Glu Gln Ala Leu Arg 
    130                 135                 140                 


Arg Arg Arg Leu Leu Leu Leu Leu Gly Ala Gly Gly Pro Leu Leu Tyr 
145                 150                 155                 160 


Gly Leu Tyr Cys Leu Gly Ser Tyr Leu Gly Val Gln Val Leu Leu Val 
                165                 170                 175     


His Ala Ala Thr Leu Ile Cys Arg Gly Leu Asp Tyr Phe Ser Ser Leu 
            180                 185                 190         


Trp Ile Trp Thr Leu Val Val Gly Tyr Val Leu Thr Val Ser Phe Lys 
        195                 200                 205             


Trp Asn Ala Ser Thr Glu Arg Tyr Leu Arg Ala Val Ser Ile Pro Val 
    210                 215                 220                 


Trp Ile Ile Leu Leu Phe His Leu Ala Ser Leu Ala Gly Ser Trp Arg 
225                 230                 235                 240 


Ile Pro Val Phe Leu Val Ile Val Phe Leu Met Ser Val Gly Thr Leu 
                245                 250                 255     


Tyr Glu Lys Gln Asn Gly Lys Glu Ser Ser Gly Ala Glu Leu Pro Gly 
            260                 265                 270         


Gln Val Ile Ser Met Ala Ala Ser Thr Leu Ala Asn Leu Ala Ile Ser 
        275                 280                 285             


Ile Thr Gly Tyr Glu Ser Ser Ser Glu Asp Gln Pro Ser Thr Gln Pro 
    290                 295                 300                 


Ala Glu Ala Val Asp Arg Gly Glu Ser Ala Pro Thr Leu Ser Thr Ser 
305                 310                 315                 320 


Pro Ser Pro Ser Ser Pro Ser Pro Thr Ser Pro Ser Pro Thr Leu Gly 
                325                 330                 335     


Arg Arg Arg Pro Glu Ile Gly Thr Phe Leu Arg Lys Lys Lys Thr Ser 
            340                 345                 350         


Asp Ile Tyr Phe Val Ser Leu Val Trp Ala Ile Val Val Met Gln Ile 
        355                 360                 365             


Trp Leu Asn Leu Trp Ile Val Gln Leu Leu Pro Val Pro Ile Ala Val 
    370                 375                 380                 


Trp Ile Leu Lys Lys Leu Val Ile His Phe Gly Val Val Asp Phe Leu 
385                 390                 395                 400 


Glu Lys Arg Tyr His Val Trp Trp Gly Ile Ile Glu Ser Phe Leu Lys 
                405                 410                 415     


Glu Arg Gln Gly Ala Leu Ala Pro Trp Pro Ile Val Gly Leu Gly Lys 
            420                 425                 430         


Phe Leu Leu Lys Val Asp Ser Lys Leu Trp His Trp Leu Asn Lys Lys 
        435                 440                 445             


Met Ile Ile Trp Leu Glu Lys Met Leu Asp Lys Ile Ile Ser Ile Phe 
    450                 455                 460                 


Ile Ile Phe Leu Leu Val Ile Gly Thr Leu Leu Leu Ala Leu Leu Leu 
465                 470                 475                 480 


Thr Ala Lys Val His Gln Glu Ser Val His Met Ile Glu Val Thr Ser 
                485                 490                 495     


Asn Leu Ile Asn Glu Thr Leu Ala Asn His Pro Glu Trp Ala Asn Trp 
            500                 505                 510         


Leu Pro Glu Ala Gln Val Val Gln Arg Ala Leu Asn Ser Ala Ala Asn 
        515                 520                 525             


Asn Val Tyr Gln Tyr Gly Arg Glu Trp Ile Thr His Lys Leu His Lys 
    530                 535                 540                 


Ile Leu Gly Asp Lys Val Asn Asn Thr Ala Val Ile Glu Lys Gln Val 
545                 550                 555                 560 


Leu Glu Leu Trp Asp Arg Leu Tyr His Ser Trp Phe Val Lys Asn Val 
                565                 570                 575     


Thr His Ser Gly Arg His Lys Gly Gln Lys Leu His Val Ser Arg Gln 
            580                 585                 590         


Asn Ser Trp Leu Gly Asp Ile Leu Asp Trp Gln Asp Ile Val Ser Phe 
        595                 600                 605             


Val His Glu Asn Ile Glu Thr Phe Leu Ser Ile Leu Glu Ser Leu Trp 
    610                 615                 620                 


Ile Val Met Ser Arg Asn Val Ser Leu Leu Phe Thr Thr Val Thr Thr 
625                 630                 635                 640 


Leu Leu Thr Ile Leu Phe Tyr Ser Gly Thr Ala Leu Leu Asn Phe Val 
                645                 650                 655     


Leu Ser Leu Ile Ile Phe Leu Thr Thr Leu Phe Tyr Leu Leu Ser Ser 
            660                 665                 670         


Ser Asp Glu Tyr Tyr Lys Pro Val Lys Trp Val Ile Ser Leu Thr Pro 
        675                 680                 685             


Leu Ser Gln Pro Gly Pro Ser Ser Asn Ile Ile Gly Gln Ser Val Glu 
    690                 695                 700                 


Glu Ala Ile Arg Gly Val Phe Asp Ala Ser Leu Lys Met Ala Gly Phe 
705                 710                 715                 720 


Tyr Gly Leu Tyr Thr Trp Leu Thr His Thr Met Phe Gly Ile Asn Ile 
                725                 730                 735     


Val Phe Ile Pro Ser Ala Leu Ala Ala Ile Leu Gly Ala Val Pro Phe 
            740                 745                 750         


Leu Gly Thr Tyr Trp Ala Ala Val Pro Ala Val Leu Asp Leu Trp Leu 
        755                 760                 765             


Thr Gln Gly Leu Gly Cys Lys Ala Ile Leu Leu Leu Ile Phe His Leu 
    770                 775                 780                 


Leu Pro Thr Tyr Phe Val Asp Thr Ala Ile Tyr Ser Asp Ile Ser Gly 
785                 790                 795                 800 


Gly Gly His Pro Tyr Leu Thr Gly Leu Ala Val Ala Gly Gly Ala Tyr 
                805                 810                 815     


Tyr Leu Gly Leu Glu Gly Ala Ile Ile Gly Pro Ile Leu Leu Cys Ile 
            820                 825                 830         


Leu Val Val Ala Ser Asn Ile Tyr Ser Ala Met Leu Val Ser Pro Thr 
        835                 840                 845             


Asn Ser Val Pro Thr Pro Asn Gln Thr Pro Trp Pro Ala Gln Pro Gln 
    850                 855                 860                 


Arg Thr Phe Arg Asp Ile Ser Glu Asp Leu Lys Ser Ser Val Gly 
865                 870                 875                 


<210>  5278
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  5278

Met Glu Ala Val Tyr Leu Val Val Asn Gly Leu Gly Leu Val Leu Asp 
1               5                   10                  15      


Val Leu Thr Leu Val Leu Asp Leu Asn Phe Leu Leu Val Ser Ser Leu 
            20                  25                  30          


Leu Ala Ser Leu Ala Trp Leu Leu Ala Phe Val Tyr Asn Leu Pro His 
        35                  40                  45              


Thr Val Leu Thr Ser Leu Leu His Leu Gly Arg Gly Val Leu Leu Ser 
    50                  55                  60                  


Leu Leu Ala Leu Ile Glu Ala Val Val Arg Phe Thr Cys Gly Gly Leu 
65                  70                  75                  80  


Gln Ala Leu Cys Thr Leu Leu Tyr Ser Cys Cys Ser Gly Leu Glu Ser 
                85                  90                  95      


Leu Lys Leu Leu Gly His Leu Ala Ser His Gly Ala Leu Arg Ser Arg 
            100                 105                 110         


Glu Ile Leu His Arg Gly Val Leu Asn Val Val Ser Ser Gly His Ala 
        115                 120                 125             


Leu Leu Arg Gln Ala Cys Asp Ile Cys Ala Ile Ala Met Ser Leu Val 
    130                 135                 140                 


Ala Tyr Val Ile Asn Ser Leu Val Asn Ile Cys Leu Ile Gly Thr Gln 
145                 150                 155                 160 


Asn Leu Phe Ser Leu Val Leu Ala Leu Trp Asp Ala Val Thr Gly Pro 
                165                 170                 175     


Leu Trp Arg Met Thr Asp Val Val Ala Ala Phe Leu Ala His Ile Ser 
            180                 185                 190         


Ser Ser Ala Val Ala Met Ala Ile Leu Leu Trp Thr Pro Cys Gln Leu 
        195                 200                 205             


Ala Leu Glu Leu Leu Ala Ser Ala Ala Arg Leu Leu Ala Ser Phe Val 
    210                 215                 220                 


Leu Val Asn Leu Thr Gly Leu Val Leu Leu Ala Cys Val Leu Ala Val 
225                 230                 235                 240 


Thr Val Thr Val Leu His Pro Asp Phe Thr Leu Arg Leu Ala Thr Gln 
                245                 250                 255     


Ala Leu Ser Gln Leu His Ala Arg Pro Ser Tyr His Arg Leu Arg Glu 
            260                 265                 270         


Asp Val Met Arg Leu Ser Arg Leu Ala Leu Gly Ser Glu Ala Trp Arg 
        275                 280                 285             


Arg Val Trp Ser Arg Ser Leu Gln Leu Ala Ser Trp Pro Asn Arg Gly 
    290                 295                 300                 


Gly Ala Pro Gly Ala Pro Gln Gly Asp Pro Met Arg Val Phe Ser Val 
305                 310                 315                 320 


Arg Thr Arg Arg Gln Asp Thr Leu Pro Glu Ala Gly Arg Arg Ser Glu 
                325                 330                 335     


Ala Glu Glu Glu Glu Ala Arg Thr Ile Arg Val Thr Pro Val Arg Gly 
            340                 345                 350         


Arg Glu Arg Leu Asn Glu Glu Glu Pro Pro Gly Gly Gln Asp Pro Trp 
        355                 360                 365             


Lys Leu Leu Lys Glu Gln Glu Glu Arg Lys Lys Cys Val Ile Cys Gln 
    370                 375                 380                 


Asp Gln Ser Lys Thr Val Leu Leu Leu Pro Cys Arg His Leu Cys Leu 
385                 390                 395                 400 


Cys Gln Ala Cys Thr Glu Ile Leu Met Arg His Pro Val Tyr His Arg 
                405                 410                 415     


Asn Cys Pro Leu Cys Arg Arg Gly Ile Leu Gln Thr Leu Asn Val Tyr 
            420                 425                 430         


Leu 
    


<210>  5279
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  5279

Met Asn His Leu Pro Glu Asp Met Glu Asn Ala Leu Thr Gly Ser Gln 
1               5                   10                  15      


Ser Ser His Ala Ser Leu Arg Asn Ile His Ser Ile Asn Pro Thr Gln 
            20                  25                  30          


Leu Met Ala Arg Ile Glu Ser Tyr Glu Gly Arg Glu Lys Lys Gly Ile 
        35                  40                  45              


Ser Asp Val Arg Arg Thr Phe Cys Leu Phe Val Thr Phe Asp Leu Leu 
    50                  55                  60                  


Phe Val Thr Leu Leu Trp Ile Ile Glu Leu Asn Val Asn Gly Gly Ile 
65                  70                  75                  80  


Glu Asn Thr Leu Glu Lys Glu Val Met Gln Tyr Asp Tyr Tyr Ser Ser 
                85                  90                  95      


Tyr Phe Asp Ile Phe Leu Leu Ala Val Phe Arg Phe Lys Val Leu Ile 
            100                 105                 110         


Leu Ala Tyr Ala Val Cys Arg Leu Arg His Trp Trp Ala Ile Ala Leu 
        115                 120                 125             


Thr Thr Ala Val Thr Ser Ala Phe Leu Leu Ala Lys Val Ile Leu Ser 
    130                 135                 140                 


Lys Leu Phe Ser Gln Gly Ala Phe Gly Tyr Val Leu Pro Ile Ile Ser 
145                 150                 155                 160 


Phe Ile Leu Ala Trp Ile Glu Thr Trp Phe Leu Asp Phe Lys Val Leu 
                165                 170                 175     


Pro Gln Glu Ala Glu Glu Glu Asn Arg Leu Leu Ile Val Gln Asp Ala 
            180                 185                 190         


Ser Glu Arg Ala Ala Leu Ile Pro Gly Gly Leu Ser Asp Gly Gln Phe 
        195                 200                 205             


Tyr Ser Pro Pro Glu Ser Glu Ala Gly Ser Glu Glu Ala Glu Glu Lys 
    210                 215                 220                 


Gln Asp Ser Glu Lys Pro Leu Leu Glu Leu 
225                 230                 


<210>  5280
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  5280

Met Thr Ser His His Cys Val Gly Pro Gly Asn His Ile Ser Trp Ser 
1               5                   10                  15      


Gly His Glu Lys Glu His Arg Leu Asp Tyr Cys Pro Glu Val Thr Phe 
            20                  25                  30          


Pro Leu Thr Lys Gly Phe Pro Leu Gly Tyr Thr Leu Leu Phe Asn Phe 
        35                  40                  45              


Ala Ser Tyr Pro Phe Leu Leu Pro Ser Lys Ile Lys Thr Leu Leu Arg 
    50                  55                  60                  


Asn Lys Asp Ser Phe Leu Asn Ile Leu Cys Pro Ala Cys Leu Leu Leu 
65                  70                  75                  80  


Ile Arg Arg Cys Asn Ile Glu Tyr Ser Ser Thr Gly Leu Asn Phe Leu 
                85                  90                  95      


Asn Thr Phe Thr Val Ser Leu Ile Val Thr Val Ile Pro Leu Leu Gln 
            100                 105                 110         


Asn Val Pro Val Pro Leu Gly Asn Asn Val Gly Lys Met Gln Val Tyr 
        115                 120                 125             


Glu 
    


<210>  5281
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  5281

Met Ala Ala Ala Trp Pro Ser Gly Pro Ser Ala Pro Glu Ala Val Thr 
1               5                   10                  15      


Ala Arg Leu Val Gly Val Leu Trp Phe Val Ser Val Thr Thr Gly Pro 
            20                  25                  30          


Trp Gly Ala Val Ala Thr Ser Ala Gly Gly Glu Glu Ser Leu Lys Cys 
        35                  40                  45              


Glu Asp Leu Lys Val Gly Gln Tyr Ile Cys Lys Asp Pro Lys Ile Asn 
    50                  55                  60                  


Asp Ala Thr Gln Glu Pro Val Asn Cys Thr Asn Tyr Thr Ala His Val 
65                  70                  75                  80  


Ser Cys Phe Pro Ala Pro Asn Ile Thr Cys Lys Asp Ser Ser Gly Asn 
                85                  90                  95      


Glu Thr His Phe Thr Gly Asn Glu Val Gly Phe Phe Lys Pro Ile Ser 
            100                 105                 110         


Cys Arg Asn Val Asn Gly Tyr Ser Tyr Lys Val Ala Val Ala Leu Ser 
        115                 120                 125             


Leu Phe Leu Gly Trp Leu Gly Ala Asp Arg Phe Tyr Leu Gly Tyr Pro 
    130                 135                 140                 


Ala Leu Gly Leu Leu Lys Phe Cys Thr Val Gly Phe Cys Gly Ile Gly 
145                 150                 155                 160 


Ser Leu Ile Asp Phe Ile Leu Ile Ser Met Gln Ile Val Gly Pro Ser 
                165                 170                 175     


Asp Gly Ser Ser Tyr Ile Ile Asp Tyr Tyr Gly Thr Arg Leu Thr Arg 
            180                 185                 190         


Leu Ser Ile Thr Asn Glu Thr Phe Arg Lys Thr Gln Leu Tyr Pro 
        195                 200                 205         


<210>  5282
<211>  891
<212>  PRT
<213>  Homo sapiens

<400>  5282

Met Ser Gln Val Gly Gly Arg Gly Asp Arg Cys Thr Gln Glu Val Gln 
1               5                   10                  15      


Gly Leu Val His Gly Ala Gly Asp Leu Ser Ala Ser Leu Ala Glu Asn 
            20                  25                  30          


Ser Pro Thr Met Ser Gln Asn Gly Tyr Phe Glu Asp Ser Ser Tyr Tyr 
        35                  40                  45              


Lys Cys Asp Thr Asp Asp Thr Phe Glu Ala Arg Glu Glu Ile Leu Gly 
    50                  55                  60                  


Asp Glu Ala Phe Asp Thr Ala Asn Ser Ser Ile Val Ser Gly Glu Ser 
65                  70                  75                  80  


Ile Arg Phe Phe Val Asn Val Asn Leu Glu Met Gln Ala Thr Asn Thr 
                85                  90                  95      


Glu Asn Glu Ala Thr Ser Gly Gly Cys Val Leu Leu His Thr Ser Arg 
            100                 105                 110         


Lys Tyr Leu Lys Leu Lys Asn Phe Lys Glu Glu Ile Arg Ala His Arg 
        115                 120                 125             


Asp Leu Asp Gly Phe Leu Ala Gln Ala Ser Ile Val Leu Asn Glu Thr 
    130                 135                 140                 


Ala Thr Ser Leu Asp Asn Val Leu Arg Thr Met Leu Arg Arg Phe Ala 
145                 150                 155                 160 


Arg Asp Pro Asp Asn Asn Glu Pro Asn Cys Asn Leu Asp Leu Leu Met 
                165                 170                 175     


Ala Met Leu Phe Thr Asp Ala Gly Ala Pro Met Arg Gly Lys Val His 
            180                 185                 190         


Leu Leu Ser Asp Thr Ile Gln Gly Val Thr Ala Thr Val Thr Gly Val 
        195                 200                 205             


Arg Tyr Gln Gln Ser Trp Leu Cys Ile Ile Cys Thr Met Lys Ala Leu 
    210                 215                 220                 


Gln Lys Arg His Val Cys Ile Ser Arg Leu Val Arg Pro Gln Asn Trp 
225                 230                 235                 240 


Gly Glu Asn Ser Cys Glu Val Arg Phe Val Ile Leu Val Leu Ala Pro 
                245                 250                 255     


Pro Lys Met Lys Ser Thr Lys Thr Ala Met Glu Val Ala Arg Thr Phe 
            260                 265                 270         


Ala Thr Met Phe Ser Asp Ile Ala Phe Arg Gln Lys Leu Leu Glu Thr 
        275                 280                 285             


Arg Thr Glu Glu Glu Phe Lys Glu Ala Leu Val His Gln Arg Gln Leu 
    290                 295                 300                 


Leu Thr Met Val Ser His Gly Pro Val Ala Pro Arg Thr Lys Glu Arg 
305                 310                 315                 320 


Ser Thr Val Ser Leu Pro Ala His Arg His Pro Glu Pro Pro Lys Cys 
                325                 330                 335     


Lys Asp Phe Val Pro Phe Gly Lys Gly Ile Arg Glu Asp Ile Ala Arg 
            340                 345                 350         


Arg Phe Pro Leu Tyr Pro Leu Asp Phe Thr Asp Gly Ile Ile Gly Lys 
        355                 360                 365             


Asn Lys Ala Val Gly Lys Tyr Ile Thr Thr Thr Leu Phe Leu Tyr Phe 
    370                 375                 380                 


Ala Cys Leu Leu Pro Thr Ile Ala Phe Gly Ser Leu Asn Asp Glu Asn 
385                 390                 395                 400 


Thr Asp Gly Ala Ile Asp Val Gln Lys Thr Ile Ala Gly Gln Ser Ile 
                405                 410                 415     


Gly Gly Leu Leu Tyr Ala Leu Phe Ser Gly Gln Pro Leu Val Ile Leu 
            420                 425                 430         


Leu Thr Thr Ala Pro Leu Ala Leu Tyr Ile Gln Val Ile Arg Val Ile 
        435                 440                 445             


Cys Asp Asp Tyr Asp Leu Asp Phe Asn Ser Phe Tyr Ala Trp Thr Gly 
    450                 455                 460                 


Leu Trp Asn Ser Phe Phe Leu Ala Leu Tyr Ala Phe Phe Asn Leu Ser 
465                 470                 475                 480 


Leu Val Met Ser Leu Phe Lys Arg Ser Thr Glu Glu Ile Ile Ala Leu 
                485                 490                 495     


Phe Ile Ser Ile Thr Phe Val Leu Asp Ala Val Lys Gly Thr Val Lys 
            500                 505                 510         


Ile Phe Trp Lys Tyr Tyr Tyr Gly His Tyr Leu Asp Asp Tyr His Thr 
        515                 520                 525             


Lys Arg Thr Ser Ser Leu Val Ser Leu Ser Gly Leu Gly Ala Ser Leu 
    530                 535                 540                 


Asn Ala Ser Leu His Thr Ala Leu Asn Ala Ser Phe Leu Ala Ser Pro 
545                 550                 555                 560 


Thr Glu Leu Pro Ser Ala Thr His Ser Gly Gln Ala Thr Ala Val Leu 
                565                 570                 575     


Ser Leu Leu Ile Met Leu Gly Thr Leu Trp Leu Gly Tyr Thr Leu Tyr 
            580                 585                 590         


Gln Phe Lys Lys Ser Pro Tyr Leu His Pro Cys Val Arg Glu Ile Leu 
        595                 600                 605             


Ser Asp Cys Ala Leu Pro Ile Ala Val Leu Ala Phe Ser Leu Ile Ser 
    610                 615                 620                 


Ser His Gly Phe Arg Glu Ile Glu Met Ser Lys Phe Arg Tyr Asn Pro 
625                 630                 635                 640 


Ser Glu Ser Pro Phe Ala Met Ala Gln Ile Gln Ser Leu Ser Leu Arg 
                645                 650                 655     


Ala Val Ser Gly Ala Met Gly Leu Gly Phe Leu Leu Ser Met Leu Phe 
            660                 665                 670         


Phe Ile Glu Gln Asn Leu Val Ala Ala Leu Val Asn Ala Pro Glu Asn 
        675                 680                 685             


Arg Leu Val Lys Gly Thr Ala Tyr His Trp Asp Leu Leu Leu Leu Ala 
    690                 695                 700                 


Ile Ile Asn Thr Gly Leu Ser Leu Phe Gly Leu Pro Trp Ile His Ala 
705                 710                 715                 720 


Ala Tyr Pro His Ser Pro Leu His Val Arg Ala Leu Ala Leu Val Glu 
                725                 730                 735     


Glu Arg Val Glu Asn Gly His Ile Tyr Asp Thr Ile Val Asn Val Lys 
            740                 745                 750         


Glu Thr Arg Leu Thr Ser Leu Gly Ala Ser Val Leu Val Gly Leu Ser 
        755                 760                 765             


Leu Leu Leu Leu Pro Val Pro Leu Gln Trp Ile Pro Lys Pro Val Leu 
    770                 775                 780                 


Tyr Gly Leu Phe Leu Tyr Ile Ala Leu Thr Ser Leu Asp Gly Asn Gln 
785                 790                 795                 800 


Leu Val Gln Arg Val Ala Leu Leu Leu Lys Glu Gln Thr Ala Tyr Pro 
                805                 810                 815     


Pro Thr His Tyr Ile Arg Arg Val Pro Gln Arg Lys Ile His Tyr Phe 
            820                 825                 830         


Thr Gly Leu Gln Val Leu Gln Leu Leu Leu Leu Cys Ala Phe Gly Met 
        835                 840                 845             


Ser Ser Leu Pro Tyr Met Lys Met Ile Phe Pro Leu Ile Met Ile Ala 
    850                 855                 860                 


Met Ile Pro Ile Arg Tyr Ile Leu Leu Pro Arg Ile Ile Glu Ala Lys 
865                 870                 875                 880 


Tyr Leu Asp Val Met Asp Ala Glu His Arg Pro 
                885                 890     


<210>  5283
<211>  528
<212>  PRT
<213>  Homo sapiens

<400>  5283

Met Ala Gly Ser Asp Thr Ala Pro Phe Leu Ser Gln Ala Asp Asp Pro 
1               5                   10                  15      


Asp Asp Gly Pro Val Pro Gly Thr Pro Gly Leu Pro Gly Ser Thr Gly 
            20                  25                  30          


Asn Pro Lys Ser Glu Glu Pro Glu Val Pro Asp Gln Glu Gly Leu Gln 
        35                  40                  45              


Arg Ile Thr Gly Leu Ser Pro Gly Arg Ser Ala Leu Ile Val Ala Val 
    50                  55                  60                  


Leu Cys Tyr Ile Asn Leu Leu Asn Tyr Met Asp Arg Phe Thr Val Ala 
65                  70                  75                  80  


Gly Val Leu Pro Asp Ile Glu Gln Phe Phe Asn Ile Gly Asp Ser Ser 
                85                  90                  95      


Ser Gly Leu Ile Gln Thr Val Phe Ile Ser Ser Tyr Met Val Leu Ala 
            100                 105                 110         


Pro Val Phe Gly Tyr Leu Gly Asp Arg Tyr Asn Arg Lys Tyr Leu Met 
        115                 120                 125             


Cys Gly Gly Ile Ala Phe Trp Ser Leu Val Thr Leu Gly Ser Ser Phe 
    130                 135                 140                 


Ile Pro Gly Glu His Phe Trp Leu Leu Leu Leu Thr Arg Gly Leu Val 
145                 150                 155                 160 


Gly Val Gly Glu Ala Ser Tyr Ser Thr Ile Ala Pro Thr Leu Ile Ala 
                165                 170                 175     


Asp Leu Phe Val Ala Asp Gln Arg Ser Arg Met Leu Ser Ile Phe Tyr 
            180                 185                 190         


Phe Ala Ile Pro Val Gly Ser Gly Leu Gly Tyr Ile Ala Gly Ser Lys 
        195                 200                 205             


Val Lys Asp Met Ala Gly Asp Trp His Trp Ala Leu Arg Val Thr Pro 
    210                 215                 220                 


Gly Leu Gly Val Val Ala Val Leu Leu Leu Phe Leu Val Val Arg Glu 
225                 230                 235                 240 


Pro Pro Arg Gly Ala Val Glu Arg His Ser Asp Leu Pro Pro Leu Asn 
                245                 250                 255     


Pro Thr Ser Trp Trp Ala Asp Leu Arg Ala Leu Ala Arg Asn Pro Ser 
            260                 265                 270         


Phe Val Leu Ser Ser Leu Gly Phe Thr Ala Val Ala Phe Val Thr Gly 
        275                 280                 285             


Ser Leu Ala Leu Trp Ala Pro Ala Phe Leu Leu Arg Ser Arg Val Val 
    290                 295                 300                 


Leu Gly Glu Thr Pro Pro Cys Leu Pro Gly Asp Ser Cys Ser Ser Ser 
305                 310                 315                 320 


Asp Ser Leu Ile Phe Gly Leu Ile Thr Cys Leu Thr Gly Val Leu Gly 
                325                 330                 335     


Val Gly Leu Gly Val Glu Ile Ser Arg Arg Leu Arg His Ser Asn Pro 
            340                 345                 350         


Arg Ala Asp Pro Leu Val Cys Ala Thr Gly Leu Leu Gly Ser Ala Pro 
        355                 360                 365             


Phe Leu Phe Leu Ser Leu Ala Cys Ala Arg Gly Ser Ile Val Ala Thr 
    370                 375                 380                 


Tyr Ile Phe Ile Phe Ile Gly Glu Thr Leu Leu Ser Met Asn Trp Ala 
385                 390                 395                 400 


Ile Val Ala Asp Ile Leu Leu Tyr Val Val Ile Pro Thr Arg Arg Ser 
                405                 410                 415     


Thr Ala Glu Ala Phe Gln Ile Val Leu Ser His Leu Leu Gly Asp Ala 
            420                 425                 430         


Gly Ser Pro Tyr Leu Ile Gly Leu Ile Ser Asp Arg Leu Arg Arg Asn 
        435                 440                 445             


Trp Pro Pro Ser Phe Leu Ser Glu Phe Arg Ala Leu Gln Phe Ser Leu 
    450                 455                 460                 


Met Leu Cys Ala Phe Val Gly Ala Leu Gly Gly Ala Ala Phe Leu Gly 
465                 470                 475                 480 


Thr Ala Ile Phe Ile Glu Ala Asp Arg Arg Arg Ala Gln Leu His Val 
                485                 490                 495     


Gln Gly Leu Leu His Glu Ala Gly Ser Thr Asp Asp Arg Ile Val Val 
            500                 505                 510         


Pro Gln Arg Gly Arg Ser Thr Arg Val Pro Val Ala Ser Val Leu Ile 
        515                 520                 525             


<210>  5284
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  5284

Met Leu Asp His Lys Asp Leu Glu Ala Glu Ile His Pro Leu Lys Asn 
1               5                   10                  15      


Glu Glu Arg Lys Ser Gln Glu Asn Leu Gly Asn Pro Ser Lys Asn Glu 
            20                  25                  30          


Asp Asn Val Lys Ser Ala Pro Pro Gln Ser Arg Leu Ser Arg Cys Arg 
        35                  40                  45              


Ala Ala Ala Phe Phe Leu Ser Leu Phe Leu Cys Leu Phe Val Val Phe 
    50                  55                  60                  


Val Val Ser Phe Val Ile Pro Cys Pro Asp Arg Pro Ala Ser Gln Arg 
65                  70                  75                  80  


Met Trp Arg Ile Asp Tyr Ser Ala Ala Val Ile Tyr Asp Phe Leu Ala 
                85                  90                  95      


Val Asp Asp Ile Asn Gly Asp Arg Ile Gln Asp Val Leu Phe Leu Tyr 
            100                 105                 110         


Lys Asn Thr Asn Ser Ser Asn Asn Phe Ser Arg Ser Cys Val Asp Glu 
        115                 120                 125             


Gly Phe Ser Ser Pro Cys Thr Phe Ala Ala Ala Val Ser Gly Ala Asn 
    130                 135                 140                 


Gly Ser Thr Leu Trp Glu Arg Pro Val Ala Gln Asp Val Ala Leu Val 
145                 150                 155                 160 


Glu Cys Ala Val Pro Gln Pro Arg Gly Ser Glu Ala Pro Ser Ala Cys 
                165                 170                 175     


Ile Leu Val Gly Arg Pro Ser Ser Phe Ile Ala Val Asn Leu Phe Thr 
            180                 185                 190         


Gly Glu Thr Leu Trp Asn His Ser Ser Ser Phe Ser Gly Asn Ala Ser 
        195                 200                 205             


Ile Leu Ser Pro Leu Leu Gln Val Pro Asp Val Asp Gly Asp Gly Ala 
    210                 215                 220                 


Pro Asp Leu Leu Val Leu Thr Gln Glu Arg Glu Glu Val Ser Gly His 
225                 230                 235                 240 


Leu Tyr Ser Gly Ser Thr Gly His Gln Ile Gly Leu Arg Gly Ser Leu 
                245                 250                 255     


Gly Val Asp Gly Glu Ser Gly Phe Leu Leu His Val Thr Arg Thr Gly 
            260                 265                 270         


Ala His Tyr Ile Leu Phe Pro Cys Ala Ser Ser Leu Cys Gly Cys Ser 
        275                 280                 285             


Val Lys Gly Leu Tyr Glu Lys Val Thr Gly Ser Gly Gly Pro Phe Lys 
    290                 295                 300                 


Ser Asp Pro His Trp Glu Ser Met Leu Asn Ala Thr Thr Arg Arg Met 
305                 310                 315                 320 


Leu Ser His Ser Ser Gly Ala Val Arg Tyr Leu Met His Val Pro Gly 
                325                 330                 335     


Asn Ala Gly Ala Asp Val Leu Leu Val Gly Ser Glu Ala Phe Val Leu 
            340                 345                 350         


Leu Asp Gly Gln Glu Leu Thr Pro Arg Trp Thr Pro Lys Ala Ala His 
        355                 360                 365             


Val Leu Arg Lys Pro Ile Phe Gly Arg Tyr Lys Pro Asp Thr Leu Ala 
    370                 375                 380                 


Val Ala Val Glu Asn Gly Thr Gly Thr Asp Arg Gln Ile Leu Phe Leu 
385                 390                 395                 400 


Asp Leu Gly Thr Gly Ala Val Leu Cys Ser Leu Ala Leu Pro Ser Leu 
                405                 410                 415     


Pro Gly Gly Pro Leu Ser Ala Ser Leu Pro Thr Ala Asp His Arg Ser 
            420                 425                 430         


Ala Phe Phe Phe Trp Gly Leu His Glu Leu Gly Ser Thr Ser Glu Thr 
        435                 440                 445             


Glu Thr Gly Glu Ala Arg His Ser Leu Tyr Met Phe His Pro Thr Leu 
    450                 455                 460                 


Pro Arg Val Leu Leu Glu Leu Ala Asn Val Ser Thr His Ile Val Ala 
465                 470                 475                 480 


Phe Asp Ala Val Leu Phe Glu Pro Ser Arg His Ala Ala Tyr Ile Leu 
                485                 490                 495     


Leu Thr Gly Pro Ala Asp Ser Glu Ala Pro Gly Leu Val Ser Val Ile 
            500                 505                 510         


Lys His Lys Val Arg Asp Leu Val Pro Ser Ser Arg Val Val Arg Leu 
        515                 520                 525             


Gly Glu Gly Gly Pro Asp Ser Asp Gln Ala Ile Arg Asp Arg Phe Ser 
    530                 535                 540                 


Arg Leu Arg Tyr Gln Ser Glu Ala 
545                 550         


<210>  5285
<211>  492
<212>  PRT
<213>  Homo sapiens

<400>  5285

Met Ala Pro Pro Ala Ala Arg Leu Ala Leu Leu Ser Ala Ala Ala Leu 
1               5                   10                  15      


Thr Leu Ala Ala Arg Pro Ala Pro Ser Pro Gly Leu Gly Pro Gly Pro 
            20                  25                  30          


Glu Cys Phe Thr Ala Asn Gly Ala Asp Tyr Arg Gly Thr Gln Asn Trp 
        35                  40                  45              


Thr Ala Leu Gln Gly Gly Lys Pro Cys Leu Phe Trp Asn Glu Thr Phe 
    50                  55                  60                  


Gln His Pro Tyr Asn Thr Leu Lys Tyr Pro Asn Gly Glu Gly Gly Leu 
65                  70                  75                  80  


Gly Glu His Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Ser Pro Trp 
                85                  90                  95      


Cys Tyr Val Ala Glu His Glu Asp Gly Val Tyr Trp Lys Tyr Cys Glu 
            100                 105                 110         


Ile Pro Ala Cys Gln Met Pro Gly Asn Leu Gly Cys Tyr Lys Asp His 
        115                 120                 125             


Gly Asn Pro Pro Pro Leu Thr Gly Thr Ser Lys Thr Ser Asn Lys Leu 
    130                 135                 140                 


Thr Ile Gln Thr Cys Ile Ser Phe Cys Arg Ser Gln Arg Phe Lys Phe 
145                 150                 155                 160 


Ala Gly Met Glu Ser Gly Tyr Ala Cys Phe Cys Gly Asn Asn Pro Asp 
                165                 170                 175     


Tyr Trp Lys Tyr Gly Glu Ala Ala Ser Thr Glu Cys Asn Ser Val Cys 
            180                 185                 190         


Phe Gly Asp His Thr Gln Pro Cys Gly Gly Asp Gly Arg Ile Ile Leu 
        195                 200                 205             


Phe Asp Thr Leu Val Gly Ala Cys Gly Gly Asn Tyr Ser Ala Met Ser 
    210                 215                 220                 


Ser Val Val Tyr Ser Pro Asp Phe Pro Asp Thr Tyr Ala Thr Gly Arg 
225                 230                 235                 240 


Val Cys Tyr Trp Thr Ile Arg Val Pro Gly Ala Ser His Ile His Phe 
                245                 250                 255     


Ser Phe Pro Leu Phe Asp Ile Arg Asp Ser Ala Asp Met Val Glu Leu 
            260                 265                 270         


Leu Asp Gly Tyr Thr His Arg Val Leu Ala Arg Phe His Gly Arg Ser 
        275                 280                 285             


Arg Pro Pro Leu Ser Phe Asn Val Ser Leu Asp Phe Val Ile Leu Tyr 
    290                 295                 300                 


Phe Phe Ser Asp Arg Ile Asn Gln Ala Gln Gly Phe Ala Val Leu Tyr 
305                 310                 315                 320 


Gln Ala Val Lys Glu Glu Leu Pro Gln Glu Arg Pro Ala Val Asn Gln 
                325                 330                 335     


Thr Val Ala Glu Val Ile Thr Glu Gln Ala Asn Leu Ser Val Ser Ala 
            340                 345                 350         


Ala Arg Ser Ser Lys Val Leu Tyr Val Ile Thr Thr Ser Pro Ser His 
        355                 360                 365             


Pro Pro Gln Thr Val Pro Gly Ser Asn Ser Trp Ala Pro Pro Met Gly 
    370                 375                 380                 


Ala Gly Ser His Arg Val Glu Gly Trp Thr Val Tyr Gly Leu Ala Thr 
385                 390                 395                 400 


Leu Leu Ile Leu Thr Val Thr Ala Ile Val Ala Lys Ile Leu Leu His 
                405                 410                 415     


Val Thr Phe Lys Ser His Arg Val Pro Ala Ser Gly Asp Leu Arg Asp 
            420                 425                 430         


Cys His Gln Pro Gly Thr Ser Gly Glu Ile Trp Ser Ile Phe Tyr Lys 
        435                 440                 445             


Pro Ser Thr Ser Ile Ser Ile Phe Lys Lys Lys Leu Lys Gly Gln Ser 
    450                 455                 460                 


Gln Gln Asp Asp Arg Asn Pro Leu Ala Ile Gln Asp Ser Glu Val Thr 
465                 470                 475                 480 


Ser Leu Ile Trp Ser Gln Gly Gln Pro Arg Ser Ile 
                485                 490         


<210>  5286
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  5286

Met Arg Met Leu Val Ser Gly Arg Arg Val Lys Lys Trp Gln Leu Ile 
1               5                   10                  15      


Ile Gln Leu Phe Ala Thr Cys Phe Leu Ala Ser Leu Met Phe Phe Trp 
            20                  25                  30          


Glu Pro Ile Asp Asn His Ile Val Ser His Met Lys Ser Tyr Ser Tyr 
        35                  40                  45              


Arg Tyr Leu Ile Asn Ser Tyr Asp Phe Val Asn Asp Thr Leu Ser Leu 
    50                  55                  60                  


Lys His Thr Ser Ala Gly Pro Arg Tyr Gln Tyr Leu Ile Asn His Lys 
65                  70                  75                  80  


Glu Lys Cys Gln Ala Gln Asp Val Leu Leu Leu Leu Phe Val Lys Thr 
                85                  90                  95      


Ala Pro Glu Asn Tyr Asp Arg Arg Ser Gly Ile Arg Arg Thr Trp Gly 
            100                 105                 110         


Asn Glu Asn Tyr Val Arg Ser Gln Leu Asn Ala Asn Ile Lys Thr Leu 
        115                 120                 125             


Phe Ala Leu Gly Thr Pro Asn Pro Leu Glu Gly Glu Glu Leu Gln Arg 
    130                 135                 140                 


Lys Leu Ala Trp Glu Asp Gln Arg Tyr Asn Asp Ile Ile Gln Gln Asp 
145                 150                 155                 160 


Phe Val Asp Ser Phe Tyr Asn Leu Thr Leu Lys Leu Leu Met Gln Phe 
                165                 170                 175     


Ser Trp Ala Asn Thr Tyr Cys Pro His Ala Lys Phe Leu Met Thr Ala 
            180                 185                 190         


Asp Asp Asp Ile Phe Ile His Met Pro Asn Leu Ile Glu Tyr Leu Gln 
        195                 200                 205             


Ser Leu Glu Gln Ile Gly Val Gln Asp Phe Trp Ile Gly Arg Val His 
    210                 215                 220                 


Arg Gly Ala Pro Pro Ile Arg Asp Lys Ser Ser Lys Tyr Tyr Val Ser 
225                 230                 235                 240 


Tyr Glu Met Tyr Gln Trp Pro Ala Tyr Pro Asp Tyr Thr Ala Gly Ala 
                245                 250                 255     


Ala Tyr Val Ile Ser Gly Asp Val Ala Ala Lys Val Tyr Glu Ala Ser 
            260                 265                 270         


Gln Thr Leu Asn Ser Ser Leu Tyr Ile Asp Asp Val Phe Met Gly Leu 
        275                 280                 285             


Cys Ala Asn Lys Ile Gly Ile Val Pro Gln Asp His Val Phe Phe Ser 
    290                 295                 300                 


Gly Glu Gly Lys Thr Pro Tyr His Pro Cys Ile Tyr Glu Lys Met Met 
305                 310                 315                 320 


Thr Ser His Gly His Leu Glu Asp Leu Gln Asp Leu Trp Lys Asn Ala 
                325                 330                 335     


Thr Asp Pro Lys Val Lys Thr Ile Ser Lys Gly Phe Phe Gly Gln Ile 
            340                 345                 350         


Tyr Cys Arg Leu Met Lys Ile Ile Leu Leu Cys Lys Ile Ser Tyr Val 
        355                 360                 365             


Asp Thr Tyr Pro Cys Arg Ala Ala Phe Ile 
    370                 375             


<210>  5287
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  5287

Met Leu Thr Phe Thr Ser Glu Cys Gly Cys Thr Thr Phe Gly Val Phe 
1               5                   10                  15      


Asp Ile Val Phe Ala Thr Asn Ser Thr Gln Val Ile Lys Met Ile Leu 
            20                  25                  30          


Asn Ser Ser Thr Glu Asp Gly Ile Lys Arg Ile Gln Asp Asp Cys Pro 
        35                  40                  45              


Lys Ala Gly Arg His Asn Tyr Ile Phe Val Met Ile Pro Thr Leu Tyr 
    50                  55                  60                  


Ser Ile Ile Phe Val Val Gly Ile Phe Gly Asn Ser Leu Val Val Ile 
65                  70                  75                  80  


Val Ile Tyr Phe Tyr Met Lys Leu Lys Thr Val Ala Ser Val Phe Leu 
                85                  90                  95      


Leu Asn Leu Ala Leu Ala Asp Leu Cys Phe Leu Leu Thr Leu Pro Leu 
            100                 105                 110         


Trp Ala Val Tyr Thr Ala Met Glu Tyr Arg Trp Pro Phe Gly Asn Tyr 
        115                 120                 125             


Leu Cys Lys Ile Ala Ser Ala Ser Val Ser Phe Asn Leu Tyr Ala Ser 
    130                 135                 140                 


Val Phe Leu Leu Thr Cys Leu Ser Ile Asp Arg Tyr Leu Ala Ile Val 
145                 150                 155                 160 


His Pro Met Lys Ser Arg Leu Arg Arg Thr Met Leu Val Ala Lys Val 
                165                 170                 175     


Thr Cys Ile Ile Ile Trp Leu Leu Ala Gly Leu Ala Ser Leu Pro Ala 
            180                 185                 190         


Ile Ile His Arg Asn Val Phe Phe Ile Glu Asn Thr Asn Ile Thr Val 
        195                 200                 205             


Cys Ala Phe His Tyr Glu Ser Gln Asn Ser Thr Leu Pro Ile Gly Leu 
    210                 215                 220                 


Gly Leu Thr Lys Asn Ile Leu Gly Phe Leu Phe Pro Phe Leu Ile Ile 
225                 230                 235                 240 


Leu Thr Ser Tyr Thr Leu Ile Trp Lys Ala Leu Lys Lys Ala Tyr Glu 
                245                 250                 255     


Ile Gln Lys Asn Lys Pro Arg Asn Asp Asp Ile Phe Lys Ile Ile Met 
            260                 265                 270         


Ala Ile Val Leu Phe Phe Phe Phe Ser Trp Ile Pro His Gln Ile Phe 
        275                 280                 285             


Thr Phe Leu Asp Val Leu Ile Gln Leu Gly Ile Ile Arg Asp Cys Arg 
    290                 295                 300                 


Ile Ala Asp Ile Val Asp Thr Ala Met Pro Ile Thr Ile Cys Ile Ala 
305                 310                 315                 320 


Tyr Phe Asn Asn Cys Leu Asn Pro Leu Phe Tyr Gly Phe Leu Gly Lys 
                325                 330                 335     


Lys Phe Lys Arg Tyr Phe Leu Gln Leu Leu Lys Tyr Ile Pro Pro Lys 
            340                 345                 350         


Ala Lys Ser His Ser Asn Leu Ser Thr Lys Met Ser Thr Leu Ser Tyr 
        355                 360                 365             


Arg Pro Ser Asp Asn Val Ser Ser Ser Thr Lys Lys Pro Ala Pro Cys 
    370                 375                 380                 


Phe Glu Val Glu 
385             


<210>  5288
<211>  828
<212>  PRT
<213>  Homo sapiens

<400>  5288

Met Ala Ala Pro Thr Lys Cys Gln Leu Arg Gly Arg Leu Val Leu Leu 
1               5                   10                  15      


Cys Ser Leu Leu Gly Met Leu Trp Glu Ala Arg Ala Ser Gln Ile Arg 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Thr Glu Lys Gly Tyr Ile Val Gly Asn Ile 
        35                  40                  45              


Ser Lys Asp Leu Ala Leu Glu Pro Arg Glu Leu Ala Glu Arg Arg Val 
    50                  55                  60                  


Arg Ile Val Ser Arg Gly Arg Thr Gln Leu Phe Ser Leu Asn Pro Arg 
65                  70                  75                  80  


Ser Gly Thr Leu Val Thr Ala Gly Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Ala Gln Ser Pro Arg Cys Leu Val Asn Phe Lys Val Leu Val Glu Asp 
            100                 105                 110         


Arg Val Lys Leu Tyr Gly Ile Glu Ile Glu Val Thr Asp Ile Asn Asp 
        115                 120                 125             


Ser Ala Pro Lys Phe Gln Ala Glu Ser Leu Glu Val Lys Ile Asn Glu 
    130                 135                 140                 


Ile Ala Val Pro Gly Ala Arg Tyr Pro Leu Pro Glu Ala Ile Asp Pro 
145                 150                 155                 160 


Asp Val Gly Val Asn Ser Leu Gln Ser Tyr Gln Leu Ser Pro Asn His 
                165                 170                 175     


His Phe Ser Leu Asn Val Gln Thr Gly Asp Asn Gly Ala Ile Asn Pro 
            180                 185                 190         


Glu Leu Val Leu Glu Arg Ala Leu Asp Arg Glu Glu Ala Thr Ala His 
        195                 200                 205             


His Leu Val Leu Thr Ala Ser Asp Gly Gly Glu Pro Arg Arg Ser Ser 
    210                 215                 220                 


Thr Val Arg Ile His Val Thr Val Leu Asp Thr Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Val Phe Ala Gln Arg Ile Tyr Arg Val Lys Val Leu Glu Asn Val Pro 
                245                 250                 255     


Pro Gly Thr Trp Leu Leu Thr Ala Thr Ala Ser Asp Leu Asp Glu Gly 
            260                 265                 270         


Ile Asn Gly Lys Val Ala Tyr Lys Phe Trp Lys Ile Asn Glu Lys Gln 
        275                 280                 285             


Ser Leu Leu Phe Gln Leu Asn Glu Asn Thr Gly Glu Ile Ser Thr Ala 
    290                 295                 300                 


Lys Ser Leu Asp Tyr Glu Glu Cys Ser Phe Tyr Glu Met Glu Ile Gln 
305                 310                 315                 320 


Ala Glu Asp Gly Gly Gly Leu Lys Gly Trp Thr Lys Val Leu Ile Ser 
                325                 330                 335     


Val Glu Asp Val Asn Asp Asn Arg Pro Glu Val Thr Ile Thr Ser Leu 
            340                 345                 350         


Phe Ser Pro Val Arg Glu Asp Ala Pro Gln Gly Thr Val Ile Leu Leu 
        355                 360                 365             


Phe Asn Ala His Asp Arg Asp Ser Gly Lys Asn Gly Gln Val Val Cys 
    370                 375                 380                 


Ser Ile Gln Glu Asn Leu Ser Phe Thr Leu Glu Asn Ser Glu Glu Asp 
385                 390                 395                 400 


Tyr Tyr Arg Leu Leu Thr Ala Gln Ile Leu Asp Arg Glu Lys Ala Ser 
                405                 410                 415     


Glu Tyr Asn Ile Thr Val Thr Ala Thr Asp Arg Gly Thr Pro Pro Leu 
            420                 425                 430         


Ser Thr Glu Ile His Ile Thr Leu Gln Val Thr Asp Ile Asn Asp Asn 
        435                 440                 445             


Pro Pro Ala Phe Ser Gln Ala Ser Tyr Ser Val Tyr Leu Pro Glu Asn 
    450                 455                 460                 


Asn Ala Arg Gly Thr Ser Ile Phe Ser Val Ile Ala Tyr Asp Pro Asp 
465                 470                 475                 480 


Ser Asn Glu Asn Ser Arg Val Ile Tyr Ser Leu Ala Glu Asp Thr Ile 
                485                 490                 495     


Gln Gly Ser Pro Leu Ser Thr Tyr Val Ser Ile Asn Ser Asp Thr Gly 
            500                 505                 510         


Val Leu Tyr Ala Leu Cys Ser Phe Asp Tyr Glu Gln Phe Arg Asp Leu 
        515                 520                 525             


Gln Met Gln Val Thr Ala Ser Asp Ser Gly Ser Pro Pro Leu Ser Ser 
    530                 535                 540                 


Asn Val Ser Leu Arg Leu Phe Val Leu Asp Gln Asn Asp Asn Ala Pro 
545                 550                 555                 560 


Glu Ile Leu Tyr Pro Ala Leu Pro Thr Asp Gly Ser Thr Gly Val Glu 
                565                 570                 575     


Leu Ala Pro Arg Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val 
            580                 585                 590         


Ala Val Asp Arg Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Arg Leu 
        595                 600                 605             


Phe Lys Ala Ser Glu Pro Gly Leu Phe Ser Val Gly Leu His Thr Gly 
    610                 615                 620                 


Glu Val Arg Thr Ala Arg Ala Leu Leu Asp Arg Asp Ala Leu Lys Gln 
625                 630                 635                 640 


Ser Leu Val Val Ala Val Gln Asp His Gly Gln Pro Pro Leu Ser Ala 
                645                 650                 655     


Thr Val Thr Leu Thr Val Ala Ile Ala Asp Ser Ile Pro Asp Ile Leu 
            660                 665                 670         


Ala Asp Leu Gly Ser Leu Gln Ile Pro Ala Asp Leu Glu Ala Ser Asp 
        675                 680                 685             


Leu Thr Leu Tyr Leu Val Val Ala Val Ala Val Val Ser Cys Val Phe 
    690                 695                 700                 


Leu Thr Phe Val Ile Thr Leu Leu Ala Leu Arg Leu Arg His Trp His 
705                 710                 715                 720 


Ser Ser His Leu Leu Arg Ala Thr Ser Asp Gly Leu Ala Gly Val Pro 
                725                 730                 735     


Thr Ser His Phe Val Gly Val Asp Gly Val Arg Ala Phe Leu Gln Thr 
            740                 745                 750         


Tyr Ser Gln Glu Phe Ser Leu Thr Ala Asp Ser Arg Lys Ser His Leu 
        755                 760                 765             


Ile Phe Pro Gln Pro Asn Tyr Ala Asp Thr Leu Ile Ser Gln Gln Ser 
    770                 775                 780                 


Cys Glu Lys Asn Glu Pro Leu Cys Val Ser Val Asp Ser Lys Phe Pro 
785                 790                 795                 800 


Ile Glu Asp Thr Pro Leu Val Pro Val Ser Ser Phe Phe Phe Phe Leu 
                805                 810                 815     


Ser Phe Leu Phe Leu Phe Phe Val Leu Phe Cys Phe 
            820                 825             


<210>  5289
<211>  850
<212>  PRT
<213>  Homo sapiens

<400>  5289

Met Ala Ala Gln Arg Asn Arg Ser Lys Glu Ser Lys Asp Cys Ser Gly 
1               5                   10                  15      


Leu Val Leu Leu Cys Leu Phe Phe Gly Ile Pro Trp Glu Ala Gly Ala 
            20                  25                  30          


Arg Gln Ile Ser Tyr Ser Ile Pro Glu Glu Leu Glu Lys Gly Ser Phe 
        35                  40                  45              


Val Gly Asn Ile Ser Lys Asp Leu Gly Leu Ala Pro Arg Glu Leu Ala 
    50                  55                  60                  


Glu Arg Gly Val Arg Ile Val Ser Arg Gly Arg Thr Gln Leu Phe Ser 
65                  70                  75                  80  


Leu Asn Pro Arg Ser Gly Ser Leu Ile Thr Ala Gly Arg Ile Asp Arg 
                85                  90                  95      


Glu Glu Leu Cys Ala Gln Ser Ala Arg Cys Val Val Ser Phe Asn Ile 
            100                 105                 110         


Leu Val Glu Asp Arg Val Lys Leu Phe Gly Ile Glu Ile Glu Val Thr 
        115                 120                 125             


Asp Ile Asn Asp Asn Ala Pro Lys Phe Gln Ala Glu Asn Leu Asp Val 
    130                 135                 140                 


Lys Ile Asn Glu Asn Val Ala Ala Gly Met Arg Phe Pro Leu Pro Glu 
145                 150                 155                 160 


Ala Ile Asp Pro Asp Val Gly Val Asn Ser Leu Gln Ser Tyr Gln Leu 
                165                 170                 175     


Ser Pro Asn Lys His Phe Ser Leu Arg Val Gln Ser Arg Ala Asn Gly 
            180                 185                 190         


Val Lys Tyr Pro Glu Leu Val Leu Glu His Ser Leu Asp Arg Glu Glu 
        195                 200                 205             


Glu Ala Ile His His Leu Val Leu Thr Ala Ser Asp Gly Gly Asp Pro 
    210                 215                 220                 


Leu Arg Ser Gly Thr Val Leu Val Ser Val Thr Val Phe Asp Ala Asn 
225                 230                 235                 240 


Asp Asn Ala Pro Val Phe Thr Leu Pro Glu Tyr Arg Val Ser Val Pro 
                245                 250                 255     


Glu Asn Leu Pro Val Gly Thr Gln Leu Leu Thr Val Thr Ala Thr Asp 
            260                 265                 270         


Arg Asp Glu Gly Ala Asn Gly Glu Val Thr Tyr Ser Phe Arg Lys Leu 
        275                 280                 285             


Pro Asp Thr Gln Leu Leu Lys Phe Gln Leu Asn Lys Tyr Thr Gly Glu 
    290                 295                 300                 


Ile Lys Ile Ser Glu Asn Leu Asp Tyr Glu Glu Thr Gly Phe Tyr Glu 
305                 310                 315                 320 


Ile Glu Ile Gln Ala Glu Asp Gly Gly Ala Tyr Leu Ala Thr Ala Lys 
                325                 330                 335     


Val Leu Ile Thr Val Glu Asp Val Asn Asp Asn Ser Pro Glu Leu Thr 
            340                 345                 350         


Ile Thr Ser Leu Phe Ser Pro Val Thr Glu Asp Ser Pro Leu Gly Thr 
        355                 360                 365             


Val Val Ala Leu Leu Asn Val His Asp Leu Asp Ser Glu Gln Asn Gly 
    370                 375                 380                 


Gln Val Thr Cys Ser Ile Leu Ala Tyr Leu Pro Phe Lys Leu Glu Lys 
385                 390                 395                 400 


Ser Ile Asp Ser Tyr Tyr Arg Leu Val Ile His Arg Ala Leu Asp Arg 
                405                 410                 415     


Glu Gln Val Ser Ser Tyr Asn Ile Thr Val Thr Ala Thr Asp Gly Gly 
            420                 425                 430         


Ser Pro Pro Leu Ser Thr Glu Ala His Phe Met Leu Gln Val Ala Asp 
        435                 440                 445             


Ile Asn Asp Asn Pro Pro Thr Phe Ser Gln Val Ser Tyr Phe Thr Tyr 
    450                 455                 460                 


Ile Pro Glu Asn Asn Ala Arg Gly Ala Ser Ile Phe Ser Val Thr Ala 
465                 470                 475                 480 


Leu Asp Pro Asp Ser Lys Glu Asn Ala Gln Ile Ile Tyr Ser Leu Ala 
                485                 490                 495     


Glu Asp Thr Ile Gln Gly Val Pro Leu Ser Ser Tyr Ile Ser Ile Asn 
            500                 505                 510         


Ser Asp Thr Gly Val Leu Tyr Ala Leu Arg Ser Phe Asp Tyr Glu Gln 
        515                 520                 525             


Phe His Glu Leu Gln Met Gln Val Thr Ala Ser Asp Ser Gly Asp Pro 
    530                 535                 540                 


Pro Leu Ser Ser Asn Val Ser Leu Ser Leu Phe Val Leu Asp Gln Asn 
545                 550                 555                 560 


Asp Asn Ala Pro Glu Ile Leu Tyr Pro Ala Leu Pro Thr Asp Gly Ser 
                565                 570                 575     


Thr Gly Val Glu Leu Ala Pro Arg Ser Ala Glu Pro Gly Tyr Leu Val 
            580                 585                 590         


Thr Lys Val Val Ala Val Asp Arg Asp Ser Gly Gln Asn Ala Trp Leu 
        595                 600                 605             


Ser Tyr Arg Leu Leu Lys Ala Ser Glu Pro Gly Leu Phe Ala Val Gly 
    610                 615                 620                 


Glu His Thr Gly Glu Val Arg Thr Ala Arg Ala Leu Leu Asp Arg Asp 
625                 630                 635                 640 


Ala Leu Lys Gln Ser Leu Val Val Ala Val Gln Asp His Gly Gln Pro 
                645                 650                 655     


Pro Leu Ser Ala Thr Val Thr Leu Thr Val Ala Val Ala Asp Ser Ile 
            660                 665                 670         


Pro Gln Val Leu Ala Asp Leu Gly Ser Phe Glu Ser Pro Ala Asn Ser 
        675                 680                 685             


Glu Thr Ser Asp Leu Thr Leu Tyr Leu Val Val Ala Val Ala Ala Val 
    690                 695                 700                 


Ser Cys Val Phe Leu Ala Phe Val Ile Val Leu Leu Ala His Arg Leu 
705                 710                 715                 720 


Arg Arg Trp His Lys Ser Arg Leu Leu Gln Ala Ser Gly Gly Gly Leu 
                725                 730                 735     


Thr Gly Val Ser Gly Ser His Phe Val Gly Val Asp Gly Val Arg Ala 
            740                 745                 750         


Phe Leu Gln Thr Tyr Ser His Glu Val Ser Leu Thr Ala Asp Ser Arg 
        755                 760                 765             


Lys Ser His Leu Ile Phe Pro Gln Pro Asn Tyr Ala Asp Thr Leu Ile 
    770                 775                 780                 


Ser Gln Glu Ser Cys Glu Lys Asn Asp Pro Leu Ser Leu Leu Asp Asp 
785                 790                 795                 800 


Ser Lys Phe Pro Ile Glu Asp Thr Pro Leu Val Pro Val Ser Phe Ile 
                805                 810                 815     


Phe Ile Phe Thr Phe Val Lys Lys Lys Lys Ile Gly Phe Tyr Phe Glu 
            820                 825                 830         


Val Cys Gly Met Met Val Glu Ser Val Asn Ala Lys Thr Leu Met Ser 
        835                 840                 845             


Arg Ile 
    850 


<210>  5290
<211>  837
<212>  PRT
<213>  Homo sapiens

<400>  5290

Met Ala Asn Arg Leu Gln Arg Gly Asp Arg Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Cys Ile Phe Leu Gly Thr Leu Arg Gly Phe Arg Ala Arg Gln Ile 
            20                  25                  30          


Arg Tyr Ser Val Pro Glu Glu Thr Glu Lys Gly Ser Phe Val Gly Asn 
        35                  40                  45              


Ile Ser Lys Asp Leu Gly Leu Glu Pro Arg Glu Leu Ala Lys Arg Gly 
    50                  55                  60                  


Val Arg Ile Val Ser Arg Gly Lys Thr Gln Leu Phe Ala Val Asn Pro 
65                  70                  75                  80  


Arg Ser Gly Ser Leu Ile Thr Ala Gly Arg Ile Asp Arg Glu Glu Leu 
                85                  90                  95      


Cys Glu Thr Val Ser Ser Cys Phe Leu Asn Met Glu Leu Leu Val Glu 
            100                 105                 110         


Asp Thr Leu Lys Ile Tyr Gly Val Glu Val Glu Ile Ile Asp Ile Asn 
        115                 120                 125             


Asp Asn Ala Pro Ser Phe Gln Glu Asp Glu Val Glu Ile Lys Val Ser 
    130                 135                 140                 


Glu His Ala Ile Pro Gly Ala Arg Phe Ala Leu Pro Asn Ala Arg Asp 
145                 150                 155                 160 


Pro Asp Val Gly Val Asn Ser Leu Gln Ser Tyr Gln Leu Ser Pro Asn 
                165                 170                 175     


Asn Tyr Phe Ser Leu Gln Leu Arg Gly Arg Thr Asp Gly Ala Lys Asn 
            180                 185                 190         


Pro Glu Leu Val Leu Glu Gly Ser Leu Asp Arg Glu Lys Glu Ala Ala 
        195                 200                 205             


His Leu Leu Leu Leu Thr Ala Leu Asp Gly Gly Asp Pro Ile Arg Lys 
    210                 215                 220                 


Gly Ala Val Pro Ile Arg Val Val Val Leu Asp Val Asn Asp His Ile 
225                 230                 235                 240 


Pro Met Phe Thr Gln Ser Val Tyr Arg Val Ser Val Pro Glu Asn Ile 
                245                 250                 255     


Ser Ser Gly Thr Arg Val Leu Met Val Asn Ala Thr Asp Pro Asp Glu 
            260                 265                 270         


Gly Ile Asn Gly Glu Val Met Tyr Ser Phe Arg Asn Met Glu Ser Lys 
        275                 280                 285             


Ala Ser Glu Ile Phe Gln Leu Asp Ser Gln Thr Gly Glu Val Gln Val 
    290                 295                 300                 


Arg Gly Ser Leu Asp Phe Glu Lys Tyr Arg Phe Tyr Glu Met Glu Ile 
305                 310                 315                 320 


Gln Gly Gln Asp Gly Gly Gly Leu Phe Thr Thr Thr Thr Met Leu Ile 
                325                 330                 335     


Thr Val Val Asp Val Asn Asp Asn Ala Pro Glu Ile Thr Ile Thr Ser 
            340                 345                 350         


Ser Ile Asn Ser Ile Leu Glu Asn Ser Pro Pro Gly Thr Val Ile Ala 
        355                 360                 365             


Leu Leu Asn Val Gln Asp Gln Asp Ser Gly Glu Asn Gly Gln Val Ser 
    370                 375                 380                 


Cys Phe Ile Pro Asn His Leu Pro Phe Lys Leu Glu Lys Thr Tyr Gly 
385                 390                 395                 400 


Asn Tyr Tyr Lys Leu Ile Thr Ser Arg Val Leu Asp Arg Glu Leu Val 
                405                 410                 415     


Gln Ser Tyr Asn Ile Thr Leu Thr Ala Thr Asp Gln Gly Ser Pro Pro 
            420                 425                 430         


Leu Ser Ala Glu Thr His Val Trp Leu Asn Val Ala Asp Asp Asn Asp 
        435                 440                 445             


Asn Pro Pro Val Phe Pro His Ser Ser Tyr Ser Ala Tyr Ile Pro Glu 
    450                 455                 460                 


Asn Asn Pro Arg Gly Ala Ser Ile Phe Ser Val Thr Ala Leu Asp Pro 
465                 470                 475                 480 


Asp Ser Lys Gln Asn Ala Leu Val Thr Tyr Ser Leu Thr Asp Asp Thr 
                485                 490                 495     


Val Gln Gly Val Pro Leu Ser Ser Tyr Val Ser Ile Asn Ser Asn Thr 
            500                 505                 510         


Gly Val Leu Tyr Ala Leu Gln Ser Phe Asp Tyr Glu Gln Phe Arg Asp 
        515                 520                 525             


Leu Glu Leu Arg Val Ile Ala Arg Asp Ser Gly Asp Pro Pro Leu Ser 
    530                 535                 540                 


Ser Asn Val Ser Leu Ser Leu Phe Val Leu Asp Gln Asn Asp Asn Ala 
545                 550                 555                 560 


Pro Glu Ile Leu Tyr Pro Ala Leu Pro Thr Asp Gly Ser Thr Gly Val 
                565                 570                 575     


Glu Leu Ala Pro Arg Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val 
            580                 585                 590         


Val Ala Val Asp Lys Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Arg 
        595                 600                 605             


Leu Leu Lys Ala Ser Glu Pro Gly Leu Phe Ala Val Gly Glu His Thr 
    610                 615                 620                 


Gly Glu Val Arg Thr Ala Arg Ala Leu Leu Asp Arg Asp Ala Leu Lys 
625                 630                 635                 640 


Gln Ser Leu Val Val Ala Val Gln Asp His Gly Gln Pro Pro Leu Ser 
                645                 650                 655     


Ala Thr Val Thr Leu Thr Val Ala Val Ala Asp Ser Ile Pro Glu Val 
            660                 665                 670         


Leu Ala Asp Leu Gly Ser Leu Glu Ser Leu Ala Asn Ser Glu Thr Ser 
        675                 680                 685             


Asp Leu Ser Leu Tyr Leu Val Val Ala Val Ala Ala Val Ser Cys Ile 
    690                 695                 700                 


Phe Leu Val Phe Val Ile Val Leu Leu Ala Leu Arg Leu Trp Arg Trp 
705                 710                 715                 720 


His Lys Ser Arg Leu Leu Gln Ala Ser Glu Gly Gly Leu Ala Gly Met 
                725                 730                 735     


Pro Thr Ser His Phe Val Gly Val Asp Gly Val Gln Ala Phe Leu Gln 
            740                 745                 750         


Thr Tyr Ser His Glu Val Ser Leu Ile Ala Asp Ser Gln Lys Ser His 
        755                 760                 765             


Leu Ile Phe Pro Gln Pro Asn Tyr Gly Asp Thr Leu Ile Ser Gln Glu 
    770                 775                 780                 


Ser Cys Glu Lys Ser Glu Pro Leu Leu Ile Ala Glu Asp Ser Ala Ile 
785                 790                 795                 800 


Ile Leu Gly Lys Cys Asp Pro Thr Ser Asn Gln Val Arg Phe Ile Ser 
                805                 810                 815     


Leu Pro Pro Asn Cys Trp Cys Leu Gly Thr Ser Leu Leu Arg Arg Cys 
            820                 825                 830         


Phe Leu Ser Leu Leu 
        835         


<210>  5291
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  5291

Met Ala Asn Arg Leu Gln Arg Gly Asp Arg Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Cys Ile Phe Leu Gly Thr Leu Arg Gly Phe Arg Ala Arg Gln Ile 
            20                  25                  30          


Arg Tyr Ser Val Pro Glu Glu Thr Glu Lys Gly Ser Phe Val Gly Asn 
        35                  40                  45              


Ile Ser Lys Asp Leu Gly Leu Glu Pro Arg Glu Leu Ala Lys Arg Gly 
    50                  55                  60                  


Val Arg Ile Val Ser Arg Gly Lys Thr Gln Leu Phe Ala Val Asn Pro 
65                  70                  75                  80  


Arg Ser Gly Ser Leu Ile Thr Ala Gly Arg Ile Asp Arg Glu Glu Leu 
                85                  90                  95      


Cys Glu Thr Val Ser Ser Cys Phe Leu Asn Met Glu Leu Leu Val Glu 
            100                 105                 110         


Asp Thr Leu Lys Ile Tyr Gly Val Glu Val Glu Ile Ile Asp Ile Asn 
        115                 120                 125             


Asp Asn Ala Pro Ser Phe Gln Glu Asp Glu Val Glu Ile Lys Val Ser 
    130                 135                 140                 


Glu His Ala Ile Pro Gly Ala Arg Phe Ala Leu Pro Asn Ala Arg Asp 
145                 150                 155                 160 


Pro Asp Val Gly Val Asn Ser Leu Gln Ser Tyr Gln Leu Ser Pro Asn 
                165                 170                 175     


Asn Tyr Phe Ser Leu Gln Leu Arg Gly Arg Thr Asp Gly Ala Lys Asn 
            180                 185                 190         


Pro Glu Leu Val Leu Glu Gly Ser Leu Asp Arg Glu Lys Glu Ala Ala 
        195                 200                 205             


His Leu Leu Leu Leu Thr Ala Leu Asp Gly Gly Asp Pro Ile Arg Lys 
    210                 215                 220                 


Gly Ala Val Pro Ile Arg Val Val Val Leu Asp Val Asn Asp His Ile 
225                 230                 235                 240 


Pro Met Phe Thr Gln Ser Val Tyr Arg Val Ser Val Pro Glu Asn Ile 
                245                 250                 255     


Ser Ser Gly Thr Arg Val Leu Met Val Asn Ala Thr Asp Pro Asp Glu 
            260                 265                 270         


Gly Ile Asn Gly Glu Val Met Tyr Ser Phe Arg Asn Met Glu Ser Lys 
        275                 280                 285             


Ala Ser Glu Ile Phe Gln Leu Asp Ser Gln Thr Gly Glu Val Gln Val 
    290                 295                 300                 


Arg Gly Ser Leu Asp Phe Glu Lys Tyr Arg Phe Tyr Glu Met Glu Ile 
305                 310                 315                 320 


Gln Gly Gln Asp Gly Gly Gly Leu Phe Thr Thr Thr Thr Met Leu Ile 
                325                 330                 335     


Thr Val Val Asp Val Asn Asp Asn Ala Pro Glu Ile Thr Ile Thr Ser 
            340                 345                 350         


Ser Ile Asn Ser Ile Leu Glu Asn Ser Pro Pro Gly Thr Val Ile Ala 
        355                 360                 365             


Leu Leu Asn Val Gln Asp Gln Asp Ser Gly Glu Asn Gly Gln Val Ser 
    370                 375                 380                 


Cys Phe Ile Pro Asn His Leu Pro Phe Lys Leu Glu Lys Thr Tyr Gly 
385                 390                 395                 400 


Asn Tyr Tyr Lys Leu Ile Thr Ser Arg Val Leu Asp Arg Glu Leu Val 
                405                 410                 415     


Gln Ser Tyr Asn Ile Thr Leu Thr Ala Thr Asp Gln Gly Ser Pro Pro 
            420                 425                 430         


Leu Ser Ala Glu Thr His Val Trp Leu Asn Val Ala Asp Asp Asn Asp 
        435                 440                 445             


Asn Pro Pro Val Phe Pro His Ser Ser Tyr Ser Ala Tyr Ile Pro Glu 
    450                 455                 460                 


Asn Asn Pro Arg Gly Ala Ser Ile Phe Ser Val Thr Ala Leu Asp Pro 
465                 470                 475                 480 


Asp Ser Lys Gln Asn Ala Leu Val Thr Tyr Ser Leu Thr Asp Asp Thr 
                485                 490                 495     


Val Gln Gly Val Pro Leu Ser Ser Tyr Val Ser Ile Asn Ser Asn Thr 
            500                 505                 510         


Gly Val Leu Tyr Ala Leu Gln Ser Phe Asp Tyr Glu Gln Phe Arg Asp 
        515                 520                 525             


Leu Glu Leu Arg Val Ile Ala Arg Asp Ser Gly Asp Pro Pro Leu Ser 
    530                 535                 540                 


Ser Asn Val Ser Leu Ser Leu Phe Val Leu Asp Gln Asn Asp Asn Ala 
545                 550                 555                 560 


Pro Glu Ile Leu Tyr Pro Ala Leu Pro Thr Asp Gly Ser Thr Gly Val 
                565                 570                 575     


Glu Leu Ala Pro Arg Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val 
            580                 585                 590         


Val Ala Val Asp Lys Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Arg 
        595                 600                 605             


Leu Leu Lys Ala Ser Glu Pro Gly Leu Phe Ala Val Gly Glu His Thr 
    610                 615                 620                 


Gly Glu Gln Ala Pro Pro Asn Thr Asp Trp Arg Phe Ser Gln Ala Gln 
625                 630                 635                 640 


Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly Asp Asp Thr Gly Thr Trp 
                645                 650                 655     


Pro Asn Asn Gln Phe Asp Thr Glu Met Leu Gln Ala Met Ile Leu Ala 
            660                 665                 670         


Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser Thr Leu Gly Gly Gly Ala 
        675                 680                 685             


Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly Pro Gln Phe Thr Leu Gln 
    690                 695                 700                 


His Val Pro Asp Tyr Arg Gln Asn Val Tyr Ile Pro Gly Ser Asn Ala 
705                 710                 715                 720 


Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp Gly Lys Ala Pro Ala Gly 
                725                 730                 735     


Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys Lys Glu Lys Lys 
            740                 745                 750 


<210>  5292
<211>  934
<212>  PRT
<213>  Homo sapiens

<400>  5292

Met Val Pro Glu Ala Trp Arg Ser Gly Leu Val Ser Thr Gly Arg Val 
1               5                   10                  15      


Val Gly Val Leu Leu Leu Leu Gly Ala Leu Asn Lys Ala Ser Thr Val 
            20                  25                  30          


Ile His Tyr Glu Ile Pro Glu Glu Arg Glu Lys Gly Phe Ala Val Gly 
        35                  40                  45              


Asn Val Val Ala Asn Leu Gly Leu Asp Leu Gly Ser Leu Ser Ala Arg 
    50                  55                  60                  


Arg Phe Arg Val Val Ser Gly Ala Ser Arg Arg Phe Phe Glu Val Asn 
65                  70                  75                  80  


Arg Glu Thr Gly Glu Met Phe Val Asn Asp Arg Leu Asp Arg Glu Glu 
                85                  90                  95      


Leu Cys Gly Thr Leu Pro Ser Cys Thr Val Thr Leu Glu Leu Val Val 
            100                 105                 110         


Glu Asn Pro Leu Glu Leu Phe Ser Val Glu Val Val Ile Gln Asp Ile 
        115                 120                 125             


Asn Asp Asn Asn Pro Ala Phe Pro Thr Gln Glu Met Lys Leu Glu Ile 
    130                 135                 140                 


Ser Glu Ala Val Ala Pro Gly Thr Arg Phe Pro Leu Glu Ser Ala His 
145                 150                 155                 160 


Asp Pro Asp Val Gly Ser Asn Ser Leu Gln Thr Tyr Glu Leu Ser Arg 
                165                 170                 175     


Asn Glu Tyr Phe Ala Leu Arg Val Gln Thr Arg Glu Asp Ser Thr Lys 
            180                 185                 190         


Tyr Ala Glu Leu Val Leu Glu Arg Ala Leu Asp Arg Glu Arg Glu Pro 
        195                 200                 205             


Ser Leu Gln Leu Val Leu Thr Ala Leu Asp Gly Gly Thr Pro Ala Leu 
    210                 215                 220                 


Ser Ala Ser Leu Pro Ile His Ile Lys Val Leu Asp Ala Asn Asp Asn 
225                 230                 235                 240 


Ala Pro Val Phe Asn Gln Ser Leu Tyr Arg Ala Arg Val Leu Glu Asp 
                245                 250                 255     


Ala Pro Ser Gly Thr Arg Val Val Gln Val Leu Ala Thr Asp Leu Asp 
            260                 265                 270         


Glu Gly Pro Asn Gly Glu Ile Ile Tyr Ser Phe Gly Ser His Asn Arg 
        275                 280                 285             


Ala Gly Val Arg Gln Leu Phe Ala Leu Asp Leu Val Thr Gly Met Leu 
    290                 295                 300                 


Thr Ile Lys Gly Arg Leu Asp Phe Glu Asp Thr Lys Leu His Glu Ile 
305                 310                 315                 320 


Tyr Ile Gln Ala Lys Asp Lys Gly Ala Asn Pro Glu Gly Ala His Cys 
                325                 330                 335     


Lys Val Leu Val Glu Val Val Asp Val Asn Asp Asn Ala Pro Glu Ile 
            340                 345                 350         


Thr Val Thr Ser Val Tyr Ser Pro Val Pro Glu Asp Ala Pro Leu Gly 
        355                 360                 365             


Thr Val Ile Ala Leu Leu Ser Val Thr Asp Leu Asp Ala Gly Glu Asn 
    370                 375                 380                 


Gly Leu Val Thr Cys Glu Val Pro Pro Gly Leu Pro Phe Ser Leu Thr 
385                 390                 395                 400 


Ser Ser Leu Lys Asn Tyr Phe Thr Leu Lys Thr Ser Ala Asp Leu Asp 
                405                 410                 415     


Arg Glu Thr Val Pro Glu Tyr Asn Leu Ser Ile Thr Ala Arg Asp Ala 
            420                 425                 430         


Gly Thr Pro Ser Leu Ser Ala Leu Thr Ile Val Arg Val Gln Val Ser 
        435                 440                 445             


Asp Ile Asn Asp Asn Pro Pro Gln Ser Ser Gln Ser Ser Tyr Asp Val 
    450                 455                 460                 


Tyr Ile Glu Glu Asn Asn Leu Pro Gly Ala Pro Ile Leu Asn Leu Ser 
465                 470                 475                 480 


Val Trp Asp Pro Asp Ala Pro Gln Asn Ala Arg Leu Ser Phe Phe Leu 
                485                 490                 495     


Leu Glu Gln Gly Ala Glu Thr Gly Leu Val Gly Arg Tyr Phe Thr Ile 
            500                 505                 510         


Asn Arg Asp Asn Gly Ile Val Ser Ser Leu Val Pro Leu Asp Tyr Glu 
        515                 520                 525             


Asp Arg Arg Glu Phe Glu Leu Thr Ala His Ile Ser Asp Gly Gly Thr 
    530                 535                 540                 


Pro Val Leu Ala Thr Asn Ile Ser Val Asn Ile Phe Val Thr Asp Arg 
545                 550                 555                 560 


Asn Asp Asn Ala Pro Gln Val Leu Tyr Pro Arg Pro Gly Gly Ser Ser 
                565                 570                 575     


Val Glu Met Leu Pro Arg Gly Thr Ser Ala Gly His Leu Val Ser Arg 
            580                 585                 590         


Val Val Gly Trp Asp Ala Asp Ala Gly His Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Ser Leu Leu Gly Ser Pro Asn Gln Ser Leu Phe Ala Ile Gly Leu His 
    610                 615                 620                 


Thr Gly Gln Ile Ser Thr Ala Arg Pro Val Gln Asp Thr Asp Ser Pro 
625                 630                 635                 640 


Arg Gln Thr Leu Thr Val Leu Ile Lys Asp Asn Gly Glu Pro Ser Leu 
                645                 650                 655     


Ser Thr Thr Ala Thr Leu Thr Val Ser Val Thr Glu Asp Ser Pro Glu 
            660                 665                 670         


Ala Arg Ala Glu Phe Pro Ser Gly Ser Ala Pro Arg Glu Gln Lys Lys 
        675                 680                 685             


Asn Leu Thr Phe Tyr Leu Leu Leu Ser Leu Ile Leu Val Ser Val Gly 
    690                 695                 700                 


Phe Val Val Thr Val Phe Gly Val Ile Ile Phe Lys Val Tyr Lys Trp 
705                 710                 715                 720 


Lys Gln Ser Arg Asp Leu Tyr Arg Ala Pro Val Ser Ser Leu Tyr Arg 
                725                 730                 735     


Thr Pro Gly Pro Ser Leu His Ala Asp Ala Val Arg Gly Gly Leu Met 
            740                 745                 750         


Ser Pro His Leu Tyr His Gln Val Tyr Leu Thr Thr Asp Ser Arg Arg 
        755                 760                 765             


Ser Asp Pro Leu Leu Lys Lys Pro Gly Ala Ala Ser Pro Leu Ala Ser 
    770                 775                 780                 


Arg Gln Asn Thr Leu Arg Ser Cys Asp Pro Val Phe Tyr Arg Gln Val 
785                 790                 795                 800 


Leu Gly Ala Glu Ser Ala Pro Pro Gly Gln Gln Ala Pro Pro Asn Thr 
                805                 810                 815     


Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln 
            820                 825                 830         


Asn Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu 
        835                 840                 845             


Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly 
    850                 855                 860                 


Ser Ser Thr Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg 
865                 870                 875                 880 


Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn 
                885                 890                 895     


Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys 
            900                 905                 910         


Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser 
        915                 920                 925             


Gly Lys Lys Glu Lys Lys 
    930                 


<210>  5293
<211>  938
<212>  PRT
<213>  Homo sapiens

<400>  5293

Met Leu Arg Lys Val Arg Ser Trp Thr Glu Ile Trp Arg Trp Ala Thr 
1               5                   10                  15      


Leu Leu Phe Leu Phe Tyr His Leu Gly Tyr Val Cys Gly Gln Ile Arg 
            20                  25                  30          


Tyr Pro Val Pro Glu Glu Ser Gln Glu Gly Thr Phe Val Gly Asn Val 
        35                  40                  45              


Ala Gln Asp Phe Leu Leu Asp Thr Asp Ser Leu Ser Ala Arg Arg Leu 
    50                  55                  60                  


Gln Val Ala Gly Glu Val Asn Gln Arg His Phe Arg Val Asp Leu Asp 
65                  70                  75                  80  


Ser Gly Ala Leu Leu Ile Lys Asn Pro Ile Asp Arg Glu Ala Leu Cys 
                85                  90                  95      


Gly Leu Ser Ala Ser Cys Ile Val Pro Leu Glu Phe Val Thr Glu Gly 
            100                 105                 110         


Pro Leu Glu Met Tyr Arg Ala Glu Val Glu Ile Val Asp Val Asn Asp 
        115                 120                 125             


His Ala Pro Arg Phe Pro Arg Gln Gln Leu Asp Leu Glu Ile Gly Glu 
    130                 135                 140                 


Ala Ala Pro Pro Gly Gln Arg Phe Pro Leu Glu Lys Ala Gln Asp Ala 
145                 150                 155                 160 


Asp Val Gly Ser Asn Ser Ile Ser Ser Tyr Arg Leu Ser Ser Asn Glu 
                165                 170                 175     


His Phe Ala Leu Asp Val Lys Lys Arg Ser Asp Gly Ser Leu Val Pro 
            180                 185                 190         


Glu Leu Leu Leu Glu Lys Pro Leu Asp Arg Glu Lys Gln Ser Asp Tyr 
        195                 200                 205             


Arg Leu Val Leu Thr Ala Val Asp Gly Gly Asn Pro Pro Arg Ser Gly 
    210                 215                 220                 


Thr Ala Glu Leu Arg Val Ser Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Ala Phe Gln Gln Ser Ser Tyr Arg Ile Ser Val Leu Glu Ser Ala Pro 
                245                 250                 255     


Ala Gly Met Val Leu Ile Gln Leu Asn Ala Ser Asp Pro Asp Leu Gly 
            260                 265                 270         


Pro Ser Gly Asn Val Thr Phe Tyr Phe Ser Gly His Thr Pro Asp Arg 
        275                 280                 285             


Val Arg Asn Leu Phe Ser Leu His Pro Thr Thr Gly Lys Leu Thr Leu 
    290                 295                 300                 


Leu Gly Pro Leu Asp Phe Glu Ser Glu Asn Tyr Tyr Glu Phe Asp Val 
305                 310                 315                 320 


Arg Ala Arg Asp Gly Gly Ser Pro Ala Met Glu Gln His Cys Ser Leu 
                325                 330                 335     


Arg Val Asp Leu Leu Asp Val Asn Asp Asn Ala Pro Tyr Ile Thr Val 
            340                 345                 350         


Thr Ser Glu Leu Gly Thr Leu Pro Glu Ser Ala Glu Pro Gly Thr Val 
        355                 360                 365             


Val Ala Leu Ile Ser Val Gln Asp Pro Asp Ser Gly Ser Asn Gly Asp 
    370                 375                 380                 


Val Ser Leu Arg Ile Pro Asp His Leu Pro Phe Ala Leu Lys Ser Ala 
385                 390                 395                 400 


Phe Arg Asn Gln Phe Ser Leu Val Thr Ala Gly Pro Leu Asp Arg Glu 
                405                 410                 415     


Ala Lys Ser Ser Tyr Asp Ile Met Val Thr Ala Ser Asp Ala Gly Asn 
            420                 425                 430         


Pro Pro Leu Ser Thr His Arg Thr Ile Phe Leu Asn Ile Ser Asp Val 
        435                 440                 445             


Asn Asp Asn Pro Pro Ser Phe Phe Gln Arg Ser His Glu Val Phe Val 
    450                 455                 460                 


Pro Glu Asn Asn Arg Pro Gly Asp Leu Leu Cys Ser Leu Ala Ala Ser 
465                 470                 475                 480 


Asp Pro Asp Ser Gly Leu Asn Ala Leu Ile Ser Tyr Ser Leu Leu Glu 
                485                 490                 495     


Pro Arg Asn Arg Asp Val Ser Ala Ser Ser Phe Ile Ser Leu Asn Pro 
            500                 505                 510         


Gln Thr Gly Ala Val His Ala Thr Arg Ser Phe Asp Tyr Glu Gln Thr 
        515                 520                 525             


Gln Thr Leu Gln Phe Glu Val Gln Ala Arg Asp Arg Gly Asn Pro Pro 
    530                 535                 540                 


Leu Ser Ser Thr Val Thr Val Arg Leu Phe Val Leu Asp Leu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Val Leu Arg Pro Arg Ala Arg Pro Gly Ser Leu Cys 
                565                 570                 575     


Pro Gln Ala Leu Pro Pro Ser Val Gly Ala Gly His Leu Ile Thr Lys 
            580                 585                 590         


Val Thr Ala Val Asp Leu Asp Ser Gly Tyr Asn Ala Trp Val Ser Tyr 
        595                 600                 605             


Gln Leu Leu Glu Ala Pro Asp Pro Ser Leu Phe Ala Val Ser Arg Tyr 
    610                 615                 620                 


Ala Gly Glu Val Arg Thr Ala Val Pro Ile Pro Ala Asp Leu Pro Pro 
625                 630                 635                 640 


Gln Lys Leu Val Ile Val Val Lys Asp Ser Gly Ser Pro Pro Leu Ser 
                645                 650                 655     


Thr Ser Val Thr Leu Leu Val Ser Leu Glu Glu Asp Thr His Pro Val 
            660                 665                 670         


Val Pro Asp Leu Arg Glu Ser Ser Ala Pro Arg Glu Gly Glu Ser Arg 
        675                 680                 685             


Leu Thr Leu Tyr Leu Ala Val Ser Leu Val Ala Ile Cys Phe Val Ser 
    690                 695                 700                 


Phe Gly Ser Phe Val Ala Leu Leu Ser Lys Cys Leu Arg Gly Ala Ala 
705                 710                 715                 720 


Cys Gly Val Thr Cys Phe Pro Ala Gly Thr Cys Ala Cys Leu Thr Arg 
                725                 730                 735     


Ser Arg Arg Arg Glu Gly Leu Pro Pro Ser Asn Gly Ile Leu Arg Ile 
            740                 745                 750         


Gln Leu Gly Ser Asp Asp Pro Ile Lys Phe Val Asp Val Gly Gly His 
        755                 760                 765             


Ser His Gly Cys Thr Pro Leu Ala Ser Ala Pro Thr Arg Ser Asp Ser 
    770                 775                 780                 


Phe Met Met Val Lys Ser Pro Ser Ala Pro Met Ala Gly Glu Pro Val 
785                 790                 795                 800 


Arg Pro Ser Cys Pro Pro Ser Asp Leu Leu Tyr Gly Leu Glu Gln Ala 
                805                 810                 815     


Pro Pro Asn Thr Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr 
            820                 825                 830         


Ser Gly Ser Gln Asn Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln 
        835                 840                 845             


Phe Asp Thr Glu Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser Glu 
    850                 855                 860                 


Ala Ala Asp Gly Ser Ser Thr Leu Gly Gly Gly Ala Gly Thr Met Gly 
865                 870                 875                 880 


Leu Ser Ala Arg Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro Asp 
                885                 890                 895     


Tyr Arg Gln Asn Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn 
            900                 905                 910         


Ala Ala Gly Lys Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn 
        915                 920                 925             


Lys Lys Lys Ser Gly Lys Lys Glu Lys Lys 
    930                 935             


<210>  5294
<211>  878
<212>  PRT
<213>  Homo sapiens

<400>  5294

Met Gly Pro Lys Thr Leu Pro Gln Leu Ala Gly Lys Trp Gln Val Leu 
1               5                   10                  15      


Cys Met Leu Ser Leu Cys Cys Trp Gly Trp Val Ser Gly Gln Leu Arg 
            20                  25                  30          


Tyr Ser Val Val Glu Glu Ser Glu Pro Gly Thr Leu Val Gly Asn Val 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Lys Met Thr Asp Leu Leu Ser Arg Arg Leu 
    50                  55                  60                  


Gln Leu Gly Ser Glu Glu Asn Gly Arg Tyr Phe Ser Leu Ser Leu Met 
65                  70                  75                  80  


Ser Gly Ala Leu Ala Val Asn Gln Lys Ile Asp Arg Glu Ser Leu Cys 
                85                  90                  95      


Gly Ala Ser Thr Ser Cys Leu Leu Pro Val Gln Val Val Thr Glu His 
            100                 105                 110         


Pro Leu Glu Leu Ile Arg Val Glu Val Glu Ile Leu Asp Leu Asn Asp 
        115                 120                 125             


Asn Ser Pro Ser Phe Ala Thr Pro Glu Arg Glu Met Arg Ile Ser Glu 
    130                 135                 140                 


Ser Ala Ala Ser Gly Ala Arg Phe Pro Leu Asp Ser Ala Gln Asp Pro 
145                 150                 155                 160 


Asp Val Gly Thr Asn Thr Val Ser Phe Tyr Thr Leu Ser Pro Asn Ser 
                165                 170                 175     


His Phe Ser Leu Asn Val Lys Thr Leu Lys Asp Gly Lys Pro Phe Pro 
            180                 185                 190         


Glu Leu Val Leu Glu Gln Gln Leu Asp Arg Glu Ala Gln Ala Arg His 
        195                 200                 205             


Gln Leu Val Leu Thr Ala Val Asp Gly Gly Thr Pro Ala Arg Ser Gly 
    210                 215                 220                 


Thr Thr Leu Ile Ser Val Ile Val Leu Asp Ile Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Thr Phe Gln Ser Ser Val Leu Arg Val Gly Ile Pro Glu Asn Ala Pro 
                245                 250                 255     


Ile Gly Thr Leu Leu Leu Arg Leu Asn Ala Thr Asp Pro Asp Glu Gly 
            260                 265                 270         


Thr Asn Gly Gln Leu Asp Tyr Ser Phe Gly Asp His Thr Ser Glu Ala 
        275                 280                 285             


Val Arg Asn Leu Phe Gly Leu Asp Pro Ser Ser Gly Ala Ile His Val 
    290                 295                 300                 


Leu Gly Pro Ile Asp Phe Glu Glu Ser Arg Phe Tyr Glu Ile His Ala 
305                 310                 315                 320 


Arg Ala Arg Asp Gln Gly Gln Pro Ala Met Glu Gly His Cys Val Ile 
                325                 330                 335     


Gln Val Asp Val Gly Asp Val Asn Asp Asn Ala Pro Glu Val Leu Leu 
            340                 345                 350         


Ala Ser Leu Ala Asn Pro Val Leu Glu Ser Thr Pro Val Gly Thr Val 
        355                 360                 365             


Val Gly Leu Phe Asn Val Arg Asp Arg Asp Ser Gly Arg Asn Gly Glu 
    370                 375                 380                 


Val Ser Leu Asp Ile Ser Pro Asp Leu Pro Phe Gln Ile Lys Pro Ser 
385                 390                 395                 400 


Glu Asn His Tyr Ser Leu Leu Thr Ser Gln Pro Leu Asp Arg Glu Ala 
                405                 410                 415     


Thr Ser His Tyr Ile Ile Glu Leu Leu Ala Ser Asp Ala Gly Ser Pro 
            420                 425                 430         


Ser Leu His Lys His Leu Thr Ile Arg Leu Asn Ile Ser Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Arg Phe Asn Gln Gln Leu Tyr Thr Ala Tyr Ile Leu 
    450                 455                 460                 


Glu Asn Arg Pro Pro Gly Ser Leu Leu Cys Thr Val Ala Ala Ser Asp 
465                 470                 475                 480 


Pro Asp Thr Gly Asp Asn Ala Arg Leu Thr Tyr Ser Ile Val Gly Asn 
                485                 490                 495     


Gln Val Gln Gly Ala Pro Ala Ser Ser Phe Val Tyr Val Asn Pro Glu 
            500                 505                 510         


Asp Gly Arg Ile Phe Ala Gln Arg Thr Phe Asp Tyr Glu Leu Leu Gln 
        515                 520                 525             


Met Leu Gln Ile Val Val Gly Val Arg Asp Ser Gly Ser Pro Pro Leu 
    530                 535                 540                 


His Ala Asn Thr Ser Leu His Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Val Leu His Pro Arg Pro Asp Trp Glu His Ser Ala Pro 
                565                 570                 575     


Gln Arg Leu Pro Arg Ser Ala Pro Pro Gly Ser Leu Val Thr Lys Val 
            580                 585                 590         


Thr Ala Val Asp Ala Asp Ala Gly His Asn Ala Trp Leu Ser Tyr Ser 
        595                 600                 605             


Leu Leu Pro Gln Ser Thr Ala Pro Gly Leu Phe Leu Val Ser Thr His 
    610                 615                 620                 


Thr Gly Glu Val Arg Thr Ala Arg Ala Leu Leu Glu Asp Asp Ser Asp 
625                 630                 635                 640 


Thr Gln Gln Val Val Val Leu Val Arg Asp Asn Gly Asp Pro Ser Leu 
                645                 650                 655     


Ser Ser Thr Ala Thr Val Leu Leu Val Leu Glu Asp Glu Asp Pro Glu 
            660                 665                 670         


Glu Met Pro Lys Ser Ser Asp Phe Leu Ile His Pro Pro Glu Arg Ser 
        675                 680                 685             


Asp Leu Thr Leu Tyr Leu Ile Val Ala Leu Ala Thr Val Ser Leu Leu 
    690                 695                 700                 


Ser Leu Val Thr Phe Thr Phe Leu Ser Ala Lys Cys Leu Gln Gly Asn 
705                 710                 715                 720 


Ala Asp Gly Asp Gly Gly Gly Gly Gln Cys Cys Arg Arg Gln Asp Ser 
                725                 730                 735     


Pro Ser Pro Asp Phe Tyr Lys Gln Ser Ser Pro Asn Leu Gln Val Ser 
            740                 745                 750         


Ser Asp Gly Thr Leu Lys Tyr Met Glu Val Thr Leu Arg Pro Thr Asp 
        755                 760                 765             


Ser Gln Ser His Cys Tyr Arg Thr Cys Phe Ser Pro Ala Ser Asp Gly 
    770                 775                 780                 


Ser Asp Phe Thr Phe Leu Arg Pro Leu Ser Val Gln Gln Pro Thr Ala 
785                 790                 795                 800 


Leu Ala Leu Glu Pro Asp Ala Ile Arg Ser Arg Ser Asn Thr Leu Arg 
                805                 810                 815     


Glu Arg Ser Gln Val Arg Gly Ser Ala Pro Pro Arg Ala Thr Pro Gly 
            820                 825                 830         


Gly Gly Thr Gly Glu Ala Ala Arg Pro His Lys Gly Leu Asn Leu His 
        835                 840                 845             


Pro Leu Leu Ser Gly Arg Leu Gly Arg Trp Leu Arg Ser Thr Arg Phe 
    850                 855                 860                 


Ser Gly Ser Leu Asp Arg Leu Arg Glu Thr Arg Val Ala Asp 
865                 870                 875             


<210>  5295
<211>  818
<212>  PRT
<213>  Homo sapiens

<400>  5295

Met Gly Ser Gly Ala Gly Glu Leu Gly Arg Ala Glu Arg Leu Pro Val 
1               5                   10                  15      


Leu Phe Leu Phe Leu Leu Ser Leu Phe Cys Pro Ala Leu Cys Glu Gln 
            20                  25                  30          


Ile Arg Tyr Arg Ile Pro Glu Glu Met Pro Lys Gly Ser Val Val Gly 
        35                  40                  45              


Asn Leu Ala Thr Asp Leu Gly Phe Ser Val Gln Glu Leu Pro Thr Arg 
    50                  55                  60                  


Lys Leu Arg Val Ser Ser Glu Lys Pro Tyr Phe Thr Val Ser Ala Glu 
65                  70                  75                  80  


Ser Gly Glu Leu Leu Val Ser Ser Arg Leu Asp Arg Glu Glu Ile Cys 
                85                  90                  95      


Gly Lys Lys Pro Ala Cys Ala Leu Glu Phe Glu Ala Val Ala Glu Asn 
            100                 105                 110         


Pro Leu Asn Phe Tyr His Val Asn Val Glu Ile Glu Asp Ile Asn Asp 
        115                 120                 125             


His Thr Pro Lys Phe Thr Gln Asn Ser Phe Glu Leu Gln Ile Ser Glu 
    130                 135                 140                 


Ser Ala Gln Pro Gly Thr Arg Phe Ile Leu Glu Val Ala Glu Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Leu Asn Ser Leu Gln Lys Tyr Lys Leu Ser Leu Asn Pro 
                165                 170                 175     


Ser Phe Ser Leu Ile Ile Lys Glu Lys Gln Asp Gly Ser Lys Tyr Pro 
            180                 185                 190         


Glu Leu Ala Leu Glu Lys Thr Leu Asp Arg Glu Gln Gln Ser Tyr His 
        195                 200                 205             


Arg Leu Val Leu Thr Ala Leu Asp Gly Gly His Pro Pro Leu Ser Gly 
    210                 215                 220                 


Thr Thr Glu Leu Arg Ile Gln Val Thr Asp Ala Asn Asp Asn Pro Pro 
225                 230                 235                 240 


Val Phe Asn Arg Asp Val Tyr Arg Val Ser Leu Arg Glu Asn Val Pro 
                245                 250                 255     


Pro Gly Thr Thr Val Leu Gln Val Ser Ala Thr Asp Gln Asp Glu Gly 
            260                 265                 270         


Ile Asn Ser Glu Ile Thr Tyr Ser Phe Tyr Arg Thr Gly Gln Ile Phe 
        275                 280                 285             


Ser Leu Asn Ser Lys Ser Gly Glu Ile Thr Thr Gln Lys Lys Leu Asp 
    290                 295                 300                 


Phe Glu Glu Thr Lys Glu Tyr Ser Met Val Val Glu Gly Arg Asp Gly 
305                 310                 315                 320 


Gly Gly Leu Val Ala Gln Cys Thr Val Glu Ile Asn Ile Gln Asp Glu 
                325                 330                 335     


Asn Asp Asn Ser Pro Glu Val Thr Phe His Ser Leu Leu Glu Met Ile 
            340                 345                 350         


Leu Glu Asn Ala Val Pro Gly Thr Leu Ile Ala Leu Ile Lys Ile His 
        355                 360                 365             


Asp Gln Asp Ser Gly Glu Asn Gly Glu Val Asn Cys Gln Leu Gln Gly 
    370                 375                 380                 


Glu Val Pro Phe Lys Ile Ile Ser Ser Ser Lys Asn Ser Tyr Lys Leu 
385                 390                 395                 400 


Val Thr Asp Gly Thr Leu Asp Arg Glu Gln Thr Pro Glu Tyr Asn Val 
                405                 410                 415     


Thr Ile Thr Ala Thr Asp Arg Gly Lys Pro Pro Leu Ser Ser Ser Ile 
            420                 425                 430         


Ser Val Ile Leu His Ile Arg Asp Val Asn Asp Asn Ala Pro Val Phe 
        435                 440                 445             


His Gln Ala Ser Tyr Leu Val Ser Val Pro Glu Asn Asn Pro Pro Gly 
    450                 455                 460                 


Ala Ser Ile Ala Gln Val Cys Ala Ser Asp Leu Asp Leu Gly Leu Asn 
465                 470                 475                 480 


Gly Gln Val Ser Tyr Ser Ile Met Ala Ser Asp Leu Glu Pro Leu Ala 
                485                 490                 495     


Leu Ala Ser Tyr Val Ser Met Ser Ala Gln Ser Gly Val Val Phe Ala 
            500                 505                 510         


Gln Arg Ala Phe Asp Tyr Glu Gln Leu Arg Thr Phe Glu Leu Thr Leu 
        515                 520                 525             


Gln Ala Arg Asp Gln Gly Ser Pro Ala Leu Ser Ala Asn Val Ser Leu 
    530                 535                 540                 


Arg Val Leu Val Gly Asp Arg Asn Asp Asn Ala Pro Arg Val Leu Tyr 
545                 550                 555                 560 


Pro Ala Leu Gly Pro Asp Gly Ser Ala Leu Phe Asp Met Val Pro Arg 
                565                 570                 575     


Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val Asp Ala 
            580                 585                 590         


Asp Ser Gly His Asn Ala Trp Leu Ser Tyr His Val Leu Gln Ala Ser 
        595                 600                 605             


Glu Pro Gly Leu Phe Ser Leu Gly Leu Arg Thr Gly Glu Val Arg Thr 
    610                 615                 620                 


Ala Arg Ala Leu Gly Asp Arg Asp Ala Ala Arg Gln Arg Leu Leu Val 
625                 630                 635                 640 


Ala Val Arg Asp Gly Gly Gln Pro Pro Leu Ser Ala Thr Ala Thr Leu 
                645                 650                 655     


His Leu Val Phe Ala Asp Ser Leu Gln Glu Val Leu Pro Asp Ile Thr 
            660                 665                 670         


Asp Arg Pro Val Pro Ser Asp Pro Gln Ala Glu Leu Gln Phe Tyr Leu 
        675                 680                 685             


Val Val Ala Leu Ala Leu Ile Ser Val Leu Phe Leu Leu Ala Val Ile 
    690                 695                 700                 


Leu Ala Val Ala Leu Arg Leu Arg Arg Ser Ser Ser Pro Ala Ala Trp 
705                 710                 715                 720 


Ser Cys Phe Gln Pro Gly Leu Cys Val Lys Ser Gly Pro Val Val Pro 
                725                 730                 735     


Pro Asn Tyr Ser Gln Gly Thr Leu Pro Tyr Ser Tyr Asn Leu Cys Val 
            740                 745                 750         


Ala His Thr Gly Lys Thr Glu Phe Asn Phe Leu Lys Cys Ser Glu Gln 
        755                 760                 765             


Leu Ser Ser Gly Gln Asp Ile Leu Cys Gly Asp Ser Ser Gly Ala Leu 
    770                 775                 780                 


Phe Pro Leu Cys Asn Ser Ser Glu Ser Thr Ser His Pro Glu Leu Val 
785                 790                 795                 800 


Ser Phe Ile Tyr Val Tyr Ser Phe Ser Leu Pro Thr Gln Phe Ser Val 
                805                 810                 815     


Phe Thr 
        


<210>  5296
<211>  820
<212>  PRT
<213>  Homo sapiens

<400>  5296

Met Gly Gly Ser Cys Ala Gln Arg Arg Arg Ala Gly Pro Arg Gln Val 
1               5                   10                  15      


Leu Phe Pro Leu Leu Leu Pro Leu Phe Tyr Pro Thr Leu Ser Glu Pro 
            20                  25                  30          


Ile Arg Tyr Ser Ile Pro Glu Glu Leu Ala Lys Gly Ser Val Val Gly 
        35                  40                  45              


Asn Leu Ala Lys Asp Leu Gly Leu Ser Val Leu Asp Val Ser Ala Arg 
    50                  55                  60                  


Lys Leu Arg Val Ser Ala Glu Lys Leu His Phe Ser Val Asp Ala Glu 
65                  70                  75                  80  


Ser Gly Asp Leu Leu Val Lys Asn Arg Ile Asp Arg Glu Gln Ile Cys 
                85                  90                  95      


Lys Glu Arg Arg Arg Cys Glu Leu Gln Leu Glu Ala Val Val Glu Asn 
            100                 105                 110         


Pro Leu Asn Ile Phe His Val Ile Val Val Ile Glu Asp Val Asn Asp 
        115                 120                 125             


His Ala Pro Gln Phe Asp Lys Lys Glu Ile His Leu Glu Ile Phe Glu 
    130                 135                 140                 


Ser Ala Ser Ala Gly Thr Arg Leu Ser Leu Asp Pro Ala Thr Asp Pro 
145                 150                 155                 160 


Asp Ile Asn Ile Asn Ser Ile Lys Asp Tyr Lys Ile Asn Ser Asn Pro 
                165                 170                 175     


Tyr Phe Ser Leu Met Val Arg Val Asn Ser Asp Gly Gly Lys Tyr Pro 
            180                 185                 190         


Glu Leu Ser Leu Glu Lys Leu Leu Asp Arg Glu Glu Gln Arg Ser His 
        195                 200                 205             


Ser Leu Ile Leu Thr Ala Leu Asp Gly Gly Asp Pro Pro Arg Ser Ala 
    210                 215                 220                 


Thr Ala His Ile Glu Ile Ser Val Lys Asp Thr Asn Asp Asn Pro Pro 
225                 230                 235                 240 


Val Phe Ser Arg Asp Glu Tyr Arg Ile Ser Leu Ser Glu Asn Leu Pro 
                245                 250                 255     


Pro Gly Ser Pro Val Leu Gln Val Thr Ala Thr Asp Gln Asp Glu Gly 
            260                 265                 270         


Val Asn Ala Glu Ile Asn Tyr Tyr Phe Arg Ser Thr Ala Gln Ser Thr 
        275                 280                 285             


Lys His Met Phe Ser Leu Asp Glu Lys Thr Gly Met Ile Lys Asn Asn 
    290                 295                 300                 


Gln Ser Phe Asp Phe Glu Asp Val Glu Arg Tyr Thr Met Glu Val Glu 
305                 310                 315                 320 


Ala Lys Asp Gly Gly Gly Leu Ser Thr Gln Cys Lys Val Ile Ile Glu 
                325                 330                 335     


Ile Leu Asp Glu Asn Asp Asn Ser Pro Glu Ile Ile Ile Thr Ser Leu 
            340                 345                 350         


Ser Asp Gln Ile Leu Glu Asn Ser Pro Pro Gly Met Val Val Ala Leu 
        355                 360                 365             


Phe Lys Thr Arg Asp Leu Asp Phe Gly Gly Asn Gly Glu Val Arg Cys 
    370                 375                 380                 


Asn Ile Glu Thr Asp Ile Pro Phe Lys Ile Tyr Ser Ser Ser Asn Asn 
385                 390                 395                 400 


Tyr Tyr Lys Leu Val Thr Asp Gly Ala Leu Asp Arg Glu Gln Thr Pro 
                405                 410                 415     


Glu Tyr Asn Val Thr Ile Val Ala Thr Asp Arg Gly Lys Pro Pro Leu 
            420                 425                 430         


Ser Ser Ser Arg Ser Ile Thr Leu Tyr Val Ala Asp Ile Asn Asp Asn 
        435                 440                 445             


Ala Pro Val Phe Asp Gln Thr Ser Tyr Val Val His Val Ala Glu Asn 
    450                 455                 460                 


Asn Pro Pro Gly Ala Ser Ile Ala Gln Val Ser Ala Ser Asp Pro Asp 
465                 470                 475                 480 


Leu Gly Leu Asn Gly His Ile Ser Tyr Ser Ile Val Ala Ser Asp Leu 
                485                 490                 495     


Glu Pro Leu Ala Val Ser Ser Tyr Val Ser Val Ser Ala Gln Ser Gly 
            500                 505                 510         


Val Val Phe Ala Gln Arg Ala Phe Asp His Glu Gln Leu Arg Ala Phe 
        515                 520                 525             


Ala Leu Thr Leu Gln Ala Arg Asp His Gly Ser Pro Thr Leu Ser Ala 
    530                 535                 540                 


Asn Val Ser Leu Arg Val Leu Val Gly Asp Arg Asn Asp Asn Ala Pro 
545                 550                 555                 560 


Arg Val Leu Tyr Pro Ala Leu Gly Pro Asp Gly Ser Ala Phe Phe Asp 
                565                 570                 575     


Met Val Pro Arg Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val 
            580                 585                 590         


Ala Val Asp Ala Asp Ser Gly His Asn Ala Trp Leu Ser Tyr His Val 
        595                 600                 605             


Leu Gln Ala Ser Glu Pro Gly Leu Phe Ser Leu Gly Leu Arg Thr Gly 
    610                 615                 620                 


Glu Val Arg Thr Ala Arg Ala Leu Gly Asp Arg Asp Ala Ala Arg Gln 
625                 630                 635                 640 


Arg Leu Leu Val Ala Val Arg Asp Gly Gly Gln Pro Pro Leu Ser Ala 
                645                 650                 655     


Thr Ala Thr Leu His Leu Val Phe Ala Asp Asn Leu Gln Glu Ile Leu 
            660                 665                 670         


Pro Asp Leu Ser Asp Arg Pro Val Leu Ser Asp Pro Gln Ala Glu Leu 
        675                 680                 685             


Gln Phe Tyr Leu Val Val Ala Leu Ala Leu Ile Ser Val Leu Phe Leu 
    690                 695                 700                 


Leu Ala Val Ile Leu Ala Ile Ala Leu Arg Leu Arg Arg Ser Leu Ser 
705                 710                 715                 720 


Pro Ala Thr Trp Asp Cys Phe His Pro Gly Leu Cys Val Lys Ser Gly 
                725                 730                 735     


Pro Val Val Pro Pro Asn Tyr Ser Glu Gly Thr Leu Pro Tyr Ser Tyr 
            740                 745                 750         


Asn Leu Cys Ile Ala His Thr Gly Thr Lys Glu Phe Asn Phe Leu Lys 
        755                 760                 765             


Cys Ser Val Pro Leu His Ser Asn Glu Asp Met Val Cys Ser Val Ser 
    770                 775                 780                 


Pro Gly Ala Leu Ile Pro Pro His Gly Gly Glu Asp Leu Thr Ser His 
785                 790                 795                 800 


Pro Glu Thr Leu Thr Ser Val Ser Phe Ser Phe Leu Cys Val Ile Tyr 
                805                 810                 815     


Leu Ile Val Tyr 
            820 


<210>  5297
<211>  888
<212>  PRT
<213>  Homo sapiens

<400>  5297

Met Gln Thr Pro Arg Ala Ser Pro Pro Arg Pro Ala Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Gly Gly Ala His Gly Leu Phe Pro Glu Glu Pro Pro 
            20                  25                  30          


Pro Leu Ser Val Ala Pro Arg Asp Tyr Leu Asn His Tyr Pro Val Phe 
        35                  40                  45              


Val Gly Ser Gly Pro Gly Arg Leu Thr Pro Ala Glu Gly Ala Asp Asp 
    50                  55                  60                  


Leu Asn Ile Gln Arg Val Leu Arg Val Asn Arg Thr Leu Phe Ile Gly 
65                  70                  75                  80  


Asp Arg Asp Asn Leu Tyr Arg Val Glu Leu Glu Pro Pro Thr Ser Thr 
                85                  90                  95      


Glu Leu Arg Tyr Gln Arg Lys Leu Thr Trp Arg Ser Asn Pro Ser Asp 
            100                 105                 110         


Ile Asn Val Cys Arg Met Lys Gly Lys Gln Glu Gly Glu Cys Arg Asn 
        115                 120                 125             


Phe Val Lys Val Leu Leu Leu Arg Asp Glu Ser Thr Leu Phe Val Cys 
    130                 135                 140                 


Gly Ser Asn Ala Phe Asn Pro Val Cys Ala Asn Tyr Ser Ile Asp Thr 
145                 150                 155                 160 


Leu Gln Pro Val Gly Asp Asn Ile Ser Gly Met Ala Arg Cys Pro Tyr 
                165                 170                 175     


Asp Pro Lys His Ala Asn Val Ala Leu Phe Ser Asp Gly Met Leu Phe 
            180                 185                 190         


Thr Ala Thr Val Thr Asp Phe Leu Ala Ile Asp Ala Val Ile Tyr Arg 
        195                 200                 205             


Ser Leu Gly Asp Arg Pro Thr Leu Arg Thr Val Lys His Asp Ser Lys 
    210                 215                 220                 


Trp Phe Lys Glu Pro Tyr Phe Val His Ala Val Glu Trp Gly Ser His 
225                 230                 235                 240 


Val Tyr Phe Phe Phe Arg Glu Ile Ala Met Glu Phe Asn Tyr Leu Glu 
                245                 250                 255     


Lys Val Val Val Ser Arg Val Ala Arg Val Cys Lys Asn Asp Val Gly 
            260                 265                 270         


Gly Ser Pro Arg Val Leu Glu Lys Gln Trp Thr Ser Phe Leu Lys Ala 
        275                 280                 285             


Arg Leu Asn Cys Ser Val Pro Gly Asp Ser His Phe Tyr Phe Asn Val 
    290                 295                 300                 


Leu Gln Ala Val Thr Gly Val Val Ser Leu Gly Gly Arg Pro Val Val 
305                 310                 315                 320 


Leu Ala Val Phe Ser Thr Pro Ser Asn Ser Ile Pro Gly Ser Ala Val 
                325                 330                 335     


Cys Ala Phe Asp Leu Thr Gln Val Ala Ala Val Phe Glu Gly Arg Phe 
            340                 345                 350         


Arg Glu Gln Lys Ser Pro Glu Ser Ile Trp Thr Pro Val Pro Glu Asp 
        355                 360                 365             


Gln Val Pro Arg Pro Arg Pro Gly Cys Cys Ala Ala Pro Gly Met Gln 
    370                 375                 380                 


Tyr Asn Ala Ser Ser Ala Leu Pro Asp Asp Ile Leu Asn Phe Val Lys 
385                 390                 395                 400 


Thr His Pro Leu Met Asp Glu Ala Val Pro Ser Leu Gly His Ala Pro 
                405                 410                 415     


Trp Ile Leu Arg Thr Leu Met Arg His Gln Leu Thr Arg Val Ala Val 
            420                 425                 430         


Asp Val Gly Ala Gly Pro Trp Gly Asn Gln Thr Val Val Phe Leu Gly 
        435                 440                 445             


Ser Glu Ala Gly Thr Val Leu Lys Phe Leu Val Arg Pro Asn Ala Ser 
    450                 455                 460                 


Thr Ser Gly Thr Ser Gly Leu Ser Val Phe Leu Glu Glu Phe Glu Thr 
465                 470                 475                 480 


Tyr Arg Pro Asp Arg Cys Gly Arg Pro Gly Gly Gly Glu Thr Gly Gln 
                485                 490                 495     


Arg Leu Leu Ser Leu Glu Leu Asp Ala Ala Ser Gly Gly Leu Leu Ala 
            500                 505                 510         


Ala Phe Pro Arg Cys Val Val Arg Val Pro Val Ala Arg Cys Gln Gln 
        515                 520                 525             


Tyr Ser Gly Cys Met Lys Asn Cys Ile Gly Ser Gln Asp Pro Tyr Cys 
    530                 535                 540                 


Gly Trp Ala Pro Asp Gly Ser Cys Ile Phe Leu Ser Pro Gly Thr Arg 
545                 550                 555                 560 


Ala Ala Phe Glu Gln Asp Val Ser Gly Ala Ser Thr Ser Gly Leu Gly 
                565                 570                 575     


Asp Cys Thr Gly Leu Leu Arg Ala Ser Leu Ser Glu Asp Arg Ala Gly 
            580                 585                 590         


Leu Val Ser Val Asn Leu Leu Val Thr Ser Ser Val Ala Ala Phe Val 
        595                 600                 605             


Val Gly Ala Val Val Ser Gly Phe Ser Val Gly Trp Phe Val Gly Leu 
    610                 615                 620                 


Arg Glu Arg Arg Glu Leu Ala Arg Arg Lys Asp Lys Glu Ala Ile Leu 
625                 630                 635                 640 


Ala His Gly Ala Gly Glu Ala Val Leu Ser Val Ser Arg Leu Gly Glu 
                645                 650                 655     


Arg Arg Ala Gln Gly Pro Gly Gly Arg Gly Gly Gly Gly Gly Gly Gly 
            660                 665                 670         


Ala Gly Val Pro Pro Glu Ala Leu Leu Ala Pro Leu Met Gln Asn Gly 
        675                 680                 685             


Trp Ala Lys Ala Thr Leu Leu Gln Gly Gly Pro His Asp Leu Asp Ser 
    690                 695                 700                 


Gly Leu Leu Pro Thr Pro Glu Gln Thr Pro Leu Pro Gln Lys Arg Leu 
705                 710                 715                 720 


Pro Thr Pro His Pro His Pro His Ala Leu Gly Pro Arg Ala Trp Asp 
                725                 730                 735     


His Gly His Pro Leu Leu Pro Ala Ser Ala Ser Ser Ser Leu Leu Leu 
            740                 745                 750         


Leu Ala Pro Ala Arg Ala Pro Glu Gln Pro Pro Ala Pro Gly Glu Pro 
        755                 760                 765             


Thr Pro Asp Gly Arg Leu Tyr Ala Ala Arg Pro Gly Arg Ala Ser His 
    770                 775                 780                 


Gly Asp Phe Pro Leu Thr Pro His Ala Ser Pro Asp Arg Arg Arg Val 
785                 790                 795                 800 


Val Ser Ala Pro Thr Gly Pro Leu Asp Pro Ala Ser Ala Ala Asp Gly 
                805                 810                 815     


Leu Pro Arg Pro Trp Ser Pro Pro Pro Thr Gly Ser Leu Arg Arg Pro 
            820                 825                 830         


Leu Gly Pro His Ala Pro Pro Ala Ala Thr Leu Arg Arg Thr His Thr 
        835                 840                 845             


Phe Asn Ser Gly Glu Ala Arg Pro Gly Asp Arg His Arg Gly Cys His 
    850                 855                 860                 


Ala Arg Pro Gly Thr Asp Leu Ala His Leu Leu Pro Tyr Gly Gly Ala 
865                 870                 875                 880 


Asp Arg Thr Ala Pro Pro Val Pro 
                885             


<210>  5298
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  5298

Met Pro Ser Ala Gly Leu Cys Ser Cys Trp Gly Gly Arg Val Leu Pro 
1               5                   10                  15      


Leu Leu Leu Ala Tyr Val Cys Tyr Leu Leu Leu Gly Ala Thr Ile Phe 
            20                  25                  30          


Gln Leu Leu Glu Arg Gln Ala Glu Ala Gln Ser Arg Asp Gln Phe Gln 
        35                  40                  45              


Leu Glu Lys Leu Arg Phe Leu Glu Asn Tyr Thr Cys Leu Asp Gln Trp 
    50                  55                  60                  


Ala Met Glu Gln Phe Val Gln Val Ile Met Glu Ala Trp Val Lys Gly 
65                  70                  75                  80  


Val Asn Pro Lys Gly Asn Ser Thr Asn Pro Ser Asn Trp Asp Phe Gly 
                85                  90                  95      


Ser Ser Phe Phe Phe Ala Gly Thr Val Val Thr Thr Ile Gly Tyr Gly 
            100                 105                 110         


Asn Leu Ala Pro Ser Thr Glu Ala Gly Gln Val Phe Cys Val Phe Tyr 
        115                 120                 125             


Ala Leu Leu Gly Ile Pro Leu Asn Val Ile Phe Leu Asn His Leu Gly 
    130                 135                 140                 


Thr Gly Leu Arg Ala His Leu Ala Ala Ile Glu Arg Trp Glu Asp Arg 
145                 150                 155                 160 


Pro Arg Arg Ser Gln Val Leu Gln Val Leu Gly Leu Ala Leu Phe Leu 
                165                 170                 175     


Thr Leu Gly Thr Leu Val Ile Leu Ile Phe Pro Pro Met Val Phe Ser 
            180                 185                 190         


His Val Glu Gly Trp Ser Phe Ser Glu Gly Phe Tyr Phe Ala Phe Ile 
        195                 200                 205             


Thr Leu Ser Thr Ile Gly Phe Gly Asp Tyr Val Val Gly Thr Asp Pro 
    210                 215                 220                 


Ser Lys His Tyr Ile Ser Val Tyr Arg Ser Leu Ala Ala Ile Trp Ile 
225                 230                 235                 240 


Leu Leu Gly Leu Ala Trp Leu Ala Leu Ile Leu Pro Leu Gly Pro Leu 
                245                 250                 255     


Leu Leu His Arg Cys Cys Gln Leu Trp Leu Leu Ser Leu Arg Gln Gly 
            260                 265                 270         


Cys Gly Ala Lys Ala Ala Pro Gly Arg Arg Pro Arg Arg Gly Ser Thr 
        275                 280                 285             


Ala Ala Arg Gly Val Gln Val Thr Pro Gln Asp Phe Pro Ile Ser Lys 
    290                 295                 300                 


Lys Gly Leu Gly Ser 
305                 


<210>  5299
<211>  6306
<212>  PRT
<213>  Homo sapiens

<400>  5299

Met Ser Val Phe Leu Gly Pro Gly Met Pro Ser Ala Ser Leu Leu Val 
1               5                   10                  15      


Asn Leu Leu Ser Ala Leu Leu Ile Leu Phe Val Phe Gly Glu Thr Glu 
            20                  25                  30          


Ile Arg Phe Thr Gly Gln Thr Glu Phe Val Val Asn Glu Thr Ser Thr 
        35                  40                  45              


Thr Val Ile Arg Leu Ile Ile Glu Arg Ile Gly Glu Pro Ala Asn Val 
    50                  55                  60                  


Thr Ala Ile Val Ser Leu Tyr Gly Glu Asp Ala Gly Asp Phe Phe Asp 
65                  70                  75                  80  


Thr Tyr Ala Ala Ala Phe Ile Pro Ala Gly Glu Thr Asn Arg Thr Val 
                85                  90                  95      


Tyr Ile Ala Val Cys Asp Asp Asp Leu Pro Glu Pro Asp Glu Thr Phe 
            100                 105                 110         


Ile Phe His Leu Thr Leu Gln Lys Pro Ser Ala Asn Val Lys Leu Gly 
        115                 120                 125             


Trp Pro Arg Thr Val Thr Val Thr Ile Leu Ser Asn Asp Asn Ala Phe 
    130                 135                 140                 


Gly Ile Ile Ser Phe Asn Met Leu Pro Ser Ile Ala Val Ser Glu Pro 
145                 150                 155                 160 


Lys Gly Arg Asn Glu Ser Met Pro Leu Thr Leu Ile Arg Glu Lys Gly 
                165                 170                 175     


Thr Tyr Gly Met Val Met Val Thr Phe Glu Val Glu Gly Gly Pro Asn 
            180                 185                 190         


Pro Pro Asp Glu Asp Leu Ser Pro Val Lys Gly Asn Ile Thr Phe Pro 
        195                 200                 205             


Pro Gly Arg Ala Thr Val Ile Tyr Asn Leu Thr Val Leu Asp Asp Glu 
    210                 215                 220                 


Val Pro Glu Asn Asp Glu Ile Phe Leu Ile Gln Leu Lys Ser Val Glu 
225                 230                 235                 240 


Gly Gly Ala Glu Ile Asn Thr Ser Arg Asn Ser Ile Glu Ile Ile Ile 
                245                 250                 255     


Lys Lys Asn Asp Ser Pro Val Arg Phe Leu Gln Ser Ile Tyr Leu Val 
            260                 265                 270         


Pro Glu Glu Asp His Ile Leu Ile Ile Pro Val Val Arg Gly Lys Asp 
        275                 280                 285             


Asn Asn Gly Asn Leu Ile Gly Ser Asp Glu Tyr Glu Val Ser Ile Ser 
    290                 295                 300                 


Tyr Ala Val Thr Thr Gly Asn Ser Thr Ala His Ala Gln Gln Asn Leu 
305                 310                 315                 320 


Asp Phe Ile Asp Leu Gln Pro Asn Thr Thr Val Val Phe Pro Pro Phe 
                325                 330                 335     


Ile His Glu Ser His Leu Lys Phe Gln Ile Val Asp Asp Thr Ile Pro 
            340                 345                 350         


Glu Ile Ala Glu Ser Phe His Ile Met Leu Leu Lys Asp Thr Leu Gln 
        355                 360                 365             


Gly Asp Ala Val Leu Ile Ser Pro Ser Val Val Gln Val Thr Ile Lys 
    370                 375                 380                 


Pro Asn Asp Lys Pro Tyr Gly Val Leu Ser Phe Asn Ser Val Leu Phe 
385                 390                 395                 400 


Glu Arg Thr Val Ile Ile Asp Glu Asp Arg Ile Ser Arg Tyr Glu Glu 
                405                 410                 415     


Ile Thr Val Val Arg Asn Gly Gly Thr His Gly Asn Val Ser Ala Asn 
            420                 425                 430         


Trp Val Leu Thr Arg Asn Ser Thr Asp Pro Ser Pro Val Thr Ala Asp 
        435                 440                 445             


Ile Arg Pro Ser Ser Gly Val Leu His Phe Ala Gln Gly Gln Met Leu 
    450                 455                 460                 


Ala Thr Ile Pro Leu Thr Val Val Asp Asp Asp Leu Pro Glu Glu Ala 
465                 470                 475                 480 


Glu Ala Tyr Leu Leu Gln Ile Leu Pro His Thr Ile Arg Gly Gly Ala 
                485                 490                 495     


Glu Val Ser Glu Pro Ala Glu Leu Leu Phe Tyr Ile Gln Asp Ser Asp 
            500                 505                 510         


Asp Val Tyr Gly Leu Ile Thr Phe Phe Pro Met Glu Asn Gln Lys Ile 
        515                 520                 525             


Glu Ser Ser Pro Gly Glu Arg Tyr Leu Ser Leu Ser Phe Thr Arg Leu 
    530                 535                 540                 


Gly Gly Thr Lys Gly Asp Val Arg Leu Leu Tyr Ser Val Leu Tyr Ile 
545                 550                 555                 560 


Pro Ala Gly Ala Val Asp Pro Leu Gln Ala Lys Glu Gly Ile Leu Asn 
                565                 570                 575     


Ile Ser Arg Arg Asn Asp Leu Ile Phe Pro Glu Gln Lys Thr Gln Val 
            580                 585                 590         


Thr Thr Lys Leu Pro Ile Arg Asn Asp Ala Phe Leu Gln Asn Gly Ala 
        595                 600                 605             


His Phe Leu Val Gln Leu Glu Thr Val Glu Leu Leu Asn Ile Ile Pro 
    610                 615                 620                 


Leu Ile Pro Pro Ile Ser Pro Arg Phe Gly Glu Ile Cys Asn Ile Ser 
625                 630                 635                 640 


Leu Leu Val Thr Pro Ala Ile Ala Asn Gly Glu Ile Gly Phe Leu Ser 
                645                 650                 655     


Asn Leu Pro Ile Ile Leu His Glu Pro Glu Asp Phe Ala Ala Glu Val 
            660                 665                 670         


Val Tyr Ile Pro Leu His Arg Asp Gly Thr Asp Gly Gln Ala Thr Val 
        675                 680                 685             


Tyr Trp Ser Leu Lys Pro Ser Gly Phe Asn Ser Lys Ala Val Thr Pro 
    690                 695                 700                 


Asp Asp Ile Gly Pro Phe Asn Gly Ser Val Leu Phe Leu Ser Gly Gln 
705                 710                 715                 720 


Ser Asp Thr Thr Ile Asn Ile Thr Ile Lys Gly Asp Asp Ile Pro Glu 
                725                 730                 735     


Met Asn Glu Thr Val Thr Leu Ser Leu Asp Arg Val Asn Val Glu Asn 
            740                 745                 750         


Gln Val Leu Lys Ser Gly Tyr Thr Ser Arg Asp Leu Ile Ile Leu Glu 
        755                 760                 765             


Asn Asp Asp Pro Gly Gly Val Phe Glu Phe Ser Pro Ala Ser Arg Gly 
    770                 775                 780                 


Pro Tyr Val Ile Lys Glu Gly Glu Ser Val Glu Leu His Ile Ile Arg 
785                 790                 795                 800 


Ser Arg Gly Ser Leu Val Lys Gln Phe Leu His Tyr Arg Val Glu Pro 
                805                 810                 815     


Arg Asp Ser Asn Glu Phe Tyr Gly Asn Thr Gly Val Leu Glu Phe Lys 
            820                 825                 830         


Pro Gly Glu Arg Glu Ile Val Ile Thr Leu Leu Ala Arg Leu Asp Gly 
        835                 840                 845             


Ile Pro Glu Leu Asp Glu His Tyr Trp Val Val Leu Ser Ser His Gly 
    850                 855                 860                 


Glu Arg Glu Ser Lys Leu Gly Ser Ala Thr Ile Val Asn Ile Thr Ile 
865                 870                 875                 880 


Leu Lys Asn Asp Asp Pro His Gly Ile Ile Glu Phe Val Ser Asp Gly 
                885                 890                 895     


Leu Ile Val Met Ile Asn Glu Ser Lys Gly Asp Ala Ile Tyr Ser Ala 
            900                 905                 910         


Val Tyr Asp Val Val Arg Asn Arg Gly Asn Phe Gly Asp Val Ser Val 
        915                 920                 925             


Ser Trp Val Val Ser Pro Asp Phe Thr Gln Asp Val Phe Pro Val Gln 
    930                 935                 940                 


Gly Thr Val Val Phe Gly Asp Gln Glu Phe Ser Lys Asn Ile Thr Ile 
945                 950                 955                 960 


Tyr Ser Leu Pro Asp Glu Ile Pro Glu Glu Met Glu Glu Phe Thr Val 
                965                 970                 975     


Ile Leu Leu Asn Gly Thr Gly Gly Ala Lys Val Gly Asn Arg Thr Thr 
            980                 985                 990         


Ala Thr Leu Arg Ile Arg Arg Asn  Asp Asp Pro Ile Tyr  Phe Ala Glu 
        995                 1000                 1005             


Pro Arg  Val Val Arg Val Gln  Glu Gly Glu Thr Ala  Asn Phe Thr 
    1010                 1015                 1020             


Val Leu  Arg Asn Gly Ser Val  Asp Val Thr Cys Met  Val Gln Tyr 
    1025                 1030                 1035             


Ala Thr  Lys Asp Gly Lys Ala  Thr Ala Arg Glu Arg  Asp Phe Ile 
    1040                 1045                 1050             


Pro Val  Glu Lys Gly Glu Thr  Leu Ile Phe Glu Val  Gly Ser Arg 
    1055                 1060                 1065             


Gln Gln  Ser Ile Ser Ile Phe  Val Asn Glu Asp Gly  Ile Pro Glu 
    1070                 1075                 1080             


Thr Asp  Glu Pro Phe Tyr Ile  Ile Leu Leu Asn Ser  Thr Gly Asp 
    1085                 1090                 1095             


Thr Val  Val Tyr Gln Tyr Gly  Val Ala Thr Val Ile  Ile Glu Ala 
    1100                 1105                 1110             


Asn Asp  Asp Pro Asn Gly Ile  Phe Ser Leu Glu Pro  Ile Asp Lys 
    1115                 1120                 1125             


Ala Val  Glu Glu Gly Lys Thr  Asn Ala Phe Trp Ile  Leu Arg His 
    1130                 1135                 1140             


Arg Gly  Tyr Phe Gly Ser Val  Ser Val Ser Trp Gln  Leu Phe Gln 
    1145                 1150                 1155             


Asn Asp  Ser Ala Leu Gln Pro  Gly Gln Glu Phe Tyr  Glu Thr Ser 
    1160                 1165                 1170             


Gly Thr  Val Asn Phe Met Asp  Gly Glu Glu Ala Lys  Pro Ile Ile 
    1175                 1180                 1185             


Leu His  Ala Phe Pro Asp Lys  Ile Pro Glu Phe Asn  Glu Phe Tyr 
    1190                 1195                 1200             


Phe Leu  Lys Leu Val Asn Ile  Ser Gly Gly Ser Pro  Gly Pro Gly 
    1205                 1210                 1215             


Gly Gln  Leu Ala Glu Thr Asn  Leu Gln Val Thr Val  Met Val Pro 
    1220                 1225                 1230             


Phe Asn  Asp Asp Pro Phe Gly  Val Phe Ile Leu Asp  Pro Glu Cys 
    1235                 1240                 1245             


Leu Glu  Arg Glu Val Ala Glu  Asp Val Leu Ser Glu  Asp Asp Met 
    1250                 1255                 1260             


Ser Tyr  Ile Thr Asn Phe Thr  Ile Leu Arg Gln Gln  Gly Val Phe 
    1265                 1270                 1275             


Gly Asp  Val Gln Leu Gly Trp  Glu Ile Leu Ser Ser  Glu Phe Pro 
    1280                 1285                 1290             


Ala Gly  Leu Pro Pro Met Ile  Asp Phe Leu Leu Val  Gly Ile Phe 
    1295                 1300                 1305             


Pro Thr  Thr Val His Leu Gln  Gln His Met Arg Arg  His His Ser 
    1310                 1315                 1320             


Gly Thr  Asp Ala Leu Tyr Phe  Thr Gly Leu Glu Gly  Ala Phe Gly 
    1325                 1330                 1335             


Thr Val  Asn Pro Lys Tyr His  Pro Ser Arg Asn Asn  Thr Ile Ala 
    1340                 1345                 1350             


Asn Phe  Thr Phe Ser Ala Trp  Val Met Pro Asn Ala  Asn Thr Asn 
    1355                 1360                 1365             


Gly Phe  Ile Ile Ala Lys Asp  Asp Gly Asn Gly Ser  Ile Tyr Tyr 
    1370                 1375                 1380             


Gly Val  Lys Ile Gln Thr Asn  Glu Ser His Val Thr  Leu Ser Leu 
    1385                 1390                 1395             


His Tyr  Lys Thr Leu Gly Ser  Asn Ala Thr Tyr Ile  Ala Lys Thr 
    1400                 1405                 1410             


Thr Val  Met Lys Tyr Leu Glu  Glu Ser Val Trp Leu  His Leu Leu 
    1415                 1420                 1425             


Ile Ile  Leu Glu Asp Gly Ile  Ile Glu Phe Tyr Leu  Asp Gly Asn 
    1430                 1435                 1440             


Ala Met  Pro Arg Gly Ile Lys  Ser Leu Lys Gly Glu  Ala Ile Thr 
    1445                 1450                 1455             


Asp Gly  Pro Gly Ile Leu Arg  Ile Gly Ala Gly Ile  Asn Gly Asn 
    1460                 1465                 1470             


Asp Arg  Phe Thr Gly Leu Met  Gln Asp Val Arg Ser  Tyr Glu Arg 
    1475                 1480                 1485             


Lys Leu  Thr Leu Glu Glu Ile  Tyr Glu Leu His Ala  Met Pro Ala 
    1490                 1495                 1500             


Lys Ser  Asp Leu His Pro Ile  Ser Gly Tyr Leu Glu  Phe Arg Gln 
    1505                 1510                 1515             


Gly Glu  Thr Asn Lys Ser Phe  Ile Ile Ser Ala Arg  Asp Asp Asn 
    1520                 1525                 1530             


Asp Glu  Glu Gly Glu Glu Leu  Phe Ile Leu Lys Leu  Val Ser Val 
    1535                 1540                 1545             


Tyr Gly  Gly Ala Arg Ile Ser  Glu Glu Asn Thr Thr  Ala Arg Leu 
    1550                 1555                 1560             


Thr Ile  Gln Lys Ser Asp Asn  Ala Asn Gly Leu Phe  Gly Phe Thr 
    1565                 1570                 1575             


Gly Ala  Cys Ile Pro Glu Ile  Ala Glu Glu Gly Ser  Thr Ile Ser 
    1580                 1585                 1590             


Cys Val  Val Glu Arg Thr Arg  Gly Ala Leu Asp Tyr  Val His Val 
    1595                 1600                 1605             


Phe Tyr  Thr Ile Ser Gln Ile  Glu Thr Asp Gly Ile  Asn Tyr Leu 
    1610                 1615                 1620             


Val Asp  Asp Phe Ala Asn Ala  Ser Gly Thr Ile Thr  Phe Leu Pro 
    1625                 1630                 1635             


Trp Gln  Arg Ser Glu Val Leu  Asn Ile Tyr Val Leu  Asp Asp Asp 
    1640                 1645                 1650             


Ile Pro  Glu Leu Asn Glu Tyr  Phe Arg Val Thr Leu  Val Ser Ala 
    1655                 1660                 1665             


Ile Pro  Gly Asp Gly Lys Leu  Gly Ser Thr Pro Thr  Ser Gly Ala 
    1670                 1675                 1680             


Ser Ile  Asp Pro Glu Lys Glu  Thr Thr Asp Ile Thr  Ile Lys Ala 
    1685                 1690                 1695             


Ser Asp  His Pro Tyr Gly Leu  Leu Gln Phe Ser Thr  Gly Leu Pro 
    1700                 1705                 1710             


Pro Gln  Pro Lys Asp Ala Met  Thr Leu Pro Ala Ser  Ser Val Pro 
    1715                 1720                 1725             


His Ile  Thr Val Glu Glu Glu  Asp Gly Glu Ile Arg  Leu Leu Val 
    1730                 1735                 1740             


Ile Arg  Ala Gln Gly Leu Leu  Gly Arg Val Thr Ala  Glu Phe Arg 
    1745                 1750                 1755             


Thr Val  Ser Leu Thr Ala Phe  Ser Pro Glu Asp Tyr  Gln Asn Val 
    1760                 1765                 1770             


Ala Gly  Thr Leu Glu Phe Gln  Pro Gly Glu Arg Tyr  Lys Tyr Ile 
    1775                 1780                 1785             


Phe Ile  Asn Ile Thr Asp Asn  Ser Ile Pro Glu Leu  Glu Lys Ser 
    1790                 1795                 1800             


Phe Lys  Val Glu Leu Leu Asn  Leu Glu Gly Gly Val  Ala Glu Leu 
    1805                 1810                 1815             


Phe Arg  Val Asp Gly Ser Gly  Ser Gly Asp Gly Asp  Met Glu Phe 
    1820                 1825                 1830             


Phe Leu  Pro Thr Ile His Lys  Arg Ala Ser Leu Gly  Val Ala Ser 
    1835                 1840                 1845             


Gln Ile  Leu Val Thr Ile Ala  Ala Ser Asp His Ala  His Gly Val 
    1850                 1855                 1860             


Phe Glu  Phe Ser Pro Glu Ser  Leu Phe Val Ser Gly  Thr Glu Pro 
    1865                 1870                 1875             


Glu Asp  Gly Tyr Ser Thr Val  Thr Leu Asn Val Ile  Arg His His 
    1880                 1885                 1890             


Gly Thr  Leu Ser Pro Val Thr  Leu His Trp Asn Ile  Asp Ser Asp 
    1895                 1900                 1905             


Pro Asp  Gly Asp Leu Ala Phe  Thr Ser Gly Asn Ile  Thr Phe Glu 
    1910                 1915                 1920             


Ile Gly  Gln Thr Ser Ala Asn  Ile Thr Val Glu Ile  Leu Pro Asp 
    1925                 1930                 1935             


Glu Asp  Pro Glu Leu Asp Lys  Ala Phe Ser Val Ser  Val Leu Ser 
    1940                 1945                 1950             


Val Ser  Ser Gly Ser Leu Gly  Ala His Ile Asn Ala  Thr Leu Thr 
    1955                 1960                 1965             


Val Leu  Ala Ser Asp Asp Pro  Tyr Gly Ile Phe Ile  Phe Ser Glu 
    1970                 1975                 1980             


Lys Asn  Arg Pro Val Lys Val  Glu Glu Ala Thr Gln  Asn Ile Thr 
    1985                 1990                 1995             


Leu Ser  Ile Ile Arg Leu Lys  Gly Leu Met Gly Lys  Val Leu Val 
    2000                 2005                 2010             


Ser Tyr  Ala Thr Leu Asp Asp  Met Glu Lys Pro Pro  Tyr Phe Pro 
    2015                 2020                 2025             


Pro Asn  Leu Ala Arg Ala Thr  Gln Gly Arg Asp Tyr  Ile Pro Ala 
    2030                 2035                 2040             


Ser Gly  Phe Ala Leu Phe Gly  Ala Asn Gln Ser Glu  Ala Thr Ile 
    2045                 2050                 2055             


Ala Ile  Ser Ile Leu Asp Asp  Asp Glu Pro Glu Arg  Ser Glu Ser 
    2060                 2065                 2070             


Val Phe  Ile Glu Leu Leu Asn  Ser Thr Leu Val Ala  Lys Val Gln 
    2075                 2080                 2085             


Ser Arg  Ser Ile Pro Asn Ser  Pro Arg Leu Gly Pro  Lys Val Glu 
    2090                 2095                 2100             


Thr Ile  Ala Gln Leu Ile Ile  Ile Ala Asn Asp Asp  Ala Phe Gly 
    2105                 2110                 2115             


Thr Leu  Gln Leu Ser Ala Pro  Ile Val Arg Val Ala  Glu Asn His 
    2120                 2125                 2130             


Val Gly  Pro Ile Ile Asn Val  Thr Arg Thr Gly Gly  Ala Phe Ala 
    2135                 2140                 2145             


Asp Val  Ser Val Lys Phe Lys  Ala Val Pro Ile Thr  Ala Ile Ala 
    2150                 2155                 2160             


Gly Glu  Asp Tyr Ser Ile Ala  Ser Ser Asp Val Val  Leu Leu Glu 
    2165                 2170                 2175             


Gly Glu  Thr Ser Lys Ala Val  Pro Ile Tyr Val Ile  Asn Asp Ile 
    2180                 2185                 2190             


Tyr Pro  Glu Leu Glu Glu Ser  Phe Leu Val Gln Leu  Met Asn Glu 
    2195                 2200                 2205             


Thr Thr  Gly Gly Ala Arg Leu  Gly Ala Leu Thr Glu  Ala Val Ile 
    2210                 2215                 2220             


Ile Ile  Glu Ala Ser Asp Asp  Pro Tyr Gly Leu Phe  Gly Phe Gln 
    2225                 2230                 2235             


Ile Thr  Lys Leu Ile Val Glu  Glu Pro Glu Phe Asn  Ser Val Lys 
    2240                 2245                 2250             


Val Asn  Leu Pro Ile Ile Arg  Asn Ser Gly Thr Leu  Gly Asn Val 
    2255                 2260                 2265             


Thr Val  Gln Trp Val Ala Thr  Ile Asn Gly Gln Leu  Ala Thr Gly 
    2270                 2275                 2280             


Asp Leu  Arg Val Val Ser Gly  Asn Val Thr Phe Ala  Pro Gly Glu 
    2285                 2290                 2295             


Thr Ile  Gln Thr Leu Leu Leu  Glu Val Leu Ala Asp  Asp Val Pro 
    2300                 2305                 2310             


Glu Ile  Glu Glu Val Ile Gln  Val Gln Leu Thr Asp  Ala Ser Gly 
    2315                 2320                 2325             


Gly Gly  Thr Ile Gly Leu Asp  Arg Ile Ala Asn Ile  Ile Ile Pro 
    2330                 2335                 2340             


Ala Asn  Asp Asp Pro Tyr Gly  Thr Val Ala Phe Ala  Gln Met Val 
    2345                 2350                 2355             


Tyr Arg  Val Gln Glu Pro Leu  Glu Arg Ser Ser Cys  Ala Asn Ile 
    2360                 2365                 2370             


Thr Val  Arg Arg Ser Gly Gly  His Phe Gly Arg Leu  Leu Leu Phe 
    2375                 2380                 2385             


Tyr Ser  Thr Ser Asp Ile Asp  Val Val Ala Leu Ala  Met Glu Glu 
    2390                 2395                 2400             


Gly Gln  Asp Leu Leu Ser Tyr  Tyr Glu Ser Pro Ile  Gln Gly Val 
    2405                 2410                 2415             


Pro Asp  Pro Leu Trp Arg Thr  Trp Met Asn Val Ser  Ala Val Gly 
    2420                 2425                 2430             


Glu Pro  Leu Tyr Thr Cys Ala  Thr Leu Cys Leu Lys  Glu Gln Ala 
    2435                 2440                 2445             


Cys Ser  Ala Phe Ser Phe Phe  Ser Ala Ser Glu Gly  Pro Gln Cys 
    2450                 2455                 2460             


Phe Trp  Met Thr Ser Trp Ile  Ser Pro Ala Val Asn  Asn Ser Asp 
    2465                 2470                 2475             


Phe Trp  Thr Tyr Arg Lys Asn  Met Thr Arg Val Ala  Ser Leu Phe 
    2480                 2485                 2490             


Ser Gly  Gln Ala Val Ala Gly  Ser Asp Tyr Glu Pro  Val Thr Arg 
    2495                 2500                 2505             


Gln Trp  Ala Ile Met Gln Glu  Gly Asp Glu Phe Ala  Asn Leu Thr 
    2510                 2515                 2520             


Val Ser  Ile Leu Pro Asp Asp  Phe Pro Glu Met Asp  Glu Ser Phe 
    2525                 2530                 2535             


Leu Ile  Ser Leu Leu Glu Val  His Leu Met Asn Ile  Ser Ala Ser 
    2540                 2545                 2550             


Leu Lys  Asn Gln Pro Thr Ile  Gly Gln Pro Asn Ile  Ser Thr Val 
    2555                 2560                 2565             


Val Ile  Ala Leu Asn Gly Asp  Ala Phe Gly Val Phe  Val Ile Tyr 
    2570                 2575                 2580             


Asn Ile  Ser Pro Asn Thr Ser  Glu Asp Gly Leu Phe  Val Glu Val 
    2585                 2590                 2595             


Gln Glu  Gln Pro Gln Thr Leu  Val Glu Leu Met Ile  His Arg Thr 
    2600                 2605                 2610             


Gly Gly  Ser Leu Gly Gln Val  Ala Val Glu Trp Arg  Val Val Gly 
    2615                 2620                 2625             


Gly Thr  Ala Thr Glu Gly Leu  Asp Phe Ile Gly Ala  Gly Glu Ile 
    2630                 2635                 2640             


Leu Thr  Phe Ala Glu Gly Glu  Thr Lys Lys Thr Val  Ile Leu Thr 
    2645                 2650                 2655             


Ile Leu  Asp Asp Ser Glu Pro  Glu Asp Asp Glu Ser  Ile Ile Val 
    2660                 2665                 2670             


Ser Leu  Val Tyr Thr Glu Gly  Gly Ser Arg Ile Leu  Pro Ser Ser 
    2675                 2680                 2685             


Asp Thr  Val Arg Val Asn Ile  Leu Ala Asn Asp Asn  Val Ala Gly 
    2690                 2695                 2700             


Ile Val  Ser Phe Gln Thr Ala  Ser Arg Ser Val Ile  Gly His Glu 
    2705                 2710                 2715             


Gly Glu  Ile Leu Gln Phe His  Val Ile Arg Thr Phe  Pro Gly Arg 
    2720                 2725                 2730             


Gly Asn  Val Thr Val Asn Trp  Lys Ile Ile Gly Gln  Asn Leu Glu 
    2735                 2740                 2745             


Leu Asn  Phe Ala Asn Phe Ser  Gly Gln Leu Phe Phe  Pro Glu Gly 
    2750                 2755                 2760             


Ser Leu  Asn Thr Thr Leu Phe  Val His Leu Leu Asp  Asp Asn Ile 
    2765                 2770                 2775             


Pro Glu  Glu Lys Glu Val Tyr  Gln Val Ile Leu Tyr  Asp Val Arg 
    2780                 2785                 2790             


Thr Gln  Gly Val Pro Pro Ala  Gly Ile Ala Leu Leu  Asp Ala Gln 
    2795                 2800                 2805             


Gly Tyr  Ala Ala Val Leu Thr  Val Glu Ala Ser Asp  Glu Pro His 
    2810                 2815                 2820             


Gly Val  Leu Asn Phe Ala Leu  Ser Ser Arg Phe Val  Leu Leu Gln 
    2825                 2830                 2835             


Glu Ala  Asn Ile Thr Ile Gln  Leu Phe Ile Asn Arg  Glu Phe Gly 
    2840                 2845                 2850             


Ser Leu  Gly Ala Ile Asn Val  Thr Tyr Thr Thr Val  Pro Gly Met 
    2855                 2860                 2865             


Leu Ser  Leu Lys Asn Gln Thr  Val Gly Asn Leu Ala  Glu Pro Glu 
    2870                 2875                 2880             


Val Asp  Phe Val Pro Ile Ile  Gly Phe Leu Ile Leu  Glu Glu Gly 
    2885                 2890                 2895             


Glu Thr  Ala Ala Ala Ile Asn  Ile Thr Ile Leu Glu  Asp Asp Val 
    2900                 2905                 2910             


Pro Glu  Leu Glu Glu Tyr Phe  Leu Val Asn Leu Thr  Tyr Val Gly 
    2915                 2920                 2925             


Leu Thr  Met Ala Ala Ser Thr  Ser Phe Pro Pro Arg  Leu Asp Ser 
    2930                 2935                 2940             


Glu Gly  Leu Thr Ala Gln Val  Ile Ile Asp Ala Asn  Asp Gly Ala 
    2945                 2950                 2955             


Arg Gly  Val Ile Glu Trp Gln  Gln Ser Arg Phe Glu  Val Asn Glu 
    2960                 2965                 2970             


Thr His  Gly Ser Leu Thr Leu  Val Ala Gln Arg Ser  Arg Glu Pro 
    2975                 2980                 2985             


Leu Gly  His Val Ser Leu Phe  Val Tyr Ala Gln Asn  Leu Glu Ala 
    2990                 2995                 3000             


Gln Val  Gly Leu Asp Tyr Ile  Phe Thr Pro Met Ile  Leu His Phe 
    3005                 3010                 3015             


Ala Asp  Gly Glu Arg Tyr Lys  Asn Val Asn Ile Met  Ile Leu Asp 
    3020                 3025                 3030             


Asp Asp  Ile Pro Glu Gly Asp  Glu Lys Phe Gln Leu  Ile Leu Thr 
    3035                 3040                 3045             


Asn Pro  Ser Pro Gly Leu Glu  Leu Gly Lys Asn Thr  Ile Ala Leu 
    3050                 3055                 3060             


Ile Ile  Val Leu Ala Asn Asp  Asp Gly Pro Gly Val  Leu Ser Phe 
    3065                 3070                 3075             


Asn Asn  Ser Glu His Phe Phe  Leu Arg Glu Pro Thr  Ala Leu Tyr 
    3080                 3085                 3090             


Val Gln  Glu Ser Val Ala Val  Leu Tyr Ile Val Arg  Glu Pro Ala 
    3095                 3100                 3105             


Gln Gly  Leu Phe Gly Thr Val  Thr Val Gln Phe Ile  Val Thr Glu 
    3110                 3115                 3120             


Val Asn  Ser Ser Asn Glu Ser  Lys Asp Leu Thr Pro  Ser Lys Gly 
    3125                 3130                 3135             


Tyr Ile  Val Leu Glu Glu Gly  Val Arg Phe Lys Ala  Leu Gln Ile 
    3140                 3145                 3150             


Ser Ala  Ile Leu Asp Thr Glu  Pro Glu Met Asp Glu  Tyr Phe Val 
    3155                 3160                 3165             


Cys Thr  Leu Phe Asn Pro Thr  Gly Gly Ala Arg Leu  Gly Val His 
    3170                 3175                 3180             


Val Gln  Thr Leu Ile Thr Val  Leu Gln Asn Gln Ala  Pro Leu Gly 
    3185                 3190                 3195             


Leu Phe  Ser Ile Ser Ala Val  Glu Asn Arg Ala Thr  Ser Ile Asp 
    3200                 3205                 3210             


Ile Glu  Glu Ala Asn Arg Thr  Val Tyr Leu Asn Val  Ser Arg Thr 
    3215                 3220                 3225             


Asn Gly  Ile Asp Leu Ala Val  Ser Val Gln Trp Glu  Thr Val Ser 
    3230                 3235                 3240             


Glu Thr  Ala Phe Gly Met Arg  Gly Met Asp Val Val  Phe Ser Val 
    3245                 3250                 3255             


Phe Gln  Ser Phe Leu Asp Glu  Ser Ala Ser Gly Trp  Cys Phe Phe 
    3260                 3265                 3270             


Thr Leu  Glu Asn Leu Ile Tyr  Gly Ile Met Leu Arg  Lys Ser Ser 
    3275                 3280                 3285             


Val Thr  Val Tyr Arg Trp Gln  Gly Ile Phe Ile Pro  Val Glu Asp 
    3290                 3295                 3300             


Leu Asn  Ile Glu Asn Pro Lys  Thr Cys Glu Ala Phe  Asn Ile Gly 
    3305                 3310                 3315             


Phe Ser  Pro Tyr Phe Val Ile  Thr His Glu Glu Arg  Asn Glu Glu 
    3320                 3325                 3330             


Lys Pro  Ser Leu Asn Ser Val  Phe Thr Phe Thr Ser  Gly Phe Lys 
    3335                 3340                 3345             


Leu Phe  Leu Val Gln Thr Ile  Ile Ile Leu Glu Ser  Ser Gln Val 
    3350                 3355                 3360             


Arg Tyr  Phe Thr Ser Asp Ser  Gln Asp Tyr Leu Ile  Ile Ala Ser 
    3365                 3370                 3375             


Gln Arg  Asp Asp Ser Glu Leu  Thr Gln Val Phe Arg  Trp Asn Gly 
    3380                 3385                 3390             


Gly Ser  Phe Val Leu His Gln  Lys Leu Pro Val Arg  Gly Val Leu 
    3395                 3400                 3405             


Thr Val  Ala Leu Phe Asn Lys  Gly Gly Ser Val Phe  Leu Ala Ile 
    3410                 3415                 3420             


Ser Gln  Ala Asn Ala Arg Leu  Asn Ser Leu Leu Phe  Arg Trp Ser 
    3425                 3430                 3435             


Gly Ser  Gly Phe Ile Asn Phe  Gln Glu Val Pro Val  Ser Gly Thr 
    3440                 3445                 3450             


Thr Glu  Val Glu Ala Leu Ser  Ser Ala Asn Asp Ile  Tyr Leu Ile 
    3455                 3460                 3465             


Phe Ala  Glu Asn Val Phe Leu  Gly Asp Gln Asn Ser  Ile Asp Ile 
    3470                 3475                 3480             


Phe Ile  Trp Glu Met Gly Gln  Ser Ser Phe Arg Tyr  Phe Gln Ser 
    3485                 3490                 3495             


Val Asp  Phe Ala Ala Val Asn  Arg Ile His Ser Phe  Thr Pro Ala 
    3500                 3505                 3510             


Ser Gly  Ile Ala His Ile Leu  Leu Ile Gly Gln Asp  Met Ser Ala 
    3515                 3520                 3525             


Leu Tyr  Cys Trp Asn Ser Glu  Arg Asn Gln Phe Ser  Phe Val Leu 
    3530                 3535                 3540             


Glu Val  Pro Ser Ala Tyr Asp  Val Ala Ser Val Thr  Val Lys Ser 
    3545                 3550                 3555             


Leu Asn  Ser Ser Lys Asn Leu  Ile Ala Leu Val Gly  Ala His Ser 
    3560                 3565                 3570             


His Ile  Tyr Glu Leu Ala Tyr  Ile Ser Ser His Ser  Asp Phe Ile 
    3575                 3580                 3585             


Pro Ser  Ser Gly Glu Leu Ile  Phe Glu Pro Gly Glu  Arg Glu Ala 
    3590                 3595                 3600             


Thr Ile  Ala Val Asn Ile Leu  Asp Asp Thr Val Pro  Glu Lys Glu 
    3605                 3610                 3615             


Glu Ser  Phe Lys Val Gln Leu  Lys Asn Pro Lys Gly  Gly Ala Glu 
    3620                 3625                 3630             


Ile Gly  Ile Asn Asp Ser Val  Thr Ile Thr Ile Leu  Ser Asn Asp 
    3635                 3640                 3645             


Asp Ala  Tyr Gly Ile Val Ala  Phe Ala Gln Asn Ser  Leu Tyr Lys 
    3650                 3655                 3660             


Gln Val  Glu Glu Met Glu Gln  Asp Ser Leu Val Thr  Leu Asn Val 
    3665                 3670                 3675             


Glu Arg  Leu Lys Gly Thr Tyr  Gly Arg Ile Thr Ile  Ala Trp Glu 
    3680                 3685                 3690             


Ala Asp  Gly Ser Ile Ser Asp  Ile Phe Pro Thr Ser  Gly Val Ile 
    3695                 3700                 3705             


Leu Phe  Thr Glu Gly Gln Val  Leu Ser Thr Ile Thr  Leu Thr Ile 
    3710                 3715                 3720             


Leu Ala  Asp Asn Ile Pro Glu  Leu Ser Glu Val Val  Ile Val Thr 
    3725                 3730                 3735             


Leu Thr  Arg Ile Thr Thr Glu  Gly Val Glu Asp Ser  Tyr Lys Gly 
    3740                 3745                 3750             


Ala Thr  Ile Asp Gln Asp Arg  Ser Lys Ser Val Ile  Thr Thr Leu 
    3755                 3760                 3765             


Pro Asn  Asp Ser Pro Phe Gly  Leu Val Gly Trp Arg  Ala Ala Ser 
    3770                 3775                 3780             


Val Phe  Ile Arg Val Ala Glu  Pro Lys Glu Asn Thr  Thr Thr Leu 
    3785                 3790                 3795             


Gln Leu  Gln Ile Ala Arg Asp  Lys Gly Leu Leu Gly  Asp Ile Ala 
    3800                 3805                 3810             


Ile His  Leu Arg Ala Gln Pro  Asn Phe Leu Leu His  Val Asp Asn 
    3815                 3820                 3825             


Gln Ala  Thr Glu Asn Glu Asp  Tyr Val Leu Gln Glu  Thr Ile Ile 
    3830                 3835                 3840             


Ile Met  Lys Glu Asn Ile Lys  Glu Ala His Ala Glu  Val Ser Ile 
    3845                 3850                 3855             


Leu Pro  Asp Asp Leu Pro Glu  Leu Glu Glu Gly Phe  Ile Val Thr 
    3860                 3865                 3870             


Ile Thr  Glu Val Asn Leu Val  Asn Ser Asp Phe Ser  Thr Gly Gln 
    3875                 3880                 3885             


Pro Ser  Val Arg Arg Pro Gly  Met Glu Ile Ala Glu  Ile Met Ile 
    3890                 3895                 3900             


Glu Glu  Asn Asp Asp Pro Arg  Gly Ile Phe Met Phe  His Val Thr 
    3905                 3910                 3915             


Arg Gly  Ala Gly Glu Val Ile  Thr Ala Tyr Glu Val  Pro Pro Pro 
    3920                 3925                 3930             


Leu Asn  Val Leu Gln Val Pro  Val Val Arg Leu Ala  Gly Ser Phe 
    3935                 3940                 3945             


Gly Ala  Val Asn Val Tyr Trp  Lys Ala Ser Pro Asp  Ser Ala Gly 
    3950                 3955                 3960             


Leu Glu  Asp Phe Lys Pro Ser  His Gly Ile Leu Glu  Phe Ala Asp 
    3965                 3970                 3975             


Lys Gln  Val Thr Ala Met Ile  Glu Ile Thr Ile Ile  Asp Asp Ala 
    3980                 3985                 3990             


Glu Phe  Glu Leu Thr Glu Thr  Phe Asn Ile Ser Leu  Ile Ser Val 
    3995                 4000                 4005             


Ala Gly  Gly Gly Arg Leu Gly  Asp Asp Val Val Val  Thr Val Val 
    4010                 4015                 4020             


Ile Pro  Gln Asn Asp Ser Pro  Phe Gly Val Phe Gly  Phe Glu Glu 
    4025                 4030                 4035             


Lys Thr  Val Met Ile Asp Glu  Ser Leu Ser Ser Asp  Asp Pro Asp 
    4040                 4045                 4050             


Ser Tyr  Val Thr Leu Thr Val  Val Arg Ser Pro Gly  Gly Lys Gly 
    4055                 4060                 4065             


Thr Val  Arg Leu Glu Trp Thr  Ile Asp Glu Lys Ala  Lys His Asn 
    4070                 4075                 4080             


Leu Ser  Pro Leu Asn Gly Thr  Leu His Phe Asp Glu  Thr Glu Ser 
    4085                 4090                 4095             


Gln Lys  Thr Ile Val Leu His  Thr Leu Gln Asp Thr  Val Leu Glu 
    4100                 4105                 4110             


Glu Asp  Arg Arg Phe Thr Ile  Gln Leu Ile Ser Ile  Asp Glu Val 
    4115                 4120                 4125             


Glu Ile  Ser Pro Val Lys Gly  Ser Ala Ser Ile Ile  Ile Arg Gly 
    4130                 4135                 4140             


Asp Lys  Arg Ala Ser Gly Glu  Val Gly Ile Ala Pro  Ser Ser Arg 
    4145                 4150                 4155             


His Ile  Leu Ile Gly Glu Pro  Ser Ala Lys Tyr Asn  Gly Thr Ala 
    4160                 4165                 4170             


Ile Ile  Ser Leu Val Arg Gly  Pro Gly Ile Leu Gly  Glu Val Thr 
    4175                 4180                 4185             


Val Phe  Trp Arg Ile Phe Pro  Pro Ser Val Gly Glu  Phe Ala Glu 
    4190                 4195                 4200             


Thr Ser  Gly Lys Leu Thr Met  Arg Asp Glu Gln Ser  Ala Val Ile 
    4205                 4210                 4215             


Val Val  Ile Gln Ala Leu Asn  Asp Asp Ile Pro Glu  Glu Lys Ser 
    4220                 4225                 4230             


Phe Tyr  Glu Phe Gln Leu Thr  Ala Val Ser Glu Gly  Gly Val Leu 
    4235                 4240                 4245             


Ser Glu  Ser Ser Ser Thr Ala  Asn Ile Thr Val Val  Ala Ser Asp 
    4250                 4255                 4260             


Ser Pro  Tyr Gly Arg Phe Ala  Phe Ser His Glu Gln  Leu Arg Val 
    4265                 4270                 4275             


Ser Glu  Ala Gln Arg Val Asn  Ile Thr Ile Ile Arg  Ser Ser Gly 
    4280                 4285                 4290             


Asp Phe  Gly His Val Arg Leu  Trp Tyr Lys Thr Met  Ser Gly Thr 
    4295                 4300                 4305             


Ala Glu  Ala Gly Leu Asp Phe  Val Pro Ala Ala Gly  Glu Leu Leu 
    4310                 4315                 4320             


Phe Glu  Ala Gly Glu Met Arg  Lys Ser Leu His Val  Glu Ile Leu 
    4325                 4330                 4335             


Asp Asp  Asp Tyr Pro Glu Gly  Pro Glu Glu Phe Ser  Leu Thr Ile 
    4340                 4345                 4350             


Thr Lys  Val Glu Leu Gln Gly  Arg Gly Tyr Asp Phe  Thr Ile Gln 
    4355                 4360                 4365             


Glu Asn  Gly Leu Gln Ile Asp  Gln Pro Pro Glu Ile  Gly Asn Ile 
    4370                 4375                 4380             


Ser Ile  Val Arg Ile Ile Ile  Met Lys Asn Asp Asn  Ala Glu Gly 
    4385                 4390                 4395             


Ile Ile  Glu Phe Asp Pro Lys  Tyr Thr Ala Phe Glu  Val Glu Glu 
    4400                 4405                 4410             


Asp Val  Gly Leu Ile Met Ile  Pro Val Val Arg Leu  His Gly Thr 
    4415                 4420                 4425             


Tyr Gly  Tyr Val Thr Ala Asp  Phe Ile Ser Gln Ser  Ser Ser Ala 
    4430                 4435                 4440             


Ser Pro  Gly Gly Val Asp Tyr  Ile Leu His Gly Ser  Thr Val Thr 
    4445                 4450                 4455             


Phe Gln  His Gly Gln Asn Leu  Ser Phe Ile Asn Ile  Ser Ile Ile 
    4460                 4465                 4470             


Asp Asp  Asn Glu Ser Glu Phe  Glu Glu Pro Ile Glu  Ile Leu Leu 
    4475                 4480                 4485             


Thr Gly  Ala Thr Gly Gly Ala  Val Leu Gly Arg His  Leu Val Ser 
    4490                 4495                 4500             


Arg Ile  Ile Ile Ala Lys Ser  Asp Ser Pro Phe Gly  Val Ile Arg 
    4505                 4510                 4515             


Phe Leu  Asn Gln Ser Lys Ile  Ser Ile Ala Asn Pro  Asn Ser Thr 
    4520                 4525                 4530             


Met Ile  Leu Ser Leu Val Leu  Glu Arg Thr Gly Gly  Leu Leu Gly 
    4535                 4540                 4545             


Glu Ile  Gln Val Asn Trp Glu  Thr Val Gly Pro Asn  Ser Gln Glu 
    4550                 4555                 4560             


Ala Leu  Leu Pro Gln Asn Arg  Asp Ile Ala Asp Pro  Val Ser Gly 
    4565                 4570                 4575             


Leu Phe  Tyr Phe Gly Glu Gly  Glu Gly Gly Val Arg  Thr Ile Ile 
    4580                 4585                 4590             


Leu Thr  Ile Tyr Pro His Glu  Glu Ile Glu Val Glu  Glu Thr Phe 
    4595                 4600                 4605             


Ile Ile  Lys Leu His Leu Val  Lys Gly Glu Ala Lys  Leu Asp Ser 
    4610                 4615                 4620             


Arg Ala  Lys Asp Val Thr Leu  Thr Ile Gln Glu Phe  Gly Asp Pro 
    4625                 4630                 4635             


Asn Gly  Val Val Gln Phe Ala  Pro Glu Thr Leu Ser  Lys Lys Thr 
    4640                 4645                 4650             


Tyr Ser  Glu Pro Leu Ala Leu  Glu Gly Pro Leu Leu  Ile Thr Phe 
    4655                 4660                 4665             


Phe Val  Arg Arg Val Lys Gly  Thr Phe Gly Glu Ile  Met Val Tyr 
    4670                 4675                 4680             


Trp Glu  Leu Ser Ser Glu Phe  Asp Ile Thr Glu Asp  Phe Leu Ser 
    4685                 4690                 4695             


Thr Ser  Gly Phe Phe Thr Ile  Ala Asp Gly Glu Ser  Glu Ala Ser 
    4700                 4705                 4710             


Phe Asp  Val His Leu Leu Pro  Asp Glu Val Pro Glu  Ile Glu Glu 
    4715                 4720                 4725             


Asp Tyr  Val Ile Gln Leu Val  Ser Val Glu Gly Gly  Ala Glu Leu 
    4730                 4735                 4740             


Asp Leu  Glu Lys Ser Ile Thr  Trp Phe Ser Val Tyr  Ala Asn Asp 
    4745                 4750                 4755             


Asp Pro  His Gly Val Phe Ala  Leu Tyr Ser Asp Arg  Gln Ser Ile 
    4760                 4765                 4770             


Leu Ile  Gly Gln Asn Leu Ile  Arg Ser Ile Gln Ile  Asn Ile Thr 
    4775                 4780                 4785             


Arg Leu  Ala Gly Thr Phe Gly  Asp Val Ala Val Gly  Leu Arg Ile 
    4790                 4795                 4800             


Ser Ser  Asp His Lys Glu Gln  Pro Ile Val Thr Glu  Asn Ala Glu 
    4805                 4810                 4815             


Arg Gln  Leu Val Val Lys Asp  Gly Ala Thr Tyr Lys  Val Asp Val 
    4820                 4825                 4830             


Val Pro  Ile Lys Asn Gln Val  Phe Leu Ser Leu Gly  Ser Asn Phe 
    4835                 4840                 4845             


Thr Leu  Gln Leu Val Thr Val  Met Leu Val Gly Gly  Arg Phe Tyr 
    4850                 4855                 4860             


Gly Met  Pro Thr Ile Leu Gln  Glu Ala Lys Ser Ala  Val Leu Pro 
    4865                 4870                 4875             


Val Ser  Glu Lys Ala Ala Asn  Ser Gln Val Gly Phe  Glu Ser Thr 
    4880                 4885                 4890             


Ala Phe  Gln Leu Met Asn Ile  Thr Ala Gly Thr Ser  His Val Met 
    4895                 4900                 4905             


Ile Ser  Arg Arg Gly Thr Tyr  Gly Ala Leu Ser Val  Ala Trp Thr 
    4910                 4915                 4920             


Thr Gly  Tyr Ala Pro Gly Leu  Glu Ile Pro Glu Phe  Ile Val Val 
    4925                 4930                 4935             


Gly Asn  Met Thr Pro Thr Leu  Gly Ser Leu Ser Phe  Ser His Gly 
    4940                 4945                 4950             


Glu Gln  Arg Lys Gly Val Phe  Leu Trp Thr Phe Pro  Ser Pro Gly 
    4955                 4960                 4965             


Trp Pro  Glu Ala Phe Val Leu  His Leu Ser Gly Val  Gln Ser Ser 
    4970                 4975                 4980             


Ala Pro  Gly Gly Ala Gln Leu  Arg Ser Gly Phe Ile  Val Ala Glu 
    4985                 4990                 4995             


Ile Glu  Pro Met Gly Val Phe  Gln Phe Ser Thr Ser  Ser Arg Asn 
    5000                 5005                 5010             


Ile Ile  Val Ser Glu Asp Thr  Gln Met Ile Arg Leu  His Val Gln 
    5015                 5020                 5025             


Arg Leu  Phe Gly Phe His Ser  Asp Leu Ile Lys Val  Ser Tyr Gln 
    5030                 5035                 5040             


Thr Thr  Ala Gly Ser Ala Lys  Pro Leu Glu Asp Phe  Glu Pro Val 
    5045                 5050                 5055             


Gln Asn  Gly Glu Leu Phe Phe  Gln Lys Phe Gln Thr  Glu Val Asp 
    5060                 5065                 5070             


Phe Glu  Ile Thr Ile Ile Asn  Asp Gln Leu Ser Glu  Ile Glu Glu 
    5075                 5080                 5085             


Phe Phe  Tyr Ile Asn Leu Thr  Ser Val Glu Ile Arg  Gly Leu Gln 
    5090                 5095                 5100             


Lys Phe  Asp Val Asn Trp Ser  Pro Arg Leu Asn Leu  Asp Phe Ser 
    5105                 5110                 5115             


Val Ala  Val Ile Thr Ile Leu  Asp Asn Asp Asp Leu  Ala Gly Met 
    5120                 5125                 5130             


Asp Ile  Ser Phe Pro Glu Thr  Thr Val Ala Val Ala  Val Asp Thr 
    5135                 5140                 5145             


Thr Leu  Ile Pro Val Glu Thr  Glu Ser Thr Thr Tyr  Leu Ser Thr 
    5150                 5155                 5160             


Ser Lys  Thr Thr Thr Ile Leu  Gln Pro Thr Asn Val  Val Ala Ile 
    5165                 5170                 5175             


Val Thr  Glu Ala Thr Gly Val  Ser Ala Ile Pro Glu  Lys Leu Val 
    5180                 5185                 5190             


Thr Leu  His Gly Thr Pro Ala  Val Ser Glu Lys Pro  Asp Val Ala 
    5195                 5200                 5205             


Thr Val  Thr Ala Asn Val Ser  Ile His Gly Thr Phe  Ser Leu Gly 
    5210                 5215                 5220             


Pro Ser  Ile Val Tyr Ile Glu  Glu Glu Met Lys Asn  Gly Thr Phe 
    5225                 5230                 5235             


Asn Thr  Ala Glu Val Leu Ile  Arg Arg Thr Gly Gly  Phe Thr Gly 
    5240                 5245                 5250             


Asn Val  Ser Ile Thr Val Lys  Thr Phe Gly Glu Arg  Cys Ala Gln 
    5255                 5260                 5265             


Met Glu  Pro Asn Ala Leu Pro  Phe Arg Gly Ile Tyr  Gly Ile Ser 
    5270                 5275                 5280             


Asn Leu  Thr Trp Ala Val Glu  Glu Glu Asp Phe Glu  Glu Gln Thr 
    5285                 5290                 5295             


Leu Thr  Leu Ile Phe Leu Asp  Gly Glu Arg Glu Arg  Lys Val Ser 
    5300                 5305                 5310             


Val Gln  Ile Leu Asp Asp Asp  Glu Pro Glu Gly Gln  Glu Phe Phe 
    5315                 5320                 5325             


Tyr Val  Phe Leu Thr Asn Pro  Gln Gly Gly Ala Gln  Ile Val Glu 
    5330                 5335                 5340             


Glu Lys  Asp Asp Thr Gly Phe  Ala Ala Phe Ala Met  Val Ile Ile 
    5345                 5350                 5355             


Thr Gly  Ser Asp Leu His Asn  Gly Ile Ile Gly Phe  Ser Glu Glu 
    5360                 5365                 5370             


Ser Gln  Ser Gly Leu Glu Leu  Arg Glu Gly Ala Val  Met Arg Arg 
    5375                 5380                 5385             


Leu His  Leu Ile Val Thr Arg  Gln Pro Asn Arg Ala  Phe Glu Asp 
    5390                 5395                 5400             


Val Lys  Val Phe Trp Arg Val  Thr Leu Asn Lys Thr  Val Val Val 
    5405                 5410                 5415             


Leu Gln  Lys Asp Gly Val Asn  Leu Val Glu Glu Leu  Gln Ser Val 
    5420                 5425                 5430             


Ser Gly  Thr Thr Thr Cys Thr  Met Gly Gln Thr Lys  Cys Phe Ile 
    5435                 5440                 5445             


Ser Ile  Glu Leu Lys Pro Glu  Lys Val Pro Gln Val  Glu Val Tyr 
    5450                 5455                 5460             


Phe Phe  Val Glu Leu Tyr Glu  Ala Thr Ala Gly Ala  Ala Ile Asn 
    5465                 5470                 5475             


Asn Ser  Ala Arg Phe Ala Gln  Ile Lys Ile Leu Glu  Ser Asp Glu 
    5480                 5485                 5490             


Ser Gln  Ser Leu Val Tyr Phe  Ser Val Gly Ser Arg  Leu Ala Val 
    5495                 5500                 5505             


Ala His  Lys Lys Ala Thr Leu  Ile Ser Leu Gln Val  Ala Arg Asp 
    5510                 5515                 5520             


Ser Gly  Thr Gly Leu Met Met  Ser Val Asn Phe Ser  Thr Gln Glu 
    5525                 5530                 5535             


Leu Arg  Ser Ala Glu Thr Ile  Gly Arg Thr Ile Ile  Ser Pro Ala 
    5540                 5545                 5550             


Ile Ser  Gly Lys Asp Phe Val  Ile Thr Glu Gly Thr  Leu Val Phe 
    5555                 5560                 5565             


Glu Pro  Gly Gln Arg Ser Thr  Val Leu Asp Val Ile  Leu Thr Pro 
    5570                 5575                 5580             


Glu Thr  Gly Ser Leu Asn Ser  Phe Pro Lys Arg Phe  Gln Ile Val 
    5585                 5590                 5595             


Leu Phe  Asp Pro Lys Gly Gly  Ala Arg Ile Asp Lys  Val Tyr Gly 
    5600                 5605                 5610             


Thr Ala  Asn Ile Thr Leu Val  Ser Asp Ala Asp Ser  Gln Ala Ile 
    5615                 5620                 5625             


Trp Gly  Leu Ala Asp Gln Leu  His Gln Pro Val Asn  Asp Asp Ile 
    5630                 5635                 5640             


Leu Asn  Arg Val Leu His Thr  Ile Ser Met Lys Val  Ala Thr Glu 
    5645                 5650                 5655             


Asn Thr  Asp Glu Gln Leu Ser  Ala Met Met His Leu  Ile Glu Lys 
    5660                 5665                 5670             


Ile Thr  Thr Glu Gly Lys Ile  Gln Ala Phe Ser Val  Ala Ser Arg 
    5675                 5680                 5685             


Thr Leu  Phe Tyr Glu Ile Leu  Cys Ser Leu Ile Asn  Pro Lys Arg 
    5690                 5695                 5700             


Lys Asp  Thr Arg Gly Phe Ser  His Phe Ala Glu Val  Thr Glu Asn 
    5705                 5710                 5715             


Phe Ala  Phe Ser Leu Leu Thr  Asn Val Thr Cys Gly  Ser Pro Gly 
    5720                 5725                 5730             


Glu Lys  Ser Lys Thr Ile Leu  Asp Ser Cys Pro Tyr  Leu Ser Ile 
    5735                 5740                 5745             


Leu Ala  Leu His Trp Tyr Pro  Gln Gln Ile Asn Gly  His Lys Phe 
    5750                 5755                 5760             


Glu Gly  Lys Glu Gly Asp Tyr  Ile Arg Ile Pro Glu  Arg Leu Leu 
    5765                 5770                 5775             


Asp Val  Gln Asp Ala Glu Ile  Met Ala Gly Lys Ser  Thr Cys Lys 
    5780                 5785                 5790             


Leu Val  Gln Phe Thr Glu Tyr  Ser Ser Gln Gln Trp  Phe Ile Ser 
    5795                 5800                 5805             


Gly Asn  Asn Leu Pro Thr Leu  Lys Asn Lys Val Leu  Ser Leu Ser 
    5810                 5815                 5820             


Val Lys  Gly Gln Ser Ser Gln  Leu Leu Thr Asn Asp  Asn Glu Val 
    5825                 5830                 5835             


Leu Tyr  Arg Ile Tyr Ala Ala  Glu Pro Arg Ile Ile  Pro Gln Thr 
    5840                 5845                 5850             


Ser Leu  Cys Leu Leu Trp Asn  Gln Ala Ala Ala Ser  Trp Leu Ser 
    5855                 5860                 5865             


Asp Ser  Gln Phe Cys Lys Val  Val Glu Glu Thr Ala  Asp Tyr Val 
    5870                 5875                 5880             


Glu Cys  Ala Cys Ser His Met  Ser Val Tyr Ala Val  Tyr Ala Arg 
    5885                 5890                 5895             


Thr Asp  Asn Leu Ser Ser Tyr  Asn Glu Ala Phe Phe  Thr Ser Gly 
    5900                 5905                 5910             


Phe Ile  Cys Ile Ser Gly Leu  Cys Leu Ala Val Leu  Ser His Ile 
    5915                 5920                 5925             


Phe Cys  Ala Arg Tyr Ser Met  Phe Ala Ala Lys Leu  Leu Thr His 
    5930                 5935                 5940             


Met Met  Ala Ala Ser Leu Gly  Thr Gln Ile Leu Phe  Leu Ala Ser 
    5945                 5950                 5955             


Ala Tyr  Ala Ser Pro Gln Leu  Ala Glu Glu Ser Cys  Ser Ala Met 
    5960                 5965                 5970             


Ala Ala  Val Thr His Tyr Leu  Tyr Leu Cys Gln Phe  Ser Trp Met 
    5975                 5980                 5985             


Leu Ile  Gln Ser Val Asn Phe  Trp Tyr Val Leu Val  Met Asn Asp 
    5990                 5995                 6000             


Glu His  Thr Glu Arg Arg Tyr  Leu Leu Phe Phe Leu  Leu Ser Trp 
    6005                 6010                 6015             


Gly Leu  Pro Ala Phe Val Val  Ile Leu Leu Ile Val  Ile Leu Lys 
    6020                 6025                 6030             


Gly Ile  Tyr His Gln Ser Met  Ser Gln Ile Tyr Gly  Leu Ile His 
    6035                 6040                 6045             


Gly Asp  Leu Cys Phe Ile Pro  Asn Val Tyr Ala Ala  Leu Phe Thr 
    6050                 6055                 6060             


Ala Ala  Leu Val Pro Leu Thr  Cys Leu Val Val Val  Phe Val Val 
    6065                 6070                 6075             


Phe Ile  His Ala Tyr Gln Val  Lys Pro Gln Trp Lys  Ala Tyr Asp 
    6080                 6085                 6090             


Asp Val  Phe Arg Gly Arg Thr  Asn Ala Ala Glu Ile  Pro Leu Ile 
    6095                 6100                 6105             


Leu Tyr  Leu Phe Ala Leu Ile  Ser Val Thr Trp Leu  Trp Gly Gly 
    6110                 6115                 6120             


Leu His  Met Ala Tyr Arg His  Phe Trp Met Leu Val  Leu Phe Val 
    6125                 6130                 6135             


Ile Phe  Asn Ser Leu Gln Gly  Leu Tyr Val Phe Met  Val Tyr Phe 
    6140                 6145                 6150             


Ile Leu  His Asn Gln Met Cys  Cys Pro Met Lys Ala  Ser Tyr Thr 
    6155                 6160                 6165             


Val Glu  Met Asn Gly His Pro  Gly Pro Ser Thr Ala  Phe Phe Thr 
    6170                 6175                 6180             


Pro Gly  Ser Gly Met Pro Pro  Ala Gly Gly Glu Ile  Ser Lys Ser 
    6185                 6190                 6195             


Thr Gln  Asn Leu Ile Gly Ala  Met Glu Glu Val Pro  Pro Asp Trp 
    6200                 6205                 6210             


Glu Arg  Ala Ser Phe Gln Gln  Gly Ser Gln Ala Ser  Pro Asp Leu 
    6215                 6220                 6225             


Lys Pro  Ser Pro Gln Asn Gly  Ala Thr Phe Pro Ser  Ser Gly Gly 
    6230                 6235                 6240             


Tyr Gly  Gln Gly Ser Leu Ile  Ala Asp Glu Glu Ser  Gln Glu Phe 
    6245                 6250                 6255             


Asp Asp  Leu Ile Phe Ala Leu  Lys Thr Gly Ala Gly  Leu Ser Val 
    6260                 6265                 6270             


Ser Asp  Asn Glu Ser Gly Gln  Gly Ser Gln Glu Gly  Gly Thr Leu 
    6275                 6280                 6285             


Thr Asp  Ser Gln Ile Val Glu  Leu Arg Arg Ile Pro  Ile Ala Asp 
    6290                 6295                 6300             


Thr His  Leu 
    6305     


<210>  5300
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  5300

Met Ala Glu Ala Glu Gly Ser Ser Leu Leu Leu Leu Pro Pro Pro Pro 
1               5                   10                  15      


Pro Pro Pro Arg Met Ala Glu Val Glu Ala Pro Thr Ala Ala Glu Thr 
            20                  25                  30          


Asp Met Lys Gln Tyr Gln Gly Ser Gly Gly Val Ala Met Asp Val Glu 
        35                  40                  45              


Arg Ser Arg Phe Pro Tyr Cys Val Val Trp Thr Pro Ile Pro Val Leu 
    50                  55                  60                  


Thr Trp Phe Phe Pro Ile Ile Gly His Met Gly Ile Cys Thr Ser Thr 
65                  70                  75                  80  


Gly Val Ile Arg Asp Phe Ala Gly Pro Tyr Phe Val Ser Glu Asp Asn 
                85                  90                  95      


Met Ala Phe Gly Lys Pro Ala Lys Tyr Trp Lys Leu Asp Pro Ala Gln 
            100                 105                 110         


Val Tyr Ala Ser Gly Pro Asn Ala Trp Asp Thr Ala Val His Asp Ala 
        115                 120                 125             


Ser Glu Glu Tyr Lys His Arg Met His Asn Leu Cys Cys Asp Asn Cys 
    130                 135                 140                 


His Ser His Val Ala Leu Ala Leu Asn Leu Met Arg Tyr Asn Asn Ser 
145                 150                 155                 160 


Thr Asn Trp Asn Met Val Thr Leu Cys Phe Phe Cys Leu Leu Tyr Gly 
                165                 170                 175     


Lys Tyr Val Ser Val Gly Ala Phe Val Lys Thr Trp Leu Pro Phe Ile 
            180                 185                 190         


Leu Leu Leu Gly Ile Ile Leu Thr Val Ser Leu Val Phe Asn Leu Arg 
        195                 200                 205             


<210>  5301
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  5301

Met Arg Leu Leu Glu Arg Met Arg Lys Asp Trp Phe Met Val Gly Ile 
1               5                   10                  15      


Val Leu Ala Ile Ala Gly Ala Lys Leu Glu Pro Ser Ile Gly Val Asn 
            20                  25                  30          


Gly Gly Pro Leu Lys Pro Glu Ile Thr Val Ser Tyr Ile Ala Val Ala 
        35                  40                  45              


Thr Ile Phe Phe Asn Ser Gly Leu Ser Leu Lys Thr Glu Glu Leu Thr 
    50                  55                  60                  


Ser Ala Leu Val His Leu Lys Leu His Leu Phe Ile Gln Ile Phe Thr 
65                  70                  75                  80  


Leu Ala Phe Phe Pro Ala Thr Ile Trp Leu Phe Leu Gln Leu Leu Ser 
                85                  90                  95      


Ile Thr Pro Ile Asn Glu Trp Leu Leu Lys Gly Leu Gln Thr Val Gly 
            100                 105                 110         


Cys Met Pro Pro Pro Val Ser Ser Ala Val Ile Leu Thr Lys Ala Val 
        115                 120                 125             


Gly Gly Asn Glu Ala Ala Ala Ile Phe Asn Ser Ala Phe Gly Ser Phe 
    130                 135                 140                 


Leu Val Ser Lys His Ser Leu Thr Cys Leu Leu Gln Leu Leu Leu 
145                 150                 155                 


<210>  5302
<211>  573
<212>  PRT
<213>  Homo sapiens

<400>  5302

Met Thr Asn Ser Lys Gly Arg Ser Ile Thr Asp Lys Thr Ser Gly Gly 
1               5                   10                  15      


Pro Ser Ser Gly Gly Gly Phe Val Asp Trp Thr Leu Arg Leu Asn Thr 
            20                  25                  30          


Ile Gln Ser Asp Lys Phe Leu Asn Leu Leu Leu Ser Met Val Pro Val 
        35                  40                  45              


Ile Tyr Gln Lys Asn Gln Glu Asp Arg His Lys Lys Ala Asn Gly Ile 
    50                  55                  60                  


Trp Gln Asp Gly Leu Ser Thr Ala Val Gln Thr Phe Ser Asn Arg Ser 
65                  70                  75                  80  


Glu Gln His Met Glu Tyr His Ser Phe Ser Glu Gln Ser Phe His Ala 
                85                  90                  95      


Asn Asn Gly His Ala Ser Ser Ser Cys Ser Gln Lys Tyr Asp Asp Tyr 
            100                 105                 110         


Ala Asn Tyr Asn Tyr Cys Asp Gly Arg Glu Thr Ser Glu Thr Thr Ala 
        115                 120                 125             


Met Leu Gln Asp Glu Asp Ile Ser Ser Asp Gly Asp Glu Asp Ala Ile 
    130                 135                 140                 


Val Glu Val Thr Pro Lys Leu Pro Lys Glu Ser Ser Gly Ile Met Ala 
145                 150                 155                 160 


Leu Gln Ile Leu Val Pro Phe Leu Leu Ala Gly Phe Gly Thr Val Ser 
                165                 170                 175     


Ala Gly Met Val Leu Asp Ile Val Gln His Trp Glu Val Phe Arg Lys 
            180                 185                 190         


Val Thr Glu Val Phe Ile Leu Val Pro Ala Leu Leu Gly Leu Lys Gly 
        195                 200                 205             


Asn Leu Glu Met Thr Leu Ala Ser Arg Leu Ser Thr Ala Val Asn Ile 
    210                 215                 220                 


Gly Lys Met Asp Ser Pro Ile Glu Lys Trp Asn Leu Ile Ile Gly Asn 
225                 230                 235                 240 


Leu Ala Leu Lys Gln Val Gln Ala Thr Val Val Gly Phe Leu Ala Ala 
                245                 250                 255     


Val Ala Ala Ile Ile Leu Gly Trp Ile Pro Glu Gly Lys Tyr Tyr Leu 
            260                 265                 270         


Asp His Ser Ile Leu Leu Cys Ser Ser Ser Val Ala Thr Ala Phe Ile 
        275                 280                 285             


Ala Ser Leu Leu Gln Gly Ile Ile Met Val Gly Val Ile Val Gly Ser 
    290                 295                 300                 


Lys Lys Thr Gly Ile Asn Pro Asp Asn Val Ala Thr Pro Ile Ala Ala 
305                 310                 315                 320 


Ser Phe Gly Asp Leu Ile Thr Leu Ala Ile Leu Ala Trp Ile Ser Gln 
                325                 330                 335     


Gly Leu Tyr Ser Cys Leu Glu Thr Tyr Tyr Tyr Ile Ser Pro Leu Val 
            340                 345                 350         


Gly Val Phe Phe Leu Ala Leu Thr Pro Ile Trp Ile Ile Ile Ala Ala 
        355                 360                 365             


Lys His Pro Ala Thr Arg Thr Val Leu His Ser Gly Trp Glu Pro Val 
    370                 375                 380                 


Ile Thr Ala Met Val Ile Ser Ser Ile Gly Gly Leu Ile Leu Asp Thr 
385                 390                 395                 400 


Thr Val Ser Asp Pro Asn Leu Val Gly Ile Val Val Tyr Thr Pro Val 
                405                 410                 415     


Ile Asn Gly Ile Gly Gly Asn Leu Val Ala Ile Gln Ala Ser Arg Ile 
            420                 425                 430         


Ser Thr Tyr Leu His Leu His Ser Ile Pro Gly Glu Leu Pro Asp Glu 
        435                 440                 445             


Pro Lys Gly Cys Tyr Tyr Pro Phe Arg Thr Phe Phe Gly Pro Gly Val 
    450                 455                 460                 


Asn Asn Lys Ser Ala Gln Val Leu Leu Leu Leu Val Ile Pro Gly His 
465                 470                 475                 480 


Leu Ile Phe Leu Tyr Thr Ile His Leu Met Lys Ser Gly His Thr Ser 
                485                 490                 495     


Leu Thr Ile Ile Phe Ile Val Val Tyr Leu Phe Gly Ala Val Leu Gln 
            500                 505                 510         


Val Phe Thr Leu Leu Trp Ile Ala Asp Trp Met Val His His Phe Trp 
        515                 520                 525             


Arg Lys Gly Lys Asp Pro Asp Ser Phe Ser Ile Pro Tyr Leu Thr Ala 
    530                 535                 540                 


Leu Gly Asp Leu Leu Gly Thr Ala Leu Leu Ala Leu Ser Phe His Phe 
545                 550                 555                 560 


Leu Trp Leu Ile Gly Asp Arg Asp Gly Asp Val Gly Asp 
                565                 570             


<210>  5303
<211>  1222
<212>  PRT
<213>  Homo sapiens

<400>  5303

Met Pro Lys Gly Gly Ala Pro Pro Trp Ile Met Ala Leu Met Phe Thr 
1               5                   10                  15      


Gly His Leu Leu Phe Leu Ala Leu Leu Met Phe Ala Phe Ser Thr Phe 
            20                  25                  30          


Glu Glu Ser Val Ser Asn Tyr Ser Glu Trp Ala Val Phe Thr Asp Asp 
        35                  40                  45              


Ile Asp Gln Phe Lys Thr Gln Lys Val Gln Asp Phe Arg Pro Asn Gln 
    50                  55                  60                  


Lys Leu Lys Lys Ser Met Leu His Pro Ser Leu Tyr Phe Asp Ala Gly 
65                  70                  75                  80  


Glu Ile Gln Ala Met Arg Gln Lys Ser Arg Ala Ser His Leu His Leu 
                85                  90                  95      


Phe Arg Ala Ile Arg Ser Ala Val Thr Val Met Leu Ser Asn Pro Thr 
            100                 105                 110         


Tyr Tyr Leu Pro Pro Pro Lys His Ala Asp Phe Ala Ala Lys Trp Asn 
        115                 120                 125             


Glu Ile Tyr Gly Asn Asn Leu Pro Pro Leu Ala Leu Tyr Cys Leu Leu 
    130                 135                 140                 


Cys Pro Glu Asp Lys Val Ala Phe Glu Phe Val Leu Glu Tyr Met Asp 
145                 150                 155                 160 


Arg Met Val Gly Tyr Lys Asp Trp Leu Val Glu Asn Ala Pro Gly Asp 
                165                 170                 175     


Glu Val Pro Ile Gly His Ser Leu Thr Gly Phe Ala Thr Ala Phe Asp 
            180                 185                 190         


Phe Leu Tyr Asn Leu Leu Asp Asn His Arg Arg Gln Lys Tyr Leu Glu 
        195                 200                 205             


Lys Ile Trp Val Ile Thr Glu Glu Met Tyr Glu Tyr Ser Lys Val Arg 
    210                 215                 220                 


Ser Trp Gly Lys Gln Leu Leu His Asn His Gln Ala Thr Asn Met Ile 
225                 230                 235                 240 


Ala Leu Leu Thr Gly Ala Leu Val Thr Gly Val Asp Lys Gly Ser Lys 
                245                 250                 255     


Ala Asn Ile Trp Lys Gln Ala Val Val Asp Val Met Glu Lys Thr Met 
            260                 265                 270         


Phe Leu Leu Asn His Ile Val Asp Gly Ser Leu Asp Glu Gly Val Ala 
        275                 280                 285             


Tyr Gly Ser Tyr Thr Ala Lys Ser Val Thr Gln Tyr Val Phe Leu Ala 
    290                 295                 300                 


Gln Arg His Phe Asn Ile Asn Asn Leu Asp Asn Asn Trp Leu Lys Met 
305                 310                 315                 320 


His Phe Trp Phe Tyr Tyr Ala Thr Leu Leu Pro Gly Phe Gln Arg Thr 
                325                 330                 335     


Val Gly Ile Ala Asp Ser Asn Tyr Asn Trp Phe Tyr Gly Pro Glu Ser 
            340                 345                 350         


Gln Leu Val Phe Leu Asp Lys Phe Ile Leu Lys Asn Gly Ala Gly Asn 
        355                 360                 365             


Trp Leu Ala Gln Gln Ile Arg Lys His Arg Pro Lys Asp Gly Pro Met 
    370                 375                 380                 


Val Pro Ser Thr Ala Gln Arg Trp Ser Thr Leu His Thr Glu Tyr Ile 
385                 390                 395                 400 


Trp Tyr Asp Pro Gln Leu Thr Pro Gln Pro Pro Ala Asp Tyr Gly Thr 
                405                 410                 415     


Ala Lys Ile His Thr Phe Pro Asn Trp Gly Val Val Thr Tyr Gly Ala 
            420                 425                 430         


Gly Leu Pro Asn Thr Gln Thr Asn Thr Phe Val Ser Phe Lys Ser Gly 
        435                 440                 445             


Lys Leu Gly Gly Arg Ala Val Tyr Asp Ile Val His Phe Gln Pro Tyr 
    450                 455                 460                 


Ser Trp Ile Asp Gly Trp Arg Ser Phe Asn Pro Gly His Glu His Pro 
465                 470                 475                 480 


Asp Gln Asn Ser Phe Thr Phe Ala Pro Asn Gly Gln Val Phe Val Ser 
                485                 490                 495     


Glu Ala Leu Tyr Gly Pro Lys Leu Ser His Leu Asn Asn Val Leu Val 
            500                 505                 510         


Phe Ala Pro Ser Pro Ser Ser Gln Cys Asn Lys Pro Trp Glu Gly Gln 
        515                 520                 525             


Leu Gly Glu Cys Ala Gln Trp Leu Lys Trp Thr Gly Glu Glu Val Gly 
    530                 535                 540                 


Asp Ala Ala Gly Glu Ile Ile Thr Ala Ser Gln His Gly Glu Met Val 
545                 550                 555                 560 


Phe Val Ser Gly Glu Ala Val Ser Ala Tyr Ser Ser Ala Met Arg Leu 
                565                 570                 575     


Lys Ser Val Tyr Arg Ala Leu Leu Leu Leu Asn Ser Gln Thr Leu Leu 
            580                 585                 590         


Val Val Asp His Ile Glu Arg Gln Glu Asp Ser Pro Ile Asn Ser Val 
        595                 600                 605             


Ser Ala Phe Phe His Asn Leu Asp Ile Asp Phe Lys Tyr Ile Pro Tyr 
    610                 615                 620                 


Lys Phe Met Asn Arg Tyr Asn Gly Ala Met Met Asp Val Trp Asp Ala 
625                 630                 635                 640 


His Tyr Lys Met Phe Trp Phe Asp His His Gly Asn Ser Pro Met Ala 
                645                 650                 655     


Ser Ile Gln Glu Ala Glu Gln Ala Ala Glu Phe Lys Lys Arg Trp Thr 
            660                 665                 670         


Gln Phe Val Asn Val Thr Phe Gln Met Glu Pro Thr Ile Thr Arg Ile 
        675                 680                 685             


Ala Tyr Val Phe Tyr Gly Pro Tyr Ile Asn Val Ser Ser Cys Arg Phe 
    690                 695                 700                 


Ile Asp Ser Ser Asn Pro Gly Leu Gln Ile Ser Leu Asn Val Asn Asn 
705                 710                 715                 720 


Thr Glu His Val Val Ser Ile Val Thr Asp Tyr His Asn Leu Lys Thr 
                725                 730                 735     


Arg Phe Asn Tyr Leu Gly Phe Gly Gly Phe Ala Ser Val Ala Asp Gln 
            740                 745                 750         


Gly Gln Ile Thr Arg Phe Gly Leu Gly Thr Gln Ala Ile Val Lys Pro 
        755                 760                 765             


Val Arg His Asp Arg Ile Ile Phe Pro Phe Gly Phe Lys Phe Asn Ile 
    770                 775                 780                 


Ala Val Gly Leu Ile Leu Cys Ile Ser Leu Val Ile Leu Thr Phe Gln 
785                 790                 795                 800 


Trp Arg Phe Tyr Leu Ser Phe Arg Lys Leu Met Arg Trp Ile Leu Ile 
                805                 810                 815     


Leu Val Ile Ala Leu Trp Phe Ile Glu Leu Leu Asp Val Trp Ser Thr 
            820                 825                 830         


Cys Ser Gln Pro Ile Cys Ala Lys Trp Thr Arg Thr Glu Ala Glu Gly 
        835                 840                 845             


Ser Lys Lys Ser Leu Ser Ser Glu Gly His His Met Asp Leu Pro Asp 
    850                 855                 860                 


Val Val Ile Thr Ser Leu Pro Gly Ser Gly Ala Glu Ile Leu Lys Gln 
865                 870                 875                 880 


Leu Phe Phe Asn Ser Ser Asp Phe Leu Tyr Ile Arg Val Pro Thr Ala 
                885                 890                 895     


Tyr Ile Asp Ile Pro Glu Thr Glu Leu Glu Ile Asp Ser Phe Val Asp 
            900                 905                 910         


Ala Cys Glu Trp Lys Val Ser Asp Ile Arg Ser Gly His Phe Arg Leu 
        915                 920                 925             


Leu Arg Gly Trp Leu Gln Ser Leu Val Gln Asp Thr Lys Leu His Leu 
    930                 935                 940                 


Gln Asn Ile His Leu His Glu Pro Asn Arg Gly Lys Leu Ala Gln Tyr 
945                 950                 955                 960 


Phe Ala Met Asn Lys Asp Lys Lys Arg Lys Phe Lys Arg Arg Glu Ser 
                965                 970                 975     


Leu Pro Glu Gln Arg Ser Gln Met Lys Gly Ala Phe Asp Arg Asp Ala 
            980                 985                 990         


Glu Tyr Ile Arg Ala Leu Arg Arg  His Leu Val Tyr Tyr  Pro Ser Ala 
        995                 1000                 1005             


Arg Pro  Val Leu Ser Leu Ser  Ser Gly Ser Trp Thr  Leu Lys Leu 
    1010                 1015                 1020             


His Phe  Phe Gln Glu Val Leu  Gly Ala Ser Met Arg  Ala Leu Tyr 
    1025                 1030                 1035             


Ile Val  Arg Asp Pro Arg Ala  Trp Ile Tyr Ser Met  Leu Tyr Asn 
    1040                 1045                 1050             


Ser Lys  Pro Ser Leu Tyr Ser  Leu Lys Asn Val Pro  Glu His Leu 
    1055                 1060                 1065             


Ala Lys  Leu Phe Lys Ile Glu  Gly Gly Lys Gly Lys  Cys Asn Leu 
    1070                 1075                 1080             


Asn Ser  Gly Tyr Ala Phe Glu  Tyr Glu Pro Leu Arg  Lys Glu Leu 
    1085                 1090                 1095             


Ser Lys  Ser Lys Ser Asn Ala  Val Ser Leu Leu Ser  His Leu Trp 
    1100                 1105                 1110             


Leu Ala  Asn Thr Ala Ala Ala  Leu Arg Ile Asn Thr  Asp Leu Leu 
    1115                 1120                 1125             


Pro Thr  Ser Tyr Gln Leu Val  Lys Phe Glu Asp Ile  Val His Phe 
    1130                 1135                 1140             


Pro Gln  Lys Thr Thr Glu Arg  Ile Phe Ala Phe Leu  Gly Ile Pro 
    1145                 1150                 1155             


Leu Ser  Pro Ala Ser Leu Asn  Gln Ile Leu Phe Ala  Thr Ser Thr 
    1160                 1165                 1170             


Asn Leu  Phe Tyr Leu Pro Tyr  Glu Gly Glu Ile Ser  Pro Thr Asn 
    1175                 1180                 1185             


Thr Asn  Val Trp Lys Gln Asn  Leu Pro Arg Asp Glu  Ile Lys Leu 
    1190                 1195                 1200             


Ile Glu  Asn Ile Cys Trp Thr  Leu Met Asp Arg Leu  Gly Tyr Pro 
    1205                 1210                 1215             


Lys Phe  Met Asp 
    1220         


<210>  5304
<211>  836
<212>  PRT
<213>  Homo sapiens

<400>  5304

Met His Pro Leu Gly Leu Cys Asn Asn Asn Asp Glu Glu Asp Leu Tyr 
1               5                   10                  15      


Glu Tyr Gly Trp Val Gly Val Val Lys Leu Glu Gln Pro Glu Leu Asp 
            20                  25                  30          


Pro Lys Pro Cys Leu Thr Val Leu Gly Lys Ala Lys Arg Ala Val Gln 
        35                  40                  45              


Arg Gly Ala Thr Ala Val Ile Phe Asp Val Ser Glu Asn Pro Glu Ala 
    50                  55                  60                  


Ile Asp Gln Leu Asn Gln Gly Ser Glu Asp Pro Leu Lys Arg Pro Val 
65                  70                  75                  80  


Val Tyr Val Lys Gly Ala Asp Ala Ile Lys Leu Met Asn Ile Val Asn 
                85                  90                  95      


Lys Gln Lys Val Ala Arg Ala Arg Ile Gln His Arg Pro Pro Arg Gln 
            100                 105                 110         


Pro Thr Glu Tyr Phe Asp Met Gly Ile Phe Leu Ala Phe Phe Val Val 
        115                 120                 125             


Val Ser Leu Val Cys Leu Ile Leu Leu Val Lys Ile Lys Leu Lys Gln 
    130                 135                 140                 


Arg Arg Ser Gln Asn Ser Met Asn Arg Leu Ala Val Gln Ala Leu Glu 
145                 150                 155                 160 


Lys Met Glu Thr Arg Lys Phe Asn Ser Lys Ser Lys Gly Arg Arg Glu 
                165                 170                 175     


Gly Ser Cys Gly Ala Leu Asp Thr Leu Ser Ser Ser Ser Thr Ser Asp 
            180                 185                 190         


Cys Ala Ile Cys Leu Glu Lys Tyr Ile Asp Gly Glu Glu Leu Arg Val 
        195                 200                 205             


Ile Pro Cys Thr His Arg Phe His Arg Lys Cys Val Asp Pro Trp Leu 
    210                 215                 220                 


Leu Gln His His Thr Cys Pro His Cys Arg His Asn Ile Ile Glu Gln 
225                 230                 235                 240 


Lys Gly Asn Pro Ser Ala Val Cys Val Glu Thr Ser Asn Leu Ser Arg 
                245                 250                 255     


Gly Arg Gln Gln Arg Val Thr Leu Pro Val His Tyr Pro Gly Arg Val 
            260                 265                 270         


His Arg Thr Asn Ala Ile Pro Ala Tyr Pro Thr Arg Thr Ser Met Asp 
        275                 280                 285             


Ser His Gly Asn Pro Val Thr Leu Leu Thr Met Asp Arg His Gly Glu 
    290                 295                 300                 


Gln Ser Leu Tyr Ser Pro Gln Thr Pro Ala Tyr Ile Arg Ser Tyr Pro 
305                 310                 315                 320 


Pro Leu His Leu Asp His Ser Leu Ala Ala His Arg Cys Gly Leu Glu 
                325                 330                 335     


His Arg Ala Tyr Ser Pro Ala His Pro Phe Arg Arg Pro Lys Leu Ser 
            340                 345                 350         


Gly Arg Ser Phe Ser Lys Ala Ala Cys Phe Ser Gln Tyr Glu Thr Met 
        355                 360                 365             


Tyr Gln His Tyr Tyr Phe Gln Gly Leu Ser Tyr Pro Glu Gln Glu Gly 
    370                 375                 380                 


Gln Ser Pro Pro Ser Leu Ala Pro Arg Gly Pro Ala Arg Ala Phe Pro 
385                 390                 395                 400 


Pro Ser Gly Ser Gly Ser Leu Leu Phe Pro Thr Val Val His Val Ala 
                405                 410                 415     


Pro Pro Ser His Leu Glu Ser Gly Ser Thr Ser Ser Phe Ser Cys Tyr 
            420                 425                 430         


His Gly His Arg Ser Val Cys Ser Gly Tyr Leu Ala Asp Cys Pro Gly 
        435                 440                 445             


Ser Asp Ser Ser Ser Ser Ser Ser Ser Gly Gln Cys His Cys Ser Ser 
    450                 455                 460                 


Ser Asp Ser Val Val Asp Cys Thr Glu Val Ser Asn Gln Gly Val Tyr 
465                 470                 475                 480 


Gly Ser Cys Ser Thr Phe Arg Ser Ser Leu Ser Ser Asp Tyr Asp Pro 
                485                 490                 495     


Phe Ile Tyr Arg Ser Arg Ser Pro Cys Arg Ala Ser Glu Ala Gly Gly 
            500                 505                 510         


Ser Gly Ser Ser Gly Arg Gly Pro Ala Leu Cys Phe Glu Gly Ser Pro 
        515                 520                 525             


Pro Pro Glu Glu Leu Pro Ala Val His Ser His Gly Ala Gly Arg Gly 
    530                 535                 540                 


Glu Pro Trp Pro Gly Pro Ala Ser Pro Ser Gly Asp Gln Val Ser Thr 
545                 550                 555                 560 


Cys Ser Leu Glu Met Asn Tyr Ser Ser Asn Ser Ser Leu Glu His Arg 
                565                 570                 575     


Gly Pro Asn Ser Ser Thr Ser Glu Val Gly Leu Glu Ala Ser Pro Gly 
            580                 585                 590         


Ala Ala Pro Asp Leu Arg Arg Thr Trp Lys Gly Gly His Glu Leu Pro 
        595                 600                 605             


Ser Cys Ala Cys Cys Cys Glu Pro Gln Pro Ser Pro Ala Gly Pro Ser 
    610                 615                 620                 


Ala Gly Ala Ala Gly Ser Ser Thr Leu Phe Leu Gly Pro His Leu Tyr 
625                 630                 635                 640 


Glu Gly Ser Gly Pro Ala Gly Gly Glu Pro Gln Ser Gly Ser Ser Gln 
                645                 650                 655     


Gly Leu Tyr Gly Leu His Pro Asp His Leu Pro Arg Thr Asp Gly Val 
            660                 665                 670         


Lys Tyr Glu Gly Leu Pro Cys Cys Phe Tyr Glu Glu Lys Gln Val Ala 
        675                 680                 685             


Arg Gly Gly Gly Gly Gly Ser Gly Cys Tyr Thr Glu Asp Tyr Ser Val 
    690                 695                 700                 


Ser Val Gln Tyr Thr Leu Thr Glu Glu Pro Pro Pro Gly Cys Tyr Pro 
705                 710                 715                 720 


Gly Ala Arg Asp Leu Ser Gln Arg Ile Pro Ile Ile Pro Glu Asp Val 
                725                 730                 735     


Asp Cys Asp Leu Gly Leu Pro Ser Asp Cys Gln Gly Thr His Ser Leu 
            740                 745                 750         


Gly Ser Trp Gly Gly Thr Arg Gly Pro Asp Thr Pro Arg Pro His Arg 
        755                 760                 765             


Gly Leu Gly Ala Thr Arg Glu Glu Glu Arg Ala Leu Cys Cys Gln Ala 
    770                 775                 780                 


Arg Ala Leu Leu Arg Pro Gly Cys Pro Pro Glu Glu Ala Gly Ala Val 
785                 790                 795                 800 


Arg Ala Asn Phe Pro Ser Ala Leu Gln Asp Thr Gln Glu Ser Ser Thr 
                805                 810                 815     


Thr Ala Thr Glu Ala Ala Gly Pro Arg Ser His Ser Ala Asp Ser Ser 
            820                 825                 830         


Ser Pro Gly Ala 
        835     


<210>  5305
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  5305

Met Arg Leu Pro Leu Ser His Ser Pro Glu His Val Glu Met Ala Leu 
1               5                   10                  15      


Leu Ser Asn Ile Leu Ala Ala Tyr Ser Phe Val Ser Glu Asn Pro Glu 
            20                  25                  30          


Arg Ala Ala Leu Tyr Phe Val Ser Gly Val Cys Ile Gly Leu Val Leu 
        35                  40                  45              


Thr Leu Ala Ala Leu Val Ile Arg Ile Ser Cys His Thr Asp Cys Arg 
    50                  55                  60                  


Arg Arg Pro Gly Lys Lys Phe Leu Gln Asp Arg Glu Ser Ser Ser Asp 
65                  70                  75                  80  


Ser Ser Asp Ser Glu Asp Gly Ser Glu Asp Thr Val Ser Asp Leu Ser 
                85                  90                  95      


Val Arg Arg His Arg Arg Phe Glu Arg Thr Leu Asn Lys Asn Val Phe 
            100                 105                 110         


Thr Ser Ala Glu Glu Leu Glu Arg Ala Gln Arg Leu Glu Glu Arg Glu 
        115                 120                 125             


Arg Ile Ile Arg Glu Ile Trp Met Asn Gly Gln Pro Glu Val Pro Gly 
    130                 135                 140                 


Thr Arg Ser Leu Asn Arg Tyr Tyr 
145                 150         


<210>  5306
<211>  1191
<212>  PRT
<213>  Homo sapiens

<400>  5306

Met Asp Cys Ser Leu Val Arg Thr Leu Val His Arg Tyr Cys Ala Gly 
1               5                   10                  15      


Glu Glu Asn Trp Val Asp Ser Arg Thr Ile Tyr Val Gly His Arg Glu 
            20                  25                  30          


Pro Pro Pro Gly Ala Glu Ala Tyr Ile Pro Gln Arg Tyr Pro Asp Asn 
        35                  40                  45              


Arg Ile Val Ser Ser Lys Tyr Thr Phe Trp Asn Phe Ile Pro Lys Asn 
    50                  55                  60                  


Leu Phe Glu Gln Phe Arg Arg Val Ala Asn Phe Tyr Phe Leu Ile Ile 
65                  70                  75                  80  


Phe Leu Val Gln Leu Ile Ile Asp Thr Pro Thr Ser Pro Val Thr Ser 
                85                  90                  95      


Gly Leu Pro Leu Phe Phe Val Ile Thr Val Thr Ala Ile Lys Gln Gly 
            100                 105                 110         


Tyr Glu Asp Trp Leu Arg His Lys Ala Asp Asn Ala Met Asn Gln Cys 
        115                 120                 125             


Pro Val His Phe Ile Gln His Gly Lys Leu Val Arg Lys Gln Ser Arg 
    130                 135                 140                 


Lys Leu Arg Val Gly Asp Ile Val Met Val Lys Glu Asp Glu Thr Phe 
145                 150                 155                 160 


Pro Cys Asp Leu Ile Phe Leu Ser Ser Asn Arg Gly Asp Gly Thr Cys 
                165                 170                 175     


His Val Thr Thr Ala Ser Leu Asp Gly Glu Ser Ser His Lys Thr His 
            180                 185                 190         


Tyr Ala Val Gln Asp Thr Lys Gly Phe His Thr Glu Glu Asp Ile Gly 
        195                 200                 205             


Gly Leu His Ala Thr Ile Glu Cys Glu Gln Pro Gln Pro Asp Leu Tyr 
    210                 215                 220                 


Lys Phe Val Gly Arg Ile Asn Val Tyr Ser Asp Leu Asn Asp Pro Val 
225                 230                 235                 240 


Val Arg Pro Leu Gly Ser Glu Asn Leu Leu Leu Arg Gly Ala Thr Leu 
                245                 250                 255     


Lys Asn Thr Glu Lys Ile Phe Gly Val Ala Ile Tyr Thr Gly Met Glu 
            260                 265                 270         


Thr Lys Met Ala Leu Asn Tyr Gln Ser Lys Ser Gln Lys Arg Ser Ala 
        275                 280                 285             


Val Glu Lys Ser Met Asn Ala Phe Leu Ile Val Tyr Leu Cys Ile Leu 
    290                 295                 300                 


Ile Ser Lys Ala Leu Ile Asn Thr Val Leu Lys Tyr Met Trp Gln Ser 
305                 310                 315                 320 


Glu Pro Phe Arg Asp Glu Pro Trp Tyr Asn Gln Lys Thr Glu Ser Glu 
                325                 330                 335     


Arg Gln Arg Asn Leu Phe Leu Lys Ala Phe Thr Asp Phe Leu Ala Phe 
            340                 345                 350         


Met Val Leu Phe Asn Tyr Ile Ile Pro Val Ser Met Tyr Val Thr Val 
        355                 360                 365             


Glu Met Gln Lys Phe Leu Gly Ser Tyr Phe Ile Thr Trp Asp Glu Asp 
    370                 375                 380                 


Met Phe Asp Glu Glu Thr Gly Glu Gly Pro Leu Val Asn Thr Ser Asp 
385                 390                 395                 400 


Leu Asn Glu Glu Leu Gly Gln Val Glu Tyr Ile Phe Thr Asp Lys Thr 
                405                 410                 415     


Gly Thr Leu Thr Glu Asn Asn Met Glu Phe Lys Glu Cys Cys Ile Glu 
            420                 425                 430         


Gly His Val Tyr Val Pro His Val Ile Cys Asn Gly Gln Val Leu Pro 
        435                 440                 445             


Glu Ser Ser Gly Ile Asp Met Ile Asp Ser Ser Pro Ser Val Asn Gly 
    450                 455                 460                 


Arg Glu Arg Glu Glu Leu Phe Phe Arg Ala Leu Cys Leu Cys His Thr 
465                 470                 475                 480 


Val Gln Val Lys Asp Asp Asp Ser Val Asp Gly Pro Arg Lys Ser Pro 
                485                 490                 495     


Asp Gly Gly Lys Ser Cys Val Tyr Ile Ser Ser Ser Pro Asp Glu Val 
            500                 505                 510         


Ala Leu Val Glu Gly Val Gln Arg Leu Gly Phe Thr Tyr Leu Arg Leu 
        515                 520                 525             


Lys Asp Asn Tyr Met Glu Ile Leu Asn Arg Glu Asn His Ile Glu Arg 
    530                 535                 540                 


Phe Glu Leu Leu Glu Ile Leu Ser Phe Asp Ser Val Arg Arg Arg Met 
545                 550                 555                 560 


Ser Val Ile Val Lys Ser Ala Thr Gly Glu Ile Tyr Leu Phe Cys Lys 
                565                 570                 575     


Gly Ala Asp Ser Ser Ile Phe Pro Arg Val Ile Glu Gly Lys Val Asp 
            580                 585                 590         


Gln Ile Arg Ala Arg Val Glu Arg Asn Ala Val Glu Gly Leu Arg Thr 
        595                 600                 605             


Leu Cys Val Ala Tyr Lys Arg Leu Ile Gln Glu Glu Tyr Glu Gly Ile 
    610                 615                 620                 


Cys Lys Leu Leu Gln Ala Ala Lys Val Ala Leu Gln Asp Arg Glu Lys 
625                 630                 635                 640 


Lys Leu Ala Glu Ala Tyr Glu Gln Ile Glu Lys Asp Leu Thr Leu Leu 
                645                 650                 655     


Gly Ala Thr Ala Val Glu Asp Arg Leu Gln Glu Lys Ala Ala Asp Thr 
            660                 665                 670         


Ile Glu Ala Leu Gln Lys Ala Gly Ile Lys Val Trp Val Leu Thr Gly 
        675                 680                 685             


Asp Lys Met Glu Thr Ala Ala Ala Thr Cys Tyr Ala Cys Lys Leu Phe 
    690                 695                 700                 


Arg Arg Asn Thr Gln Leu Leu Glu Leu Thr Thr Lys Arg Ile Glu Glu 
705                 710                 715                 720 


Gln Ser Leu His Asp Val Leu Phe Glu Leu Ser Lys Thr Val Leu Arg 
                725                 730                 735     


His Ser Gly Ser Leu Thr Arg Asp Asn Leu Ser Gly Leu Ser Ala Asp 
            740                 745                 750         


Met Gln Asp Tyr Gly Leu Ile Ile Asp Gly Ala Ala Leu Ser Leu Ile 
        755                 760                 765             


Met Lys Pro Arg Glu Asp Gly Ser Ser Gly Asn Tyr Arg Glu Leu Phe 
    770                 775                 780                 


Leu Glu Ile Cys Arg Ser Cys Ser Ala Val Leu Cys Cys Arg Met Ala 
785                 790                 795                 800 


Pro Leu Gln Lys Ala Gln Ile Val Lys Leu Ile Lys Phe Ser Lys Glu 
                805                 810                 815     


His Pro Ile Thr Leu Ala Ile Gly Asp Gly Ala Asn Asp Val Ser Met 
            820                 825                 830         


Ile Leu Glu Ala His Val Gly Ile Gly Val Ile Gly Lys Glu Gly Arg 
        835                 840                 845             


Gln Ala Ala Arg Asn Ser Asp Tyr Ala Ile Pro Lys Phe Lys His Leu 
    850                 855                 860                 


Lys Lys Met Leu Leu Val His Gly His Phe Tyr Tyr Ile Arg Ile Ser 
865                 870                 875                 880 


Glu Leu Val Gln Tyr Phe Phe Tyr Lys Asn Val Cys Phe Ile Phe Pro 
                885                 890                 895     


Gln Phe Leu Tyr Gln Phe Phe Cys Gly Phe Ser Gln Gln Thr Leu Tyr 
            900                 905                 910         


Asp Thr Ala Tyr Leu Thr Leu Tyr Asn Ile Ser Phe Thr Ser Leu Pro 
        915                 920                 925             


Ile Leu Leu Tyr Ser Leu Met Glu Gln His Val Gly Ile Asp Val Leu 
    930                 935                 940                 


Lys Arg Asp Pro Thr Leu Tyr Arg Asp Val Ala Lys Asn Ala Leu Leu 
945                 950                 955                 960 


Arg Trp Arg Val Phe Ile Tyr Trp Thr Leu Leu Gly Leu Phe Asp Ala 
                965                 970                 975     


Leu Val Phe Phe Phe Gly Ala Tyr Phe Val Phe Glu Asn Thr Thr Val 
            980                 985                 990         


Thr Ser Asn Gly Gln Ile Phe Gly  Asn Trp Thr Phe Gly  Thr Leu Val 
        995                 1000                 1005             


Phe Thr  Val Met Val Phe Thr  Val Thr Leu Lys Leu  Ala Leu Asp 
    1010                 1015                 1020             


Thr His  Tyr Trp Thr Trp Ile  Asn His Phe Val Ile  Trp Gly Ser 
    1025                 1030                 1035             


Leu Leu  Phe Tyr Val Val Phe  Ser Leu Leu Trp Gly  Gly Val Ile 
    1040                 1045                 1050             


Trp Pro  Phe Leu Asn Tyr Gln  Arg Met Tyr Tyr Val  Phe Ile Gln 
    1055                 1060                 1065             


Met Leu  Ser Ser Gly Pro Ala  Trp Leu Ala Ile Val  Leu Leu Val 
    1070                 1075                 1080             


Thr Ile  Ser Leu Leu Pro Asp  Val Leu Lys Lys Val  Leu Cys Arg 
    1085                 1090                 1095             


Gln Leu  Trp Pro Thr Ala Thr  Glu Arg Val Gln Asn  Gly Cys Ala 
    1100                 1105                 1110             


Gln Pro  Arg Asp Arg Asp Ser  Glu Phe Thr Pro Leu  Ala Ser Leu 
    1115                 1120                 1125             


Gln Ser  Pro Gly Tyr Gln Ser  Thr Cys Pro Ser Ala  Ala Trp Tyr 
    1130                 1135                 1140             


Ser Ser  His Ser Gln Gln Val  Thr Leu Ala Ala Trp  Lys Glu Lys 
    1145                 1150                 1155             


Val Ser  Thr Glu Pro Pro Pro  Ile Leu Gly Gly Ser  His His His 
    1160                 1165                 1170             


Cys Ser  Ser Ile Pro Ser His  Ser Cys Pro Arg Ser  Arg Val Gly 
    1175                 1180                 1185             


Met Leu  Val 
    1190     


<210>  5307
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  5307

Met Ala Thr Ala Glu Arg Arg Ala Leu Gly Ile Gly Phe Gln Trp Leu 
1               5                   10                  15      


Ser Leu Ala Thr Leu Val Leu Ile Cys Ala Gly Gln Gly Gly Arg Arg 
            20                  25                  30          


Glu Asp Gly Gly Pro Ala Cys Tyr Gly Gly Phe Asp Leu Tyr Phe Ile 
        35                  40                  45              


Leu Asp Lys Ser Gly Ser Val Leu His His Trp Asn Glu Ile Tyr Tyr 
    50                  55                  60                  


Phe Val Glu Gln Leu Ala His Lys Phe Ile Ser Pro Gln Leu Arg Met 
65                  70                  75                  80  


Ser Phe Ile Val Phe Ser Thr Arg Gly Thr Thr Leu Met Lys Leu Thr 
                85                  90                  95      


Glu Asp Arg Glu Gln Ile Arg Gln Gly Leu Glu Glu Leu Gln Lys Val 
            100                 105                 110         


Leu Pro Gly Gly Asp Thr Tyr Met His Glu Gly Phe Glu Arg Ala Ser 
        115                 120                 125             


Glu Gln Ile Tyr Tyr Glu Asn Arg Gln Gly Tyr Arg Thr Ala Ser Val 
    130                 135                 140                 


Ile Ile Ala Leu Thr Asp Gly Glu Leu His Glu Asp Leu Phe Phe Tyr 
145                 150                 155                 160 


Ser Glu Arg Glu Ala Asn Arg Ser Arg Asp Leu Gly Ala Ile Val Tyr 
                165                 170                 175     


Cys Val Gly Val Lys Asp Phe Asn Glu Thr Gln Leu Ala Arg Ile Ala 
            180                 185                 190         


Asp Ser Lys Asp His Val Phe Pro Val Asn Asp Gly Phe Gln Ala Leu 
        195                 200                 205             


Gln Gly Ile Ile His Ser Ile Leu Lys Lys Ser Cys Ile Glu Ile Leu 
    210                 215                 220                 


Ala Ala Glu Pro Ser Thr Ile Cys Ala Gly Glu Ser Phe Gln Val Val 
225                 230                 235                 240 


Val Arg Gly Asn Gly Phe Arg His Ala Arg Asn Val Asp Arg Val Leu 
                245                 250                 255     


Cys Ser Phe Lys Ile Asn Asp Ser Val Thr Leu Asn Glu Lys Pro Phe 
            260                 265                 270         


Ser Val Glu Asp Thr Tyr Leu Leu Cys Pro Ala Pro Ile Leu Lys Glu 
        275                 280                 285             


Val Gly Met Lys Ala Ala Leu Gln Val Ser Met Asn Asp Gly Leu Ser 
    290                 295                 300                 


Phe Ile Ser Ser Ser Val Ile Ile Thr Thr Thr His Cys Ser Asp Gly 
305                 310                 315                 320 


Ser Ile Leu Ala Ile Ala Leu Leu Ile Leu Phe Leu Leu Leu Ala Leu 
                325                 330                 335     


Ala Leu Leu Trp Trp Phe Trp Pro Leu Cys Cys Thr Val Ile Ile Lys 
            340                 345                 350         


Glu Val Pro Pro Pro Pro Ala Glu Glu Ser Glu Glu Glu Asp Asp Asp 
        355                 360                 365             


Gly Leu Pro Lys Lys Lys Trp Pro Thr Val Asp Ala Ser Tyr Tyr Gly 
    370                 375                 380                 


Gly Arg Gly Val Gly Gly Ile Lys Arg Met Glu Val Arg Trp Gly Glu 
385                 390                 395                 400 


Lys Gly Ser Thr Glu Glu Gly Ala Lys Leu Glu Lys Ala Lys Asn Ala 
                405                 410                 415     


Arg Val Lys Met Pro Glu Gln Glu Tyr Glu Phe Pro Glu Pro Arg Asn 
            420                 425                 430         


Leu Asn Asn Asn Met Arg Arg Pro Ser Ser Pro Arg Lys Trp Tyr Ser 
        435                 440                 445             


Pro Ile Lys Gly Lys Leu Asp Ala Leu Trp Val Leu Leu Arg Lys Gly 
    450                 455                 460                 


Tyr Asp Arg Val Ser Val Met Arg Pro Gln Pro Gly Asp Thr Gly Arg 
465                 470                 475                 480 


Cys Ile Asn Phe Thr Arg Val Lys Asn Asn Gln Pro Ala Lys Tyr Pro 
                485                 490                 495     


Leu Asn Asn Ala Tyr His Thr Ser Ser Pro Pro Pro Ala Pro Ile Tyr 
            500                 505                 510         


Thr Pro Pro Pro Pro Ala Pro His Cys Pro Pro Pro Pro Pro Ser Ala 
        515                 520                 525             


Pro Thr Pro Pro Ile Pro Ser Pro Pro Ser Thr Leu Pro Pro Pro Pro 
    530                 535                 540                 


Gln Ala Pro Pro Pro Asn Arg Ala Pro Pro Pro Ser Arg Pro Pro Pro 
545                 550                 555                 560 


Arg Pro Ser Val 
                


<210>  5308
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  5308

Met Ala Gly Pro Thr Glu Ala Glu Thr Gly Leu Ala Glu Pro Arg Ala 
1               5                   10                  15      


Leu Cys Ala Gln Arg Gly His Arg Thr Tyr Ala Arg Arg Trp Val Phe 
            20                  25                  30          


Leu Leu Ala Ile Ser Leu Leu Asn Cys Ser Asn Ala Thr Leu Trp Leu 
        35                  40                  45              


Ser Phe Ala Pro Val Ala Asp Val Ile Ala Glu Asp Leu Val Leu Ser 
    50                  55                  60                  


Met Glu Gln Ile Asn Trp Leu Ser Leu Val Tyr Leu Val Val Ser Thr 
65                  70                  75                  80  


Pro Phe Gly Val Ala Ala Ile Trp Ile Leu Asp Ser Val Gly Leu Arg 
                85                  90                  95      


Ala Ala Thr Ile Leu Gly Ala Trp Leu Asn Phe Ala Gly Ser Val Leu 
            100                 105                 110         


Arg Met Val Pro Cys Met Val Val Gly Thr Gln Asn Pro Phe Ala Phe 
        115                 120                 125             


Leu Met Gly Gly Gln Ser Leu Cys Ala Leu Ala Gln Ser Leu Val Ile 
    130                 135                 140                 


Phe Ser Pro Ala Lys Leu Ala Ala Leu Trp Phe Pro Glu His Gln Arg 
145                 150                 155                 160 


Ala Thr Ala Asn Met Leu Ala Thr Met Ser Asn Pro Leu Gly Val Leu 
                165                 170                 175     


Val Ala Asn Val Leu Ser Pro Val Leu Val Lys Lys Gly Glu Asp Ile 
            180                 185                 190         


Pro Leu Met Leu Gly Val Tyr Thr Ile Pro Ala Gly Val Val Cys Leu 
        195                 200                 205             


Leu Ser Thr Ile Cys Leu Trp Glu Ser Val Pro Pro Thr Pro Pro Ser 
    210                 215                 220                 


Ala Gly Ala Ala Ser Ser Thr Ser Glu Lys Phe Leu Asp Gly Leu Lys 
225                 230                 235                 240 


Leu Leu Met Trp Asn Lys Ala Tyr Val Ile Leu Ala Val Cys Leu Gly 
                245                 250                 255     


Gly Met Ile Gly Ile Ser Ala Ser Phe Ser Ala Leu Leu Glu Gln Ile 
            260                 265                 270         


Leu Cys Ala Ser Gly His Ser Ser Gly Phe Ser Gly Leu Cys Gly Ala 
        275                 280                 285             


Leu Phe Ile Thr Phe Gly Ile Leu Gly Ala Leu Ala Leu Gly Pro Tyr 
    290                 295                 300                 


Val Asp Arg Thr Lys His Phe Thr Glu Ala Thr Lys Ile Gly Leu Cys 
305                 310                 315                 320 


Leu Phe Ser Leu Ala Cys Val Pro Phe Ala Leu Val Ser Gln Leu Gln 
                325                 330                 335     


Gly Gln Thr Leu Ala Leu Ala Ala Thr Cys Ser Leu Leu Gly Leu Phe 
            340                 345                 350         


Gly Phe Ser Val Gly Pro Val Ala Met Glu Leu Ala Val Glu Cys Ser 
        355                 360                 365             


Phe Pro Val Gly Glu Gly Ala Ala Thr Gly Met Ile Phe Val Leu Gly 
    370                 375                 380                 


Gln Ala Glu Gly Ile Leu Ile Met Leu Ala Met Thr Ala Leu Thr Val 
385                 390                 395                 400 


Arg Arg Ser Glu Pro Ser Leu Ser Thr Cys Gln Gln Gly Glu Asp Pro 
                405                 410                 415     


Leu Asp Trp Thr Val Ser Leu Leu Leu Met Ala Gly Leu Cys Thr Phe 
            420                 425                 430         


Phe Ser Cys Ile Leu Ala Val Phe Phe His Thr Pro Tyr Arg Arg Leu 
        435                 440                 445             


Gln Ala Glu Ser Gly Glu Pro Pro Ser Thr Arg Asn Ala Val Gly Gly 
    450                 455                 460                 


Ala Asp Ser Gly Pro Gly Val Asp Arg Gly Gly Ala Gly Arg Ala Gly 
465                 470                 475                 480 


Val Leu Gly Pro Ser Thr Ala Thr Pro Glu Cys Thr Ala Arg Gly Ala 
                485                 490                 495     


Ser Leu Glu Asp Pro Arg Gly Pro Gly Ser Pro His Pro Ala Cys His 
            500                 505                 510         


Arg Ala Thr Pro Arg Ala Gln Gly Pro Ala Ala Thr Asp Ala Pro Ser 
        515                 520                 525             


Arg Pro Gly Arg Leu Ala Gly Arg Val Gln Ala Ser Arg Phe Ile Asp 
    530                 535                 540                 


Pro Ala Gly Ser His Ser Ser Phe Ser Ser Pro Trp Val Ile Thr 
545                 550                 555                 


<210>  5309
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  5309

Met Val Ser Ile Pro Glu Tyr Tyr Glu Gly Lys Asn Val Leu Leu Thr 
1               5                   10                  15      


Gly Ala Thr Gly Phe Leu Gly Lys Val Leu Leu Glu Lys Leu Leu Arg 
            20                  25                  30          


Ser Cys Pro Lys Val Asn Ser Val Tyr Val Leu Val Arg Gln Lys Ala 
        35                  40                  45              


Gly Gln Thr Pro Gln Glu Arg Val Glu Glu Val Leu Ser Gly Lys Leu 
    50                  55                  60                  


Phe Asp Arg Leu Arg Asp Glu Asn Pro Asp Phe Arg Glu Lys Ile Ile 
65                  70                  75                  80  


Ala Ile Asn Ser Glu Leu Thr Gln Pro Lys Leu Ala Leu Ser Glu Glu 
                85                  90                  95      


Asp Lys Glu Val Ile Ile Asp Ser Thr Asn Ile Ile Phe His Cys Ala 
            100                 105                 110         


Ala Thr Val Arg Phe Asn Glu Asn Leu Arg Asp Ala Val Gln Leu Asn 
        115                 120                 125             


Val Ile Ala Thr Arg Gln Leu Ile Leu Leu Ala Gln Gln Met Lys Asn 
    130                 135                 140                 


Leu Glu Val Phe Met His Val Ser Thr Ala Tyr Ala Tyr Cys Asn Arg 
145                 150                 155                 160 


Lys His Ile Asp Glu Val Val Tyr Pro Pro Pro Val Asp Pro Lys Lys 
                165                 170                 175     


Leu Ile Asp Ser Leu Glu Trp Met Asp Asp Gly Leu Val Asn Asp Ile 
            180                 185                 190         


Thr Pro Lys Leu Ile Gly Asp Arg Pro Asn Thr Tyr Ile Tyr Thr Lys 
        195                 200                 205             


Ala Leu Ala Glu Tyr Val Val Gln Gln Glu Gly Ala Lys Leu Asn Val 
    210                 215                 220                 


Ala Ile Val Arg Pro Ser Ile Val Gly Ala Ser Trp Lys Glu Pro Phe 
225                 230                 235                 240 


Pro Gly Trp Ile Asp Asn Phe Asn Gly Pro Ser Gly Leu Phe Ile Ala 
                245                 250                 255     


Ala Gly Lys Gly Ile Leu Arg Thr Ile Arg Ala Ser Asn Asn Ala Leu 
            260                 265                 270         


Ala Asp Leu Val Pro Val Asp Val Val Val Asn Met Ser Leu Ala Ala 
        275                 280                 285             


Ala Trp Tyr Ser Gly Val Asn Arg Pro Arg Asn Ile Met Val Tyr Asn 
    290                 295                 300                 


Cys Thr Thr Gly Ser Thr Asn Pro Phe His Trp Gly Glu Val Glu Tyr 
305                 310                 315                 320 


His Val Ile Ser Thr Phe Lys Arg Asn Pro Leu Glu Gln Ala Phe Arg 
                325                 330                 335     


Arg Pro Asn Val Asn Leu Thr Ser Asn His Leu Leu Tyr His Tyr Trp 
            340                 345                 350         


Ile Ala Val Ser His Lys Ala Pro Ala Phe Leu Tyr Asp Ile Tyr Leu 
        355                 360                 365             


Arg Met Thr Gly Arg Ser Pro Arg Met Met Lys Thr Ile Thr Arg Leu 
    370                 375                 380                 


His Lys Ala Met Val Phe Leu Glu Tyr Phe Thr Ser Asn Ser Trp Val 
385                 390                 395                 400 


Trp Asn Thr Glu Asn Val Asn Met Leu Met Asn Gln Leu Asn Pro Glu 
                405                 410                 415     


Asp Lys Lys Thr Phe Asn Ile Asp Val Arg Gln Leu His Trp Ala Glu 
            420                 425                 430         


Tyr Ile Glu Asn Tyr Cys Leu Gly Thr Lys Lys Tyr Val Leu Asn Glu 
        435                 440                 445             


Glu Met Ser Gly Leu Pro Ala Ala Arg Lys His Leu Asn Lys Leu Arg 
    450                 455                 460                 


Asn Ile Arg Tyr Gly Phe Asn Thr Ile Leu Val Ile Leu Ile Trp Arg 
465                 470                 475                 480 


Ile Phe Ile Ala Arg Ser Gln Met Ala Arg Asn Ile Trp Tyr Phe Val 
                485                 490                 495     


Val Ser Leu Cys Tyr Lys Phe Leu Ser Tyr Phe Arg Ala Ser Ser Thr 
            500                 505                 510         


Met Arg Tyr 
        515 


<210>  5310
<211>  841
<212>  PRT
<213>  Homo sapiens

<400>  5310

Met Lys Leu Trp Ile His Leu Phe Tyr Ser Ser Leu Leu Ala Cys Ile 
1               5                   10                  15      


Ser Leu His Ser Gln Thr Pro Val Leu Ser Ser Arg Gly Ser Cys Asp 
            20                  25                  30          


Ser Leu Cys Asn Cys Glu Glu Lys Asp Gly Thr Met Leu Ile Asn Cys 
        35                  40                  45              


Glu Ala Lys Gly Ile Lys Met Val Ser Glu Ile Ser Val Pro Pro Ser 
    50                  55                  60                  


Arg Pro Phe Gln Leu Ser Leu Leu Asn Asn Gly Leu Thr Met Leu His 
65                  70                  75                  80  


Thr Asn Asp Phe Ser Gly Leu Thr Asn Ala Ile Ser Ile His Leu Gly 
                85                  90                  95      


Phe Asn Asn Ile Ala Asp Ile Glu Ile Gly Ala Phe Asn Gly Leu Gly 
            100                 105                 110         


Leu Leu Lys Gln Leu His Ile Asn His Asn Ser Leu Glu Ile Leu Lys 
        115                 120                 125             


Glu Asp Thr Phe His Gly Leu Glu Asn Leu Glu Phe Leu Gln Ala Asp 
    130                 135                 140                 


Asn Asn Phe Ile Thr Val Ile Glu Pro Ser Ala Phe Ser Lys Leu Asn 
145                 150                 155                 160 


Arg Leu Lys Val Leu Ile Leu Asn Asp Asn Ala Ile Glu Ser Leu Pro 
                165                 170                 175     


Pro Asn Ile Phe Arg Phe Val Pro Leu Thr His Leu Asp Leu Arg Gly 
            180                 185                 190         


Asn Gln Leu Gln Thr Leu Pro Tyr Val Gly Phe Leu Glu His Ile Gly 
        195                 200                 205             


Arg Ile Leu Asp Leu Gln Leu Glu Asp Asn Lys Trp Ala Cys Asn Cys 
    210                 215                 220                 


Asp Leu Leu Gln Leu Lys Thr Trp Leu Glu Asn Met Pro Pro Gln Ser 
225                 230                 235                 240 


Ile Ile Gly Asp Val Val Cys Asn Ser Pro Pro Phe Phe Lys Gly Ser 
                245                 250                 255     


Ile Leu Ser Arg Leu Lys Lys Glu Ser Ile Cys Pro Thr Pro Pro Val 
            260                 265                 270         


Tyr Glu Glu His Glu Asp Pro Ser Gly Ser Leu His Leu Ala Ala Thr 
        275                 280                 285             


Ser Ser Ile Asn Asp Ser Arg Met Ser Thr Lys Thr Thr Ser Ile Leu 
    290                 295                 300                 


Lys Leu Pro Thr Lys Ala Pro Gly Leu Ile Pro Tyr Ile Thr Lys Pro 
305                 310                 315                 320 


Ser Thr Gln Leu Pro Gly Pro Tyr Cys Pro Ile Pro Cys Asn Cys Lys 
                325                 330                 335     


Val Leu Ser Pro Ser Gly Leu Leu Ile His Cys Gln Glu Arg Asn Ile 
            340                 345                 350         


Glu Ser Leu Ser Asp Leu Arg Pro Pro Pro Gln Asn Pro Arg Lys Leu 
        355                 360                 365             


Ile Leu Ala Gly Asn Ile Ile His Ser Leu Met Lys Ser Asp Leu Val 
    370                 375                 380                 


Glu Tyr Phe Thr Leu Glu Met Leu His Leu Gly Asn Asn Arg Ile Glu 
385                 390                 395                 400 


Val Leu Glu Glu Gly Ser Phe Met Asn Leu Thr Arg Leu Gln Lys Leu 
                405                 410                 415     


Tyr Leu Asn Gly Asn His Leu Thr Lys Leu Ser Lys Gly Met Phe Leu 
            420                 425                 430         


Gly Leu His Asn Leu Glu Tyr Leu Tyr Leu Glu Tyr Asn Ala Ile Lys 
        435                 440                 445             


Glu Ile Leu Pro Gly Thr Phe Asn Pro Met Pro Lys Leu Lys Val Leu 
    450                 455                 460                 


Tyr Leu Asn Asn Asn Leu Leu Gln Val Leu Pro Pro His Ile Phe Ser 
465                 470                 475                 480 


Gly Val Pro Leu Thr Lys Val Asn Leu Lys Thr Asn Gln Phe Thr His 
                485                 490                 495     


Leu Pro Val Ser Asn Ile Leu Asp Asp Leu Asp Leu Leu Thr Gln Ile 
            500                 505                 510         


Asp Leu Glu Asp Asn Pro Trp Asp Cys Ser Cys Asp Leu Val Gly Leu 
        515                 520                 525             


Gln Gln Trp Ile Gln Lys Leu Ser Lys Asn Thr Val Thr Asp Asp Ile 
    530                 535                 540                 


Leu Cys Thr Ser Pro Gly His Leu Asp Lys Lys Glu Leu Lys Ala Leu 
545                 550                 555                 560 


Asn Ser Glu Ile Leu Cys Pro Gly Leu Val Asn Asn Pro Ser Met Pro 
                565                 570                 575     


Thr Gln Thr Ser Tyr Leu Met Val Thr Thr Pro Ala Thr Thr Thr Asn 
            580                 585                 590         


Thr Ala Asp Thr Ile Leu Arg Ser Leu Thr Asp Ala Val Pro Leu Ser 
        595                 600                 605             


Val Leu Ile Leu Gly Leu Leu Ile Met Phe Ile Thr Ile Val Phe Cys 
    610                 615                 620                 


Ala Ala Gly Ile Val Val Leu Val Leu His Arg Arg Arg Arg Tyr Lys 
625                 630                 635                 640 


Lys Lys Gln Val Asp Glu Gln Met Arg Asp Asn Ser Pro Val His Leu 
                645                 650                 655     


Gln Tyr Ser Met Tyr Gly His Lys Thr Thr His His Thr Thr Glu Arg 
            660                 665                 670         


Pro Ser Ala Ser Leu Tyr Glu Gln His Met Val Ser Pro Met Val His 
        675                 680                 685             


Val Tyr Arg Ser Pro Ser Phe Gly Pro Lys His Leu Glu Glu Glu Glu 
    690                 695                 700                 


Glu Arg Asn Glu Lys Glu Gly Ser Asp Ala Lys His Leu Gln Arg Ser 
705                 710                 715                 720 


Leu Leu Glu Gln Glu Asn His Ser Pro Leu Thr Gly Ser Asn Met Lys 
                725                 730                 735     


Tyr Lys Thr Thr Asn Gln Ser Thr Glu Phe Leu Ser Phe Gln Asp Ala 
            740                 745                 750         


Ser Ser Leu Tyr Arg Asn Ile Leu Glu Lys Glu Arg Glu Leu Gln Gln 
        755                 760                 765             


Leu Gly Ile Thr Glu Tyr Leu Arg Lys Asn Ile Ala Gln Leu Gln Pro 
    770                 775                 780                 


Asp Met Glu Ala His Tyr Pro Gly Ala His Glu Glu Leu Lys Leu Met 
785                 790                 795                 800 


Glu Thr Leu Met Tyr Ser Arg Pro Arg Lys Val Leu Val Glu Gln Thr 
                805                 810                 815     


Lys Asn Glu Tyr Phe Glu Leu Lys Ala Asn Leu His Ala Glu Pro Asp 
            820                 825                 830         


Tyr Leu Glu Val Leu Glu Gln Gln Thr 
        835                 840     


<210>  5311
<211>  1035
<212>  PRT
<213>  Homo sapiens

<400>  5311

Met Ala Pro Arg Leu Gln Leu Glu Lys Ala Ala Trp Arg Trp Ala Glu 
1               5                   10                  15      


Thr Val Arg Pro Glu Glu Val Ser Gln Glu His Ile Glu Thr Ala Tyr 
            20                  25                  30          


Arg Ile Trp Leu Glu Pro Cys Ile Arg Gly Val Cys Arg Arg Asn Cys 
        35                  40                  45              


Lys Gly Asn Pro Asn Cys Leu Val Gly Ile Gly Glu His Ile Trp Leu 
    50                  55                  60                  


Gly Glu Ile Asp Glu Asn Ser Phe His Asn Ile Asp Asp Pro Asn Cys 
65                  70                  75                  80  


Glu Arg Arg Lys Lys Asn Ser Phe Val Gly Leu Thr Asn Leu Gly Ala 
                85                  90                  95      


Thr Cys Tyr Val Asn Thr Phe Leu Gln Val Trp Phe Leu Asn Leu Glu 
            100                 105                 110         


Leu Arg Gln Ala Leu Tyr Leu Cys Pro Ser Thr Cys Ser Asp Tyr Met 
        115                 120                 125             


Leu Gly Asp Gly Ile Gln Glu Glu Lys Asp Tyr Glu Pro Gln Thr Ile 
    130                 135                 140                 


Cys Glu His Leu Gln Tyr Leu Phe Ala Leu Leu Gln Asn Ser Asn Arg 
145                 150                 155                 160 


Arg Tyr Ile Asp Pro Ser Gly Phe Val Lys Ala Leu Gly Leu Asp Thr 
                165                 170                 175     


Gly Gln Gln Gln Asp Ala Gln Glu Phe Ser Lys Leu Phe Met Ser Leu 
            180                 185                 190         


Leu Glu Asp Thr Leu Ser Lys Gln Lys Asn Pro Asp Val Arg Asn Ile 
        195                 200                 205             


Val Gln Gln Gln Phe Cys Gly Glu Tyr Ala Tyr Val Thr Val Cys Asn 
    210                 215                 220                 


Gln Cys Gly Arg Glu Ser Lys Leu Leu Ser Lys Phe Tyr Glu Leu Glu 
225                 230                 235                 240 


Leu Asn Ile Gln Gly His Lys Gln Leu Thr Asp Cys Ile Ser Glu Phe 
                245                 250                 255     


Leu Lys Glu Glu Lys Leu Glu Gly Asp Asn Arg Tyr Phe Cys Glu Asn 
            260                 265                 270         


Cys Gln Ser Lys Gln Asn Ala Thr Arg Lys Ile Arg Leu Leu Ser Leu 
        275                 280                 285             


Pro Cys Thr Leu Asn Leu Gln Leu Met Arg Phe Val Phe Asp Arg Gln 
    290                 295                 300                 


Thr Gly His Lys Lys Lys Leu Asn Thr Tyr Ile Gly Phe Ser Glu Ile 
305                 310                 315                 320 


Leu Asp Met Glu Pro Tyr Val Glu His Lys Gly Gly Ser Tyr Val Tyr 
                325                 330                 335     


Glu Leu Ser Ala Val Leu Ile His Arg Gly Val Ser Ala Tyr Ser Gly 
            340                 345                 350         


His Tyr Ile Ala His Val Lys Asp Pro Gln Ser Gly Glu Trp Tyr Lys 
        355                 360                 365             


Phe Asn Asp Glu Asp Ile Glu Lys Met Glu Gly Lys Lys Leu Gln Leu 
    370                 375                 380                 


Gly Ile Glu Glu Asp Leu Ala Glu Pro Ser Lys Ser Gln Thr Arg Lys 
385                 390                 395                 400 


Pro Lys Cys Gly Lys Gly Thr His Cys Ser Arg Asn Ala Tyr Met Leu 
                405                 410                 415     


Val Tyr Arg Leu Gln Thr Gln Glu Lys Pro Asn Thr Thr Val Gln Val 
            420                 425                 430         


Pro Ala Phe Leu Gln Glu Leu Val Asp Arg Asp Asn Ser Lys Phe Glu 
        435                 440                 445             


Glu Trp Cys Ile Glu Met Ala Glu Met Arg Lys Gln Ser Val Asp Lys 
    450                 455                 460                 


Gly Lys Ala Lys His Glu Glu Val Lys Glu Leu Tyr Gln Arg Leu Pro 
465                 470                 475                 480 


Ala Gly Ala Glu Pro Tyr Glu Phe Val Ser Leu Glu Trp Leu Gln Lys 
                485                 490                 495     


Trp Leu Asp Glu Ser Thr Pro Thr Lys Pro Ile Asp Asn His Ala Cys 
            500                 505                 510         


Leu Cys Ser His Asp Lys Leu His Pro Asp Lys Ile Ser Ile Met Lys 
        515                 520                 525             


Arg Ile Ser Glu Tyr Ala Ala Asp Ile Phe Tyr Ser Arg Tyr Gly Gly 
    530                 535                 540                 


Gly Pro Arg Leu Thr Val Lys Ala Leu Cys Lys Glu Cys Val Val Glu 
545                 550                 555                 560 


Arg Cys Arg Ile Leu Arg Leu Lys Asn Gln Leu Asn Glu Asp Tyr Lys 
                565                 570                 575     


Thr Val Asn Asn Leu Leu Lys Ala Ala Val Lys Gly Ser Asp Gly Phe 
            580                 585                 590         


Trp Val Gly Lys Ser Ser Leu Arg Ser Trp Arg Gln Leu Ala Leu Glu 
        595                 600                 605             


Gln Leu Asp Glu Gln Asp Gly Asp Ala Glu Gln Ser Asn Gly Lys Met 
    610                 615                 620                 


Asn Gly Ser Thr Leu Asn Lys Asp Glu Ser Lys Glu Glu Arg Lys Glu 
625                 630                 635                 640 


Glu Glu Glu Leu Asn Phe Asn Glu Asp Ile Leu Cys Pro His Gly Glu 
                645                 650                 655     


Leu Cys Ile Ser Glu Asn Glu Arg Arg Leu Val Ser Lys Glu Ala Trp 
            660                 665                 670         


Ser Lys Leu Gln Gln Tyr Phe Pro Lys Ala Pro Glu Phe Pro Ser Tyr 
        675                 680                 685             


Lys Glu Cys Cys Ser Gln Cys Lys Ile Leu Glu Arg Glu Gly Glu Glu 
    690                 695                 700                 


Asn Glu Ala Leu His Lys Met Ile Ala Asn Glu Gln Lys Thr Ser Leu 
705                 710                 715                 720 


Pro Asn Leu Phe Gln Asp Lys Asn Arg Pro Cys Leu Ser Asn Trp Pro 
                725                 730                 735     


Glu Asp Thr Asp Val Leu Tyr Ile Val Ser Gln Phe Phe Val Glu Glu 
            740                 745                 750         


Trp Arg Lys Phe Val Arg Lys Pro Thr Arg Cys Ser Pro Val Ser Ser 
        755                 760                 765             


Val Gly Asn Ser Ala Leu Leu Cys Pro His Gly Gly Leu Met Phe Thr 
    770                 775                 780                 


Phe Ala Ser Met Thr Lys Glu Asp Ser Lys Leu Ile Ala Leu Ile Trp 
785                 790                 795                 800 


Pro Ser Glu Trp Gln Met Ile Gln Lys Leu Phe Val Val Asp His Val 
                805                 810                 815     


Ile Lys Ile Thr Arg Ile Glu Val Gly Asp Val Asn Pro Ser Glu Thr 
            820                 825                 830         


Gln Tyr Ile Ser Glu Pro Lys Leu Cys Pro Glu Cys Arg Glu Gly Leu 
        835                 840                 845             


Leu Cys Gln Gln Gln Arg Asp Leu Arg Glu Tyr Thr Gln Ala Thr Ile 
    850                 855                 860                 


Tyr Val His Lys Val Val Asp Asn Lys Lys Val Met Lys Asp Ser Ala 
865                 870                 875                 880 


Pro Glu Leu Asn Val Ser Ser Ser Glu Thr Glu Glu Asp Lys Glu Glu 
                885                 890                 895     


Ala Lys Pro Asp Gly Glu Lys Asp Pro Asp Phe Asn Gln Ser Asn Gly 
            900                 905                 910         


Gly Thr Lys Arg Gln Lys Ile Ser His Gln Asn Tyr Ile Ala Tyr Gln 
        915                 920                 925             


Lys Gln Val Ile Arg Arg Ser Met Arg His Arg Lys Val Arg Gly Glu 
    930                 935                 940                 


Lys Ala Leu Leu Val Ser Ala Asn Gln Thr Leu Lys Glu Leu Lys Ile 
945                 950                 955                 960 


Gln Ile Met His Ala Phe Ser Val Ala Pro Phe Asp Gln Asn Leu Ser 
                965                 970                 975     


Ile Asp Gly Lys Ile Leu Ser Asp Asp Cys Ala Thr Leu Gly Thr Leu 
            980                 985                 990         


Gly Val Ile Pro Glu Ser Val Ile  Leu Leu Lys Ala Asp  Glu Pro Ile 
        995                 1000                 1005             


Ala Asp  Tyr Ala Ala Met Asp  Asp Val Met Gln Val  Cys Met Pro 
    1010                 1015                 1020             


Glu Glu  Gly Phe Lys Gly Thr  Gly Leu Leu Gly His  
    1025                 1030                 1035 


<210>  5312
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  5312

Met Glu Lys Gln Pro Gln Asn Ser Arg Arg Gly Leu Ala Pro Arg Glu 
1               5                   10                  15      


Val Pro Pro Ala Val Gly Leu Leu Leu Ile Met Ala Leu Met Asn Thr 
            20                  25                  30          


Leu Leu Tyr Leu Cys Leu Asp His Phe Phe Ile Ala Pro Arg Gln Ser 
        35                  40                  45              


Thr Val Asp Pro Thr His Cys Pro Tyr Gly His Phe Arg Ile Gly Gln 
    50                  55                  60                  


Met Lys Asn Cys Ser Pro Trp Leu Ser Cys Glu Glu Leu Arg Thr Glu 
65                  70                  75                  80  


Val Arg Gln Leu Lys Arg Val Gly Glu Gly Ala Val Lys Arg Val Phe 
                85                  90                  95      


Leu Ser Glu Trp Lys Glu His Lys Val Ala Leu Ser Gln Leu Thr Ser 
            100                 105                 110         


Leu Glu Met Lys Asp Asp Phe Leu His Gly Leu Gln Met Leu Lys Ser 
        115                 120                 125             


Leu Gln Gly Thr His Val Val Thr Leu Leu Gly Tyr Cys Glu Asp Asp 
    130                 135                 140                 


Asn Thr Met Leu Thr Glu Tyr His Pro Leu Gly Ser Leu Ser Asn Leu 
145                 150                 155                 160 


Glu Glu Thr Leu Asn Leu Ser Lys Tyr Gln Asn Val Asn Thr Trp Gln 
                165                 170                 175     


His Arg Leu Glu Leu Ala Met Asp Tyr Val Ser Ile Ile Asn Tyr Leu 
            180                 185                 190         


His His Ser Pro Val Gly Thr Arg Val Met Cys Asp Ser Asn Asp Leu 
        195                 200                 205             


Pro Lys Thr Leu Ser Gln Tyr Leu Leu Thr Ser Asn Phe Ser Ile Leu 
    210                 215                 220                 


Ala Asn Asp Leu Asp Ala Leu Pro Leu Val Asn His Ser Ser Gly Met 
225                 230                 235                 240 


Leu Val Lys Cys Gly His Arg Glu Leu His Gly Asp Phe Val Ala Pro 
                245                 250                 255     


Glu Gln Leu Trp Pro Tyr Gly Glu Asp Val Pro Phe His Asp Asp Leu 
            260                 265                 270         


Met Pro Ser Tyr Asp Glu Lys Ile Asp Ile Trp Lys Ile Pro Asp Ile 
        275                 280                 285             


Ser Ser Phe Leu Leu Gly His Ile Glu Gly Ser Asp Met Val Arg Phe 
    290                 295                 300                 


His Leu Phe Asp Ile His Lys Ala Cys Lys Ser Gln Thr Pro Ser Glu 
305                 310                 315                 320 


Arg Pro Thr Ala Gln Asp Val Leu Glu Thr Tyr Gln Lys Val Leu Asp 
                325                 330                 335     


Thr Leu Arg Asp Ala Met Met Ser Gln Ala Arg Glu Met Leu 
            340                 345                 350 


<210>  5313
<211>  1896
<212>  PRT
<213>  Homo sapiens

<400>  5313

Met Pro Leu Pro Pro Arg Ser Leu Gln Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Pro Gly Met Trp Ala Glu Ala Gly Leu Pro Arg 
            20                  25                  30          


Ala Gly Gly Gly Ser Gln Pro Pro Phe Arg Thr Phe Ser Ala Ser Asp 
        35                  40                  45              


Trp Gly Leu Thr His Leu Val Val His Glu Gln Thr Gly Glu Val Tyr 
    50                  55                  60                  


Val Gly Ala Val Asn Arg Ile Tyr Lys Leu Ser Gly Asn Leu Thr Leu 
65                  70                  75                  80  


Leu Arg Ala His Val Thr Gly Pro Val Glu Asp Asn Glu Lys Cys Tyr 
                85                  90                  95      


Pro Pro Pro Ser Val Gln Ser Cys Pro His Gly Leu Gly Ser Thr Asp 
            100                 105                 110         


Asn Val Asn Lys Leu Leu Leu Leu Asp Tyr Ala Ala Asn Arg Leu Leu 
        115                 120                 125             


Ala Cys Gly Ser Ala Ser Gln Gly Ile Cys Gln Phe Leu Arg Leu Asp 
    130                 135                 140                 


Asp Leu Phe Lys Leu Gly Glu Pro His His Arg Lys Glu His Tyr Leu 
145                 150                 155                 160 


Ser Ser Val Gln Glu Ala Gly Ser Met Ala Gly Val Leu Ile Ala Gly 
                165                 170                 175     


Pro Pro Gly Gln Gly Gln Ala Lys Leu Phe Val Gly Thr Pro Ile Asp 
            180                 185                 190         


Gly Lys Ser Glu Tyr Phe Pro Thr Leu Ser Ser Arg Arg Leu Met Ala 
        195                 200                 205             


Asn Glu Glu Asp Ala Asp Met Phe Gly Phe Val Tyr Gln Asp Glu Phe 
    210                 215                 220                 


Val Ser Ser Gln Leu Lys Ile Pro Ser Asp Thr Leu Ser Lys Phe Pro 
225                 230                 235                 240 


Ala Phe Asp Ile Tyr Tyr Val Tyr Ser Phe Arg Ser Glu Gln Phe Val 
                245                 250                 255     


Tyr Tyr Leu Thr Leu Gln Leu Asp Thr Gln Leu Thr Ser Pro Asp Ala 
            260                 265                 270         


Ala Gly Glu His Phe Phe Thr Ser Lys Ile Val Arg Leu Cys Val Asp 
        275                 280                 285             


Asp Pro Lys Phe Tyr Ser Tyr Val Glu Phe Pro Ile Gly Cys Glu Gln 
    290                 295                 300                 


Ala Gly Val Glu Tyr Arg Leu Val Gln Asp Ala Tyr Leu Ser Arg Pro 
305                 310                 315                 320 


Gly Arg Ala Leu Ala His Gln Leu Gly Leu Ala Glu Asp Glu Asp Val 
                325                 330                 335     


Leu Phe Thr Val Phe Ala Gln Gly Gln Lys Asn Arg Val Lys Pro Pro 
            340                 345                 350         


Lys Glu Ser Ala Leu Cys Leu Phe Thr Leu Arg Ala Ile Lys Glu Lys 
        355                 360                 365             


Ile Lys Glu Arg Ile Gln Ser Cys Tyr Arg Gly Glu Gly Lys Leu Ser 
    370                 375                 380                 


Leu Pro Trp Leu Leu Asn Lys Glu Leu Gly Cys Ile Asn Ser Pro Leu 
385                 390                 395                 400 


Gln Ile Asp Asp Asp Phe Cys Gly Gln Asp Phe Asn Gln Pro Leu Gly 
                405                 410                 415     


Gly Thr Val Thr Ile Glu Gly Thr Pro Leu Phe Val Asp Lys Asp Asp 
            420                 425                 430         


Gly Leu Thr Ala Val Ala Ala Tyr Asp Tyr Arg Gly Arg Thr Val Val 
        435                 440                 445             


Phe Ala Gly Thr Arg Ser Gly Arg Ile Arg Lys Ile Leu Val Asp Leu 
    450                 455                 460                 


Ser Asn Pro Gly Gly Arg Pro Ala Leu Ala Tyr Glu Ser Val Val Ala 
465                 470                 475                 480 


Gln Glu Gly Ser Pro Ile Leu Arg Asp Leu Val Leu Ser Pro Asn His 
                485                 490                 495     


Gln Tyr Leu Tyr Ala Met Thr Glu Lys Gln Val Thr Arg Val Pro Val 
            500                 505                 510         


Glu Ser Cys Val Gln Tyr Thr Ser Cys Glu Leu Cys Leu Gly Ser Arg 
        515                 520                 525             


Asp Pro His Cys Gly Trp Cys Val Leu His Ser Ile Cys Ser Arg Arg 
    530                 535                 540                 


Asp Ala Cys Glu Arg Ala Asp Glu Pro Gln Arg Phe Ala Ala Asp Leu 
545                 550                 555                 560 


Leu Gln Cys Val Gln Leu Thr Val Gln Pro Arg Asn Val Ser Val Thr 
                565                 570                 575     


Met Ser Gln Val Pro Leu Val Leu Gln Ala Trp Asn Val Pro Asp Leu 
            580                 585                 590         


Ser Ala Gly Val Asn Cys Ser Phe Glu Asp Phe Thr Glu Ser Glu Ser 
        595                 600                 605             


Val Leu Glu Asp Gly Arg Ile His Cys Arg Ser Pro Ser Ala Arg Glu 
    610                 615                 620                 


Val Ala Pro Ile Thr Arg Gly Gln Gly Asp Gln Arg Val Val Lys Leu 
625                 630                 635                 640 


Tyr Leu Lys Ser Lys Glu Thr Gly Lys Lys Phe Ala Ser Val Asp Phe 
                645                 650                 655     


Val Phe Tyr Asn Cys Ser Val His Gln Ser Cys Leu Ser Cys Val Asn 
            660                 665                 670         


Gly Ser Phe Pro Cys His Trp Cys Lys Tyr Arg His Val Cys Thr His 
        675                 680                 685             


Asn Val Ala Asp Cys Ala Phe Leu Glu Gly Arg Val Asn Val Ser Glu 
    690                 695                 700                 


Asp Cys Pro Gln Ile Leu Pro Ser Thr Gln Ile Tyr Val Pro Val Gly 
705                 710                 715                 720 


Val Val Lys Pro Ile Thr Leu Ala Ala Arg Asn Leu Pro Gln Pro Gln 
                725                 730                 735     


Ser Gly Gln Arg Gly Tyr Glu Cys Leu Phe His Ile Pro Gly Ser Pro 
            740                 745                 750         


Ala Arg Val Thr Ala Leu Arg Phe Asn Ser Ser Ser Leu Gln Cys Gln 
        755                 760                 765             


Asn Ser Ser Tyr Ser Tyr Glu Gly Asn Asp Val Ser Asp Leu Pro Val 
    770                 775                 780                 


Asn Leu Ser Val Val Trp Asn Gly Asn Phe Val Ile Asp Asn Pro Gln 
785                 790                 795                 800 


Asn Ile Gln Ala His Leu Tyr Lys Cys Pro Ala Leu Arg Glu Ser Cys 
                805                 810                 815     


Gly Leu Cys Leu Lys Ala Asp Pro Arg Phe Glu Cys Gly Trp Cys Val 
            820                 825                 830         


Ala Glu Arg Arg Cys Ser Leu Arg His His Cys Ala Ala Asp Thr Pro 
        835                 840                 845             


Ala Ser Trp Met His Ala Arg His Gly Ser Ser Arg Cys Thr Asp Pro 
    850                 855                 860                 


Lys Ile Leu Lys Leu Ser Pro Glu Thr Gly Pro Arg Gln Gly Gly Thr 
865                 870                 875                 880 


Arg Leu Thr Ile Thr Gly Glu Asn Leu Gly Leu Arg Phe Glu Asp Val 
                885                 890                 895     


Arg Leu Gly Val Arg Val Gly Lys Val Leu Cys Ser Pro Val Glu Ser 
            900                 905                 910         


Glu Tyr Ile Ser Ala Glu Gln Ile Val Cys Glu Ile Gly Asp Ala Ser 
        915                 920                 925             


Ser Val Arg Ala His Asp Ala Leu Val Glu Val Cys Val Arg Asp Cys 
    930                 935                 940                 


Ser Pro His Tyr Arg Ala Leu Ser Pro Lys Arg Phe Thr Phe Val Thr 
945                 950                 955                 960 


Pro Thr Phe Tyr Arg Val Ser Pro Ser Arg Gly Pro Leu Ser Gly Gly 
                965                 970                 975     


Thr Trp Ile Gly Ile Glu Gly Ser His Leu Asn Ala Gly Ser Asp Val 
            980                 985                 990         


Ala Val Ser Val Gly Gly Arg Pro  Cys Ser Phe Ser Trp  Arg Asn Ser 
        995                 1000                 1005             


Arg Glu  Ile Arg Cys Leu Thr  Pro Pro Gly Gln Ser  Pro Gly Ser 
    1010                 1015                 1020             


Ala Pro  Ile Ile Ile Asn Ile  Asn Arg Ala Gln Leu  Thr Asn Pro 
    1025                 1030                 1035             


Glu Val  Lys Tyr Asn Tyr Thr  Glu Asp Pro Thr Ile  Leu Arg Ile 
    1040                 1045                 1050             


Asp Pro  Glu Trp Ser Ile Asn  Ser Gly Gly Thr Leu  Leu Thr Val 
    1055                 1060                 1065             


Thr Gly  Thr Asn Leu Ala Thr  Val Arg Glu Pro Arg  Ile Arg Ala 
    1070                 1075                 1080             


Lys Tyr  Gly Gly Ile Glu Arg  Glu Asn Gly Cys Leu  Val Tyr Asn 
    1085                 1090                 1095             


Asp Thr  Thr Met Val Cys Arg  Ala Pro Ser Val Ala  Asn Pro Val 
    1100                 1105                 1110             


Arg Ser  Pro Pro Glu Leu Gly  Glu Arg Pro Asp Glu  Leu Gly Phe 
    1115                 1120                 1125             


Val Met  Asp Asn Val Arg Ser  Leu Leu Val Leu Asn  Ser Thr Ser 
    1130                 1135                 1140             


Phe Leu  Tyr Tyr Pro Asp Pro  Val Leu Glu Pro Leu  Ser Pro Thr 
    1145                 1150                 1155             


Gly Leu  Leu Glu Leu Lys Pro  Ser Ser Pro Leu Ile  Leu Lys Gly 
    1160                 1165                 1170             


Arg Asn  Leu Leu Pro Pro Ala  Pro Gly Asn Ser Arg  Leu Asn Tyr 
    1175                 1180                 1185             


Thr Val  Leu Ile Gly Ser Thr  Pro Cys Thr Leu Thr  Val Ser Glu 
    1190                 1195                 1200             


Thr Gln  Leu Leu Cys Glu Ala  Pro Asn Leu Thr Gly  Gln His Lys 
    1205                 1210                 1215             


Val Thr  Val Arg Ala Gly Gly  Phe Glu Phe Ser Pro  Gly Thr Leu 
    1220                 1225                 1230             


Gln Val  Tyr Ser Asp Ser Leu  Leu Thr Leu Pro Ala  Ile Val Gly 
    1235                 1240                 1245             


Ile Gly  Gly Gly Gly Gly Leu  Leu Leu Leu Val Ile  Val Ala Val 
    1250                 1255                 1260             


Leu Ile  Ala Tyr Lys Arg Lys  Ser Arg Asp Ala Asp  Arg Thr Leu 
    1265                 1270                 1275             


Lys Arg  Leu Gln Leu Gln Met  Asp Asn Leu Glu Ser  Arg Val Ala 
    1280                 1285                 1290             


Leu Glu  Cys Lys Glu Ala Phe  Ala Glu Leu Gln Thr  Asp Ile His 
    1295                 1300                 1305             


Glu Leu  Thr Asn Asp Leu Asp  Gly Ala Gly Ile Pro  Phe Leu Asp 
    1310                 1315                 1320             


Tyr Arg  Thr Tyr Ala Met Arg  Val Leu Phe Pro Gly  Ile Glu Asp 
    1325                 1330                 1335             


His Pro  Val Leu Lys Glu Met  Glu Val Gln Ala Asn  Val Glu Lys 
    1340                 1345                 1350             


Ser Leu  Thr Leu Phe Gly Gln  Leu Leu Thr Lys Lys  His Phe Leu 
    1355                 1360                 1365             


Leu Thr  Phe Ile Arg Thr Leu  Glu Ala Gln Arg Ser  Phe Ser Met 
    1370                 1375                 1380             


Arg Asp  Arg Gly Asn Val Ala  Ser Leu Ile Met Thr  Ala Leu Gln 
    1385                 1390                 1395             


Gly Glu  Met Glu Tyr Ala Thr  Gly Val Leu Lys Gln  Leu Leu Ser 
    1400                 1405                 1410             


Asp Leu  Ile Glu Lys Asn Leu  Glu Ser Lys Asn His  Pro Lys Leu 
    1415                 1420                 1425             


Leu Leu  Arg Arg Thr Glu Ser  Val Ala Glu Lys Met  Leu Thr Asn 
    1430                 1435                 1440             


Trp Phe  Thr Phe Leu Leu Tyr  Lys Phe Leu Lys Glu  Cys Ala Gly 
    1445                 1450                 1455             


Glu Pro  Leu Phe Met Leu Tyr  Cys Ala Ile Lys Gln  Gln Met Glu 
    1460                 1465                 1470             


Lys Gly  Pro Ile Asp Ala Ile  Thr Gly Glu Ala Arg  Tyr Ser Leu 
    1475                 1480                 1485             


Ser Glu  Asp Lys Leu Ile Arg  Gln Gln Ile Asp Tyr  Lys Thr Leu 
    1490                 1495                 1500             


Thr Leu  Asn Cys Val Asn Pro  Glu Asn Glu Asn Ala  Pro Glu Val 
    1505                 1510                 1515             


Pro Val  Lys Gly Leu Asp Cys  Asp Thr Val Thr Gln  Ala Lys Glu 
    1520                 1525                 1530             


Lys Leu  Leu Asp Ala Ala Tyr  Lys Gly Val Pro Tyr  Ser Gln Arg 
    1535                 1540                 1545             


Pro Lys  Ala Ala Asp Met Asp  Leu Glu Trp Arg Gln  Gly Arg Met 
    1550                 1555                 1560             


Ala Arg  Ile Ile Leu Gln Asp  Glu Asp Val Thr Thr  Lys Ile Asp 
    1565                 1570                 1575             


Asn Asp  Trp Lys Arg Leu Asn  Thr Leu Ala His Tyr  Gln Val Thr 
    1580                 1585                 1590             


Asp Gly  Ser Ser Val Ala Leu  Val Pro Lys Gln Thr  Ser Ala Tyr 
    1595                 1600                 1605             


Asn Ile  Ser Asn Ser Ser Thr  Phe Thr Lys Ser Leu  Ser Arg Tyr 
    1610                 1615                 1620             


Glu Ser  Met Leu Arg Thr Ala  Ser Ser Pro Asp Ser  Leu Arg Ser 
    1625                 1630                 1635             


Arg Thr  Pro Met Ile Thr Pro  Asp Leu Glu Ser Gly  Thr Lys Leu 
    1640                 1645                 1650             


Trp His  Leu Val Lys Asn His  Asp His Leu Asp Gln  Arg Glu Gly 
    1655                 1660                 1665             


Asp Arg  Gly Ser Lys Met Val  Ser Glu Ile Tyr Leu  Thr Arg Leu 
    1670                 1675                 1680             


Leu Ala  Thr Lys Gly Thr Leu  Gln Lys Phe Val Asp  Asp Leu Phe 
    1685                 1690                 1695             


Glu Thr  Ile Phe Ser Thr Ala  His Arg Gly Ser Ala  Leu Pro Leu 
    1700                 1705                 1710             


Ala Ile  Lys Tyr Met Phe Asp  Phe Leu Asp Glu Gln  Ala Asp Lys 
    1715                 1720                 1725             


His Gln  Ile His Asp Ala Asp  Val Arg His Thr Trp  Lys Ser Asn 
    1730                 1735                 1740             


Cys Leu  Pro Leu Arg Phe Trp  Val Asn Val Ile Lys  Asn Pro Gln 
    1745                 1750                 1755             


Phe Val  Phe Asp Ile His Lys  Asn Ser Ile Thr Asp  Ala Cys Leu 
    1760                 1765                 1770             


Ser Val  Val Ala Gln Thr Phe  Met Asp Ser Cys Ser  Thr Ser Glu 
    1775                 1780                 1785             


His Lys  Leu Gly Lys Asp Ser  Pro Ser Asn Lys Leu  Leu Tyr Ala 
    1790                 1795                 1800             


Lys Asp  Ile Pro Asn Tyr Lys  Ser Trp Val Glu Arg  Tyr Tyr Ala 
    1805                 1810                 1815             


Asp Ile  Ala Lys Met Pro Ala  Ile Ser Asp Gln Asp  Met Ser Ala 
    1820                 1825                 1830             


Tyr Leu  Ala Glu Gln Ser Arg  Leu His Leu Ser Gln  Phe Asn Ser 
    1835                 1840                 1845             


Met Ser  Ala Leu His Glu Ile  Tyr Ser Tyr Ile Thr  Lys Tyr Lys 
    1850                 1855                 1860             


Asp Glu  Ile Leu Ala Ala Leu  Glu Lys Asp Glu Gln  Ala Arg Arg 
    1865                 1870                 1875             


Gln Arg  Leu Arg Ser Lys Leu  Glu Gln Val Val Asp  Thr Met Ala 
    1880                 1885                 1890             


Leu Ser  Ser 
    1895     


<210>  5314
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  5314

Met Gly Lys Asp Phe Arg Tyr Tyr Phe Gln His Pro Trp Ser Arg Met 
1               5                   10                  15      


Ile Val Ala Tyr Leu Val Ile Phe Phe Asn Phe Leu Ile Phe Ala Glu 
            20                  25                  30          


Asp Pro Val Ser His Ser Gln Thr Glu Ala Asn Val Ile Val Val Gly 
        35                  40                  45              


Asn Cys Phe Ser Phe Val Thr Asn Lys Tyr Pro Arg Gly Val Gly Trp 
    50                  55                  60                  


Arg Ile Leu Lys Val Leu Leu Trp Leu Leu Ala Ile Leu Thr Gly Leu 
65                  70                  75                  80  


Ile Ala Gly Lys Phe Leu Phe His Gln Arg Leu Phe Gly Gln Leu Leu 
                85                  90                  95      


Arg Leu Lys Met Phe Arg Glu Asp His Gly Ser Trp Met Thr Met Phe 
            100                 105                 110         


Phe Ser Thr Ile Leu Phe Leu Phe Ile Phe Ser His Ile Tyr Asn Thr 
        115                 120                 125             


Ile Leu Leu Met Asp Gly Asn Met Gly Ala Tyr Ile Ile Thr Asp Tyr 
    130                 135                 140                 


Met Gly Ile Arg Asn Glu Ser Phe Met Lys Leu Ala Ala Val Gly Thr 
145                 150                 155                 160 


Trp Met Gly Asp Phe Val Thr Ala Trp Met Val Thr Asp Met Met Leu 
                165                 170                 175     


Gln Asp Lys Pro Tyr Pro Asp Trp Gly Lys Ser Ala Arg Ala Phe Trp 
            180                 185                 190         


Lys Lys Gly Asn Val Arg Ile Thr Leu Phe Trp Thr Val Leu Phe Thr 
        195                 200                 205             


Leu Thr Ser Val Val Val Leu Val Ile Thr Thr Asp Trp Ile Ser Trp 
    210                 215                 220                 


Asp Lys Leu Asn Arg Gly Phe Leu Pro Ser Asp Glu Val Ser Arg Ala 
225                 230                 235                 240 


Phe Leu Ala Ser Phe Ile Leu Val Phe Asp Leu Leu Ile Val Met Gln 
                245                 250                 255     


Asp Trp Glu Phe Pro His Phe Met Gly Asp Val Asp Val Asn Leu Pro 
            260                 265                 270         


Gly Leu His Thr Pro His Met Gln Phe Lys Ile Pro Phe Phe Gln Lys 
        275                 280                 285             


Ile Phe Lys Glu Glu Tyr Arg Ile His Ile Thr Gly Lys Trp Phe Asn 
    290                 295                 300                 


Tyr Gly Ile Ile Phe Leu Val Leu Ile Leu Asp Leu Asn Met Trp Lys 
305                 310                 315                 320 


Asn Gln Ile Phe Tyr Lys Pro His Glu Tyr Gly Gln Tyr Ile Gly Pro 
                325                 330                 335     


Gly Gln Lys Ile Tyr Thr Val Lys Asp Ser Glu Ser Leu Lys Asp Leu 
            340                 345                 350         


Asn Arg Thr Lys Leu Ser Trp Glu Trp Arg Ser Asn His Thr Asn Pro 
        355                 360                 365             


Arg Thr Asn Lys Thr Tyr Val Glu Gly Asp Met Phe Leu His Ser Arg 
    370                 375                 380                 


Phe Ile Gly Ala Ser Leu Asp Val Lys Cys Leu Ala Phe Val Pro Ser 
385                 390                 395                 400 


Leu Ile Ala Phe Val Trp Phe Gly Phe Phe Ile Trp Phe Phe Gly Arg 
                405                 410                 415     


Phe Leu Lys Asn Glu Pro Arg Met Glu Asn Gln Asp Lys Thr Tyr Thr 
            420                 425                 430         


Arg Met Lys Arg Lys Ser Pro Ser Glu His Ser Lys Asp Met Gly Ile 
        435                 440                 445             


Thr Arg Glu Asn Thr Gln Ala Ser Val Glu Asp Pro Leu Asn Asp Pro 
    450                 455                 460                 


Ser Leu Val Cys Ile Arg Ser Asp Phe Asn Glu Ile Val Tyr Lys Ser 
465                 470                 475                 480 


Ser His Leu Thr Ser Glu Asn Leu Ser Ser Gln Leu Asn Glu Ser Thr 
                485                 490                 495     


Ser Ala Thr Glu Ala Asp Gln Asp Pro Thr Thr Ser Lys Ser Thr Pro 
            500                 505                 510         


Thr Asn 
        


<210>  5315
<211>  803
<212>  PRT
<213>  Homo sapiens

<400>  5315

Met Ile Pro Val Thr Glu Phe Arg Gln Phe Ser Glu Gln Gln Pro Ala 
1               5                   10                  15      


Phe Arg Val Leu Lys Pro Trp Trp Asp Val Phe Thr Asp Tyr Leu Ser 
            20                  25                  30          


Val Ala Met Leu Met Ile Gly Val Phe Gly Cys Thr Leu Gln Val Met 
        35                  40                  45              


Gln Asp Lys Ile Ile Cys Leu Pro Lys Arg Val Gln Pro Ala Gln Asn 
    50                  55                  60                  


His Ser Ser Leu Ser Asn Val Ser Gln Ala Val Ala Ser Thr Thr Pro 
65                  70                  75                  80  


Leu Pro Pro Pro Lys Pro Ser Pro Ala Asn Pro Ile Thr Val Glu Met 
                85                  90                  95      


Lys Gly Leu Lys Thr Asp Leu Asp Leu Gln Gln Tyr Ser Phe Ile Asn 
            100                 105                 110         


Gln Met Cys Tyr Glu Arg Ala Leu His Trp Tyr Ala Lys Tyr Phe Pro 
        115                 120                 125             


Tyr Leu Val Leu Ile His Thr Leu Val Phe Met Leu Cys Ser Asn Phe 
    130                 135                 140                 


Trp Phe Lys Phe Pro Gly Ser Ser Ser Lys Ile Glu His Phe Ile Ser 
145                 150                 155                 160 


Ile Leu Gly Lys Cys Phe Asp Ser Pro Trp Thr Thr Arg Ala Leu Ser 
                165                 170                 175     


Glu Val Ser Gly Glu Asp Ser Glu Glu Lys Asp Asn Arg Lys Asn Asn 
            180                 185                 190         


Met Asn Arg Ser Asn Thr Ile Gln Ser Gly Pro Glu Gly Ser Leu Val 
        195                 200                 205             


Asn Ser Gln Ser Leu Lys Ser Ile Pro Glu Lys Phe Val Val Asp Lys 
    210                 215                 220                 


Ser Thr Ala Gly Ala Leu Asp Lys Lys Glu Gly Glu Gln Ala Lys Ala 
225                 230                 235                 240 


Leu Phe Glu Lys Val Lys Lys Phe Arg Leu His Val Glu Glu Gly Asp 
                245                 250                 255     


Ile Leu Tyr Ala Met Tyr Val Arg Gln Thr Val Leu Lys Val Ile Lys 
            260                 265                 270         


Phe Leu Ile Ile Ile Ala Tyr Asn Ser Ala Leu Val Ser Lys Val Gln 
        275                 280                 285             


Phe Thr Val Asp Cys Asn Val Asp Ile Gln Asp Met Thr Gly Tyr Lys 
    290                 295                 300                 


Asn Phe Ser Cys Asn His Thr Met Ala His Leu Phe Ser Lys Leu Ser 
305                 310                 315                 320 


Phe Cys Tyr Leu Cys Phe Val Ser Ile Tyr Gly Leu Thr Cys Leu Tyr 
                325                 330                 335     


Thr Leu Tyr Trp Leu Phe Tyr Arg Ser Leu Arg Glu Tyr Ser Phe Glu 
            340                 345                 350         


Tyr Val Arg Gln Glu Thr Gly Ile Asp Asp Ile Pro Asp Val Lys Asn 
        355                 360                 365             


Asp Phe Ala Phe Met Leu His Met Ile Asp Gln Tyr Asp Pro Leu Tyr 
    370                 375                 380                 


Ser Lys Arg Phe Ala Val Phe Leu Ser Glu Val Ser Glu Asn Lys Leu 
385                 390                 395                 400 


Lys Gln Leu Asn Leu Asn Asn Glu Trp Thr Pro Asp Lys Leu Arg Gln 
                405                 410                 415     


Lys Leu Gln Thr Asn Ala His Asn Arg Leu Glu Leu Pro Leu Ile Met 
            420                 425                 430         


Leu Ser Gly Leu Pro Asp Thr Val Phe Glu Ile Thr Glu Leu Gln Ser 
        435                 440                 445             


Leu Lys Leu Glu Ile Ile Lys Asn Val Met Ile Pro Ala Thr Ile Ala 
    450                 455                 460                 


Gln Leu Asp Asn Leu Gln Glu Leu Ser Leu His Gln Cys Ser Val Lys 
465                 470                 475                 480 


Ile His Ser Ala Ala Leu Ser Phe Leu Lys Glu Asn Leu Lys Val Leu 
                485                 490                 495     


Ser Val Lys Phe Asp Asp Met Arg Glu Leu Pro Pro Trp Met Tyr Gly 
            500                 505                 510         


Leu Arg Asn Leu Glu Glu Leu Tyr Leu Val Gly Ser Leu Ser His Asp 
        515                 520                 525             


Ile Ser Arg Asn Val Thr Leu Glu Ser Leu Arg Asp Leu Lys Ser Leu 
    530                 535                 540                 


Lys Ile Leu Ser Ile Lys Ser Asn Val Ser Lys Ile Pro Gln Ala Val 
545                 550                 555                 560 


Val Asp Val Ser Ser His Leu Gln Lys Met Cys Ile His Asn Asp Gly 
                565                 570                 575     


Thr Lys Leu Val Met Leu Asn Asn Leu Lys Lys Met Thr Asn Leu Thr 
            580                 585                 590         


Glu Leu Glu Leu Val His Cys Asp Leu Glu Arg Ile Pro His Ala Val 
        595                 600                 605             


Phe Ser Leu Leu Ser Leu Gln Glu Leu Asp Leu Lys Glu Asn Asn Leu 
    610                 615                 620                 


Lys Ser Ile Glu Glu Ile Val Ser Phe Gln His Leu Arg Lys Leu Thr 
625                 630                 635                 640 


Val Leu Lys Leu Trp His Asn Ser Ile Thr Tyr Ile Pro Glu His Ile 
                645                 650                 655     


Lys Lys Leu Thr Ser Leu Glu Arg Leu Ser Phe Ser His Asn Lys Ile 
            660                 665                 670         


Glu Val Leu Pro Ser His Leu Phe Leu Cys Asn Lys Ile Arg Tyr Leu 
        675                 680                 685             


Asp Leu Ser Tyr Asn Asp Ile Arg Phe Ile Pro Pro Glu Ile Gly Val 
    690                 695                 700                 


Leu Gln Ser Leu Gln Tyr Phe Ser Ile Thr Cys Asn Lys Val Glu Ser 
705                 710                 715                 720 


Leu Pro Asp Glu Leu Tyr Phe Cys Lys Lys Leu Lys Thr Leu Lys Ile 
                725                 730                 735     


Gly Lys Asn Ser Leu Ser Val Leu Ser Pro Lys Ile Gly Asn Leu Leu 
            740                 745                 750         


Phe Leu Ser Tyr Leu Asp Val Lys Gly Asn His Phe Glu Ile Leu Pro 
        755                 760                 765             


Pro Glu Leu Gly Asp Cys Arg Ala Leu Lys Arg Ala Gly Leu Val Val 
    770                 775                 780                 


Glu Asp Ala Leu Phe Glu Thr Leu Pro Ser Asp Val Arg Glu Gln Met 
785                 790                 795                 800 


Lys Thr Glu 
            


<210>  5316
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  5316

Met Glu Asn His Lys Ser Asn Asn Lys Glu Asn Ile Thr Ile Val Asp 
1               5                   10                  15      


Ile Ser Arg Lys Ile Asn Gln Leu Pro Glu Ala Glu Arg Asn Leu Leu 
            20                  25                  30          


Glu Asn Gly Ser Val Tyr Val Gly Leu Asn Ala Ala Leu Cys Gly Leu 
        35                  40                  45              


Ile Ala Asn Ser Leu Phe Arg Arg Ile Leu Asn Val Thr Lys Ala Arg 
    50                  55                  60                  


Ile Ala Ala Gly Leu Pro Met Ala Gly Ile Pro Phe Leu Thr Thr Asp 
65                  70                  75                  80  


Leu Thr Tyr Arg Cys Phe Val Ser Phe Pro Leu Asn Thr Gly Asp Leu 
                85                  90                  95      


Asp Cys Glu Thr Cys Thr Ile Thr Arg Ser Gly Leu Thr Gly Leu Val 
            100                 105                 110         


Ile Gly Gly Leu Tyr Pro Val Phe Leu Ala Ile Pro Val Asn Gly Gly 
        115                 120                 125             


Leu Ala Ala Arg Tyr Gln Ser Ala Leu Leu Pro His Lys Gly Asn Ile 
    130                 135                 140                 


Leu Ser Tyr Trp Ile Arg Thr Ser Lys Pro Val Phe Arg Lys Met Leu 
145                 150                 155                 160 


Phe Pro Ile Leu Leu Gln Thr Met Phe Ser Ala Tyr Leu Gly Ser Glu 
                165                 170                 175     


Gln Tyr Lys Leu Leu Ile Lys Ala Leu Gln Leu Ser Glu Pro Gly Lys 
            180                 185                 190         


Glu Ile His 
        195 


<210>  5317
<211>  315
<212>  PRT
<213>  Homo sapiens

<400>  5317

Met Gln Arg Arg Ser Arg Gly Ile Asn Thr Gly Leu Ile Leu Leu Leu 
1               5                   10                  15      


Ser Gln Ile Phe His Val Gly Ile Asn Asn Ile Pro Pro Val Thr Leu 
            20                  25                  30          


Ala Thr Leu Ala Leu Asn Ile Trp Phe Phe Leu Asn Pro Gln Lys Pro 
        35                  40                  45              


Leu Tyr Ser Ser Cys Leu Ser Val Glu Lys Cys Tyr Gln Gln Lys Asp 
    50                  55                  60                  


Trp Gln Arg Leu Leu Leu Ser Pro Leu His His Ala Asp Asp Trp His 
65                  70                  75                  80  


Leu Tyr Phe Asn Met Ala Ser Met Leu Trp Lys Gly Ile Asn Leu Glu 
                85                  90                  95      


Arg Arg Leu Gly Ser Arg Trp Phe Ala Tyr Val Ile Thr Ala Phe Ser 
            100                 105                 110         


Val Leu Thr Gly Val Val Tyr Leu Leu Leu Gln Phe Ala Val Ala Glu 
        115                 120                 125             


Phe Met Asp Glu Pro Asp Phe Lys Arg Ser Cys Ala Val Gly Phe Ser 
    130                 135                 140                 


Gly Val Leu Phe Ala Leu Lys Val Leu Asn Asn His Tyr Cys Pro Gly 
145                 150                 155                 160 


Gly Phe Val Asn Ile Leu Gly Phe Pro Val Pro Asn Arg Phe Ala Cys 
                165                 170                 175     


Trp Val Glu Leu Val Ala Ile His Leu Phe Ser Pro Gly Thr Ser Phe 
            180                 185                 190         


Ala Gly His Leu Ala Gly Ile Leu Val Gly Leu Met Tyr Thr Gln Gly 
        195                 200                 205             


Pro Leu Lys Lys Ile Met Glu Ala Cys Ala Gly Gly Phe Ser Ser Ser 
    210                 215                 220                 


Val Gly Tyr Pro Gly Arg Gln Tyr Tyr Phe Asn Ser Ser Gly Ser Ser 
225                 230                 235                 240 


Gly Tyr Gln Asp Tyr Tyr Pro His Gly Arg Pro Asp His Tyr Glu Glu 
                245                 250                 255     


Ala Pro Arg Asn Tyr Asp Thr Tyr Thr Ala Gly Leu Ser Glu Glu Glu 
            260                 265                 270         


Gln Leu Glu Arg Ala Leu Gln Ala Ser Leu Trp Asp Arg Gly Asn Thr 
        275                 280                 285             


Arg Asn Ser Pro Pro Pro Tyr Gly Phe His Leu Ser Pro Glu Glu Met 
    290                 295                 300                 


Arg Arg Gln Arg Leu His Arg Phe Asp Ser Gln 
305                 310                 315 


<210>  5318
<211>  1196
<212>  PRT
<213>  Homo sapiens

<400>  5318

Met Gly His Phe Glu Lys Gly Gln His Ala Leu Leu Asn Glu Gly Glu 
1               5                   10                  15      


Glu Asn Glu Met Glu Ile Phe Gly Tyr Arg Thr Gln Gly Cys Arg Lys 
            20                  25                  30          


Ser Leu Cys Leu Ala Gly Ser Ile Phe Ser Phe Gly Ile Leu Pro Leu 
        35                  40                  45              


Val Phe Tyr Trp Arg Pro Ala Trp His Val Trp Ala His Cys Val Pro 
    50                  55                  60                  


Cys Ser Leu Gln Glu Ala Asp Thr Val Leu Leu Arg Thr Thr Asp Glu 
65                  70                  75                  80  


Phe Gln Ile Tyr Ser Trp Lys Lys Val Ile Trp Ile Tyr Leu Ser Ala 
                85                  90                  95      


Leu Asn Ser Ala Phe Gly Leu Thr Pro Asp His Pro Leu Met Thr Asp 
            100                 105                 110         


Glu Glu Tyr Ile Ile Asn Arg Ala Ile Arg Lys Pro Asp Leu Lys Val 
        115                 120                 125             


Arg Cys Ile Lys Val Gln Lys Ile Arg Tyr Val Trp Asn Tyr Leu Glu 
    130                 135                 140                 


Gly Gln Phe Gln Lys Ile Gly Ser Leu Glu Asp Trp Leu Ser Ser Ala 
145                 150                 155                 160 


Lys Ile His Gln Lys Phe Gly Ser Gly Leu Thr Arg Glu Glu Gln Glu 
                165                 170                 175     


Ile Arg Arg Leu Ile Cys Gly Pro Asn Thr Ile Asp Val Glu Val Thr 
            180                 185                 190         


Pro Ile Trp Lys Leu Leu Ile Lys Glu Val Leu Asn Pro Phe Tyr Ile 
        195                 200                 205             


Phe Gln Leu Phe Ser Val Cys Leu Trp Phe Ser Glu Asp Tyr Lys Glu 
    210                 215                 220                 


Tyr Ala Phe Ala Ile Ile Ile Met Ser Ile Ile Ser Ile Ser Leu Thr 
225                 230                 235                 240 


Val Tyr Asp Leu Arg Glu Gln Ser Val Lys Leu His His Leu Val Glu 
                245                 250                 255     


Ser His Asn Ser Ile Thr Val Ser Val Cys Gly Arg Lys Ala Gly Val 
            260                 265                 270         


Gln Glu Leu Glu Ser Arg Val Leu Val Pro Gly Asp Leu Leu Ile Leu 
        275                 280                 285             


Thr Gly Asn Lys Val Leu Met Pro Cys Asp Ala Val Leu Ile Glu Gly 
    290                 295                 300                 


Ser Cys Val Val Asp Glu Gly Met Leu Thr Gly Glu Ser Ile Pro Val 
305                 310                 315                 320 


Thr Lys Thr Pro Leu Pro Lys Met Asp Ser Ser Val Pro Trp Lys Thr 
                325                 330                 335     


Gln Ser Glu Ala Asp Tyr Lys Arg His Val Leu Phe Cys Gly Thr Glu 
            340                 345                 350         


Val Ile Gln Ala Lys Ala Ala Cys Ser Gly Thr Val Arg Ala Val Val 
        355                 360                 365             


Leu Gln Thr Gly Phe Asn Thr Ala Lys Gly Asp Leu Val Arg Ser Ile 
    370                 375                 380                 


Leu Tyr Pro Lys Pro Val Asn Phe Gln Leu Tyr Arg Asp Ala Ile Arg 
385                 390                 395                 400 


Phe Leu Leu Cys Leu Val Gly Thr Ala Thr Ile Gly Met Ile Tyr Thr 
                405                 410                 415     


Leu Cys Val Tyr Val Leu Ser Gly Glu Pro Pro Glu Glu Val Val Arg 
            420                 425                 430         


Lys Ala Leu Asp Val Ile Thr Ile Ala Val Pro Pro Ala Leu Pro Ala 
        435                 440                 445             


Ala Leu Thr Thr Gly Ile Ile Tyr Ala Gln Arg Arg Leu Lys Lys Arg 
    450                 455                 460                 


Gly Ile Phe Cys Ile Ser Pro Gln Arg Ile Asn Val Cys Gly Gln Leu 
465                 470                 475                 480 


Asn Leu Val Cys Phe Asp Lys Thr Gly Thr Leu Thr Arg Asp Gly Leu 
                485                 490                 495     


Asp Leu Trp Gly Val Val Ser Cys Asp Arg Asn Gly Phe Gln Glu Val 
            500                 505                 510         


His Ser Phe Ala Ser Gly Gln Ala Leu Pro Trp Gly Pro Leu Cys Ala 
        515                 520                 525             


Ala Met Ala Ser Cys His Ser Leu Ile Leu Leu Asp Gly Thr Ile Gln 
    530                 535                 540                 


Gly Asp Pro Leu Asp Leu Lys Met Phe Glu Ala Thr Thr Trp Glu Met 
545                 550                 555                 560 


Ala Phe Ser Gly Asp Asp Phe His Ile Lys Gly Val Pro Ala His Ala 
                565                 570                 575     


Met Val Val Lys Pro Cys Arg Thr Ala Ser Gln Val Pro Val Glu Gly 
            580                 585                 590         


Ile Ala Ile Leu His Gln Phe Pro Phe Ser Ser Ala Leu Gln Arg Met 
        595                 600                 605             


Thr Val Ile Val Gln Glu Met Gly Gly Asp Arg Leu Ala Phe Met Lys 
    610                 615                 620                 


Gly Ala Pro Glu Arg Val Ala Ser Phe Cys Gln Pro Glu Thr Val Pro 
625                 630                 635                 640 


Thr Ser Phe Val Ser Glu Leu Gln Ile Tyr Thr Thr Gln Gly Phe Arg 
                645                 650                 655     


Val Ile Ala Leu Ala Tyr Lys Lys Leu Glu Asn Asp His His Ala Thr 
            660                 665                 670         


Thr Leu Thr Arg Glu Thr Val Glu Ser Asp Leu Ile Phe Leu Gly Leu 
        675                 680                 685             


Leu Ile Leu Glu Asn Arg Leu Lys Glu Glu Thr Lys Pro Val Leu Glu 
    690                 695                 700                 


Glu Leu Ile Ser Ala Arg Ile Arg Thr Val Met Ile Thr Gly Asp Asn 
705                 710                 715                 720 


Leu Gln Thr Ala Ile Thr Val Ala Arg Lys Ser Gly Met Val Ser Glu 
                725                 730                 735     


Ser Gln Lys Val Ile Leu Ile Glu Ala Asn Glu Thr Thr Gly Ser Ser 
            740                 745                 750         


Ser Ala Ser Ile Ser Trp Thr Leu Val Glu Glu Lys Lys His Ile Met 
        755                 760                 765             


Tyr Gly Asn Gln Asp Asn Tyr Ile Asn Ile Arg Asp Glu Val Ser Asp 
    770                 775                 780                 


Lys Gly Arg Glu Gly Ser Tyr His Phe Ala Leu Thr Gly Lys Ser Phe 
785                 790                 795                 800 


His Val Ile Ser Gln His Phe Ser Ser Leu Leu Pro Lys Ile Leu Ile 
                805                 810                 815     


Asn Gly Thr Ile Phe Ala Arg Met Ser Pro Gly Gln Lys Ser Ser Leu 
            820                 825                 830         


Val Glu Glu Phe Gln Lys Leu Asp Tyr Phe Val Gly Met Cys Gly Asp 
        835                 840                 845             


Gly Ala Asn Asp Cys Gly Ala Leu Lys Met Ala His Val Gly Ile Ser 
    850                 855                 860                 


Leu Ser Glu Gln Glu Ala Ser Val Ala Ser Pro Phe Thr Ser Lys Thr 
865                 870                 875                 880 


Pro Asn Ile Glu Cys Val Pro His Leu Ile Lys Glu Gly Arg Ala Ala 
                885                 890                 895     


Leu Val Thr Ser Phe Cys Met Phe Lys Tyr Met Ala Leu Tyr Ser Met 
            900                 905                 910         


Ile Gln Tyr Val Gly Val Leu Leu Leu Tyr Trp Glu Thr Asn Ser Leu 
        915                 920                 925             


Ser Asn Tyr Gln Phe Leu Phe Gln Asp Leu Ala Ile Thr Thr Leu Ile 
    930                 935                 940                 


Gly Val Thr Met Asn Leu Asn Gly Ala Tyr Pro Lys Leu Val Pro Phe 
945                 950                 955                 960 


Arg Pro Ala Gly Arg Leu Ile Ser Pro Pro Leu Leu Leu Ser Val Ile 
                965                 970                 975     


Phe Asn Ile Leu Leu Ser Leu Ala Met His Ile Ala Gly Phe Ile Leu 
            980                 985                 990         


Val Gln Arg Gln Pro Trp Tyr Ser  Val Glu Ile His Ser  Ala Cys Thr 
        995                 1000                 1005             


Val Gln  Asn Glu Ser Ile Ser  Glu Leu Thr Met Ser  Pro Thr Ala 
    1010                 1015                 1020             


Pro Glu  Lys Met Glu Ser Asn  Ser Thr Phe Thr Ser  Phe Glu Asn 
    1025                 1030                 1035             


Thr Thr  Val Trp Phe Leu Gly  Thr Ile Asn Cys Ile  Thr Val Ala 
    1040                 1045                 1050             


Leu Val  Phe Ser Lys Gly Lys  Pro Phe Arg Gln Pro  Thr Tyr Thr 
    1055                 1060                 1065             


Asn Tyr  Ile Phe Val Leu Val  Leu Ile Ile Gln Leu  Gly Val Cys 
    1070                 1075                 1080             


Leu Phe  Ile Leu Phe Ala Asp  Ile Pro Glu Leu Tyr  Arg Arg Leu 
    1085                 1090                 1095             


Asp Leu  Leu Cys Thr Pro Val  Leu Trp Arg Ala Ser  Ile Val Ile 
    1100                 1105                 1110             


Met Leu  Ser Leu Asn Phe Ile  Val Ser Leu Val Ala  Glu Glu Ala 
    1115                 1120                 1125             


Val Ile  Glu Asn Arg Ala Leu  Trp Met Met Ile Lys  Arg Cys Phe 
    1130                 1135                 1140             


Gly Tyr  Gln Ser Lys Ser Gln  Tyr Arg Ile Trp Gln  Arg Asp Leu 
    1145                 1150                 1155             


Ala Asn  Asp Pro Ser Trp Pro  Pro Leu Asn Gln Thr  Ser His Ser 
    1160                 1165                 1170             


Asp Met  Pro Glu Cys Gly Arg  Gly Val Ser Tyr Ser  Asn Pro Val 
    1175                 1180                 1185             


Phe Glu  Ser Asn Glu Glu Gln  Leu 
    1190                 1195     


<210>  5319
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  5319

Met Lys Asp Cys Glu Tyr Gln Gln Ile Ser Pro Gly Ala Ala Pro Leu 
1               5                   10                  15      


Pro Ala Ser Pro Gly Ala Arg Arg Pro Gly Pro Ala Ala Ser Pro Thr 
            20                  25                  30          


Pro Gly Pro Gly Pro Ala Pro Pro Ala Ala Pro Ala Pro Pro Arg Trp 
        35                  40                  45              


Ser Ser Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Leu Gly Arg 
    50                  55                  60                  


Arg Pro Arg Arg Lys Trp Glu Val Phe Pro Gly Arg Asn Arg Phe Tyr 
65                  70                  75                  80  


Cys Gly Gly Arg Leu Met Leu Ala Gly His Gly Gly Val Phe Ala Leu 
                85                  90                  95      


Thr Leu Leu Leu Ile Leu Thr Thr Thr Gly Leu Phe Phe Val Phe Asp 
            100                 105                 110         


Cys Pro Tyr Leu Ala Arg Lys Leu Thr Leu Ala Ile Pro Ile Ile Ala 
        115                 120                 125             


Ala Ile Leu Phe Phe Phe Val Met Ser Cys Leu Leu Gln Thr Ser Phe 
    130                 135                 140                 


Thr Asp Pro Gly Ile Leu Pro Arg Ala Thr Val Cys Glu Ala Ala Ala 
145                 150                 155                 160 


Leu Glu Lys Gln Ile Asp Asn Thr Gly Ser Ser Thr Tyr Arg Pro Pro 
                165                 170                 175     


Pro Arg Thr Arg Glu Val Leu Ile Asn Gly Gln Met Val Lys Leu Lys 
            180                 185                 190         


Tyr Cys Phe Thr Cys Lys Met Phe Arg Pro Pro Arg Thr Ser His Cys 
        195                 200                 205             


Ser Val Cys Asp Asn Cys Val Glu Arg Phe Asp His His Cys Pro Trp 
    210                 215                 220                 


Val Gly Asn Cys Val Gly Arg Arg Asn Tyr Arg Phe Phe Tyr Ala Phe 
225                 230                 235                 240 


Ile Leu Ser Leu Ser Phe Leu Thr Ala Phe Ile Phe Ala Cys Val Val 
                245                 250                 255     


Thr His Leu Thr Leu Arg Ala Gln Gly Ser Asn Phe Leu Ser Thr Leu 
            260                 265                 270         


Lys Glu Thr Pro Ala Ser Val Leu Glu Leu Val Ile Cys Phe Phe Ser 
        275                 280                 285             


Ile Trp Ser Ile Leu Gly Leu Ser Gly Phe His Thr Tyr Leu Val Ala 
    290                 295                 300                 


Ser Asn Leu Thr Thr Asn Glu Asp Ile Lys Gly Ser Trp Ser Ser Lys 
305                 310                 315                 320 


Arg Gly Gly Glu Ala Ser Val Asn Pro Tyr Ser His Lys Ser Ile Ile 
                325                 330                 335     


Thr Asn Cys Cys Ala Val Leu Cys Gly Pro Leu Pro Pro Ser Leu Ile 
            340                 345                 350         


Asp Arg Arg Gly Phe Val Gln Ser Asp Thr Val Leu Pro Ser Pro Ile 
        355                 360                 365             


Arg Ser Asp Glu Pro Ala Cys Arg Ala Lys Pro Asp Ala Ser Met Val 
    370                 375                 380                 


Gly Gly His Pro 
385             


<210>  5320
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  5320

Met Ala Trp Pro Asn Val Phe Gln Arg Gly Ser Leu Leu Ser Gln Phe 
1               5                   10                  15      


Ser His His His Val Val Val Phe Leu Leu Thr Phe Phe Ser Tyr Ser 
            20                  25                  30          


Leu Leu His Ala Ser Arg Lys Thr Phe Ser Asn Val Lys Val Ser Ile 
        35                  40                  45              


Ser Glu Gln Trp Thr Pro Ser Ala Phe Asn Thr Ser Val Glu Leu Pro 
    50                  55                  60                  


Val Glu Ile Trp Ser Ser Asn His Leu Phe Pro Ser Ala Glu Lys Ala 
65                  70                  75                  80  


Thr Leu Phe Leu Gly Thr Leu Asp Thr Ile Phe Leu Phe Ser Tyr Ala 
                85                  90                  95      


Val Gly Leu Phe Ile Ser Gly Ile Val Gly Asp Arg Leu Asn Leu Arg 
            100                 105                 110         


Trp Val Leu Ser Phe Gly Met Cys Ser Ser Ala Leu Val Val Phe Val 
        115                 120                 125             


Phe Gly Ala Leu Thr Glu Trp Leu Arg Phe Tyr Asn Lys Trp Leu Tyr 
    130                 135                 140                 


Cys Cys Leu Trp Ile Val Asn Gly Leu Leu Gln Ser Thr Gly Trp Pro 
145                 150                 155                 160 


Cys Val Val Ala Val Met Gly Asn Trp Phe Gly Lys Ala Gly Arg Gly 
                165                 170                 175     


Val Val Phe Gly Leu Trp Ser Ala Cys Ala Ser Val Gly Asn Ile Leu 
            180                 185                 190         


Gly Ala Cys Leu Ala Ser Ser Val Leu Gln Tyr Gly Tyr Glu Tyr Ala 
        195                 200                 205             


Phe Leu Val Thr Ala Ser Val Gln Phe Ala Gly Gly Ile Val Ile Phe 
    210                 215                 220                 


Phe Gly Leu Leu Val Ser Pro Glu Glu Ile Gly Leu Ser Gly Ile Glu 
225                 230                 235                 240 


Ala Glu Glu Asn Phe Glu Glu Asp Ser His Arg Pro Leu Ile Asn Gly 
                245                 250                 255     


Gly Glu Asn Glu Asp Glu Tyr Glu Pro Asn Tyr Ser Ile Gln Asp Asp 
            260                 265                 270         


Ser Ser Val Ala Gln Val Lys Ala Ile Ser Phe Tyr Gln Ala Cys Cys 
        275                 280                 285             


Leu Pro Gly Val Ile Pro Tyr Ser Leu Ala Tyr Ala Cys Leu Lys Leu 
    290                 295                 300                 


Val Asn Tyr Ser Phe Phe Phe Trp Leu Pro Phe Tyr Leu Ser Asn Asn 
305                 310                 315                 320 


Phe Gly Trp Lys Glu Ala Glu Ala Asp Lys Leu Ser Ile Trp Tyr Asp 
                325                 330                 335     


Val Gly Gly Ile Ile Val Phe Ser Val Ser Asp Pro Gly Gln Ala Arg 
            340                 345                 350         


Met Asp Val Gly Phe Leu Leu Phe His Ser His Asp Lys Leu Tyr Asn 
        355                 360                 365             


Cys Val Tyr Leu Ala Ile Asn Ser Glu Gly Asn Ile Leu Ser Arg Ala 
    370                 375                 380                 


Lys Glu Thr Gly Ser His Ile Glu Gly Val Thr Gly Ala Arg Glu Thr 
385                 390                 395                 400 


Glu Arg Thr Met Ser Ala Thr Ser Gly Pro Leu Gly Leu Arg Val Cys 
                405                 410                 415     


Pro Asn Leu Gly Leu Ser Arg Ser Ser Ser Leu Ile Leu Asp Cys Gln 
            420                 425                 430         


Ala Ser Leu Asn Thr Ala Ser His Leu Arg Cys 
        435                 440             


<210>  5321
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  5321

Met Pro Val Lys Lys Lys Arg Lys Ser Pro Gly Val Ala Ala Ala Val 
1               5                   10                  15      


Ala Glu Asp Gly Gly Leu Lys Lys Cys Lys Ile Ser Ser Tyr Cys Arg 
            20                  25                  30          


Ser Gln Pro Pro Ala Arg Leu Ile Ser Gly Glu Glu His Phe Ser Ser 
        35                  40                  45              


Lys Lys Cys Leu Ala Trp Phe Tyr Glu Tyr Ala Gly Pro Asp Glu Val 
    50                  55                  60                  


Val Gly Pro Glu Gly Met Glu Lys Phe Cys Glu Asp Ile Gly Val Glu 
65                  70                  75                  80  


Pro Glu Asn Ile Ile Met Leu Val Leu Ala Trp Lys Leu Glu Ala Glu 
                85                  90                  95      


Ser Met Gly Phe Phe Thr Lys Glu Glu Trp Leu Lys Gly Met Thr Ser 
            100                 105                 110         


Leu Gln Cys Asp Cys Thr Glu Lys Leu Gln Asn Lys Phe Asp Phe Leu 
        115                 120                 125             


Arg Ser Gln Leu Asn Asp Ile Ser Ser Phe Lys Asn Ile Tyr Arg Tyr 
    130                 135                 140                 


Ala Phe Asp Phe Ala Arg Asp Lys Asp Gln Arg Ser Leu Asp Ile Asp 
145                 150                 155                 160 


Thr Ala Lys Ser Met Leu Ala Leu Leu Leu Gly Arg Thr Trp Pro Leu 
                165                 170                 175     


Phe Ser Val Phe Tyr Gln Tyr Leu Glu Gln Ser Lys Tyr Arg Val Met 
            180                 185                 190         


Asn Lys Asp Gln Trp Tyr Asn Val Leu Glu Phe Ser Arg Thr Val His 
        195                 200                 205             


Ala Asp Leu Ser Asn Tyr Asp Glu Asp Gly Ala Trp Pro Val Leu Leu 
    210                 215                 220                 


Asp Glu Phe Val Glu Trp Gln Lys Val Arg Gln Thr Ser 
225                 230                 235         


<210>  5322
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  5322

Met Thr Asp Gln Thr Tyr Cys Asp Arg Leu Val Gln Asp Thr Pro Phe 
1               5                   10                  15      


Leu Thr Gly His Gly Arg Leu Ser Glu Gln Gln Val Asp Arg Ile Ile 
            20                  25                  30          


Leu Gln Leu Asn Arg Tyr Tyr Pro Gln Ile Leu Thr Asn Lys Glu Ala 
        35                  40                  45              


Glu Lys Phe Arg Asn Pro Lys Ala Ser Leu Arg Val Arg Leu Cys Asp 
    50                  55                  60                  


Leu Leu Ser His Leu Gln Arg Ser Gly Glu Arg Asp Cys Gln Glu Phe 
65                  70                  75                  80  


Tyr Arg Ala Leu Tyr Ile His Ala Gln Pro Leu His Ser Arg Leu Pro 
                85                  90                  95      


Ser Arg His Ala Leu Gln Asn Ser Asp Cys Thr Glu Leu Asp Ser Gly 
            100                 105                 110         


Ser Gln Ser Gly Glu Leu Ser Asn Arg Gly Pro Met Ser Phe Leu Ala 
        115                 120                 125             


Gly Leu Gly Leu Ala Val Gly Leu Ala Leu Leu Leu Tyr Cys Tyr Pro 
    130                 135                 140                 


Pro Asp Pro Lys Gly Leu Pro Gly Thr Arg Arg Val Leu Gly Phe Ser 
145                 150                 155                 160 


Pro Val Ile Ile Asp Arg His Val Ser Arg Tyr Leu Leu Ala Phe Leu 
                165                 170                 175     


Ala Asp Asp Leu Gly Gly Leu 
            180             


<210>  5323
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  5323

Met Gln Pro Pro Gly Pro Pro Pro Ala Tyr Ala Pro Thr Asn Gly Asp 
1               5                   10                  15      


Phe Thr Phe Val Ser Ser Ala Asp Ala Glu Asp Leu Ser Gly Ser Ile 
            20                  25                  30          


Ala Ser Pro Asp Val Lys Leu Asn Leu Gly Gly Asp Phe Ile Lys Glu 
        35                  40                  45              


Ser Thr Ala Thr Thr Phe Leu Arg Gln Arg Gly Tyr Gly Trp Leu Leu 
    50                  55                  60                  


Glu Val Glu Asp Asp Asp Pro Glu Asp Asn Lys Pro Leu Leu Glu Glu 
65                  70                  75                  80  


Leu Asp Ile Asp Leu Lys Asp Ile Tyr Tyr Lys Ile Arg Cys Val Leu 
                85                  90                  95      


Met Pro Met Pro Ser Leu Gly Phe Asn Arg Gln Val Val Arg Asp Asn 
            100                 105                 110         


Pro Asp Phe Trp Gly Pro Leu Ala Val Val Leu Phe Phe Ser Met Ile 
        115                 120                 125             


Ser Leu Tyr Gly Gln Phe Arg Val Val Ser Trp Ile Ile Thr Ile Trp 
    130                 135                 140                 


Ile Phe Gly Ser Leu Thr Ile Phe Leu Leu Ala Arg Val Leu Gly Gly 
145                 150                 155                 160 


Glu Val Ala Tyr Gly Gln Val Leu Gly Val Ile Gly Tyr Ser Leu Leu 
                165                 170                 175     


Pro Leu Ile Val Ile Ala Pro Val Leu Leu Val Val Gly Ser Phe Glu 
            180                 185                 190         


Val Val Ser Thr Leu Ile Lys Leu Phe Gly Val Phe Trp Ala Ala Tyr 
        195                 200                 205             


Ser Ala Ala Ser Leu Leu Val Gly Glu Glu Phe Lys Thr Lys Lys Pro 
    210                 215                 220                 


Leu Leu Ile Tyr Pro Ile Phe Leu Leu Tyr Ile Tyr Phe Leu Ser Leu 
225                 230                 235                 240 


Tyr Thr Gly Val 
                


<210>  5324
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  5324

Met Ala Thr Gly Gly Gln Gln Lys Glu Asn Thr Leu Leu His Leu Phe 
1               5                   10                  15      


Ala Gly Gly Cys Gly Gly Thr Val Gly Ala Ile Phe Thr Cys Pro Leu 
            20                  25                  30          


Glu Val Ile Lys Thr Arg Leu Gln Ser Ser Arg Leu Ala Leu Arg Thr 
        35                  40                  45              


Val Tyr Tyr Pro Gln Val His Leu Gly Thr Ile Ser Gly Ala Gly Met 
    50                  55                  60                  


Val Arg Pro Thr Ser Val Thr Pro Gly Leu Phe Gln Val Leu Lys Ser 
65                  70                  75                  80  


Ile Leu Glu Lys Glu Gly Pro Lys Ser Leu Phe Arg Gly Leu Gly Pro 
                85                  90                  95      


Asn Leu Val Gly Val Ala Pro Ser Arg Ala Val Tyr Phe Ala Cys Tyr 
            100                 105                 110         


Ser Lys Ala Lys Glu Gln Phe Asn Gly Ile Phe Val Pro Asn Ser Asn 
        115                 120                 125             


Ile Val His Ile Phe Ser Ala Gly Ser Ala Ala Phe Ile Thr Asn Ser 
    130                 135                 140                 


Leu Met Asn Pro Ile Trp Met Val Lys Thr Arg Met Gln Leu Glu Gln 
145                 150                 155                 160 


Lys Val Arg Gly Ser Lys Gln Met Asn Thr Leu Gln Cys Ala Arg Tyr 
                165                 170                 175     


Val Tyr Gln Thr Glu Gly Ile Arg Gly Phe Tyr Arg Gly Leu Thr Ala 
            180                 185                 190         


Ser Tyr Ala Gly Ile Ser Glu Thr Ile Ile Cys Phe Ala Ile Tyr Glu 
        195                 200                 205             


Ser Leu Lys Lys Tyr Leu Lys Glu Ala Pro Leu Ala Ser Ser Ala Asn 
    210                 215                 220                 


Gly Thr Glu Lys Asn Ser Thr Ser Phe Phe Gly Leu Met Ala Ala Ala 
225                 230                 235                 240 


Ala Leu Ser Lys Gly Cys Ala Ser Cys Ile Ala Tyr Pro His Glu Val 
                245                 250                 255     


Ile Arg Thr Arg Leu Arg Glu Glu Gly Thr Lys Tyr Lys Ser Phe Val 
            260                 265                 270         


Gln Thr Ala Arg Leu Val Phe Arg Glu Glu Gly Tyr Leu Ala Phe Tyr 
        275                 280                 285             


Arg Gly Leu Phe Ala Gln Leu Ile Arg Gln Ile Pro Asn Thr Ala Ile 
    290                 295                 300                 


Val Leu Ser Thr Tyr Glu Leu Ile Val Tyr Leu Leu Glu Asp Arg Thr 
305                 310                 315                 320 


Gln 
    


<210>  5325
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  5325

Met Ala Ala Met Arg Trp Arg Trp Trp Gln Arg Leu Leu Pro Trp Arg 
1               5                   10                  15      


Leu Leu Gln Ala Arg Gly Phe Pro Gln Asn Ser Ala Pro Ser Leu Gly 
            20                  25                  30          


Leu Gly Ala Arg Thr Tyr Ser Gln Gly Asp Cys Ser Tyr Ser Arg Thr 
        35                  40                  45              


Ala Leu Tyr Asp Leu Leu Gly Val Pro Ser Thr Ala Thr Gln Ala Gln 
    50                  55                  60                  


Ile Lys Ala Ala Tyr Tyr Arg Gln Cys Phe Leu Tyr His Pro Asp Arg 
65                  70                  75                  80  


Asn Ser Gly Ser Ala Glu Ala Ala Glu Arg Phe Thr Arg Ile Ser Gln 
                85                  90                  95      


Ala Tyr Val Val Leu Gly Ser Ala Thr Leu Arg Arg Lys Tyr Asp Arg 
            100                 105                 110         


Gly Leu Leu Ser Asp Glu Asp Leu Arg Gly Pro Gly Val Arg Pro Ser 
        115                 120                 125             


Arg Thr Pro Ala Pro Asp Pro Gly Ser Pro Arg Thr Pro Pro Pro Thr 
    130                 135                 140                 


Ser Arg Thr His Asp Gly Ser Arg Ala Ser Pro Gly Ala Asn Arg Thr 
145                 150                 155                 160 


Met Phe Asn Phe Asp Ala Phe Tyr Gln Ala His Tyr Gly Glu Gln Leu 
                165                 170                 175     


Glu Arg Glu Arg Arg Leu Arg Ala Arg Arg Glu Ala Leu Arg Lys Arg 
            180                 185                 190         


Gln Glu Tyr Arg Ser Met Lys Gly Leu Arg Trp Glu Asp Thr Arg Asp 
        195                 200                 205             


Thr Ala Ala Ile Phe Leu Ile Phe Ser Ile Phe Ile Ile Ile Gly Phe 
    210                 215                 220                 


Tyr Ile 
225     


<210>  5326
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  5326

Met Val Pro Gly Ala Ala Gly Trp Cys Cys Leu Val Leu Trp Leu Pro 
1               5                   10                  15      


Ala Cys Val Ala Ala His Gly Phe Arg Ile His Asp Tyr Leu Tyr Phe 
            20                  25                  30          


Gln Val Leu Ser Pro Gly Asp Ile Arg Tyr Ile Phe Thr Ala Thr Pro 
        35                  40                  45              


Ala Lys Asp Phe Gly Gly Ile Phe His Thr Arg Tyr Glu Gln Ile His 
    50                  55                  60                  


Leu Val Pro Ala Glu Pro Pro Glu Ala Cys Gly Glu Leu Ser Asn Gly 
65                  70                  75                  80  


Phe Phe Ile Gln Asp Gln Ile Ala Leu Val Glu Arg Gly Gly Cys Ser 
                85                  90                  95      


Phe Leu Ser Lys Thr Arg Val Val Gln Glu His Gly Gly Arg Ala Val 
            100                 105                 110         


Ile Ile Ser Asp Asn Ala Val Asp Asn Asp Ser Phe Tyr Val Glu Met 
        115                 120                 125             


Ile Gln Asp Ser Thr Gln Arg Thr Ala Asp Ile Pro Ala Leu Phe Leu 
    130                 135                 140                 


Leu Gly Arg Asp Gly Tyr Met Ile Arg Arg Ser Leu Glu Gln His Gly 
145                 150                 155                 160 


Leu Pro Trp Ala Ile Ile Ser Ile Pro Val Asn Val Thr Ser Ile Pro 
                165                 170                 175     


Thr Phe Glu Leu Leu Gln Pro Pro Trp Thr Phe Trp 
            180                 185             


<210>  5327
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  5327

Met Thr Glu Gln Glu Thr Leu Ala Leu Leu Glu Val Lys Arg Ser Asp 
1               5                   10                  15      


Ser Pro Glu Lys Ser Ser Pro Gln Ala Leu Val Pro Asn Gly Arg Gln 
            20                  25                  30          


Pro Glu Gly Glu Gly Gly Ala Glu Ser Pro Gly Ala Glu Ser Leu Arg 
        35                  40                  45              


Val Gly Ser Ser Ala Gly Ser Pro Thr Ala Ile Glu Gly Ala Glu Asp 
    50                  55                  60                  


Gly Leu Asp Ser Thr Val Ser Glu Ala Ala Thr Leu Pro Trp Gly Thr 
65                  70                  75                  80  


Gly Pro Gln Pro Ser Ala Pro Phe Pro Asp Pro Pro Gly Trp Arg Asp 
                85                  90                  95      


Ile Glu Pro Glu Pro Pro Glu Ser Glu Pro Leu Thr Lys Leu Glu Glu 
            100                 105                 110         


Leu Pro Glu Asp Asp Ala Asn Leu Leu Pro Glu Lys Ala Ala Arg Ala 
        115                 120                 125             


Phe Val Pro Ile Asp Leu Gln Cys Ile Glu Arg Gln Pro Gln Glu Asp 
    130                 135                 140                 


Leu Ile Val Arg Cys Glu Ala Gly Glu Gly Glu Cys Arg Thr Phe Met 
145                 150                 155                 160 


Pro Pro Arg Val Thr His Pro Asp Pro Thr Glu Arg Lys Trp Ala Glu 
                165                 170                 175     


Ala Val Val Arg Pro Pro Gly Cys Ser Cys Gly Gly Cys Gly Ser Cys 
            180                 185                 190         


Gly Asp Arg Glu Trp Leu Arg Ala Val Ala Ser Val Gly Ala Ala Leu 
        195                 200                 205             


Ile Leu Phe Pro Cys Leu Leu Tyr Gly Ala Tyr Ala Phe Leu Pro Phe 
    210                 215                 220                 


Asp Val Pro Arg Leu Pro Thr Met Ser Ser Arg Leu Ile Tyr Thr Leu 
225                 230                 235                 240 


Arg Cys Gly Val Phe Ala Thr Phe Pro Ile Val Leu Gly Ile Leu Val 
                245                 250                 255     


Tyr Gly Leu Ser Leu Leu Cys Phe Ser Ala Leu Arg Pro Phe Gly Glu 
            260                 265                 270         


Pro Arg Arg Glu Val Glu Ile His Arg Arg Tyr Val Ala Gln Ser Val 
        275                 280                 285             


Gln Leu Phe Ile Leu Tyr Phe Phe Asn Leu Ala Val Leu Ser Thr Tyr 
    290                 295                 300                 


Leu Pro Gln Asp Thr Leu Lys Leu Leu Pro Leu Leu Thr Gly Leu Phe 
305                 310                 315                 320 


Ala Val Ser Arg Leu Ile Tyr Trp Leu Thr Phe Ala Val Gly Arg Ser 
                325                 330                 335     


Phe Arg Gly Phe Gly Tyr Gly Leu Thr Phe Leu Pro Leu Leu Ser Met 
            340                 345                 350         


Leu Met Trp Asn Leu Tyr Tyr Met Phe Val Val Glu Pro Glu Arg Met 
        355                 360                 365             


Leu Thr Ala Thr Glu Ser Arg Leu Asp Tyr Pro Asp His Ala Arg Ser 
    370                 375                 380                 


Ala Ser Asp Tyr Arg Pro Arg Pro Trp Gly 
385                 390                 


<210>  5328
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  5328

Met Ser Gln Pro Arg Thr Pro Glu Gln Ala Leu Asp Thr Pro Gly Asp 
1               5                   10                  15      


Cys Pro Pro Gly Arg Arg Asp Glu Asp Ala Gly Glu Gly Ile Gln Cys 
            20                  25                  30          


Ser Gln Arg Met Leu Ser Phe Ser Asp Ala Leu Leu Ser Ile Ile Ala 
        35                  40                  45              


Thr Val Met Ile Leu Pro Val Thr His Thr Glu Ile Ser Pro Glu Gln 
    50                  55                  60                  


Gln Phe Asp Arg Ser Val Gln Arg Leu Leu Ala Thr Arg Ile Ala Val 
65                  70                  75                  80  


Tyr Leu Met Thr Phe Leu Ile Val Thr Val Ala Trp Ala Ala His Thr 
                85                  90                  95      


Arg Leu Phe Gln Val Val Gly Lys Thr Asp Asp Thr Leu Ala Leu Leu 
            100                 105                 110         


Asn Leu Ala Cys Met Met Thr Ile Thr Phe Leu Pro Tyr Thr Phe Ser 
        115                 120                 125             


Leu Met Val Thr Phe Pro Asp Val Pro Leu Gly Ile Phe Leu Phe Cys 
    130                 135                 140                 


Val Cys Val Ile Ala Ile Gly Val Val Gln Ala Leu Ile Val Gly Tyr 
145                 150                 155                 160 


Ala Phe His Phe Pro His Leu Leu Ser Pro Gln Ile Gln Arg Ser Ala 
                165                 170                 175     


His Arg Ala Leu Tyr Arg Arg His Val Leu Gly Ile Val Leu Gln Gly 
            180                 185                 190         


Pro Ala Leu Cys Phe Ala Ala Ala Ile Phe Ser Leu Phe Phe Val Pro 
        195                 200                 205             


Leu Ser Tyr Leu Leu Met Val Thr Val Ile Leu Leu Pro Tyr Val Ser 
    210                 215                 220                 


Lys Val Thr Gly Trp Cys Arg Asp Arg Leu Leu Gly His Arg Glu Pro 
225                 230                 235                 240 


Ser Ala His Pro Val Glu Val Phe Ser Phe Asp Leu His Glu Pro Leu 
                245                 250                 255     


Ser Lys Glu Arg Val Glu Ala Phe Ser Asp Gly Val Tyr Ala Ile Val 
            260                 265                 270         


Ala Thr Leu Leu Ile Leu Asp Ile Cys Glu Asp Asn Val Pro Asp Pro 
        275                 280                 285             


Lys Asp Val Lys Glu Arg Phe Ser Gly Ser Leu Val Ala Ala Leu Ser 
    290                 295                 300                 


Ala Thr Gly Pro Arg Phe Leu Ala Tyr Phe Gly Ser Phe Ala Thr Val 
305                 310                 315                 320 


Gly Leu Leu Trp Phe Ala His His Ser Leu Phe Leu His Val Arg Lys 
                325                 330                 335     


Ala Thr Arg Ala Met Gly Leu Leu Asn Thr Leu Ser Leu Ala Phe Val 
            340                 345                 350         


Gly Gly Leu Pro Leu Ala Tyr Gln Gln Thr Ser Ala Phe Ala Arg Gln 
        355                 360                 365             


Pro Arg Asp Glu Leu Glu Arg Val Arg Val Ser Cys Thr Ile Ile Phe 
    370                 375                 380                 


Leu Ala Ser Ile Phe Gln Leu Ala Met Trp Thr Thr Ala Leu Leu His 
385                 390                 395                 400 


Gln Ala Glu Thr Leu Gln Pro Ser Val Trp Phe Gly Gly Arg Glu His 
                405                 410                 415     


Val Leu Met Phe Ala Lys Leu Ala Leu Tyr Pro Cys Ala Ser Leu Leu 
            420                 425                 430         


Ala Phe Ala Ser Thr Cys Leu Leu Ser Arg Phe Ser Val Gly Ile Phe 
        435                 440                 445             


His Leu Met Gln Ile Ala Val Pro Cys Ala Phe Leu Leu Leu Arg Leu 
    450                 455                 460                 


Leu Val Gly Leu Ala Leu Ala Thr Leu Arg Val Leu Arg Gly Leu Ala 
465                 470                 475                 480 


Arg Pro Glu His Pro Pro Pro Ala Pro Thr Gly Gln Asp Asp Pro Gln 
                485                 490                 495     


Ser Gln Leu Leu Pro Ala Pro Cys 
            500                 


<210>  5329
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  5329

Met Ala Ser Pro Gly Ala Gly Arg Ala Pro Pro Glu Leu Pro Glu Arg 
1               5                   10                  15      


Asn Cys Gly Tyr Arg Glu Val Glu Tyr Trp Asp Gln Arg Tyr Gln Gly 
            20                  25                  30          


Ala Ala Asp Ser Ala Pro Tyr Asp Trp Phe Gly Asp Phe Ser Ser Phe 
        35                  40                  45              


Arg Ala Leu Leu Glu Pro Glu Leu Arg Pro Glu Asp Arg Ile Leu Val 
    50                  55                  60                  


Leu Gly Cys Gly Asn Ser Ala Leu Ser Tyr Glu Leu Phe Leu Gly Gly 
65                  70                  75                  80  


Phe Pro Asn Val Thr Ser Val Asp Tyr Ser Ser Val Val Val Ala Ala 
                85                  90                  95      


Met Gln Ala Arg His Ala His Val Pro Gln Leu Arg Trp Glu Thr Met 
            100                 105                 110         


Asp Val Arg Lys Leu Asp Phe Pro Ser Ala Ser Phe Asp Val Val Leu 
        115                 120                 125             


Glu Lys Gly Thr Leu Asp Ala Leu Leu Ala Gly Glu Arg Asp Pro Trp 
    130                 135                 140                 


Thr Val Ser Ser Glu Gly Val His Thr Val Asp Gln Val Leu Ser Glu 
145                 150                 155                 160 


Val Ser Arg Val Leu Val Pro Gly Gly Arg Phe Ile Ser Met Thr Ser 
                165                 170                 175     


Ala Ala Pro His Phe Arg Thr Arg His Tyr Ala Gln Ala Tyr Tyr Gly 
            180                 185                 190         


Trp Ser Leu Arg His Ala Thr Tyr Gly Ser Gly Phe His Phe His Leu 
        195                 200                 205             


Tyr Leu Met His Lys Gly Gly Lys Leu Ser Val Ala Gln Leu Ala Leu 
    210                 215                 220                 


Gly Ala Gln Ile Leu Ser Pro Pro Arg Pro Pro Thr Ser Pro Cys Phe 
225                 230                 235                 240 


Leu Gln Asp Ser Asp His Glu Asp Phe Leu Ser Ala Ile Gln Leu 
                245                 250                 255 


<210>  5330
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  5330

Met Gly Ala Gly Thr Ala Gly Glu Leu Pro Ala Asn Ser Val Ser Gly 
1               5                   10                  15      


Phe Phe Lys Arg Met Val Lys Ser Glu Ala Ser Asn Ala Ala Thr Ala 
            20                  25                  30          


Tyr Phe Arg Pro Ala Arg Pro Leu Pro Ser Leu Val Thr Val Leu Gly 
        35                  40                  45              


Leu Gly Tyr Phe Ala Trp Val Val Phe Trp Pro Gln Ser Ile Pro Tyr 
    50                  55                  60                  


Gln Asn Leu Gly Pro Leu Gly Pro Phe Thr Gln Tyr Leu Val Asp His 
65                  70                  75                  80  


His His Thr Leu Leu Cys Asn Gly Tyr Trp Leu Ala Trp Leu Ile His 
                85                  90                  95      


Val Gly Glu Ser Leu Tyr Ala Ile Val Leu Cys Lys His Lys Gly Ile 
            100                 105                 110         


Thr Ser Gly Arg Ala Gln Leu Leu Trp Phe Leu Gln Thr Phe Phe Phe 
        115                 120                 125             


Gly Ile Ala Ser Leu Thr Ile Leu Ile Ala Tyr Lys Arg Lys Arg Gln 
    130                 135                 140                 


Lys Gln Thr 
145         


<210>  5331
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  5331

Met Ser Phe Leu Gln Asp Pro Ser Phe Phe Thr Met Gly Met Trp Ser 
1               5                   10                  15      


Ile Gly Ala Gly Ala Leu Gly Ala Ala Ala Leu Ala Leu Leu Leu Ala 
            20                  25                  30          


Asn Thr Asp Val Phe Leu Ser Lys Pro Gln Lys Ala Ala Leu Glu Tyr 
        35                  40                  45              


Leu Glu Asp Ile Asp Leu Lys Thr Leu Glu Lys Glu Pro Arg Thr Phe 
    50                  55                  60                  


Lys Ala Lys Glu Leu Trp Glu Lys Asn Gly Ala Val Ile Met Ala Val 
65                  70                  75                  80  


Arg Arg Pro Gly Cys Phe Leu Cys Arg Glu Glu Ala Ala Asp Leu Ser 
                85                  90                  95      


Ser Leu Lys Ser Met Leu Asp Gln Leu Gly Val Pro Leu Tyr Ala Val 
            100                 105                 110         


Val Lys Glu His Ile Arg Thr Glu Val Lys Asp Phe Gln Pro Tyr Phe 
        115                 120                 125             


Lys Gly Glu Ile Phe Leu Asp Glu Lys Lys Lys Phe Tyr Gly Pro Gln 
    130                 135                 140                 


Arg Arg Lys Met Met Phe Met Gly Phe Ile Arg Leu Gly Val Trp Tyr 
145                 150                 155                 160 


Asn Phe Phe Arg Ala Trp Asn Gly Gly Phe Ser Gly Asn Leu Glu Gly 
                165                 170                 175     


Glu Gly Phe Ile Leu Gly Gly Val Phe Val Val Gly Ser Gly Lys Gln 
            180                 185                 190         


Gly Ile Leu Leu Glu His Arg Glu Lys Glu Phe Gly Asp Lys Val Asn 
        195                 200                 205             


Leu Leu Ser Val Leu Glu Ala Ala Lys Met Ile Lys Pro Gln Thr Leu 
    210                 215                 220                 


Ala Ser Glu Lys Lys 
225                 


<210>  5332
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  5332

Met Ser Thr Ser Thr Ser Pro Ala Ala Met Leu Leu Arg Arg Leu Arg 
1               5                   10                  15      


Arg Leu Ser Trp Gly Ser Thr Ala Val Gln Leu Phe Ile Leu Thr Val 
            20                  25                  30          


Val Thr Phe Gly Leu Leu Ala Pro Leu Ala Cys His Arg Leu Leu His 
        35                  40                  45              


Ser Tyr Phe Tyr Leu Arg His Trp His Leu Asn Gln Met Ser Gln Glu 
    50                  55                  60                  


Phe Leu Gln Gln Ser Leu Lys Glu Gly Glu Ala Ala Leu His Tyr Phe 
65                  70                  75                  80  


Glu Glu Leu Pro Ser Ala Asn Gly Ser Val Pro Ile Val Trp Gln Ala 
                85                  90                  95      


Thr Pro Arg Pro Trp Leu Val Ile Thr Ile Ile Thr Val Asp Arg Gln 
            100                 105                 110         


Pro Gly Phe His Tyr Val Leu Gln Val Val Ser Gln Phe His Arg Leu 
        115                 120                 125             


Leu Gln Gln Cys Gly Pro Gln Cys Glu Gly His Gln Leu Phe Leu Cys 
    130                 135                 140                 


Asn Val Glu Arg Ser Val Ser His Phe Asp Ala Lys Leu Leu Ser Lys 
145                 150                 155                 160 


Tyr Val Pro Val Ala Asn Arg Tyr Glu Gly Thr Glu Asp Asp Tyr Gly 
                165                 170                 175     


Asp Asp Pro Ser Thr Asn Ser Phe Glu Lys Glu Lys Gln Asp Tyr Val 
            180                 185                 190         


Tyr Cys Leu Glu Ser Ser Leu Gln Thr Tyr Asn Pro Asp Tyr Val Leu 
        195                 200                 205             


Met Val Glu Asp Asp Ala Val Pro Glu Glu Gln Ile Phe Pro Val Leu 
    210                 215                 220                 


Glu His Leu Leu Arg Ala Arg Phe Ser Glu Pro His Leu Arg Asp Ala 
225                 230                 235                 240 


Leu Tyr Leu Lys Leu Tyr His Pro Glu Arg Leu Gln His Tyr Ile Asn 
                245                 250                 255     


Pro Glu Pro Met Arg Ile Leu Glu Trp Val Gly Val Gly Met Leu Leu 
            260                 265                 270         


Gly Pro Leu Leu Thr Trp Ile Tyr Met Arg Phe Ala Ser Arg Pro Gly 
        275                 280                 285             


Phe Ser Trp Pro Val Met Leu Phe Phe Ser Leu Tyr Ser Met Gly Leu 
    290                 295                 300                 


Val Glu Leu Val Gly Arg His Tyr Phe Leu Glu Leu Arg Arg Leu Ser 
305                 310                 315                 320 


Pro Ser Leu Tyr Ser Val Val Pro Ala Ser Gln Cys Cys Thr Pro Ala 
                325                 330                 335     


Met Leu Phe Pro Ala Pro Ala Ala Arg Arg Thr Leu Thr Tyr Leu Ser 
            340                 345                 350         


Gln Val Tyr Cys His Lys Gly Phe Gly Lys Asp Met Ala Leu Tyr Ser 
        355                 360                 365             


Leu Leu Arg Ala Lys Gly Glu Arg Ala Tyr Val Val Glu Pro Asn Leu 
    370                 375                 380                 


Val Lys His Ile Gly Leu Phe Ser Ser Leu Arg Tyr Asn Phe His Pro 
385                 390                 395                 400 


Ser Leu Leu 
            


<210>  5333
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  5333

Met Gly Arg Val Ser Gly Leu Val Pro Ser Arg Phe Leu Thr Leu Leu 
1               5                   10                  15      


Ala His Leu Val Val Val Ile Thr Leu Phe Trp Ser Arg Asp Ser Asn 
            20                  25                  30          


Ile Gln Ala Cys Leu Pro Leu Thr Phe Thr Pro Glu Glu Tyr Asp Lys 
        35                  40                  45              


Gln Asp Ile His Pro Leu Pro Leu Cys Arg Leu Val Ala Ala Leu Ser 
    50                  55                  60                  


Val Thr Leu Gly Leu Phe Ala Val Glu Leu Ala Gly Phe Leu Ser Gly 
65                  70                  75                  80  


Val Ser Met Phe Asn Ser Thr Gln Ser Leu Ile Ser Ile Gly Ala His 
                85                  90                  95      


Cys Ser Ala Ser Val Ala Leu Ser Phe Phe Ile Phe Glu Arg Trp Glu 
            100                 105                 110         


Cys Thr Thr Tyr Trp Tyr Ile Phe Val Phe Cys Ser Ala Leu Pro Ala 
        115                 120                 125             


Val Thr Glu Met Ala Leu Phe Val Thr Val Phe Gly Leu Lys Lys Lys 
    130                 135                 140                 


Pro Phe 
145     


<210>  5334
<211>  702
<212>  PRT
<213>  Homo sapiens

<400>  5334

Met Ala Gln Lys His Pro Gly Glu Arg Gly Leu Tyr Gly Ala His His 
1               5                   10                  15      


Ser Gly Gly Ala Ser Leu Arg Thr Leu Gly Pro Ser Val Asp Pro Glu 
            20                  25                  30          


Ile Pro Ser Phe Ser Gly Leu Arg Asp Ser Ala Gly Thr Ala Pro Asn 
        35                  40                  45              


Gly Thr Arg Cys Leu Thr Glu His Ser Gly Pro Lys His Thr Gln His 
    50                  55                  60                  


Pro Asn Pro Ala His Trp Leu Asp Pro Ser His Gly Pro Pro Gly Gly 
65                  70                  75                  80  


Pro Gly Pro Pro Arg Asp Ala Glu Asp Pro Asp Gln Ser Glu Thr Ser 
                85                  90                  95      


Ser Glu Glu Glu Ser Gly Val Asp Gln Glu Leu Ser Lys Glu Asn Glu 
            100                 105                 110         


Thr Gly Asn Gln Lys Asp Gly Asn Ser Phe Leu Ser Ile Pro Ser Ala 
        115                 120                 125             


Cys Asn Cys Gln Gly Thr Pro Gly Ile Pro Glu Gly Pro Tyr Ser Glu 
    130                 135                 140                 


Gly Gly Asn Gly Ser Ser Ser Asn Phe Cys His His Cys Thr Ser Pro 
145                 150                 155                 160 


Ala Leu Gly Glu Asp Glu Leu Glu Glu Glu Tyr Asp Asp Glu Glu Ser 
                165                 170                 175     


Leu Lys Phe Pro Ser Asp Phe Ser Arg Val Ser Ser Gly Lys Lys Pro 
            180                 185                 190         


Pro Ser Arg Arg Gln Arg His Arg Phe Pro Thr Lys Glu Asp Thr Arg 
        195                 200                 205             


Glu Gly Gly Arg Arg Asp Pro Arg Ser Pro Gly Arg His Arg Leu Gly 
    210                 215                 220                 


Arg Lys Arg Ser Gln Ala Asp Lys Arg Lys Gly Leu Gly Leu Trp Gly 
225                 230                 235                 240 


Ala Glu Glu Leu Cys Gln Leu Gly Gln Ala Gly Phe Trp Trp Leu Ile 
                245                 250                 255     


Glu Leu Leu Val Leu Val Gly Glu Tyr Val Glu Thr Cys Gly His Leu 
            260                 265                 270         


Ile Tyr Ala Cys Arg Gln Leu Lys Ser Ser Asp Leu Asp Leu Phe Arg 
        275                 280                 285             


Val Trp Met Gly Val Trp Thr Gly Arg Leu Gly Gly Trp Ala Gln Val 
    290                 295                 300                 


Met Phe Gln Phe Leu Ser Gln Gly Phe Tyr Cys Gly Val Gly Leu Phe 
305                 310                 315                 320 


Thr Arg Phe Leu Lys Leu Leu Gly Ala Leu Leu Leu Leu Ala Leu Ala 
                325                 330                 335     


Leu Phe Leu Gly Phe Leu Gln Leu Gly Trp Arg Phe Leu Val Gly Leu 
            340                 345                 350         


Gly Asp Arg Leu Gly Trp Arg Asp Lys Ala Thr Trp Leu Phe Ser Trp 
        355                 360                 365             


Leu Asp Ser Pro Ala Leu Gln Arg Cys Leu Thr Leu Leu Arg Asp Ser 
    370                 375                 380                 


Arg Pro Trp Gln Arg Leu Val Arg Ile Val Gln Trp Gly Trp Leu Glu 
385                 390                 395                 400 


Leu Pro Trp Val Lys Gln Asn Ile Asn Arg Gln Gly Asn Ala Pro Val 
                405                 410                 415     


Ala Ser Gly Arg Tyr Cys Gln Pro Glu Glu Glu Val Ala Arg Leu Leu 
            420                 425                 430         


Thr Met Ala Gly Val Pro Glu Asp Glu Leu Asn Pro Phe His Val Leu 
        435                 440                 445             


Gly Val Glu Ala Thr Ala Ser Asp Val Glu Leu Lys Lys Ala Tyr Arg 
    450                 455                 460                 


Gln Leu Ala Val Met Val His Pro Asp Lys Asn His His Pro Arg Ala 
465                 470                 475                 480 


Glu Glu Ala Phe Lys Val Leu Arg Ala Ala Trp Asp Ile Val Ser Asn 
                485                 490                 495     


Ala Glu Lys Arg Lys Glu Tyr Glu Met Lys Arg Met Ala Glu Asn Glu 
            500                 505                 510         


Leu Ser Arg Ser Val Asn Glu Phe Leu Ser Lys Leu Gln Asp Asp Leu 
        515                 520                 525             


Lys Glu Ala Met Asn Thr Met Met Cys Ser Arg Cys Gln Gly Lys His 
    530                 535                 540                 


Arg Arg Phe Glu Met Asp Arg Glu Pro Lys Ser Ala Arg Tyr Cys Ala 
545                 550                 555                 560 


Glu Cys Asn Arg Leu His Pro Ala Glu Glu Gly Asp Phe Trp Ala Glu 
                565                 570                 575     


Ser Ser Met Leu Gly Leu Lys Ile Thr Tyr Phe Ala Leu Met Asp Gly 
            580                 585                 590         


Lys Val Tyr Asp Ile Thr Glu Trp Ala Gly Cys Gln Arg Val Gly Ile 
        595                 600                 605             


Ser Pro Asp Thr His Arg Val Pro Tyr His Ile Ser Phe Gly Ser Arg 
    610                 615                 620                 


Ile Pro Gly Thr Arg Gly Arg Gln Arg Ala Thr Pro Asp Ala Pro Pro 
625                 630                 635                 640 


Ala Asp Leu Gln Asp Phe Leu Ser Arg Ile Phe Gln Val Pro Pro Gly 
                645                 650                 655     


Gln Met Pro Asn Gly Asn Phe Phe Ala Ala Pro Gln Pro Ala Pro Gly 
            660                 665                 670         


Ala Ala Ala Ala Ser Lys Pro Asn Ser Thr Val Pro Lys Gly Glu Ala 
        675                 680                 685             


Lys Pro Lys Arg Arg Lys Lys Val Arg Arg Pro Phe Gln Arg 
    690                 695                 700         


<210>  5335
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  5335

Met Ala Thr Trp Asp Glu Lys Ala Val Thr Arg Arg Ala Lys Val Ala 
1               5                   10                  15      


Pro Ala Glu Arg Met Ser Lys Phe Leu Arg His Phe Thr Val Val Gly 
            20                  25                  30          


Asp Asp Tyr His Ala Trp Asn Ile Asn Tyr Lys Lys Trp Glu Asn Glu 
        35                  40                  45              


Glu Glu Glu Glu Glu Glu Glu Gln Pro Pro Pro Thr Pro Val Ser Gly 
    50                  55                  60                  


Glu Glu Gly Arg Ala Ala Ala Pro Asp Val Ala Pro Ala Pro Gly Pro 
65                  70                  75                  80  


Ala Pro Arg Ala Pro Leu Asp Phe Arg Gly Met Leu Arg Lys Leu Phe 
                85                  90                  95      


Ser Ser His Arg Phe Gln Val Ile Ile Ile Cys Leu Val Val Leu Asp 
            100                 105                 110         


Ala Leu Leu Val Leu Ala Glu Leu Ile Leu Asp Leu Lys Ile Ile Gln 
        115                 120                 125             


Pro Asp Lys Asn Asn Tyr Ala Ala Met Val Phe His Tyr Met Ser Ile 
    130                 135                 140                 


Thr Ile Leu Val Phe Phe Met Met Glu Ile Ile Phe Lys Leu Phe Val 
145                 150                 155                 160 


Phe Arg Leu Glu Phe Phe His His Lys Phe Glu Ile Leu Asp Ala Val 
                165                 170                 175     


Val Val Val Val Ser Phe Ile Leu Asp Ile Val Leu Leu Phe Gln Glu 
            180                 185                 190         


His Gln Phe Glu Ala Leu Gly Leu Leu Ile Leu Leu Arg Leu Trp Arg 
        195                 200                 205             


Val Ala Arg Ile Ile Asn Gly Ile Ile Ile Ser Val Lys Thr Arg Ser 
    210                 215                 220                 


Glu Arg Gln Leu Leu Arg Leu Lys Gln Met Asn Val Gln Leu Ala Ala 
225                 230                 235                 240 


Lys Ile Gln His Leu Glu Phe Ser Cys Ser Glu Lys Glu Gln Glu Ile 
                245                 250                 255     


Glu Arg Leu Asn Lys Leu Leu Arg Gln His Gly Leu Leu Gly Glu Val 
            260                 265                 270         


Asn 
    


<210>  5336
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  5336

Met Ala Ser Lys Ile Gly Ser Arg Arg Trp Met Leu Gln Leu Ile Met 
1               5                   10                  15      


Gln Leu Gly Ser Val Leu Leu Thr Arg Cys Pro Phe Trp Gly Cys Phe 
            20                  25                  30          


Ser Gln Leu Met Leu Tyr Ala Glu Arg Ala Glu Ala Arg Arg Lys Pro 
        35                  40                  45              


Asp Ile Pro Val Pro Tyr Leu Tyr Phe Asp Met Gly Ala Ala Val Leu 
    50                  55                  60                  


Cys Ala Ser Phe Met Ser Phe Gly Val Lys Arg Arg Trp Phe Ala Leu 
65                  70                  75                  80  


Gly Ala Ala Leu Gln Leu Ala Ile Ser Thr Tyr Ala Ala Tyr Ile Gly 
                85                  90                  95      


Gly Tyr Val His Tyr Gly Asp Trp Leu Lys Val Arg Met Tyr Ser Arg 
            100                 105                 110         


Thr Val Ala Ile Ile Gly Gly Phe Leu Val Leu Ala Ser Gly Ala Gly 
        115                 120                 125             


Glu Leu Tyr Arg Arg Lys Pro Arg Ser Arg Ser Leu Gln Ser Thr Gly 
    130                 135                 140                 


Gln Val Phe Leu Gly Ile Tyr Leu Ile Cys Val Ala Tyr Ser Leu Gln 
145                 150                 155                 160 


His Ser Lys Glu Asp Arg Leu Ala Tyr Leu Asn His Leu Pro Gly Gly 
                165                 170                 175     


Glu Leu Met Ile Gln Leu Phe Phe Val Leu Tyr Gly Ile Leu Ala Leu 
            180                 185                 190         


Ala Phe Leu Ser Gly Tyr Tyr Val Thr Leu Ala Ala Gln Ile Leu Ala 
        195                 200                 205             


Val Leu Leu Pro Pro Val Met Leu Leu Ile Asp Gly Asn Val Ala Tyr 
    210                 215                 220                 


Trp His Asn Thr Arg Arg Val Glu Phe Trp Asn Gln Met Lys Leu Leu 
225                 230                 235                 240 


Gly Glu Ser Val Gly Ile Phe Gly Thr Ala Val Ile Leu Ala Thr Asp 
                245                 250                 255     


Gly 
    


<210>  5337
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  5337

Met Lys Gly Glu Ala Gly His Met Leu His Asn Glu Lys Ser Lys Gln 
1               5                   10                  15      


Glu Gly His Ile Trp Gly Ser Met Arg Arg Thr Ala Phe Ile Leu Gly 
            20                  25                  30          


Ser Gly Leu Leu Ser Phe Val Ala Phe Trp Asn Ser Val Thr Trp His 
        35                  40                  45              


Leu Gln Arg Phe Trp Gly Ala Ser Gly Tyr Phe Trp Gln Ala Gln Trp 
    50                  55                  60                  


Glu Arg Leu Leu Thr Thr Phe Glu Gly Lys Glu Trp Ile Leu Phe Phe 
65                  70                  75                  80  


Ile Gly Ala Ile Gln Val Pro Cys Leu Phe Phe Trp Ser Phe Asn Gly 
                85                  90                  95      


Leu Leu Leu Val Val Asp Thr Thr Gly Lys Pro Asn Phe Ile Ser Arg 
            100                 105                 110         


Tyr Arg Ile Gln Val Gly Lys Asn Glu Pro Val Asp Pro Val Lys Leu 
        115                 120                 125             


Arg Gln Ser Ile Arg Thr Val Leu Phe Asn Gln Cys Met Ile Ser Phe 
    130                 135                 140                 


Pro Met Val Val Phe Leu Tyr Pro Phe Leu Lys Trp Trp Arg Asp Pro 
145                 150                 155                 160 


Cys Arg Arg Glu Leu Pro Thr Phe His Trp Phe Leu Leu Glu Leu Ala 
                165                 170                 175     


Ile Phe Thr Leu Ile Glu Glu Val Leu Phe Tyr Tyr Ser His Arg Leu 
            180                 185                 190         


Leu His His Pro Thr Phe Tyr Lys Lys Ile His Lys Lys His His Glu 
        195                 200                 205             


Trp Thr Ala Pro Ile Gly Val Ile Ser Leu Tyr Ala His Pro Ile Glu 
    210                 215                 220                 


His Ala Val Ser Asn Met Leu Pro Val Ile Val Gly Pro Leu Val Met 
225                 230                 235                 240 


Gly Ser His Leu Ser Ser Ile Thr Met Trp Phe Ser Leu Ala Leu Ile 
                245                 250                 255     


Ile Thr Thr Ile Ser His Cys Gly Tyr His Leu Pro Phe Leu Pro Ser 
            260                 265                 270         


Pro Glu Phe His Asp Tyr His His Leu Lys Phe Asn Gln Cys Tyr Gly 
        275                 280                 285             


Val Leu Gly Val Leu Asp His Leu His Gly Thr Asp Thr Met Phe Lys 
    290                 295                 300                 


Gln Thr Lys Ala Tyr Glu Arg His Val Leu Leu Leu Gly Phe Thr Pro 
305                 310                 315                 320 


Leu Ser Glu Ser Ile Pro Asp Ser Pro Lys Arg Met Glu 
                325                 330             


<210>  5338
<211>  934
<212>  PRT
<213>  Homo sapiens

<400>  5338

Met Val Pro Glu Ala Trp Arg Ser Gly Leu Val Ser Thr Gly Arg Val 
1               5                   10                  15      


Val Gly Val Leu Leu Leu Leu Gly Ala Leu Asn Lys Ala Ser Thr Val 
            20                  25                  30          


Ile His Tyr Glu Ile Pro Glu Glu Arg Glu Lys Gly Phe Ala Val Gly 
        35                  40                  45              


Asn Val Val Ala Asn Leu Gly Leu Asp Leu Gly Ser Leu Ser Ala Arg 
    50                  55                  60                  


Arg Phe Arg Val Val Ser Gly Ala Ser Arg Arg Phe Phe Glu Val Asn 
65                  70                  75                  80  


Arg Glu Thr Gly Glu Met Phe Val Asn Asp Arg Leu Asp Arg Glu Glu 
                85                  90                  95      


Leu Cys Gly Thr Leu Pro Ser Cys Thr Val Thr Leu Glu Leu Val Val 
            100                 105                 110         


Glu Asn Pro Leu Glu Leu Phe Ser Val Glu Val Val Ile Gln Asp Ile 
        115                 120                 125             


Asn Asp Asn Asn Pro Ala Phe Pro Thr Gln Glu Met Lys Leu Glu Ile 
    130                 135                 140                 


Ser Glu Ala Val Ala Pro Gly Thr Arg Phe Pro Leu Glu Ser Ala His 
145                 150                 155                 160 


Asp Pro Asp Val Gly Ser Asn Ser Leu Gln Thr Tyr Glu Leu Ser Arg 
                165                 170                 175     


Asn Glu Tyr Phe Ala Leu Arg Val Gln Thr Arg Glu Asp Ser Thr Lys 
            180                 185                 190         


Tyr Ala Glu Leu Val Leu Glu Arg Ala Leu Asp Arg Glu Arg Glu Pro 
        195                 200                 205             


Ser Leu Gln Leu Val Leu Thr Ala Leu Asp Gly Gly Thr Pro Ala Leu 
    210                 215                 220                 


Ser Ala Ser Leu Pro Ile His Ile Lys Val Leu Asp Ala Asn Asp Asn 
225                 230                 235                 240 


Ala Pro Val Phe Asn Gln Ser Leu Tyr Arg Ala Arg Val Leu Glu Asp 
                245                 250                 255     


Ala Pro Ser Gly Thr Arg Val Val Gln Val Leu Ala Thr Asp Leu Asp 
            260                 265                 270         


Glu Gly Pro Asn Gly Glu Ile Ile Tyr Ser Phe Gly Ser His Asn Arg 
        275                 280                 285             


Ala Gly Val Arg Gln Leu Phe Ala Leu Asp Leu Val Thr Gly Met Leu 
    290                 295                 300                 


Thr Ile Lys Gly Arg Leu Asp Phe Glu Asp Thr Lys Leu His Glu Ile 
305                 310                 315                 320 


Tyr Ile Gln Ala Lys Asp Lys Gly Ala Asn Pro Glu Gly Ala His Cys 
                325                 330                 335     


Lys Val Leu Val Glu Val Val Asp Val Asn Asp Asn Ala Pro Glu Ile 
            340                 345                 350         


Thr Val Thr Ser Val Tyr Ser Pro Val Pro Glu Asp Ala Pro Leu Gly 
        355                 360                 365             


Thr Val Ile Ala Leu Leu Ser Val Thr Asp Leu Asp Ala Gly Glu Asn 
    370                 375                 380                 


Gly Leu Val Thr Cys Glu Val Pro Pro Gly Leu Pro Phe Ser Leu Thr 
385                 390                 395                 400 


Ser Ser Leu Lys Asn Tyr Phe Thr Leu Lys Thr Ser Ala Asp Leu Asp 
                405                 410                 415     


Arg Glu Thr Val Pro Glu Tyr Asn Leu Ser Ile Thr Ala Arg Asp Ala 
            420                 425                 430         


Gly Thr Pro Ser Leu Ser Ala Leu Thr Ile Val Arg Val Gln Val Ser 
        435                 440                 445             


Asp Ile Asn Asp Asn Pro Pro Gln Ser Ser Gln Ser Ser Tyr Asp Val 
    450                 455                 460                 


Tyr Ile Glu Glu Asn Asn Leu Pro Gly Ala Pro Ile Leu Asn Leu Ser 
465                 470                 475                 480 


Val Trp Asp Pro Asp Ala Pro Gln Asn Ala Arg Leu Ser Phe Phe Leu 
                485                 490                 495     


Leu Glu Gln Gly Ala Glu Thr Gly Leu Val Gly Arg Tyr Phe Thr Ile 
            500                 505                 510         


Asn Arg Asp Asn Gly Ile Val Ser Ser Leu Val Pro Leu Asp Tyr Glu 
        515                 520                 525             


Asp Arg Arg Glu Phe Glu Leu Thr Ala His Ile Ser Asp Gly Gly Thr 
    530                 535                 540                 


Pro Val Leu Ala Thr Asn Ile Ser Val Asn Ile Phe Val Thr Asp Arg 
545                 550                 555                 560 


Asn Asp Asn Ala Pro Gln Val Leu Tyr Pro Arg Pro Gly Gly Ser Ser 
                565                 570                 575     


Val Glu Met Leu Pro Arg Gly Thr Ser Ala Gly His Leu Val Ser Arg 
            580                 585                 590         


Val Val Gly Trp Asp Ala Asp Ala Gly His Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Ser Leu Leu Gly Ser Pro Asn Gln Ser Leu Phe Ala Ile Gly Leu His 
    610                 615                 620                 


Thr Gly Gln Ile Ser Thr Ala Arg Pro Val Gln Asp Thr Asp Ser Pro 
625                 630                 635                 640 


Arg Gln Thr Leu Thr Val Leu Ile Lys Asp Asn Gly Glu Pro Ser Leu 
                645                 650                 655     


Ser Thr Thr Ala Thr Leu Thr Val Ser Val Thr Glu Asp Ser Pro Glu 
            660                 665                 670         


Ala Arg Ala Glu Phe Pro Ser Gly Ser Ala Pro Arg Glu Gln Lys Lys 
        675                 680                 685             


Asn Leu Thr Phe Tyr Leu Leu Leu Ser Leu Ile Leu Val Ser Val Gly 
    690                 695                 700                 


Phe Val Val Thr Val Phe Gly Val Ile Ile Phe Lys Val Tyr Lys Trp 
705                 710                 715                 720 


Lys Gln Ser Arg Asp Leu Tyr Arg Ala Pro Val Ser Ser Leu Tyr Arg 
                725                 730                 735     


Thr Pro Gly Pro Ser Leu His Ala Asp Ala Val Arg Gly Gly Leu Met 
            740                 745                 750         


Ser Pro His Leu Tyr His Gln Val Tyr Leu Thr Thr Asp Ser Arg Arg 
        755                 760                 765             


Ser Asp Pro Leu Leu Lys Lys Pro Gly Ala Ala Ser Pro Leu Ala Ser 
    770                 775                 780                 


Arg Gln Asn Thr Leu Arg Ser Cys Asp Pro Val Phe Tyr Arg Gln Val 
785                 790                 795                 800 


Leu Gly Ala Glu Ser Ala Pro Pro Gly Gln Gln Ala Pro Pro Asn Thr 
                805                 810                 815     


Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln 
            820                 825                 830         


Asn Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu 
        835                 840                 845             


Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly 
    850                 855                 860                 


Ser Ser Thr Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg 
865                 870                 875                 880 


Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn 
                885                 890                 895     


Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys 
            900                 905                 910         


Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser 
        915                 920                 925             


Gly Lys Lys Glu Lys Lys 
    930                 


<210>  5339
<211>  938
<212>  PRT
<213>  Homo sapiens

<400>  5339

Met Leu Arg Lys Val Arg Ser Trp Thr Glu Ile Trp Arg Trp Ala Thr 
1               5                   10                  15      


Leu Leu Phe Leu Phe Tyr His Leu Gly Tyr Val Cys Gly Gln Ile Arg 
            20                  25                  30          


Tyr Pro Val Pro Glu Glu Ser Gln Glu Gly Thr Phe Val Gly Asn Val 
        35                  40                  45              


Ala Gln Asp Phe Leu Leu Asp Thr Asp Ser Leu Ser Ala Arg Arg Leu 
    50                  55                  60                  


Gln Val Ala Gly Glu Val Asn Gln Arg His Phe Arg Val Asp Leu Asp 
65                  70                  75                  80  


Ser Gly Ala Leu Leu Ile Lys Asn Pro Ile Asp Arg Glu Ala Leu Cys 
                85                  90                  95      


Gly Leu Ser Ala Ser Cys Ile Val Pro Leu Glu Phe Val Thr Glu Gly 
            100                 105                 110         


Pro Leu Glu Met Tyr Arg Ala Glu Val Glu Ile Val Asp Val Asn Asp 
        115                 120                 125             


His Ala Pro Arg Phe Pro Arg Gln Gln Leu Asp Leu Glu Ile Gly Glu 
    130                 135                 140                 


Ala Ala Pro Pro Gly Gln Arg Phe Pro Leu Glu Lys Ala Gln Asp Ala 
145                 150                 155                 160 


Asp Val Gly Ser Asn Ser Ile Ser Ser Tyr Arg Leu Ser Ser Asn Glu 
                165                 170                 175     


His Phe Ala Leu Asp Val Lys Lys Arg Ser Asp Gly Ser Leu Val Pro 
            180                 185                 190         


Glu Leu Leu Leu Glu Lys Pro Leu Asp Arg Glu Lys Gln Ser Asp Tyr 
        195                 200                 205             


Arg Leu Val Leu Thr Ala Val Asp Gly Gly Asn Pro Pro Arg Ser Gly 
    210                 215                 220                 


Thr Ala Glu Leu Arg Val Ser Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Ala Phe Gln Gln Ser Ser Tyr Arg Ile Ser Val Leu Glu Ser Ala Pro 
                245                 250                 255     


Ala Gly Met Val Leu Ile Gln Leu Asn Ala Ser Asp Pro Asp Leu Gly 
            260                 265                 270         


Pro Ser Gly Asn Val Thr Phe Tyr Phe Ser Gly His Thr Pro Asp Arg 
        275                 280                 285             


Val Arg Asn Leu Phe Ser Leu His Pro Thr Thr Gly Lys Leu Thr Leu 
    290                 295                 300                 


Leu Gly Pro Leu Asp Phe Glu Ser Glu Asn Tyr Tyr Glu Phe Asp Val 
305                 310                 315                 320 


Arg Ala Arg Asp Gly Gly Ser Pro Ala Met Glu Gln His Cys Ser Leu 
                325                 330                 335     


Arg Val Asp Leu Leu Asp Val Asn Asp Asn Ala Pro Tyr Ile Thr Val 
            340                 345                 350         


Thr Ser Glu Leu Gly Thr Leu Pro Glu Ser Ala Glu Pro Gly Thr Val 
        355                 360                 365             


Val Ala Leu Ile Ser Val Gln Asp Pro Asp Ser Gly Ser Asn Gly Asp 
    370                 375                 380                 


Val Ser Leu Arg Ile Pro Asp His Leu Pro Phe Ala Leu Lys Ser Ala 
385                 390                 395                 400 


Phe Arg Asn Gln Phe Ser Leu Val Thr Ala Gly Pro Leu Asp Arg Glu 
                405                 410                 415     


Ala Lys Ser Ser Tyr Asp Ile Met Val Thr Ala Ser Asp Ala Gly Asn 
            420                 425                 430         


Pro Pro Leu Ser Thr His Arg Thr Ile Phe Leu Asn Ile Ser Asp Val 
        435                 440                 445             


Asn Asp Asn Pro Pro Ser Phe Phe Gln Arg Ser His Glu Val Phe Val 
    450                 455                 460                 


Pro Glu Asn Asn Arg Pro Gly Asp Leu Leu Cys Ser Leu Ala Ala Ser 
465                 470                 475                 480 


Asp Pro Asp Ser Gly Leu Asn Ala Leu Ile Ser Tyr Ser Leu Leu Glu 
                485                 490                 495     


Pro Arg Asn Arg Asp Val Ser Ala Ser Ser Phe Ile Ser Leu Asn Pro 
            500                 505                 510         


Gln Thr Gly Ala Val His Ala Thr Arg Ser Phe Asp Tyr Glu Gln Thr 
        515                 520                 525             


Gln Thr Leu Gln Phe Glu Val Gln Ala Arg Asp Arg Gly Asn Pro Pro 
    530                 535                 540                 


Leu Ser Ser Thr Val Thr Val Arg Leu Phe Val Leu Asp Leu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Val Leu Arg Pro Arg Ala Arg Pro Gly Ser Leu Cys 
                565                 570                 575     


Pro Gln Ala Leu Pro Pro Ser Val Gly Ala Gly His Leu Ile Thr Lys 
            580                 585                 590         


Val Thr Ala Val Asp Leu Asp Ser Gly Tyr Asn Ala Trp Val Ser Tyr 
        595                 600                 605             


Gln Leu Leu Glu Ala Pro Asp Pro Ser Leu Phe Ala Val Ser Arg Tyr 
    610                 615                 620                 


Ala Gly Glu Val Arg Thr Ala Val Pro Ile Pro Ala Asp Leu Pro Pro 
625                 630                 635                 640 


Gln Lys Leu Val Ile Val Val Lys Asp Ser Gly Ser Pro Pro Leu Ser 
                645                 650                 655     


Thr Ser Val Thr Leu Leu Val Ser Leu Glu Glu Asp Thr His Pro Val 
            660                 665                 670         


Val Pro Asp Leu Arg Glu Ser Ser Ala Pro Arg Glu Gly Glu Ser Arg 
        675                 680                 685             


Leu Thr Leu Tyr Leu Ala Val Ser Leu Val Ala Ile Cys Phe Val Ser 
    690                 695                 700                 


Phe Gly Ser Phe Val Ala Leu Leu Ser Lys Cys Leu Arg Gly Ala Ala 
705                 710                 715                 720 


Cys Gly Val Thr Cys Phe Pro Ala Gly Thr Cys Ala Cys Leu Thr Arg 
                725                 730                 735     


Ser Arg Arg Arg Glu Gly Leu Pro Pro Ser Asn Gly Ile Leu Arg Ile 
            740                 745                 750         


Gln Leu Gly Ser Asp Asp Pro Ile Lys Phe Val Asp Val Gly Gly His 
        755                 760                 765             


Ser His Gly Cys Thr Pro Leu Ala Ser Ala Pro Thr Arg Ser Asp Ser 
    770                 775                 780                 


Phe Met Met Val Lys Ser Pro Ser Ala Pro Met Ala Gly Glu Pro Val 
785                 790                 795                 800 


Arg Pro Ser Cys Pro Pro Ser Asp Leu Leu Tyr Gly Leu Glu Gln Ala 
                805                 810                 815     


Pro Pro Asn Thr Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr 
            820                 825                 830         


Ser Gly Ser Gln Asn Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln 
        835                 840                 845             


Phe Asp Thr Glu Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser Glu 
    850                 855                 860                 


Ala Ala Asp Gly Ser Ser Thr Leu Gly Gly Gly Ala Gly Thr Met Gly 
865                 870                 875                 880 


Leu Ser Ala Arg Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro Asp 
                885                 890                 895     


Tyr Arg Gln Asn Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn 
            900                 905                 910         


Ala Ala Gly Lys Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn 
        915                 920                 925             


Lys Lys Lys Ser Gly Lys Lys Glu Lys Lys 
    930                 935             


<210>  5340
<211>  944
<212>  PRT
<213>  Homo sapiens

<400>  5340

Met Gly Pro Lys Thr Leu Pro Gln Leu Ala Gly Lys Trp Gln Val Leu 
1               5                   10                  15      


Cys Met Leu Ser Leu Cys Cys Trp Gly Trp Val Ser Gly Gln Leu Arg 
            20                  25                  30          


Tyr Ser Val Val Glu Glu Ser Glu Pro Gly Thr Leu Val Gly Asn Val 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Lys Met Thr Asp Leu Leu Ser Arg Arg Leu 
    50                  55                  60                  


Gln Leu Gly Ser Glu Glu Asn Gly Arg Tyr Phe Ser Leu Ser Leu Met 
65                  70                  75                  80  


Ser Gly Ala Leu Ala Val Asn Gln Lys Ile Asp Arg Glu Ser Leu Cys 
                85                  90                  95      


Gly Ala Ser Thr Ser Cys Leu Leu Pro Val Gln Val Val Thr Glu His 
            100                 105                 110         


Pro Leu Glu Leu Ile Arg Val Glu Val Glu Ile Leu Asp Leu Asn Asp 
        115                 120                 125             


Asn Ser Pro Ser Phe Ala Thr Pro Glu Arg Glu Met Arg Ile Ser Glu 
    130                 135                 140                 


Ser Ala Ala Ser Gly Ala Arg Phe Pro Leu Asp Ser Ala Gln Asp Pro 
145                 150                 155                 160 


Asp Val Gly Thr Asn Thr Val Ser Phe Tyr Thr Leu Ser Pro Asn Ser 
                165                 170                 175     


His Phe Ser Leu Asn Val Lys Thr Leu Lys Asp Gly Lys Pro Phe Pro 
            180                 185                 190         


Glu Leu Val Leu Glu Gln Gln Leu Asp Arg Glu Ala Gln Ala Arg His 
        195                 200                 205             


Gln Leu Val Leu Thr Ala Val Asp Gly Gly Thr Pro Ala Arg Ser Gly 
    210                 215                 220                 


Thr Thr Leu Ile Ser Val Ile Val Leu Asp Ile Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Thr Phe Gln Ser Ser Val Leu Arg Val Gly Ile Pro Glu Asn Ala Pro 
                245                 250                 255     


Ile Gly Thr Leu Leu Leu Arg Leu Asn Ala Thr Asp Pro Asp Glu Gly 
            260                 265                 270         


Thr Asn Gly Gln Leu Asp Tyr Ser Phe Gly Asp His Thr Ser Glu Ala 
        275                 280                 285             


Val Arg Asn Leu Phe Gly Leu Asp Pro Ser Ser Gly Ala Ile His Val 
    290                 295                 300                 


Leu Gly Pro Ile Asp Phe Glu Glu Ser Arg Phe Tyr Glu Ile His Ala 
305                 310                 315                 320 


Arg Ala Arg Asp Gln Gly Gln Pro Ala Met Glu Gly His Cys Val Ile 
                325                 330                 335     


Gln Val Asp Val Gly Asp Val Asn Asp Asn Ala Pro Glu Val Leu Leu 
            340                 345                 350         


Ala Ser Leu Ala Asn Pro Val Leu Glu Ser Thr Pro Val Gly Thr Val 
        355                 360                 365             


Val Gly Leu Phe Asn Val Arg Asp Arg Asp Ser Gly Arg Asn Gly Glu 
    370                 375                 380                 


Val Ser Leu Asp Ile Ser Pro Asp Leu Pro Phe Gln Ile Lys Pro Ser 
385                 390                 395                 400 


Glu Asn His Tyr Ser Leu Leu Thr Ser Gln Pro Leu Asp Arg Glu Ala 
                405                 410                 415     


Thr Ser His Tyr Ile Ile Glu Leu Leu Ala Ser Asp Ala Gly Ser Pro 
            420                 425                 430         


Ser Leu His Lys His Leu Thr Ile Arg Leu Asn Ile Ser Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Arg Phe Asn Gln Gln Leu Tyr Thr Ala Tyr Ile Leu 
    450                 455                 460                 


Glu Asn Arg Pro Pro Gly Ser Leu Leu Cys Thr Val Ala Ala Ser Asp 
465                 470                 475                 480 


Pro Asp Thr Gly Asp Asn Ala Arg Leu Thr Tyr Ser Ile Val Gly Asn 
                485                 490                 495     


Gln Val Gln Gly Ala Pro Ala Ser Ser Phe Val Tyr Val Asn Pro Glu 
            500                 505                 510         


Asp Gly Arg Ile Phe Ala Gln Arg Thr Phe Asp Tyr Glu Leu Leu Gln 
        515                 520                 525             


Met Leu Gln Ile Val Val Gly Val Arg Asp Ser Gly Ser Pro Pro Leu 
    530                 535                 540                 


His Ala Asn Thr Ser Leu His Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Val Leu His Pro Arg Pro Asp Trp Glu His Ser Ala Pro 
                565                 570                 575     


Gln Arg Leu Pro Arg Ser Ala Pro Pro Gly Ser Leu Val Thr Lys Val 
            580                 585                 590         


Thr Ala Val Asp Ala Asp Ala Gly His Asn Ala Trp Leu Ser Tyr Ser 
        595                 600                 605             


Leu Leu Pro Gln Ser Thr Ala Pro Gly Leu Phe Leu Val Ser Thr His 
    610                 615                 620                 


Thr Gly Glu Val Arg Thr Ala Arg Ala Leu Leu Glu Asp Asp Ser Asp 
625                 630                 635                 640 


Thr Gln Gln Val Val Val Leu Val Arg Asp Asn Gly Asp Pro Ser Leu 
                645                 650                 655     


Ser Ser Thr Ala Thr Val Leu Leu Val Leu Glu Asp Glu Asp Pro Glu 
            660                 665                 670         


Glu Met Pro Lys Ser Ser Asp Phe Leu Ile His Pro Pro Glu Arg Ser 
        675                 680                 685             


Asp Leu Thr Leu Tyr Leu Ile Val Ala Leu Ala Thr Val Ser Leu Leu 
    690                 695                 700                 


Ser Leu Val Thr Phe Thr Phe Leu Ser Ala Lys Cys Leu Gln Gly Asn 
705                 710                 715                 720 


Ala Asp Gly Asp Gly Gly Gly Gly Gln Cys Cys Arg Arg Gln Asp Ser 
                725                 730                 735     


Pro Ser Pro Asp Phe Tyr Lys Gln Ser Ser Pro Asn Leu Gln Val Ser 
            740                 745                 750         


Ser Asp Gly Thr Leu Lys Tyr Met Glu Val Thr Leu Arg Pro Thr Asp 
        755                 760                 765             


Ser Gln Ser His Cys Tyr Arg Thr Cys Phe Ser Pro Ala Ser Asp Gly 
    770                 775                 780                 


Ser Asp Phe Thr Phe Leu Arg Pro Leu Ser Val Gln Gln Pro Thr Ala 
785                 790                 795                 800 


Leu Ala Leu Glu Pro Asp Ala Ile Arg Ser Arg Ser Asn Thr Leu Arg 
                805                 810                 815     


Glu Arg Ser Gln Gln Ala Pro Pro Asn Thr Asp Trp Arg Phe Ser Gln 
            820                 825                 830         


Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly Asp Asp Thr Gly 
        835                 840                 845             


Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu Gln Ala Met Ile 
    850                 855                 860                 


Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser Thr Leu Gly Gly 
865                 870                 875                 880 


Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly Pro Gln Phe Thr 
                885                 890                 895     


Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr Ile Pro Gly Ser 
            900                 905                 910         


Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp Gly Lys Ala Pro 
        915                 920                 925             


Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys Lys Glu Lys Lys 
    930                 935                 940                 


<210>  5341
<211>  934
<212>  PRT
<213>  Homo sapiens

<400>  5341

Met Val Pro Glu Ala Trp Arg Ser Gly Leu Val Ser Thr Gly Arg Val 
1               5                   10                  15      


Val Gly Val Leu Leu Leu Leu Gly Ala Leu Asn Lys Ala Ser Thr Val 
            20                  25                  30          


Ile His Tyr Glu Ile Pro Glu Glu Arg Glu Lys Gly Phe Ala Val Gly 
        35                  40                  45              


Asn Val Val Ala Asn Leu Gly Leu Asp Leu Gly Ser Leu Ser Ala Arg 
    50                  55                  60                  


Arg Phe Arg Val Val Ser Gly Ala Ser Arg Arg Phe Phe Glu Val Asn 
65                  70                  75                  80  


Arg Glu Thr Gly Glu Met Phe Val Asn Asp Arg Leu Asp Arg Glu Glu 
                85                  90                  95      


Leu Cys Gly Thr Leu Pro Ser Cys Thr Val Thr Leu Glu Leu Val Val 
            100                 105                 110         


Glu Asn Pro Leu Glu Leu Phe Ser Val Glu Val Val Ile Gln Asp Ile 
        115                 120                 125             


Asn Asp Asn Asn Pro Ala Phe Pro Thr Gln Glu Met Lys Leu Glu Ile 
    130                 135                 140                 


Ser Glu Ala Val Ala Pro Gly Thr Arg Phe Pro Leu Glu Ser Ala His 
145                 150                 155                 160 


Asp Pro Asp Val Gly Ser Asn Ser Leu Gln Thr Tyr Glu Leu Ser Arg 
                165                 170                 175     


Asn Glu Tyr Phe Ala Leu Arg Val Gln Thr Arg Glu Asp Ser Thr Lys 
            180                 185                 190         


Tyr Ala Glu Leu Val Leu Glu Arg Ala Leu Asp Arg Glu Arg Glu Pro 
        195                 200                 205             


Ser Leu Gln Leu Val Leu Thr Ala Leu Asp Gly Gly Thr Pro Ala Leu 
    210                 215                 220                 


Ser Ala Ser Leu Pro Ile His Ile Lys Val Leu Asp Ala Asn Asp Asn 
225                 230                 235                 240 


Ala Pro Val Phe Asn Gln Ser Leu Tyr Arg Ala Arg Val Leu Glu Asp 
                245                 250                 255     


Ala Pro Ser Gly Thr Arg Val Val Gln Val Leu Ala Thr Asp Leu Asp 
            260                 265                 270         


Glu Gly Pro Asn Gly Glu Ile Ile Tyr Ser Phe Gly Ser His Asn Arg 
        275                 280                 285             


Ala Gly Val Arg Gln Leu Phe Ala Leu Asp Leu Val Thr Gly Met Leu 
    290                 295                 300                 


Thr Ile Lys Gly Arg Leu Asp Phe Glu Asp Thr Lys Leu His Glu Ile 
305                 310                 315                 320 


Tyr Ile Gln Ala Lys Asp Lys Gly Ala Asn Pro Glu Gly Ala His Cys 
                325                 330                 335     


Lys Val Leu Val Glu Val Val Asp Val Asn Asp Asn Ala Pro Glu Ile 
            340                 345                 350         


Thr Val Thr Ser Val Tyr Ser Pro Val Pro Glu Asp Ala Pro Leu Gly 
        355                 360                 365             


Thr Val Ile Ala Leu Leu Ser Val Thr Asp Leu Asp Ala Gly Glu Asn 
    370                 375                 380                 


Gly Leu Val Thr Cys Glu Val Pro Pro Gly Leu Pro Phe Ser Leu Thr 
385                 390                 395                 400 


Ser Ser Leu Lys Asn Tyr Phe Thr Leu Lys Thr Ser Ala Asp Leu Asp 
                405                 410                 415     


Arg Glu Thr Val Pro Glu Tyr Asn Leu Ser Ile Thr Ala Arg Asp Ala 
            420                 425                 430         


Gly Thr Pro Ser Leu Ser Ala Leu Thr Ile Val Arg Val Gln Val Ser 
        435                 440                 445             


Asp Ile Asn Asp Asn Pro Pro Gln Ser Ser Gln Ser Ser Tyr Asp Val 
    450                 455                 460                 


Tyr Ile Glu Glu Asn Asn Leu Pro Gly Ala Pro Ile Leu Asn Leu Ser 
465                 470                 475                 480 


Val Trp Asp Pro Asp Ala Pro Gln Asn Ala Arg Leu Ser Phe Phe Leu 
                485                 490                 495     


Leu Glu Gln Gly Ala Glu Thr Gly Leu Val Gly Arg Tyr Phe Thr Ile 
            500                 505                 510         


Asn Arg Asp Asn Gly Ile Val Ser Ser Leu Val Pro Leu Asp Tyr Glu 
        515                 520                 525             


Asp Arg Arg Glu Phe Glu Leu Thr Ala His Ile Ser Asp Gly Gly Thr 
    530                 535                 540                 


Pro Val Leu Ala Thr Asn Ile Ser Val Asn Ile Phe Val Thr Asp Arg 
545                 550                 555                 560 


Asn Asp Asn Ala Pro Gln Val Leu Tyr Pro Arg Pro Gly Gly Ser Ser 
                565                 570                 575     


Val Glu Met Leu Pro Arg Gly Thr Ser Ala Gly His Leu Val Ser Arg 
            580                 585                 590         


Val Val Gly Trp Asp Ala Asp Ala Gly His Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Ser Leu Leu Gly Ser Pro Asn Gln Ser Leu Phe Ala Ile Gly Leu His 
    610                 615                 620                 


Thr Gly Gln Ile Ser Thr Ala Arg Pro Val Gln Asp Thr Asp Ser Pro 
625                 630                 635                 640 


Arg Gln Thr Leu Thr Val Leu Ile Lys Asp Asn Gly Glu Pro Ser Leu 
                645                 650                 655     


Ser Thr Thr Ala Thr Leu Thr Val Ser Val Thr Glu Asp Ser Pro Glu 
            660                 665                 670         


Ala Arg Ala Glu Phe Pro Ser Gly Ser Ala Pro Arg Glu Gln Lys Lys 
        675                 680                 685             


Asn Leu Thr Phe Tyr Leu Leu Leu Ser Leu Ile Leu Val Ser Val Gly 
    690                 695                 700                 


Phe Val Val Thr Val Phe Gly Val Ile Ile Phe Lys Val Tyr Lys Trp 
705                 710                 715                 720 


Lys Gln Ser Arg Asp Leu Tyr Arg Ala Pro Val Ser Ser Leu Tyr Arg 
                725                 730                 735     


Thr Pro Gly Pro Ser Leu His Ala Asp Ala Val Arg Gly Gly Leu Met 
            740                 745                 750         


Ser Pro His Leu Tyr His Gln Val Tyr Leu Thr Thr Asp Ser Arg Arg 
        755                 760                 765             


Ser Asp Pro Leu Leu Lys Lys Pro Gly Ala Ala Ser Pro Leu Ala Ser 
    770                 775                 780                 


Arg Gln Asn Thr Leu Arg Ser Cys Asp Pro Val Phe Tyr Arg Gln Val 
785                 790                 795                 800 


Leu Gly Ala Glu Ser Ala Pro Pro Gly Gln Gln Ala Pro Pro Asn Thr 
                805                 810                 815     


Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln 
            820                 825                 830         


Asn Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu 
        835                 840                 845             


Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly 
    850                 855                 860                 


Ser Ser Thr Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg 
865                 870                 875                 880 


Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn 
                885                 890                 895     


Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys 
            900                 905                 910         


Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser 
        915                 920                 925             


Gly Lys Lys Glu Lys Lys 
    930                 


<210>  5342
<211>  938
<212>  PRT
<213>  Homo sapiens

<400>  5342

Met Leu Arg Lys Val Arg Ser Trp Thr Glu Ile Trp Arg Trp Ala Thr 
1               5                   10                  15      


Leu Leu Phe Leu Phe Tyr His Leu Gly Tyr Val Cys Gly Gln Ile Arg 
            20                  25                  30          


Tyr Pro Val Pro Glu Glu Ser Gln Glu Gly Thr Phe Val Gly Asn Val 
        35                  40                  45              


Ala Gln Asp Phe Leu Leu Asp Thr Asp Ser Leu Ser Ala Arg Arg Leu 
    50                  55                  60                  


Gln Val Ala Gly Glu Val Asn Gln Arg His Phe Arg Val Asp Leu Asp 
65                  70                  75                  80  


Ser Gly Ala Leu Leu Ile Lys Asn Pro Ile Asp Arg Glu Ala Leu Cys 
                85                  90                  95      


Gly Leu Ser Ala Ser Cys Ile Val Pro Leu Glu Phe Val Thr Glu Gly 
            100                 105                 110         


Pro Leu Glu Met Tyr Arg Ala Glu Val Glu Ile Val Asp Val Asn Asp 
        115                 120                 125             


His Ala Pro Arg Phe Pro Arg Gln Gln Leu Asp Leu Glu Ile Gly Glu 
    130                 135                 140                 


Ala Ala Pro Pro Gly Gln Arg Phe Pro Leu Glu Lys Ala Gln Asp Ala 
145                 150                 155                 160 


Asp Val Gly Ser Asn Ser Ile Ser Ser Tyr Arg Leu Ser Ser Asn Glu 
                165                 170                 175     


His Phe Ala Leu Asp Val Lys Lys Arg Ser Asp Gly Ser Leu Val Pro 
            180                 185                 190         


Glu Leu Leu Leu Glu Lys Pro Leu Asp Arg Glu Lys Gln Ser Asp Tyr 
        195                 200                 205             


Arg Leu Val Leu Thr Ala Val Asp Gly Gly Asn Pro Pro Arg Ser Gly 
    210                 215                 220                 


Thr Ala Glu Leu Arg Val Ser Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Ala Phe Gln Gln Ser Ser Tyr Arg Ile Ser Val Leu Glu Ser Ala Pro 
                245                 250                 255     


Ala Gly Met Val Leu Ile Gln Leu Asn Ala Ser Asp Pro Asp Leu Gly 
            260                 265                 270         


Pro Ser Gly Asn Val Thr Phe Tyr Phe Ser Gly His Thr Pro Asp Arg 
        275                 280                 285             


Val Arg Asn Leu Phe Ser Leu His Pro Thr Thr Gly Lys Leu Thr Leu 
    290                 295                 300                 


Leu Gly Pro Leu Asp Phe Glu Ser Glu Asn Tyr Tyr Glu Phe Asp Val 
305                 310                 315                 320 


Arg Ala Arg Asp Gly Gly Ser Pro Ala Met Glu Gln His Cys Ser Leu 
                325                 330                 335     


Arg Val Asp Leu Leu Asp Val Asn Asp Asn Ala Pro Tyr Ile Thr Val 
            340                 345                 350         


Thr Ser Glu Leu Gly Thr Leu Pro Glu Ser Ala Glu Pro Gly Thr Val 
        355                 360                 365             


Val Ala Leu Ile Ser Val Gln Asp Pro Asp Ser Gly Ser Asn Gly Asp 
    370                 375                 380                 


Val Ser Leu Arg Ile Pro Asp His Leu Pro Phe Ala Leu Lys Ser Ala 
385                 390                 395                 400 


Phe Arg Asn Gln Phe Ser Leu Val Thr Ala Gly Pro Leu Asp Arg Glu 
                405                 410                 415     


Ala Lys Ser Ser Tyr Asp Ile Met Val Thr Ala Ser Asp Ala Gly Asn 
            420                 425                 430         


Pro Pro Leu Ser Thr His Arg Thr Ile Phe Leu Asn Ile Ser Asp Val 
        435                 440                 445             


Asn Asp Asn Pro Pro Ser Phe Phe Gln Arg Ser His Glu Val Phe Val 
    450                 455                 460                 


Pro Glu Asn Asn Arg Pro Gly Asp Leu Leu Cys Ser Leu Ala Ala Ser 
465                 470                 475                 480 


Asp Pro Asp Ser Gly Leu Asn Ala Leu Ile Ser Tyr Ser Leu Leu Glu 
                485                 490                 495     


Pro Arg Asn Arg Asp Val Ser Ala Ser Ser Phe Ile Ser Leu Asn Pro 
            500                 505                 510         


Gln Thr Gly Ala Val His Ala Thr Arg Ser Phe Asp Tyr Glu Gln Thr 
        515                 520                 525             


Gln Thr Leu Gln Phe Glu Val Gln Ala Arg Asp Arg Gly Asn Pro Pro 
    530                 535                 540                 


Leu Ser Ser Thr Val Thr Val Arg Leu Phe Val Leu Asp Leu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Val Leu Arg Pro Arg Ala Arg Pro Gly Ser Leu Cys 
                565                 570                 575     


Pro Gln Ala Leu Pro Pro Ser Val Gly Ala Gly His Leu Ile Thr Lys 
            580                 585                 590         


Val Thr Ala Val Asp Leu Asp Ser Gly Tyr Asn Ala Trp Val Ser Tyr 
        595                 600                 605             


Gln Leu Leu Glu Ala Pro Asp Pro Ser Leu Phe Ala Val Ser Arg Tyr 
    610                 615                 620                 


Ala Gly Glu Val Arg Thr Ala Val Pro Ile Pro Ala Asp Leu Pro Pro 
625                 630                 635                 640 


Gln Lys Leu Val Ile Val Val Lys Asp Ser Gly Ser Pro Pro Leu Ser 
                645                 650                 655     


Thr Ser Val Thr Leu Leu Val Ser Leu Glu Glu Asp Thr His Pro Val 
            660                 665                 670         


Val Pro Asp Leu Arg Glu Ser Ser Ala Pro Arg Glu Gly Glu Ser Arg 
        675                 680                 685             


Leu Thr Leu Tyr Leu Ala Val Ser Leu Val Ala Ile Cys Phe Val Ser 
    690                 695                 700                 


Phe Gly Ser Phe Val Ala Leu Leu Ser Lys Cys Leu Arg Gly Ala Ala 
705                 710                 715                 720 


Cys Gly Val Thr Cys Phe Pro Ala Gly Thr Cys Ala Cys Leu Thr Arg 
                725                 730                 735     


Ser Arg Arg Arg Glu Gly Leu Pro Pro Ser Asn Gly Ile Leu Arg Ile 
            740                 745                 750         


Gln Leu Gly Ser Asp Asp Pro Ile Lys Phe Val Asp Val Gly Gly His 
        755                 760                 765             


Ser His Gly Cys Thr Pro Leu Ala Ser Ala Pro Thr Arg Ser Asp Ser 
    770                 775                 780                 


Phe Met Met Val Lys Ser Pro Ser Ala Pro Met Ala Gly Glu Pro Val 
785                 790                 795                 800 


Arg Pro Ser Cys Pro Pro Ser Asp Leu Leu Tyr Gly Leu Glu Gln Ala 
                805                 810                 815     


Pro Pro Asn Thr Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr 
            820                 825                 830         


Ser Gly Ser Gln Asn Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln 
        835                 840                 845             


Phe Asp Thr Glu Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser Glu 
    850                 855                 860                 


Ala Ala Asp Gly Ser Ser Thr Leu Gly Gly Gly Ala Gly Thr Met Gly 
865                 870                 875                 880 


Leu Ser Ala Arg Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro Asp 
                885                 890                 895     


Tyr Arg Gln Asn Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn 
            900                 905                 910         


Ala Ala Gly Lys Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn 
        915                 920                 925             


Lys Lys Lys Ser Gly Lys Lys Glu Lys Lys 
    930                 935             


<210>  5343
<211>  944
<212>  PRT
<213>  Homo sapiens

<400>  5343

Met Gly Pro Lys Thr Leu Pro Gln Leu Ala Gly Lys Trp Gln Val Leu 
1               5                   10                  15      


Cys Met Leu Ser Leu Cys Cys Trp Gly Trp Val Ser Gly Gln Leu Arg 
            20                  25                  30          


Tyr Ser Val Val Glu Glu Ser Glu Pro Gly Thr Leu Val Gly Asn Val 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Lys Met Thr Asp Leu Leu Ser Arg Arg Leu 
    50                  55                  60                  


Gln Leu Gly Ser Glu Glu Asn Gly Arg Tyr Phe Ser Leu Ser Leu Met 
65                  70                  75                  80  


Ser Gly Ala Leu Ala Val Asn Gln Lys Ile Asp Arg Glu Ser Leu Cys 
                85                  90                  95      


Gly Ala Ser Thr Ser Cys Leu Leu Pro Val Gln Val Val Thr Glu His 
            100                 105                 110         


Pro Leu Glu Leu Ile Arg Val Glu Val Glu Ile Leu Asp Leu Asn Asp 
        115                 120                 125             


Asn Ser Pro Ser Phe Ala Thr Pro Glu Arg Glu Met Arg Ile Ser Glu 
    130                 135                 140                 


Ser Ala Ala Ser Gly Ala Arg Phe Pro Leu Asp Ser Ala Gln Asp Pro 
145                 150                 155                 160 


Asp Val Gly Thr Asn Thr Val Ser Phe Tyr Thr Leu Ser Pro Asn Ser 
                165                 170                 175     


His Phe Ser Leu Asn Val Lys Thr Leu Lys Asp Gly Lys Pro Phe Pro 
            180                 185                 190         


Glu Leu Val Leu Glu Gln Gln Leu Asp Arg Glu Ala Gln Ala Arg His 
        195                 200                 205             


Gln Leu Val Leu Thr Ala Val Asp Gly Gly Thr Pro Ala Arg Ser Gly 
    210                 215                 220                 


Thr Thr Leu Ile Ser Val Ile Val Leu Asp Ile Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Thr Phe Gln Ser Ser Val Leu Arg Val Gly Ile Pro Glu Asn Ala Pro 
                245                 250                 255     


Ile Gly Thr Leu Leu Leu Arg Leu Asn Ala Thr Asp Pro Asp Glu Gly 
            260                 265                 270         


Thr Asn Gly Gln Leu Asp Tyr Ser Phe Gly Asp His Thr Ser Glu Ala 
        275                 280                 285             


Val Arg Asn Leu Phe Gly Leu Asp Pro Ser Ser Gly Ala Ile His Val 
    290                 295                 300                 


Leu Gly Pro Ile Asp Phe Glu Glu Ser Arg Phe Tyr Glu Ile His Ala 
305                 310                 315                 320 


Arg Ala Arg Asp Gln Gly Gln Pro Ala Met Glu Gly His Cys Val Ile 
                325                 330                 335     


Gln Val Asp Val Gly Asp Val Asn Asp Asn Ala Pro Glu Val Leu Leu 
            340                 345                 350         


Ala Ser Leu Ala Asn Pro Val Leu Glu Ser Thr Pro Val Gly Thr Val 
        355                 360                 365             


Val Gly Leu Phe Asn Val Arg Asp Arg Asp Ser Gly Arg Asn Gly Glu 
    370                 375                 380                 


Val Ser Leu Asp Ile Ser Pro Asp Leu Pro Phe Gln Ile Lys Pro Ser 
385                 390                 395                 400 


Glu Asn His Tyr Ser Leu Leu Thr Ser Gln Pro Leu Asp Arg Glu Ala 
                405                 410                 415     


Thr Ser His Tyr Ile Ile Glu Leu Leu Ala Ser Asp Ala Gly Ser Pro 
            420                 425                 430         


Ser Leu His Lys His Leu Thr Ile Arg Leu Asn Ile Ser Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Arg Phe Asn Gln Gln Leu Tyr Thr Ala Tyr Ile Leu 
    450                 455                 460                 


Glu Asn Arg Pro Pro Gly Ser Leu Leu Cys Thr Val Ala Ala Ser Asp 
465                 470                 475                 480 


Pro Asp Thr Gly Asp Asn Ala Arg Leu Thr Tyr Ser Ile Val Gly Asn 
                485                 490                 495     


Gln Val Gln Gly Ala Pro Ala Ser Ser Phe Val Tyr Val Asn Pro Glu 
            500                 505                 510         


Asp Gly Arg Ile Phe Ala Gln Arg Thr Phe Asp Tyr Glu Leu Leu Gln 
        515                 520                 525             


Met Leu Gln Ile Val Val Gly Val Arg Asp Ser Gly Ser Pro Pro Leu 
    530                 535                 540                 


His Ala Asn Thr Ser Leu His Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Val Leu His Pro Arg Pro Asp Trp Glu His Ser Ala Pro 
                565                 570                 575     


Gln Arg Leu Pro Arg Ser Ala Pro Pro Gly Ser Leu Val Thr Lys Val 
            580                 585                 590         


Thr Ala Val Asp Ala Asp Ala Gly His Asn Ala Trp Leu Ser Tyr Ser 
        595                 600                 605             


Leu Leu Pro Gln Ser Thr Ala Pro Gly Leu Phe Leu Val Ser Thr His 
    610                 615                 620                 


Thr Gly Glu Val Arg Thr Ala Arg Ala Leu Leu Glu Asp Asp Ser Asp 
625                 630                 635                 640 


Thr Gln Gln Val Val Val Leu Val Arg Asp Asn Gly Asp Pro Ser Leu 
                645                 650                 655     


Ser Ser Thr Ala Thr Val Leu Leu Val Leu Glu Asp Glu Asp Pro Glu 
            660                 665                 670         


Glu Met Pro Lys Ser Ser Asp Phe Leu Ile His Pro Pro Glu Arg Ser 
        675                 680                 685             


Asp Leu Thr Leu Tyr Leu Ile Val Ala Leu Ala Thr Val Ser Leu Leu 
    690                 695                 700                 


Ser Leu Val Thr Phe Thr Phe Leu Ser Ala Lys Cys Leu Gln Gly Asn 
705                 710                 715                 720 


Ala Asp Gly Asp Gly Gly Gly Gly Gln Cys Cys Arg Arg Gln Asp Ser 
                725                 730                 735     


Pro Ser Pro Asp Phe Tyr Lys Gln Ser Ser Pro Asn Leu Gln Val Ser 
            740                 745                 750         


Ser Asp Gly Thr Leu Lys Tyr Met Glu Val Thr Leu Arg Pro Thr Asp 
        755                 760                 765             


Ser Gln Ser His Cys Tyr Arg Thr Cys Phe Ser Pro Ala Ser Asp Gly 
    770                 775                 780                 


Ser Asp Phe Thr Phe Leu Arg Pro Leu Ser Val Gln Gln Pro Thr Ala 
785                 790                 795                 800 


Leu Ala Leu Glu Pro Asp Ala Ile Arg Ser Arg Ser Asn Thr Leu Arg 
                805                 810                 815     


Glu Arg Ser Gln Gln Ala Pro Pro Asn Thr Asp Trp Arg Phe Ser Gln 
            820                 825                 830         


Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly Asp Asp Thr Gly 
        835                 840                 845             


Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu Gln Ala Met Ile 
    850                 855                 860                 


Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser Thr Leu Gly Gly 
865                 870                 875                 880 


Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly Pro Gln Phe Thr 
                885                 890                 895     


Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr Ile Pro Gly Ser 
            900                 905                 910         


Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp Gly Lys Ala Pro 
        915                 920                 925             


Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys Lys Glu Lys Lys 
    930                 935                 940                 


<210>  5344
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  5344

Met Gly Glu Asn Asp Pro Pro Ala Val Glu Ala Pro Phe Ser Phe Arg 
1               5                   10                  15      


Ser Leu Phe Gly Leu Asp Asp Leu Lys Ile Ser Pro Val Ala Pro Asp 
            20                  25                  30          


Ala Asp Ala Val Ala Ala Gln Ile Leu Ser Leu Leu Pro Leu Lys Phe 
        35                  40                  45              


Phe Pro Ile Ile Val Ile Gly Ile Ile Ala Leu Ile Leu Ala Leu Ala 
    50                  55                  60                  


Ile Gly Leu Gly Ile His Phe Asp Cys Ser Gly Lys Tyr Arg Cys Arg 
65                  70                  75                  80  


Ser Ser Phe Lys Cys Ile Glu Leu Ile Ala Arg Cys Asp Gly Val Ser 
                85                  90                  95      


Asp Cys Lys Asp Gly Glu Asp Glu Tyr Arg Cys Val Arg Val Gly Gly 
            100                 105                 110         


Gln Asn Ala Val Leu Gln Val Phe Thr Ala Ala Ser Trp Lys Thr Met 
        115                 120                 125             


Cys Ser Asp Asp Trp Lys Gly His Tyr Ala Asn Val Ala Cys Ala Gln 
    130                 135                 140                 


Leu Gly Phe Pro Ser Tyr Val Ser Ser Asp Asn Leu Arg Val Ser Ser 
145                 150                 155                 160 


Leu Glu Gly Gln Phe Arg Glu Glu Phe Val Ser Ile Asp His Leu Leu 
                165                 170                 175     


Pro Asp Asp Lys Val Thr Ala Leu His His Ser Val Tyr Val Arg Glu 
            180                 185                 190         


Gly Cys Ala Ser Gly His Val Val Thr Leu Gln Cys Thr Ala Cys Gly 
        195                 200                 205             


His Arg Arg Gly Tyr Ser Ser Arg Ile Val Gly Gly Asn Met Ser Leu 
    210                 215                 220                 


Leu Ser Gln Trp Pro Trp Gln Ala Ser Leu Gln Phe Gln Gly Tyr His 
225                 230                 235                 240 


Leu Cys Gly Gly Ser Val Ile Thr Pro Leu Trp Ile Ile Thr Ala Ala 
                245                 250                 255     


His Cys Val Tyr Asp Leu Tyr Leu Pro Lys Ser Trp Thr Ile Gln Val 
            260                 265                 270         


Gly Leu Val Ser Leu Leu Asp Asn Pro Ala Pro Ser His Leu Val Glu 
        275                 280                 285             


Lys Ile Val Tyr His Ser Lys Tyr Lys Pro Lys Arg Leu Gly Asn Asp 
    290                 295                 300                 


Ile Ala Leu Met Lys Leu Ala Gly Pro Leu Thr Phe Asn Gly Thr Ser 
305                 310                 315                 320 


Gly Ser Leu Cys Gly Ser Ala Ala Leu Pro Leu Phe Gln Glu Asp Leu 
                325                 330                 335     


Gln Leu Leu Ile Glu Ala Phe Leu 
            340                 


<210>  5345
<211>  934
<212>  PRT
<213>  Homo sapiens

<400>  5345

Met Val Pro Glu Ala Trp Arg Ser Gly Leu Val Ser Thr Gly Arg Val 
1               5                   10                  15      


Val Gly Val Leu Leu Leu Leu Gly Ala Leu Asn Lys Ala Ser Thr Val 
            20                  25                  30          


Ile His Tyr Glu Ile Pro Glu Glu Arg Glu Lys Gly Phe Ala Val Gly 
        35                  40                  45              


Asn Val Val Ala Asn Leu Gly Leu Asp Leu Gly Ser Leu Ser Ala Arg 
    50                  55                  60                  


Arg Phe Arg Val Val Ser Gly Ala Ser Arg Arg Phe Phe Glu Val Asn 
65                  70                  75                  80  


Arg Glu Thr Gly Glu Met Phe Val Asn Asp Arg Leu Asp Arg Glu Glu 
                85                  90                  95      


Leu Cys Gly Thr Leu Pro Ser Cys Thr Val Thr Leu Glu Leu Val Val 
            100                 105                 110         


Glu Asn Pro Leu Glu Leu Phe Ser Val Glu Val Val Ile Gln Asp Ile 
        115                 120                 125             


Asn Asp Asn Asn Pro Ala Phe Pro Thr Gln Glu Met Lys Leu Glu Ile 
    130                 135                 140                 


Ser Glu Ala Val Ala Pro Gly Thr Arg Phe Pro Leu Glu Ser Ala His 
145                 150                 155                 160 


Asp Pro Asp Val Gly Ser Asn Ser Leu Gln Thr Tyr Glu Leu Ser Arg 
                165                 170                 175     


Asn Glu Tyr Phe Ala Leu Arg Val Gln Thr Arg Glu Asp Ser Thr Lys 
            180                 185                 190         


Tyr Ala Glu Leu Val Leu Glu Arg Ala Leu Asp Arg Glu Arg Glu Pro 
        195                 200                 205             


Ser Leu Gln Leu Val Leu Thr Ala Leu Asp Gly Gly Thr Pro Ala Leu 
    210                 215                 220                 


Ser Ala Ser Leu Pro Ile His Ile Lys Val Leu Asp Ala Asn Asp Asn 
225                 230                 235                 240 


Ala Pro Val Phe Asn Gln Ser Leu Tyr Arg Ala Arg Val Leu Glu Asp 
                245                 250                 255     


Ala Pro Ser Gly Thr Arg Val Val Gln Val Leu Ala Thr Asp Leu Asp 
            260                 265                 270         


Glu Gly Pro Asn Gly Glu Ile Ile Tyr Ser Phe Gly Ser His Asn Arg 
        275                 280                 285             


Ala Gly Val Arg Gln Leu Phe Ala Leu Asp Leu Val Thr Gly Met Leu 
    290                 295                 300                 


Thr Ile Lys Gly Arg Leu Asp Phe Glu Asp Thr Lys Leu His Glu Ile 
305                 310                 315                 320 


Tyr Ile Gln Ala Lys Asp Lys Gly Ala Asn Pro Glu Gly Ala His Cys 
                325                 330                 335     


Lys Val Leu Val Glu Val Val Asp Val Asn Asp Asn Ala Pro Glu Ile 
            340                 345                 350         


Thr Val Thr Ser Val Tyr Ser Pro Val Pro Glu Asp Ala Pro Leu Gly 
        355                 360                 365             


Thr Val Ile Ala Leu Leu Ser Val Thr Asp Leu Asp Ala Gly Glu Asn 
    370                 375                 380                 


Gly Leu Val Thr Cys Glu Val Pro Pro Gly Leu Pro Phe Ser Leu Thr 
385                 390                 395                 400 


Ser Ser Leu Lys Asn Tyr Phe Thr Leu Lys Thr Ser Ala Asp Leu Asp 
                405                 410                 415     


Arg Glu Thr Val Pro Glu Tyr Asn Leu Ser Ile Thr Ala Arg Asp Ala 
            420                 425                 430         


Gly Thr Pro Ser Leu Ser Ala Leu Thr Ile Val Arg Val Gln Val Ser 
        435                 440                 445             


Asp Ile Asn Asp Asn Pro Pro Gln Ser Ser Gln Ser Ser Tyr Asp Val 
    450                 455                 460                 


Tyr Ile Glu Glu Asn Asn Leu Pro Gly Ala Pro Ile Leu Asn Leu Ser 
465                 470                 475                 480 


Val Trp Asp Pro Asp Ala Pro Gln Asn Ala Arg Leu Ser Phe Phe Leu 
                485                 490                 495     


Leu Glu Gln Gly Ala Glu Thr Gly Leu Val Gly Arg Tyr Phe Thr Ile 
            500                 505                 510         


Asn Arg Asp Asn Gly Ile Val Ser Ser Leu Val Pro Leu Asp Tyr Glu 
        515                 520                 525             


Asp Arg Arg Glu Phe Glu Leu Thr Ala His Ile Ser Asp Gly Gly Thr 
    530                 535                 540                 


Pro Val Leu Ala Thr Asn Ile Ser Val Asn Ile Phe Val Thr Asp Arg 
545                 550                 555                 560 


Asn Asp Asn Ala Pro Gln Val Leu Tyr Pro Arg Pro Gly Gly Ser Ser 
                565                 570                 575     


Val Glu Met Leu Pro Arg Gly Thr Ser Ala Gly His Leu Val Ser Arg 
            580                 585                 590         


Val Val Gly Trp Asp Ala Asp Ala Gly His Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Ser Leu Leu Gly Ser Pro Asn Gln Ser Leu Phe Ala Ile Gly Leu His 
    610                 615                 620                 


Thr Gly Gln Ile Ser Thr Ala Arg Pro Val Gln Asp Thr Asp Ser Pro 
625                 630                 635                 640 


Arg Gln Thr Leu Thr Val Leu Ile Lys Asp Asn Gly Glu Pro Ser Leu 
                645                 650                 655     


Ser Thr Thr Ala Thr Leu Thr Val Ser Val Thr Glu Asp Ser Pro Glu 
            660                 665                 670         


Ala Arg Ala Glu Phe Pro Ser Gly Ser Ala Pro Arg Glu Gln Lys Lys 
        675                 680                 685             


Asn Leu Thr Phe Tyr Leu Leu Leu Ser Leu Ile Leu Val Ser Val Gly 
    690                 695                 700                 


Phe Val Val Thr Val Phe Gly Val Ile Ile Phe Lys Val Tyr Lys Trp 
705                 710                 715                 720 


Lys Gln Ser Arg Asp Leu Tyr Arg Ala Pro Val Ser Ser Leu Tyr Arg 
                725                 730                 735     


Thr Pro Gly Pro Ser Leu His Ala Asp Ala Val Arg Gly Gly Leu Met 
            740                 745                 750         


Ser Pro His Leu Tyr His Gln Val Tyr Leu Thr Thr Asp Ser Arg Arg 
        755                 760                 765             


Ser Asp Pro Leu Leu Lys Lys Pro Gly Ala Ala Ser Pro Leu Ala Ser 
    770                 775                 780                 


Arg Gln Asn Thr Leu Arg Ser Cys Asp Pro Val Phe Tyr Arg Gln Val 
785                 790                 795                 800 


Leu Gly Ala Glu Ser Ala Pro Pro Gly Gln Gln Ala Pro Pro Asn Thr 
                805                 810                 815     


Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln 
            820                 825                 830         


Asn Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu 
        835                 840                 845             


Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly 
    850                 855                 860                 


Ser Ser Thr Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg 
865                 870                 875                 880 


Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn 
                885                 890                 895     


Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys 
            900                 905                 910         


Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser 
        915                 920                 925             


Gly Lys Lys Glu Lys Lys 
    930                 


<210>  5346
<211>  938
<212>  PRT
<213>  Homo sapiens

<400>  5346

Met Leu Arg Lys Val Arg Ser Trp Thr Glu Ile Trp Arg Trp Ala Thr 
1               5                   10                  15      


Leu Leu Phe Leu Phe Tyr His Leu Gly Tyr Val Cys Gly Gln Ile Arg 
            20                  25                  30          


Tyr Pro Val Pro Glu Glu Ser Gln Glu Gly Thr Phe Val Gly Asn Val 
        35                  40                  45              


Ala Gln Asp Phe Leu Leu Asp Thr Asp Ser Leu Ser Ala Arg Arg Leu 
    50                  55                  60                  


Gln Val Ala Gly Glu Val Asn Gln Arg His Phe Arg Val Asp Leu Asp 
65                  70                  75                  80  


Ser Gly Ala Leu Leu Ile Lys Asn Pro Ile Asp Arg Glu Ala Leu Cys 
                85                  90                  95      


Gly Leu Ser Ala Ser Cys Ile Val Pro Leu Glu Phe Val Thr Glu Gly 
            100                 105                 110         


Pro Leu Glu Met Tyr Arg Ala Glu Val Glu Ile Val Asp Val Asn Asp 
        115                 120                 125             


His Ala Pro Arg Phe Pro Arg Gln Gln Leu Asp Leu Glu Ile Gly Glu 
    130                 135                 140                 


Ala Ala Pro Pro Gly Gln Arg Phe Pro Leu Glu Lys Ala Gln Asp Ala 
145                 150                 155                 160 


Asp Val Gly Ser Asn Ser Ile Ser Ser Tyr Arg Leu Ser Ser Asn Glu 
                165                 170                 175     


His Phe Ala Leu Asp Val Lys Lys Arg Ser Asp Gly Ser Leu Val Pro 
            180                 185                 190         


Glu Leu Leu Leu Glu Lys Pro Leu Asp Arg Glu Lys Gln Ser Asp Tyr 
        195                 200                 205             


Arg Leu Val Leu Thr Ala Val Asp Gly Gly Asn Pro Pro Arg Ser Gly 
    210                 215                 220                 


Thr Ala Glu Leu Arg Val Ser Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Ala Phe Gln Gln Ser Ser Tyr Arg Ile Ser Val Leu Glu Ser Ala Pro 
                245                 250                 255     


Ala Gly Met Val Leu Ile Gln Leu Asn Ala Ser Asp Pro Asp Leu Gly 
            260                 265                 270         


Pro Ser Gly Asn Val Thr Phe Tyr Phe Ser Gly His Thr Pro Asp Arg 
        275                 280                 285             


Val Arg Asn Leu Phe Ser Leu His Pro Thr Thr Gly Lys Leu Thr Leu 
    290                 295                 300                 


Leu Gly Pro Leu Asp Phe Glu Ser Glu Asn Tyr Tyr Glu Phe Asp Val 
305                 310                 315                 320 


Arg Ala Arg Asp Gly Gly Ser Pro Ala Met Glu Gln His Cys Ser Leu 
                325                 330                 335     


Arg Val Asp Leu Leu Asp Val Asn Asp Asn Ala Pro Tyr Ile Thr Val 
            340                 345                 350         


Thr Ser Glu Leu Gly Thr Leu Pro Glu Ser Ala Glu Pro Gly Thr Val 
        355                 360                 365             


Val Ala Leu Ile Ser Val Gln Asp Pro Asp Ser Gly Ser Asn Gly Asp 
    370                 375                 380                 


Val Ser Leu Arg Ile Pro Asp His Leu Pro Phe Ala Leu Lys Ser Ala 
385                 390                 395                 400 


Phe Arg Asn Gln Phe Ser Leu Val Thr Ala Gly Pro Leu Asp Arg Glu 
                405                 410                 415     


Ala Lys Ser Ser Tyr Asp Ile Met Val Thr Ala Ser Asp Ala Gly Asn 
            420                 425                 430         


Pro Pro Leu Ser Thr His Arg Thr Ile Phe Leu Asn Ile Ser Asp Val 
        435                 440                 445             


Asn Asp Asn Pro Pro Ser Phe Phe Gln Arg Ser His Glu Val Phe Val 
    450                 455                 460                 


Pro Glu Asn Asn Arg Pro Gly Asp Leu Leu Cys Ser Leu Ala Ala Ser 
465                 470                 475                 480 


Asp Pro Asp Ser Gly Leu Asn Ala Leu Ile Ser Tyr Ser Leu Leu Glu 
                485                 490                 495     


Pro Arg Asn Arg Asp Val Ser Ala Ser Ser Phe Ile Ser Leu Asn Pro 
            500                 505                 510         


Gln Thr Gly Ala Val His Ala Thr Arg Ser Phe Asp Tyr Glu Gln Thr 
        515                 520                 525             


Gln Thr Leu Gln Phe Glu Val Gln Ala Arg Asp Arg Gly Asn Pro Pro 
    530                 535                 540                 


Leu Ser Ser Thr Val Thr Val Arg Leu Phe Val Leu Asp Leu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Val Leu Arg Pro Arg Ala Arg Pro Gly Ser Leu Cys 
                565                 570                 575     


Pro Gln Ala Leu Pro Pro Ser Val Gly Ala Gly His Leu Ile Thr Lys 
            580                 585                 590         


Val Thr Ala Val Asp Leu Asp Ser Gly Tyr Asn Ala Trp Val Ser Tyr 
        595                 600                 605             


Gln Leu Leu Glu Ala Pro Asp Pro Ser Leu Phe Ala Val Ser Arg Tyr 
    610                 615                 620                 


Ala Gly Glu Val Arg Thr Ala Val Pro Ile Pro Ala Asp Leu Pro Pro 
625                 630                 635                 640 


Gln Lys Leu Val Ile Val Val Lys Asp Ser Gly Ser Pro Pro Leu Ser 
                645                 650                 655     


Thr Ser Val Thr Leu Leu Val Ser Leu Glu Glu Asp Thr His Pro Val 
            660                 665                 670         


Val Pro Asp Leu Arg Glu Ser Ser Ala Pro Arg Glu Gly Glu Ser Arg 
        675                 680                 685             


Leu Thr Leu Tyr Leu Ala Val Ser Leu Val Ala Ile Cys Phe Val Ser 
    690                 695                 700                 


Phe Gly Ser Phe Val Ala Leu Leu Ser Lys Cys Leu Arg Gly Ala Ala 
705                 710                 715                 720 


Cys Gly Val Thr Cys Phe Pro Ala Gly Thr Cys Ala Cys Leu Thr Arg 
                725                 730                 735     


Ser Arg Arg Arg Glu Gly Leu Pro Pro Ser Asn Gly Ile Leu Arg Ile 
            740                 745                 750         


Gln Leu Gly Ser Asp Asp Pro Ile Lys Phe Val Asp Val Gly Gly His 
        755                 760                 765             


Ser His Gly Cys Thr Pro Leu Ala Ser Ala Pro Thr Arg Ser Asp Ser 
    770                 775                 780                 


Phe Met Met Val Lys Ser Pro Ser Ala Pro Met Ala Gly Glu Pro Val 
785                 790                 795                 800 


Arg Pro Ser Cys Pro Pro Ser Asp Leu Leu Tyr Gly Leu Glu Gln Ala 
                805                 810                 815     


Pro Pro Asn Thr Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr 
            820                 825                 830         


Ser Gly Ser Gln Asn Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln 
        835                 840                 845             


Phe Asp Thr Glu Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser Glu 
    850                 855                 860                 


Ala Ala Asp Gly Ser Ser Thr Leu Gly Gly Gly Ala Gly Thr Met Gly 
865                 870                 875                 880 


Leu Ser Ala Arg Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro Asp 
                885                 890                 895     


Tyr Arg Gln Asn Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn 
            900                 905                 910         


Ala Ala Gly Lys Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn 
        915                 920                 925             


Lys Lys Lys Ser Gly Lys Lys Glu Lys Lys 
    930                 935             


<210>  5347
<211>  944
<212>  PRT
<213>  Homo sapiens

<400>  5347

Met Gly Pro Lys Thr Leu Pro Gln Leu Ala Gly Lys Trp Gln Val Leu 
1               5                   10                  15      


Cys Met Leu Ser Leu Cys Cys Trp Gly Trp Val Ser Gly Gln Leu Arg 
            20                  25                  30          


Tyr Ser Val Val Glu Glu Ser Glu Pro Gly Thr Leu Val Gly Asn Val 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Lys Met Thr Asp Leu Leu Ser Arg Arg Leu 
    50                  55                  60                  


Gln Leu Gly Ser Glu Glu Asn Gly Arg Tyr Phe Ser Leu Ser Leu Met 
65                  70                  75                  80  


Ser Gly Ala Leu Ala Val Asn Gln Lys Ile Asp Arg Glu Ser Leu Cys 
                85                  90                  95      


Gly Ala Ser Thr Ser Cys Leu Leu Pro Val Gln Val Val Thr Glu His 
            100                 105                 110         


Pro Leu Glu Leu Ile Arg Val Glu Val Glu Ile Leu Asp Leu Asn Asp 
        115                 120                 125             


Asn Ser Pro Ser Phe Ala Thr Pro Glu Arg Glu Met Arg Ile Ser Glu 
    130                 135                 140                 


Ser Ala Ala Ser Gly Ala Arg Phe Pro Leu Asp Ser Ala Gln Asp Pro 
145                 150                 155                 160 


Asp Val Gly Thr Asn Thr Val Ser Phe Tyr Thr Leu Ser Pro Asn Ser 
                165                 170                 175     


His Phe Ser Leu Asn Val Lys Thr Leu Lys Asp Gly Lys Pro Phe Pro 
            180                 185                 190         


Glu Leu Val Leu Glu Gln Gln Leu Asp Arg Glu Ala Gln Ala Arg His 
        195                 200                 205             


Gln Leu Val Leu Thr Ala Val Asp Gly Gly Thr Pro Ala Arg Ser Gly 
    210                 215                 220                 


Thr Thr Leu Ile Ser Val Ile Val Leu Asp Ile Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Thr Phe Gln Ser Ser Val Leu Arg Val Gly Ile Pro Glu Asn Ala Pro 
                245                 250                 255     


Ile Gly Thr Leu Leu Leu Arg Leu Asn Ala Thr Asp Pro Asp Glu Gly 
            260                 265                 270         


Thr Asn Gly Gln Leu Asp Tyr Ser Phe Gly Asp His Thr Ser Glu Ala 
        275                 280                 285             


Val Arg Asn Leu Phe Gly Leu Asp Pro Ser Ser Gly Ala Ile His Val 
    290                 295                 300                 


Leu Gly Pro Ile Asp Phe Glu Glu Ser Arg Phe Tyr Glu Ile His Ala 
305                 310                 315                 320 


Arg Ala Arg Asp Gln Gly Gln Pro Ala Met Glu Gly His Cys Val Ile 
                325                 330                 335     


Gln Val Asp Val Gly Asp Val Asn Asp Asn Ala Pro Glu Val Leu Leu 
            340                 345                 350         


Ala Ser Leu Ala Asn Pro Val Leu Glu Ser Thr Pro Val Gly Thr Val 
        355                 360                 365             


Val Gly Leu Phe Asn Val Arg Asp Arg Asp Ser Gly Arg Asn Gly Glu 
    370                 375                 380                 


Val Ser Leu Asp Ile Ser Pro Asp Leu Pro Phe Gln Ile Lys Pro Ser 
385                 390                 395                 400 


Glu Asn His Tyr Ser Leu Leu Thr Ser Gln Pro Leu Asp Arg Glu Ala 
                405                 410                 415     


Thr Ser His Tyr Ile Ile Glu Leu Leu Ala Ser Asp Ala Gly Ser Pro 
            420                 425                 430         


Ser Leu His Lys His Leu Thr Ile Arg Leu Asn Ile Ser Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Arg Phe Asn Gln Gln Leu Tyr Thr Ala Tyr Ile Leu 
    450                 455                 460                 


Glu Asn Arg Pro Pro Gly Ser Leu Leu Cys Thr Val Ala Ala Ser Asp 
465                 470                 475                 480 


Pro Asp Thr Gly Asp Asn Ala Arg Leu Thr Tyr Ser Ile Val Gly Asn 
                485                 490                 495     


Gln Val Gln Gly Ala Pro Ala Ser Ser Phe Val Tyr Val Asn Pro Glu 
            500                 505                 510         


Asp Gly Arg Ile Phe Ala Gln Arg Thr Phe Asp Tyr Glu Leu Leu Gln 
        515                 520                 525             


Met Leu Gln Ile Val Val Gly Val Arg Asp Ser Gly Ser Pro Pro Leu 
    530                 535                 540                 


His Ala Asn Thr Ser Leu His Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Val Leu His Pro Arg Pro Asp Trp Glu His Ser Ala Pro 
                565                 570                 575     


Gln Arg Leu Pro Arg Ser Ala Pro Pro Gly Ser Leu Val Thr Lys Val 
            580                 585                 590         


Thr Ala Val Asp Ala Asp Ala Gly His Asn Ala Trp Leu Ser Tyr Ser 
        595                 600                 605             


Leu Leu Pro Gln Ser Thr Ala Pro Gly Leu Phe Leu Val Ser Thr His 
    610                 615                 620                 


Thr Gly Glu Val Arg Thr Ala Arg Ala Leu Leu Glu Asp Asp Ser Asp 
625                 630                 635                 640 


Thr Gln Gln Val Val Val Leu Val Arg Asp Asn Gly Asp Pro Ser Leu 
                645                 650                 655     


Ser Ser Thr Ala Thr Val Leu Leu Val Leu Glu Asp Glu Asp Pro Glu 
            660                 665                 670         


Glu Met Pro Lys Ser Ser Asp Phe Leu Ile His Pro Pro Glu Arg Ser 
        675                 680                 685             


Asp Leu Thr Leu Tyr Leu Ile Val Ala Leu Ala Thr Val Ser Leu Leu 
    690                 695                 700                 


Ser Leu Val Thr Phe Thr Phe Leu Ser Ala Lys Cys Leu Gln Gly Asn 
705                 710                 715                 720 


Ala Asp Gly Asp Gly Gly Gly Gly Gln Cys Cys Arg Arg Gln Asp Ser 
                725                 730                 735     


Pro Ser Pro Asp Phe Tyr Lys Gln Ser Ser Pro Asn Leu Gln Val Ser 
            740                 745                 750         


Ser Asp Gly Thr Leu Lys Tyr Met Glu Val Thr Leu Arg Pro Thr Asp 
        755                 760                 765             


Ser Gln Ser His Cys Tyr Arg Thr Cys Phe Ser Pro Ala Ser Asp Gly 
    770                 775                 780                 


Ser Asp Phe Thr Phe Leu Arg Pro Leu Ser Val Gln Gln Pro Thr Ala 
785                 790                 795                 800 


Leu Ala Leu Glu Pro Asp Ala Ile Arg Ser Arg Ser Asn Thr Leu Arg 
                805                 810                 815     


Glu Arg Ser Gln Gln Ala Pro Pro Asn Thr Asp Trp Arg Phe Ser Gln 
            820                 825                 830         


Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly Asp Asp Thr Gly 
        835                 840                 845             


Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu Gln Ala Met Ile 
    850                 855                 860                 


Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser Thr Leu Gly Gly 
865                 870                 875                 880 


Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly Pro Gln Phe Thr 
                885                 890                 895     


Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr Ile Pro Gly Ser 
            900                 905                 910         


Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp Gly Lys Ala Pro 
        915                 920                 925             


Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys Lys Glu Lys Lys 
    930                 935                 940                 


<210>  5348
<211>  934
<212>  PRT
<213>  Homo sapiens

<400>  5348

Met Val Pro Glu Ala Trp Arg Ser Gly Leu Val Ser Thr Gly Arg Val 
1               5                   10                  15      


Val Gly Val Leu Leu Leu Leu Gly Ala Leu Asn Lys Ala Ser Thr Val 
            20                  25                  30          


Ile His Tyr Glu Ile Pro Glu Glu Arg Glu Lys Gly Phe Ala Val Gly 
        35                  40                  45              


Asn Val Val Ala Asn Leu Gly Leu Asp Leu Gly Ser Leu Ser Ala Arg 
    50                  55                  60                  


Arg Phe Arg Val Val Ser Gly Ala Ser Arg Arg Phe Phe Glu Val Asn 
65                  70                  75                  80  


Arg Glu Thr Gly Glu Met Phe Val Asn Asp Arg Leu Asp Arg Glu Glu 
                85                  90                  95      


Leu Cys Gly Thr Leu Pro Ser Cys Thr Val Thr Leu Glu Leu Val Val 
            100                 105                 110         


Glu Asn Pro Leu Glu Leu Phe Ser Val Glu Val Val Ile Gln Asp Ile 
        115                 120                 125             


Asn Asp Asn Asn Pro Ala Phe Pro Thr Gln Glu Met Lys Leu Glu Ile 
    130                 135                 140                 


Ser Glu Ala Val Ala Pro Gly Thr Arg Phe Pro Leu Glu Ser Ala His 
145                 150                 155                 160 


Asp Pro Asp Val Gly Ser Asn Ser Leu Gln Thr Tyr Glu Leu Ser Arg 
                165                 170                 175     


Asn Glu Tyr Phe Ala Leu Arg Val Gln Thr Arg Glu Asp Ser Thr Lys 
            180                 185                 190         


Tyr Ala Glu Leu Val Leu Glu Arg Ala Leu Asp Arg Glu Arg Glu Pro 
        195                 200                 205             


Ser Leu Gln Leu Val Leu Thr Ala Leu Asp Gly Gly Thr Pro Ala Leu 
    210                 215                 220                 


Ser Ala Ser Leu Pro Ile His Ile Lys Val Leu Asp Ala Asn Asp Asn 
225                 230                 235                 240 


Ala Pro Val Phe Asn Gln Ser Leu Tyr Arg Ala Arg Val Leu Glu Asp 
                245                 250                 255     


Ala Pro Ser Gly Thr Arg Val Val Gln Val Leu Ala Thr Asp Leu Asp 
            260                 265                 270         


Glu Gly Pro Asn Gly Glu Ile Ile Tyr Ser Phe Gly Ser His Asn Arg 
        275                 280                 285             


Ala Gly Val Arg Gln Leu Phe Ala Leu Asp Leu Val Thr Gly Met Leu 
    290                 295                 300                 


Thr Ile Lys Gly Arg Leu Asp Phe Glu Asp Thr Lys Leu His Glu Ile 
305                 310                 315                 320 


Tyr Ile Gln Ala Lys Asp Lys Gly Ala Asn Pro Glu Gly Ala His Cys 
                325                 330                 335     


Lys Val Leu Val Glu Val Val Asp Val Asn Asp Asn Ala Pro Glu Ile 
            340                 345                 350         


Thr Val Thr Ser Val Tyr Ser Pro Val Pro Glu Asp Ala Pro Leu Gly 
        355                 360                 365             


Thr Val Ile Ala Leu Leu Ser Val Thr Asp Leu Asp Ala Gly Glu Asn 
    370                 375                 380                 


Gly Leu Val Thr Cys Glu Val Pro Pro Gly Leu Pro Phe Ser Leu Thr 
385                 390                 395                 400 


Ser Ser Leu Lys Asn Tyr Phe Thr Leu Lys Thr Ser Ala Asp Leu Asp 
                405                 410                 415     


Arg Glu Thr Val Pro Glu Tyr Asn Leu Ser Ile Thr Ala Arg Asp Ala 
            420                 425                 430         


Gly Thr Pro Ser Leu Ser Ala Leu Thr Ile Val Arg Val Gln Val Ser 
        435                 440                 445             


Asp Ile Asn Asp Asn Pro Pro Gln Ser Ser Gln Ser Ser Tyr Asp Val 
    450                 455                 460                 


Tyr Ile Glu Glu Asn Asn Leu Pro Gly Ala Pro Ile Leu Asn Leu Ser 
465                 470                 475                 480 


Val Trp Asp Pro Asp Ala Pro Gln Asn Ala Arg Leu Ser Phe Phe Leu 
                485                 490                 495     


Leu Glu Gln Gly Ala Glu Thr Gly Leu Val Gly Arg Tyr Phe Thr Ile 
            500                 505                 510         


Asn Arg Asp Asn Gly Ile Val Ser Ser Leu Val Pro Leu Asp Tyr Glu 
        515                 520                 525             


Asp Arg Arg Glu Phe Glu Leu Thr Ala His Ile Ser Asp Gly Gly Thr 
    530                 535                 540                 


Pro Val Leu Ala Thr Asn Ile Ser Val Asn Ile Phe Val Thr Asp Arg 
545                 550                 555                 560 


Asn Asp Asn Ala Pro Gln Val Leu Tyr Pro Arg Pro Gly Gly Ser Ser 
                565                 570                 575     


Val Glu Met Leu Pro Arg Gly Thr Ser Ala Gly His Leu Val Ser Arg 
            580                 585                 590         


Val Val Gly Trp Asp Ala Asp Ala Gly His Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Ser Leu Leu Gly Ser Pro Asn Gln Ser Leu Phe Ala Ile Gly Leu His 
    610                 615                 620                 


Thr Gly Gln Ile Ser Thr Ala Arg Pro Val Gln Asp Thr Asp Ser Pro 
625                 630                 635                 640 


Arg Gln Thr Leu Thr Val Leu Ile Lys Asp Asn Gly Glu Pro Ser Leu 
                645                 650                 655     


Ser Thr Thr Ala Thr Leu Thr Val Ser Val Thr Glu Asp Ser Pro Glu 
            660                 665                 670         


Ala Arg Ala Glu Phe Pro Ser Gly Ser Ala Pro Arg Glu Gln Lys Lys 
        675                 680                 685             


Asn Leu Thr Phe Tyr Leu Leu Leu Ser Leu Ile Leu Val Ser Val Gly 
    690                 695                 700                 


Phe Val Val Thr Val Phe Gly Val Ile Ile Phe Lys Val Tyr Lys Trp 
705                 710                 715                 720 


Lys Gln Ser Arg Asp Leu Tyr Arg Ala Pro Val Ser Ser Leu Tyr Arg 
                725                 730                 735     


Thr Pro Gly Pro Ser Leu His Ala Asp Ala Val Arg Gly Gly Leu Met 
            740                 745                 750         


Ser Pro His Leu Tyr His Gln Val Tyr Leu Thr Thr Asp Ser Arg Arg 
        755                 760                 765             


Ser Asp Pro Leu Leu Lys Lys Pro Gly Ala Ala Ser Pro Leu Ala Ser 
    770                 775                 780                 


Arg Gln Asn Thr Leu Arg Ser Cys Asp Pro Val Phe Tyr Arg Gln Val 
785                 790                 795                 800 


Leu Gly Ala Glu Ser Ala Pro Pro Gly Gln Gln Ala Pro Pro Asn Thr 
                805                 810                 815     


Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln 
            820                 825                 830         


Asn Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu 
        835                 840                 845             


Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly 
    850                 855                 860                 


Ser Ser Thr Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg 
865                 870                 875                 880 


Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn 
                885                 890                 895     


Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys 
            900                 905                 910         


Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser 
        915                 920                 925             


Gly Lys Lys Glu Lys Lys 
    930                 


<210>  5349
<211>  938
<212>  PRT
<213>  Homo sapiens

<400>  5349

Met Leu Arg Lys Val Arg Ser Trp Thr Glu Ile Trp Arg Trp Ala Thr 
1               5                   10                  15      


Leu Leu Phe Leu Phe Tyr His Leu Gly Tyr Val Cys Gly Gln Ile Arg 
            20                  25                  30          


Tyr Pro Val Pro Glu Glu Ser Gln Glu Gly Thr Phe Val Gly Asn Val 
        35                  40                  45              


Ala Gln Asp Phe Leu Leu Asp Thr Asp Ser Leu Ser Ala Arg Arg Leu 
    50                  55                  60                  


Gln Val Ala Gly Glu Val Asn Gln Arg His Phe Arg Val Asp Leu Asp 
65                  70                  75                  80  


Ser Gly Ala Leu Leu Ile Lys Asn Pro Ile Asp Arg Glu Ala Leu Cys 
                85                  90                  95      


Gly Leu Ser Ala Ser Cys Ile Val Pro Leu Glu Phe Val Thr Glu Gly 
            100                 105                 110         


Pro Leu Glu Met Tyr Arg Ala Glu Val Glu Ile Val Asp Val Asn Asp 
        115                 120                 125             


His Ala Pro Arg Phe Pro Arg Gln Gln Leu Asp Leu Glu Ile Gly Glu 
    130                 135                 140                 


Ala Ala Pro Pro Gly Gln Arg Phe Pro Leu Glu Lys Ala Gln Asp Ala 
145                 150                 155                 160 


Asp Val Gly Ser Asn Ser Ile Ser Ser Tyr Arg Leu Ser Ser Asn Glu 
                165                 170                 175     


His Phe Ala Leu Asp Val Lys Lys Arg Ser Asp Gly Ser Leu Val Pro 
            180                 185                 190         


Glu Leu Leu Leu Glu Lys Pro Leu Asp Arg Glu Lys Gln Ser Asp Tyr 
        195                 200                 205             


Arg Leu Val Leu Thr Ala Val Asp Gly Gly Asn Pro Pro Arg Ser Gly 
    210                 215                 220                 


Thr Ala Glu Leu Arg Val Ser Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Ala Phe Gln Gln Ser Ser Tyr Arg Ile Ser Val Leu Glu Ser Ala Pro 
                245                 250                 255     


Ala Gly Met Val Leu Ile Gln Leu Asn Ala Ser Asp Pro Asp Leu Gly 
            260                 265                 270         


Pro Ser Gly Asn Val Thr Phe Tyr Phe Ser Gly His Thr Pro Asp Arg 
        275                 280                 285             


Val Arg Asn Leu Phe Ser Leu His Pro Thr Thr Gly Lys Leu Thr Leu 
    290                 295                 300                 


Leu Gly Pro Leu Asp Phe Glu Ser Glu Asn Tyr Tyr Glu Phe Asp Val 
305                 310                 315                 320 


Arg Ala Arg Asp Gly Gly Ser Pro Ala Met Glu Gln His Cys Ser Leu 
                325                 330                 335     


Arg Val Asp Leu Leu Asp Val Asn Asp Asn Ala Pro Tyr Ile Thr Val 
            340                 345                 350         


Thr Ser Glu Leu Gly Thr Leu Pro Glu Ser Ala Glu Pro Gly Thr Val 
        355                 360                 365             


Val Ala Leu Ile Ser Val Gln Asp Pro Asp Ser Gly Ser Asn Gly Asp 
    370                 375                 380                 


Val Ser Leu Arg Ile Pro Asp His Leu Pro Phe Ala Leu Lys Ser Ala 
385                 390                 395                 400 


Phe Arg Asn Gln Phe Ser Leu Val Thr Ala Gly Pro Leu Asp Arg Glu 
                405                 410                 415     


Ala Lys Ser Ser Tyr Asp Ile Met Val Thr Ala Ser Asp Ala Gly Asn 
            420                 425                 430         


Pro Pro Leu Ser Thr His Arg Thr Ile Phe Leu Asn Ile Ser Asp Val 
        435                 440                 445             


Asn Asp Asn Pro Pro Ser Phe Phe Gln Arg Ser His Glu Val Phe Val 
    450                 455                 460                 


Pro Glu Asn Asn Arg Pro Gly Asp Leu Leu Cys Ser Leu Ala Ala Ser 
465                 470                 475                 480 


Asp Pro Asp Ser Gly Leu Asn Ala Leu Ile Ser Tyr Ser Leu Leu Glu 
                485                 490                 495     


Pro Arg Asn Arg Asp Val Ser Ala Ser Ser Phe Ile Ser Leu Asn Pro 
            500                 505                 510         


Gln Thr Gly Ala Val His Ala Thr Arg Ser Phe Asp Tyr Glu Gln Thr 
        515                 520                 525             


Gln Thr Leu Gln Phe Glu Val Gln Ala Arg Asp Arg Gly Asn Pro Pro 
    530                 535                 540                 


Leu Ser Ser Thr Val Thr Val Arg Leu Phe Val Leu Asp Leu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Val Leu Arg Pro Arg Ala Arg Pro Gly Ser Leu Cys 
                565                 570                 575     


Pro Gln Ala Leu Pro Pro Ser Val Gly Ala Gly His Leu Ile Thr Lys 
            580                 585                 590         


Val Thr Ala Val Asp Leu Asp Ser Gly Tyr Asn Ala Trp Val Ser Tyr 
        595                 600                 605             


Gln Leu Leu Glu Ala Pro Asp Pro Ser Leu Phe Ala Val Ser Arg Tyr 
    610                 615                 620                 


Ala Gly Glu Val Arg Thr Ala Val Pro Ile Pro Ala Asp Leu Pro Pro 
625                 630                 635                 640 


Gln Lys Leu Val Ile Val Val Lys Asp Ser Gly Ser Pro Pro Leu Ser 
                645                 650                 655     


Thr Ser Val Thr Leu Leu Val Ser Leu Glu Glu Asp Thr His Pro Val 
            660                 665                 670         


Val Pro Asp Leu Arg Glu Ser Ser Ala Pro Arg Glu Gly Glu Ser Arg 
        675                 680                 685             


Leu Thr Leu Tyr Leu Ala Val Ser Leu Val Ala Ile Cys Phe Val Ser 
    690                 695                 700                 


Phe Gly Ser Phe Val Ala Leu Leu Ser Lys Cys Leu Arg Gly Ala Ala 
705                 710                 715                 720 


Cys Gly Val Thr Cys Phe Pro Ala Gly Thr Cys Ala Cys Leu Thr Arg 
                725                 730                 735     


Ser Arg Arg Arg Glu Gly Leu Pro Pro Ser Asn Gly Ile Leu Arg Ile 
            740                 745                 750         


Gln Leu Gly Ser Asp Asp Pro Ile Lys Phe Val Asp Val Gly Gly His 
        755                 760                 765             


Ser His Gly Cys Thr Pro Leu Ala Ser Ala Pro Thr Arg Ser Asp Ser 
    770                 775                 780                 


Phe Met Met Val Lys Ser Pro Ser Ala Pro Met Ala Gly Glu Pro Val 
785                 790                 795                 800 


Arg Pro Ser Cys Pro Pro Ser Asp Leu Leu Tyr Gly Leu Glu Gln Ala 
                805                 810                 815     


Pro Pro Asn Thr Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr 
            820                 825                 830         


Ser Gly Ser Gln Asn Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln 
        835                 840                 845             


Phe Asp Thr Glu Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser Glu 
    850                 855                 860                 


Ala Ala Asp Gly Ser Ser Thr Leu Gly Gly Gly Ala Gly Thr Met Gly 
865                 870                 875                 880 


Leu Ser Ala Arg Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro Asp 
                885                 890                 895     


Tyr Arg Gln Asn Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn 
            900                 905                 910         


Ala Ala Gly Lys Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn 
        915                 920                 925             


Lys Lys Lys Ser Gly Lys Lys Glu Lys Lys 
    930                 935             


<210>  5350
<211>  944
<212>  PRT
<213>  Homo sapiens

<400>  5350

Met Gly Pro Lys Thr Leu Pro Gln Leu Ala Gly Lys Trp Gln Val Leu 
1               5                   10                  15      


Cys Met Leu Ser Leu Cys Cys Trp Gly Trp Val Ser Gly Gln Leu Arg 
            20                  25                  30          


Tyr Ser Val Val Glu Glu Ser Glu Pro Gly Thr Leu Val Gly Asn Val 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Lys Met Thr Asp Leu Leu Ser Arg Arg Leu 
    50                  55                  60                  


Gln Leu Gly Ser Glu Glu Asn Gly Arg Tyr Phe Ser Leu Ser Leu Met 
65                  70                  75                  80  


Ser Gly Ala Leu Ala Val Asn Gln Lys Ile Asp Arg Glu Ser Leu Cys 
                85                  90                  95      


Gly Ala Ser Thr Ser Cys Leu Leu Pro Val Gln Val Val Thr Glu His 
            100                 105                 110         


Pro Leu Glu Leu Ile Arg Val Glu Val Glu Ile Leu Asp Leu Asn Asp 
        115                 120                 125             


Asn Ser Pro Ser Phe Ala Thr Pro Glu Arg Glu Met Arg Ile Ser Glu 
    130                 135                 140                 


Ser Ala Ala Ser Gly Ala Arg Phe Pro Leu Asp Ser Ala Gln Asp Pro 
145                 150                 155                 160 


Asp Val Gly Thr Asn Thr Val Ser Phe Tyr Thr Leu Ser Pro Asn Ser 
                165                 170                 175     


His Phe Ser Leu Asn Val Lys Thr Leu Lys Asp Gly Lys Pro Phe Pro 
            180                 185                 190         


Glu Leu Val Leu Glu Gln Gln Leu Asp Arg Glu Ala Gln Ala Arg His 
        195                 200                 205             


Gln Leu Val Leu Thr Ala Val Asp Gly Gly Thr Pro Ala Arg Ser Gly 
    210                 215                 220                 


Thr Thr Leu Ile Ser Val Ile Val Leu Asp Ile Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Thr Phe Gln Ser Ser Val Leu Arg Val Gly Ile Pro Glu Asn Ala Pro 
                245                 250                 255     


Ile Gly Thr Leu Leu Leu Arg Leu Asn Ala Thr Asp Pro Asp Glu Gly 
            260                 265                 270         


Thr Asn Gly Gln Leu Asp Tyr Ser Phe Gly Asp His Thr Ser Glu Ala 
        275                 280                 285             


Val Arg Asn Leu Phe Gly Leu Asp Pro Ser Ser Gly Ala Ile His Val 
    290                 295                 300                 


Leu Gly Pro Ile Asp Phe Glu Glu Ser Arg Phe Tyr Glu Ile His Ala 
305                 310                 315                 320 


Arg Ala Arg Asp Gln Gly Gln Pro Ala Met Glu Gly His Cys Val Ile 
                325                 330                 335     


Gln Val Asp Val Gly Asp Val Asn Asp Asn Ala Pro Glu Val Leu Leu 
            340                 345                 350         


Ala Ser Leu Ala Asn Pro Val Leu Glu Ser Thr Pro Val Gly Thr Val 
        355                 360                 365             


Val Gly Leu Phe Asn Val Arg Asp Arg Asp Ser Gly Arg Asn Gly Glu 
    370                 375                 380                 


Val Ser Leu Asp Ile Ser Pro Asp Leu Pro Phe Gln Ile Lys Pro Ser 
385                 390                 395                 400 


Glu Asn His Tyr Ser Leu Leu Thr Ser Gln Pro Leu Asp Arg Glu Ala 
                405                 410                 415     


Thr Ser His Tyr Ile Ile Glu Leu Leu Ala Ser Asp Ala Gly Ser Pro 
            420                 425                 430         


Ser Leu His Lys His Leu Thr Ile Arg Leu Asn Ile Ser Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Arg Phe Asn Gln Gln Leu Tyr Thr Ala Tyr Ile Leu 
    450                 455                 460                 


Glu Asn Arg Pro Pro Gly Ser Leu Leu Cys Thr Val Ala Ala Ser Asp 
465                 470                 475                 480 


Pro Asp Thr Gly Asp Asn Ala Arg Leu Thr Tyr Ser Ile Val Gly Asn 
                485                 490                 495     


Gln Val Gln Gly Ala Pro Ala Ser Ser Phe Val Tyr Val Asn Pro Glu 
            500                 505                 510         


Asp Gly Arg Ile Phe Ala Gln Arg Thr Phe Asp Tyr Glu Leu Leu Gln 
        515                 520                 525             


Met Leu Gln Ile Val Val Gly Val Arg Asp Ser Gly Ser Pro Pro Leu 
    530                 535                 540                 


His Ala Asn Thr Ser Leu His Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Val Leu His Pro Arg Pro Asp Trp Glu His Ser Ala Pro 
                565                 570                 575     


Gln Arg Leu Pro Arg Ser Ala Pro Pro Gly Ser Leu Val Thr Lys Val 
            580                 585                 590         


Thr Ala Val Asp Ala Asp Ala Gly His Asn Ala Trp Leu Ser Tyr Ser 
        595                 600                 605             


Leu Leu Pro Gln Ser Thr Ala Pro Gly Leu Phe Leu Val Ser Thr His 
    610                 615                 620                 


Thr Gly Glu Val Arg Thr Ala Arg Ala Leu Leu Glu Asp Asp Ser Asp 
625                 630                 635                 640 


Thr Gln Gln Val Val Val Leu Val Arg Asp Asn Gly Asp Pro Ser Leu 
                645                 650                 655     


Ser Ser Thr Ala Thr Val Leu Leu Val Leu Glu Asp Glu Asp Pro Glu 
            660                 665                 670         


Glu Met Pro Lys Ser Ser Asp Phe Leu Ile His Pro Pro Glu Arg Ser 
        675                 680                 685             


Asp Leu Thr Leu Tyr Leu Ile Val Ala Leu Ala Thr Val Ser Leu Leu 
    690                 695                 700                 


Ser Leu Val Thr Phe Thr Phe Leu Ser Ala Lys Cys Leu Gln Gly Asn 
705                 710                 715                 720 


Ala Asp Gly Asp Gly Gly Gly Gly Gln Cys Cys Arg Arg Gln Asp Ser 
                725                 730                 735     


Pro Ser Pro Asp Phe Tyr Lys Gln Ser Ser Pro Asn Leu Gln Val Ser 
            740                 745                 750         


Ser Asp Gly Thr Leu Lys Tyr Met Glu Val Thr Leu Arg Pro Thr Asp 
        755                 760                 765             


Ser Gln Ser His Cys Tyr Arg Thr Cys Phe Ser Pro Ala Ser Asp Gly 
    770                 775                 780                 


Ser Asp Phe Thr Phe Leu Arg Pro Leu Ser Val Gln Gln Pro Thr Ala 
785                 790                 795                 800 


Leu Ala Leu Glu Pro Asp Ala Ile Arg Ser Arg Ser Asn Thr Leu Arg 
                805                 810                 815     


Glu Arg Ser Gln Gln Ala Pro Pro Asn Thr Asp Trp Arg Phe Ser Gln 
            820                 825                 830         


Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly Asp Asp Thr Gly 
        835                 840                 845             


Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu Gln Ala Met Ile 
    850                 855                 860                 


Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser Thr Leu Gly Gly 
865                 870                 875                 880 


Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly Pro Gln Phe Thr 
                885                 890                 895     


Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr Ile Pro Gly Ser 
            900                 905                 910         


Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp Gly Lys Ala Pro 
        915                 920                 925             


Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys Lys Glu Lys Lys 
    930                 935                 940                 


<210>  5351
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  5351

Met Ala Ala Ser Pro Ala Arg Pro Ala Val Leu Ala Leu Thr Gly Leu 
1               5                   10                  15      


Ala Leu Leu Leu Leu Leu Cys Trp Gly Pro Gly Gly Ile Ser Gly Asn 
            20                  25                  30          


Lys Leu Lys Leu Met Leu Gln Lys Arg Glu Ala Pro Val Pro Thr Lys 
        35                  40                  45              


Thr Lys Val Ala Val Asp Glu Asn Lys Ala Lys Glu Phe Leu Gly Ser 
    50                  55                  60                  


Leu Lys Arg Gln Lys Arg Gln Leu Trp Asp Arg Thr Arg Pro Glu Val 
65                  70                  75                  80  


Gln Gln Trp Tyr Gln Gln Phe Leu Tyr Met Gly Phe Asp Glu Ala Lys 
                85                  90                  95      


Phe Glu Asp Asp Ile Thr Tyr Trp Leu Asn Arg Asp Arg Asn Gly His 
            100                 105                 110         


Glu Tyr Tyr Gly Asp Tyr Tyr Gln Arg His Tyr Asp Glu Asp Ser Ala 
        115                 120                 125             


Ile Gly Pro Arg Ser Pro Tyr Gly Phe Arg His Gly Ala Ser Val Asn 
    130                 135                 140                 


Tyr Asp Asp Tyr 
145             


<210>  5352
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  5352

Met Ser Phe Phe Gln Leu Leu Met Lys Arg Lys Glu Leu Ile Pro Leu 
1               5                   10                  15      


Val Val Phe Met Thr Val Ala Ala Gly Gly Ala Ser Ser Phe Ala Val 
            20                  25                  30          


Tyr Ser Leu Trp Lys Thr Asp Val Ile Leu Asp Arg Lys Lys Asn Pro 
        35                  40                  45              


Glu Pro Trp Glu Thr Val Asp Pro Thr Val Pro Gln Lys Leu Ile Thr 
    50                  55                  60                  


Ile Asn Gln Gln Trp Lys Pro Ile Glu Glu Leu Gln Asn Val Gln Arg 
65                  70                  75                  80  


Val Thr Lys 
            


<210>  5353
<211>  1237
<212>  PRT
<213>  Homo sapiens

<400>  5353

Met Asp Ser Gly Ala Gly Gly Arg Arg Cys Pro Glu Ala Ala Leu Leu 
1               5                   10                  15      


Ile Leu Gly Pro Pro Arg Met Glu His Leu Arg His Ser Pro Gly Pro 
            20                  25                  30          


Gly Gly Gln Arg Leu Leu Leu Pro Ser Met Leu Leu Ala Leu Leu Leu 
        35                  40                  45              


Leu Leu Ala Pro Ser Pro Gly His Ala Thr Arg Val Val Tyr Lys Val 
    50                  55                  60                  


Pro Glu Glu Gln Pro Pro Asn Thr Leu Ile Gly Ser Leu Ala Ala Asp 
65                  70                  75                  80  


Tyr Gly Phe Pro Asp Val Gly His Leu Tyr Lys Leu Glu Val Gly Ala 
                85                  90                  95      


Pro Tyr Leu Arg Val Asp Gly Lys Thr Gly Asp Ile Phe Thr Thr Glu 
            100                 105                 110         


Thr Ser Ile Asp Arg Glu Gly Leu Arg Glu Cys Gln Asn Gln Leu Pro 
        115                 120                 125             


Gly Asp Pro Cys Ile Leu Glu Phe Glu Val Ser Ile Thr Asp Leu Val 
    130                 135                 140                 


Gln Asn Gly Ser Pro Arg Leu Leu Glu Gly Gln Ile Glu Val Gln Asp 
145                 150                 155                 160 


Ile Asn Asp Asn Thr Pro Asn Phe Ala Ser Pro Val Ile Thr Leu Ala 
                165                 170                 175     


Ile Pro Glu Asn Thr Asn Ile Gly Ser Leu Phe Pro Ile Pro Leu Ala 
            180                 185                 190         


Ser Asp Arg Asp Ala Gly Pro Asn Gly Val Ala Ser Tyr Glu Leu Gln 
        195                 200                 205             


Ala Gly Pro Glu Ala Gln Glu Leu Phe Gly Leu Gln Val Ala Glu Asp 
    210                 215                 220                 


Gln Glu Glu Lys Gln Pro Gln Leu Ile Val Met Gly Asn Leu Asp Arg 
225                 230                 235                 240 


Glu Arg Trp Asp Ser Tyr Asp Leu Thr Ile Lys Val Gln Asp Gly Gly 
                245                 250                 255     


Ser Pro Pro Arg Ala Ser Ser Ala Leu Leu Arg Val Thr Val Leu Asp 
            260                 265                 270         


Thr Asn Asp Asn Ala Pro Lys Phe Glu Arg Pro Ser Tyr Glu Ala Glu 
        275                 280                 285             


Leu Ser Glu Asn Ser Pro Ile Gly His Ser Val Ile Gln Val Lys Ala 
    290                 295                 300                 


Asn Asp Ser Asp Gln Gly Ala Asn Ala Glu Ile Glu Tyr Thr Phe His 
305                 310                 315                 320 


Gln Ala Pro Glu Val Val Arg Arg Leu Leu Arg Leu Asp Arg Asn Thr 
                325                 330                 335     


Gly Leu Ile Thr Val Gln Gly Pro Val Asp Arg Glu Asp Leu Ser Thr 
            340                 345                 350         


Leu Arg Phe Ser Val Leu Ala Lys Asp Arg Gly Thr Asn Pro Lys Ser 
        355                 360                 365             


Ala Arg Ala Gln Val Val Val Thr Val Lys Asp Met Asn Asp Asn Ala 
    370                 375                 380                 


Pro Thr Ile Glu Ile Arg Gly Ile Gly Leu Val Thr His Gln Asp Gly 
385                 390                 395                 400 


Met Ala Asn Ile Ser Glu Asp Val Ala Glu Glu Thr Ala Val Ala Leu 
                405                 410                 415     


Val Gln Val Ser Asp Arg Asp Glu Gly Glu Asn Ala Ala Val Thr Cys 
            420                 425                 430         


Val Val Ala Gly Asp Val Pro Phe Gln Leu Arg Gln Ala Ser Glu Thr 
        435                 440                 445             


Gly Ser Asp Ser Lys Lys Lys Tyr Phe Leu Gln Thr Thr Thr Pro Leu 
    450                 455                 460                 


Asp Tyr Glu Lys Val Lys Asp Tyr Thr Ile Glu Ile Val Ala Val Asp 
465                 470                 475                 480 


Ser Gly Asn Pro Pro Leu Ser Ser Thr Asn Ser Leu Lys Val Gln Val 
                485                 490                 495     


Val Asp Val Asn Asp Asn Ala Pro Val Phe Thr Gln Ser Val Thr Glu 
            500                 505                 510         


Val Ala Phe Pro Glu Asn Asn Lys Pro Gly Glu Val Ile Ala Glu Ile 
        515                 520                 525             


Thr Ala Ser Asp Ala Asp Ser Gly Ser Asn Ala Glu Leu Val Tyr Ser 
    530                 535                 540                 


Leu Glu Pro Glu Pro Ala Ala Lys Gly Leu Phe Thr Ile Ser Pro Glu 
545                 550                 555                 560 


Thr Gly Glu Ile Gln Val Lys Thr Ser Leu Asp Arg Glu Gln Arg Glu 
                565                 570                 575     


Ser Tyr Glu Leu Lys Val Val Ala Ala Asp Arg Gly Ser Pro Ser Leu 
            580                 585                 590         


Gln Gly Thr Ala Thr Val Leu Val Asn Val Leu Asp Cys Asn Asp Asn 
        595                 600                 605             


Asp Pro Lys Phe Met Leu Ser Gly Tyr Asn Phe Ser Val Met Glu Asn 
    610                 615                 620                 


Met Pro Ala Leu Ser Pro Val Gly Met Val Thr Val Ile Asp Gly Asp 
625                 630                 635                 640 


Lys Gly Glu Asn Ala Gln Val Gln Leu Ser Val Glu Gln Asp Asn Gly 
                645                 650                 655     


Asp Phe Val Ile Gln Asn Gly Thr Gly Thr Ile Leu Ser Ser Leu Ser 
            660                 665                 670         


Phe Asp Arg Glu Gln Gln Ser Thr Tyr Thr Phe Gln Leu Lys Ala Val 
        675                 680                 685             


Asp Gly Gly Val Pro Pro Arg Ser Ala Tyr Val Gly Val Thr Ile Asn 
    690                 695                 700                 


Val Leu Asp Glu Asn Asp Asn Ala Pro Tyr Ile Thr Ala Pro Ser Asn 
705                 710                 715                 720 


Thr Ser His Lys Leu Leu Thr Pro Gln Thr Arg Leu Gly Glu Thr Val 
                725                 730                 735     


Ser Gln Val Ala Ala Glu Asp Phe Asp Ser Gly Val Asn Ala Glu Leu 
            740                 745                 750         


Ile Tyr Ser Ile Ala Gly Gly Asn Pro Tyr Gly Leu Phe Gln Ile Gly 
        755                 760                 765             


Ser His Ser Gly Ala Ile Thr Leu Glu Lys Glu Ile Glu Arg Arg His 
    770                 775                 780                 


His Gly Leu His Arg Leu Val Val Lys Val Ser Asp Arg Gly Lys Pro 
785                 790                 795                 800 


Pro Arg Tyr Gly Thr Ala Leu Val His Leu Tyr Val Asn Glu Thr Leu 
                805                 810                 815     


Ala Asn Arg Thr Leu Leu Glu Thr Leu Leu Gly His Ser Leu Asp Thr 
            820                 825                 830         


Pro Leu Asp Ile Asp Ile Ala Gly Asp Pro Glu Tyr Glu Arg Ser Lys 
        835                 840                 845             


Gln Arg Gly Asn Ile Leu Phe Gly Val Val Ala Gly Val Val Ala Val 
    850                 855                 860                 


Ala Leu Leu Ile Ala Leu Ala Val Leu Val Arg Tyr Cys Arg Gln Arg 
865                 870                 875                 880 


Glu Ala Lys Ser Gly Tyr Gln Ala Gly Lys Lys Glu Thr Lys Asp Leu 
                885                 890                 895     


Tyr Ala Pro Lys Pro Ser Gly Lys Ala Ser Lys Gly Asn Lys Ser Lys 
            900                 905                 910         


Gly Lys Lys Ser Lys Ser Pro Lys Pro Val Lys Pro Val Glu Asp Glu 
        915                 920                 925             


Asp Glu Ala Gly Leu Gln Lys Ser Leu Lys Phe Asn Leu Met Ser Asp 
    930                 935                 940                 


Ala Pro Gly Asp Ser Pro Arg Ile His Leu Pro Leu Asn Tyr Pro Pro 
945                 950                 955                 960 


Gly Ser Pro Asp Leu Gly Arg His Tyr Arg Ser Asn Ser Pro Leu Pro 
                965                 970                 975     


Ser Ile Gln Leu Gln Pro Gln Ser Pro Ser Ala Ser Lys Lys His Gln 
            980                 985                 990         


Val Val Gln Asp Leu Pro Pro Ala  Asn Thr Phe Val Gly  Thr Gly Asp 
        995                 1000                 1005             


Thr Thr  Ser Thr Gly Ser Glu  Gln Tyr Ser Asp Tyr  Ser Tyr Arg 
    1010                 1015                 1020             


Thr Asn  Pro Pro Lys Tyr Pro  Ser Lys Gln Leu Pro  His Arg Arg 
    1025                 1030                 1035             


Val Thr  Phe Ser Ala Thr Ser  Gln Ala Gln Glu Leu  Gln Asp Pro 
    1040                 1045                 1050             


Ser Gln  His Ser Tyr Tyr Asp  Ser Gly Leu Glu Glu  Ser Glu Thr 
    1055                 1060                 1065             


Pro Ser  Ser Lys Ser Ser Ser  Gly Pro Arg Leu Gly  Pro Leu Ala 
    1070                 1075                 1080             


Leu Pro  Glu Asp His Tyr Glu  Arg Thr Thr Pro Asp  Gly Ser Ile 
    1085                 1090                 1095             


Gly Glu  Met Glu His Pro Glu  Asn Asp Leu Arg Pro  Leu Pro Asp 
    1100                 1105                 1110             


Val Ala  Met Thr Gly Thr Cys  Thr Arg Glu Cys Ser  Glu Phe Gly 
    1115                 1120                 1125             


His Ser  Asp Thr Cys Trp Met  Pro Gly Gln Ser Ser  Pro Ser Arg 
    1130                 1135                 1140             


Arg Thr  Lys Ser Ser Ala Leu  Lys Leu Ser Thr Phe  Val Pro Tyr 
    1145                 1150                 1155             


Gln Asp  Arg Gly Gly Gln Glu  Pro Ala Gly Ala Gly  Ser Pro Ser 
    1160                 1165                 1170             


Pro Pro  Glu Asp Arg Asn Thr  Lys Thr Ala Pro Val  Arg Leu Leu 
    1175                 1180                 1185             


Pro Ser  Tyr Ser Ala Phe Ser  His Ser Ser His Asp  Ser Cys Lys 
    1190                 1195                 1200             


Asp Ser  Ala Thr Leu Glu Glu  Ile Pro Leu Thr Gln  Thr Ser Asp 
    1205                 1210                 1215             


Phe Pro  Pro Ala Ala Thr Pro  Ala Ser Ala Gln Thr  Ala Lys Arg 
    1220                 1225                 1230             


Glu Ile  Tyr Leu 
    1235         


<210>  5354
<211>  1044
<212>  PRT
<213>  Homo sapiens

<400>  5354

Met Val Leu Ser Leu Thr Gly Leu Ile Ala Phe Ser Phe Leu Gln Ala 
1               5                   10                  15      


Thr Leu Ala Leu Asn Pro Glu Asp Pro Asn Val Cys Ser His Trp Glu 
            20                  25                  30          


Ser Tyr Ala Val Thr Val Gln Glu Ser Tyr Ala His Pro Phe Asp Gln 
        35                  40                  45              


Ile Tyr Tyr Thr Arg Cys Thr Asp Ile Leu Asn Trp Phe Lys Cys Thr 
    50                  55                  60                  


Arg His Arg Ile Ser Tyr Lys Thr Ala Tyr Arg Arg Gly Leu Arg Thr 
65                  70                  75                  80  


Met Tyr Arg Arg Arg Ser Gln Cys Cys Pro Gly Tyr Tyr Glu Ser Gly 
                85                  90                  95      


Asp Phe Cys Ile Pro Leu Cys Thr Glu Glu Cys Val His Gly Arg Cys 
            100                 105                 110         


Val Ser Pro Asp Thr Cys His Cys Glu Pro Gly Trp Gly Gly Pro Asp 
        115                 120                 125             


Cys Ser Ser Gly Cys Asp Ser Asp His Trp Gly Pro His Cys Ser Asn 
    130                 135                 140                 


Arg Cys Gln Cys Gln Asn Gly Ala Leu Cys Asn Pro Ile Thr Gly Ala 
145                 150                 155                 160 


Cys Val Cys Ala Ala Gly Phe Arg Gly Trp Arg Cys Glu Glu Leu Cys 
                165                 170                 175     


Ala Pro Gly Thr His Gly Lys Gly Cys Gln Leu Pro Cys Gln Cys Arg 
            180                 185                 190         


His Gly Ala Ser Cys Asp Pro Arg Ala Gly Glu Cys Leu Cys Ala Pro 
        195                 200                 205             


Gly Tyr Thr Gly Val Tyr Cys Glu Glu Leu Cys Pro Pro Gly Ser His 
    210                 215                 220                 


Gly Ala His Cys Glu Leu Arg Cys Pro Cys Gln Asn Gly Gly Thr Cys 
225                 230                 235                 240 


His His Ile Thr Gly Glu Cys Ala Cys Pro Pro Gly Trp Thr Gly Ala 
                245                 250                 255     


Val Cys Ala Gln Pro Cys Pro Pro Gly Thr Phe Gly Gln Asn Cys Ser 
            260                 265                 270         


Gln Asp Cys Pro Cys His His Gly Gly Gln Cys Asp His Val Thr Gly 
        275                 280                 285             


Gln Cys His Cys Thr Ala Gly Tyr Met Gly Asp Arg Cys Gln Glu Glu 
    290                 295                 300                 


Cys Pro Phe Gly Ser Phe Gly Phe Gln Cys Ser Gln His Cys Asp Cys 
305                 310                 315                 320 


His Asn Gly Gly Gln Cys Ser Pro Thr Thr Gly Ala Cys Glu Cys Glu 
                325                 330                 335     


Pro Gly Tyr Lys Gly Pro Arg Cys Gln Glu Arg Leu Cys Pro Glu Gly 
            340                 345                 350         


Leu His Gly Pro Gly Cys Thr Leu Pro Cys Pro Cys Asp Ala Asp Asn 
        355                 360                 365             


Thr Ile Ser Cys His Pro Val Thr Gly Ala Cys Thr Cys Gln Pro Gly 
    370                 375                 380                 


Trp Ser Gly His His Cys Asn Glu Ser Cys Pro Val Gly Tyr Tyr Gly 
385                 390                 395                 400 


Asp Gly Cys Gln Leu Pro Cys Thr Cys Gln Asn Gly Ala Asp Cys His 
                405                 410                 415     


Ser Ile Thr Gly Gly Cys Thr Cys Ala Pro Gly Phe Met Gly Glu Val 
            420                 425                 430         


Cys Ala Val Ser Cys Ala Ala Gly Thr Tyr Gly Pro Asn Cys Ser Ser 
        435                 440                 445             


Ile Cys Ser Cys Asn Asn Gly Gly Thr Cys Ser Pro Val Asp Gly Ser 
    450                 455                 460                 


Cys Thr Cys Lys Glu Gly Trp Gln Gly Leu Asp Cys Thr Leu Pro Cys 
465                 470                 475                 480 


Pro Ser Gly Thr Trp Gly Leu Asn Cys Asn Glu Ser Cys Thr Cys Ala 
                485                 490                 495     


Asn Gly Ala Ala Cys Ser Pro Ile Asp Gly Ser Cys Ser Cys Thr Pro 
            500                 505                 510         


Gly Trp Leu Gly Asp Thr Cys Glu Leu Pro Cys Pro Asp Gly Thr Phe 
        515                 520                 525             


Gly Leu Asn Cys Ser Glu His Cys Asp Cys Ser His Ala Asp Gly Cys 
    530                 535                 540                 


Asp Pro Val Thr Gly His Cys Cys Cys Leu Ala Gly Trp Thr Gly Ile 
545                 550                 555                 560 


Arg Cys Asp Ser Thr Cys Pro Pro Gly Arg Trp Gly Pro Asn Cys Ser 
                565                 570                 575     


Val Ser Cys Ser Cys Glu Asn Gly Gly Ser Cys Ser Pro Glu Asp Gly 
            580                 585                 590         


Ser Cys Glu Cys Ala Pro Gly Phe Arg Gly Pro Leu Cys Gln Arg Ile 
        595                 600                 605             


Cys Pro Pro Gly Phe Tyr Gly His Gly Cys Ala Gln Pro Cys Pro Leu 
    610                 615                 620                 


Cys Val His Ser Ser Arg Pro Cys His His Ile Ser Gly Ile Cys Glu 
625                 630                 635                 640 


Cys Leu Pro Gly Phe Ser Gly Ala Leu Cys Asn Gln Val Cys Ala Gly 
                645                 650                 655     


Gly Tyr Phe Gly Gln Asp Cys Ala Gln Leu Cys Ser Cys Ala Asn Asn 
            660                 665                 670         


Gly Thr Cys Ser Pro Ile Asp Gly Ser Cys Gln Cys Phe Pro Gly Trp 
        675                 680                 685             


Ile Gly Lys Asp Cys Ser Gln Ala Cys Pro Pro Gly Phe Trp Gly Pro 
    690                 695                 700                 


Ala Cys Phe His Ala Cys Ser Cys His Asn Gly Ala Ser Cys Ser Ala 
705                 710                 715                 720 


Glu Asp Gly Ala Cys His Cys Thr Pro Gly Trp Thr Gly Leu Phe Cys 
                725                 730                 735     


Thr Gln Arg Cys Pro Ala Ala Phe Phe Gly Lys Asp Cys Gly Arg Val 
            740                 745                 750         


Cys Gln Cys Gln Asn Gly Ala Ser Cys Asp His Ile Ser Gly Lys Cys 
        755                 760                 765             


Thr Cys Arg Thr Gly Phe Thr Gly Gln His Cys Glu Gln Arg Cys Ala 
    770                 775                 780                 


Pro Gly Thr Phe Gly Tyr Gly Cys Gln Gln Leu Cys Glu Cys Met Asn 
785                 790                 795                 800 


Asn Ser Thr Cys Asp His Val Thr Gly Thr Cys Tyr Cys Ser Pro Gly 
                805                 810                 815     


Phe Lys Gly Ile Arg Cys Asp Gln Ala Ala Leu Met Met Glu Glu Leu 
            820                 825                 830         


Asn Pro Tyr Thr Lys Ile Ser Pro Ala Leu Gly Ala Glu Arg His Ser 
        835                 840                 845             


Val Gly Ala Val Thr Gly Ile Met Leu Leu Leu Phe Leu Ile Val Val 
    850                 855                 860                 


Leu Leu Gly Leu Phe Ala Trp His Arg Arg Arg Gln Lys Glu Lys Gly 
865                 870                 875                 880 


Arg Asp Leu Ala Pro Arg Val Ser Tyr Thr Pro Ala Met Arg Met Thr 
                885                 890                 895     


Ser Thr Asp Tyr Ser Leu Ser Gly Ala Cys Gly Met Asp Arg Arg Gln 
            900                 905                 910         


Asn Thr Tyr Ile Met Asp Lys Gly Phe Lys Asp Tyr Met Lys Glu Ser 
        915                 920                 925             


Val Cys Ser Ser Ser Thr Cys Ser Leu Asn Ser Ser Glu Asn Pro Tyr 
    930                 935                 940                 


Ala Thr Ile Lys Asp Pro Pro Ile Leu Thr Cys Lys Leu Pro Glu Ser 
945                 950                 955                 960 


Ser Tyr Val Glu Met Lys Ser Pro Val His Met Gly Ser Pro Tyr Thr 
                965                 970                 975     


Asp Val Pro Ser Leu Ser Thr Ser Asn Lys Asn Ile Tyr Glu Val Glu 
            980                 985                 990         


Pro Thr Val Ser Val Val Gln Glu  Gly Cys Gly His Asn  Ser Ser Tyr 
        995                 1000                 1005             


Ile Gln  Asn Ala Tyr Asp Leu  Pro Arg Asn Ser His  Ile Pro Gly 
    1010                 1015                 1020             


His Tyr  Asp Leu Leu Pro Val  Arg Gln Ser Pro Ala  Asn Gly Pro 
    1025                 1030                 1035             


Ser Gln  Asp Lys Gln Ser 
    1040                 


<210>  5355
<211>  1140
<212>  PRT
<213>  Homo sapiens

<400>  5355

Met Val Ile Ser Leu Asn Ser Cys Leu Ser Phe Ile Cys Leu Leu Leu 
1               5                   10                  15      


Cys His Trp Ile Gly Thr Ala Ser Pro Leu Asn Leu Glu Asp Pro Asn 
            20                  25                  30          


Val Cys Ser His Trp Glu Ser Tyr Ser Val Thr Val Gln Glu Ser Tyr 
        35                  40                  45              


Pro His Pro Phe Asp Gln Ile Tyr Tyr Thr Ser Cys Thr Asp Ile Leu 
    50                  55                  60                  


Asn Trp Phe Lys Cys Thr Arg His Arg Val Ser Tyr Arg Thr Ala Tyr 
65                  70                  75                  80  


Arg His Gly Glu Lys Thr Met Tyr Arg Arg Lys Ser Gln Cys Cys Pro 
                85                  90                  95      


Gly Phe Tyr Glu Ser Gly Glu Met Cys Val Pro His Cys Ala Asp Lys 
            100                 105                 110         


Cys Val His Gly Arg Cys Ile Ala Pro Asn Thr Cys Gln Cys Glu Pro 
        115                 120                 125             


Gly Trp Gly Gly Thr Asn Cys Ser Ser Ala Cys Asp Gly Asp His Trp 
    130                 135                 140                 


Gly Pro His Cys Thr Ser Arg Cys Gln Cys Lys Asn Gly Ala Leu Cys 
145                 150                 155                 160 


Asn Pro Ile Thr Gly Ala Cys His Cys Ala Ala Gly Phe Arg Gly Trp 
                165                 170                 175     


Arg Cys Glu Asp Arg Cys Glu Gln Gly Thr Tyr Gly Asn Asp Cys His 
            180                 185                 190         


Gln Arg Cys Gln Cys Gln Asn Gly Ala Thr Cys Asp His Val Thr Gly 
        195                 200                 205             


Glu Cys Arg Cys Pro Pro Gly Tyr Thr Gly Ala Phe Cys Glu Asp Leu 
    210                 215                 220                 


Cys Pro Pro Gly Lys His Gly Pro Gln Cys Glu Gln Arg Cys Pro Cys 
225                 230                 235                 240 


Gln Asn Gly Gly Val Cys His His Val Thr Gly Glu Cys Ser Cys Pro 
                245                 250                 255     


Ser Gly Trp Met Gly Thr Val Cys Gly Gln Pro Cys Pro Glu Gly Arg 
            260                 265                 270         


Phe Gly Lys Asn Cys Ser Gln Glu Cys Gln Cys His Asn Gly Gly Thr 
        275                 280                 285             


Cys Asp Ala Ala Thr Gly Gln Cys His Cys Ser Pro Gly Tyr Thr Gly 
    290                 295                 300                 


Glu Arg Cys Gln Asp Glu Cys Pro Val Gly Thr Tyr Gly Val Leu Cys 
305                 310                 315                 320 


Ala Glu Thr Cys Gln Cys Val Asn Gly Gly Lys Cys Tyr His Val Ser 
                325                 330                 335     


Gly Ala Cys Leu Cys Glu Ala Gly Phe Ala Gly Glu Arg Cys Glu Ala 
            340                 345                 350         


Arg Leu Cys Pro Glu Gly Leu Tyr Gly Ile Lys Cys Asp Lys Arg Cys 
        355                 360                 365             


Pro Cys His Leu Glu Asn Thr His Ser Cys His Pro Met Ser Gly Glu 
    370                 375                 380                 


Cys Ala Cys Lys Pro Gly Trp Ser Gly Leu Tyr Cys Asn Glu Thr Cys 
385                 390                 395                 400 


Ser Pro Gly Phe Tyr Gly Glu Ala Cys Gln Gln Ile Cys Ser Cys Gln 
                405                 410                 415     


Asn Gly Ala Asp Cys Asp Ser Val Thr Gly Lys Cys Thr Cys Ala Pro 
            420                 425                 430         


Gly Phe Lys Gly Ile Asp Cys Ser Thr Pro Cys Pro Leu Gly Thr Tyr 
        435                 440                 445             


Gly Ile Asn Cys Ser Ser Arg Cys Gly Cys Lys Asn Asp Ala Val Cys 
    450                 455                 460                 


Ser Pro Val Asp Gly Ser Cys Thr Cys Lys Ala Gly Trp His Gly Val 
465                 470                 475                 480 


Asp Cys Ser Ile Arg Cys Pro Ser Gly Thr Trp Gly Phe Gly Cys Asn 
                485                 490                 495     


Leu Thr Cys Gln Cys Leu Asn Gly Gly Ala Cys Asn Thr Leu Asp Gly 
            500                 505                 510         


Thr Cys Thr Cys Ala Pro Gly Trp Arg Gly Glu Lys Cys Glu Leu Pro 
        515                 520                 525             


Cys Gln Asp Gly Thr Tyr Gly Leu Asn Cys Ala Glu Arg Cys Asp Cys 
    530                 535                 540                 


Ser His Ala Asp Gly Cys His Pro Thr Thr Gly His Cys Arg Cys Leu 
545                 550                 555                 560 


Pro Gly Trp Ser Gly Val His Cys Asp Ser Val Cys Ala Glu Gly Arg 
                565                 570                 575     


Trp Gly Pro Asn Cys Ser Leu Pro Cys Tyr Cys Lys Asn Gly Ala Ser 
            580                 585                 590         


Cys Ser Pro Asp Asp Gly Ile Cys Glu Cys Ala Pro Gly Phe Arg Gly 
        595                 600                 605             


Thr Thr Cys Gln Arg Ile Cys Ser Pro Gly Phe Tyr Gly His Arg Cys 
    610                 615                 620                 


Ser Gln Thr Cys Pro Gln Cys Val His Ser Ser Gly Pro Cys His His 
625                 630                 635                 640 


Ile Thr Gly Leu Cys Asp Cys Leu Pro Gly Phe Thr Gly Ala Leu Cys 
                645                 650                 655     


Asn Glu Val Cys Pro Ser Gly Arg Phe Gly Lys Asn Cys Ala Gly Ile 
            660                 665                 670         


Cys Thr Cys Thr Asn Asn Gly Thr Cys Asn Pro Ile Asp Arg Ser Cys 
        675                 680                 685             


Gln Cys Tyr Pro Gly Trp Ile Gly Ser Asp Cys Ser Gln Pro Cys Pro 
    690                 695                 700                 


Pro Ala His Trp Gly Pro Asn Cys Ile His Thr Cys Asn Cys His Asn 
705                 710                 715                 720 


Gly Ala Phe Cys Ser Ala Tyr Asp Gly Glu Cys Lys Cys Thr Pro Gly 
                725                 730                 735     


Trp Thr Gly Leu Tyr Cys Thr Gln Arg Cys Pro Leu Gly Phe Tyr Gly 
            740                 745                 750         


Lys Asp Cys Ala Leu Ile Cys Gln Cys Gln Asn Gly Ala Asp Cys Asp 
        755                 760                 765             


His Ile Ser Gly Gln Cys Thr Cys Arg Thr Gly Phe Met Gly Arg His 
    770                 775                 780                 


Cys Glu Gln Lys Cys Pro Ser Gly Thr Tyr Gly Tyr Gly Cys Arg Gln 
785                 790                 795                 800 


Ile Cys Asp Cys Leu Asn Asn Ser Thr Cys Asp His Ile Thr Gly Thr 
                805                 810                 815     


Cys Tyr Cys Ser Pro Gly Trp Lys Gly Ala Arg Cys Asp Gln Ala Gly 
            820                 825                 830         


Val Ile Ile Val Gly Asn Leu Asn Ser Leu Ser Arg Thr Ser Thr Ala 
        835                 840                 845             


Leu Pro Ala Asp Ser Tyr Gln Ile Gly Ala Ile Ala Gly Ile Ile Ile 
    850                 855                 860                 


Leu Val Leu Val Val Leu Phe Leu Leu Ala Leu Phe Ile Ile Tyr Arg 
865                 870                 875                 880 


His Lys Gln Lys Gly Lys Glu Ser Ser Met Pro Ala Val Thr Tyr Thr 
                885                 890                 895     


Pro Ala Met Arg Val Val Asn Ala Asp Tyr Thr Ile Ser Gly Thr Leu 
            900                 905                 910         


Pro His Ser Asn Gly Gly Asn Ala Asn Ser His Tyr Phe Thr Asn Pro 
        915                 920                 925             


Ser Tyr His Thr Leu Thr Gln Cys Ala Thr Ser Pro His Val Asn Asn 
    930                 935                 940                 


Arg Asp Arg Met Thr Val Thr Lys Ser Lys Asn Asn Gln Leu Phe Val 
945                 950                 955                 960 


Asn Leu Lys Asn Val Asn Pro Gly Lys Arg Gly Pro Val Gly Asp Cys 
                965                 970                 975     


Thr Gly Thr Leu Pro Ala Asp Trp Lys His Gly Gly Tyr Leu Asn Glu 
            980                 985                 990         


Leu Gly Ala Phe Gly Leu Asp Arg  Ser Tyr Met Gly Lys  Ser Leu Lys 
        995                 1000                 1005             


Asp Leu  Gly Lys Asn Ser Glu  Tyr Asn Ser Ser Asn  Cys Ser Leu 
    1010                 1015                 1020             


Ser Ser  Ser Glu Asn Pro Tyr  Ala Thr Ile Lys Asp  Pro Pro Val 
    1025                 1030                 1035             


Leu Ile  Pro Lys Ser Ser Glu  Cys Gly Tyr Val Glu  Met Lys Ser 
    1040                 1045                 1050             


Pro Ala  Arg Arg Asp Ser Pro  Tyr Ala Glu Ile Asn  Asn Ser Thr 
    1055                 1060                 1065             


Ser Ala  Asn Arg Asn Val Tyr  Glu Val Glu Pro Thr  Val Ser Val 
    1070                 1075                 1080             


Val Gln  Gly Val Phe Ser Asn  Asn Gly Arg Leu Ser  Gln Asp Pro 
    1085                 1090                 1095             


Tyr Asp  Leu Pro Lys Asn Ser  His Ile Pro Cys His  Tyr Asp Leu 
    1100                 1105                 1110             


Leu Pro  Val Arg Asp Ser Ser  Ser Ser Pro Lys Gln  Glu Asp Ser 
    1115                 1120                 1125             


Gly Gly  Ser Ser Ser Asn Ser  Ser Ser Ser Ser Glu  
    1130                 1135                 1140 


<210>  5356
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  5356

Met Ala Gln Arg Lys Asn Ala Lys Ser Ser Gly Asn Ser Ser Ser Ser 
1               5                   10                  15      


Gly Ser Gly Ser Gly Ser Thr Ser Ala Gly Ser Ser Ser Pro Gly Ala 
            20                  25                  30          


Arg Arg Glu Thr Lys His Gly Gly His Lys Asn Gly Arg Lys Gly Gly 
        35                  40                  45              


Leu Ser Gly Thr Ser Phe Phe Thr Trp Phe Met Val Ile Ala Leu Leu 
    50                  55                  60                  


Gly Val Trp Thr Ser Val Ala Val Val Trp Phe Asp Leu Val Asp Tyr 
65                  70                  75                  80  


Glu Glu Val Leu Gly Lys Leu Gly Ile Tyr Asp Ala Asp Gly Asp Gly 
                85                  90                  95      


Asp Phe Asp Val Asp Asp Ala Lys Val Leu Leu Gly Leu Lys Glu Arg 
            100                 105                 110         


Ser Thr Ser Glu Pro Ala Val Pro Pro Glu Glu Ala Glu Pro His Thr 
        115                 120                 125             


Glu Pro Glu Glu Gln Val Pro Val Glu Ala Glu Pro Gln Asn Ile Glu 
    130                 135                 140                 


Asp Glu Ala Lys Glu Gln Ile Gln Ser Leu Leu His Glu Met Val His 
145                 150                 155                 160 


Ala Glu His Val Glu Gly Glu Asp Leu Gln Gln Glu Asp Gly Pro Thr 
                165                 170                 175     


Gly Glu Pro Gln Gln Glu Asp Asp Glu Phe Leu Met Ala Thr Asp Val 
            180                 185                 190         


Asp Asp Arg Phe Glu Thr Leu Glu Pro Glu Val Ser His Glu Glu Thr 
        195                 200                 205             


Glu His Ser Tyr His Val Glu Glu Thr Val Ser Gln Asp Cys Asn Gln 
    210                 215                 220                 


Asp Met Glu Glu Met Met Ser Glu Gln Glu Asn Pro Asp Ser Ser Glu 
225                 230                 235                 240 


Pro Val Val Glu Asp Glu Arg Leu His His Asp Thr Asp Asp Val Thr 
                245                 250                 255     


Tyr Gln Val Tyr Glu Glu Gln Ala Val Tyr Glu Pro Leu Glu Asn Glu 
            260                 265                 270         


Gly Ile Glu Ile Thr Glu Val Thr Ala Pro Pro Glu Asp Asn Pro Val 
        275                 280                 285             


Glu Asp Ser Gln Val Ile Val Glu Glu Val Ser Ile Phe Pro Val Glu 
    290                 295                 300                 


Glu Gln Gln Glu Val Pro Pro Asp Thr 
305                 310             


<210>  5357
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  5357

Met Ala Glu Asp Lys Glu Thr Lys His Gly Gly His Lys Asn Gly Arg 
1               5                   10                  15      


Lys Gly Gly Leu Ser Gly Thr Ser Phe Phe Thr Trp Phe Met Val Ile 
            20                  25                  30          


Ala Leu Leu Gly Val Trp Thr Ser Val Ala Val Val Trp Phe Asp Leu 
        35                  40                  45              


Val Asp Tyr Glu Glu Val Leu Gly Lys Leu Gly Ile Tyr Asp Ala Asp 
    50                  55                  60                  


Gly Asp Gly Asp Phe Asp Val Asp Asp Ala Lys Val Leu Leu Glu Gly 
65                  70                  75                  80  


Pro Ser Gly Val Ala Lys Arg Lys Thr Lys Ala Lys Val Lys Glu Leu 
                85                  90                  95      


Thr Lys Glu Glu Leu Lys Lys Glu Lys Glu Lys Pro Glu Ser Arg Lys 
            100                 105                 110         


Glu Ser Lys Asn Glu Glu Arg Lys Lys Gly Lys Lys Glu Asp Val Arg 
        115                 120                 125             


Lys Asp Lys Lys Ile Ala Asp Ala Asp Leu Ser Arg Lys Glu Ser Pro 
    130                 135                 140                 


Lys Gly Lys Lys Asp Arg Glu Lys Glu Lys Val Asp Leu Glu Lys Ser 
145                 150                 155                 160 


Ala Lys Thr Lys Glu Asn Arg Lys Lys Ser Thr Asn Met Lys Asp Val 
                165                 170                 175     


Ser Ser Lys Met Ala Ser Arg Asp Lys Asp Asp Arg Lys Glu Ser Arg 
            180                 185                 190         


Ser Ser Thr Arg Tyr Ala His Leu Thr Lys Gly Asn Thr Gln Lys Arg 
        195                 200                 205             


Asn Gly 
    210 


<210>  5358
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  5358

Met Ala Glu Asp Lys Glu Thr Lys His Gly Gly His Lys Asn Gly Arg 
1               5                   10                  15      


Lys Gly Gly Leu Ser Gly Thr Ser Phe Phe Thr Trp Phe Met Val Ile 
            20                  25                  30          


Ala Leu Leu Gly Val Trp Thr Ser Val Ala Val Val Trp Phe Asp Leu 
        35                  40                  45              


Val Asp Tyr Glu Glu Val Leu Ala Lys Ala Lys Asp Phe Arg Tyr Asn 
    50                  55                  60                  


Leu Ser Glu Val Leu Gln Gly Lys Leu Gly Ile Tyr Asp Ala Asp Gly 
65                  70                  75                  80  


Asp Gly Asp Phe Asp Val Asp Asp Ala Lys Val Leu Leu Gly Leu Lys 
                85                  90                  95      


Glu Arg Ser Thr Ser Glu Pro Ala Val Pro Pro Glu Glu Ala Glu Pro 
            100                 105                 110         


His Thr Glu Pro Glu Glu Gln Val Pro Val Glu Ala Glu Pro Gln Asn 
        115                 120                 125             


Ile Glu Asp Glu Ala Lys Glu Gln Ile Gln Ser Leu Leu His Glu Met 
    130                 135                 140                 


Val His Ala Glu His Val Glu Gly Glu Asp Leu Gln Gln Glu Asp Gly 
145                 150                 155                 160 


Pro Thr Gly Glu Pro Gln Gln Glu Asp Asp Glu Phe Leu Met Ala Thr 
                165                 170                 175     


Asp Val Asp Asp Arg Phe Glu Thr Leu Glu Pro Glu Val Ser His Glu 
            180                 185                 190         


Glu Thr Glu His Ser Tyr His Val Glu Glu Thr Val Ser Gln Asp Cys 
        195                 200                 205             


Asn Gln Asp Met Glu Glu Met Met Ser Glu Gln Glu Asn Pro Asp Ser 
    210                 215                 220                 


Ser Glu Pro Val Val Glu Asp Glu Arg Leu His His Asp Thr Asp Asp 
225                 230                 235                 240 


Val Thr Tyr Gln Val Tyr Glu Glu Gln Ala Val Tyr Glu Pro Leu Glu 
                245                 250                 255     


Asn Glu Gly Ile Glu Ile Thr Glu Val Thr Ala Pro Pro Glu Asp Asn 
            260                 265                 270         


Pro Val Glu Asp Ser Gln Val Ile Val Glu Glu Val Ser Ile Phe Pro 
        275                 280                 285             


Val Glu Glu Gln Gln Glu Val Pro Pro Asp Thr 
    290                 295                 


<210>  5359
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  5359

Met Gly Lys Ala Ala Ala Ala Val Ala Phe Gly Ala Glu Val Gly Val 
1               5                   10                  15      


Arg Leu Ala Leu Phe Ala Ala Phe Leu Val Thr Glu Leu Leu Pro Pro 
            20                  25                  30          


Phe Gln Arg Leu Ile Gln Pro Glu Glu Met Trp Leu Tyr Arg Asn Pro 
        35                  40                  45              


Tyr Val Glu Ala Glu Tyr Phe Pro Thr Lys Pro Met Phe Val Ile Ala 
    50                  55                  60                  


Phe Leu Ser Pro Leu Ser Leu Ile Phe Leu Ala Lys Phe Leu Lys Lys 
65                  70                  75                  80  


Ala Asp Thr Arg Asp Ser Arg Gln Ala Cys Leu Ala Ala Ser Leu Ala 
                85                  90                  95      


Leu Ala Leu Asn Gly Val Phe Thr Asn Thr Ile Lys Leu Ile Val Gly 
            100                 105                 110         


Arg Pro Arg Pro Asp Phe Phe Tyr Arg Cys Phe Pro Asp Gly Leu Ala 
        115                 120                 125             


His Ser Asp Leu Met Cys Thr Gly Asp Lys Asp Val Val Asn Glu Gly 
    130                 135                 140                 


Arg Lys Ser Phe Pro Ser Gly His Ser Ser Phe Ala Phe Ala Gly Leu 
145                 150                 155                 160 


Ala Phe Ala Ser Phe Tyr Leu Ala Gly Lys Leu His Cys Phe Thr Pro 
                165                 170                 175     


Gln Gly Arg Gly Lys Ser Trp Arg Phe Cys Ala Phe Leu Ser Pro Leu 
            180                 185                 190         


Leu Phe Ala Ala Val Ile Ala Leu Ser Arg Thr Cys Asp Tyr Lys His 
        195                 200                 205             


His Trp Gln Gly Pro Phe Lys Trp 
    210                 215     


<210>  5360
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  5360

Met Ala Ser Arg Ala Gly Pro Arg Ala Ala Gly Thr Asp Gly Ser Asp 
1               5                   10                  15      


Phe Gln His Arg Glu Arg Val Ala Met His Tyr Gln Met Ser Val Thr 
            20                  25                  30          


Leu Lys Tyr Glu Ile Lys Lys Leu Ile Tyr Val His Leu Val Ile Trp 
        35                  40                  45              


Leu Leu Leu Val Ala Lys Met Ser Val Gly His Leu Arg Leu Leu Ser 
    50                  55                  60                  


His Asp Gln Val Ala Met Pro Tyr Gln Trp Glu Tyr Pro Tyr Leu Leu 
65                  70                  75                  80  


Ser Ile Leu Pro Ser Leu Leu Gly Leu Leu Ser Phe Pro Arg Asn Asn 
                85                  90                  95      


Ile Ser Tyr Leu Val Leu Ser Met Ile Ser Met Gly Leu Phe Ser Ile 
            100                 105                 110         


Ala Pro Leu Ile Tyr Gly Ser Met Glu Met Phe Pro Ala Ala Gln Gln 
        115                 120                 125             


Leu Tyr Arg His Gly Lys Ala Tyr Arg Phe Leu Phe Gly Phe Ser Ala 
    130                 135                 140                 


Val Ser Ile Met Tyr Leu Val Leu Val Leu Ala Val Gln Val His Ala 
145                 150                 155                 160 


Trp Gln Leu Tyr Tyr Ser Lys Lys Leu Leu Asp Ser Trp Phe Thr Ser 
                165                 170                 175     


Thr Gln Glu Lys Lys His Lys 
            180             


<210>  5361
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  5361

Met Val Ala Gly Trp Leu Thr Asn Tyr Ser Gln Asp Ser Val Thr Phe 
1               5                   10                  15      


Glu Asp Val Ala Val Asp Phe Thr Gln Glu Glu Trp Thr Leu Leu Asp 
            20                  25                  30          


Gln Thr Gln Arg Asn Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Lys 
        35                  40                  45              


Asn Leu Val Ala Val Asp Trp Glu Ser His Ile Asn Thr Lys Trp Ser 
    50                  55                  60                  


Ala Pro Gln Gln Asn Phe Leu Gln Gly Lys Thr Ser Ser Val Val Glu 
65                  70                  75                  80  


Met Glu Arg Asn His Phe Gly Glu Glu Leu Phe Asp Phe Asn Gln Cys 
                85                  90                  95      


Glu Lys Ala Leu Ser Glu His Ser Cys Leu Lys Thr His Arg Arg Thr 
            100                 105                 110         


Tyr Phe Arg Lys Lys Thr Cys Glu Cys Asn Gln Cys Glu Lys Ala Phe 
        115                 120                 125             


Arg Lys Pro Ser Ile Phe Thr Leu His Lys Lys Thr Asp Ile Gly Glu 
    130                 135                 140                 


Glu Leu Pro Asn Cys Asn Gln Cys Glu Thr Ala Phe Ser Gln His Leu 
145                 150                 155                 160 


His Leu Val Cys Lys Lys Thr Ser Gln Asn Leu His Leu Val Cys Lys 
                165                 170                 175     


Lys Thr His Thr Gln Glu Lys Pro Tyr Lys Cys Ser Asp Cys Glu Lys 
            180                 185                 190         


Gly Leu Pro Ser Ser Ser His Leu Arg Glu Cys Val Arg Ile Tyr Gly 
        195                 200                 205             


Gly Glu Arg Pro Tyr Thr His Lys Glu Tyr Val Glu Thr Phe Ser His 
    210                 215                 220                 


Ser Thr Ala Leu Phe Val His Met Gln Thr Gln Asp Gly Glu Lys Phe 
225                 230                 235                 240 


Tyr Glu Cys Lys Ala Cys Gly Lys Pro Phe Thr Glu Ser Ser Tyr Leu 
                245                 250                 255     


Thr Gln His Leu Arg Thr His Ser Arg Val Leu Pro Ile Glu His Lys 
            260                 265                 270         


Lys Phe Gly Lys Ala Phe Ala Phe Ser Pro Asp Leu Ala Lys His Ile 
        275                 280                 285             


Arg Leu Arg Thr Arg Gly Lys His Tyr Val Cys Asn Glu Cys Gly Lys 
    290                 295                 300                 


Glu Phe Thr Cys Phe Ser Lys Leu Asn Ile His Ile Arg Val His Thr 
305                 310                 315                 320 


Gly Glu Lys Pro Tyr Glu Cys Asn Lys Cys Gly Lys Ala Phe Thr Asp 
                325                 330                 335     


Ser Ser Gly Leu Ile Lys His Arg Arg Thr His Thr Gly Glu Lys Pro 
            340                 345                 350         


Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Ala Asn Ser Ser His Leu 
        355                 360                 365             


Thr Val His Met Arg Thr His Thr Gly Glu Lys Pro Tyr Gln Cys Lys 
    370                 375                 380                 


Glu Cys Gly Lys Ala Phe Ile Asn Ser Ser Ser Phe Lys Ser His Met 
385                 390                 395                 400 


Gln Thr His Pro Gly Val Lys Pro Tyr Asp Cys Gln Gln Cys Gly Lys 
                405                 410                 415     


Ala Phe Ile Arg Ser Ser Phe Leu Ile Arg His Leu Arg Ser His Ser 
            420                 425                 430         


Ala Glu Arg Pro Phe Glu Cys Glu Glu Cys Gly Lys Ala Phe Arg Tyr 
        435                 440                 445             


Ser Ser His Leu Ser Gln His Lys Arg Ile His Thr Gly Glu Arg Pro 
    450                 455                 460                 


Tyr Lys Cys Gln Lys Cys Gly Gln Ala Phe Ser Ile Ser Ser Gly Leu 
465                 470                 475                 480 


Thr Val His Met Arg Thr His Thr Gly Glu Arg Pro Phe Glu Cys Gln 
                485                 490                 495     


Glu Cys Gly Lys Ala Phe Thr Arg Ser Thr Tyr Leu Ile Arg His Leu 
            500                 505                 510         


Arg Ser His Ser Val Glu Lys Pro Tyr Lys Glu Cys Gly Gln Thr Phe 
        515                 520                 525             


Ser Asn Ser Ser Cys Leu Thr Glu Cys Val 
    530                 535             


<210>  5362
<211>  689
<212>  PRT
<213>  Homo sapiens

<400>  5362

Met Ala Ala Arg Thr Leu Gly Arg Gly Val Gly Arg Leu Leu Gly Ser 
1               5                   10                  15      


Leu Arg Gly Leu Ser Gly Gln Pro Ala Arg Pro Pro Cys Gly Val Ser 
            20                  25                  30          


Ala Pro Arg Arg Ala Ala Ser Gly Pro Ser Gly Ser Ala Pro Ala Val 
        35                  40                  45              


Ala Ala Ala Ala Ala Gln Pro Gly Ser Tyr Pro Ala Leu Ser Ala Gln 
    50                  55                  60                  


Ala Ala Arg Glu Pro Ala Ala Phe Trp Gly Pro Leu Ala Arg Asp Thr 
65                  70                  75                  80  


Leu Val Trp Asp Thr Pro Tyr His Thr Val Trp Asp Cys Asp Phe Ser 
                85                  90                  95      


Thr Gly Lys Ile Gly Trp Phe Leu Gly Gly Gln Leu Asn Val Ser Val 
            100                 105                 110         


Asn Cys Leu Asp Gln His Val Arg Lys Ser Pro Glu Ser Val Ala Leu 
        115                 120                 125             


Ile Trp Glu Arg Asp Glu Pro Gly Thr Glu Val Arg Ile Thr Tyr Arg 
    130                 135                 140                 


Glu Leu Leu Glu Thr Thr Cys Arg Leu Ala Asn Thr Leu Lys Arg His 
145                 150                 155                 160 


Gly Val His Arg Gly Asp Arg Val Ala Ile Tyr Met Pro Val Ser Pro 
                165                 170                 175     


Leu Ala Val Ala Ala Met Leu Ala Cys Ala Arg Ile Gly Ala Val His 
            180                 185                 190         


Thr Val Ile Phe Ala Gly Phe Ser Ala Glu Ser Leu Ala Gly Arg Ile 
        195                 200                 205             


Asn Asp Ala Lys Cys Lys Val Val Ile Thr Phe Asn Gln Gly Leu Arg 
    210                 215                 220                 


Gly Gly Arg Val Val Glu Leu Lys Lys Ile Val Asp Glu Ala Val Lys 
225                 230                 235                 240 


His Cys Pro Thr Val Gln His Val Leu Val Ala His Arg Thr Asp Asn 
                245                 250                 255     


Lys Val His Met Gly Asp Leu Asp Val Pro Leu Glu Gln Glu Met Ala 
            260                 265                 270         


Lys Glu Asp Pro Val Cys Ala Pro Glu Ser Met Gly Ser Glu Asp Met 
        275                 280                 285             


Leu Phe Met Leu Tyr Thr Ser Gly Ser Thr Gly Met Pro Lys Gly Ile 
    290                 295                 300                 


Val His Thr Gln Ala Gly Tyr Leu Leu Tyr Ala Ala Leu Thr His Lys 
305                 310                 315                 320 


Leu Val Phe Asp His Gln Pro Gly Asp Ile Phe Gly Cys Val Ala Asp 
                325                 330                 335     


Ile Gly Trp Ile Thr Gly His Ser Tyr Val Val Tyr Gly Pro Leu Cys 
            340                 345                 350         


Asn Gly Ala Thr Ser Val Leu Phe Glu Ser Thr Pro Val Tyr Pro Asn 
        355                 360                 365             


Ala Gly Arg Tyr Trp Glu Thr Val Glu Arg Leu Lys Ile Asn Gln Phe 
    370                 375                 380                 


Tyr Gly Ala Pro Thr Ala Val Arg Leu Leu Leu Lys Tyr Gly Asp Ala 
385                 390                 395                 400 


Trp Val Lys Lys Tyr Asp Arg Ser Ser Leu Arg Thr Leu Gly Ser Val 
                405                 410                 415     


Gly Glu Pro Ile Asn Cys Glu Ala Trp Glu Trp Leu His Arg Val Val 
            420                 425                 430         


Gly Asp Ser Arg Cys Thr Leu Val Asp Thr Trp Trp Gln Thr Glu Thr 
        435                 440                 445             


Gly Gly Ile Cys Ile Ala Pro Arg Pro Ser Glu Glu Gly Ala Glu Ile 
    450                 455                 460                 


Leu Pro Ala Met Ala Met Arg Pro Phe Phe Gly Ile Val Pro Val Leu 
465                 470                 475                 480 


Met Asp Glu Lys Gly Ser Val Val Glu Gly Ser Asn Val Ser Gly Ala 
                485                 490                 495     


Leu Cys Ile Ser Gln Ala Trp Pro Gly Met Ala Arg Thr Ile Tyr Gly 
            500                 505                 510         


Asp His Gln Arg Phe Val Asp Ala Tyr Phe Lys Ala Tyr Pro Gly Tyr 
        515                 520                 525             


Tyr Phe Thr Gly Asp Gly Ala Tyr Arg Thr Glu Gly Gly Tyr Tyr Gln 
    530                 535                 540                 


Ile Thr Gly Arg Met Asp Asp Val Ile Asn Ile Ser Gly His Arg Leu 
545                 550                 555                 560 


Gly Thr Ala Glu Ile Glu Asp Ala Ile Ala Asp His Pro Ala Val Pro 
                565                 570                 575     


Glu Ser Ala Val Ile Gly Tyr Pro His Asp Ile Lys Gly Glu Ala Ala 
            580                 585                 590         


Phe Ala Phe Ile Val Val Lys Asp Ser Ala Gly Asp Ser Asp Val Val 
        595                 600                 605             


Val Gln Glu Leu Lys Ser Met Val Ala Thr Lys Ile Ala Lys Tyr Ala 
    610                 615                 620                 


Val Pro Asp Glu Ile Leu Val Val Lys Arg Leu Pro Lys Thr Arg Ser 
625                 630                 635                 640 


Gly Lys Val Met Arg Arg Leu Leu Arg Lys Ile Ile Thr Ser Glu Ala 
                645                 650                 655     


Gln Glu Leu Gly Asp Thr Thr Thr Leu Glu Asp Pro Ser Ile Ile Ala 
            660                 665                 670         


Glu Ile Leu Ser Val Tyr Gln Lys Cys Lys Asp Lys Gln Ala Ala Ala 
        675                 680                 685             


Lys 
    


<210>  5363
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  5363

Met Asn Pro Phe His Ala Ser Cys Trp Asn Thr Ser Ala Glu Leu Leu 
1               5                   10                  15      


Asn Lys Ser Trp Asn Lys Glu Phe Ala Tyr Gln Thr Ala Ser Val Val 
            20                  25                  30          


Asp Thr Val Ile Leu Pro Ser Met Ile Gly Ile Ile Cys Ser Thr Gly 
        35                  40                  45              


Leu Val Gly Asn Ile Leu Ile Val Phe Thr Ile Ile Arg Ser Arg Lys 
    50                  55                  60                  


Lys Thr Val Pro Asp Ile Tyr Ile Cys Asn Leu Ala Val Ala Asp Leu 
65                  70                  75                  80  


Val His Ile Val Gly Met Pro Phe Leu Ile His Gln Trp Ala Arg Gly 
                85                  90                  95      


Gly Glu Trp Val Phe Gly Gly Pro Leu Cys Thr Ile Ile Thr Ser Leu 
            100                 105                 110         


Asp Thr Cys Asn Gln Phe Ala Cys Ser Ala Ile Met Thr Val Met Ser 
        115                 120                 125             


Val Asp Arg Tyr Phe Ala Leu Val Gln Pro Phe Arg Leu Thr Arg Trp 
    130                 135                 140                 


Arg Thr Arg Tyr Lys Thr Ile Arg Ile Asn Leu Gly Leu Trp Ala Ala 
145                 150                 155                 160 


Ser Phe Ile Leu Ala Leu Pro Val Trp Val Tyr Ser Lys Val Ile Lys 
                165                 170                 175     


Phe Lys Asp Gly Val Glu Ser Cys Ala Phe Asp Leu Thr Ser Pro Asp 
            180                 185                 190         


Asp Val Leu Trp Tyr Thr Leu Tyr Leu Thr Ile Thr Thr Phe Phe Phe 
        195                 200                 205             


Pro Leu Pro Leu Ile Leu Val Cys Tyr Ile Leu Ile Leu Cys Tyr Thr 
    210                 215                 220                 


Trp Glu Met Tyr Gln Gln Asn Lys Asp Ala Arg Cys Cys Asn Pro Ser 
225                 230                 235                 240 


Val Pro Lys Gln Arg Val Met Lys Leu Thr Lys Met Val Leu Val Leu 
                245                 250                 255     


Val Val Val Phe Ile Leu Ser Ala Ala Pro Tyr His Val Ile Gln Leu 
            260                 265                 270         


Val Asn Leu Gln Met Glu Gln Pro Thr Leu Ala Phe Tyr Val Gly Tyr 
        275                 280                 285             


Tyr Leu Ser Ile Cys Leu Ser Tyr Ala Ser Ser Ser Ile Asn Pro Phe 
    290                 295                 300                 


Leu Tyr Ile Leu Leu Ser Gly Asn Phe Gln Lys Arg Leu Pro Gln Ile 
305                 310                 315                 320 


Gln Arg Arg Ala Thr Glu Lys Glu Ile Asn Asn Met Gly Asn Thr Leu 
                325                 330                 335     


Lys Ser His Phe 
            340 


<210>  5364
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  5364

Met Glu Ala Lys Glu Lys Gln His Leu Leu Asp Ala Arg Pro Ala Ile 
1               5                   10                  15      


Arg Ser Tyr Thr Gly Ser Leu Trp Gln Glu Gly Ala Gly Trp Ile Pro 
            20                  25                  30          


Leu Pro Arg Pro Gly Leu Asp Leu Gln Ala Ile Glu Leu Ala Ala Gln 
        35                  40                  45              


Ser Asn His His Cys His Ala Gln Lys Gly Pro Asp Ser His Cys Asp 
    50                  55                  60                  


Pro Lys Lys Gly Lys Ala Gln Arg Gln Leu Tyr Val Ala Ser Ala Ile 
65                  70                  75                  80  


Cys Leu Leu Phe Met Ile Gly Glu Val Val Glu Ile Leu Gly Ala Leu 
                85                  90                  95      


Val Ser Val Leu Ser Ile Trp Val Val Thr Gly Val Leu Val Tyr Leu 
            100                 105                 110         


Ala Val Glu Arg Leu Ile Ser Gly Asp Tyr Glu Ile Asp Gly Gly Thr 
        115                 120                 125             


Met Leu Ile Thr Ser Gly Cys Ala Val Ala Val Asn Ile Ile Met Gly 
    130                 135                 140                 


Leu Thr Leu His Gln Ser Gly His Gly His Ser His Gly Thr Thr Asn 
145                 150                 155                 160 


Gln Gln Glu Glu Asn Pro Ser Val Arg Ala Ala Phe Ile His Val Ile 
                165                 170                 175     


Gly Asp Phe Met Gln Ser Met Gly Val Leu Val Ala Ala Tyr Ile Leu 
            180                 185                 190         


Tyr Phe Lys Pro Glu Tyr Lys Tyr Val Asp Pro Ile Cys Thr Phe Val 
        195                 200                 205             


Phe Ser Ile Leu Val Leu Gly Thr Thr Leu Thr Ile Leu Arg Asp Val 
    210                 215                 220                 


Ile Leu Val Leu Met Glu Gly Thr Pro Lys Gly Val Asp Phe Thr Ala 
225                 230                 235                 240 


Val Arg Asp Leu Leu Leu Ser Val Glu Gly Val Glu Ala Leu His Ser 
                245                 250                 255     


Leu His Ile Trp Ala Leu Thr Val Ala Gln Pro Val Leu Ser Val His 
            260                 265                 270         


Ile Ala Ile Ala Gln Asn Thr Asp Ala Gln Ala Val Leu Lys Thr Ala 
        275                 280                 285             


Ser Ser Arg Leu Gln Gly Lys Phe His Phe His Thr Val Thr Ile Gln 
    290                 295                 300                 


Ile Glu Asp Tyr Ser Glu Asp Met Lys Asp Cys Gln Ala Cys Gln Gly 
305                 310                 315                 320 


Pro Ser Asp 
            


<210>  5365
<211>  642
<212>  PRT
<213>  Homo sapiens

<400>  5365

Met Leu Leu Lys Lys His Ala Gly Lys Gly Gly Gly Arg Glu Pro Arg 
1               5                   10                  15      


Ser Glu Asp Pro Thr Pro Ala Glu Gln His Cys Ala Arg Thr Met Pro 
            20                  25                  30          


Pro Cys Ala Val Leu Ala Ala Leu Leu Ser Val Val Ala Val Val Ser 
        35                  40                  45              


Cys Leu Tyr Leu Gly Val Lys Thr Asn Asp Leu Gln Ala Arg Ile Ala 
    50                  55                  60                  


Ala Leu Glu Ser Ala Lys Gly Ala Pro Ser Ile His Leu Leu Pro Asp 
65                  70                  75                  80  


Thr Leu Asp His Leu Lys Thr Met Val Gln Glu Lys Val Glu Arg Leu 
                85                  90                  95      


Leu Ala Gln Lys Ser Tyr Glu His Met Ala Lys Ile Arg Ile Ala Arg 
            100                 105                 110         


Glu Ala Pro Ser Glu Cys Asn Cys Pro Ala Gly Pro Pro Gly Lys Arg 
        115                 120                 125             


Gly Lys Arg Gly Arg Arg Gly Glu Ser Gly Pro Pro Gly Gln Pro Gly 
    130                 135                 140                 


Pro Gln Gly Pro Pro Gly Pro Lys Gly Asp Lys Gly Glu Gln Gly Asp 
145                 150                 155                 160 


Gln Gly Pro Arg Met Val Phe Pro Lys Ile Asn His Gly Phe Leu Ser 
                165                 170                 175     


Ala Asp Gln Gln Leu Ile Lys Arg Arg Leu Ile Lys Gly Asp Gln Gly 
            180                 185                 190         


Gln Ala Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Pro 
        195                 200                 205             


Pro Gly Asp Thr Gly Lys Asp Gly Pro Arg Gly Met Pro Gly Val Pro 
    210                 215                 220                 


Gly Glu Pro Gly Lys Pro Gly Glu Gln Gly Leu Met Gly Pro Leu Gly 
225                 230                 235                 240 


Pro Pro Gly Gln Lys Gly Ser Ile Gly Ala Pro Gly Ile Pro Gly Met 
                245                 250                 255     


Asn Gly Gln Lys Gly Glu Pro Gly Leu Pro Gly Ala Val Gly Gln Asn 
            260                 265                 270         


Gly Ile Pro Gly Pro Lys Gly Glu Pro Gly Glu Gln Gly Glu Lys Gly 
        275                 280                 285             


Asp Ala Gly Glu Asn Gly Pro Lys Gly Asp Thr Gly Glu Lys Gly Asp 
    290                 295                 300                 


Pro Gly Ser Ser Ala Ala Gly Ile Lys Gly Glu Pro Gly Glu Ser Gly 
305                 310                 315                 320 


Arg Pro Gly Gln Lys Gly Glu Pro Gly Leu Pro Gly Leu Pro Gly Leu 
                325                 330                 335     


Pro Gly Ile Lys Gly Glu Pro Gly Phe Ile Gly Pro Gln Gly Glu Pro 
            340                 345                 350         


Gly Leu Pro Gly Leu Pro Gly Thr Lys Gly Glu Arg Gly Glu Ala Gly 
        355                 360                 365             


Pro Pro Gly Arg Gly Glu Arg Gly Glu Pro Gly Ala Pro Gly Pro Lys 
    370                 375                 380                 


Gly Lys Gln Gly Glu Ser Gly Thr Arg Gly Pro Lys Gly Ser Lys Gly 
385                 390                 395                 400 


Asp Arg Gly Glu Lys Gly Asp Ser Gly Ala Gln Gly Pro Arg Gly Pro 
                405                 410                 415     


Pro Gly Gln Lys Gly Asp Gln Gly Ala Thr Glu Ile Ile Asp Tyr Asn 
            420                 425                 430         


Gly Asn Leu His Glu Ala Leu Gln Arg Ile Thr Thr Leu Thr Val Thr 
        435                 440                 445             


Gly Pro Pro Gly Pro Pro Gly Pro Gln Gly Leu Gln Gly Pro Lys Gly 
    450                 455                 460                 


Glu Gln Gly Ser Pro Gly Ile Pro Gly Met Asp Gly Glu Gln Gly Leu 
465                 470                 475                 480 


Lys Gly Ser Lys Gly Asp Met Gly Asp Pro Gly Met Thr Gly Glu Lys 
                485                 490                 495     


Gly Gly Ile Gly Leu Pro Gly Leu Pro Gly Ala Asn Gly Met Lys Gly 
            500                 505                 510         


Glu Lys Gly Asp Ser Gly Met Pro Gly Pro Gln Gly Pro Ser Ile Ile 
        515                 520                 525             


Gly Pro Pro Gly Pro Pro Gly Pro His Gly Pro Pro Gly Pro Met Gly 
    530                 535                 540                 


Pro His Gly Leu Pro Gly Pro Lys Gly Thr Asp Gly Pro Met Gly Pro 
545                 550                 555                 560 


His Gly Pro Ala Gly Pro Lys Gly Glu Arg Gly Glu Lys Gly Ala Met 
                565                 570                 575     


Gly Glu Pro Gly Pro Arg Gly Pro Tyr Gly Leu Pro Gly Lys Asp Gly 
            580                 585                 590         


Glu Pro Gly Leu Asp Gly Phe Pro Gly Pro Arg Gly Glu Lys Gly Asp 
        595                 600                 605             


Leu Gly Glu Lys Gly Glu Lys Val Thr Ser Pro Ser Gln His Val Pro 
    610                 615                 620                 


Cys Leu Ile Leu Leu Leu Leu Ser Ala Leu Leu Phe Ser Leu Cys Asp 
625                 630                 635                 640 


Ser Ile 
        


<210>  5366
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  5366

Met Lys Pro His Leu Lys Gln Trp Arg Gln Arg Met Leu Phe Gly Ile 
1               5                   10                  15      


Phe Ala Trp Gly Leu Leu Phe Leu Leu Ile Phe Ile Tyr Phe Thr Asp 
            20                  25                  30          


Ser Asn Pro Ala Glu Pro Val Pro Ser Ser Leu Ser Phe Leu Glu Thr 
        35                  40                  45              


Arg Arg Leu Leu Pro Val Gln Gly Lys Gln Arg Ala Ile Met Gly Ala 
    50                  55                  60                  


Ala His Glu Pro Ser Pro Pro Gly Gly Leu Asp Ala Arg Gln Ala Leu 
65                  70                  75                  80  


Pro Arg Ala His Pro Ala Gly Ser Phe His Ala Gly Pro Gly Asp Leu 
                85                  90                  95      


Gln Lys Trp Ala Gln Ser Gln Asp Gly Phe Glu His Lys Glu Phe Phe 
            100                 105                 110         


Ser Ser Gln Val Gly Arg Lys Ser Gln Ser Ala Phe Tyr Pro Glu Asp 
        115                 120                 125             


Asp Asp Tyr Phe Phe Ala Ala Gly Gln Pro Gly Trp His Ser His Thr 
    130                 135                 140                 


Gln Gly Thr Leu Gly Phe Pro Ser Pro Gly Glu Pro Gly Pro Arg Glu 
145                 150                 155                 160 


Gly Ala Phe Pro Ala Ala Gln Val Gln Arg Arg Arg Val Lys Lys Arg 
                165                 170                 175     


His Arg Arg Gln Arg Arg Ser His Val Leu Glu Glu Gly Asp Asp Gly 
            180                 185                 190         


Asp Arg Leu Tyr Ser Ser Met Ser Arg Ala Phe Leu Tyr Arg Leu Trp 
        195                 200                 205             


Lys Gly Asn Val Ser Ser Lys Met Leu Asn Pro Arg Leu Gln Lys Ala 
    210                 215                 220                 


Met Lys Asp Tyr Leu Thr Ala Asn Lys His Gly Val Arg Phe Arg Gly 
225                 230                 235                 240 


Lys Arg Glu Ala Gly Leu Ser Arg Ala Gln Leu Leu Cys Gln Leu Arg 
                245                 250                 255     


Ser Arg Ala Arg Val Arg Thr Leu Asp Gly Thr Glu Ala Pro Phe Ser 
            260                 265                 270         


Ala Leu Gly Trp Arg Arg Leu Val Pro Ala Val Pro Leu Ser Gln Leu 
        275                 280                 285             


His Pro Arg Gly Leu Arg Ser Cys Ala Val Val Met Ser Ala Gly Ala 
    290                 295                 300                 


Ile Leu Asn Ser Ser Leu Gly Glu Glu Ile Asp Ser His Asp Ala Val 
305                 310                 315                 320 


Leu Arg Phe Asn Ser Ala Pro Thr Arg Gly Tyr Glu Lys Asp Val Gly 
                325                 330                 335     


Asn Lys Thr Thr Ile Arg Ile Ile Asn Ser Gln Ile Leu Thr Asn Pro 
            340                 345                 350         


Ser His His Phe Ile Asp Ser Ser Leu Tyr Lys Asp Val Ile Leu Val 
        355                 360                 365             


Ala Trp Asp Pro Ala Pro Tyr Ser Ala Asn Leu Asn Leu Trp Tyr Lys 
    370                 375                 380                 


Lys Pro Asp Tyr Asn Leu Phe Thr Pro Tyr Ile Gln His Arg Gln Arg 
385                 390                 395                 400 


Asn Pro Asn Gln Pro Phe Tyr Ile Leu His Pro Lys Phe Ile Trp Gln 
                405                 410                 415     


Leu Trp Asp Ile Ile Gln Glu Asn Thr Lys Glu Lys Ile Gln Pro Asn 
            420                 425                 430         


Pro Pro Ser Ser Gly Phe Ile Gly Ile Leu Ile Met Met Ser Met Cys 
        435                 440                 445             


Arg Glu Val His Val Tyr Glu Tyr Ile Pro Ser Val Arg Gln Thr Glu 
    450                 455                 460                 


Leu Cys His Tyr His Glu Leu Tyr Tyr Asp Ala Ala Cys Thr Leu Gly 
465                 470                 475                 480 


Ala Tyr His Pro Leu Leu Tyr Glu Lys Leu Leu Val Gln Arg Leu Asn 
                485                 490                 495     


Met Gly Thr Gln Gly Asp Leu His Arg Lys Gly Lys Val Val Leu Pro 
            500                 505                 510         


Gly Phe Gln Ala Val His Cys Pro Ala Pro Ser Pro Val Ile Pro His 
        515                 520                 525             


Ser 
    


<210>  5367
<211>  778
<212>  PRT
<213>  Homo sapiens

<400>  5367

Met Lys Pro Phe Gln Leu Asp Leu Leu Phe Val Cys Phe Phe Leu Phe 
1               5                   10                  15      


Ser Gln Glu Leu Gly Leu Gln Lys Arg Gly Cys Cys Leu Val Leu Gly 
            20                  25                  30          


Tyr Met Ala Lys Asp Lys Phe Arg Arg Met Asn Glu Gly Gln Val Tyr 
        35                  40                  45              


Ser Phe Ser Gln Gln Pro Gln Asp Gln Val Val Val Ser Gly Gln Pro 
    50                  55                  60                  


Val Thr Leu Leu Cys Ala Ile Pro Glu Tyr Asp Gly Phe Val Leu Trp 
65                  70                  75                  80  


Ile Lys Asp Gly Leu Ala Leu Gly Val Gly Arg Asp Leu Ser Ser Tyr 
                85                  90                  95      


Pro Gln Tyr Leu Val Val Gly Asn His Leu Ser Gly Glu His His Leu 
            100                 105                 110         


Lys Ile Leu Arg Ala Glu Leu Gln Asp Asp Ala Val Tyr Glu Cys Gln 
        115                 120                 125             


Ala Ile Gln Ala Ala Ile Arg Ser Arg Pro Ala Arg Leu Thr Val Leu 
    130                 135                 140                 


Val Pro Pro Asp Asp Pro Val Ile Leu Gly Gly Pro Val Ile Ser Leu 
145                 150                 155                 160 


Arg Ala Gly Asp Pro Leu Asn Leu Thr Cys His Ala Asp Asn Ala Lys 
                165                 170                 175     


Pro Ala Ala Ser Ile Ile Trp Leu Arg Lys Gly Glu Val Ile Asn Gly 
            180                 185                 190         


Ala Thr Tyr Ser Lys Thr Leu Leu Arg Asp Gly Lys Arg Glu Ser Ile 
        195                 200                 205             


Val Ser Thr Leu Phe Ile Ser Pro Gly Asp Val Glu Asn Gly Gln Ser 
    210                 215                 220                 


Ile Val Cys Arg Ala Thr Asn Lys Ala Ile Pro Gly Gly Lys Glu Thr 
225                 230                 235                 240 


Ser Val Thr Ile Asp Ile Gln His Pro Pro Leu Val Asn Leu Ser Val 
                245                 250                 255     


Glu Pro Gln Pro Val Leu Glu Asp Asn Val Val Thr Phe His Cys Ser 
            260                 265                 270         


Ala Lys Ala Asn Pro Ala Val Thr Gln Tyr Arg Trp Ala Lys Arg Gly 
        275                 280                 285             


Gln Ile Ile Lys Glu Ala Ser Gly Glu Val Tyr Arg Thr Thr Val Asp 
    290                 295                 300                 


Tyr Thr Tyr Phe Ser Glu Pro Val Ser Cys Glu Val Thr Asn Ala Leu 
305                 310                 315                 320 


Gly Ser Thr Asn Leu Ser Arg Thr Val Asp Val Tyr Phe Gly Pro Arg 
                325                 330                 335     


Met Thr Thr Glu Pro Gln Ser Leu Leu Val Asp Leu Gly Ser Asp Ala 
            340                 345                 350         


Ile Phe Ser Cys Ala Trp Thr Gly Asn Pro Ser Leu Thr Ile Val Trp 
        355                 360                 365             


Met Lys Arg Gly Ser Gly Val Val Leu Ser Asn Glu Lys Thr Leu Thr 
    370                 375                 380                 


Leu Lys Ser Val Arg Gln Glu Asp Ala Gly Lys Tyr Val Cys Arg Ala 
385                 390                 395                 400 


Val Val Pro Arg Val Gly Ala Gly Glu Arg Glu Val Thr Leu Thr Val 
                405                 410                 415     


Asn Gly Pro Pro Ile Ile Ser Ser Thr Gln Thr Gln His Ala Leu His 
            420                 425                 430         


Gly Glu Lys Gly Gln Ile Lys Cys Phe Ile Arg Ser Thr Pro Pro Pro 
        435                 440                 445             


Asp Arg Ile Ala Trp Ser Trp Lys Glu Asn Val Leu Glu Ser Gly Thr 
    450                 455                 460                 


Ser Gly Arg Tyr Thr Val Glu Thr Ile Ser Thr Glu Glu Gly Val Ile 
465                 470                 475                 480 


Ser Thr Leu Thr Ile Ser Asn Ile Val Arg Ala Asp Phe Gln Thr Ile 
                485                 490                 495     


Tyr Asn Cys Thr Ala Trp Asn Ser Phe Gly Ser Asp Thr Glu Ile Ile 
            500                 505                 510         


Arg Leu Lys Glu Gln Gly Ser Glu Met Lys Ser Gly Ala Gly Leu Glu 
        515                 520                 525             


Ala Glu Ser Val Pro Met Ala Val Ile Ile Gly Val Ala Val Gly Ala 
    530                 535                 540                 


Gly Val Ala Phe Leu Val Leu Met Ala Thr Ile Val Ala Phe Cys Cys 
545                 550                 555                 560 


Ala Arg Ser Gln Arg Asn Leu Lys Gly Val Val Ser Ala Lys Asn Asp 
                565                 570                 575     


Ile Arg Val Glu Ile Val His Lys Glu Pro Ala Ser Gly Arg Glu Gly 
            580                 585                 590         


Glu Glu His Ser Thr Ile Lys Gln Leu Met Met Asp Arg Gly Glu Phe 
        595                 600                 605             


Gln Gln Asp Ser Val Leu Lys Gln Leu Glu Val Leu Lys Glu Glu Glu 
    610                 615                 620                 


Lys Glu Phe Gln Asn Leu Lys Asp Pro Thr Asn Gly Tyr Tyr Ser Val 
625                 630                 635                 640 


Asn Thr Phe Lys Glu His His Ser Thr Pro Thr Ile Ser Leu Ser Ser 
                645                 650                 655     


Cys Gln Pro Asp Leu Arg Pro Ala Gly Lys Gln Arg Val Pro Thr Gly 
            660                 665                 670         


Met Ser Phe Thr Asn Ile Tyr Ser Thr Leu Ser Gly Gln Gly Arg Leu 
        675                 680                 685             


Tyr Asp Tyr Gly Gln Arg Phe Val Leu Gly Met Gly Ser Ser Ser Ile 
    690                 695                 700                 


Glu Leu Cys Glu Arg Glu Phe Gln Arg Gly Ser Leu Ser Asp Ser Ser 
705                 710                 715                 720 


Ser Phe Leu Asp Thr Gln Cys Asp Ser Ser Val Ser Ser Ser Gly Lys 
                725                 730                 735     


Gln Asp Gly Tyr Val Gln Phe Asp Lys Ala Ser Lys Ala Ser Ala Ser 
            740                 745                 750         


Ser Ser His His Ser Gln Ser Ser Ser Gln Asn Ser Asp Pro Ser Arg 
        755                 760                 765             


Pro Leu Gln Arg Arg Met Gln Thr His Val 
    770                 775             


<210>  5368
<211>  845
<212>  PRT
<213>  Homo sapiens

<400>  5368

Met Leu Ser Gly Val Trp Phe Leu Ser Val Leu Thr Val Ala Gly Ile 
1               5                   10                  15      


Leu Gln Thr Glu Ser Arg Lys Thr Ala Lys Asp Ile Cys Lys Ile Arg 
            20                  25                  30          


Cys Leu Cys Glu Glu Lys Glu Asn Val Leu Asn Ile Asn Cys Glu Asn 
        35                  40                  45              


Lys Gly Phe Thr Thr Val Ser Leu Leu Gln Pro Pro Gln Tyr Arg Ile 
    50                  55                  60                  


Tyr Gln Leu Phe Leu Asn Gly Asn Leu Leu Thr Arg Leu Tyr Pro Asn 
65                  70                  75                  80  


Glu Phe Val Asn Tyr Ser Asn Ala Val Thr Leu His Leu Gly Asn Asn 
                85                  90                  95      


Gly Leu Gln Glu Ile Arg Thr Gly Ala Phe Ser Gly Leu Lys Thr Leu 
            100                 105                 110         


Lys Arg Leu His Leu Asn Asn Asn Lys Leu Glu Ile Leu Arg Glu Asp 
        115                 120                 125             


Thr Phe Leu Gly Leu Glu Ser Leu Glu Tyr Leu Gln Ala Asp Tyr Asn 
    130                 135                 140                 


Tyr Ile Ser Ala Ile Glu Ala Gly Ala Phe Ser Lys Leu Asn Lys Leu 
145                 150                 155                 160 


Lys Val Leu Ile Leu Asn Asp Asn Leu Leu Leu Ser Leu Pro Ser Asn 
                165                 170                 175     


Val Phe Arg Phe Val Leu Leu Thr His Leu Asp Leu Arg Gly Asn Arg 
            180                 185                 190         


Leu Lys Val Met Pro Phe Ala Gly Val Leu Glu His Ile Gly Gly Ile 
        195                 200                 205             


Met Glu Ile Gln Leu Glu Glu Asn Pro Trp Asn Cys Thr Cys Asp Leu 
    210                 215                 220                 


Leu Pro Leu Lys Ala Trp Leu Asp Thr Ile Thr Val Phe Val Gly Glu 
225                 230                 235                 240 


Ile Val Cys Glu Thr Pro Phe Arg Leu His Gly Lys Asp Val Thr Gln 
                245                 250                 255     


Leu Thr Arg Gln Asp Leu Cys Pro Arg Lys Ser Ala Ser Asp Ser Ser 
            260                 265                 270         


Gln Arg Gly Ser His Ala Asp Thr His Val Gln Arg Leu Ser Pro Thr 
        275                 280                 285             


Met Asn Pro Ala Leu Asn Pro Thr Arg Ala Pro Lys Ala Ser Arg Pro 
    290                 295                 300                 


Pro Lys Met Arg Asn Arg Pro Thr Pro Arg Val Thr Val Ser Lys Asp 
305                 310                 315                 320 


Arg Gln Ser Phe Gly Pro Ile Met Val Tyr Gln Thr Lys Ser Pro Val 
                325                 330                 335     


Pro Leu Thr Cys Pro Ser Ser Cys Val Cys Thr Ser Gln Ser Ser Asp 
            340                 345                 350         


Asn Gly Leu Asn Val Asn Cys Gln Glu Arg Lys Phe Thr Asn Ile Ser 
        355                 360                 365             


Asp Leu Gln Pro Lys Pro Thr Ser Pro Lys Lys Leu Tyr Leu Thr Gly 
    370                 375                 380                 


Asn Tyr Leu Gln Thr Val Tyr Lys Asn Asp Leu Leu Glu Tyr Ser Ser 
385                 390                 395                 400 


Leu Asp Leu Leu His Leu Gly Asn Asn Arg Ile Ala Val Ile Gln Glu 
                405                 410                 415     


Gly Ala Phe Thr Asn Leu Thr Ser Leu Arg Arg Leu Tyr Leu Asn Gly 
            420                 425                 430         


Asn Tyr Leu Glu Val Leu Tyr Pro Ser Met Phe Asp Gly Leu Gln Ser 
        435                 440                 445             


Leu Gln Tyr Leu Tyr Leu Glu Tyr Asn Val Ile Lys Glu Ile Lys Pro 
    450                 455                 460                 


Leu Thr Phe Asp Ala Leu Ile Asn Leu Gln Leu Leu Phe Leu Asn Asn 
465                 470                 475                 480 


Asn Leu Leu Arg Ser Leu Pro Asp Asn Ile Phe Gly Gly Thr Ala Leu 
                485                 490                 495     


Thr Arg Leu Asn Leu Arg Asn Asn His Phe Ser His Leu Pro Val Lys 
            500                 505                 510         


Gly Val Leu Asp Gln Leu Pro Ala Phe Ile Gln Ile Asp Leu Gln Glu 
        515                 520                 525             


Asn Pro Trp Asp Cys Thr Cys Asp Ile Met Gly Leu Lys Asp Trp Thr 
    530                 535                 540                 


Glu His Ala Asn Ser Pro Val Ile Ile Asn Glu Val Thr Cys Glu Ser 
545                 550                 555                 560 


Pro Ala Lys His Ala Gly Glu Ile Leu Lys Phe Leu Gly Arg Glu Ala 
                565                 570                 575     


Ile Cys Pro Asp Ser Pro Asn Leu Ser Asp Gly Thr Val Leu Ser Met 
            580                 585                 590         


Asn His Asn Thr Asp Thr Pro Arg Ser Leu Ser Val Ser Pro Ser Ser 
        595                 600                 605             


Tyr Pro Glu Leu His Thr Glu Val Pro Leu Ser Val Leu Ile Leu Gly 
    610                 615                 620                 


Leu Leu Val Val Phe Ile Leu Ser Val Cys Phe Gly Ala Gly Leu Phe 
625                 630                 635                 640 


Val Phe Val Leu Lys Arg Arg Lys Gly Val Pro Ser Val Pro Arg Asn 
                645                 650                 655     


Thr Asn Asn Leu Asp Val Ser Ser Phe Gln Leu Gln Tyr Gly Ser Tyr 
            660                 665                 670         


Asn Thr Glu Thr His Asp Lys Thr Asp Gly His Val Tyr Asn Tyr Ile 
        675                 680                 685             


Pro Pro Pro Val Gly Gln Met Cys Gln Asn Pro Ile Tyr Met Gln Lys 
    690                 695                 700                 


Glu Gly Asp Pro Val Ala Tyr Tyr Arg Asn Leu Gln Glu Phe Ser Tyr 
705                 710                 715                 720 


Ser Asn Leu Glu Glu Lys Lys Glu Glu Pro Ala Thr Pro Ala Tyr Thr 
                725                 730                 735     


Ile Ser Ala Thr Glu Leu Leu Glu Lys Gln Ala Thr Pro Arg Glu Pro 
            740                 745                 750         


Glu Leu Leu Tyr Gln Asn Ile Ala Glu Arg Val Lys Glu Leu Pro Ser 
        755                 760                 765             


Ala Gly Leu Val His Tyr Asn Phe Cys Thr Leu Pro Lys Arg Gln Phe 
    770                 775                 780                 


Ala Pro Ser Tyr Glu Ser Arg Arg Gln Asn Gln Asp Arg Ile Asn Lys 
785                 790                 795                 800 


Thr Val Leu Tyr Gly Thr Pro Arg Lys Cys Phe Val Gly Gln Ser Lys 
                805                 810                 815     


Pro Asn His Pro Leu Leu Gln Ala Lys Pro Gln Ser Glu Pro Asp Tyr 
            820                 825                 830         


Leu Glu Val Leu Glu Lys Gln Thr Ala Ile Ser Gln Leu 
        835                 840                 845 


<210>  5369
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  5369

Met Tyr Asn Gly Ser Cys Cys Arg Ile Glu Gly Asp Thr Ile Ser Gln 
1               5                   10                  15      


Val Met Pro Pro Leu Leu Ile Val Ala Phe Val Leu Gly Ala Leu Gly 
            20                  25                  30          


Asn Gly Val Ala Leu Cys Gly Phe Cys Phe His Met Lys Thr Trp Lys 
        35                  40                  45              


Pro Ser Thr Val Tyr Leu Phe Asn Leu Ala Val Ala Asp Phe Leu Leu 
    50                  55                  60                  


Met Ile Cys Leu Pro Phe Arg Thr Asp Tyr Tyr Leu Arg Arg Arg His 
65                  70                  75                  80  


Trp Ala Phe Gly Asp Ile Pro Cys Arg Val Gly Leu Phe Thr Leu Ala 
                85                  90                  95      


Met Asn Arg Ala Gly Ser Ile Val Phe Leu Thr Val Val Ala Ala Asp 
            100                 105                 110         


Arg Tyr Phe Lys Val Val His Pro His His Ala Val Asn Thr Ile Ser 
        115                 120                 125             


Thr Arg Val Ala Ala Gly Ile Val Cys Thr Leu Trp Ala Leu Val Ile 
    130                 135                 140                 


Leu Gly Thr Val Tyr Leu Leu Leu Glu Asn His Leu Cys Val Gln Glu 
145                 150                 155                 160 


Thr Ala Val Ser Cys Glu Ser Phe Ile Met Glu Ser Ala Asn Gly Trp 
                165                 170                 175     


His Asp Ile Met Phe Gln Leu Glu Phe Phe Met Pro Leu Gly Ile Ile 
            180                 185                 190         


Leu Phe Cys Ser Phe Lys Ile Val Trp Ser Leu Arg Arg Arg Gln Gln 
        195                 200                 205             


Leu Ala Arg Gln Ala Arg Met Lys Lys Ala Thr Arg Phe Ile Met Val 
    210                 215                 220                 


Val Ala Ile Val Phe Ile Thr Cys Tyr Leu Pro Ser Val Ser Ala Arg 
225                 230                 235                 240 


Leu Tyr Phe Leu Trp Thr Val Pro Ser Ser Ala Cys Asp Pro Ser Val 
                245                 250                 255     


His Gly Ala Leu His Ile Thr Leu Ser Phe Thr Tyr Met Asn Ser Met 
            260                 265                 270         


Leu Asp Pro Leu Val Tyr Tyr Phe Ser Ser Pro Ser Phe Pro Lys Phe 
        275                 280                 285             


Tyr Asn Lys Leu Lys Ile Cys Ser Leu Lys Pro Lys Gln Pro Gly His 
    290                 295                 300                 


Ser Lys Thr Gln Arg Pro Glu Glu Met Pro Ile Ser Asn Leu Gly Arg 
305                 310                 315                 320 


Arg Ser Cys Ile Ser Val Ala Asn Ser Phe Gln Ser Gln Ser Asp Gly 
                325                 330                 335     


Gln Trp Asp Pro His Ile Val Glu Trp His 
            340                 345     


<210>  5370
<211>  506
<212>  PRT
<213>  Homo sapiens

<400>  5370

Met Ser Val Glu Pro Pro Pro Glu Leu Glu Glu Lys Ala Ala Ser Glu 
1               5                   10                  15      


Pro Glu Ala Gly Ala Met Pro Glu Lys Arg Ala Gly Ala Gln Ala Ala 
            20                  25                  30          


Gly Ser Thr Trp Leu Gln Gly Phe Gly Arg Pro Ser Val Tyr His Ala 
        35                  40                  45              


Ala Ile Val Ile Phe Leu Glu Phe Phe Ala Trp Gly Leu Leu Thr Thr 
    50                  55                  60                  


Pro Met Leu Thr Val Leu His Glu Thr Phe Ser Gln His Thr Phe Leu 
65                  70                  75                  80  


Met Asn Gly Leu Ile Gln Gly Val Lys Gly Leu Leu Ser Phe Leu Ser 
                85                  90                  95      


Ala Pro Leu Ile Gly Ala Leu Ser Asp Val Trp Gly Arg Lys Pro Phe 
            100                 105                 110         


Leu Leu Gly Thr Val Phe Phe Thr Cys Phe Pro Ile Pro Leu Met Arg 
        115                 120                 125             


Ile Ser Pro Trp Trp Tyr Phe Ala Met Ile Ser Val Ser Gly Val Phe 
    130                 135                 140                 


Ser Val Thr Phe Ser Val Ile Phe Ala Tyr Val Ala Asp Val Thr Gln 
145                 150                 155                 160 


Glu His Glu Arg Ser Thr Ala Tyr Gly Trp Val Ser Ala Thr Phe Ala 
                165                 170                 175     


Ala Ser Leu Val Ser Ser Pro Ala Ile Gly Ala Tyr Leu Ser Ala Ser 
            180                 185                 190         


Tyr Gly Asp Ser Leu Val Val Leu Val Ala Thr Val Val Ala Leu Leu 
        195                 200                 205             


Asp Ile Cys Phe Ile Leu Val Ala Val Pro Glu Ser Leu Pro Glu Lys 
    210                 215                 220                 


Met Arg Pro Val Ser Trp Gly Ala Gln Ile Ser Trp Lys Gln Ala Asp 
225                 230                 235                 240 


Pro Phe Ala Ser Leu Lys Lys Val Gly Lys Asp Ser Thr Val Leu Leu 
                245                 250                 255     


Ile Cys Ile Thr Val Phe Leu Ser Tyr Leu Pro Glu Ala Gly Gln Tyr 
            260                 265                 270         


Ser Ser Phe Phe Leu Tyr Leu Arg Gln Val Ile Gly Phe Gly Ser Val 
        275                 280                 285             


Lys Ile Ala Ala Phe Ile Ala Met Val Gly Ile Leu Ser Ile Val Ala 
    290                 295                 300                 


Gln Thr Ala Phe Leu Ser Ile Leu Met Arg Ser Leu Gly Asn Lys Asn 
305                 310                 315                 320 


Thr Val Leu Leu Gly Leu Gly Phe Gln Met Leu Gln Leu Ala Trp Tyr 
                325                 330                 335     


Gly Phe Gly Ser Gln Ala Trp Met Met Trp Ala Ala Gly Thr Val Ala 
            340                 345                 350         


Ala Met Ser Ser Ile Thr Phe Pro Ala Ile Ser Ala Leu Val Ser Arg 
        355                 360                 365             


Asn Ala Glu Ser Asp Gln Gln Gly Val Ala Gln Gly Ile Ile Thr Gly 
    370                 375                 380                 


Ile Arg Gly Leu Cys Asn Gly Leu Gly Pro Ala Leu Tyr Gly Phe Ile 
385                 390                 395                 400 


Phe Tyr Met Phe His Val Glu Leu Thr Glu Leu Gly Pro Lys Leu Asn 
                405                 410                 415     


Ser Asn Asn Val Pro Leu Gln Gly Ala Val Ile Pro Gly Pro Pro Phe 
            420                 425                 430         


Leu Phe Gly Ala Cys Ile Val Leu Met Ser Phe Leu Val Ala Leu Phe 
        435                 440                 445             


Ile Pro Glu Tyr Ser Lys Ala Ser Gly Val Gln Lys His Ser Asn Ser 
    450                 455                 460                 


Ser Ser Gly Ser Leu Thr Asn Thr Pro Glu Arg Gly Ser Asp Glu Asp 
465                 470                 475                 480 


Ile Glu Pro Leu Leu Gln Asp Ser Ser Ile Trp Glu Leu Ser Ser Phe 
                485                 490                 495     


Glu Glu Pro Gly Asn Gln Cys Thr Glu Leu 
            500                 505     


<210>  5371
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  5371

Met Lys Thr Leu Ile Ala Ala Tyr Ser Gly Val Leu Arg Gly Glu Arg 
1               5                   10                  15      


Gln Ala Glu Ala Asp Arg Ser Gln Arg Ser His Gly Gly Pro Ala Leu 
            20                  25                  30          


Ser Arg Glu Gly Ser Gly Arg Trp Gly Thr Gly Ser Ser Ile Leu Ser 
        35                  40                  45              


Ala Leu Gln Asp Leu Phe Ser Val Thr Trp Leu Asn Arg Ser Lys Val 
    50                  55                  60                  


Glu Lys Gln Leu Gln Val Ile Ser Val Leu Gln Trp Val Leu Ser Phe 
65                  70                  75                  80  


Leu Val Leu Gly Val Ala Cys Ser Ala Ile Leu Met Tyr Ile Phe Cys 
                85                  90                  95      


Thr Asp Cys Trp Leu Ile Ala Val Leu Tyr Phe Thr Trp Leu Val Phe 
            100                 105                 110         


Asp Trp Asn Thr Pro Lys Lys Gly Gly Arg Arg Ser Gln Trp Val Arg 
        115                 120                 125             


Asn Trp Ala Val Trp Arg Tyr Phe Arg Asp Tyr Phe Pro Ile Gln Leu 
    130                 135                 140                 


Val Lys Thr His Asn Leu Leu Thr Thr Arg Asn Tyr Ile Phe Gly Tyr 
145                 150                 155                 160 


His Pro His Gly Ile Met Gly Leu Gly Ala Phe Cys Asn Phe Ser Thr 
                165                 170                 175     


Glu Ala Thr Glu Val Ser Lys Lys Phe Pro Gly Ile Arg Pro Tyr Leu 
            180                 185                 190         


Ala Thr Leu Ala Gly Asn Phe Arg Met Pro Val Leu Arg Glu Tyr Leu 
        195                 200                 205             


Met Ser Gly Gly Ile Cys Pro Val Ser Arg Asp Thr Ile Asp Tyr Leu 
    210                 215                 220                 


Leu Ser Lys Asn Gly Ser Gly Asn Ala Ile Ile Ile Val Val Gly Gly 
225                 230                 235                 240 


Ala Ala Glu Ser Leu Ser Ser Met Pro Gly Lys Asn Ala Val Thr Leu 
                245                 250                 255     


Arg Asn Arg Lys Gly Phe Val Lys Leu Ala Leu Arg His Gly Ala Asp 
            260                 265                 270         


Leu Val Pro Ile Tyr Ser Phe Gly Glu Asn Glu Val Tyr Lys Gln Val 
        275                 280                 285             


Ile Phe Glu Glu Gly Ser Trp Gly Arg Trp Val Gln Lys Lys Phe Gln 
    290                 295                 300                 


Lys Tyr Ile Gly Phe Ala Pro Cys Ile Phe His Gly Arg Gly Leu Phe 
305                 310                 315                 320 


Ser Ser Asp Thr Trp Gly Leu Val Pro Tyr Ser Lys Pro Ile Thr Thr 
                325                 330                 335     


Val Val Gly Glu Pro Ile Thr Ile Pro Lys Leu Glu His Pro Thr Gln 
            340                 345                 350         


Gln Asp Ile Asp Leu Tyr His Thr Met Tyr Met Glu Ala Leu Val Lys 
        355                 360                 365             


Leu Phe Asp Lys His Lys Thr Lys Phe Gly Leu Pro Glu Thr Glu Val 
    370                 375                 380                 


Leu Glu Val Asn 
385             


<210>  5372
<211>  652
<212>  PRT
<213>  Homo sapiens

<400>  5372

Met Gln Gly Pro Leu Leu Leu Pro Gly Leu Cys Phe Leu Leu Ser Leu 
1               5                   10                  15      


Phe Gly Ala Val Thr Gln Lys Thr Lys Thr Ser Cys Ala Lys Cys Pro 
            20                  25                  30          


Pro Asn Ala Ser Cys Val Asn Asn Thr His Cys Thr Cys Asn His Gly 
        35                  40                  45              


Tyr Thr Ser Gly Ser Gly Gln Lys Leu Phe Thr Phe Pro Leu Glu Thr 
    50                  55                  60                  


Cys Asn Asp Ile Asn Glu Cys Thr Pro Pro Tyr Ser Val Tyr Cys Gly 
65                  70                  75                  80  


Phe Asn Ala Val Cys Tyr Asn Val Glu Gly Ser Phe Tyr Cys Gln Cys 
                85                  90                  95      


Val Pro Gly Tyr Arg Leu His Ser Gly Asn Glu Gln Phe Ser Asn Ser 
            100                 105                 110         


Asn Glu Asn Thr Cys Gln Asp Thr Thr Ser Ser Lys Thr Thr Glu Gly 
        115                 120                 125             


Arg Lys Glu Leu Gln Lys Ile Val Asp Lys Phe Glu Ser Leu Leu Thr 
    130                 135                 140                 


Asn Gln Thr Leu Trp Arg Thr Glu Gly Arg Gln Glu Ile Ser Ser Thr 
145                 150                 155                 160 


Ala Thr Thr Ile Leu Arg Asp Val Glu Ser Lys Val Leu Glu Thr Ala 
                165                 170                 175     


Leu Lys Asp Pro Glu Gln Lys Val Leu Lys Ile Gln Asn Asp Ser Val 
            180                 185                 190         


Ala Ile Glu Thr Gln Ala Ile Thr Asp Asn Cys Ser Glu Glu Arg Lys 
        195                 200                 205             


Thr Phe Asn Leu Asn Val Gln Met Asn Ser Met Asp Ile Arg Cys Ser 
    210                 215                 220                 


Asp Ile Ile Gln Gly Asp Thr Gln Gly Pro Ser Ala Ile Ala Phe Ile 
225                 230                 235                 240 


Ser Tyr Ser Ser Leu Gly Asn Ile Ile Asn Ala Thr Phe Phe Glu Glu 
                245                 250                 255     


Met Asp Lys Lys Asp Gln Val Tyr Leu Asn Ser Gln Val Val Ser Ala 
            260                 265                 270         


Ala Ile Gly Pro Lys Arg Asn Val Ser Leu Ser Lys Ser Val Thr Leu 
        275                 280                 285             


Thr Phe Gln His Val Lys Met Thr Pro Ser Thr Lys Lys Val Phe Cys 
    290                 295                 300                 


Val Tyr Trp Lys Ser Thr Gly Gln Gly Ser Gln Trp Ser Arg Asp Gly 
305                 310                 315                 320 


Cys Phe Leu Ile His Val Asn Lys Ser His Thr Met Cys Asn Cys Ser 
                325                 330                 335     


His Leu Ser Ser Phe Ala Val Leu Met Ala Leu Thr Ser Gln Glu Glu 
            340                 345                 350         


Asp Pro Val Leu Thr Val Ile Thr Tyr Val Gly Leu Ser Val Ser Leu 
        355                 360                 365             


Leu Cys Leu Leu Leu Ala Ala Leu Thr Phe Leu Leu Cys Lys Ala Ile 
    370                 375                 380                 


Arg Asn Thr Ser Thr Ser Leu His Leu Gln Leu Ser Leu Cys Leu Phe 
385                 390                 395                 400 


Leu Ala His Leu Leu Phe Leu Val Gly Ile Asp Arg Thr Glu Pro Lys 
                405                 410                 415     


Val Leu Cys Ser Ile Ile Ala Gly Ala Leu His Tyr Leu Tyr Leu Ala 
            420                 425                 430         


Ala Phe Thr Trp Met Leu Leu Glu Gly Val His Leu Phe Leu Thr Ala 
        435                 440                 445             


Arg Asn Leu Thr Val Val Asn Tyr Ser Ser Ile Asn Arg Leu Met Lys 
    450                 455                 460                 


Trp Ile Met Phe Pro Val Gly Tyr Gly Val Pro Ala Val Thr Val Ala 
465                 470                 475                 480 


Ile Ser Ala Ala Ser Trp Pro His Leu Tyr Gly Thr Ala Asp Arg Cys 
                485                 490                 495     


Trp Leu His Leu Asp Gln Gly Phe Met Trp Ser Phe Leu Gly Pro Val 
            500                 505                 510         


Cys Ala Ile Phe Ser Ala Asn Leu Val Leu Phe Ile Leu Val Phe Trp 
        515                 520                 525             


Ile Leu Lys Arg Lys Leu Ser Ser Leu Asn Ser Glu Val Ser Thr Ile 
    530                 535                 540                 


Gln Asn Thr Arg Met Leu Ala Phe Lys Ala Thr Ala Gln Leu Phe Ile 
545                 550                 555                 560 


Leu Gly Cys Thr Trp Cys Leu Gly Leu Leu Gln Val Gly Pro Ala Ala 
                565                 570                 575     


Gln Val Met Ala Tyr Leu Phe Thr Ile Ile Asn Ser Leu Gln Gly Phe 
            580                 585                 590         


Phe Ile Phe Leu Val Tyr Cys Leu Leu Ser Gln Gln Val Gln Lys Gln 
        595                 600                 605             


Tyr Gln Lys Trp Phe Arg Glu Ile Val Lys Ser Lys Ser Glu Ser Glu 
    610                 615                 620                 


Thr Tyr Thr Leu Ser Ser Lys Met Gly Pro Asp Ser Lys Pro Ser Glu 
625                 630                 635                 640 


Gly Asp Val Phe Pro Gly Gln Val Lys Arg Lys Tyr 
                645                 650         


<210>  5373
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  5373

Met Ala Pro Ala Arg Ala Gly Phe Cys Pro Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Gly Leu Trp Val Ala Glu Ile Pro Val Ser Ala Lys Pro Lys Gly 
            20                  25                  30          


Met Thr Ser Ser Gln Trp Phe Lys Ile Gln His Met Gln Pro Ser Pro 
        35                  40                  45              


Gln Ala Cys Asn Ser Ala Met Lys Asn Ile Asn Lys His Thr Lys Arg 
    50                  55                  60                  


Cys Lys Asp Leu Asn Thr Phe Leu His Glu Pro Phe Ser Ser Val Ala 
65                  70                  75                  80  


Ala Thr Cys Gln Thr Pro Lys Ile Ala Cys Lys Asn Gly Asp Lys Asn 
                85                  90                  95      


Cys His Gln Ser His Gly Ala Val Ser Leu Thr Met Cys Lys Leu Thr 
            100                 105                 110         


Ser Gly Lys Tyr Pro Asn Cys Arg Tyr Lys Glu Lys Arg Gln Asn Lys 
        115                 120                 125             


Ser Tyr Val Val Ala Cys Lys Pro Pro Gln Lys Lys Asp Ser Gln Gln 
    130                 135                 140                 


Phe His Leu Val Pro Val His Leu Asp Arg Val Leu 
145                 150                 155     


<210>  5374
<211>  1382
<212>  PRT
<213>  Homo sapiens

<400>  5374

Met Thr Arg Lys Arg Thr Tyr Trp Val Pro Asn Ser Ser Gly Gly Leu 
1               5                   10                  15      


Val Asn Arg Gly Ile Asp Ile Gly Asp Asp Met Val Ser Gly Leu Ile 
            20                  25                  30          


Tyr Lys Thr Tyr Thr Leu Gln Asp Gly Pro Trp Ser Gln Gln Glu Arg 
        35                  40                  45              


Asn Pro Glu Ala Pro Gly Arg Ala Ala Val Pro Pro Trp Gly Lys Tyr 
    50                  55                  60                  


Asp Ala Ala Leu Arg Thr Met Ile Pro Phe Arg Pro Lys Pro Arg Phe 
65                  70                  75                  80  


Pro Ala Pro Gln Pro Leu Asp Asn Ala Gly Leu Phe Ser Tyr Leu Thr 
                85                  90                  95      


Val Ser Trp Leu Thr Pro Leu Met Ile Gln Ser Leu Arg Ser Arg Leu 
            100                 105                 110         


Asp Glu Asn Thr Ile Pro Pro Leu Ser Val His Asp Ala Ser Asp Lys 
        115                 120                 125             


Asn Val Gln Arg Leu His Arg Leu Trp Glu Glu Glu Val Ser Arg Arg 
    130                 135                 140                 


Gly Ile Glu Lys Ala Ser Val Leu Leu Val Met Leu Arg Phe Gln Arg 
145                 150                 155                 160 


Thr Arg Leu Ile Phe Asp Ala Leu Leu Gly Ile Cys Phe Cys Ile Ala 
                165                 170                 175     


Ser Val Leu Gly Pro Ile Leu Ile Ile Pro Lys Ile Leu Glu Tyr Ser 
            180                 185                 190         


Glu Glu Gln Leu Gly Asn Val Val His Gly Val Gly Leu Cys Phe Ala 
        195                 200                 205             


Leu Phe Leu Ser Glu Cys Val Lys Ser Leu Ser Phe Ser Ser Ser Trp 
    210                 215                 220                 


Ile Ile Asn Gln Arg Thr Ala Ile Arg Phe Arg Ala Ala Val Ser Ser 
225                 230                 235                 240 


Phe Ala Phe Glu Lys Leu Ile Gln Phe Lys Ser Val Ile His Ile Thr 
                245                 250                 255     


Ser Gly Glu Ala Ile Ser Phe Phe Thr Gly Asp Val Asn Tyr Leu Phe 
            260                 265                 270         


Glu Gly Val Cys Tyr Gly Pro Leu Val Leu Ile Thr Cys Ala Ser Leu 
        275                 280                 285             


Val Ile Cys Ser Ile Ser Ser Tyr Phe Ile Ile Gly Tyr Thr Ala Phe 
    290                 295                 300                 


Ile Ala Ile Leu Cys Tyr Leu Leu Val Phe Pro Leu Ala Val Phe Met 
305                 310                 315                 320 


Thr Arg Met Ala Val Lys Ala Gln His His Thr Ser Glu Val Ser Asp 
                325                 330                 335     


Gln Arg Ile Arg Val Thr Ser Glu Val Leu Thr Cys Ile Lys Leu Ile 
            340                 345                 350         


Lys Met Tyr Thr Trp Glu Lys Pro Phe Ala Lys Ile Ile Glu Asp Leu 
        355                 360                 365             


Arg Arg Lys Glu Arg Lys Leu Leu Glu Lys Cys Gly Leu Val Gln Ser 
    370                 375                 380                 


Leu Thr Ser Ile Thr Leu Phe Ile Ile Pro Thr Val Ala Thr Ala Val 
385                 390                 395                 400 


Trp Val Leu Ile His Thr Ser Leu Lys Leu Lys Leu Thr Ala Ser Met 
                405                 410                 415     


Ala Phe Ser Met Leu Ala Ser Leu Asn Leu Leu Arg Leu Ser Val Phe 
            420                 425                 430         


Phe Val Pro Ile Ala Val Lys Gly Leu Thr Asn Ser Lys Ser Ala Val 
        435                 440                 445             


Met Arg Phe Lys Lys Phe Phe Leu Gln Glu Ser Pro Val Phe Tyr Val 
    450                 455                 460                 


Gln Thr Leu Gln Asp Pro Ser Lys Ala Leu Val Phe Glu Glu Ala Thr 
465                 470                 475                 480 


Leu Ser Trp Gln Gln Thr Cys Pro Gly Ile Val Asn Gly Ala Leu Glu 
                485                 490                 495     


Leu Glu Arg Asn Gly His Ala Ser Glu Gly Met Thr Arg Pro Arg Asp 
            500                 505                 510         


Ala Leu Gly Pro Glu Glu Glu Gly Asn Ser Leu Gly Pro Glu Leu His 
        515                 520                 525             


Lys Ile Asn Leu Val Val Ser Lys Gly Met Met Leu Gly Val Cys Gly 
    530                 535                 540                 


Asn Thr Gly Ser Gly Lys Ser Ser Leu Leu Ser Ala Ile Leu Glu Glu 
545                 550                 555                 560 


Met His Leu Leu Glu Gly Ser Val Gly Val Gln Gly Ser Leu Ala Tyr 
                565                 570                 575     


Val Pro Gln Gln Ala Trp Ile Val Ser Gly Asn Ile Arg Glu Asn Ile 
            580                 585                 590         


Leu Met Gly Gly Ala Tyr Asp Lys Ala Arg Tyr Leu Gln Val Leu His 
        595                 600                 605             


Cys Cys Ser Leu Asn Arg Asp Leu Glu Leu Leu Pro Phe Gly Asp Met 
    610                 615                 620                 


Thr Glu Ile Gly Glu Arg Gly Leu Asn Leu Ser Gly Gly Gln Lys Gln 
625                 630                 635                 640 


Arg Ile Ser Leu Ala Arg Ala Val Tyr Ser Asp Arg Gln Ile Tyr Leu 
                645                 650                 655     


Leu Asp Asp Pro Leu Ser Ala Val Asp Ala His Val Gly Lys His Ile 
            660                 665                 670         


Phe Glu Glu Cys Ile Lys Lys Thr Leu Arg Gly Lys Thr Val Val Leu 
        675                 680                 685             


Val Thr His Gln Leu Gln Tyr Leu Glu Phe Cys Gly Gln Ile Ile Leu 
    690                 695                 700                 


Leu Glu Asn Gly Lys Ile Cys Glu Asn Gly Thr His Ser Glu Leu Met 
705                 710                 715                 720 


Gln Lys Lys Gly Lys Tyr Ala Gln Leu Ile Gln Lys Met His Lys Glu 
                725                 730                 735     


Ala Thr Ser Asp Met Leu Gln Asp Thr Ala Lys Ile Ala Glu Lys Pro 
            740                 745                 750         


Lys Val Glu Ser Gln Ala Leu Ala Thr Ser Leu Glu Glu Ser Leu Asn 
        755                 760                 765             


Gly Asn Ala Val Pro Glu His Gln Leu Thr Gln Glu Glu Glu Met Glu 
    770                 775                 780                 


Glu Gly Ser Leu Ser Trp Arg Val Tyr His His Tyr Ile Gln Ala Ala 
785                 790                 795                 800 


Gly Gly Tyr Met Val Ser Cys Ile Ile Phe Phe Phe Val Val Leu Ile 
                805                 810                 815     


Val Phe Leu Thr Ile Phe Ser Phe Trp Trp Leu Ser Tyr Trp Leu Glu 
            820                 825                 830         


Gln Gly Ser Gly Thr Asn Ser Ser Arg Glu Ser Asn Gly Thr Met Ala 
        835                 840                 845             


Asp Leu Gly Asn Ile Ala Asp Asn Pro Gln Leu Ser Phe Tyr Gln Leu 
    850                 855                 860                 


Val Tyr Gly Leu Asn Ala Leu Leu Leu Ile Cys Val Gly Val Cys Ser 
865                 870                 875                 880 


Ser Gly Ile Phe Thr Lys Val Thr Arg Lys Ala Ser Thr Ala Leu His 
                885                 890                 895     


Asn Lys Leu Phe Asn Lys Val Phe Arg Cys Pro Met Ser Phe Phe Asp 
            900                 905                 910         


Thr Ile Pro Ile Gly Arg Leu Leu Asn Cys Phe Ala Gly Asp Leu Glu 
        915                 920                 925             


Gln Leu Asp Gln Leu Leu Pro Ile Phe Ser Glu Gln Phe Leu Val Leu 
    930                 935                 940                 


Ser Leu Met Val Ile Ala Val Leu Leu Ile Val Ser Val Leu Ser Pro 
945                 950                 955                 960 


Tyr Ile Leu Leu Met Gly Ala Ile Ile Met Val Ile Cys Phe Ile Tyr 
                965                 970                 975     


Tyr Met Met Phe Lys Lys Ala Ile Gly Val Phe Lys Arg Leu Glu Asn 
            980                 985                 990         


Tyr Ser Arg Ser Pro Leu Phe Ser  His Ile Leu Asn Ser  Leu Gln Gly 
        995                 1000                 1005             


Leu Ser  Ser Ile His Val Tyr  Gly Lys Thr Glu Asp  Phe Ile Ser 
    1010                 1015                 1020             


Gln Phe  Lys Arg Leu Thr Asp  Ala Gln Asn Asn Tyr  Leu Leu Leu 
    1025                 1030                 1035             


Phe Leu  Ser Ser Thr Arg Trp  Met Ala Leu Arg Leu  Glu Ile Met 
    1040                 1045                 1050             


Thr Asn  Leu Val Thr Leu Ala  Val Ala Leu Phe Val  Ala Phe Gly 
    1055                 1060                 1065             


Ile Ser  Ser Thr Pro Tyr Ser  Phe Lys Val Met Ala  Val Asn Ile 
    1070                 1075                 1080             


Val Leu  Gln Leu Ala Ser Ser  Phe Gln Ala Thr Ala  Arg Ile Gly 
    1085                 1090                 1095             


Leu Glu  Thr Glu Ala Gln Phe  Thr Ala Val Glu Arg  Ile Leu Gln 
    1100                 1105                 1110             


Tyr Met  Lys Met Cys Val Ser  Glu Ala Pro Leu His  Met Glu Gly 
    1115                 1120                 1125             


Thr Ser  Cys Pro Gln Gly Trp  Pro Gln His Gly Glu  Ile Ile Phe 
    1130                 1135                 1140             


Gln Asp  Tyr His Met Lys Tyr  Arg Asp Asn Thr Pro  Thr Val Leu 
    1145                 1150                 1155             


His Gly  Ile Asn Leu Thr Ile  Arg Gly His Glu Val  Val Gly Ile 
    1160                 1165                 1170             


Val Gly  Arg Thr Gly Ser Gly  Lys Ser Ser Leu Gly  Met Ala Leu 
    1175                 1180                 1185             


Phe Arg  Leu Val Glu Pro Met  Ala Gly Arg Ile Leu  Ile Asp Gly 
    1190                 1195                 1200             


Val Asp  Ile Cys Ser Ile Gly  Leu Glu Asp Leu Arg  Ser Lys Leu 
    1205                 1210                 1215             


Ser Val  Ile Pro Gln Asp Pro  Val Leu Leu Ser Gly  Thr Ile Arg 
    1220                 1225                 1230             


Phe Asn  Leu Asp Pro Phe Asp  Arg His Thr Asp Gln  Gln Ile Trp 
    1235                 1240                 1245             


Asp Ala  Leu Glu Arg Thr Phe  Leu Thr Lys Ala Ile  Ser Lys Phe 
    1250                 1255                 1260             


Pro Lys  Lys Leu His Thr Asp  Val Val Glu Asn Gly  Gly Asn Phe 
    1265                 1270                 1275             


Ser Val  Gly Glu Arg Gln Leu  Leu Cys Ile Ala Arg  Ala Val Leu 
    1280                 1285                 1290             


Arg Asn  Ser Lys Ile Ile Leu  Ile Asp Glu Ala Thr  Ala Ser Ile 
    1295                 1300                 1305             


Asp Met  Glu Thr Asp Thr Leu  Ile Gln Arg Thr Ile  Arg Glu Ala 
    1310                 1315                 1320             


Phe Gln  Gly Cys Thr Val Leu  Val Ile Ala His Arg  Val Thr Thr 
    1325                 1330                 1335             


Val Leu  Asn Cys Asp His Ile  Leu Val Met Gly Asn  Gly Lys Val 
    1340                 1345                 1350             


Val Glu  Phe Asp Arg Pro Glu  Val Leu Arg Lys Lys  Pro Gly Ser 
    1355                 1360                 1365             


Leu Phe  Ala Ala Leu Met Ala  Thr Ala Thr Ser Ser  Leu Arg 
    1370                 1375                 1380         


<210>  5375
<211>  725
<212>  PRT
<213>  Homo sapiens

<400>  5375

Met Glu Pro Gly Asp Ala Ala Arg Pro Gly Ser Gly Arg Ala Thr Gly 
1               5                   10                  15      


Ala Pro Pro Pro Arg Leu Leu Leu Leu Pro Leu Leu Leu Gly Trp Gly 
            20                  25                  30          


Leu Arg Val Ala Ala Ala Ala Ser Ala Ser Ser Ser Gly Ala Ala Ala 
        35                  40                  45              


Glu Asp Ser Ser Ala Met Glu Glu Leu Ala Thr Glu Lys Glu Ala Glu 
    50                  55                  60                  


Glu Ser His Arg Gln Asp Ser Val Ser Leu Leu Thr Phe Ile Leu Leu 
65                  70                  75                  80  


Leu Thr Leu Thr Ile Leu Thr Ile Trp Leu Phe Lys His Arg Arg Val 
                85                  90                  95      


Arg Phe Leu His Glu Thr Gly Leu Ala Met Ile Tyr Gly Leu Ile Val 
            100                 105                 110         


Gly Val Ile Leu Arg Tyr Gly Thr Pro Ala Thr Ser Gly Arg Asp Lys 
        115                 120                 125             


Ser Leu Ser Cys Thr Gln Glu Asp Arg Ala Phe Ser Thr Leu Leu Val 
    130                 135                 140                 


Asn Val Ser Gly Lys Phe Phe Glu Tyr Thr Leu Lys Gly Glu Ile Ser 
145                 150                 155                 160 


Pro Gly Lys Ile Asn Ser Val Glu Gln Asn Asp Met Leu Arg Lys Val 
                165                 170                 175     


Thr Phe Asp Pro Glu Val Phe Phe Asn Ile Leu Leu Pro Pro Ile Ile 
            180                 185                 190         


Phe His Ala Gly Tyr Ser Leu Lys Lys Arg His Phe Phe Arg Asn Leu 
        195                 200                 205             


Gly Ser Ile Leu Ala Tyr Ala Phe Leu Gly Thr Ala Val Ser Cys Phe 
    210                 215                 220                 


Ile Ile Gly Asn Leu Met Tyr Gly Val Val Lys Leu Met Lys Ile Met 
225                 230                 235                 240 


Gly Gln Leu Ser Asp Lys Phe Tyr Tyr Thr Asp Cys Leu Phe Phe Gly 
                245                 250                 255     


Ala Ile Ile Ser Ala Thr Asp Pro Val Thr Val Leu Ala Ile Phe Asn 
            260                 265                 270         


Glu Leu His Ala Asp Val Asp Leu Tyr Ala Leu Leu Phe Gly Glu Ser 
        275                 280                 285             


Val Leu Asn Asp Ala Val Ala Ile Val Leu Ser Ser Ser Ile Val Ala 
    290                 295                 300                 


Tyr Gln Pro Ala Gly Leu Asn Thr His Ala Phe Asp Ala Ala Ala Phe 
305                 310                 315                 320 


Phe Lys Ser Val Gly Ile Phe Leu Gly Ile Phe Ser Gly Ser Phe Thr 
                325                 330                 335     


Met Gly Ala Val Thr Gly Val Asn Ala Asn Val Thr Lys Phe Thr Lys 
            340                 345                 350         


Leu His Cys Phe Pro Leu Leu Glu Thr Ala Leu Phe Phe Leu Met Ser 
        355                 360                 365             


Trp Ser Thr Phe Leu Leu Ala Glu Ala Cys Gly Phe Thr Gly Val Val 
    370                 375                 380                 


Ala Val Leu Phe Cys Gly Ile Thr Gln Ala His Tyr Thr Tyr Asn Asn 
385                 390                 395                 400 


Leu Ser Val Glu Ser Arg Ser Arg Thr Lys Gln Leu Phe Glu Val Leu 
                405                 410                 415     


His Phe Leu Ala Glu Asn Phe Ile Phe Ser Tyr Met Gly Leu Ala Leu 
            420                 425                 430         


Phe Thr Phe Gln Lys His Val Phe Ser Pro Ile Phe Ile Ile Gly Ala 
        435                 440                 445             


Phe Val Ala Ile Phe Leu Gly Arg Ala Ala His Ile Tyr Pro Leu Ser 
    450                 455                 460                 


Phe Phe Leu Asn Leu Gly Arg Arg His Lys Ile Gly Trp Asn Phe Gln 
465                 470                 475                 480 


His Met Met Met Phe Ser Gly Leu Arg Gly Ala Met Ala Phe Ala Leu 
                485                 490                 495     


Ala Ile Arg Asp Thr Ala Ser Tyr Ala Arg Gln Met Met Phe Thr Thr 
            500                 505                 510         


Thr Leu Leu Ile Val Phe Phe Thr Val Trp Ile Ile Gly Gly Gly Thr 
        515                 520                 525             


Thr Pro Met Leu Ser Trp Leu Asn Ile Arg Val Gly Val Glu Glu Pro 
    530                 535                 540                 


Ser Glu Glu Asp Gln Asn Glu His His Trp Gln Tyr Phe Arg Val Gly 
545                 550                 555                 560 


Val Asp Pro Asp Gln Asp Pro Pro Pro Asn Asn Asp Ser Phe Gln Val 
                565                 570                 575     


Leu Gln Gly Asp Gly Pro Asp Ser Ala Arg Gly Asn Arg Thr Lys Gln 
            580                 585                 590         


Glu Ser Ala Trp Ile Phe Arg Leu Trp Tyr Ser Phe Asp His Asn Tyr 
        595                 600                 605             


Leu Lys Pro Ile Leu Thr His Ser Gly Pro Pro Leu Thr Thr Thr Leu 
    610                 615                 620                 


Pro Ala Trp Cys Gly Leu Leu Ala Arg Cys Leu Thr Ser Pro Gln Val 
625                 630                 635                 640 


Tyr Asp Asn Gln Glu Pro Leu Arg Glu Glu Asp Ser Asp Phe Ile Leu 
                645                 650                 655     


Thr Glu Gly Asp Leu Thr Leu Thr Tyr Gly Asp Ser Thr Val Thr Ala 
            660                 665                 670         


Asn Gly Ser Ser Ser Ser His Thr Ala Ser Thr Ser Leu Glu Gly Ser 
        675                 680                 685             


Arg Arg Thr Lys Ser Ser Ser Glu Glu Val Leu Glu Arg Asp Leu Gly 
    690                 695                 700                 


Met Gly Asp Gln Lys Val Ser Ser Arg Gly Thr Arg Leu Val Phe Pro 
705                 710                 715                 720 


Leu Glu Asp Asn Ala 
                725 


<210>  5376
<211>  679
<212>  PRT
<213>  Homo sapiens

<400>  5376

Met Glu Ser Thr Ser Gln Asp Arg Arg Ala Thr His Val Ile Thr Ile 
1               5                   10                  15      


Lys Pro Asn Glu Thr Val Leu Thr Ala Phe Pro Tyr Arg Pro His Ser 
            20                  25                  30          


Ser Leu Leu Asp Phe Leu Lys Gly Glu Pro Arg Val Leu Gly Ala Thr 
        35                  40                  45              


Gln Ile Leu Leu Ala Leu Ile Ile Val Gly Phe Gly Thr Ile Phe Ala 
    50                  55                  60                  


Leu Asn Tyr Ile Gly Phe Ser Gln Arg Leu Pro Leu Val Val Leu Thr 
65                  70                  75                  80  


Gly Tyr Pro Phe Trp Gly Ala Leu Ile Phe Ile Leu Thr Gly Tyr Leu 
                85                  90                  95      


Thr Val Thr Asp Lys Lys Ser Lys Leu Leu Gly Gln Gly Val Thr Gly 
            100                 105                 110         


Met Asn Val Ile Ser Ser Leu Val Ala Ile Thr Gly Ile Thr Phe Thr 
        115                 120                 125             


Ile Leu Ser Tyr Arg His Gln Asp Lys Tyr Cys Gln Met Pro Ser Phe 
    130                 135                 140                 


Glu Glu Ile Cys Val Phe Ser Arg Thr Leu Phe Ile Val Leu Phe Phe 
145                 150                 155                 160 


Leu Pro Ser Asp Val Thr Gln Asn Ser Glu Gln Pro Ala Pro Glu Glu 
                165                 170                 175     


Asn Asp Gln Leu Gln Phe Val Leu Gln Glu Glu Phe Ser Ser Asp Asp 
            180                 185                 190         


Ser Thr Thr Asn Ala Gln Ser Val Ile Phe Gly Gly Tyr Ala Phe Phe 
        195                 200                 205             


Lys Leu Thr Leu Ser Arg Ser Pro Leu Val Ser Gln Pro Gly Asn Lys 
    210                 215                 220                 


Gly Arg Glu Phe Val Pro Asp Glu Gln Lys Gln Ser Ile Leu Pro Ser 
225                 230                 235                 240 


Pro Lys Phe Ser Glu Glu Glu Ile Glu Pro Leu Pro Pro Thr Leu Glu 
                245                 250                 255     


Lys Lys Pro Ser Glu Asn Met Ser Ile Gln Leu Asp Ser Thr Phe Lys 
            260                 265                 270         


Gln Met Lys Asp Glu Asp Leu Gln Ser Ala Ile Val Gln Pro Ser Gln 
        275                 280                 285             


Met Gln Thr Lys Leu Leu Gln Asp Gln Ala Ala Ser Leu Gln Val Phe 
    290                 295                 300                 


Pro Ser His Ser Ala Leu Lys Leu Glu Asp Ile Ser Pro Glu Asp Leu 
305                 310                 315                 320 


Pro Ser Gln Ala Leu Pro Val Glu Gly Leu Ser Glu Gln Thr Met Pro 
                325                 330                 335     


Ser Lys Ser Thr Ser Ser His Val Lys Gln Ser Ser Asn Leu Thr Ala 
            340                 345                 350         


Asn Asp Leu Pro Pro Gln Gly Ile Leu Ser Gln Asp Thr Ser Ser Gln 
        355                 360                 365             


Asp Met Leu Phe His Asp Met Thr Ser Gln Asp Met Gln Ser Leu Asp 
    370                 375                 380                 


Met Leu Ser Gln Asp Thr Pro Ser His Ala Met Pro Pro Gln Asp Ile 
385                 390                 395                 400 


Pro Ser Gln Asp Met Leu Ser Gln Ala Leu Ser Ala His Ala Ile Leu 
                405                 410                 415     


Pro Glu Ala Ser Thr Ser His Ile Val Gln Phe Pro Glu Ile Gln His 
            420                 425                 430         


Leu Leu Gln Gln Pro Pro Asp Leu Gln Pro Glu Asn Thr Glu Pro Gln 
        435                 440                 445             


Asn Gln Gln Ile Leu Gln Met Ser Tyr Gln Asp Ile Arg Ser Glu Val 
    450                 455                 460                 


Met Glu Glu Thr Lys Glu Trp Lys Ser Glu Glu Glu Leu His Arg Arg 
465                 470                 475                 480 


Lys Ser Ser Arg Arg His Ser Leu Asn Gln Gln Thr Lys Ala Leu Gln 
                485                 490                 495     


Tyr Leu Arg Arg His Ser Leu Asp Val Gln Ala Lys Gly Gln Lys Ser 
            500                 505                 510         


Ser Lys Arg His Ser Leu Asp Gln Gln Ser Lys Gly Trp Gln Ser Pro 
        515                 520                 525             


Lys Gln Lys Ser Leu Asp Gln Gln Ile Lys Asp Trp Leu Ser Pro Lys 
    530                 535                 540                 


Arg His Ser Val Asp Lys Gln Ala Gln Leu Asn Gln Thr Lys Glu Gln 
545                 550                 555                 560 


Leu Pro Asp Gln Gln Ala Glu Asp Gln Gln Ala Lys Gly Glu Gln Tyr 
                565                 570                 575     


Pro Glu Gly Gln Ser Lys Asp Gly Gln Val Lys Asp Gln Gln Thr Asp 
            580                 585                 590         


Lys Glu Gln Asn Ser Lys Lys Gln Thr Gln Asp Gln Gln Thr Glu Asp 
        595                 600                 605             


Gln Pro Ala Gln Glu Lys Lys Ser Pro Lys Gly Gln Phe Gln Asn Val 
    610                 615                 620                 


Gln Ala Glu Gly Gln Gln Ala Gln Val Glu Lys Val Pro Lys Leu Leu 
625                 630                 635                 640 


Cys Gln Asp Ser Glu Ser Gln Ile Gln Gln Tyr Gln Phe Trp Gln Phe 
                645                 650                 655     


His Lys Gly Asn Leu Gln Ala Gly Gln Pro Arg Thr Val Asn Leu Leu 
            660                 665                 670         


Ala Lys Asn Pro Leu Thr Gly 
        675                 


<210>  5377
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  5377

Met Gly Asp Trp Asn Leu Leu Gly Gly Ile Leu Glu Glu Val His Ser 
1               5                   10                  15      


His Ser Thr Ile Val Gly Lys Ile Trp Leu Thr Ile Leu Phe Ile Phe 
            20                  25                  30          


Arg Met Leu Val Leu Arg Val Ala Ala Glu Asp Val Trp Asp Asp Glu 
        35                  40                  45              


Gln Ser Ala Phe Ala Cys Asn Thr Arg Gln Pro Gly Cys Asn Asn Ile 
    50                  55                  60                  


Cys Tyr Asp Asp Ala Phe Pro Ile Ser Leu Ile Arg Phe Trp Val Leu 
65                  70                  75                  80  


Gln Ile Ile Phe Val Ser Ser Pro Ser Leu Val Tyr Met Gly His Ala 
                85                  90                  95      


Leu Tyr Arg Leu Arg Ala Phe Glu Lys Asp Arg Gln Arg Lys Lys Ser 
            100                 105                 110         


His Leu Arg Ala Gln Met Glu Asn Pro Asp Leu Asp Leu Glu Glu Gln 
        115                 120                 125             


Gln Arg Ile Asp Arg Glu Leu Arg Arg Leu Glu Glu Gln Lys Arg Ile 
    130                 135                 140                 


His Lys Val Pro Leu Lys Gly Cys Leu Leu Arg Thr Tyr Val Leu His 
145                 150                 155                 160 


Ile Leu Thr Arg Ser Val Leu Glu Val Gly Phe Met Ile Gly Gln Tyr 
                165                 170                 175     


Ile Leu Tyr Gly Phe Gln Met His Pro Leu Tyr Lys Cys Thr Gln Pro 
            180                 185                 190         


Pro Cys Pro Asn Ala Val Asp Cys Phe Val Ser Arg Pro Thr Glu Lys 
        195                 200                 205             


Thr Ile Phe Met Leu Phe Met His Ser Ile Ala Ala Ile Ser Leu Leu 
    210                 215                 220                 


Leu Asn Ile Leu Glu Ile Phe His Leu Gly Ile Arg Lys Ile Met Arg 
225                 230                 235                 240 


Thr Leu Tyr Lys Lys Ser Ser Ser Glu Gly Ile Glu Asp Glu Thr Gly 
                245                 250                 255     


Pro Pro Phe His Leu Lys Lys Tyr Ser Val Ala Gln Gln Cys Met Ile 
            260                 265                 270         


Cys Ser Ser Leu Pro Glu Arg Ile Ser Pro Leu Gln Ala Asn Asn Gln 
        275                 280                 285             


Gln Gln Val Ile Arg Val Asn Val Pro Lys Ser Lys Thr Met Trp Gln 
    290                 295                 300                 


Ile Pro Gln Pro Arg Gln Leu Glu Val Asp Pro Ser Asn Gly Lys Lys 
305                 310                 315                 320 


Asp Trp Ser Glu Lys Asp Gln His Ser Gly Gln Leu His Val His Ser 
                325                 330                 335     


Pro Cys Pro Trp Ala Gly Ser Ala Gly Asn Gln His Leu Gly Gln Gln 
            340                 345                 350         


Ser Asp His Ser Ser Phe Gly Leu Gln Asn Thr Met Ser Gln Ser Trp 
        355                 360                 365             


Leu Gly Thr Thr Thr Ala Pro Arg Asn Cys Pro Ser Phe Ala Val Gly 
    370                 375                 380                 


Thr Trp Glu Gln Ser Gln Asp Pro Glu Pro Ser Gly Glu Pro Leu Thr 
385                 390                 395                 400 


Asp Leu His Ser His Cys Arg Asp Ser Glu Gly Ser Met Arg Glu Ser 
                405                 410                 415     


Gly Val Trp Ile Asp Arg Ser Arg Pro Gly Ser Arg Lys Ala Ser Phe 
            420                 425                 430         


Leu Ser Arg Leu Leu Ser Glu Lys Arg His Leu His Ser Asp Ser Gly 
        435                 440                 445             


Ser Ser Gly Ser Arg Asn Ser Ser Cys Leu Asp Phe Pro His Trp Glu 
    450                 455                 460                 


Asn Ser Pro Ser Pro Leu Pro Ser Val Thr Gly His Arg Thr Ser Met 
465                 470                 475                 480 


Val Arg Gln Ala Ala Leu Pro Ile Met Glu Leu Ser Gln Glu Leu Phe 
                485                 490                 495     


His Ser Gly Cys Phe Leu Phe Pro Phe Phe Leu Pro Gly Val Cys Met 
            500                 505                 510         


Tyr Val Cys Val Asp Arg Glu Ala Asp Gly Gly Gly Asp Tyr Leu Trp 
        515                 520                 525             


Arg Asp Lys Ile Ile His Ser Ile His Ser Val Lys Phe Asn Ser 
    530                 535                 540             


<210>  5378
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  5378

Met Leu Ser Ser Phe Leu Ser Pro Gln Asn Gly Thr Trp Ala Asp Thr 
1               5                   10                  15      


Phe Ser Leu Leu Leu Ala Leu Ala Val Ala Leu Tyr Leu Gly Tyr Tyr 
            20                  25                  30          


Trp Ala Cys Val Leu Gln Arg Pro Arg Leu Val Ala Gly Pro Gln Phe 
        35                  40                  45              


Leu Ala Phe Leu Glu Pro His Cys Ser Ile Thr Thr Glu Thr Phe Tyr 
    50                  55                  60                  


Pro Thr Leu Trp Cys Phe Glu Gly Arg Leu Gln Ser Ile Phe Gln Val 
65                  70                  75                  80  


Leu Leu Gln Ser Gln Pro Leu Val Leu Tyr Gln Ser Asp Ile Leu Gln 
                85                  90                  95      


Thr Pro Asp Gly Gly Gln Leu Leu Leu Asp Trp Ala Lys Gln Pro Asp 
            100                 105                 110         


Ser Ser Gln Asp Pro Asp Pro Thr Thr Gln Pro Ile Val Leu Leu Leu 
        115                 120                 125             


Pro Gly Ile Thr Gly Ser Ser Gln Glu Thr Tyr Val Leu His Leu Val 
    130                 135                 140                 


Asn Gln Ala Leu Arg Asp Gly Tyr Gln Ala Val Val Phe Asn Asn Arg 
145                 150                 155                 160 


Gly Cys Arg Gly Glu Glu Leu Arg Thr His Arg Ala Phe Cys Ala Ser 
                165                 170                 175     


Asn Thr Glu Asp Leu Glu Thr Val Val Asn His Ile Lys His Arg Tyr 
            180                 185                 190         


Pro Gln Ala Pro Leu Leu Ala Val Gly Ile Ser Phe Gly Gly Ile Leu 
        195                 200                 205             


Val Leu Asn His Leu Ala Gln Ala Arg Gln Ala Ala Gly Leu Val Ala 
    210                 215                 220                 


Ala Leu Thr Leu Ser Ala Cys Trp Asp Ser Phe Glu Thr Thr Arg Ser 
225                 230                 235                 240 


Leu Glu Thr Pro Leu Asn Ser Leu Leu Phe Asn Gln Pro Leu Thr Ala 
                245                 250                 255     


Gly Leu Cys Gln Leu Val Glu Arg Asn Arg Lys Val Ile Glu Lys Val 
            260                 265                 270         


Val Asp Ile Asp Phe Val Leu Gln Ala Arg Thr Ile Arg Gln Phe Asp 
        275                 280                 285             


Glu Arg Tyr Thr Ser Val Ala Phe Gly Tyr Gln Asp Cys Val Thr Tyr 
    290                 295                 300                 


Tyr Lys Ala Ala Ser Pro Arg Thr Lys Ile Asp Ala Ile Arg Ile Pro 
305                 310                 315                 320 


Val Leu Tyr Leu Ser Ala Ala Asp Asp Pro Phe Ser Pro Val Cys Ala 
                325                 330                 335     


Leu Pro Ile Gln Ala Ala Gln His Ser Pro Tyr Val Ala Leu Leu Ile 
            340                 345                 350         


Thr Ala Arg Gly Gly His Ile Gly Phe Leu Glu Gly Leu Leu Pro Trp 
        355                 360                 365             


Gln His Trp Tyr Met Ser Arg Leu Leu His Gln Tyr Ala Lys Ala Ile 
    370                 375                 380                 


Phe Gln Asp Pro Glu Gly Leu Pro Asp Leu Arg Ala Leu Leu Pro Ser 
385                 390                 395                 400 


Glu Asp Arg Asn Ser 
                405 


<210>  5379
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  5379

Met Leu Pro Arg Ala Ala Trp Ser Leu Val Leu Arg Lys Gly Gly Gly 
1               5                   10                  15      


Gly Arg Arg Gly Met His Ser Ser Glu Gly Thr Thr Arg Gly Gly Gly 
            20                  25                  30          


Lys Met Ser Pro Tyr Thr Asn Cys Tyr Ala Gln Arg Tyr Tyr Pro Met 
        35                  40                  45              


Pro Glu Glu Pro Phe Cys Thr Glu Leu Asn Ala Glu Glu Gln Ala Leu 
    50                  55                  60                  


Lys Glu Lys Glu Lys Gly Ser Trp Thr Gln Leu Thr His Ala Glu Lys 
65                  70                  75                  80  


Val Ala Leu Tyr Arg Leu Gln Phe Asn Glu Thr Phe Ala Glu Met Asn 
                85                  90                  95      


Arg Arg Ser Asn Glu Trp Lys Thr Val Met Gly Cys Val Phe Phe Phe 
            100                 105                 110         


Ile Gly Phe Ala Ala Leu Val Ile Trp Trp Gln Arg Val Tyr Val Phe 
        115                 120                 125             


Pro Pro Lys Pro Ile Thr Leu Thr Asp Glu Arg Lys Ala Gln Gln Leu 
    130                 135                 140                 


Gln Arg Met Leu Asp Met Lys Val Asn Pro Val Gln Gly Leu Ala Ser 
145                 150                 155                 160 


Arg Trp Asp Tyr Glu Lys Lys Gln Trp Lys Lys 
                165                 170     


<210>  5380
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  5380

Met Tyr Leu Arg Arg Ala Val Ser Lys Thr Leu Ala Leu Pro Leu Arg 
1               5                   10                  15      


Ala Pro Pro Asn Pro Ala Pro Leu Gly Lys Asp Ala Ser Leu Arg Arg 
            20                  25                  30          


Met Ser Ser Asn Arg Phe Pro Gly Ser Ser Gly Ser Asn Met Ile Tyr 
        35                  40                  45              


Tyr Leu Val Val Gly Val Thr Val Ser Ala Gly Gly Tyr Tyr Ala Tyr 
    50                  55                  60                  


Lys Thr Val Thr Ser Asp Gln Ala Lys His Thr Glu His Lys Thr Asn 
65                  70                  75                  80  


Leu Lys Glu Lys Thr Lys Ala Glu Ile His Pro Phe Gln Gly Glu Lys 
                85                  90                  95      


Glu Asn Val Ala Glu Thr Glu Lys Ala Ser Ser Glu Ala Pro Glu Glu 
            100                 105                 110         


Leu Ile Val Glu Ala Glu Val Val Asp Ala Glu Glu Ser Pro Ser Ala 
        115                 120                 125             


Thr Val Val Val Ile Lys Glu Ala Ser Ala Cys Pro Gly His Val Glu 
    130                 135                 140                 


Ala Ala Pro Glu Thr Thr Ala Val Ser Ala Glu Thr Gly Pro Glu Val 
145                 150                 155                 160 


Thr Asp Ala Ala Ala Arg Glu Thr Thr Glu Val Asn Pro Glu Thr Thr 
                165                 170                 175     


Pro Glu Val Thr Asn Ala Ala Leu Asp Glu Ala Val Thr Ile Asp Asn 
            180                 185                 190         


Asp Lys Asp Thr Thr Lys Asn Glu Thr Ser Asp Glu Tyr Ala Glu Leu 
        195                 200                 205             


Glu Glu Glu Asn Ser Pro Ala Glu Ser Glu Ser Ser Ala Gly Asp Asp 
    210                 215                 220                 


Leu Gln Glu Glu Ala Ser Val Gly Ser Glu Ala Ala Ser Ala Gln Gly 
225                 230                 235                 240 


<210>  5381
<211>  385
<212>  PRT
<213>  Homo sapiens

<400>  5381

Met Tyr Ala Lys Gly Gly Lys Gly Ser Ala Val Pro Ser Asp Ser Gln 
1               5                   10                  15      


Ala Arg Glu Lys Leu Ala Leu Tyr Val Tyr Glu Tyr Leu Leu His Ile 
            20                  25                  30          


Gly Ala Gln Lys Ser Ala Gln Thr Phe Leu Ser Glu Ile Arg Trp Glu 
        35                  40                  45              


Lys Asn Ile Thr Leu Gly Glu Pro Pro Gly Phe Leu His Ser Trp Trp 
    50                  55                  60                  


Cys Val Phe Trp Asp Leu Tyr Cys Ala Ala Pro Asp Arg Arg Glu Ala 
65                  70                  75                  80  


Cys Glu His Ser Gly Glu Ala Lys Ala Phe Gln Asp Tyr Ser Ala Ala 
                85                  90                  95      


Ala Ala Pro Ser Pro Val Met Gly Ser Met Ala Pro Gly Asp Thr Met 
            100                 105                 110         


Ala Ala Gly Ser Met Ala Ala Gly Phe Phe Gln Gly Pro Pro Gly Ser 
        115                 120                 125             


Gln Pro Ser Pro His Asn Pro Asn Ala Pro Met Met Gly Pro His Gly 
    130                 135                 140                 


Gln Pro Phe Met Ser Pro Arg Phe Pro Gly Gly Pro Arg Pro Thr Leu 
145                 150                 155                 160 


Arg Met Pro Ser Gln Pro Pro Ala Gly Leu Pro Gly Ser Gln Pro Leu 
                165                 170                 175     


Leu Pro Gly Ala Met Glu Pro Ser Pro Arg Ala Gln Gly His Pro Ser 
            180                 185                 190         


Met Gly Gly Pro Met Gln Arg Val Thr Pro Pro Arg Gly Met Ala Ser 
        195                 200                 205             


Val Gly Pro Gln Ser Tyr Gly Gly Gly Met Arg Pro Pro Pro Asn Ser 
    210                 215                 220                 


Leu Ala Gly Pro Gly Leu Pro Ala Met Asn Met Gly Pro Gly Val Arg 
225                 230                 235                 240 


Gly Pro Trp Ala Ser Pro Ser Gly Asn Ser Ile Pro Tyr Ser Ser Ser 
                245                 250                 255     


Ser Pro Gly Ser Tyr Thr Gly Pro Pro Gly Gly Gly Gly Pro Pro Gly 
            260                 265                 270         


Thr Pro Ile Met Pro Ser Pro Gly Asp Ser Thr Asn Ser Ser Glu Asn 
        275                 280                 285             


Met Tyr Thr Ile Met Asn Pro Ile Gly Gln Gly Ala Gly Arg Ala Asn 
    290                 295                 300                 


Phe Pro Leu Gly Pro Gly Pro Glu Gly Pro Met Ala Ala Met Ser Ala 
305                 310                 315                 320 


Met Glu Pro His His Val Asn Gly Ser Leu Gly Ser Gly Asp Met Asp 
                325                 330                 335     


Gly Leu Pro Lys Ser Ser Pro Gly Ala Val Ala Gly Leu Ser Asn Ala 
            340                 345                 350         


Pro Gly Thr Pro Arg Asp Asp Gly Glu Met Ala Ala Ala Gly Thr Phe 
        355                 360                 365             


Leu His Pro Phe Pro Ser Glu Ser Tyr Ser Pro Gly Met Thr Met Ser 
    370                 375                 380                 


Val 
385 


<210>  5382
<211>  1089
<212>  PRT
<213>  Homo sapiens

<400>  5382

Met Gln Lys Ala Ser Val Leu Leu Phe Leu Ala Trp Val Cys Phe Leu 
1               5                   10                  15      


Phe Tyr Ala Gly Ile Ala Leu Phe Thr Ser Gly Phe Leu Leu Thr Arg 
            20                  25                  30          


Leu Glu Leu Thr Asn His Ser Ser Cys Gln Glu Pro Pro Gly Pro Gly 
        35                  40                  45              


Ser Leu Pro Trp Gly Ser Gln Gly Lys Pro Gly Ala Cys Trp Met Ala 
    50                  55                  60                  


Ser Arg Phe Ser Arg Val Val Leu Val Leu Ile Asp Ala Leu Arg Phe 
65                  70                  75                  80  


Asp Phe Ala Gln Pro Gln His Ser His Val Pro Arg Glu Pro Pro Val 
                85                  90                  95      


Ser Leu Pro Phe Leu Gly Lys Leu Ser Ser Leu Gln Arg Ile Leu Glu 
            100                 105                 110         


Ile Gln Pro His His Ala Arg Leu Tyr Arg Ser Gln Val Asp Pro Pro 
        115                 120                 125             


Thr Thr Thr Met Gln Arg Leu Lys Ala Leu Thr Thr Gly Ser Leu Pro 
    130                 135                 140                 


Thr Phe Ile Asp Ala Gly Ser Asn Phe Ala Ser His Ala Ile Val Glu 
145                 150                 155                 160 


Asp Asn Leu Ile Lys Gln Leu Thr Ser Ala Gly Arg Arg Val Val Phe 
                165                 170                 175     


Met Gly Asp Asp Thr Trp Lys Asp Leu Phe Pro Gly Ala Phe Ser Lys 
            180                 185                 190         


Ala Phe Phe Phe Pro Ser Phe Asn Val Arg Asp Leu Asp Thr Val Asp 
        195                 200                 205             


Asn Gly Ile Leu Glu His Leu Tyr Pro Thr Met Asp Ser Gly Glu Trp 
    210                 215                 220                 


Asp Val Leu Ile Ala His Phe Leu Gly Val Asp His Cys Gly His Lys 
225                 230                 235                 240 


His Gly Pro His His Pro Glu Met Ala Lys Lys Leu Ser Gln Met Asp 
                245                 250                 255     


Gln Val Ile Gln Gly Leu Val Glu Arg Leu Glu Asn Asp Thr Leu Leu 
            260                 265                 270         


Val Val Ala Gly Asp His Gly Met Thr Thr Asn Gly Asp His Gly Gly 
        275                 280                 285             


Asp Ser Glu Leu Glu Val Ser Ala Ala Leu Phe Leu Tyr Ser Pro Thr 
    290                 295                 300                 


Ala Val Phe Pro Ser Thr Pro Pro Glu Glu Pro Glu Val Ile Pro Gln 
305                 310                 315                 320 


Val Ser Leu Val Pro Thr Leu Ala Leu Leu Leu Gly Leu Pro Ile Pro 
                325                 330                 335     


Phe Gly Asn Ile Gly Glu Val Met Ala Glu Leu Phe Ser Gly Gly Glu 
            340                 345                 350         


Asp Ser Gln Pro His Ser Ser Ala Leu Ala Gln Ala Ser Ala Leu His 
        355                 360                 365             


Leu Asn Ala Gln Gln Val Ser Arg Phe Leu His Thr Tyr Ser Ala Ala 
    370                 375                 380                 


Thr Gln Asp Leu Gln Ala Lys Glu Leu His Gln Leu Gln Asn Leu Phe 
385                 390                 395                 400 


Ser Lys Ala Ser Ala Asp Tyr Gln Trp Leu Leu Gln Ser Pro Lys Gly 
                405                 410                 415     


Ala Glu Ala Thr Leu Pro Thr Val Ile Ala Glu Leu Gln Gln Phe Leu 
            420                 425                 430         


Arg Gly Ala Arg Ala Met Cys Ile Glu Ser Trp Ala Arg Phe Ser Leu 
        435                 440                 445             


Val Arg Met Ala Gly Gly Thr Ala Leu Leu Ala Ala Ser Cys Phe Ile 
    450                 455                 460                 


Cys Leu Leu Ala Ser Gln Trp Ala Ile Ser Pro Gly Phe Pro Phe Cys 
465                 470                 475                 480 


Pro Leu Leu Leu Thr Pro Val Ala Trp Gly Leu Val Gly Ala Ile Ala 
                485                 490                 495     


Tyr Ala Gly Leu Leu Gly Thr Ile Glu Leu Lys Leu Asp Leu Val Leu 
            500                 505                 510         


Leu Gly Ala Val Ala Ala Val Ser Ser Phe Leu Pro Phe Leu Trp Lys 
        515                 520                 525             


Ala Trp Ala Gly Trp Gly Ser Lys Arg Pro Leu Ala Thr Leu Phe Pro 
    530                 535                 540                 


Ile Pro Gly Pro Val Leu Leu Leu Leu Leu Phe Arg Leu Ala Val Phe 
545                 550                 555                 560 


Phe Ser Asp Ser Phe Val Val Ala Glu Ala Arg Ala Thr Pro Phe Leu 
                565                 570                 575     


Leu Gly Ser Phe Ile Leu Leu Leu Val Val Gln Leu His Trp Glu Gly 
            580                 585                 590         


Gln Leu Leu Pro Pro Lys Leu Leu Thr Met Pro Arg Leu Gly Thr Ser 
        595                 600                 605             


Ala Thr Thr Asn Pro Pro Arg His Asn Gly Ala Tyr Ala Leu Arg Leu 
    610                 615                 620                 


Gly Ile Gly Leu Leu Leu Cys Thr Arg Leu Ala Gly Leu Phe His Arg 
625                 630                 635                 640 


Cys Pro Glu Glu Thr Pro Val Cys His Ser Ser Pro Trp Leu Ser Pro 
                645                 650                 655     


Leu Ala Ser Met Val Gly Gly Arg Ala Lys Asn Leu Trp Tyr Gly Ala 
            660                 665                 670         


Cys Val Ala Ala Leu Val Ala Leu Leu Ala Ala Val Arg Leu Trp Leu 
        675                 680                 685             


Arg Arg Tyr Gly Asn Leu Lys Ser Pro Glu Pro Pro Met Leu Phe Val 
    690                 695                 700                 


Arg Trp Gly Leu Pro Leu Met Ala Leu Gly Thr Ala Ala Tyr Trp Ala 
705                 710                 715                 720 


Leu Ala Ser Gly Ala Asp Glu Ala Pro Pro Arg Leu Arg Val Leu Val 
                725                 730                 735     


Ser Gly Ala Ser Met Val Leu Pro Arg Ala Val Ala Gly Leu Ala Ala 
            740                 745                 750         


Ser Gly Leu Ala Leu Leu Leu Trp Lys Pro Val Thr Val Leu Val Lys 
        755                 760                 765             


Ala Gly Ala Gly Ala Pro Arg Thr Arg Thr Val Leu Thr Pro Phe Ser 
    770                 775                 780                 


Gly Pro Pro Thr Ser Gln Ala Asp Leu Asp Tyr Val Val Pro Gln Ile 
785                 790                 795                 800 


Tyr Arg His Met Gln Glu Glu Phe Arg Gly Arg Leu Glu Arg Thr Lys 
                805                 810                 815     


Ser Gln Gly Pro Leu Thr Val Ala Ala Tyr Gln Leu Gly Ser Val Tyr 
            820                 825                 830         


Ser Ala Ala Met Val Thr Ala Leu Thr Leu Leu Ala Phe Pro Leu Leu 
        835                 840                 845             


Leu Leu His Ala Glu Arg Ile Ser Leu Val Phe Leu Leu Leu Phe Leu 
    850                 855                 860                 


Gln Ser Phe Leu Leu Leu His Leu Leu Ala Ala Gly Ile Pro Val Thr 
865                 870                 875                 880 


Thr Pro Gly Pro Phe Thr Val Pro Trp Gln Ala Val Ser Ala Trp Ala 
                885                 890                 895     


Leu Met Ala Thr Gln Thr Phe Tyr Ser Thr Gly His Gln Pro Val Phe 
            900                 905                 910         


Pro Ala Ile His Trp His Ala Ala Phe Val Gly Phe Pro Glu Gly His 
        915                 920                 925             


Gly Ser Cys Thr Trp Leu Pro Ala Leu Leu Val Gly Ala Asn Thr Phe 
    930                 935                 940                 


Ala Ser His Leu Leu Phe Ala Val Gly Cys Pro Leu Leu Leu Leu Trp 
945                 950                 955                 960 


Pro Phe Leu Cys Glu Ser Gln Gly Leu Arg Lys Arg Gln Gln Pro Pro 
                965                 970                 975     


Gly Asn Glu Ala Asp Ala Arg Val Arg Pro Glu Glu Glu Glu Glu Pro 
            980                 985                 990         


Leu Met Glu Met Arg Leu Arg Asp  Ala Pro Gln His Phe  Tyr Ala Ala 
        995                 1000                 1005             


Leu Leu  Gln Leu Gly Leu Lys  Tyr Leu Phe Ile Leu  Gly Ile Gln 
    1010                 1015                 1020             


Ile Leu  Ala Cys Ala Leu Ala  Ala Ser Ile Leu Arg  Arg His Leu 
    1025                 1030                 1035             


Met Val  Trp Lys Val Phe Ala  Pro Lys Phe Ile Phe  Glu Ala Val 
    1040                 1045                 1050             


Gly Phe  Ile Val Ser Ser Val  Gly Leu Leu Leu Gly  Ile Ala Leu 
    1055                 1060                 1065             


Val Met  Arg Val Asp Gly Ala  Val Ser Ser Trp Phe  Arg Gln Leu 
    1070                 1075                 1080             


Phe Leu  Ala Gln Gln Arg 
    1085                 


<210>  5383
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  5383

Met Thr Leu Phe His Phe Gly Asn Cys Phe Ala Leu Ala Tyr Phe Pro 
1               5                   10                  15      


Tyr Phe Ile Thr Tyr Lys Cys Ser Gly Leu Ser Glu Tyr Asn Ala Phe 
            20                  25                  30          


Trp Lys Cys Val Gln Ala Gly Val Thr Tyr Leu Phe Val Gln Leu Cys 
        35                  40                  45              


Lys Met Leu Phe Leu Ala Thr Phe Phe Pro Thr Trp Glu Gly Gly Ile 
    50                  55                  60                  


Tyr Asp Phe Ile Gly Glu Phe Met Lys Ala Ser Val Asp Val Ala Asp 
65                  70                  75                  80  


Leu Ile Gly Leu Asn Leu Val Met Ser Arg Asn Ala Gly Lys Gly Glu 
                85                  90                  95      


Tyr Lys Ile Met Val Ala Ala Leu Gly Trp Ala Thr Ala Glu Leu Ile 
            100                 105                 110         


Met Ser Arg Cys Ile Pro Leu Trp Val Gly Ala Arg Gly Ile Glu Phe 
        115                 120                 125             


Asp Trp Lys Tyr Ile Gln Met Ser Ile Asp Ser Asn Ile Ser Leu Val 
    130                 135                 140                 


His Tyr Ile Val Ala Ser Ala Gln Val Trp Met Ile Thr Arg Tyr Asp 
145                 150                 155                 160 


Leu Tyr His Thr Phe Arg Pro Ala Val Leu Leu Leu Met Phe Leu Ser 
                165                 170                 175     


Val Tyr Lys Ala Phe Val Met Glu Thr Phe Val His Leu Cys Ser Leu 
            180                 185                 190         


Gly Ser Trp Ala Ala Leu Leu Ala Arg Ala Val Val Thr Gly Leu Leu 
        195                 200                 205             


Ala Leu Ser Thr Leu Ala Leu Tyr Val Ala Val Val Asn Val His Ser 
    210                 215                 220                 


<210>  5384
<211>  534
<212>  PRT
<213>  Homo sapiens

<400>  5384

Met Gln Ala Ala Arg Val Asp Tyr Ile Ala Pro Trp Trp Val Val Trp 
1               5                   10                  15      


Leu His Ser Val Pro His Val Gly Leu Arg Leu Gln Pro Val Asn Ser 
            20                  25                  30          


Thr Phe Ser Pro Gly Asp Glu Ser Tyr Gln Glu Ser Leu Leu Phe Leu 
        35                  40                  45              


Gly Leu Val Ala Ala Val Cys Leu Gly Leu Asn Leu Ile Phe Leu Val 
    50                  55                  60                  


Ala Tyr Leu Val Cys Ala Cys His Cys Arg Arg Asp Asp Ala Val Gln 
65                  70                  75                  80  


Thr Lys Gln His His Ser Cys Cys Ile Thr Trp Thr Ala Val Val Ala 
                85                  90                  95      


Gly Leu Ile Cys Cys Ala Ala Val Gly Val Gly Phe Tyr Gly Asn Ser 
            100                 105                 110         


Glu Thr Asn Asp Gly Ala Tyr Gln Leu Met Tyr Ser Leu Asp Asp Ala 
        115                 120                 125             


Asn His Thr Phe Ser Gly Ile Asp Ala Leu Val Ser Gly Thr Thr Gln 
    130                 135                 140                 


Lys Met Lys Val Asp Leu Glu Gln His Leu Ala Arg Leu Ser Glu Ile 
145                 150                 155                 160 


Phe Ala Ala Arg Gly Asp Tyr Leu Gln Thr Leu Lys Phe Ile Gln Gln 
                165                 170                 175     


Met Ala Gly Ser Val Val Val Gln Leu Ser Gly Leu Pro Val Trp Arg 
            180                 185                 190         


Glu Val Thr Met Glu Leu Thr Lys Leu Ser Asp Gln Thr Gly Tyr Val 
        195                 200                 205             


Glu Tyr Tyr Arg Trp Leu Ser Tyr Leu Leu Leu Phe Ile Leu Asp Leu 
    210                 215                 220                 


Val Ile Cys Leu Ile Ala Cys Leu Gly Leu Ala Lys Arg Ser Lys Cys 
225                 230                 235                 240 


Leu Leu Ala Ser Met Leu Cys Cys Gly Ala Leu Ser Leu Leu Leu Ser 
                245                 250                 255     


Trp Ala Ser Leu Ala Ala Asp Gly Ser Ala Ala Val Ala Thr Ser Asp 
            260                 265                 270         


Phe Cys Val Ala Pro Asp Thr Phe Ile Leu Asn Val Thr Glu Gly Gln 
        275                 280                 285             


Ile Ser Thr Glu Val Thr Arg Tyr Tyr Leu Tyr Cys Ser Gln Ser Gly 
    290                 295                 300                 


Ser Ser Pro Phe Gln Gln Thr Leu Thr Thr Phe Gln Arg Ala Leu Thr 
305                 310                 315                 320 


Thr Met Gln Ile Gln Val Ala Gly Leu Leu Gln Phe Ala Val Pro Leu 
                325                 330                 335     


Phe Ser Thr Ala Glu Glu Asp Leu Leu Ala Ile Gln Leu Leu Leu Asn 
            340                 345                 350         


Ser Ser Glu Ser Ser Leu His Gln Leu Thr Ala Met Val Asp Cys Arg 
        355                 360                 365             


Gly Leu His Lys Asp Tyr Leu Asp Ala Leu Ala Gly Ile Cys Tyr Asp 
    370                 375                 380                 


Gly Leu Gln Gly Leu Leu Tyr Leu Gly Leu Phe Ser Phe Leu Ala Ala 
385                 390                 395                 400 


Leu Ala Phe Ser Thr Met Ile Cys Ala Gly Pro Arg Ala Trp Lys His 
                405                 410                 415     


Phe Thr Thr Arg Asn Arg Asp Tyr Asp Asp Ile Asp Asp Asp Asp Pro 
            420                 425                 430         


Phe Asn Pro Gln Ala Trp Arg Met Ala Ala His Ser Pro Pro Arg Gly 
        435                 440                 445             


Gln Leu His Ser Phe Cys Ser Tyr Ser Ser Gly Leu Gly Ser Gln Thr 
    450                 455                 460                 


Ser Leu Gln Pro Pro Ala Gln Thr Ile Ser Asn Ala Pro Val Ser Glu 
465                 470                 475                 480 


Tyr Met Asn Gln Ala Met Leu Phe Gly Arg Asn Pro Arg Tyr Glu Asn 
                485                 490                 495     


Val Pro Leu Ile Gly Arg Ala Ser Pro Pro Pro Thr Tyr Ser Pro Ser 
            500                 505                 510         


Met Arg Ala Thr Tyr Leu Ser Val Ala Asp Glu His Leu Arg His Tyr 
        515                 520                 525             


Gly Asn Gln Phe Pro Ala 
    530                 


<210>  5385
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  5385

Met Leu Ser Ser Arg Ala Glu Ala Ala Met Thr Ala Ala Asp Arg Ala 
1               5                   10                  15      


Ile Gln Arg Phe Leu Arg Thr Gly Ala Ala Val Arg Tyr Lys Val Met 
            20                  25                  30          


Lys Asn Trp Gly Val Ile Gly Gly Ile Ala Ala Ala Leu Ala Ala Gly 
        35                  40                  45              


Ile Tyr Val Ile Trp Gly Pro Ile Thr Glu Arg Lys Lys Arg Arg Lys 
    50                  55                  60                  


Gly Leu Val Pro Gly Leu Val Asn Leu Gly Asn Thr Cys Phe Met Asn 
65                  70                  75                  80  


Ser Leu Leu Gln Gly Leu Ser Ala Cys Pro Ala Phe Ile Arg Trp Leu 
                85                  90                  95      


Glu Glu Phe Thr Ser Gln Tyr Ser Arg Asp Gln Lys Glu Pro Pro Ser 
            100                 105                 110         


His Gln Tyr Leu Ser Leu Thr Leu Leu His Leu Leu Lys Ala Leu Ser 
        115                 120                 125             


Cys Gln Glu Val Thr Asp Asp Glu Val Leu Asp Ala Ser Cys Leu Leu 
    130                 135                 140                 


Asp Val Leu Arg Met Tyr Arg Trp Gln Ile Ser Ser Phe Glu Glu Gln 
145                 150                 155                 160 


Asp Ala His Glu Leu Phe His Val Ile Thr Ser Ser Leu Glu Asp Glu 
                165                 170                 175     


Arg Asp Arg Gln Pro Arg Val Thr His Leu Phe Asp Val His Ser Leu 
            180                 185                 190         


Glu Gln Gln Ser Glu Ile Thr Pro Lys Gln Ile Thr Cys Arg Thr Arg 
        195                 200                 205             


Gly Ser Pro His Pro Thr Ser Asn His Trp Lys Ser Gln His Pro Phe 
    210                 215                 220                 


His Gly Arg Leu Thr Ser Asn Met Val Cys Lys His Cys Glu His Gln 
225                 230                 235                 240 


Ser Pro Val Arg Phe Asp Thr Phe Asp Ser Leu Ser Leu Ser Ile Pro 
                245                 250                 255     


Ala Ala Thr Trp Gly His Pro Leu Thr Leu Asp His Cys Leu His His 
            260                 265                 270         


Phe Ile Ser Ser Glu Ser Val Arg Asp Val Val Cys Asp Asn Cys Thr 
        275                 280                 285             


Lys Ile Glu Ala Lys Gly Thr Leu Asn Gly Glu Lys Val Glu His Gln 
    290                 295                 300                 


Arg Thr Thr Phe Val Lys Gln Leu Lys Leu Gly Lys Leu Pro Gln Cys 
305                 310                 315                 320 


Leu Cys Ile His Leu Gln Arg Leu Ser Trp Ser Ser His Gly Thr Pro 
                325                 330                 335     


Leu Lys Arg His Glu His Val Gln Phe Asn Glu Phe Leu Met Met Asp 
            340                 345                 350         


Ile Tyr Lys Tyr His Leu Leu Gly His Lys Pro Ser Gln His Asn Pro 
        355                 360                 365             


Lys Leu Asn Lys Asn Pro Gly Pro Thr Leu Glu Leu Gln Asp Gly Pro 
    370                 375                 380                 


Gly Ala Pro Thr Pro Val Leu Asn Gln Pro Gly Ala Pro Lys Thr Gln 
385                 390                 395                 400 


Ile Phe Met Asn Gly Ala Cys Ser Pro Ser Leu Leu Pro Thr Leu Ser 
                405                 410                 415     


Ala Pro Met Pro Phe Pro Leu Pro Val Val Pro Asp Tyr Ser Ser Ser 
            420                 425                 430         


Thr Tyr Leu Phe Arg Leu Met Ala Val Val Val His His Gly Asp Met 
        435                 440                 445             


His Ser Gly His Phe Val Thr Tyr Arg Arg Ser Pro Pro Ser Ala Arg 
    450                 455                 460                 


Asn Pro Leu Ser Thr Ser Asn Gln Trp Leu Trp Val Ser Asp Asp Thr 
465                 470                 475                 480 


Val Arg Lys Ala Ser Leu Gln Glu Val Leu Ser Ser Ser Ala Tyr Leu 
                485                 490                 495     


Leu Phe Tyr Glu Arg Val Leu Ser Arg Met Gln His Gln Ser Gln Glu 
            500                 505                 510         


Cys Lys Ser Glu Glu 
        515         


<210>  5386
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  5386

Met Val Arg Ile Gln Arg Arg Lys Leu Leu Ala Ser Cys Leu Cys Val 
1               5                   10                  15      


Thr Ala Thr Val Phe Leu Leu Val Thr Leu Gln Val Met Val Glu Leu 
            20                  25                  30          


Gly Lys Phe Glu Arg Lys Glu Phe Lys Ser Ser Ser Leu Gln Asp Gly 
        35                  40                  45              


His Thr Lys Met Glu Glu Ala Pro Thr His Leu Asn Ser Phe Leu Lys 
    50                  55                  60                  


Lys Glu Gly Leu Thr Phe Asn Arg Lys Arg Lys Trp Glu Leu Asp Ser 
65                  70                  75                  80  


Tyr Pro Ile Met Leu Trp Trp Ser Pro Leu Thr Gly Glu Thr Gly Arg 
                85                  90                  95      


Leu Gly Gln Cys Gly Ala Asp Ala Cys Phe Phe Thr Ile Asn Arg Thr 
            100                 105                 110         


Tyr Leu His His His Met Thr Lys Ala Phe Leu Phe Tyr Gly Thr Asp 
        115                 120                 125             


Phe Asn Ile Asp Ser Leu Pro Leu Pro Arg Lys Ala His His Asp Trp 
    130                 135                 140                 


Ala Val Phe His Glu Glu Ser Pro Lys Asn Asn Tyr Lys Leu Phe His 
145                 150                 155                 160 


Lys Pro Val Ile Thr Leu Phe Asn Tyr Thr Ala Thr Phe Ser Arg His 
                165                 170                 175     


Ser His Leu Pro Leu Thr Thr Gln Tyr Leu Glu Ser Ile Glu Val Leu 
            180                 185                 190         


Lys Ser Leu Arg Tyr Leu Val Pro Leu Gln Ser Lys Asn Lys Leu Arg 
        195                 200                 205             


Lys Arg Leu Ala Pro Leu Val Tyr Val Gln Ser Asp Cys Asp Pro Pro 
    210                 215                 220                 


Ser Asp Arg Asp Ser Tyr Val Arg Glu Leu Met Thr Tyr Ile Glu Val 
225                 230                 235                 240 


Asp Ser Tyr Gly Glu Cys Leu Arg Asn Lys Asp Leu Pro Gln Gln Leu 
                245                 250                 255     


Lys Asn Pro Ala Ser Met Asp Ala Asp Gly Phe Tyr Arg Ile Ile Ala 
            260                 265                 270         


Gln Tyr Lys Phe Ile Leu Ala Phe Glu Asn Ala Val Cys Asp Asp Tyr 
        275                 280                 285             


Ile Thr Glu Lys Phe Trp Arg Pro Leu Lys Leu Gly Val Val Pro Val 
    290                 295                 300                 


Tyr Tyr Gly Ser Pro Ser Ile Thr Asp Trp Leu Pro Ser Asn Lys Ser 
305                 310                 315                 320 


Ala Ile Leu Val Ser Glu Phe Ser His Pro Arg Glu Leu Ala Ser Tyr 
                325                 330                 335     


Ile Arg Arg Leu Asp Ser Asp Asp Arg Leu Tyr Glu Ala Tyr Val Glu 
            340                 345                 350         


Trp Lys Leu Lys Gly Glu Ile Ser Asn Gln Arg Leu Leu Thr Ala Leu 
        355                 360                 365             


Arg Glu Arg Lys Trp Gly Val Gln Asp Val Asn Gln Asp Asn Tyr Ile 
    370                 375                 380                 


Asp Ala Phe Glu Cys Met Val Cys Thr Lys Val Trp Ala Asn Ile Arg 
385                 390                 395                 400 


Leu Gln Glu Lys Gly Leu Pro Pro Lys Arg Trp Glu Ala Glu Asp Thr 
                405                 410                 415     


His Leu Ser Cys Pro Glu Pro Thr Val Phe Ala Phe Ser Pro Leu Arg 
            420                 425                 430         


Thr Pro Pro Leu Ser Ser Leu Arg Glu Met Trp Ile Ser Ser Phe Glu 
        435                 440                 445             


Gln Ser Lys Lys Glu Ala Gln Ala Leu Arg Trp Leu Val Asp Arg Asn 
    450                 455                 460                 


Gln Asn Phe Ser Ser Gln Glu Phe Trp Gly Leu Val Phe Lys Asp 
465                 470                 475                 


<210>  5387
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  5387

Met Ala Pro Lys Pro Gly Ala Glu Trp Ser Thr Ala Leu Ser His Leu 
1               5                   10                  15      


Val Leu Gly Val Val Ser Leu His Ala Ala Val Ser Thr Ala Glu Ala 
            20                  25                  30          


Ser Arg Gly Ala Ala Ala Gly Phe Leu Leu Gln Val Leu Ala Ala Thr 
        35                  40                  45              


Thr Thr Leu Ala Pro Gly Leu Ser Thr His Glu Asp Cys Leu Ala Gly 
    50                  55                  60                  


Ala Trp Val Ala Thr Val Ile Gly Leu Pro Leu Leu Ala Phe Asp Phe 
65                  70                  75                  80  


His Trp Val Asn Gly Asp Arg Ser Ser Ala Asn Leu Leu Leu Gly Gly 
                85                  90                  95      


Gly Met Val Leu Ala Val Ala Gly Gly His Leu Gly Pro Glu Gly Arg 
            100                 105                 110         


Ser Val Ala Gly Gln Ala Met Leu Leu Val Val Ala Val Thr Ile Leu 
        115                 120                 125             


Ile Val Ala Val Phe Thr Ala Asn Thr Tyr Gly Met Trp Gly Gly Ala 
    130                 135                 140                 


Met Leu Gly Val Ala Gly Leu Leu Ser Arg Leu Glu Glu Asp Arg Leu 
145                 150                 155                 160 


Leu Leu Leu Pro Lys Glu Asp Val Cys Arg Trp Ala Leu Ala Val Gly 
                165                 170                 175     


Ser Trp Ala Tyr Cys Arg Ala Leu His Thr Gln Arg Leu Gln Trp Glu 
            180                 185                 190         


<210>  5388
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  5388

Met Glu Gly Ala Glu Leu Ala Gly Lys Ile Leu Ser Thr Trp Leu Thr 
1               5                   10                  15      


Leu Val Leu Gly Phe Ile Leu Leu Pro Ser Val Phe Gly Val Ser Leu 
            20                  25                  30          


Gly Ile Ser Glu Ile Tyr Met Lys Ile Leu Val Lys Thr Leu Glu Trp 
        35                  40                  45              


Ala Thr Ile Arg Ile Glu Lys Gly Thr Pro Lys Glu Ser Ile Leu Lys 
    50                  55                  60                  


Asn Ser Ala Ser Val Gly Ile Ile Gln Arg Asp Glu Ser Pro Met Glu 
65                  70                  75                  80  


Lys Gly Leu Ser Gly Leu Arg Gly Arg Asp Phe Glu Leu Ser Asp Val 
                85                  90                  95      


Phe Tyr Phe Ser Lys Lys Gly Leu Glu Ala Ile Val Glu Asp Glu Val 
            100                 105                 110         


Thr Gln Arg Phe Ser Ser Glu Glu Leu Val Ser Trp Asn Leu Leu Thr 
        115                 120                 125             


Arg Thr Asn Val Asn Phe Gln Tyr Ile Ser Leu Arg Leu Thr Met Val 
    130                 135                 140                 


Trp Val Leu Gly Val Ile Val Arg Tyr Cys Val Leu Leu Pro Leu Arg 
145                 150                 155                 160 


Val Thr Leu Ala Phe Ile Gly Ile Ser Leu Leu Val Ile Gly Thr Thr 
                165                 170                 175     


Leu Val Gly Gln Leu Pro Asp Ser Ser Leu Lys Asn Trp Leu Ser Glu 
            180                 185                 190         


Leu Val His Leu Thr Cys Cys Arg Ile Cys Val Arg Ala Leu Ser Gly 
        195                 200                 205             


Thr Ile His Tyr His Asn Lys Gln Tyr Arg Pro Gln Lys Gly Gly Ile 
    210                 215                 220                 


Cys Val Ala Asn His Thr Ser Pro Ile Asp Val Leu Ile Leu Thr Thr 
225                 230                 235                 240 


Asp Gly Cys Tyr Ala Met Val Gly Gln Val His Gly Gly Leu Met Gly 
                245                 250                 255     


Ile Ile Gln Arg Ala Met Val Lys Ala Cys Pro His Val Trp Phe Glu 
            260                 265                 270         


Arg Ser Glu Met Lys Asp Arg His Leu Val Thr Lys Arg Leu Lys Glu 
        275                 280                 285             


His Ile Ala Asp Lys Lys Lys Leu Pro Ile Leu Ile Phe Pro Glu Gly 
    290                 295                 300                 


Thr Cys Ile Asn Asn Thr Ser Val Met Met Phe Lys Lys Gly Ser Phe 
305                 310                 315                 320 


Glu Ile Gly Gly Thr Ile His Pro Val Ala Ile Lys Tyr Asn Pro Gln 
                325                 330                 335     


Phe Gly Asp Ala Phe Trp Asn Ser Ser Lys Tyr Asn Met Val Ser Tyr 
            340                 345                 350         


Leu Leu Arg Met Met Thr Ser Trp Ala Ile Val Cys Asp Val Trp Tyr 
        355                 360                 365             


Met Pro Pro Met Thr Arg Glu Glu Gly Glu Asp Ala Val Gln Phe Ala 
    370                 375                 380                 


Asn Arg Val Lys Ser Ala Ile Ala Ile Gln Gly Gly Leu Thr Glu Leu 
385                 390                 395                 400 


Pro Trp Asp Gly Gly Leu Lys Arg Ala Lys Val Lys Asp Ile Phe Lys 
                405                 410                 415     


Glu Glu Gln Gln Lys Asn Tyr Ser Lys Met Ile Val Gly Asn Gly Ser 
            420                 425                 430         


Leu Ser 
        


<210>  5389
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  5389

Met Glu Leu Gly Gly His Trp Asp Met Asn Ser Ala Pro Arg Leu Val 
1               5                   10                  15      


Ser Glu Thr Ala Glu Arg Lys Gln Glu Gln Lys Thr Gly Thr Glu Ala 
            20                  25                  30          


Glu Ala Ala Asp Ser Gly Ala Val Gly Ala Arg Arg Phe Leu Leu Cys 
        35                  40                  45              


Leu Tyr Leu Val Gly Phe Leu Asp Leu Phe Gly Val Ser Met Val Val 
    50                  55                  60                  


Pro Leu Leu Ser Leu His Val Lys Ser Leu Gly Ala Ser Pro Thr Val 
65                  70                  75                  80  


Ala Gly Ile Val Gly Ser Ser Tyr Gly Ile Leu Gln Leu Phe Ser Ser 
                85                  90                  95      


Thr Leu Val Gly Cys Trp Ser Asp Val Val Gly Arg Arg Ser Ser Leu 
            100                 105                 110         


Leu Ala Cys Ile Leu Leu Ser Ala Leu Gly Tyr Leu Leu Leu Gly Ala 
        115                 120                 125             


Ala Thr Asn Val Phe Leu Phe Val Leu Ala Arg Val Pro Ala Gly Ile 
    130                 135                 140                 


Phe Lys His Thr Leu Ser Ile Ser Arg Ala Leu Leu Ser Asp Val Val 
145                 150                 155                 160 


Pro Glu Lys Glu Arg Pro Leu Val Ile Gly His Phe Asn Thr Ala Ser 
                165                 170                 175     


Gly Val Gly Phe Ile Leu Gly Pro Val Val Gly Gly Tyr Leu Thr Glu 
            180                 185                 190         


Leu Glu Asp Gly Phe Tyr Leu Thr Ala Phe Ile Cys Phe Leu Val Phe 
        195                 200                 205             


Ile Leu Asn Ala Gly Leu Val Trp Phe Phe Pro Trp Arg Glu Ala Lys 
    210                 215                 220                 


Pro Gly Ser Thr Glu Lys Gly Leu Pro Leu Arg Lys Thr His Val Leu 
225                 230                 235                 240 


Leu Gly Arg Ser His Asp Thr Val Gln Glu Ala Ala Thr Ser Arg Arg 
                245                 250                 255     


Ala Arg Ala Ser Lys Lys Thr Ala Gln Pro Trp Val Glu Val Val Leu 
            260                 265                 270         


Ala Leu Arg Asn Met Lys Asn Leu Leu Phe Ser Glu Met Trp Asp Ile 
        275                 280                 285             


Phe Leu Val Arg Leu Leu Met Ala Met Ala Val Met Leu Tyr Tyr Ser 
    290                 295                 300                 


Asn Phe Val Leu Ala Leu Glu Glu Arg Phe Gly Val Arg Pro Lys Val 
305                 310                 315                 320 


Thr Gly Tyr Leu Ile Ser Tyr Ser Ser Met Leu Gly Ala Val Ala Gly 
                325                 330                 335     


Leu Ala Leu Gly Pro Ile Leu Arg Leu Tyr Lys His Asn Ser Gln Ala 
            340                 345                 350         


Leu Leu Leu His Ser Ser Ile Leu Thr Cys Thr Leu Leu Leu Leu Tyr 
        355                 360                 365             


Ser Leu Ala Pro Thr Met Gly Ala Val Val Leu Ser Ser Thr Leu Leu 
    370                 375                 380                 


Ser Phe Ser Thr Ala Ile Gly Arg Thr Cys Ile Thr Asp Leu Gln Leu 
385                 390                 395                 400 


Thr Val Gly Gly Ala Gln Ala Ser Gly Thr Leu Ile Gly Val Gly Gln 
                405                 410                 415     


Ser Val Thr Ala Val Gly Arg Ile Ile Ala Pro Leu Leu Ser Gly Val 
            420                 425                 430         


Ala Gln Glu Val Ser Pro Cys Gly Pro Pro Ser Leu Gly Ala Val Leu 
        435                 440                 445             


Ala Leu Val Ala Ile Phe Ile Met Ser Leu Asn Lys Arg His Ser Ser 
    450                 455                 460                 


Gly Asp Gly Asn Ser Lys Leu Lys Ser Glu 
465                 470                 


<210>  5390
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  5390

Met Pro Ala Ser Gln Ser Arg Ala Arg Ala Arg Asp Arg Asn Asn Val 
1               5                   10                  15      


Leu Asn Arg Ala Glu Phe Leu Ser Leu Asn Gln Pro Pro Lys Gly Gly 
            20                  25                  30          


Pro Glu Pro Arg Ser Ser Gly Arg Lys Ala Ser Gly Pro Ser Ala Gln 
        35                  40                  45              


Pro Pro Pro Ala Gly Asp Gly Ala Arg Glu Arg Arg Gln Ser Gln Gln 
    50                  55                  60                  


Leu Pro Glu Glu Asp Cys Met Gln Leu Asn Pro Ser Phe Lys Gly Ile 
65                  70                  75                  80  


Ala Phe Asn Ser Leu Leu Ala Ile Asp Ile Cys Met Ser Lys Arg Leu 
                85                  90                  95      


Gly Val Cys Ala Gly Arg Ala Ala Ser Trp Ala Ser Ala Arg Ser Met 
            100                 105                 110         


Val Lys Leu Ile Gly Ile Thr Gly His Gly Ile Pro Trp Ile Gly Gly 
        115                 120                 125             


Thr Ile Leu Cys Leu Val Lys Ser Ser Thr Leu Ala Gly Gln Glu Val 
    130                 135                 140                 


Leu Met Asn Leu Leu Leu Ala Leu Leu Leu Asp Ile Met Thr Val Ala 
145                 150                 155                 160 


Gly Val Gln Lys Leu Ile Lys Arg Arg Gly Pro Tyr Glu Thr Ser Pro 
                165                 170                 175     


Ser Leu Leu Asp Tyr Leu Thr Met Asp Ile Tyr Ala Phe Pro Ala Gly 
            180                 185                 190         


His Ala Ser Arg Ala Ala Met Val Ser Lys Phe Phe Leu Ser His Leu 
        195                 200                 205             


Val Leu Ala Val Pro Leu Arg Val Leu Leu Val Leu Trp Ala Leu Cys 
    210                 215                 220                 


Val Gly Leu Ser Arg Val Met Ile Gly Arg His His Val Thr Asp Val 
225                 230                 235                 240 


Leu Ser Gly Phe Val Ile Gly Tyr Leu Gln Phe Arg Leu Val Glu Leu 
                245                 250                 255     


Val Trp Met Pro Ser Ser Thr Cys Gln Met Leu Ile Ser Ala Trp 
            260                 265                 270     


<210>  5391
<211>  705
<212>  PRT
<213>  Homo sapiens

<400>  5391

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys 
        35                  40                  45              


Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr 
    50                  55                  60                  


His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys 
65                  70                  75                  80  


Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp 
                85                  90                  95      


Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly 
            100                 105                 110         


Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser 
        115                 120                 125             


Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val 
    130                 135                 140                 


Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr 
145                 150                 155                 160 


Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr 
                165                 170                 175     


Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro 
            180                 185                 190         


Ala Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu 
        195                 200                 205             


Val Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp 
    210                 215                 220                 


Asn Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr 
225                 230                 235                 240 


Gly Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu 
                245                 250                 255     


Cys Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile 
            260                 265                 270         


Cys Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala 
        275                 280                 285             


Ala Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro 
    290                 295                 300                 


Cys Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly 
305                 310                 315                 320 


Asp Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr 
                325                 330                 335     


Val Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu 
            340                 345                 350         


Cys Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu 
        355                 360                 365             


Trp Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu 
    370                 375                 380                 


Thr Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser 
385                 390                 395                 400 


Gly Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu 
                405                 410                 415     


Gly Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu 
            420                 425                 430         


Trp Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr 
        435                 440                 445             


Ile His Lys Arg Trp Ala Leu Val Trp Leu Ala Cys Leu Leu Phe Ala 
    450                 455                 460                 


Ala Ala Leu Ser Leu Ile Leu Leu Leu Lys Lys Asp His Ala Lys Gly 
465                 470                 475                 480 


Trp Leu Arg Leu Leu Lys Gln Asp Val Arg Ser Gly Ala Ala Ala Arg 
                485                 490                 495     


Gly Arg Ala Ala Leu Leu Leu Tyr Ser Ala Asp Asp Ser Gly Phe Glu 
            500                 505                 510         


Arg Leu Val Gly Ala Leu Ala Ser Ala Leu Cys Gln Leu Pro Leu Arg 
        515                 520                 525             


Val Ala Val Asp Leu Trp Ser Arg Arg Glu Leu Ser Ala Gln Gly Pro 
    530                 535                 540                 


Val Ala Trp Phe His Ala Gln Arg Arg Gln Thr Leu Gln Glu Gly Gly 
545                 550                 555                 560 


Val Val Val Leu Leu Phe Ser Pro Gly Ala Val Ala Leu Cys Ser Glu 
                565                 570                 575     


Trp Leu Gln Asp Gly Val Ser Gly Pro Gly Ala His Gly Pro His Asp 
            580                 585                 590         


Ala Phe Arg Ala Ser Leu Ser Cys Val Leu Pro Asp Phe Leu Gln Gly 
        595                 600                 605             


Arg Ala Pro Gly Ser Tyr Val Gly Ala Cys Phe Asp Arg Leu Leu His 
    610                 615                 620                 


Pro Asp Ala Val Pro Ala Leu Phe Arg Thr Val Pro Val Phe Thr Leu 
625                 630                 635                 640 


Pro Ser Gln Leu Pro Asp Phe Leu Gly Ala Leu Gln Gln Pro Arg Ala 
                645                 650                 655     


Pro Arg Ser Gly Arg Leu Gln Glu Arg Ala Glu Gln Val Ser Arg Ala 
            660                 665                 670         


Leu Gln Pro Ala Leu Asp Ser Tyr Phe His Pro Pro Gly Thr Pro Ala 
        675                 680                 685             


Pro Gly Arg Gly Val Gly Pro Gly Ala Gly Pro Gly Ala Gly Asp Gly 
    690                 695                 700                 


Thr 
705 


<210>  5392
<211>  668
<212>  PRT
<213>  Homo sapiens

<400>  5392

Met Thr Val Thr Tyr Ser Ser Lys Val Ala Asn Ala Thr Phe Phe Gly 
1               5                   10                  15      


Phe His Arg Leu Leu Leu Lys Trp Arg Gly Ser Ile Tyr Lys Leu Leu 
            20                  25                  30          


Tyr Arg Glu Phe Ile Val Phe Ala Val Leu Tyr Thr Ala Ile Ser Leu 
        35                  40                  45              


Val Tyr Arg Leu Leu Leu Thr Gly Val Gln Lys Arg Tyr Phe Glu Lys 
    50                  55                  60                  


Leu Ser Ile Tyr Cys Asp Arg Tyr Ala Glu Gln Ile Pro Val Thr Phe 
65                  70                  75                  80  


Val Leu Gly Phe Tyr Val Thr Leu Val Val Asn Arg Trp Trp Asn Gln 
                85                  90                  95      


Phe Val Asn Leu Pro Trp Pro Asp Arg Leu Met Phe Leu Ile Ser Ser 
            100                 105                 110         


Ser Val His Gly Ser Asp Glu His Gly Arg Leu Leu Arg Arg Thr Leu 
        115                 120                 125             


Met Arg Tyr Val Asn Leu Thr Ser Leu Leu Ile Phe Arg Ser Val Ser 
    130                 135                 140                 


Thr Ala Val Tyr Lys Arg Phe Pro Thr Met Asp His Val Val Glu Ala 
145                 150                 155                 160 


Gly Phe Met Thr Thr Asp Glu Arg Lys Leu Phe Asn His Leu Lys Ser 
                165                 170                 175     


Pro His Leu Lys Tyr Trp Val Pro Phe Ile Trp Phe Gly Asn Leu Ala 
            180                 185                 190         


Thr Lys Ala Arg Asn Glu Gly Arg Ile Arg Asp Ser Val Asp Leu Gln 
        195                 200                 205             


Ser Leu Met Thr Glu Met Asn Arg Tyr Arg Ser Trp Cys Ser Leu Leu 
    210                 215                 220                 


Phe Gly Tyr Asp Trp Val Gly Ile Pro Leu Val Tyr Thr Gln Val Val 
225                 230                 235                 240 


Thr Leu Ala Val Tyr Thr Phe Phe Phe Ala Cys Leu Ile Gly Arg Gln 
                245                 250                 255     


Phe Leu Asp Pro Thr Lys Gly Tyr Ala Gly His Asp Leu Asp Leu Tyr 
            260                 265                 270         


Ile Pro Ile Phe Thr Leu Leu Gln Phe Phe Phe Tyr Ala Gly Trp Leu 
        275                 280                 285             


Lys Val Ala Glu Gln Leu Ile Asn Pro Phe Gly Glu Asp Asp Asp Asp 
    290                 295                 300                 


Phe Glu Thr Asn Trp Cys Ile Asp Arg Asn Leu Gln Val Ser Leu Leu 
305                 310                 315                 320 


Ala Val Asp Glu Met His Met Ser Leu Pro Lys Met Lys Lys Asp Ile 
                325                 330                 335     


Tyr Trp Asp Asp Ser Ala Ala Arg Pro Pro Tyr Thr Leu Ala Ala Ala 
            340                 345                 350         


Asp Tyr Cys Ile Pro Ser Phe Leu Gly Ser Thr Val Gln Met Gly Leu 
        355                 360                 365             


Ser Gly Ser Asp Phe Pro Asp Glu Glu Trp Leu Trp Asp Tyr Glu Lys 
    370                 375                 380                 


His Gly His Arg His Ser Met Ile Arg Arg Val Lys Arg Phe Leu Ser 
385                 390                 395                 400 


Ala His Glu His Pro Ser Ser Pro Arg Arg Arg Ser Tyr Arg Arg Gln 
                405                 410                 415     


Thr Ser Asp Ser Ser Met Phe Leu Pro Arg Asp Asp Leu Ser Pro Ala 
            420                 425                 430         


Arg Asp Leu Leu Asp Val Pro Ser Arg Asn Pro Pro Arg Ala Ser Pro 
        435                 440                 445             


Thr Trp Lys Lys Ser Cys Phe Pro Glu Gly Ser Pro Thr Leu His Phe 
    450                 455                 460                 


Ser Met Gly Glu Leu Ser Thr Ile Arg Glu Thr Ser Gln Thr Ser Thr 
465                 470                 475                 480 


Leu Gln Ser Leu Thr Pro Gln Ser Ser Val Arg Thr Ser Pro Ile Lys 
                485                 490                 495     


Met Pro Leu Val Pro Glu Val Leu Ile Thr Ala Ala Glu Ala Pro Val 
            500                 505                 510         


Pro Thr Ser Gly Gly Tyr His His Asp Ser Ala Thr Ser Ile Leu Ser 
        515                 520                 525             


Ser Glu Phe Thr Gly Val Gln Pro Ser Lys Thr Glu Gln Gln Gln Gly 
    530                 535                 540                 


Pro Met Gly Ser Ile Leu Ser Pro Ser Glu Lys Glu Thr Pro Pro Gly 
545                 550                 555                 560 


Gly Pro Ser Pro Gln Thr Val Ser Ala Ser Ala Glu Glu Asn Ile Phe 
                565                 570                 575     


Asn Cys Glu Glu Asp Pro Gly Asp Thr Phe Leu Lys Arg Trp Ser Leu 
            580                 585                 590         


Pro Gly Phe Leu Gly Ser Ser His Thr Ser Leu Gly Asn Leu Ser Pro 
        595                 600                 605             


Asp Pro Met Ser Ser Gln Pro Ala Leu Leu Ile Asp Thr Glu Thr Ser 
    610                 615                 620                 


Ser Glu Ile Ser Gly Ile Asn Ile Val Ala Gly Ser Arg Val Ser Ser 
625                 630                 635                 640 


Asp Met Leu Tyr Leu Met Glu Asn Leu Asp Thr Lys Glu Thr Asp Ile 
                645                 650                 655     


Ile Glu Leu Asn Lys Glu Thr Glu Glu Ser Pro Lys 
            660                 665             


<210>  5393
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  5393

Met Leu Lys Lys Ile Ser Val Gly Val Ala Gly Asp Leu Asn Thr Val 
1               5                   10                  15      


Thr Met Lys Leu Gly Cys Val Leu Met Ala Trp Ala Leu Tyr Leu Ser 
            20                  25                  30          


Leu Gly Val Leu Trp Val Ala Gln Met Leu Leu Ala Ala Ser Phe Glu 
        35                  40                  45              


Thr Leu Gln Cys Glu Gly Pro Val Cys Thr Glu Glu Ser Ser Cys His 
    50                  55                  60                  


Thr Glu Asp Asp Leu Thr Asp Ala Arg Glu Ala Gly Phe Gln Val Lys 
65                  70                  75                  80  


Ala Tyr Thr Phe Ser Glu Pro Phe His Leu Ile Val Ser Tyr Asp Trp 
                85                  90                  95      


Leu Ile Leu Gln Gly Pro Ala Lys Pro Val Phe Glu Gly Asp Leu Leu 
            100                 105                 110         


Val Leu Arg Cys Gln Ala Trp Gln Asp Trp Pro Leu Thr Gln Val Thr 
        115                 120                 125             


Phe Tyr Arg Asp Gly Ser Ala Leu Gly Pro Pro Gly Pro Asn Arg Glu 
    130                 135                 140                 


Phe Ser Ile Thr Val Val Gln Lys Ala Asp Ser Gly His Tyr His Cys 
145                 150                 155                 160 


Ser Gly Ile Phe Gln Ser Pro Gly Pro Gly Ile Pro Glu Thr Ala Ser 
                165                 170                 175     


Val Val Ala Ile Thr Val Gln Glu Leu Phe Pro Ala Pro Ile Leu Arg 
            180                 185                 190         


Ala Val Pro Ser Ala Glu Pro Gln Ala Gly Ser Pro Met Thr Leu Ser 
        195                 200                 205             


Cys Gln Thr Lys Leu Pro Leu Gln Arg Ser Ala Ala Arg Leu Leu Phe 
    210                 215                 220                 


Ser Phe Tyr Lys Asp Gly Arg Ile Val Gln Ser Arg Gly Leu Ser Ser 
225                 230                 235                 240 


Glu Phe Gln Ile Pro Thr Ala Ser Glu Asp His Ser Gly Ser Tyr Trp 
                245                 250                 255     


Cys Glu Ala Ala Thr Glu Asp Asn Gln Val Trp Lys Gln Ser Pro Gln 
            260                 265                 270         


Leu Glu Ile Arg Val Gln Gly Ala Ser Ser Ser Ala Ala Pro Pro Thr 
        275                 280                 285             


Leu Asn Pro Ala Pro Gln Lys Ser Ala Ala Pro Gly Thr Ala Pro Glu 
    290                 295                 300                 


Glu Ala Pro Gly Pro Leu Pro Pro Pro Pro Thr Pro Ser Ser Glu Asp 
305                 310                 315                 320 


Pro Gly Phe Ser Ser Pro Leu Gly Met Pro Asp Pro His Leu Tyr His 
                325                 330                 335     


Gln Met Gly Leu Leu Leu Lys His Met Gln Asp Val Arg Val Leu Leu 
            340                 345                 350         


Gly His Leu Leu Met Glu Leu Arg Glu Leu Ser Gly His Arg Lys Pro 
        355                 360                 365             


Gly Thr Thr Lys Ala Thr Ala Glu 
    370                 375     


<210>  5394
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  5394

Met Ala Asp Leu His Arg Gln Leu Gln Glu Tyr Leu Ala Gln Gly Lys 
1               5                   10                  15      


Ala Gly Gly Pro Ala Ala Ala Glu Pro Leu Leu Ala Ala Glu Lys Ala 
            20                  25                  30          


Glu Glu Pro Gly Asp Arg Pro Ala Glu Glu Trp Leu Gly Arg Ala Gly 
        35                  40                  45              


Leu Arg Trp Thr Trp Ala Arg Ser Pro Ala Glu Ser Ala Ala Ala Gly 
    50                  55                  60                  


Leu Thr Cys Leu Pro Ser Val Thr Arg Gly Gln Arg Leu Ala Ala Gly 
65                  70                  75                  80  


Gly Gly Cys Leu Leu Leu Ala Ala Leu Cys Phe Gly Leu Ala Ala Leu 
                85                  90                  95      


Tyr Ala Pro Val Leu Leu Leu Arg Ala Arg Lys Phe Ala Leu Leu Trp 
            100                 105                 110         


Ser Leu Gly Ser Ala Leu Ala Leu Ala Gly Ser Ala Leu Leu Arg Gly 
        115                 120                 125             


Gly Ala Ala Cys Gly Arg Leu Leu Arg Cys Glu Glu Ala Pro Ser Arg 
    130                 135                 140                 


Pro Ala Leu Leu Tyr Met Ala Ala Leu Gly Ala Thr Leu Phe Ala Ala 
145                 150                 155                 160 


Leu Gly Leu Arg Ser Thr Leu Leu Thr Val Leu Gly Ala Gly Ala Gln 
                165                 170                 175     


Val Ala Ala Leu Leu Ala Ala Leu Val Gly Leu Leu Pro Trp Gly Gly 
            180                 185                 190         


Gly Thr Ala Leu Arg Leu Ala Leu Gly Arg Leu Gly Arg Gly Ala Gly 
        195                 200                 205             


Leu Ala Lys Val Leu Pro Val 
    210                 215 


<210>  5395
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  5395

Met Asp Leu Trp Pro Gly Ala Trp Met Leu Leu Leu Leu Leu Phe Leu 
1               5                   10                  15      


Leu Leu Leu Phe Leu Leu Pro Thr Leu Trp Phe Cys Ser Pro Ser Ala 
            20                  25                  30          


Lys Tyr Phe Phe Lys Met Ala Phe Tyr Asn Gly Trp Ile Leu Phe Leu 
        35                  40                  45              


Ala Val Leu Ala Ile Pro Val Cys Ala Val Arg Gly Arg Asn Val Glu 
    50                  55                  60                  


Asn Met Lys Ile Leu Arg Leu Met Leu Leu His Ile Lys Tyr Leu Tyr 
65                  70                  75                  80  


Gly Ile Arg Val Glu Val Arg Gly Ala His His Phe Pro Pro Ser Gln 
                85                  90                  95      


Pro Tyr Val Val Val Ser Asn His Gln Ser Ser Leu Asp Leu Leu Gly 
            100                 105                 110         


Met Met Glu Val Leu Pro Gly Arg Cys Val Pro Ile Ala Lys Arg Glu 
        115                 120                 125             


Leu Leu Trp Ala Gly Ser Ala Gly Leu Ala Cys Trp Leu Ala Gly Val 
    130                 135                 140                 


Ile Phe Ile Asp Arg Lys Arg Thr Gly Asp Ala Ile Ser Val Met Ser 
145                 150                 155                 160 


Glu Val Ala Gln Thr Leu Leu Thr Gln Asp Val Arg Val Trp Val Phe 
                165                 170                 175     


Pro Glu Gly Thr Arg Asn His Asn Gly Ser Met Leu Pro Phe Lys Arg 
            180                 185                 190         


Gly Ala Phe His Leu Ala Val Gln Ala Gln Val Pro Ile Val Pro Ile 
        195                 200                 205             


Val Met Ser Ser Tyr Gln Asp Phe Tyr Cys Lys Lys Glu Arg Arg Phe 
    210                 215                 220                 


Thr Ser Gly Gln Cys Gln Val Arg Val Leu Pro Pro Val Pro Thr Glu 
225                 230                 235                 240 


Gly Leu Thr Pro Asp Asp Val Pro Ala Leu Ala Asp Arg Val Arg His 
                245                 250                 255     


Ser Met Leu Thr Val Phe Arg Glu Ile Ser Thr Asp Gly Arg Gly Gly 
            260                 265                 270         


Gly Asp Tyr Leu Lys Lys Pro Gly Gly Gly Gly 
        275                 280             


<210>  5396
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  5396

Met Thr Lys Thr Ser Thr Cys Ile Tyr His Phe Leu Val Leu Ser Trp 
1               5                   10                  15      


Tyr Thr Phe Leu Asn Tyr Tyr Ile Ser Gln Glu Gly Lys Asp Glu Val 
            20                  25                  30          


Lys Pro Lys Ile Leu Ala Asn Gly Ala Arg Trp Lys Tyr Met Thr Leu 
        35                  40                  45              


Leu Asn Leu Leu Leu Gln Thr Ile Phe Tyr Gly Val Thr Cys Leu Asp 
    50                  55                  60                  


Asp Val Leu Lys Arg Thr Lys Gly Gly Lys Asp Ile Lys Phe Leu Thr 
65                  70                  75                  80  


Ala Phe Arg Asp Leu Leu Phe Thr Thr Leu Ala Phe Pro Val Ser Thr 
                85                  90                  95      


Phe Val Phe Leu Ala Phe Trp Ile Leu Phe Leu Tyr Asn Arg Asp Leu 
            100                 105                 110         


Ile Tyr Pro Lys Val Leu Asp Thr Val Ile Pro Val Trp Leu Asn His 
        115                 120                 125             


Ala Met His Thr Phe Ile Phe Pro Ile Thr Leu Ala Glu Val Val Leu 
    130                 135                 140                 


Arg Pro His Ser Tyr Pro Ser Lys Lys Thr Gly Leu Thr Leu Leu Ala 
145                 150                 155                 160 


Ala Ala Ser Ile Ala Tyr Ile Ser Arg Ile Leu Trp Leu Tyr Phe Glu 
                165                 170                 175     


Thr Gly Thr Trp Val Tyr Pro Val Phe Ala Lys Leu Ser Leu Leu Gly 
            180                 185                 190         


Leu Ala Ala Phe Phe Ser Leu Ser Tyr Val Phe Ile Ala Ser Ile Tyr 
        195                 200                 205             


Leu Leu Gly Glu Lys Leu Asn His Trp Lys Trp Gly Asp Met Arg Gln 
    210                 215                 220                 


Pro Arg Lys Lys Arg Lys 
225                 230 


<210>  5397
<211>  712
<212>  PRT
<213>  Homo sapiens

<400>  5397

Met Ala Ala Ala Gly Leu Val Ala Val Ala Ala Ala Ala Glu Tyr Ser 
1               5                   10                  15      


Gly Thr Val Ala Ser Gly Gly Asn Leu Pro Gly Val His Cys Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Gly Pro Gly Phe Gly Pro Gly Ser Trp Ser Arg Ser 
        35                  40                  45              


Leu Asp Arg Ala Leu Glu Glu Ala Ala Val Thr Gly Val Leu Ser Leu 
    50                  55                  60                  


Ser Gly Arg Lys Leu Arg Glu Phe Pro Arg Gly Ala Ala Asn His Asp 
65                  70                  75                  80  


Leu Thr Asp Thr Thr Arg Ala Asp Leu Ser Arg Asn Arg Leu Ser Glu 
                85                  90                  95      


Ile Pro Ile Glu Ala Cys His Phe Val Ser Leu Glu Asn Leu Asn Leu 
            100                 105                 110         


Tyr Gln Asn Cys Ile Arg Tyr Ile Pro Glu Ala Ile Leu Asn Leu Gln 
        115                 120                 125             


Ala Leu Thr Phe Leu Asn Ile Ser Arg Asn Gln Leu Ser Thr Leu Pro 
    130                 135                 140                 


Val His Leu Cys Asn Leu Pro Leu Lys Val Leu Ile Ala Ser Asn Asn 
145                 150                 155                 160 


Lys Leu Val Ser Leu Pro Glu Glu Ile Gly His Leu Arg His Leu Met 
                165                 170                 175     


Glu Leu Asp Val Ser Cys Asn Glu Ile Gln Thr Ile Pro Ser Gln Ile 
            180                 185                 190         


Gly Asn Leu Glu Ala Leu Arg Asp Leu Asn Val Arg Arg Asn His Leu 
        195                 200                 205             


Val His Leu Pro Glu Glu Leu Ala Glu Leu Pro Leu Ile Arg Leu Asp 
    210                 215                 220                 


Phe Ser Cys Asn Lys Ile Thr Thr Ile Pro Val Cys Tyr Arg Asn Leu 
225                 230                 235                 240 


Arg His Leu Gln Thr Ile Thr Leu Asp Asn Asn Pro Leu Gln Ser Pro 
                245                 250                 255     


Pro Ala Gln Ile Cys Ile Lys Gly Lys Val His Ile Phe Lys Tyr Leu 
            260                 265                 270         


Asn Ile Gln Ala Cys Lys Ile Ala Pro Asp Leu Pro Asp Tyr Asp Arg 
        275                 280                 285             


Arg Pro Leu Gly Phe Gly Ser Cys His Glu Glu Leu Tyr Ser Ser Arg 
    290                 295                 300                 


Pro Tyr Gly Ala Leu Asp Ser Gly Phe Asn Ser Val Asp Ser Gly Asp 
305                 310                 315                 320 


Lys Arg Trp Ser Gly Asn Glu Pro Thr Asp Glu Phe Ser Asp Leu Pro 
                325                 330                 335     


Leu Arg Val Ala Glu Ile Thr Lys Glu Gln Arg Leu Arg Arg Glu Ser 
            340                 345                 350         


Gln Tyr Gln Glu Asn Arg Gly Ser Leu Val Val Thr Asn Gly Gly Val 
        355                 360                 365             


Glu His Asp Leu Asp Gln Ile Asp Tyr Ile Asp Ser Cys Thr Ala Glu 
    370                 375                 380                 


Glu Glu Glu Ala Glu Val Arg Gln Pro Lys Gly Pro Asp Pro Asp Ser 
385                 390                 395                 400 


Leu Ser Ser Gln Phe Met Ala Tyr Ile Glu Gln Arg Arg Ile Ser His 
                405                 410                 415     


Glu Gly Ser Pro Val Lys Pro Val Ala Ile Arg Glu Phe Gln Lys Thr 
            420                 425                 430         


Glu Asp Met Arg Arg Tyr Leu His Gln Asn Arg Val Pro Ala Glu Pro 
        435                 440                 445             


Ser Ser Leu Leu Ser Leu Ser Ala Ser His Asn Gln Leu Ser His Thr 
    450                 455                 460                 


Asp Leu Glu Leu His Gln Arg Arg Glu Gln Leu Val Glu Arg Thr Arg 
465                 470                 475                 480 


Arg Glu Ala Gln Leu Ala Ala Leu Gln Tyr Glu Glu Glu Lys Ile Arg 
                485                 490                 495     


Thr Lys Gln Ile Gln Arg Asp Ala Val Leu Asp Phe Val Lys Gln Lys 
            500                 505                 510         


Ala Ser Gln Ser Pro Gln Lys Gln His Pro Leu Leu Asp Gly Val Asp 
        515                 520                 525             


Gly Glu Cys Pro Phe Pro Ser Arg Arg Ser Gln His Thr Asp Asp Ser 
    530                 535                 540                 


Ala Leu Cys Met Ser Leu Ser Gly Leu Asn Gln Val Gly Cys Ala Ala 
545                 550                 555                 560 


Thr Leu Pro His Ser Ser Ala Phe Thr Pro Leu Lys Ser Asp Asp Arg 
                565                 570                 575     


Pro Asn Ala Leu Leu Ser Ser Pro Ala Thr Glu Thr Val His His Ser 
            580                 585                 590         


Pro Ala Tyr Ser Phe Pro Ala Ala Ile Gln Arg Asn Gln Pro Gln Arg 
        595                 600                 605             


Pro Glu Ser Phe Leu Phe Arg Ala Gly Val Arg Ala Glu Thr Asn Lys 
    610                 615                 620                 


Gly His Ala Ser Pro Leu Pro Pro Ser Ala Ala Pro Thr Thr Asp Ser 
625                 630                 635                 640 


Thr Asp Ser Ile Thr Gly Gln Asn Ser Arg Gln Arg Glu Glu Glu Leu 
                645                 650                 655     


Glu Leu Ile Asp Gln Leu Arg Lys His Ile Glu Tyr Arg Leu Lys Val 
            660                 665                 670         


Ser Leu Pro Cys Asp Leu Gly Ala Ala Leu Thr Asp Gly Val Val Leu 
        675                 680                 685             


Cys His Leu Ala Asn His Val Arg Pro Arg Ser Val Pro Ser Ile His 
    690                 695                 700                 


Val Pro Ser Pro Ala Val Val Ser 
705                 710         


<210>  5398
<211>  1338
<212>  PRT
<213>  Homo sapiens

<400>  5398

Met Gly Ala Gly Gly Arg Arg Met Arg Gly Ala Pro Ala Arg Leu Leu 
1               5                   10                  15      


Leu Pro Leu Leu Pro Trp Leu Leu Leu Leu Leu Ala Pro Glu Ala Arg 
            20                  25                  30          


Gly Ala Pro Gly Cys Pro Leu Ser Ile Arg Ser Cys Lys Cys Ser Gly 
        35                  40                  45              


Glu Arg Pro Lys Gly Leu Ser Gly Gly Val Pro Gly Pro Ala Arg Arg 
    50                  55                  60                  


Arg Val Val Cys Ser Gly Gly Asp Leu Pro Glu Pro Pro Glu Pro Gly 
65                  70                  75                  80  


Leu Leu Pro Asn Gly Thr Val Thr Leu Leu Leu Ser Asn Asn Lys Ile 
                85                  90                  95      


Thr Gly Leu Arg Asn Gly Ser Phe Leu Gly Leu Ser Leu Leu Glu Lys 
            100                 105                 110         


Leu Asp Leu Arg Asn Asn Ile Ile Ser Thr Val Gln Pro Gly Ala Phe 
        115                 120                 125             


Leu Gly Leu Gly Glu Leu Lys Arg Leu Asp Leu Ser Asn Asn Arg Ile 
    130                 135                 140                 


Gly Cys Leu Thr Ser Glu Thr Phe Gln Gly Leu Pro Arg Leu Leu Arg 
145                 150                 155                 160 


Leu Asn Ile Ser Gly Asn Ile Phe Ser Ser Leu Gln Pro Gly Val Phe 
                165                 170                 175     


Asp Glu Leu Pro Ala Leu Lys Val Val Asp Leu Gly Thr Glu Phe Leu 
            180                 185                 190         


Thr Cys Asp Cys His Leu Arg Trp Leu Leu Pro Trp Ala Gln Asn Arg 
        195                 200                 205             


Ser Leu Gln Leu Ser Glu His Thr Leu Cys Ala Tyr Pro Ser Ala Leu 
    210                 215                 220                 


His Ala Gln Ala Leu Gly Ser Leu Gln Glu Ala Gln Leu Cys Cys Glu 
225                 230                 235                 240 


Gly Ala Leu Glu Leu His Thr His His Leu Ile Pro Ser Leu Arg Gln 
                245                 250                 255     


Val Val Phe Gln Gly Asp Arg Leu Pro Phe Gln Cys Ser Ala Ser Tyr 
            260                 265                 270         


Leu Gly Asn Asp Thr Arg Ile Arg Trp Tyr His Asn Arg Ala Pro Val 
        275                 280                 285             


Glu Gly Asp Glu Gln Ala Gly Ile Leu Leu Ala Glu Ser Leu Ile His 
    290                 295                 300                 


Asp Cys Thr Phe Ile Thr Ser Glu Leu Thr Leu Ser His Ile Gly Val 
305                 310                 315                 320 


Trp Ala Ser Gly Glu Trp Glu Cys Thr Val Ser Met Ala Gln Gly Asn 
                325                 330                 335     


Ala Ser Lys Lys Val Glu Ile Val Val Leu Glu Thr Ser Ala Ser Tyr 
            340                 345                 350         


Cys Pro Ala Glu Arg Val Ala Asn Asn Arg Gly Asp Phe Arg Trp Pro 
        355                 360                 365             


Arg Thr Leu Ala Gly Ile Thr Ala Tyr Gln Ser Cys Leu Gln Tyr Pro 
    370                 375                 380                 


Phe Thr Ser Val Pro Leu Gly Gly Gly Ala Pro Gly Thr Arg Ala Ser 
385                 390                 395                 400 


Arg Arg Cys Asp Arg Ala Gly Arg Trp Glu Pro Gly Asp Tyr Ser His 
                405                 410                 415     


Cys Leu Tyr Thr Asn Asp Ile Thr Arg Val Leu Tyr Thr Phe Val Leu 
            420                 425                 430         


Met Pro Ile Asn Ala Ser Asn Ala Leu Thr Leu Ala His Gln Leu Arg 
        435                 440                 445             


Val Tyr Thr Ala Glu Ala Ala Ser Phe Ser Asp Met Met Asp Val Val 
    450                 455                 460                 


Tyr Val Ala Gln Met Ile Gln Lys Phe Leu Gly Tyr Val Asp Gln Ile 
465                 470                 475                 480 


Lys Glu Leu Val Glu Val Met Val Asp Met Ala Ser Asn Leu Met Leu 
                485                 490                 495     


Val Asp Glu His Leu Leu Trp Leu Ala Gln Arg Glu Asp Lys Ala Cys 
            500                 505                 510         


Ser Arg Ile Val Gly Ala Leu Glu Arg Ile Gly Gly Ala Ala Leu Ser 
        515                 520                 525             


Pro His Ala Gln His Ile Ser Val Asn Ala Arg Asn Val Ala Leu Glu 
    530                 535                 540                 


Ala Tyr Leu Ile Lys Pro His Ser Tyr Val Gly Leu Thr Cys Thr Ala 
545                 550                 555                 560 


Phe Gln Arg Arg Glu Gly Gly Val Pro Gly Thr Arg Pro Gly Ser Pro 
                565                 570                 575     


Gly Gln Asn Pro Pro Pro Glu Pro Glu Pro Pro Ala Asp Gln Gln Leu 
            580                 585                 590         


Arg Phe Arg Cys Thr Thr Gly Arg Pro Asn Val Ser Leu Ser Ser Phe 
        595                 600                 605             


His Ile Lys Asn Ser Val Ala Leu Ala Ser Ile Gln Leu Pro Pro Ser 
    610                 615                 620                 


Leu Phe Ser Ser Leu Pro Ala Ala Leu Ala Pro Pro Val Pro Pro Asp 
625                 630                 635                 640 


Cys Thr Leu Gln Leu Leu Val Phe Arg Asn Gly Arg Leu Phe His Ser 
                645                 650                 655     


His Ser Asn Thr Ser Arg Pro Gly Ala Ala Gly Pro Gly Lys Arg Arg 
            660                 665                 670         


Gly Val Ala Thr Pro Val Ile Phe Ala Gly Thr Ser Gly Cys Gly Val 
        675                 680                 685             


Gly Asn Leu Thr Glu Pro Val Ala Val Ser Leu Arg His Trp Ala Glu 
    690                 695                 700                 


Gly Ala Glu Pro Val Ala Ala Trp Trp Ser Gln Glu Gly Pro Gly Glu 
705                 710                 715                 720 


Ala Gly Gly Trp Thr Ser Glu Gly Cys Gln Leu Arg Ser Ser Gln Pro 
                725                 730                 735     


Asn Val Ser Ala Leu His Cys Gln His Leu Gly Asn Val Ala Val Leu 
            740                 745                 750         


Met Glu Leu Ser Ala Phe Pro Arg Glu Val Gly Gly Ala Gly Ala Gly 
        755                 760                 765             


Leu His Pro Val Val Tyr Pro Cys Thr Ala Leu Leu Leu Leu Cys Leu 
    770                 775                 780                 


Phe Ala Thr Ile Ile Thr Tyr Ile Leu Asn His Ser Ser Ile Arg Val 
785                 790                 795                 800 


Ser Arg Lys Gly Trp His Met Leu Leu Asn Leu Cys Phe His Ile Ala 
                805                 810                 815     


Met Thr Ser Ala Val Phe Ala Gly Gly Ile Thr Leu Thr Asn Tyr Gln 
            820                 825                 830         


Met Val Cys Gln Ala Val Gly Ile Thr Leu His Tyr Ser Ser Leu Ser 
        835                 840                 845             


Thr Leu Leu Trp Met Gly Val Lys Ala Arg Val Leu His Lys Glu Leu 
    850                 855                 860                 


Thr Trp Arg Ala Pro Pro Pro Gln Glu Gly Asp Pro Ala Leu Pro Thr 
865                 870                 875                 880 


Pro Ser Pro Met Leu Arg Phe Tyr Leu Ile Ala Gly Gly Ile Pro Leu 
                885                 890                 895     


Ile Ile Cys Gly Ile Thr Ala Ala Val Asn Ile His Asn Tyr Arg Asp 
            900                 905                 910         


His Ser Pro Tyr Cys Trp Leu Val Trp Arg Pro Ser Leu Gly Ala Phe 
        915                 920                 925             


Tyr Ile Pro Val Ala Leu Ile Leu Leu Ile Thr Trp Ile Tyr Phe Leu 
    930                 935                 940                 


Cys Ala Gly Leu Arg Leu Arg Gly Pro Leu Ala Gln Asn Pro Lys Ala 
945                 950                 955                 960 


Gly Asn Ser Arg Ala Ser Leu Glu Ala Gly Glu Glu Leu Arg Gly Ser 
                965                 970                 975     


Thr Arg Leu Arg Gly Ser Gly Pro Leu Leu Ser Asp Ser Gly Ser Leu 
            980                 985                 990         


Leu Ala Thr Gly Ser Ala Arg Val  Gly Thr Pro Gly Pro  Pro Glu Asp 
        995                 1000                 1005             


Gly Asp  Ser Leu Tyr Ser Pro  Gly Val Gln Leu Gly  Ala Leu Val 
    1010                 1015                 1020             


Thr Thr  His Phe Leu Tyr Leu  Ala Met Trp Ala Cys  Gly Ala Leu 
    1025                 1030                 1035             


Ala Val  Ser Gln Arg Trp Leu  Pro Arg Val Val Cys  Ser Cys Leu 
    1040                 1045                 1050             


Tyr Gly  Val Ala Ala Ser Ala  Leu Gly Leu Phe Val  Phe Thr His 
    1055                 1060                 1065             


His Cys  Ala Arg Arg Arg Asp  Val Arg Ala Ser Trp  Arg Ala Cys 
    1070                 1075                 1080             


Cys Pro  Pro Ala Ser Pro Ala  Ala Pro His Ala Pro  Pro Arg Ala 
    1085                 1090                 1095             


Leu Pro  Ala Ala Ala Glu Asp  Gly Ser Pro Val Phe  Gly Glu Gly 
    1100                 1105                 1110             


Pro Pro  Ser Leu Lys Ser Ser  Pro Ser Gly Ser Ser  Gly His Pro 
    1115                 1120                 1125             


Leu Ala  Leu Gly Pro Cys Lys  Leu Thr Asn Leu Gln  Leu Ala Gln 
    1130                 1135                 1140             


Ser Gln  Val Cys Glu Ala Gly  Ala Ala Ala Gly Gly  Glu Gly Glu 
    1145                 1150                 1155             


Pro Glu  Pro Ala Gly Thr Arg  Gly Asn Leu Ala His  Arg His Pro 
    1160                 1165                 1170             


Asn Asn  Val His His Gly Arg  Arg Ala His Lys Ser  Arg Ala Lys 
    1175                 1180                 1185             


Gly His  Arg Ala Gly Glu Ala  Cys Gly Lys Asn Arg  Leu Lys Ala 
    1190                 1195                 1200             


Leu Arg  Gly Gly Ala Ala Gly  Ala Leu Glu Leu Leu  Ser Ser Glu 
    1205                 1210                 1215             


Ser Gly  Ser Leu His Asn Ser  Pro Thr Asp Ser Tyr  Leu Gly Ser 
    1220                 1225                 1230             


Ser Arg  Asn Ser Pro Gly Ala  Gly Leu Gln Leu Glu  Gly Glu Pro 
    1235                 1240                 1245             


Met Leu  Thr Pro Ser Glu Gly  Ser Asp Thr Ser Ala  Ala Pro Leu 
    1250                 1255                 1260             


Ser Glu  Ala Gly Arg Ala Gly  Gln Arg Arg Ser Ala  Ser Arg Asp 
    1265                 1270                 1275             


Ser Leu  Lys Gly Gly Gly Ala  Leu Glu Lys Glu Ser  His Arg Arg 
    1280                 1285                 1290             


Ser Tyr  Pro Leu Asn Ala Ala  Ser Leu Asn Gly Ala  Pro Lys Gly 
    1295                 1300                 1305             


Gly Lys  Tyr Asp Asp Val Thr  Leu Met Gly Ala Glu  Val Ala Ser 
    1310                 1315                 1320             


Gly Gly  Cys Met Lys Thr Gly  Leu Trp Lys Ser Glu  Thr Thr Val 
    1325                 1330                 1335             


<210>  5399
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  5399

Met Ala Leu Pro Pro Gly Pro Ala Ala Leu Arg His Thr Leu Leu Leu 
1               5                   10                  15      


Leu Pro Ala Leu Leu Ser Ser Gly Trp Gly Glu Leu Glu Pro Gln Ile 
            20                  25                  30          


Asp Gly Gln Thr Trp Ala Glu Arg Ala Leu Arg Glu Asn Glu Arg His 
        35                  40                  45              


Ala Phe Thr Cys Arg Val Ala Gly Gly Pro Gly Thr Pro Arg Leu Ala 
    50                  55                  60                  


Trp Tyr Leu Asp Gly Gln Leu Gln Glu Ala Ser Thr Ser Arg Leu Leu 
65                  70                  75                  80  


Ser Val Gly Gly Glu Ala Phe Ser Gly Gly Thr Ser Thr Phe Thr Val 
                85                  90                  95      


Thr Ala His Arg Ala Gln His Glu Leu Asn Cys Ser Leu Gln Asp Pro 
            100                 105                 110         


Arg Ser Gly Arg Ser Ala Asn Ala Ser Val Ile Leu Asn Val Gln Phe 
        115                 120                 125             


Lys Pro Glu Ile Ala Gln Val Gly Ala Lys Tyr Gln Glu Ala Gln Gly 
    130                 135                 140                 


Pro Gly Leu Leu Val Val Leu Phe Ala Leu Val Arg Ala Asn Pro Pro 
145                 150                 155                 160 


Ala Asn Val Thr Trp Ile Asp Gln Asp Gly Pro Val Thr Val Asn Thr 
                165                 170                 175     


Ser Asp Phe Leu Val Leu Asp Ala Gln Asn Tyr Pro Trp Leu Thr Asn 
            180                 185                 190         


His Thr Val Gln Leu Gln Leu Arg Ser Leu Ala His Asn Leu Ser Val 
        195                 200                 205             


Val Ala Thr Asn Asp Val Gly Val Thr Ser Ala Ser Leu Pro Ala Pro 
    210                 215                 220                 


Gly Leu Leu Ala Thr Arg Val Glu Val Pro Leu Leu Gly Ile Val Val 
225                 230                 235                 240 


Ala Ala Gly Leu Ala Leu Gly Thr Leu Val Gly Phe Ser Thr Leu Val 
                245                 250                 255     


Ala Cys Leu Val Cys Arg Lys Glu Lys Lys Thr Lys Gly Pro Ser Arg 
            260                 265                 270         


His Pro Ser Leu Ile Ser Ser Asp Ser Asn Asn Leu Lys Leu Asn Asn 
        275                 280                 285             


Val Arg Leu Pro Arg Glu Asn Met Ser Leu Pro Ser Asn Leu Gln Leu 
    290                 295                 300                 


Asn Asp Leu Thr Pro Asp Ser Arg Ala Val Lys Pro Ala Asp Arg Gln 
305                 310                 315                 320 


Met Ala Gln Asn Asn Ser Arg Pro Glu Leu Leu Asp Pro Glu Pro Gly 
                325                 330                 335     


Gly Leu Leu Thr Ser Gln Gly Phe Ile Arg Leu Pro Val Leu Gly Tyr 
            340                 345                 350         


Ile Tyr Arg Val Ser Ser Val Ser Ser Asp Glu Ile Trp Leu 
        355                 360                 365     


<210>  5400
<211>  565
<212>  PRT
<213>  Homo sapiens

<400>  5400

Met Asn Tyr Glu Gly Ala Arg Ser Glu Arg Glu Asn His Ala Ala Asp 
1               5                   10                  15      


Asp Ser Glu Gly Gly Ala Leu Asp Met Cys Cys Ser Glu Arg Leu Pro 
            20                  25                  30          


Gly Leu Pro Gln Pro Ile Val Met Glu Ala Leu Asp Glu Ala Glu Gly 
        35                  40                  45              


Leu Gln Asp Ser Gln Arg Glu Met Pro Pro Pro Pro Pro Pro Ser Pro 
    50                  55                  60                  


Pro Ser Asp Pro Ala Gln Lys Pro Pro Pro Arg Gly Ala Gly Ser His 
65                  70                  75                  80  


Ser Leu Thr Val Arg Ser Ser Leu Cys Leu Phe Ala Ala Ser Gln Phe 
                85                  90                  95      


Leu Leu Ala Cys Gly Val Leu Trp Phe Ser Gly Tyr Gly His Ile Trp 
            100                 105                 110         


Ser Gln Asn Ala Thr Asn Leu Val Ser Ser Leu Leu Thr Leu Leu Lys 
        115                 120                 125             


Gln Leu Glu Pro Thr Ala Trp Leu Asp Ser Gly Thr Trp Gly Val Pro 
    130                 135                 140                 


Ser Leu Leu Leu Val Phe Leu Ser Val Gly Leu Val Leu Val Thr Thr 
145                 150                 155                 160 


Leu Val Trp His Leu Leu Arg Thr Pro Pro Glu Pro Pro Thr Pro Leu 
                165                 170                 175     


Pro Pro Glu Asp Arg Arg Gln Ser Val Ser Arg Gln Pro Ser Phe Thr 
            180                 185                 190         


Tyr Ser Glu Trp Met Glu Glu Lys Ile Glu Asp Asp Phe Leu Asp Leu 
        195                 200                 205             


Asp Pro Val Pro Glu Thr Pro Val Phe Asp Cys Val Met Asp Ile Lys 
    210                 215                 220                 


Pro Glu Ala Asp Pro Thr Ser Leu Thr Val Lys Ser Met Gly Leu Gln 
225                 230                 235                 240 


Glu Arg Arg Gly Ser Asn Val Ser Leu Thr Leu Asp Met Cys Thr Pro 
                245                 250                 255     


Gly Cys Asn Glu Glu Gly Phe Gly Tyr Leu Met Ser Pro Arg Glu Glu 
            260                 265                 270         


Ser Ala Arg Glu Tyr Leu Leu Ser Ala Ser Arg Val Leu Gln Ala Glu 
        275                 280                 285             


Glu Leu His Glu Lys Ala Leu Asp Pro Phe Leu Leu Gln Ala Glu Phe 
    290                 295                 300                 


Phe Glu Ile Pro Met Asn Phe Val Asp Pro Lys Glu Tyr Asp Ile Pro 
305                 310                 315                 320 


Gly Leu Val Arg Lys Asn Arg Tyr Lys Thr Ile Leu Pro Asn Pro His 
                325                 330                 335     


Ser Arg Val Cys Leu Thr Ser Pro Asp Pro Asp Asp Pro Leu Ser Ser 
            340                 345                 350         


Tyr Ile Asn Ala Asn Tyr Ile Arg Gly Tyr Gly Gly Glu Glu Lys Val 
        355                 360                 365             


Tyr Ile Ala Thr Gln Gly Pro Ile Val Ser Thr Val Ala Asp Phe Trp 
    370                 375                 380                 


Arg Met Val Trp Gln Glu His Thr Pro Ile Ile Val Met Ile Thr Asn 
385                 390                 395                 400 


Ile Glu Glu Met Asn Glu Lys Cys Thr Glu Tyr Trp Pro Glu Glu Gln 
                405                 410                 415     


Val Ala Tyr Asp Gly Val Glu Ile Thr Val Gln Lys Val Ile His Thr 
            420                 425                 430         


Glu Asp Tyr Arg Leu Arg Leu Ile Ser Leu Lys Ser Gly Thr Glu Glu 
        435                 440                 445             


Arg Gly Leu Lys His Tyr Trp Phe Thr Ser Trp Pro Asp Gln Lys Thr 
    450                 455                 460                 


Pro Asp Arg Ala Pro Pro Leu Leu His Leu Val Arg Glu Val Glu Glu 
465                 470                 475                 480 


Ala Ala Gln Gln Glu Gly Pro His Cys Ala Pro Ile Ile Val His Cys 
                485                 490                 495     


Ser Ala Gly Ile Gly Arg Thr Gly Cys Phe Ile Ala Thr Ser Ile Cys 
            500                 505                 510         


Cys Gln Gln Leu Arg Gln Glu Gly Val Val Asp Ile Leu Lys Thr Thr 
        515                 520                 525             


Cys Gln Leu Arg Gln Asp Arg Gly Gly Met Ile Gln Thr Cys Glu Gln 
    530                 535                 540                 


Tyr Gln Phe Val His His Val Met Ser Leu Tyr Glu Lys Gln Leu Ser 
545                 550                 555                 560 


His Gln Ser Pro Glu 
                565 


<210>  5401
<211>  797
<212>  PRT
<213>  Homo sapiens

<400>  5401

Met Ala Ser Cys Arg Ala Trp Asn Leu Arg Val Leu Val Ala Val Val 
1               5                   10                  15      


Cys Gly Leu Leu Thr Gly Ile Ile Leu Gly Leu Gly Ile Trp Arg Ile 
            20                  25                  30          


Val Ile Arg Ile Gln Arg Gly Lys Ser Thr Ser Ser Ser Ser Thr Pro 
        35                  40                  45              


Thr Glu Phe Cys Arg Asn Gly Gly Thr Trp Glu Asn Gly Arg Cys Ile 
    50                  55                  60                  


Cys Thr Glu Glu Trp Lys Gly Leu Arg Cys Thr Ile Ala Asn Phe Cys 
65                  70                  75                  80  


Glu Asn Ser Thr Tyr Met Gly Phe Thr Phe Ala Arg Ile Pro Val Gly 
                85                  90                  95      


Arg Tyr Gly Pro Ser Leu Gln Thr Cys Gly Lys Asp Thr Pro Asn Ala 
            100                 105                 110         


Gly Asn Pro Met Ala Val Arg Leu Cys Ser Leu Ser Leu Tyr Gly Glu 
        115                 120                 125             


Ile Glu Leu Gln Lys Val Thr Ile Gly Asn Cys Asn Glu Asn Leu Glu 
    130                 135                 140                 


Thr Leu Glu Lys Gln Val Lys Asp Val Thr Ala Pro Leu Asn Asn Ile 
145                 150                 155                 160 


Ser Ser Glu Val Gln Ile Leu Thr Ser Asp Ala Asn Lys Leu Thr Ala 
                165                 170                 175     


Glu Asn Ile Thr Ser Ala Thr Arg Val Val Gly Gln Ile Phe Asn Thr 
            180                 185                 190         


Ser Arg Asn Ala Ser Pro Glu Ala Lys Lys Val Ala Ile Val Thr Val 
        195                 200                 205             


Ser Gln Leu Leu Asp Ala Ser Glu Asp Ala Phe Gln Arg Val Ala Ala 
    210                 215                 220                 


Thr Ala Asn Asp Asp Ala Leu Thr Thr Leu Ile Glu Gln Met Glu Thr 
225                 230                 235                 240 


Tyr Ser Leu Ser Leu Gly Asn Gln Ser Val Val Glu Pro Asn Ile Ala 
                245                 250                 255     


Ile Gln Ser Ala Asn Phe Ser Ser Glu Asn Ala Val Gly Pro Ser Asn 
            260                 265                 270         


Val Arg Phe Ser Val Gln Lys Gly Ala Ser Ser Ser Leu Val Ser Ser 
        275                 280                 285             


Ser Thr Phe Ile His Thr Asn Val Asp Gly Leu Asn Pro Asp Ala Gln 
    290                 295                 300                 


Thr Glu Leu Gln Val Leu Leu Asn Met Thr Lys Asn Tyr Thr Lys Thr 
305                 310                 315                 320 


Cys Gly Phe Val Val Tyr Gln Asn Asp Lys Leu Phe Gln Ser Lys Thr 
                325                 330                 335     


Phe Thr Ala Lys Ser Asp Phe Ser Gln Lys Ile Ile Ser Ser Lys Thr 
            340                 345                 350         


Asp Glu Asn Glu Gln Asp Gln Ser Ala Ser Val Asp Met Val Phe Ser 
        355                 360                 365             


Pro Lys Tyr Asn Gln Lys Glu Phe Gln Leu Tyr Ser Tyr Ala Cys Val 
    370                 375                 380                 


Tyr Trp Asn Leu Ser Ala Lys Asp Trp Asp Thr Tyr Gly Cys Gln Lys 
385                 390                 395                 400 


Asp Lys Gly Thr Asp Gly Phe Leu Arg Cys Arg Cys Asn His Thr Thr 
                405                 410                 415     


Asn Phe Ala Val Leu Met Thr Phe Lys Lys Asp Tyr Gln Tyr Pro Lys 
            420                 425                 430         


Ser Leu Asp Ile Leu Ser Asn Val Gly Cys Ala Leu Ser Val Thr Gly 
        435                 440                 445             


Leu Ala Leu Thr Val Ile Phe Gln Ile Val Thr Arg Lys Val Arg Lys 
    450                 455                 460                 


Thr Ser Val Thr Trp Val Leu Val Asn Leu Cys Ile Ser Met Leu Ile 
465                 470                 475                 480 


Phe Asn Leu Leu Phe Val Phe Gly Ile Glu Asn Ser Asn Lys Asn Leu 
                485                 490                 495     


Gln Thr Ser Asp Gly Asp Ile Asn Asn Ile Asp Phe Asp Asn Asn Asp 
            500                 505                 510         


Ile Pro Arg Thr Asp Thr Ile Asn Ile Pro Asn Pro Met Cys Thr Ala 
        515                 520                 525             


Ile Ala Ala Leu Leu His Tyr Phe Leu Leu Val Thr Phe Thr Trp Asn 
    530                 535                 540                 


Ala Leu Ser Ala Ala Gln Leu Tyr Tyr Leu Leu Ile Arg Thr Met Lys 
545                 550                 555                 560 


Pro Leu Pro Arg His Phe Ile Leu Phe Ile Ser Leu Ile Gly Trp Gly 
                565                 570                 575     


Val Pro Ala Ile Val Val Ala Ile Thr Val Gly Val Ile Tyr Ser Gln 
            580                 585                 590         


Asn Gly Asn Asn Pro Gln Trp Glu Leu Asp Tyr Arg Gln Glu Lys Ile 
        595                 600                 605             


Cys Trp Leu Ala Ile Pro Glu Pro Asn Gly Val Ile Lys Ser Pro Leu 
    610                 615                 620                 


Leu Trp Ser Phe Ile Val Pro Val Thr Ile Ile Leu Ile Ser Asn Val 
625                 630                 635                 640 


Val Met Phe Ile Thr Ile Ser Ile Lys Val Leu Trp Lys Asn Asn Gln 
                645                 650                 655     


Asn Leu Thr Ser Thr Lys Lys Val Ser Ser Met Lys Lys Ile Val Ser 
            660                 665                 670         


Thr Leu Ser Val Ala Val Val Phe Gly Ile Thr Trp Ile Leu Ala Tyr 
        675                 680                 685             


Leu Met Leu Val Asn Asp Asp Ser Ile Arg Ile Val Phe Ser Tyr Ile 
    690                 695                 700                 


Phe Cys Leu Phe Asn Thr Thr Gln Gly Leu Gln Ile Phe Ile Leu Tyr 
705                 710                 715                 720 


Thr Val Arg Thr Lys Val Phe Gln Ser Glu Ala Ser Lys Val Leu Met 
                725                 730                 735     


Leu Leu Ser Ser Ile Gly Arg Arg Lys Ser Leu Pro Ser Val Thr Arg 
            740                 745                 750         


Pro Arg Leu Arg Val Lys Met Tyr Asn Phe Leu Arg Ser Leu Pro Thr 
        755                 760                 765             


Leu His Glu Arg Phe Arg Leu Leu Glu Thr Ser Pro Ser Thr Glu Glu 
    770                 775                 780                 


Ile Thr Leu Ser Glu Ser Asp Asn Ala Lys Glu Ser Ile 
785                 790                 795         


<210>  5402
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  5402

Met Ala Lys Gly Glu Gly Ala Glu Ser Gly Ser Ala Ala Gly Leu Leu 
1               5                   10                  15      


Pro Thr Ser Ile Leu Gln Ser Thr Glu Arg Pro Ala Gln Val Lys Lys 
            20                  25                  30          


Glu Pro Lys Lys Lys Lys Gln Gln Leu Ser Val Cys Asn Lys Leu Cys 
        35                  40                  45              


Tyr Ala Leu Gly Gly Ala Pro Tyr Gln Val Thr Gly Cys Ala Leu Gly 
    50                  55                  60                  


Phe Phe Leu Gln Ile Tyr Leu Leu Asp Val Ala Gln Val Gly Pro Phe 
65                  70                  75                  80  


Ser Ala Ser Ile Ile Leu Phe Val Gly Arg Ala Trp Asp Ala Ile Thr 
                85                  90                  95      


Asp Pro Leu Val Gly Leu Cys Ile Ser Lys Ser Pro Trp Thr Cys Leu 
            100                 105                 110         


Gly Arg Leu Met Pro Trp Ile Ile Phe Ser Thr Pro Leu Ala Val Ile 
        115                 120                 125             


Ala Tyr Phe Leu Ile Trp Phe Val Pro Asp Phe Pro His Gly Gln Thr 
    130                 135                 140                 


Tyr Trp Tyr Leu Leu Phe Tyr Cys Leu Phe Glu Thr Met Val Thr Cys 
145                 150                 155                 160 


Phe His Val Pro Tyr Ser Ala Leu Thr Met Phe Ile Ser Thr Glu Gln 
                165                 170                 175     


Thr Glu Arg Asp Ser Ala Thr Ala Tyr Arg Met Thr Val Glu Val Leu 
            180                 185                 190         


Gly Thr Val Leu Gly Thr Ala Ile Gln Gly Gln Ile Val Gly Gln Ala 
        195                 200                 205             


Asp Thr Pro Cys Phe Gln Asp Leu Asn Ser Ser Thr Val Ala Ser Gln 
    210                 215                 220                 


Ser Ala Asn His Thr His Gly Thr Thr Ser His Arg Glu Thr Gln Lys 
225                 230                 235                 240 


Ala Tyr Leu Leu Ala Ala Gly Val Ile Val Cys Ile Tyr Ile Ile Cys 
                245                 250                 255     


Ala Val Ile Leu Ile Leu Gly Val Arg Glu Gln Arg Glu Pro Tyr Glu 
            260                 265                 270         


Ala Gln Gln Ser Glu Pro Ile Ala Tyr Phe Arg Gly Leu Arg Leu Val 
        275                 280                 285             


Met Ser His Gly Pro Tyr Ile Lys Leu Ile Thr Gly Phe Leu Phe Thr 
    290                 295                 300                 


Ser Leu Ala Phe Met Leu Val Glu Gly Asn Phe Val Leu Phe Cys Thr 
305                 310                 315                 320 


Tyr Thr Leu Gly Phe Arg Asn Glu Phe Gln Asn Leu Leu Leu Ala Ile 
                325                 330                 335     


Met Leu Ser Ala Thr Leu Thr Ile Pro Ile Trp Gln Trp Phe Leu Thr 
            340                 345                 350         


Arg Phe Gly Lys Lys Thr Ala Val Tyr Val Gly Ile Ser Ser Ala Val 
        355                 360                 365             


Pro Phe Leu Ile Leu Val Ala Leu Met Glu Ser Asn Leu Ile Ile Thr 
    370                 375                 380                 


Tyr Ala Val Ala Val Ala Ala Gly Ile Ser Val Ala Ala Ala Phe Leu 
385                 390                 395                 400 


Leu Pro Trp Ser Met Leu Pro Asp Val Ile Asp Asp Phe His Leu Lys 
                405                 410                 415     


Gln Pro His Phe His Gly Thr Glu Pro Ile Phe Phe Ser Phe Tyr Val 
            420                 425                 430         


Phe Phe Thr Lys Phe Ala Ser Gly Val Ser Leu Gly Ile Ser Thr Leu 
        435                 440                 445             


Ser Leu Asp Phe Ala Gly Tyr Gln Thr Arg Gly Cys Ser Gln Pro Glu 
    450                 455                 460                 


Arg Val Lys Phe Thr Leu Asn Met Leu Val Thr Met Ala Pro Ile Val 
465                 470                 475                 480 


Leu Ile Leu Leu Gly Leu Leu Leu Phe Lys Met Tyr Pro Ile Asp Glu 
                485                 490                 495     


Glu Arg Arg Arg Gln Asn Lys Lys Ala Leu Gln Ala Leu Arg Asp Glu 
            500                 505                 510         


Ala Ser Ser Ser Gly Cys Ser Glu Thr Asp Ser Thr Glu Leu Ala Ser 
        515                 520                 525             


Ile Leu 
    530 


<210>  5403
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  5403

Met Gly Ser Gln Val Ser Val Glu Ser Gly Ala Leu His Val Val Ile 
1               5                   10                  15      


Val Gly Gly Gly Phe Gly Gly Ile Ala Ala Ala Ser Gln Leu Gln Ala 
            20                  25                  30          


Leu Asn Val Pro Phe Met Leu Val Asp Met Lys Asp Ser Phe His His 
        35                  40                  45              


Asn Val Ala Ala Leu Arg Ala Ser Val Glu Thr Gly Phe Ala Lys Lys 
    50                  55                  60                  


Thr Phe Ile Ser Tyr Ser Val Thr Phe Lys Asp Asn Phe Arg Gln Gly 
65                  70                  75                  80  


Leu Val Val Gly Ile Asp Leu Lys Asn Gln Met Val Leu Leu Gln Gly 
                85                  90                  95      


Gly Glu Ala Leu Pro Phe Ser His Leu Ile Leu Ala Thr Gly Ser Thr 
            100                 105                 110         


Gly Pro Phe Pro Gly Lys Phe Asn Glu Val Ser Ser Gln Gln Ala Ala 
        115                 120                 125             


Ile Gln Ala Tyr Glu Asp Met Val Arg Gln Val Gln Arg Ser Arg Phe 
    130                 135                 140                 


Ile Val Val Val Gly Gly Gly Ser Ala Gly Val Glu Met Ala Ala Glu 
145                 150                 155                 160 


Ile Lys Thr Glu Tyr Pro Glu Lys Glu Val Thr Leu Ile His Ser Gln 
                165                 170                 175     


Val Ala Leu Ala Asp Lys Glu Leu Leu Pro Ser Val Arg Gln Glu Val 
            180                 185                 190         


Lys Glu Ile Leu Leu Arg Lys Gly Val Gln Leu Leu Leu Ser Glu Arg 
        195                 200                 205             


Val Ser Asn Leu Glu Glu Leu Pro Leu Asn Glu Tyr Arg Glu Tyr Ile 
    210                 215                 220                 


Lys Val Gln Thr Asp Lys Gly Thr Glu Val Ala Thr Asn Leu Val Ile 
225                 230                 235                 240 


Leu Cys Thr Gly Ile Lys Ile Asn Ser Ser Ala Tyr Arg Lys Ala Phe 
                245                 250                 255     


Glu Ser Arg Leu Ala Ser Ser Gly Ala Leu Arg Val Asn Glu His Leu 
            260                 265                 270         


Gln Val Glu Gly His Ser Asn Val Tyr Ala Ile Gly Asp Cys Ala Asp 
        275                 280                 285             


Val Arg Thr Pro Lys Met Ala Tyr Leu Ala Gly Leu His Ala Asn Ile 
    290                 295                 300                 


Ala Val Ala Asn Ile Val Asn Ser Val Lys Gln Arg Pro Leu Gln Ala 
305                 310                 315                 320 


Tyr Lys Pro Gly Ala Leu Thr Phe Leu Leu Ser Met Gly Arg Asn Asp 
                325                 330                 335     


Gly Val Gly Gln Ile Ser Gly Phe Tyr Val Gly Arg Leu Met Val Arg 
            340                 345                 350         


Leu Thr Lys Ser Arg Asp Leu Phe Val Ser Thr Ser Trp Lys Thr Met 
        355                 360                 365             


Arg Gln Ser Pro Pro 
    370             


<210>  5404
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  5404

Met Ala Pro Trp Ala Leu Leu Ser Pro Gly Val Leu Val Arg Thr Gly 
1               5                   10                  15      


His Thr Val Leu Thr Trp Gly Ile Thr Leu Val Leu Phe Leu His Asp 
            20                  25                  30          


Thr Glu Leu Arg Gln Trp Glu Glu Gln Gly Glu Leu Leu Leu Pro Leu 
        35                  40                  45              


Thr Phe Leu Leu Leu Val Leu Gly Ser Leu Leu Leu Tyr Leu Ala Val 
    50                  55                  60                  


Ser Leu Met Asp Pro Gly Tyr Val Asn Val Gln Pro Gln Pro Gln Glu 
65                  70                  75                  80  


Glu Leu Lys Glu Glu Gln Thr Ala Met Val Pro Pro Ala Ile Pro Leu 
                85                  90                  95      


Arg Arg Cys Arg Tyr Cys Leu Val Leu Gln Pro Leu Arg Ala Arg His 
            100                 105                 110         


Cys Arg Glu Cys Arg Arg Cys Val Arg Arg Tyr Asp His His Cys Pro 
        115                 120                 125             


Trp Met Glu Asn Cys Val Gly Glu Arg Asn His Pro Leu Phe Val Val 
    130                 135                 140                 


Tyr Leu Ala Leu Gln Leu Val Val Leu Leu Trp Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Trp Ser Gly Leu Arg Phe Phe Gln Pro Trp Gly Leu Trp Leu Arg Ser 
                165                 170                 175     


Ser Gly Leu Leu Phe Ala Thr Phe Leu Leu Leu Ser Leu Phe Ser Leu 
            180                 185                 190         


Val Ala Ser Leu Leu Leu Val Ser His Leu Tyr Leu Val Ala Ser Asn 
        195                 200                 205             


Thr Thr Thr Trp Glu Phe Ile Ser Ser His Arg Ile Ala Tyr Leu Arg 
    210                 215                 220                 


Gln Arg Pro Ser Asn Pro Phe Asp Arg Gly Leu Thr Arg Asn Leu Ala 
225                 230                 235                 240 


His Phe Phe Cys Gly Trp Pro Ser Gly Ser Trp Glu Thr Leu Trp Ala 
                245                 250                 255     


Glu Glu Glu Glu Glu Gly Ser Ser Pro Ala Val 
            260                 265         


<210>  5405
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  5405

Met Gly Pro Gln Arg Arg Leu Ser Pro Ala Gly Ala Ala Leu Leu Trp 
1               5                   10                  15      


Gly Phe Leu Leu Gln Leu Thr Ala Ala Gln Glu Ala Ile Leu His Ala 
            20                  25                  30          


Ser Gly Asn Gly Thr Thr Lys Asp Tyr Cys Met Leu Tyr Asn Pro Tyr 
        35                  40                  45              


Trp Thr Ala Leu Pro Ser Thr Leu Glu Asn Ala Thr Ser Ile Ser Leu 
    50                  55                  60                  


Met Asn Leu Thr Ser Thr Pro Leu Cys Asn Leu Ser Asp Ile Pro Pro 
65                  70                  75                  80  


Val Gly Ile Lys Ser Lys Ala Val Val Val Pro Trp Gly Ser Cys His 
                85                  90                  95      


Phe Leu Glu Lys Ala Arg Ile Ala Gln Lys Gly Gly Ala Glu Ala Met 
            100                 105                 110         


Leu Val Val Asn Asn Ser Val Leu Phe Pro Pro Ser Gly Asn Arg Ser 
        115                 120                 125             


Glu Phe Pro Asp Val Lys Ile Leu Ile Ala Phe Ile Ser Tyr Lys Asp 
    130                 135                 140                 


Phe Arg Asp Met Asn Gln Thr Leu Gly Asp Asn Ile Thr Val Lys Met 
145                 150                 155                 160 


Tyr Ser Pro Ser Trp Pro Asn Phe Asp Tyr Thr Met Val Val Ile Phe 
                165                 170                 175     


Val Ile Ala Val Phe Thr Val Ala Leu Gly Gly Tyr Trp Ser Gly Leu 
            180                 185                 190         


Val Glu Leu Glu Asn Leu Lys Ala Val Thr Thr Glu Asp Arg Glu Met 
        195                 200                 205             


Arg Lys Lys Lys Glu Glu Tyr Leu Thr Phe Ser Pro Leu Thr Val Val 
    210                 215                 220                 


Ile Phe Val Val Ile Cys Cys Val Met Met Val Leu Leu Tyr Phe Phe 
225                 230                 235                 240 


Tyr Lys Trp Leu Val Tyr Val Met Ile Ala Ile Phe Cys Ile Ala Ser 
                245                 250                 255     


Ala Met Ser Leu Tyr Asn Cys Leu Ala Ala Leu Ile His Lys Ile Pro 
            260                 265                 270         


Tyr Gly Gln Cys Thr Ile Ala Cys Arg Gly Lys Asn Met Glu Val Arg 
        275                 280                 285             


Leu Ile Phe Leu Ser Gly Leu Cys Ile Ala Val Ala Val Val Trp Ala 
    290                 295                 300                 


Val Phe Arg Asn Glu Asp Arg Trp Ala Trp Ile Leu Gln Asp Ile Leu 
305                 310                 315                 320 


Gly Ile Ala Phe Cys Leu Asn Leu Ile Lys Thr Leu Lys Leu Pro Asn 
                325                 330                 335     


Phe Lys Ser Cys Val Ile Leu Leu Gly Leu Leu Leu Leu Tyr Asp Val 
            340                 345                 350         


Phe Phe Val Phe Ile Thr Pro Phe Ile Thr Lys Asn Gly Glu Ser Ile 
        355                 360                 365             


Met Val Glu Leu Ala Ala Gly Pro Phe Gly Asn Asn Glu Lys Leu Pro 
    370                 375                 380                 


Val Val Ile Arg Val Pro Lys Leu Ile Tyr Phe Ser Val Met Ser Val 
385                 390                 395                 400 


Cys Leu Met Pro Val Ser Ile Leu Gly Phe Gly Asp Ile Ile Val Pro 
                405                 410                 415     


Gly Leu Leu Ile Ala Tyr Cys Arg Arg Phe Asp Val Gln Thr Gly Ser 
            420                 425                 430         


Ser Tyr Ile Tyr Tyr Val Ser Ser Thr Val Ala Tyr Ala Ile Gly Met 
        435                 440                 445             


Ile Leu Thr Phe Val Val Leu Val Leu Met Lys Lys Gly Gln Pro Ala 
    450                 455                 460                 


Leu Leu Tyr Leu Val Pro Cys Thr Leu Ile Thr Ala Ser Val Val Ala 
465                 470                 475                 480 


Trp Arg Arg Lys Glu Met Lys Lys Phe Trp Lys Gly Asn Ser Tyr Gln 
                485                 490                 495     


Met Met Asp His Leu Asp Cys Ala Thr Asn Glu Glu Asn Pro Val Ile 
            500                 505                 510         


Ser Gly Glu Gln Ile Val Gln Gln 
        515                 520 


<210>  5406
<211>  620
<212>  PRT
<213>  Homo sapiens

<400>  5406

Met Gln Val Ser Lys Arg Met Leu Ala Gly Gly Val Arg Ser Met Pro 
1               5                   10                  15      


Ser Pro Leu Leu Ala Cys Trp Gln Pro Ile Leu Leu Leu Val Leu Gly 
            20                  25                  30          


Ser Val Leu Ser Gly Ser Ala Thr Gly Cys Pro Pro Arg Cys Glu Cys 
        35                  40                  45              


Ser Ala Gln Asp Arg Ala Val Leu Cys His Arg Lys Arg Phe Val Ala 
    50                  55                  60                  


Val Pro Glu Gly Ile Pro Thr Glu Thr Arg Leu Leu Asp Leu Gly Lys 
65                  70                  75                  80  


Asn Arg Ile Lys Thr Leu Asn Gln Asp Glu Phe Ala Ser Phe Pro His 
                85                  90                  95      


Leu Glu Glu Leu Glu Leu Asn Glu Asn Ile Val Ser Ala Val Glu Pro 
            100                 105                 110         


Gly Ala Phe Asn Asn Leu Phe Asn Leu Arg Thr Leu Gly Leu Arg Ser 
        115                 120                 125             


Asn Arg Leu Lys Leu Ile Pro Leu Gly Val Phe Thr Gly Leu Ser Asn 
    130                 135                 140                 


Leu Thr Lys Leu Asp Ile Ser Glu Asn Lys Ile Val Ile Leu Leu Asp 
145                 150                 155                 160 


Tyr Met Phe Gln Asp Leu Tyr Asn Leu Lys Ser Leu Glu Val Gly Asp 
                165                 170                 175     


Asn Asp Leu Val Tyr Ile Ser His Arg Ala Phe Ser Gly Leu Asn Ser 
            180                 185                 190         


Leu Glu Gln Leu Thr Leu Glu Lys Cys Asn Leu Thr Ser Ile Pro Thr 
        195                 200                 205             


Glu Ala Leu Ser His Leu His Gly Leu Ile Val Leu Arg Leu Arg His 
    210                 215                 220                 


Leu Asn Ile Asn Ala Ile Arg Asp Tyr Ser Phe Lys Arg Leu Tyr Arg 
225                 230                 235                 240 


Leu Lys Val Leu Glu Ile Ser His Trp Pro Tyr Leu Asp Thr Met Thr 
                245                 250                 255     


Pro Asn Cys Leu Tyr Gly Leu Asn Leu Thr Ser Leu Ser Ile Thr His 
            260                 265                 270         


Cys Asn Leu Thr Ala Val Pro Tyr Leu Ala Val Arg His Leu Val Tyr 
        275                 280                 285             


Leu Arg Phe Leu Asn Leu Ser Tyr Asn Pro Ile Ser Thr Ile Glu Gly 
    290                 295                 300                 


Ser Met Leu His Glu Leu Leu Arg Leu Gln Glu Ile Gln Leu Val Gly 
305                 310                 315                 320 


Gly Gln Leu Ala Val Val Glu Pro Tyr Ala Phe Arg Gly Leu Asn Tyr 
                325                 330                 335     


Leu Arg Val Leu Asn Val Ser Gly Asn Gln Leu Thr Thr Leu Glu Glu 
            340                 345                 350         


Ser Val Phe His Ser Val Gly Asn Leu Glu Thr Leu Ile Leu Asp Ser 
        355                 360                 365             


Asn Pro Leu Ala Cys Asp Cys Arg Leu Leu Trp Val Phe Arg Arg Arg 
    370                 375                 380                 


Trp Arg Leu Asn Phe Asn Arg Gln Gln Pro Thr Cys Ala Thr Pro Glu 
385                 390                 395                 400 


Phe Val Gln Gly Lys Glu Phe Lys Asp Phe Pro Asp Val Leu Leu Pro 
                405                 410                 415     


Asn Tyr Phe Thr Cys Arg Arg Ala Arg Ile Arg Asp Arg Lys Ala Gln 
            420                 425                 430         


Gln Val Phe Val Asp Glu Gly His Thr Val Gln Phe Val Cys Arg Ala 
        435                 440                 445             


Asp Gly Asp Pro Pro Pro Ala Ile Leu Trp Leu Ser Pro Arg Lys His 
    450                 455                 460                 


Leu Val Ser Ala Lys Ser Asn Gly Arg Leu Thr Val Phe Pro Asp Gly 
465                 470                 475                 480 


Thr Leu Glu Val Arg Tyr Ala Gln Val Gln Asp Asn Gly Thr Tyr Leu 
                485                 490                 495     


Cys Ile Ala Ala Asn Ala Gly Gly Asn Asp Ser Met Pro Ala His Leu 
            500                 505                 510         


His Val Arg Ser Tyr Ser Pro Asp Trp Pro His Gln Pro Asn Lys Thr 
        515                 520                 525             


Phe Ala Phe Ile Ser Asn Gln Pro Gly Glu Gly Glu Ala Asn Ser Thr 
    530                 535                 540                 


Arg Ala Thr Val Pro Phe Pro Phe Asp Ile Lys Thr Leu Ile Ile Ala 
545                 550                 555                 560 


Thr Thr Met Gly Phe Ile Ser Phe Leu Gly Val Val Leu Phe Cys Leu 
                565                 570                 575     


Val Leu Leu Phe Leu Trp Ser Arg Gly Lys Gly Asn Thr Lys His Asn 
            580                 585                 590         


Ile Glu Ile Glu Tyr Val Pro Arg Lys Ser Asp Ala Gly Ile Ser Ser 
        595                 600                 605             


Ala Asp Ala Pro Arg Lys Phe Asn Met Lys Met Ile 
    610                 615                 620 


<210>  5407
<211>  593
<212>  PRT
<213>  Homo sapiens

<400>  5407

Met Ala Phe Arg Arg Ala Glu Gly Thr Ser Met Ile Gln Ala Leu Ala 
1               5                   10                  15      


Met Thr Val Ala Glu Ile Pro Val Phe Leu Tyr Thr Thr Phe Gly Gln 
            20                  25                  30          


Ser Ala Phe Ser Gln Leu Arg Leu Thr Pro Gly Leu Arg Lys Val Leu 
        35                  40                  45              


Phe Ala Thr Ala Leu Gly Thr Val Ala Leu Ala Leu Ala Ala His Gln 
    50                  55                  60                  


Leu Lys Arg Arg Arg Arg Arg Lys Lys Gln Val Gly Pro Glu Met Gly 
65                  70                  75                  80  


Gly Glu Gln Leu Gly Thr Val Pro Leu Pro Ile Leu Leu Ala Arg Lys 
                85                  90                  95      


Val Pro Ser Val Lys Lys Gly Tyr Ser Ser Arg Arg Val Gln Ser Pro 
            100                 105                 110         


Ser Ser Lys Ser Asn Asp Thr Leu Ser Gly Ile Ser Ser Ile Glu Pro 
        115                 120                 125             


Ser Lys His Ser Gly Ser Ser His Ser Val Ala Ser Met Met Ala Val 
    130                 135                 140                 


Asn Ser Ser Ser Pro Thr Ala Ala Cys Ser Gly Leu Trp Asp Ala Arg 
145                 150                 155                 160 


Gly Met Glu Glu Ser Leu Thr Thr Ser Asp Gly Asn Ala Glu Ser Leu 
                165                 170                 175     


Tyr Met Gln Gly Met Glu Leu Phe Glu Glu Ala Leu Gln Lys Trp Glu 
            180                 185                 190         


Gln Ala Leu Ser Val Gly Gln Arg Gly Asp Ser Gly Ser Thr Pro Met 
        195                 200                 205             


Pro Arg Asp Gly Leu Arg Asn Pro Glu Thr Ala Ser Glu Pro Leu Ser 
    210                 215                 220                 


Glu Pro Glu Ser Gln Arg Lys Glu Phe Ala Glu Lys Leu Glu Ser Leu 
225                 230                 235                 240 


Leu His Arg Ala Tyr His Leu Gln Glu Glu Phe Gly Ser Thr Phe Pro 
                245                 250                 255     


Ala Asp Ser Met Leu Leu Asp Leu Glu Arg Thr Leu Met Leu Pro Leu 
            260                 265                 270         


Thr Glu Gly Ser Leu Arg Leu Arg Ala Asp Asp Glu Asp Ser Leu Thr 
        275                 280                 285             


Ser Glu Asp Ser Phe Phe Ser Ala Thr Glu Leu Phe Glu Ser Leu Gln 
    290                 295                 300                 


Thr Gly Asp Tyr Pro Ile Pro Leu Ser Arg Pro Ala Ala Ala Tyr Glu 
305                 310                 315                 320 


Glu Ala Leu Gln Leu Val Lys Glu Gly Arg Val Pro Cys Arg Thr Leu 
                325                 330                 335     


Arg Thr Glu Leu Leu Gly Cys Tyr Ser Asp Gln Asp Phe Leu Ala Lys 
            340                 345                 350         


Leu His Cys Val Arg Gln Ala Phe Glu Gly Leu Leu Glu Asp Lys Ser 
        355                 360                 365             


Asn Gln Leu Phe Phe Gly Lys Val Gly Arg Gln Met Val Thr Gly Leu 
    370                 375                 380                 


Met Thr Lys Ala Glu Lys Ser Pro Lys Gly Phe Leu Glu Ser Tyr Glu 
385                 390                 395                 400 


Glu Met Leu Ser Tyr Ala Leu Arg Pro Glu Thr Trp Ala Thr Thr Arg 
                405                 410                 415     


Leu Glu Leu Glu Gly Arg Gly Val Val Cys Met Ser Phe Phe Asp Ile 
            420                 425                 430         


Val Leu Asp Phe Ile Leu Met Asp Ala Phe Glu Asp Leu Glu Asn Pro 
        435                 440                 445             


Pro Ala Ser Val Leu Ala Val Leu Arg Asn Arg Trp Leu Ser Asp Ser 
    450                 455                 460                 


Phe Lys Glu Thr Ala Leu Ala Thr Ala Cys Trp Ser Val Leu Lys Ala 
465                 470                 475                 480 


Lys Arg Arg Leu Leu Met Val Pro Asp Gly Phe Ile Ser His Phe Tyr 
                485                 490                 495     


Ser Val Ser Glu His Val Ser Pro Val Leu Ala Phe Gly Phe Leu Gly 
            500                 505                 510         


Pro Lys Pro Gln Leu Ala Glu Val Cys Ala Phe Phe Lys His Gln Ile 
        515                 520                 525             


Val Gln Tyr Leu Arg Asp Met Phe Asp Leu Asp Asn Val Arg Tyr Thr 
    530                 535                 540                 


Ser Leu Pro Ala Leu Ala Asp Asp Ile Leu Gln Leu Ser Arg Arg Arg 
545                 550                 555                 560 


Ser Glu Ile Leu Leu Gly Tyr Leu Gly Val Pro Ala Ala Ser Ser Ala 
                565                 570                 575     


Gly Val Asn Gly Ala Leu Pro Arg Glu Asn Gly Pro Leu Gly Glu Leu 
            580                 585                 590         


Gln 
    


<210>  5408
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  5408

Met Ala Arg Phe Pro Lys Ala Asp Leu Ala Ala Ala Gly Val Met Leu 
1               5                   10                  15      


Leu Cys His Phe Phe Thr Asp Gln Phe Gln Phe Ala Asp Gly Lys Pro 
            20                  25                  30          


Gly Asp Gln Ile Leu Asp Trp Gln Tyr Gly Val Thr Gln Ala Phe Pro 
        35                  40                  45              


His Thr Glu Glu Glu Val Glu Val Asp Ser His Ala Tyr Ser His Arg 
    50                  55                  60                  


Trp Lys Arg Asn Leu Asp Phe Leu Lys Ala Val Asp Thr Asn Arg Ala 
65                  70                  75                  80  


Ser Val Gly Gln Asp Ser Pro Glu Pro Arg Ser Phe Thr Asp Leu Leu 
                85                  90                  95      


Leu Asp Asp Gly Gln Asp Asn Asn Thr Gln Ile Glu Glu Asp Thr Asp 
            100                 105                 110         


His Asn Tyr Tyr Ile Ser Arg Ile Tyr Gly Pro Ser Asp Ser Ala Ser 
        115                 120                 125             


Arg Asp Leu Trp Val Asn Ile Asp Gln Met Glu Lys Asp Lys Val Lys 
    130                 135                 140                 


Ile His Gly Ile Leu Ser Asn Thr His Arg Gln Ala Ala Arg Val Asn 
145                 150                 155                 160 


Leu Ser Phe Asp Phe Pro Phe Tyr Gly His Phe Leu Arg Glu Ile Thr 
                165                 170                 175     


Val Ala Thr Gly Gly Phe Ile Tyr Thr Gly Glu Val Val His Arg Met 
            180                 185                 190         


Leu Thr Ala Thr Gln Tyr Ile Ala Pro Leu Met Ala Asn Phe Asp Pro 
        195                 200                 205             


Ser Val Ser Arg Asn Ser Thr Val Arg Tyr Phe Asp Asn Gly Thr Ala 
    210                 215                 220                 


Leu Val Val Gln Trp Asp His Val His Leu Gln Asp Asn Tyr Asn Leu 
225                 230                 235                 240 


Gly Ser Phe Thr Phe Gln Ala Thr Leu Leu Met Asp Gly Arg Ile Ile 
                245                 250                 255     


Phe Gly Tyr Lys Glu Ile Pro Val Leu Val Thr Gln Ile Ser Ser Thr 
            260                 265                 270         


Asn His Pro Val Lys Val Gly Leu Ser Asp Ala Phe Val Val Val His 
        275                 280                 285             


Arg Ile Gln Gln Ile Pro Asn Val Arg Arg Arg Thr Ile Tyr Glu Tyr 
    290                 295                 300                 


His Arg Val Glu Leu Gln Met Ser Lys Ile Thr Asn Ile Ser Ala Val 
305                 310                 315                 320 


Glu Met Thr Pro Leu Pro Thr Cys Leu Gln Phe Asn Arg Cys Gly Pro 
                325                 330                 335     


Cys Val Ser Ser Gln Ile Gly Phe Asn Cys Ser Trp Cys Ser Lys Leu 
            340                 345                 350         


Gln Arg Cys Ser Ser Gly Phe Asp Arg His Arg Gln Asp Trp Val Asp 
        355                 360                 365             


Ser Gly Cys Pro Glu Glu Ser Lys Glu Lys Met Cys Glu Asn Thr Glu 
    370                 375                 380                 


Pro Val Glu Thr Ser Ser Arg Thr Thr Thr Thr Val Gly Ala Thr Thr 
385                 390                 395                 400 


Thr Gln Phe Arg Val Leu Thr Thr Thr Arg Arg Ala Val Thr Ser Gln 
                405                 410                 415     


Phe Pro Thr Ser Leu Pro Thr Glu Asp Asp Thr Lys Ile Ala Leu His 
            420                 425                 430         


Leu Lys Asp Asn Gly Ala Ser Thr Asp Asp Ser Ala Ala Glu Lys Lys 
        435                 440                 445             


Gly Gly Thr Leu His Ala Gly Leu Ile Ile Gly Ile Leu Ile Leu Val 
    450                 455                 460                 


Leu Ile Val Ala Thr Ala Ile Leu Val Thr Val Tyr Met Tyr His His 
465                 470                 475                 480 


Pro Thr Ser Ala Ala Ser Ile Phe Phe Ile Glu Arg Arg Pro Ser Arg 
                485                 490                 495     


Trp Pro Ala Met Lys Phe Arg Arg Gly Ser Gly His Pro Ala Tyr Ala 
            500                 505                 510         


Glu Val Glu Pro Val Gly Glu Lys Glu Gly Phe Ile Val Ser Glu Gln 
        515                 520                 525             


Cys 
    


<210>  5409
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  5409

Met Ile Pro Asn Gln His Asn Ala Gly Ala Gly Ser His Gln Pro Ala 
1               5                   10                  15      


Val Phe Arg Met Ala Val Leu Asp Thr Asp Leu Asp His Ile Leu Pro 
            20                  25                  30          


Ser Ser Val Leu Pro Pro Phe Trp Ala Lys Leu Val Val Gly Ser Val 
        35                  40                  45              


Ala Ile Val Cys Phe Ala Arg Ser Tyr Asp Gly Asp Phe Val Phe Asp 
    50                  55                  60                  


Asp Ser Glu Ala Ile Val Asn Asn Lys Asp Leu Gln Ala Glu Thr Pro 
65                  70                  75                  80  


Leu Gly Asp Leu Trp His His Asp Phe Trp Gly Ser Arg Leu Ser Ser 
                85                  90                  95      


Asn Thr Ser His Lys Ser Tyr Arg Pro Leu Thr Val Leu Thr Phe Arg 
            100                 105                 110         


Ile Asn Tyr Tyr Leu Ser Gly Gly Phe His Pro Val Gly Phe His Val 
        115                 120                 125             


Val Asn Ile Leu Leu His Ser Gly Ile Ser Val Leu Met Val Asp Val 
    130                 135                 140                 


Phe Ser Val Leu Phe Gly Gly Leu Gln Tyr Thr Ser Lys Gly Arg Arg 
145                 150                 155                 160 


Leu His Leu Ala Pro Arg Ala Ser Leu Leu Ala Ala Leu Leu Phe Ala 
                165                 170                 175     


Val His Pro Val His Thr Glu Cys Val Ala Gly Val Val Gly Arg Ala 
            180                 185                 190         


Asp Leu Leu Cys Ala Leu Phe Phe Leu Leu Ser Phe Leu Gly Tyr Cys 
        195                 200                 205             


Lys Ala Phe Arg Glu Ser Asn Lys Glu Gly Ala His Ser Ser Thr Phe 
    210                 215                 220                 


Trp Val Leu Leu Ser Ile Phe Leu Gly Ala Val Ala Met Leu Cys Lys 
225                 230                 235                 240 


Glu Gln Gly Ile Thr Val Leu Gly Leu Asn Ala Val Phe Asp Ile Leu 
                245                 250                 255     


Val Ile Gly Lys Phe Asn Val Leu Glu Ile Val Gln Lys Val Leu His 
            260                 265                 270         


Lys Asp Lys Ser Leu Glu Asn Leu Gly Met Leu Arg Asn Gly Gly Leu 
        275                 280                 285             


Leu Phe Arg Met Thr Leu Leu Thr Ser Gly Gly Ala Gly Met Leu Tyr 
    290                 295                 300                 


Val Arg Trp Arg Ile Met Gly Thr Gly Pro Pro Ala Phe Thr Glu Val 
305                 310                 315                 320 


Asp Asn Pro Ala Ser Phe Ala Asp Ser Met Leu Val Arg Ala Val Asn 
                325                 330                 335     


Tyr Asn Tyr Tyr Tyr Ser Leu Asn Ala Trp Leu Leu Leu Cys Pro Trp 
            340                 345                 350         


Trp Leu Cys Phe Asp Trp Ser Met Gly Cys Ile Pro Leu Ile Lys Ser 
        355                 360                 365             


Ile Ser Asp Trp Arg Val Ile Ala Leu Ala Ala Leu Trp Phe Cys Leu 
    370                 375                 380                 


Ile Gly Leu Ile Cys Gln Ala Leu Cys Ser Glu Asp Gly His Lys Arg 
385                 390                 395                 400 


Arg Ile Leu Thr Leu Gly Leu Gly Phe Leu Val Ile Pro Phe Leu Pro 
                405                 410                 415     


Ala Ser Asn Leu Phe Phe Arg Val Gly Phe Val Val Ala Glu Arg Val 
            420                 425                 430         


Leu Tyr Leu Pro Ser Val Gly Tyr Cys Val Leu Leu Thr Phe Gly Phe 
        435                 440                 445             


Gly Ala Leu Ser Lys His Thr Lys Lys Lys Lys Leu Ile Ala Ala Val 
    450                 455                 460                 


Val Leu Gly Ile Leu Phe Ile Asn Thr Leu Arg Cys Val Leu Arg Ser 
465                 470                 475                 480 


Gly Glu Trp Arg Ser Glu Glu Gln Leu Phe Arg Ser Ala Leu Ser Val 
                485                 490                 495     


Cys Pro Leu Asn Ala Lys Val His Tyr Asn Ile Gly Lys Asn Leu Ala 
            500                 505                 510         


Asp Lys Gly Asn Gln Thr Ala Ala Ile Arg Tyr Tyr Arg Glu Ala Val 
        515                 520                 525             


Arg Leu Asn Pro Lys Tyr Val His Ala Met Asn Asn Leu Gly Asn Ile 
    530                 535                 540                 


Leu Lys Glu Arg Asn Glu Leu Gln Glu Ala Glu Glu Leu Leu Ser Leu 
545                 550                 555                 560 


Ala Val Gln Ile Gln Pro Asp Phe Ala Ala Ala Trp Met Asn Leu Gly 
                565                 570                 575     


Ile Val Gln Asn Ser Leu Lys Arg Phe Glu Ala Ala Glu Gln Ser Tyr 
            580                 585                 590         


Arg Thr Ala Ile Lys His Arg Arg Lys Tyr Pro Asp Cys Tyr Tyr Asn 
        595                 600                 605             


Leu Gly Arg Leu Tyr Ala Asp Leu Asn Arg His Val Asp Ala Leu Asn 
    610                 615                 620                 


Ala Trp Arg Asn Ala Thr Val Leu Lys Pro Glu His Ser Leu Ala Trp 
625                 630                 635                 640 


Asn Asn Met Ile Ile Leu Leu Asp Asn Thr Gly Asn Leu Ala Gln Ala 
                645                 650                 655     


Glu Ala Val Gly Arg Glu Ala Leu Glu Leu Ile Pro Asn Asp His Ser 
            660                 665                 670         


Leu Met Phe Ser Leu Ala Asn Val Leu Gly Lys Ser Gln Lys Tyr Lys 
        675                 680                 685             


Glu Ser Glu Ala Leu Phe Leu Lys Ala Ile Lys Ala Asn Pro Asn Ala 
    690                 695                 700                 


Ala Ser Tyr His Gly Asn Leu Ala Val Leu Tyr His Arg Trp Gly His 
705                 710                 715                 720 


Leu Asp Leu Ala Lys Lys His Tyr Glu Ile Ser Leu Gln Leu Asp Pro 
                725                 730                 735     


Thr Ala Ser Gly Thr Lys Glu Asn Tyr Gly Leu Leu Arg Arg Lys Leu 
            740                 745                 750         


Glu Leu Met Gln Lys Lys Ala Val 
        755                 760 


<210>  5410
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  5410

Met Val Ala Ala Cys Arg Ser Val Ala Gly Leu Leu Pro Arg Arg Arg 
1               5                   10                  15      


Arg Cys Phe Pro Ala Arg Ala Pro Leu Leu Arg Val Ala Leu Cys Leu 
            20                  25                  30          


Leu Cys Trp Thr Pro Ala Ala Val Arg Ala Val Pro Glu Leu Gly Leu 
        35                  40                  45              


Trp Leu Glu Thr Val Asn Asp Lys Ser Gly Pro Leu Ile Phe Arg Lys 
    50                  55                  60                  


Thr Met Phe Asn Ser Thr Asp Ile Lys Leu Ser Val Lys Ser Phe His 
65                  70                  75                  80  


Cys Ser Gly Pro Val Lys Phe Thr Ile Val Trp His Leu Lys Tyr His 
                85                  90                  95      


Thr Cys His Asn Glu His Ser Asn Leu Glu Glu Leu Phe Gln Lys His 
            100                 105                 110         


Lys Leu Ser Val Asp Glu Asp Phe Cys His Tyr Leu Lys Asn Asp Asn 
        115                 120                 125             


Cys Trp Thr Thr Lys Asn Glu Asn Leu Asp Cys Asn Ser Asp Ser Gln 
    130                 135                 140                 


Val Phe Pro Ser Leu Asn Asn Lys Glu Leu Ile Asn Ile Arg Asn Val 
145                 150                 155                 160 


Ser Asn Gln Glu Arg Ser Met Asp Val Val Ala Arg Thr Gln Lys Asp 
                165                 170                 175     


Gly Phe His Ile Phe Ile Val Ser Ile Lys Thr Glu Asn Thr Asp Ala 
            180                 185                 190         


Ser Trp Asn Leu Asn Val Ser Leu Ser Met Ile Gly Pro His Gly Tyr 
        195                 200                 205             


Ile Ser Ala Ser Asp Trp Pro Leu Met Ile Phe Tyr Met Val Met Cys 
    210                 215                 220                 


Ile Val Tyr Ile Leu Tyr Gly Ile Leu Trp Leu Thr Trp Ser Ala Cys 
225                 230                 235                 240 


Tyr Trp Lys Asp Ile Leu Arg Ile Gln Phe Trp Ile Ala Ala Val Ile 
                245                 250                 255     


Phe Leu Gly Met Leu Glu Lys Ala Val Phe Tyr Ser Glu Tyr Gln Asn 
            260                 265                 270         


Ile Ser Asn Thr Gly Leu Ser Thr Gln Gly Leu Leu Ile Phe Ala Glu 
        275                 280                 285             


Leu Ile Ser Ala Ile Lys Arg Thr Leu Ala Arg Leu Leu Val Ile Ile 
    290                 295                 300                 


Val Ser Leu Gly Tyr Gly Ile Val Lys Pro Arg Leu Gly Thr Val Met 
305                 310                 315                 320 


His Arg Val Ile Gly Leu Gly Leu Leu Tyr Leu Ile Phe Ala Ala Val 
                325                 330                 335     


Glu Gly Val Met Arg Val Ile Gly Gly Ser Asn His Leu Ala Val Val 
            340                 345                 350         


Leu Asp Asp Ile Ile Leu Ala Val Ile Asp Ser Ile Phe Val Trp Phe 
        355                 360                 365             


Ile Phe Ile Ser Leu Ala Gln Thr Met Lys Thr Leu Arg Leu Arg Lys 
    370                 375                 380                 


Asn Thr Val Lys Phe Ser Leu Tyr Arg His Phe Lys Asn Thr Leu Ile 
385                 390                 395                 400 


Phe Ala Val Leu Ala Ser Ile Val Phe Met Gly Trp Thr Thr Lys Thr 
                405                 410                 415     


Phe Arg Ile Ala Lys Cys Gln Ser Asp Trp Met Glu Arg Trp Val Asp 
            420                 425                 430         


Asp Ala Phe Trp Ser Phe Leu Phe Ser Leu Ile Leu Ile Val Ile Met 
        435                 440                 445             


Phe Leu Trp Arg Pro Ser Ala Asn Asn Gln Arg Tyr Ala Phe Met Pro 
    450                 455                 460                 


Leu Ile Asp Asp Ser Asp Asp Glu Ile Glu Glu Phe Met Val Thr Ser 
465                 470                 475                 480 


Glu Asn Leu Thr Glu Gly Ile Lys Leu Arg Ala Ser Lys Ser Val Ser 
                485                 490                 495     


Asn Gly Thr Ala Lys Pro Ala Thr Ser Glu Asn Phe Asp Glu Asp Leu 
            500                 505                 510         


Lys Trp Val Glu Glu Asn Ile Pro Ser Ser Phe Thr Asp Val Ala Leu 
        515                 520                 525             


Pro Val Leu Val Asp Ser Asp Glu Glu Ile Met Thr Arg Ser Glu Met 
    530                 535                 540                 


Ala Glu Lys Met Phe Ser Ser Glu Lys Ile Met 
545                 550                 555 


<210>  5411
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  5411

Met Arg Pro Ala Leu Ala Val Gly Leu Val Phe Ala Gly Cys Cys Ser 
1               5                   10                  15      


Asn Val Ile Phe Leu Glu Leu Leu Ala Arg Lys His Pro Gly Cys Gly 
            20                  25                  30          


Asn Ile Val Thr Phe Ala Gln Phe Leu Phe Ile Ala Val Glu Gly Phe 
        35                  40                  45              


Leu Phe Glu Ala Asp Leu Gly Arg Lys Pro Pro Ala Ile Pro Ile Arg 
    50                  55                  60                  


Tyr Tyr Ala Ile Met Val Thr Met Phe Phe Thr Val Ser Val Val Asn 
65                  70                  75                  80  


Asn Tyr Ala Leu Asn Leu Asn Ile Ala Met Pro Leu His Met Ile Phe 
                85                  90                  95      


Arg Ser Gly Ser Leu Ile Ala Asn Met Ile Leu Gly Ile Ile Ile Leu 
            100                 105                 110         


Lys Lys Arg Tyr Ser Ile Phe Lys Tyr Thr Ser Ile Ala Leu Val Ser 
        115                 120                 125             


Val Gly Ile Phe Ile Cys Thr Phe Met Ser Ala Lys Gln Val Thr Ser 
    130                 135                 140                 


Gln Ser Ser Leu Ser Glu Asn Asp Gly Phe Gln Ala Phe Val Trp Trp 
145                 150                 155                 160 


Leu Leu Gly Ile Gly Ala Leu Thr Phe Ala Leu Leu Met Ser Ala Arg 
                165                 170                 175     


Met Gly Ile Phe Gln Glu Thr Leu Tyr Lys Arg Phe Gly Lys His Ser 
            180                 185                 190         


Lys Glu Ala Leu Phe Tyr Asn His Ala Leu Pro Leu Pro Gly Phe Val 
        195                 200                 205             


Phe Leu Ala Ser Asp Ile Tyr Asp His Ala Val Leu Phe Asn Lys Ser 
    210                 215                 220                 


Glu Leu Tyr Glu Ile Pro Val Ile Gly Val Thr Leu Pro Ile Met Trp 
225                 230                 235                 240 


Phe Tyr Leu Leu Met Asn Ile Ile Thr Gln Tyr Val Cys Ile Arg Gly 
                245                 250                 255     


Val Phe Ile Leu Thr Thr Glu Cys Ala Ser Leu Thr Val Thr Leu Val 
            260                 265                 270         


Val Thr Leu Arg Lys Phe Val Ser Leu Ile Phe Ser Ile Leu Tyr Phe 
        275                 280                 285             


Gln Asn Pro Phe Thr Leu Trp His Trp Leu Gly Thr Leu Phe Val Phe 
    290                 295                 300                 


Ile Gly Thr Leu Met Tyr Thr Glu Val Trp Asn Asn Leu Gly Thr Thr 
305                 310                 315                 320 


Lys Ser Glu Pro Gln Lys Asp Ser Lys Lys Asn 
                325                 330     


<210>  5412
<211>  686
<212>  PRT
<213>  Homo sapiens

<400>  5412

Met Gly Glu Phe Lys Val His Arg Val Arg Phe Phe Asn Tyr Val Pro 
1               5                   10                  15      


Ser Gly Ile Arg Cys Val Ala Tyr Asn Asn Gln Ser Asn Arg Leu Ala 
            20                  25                  30          


Val Ser Arg Thr Asp Gly Thr Val Glu Ile Tyr Asn Leu Ser Ala Asn 
        35                  40                  45              


Tyr Phe Gln Glu Lys Phe Phe Pro Gly His Glu Ser Arg Ala Thr Glu 
    50                  55                  60                  


Ala Leu Cys Trp Ala Glu Gly Gln Arg Leu Phe Ser Ala Gly Leu Asn 
65                  70                  75                  80  


Gly Glu Ile Met Glu Tyr Asp Leu Gln Ala Leu Asn Ile Lys Tyr Ala 
                85                  90                  95      


Met Asp Ala Phe Gly Gly Pro Ile Trp Ser Met Ala Ala Ser Pro Ser 
            100                 105                 110         


Gly Ser Gln Leu Leu Val Gly Cys Glu Asp Gly Ser Val Lys Leu Phe 
        115                 120                 125             


Gln Ile Thr Pro Asp Lys Ile Gln Phe Glu Arg Asn Phe Asp Arg Gln 
    130                 135                 140                 


Lys Ser Arg Ile Leu Ser Leu Ser Trp His Pro Ser Gly Thr His Ile 
145                 150                 155                 160 


Ala Ala Gly Ser Ile Asp Tyr Ile Ser Val Phe Asp Val Lys Ser Gly 
                165                 170                 175     


Ser Ala Val His Lys Met Ile Val Asp Arg Gln Tyr Met Gly Val Ser 
            180                 185                 190         


Lys Arg Lys Cys Ile Val Trp Gly Val Ala Phe Leu Ser Asp Gly Thr 
        195                 200                 205             


Ile Ile Ser Val Asp Ser Ala Gly Lys Val Gln Phe Trp Asp Ser Ala 
    210                 215                 220                 


Thr Gly Thr Leu Val Lys Ser His Leu Ile Ala Asn Ala Asp Val Gln 
225                 230                 235                 240 


Ser Ile Ala Val Ala Asp Gln Glu Asp Ser Phe Val Val Gly Thr Ala 
                245                 250                 255     


Glu Gly Thr Val Phe His Phe Gln Leu Val Pro Val Thr Ser Asn Ser 
            260                 265                 270         


Ser Glu Lys Gln Trp Val Arg Thr Lys Pro Phe Gln His His Thr His 
        275                 280                 285             


Asp Val Arg Thr Val Ala His Ser Pro Thr Ala Leu Ile Ser Gly Gly 
    290                 295                 300                 


Thr Asp Thr His Leu Val Phe Arg Pro Leu Met Glu Lys Val Glu Val 
305                 310                 315                 320 


Lys Asn Tyr Asp Ala Ala Leu Arg Lys Ile Thr Phe Pro His Arg Cys 
                325                 330                 335     


Leu Ile Ser Cys Ser Lys Lys Arg Gln Leu Leu Leu Phe Gln Phe Ala 
            340                 345                 350         


His His Leu Glu Leu Trp Arg Leu Gly Ser Thr Val Ala Thr Gly Lys 
        355                 360                 365             


Asn Gly Asp Thr Leu Pro Leu Ser Lys Asn Ala Asp His Leu Leu His 
    370                 375                 380                 


Leu Lys Thr Lys Gly Pro Glu Asn Ile Ile Cys Ser Cys Ile Ser Pro 
385                 390                 395                 400 


Cys Gly Ser Trp Ile Ala Tyr Ser Thr Val Ser Arg Phe Phe Leu Tyr 
                405                 410                 415     


Arg Leu Asn Tyr Glu His Asp Asn Ile Ser Leu Lys Arg Val Ser Lys 
            420                 425                 430         


Met Pro Ala Phe Leu Arg Ser Ala Leu Gln Ile Leu Phe Ser Glu Asp 
        435                 440                 445             


Ser Thr Lys Leu Phe Val Ala Ser Asn Gln Gly Ala Leu His Ile Val 
    450                 455                 460                 


Gln Leu Ser Gly Gly Ser Phe Lys His Leu His Ala Phe Gln Pro Gln 
465                 470                 475                 480 


Ser Gly Thr Val Glu Ala Met Cys Leu Leu Ala Val Ser Pro Asp Gly 
                485                 490                 495     


Asn Trp Leu Ala Ala Ser Gly Thr Ser Ala Gly Val His Val Tyr Asn 
            500                 505                 510         


Val Lys Gln Leu Lys Leu His Cys Thr Val Pro Ala Tyr Asn Phe Pro 
        515                 520                 525             


Val Thr Ala Met Ala Ile Ala Pro Asn Thr Asn Asn Leu Val Ile Ala 
    530                 535                 540                 


His Ser Asp Gln Gln Val Phe Glu Tyr Ser Ile Pro Asp Lys Gln Tyr 
545                 550                 555                 560 


Thr Asp Trp Ser Arg Thr Val Gln Lys Gln Gly Phe His His Leu Trp 
                565                 570                 575     


Leu Gln Arg Asp Thr Pro Ile Thr His Ile Ser Phe His Pro Lys Arg 
            580                 585                 590         


Pro Met His Ile Leu Leu His Asp Ala Tyr Met Phe Cys Ile Ile Asp 
        595                 600                 605             


Lys Ser Leu Pro Leu Pro Asn Asp Lys Thr Leu Leu Tyr Asn Pro Phe 
    610                 615                 620                 


Pro Pro Thr Asn Glu Ser Asp Val Ile Arg Arg Arg Thr Ala His Ala 
625                 630                 635                 640 


Phe Lys Ile Ser Lys Ile Tyr Lys Pro Leu Leu Phe Met Asp Leu Leu 
                645                 650                 655     


Asp Glu Arg Thr Leu Val Ala Val Glu Arg Pro Leu Asp Asp Ile Ile 
            660                 665                 670         


Ala Gln Leu Pro Pro Pro Ile Lys Lys Lys Lys Phe Gly Thr 
        675                 680                 685     


<210>  5413
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  5413

Met Ser Ala Glu Leu Asn Val Pro Ile Asp Pro Ser Ala Pro Ala Cys 
1               5                   10                  15      


Pro Glu Pro Gly His Lys Gly Met Asp Tyr Arg Asp Trp Val Arg Arg 
            20                  25                  30          


Ser Tyr Leu Glu Leu Val Thr Ser Asn His His Ser Val Gln Ala Leu 
        35                  40                  45              


Ser Trp Arg Lys Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser 
    50                  55                  60                  


Arg Thr Ser Ala Leu Leu Ser Gly Phe Ala Met Val Ala Met Val Glu 
65                  70                  75                  80  


Val Gln Leu Glu Thr Gln Tyr Gln Tyr Pro Arg Pro Leu Leu Ile Ala 
                85                  90                  95      


Phe Ser Ala Cys Thr Thr Val Leu Val Ala Val His Leu Phe Ala Leu 
            100                 105                 110         


Leu Ile Ser Thr Cys Ile Leu Pro Asn Val Glu Ala Val Ser Asn Ile 
        115                 120                 125             


His Asn Leu Asn Ser Ile Ser Glu Ser Pro His Glu Arg Met His Pro 
    130                 135                 140                 


Tyr Ile Glu Leu Ala Trp Gly Phe Ser Thr Val Leu Gly Ile Leu Leu 
145                 150                 155                 160 


Phe Leu Ala Glu Val Val Leu Leu Cys Trp Ile Lys Phe Leu Pro Val 
                165                 170                 175     


Asp Ala Arg Arg Gln Pro Gly Pro Pro Pro Gly Pro Gly Ser His Thr 
            180                 185                 190         


Gly Trp Gln Ala Ala Leu Val Ser Thr Ile Ile Met Val Pro Val Gly 
        195                 200                 205             


Leu Ile Phe Val Val Phe Thr Ile His Phe Tyr Arg Ser Leu Val Arg 
    210                 215                 220                 


His Lys Thr Glu Arg His Asn Arg Glu Ile Glu Glu Leu His Lys Leu 
225                 230                 235                 240 


Lys Val Gln Leu Asp Gly His Glu Arg Ser Leu Gln Val Leu 
                245                 250                 


<210>  5414
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  5414

Met Ala Ser Val Ala Gln Glu Ser Ala Gly Ser Gln Arg Arg Leu Pro 
1               5                   10                  15      


Pro Arg His Gly Ala Leu Arg Gly Leu Leu Leu Leu Cys Leu Trp Leu 
            20                  25                  30          


Pro Ser Gly Arg Ala Ala Leu Pro Pro Ala Ala Pro Leu Ser Glu Leu 
        35                  40                  45              


His Ala Gln Leu Ser Gly Val Glu Gln Leu Leu Glu Glu Phe Arg Arg 
    50                  55                  60                  


Gln Leu Gln Gln Glu Arg Pro Gln Glu Glu Leu Glu Leu Glu Leu Arg 
65                  70                  75                  80  


Ala Gly Gly Gly Pro Gln Glu Asp Cys Pro Gly Pro Gly Ser Gly Gly 
                85                  90                  95      


Tyr Ser Ala Met Pro Asp Ala Ile Ile Arg Thr Lys Asp Ser Leu Ala 
            100                 105                 110         


Ala Gly Ala Ser Phe Leu Arg Ala Pro Ala Ala Val Arg Gly Trp Arg 
        115                 120                 125             


Gln Cys Val Ala Ala Cys Cys Ser Glu Pro Arg Cys Ser Val Ala Val 
    130                 135                 140                 


Val Glu Leu Pro Arg Arg Pro Ala Pro Pro Ala Ala Val Leu Gly Cys 
145                 150                 155                 160 


Tyr Leu Phe Asn Cys Thr Ala Arg Gly Arg Asn Val Cys Lys Phe Ala 
                165                 170                 175     


Leu His Ser Gly Tyr Ser Ser Tyr Ser Leu Ser Arg Ala Pro Asp Gly 
            180                 185                 190         


Ala Ala Leu Ala Thr Ala Arg Ala Ser Pro Arg Gln Glu Lys Asp Ala 
        195                 200                 205             


Pro Pro Leu Ser Lys Ala Gly Gln Asp Val Val Leu His Leu Pro Thr 
    210                 215                 220                 


Asp Gly Val Val Leu Asp Gly Arg Glu Ser Thr Asp Asp His Ala Ile 
225                 230                 235                 240 


Val Gln Tyr Glu Trp Ala Leu Leu Gln Gly Asp Pro Ser Val Asp Met 
                245                 250                 255     


Lys Val Pro Gln Ser Gly Thr Leu Lys Leu Ser His Leu Gln Glu Gly 
            260                 265                 270         


Thr Tyr Thr Phe Gln Leu Thr Val Thr Asp Thr Ala Gly Gln Arg Ser 
        275                 280                 285             


Ser Asp Asn Val Ser Val Thr Val Leu Arg Ala Ala Tyr Ser Thr Gly 
    290                 295                 300                 


Gly Cys Leu His Thr Cys Ser Arg Tyr His Phe Phe Cys Asp Asp Gly 
305                 310                 315                 320 


Cys Cys Ile Asp Ile Thr Leu Ala Cys Asp Gly Val Gln Gln Cys Pro 
                325                 330                 335     


Asp Gly Ser Asp Glu Asp Phe Cys Gln Asn Leu Gly Leu Asp Arg Lys 
            340                 345                 350         


Met Val Thr His Thr Ala Ala Ser Pro Ala Leu Pro Arg Thr Thr Gly 
        355                 360                 365             


Pro Ser Glu Asp Ala Gly Gly Asp Ser Leu Val Glu Lys Ser Gln Lys 
    370                 375                 380                 


Ala Thr Ala Pro Asn Lys Pro Pro Ala Leu Ser Asn Thr Glu Lys Arg 
385                 390                 395                 400 


Asn His Ser Ala Phe Trp Gly Pro Glu Ser Gln Ile Ile Pro Val Met 
                405                 410                 415     


Pro Asp Ser Ser Ser Ser Gly Lys Asn Arg Lys Glu Glu Ser Tyr Ile 
            420                 425                 430         


Phe Glu Ser Lys Gly Asp Gly Gly Gly Gly Glu His Pro Ala Pro Glu 
        435                 440                 445             


Thr Gly Ala Val Leu Pro Leu Ala Leu Gly Leu Ala Ile Thr Ala Leu 
    450                 455                 460                 


Leu Leu Leu Met Val Ala Cys Arg Leu Arg Leu Val Lys Gln Lys Leu 
465                 470                 475                 480 


Lys Lys Ala Arg Pro Ile Thr Ser Glu Glu Ser Asp Tyr Leu Ile Asn 
                485                 490                 495     


Gly Met Tyr Leu 
            500 


<210>  5415
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  5415

Met Ala Gln Leu Glu Gly Tyr Tyr Phe Ser Ala Ala Leu Ser Cys Thr 
1               5                   10                  15      


Phe Leu Val Ser Cys Leu Leu Phe Ser Ala Phe Ser Arg Ala Leu Arg 
            20                  25                  30          


Glu Pro Tyr Met Asp Glu Ile Phe His Leu Pro Gln Ala Gln Arg Tyr 
        35                  40                  45              


Cys Glu Gly His Phe Ser Leu Ser Gln Trp Asp Pro Met Ile Thr Thr 
    50                  55                  60                  


Leu Pro Gly Leu Tyr Leu Val Ser Ile Gly Val Ile Lys Pro Ala Ile 
65                  70                  75                  80  


Trp Ile Phe Gly Trp Ser Glu His Val Val Cys Ser Ile Gly Met Leu 
                85                  90                  95      


Arg Phe Val Asn Leu Leu Phe Ser Val Gly Asn Phe Tyr Leu Leu Tyr 
            100                 105                 110         


Leu Leu Phe Cys Lys Val Gln Pro Arg Asn Lys Ala Ala Ser Ser Ile 
        115                 120                 125             


Gln Arg Val Leu Ser Thr Leu Thr Leu Ala Val Phe Pro Thr Leu Tyr 
    130                 135                 140                 


Phe Phe Asn Phe Leu Tyr Tyr Thr Glu Ala Gly Ser Met Phe Phe Thr 
145                 150                 155                 160 


Leu Phe Ala Tyr Leu Met Cys Leu Tyr Gly Asn His Lys Thr Ser Ala 
                165                 170                 175     


Phe Leu Gly Phe Cys Gly Phe Met Phe Arg Gln Thr Asn Ile Ile Trp 
            180                 185                 190         


Ala Val Phe Cys Ala Gly Asn Val Ile Ala Gln Lys Leu Thr Glu Ala 
        195                 200                 205             


Trp Lys Thr Glu Leu Gln Lys Lys Glu Asp Arg Leu Pro Pro Ile Lys 
    210                 215                 220                 


Gly Pro Phe Ala Glu Phe Arg Lys Ile Leu Gln Phe Leu Leu Ala Tyr 
225                 230                 235                 240 


Ser Met Ser Phe Lys Asn Leu Ser Met Leu Leu Leu Leu Thr Trp Pro 
                245                 250                 255     


Tyr Ile Leu Leu Gly Phe Leu Phe Cys Ala Phe Val Val Val Asn Gly 
            260                 265                 270         


Gly Ile Val Ile Gly Asp Arg Ser Ser His Glu Ala Cys Leu His Phe 
        275                 280                 285             


Pro Gln Leu Phe Tyr Phe Phe Ser Phe Thr Leu Phe Phe Ser Phe Pro 
    290                 295                 300                 


His Leu Leu Ser Pro Ser Lys Ile Lys Thr Phe Leu Ser Leu Val Trp 
305                 310                 315                 320 


Lys Arg Arg Ile Leu Phe Phe Val Val Thr Leu Val Ser Val Phe Leu 
                325                 330                 335     


Val Trp Lys Phe Thr Tyr Ala His Lys Tyr Leu Leu Ala Asp Asn Arg 
            340                 345                 350         


His Tyr Thr Phe Tyr Val Trp Lys Arg Val Phe Gln Arg Tyr Glu Thr 
        355                 360                 365             


Val Lys Tyr Leu Leu Val Pro Ala Tyr Ile Phe Ala Gly Trp Ser Ile 
    370                 375                 380                 


Ala Asp Ser Leu Lys Ser Lys Ser Ile Phe Trp Asn Leu Met Phe Phe 
385                 390                 395                 400 


Ile Cys Leu Phe Thr Val Ile Val Pro Gln Lys Leu Leu Glu Phe Arg 
                405                 410                 415     


Tyr Phe Ile Leu Pro Tyr Val Ile Tyr Arg Leu Asn Ile Pro Leu Pro 
            420                 425                 430         


Pro Thr Ser Arg Leu Ile Cys Glu Leu Ser Cys Tyr Ala Val Val Asn 
        435                 440                 445             


Phe Ile Thr Phe Phe Ile Phe Leu Asn Lys Thr Phe Gln Trp Pro Asn 
    450                 455                 460                 


Ser Gln Asp Ile Gln Arg Phe Met Trp 
465                 470             


<210>  5416
<211>  561
<212>  PRT
<213>  Homo sapiens

<400>  5416

Met Met Gln Gly Glu Ala His Pro Ser Ala Ser Leu Ile Asp Arg Thr 
1               5                   10                  15      


Ile Lys Met Arg Lys Glu Thr Glu Ala Arg Lys Val Val Leu Ala Trp 
            20                  25                  30          


Gly Leu Leu Asn Val Ser Met Ala Gly Met Ile Tyr Thr Glu Met Thr 
        35                  40                  45              


Gly Lys Leu Ile Ser Ser Tyr Tyr Asn Val Thr Tyr Trp Pro Leu Trp 
    50                  55                  60                  


Tyr Ile Glu Leu Ala Leu Ala Ser Leu Phe Ser Leu Asn Ala Leu Phe 
65                  70                  75                  80  


Asp Phe Trp Arg Tyr Phe Lys Tyr Thr Val Ala Pro Thr Ser Leu Val 
                85                  90                  95      


Val Ser Pro Gly Gln Gln Thr Leu Leu Gly Leu Lys Thr Ala Val Val 
            100                 105                 110         


Gln Thr Thr Pro Pro His Asp Leu Ala Ala Thr Gln Ile Pro Pro Ala 
        115                 120                 125             


Pro Pro Ser Pro Ser Ile Gln Gly Gln Ser Val Leu Ser Tyr Ser Pro 
    130                 135                 140                 


Ser Arg Ser Pro Ser Thr Ser Pro Lys Phe Thr Thr Ser Cys Met Thr 
145                 150                 155                 160 


Gly Tyr Ser Pro Gln Leu Gln Gly Leu Ser Ser Gly Gly Ser Gly Ser 
                165                 170                 175     


Tyr Ser Pro Gly Val Thr Tyr Ser Pro Val Ser Gly Tyr Asn Lys Leu 
            180                 185                 190         


Ala Ser Phe Ser Pro Ser Pro Pro Ser Pro Tyr Pro Thr Thr Val Gly 
        195                 200                 205             


Pro Val Glu Ser Ser Gly Leu Arg Ser Arg Tyr Arg Ser Ser Pro Thr 
    210                 215                 220                 


Val Tyr Asn Ser Pro Thr Asp Lys Glu Asp Tyr Met Thr Asp Leu Arg 
225                 230                 235                 240 


Thr Leu Asp Thr Phe Leu Arg Ser Glu Glu Glu Lys Gln His Arg Val 
                245                 250                 255     


Lys Leu Gly Ser Pro Asp Ser Thr Ser Pro Ser Ser Ser Pro Thr Phe 
            260                 265                 270         


Trp Asn Tyr Ser Arg Ser Met Gly Asp Tyr Ala Gln Thr Leu Lys Lys 
        275                 280                 285             


Phe Gln Tyr Gln Leu Ala Cys Arg Ser Gln Ala Pro Cys Ala Asn Lys 
    290                 295                 300                 


Asp Glu Ala Asp Leu Ser Ser Lys Gln Ala Ala Glu Glu Val Trp Ala 
305                 310                 315                 320 


Arg Val Ala Met Asn Arg Gln Leu Leu Asp His Met Asp Ser Trp Thr 
                325                 330                 335     


Ala Lys Phe Arg Asn Trp Ile Asn Glu Thr Ile Leu Val Pro Leu Val 
            340                 345                 350         


Gln Glu Ile Glu Ser Val Ser Thr Gln Met Arg Arg Met Gly Cys Pro 
        355                 360                 365             


Glu Leu Gln Ile Gly Glu Ala Ser Ile Thr Ser Leu Lys Gln Ala Ala 
    370                 375                 380                 


Leu Val Lys Ala Pro Leu Ile Pro Thr Leu Asn Thr Ile Val Gln Tyr 
385                 390                 395                 400 


Leu Asp Leu Thr Pro Asn Gln Glu Tyr Leu Phe Glu Arg Ile Lys Glu 
                405                 410                 415     


Leu Ser Gln Gly Gly Cys Met Ser Ser Phe Arg Trp Asn Arg Gly Gly 
            420                 425                 430         


Asp Phe Lys Gly Arg Lys Trp Asp Thr Asp Leu Pro Thr Asp Ser Ala 
        435                 440                 445             


Ile Ile Met His Val Phe Cys Thr Tyr Leu Asp Ser Arg Leu Pro Pro 
    450                 455                 460                 


His Pro Lys Tyr Pro Asp Gly Lys Thr Phe Thr Ser Gln His Phe Val 
465                 470                 475                 480 


Gln Thr Pro Asn Lys Pro Asp Val Thr Asn Glu Asn Val Phe Cys Ile 
                485                 490                 495     


Tyr Gln Ser Ala Ile Asn Pro Pro His Tyr Glu Leu Ile Tyr Gln Arg 
            500                 505                 510         


His Val Tyr Asn Leu Pro Lys Gly Arg Asn Asn Met Phe His Thr Leu 
        515                 520                 525             


Leu Met Phe Leu Tyr Ile Ile Lys Thr Lys Glu Ser Gly Met Leu Gly 
    530                 535                 540                 


Arg Val Asn Leu Gly Leu Ser Gly Val Asn Ile Leu Trp Ile Phe Gly 
545                 550                 555                 560 


Glu 
    


<210>  5417
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  5417

Met Val Asn Asp Arg Trp Lys Thr Met Gly Gly Ala Ala Gln Leu Glu 
1               5                   10                  15      


Asp Arg Pro Arg Asp Lys Pro Gln Arg Pro Ser Cys Gly Tyr Val Leu 
            20                  25                  30          


Cys Thr Val Leu Leu Ala Leu Ala Val Leu Leu Ala Val Ala Val Thr 
        35                  40                  45              


Gly Ala Val Leu Phe Leu Asn His Ala His Ala Pro Gly Thr Ala Pro 
    50                  55                  60                  


Pro Pro Val Val Ser Thr Gly Ala Ala Ser Ala Asn Ser Ala Leu Val 
65                  70                  75                  80  


Thr Val Glu Arg Ala Asp Ser Ser His Leu Ser Ile Leu Ile Asp Pro 
                85                  90                  95      


Arg Cys Pro Asp Leu Thr Asp Ser Phe Ala Arg Leu Glu Ser Ala Gln 
            100                 105                 110         


Ala Ser Val Leu Gln Ala Leu Thr Glu His Gln Ala Gln Pro Arg Leu 
        115                 120                 125             


Val Gly Asp Gln Glu Gln Glu Leu Leu Asp Thr Leu Ala Asp Gln Leu 
    130                 135                 140                 


Pro Arg Leu Leu Ala Arg Ala Ser Glu Leu Gln Thr Glu Cys Met Gly 
145                 150                 155                 160 


Leu Arg Lys Gly His Gly Thr Leu Gly Gln Gly Leu Ser Ala Leu Gln 
                165                 170                 175     


Ser Glu Gln Gly Arg Leu Ile Gln Leu Leu Ser Glu Ser Gln Gly His 
            180                 185                 190         


Met Ala His Leu Val Asn Ser Val Ser Asp Ile Leu Asp Ala Leu Gln 
        195                 200                 205             


Arg Asp Arg Gly Leu Gly Arg Pro Arg Asn Lys Ala Asp Leu Gln Arg 
    210                 215                 220                 


Ala Pro Ala Arg Gly Thr Arg Pro Arg Gly Cys Ala Thr Gly Ser Arg 
225                 230                 235                 240 


Pro Arg Asp Cys Leu Asp Val Leu Leu Ser Gly Gln Gln Asp Asp Gly 
                245                 250                 255     


Val Tyr Ser Val Phe Pro Thr His Tyr Pro Ala Gly Phe Gln Val Tyr 
            260                 265                 270         


Cys Asp Met Arg Thr Asp Gly Gly Gly Trp Thr Val Phe Gln Arg Arg 
        275                 280                 285             


Glu Asp Gly Ser Val Asn Phe Phe Arg Gly Trp Asp Ala Tyr Arg Asp 
    290                 295                 300                 


Gly Phe Gly Arg Leu Thr Gly Glu His Trp Leu Gly Leu Lys Arg Ile 
305                 310                 315                 320 


His Ala Leu Thr Thr Gln Ala Ala Tyr Glu Leu His Val Asp Leu Glu 
                325                 330                 335     


Asp Phe Glu Asn Gly Thr Ala Tyr Ala Arg Tyr Gly Ser Phe Gly Val 
            340                 345                 350         


Gly Leu Phe Ser Val Asp Pro Glu Glu Asp Gly Tyr Pro Leu Thr Val 
        355                 360                 365             


Ala Asp Tyr Ser Gly Thr Ala Gly Asp Ser Leu Leu Lys His Ser Gly 
    370                 375                 380                 


Met Arg Phe Thr Thr Lys Asp Arg Asp Ser Asp His Ser Glu Asn Asn 
385                 390                 395                 400 


Cys Ala Ala Phe Tyr Arg Gly Ala Trp Trp Tyr Arg Asn Cys His Thr 
                405                 410                 415     


Ser Asn Leu Asn Gly Gln Tyr Leu Arg Gly Ala His Ala Ser Tyr Ala 
            420                 425                 430         


Asp Gly Val Glu Trp Ser Ser Trp Thr Gly Trp Gln Tyr Ser Leu Lys 
        435                 440                 445             


Phe Ser Glu Met Lys Ile Arg Pro Val Arg Glu Asp Arg 
    450                 455                 460     


<210>  5418
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  5418

Met Glu Lys Ser Trp Met Leu Trp Asn Phe Val Glu Arg Trp Leu Ile 
1               5                   10                  15      


Ala Leu Ala Ser Trp Ser Trp Ala Leu Cys Arg Ile Ser Leu Leu Pro 
            20                  25                  30          


Leu Ile Val Thr Phe His Leu Tyr Gly Gly Ile Ile Leu Leu Leu Leu 
        35                  40                  45              


Ile Phe Ile Ser Ile Ala Gly Ile Leu Tyr Lys Phe Gln Asp Val Leu 
    50                  55                  60                  


Leu Tyr Phe Pro Glu Gln Pro Ser Ser Ser Arg Leu Tyr Val Pro Met 
65                  70                  75                  80  


Pro Thr Gly Ile Pro His Glu Asn Ile Phe Ile Arg Thr Lys Asp Gly 
                85                  90                  95      


Ile Arg Leu Asn Leu Ile Leu Ile Arg Tyr Thr Gly Asp Asn Ser Pro 
            100                 105                 110         


Tyr Ser Pro Thr Ile Ile Tyr Phe His Gly Asn Ala Gly Asn Ile Gly 
        115                 120                 125             


His Arg Leu Pro Asn Ala Leu Leu Met Leu Val Asn Leu Lys Val Asn 
    130                 135                 140                 


Leu Leu Leu Val Asp Tyr Arg Gly Tyr Gly Lys Ser Glu Gly Glu Ala 
145                 150                 155                 160 


Ser Glu Glu Gly Leu Tyr Leu Asp Ser Glu Ala Val Leu Asp Tyr Val 
                165                 170                 175     


Met Thr Arg Pro Asp Leu Asp Lys Thr Lys Ile Phe Leu Phe Gly Arg 
            180                 185                 190         


Ser Leu Gly Gly Ala Val Ala Ile His Leu Ala Ser Glu Asn Ser His 
        195                 200                 205             


Arg Ile Ser Ala Ile Met Val Glu Asn Thr Phe Leu Ser Ile Pro His 
    210                 215                 220                 


Met Ala Ser Thr Leu Phe Ser Phe Phe Pro Met Arg Tyr Leu Pro Leu 
225                 230                 235                 240 


Trp Cys Tyr Lys Asn Lys Phe Leu Ser Tyr Arg Lys Ile Ser Gln Cys 
                245                 250                 255     


Arg Met Pro Ser Leu Phe Ile Ser Gly Leu Ser Asp Gln Leu Ile Pro 
            260                 265                 270         


Pro Val Met Met Lys Gln Leu Tyr Glu Leu Ser Pro Ser Arg Thr Lys 
        275                 280                 285             


Arg Leu Ala Ile Phe Pro Asp Gly Thr His Asn Asp Thr Trp Gln Cys 
    290                 295                 300                 


Gln Gly Tyr Phe Thr Ala Leu Glu Gln Phe Ile Lys Glu Val Val Lys 
305                 310                 315                 320 


Ser His Ser Pro Glu Glu Met Ala Lys Thr Ser Ser Asn Val Thr Ile 
                325                 330                 335     


Ile 
    


<210>  5419
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  5419

Met Lys Pro Ser Leu Leu Cys Arg Pro Leu Ser Cys Phe Leu Met Leu 
1               5                   10                  15      


Leu Pro Trp Pro Leu Ala Thr Leu Thr Ser Thr Thr Leu Trp Gln Cys 
            20                  25                  30          


Pro Pro Gly Glu Glu Pro Asp Leu Asp Pro Gly Gln Gly Thr Leu Cys 
        35                  40                  45              


Arg Pro Cys Pro Pro Gly Thr Phe Ser Ala Ala Trp Gly Ser Ser Pro 
    50                  55                  60                  


Cys Gln Pro His Ala Arg Cys Ser Leu Trp Arg Arg Leu Glu Ala Gln 
65                  70                  75                  80  


Val Gly Met Ala Thr Arg Asp Thr Leu Cys Gly Asp Cys Trp Pro Gly 
                85                  90                  95      


Trp Phe Gly Pro Trp Gly Val Pro Arg Val Pro Cys Gln Pro Cys Ser 
            100                 105                 110         


Trp Ala Pro Leu Gly Thr His Gly Cys Asp Glu Trp Gly Arg Arg Ala 
        115                 120                 125             


Arg Arg Gly Val Glu Val Ala Ala Gly Ala Ser Ser Gly Gly Glu Thr 
    130                 135                 140                 


Arg Gln Pro Gly Asn Gly Thr Arg Ala Gly Gly Pro Glu Glu Thr Ala 
145                 150                 155                 160 


Ala Gln Tyr Ala Val Ile Ala Ile Val Pro Val Phe Cys Leu Met Gly 
                165                 170                 175     


Leu Leu Gly Ile Leu Val Cys Asn Leu Leu Lys Arg Lys Gly Tyr His 
            180                 185                 190         


Cys Thr Ala His Lys Glu Val Gly Pro Gly Pro Gly Gly Gly Gly Ser 
        195                 200                 205             


Gly Ile Asn Pro Ala Tyr Arg Thr Glu Asp Ala Asn Glu Asp Thr Ile 
    210                 215                 220                 


Gly Val Leu Val Arg Leu Ile Thr Glu Lys Lys Glu Asn Ala Ala Ala 
225                 230                 235                 240 


Leu Glu Glu Leu Leu Lys Glu Tyr His Ser Lys Gln Leu Val Gln Thr 
                245                 250                 255     


Ser His Arg Pro Val Ser Lys Leu Pro Pro Ala Pro Pro Asn Val Pro 
            260                 265                 270         


His Ile Cys Pro His Arg His His Leu His Thr Val Gln Gly Leu Ala 
        275                 280                 285             


Ser Leu Ser Gly Pro Cys Cys Ser Arg Cys Ser Gln Lys Lys Trp Pro 
    290                 295                 300                 


Glu Val Leu Leu Ser Pro Glu Ala Val Ala Ala Thr Thr Pro Val Pro 
305                 310                 315                 320 


Ser Leu Leu Pro Asn Pro Thr Arg Val Pro Lys Ala Gly Ala Lys Ala 
                325                 330                 335     


Gly Arg Gln Gly Glu Ile Thr Ile Leu Ser Val Gly Arg Phe Arg Val 
            340                 345                 350         


Ala Arg Ile Pro Glu Gln Arg Thr Ser Ser Met Val Ser Glu Val Lys 
        355                 360                 365             


Thr Ile Thr Glu Ala Gly Pro Ser Trp Gly Asp Leu Pro Asp Ser Pro 
    370                 375                 380                 


Gln Pro Gly Leu Pro Pro Glu Gln Gln Ala Leu Leu Gly Ser Gly Gly 
385                 390                 395                 400 


Ser Arg Thr Lys Trp Leu Lys Pro Pro Ala Glu Asn Lys Ala Glu Glu 
                405                 410                 415     


Asn Arg Tyr Val Val Arg Leu Ser Glu Ser Asn Leu Val Ile 
            420                 425                 430 


<210>  5420
<211>  1524
<212>  PRT
<213>  Homo sapiens

<400>  5420

Met Ala Met Ser Asn Gly Asn Asn Asp Phe Val Val Leu Ser Asn Ser 
1               5                   10                  15      


Ser Ile Ala Thr Ser Ala Ala Asn Pro Ser Pro Leu Thr Pro Cys Asp 
            20                  25                  30          


Gly Asp His Ala Ala Gln Gln Leu Thr Pro Lys Glu Ala Thr Arg Thr 
        35                  40                  45              


Lys Val Ser Pro Asn Gly Cys Leu Gln Leu Asn Gly Thr Val Lys Ser 
    50                  55                  60                  


Ser Phe Leu Pro Leu Asp Asn Gln Arg Met Pro Gln Met Leu Pro Gln 
65                  70                  75                  80  


Cys Cys His Pro Cys Pro Tyr His His Pro Leu Thr Ser His Ser Ser 
                85                  90                  95      


His Gln Glu Cys His Pro Glu Ala Gly Pro Ala Ala Pro Ser Ala Leu 
            100                 105                 110         


Ala Ser Cys Cys Met Gln Pro His Ser Glu Tyr Ser Ala Ser Leu Cys 
        115                 120                 125             


Pro Asn His Ser Pro Val Tyr Gln Thr Thr Cys Cys Leu Gln Pro Ser 
    130                 135                 140                 


Pro Ser Phe Cys Leu His His Pro Trp Pro Asp His Phe Gln His Gln 
145                 150                 155                 160 


Pro Val Gln Gln His Ile Ala Asn Ile Arg Pro Ser Arg Pro Phe Lys 
                165                 170                 175     


Leu Pro Lys Ser Tyr Ala Ala Leu Ile Ala Asp Trp Pro Val Val Val 
            180                 185                 190         


Leu Gly Met Cys Thr Met Phe Ile Val Val Cys Ala Leu Val Gly Val 
        195                 200                 205             


Leu Val Pro Glu Leu Pro Asp Phe Ser Asp Pro Leu Leu Gly Phe Glu 
    210                 215                 220                 


Pro Arg Gly Thr Ala Ile Gly Gln Arg Leu Val Thr Trp Asn Asn Met 
225                 230                 235                 240 


Val Lys Asn Thr Gly Tyr Lys Ala Thr Leu Ala Asn Tyr Pro Phe Lys 
                245                 250                 255     


Tyr Ala Asp Glu Gln Ala Lys Ser His Arg Asp Asp Arg Trp Ser Asp 
            260                 265                 270         


Asp His Tyr Glu Arg Glu Lys Arg Glu Val Asp Trp Asn Phe His Lys 
        275                 280                 285             


Asp Ser Phe Phe Cys Asp Val Pro Ser Asp Arg Tyr Ser Arg Val Val 
    290                 295                 300                 


Phe Thr Ser Ser Gly Gly Glu Thr Leu Trp Asn Leu Pro Ala Ile Lys 
305                 310                 315                 320 


Ser Met Cys Asn Val Asp Asn Ser Arg Ile Arg Ser His Pro Gln Phe 
                325                 330                 335     


Gly Asp Leu Cys Gln Arg Thr Thr Ala Ala Ser Cys Cys Pro Ser Trp 
            340                 345                 350         


Thr Leu Gly Asn Tyr Ile Ala Ile Leu Asn Asn Arg Ser Ser Cys Gln 
        355                 360                 365             


Lys Ile Val Glu Arg Asp Val Ser His Thr Leu Lys Leu Leu Arg Thr 
    370                 375                 380                 


Cys Ala Lys His Tyr Gln Asn Gly Thr Leu Gly Pro Asp Cys Trp Asp 
385                 390                 395                 400 


Met Ala Ala Arg Arg Lys Asp Gln Leu Lys Cys Thr Asn Val Pro Arg 
                405                 410                 415     


Lys Cys Thr Lys Tyr Asn Ala Val Tyr Gln Ile Leu His Tyr Leu Val 
            420                 425                 430         


Asp Lys Asp Phe Met Thr Pro Lys Thr Ala Asp Tyr Ala Thr Pro Ala 
        435                 440                 445             


Leu Lys Tyr Ser Met Leu Phe Ser Pro Thr Glu Lys Gly Glu Ser Met 
    450                 455                 460                 


Met Asn Ile Tyr Leu Asp Asn Phe Glu Asn Trp Asn Ser Ser Asp Gly 
465                 470                 475                 480 


Val Thr Thr Ile Thr Gly Ile Glu Phe Gly Ile Lys His Ser Leu Phe 
                485                 490                 495     


Gln Asp Tyr Leu Leu Met Asp Thr Val Tyr Pro Ala Ile Ala Ile Val 
            500                 505                 510         


Ile Val Leu Leu Val Met Cys Val Tyr Thr Lys Ser Met Phe Ile Thr 
        515                 520                 525             


Leu Met Thr Met Phe Ala Ile Ile Ser Ser Leu Ile Val Ser Tyr Phe 
    530                 535                 540                 


Leu Tyr Arg Val Val Phe His Phe Glu Phe Phe Pro Phe Met Asn Leu 
545                 550                 555                 560 


Thr Ala Leu Ile Ile Leu Val Gly Ile Gly Ala Asp Asp Ala Phe Val 
                565                 570                 575     


Leu Cys Asp Val Trp Asn Tyr Thr Lys Phe Asp Lys Pro His Ala Glu 
            580                 585                 590         


Thr Ser Glu Thr Val Ser Ile Thr Leu Gln His Ala Ala Leu Ser Met 
        595                 600                 605             


Phe Val Thr Ser Phe Thr Thr Ala Ala Ala Phe Tyr Ala Asn Tyr Val 
    610                 615                 620                 


Ser Asn Ile Thr Ala Ile Arg Cys Phe Gly Val Tyr Ala Gly Thr Ala 
625                 630                 635                 640 


Ile Leu Val Asn Tyr Val Leu Met Val Thr Trp Leu Pro Ala Val Val 
                645                 650                 655     


Val Leu His Glu Arg Tyr Leu Leu Asn Ile Phe Thr Cys Phe Lys Lys 
            660                 665                 670         


Pro Gln Gln Gln Ile Tyr Asp Asn Lys Ser Cys Trp Thr Val Ala Cys 
        675                 680                 685             


Gln Lys Cys His Lys Val Leu Phe Ala Ile Ser Glu Ala Ser Arg Ile 
    690                 695                 700                 


Phe Phe Glu Lys Val Leu Pro Cys Ile Val Ile Lys Phe Arg Tyr Leu 
705                 710                 715                 720 


Trp Leu Phe Trp Phe Leu Ala Leu Thr Val Gly Gly Ala Tyr Ile Val 
                725                 730                 735     


Cys Ile Asn Pro Lys Met Lys Leu Pro Ser Leu Glu Leu Ser Glu Phe 
            740                 745                 750         


Gln Val Phe Arg Ser Ser His Pro Phe Glu Arg Tyr Asp Ala Glu Tyr 
        755                 760                 765             


Lys Lys Leu Phe Met Phe Glu Arg Val His His Gly Glu Glu Leu His 
    770                 775                 780                 


Met Pro Ile Thr Val Ile Trp Gly Val Ser Pro Glu Asp Asn Gly Asn 
785                 790                 795                 800 


Pro Leu Asn Pro Lys Ser Lys Gly Lys Leu Thr Leu Asp Ser Ser Phe 
                805                 810                 815     


Asn Ile Ala Ser Pro Ala Ser Gln Ala Trp Ile Leu His Phe Cys Gln 
            820                 825                 830         


Lys Leu Arg Asn Gln Thr Phe Phe Tyr Gln Thr Asp Glu Gln Asp Phe 
        835                 840                 845             


Thr Ser Cys Phe Ile Glu Thr Phe Lys Gln Trp Met Glu Asn Gln Asp 
    850                 855                 860                 


Cys Asp Glu Pro Ala Leu Tyr Pro Cys Cys Ser His Trp Ser Phe Pro 
865                 870                 875                 880 


Tyr Lys Gln Glu Ile Phe Glu Leu Cys Ile Lys Arg Ala Ile Met Glu 
                885                 890                 895     


Leu Glu Arg Ser Thr Gly Tyr His Leu Asp Ser Lys Thr Pro Gly Pro 
            900                 905                 910         


Arg Phe Asp Ile Asn Asp Thr Ile Arg Ala Val Val Leu Glu Phe Gln 
        915                 920                 925             


Ser Thr Tyr Leu Phe Thr Leu Ala Tyr Glu Lys Met His Gln Phe Tyr 
    930                 935                 940                 


Lys Glu Val Asp Ser Trp Ile Ser Ser Glu Leu Ser Ser Ala Pro Glu 
945                 950                 955                 960 


Gly Leu Ser Asn Gly Trp Phe Val Ser Asn Leu Glu Phe Tyr Asp Leu 
                965                 970                 975     


Gln Asp Ser Leu Ser Asp Gly Thr Leu Ile Ala Met Gly Leu Ser Val 
            980                 985                 990         


Ala Val Ala Phe Ser Val Met Leu  Leu Thr Thr Trp Asn  Ile Ile Ile 
        995                 1000                 1005             


Ser Leu  Tyr Ala Ile Ile Ser  Ile Ala Gly Thr Ile  Phe Val Thr 
    1010                 1015                 1020             


Val Gly  Ser Leu Val Leu Leu  Gly Trp Glu Leu Asn  Val Leu Glu 
    1025                 1030                 1035             


Ser Val  Thr Ile Ser Val Ala  Val Gly Leu Ser Val  Asp Phe Ala 
    1040                 1045                 1050             


Val His  Tyr Gly Val Ala Tyr  Arg Leu Ala Pro Asp  Pro Asp Arg 
    1055                 1060                 1065             


Glu Gly  Lys Val Ile Phe Ser  Leu Ser Arg Val Gly  Ser Ala Met 
    1070                 1075                 1080             


Ala Met  Ala Ala Leu Thr Thr  Phe Val Ala Gly Ala  Met Met Met 
    1085                 1090                 1095             


Pro Ser  Thr Val Leu Ala Tyr  Thr Gln Leu Gly Thr  Phe Met Met 
    1100                 1105                 1110             


Leu Ile  Met Cys Ile Ser Trp  Ala Phe Ala Thr Phe  Phe Phe Gln 
    1115                 1120                 1125             


Cys Met  Cys Arg Cys Leu Gly  Pro Gln Gly Thr Cys  Gly Gln Ile 
    1130                 1135                 1140             


Pro Leu  Pro Lys Lys Leu Gln  Cys Ser Ala Phe Ser  His Ala Leu 
    1145                 1150                 1155             


Ser Thr  Ser Pro Ser Asp Lys  Gly Gln Ser Lys Thr  His Thr Ile 
    1160                 1165                 1170             


Asn Ala  Tyr His Leu Asp Pro  Arg Gly Pro Lys Ser  Glu Leu Glu 
    1175                 1180                 1185             


His Glu  Phe Tyr Glu Leu Glu  Pro Leu Ala Ser His  Ser Cys Thr 
    1190                 1195                 1200             


Ala Pro  Glu Lys Thr Thr Tyr  Glu Glu Thr His Ile  Cys Ser Glu 
    1205                 1210                 1215             


Phe Phe  Asn Ser Gln Ala Lys  Asn Leu Gly Met Pro  Val His Ala 
    1220                 1225                 1230             


Ala Tyr  Asn Ser Glu Leu Ser  Lys Ser Thr Glu Ser  Asp Ala Gly 
    1235                 1240                 1245             


Ser Ala  Leu Leu Gln Pro Pro  Leu Glu Gln His Thr  Val Cys His 
    1250                 1255                 1260             


Phe Phe  Ser Leu Asn Gln Arg  Cys Ser Cys Pro Asp  Ala Tyr Lys 
    1265                 1270                 1275             


His Leu  Asn Tyr Gly Pro His  Ser Cys Gln Gln Met  Gly Asp Cys 
    1280                 1285                 1290             


Leu Cys  His Gln Cys Ser Pro  Thr Thr Ser Ser Phe  Val Gln Ile 
    1295                 1300                 1305             


Gln Asn  Gly Val Ala Pro Leu  Lys Ala Thr His Gln  Ala Val Glu 
    1310                 1315                 1320             


Gly Phe  Val His Pro Ile Thr  His Ile His His Cys  Pro Cys Leu 
    1325                 1330                 1335             


Gln Gly  Arg Val Lys Pro Ala  Gly Met Gln Asn Ser  Leu Pro Arg 
    1340                 1345                 1350             


Asn Phe  Phe Leu His Pro Val  Gln His Ile Gln Ala  Gln Glu Lys 
    1355                 1360                 1365             


Ile Gly  Lys Thr Asn Val His  Ser Leu Gln Arg Ser  Ile Glu Glu 
    1370                 1375                 1380             


His Leu  Pro Lys Met Ala Glu  Pro Ser Ser Phe Val  Cys Arg Ser 
    1385                 1390                 1395             


Thr Gly  Ser Leu Leu Lys Thr  Cys Cys Asp Pro Glu  Asn Lys Gln 
    1400                 1405                 1410             


Arg Glu  Leu Cys Lys Asn Arg  Asp Val Ser Asn Leu  Glu Ser Ser 
    1415                 1420                 1425             


Gly Gly  Thr Glu Asn Lys Ala  Gly Gly Lys Val Glu  Leu Ser Leu 
    1430                 1435                 1440             


Ser Gln  Thr Asp Ala Ser Val  Asn Ser Glu His Phe  Asn Gln Asn 
    1445                 1450                 1455             


Glu Pro  Lys Val Leu Phe Asn  His Leu Met Gly Glu  Ala Gly Cys 
    1460                 1465                 1470             


Arg Ser  Cys Pro Asn Asn Ser  Gln Ser Cys Gly Arg  Ile Val Arg 
    1475                 1480                 1485             


Val Lys  Cys Asn Ser Val Asp  Cys Gln Met Pro Asn  Met Glu Ala 
    1490                 1495                 1500             


Asn Val  Pro Ala Val Leu Thr  His Ser Glu Leu Ser  Gly Glu Ser 
    1505                 1510                 1515             


Leu Leu  Ile Lys Thr Leu 
    1520                 


<210>  5421
<211>  570
<212>  PRT
<213>  Homo sapiens

<400>  5421

Met Leu Ser Arg Leu Met Ser Gly Ser Ser Arg Ser Leu Glu Arg Glu 
1               5                   10                  15      


Tyr Ser Cys Thr Val Arg Leu Leu Asp Asp Ser Glu Tyr Thr Cys Thr 
            20                  25                  30          


Ile Gln Arg Asp Ala Lys Gly Gln Tyr Leu Phe Asp Leu Leu Cys His 
        35                  40                  45              


His Leu Asn Leu Leu Glu Lys Asp Tyr Phe Gly Ile Arg Phe Val Asp 
    50                  55                  60                  


Pro Asp Lys Gln Arg His Trp Leu Glu Phe Thr Lys Ser Val Val Lys 
65                  70                  75                  80  


Gln Leu Arg Ser Gln Pro Pro Phe Thr Met Cys Phe Arg Val Lys Phe 
                85                  90                  95      


Tyr Pro Ala Asp Pro Ala Ala Leu Lys Glu Glu Ile Thr Arg Tyr Leu 
            100                 105                 110         


Val Phe Leu Gln Ile Lys Arg Asp Leu Tyr His Gly Arg Leu Leu Cys 
        115                 120                 125             


Lys Thr Ser Asp Ala Ala Leu Leu Ala Ala Tyr Ile Leu Gln Ala Glu 
    130                 135                 140                 


Ile Gly Asp Tyr Asp Ser Gly Lys His Pro Glu Gly Tyr Ser Ser Lys 
145                 150                 155                 160 


Phe Gln Phe Phe Pro Lys His Ser Glu Lys Leu Glu Arg Lys Ile Ala 
                165                 170                 175     


Glu Ile His Lys Thr Glu Leu Ser Gly Gln Thr Pro Ala Thr Ser Glu 
            180                 185                 190         


Leu Asn Phe Leu Arg Lys Ala Gln Thr Leu Glu Thr Tyr Gly Val Asp 
        195                 200                 205             


Pro His Pro Cys Lys Asp Val Ser Gly Asn Ala Ala Phe Leu Ala Phe 
    210                 215                 220                 


Thr Pro Phe Gly Phe Val Val Leu Gln Gly Asn Lys Arg Val His Phe 
225                 230                 235                 240 


Ile Lys Trp Asn Glu Val Thr Lys Leu Lys Phe Glu Gly Lys Thr Phe 
                245                 250                 255     


Tyr Leu Tyr Val Ser Gln Lys Glu Glu Lys Lys Ile Ile Leu Thr Tyr 
            260                 265                 270         


Phe Ala Pro Thr Pro Glu Ala Cys Lys His Leu Trp Lys Cys Gly Ile 
        275                 280                 285             


Glu Asn Gln Ala Phe Tyr Lys Leu Glu Lys Ser Ser Gln Val Arg Thr 
    290                 295                 300                 


Val Ser Ser Ser Asn Leu Phe Phe Lys Gly Ser Arg Phe Arg Tyr Ser 
305                 310                 315                 320 


Gly Arg Val Ala Lys Glu Val Met Glu Ser Ser Ala Lys Ile Lys Arg 
                325                 330                 335     


Glu Pro Pro Glu Ile His Arg Ala Gly Met Val Pro Ser Arg Ser Cys 
            340                 345                 350         


Pro Ser Ile Thr His Gly Pro Arg Leu Ser Ser Val Pro Arg Thr Arg 
        355                 360                 365             


Arg Arg Ala Val His Ile Ser Ile Met Glu Gly Leu Glu Ser Leu Arg 
    370                 375                 380                 


Asp Ser Ala His Ser Thr Pro Val Arg Ser Thr Ser His Gly Asp Thr 
385                 390                 395                 400 


Phe Leu Pro His Val Arg Ser Ser Arg Thr Asp Ser Asn Glu Arg Val 
                405                 410                 415     


Ala Val Ile Ala Asp Glu Ala Tyr Ser Pro Ala Asp Ser Val Leu Pro 
            420                 425                 430         


Thr Pro Val Ala Glu His Ser Leu Glu Leu Met Leu Leu Ser Arg Gln 
        435                 440                 445             


Ile Asn Gly Ala Thr Cys Ser Ile Glu Glu Glu Lys Glu Ser Glu Ala 
    450                 455                 460                 


Ser Thr Pro Thr Ala Thr Glu Val Glu Ala Leu Gly Gly Glu Leu Arg 
465                 470                 475                 480 


Ala Leu Cys Gln Gly His Ser Gly Pro Glu Glu Glu Gln Val Asn Lys 
                485                 490                 495     


Phe Val Leu Ser Val Leu Arg Leu Leu Leu Val Thr Met Gly Leu Leu 
            500                 505                 510         


Phe Val Leu Leu Leu Leu Leu Ile Ile Leu Thr Glu Ser Asp Leu Asp 
        515                 520                 525             


Ile Ala Phe Phe Arg Asp Ile Arg Gln Thr Pro Glu Phe Glu Gln Phe 
    530                 535                 540                 


His Tyr Gln Tyr Phe Cys Pro Leu Arg Arg Trp Phe Ala Cys Lys Ile 
545                 550                 555                 560 


Arg Ser Val Val Ser Leu Leu Ile Asp Thr 
                565                 570 


<210>  5422
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  5422

Met Pro Thr Gly Lys Gln Leu Ala Asp Ile Gly Tyr Lys Thr Phe Ser 
1               5                   10                  15      


Thr Ser Met Met Leu Leu Thr Val Tyr Gly Gly Tyr Leu Cys Ser Val 
            20                  25                  30          


Arg Val Tyr His Tyr Phe Gln Trp Arg Arg Ala Gln Arg Gln Ala Ala 
        35                  40                  45              


Glu Glu Gln Lys Thr Ser Gly Ile Met 
    50                  55          


<210>  5423
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  5423

Met Pro Pro Phe Gly Tyr Lys Thr Glu Thr Ser Thr Ala Val Glu Lys 
1               5                   10                  15      


Lys Glu Lys Pro Leu Pro Arg Leu Asn Ile His Ser Gly Phe Trp Ile 
            20                  25                  30          


Leu Ala Ser Ile Val Val Thr Tyr Tyr Val Asp Phe Phe Lys Thr Leu 
        35                  40                  45              


Lys Glu Asn Phe His Thr Ser Ser Trp Phe Leu Cys Gly Ser Ala Leu 
    50                  55                  60                  


Leu Leu Val Ser Leu Ser Ile Ala Phe Tyr Cys Ile Val Tyr Leu Glu 
65                  70                  75                  80  


Trp Tyr Cys Gly Ile Gly Glu Tyr Asp Val Lys Tyr Pro Ala Leu Ile 
                85                  90                  95      


Pro Ile Thr Thr Ala Ser Phe Ile Ala Ala Gly Ile Cys Phe Asn Ile 
            100                 105                 110         


Ala Leu Trp His Val Trp Ser Phe Phe Thr Pro Leu Leu Leu Phe Thr 
        115                 120                 125             


Gln Phe Met Gly Val Val Met Phe Ile Thr Leu Leu Gly 
    130                 135                 140     


<210>  5424
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  5424

Met Val Asn Leu Gly Leu Ser Arg Val Asp Asp Ala Val Ala Ala Lys 
1               5                   10                  15      


His Pro Gly Leu Gly Glu Tyr Ala Ala Cys Gln Ser His Ala Phe Met 
            20                  25                  30          


Lys Gly Val Phe Thr Phe Val Thr Gly Thr Gly Met Ala Phe Gly Leu 
        35                  40                  45              


Gln Met Phe Ile Gln Arg Lys Phe Pro Tyr Pro Leu Gln Trp Ser Leu 
    50                  55                  60                  


Leu Val Ala Val Val Ala Gly Ser Val Val Ser Tyr Gly Val Thr Arg 
65                  70                  75                  80  


Val Glu Ser Glu Lys Cys Asn Asn Leu Trp Leu Phe Leu Glu Thr Gly 
                85                  90                  95      


Gln Leu Pro Lys Asp Arg Ser Thr Asp Gln Arg Ser 
            100                 105             


<210>  5425
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  5425

Met Arg Met Ser Leu Ala Gln Arg Val Leu Leu Thr Trp Leu Phe Thr 
1               5                   10                  15      


Leu Leu Phe Leu Ile Met Leu Val Leu Lys Leu Asp Glu Lys Ala Pro 
            20                  25                  30          


Trp Asn Trp Phe Leu Ile Phe Ile Pro Val Trp Ile Phe Asp Thr Ile 
        35                  40                  45              


Leu Leu Val Leu Leu Ile Val Lys Met Ala Gly Arg Cys Lys Ser Gly 
    50                  55                  60                  


Phe Asp Pro Arg His Gly Ser His Asn Ile Lys Lys Lys Ala Trp Tyr 
65                  70                  75                  80  


Leu Ile Ala Met Leu Leu Lys Leu Ala Phe Cys Leu Ala Leu Cys Ala 
                85                  90                  95      


Lys Leu Glu Gln Phe Thr Thr Met Asn Leu Ser Tyr Val Phe Ile Pro 
            100                 105                 110         


Leu Trp Ala Leu Leu Ala Gly Ala Leu Thr Glu Leu Gly Tyr Asn Val 
        115                 120                 125             


Phe Phe Val Arg Asp 
    130             


<210>  5426
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  5426

Met Asp Ala Val Ser Gln Val Pro Met Glu Val Val Leu Pro Lys His 
1               5                   10                  15      


Ile Leu Asp Ile Trp Val Ile Val Leu Ile Ile Leu Ala Thr Ile Val 
            20                  25                  30          


Ile Met Thr Ser Leu Leu Leu Cys Pro Ala Thr Ala Val Ile Ile Tyr 
        35                  40                  45              


Arg Met Arg Thr His Pro Ile Leu Ser Gly Ala Val 
    50                  55                  60  


<210>  5427
<211>  973
<212>  PRT
<213>  Homo sapiens

<400>  5427

Met Ser Pro Val Arg Arg Trp Gly Ser Pro Cys Leu Phe Pro Leu Gln 
1               5                   10                  15      


Leu Phe Ser Leu Cys Trp Val Leu Ser Val Ala Gln Ser Lys Thr Val 
            20                  25                  30          


Arg Tyr Ser Thr Phe Glu Glu Asp Ala Pro Gly Thr Val Ile Gly Thr 
        35                  40                  45              


Leu Ala Glu Asp Leu His Met Lys Val Ser Gly Asp Thr Ser Phe Arg 
    50                  55                  60                  


Leu Met Lys Gln Phe Asn Ser Ser Leu Leu Arg Val Arg Glu Gly Asp 
65                  70                  75                  80  


Gly Gln Leu Thr Val Gly Asp Ala Gly Leu Asp Arg Glu Arg Leu Cys 
                85                  90                  95      


Gly Gln Ala Pro Gln Cys Val Leu Ala Phe Asp Val Val Ser Phe Ser 
            100                 105                 110         


Gln Glu Gln Phe Arg Leu Val His Val Glu Val Glu Val Arg Asp Val 
        115                 120                 125             


Asn Asp His Ala Pro Arg Phe Pro Arg Ala Gln Ile Pro Val Glu Val 
    130                 135                 140                 


Ser Glu Gly Ala Ala Val Gly Thr Arg Ile Pro Leu Glu Val Pro Val 
145                 150                 155                 160 


Asp Glu Asp Val Gly Ala Asn Gly Leu Gln Thr Val Arg Leu Ala Glu 
                165                 170                 175     


Pro His Ser Pro Phe Arg Val Glu Leu Gln Thr Arg Ala Asp Gly Ala 
            180                 185                 190         


Gln Cys Ala Asp Leu Val Leu Leu Gln Glu Leu Asp Arg Glu Ser Gln 
        195                 200                 205             


Ala Ala Tyr Ser Leu Glu Leu Val Ala Gln Asp Gly Gly Arg Pro Pro 
    210                 215                 220                 


Arg Ser Ala Thr Ala Ala Leu Ser Val Arg Val Leu Asp Ala Asn Asp 
225                 230                 235                 240 


His Ser Pro Ala Phe Pro Gln Gly Ala Val Ala Glu Val Glu Leu Ala 
                245                 250                 255     


Glu Asp Ala Pro Val Gly Ser Leu Leu Leu Asp Leu Asp Ala Ala Asp 
            260                 265                 270         


Pro Asp Glu Gly Pro Asn Gly Asp Val Val Phe Ala Phe Gly Ala Arg 
        275                 280                 285             


Thr Pro Pro Glu Ala Arg Arg Leu Phe Arg Leu Asp Pro Arg Ser Gly 
    290                 295                 300                 


Arg Leu Thr Leu Ala Gly Pro Val Asp Tyr Glu Arg Gln Asp Thr Tyr 
305                 310                 315                 320 


Glu Leu Asp Val Arg Ala Gln Asp Arg Gly Pro Gly Pro Arg Ala Ala 
                325                 330                 335     


Thr Cys Lys Val Ile Val Arg Ile Arg Asp Val Asn Asp Asn Ala Pro 
            340                 345                 350         


Asp Ile Ala Ile Thr Pro Leu Ala Ala Pro Gly Ala Pro Ala Thr Ser 
        355                 360                 365             


Pro Phe Ala Ala Ala Ala Ala Ala Ala Ala Leu Gly Gly Ala Asp Ala 
    370                 375                 380                 


Ser Ser Pro Ala Gly Ala Gly Thr Pro Glu Ala Gly Ala Thr Ser Leu 
385                 390                 395                 400 


Val Pro Glu Gly Ala Ala Arg Glu Ser Leu Val Ala Leu Val Ser Thr 
                405                 410                 415     


Ser Asp Arg Asp Ser Gly Ala Asn Gly Gln Val Arg Cys Ala Leu Tyr 
            420                 425                 430         


Gly His Glu His Phe Arg Leu Gln Pro Ala Tyr Ala Gly Ser Tyr Leu 
        435                 440                 445             


Val Val Thr Ala Ala Ser Leu Asp Arg Glu Arg Ile Ala Glu Tyr Asn 
    450                 455                 460                 


Leu Thr Leu Val Ala Glu Asp Arg Gly Ala Pro Pro Leu Arg Thr Val 
465                 470                 475                 480 


Arg Pro Tyr Thr Val Arg Val Gly Asp Glu Asn Asp Asn Ala Pro Leu 
                485                 490                 495     


Phe Thr Arg Pro Val Tyr Glu Val Ser Val Arg Glu Asn Asn Pro Pro 
            500                 505                 510         


Gly Ala Tyr Leu Ala Thr Val Ala Ala Arg Asp Arg Asp Leu Gly Arg 
        515                 520                 525             


Asn Gly Gln Val Thr Tyr Arg Leu Leu Glu Ala Glu Val Gly Arg Ala 
    530                 535                 540                 


Gly Gly Ala Val Ser Thr Tyr Val Ser Val Asp Pro Ala Thr Gly Ala 
545                 550                 555                 560 


Ile Tyr Ala Leu Arg Ser Phe Asp Tyr Glu Thr Leu Arg Gln Leu Asp 
                565                 570                 575     


Val Arg Ile Gln Ala Ser Asp Gly Gly Ser Pro Gln Leu Ser Ser Ser 
            580                 585                 590         


Ala Leu Val Gln Val Arg Val Leu Asp Gln Asn Asp His Ala Pro Val 
        595                 600                 605             


Leu Val His Pro Ala Pro Ala Asn Gly Ser Leu Glu Val Ala Val Pro 
    610                 615                 620                 


Gly Arg Thr Ala Lys Asp Thr Val Val Ala Arg Val Gln Ala Arg Asp 
625                 630                 635                 640 


Ala Asp Glu Gly Ala Asn Gly Glu Leu Ala Phe Glu Leu Gln Gln Gln 
                645                 650                 655     


Glu Pro Arg Glu Ala Phe Ala Ile Gly Arg Arg Thr Gly Glu Ile Leu 
            660                 665                 670         


Leu Thr Gly Asp Leu Ser Gln Glu Pro Pro Gly Arg Val Phe Arg Ala 
        675                 680                 685             


Leu Leu Val Ile Ser Asp Gly Gly Arg Pro Pro Leu Thr Thr Thr Ala 
    690                 695                 700                 


Thr Val Ser Phe Val Val Thr Ala Gly Gly Gly Arg Gly Pro Ala Ala 
705                 710                 715                 720 


Pro Ala Ser Ala Gly Ser Pro Glu Arg Ser Arg Pro Pro Gly Ser Arg 
                725                 730                 735     


Leu Gly Val Ser Gly Ser Val Leu Gln Trp Asp Thr Pro Leu Ile Val 
            740                 745                 750         


Ile Ile Val Leu Ala Gly Ser Cys Thr Leu Leu Leu Ala Ala Ile Ile 
        755                 760                 765             


Ala Ile Ala Thr Thr Cys Asn Arg Arg Lys Lys Glu Pro Tyr Gly Ala 
    770                 775                 780                 


Ser Pro Gly Phe Gly Lys Glu Pro Ala Pro Pro Val Ala Val Trp Lys 
785                 790                 795                 800 


Gly His Ser Phe Asn Thr Ile Ser Gly Arg Glu Ala Glu Lys Phe Ser 
                805                 810                 815     


Gly Lys Asp Ser Gly Lys Gly Asp Ser Asp Phe Asn Asp Ser Asp Ser 
            820                 825                 830         


Asp Ile Ser Gly Asp Ala Leu Lys Lys Asp Leu Ile Asn His Met Gln 
        835                 840                 845             


Ser Gly Leu Trp Ala Cys Thr Ala Glu Cys Lys Ile Leu Gly His Ser 
    850                 855                 860                 


Asp Arg Cys Trp Ser Pro Ser Cys Ser Gly Pro Asn Ala His Pro Ser 
865                 870                 875                 880 


Pro His Pro Pro Ala Gln Met Ser Thr Phe Cys Lys Ser Thr Ser Leu 
                885                 890                 895     


Pro Arg Asp Pro Leu Arg Arg Asp Asn Tyr Tyr Gln Ala Gln Leu Pro 
            900                 905                 910         


Lys Thr Val Gly Leu Gln Ser Val Tyr Glu Lys Val Leu His Arg Asp 
        915                 920                 925             


Tyr Asp Arg Thr Val Thr Leu Leu Ser Pro Pro Arg Pro Gly Arg Leu 
    930                 935                 940                 


Pro Asp Leu Gln Glu Ile Gly Val Pro Leu Tyr Gln Ser Pro Pro Gly 
945                 950                 955                 960 


Arg Tyr Leu Ser Pro Lys Lys Gly Ala Asn Glu Asn Val 
                965                 970             


<210>  5428
<211>  1040
<212>  PRT
<213>  Homo sapiens

<400>  5428

Met Ile Val Leu Leu Leu Phe Ala Leu Leu Trp Met Val Glu Gly Val 
1               5                   10                  15      


Phe Ser Gln Leu His Tyr Thr Val Gln Glu Glu Gln Glu His Gly Thr 
            20                  25                  30          


Phe Val Gly Asn Ile Ala Glu Asp Leu Gly Leu Asp Ile Thr Lys Leu 
        35                  40                  45              


Ser Ala Arg Gly Phe Gln Thr Val Pro Asn Ser Arg Thr Pro Tyr Leu 
    50                  55                  60                  


Asp Leu Asn Leu Glu Thr Gly Val Leu Tyr Val Asn Glu Lys Ile Asp 
65                  70                  75                  80  


Arg Glu Gln Ile Cys Lys Gln Ser Pro Ser Cys Val Leu His Leu Glu 
                85                  90                  95      


Val Phe Leu Glu Asn Pro Leu Glu Leu Phe Gln Val Glu Ile Glu Val 
            100                 105                 110         


Leu Asp Ile Asn Asp Asn Pro Pro Ser Phe Pro Glu Pro Asp Leu Thr 
        115                 120                 125             


Val Glu Ile Ser Glu Ser Ala Thr Pro Gly Thr Arg Phe Pro Leu Glu 
    130                 135                 140                 


Ser Ala Phe Asp Pro Asp Val Gly Thr Asn Ser Leu Arg Asp Tyr Glu 
145                 150                 155                 160 


Ile Thr Pro Asn Ser Tyr Phe Ser Leu Asp Val Gln Thr Gln Gly Asp 
                165                 170                 175     


Gly Asn Arg Phe Ala Glu Leu Val Leu Glu Lys Pro Leu Asp Arg Glu 
            180                 185                 190         


Gln Gln Ala Val His Arg Tyr Val Leu Thr Ala Val Asp Gly Gly Gly 
        195                 200                 205             


Gly Gly Gly Val Gly Glu Gly Gly Gly Gly Gly Gly Gly Ala Gly Leu 
    210                 215                 220                 


Pro Pro Gln Gln Gln Arg Thr Gly Thr Ala Leu Leu Thr Ile Arg Val 
225                 230                 235                 240 


Leu Asp Ser Asn Asp Asn Val Pro Ala Phe Asp Gln Pro Val Tyr Thr 
                245                 250                 255     


Val Ser Leu Pro Glu Asn Ser Pro Pro Gly Thr Leu Val Ile Gln Leu 
            260                 265                 270         


Asn Ala Thr Asp Pro Asp Glu Gly Gln Asn Gly Glu Val Val Tyr Ser 
        275                 280                 285             


Phe Ser Ser His Ile Ser Pro Arg Ala Arg Glu Leu Phe Gly Leu Ser 
    290                 295                 300                 


Pro Arg Thr Gly Arg Leu Glu Val Ser Gly Glu Leu Asp Tyr Glu Glu 
305                 310                 315                 320 


Ser Pro Val Tyr Gln Val Tyr Val Gln Ala Lys Asp Leu Gly Pro Asn 
                325                 330                 335     


Ala Val Pro Ala His Cys Lys Val Leu Val Arg Val Leu Asp Ala Asn 
            340                 345                 350         


Asp Asn Ala Pro Glu Ile Ser Phe Ser Thr Val Lys Glu Ala Val Ser 
        355                 360                 365             


Glu Gly Ala Ala Pro Gly Thr Val Val Ala Leu Phe Ser Val Thr Asp 
    370                 375                 380                 


Arg Asp Ser Glu Glu Asn Gly Gln Val Gln Cys Glu Leu Leu Gly Asp 
385                 390                 395                 400 


Val Pro Phe Arg Leu Lys Ser Ser Phe Lys Asn Tyr Tyr Thr Ile Val 
                405                 410                 415     


Thr Glu Ala Pro Leu Asp Arg Glu Ala Gly Asp Ser Tyr Thr Leu Thr 
            420                 425                 430         


Val Val Ala Arg Asp Arg Gly Glu Pro Ala Leu Ser Thr Ser Lys Ser 
        435                 440                 445             


Ile Gln Val Gln Val Ser Asp Val Asn Asp Asn Ala Pro Arg Phe Ser 
    450                 455                 460                 


Gln Pro Val Tyr Asp Val Tyr Val Thr Glu Asn Asn Val Pro Gly Ala 
465                 470                 475                 480 


Tyr Ile Tyr Ala Val Ser Ala Thr Asp Arg Asp Glu Gly Ala Asn Ala 
                485                 490                 495     


Gln Leu Ala Tyr Ser Ile Leu Glu Cys Gln Ile Gln Gly Met Ser Val 
            500                 505                 510         


Phe Thr Tyr Val Ser Ile Asn Ser Glu Asn Gly Tyr Leu Tyr Ala Leu 
        515                 520                 525             


Arg Ser Phe Asp Tyr Glu Gln Leu Lys Asp Phe Ser Phe Gln Val Glu 
    530                 535                 540                 


Ala Arg Asp Ala Gly Ser Pro Gln Ala Leu Ala Gly Asn Ala Thr Val 
545                 550                 555                 560 


Asn Ile Leu Ile Val Asp Gln Asn Asp Asn Ala Pro Ala Ile Val Ala 
                565                 570                 575     


Pro Leu Pro Gly Arg Asn Gly Thr Pro Ala Arg Glu Val Leu Pro Arg 
            580                 585                 590         


Ser Ala Glu Pro Gly Tyr Leu Leu Thr Arg Val Ala Ala Val Asp Ala 
        595                 600                 605             


Asp Asp Gly Glu Asn Ala Arg Leu Thr Tyr Ser Ile Val Arg Gly Asn 
    610                 615                 620                 


Glu Met Asn Leu Phe Arg Met Asp Trp Arg Thr Gly Glu Leu Arg Thr 
625                 630                 635                 640 


Ala Arg Arg Val Pro Ala Lys Arg Asp Pro Gln Arg Pro Tyr Glu Leu 
                645                 650                 655     


Val Ile Glu Val Arg Asp His Gly Gln Pro Pro Leu Ser Ser Thr Ala 
            660                 665                 670         


Thr Leu Val Val Gln Leu Val Asp Gly Ala Val Glu Pro Gln Gly Gly 
        675                 680                 685             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Glu His Gln Arg Pro Ser Arg 
    690                 695                 700                 


Ser Gly Gly Gly Glu Thr Ser Leu Asp Leu Thr Leu Ile Leu Ile Ile 
705                 710                 715                 720 


Ala Leu Gly Ser Val Ser Phe Ile Phe Leu Leu Ala Met Ile Val Leu 
                725                 730                 735     


Ala Val Arg Cys Gln Lys Glu Lys Lys Leu Asn Ile Tyr Thr Cys Leu 
            740                 745                 750         


Ala Ser Asp Cys Cys Leu Cys Cys Cys Cys Cys Gly Gly Gly Gly Ser 
        755                 760                 765             


Thr Cys Cys Gly Arg Gln Ala Arg Ala Arg Lys Lys Lys Leu Ser Lys 
    770                 775                 780                 


Ser Asp Ile Met Leu Val Gln Ser Ser Asn Val Pro Ser Asn Pro Ala 
785                 790                 795                 800 


Gln Val Pro Ile Glu Glu Ser Gly Gly Phe Gly Ser His His His Asn 
                805                 810                 815     


Gln Asn Tyr Cys Tyr Gln Val Cys Leu Thr Pro Glu Ser Ala Lys Thr 
            820                 825                 830         


Asp Leu Met Phe Leu Lys Pro Cys Ser Pro Ser Arg Ser Thr Asp Thr 
        835                 840                 845             


Glu His Asn Pro Cys Gly Ala Ile Val Thr Gly Tyr Thr Asp Gln Gln 
    850                 855                 860                 


Pro Asp Ile Ile Ser Asn Gly Ser Ile Leu Ser Asn Glu Thr Lys His 
865                 870                 875                 880 


Gln Arg Ala Glu Leu Ser Tyr Leu Val Asp Arg Pro Arg Arg Val Asn 
                885                 890                 895     


Ser Ser Ala Phe Gln Glu Ala Asp Ile Val Ser Ser Lys Asp Ser Gly 
            900                 905                 910         


His Gly Asp Ser Glu Gln Gly Asp Ser Asp His Asp Ala Thr Asn Arg 
        915                 920                 925             


Ala Gln Ser Ala Gly Met Asp Leu Phe Ser Asn Cys Thr Glu Glu Cys 
    930                 935                 940                 


Lys Ala Leu Gly His Ser Asp Arg Cys Trp Met Pro Ser Phe Val Pro 
945                 950                 955                 960 


Ser Asp Gly Arg Gln Ala Ala Asp Tyr Arg Ser Asn Leu His Val Pro 
                965                 970                 975     


Gly Met Asp Ser Val Pro Asp Thr Glu Val Phe Glu Thr Pro Glu Ala 
            980                 985                 990         


Gln Pro Gly Ala Glu Arg Ser Phe  Ser Thr Phe Gly Lys  Glu Lys Ala 
        995                 1000                 1005             


Leu His  Ser Thr Leu Glu Arg  Lys Glu Leu Asp Gly  Leu Leu Thr 
    1010                 1015                 1020             


Asn Thr  Arg Ala Pro Tyr Lys  Pro Pro Tyr Leu Thr  Arg Lys Arg 
    1025                 1030                 1035             


Ile Cys  
    1040 


<210>  5429
<211>  1347
<212>  PRT
<213>  Homo sapiens

<400>  5429

Met Asp Leu Leu Ser Gly Thr Tyr Ile Phe Ala Val Leu Leu Ala Cys 
1               5                   10                  15      


Val Val Phe His Ser Gly Ala Gln Glu Lys Asn Tyr Thr Ile Arg Glu 
            20                  25                  30          


Glu Met Pro Glu Asn Val Leu Ile Gly Asp Leu Leu Lys Asp Leu Asn 
        35                  40                  45              


Leu Ser Leu Ile Pro Asn Lys Ser Leu Thr Thr Ala Met Gln Phe Lys 
    50                  55                  60                  


Leu Val Tyr Lys Thr Gly Asp Val Pro Leu Ile Arg Ile Glu Glu Asp 
65                  70                  75                  80  


Thr Gly Glu Ile Phe Thr Thr Gly Ala Arg Ile Asp Arg Glu Lys Leu 
                85                  90                  95      


Cys Ala Gly Ile Pro Arg Asp Glu His Cys Phe Tyr Glu Val Glu Val 
            100                 105                 110         


Ala Ile Leu Pro Asp Glu Ile Phe Arg Leu Val Lys Ile Arg Phe Leu 
        115                 120                 125             


Ile Glu Asp Ile Asn Asp Asn Ala Pro Leu Phe Pro Ala Thr Val Ile 
    130                 135                 140                 


Asn Ile Ser Ile Pro Glu Asn Ser Ala Ile Asn Ser Lys Tyr Thr Leu 
145                 150                 155                 160 


Pro Ala Ala Val Asp Pro Asp Val Gly Ile Asn Gly Val Gln Asn Tyr 
                165                 170                 175     


Glu Leu Ile Lys Ser Gln Asn Ile Phe Gly Leu Asp Val Ile Glu Thr 
            180                 185                 190         


Pro Glu Gly Asp Lys Met Pro Gln Leu Ile Val Gln Lys Glu Leu Asp 
        195                 200                 205             


Arg Glu Glu Lys Asp Thr Tyr Val Met Lys Val Lys Val Glu Asp Gly 
    210                 215                 220                 


Gly Phe Pro Gln Arg Ser Ser Thr Ala Ile Leu Gln Val Ser Val Thr 
225                 230                 235                 240 


Asp Thr Asn Asp Asn His Pro Val Phe Lys Glu Thr Glu Ile Glu Val 
                245                 250                 255     


Ser Ile Pro Glu Asn Ala Pro Val Gly Thr Ser Val Thr Gln Leu His 
            260                 265                 270         


Ala Thr Asp Ala Asp Ile Gly Glu Asn Ala Lys Ile His Phe Ser Phe 
        275                 280                 285             


Ser Asn Leu Val Ser Asn Ile Ala Arg Arg Leu Phe His Leu Asn Ala 
    290                 295                 300                 


Thr Thr Gly Leu Ile Thr Ile Lys Glu Pro Leu Asp Arg Glu Glu Thr 
305                 310                 315                 320 


Pro Asn His Lys Leu Leu Val Leu Ala Ser Asp Gly Gly Leu Met Pro 
                325                 330                 335     


Ala Arg Ala Met Val Leu Val Asn Val Thr Asp Val Asn Asp Asn Val 
            340                 345                 350         


Pro Ser Ile Asp Ile Arg Tyr Ile Val Asn Pro Val Asn Asp Thr Val 
        355                 360                 365             


Val Leu Ser Glu Asn Ile Pro Leu Asn Thr Lys Ile Ala Leu Ile Thr 
    370                 375                 380                 


Val Thr Asp Lys Asp Ala Asp His Asn Gly Arg Val Thr Cys Phe Thr 
385                 390                 395                 400 


Asp His Glu Ile Pro Phe Arg Leu Arg Pro Val Phe Ser Asn Gln Phe 
                405                 410                 415     


Leu Leu Glu Thr Ala Ala Tyr Leu Asp Tyr Glu Ser Thr Lys Glu Tyr 
            420                 425                 430         


Ala Ile Lys Leu Leu Ala Ala Asp Ala Gly Lys Pro Pro Leu Asn Gln 
        435                 440                 445             


Ser Ala Met Leu Phe Ile Lys Val Lys Asp Glu Asn Asp Asn Ala Pro 
    450                 455                 460                 


Val Phe Thr Gln Ser Phe Val Thr Val Ser Ile Pro Glu Asn Asn Ser 
465                 470                 475                 480 


Pro Gly Ile Gln Leu Thr Lys Val Ser Ala Met Asp Ala Asp Ser Gly 
                485                 490                 495     


Pro Asn Ala Lys Ile Asn Tyr Leu Leu Gly Pro Asp Ala Pro Pro Glu 
            500                 505                 510         


Phe Ser Leu Asp Cys Arg Thr Gly Met Leu Thr Val Val Lys Lys Leu 
        515                 520                 525             


Asp Arg Glu Lys Glu Asp Lys Tyr Leu Phe Thr Ile Leu Ala Lys Asp 
    530                 535                 540                 


Asn Gly Val Pro Pro Leu Thr Ser Asn Val Thr Val Phe Val Ser Ile 
545                 550                 555                 560 


Ile Asp Gln Asn Asp Asn Ser Pro Val Phe Thr His Asn Glu Tyr Asn 
                565                 570                 575     


Phe Tyr Val Pro Glu Asn Leu Pro Arg His Gly Thr Val Gly Leu Ile 
            580                 585                 590         


Thr Val Thr Asp Pro Asp Tyr Gly Asp Asn Ser Ala Val Thr Leu Ser 
        595                 600                 605             


Ile Leu Asp Glu Asn Asp Asp Phe Thr Ile Asp Ser Gln Thr Gly Val 
    610                 615                 620                 


Ile Arg Pro Asn Ile Ser Phe Asp Arg Glu Lys Gln Glu Ser Tyr Thr 
625                 630                 635                 640 


Phe Tyr Val Lys Ala Glu Asp Gly Gly Arg Val Ser Arg Ser Ser Ser 
                645                 650                 655     


Ala Lys Val Thr Ile Asn Val Val Asp Val Asn Asp Asn Lys Pro Val 
            660                 665                 670         


Phe Ile Val Pro Pro Ser Asn Cys Ser Tyr Glu Leu Val Leu Pro Ser 
        675                 680                 685             


Thr Asn Pro Gly Thr Val Val Phe Gln Val Ile Ala Val Asp Asn Asp 
    690                 695                 700                 


Thr Gly Met Asn Ala Glu Val Arg Tyr Ser Ile Val Gly Gly Asn Thr 
705                 710                 715                 720 


Arg Asp Leu Phe Ala Ile Asp Gln Glu Thr Gly Asn Ile Thr Leu Met 
                725                 730                 735     


Glu Lys Cys Asp Val Thr Asp Leu Gly Leu His Arg Val Leu Val Lys 
            740                 745                 750         


Ala Asn Asp Leu Gly Gln Pro Asp Ser Leu Phe Ser Val Val Ile Val 
        755                 760                 765             


Asn Leu Phe Val Asn Glu Ser Val Thr Asn Ala Thr Leu Ile Asn Glu 
    770                 775                 780                 


Leu Val Arg Lys Ser Thr Glu Ala Pro Val Thr Pro Asn Thr Glu Ile 
785                 790                 795                 800 


Ala Asp Val Ser Ser Pro Thr Ser Asp Tyr Val Lys Ile Leu Val Ala 
                805                 810                 815     


Ala Val Ala Gly Thr Ile Thr Val Val Val Val Ile Phe Ile Thr Ala 
            820                 825                 830         


Val Val Arg Cys Arg Gln Ala Pro His Leu Lys Ala Ala Gln Lys Asn 
        835                 840                 845             


Lys Gln Asn Ser Glu Trp Ala Thr Pro Asn Pro Glu Asn Arg Gln Met 
    850                 855                 860                 


Ile Met Met Lys Lys Lys Lys Lys Lys Lys Lys His Ser Pro Lys Asn 
865                 870                 875                 880 


Leu Leu Leu Asn Phe Val Thr Ile Glu Glu Thr Lys Ala Asp Asp Val 
                885                 890                 895     


Asp Ser Asp Gly Asn Arg Val Thr Leu Asp Leu Pro Ile Asp Leu Glu 
            900                 905                 910         


Glu Gln Thr Met Gly Lys Tyr Asn Trp Val Thr Thr Pro Thr Thr Phe 
        915                 920                 925             


Lys Pro Asp Ser Pro Asp Leu Ala Arg His Tyr Lys Ser Ala Ser Pro 
    930                 935                 940                 


Gln Pro Ala Phe Gln Ile Gln Pro Glu Thr Pro Leu Asn Ser Lys His 
945                 950                 955                 960 


His Ile Ile Gln Glu Leu Pro Leu Asp Asn Thr Phe Val Ala Cys Asp 
                965                 970                 975     


Ser Ile Ser Lys Cys Ser Ser Ser Ser Ser Asp Pro Tyr Ser Val Ser 
            980                 985                 990         


Asp Cys Gly Tyr Pro Val Thr Thr  Phe Glu Val Pro Val  Ser Val His 
        995                 1000                 1005             


Thr Arg  Pro Pro Met Lys Glu  Val Val Arg Ser Cys  Thr Pro Met 
    1010                 1015                 1020             


Lys Glu  Ser Thr Thr Met Glu  Ile Trp Ile His Pro  Gln Pro Gln 
    1025                 1030                 1035             


Arg Lys  Ser Glu Gly Lys Val  Ala Gly Lys Ser Gln  Arg Arg Val 
    1040                 1045                 1050             


Thr Phe  His Leu Pro Glu Gly  Ser Gln Glu Ser Ser  Ser Asp Gly 
    1055                 1060                 1065             


Gly Leu  Gly Asp His Asp Ala  Gly Ser Leu Thr Ser  Thr Ser His 
    1070                 1075                 1080             


Gly Leu  Pro Leu Gly Tyr Pro  Gln Glu Glu Tyr Phe  Asp Arg Ala 
    1085                 1090                 1095             


Thr Pro  Ser Asn Arg Thr Glu  Gly Asp Gly Asn Ser  Asp Pro Glu 
    1100                 1105                 1110             


Ser Thr  Phe Ile Pro Gly Leu  Lys Lys Ala Ala Glu  Ile Thr Val 
    1115                 1120                 1125             


Gln Pro  Thr Val Glu Glu Ala  Ser Asp Asn Cys Thr  Gln Glu Cys 
    1130                 1135                 1140             


Leu Ile  Tyr Gly His Ser Asp  Ala Cys Trp Met Pro  Ala Ser Leu 
    1145                 1150                 1155             


Asp His  Ser Ser Ser Ser Gln  Ala Gln Ala Ser Ala  Leu Cys His 
    1160                 1165                 1170             


Ser Pro  Pro Leu Ser Gln Ala  Ser Thr Gln His His  Ser Pro Arg 
    1175                 1180                 1185             


Val Thr  Gln Thr Ile Ala Leu  Cys His Ser Pro Pro  Val Thr Gln 
    1190                 1195                 1200             


Thr Ile  Ala Leu Cys His Ser  Pro Pro Pro Ile Gln  Val Ser Ala 
    1205                 1210                 1215             


Leu His  His Ser Pro Pro Leu  Val Gln Ala Thr Ala  Leu His His 
    1220                 1225                 1230             


Ser Pro  Pro Ser Ala Gln Ala  Ser Ala Leu Cys Tyr  Ser Pro Pro 
    1235                 1240                 1245             


Leu Ala  Gln Ala Ala Ala Ile  Ser His Ser Ser Pro  Leu Pro Gln 
    1250                 1255                 1260             


Val Ile  Ala Leu His Arg Ser  Gln Ala Gln Ser Ser  Val Ser Leu 
    1265                 1270                 1275             


Gln Gln  Gly Trp Val Gln Gly  Ala Asp Gly Leu Cys  Ser Val Asp 
    1280                 1285                 1290             


Gln Gly  Val Gln Gly Ser Ala  Thr Ser Gln Phe Tyr  Thr Met Ser 
    1295                 1300                 1305             


Glu Arg  Leu His Pro Ser Asp  Asp Ser Ile Lys Val  Ile Pro Leu 
    1310                 1315                 1320             


Thr Thr  Phe Thr Pro Arg Gln  Gln Ala Arg Pro Ser  Arg Gly Asp 
    1325                 1330                 1335             


Ser Pro  Ile Met Glu Glu His  Pro Leu 
    1340                 1345         


<210>  5430
<211>  1347
<212>  PRT
<213>  Homo sapiens

<400>  5430

Met Asp Leu Leu Ser Gly Thr Tyr Ile Phe Ala Val Leu Leu Ala Cys 
1               5                   10                  15      


Val Val Phe His Ser Gly Ala Gln Glu Lys Asn Tyr Thr Ile Arg Glu 
            20                  25                  30          


Glu Met Pro Glu Asn Val Leu Ile Gly Asp Leu Leu Lys Asp Leu Asn 
        35                  40                  45              


Leu Ser Leu Ile Pro Asn Lys Ser Leu Thr Thr Ala Met Gln Phe Lys 
    50                  55                  60                  


Leu Val Tyr Lys Thr Gly Asp Val Pro Leu Ile Arg Ile Glu Glu Asp 
65                  70                  75                  80  


Thr Gly Glu Ile Phe Thr Thr Gly Ala Arg Ile Asp Arg Glu Lys Leu 
                85                  90                  95      


Cys Ala Gly Ile Pro Arg Asp Glu His Cys Phe Tyr Glu Val Glu Val 
            100                 105                 110         


Ala Ile Leu Pro Asp Glu Ile Phe Arg Leu Val Lys Ile Arg Phe Leu 
        115                 120                 125             


Ile Glu Asp Ile Asn Asp Asn Ala Pro Leu Phe Pro Ala Thr Val Ile 
    130                 135                 140                 


Asn Ile Ser Ile Pro Glu Asn Ser Ala Ile Asn Ser Lys Tyr Thr Leu 
145                 150                 155                 160 


Pro Ala Ala Val Asp Pro Asp Val Gly Ile Asn Gly Val Gln Asn Tyr 
                165                 170                 175     


Glu Leu Ile Lys Ser Gln Asn Ile Phe Gly Leu Asp Val Ile Glu Thr 
            180                 185                 190         


Pro Glu Gly Asp Lys Met Pro Gln Leu Ile Val Gln Lys Glu Leu Asp 
        195                 200                 205             


Arg Glu Glu Lys Asp Thr Tyr Val Met Lys Val Lys Val Glu Asp Gly 
    210                 215                 220                 


Gly Phe Pro Gln Arg Ser Ser Thr Ala Ile Leu Gln Val Ser Val Thr 
225                 230                 235                 240 


Asp Thr Asn Asp Asn His Pro Val Phe Lys Glu Thr Glu Ile Glu Val 
                245                 250                 255     


Ser Ile Pro Glu Asn Ala Pro Val Gly Thr Ser Val Thr Gln Leu His 
            260                 265                 270         


Ala Thr Asp Ala Asp Ile Gly Glu Asn Ala Lys Ile His Phe Ser Phe 
        275                 280                 285             


Ser Asn Leu Val Ser Asn Ile Ala Arg Arg Leu Phe His Leu Asn Ala 
    290                 295                 300                 


Thr Thr Gly Leu Ile Thr Ile Lys Glu Pro Leu Asp Arg Glu Glu Thr 
305                 310                 315                 320 


Pro Asn His Lys Leu Leu Val Leu Ala Ser Asp Gly Gly Leu Met Pro 
                325                 330                 335     


Ala Arg Ala Met Val Leu Val Asn Val Thr Asp Val Asn Asp Asn Val 
            340                 345                 350         


Pro Ser Ile Asp Ile Arg Tyr Ile Val Asn Pro Val Asn Asp Thr Val 
        355                 360                 365             


Val Leu Ser Glu Asn Ile Pro Leu Asn Thr Lys Ile Ala Leu Ile Thr 
    370                 375                 380                 


Val Thr Asp Lys Asp Ala Asp His Asn Gly Arg Val Thr Cys Phe Thr 
385                 390                 395                 400 


Asp His Glu Ile Pro Phe Arg Leu Arg Pro Val Phe Ser Asn Gln Phe 
                405                 410                 415     


Leu Leu Glu Thr Ala Ala Tyr Leu Asp Tyr Glu Ser Thr Lys Glu Tyr 
            420                 425                 430         


Ala Ile Lys Leu Leu Ala Ala Asp Ala Gly Lys Pro Pro Leu Asn Gln 
        435                 440                 445             


Ser Ala Met Leu Phe Ile Lys Val Lys Asp Glu Asn Asp Asn Ala Pro 
    450                 455                 460                 


Val Phe Thr Gln Ser Phe Val Thr Val Ser Ile Pro Glu Asn Asn Ser 
465                 470                 475                 480 


Pro Gly Ile Gln Leu Thr Lys Val Ser Ala Met Asp Ala Asp Ser Gly 
                485                 490                 495     


Pro Asn Ala Lys Ile Asn Tyr Leu Leu Gly Pro Asp Ala Pro Pro Glu 
            500                 505                 510         


Phe Ser Leu Asp Cys Arg Thr Gly Met Leu Thr Val Val Lys Lys Leu 
        515                 520                 525             


Asp Arg Glu Lys Glu Asp Lys Tyr Leu Phe Thr Ile Leu Ala Lys Asp 
    530                 535                 540                 


Asn Gly Val Pro Pro Leu Thr Ser Asn Val Thr Val Phe Val Ser Ile 
545                 550                 555                 560 


Ile Asp Gln Asn Asp Asn Ser Pro Val Phe Thr His Asn Glu Tyr Asn 
                565                 570                 575     


Phe Tyr Val Pro Glu Asn Leu Pro Arg His Gly Thr Val Gly Leu Ile 
            580                 585                 590         


Thr Val Thr Asp Pro Asp Tyr Gly Asp Asn Ser Ala Val Thr Leu Ser 
        595                 600                 605             


Ile Leu Asp Glu Asn Asp Asp Phe Thr Ile Asp Ser Gln Thr Gly Val 
    610                 615                 620                 


Ile Arg Pro Asn Ile Ser Phe Asp Arg Glu Lys Gln Glu Ser Tyr Thr 
625                 630                 635                 640 


Phe Tyr Val Lys Ala Glu Asp Gly Gly Arg Val Ser Arg Ser Ser Ser 
                645                 650                 655     


Ala Lys Val Thr Ile Asn Val Val Asp Val Asn Asp Asn Lys Pro Val 
            660                 665                 670         


Phe Ile Val Pro Pro Ser Asn Cys Ser Tyr Glu Leu Val Leu Pro Ser 
        675                 680                 685             


Thr Asn Pro Gly Thr Val Val Phe Gln Val Ile Ala Val Asp Asn Asp 
    690                 695                 700                 


Thr Gly Met Asn Ala Glu Val Arg Tyr Ser Ile Val Gly Gly Asn Thr 
705                 710                 715                 720 


Arg Asp Leu Phe Ala Ile Asp Gln Glu Thr Gly Asn Ile Thr Leu Met 
                725                 730                 735     


Glu Lys Cys Asp Val Thr Asp Leu Gly Leu His Arg Val Leu Val Lys 
            740                 745                 750         


Ala Asn Asp Leu Gly Gln Pro Asp Ser Leu Phe Ser Val Val Ile Val 
        755                 760                 765             


Asn Leu Phe Val Asn Glu Ser Val Thr Asn Ala Thr Leu Ile Asn Glu 
    770                 775                 780                 


Leu Val Arg Lys Ser Thr Glu Ala Pro Val Thr Pro Asn Thr Glu Ile 
785                 790                 795                 800 


Ala Asp Val Ser Ser Pro Thr Ser Asp Tyr Val Lys Ile Leu Val Ala 
                805                 810                 815     


Ala Val Ala Gly Thr Ile Thr Val Val Val Val Ile Phe Ile Thr Ala 
            820                 825                 830         


Val Val Arg Cys Arg Gln Ala Pro His Leu Lys Ala Ala Gln Lys Asn 
        835                 840                 845             


Lys Gln Asn Ser Glu Trp Ala Thr Pro Asn Pro Glu Asn Arg Gln Met 
    850                 855                 860                 


Ile Met Met Lys Lys Lys Lys Lys Lys Lys Lys His Ser Pro Lys Asn 
865                 870                 875                 880 


Leu Leu Leu Asn Phe Val Thr Ile Glu Glu Thr Lys Ala Asp Asp Val 
                885                 890                 895     


Asp Ser Asp Gly Asn Arg Val Thr Leu Asp Leu Pro Ile Asp Leu Glu 
            900                 905                 910         


Glu Gln Thr Met Gly Lys Tyr Asn Trp Val Thr Thr Pro Thr Thr Phe 
        915                 920                 925             


Lys Pro Asp Ser Pro Asp Leu Ala Arg His Tyr Lys Ser Ala Ser Pro 
    930                 935                 940                 


Gln Pro Ala Phe Gln Ile Gln Pro Glu Thr Pro Leu Asn Ser Lys His 
945                 950                 955                 960 


His Ile Ile Gln Glu Leu Pro Leu Asp Asn Thr Phe Val Ala Cys Asp 
                965                 970                 975     


Ser Ile Ser Lys Cys Ser Ser Ser Ser Ser Asp Pro Tyr Ser Val Ser 
            980                 985                 990         


Asp Cys Gly Tyr Pro Val Thr Thr  Phe Glu Val Pro Val  Ser Val His 
        995                 1000                 1005             


Thr Arg  Pro Pro Met Lys Glu  Val Val Arg Ser Cys  Thr Pro Met 
    1010                 1015                 1020             


Lys Glu  Ser Thr Thr Met Glu  Ile Trp Ile His Pro  Gln Pro Gln 
    1025                 1030                 1035             


Arg Lys  Ser Glu Gly Lys Val  Ala Gly Lys Ser Gln  Arg Arg Val 
    1040                 1045                 1050             


Thr Phe  His Leu Pro Glu Gly  Ser Gln Glu Ser Ser  Ser Asp Gly 
    1055                 1060                 1065             


Gly Leu  Gly Asp His Asp Ala  Gly Ser Leu Thr Ser  Thr Ser His 
    1070                 1075                 1080             


Gly Leu  Pro Leu Gly Tyr Pro  Gln Glu Glu Tyr Phe  Asp Arg Ala 
    1085                 1090                 1095             


Thr Pro  Ser Asn Arg Thr Glu  Gly Asp Gly Asn Ser  Asp Pro Glu 
    1100                 1105                 1110             


Ser Thr  Phe Ile Pro Gly Leu  Lys Lys Ala Ala Glu  Ile Thr Val 
    1115                 1120                 1125             


Gln Pro  Thr Val Glu Glu Ala  Ser Asp Asn Cys Thr  Gln Glu Cys 
    1130                 1135                 1140             


Leu Ile  Tyr Gly His Ser Asp  Ala Cys Trp Met Pro  Ala Ser Leu 
    1145                 1150                 1155             


Asp His  Ser Ser Ser Ser Gln  Ala Gln Ala Ser Ala  Leu Cys His 
    1160                 1165                 1170             


Ser Pro  Pro Leu Ser Gln Ala  Ser Thr Gln His His  Ser Pro Arg 
    1175                 1180                 1185             


Val Thr  Gln Thr Ile Ala Leu  Cys His Ser Pro Pro  Val Thr Gln 
    1190                 1195                 1200             


Thr Ile  Ala Leu Cys His Ser  Pro Pro Pro Ile Gln  Val Ser Ala 
    1205                 1210                 1215             


Leu His  His Ser Pro Pro Leu  Val Gln Ala Thr Ala  Leu His His 
    1220                 1225                 1230             


Ser Pro  Pro Ser Ala Gln Ala  Ser Ala Leu Cys Tyr  Ser Pro Pro 
    1235                 1240                 1245             


Leu Ala  Gln Ala Ala Ala Ile  Ser His Ser Ser Pro  Leu Pro Gln 
    1250                 1255                 1260             


Val Ile  Ala Leu His Arg Ser  Gln Ala Gln Ser Ser  Val Ser Leu 
    1265                 1270                 1275             


Gln Gln  Gly Trp Val Gln Gly  Ala Asp Gly Leu Cys  Ser Val Asp 
    1280                 1285                 1290             


Gln Gly  Val Gln Gly Ser Ala  Thr Ser Gln Phe Tyr  Thr Met Ser 
    1295                 1300                 1305             


Glu Arg  Leu His Pro Ser Asp  Asp Ser Ile Lys Val  Ile Pro Leu 
    1310                 1315                 1320             


Thr Thr  Phe Thr Pro Arg Gln  Gln Ala Arg Pro Ser  Arg Gly Asp 
    1325                 1330                 1335             


Ser Pro  Ile Met Glu Glu His  Pro Leu 
    1340                 1345         


<210>  5431
<211>  1337
<212>  PRT
<213>  Homo sapiens

<400>  5431

Met Asp Leu Leu Ser Gly Thr Tyr Ile Phe Ala Val Leu Leu Ala Cys 
1               5                   10                  15      


Val Val Phe His Ser Gly Ala Gln Glu Lys Asn Tyr Thr Ile Arg Glu 
            20                  25                  30          


Glu Met Pro Glu Asn Val Leu Ile Gly Asp Leu Leu Lys Asp Leu Asn 
        35                  40                  45              


Leu Ser Leu Ile Pro Asn Lys Ser Leu Thr Thr Ala Met Gln Phe Lys 
    50                  55                  60                  


Leu Val Tyr Lys Thr Gly Asp Val Pro Leu Ile Arg Ile Glu Glu Asp 
65                  70                  75                  80  


Thr Gly Glu Ile Phe Thr Thr Gly Ala Arg Ile Asp Arg Glu Lys Leu 
                85                  90                  95      


Cys Ala Gly Ile Pro Arg Asp Glu His Cys Phe Tyr Glu Val Glu Val 
            100                 105                 110         


Ala Ile Leu Pro Asp Glu Ile Phe Arg Leu Val Lys Ile Arg Phe Leu 
        115                 120                 125             


Ile Glu Asp Ile Asn Asp Asn Ala Pro Leu Phe Pro Ala Thr Val Ile 
    130                 135                 140                 


Asn Ile Ser Ile Pro Glu Asn Ser Ala Ile Asn Ser Lys Tyr Thr Leu 
145                 150                 155                 160 


Pro Ala Ala Val Asp Pro Asp Val Gly Ile Asn Gly Val Gln Asn Tyr 
                165                 170                 175     


Glu Leu Ile Lys Ser Gln Asn Ile Phe Gly Leu Asp Val Ile Glu Thr 
            180                 185                 190         


Pro Glu Gly Asp Lys Met Pro Gln Leu Ile Val Gln Lys Glu Leu Asp 
        195                 200                 205             


Arg Glu Glu Lys Asp Thr Tyr Val Met Lys Val Lys Val Glu Asp Gly 
    210                 215                 220                 


Gly Phe Pro Gln Arg Ser Ser Thr Ala Ile Leu Gln Val Ser Val Thr 
225                 230                 235                 240 


Asp Thr Asn Asp Asn His Pro Val Phe Lys Glu Thr Glu Ile Glu Val 
                245                 250                 255     


Ser Ile Pro Glu Asn Ala Pro Val Gly Thr Ser Val Thr Gln Leu His 
            260                 265                 270         


Ala Thr Asp Ala Asp Ile Gly Glu Asn Ala Lys Ile His Phe Ser Phe 
        275                 280                 285             


Ser Asn Leu Val Ser Asn Ile Ala Arg Arg Leu Phe His Leu Asn Ala 
    290                 295                 300                 


Thr Thr Gly Leu Ile Thr Ile Lys Glu Pro Leu Asp Arg Glu Glu Thr 
305                 310                 315                 320 


Pro Asn His Lys Leu Leu Val Leu Ala Ser Asp Gly Gly Leu Met Pro 
                325                 330                 335     


Ala Arg Ala Met Val Leu Val Asn Val Thr Asp Val Asn Asp Asn Val 
            340                 345                 350         


Pro Ser Ile Asp Ile Arg Tyr Ile Val Asn Pro Val Asn Asp Thr Val 
        355                 360                 365             


Val Leu Ser Glu Asn Ile Pro Leu Asn Thr Lys Ile Ala Leu Ile Thr 
    370                 375                 380                 


Val Thr Asp Lys Asp Ala Asp His Asn Gly Arg Val Thr Cys Phe Thr 
385                 390                 395                 400 


Asp His Glu Ile Pro Phe Arg Leu Arg Pro Val Phe Ser Asn Gln Phe 
                405                 410                 415     


Leu Leu Glu Thr Ala Ala Tyr Leu Asp Tyr Glu Ser Thr Lys Glu Tyr 
            420                 425                 430         


Ala Ile Lys Leu Leu Ala Ala Asp Ala Gly Lys Pro Pro Leu Asn Gln 
        435                 440                 445             


Ser Ala Met Leu Phe Ile Lys Val Lys Asp Glu Asn Asp Asn Ala Pro 
    450                 455                 460                 


Val Phe Thr Gln Ser Phe Val Thr Val Ser Ile Pro Glu Asn Asn Ser 
465                 470                 475                 480 


Pro Gly Ile Gln Leu Thr Lys Val Ser Ala Met Asp Ala Asp Ser Gly 
                485                 490                 495     


Pro Asn Ala Lys Ile Asn Tyr Leu Leu Gly Pro Asp Ala Pro Pro Glu 
            500                 505                 510         


Phe Ser Leu Asp Cys Arg Thr Gly Met Leu Thr Val Val Lys Lys Leu 
        515                 520                 525             


Asp Arg Glu Lys Glu Asp Lys Tyr Leu Phe Thr Ile Leu Ala Lys Asp 
    530                 535                 540                 


Asn Gly Val Pro Pro Leu Thr Ser Asn Val Thr Val Phe Val Ser Ile 
545                 550                 555                 560 


Ile Asp Gln Asn Asp Asn Ser Pro Val Phe Thr His Asn Glu Tyr Asn 
                565                 570                 575     


Phe Tyr Val Pro Glu Asn Leu Pro Arg His Gly Thr Val Gly Leu Ile 
            580                 585                 590         


Thr Val Thr Asp Pro Asp Tyr Gly Asp Asn Ser Ala Val Thr Leu Ser 
        595                 600                 605             


Ile Leu Asp Glu Asn Asp Asp Phe Thr Ile Asp Ser Gln Thr Gly Val 
    610                 615                 620                 


Ile Arg Pro Asn Ile Ser Phe Asp Arg Glu Lys Gln Glu Ser Tyr Thr 
625                 630                 635                 640 


Phe Tyr Val Lys Ala Glu Asp Gly Gly Arg Val Ser Arg Ser Ser Ser 
                645                 650                 655     


Ala Lys Val Thr Ile Asn Val Val Asp Val Asn Asp Asn Lys Pro Val 
            660                 665                 670         


Phe Ile Val Pro Pro Ser Asn Cys Ser Tyr Glu Leu Val Leu Pro Ser 
        675                 680                 685             


Thr Asn Pro Gly Thr Val Val Phe Gln Val Ile Ala Val Asp Asn Asp 
    690                 695                 700                 


Thr Gly Met Asn Ala Glu Val Arg Tyr Ser Ile Val Gly Gly Asn Thr 
705                 710                 715                 720 


Arg Asp Leu Phe Ala Ile Asp Gln Glu Thr Gly Asn Ile Thr Leu Met 
                725                 730                 735     


Glu Lys Cys Asp Val Thr Asp Leu Gly Leu His Arg Val Leu Val Lys 
            740                 745                 750         


Ala Asn Asp Leu Gly Gln Pro Asp Ser Leu Phe Ser Val Val Ile Val 
        755                 760                 765             


Asn Leu Phe Val Asn Glu Ser Val Thr Asn Ala Thr Leu Ile Asn Glu 
    770                 775                 780                 


Leu Val Arg Lys Ser Thr Glu Ala Pro Val Thr Pro Asn Thr Glu Ile 
785                 790                 795                 800 


Ala Asp Val Ser Ser Pro Thr Ser Asp Tyr Val Lys Ile Leu Val Ala 
                805                 810                 815     


Ala Val Ala Gly Thr Ile Thr Val Val Val Val Ile Phe Ile Thr Ala 
            820                 825                 830         


Val Val Arg Cys Arg Gln Ala Pro His Leu Lys Ala Ala Gln Lys Asn 
        835                 840                 845             


Lys Gln Asn Ser Glu Trp Ala Thr Pro Asn Pro Glu Asn Arg Gln Met 
    850                 855                 860                 


Ile Met Met Lys Lys Lys Lys Lys Lys Lys Lys His Ser Pro Lys Asn 
865                 870                 875                 880 


Leu Leu Leu Asn Phe Val Thr Ile Glu Glu Thr Lys Ala Asp Asp Val 
                885                 890                 895     


Asp Ser Asp Gly Asn Arg Val Thr Leu Asp Leu Pro Ile Asp Leu Glu 
            900                 905                 910         


Glu Gln Thr Met Gly Lys Tyr Asn Trp Val Thr Thr Pro Thr Thr Phe 
        915                 920                 925             


Lys Pro Asp Ser Pro Asp Leu Ala Arg His Tyr Lys Ser Ala Ser Pro 
    930                 935                 940                 


Gln Pro Ala Phe Gln Ile Gln Pro Glu Thr Pro Leu Asn Ser Lys His 
945                 950                 955                 960 


His Ile Ile Gln Glu Leu Pro Leu Asp Asn Thr Phe Val Ala Cys Asp 
                965                 970                 975     


Ser Ile Ser Lys Cys Ser Ser Ser Ser Ser Asp Pro Tyr Ser Val Ser 
            980                 985                 990         


Asp Cys Gly Tyr Pro Val Thr Thr  Phe Glu Val Pro Val  Ser Val His 
        995                 1000                 1005             


Thr Arg  Pro Pro Met Lys Glu  Val Val Arg Ser Cys  Thr Pro Met 
    1010                 1015                 1020             


Lys Glu  Ser Thr Thr Met Glu  Ile Trp Ile His Pro  Gln Pro Gln 
    1025                 1030                 1035             


Ser Gln  Arg Arg Val Thr Phe  His Leu Pro Glu Gly  Ser Gln Glu 
    1040                 1045                 1050             


Ser Ser  Ser Asp Gly Gly Leu  Gly Asp His Asp Ala  Gly Ser Leu 
    1055                 1060                 1065             


Thr Ser  Thr Ser His Gly Leu  Pro Leu Gly Tyr Pro  Gln Glu Glu 
    1070                 1075                 1080             


Tyr Phe  Asp Arg Ala Thr Pro  Ser Asn Arg Thr Glu  Gly Asp Gly 
    1085                 1090                 1095             


Asn Ser  Asp Pro Glu Ser Thr  Phe Ile Pro Gly Leu  Lys Lys Ala 
    1100                 1105                 1110             


Ala Glu  Ile Thr Val Gln Pro  Thr Val Glu Glu Ala  Ser Asp Asn 
    1115                 1120                 1125             


Cys Thr  Gln Glu Cys Leu Ile  Tyr Gly His Ser Asp  Ala Cys Trp 
    1130                 1135                 1140             


Met Pro  Ala Ser Leu Asp His  Ser Ser Ser Ser Gln  Ala Gln Ala 
    1145                 1150                 1155             


Ser Ala  Leu Cys His Ser Pro  Pro Leu Ser Gln Ala  Ser Thr Gln 
    1160                 1165                 1170             


His His  Ser Pro Arg Val Thr  Gln Thr Ile Ala Leu  Cys His Ser 
    1175                 1180                 1185             


Pro Pro  Val Thr Gln Thr Ile  Ala Leu Cys His Ser  Pro Pro Pro 
    1190                 1195                 1200             


Ile Gln  Val Ser Ala Leu His  His Ser Pro Pro Leu  Val Gln Ala 
    1205                 1210                 1215             


Thr Ala  Leu His His Ser Pro  Pro Ser Ala Gln Ala  Ser Ala Leu 
    1220                 1225                 1230             


Cys Tyr  Ser Pro Pro Leu Ala  Gln Ala Ala Ala Ile  Ser His Ser 
    1235                 1240                 1245             


Ser Pro  Leu Pro Gln Val Ile  Ala Leu His Arg Ser  Gln Ala Gln 
    1250                 1255                 1260             


Ser Ser  Val Ser Leu Gln Gln  Gly Trp Val Gln Gly  Ala Asp Gly 
    1265                 1270                 1275             


Leu Cys  Ser Val Asp Gln Gly  Val Gln Gly Ser Ala  Thr Ser Gln 
    1280                 1285                 1290             


Phe Tyr  Thr Met Ser Glu Arg  Leu His Pro Ser Asp  Asp Ser Ile 
    1295                 1300                 1305             


Lys Val  Ile Pro Leu Thr Thr  Phe Thr Pro Arg Gln  Gln Ala Arg 
    1310                 1315                 1320             


Pro Ser  Arg Gly Asp Ser Pro  Ile Met Glu Glu His  Pro Leu 
    1325                 1330                 1335         


<210>  5432
<211>  686
<212>  PRT
<213>  Homo sapiens

<400>  5432

Met Ile Glu Asp Ser Gly Lys Arg Gly Asn Thr Met Ala Glu Arg Arg 
1               5                   10                  15      


Gln Leu Phe Ala Glu Met Arg Ala Gln Asp Leu Asp Arg Ile Arg Leu 
            20                  25                  30          


Ser Thr Tyr Arg Thr Ala Cys Lys Leu Arg Phe Val Gln Lys Lys Cys 
        35                  40                  45              


Asn Leu His Leu Val Asp Ile Trp Asn Val Ile Glu Ala Leu Arg Glu 
    50                  55                  60                  


Asn Ala Leu Asn Asn Leu Asp Pro Asn Thr Glu Leu Asn Val Ser Arg 
65                  70                  75                  80  


Leu Glu Ala Val Leu Ser Thr Ile Phe Tyr Gln Leu Asn Lys Arg Met 
                85                  90                  95      


Pro Thr Thr His Gln Ile His Val Glu Gln Ser Ile Ser Leu Leu Leu 
            100                 105                 110         


Asn Phe Leu Leu Ala Ala Phe Asp Pro Glu Gly His Gly Lys Ile Ser 
        115                 120                 125             


Val Phe Ala Val Lys Met Ala Leu Ala Thr Leu Cys Gly Gly Lys Ile 
    130                 135                 140                 


Met Asp Lys Leu Arg Tyr Ile Phe Ser Met Ile Ser Asp Ser Ser Gly 
145                 150                 155                 160 


Val Met Val Tyr Gly Arg Tyr Asp Gln Phe Leu Arg Glu Val Leu Lys 
                165                 170                 175     


Leu Pro Thr Ala Val Phe Glu Gly Pro Ser Phe Gly Tyr Thr Glu Gln 
            180                 185                 190         


Ser Ala Arg Ser Cys Phe Ser Gln Gln Lys Lys Val Thr Leu Asn Gly 
        195                 200                 205             


Phe Leu Asp Thr Leu Met Ser Asp Pro Pro Pro Gln Cys Leu Val Trp 
    210                 215                 220                 


Leu Pro Leu Leu His Arg Leu Ala Asn Val Glu Asn Val Phe His Pro 
225                 230                 235                 240 


Val Glu Cys Ser Tyr Cys His Ser Glu Ser Met Met Gly Phe Arg Tyr 
                245                 250                 255     


Arg Cys Gln Gln Cys His Asn Tyr Gln Leu Cys Gln Asp Cys Phe Trp 
            260                 265                 270         


Arg Gly His Ala Gly Gly Ser His Ser Asn Gln His Gln Met Lys Glu 
        275                 280                 285             


Tyr Thr Ser Trp Lys Ser Pro Ala Lys Lys Leu Thr Asn Ala Leu Ser 
    290                 295                 300                 


Lys Ser Leu Ser Cys Ala Ser Ser Arg Glu Pro Leu His Pro Met Phe 
305                 310                 315                 320 


Pro Asp Gln Pro Glu Lys Pro Leu Asn Leu Ala His Ile Val Asp Thr 
                325                 330                 335     


Trp Pro Pro Arg Pro Val Thr Ser Met Asn Asp Thr Leu Phe Ser His 
            340                 345                 350         


Ser Val Pro Ser Ser Gly Ser Pro Phe Ile Thr Arg Ser Met Leu Glu 
        355                 360                 365             


Ser Ser Asn Arg Leu Asp Glu Glu His Arg Leu Ile Ala Arg Tyr Ala 
    370                 375                 380                 


Ala Arg Leu Ala Ala Glu Ser Ser Ser Ser Gln Pro Pro Gln Gln Arg 
385                 390                 395                 400 


Ser Ala Pro Asp Ile Ser Phe Thr Ile Asp Ala Asn Lys Gln Gln Arg 
                405                 410                 415     


Gln Leu Ile Ala Glu Leu Glu Asn Lys Asn Arg Glu Ile Leu Gln Glu 
            420                 425                 430         


Ile Gln Arg Leu Arg Leu Glu His Glu Gln Ala Ser Gln Pro Thr Pro 
        435                 440                 445             


Glu Lys Ala Gln Gln Asn Pro Thr Leu Leu Ala Glu Leu Arg Leu Leu 
    450                 455                 460                 


Arg Gln Arg Lys Asp Glu Leu Glu Gln Arg Met Ser Ala Leu Gln Glu 
465                 470                 475                 480 


Ser Arg Arg Glu Leu Met Val Gln Leu Glu Gly Leu Met Lys Leu Leu 
                485                 490                 495     


Lys Thr Gln Gly Ala Gly Ser Pro Arg Ser Ser Pro Ser His Thr Ile 
            500                 505                 510         


Ser Arg Pro Ile Pro Met Pro Ile Arg Ser Ala Ser Ala Cys Ser Thr 
        515                 520                 525             


Pro Thr His Thr Pro Gln Asp Ser Leu Thr Gly Val Gly Gly Asp Val 
    530                 535                 540                 


Gln Glu Ala Phe Ala Gln Ser Ser Arg Arg Asn Leu Arg Asn Asp Leu 
545                 550                 555                 560 


Leu Val Ala Ala Asp Ser Ile Thr Asn Thr Met Ser Ser Leu Val Lys 
                565                 570                 575     


Glu Leu Asn Ser Glu Val Gly Ser Glu Thr Glu Ser Asn Val Asp Ser 
            580                 585                 590         


Glu Phe Ala Arg Thr Gln Phe Glu Asp Leu Val Pro Ser Pro Thr Ser 
        595                 600                 605             


Glu Lys Ala Phe Leu Ala Gln Ile His Ala Arg Lys Pro Gly Tyr Ile 
    610                 615                 620                 


His Ser Gly Ala Thr Thr Ser Thr Met Arg Gly Asp Met Val Thr Glu 
625                 630                 635                 640 


Asp Ala Asp Pro Tyr Val Gln Pro Glu Asp Glu Asn Tyr Glu Asn Asp 
                645                 650                 655     


Ser Val Arg Gln Leu Glu Asn Glu Leu Gln Met Glu Glu Tyr Leu Lys 
            660                 665                 670         


Gln Lys Leu Gln Asp Glu Ala Tyr Gln Val Ser Leu Gln Gly 
        675                 680                 685     


<210>  5433
<211>  567
<212>  PRT
<213>  Homo sapiens

<400>  5433

Met Ile Glu Asp Ser Gly Lys Arg Gly Asn Thr Met Ala Glu Arg Arg 
1               5                   10                  15      


Gln Leu Phe Ala Glu Met Arg Ala Gln Asp Leu Asp Arg Ile Arg Leu 
            20                  25                  30          


Ser Thr Tyr Arg Thr Ala Cys Lys Leu Arg Phe Val Gln Lys Lys Cys 
        35                  40                  45              


Asn Leu His Leu Val Asp Ile Trp Asn Val Ile Glu Ala Leu Arg Glu 
    50                  55                  60                  


Asn Ala Leu Asn Asn Leu Asp Pro Asn Thr Glu Leu Asn Val Ser Arg 
65                  70                  75                  80  


Leu Glu Ala Val Leu Ser Thr Ile Phe Tyr Gln Leu Asn Lys Arg Met 
                85                  90                  95      


Pro Thr Thr His Gln Ile His Val Glu Gln Ser Ile Ser Leu Leu Leu 
            100                 105                 110         


Asn Phe Leu Leu Ala Ala Phe Asp Pro Glu Gly His Gly Lys Ile Ser 
        115                 120                 125             


Val Phe Ala Val Lys Met Ala Leu Ala Thr Leu Cys Gly Gly Lys Ile 
    130                 135                 140                 


Met Asp Lys Leu Arg Tyr Ile Phe Ser Met Ile Ser Asp Ser Ser Gly 
145                 150                 155                 160 


Val Met Val Tyr Gly Arg Tyr Asp Gln Phe Leu Arg Glu Val Leu Lys 
                165                 170                 175     


Leu Pro Thr Ala Val Phe Glu Gly Pro Ser Phe Gly Tyr Thr Glu Gln 
            180                 185                 190         


Ser Ala Arg Ser Cys Phe Ser Gln Gln Lys Lys Val Thr Leu Asn Gly 
        195                 200                 205             


Phe Leu Asp Thr Leu Met Ser Asp Pro Pro Pro Gln Cys Leu Val Trp 
    210                 215                 220                 


Leu Pro Leu Leu His Arg Leu Ala Asn Val Glu Asn Val Phe His Pro 
225                 230                 235                 240 


Val Glu Cys Ser Tyr Cys His Ser Glu Ser Met Met Gly Phe Arg Tyr 
                245                 250                 255     


Arg Cys Gln Gln Cys His Asn Tyr Gln Leu Cys Gln Asp Cys Phe Trp 
            260                 265                 270         


Arg Gly His Ala Gly Gly Ser His Ser Asn Gln His Gln Met Lys Glu 
        275                 280                 285             


Tyr Thr Ser Trp Lys Ser Pro Ala Lys Lys Leu Thr Asn Ala Leu Ser 
    290                 295                 300                 


Lys Ser Leu Ser Cys Ala Ser Ser Arg Glu Pro Leu His Pro Met Phe 
305                 310                 315                 320 


Pro Asp Gln Pro Glu Lys Pro Leu Asn Leu Ala His Ile Val Pro Pro 
                325                 330                 335     


Arg Pro Val Thr Ser Met Asn Asp Thr Leu Phe Ser His Ser Val Pro 
            340                 345                 350         


Ser Ser Gly Ser Pro Phe Ile Thr Arg Ser Ser Pro Pro Lys Asp Ser 
        355                 360                 365             


Glu Val Glu Gln Asn Lys Leu Leu Ala Arg Ala Ala Pro Ala Phe Leu 
    370                 375                 380                 


Lys Gly Lys Gly Ile Gln Tyr Ser Leu Asn Val Ala Asp Arg Leu Ala 
385                 390                 395                 400 


Asp Glu His Val Leu Ile Gly Leu Tyr Val Asn Met Leu Arg Asn Asn 
                405                 410                 415     


Pro Ser Cys Met Leu Glu Ser Ser Asn Arg Leu Asp Glu Glu His Arg 
            420                 425                 430         


Leu Ile Ala Arg Tyr Ala Ala Arg Leu Ala Ala Glu Ser Ser Ser Ser 
        435                 440                 445             


Gln Pro Pro Gln Gln Arg Ser Ala Pro Asp Ile Ser Phe Thr Ile Asp 
    450                 455                 460                 


Ala Asn Lys Gln Gln Arg Gln Leu Ile Ala Glu Leu Glu Asn Lys Asn 
465                 470                 475                 480 


Arg Glu Ile Leu Gln Glu Ile Gln Arg Leu Arg Leu Glu His Glu Gln 
                485                 490                 495     


Ala Ser Gln Pro Thr Pro Glu Lys Ala Gln Gln Asn Pro Thr Leu Leu 
            500                 505                 510         


Ala Glu Leu Arg Leu Leu Arg Gln Arg Lys Asp Glu Leu Glu Gln Arg 
        515                 520                 525             


Met Ser Ala Leu Gln Glu Ser Arg Arg Glu Leu Met Val Gln Leu Glu 
    530                 535                 540                 


Gly Leu Met Lys Leu Leu Lys Glu Glu Glu Leu Lys Gln Gly Val Ser 
545                 550                 555                 560 


Tyr Val Pro Tyr Cys Arg Ser 
                565         


<210>  5434
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  5434

Met Ile Glu Asp Ser Gly Lys Arg Gly Asn Thr Met Ala Glu Arg Arg 
1               5                   10                  15      


Gln Leu Phe Ala Glu Met Arg Ala Gln Asp Leu Asp Arg Ile Arg Leu 
            20                  25                  30          


Ser Thr Tyr Arg Thr Ala Cys Lys Leu Arg Phe Val Gln Lys Lys Cys 
        35                  40                  45              


Asn Leu His Leu Val Asp Ile Trp Asn Val Ile Glu Ala Leu Arg Glu 
    50                  55                  60                  


Asn Ala Leu Asn Asn Leu Asp Pro Asn Thr Glu Leu Asn Val Ser Arg 
65                  70                  75                  80  


Leu Glu Ala Val Leu Ser Thr Ile Phe Tyr Gln Leu Asn Lys Arg Met 
                85                  90                  95      


Pro Thr Thr His Gln Ile His Val Glu Gln Ser Ile Ser Leu Leu Leu 
            100                 105                 110         


Asn Phe Leu Leu Ala Ala Phe Asp Pro Glu Gly His Gly Lys Ile Ser 
        115                 120                 125             


Val Phe Ala Val Lys Met Ala Leu Ala Thr Leu Cys Gly Gly Lys Ile 
    130                 135                 140                 


Met Asp Lys Leu Arg Tyr Ile Phe Ser Met Ile Ser Asp Ser Ser Gly 
145                 150                 155                 160 


Val Met Val Tyr Gly Arg Tyr Asp Gln Phe Leu Arg Glu Val Leu Lys 
                165                 170                 175     


Leu Pro Thr Ala Val Phe Glu Gly Pro Ser Phe Gly Tyr Thr Glu Gln 
            180                 185                 190         


Ser Ala Arg Ser Cys Phe Ser Gln Gln Lys Lys Val Thr Leu Asn Gly 
        195                 200                 205             


Phe Leu Asp Thr Leu Met Ser Asp Pro Pro Pro Gln Cys Leu Val Trp 
    210                 215                 220                 


Leu Pro Leu Leu His Arg Leu Ala Asn Val Glu Asn Val Phe His Pro 
225                 230                 235                 240 


Val Glu Cys Ser Tyr Cys His Ser Glu Ser Met Met Gly Phe Arg Tyr 
                245                 250                 255     


Arg Cys Gln Gln Cys His Asn Tyr Gln Leu Cys Gln Asp Cys Phe Trp 
            260                 265                 270         


Arg Gly His Ala Gly Gly Ser His Ser Asn Gln His Gln Met Lys Glu 
        275                 280                 285             


Tyr Thr Ser Trp Lys Ser Pro Ala Lys Lys Leu Thr Asn Ala Leu Ser 
    290                 295                 300                 


Lys Ser Leu Ser Cys Ala Ser Ser Arg Glu Pro Leu His Pro Met Phe 
305                 310                 315                 320 


Pro Asp Gln Pro Glu Lys Pro Leu Asn Leu Ala His Ile Val Asp Thr 
                325                 330                 335     


Trp Pro Pro Arg Pro Val Thr Ser Met Asn Asp Thr Leu Phe Ser His 
            340                 345                 350         


Ser Val Pro Ser Ser Gly Ser Pro Phe Ile Thr Arg Ser Met Leu Glu 
        355                 360                 365             


Ser Ser Asn Arg Leu Asp Glu Glu His Arg Leu Ile Ala Arg Tyr Ala 
    370                 375                 380                 


Ala Arg Leu Ala Ala Glu Ser Ser Ser Ser Gln Pro Pro Gln Gln Arg 
385                 390                 395                 400 


Ser Ala Pro Asp Ile Ser Phe Thr Ile Asp Ala Asn Lys Gln Gln Arg 
                405                 410                 415     


Gln Leu Ile Ala Glu Leu Glu Asn Lys Asn Arg Glu Ile Leu Gln Glu 
            420                 425                 430         


Ile Gln Arg Leu Arg Leu Glu His Glu Gln Ala Ser Gln Pro Thr Pro 
        435                 440                 445             


Glu Lys Ala Gln Gln Asn Pro Thr Leu Leu Ala Glu Leu Arg Leu Leu 
    450                 455                 460                 


Arg Gln Arg Lys Asp Glu Leu Glu Gln Arg Met Ser Ala Leu Gln Glu 
465                 470                 475                 480 


Ser Arg Arg Glu Leu Met Val Gln Leu Glu Gly Leu Met Lys Leu Leu 
                485                 490                 495     


Lys Glu Glu Glu Leu Lys Gln Gly Val Ser Tyr Val Pro Tyr Cys Arg 
            500                 505                 510         


Ser 
    


<210>  5435
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  5435

Met Phe Pro Asp Gln Pro Glu Lys Pro Leu Asn Leu Ala His Ile Val 
1               5                   10                  15      


Pro Pro Arg Pro Val Thr Ser Met Asn Asp Thr Leu Phe Ser His Ser 
            20                  25                  30          


Val Pro Ser Ser Gly Ser Pro Phe Ile Thr Arg Ser Ser Pro Pro Lys 
        35                  40                  45              


Asp Ser Glu Val Glu Gln Asn Lys Leu Leu Ala Arg Ala Ala Pro Ala 
    50                  55                  60                  


Phe Leu Lys Gly Lys Gly Met Leu Glu Ser Ser Asn Arg Leu Asp Glu 
65                  70                  75                  80  


Glu His Arg Leu Ile Ala Arg Tyr Ala Ala Arg Leu Ala Ala Glu Ser 
                85                  90                  95      


Ser Ser Ser Gln Pro Pro Gln Gln Arg Ser Ala Pro Asp Ile Ser Phe 
            100                 105                 110         


Thr Ile Asp Ala Asn Lys Gln Gln Arg Gln Leu Ile Ala Glu Leu Glu 
        115                 120                 125             


Asn Lys Asn Arg Glu Ile Leu Gln Glu Ile Gln Arg Leu Arg Leu Glu 
    130                 135                 140                 


His Glu Gln Ala Ser Gln Pro Thr Pro Glu Lys Ala Gln Gln Asn Pro 
145                 150                 155                 160 


Thr Leu Leu Ala Glu Leu Arg Leu Leu Arg Gln Arg Lys Asp Glu Leu 
                165                 170                 175     


Glu Gln Arg Met Ser Ala Leu Gln Glu Ser Arg Arg Glu Leu Met Val 
            180                 185                 190         


Gln Leu Glu Gly Leu Met Lys Leu Leu Lys Thr Gln Gly Ala Gly Ser 
        195                 200                 205             


Pro Arg Ser Ser Pro Ser His Thr Ile Ser Arg Pro Ile Pro Met Pro 
    210                 215                 220                 


Ile Arg Ser Ala Ser Ala Cys Ser Thr Pro Thr His Thr Pro Gln Asp 
225                 230                 235                 240 


Ser Leu Thr Gly Val Gly Gly Asp Val Gln Glu Ala Phe Ala Gln Ser 
                245                 250                 255     


Ser Arg Arg Asn Leu Arg Asn Asp Leu Leu Val Ala Ala Asp Ser Ile 
            260                 265                 270         


Thr Asn Thr Met Ser Ser Leu Val Lys Glu Leu Asn Ser Glu Val Gly 
        275                 280                 285             


Ser Glu Thr Glu Ser Asn Val Asp Ser Glu Phe Ala Arg Thr Gln Phe 
    290                 295                 300                 


Glu Asp Leu Val Pro Ser Pro Thr Ser Glu Lys Ala Phe Leu Ala Gln 
305                 310                 315                 320 


Ile His Ala Arg Lys Pro Gly Tyr Ile His Ser Gly Ala Thr Thr Ser 
                325                 330                 335     


Thr Met Arg Gly Asp Met Val Thr Glu Asp Ala Asp Pro Tyr Val Gln 
            340                 345                 350         


Pro Glu Asp Glu Asn Tyr Glu Asn Asp Ser Val Arg Gln Leu Glu Asn 
        355                 360                 365             


Glu Leu Gln Met Glu Glu Tyr Leu Lys Gln Lys Leu Gln Asp Glu Ala 
    370                 375                 380                 


Tyr Gln Val Ser Leu Gln Gly 
385                 390     


<210>  5436
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  5436

Met Phe Pro Asp Gln Pro Glu Lys Pro Leu Asn Leu Ala His Ile Val 
1               5                   10                  15      


Pro Pro Arg Pro Val Thr Ser Met Asn Asp Thr Leu Phe Ser His Ser 
            20                  25                  30          


Val Pro Ser Ser Gly Ser Pro Phe Ile Thr Arg Ser Met Leu Glu Ser 
        35                  40                  45              


Ser Asn Arg Leu Asp Glu Glu His Arg Leu Ile Ala Arg Tyr Ala Ala 
    50                  55                  60                  


Arg Leu Ala Ala Glu Ser Ser Ser Ser Gln Pro Pro Gln Gln Arg Ser 
65                  70                  75                  80  


Ala Pro Asp Ile Ser Phe Thr Ile Asp Ala Asn Lys Gln Gln Arg Gln 
                85                  90                  95      


Leu Ile Ala Glu Leu Glu Asn Lys Asn Arg Glu Ile Leu Gln Glu Ile 
            100                 105                 110         


Gln Arg Leu Arg Leu Glu His Glu Gln Ala Ser Gln Pro Thr Pro Glu 
        115                 120                 125             


Lys Ala Gln Gln Asn Pro Thr Leu Leu Ala Glu Leu Arg Leu Leu Arg 
    130                 135                 140                 


Gln Arg Lys Asp Glu Leu Glu Gln Arg Met Ser Ala Leu Gln Glu Ser 
145                 150                 155                 160 


Arg Arg Glu Leu Met Val Gln Leu Glu Gly Leu Met Lys Leu Leu Lys 
                165                 170                 175     


Glu Glu Glu Leu Lys Gln Gly Val Ser Tyr Val Pro Tyr Cys Arg Ser 
            180                 185                 190         


<210>  5437
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  5437

Met Asp Pro Asn Arg Ile Ser Glu Asp Gly Thr His Cys Ile Tyr Arg 
1               5                   10                  15      


Ile Leu Arg Leu His Glu Asn Ala Asp Phe Gln Asp Thr Thr Leu Glu 
            20                  25                  30          


Ser Gln Asp Thr Lys Leu Ile Pro Asp Ser Cys Arg Arg Ile Lys Gln 
        35                  40                  45              


Ala Phe Gln Gly Ala Val Gln Lys Glu Leu Gln His Ile Val Gly Ser 
    50                  55                  60                  


Gln His Ile Arg Ala Glu Lys Ala Met Val Asp Gly Ser Trp Leu Asp 
65                  70                  75                  80  


Leu Ala Lys Arg Ser Lys Leu Glu Ala Gln Pro Phe Ala His Leu Thr 
                85                  90                  95      


Ile Asn Ala Thr Asp Ile Pro Ser Gly Ser His Lys Val Ser Leu Ser 
            100                 105                 110         


Ser Trp Tyr His Asp Arg Gly Trp Ala Lys Ile Ser Asn Met Thr Phe 
        115                 120                 125             


Ser Asn Gly Lys Leu Ile Val Asn Gln Asp Gly Phe Tyr Tyr Leu Tyr 
    130                 135                 140                 


Ala Asn Ile Cys Phe Arg His His Glu Thr Ser Gly Asp Leu Ala Thr 
145                 150                 155                 160 


Glu Tyr Leu Gln Leu Met Val Tyr Val Thr Lys Thr Ser Ile Lys Ile 
                165                 170                 175     


Pro Ser Ser His Thr Leu Met Lys Gly Gly Ser Thr Lys Tyr Trp Ser 
            180                 185                 190         


Gly Asn Ser Glu Phe His Phe Tyr Ser Ile Asn Val Gly Gly Phe Phe 
        195                 200                 205             


Lys Leu Arg Ser Gly Glu Glu Ile Ser Ile Glu Val Ser Asn Pro Ser 
    210                 215                 220                 


Leu Leu Asp Pro Asp Gln Asp Ala Thr Tyr Phe Gly Ala Phe Lys Val 
225                 230                 235                 240 


Arg Asp Ile Asp 
                


<210>  5438
<211>  5142
<212>  PRT
<213>  Homo sapiens

<400>  5438

Met Gly Asn Glu Ala Ser Leu Glu Gly Glu Gly Leu Pro Glu Gly Leu 
1               5                   10                  15      


Ala Ala Ala Ala Ala Ala Gly Gly Gly Ala Ser Gly Ala Gly Ser Pro 
            20                  25                  30          


Ser His Thr Ala Ile Pro Ala Gly Met Glu Ala Asp Leu Ser Gln Leu 
        35                  40                  45              


Ser Glu Glu Glu Arg Arg Gln Ile Ala Ala Val Met Ser Arg Ala Gln 
    50                  55                  60                  


Gly Leu Pro Lys Gly Ser Val Pro Pro Ala Ala Ala Glu Ser Pro Ser 
65                  70                  75                  80  


Met His Arg Lys Gln Glu Leu Asp Ser Ser His Pro Pro Lys Gln Ser 
                85                  90                  95      


Gly Arg Pro Pro Asp Pro Gly Arg Pro Ala Gln Pro Gly Leu Ser Lys 
            100                 105                 110         


Ser Arg Thr Thr Asp Thr Phe Arg Ser Glu Gln Lys Leu Pro Gly Arg 
        115                 120                 125             


Ser Pro Ser Thr Ile Ser Leu Lys Glu Ser Lys Ser Arg Thr Asp Leu 
    130                 135                 140                 


Lys Glu Glu His Lys Ser Ser Met Met Pro Gly Phe Leu Ser Glu Val 
145                 150                 155                 160 


Asn Ala Leu Ser Ala Val Ser Ser Val Val Asn Lys Phe Asn Pro Phe 
                165                 170                 175     


Asp Leu Ile Ser Asp Ser Glu Ala Ser Gln Glu Glu Thr Thr Lys Lys 
            180                 185                 190         


Gln Lys Val Val Gln Lys Glu Gln Gly Lys Pro Glu Gly Ile Ile Lys 
        195                 200                 205             


Pro Pro Leu Gln Gln Gln Pro Pro Lys Pro Ile Pro Lys Gln Gln Gly 
    210                 215                 220                 


Pro Gly Arg Asp Pro Leu Gln Gln Asp Gly Thr Pro Lys Ser Ile Ser 
225                 230                 235                 240 


Ser Gln Gln Pro Glu Lys Ile Lys Ser Gln Pro Pro Gly Thr Gly Lys 
                245                 250                 255     


Pro Ile Gln Gly Pro Thr Gln Thr Pro Gln Thr Asp His Ala Lys Leu 
            260                 265                 270         


Pro Leu Gln Arg Asp Ala Ser Arg Pro Gln Thr Lys Gln Ala Asp Ile 
        275                 280                 285             


Val Arg Gly Glu Ser Val Lys Pro Ser Leu Pro Ser Pro Ser Lys Pro 
    290                 295                 300                 


Pro Ile Gln Gln Pro Thr Pro Gly Lys Pro Pro Ala Gln Gln Pro Gly 
305                 310                 315                 320 


His Glu Lys Ser Gln Pro Gly Pro Ala Lys Pro Pro Ala Gln Pro Ser 
                325                 330                 335     


Gly Leu Thr Lys Pro Leu Ala Gln Gln Pro Gly Thr Val Lys Pro Pro 
            340                 345                 350         


Val Gln Pro Pro Gly Thr Thr Lys Pro Pro Ala Gln Pro Leu Gly Pro 
        355                 360                 365             


Ala Lys Pro Pro Ala Gln Gln Thr Gly Ser Glu Lys Pro Ser Ser Glu 
    370                 375                 380                 


Gln Pro Gly Pro Lys Ala Leu Ala Gln Pro Pro Gly Val Gly Lys Thr 
385                 390                 395                 400 


Pro Ala Gln Gln Pro Gly Pro Ala Lys Pro Pro Thr Gln Gln Val Gly 
                405                 410                 415     


Thr Pro Lys Pro Leu Ala Gln Gln Pro Gly Leu Gln Ser Pro Ala Lys 
            420                 425                 430         


Ala Pro Gly Pro Thr Lys Thr Pro Val Gln Gln Pro Gly Pro Gly Lys 
        435                 440                 445             


Ile Pro Ala Gln Gln Ala Gly Pro Gly Lys Thr Ser Ala Gln Gln Thr 
    450                 455                 460                 


Gly Pro Thr Lys Pro Pro Ser Gln Leu Pro Gly Pro Ala Lys Pro Pro 
465                 470                 475                 480 


Pro Gln Gln Pro Gly Pro Ala Lys Pro Pro Pro Gln Gln Pro Gly Ser 
                485                 490                 495     


Ala Lys Pro Pro Ser Gln Gln Pro Gly Ser Thr Lys Pro Pro Pro Gln 
            500                 505                 510         


Gln Pro Gly Pro Ala Lys Pro Ser Pro Gln Gln Pro Gly Ser Thr Lys 
        515                 520                 525             


Pro Pro Ser Gln Gln Pro Gly Ser Ala Lys Pro Ser Ala Gln Gln Pro 
    530                 535                 540                 


Ser Pro Ala Lys Pro Ser Ala Gln Gln Ser Thr Lys Pro Val Ser Gln 
545                 550                 555                 560 


Thr Gly Ser Gly Lys Pro Leu Gln Pro Pro Thr Val Ser Pro Ser Ala 
                565                 570                 575     


Lys Gln Pro Pro Ser Gln Gly Leu Pro Lys Thr Ile Cys Pro Leu Cys 
            580                 585                 590         


Asn Thr Thr Glu Leu Leu Leu His Val Pro Glu Lys Ala Asn Phe Asn 
        595                 600                 605             


Thr Cys Thr Glu Cys Gln Thr Thr Val Cys Ser Leu Cys Gly Phe Asn 
    610                 615                 620                 


Pro Asn Pro His Leu Thr Glu Val Lys Glu Trp Leu Cys Leu Asn Cys 
625                 630                 635                 640 


Gln Met Lys Arg Ala Leu Gly Gly Asp Leu Ala Pro Val Pro Ser Ser 
                645                 650                 655     


Pro Gln Pro Lys Leu Lys Thr Ala Pro Val Thr Thr Thr Ser Ala Val 
            660                 665                 670         


Ser Lys Ser Ser Pro Gln Pro Gln Gln Thr Ser Pro Lys Lys Asp Ala 
        675                 680                 685             


Ala Pro Lys Gln Asp Leu Ser Lys Ala Pro Glu Pro Lys Lys Pro Pro 
    690                 695                 700                 


Pro Leu Val Lys Gln Pro Thr Leu His Gly Ser Pro Ser Ala Lys Ala 
705                 710                 715                 720 


Lys Gln Pro Pro Glu Ala Asp Ser Leu Ser Lys Pro Ala Pro Pro Lys 
                725                 730                 735     


Glu Pro Ser Val Pro Ser Glu Gln Asp Lys Ala Pro Val Ala Asp Asp 
            740                 745                 750         


Lys Pro Lys Gln Pro Lys Met Val Lys Pro Thr Thr Asp Leu Val Ser 
        755                 760                 765             


Ser Ser Ser Ala Thr Thr Lys Pro Asp Ile Pro Ser Ser Lys Val Gln 
    770                 775                 780                 


Ser Gln Ala Glu Glu Lys Thr Thr Pro Pro Leu Lys Thr Asp Ser Ala 
785                 790                 795                 800 


Lys Pro Ser Gln Ser Phe Pro Pro Thr Gly Glu Lys Val Ser Pro Phe 
                805                 810                 815     


Asp Ser Lys Ala Ile Pro Arg Pro Ala Ser Asp Ser Lys Ile Ile Ser 
            820                 825                 830         


His Pro Gly Pro Ser Ser Glu Ser Lys Gly Gln Lys Gln Val Asp Pro 
        835                 840                 845             


Val Gln Lys Lys Glu Glu Pro Lys Lys Ala Gln Thr Lys Met Ser Pro 
    850                 855                 860                 


Lys Pro Asp Ala Lys Pro Met Pro Lys Gly Ser Pro Thr Pro Pro Gly 
865                 870                 875                 880 


Pro Arg Pro Thr Ala Gly Gln Thr Val Pro Thr Pro Gln Gln Ser Pro 
                885                 890                 895     


Lys Pro Gln Glu Gln Ser Arg Arg Phe Ser Leu Asn Leu Gly Ser Ile 
            900                 905                 910         


Thr Asp Ala Pro Lys Ser Gln Pro Thr Thr Pro Gln Glu Thr Val Thr 
        915                 920                 925             


Gly Lys Leu Phe Gly Phe Gly Ala Ser Ile Phe Ser Gln Ala Ser Asn 
    930                 935                 940                 


Leu Ile Ser Thr Ala Gly Gln Pro Gly Pro His Ser Gln Ser Gly Pro 
945                 950                 955                 960 


Gly Ala Pro Met Lys Gln Ala Pro Ala Pro Ser Gln Pro Pro Thr Ser 
                965                 970                 975     


Gln Gly Pro Pro Lys Ser Thr Gly Gln Ala Pro Pro Ala Pro Ala Lys 
            980                 985                 990         


Ser Ile Pro Val Lys Lys Glu Thr  Lys Ala Pro Ala Ala  Glu Lys Leu 
        995                 1000                 1005             


Glu Pro  Lys Ala Glu Gln Ala  Pro Thr Val Lys Arg  Thr Glu Thr 
    1010                 1015                 1020             


Glu Lys  Lys Pro Pro Pro Ile  Lys Asp Ser Lys Ser  Leu Thr Ala 
    1025                 1030                 1035             


Glu Pro  Gln Lys Ala Val Leu  Pro Thr Lys Leu Glu  Lys Ser Pro 
    1040                 1045                 1050             


Lys Pro  Glu Ser Thr Cys Pro  Leu Cys Lys Thr Glu  Leu Asn Ile 
    1055                 1060                 1065             


Gly Ser  Lys Asp Pro Pro Asn  Phe Asn Thr Cys Thr  Glu Cys Lys 
    1070                 1075                 1080             


Asn Gln  Val Cys Asn Leu Cys  Gly Phe Asn Pro Thr  Pro His Leu 
    1085                 1090                 1095             


Thr Glu  Ile Gln Glu Trp Leu  Cys Leu Asn Cys Gln  Thr Gln Arg 
    1100                 1105                 1110             


Ala Ile  Ser Gly Gln Leu Gly  Asp Ile Arg Lys Met  Pro Pro Ala 
    1115                 1120                 1125             


Pro Ser  Gly Pro Lys Ala Ser  Pro Met Pro Val Pro  Thr Glu Ser 
    1130                 1135                 1140             


Ser Ser  Gln Lys Thr Ala Val  Pro Pro Gln Val Lys  Leu Val Lys 
    1145                 1150                 1155             


Lys Gln  Glu Gln Glu Val Lys  Thr Glu Ala Glu Lys  Val Ile Leu 
    1160                 1165                 1170             


Glu Lys  Val Lys Glu Thr Leu  Ser Met Glu Lys Ile  Pro Pro Met 
    1175                 1180                 1185             


Val Thr  Thr Asp Gln Lys Gln  Glu Glu Ser Lys Leu  Glu Lys Asp 
    1190                 1195                 1200             


Lys Ala  Ser Ala Leu Gln Glu  Lys Lys Pro Leu Pro  Glu Glu Lys 
    1205                 1210                 1215             


Lys Leu  Ile Pro Glu Glu Glu  Lys Ile Arg Ser Glu  Glu Lys Lys 
    1220                 1225                 1230             


Pro Leu  Leu Glu Glu Lys Lys  Pro Thr Pro Glu Asp  Lys Lys Leu 
    1235                 1240                 1245             


Leu Pro  Glu Ala Lys Thr Ser  Ala Pro Glu Glu Gln  Lys His Asp 
    1250                 1255                 1260             


Leu Leu  Lys Ser Gln Val Gln  Ile Ala Glu Glu Lys  Leu Glu Gly 
    1265                 1270                 1275             


Arg Val  Ala Pro Lys Thr Val  Gln Glu Gly Lys Gln  Pro Gln Thr 
    1280                 1285                 1290             


Lys Met  Glu Gly Leu Pro Ser  Gly Thr Pro Gln Ser  Leu Pro Lys 
    1295                 1300                 1305             


Glu Asp  Asp Lys Thr Thr Lys  Thr Ile Lys Glu Gln  Pro Gln Pro 
    1310                 1315                 1320             


Pro Cys  Thr Ala Lys Pro Asp  Gln Val Glu Pro Gly  Lys Glu Lys 
    1325                 1330                 1335             


Thr Glu  Lys Glu Asp Asp Lys  Ser Asp Thr Ser Ser  Ser Gln Gln 
    1340                 1345                 1350             


Pro Lys  Ser Pro Gln Gly Leu  Ser Asp Thr Gly Tyr  Ser Ser Asp 
    1355                 1360                 1365             


Gly Ile  Ser Ser Ser Leu Gly  Glu Ile Pro Ser Leu  Ile Pro Thr 
    1370                 1375                 1380             


Asp Glu  Lys Asp Ile Leu Lys  Gly Leu Lys Lys Asp  Ser Phe Ser 
    1385                 1390                 1395             


Gln Glu  Ser Ser Pro Ser Ser  Pro Ser Asp Leu Ala  Lys Leu Glu 
    1400                 1405                 1410             


Ser Thr  Val Leu Ser Ile Leu  Glu Ala Gln Ala Ser  Thr Leu Ala 
    1415                 1420                 1425             


Asp Glu  Lys Ser Glu Lys Lys  Thr Gln Pro His Glu  Val Ser Pro 
    1430                 1435                 1440             


Glu Gln  Pro Lys Asp Gln Glu  Lys Thr Gln Ser Leu  Ser Glu Thr 
    1445                 1450                 1455             


Leu Glu  Ile Thr Ile Ser Glu  Glu Glu Ile Lys Glu  Ser Gln Glu 
    1460                 1465                 1470             


Glu Arg  Lys Asp Thr Phe Lys  Lys Asp Ser Gln Gln  Asp Ile Pro 
    1475                 1480                 1485             


Ser Ser  Lys Asp His Lys Glu  Lys Ser Glu Phe Val  Asp Asp Ile 
    1490                 1495                 1500             


Thr Thr  Arg Arg Glu Pro Tyr  Asp Ser Val Glu Glu  Ser Ser Glu 
    1505                 1510                 1515             


Ser Glu  Asn Ser Pro Val Pro  Gln Arg Lys Arg Arg  Thr Ser Val 
    1520                 1525                 1530             


Gly Ser  Ser Ser Ser Asp Glu  Tyr Lys Gln Glu Asp  Ser Gln Gly 
    1535                 1540                 1545             


Ser Gly  Glu Glu Glu Asp Phe  Ile Arg Lys Gln Ile  Ile Glu Met 
    1550                 1555                 1560             


Ser Ala  Asp Glu Asp Ala Ser  Gly Ser Glu Asp Asp  Glu Phe Ile 
    1565                 1570                 1575             


Arg Asn  Gln Leu Lys Glu Ile  Ser Ser Ser Thr Glu  Ser Gln Lys 
    1580                 1585                 1590             


Lys Glu  Glu Thr Lys Gly Lys  Gly Lys Ile Thr Ala  Gly Lys His 
    1595                 1600                 1605             


Arg Arg  Leu Thr Arg Lys Ser  Ser Thr Ser Ile Asp  Glu Asp Ala 
    1610                 1615                 1620             


Gly Arg  Arg His Ser Trp His  Asp Glu Asp Asp Glu  Ala Phe Asp 
    1625                 1630                 1635             


Glu Ser  Pro Glu Leu Lys Tyr  Arg Glu Thr Lys Ser  Gln Glu Ser 
    1640                 1645                 1650             


Glu Glu  Leu Val Val Thr Gly  Gly Gly Gly Leu Arg  Arg Phe Lys 
    1655                 1660                 1665             


Thr Ile  Glu Leu Asn Ser Thr  Ile Ala Asp Lys Tyr  Ser Ala Glu 
    1670                 1675                 1680             


Ser Ser  Gln Lys Lys Thr Ser  Leu Tyr Phe Asp Glu  Glu Pro Glu 
    1685                 1690                 1695             


Leu Glu  Met Glu Ser Leu Thr  Asp Ser Pro Glu Asp  Arg Ser Arg 
    1700                 1705                 1710             


Gly Glu  Gly Ser Ser Ser Leu  His Ala Ser Ser Phe  Thr Pro Gly 
    1715                 1720                 1725             


Thr Ser  Pro Thr Ser Val Ser  Ser Leu Asp Glu Asp  Ser Asp Ser 
    1730                 1735                 1740             


Ser Pro  Ser His Lys Lys Gly  Glu Ser Lys Gln Gln  Arg Lys Ala 
    1745                 1750                 1755             


Arg His  Arg Pro His Gly Pro  Leu Leu Pro Thr Ile  Glu Asp Ser 
    1760                 1765                 1770             


Ser Glu  Glu Glu Glu Leu Arg  Glu Glu Glu Glu Leu  Leu Lys Glu 
    1775                 1780                 1785             


Gln Glu  Lys Gln Arg Glu Ile  Glu Gln Gln Gln Arg  Lys Ser Ser 
    1790                 1795                 1800             


Ser Lys  Lys Ser Lys Lys Asp  Lys Asp Glu Leu Arg  Ala Gln Arg 
    1805                 1810                 1815             


Arg Arg  Glu Arg Pro Lys Thr  Pro Pro Ser Asn Leu  Ser Pro Ile 
    1820                 1825                 1830             


Glu Asp  Ala Ser Pro Thr Glu  Glu Leu Arg Gln Ala  Ala Glu Met 
    1835                 1840                 1845             


Glu Glu  Leu His Arg Ser Ser  Cys Ser Glu Tyr Ser  Pro Ser Ile 
    1850                 1855                 1860             


Glu Ser  Asp Pro Glu Gly Phe  Glu Ile Ser Pro Glu  Lys Ile Ile 
    1865                 1870                 1875             


Glu Val  Gln Lys Val Tyr Lys  Leu Pro Thr Ala Val  Ser Leu Tyr 
    1880                 1885                 1890             


Ser Pro  Thr Asp Glu Gln Ser  Ile Met Gln Lys Glu  Gly Ser Gln 
    1895                 1900                 1905             


Lys Ala  Leu Lys Ser Ala Glu  Glu Met Tyr Glu Glu  Met Met His 
    1910                 1915                 1920             


Lys Thr  His Lys Tyr Lys Ala  Phe Pro Ala Ala Asn  Glu Arg Asp 
    1925                 1930                 1935             


Glu Val  Phe Glu Lys Glu Pro  Leu Tyr Gly Gly Met  Leu Ile Glu 
    1940                 1945                 1950             


Asp Tyr  Ile Tyr Glu Ser Leu  Val Glu Asp Thr Tyr  Asn Gly Ser 
    1955                 1960                 1965             


Val Asp  Gly Ser Leu Leu Thr  Arg Gln Glu Glu Glu  Asn Gly Phe 
    1970                 1975                 1980             


Met Gln  Gln Lys Gly Arg Glu  Gln Lys Ile Arg Leu  Ser Glu Gln 
    1985                 1990                 1995             


Ile Tyr  Glu Asp Pro Met Gln  Lys Ile Thr Asp Leu  Gln Lys Glu 
    2000                 2005                 2010             


Phe Tyr  Glu Leu Glu Ser Leu  His Ser Val Val Pro  Gln Glu Asp 
    2015                 2020                 2025             


Ile Val  Ser Ser Ser Phe Ile  Ile Pro Glu Ser His  Glu Ile Val 
    2030                 2035                 2040             


Asp Leu  Gly Thr Met Val Thr  Ser Thr Glu Glu Glu  Arg Lys Leu 
    2045                 2050                 2055             


Leu Asp  Ala Asp Ala Ala Tyr  Glu Glu Leu Met Lys  Arg Gln Gln 
    2060                 2065                 2070             


Met Gln  Leu Thr Pro Gly Ser  Ser Pro Thr Gln Ala  Pro Ile Gly 
    2075                 2080                 2085             


Glu Asp  Met Thr Glu Ser Thr  Met Asp Phe Asp Arg  Met Pro Asp 
    2090                 2095                 2100             


Ala Ser  Leu Thr Ser Ser Val  Leu Ser Gly Ala Ser  Leu Thr Asp 
    2105                 2110                 2115             


Ser Thr  Ser Ser Ala Thr Leu  Ser Ile Pro Asp Val  Lys Ile Thr 
    2120                 2125                 2130             


Gln His  Phe Ser Thr Glu Glu  Ile Glu Asp Glu Tyr  Val Thr Asp 
    2135                 2140                 2145             


Tyr Thr  Arg Glu Ile Gln Glu  Ile Ile Ala His Glu  Ser Leu Ile 
    2150                 2155                 2160             


Leu Thr  Tyr Ser Glu Pro Ser  Glu Ser Ala Thr Ser  Val Pro Pro 
    2165                 2170                 2175             


Ser Asp  Thr Pro Ser Leu Thr  Ser Ser Val Ser Ser  Val Cys Thr 
    2180                 2185                 2190             


Thr Asp  Ser Ser Ser Pro Ile  Thr Thr Leu Asp Ser  Ile Thr Thr 
    2195                 2200                 2205             


Val Tyr  Thr Glu Pro Val Asp  Met Ile Thr Lys Phe  Glu Asp Ser 
    2210                 2215                 2220             


Glu Glu  Ile Ser Ser Ser Thr  Tyr Phe Pro Gly Ser  Ile Ile Asp 
    2225                 2230                 2235             


Tyr Pro  Glu Glu Ile Ser Val  Ser Leu Asp Arg Thr  Ala Pro Pro 
    2240                 2245                 2250             


Asp Gly  Arg Ala Ser Ala Asp  His Ile Val Ile Ser  Leu Ser Asp 
    2255                 2260                 2265             


Met Ala  Ser Ser Ile Ile Glu  Ser Val Val Pro Lys  Pro Glu Gly 
    2270                 2275                 2280             


Pro Val  Ala Asp Thr Val Ser  Thr Asp Leu Leu Ile  Ser Glu Lys 
    2285                 2290                 2295             


Asp Pro  Val Lys Lys Ala Lys  Lys Glu Thr Gly Asn  Gly Ile Ile 
    2300                 2305                 2310             


Leu Glu  Val Leu Glu Ala Tyr  Arg Asp Lys Lys Glu  Leu Glu Ala 
    2315                 2320                 2325             


Glu Arg  Thr Lys Ser Ser Leu  Ser Glu Thr Val Phe  Asp His Pro 
    2330                 2335                 2340             


Pro Ser  Ser Val Ile Ala Leu  Pro Met Lys Glu Gln  Leu Ser Thr 
    2345                 2350                 2355             


Thr Tyr  Phe Thr Ser Gly Glu  Thr Phe Gly Gln Glu  Lys Pro Ala 
    2360                 2365                 2370             


Ser Gln  Leu Pro Ser Gly Ser  Pro Ser Val Ser Ser  Leu Pro Ala 
    2375                 2380                 2385             


Lys Pro  Arg Pro Phe Phe Arg  Ser Ser Ser Leu Asp  Ile Ser Ala 
    2390                 2395                 2400             


Gln Pro  Pro Pro Pro Pro Pro  Pro Pro Pro Pro Pro  Pro Pro Pro 
    2405                 2410                 2415             


Pro Pro  Pro Pro Pro Pro Pro  Pro Leu Pro Pro Pro  Thr Ser Pro 
    2420                 2425                 2430             


Lys Pro  Thr Ile Leu Pro Lys  Lys Lys Leu Thr Val  Ala Ser Pro 
    2435                 2440                 2445             


Val Thr  Thr Ala Thr Pro Leu  Phe Asp Ala Val Thr  Thr Leu Glu 
    2450                 2455                 2460             


Thr Thr  Ala Val Leu Arg Ser  Asn Gly Leu Pro Val  Thr Arg Ile 
    2465                 2470                 2475             


Cys Thr  Thr Ala Pro Pro Pro  Val Pro Pro Lys Pro  Ser Ser Ile 
    2480                 2485                 2490             


Pro Ser  Gly Leu Val Phe Thr  His Arg Pro Glu Pro  Ser Lys Pro 
    2495                 2500                 2505             


Pro Ile  Ala Pro Lys Pro Val  Ile Pro Gln Leu Pro  Thr Thr Thr 
    2510                 2515                 2520             


Gln Lys  Pro Thr Asp Ile His  Pro Lys Pro Thr Gly  Leu Ser Leu 
    2525                 2530                 2535             


Thr Ser  Ser Met Thr Leu Asn  Leu Val Thr Ser Ala  Asp Tyr Lys 
    2540                 2545                 2550             


Leu Pro  Ser Pro Thr Ser Pro  Leu Ser Pro His Ser  Asn Lys Ser 
    2555                 2560                 2565             


Ser Pro  Arg Phe Ser Lys Ser  Leu Thr Glu Thr Tyr  Val Val Ile 
    2570                 2575                 2580             


Thr Leu  Pro Ser Glu Pro Gly  Thr Pro Thr Asp Ser  Ser Ala Ser 
    2585                 2590                 2595             


Gln Ala  Ile Thr Ser Trp Pro  Leu Gly Ser Pro Ser  Lys Asp Leu 
    2600                 2605                 2610             


Val Ser  Val Glu Pro Val Phe  Ser Val Val Pro Pro  Val Thr Ala 
    2615                 2620                 2625             


Val Glu  Ile Pro Ile Ser Ser  Glu Gln Thr Phe Tyr  Ile Ser Gly 
    2630                 2635                 2640             


Ala Leu  Gln Thr Phe Ser Ala  Thr Pro Val Thr Ala  Pro Ser Ser 
    2645                 2650                 2655             


Phe Gln  Ala Ala Pro Thr Ser  Val Thr Gln Phe Leu  Thr Thr Glu 
    2660                 2665                 2670             


Val Ser  Lys Thr Glu Val Ser  Ala Thr Arg Ser Thr  Ala Pro Ser 
    2675                 2680                 2685             


Val Gly  Leu Ser Ser Ile Ser  Ile Thr Ile Pro Pro  Glu Pro Leu 
    2690                 2695                 2700             


Ala Leu  Asp Asn Ile His Leu  Glu Lys Pro Gln Tyr  Lys Glu Asp 
    2705                 2710                 2715             


Gly Lys  Leu Gln Leu Val Gly  Asp Val Ile Asp Leu  Arg Thr Val 
    2720                 2725                 2730             


Pro Lys  Val Glu Val Lys Thr  Thr Asp Lys Cys Ile  Asp Leu Ser 
    2735                 2740                 2745             


Ala Ser  Thr Met Asp Val Lys  Arg Gln Ile Thr Ala  Asn Glu Val 
    2750                 2755                 2760             


Tyr Gly  Lys Gln Ile Ser Ala  Val Gln Pro Ser Ile  Ile Asn Leu 
    2765                 2770                 2775             


Ser Val  Thr Ser Ser Ile Val  Thr Pro Val Ser Leu  Ala Thr Glu 
    2780                 2785                 2790             


Thr Val  Thr Phe Val Thr Cys  Thr Ala Ser Ala Ser  Tyr Thr Thr 
    2795                 2800                 2805             


Gly Thr  Glu Ser Leu Val Gly  Ala Glu His Ala Met  Thr Thr Pro 
    2810                 2815                 2820             


Leu Gln  Leu Thr Thr Ser Lys  His Ala Glu Pro Pro  Tyr Arg Ile 
    2825                 2830                 2835             


Pro Ser  Asp Gln Val Phe Pro  Ile Ala Arg Glu Glu  Ala Pro Ile 
    2840                 2845                 2850             


Asn Leu  Ser Leu Gly Thr Pro  Ala His Ala Val Thr  Leu Ala Ile 
    2855                 2860                 2865             


Thr Lys  Pro Val Thr Val Pro  Pro Val Gly Val Thr  Asn Gly Trp 
    2870                 2875                 2880             


Thr Asp  Ser Thr Val Ser Gln  Gly Ile Thr Asp Gly  Glu Val Val 
    2885                 2890                 2895             


Asp Leu  Ser Thr Thr Lys Ser  His Arg Thr Val Val  Thr Met Asp 
    2900                 2905                 2910             


Glu Ser  Thr Ser Ser Val Met  Thr Lys Ile Ile Glu  Asp Glu Lys 
    2915                 2920                 2925             


Pro Val  Asp Leu Thr Ala Gly  Arg Arg Ala Val Cys  Cys Asp Val 
    2930                 2935                 2940             


Val Tyr  Lys Leu Pro Phe Gly  Arg Ser Cys Thr Ala  Gln Gln Pro 
    2945                 2950                 2955             


Ala Thr  Thr Leu Pro Glu Asp  Arg Phe Gly Tyr Arg  Asp Asp His 
    2960                 2965                 2970             


Tyr Gln  Tyr Asp Arg Ser Gly  Pro Tyr Gly Tyr Arg  Gly Ile Gly 
    2975                 2980                 2985             


Gly Met  Lys Pro Ser Met Ser  Asp Thr Asn Leu Ala  Glu Ala Gly 
    2990                 2995                 3000             


His Phe  Phe Tyr Lys Ser Lys  Asn Ala Phe Asp Tyr  Ser Glu Gly 
    3005                 3010                 3015             


Thr Asp  Thr Ala Val Asp Leu  Thr Ser Gly Arg Val  Thr Thr Gly 
    3020                 3025                 3030             


Glu Val  Met Asp Tyr Ser Ser  Lys Thr Thr Gly Pro  Tyr Pro Glu 
    3035                 3040                 3045             


Thr Arg  Gln Val Ile Ser Gly  Ala Gly Ile Ser Thr  Pro Gln Tyr 
    3050                 3055                 3060             


Ser Thr  Ala Arg Met Thr Pro  Pro Pro Gly Pro Gln  Tyr Cys Val 
    3065                 3070                 3075             


Gly Ser  Val Leu Arg Ser Ser  Asn Gly Val Val Tyr  Ser Ser Val 
    3080                 3085                 3090             


Ala Thr  Pro Thr Pro Ser Thr  Phe Ala Ile Thr Thr  Gln Pro Gly 
    3095                 3100                 3105             


Ser Ile  Phe Ser Thr Thr Val  Arg Asp Leu Ser Gly  Ile His Thr 
    3110                 3115                 3120             


Ala Asp  Ala Val Thr Ser Leu  Pro Ala Met His His  Ser Gln Pro 
    3125                 3130                 3135             


Met Pro  Arg Ser Tyr Phe Ile  Thr Thr Gly Ala Ser  Glu Thr Asp 
    3140                 3145                 3150             


Ile Ala  Val Thr Gly Ile Asp  Ile Ser Ala Ser Leu  Gln Thr Ile 
    3155                 3160                 3165             


Thr Met  Glu Ser Leu Thr Ala  Glu Thr Ile Asp Ser  Val Pro Thr 
    3170                 3175                 3180             


Leu Thr  Thr Ala Ser Glu Val  Phe Pro Glu Val Val  Gly Asp Glu 
    3185                 3190                 3195             


Ser Ala  Leu Leu Ile Val Pro  Glu Glu Asp Lys Gln  Gln Gln Gln 
    3200                 3205                 3210             


Leu Asp  Leu Glu Arg Glu Leu  Leu Glu Leu Glu Lys  Ile Lys Gln 
    3215                 3220                 3225             


Gln Arg  Phe Ala Glu Glu Leu  Glu Trp Glu Arg Gln  Glu Ile Gln 
    3230                 3235                 3240             


Arg Phe  Arg Glu Gln Glu Lys  Ile Met Val Gln Lys  Lys Leu Glu 
    3245                 3250                 3255             


Glu Leu  Gln Ser Met Lys Gln  His Leu Leu Phe Gln  Gln Glu Glu 
    3260                 3265                 3270             


Glu Arg  Gln Ala Gln Phe Met  Met Arg Gln Glu Thr  Leu Ala Gln 
    3275                 3280                 3285             


Gln Gln  Leu Gln Leu Glu Gln  Ile Gln Gln Leu Gln  Gln Gln Leu 
    3290                 3295                 3300             


His Gln  Gln Leu Glu Glu Gln  Lys Ile Arg Gln Ile  Tyr Gln Tyr 
    3305                 3310                 3315             


Asn Tyr  Asp Pro Ser Gly Thr  Ala Ser Pro Gln Thr  Thr Thr Glu 
    3320                 3325                 3330             


Gln Ala  Ile Leu Glu Gly Gln  Tyr Ala Ala Leu Glu  Gly Ser Gln 
    3335                 3340                 3345             


Phe Trp  Ala Thr Glu Asp Ala  Thr Thr Thr Ala Ser  Ala Val Val 
    3350                 3355                 3360             


Ala Ile  Glu Ile Pro Gln Ser  Gln Gly Trp Tyr Thr  Val Gln Ser 
    3365                 3370                 3375             


Asp Gly  Val Thr Gln Tyr Ile  Ala Pro Pro Gly Ile  Leu Ser Thr 
    3380                 3385                 3390             


Val Ser  Glu Ile Pro Leu Thr  Asp Val Val Val Lys  Glu Glu Lys 
    3395                 3400                 3405             


Gln Pro  Lys Lys Arg Ser Ser  Gly Ala Lys Val Arg  Gly Gln Tyr 
    3410                 3415                 3420             


Asp Asp  Met Gly Glu Asn Met  Thr Asp Asp Pro Arg  Ser Phe Lys 
    3425                 3430                 3435             


Lys Ile  Val Asp Ser Gly Val  Gln Thr Asp Asp Glu  Asp Ala Thr 
    3440                 3445                 3450             


Asp Arg  Ser Tyr Val Ser Arg  Arg Arg Arg Thr Lys  Lys Ser Val 
    3455                 3460                 3465             


Asp Thr  Ser Val Gln Thr Asp  Asp Glu Asp Gln Asp  Glu Trp Asp 
    3470                 3475                 3480             


Met Pro  Thr Arg Ser Arg Arg  Lys Ala Arg Val Gly  Lys Tyr Gly 
    3485                 3490                 3495             


Asp Ser  Met Thr Glu Ala Asp  Lys Thr Lys Pro Leu  Ser Lys Val 
    3500                 3505                 3510             


Ser Ser  Ile Ala Val Gln Thr  Val Ala Glu Ile Ser  Val Gln Thr 
    3515                 3520                 3525             


Glu Pro  Val Gly Thr Ile Arg  Thr Pro Ser Ile Arg  Ala Arg Val 
    3530                 3535                 3540             


Asp Ala  Lys Val Glu Ile Ile  Lys His Ile Ser Ala  Pro Glu Lys 
    3545                 3550                 3555             


Thr Tyr  Lys Gly Gly Ser Leu  Gly Cys Gln Thr Glu  Ala Asp Ser 
    3560                 3565                 3570             


Asp Thr  Gln Ser Pro Gln Tyr  Leu Ser Ala Thr Ser  Pro Pro Lys 
    3575                 3580                 3585             


Asp Lys  Lys Arg Pro Thr Pro  Leu Glu Ile Gly Tyr  Ser Ser His 
    3590                 3595                 3600             


Leu Arg  Ala Asp Ser Thr Val  Gln Leu Ala Pro Ser  Pro Pro Lys 
    3605                 3610                 3615             


Ser Pro  Lys Val Leu Tyr Ser  Pro Ile Ser Pro Leu  Ser Pro Gly 
    3620                 3625                 3630             


Lys Ala  Leu Glu Ser Ala Phe  Val Pro Tyr Glu Lys  Pro Leu Pro 
    3635                 3640                 3645             


Asp Asp  Ile Ser Pro Gln Lys  Val Leu His Pro Asp  Met Ala Lys 
    3650                 3655                 3660             


Val Pro  Pro Ala Ser Pro Lys  Thr Ala Lys Met Met  Gln Arg Ser 
    3665                 3670                 3675             


Met Ser  Asp Pro Lys Pro Leu  Ser Pro Thr Ala Asp  Glu Ser Ser 
    3680                 3685                 3690             


Arg Ala  Pro Phe Gln Tyr Thr  Glu Gly Tyr Thr Thr  Lys Gly Ser 
    3695                 3700                 3705             


Gln Thr  Met Thr Ser Ser Gly  Ala Gln Lys Lys Val  Lys Arg Thr 
    3710                 3715                 3720             


Leu Pro  Asn Pro Pro Pro Glu  Glu Ile Ser Thr Gly  Thr Gln Ser 
    3725                 3730                 3735             


Thr Phe  Ser Thr Met Gly Thr  Val Ser Arg Arg Arg  Ile Cys Arg 
    3740                 3745                 3750             


Thr Asn  Thr Met Ala Arg Ala  Lys Ile Leu Gln Asp  Ile Asp Arg 
    3755                 3760                 3765             


Glu Leu  Asp Leu Val Glu Arg  Glu Ser Ala Lys Leu  Arg Lys Lys 
    3770                 3775                 3780             


Gln Ala  Glu Leu Asp Glu Glu  Glu Lys Glu Ile Asp  Ala Lys Leu 
    3785                 3790                 3795             


Arg Tyr  Leu Glu Met Gly Ile  Asn Arg Arg Lys Glu  Ala Leu Leu 
    3800                 3805                 3810             


Lys Glu  Arg Glu Lys Arg Glu  Arg Ala Tyr Leu Gln  Gly Val Ala 
    3815                 3820                 3825             


Glu Asp  Arg Asp Tyr Met Ser  Asp Ser Glu Val Ser  Ser Thr Arg 
    3830                 3835                 3840             


Pro Thr  Arg Ile Glu Ser Gln  His Gly Ile Glu Arg  Pro Arg Thr 
    3845                 3850                 3855             


Ala Pro  Gln Thr Glu Phe Ser  Gln Phe Ile Pro Pro  Gln Thr Gln 
    3860                 3865                 3870             


Thr Glu  Ser Gln Leu Val Pro  Pro Thr Ser Pro Tyr  Thr Gln Tyr 
    3875                 3880                 3885             


Gln Tyr  Ser Ser Pro Ala Leu  Pro Thr Gln Ala Pro  Thr Ser Tyr 
    3890                 3895                 3900             


Thr Gln  Gln Ser His Phe Glu  Gln Gln Thr Leu Tyr  His Gln Gln 
    3905                 3910                 3915             


Val Ser  Pro Tyr Gln Thr Gln  Pro Thr Phe Gln Ala  Val Ala Thr 
    3920                 3925                 3930             


Met Ser  Phe Thr Pro Gln Val  Gln Pro Thr Pro Thr  Pro Gln Pro 
    3935                 3940                 3945             


Ser Tyr  Gln Leu Pro Ser Gln  Met Met Val Ile Gln  Gln Lys Pro 
    3950                 3955                 3960             


Arg Gln  Thr Thr Leu Tyr Leu  Glu Pro Lys Ile Thr  Ser Asn Tyr 
    3965                 3970                 3975             


Glu Val  Ile Arg Asn Gln Pro  Leu Met Ile Ala Pro  Val Ser Thr 
    3980                 3985                 3990             


Asp Asn  Thr Phe Ala Val Ser  His Leu Gly Ser Lys  Tyr Asn Ser 
    3995                 4000                 4005             


Leu Asp  Leu Arg Ile Gly Leu  Glu Glu Arg Ser Ser  Met Ala Ser 
    4010                 4015                 4020             


Ser Pro  Ile Ser Ser Ile Ser  Ala Asp Ser Phe Tyr  Ala Asp Ile 
    4025                 4030                 4035             


Asp His  His Thr Pro Arg Asn  Tyr Val Leu Ile Asp  Asp Ile Gly 
    4040                 4045                 4050             


Glu Ile  Thr Lys Gly Thr Ala  Ala Leu Ser Thr Ala  Phe Ser Leu 
    4055                 4060                 4065             


His Glu  Lys Asp Leu Ser Lys  Thr Asp Arg Leu Leu  Arg Thr Thr 
    4070                 4075                 4080             


Glu Thr  Arg Arg Ser Gln Glu  Val Thr Asp Phe Leu  Ala Pro Leu 
    4085                 4090                 4095             


Gln Ser  Ser Ser Arg Leu His  Ser Tyr Val Lys Ala  Glu Glu Asp 
    4100                 4105                 4110             


Pro Met  Glu Asp Pro Tyr Glu  Leu Lys Leu Leu Lys  His Gln Ile 
    4115                 4120                 4125             


Lys Gln  Glu Phe Arg Arg Gly  Thr Glu Ser Leu Asp  His Leu Ala 
    4130                 4135                 4140             


Gly Leu  Ser His Tyr Tyr His  Ala Asp Thr Ser Tyr  Arg His Phe 
    4145                 4150                 4155             


Pro Lys  Ser Glu Lys Tyr Ser  Ile Ser Arg Leu Thr  Leu Glu Lys 
    4160                 4165                 4170             


Gln Ala  Ala Lys Gln Leu Pro  Ala Ala Ile Leu Tyr  Gln Lys Gln 
    4175                 4180                 4185             


Ser Lys  His Lys Lys Ser Leu  Ile Asp Pro Lys Met  Ser Lys Phe 
    4190                 4195                 4200             


Ser Pro  Ile Gln Glu Ser Arg  Asp Leu Glu Pro Asp  Tyr Ser Ser 
    4205                 4210                 4215             


Tyr Met  Thr Ser Ser Thr Ser  Ser Ile Gly Gly Ile  Ser Ser Arg 
    4220                 4225                 4230             


Ala Arg  Leu Leu Gln Asp Asp  Ile Thr Phe Gly Leu  Arg Lys Asn 
    4235                 4240                 4245             


Ile Thr  Asp Gln Gln Lys Phe  Met Gly Ser Ser Leu  Gly Thr Gly 
    4250                 4255                 4260             


Leu Gly  Thr Leu Gly Asn Thr  Ile Arg Ser Ala Leu  Gln Asp Glu 
    4265                 4270                 4275             


Ala Asp  Lys Pro Tyr Ser Ser  Gly Ser Arg Ser Arg  Pro Ser Ser 
    4280                 4285                 4290             


Arg Pro  Ser Ser Val Tyr Gly  Leu Asp Leu Ser Ile  Lys Arg Asp 
    4295                 4300                 4305             


Ser Ser  Ser Ser Ser Leu Arg  Leu Lys Ala Gln Glu  Ala Glu Ala 
    4310                 4315                 4320             


Leu Asp  Val Ser Phe Ser His  Ala Ser Ser Ser Ala  Arg Thr Lys 
    4325                 4330                 4335             


Pro Thr  Ser Leu Pro Ile Ser  Gln Ser Arg Gly Arg  Ile Pro Ile 
    4340                 4345                 4350             


Val Ala  Gln Asn Ser Glu Glu  Glu Ser Pro Leu Ser  Pro Val Gly 
    4355                 4360                 4365             


Gln Pro  Met Gly Met Ala Arg  Ala Ala Ala Gly Pro  Leu Pro Pro 
    4370                 4375                 4380             


Ile Ser  Ala Asp Thr Arg Asp  Gln Phe Gly Ser Ser  His Ser Leu 
    4385                 4390                 4395             


Pro Glu  Val Gln Gln His Met  Arg Glu Glu Ser Arg  Thr Arg Gly 
    4400                 4405                 4410             


Tyr Asp  Arg Asp Ile Ala Phe  Ile Met Asp Asp Phe  Gln His Ala 
    4415                 4420                 4425             


Met Ser  Asp Ser Glu Ala Tyr  His Leu Arg Arg Glu  Glu Thr Asp 
    4430                 4435                 4440             


Trp Phe  Asp Lys Pro Arg Glu  Ser Arg Leu Glu Asn  Gly His Gly 
    4445                 4450                 4455             


Leu Asp  Arg Lys Leu Pro Glu  Arg Leu Val His Ser  Arg Pro Leu 
    4460                 4465                 4470             


Ser Gln  His Gln Glu Gln Ile  Ile Gln Met Asn Gly  Lys Thr Met 
    4475                 4480                 4485             


His Tyr  Ile Phe Pro His Ala  Arg Ile Lys Ile Thr  Arg Asp Ser 
    4490                 4495                 4500             


Lys Asp  His Thr Val Ser Gly  Asn Gly Leu Gly Ile  Arg Ile Val 
    4505                 4510                 4515             


Gly Gly  Lys Glu Ile Pro Gly  His Ser Gly Glu Ile  Gly Ala Tyr 
    4520                 4525                 4530             


Ile Ala  Lys Ile Leu Pro Gly  Gly Ser Ala Glu Gln  Thr Gly Lys 
    4535                 4540                 4545             


Leu Met  Glu Gly Met Gln Val  Leu Glu Trp Asn Gly  Ile Pro Leu 
    4550                 4555                 4560             


Thr Ser  Lys Thr Tyr Glu Glu  Val Gln Ser Ile Ile  Ser Gln Gln 
    4565                 4570                 4575             


Ser Gly  Glu Ala Glu Ile Cys  Val Arg Leu Asp Leu  Asn Met Leu 
    4580                 4585                 4590             


Ser Asp  Ser Glu Asn Ser Gln  His Leu Glu Leu His  Glu Pro Pro 
    4595                 4600                 4605             


Lys Ala  Val Asp Lys Ala Lys  Ser Pro Gly Val Asp  Pro Lys Gln 
    4610                 4615                 4620             


Leu Ala  Ala Glu Leu Gln Lys  Val Ser Leu Gln Gln  Ser Pro Leu 
    4625                 4630                 4635             


Val Leu  Ser Ser Val Val Glu  Lys Gly Ser His Val  His Ser Gly 
    4640                 4645                 4650             


Pro Thr  Ser Ala Gly Ser Ser  Ser Val Pro Ser Pro  Gly Gln Pro 
    4655                 4660                 4665             


Gly Ser  Pro Ser Val Ser Lys  Lys Lys His Gly Ser  Ser Lys Pro 
    4670                 4675                 4680             


Thr Asp  Gly Thr Lys Val Val  Ser His Pro Ile Thr  Gly Glu Ile 
    4685                 4690                 4695             


Gln Leu  Gln Ile Asn Tyr Asp  Leu Gly Asn Leu Ile  Ile His Ile 
    4700                 4705                 4710             


Leu Gln  Ala Arg Asn Leu Val  Pro Arg Asp Asn Asn  Gly Tyr Ser 
    4715                 4720                 4725             


Asp Pro  Phe Val Lys Val Tyr  Leu Leu Pro Gly Arg  Gly Gln Val 
    4730                 4735                 4740             


Met Val  Val Gln Asn Ala Ser  Ala Glu Tyr Lys Arg  Arg Thr Lys 
    4745                 4750                 4755             


His Val  Gln Lys Ser Leu Asn  Pro Glu Trp Asn Gln  Thr Val Ile 
    4760                 4765                 4770             


Tyr Lys  Ser Ile Ser Met Glu  Gln Leu Lys Lys Lys  Thr Leu Glu 
    4775                 4780                 4785             


Val Thr  Val Trp Asp Tyr Asp  Arg Phe Ser Ser Asn  Asp Phe Leu 
    4790                 4795                 4800             


Gly Glu  Val Leu Ile Asp Leu  Ser Ser Thr Ser His  Leu Asp Asn 
    4805                 4810                 4815             


Thr Pro  Arg Trp Tyr Pro Leu  Lys Glu Gln Thr Glu  Ser Ile Asp 
    4820                 4825                 4830             


His Gly  Lys Ser His Ser Ser  Gln Ser Ser Gln Gln  Ser Pro Lys 
    4835                 4840                 4845             


Pro Ser  Val Ile Lys Ser Arg  Ser His Gly Ile Phe  Pro Asp Pro 
    4850                 4855                 4860             


Ser Lys  Asp Met Gln Val Pro  Thr Ile Glu Lys Ser  His Ser Ser 
    4865                 4870                 4875             


Pro Gly  Ser Ser Lys Ser Ser  Ser Glu Gly His Leu  Arg Ser His 
    4880                 4885                 4890             


Gly Pro  Ser Arg Ser Gln Ser  Lys Thr Ser Val Thr  Gln Thr His 
    4895                 4900                 4905             


Leu Glu  Asp Ala Gly Ala Ala  Ile Ala Ala Ala Glu  Ala Ala Val 
    4910                 4915                 4920             


Gln Gln  Leu Arg Ile Gln Pro  Thr Lys Pro Pro Asn  His Arg Pro 
    4925                 4930                 4935             


Ala Glu  Ser Ser Val Ser Thr  Gly Ser Ser Gly Ser  Ser Phe Gly 
    4940                 4945                 4950             


Ser Gly  Tyr Ser Val Asp Ser  Glu Gly Ser Ser Ser  Thr Ala Gly 
    4955                 4960                 4965             


Glu Thr  Asn Leu Phe Pro Ile  Pro Arg Ile Gly Lys  Met Gly Gln 
    4970                 4975                 4980             


Asn Gly  Gln Glu Pro Val Lys  Gln Pro Gly Val Gly  Val Gly Leu 
    4985                 4990                 4995             


Ala Asp  Thr Glu Ala Lys Thr  Gln Val Met Gly Glu  Ile Lys Ile 
    5000                 5005                 5010             


Ala Leu  Lys Lys Glu Met Lys  Thr Asp Gly Glu Gln  Leu Ile Val 
    5015                 5020                 5025             


Glu Ile  Leu Gln Cys Arg Asn  Ile Thr Tyr Lys Phe  Lys Ser Pro 
    5030                 5035                 5040             


Asp His  Leu Pro Asp Leu Tyr  Val Lys Ile Tyr Val  Met Asn Ile 
    5045                 5050                 5055             


Ser Thr  Gln Lys Lys Val Ile  Lys Lys Lys Thr Arg  Val Cys Arg 
    5060                 5065                 5070             


His Asp  Arg Glu Pro Ser Phe  Asn Glu Thr Phe Arg  Phe Ser Leu 
    5075                 5080                 5085             


Ser Pro  Ala Gly His Ser Leu  Gln Ile Leu Leu Phe  Ser Asn Gly 
    5090                 5095                 5100             


Gly Lys  Phe Met Lys Lys Thr  Leu Ile Gly Glu Ala  Cys Ile Trp 
    5105                 5110                 5115             


Leu Asp  Lys Val Asp Leu Arg  Lys Arg Ile Val Asn  Trp His Lys 
    5120                 5125                 5130             


Leu Leu  Val Ser Pro Thr Gln  Thr His 
    5135                 5140         


<210>  5439
<211>  519
<212>  PRT
<213>  Homo sapiens

<400>  5439

Met Ala Glu Glu Arg Val Ala Thr Arg Thr Gln Phe Pro Val Ser Thr 
1               5                   10                  15      


Glu Ser Gln Lys Pro Arg Gln Lys Lys Ala Pro Glu Phe Pro Ile Leu 
            20                  25                  30          


Glu Lys Gln Asn Trp Leu Ile His Leu His Tyr Ile Arg Lys Asp Tyr 
        35                  40                  45              


Glu Ala Cys Lys Ala Val Ile Lys Glu Gln Leu Gln Glu Thr Gln Gly 
    50                  55                  60                  


Leu Cys Glu Tyr Ala Ile Tyr Val Gln Ala Leu Ile Phe Arg Leu Glu 
65                  70                  75                  80  


Gly Asn Ile Gln Glu Ser Leu Glu Leu Phe Gln Thr Cys Ala Val Leu 
                85                  90                  95      


Ser Pro Gln Ser Ala Asp Asn Leu Lys Gln Val Ala Arg Ser Leu Phe 
            100                 105                 110         


Leu Leu Gly Lys His Lys Ala Ala Ile Glu Val Tyr Asn Glu Ala Ala 
        115                 120                 125             


Lys Leu Asn Gln Lys Asp Trp Glu Ile Ser His Asn Leu Gly Val Cys 
    130                 135                 140                 


Tyr Ile Tyr Leu Lys Gln Phe Asn Lys Ala Gln Asp Gln Leu His Asn 
145                 150                 155                 160 


Ala Leu Asn Leu Asn Arg His Asp Leu Thr Tyr Ile Met Leu Gly Lys 
                165                 170                 175     


Ile His Leu Leu Glu Gly Asp Leu Asp Lys Ala Ile Glu Val Tyr Lys 
            180                 185                 190         


Lys Ala Val Glu Phe Ser Pro Glu Asn Thr Glu Leu Leu Thr Thr Leu 
        195                 200                 205             


Gly Leu Leu Tyr Leu Gln Leu Gly Ile Tyr Gln Lys Ala Phe Glu His 
    210                 215                 220                 


Leu Gly Asn Ala Leu Thr Tyr Asp Pro Thr Asn Tyr Lys Ala Ile Leu 
225                 230                 235                 240 


Ala Ala Gly Ser Met Met Gln Thr His Gly Asp Phe Asp Val Ala Leu 
                245                 250                 255     


Thr Lys Tyr Arg Val Val Ala Cys Ala Val Pro Glu Ser Pro Pro Leu 
            260                 265                 270         


Trp Asn Asn Ile Gly Met Cys Phe Phe Gly Lys Lys Lys Tyr Val Ala 
        275                 280                 285             


Ala Ile Ser Cys Leu Lys Arg Ala Asn Tyr Leu Ala Pro Phe Asp Trp 
    290                 295                 300                 


Lys Ile Leu Tyr Asn Leu Gly Leu Val His Leu Thr Met Gln Gln Tyr 
305                 310                 315                 320 


Ala Ser Ala Phe His Phe Leu Ser Ala Ala Ile Asn Phe Gln Pro Lys 
                325                 330                 335     


Met Gly Glu Leu Tyr Met Leu Leu Ala Val Ala Leu Thr Asn Leu Glu 
            340                 345                 350         


Asp Ile Glu Asn Ala Lys Arg Ala Tyr Ala Glu Ala Val His Leu Asp 
        355                 360                 365             


Lys Cys Asn Pro Leu Val Asn Leu Asn Tyr Ala Val Leu Leu Tyr Asn 
    370                 375                 380                 


Gln Gly Glu Lys Lys Asn Ala Leu Ala Gln Tyr Gln Glu Met Glu Lys 
385                 390                 395                 400 


Lys Val Ser Leu Leu Lys Asp Asn Ser Ser Leu Glu Phe Asp Ser Glu 
                405                 410                 415     


Met Val Glu Met Ala Gln Lys Leu Gly Ala Ala Leu Gln Val Gly Glu 
            420                 425                 430         


Ala Leu Val Trp Thr Lys Pro Val Lys Asp Pro Lys Ser Lys His Gln 
        435                 440                 445             


Thr Thr Ser Thr Ser Lys Pro Ala Ser Phe Gln Gln Pro Leu Gly Ser 
    450                 455                 460                 


Asn Gln Ala Leu Gly Gln Ala Met Ser Ser Ala Ala Ala Tyr Arg Thr 
465                 470                 475                 480 


Leu Pro Ser Gly Ala Gly Gly Thr Ser Gln Phe Thr Lys Pro Pro Ser 
                485                 490                 495     


Leu Pro Leu Glu Pro Glu Pro Ala Val Glu Ser Ser Pro Thr Glu Thr 
            500                 505                 510         


Ser Glu Gln Ile Arg Glu Lys 
        515                 


<210>  5440
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  5440

Met Val Thr Thr Leu Gly Pro Lys Met Ala Ala Glu Trp Gly Gly Gly 
1               5                   10                  15      


Val Gly Tyr Ser Gly Ser Gly Pro Gly Arg Ser Arg Trp Arg Trp Ser 
            20                  25                  30          


Gly Ser Val Trp Val Arg Ser Val Leu Leu Leu Leu Gly Gly Leu Arg 
        35                  40                  45              


Ala Ser Ala Thr Ser Thr Pro Val Ser Leu Gly Ser Ser Pro Pro Cys 
    50                  55                  60                  


Arg His His Val Pro Ser Asp Thr Glu Val Ile Asn Lys Val His Leu 
65                  70                  75                  80  


Lys Ala Asn His Val Val Lys Arg Asp Val Asp Glu His Leu Arg Ile 
                85                  90                  95      


Lys Thr Val Tyr Asp Lys Ser Val Glu Glu Leu Leu Pro Glu Lys Lys 
            100                 105                 110         


Asn Leu Val Lys Asn Lys Leu Phe Pro Gln Ala Ile Ser Tyr Leu Glu 
        115                 120                 125             


Lys Thr Phe Gln Val Arg Arg Pro Ala Gly Thr Ile Leu Leu Ser Arg 
    130                 135                 140                 


Gln Cys Ala Thr Asn Gln Tyr Leu Arg Lys Glu Asn Asp Pro His Arg 
145                 150                 155                 160 


Tyr Cys Thr Gly Glu Cys Ala Ala His Thr Lys Cys Gly Pro Val Ile 
                165                 170                 175     


Val Pro Glu Glu His Leu Gln Gln Cys Arg Val Tyr Arg Gly Gly Lys 
            180                 185                 190         


Trp Pro His Gly Ala Val Gly Val Pro Asp Gln Glu Gly Ile Ser Asp 
        195                 200                 205             


Ala Asp Phe Val Leu Tyr Val Gly Ala Leu Ala Thr Glu Arg Cys Ser 
    210                 215                 220                 


His Glu Asn Ile Ile Ser Tyr Ala Ala Tyr Cys Gln Gln Glu Ala Asn 
225                 230                 235                 240 


Met Asp Arg Pro Ile Ala Gly Tyr Ala Asn Leu Cys Pro Asn Met Ile 
                245                 250                 255     


Ser Thr Gln Pro Gln Glu Phe Val Gly Met Leu Ser Thr Val Lys His 
            260                 265                 270         


Glu Val Ile His Ala Leu Gly Phe Ser Ala Gly Leu Phe Ala Phe Tyr 
        275                 280                 285             


His Asp Lys Asp Gly Asn Pro Leu Thr Ser Arg Phe Ala Asp Gly Leu 
    290                 295                 300                 


Pro Pro Phe Asn Tyr Ser Leu Gly Leu Tyr Gln Trp Ser Asp Lys Val 
305                 310                 315                 320 


Val Arg Lys Val Glu Arg Leu Trp Asp Val Arg Asp Asn Lys Ile Val 
                325                 330                 335     


Arg His Thr Val Tyr Leu Leu Val Thr Pro Arg Val Val Glu Glu Ala 
            340                 345                 350         


Arg Lys His Phe Asp Cys Pro Val Leu Glu Gly Met Glu Leu Glu Asn 
        355                 360                 365             


Gln Gly Gly Val Gly Thr Glu Leu Asn His Trp Glu Lys Arg Leu Leu 
    370                 375                 380                 


Glu Asn Glu Ala Met Thr Gly Ser His Thr Gln Asn Arg Val Leu Ser 
385                 390                 395                 400 


Arg Ile Thr Leu Ala Leu Met Glu Asp Thr Gly Arg Gln Met Leu Ser 
                405                 410                 415     


Pro Tyr Cys Asp Thr Leu Arg Ser Asn Pro Leu Gln Leu Thr Cys Arg 
            420                 425                 430         


Gln Asp Gln Arg Ala Val Ala Val Cys Asn Leu Gln Lys Phe Pro Lys 
        435                 440                 445             


Pro Leu Pro Gln Glu Tyr Gln Tyr Phe Asp Glu Leu Ser Gly Ile Pro 
    450                 455                 460                 


Ala Glu Asp Leu Pro Tyr Tyr Gly Gly Ser Val Glu Ile Ala Asp Tyr 
465                 470                 475                 480 


Cys Pro Phe Ser Gln Glu Phe Ser Trp His Leu Ser Gly Glu Tyr Gln 
                485                 490                 495     


Arg Ser Ser Asp Cys Arg Ile Leu Glu Asn Gln Pro Glu Ile Phe Lys 
            500                 505                 510         


Asn Tyr Gly Ala Glu Lys Tyr Gly Pro His Ser Val Cys Leu Ile Gln 
        515                 520                 525             


Lys Ser Ala Phe Val Met Glu Lys Cys Glu Arg Lys Leu Ser Tyr Pro 
    530                 535                 540                 


Asp Trp Gly Ser Gly Cys Tyr Gln Val Ser Cys Ser Pro Gln Gly Leu 
545                 550                 555                 560 


Lys Val Trp Val Gln Asp Thr Ser Tyr Leu Cys Ser Arg Ala Gly Gln 
                565                 570                 575     


Val Leu Pro Val Ser Ile Gln Met Asn Gly Trp Ile His Asp Gly Asn 
            580                 585                 590         


Leu Leu Cys Pro Ser Cys Trp Asp Phe Cys Glu Leu Cys Pro Pro Glu 
        595                 600                 605             


Thr Asp Pro Pro Ala Thr Asn Leu Thr Arg Ala Leu Pro Leu Asp Leu 
    610                 615                 620                 


Cys Ser Cys Ser Ser Ser Leu Val Val Thr Leu Trp Leu Leu Leu Gly 
625                 630                 635                 640 


Asn Leu Phe Pro Leu Leu Ala Gly Phe Leu Leu Cys Ile Trp His 
                645                 650                 655 


<210>  5441
<211>  5430
<212>  PRT
<213>  Homo sapiens

<400>  5441

Met Ser Ser Ser Asp Glu Glu Thr Leu Ser Glu Arg Ser Cys Arg Ser 
1               5                   10                  15      


Glu Arg Ser Cys Arg Ser Glu Arg Ser Tyr Arg Ser Glu Arg Ser Gly 
            20                  25                  30          


Ser Leu Ser Pro Cys Pro Pro Gly Asp Thr Leu Pro Trp Asn Leu Pro 
        35                  40                  45              


Leu His Glu Gln Lys Lys Arg Lys Ser Gln Asp Ser Val Leu Asp Pro 
    50                  55                  60                  


Ala Glu Arg Ala Val Val Arg Val Ala Asp Glu Arg Asp Arg Val Gln 
65                  70                  75                  80  


Lys Lys Thr Phe Thr Lys Trp Val Asn Lys His Leu Met Lys Val Arg 
                85                  90                  95      


Lys His Ile Asn Asp Leu Tyr Glu Asp Leu Arg Asp Gly His Asn Leu 
            100                 105                 110         


Ile Ser Leu Leu Glu Val Leu Ser Gly Ile Lys Leu Pro Arg Glu Lys 
        115                 120                 125             


Gly Arg Met Arg Phe His Arg Leu Gln Asn Val Gln Ile Ala Leu Asp 
    130                 135                 140                 


Phe Leu Lys Gln Arg Gln Val Lys Leu Val Asn Ile Arg Asn Asp Asp 
145                 150                 155                 160 


Ile Thr Asp Gly Asn Pro Lys Leu Thr Leu Gly Leu Ile Trp Thr Ile 
                165                 170                 175     


Ile Leu His Phe Gln Ile Ser Asp Ile Tyr Ile Ser Gly Glu Ser Gly 
            180                 185                 190         


Asp Met Ser Ala Lys Glu Lys Leu Leu Leu Trp Thr Gln Lys Val Thr 
        195                 200                 205             


Ala Gly Tyr Thr Gly Ile Lys Cys Thr Asn Phe Ser Ser Cys Trp Ser 
    210                 215                 220                 


Asp Gly Lys Met Phe Asn Ala Leu Ile His Arg Tyr Arg Pro Asp Leu 
225                 230                 235                 240 


Val Asp Met Glu Arg Val Gln Ile Gln Ser Asn Arg Glu Asn Leu Glu 
                245                 250                 255     


Gln Ala Phe Glu Val Ala Glu Arg Leu Gly Val Thr Arg Leu Leu Asp 
            260                 265                 270         


Ala Glu Asp Val Asp Val Pro Ser Pro Asp Glu Lys Ser Val Ile Thr 
        275                 280                 285             


Tyr Val Ser Ser Ile Tyr Asp Ala Phe Pro Lys Val Pro Glu Gly Gly 
    290                 295                 300                 


Glu Gly Ile Ser Ala Thr Glu Val Asp Ser Arg Trp Gln Glu Tyr Gln 
305                 310                 315                 320 


Ser Arg Val Asp Ser Leu Ile Pro Trp Ile Lys Gln His Thr Ile Leu 
                325                 330                 335     


Met Ser Asp Lys Thr Phe Pro Gln Asn Pro Val Glu Leu Lys Ala Leu 
            340                 345                 350         


Tyr Asn Gln Tyr Ile His Phe Lys Glu Thr Glu Ile Leu Ala Lys Glu 
        355                 360                 365             


Arg Glu Lys Gly Arg Ile Glu Glu Leu Tyr Lys Leu Leu Glu Val Trp 
    370                 375                 380                 


Ile Glu Phe Gly Arg Ile Lys Leu Pro Gln Gly Tyr His Pro Asn Asp 
385                 390                 395                 400 


Val Glu Glu Glu Trp Gly Lys Leu Ile Ile Glu Met Leu Glu Arg Glu 
                405                 410                 415     


Lys Ser Leu Arg Pro Ala Val Glu Arg Leu Glu Leu Leu Leu Gln Ile 
            420                 425                 430         


Ala Asn Lys Ile Gln Asn Gly Ala Leu Asn Cys Glu Glu Lys Leu Thr 
        435                 440                 445             


Leu Ala Lys Asn Thr Leu Gln Ala Asp Ala Ala His Leu Glu Ser Gly 
    450                 455                 460                 


Gln Pro Val Gln Cys Glu Ser Asp Val Ile Met Tyr Ile Gln Glu Cys 
465                 470                 475                 480 


Glu Gly Leu Ile Arg Gln Leu Gln Val Asp Leu Gln Ile Leu Arg Asp 
                485                 490                 495     


Glu Asn Tyr Tyr Gln Leu Glu Glu Leu Ala Phe Arg Val Met Arg Leu 
            500                 505                 510         


Gln Asp Glu Leu Val Thr Leu Arg Leu Glu Cys Thr Asn Leu Tyr Arg 
        515                 520                 525             


Lys Gly His Phe Thr Ser Leu Glu Leu Val Pro Pro Ser Thr Leu Thr 
    530                 535                 540                 


Thr Thr His Leu Lys Ala Glu Pro Leu Thr Lys Ala Thr His Ser Ser 
545                 550                 555                 560 


Ser Thr Ser Trp Phe Arg Lys Pro Met Thr Arg Ala Glu Leu Val Ala 
                565                 570                 575     


Ile Ser Ser Ser Glu Asp Glu Gly Asn Leu Arg Phe Val Tyr Glu Leu 
            580                 585                 590         


Leu Ser Trp Val Glu Glu Met Gln Met Lys Leu Glu Arg Ala Glu Trp 
        595                 600                 605             


Gly Asn Asp Leu Pro Ser Val Glu Leu Gln Leu Glu Thr Gln Gln His 
    610                 615                 620                 


Ile His Thr Ser Val Glu Glu Leu Gly Ser Ser Val Lys Glu Ala Arg 
625                 630                 635                 640 


Leu Tyr Glu Gly Lys Met Ser Gln Asn Phe His Thr Ser Tyr Ala Glu 
                645                 650                 655     


Thr Leu Gly Lys Leu Glu Thr Gln Tyr Cys Lys Leu Lys Glu Thr Ser 
            660                 665                 670         


Ser Phe Arg Met Arg His Leu Gln Ser Leu His Lys Phe Val Ser Arg 
        675                 680                 685             


Ala Thr Ala Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu Leu 
    690                 695                 700                 


Ala Tyr Asp Trp Ser Asp Asn Asn Ser Asn Ile Ser Ala Lys Arg Asn 
705                 710                 715                 720 


Tyr Phe Ser Glu Leu Thr Met Glu Leu Glu Glu Lys Gln Asp Val Phe 
                725                 730                 735     


Arg Ser Leu Gln Asp Thr Ala Glu Leu Leu Ser Leu Glu Asn His Pro 
            740                 745                 750         


Ala Lys Gln Thr Val Glu Ala Tyr Ser Ala Ala Val Gln Ser Gln Leu 
        755                 760                 765             


Gln Trp Met Lys Gln Leu Cys Leu Cys Val Glu Gln His Val Lys Glu 
    770                 775                 780                 


Asn Thr Ala Tyr Phe Gln Phe Phe Ser Asp Ala Arg Glu Leu Glu Ser 
785                 790                 795                 800 


Phe Leu Arg Asn Leu Gln Asp Ser Ile Lys Arg Lys Tyr Ser Cys Asp 
                805                 810                 815     


His Asn Thr Ser Leu Ser Arg Leu Glu Asp Leu Leu Gln Asp Ser Met 
            820                 825                 830         


Asp Glu Lys Glu Gln Leu Ile Gln Ser Lys Ser Ser Val Ala Ser Leu 
        835                 840                 845             


Val Gly Arg Ser Lys Thr Ile Val Gln Leu Lys Pro Arg Ser Pro Asp 
    850                 855                 860                 


His Val Leu Lys Asn Thr Ile Ser Val Lys Ala Val Cys Asp Tyr Arg 
865                 870                 875                 880 


Gln Ile Glu Ile Thr Ile Cys Lys Asn Asp Glu Cys Val Leu Glu Asp 
                885                 890                 895     


Asn Ser Gln Arg Thr Lys Trp Lys Val Ile Ser Pro Thr Gly Asn Glu 
            900                 905                 910         


Ala Met Val Pro Ser Val Cys Phe Leu Ile Pro Pro Pro Asn Lys Asp 
        915                 920                 925             


Ala Ile Glu Met Ala Ser Arg Val Glu Gln Ser Tyr Gln Lys Val Met 
    930                 935                 940                 


Ala Leu Trp His Gln Leu His Val Asn Thr Lys Ser Leu Ile Ser Trp 
945                 950                 955                 960 


Asn Tyr Leu Arg Lys Asp Leu Asp Leu Val Gln Thr Trp Asn Leu Glu 
                965                 970                 975     


Lys Leu Arg Ser Ser Ala Pro Gly Glu Cys His Gln Ile Met Lys Asn 
            980                 985                 990         


Leu Gln Ala His Tyr Glu Asp Phe  Leu Gln Asp Ser Arg  Asp Ser Val 
        995                 1000                 1005             


Leu Phe  Ser Val Ala Asp Arg  Leu Arg Leu Glu Glu  Glu Val Glu 
    1010                 1015                 1020             


Ala Cys  Lys Ala Arg Phe Gln  His Leu Met Lys Ser  Met Glu Asn 
    1025                 1030                 1035             


Glu Asp  Lys Glu Glu Thr Val  Ala Lys Met Tyr Ile  Ser Glu Leu 
    1040                 1045                 1050             


Lys Asn  Ile Arg Leu Arg Leu  Glu Glu Tyr Glu Gln  Arg Val Val 
    1055                 1060                 1065             


Lys Arg  Ile Gln Ser Leu Ala  Ser Ser Arg Thr Asp  Arg Asp Ala 
    1070                 1075                 1080             


Trp Gln  Asp Asn Ala Leu Arg  Ile Ala Glu Gln Glu  His Thr Gln 
    1085                 1090                 1095             


Glu Asp  Leu Gln Gln Leu Arg  Ser Asp Leu Asp Ala  Val Ser Met 
    1100                 1105                 1110             


Lys Cys  Asp Ser Phe Leu His  Gln Ser Pro Ser Ser  Ser Ser Val 
    1115                 1120                 1125             


Pro Thr  Leu Arg Ser Glu Leu  Asn Leu Leu Val Glu  Lys Met Asp 
    1130                 1135                 1140             


His Val  Tyr Gly Leu Ser Thr  Val Tyr Leu Asn Lys  Leu Lys Thr 
    1145                 1150                 1155             


Val Asp  Val Ile Val Arg Ser  Ile Gln Asp Ala Glu  Leu Leu Val 
    1160                 1165                 1170             


Lys Gly  Tyr Glu Ile Lys Leu  Ser Gln Glu Glu Val  Val Leu Ala 
    1175                 1180                 1185             


Asp Leu  Ser Ala Leu Glu Ala  His Trp Ser Thr Leu  Arg His Trp 
    1190                 1195                 1200             


Leu Ser  Asp Val Lys Asp Lys  Asn Ser Val Phe Ser  Val Leu Asp 
    1205                 1210                 1215             


Glu Glu  Ile Ala Lys Ala Lys  Val Val Ala Glu Gln  Met Ser Arg 
    1220                 1225                 1230             


Leu Thr  Pro Glu Arg Asn Leu  Asp Leu Glu Arg Tyr  Gln Glu Lys 
    1235                 1240                 1245             


Gly Ser  Gln Leu Gln Glu Arg  Trp His Arg Val Ile  Ala Gln Leu 
    1250                 1255                 1260             


Glu Ile  Arg Gln Ser Glu Leu  Glu Ser Ile Gln Glu  Val Leu Gly 
    1265                 1270                 1275             


Asp Tyr  Arg Ala Cys His Gly  Thr Leu Ile Lys Trp  Ile Glu Glu 
    1280                 1285                 1290             


Thr Thr  Ala Gln Gln Glu Met  Met Lys Pro Gly Gln  Ala Glu Asp 
    1295                 1300                 1305             


Ser Arg  Val Leu Ser Glu Gln  Leu Ser Gln Gln Thr  Ala Leu Phe 
    1310                 1315                 1320             


Ala Glu  Ile Glu Arg Asn Gln  Thr Lys Leu Asp Gln  Cys Gln Lys 
    1325                 1330                 1335             


Phe Ser  Gln Gln Tyr Ser Thr  Ile Val Lys Asp Tyr  Glu Leu Gln 
    1340                 1345                 1350             


Leu Met  Thr Tyr Lys Ala Phe  Val Glu Ser Gln Gln  Lys Ser Pro 
    1355                 1360                 1365             


Gly Lys  Arg Arg Arg Met Leu  Ser Ser Ser Asp Ala  Ile Thr Gln 
    1370                 1375                 1380             


Glu Phe  Met Asp Leu Arg Thr  Arg Tyr Thr Ala Leu  Val Thr Leu 
    1385                 1390                 1395             


Thr Thr  Gln His Val Lys Tyr  Ile Ser Asp Ala Leu  Arg Arg Leu 
    1400                 1405                 1410             


Glu Glu  Glu Glu Lys Val Val  Glu Glu Glu Lys Gln  Glu His Val 
    1415                 1420                 1425             


Glu Lys  Val Lys Glu Leu Leu  Gly Trp Val Ser Thr  Leu Ala Arg 
    1430                 1435                 1440             


Asn Thr  Gln Gly Lys Ala Thr  Ser Ser Glu Thr Lys  Glu Ser Thr 
    1445                 1450                 1455             


Asp Ile  Glu Lys Ala Ile Leu  Glu Gln Gln Val Leu  Ser Glu Glu 
    1460                 1465                 1470             


Leu Thr  Thr Lys Lys Glu Gln  Val Ser Glu Ala Ile  Lys Thr Ser 
    1475                 1480                 1485             


Gln Ile  Phe Leu Ala Lys His  Gly His Lys Leu Ser  Glu Lys Glu 
    1490                 1495                 1500             


Lys Lys  Gln Ile Ser Glu Gln  Leu Asn Ala Leu Asn  Lys Ala Tyr 
    1505                 1510                 1515             


His Asp  Leu Cys Asp Gly Ser  Ala Asn Gln Leu Gln  Gln Leu Gln 
    1520                 1525                 1530             


Ser Gln  Leu Ala His Gln Thr  Glu Gln Lys Thr Leu  Gln Lys Gln 
    1535                 1540                 1545             


Gln Asn  Thr Cys His Gln Gln  Leu Glu Asp Leu Cys  Ser Trp Val 
    1550                 1555                 1560             


Gly Gln  Ala Glu Arg Ala Leu  Ala Gly His Gln Gly  Arg Thr Thr 
    1565                 1570                 1575             


Gln Gln  Asp Leu Ser Ala Leu  Gln Lys Asn Gln Ser  Asp Leu Lys 
    1580                 1585                 1590             


Asp Leu  Gln Asp Asp Ile Gln  Asn Arg Ala Thr Ser  Phe Ala Thr 
    1595                 1600                 1605             


Val Val  Lys Asp Ile Glu Gly  Phe Met Glu Glu Asn  Gln Thr Lys 
    1610                 1615                 1620             


Leu Ser  Pro Arg Glu Leu Thr  Ala Leu Arg Glu Lys  Leu His Gln 
    1625                 1630                 1635             


Ala Lys  Glu Gln Tyr Glu Ala  Leu Gln Glu Glu Thr  Arg Val Ala 
    1640                 1645                 1650             


Gln Lys  Glu Leu Glu Glu Ala  Val Thr Ser Ala Leu  Gln Gln Glu 
    1655                 1660                 1665             


Thr Glu  Lys Ser Lys Ala Ala  Lys Glu Leu Ala Glu  Asn Lys Lys 
    1670                 1675                 1680             


Lys Ile  Asp Ala Leu Leu Asp  Trp Val Thr Ser Val  Gly Ser Ser 
    1685                 1690                 1695             


Gly Gly  Gln Leu Leu Thr Asn  Leu Pro Gly Met Glu  Gln Leu Ser 
    1700                 1705                 1710             


Gly Ala  Ser Leu Glu Lys Gly  Ala Leu Asp Thr Thr  Asp Gly Tyr 
    1715                 1720                 1725             


Met Gly  Val Asn Gln Ala Pro  Glu Lys Leu Asp Lys  Gln Cys Glu 
    1730                 1735                 1740             


Met Met  Lys Ala Arg His Gln  Glu Leu Leu Ser Gln  Gln Gln Asn 
    1745                 1750                 1755             


Phe Ile  Leu Ala Thr Gln Ser  Ala Gln Ala Phe Leu  Asp Gln His 
    1760                 1765                 1770             


Gly His  Asn Leu Thr Pro Glu  Glu Gln Gln Met Leu  Gln Gln Lys 
    1775                 1780                 1785             


Leu Gly  Glu Leu Lys Glu Gln  Tyr Ser Thr Ser Leu  Ala Gln Ser 
    1790                 1795                 1800             


Glu Ala  Glu Leu Lys Gln Val  Gln Thr Leu Gln Asp  Glu Leu Gln 
    1805                 1810                 1815             


Lys Phe  Leu Gln Asp His Lys  Glu Phe Glu Ser Trp  Leu Glu Arg 
    1820                 1825                 1830             


Ser Glu  Lys Glu Leu Glu Asn  Met His Lys Gly Gly  Ser Ser Pro 
    1835                 1840                 1845             


Glu Thr  Leu Pro Ser Leu Leu  Lys Arg Gln Gly Ser  Phe Ser Glu 
    1850                 1855                 1860             


Asp Val  Ile Ser His Lys Gly  Asp Leu Arg Phe Val  Thr Ile Ser 
    1865                 1870                 1875             


Gly Gln  Lys Val Leu Asp Met  Glu Asn Ser Phe Lys  Glu Gly Lys 
    1880                 1885                 1890             


Glu Pro  Ser Glu Ile Gly Asn  Leu Val Lys Asp Lys  Leu Lys Asp 
    1895                 1900                 1905             


Ala Thr  Glu Arg Tyr Thr Ala  Leu His Ser Lys Cys  Thr Arg Leu 
    1910                 1915                 1920             


Gly Ser  His Leu Asn Met Leu  Leu Gly Gln Tyr His  Gln Phe Gln 
    1925                 1930                 1935             


Asn Ser  Ala Asp Ser Leu Gln  Ala Trp Met Gln Ala  Cys Glu Ala 
    1940                 1945                 1950             


Asn Val  Glu Lys Leu Leu Ser  Asp Thr Val Ala Ser  Asp Pro Gly 
    1955                 1960                 1965             


Val Leu  Gln Glu Gln Leu Ala  Thr Thr Lys Gln Leu  Gln Glu Glu 
    1970                 1975                 1980             


Leu Ala  Glu His Gln Val Pro  Val Glu Lys Leu Gln  Lys Val Ala 
    1985                 1990                 1995             


Arg Asp  Ile Met Glu Ile Glu  Gly Glu Pro Ala Pro  Asp His Arg 
    2000                 2005                 2010             


His Val  Gln Glu Thr Thr Asp  Ser Ile Leu Ser His  Phe Gln Ser 
    2015                 2020                 2025             


Leu Ser  Tyr Ser Leu Ala Glu  Arg Ser Ser Leu Leu  Gln Lys Ala 
    2030                 2035                 2040             


Ile Ala  Gln Ser Gln Ser Val  Gln Glu Ser Leu Glu  Ser Leu Leu 
    2045                 2050                 2055             


Gln Ser  Ile Gly Glu Val Glu  Gln Asn Leu Glu Gly  Lys Gln Val 
    2060                 2065                 2070             


Ser Ser  Leu Ser Ser Gly Val  Ile Gln Glu Ala Leu  Ala Thr Asn 
    2075                 2080                 2085             


Met Lys  Leu Lys Gln Asp Ile  Ala Arg Gln Lys Ser  Ser Leu Glu 
    2090                 2095                 2100             


Ala Thr  Arg Glu Met Val Thr  Arg Phe Met Glu Thr  Ala Asp Ser 
    2105                 2110                 2115             


Thr Thr  Ala Ala Val Leu Gln  Gly Lys Leu Ala Glu  Val Ser Gln 
    2120                 2125                 2130             


Arg Phe  Glu Gln Leu Cys Leu  Gln Gln Gln Glu Lys  Glu Ser Ser 
    2135                 2140                 2145             


Leu Lys  Lys Leu Leu Pro Gln  Ala Glu Met Phe Glu  His Leu Ser 
    2150                 2155                 2160             


Gly Lys  Leu Gln Gln Phe Met  Glu Asn Lys Ser Arg  Met Leu Ala 
    2165                 2170                 2175             


Ser Gly  Asn Gln Pro Asp Gln  Asp Ile Thr His Phe  Phe Gln Gln 
    2180                 2185                 2190             


Ile Gln  Glu Leu Asn Leu Glu  Met Glu Asp Gln Gln  Glu Asn Leu 
    2195                 2200                 2205             


Asp Thr  Leu Glu His Leu Val  Thr Glu Leu Ser Ser  Cys Gly Phe 
    2210                 2215                 2220             


Ala Leu  Asp Leu Cys Gln His  Gln Asp Arg Val Gln  Asn Leu Arg 
    2225                 2230                 2235             


Lys Asp  Phe Thr Glu Leu Gln  Lys Thr Val Lys Glu  Arg Glu Lys 
    2240                 2245                 2250             


Asp Ala  Ser Ser Cys Gln Glu  Gln Leu Asp Glu Phe  Arg Lys Leu 
    2255                 2260                 2265             


Val Arg  Thr Phe Gln Lys Trp  Leu Lys Glu Thr Glu  Gly Ser Ile 
    2270                 2275                 2280             


Pro Pro  Thr Glu Thr Ser Met  Ser Ala Lys Glu Leu  Glu Lys Gln 
    2285                 2290                 2295             


Ile Glu  His Leu Lys Ser Leu  Leu Asp Asp Trp Ala  Ser Lys Gly 
    2300                 2305                 2310             


Thr Leu  Val Glu Glu Ile Asn  Cys Lys Gly Thr Ser  Leu Glu Asn 
    2315                 2320                 2325             


Leu Ile  Met Glu Ile Thr Ala  Pro Asp Ser Gln Gly  Lys Thr Gly 
    2330                 2335                 2340             


Ser Ile  Leu Pro Ser Val Gly  Ser Ser Val Gly Ser  Val Asn Gly 
    2345                 2350                 2355             


Tyr His  Thr Cys Lys Asp Leu  Thr Glu Ile Gln Cys  Asp Met Ser 
    2360                 2365                 2370             


Asp Val  Asn Leu Lys Tyr Glu  Lys Leu Gly Gly Val  Leu His Glu 
    2375                 2380                 2385             


Arg Gln  Glu Ser Leu Gln Ala  Ile Leu Asn Arg Met  Glu Glu Val 
    2390                 2395                 2400             


His Lys  Glu Ala Asn Ser Val  Leu Gln Trp Leu Glu  Ser Lys Glu 
    2405                 2410                 2415             


Glu Val  Leu Lys Ser Met Asp  Ala Met Ser Ser Pro  Thr Lys Thr 
    2420                 2425                 2430             


Glu Thr  Val Lys Ala Gln Ala  Glu Ser Asn Lys Ala  Phe Leu Ala 
    2435                 2440                 2445             


Glu Leu  Glu Gln Asn Ser Pro  Lys Ile Gln Lys Val  Lys Glu Ala 
    2450                 2455                 2460             


Leu Ala  Gly Leu Leu Val Thr  Tyr Pro Asn Ser Gln  Glu Ala Glu 
    2465                 2470                 2475             


Asn Trp  Lys Lys Ile Gln Glu  Glu Leu Asn Ser Arg  Trp Glu Arg 
    2480                 2485                 2490             


Ala Thr  Glu Val Thr Val Ala  Arg Gln Arg Gln Leu  Glu Glu Ser 
    2495                 2500                 2505             


Ala Ser  His Leu Ala Cys Phe  Gln Ala Ala Glu Ser  Gln Leu Arg 
    2510                 2515                 2520             


Pro Trp  Leu Met Glu Lys Glu  Leu Met Met Gly Val  Leu Gly Pro 
    2525                 2530                 2535             


Leu Ser  Ile Asp Pro Asn Met  Leu Asn Ala Gln Lys  Gln Gln Val 
    2540                 2545                 2550             


Gln Phe  Met Leu Lys Glu Phe  Glu Ala Arg Arg Gln  Gln His Glu 
    2555                 2560                 2565             


Gln Leu  Asn Glu Ala Ala Gln  Gly Ile Leu Thr Gly  Pro Gly Asp 
    2570                 2575                 2580             


Val Ser  Leu Ser Thr Ser Gln  Val Gln Lys Glu Leu  Gln Ser Ile 
    2585                 2590                 2595             


Asn Gln  Lys Trp Val Glu Leu  Thr Asp Lys Leu Asn  Ser Arg Ser 
    2600                 2605                 2610             


Ser Gln  Ile Asp Gln Ala Ile  Val Lys Ser Thr Gln  Tyr Gln Glu 
    2615                 2620                 2625             


Leu Leu  Gln Asp Leu Ser Glu  Lys Val Arg Ala Val  Gly Gln Arg 
    2630                 2635                 2640             


Leu Ser  Val Gln Ser Ala Ile  Ser Thr Gln Pro Glu  Ala Val Lys 
    2645                 2650                 2655             


Gln Gln  Leu Glu Glu Thr Ser  Glu Ile Arg Ser Asp  Leu Glu Gln 
    2660                 2665                 2670             


Leu Asp  His Glu Val Lys Glu  Ala Gln Thr Leu Cys  Asp Glu Leu 
    2675                 2680                 2685             


Ser Val  Leu Ile Gly Glu Gln  Tyr Leu Lys Asp Glu  Leu Lys Lys 
    2690                 2695                 2700             


Arg Leu  Glu Thr Val Ala Leu  Pro Leu Gln Gly Leu  Glu Asp Leu 
    2705                 2710                 2715             


Ala Ala  Asp Arg Ile Asn Arg  Leu Gln Ala Ala Leu  Ala Ser Thr 
    2720                 2725                 2730             


Gln Gln  Phe Gln Gln Met Phe  Asp Glu Leu Arg Thr  Trp Leu Asp 
    2735                 2740                 2745             


Asp Lys  Gln Ser Gln Gln Ala  Lys Asn Cys Pro Ile  Ser Ala Lys 
    2750                 2755                 2760             


Leu Glu  Arg Leu Gln Ser Gln  Leu Gln Glu Asn Glu  Glu Phe Gln 
    2765                 2770                 2775             


Lys Ser  Leu Asn Gln His Ser  Gly Ser Tyr Glu Val  Ile Val Ala 
    2780                 2785                 2790             


Glu Gly  Glu Ser Leu Leu Leu  Ser Val Pro Pro Gly  Glu Glu Lys 
    2795                 2800                 2805             


Arg Thr  Leu Gln Asn Gln Leu  Val Glu Leu Lys Asn  His Trp Glu 
    2810                 2815                 2820             


Glu Leu  Ser Lys Lys Thr Ala  Asp Arg Gln Ser Arg  Leu Lys Asp 
    2825                 2830                 2835             


Cys Met  Gln Lys Ala Gln Lys  Tyr Gln Trp His Val  Glu Asp Leu 
    2840                 2845                 2850             


Val Pro  Trp Ile Glu Asp Cys  Lys Ala Lys Met Ser  Glu Leu Arg 
    2855                 2860                 2865             


Val Thr  Leu Asp Pro Val Gln  Leu Glu Ser Ser Leu  Leu Arg Ser 
    2870                 2875                 2880             


Lys Ala  Met Leu Asn Glu Val  Glu Lys Arg Arg Ser  Leu Leu Glu 
    2885                 2890                 2895             


Ile Leu  Asn Ser Ala Ala Asp  Ile Leu Ile Asn Ser  Ser Glu Ala 
    2900                 2905                 2910             


Asp Glu  Asp Gly Ile Arg Asp  Glu Lys Ala Gly Ile  Asn Gln Asn 
    2915                 2920                 2925             


Met Asp  Ala Val Thr Glu Glu  Leu Gln Ala Lys Thr  Gly Ser Leu 
    2930                 2935                 2940             


Glu Glu  Met Thr Gln Arg Leu  Arg Glu Phe Gln Glu  Ser Phe Lys 
    2945                 2950                 2955             


Asn Ile  Glu Lys Lys Val Glu  Gly Ala Lys His Gln  Leu Glu Ile 
    2960                 2965                 2970             


Phe Asp  Ala Leu Gly Ser Gln  Ala Cys Ser Asn Lys  Asn Leu Glu 
    2975                 2980                 2985             


Lys Leu  Arg Ala Gln Gln Glu  Val Leu Gln Ala Leu  Glu Pro Gln 
    2990                 2995                 3000             


Val Asp  Tyr Leu Arg Asn Phe  Thr Gln Gly Leu Val  Glu Asp Ala 
    3005                 3010                 3015             


Pro Asp  Gly Ser Asp Ala Ser  Gln Leu Leu His Gln  Ala Glu Val 
    3020                 3025                 3030             


Ala Gln  Gln Glu Phe Leu Glu  Val Lys Gln Arg Val  Asn Ser Gly 
    3035                 3040                 3045             


Cys Val  Met Met Glu Asn Lys  Leu Glu Gly Ile Gly  Gln Phe His 
    3050                 3055                 3060             


Cys Arg  Val Arg Glu Met Phe  Ser Gln Leu Ala Asp  Leu Asp Asp 
    3065                 3070                 3075             


Glu Leu  Asp Gly Met Gly Ala  Ile Gly Arg Asp Thr  Asp Ser Leu 
    3080                 3085                 3090             


Gln Ser  Gln Ile Glu Asp Val  Arg Leu Phe Leu Asn  Lys Ile His 
    3095                 3100                 3105             


Val Leu  Lys Leu Asp Ile Glu  Ala Ser Glu Ala Glu  Cys Arg His 
    3110                 3115                 3120             


Met Leu  Glu Glu Glu Gly Thr  Leu Asp Leu Leu Gly  Leu Lys Arg 
    3125                 3130                 3135             


Glu Leu  Glu Ala Leu Asn Lys  Gln Cys Gly Lys Leu  Thr Glu Arg 
    3140                 3145                 3150             


Gly Lys  Ala Arg Gln Glu Gln  Leu Glu Leu Thr Leu  Gly Arg Val 
    3155                 3160                 3165             


Glu Asp  Phe Tyr Arg Lys Leu  Lys Gly Leu Asn Asp  Ala Thr Thr 
    3170                 3175                 3180             


Ala Ala  Glu Glu Ala Glu Ala  Leu Gln Trp Val Val  Gly Thr Glu 
    3185                 3190                 3195             


Val Glu  Ile Ile Asn Gln Gln  Leu Ala Asp Phe Lys  Met Phe Gln 
    3200                 3205                 3210             


Lys Glu  Gln Val Asp Pro Leu  Gln Met Lys Leu Gln  Gln Val Asn 
    3215                 3220                 3225             


Gly Leu  Gly Gln Gly Leu Ile  Gln Ser Ala Gly Lys  Asp Cys Asp 
    3230                 3235                 3240             


Val Gln  Gly Leu Glu His Asp  Met Glu Glu Ile Asn  Ala Arg Trp 
    3245                 3250                 3255             


Asn Thr  Leu Asn Lys Lys Val  Ala Gln Arg Ile Ala  Gln Leu Gln 
    3260                 3265                 3270             


Glu Ala  Leu Leu His Cys Gly  Lys Phe Gln Asp Ala  Leu Glu Pro 
    3275                 3280                 3285             


Leu Leu  Ser Trp Leu Ala Asp  Thr Glu Glu Leu Ile  Ala Asn Gln 
    3290                 3295                 3300             


Lys Pro  Pro Ser Ala Glu Tyr  Lys Val Val Lys Ala  Gln Ile Gln 
    3305                 3310                 3315             


Glu Gln  Lys Leu Leu Gln Arg  Leu Leu Asp Asp Arg  Lys Ala Thr 
    3320                 3325                 3330             


Val Asp  Met Leu Gln Ala Glu  Gly Gly Arg Ile Ala  Gln Ser Ala 
    3335                 3340                 3345             


Glu Leu  Ala Asp Arg Glu Lys  Ile Thr Gly Gln Leu  Glu Ser Leu 
    3350                 3355                 3360             


Glu Ser  Arg Trp Thr Glu Leu  Leu Ser Lys Ala Ala  Ala Arg Gln 
    3365                 3370                 3375             


Lys Gln  Leu Glu Asp Ile Leu  Val Leu Ala Lys Gln  Phe His Glu 
    3380                 3385                 3390             


Thr Ala  Glu Pro Ile Ser Asp  Phe Leu Ser Val Thr  Glu Lys Lys 
    3395                 3400                 3405             


Leu Ala  Asn Ser Glu Pro Val  Gly Thr Gln Thr Ala  Lys Ile Gln 
    3410                 3415                 3420             


Gln Gln  Ile Ile Arg His Lys  Ala Leu Glu Glu Asp  Ile Glu Asn 
    3425                 3430                 3435             


His Ala  Thr Asp Val His Gln  Ala Val Lys Ile Gly  Gln Ser Leu 
    3440                 3445                 3450             


Ser Ser  Leu Thr Ser Pro Ala  Glu Gln Gly Val Leu  Ser Glu Lys 
    3455                 3460                 3465             


Ile Asp  Ser Leu Gln Ala Arg  Tyr Ser Glu Ile Gln  Asp Arg Cys 
    3470                 3475                 3480             


Cys Arg  Lys Ala Ala Leu Leu  Asp Gln Ala Leu Ser  Asn Ala Arg 
    3485                 3490                 3495             


Leu Phe  Gly Glu Asp Glu Val  Glu Val Leu Asn Trp  Leu Ala Glu 
    3500                 3505                 3510             


Val Glu  Asp Lys Leu Ser Ser  Val Phe Val Lys Asp  Phe Lys Gln 
    3515                 3520                 3525             


Asp Val  Leu His Arg Gln His  Ala Asp His Leu Ala  Leu Asn Glu 
    3530                 3535                 3540             


Glu Ile  Val Asn Arg Lys Lys  Asn Val Asp Gln Ala  Ile Lys Asn 
    3545                 3550                 3555             


Gly Gln  Ala Leu Leu Lys Gln  Thr Thr Gly Glu Glu  Val Leu Leu 
    3560                 3565                 3570             


Ile Gln  Glu Lys Leu Asp Gly  Ile Lys Thr Arg Tyr  Ala Asp Ile 
    3575                 3580                 3585             


Thr Val  Thr Ser Ser Lys Ala  Leu Arg Thr Leu Glu  Gln Ala Arg 
    3590                 3595                 3600             


Gln Leu  Ala Thr Lys Phe Gln  Ser Thr Tyr Glu Glu  Leu Thr Gly 
    3605                 3610                 3615             


Trp Leu  Arg Glu Val Glu Glu  Glu Leu Ala Thr Ser  Gly Gly Gln 
    3620                 3625                 3630             


Ser Pro  Thr Gly Glu Gln Ile  Pro Gln Phe Gln Gln  Arg Gln Lys 
    3635                 3640                 3645             


Glu Leu  Lys Lys Glu Val Met  Glu His Arg Leu Val  Leu Asp Thr 
    3650                 3655                 3660             


Val Asn  Glu Val Ser Arg Ala  Leu Leu Glu Leu Val  Pro Trp Arg 
    3665                 3670                 3675             


Ala Arg  Glu Gly Leu Asp Lys  Leu Val Ser Asp Ala  Asn Glu Gln 
    3680                 3685                 3690             


Tyr Lys  Leu Val Ser Asp Thr  Ile Gly Gln Arg Val  Asp Glu Ile 
    3695                 3700                 3705             


Asp Ala  Ala Ile Gln Arg Ser  Gln Gln Tyr Glu Gln  Ala Ala Asp 
    3710                 3715                 3720             


Ala Glu  Leu Ala Trp Val Ala  Glu Thr Lys Arg Lys  Leu Met Ala 
    3725                 3730                 3735             


Leu Gly  Pro Ile Arg Leu Glu  Gln Asp Gln Thr Thr  Ala Gln Leu 
    3740                 3745                 3750             


Gln Val  Gln Lys Ala Phe Ser  Ile Asp Ile Ile Arg  His Lys Asp 
    3755                 3760                 3765             


Ser Met  Asp Glu Leu Phe Ser  His Arg Ser Glu Ile  Phe Gly Thr 
    3770                 3775                 3780             


Cys Gly  Glu Glu Gln Lys Thr  Val Leu Gln Glu Lys  Thr Glu Ser 
    3785                 3790                 3795             


Leu Ile  Gln Gln Tyr Glu Ala  Ile Ser Leu Leu Asn  Ser Glu Arg 
    3800                 3805                 3810             


Tyr Ala  Arg Leu Glu Arg Ala  Gln Val Leu Val Asn  Gln Phe Trp 
    3815                 3820                 3825             


Glu Thr  Tyr Glu Glu Leu Ser  Pro Trp Ile Glu Glu  Thr Arg Ala 
    3830                 3835                 3840             


Leu Ile  Ala Gln Leu Pro Ser  Pro Ala Ile Asp His  Glu Gln Leu 
    3845                 3850                 3855             


Arg Gln  Gln Gln Glu Glu Met  Arg Gln Leu Arg Glu  Ser Ile Ala 
    3860                 3865                 3870             


Glu His  Lys Pro His Ile Asp  Lys Leu Leu Lys Ile  Gly Pro Gln 
    3875                 3880                 3885             


Leu Lys  Glu Leu Asn Pro Glu  Glu Gly Glu Met Val  Glu Glu Lys 
    3890                 3895                 3900             


Tyr Gln  Lys Ala Glu Asn Met  Tyr Ala Gln Ile Lys  Glu Glu Val 
    3905                 3910                 3915             


Arg Gln  Arg Ala Leu Ala Leu  Asp Glu Ala Val Ser  Gln Ser Thr 
    3920                 3925                 3930             


Gln Ile  Thr Glu Phe His Asp  Lys Ile Glu Pro Met  Leu Glu Thr 
    3935                 3940                 3945             


Leu Glu  Asn Leu Ser Ser Arg  Leu Arg Met Pro Pro  Leu Ile Pro 
    3950                 3955                 3960             


Ala Glu  Val Asp Lys Ile Arg  Glu Cys Ile Ser Asp  Asn Lys Ser 
    3965                 3970                 3975             


Ala Thr  Val Glu Leu Glu Lys  Leu Gln Pro Ser Phe  Glu Ala Leu 
    3980                 3985                 3990             


Lys Arg  Arg Gly Glu Glu Leu  Ile Gly Arg Ser Gln  Gly Ala Asp 
    3995                 4000                 4005             


Lys Asp  Leu Ala Ala Lys Glu  Ile Gln Asp Lys Leu  Asp Gln Met 
    4010                 4015                 4020             


Val Phe  Phe Trp Glu Asp Ile  Lys Ala Arg Ala Glu  Glu Arg Glu 
    4025                 4030                 4035             


Ile Lys  Phe Leu Asp Val Leu  Glu Leu Ala Glu Lys  Phe Trp Tyr 
    4040                 4045                 4050             


Asp Met  Ala Ala Leu Leu Thr  Thr Ile Lys Asp Thr  Gln Asp Ile 
    4055                 4060                 4065             


Val His  Asp Leu Glu Ser Pro  Gly Ile Asp Pro Ser  Ile Ile Lys 
    4070                 4075                 4080             


Gln Gln  Val Glu Ala Ala Glu  Thr Ile Lys Glu Glu  Thr Asp Gly 
    4085                 4090                 4095             


Leu His  Glu Glu Leu Glu Phe  Ile Arg Ile Leu Gly  Ala Asp Leu 
    4100                 4105                 4110             


Ile Phe  Ala Cys Gly Glu Thr  Glu Lys Pro Glu Val  Arg Lys Ser 
    4115                 4120                 4125             


Ile Asp  Glu Met Asn Asn Ala  Trp Glu Asn Leu Asn  Lys Thr Trp 
    4130                 4135                 4140             


Lys Glu  Arg Leu Glu Lys Leu  Glu Asp Ala Met Gln  Ala Ala Val 
    4145                 4150                 4155             


Gln Tyr  Gln Asp Thr Leu Gln  Ala Met Phe Asp Trp  Leu Asp Asn 
    4160                 4165                 4170             


Thr Val  Ile Lys Leu Cys Thr  Met Pro Pro Val Gly  Thr Asp Leu 
    4175                 4180                 4185             


Asn Thr  Val Lys Asp Gln Leu  Asn Glu Met Lys Glu  Phe Lys Val 
    4190                 4195                 4200             


Glu Val  Tyr Gln Gln Gln Ile  Glu Met Glu Lys Leu  Asn His Gln 
    4205                 4210                 4215             


Gly Glu  Leu Met Leu Lys Lys  Ala Thr Asp Glu Thr  Asp Arg Asp 
    4220                 4225                 4230             


Ile Ile  Arg Glu Pro Leu Thr  Glu Leu Lys His Leu  Trp Glu Asn 
    4235                 4240                 4245             


Leu Gly  Glu Lys Ile Ala His  Arg Gln His Lys Leu  Glu Gly Ala 
    4250                 4255                 4260             


Leu Leu  Ala Leu Gly Gln Phe  Gln His Ala Leu Glu  Glu Leu Met 
    4265                 4270                 4275             


Ser Trp  Leu Thr His Thr Glu  Glu Leu Leu Asp Ala  Gln Arg Pro 
    4280                 4285                 4290             


Ile Ser  Gly Asp Pro Lys Val  Ile Glu Val Glu Leu  Ala Lys His 
    4295                 4300                 4305             


His Val  Leu Lys Asn Asp Val  Leu Ala His Gln Ala  Thr Val Glu 
    4310                 4315                 4320             


Thr Val  Asn Lys Ala Gly Asn  Glu Leu Leu Glu Ser  Ser Ala Gly 
    4325                 4330                 4335             


Asp Asp  Ala Ser Ser Leu Arg  Ser Arg Leu Glu Ala  Met Asn Gln 
    4340                 4345                 4350             


Cys Trp  Glu Ser Val Leu Gln  Lys Thr Glu Glu Arg  Glu Gln Gln 
    4355                 4360                 4365             


Leu Gln  Ser Thr Leu Gln Gln  Ala Gln Gly Phe His  Ser Glu Ile 
    4370                 4375                 4380             


Glu Asp  Phe Leu Leu Glu Leu  Thr Arg Met Glu Ser  Gln Leu Ser 
    4385                 4390                 4395             


Ala Ser  Lys Pro Thr Gly Gly  Leu Pro Glu Thr Ala  Arg Glu Gln 
    4400                 4405                 4410             


Leu Asp  Thr His Met Glu Leu  Tyr Ser Gln Leu Lys  Ala Lys Glu 
    4415                 4420                 4425             


Glu Thr  Tyr Asn Gln Leu Leu  Asp Lys Gly Arg Leu  Met Leu Leu 
    4430                 4435                 4440             


Ser Arg  Asp Asp Ser Gly Ser  Gly Ser Lys Thr Glu  Gln Ser Val 
    4445                 4450                 4455             


Ala Leu  Leu Glu Gln Lys Trp  His Val Val Ser Ser  Lys Met Glu 
    4460                 4465                 4470             


Glu Arg  Lys Ser Lys Leu Glu  Glu Ala Leu Asn Leu  Ala Thr Glu 
    4475                 4480                 4485             


Phe Gln  Asn Ser Leu Gln Glu  Phe Ile Asn Trp Leu  Thr Leu Ala 
    4490                 4495                 4500             


Glu Gln  Ser Leu Asn Ile Ala  Ser Pro Pro Ser Leu  Ile Leu Asn 
    4505                 4510                 4515             


Thr Val  Leu Ser Gln Ile Glu  Glu His Lys Val Phe  Ala Asn Glu 
    4520                 4525                 4530             


Val Asn  Ala His Arg Asp Gln  Ile Ile Glu Leu Asp  Gln Thr Gly 
    4535                 4540                 4545             


Asn Gln  Leu Lys Phe Leu Ser  Gln Lys Gln Asp Val  Val Leu Ile 
    4550                 4555                 4560             


Lys Asn  Leu Leu Val Ser Val  Gln Ser Arg Trp Glu  Lys Val Val 
    4565                 4570                 4575             


Gln Arg  Ser Ile Glu Arg Gly  Arg Ser Leu Asp Asp  Ala Arg Lys 
    4580                 4585                 4590             


Arg Ala  Lys Gln Phe His Glu  Ala Trp Lys Lys Leu  Ile Asp Trp 
    4595                 4600                 4605             


Leu Glu  Asp Ala Glu Ser His  Leu Asp Ser Glu Leu  Glu Ile Ser 
    4610                 4615                 4620             


Asn Asp  Pro Asp Lys Ile Lys  Leu Gln Leu Ser Lys  His Lys Glu 
    4625                 4630                 4635             


Phe Gln  Lys Thr Leu Gly Gly  Lys Gln Pro Val Tyr  Asp Thr Thr 
    4640                 4645                 4650             


Ile Arg  Thr Gly Arg Ala Leu  Lys Glu Lys Thr Leu  Leu Pro Glu 
    4655                 4660                 4665             


Asp Ser  Gln Lys Leu Asp Asn  Phe Leu Gly Glu Val  Arg Asp Lys 
    4670                 4675                 4680             


Trp Asp  Thr Val Cys Gly Lys  Ser Val Glu Arg Gln  His Lys Leu 
    4685                 4690                 4695             


Glu Glu  Ala Leu Leu Phe Ser  Gly Gln Phe Met Asp  Ala Leu Gln 
    4700                 4705                 4710             


Ala Leu  Val Asp Trp Leu Tyr  Lys Val Glu Pro Gln  Leu Ala Glu 
    4715                 4720                 4725             


Asp Gln  Pro Val His Gly Asp  Leu Asp Leu Val Met  Asn Leu Met 
    4730                 4735                 4740             


Asp Ala  His Lys Val Phe Gln  Lys Glu Leu Gly Lys  Arg Thr Gly 
    4745                 4750                 4755             


Thr Val  Gln Val Leu Lys Arg  Ser Gly Arg Glu Leu  Ile Glu Asn 
    4760                 4765                 4770             


Ser Arg  Asp Asp Thr Thr Trp  Val Lys Gly Gln Leu  Gln Glu Leu 
    4775                 4780                 4785             


Ser Thr  Arg Trp Asp Thr Val  Cys Lys Leu Ser Val  Ser Lys Gln 
    4790                 4795                 4800             


Ser Arg  Leu Glu Gln Ala Leu  Lys Gln Ala Glu Val  Phe Arg Asp 
    4805                 4810                 4815             


Thr Val  His Met Leu Leu Glu  Trp Leu Ser Glu Ala  Glu Gln Thr 
    4820                 4825                 4830             


Leu Arg  Phe Arg Gly Ala Leu  Pro Asp Asp Thr Glu  Ala Leu Gln 
    4835                 4840                 4845             


Ser Leu  Ile Asp Thr His Lys  Glu Phe Met Lys Lys  Val Glu Glu 
    4850                 4855                 4860             


Lys Arg  Val Asp Val Asn Ser  Ala Val Ala Met Gly  Glu Val Ile 
    4865                 4870                 4875             


Leu Ala  Val Cys His Pro Asp  Cys Ile Thr Thr Ile  Lys His Trp 
    4880                 4885                 4890             


Ile Thr  Ile Ile Arg Ala Arg  Phe Glu Glu Val Leu  Thr Trp Ala 
    4895                 4900                 4905             


Lys Gln  His Gln Gln Arg Leu  Glu Thr Ala Leu Ser  Glu Leu Val 
    4910                 4915                 4920             


Ala Asn  Ala Glu Leu Leu Glu  Glu Leu Leu Ala Trp  Ile Gln Trp 
    4925                 4930                 4935             


Ala Glu  Thr Thr Leu Ile Gln  Arg Asp Gln Glu Pro  Ile Pro Gln 
    4940                 4945                 4950             


Asn Ile  Asp Arg Val Lys Ala  Leu Ile Ala Glu His  Gln Thr Phe 
    4955                 4960                 4965             


Met Glu  Glu Met Thr Arg Lys  Gln Pro Asp Val Asp  Arg Val Thr 
    4970                 4975                 4980             


Lys Thr  Tyr Lys Arg Lys Asn  Ile Glu Pro Thr His  Ala Pro Phe 
    4985                 4990                 4995             


Ile Glu  Lys Ser Arg Ser Gly  Gly Arg Lys Ser Leu  Ser Gln Pro 
    5000                 5005                 5010             


Thr Pro  Pro Pro Met Pro Ile  Leu Ser Gln Ser Glu  Ala Lys Asn 
    5015                 5020                 5025             


Pro Arg  Ile Asn Gln Leu Ser  Ala Arg Trp Gln Gln  Val Trp Leu 
    5030                 5035                 5040             


Leu Ala  Leu Glu Arg Gln Arg  Lys Leu Asn Asp Ala  Leu Asp Arg 
    5045                 5050                 5055             


Leu Glu  Glu Leu Lys Glu Phe  Ala Asn Phe Asp Phe  Asp Val Trp 
    5060                 5065                 5070             


Arg Lys  Lys Tyr Met Arg Trp  Met Asn His Lys Lys  Ser Arg Val 
    5075                 5080                 5085             


Met Asp  Phe Phe Arg Arg Ile  Asp Lys Asp Gln Asp  Gly Lys Ile 
    5090                 5095                 5100             


Thr Arg  Gln Glu Phe Ile Asp  Gly Ile Leu Ala Ser  Lys Phe Pro 
    5105                 5110                 5115             


Thr Thr  Lys Leu Glu Met Thr  Ala Val Ala Asp Ile  Phe Asp Arg 
    5120                 5125                 5130             


Asp Gly  Asp Gly Tyr Ile Asp  Tyr Tyr Glu Phe Val  Ala Ala Leu 
    5135                 5140                 5145             


His Pro  Asn Lys Asp Ala Tyr  Arg Pro Thr Thr Asp  Ala Asp Lys 
    5150                 5155                 5160             


Ile Glu  Asp Glu Val Thr Arg  Gln Val Ala Gln Cys  Lys Cys Ala 
    5165                 5170                 5175             


Lys Arg  Phe Gln Val Glu Gln  Ile Gly Glu Asn Lys  Tyr Arg Phe 
    5180                 5185                 5190             


Gly Asp  Ser Gln Gln Leu Arg  Leu Val Arg Ile Leu  Arg Ser Thr 
    5195                 5200                 5205             


Val Met  Val Arg Val Gly Gly  Gly Trp Met Ala Leu  Asp Glu Phe 
    5210                 5215                 5220             


Leu Val  Lys Asn Asp Pro Cys  Arg Ala Arg Gly Arg  Thr Asn Ile 
    5225                 5230                 5235             


Glu Leu  Arg Glu Lys Phe Ile  Leu Pro Glu Gly Ala  Ser Gln Gly 
    5240                 5245                 5250             


Met Thr  Pro Phe Arg Ser Arg  Gly Arg Arg Ser Lys  Pro Ser Ser 
    5255                 5260                 5265             


Arg Ala  Ala Ser Pro Thr Arg  Ser Ser Ser Ser Ala  Ser Gln Ser 
    5270                 5275                 5280             


Asn His  Ser Cys Thr Ser Met  Pro Ser Ser Pro Ala  Thr Pro Ala 
    5285                 5290                 5295             


Ser Gly  Thr Lys Val Ile Pro  Ser Ser Gly Ser Lys  Leu Lys Arg 
    5300                 5305                 5310             


Pro Thr  Pro Thr Phe His Ser  Ser Arg Thr Ser Leu  Ala Gly Asp 
    5315                 5320                 5325             


Thr Ser  Asn Ser Ser Ser Pro  Ala Ser Thr Gly Ala  Lys Thr Asn 
    5330                 5335                 5340             


Arg Ala  Asp Pro Lys Lys Ser  Ala Ser Arg Pro Gly  Ser Arg Ala 
    5345                 5350                 5355             


Gly Ser  Arg Ala Gly Ser Arg  Ala Ser Ser Arg Arg  Gly Ser Asp 
    5360                 5365                 5370             


Ala Ser  Asp Phe Asp Leu Leu  Glu Thr Gln Ser Ala  Cys Ser Asp 
    5375                 5380                 5385             


Thr Ser  Glu Ser Ser Ala Ala  Gly Gly Gln Gly Asn  Ser Arg Arg 
    5390                 5395                 5400             


Gly Leu  Asn Lys Pro Ser Lys  Ile Pro Thr Met Ser  Lys Lys Thr 
    5405                 5410                 5415             


Thr Thr  Ala Ser Pro Arg Thr  Pro Gly Pro Lys Arg  
    5420                 5425                 5430 


<210>  5442
<211>  512
<212>  PRT
<213>  Homo sapiens

<400>  5442

Met Lys Ala Ile Ile His Leu Thr Leu Leu Ala Leu Leu Ser Val Asn 
1               5                   10                  15      


Thr Ala Thr Asn Gln Gly Asn Ser Ala Asp Ala Val Thr Thr Thr Glu 
            20                  25                  30          


Thr Ala Thr Ser Gly Pro Thr Val Ala Ala Ala Asp Thr Thr Glu Thr 
        35                  40                  45              


Asn Phe Pro Glu Thr Ala Ser Thr Thr Ala Asn Thr Pro Ser Phe Pro 
    50                  55                  60                  


Thr Ala Thr Ser Pro Ala Pro Pro Ile Ile Ser Thr His Ser Ser Ser 
65                  70                  75                  80  


Thr Ile Pro Thr Pro Ala Pro Pro Ile Ile Ser Thr His Ser Ser Ser 
                85                  90                  95      


Thr Ile Pro Ile Pro Thr Ala Ala Asp Ser Glu Ser Thr Thr Asn Val 
            100                 105                 110         


Asn Ser Leu Ala Thr Ser Asp Ile Ile Thr Ala Ser Ser Pro Asn Asp 
        115                 120                 125             


Gly Leu Ile Thr Met Val Pro Ser Glu Thr Gln Ser Asn Asn Glu Met 
    130                 135                 140                 


Ser Pro Thr Thr Glu Asp Asn Gln Ser Ser Gly Pro Pro Thr Gly Thr 
145                 150                 155                 160 


Ala Leu Leu Glu Thr Ser Thr Leu Asn Ser Thr Gly Pro Ser Asn Pro 
                165                 170                 175     


Cys Gln Asp Asp Pro Cys Ala Asp Asn Ser Leu Cys Val Lys Leu His 
            180                 185                 190         


Asn Thr Ser Phe Cys Leu Cys Leu Glu Gly Tyr Tyr Tyr Asn Ser Ser 
        195                 200                 205             


Thr Cys Lys Lys Gly Lys Val Phe Pro Gly Lys Ile Ser Val Thr Val 
    210                 215                 220                 


Ser Glu Thr Phe Asp Pro Glu Glu Lys His Ser Met Ala Tyr Gln Asp 
225                 230                 235                 240 


Leu His Ser Glu Ile Thr Ser Leu Phe Lys Asp Val Phe Gly Thr Ser 
                245                 250                 255     


Val Tyr Gly Gln Thr Val Ile Leu Thr Val Ser Thr Ser Leu Ser Pro 
            260                 265                 270         


Arg Ser Glu Met Arg Ala Asp Asp Lys Phe Val Asn Val Thr Ile Val 
        275                 280                 285             


Thr Ile Leu Ala Glu Thr Thr Ser Asp Asn Glu Lys Thr Val Thr Glu 
    290                 295                 300                 


Lys Ile Asn Lys Ala Ile Arg Ser Ser Ser Ser Asn Phe Leu Asn Tyr 
305                 310                 315                 320 


Asp Leu Thr Leu Arg Cys Asp Tyr Tyr Gly Cys Asn Gln Thr Ala Asp 
                325                 330                 335     


Asp Cys Leu Asn Gly Leu Ala Cys Asp Cys Lys Ser Asp Leu Gln Arg 
            340                 345                 350         


Pro Asn Pro Gln Ser Pro Phe Cys Val Ala Ser Ser Leu Lys Cys Pro 
        355                 360                 365             


Asp Ala Cys Asn Ala Gln His Lys Gln Cys Leu Ile Lys Lys Ser Gly 
    370                 375                 380                 


Gly Ala Pro Glu Cys Ala Cys Val Pro Gly Tyr Gln Glu Asp Ala Asn 
385                 390                 395                 400 


Gly Asn Cys Gln Lys Cys Ala Phe Gly Tyr Ser Gly Leu Asp Cys Lys 
                405                 410                 415     


Asp Lys Phe Gln Leu Ile Leu Thr Ile Val Gly Thr Ile Ala Gly Ile 
            420                 425                 430         


Val Ile Leu Ser Met Ile Ile Ala Leu Ile Val Thr Ala Arg Ser Asn 
        435                 440                 445             


Asn Lys Thr Lys His Ile Glu Glu Glu Asn Leu Ile Asp Glu Asp Phe 
    450                 455                 460                 


Gln Asn Leu Lys Leu Arg Ser Thr Gly Phe Thr Asn Leu Gly Ala Glu 
465                 470                 475                 480 


Gly Ser Val Phe Pro Lys Val Arg Ile Thr Ala Ser Arg Asp Ser Gln 
                485                 490                 495     


Met Gln Asn Pro Tyr Ser Arg His Ser Ser Met Pro Arg Pro Asp Tyr 
            500                 505                 510         


<210>  5443
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  5443

Met Leu Gly Ile Met Ala Trp Asn Ala Thr Cys Lys Asn Trp Leu Ala 
1               5                   10                  15      


Ala Glu Ala Ala Leu Glu Lys Tyr Tyr Leu Ser Ile Phe Tyr Gly Ile 
            20                  25                  30          


Glu Phe Val Val Gly Val Leu Gly Asn Thr Ile Val Val Tyr Gly Tyr 
        35                  40                  45              


Ile Phe Ser Leu Lys Asn Trp Asn Ser Ser Asn Ile Tyr Leu Phe Asn 
    50                  55                  60                  


Leu Ser Val Ser Asp Leu Ala Phe Leu Cys Thr Leu Pro Met Leu Ile 
65                  70                  75                  80  


Arg Ser Tyr Ala Asn Gly Asn Trp Ile Tyr Gly Asp Val Leu Cys Ile 
                85                  90                  95      


Ser Asn Arg Tyr Val Leu His Ala Asn Leu Tyr Thr Ser Ile Leu Phe 
            100                 105                 110         


Leu Thr Phe Ile Ser Ile Asp Arg Tyr Leu Ile Ile Lys Tyr Pro Phe 
        115                 120                 125             


Arg Glu His Leu Leu Gln Lys Lys Glu Phe Ala Ile Leu Ile Ser Leu 
    130                 135                 140                 


Ala Ile Trp Val Leu Val Thr Leu Glu Leu Leu Pro Ile Leu Pro Leu 
145                 150                 155                 160 


Ile Asn Pro Val Ile Thr Asp Asn Gly Thr Thr Cys Asn Asp Phe Ala 
                165                 170                 175     


Ser Ser Gly Asp Pro Asn Tyr Asn Leu Ile Tyr Ser Met Cys Leu Thr 
            180                 185                 190         


Leu Leu Gly Phe Leu Ile Pro Leu Phe Val Met Cys Phe Phe Tyr Tyr 
        195                 200                 205             


Lys Ile Ala Leu Phe Leu Lys Gln Arg Asn Arg Gln Val Ala Thr Ala 
    210                 215                 220                 


Leu Pro Leu Glu Lys Pro Leu Asn Leu Val Ile Met Ala Val Val Ile 
225                 230                 235                 240 


Phe Ser Val Leu Phe Thr Pro Tyr His Val Met Arg Asn Val Arg Ile 
                245                 250                 255     


Ala Ser Arg Leu Gly Ser Trp Lys Gln Tyr Gln Cys Thr Gln Val Val 
            260                 265                 270         


Ile Asn Ser Phe Tyr Ile Val Thr Arg Pro Leu Ala Phe Leu Asn Ser 
        275                 280                 285             


Val Ile Asn Pro Val Phe Tyr Phe Leu Leu Gly Asp His Phe Arg Asp 
    290                 295                 300                 


Met Leu Met Asn Gln Leu Arg His Asn Phe Lys Ser Leu Thr Ser Phe 
305                 310                 315                 320 


Ser Arg Trp Ala His Glu Leu Leu Leu Ser Phe Arg Glu Lys 
                325                 330                 


<210>  5444
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  5444

Met Ser Pro Glu Val Thr Cys Pro Arg Arg Gly His Leu Pro Arg Phe 
1               5                   10                  15      


His Pro Arg Thr Trp Val Glu Pro Val Val Ala Ser Ser Gln Val Ala 
            20                  25                  30          


Ala Ser Leu Tyr Asp Ala Gly Leu Leu Leu Val Val Lys Ala Ser Tyr 
        35                  40                  45              


Gly Thr Gly Gly Ser Ser Asn His Ser Ala Ser Pro Ser Pro Arg Gly 
    50                  55                  60                  


Ala Leu Glu Asp Gln Gln Gln Arg Ala Ile Ser Asn Phe Tyr Ile Ile 
65                  70                  75                  80  


Tyr Asn Leu Val Val Gly Leu Ser Pro Leu Leu Ser Ala Tyr Gly Leu 
                85                  90                  95      


Gly Trp Leu Ser Asp Arg Tyr His Arg Lys Ile Ser Ile Cys Met Ser 
            100                 105                 110         


Leu Leu Gly Phe Leu Leu Ser Arg Leu Gly Leu Leu Leu Lys Val Leu 
        115                 120                 125             


Leu Asp Trp Pro Val Glu Val Leu Tyr Gly Ala Ala Ala Leu Asn Gly 
    130                 135                 140                 


Leu Phe Gly Gly Phe Ser Ala Phe Trp Ser Gly Val Met Ala Leu Gly 
145                 150                 155                 160 


Ser Leu Gly Ser Ser Glu Gly Arg Arg Ser Val Arg Leu Ile Leu Ile 
                165                 170                 175     


Asp Leu Met Leu Gly Leu Ala Gly Phe Cys Gly Ser Met Ala Ser Gly 
            180                 185                 190         


His Leu Phe Lys Gln Met Ala Gly His Ser Gly Gln Gly Leu Ile Leu 
        195                 200                 205             


Thr Ala Cys Ser Val Ser Cys Ala Ser Phe Ala Leu Leu Tyr Ser Leu 
    210                 215                 220                 


Leu Val Leu Lys Val Pro Glu Ser Val Ala Lys Pro Ser Gln Glu Leu 
225                 230                 235                 240 


Pro Ala Val Asp Thr Val Ser Gly Thr Val Gly Thr Tyr Arg Thr Leu 
                245                 250                 255     


Asp Pro Asp Gln Leu Asp Gln Gln Tyr Ala Val Gly His Pro Pro Ser 
            260                 265                 270         


Pro Gly Lys Ala Lys Pro His Lys Thr Thr Ile Ala Leu Leu Phe Val 
        275                 280                 285             


Gly Ala Ile Ile Tyr Asp Leu Ala Val Val Gly Thr Val Asp Val Ile 
    290                 295                 300                 


Pro Leu Phe Val Leu Arg Glu Pro Leu Gly Trp Asn Gln Val Gln Val 
305                 310                 315                 320 


Gly Tyr Gly Met Ala Ala Gly Tyr Thr Ile Phe Ile Thr Ser Phe Leu 
                325                 330                 335     


Gly Val Leu Val Phe Ser Arg Cys Phe Arg Asp Thr Thr Met Ile Met 
            340                 345                 350         


Ile Gly Met Val Ser Phe Gly Ser Gly Ala Leu Leu Leu Ala Phe Val 
        355                 360                 365             


Lys Glu Thr Tyr Met Phe Tyr Ile Ala Arg Ala Val Met Leu Phe Ala 
    370                 375                 380                 


Leu Ile Pro Val Thr Thr Ile Arg Ser Ala Met Ser Lys Leu Ile Lys 
385                 390                 395                 400 


Gly Ser Ser Tyr Gly Lys Val Phe Val Ile Leu Gln Leu Ser Leu Ala 
                405                 410                 415     


Leu Thr Gly Val Val Thr Ser Thr Leu Tyr Asn Lys Ile Tyr Gln Leu 
            420                 425                 430         


Thr Met Asp Met Phe Val Gly Ser Cys Phe Ala Leu Ser Ser Phe Leu 
        435                 440                 445             


Ser Phe Leu Ala Ile Ile Pro Ile Ser Ile Val Ala Tyr Lys Gln Val 
    450                 455                 460                 


Pro Leu Ser Pro Tyr Gly Asp Ile Ile Glu Lys 
465                 470                 475 


<210>  5445
<211>  1955
<212>  PRT
<213>  Homo sapiens

<400>  5445

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Cys 
            20                  25                  30          


Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu 
        35                  40                  45              


Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly 
    50                  55                  60                  


Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn 
65                  70                  75                  80  


Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln Met Leu Phe Leu 
                85                  90                  95      


Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro Pro Met Asn Ile His 
            100                 105                 110         


Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys Lys Val Gly Thr Ile 
        115                 120                 125             


Ile Tyr His Glu Val Arg Ile Val Val Arg Asp Arg Asn Asp Asn Ser 
    130                 135                 140                 


Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr 
145                 150                 155                 160 


Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala 
                165                 170                 175     


Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln 
            180                 185                 190         


Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu 
        195                 200                 205             


Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp 
    210                 215                 220                 


Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn 
225                 230                 235                 240 


Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu Thr Val Asp Val Leu 
                245                 250                 255     


Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro Cys Val Leu Val Pro 
            260                 265                 270         


Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu 
        275                 280                 285             


Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile Val Thr Pro Pro Ile 
    290                 295                 300                 


Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro 
305                 310                 315                 320 


Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg 
                325                 330                 335     


Phe Phe His Met His Pro Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro 
            340                 345                 350         


Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu Val Ile Lys Ala Glu 
        355                 360                 365             


Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala Gly Leu His Ile Glu 
    370                 375                 380                 


Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr 
385                 390                 395                 400 


Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly Ala Thr Ile Ser Asp 
                405                 410                 415     


Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val Ala Leu Asp Lys Asp 
            420                 425                 430         


Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu Phe Leu Asn Asp Tyr 
        435                 440                 445             


Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr 
    450                 455                 460                 


Leu Leu Gln Pro Val Asp Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser 
465                 470                 475                 480 


Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu Pro Val Ile Val Asn 
                485                 490                 495     


Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile 
            500                 505                 510         


Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg Pro Gly Asp Ser Val 
        515                 520                 525             


Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile 
    530                 535                 540                 


Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys 
545                 550                 555                 560 


Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val Glu Met Ile Val Gly 
                565                 570                 575     


Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp Asn Ala Pro Pro Ala 
            580                 585                 590         


Glu Arg Arg Asn Ser Ile Cys Thr Val Tyr Ile Glu Val Leu Pro Pro 
        595                 600                 605             


Asn Asn Gln Ser Pro Pro Arg Phe Pro Gln Leu Met Tyr Ser Leu Glu 
    610                 615                 620                 


Ile Ser Glu Ala Met Arg Val Gly Ala Val Leu Leu Asn Leu Gln Ala 
625                 630                 635                 640 


Thr Asp Arg Glu Gly Asp Ser Ile Thr Tyr Ala Ile Glu Asn Gly Asp 
                645                 650                 655     


Pro Gln Arg Val Phe Asn Leu Ser Glu Thr Thr Gly Ile Leu Thr Leu 
            660                 665                 670         


Gly Lys Ala Leu Asp Arg Glu Ser Thr Asp Arg Tyr Ile Leu Ile Ile 
        675                 680                 685             


Thr Ala Ser Asp Gly Arg Pro Asp Gly Thr Ser Thr Ala Thr Val Asn 
    690                 695                 700                 


Ile Val Val Thr Asp Val Asn Asp Asn Ala Pro Val Phe Asp Pro Tyr 
705                 710                 715                 720 


Leu Pro Arg Asn Leu Ser Val Val Glu Glu Glu Ala Asn Ala Phe Val 
                725                 730                 735     


Gly Gln Val Lys Ala Thr Asp Pro Asp Ala Gly Ile Asn Gly Gln Val 
            740                 745                 750         


His Tyr Ser Leu Gly Asn Phe Asn Asn Leu Phe Arg Ile Thr Ser Asn 
        755                 760                 765             


Gly Ser Ile Tyr Thr Ala Val Lys Leu Asn Arg Glu Val Arg Asp Tyr 
    770                 775                 780                 


Tyr Glu Leu Val Val Val Ala Thr Asp Gly Ala Val His Pro Arg His 
785                 790                 795                 800 


Ser Thr Leu Thr Leu Ala Ile Lys Val Leu Asp Ile Asp Asp Asn Ser 
                805                 810                 815     


Pro Val Phe Thr Asn Ser Thr Tyr Thr Val Leu Val Glu Glu Asn Leu 
            820                 825                 830         


Pro Ala Gly Thr Thr Ile Leu Gln Ile Glu Ala Lys Asp Val Asp Leu 
        835                 840                 845             


Gly Ala Asn Val Ser Tyr Arg Ile Arg Ser Pro Glu Val Lys His Phe 
    850                 855                 860                 


Phe Ala Leu His Pro Phe Thr Gly Glu Leu Ser Leu Leu Arg Ser Leu 
865                 870                 875                 880 


Asp Tyr Glu Ala Phe Pro Asp Gln Glu Ala Ser Ile Thr Phe Leu Val 
                885                 890                 895     


Glu Ala Phe Asp Ile Tyr Gly Thr Met Pro Pro Gly Ile Ala Thr Val 
            900                 905                 910         


Thr Val Ile Val Lys Asp Met Asn Asp Tyr Pro Pro Val Phe Ser Lys 
        915                 920                 925             


Arg Ile Tyr Lys Gly Met Val Ala Pro Asp Ala Val Lys Gly Thr Pro 
    930                 935                 940                 


Ile Thr Thr Val Tyr Ala Glu Asp Ala Asp Pro Pro Gly Leu Pro Ala 
945                 950                 955                 960 


Ser Arg Val Arg Tyr Arg Val Asp Asp Val Gln Phe Pro Tyr Pro Ala 
                965                 970                 975     


Ser Ile Phe Glu Val Glu Glu Asp Ser Gly Arg Val Ile Thr Arg Val 
            980                 985                 990         


Asn Leu Asn Glu Glu Pro Thr Thr  Ile Phe Lys Leu Val  Val Val Ala 
        995                 1000                 1005             


Phe Asp  Asp Gly Glu Pro Val  Met Ser Ser Ser Ala  Thr Val Lys 
    1010                 1015                 1020             


Ile Leu  Val Leu His Pro Gly  Glu Ile Pro Arg Phe  Thr Gln Glu 
    1025                 1030                 1035             


Glu Tyr  Arg Pro Pro Pro Val  Ser Glu Leu Ala Thr  Lys Gly Thr 
    1040                 1045                 1050             


Met Val  Gly Val Ile Ser Ala  Ala Ala Ile Asn Gln  Ser Ile Val 
    1055                 1060                 1065             


Tyr Ser  Ile Val Ser Gly Asn  Glu Glu Asp Thr Phe  Gly Ile Asn 
    1070                 1075                 1080             


Asn Ile  Thr Gly Val Ile Tyr  Val Asn Gly Pro Leu  Asp Tyr Glu 
    1085                 1090                 1095             


Thr Arg  Thr Ser Tyr Val Leu  Arg Val Gln Ala Asp  Ser Leu Glu 
    1100                 1105                 1110             


Val Val  Leu Ala Asn Leu Arg  Val Pro Ser Lys Ser  Asn Thr Ala 
    1115                 1120                 1125             


Lys Val  Tyr Ile Glu Ile Gln  Asp Glu Asn Asn His  Pro Pro Val 
    1130                 1135                 1140             


Phe Gln  Lys Lys Phe Tyr Ile  Gly Gly Val Ser Glu  Asp Ala Arg 
    1145                 1150                 1155             


Met Phe  Thr Ser Val Leu Arg  Val Lys Ala Thr Asp  Lys Asp Thr 
    1160                 1165                 1170             


Gly Asn  Tyr Ser Val Met Ala  Tyr Arg Leu Ile Ile  Pro Pro Ile 
    1175                 1180                 1185             


Lys Glu  Gly Lys Glu Gly Phe  Val Val Glu Thr Tyr  Thr Gly Leu 
    1190                 1195                 1200             


Ile Lys  Thr Ala Met Leu Phe  His Asn Met Arg Arg  Ser Tyr Phe 
    1205                 1210                 1215             


Lys Phe  Gln Val Ile Ala Thr  Asp Asp Tyr Gly Lys  Gly Leu Ser 
    1220                 1225                 1230             


Gly Lys  Ala Asp Val Leu Val  Ser Val Val Asn Gln  Leu Asp Met 
    1235                 1240                 1245             


Gln Val  Ile Val Ser Asn Val  Pro Pro Thr Leu Val  Glu Lys Lys 
    1250                 1255                 1260             


Ile Glu  Asp Leu Thr Glu Ile  Leu Asp Arg Tyr Val  Gln Glu Gln 
    1265                 1270                 1275             


Ile Pro  Gly Ala Lys Val Val  Val Glu Ser Ile Gly  Ala Arg Arg 
    1280                 1285                 1290             


His Gly  Asp Ala Phe Ser Leu  Glu Asp Tyr Thr Lys  Cys Asp Leu 
    1295                 1300                 1305             


Thr Val  Tyr Ala Ile Asp Pro  Gln Thr Asn Arg Ala  Ile Asp Arg 
    1310                 1315                 1320             


Asn Glu  Leu Phe Lys Phe Leu  Asp Gly Lys Leu Leu  Asp Ile Asn 
    1325                 1330                 1335             


Lys Asp  Phe Gln Pro Tyr Tyr  Gly Glu Gly Gly Arg  Ile Leu Glu 
    1340                 1345                 1350             


Ile Arg  Thr Pro Glu Ala Val  Thr Ser Ile Lys Lys  Arg Gly Glu 
    1355                 1360                 1365             


Ser Leu  Gly Tyr Thr Glu Gly  Ala Leu Leu Ala Leu  Ala Phe Ile 
    1370                 1375                 1380             


Ile Ile  Leu Cys Cys Ile Pro  Ala Ile Leu Val Val  Leu Val Ser 
    1385                 1390                 1395             


Tyr Arg  Gln Phe Lys Val Arg  Gln Ala Glu Cys Thr  Lys Thr Ala 
    1400                 1405                 1410             


Arg Ile  Gln Ala Ala Leu Pro  Ala Ala Lys Pro Ala  Val Pro Ala 
    1415                 1420                 1425             


Pro Ala  Pro Val Ala Ala Pro  Pro Pro Pro Pro Pro  Pro Pro Pro 
    1430                 1435                 1440             


Gly Ala  His Leu Tyr Glu Glu  Leu Gly Asp Ser Ser  Ile Leu Phe 
    1445                 1450                 1455             


Leu Leu  Tyr His Phe Gln Gln  Ser Arg Gly Asn Asn  Ser Val Ser 
    1460                 1465                 1470             


Glu Asp  Arg Lys His Gln Gln  Val Val Met Pro Phe  Ser Ser Asn 
    1475                 1480                 1485             


Thr Ile  Glu Ala His Lys Ser  Ala His Val Asp Gly  Ser Leu Lys 
    1490                 1495                 1500             


Ser Asn  Lys Leu Lys Ser Ala  Arg Lys Phe Thr Phe  Leu Ser Asp 
    1505                 1510                 1515             


Glu Asp  Asp Leu Ser Ala His  Asn Pro Leu Tyr Lys  Glu Asn Ile 
    1520                 1525                 1530             


Ser Gln  Val Ser Thr Asn Ser  Asp Ile Ser Gln Arg  Thr Asp Phe 
    1535                 1540                 1545             


Val Asp  Pro Phe Ser Pro Lys  Ile Gln Ala Lys Ser  Lys Ser Leu 
    1550                 1555                 1560             


Arg Gly  Pro Arg Glu Lys Ile  Gln Arg Leu Trp Ser  Gln Ser Val 
    1565                 1570                 1575             


Ser Leu  Pro Arg Arg Leu Met  Arg Lys Val Pro Asn  Arg Pro Glu 
    1580                 1585                 1590             


Ile Ile  Asp Leu Gln Gln Trp  Gln Gly Thr Arg Gln  Lys Ala Glu 
    1595                 1600                 1605             


Asn Glu  Asn Thr Gly Ile Cys  Thr Asn Lys Arg Gly  Ser Ser Asn 
    1610                 1615                 1620             


Pro Leu  Leu Thr Thr Glu Glu  Ala Asn Leu Thr Glu  Lys Glu Glu 
    1625                 1630                 1635             


Ile Arg  Gln Gly Glu Thr Leu  Met Ile Glu Gly Thr  Glu Gln Leu 
    1640                 1645                 1650             


Lys Ser  Leu Ser Ser Asp Ser  Ser Phe Cys Phe Pro  Arg Pro His 
    1655                 1660                 1665             


Phe Ser  Phe Ser Thr Leu Pro  Thr Val Ser Arg Thr  Val Glu Leu 
    1670                 1675                 1680             


Lys Ser  Glu Pro Asn Val Ile  Ser Ser Pro Ala Glu  Cys Ser Leu 
    1685                 1690                 1695             


Glu Leu  Ser Pro Ser Arg Pro  Cys Val Leu His Ser  Ser Leu Ser 
    1700                 1705                 1710             


Arg Arg  Glu Thr Pro Ile Cys  Met Leu Pro Ile Glu  Thr Glu Arg 
    1715                 1720                 1725             


Asn Ile  Phe Glu Asn Phe Ala  His Pro Pro Asn Ile  Ser Pro Ser 
    1730                 1735                 1740             


Ala Cys  Pro Leu Pro Pro Pro  Pro Pro Ile Ser Pro  Pro Ser Pro 
    1745                 1750                 1755             


Pro Pro  Ala Pro Ala Pro Leu  Ala Pro Pro Pro Asp  Ile Ser Pro 
    1760                 1765                 1770             


Phe Ser  Leu Phe Cys Pro Pro  Pro Ser Pro Pro Ser  Ile Pro Leu 
    1775                 1780                 1785             


Pro Leu  Pro Pro Pro Thr Phe  Phe Pro Leu Ser Val  Ser Thr Ser 
    1790                 1795                 1800             


Gly Pro  Pro Thr Pro Pro Leu  Leu Pro Pro Phe Pro  Thr Pro Leu 
    1805                 1810                 1815             


Pro Pro  Pro Pro Pro Ser Ile  Pro Cys Pro Pro Pro  Pro Ser Ala 
    1820                 1825                 1830             


Ser Phe  Leu Ser Thr Glu Cys  Val Cys Ile Thr Gly  Val Lys Cys 
    1835                 1840                 1845             


Thr Thr  Asn Leu Met Pro Ala  Glu Lys Ile Lys Ser  Ser Met Thr 
    1850                 1855                 1860             


Gln Leu  Ser Thr Thr Thr Val  Cys Lys Thr Asp Pro  Gln Arg Glu 
    1865                 1870                 1875             


Pro Lys  Gly Ile Leu Arg His  Val Lys Asn Leu Ala  Glu Leu Glu 
    1880                 1885                 1890             


Lys Ser  Val Ala Asn Met Tyr  Ser Gln Ile Glu Lys  Asn Tyr Leu 
    1895                 1900                 1905             


Arg Thr  Asn Val Ser Glu Leu  Gln Thr Met Cys Pro  Ser Glu Val 
    1910                 1915                 1920             


Thr Asn  Met Glu Ile Thr Ser  Glu Gln Asn Lys Gly  Ser Leu Asn 
    1925                 1930                 1935             


Asn Ile  Val Glu Gly Thr Glu  Lys Gln Ser His Ser  Gln Ser Thr 
    1940                 1945                 1950             


Ser Leu  
    1955 


<210>  5446
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  5446

Met Asn Trp Val Asn Lys Ser Val Pro Gln Glu Phe Ile Leu Leu Val 
1               5                   10                  15      


Phe Ser Asp Gln Pro Trp Leu Glu Ile Pro Pro Phe Val Met Phe Leu 
            20                  25                  30          


Phe Ser Tyr Ile Leu Thr Ile Phe Gly Asn Leu Thr Ile Ile Leu Val 
        35                  40                  45              


Ser His Val Asp Phe Lys Leu His Thr Pro Met Tyr Phe Phe Leu Ser 
    50                  55                  60                  


Asn Leu Ser Leu Leu Asp Leu Cys Tyr Thr Thr Ser Thr Val Pro Gln 
65                  70                  75                  80  


Met Leu Val Asn Ile Cys Asn Thr Arg Lys Val Ile Ser Tyr Gly Gly 
                85                  90                  95      


Cys Val Ala Gln Leu Phe Ile Phe Leu Ala Leu Gly Ser Thr Glu Cys 
            100                 105                 110         


Leu Leu Leu Ala Val Met Cys Phe Asp Arg Phe Val Ala Ile Cys Arg 
        115                 120                 125             


Pro Leu His Tyr Ser Ile Ile Met His Gln Arg Leu Cys Phe Gln Leu 
    130                 135                 140                 


Ala Ala Ala Ser Trp Ile Ser Gly Phe Ser Asn Ser Val Leu Gln Ser 
145                 150                 155                 160 


Thr Trp Thr Leu Lys Met Pro Leu Cys Gly His Lys Glu Val Asp His 
                165                 170                 175     


Phe Phe Cys Glu Val Pro Ala Leu Leu Lys Leu Ser Cys Val Asp Thr 
            180                 185                 190         


Thr Ala Asn Glu Ala Glu Leu Phe Phe Ile Ser Val Leu Phe Leu Leu 
        195                 200                 205             


Ile Pro Val Thr Leu Ile Leu Ile Ser Tyr Ala Phe Ile Val Gln Ala 
    210                 215                 220                 


Val Leu Arg Ile Gln Ser Ala Glu Gly Gln Arg Lys Ala Phe Gly Thr 
225                 230                 235                 240 


Cys Gly Ser His Leu Ile Val Val Ser Leu Phe Tyr Gly Thr Ala Ile 
                245                 250                 255     


Ser Met Tyr Leu Gln Pro Pro Ser Pro Ser Ser Lys Asp Arg Gly Lys 
            260                 265                 270         


Met Val Ser Leu Phe Cys Gly Ile Ile Ala Pro Met Leu Asn Pro Leu 
        275                 280                 285             


Ile Tyr Thr Leu Arg Asn Lys Glu Val Lys Glu Ala Phe Lys Arg Leu 
    290                 295                 300                 


Val Ala Lys Ser Leu Leu Asn Gln Glu Ile Arg Asn Met Gln Met Ile 
305                 310                 315                 320 


Ser Phe Ala Lys Asp Thr Val Leu Thr Tyr Leu Thr Asn Phe Ser Ala 
                325                 330                 335     


Ser Cys Pro Ile Phe Val Ile Thr Ile Glu Asn Tyr Cys Asn Leu Pro 
            340                 345                 350         


Gln Arg Lys Phe Pro 
        355         


<210>  5447
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  5447

Met Gly Thr Thr Glu Ala Thr Leu Arg Met Glu Asn Val Asp Val Lys 
1               5                   10                  15      


Glu Glu Trp Gln Asp Glu Asp Leu Pro Arg Pro Leu Pro Glu Glu Thr 
            20                  25                  30          


Gly Val Glu Leu Leu Gly Ser Pro Val Glu Asp Thr Ser Ser Pro Pro 
        35                  40                  45              


Asn Thr Leu Asn Phe Asn Gly Ala His Arg Lys Arg Lys Thr Leu Val 
    50                  55                  60                  


Ala Pro Glu Ile Asn Ile Ser Leu Asp Gln Ser Glu Gly Ser Leu Leu 
65                  70                  75                  80  


Ser Asp Asp Phe Leu Asp Thr Pro Asp Asp Leu Asp Ile Asn Val Asp 
                85                  90                  95      


Asp Ile Glu Thr Pro Asp Glu Thr Asp Ser Leu Glu Phe Leu Gly Asn 
            100                 105                 110         


Gly Asn Glu Leu Glu Trp Glu Asp Asp Thr Pro Val Ala Thr Ala Lys 
        115                 120                 125             


Asn Met Pro Gly Asp Ser Ala Asp Leu Phe Gly Asp Gly Thr Thr Glu 
    130                 135                 140                 


Asp Gly Ser Ala Ala Asn Gly Arg Leu Trp Arg Thr Val Ile Ile Gly 
145                 150                 155                 160 


Glu Gln Glu His Arg Ile Asp Leu His Met Ile Arg Pro Tyr Met Lys 
                165                 170                 175     


Val Val Thr His Gly Gly Tyr Tyr Gly Glu Gly Leu Asn Ala Ile Ile 
            180                 185                 190         


Val Phe Ala Ala Cys Phe Leu Pro Asp Ser Ser Leu Pro Asp Tyr His 
        195                 200                 205             


Tyr Ile Met Glu Asn Leu Phe Leu Tyr Val Ile Ser Ser Leu Glu Leu 
    210                 215                 220                 


Leu Val Ala Glu Asp Tyr Met Ile Val Tyr Leu Asn Gly Ala Thr Pro 
225                 230                 235                 240 


Arg Arg Arg Met Pro Gly Ile Gly Trp Leu Lys Lys Cys Tyr Gln Met 
                245                 250                 255     


Ile Asp Arg Arg Leu Arg Lys Asn Leu Lys Ser Leu Ile Ile Val His 
            260                 265                 270         


Pro Ser Trp Phe Ile Arg Thr Val Leu Ala Ile Ser Arg Pro Phe Ile 
        275                 280                 285             


Ser Val Lys Phe Ile Asn Lys Ile Gln Tyr Val His Ser Leu Glu Asp 
    290                 295                 300                 


Leu Glu Gln Leu Ile Pro Met Glu His Val Gln Ile Pro Asp Cys Val 
305                 310                 315                 320 


Leu Gln Tyr Glu Glu Glu Arg Leu Lys Ala Arg Arg Glu Ser Ala Arg 
                325                 330                 335     


Pro Gln Pro Glu Phe Val Leu Pro Arg Ser Glu Glu Lys Pro Glu Val 
            340                 345                 350         


Ala Pro Val Glu Asn Arg Ser Ala Leu Val Ser Glu Asp Gln Glu Thr 
        355                 360                 365             


Ser Met Ser 
    370     


<210>  5448
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  5448

Met Ala Gly Leu Gly Phe Trp Gly His Pro Ala Gly Pro Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Leu Pro Pro Arg Ala Leu Pro Glu Gly Pro Leu 
            20                  25                  30          


Val Phe Val Ala Leu Val Phe Arg His Gly Asp Arg Ala Pro Leu Ala 
        35                  40                  45              


Ser Tyr Pro Met Asp Pro His Lys Glu Val Ala Ser Thr Leu Trp Pro 
    50                  55                  60                  


Arg Gly Leu Gly Gln Leu Thr Thr Glu Gly Val Arg Gln Gln Leu Glu 
65                  70                  75                  80  


Leu Gly Arg Phe Leu Arg Ser Arg Tyr Glu Ala Phe Leu Ser Pro Glu 
                85                  90                  95      


Tyr Arg Arg Glu Glu Val Tyr Ile Arg Ser Thr Asp Phe Asp Arg Thr 
            100                 105                 110         


Leu Glu Ser Ala Gln Ala Asn Leu Ala Gly Leu Phe Pro Glu Ala Ala 
        115                 120                 125             


Pro Gly Ser Pro Glu Ala Arg Trp Arg Pro Ile Pro Val His Thr Val 
    130                 135                 140                 


Pro Val Ala Glu Asp Lys Leu Leu Arg Phe Pro Met Arg Ser Cys Pro 
145                 150                 155                 160 


Arg Tyr His Glu Leu Leu Arg Glu Ala Thr Glu Ala Ala Glu Tyr Gln 
                165                 170                 175     


Glu Ala Leu Glu Gly Trp Thr Gly Phe Leu Ser Arg Leu Glu Asn Phe 
            180                 185                 190         


Thr Gly Leu Ser Leu Val Gly Glu Pro Leu Arg Arg Ala Trp Lys Val 
        195                 200                 205             


Leu Asp Thr Leu Met Cys Gln Gln Ala His Gly Leu Pro Leu Pro Ala 
    210                 215                 220                 


Trp Ala Ser Pro Asp Val Leu Arg Thr Leu Ala Gln Ile Ser Ala Leu 
225                 230                 235                 240 


Asp Ile Gly Ala His Val Gly Pro Pro Arg Ala Ala Glu Lys Ala Gln 
                245                 250                 255     


Leu Thr Gly Gly Ile Leu Leu Asn Ala Ile Leu Ala Asn Phe Ser Arg 
            260                 265                 270         


Val Gln Arg Leu Gly Leu Pro Leu Lys Met Val Met Tyr Ser Ala His 
        275                 280                 285             


Asp Ser Thr Leu Leu Ala Leu Gln Gly Ala Leu Gly Leu Tyr Asp Gly 
    290                 295                 300                 


His Thr Pro Pro Tyr Ala Ala Cys Leu Gly Phe Glu Phe Arg Lys His 
305                 310                 315                 320 


Leu Gly Asn Pro Ala Lys Asp Gly Gly Asn Val Thr Val Ser Leu Phe 
                325                 330                 335     


Tyr Arg Asn Asp Ser Ala His Leu Pro Leu Pro Leu Ser Leu Pro Gly 
            340                 345                 350         


Cys Pro Ala Pro Cys Pro Leu Gly Arg Phe Tyr Gln Leu Thr Ala Pro 
        355                 360                 365             


Ala Arg Pro Pro Ala His Gly Val Ser Cys His Gly Pro Tyr Glu Ala 
    370                 375                 380                 


Ala Ile Pro Pro Ala Pro Val Val Pro Leu Leu Ala Gly Ala Val Ala 
385                 390                 395                 400 


Val Leu Val Ala Leu Ser Leu Gly Leu Gly Leu Leu Ala Trp Arg Pro 
                405                 410                 415     


Gly Cys Leu Arg Ala Leu Gly Gly Pro Val 
            420                 425     


<210>  5449
<211>  859
<212>  PRT
<213>  Homo sapiens

<400>  5449

Met Arg Arg Cys Arg Trp Ala Ala Leu Ala Leu Gly Leu Leu Arg Leu 
1               5                   10                  15      


Cys Leu Ala Gln Ala Asn Phe Ala Pro His Phe Phe Asp Asn Gly Val 
            20                  25                  30          


Gly Ser Thr Asn Gly Asn Met Ala Leu Phe Ser Leu Pro Glu Asp Thr 
        35                  40                  45              


Pro Val Gly Ser His Val Tyr Thr Leu Asn Gly Thr Asp Pro Glu Gly 
    50                  55                  60                  


Asp Pro Ile Ser Tyr His Ile Ser Phe Asp Pro Ser Thr Arg Ser Val 
65                  70                  75                  80  


Phe Ser Val Asp Pro Thr Phe Gly Asn Ile Thr Leu Val Glu Glu Leu 
                85                  90                  95      


Asp Arg Glu Arg Glu Asp Glu Ile Glu Ala Ile Ile Ser Ile Ser Asp 
            100                 105                 110         


Gly Leu Asn Leu Val Ala Glu Lys Val Val Ile Leu Val Thr Asp Ala 
        115                 120                 125             


Asn Asp Glu Ala Pro Arg Phe Ile Gln Glu Pro Tyr Val Ala Leu Val 
    130                 135                 140                 


Pro Glu Asp Ile Pro Ala Gly Ser Ile Ile Phe Lys Val His Ala Val 
145                 150                 155                 160 


Asp Arg Asp Thr Gly Ser Gly Gly Ser Val Thr Tyr Phe Leu Gln Asn 
                165                 170                 175     


Leu His Ser Pro Phe Ala Val Asp Arg His Ser Gly Val Leu Arg Leu 
            180                 185                 190         


Gln Ala Gly Ala Thr Leu Asp Tyr Glu Arg Ser Arg Thr His Tyr Ile 
        195                 200                 205             


Thr Val Val Ala Lys Asp Gly Gly Gly Arg Leu His Gly Ala Asp Val 
    210                 215                 220                 


Val Phe Ser Ala Thr Thr Thr Val Thr Val Asn Val Glu Asp Val Gln 
225                 230                 235                 240 


Asp Met Ala Pro Val Phe Val Gly Thr Pro Tyr Tyr Gly Tyr Val Tyr 
                245                 250                 255     


Glu Asp Thr Leu Pro Gly Ser Glu Val Leu Lys Val Val Ala Met Asp 
            260                 265                 270         


Gly Asp Arg Gly Lys Pro Asn Arg Ile Leu Tyr Ser Leu Val Asn Gly 
        275                 280                 285             


Asn Asp Gly Ala Phe Glu Ile Asn Glu Thr Ser Gly Ala Ile Ser Ile 
    290                 295                 300                 


Thr Gln Ser Pro Ala Gln Leu Gln Arg Glu Val Tyr Glu Leu His Val 
305                 310                 315                 320 


Gln Val Thr Glu Met Ser Pro Ala Gly Ser Pro Ala Ala Gln Ala Thr 
                325                 330                 335     


Val Pro Val Thr Ile Arg Ile Val Asp Leu Asn Asn His Pro Pro Thr 
            340                 345                 350         


Phe Tyr Gly Glu Ser Gly Pro Gln Asn Arg Phe Glu Leu Ser Met Asn 
        355                 360                 365             


Glu His Pro Pro Gln Gly Glu Ile Leu Arg Gly Leu Lys Ile Thr Val 
    370                 375                 380                 


Asn Asp Ser Asp Gln Gly Ala Asn Ala Lys Phe Asn Leu Gln Leu Val 
385                 390                 395                 400 


Gly Pro Arg Gly Ile Phe Arg Val Val Pro Gln Thr Val Leu Asn Glu 
                405                 410                 415     


Ala Gln Val Thr Ile Ile Val Glu Asn Ser Ala Ala Ile Asp Phe Glu 
            420                 425                 430         


Lys Ser Lys Val Leu Thr Phe Lys Leu Leu Ala Val Glu Val Asn Thr 
        435                 440                 445             


Pro Glu Lys Phe Ser Ser Thr Ala Asp Val Val Ile Gln Leu Leu Asp 
    450                 455                 460                 


Thr Asn Asp Asn Val Pro Lys Phe Asp Ser Leu Tyr Tyr Val Ala Arg 
465                 470                 475                 480 


Ile Pro Glu Asn Ala Pro Gly Gly Ser Ser Val Val Ala Val Thr Ala 
                485                 490                 495     


Val Asp Pro Asp Thr Gly Pro Trp Gly Glu Val Lys Tyr Ser Thr Tyr 
            500                 505                 510         


Gly Thr Gly Ala Asp Leu Phe Leu Ile His Pro Ser Thr Gly Leu Ile 
        515                 520                 525             


Tyr Thr Gln Pro Trp Ala Ser Leu Asp Ala Glu Ala Thr Ala Arg Tyr 
    530                 535                 540                 


Asn Phe Tyr Val Lys Ala Glu Asp Met Glu Gly Lys Tyr Ser Val Ala 
545                 550                 555                 560 


Glu Val Phe Ile Thr Leu Leu Asp Val Asn Asp His Pro Pro Gln Phe 
                565                 570                 575     


Gly Lys Ser Val Gln Lys Lys Thr Met Val Leu Gly Thr Pro Val Lys 
            580                 585                 590         


Ile Glu Ala Ile Asp Glu Asp Ala Glu Glu Pro Asn Asn Leu Val Asp 
        595                 600                 605             


Tyr Ser Ile Thr His Ala Glu Pro Ala Asn Val Phe Asp Ile Asn Ser 
    610                 615                 620                 


His Thr Gly Glu Ile Trp Leu Lys Asn Ser Ile Arg Ser Leu Asp Ala 
625                 630                 635                 640 


Leu His Asn Ile Thr Pro Gly Arg Asp Cys Leu Trp Ser Leu Glu Val 
                645                 650                 655     


Gln Ala Lys Asp Arg Gly Ser Pro Ser Phe Ser Thr Thr Ala Leu Leu 
            660                 665                 670         


Lys Ile Asp Ile Thr Asp Ala Glu Thr Leu Ser Arg Ser Pro Met Ala 
        675                 680                 685             


Ala Phe Leu Ile Gln Thr Lys Asp Asn Pro Met Lys Ala Val Gly Val 
    690                 695                 700                 


Leu Ala Gly Thr Met Ala Thr Val Val Ala Ile Thr Val Leu Ile Ser 
705                 710                 715                 720 


Thr Ala Thr Phe Trp Arg Asn Lys Lys Ser Asn Lys Val Leu Pro Met 
                725                 730                 735     


Arg Arg Val Leu Arg Lys Arg Pro Ser Pro Ala Pro Arg Thr Ile Arg 
            740                 745                 750         


Ile Glu Trp Leu Lys Ser Lys Ser Thr Lys Ala Ala Thr Lys Phe Met 
        755                 760                 765             


Leu Lys Glu Lys Pro Pro Asn Glu Asn Cys Asn Asn Asn Ser Pro Glu 
    770                 775                 780                 


Ser Ser Leu Leu Pro Arg Ala Pro Ala Leu Pro Pro Pro Pro Ser Val 
785                 790                 795                 800 


Ala Pro Ser Thr Gly Ala Ala Gln Trp Thr Val Pro Thr Val Ser Gly 
                805                 810                 815     


Ser Leu Thr Pro Gln Pro Thr Gln Pro Pro Pro Lys Pro Lys Thr Met 
            820                 825                 830         


Gly Ser Pro Val Gln Ser Thr Leu Ile Ser Glu Leu Lys Gln Lys Phe 
        835                 840                 845             


Glu Lys Lys Ser Val His Asn Lys Ala Tyr Phe 
    850                 855                 


<210>  5450
<211>  553
<212>  PRT
<213>  Homo sapiens

<400>  5450

Met Val Gln Arg Leu Trp Val Ser Arg Leu Leu Arg His Arg Lys Ala 
1               5                   10                  15      


Gln Leu Leu Leu Val Asn Leu Leu Thr Phe Gly Leu Glu Val Cys Leu 
            20                  25                  30          


Ala Ala Gly Ile Thr Tyr Val Pro Pro Leu Leu Leu Glu Val Gly Val 
        35                  40                  45              


Glu Glu Lys Phe Met Thr Met Val Leu Gly Ile Gly Pro Val Leu Gly 
    50                  55                  60                  


Leu Val Cys Val Pro Leu Leu Gly Ser Ala Ser Asp His Trp Arg Gly 
65                  70                  75                  80  


Arg Tyr Gly Arg Arg Arg Pro Phe Ile Trp Ala Leu Ser Leu Gly Ile 
                85                  90                  95      


Leu Leu Ser Leu Phe Leu Ile Pro Arg Ala Gly Trp Leu Ala Gly Leu 
            100                 105                 110         


Leu Cys Pro Asp Pro Arg Pro Leu Glu Leu Ala Leu Leu Ile Leu Gly 
        115                 120                 125             


Val Gly Leu Leu Asp Phe Cys Gly Gln Val Cys Phe Thr Pro Leu Glu 
    130                 135                 140                 


Ala Leu Leu Ser Asp Leu Phe Arg Asp Pro Asp His Cys Arg Gln Ala 
145                 150                 155                 160 


Tyr Ser Val Tyr Ala Phe Met Ile Ser Leu Gly Gly Cys Leu Gly Tyr 
                165                 170                 175     


Leu Leu Pro Ala Ile Asp Trp Asp Thr Ser Ala Leu Ala Pro Tyr Leu 
            180                 185                 190         


Gly Thr Gln Glu Glu Cys Leu Phe Gly Leu Leu Thr Leu Ile Phe Leu 
        195                 200                 205             


Thr Cys Val Ala Ala Thr Leu Leu Val Ala Glu Glu Ala Ala Leu Gly 
    210                 215                 220                 


Pro Thr Glu Pro Ala Glu Gly Leu Ser Ala Pro Ser Leu Ser Pro His 
225                 230                 235                 240 


Cys Cys Pro Cys Arg Ala Arg Leu Ala Phe Arg Asn Leu Gly Ala Leu 
                245                 250                 255     


Leu Pro Arg Leu His Gln Leu Cys Cys Arg Met Pro Arg Thr Leu Arg 
            260                 265                 270         


Arg Leu Phe Val Ala Glu Leu Cys Ser Trp Met Ala Leu Met Thr Phe 
        275                 280                 285             


Thr Leu Phe Tyr Thr Asp Phe Val Gly Glu Gly Leu Tyr Gln Gly Val 
    290                 295                 300                 


Pro Arg Ala Glu Pro Gly Thr Glu Ala Arg Arg His Tyr Asp Glu Gly 
305                 310                 315                 320 


Val Arg Met Gly Ser Leu Gly Leu Phe Leu Gln Cys Ala Ile Ser Leu 
                325                 330                 335     


Val Phe Ser Leu Val Met Asp Arg Leu Val Gln Arg Phe Gly Thr Arg 
            340                 345                 350         


Ala Val Tyr Leu Ala Ser Val Ala Ala Phe Pro Val Ala Ala Gly Ala 
        355                 360                 365             


Thr Cys Leu Ser His Ser Val Ala Val Val Thr Ala Ser Ala Ala Leu 
    370                 375                 380                 


Thr Gly Phe Thr Phe Ser Ala Leu Gln Ile Leu Pro Tyr Thr Leu Ala 
385                 390                 395                 400 


Ser Leu Tyr His Arg Glu Lys Gln Val Phe Leu Pro Lys Tyr Arg Gly 
                405                 410                 415     


Asp Thr Gly Gly Ala Ser Ser Glu Asp Ser Leu Met Thr Ser Phe Leu 
            420                 425                 430         


Pro Gly Pro Lys Pro Gly Ala Pro Phe Pro Asn Gly His Val Gly Ala 
        435                 440                 445             


Gly Gly Ser Gly Leu Leu Pro Pro Pro Pro Ala Leu Cys Gly Ala Ser 
    450                 455                 460                 


Ala Cys Asp Val Ser Val Arg Val Val Val Gly Glu Pro Thr Glu Ala 
465                 470                 475                 480 


Arg Val Val Pro Gly Arg Gly Ile Cys Leu Asp Leu Ala Ile Leu Asp 
                485                 490                 495     


Ser Ala Phe Leu Leu Ser Gln Val Ala Pro Ser Leu Phe Met Gly Ser 
            500                 505                 510         


Ile Val Gln Leu Ser Gln Ser Val Thr Ala Tyr Met Val Ser Ala Ala 
        515                 520                 525             


Gly Leu Gly Leu Val Ala Ile Tyr Phe Ala Thr Gln Val Val Phe Asp 
    530                 535                 540                 


Lys Ser Asp Leu Ala Lys Tyr Ser Ala 
545                 550             


<210>  5451
<211>  752
<212>  PRT
<213>  Homo sapiens

<400>  5451

Met Ser Tyr Gly Glu Ile Glu Glu Phe Cys Leu Val Arg Ile Val Met 
1               5                   10                  15      


Ala Leu Cys Ser Ala Leu Met Thr Ile Phe Thr Ile Lys Met Gly Thr 
            20                  25                  30          


Ala Lys Gln Ala Ile Asp Gln Gly Arg Ser Pro Val Ile Ile Asp Asn 
        35                  40                  45              


Thr Asn Ile Gln Ala Trp Glu Met Lys Pro Tyr Val Glu Val Ala Ile 
    50                  55                  60                  


Gly Lys Gly Tyr Arg Val Glu Phe His Glu Pro Glu Thr Trp Trp Lys 
65                  70                  75                  80  


Phe Asp Pro Glu Glu Leu Glu Lys Arg Asn Lys His Gly Val Ser Arg 
                85                  90                  95      


Lys Lys Ile Ala Gln Met Leu Asp Arg Tyr Glu Tyr Gln Met Ser Ile 
            100                 105                 110         


Ser Ile Val Met Asn Ser Val Glu Pro Ser His Lys Ser Thr Gln Arg 
        115                 120                 125             


Pro Pro Pro Pro Gln Gly Arg Gln Arg Glu Arg Val Leu Lys Lys Thr 
    130                 135                 140                 


Gly His Arg Leu Ser Lys Thr Lys Gln Lys Arg Asn Arg Lys Arg Asn 
145                 150                 155                 160 


Lys Lys Gln Asn Ser Gln Asn Arg Ile Met Glu Glu Asn Ser Leu Glu 
                165                 170                 175     


Phe Leu Ser Asp Leu Thr Pro Gly Asp Gln Asp Pro Ser Gln Ser Glu 
            180                 185                 190         


Glu Glu Asp Ile Glu Lys Thr Arg Arg Glu Ser Glu Tyr Pro Phe Ile 
        195                 200                 205             


Asp Gly Leu Gln Asn Glu Val Gly Asp Phe Val Thr Gly Tyr Lys Glu 
    210                 215                 220                 


Lys Arg Trp Lys Asn Lys Asp Pro Lys Asp Ser Phe Gln Asn Val Met 
225                 230                 235                 240 


Ser Ile Val Glu Leu Asp Asn Thr Pro Lys Asn Tyr Leu Ser Lys Glu 
                245                 250                 255     


Gly Asp Asn Leu Phe Val Ser Leu Leu Leu Arg Pro Asn Glu Ile Ser 
            260                 265                 270         


Val Thr Cys Pro Ile Leu Thr Gln Asn Leu Ser Cys Val Thr Thr Asp 
        275                 280                 285             


Asp Cys Ser Gly Met Lys Val Glu Lys His Ile Arg Asn Arg His Thr 
    290                 295                 300                 


Ile Ala Leu Asp Thr Gln Asp Leu Ser Ala Glu Thr Ser Cys Leu Phe 
305                 310                 315                 320 


Met Lys Lys Arg Glu Ile Val Asp Lys Asn Leu Ser His Glu Pro Ile 
                325                 330                 335     


Leu Cys His Gln His Gly Ile Arg Met Ser Asp Lys Val Leu Arg Glu 
            340                 345                 350         


Glu Gln Val Tyr Thr Thr Lys Ile Asn His Trp Ala Phe Phe Thr Thr 
        355                 360                 365             


Asn Leu Ser Asp Glu Asp Leu Gln Leu Gly Ser Asp Arg Gln Pro Tyr 
    370                 375                 380                 


Phe Gly Ser Trp Pro Ala Gly Pro His Lys Phe Ile Cys Glu Gln Arg 
385                 390                 395                 400 


Pro Lys Lys Asp Arg Ala Cys Lys Leu Ala Gly Pro Asp Ser Arg Gly 
                405                 410                 415     


Gln Trp Ile Gln Met Ile Phe Thr Ser Val Ala Ala Ser Glu Pro Gly 
            420                 425                 430         


Asn Asn Pro Glu Ile Leu Thr Asp Lys Leu Leu Ile Gly Asn Glu Asp 
        435                 440                 445             


Phe Ser Pro Pro Pro Glu Thr Met Asp Ser Phe Ile Glu Thr Asn Leu 
    450                 455                 460                 


Phe Arg Ser Cys Leu Pro Gln Pro Asp Ile Pro Lys Asn Ala Leu Glu 
465                 470                 475                 480 


Ser Thr Lys Asn Lys Lys Arg Arg Lys Lys Arg Ile Phe Asn Leu Val 
                485                 490                 495     


Pro Asn Phe Asp Leu Leu Gly Gln Ser Arg Ile Gly Val Lys Glu Arg 
            500                 505                 510         


Glu Lys Cys Asp Leu Leu Thr Lys Asn His Gly Leu Lys Ile Thr Leu 
        515                 520                 525             


Gly Glu Glu Lys Asp Arg Ile Ser Glu Arg Asn Ser Glu Glu Glu Asn 
    530                 535                 540                 


Lys Gln Lys Leu Met Thr Phe Asp His His Pro Leu Trp Phe Tyr Leu 
545                 550                 555                 560 


Asp Ile Ile Lys Ala Thr Pro Leu Asn Ile Asp Gly Gln Arg Tyr Ser 
                565                 570                 575     


His Cys Leu Ser Phe Asn Arg Leu Arg Cys Ser Ala Ser Leu Tyr Lys 
            580                 585                 590         


Asn Tyr Ile Pro Ser Phe Val Leu His Asn Leu Ser Ser Ile Trp Lys 
        595                 600                 605             


Pro Ser Phe Thr Asn Lys Lys Leu Phe Leu Thr Phe Glu Ser Gln Thr 
    610                 615                 620                 


Arg Val Gly Asn Lys Leu Asn Asp Ala Gly Phe Ile Ser Pro Glu Ile 
625                 630                 635                 640 


Leu His Ser His Pro Asp Thr Ser Cys Ser Leu Gly Val Thr Ser Asp 
                645                 650                 655     


Phe His Phe Leu Asn Glu Arg Phe Asp Arg Lys Leu Lys Arg Trp Glu 
            660                 665                 670         


Glu Pro Lys Glu Leu Pro Ala Glu Asp Ser Gln Asp Leu Thr Ser Thr 
        675                 680                 685             


Asp Tyr Arg Ser Leu Glu Leu Pro Leu Ser Gln Gly Phe Ala Phe Gln 
    690                 695                 700                 


Leu Val Lys Leu Phe Gly Ser Pro Gly Val Pro Met Glu Ser Leu Leu 
705                 710                 715                 720 


Pro Asp Asp Tyr Val Val Pro Leu Asp Trp Lys Thr Leu Lys Met Ile 
                725                 730                 735     


Tyr Leu Gln Trp Lys Met Ser Val Glu Lys Arg Gln Lys Lys Ile Gly 
            740                 745                 750         


<210>  5452
<211>  577
<212>  PRT
<213>  Homo sapiens

<400>  5452

Met Gly Ser Arg His Phe Glu Gly Ile Tyr Asp His Val Gly His Phe 
1               5                   10                  15      


Gly Arg Phe Gln Arg Val Leu Tyr Phe Ile Cys Ala Phe Gln Asn Ile 
            20                  25                  30          


Ser Cys Gly Ile His Tyr Leu Ala Ser Val Phe Met Gly Val Thr Pro 
        35                  40                  45              


His His Val Cys Arg Pro Pro Gly Asn Val Ser Gln Val Val Phe His 
    50                  55                  60                  


Asn His Ser Asn Trp Ser Leu Glu Asp Thr Gly Ala Leu Leu Ser Ser 
65                  70                  75                  80  


Gly Gln Lys Asp Tyr Val Thr Val Gln Leu Gln Asn Gly Glu Ile Trp 
                85                  90                  95      


Glu Leu Ser Arg Cys Ser Arg Asn Lys Arg Glu Asn Thr Ser Ser Leu 
            100                 105                 110         


Gly Tyr Glu Tyr Thr Gly Ser Lys Lys Glu Phe Pro Cys Val Asp Gly 
        115                 120                 125             


Tyr Ile Tyr Asp Gln Asn Thr Trp Lys Ser Thr Ala Val Thr Gln Trp 
    130                 135                 140                 


Asn Leu Val Cys Asp Arg Lys Trp Leu Ala Met Leu Ile Gln Pro Leu 
145                 150                 155                 160 


Phe Met Phe Gly Val Leu Leu Gly Ser Val Thr Phe Gly Tyr Phe Ser 
                165                 170                 175     


Asp Arg Leu Gly Arg Arg Val Val Leu Trp Ala Thr Ser Ser Ser Met 
            180                 185                 190         


Phe Leu Phe Gly Ile Ala Ala Ala Phe Ala Val Asp Tyr Tyr Thr Phe 
        195                 200                 205             


Met Ala Ala Arg Phe Phe Leu Ala Met Val Ala Ser Gly Tyr Leu Val 
    210                 215                 220                 


Val Gly Phe Val Tyr Val Met Glu Phe Ile Gly Met Lys Ser Arg Thr 
225                 230                 235                 240 


Trp Ala Ser Val His Leu His Ser Phe Phe Ala Val Gly Thr Leu Leu 
                245                 250                 255     


Val Ala Leu Thr Gly Tyr Leu Val Arg Thr Trp Trp Leu Tyr Gln Met 
            260                 265                 270         


Ile Leu Ser Thr Val Thr Val Pro Phe Ile Leu Cys Cys Trp Val Leu 
        275                 280                 285             


Pro Glu Thr Pro Phe Trp Leu Leu Ser Glu Gly Arg Tyr Glu Glu Ala 
    290                 295                 300                 


Gln Lys Ile Val Asp Ile Met Ala Lys Trp Asn Arg Ala Ser Ser Cys 
305                 310                 315                 320 


Lys Leu Ser Glu Leu Leu Ser Leu Asp Leu Gln Gly Pro Val Ser Asn 
                325                 330                 335     


Ser Pro Thr Glu Val Gln Lys His Asn Leu Ser Tyr Leu Phe Tyr Asn 
            340                 345                 350         


Trp Ser Ile Thr Lys Arg Thr Leu Thr Val Trp Leu Ile Trp Phe Thr 
        355                 360                 365             


Gly Ser Leu Gly Phe Tyr Ser Phe Ser Leu Asn Ser Val Asn Leu Gly 
    370                 375                 380                 


Gly Asn Glu Tyr Leu Asn Leu Phe Leu Leu Gly Val Val Glu Ile Pro 
385                 390                 395                 400 


Ala Tyr Thr Phe Val Cys Ile Ala Met Asp Lys Val Gly Arg Arg Thr 
                405                 410                 415     


Val Leu Ala Tyr Ser Leu Phe Cys Ser Ala Leu Ala Cys Gly Val Val 
            420                 425                 430         


Met Val Ile Pro Gln Lys His Tyr Ile Leu Gly Val Val Thr Ala Met 
        435                 440                 445             


Val Gly Lys Phe Ala Ile Gly Ala Ala Phe Gly Leu Ile Tyr Leu Tyr 
    450                 455                 460                 


Thr Ala Glu Leu Tyr Pro Thr Ile Val Arg Ser Leu Ala Val Gly Ser 
465                 470                 475                 480 


Gly Ser Met Val Cys Arg Leu Ala Ser Ile Leu Ala Pro Phe Ser Val 
                485                 490                 495     


Asp Leu Ser Ser Ile Trp Ile Phe Ile Pro Gln Leu Phe Val Gly Thr 
            500                 505                 510         


Met Ala Leu Leu Ser Gly Val Leu Thr Leu Lys Leu Pro Glu Thr Leu 
        515                 520                 525             


Gly Lys Arg Leu Ala Thr Thr Trp Glu Glu Ala Ala Lys Leu Glu Ser 
    530                 535                 540                 


Glu Asn Glu Ser Lys Ser Ser Lys Leu Leu Leu Thr Thr Asn Asn Ser 
545                 550                 555                 560 


Gly Leu Glu Lys Thr Glu Ala Ile Thr Pro Arg Asp Ser Gly Leu Gly 
                565                 570                 575     


Glu 
    


<210>  5453
<211>  1382
<212>  PRT
<213>  Homo sapiens

<400>  5453

Met Thr Arg Lys Arg Thr Tyr Trp Val Pro Asn Ser Ser Gly Gly Leu 
1               5                   10                  15      


Val Asn Arg Gly Ile Asp Ile Gly Asp Asp Met Val Ser Gly Leu Ile 
            20                  25                  30          


Tyr Lys Thr Tyr Thr Leu Gln Asp Gly Pro Trp Ser Gln Gln Glu Arg 
        35                  40                  45              


Asn Pro Glu Ala Pro Gly Arg Ala Ala Val Pro Pro Trp Gly Lys Tyr 
    50                  55                  60                  


Asp Ala Ala Leu Arg Thr Met Ile Pro Phe Arg Pro Lys Pro Arg Phe 
65                  70                  75                  80  


Pro Ala Pro Gln Pro Leu Asp Asn Ala Gly Leu Phe Ser Tyr Leu Thr 
                85                  90                  95      


Val Ser Trp Leu Thr Pro Leu Met Ile Gln Ser Leu Arg Ser Arg Leu 
            100                 105                 110         


Asp Glu Asn Thr Ile Pro Pro Leu Ser Val His Asp Ala Ser Asp Lys 
        115                 120                 125             


Asn Val Gln Arg Leu His Arg Leu Trp Glu Glu Glu Val Ser Arg Arg 
    130                 135                 140                 


Gly Ile Glu Lys Ala Ser Val Leu Leu Val Met Leu Arg Phe Gln Arg 
145                 150                 155                 160 


Thr Arg Leu Ile Phe Asp Ala Leu Leu Gly Ile Cys Phe Cys Ile Ala 
                165                 170                 175     


Ser Val Leu Gly Pro Ile Leu Ile Ile Pro Lys Ile Leu Glu Tyr Ser 
            180                 185                 190         


Glu Glu Gln Leu Gly Asn Val Val His Gly Val Gly Leu Cys Phe Ala 
        195                 200                 205             


Leu Phe Leu Ser Glu Cys Val Lys Ser Leu Ser Phe Ser Ser Ser Trp 
    210                 215                 220                 


Ile Ile Asn Gln Arg Thr Ala Ile Arg Phe Arg Ala Ala Val Ser Ser 
225                 230                 235                 240 


Phe Ala Phe Glu Lys Leu Ile Gln Phe Lys Ser Val Ile His Ile Thr 
                245                 250                 255     


Ser Gly Glu Ala Ile Ser Phe Phe Thr Gly Asp Val Asn Tyr Leu Phe 
            260                 265                 270         


Glu Gly Val Cys Tyr Gly Pro Leu Val Leu Ile Thr Cys Ala Ser Leu 
        275                 280                 285             


Val Ile Cys Ser Ile Ser Ser Tyr Phe Ile Ile Gly Tyr Thr Ala Phe 
    290                 295                 300                 


Ile Ala Ile Leu Cys Tyr Leu Leu Val Phe Pro Leu Ala Val Phe Met 
305                 310                 315                 320 


Thr Arg Met Ala Val Lys Ala Gln His His Thr Ser Glu Val Ser Asp 
                325                 330                 335     


Gln Arg Ile Arg Val Thr Ser Glu Val Leu Thr Cys Ile Lys Leu Ile 
            340                 345                 350         


Lys Met Tyr Thr Trp Glu Lys Pro Phe Ala Lys Ile Ile Glu Asp Leu 
        355                 360                 365             


Arg Arg Lys Glu Arg Lys Leu Leu Glu Lys Cys Gly Leu Val Gln Ser 
    370                 375                 380                 


Leu Thr Ser Ile Thr Leu Phe Ile Ile Pro Thr Val Ala Thr Ala Val 
385                 390                 395                 400 


Trp Val Leu Ile His Thr Ser Leu Lys Leu Lys Leu Thr Ala Ser Met 
                405                 410                 415     


Ala Phe Ser Met Leu Ala Ser Leu Asn Leu Leu Arg Leu Ser Val Phe 
            420                 425                 430         


Phe Val Pro Ile Ala Val Lys Gly Leu Thr Asn Ser Lys Ser Ala Val 
        435                 440                 445             


Met Arg Phe Lys Lys Phe Phe Leu Gln Glu Ser Pro Val Phe Tyr Val 
    450                 455                 460                 


Gln Thr Leu Gln Asp Pro Ser Lys Ala Leu Val Phe Glu Glu Ala Thr 
465                 470                 475                 480 


Leu Ser Trp Gln Gln Thr Cys Pro Gly Ile Val Asn Gly Ala Leu Glu 
                485                 490                 495     


Leu Glu Arg Asn Gly His Ala Ser Glu Gly Met Thr Arg Pro Arg Asp 
            500                 505                 510         


Ala Leu Gly Pro Glu Glu Glu Gly Asn Ser Leu Gly Pro Glu Leu His 
        515                 520                 525             


Lys Ile Asn Leu Val Val Ser Lys Gly Met Met Leu Gly Val Cys Gly 
    530                 535                 540                 


Asn Thr Gly Ser Gly Lys Ser Ser Leu Leu Ser Ala Ile Leu Glu Glu 
545                 550                 555                 560 


Met His Leu Leu Glu Gly Ser Val Gly Val Gln Gly Ser Leu Ala Tyr 
                565                 570                 575     


Val Pro Gln Gln Ala Trp Ile Val Ser Gly Asn Ile Arg Glu Asn Ile 
            580                 585                 590         


Leu Met Gly Gly Ala Tyr Asp Lys Ala Arg Tyr Leu Gln Val Leu His 
        595                 600                 605             


Cys Cys Ser Leu Asn Arg Asp Leu Glu Leu Leu Pro Phe Gly Asp Met 
    610                 615                 620                 


Thr Glu Ile Gly Glu Arg Gly Leu Asn Leu Ser Gly Gly Gln Lys Gln 
625                 630                 635                 640 


Arg Ile Ser Leu Ala Arg Ala Val Tyr Ser Asp Arg Gln Ile Tyr Leu 
                645                 650                 655     


Leu Asp Asp Pro Leu Ser Ala Val Asp Ala His Val Gly Lys His Ile 
            660                 665                 670         


Phe Glu Glu Cys Ile Lys Lys Thr Leu Arg Gly Lys Thr Val Val Leu 
        675                 680                 685             


Val Thr His Gln Leu Gln Tyr Leu Glu Phe Cys Gly Gln Ile Ile Leu 
    690                 695                 700                 


Leu Glu Asn Gly Lys Ile Cys Glu Asn Gly Thr His Ser Glu Leu Met 
705                 710                 715                 720 


Gln Lys Lys Gly Lys Tyr Ala Gln Leu Ile Gln Lys Met His Lys Glu 
                725                 730                 735     


Ala Thr Ser Asp Met Leu Gln Asp Thr Ala Lys Ile Ala Glu Lys Pro 
            740                 745                 750         


Lys Val Glu Ser Gln Ala Leu Ala Thr Ser Leu Glu Glu Ser Leu Asn 
        755                 760                 765             


Gly Asn Ala Val Pro Glu His Gln Leu Thr Gln Glu Glu Glu Met Glu 
    770                 775                 780                 


Glu Gly Ser Leu Ser Trp Arg Val Tyr His His Tyr Ile Gln Ala Ala 
785                 790                 795                 800 


Gly Gly Tyr Met Val Ser Cys Ile Ile Phe Phe Phe Val Val Leu Ile 
                805                 810                 815     


Val Phe Leu Thr Ile Phe Ser Phe Trp Trp Leu Ser Tyr Trp Leu Glu 
            820                 825                 830         


Gln Gly Ser Gly Thr Asn Ser Ser Arg Glu Ser Asn Gly Thr Met Ala 
        835                 840                 845             


Asp Leu Gly Asn Ile Ala Asp Asn Pro Gln Leu Ser Phe Tyr Gln Leu 
    850                 855                 860                 


Val Tyr Gly Leu Asn Ala Leu Leu Leu Ile Cys Val Gly Val Cys Ser 
865                 870                 875                 880 


Ser Gly Ile Phe Thr Lys Val Thr Arg Lys Ala Ser Thr Ala Leu His 
                885                 890                 895     


Asn Lys Leu Phe Asn Lys Val Phe Arg Cys Pro Met Ser Phe Phe Asp 
            900                 905                 910         


Thr Ile Pro Ile Gly Arg Leu Leu Asn Cys Phe Ala Gly Asp Leu Glu 
        915                 920                 925             


Gln Leu Asp Gln Leu Leu Pro Ile Phe Ser Glu Gln Phe Leu Val Leu 
    930                 935                 940                 


Ser Leu Met Val Ile Ala Val Leu Leu Ile Val Ser Val Leu Ser Pro 
945                 950                 955                 960 


Tyr Ile Leu Leu Met Gly Ala Ile Ile Met Val Ile Cys Phe Ile Tyr 
                965                 970                 975     


Tyr Met Met Phe Lys Lys Ala Ile Gly Val Phe Lys Arg Leu Glu Asn 
            980                 985                 990         


Tyr Ser Arg Ser Pro Leu Phe Ser  His Ile Leu Asn Ser  Leu Gln Gly 
        995                 1000                 1005             


Leu Ser  Ser Ile His Val Tyr  Gly Lys Thr Glu Asp  Phe Ile Ser 
    1010                 1015                 1020             


Gln Phe  Lys Arg Leu Thr Asp  Ala Gln Asn Asn Tyr  Leu Leu Leu 
    1025                 1030                 1035             


Phe Leu  Ser Ser Thr Arg Trp  Met Ala Leu Arg Leu  Glu Ile Met 
    1040                 1045                 1050             


Thr Asn  Leu Val Thr Leu Ala  Val Ala Leu Phe Val  Ala Phe Gly 
    1055                 1060                 1065             


Ile Ser  Ser Thr Pro Tyr Ser  Phe Lys Val Met Ala  Val Asn Ile 
    1070                 1075                 1080             


Val Leu  Gln Leu Ala Ser Ser  Phe Gln Ala Thr Ala  Arg Ile Gly 
    1085                 1090                 1095             


Leu Glu  Thr Glu Ala Gln Phe  Thr Ala Val Glu Arg  Ile Leu Gln 
    1100                 1105                 1110             


Tyr Met  Lys Met Cys Val Ser  Glu Ala Pro Leu His  Met Glu Gly 
    1115                 1120                 1125             


Thr Ser  Cys Pro Gln Gly Trp  Pro Gln His Gly Glu  Ile Ile Phe 
    1130                 1135                 1140             


Gln Asp  Tyr His Met Lys Tyr  Arg Asp Asn Thr Pro  Thr Val Leu 
    1145                 1150                 1155             


His Gly  Ile Asn Leu Thr Ile  Arg Gly His Glu Val  Val Gly Ile 
    1160                 1165                 1170             


Val Gly  Arg Thr Gly Ser Gly  Lys Ser Ser Leu Gly  Met Ala Leu 
    1175                 1180                 1185             


Phe Arg  Leu Val Glu Pro Met  Ala Gly Arg Ile Leu  Ile Asp Gly 
    1190                 1195                 1200             


Val Asp  Ile Cys Ser Ile Gly  Leu Glu Asp Leu Arg  Ser Lys Leu 
    1205                 1210                 1215             


Ser Val  Ile Pro Gln Asp Pro  Val Leu Leu Ser Gly  Thr Ile Arg 
    1220                 1225                 1230             


Phe Asn  Leu Asp Pro Phe Asp  Arg His Thr Asp Gln  Gln Ile Trp 
    1235                 1240                 1245             


Asp Ala  Leu Glu Arg Thr Phe  Leu Thr Lys Ala Ile  Ser Lys Phe 
    1250                 1255                 1260             


Pro Lys  Lys Leu His Thr Asp  Val Val Glu Asn Gly  Gly Asn Phe 
    1265                 1270                 1275             


Ser Val  Gly Glu Arg Gln Leu  Leu Cys Ile Ala Arg  Ala Val Leu 
    1280                 1285                 1290             


Arg Asn  Ser Lys Ile Ile Leu  Ile Asp Glu Ala Thr  Ala Ser Ile 
    1295                 1300                 1305             


Asp Met  Glu Thr Asp Thr Leu  Ile Gln Arg Thr Ile  Arg Glu Ala 
    1310                 1315                 1320             


Phe Gln  Gly Cys Thr Val Leu  Val Ile Ala His Arg  Val Thr Thr 
    1325                 1330                 1335             


Val Leu  Asn Cys Asp His Ile  Leu Val Met Gly Asn  Gly Lys Val 
    1340                 1345                 1350             


Val Glu  Phe Asp Arg Pro Glu  Val Leu Arg Lys Lys  Pro Gly Ser 
    1355                 1360                 1365             


Leu Phe  Ala Ala Leu Met Ala  Thr Ala Thr Ser Ser  Leu Arg 
    1370                 1375                 1380         


<210>  5454
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  5454

Met Gly Gln Asn Asp Leu Met Gly Thr Ala Glu Asp Phe Ala Asp Gln 
1               5                   10                  15      


Phe Leu Arg Val Thr Lys Gln Tyr Leu Pro His Val Ala Arg Leu Cys 
            20                  25                  30          


Leu Ile Ser Thr Phe Leu Glu Asp Gly Ile Arg Met Trp Phe Gln Trp 
        35                  40                  45              


Ser Glu Gln Arg Asp Tyr Ile Asp Thr Thr Trp Asn Cys Gly Tyr Leu 
    50                  55                  60                  


Leu Ala Ser Ser Phe Val Phe Leu Asn Leu Leu Gly Gln Leu Thr Gly 
65                  70                  75                  80  


Cys Val Leu Val Leu Ser Arg Asn Phe Val Gln Tyr Ala Cys Phe Gly 
                85                  90                  95      


Leu Phe Gly Ile Ile Ala Leu Gln Thr Ile Ala Tyr Ser Ile Leu Trp 
            100                 105                 110         


Asp Leu Lys Phe Leu Met Arg Asn Leu Ala Leu Gly Gly Gly Leu Leu 
        115                 120                 125             


Leu Leu Leu Ala Glu Ser Arg Ser Glu Gly Lys Ser Met Phe Ala Gly 
    130                 135                 140                 


Val Pro Thr Met Arg Glu Ser Ser Pro Lys Gln Tyr Met Gln Leu Gly 
145                 150                 155                 160 


Gly Arg Val Leu Leu Val Leu Met Phe Met Thr Leu Leu His Phe Asp 
                165                 170                 175     


Ala Ser Phe Phe Ser Ile Val Gln Asn Ile Val Gly Thr Ala Leu Met 
            180                 185                 190         


Ile Leu Val Ala Ile Gly Phe Lys Thr Lys Leu Ala Ala Leu Thr Leu 
        195                 200                 205             


Val Val Trp Leu Phe Ala Ile Asn Val Tyr Phe Asn Ala Phe Trp Thr 
    210                 215                 220                 


Ile Pro Val Tyr Lys Pro Met His Asp Phe Leu Lys Tyr Asp Phe Phe 
225                 230                 235                 240 


Gln Thr Met Ser Val Ile Gly Gly Leu Leu Leu Val Val Ala Leu Gly 
                245                 250                 255     


Pro Gly Gly Val Ser Met Asp Glu Lys Lys Lys Glu Trp 
            260                 265                 


<210>  5455
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  5455

Met Ala Ser Ala Leu Trp Thr Val Leu Pro Ser Arg Met Ser Leu Arg 
1               5                   10                  15      


Ser Leu Lys Trp Ser Leu Leu Leu Leu Ser Leu Leu Ser Phe Phe Val 
            20                  25                  30          


Met Trp Tyr Leu Ser Leu Pro His Tyr Asn Val Ile Glu Arg Val Asn 
        35                  40                  45              


Trp Met Tyr Phe Tyr Glu Tyr Glu Pro Ile Tyr Arg Gln Asp Phe His 
    50                  55                  60                  


Phe Thr Leu Arg Glu His Ser Asn Cys Ser His Gln Asn Pro Phe Leu 
65                  70                  75                  80  


Val Ile Leu Val Thr Ser His Pro Ser Asp Val Lys Ala Arg Gln Ala 
                85                  90                  95      


Ile Arg Val Thr Trp Gly Glu Lys Lys Ser Trp Trp Gly Tyr Glu Val 
            100                 105                 110         


Leu Thr Phe Phe Leu Leu Gly Gln Glu Ala Glu Lys Glu Asp Lys Met 
        115                 120                 125             


Leu Ala Leu Ser Leu Glu Asp Glu His Leu Leu Tyr Gly Asp Ile Ile 
    130                 135                 140                 


Arg Gln Asp Phe Leu Asp Thr Tyr Asn Asn Leu Thr Leu Lys Thr Ile 
145                 150                 155                 160 


Met Ala Phe Arg Trp Val Thr Glu Phe Cys Pro Asn Ala Lys Tyr Val 
                165                 170                 175     


Met Lys Thr Asp Thr Asp Val Phe Ile Asn Thr Gly Asn Leu Val Lys 
            180                 185                 190         


Tyr Leu Leu Asn Leu Asn His Ser Glu Lys Phe Phe Thr Gly Tyr Pro 
        195                 200                 205             


Leu Ile Asp Asn Tyr Ser Tyr Arg Gly Phe Tyr Gln Lys Thr His Ile 
    210                 215                 220                 


Ser Tyr Gln Glu Tyr Pro Phe Lys Val Phe Pro Pro Tyr Cys Ser Gly 
225                 230                 235                 240 


Leu Gly Tyr Ile Met Ser Arg Asp Leu Val Pro Arg Ile Tyr Glu Met 
                245                 250                 255     


Met Gly His Val Lys Pro Ile Lys Phe Glu Asp Val Tyr Val Gly Ile 
            260                 265                 270         


Cys Leu Asn Leu Leu Lys Val Asn Ile His Ile Pro Glu Asp Thr Asn 
        275                 280                 285             


Leu Phe Phe Leu Tyr Arg Ile His Leu Asp Val Cys Gln Leu Arg Arg 
    290                 295                 300                 


Val Ile Ala Ala His Gly Phe Ser Ser Lys Glu Ile Ile Thr Phe Trp 
305                 310                 315                 320 


Gln Val Met Leu Arg Asn Thr Thr Cys His Tyr 
                325                 330     


<210>  5456
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  5456

Met Ala Ser Ala Leu Trp Thr Val Leu Pro Ser Arg Met Ser Leu Arg 
1               5                   10                  15      


Ser Leu Lys Trp Ser Leu Leu Leu Leu Ser Leu Leu Ser Phe Phe Val 
            20                  25                  30          


Met Trp Tyr Leu Ser Leu Pro His Tyr Asn Val Ile Glu Arg Val Asn 
        35                  40                  45              


Trp Met Tyr Phe Tyr Glu Tyr Glu Pro Ile Tyr Arg Gln Asp Phe His 
    50                  55                  60                  


Phe Thr Leu Arg Glu His Ser Asn Cys Ser His Gln Asn Pro Phe Leu 
65                  70                  75                  80  


Val Ile Leu Val Thr Ser His Pro Ser Asp Val Lys Ala Arg Gln Ala 
                85                  90                  95      


Ile Arg Val Thr Trp Gly Glu Lys Lys Ser Trp Trp Gly Tyr Glu Val 
            100                 105                 110         


Leu Thr Phe Phe Leu Leu Gly Gln Glu Ala Glu Lys Glu Asp Lys Met 
        115                 120                 125             


Leu Ala Leu Ser Leu Glu Asp Glu His Leu Leu Tyr Gly Asp Ile Ile 
    130                 135                 140                 


Arg Gln Asp Phe Leu Asp Thr Tyr Asn Asn Leu Thr Leu Lys Thr Ile 
145                 150                 155                 160 


Met Ala Phe Arg Trp Val Thr Glu Phe Cys Pro Asn Ala Lys Tyr Val 
                165                 170                 175     


Met Lys Thr Asp Thr Asp Val Phe Ile Asn Thr Gly Asn Leu Val Lys 
            180                 185                 190         


Tyr Leu Leu Asn Leu Asn His Ser Glu Lys Phe Phe Thr Gly Tyr Pro 
        195                 200                 205             


Leu Ile Asp Asn Tyr Ser Tyr Arg Gly Phe Tyr Gln Lys Thr His Ile 
    210                 215                 220                 


Ser Tyr Gln Glu Tyr Pro Phe Lys Val Phe Pro Pro Tyr Cys Ser Gly 
225                 230                 235                 240 


Leu Gly Tyr Ile Met Ser Arg Asp Leu Val Pro Arg Ile Tyr Glu Met 
                245                 250                 255     


Met Gly His Val Lys Pro Ile Lys Phe Glu Asp Val Tyr Val Gly Ile 
            260                 265                 270         


Cys Leu Asn Leu Leu Lys Val Asn Ile His Ile Pro Glu Asp Thr Asn 
        275                 280                 285             


Leu Phe Phe Leu Tyr Arg Ile His Leu Asp Val Cys Gln Leu Arg Arg 
    290                 295                 300                 


Val Ile Ala Ala His Gly Phe Ser Ser Lys Glu Ile Ile Thr Phe Trp 
305                 310                 315                 320 


Gln Val Met Leu Arg Asn Thr Thr Cys His Tyr 
                325                 330     


<210>  5457
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  5457

Met Ala Ser Ala Leu Trp Thr Val Leu Pro Ser Arg Met Ser Leu Arg 
1               5                   10                  15      


Ser Leu Lys Trp Ser Leu Leu Leu Leu Ser Leu Leu Ser Phe Phe Val 
            20                  25                  30          


Met Trp Tyr Leu Ser Leu Pro His Tyr Asn Val Ile Glu Arg Val Asn 
        35                  40                  45              


Trp Met Tyr Phe Tyr Glu Tyr Glu Pro Ile Tyr Arg Gln Asp Phe His 
    50                  55                  60                  


Phe Thr Leu Arg Glu His Ser Asn Cys Ser His Gln Asn Pro Phe Leu 
65                  70                  75                  80  


Val Ile Leu Val Thr Ser His Pro Ser Asp Val Lys Ala Arg Gln Ala 
                85                  90                  95      


Ile Arg Val Thr Trp Gly Glu Lys Lys Ser Trp Trp Gly Tyr Glu Val 
            100                 105                 110         


Leu Thr Phe Phe Leu Leu Gly Gln Glu Ala Glu Lys Glu Asp Lys Met 
        115                 120                 125             


Leu Ala Leu Ser Leu Glu Asp Glu His Leu Leu Tyr Gly Asp Ile Ile 
    130                 135                 140                 


Arg Gln Asp Phe Leu Asp Thr Tyr Asn Asn Leu Thr Leu Lys Thr Ile 
145                 150                 155                 160 


Met Ala Phe Arg Trp Val Thr Glu Phe Cys Pro Asn Ala Lys Tyr Val 
                165                 170                 175     


Met Lys Thr Asp Thr Asp Val Phe Ile Asn Thr Gly Asn Leu Val Lys 
            180                 185                 190         


Tyr Leu Leu Asn Leu Asn His Ser Glu Lys Phe Phe Thr Gly Tyr Pro 
        195                 200                 205             


Leu Ile Asp Asn Tyr Ser Tyr Arg Gly Phe Tyr Gln Lys Thr His Ile 
    210                 215                 220                 


Ser Tyr Gln Glu Tyr Pro Phe Lys Val Phe Pro Pro Tyr Cys Ser Gly 
225                 230                 235                 240 


Leu Gly Tyr Ile Met Ser Arg Asp Leu Val Pro Arg Ile Tyr Glu Met 
                245                 250                 255     


Met Gly His Val Lys Pro Ile Lys Phe Glu Asp Val Tyr Val Gly Ile 
            260                 265                 270         


Cys Leu Asn Leu Leu Lys Val Asn Ile His Ile Pro Glu Asp Thr Asn 
        275                 280                 285             


Leu Phe Phe Leu Tyr Arg Ile His Leu Asp Val Cys Gln Leu Arg Arg 
    290                 295                 300                 


Val Ile Ala Ala His Gly Phe Ser Ser Lys Glu Ile Ile Thr Phe Trp 
305                 310                 315                 320 


Gln Val Met Leu Arg Asn Thr Thr Cys His Tyr 
                325                 330     


<210>  5458
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  5458

Met Ala Phe Pro Lys Met Arg Leu Met Tyr Ile Cys Leu Leu Val Leu 
1               5                   10                  15      


Gly Ala Leu Cys Leu Tyr Phe Ser Met Tyr Ser Leu Asn Pro Phe Lys 
            20                  25                  30          


Glu Gln Ser Phe Val Tyr Lys Lys Asp Gly Asn Phe Leu Lys Leu Pro 
        35                  40                  45              


Asp Thr Asp Cys Arg Gln Thr Pro Pro Phe Leu Val Leu Leu Val Thr 
    50                  55                  60                  


Ser Ser His Lys Gln Leu Ala Glu Arg Met Ala Ile Arg Gln Thr Trp 
65                  70                  75                  80  


Gly Lys Glu Arg Met Val Lys Gly Lys Gln Leu Lys Thr Phe Phe Leu 
                85                  90                  95      


Leu Gly Thr Thr Ser Ser Ala Ala Glu Thr Lys Glu Val Asp Gln Glu 
            100                 105                 110         


Ser Gln Arg His Gly Asp Ile Ile Gln Lys Asp Phe Leu Asp Val Tyr 
        115                 120                 125             


Tyr Asn Leu Thr Leu Lys Thr Met Met Gly Ile Glu Trp Val His Arg 
    130                 135                 140                 


Phe Cys Pro Gln Ala Ala Phe Val Met Lys Thr Asp Ser Asp Met Phe 
145                 150                 155                 160 


Ile Asn Val Asp Tyr Leu Thr Glu Leu Leu Leu Lys Lys Asn Arg Thr 
                165                 170                 175     


Thr Arg Phe Phe Thr Gly Phe Leu Lys Leu Asn Glu Phe Pro Ile Arg 
            180                 185                 190         


Gln Pro Phe Ser Lys Trp Phe Val Ser Lys Ser Glu Tyr Pro Trp Asp 
        195                 200                 205             


Arg Tyr Pro Pro Phe Cys Ser Gly Thr Gly Tyr Val Phe Ser Gly Asp 
    210                 215                 220                 


Val Ala Ser Gln Val Tyr Asn Val Ser Lys Ser Val Pro Tyr Ile Lys 
225                 230                 235                 240 


Leu Glu Asp Val Phe Val Gly Leu Cys Leu Glu Arg Leu Asn Ile Arg 
                245                 250                 255     


Leu Glu Glu Leu His Ser Gln Pro Thr Phe Phe Pro Gly Gly Leu Arg 
            260                 265                 270         


Phe Ser Val Cys Leu Phe Arg Arg Ile Val Ala Cys His Phe Ile Lys 
        275                 280                 285             


Pro Arg Thr Leu Leu Asp Tyr Trp Gln Ala Leu Glu Asn Ser Arg Gly 
    290                 295                 300                 


Glu Asp Cys Pro Pro Val 
305                 310 


<210>  5459
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  5459

Met Ala Phe Pro Lys Met Arg Leu Met Tyr Ile Cys Leu Leu Val Leu 
1               5                   10                  15      


Gly Ala Leu Cys Leu Tyr Phe Ser Met Tyr Ser Leu Asn Pro Phe Lys 
            20                  25                  30          


Glu Gln Ser Phe Val Tyr Lys Lys Asp Gly Asn Phe Leu Lys Leu Pro 
        35                  40                  45              


Asp Thr Asp Cys Arg Gln Thr Pro Pro Phe Leu Val Leu Leu Val Thr 
    50                  55                  60                  


Ser Ser His Lys Gln Leu Ala Glu Arg Met Ala Ile Arg Gln Thr Trp 
65                  70                  75                  80  


Gly Lys Glu Arg Met Val Lys Gly Lys Gln Leu Lys Thr Phe Phe Leu 
                85                  90                  95      


Leu Gly Thr Thr Ser Ser Ala Ala Glu Thr Lys Glu Val Asp Gln Glu 
            100                 105                 110         


Ser Gln Arg His Gly Asp Ile Ile Gln Lys Asp Phe Leu Asp Val Tyr 
        115                 120                 125             


Tyr Asn Leu Thr Leu Lys Thr Met Met Gly Ile Glu Trp Val His Arg 
    130                 135                 140                 


Phe Cys Pro Gln Ala Ala Phe Val Met Lys Thr Asp Ser Asp Met Phe 
145                 150                 155                 160 


Ile Asn Val Asp Tyr Leu Thr Glu Leu Leu Leu Lys Lys Asn Arg Thr 
                165                 170                 175     


Thr Arg Phe Phe Thr Gly Phe Leu Lys Leu Asn Glu Phe Pro Ile Arg 
            180                 185                 190         


Gln Pro Phe Ser Lys Trp Phe Val Ser Lys Ser Glu Tyr Pro Trp Asp 
        195                 200                 205             


Arg Tyr Pro Pro Phe Cys Ser Gly Thr Gly Tyr Val Phe Ser Gly Asp 
    210                 215                 220                 


Val Ala Ser Gln Val Tyr Asn Val Ser Lys Ser Val Pro Tyr Ile Lys 
225                 230                 235                 240 


Leu Glu Asp Val Phe Val Gly Leu Cys Leu Glu Arg Leu Asn Ile Arg 
                245                 250                 255     


Leu Glu Glu Leu His Ser Gln Pro Thr Phe Phe Pro Gly Gly Leu Arg 
            260                 265                 270         


Phe Ser Val Cys Leu Phe Arg Arg Ile Val Ala Cys His Phe Ile Lys 
        275                 280                 285             


Pro Arg Thr Leu Leu Asp Tyr Trp Gln Ala Leu Glu Asn Ser Arg Gly 
    290                 295                 300                 


Glu Asp Cys Pro Pro Val 
305                 310 


<210>  5460
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  5460

Met Cys Leu Glu Met Ala Phe Pro Lys Met Arg Leu Met Tyr Ile Cys 
1               5                   10                  15      


Leu Leu Val Leu Gly Ala Leu Cys Leu Tyr Phe Ser Met Tyr Ser Leu 
            20                  25                  30          


Asn Pro Phe Lys Glu Gln Ser Phe Val Tyr Lys Lys Asp Gly Asn Phe 
        35                  40                  45              


Leu Lys Leu Pro Asp Thr Asp Cys Arg Gln Thr Pro Pro Phe Leu Val 
    50                  55                  60                  


Leu Leu Val Thr Ser Ser His Lys Gln Leu Ala Glu Arg Met Ala Ile 
65                  70                  75                  80  


Arg Gln Thr Trp Gly Lys Glu Arg Met Val Lys Gly Lys Gln Leu Lys 
                85                  90                  95      


Thr Phe Phe Leu Leu Gly Thr Thr Ser Ser Ala Ala Glu Thr Lys Glu 
            100                 105                 110         


Val Asp Gln Glu Ser Gln Arg His Gly Asp Ile Ile Gln Lys Asp Phe 
        115                 120                 125             


Leu Asp Val Tyr Tyr Asn Leu Thr Leu Lys Thr Met Met Gly Ile Glu 
    130                 135                 140                 


Trp Val His Arg Phe Cys Pro Gln Ala Ala Phe Val Met Lys Thr Asp 
145                 150                 155                 160 


Ser Asp Met Phe Ile Asn Val Asp Tyr Leu Thr Glu Leu Leu Leu Lys 
                165                 170                 175     


Lys Asn Arg Thr Thr Arg Phe Phe Thr Gly Phe Leu Lys Leu Asn Glu 
            180                 185                 190         


Phe Pro Ile Arg Gln Pro Phe Ser Lys Trp Phe Val Ser Lys Ser Glu 
        195                 200                 205             


Tyr Pro Trp Asp Arg Tyr Pro Pro Phe Cys Ser Gly Thr Gly Tyr Val 
    210                 215                 220                 


Phe Ser Gly Asp Val Ala Ser Gln Val Tyr Asn Val Ser Lys Ser Val 
225                 230                 235                 240 


Pro Tyr Ile Lys Leu Glu Asp Val Phe Val Gly Leu Cys Leu Glu Arg 
                245                 250                 255     


Leu Asn Ile Arg Leu Glu Glu Leu His Ser Gln Pro Thr Phe Phe Pro 
            260                 265                 270         


Gly Gly Leu Arg Phe Ser Val Cys Leu Phe Arg Arg Ile Val Ala Cys 
        275                 280                 285             


His Phe Ile Lys Pro Arg Thr Leu Leu Asp Tyr Trp Gln Ala Leu Glu 
    290                 295                 300                 


Asn Ser Arg Gly Glu Asp Cys Pro Pro Val 
305                 310                 


<210>  5461
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  5461

Met Cys Leu Glu Met Ala Phe Pro Lys Met Arg Leu Met Tyr Ile Cys 
1               5                   10                  15      


Leu Leu Val Leu Gly Ala Leu Cys Leu Tyr Phe Ser Met Tyr Ser Leu 
            20                  25                  30          


Asn Pro Phe Lys Glu Gln Ser Phe Val Tyr Lys Lys Asp Gly Asn Phe 
        35                  40                  45              


Leu Lys Leu Pro Asp Thr Asp Cys Arg Gln Thr Pro Pro Phe Leu Val 
    50                  55                  60                  


Leu Leu Val Thr Ser Ser His Lys Gln Leu Ala Glu Arg Met Ala Ile 
65                  70                  75                  80  


Arg Gln Thr Trp Gly Lys Glu Arg Met Val Lys Gly Lys Gln Leu Lys 
                85                  90                  95      


Thr Phe Phe Leu Leu Gly Thr Thr Ser Ser Ala Ala Glu Thr Lys Glu 
            100                 105                 110         


Val Asp Gln Glu Ser Gln Arg His Gly Asp Ile Ile Gln Lys Asp Phe 
        115                 120                 125             


Leu Asp Val Tyr Tyr Asn Leu Thr Leu Lys Thr Met Met Gly Ile Glu 
    130                 135                 140                 


Trp Val His Arg Phe Cys Pro Gln Ala Ala Phe Val Met Lys Thr Asp 
145                 150                 155                 160 


Ser Asp Met Phe Ile Asn Val Asp Tyr Leu Thr Glu Leu Leu Leu Lys 
                165                 170                 175     


Lys Asn Arg Thr Thr Arg Phe Phe Thr Gly Phe Leu Lys Leu Asn Glu 
            180                 185                 190         


Phe Pro Ile Arg Gln Pro Phe Ser Lys Trp Phe Val Ser Lys Ser Glu 
        195                 200                 205             


Tyr Pro Trp Asp Arg Tyr Pro Pro Phe Cys Ser Gly Thr Gly Tyr Val 
    210                 215                 220                 


Phe Ser Gly Asp Val Ala Ser Gln Val Tyr Asn Val Ser Lys Ser Val 
225                 230                 235                 240 


Pro Tyr Ile Lys Leu Glu Asp Val Phe Val Gly Leu Cys Leu Glu Arg 
                245                 250                 255     


Leu Asn Ile Arg Leu Glu Glu Leu His Ser Gln Pro Thr Phe Phe Pro 
            260                 265                 270         


Gly Gly Leu Arg Phe Ser Val Cys Leu Phe Arg Arg Ile Val Ala Cys 
        275                 280                 285             


His Phe Ile Lys Pro Arg Thr Leu Leu Asp Tyr Trp Gln Ala Leu Glu 
    290                 295                 300                 


Asn Ser Arg Gly Glu Asp Cys Pro Pro Val 
305                 310                 


<210>  5462
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  5462

Met Trp Tyr Asn Asn Ser Ala Gly Pro Phe Leu Leu Thr Gly Phe Leu 
1               5                   10                  15      


Gly Ser Glu Ala Val His Tyr Arg Ile Ser Met Ser Phe Phe Val Ile 
            20                  25                  30          


Tyr Phe Ser Val Leu Phe Gly Asn Gly Thr Leu Leu Val Leu Ile Trp 
        35                  40                  45              


Asn Asp His Ser Leu His Glu Pro Met Tyr Tyr Phe Leu Ala Met Leu 
    50                  55                  60                  


Ala Asp Thr Asp Leu Gly Met Thr Phe Thr Thr Met Pro Thr Val Leu 
65                  70                  75                  80  


Gly Val Leu Leu Leu Asp Gln Arg Glu Ile Ala His Ala Ala Cys Phe 
                85                  90                  95      


Thr Gln Ser Phe Ile His Ser Leu Ala Ile Val Glu Ser Gly Ile Leu 
            100                 105                 110         


Leu Val Leu Ala Tyr Asp Cys Phe Ile Ala Ile Arg Thr Pro Leu Arg 
        115                 120                 125             


Tyr Asn Cys Ile Leu Thr Asn Ser Arg Val Met Asn Ile Gly Leu Gly 
    130                 135                 140                 


Val Leu Met Arg Gly Phe Met Ser Ile Leu Pro Ile Ile Leu Ser Leu 
145                 150                 155                 160 


Tyr Cys Tyr Pro Tyr Cys Gly Ser Arg Ala Leu Leu His Thr Phe Cys 
                165                 170                 175     


Leu His Gln Asp Val Ile Lys Leu Ala Cys Ala Asp Ile Thr Phe Asn 
            180                 185                 190         


His Ile Tyr Pro Ile Ile Gln Thr Ser Leu Thr Val Phe Leu Asp Ala 
        195                 200                 205             


Leu Ile Ile Ile Phe Ser Tyr Ile Leu Ile Leu Lys Thr Val Met Gly 
    210                 215                 220                 


Ile Ala Ser Gly Gln Glu Glu Ala Lys Ser Leu Asn Thr Cys Val Ser 
225                 230                 235                 240 


His Ile Ser Cys Val Leu Val Phe His Ile Thr Val Met Gly Leu Ser 
                245                 250                 255     


Phe Ile His Arg Phe Gly Lys His Ala Pro His Val Val Pro Ile Thr 
            260                 265                 270         


Met Ser Tyr Val His Phe Leu Phe Pro Pro Phe Val Asn Pro Ile Ile 
        275                 280                 285             


Tyr Ser Ile Lys Thr Lys Gln Ile Gln Arg Ser Ile Ile Arg Leu Phe 
    290                 295                 300                 


Ser Gly Gln Ser Arg Ala 
305                 310 


<210>  5463
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  5463

Met Trp Pro Asn Ile Thr Ala Ala Pro Phe Leu Leu Thr Gly Phe Pro 
1               5                   10                  15      


Gly Leu Glu Ala Ala His His Trp Ile Ser Ile Pro Phe Phe Ala Val 
            20                  25                  30          


Tyr Val Cys Ile Leu Leu Gly Asn Gly Met Leu Leu Tyr Leu Ile Lys 
        35                  40                  45              


His Asp His Ser Leu His Glu Pro Met Tyr Tyr Phe Leu Thr Met Leu 
    50                  55                  60                  


Ala Gly Thr Asp Leu Met Val Thr Leu Thr Thr Met Pro Thr Val Met 
65                  70                  75                  80  


Gly Ile Leu Trp Val Asn His Arg Glu Ile Ser Ser Val Gly Cys Phe 
                85                  90                  95      


Leu Gln Ala Tyr Phe Ile His Ser Leu Ser Val Val Glu Ser Gly Ser 
            100                 105                 110         


Leu Leu Ala Met Ala Tyr Asp Cys Phe Ile Ala Ile Arg Asn Pro Leu 
        115                 120                 125             


Arg Tyr Ala Ser Ile Leu Thr Asn Thr Arg Val Ile Ala Leu Gly Val 
    130                 135                 140                 


Gly Val Phe Leu Arg Gly Phe Val Ser Ile Leu Pro Val Ile Leu Arg 
145                 150                 155                 160 


Leu Phe Ser Phe Ser Tyr Cys Lys Ser His Val Ile Thr Arg Ala Phe 
                165                 170                 175     


Cys Leu His Gln Glu Ile Met Arg Leu Ala Cys Ala Asp Ile Thr Phe 
            180                 185                 190         


Asn Arg Leu Tyr Pro Val Ile Leu Ile Ser Leu Thr Ile Phe Leu Asp 
        195                 200                 205             


Cys Leu Ile Ile Leu Phe Ser Tyr Ile Leu Ile Leu Asn Thr Val Ile 
    210                 215                 220                 


Gly Ile Ala Ser Gly Glu Glu Arg Ala Lys Ala Leu Asn Thr Cys Ile 
225                 230                 235                 240 


Ser His Ile Ser Cys Val Leu Ile Phe Tyr Val Thr Val Met Gly Leu 
                245                 250                 255     


Thr Phe Ile Tyr Arg Phe Gly Lys Asn Val Pro Glu Val Val His Ile 
            260                 265                 270         


Ile Met Ser Tyr Ile Tyr Phe Leu Phe Pro Pro Leu Met Asn Pro Val 
        275                 280                 285             


Ile Tyr Ser Ile Lys Thr Lys Gln Ile Gln Tyr Gly Ile Ile Arg Leu 
    290                 295                 300                 


Leu Ser Lys His Arg Phe Ser Ser 
305                 310         


<210>  5464
<211>  439
<212>  PRT
<213>  Homo sapiens

<400>  5464

Met Lys Ser Ile Leu Asp Gly Leu Ala Asp Thr Thr Phe Arg Thr Ile 
1               5                   10                  15      


Thr Thr Asp Leu Leu Gly Ser Pro Phe Gln Glu Lys Met Thr Ala Gly 
            20                  25                  30          


Asp Asn Pro Gln Leu Val Pro Ala Asp Gln Val Asn Ile Thr Glu Phe 
        35                  40                  45              


Tyr Asn Lys Ser Leu Ser Ser Phe Lys Glu Asn Glu Glu Asn Ile Gln 
    50                  55                  60                  


Cys Gly Glu Asn Phe Met Asp Ile Glu Cys Phe Met Val Leu Asn Pro 
65                  70                  75                  80  


Ser Gln Gln Leu Ala Ile Ala Val Leu Ser Leu Thr Leu Gly Thr Phe 
                85                  90                  95      


Thr Val Leu Glu Asn Leu Leu Val Leu Cys Val Ile Leu His Ser Arg 
            100                 105                 110         


Ser Leu Arg Cys Arg Pro Ser Tyr His Phe Ile Gly Ser Leu Ala Val 
        115                 120                 125             


Ala Asp Leu Leu Gly Ser Val Ile Phe Val Tyr Ser Phe Ile Asp Phe 
    130                 135                 140                 


His Val Phe His Arg Lys Asp Ser Arg Asn Val Phe Leu Phe Lys Leu 
145                 150                 155                 160 


Gly Gly Val Thr Ala Ser Phe Thr Ala Ser Val Gly Ser Leu Phe Leu 
                165                 170                 175     


Thr Ala Ile Asp Arg Tyr Ile Ser Ile His Arg Pro Leu Ala Tyr Lys 
            180                 185                 190         


Arg Ile Val Thr Arg Pro Lys Ala Val Val Ala Phe Cys Leu Met Trp 
        195                 200                 205             


Thr Ile Ala Ile Val Ile Ala Val Leu Pro Leu Leu Gly Trp Asn Cys 
    210                 215                 220                 


Glu Lys Leu Gln Ser Val Cys Ser Asp Ile Phe Pro His Ile Asp Glu 
225                 230                 235                 240 


Thr Tyr Leu Met Phe Trp Ile Gly Val Thr Ser Val Leu Leu Leu Phe 
                245                 250                 255     


Ile Val Tyr Ala Tyr Met Tyr Ile Leu Trp Lys Ala His Ser His Ala 
            260                 265                 270         


Val Arg Met Ile Gln Arg Gly Thr Gln Lys Ser Ile Ile Ile His Thr 
        275                 280                 285             


Ser Glu Asp Gly Lys Val Gln Val Thr Arg Pro Asp Gln Ala Arg Met 
    290                 295                 300                 


Asp Ile Arg Leu Ala Lys Thr Leu Val Leu Ile Leu Val Val Leu Ile 
305                 310                 315                 320 


Ile Cys Trp Gly Pro Leu Leu Ala Ile Met Val Tyr Asp Val Phe Gly 
                325                 330                 335     


Lys Met Asn Lys Leu Ile Lys Thr Val Phe Ala Phe Cys Ser Met Leu 
            340                 345                 350         


Cys Leu Leu Asn Ser Thr Val Asn Pro Ile Ile Tyr Ala Leu Arg Ser 
        355                 360                 365             


Lys Asp Leu Arg His Ala Phe Arg Ser Met Phe Pro Ser Cys Glu Gly 
    370                 375                 380                 


Thr Ala Gln Pro Leu Asp Asn Ser Met Gly Asp Ser Asp Cys Leu His 
385                 390                 395                 400 


Lys His Ala Asn Asn Ala Ala Ser Val His Arg Ala Ala Glu Ser Cys 
                405                 410                 415     


Ile Lys Ser Thr Val Lys Ile Ala Lys Val Thr Met Ser Val Ser Thr 
            420                 425                 430         


Asp Thr Ser Ala Glu Ala Leu 
        435                 


<210>  5465
<211>  484
<212>  PRT
<213>  Homo sapiens

<400>  5465

Met Ala Gly Pro Trp Thr Phe Thr Leu Leu Cys Gly Leu Leu Ala Ala 
1               5                   10                  15      


Thr Leu Ile Gln Ala Thr Leu Ser Pro Thr Ala Val Leu Ile Leu Gly 
            20                  25                  30          


Pro Lys Val Ile Lys Glu Lys Leu Thr Gln Glu Leu Lys Asp His Asn 
        35                  40                  45              


Ala Thr Ser Ile Leu Gln Gln Leu Pro Leu Leu Ser Ala Met Arg Glu 
    50                  55                  60                  


Lys Pro Ala Gly Gly Ile Pro Val Leu Gly Ser Leu Val Asn Thr Val 
65                  70                  75                  80  


Leu Lys His Ile Ile Trp Leu Lys Val Ile Thr Ala Asn Ile Leu Gln 
                85                  90                  95      


Leu Gln Val Lys Pro Ser Ala Asn Asp Gln Glu Leu Leu Val Lys Ile 
            100                 105                 110         


Pro Leu Asp Met Val Ala Gly Phe Asn Thr Pro Leu Val Lys Thr Ile 
        115                 120                 125             


Val Glu Phe His Met Thr Thr Glu Ala Gln Ala Thr Ile Arg Met Asp 
    130                 135                 140                 


Thr Ser Ala Ser Gly Pro Thr Arg Leu Val Leu Ser Asp Cys Ala Thr 
145                 150                 155                 160 


Ser His Gly Ser Leu Arg Ile Gln Leu Leu His Lys Leu Ser Phe Leu 
                165                 170                 175     


Val Asn Ala Leu Ala Lys Gln Val Met Asn Leu Leu Val Pro Ser Leu 
            180                 185                 190         


Pro Asn Leu Val Lys Asn Gln Leu Cys Pro Val Ile Glu Ala Ser Phe 
        195                 200                 205             


Asn Gly Met Tyr Ala Asp Leu Leu Gln Leu Val Lys Val Pro Ile Ser 
    210                 215                 220                 


Leu Ser Ile Asp Arg Leu Glu Phe Asp Leu Leu Tyr Pro Ala Ile Lys 
225                 230                 235                 240 


Gly Asp Thr Ile Gln Leu Tyr Leu Gly Ala Lys Leu Leu Asp Ser Gln 
                245                 250                 255     


Gly Lys Val Thr Lys Trp Phe Asn Asn Ser Ala Ala Ser Leu Thr Met 
            260                 265                 270         


Pro Thr Leu Asp Asn Ile Pro Phe Ser Leu Ile Val Ser Gln Asp Val 
        275                 280                 285             


Val Lys Ala Ala Val Ala Ala Val Leu Ser Pro Glu Glu Phe Met Val 
    290                 295                 300                 


Leu Leu Asp Ser Val Leu Pro Glu Ser Ala His Arg Leu Lys Ser Ser 
305                 310                 315                 320 


Ile Gly Leu Ile Asn Glu Lys Ala Ala Asp Lys Leu Gly Ser Thr Gln 
                325                 330                 335     


Ile Val Lys Ile Leu Thr Gln Asp Thr Pro Glu Phe Phe Ile Asp Gln 
            340                 345                 350         


Gly His Ala Lys Val Ala Gln Leu Ile Val Leu Glu Val Phe Pro Ser 
        355                 360                 365             


Ser Glu Ala Leu Arg Pro Leu Phe Thr Leu Gly Ile Glu Ala Ser Ser 
    370                 375                 380                 


Glu Ala Gln Phe Tyr Thr Lys Gly Asp Gln Leu Ile Leu Asn Leu Asn 
385                 390                 395                 400 


Asn Ile Ser Ser Asp Arg Ile Gln Leu Met Asn Ser Gly Ile Gly Trp 
                405                 410                 415     


Phe Gln Pro Asp Val Leu Lys Asn Ile Ile Thr Glu Ile Ile His Ser 
            420                 425                 430         


Ile Leu Leu Pro Asn Gln Asn Gly Lys Leu Arg Ser Gly Val Pro Val 
        435                 440                 445             


Ser Leu Val Lys Ala Leu Gly Phe Glu Ala Ala Glu Ser Ser Leu Thr 
    450                 455                 460                 


Lys Asp Ala Leu Val Leu Thr Pro Ala Ser Leu Trp Lys Pro Ser Ser 
465                 470                 475                 480 


Pro Val Ser Gln 
                


<210>  5466
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  5466

Met Ala Ala Ala Gly Ala Ala Ala Thr His Leu Glu Val Ala Arg Gly 
1               5                   10                  15      


Lys Arg Ala Ala Leu Phe Phe Ala Ala Val Ala Ile Val Leu Gly Leu 
            20                  25                  30          


Pro Leu Trp Trp Lys Thr Thr Glu Thr Tyr Arg Ala Ser Leu Pro Tyr 
        35                  40                  45              


Ser Gln Ile Ser Gly Leu Asn Ala Leu Gln Leu Arg Leu Met Val Pro 
    50                  55                  60                  


Val Thr Val Val Phe Thr Arg Glu Ser Val Pro Leu Asp Asp Gln Glu 
65                  70                  75                  80  


Lys Leu Pro Phe Thr Val Val His Glu Arg Glu Ile Pro Leu Lys Tyr 
                85                  90                  95      


Lys Met Lys Ile Lys Cys Arg Phe Gln Lys Ala Tyr Arg Arg Ala Leu 
            100                 105                 110         


Asp His Glu Glu Glu Ala Leu Ser Ser Gly Ser Val Gln Glu Ala Glu 
        115                 120                 125             


Ala Met Leu Asp Glu Pro Gln Glu Gln Ala Glu Gly Ser Leu Thr Val 
    130                 135                 140                 


Tyr Val Ile Ser Glu His Ser Ser Leu Leu Pro Gln Asp Met Met Ser 
145                 150                 155                 160 


Tyr Ile Gly Pro Lys Arg Thr Ala Val Val Arg Gly Ile Met His Arg 
                165                 170                 175     


Glu Ala Phe Asn Ile Ile Gly Arg Arg Ile Val Gln Val Ala Gln Ala 
            180                 185                 190         


Met Ser Leu Thr Glu Asp Val Leu Ala Ala Ala Leu Ala Asp His Leu 
        195                 200                 205             


Pro Glu Asp Lys Trp Ser Ala Glu Lys Arg Arg Pro Leu Lys Ser Ser 
    210                 215                 220                 


Leu Gly Tyr Glu Ile Thr Phe Ser Leu Leu Asn Pro Asp Pro Lys Ser 
225                 230                 235                 240 


His Asp Val Tyr Trp Asp Ile Glu Gly Ala Val Arg Arg Tyr Val Gln 
                245                 250                 255     


Pro Phe Leu Asn Ala Leu Gly Ala Ala Gly Asn Phe Ser Val Asp Ser 
            260                 265                 270         


Gln Ile Leu Tyr Tyr Ala Met Leu Gly Val Asn Pro Arg Phe Asp Ser 
        275                 280                 285             


Ala Ser Ser Ser Tyr Tyr Leu Asp Met His Ser Leu Pro His Val Ile 
    290                 295                 300                 


Asn Pro Val Glu Ser Arg Leu Gly Ser Ser Ala Ala Ser Leu Tyr Pro 
305                 310                 315                 320 


Val Leu Asn Phe Leu Leu Tyr Val Pro Glu Leu Ala His Ser Pro Leu 
                325                 330                 335     


Tyr Ile Gln Asp Lys Asp Gly Ala Pro Val Ala Thr Asn Ala Phe His 
            340                 345                 350         


Ser Pro Arg Trp Gly Gly Ile Met Val Tyr Asn Val Asp Ser Lys Thr 
        355                 360                 365             


Tyr Asn Ala Ser Val Leu Pro Val Arg Val Glu Val Asp Met Val Arg 
    370                 375                 380                 


Val Met Glu Val Phe Leu Ala Gln Leu Arg Leu Leu Phe Gly Ile Ala 
385                 390                 395                 400 


Gln Pro Gln Leu Pro Pro Lys Cys Leu Leu Ser Gly Pro Thr Ser Glu 
                405                 410                 415     


Gly Leu Met Thr Trp Glu Leu Asp Arg Leu Leu Trp Ala Arg Ser Val 
            420                 425                 430         


Glu Asn Leu Ala Thr Ala Thr Thr Thr Leu Thr Ser Leu Ala Gln Leu 
        435                 440                 445             


Leu Gly Lys Ile Ser Asn Ile Val Ile Lys Asp Asp Val Ala Ser Glu 
    450                 455                 460                 


Val Tyr Lys Ala Val Ala Ala Val Gln Lys Ser Ala Glu Glu Leu Ala 
465                 470                 475                 480 


Ser Gly His Leu Ala Ser Ala Phe Val Ala Ser Gln Glu Ala Val Thr 
                485                 490                 495     


Ser Ser Glu Leu Ala Phe Phe Asp Pro Ser Leu Leu His Leu Leu Tyr 
            500                 505                 510         


Phe Pro Asp Asp Gln Lys Phe Ala Ile Tyr Ile Pro Leu Phe Leu Pro 
        515                 520                 525             


Met Ala Val Pro Ile Leu Leu Ser Leu Val Lys Ile Phe Leu Glu Thr 
    530                 535                 540                 


Arg Lys Ser Trp Arg Lys Pro Glu Lys Thr Asp 
545                 550                 555 


<210>  5467
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  5467

Met Thr Arg Cys Ala Leu Leu Leu Leu Met Val Leu Met Leu Gly Arg 
1               5                   10                  15      


Val Leu Val Val Pro Val Thr Pro Ile Pro Thr Phe Gln Leu Arg Pro 
            20                  25                  30          


Gln Asn Ser Pro Gln Thr Thr Pro Arg Pro Ala Ala Ser Glu Ser Pro 
        35                  40                  45              


Ser Ala Ala Pro Thr Trp Pro Trp Ala Ala Gln Ser His Cys Ser Pro 
    50                  55                  60                  


Thr Arg His Pro Gly Ser Arg Ile Val Leu Ser Leu Asp Val Pro Ile 
65                  70                  75                  80  


Gly Leu Leu Gln Ile Leu Leu Glu Gln Ala Arg Ala Arg Ala Ala Arg 
                85                  90                  95      


Glu Gln Ala Thr Thr Asn Ala Arg Ile Leu Ala Arg Val Gly His Cys 
            100                 105                 110         


<210>  5468
<211>  707
<212>  PRT
<213>  Homo sapiens

<400>  5468

Met Ala Gly Ser Arg Leu Pro Arg Gln Leu Phe Leu Gln Gly Val Ala 
1               5                   10                  15      


Ala Val Phe Met Phe Ala Phe Ala Ser Leu Tyr Thr Gln Ile Pro Gly 
            20                  25                  30          


Leu Tyr Gly Pro Glu Gly Ile Leu Pro Ala Arg Arg Thr Leu Arg Pro 
        35                  40                  45              


Gln Gly Lys Gly Arg Trp Gln Gln Leu Trp Glu Thr Pro Thr Leu Leu 
    50                  55                  60                  


Trp Glu Ala Pro Arg Leu Gly Leu Asp Thr Ala Gln Gly Leu Glu Leu 
65                  70                  75                  80  


Leu Ser Leu Leu Gly Ala Leu Val Ala Leu Gly Ala Leu Leu Leu Ser 
                85                  90                  95      


Pro Leu Arg His Pro Val Ile Tyr Leu Leu Leu Trp Ala Ala Tyr Leu 
            100                 105                 110         


Ser Ala Cys Gln Val Gly Gln Val Phe Leu Tyr Phe Gln Trp Asp Ser 
        115                 120                 125             


Leu Leu Leu Glu Thr Gly Phe Leu Ala Val Leu Val Ala Pro Leu Arg 
    130                 135                 140                 


Pro Ala Ser His Arg Lys Glu Ala Pro Gln Gly Arg Gln Ala Gly Ala 
145                 150                 155                 160 


Leu Pro His Glu Asp Leu Pro Phe Trp Leu Val Arg Trp Leu Leu Phe 
                165                 170                 175     


Arg Leu Met Phe Ala Ser Gly Val Val Lys Leu Thr Ser Arg Cys Pro 
            180                 185                 190         


Ala Trp Trp Gly Leu Thr Ala Leu Thr Tyr His Tyr Glu Thr Gln Cys 
        195                 200                 205             


Leu Pro Thr Pro Ala Ala Trp Phe Ala His His Leu Pro Val Trp Leu 
    210                 215                 220                 


His Lys Leu Ser Val Val Ala Thr Phe Leu Ile Glu Ile Ala Val Pro 
225                 230                 235                 240 


Pro Leu Phe Phe Ala Pro Ile Arg Arg Leu Arg Leu Ala Ala Phe Tyr 
                245                 250                 255     


Ser Gln Val Leu Leu Gln Val Leu Ile Ile Ile Thr Gly Asn Tyr Asn 
            260                 265                 270         


Phe Phe Asn Leu Met Thr Leu Val Leu Thr Thr Ala Leu Leu Asp Asp 
        275                 280                 285             


Gln His Leu Ala Ala Glu Pro Gly His Gly Ser Arg Lys Lys Thr Ala 
    290                 295                 300                 


Thr Ser Trp Pro Lys Ala Leu Leu Ala Thr Leu Ser Leu Leu Leu Glu 
305                 310                 315                 320 


Leu Ala Val Tyr Gly Leu Leu Ala Tyr Gly Thr Val His Tyr Phe Gly 
                325                 330                 335     


Leu Glu Val Asp Trp Gln Gln Arg Thr Ile His Ser Arg Thr Thr Phe 
            340                 345                 350         


Thr Phe His Gln Phe Ser Gln Trp Leu Lys Thr Leu Thr Leu Pro Thr 
        355                 360                 365             


Val Trp Leu Gly Val Ala Ser Leu Val Trp Glu Leu Leu Ser Ala Leu 
    370                 375                 380                 


Trp Arg Trp Thr Gln Val Arg Gly Trp Leu Arg Lys Leu Ser Ala Val 
385                 390                 395                 400 


Val Gln Leu Ser Leu Val Gly Thr Ala Thr Val Ala Leu Phe Leu Ile 
                405                 410                 415     


Ser Leu Val Pro Tyr Ser Tyr Val Glu Pro Gly Thr His Gly Arg Leu 
            420                 425                 430         


Trp Thr Gly Ala His Arg Leu Phe Gly Ala Val Glu His Leu Gln Leu 
        435                 440                 445             


Ala Asn Ser Tyr Gly Leu Phe Arg Arg Met Thr Gly Leu Gly Gly Arg 
    450                 455                 460                 


Pro Glu Val Val Leu Glu Gly Ser Tyr Asp Gly His His Trp Thr Glu 
465                 470                 475                 480 


Ile Glu Phe Met Tyr Lys Pro Gly Asn Leu Ser Arg Pro Pro Pro Val 
                485                 490                 495     


Val Val Pro His Gln Pro Arg Leu Asp Trp Gln Met Trp Phe Ala Ala 
            500                 505                 510         


Leu Gly Pro His Thr His Ser Pro Trp Phe Thr Ser Leu Val Leu Arg 
        515                 520                 525             


Leu Leu Gln Gly Lys Glu Pro Val Ile Arg Leu Val Gln Ser Gln Val 
    530                 535                 540                 


Ala Arg Tyr Pro Phe His Lys Gln Pro Pro Thr Tyr Val Arg Ala Gln 
545                 550                 555                 560 


Arg Tyr Lys Tyr Trp Phe Ser Gln Pro Gly Glu Gln Gly Gln Trp Trp 
                565                 570                 575     


Arg Arg Gln Trp Val Glu Glu Phe Phe Pro Ser Val Ser Leu Gly Asp 
            580                 585                 590         


Pro Thr Leu Glu Thr Leu Leu Arg Gln Phe Gly Leu Gln Glu Lys Ser 
        595                 600                 605             


Pro Pro Arg Thr Arg Ser Ala Asn Ser Thr Leu Ala Gln Ala Leu His 
    610                 615                 620                 


Trp Thr Arg Ser Gln Leu Ser Pro Leu Glu Ala Pro Ala Leu Leu Trp 
625                 630                 635                 640 


Gly Leu Leu Met Ala Val Gly Ala Val Arg Phe Val Gln Ala Leu Leu 
                645                 650                 655     


Ala Pro Cys Ser Leu Arg Ser Ser Pro Leu Ala Pro Val Ser Gly Glu 
            660                 665                 670         


Lys Arg Arg Pro Ala Ser Gln Lys Asp Ser Gly Ala Ala Ser Glu Gln 
        675                 680                 685             


Ala Thr Ala Ala Pro Asn Pro Cys Ser Ser Ser Ser Arg Thr Thr Arg 
    690                 695                 700                 


Arg Lys Lys 
705         


<210>  5469
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  5469

Met Ser Phe Ser Leu Asn Phe Thr Leu Pro Ala Asn Thr Thr Ser Ser 
1               5                   10                  15      


Pro Val Thr Gly Gly Lys Glu Thr Asp Cys Gly Pro Ser Leu Gly Leu 
            20                  25                  30          


Ala Ala Gly Ile Pro Leu Leu Val Ala Thr Ala Leu Leu Val Ala Leu 
        35                  40                  45              


Leu Phe Thr Leu Ile His Arg Arg Arg Ser Ser Ile Glu Ala Met Glu 
    50                  55                  60                  


Glu Ser Asp Arg Pro Cys Glu Ile Ser Glu Ile Asp Asp Asn Pro Lys 
65                  70                  75                  80  


Ile Ser Glu Asn Pro Arg Arg Ser Pro Thr His Glu Lys Asn Thr Met 
                85                  90                  95      


Gly Ala Gln Glu Ala His Ile Tyr Val Lys Thr Val Ala Gly Ser Glu 
            100                 105                 110         


Glu Pro Val His Asp Arg Tyr Arg Pro Thr Ile Glu Met Glu Arg Arg 
        115                 120                 125             


Arg Gly Leu Trp Trp Leu Val Pro Arg Leu Ser Leu Glu 
    130                 135                 140     


<210>  5470
<211>  799
<212>  PRT
<213>  Homo sapiens

<400>  5470

Met Ala Arg Thr Ala Pro Val Glu Pro Pro Leu Arg His Ser Ala Pro 
1               5                   10                  15      


Pro Ser Pro Ala Ala Gly Glu Pro Arg Thr Ser Val Glu Ala Ala Val 
            20                  25                  30          


Ala Pro Arg Arg Val Leu Phe Ala Asp Glu Ala Leu Gly Leu Pro Leu 
        35                  40                  45              


Ala Gln Leu Arg Arg Tyr Arg Pro Trp Gly Gly Pro Gly Ala Gly Lys 
    50                  55                  60                  


Met Ala Ala Ala Ala Gly Gln Asp Gly Gly Gly Gly Gly Gly Ala Asp 
65                  70                  75                  80  


Glu Asp Asp Asp Gly Glu Asp Gly Asp Glu Gly Glu Glu Glu Glu Glu 
                85                  90                  95      


Ala Cys Pro Glu Pro Ser Pro Leu Cys Pro Val Pro Ala Gly Gly Gly 
            100                 105                 110         


Phe Tyr Leu Val Pro Thr Phe Ser Leu Pro Pro Ala Pro Gly Arg Leu 
        115                 120                 125             


Glu Arg Leu Gly Arg Val Met Val Glu Leu Glu Ala Leu Leu Pro Pro 
    130                 135                 140                 


Pro Gly Ala Val Pro Gly Gly Ala Gly Val Trp Val Pro Gly Gly Arg 
145                 150                 155                 160 


Pro Pro Val Leu Arg Gly Leu Val Arg Val Leu Asn Arg Ser Phe Glu 
                165                 170                 175     


Lys Ala Val His Val Arg Ala Ser His Asp Gly Trp Ala Ser Phe Cys 
            180                 185                 190         


Asp His Pro Ala Arg Tyr Val Pro Arg Ser Pro Pro Trp Ala Gly Ala 
        195                 200                 205             


Gly Gly Thr Gly Ala Gly Asp Pro Ile Leu Asp Pro Gly Leu Gly Leu 
    210                 215                 220                 


Gly Pro Gly Gln Ala Ser Ala Ser Ser Pro Asp Asp Gly Gly Arg Thr 
225                 230                 235                 240 


Asp Arg Phe Ala Phe Gln Leu Pro Phe Ala Glu Gly Ala Gly Asp Gly 
                245                 250                 255     


Ala Arg Leu Asp Phe Val Val Arg Tyr Glu Thr Pro Glu Gly Thr Phe 
            260                 265                 270         


Trp Ala Asn Asn His Gly Arg Asn Tyr Thr Val Leu Leu Arg Ile Ala 
        275                 280                 285             


Pro Ala Pro Thr Pro Thr Asp Ala Glu Gly Leu Pro Gln Gln Gln Gln 
    290                 295                 300                 


Leu Pro Gln Leu Glu Pro Gln Pro Glu Cys Gln Gly Pro Val Glu Ala 
305                 310                 315                 320 


Glu Ala Arg Gln Leu Lys Ser Cys Met Lys Pro Val Arg Arg Arg Pro 
                325                 330                 335     


Ala Glu Glu Glu Leu Lys Thr Lys Asn Met Asp Asp Asn Thr Phe Ala 
            340                 345                 350         


Met Ala Glu His Pro Asp Val Gln Glu Ser Val Gly Pro Leu Val Ala 
        355                 360                 365             


Pro Thr Pro Leu Arg Pro Trp Pro Gln Met Thr Leu Gln Val Ser Asp 
    370                 375                 380                 


Val Pro Met Thr Gly Asn Pro Ala Glu Glu Gly Asp Val Pro Arg Ser 
385                 390                 395                 400 


Ser Pro Pro Val Ala Phe Thr Glu Val Leu Gln Ala Pro Ala Ile Arg 
                405                 410                 415     


Ile Pro Pro Ser Ser Pro Leu Cys Gly Leu Gly Gly Ser Pro Arg Asp 
            420                 425                 430         


Gln Ala Ser Gly Pro Asp Ala Ser Glu Gly Ala Thr Gly Pro Phe Leu 
        435                 440                 445             


Glu Pro Ser Gln Gln Gln Ala Glu Ala Thr Trp Gly Val Ser Ser Glu 
    450                 455                 460                 


Asn Gly Gly Gly Leu Glu Ala Val Ser Gly Ser Glu Glu Leu Leu Gly 
465                 470                 475                 480 


Glu Asp Thr Ile Asp Gln Glu Leu Glu Gln Leu Tyr Leu Ser His Leu 
                485                 490                 495     


Ser Arg Leu Arg Ala Ala Val Ala Ala Gly Gly Ala Gly Gly Gly Gly 
            500                 505                 510         


Glu Gly Ser Thr Asp Gly Gly Met Ser Pro Ser His Pro Leu Gly Ile 
        515                 520                 525             


Leu Thr Asp Arg Asp Leu Ile Leu Lys Trp Pro Gly Pro Glu Arg Ala 
    530                 535                 540                 


Leu Asn Ser Ala Leu Ala Glu Glu Ile Thr Leu His Tyr Ala Arg Leu 
545                 550                 555                 560 


Gly Arg Gly Val Glu Leu Ile Lys Asp Thr Glu Asp Pro Asp Asp Glu 
                565                 570                 575     


Gly Glu Gly Glu Glu Gly Leu Ser Val Thr Pro Ser Ser Pro Glu Gly 
            580                 585                 590         


Asp Ser Pro Lys Glu Ser Pro Pro Glu Ile Leu Ser Gly Ala Arg Ser 
        595                 600                 605             


Val Val Ala Thr Met Gly Asp Val Trp Leu Pro Trp Ala Glu Gly Ser 
    610                 615                 620                 


Gly Cys Asp Gly Pro Val Val Leu Gly Thr Glu Gly Gln Phe Ile Gly 
625                 630                 635                 640 


Asp Pro Glu Lys Gly Met Gly Lys Asp Thr Ser Ser Leu His Met Asn 
                645                 650                 655     


Arg Val Ile Ala Gly Val Thr Glu Ser Leu Gly Glu Ala Gly Thr Glu 
            660                 665                 670         


Ala Gln Ile Glu Val Thr Ser Glu Trp Ala Gly Ser Leu Asp Pro Ile 
        675                 680                 685             


Ser Gly Lys Glu Pro Ala Ser Pro Val Leu Leu Gln Gly Gln Asn Pro 
    690                 695                 700                 


Thr Leu Leu Ser Pro Leu Gly Ala Glu Val Cys Leu Ser Ser Val Ala 
705                 710                 715                 720 


Arg Pro His Val Ser Ser Gln Asp Glu Lys Asp Ala Gly Pro Ser Leu 
                725                 730                 735     


Glu Pro Pro Lys Lys Ser Pro Thr Leu Ala Val Pro Ala Glu Cys Val 
            740                 745                 750         


Cys Ala Leu Pro Pro Gln Leu Arg Gly Pro Leu Thr Gln Thr Leu Gly 
        755                 760                 765             


Val Leu Ala Gly Leu Val Val Val Pro Val Ala Leu Asn Ser Gly Val 
    770                 775                 780                 


Ser Leu Leu Val Leu Ala Leu Cys Leu Ser Leu Ala Trp Phe Ser 
785                 790                 795                 


<210>  5471
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  5471

Met Ala Pro Lys Leu Leu Leu Leu Leu Cys Leu Phe Ser Gly Leu His 
1               5                   10                  15      


Ala Arg Ser Arg Lys Val Glu Glu Asp Glu Tyr Glu Asp Ser Ser Ser 
            20                  25                  30          


Asn Gln Lys Trp Val Leu Ala Pro Lys Ser Gln Asp Thr Asp Val Thr 
        35                  40                  45              


Leu Ile Leu Asn Lys Leu Leu Arg Glu Tyr Asp Lys Lys Leu Arg Pro 
    50                  55                  60                  


Asp Ile Gly Ile Lys Pro Thr Val Ile Asp Val Asp Ile Tyr Val Asn 
65                  70                  75                  80  


Ser Ile Gly Pro Val Ser Ser Ile Asn Met Glu Tyr Gln Ile Asp Ile 
                85                  90                  95      


Phe Phe Ala Gln Thr Trp Thr Asp Ser Arg Leu Arg Phe Asn Ser Thr 
            100                 105                 110         


Met Lys Ile Leu Thr Leu Asn Ser Asn Met Val Gly Leu Ile Trp Ile 
        115                 120                 125             


Pro Asp Thr Ile Phe Arg Asn Ser Lys Thr Ala Glu Ala His Trp Ile 
    130                 135                 140                 


Thr Thr Pro Asn Gln Leu Leu Arg Ile Trp Asn Asp Gly Lys Ile Leu 
145                 150                 155                 160 


Tyr Thr Leu Arg Leu Thr Ile Asn Ala Glu Cys Gln Leu Gln Leu His 
                165                 170                 175     


Asn Phe Pro Met Asp Glu His Ser Cys Pro Leu Ile Phe Ser Ser Tyr 
            180                 185                 190         


Gly Tyr Pro Lys Glu Glu Met Ile Tyr Arg Trp Arg Lys Asn Ser Val 
        195                 200                 205             


Glu Ala Ala Asp Gln Lys Ser Trp Arg Leu Tyr Gln Phe Asp Phe Met 
    210                 215                 220                 


Gly Leu Arg Asn Thr Thr Glu Ile Val Thr Thr Ser Ala Gly Asp Tyr 
225                 230                 235                 240 


Val Val Met Thr Ile Tyr Phe Glu Leu Ser Arg Arg Met Gly Tyr Phe 
                245                 250                 255     


Thr Ile Gln Thr Tyr Ile Pro Cys Ile Leu Thr Val Val Leu Ser Trp 
            260                 265                 270         


Val Ser Phe Trp Ile Lys Lys Asp Ala Thr Pro Ala Arg Thr Ala Leu 
        275                 280                 285             


Gly Ile Thr Thr Val Leu Thr Met Thr Thr Leu Ser Thr Ile Ala Arg 
    290                 295                 300                 


Lys Ser Leu Pro Arg Val Ser Tyr Val Thr Ala Met Asp Leu Phe Val 
305                 310                 315                 320 


Thr Val Cys Phe Leu Phe Val Phe Ala Ala Leu Met Glu Tyr Ala Thr 
                325                 330                 335     


Leu Asn Tyr Tyr Ser Ser Cys Arg Lys Pro Thr Thr Thr Lys Lys Thr 
            340                 345                 350         


Thr Ser Leu Leu His Pro Asp Ser Ser Arg Trp Ile Pro Glu Arg Ile 
        355                 360                 365             


Ser Leu Gln Ala Pro Ser Asn Tyr Ser Leu Leu Asp Met Arg Pro Pro 
    370                 375                 380                 


Pro Thr Ala Met Ile Thr Leu Asn Asn Ser Val Tyr Trp Gln Glu Phe 
385                 390                 395                 400 


Glu Asp Thr Cys Val Tyr Glu Cys Leu Asp Gly Lys Asp Cys Gln Ser 
                405                 410                 415     


Phe Phe Cys Cys Tyr Glu Glu Cys Lys Ser Gly Ser Trp Arg Lys Gly 
            420                 425                 430         


Arg Ile His Ile Asp Ile Leu Glu Leu Asp Ser Tyr Ser Arg Val Phe 
        435                 440                 445             


Phe Pro Thr Ser Phe Leu Leu Phe Asn Leu Val Tyr Trp Val Gly Tyr 
    450                 455                 460                 


Leu Tyr Leu 
465         


<210>  5472
<211>  3564
<212>  PRT
<213>  Homo sapiens

<400>  5472

Met Thr Ala Trp Arg Arg Phe Gln Ser Leu Leu Leu Leu Leu Gly Leu 
1               5                   10                  15      


Leu Val Leu Cys Ala Arg Leu Leu Thr Ala Ala Lys Gly Gln Asn Cys 
            20                  25                  30          


Gly Gly Leu Val Gln Gly Pro Asn Gly Thr Ile Glu Ser Pro Gly Phe 
        35                  40                  45              


Pro His Gly Tyr Pro Asn Tyr Ala Asn Cys Thr Trp Ile Ile Ile Thr 
    50                  55                  60                  


Gly Glu Arg Asn Arg Ile Gln Leu Ser Phe His Thr Phe Ala Leu Glu 
65                  70                  75                  80  


Glu Asp Phe Asp Ile Leu Ser Val Tyr Asp Gly Gln Pro Gln Gln Gly 
                85                  90                  95      


Asn Leu Lys Val Arg Leu Ser Gly Phe Gln Leu Pro Ser Ser Ile Val 
            100                 105                 110         


Ser Thr Gly Ser Ile Leu Thr Leu Trp Phe Thr Thr Asp Phe Ala Val 
        115                 120                 125             


Ser Ala Gln Gly Phe Lys Ala Leu Tyr Glu Val Leu Pro Ser His Thr 
    130                 135                 140                 


Cys Gly Asn Pro Gly Glu Ile Leu Lys Gly Val Leu His Gly Thr Arg 
145                 150                 155                 160 


Phe Asn Ile Gly Asp Lys Ile Arg Tyr Ser Cys Leu Pro Gly Tyr Ile 
                165                 170                 175     


Leu Glu Gly His Ala Ile Leu Thr Cys Ile Val Ser Pro Gly Asn Gly 
            180                 185                 190         


Ala Ser Trp Asp Phe Pro Ala Pro Phe Cys Arg Ala Glu Gly Ala Cys 
        195                 200                 205             


Gly Gly Thr Leu Arg Gly Thr Ser Ser Ser Ile Ser Ser Pro His Phe 
    210                 215                 220                 


Pro Ser Glu Tyr Glu Asn Asn Ala Asp Cys Thr Trp Thr Ile Leu Ala 
225                 230                 235                 240 


Glu Pro Gly Asp Thr Ile Ala Leu Val Phe Thr Asp Phe Gln Leu Glu 
                245                 250                 255     


Glu Gly Tyr Asp Phe Leu Glu Ile Ser Gly Thr Glu Ala Pro Ser Ile 
            260                 265                 270         


Trp Leu Thr Gly Met Asn Leu Pro Ser Pro Val Ile Ser Ser Lys Asn 
        275                 280                 285             


Trp Leu Arg Leu His Phe Thr Ser Asp Ser Asn His Arg Arg Lys Gly 
    290                 295                 300                 


Phe Asn Ala Gln Phe Gln Val Lys Lys Ala Ile Glu Leu Lys Ser Arg 
305                 310                 315                 320 


Gly Val Lys Met Leu Pro Ser Lys Asp Gly Ser His Lys Asn Ser Val 
                325                 330                 335     


Leu Ser Gln Gly Gly Val Ala Leu Val Ser Asp Met Cys Pro Asp Pro 
            340                 345                 350         


Gly Ile Pro Glu Asn Gly Arg Arg Ala Gly Ser Asp Phe Arg Val Gly 
        355                 360                 365             


Ala Asn Val Gln Phe Ser Cys Glu Asp Asn Tyr Val Leu Gln Gly Ser 
    370                 375                 380                 


Lys Ser Ile Thr Cys Gln Arg Val Thr Glu Thr Leu Ala Ala Trp Ser 
385                 390                 395                 400 


Asp His Arg Pro Ile Cys Arg Ala Arg Thr Cys Gly Ser Asn Leu Arg 
                405                 410                 415     


Gly Pro Ser Gly Val Ile Thr Ser Pro Asn Tyr Pro Val Gln Tyr Glu 
            420                 425                 430         


Asp Asn Ala His Cys Val Trp Val Ile Thr Thr Thr Asp Pro Asp Lys 
        435                 440                 445             


Val Ile Lys Leu Ala Phe Glu Glu Phe Glu Leu Glu Arg Gly Tyr Asp 
    450                 455                 460                 


Thr Leu Thr Val Gly Asp Ala Gly Lys Val Gly Asp Thr Arg Ser Val 
465                 470                 475                 480 


Leu Tyr Val Leu Thr Gly Ser Ser Val Pro Asp Leu Ile Val Ser Met 
                485                 490                 495     


Ser Asn Gln Met Trp Leu His Leu Gln Ser Asp Asp Ser Ile Gly Ser 
            500                 505                 510         


Pro Gly Phe Lys Ala Val Tyr Gln Glu Ile Glu Lys Gly Gly Cys Gly 
        515                 520                 525             


Asp Pro Gly Ile Pro Ala Tyr Gly Lys Arg Thr Gly Ser Ser Phe Leu 
    530                 535                 540                 


His Gly Asp Thr Leu Thr Phe Glu Cys Pro Ala Ala Phe Glu Leu Val 
545                 550                 555                 560 


Gly Glu Arg Val Ile Thr Cys Gln Gln Asn Asn Gln Trp Ser Gly Asn 
                565                 570                 575     


Lys Pro Ser Cys Val Phe Ser Cys Phe Phe Asn Phe Thr Ala Ser Ser 
            580                 585                 590         


Gly Ile Ile Leu Ser Pro Asn Tyr Pro Glu Glu Tyr Gly Asn Asn Met 
        595                 600                 605             


Asn Cys Val Trp Leu Ile Ile Ser Glu Pro Gly Ser Arg Ile His Leu 
    610                 615                 620                 


Ile Phe Asn Asp Phe Asp Val Glu Pro Gln Phe Asp Phe Leu Ala Val 
625                 630                 635                 640 


Lys Asp Asp Gly Ile Ser Asp Ile Thr Val Leu Gly Thr Phe Ser Gly 
                645                 650                 655     


Asn Glu Val Pro Ser Gln Leu Ala Ser Ser Gly His Ile Val Arg Leu 
            660                 665                 670         


Glu Phe Gln Ser Asp His Ser Thr Thr Gly Arg Gly Phe Asn Ile Thr 
        675                 680                 685             


Tyr Thr Thr Phe Gly Gln Asn Glu Cys His Asp Pro Gly Ile Pro Ile 
    690                 695                 700                 


Asn Gly Arg Arg Phe Gly Asp Arg Phe Leu Leu Gly Ser Ser Val Ser 
705                 710                 715                 720 


Phe His Cys Asp Asp Gly Phe Val Lys Thr Gln Gly Ser Glu Ser Ile 
                725                 730                 735     


Thr Cys Ile Leu Gln Asp Gly Asn Val Val Trp Ser Ser Thr Val Pro 
            740                 745                 750         


Arg Cys Glu Ala Pro Cys Gly Gly His Leu Thr Ala Ser Ser Gly Val 
        755                 760                 765             


Ile Leu Pro Pro Gly Trp Pro Gly Tyr Tyr Lys Asp Ser Leu His Cys 
    770                 775                 780                 


Glu Trp Ile Ile Glu Ala Lys Pro Gly His Ser Ile Lys Ile Thr Phe 
785                 790                 795                 800 


Asp Arg Phe Gln Thr Glu Val Asn Tyr Asp Thr Leu Glu Val Arg Asp 
                805                 810                 815     


Gly Pro Ala Ser Ser Ser Pro Leu Ile Gly Glu Tyr His Gly Thr Gln 
            820                 825                 830         


Ala Pro Gln Phe Leu Ile Ser Thr Gly Asn Phe Met Tyr Leu Leu Phe 
        835                 840                 845             


Thr Thr Asp Asn Ser Arg Ser Ser Ile Gly Phe Leu Ile His Tyr Glu 
    850                 855                 860                 


Ser Val Thr Leu Glu Ser Asp Ser Cys Leu Asp Pro Gly Ile Pro Val 
865                 870                 875                 880 


Asn Gly His Arg His Gly Gly Asp Phe Gly Ile Arg Ser Thr Val Thr 
                885                 890                 895     


Phe Ser Cys Asp Pro Gly Tyr Thr Leu Ser Asp Asp Glu Pro Leu Val 
            900                 905                 910         


Cys Glu Arg Asn His Gln Trp Asn His Ala Leu Pro Ser Cys Asp Ala 
        915                 920                 925             


Leu Cys Gly Gly Tyr Ile Gln Gly Lys Ser Gly Thr Val Leu Ser Pro 
    930                 935                 940                 


Gly Phe Pro Asp Phe Tyr Pro Asn Ser Leu Asn Cys Thr Trp Thr Ile 
945                 950                 955                 960 


Glu Val Ser His Gly Lys Gly Val Gln Met Ile Phe His Thr Phe His 
                965                 970                 975     


Leu Glu Ser Ser His Asp Tyr Leu Leu Ile Thr Glu Asp Gly Ser Phe 
            980                 985                 990         


Ser Glu Pro Val Ala Arg Leu Thr  Gly Ser Val Leu Pro  His Thr Ile 
        995                 1000                 1005             


Lys Ala  Gly Leu Phe Gly Asn  Phe Thr Ala Gln Leu  Arg Phe Ile 
    1010                 1015                 1020             


Ser Asp  Phe Ser Ile Ser Tyr  Glu Gly Phe Asn Ile  Thr Phe Ser 
    1025                 1030                 1035             


Glu Tyr  Asp Leu Glu Pro Cys  Asp Asp Pro Gly Val  Pro Ala Phe 
    1040                 1045                 1050             


Ser Arg  Arg Ile Gly Phe His  Phe Gly Val Gly Asp  Ser Leu Thr 
    1055                 1060                 1065             


Phe Ser  Cys Phe Leu Gly Tyr  Arg Leu Glu Gly Ala  Thr Lys Leu 
    1070                 1075                 1080             


Thr Cys  Leu Gly Gly Gly Arg  Arg Val Trp Ser Ala  Pro Leu Pro 
    1085                 1090                 1095             


Arg Cys  Val Ala Glu Cys Gly  Ala Ser Val Lys Gly  Asn Glu Gly 
    1100                 1105                 1110             


Thr Leu  Leu Ser Pro Asn Phe  Pro Ser Asn Tyr Asp  Asn Asn His 
    1115                 1120                 1125             


Glu Cys  Ile Tyr Lys Ile Glu  Thr Glu Ala Gly Lys  Gly Ile His 
    1130                 1135                 1140             


Leu Arg  Thr Arg Ser Phe Gln  Leu Phe Glu Gly Asp  Thr Leu Lys 
    1145                 1150                 1155             


Val Tyr  Asp Gly Lys Asp Ser  Ser Ser Arg Pro Leu  Gly Thr Phe 
    1160                 1165                 1170             


Thr Lys  Asn Glu Leu Leu Gly  Leu Ile Leu Asn Ser  Thr Ser Asn 
    1175                 1180                 1185             


His Leu  Trp Leu Glu Phe Asn  Thr Asn Gly Ser Asp  Thr Asp Gln 
    1190                 1195                 1200             


Gly Phe  Gln Leu Thr Tyr Thr  Ser Phe Asp Leu Val  Lys Cys Glu 
    1205                 1210                 1215             


Asp Pro  Gly Ile Pro Asn Tyr  Gly Tyr Arg Ile Arg  Asp Glu Gly 
    1220                 1225                 1230             


His Phe  Thr Asp Thr Val Val  Leu Tyr Ser Cys Asn  Pro Gly Tyr 
    1235                 1240                 1245             


Ala Met  His Gly Ser Asn Thr  Leu Thr Cys Leu Ser  Gly Asp Arg 
    1250                 1255                 1260             


Arg Val  Trp Asp Lys Pro Leu  Pro Ser Cys Ile Ala  Glu Cys Gly 
    1265                 1270                 1275             


Gly Gln  Ile His Ala Ala Thr  Ser Gly Arg Ile Leu  Ser Pro Gly 
    1280                 1285                 1290             


Tyr Pro  Ala Pro Tyr Asp Asn  Asn Leu His Cys Thr  Trp Ile Ile 
    1295                 1300                 1305             


Glu Ala  Asp Pro Gly Lys Thr  Ile Ser Leu His Phe  Ile Val Phe 
    1310                 1315                 1320             


Asp Thr  Glu Met Ala His Asp  Ile Leu Lys Val Trp  Asp Gly Pro 
    1325                 1330                 1335             


Val Asp  Ser Asp Ile Leu Leu  Lys Glu Trp Ser Gly  Ser Ala Leu 
    1340                 1345                 1350             


Pro Glu  Asp Ile His Ser Thr  Phe Asn Ser Leu Thr  Leu Gln Phe 
    1355                 1360                 1365             


Asp Ser  Asp Phe Phe Ile Ser  Lys Ser Gly Phe Ser  Ile Gln Phe 
    1370                 1375                 1380             


Ser Thr  Ser Ile Ala Ala Thr  Cys Asn Asp Pro Gly  Met Pro Gln 
    1385                 1390                 1395             


Asn Gly  Thr Arg Tyr Gly Asp  Ser Arg Glu Ala Gly  Asp Thr Val 
    1400                 1405                 1410             


Thr Phe  Gln Cys Asp Pro Gly  Tyr Gln Leu Gln Gly  Gln Ala Lys 
    1415                 1420                 1425             


Ile Thr  Cys Val Gln Leu Asn  Asn Arg Phe Phe Trp  Gln Pro Asp 
    1430                 1435                 1440             


Pro Pro  Thr Cys Ile Ala Ala  Cys Gly Gly Asn Leu  Thr Gly Pro 
    1445                 1450                 1455             


Ala Gly  Val Ile Leu Ser Pro  Asn Tyr Pro Gln Pro  Tyr Pro Pro 
    1460                 1465                 1470             


Gly Lys  Glu Cys Asp Trp Arg  Val Lys Val Asn Pro  Asp Phe Val 
    1475                 1480                 1485             


Ile Ala  Leu Ile Phe Lys Ser  Phe Asn Met Glu Pro  Ser Tyr Asp 
    1490                 1495                 1500             


Phe Leu  His Ile Tyr Glu Gly  Glu Asp Ser Asn Ser  Pro Leu Ile 
    1505                 1510                 1515             


Gly Ser  Tyr Gln Gly Ser Gln  Ala Pro Glu Arg Ile  Glu Ser Ser 
    1520                 1525                 1530             


Gly Asn  Ser Leu Phe Leu Ala  Phe Arg Ser Asp Ala  Ser Val Gly 
    1535                 1540                 1545             


Leu Ser  Gly Phe Ala Ile Glu  Phe Lys Glu Lys Pro  Arg Glu Ala 
    1550                 1555                 1560             


Cys Phe  Asp Pro Gly Asn Ile  Met Asn Gly Thr Arg  Val Gly Thr 
    1565                 1570                 1575             


Asp Phe  Lys Leu Gly Ser Thr  Ile Thr Tyr Gln Cys  Asp Ser Gly 
    1580                 1585                 1590             


Tyr Lys  Ile Leu Asp Pro Ser  Ser Ile Thr Cys Val  Ile Gly Ala 
    1595                 1600                 1605             


Asp Gly  Lys Pro Ser Trp Asp  Gln Val Leu Pro Ser  Cys Asn Ala 
    1610                 1615                 1620             


Pro Cys  Gly Gly Gln Tyr Thr  Gly Ser Glu Gly Val  Val Leu Ser 
    1625                 1630                 1635             


Pro Asn  Tyr Pro His Asn Tyr  Thr Ala Gly Gln Ile  Cys Leu Tyr 
    1640                 1645                 1650             


Ser Ile  Thr Val Pro Lys Glu  Phe Val Val Phe Gly  Gln Phe Ala 
    1655                 1660                 1665             


Tyr Phe  Gln Thr Ala Leu Asn  Asp Leu Ala Glu Leu  Phe Asp Gly 
    1670                 1675                 1680             


Thr His  Ala Gln Ala Arg Leu  Leu Ser Ser Leu Ser  Gly Ser His 
    1685                 1690                 1695             


Ser Gly  Glu Thr Leu Pro Leu  Ala Thr Ser Asn Gln  Ile Leu Leu 
    1700                 1705                 1710             


Arg Phe  Ser Ala Lys Ser Gly  Ala Ser Ala Arg Gly  Phe His Phe 
    1715                 1720                 1725             


Val Tyr  Gln Ala Val Pro Arg  Thr Ser Asp Thr Gln  Cys Ser Ser 
    1730                 1735                 1740             


Val Pro  Glu Pro Arg Tyr Gly  Arg Arg Ile Gly Ser  Glu Phe Ser 
    1745                 1750                 1755             


Ala Gly  Ser Ile Val Arg Phe  Glu Cys Asn Pro Gly  Tyr Leu Leu 
    1760                 1765                 1770             


Gln Gly  Ser Thr Ala Leu His  Cys Gln Ser Val Pro  Asn Ala Leu 
    1775                 1780                 1785             


Ala Gln  Trp Asn Asp Thr Ile  Pro Ser Cys Val Val  Pro Cys Ser 
    1790                 1795                 1800             


Gly Asn  Phe Thr Gln Arg Arg  Gly Thr Ile Leu Ser  Pro Gly Tyr 
    1805                 1810                 1815             


Pro Glu  Pro Tyr Gly Asn Asn  Leu Asn Cys Ile Trp  Lys Ile Ile 
    1820                 1825                 1830             


Val Thr  Glu Gly Ser Gly Ile  Gln Ile Gln Val Ile  Ser Phe Ala 
    1835                 1840                 1845             


Thr Glu  Gln Asn Trp Asp Ser  Leu Glu Ile His Asp  Gly Gly Asp 
    1850                 1855                 1860             


Val Thr  Ala Pro Arg Leu Gly  Ser Phe Ser Gly Thr  Thr Val Pro 
    1865                 1870                 1875             


Ala Leu  Leu Asn Ser Thr Ser  Asn Gln Leu Tyr Leu  His Phe Gln 
    1880                 1885                 1890             


Ser Asp  Ile Ser Val Ala Ala  Ala Gly Phe His Leu  Glu Tyr Lys 
    1895                 1900                 1905             


Thr Val  Gly Leu Ala Ala Cys  Gln Glu Pro Ala Leu  Pro Ser Asn 
    1910                 1915                 1920             


Ser Ile  Lys Ile Gly Asp Arg  Tyr Met Val Asn Asp  Val Leu Ser 
    1925                 1930                 1935             


Phe Gln  Cys Glu Pro Gly Tyr  Thr Leu Gln Gly Arg  Ser His Ile 
    1940                 1945                 1950             


Ser Cys  Met Pro Gly Thr Val  Arg Arg Trp Asn Tyr  Pro Ser Pro 
    1955                 1960                 1965             


Leu Cys  Ile Ala Thr Cys Gly  Gly Thr Leu Ser Thr  Leu Gly Gly 
    1970                 1975                 1980             


Val Ile  Leu Ser Pro Gly Phe  Pro Gly Ser Tyr Pro  Asn Asn Leu 
    1985                 1990                 1995             


Asp Cys  Thr Trp Arg Ile Ser  Leu Pro Ile Gly Tyr  Gly Ala His 
    2000                 2005                 2010             


Ile Gln  Phe Leu Asn Phe Ser  Thr Glu Ala Asn His  Asp Phe Leu 
    2015                 2020                 2025             


Glu Ile  Gln Asn Gly Pro Tyr  His Thr Ser Pro Met  Ile Gly Gln 
    2030                 2035                 2040             


Phe Ser  Gly Thr Asp Leu Pro  Ala Ala Leu Leu Ser  Thr Thr His 
    2045                 2050                 2055             


Glu Thr  Leu Ile His Phe Tyr  Ser Asp His Ser Gln  Asn Arg Gln 
    2060                 2065                 2070             


Gly Phe  Lys Leu Ala Tyr Gln  Ala Tyr Glu Leu Gln  Asn Cys Pro 
    2075                 2080                 2085             


Asp Pro  Pro Pro Phe Gln Asn  Gly Tyr Met Ile Asn  Ser Asp Tyr 
    2090                 2095                 2100             


Ser Val  Gly Gln Ser Val Ser  Phe Glu Cys Tyr Pro  Gly Tyr Ile 
    2105                 2110                 2115             


Leu Ile  Gly His Pro Val Leu  Thr Cys Gln His Gly  Ile Asn Arg 
    2120                 2125                 2130             


Asn Trp  Asn Tyr Pro Phe Pro  Arg Cys Asp Ala Pro  Cys Gly Tyr 
    2135                 2140                 2145             


Asn Val  Thr Ser Gln Asn Gly  Thr Ile Tyr Ser Pro  Gly Phe Pro 
    2150                 2155                 2160             


Asp Glu  Tyr Pro Ile Leu Lys  Asp Cys Ile Trp Leu  Ile Thr Val 
    2165                 2170                 2175             


Pro Pro  Gly His Gly Val Tyr  Ile Asn Phe Thr Leu  Leu Gln Thr 
    2180                 2185                 2190             


Glu Ala  Val Asn Asp Tyr Ile  Ala Val Trp Asp Gly  Pro Asp Gln 
    2195                 2200                 2205             


Asn Ser  Pro Gln Leu Gly Val  Phe Ser Gly Asn Thr  Ala Leu Glu 
    2210                 2215                 2220             


Thr Ala  Tyr Ser Ser Thr Asn  Gln Val Leu Leu Lys  Phe His Ser 
    2225                 2230                 2235             


Asp Phe  Ser Asn Gly Gly Phe  Phe Val Leu Asn Phe  His Ala Phe 
    2240                 2245                 2250             


Gln Leu  Lys Lys Cys Gln Pro  Pro Pro Ala Val Pro  Gln Ala Glu 
    2255                 2260                 2265             


Met Leu  Thr Glu Asp Asp Asp  Phe Glu Ile Gly Asp  Phe Val Lys 
    2270                 2275                 2280             


Tyr Gln  Cys His Pro Gly Tyr  Thr Leu Val Gly Thr  Asp Ile Leu 
    2285                 2290                 2295             


Thr Cys  Lys Leu Ser Ser Gln  Leu Gln Phe Glu Gly  Ser Leu Pro 
    2300                 2305                 2310             


Thr Cys  Glu Ala Gln Cys Pro  Ala Asn Glu Val Arg  Thr Gly Ser 
    2315                 2320                 2325             


Ser Gly  Val Ile Leu Ser Pro  Gly Tyr Pro Gly Asn  Tyr Phe Asn 
    2330                 2335                 2340             


Ser Gln  Thr Cys Ser Trp Ser  Ile Lys Val Glu Pro  Asn Tyr Asn 
    2345                 2350                 2355             


Ile Thr  Ile Phe Val Asp Thr  Phe Gln Ser Glu Lys  Gln Phe Asp 
    2360                 2365                 2370             


Ala Leu  Glu Val Phe Asp Gly  Ser Ser Gly Gln Ser  Pro Leu Leu 
    2375                 2380                 2385             


Val Val  Leu Ser Gly Asn His  Thr Glu Gln Ser Asn  Phe Thr Ser 
    2390                 2395                 2400             


Arg Ser  Asn Gln Leu Tyr Leu  Arg Trp Ser Thr Asp  His Ala Thr 
    2405                 2410                 2415             


Ser Lys  Lys Gly Phe Lys Ile  Arg Tyr Ala Ala Pro  Tyr Cys Ser 
    2420                 2425                 2430             


Leu Thr  His Pro Leu Lys Asn  Gly Gly Ile Leu Asn  Arg Thr Ala 
    2435                 2440                 2445             


Gly Ala  Val Gly Ser Lys Val  His Tyr Phe Cys Lys  Pro Gly Tyr 
    2450                 2455                 2460             


Arg Met  Val Gly His Ser Asn  Ala Thr Cys Arg Arg  Asn Pro Leu 
    2465                 2470                 2475             


Gly Met  Tyr Gln Trp Asp Ser  Leu Thr Pro Leu Cys  Gln Ala Val 
    2480                 2485                 2490             


Ser Cys  Gly Ile Pro Glu Ser  Pro Gly Asn Gly Ser  Phe Thr Gly 
    2495                 2500                 2505             


Asn Glu  Phe Thr Leu Asp Ser  Lys Val Val Tyr Glu  Cys His Glu 
    2510                 2515                 2520             


Gly Phe  Lys Leu Glu Ser Ser  Gln Gln Ala Thr Ala  Val Cys Gln 
    2525                 2530                 2535             


Glu Asp  Gly Leu Trp Ser Asn  Lys Gly Lys Pro Pro  Thr Cys Lys 
    2540                 2545                 2550             


Pro Val  Ala Cys Pro Ser Ile  Glu Ala Gln Leu Ser  Glu His Val 
    2555                 2560                 2565             


Ile Trp  Arg Leu Val Ser Gly  Ser Leu Asn Glu Tyr  Gly Ala Gln 
    2570                 2575                 2580             


Val Leu  Leu Ser Cys Ser Pro  Gly Tyr Tyr Leu Glu  Gly Trp Arg 
    2585                 2590                 2595             


Leu Leu  Arg Cys Gln Ala Asn  Gly Thr Trp Asn Ile  Gly Asp Glu 
    2600                 2605                 2610             


Arg Pro  Ser Cys Arg Val Ile  Ser Cys Gly Ser Leu  Ser Phe Pro 
    2615                 2620                 2625             


Pro Asn  Gly Asn Lys Ile Gly  Thr Leu Thr Val Tyr  Gly Ala Thr 
    2630                 2635                 2640             


Ala Ile  Phe Thr Cys Asn Thr  Gly Tyr Thr Leu Val  Gly Ser His 
    2645                 2650                 2655             


Val Arg  Glu Cys Leu Ala Asn  Gly Leu Trp Ser Gly  Ser Glu Thr 
    2660                 2665                 2670             


Arg Cys  Leu Ala Gly His Cys  Gly Ser Pro Asp Pro  Ile Val Asn 
    2675                 2680                 2685             


Gly His  Ile Ser Gly Asp Gly  Phe Ser Tyr Arg Asp  Thr Val Val 
    2690                 2695                 2700             


Tyr Gln  Cys Asn Pro Gly Phe  Arg Leu Val Gly Thr  Ser Val Arg 
    2705                 2710                 2715             


Ile Cys  Leu Gln Asp His Lys  Trp Ser Gly Gln Thr  Pro Val Cys 
    2720                 2725                 2730             


Val Pro  Ile Thr Cys Gly His  Pro Gly Asn Pro Ala  His Gly Phe 
    2735                 2740                 2745             


Thr Asn  Gly Ser Glu Phe Asn  Leu Asn Asp Val Val  Asn Phe Thr 
    2750                 2755                 2760             


Cys Asn  Thr Gly Tyr Leu Leu  Gln Gly Val Ser Arg  Ala Gln Cys 
    2765                 2770                 2775             


Arg Ser  Asn Gly Gln Trp Ser  Ser Pro Leu Pro Thr  Cys Arg Val 
    2780                 2785                 2790             


Val Asn  Cys Ser Asp Pro Gly  Phe Val Glu Asn Ala  Ile Arg His 
    2795                 2800                 2805             


Gly Gln  Gln Asn Phe Pro Glu  Ser Phe Glu Tyr Gly  Met Ser Ile 
    2810                 2815                 2820             


Leu Tyr  His Cys Lys Lys Gly  Phe Tyr Leu Leu Gly  Ser Ser Ala 
    2825                 2830                 2835             


Leu Thr  Cys Met Ala Asn Gly  Leu Trp Asp Arg Ser  Leu Pro Lys 
    2840                 2845                 2850             


Cys Leu  Ala Ile Ser Cys Gly  His Pro Gly Val Pro  Ala Asn Ala 
    2855                 2860                 2865             


Val Leu  Thr Gly Glu Leu Phe  Thr Tyr Gly Ala Val  Val His Tyr 
    2870                 2875                 2880             


Ser Cys  Arg Gly Ser Glu Ser  Leu Ile Gly Asn Asp  Thr Arg Val 
    2885                 2890                 2895             


Cys Gln  Glu Asp Ser His Trp  Ser Gly Ala Leu Pro  His Cys Thr 
    2900                 2905                 2910             


Gly Asn  Asn Pro Gly Phe Cys  Gly Asp Pro Gly Thr  Pro Ala His 
    2915                 2920                 2925             


Gly Ser  Arg Leu Gly Asp Asp  Phe Lys Thr Lys Ser  Leu Leu Arg 
    2930                 2935                 2940             


Phe Ser  Cys Glu Met Gly His  Gln Leu Arg Gly Ser  Pro Glu Arg 
    2945                 2950                 2955             


Thr Cys  Leu Leu Asn Gly Ser  Trp Ser Gly Leu Gln  Pro Val Cys 
    2960                 2965                 2970             


Glu Ala  Val Ser Cys Gly Asn  Pro Gly Thr Pro Thr  Asn Gly Met 
    2975                 2980                 2985             


Ile Val  Ser Ser Asp Gly Ile  Leu Phe Ser Ser Ser  Val Ile Tyr 
    2990                 2995                 3000             


Ala Cys  Trp Glu Gly Tyr Lys  Thr Ser Gly Leu Met  Thr Arg His 
    3005                 3010                 3015             


Cys Thr  Ala Asn Gly Thr Trp  Thr Gly Thr Ala Pro  Asp Cys Thr 
    3020                 3025                 3030             


Ile Ile  Ser Cys Gly Asp Pro  Gly Thr Leu Ala Asn  Gly Ile Gln 
    3035                 3040                 3045             


Phe Gly  Thr Asp Phe Thr Phe  Asn Lys Thr Val Ser  Tyr Gln Cys 
    3050                 3055                 3060             


Asn Pro  Gly Tyr Val Met Glu  Ala Val Thr Ser Ala  Thr Ile Arg 
    3065                 3070                 3075             


Cys Thr  Lys Asp Gly Arg Trp  Asn Pro Ser Lys Pro  Val Cys Lys 
    3080                 3085                 3090             


Ala Val  Leu Cys Pro Gln Pro  Pro Pro Val Gln Asn  Gly Thr Val 
    3095                 3100                 3105             


Glu Gly  Ser Asp Phe Arg Trp  Gly Ser Ser Ile Ser  Tyr Ser Cys 
    3110                 3115                 3120             


Met Asp  Gly Tyr Gln Leu Ser  His Ser Ala Ile Leu  Ser Cys Glu 
    3125                 3130                 3135             


Gly Arg  Gly Val Trp Lys Gly  Glu Ile Pro Gln Cys  Leu Pro Val 
    3140                 3145                 3150             


Phe Cys  Gly Asp Pro Gly Ile  Pro Ala Glu Gly Arg  Leu Ser Gly 
    3155                 3160                 3165             


Lys Ser  Phe Thr Tyr Lys Ser  Glu Val Phe Phe Gln  Cys Lys Ser 
    3170                 3175                 3180             


Pro Phe  Ile Leu Val Gly Ser  Ser Arg Arg Val Cys  Gln Ala Asp 
    3185                 3190                 3195             


Gly Thr  Trp Ser Gly Ile Gln  Pro Thr Cys Ile Asp  Pro Ala His 
    3200                 3205                 3210             


Asn Thr  Cys Pro Asp Pro Gly  Thr Pro His Phe Gly  Ile Gln Asn 
    3215                 3220                 3225             


Ser Ser  Arg Gly Tyr Glu Val  Gly Ser Thr Val Phe  Phe Arg Cys 
    3230                 3235                 3240             


Arg Lys  Gly Tyr His Ile Gln  Gly Ser Thr Thr Arg  Thr Cys Leu 
    3245                 3250                 3255             


Ala Asn  Leu Thr Trp Ser Gly  Ile Gln Thr Glu Cys  Ile Pro His 
    3260                 3265                 3270             


Ala Cys  Arg Gln Pro Glu Thr  Pro Ala His Ala Asp  Val Arg Ala 
    3275                 3280                 3285             


Ile Asp  Leu Pro Thr Phe Gly  Tyr Thr Leu Val Tyr  Thr Cys His 
    3290                 3295                 3300             


Pro Gly  Phe Phe Leu Ala Gly  Gly Ser Glu His Arg  Thr Cys Lys 
    3305                 3310                 3315             


Ala Asp  Met Lys Trp Thr Gly  Lys Ser Pro Val Cys  Lys Ser Lys 
    3320                 3325                 3330             


Gly Val  Arg Glu Val Asn Glu  Thr Val Thr Lys Thr  Pro Val Pro 
    3335                 3340                 3345             


Ser Asp  Val Phe Phe Val Asn  Ser Leu Trp Lys Gly  Tyr Tyr Glu 
    3350                 3355                 3360             


Tyr Leu  Gly Lys Arg Gln Pro  Ala Thr Leu Thr Val  Asp Trp Phe 
    3365                 3370                 3375             


Asn Ala  Thr Ser Ser Lys Val  Asn Ala Thr Phe Ser  Glu Ala Ser 
    3380                 3385                 3390             


Pro Val  Glu Leu Lys Leu Thr  Gly Ile Tyr Lys Lys  Glu Glu Ala 
    3395                 3400                 3405             


His Leu  Leu Leu Lys Ala Phe  Gln Ile Lys Gly Gln  Ala Asp Ile 
    3410                 3415                 3420             


Phe Val  Ser Lys Phe Glu Asn  Asp Asn Trp Gly Leu  Asp Gly Tyr 
    3425                 3430                 3435             


Val Ser  Ser Gly Leu Glu Arg  Gly Gly Phe Thr Phe  Gln Gly Asp 
    3440                 3445                 3450             


Ile His  Gly Lys Asp Phe Gly  Lys Phe Lys Leu Glu  Arg Gln Asp 
    3455                 3460                 3465             


Pro Leu  Asn Pro Asp Gln Asp  Ser Ser Ser His Tyr  His Gly Thr 
    3470                 3475                 3480             


Ser Ser  Gly Ser Val Ala Ala  Ala Ile Leu Val Pro  Phe Phe Ala 
    3485                 3490                 3495             


Leu Ile  Leu Ser Gly Phe Ala  Phe Tyr Leu Tyr Lys  His Arg Thr 
    3500                 3505                 3510             


Arg Pro  Lys Val Gln Tyr Asn  Gly Tyr Ala Gly His  Glu Asn Ser 
    3515                 3520                 3525             


Asn Gly  Gln Ala Ser Phe Glu  Asn Pro Met Tyr Asp  Thr Asn Leu 
    3530                 3535                 3540             


Lys Pro  Thr Glu Ala Lys Ala  Val Arg Phe Asp Thr  Thr Leu Asn 
    3545                 3550                 3555             


Thr Val  Cys Thr Val Val 
    3560                 


<210>  5473
<211>  1359
<212>  PRT
<213>  Homo sapiens

<400>  5473

Met Val Gly Glu Gly Pro Tyr Leu Ile Ser Asp Leu Asp Gln Arg Gly 
1               5                   10                  15      


Arg Arg Arg Ser Phe Ala Glu Arg Tyr Asp Pro Ser Leu Lys Thr Met 
            20                  25                  30          


Ile Pro Val Arg Pro Cys Ala Arg Leu Ala Pro Asn Pro Val Asp Asp 
        35                  40                  45              


Ala Gly Leu Leu Ser Phe Ala Thr Phe Ser Trp Leu Thr Pro Val Met 
    50                  55                  60                  


Val Lys Gly Tyr Arg Gln Arg Leu Thr Val Asp Thr Leu Pro Pro Leu 
65                  70                  75                  80  


Ser Thr Tyr Asp Ser Ser Asp Thr Asn Ala Lys Arg Phe Arg Val Leu 
                85                  90                  95      


Trp Asp Glu Glu Val Ala Arg Val Gly Pro Glu Lys Ala Ser Leu Ser 
            100                 105                 110         


His Val Val Trp Lys Phe Gln Arg Thr Arg Val Leu Met Asp Ile Val 
        115                 120                 125             


Ala Asn Ile Leu Cys Ile Ile Met Ala Ala Ile Gly Pro Val Ile Leu 
    130                 135                 140                 


Ile His Gln Ile Leu Gln Gln Thr Glu Arg Thr Ser Gly Lys Val Trp 
145                 150                 155                 160 


Val Gly Ile Gly Leu Cys Ile Ala Leu Phe Ala Thr Glu Phe Thr Lys 
                165                 170                 175     


Val Phe Phe Trp Ala Leu Ala Trp Ala Ile Asn Tyr Arg Thr Ala Ile 
            180                 185                 190         


Arg Leu Lys Val Ala Leu Ser Thr Leu Val Phe Glu Asn Leu Val Ser 
        195                 200                 205             


Phe Lys Thr Leu Thr His Ile Ser Val Gly Glu Val Leu Asn Ile Leu 
    210                 215                 220                 


Ser Ser Asp Ser Tyr Ser Leu Phe Glu Ala Ala Leu Phe Cys Pro Leu 
225                 230                 235                 240 


Pro Ala Thr Ile Pro Ile Leu Met Val Phe Cys Ala Ala Tyr Ala Phe 
                245                 250                 255     


Phe Ile Leu Gly Pro Thr Ala Leu Ile Gly Ile Ser Val Tyr Val Ile 
            260                 265                 270         


Phe Ile Pro Val Gln Met Phe Met Ala Lys Leu Asn Ser Ala Phe Arg 
        275                 280                 285             


Arg Ser Ala Ile Leu Val Thr Asp Lys Arg Val Gln Thr Met Asn Glu 
    290                 295                 300                 


Phe Leu Thr Cys Ile Arg Leu Ile Lys Met Tyr Ala Trp Glu Lys Ser 
305                 310                 315                 320 


Phe Thr Asn Thr Ile Gln Asp Ile Arg Arg Arg Glu Arg Lys Leu Leu 
                325                 330                 335     


Glu Lys Ala Gly Phe Val Gln Ser Gly Asn Ser Ala Leu Ala Pro Ile 
            340                 345                 350         


Val Ser Thr Ile Ala Ile Val Leu Thr Leu Ser Cys His Ile Leu Leu 
        355                 360                 365             


Arg Arg Lys Leu Thr Ala Pro Val Ala Phe Ser Val Ile Ala Met Phe 
    370                 375                 380                 


Asn Val Met Lys Phe Ser Ile Ala Ile Leu Pro Phe Ser Ile Lys Ala 
385                 390                 395                 400 


Met Ala Glu Ala Asn Val Ser Leu Arg Arg Met Lys Lys Ile Leu Ile 
                405                 410                 415     


Asp Lys Ser Pro Pro Ser Tyr Ile Thr Gln Pro Glu Asp Pro Asp Thr 
            420                 425                 430         


Val Leu Leu Leu Ala Asn Ala Thr Leu Thr Trp Glu His Glu Ala Ser 
        435                 440                 445             


Arg Lys Ser Thr Pro Lys Lys Leu Gln Asn Gln Lys Arg His Leu Cys 
    450                 455                 460                 


Lys Lys Gln Arg Ser Glu Ala Tyr Ser Glu Arg Ser Pro Pro Ala Lys 
465                 470                 475                 480 


Gly Ala Thr Gly Pro Glu Glu Gln Ser Asp Ser Leu Lys Ser Val Leu 
                485                 490                 495     


His Ser Ile Ser Phe Val Val Arg Lys Gly Lys Ile Leu Gly Ile Cys 
            500                 505                 510         


Gly Asn Val Gly Ser Gly Lys Ser Ser Leu Leu Ala Ala Leu Leu Gly 
        515                 520                 525             


Gln Met Gln Leu Gln Lys Gly Val Val Ala Val Asn Gly Thr Leu Ala 
    530                 535                 540                 


Tyr Val Ser Gln Gln Ala Trp Ile Phe His Gly Asn Val Arg Glu Asn 
545                 550                 555                 560 


Ile Leu Phe Gly Glu Lys Tyr Asp His Gln Arg Tyr Gln His Thr Val 
                565                 570                 575     


Arg Val Cys Gly Leu Gln Lys Asp Leu Ser Asn Leu Pro Tyr Gly Asp 
            580                 585                 590         


Leu Thr Glu Ile Gly Glu Arg Gly Leu Asn Leu Ser Gly Gly Gln Arg 
        595                 600                 605             


Gln Arg Ile Ser Leu Ala Arg Ala Val Tyr Ser Asp Arg Gln Leu Tyr 
    610                 615                 620                 


Leu Leu Asp Asp Pro Leu Ser Ala Val Asp Ala His Val Gly Lys His 
625                 630                 635                 640 


Val Phe Glu Glu Cys Ile Lys Lys Thr Leu Arg Gly Lys Thr Val Val 
                645                 650                 655     


Leu Val Thr His Gln Leu Gln Phe Leu Glu Ser Cys Asp Glu Val Ile 
            660                 665                 670         


Leu Leu Glu Asp Gly Glu Ile Cys Glu Lys Gly Thr His Lys Glu Leu 
        675                 680                 685             


Met Glu Glu Arg Gly Arg Tyr Ala Lys Leu Ile His Asn Leu Arg Gly 
    690                 695                 700                 


Leu Gln Phe Lys Asp Pro Glu His Leu Tyr Asn Ala Ala Met Val Glu 
705                 710                 715                 720 


Ala Phe Lys Glu Ser Pro Ala Glu Arg Glu Glu Asp Ala Gly Ile Ile 
                725                 730                 735     


Val Leu Ala Pro Gly Asn Glu Lys Asp Glu Gly Lys Glu Ser Glu Thr 
            740                 745                 750         


Gly Ser Glu Phe Val Asp Thr Lys Val Pro Glu His Gln Leu Ile Gln 
        755                 760                 765             


Thr Glu Ser Pro Gln Glu Gly Thr Val Thr Trp Lys Thr Tyr His Thr 
    770                 775                 780                 


Tyr Ile Lys Ala Ser Gly Gly Tyr Leu Leu Ser Leu Phe Thr Val Phe 
785                 790                 795                 800 


Leu Phe Leu Leu Met Ile Gly Ser Ala Ala Phe Ser Asn Trp Trp Leu 
                805                 810                 815     


Gly Leu Trp Leu Asp Lys Gly Ser Arg Met Thr Cys Gly Pro Gln Gly 
            820                 825                 830         


Asn Arg Thr Met Cys Glu Val Gly Ala Val Leu Ala Asp Ile Gly Gln 
        835                 840                 845             


His Val Tyr Gln Trp Val Tyr Thr Ala Ser Met Val Phe Met Leu Val 
    850                 855                 860                 


Phe Gly Val Thr Lys Gly Phe Val Phe Thr Lys Thr Thr Leu Met Ala 
865                 870                 875                 880 


Ser Ser Ser Leu His Asp Thr Val Phe Asp Lys Ile Leu Lys Ser Pro 
                885                 890                 895     


Met Ser Phe Phe Asp Thr Thr Pro Thr Gly Arg Leu Met Asn Arg Phe 
            900                 905                 910         


Ser Lys Asp Met Asp Glu Leu Asp Val Arg Leu Pro Phe His Ala Glu 
        915                 920                 925             


Asn Phe Leu Gln Gln Phe Phe Met Val Val Phe Ile Leu Val Ile Leu 
    930                 935                 940                 


Ala Ala Val Phe Pro Ala Val Leu Leu Val Val Ala Ser Leu Ala Val 
945                 950                 955                 960 


Gly Phe Phe Ile Leu Leu Arg Ile Phe His Arg Gly Val Gln Glu Leu 
                965                 970                 975     


Lys Lys Val Glu Asn Val Ser Arg Ser Pro Trp Phe Thr His Ile Thr 
            980                 985                 990         


Ser Ser Met Gln Gly Leu Gly Ile  Ile His Ala Tyr Gly  Lys Lys Glu 
        995                 1000                 1005             


Ser Cys  Ile Thr Tyr His Leu  Leu Tyr Phe Asn Cys  Ala Leu Arg 
    1010                 1015                 1020             


Trp Phe  Ala Leu Arg Met Asp  Val Leu Met Asn Ile  Leu Thr Phe 
    1025                 1030                 1035             


Thr Val  Ala Leu Leu Val Thr  Leu Ser Phe Ser Ser  Ile Ser Thr 
    1040                 1045                 1050             


Ser Ser  Lys Gly Leu Ser Leu  Ser Tyr Ile Ile Gln  Leu Ser Gly 
    1055                 1060                 1065             


Leu Leu  Gln Val Cys Val Arg  Thr Gly Thr Glu Thr  Gln Ala Lys 
    1070                 1075                 1080             


Phe Thr  Ser Val Glu Leu Leu  Arg Glu Tyr Ile Ser  Thr Cys Val 
    1085                 1090                 1095             


Pro Glu  Cys Thr His Pro Leu  Lys Val Gly Thr Cys  Pro Lys Asp 
    1100                 1105                 1110             


Trp Pro  Ser Arg Gly Glu Ile  Thr Phe Arg Asp Tyr  Gln Met Arg 
    1115                 1120                 1125             


Tyr Arg  Asp Asn Thr Pro Leu  Val Leu Asp Ser Leu  Asn Leu Asn 
    1130                 1135                 1140             


Ile Gln  Ser Gly Gln Thr Val  Gly Ile Val Gly Arg  Thr Gly Ser 
    1145                 1150                 1155             


Gly Lys  Ser Ser Leu Gly Met  Ala Leu Phe Arg Leu  Val Glu Pro 
    1160                 1165                 1170             


Ala Ser  Gly Thr Ile Phe Ile  Asp Glu Val Asp Ile  Cys Ile Leu 
    1175                 1180                 1185             


Ser Leu  Glu Asp Leu Arg Thr  Lys Leu Thr Val Ile  Pro Gln Asp 
    1190                 1195                 1200             


Pro Val  Leu Phe Val Gly Thr  Val Arg Tyr Asn Leu  Asp Pro Phe 
    1205                 1210                 1215             


Glu Ser  His Thr Asp Glu Met  Leu Trp Gln Val Leu  Glu Arg Thr 
    1220                 1225                 1230             


Phe Met  Arg Asp Thr Ile Met  Lys Leu Pro Glu Lys  Leu Gln Ala 
    1235                 1240                 1245             


Glu Val  Thr Glu Asn Gly Glu  Asn Phe Ser Val Gly  Glu Arg Gln 
    1250                 1255                 1260             


Leu Leu  Cys Val Ala Arg Ala  Leu Leu Arg Asn Ser  Lys Ile Ile 
    1265                 1270                 1275             


Leu Leu  Asp Glu Ala Thr Ala  Ser Met Asp Ser Lys  Thr Asp Thr 
    1280                 1285                 1290             


Leu Val  Gln Asn Thr Ile Lys  Asp Ala Phe Lys Gly  Cys Thr Val 
    1295                 1300                 1305             


Leu Thr  Ile Ala His Arg Leu  Asn Thr Val Leu Asn  Cys Asp His 
    1310                 1315                 1320             


Val Leu  Val Met Glu Asn Gly  Lys Val Ile Glu Phe  Asp Lys Pro 
    1325                 1330                 1335             


Glu Val  Leu Ala Glu Lys Pro  Asp Ser Ala Phe Ala  Met Leu Leu 
    1340                 1345                 1350             


Ala Ala  Glu Val Arg Leu 
    1355                 


<210>  5474
<211>  1114
<212>  PRT
<213>  Homo sapiens

<400>  5474

Met Leu Arg Gly Thr Met Thr Ala Trp Arg Gly Met Arg Pro Glu Val 
1               5                   10                  15      


Thr Leu Ala Cys Leu Leu Leu Ala Thr Ala Gly Cys Phe Ala Asp Leu 
            20                  25                  30          


Asn Glu Val Pro Gln Val Thr Val Gln Pro Ala Ser Thr Val Gln Lys 
        35                  40                  45              


Pro Gly Gly Thr Val Ile Leu Gly Cys Val Val Glu Pro Pro Arg Met 
    50                  55                  60                  


Asn Val Thr Trp Arg Leu Asn Gly Lys Glu Leu Asn Gly Ser Asp Asp 
65                  70                  75                  80  


Ala Leu Gly Val Leu Ile Thr His Gly Thr Leu Val Ile Thr Ala Leu 
                85                  90                  95      


Asn Asn His Thr Val Gly Arg Tyr Gln Cys Val Ala Arg Met Pro Ala 
            100                 105                 110         


Gly Ala Val Ala Ser Val Pro Ala Thr Val Thr Leu Ala Asn Leu Gln 
        115                 120                 125             


Asp Phe Lys Leu Asp Val Gln His Val Ile Glu Val Asp Glu Gly Asn 
    130                 135                 140                 


Thr Ala Val Ile Ala Cys His Leu Pro Glu Ser His Pro Lys Ala Gln 
145                 150                 155                 160 


Val Arg Tyr Ser Val Lys Gln Glu Trp Leu Glu Ala Ser Arg Gly Asn 
                165                 170                 175     


Tyr Leu Ile Met Pro Ser Gly Asn Leu Gln Ile Val Asn Ala Ser Gln 
            180                 185                 190         


Glu Asp Glu Gly Met Tyr Lys Cys Ala Ala Tyr Asn Pro Val Thr Gln 
        195                 200                 205             


Glu Val Lys Thr Ser Gly Ser Ser Asp Arg Leu Arg Val Arg Arg Ser 
    210                 215                 220                 


Thr Ala Glu Ala Ala Arg Ile Ile Tyr Pro Pro Glu Ala Gln Thr Ile 
225                 230                 235                 240 


Ile Val Thr Lys Gly Gln Ser Leu Ile Leu Glu Cys Val Ala Ser Gly 
                245                 250                 255     


Ile Pro Pro Pro Arg Val Thr Trp Ala Lys Asp Gly Ser Ser Val Thr 
            260                 265                 270         


Gly Tyr Asn Lys Thr Arg Phe Leu Leu Ser Asn Leu Leu Ile Asp Thr 
        275                 280                 285             


Thr Ser Glu Glu Asp Ser Gly Thr Tyr Arg Cys Met Ala Asp Asn Gly 
    290                 295                 300                 


Val Gly Gln Pro Gly Ala Ala Val Ile Leu Tyr Asn Val Gln Val Phe 
305                 310                 315                 320 


Glu Pro Pro Glu Val Thr Met Glu Leu Ser Gln Leu Val Ile Pro Trp 
                325                 330                 335     


Gly Gln Ser Ala Lys Leu Thr Cys Glu Val Arg Gly Asn Pro Pro Pro 
            340                 345                 350         


Ser Val Leu Trp Leu Arg Asn Ala Val Pro Leu Ile Ser Ser Gln Arg 
        355                 360                 365             


Leu Arg Leu Ser Arg Arg Ala Leu Arg Val Leu Ser Met Gly Pro Glu 
    370                 375                 380                 


Asp Glu Gly Val Tyr Gln Cys Met Ala Glu Asn Glu Val Gly Ser Ala 
385                 390                 395                 400 


His Ala Val Val Gln Leu Arg Thr Ser Arg Pro Ser Ile Thr Pro Arg 
                405                 410                 415     


Leu Trp Gln Asp Ala Glu Leu Ala Thr Gly Thr Pro Pro Val Ser Pro 
            420                 425                 430         


Ser Lys Leu Gly Asn Pro Glu Gln Met Leu Arg Gly Gln Pro Ala Leu 
        435                 440                 445             


Pro Arg Pro Pro Thr Ser Val Gly Pro Ala Ser Pro Gln Cys Pro Gly 
    450                 455                 460                 


Glu Lys Gly Gln Gly Ala Pro Ala Glu Ala Pro Ile Ile Leu Ser Ser 
465                 470                 475                 480 


Pro Arg Thr Ser Lys Thr Asp Ser Tyr Glu Leu Val Trp Arg Pro Arg 
                485                 490                 495     


His Glu Gly Ser Gly Arg Ala Pro Ile Leu Tyr Tyr Val Val Lys His 
            500                 505                 510         


Arg Lys Val Thr Asn Ser Ser Asp Asp Trp Thr Ile Ser Gly Ile Pro 
        515                 520                 525             


Ala Asn Gln His Arg Leu Thr Leu Thr Arg Leu Asp Pro Gly Ser Leu 
    530                 535                 540                 


Tyr Glu Val Glu Met Ala Ala Tyr Asn Cys Ala Gly Glu Gly Gln Thr 
545                 550                 555                 560 


Ala Met Val Thr Phe Arg Thr Gly Arg Arg Pro Lys Pro Glu Ile Met 
                565                 570                 575     


Ala Ser Lys Glu Gln Gln Ile Gln Arg Asp Asp Pro Gly Ala Ser Pro 
            580                 585                 590         


Gln Ser Ser Ser Gln Pro Asp His Gly Arg Leu Ser Pro Pro Glu Ala 
        595                 600                 605             


Pro Asp Arg Pro Thr Ile Ser Thr Ala Ser Glu Thr Ser Val Tyr Val 
    610                 615                 620                 


Thr Trp Ile Pro Arg Gly Asn Gly Gly Phe Pro Ile Gln Ser Phe Arg 
625                 630                 635                 640 


Val Glu Tyr Lys Lys Leu Lys Lys Val Gly Asp Trp Ile Leu Ala Thr 
                645                 650                 655     


Ser Ala Ile Pro Pro Ser Arg Leu Ser Val Glu Ile Thr Gly Leu Glu 
            660                 665                 670         


Lys Gly Thr Ser Tyr Lys Phe Arg Val Arg Ala Leu Asn Met Leu Gly 
        675                 680                 685             


Glu Ser Glu Pro Ser Ala Pro Ser Arg Pro Tyr Val Val Ser Gly Tyr 
    690                 695                 700                 


Ser Gly Arg Val Tyr Glu Arg Pro Val Ala Gly Pro Tyr Ile Thr Phe 
705                 710                 715                 720 


Thr Asp Ala Val Asn Glu Thr Thr Ile Met Leu Lys Trp Met Tyr Ile 
                725                 730                 735     


Pro Ala Ser Asn Asn Asn Thr Pro Ile His Gly Phe Tyr Ile Tyr Tyr 
            740                 745                 750         


Arg Pro Thr Asp Ser Asp Asn Asp Ser Asp Tyr Lys Lys Asp Met Val 
        755                 760                 765             


Glu Gly Asp Lys Tyr Trp His Ser Ile Ser His Leu Gln Pro Glu Thr 
    770                 775                 780                 


Ser Tyr Asp Ile Lys Met Gln Cys Phe Asn Glu Gly Gly Glu Ser Glu 
785                 790                 795                 800 


Phe Ser Asn Val Met Ile Cys Glu Thr Lys Ala Arg Lys Ser Ser Gly 
                805                 810                 815     


Gln Pro Gly Arg Leu Pro Pro Pro Thr Leu Ala Pro Pro Gln Pro Pro 
            820                 825                 830         


Leu Pro Glu Thr Ile Glu Arg Pro Val Gly Thr Gly Ala Met Val Ala 
        835                 840                 845             


Arg Ser Ser Asp Leu Pro Tyr Leu Ile Val Gly Val Val Leu Gly Ser 
    850                 855                 860                 


Ile Val Leu Ile Ile Val Thr Phe Ile Pro Phe Cys Leu Trp Arg Ala 
865                 870                 875                 880 


Trp Ser Lys Gln Lys His Thr Thr Asp Leu Gly Phe Pro Arg Ser Ala 
                885                 890                 895     


Leu Pro Pro Ser Cys Pro Tyr Thr Met Val Pro Leu Gly Gly Leu Pro 
            900                 905                 910         


Gly His Gln Ala Ser Gly Gln Pro Tyr Leu Ser Gly Ile Ser Gly Arg 
        915                 920                 925             


Ala Cys Ala Asn Gly Ile His Met Asn Arg Gly Cys Pro Ser Ala Ala 
    930                 935                 940                 


Val Gly Tyr Pro Gly Met Lys Pro Gln Gln His Cys Pro Gly Glu Leu 
945                 950                 955                 960 


Gln Gln Gln Ser Asp Thr Ser Ser Leu Leu Arg Gln Thr His Leu Gly 
                965                 970                 975     


Asn Gly Tyr Asp Pro Gln Ser His Gln Ile Thr Arg Gly Pro Lys Ser 
            980                 985                 990         


Ser Pro Asp Glu Gly Ser Phe Leu  Tyr Thr Leu Pro Asp  Asp Ser Thr 
        995                 1000                 1005             


His Gln  Leu Leu Gln Pro His  His Asp Cys Cys Gln  Arg Gln Glu 
    1010                 1015                 1020             


Gln Pro  Ala Ala Val Gly Gln  Ser Gly Val Arg Arg  Ala Pro Asp 
    1025                 1030                 1035             


Ser Pro  Val Leu Glu Ala Val  Trp Asp Pro Pro Phe  His Ser Gly 
    1040                 1045                 1050             


Pro Pro  Cys Cys Leu Gly Leu  Val Pro Val Glu Glu  Val Asp Ser 
    1055                 1060                 1065             


Pro Asp  Ser Cys Gln Val Ser  Gly Gly Asp Trp Cys  Pro Gln His 
    1070                 1075                 1080             


Pro Val  Gly Ala Tyr Val Gly  Gln Glu Pro Gly Met  Gln Leu Ser 
    1085                 1090                 1095             


Pro Gly  Pro Leu Val Arg Val  Ser Phe Glu Thr Pro  Pro Leu Thr 
    1100                 1105                 1110             


Ile 
    


<210>  5475
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  5475

Met Asn Thr Arg Asn Arg Val Val Asn Ser Gly Leu Gly Ala Ser Pro 
1               5                   10                  15      


Ala Ser Arg Pro Thr Arg Asp Pro Gln Asp Pro Ser Gly Arg Gln Gly 
            20                  25                  30          


Glu Leu Ser Pro Val Glu Asp Gln Arg Glu Gly Leu Glu Ala Ala Pro 
        35                  40                  45              


Lys Gly Pro Ser Arg Glu Ser Val Val His Ala Gly Gln Arg Arg Thr 
    50                  55                  60                  


Ser Ala Tyr Thr Leu Ile Ala Pro Asn Ile Asn Arg Arg Asn Glu Ile 
65                  70                  75                  80  


Gln Arg Ile Ala Glu Gln Glu Leu Ala Asn Leu Glu Lys Trp Lys Glu 
                85                  90                  95      


Gln Asn Arg Ala Lys Pro Val His Leu Val Pro Arg Arg Leu Gly Gly 
            100                 105                 110         


Ser Gln Ser Glu Thr Glu Val Arg Gln Lys Gln Gln Leu Gln Leu Met 
        115                 120                 125             


Gln Ser Lys Tyr Lys Gln Lys Leu Lys Arg Glu Glu Ser Val Arg Ile 
    130                 135                 140                 


Lys Lys Glu Ala Glu Glu Ala Glu Leu Gln Lys Met Lys Ala Ile Gln 
145                 150                 155                 160 


Arg Glu Lys Ser Asn Lys Leu Glu Glu Lys Lys Arg Leu Gln Glu Asn 
                165                 170                 175     


Leu Arg Arg Glu Ala Phe Arg Glu His Gln Gln Tyr Lys Thr Ala Glu 
            180                 185                 190         


Phe Leu Ser Lys Leu Asn Thr Glu Ser Pro Asp Arg Ser Ala Cys Gln 
        195                 200                 205             


Ser Ala Val Cys Gly Pro Gln Ser Ser Thr Trp Ala Arg Ser Trp Ala 
    210                 215                 220                 


Tyr Arg Asp Ser Leu Lys Ala Glu Glu Asn Arg Lys Leu Gln Lys Met 
225                 230                 235                 240 


Lys Asp Glu Gln His Gln Lys Ser Glu Leu Leu Glu Leu Lys Arg Gln 
                245                 250                 255     


Gln Gln Glu Gln Glu Arg Ala Lys Ile His Gln Thr Glu His Arg Arg 
            260                 265                 270         


Val Asn Asn Ala Phe Leu Asp Arg Leu Gln Gly Lys Ser Gln Pro Gly 
        275                 280                 285             


Gly Leu Glu Gln Ser Gly Gly Cys Trp Asn Met Asn Ser Gly Asn Ser 
    290                 295                 300                 


Trp Gly Ile 
305         


<210>  5476
<211>  925
<212>  PRT
<213>  Homo sapiens

<400>  5476

Met Ala Trp Leu Arg Leu Gln Pro Leu Thr Ser Ala Phe Leu His Phe 
1               5                   10                  15      


Gly Leu Val Thr Phe Val Leu Phe Leu Asn Gly Leu Arg Ala Glu Ala 
            20                  25                  30          


Gly Gly Ser Gly Asp Val Pro Ser Thr Gly Gln Asn Asn Glu Ser Cys 
        35                  40                  45              


Ser Gly Ser Ser Asp Cys Lys Glu Gly Val Ile Leu Pro Ile Trp Tyr 
    50                  55                  60                  


Pro Glu Asn Pro Ser Leu Gly Asp Lys Ile Ala Arg Val Ile Val Tyr 
65                  70                  75                  80  


Phe Val Ala Leu Ile Tyr Met Phe Leu Gly Val Ser Ile Ile Ala Asp 
                85                  90                  95      


Arg Phe Met Ala Ser Ile Glu Val Ile Thr Ser Gln Glu Arg Glu Val 
            100                 105                 110         


Thr Ile Lys Lys Pro Asn Gly Glu Thr Ser Thr Thr Thr Ile Arg Val 
        115                 120                 125             


Trp Asn Glu Thr Val Ser Asn Leu Thr Leu Met Ala Leu Gly Ser Ser 
    130                 135                 140                 


Ala Pro Glu Ile Leu Leu Ser Leu Ile Glu Val Cys Gly His Gly Phe 
145                 150                 155                 160 


Ile Ala Gly Asp Leu Gly Pro Ser Thr Ile Val Gly Ser Ala Ala Phe 
                165                 170                 175     


Asn Met Phe Ile Ile Ile Gly Ile Cys Val Tyr Val Ile Pro Asp Gly 
            180                 185                 190         


Glu Thr Arg Lys Ile Lys His Leu Arg Val Phe Phe Ile Thr Ala Ala 
        195                 200                 205             


Trp Ser Ile Phe Ala Tyr Ile Trp Leu Tyr Met Ile Leu Ala Val Phe 
    210                 215                 220                 


Ser Pro Gly Val Val Gln Val Trp Glu Gly Leu Leu Thr Leu Phe Phe 
225                 230                 235                 240 


Phe Pro Val Cys Val Leu Leu Ala Trp Val Ala Asp Lys Arg Leu Leu 
                245                 250                 255     


Phe Tyr Lys Tyr Met His Lys Lys Tyr Arg Thr Asp Lys His Arg Gly 
            260                 265                 270         


Ile Ile Ile Glu Thr Glu Gly Asp His Pro Lys Gly Ile Glu Met Asp 
        275                 280                 285             


Gly Lys Met Met Asn Ser His Phe Leu Asp Gly Asn Leu Val Pro Leu 
    290                 295                 300                 


Glu Gly Lys Glu Val Asp Glu Ser Arg Arg Glu Met Ile Arg Ile Leu 
305                 310                 315                 320 


Lys Asp Leu Lys Gln Lys His Pro Glu Lys Asp Leu Asp Gln Leu Val 
                325                 330                 335     


Glu Met Ala Asn Tyr Tyr Ala Leu Ser His Gln Gln Lys Ser Arg Ala 
            340                 345                 350         


Phe Tyr Arg Ile Gln Ala Thr Arg Met Met Thr Gly Ala Gly Asn Ile 
        355                 360                 365             


Leu Lys Lys His Ala Ala Glu Gln Ala Lys Lys Ala Ser Ser Met Ser 
    370                 375                 380                 


Glu Val His Thr Asp Glu Pro Glu Asp Phe Ile Ser Lys Val Phe Phe 
385                 390                 395                 400 


Asp Pro Cys Ser Tyr Gln Cys Leu Glu Asn Cys Gly Ala Val Leu Leu 
                405                 410                 415     


Thr Val Val Arg Lys Gly Gly Asp Met Ser Lys Thr Met Tyr Val Asp 
            420                 425                 430         


Tyr Lys Thr Glu Asp Gly Ser Ala Asn Ala Gly Ala Asp Tyr Glu Phe 
        435                 440                 445             


Thr Glu Gly Thr Val Val Leu Lys Pro Gly Glu Thr Gln Lys Glu Phe 
    450                 455                 460                 


Ser Val Gly Ile Ile Asp Asp Asp Ile Phe Glu Glu Asp Glu His Phe 
465                 470                 475                 480 


Phe Val Arg Leu Ser Asn Val Arg Ile Glu Glu Glu Gln Pro Glu Glu 
                485                 490                 495     


Gly Met Pro Pro Ala Ile Phe Asn Ser Leu Pro Leu Pro Arg Ala Val 
            500                 505                 510         


Leu Ala Ser Pro Cys Val Ala Thr Val Thr Ile Leu Asp Asp Asp His 
        515                 520                 525             


Ala Gly Ile Phe Thr Phe Glu Cys Asp Thr Ile His Val Ser Glu Ser 
    530                 535                 540                 


Ile Gly Val Met Glu Val Lys Val Leu Arg Thr Ser Gly Ala Arg Gly 
545                 550                 555                 560 


Thr Val Ile Val Pro Phe Arg Thr Val Glu Gly Thr Ala Lys Gly Gly 
                565                 570                 575     


Gly Glu Asp Phe Glu Asp Thr Tyr Gly Glu Leu Glu Phe Lys Asn Asp 
            580                 585                 590         


Glu Thr Val Lys Thr Ile His Ile Lys Val Ile Asp Asp Glu Ala Tyr 
        595                 600                 605             


Glu Lys Asn Lys Asn Tyr Phe Ile Glu Met Met Gly Pro Arg Met Val 
    610                 615                 620                 


Asp Met Ser Phe Gln Lys Ala Leu Leu Leu Ser Pro Asp Arg Lys Leu 
625                 630                 635                 640 


Thr Met Glu Glu Glu Glu Ala Lys Arg Ile Ala Glu Met Gly Lys Pro 
                645                 650                 655     


Val Leu Gly Glu His Pro Lys Leu Glu Val Ile Ile Glu Glu Ser Tyr 
            660                 665                 670         


Glu Phe Lys Thr Thr Val Asp Lys Leu Ile Lys Lys Thr Asn Leu Ala 
        675                 680                 685             


Leu Val Val Gly Thr His Ser Trp Arg Asp Gln Phe Met Glu Ala Ile 
    690                 695                 700                 


Thr Val Ser Ala Ala Gly Asp Glu Asp Glu Asp Glu Ser Gly Glu Glu 
705                 710                 715                 720 


Arg Leu Pro Ser Cys Phe Asp Tyr Val Met His Phe Leu Thr Val Phe 
                725                 730                 735     


Trp Lys Val Leu Phe Ala Cys Val Pro Pro Thr Glu Tyr Cys His Gly 
            740                 745                 750         


Trp Ala Cys Phe Ala Val Ser Ile Leu Ile Ile Gly Met Leu Thr Ala 
        755                 760                 765             


Ile Ile Gly Asp Leu Ala Ser His Phe Gly Cys Thr Ile Gly Leu Lys 
    770                 775                 780                 


Asp Ser Val Thr Ala Val Val Phe Val Ala Phe Gly Thr Ser Val Pro 
785                 790                 795                 800 


Asp Thr Phe Ala Ser Lys Ala Ala Ala Leu Gln Asp Val Tyr Ala Asp 
                805                 810                 815     


Ala Ser Ile Gly Asn Val Thr Gly Ser Asn Ala Val Asn Val Phe Leu 
            820                 825                 830         


Gly Ile Gly Leu Ala Trp Ser Val Ala Ala Ile Tyr Trp Ala Leu Gln 
        835                 840                 845             


Gly Gln Glu Phe His Val Ser Ala Gly Thr Leu Ala Phe Ser Val Thr 
    850                 855                 860                 


Leu Phe Thr Ile Phe Ala Phe Val Cys Ile Ser Val Leu Leu Tyr Arg 
865                 870                 875                 880 


Arg Arg Pro His Leu Gly Gly Glu Leu Gly Gly Pro Arg Gly Cys Lys 
                885                 890                 895     


Leu Ala Thr Thr Trp Leu Phe Val Ser Leu Trp Leu Leu Tyr Ile Leu 
            900                 905                 910         


Phe Ala Thr Leu Glu Ala Tyr Cys Tyr Ile Lys Gly Phe 
        915                 920                 925 


<210>  5477
<211>  1196
<212>  PRT
<213>  Homo sapiens

<400>  5477

Met Pro Val Arg Arg Gly His Val Ala Pro Gln Asn Thr Phe Leu Gly 
1               5                   10                  15      


Thr Ile Ile Arg Lys Phe Glu Gly Gln Asn Lys Lys Phe Ile Ile Ala 
            20                  25                  30          


Asn Ala Arg Val Gln Asn Cys Ala Ile Ile Tyr Cys Asn Asp Gly Phe 
        35                  40                  45              


Cys Glu Met Thr Gly Phe Ser Arg Pro Asp Val Met Gln Lys Pro Cys 
    50                  55                  60                  


Thr Cys Asp Phe Leu His Gly Pro Glu Thr Lys Arg His Asp Ile Ala 
65                  70                  75                  80  


Gln Ile Ala Gln Ala Leu Leu Gly Ser Glu Glu Arg Lys Val Glu Val 
                85                  90                  95      


Thr Tyr Tyr His Lys Asn Gly Ser Thr Phe Ile Cys Asn Thr His Ile 
            100                 105                 110         


Ile Pro Val Lys Asn Gln Glu Gly Val Ala Met Met Phe Ile Ile Asn 
        115                 120                 125             


Phe Glu Tyr Val Thr Asp Asn Glu Asn Ala Ala Thr Pro Glu Arg Val 
    130                 135                 140                 


Asn Pro Ile Leu Pro Ile Lys Thr Val Asn Arg Lys Phe Phe Gly Phe 
145                 150                 155                 160 


Lys Phe Pro Gly Leu Arg Val Leu Thr Tyr Arg Lys Gln Ser Leu Pro 
                165                 170                 175     


Gln Glu Asp Pro Asp Val Val Val Ile Asp Ser Ser Lys His Ser Asp 
            180                 185                 190         


Asp Ser Val Ala Met Lys His Phe Lys Ser Pro Thr Lys Glu Ser Cys 
        195                 200                 205             


Ser Pro Ser Glu Ala Asp Asp Thr Lys Ala Leu Ile Gln Pro Ser Lys 
    210                 215                 220                 


Cys Ser Pro Leu Val Asn Ile Ser Gly Pro Leu Asp His Ser Ser Pro 
225                 230                 235                 240 


Lys Arg Gln Trp Asp Arg Leu Tyr Pro Asp Met Leu Gln Ser Ser Ser 
                245                 250                 255     


Gln Leu Ser His Ser Arg Ser Arg Glu Ser Leu Cys Ser Ile Arg Arg 
            260                 265                 270         


Ala Ser Ser Val His Asp Ile Glu Gly Phe Gly Val His Pro Lys Asn 
        275                 280                 285             


Ile Phe Arg Asp Arg His Ala Ser Glu Asp Asn Gly Arg Asn Val Lys 
    290                 295                 300                 


Gly Pro Phe Asn His Ile Lys Ser Ser Leu Leu Gly Ser Thr Ser Asp 
305                 310                 315                 320 


Ser Asn Leu Asn Lys Tyr Ser Thr Ile Asn Lys Ile Pro Gln Leu Thr 
                325                 330                 335     


Leu Asn Phe Ser Glu Val Lys Thr Glu Lys Lys Asn Ser Ser Pro Pro 
            340                 345                 350         


Ser Ser Asp Lys Thr Ile Ile Ala Pro Lys Val Lys Asp Arg Thr His 
        355                 360                 365             


Asn Val Thr Glu Lys Val Thr Gln Val Leu Ser Leu Gly Ala Asp Val 
    370                 375                 380                 


Leu Pro Glu Tyr Lys Leu Gln Thr Pro Arg Ile Asn Lys Phe Thr Ile 
385                 390                 395                 400 


Leu His Tyr Ser Pro Phe Lys Ala Val Trp Asp Trp Leu Ile Leu Leu 
                405                 410                 415     


Leu Val Ile Tyr Thr Ala Ile Phe Thr Pro Tyr Ser Ala Ala Phe Leu 
            420                 425                 430         


Leu Asn Asp Arg Glu Glu Gln Lys Arg Arg Glu Cys Gly Tyr Ser Cys 
        435                 440                 445             


Ser Pro Leu Asn Val Val Asp Leu Ile Val Asp Ile Met Phe Ile Ile 
    450                 455                 460                 


Asp Ile Leu Ile Asn Phe Arg Thr Thr Tyr Val Asn Gln Asn Glu Glu 
465                 470                 475                 480 


Val Val Ser Asp Pro Ala Lys Ile Ala Ile His Tyr Phe Lys Gly Trp 
                485                 490                 495     


Phe Leu Ile Asp Met Val Ala Ala Ile Pro Phe Asp Leu Leu Ile Phe 
            500                 505                 510         


Gly Ser Gly Ser Asp Glu Thr Thr Thr Leu Ile Gly Leu Leu Lys Thr 
        515                 520                 525             


Ala Arg Leu Leu Arg Leu Val Arg Val Ala Arg Lys Leu Asp Arg Tyr 
    530                 535                 540                 


Ser Glu Tyr Gly Ala Ala Val Leu Met Leu Leu Met Cys Ile Phe Ala 
545                 550                 555                 560 


Leu Ile Ala His Trp Leu Ala Cys Ile Trp Tyr Ala Ile Gly Asn Val 
                565                 570                 575     


Glu Arg Pro Tyr Leu Thr Asp Lys Ile Gly Trp Leu Asp Ser Leu Gly 
            580                 585                 590         


Gln Gln Ile Gly Lys Arg Tyr Asn Asp Ser Asp Ser Ser Ser Gly Pro 
        595                 600                 605             


Ser Ile Lys Asp Lys Tyr Val Thr Ala Leu Tyr Phe Thr Phe Ser Ser 
    610                 615                 620                 


Leu Thr Ser Val Gly Phe Gly Asn Val Ser Pro Asn Thr Asn Ser Glu 
625                 630                 635                 640 


Lys Ile Phe Ser Ile Cys Val Met Leu Ile Gly Ser Leu Met Tyr Ala 
                645                 650                 655     


Ser Ile Phe Gly Asn Val Ser Ala Ile Ile Gln Arg Leu Tyr Ser Gly 
            660                 665                 670         


Thr Ala Arg Tyr His Met Gln Met Leu Arg Val Lys Glu Phe Ile Arg 
        675                 680                 685             


Phe His Gln Ile Pro Asn Pro Leu Arg Gln Arg Leu Glu Glu Tyr Phe 
    690                 695                 700                 


Gln His Ala Trp Thr Tyr Thr Asn Gly Ile Asp Met Asn Met Val Leu 
705                 710                 715                 720 


Lys Gly Phe Pro Glu Cys Leu Gln Ala Asp Ile Cys Leu His Leu Asn 
                725                 730                 735     


Gln Thr Leu Leu Gln Asn Cys Lys Ala Phe Arg Gly Ala Ser Lys Gly 
            740                 745                 750         


Cys Leu Arg Ala Leu Ala Met Lys Phe Lys Thr Thr His Ala Pro Pro 
        755                 760                 765             


Gly Asp Thr Leu Val His Cys Gly Asp Val Leu Thr Ala Leu Tyr Phe 
    770                 775                 780                 


Leu Ser Arg Gly Ser Ile Glu Ile Leu Lys Asp Asp Ile Val Val Ala 
785                 790                 795                 800 


Ile Leu Gly Lys Asn Asp Ile Phe Gly Glu Met Val His Leu Tyr Ala 
                805                 810                 815     


Lys Pro Gly Lys Ser Asn Ala Asp Val Arg Ala Leu Thr Tyr Cys Asp 
            820                 825                 830         


Leu His Lys Ile Gln Arg Glu Asp Leu Leu Glu Val Leu Asp Met Tyr 
        835                 840                 845             


Pro Glu Phe Ser Asp His Phe Leu Thr Asn Leu Glu Leu Thr Phe Asn 
    850                 855                 860                 


Leu Arg His Glu Ser Ala Lys Ala Asp Leu Leu Arg Ser Gln Ser Met 
865                 870                 875                 880 


Asn Asp Ser Glu Gly Asp Asn Cys Lys Leu Arg Arg Arg Lys Leu Ser 
                885                 890                 895     


Phe Glu Ser Glu Gly Glu Lys Glu Asn Ser Thr Asn Asp Pro Glu Asp 
            900                 905                 910         


Ser Ala Asp Thr Ile Arg His Tyr Gln Ser Ser Lys Arg His Phe Glu 
        915                 920                 925             


Glu Lys Lys Ser Arg Ser Ser Ser Phe Ile Ser Ser Ile Asp Asp Glu 
    930                 935                 940                 


Gln Lys Pro Leu Phe Ser Gly Ile Val Asp Ser Ser Pro Gly Ile Gly 
945                 950                 955                 960 


Lys Ala Ser Gly Leu Asp Phe Glu Glu Thr Val Pro Thr Ser Gly Arg 
                965                 970                 975     


Met His Ile Asp Lys Arg Ser His Ser Cys Lys Asp Ile Thr Asp Met 
            980                 985                 990         


Arg Ser Trp Glu Arg Glu Asn Ala  His Pro Gln Pro Glu  Asp Ser Ser 
        995                 1000                 1005             


Pro Ser  Ala Leu Gln Arg Ala  Ala Trp Gly Ile Ser  Glu Thr Glu 
    1010                 1015                 1020             


Ser Asp  Leu Thr Tyr Gly Glu  Val Glu Gln Arg Leu  Asp Leu Leu 
    1025                 1030                 1035             


Gln Glu  Gln Leu Asn Arg Leu  Glu Ser Gln Met Thr  Thr Asp Ile 
    1040                 1045                 1050             


Gln Thr  Ile Leu Gln Leu Leu  Gln Lys Gln Thr Thr  Val Val Pro 
    1055                 1060                 1065             


Pro Ala  Tyr Ser Met Val Thr  Ala Gly Ser Glu Tyr  Gln Arg Pro 
    1070                 1075                 1080             


Ile Ile  Gln Leu Met Arg Thr  Ser Gln Pro Glu Ala  Ser Ile Lys 
    1085                 1090                 1095             


Thr Asp  Arg Ser Phe Ser Pro  Ser Ser Gln Cys Pro  Glu Phe Leu 
    1100                 1105                 1110             


Asp Leu  Glu Lys Ser Lys Leu  Lys Ser Lys Glu Ser  Leu Ser Ser 
    1115                 1120                 1125             


Gly Val  His Leu Asn Thr Ala  Ser Glu Asp Asn Leu  Thr Ser Leu 
    1130                 1135                 1140             


Leu Lys  Gln Asp Ser Asp Leu  Ser Leu Glu Leu His  Leu Arg Gln 
    1145                 1150                 1155             


Arg Lys  Thr Tyr Val His Pro  Ile Arg His Pro Ser  Leu Pro Asp 
    1160                 1165                 1170             


Ser Ser  Leu Ser Thr Val Gly  Ile Val Gly Leu His  Arg His Val 
    1175                 1180                 1185             


Ser Asp  Pro Gly Leu Pro Gly  Lys 
    1190                 1195     


<210>  5478
<211>  918
<212>  PRT
<213>  Homo sapiens

<400>  5478

Met Pro Gly Gly Ala Gly Ala Ala Arg Leu Cys Leu Leu Ala Phe Ala 
1               5                   10                  15      


Leu Gln Pro Leu Arg Pro Arg Ala Ala Arg Glu Pro Gly Trp Thr Arg 
            20                  25                  30          


Gly Ser Glu Glu Gly Ser Pro Lys Leu Gln His Glu Leu Ile Ile Pro 
        35                  40                  45              


Gln Trp Lys Thr Ser Glu Ser Pro Val Arg Glu Lys His Pro Leu Lys 
    50                  55                  60                  


Ala Glu Leu Arg Val Met Ala Glu Gly Arg Glu Leu Ile Leu Asp Leu 
65                  70                  75                  80  


Glu Lys Asn Glu Gln Leu Phe Ala Pro Ser Tyr Thr Glu Thr His Tyr 
                85                  90                  95      


Thr Ser Ser Gly Asn Pro Gln Thr Thr Thr Arg Lys Leu Glu Asp His 
            100                 105                 110         


Cys Phe Tyr His Gly Thr Val Arg Glu Thr Glu Leu Ser Ser Val Thr 
        115                 120                 125             


Leu Ser Thr Cys Arg Gly Ile Arg Gly Leu Ile Thr Val Ser Ser Asn 
    130                 135                 140                 


Leu Ser Tyr Val Ile Glu Pro Leu Pro Asp Ser Lys Gly Gln His Leu 
145                 150                 155                 160 


Ile Tyr Arg Ser Glu His Leu Lys Pro Pro Pro Gly Asn Cys Gly Phe 
                165                 170                 175     


Glu His Ser Lys Pro Thr Thr Arg Asp Trp Ala Leu Gln Phe Thr Gln 
            180                 185                 190         


Gln Thr Lys Lys Arg Pro Arg Arg Met Lys Arg Glu Asp Leu Asn Ser 
        195                 200                 205             


Met Lys Tyr Val Glu Leu Tyr Leu Val Ala Asp Tyr Leu Glu Phe Gln 
    210                 215                 220                 


Lys Asn Arg Arg Asp Gln Asp Ala Thr Lys His Lys Leu Ile Glu Ile 
225                 230                 235                 240 


Ala Asn Tyr Val Asp Lys Phe Tyr Arg Ser Leu Asn Ile Arg Ile Ala 
                245                 250                 255     


Leu Val Gly Leu Glu Val Trp Thr His Gly Asn Met Cys Glu Val Ser 
            260                 265                 270         


Glu Asn Pro Tyr Ser Thr Leu Trp Ser Phe Leu Ser Trp Arg Arg Lys 
        275                 280                 285             


Leu Leu Ala Gln Lys Tyr His Asp Asn Ala Gln Leu Ile Thr Gly Met 
    290                 295                 300                 


Ser Phe His Gly Thr Thr Ile Gly Leu Ala Pro Leu Met Ala Met Cys 
305                 310                 315                 320 


Ser Val Tyr Gln Ser Gly Gly Val Asn Met Asp His Ser Glu Asn Ala 
                325                 330                 335     


Ile Gly Val Ala Ala Thr Met Ala His Glu Met Gly His Asn Phe Gly 
            340                 345                 350         


Met Thr His Asp Ser Ala Asp Cys Cys Ser Ala Ser Ala Ala Asp Gly 
        355                 360                 365             


Gly Cys Ile Met Ala Ala Ala Thr Gly His Pro Phe Pro Lys Val Phe 
    370                 375                 380                 


Asn Gly Cys Asn Arg Arg Glu Leu Asp Arg Tyr Leu Gln Ser Gly Gly 
385                 390                 395                 400 


Gly Met Cys Leu Ser Asn Met Pro Asp Thr Arg Met Leu Tyr Gly Gly 
                405                 410                 415     


Arg Arg Cys Gly Asn Gly Tyr Leu Glu Asp Gly Glu Glu Cys Asp Cys 
            420                 425                 430         


Gly Glu Glu Glu Glu Cys Asn Asn Pro Cys Cys Asn Ala Ser Asn Cys 
        435                 440                 445             


Thr Leu Arg Pro Gly Ala Glu Cys Ala His Gly Ser Cys Cys His Gln 
    450                 455                 460                 


Cys Lys Leu Leu Ala Pro Gly Thr Leu Cys Arg Glu Gln Ala Arg Gln 
465                 470                 475                 480 


Cys Asp Leu Pro Glu Phe Cys Thr Gly Lys Ser Pro His Cys Pro Thr 
                485                 490                 495     


Asn Phe Tyr Gln Met Asp Gly Thr Pro Cys Glu Gly Gly Gln Ala Tyr 
            500                 505                 510         


Cys Tyr Asn Gly Met Cys Leu Thr Tyr Gln Glu Gln Cys Gln Gln Leu 
        515                 520                 525             


Trp Gly Pro Gly Ala Arg Pro Ala Pro Asp Leu Cys Phe Glu Lys Val 
    530                 535                 540                 


Asn Val Ala Gly Asp Thr Phe Gly Asn Cys Gly Lys Asp Met Asn Gly 
545                 550                 555                 560 


Glu His Arg Lys Cys Asn Met Arg Asp Ala Lys Cys Gly Lys Ile Gln 
                565                 570                 575     


Cys Gln Ser Ser Glu Ala Arg Pro Leu Glu Ser Asn Ala Val Pro Ile 
            580                 585                 590         


Asp Thr Thr Ile Ile Met Asn Gly Arg Gln Ile Gln Cys Arg Gly Thr 
        595                 600                 605             


His Val Tyr Arg Gly Pro Glu Glu Glu Gly Asp Met Leu Asp Pro Gly 
    610                 615                 620                 


Leu Val Met Thr Gly Thr Lys Cys Gly Tyr Asn His Ile Cys Phe Glu 
625                 630                 635                 640 


Gly Gln Cys Arg Asn Thr Ser Phe Phe Glu Thr Glu Gly Cys Gly Lys 
                645                 650                 655     


Lys Cys Asn Gly His Gly Val Cys Asn Asn Asn Gln Asn Cys His Cys 
            660                 665                 670         


Leu Pro Gly Trp Ala Pro Pro Phe Cys Asn Thr Pro Gly His Gly Gly 
        675                 680                 685             


Ser Ile Asp Ser Gly Pro Met Pro Pro Glu Ser Val Gly Pro Val Val 
    690                 695                 700                 


Ala Gly Val Leu Val Ala Ile Leu Val Leu Ala Val Leu Met Leu Met 
705                 710                 715                 720 


Tyr Tyr Cys Cys Arg Gln Asn Asn Lys Leu Gly Gln Leu Lys Pro Ser 
                725                 730                 735     


Ala Leu Pro Ser Lys Leu Arg Gln Gln Phe Ser Cys Pro Phe Arg Val 
            740                 745                 750         


Ser Gln Asn Ser Gly Thr Gly His Ala Asn Pro Thr Phe Lys Leu Gln 
        755                 760                 765             


Thr Pro Gln Gly Lys Arg Lys Val Ile Asn Thr Pro Glu Ile Leu Arg 
    770                 775                 780                 


Lys Pro Ser Gln Pro Pro Pro Arg Pro Pro Pro Asp Tyr Leu Arg Gly 
785                 790                 795                 800 


Gly Ser Pro Pro Ala Pro Leu Pro Ala His Leu Ser Arg Ala Ala Arg 
                805                 810                 815     


Asn Ser Pro Gly Pro Gly Ser Gln Ile Glu Arg Thr Glu Ser Ser Arg 
            820                 825                 830         


Arg Pro Pro Pro Ser Arg Pro Ile Pro Pro Ala Pro Asn Cys Ile Val 
        835                 840                 845             


Ser Gln Asp Phe Ser Arg Pro Arg Pro Pro Gln Lys Ala Leu Pro Ala 
    850                 855                 860                 


Asn Pro Val Pro Gly Arg Arg Ser Leu Pro Arg Pro Gly Gly Ala Ser 
865                 870                 875                 880 


Pro Leu Arg Pro Pro Gly Ala Gly Pro Gln Gln Ser Arg Pro Leu Ala 
                885                 890                 895     


Ala Leu Ala Pro Lys Phe Pro Glu Tyr Arg Ser Gln Arg Ala Gly Gly 
            900                 905                 910         


Met Ile Ser Ser Lys Ile 
        915             


<210>  5479
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  5479

Met Val Arg Ala Gly Ala Val Gly Ala His Leu Pro Ala Ser Gly Leu 
1               5                   10                  15      


Asp Ile Phe Gly Asp Leu Lys Lys Met Asn Lys Arg Gln Leu Tyr Tyr 
            20                  25                  30          


Gln Val Leu Asn Phe Ala Met Ile Val Ser Ser Ala Leu Met Ile Trp 
        35                  40                  45              


Lys Gly Leu Ile Val Leu Thr Gly Ser Glu Ser Pro Ile Val Val Val 
    50                  55                  60                  


Leu Ser Gly Ser Met Glu Pro Ala Phe His Arg Gly Asp Leu Leu Phe 
65                  70                  75                  80  


Leu Thr Asn Phe Arg Glu Asp Pro Ile Arg Ala Gly Glu Ile Val Val 
                85                  90                  95      


Phe Lys Val Glu Gly Arg Asp Ile Pro Ile Val His Arg Val Ile Lys 
            100                 105                 110         


Val His Glu Lys Asp Asn Gly Asp Ile Lys Phe Leu Thr Lys Gly Asp 
        115                 120                 125             


Asn Asn Glu Val Asp Asp Arg Gly Leu Tyr Lys Glu Gly Gln Asn Trp 
    130                 135                 140                 


Leu Glu Lys Lys Asp Val Val Gly Arg Ala Arg Gly Phe Leu Pro Tyr 
145                 150                 155                 160 


Val Gly Met Val Thr Ile Ile Met Asn Asp Tyr Pro Lys Phe Lys Tyr 
                165                 170                 175     


Ala Leu Leu Ala Val Met Gly Ala Tyr Val Leu Leu Lys Arg Glu Ser 
            180                 185                 190         


<210>  5480
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  5480

Met Asn Pro Pro Ser Gly Pro Arg Val Pro Pro Ser Pro Thr Gln Glu 
1               5                   10                  15      


Pro Ser Cys Met Ala Thr Pro Ala Pro Pro Ser Trp Trp Asp Ser Ser 
            20                  25                  30          


Gln Ser Ser Ile Ser Ser Leu Gly Arg Leu Pro Ser Ile Ser Pro Thr 
        35                  40                  45              


Ala Pro Gly Thr Trp Ala Ala Ala Trp Val Pro Leu Pro Thr Val Asp 
    50                  55                  60                  


Val Pro Asp His Ala His Tyr Thr Leu Gly Thr Val Ile Leu Leu Val 
65                  70                  75                  80  


Gly Leu Thr Gly Met Leu Gly Asn Leu Thr Val Ile Tyr Thr Phe Cys 
                85                  90                  95      


Arg Ser Arg Ser Leu Arg Thr Pro Ala Asn Met Phe Ile Ile Asn Leu 
            100                 105                 110         


Ala Val Ser Asp Phe Leu Met Ser Phe Thr Gln Ala Pro Val Phe Phe 
        115                 120                 125             


Thr Ser Ser Leu Tyr Lys Gln Trp Leu Phe Gly Glu Thr Gly Cys Glu 
    130                 135                 140                 


Phe Tyr Ala Phe Cys Gly Ala Leu Phe Gly Ile Ser Ser Met Ile Thr 
145                 150                 155                 160 


Leu Thr Ala Ile Ala Leu Asp Arg Tyr Leu Val Ile Thr Arg Pro Leu 
                165                 170                 175     


Ala Thr Phe Gly Val Ala Ser Lys Arg Arg Ala Ala Phe Val Leu Leu 
            180                 185                 190         


Gly Val Trp Leu Tyr Ala Leu Ala Trp Ser Leu Pro Pro Phe Phe Gly 
        195                 200                 205             


Trp Ser Ala Tyr Val Pro Glu Gly Leu Leu Thr Ser Cys Ser Trp Asp 
    210                 215                 220                 


Tyr Met Ser Phe Thr Pro Ala Val Arg Ala Tyr Thr Met Leu Leu Cys 
225                 230                 235                 240 


Cys Phe Val Phe Phe Leu Pro Leu Leu Ile Ile Ile Tyr Cys Tyr Ile 
                245                 250                 255     


Phe Ile Phe Arg Ala Ile Arg Glu Thr Gly Arg Ala Leu Gln Thr Phe 
            260                 265                 270         


Gly Ala Cys Lys Gly Asn Gly Glu Ser Leu Trp Gln Arg Gln Arg Leu 
        275                 280                 285             


Gln Ser Glu Cys Lys Met Ala Lys Ile Met Leu Leu Val Ile Leu Leu 
    290                 295                 300                 


Phe Val Leu Ser Trp Ala Pro Tyr Ser Ala Val Ala Leu Val Ala Phe 
305                 310                 315                 320 


Ala Gly Tyr Ala His Val Leu Thr Pro Tyr Met Ser Ser Val Pro Ala 
                325                 330                 335     


Val Ile Ala Lys Ala Ser Ala Ile His Asn Pro Ile Ile Tyr Ala Ile 
            340                 345                 350         


Thr His Pro Lys Tyr Arg Val Ala Ile Ala Gln His Leu Pro Cys Leu 
        355                 360                 365             


Gly Val Leu Leu Gly Val Ser Arg Arg His Ser Arg Pro Tyr Pro Ser 
    370                 375                 380                 


Tyr Arg Ser Thr His Arg Ser Thr Leu Thr Ser His Thr Ser Asn Leu 
385                 390                 395                 400 


Ser Trp Ile Ser Ile Arg Arg Arg Gln Glu Ser Leu Gly Ser Glu Ser 
                405                 410                 415     


Glu Val Gly Trp Thr His Met Glu Ala Ala Ala Val Trp Gly Ala Ala 
            420                 425                 430         


Gln Gln Ala Asn Gly Arg Ser Leu Tyr Gly Gln Gly Leu Glu Asp Leu 
        435                 440                 445             


Glu Ala Lys Ala Pro Pro Arg Pro Gln Gly His Glu Ala Glu Thr Pro 
    450                 455                 460                 


Gly Lys Thr Lys Gly Leu Ile Pro Ser Gln Asp Pro Arg Met 
465                 470                 475             


<210>  5481
<211>  667
<212>  PRT
<213>  Homo sapiens

<400>  5481

Met Glu Thr Leu Glu Ser Glu Leu Thr Cys Pro Ile Cys Leu Glu Leu 
1               5                   10                  15      


Phe Glu Asp Pro Leu Leu Leu Pro Cys Ala His Ser Leu Cys Phe Asn 
            20                  25                  30          


Cys Ala His Arg Ile Leu Val Ser His Cys Ala Thr Asn Glu Ser Val 
        35                  40                  45              


Glu Ser Ile Thr Ala Phe Gln Cys Pro Thr Cys Arg His Val Ile Thr 
    50                  55                  60                  


Leu Ser Gln Arg Gly Leu Asp Gly Leu Lys Arg Asn Val Thr Leu Gln 
65                  70                  75                  80  


Asn Ile Ile Asp Arg Phe Gln Lys Ala Ser Val Ser Gly Pro Asn Ser 
                85                  90                  95      


Pro Ser Glu Thr Arg Arg Glu Arg Ala Phe Asp Ala Asn Thr Met Thr 
            100                 105                 110         


Ser Ala Glu Lys Val Leu Cys Gln Phe Cys Asp Gln Asp Pro Ala Gln 
        115                 120                 125             


Asp Ala Val Lys Thr Cys Val Thr Cys Glu Val Ser Tyr Cys Asp Glu 
    130                 135                 140                 


Cys Leu Lys Ala Thr His Pro Asn Lys Lys Pro Phe Thr Gly His Arg 
145                 150                 155                 160 


Leu Ile Glu Pro Ile Pro Asp Ser His Ile Arg Gly Leu Met Cys Leu 
                165                 170                 175     


Glu His Glu Asp Glu Lys Val Asn Met Tyr Cys Val Thr Asp Asp Gln 
            180                 185                 190         


Leu Ile Cys Ala Leu Cys Lys Leu Val Gly Arg His Arg Asp His Gln 
        195                 200                 205             


Val Ala Ala Leu Ser Glu Arg Tyr Asp Lys Leu Lys Gln Asn Leu Glu 
    210                 215                 220                 


Ser Asn Leu Thr Asn Leu Ile Lys Arg Asn Thr Glu Leu Glu Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Leu Ile Gln Thr Cys Gln His Val Glu Val Asn Ala Ser 
                245                 250                 255     


Arg Gln Glu Ala Lys Leu Thr Glu Glu Cys Asp Leu Leu Ile Glu Ile 
            260                 265                 270         


Ile Gln Gln Arg Arg Gln Ile Ile Gly Thr Lys Ile Lys Glu Gly Lys 
        275                 280                 285             


Val Met Arg Leu Arg Lys Leu Ala Gln Gln Ile Ala Asn Cys Lys Gln 
    290                 295                 300                 


Cys Ile Glu Arg Ser Ala Ser Leu Ile Ser Gln Ala Glu His Ser Leu 
305                 310                 315                 320 


Lys Glu Asn Asp His Ala Arg Phe Leu Gln Thr Ala Lys Asn Ile Thr 
                325                 330                 335     


Glu Arg Val Ser Met Ala Thr Ala Ser Ser Gln Val Leu Ile Pro Glu 
            340                 345                 350         


Ile Asn Leu Asn Asp Thr Phe Asp Thr Phe Ala Leu Asp Phe Ser Arg 
        355                 360                 365             


Glu Lys Lys Leu Leu Glu Cys Leu Asp Tyr Leu Thr Ala Pro Asn Pro 
    370                 375                 380                 


Pro Thr Ile Arg Glu Glu Leu Cys Thr Ala Ser Tyr Asp Thr Ile Thr 
385                 390                 395                 400 


Val His Trp Thr Ser Asp Asp Glu Phe Ser Val Val Ser Tyr Glu Leu 
                405                 410                 415     


Gln Tyr Thr Ile Phe Thr Gly Gln Ala Asn Val Val Ser Leu Cys Asn 
            420                 425                 430         


Ser Ala Asp Ser Trp Met Ile Val Pro Asn Ile Lys Gln Asn His Tyr 
        435                 440                 445             


Thr Val His Gly Leu Gln Ser Gly Thr Lys Tyr Ile Phe Met Val Lys 
    450                 455                 460                 


Ala Ile Asn Gln Ala Gly Ser Arg Ser Ser Glu Pro Gly Lys Leu Lys 
465                 470                 475                 480 


Thr Asn Ser Gln Pro Phe Lys Leu Asp Pro Lys Ser Ala His Arg Lys 
                485                 490                 495     


Leu Lys Val Ser His Asp Asn Leu Thr Val Glu Arg Asp Glu Ser Ser 
            500                 505                 510         


Ser Lys Lys Ser His Thr Pro Glu Arg Phe Thr Ser Gln Gly Ser Tyr 
        515                 520                 525             


Gly Val Ala Gly Asn Val Phe Ile Asp Ser Gly Arg His Tyr Trp Glu 
    530                 535                 540                 


Val Val Ile Ser Gly Ser Thr Trp Tyr Ala Ile Gly Leu Ala Tyr Lys 
545                 550                 555                 560 


Ser Ala Pro Lys His Glu Trp Ile Gly Lys Asn Ser Ala Ser Trp Ala 
                565                 570                 575     


Leu Cys Arg Cys Asn Asn Asn Trp Val Val Arg His Asn Ser Lys Glu 
            580                 585                 590         


Ile Pro Ile Glu Pro Ala Pro His Leu Arg Arg Val Gly Ile Leu Leu 
        595                 600                 605             


Asp Tyr Asp Asn Gly Ser Ile Ala Phe Tyr Asp Ala Leu Asn Ser Ile 
    610                 615                 620                 


His Leu Tyr Thr Phe Asp Val Ala Phe Ala Gln Pro Val Cys Pro Thr 
625                 630                 635                 640 


Phe Thr Val Trp Asn Lys Cys Leu Thr Ile Ile Thr Gly Leu Pro Ile 
                645                 650                 655     


Pro Asp His Leu Asp Cys Thr Glu Gln Leu Pro 
            660                 665         


<210>  5482
<211>  793
<212>  PRT
<213>  Homo sapiens

<400>  5482

Met Gly Leu Pro Glu Pro Gly Pro Leu Arg Leu Leu Ala Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Gln Leu Gln His Leu Ala Ala Ala 
            20                  25                  30          


Ala Ala Asp Pro Leu Leu Gly Gly Gln Gly Pro Ala Lys Asp Cys Glu 
        35                  40                  45              


Lys Asp Gln Phe Gln Cys Arg Asn Glu Arg Cys Ile Pro Ser Val Trp 
    50                  55                  60                  


Arg Cys Asp Glu Asp Asp Asp Cys Leu Asp His Ser Asp Glu Asp Asp 
65                  70                  75                  80  


Cys Pro Lys Lys Thr Cys Ala Asp Ser Asp Phe Thr Cys Asp Asn Gly 
                85                  90                  95      


His Cys Ile His Glu Arg Trp Lys Cys Asp Gly Glu Glu Glu Cys Pro 
            100                 105                 110         


Asp Gly Ser Asp Glu Ser Glu Ala Thr Cys Thr Lys Gln Val Cys Pro 
        115                 120                 125             


Ala Glu Lys Leu Ser Cys Gly Pro Thr Ser His Lys Cys Val Pro Ala 
    130                 135                 140                 


Ser Trp Arg Cys Asp Gly Glu Lys Asp Cys Glu Gly Gly Ala Asp Glu 
145                 150                 155                 160 


Ala Gly Cys Ala Thr Trp Leu Asn Glu Cys Leu His Asn Asn Gly Gly 
                165                 170                 175     


Cys Ser His Ile Cys Thr Asp Leu Lys Ile Gly Phe Glu Cys Thr Cys 
            180                 185                 190         


Pro Ala Gly Phe Gln Leu Leu Asp Gln Lys Thr Cys Gly Asp Ile Asp 
        195                 200                 205             


Glu Cys Lys Asp Pro Asp Ala Cys Ser Gln Ile Cys Val Asn Tyr Lys 
    210                 215                 220                 


Gly Tyr Phe Lys Cys Glu Cys Tyr Pro Gly Tyr Glu Met Asp Leu Leu 
225                 230                 235                 240 


Thr Lys Asn Cys Lys Ala Ala Ala Gly Lys Ser Pro Ser Leu Ile Phe 
                245                 250                 255     


Thr Asn Arg His Glu Val Arg Arg Ile Asp Leu Val Lys Arg Asn Tyr 
            260                 265                 270         


Ser Arg Leu Ile Pro Met Leu Lys Asn Val Val Ala Leu Asp Val Glu 
        275                 280                 285             


Val Ala Thr Asn Arg Ile Tyr Trp Cys Asp Leu Ser Tyr Arg Lys Ile 
    290                 295                 300                 


Tyr Ser Ala Tyr Met Asp Lys Ala Ser Asp Pro Lys Glu Gln Glu Val 
305                 310                 315                 320 


Leu Ile Asp Glu Gln Leu His Ser Pro Glu Gly Leu Ala Val Asp Trp 
                325                 330                 335     


Val His Lys His Ile Tyr Trp Thr Asp Ser Gly Asn Lys Thr Ile Ser 
            340                 345                 350         


Val Ala Thr Val Asp Gly Gly Arg Arg Arg Thr Leu Phe Ser Arg Asn 
        355                 360                 365             


Leu Ser Glu Pro Arg Ala Ile Ala Val Asp Pro Leu Arg Gly Phe Met 
    370                 375                 380                 


Tyr Trp Ser Asp Trp Gly Asp Gln Ala Lys Ile Glu Lys Ser Gly Leu 
385                 390                 395                 400 


Asn Gly Val Asp Arg Gln Thr Leu Val Ser Asp Asn Ile Glu Trp Pro 
                405                 410                 415     


Asn Gly Ile Thr Leu Asp Leu Leu Ser Gln Arg Leu Tyr Trp Val Asp 
            420                 425                 430         


Ser Lys Leu His Gln Leu Ser Ser Ile Asp Phe Ser Gly Gly Asn Arg 
        435                 440                 445             


Lys Thr Leu Ile Ser Ser Thr Asp Phe Leu Ser His Pro Phe Gly Ile 
    450                 455                 460                 


Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Leu Glu Asn Glu Ala 
465                 470                 475                 480 


Ile Phe Ser Ala Asn Arg Leu Asn Gly Leu Glu Ile Ser Ile Leu Ala 
                485                 490                 495     


Glu Asn Leu Asn Asn Pro His Asp Ile Val Ile Phe His Glu Leu Lys 
            500                 505                 510         


Gln Pro Arg Ala Pro Asp Ala Cys Glu Leu Ser Val Gln Pro Asn Gly 
        515                 520                 525             


Gly Cys Glu Tyr Leu Cys Leu Pro Ala Pro Gln Ile Ser Ser His Ser 
    530                 535                 540                 


Pro Lys Tyr Thr Cys Ala Cys Pro Asp Thr Met Trp Leu Gly Pro Asp 
545                 550                 555                 560 


Met Lys Arg Cys Tyr Arg Ala Pro Gln Ser Thr Ser Thr Thr Thr Leu 
                565                 570                 575     


Ala Ser Thr Met Thr Arg Thr Val Pro Ala Thr Thr Arg Ala Pro Gly 
            580                 585                 590         


Thr Thr Val His Arg Ser Thr Tyr Gln Asn His Ser Thr Glu Thr Pro 
        595                 600                 605             


Ser Leu Thr Ala Ala Val Pro Ser Ser Val Ser Val Pro Arg Ala Pro 
    610                 615                 620                 


Ser Ile Ser Pro Ser Thr Leu Ser Pro Ala Thr Ser Asn His Ser Gln 
625                 630                 635                 640 


His Tyr Ala Asn Glu Asp Ser Lys Met Gly Ser Thr Val Thr Ala Ala 
                645                 650                 655     


Val Ile Gly Ile Ile Val Pro Ile Val Val Ile Ala Leu Leu Cys Met 
            660                 665                 670         


Ser Gly Tyr Leu Ile Trp Arg Asn Trp Lys Arg Lys Asn Thr Lys Ser 
        675                 680                 685             


Met Asn Phe Asp Asn Pro Val Tyr Arg Lys Thr Thr Glu Glu Glu Asp 
    690                 695                 700                 


Glu Asp Glu Leu His Ile Gly Arg Thr Ala Gln Ile Gly His Val Tyr 
705                 710                 715                 720 


Pro Ala Ala Ile Ser Ser Phe Asp Arg Pro Leu Trp Ala Glu Pro Cys 
                725                 730                 735     


Leu Gly Glu Thr Arg Glu Pro Glu Asp Pro Ala Pro Ala Leu Lys Glu 
            740                 745                 750         


Leu Phe Val Leu Pro Gly Glu Pro Arg Ser Gln Leu His Gln Leu Pro 
        755                 760                 765             


Lys Asn Pro Leu Ser Glu Leu Pro Val Val Lys Ser Lys Arg Val Ala 
    770                 775                 780                 


Leu Ser Leu Glu Asp Asp Gly Leu Pro 
785                 790             


<210>  5483
<211>  429
<212>  PRT
<213>  Homo sapiens

<400>  5483

Met Val Phe Leu Ser Gly Asn Ala Ser Asp Ser Ser Asn Cys Thr Gln 
1               5                   10                  15      


Pro Pro Ala Pro Val Asn Ile Ser Lys Ala Ile Leu Leu Gly Val Ile 
            20                  25                  30          


Leu Gly Gly Leu Ile Leu Phe Gly Val Leu Gly Asn Ile Leu Val Ile 
        35                  40                  45              


Leu Ser Val Ala Cys His Arg His Leu His Ser Val Thr His Tyr Tyr 
    50                  55                  60                  


Ile Val Asn Leu Ala Val Ala Asp Leu Leu Leu Thr Ser Thr Val Leu 
65                  70                  75                  80  


Pro Phe Ser Ala Ile Phe Glu Val Leu Gly Tyr Trp Ala Phe Gly Arg 
                85                  90                  95      


Val Phe Cys Asn Ile Trp Ala Ala Val Asp Val Leu Cys Cys Thr Ala 
            100                 105                 110         


Ser Ile Met Gly Leu Cys Ile Ile Ser Ile Asp Arg Tyr Ile Gly Val 
        115                 120                 125             


Ser Tyr Pro Leu Arg Tyr Pro Thr Ile Val Thr Gln Arg Arg Gly Leu 
    130                 135                 140                 


Met Ala Leu Leu Cys Val Trp Ala Leu Ser Leu Val Ile Ser Ile Gly 
145                 150                 155                 160 


Pro Leu Phe Gly Trp Arg Gln Pro Ala Pro Glu Asp Glu Thr Ile Cys 
                165                 170                 175     


Gln Ile Asn Glu Glu Pro Gly Tyr Val Leu Phe Ser Ala Leu Gly Ser 
            180                 185                 190         


Phe Tyr Leu Pro Leu Ala Ile Ile Leu Val Met Tyr Cys Arg Val Tyr 
        195                 200                 205             


Val Val Ala Lys Arg Glu Ser Arg Gly Leu Lys Ser Gly Leu Lys Thr 
    210                 215                 220                 


Asp Lys Ser Asp Ser Glu Gln Val Thr Leu Arg Ile His Arg Lys Asn 
225                 230                 235                 240 


Ala Pro Ala Gly Gly Ser Gly Met Ala Ser Ala Lys Thr Lys Thr His 
                245                 250                 255     


Phe Ser Val Arg Leu Leu Lys Phe Ser Arg Glu Lys Lys Ala Ala Lys 
            260                 265                 270         


Thr Leu Gly Ile Val Val Gly Cys Phe Val Leu Cys Trp Leu Pro Phe 
        275                 280                 285             


Phe Leu Val Met Pro Ile Gly Ser Phe Phe Pro Asp Phe Lys Pro Ser 
    290                 295                 300                 


Glu Thr Val Phe Lys Ile Val Phe Trp Leu Gly Tyr Leu Asn Ser Cys 
305                 310                 315                 320 


Ile Asn Pro Ile Ile Tyr Pro Cys Ser Ser Gln Glu Phe Lys Lys Ala 
                325                 330                 335     


Phe Gln Asn Val Leu Arg Ile Gln Cys Leu Cys Arg Lys Gln Ser Ser 
            340                 345                 350         


Lys His Ala Leu Gly Tyr Thr Leu His Pro Pro Ser Gln Ala Val Glu 
        355                 360                 365             


Gly Gln His Lys Asp Met Val Arg Ile Pro Val Gly Ser Arg Glu Thr 
    370                 375                 380                 


Phe Tyr Arg Ile Ser Lys Thr Asp Gly Val Cys Glu Trp Lys Phe Phe 
385                 390                 395                 400 


Ser Ser Met Pro Arg Gly Ser Ala Arg Ile Thr Val Ser Lys Asp Gln 
                405                 410                 415     


Ser Ser Cys Thr Thr Ala Arg Gly His Thr Pro Met Thr 
            420                 425                 


<210>  5484
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  5484

Met Val Phe Leu Ser Gly Asn Ala Ser Asp Ser Ser Asn Cys Thr Gln 
1               5                   10                  15      


Pro Pro Ala Pro Val Asn Ile Ser Lys Ala Ile Leu Leu Gly Val Ile 
            20                  25                  30          


Leu Gly Gly Leu Ile Leu Phe Gly Val Leu Gly Asn Ile Leu Val Ile 
        35                  40                  45              


Leu Ser Val Ala Cys His Arg His Leu His Ser Val Thr His Tyr Tyr 
    50                  55                  60                  


Ile Val Asn Leu Ala Val Ala Asp Leu Leu Leu Thr Ser Thr Val Leu 
65                  70                  75                  80  


Pro Phe Ser Ala Ile Phe Glu Val Leu Gly Tyr Trp Ala Phe Gly Arg 
                85                  90                  95      


Val Phe Cys Asn Ile Trp Ala Ala Val Asp Val Leu Cys Cys Thr Ala 
            100                 105                 110         


Ser Ile Met Gly Leu Cys Ile Ile Ser Ile Asp Arg Tyr Ile Gly Val 
        115                 120                 125             


Ser Tyr Pro Leu Arg Tyr Pro Thr Ile Val Thr Gln Arg Arg Gly Leu 
    130                 135                 140                 


Met Ala Leu Leu Cys Val Trp Ala Leu Ser Leu Val Ile Ser Ile Gly 
145                 150                 155                 160 


Pro Leu Phe Gly Trp Arg Gln Pro Ala Pro Glu Asp Glu Thr Ile Cys 
                165                 170                 175     


Gln Ile Asn Glu Glu Pro Gly Tyr Val Leu Phe Ser Ala Leu Gly Ser 
            180                 185                 190         


Phe Tyr Leu Pro Leu Ala Ile Ile Leu Val Met Tyr Cys Arg Val Tyr 
        195                 200                 205             


Val Val Ala Lys Arg Glu Ser Arg Gly Leu Lys Ser Gly Leu Lys Thr 
    210                 215                 220                 


Asp Lys Ser Asp Ser Glu Gln Val Thr Leu Arg Ile His Arg Lys Asn 
225                 230                 235                 240 


Ala Pro Ala Gly Gly Ser Gly Met Ala Ser Ala Lys Thr Lys Thr His 
                245                 250                 255     


Phe Ser Val Arg Leu Leu Lys Phe Ser Arg Glu Lys Lys Ala Ala Lys 
            260                 265                 270         


Thr Leu Gly Ile Val Val Gly Cys Phe Val Leu Cys Trp Leu Pro Phe 
        275                 280                 285             


Phe Leu Val Met Pro Ile Gly Ser Phe Phe Pro Asp Phe Lys Pro Ser 
    290                 295                 300                 


Glu Thr Val Phe Lys Ile Val Phe Trp Leu Gly Tyr Leu Asn Ser Cys 
305                 310                 315                 320 


Ile Asn Pro Ile Ile Tyr Pro Cys Ser Ser Gln Glu Phe Lys Lys Ala 
                325                 330                 335     


Phe Gln Asn Val Leu Arg Ile Gln Cys Leu Cys Arg Lys Gln Ser Ser 
            340                 345                 350         


Lys His Ala Leu Gly Tyr Thr Leu His Pro Pro Ser Gln Ala Val Glu 
        355                 360                 365             


Gly Gln His Lys Asp Met Val Arg Ile Pro Val Gly Ser Arg Glu Thr 
    370                 375                 380                 


Phe Tyr Arg Ile Ser Lys Thr Asp Gly Val Cys Glu Trp Lys Phe Phe 
385                 390                 395                 400 


Ser Ser Met Pro Arg Gly Ser Ala Arg Ile Thr Val Ser Lys Asp Gln 
                405                 410                 415     


Ser Ser Cys Thr Thr Ala Arg Thr Lys Ser Arg Ser Val Thr Arg Leu 
            420                 425                 430         


Glu Cys Ser Gly Met Ile Leu Ala His Cys Asn Leu Arg Leu Pro Gly 
        435                 440                 445             


Ser Arg Asp Ser Pro Ala Ser Ala Ser Gln Ala Ala Gly Thr Thr Gly 
    450                 455                 460                 


Met Cys His Gln Ala Asp Ala Thr Arg Pro Ser 
465                 470                 475 


<210>  5485
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  5485

Met Val Phe Leu Ser Gly Asn Ala Ser Asp Ser Ser Asn Cys Thr Gln 
1               5                   10                  15      


Pro Pro Ala Pro Val Asn Ile Ser Lys Ala Ile Leu Leu Gly Val Ile 
            20                  25                  30          


Leu Gly Gly Leu Ile Leu Phe Gly Val Leu Gly Asn Ile Leu Val Ile 
        35                  40                  45              


Leu Ser Val Ala Cys His Arg His Leu His Ser Val Thr His Tyr Tyr 
    50                  55                  60                  


Ile Val Asn Leu Ala Val Ala Asp Leu Leu Leu Thr Ser Thr Val Leu 
65                  70                  75                  80  


Pro Phe Ser Ala Ile Phe Glu Val Leu Gly Tyr Trp Ala Phe Gly Arg 
                85                  90                  95      


Val Phe Cys Asn Ile Trp Ala Ala Val Asp Val Leu Cys Cys Thr Ala 
            100                 105                 110         


Ser Ile Met Gly Leu Cys Ile Ile Ser Ile Asp Arg Tyr Ile Gly Val 
        115                 120                 125             


Ser Tyr Pro Leu Arg Tyr Pro Thr Ile Val Thr Gln Arg Arg Gly Leu 
    130                 135                 140                 


Met Ala Leu Leu Cys Val Trp Ala Leu Ser Leu Val Ile Ser Ile Gly 
145                 150                 155                 160 


Pro Leu Phe Gly Trp Arg Gln Pro Ala Pro Glu Asp Glu Thr Ile Cys 
                165                 170                 175     


Gln Ile Asn Glu Glu Pro Gly Tyr Val Leu Phe Ser Ala Leu Gly Ser 
            180                 185                 190         


Phe Tyr Leu Pro Leu Ala Ile Ile Leu Val Met Tyr Cys Arg Val Tyr 
        195                 200                 205             


Val Val Ala Lys Arg Glu Ser Arg Gly Leu Lys Ser Gly Leu Lys Thr 
    210                 215                 220                 


Asp Lys Ser Asp Ser Glu Gln Val Thr Leu Arg Ile His Arg Lys Asn 
225                 230                 235                 240 


Ala Pro Ala Gly Gly Ser Gly Met Ala Ser Ala Lys Thr Lys Thr His 
                245                 250                 255     


Phe Ser Val Arg Leu Leu Lys Phe Ser Arg Glu Lys Lys Ala Ala Lys 
            260                 265                 270         


Thr Leu Gly Ile Val Val Gly Cys Phe Val Leu Cys Trp Leu Pro Phe 
        275                 280                 285             


Phe Leu Val Met Pro Ile Gly Ser Phe Phe Pro Asp Phe Lys Pro Ser 
    290                 295                 300                 


Glu Thr Val Phe Lys Ile Val Phe Trp Leu Gly Tyr Leu Asn Ser Cys 
305                 310                 315                 320 


Ile Asn Pro Ile Ile Tyr Pro Cys Ser Ser Gln Glu Phe Lys Lys Ala 
                325                 330                 335     


Phe Gln Asn Val Leu Arg Ile Gln Cys Leu Cys Arg Lys Gln Ser Ser 
            340                 345                 350         


Lys His Ala Leu Gly Tyr Thr Leu His Pro Pro Ser Gln Ala Val Glu 
        355                 360                 365             


Gly Gln His Lys Asp Met Val Arg Ile Pro Val Gly Ser Arg Glu Thr 
    370                 375                 380                 


Phe Tyr Arg Ile Ser Lys Thr Asp Gly Val Cys Glu Trp Lys Phe Phe 
385                 390                 395                 400 


Ser Ser Met Pro Arg Gly Ser Ala Arg Ile Thr Val Ser Lys Asp Gln 
                405                 410                 415     


Ser Ser Cys Thr Thr Ala Arg Arg Gly Met Asp Cys Arg Tyr Phe Thr 
            420                 425                 430         


Lys Asn Cys Arg Glu His Ile Lys His Val Asn Phe Met Met Pro Pro 
        435                 440                 445             


Trp Arg Lys Gly Ser Glu Cys 
    450                 455 


<210>  5486
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  5486

Met Arg Ser Thr Thr Leu Leu Ala Leu Leu Ala Leu Val Leu Leu Tyr 
1               5                   10                  15      


Leu Val Ser Gly Ala Leu Val Phe Arg Ala Leu Glu Gln Pro His Glu 
            20                  25                  30          


Gln Gln Ala Gln Arg Glu Leu Gly Glu Val Arg Glu Lys Phe Leu Arg 
        35                  40                  45              


Ala His Pro Cys Val Ser Asp Gln Glu Leu Gly Leu Leu Ile Lys Glu 
    50                  55                  60                  


Val Ala Asp Ala Leu Gly Gly Gly Ala Asp Pro Glu Thr Asn Ser Thr 
65                  70                  75                  80  


Ser Asn Ser Ser His Ser Ala Trp Asp Leu Gly Ser Ala Phe Phe Phe 
                85                  90                  95      


Ser Gly Thr Ile Ile Thr Thr Ile Gly Tyr Gly Asn Val Ala Leu Arg 
            100                 105                 110         


Thr Asp Ala Gly Arg Leu Phe Cys Ile Phe Tyr Ala Leu Val Gly Ile 
        115                 120                 125             


Pro Leu Phe Gly Ile Leu Leu Ala Gly Val Gly Asp Arg Leu Gly Ser 
    130                 135                 140                 


Ser Leu Arg His Gly Ile Gly His Ile Glu Ala Ile Phe Leu Lys Trp 
145                 150                 155                 160 


His Val Pro Pro Glu Leu Val Arg Val Leu Ser Ala Met Leu Phe Leu 
                165                 170                 175     


Leu Ile Gly Cys Leu Leu Phe Val Leu Thr Pro Thr Phe Val Phe Cys 
            180                 185                 190         


Tyr Met Glu Asp Trp Ser Lys Leu Glu Ala Ile Tyr Phe Val Ile Val 
        195                 200                 205             


Thr Leu Thr Thr Val Gly Phe Gly Asp Tyr Val Ala Gly Ala Asp Pro 
    210                 215                 220                 


Arg Gln Asp Ser Pro Ala Tyr Gln Pro Leu Val Trp Phe Trp Ile Leu 
225                 230                 235                 240 


Leu Gly Leu Ala Tyr Phe Ala Ser Val Leu Thr Thr Ile Gly Asn Trp 
                245                 250                 255     


Leu Arg Val Val Ser Arg Arg Thr Arg Ala Glu Met Gly Gly Leu Thr 
            260                 265                 270         


Ala Gln Ala Ala Ser Trp Thr Gly Thr Val Thr Ala Arg Val Thr Gln 
        275                 280                 285             


Arg Ala Gly Pro Ala Ala Pro Pro Pro Glu Lys Glu Gln Pro Leu Leu 
    290                 295                 300                 


Pro Pro Pro Pro Cys Pro Ala Gln Pro Leu Gly Arg Pro Arg Ser Pro 
305                 310                 315                 320 


Ser Pro Pro Glu Lys Ala Gln Pro Pro Ser Pro Pro Thr Ala Ser Ala 
                325                 330                 335     


Leu Asp Tyr Pro Ser Glu Asn Leu Ala Phe Ile Asp Glu Ser Ser Asp 
            340                 345                 350         


Thr Gln Ser Glu Arg Gly Cys Pro Leu Pro Arg Ala Pro Arg Gly Arg 
        355                 360                 365             


Arg Arg Pro Asn Pro Pro Arg Lys Pro Val Arg Pro Arg Gly Pro Gly 
    370                 375                 380                 


Arg Pro Arg Asp Lys Gly Val Pro Val 
385                 390             


<210>  5487
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  5487

Met Ala Ser Gly Ala Ala Arg Trp Leu Val Leu Ala Pro Val Arg Ser 
1               5                   10                  15      


Gly Ala Leu Arg Ser Gly Pro Ser Leu Arg Lys Asp Gly Asp Val Ser 
            20                  25                  30          


Ala Ala Trp Ser Gly Ser Gly Arg Ser Leu Val Pro Ser Arg Ser Val 
        35                  40                  45              


Ile Val Thr Arg Ser Gly Ala Ile Leu Pro Lys Pro Val Lys Met Ser 
    50                  55                  60                  


Phe Gly Leu Leu Arg Val Phe Ser Ile Val Ile Pro Phe Leu Tyr Val 
65                  70                  75                  80  


Gly Thr Leu Ile Ser Lys Asn Phe Ala Ala Leu Leu Glu Glu His Asp 
                85                  90                  95      


Ile Phe Val Pro Glu Asp Asp Asp Asp Asp Asp 
            100                 105         


<210>  5488
<211>  498
<212>  PRT
<213>  Homo sapiens

<400>  5488

Met Lys Arg Lys Ser Glu Arg Arg Ser Ser Trp Ala Ala Ala Pro Pro 
1               5                   10                  15      


Cys Ser Arg Arg Cys Ser Ser Thr Ser Pro Gly Val Lys Lys Ile Arg 
            20                  25                  30          


Ser Ser Thr Gln Gln Asp Pro Arg Arg Arg Asp Pro Gln Asp Asp Val 
        35                  40                  45              


Tyr Leu Asp Ile Thr Asp Arg Leu Cys Phe Ala Ile Leu Tyr Ser Arg 
    50                  55                  60                  


Pro Lys Ser Ala Ser Asn Val His Tyr Phe Ser Ile Asp Asn Glu Leu 
65                  70                  75                  80  


Glu Tyr Glu Asn Phe Tyr Ala Asp Phe Gly Pro Leu Asn Leu Ala Met 
                85                  90                  95      


Val Tyr Arg Tyr Cys Cys Lys Ile Asn Lys Lys Leu Lys Ser Ile Thr 
            100                 105                 110         


Met Leu Arg Lys Lys Ile Val His Phe Thr Gly Ser Asp Gln Arg Lys 
        115                 120                 125             


Gln Ala Asn Ala Ala Phe Leu Val Gly Cys Tyr Met Val Ile Tyr Leu 
    130                 135                 140                 


Gly Arg Thr Pro Glu Glu Ala Tyr Arg Ile Leu Ile Phe Gly Glu Thr 
145                 150                 155                 160 


Ser Tyr Ile Pro Phe Arg Asp Ala Ala Tyr Gly Ser Cys Asn Phe Tyr 
                165                 170                 175     


Ile Thr Leu Leu Asp Cys Phe His Ala Val Lys Lys Ala Met Gln Tyr 
            180                 185                 190         


Gly Phe Leu Asn Phe Asn Ser Phe Asn Leu Asp Glu Tyr Glu His Tyr 
        195                 200                 205             


Glu Lys Ala Glu Asn Gly Asp Leu Asn Trp Ile Ile Pro Asp Arg Phe 
    210                 215                 220                 


Ile Ala Phe Cys Gly Pro His Ser Arg Ala Arg Leu Glu Ser Gly Tyr 
225                 230                 235                 240 


His Gln His Ser Pro Glu Thr Tyr Ile Gln Tyr Phe Lys Asn His Asn 
                245                 250                 255     


Val Thr Thr Ile Ile Arg Leu Asn Lys Arg Met Tyr Asp Ala Lys Arg 
            260                 265                 270         


Phe Thr Asp Ala Gly Phe Asp His His Asp Leu Phe Phe Ala Asp Gly 
        275                 280                 285             


Ser Thr Pro Thr Asp Ala Ile Val Lys Glu Phe Leu Asp Ile Cys Glu 
    290                 295                 300                 


Asn Ala Glu Gly Ala Ile Ala Val His Cys Lys Ala Gly Leu Gly Arg 
305                 310                 315                 320 


Thr Gly Thr Leu Ile Ala Cys Tyr Ile Met Lys His Tyr Arg Met Thr 
                325                 330                 335     


Ala Ala Glu Thr Ile Ala Trp Val Arg Ile Cys Arg Pro Gly Ser Val 
            340                 345                 350         


Ile Gly Pro Gln Gln Gln Phe Leu Val Met Lys Gln Thr Asn Leu Trp 
        355                 360                 365             


Leu Glu Gly Asp Tyr Phe Arg Gln Lys Leu Lys Gly Gln Glu Asn Gly 
    370                 375                 380                 


Gln His Arg Ala Ala Phe Ser Lys Leu Leu Ser Gly Val Asp Asp Ile 
385                 390                 395                 400 


Ser Ile Asn Gly Val Glu Asn Gln Asp Gln Gln Glu Pro Glu Pro Tyr 
                405                 410                 415     


Ser Asp Asp Asp Glu Ile Asn Gly Val Thr Gln Gly Asp Arg Leu Arg 
            420                 425                 430         


Ala Leu Lys Ser Arg Arg Gln Ser Lys Thr Asn Ala Ile Pro Leu Thr 
        435                 440                 445             


Val Ile Leu Gln Ser Ser Val Gln Ser Cys Lys Thr Ser Glu Pro Asn 
    450                 455                 460                 


Ile Ser Gly Ser Ala Gly Ile Thr Lys Arg Thr Thr Arg Ser Ala Ser 
465                 470                 475                 480 


Arg Lys Ser Ser Val Lys Ser Leu Ser Ile Ser Arg Thr Lys Thr Val 
                485                 490                 495     


Leu Arg 
        


<210>  5489
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  5489

Met Met Ala Glu Glu His Thr Asp Leu Glu Ala Gln Ile Val Lys Asp 
1               5                   10                  15      


Ile His Cys Lys Glu Ile Asp Leu Val Asn Arg Asp Pro Lys Asn Ile 
            20                  25                  30          


Asn Glu Asp Ile Val Lys Val Asp Phe Glu Asp Val Ile Ala Glu Pro 
        35                  40                  45              


Val Gly Thr Tyr Ser Phe Asp Gly Val Trp Lys Val Ser Tyr Thr Thr 
    50                  55                  60                  


Phe Thr Val Ser Lys Tyr Trp Cys Tyr Arg Leu Leu Ser Thr Leu Leu 
65                  70                  75                  80  


Gly Val Pro Leu Ala Leu Leu Trp Gly Phe Leu Phe Ala Cys Ile Ser 
                85                  90                  95      


Phe Cys His Ile Trp Ala Val Val Pro Cys Ile Lys Ser Tyr Leu Ile 
            100                 105                 110         


Glu Ile Gln Cys Ile Ser His Ile Tyr Ser Leu Cys Ile Arg Thr Phe 
        115                 120                 125             


Cys Asn Pro Leu Phe Ala Ala Leu Gly Gln Val Cys Ser Ser Ile Lys 
    130                 135                 140                 


Val Val Leu Arg Lys Glu Val 
145                 150     


<210>  5490
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  5490

Met Gly Gly Leu Arg Pro Trp Ser Arg Tyr Gly Leu Leu Val Val Ala 
1               5                   10                  15      


His Leu Leu Ala Leu Gly Leu Gly Ala Val Val Phe Gln Ala Leu Glu 
            20                  25                  30          


Gly Pro Pro Ala Cys Arg Leu Gln Ala Glu Leu Arg Ala Glu Leu Ala 
        35                  40                  45              


Ala Phe Gln Ala Glu His Arg Ala Cys Leu Pro Pro Gly Ala Leu Glu 
    50                  55                  60                  


Glu Leu Leu Gly Thr Ala Leu Ala Thr Gln Ala His Gly Val Ser Thr 
65                  70                  75                  80  


Leu Gly Asn Ser Ser Glu Gly Arg Thr Trp Asp Leu Pro Ser Ala Leu 
                85                  90                  95      


Leu Phe Ala Ala Ser Ile Leu Thr Thr Thr Gly Tyr Gly His Met Ala 
            100                 105                 110         


Pro Leu Ser Pro Gly Gly Lys Ala Phe Cys Met Val Tyr Ala Ala Leu 
        115                 120                 125             


Gly Leu Pro Ala Ser Leu Ala Leu Val Ala Thr Leu Arg His Cys Leu 
    130                 135                 140                 


Leu Pro Val Leu Ser Arg Pro Arg Ala Trp Val Ala Val His Trp Gln 
145                 150                 155                 160 


Leu Ser Pro Ala Arg Ala Ala Leu Leu Gln Ala Val Ala Leu Gly Leu 
                165                 170                 175     


Leu Val Ala Ser Ser Phe Val Leu Leu Pro Ala Leu Val Leu Trp Gly 
            180                 185                 190         


Leu Gln Gly Asp Cys Ser Leu Leu Gly Ala Val Tyr Phe Cys Phe Ser 
        195                 200                 205             


Ser Leu Ser Thr Ile Gly Leu Glu Asp Leu Leu Pro Gly Arg Gly Arg 
    210                 215                 220                 


Ser Leu His Pro Val Ile Tyr His Leu Gly Gln Leu Ala Leu Leu Gly 
225                 230                 235                 240 


Tyr Leu Leu Leu Gly Leu Leu Ala Met Leu Leu Ala Val Glu Thr Phe 
                245                 250                 255     


Ser Glu Leu Pro Gln Val Arg Ala Met Gly Lys Phe Phe Arg Pro Ser 
            260                 265                 270         


Gly Pro Val Thr Ala Glu Asp Gln Gly Gly Ile Leu Gly Gln Asp Glu 
        275                 280                 285             


Leu Ala Leu Ser Thr Leu Pro Pro Ala Ala Pro Ala Ser Gly Gln Ala 
    290                 295                 300                 


Pro Ala Cys 
305         


<210>  5491
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  5491

Met Gly Gly Leu Arg Pro Trp Ser Arg Tyr Gly Leu Leu Val Val Ala 
1               5                   10                  15      


His Leu Leu Ala Leu Gly Leu Gly Ala Val Val Phe Gln Ala Leu Glu 
            20                  25                  30          


Gly Pro Pro Ala Cys Arg Leu Gln Ala Glu Leu Arg Ala Glu Leu Ala 
        35                  40                  45              


Ala Phe Gln Ala Glu His Arg Ala Cys Leu Pro Pro Gly Ala Leu Glu 
    50                  55                  60                  


Glu Leu Leu Gly Thr Ala Leu Ala Thr Gln Ala His Gly Val Ser Thr 
65                  70                  75                  80  


Leu Gly Asn Ser Ser Glu Gly Arg Thr Trp Asp Leu Pro Ser Ala Leu 
                85                  90                  95      


Leu Phe Ala Ala Ser Ile Leu Thr Thr Thr Gly Tyr Gly His Met Ala 
            100                 105                 110         


Pro Leu Ser Pro Gly Gly Lys Ala Phe Cys Met Val Tyr Ala Ala Leu 
        115                 120                 125             


Gly Leu Pro Ala Ser Leu Ala Leu Val Ala Thr Leu Arg His Cys Leu 
    130                 135                 140                 


Leu Pro Val Leu Ser Arg Pro Arg Ala Trp Val Ala Val His Trp Gln 
145                 150                 155                 160 


Leu Ser Pro Ala Arg Ala Ala Leu Leu Gln Ala Val Ala Leu Gly Leu 
                165                 170                 175     


Leu Val Ala Ser Ser Phe Val Leu Leu Pro Ala Leu Val Leu Trp Gly 
            180                 185                 190         


Leu Gln Gly Asp Cys Ser Leu Leu Gly Ala Val Tyr Phe Cys Phe Ser 
        195                 200                 205             


Ser Leu Ser Thr Ile Gly Leu Glu Asp Leu Leu Pro Gly Arg Gly Arg 
    210                 215                 220                 


Ser Leu His Pro Val Ile Tyr His Leu Gly Gln Leu Ala Leu Leu Gly 
225                 230                 235                 240 


Gly Gly Thr Ser Leu Gln Gly Thr Ala Trp Glu Gly 
                245                 250         


<210>  5492
<211>  1308
<212>  PRT
<213>  Homo sapiens

<400>  5492

Met Gly Ser Val Thr Gly Ala Val Leu Lys Thr Leu Leu Leu Leu Ser 
1               5                   10                  15      


Thr Gln Asn Trp Asn Arg Val Glu Ala Gly Asn Ser Tyr Asp Cys Asp 
            20                  25                  30          


Asp Pro Leu Val Ser Ala Leu Pro Gln Ala Ser Phe Ser Ser Ser Ser 
        35                  40                  45              


Glu Leu Ser Ser Ser His Gly Pro Gly Phe Ala Arg Leu Asn Arg Arg 
    50                  55                  60                  


Asp Gly Ala Gly Gly Trp Ser Pro Leu Val Ser Asn Lys Tyr Gln Trp 
65                  70                  75                  80  


Leu Gln Ile Asp Leu Gly Glu Arg Met Glu Val Thr Ala Val Ala Thr 
                85                  90                  95      


Gln Gly Gly Tyr Gly Ser Ser Asn Trp Val Thr Ser Tyr Leu Leu Met 
            100                 105                 110         


Phe Ser Asp Ser Gly Trp Asn Trp Lys Gln Tyr Arg Gln Glu Asp Ser 
        115                 120                 125             


Ile Trp Gly Phe Ser Gly Asn Ala Asn Ala Asp Ser Val Val Tyr Tyr 
    130                 135                 140                 


Arg Leu Gln Pro Ser Ile Lys Ala Arg Phe Leu Arg Phe Ile Pro Leu 
145                 150                 155                 160 


Glu Trp Asn Pro Lys Gly Arg Ile Gly Met Arg Ile Glu Val Phe Gly 
                165                 170                 175     


Cys Ala Tyr Arg Ser Glu Val Val Asp Leu Asp Gly Lys Ser Ser Leu 
            180                 185                 190         


Leu Tyr Arg Phe Asp Gln Lys Ser Leu Ser Pro Ile Lys Asp Ile Ile 
        195                 200                 205             


Ser Leu Lys Phe Lys Thr Met Gln Ser Asp Gly Ile Leu Leu His Arg 
    210                 215                 220                 


Glu Gly Pro Asn Gly Asp His Ile Thr Leu Gln Leu Arg Arg Ala Arg 
225                 230                 235                 240 


Leu Phe Leu Leu Ile Asn Ser Gly Glu Ala Lys Leu Pro Ser Thr Ser 
                245                 250                 255     


Thr Leu Val Asn Leu Thr Leu Gly Ser Leu Leu Asp Asp Gln His Trp 
            260                 265                 270         


His Ser Val Leu Ile Gln Arg Leu Gly Lys Gln Val Asn Phe Thr Val 
        275                 280                 285             


Asp Glu His Arg His His Phe His Ala Arg Gly Glu Phe Asn Leu Met 
    290                 295                 300                 


Asn Leu Asp Tyr Glu Ile Ser Phe Gly Gly Ile Pro Ala Pro Gly Lys 
305                 310                 315                 320 


Ser Val Ser Phe Pro His Arg Asn Phe His Gly Cys Leu Glu Asn Leu 
                325                 330                 335     


Tyr Tyr Asn Gly Val Asp Ile Ile Asp Leu Ala Lys Gln Gln Lys Pro 
            340                 345                 350         


Gln Ile Ile Ala Met Gly Asn Val Ser Phe Ser Cys Ser Gln Pro Gln 
        355                 360                 365             


Ser Met Pro Val Thr Phe Leu Ser Ser Arg Ser Tyr Leu Ala Leu Pro 
    370                 375                 380                 


Asp Phe Ser Gly Glu Glu Glu Val Ser Ala Thr Phe Gln Phe Arg Thr 
385                 390                 395                 400 


Trp Asn Lys Ala Gly Leu Leu Leu Phe Ser Glu Leu Gln Leu Ile Ser 
                405                 410                 415     


Gly Gly Ile Leu Leu Phe Leu Ser Asp Gly Lys Leu Lys Ser Asn Leu 
            420                 425                 430         


Tyr Gln Pro Gly Lys Leu Pro Ser Asp Ile Thr Ala Gly Val Glu Leu 
        435                 440                 445             


Asn Asp Gly Gln Trp His Ser Val Ser Leu Ser Ala Lys Lys Asn His 
    450                 455                 460                 


Leu Ser Val Ala Val Asp Gly Gln Met Ala Ser Ala Ala Pro Leu Leu 
465                 470                 475                 480 


Gly Pro Glu Gln Ile Tyr Ser Gly Gly Thr Tyr Tyr Phe Gly Gly Cys 
                485                 490                 495     


Pro Asp Lys Ser Phe Gly Ser Lys Cys Lys Ser Pro Leu Gly Gly Phe 
            500                 505                 510         


Gln Gly Cys Met Arg Leu Ile Ser Ile Ser Gly Lys Val Val Asp Leu 
        515                 520                 525             


Ile Ser Val Gln Gln Gly Ser Leu Gly Asn Phe Ser Asp Leu Gln Ile 
    530                 535                 540                 


Asp Ser Cys Gly Ile Ser Asp Arg Cys Leu Pro Asn Tyr Cys Glu His 
545                 550                 555                 560 


Gly Gly Glu Cys Ser Gln Ser Trp Ser Thr Phe His Cys Asn Cys Thr 
                565                 570                 575     


Asn Thr Gly Tyr Arg Gly Ala Thr Cys His Asn Ser Ile Tyr Glu Gln 
            580                 585                 590         


Ser Cys Glu Ala Tyr Lys His Arg Gly Asn Thr Ser Gly Phe Tyr Tyr 
        595                 600                 605             


Ile Asp Ser Asp Gly Ser Gly Pro Leu Glu Pro Phe Leu Leu Tyr Cys 
    610                 615                 620                 


Asn Met Thr Glu Thr Ala Trp Thr Ile Ile Gln His Asn Gly Ser Asp 
625                 630                 635                 640 


Leu Thr Arg Val Arg Asn Thr Asn Pro Glu Asn Pro Tyr Ala Gly Phe 
                645                 650                 655     


Phe Glu Tyr Val Ala Ser Met Glu Gln Leu Gln Ala Thr Ile Asn Arg 
            660                 665                 670         


Ala Glu His Cys Glu Gln Glu Phe Thr Tyr Tyr Cys Lys Lys Ser Arg 
        675                 680                 685             


Leu Val Asn Lys Gln Asp Gly Thr Pro Leu Ser Trp Trp Val Gly Arg 
    690                 695                 700                 


Thr Asn Glu Thr Gln Thr Tyr Trp Gly Gly Ser Ser Pro Asp Leu Gln 
705                 710                 715                 720 


Lys Cys Thr Cys Gly Leu Glu Gly Asn Cys Ile Asp Ser Gln Tyr Tyr 
                725                 730                 735     


Cys Asn Cys Asp Ala Asp Arg Asn Glu Trp Thr Asn Asp Thr Gly Leu 
            740                 745                 750         


Leu Ala Tyr Lys Glu His Leu Pro Val Thr Lys Ile Val Ile Thr Asp 
        755                 760                 765             


Thr Gly Arg Leu His Ser Glu Ala Ala Tyr Lys Leu Gly Pro Leu Leu 
    770                 775                 780                 


Cys Gln Gly Asp Arg Ser Phe Trp Asn Ser Ala Ser Phe Asp Thr Glu 
785                 790                 795                 800 


Ala Ser Tyr Leu His Phe Pro Thr Phe His Gly Glu Leu Ser Ala Asp 
                805                 810                 815     


Val Ser Phe Phe Phe Lys Thr Thr Ala Ser Ser Gly Val Phe Leu Glu 
            820                 825                 830         


Asn Leu Gly Ile Ala Asp Phe Ile Arg Ile Glu Leu Arg Ser Pro Thr 
        835                 840                 845             


Val Val Thr Phe Ser Phe Asp Val Gly Asn Gly Pro Phe Glu Ile Ser 
    850                 855                 860                 


Val Gln Ser Pro Thr His Phe Asn Asp Asn Gln Trp His His Val Arg 
865                 870                 875                 880 


Val Glu Arg Asn Met Lys Glu Ala Ser Leu Gln Val Asp Gln Leu Thr 
                885                 890                 895     


Pro Lys Thr Gln Pro Ala Pro Ala Asp Gly His Val Leu Leu Gln Leu 
            900                 905                 910         


Asn Ser Gln Leu Phe Val Gly Gly Thr Ala Thr Arg Gln Arg Gly Phe 
        915                 920                 925             


Leu Gly Cys Ile Arg Ser Leu Gln Leu Asn Gly Met Thr Leu Asp Leu 
    930                 935                 940                 


Glu Glu Arg Ala Gln Val Thr Pro Glu Val Gln Pro Gly Cys Arg Gly 
945                 950                 955                 960 


His Cys Ser Ser Tyr Gly Lys Leu Cys Arg Asn Gly Gly Lys Cys Arg 
                965                 970                 975     


Glu Arg Pro Ile Gly Phe Phe Cys Asp Cys Thr Phe Ser Ala Tyr Thr 
            980                 985                 990         


Gly Pro Phe Cys Ser Asn Glu Ile  Ser Ala Tyr Phe Gly  Ser Gly Ser 
        995                 1000                 1005             


Ser Val  Ile Tyr Asn Phe Gln  Glu Asn Tyr Leu Leu  Ser Lys Asn 
    1010                 1015                 1020             


Ser Ser  Ser His Ala Ala Ser  Phe His Gly Asp Met  Lys Leu Ser 
    1025                 1030                 1035             


Arg Glu  Met Ile Lys Phe Ser  Phe Arg Thr Thr Arg  Thr Pro Ser 
    1040                 1045                 1050             


Leu Leu  Leu Phe Val Ser Ser  Phe Tyr Lys Glu Tyr  Leu Ser Val 
    1055                 1060                 1065             


Ile Ile  Ala Lys Asn Gly Ser  Leu Gln Ile Arg Tyr  Lys Leu Asn 
    1070                 1075                 1080             


Lys Tyr  Gln Glu Pro Asp Val  Val Asn Phe Asp Phe  Lys Asn Met 
    1085                 1090                 1095             


Ala Asp  Gly Gln Leu His His  Ile Met Ile Asn Arg  Glu Glu Gly 
    1100                 1105                 1110             


Val Val  Phe Ile Glu Ile Asp  Asp Asn Arg Arg Arg  Gln Val His 
    1115                 1120                 1125             


Leu Ser  Ser Gly Thr Glu Phe  Ser Ala Val Lys Ser  Leu Val Leu 
    1130                 1135                 1140             


Gly Arg  Ile Leu Glu His Ser  Asp Val Asp Gln Asp  Thr Ala Leu 
    1145                 1150                 1155             


Ala Gly  Ala Gln Gly Phe Thr  Gly Cys Leu Ser Ala  Val Gln Leu 
    1160                 1165                 1170             


Ser His  Val Ala Pro Leu Lys  Ala Ala Leu His Pro  Ser His Pro 
    1175                 1180                 1185             


Asp Pro  Val Thr Val Thr Gly  His Val Thr Glu Ser  Ser Cys Met 
    1190                 1195                 1200             


Ala Gln  Pro Gly Thr Asp Ala  Thr Ser Arg Glu Arg  Thr His Ser 
    1205                 1210                 1215             


Phe Ala  Asp His Ser Gly Thr  Ile Asp Asp Arg Glu  Pro Leu Ala 
    1220                 1225                 1230             


Asn Ala  Ile Lys Ser Asp Ser  Ala Val Ile Gly Gly  Leu Ile Ala 
    1235                 1240                 1245             


Val Val  Ile Phe Ile Leu Leu  Cys Ile Thr Ala Ile  Ala Val Arg 
    1250                 1255                 1260             


Ile Tyr  Gln Gln Lys Arg Leu  Tyr Lys Arg Ser Glu  Ala Lys Arg 
    1265                 1270                 1275             


Ser Glu  Asn Val Asp Ser Ala  Glu Ala Val Leu Lys  Ser Glu Leu 
    1280                 1285                 1290             


Asn Ile  Gln Asn Ala Val Asn  Glu Asn Gln Lys Glu  Tyr Phe Phe 
    1295                 1300                 1305             


<210>  5493
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  5493

Met Glu Glu Gly Gly Asn Leu Gly Gly Leu Ile Lys Met Val His Leu 
1               5                   10                  15      


Leu Val Leu Ser Gly Ala Trp Gly Met Gln Met Trp Val Thr Phe Val 
            20                  25                  30          


Ser Gly Phe Leu Leu Phe Arg Ser Leu Pro Arg His Thr Phe Gly Leu 
        35                  40                  45              


Val Gln Ser Lys Leu Phe Pro Phe Tyr Phe His Ile Ser Met Gly Cys 
    50                  55                  60                  


Ala Phe Ile Asn Leu Cys Ile Leu Ala Ser Gln His Ala Trp Ala Gln 
65                  70                  75                  80  


Leu Thr Phe Trp Glu Ala Ser Gln Leu Tyr Leu Leu Phe Leu Ser Leu 
                85                  90                  95      


Thr Leu Ala Thr Val Asn Ala Arg Trp Leu Glu Pro Arg Thr Thr Ala 
            100                 105                 110         


Ala Met Trp Ala Leu Gln Thr Val Glu Lys Glu Arg Gly Leu Gly Gly 
        115                 120                 125             


Glu Val Pro Gly Ser His Gln Gly Pro Asp Pro Tyr Arg Gln Leu Arg 
    130                 135                 140                 


Glu Lys Asp Pro Lys Tyr Ser Ala Leu Arg Gln Asn Phe Phe Arg Tyr 
145                 150                 155                 160 


His Gly Leu Ser Ser Leu Cys Asn Leu Gly Cys Val Leu Ser Asn Gly 
                165                 170                 175     


Leu Cys Leu Ala Gly Leu Ala Leu Glu Ile Arg Ser Leu 
            180                 185                 


<210>  5494
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  5494

Met Ala Phe Leu Met His Leu Leu Val Cys Val Phe Gly Met Gly Ser 
1               5                   10                  15      


Trp Val Thr Ile Asn Gly Leu Trp Val Glu Leu Pro Leu Leu Val Met 
            20                  25                  30          


Glu Leu Pro Glu Gly Trp Tyr Leu Pro Ser Tyr Leu Thr Val Val Ile 
        35                  40                  45              


Gln Leu Ala Asn Ile Gly Pro Leu Leu Val Thr Leu Leu His His Phe 
    50                  55                  60                  


Arg Pro Ser Cys Leu Ser Glu Val Pro Ile Ile Phe Thr Leu Leu Gly 
65                  70                  75                  80  


Val Gly Thr Val Thr Cys Ile Ile Phe Ala Phe Leu Trp Asn Met Thr 
                85                  90                  95      


Ser Trp Val Leu Asp Gly His His Ser Ile Ala Phe Leu Val Leu Thr 
            100                 105                 110         


Phe Phe Leu Ala Leu Val Asp Cys Thr Ser Ser Val Thr Phe Leu Pro 
        115                 120                 125             


Phe Met Ser Arg Leu Pro Thr Tyr Tyr Leu Thr Thr Phe Phe Val Gly 
    130                 135                 140                 


Glu Gly Leu Ser Gly Leu Leu Pro Ala Leu Val Ala Leu Ala Gln Gly 
145                 150                 155                 160 


Ser Gly Leu Thr Thr Cys Val Asn Val Thr Glu Ile Ser Asp Ser Val 
                165                 170                 175     


Pro Ser Pro Val Pro Thr Arg Glu Thr Asp Ile Ala Gln Gly Val Pro 
            180                 185                 190         


Arg Ala Leu Val Ser Ala Leu Pro Gly Met Glu Ala Pro Leu Ser His 
        195                 200                 205             


Leu Glu Ser Arg Tyr Leu Pro Ala His Phe Ser Pro Leu Val Phe Phe 
    210                 215                 220                 


Leu Leu Leu Ser Ile Met Met Ala Cys Cys Leu Val Ala Phe Phe Val 
225                 230                 235                 240 


Leu Gln Arg Gln Pro Arg Cys Trp Glu Ala Ser Val Glu Asp Leu Leu 
                245                 250                 255     


Asn Asp Gln Val Thr Leu His Ser Ile Arg Pro Arg Glu Glu Asn Asp 
            260                 265                 270         


Leu Gly Pro Ala Gly Thr Val Asp Ser Ser Gln Gly Gln Gly Tyr Leu 
        275                 280                 285             


Glu Glu Lys Ala Ala Pro Cys Cys Pro Ala His Leu Ala Phe Ile Tyr 
    290                 295                 300                 


Thr Leu Val Ala Phe Val Asn Ala Leu Thr Asn Gly Met Leu Pro Ser 
305                 310                 315                 320 


Val Gln Thr Tyr Ser Cys Leu Ser Tyr Gly Pro Val Ala Tyr His Leu 
                325                 330                 335     


Ala Ala Thr Leu Ser Ile Val Ala Asn Pro Leu Ala Ser Leu Val Ser 
            340                 345                 350         


Met Phe Leu Pro Asn Arg Ser Leu Leu Phe Leu Gly Val Leu Ser Val 
        355                 360                 365             


Leu Gly Thr Cys Phe Gly Gly Tyr Asn Met Ala Met Ala Val Met Ser 
    370                 375                 380                 


Pro Cys Pro Leu Leu Gln Gly His Trp Gly Gly Glu Val Leu Ile Val 
385                 390                 395                 400 


Ala Ser Trp Val Leu Phe Ser Gly Cys Leu Ser Tyr Val Lys Val Met 
                405                 410                 415     


Leu Gly Val Val Leu Arg Asp Leu Ser Arg Ser Ala Leu Leu Trp Cys 
            420                 425                 430         


Gly Ala Ala Val Gln Leu Gly Ser Leu Leu Gly Ala Leu Leu Met Phe 
        435                 440                 445             


Pro Leu Val Asn Val Leu Arg Leu Phe Ser Ser Ala Asp Phe Cys Asn 
    450                 455                 460                 


Leu His Cys Pro Ala 
465                 


<210>  5495
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  5495

Met Ala Gly Leu Ala Ala Arg Leu Val Leu Leu Ala Gly Ala Ala Ala 
1               5                   10                  15      


Leu Ala Ser Gly Ser Gln Gly Asp Arg Glu Pro Val Tyr Arg Asp Cys 
            20                  25                  30          


Val Leu Gln Cys Glu Glu Gln Asn Cys Ser Gly Gly Ala Leu Asn His 
        35                  40                  45              


Phe Arg Ser Arg Gln Pro Ile Tyr Met Ser Leu Ala Gly Trp Thr Cys 
    50                  55                  60                  


Arg Asp Asp Cys Lys Tyr Glu Cys Met Trp Val Thr Val Gly Leu Tyr 
65                  70                  75                  80  


Leu Gln Glu Gly His Lys Val Pro Gln Phe His Gly Lys Trp Pro Phe 
                85                  90                  95      


Ser Arg Phe Leu Phe Phe Gln Glu Pro Ala Ser Ala Val Ala Ser Phe 
            100                 105                 110         


Leu Asn Gly Leu Ala Ser Leu Val Met Leu Cys Arg Tyr Arg Thr Phe 
        115                 120                 125             


Val Pro Ala Ser Ser Pro Met Tyr His Thr Cys Val Ala Phe Ala Trp 
    130                 135                 140                 


Val Ser Leu Asn Ala Trp Phe Trp Ser Thr Val Phe His Thr Arg Asp 
145                 150                 155                 160 


Thr Asp Leu Thr Glu Lys Met Asp Tyr Phe Cys Ala Ser Thr Val Ile 
                165                 170                 175     


Leu His Ser Ile Tyr Leu Cys Cys Val Arg Thr Val Gly Leu Gln His 
            180                 185                 190         


Pro Ala Val Val Ser Ala Phe Arg Ala Leu Leu Leu Leu Met Leu Thr 
        195                 200                 205             


Val His Val Ser Tyr Leu Ser Leu Ile Arg Phe Asp Tyr Gly Tyr Asn 
    210                 215                 220                 


Leu Val Ala Asn Val Ala Ile Gly Leu Val Asn Val Val Trp Trp Leu 
225                 230                 235                 240 


Ala Trp Cys Leu Trp Asn Gln Arg Arg Leu Pro His Val Arg Lys Cys 
                245                 250                 255     


Val Val Val Val Leu Leu Leu Gln Gly Leu Ser Leu Leu Glu Leu Leu 
            260                 265                 270         


Asp Phe Pro Pro Leu Phe Trp Val Leu Asp Ala His Ala Ile Trp His 
        275                 280                 285             


Ile Ser Thr Ile Pro Val His Val Leu Phe Phe Ser Phe Leu Glu Asp 
    290                 295                 300                 


Asp Ser Leu Tyr Leu Leu Lys Glu Ser Glu Asp Lys Phe Lys Leu Asp 
305                 310                 315                 320 


<210>  5496
<211>  408
<212>  PRT
<213>  Homo sapiens

<400>  5496

Met Ser Glu His Val Glu Pro Ala Ala Pro Gly Pro Gly Pro Asn Gly 
1               5                   10                  15      


Gly Gly Gly Gly Pro Ala Pro Ala Arg Gly Pro Arg Thr Pro Asn Leu 
            20                  25                  30          


Asn Pro Asn Pro Leu Ile Asn Val Arg Asp Arg Leu Phe His Ala Leu 
        35                  40                  45              


Phe Phe Lys Met Ala Val Thr Tyr Ser Arg Leu Phe Pro Pro Ala Phe 
    50                  55                  60                  


Arg Arg Leu Phe Glu Phe Phe Val Leu Leu Lys Ala Leu Phe Val Leu 
65                  70                  75                  80  


Phe Val Leu Ala Tyr Ile His Ile Val Phe Ser Arg Ser Pro Ile Asn 
                85                  90                  95      


Cys Leu Glu His Val Arg Asp Lys Trp Pro Arg Glu Gly Ile Leu Arg 
            100                 105                 110         


Val Glu Val Arg His Asn Ser Ser Arg Ala Pro Val Phe Leu Gln Phe 
        115                 120                 125             


Cys Asp Ser Gly Gly Arg Gly Ser Phe Pro Gly Leu Ala Val Glu Pro 
    130                 135                 140                 


Gly Ser Asn Leu Asp Met Glu Asp Glu Glu Glu Glu Glu Leu Thr Met 
145                 150                 155                 160 


Glu Met Phe Gly Asn Ser Ser Ile Lys Phe Glu Leu Asp Ile Glu Pro 
                165                 170                 175     


Lys Val Phe Lys Pro Pro Ser Ser Thr Glu Ala Leu Asn Asp Ser Gln 
            180                 185                 190         


Glu Phe Pro Phe Pro Glu Thr Pro Thr Lys Val Trp Pro Gln Asp Glu 
        195                 200                 205             


Tyr Ile Val Glu Tyr Ser Leu Glu Tyr Gly Phe Leu Arg Leu Ser Gln 
    210                 215                 220                 


Ala Thr Arg Gln Arg Leu Ser Ile Pro Val Met Val Val Thr Leu Asp 
225                 230                 235                 240 


Pro Thr Arg Asp Gln Cys Phe Gly Asp Arg Phe Ser Arg Leu Leu Leu 
                245                 250                 255     


Asp Glu Phe Leu Gly Tyr Asp Asp Ile Leu Met Ser Ser Val Lys Gly 
            260                 265                 270         


Leu Ala Glu Asn Glu Glu Asn Lys Gly Phe Leu Arg Asn Val Val Ser 
        275                 280                 285             


Gly Glu His Tyr Arg Phe Val Ser Met Trp Met Ala Arg Thr Ser Tyr 
    290                 295                 300                 


Leu Ala Ala Phe Ala Ile Met Val Ile Phe Thr Leu Ser Val Ser Met 
305                 310                 315                 320 


Leu Leu Arg Tyr Ser His His Gln Ile Phe Val Phe Ile Val Asp Leu 
                325                 330                 335     


Leu Gln Met Leu Glu Met Asn Met Ala Ile Ala Phe Pro Ala Ala Pro 
            340                 345                 350         


Leu Leu Thr Val Ile Leu Ala Leu Val Gly Met Glu Ala Ile Met Ser 
        355                 360                 365             


Glu Phe Phe Asn Asp Thr Thr Thr Ala Phe Tyr Ile Ile Leu Ile Val 
    370                 375                 380                 


Trp Leu Ala Asp Gln Tyr Asp Ala Ile Cys Cys His Thr Ser Thr Ser 
385                 390                 395                 400 


Lys Arg His Trp Leu Arg Ile Pro 
                405             


<210>  5497
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  5497

Met Gly Ser Arg Leu Ser Gln Pro Phe Glu Ser Tyr Ile Thr Ala Pro 
1               5                   10                  15      


Pro Gly Thr Ala Ala Ala Pro Ala Lys Pro Ala Pro Pro Ala Thr Pro 
            20                  25                  30          


Gly Ala Pro Thr Ser Pro Ala Glu His Arg Leu Leu Lys Thr Cys Trp 
        35                  40                  45              


Ser Cys Arg Val Leu Ser Gly Leu Gly Leu Met Gly Ala Gly Gly Tyr 
    50                  55                  60                  


Val Tyr Trp Val Ala Arg Lys Pro Met Lys Met Gly Tyr Pro Pro Ser 
65                  70                  75                  80  


Pro Trp Thr Ile Thr Gln Met Val Ile Gly Leu Ser Ile Ala Thr Trp 
                85                  90                  95      


Gly Ile Val Val Met Ala Asp Pro Lys Gly Lys Ala Tyr Arg Val Val 
            100                 105                 110         


<210>  5498
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  5498

Met Cys Ala Phe Pro Trp Leu Leu Leu Leu Leu Leu Leu Gln Glu Gly 
1               5                   10                  15      


Ser Gln Arg Arg Leu Trp Arg Trp Cys Gly Ser Glu Glu Val Val Ala 
            20                  25                  30          


Val Leu Gln Glu Ser Ile Ser Leu Pro Leu Glu Ile Pro Pro Asp Glu 
        35                  40                  45              


Glu Val Glu Asn Ile Ile Trp Ser Ser His Lys Ser Leu Ala Thr Val 
    50                  55                  60                  


Val Pro Gly Lys Glu Gly His Pro Ala Thr Ile Met Val Thr Asn Pro 
65                  70                  75                  80  


His Tyr Gln Gly Gln Val Ser Phe Leu Asp Pro Ser Tyr Ser Leu His 
                85                  90                  95      


Ile Ser Asn Leu Ser Trp Glu Asp Ser Gly Leu Tyr Gln Ala Gln Val 
            100                 105                 110         


Asn Leu Arg Thr Ser Gln Ile Ser Thr Met Gln Gln Tyr Asn Ile Cys 
        115                 120                 125             


Val Tyr Arg Trp Leu Ser Glu Pro Gln Ile Thr Val Asn Phe Glu Ser 
    130                 135                 140                 


Ser Gly Glu Gly Ala Cys Ser Met Ser Leu Val Cys Ser Val Glu Lys 
145                 150                 155                 160 


Ala Gly Met Asp Met Thr Tyr Ser Trp Leu Ser Arg Gly Asp Ser Thr 
                165                 170                 175     


Tyr Thr Phe His Glu Gly Pro Val Leu Ser Thr Ser Trp Arg Pro Gly 
            180                 185                 190         


Asp Ser Ala Leu Ser Tyr Thr Cys Arg Ala Asn Asn Pro Ile Ser Asn 
        195                 200                 205             


Val Ser Ser Cys Pro Ile Pro Asp Gly Pro Phe Tyr Ala Asp Pro Asn 
    210                 215                 220                 


Tyr Ala Ser Glu Lys Pro Ser Thr Ala Phe Cys Leu Leu Ala Lys Gly 
225                 230                 235                 240 


Leu Leu Ile Phe Leu Leu Leu Val Ile Leu Ala Met Gly Leu Trp Val 
                245                 250                 255     


Ile Arg Val Gln Lys Arg His Lys Met Pro Arg Met Lys Lys Leu Met 
            260                 265                 270         


Arg Asn Arg Met Lys Leu Arg Lys Glu Ala Lys Pro Gly Ser Ser Pro 
        275                 280                 285             


Ala 
    


<210>  5499
<211>  1464
<212>  PRT
<213>  Homo sapiens

<400>  5499

Met Cys Leu Leu Val Phe Pro Leu Val Pro Arg Ser Pro Asp Tyr Ile 
1               5                   10                  15      


Leu Pro Cys Ser Pro Gly Trp Arg Leu Arg Leu Ala Ala Ser Phe Leu 
            20                  25                  30          


Leu Ser Val Phe Pro Leu Leu Asp Leu Leu Pro Val Ala Leu Pro Pro 
        35                  40                  45              


Gly Ala Gly Pro Gly Pro Ile Gly Leu Glu Val Leu Ala Gly Cys Val 
    50                  55                  60                  


Ala Ala Val Ala Trp Ile Ser His Ser Leu Ala Leu Trp Val Leu Ala 
65                  70                  75                  80  


His Ser Pro His Gly His Ser Arg Gly Pro Leu Ala Leu Ala Leu Val 
                85                  90                  95      


Ala Leu Leu Pro Ala Pro Ala Leu Val Leu Thr Val Leu Trp His Cys 
            100                 105                 110         


Gln Arg Gly Thr Leu Leu Pro Pro Leu Leu Pro Gly Pro Met Ala Arg 
        115                 120                 125             


Leu Cys Leu Leu Ile Leu Gln Leu Ala Ala Leu Leu Ala Tyr Ala Leu 
    130                 135                 140                 


Gly Trp Ala Ala Pro Gly Gly Pro Arg Glu Pro Trp Ala Gln Glu Pro 
145                 150                 155                 160 


Leu Leu Pro Glu Asp Gln Glu Pro Glu Val Ala Glu Asp Gly Glu Ser 
                165                 170                 175     


Trp Leu Ser Arg Phe Ser Tyr Ala Trp Leu Ala Pro Leu Leu Ala Arg 
            180                 185                 190         


Gly Ala Cys Gly Glu Leu Arg Gln Pro Gln Asp Ile Cys Arg Leu Pro 
        195                 200                 205             


His Arg Leu Gln Pro Thr Tyr Leu Ala Arg Val Phe Gln Ala His Trp 
    210                 215                 220                 


Gln Glu Gly Ala Arg Leu Trp Arg Ala Leu Tyr Gly Ala Phe Gly Arg 
225                 230                 235                 240 


Cys Tyr Leu Ala Leu Gly Leu Leu Lys Leu Val Gly Thr Met Leu Gly 
                245                 250                 255     


Phe Ser Gly Pro Leu Leu Leu Ser Leu Leu Val Gly Phe Leu Glu Glu 
            260                 265                 270         


Gly Gln Glu Pro Leu Ser His Gly Leu Leu Tyr Ala Leu Gly Leu Ala 
        275                 280                 285             


Gly Gly Ala Val Leu Gly Ala Val Leu Gln Asn Gln Tyr Gly Tyr Glu 
    290                 295                 300                 


Val Tyr Lys Val Thr Leu Gln Ala Arg Gly Ala Val Leu Asn Ile Leu 
305                 310                 315                 320 


Tyr Cys Lys Ala Leu Gln Leu Gly Pro Ser Arg Pro Pro Thr Gly Glu 
                325                 330                 335     


Ala Leu Asn Leu Leu Gly Thr Asp Ser Glu Arg Leu Leu Asn Phe Ala 
            340                 345                 350         


Gly Ser Phe His Glu Ala Trp Gly Leu Pro Leu Gln Leu Ala Ile Thr 
        355                 360                 365             


Leu Tyr Leu Leu Tyr Gln Gln Val Gly Val Ala Phe Val Gly Gly Leu 
    370                 375                 380                 


Ile Leu Ala Leu Leu Leu Val Pro Val Asn Lys Val Ile Ala Thr Arg 
385                 390                 395                 400 


Ile Met Ala Ser Asn Gln Glu Met Leu Gln His Lys Asp Ala Arg Val 
                405                 410                 415     


Lys Leu Val Thr Glu Leu Leu Ser Gly Ile Arg Val Ile Lys Phe Cys 
            420                 425                 430         


Gly Trp Glu Gln Ala Leu Gly Ala Arg Val Glu Ala Cys Arg Ala Arg 
        435                 440                 445             


Glu Leu Gly Arg Leu Arg Val Ile Lys Tyr Leu Asp Ala Ala Cys Val 
    450                 455                 460                 


Tyr Leu Trp Ala Ala Leu Pro Val Val Ile Ser Ile Val Ile Phe Ile 
465                 470                 475                 480 


Thr Tyr Val Leu Met Gly His Gln Leu Thr Ala Thr Lys Val Phe Thr 
                485                 490                 495     


Ala Leu Ala Leu Val Arg Met Leu Ile Leu Pro Leu Asn Asn Phe Pro 
            500                 505                 510         


Trp Val Ile Asn Gly Leu Leu Glu Ala Lys Val Ser Leu Asp Arg Ile 
        515                 520                 525             


Gln Leu Phe Leu Asp Leu Pro Asn His Asn Pro Gln Ala Tyr Tyr Ser 
    530                 535                 540                 


Pro Asp Cys Gly Arg Leu Gly Ala Gln Ile Lys Trp Leu Leu Cys Ser 
545                 550                 555                 560 


Asp Pro Pro Ala Glu Pro Ser Thr Val Leu Glu Leu His Gly Ala Leu 
                565                 570                 575     


Phe Ser Trp Asp Pro Val Gly Thr Ser Leu Glu Thr Phe Ile Ser His 
            580                 585                 590         


Leu Glu Val Lys Lys Gly Met Leu Val Gly Ile Val Gly Lys Val Gly 
        595                 600                 605             


Cys Gly Lys Ser Ser Leu Leu Ala Ala Ile Ala Gly Glu Leu His Arg 
    610                 615                 620                 


Leu Arg Gly His Val Ala Val Arg Gly Leu Ser Lys Gly Phe Gly Leu 
625                 630                 635                 640 


Ala Thr Gln Glu Pro Trp Ile Gln Phe Ala Thr Ile Arg Asp Asn Ile 
                645                 650                 655     


Leu Phe Gly Lys Thr Phe Asp Ala Gln Leu Tyr Lys Glu Val Leu Glu 
            660                 665                 670         


Ala Cys Ala Leu Asn Asp Asp Leu Ser Ile Leu Pro Ala Gly Asp Gln 
        675                 680                 685             


Thr Glu Val Gly Glu Lys Gly Val Thr Leu Ser Gly Gly Gln Arg Ala 
    690                 695                 700                 


Arg Ile Ala Leu Ala Arg Ala Val Tyr Gln Glu Lys Glu Leu Tyr Leu 
705                 710                 715                 720 


Leu Asp Asp Pro Leu Ala Ala Val Asp Ala Asp Val Ala Asn His Leu 
                725                 730                 735     


Leu His Arg Cys Ile Leu Gly Met Leu Ser Tyr Thr Thr Arg Leu Leu 
            740                 745                 750         


Cys Thr His Arg Thr Glu Tyr Leu Glu Arg Ala Asp Ala Val Leu Leu 
        755                 760                 765             


Met Glu Ala Gly Arg Leu Ile Arg Ala Gly Pro Pro Ser Glu Ile Leu 
    770                 775                 780                 


Pro Leu Val Gln Ala Val Pro Lys Ala Trp Ala Glu Asn Gly Gln Glu 
785                 790                 795                 800 


Ser Asp Ser Ala Thr Ala Gln Ser Val Gln Asn Pro Glu Lys Thr Lys 
                805                 810                 815     


Glu Gly Leu Glu Glu Glu Gln Ser Thr Ser Gly Arg Leu Leu Gln Glu 
            820                 825                 830         


Glu Ser Lys Lys Glu Gly Ala Val Ala Leu His Val Tyr Gln Ala Tyr 
        835                 840                 845             


Trp Lys Ala Val Gly Gln Gly Leu Ala Leu Ala Ile Leu Phe Ser Leu 
    850                 855                 860                 


Leu Leu Met Gln Ala Thr Arg Asn Ala Ala Asp Trp Trp Leu Ser His 
865                 870                 875                 880 


Trp Ile Ser Gln Leu Lys Ala Glu Asn Ser Ser Gln Glu Ala Gln Pro 
                885                 890                 895     


Ser Thr Ser Pro Ala Ser Met Gly Leu Phe Ser Pro Gln Leu Leu Leu 
            900                 905                 910         


Phe Ser Pro Gly Asn Leu Tyr Ile Pro Val Phe Pro Leu Pro Lys Ala 
        915                 920                 925             


Ala Pro Asn Gly Ser Ser Asp Ile Arg Phe Tyr Leu Thr Val Tyr Ala 
    930                 935                 940                 


Thr Ile Ala Gly Val Asn Ser Leu Cys Thr Leu Leu Arg Ala Val Leu 
945                 950                 955                 960 


Phe Ala Ala Gly Thr Leu Gln Ala Ala Ala Thr Leu His Arg Arg Leu 
                965                 970                 975     


Leu His Arg Val Leu Met Ala Pro Val Thr Phe Phe Asn Ala Thr Pro 
            980                 985                 990         


Thr Gly Arg Ile Leu Asn Arg Phe  Ser Ser Asp Val Ala  Cys Ala Asp 
        995                 1000                 1005             


Asp Ser  Leu Pro Phe Ile Leu  Asn Ile Leu Leu Ala  Asn Ala Ala 
    1010                 1015                 1020             


Gly Leu  Leu Gly Leu Leu Ala  Val Leu Gly Ser Gly  Leu Pro Trp 
    1025                 1030                 1035             


Leu Leu  Leu Leu Leu Pro Pro  Leu Ser Ile Met Tyr  Tyr His Val 
    1040                 1045                 1050             


Gln Arg  His Tyr Arg Ala Ser  Ser Arg Glu Leu Arg  Arg Leu Gly 
    1055                 1060                 1065             


Ser Leu  Thr Leu Ser Pro Leu  Tyr Ser His Leu Ala  Asp Thr Leu 
    1070                 1075                 1080             


Ala Gly  Leu Ser Val Leu Arg  Ala Thr Gly Ala Thr  Tyr Arg Phe 
    1085                 1090                 1095             


Glu Glu  Glu Asn Leu Arg Leu  Leu Glu Leu Asn Gln  Arg Cys Gln 
    1100                 1105                 1110             


Phe Ala  Thr Ser Ala Thr Met  Gln Trp Leu Asp Ile  Arg Leu Gln 
    1115                 1120                 1125             


Leu Met  Gly Ala Ala Val Val  Ser Ala Ile Ala Gly  Ile Ala Leu 
    1130                 1135                 1140             


Val Gln  His Gln Gln Gly Leu  Ala Asn Pro Gly Leu  Val Gly Leu 
    1145                 1150                 1155             


Ser Leu  Ser Tyr Ala Leu Ser  Leu Thr Gly Leu Leu  Ser Gly Leu 
    1160                 1165                 1170             


Val Ser  Ser Phe Thr Gln Thr  Glu Ala Met Leu Val  Ser Val Glu 
    1175                 1180                 1185             


Arg Leu  Glu Glu Tyr Thr Cys  Asp Leu Pro Gln Glu  Pro Gln Gly 
    1190                 1195                 1200             


Gln Pro  Leu Gln Leu Gly Thr  Gly Trp Leu Thr Gln  Gly Gly Val 
    1205                 1210                 1215             


Glu Phe  Gln Asp Val Val Leu  Ala Tyr Arg Pro Gly  Leu Pro Asn 
    1220                 1225                 1230             


Ala Leu  Asp Gly Val Thr Phe  Cys Val Gln Pro Gly  Glu Lys Leu 
    1235                 1240                 1245             


Gly Ile  Val Gly Arg Thr Gly  Ser Gly Lys Ser Ser  Leu Leu Leu 
    1250                 1255                 1260             


Val Leu  Phe Arg Leu Leu Glu  Pro Ser Ser Gly Arg  Val Leu Leu 
    1265                 1270                 1275             


Asp Gly  Val Asp Thr Ser Gln  Leu Glu Leu Ala Gln  Leu Arg Ser 
    1280                 1285                 1290             


Gln Leu  Ala Ile Ile Pro Gln  Glu Pro Phe Leu Phe  Ser Gly Thr 
    1295                 1300                 1305             


Val Arg  Glu Asn Leu Asp Pro  Gln Gly Leu His Lys  Asp Arg Ala 
    1310                 1315                 1320             


Leu Trp  Gln Ala Leu Lys Gln  Cys His Leu Ser Glu  Val Ile Thr 
    1325                 1330                 1335             


Ser Met  Gly Gly Leu Asp Gly  Glu Leu Gly Glu Gly  Gly Arg Ser 
    1340                 1345                 1350             


Leu Ser  Leu Gly Gln Arg Gln  Leu Leu Cys Leu Ala  Arg Ala Leu 
    1355                 1360                 1365             


Leu Thr  Asp Ala Lys Ile Leu  Cys Ile Asp Glu Ala  Thr Ala Ser 
    1370                 1375                 1380             


Val Asp  Gln Lys Thr Asp Gln  Leu Leu Gln Gln Thr  Ile Cys Lys 
    1385                 1390                 1395             


Arg Phe  Ala Asn Lys Thr Val  Leu Thr Ile Ala His  Arg Leu Asn 
    1400                 1405                 1410             


Thr Ile  Leu Asn Ser Asp Arg  Val Leu Val Leu Gln  Ala Gly Arg 
    1415                 1420                 1425             


Val Val  Glu Leu Asp Ser Pro  Ala Thr Leu Arg Asn  Gln Pro His 
    1430                 1435                 1440             


Ser Leu  Phe Gln Gln Leu Leu  Gln Ser Ser Gln Gln  Gly Val Pro 
    1445                 1450                 1455             


Ala Ser  Leu Gly Gly Pro 
    1460                 


<210>  5500
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  5500

Met Gly Gly Leu Arg Pro Trp Ser Arg Tyr Gly Leu Leu Val Val Ala 
1               5                   10                  15      


His Leu Leu Ala Leu Gly Leu Gly Ala Val Val Phe Gln Ala Leu Glu 
            20                  25                  30          


Gly Pro Pro Ala Cys Arg Leu Gln Ala Glu Leu Arg Ala Glu Leu Ala 
        35                  40                  45              


Ala Phe Gln Ala Glu His Arg Ala Cys Leu Pro Pro Gly Ala Leu Glu 
    50                  55                  60                  


Glu Leu Leu Gly Thr Ala Leu Ala Thr Gln Ala His Gly Val Ser Thr 
65                  70                  75                  80  


Leu Gly Asn Ser Ser Glu Gly Arg Thr Trp Asp Leu Pro Ser Ala Leu 
                85                  90                  95      


Leu Phe Ala Ala Ser Ile Leu Thr Thr Thr Gly Tyr Gly His Met Ala 
            100                 105                 110         


Pro Leu Ser Pro Gly Gly Lys Ala Phe Cys Met Val Tyr Ala Ala Leu 
        115                 120                 125             


Gly Leu Pro Ala Ser Leu Ala Leu Val Ala Thr Leu Arg His Cys Leu 
    130                 135                 140                 


Leu Pro Val Leu Ser Arg Pro Arg Ala Trp Val Ala Val His Trp Gln 
145                 150                 155                 160 


Leu Ser Pro Ala Arg Ala Ala Leu Leu Gln Ala Val Ala Leu Gly Leu 
                165                 170                 175     


Leu Val Ala Ser Ser Phe Val Leu Leu Pro Ala Leu Val Leu Trp Gly 
            180                 185                 190         


Leu Gln Gly Asp Cys Ser Leu Leu Gly Ala Val Tyr Phe Cys Phe Ser 
        195                 200                 205             


Ser Leu Ser Thr Ile Gly Leu Glu Asp Leu Leu Pro Gly Arg Gly Arg 
    210                 215                 220                 


Ser Leu His Pro Val Ile Tyr His Leu Gly Gln Leu Ala Leu Leu Gly 
225                 230                 235                 240 


Gly Gly Thr Ser Leu Gln Gly Thr Ala Trp Glu Gly 
                245                 250         


<210>  5501
<211>  779
<212>  PRT
<213>  Homo sapiens

<400>  5501

Met Gly Lys Ser Glu Gly Pro Val Gly Met Val Glu Ser Ala Gly Arg 
1               5                   10                  15      


Ala Gly Gln Lys Arg Pro Gly Phe Leu Glu Gly Gly Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Val Thr Ala Ala Leu Val Ala Leu Gly Val Leu Tyr Ala 
        35                  40                  45              


Asp Arg Arg Gly Lys Gln Leu Pro Arg Leu Ala Ser Arg Leu Cys Phe 
    50                  55                  60                  


Leu Gln Glu Glu Arg Thr Phe Val Lys Arg Lys Pro Arg Gly Ile Pro 
65                  70                  75                  80  


Glu Ala Gln Glu Val Ser Glu Val Cys Thr Thr Pro Gly Cys Val Ile 
                85                  90                  95      


Ala Ala Ala Arg Ile Leu Gln Asn Met Asp Pro Thr Thr Glu Pro Cys 
            100                 105                 110         


Asp Asp Phe Tyr Gln Phe Ala Cys Gly Gly Trp Leu Arg Arg His Val 
        115                 120                 125             


Ile Pro Glu Thr Asn Ser Arg Tyr Ser Ile Phe Asp Val Leu Arg Asp 
    130                 135                 140                 


Glu Leu Glu Val Ile Leu Lys Ala Val Leu Glu Asn Ser Thr Ala Lys 
145                 150                 155                 160 


Asp Arg Pro Ala Val Glu Lys Ala Arg Thr Leu Tyr Arg Ser Cys Met 
                165                 170                 175     


Asn Gln Ser Val Ile Glu Lys Arg Gly Ser Gln Pro Leu Leu Asp Ile 
            180                 185                 190         


Leu Glu Val Val Gly Gly Trp Pro Val Ala Met Asp Arg Trp Asn Glu 
        195                 200                 205             


Thr Val Gly Leu Glu Trp Glu Leu Glu Arg Gln Leu Ala Leu Met Asn 
    210                 215                 220                 


Ser Gln Phe Asn Arg Arg Val Leu Ile Asp Leu Phe Ile Trp Asn Asp 
225                 230                 235                 240 


Asp Gln Asn Ser Ser Arg His Ile Ile Tyr Ile Asp Gln Pro Thr Leu 
                245                 250                 255     


Gly Met Pro Ser Arg Glu Tyr Tyr Phe Asn Gly Gly Ser Asn Arg Lys 
            260                 265                 270         


Val Arg Glu Ala Tyr Leu Gln Phe Met Val Ser Val Ala Thr Leu Leu 
        275                 280                 285             


Arg Glu Asp Ala Asn Leu Pro Arg Asp Ser Cys Leu Val Gln Glu Asp 
    290                 295                 300                 


Met Val Gln Val Leu Glu Leu Glu Thr Gln Leu Ala Lys Ala Thr Val 
305                 310                 315                 320 


Pro Gln Glu Glu Arg His Asp Val Ile Ala Leu Tyr His Arg Met Gly 
                325                 330                 335     


Leu Glu Glu Leu Gln Ser Gln Phe Gly Leu Lys Gly Phe Asn Trp Thr 
            340                 345                 350         


Leu Phe Ile Gln Thr Val Leu Ser Ser Val Lys Ile Lys Leu Leu Pro 
        355                 360                 365             


Asp Glu Glu Val Val Val Tyr Gly Ile Pro Tyr Leu Gln Asn Leu Glu 
    370                 375                 380                 


Asn Ile Ile Asp Thr Tyr Ser Ala Arg Thr Ile Gln Asn Tyr Leu Val 
385                 390                 395                 400 


Trp Arg Leu Val Leu Asp Arg Ile Gly Ser Leu Ser Gln Arg Phe Lys 
                405                 410                 415     


Asp Thr Arg Val Asn Tyr Arg Lys Ala Leu Phe Gly Thr Met Val Glu 
            420                 425                 430         


Glu Val Arg Trp Arg Glu Cys Val Gly Tyr Val Asn Ser Asn Met Glu 
        435                 440                 445             


Asn Ala Val Gly Ser Leu Tyr Val Arg Glu Ala Phe Pro Gly Asp Ser 
    450                 455                 460                 


Lys Ser Met Val Arg Glu Leu Ile Asp Lys Val Arg Thr Val Phe Val 
465                 470                 475                 480 


Glu Thr Leu Asp Glu Leu Gly Trp Met Asp Glu Glu Ser Lys Lys Lys 
                485                 490                 495     


Ala Gln Glu Lys Ala Met Ser Ile Arg Glu Gln Ile Gly His Pro Asp 
            500                 505                 510         


Tyr Ile Leu Glu Glu Met Asn Arg Arg Leu Asp Glu Glu Tyr Ser Asn 
        515                 520                 525             


Leu Asn Phe Ser Glu Asp Leu Tyr Phe Glu Asn Ser Leu Gln Asn Leu 
    530                 535                 540                 


Lys Val Gly Ala Gln Arg Ser Leu Arg Lys Leu Arg Glu Lys Val Asp 
545                 550                 555                 560 


Pro Asn Leu Trp Ile Ile Gly Ala Ala Val Val Asn Ala Phe Tyr Ser 
                565                 570                 575     


Pro Asn Arg Asn Gln Ile Val Phe Pro Ala Gly Ile Leu Gln Pro Pro 
            580                 585                 590         


Phe Phe Ser Lys Glu Gln Pro Gln Ala Leu Asn Phe Gly Gly Ile Gly 
        595                 600                 605             


Met Val Ile Gly His Glu Ile Thr His Gly Phe Asp Asp Asn Gly Arg 
    610                 615                 620                 


Asn Phe Asp Lys Asn Gly Asn Met Met Asp Trp Trp Ser Asn Phe Ser 
625                 630                 635                 640 


Thr Gln His Phe Arg Glu Gln Ser Glu Cys Met Ile Tyr Gln Tyr Gly 
                645                 650                 655     


Asn Tyr Ser Trp Asp Leu Ala Asp Glu Gln Asn Val Asn Gly Phe Asn 
            660                 665                 670         


Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Val Arg Gln Ala Tyr 
        675                 680                 685             


Lys Ala Tyr Leu Lys Trp Met Ala Glu Gly Gly Lys Asp Gln Gln Leu 
    690                 695                 700                 


Pro Gly Leu Asp Leu Thr His Glu Gln Leu Phe Phe Ile Asn Tyr Ala 
705                 710                 715                 720 


Gln Val Trp Cys Gly Ser Tyr Arg Pro Glu Phe Ala Ile Gln Ser Ile 
                725                 730                 735     


Lys Thr Asp Val His Ser Pro Leu Lys Tyr Arg Val Leu Gly Ser Leu 
            740                 745                 750         


Gln Asn Leu Ala Ala Phe Ala Asp Thr Phe His Cys Ala Arg Gly Thr 
        755                 760                 765             


Pro Met His Pro Lys Glu Arg Cys Arg Val Trp 
    770                 775                 


<210>  5502
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  5502

Met Cys Leu Arg Leu Gly Gly Leu Ser Val Gly Asp Phe Arg Lys Val 
1               5                   10                  15      


Leu Met Lys Thr Gly Leu Val Leu Val Val Leu Gly His Val Ser Phe 
            20                  25                  30          


Ile Thr Ala Ala Leu Phe His Gly Thr Val Leu Arg Tyr Val Gly Thr 
        35                  40                  45              


Pro Gln Asp Ala Val Ala Leu Gln Tyr Cys Val Val Asn Ile Leu Ser 
    50                  55                  60                  


Val Thr Ser Ala Ile Val Val Ile Thr Ser Gly Ile Ala Ala Ile Val 
65                  70                  75                  80  


Leu Ser Arg Tyr Leu Pro Ser Thr Pro Leu Arg Trp Thr Val Phe Ser 
                85                  90                  95      


Ser Ser Val Ala Cys Ala Leu Leu Ser Leu Thr Cys Ala Leu Gly Leu 
            100                 105                 110         


Leu Ala Ser Ile Ala Met Thr Phe Ala Thr Gln Gly Lys Ala Leu Leu 
        115                 120                 125             


Ala Ala Cys Thr Phe Gly Ser Ser Glu Leu Leu Ala Leu Ala Pro Asp 
    130                 135                 140                 


Cys Pro Phe Asp Pro Thr Arg Ile Tyr Ser Ser Ser Leu Cys Leu Trp 
145                 150                 155                 160 


Gly Ile Ala Leu Val Leu Cys Val Ala Glu Asn Val Phe Ala Val Arg 
                165                 170                 175     


Cys Ala Gln Leu Thr His Gln Leu Leu Glu Leu Arg Pro Trp Trp Gly 
            180                 185                 190         


Lys Ser Ser His His Met Met Arg Glu Asn Pro Glu Leu Val Glu Gly 
        195                 200                 205             


Arg Asp Leu Leu Ser Cys Thr Ser Ser Glu Pro Leu Thr Leu 
    210                 215                 220         


<210>  5503
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  5503

Met Ala Gly Tyr Glu Tyr Val Ser Pro Glu Gln Leu Ala Gly Phe Asp 
1               5                   10                  15      


Lys Tyr Lys Tyr Ser Ala Val Asp Thr Asn Pro Leu Ser Leu Tyr Val 
            20                  25                  30          


Met His Pro Phe Trp Asn Thr Ile Val Lys Val Phe Pro Thr Trp Leu 
        35                  40                  45              


Ala Pro Asn Leu Ile Thr Phe Ser Gly Phe Leu Leu Val Val Phe Asn 
    50                  55                  60                  


Phe Leu Leu Met Ala Tyr Phe Asp Pro Asp Phe Tyr Ala Ser Ala Pro 
65                  70                  75                  80  


Gly His Lys His Val Pro Asp Trp Val Trp Ile Val Val Gly Ile Leu 
                85                  90                  95      


Asn Phe Val Ala Tyr Thr Leu Asp Gly Val Asp Gly Lys Gln Ala Arg 
            100                 105                 110         


Arg Thr Asn Ser Ser Thr Pro Leu Gly Glu Leu Phe Asp His Gly Leu 
        115                 120                 125             


Asp Ser Trp Ser Cys Val Tyr Phe Val Val Thr Val Tyr Ser Ile Phe 
    130                 135                 140                 


Gly Arg Gly Ser Thr Gly Val Ser Val Phe Val Leu Tyr Leu Leu Leu 
145                 150                 155                 160 


Trp Val Val Leu Phe Ser Phe Ile Leu Ser His Trp Glu Lys Tyr Asn 
                165                 170                 175     


Thr Gly Ile Leu Phe Leu Pro Trp Gly Tyr Asp Ile Ser Gln Val Thr 
            180                 185                 190         


Ile Ser Phe Val Tyr Ile Val Thr Ala Val Val Gly Val Glu Ala Trp 
        195                 200                 205             


Tyr Glu Pro Phe Leu Phe Asn Phe Leu Tyr Arg Asp Leu Phe Thr Ala 
    210                 215                 220                 


Met Ile Ile Gly Cys Ala Leu Cys Val Thr Leu Pro Met Ser Leu Leu 
225                 230                 235                 240 


Asn Phe Phe Arg Ser Tyr Lys Asn Asn Thr Leu Lys Leu Asn Ser Val 
                245                 250                 255     


Tyr Glu Ala Met Val Pro Leu Phe Ser Pro Cys Leu Leu Phe Ile Leu 
            260                 265                 270         


Ser Thr Ala Trp Ile Leu Trp Ser Pro Ser Asp Ile Leu Glu Leu His 
        275                 280                 285             


Pro Arg Val Phe Tyr Phe Met Val Gly Thr Ala Phe Ala Asn Ser Thr 
    290                 295                 300                 


Cys Gln Leu Ile Val Cys Gln Met Ser Ser Thr Arg Cys Pro Thr Leu 
305                 310                 315                 320 


Asn Trp Leu Leu Val Pro Leu Phe Leu Val Val Leu Val Val Asn Leu 
                325                 330                 335     


Gly Val Ala Ser Tyr Val Glu Ser Ile Leu Leu Tyr Thr Leu Thr Thr 
            340                 345                 350         


Ala Phe Thr Leu Ala His Ile His Tyr Gly Val Arg Val Val Lys Gln 
        355                 360                 365             


Leu Ser Ser His Phe Gln Ile Tyr Pro Phe Ser Leu Arg Lys Pro Asn 
    370                 375                 380                 


Ser Asp Leu Gly Met Glu Glu Lys Asn Ile Gly Leu 
385                 390                 395     


<210>  5504
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  5504

Met Glu Leu Gln Asp Pro Lys Met Asn Gly Ala Leu Pro Ser Asp Ala 
1               5                   10                  15      


Val Gly Tyr Arg Gln Glu Arg Glu Gly Phe Leu Pro Ser Arg Gly Pro 
            20                  25                  30          


Ala Pro Gly Ser Lys Pro Val Gln Phe Met Asp Phe Glu Gly Lys Thr 
        35                  40                  45              


Ser Phe Gly Met Ser Val Phe Asn Leu Ser Asn Ala Ile Met Gly Ser 
    50                  55                  60                  


Gly Ile Leu Gly Leu Ala Tyr Ala Met Ala His Thr Gly Val Ile Phe 
65                  70                  75                  80  


Phe Leu Ala Leu Leu Leu Cys Ile Ala Leu Leu Ser Ser Tyr Ser Ile 
                85                  90                  95      


His Leu Leu Leu Thr Cys Ala Gly Ile Ala Gly Ile Arg Ala Tyr Glu 
            100                 105                 110         


Gln Leu Gly Gln Arg Ala Phe Gly Pro Ala Gly Lys Val Val Val Ala 
        115                 120                 125             


Thr Val Ile Cys Leu His Asn Val Gly Ala Met Ser Ser Tyr Leu Phe 
    130                 135                 140                 


Ile Ile Lys Ser Glu Leu Pro Leu Val Ile Gly Thr Phe Leu Tyr Met 
145                 150                 155                 160 


Asp Pro Glu Gly Asp Trp Phe Leu Lys Gly Asn Leu Leu Ile Ile Ile 
                165                 170                 175     


Val Ser Val Leu Ile Ile Leu Pro Leu Ala Leu Met Lys His Leu Gly 
            180                 185                 190         


Tyr Leu Gly Tyr Thr Ser Gly Leu Ser Leu Thr Cys Met Leu Phe Phe 
        195                 200                 205             


Leu Val Ser Val Ile Tyr Lys Lys Phe Gln Leu Gly Cys Ala Ile Gly 
    210                 215                 220                 


His Asn Glu Thr Ala Met Glu Ser Glu Ala Leu Val Gly Leu Pro Ser 
225                 230                 235                 240 


Gln Gly Leu Asn Ser Ser Cys Glu Ala Gln Met Phe Thr Val Asp Ser 
                245                 250                 255     


Gln Met Ser Tyr Thr Val Pro Ile Met Ala Phe Ala Phe Val Cys His 
            260                 265                 270         


Pro Glu Val Leu Pro Ile Tyr Thr Glu Leu Cys Arg Pro Ser Lys Arg 
        275                 280                 285             


Arg Met Gln Ala Val Ala Asn Val Ser Ile Gly Ala Met Phe Cys Met 
    290                 295                 300                 


Tyr Gly Leu Thr Ala Thr Phe Gly Tyr Leu Thr Phe Tyr Ser Ser Val 
305                 310                 315                 320 


Lys Ala Glu Met Leu His Met Tyr Ser Gln Lys Asp Pro Leu Ile Leu 
                325                 330                 335     


Cys Val Arg Leu Ala Val Leu Leu Ala Val Thr Leu Thr Val Pro Val 
            340                 345                 350         


Val Leu Phe Pro Ile Arg Arg Ala Leu Gln Gln Leu Leu Phe Pro Gly 
        355                 360                 365             


Lys Ala Phe Ser Trp Pro Arg His Val Ala Ile Ala Leu Ile Leu Leu 
    370                 375                 380                 


Val Leu Val Asn Val Leu Val Ile Cys Val Pro Thr Ile Arg Asp Ile 
385                 390                 395                 400 


Phe Gly Val Ile Gly Ser Thr Ser Ala Pro Ser Leu Ile Phe Ile Leu 
                405                 410                 415     


Pro Ser Ile Phe Tyr Leu Arg Ile Val Pro Ser Glu Val Glu Pro Phe 
            420                 425                 430         


Leu Ser Trp Pro Lys Ile Gln Ala Leu Cys Phe Gly Val Leu Gly Val 
        435                 440                 445             


Leu Phe Met Ala Val Ser Leu Gly Phe Met Phe Ala Asn Trp Ala Thr 
    450                 455                 460                 


Gly Gln Ser Arg Met Ser Gly His 
465                 470         


<210>  5505
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  5505

Met Ala Gly Gln Phe Arg Ser Tyr Val Trp Asp Pro Leu Leu Ile Leu 
1               5                   10                  15      


Ser Gln Ile Val Leu Met Gln Thr Val Tyr Tyr Gly Ser Leu Gly Leu 
            20                  25                  30          


Trp Leu Ala Leu Val Asp Gly Leu Val Arg Ser Ser Pro Ser Leu Asp 
        35                  40                  45              


Gln Met Phe Asp Ala Glu Ile Leu Gly Phe Ser Thr Pro Pro Gly Arg 
    50                  55                  60                  


Leu Ser Met Met Ser Phe Ile Leu Asn Ala Leu Thr Cys Ala Leu Gly 
65                  70                  75                  80  


Leu Leu Tyr Phe Ile Arg Arg Gly Lys Gln Cys Leu Asp Phe Thr Val 
                85                  90                  95      


Thr Val His Phe Phe His Leu Leu Gly Cys Trp Phe Tyr Ser Ser Arg 
            100                 105                 110         


Phe Pro Ser Ala Leu Thr Trp Trp Leu Val Gln Ala Val Cys Ile Ala 
        115                 120                 125             


Leu Met Ala Val Ile Gly Glu Tyr Leu Cys Met Arg Thr Glu Leu Lys 
    130                 135                 140                 


Glu Ile Pro Leu Asn Ser Ala Pro Lys Ser Asn Val 
145                 150                 155     


<210>  5506
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  5506

Met Gly Pro Pro Ser Ala Cys Pro His Arg Glu Cys Ile Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Ala Pro Thr 
            20                  25                  30          


Thr Ala Trp Leu Phe Ile Ala Ser Ala Pro Phe Glu Val Ala Glu Gly 
        35                  40                  45              


Glu Asn Val His Leu Ser Val Val Tyr Leu Pro Glu Asn Leu Tyr Ser 
    50                  55                  60                  


Tyr Gly Trp Tyr Lys Gly Lys Thr Val Glu Pro Asn Gln Leu Ile Ala 
65                  70                  75                  80  


Ala Tyr Val Ile Asp Thr His Val Arg Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Ser Pro Ser Gly Asp Leu His Phe Gln Asn Val 
            100                 105                 110         


Thr Leu Glu Asp Thr Gly Tyr Tyr Asn Leu Gln Val Thr Tyr Arg Asn 
        115                 120                 125             


Ser Gln Ile Glu Gln Ala Ser His His Leu Arg Val Tyr Glu Ser Val 
    130                 135                 140                 


Ala Gln Pro Ser Ile Gln Ala Ser Ser Thr Thr Val Thr Glu Lys Gly 
145                 150                 155                 160 


Ser Val Val Leu Thr Cys His Thr Asn Asn Thr Gly Thr Ser Phe Gln 
                165                 170                 175     


Trp Ile Phe Asn Asn Gln Arg Leu Gln Val Thr Lys Arg Met Lys Leu 
            180                 185                 190         


Ser Trp Phe Asn His Val Leu Thr Ile Asp Pro Ile Arg Gln Glu Asp 
        195                 200                 205             


Ala Gly Glu Tyr Gln Cys Glu Val Ser Asn Pro Val Ser Ser Asn Arg 
    210                 215                 220                 


Ser Asp Pro Leu Lys Leu Thr Val Lys Tyr Asp Asn Thr Leu Gly Ile 
225                 230                 235                 240 


Leu Ile Gly Val Leu Val Gly Ser Leu Leu Val Ala Ala Leu Val Cys 
                245                 250                 255     


Phe Leu Leu Leu Arg Lys Thr Gly Arg Ala Ser Asp Gln Ser Asp Phe 
            260                 265                 270         


Arg Glu Gln Gln Pro Pro Ala Ser Thr Pro Gly His Gly Pro Ser Asp 
        275                 280                 285             


Ser Ser Ile Ser 
    290         


<210>  5507
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  5507

Met Asn Ala Phe Leu Leu Ser Ala Leu Cys Leu Leu Gly Ala Trp Ala 
1               5                   10                  15      


Ala Leu Ala Gly Gly Val Thr Val Gln Asp Gly Asn Phe Ser Phe Ser 
            20                  25                  30          


Leu Glu Ser Val Lys Lys Leu Lys Asp Leu Gln Glu Pro Gln Glu Pro 
        35                  40                  45              


Arg Val Gly Lys Leu Arg Asn Phe Ala Pro Ile Pro Gly Glu Pro Val 
    50                  55                  60                  


Val Pro Ile Leu Cys Ser Asn Pro Asn Phe Pro Glu Glu Leu Lys Pro 
65                  70                  75                  80  


Leu Cys Lys Glu Pro Asn Ala Gln Glu Ile Leu Gln Arg Leu Glu Glu 
                85                  90                  95      


Ile Ala Glu Asp Pro Gly Thr Cys Glu Ile Cys Ala Tyr Ala Ala Cys 
            100                 105                 110         


Thr Gly Cys 
        115 


<210>  5508
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  5508

Met Pro Gly Ser Ala Ser Lys Arg Arg Ile Pro Val Ser Gln Pro Gly 
1               5                   10                  15      


Met Ala Asp Pro His Gln Leu Phe Asp Asp Thr Ser Ser Ala Gln Ser 
            20                  25                  30          


Arg Gly Tyr Gly Ala Gln Arg Ala Pro Gly Gly Leu Ser Tyr Pro Ala 
        35                  40                  45              


Ala Ser Pro Thr Pro His Ala Ala Phe Leu Ala Asp Pro Val Ser Asn 
    50                  55                  60                  


Met Ala Met Ala Tyr Gly Ser Ser Leu Ala Ala Gln Gly Lys Glu Leu 
65                  70                  75                  80  


Val Asp Lys Asn Ile Asp Arg Phe Ile Pro Ile Thr Lys Leu Lys Tyr 
                85                  90                  95      


Tyr Phe Ala Val Asp Thr Met Tyr Val Gly Arg Lys Leu Gly Leu Leu 
            100                 105                 110         


Phe Phe Pro Tyr Leu His Gln Asp Trp Glu Val Gln Tyr Gln Gln Asp 
        115                 120                 125             


Thr Pro Val Ala Pro Arg Phe Asp Val Asn Ala Pro Asp Leu Tyr Ile 
    130                 135                 140                 


Pro Ala Met Ala Phe Ile Thr Tyr Val Leu Val Ala Gly Leu Ala Leu 
145                 150                 155                 160 


Gly Thr Gln Asp Arg Phe Ser Pro Asp Leu Leu Gly Leu Gln Ala Ser 
                165                 170                 175     


Ser Ala Leu Ala Trp Leu Thr Leu Glu Val Leu Ala Ile Leu Leu Ser 
            180                 185                 190         


Leu Tyr Leu Val Thr Val Asn Thr Asp Leu Thr Thr Ile Asp Leu Val 
        195                 200                 205             


Ala Phe Leu Gly Tyr Lys Tyr Val Gly Met Ile Gly Gly Val Leu Met 
    210                 215                 220                 


Gly Leu Leu Phe Gly Lys Ile Gly Tyr Tyr Leu Val Leu Gly Trp Cys 
225                 230                 235                 240 


Cys Val Ala Ile Phe Val Phe Met Ile Arg Thr Leu Arg Leu Lys Ile 
                245                 250                 255     


Leu Ala Asp Ala Ala Ala Glu Gly Val Pro Val Arg Gly Ala Arg Asn 
            260                 265                 270         


Gln Leu Arg Met Tyr Leu Thr Met Ala Val Ala Ala Ala Gln Pro Met 
        275                 280                 285             


Leu Met Tyr Trp Leu Thr Phe His Leu Val Arg 
    290                 295                 


<210>  5509
<211>  707
<212>  PRT
<213>  Homo sapiens

<400>  5509

Met Asn Gln Glu Leu Leu Ser Val Gly Ser Lys Arg Arg Arg Thr Gly 
1               5                   10                  15      


Gly Ser Leu Arg Gly Asn Pro Ser Ser Ser Gln Val Asp Glu Glu Gln 
            20                  25                  30          


Met Asn Arg Val Val Glu Glu Glu Gln Gln Gln Gln Leu Arg Gln Gln 
        35                  40                  45              


Glu Glu Glu His Thr Ala Arg Asn Gly Glu Val Val Gly Val Glu Pro 
    50                  55                  60                  


Arg Pro Gly Gly Gln Asn Asp Ser Gln Gln Gly Gln Leu Glu Glu Asn 
65                  70                  75                  80  


Asn Asn Arg Phe Ile Ser Val Asp Glu Asp Ser Ser Gly Asn Gln Glu 
                85                  90                  95      


Glu Gln Glu Glu Asp Glu Glu His Ala Gly Glu Gln Asp Glu Glu Asp 
            100                 105                 110         


Glu Glu Glu Glu Glu Met Asp Gln Glu Ser Asp Asp Phe Asp Gln Ser 
        115                 120                 125             


Asp Asp Ser Ser Arg Glu Asp Glu His Thr His Thr Asn Ser Val Thr 
    130                 135                 140                 


Asn Ser Ser Ser Ile Val Asp Leu Pro Val His Gln Leu Ser Ser Pro 
145                 150                 155                 160 


Phe Tyr Thr Lys Thr Thr Lys Met Lys Arg Lys Leu Asp His Gly Ser 
                165                 170                 175     


Glu Val Arg Ser Phe Ser Leu Gly Lys Lys Pro Cys Lys Val Ser Glu 
            180                 185                 190         


Tyr Thr Ser Thr Thr Gly Leu Val Pro Cys Ser Ala Thr Pro Thr Thr 
        195                 200                 205             


Phe Gly Asp Leu Arg Ala Ala Asn Gly Gln Gly Gln Gln Arg Arg Arg 
    210                 215                 220                 


Ile Thr Ser Val Gln Pro Pro Thr Gly Leu Gln Glu Trp Leu Lys Met 
225                 230                 235                 240 


Phe Gln Ser Trp Ser Gly Pro Glu Lys Leu Leu Ala Leu Asp Glu Leu 
                245                 250                 255     


Ile Asp Ser Cys Glu Pro Thr Gln Val Lys His Met Met Gln Val Ile 
            260                 265                 270         


Glu Pro Gln Phe Gln Arg Asp Phe Ile Ser Leu Leu Pro Lys Glu Leu 
        275                 280                 285             


Ala Leu Tyr Val Leu Ser Phe Leu Glu Pro Lys Asp Leu Leu Gln Ala 
    290                 295                 300                 


Ala Gln Thr Cys Arg Tyr Trp Arg Ile Leu Ala Glu Asp Asn Leu Leu 
305                 310                 315                 320 


Trp Arg Glu Lys Cys Lys Glu Glu Gly Ile Asp Glu Pro Leu His Ile 
                325                 330                 335     


Lys Arg Arg Lys Val Ile Lys Pro Gly Phe Ile His Ser Pro Trp Lys 
            340                 345                 350         


Ser Ala Tyr Ile Arg Gln His Arg Ile Asp Thr Asn Trp Arg Arg Gly 
        355                 360                 365             


Glu Leu Lys Ser Pro Lys Val Leu Lys Gly His Asp Asp His Val Ile 
    370                 375                 380                 


Thr Cys Leu Gln Phe Cys Gly Asn Arg Ile Val Ser Gly Ser Asp Asp 
385                 390                 395                 400 


Asn Thr Leu Lys Val Trp Ser Ala Val Thr Gly Lys Cys Leu Arg Thr 
                405                 410                 415     


Leu Val Gly His Thr Gly Gly Val Trp Ser Ser Gln Met Arg Asp Asn 
            420                 425                 430         


Ile Ile Ile Ser Gly Ser Thr Asp Arg Thr Leu Lys Val Trp Asn Ala 
        435                 440                 445             


Glu Thr Gly Glu Cys Ile His Thr Leu Tyr Gly His Thr Ser Thr Val 
    450                 455                 460                 


Arg Cys Met His Leu His Glu Lys Arg Val Val Ser Gly Ser Arg Asp 
465                 470                 475                 480 


Ala Thr Leu Arg Val Trp Asp Ile Glu Thr Gly Gln Cys Leu His Val 
                485                 490                 495     


Leu Met Gly His Val Ala Ala Val Arg Cys Val Gln Tyr Asp Gly Arg 
            500                 505                 510         


Arg Val Val Ser Gly Ala Tyr Asp Phe Met Val Lys Val Trp Asp Pro 
        515                 520                 525             


Glu Thr Glu Thr Cys Leu His Thr Leu Gln Gly His Thr Asn Arg Val 
    530                 535                 540                 


Tyr Ser Leu Gln Phe Asp Gly Ile His Val Val Ser Gly Ser Leu Asp 
545                 550                 555                 560 


Thr Ser Ile Arg Val Trp Asp Val Glu Thr Gly Asn Cys Ile His Thr 
                565                 570                 575     


Leu Thr Gly His Gln Ser Leu Thr Ser Gly Met Glu Leu Lys Asp Asn 
            580                 585                 590         


Ile Leu Val Ser Gly Asn Ala Asp Ser Thr Val Lys Ile Trp Asp Ile 
        595                 600                 605             


Lys Thr Gly Gln Cys Leu Gln Thr Leu Gln Gly Pro Asn Lys His Gln 
    610                 615                 620                 


Ser Ala Val Thr Cys Leu Gln Phe Asn Lys Asn Phe Val Ile Thr Ser 
625                 630                 635                 640 


Ser Asp Asp Gly Thr Val Lys Leu Trp Asp Leu Lys Thr Gly Glu Phe 
                645                 650                 655     


Ile Arg Asn Leu Val Thr Leu Glu Ser Gly Gly Ser Gly Gly Val Val 
            660                 665                 670         


Trp Arg Ile Arg Ala Ser Asn Thr Lys Leu Val Cys Ala Val Gly Ser 
        675                 680                 685             


Arg Asn Gly Thr Glu Glu Thr Lys Leu Leu Val Leu Asp Phe Asp Val 
    690                 695                 700                 


Asp Met Lys 
705         


<210>  5510
<211>  785
<212>  PRT
<213>  Homo sapiens

<400>  5510

Met Lys Leu Gly Lys Val Glu Phe Cys His Phe Leu Gln Leu Ile Ala 
1               5                   10                  15      


Leu Phe Leu Cys Phe Ser Gly Met Ser Gln Ala Glu Leu Ser Arg Ser 
            20                  25                  30          


Arg Ser Lys Pro Tyr Phe Gln Ser Gly Arg Ser Arg Thr Lys Arg Ser 
        35                  40                  45              


Trp Val Trp Asn Gln Phe Phe Val Leu Glu Glu Tyr Met Gly Ser Asp 
    50                  55                  60                  


Pro Leu Tyr Val Gly Lys Leu His Ser Asp Val Asp Lys Gly Asp Gly 
65                  70                  75                  80  


Ser Ile Lys Tyr Ile Leu Ser Gly Glu Gly Ala Ser Ser Ile Phe Ile 
                85                  90                  95      


Ile Asp Glu Asn Thr Gly Asp Ile His Ala Thr Lys Arg Leu Asp Arg 
            100                 105                 110         


Glu Glu Gln Ala Tyr Tyr Thr Leu Arg Ala Gln Ala Leu Asp Arg Leu 
        115                 120                 125             


Thr Asn Lys Pro Val Glu Pro Glu Ser Glu Phe Val Ile Lys Ile Gln 
    130                 135                 140                 


Asp Ile Asn Asp Asn Glu Pro Lys Phe Leu Asp Gly Pro Tyr Thr Ala 
145                 150                 155                 160 


Gly Val Pro Glu Met Ser Pro Val Gly Thr Ser Val Val Gln Val Thr 
                165                 170                 175     


Ala Thr Asp Ala Asp Asp Pro Thr Tyr Gly Asn Ser Ala Arg Val Val 
            180                 185                 190         


Tyr Ser Ile Leu Gln Gly Gln Pro Tyr Phe Ser Val Glu Pro Lys Thr 
        195                 200                 205             


Gly Val Ile Lys Thr Ala Leu Pro Asn Met Asp Arg Glu Ala Lys Asp 
    210                 215                 220                 


Gln Tyr Leu Leu Val Ile Gln Ala Lys Asp Met Val Gly Gln Asn Gly 
225                 230                 235                 240 


Gly Leu Ser Gly Thr Thr Ser Val Thr Val Thr Leu Thr Asp Val Asn 
                245                 250                 255     


Asp Asn Pro Pro Arg Phe Pro Arg Arg Ser Tyr Gln Tyr Asn Val Pro 
            260                 265                 270         


Glu Ser Leu Pro Val Ala Ser Val Val Ala Arg Ile Lys Ala Ala Asp 
        275                 280                 285             


Ala Asp Ile Gly Ala Asn Ala Glu Met Glu Tyr Lys Ile Val Asp Gly 
    290                 295                 300                 


Asp Gly Leu Gly Ile Phe Lys Ile Ser Val Asp Lys Glu Thr Gln Glu 
305                 310                 315                 320 


Gly Ile Ile Thr Ile Gln Lys Glu Leu Asp Phe Glu Ala Lys Thr Ser 
                325                 330                 335     


Tyr Thr Leu Arg Ile Glu Ala Ala Asn Lys Asp Ala Asp Pro Arg Phe 
            340                 345                 350         


Leu Ser Leu Gly Pro Phe Ser Asp Thr Thr Thr Val Lys Ile Ile Val 
        355                 360                 365             


Glu Asp Val Asp Glu Pro Pro Val Phe Ser Ser Pro Leu Tyr Pro Met 
    370                 375                 380                 


Glu Val Ser Glu Ala Thr Gln Val Gly Asn Ile Ile Gly Thr Val Ala 
385                 390                 395                 400 


Ala His Asp Pro Asp Ser Ser Asn Ser Pro Val Arg Tyr Ser Ile Asp 
                405                 410                 415     


Arg Asn Thr Asp Leu Glu Arg Tyr Phe Asn Ile Asp Ala Asn Ser Gly 
            420                 425                 430         


Val Ile Thr Thr Ala Lys Ser Leu Asp Arg Glu Thr Asn Ala Ile His 
        435                 440                 445             


Asn Ile Thr Val Leu Ala Met Glu Ser Gln Asn Pro Ser Gln Val Gly 
    450                 455                 460                 


Arg Gly Tyr Val Ala Ile Thr Ile Leu Asp Ile Asn Asp Asn Ala Pro 
465                 470                 475                 480 


Glu Phe Ala Met Asp Tyr Glu Thr Thr Val Cys Glu Asn Ala Gln Pro 
                485                 490                 495     


Gly Gln Val Ile Gln Lys Ile Ser Ala Val Asp Lys Asp Glu Pro Ser 
            500                 505                 510         


Asn Gly His Gln Phe Tyr Phe Ser Leu Thr Thr Asp Ala Thr Asn Asn 
        515                 520                 525             


His Asn Phe Ser Leu Lys Asp Asn Lys Asp Asn Thr Ala Ser Ile Leu 
    530                 535                 540                 


Thr Arg Arg Asn Gly Phe Arg Arg Gln Glu Gln Ser Val Tyr Tyr Leu 
545                 550                 555                 560 


Pro Ile Phe Ile Val Asp Ser Gly Ser Pro Ser Leu Ser Ser Thr Asn 
                565                 570                 575     


Thr Leu Thr Ile Arg Val Cys Asp Cys Asp Ala Asp Gly Val Ala Gln 
            580                 585                 590         


Thr Cys Asn Ala Glu Ala Tyr Val Leu Pro Ala Gly Leu Ser Thr Gly 
        595                 600                 605             


Ala Leu Ile Ala Ile Leu Ala Cys Val Leu Thr Leu Leu Val Leu Ile 
    610                 615                 620                 


Leu Leu Ile Val Thr Met Arg Arg Arg Lys Lys Glu Pro Leu Ile Phe 
625                 630                 635                 640 


Asp Glu Glu Arg Asp Ile Arg Glu Asn Ile Val Arg Tyr Asp Asp Glu 
                645                 650                 655     


Gly Gly Gly Glu Glu Asp Thr Glu Ala Phe Asp Met Ala Ala Leu Arg 
            660                 665                 670         


Asn Leu Asn Val Ile Arg Asp Thr Lys Thr Arg Arg Asp Val Thr Pro 
        675                 680                 685             


Glu Ile Gln Phe Leu Ser Arg Pro Ala Phe Lys Ser Ile Pro Asp Asn 
    690                 695                 700                 


Val Ile Phe Arg Glu Phe Ile Trp Glu Arg Leu Lys Glu Ala Asp Val 
705                 710                 715                 720 


Asp Pro Gly Ala Pro Pro Tyr Asp Ser Leu Gln Thr Tyr Ala Phe Glu 
                725                 730                 735     


Gly Asn Gly Ser Val Ala Glu Ser Leu Ser Ser Leu Asp Ser Ile Ser 
            740                 745                 750         


Ser Asn Ser Asp Gln Asn Tyr Asp Tyr Leu Ser Asp Trp Gly Pro Arg 
        755                 760                 765             


Phe Lys Arg Leu Ala Asp Met Tyr Gly Thr Gly Gln Glu Ser Leu Tyr 
    770                 775                 780                 


Ser 
785 


<210>  5511
<211>  367
<212>  PRT
<213>  Homo sapiens

<400>  5511

Met Ala Ser Leu Ser Gln Leu Ser Gly His Leu Asn Tyr Thr Cys Gly 
1               5                   10                  15      


Ala Glu Asn Ser Thr Gly Ala Ser Gln Ala Arg Pro His Ala Tyr Tyr 
            20                  25                  30          


Ala Leu Ser Tyr Cys Ala Leu Ile Leu Ala Ile Val Phe Gly Asn Gly 
        35                  40                  45              


Leu Val Cys Met Ala Val Leu Lys Glu Arg Ala Leu Gln Thr Thr Thr 
    50                  55                  60                  


Asn Tyr Leu Val Val Ser Leu Ala Val Ala Asp Leu Leu Val Ala Thr 
65                  70                  75                  80  


Leu Val Met Pro Trp Val Val Tyr Leu Glu Val Thr Gly Gly Val Trp 
                85                  90                  95      


Asn Phe Ser Arg Ile Cys Cys Asp Val Phe Val Thr Leu Asp Val Met 
            100                 105                 110         


Met Cys Thr Ala Ser Ile Leu Asn Leu Cys Ala Ile Ser Ile Asp Arg 
        115                 120                 125             


Tyr Thr Ala Val Val Met Pro Val His Tyr Gln His Gly Thr Gly Gln 
    130                 135                 140                 


Ser Ser Cys Arg Arg Val Ala Leu Met Ile Thr Ala Val Trp Val Leu 
145                 150                 155                 160 


Ala Phe Ala Val Ser Cys Pro Leu Leu Phe Gly Phe Asn Thr Thr Gly 
                165                 170                 175     


Asp Pro Thr Val Cys Ser Ile Ser Asn Pro Asp Phe Val Ile Tyr Ser 
            180                 185                 190         


Ser Val Val Ser Phe Tyr Leu Pro Phe Gly Val Thr Val Leu Val Tyr 
        195                 200                 205             


Ala Arg Ile Tyr Val Val Leu Lys Gln Arg Arg Arg Lys Arg Ile Leu 
    210                 215                 220                 


Thr Arg Gln Asn Ser Gln Cys Asn Ser Val Arg Pro Gly Phe Pro Gln 
225                 230                 235                 240 


Gln Thr Leu Ser Pro Asp Pro Ala His Leu Glu Leu Lys Arg Tyr Tyr 
                245                 250                 255     


Ser Ile Cys Gln Asp Thr Ala Leu Gly Gly Pro Gly Phe Gln Glu Arg 
            260                 265                 270         


Gly Gly Glu Leu Lys Arg Glu Glu Lys Thr Arg Asn Ser Leu Met Pro 
        275                 280                 285             


Leu Arg Glu Lys Lys Ala Thr Gln Met Val Ala Ile Val Leu Gly Ala 
    290                 295                 300                 


Phe Ile Val Cys Trp Leu Pro Phe Phe Leu Thr His Val Leu Asn Thr 
305                 310                 315                 320 


His Cys Gln Thr Cys His Val Ser Pro Glu Leu Tyr Ser Ala Thr Thr 
                325                 330                 335     


Trp Leu Gly Tyr Val Asn Ser Ala Leu Asn Pro Val Ile Tyr Thr Thr 
            340                 345                 350         


Phe Asn Ile Glu Phe Arg Lys Ala Phe Leu Lys Ile Leu Ser Cys 
        355                 360                 365         


<210>  5512
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  5512

Met Glu Leu Leu Glu Glu Asp Leu Thr Cys Pro Ile Cys Cys Ser Leu 
1               5                   10                  15      


Phe Asp Asp Pro Arg Val Leu Pro Cys Ser His Asn Phe Cys Lys Lys 
            20                  25                  30          


Cys Leu Glu Gly Ile Leu Glu Gly Ser Val Arg Asn Ser Leu Trp Arg 
        35                  40                  45              


Pro Ala Pro Phe Lys Cys Pro Thr Cys Arg Lys Glu Thr Ser Ala Thr 
    50                  55                  60                  


Gly Ile Asn Ser Leu Gln Val Asn Tyr Ser Leu Lys Gly Ile Val Glu 
65                  70                  75                  80  


Lys Tyr Asn Lys Ile Lys Ile Ser Pro Lys Met Pro Val Cys Lys Gly 
                85                  90                  95      


His Leu Gly Gln Pro Leu Asn Ile Phe Cys Leu Thr Asp Met Gln Leu 
            100                 105                 110         


Ile Cys Gly Ile Cys Ala Thr Arg Gly Glu His Thr Lys His Val Phe 
        115                 120                 125             


Cys Ser Ile Glu Asp Ala Tyr Ala Gln Glu Arg Asp Ala Phe Glu Ser 
    130                 135                 140                 


Leu Phe Gln Ser Phe Glu Thr Trp Arg Arg Gly Asp Ala Leu Ser Arg 
145                 150                 155                 160 


Leu Asp Thr Leu Glu Thr Ser Lys Arg Lys Ser Leu Gln Leu Leu Thr 
                165                 170                 175     


Lys Asp Ser Asp Lys Val Lys Glu Phe Phe Glu Lys Leu Gln His Thr 
            180                 185                 190         


Leu Asp Gln Lys Lys Asn Glu Ile Leu Ser Asp Phe Glu Thr Met Lys 
        195                 200                 205             


Leu Ala Val Met Gln Ala Tyr Asp Pro Glu Ile Asn Lys Leu Asn Thr 
    210                 215                 220                 


Ile Leu Gln Glu Gln Arg Met Ala Phe Asn Ile Ala Glu Ala Phe Lys 
225                 230                 235                 240 


Asp Val Ser Glu Pro Ile Val Phe Leu Gln Gln Met Gln Glu Phe Arg 
                245                 250                 255     


Glu Lys Ile Lys Val Ile Lys Glu Thr Pro Leu Pro Pro Ser Asn Leu 
            260                 265                 270         


Pro Ala Ser Pro Leu Met Lys Asn Phe Asp Thr Ser Gln Trp Glu Asp 
        275                 280                 285             


Ile Lys Leu Val Asp Val Asp Lys Leu Ser Leu Pro Gln Asp Thr Gly 
    290                 295                 300                 


Thr Phe Ile Ser Lys Ile Pro Trp Ser Phe Tyr Lys Leu Phe Leu Leu 
305                 310                 315                 320 


Ile Leu Leu Leu Gly Leu Val Ile Val Phe Gly Pro Thr Met Phe Leu 
                325                 330                 335     


Glu Trp Ser Leu Phe Asp Asp Leu Ala Thr Trp Lys Gly Cys Leu Ser 
            340                 345                 350         


Asn Phe Ser Ser Tyr Leu Thr Lys Thr Ala Asp Phe Ile Glu Gln Ser 
        355                 360                 365             


Val Phe Tyr Trp Glu Gln Val Thr Asp Gly Phe Phe Ile Phe Asn Glu 
    370                 375                 380                 


Arg Phe Lys Asn Phe Thr Leu Val Val Leu Asn Asn Val Ala Glu Phe 
385                 390                 395                 400 


Val Cys Lys Tyr Lys Leu Leu 
                405         


<210>  5513
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  5513

Met Glu Ala Leu Gly Asp Leu Glu Gly Pro Arg Ala Pro Gly Gly Asp 
1               5                   10                  15      


Asp Pro Ala Gly Ser Ala Gly Glu Thr Pro Gly Trp Leu Ser Arg Glu 
            20                  25                  30          


Gln Val Phe Val Leu Ile Ser Ala Ala Ser Val Asn Leu Gly Ser Met 
        35                  40                  45              


Met Cys Tyr Ser Ile Leu Gly Pro Phe Phe Pro Lys Glu Ala Glu Lys 
    50                  55                  60                  


Lys Gly Ala Ser Asn Thr Ile Ile Gly Met Ile Phe Gly Cys Phe Ala 
65                  70                  75                  80  


Leu Phe Glu Leu Leu Ala Ser Leu Val Phe Gly Asn Tyr Leu Val His 
                85                  90                  95      


Ile Gly Ala Lys Phe Met Phe Val Ala Gly Met Phe Val Ser Gly Gly 
            100                 105                 110         


Val Thr Ile Leu Phe Gly Val Leu Asp Arg Val Pro Asp Gly Pro Val 
        115                 120                 125             


Phe Ile Ala Met Cys Phe Leu Val Arg Val Met Asp Ala Val Ser Phe 
    130                 135                 140                 


Ala Ala Ala Met Thr Ala Ser Ser Ser Ile Leu Ala Lys Ala Phe Pro 
145                 150                 155                 160 


Asn Asn Val Ala Thr Val Leu Gly Ser Leu Glu Thr Phe Ser Gly Leu 
                165                 170                 175     


Gly Leu Ile Leu Gly Pro Pro Val Gly Gly Phe Leu Tyr Gln Ser Phe 
            180                 185                 190         


Gly Tyr Glu Val Pro Phe Ile Val Leu Gly Cys Val Val Leu Leu Met 
        195                 200                 205             


Val Pro Leu Asn Met Tyr Ile Leu Pro Asn Tyr Glu Ser Asp Pro Gly 
    210                 215                 220                 


Glu His Ser Phe Trp Lys Leu Ile Ala Leu Pro Lys Val Gly Leu Ile 
225                 230                 235                 240 


Ala Phe Val Ile Asn Ser Leu Ser Ser Cys Phe Gly Phe Leu Asp Pro 
                245                 250                 255     


Thr Leu Ser Leu Phe Val Leu Glu Lys Phe Asn Leu Pro Ala Gly Tyr 
            260                 265                 270         


Val Gly Leu Val Phe Leu Gly Met Ala Leu Ser Tyr Ala Ile Ser Ser 
        275                 280                 285             


Pro Leu Phe Gly Leu Leu Ser Asp Lys Arg Pro Pro Leu Arg Lys Trp 
    290                 295                 300                 


Leu Leu Val Phe Gly Asn Leu Ile Thr Ala Gly Cys Tyr Met Leu Leu 
305                 310                 315                 320 


Gly Pro Val Pro Ile Leu His Ile Lys Ser Gln Leu Trp Leu Leu Val 
                325                 330                 335     


Leu Ile Leu Val Val Ser Gly Leu Ser Ala Gly Met Ser Ile Ile Pro 
            340                 345                 350         


Thr Phe Pro Glu Ile Leu Ser Cys Ala His Glu Asn Gly Phe Glu Glu 
        355                 360                 365             


Gly Leu Ser Thr Leu Gly Leu Val Ser Gly Leu Phe Ser Ala Met Trp 
    370                 375                 380                 


Ser Ile Gly Ala Phe Met Gly Pro Thr Leu Gly Gly Phe Leu Tyr Glu 
385                 390                 395                 400 


Lys Ile Gly Phe Glu Trp Ala Ala Ala Ile Gln Gly Leu Trp Ala Leu 
                405                 410                 415     


Ile Ser Gly Leu Ala Met Gly Leu Phe Tyr Leu Leu Glu Tyr Ser Arg 
            420                 425                 430         


Arg Lys Arg Ser Lys Ser Gln Asn Ile Leu Ser Thr Glu Glu Glu Arg 
        435                 440                 445             


Thr Thr Leu Leu Pro Asn Glu Thr 
    450                 455     


<210>  5514
<211>  656
<212>  PRT
<213>  Homo sapiens

<400>  5514

Met Thr Gly Ala Lys Arg Lys Lys Lys Ser Met Leu Trp Ser Lys Met 
1               5                   10                  15      


His Thr Pro Gln Cys Glu Asp Ile Ile Gln Trp Cys Arg Arg Arg Leu 
            20                  25                  30          


Pro Ile Leu Asp Trp Ala Pro His Tyr Asn Leu Lys Glu Asn Leu Leu 
        35                  40                  45              


Pro Asp Thr Val Ser Gly Ile Met Leu Ala Val Gln Gln Val Thr Gln 
    50                  55                  60                  


Gly Leu Ala Phe Ala Val Leu Ser Ser Val His Pro Val Phe Gly Leu 
65                  70                  75                  80  


Tyr Gly Ser Leu Phe Pro Ala Ile Ile Tyr Ala Ile Phe Gly Met Gly 
                85                  90                  95      


His His Val Ala Thr Gly Thr Phe Ala Leu Thr Ser Leu Ile Ser Ala 
            100                 105                 110         


Asn Ala Val Glu Arg Ile Val Pro Gln Asn Met Gln Asn Leu Thr Thr 
        115                 120                 125             


Gln Ser Asn Thr Ser Val Leu Gly Leu Ser Asp Phe Glu Met Gln Arg 
    130                 135                 140                 


Ile His Val Ala Ala Ala Val Ser Phe Leu Gly Gly Val Ile Gln Val 
145                 150                 155                 160 


Ala Met Phe Val Leu Gln Leu Gly Ser Ala Thr Phe Val Val Thr Glu 
                165                 170                 175     


Pro Val Ile Ser Ala Met Thr Thr Gly Ala Ala Thr His Val Val Thr 
            180                 185                 190         


Ser Gln Val Lys Tyr Leu Leu Gly Met Lys Met Pro Tyr Ile Ser Gly 
        195                 200                 205             


Pro Leu Gly Phe Phe Tyr Ile Tyr Ala Tyr Val Phe Glu Asn Ile Lys 
    210                 215                 220                 


Ser Val Arg Leu Glu Ala Leu Leu Leu Ser Leu Leu Ser Ile Val Val 
225                 230                 235                 240 


Leu Val Leu Val Lys Glu Leu Asn Glu Gln Phe Lys Arg Lys Ile Lys 
                245                 250                 255     


Val Val Leu Pro Val Asp Leu Val Leu Ile Ile Ala Ala Ser Phe Ala 
            260                 265                 270         


Cys Tyr Cys Thr Asn Met Glu Asn Thr Tyr Gly Leu Glu Val Val Gly 
        275                 280                 285             


His Ile Pro Gln Gly Ile Pro Ser Pro Arg Ala Pro Pro Met Asn Ile 
    290                 295                 300                 


Leu Ser Ala Val Ile Thr Glu Ala Phe Gly Val Ala Leu Val Gly Tyr 
305                 310                 315                 320 


Val Ala Ser Leu Ala Leu Ala Gln Gly Ser Ala Lys Lys Phe Lys Tyr 
                325                 330                 335     


Ser Ile Asp Asp Asn Gln Glu Phe Leu Ala His Gly Leu Ser Asn Ile 
            340                 345                 350         


Val Ser Ser Phe Phe Phe Cys Ile Pro Ser Ala Ala Ala Met Gly Arg 
        355                 360                 365             


Thr Ala Gly Leu Tyr Ser Thr Gly Ala Lys Thr Gln Val Ala Cys Leu 
    370                 375                 380                 


Ile Ser Cys Ile Phe Val Leu Ile Val Ile Tyr Ala Ile Gly Pro Leu 
385                 390                 395                 400 


Leu Tyr Trp Leu Pro Met Cys Val Leu Ala Ser Ile Ile Val Val Gly 
                405                 410                 415     


Leu Lys Gly Met Leu Ile Gln Phe Arg Asp Leu Lys Lys Tyr Trp Asn 
            420                 425                 430         


Val Asp Lys Ile Asp Trp Gly Ile Trp Val Ser Thr Tyr Val Phe Thr 
        435                 440                 445             


Ile Cys Phe Ala Ala Asn Val Gly Leu Leu Phe Gly Val Val Cys Thr 
    450                 455                 460                 


Ile Ala Ile Val Ile Gly Arg Phe Pro Arg Ala Met Thr Val Ser Ile 
465                 470                 475                 480 


Lys Asn Met Lys Glu Met Glu Phe Lys Val Lys Thr Glu Met Asp Ser 
                485                 490                 495     


Glu Thr Leu Gln Gln Val Lys Ile Ile Ser Ile Asn Asn Pro Leu Val 
            500                 505                 510         


Phe Leu Asn Ala Lys Lys Phe Tyr Thr Asp Leu Met Asn Met Ile Gln 
        515                 520                 525             


Lys Glu Asn Ala Cys Asn Gln Pro Leu Asp Asp Ile Ser Lys Cys Glu 
    530                 535                 540                 


Gln Asn Thr Leu Leu Asn Ser Leu Ser Asn Gly Asn Cys Asn Glu Glu 
545                 550                 555                 560 


Ala Ser Gln Ser Cys Pro Asn Glu Lys Cys Tyr Leu Ile Leu Asp Cys 
                565                 570                 575     


Ser Gly Phe Thr Phe Phe Asp Tyr Ser Gly Val Ser Met Leu Val Glu 
            580                 585                 590         


Val Tyr Met Asp Cys Lys Gly Arg Ser Val Asp Val Leu Leu Ala His 
        595                 600                 605             


Cys Thr Ala Ser Leu Ile Lys Ala Met Thr Tyr Tyr Gly Asn Leu Asp 
    610                 615                 620                 


Ser Glu Lys Pro Ile Phe Phe Glu Ser Val Ser Ala Ala Ile Ser His 
625                 630                 635                 640 


Ile His Ser Asn Lys Asn Leu Ser Lys Leu Ser Asp His Ser Glu Val 
                645                 650                 655     


<210>  5515
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  5515

Met Gly Arg His Val Ala Thr Ser Cys His Val Ala Trp Leu Leu Val 
1               5                   10                  15      


Leu Ile Ser Gly Cys Trp Gly Gln Val Asn Arg Leu Pro Phe Phe Thr 
            20                  25                  30          


Asn His Phe Phe Asp Thr Tyr Leu Leu Ile Ser Glu Asp Thr Pro Val 
        35                  40                  45              


Gly Ser Ser Val Thr Gln Leu Leu Ala Gln Asp Met Asp Asn Asp Pro 
    50                  55                  60                  


Leu Val Phe Gly Val Ser Gly Glu Glu Ala Ser Arg Phe Phe Ala Val 
65                  70                  75                  80  


Glu Pro Asp Thr Gly Val Val Trp Leu Arg Gln Pro Leu Asp Arg Glu 
                85                  90                  95      


Thr Lys Ser Glu Phe Thr Val Glu Phe Ser Val Ser Asp His Gln Gly 
            100                 105                 110         


Val Ile Thr Arg Lys Val Asn Ile Gln Val Gly Asp Val Asn Asp Asn 
        115                 120                 125             


Ala Pro Thr Phe His Asn Gln Pro Tyr Ser Val Arg Ile Pro Glu Asn 
    130                 135                 140                 


Thr Pro Val Gly Thr Pro Ile Phe Ile Val Asn Ala Thr Asp Pro Asp 
145                 150                 155                 160 


Leu Gly Ala Gly Gly Ser Val Leu Tyr Ser Phe Gln Pro Pro Ser Gln 
                165                 170                 175     


Phe Phe Ala Ile Asp Ser Ala Arg Gly Ile Val Thr Val Ile Arg Glu 
            180                 185                 190         


Leu Asp Tyr Glu Thr Thr Gln Ala Tyr Gln Leu Thr Val Asn Ala Thr 
        195                 200                 205             


Asp Gln Asp Lys Thr Arg Pro Leu Ser Thr Leu Ala Asn Leu Ala Ile 
    210                 215                 220                 


Ile Ile Thr Asp Val Gln Asp Met Asp Pro Ile Phe Ile Asn Leu Pro 
225                 230                 235                 240 


Tyr Ser Thr Asn Ile Tyr Glu His Ser Pro Pro Gly Thr Thr Val Arg 
                245                 250                 255     


Ile Ile Thr Ala Ile Asp Gln Asp Lys Gly Arg Pro Arg Gly Ile Gly 
            260                 265                 270         


Tyr Thr Ile Val Ser Gly Asn Thr Asn Ser Ile Phe Ala Leu Asp Tyr 
        275                 280                 285             


Ile Ser Gly Val Leu Thr Leu Asn Gly Leu Leu Asp Arg Glu Asn Pro 
    290                 295                 300                 


Leu Tyr Ser His Gly Phe Ile Leu Thr Val Lys Gly Thr Glu Leu Asn 
305                 310                 315                 320 


Asp Asp Arg Thr Pro Ser Asp Ala Thr Val Thr Thr Thr Phe Asn Ile 
                325                 330                 335     


Leu Val Ile Asp Ile Asn Asp Asn Ala Pro Glu Phe Asn Ser Ser Glu 
            340                 345                 350         


Tyr Ser Val Ala Ile Thr Glu Leu Ala Gln Val Gly Phe Ala Leu Pro 
        355                 360                 365             


Leu Phe Ile Gln Val Val Asp Lys Asp Glu Asn Leu Gly Leu Asn Ser 
    370                 375                 380                 


Met Phe Glu Val Tyr Leu Val Gly Asn Asn Ser His His Phe Ile Ile 
385                 390                 395                 400 


Ser Pro Thr Ser Val Gln Gly Lys Ala Asp Ile Arg Ile Arg Val Ala 
                405                 410                 415     


Ile Pro Leu Asp Tyr Glu Thr Val Asp Arg Tyr Asp Phe Asp Leu Phe 
            420                 425                 430         


Ala Asn Glu Ser Val Pro Asp His Val Gly Tyr Ala Lys Val Lys Ile 
        435                 440                 445             


Thr Leu Ile Asn Glu Asn Asp Asn Arg Pro Ile Phe Ser Gln Pro Leu 
    450                 455                 460                 


Tyr Asn Ile Ser Leu Tyr Glu Asn Val Thr Val Gly Thr Ser Val Leu 
465                 470                 475                 480 


Thr Val Leu Val Ser Pro Arg Phe Thr Ala Gly Pro Leu Ser Ser Pro 
                485                 490                 495     


Gly Pro Thr Val Val Arg His Pro Glu Gly Phe Cys Pro Arg Asp Leu 
            500                 505                 510         


Ser Asn Gln Gly Arg Arg His Pro Gln Ile Pro Glu Leu Cys Leu Leu 
        515                 520                 525             


Val Tyr 
    530 


<210>  5516
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  5516

Met Ala Gln Ser Arg Asp Gly Gly Asn Pro Phe Ala Glu Pro Ser Glu 
1               5                   10                  15      


Leu Asp Asn Pro Phe Gln Pro Pro Pro Ala Tyr Glu Pro Pro Ala Pro 
            20                  25                  30          


Ala Pro Leu Pro Pro Pro Ser Ala Pro Ser Leu Gln Pro Ser Arg Lys 
        35                  40                  45              


Leu Ser Pro Thr Glu Pro Lys Asn Tyr Gly Ser Tyr Ser Thr Gln Ala 
    50                  55                  60                  


Ser Ala Ala Ala Ala Thr Ala Glu Leu Leu Lys Lys Gln Glu Glu Leu 
65                  70                  75                  80  


Asn Arg Lys Ala Glu Glu Leu Asp Arg Arg Glu Arg Glu Leu Gln His 
                85                  90                  95      


Ala Ala Leu Gly Gly Thr Ala Thr Arg Gln Asn Asn Trp Pro Pro Leu 
            100                 105                 110         


Pro Ser Phe Cys Pro Val Gln Pro Cys Phe Phe Gln Asp Ile Ser Met 
        115                 120                 125             


Glu Ile Pro Gln Glu Phe Gln Lys Thr Val Ser Thr Met Tyr Tyr Leu 
    130                 135                 140                 


Trp Met Cys Ser Thr Leu Ala Leu Leu Leu Asn Phe Leu Ala Cys Leu 
145                 150                 155                 160 


Ala Ser Phe Cys Val Glu Thr Asn Asn Gly Ala Gly Phe Gly Leu Ser 
                165                 170                 175     


Ile Leu Trp Val Leu Leu Phe Thr Pro Cys Ser Phe Val Cys Trp Tyr 
            180                 185                 190         


Arg Pro Met Tyr Lys Ala Phe Arg Ser Asp Ser Ser Phe Asn Phe Phe 
        195                 200                 205             


Val Phe Phe Phe Ile Phe Phe Val Gln Asp Val Leu Phe Val Leu Gln 
    210                 215                 220                 


Ala Ile Gly Ile Pro Gly Trp Gly Phe Ser Gly Trp Ile Ser Ala Leu 
225                 230                 235                 240 


Val Val Pro Lys Gly Asn Thr Ala Val Ser Val Leu Met Leu Leu Val 
                245                 250                 255     


Ala Leu Leu Phe Thr Gly Ile Ala Val Leu Gly Ile Val Met Leu Lys 
            260                 265                 270         


Arg Ile His Ser Leu Tyr Arg Arg Thr Gly Ala Ser Phe Gln Lys Ala 
        275                 280                 285             


Gln Gln Glu Phe Ala Ala Gly Val Phe Ser Asn Pro Ala Val Arg Thr 
    290                 295                 300                 


Ala Ala Ala Asn Ala Ala Ala Gly Ala Ala Glu Asn Ala Phe Arg Ala 
305                 310                 315                 320 


Pro 
    


<210>  5517
<211>  677
<212>  PRT
<213>  Homo sapiens

<400>  5517

Met His His Leu Leu Glu Gln Ser Ala Asp Met Ala Thr Ala Leu Leu 
1               5                   10                  15      


Ala Gly Glu Lys Leu Arg Glu Leu Ile Leu Pro Gly Ala Gln Asp Asp 
            20                  25                  30          


Lys Ala Gly Ala Leu Ala Ala Leu Leu Leu Gln Leu Lys Leu Glu Leu 
        35                  40                  45              


Pro Phe Asp Arg Val Val Thr Ile Gly Thr Val Leu Val Pro Ile Leu 
    50                  55                  60                  


Leu Val Thr Leu Val Phe Thr Lys Asn Phe Ala Glu Glu Pro Ile Tyr 
65                  70                  75                  80  


Cys Tyr Thr Pro His Asn Phe Thr Arg Asp Gln Ala Leu Tyr Ala Arg 
                85                  90                  95      


Gly Tyr Cys Trp Thr Glu Leu Arg Asp Ala Leu Pro Gly Val Asp Ala 
            100                 105                 110         


Ser Leu Trp Pro Ser Leu Phe Glu His Lys Phe Leu Pro Tyr Ala Leu 
        115                 120                 125             


Leu Ala Phe Ala Ala Ile Met Tyr Val Pro Ala Leu Gly Trp Glu Phe 
    130                 135                 140                 


Leu Ala Ser Thr Arg Leu Thr Ser Glu Leu Asn Phe Leu Leu Gln Glu 
145                 150                 155                 160 


Ile Asp Asn Cys Tyr His Arg Ala Ala Glu Gly Arg Ala Pro Lys Ile 
                165                 170                 175     


Glu Lys Gln Ile Gln Ser Lys Gly Pro Gly Ile Thr Glu Arg Glu Lys 
            180                 185                 190         


Arg Glu Ile Ile Glu Asn Ala Glu Lys Glu Lys Ser Pro Glu Gln Asn 
        195                 200                 205             


Leu Phe Glu Lys Tyr Leu Glu Arg Arg Gly Arg Ser Asn Phe Leu Ala 
    210                 215                 220                 


Lys Leu Tyr Leu Ala Arg His Val Leu Ile Leu Leu Leu Ser Ala Val 
225                 230                 235                 240 


Pro Ile Ser Tyr Leu Cys Thr Tyr Tyr Ala Thr Gln Lys Gln Asn Glu 
                245                 250                 255     


Phe Thr Cys Ala Leu Gly Ala Ser Pro Asp Gly Ala Ala Gly Ala Gly 
            260                 265                 270         


Pro Ala Val Arg Val Ser Cys Lys Leu Pro Ser Val Gln Leu Gln Arg 
        275                 280                 285             


Ile Ile Ala Gly Val Asp Ile Val Leu Leu Cys Val Met Asn Leu Ile 
    290                 295                 300                 


Ile Leu Val Asn Leu Ile His Leu Phe Ile Phe Arg Lys Ser Asn Phe 
305                 310                 315                 320 


Ile Phe Asp Lys Leu His Lys Val Gly Ile Lys Thr Arg Arg Gln Trp 
                325                 330                 335     


Arg Arg Ser Gln Phe Cys Asp Ile Asn Ile Leu Ala Met Phe Cys Asn 
            340                 345                 350         


Glu Asn Arg Asp His Ile Lys Ser Leu Asn Arg Leu Asp Phe Ile Thr 
        355                 360                 365             


Asn Glu Ser Asp Leu Met Tyr Asp Asn Val Val Arg Gln Leu Leu Ala 
    370                 375                 380                 


Ala Leu Ala Gln Ser Asn His Asp Ala Thr Pro Thr Val Arg Asp Ser 
385                 390                 395                 400 


Gly Val Gln Thr Val Asp Pro Ser Ala Asn Pro Ala Glu Pro Asp Gly 
                405                 410                 415     


Ala Ala Glu Pro Pro Val Val Lys Arg Pro Arg Lys Lys Met Lys Trp 
            420                 425                 430         


Ile Pro Thr Ser Asn Pro Leu Pro Gln Pro Phe Lys Glu Pro Leu Ala 
        435                 440                 445             


Ile Met Arg Val Glu Asn Ser Lys Ala Glu Lys Pro Lys Pro Ala Arg 
    450                 455                 460                 


Arg Lys Thr Ala Thr Asp Thr Leu Ile Ala Pro Leu Leu Asp Arg Ser 
465                 470                 475                 480 


Ala His His Tyr Lys Gly Gly Gly Gly Asp Pro Gly Pro Gly Pro Ala 
                485                 490                 495     


Pro Ala Pro Ala Pro Pro Pro Ala Pro Asp Lys Lys His Ala Arg His 
            500                 505                 510         


Phe Ser Leu Asp Val His Pro Tyr Ile Leu Gly Thr Lys Lys Ala Lys 
        515                 520                 525             


Ala Glu Ala Val Pro Ala Ala Leu Pro Ala Ser Arg Ser Gln Glu Gly 
    530                 535                 540                 


Gly Phe Leu Ser Gln Ala Glu Asp Cys Gly Leu Gly Leu Ala Pro Ala 
545                 550                 555                 560 


Pro Ile Lys Asp Ala Pro Leu Pro Glu Lys Glu Ile Pro Tyr Pro Thr 
                565                 570                 575     


Glu Pro Ala Arg Ala Gly Leu Pro Ser Gly Gly Pro Phe His Val Arg 
            580                 585                 590         


Ser Pro Pro Ala Ala Pro Ala Val Ala Pro Leu Thr Pro Ala Ser Leu 
        595                 600                 605             


Gly Lys Ala Glu Pro Leu Thr Ile Leu Ser Arg Asn Ala Thr His Pro 
    610                 615                 620                 


Leu Leu His Ile Asn Thr Leu Tyr Glu Ala Arg Glu Glu Glu Asp Gly 
625                 630                 635                 640 


Gly Pro Arg Leu Pro Gln Asp Val Gly Asp Leu Ile Ala Ile Pro Ala 
                645                 650                 655     


Pro Gln Gln Ile Leu Ile Ala Thr Phe Asp Glu Pro Arg Thr Val Val 
            660                 665                 670         


Ser Thr Val Glu Phe 
        675         


<210>  5518
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  5518

Met Glu Asp Pro Ser Gly Ala Arg Glu Pro Arg Ala Arg Pro Arg Glu 
1               5                   10                  15      


Arg Asp Pro Gly Arg Arg Pro His Pro Asp Gln Gly Arg Thr His Asp 
            20                  25                  30          


Arg Pro Arg Asp Arg Pro Gly Asp Pro Arg Arg Lys Arg Ser Ser Asp 
        35                  40                  45              


Gly Asn Arg Arg Arg Asp Gly Asp Arg Asp Pro Glu Arg Asp Gln Glu 
    50                  55                  60                  


Arg Asp Gly Asn Arg Asp Arg Asn Arg Asp Arg Glu Arg Glu Arg Glu 
65                  70                  75                  80  


Arg Glu Arg Asp Pro Asp Arg Gly Pro Arg Arg Asp Thr His Arg Asp 
                85                  90                  95      


Ala Gly Pro Arg Ala Gly Glu His Gly Val Trp Glu Lys Pro Arg Gln 
            100                 105                 110         


Ser Arg Thr Arg Asp Gly Ala Arg Gly Leu Thr Trp Asp Ala Ala Ala 
        115                 120                 125             


Pro Pro Gly Pro Ala Pro Trp Glu Ala Pro Glu Pro Pro Gln Pro Gln 
    130                 135                 140                 


Arg Lys Gly Asp Pro Gly Arg Arg Arg Pro Glu Ser Glu Pro Pro Ser 
145                 150                 155                 160 


Glu Arg Tyr Leu Pro Ser Thr Pro Arg Pro Gly Arg Glu Glu Val Glu 
                165                 170                 175     


Tyr Tyr Gln Ser Glu Ala Glu Gly Leu Leu Glu Cys His Lys Cys Lys 
            180                 185                 190         


Tyr Leu Cys Thr Gly Arg Ala Cys Cys Gln Met Leu Glu Val Leu Leu 
        195                 200                 205             


Asn Leu Leu Ile Leu Ala Cys Ser Ser Val Ser Tyr Ser Ser Thr Gly 
    210                 215                 220                 


Gly Tyr Thr Gly Ile Thr Ser Leu Gly Gly Ile Tyr Tyr Tyr Gln Phe 
225                 230                 235                 240 


Gly Gly Ala Tyr Ser Gly Phe Asp Gly Ala Asp Gly Glu Lys Ala Gln 
                245                 250                 255     


Gln Leu Asp Val Gln Phe Tyr Gln Leu Lys Leu Pro Met Val Thr Val 
            260                 265                 270         


Ala Met Ala Cys Ser Gly Ala Leu Thr Ala Leu Cys Cys Leu Phe Val 
        275                 280                 285             


Ala Met Gly Val Leu Arg Val Pro Trp His Cys Pro Leu Leu Leu Val 
    290                 295                 300                 


Thr Glu Gly Leu Leu Asp Met Leu Ile Ala Gly Gly Tyr Ile Pro Ala 
305                 310                 315                 320 


Leu Tyr Phe Tyr Phe His Tyr Leu Ser Ala Ala Tyr Gly Ser Pro Val 
                325                 330                 335     


Cys Lys Glu Arg Gln Ala Leu Tyr Gln Ser Lys Gly Tyr Ser Gly Phe 
            340                 345                 350         


Gly Cys Ser Phe His Gly Ala Asp Ile Gly Ala Gly Ile Phe Ala Ala 
        355                 360                 365             


Leu Gly Ile Val Val Phe Ala Leu Gly Ala Val Leu Ala Ile Lys Gly 
    370                 375                 380                 


Tyr Arg Lys Val Arg Lys Leu Lys Glu Lys Pro Ala Glu Met Phe Glu 
385                 390                 395                 400 


Phe 
    


<210>  5519
<211>  541
<212>  PRT
<213>  Homo sapiens

<400>  5519

Met Gly Ser Gln Glu Val Leu Gly His Ala Ala Arg Leu Ala Ser Ser 
1               5                   10                  15      


Gly Leu Leu Leu Gln Val Leu Phe Arg Leu Ile Thr Phe Val Leu Asn 
            20                  25                  30          


Ala Phe Ile Leu Arg Phe Leu Ser Lys Glu Ile Val Gly Val Val Asn 
        35                  40                  45              


Val Arg Leu Thr Leu Leu Tyr Ser Thr Thr Leu Phe Leu Ala Arg Glu 
    50                  55                  60                  


Ala Phe Arg Arg Ala Cys Leu Ser Gly Gly Thr Gln Arg Asp Trp Ser 
65                  70                  75                  80  


Gln Thr Leu Asn Leu Leu Trp Leu Thr Val Pro Leu Gly Val Phe Trp 
                85                  90                  95      


Ser Leu Phe Leu Gly Trp Ile Trp Leu Gln Leu Leu Glu Val Pro Asp 
            100                 105                 110         


Pro Asn Val Val Pro His Tyr Ala Thr Gly Val Val Leu Phe Gly Leu 
        115                 120                 125             


Ser Ala Val Val Glu Leu Leu Gly Glu Pro Phe Trp Val Leu Ala Gln 
    130                 135                 140                 


Ala His Met Phe Val Lys Leu Lys Val Ile Ala Glu Ser Leu Ser Val 
145                 150                 155                 160 


Ile Leu Lys Ser Val Leu Thr Ala Phe Leu Val Leu Trp Leu Pro His 
                165                 170                 175     


Trp Gly Leu Tyr Ile Phe Ser Leu Ala Gln Leu Phe Tyr Thr Thr Val 
            180                 185                 190         


Leu Val Leu Cys Tyr Val Ile Tyr Phe Thr Lys Leu Leu Gly Ser Pro 
        195                 200                 205             


Glu Ser Thr Lys Leu Gln Thr Leu Pro Val Ser Arg Ile Thr Asp Leu 
    210                 215                 220                 


Leu Pro Asn Ile Thr Arg Asn Gly Ala Phe Ile Asn Trp Lys Glu Ala 
225                 230                 235                 240 


Lys Leu Thr Trp Ser Phe Phe Lys Gln Ser Phe Leu Lys Gln Ile Leu 
                245                 250                 255     


Thr Glu Gly Glu Arg Tyr Val Met Thr Phe Leu Asn Val Leu Asn Phe 
            260                 265                 270         


Gly Asp Gln Gly Val Tyr Asp Ile Val Asn Asn Leu Gly Ser Leu Val 
        275                 280                 285             


Ala Arg Leu Ile Phe Gln Pro Ile Glu Glu Ser Phe Tyr Ile Phe Phe 
    290                 295                 300                 


Ala Lys Val Leu Glu Arg Gly Lys Asp Ala Thr Leu Gln Lys Gln Glu 
305                 310                 315                 320 


Asp Val Ala Val Ala Ala Ala Val Leu Glu Ser Leu Leu Lys Leu Ala 
                325                 330                 335     


Leu Leu Ala Gly Leu Thr Ile Thr Val Phe Gly Phe Ala Tyr Ser Gln 
            340                 345                 350         


Leu Ala Leu Asp Ile Tyr Gly Gly Thr Met Leu Ser Ser Gly Ser Gly 
        355                 360                 365             


Pro Val Leu Leu Arg Ser Tyr Cys Leu Tyr Val Leu Leu Leu Ala Ile 
    370                 375                 380                 


Asn Gly Val Thr Glu Cys Phe Thr Phe Ala Ala Met Ser Lys Glu Glu 
385                 390                 395                 400 


Val Asp Arg Tyr Asn Phe Val Met Leu Ala Leu Ser Ser Ser Phe Leu 
                405                 410                 415     


Val Leu Ser Tyr Leu Leu Thr Arg Trp Cys Gly Ser Val Gly Phe Ile 
            420                 425                 430         


Leu Ala Asn Cys Phe Asn Met Gly Ile Arg Ile Thr Gln Ser Leu Cys 
        435                 440                 445             


Phe Ile His Arg Tyr Tyr Arg Arg Ser Pro His Arg Pro Leu Ala Gly 
    450                 455                 460                 


Leu His Leu Ser Pro Val Leu Leu Gly Thr Phe Ala Leu Ser Gly Gly 
465                 470                 475                 480 


Val Thr Ala Val Ser Glu Val Phe Leu Cys Cys Glu Gln Gly Trp Pro 
                485                 490                 495     


Ala Arg Leu Ala His Ile Ala Val Gly Ala Phe Cys Leu Gly Ala Thr 
            500                 505                 510         


Leu Gly Thr Ala Phe Leu Thr Glu Thr Lys Leu Ile His Phe Leu Arg 
        515                 520                 525             


Thr Gln Leu Gly Val Pro Arg Arg Thr Asp Lys Met Thr 
    530                 535                 540     


<210>  5520
<211>  1738
<212>  PRT
<213>  Homo sapiens

<400>  5520

Met Leu Lys Arg Lys Gln Ser Ser Arg Val Glu Ala Gln Pro Val Thr 
1               5                   10                  15      


Asp Phe Gly Pro Asp Glu Ser Leu Ser Asp Asn Ala Asp Ile Leu Trp 
            20                  25                  30          


Ile Asn Lys Pro Trp Val His Ser Leu Leu Arg Ile Cys Ala Ile Ile 
        35                  40                  45              


Ser Val Ile Ser Val Cys Met Asn Thr Pro Met Thr Phe Glu His Tyr 
    50                  55                  60                  


Pro Pro Leu Gln Tyr Val Thr Phe Thr Leu Asp Thr Leu Leu Met Phe 
65                  70                  75                  80  


Leu Tyr Thr Ala Glu Met Ile Ala Lys Met His Ile Arg Gly Ile Val 
                85                  90                  95      


Lys Gly Asp Ser Ser Tyr Val Lys Asp Arg Trp Cys Val Phe Asp Gly 
            100                 105                 110         


Phe Met Val Phe Cys Leu Trp Val Ser Leu Val Leu Gln Val Phe Glu 
        115                 120                 125             


Ile Ala Asp Ile Val Asp Gln Met Ser Pro Trp Gly Met Leu Arg Ile 
    130                 135                 140                 


Pro Arg Pro Leu Ile Met Ile Arg Ala Phe Arg Ile Tyr Phe Arg Phe 
145                 150                 155                 160 


Glu Leu Pro Arg Thr Arg Ile Thr Asn Ile Leu Lys Arg Ser Gly Glu 
                165                 170                 175     


Gln Ile Trp Ser Val Ser Ile Phe Leu Leu Phe Phe Leu Leu Leu Tyr 
            180                 185                 190         


Gly Ile Leu Gly Val Gln Met Phe Gly Thr Phe Thr Tyr His Cys Val 
        195                 200                 205             


Val Asn Asp Thr Lys Pro Gly Asn Val Thr Trp Asn Ser Leu Ala Ile 
    210                 215                 220                 


Pro Asp Thr His Cys Ser Pro Glu Leu Glu Glu Gly Tyr Gln Cys Pro 
225                 230                 235                 240 


Pro Gly Phe Lys Cys Met Asp Leu Glu Asp Leu Gly Leu Ser Arg Gln 
                245                 250                 255     


Glu Leu Gly Tyr Ser Gly Phe Asn Glu Ile Gly Thr Ser Ile Phe Thr 
            260                 265                 270         


Val Tyr Glu Ala Ala Ser Gln Glu Gly Trp Val Phe Leu Met Tyr Arg 
        275                 280                 285             


Ala Ile Asp Ser Phe Pro Arg Trp Arg Ser Tyr Phe Tyr Phe Ile Thr 
    290                 295                 300                 


Leu Ile Phe Phe Leu Ala Trp Leu Val Lys Asn Val Phe Ile Ala Val 
305                 310                 315                 320 


Ile Ile Glu Thr Phe Ala Glu Ile Arg Val Gln Phe Gln Gln Met Trp 
                325                 330                 335     


Gly Ser Arg Ser Ser Thr Thr Ser Thr Ala Thr Thr Gln Met Phe His 
            340                 345                 350         


Glu Asp Ala Ala Gly Gly Trp Gln Leu Val Ala Val Asp Val Asn Lys 
        355                 360                 365             


Pro Gln Gly Arg Ala Pro Ala Cys Leu Gln Lys Met Met Arg Ser Ser 
    370                 375                 380                 


Val Phe His Met Phe Ile Leu Ser Met Val Thr Val Asp Val Ile Val 
385                 390                 395                 400 


Ala Ala Ser Asn Tyr Tyr Lys Gly Glu Asn Phe Arg Arg Gln Tyr Asp 
                405                 410                 415     


Glu Phe Tyr Leu Ala Glu Val Ala Phe Thr Val Leu Phe Asp Leu Glu 
            420                 425                 430         


Ala Leu Leu Lys Ile Trp Cys Leu Gly Phe Thr Gly Tyr Ile Ser Ser 
        435                 440                 445             


Ser Leu His Lys Phe Glu Leu Leu Leu Val Ile Gly Thr Thr Leu His 
    450                 455                 460                 


Val Tyr Pro Asp Leu Tyr His Ser Gln Phe Thr Tyr Phe Gln Val Leu 
465                 470                 475                 480 


Arg Val Val Arg Leu Ile Lys Ile Ser Pro Ala Leu Glu Asp Phe Val 
                485                 490                 495     


Tyr Lys Ile Phe Gly Pro Gly Lys Lys Leu Gly Ser Leu Val Val Phe 
            500                 505                 510         


Thr Ala Ser Leu Leu Ile Val Met Ser Ala Ile Ser Leu Gln Met Phe 
        515                 520                 525             


Cys Phe Val Glu Glu Leu Asp Arg Phe Thr Thr Phe Pro Arg Ala Phe 
    530                 535                 540                 


Met Ser Met Phe Gln Ile Leu Thr Gln Glu Gly Trp Val Asp Val Met 
545                 550                 555                 560 


Asp Gln Thr Leu Asn Ala Val Gly His Met Trp Ala Pro Val Val Ala 
                565                 570                 575     


Ile Tyr Phe Ile Leu Tyr His Leu Phe Ala Thr Leu Ile Leu Leu Ser 
            580                 585                 590         


Leu Phe Val Ala Val Ile Leu Asp Asn Leu Glu Leu Asp Glu Asp Leu 
        595                 600                 605             


Lys Lys Leu Lys Gln Leu Lys Gln Ser Glu Ala Asn Ala Asp Thr Lys 
    610                 615                 620                 


Glu Lys Leu Pro Leu Arg Leu Arg Ile Phe Glu Lys Phe Pro Asn Arg 
625                 630                 635                 640 


Pro Gln Met Val Lys Ile Ser Lys Leu Pro Ser Asp Phe Thr Val Pro 
                645                 650                 655     


Lys Ile Arg Glu Ser Phe Met Lys Gln Phe Ile Asp Arg Gln Gln Gln 
            660                 665                 670         


Asp Thr Cys Cys Leu Leu Arg Ser Leu Pro Thr Thr Ser Ser Ser Ser 
        675                 680                 685             


Cys Asp His Ser Lys Arg Ser Ala Ile Glu Asp Asn Lys Tyr Ile Asp 
    690                 695                 700                 


Gln Lys Leu Arg Lys Ser Val Phe Ser Ile Arg Ala Arg Asn Leu Leu 
705                 710                 715                 720 


Glu Lys Glu Thr Ala Val Thr Lys Ile Leu Arg Ala Cys Thr Arg Gln 
                725                 730                 735     


Arg Met Leu Ser Gly Ser Phe Glu Gly Gln Pro Ala Lys Glu Arg Ser 
            740                 745                 750         


Ile Leu Ser Val Gln His His Ile Arg Gln Glu Arg Arg Ser Leu Arg 
        755                 760                 765             


His Gly Ser Asn Ser Gln Arg Ile Ser Arg Gly Lys Ser Leu Glu Thr 
    770                 775                 780                 


Leu Thr Gln Asp His Ser Asn Thr Val Arg Tyr Arg Asn Ala Gln Arg 
785                 790                 795                 800 


Glu Asp Ser Glu Ile Lys Met Ile Gln Glu Lys Lys Glu Gln Ala Glu 
                805                 810                 815     


Met Lys Arg Lys Val Gln Glu Glu Glu Leu Arg Glu Asn His Pro Tyr 
            820                 825                 830         


Phe Asp Lys Pro Leu Phe Ile Val Gly Arg Glu His Arg Phe Arg Asn 
        835                 840                 845             


Phe Cys Arg Val Val Val Arg Ala Arg Phe Asn Ala Ser Lys Thr Asp 
    850                 855                 860                 


Pro Val Thr Gly Ala Val Lys Asn Thr Lys Tyr His Gln Leu Tyr Asp 
865                 870                 875                 880 


Leu Leu Gly Leu Val Thr Tyr Leu Asp Trp Val Met Ile Ile Val Thr 
                885                 890                 895     


Ile Cys Ser Cys Ile Ser Met Met Phe Glu Ser Pro Phe Arg Arg Val 
            900                 905                 910         


Met His Ala Pro Thr Leu Gln Ile Ala Glu Tyr Val Phe Val Ile Phe 
        915                 920                 925             


Met Ser Ile Glu Leu Asn Leu Lys Ile Met Ala Asp Gly Leu Phe Phe 
    930                 935                 940                 


Thr Pro Thr Ala Val Ile Arg Asp Phe Gly Gly Val Met Asp Ile Phe 
945                 950                 955                 960 


Ile Tyr Leu Val Ser Leu Ile Phe Leu Cys Trp Met Pro Gln Asn Val 
                965                 970                 975     


Pro Ala Glu Ser Gly Ala Gln Leu Leu Met Val Leu Arg Cys Leu Arg 
            980                 985                 990         


Pro Leu Arg Ile Phe Lys Leu Val  Pro Gln Met Arg Lys  Val Val Arg 
        995                 1000                 1005             


Glu Leu  Phe Ser Gly Phe Lys  Glu Ile Phe Leu Val  Ser Ile Leu 
    1010                 1015                 1020             


Leu Leu  Thr Leu Met Leu Val  Phe Ala Ser Phe Gly  Val Gln Leu 
    1025                 1030                 1035             


Phe Ala  Gly Lys Leu Ala Lys  Cys Asn Asp Pro Asn  Ile Ile Arg 
    1040                 1045                 1050             


Arg Glu  Asp Cys Asn Gly Ile  Phe Arg Ile Asn Val  Ser Val Ser 
    1055                 1060                 1065             


Lys Asn  Leu Asn Leu Lys Leu  Arg Pro Gly Glu Lys  Lys Pro Gly 
    1070                 1075                 1080             


Phe Trp  Val Pro Arg Val Trp  Ala Asn Pro Arg Asn  Phe Asn Phe 
    1085                 1090                 1095             


Asp Asn  Val Gly Asn Ala Met  Leu Ala Leu Phe Glu  Val Leu Ser 
    1100                 1105                 1110             


Leu Lys  Gly Trp Val Glu Val  Arg Asp Val Ile Ile  His Arg Val 
    1115                 1120                 1125             


Gly Pro  Ile His Gly Ile Tyr  Ile His Val Phe Val  Phe Leu Gly 
    1130                 1135                 1140             


Cys Met  Ile Gly Leu Thr Leu  Phe Val Gly Val Val  Ile Ala Asn 
    1145                 1150                 1155             


Phe Asn  Glu Asn Lys Gly Thr  Ala Leu Leu Thr Val  Asp Gln Arg 
    1160                 1165                 1170             


Arg Trp  Glu Asp Leu Lys Ser  Arg Leu Lys Ile Ala  Gln Pro Leu 
    1175                 1180                 1185             


His Leu  Pro Pro Arg Pro Asp  Asn Asp Gly Phe Arg  Ala Lys Met 
    1190                 1195                 1200             


Tyr Asp  Ile Thr Gln His Pro  Phe Phe Lys Arg Thr  Ile Ala Leu 
    1205                 1210                 1215             


Leu Val  Leu Ala Gln Ser Val  Leu Leu Ser Val Lys  Trp Asp Val 
    1220                 1225                 1230             


Glu Asp  Pro Val Thr Val Pro  Leu Ala Thr Met Ser  Val Val Phe 
    1235                 1240                 1245             


Thr Phe  Ile Phe Val Leu Glu  Val Thr Met Lys Ile  Ile Ala Met 
    1250                 1255                 1260             


Ser Pro  Ala Gly Phe Trp Gln  Ser Arg Arg Asn Arg  Tyr Asp Leu 
    1265                 1270                 1275             


Leu Val  Thr Ser Leu Gly Val  Val Trp Val Val Leu  His Phe Ala 
    1280                 1285                 1290             


Leu Leu  Asn Ala Tyr Thr Tyr  Met Met Gly Ala Cys  Val Ile Val 
    1295                 1300                 1305             


Phe Arg  Phe Phe Ser Ile Cys  Gly Lys His Val Thr  Leu Lys Met 
    1310                 1315                 1320             


Leu Leu  Leu Thr Val Val Val  Ser Met Tyr Lys Ser  Phe Phe Ile 
    1325                 1330                 1335             


Ile Val  Gly Met Phe Leu Leu  Leu Leu Cys Tyr Ala  Phe Ala Gly 
    1340                 1345                 1350             


Val Val  Leu Phe Gly Thr Val  Lys Tyr Gly Glu Asn  Ile Asn Arg 
    1355                 1360                 1365             


His Ala  Asn Phe Ser Ser Ala  Gly Lys Ala Ile Thr  Val Leu Phe 
    1370                 1375                 1380             


Arg Ile  Val Thr Gly Glu Asp  Trp Asn Lys Ile Met  His Asp Cys 
    1385                 1390                 1395             


Met Val  Gln Pro Pro Phe Cys  Thr Pro Asp Glu Phe  Thr Tyr Trp 
    1400                 1405                 1410             


Ala Thr  Asp Cys Gly Asn Tyr  Ala Gly Ala Leu Met  Tyr Phe Cys 
    1415                 1420                 1425             


Ser Phe  Tyr Val Ile Ile Ala  Tyr Ile Met Leu Asn  Leu Leu Val 
    1430                 1435                 1440             


Ala Ile  Ile Val Glu Asn Phe  Ser Leu Phe Tyr Ser  Thr Glu Glu 
    1445                 1450                 1455             


Asp Gln  Leu Leu Ser Tyr Asn  Asp Leu Arg His Phe  Gln Ile Ile 
    1460                 1465                 1470             


Trp Asn  Met Val Asp Asp Lys  Arg Glu Gly Val Ile  Pro Thr Phe 
    1475                 1480                 1485             


Arg Val  Lys Phe Leu Leu Arg  Leu Leu Arg Gly Arg  Leu Glu Val 
    1490                 1495                 1500             


Asp Leu  Asp Lys Asp Lys Leu  Leu Phe Lys His Met  Cys Tyr Glu 
    1505                 1510                 1515             


Met Glu  Arg Leu His Asn Gly  Gly Asp Val Thr Phe  His Asp Val 
    1520                 1525                 1530             


Leu Ser  Met Leu Ser Tyr Arg  Ser Val Asp Ile Arg  Lys Ser Leu 
    1535                 1540                 1545             


Gln Leu  Glu Glu Leu Leu Ala  Arg Glu Gln Leu Glu  Tyr Thr Ile 
    1550                 1555                 1560             


Glu Glu  Glu Val Ala Lys Gln  Thr Ile Arg Met Trp  Leu Lys Lys 
    1565                 1570                 1575             


Cys Leu  Lys Arg Ile Arg Ala  Lys Gln Gln Gln Ser  Cys Ser Ile 
    1580                 1585                 1590             


Ile His  Ser Leu Arg Glu Ser  Gln Gln Gln Glu Leu  Ser Arg Phe 
    1595                 1600                 1605             


Leu Asn  Pro Pro Ser Ile Glu  Thr Thr Gln Pro Ser  Glu Asp Thr 
    1610                 1615                 1620             


Asn Ala  Asn Ser Gln Asp Asn  Ser Met Gln Pro Glu  Thr Ser Ser 
    1625                 1630                 1635             


Gln Gln  Gln Leu Leu Ser Pro  Thr Leu Ser Asp Arg  Gly Gly Ser 
    1640                 1645                 1650             


Arg Gln  Asp Ala Ala Asp Ala  Gly Lys Pro Gln Arg  Lys Phe Gly 
    1655                 1660                 1665             


Gln Trp  Arg Leu Pro Ser Ala  Pro Lys Pro Ile Ser  His Ser Val 
    1670                 1675                 1680             


Ser Ser  Val Asn Leu Arg Phe  Gly Gly Arg Thr Thr  Met Lys Ser 
    1685                 1690                 1695             


Val Val  Cys Lys Met Asn Pro  Met Thr Asp Ala Ala  Ser Cys Gly 
    1700                 1705                 1710             


Ser Glu  Val Lys Lys Trp Trp  Thr Arg Gln Leu Thr  Val Glu Ser 
    1715                 1720                 1725             


Asp Glu  Ser Gly Asp Asp Leu  Leu Asp Ile 
    1730                 1735             


<210>  5521
<211>  613
<212>  PRT
<213>  Homo sapiens

<400>  5521

Met Gly Ala Leu Arg Pro Thr Leu Leu Pro Pro Ser Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Met Leu Gly Met Gly Cys Trp Ala Arg Glu Val Leu Val 
            20                  25                  30          


Pro Glu Gly Pro Leu Tyr Arg Val Ala Gly Thr Ala Val Ser Ile Ser 
        35                  40                  45              


Cys Asn Val Thr Gly Tyr Glu Gly Pro Ala Gln Gln Asn Phe Glu Trp 
    50                  55                  60                  


Phe Leu Tyr Arg Pro Glu Ala Pro Asp Thr Ala Leu Gly Ile Val Ser 
65                  70                  75                  80  


Thr Lys Asp Thr Gln Phe Ser Tyr Ala Val Phe Lys Ser Arg Val Val 
                85                  90                  95      


Ala Gly Glu Val Gln Val Gln Arg Leu Gln Gly Asp Ala Val Val Leu 
            100                 105                 110         


Lys Ile Ala Arg Leu Gln Ala Gln Asp Ala Gly Ile Tyr Glu Cys His 
        115                 120                 125             


Thr Pro Ser Thr Asp Thr Arg Tyr Leu Gly Ser Tyr Ser Gly Lys Val 
    130                 135                 140                 


Glu Leu Arg Val Leu Pro Asp Val Leu Gln Val Ser Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Pro Arg Gly Arg Gln Ala Pro Thr Ser Pro Pro Arg Met Thr Val 
                165                 170                 175     


His Glu Gly Gln Glu Leu Ala Leu Gly Cys Leu Ala Arg Thr Ser Thr 
            180                 185                 190         


Gln Lys His Thr His Leu Ala Val Ser Phe Gly Arg Ser Val Pro Glu 
        195                 200                 205             


Ala Pro Val Gly Arg Ser Thr Leu Gln Glu Val Val Gly Ile Arg Ser 
    210                 215                 220                 


Asp Leu Ala Val Glu Ala Gly Ala Pro Tyr Ala Glu Arg Leu Ala Ala 
225                 230                 235                 240 


Gly Glu Leu Arg Leu Gly Lys Glu Gly Thr Asp Arg Tyr Arg Met Val 
                245                 250                 255     


Val Gly Gly Ala Gln Ala Gly Asp Ala Gly Thr Tyr His Cys Thr Ala 
            260                 265                 270         


Ala Glu Trp Ile Gln Asp Pro Asp Gly Ser Trp Ala Gln Ile Ala Glu 
        275                 280                 285             


Lys Arg Ala Val Leu Ala His Val Asp Val Gln Thr Leu Ser Ser Gln 
    290                 295                 300                 


Leu Ala Val Thr Val Gly Pro Gly Glu Arg Arg Ile Gly Pro Gly Glu 
305                 310                 315                 320 


Pro Leu Glu Leu Leu Cys Asn Val Ser Gly Ala Leu Pro Pro Ala Gly 
                325                 330                 335     


Arg His Ala Ala Tyr Ser Val Gly Trp Glu Met Ala Pro Ala Gly Ala 
            340                 345                 350         


Pro Gly Pro Gly Arg Leu Val Ala Gln Leu Asp Thr Glu Gly Val Gly 
        355                 360                 365             


Ser Leu Gly Pro Gly Tyr Glu Gly Arg His Ile Ala Met Glu Lys Val 
    370                 375                 380                 


Ala Ser Arg Thr Tyr Arg Leu Arg Leu Glu Ala Ala Arg Pro Gly Asp 
385                 390                 395                 400 


Ala Gly Thr Tyr Arg Cys Leu Ala Lys Ala Tyr Val Arg Gly Ser Gly 
                405                 410                 415     


Thr Arg Leu Arg Glu Ala Ala Ser Ala Arg Ser Arg Pro Leu Pro Val 
            420                 425                 430         


His Val Arg Glu Glu Gly Val Val Leu Glu Ala Val Ala Trp Leu Ala 
        435                 440                 445             


Gly Gly Thr Val Tyr Arg Gly Glu Thr Ala Ser Leu Leu Cys Asn Ile 
    450                 455                 460                 


Ser Val Arg Gly Gly Pro Pro Gly Leu Arg Leu Ala Ala Ser Trp Trp 
465                 470                 475                 480 


Val Glu Arg Pro Glu Asp Gly Glu Leu Ser Ser Val Pro Ala Gln Leu 
                485                 490                 495     


Val Gly Gly Val Gly Gln Asp Gly Val Ala Glu Leu Gly Val Arg Pro 
            500                 505                 510         


Gly Gly Gly Pro Val Ser Val Glu Leu Val Gly Pro Arg Ser His Arg 
        515                 520                 525             


Leu Arg Leu His Ser Leu Gly Pro Glu Asp Glu Gly Val Tyr His Cys 
    530                 535                 540                 


Ala Pro Ser Ala Trp Val Gln His Ala Asp Tyr Ser Trp Tyr Gln Ala 
545                 550                 555                 560 


Gly Ser Ala Arg Ser Gly Pro Val Thr Val Tyr Pro Tyr Met His Ala 
                565                 570                 575     


Leu Asp Thr Leu Phe Val Pro Leu Leu Val Gly Thr Gly Val Ala Leu 
            580                 585                 590         


Val Thr Gly Ala Thr Val Leu Gly Thr Ile Thr Cys Cys Phe Met Lys 
        595                 600                 605             


Arg Leu Arg Lys Arg 
    610             


<210>  5522
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  5522

Met Gln Ile Gln Val Ala Gly Leu Leu Gln Phe Ala Val Pro Leu Phe 
1               5                   10                  15      


Ser Thr Ala Glu Glu Asp Leu Leu Ala Ile Gln Leu Leu Leu Asn Ser 
            20                  25                  30          


Ser Glu Ser Ser Leu His Gln Leu Thr Ala Met Val Asp Cys Arg Gly 
        35                  40                  45              


Leu His Lys Asp Tyr Leu Asp Ala Leu Ala Gly Ile Cys Tyr Asp Gly 
    50                  55                  60                  


Leu Gln Gly Leu Leu Tyr Leu Gly Leu Phe Ser Phe Leu Ala Ala Leu 
65                  70                  75                  80  


Ala Phe Ser Thr Met Ile Cys Ala Gly Pro Arg Ala Trp Lys His Phe 
                85                  90                  95      


Thr Thr Arg Asn Arg Asp Tyr Asp Asp Ile Asp Asp Asp Asp Pro Phe 
            100                 105                 110         


Asn Pro Gln Ala Trp Arg Met Ala Ala His Ser Pro Pro Arg Gly Gln 
        115                 120                 125             


Leu His Ser Phe Cys Ser Tyr Ser Ser Gly Leu Gly Ser Gln Thr Ser 
    130                 135                 140                 


Leu Gln Pro Pro Ala Gln Thr Ile Ser Asn Ala Pro Val Ser Glu Tyr 
145                 150                 155                 160 


Met Asn Gln Ala Met Leu Phe Gly Arg Asn Pro Arg Tyr Glu Asn Val 
                165                 170                 175     


Pro Leu Ile Gly Arg Ala Ser Pro Pro Pro Thr Tyr Ser Pro Ser Met 
            180                 185                 190         


Arg Ala Thr Tyr Leu Ser Val Ala Asp Glu His Leu Arg His Tyr Gly 
        195                 200                 205             


Asn Gln Phe Pro Ala 
    210             


<210>  5523
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  5523

Met Lys Asp Arg Thr Gln Glu Leu Arg Ser Ala Lys Asp Ser Asp Asp 
1               5                   10                  15      


Glu Glu Glu Val Val His Val Asp Arg Asp His Phe Met Asp Glu Phe 
            20                  25                  30          


Phe Glu Gln Val Glu Glu Ile Arg Gly Cys Ile Glu Lys Leu Ser Glu 
        35                  40                  45              


Asp Val Glu Gln Val Lys Lys Gln His Ser Ala Ile Leu Ala Ala Pro 
    50                  55                  60                  


Asn Pro Asp Glu Lys Thr Lys Gln Glu Leu Glu Asp Leu Thr Ala Asp 
65                  70                  75                  80  


Ile Lys Lys Thr Ala Asn Lys Val Arg Ser Lys Leu Lys Ala Ile Glu 
                85                  90                  95      


Gln Ser Ile Glu Gln Glu Glu Gly Leu Asn Arg Ser Ser Ala Asp Leu 
            100                 105                 110         


Arg Ile Arg Lys Thr Gln His Ser Thr Leu Ser Arg Lys Phe Val Glu 
        115                 120                 125             


Val Met Thr Glu Tyr Asn Ala Thr Gln Ser Lys Tyr Arg Asp Arg Cys 
    130                 135                 140                 


Lys Asp Arg Ile Gln Arg Gln Leu Glu Ile Thr Gly Arg Thr Thr Thr 
145                 150                 155                 160 


Asn Glu Glu Leu Glu Asp Met Leu Glu Ser Gly Lys Leu Ala Ile Phe 
                165                 170                 175     


Thr Asp Asp Ile Lys Met Asp Ser Gln Met Thr Lys Gln Ala Leu Asn 
            180                 185                 190         


Glu Ile Glu Thr Arg His Asn Glu Ile Ile Lys Leu Glu Thr Ser Ile 
        195                 200                 205             


Arg Glu Leu His Asp Met Phe Val Asp Met Ala Met Leu Val Glu Ser 
    210                 215                 220                 


Gln Gly Glu Met Ile Asp Arg Ile Glu Tyr Asn Val Glu His Ser Val 
225                 230                 235                 240 


Asp Tyr Val Glu Arg Ala Val Ser Asp Thr Lys Lys Ala Val Lys Tyr 
                245                 250                 255     


Gln Ser Lys Ala Arg Arg Lys Lys Ile Met Ile Ile Ile Cys Cys Val 
            260                 265                 270         


Val Leu Gly Val Val Leu Ala Ser Ser Ile Gly Gly Thr Leu Gly Leu 
        275                 280                 285             


<210>  5524
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  5524

Met Leu Leu Ala Trp Val Gln Ala Phe Leu Val Ser Asn Met Leu Leu 
1               5                   10                  15      


Ala Glu Ala Tyr Gly Ser Gly Gly Cys Phe Trp Asp Asn Gly His Leu 
            20                  25                  30          


Tyr Arg Glu Asp Gln Thr Ser Pro Ala Pro Gly Leu Arg Cys Leu Asn 
        35                  40                  45              


Trp Leu Asp Ala Gln Ser Gly Leu Ala Ser Ala Pro Val Ser Gly Ala 
    50                  55                  60                  


Gly Asn His Ser Tyr Cys Arg Asn Pro Asp Glu Asp Pro Arg Gly Pro 
65                  70                  75                  80  


Trp Cys Tyr Val Ser Gly Glu Ala Gly Val Pro Glu Lys Arg Pro Cys 
                85                  90                  95      


Glu Asp Leu Arg Cys Pro Glu Thr Thr Ser Gln Ala Leu Pro Ala Phe 
            100                 105                 110         


Thr Thr Glu Ile Gln Glu Ala Ser Glu Gly Pro Gly Ala Asp Glu Val 
        115                 120                 125             


Gln Val Phe Ala Pro Ala Asn Ala Leu Pro Ala Arg Ser Glu Ala Ala 
    130                 135                 140                 


Ala Val Gln Pro Val Ile Gly Ile Ser Gln Arg Val Arg Met Asn Ser 
145                 150                 155                 160 


Lys Glu Lys Lys Asp Leu Gly Thr Leu Gly Tyr Val Leu Gly Ile Thr 
                165                 170                 175     


Met Met Val Ile Ile Ile Ala Ile Gly Ala Gly Ile Ile Leu Gly Tyr 
            180                 185                 190         


Ser Tyr Lys Arg Gly Lys Asp Leu Lys Glu Gln His Asp Gln Lys Val 
        195                 200                 205             


Cys Glu Arg Glu Met Gln Arg Ile Thr Leu Pro Leu Ser Ala Phe Thr 
    210                 215                 220                 


Asn Pro Thr Cys Glu Ile Val Asp Glu Lys Thr Val Val Val His Thr 
225                 230                 235                 240 


Ser Gln Thr Pro Val Asp Pro Gln Glu Gly Thr Thr Pro Leu Met Gly 
                245                 250                 255     


Gln Ala Gly Thr Pro Gly Ala 
            260             


<210>  5525
<211>  698
<212>  PRT
<213>  Homo sapiens

<400>  5525

Met Val Pro Gly Gln Ala Gln Pro Gln Ser Pro Glu Met Leu Leu Leu 
1               5                   10                  15      


Pro Leu Leu Leu Pro Val Leu Gly Ala Gly Ser Leu Asn Lys Asp Pro 
            20                  25                  30          


Ser Tyr Ser Leu Gln Val Gln Arg Gln Val Pro Val Pro Glu Gly Leu 
        35                  40                  45              


Cys Val Ile Val Ser Cys Asn Leu Ser Tyr Pro Arg Asp Gly Trp Asp 
    50                  55                  60                  


Glu Ser Thr Ala Ala Tyr Gly Tyr Trp Phe Lys Gly Arg Thr Ser Pro 
65                  70                  75                  80  


Lys Thr Gly Ala Pro Val Ala Thr Asn Asn Gln Ser Arg Glu Val Glu 
                85                  90                  95      


Met Ser Thr Arg Asp Arg Phe Gln Leu Thr Gly Asp Pro Gly Lys Gly 
            100                 105                 110         


Ser Cys Ser Leu Val Ile Arg Asp Ala Gln Arg Glu Asp Glu Ala Trp 
        115                 120                 125             


Tyr Phe Phe Arg Val Glu Arg Gly Ser Arg Val Arg His Ser Phe Leu 
    130                 135                 140                 


Ser Asn Ala Phe Phe Leu Lys Val Thr Ala Leu Thr Lys Lys Pro Asp 
145                 150                 155                 160 


Val Tyr Ile Pro Glu Thr Leu Glu Pro Gly Gln Pro Val Thr Val Ile 
                165                 170                 175     


Cys Val Phe Asn Trp Ala Phe Lys Lys Cys Pro Ala Pro Ser Phe Ser 
            180                 185                 190         


Trp Thr Gly Ala Ala Leu Ser Pro Arg Arg Thr Arg Pro Ser Thr Ser 
        195                 200                 205             


His Phe Ser Val Leu Ser Phe Thr Pro Ser Pro Gln Asp His Asp Thr 
    210                 215                 220                 


Asp Leu Thr Cys His Val Asp Phe Ser Arg Lys Gly Val Ser Ala Gln 
225                 230                 235                 240 


Arg Thr Val Arg Leu Arg Val Ala Tyr Ala Pro Lys Asp Leu Ile Ile 
                245                 250                 255     


Ser Ile Ser His Asp Asn Thr Ser Ala Leu Glu Leu Gln Gly Asn Val 
            260                 265                 270         


Ile Tyr Leu Glu Val Gln Lys Gly Gln Phe Leu Arg Leu Leu Cys Ala 
        275                 280                 285             


Ala Asp Ser Gln Pro Pro Ala Thr Leu Ser Trp Val Leu Gln Asp Arg 
    290                 295                 300                 


Val Leu Ser Ser Ser His Pro Trp Gly Pro Arg Thr Leu Gly Leu Glu 
305                 310                 315                 320 


Leu Arg Gly Val Arg Ala Gly Asp Ser Gly Arg Tyr Thr Cys Arg Ala 
                325                 330                 335     


Glu Asn Arg Leu Gly Ser Gln Gln Gln Ala Leu Asp Leu Ser Val Gln 
            340                 345                 350         


Tyr Pro Pro Glu Asn Leu Arg Val Met Val Ser Gln Ala Asn Arg Thr 
        355                 360                 365             


Val Leu Glu Asn Leu Gly Asn Gly Thr Ser Leu Pro Val Leu Glu Gly 
    370                 375                 380                 


Gln Ser Leu Arg Leu Val Cys Val Thr His Ser Ser Pro Pro Ala Arg 
385                 390                 395                 400 


Leu Ser Trp Thr Arg Trp Gly Gln Thr Val Gly Pro Ser Gln Pro Ser 
                405                 410                 415     


Asp Pro Gly Val Leu Glu Leu Pro Pro Ile Gln Met Glu His Glu Gly 
            420                 425                 430         


Glu Phe Thr Cys His Ala Gln His Pro Leu Gly Ser Gln His Val Ser 
        435                 440                 445             


Leu Ser Leu Ser Val His Tyr Pro Pro Gln Leu Leu Gly Pro Ser Cys 
    450                 455                 460                 


Ser Trp Glu Ala Glu Gly Leu His Cys Ser Cys Ser Ser Gln Ala Ser 
465                 470                 475                 480 


Pro Ala Pro Ser Leu Arg Trp Trp Leu Gly Glu Glu Leu Leu Glu Gly 
                485                 490                 495     


Asn Ser Ser Gln Gly Ser Phe Glu Val Thr Pro Ser Ser Ala Gly Pro 
            500                 505                 510         


Trp Ala Asn Ser Ser Leu Ser Leu His Gly Gly Leu Ser Ser Gly Leu 
        515                 520                 525             


Arg Leu Arg Cys Lys Ala Trp Asn Val His Gly Ala Gln Ser Gly Ser 
    530                 535                 540                 


Val Phe Gln Leu Leu Pro Gly Lys Leu Glu His Gly Gly Gly Leu Gly 
545                 550                 555                 560 


Leu Gly Ala Ala Leu Gly Ala Gly Val Ala Ala Leu Leu Ala Phe Cys 
                565                 570                 575     


Ser Cys Leu Val Val Phe Arg Val Lys Ile Cys Arg Lys Glu Ala Arg 
            580                 585                 590         


Lys Arg Ala Ala Ala Glu Gln Asp Val Pro Ser Thr Leu Gly Pro Ile 
        595                 600                 605             


Ser Gln Gly His Gln His Glu Cys Ser Ala Gly Ser Ser Gln Asp His 
    610                 615                 620                 


Pro Pro Pro Gly Ala Ala Thr Tyr Thr Pro Gly Lys Gly Glu Glu Gln 
625                 630                 635                 640 


Glu Leu His Tyr Ala Ser Leu Ser Phe Gln Gly Leu Arg Leu Trp Glu 
                645                 650                 655     


Pro Ala Asp Gln Glu Ala Pro Ser Thr Thr Glu Tyr Ser Glu Ile Lys 
            660                 665                 670         


Ile His Thr Gly Gln Pro Leu Arg Gly Pro Gly Phe Gly Leu Gln Leu 
        675                 680                 685             


Glu Arg Glu Met Ser Gly Met Val Pro Lys 
    690                 695             


<210>  5526
<211>  648
<212>  PRT
<213>  Homo sapiens

<400>  5526

Met Ser Arg Lys Ala Ser Glu Asn Val Glu Tyr Thr Leu Arg Ser Leu 
1               5                   10                  15      


Ser Ser Leu Met Gly Glu Arg Arg Arg Lys Gln Pro Glu Pro Asp Ala 
            20                  25                  30          


Ala Ser Ala Ala Gly Glu Cys Ser Leu Leu Ala Ala Ala Glu Ser Ser 
        35                  40                  45              


Thr Ser Leu Gln Ser Ala Gly Ala Gly Gly Gly Gly Val Gly Asp Leu 
    50                  55                  60                  


Glu Arg Ala Ala Arg Arg Gln Phe Gln Gln Asp Glu Thr Pro Ala Phe 
65                  70                  75                  80  


Val Tyr Val Val Ala Val Phe Ser Ala Leu Gly Gly Phe Leu Phe Gly 
                85                  90                  95      


Tyr Asp Thr Gly Val Val Ser Gly Ala Met Leu Leu Leu Lys Arg Gln 
            100                 105                 110         


Leu Ser Leu Asp Ala Leu Trp Gln Glu Leu Leu Val Ser Ser Thr Val 
        115                 120                 125             


Gly Ala Ala Ala Val Ser Ala Leu Ala Gly Gly Ala Leu Asn Gly Val 
    130                 135                 140                 


Phe Gly Arg Arg Ala Ala Ile Leu Leu Ala Ser Ala Leu Phe Thr Ala 
145                 150                 155                 160 


Gly Ser Ala Val Leu Ala Ala Ala Asn Asn Lys Glu Thr Leu Leu Ala 
                165                 170                 175     


Gly Arg Leu Val Val Gly Leu Gly Ile Gly Ile Ala Ser Met Thr Val 
            180                 185                 190         


Pro Val Tyr Ile Ala Glu Val Ser Pro Pro Asn Leu Arg Gly Arg Leu 
        195                 200                 205             


Val Thr Ile Asn Thr Leu Phe Ile Thr Gly Gly Gln Phe Phe Ala Ser 
    210                 215                 220                 


Val Val Asp Gly Ala Phe Ser Tyr Leu Gln Lys Asp Gly Trp Arg Tyr 
225                 230                 235                 240 


Met Leu Gly Leu Ala Ala Val Pro Ala Val Ile Gln Phe Phe Gly Phe 
                245                 250                 255     


Leu Phe Leu Pro Glu Ser Pro Arg Trp Leu Ile Gln Lys Gly Gln Thr 
            260                 265                 270         


Gln Lys Ala Arg Arg Ile Leu Ser Gln Met Arg Gly Asn Gln Thr Ile 
        275                 280                 285             


Asp Glu Glu Tyr Asp Ser Ile Lys Asn Asn Ile Glu Glu Glu Glu Lys 
    290                 295                 300                 


Glu Val Gly Ser Ala Gly Pro Val Ile Cys Arg Met Leu Ser Tyr Pro 
305                 310                 315                 320 


Pro Thr Arg Arg Ala Leu Ile Val Gly Cys Gly Leu Gln Met Phe Gln 
                325                 330                 335     


Gln Leu Ser Gly Ile Asn Thr Ile Met Tyr Tyr Ser Ala Thr Ile Leu 
            340                 345                 350         


Gln Met Ser Gly Val Glu Asp Asp Arg Leu Ala Ile Trp Leu Ala Ser 
        355                 360                 365             


Val Thr Ala Phe Thr Asn Phe Ile Phe Thr Leu Val Gly Val Trp Leu 
    370                 375                 380                 


Val Glu Lys Val Gly Arg Arg Lys Leu Thr Phe Gly Ser Leu Ala Gly 
385                 390                 395                 400 


Thr Thr Val Ala Leu Ile Ile Leu Ala Leu Gly Phe Val Leu Ser Ala 
                405                 410                 415     


Gln Val Ser Pro Arg Ile Thr Phe Lys Pro Ile Ala Pro Ser Gly Gln 
            420                 425                 430         


Asn Ala Thr Cys Thr Arg Tyr Ser Tyr Cys Asn Glu Cys Met Leu Asp 
        435                 440                 445             


Pro Asp Cys Gly Phe Cys Tyr Lys Met Asn Lys Ser Thr Val Ile Asp 
    450                 455                 460                 


Ser Ser Cys Val Pro Val Asn Lys Ala Ser Thr Asn Glu Ala Ala Trp 
465                 470                 475                 480 


Gly Arg Cys Glu Asn Glu Thr Lys Phe Lys Thr Glu Asp Ile Phe Trp 
                485                 490                 495     


Ala Tyr Asn Phe Cys Pro Thr Pro Tyr Ser Trp Thr Ala Leu Leu Gly 
            500                 505                 510         


Leu Ile Leu Tyr Leu Val Phe Phe Ala Pro Gly Met Gly Pro Met Pro 
        515                 520                 525             


Trp Thr Val Asn Ser Glu Ile Tyr Pro Leu Trp Ala Arg Ser Thr Gly 
    530                 535                 540                 


Asn Ala Cys Ser Ser Gly Ile Asn Trp Ile Phe Asn Val Leu Val Ser 
545                 550                 555                 560 


Leu Thr Phe Leu His Thr Ala Glu Tyr Leu Thr Tyr Tyr Gly Ala Phe 
                565                 570                 575     


Phe Leu Tyr Ala Gly Phe Ala Ala Val Gly Leu Leu Phe Ile Tyr Gly 
            580                 585                 590         


Cys Leu Pro Glu Thr Lys Gly Lys Lys Leu Glu Glu Ile Glu Ser Leu 
        595                 600                 605             


Phe Asp Asn Arg Leu Cys Thr Cys Gly Thr Ser Asp Ser Asp Glu Gly 
    610                 615                 620                 


Arg Tyr Ile Glu Tyr Ile Arg Val Lys Gly Ser Asn Tyr His Leu Ser 
625                 630                 635                 640 


Asp Asn Asp Ala Ser Asp Val Glu 
                645             


<210>  5527
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  5527

Met Ser Ala Gly Gly Ala Ser Val Pro Pro Pro Pro Asn Pro Ala Val 
1               5                   10                  15      


Ser Phe Pro Pro Pro Arg Val Thr Leu Pro Ala Gly Pro Asp Ile Leu 
            20                  25                  30          


Arg Thr Tyr Ser Gly Ala Phe Val Cys Leu Glu Ile Leu Phe Gly Gly 
        35                  40                  45              


Leu Val Trp Ile Leu Val Ala Ser Ser Asn Val Pro Leu Pro Leu Leu 
    50                  55                  60                  


Gln Gly Trp Val Met Phe Val Ser Val Thr Ala Phe Phe Phe Ser Leu 
65                  70                  75                  80  


Leu Phe Leu Gly Met Phe Leu Ser Gly Met Val Ala Gln Ile Asp Ala 
                85                  90                  95      


Asn Trp Asn Phe Leu Asp Phe Ala Tyr His Phe Thr Val Phe Val Phe 
            100                 105                 110         


Tyr Phe Gly Ala Phe Leu Leu Glu Ala Ala Ala Thr Ser Leu His Asp 
        115                 120                 125             


Leu His Cys Asn Thr Thr Ile Thr Gly Gln Pro Leu Leu Ser Asp Asn 
    130                 135                 140                 


Gln Tyr Asn Ile Asn Val Ala Ala Ser Ile Phe Ala Phe Met Thr Thr 
145                 150                 155                 160 


Ala Cys Tyr Gly Cys Ser Leu Gly Leu Ala Leu Arg Arg Trp Arg Pro 
                165                 170                 175     


<210>  5528
<211>  947
<212>  PRT
<213>  Homo sapiens

<400>  5528

Met Ser Trp Leu Arg Phe Trp Gly Pro Trp Pro Leu Leu Thr Trp Gln 
1               5                   10                  15      


Leu Leu Ser Leu Leu Val Lys Glu Ala Gln Pro Leu Val Trp Val Lys 
            20                  25                  30          


Asp Pro Leu Gln Leu Thr Ser Asn Pro Leu Gly Pro Pro Glu Pro Trp 
        35                  40                  45              


Ser Ser Arg Ser Ser His Leu Pro Trp Glu Ser Pro His Ala Pro Ala 
    50                  55                  60                  


Pro Pro Ala Ala Pro Gly Asp Phe Asp Tyr Leu Gly Pro Ser Ala Ser 
65                  70                  75                  80  


Ser Gln Met Ser Ala Leu Pro Gln Glu Pro Thr Glu Asn Leu Ala Pro 
                85                  90                  95      


Phe Leu Lys Glu Leu Asp Ser Ala Gly Glu Leu Pro Leu Gly Pro Glu 
            100                 105                 110         


Pro Phe Leu Ala Ala His Gln Asp Leu Asn Asp Lys Arg Thr Pro Glu 
        115                 120                 125             


Glu Arg Leu Pro Glu Val Val Pro Leu Leu Asn Arg Asp Gln Asn Gln 
    130                 135                 140                 


Ala Leu Val Gln Leu Pro Arg Leu Lys Trp Val Gln Thr Thr Asp Leu 
145                 150                 155                 160 


Asp Arg Ala Ala Gly His Gln Ala Asp Glu Ile Leu Val Pro Leu Asp 
                165                 170                 175     


Ser Lys Val Ser Arg Pro Thr Lys Phe Val Val Ser Pro Lys Asn Leu 
            180                 185                 190         


Lys Lys Asp Leu Ala Glu Arg Trp Ser Leu Pro Glu Ile Val Gly Ile 
        195                 200                 205             


Pro His Gln Leu Ser Lys Pro Gln Arg Gln Lys Gln Thr Leu Pro Asp 
    210                 215                 220                 


Asp Tyr Leu Ser Met Asp Thr Leu Tyr Pro Gly Ser Leu Pro Pro Glu 
225                 230                 235                 240 


Leu Arg Val Asn Ala Asp Glu Pro Pro Gly Pro Pro Glu Gln Val Gly 
                245                 250                 255     


Leu Ser Gln Phe His Leu Glu Pro Lys Ser Gln Asn Pro Glu Thr Leu 
            260                 265                 270         


Glu Asp Ile Gln Ser Ser Ser Leu Gln Glu Glu Ala Pro Ala Gln Leu 
        275                 280                 285             


Leu Gln Leu Pro Gln Glu Val Glu Pro Ser Thr Gln Gln Glu Ala Pro 
    290                 295                 300                 


Ala Leu Pro Pro Glu Ser Ser Met Glu Ser Leu Ala Gln Thr Pro Leu 
305                 310                 315                 320 


Asn His Glu Val Thr Val Gln Pro Pro Gly Glu Asp Gln Ala His Tyr 
                325                 330                 335     


Asn Leu Pro Lys Phe Thr Val Lys Pro Ala Asp Val Glu Val Thr Met 
            340                 345                 350         


Thr Ser Glu Pro Lys Asn Glu Thr Glu Ser Thr Gln Ala Gln Gln Glu 
        355                 360                 365             


Ala Pro Ile Gln Pro Pro Glu Glu Ala Glu Pro Ser Ser Thr Ala Leu 
    370                 375                 380                 


Arg Thr Thr Asp Pro Pro Pro Glu His Pro Glu Val Thr Leu Pro Pro 
385                 390                 395                 400 


Ser Asp Lys Gly Gln Ala Gln His Ser His Leu Thr Glu Ala Thr Val 
                405                 410                 415     


Gln Pro Leu Asp Leu Glu Leu Ser Ile Thr Thr Glu Pro Thr Thr Glu 
            420                 425                 430         


Val Lys Pro Ser Pro Thr Thr Glu Glu Thr Ser Ala Gln Pro Pro Asp 
        435                 440                 445             


Pro Gly Leu Ala Ile Thr Pro Glu Pro Thr Thr Glu Ile Gly His Ser 
    450                 455                 460                 


Thr Ala Leu Glu Lys Thr Arg Ala Pro His Pro Asp Gln Val Gln Thr 
465                 470                 475                 480 


Leu His Arg Ser Leu Thr Glu Val Thr Gly Pro Pro Thr Lys Leu Glu 
                485                 490                 495     


Ser Ser Gln Asp Ser Leu Val Gln Ser Glu Thr Ala Pro Glu Glu Gln 
            500                 505                 510         


Lys Ala Ser Thr Ser Thr Asn Ile Cys Glu Leu Cys Thr Cys Gly Asp 
        515                 520                 525             


Glu Thr Leu Ser Cys Val Gly Leu Ser Pro Lys Gln Arg Leu Arg Gln 
    530                 535                 540                 


Val Pro Val Pro Glu Pro Asp Thr Tyr Asn Gly Ile Phe Thr Thr Leu 
545                 550                 555                 560 


Asn Phe Gln Gly Asn Tyr Ile Ser Tyr Leu Asp Gly Asn Val Trp Lys 
                565                 570                 575     


Ala Tyr Ser Trp Thr Glu Lys Leu Ile Leu Ser Glu Asn Tyr Leu Thr 
            580                 585                 590         


Glu Leu Pro Lys Asp Ser Phe Glu Gly Leu Leu Tyr Leu Gln Tyr Leu 
        595                 600                 605             


Asp Leu Ser Cys Asn Lys Ile Arg Tyr Ile Glu Arg Gln Thr Phe Glu 
    610                 615                 620                 


Ser Leu Pro Phe Leu Gln Tyr Ile Asn Leu Gly Cys Asn Leu Ile Thr 
625                 630                 635                 640 


Lys Leu Ser Leu Gly Thr Phe Gln Ala Trp His Gly Met Gln Phe Leu 
                645                 650                 655     


His Asn Leu Ile Leu Asn Arg Asn Pro Leu Thr Thr Val Glu Asp Pro 
            660                 665                 670         


Tyr Leu Phe Glu Leu Pro Ala Leu Lys Tyr Leu Asp Met Gly Thr Thr 
        675                 680                 685             


His Ile Thr Leu Thr Thr Leu Lys Asn Ile Leu Thr Met Thr Val Glu 
    690                 695                 700                 


Leu Glu Lys Leu Ile Leu Pro Ser His Met Ala Cys Cys Leu Cys Gln 
705                 710                 715                 720 


Phe Lys Asn Ser Ile Glu Ala Val Cys Lys Thr Val Lys Leu His Cys 
                725                 730                 735     


Asn Thr Ala Cys Leu Thr Asn Ser Ile His Cys Pro Glu Glu Ala Ser 
            740                 745                 750         


Val Gly Asn Pro Glu Gly Ala Phe Met Lys Met Leu Gln Ala Arg Lys 
        755                 760                 765             


Gln His Met Ser Thr Gln Leu Thr Ile Glu Ser Glu Ala Pro Ser Asp 
    770                 775                 780                 


Ser Ser Gly Ile Asn Leu Ser Gly Phe Gly Gly Asp Gln Leu Glu Ile 
785                 790                 795                 800 


Gln Leu Thr Glu Gln Leu Arg Ser Leu Ile Pro Asn Glu Asp Val Arg 
                805                 810                 815     


Lys Phe Met Ser His Val Ile Arg Thr Leu Lys Met Glu Cys Ser Glu 
            820                 825                 830         


Thr His Val Gln Gly Ser Cys Ala Lys Leu Met Leu Arg Thr Gly Leu 
        835                 840                 845             


Leu Met Lys Leu Leu Ser Glu Gln Gln Glu Ala Lys Ala Leu Asn Val 
    850                 855                 860                 


Glu Trp Asp Thr Asp Gln Gln Lys Thr Asn Tyr Ile Asn Glu Asn Met 
865                 870                 875                 880 


Glu Gln Asn Glu Gln Lys Glu Gln Lys Ser Ser Glu Leu Met Lys Glu 
                885                 890                 895     


Val Pro Gly Asp Asp Tyr Lys Asn Lys Leu Ile Phe Ala Ile Ser Val 
            900                 905                 910         


Thr Val Ile Leu Ile Ile Leu Ile Ile Ile Phe Cys Leu Ile Glu Val 
        915                 920                 925             


Asn Ser His Lys Arg Ala Ser Glu Lys Tyr Lys Asp Asn Pro Ser Ile 
    930                 935                 940                 


Ser Gly Ala 
945         


<210>  5529
<211>  2459
<212>  PRT
<213>  Homo sapiens

<400>  5529

Met Ser Ala Val Gly Leu Val Leu Leu Val Leu Ala Leu Arg Leu Arg 
1               5                   10                  15      


Ala Thr Thr Val Lys Pro Glu Glu Gly Ser Phe Cys Ser Asn Ser Gln 
            20                  25                  30          


Val Ala Phe Arg Asp Ala Cys Tyr Glu Phe Val Pro Leu Gly Arg Thr 
        35                  40                  45              


Phe Arg Asp Ala Gln Ser Trp Cys Glu Gly Gln Gly Gly His Leu Val 
    50                  55                  60                  


Phe Ile Gln Asp Glu Gly Thr Gln Trp Phe Leu Gln Lys His Ile Ser 
65                  70                  75                  80  


Gln Asp Arg Glu Trp Trp Ile Gly Leu Thr Trp Asn Leu Ala Arg Asn 
                85                  90                  95      


Gly Thr Thr Glu Gly Pro Gly Thr Trp Leu Asp Thr Ser Asn Val Thr 
            100                 105                 110         


Tyr Ser Asn Trp His Gly Gly Gln Ala Ala Ala Ala Pro Asp Thr Cys 
        115                 120                 125             


Gly His Ile Gly Arg Gly Pro Ser Ser Glu Trp Val Thr Ser Asp Cys 
    130                 135                 140                 


Ala Gln Thr Phe Ala Phe Met Cys Glu Phe Arg Val Gly Gln Ser Leu 
145                 150                 155                 160 


Ala Cys Glu Gly Leu Asn Ala Thr Val His Cys Gly Leu Gly Gln Val 
                165                 170                 175     


Ile Gln Val Gln Asp Ala Val Tyr Gly Arg Gln Asn Pro His Phe Cys 
            180                 185                 190         


Thr Gln Asp Ala Gly Arg Pro Ser Asp Leu Glu Gln Gly Cys Ser Trp 
        195                 200                 205             


Ala Asn Val Lys Glu Glu Val Ala Gly Gln Cys Gln Glu Leu Gln Ser 
    210                 215                 220                 


Cys Gln Val Ala Ala Asp Glu Thr Tyr Phe Gly Asn Leu Cys Pro Thr 
225                 230                 235                 240 


Gln Gly Ser Tyr Leu Trp Val Gln Tyr Gln Cys Arg Glu Ala Leu Gln 
                245                 250                 255     


Leu Met Val Ser Ser Glu Ser Phe Ile Phe Asp Asn Val Thr Ile Ser 
            260                 265                 270         


Leu Thr Trp Leu Leu Ser Pro Tyr Ile Gly Asn Leu Ser Cys Ile Ile 
        275                 280                 285             


Ser Thr Gly Asp Ser His Thr Phe Asp Pro Tyr Asn Pro Pro Ser Val 
    290                 295                 300                 


Ser Ser Asn Val Thr His Gln Phe Thr Ser Pro Gly Glu Phe Thr Val 
305                 310                 315                 320 


Phe Ala Glu Cys Thr Thr Ser Glu Trp His Val Thr Ala Gln Arg Gln 
                325                 330                 335     


Val Thr Val Arg Asp Lys Met Glu Thr Leu Ser Val Thr Ala Cys Ser 
            340                 345                 350         


Gly Leu Ser Gln Ser Gly Ala Gly Pro Leu Cys Gln Ala Val Phe Gly 
        355                 360                 365             


Asp Pro Leu Trp Ile Gln Val Glu Leu Asp Gly Gly Thr Gly Val Thr 
    370                 375                 380                 


Tyr Thr Val Leu Leu Gly Asp Ile Thr Leu Ala Glu Ser Thr Thr Gln 
385                 390                 395                 400 


Lys Gly Ser Leu Pro Tyr Asn Leu Ile Leu Asp Arg Glu Thr Gln Lys 
                405                 410                 415     


Leu Met Gly Pro Gly Arg His Arg Leu Glu Ile Gln Ala Thr Gly Asn 
            420                 425                 430         


Thr Thr Thr Ser Thr Ile Ser Arg Asn Ile Thr Val His Leu Val Glu 
        435                 440                 445             


Leu Leu Ser Gly Leu Gln Ala Ser Trp Ala Ser Asp His Leu Glu Leu 
    450                 455                 460                 


Gly Gln Asp Leu Leu Ile Thr Ile Ser Leu Ala Gln Gly Thr Pro Glu 
465                 470                 475                 480 


Glu Leu Thr Phe Glu Val Ala Gly Leu Asn Ala Thr Phe Ser His Glu 
                485                 490                 495     


Gln Val Ser Phe Gly Glu Pro Phe Gly Ile Cys Arg Leu Ala Val Pro 
            500                 505                 510         


Val Glu Gly Thr Phe Leu Val Thr Met Leu Val Arg Asn Ala Phe Ser 
        515                 520                 525             


Asn Leu Ser Leu Glu Ile Gly Asn Ile Thr Ile Thr Ala Pro Ser Gly 
    530                 535                 540                 


Leu Gln Glu Pro Ser Gly Met Asn Ala Glu Gly Lys Ser Lys Asp Lys 
545                 550                 555                 560 


Gly Asp Met Glu Val Tyr Ile Gln Pro Gly Pro Tyr Val Asp Pro Phe 
                565                 570                 575     


Thr Thr Val Thr Leu Gly Trp Pro Asp Asn Asp Lys Glu Leu Arg Phe 
            580                 585                 590         


Gln Trp Ser Cys Gly Ser Cys Trp Ala Leu Trp Ser Ser Cys Val Glu 
        595                 600                 605             


Arg Gln Leu Leu Arg Thr Asp Gln Arg Glu Leu Val Val Pro Ala Ser 
    610                 615                 620                 


Cys Leu Pro Pro Pro Asp Ser Ala Val Thr Leu Arg Leu Ala Val Leu 
625                 630                 635                 640 


Arg Gly Gln Glu Leu Glu Asn Arg Ala Glu Gln Cys Leu Tyr Val Ser 
                645                 650                 655     


Ala Pro Trp Glu Leu Arg Pro Arg Val Ser Cys Glu Arg Asn Cys Arg 
            660                 665                 670         


Pro Val Asn Ala Ser Lys Asp Ile Leu Leu Arg Val Thr Met Gly Glu 
        675                 680                 685             


Asp Ser Pro Val Ala Met Phe Ser Trp Tyr Leu Asp Asn Thr Pro Thr 
    690                 695                 700                 


Glu Gln Ala Glu Pro Leu Leu Asp Ala Cys Arg Leu Arg Gly Phe Trp 
705                 710                 715                 720 


Pro Arg Ser Leu Thr Leu Leu Gln Ser Asn Thr Ser Thr Leu Leu Leu 
                725                 730                 735     


Asn Ser Ser Phe Leu Gln Ser Arg Gly Glu Val Ile Arg Ile Arg Ala 
            740                 745                 750         


Thr Ala Leu Thr Arg His Ala Tyr Gly Glu Asp Thr Tyr Val Ile Ser 
        755                 760                 765             


Thr Val Pro Pro Arg Glu Val Pro Ala Cys Thr Ile Ala Pro Glu Glu 
    770                 775                 780                 


Gly Thr Val Leu Thr Ser Phe Ala Ile Phe Cys Asn Ala Ser Thr Ala 
785                 790                 795                 800 


Leu Gly Pro Leu Glu Phe Cys Phe Cys Leu Glu Ser Gly Ser Cys Leu 
                805                 810                 815     


His Cys Gly Pro Glu Pro Ala Leu Pro Ser Val Tyr Leu Pro Leu Gly 
            820                 825                 830         


Glu Glu Asn Asn Asp Phe Val Leu Thr Val Val Ile Ser Ala Thr Asn 
        835                 840                 845             


Arg Ala Gly Asp Thr Gln Gln Thr Gln Ala Met Ala Lys Val Ala Leu 
    850                 855                 860                 


Gly Asp Thr Cys Val Glu Asp Val Ala Phe Gln Ala Ala Val Ser Glu 
865                 870                 875                 880 


Lys Ile Pro Thr Ala Leu Gln Gly Glu Gly Gly Pro Glu Gln Leu Leu 
                885                 890                 895     


Gln Leu Ala Lys Ala Val Ser Ser Met Leu Asn Gln Glu His Glu Ser 
            900                 905                 910         


Gln Gly Ser Gly Gln Ser Leu Ser Ile Asp Val Arg Gln Lys Val Arg 
        915                 920                 925             


Glu His Val Leu Gly Ser Leu Ser Ala Val Thr Thr Gly Leu Glu Asp 
    930                 935                 940                 


Val Gln Arg Val Gln Glu Leu Ala Glu Val Leu Arg Glu Val Thr Cys 
945                 950                 955                 960 


Arg Ser Lys Glu Leu Thr Pro Ser Ala Gln Trp Glu Ala Ser Leu Ala 
                965                 970                 975     


Leu Gln His Ala Ser Glu Ala Leu Leu Thr Val Ser Ala Lys Ala Arg 
            980                 985                 990         


Pro Glu Asp Gln Arg Arg Gln Ala  Ala Thr Arg Asp Leu  Phe Gln Ala 
        995                 1000                 1005             


Val Gly  Ser Val Leu Glu Ala  Ser Leu Ser Asn Arg  Pro Glu Glu 
    1010                 1015                 1020             


Pro Ala  Glu Ala Ser Ser Ser  Gln Ile Ala Thr Val  Leu Arg Leu 
    1025                 1030                 1035             


Leu Arg  Val Met Glu His Val  Gln Thr Thr Leu Leu  Leu Gly Lys 
    1040                 1045                 1050             


Leu Pro  Gly Gly Leu Pro Ala  Met Leu Ala Thr Pro  Ser Ile Ser 
    1055                 1060                 1065             


Val Tyr  Thr Asn Arg Ile Gln  Pro Trp Ser Trp Gln  Gly Ser Ser 
    1070                 1075                 1080             


Leu Arg  Pro Asp Ala Ala Asp  Ser Ala Thr Phe Met  Leu Pro Ala 
    1085                 1090                 1095             


Ala Ser  Ser Leu Ser Ser Leu  Glu Gly Gly Gln Glu  Pro Val Asp 
    1100                 1105                 1110             


Ile Lys  Ile Met Ser Phe Pro  Lys Ser Pro Phe Pro  Ala Arg Ser 
    1115                 1120                 1125             


His Phe  Asp Val Ser Gly Thr  Val Gly Gly Leu Arg  Val Thr Ser 
    1130                 1135                 1140             


Pro Ser  Gly Gln Leu Ile Pro  Val Lys Asn Leu Ser  Glu Asn Ile 
    1145                 1150                 1155             


Glu Ile  Leu Leu Pro Arg His  Ser Gln Arg His Ser  Gln Pro Thr 
    1160                 1165                 1170             


Val Leu  Asn Leu Thr Ser Pro  Glu Ala Leu Trp Val  Asn Val Thr 
    1175                 1180                 1185             


Ser Gly  Glu Ala Thr Leu Gly  Ile Gln Leu His Trp  Arg Pro Asp 
    1190                 1195                 1200             


Ile Ala  Leu Thr Leu Ser Leu  Gly Tyr Gly Tyr His  Pro Asn Lys 
    1205                 1210                 1215             


Ser Ser  Tyr Asp Ala Gln Thr  His Leu Val Pro Met  Val Ala Pro 
    1220                 1225                 1230             


Asp Glu  Leu Pro Thr Trp Ile  Leu Ser Pro Gln Asp  Leu Arg Phe 
    1235                 1240                 1245             


Gly Glu  Gly Val Tyr Tyr Leu  Thr Val Val Pro Glu  Ser Asp Leu 
    1250                 1255                 1260             


Glu Pro  Ala Pro Gly Arg Asp  Leu Thr Val Gly Ile  Thr Thr Phe 
    1265                 1270                 1275             


Leu Ser  His Cys Val Phe Trp  Asp Glu Val Gln Glu  Thr Trp Asp 
    1280                 1285                 1290             


Asp Ser  Gly Cys Gln Val Gly  Pro Arg Thr Ser Pro  Tyr Gln Thr 
    1295                 1300                 1305             


His Cys  Leu Cys Asn His Leu  Thr Phe Phe Gly Ser  Thr Phe Leu 
    1310                 1315                 1320             


Val Met  Ser Asn Ala Ile Asn  Ile His Gln Thr Ala  Glu Leu Phe 
    1325                 1330                 1335             


Ala Thr  Phe Glu Asp Asn Pro  Val Val Val Thr Thr  Val Gly Cys 
    1340                 1345                 1350             


Leu Cys  Val Val Tyr Val Leu  Val Val Ile Trp Ala  Arg Arg Lys 
    1355                 1360                 1365             


Asp Ala  Gln Asp Gln Ala Lys  Val Lys Val Thr Val  Leu Glu Asp 
    1370                 1375                 1380             


Asn Asp  Pro Phe Ala Gln Tyr  His Tyr Leu Val Thr  Val Tyr Thr 
    1385                 1390                 1395             


Gly His  Arg Arg Gly Ala Ala  Thr Ser Ser Lys Val  Thr Val Thr 
    1400                 1405                 1410             


Leu Tyr  Gly Leu Asp Gly Glu  Arg Glu Pro His His  Leu Ala Asp 
    1415                 1420                 1425             


Pro Asp  Thr Pro Val Phe Glu  Arg Gly Ala Val Asp  Ala Phe Leu 
    1430                 1435                 1440             


Leu Ser  Thr Leu Phe Pro Leu  Gly Glu Leu Arg Ser  Leu Arg Leu 
    1445                 1450                 1455             


Trp His  Asp Asn Ser Gly Asp  Arg Pro Ser Trp Tyr  Val Ser Arg 
    1460                 1465                 1470             


Val Leu  Val Tyr Asp Leu Val  Met Asp Arg Lys Trp  Tyr Phe Leu 
    1475                 1480                 1485             


Cys Asn  Ser Trp Leu Ser Ile  Asn Val Gly Asp Cys  Val Leu Asp 
    1490                 1495                 1500             


Lys Val  Phe Pro Val Ala Thr  Glu Gln Asp Arg Lys  Gln Phe Ser 
    1505                 1510                 1515             


His Leu  Phe Phe Met Lys Thr  Ser Ala Gly Phe Gln  Asp Gly His 
    1520                 1525                 1530             


Ile Trp  Tyr Ser Ile Phe Ser  Arg Cys Ala Arg Ser  Ser Phe Thr 
    1535                 1540                 1545             


Arg Val  Gln Arg Val Ser Cys  Cys Phe Ser Leu Leu  Leu Cys Thr 
    1550                 1555                 1560             


Met Leu  Thr Ser Ile Met Phe  Trp Gly Val Pro Lys  Asp Pro Ala 
    1565                 1570                 1575             


Glu Gln  Lys Met Asp Leu Gly  Lys Ile Glu Phe Thr  Trp Gln Glu 
    1580                 1585                 1590             


Val Met  Ile Gly Leu Glu Ser  Ser Ile Leu Met Phe  Pro Ile Asn 
    1595                 1600                 1605             


Leu Leu  Ile Val Gln Ile Phe  Gln Asn Thr Arg Pro  Arg Val Ala 
    1610                 1615                 1620             


Lys Glu  Gln Asn Thr Gly Lys  Trp Asp Arg Gly Ser  Pro Asn Leu 
    1625                 1630                 1635             


Thr Pro  Ser Pro Gln Pro Met  Glu Asp Gly Leu Leu  Thr Pro Glu 
    1640                 1645                 1650             


Ala Val  Thr Lys Asp Val Ser  Arg Ile Val Ser Ser  Leu Phe Lys 
    1655                 1660                 1665             


Ala Leu  Lys Val Pro Ser Pro  Ala Leu Gly Trp Asp  Ser Val Asn 
    1670                 1675                 1680             


Leu Met  Asp Ile Asn Ser Leu  Leu Ala Leu Val Glu  Asp Val Ile 
    1685                 1690                 1695             


Tyr Pro  Gln Asn Thr Ser Gly  Gln Val Phe Trp Glu  Glu Ala Lys 
    1700                 1705                 1710             


Lys Arg  Glu Asp Pro Val Thr  Leu Thr Leu Gly Ser  Ser Glu Met 
    1715                 1720                 1725             


Lys Glu  Lys Ser Gln Cys Pro  Lys Pro Lys Ala Ala  Arg Ser Gly 
    1730                 1735                 1740             


Pro Trp  Lys Asp Ser Ala Tyr  Arg Gln Cys Leu Tyr  Leu Gln Leu 
    1745                 1750                 1755             


Glu His  Val Glu Gln Glu Leu  Arg Leu Val Gly Pro  Arg Gly Phe 
    1760                 1765                 1770             


Ser Gln  Pro His Ser His Ala  Gln Ala Leu Arg Gln  Leu Gln Thr 
    1775                 1780                 1785             


Leu Lys  Gly Gly Leu Gly Val  Gln Pro Gly Thr Trp  Ala Pro Ala 
    1790                 1795                 1800             


His Ala  Ser Ala Leu Gln Val  Ser Lys Pro Pro Gln  Gly Leu Pro 
    1805                 1810                 1815             


Trp Trp  Cys Ile Leu Val Gly  Trp Leu Leu Val Ala  Ala Thr Ser 
    1820                 1825                 1830             


Gly Val  Ala Ala Phe Phe Thr  Met Leu Tyr Gly Leu  His Tyr Gly 
    1835                 1840                 1845             


Arg Ala  Ser Ser Leu Arg Trp  Leu Ile Ser Met Ala  Val Ser Phe 
    1850                 1855                 1860             


Val Glu  Ser Met Phe Val Thr  Gln Pro Leu Lys Val  Leu Gly Phe 
    1865                 1870                 1875             


Ala Ala  Phe Phe Ala Leu Val  Leu Lys Arg Val Asp  Asp Glu Glu 
    1880                 1885                 1890             


Asp Thr  Val Ala Pro Leu Pro  Gly His Leu Leu Gly  Pro Asp Pro 
    1895                 1900                 1905             


Tyr Ala  Leu Phe Arg Ala Arg  Arg Asn Ser Ser Arg  Asp Val Tyr 
    1910                 1915                 1920             


Gln Pro  Pro Leu Thr Ala Ala  Ile Glu Lys Met Lys  Thr Thr His 
    1925                 1930                 1935             


Leu Lys  Glu Gln Lys Ala Phe  Ala Leu Ile Arg Glu  Ile Leu Ala 
    1940                 1945                 1950             


Tyr Leu  Gly Phe Leu Trp Met  Leu Leu Leu Val Ala  Tyr Gly Gln 
    1955                 1960                 1965             


Arg Asp  Pro Ser Ala Tyr His  Leu Asn Arg His Leu  Gln His Ser 
    1970                 1975                 1980             


Phe Thr  Arg Gly Phe Ser Gly  Val Leu Gly Phe Arg  Glu Phe Phe 
    1985                 1990                 1995             


Lys Trp  Ala Asn Thr Thr Leu  Val Ser Asn Leu Tyr  Gly His Pro 
    2000                 2005                 2010             


Pro Gly  Phe Ile Thr Asp Gly  Asn Ser Lys Leu Val  Gly Ser Ala 
    2015                 2020                 2025             


Gln Ile  Arg Gln Val Arg Val  Gln Glu Ser Ser Cys  Pro Leu Ala 
    2030                 2035                 2040             


Gln Gln  Pro Gln Ala Tyr Leu  Asn Gly Cys Arg Ala  Pro Tyr Ser 
    2045                 2050                 2055             


Leu Asp  Ala Glu Asp Met Ala  Asp Tyr Gly Glu Gly  Trp Asn Ala 
    2060                 2065                 2070             


Thr Thr  Leu Ser Glu Trp Gln  Tyr Gln Ser Gln Asp  Gln Arg Gln 
    2075                 2080                 2085             


Gly Tyr  Pro Ile Trp Gly Lys  Leu Thr Val Tyr Arg  Gly Gly Gly 
    2090                 2095                 2100             


Tyr Val  Val Pro Leu Gly Thr  Asp Arg Gln Ser Thr  Ser Arg Ile 
    2105                 2110                 2115             


Leu Arg  Tyr Leu Phe Asp Asn  Thr Trp Leu Asp Ala  Leu Thr Arg 
    2120                 2125                 2130             


Ala Val  Phe Val Glu Ser Thr  Val Tyr Asn Ala Asn  Val Asn Leu 
    2135                 2140                 2145             


Phe Cys  Ile Val Thr Leu Thr  Leu Glu Thr Ser Ala  Leu Gly Thr 
    2150                 2155                 2160             


Phe Phe  Thr His Ala Ala Leu  Gln Ser Leu Arg Leu  Tyr Pro Phe 
    2165                 2170                 2175             


Thr Asp  Gly Trp His Pro Phe  Val Val Ala Ala Glu  Leu Ile Tyr 
    2180                 2185                 2190             


Phe Leu  Phe Leu Leu Tyr Tyr  Met Val Val Gln Gly  Lys Arg Met 
    2195                 2200                 2205             


Ser Lys  Glu Thr Trp Gly Tyr  Phe Cys Ser Lys Trp  Asn Leu Leu 
    2210                 2215                 2220             


Glu Leu  Ala Ile Ile Leu Ala  Ser Trp Ser Ala Leu  Ala Val Phe 
    2225                 2230                 2235             


Val Lys  Arg Ala Val Leu Ala  Glu Arg Asp Leu Gln  Arg Cys Arg 
    2240                 2245                 2250             


Asn His  Arg Glu Glu Gly Ile  Ser Phe Ser Glu Thr  Ala Ala Ala 
    2255                 2260                 2265             


Asp Ala  Ala Leu Gly Tyr Ile  Ile Ala Phe Leu Val  Leu Leu Ser 
    2270                 2275                 2280             


Thr Val  Lys Leu Trp His Leu  Leu Arg Leu Asn Pro  Lys Met Asn 
    2285                 2290                 2295             


Met Ile  Thr Ala Ala Leu Arg  Arg Ala Trp Gly Asp  Ile Ser Gly 
    2300                 2305                 2310             


Phe Met  Ile Val Ile Leu Thr  Met Leu Leu Ala Tyr  Ser Ile Ala 
    2315                 2320                 2325             


Ser Asn  Leu Ile Phe Gly Trp  Lys Leu Arg Ser Tyr  Lys Thr Leu 
    2330                 2335                 2340             


Phe Asp  Ala Ala Glu Thr Met  Val Ser Leu Gln Leu  Gly Ile Phe 
    2345                 2350                 2355             


Asn Tyr  Glu Glu Val Leu Asp  Tyr Ser Pro Val Leu  Gly Ser Phe 
    2360                 2365                 2370             


Leu Ile  Gly Ser Cys Ile Val  Phe Met Thr Phe Val  Val Leu Asn 
    2375                 2380                 2385             


Leu Phe  Ile Ser Val Ile Leu  Val Ala Phe Ser Glu  Glu Gln Lys 
    2390                 2395                 2400             


Tyr Tyr  Gln Leu Ser Glu Glu  Gly Glu Ile Val Asp  Leu Leu Leu 
    2405                 2410                 2415             


Met Lys  Ile Leu Ser Phe Leu  Gly Ile Lys Ser Lys  Arg Glu Glu 
    2420                 2425                 2430             


Pro Gly  Ser Ser Arg Glu Gln  Pro Gly Ser Leu Ser  Gln Thr Arg 
    2435                 2440                 2445             


His Ser  Arg Pro Ala Gln Ala  Leu Pro Lys Asp 
    2450                 2455                 


<210>  5530
<211>  3487
<212>  PRT
<213>  Homo sapiens

<400>  5530

Met Arg Leu Ile Ser Ile Ala Pro Gly Pro Arg Trp Gln Val Gln Ser 
1               5                   10                  15      


His His Pro Arg Ser Ala Gly Gln Asn Cys Thr Phe Gln Leu His Gly 
            20                  25                  30          


Pro Asn Gly Thr Val Glu Ser Pro Gly Phe Pro Tyr Gly Tyr Pro Asn 
        35                  40                  45              


Tyr Ala Asn Cys Thr Trp Thr Ile Thr Ala Glu Glu Gln His Arg Ile 
    50                  55                  60                  


Gln Leu Val Phe Gln Ser Phe Ala Leu Glu Glu Asp Phe Asp Val Leu 
65                  70                  75                  80  


Ser Val Phe Asp Gly Pro Pro Gln Pro Glu Asn Leu Arg Thr Arg Leu 
                85                  90                  95      


Thr Gly Phe Gln Leu Pro Ala Thr Ile Val Ser Ala Ala Thr Thr Leu 
            100                 105                 110         


Ser Leu Arg Leu Ile Ser Asp Tyr Ala Val Ser Ala Gln Gly Phe His 
        115                 120                 125             


Ala Thr Tyr Glu Val Leu Pro Ser His Thr Cys Gly Asn Pro Gly Arg 
    130                 135                 140                 


Leu Pro Asn Gly Ile Gln Gln Gly Ser Thr Phe Asn Leu Gly Asp Lys 
145                 150                 155                 160 


Val Arg Tyr Ser Cys Asn Leu Gly Phe Phe Leu Glu Gly His Ala Val 
                165                 170                 175     


Leu Thr Cys His Ala Gly Ser Glu Asn Ser Ala Thr Trp Asp Phe Pro 
            180                 185                 190         


Leu Pro Ser Cys Arg Ala Asp Asp Ala Cys Gly Gly Thr Leu Arg Gly 
        195                 200                 205             


Gln Ser Gly Ile Ile Ser Ser Pro His Phe Pro Ser Glu Tyr His Asn 
    210                 215                 220                 


Asn Ala Asp Cys Thr Trp Thr Ile Leu Ala Glu Leu Gly Asp Thr Ile 
225                 230                 235                 240 


Ala Leu Val Phe Ile Asp Phe Gln Leu Glu Asp Gly Tyr Asp Phe Leu 
                245                 250                 255     


Glu Val Thr Gly Thr Glu Gly Ser Ser Leu Trp Phe Thr Gly Ala Ser 
            260                 265                 270         


Leu Pro Ala Pro Val Ile Ser Ser Lys Asn Trp Leu Arg Leu His Phe 
        275                 280                 285             


Thr Ser Asp Gly Asn His Arg Gln Arg Gly Phe Ser Ala Gln Tyr Gln 
    290                 295                 300                 


Val Lys Lys Gln Ile Glu Leu Lys Ser Arg Gly Val Lys Leu Met Pro 
305                 310                 315                 320 


Ser Lys Asp Asn Ser Gln Lys Thr Ser Val Leu Thr Gln Val Gly Val 
                325                 330                 335     


Ser Gln Gly His Asn Met Cys Pro Asp Pro Gly Ile Pro Glu Arg Gly 
            340                 345                 350         


Lys Arg Leu Gly Ser Asp Phe Arg Leu Gly Ser Ser Val Gln Phe Thr 
        355                 360                 365             


Cys Asn Glu Gly Tyr Asp Leu Gln Gly Ser Lys Arg Ile Thr Cys Met 
    370                 375                 380                 


Lys Val Ser Asp Met Phe Ala Ala Trp Ser Asp His Arg Pro Val Cys 
385                 390                 395                 400 


Arg Ala Arg Met Cys Asp Ala His Leu Arg Gly Pro Ser Gly Ile Ile 
                405                 410                 415     


Thr Ser Pro Asn Phe Pro Ile Gln Tyr Asp Asn Asn Ala His Cys Val 
            420                 425                 430         


Trp Ile Ile Thr Ala Leu Asn Pro Ser Lys Val Ile Lys Leu Ala Phe 
        435                 440                 445             


Glu Glu Phe Asp Leu Glu Arg Gly Tyr Asp Thr Leu Thr Val Gly Asp 
    450                 455                 460                 


Gly Gly Gln Asp Gly Asp Gln Lys Thr Val Leu Tyr Ile Leu Thr Gly 
465                 470                 475                 480 


Thr Ser Val Pro Asp Leu Ile Val Ser Thr Asn His Gln Met Trp Leu 
                485                 490                 495     


Leu Phe Gln Thr Asp Gly Ser Gly Ser Ser Leu Gly Phe Lys Ala Ser 
            500                 505                 510         


Tyr Glu Glu Ile Glu Gln Gly Ser Cys Gly Asp Pro Gly Ile Pro Ala 
        515                 520                 525             


Tyr Gly Arg Arg Glu Gly Ser Arg Phe His His Gly Asp Thr Leu Lys 
    530                 535                 540                 


Phe Glu Cys Gln Pro Ala Phe Glu Leu Val Gly Gln Lys Ala Ile Thr 
545                 550                 555                 560 


Cys Gln Lys Asn Asn Gln Trp Ser Ala Lys Lys Pro Gly Cys Val Phe 
                565                 570                 575     


Ser Cys Phe Phe Asn Phe Thr Ser Pro Ser Gly Val Val Leu Ser Pro 
            580                 585                 590         


Asn Tyr Pro Glu Asp Tyr Gly Asn His Leu His Cys Val Trp Leu Ile 
        595                 600                 605             


Leu Ala Arg Pro Glu Ser Arg Ile His Leu Ala Phe Asn Asp Ile Asp 
    610                 615                 620                 


Val Glu Pro Gln Phe Asp Phe Leu Val Ile Lys Asp Gly Ala Thr Ala 
625                 630                 635                 640 


Glu Ala Pro Val Leu Gly Thr Phe Ser Gly Asn Gln Leu Pro Ser Ser 
                645                 650                 655     


Ile Thr Ser Ser Gly His Val Ala Arg Leu Glu Phe Gln Thr Asp His 
            660                 665                 670         


Ser Thr Gly Lys Arg Gly Phe Asn Ile Thr Phe Thr Thr Phe Arg His 
        675                 680                 685             


Asn Glu Cys Pro Asp Pro Gly Val Pro Val Asn Gly Lys Arg Phe Gly 
    690                 695                 700                 


Asp Ser Leu Gln Leu Gly Ser Ser Ile Ser Phe Leu Cys Asp Glu Gly 
705                 710                 715                 720 


Phe Leu Gly Thr Gln Gly Ser Glu Thr Ile Thr Cys Val Leu Lys Glu 
                725                 730                 735     


Gly Ser Val Val Trp Asn Ser Ala Val Leu Arg Cys Glu Ala Pro Cys 
            740                 745                 750         


Gly Gly His Leu Thr Ser Pro Ser Gly Thr Ile Leu Ser Pro Gly Trp 
        755                 760                 765             


Pro Gly Phe Tyr Lys Asp Ala Leu Ser Cys Ala Trp Val Ile Glu Ala 
    770                 775                 780                 


Gln Pro Gly Tyr Pro Ile Lys Ile Thr Phe Asp Arg Phe Lys Thr Glu 
785                 790                 795                 800 


Val Asn Tyr Asp Thr Leu Glu Val Arg Asp Gly Arg Thr Tyr Ser Ala 
                805                 810                 815     


Pro Leu Ile Gly Val Tyr His Gly Thr Gln Val Pro Gln Phe Leu Ile 
            820                 825                 830         


Ser Thr Ser Asn Tyr Leu Tyr Leu Leu Phe Ser Thr Asp Lys Ser His 
        835                 840                 845             


Ser Asp Ile Gly Phe Gln Leu Arg Tyr Glu Thr Ile Thr Leu Gln Ser 
    850                 855                 860                 


Asp His Cys Leu Asp Pro Gly Ile Pro Val Asn Gly Gln Arg His Gly 
865                 870                 875                 880 


Asn Asp Phe Tyr Val Gly Ala Leu Val Thr Phe Ser Cys Asp Ser Gly 
                885                 890                 895     


Tyr Thr Leu Ser Asp Gly Glu Pro Leu Glu Cys Glu Pro Asn Phe Gln 
            900                 905                 910         


Trp Ser Arg Ala Leu Pro Ser Cys Glu Ala Leu Cys Gly Gly Phe Ile 
        915                 920                 925             


Gln Gly Ser Ser Gly Thr Ile Leu Ser Pro Gly Phe Pro Asp Phe Tyr 
    930                 935                 940                 


Pro Asn Asn Leu Asn Cys Thr Trp Ile Ile Glu Thr Ser His Gly Lys 
945                 950                 955                 960 


Gly Val Phe Phe Thr Phe His Thr Phe His Leu Glu Ser Gly His Asp 
                965                 970                 975     


Tyr Leu Leu Ile Thr Glu Asn Gly Ser Phe Thr Gln Pro Leu Arg Gln 
            980                 985                 990         


Leu Thr Gly Ser Arg Leu Pro Ala  Pro Ile Ser Ala Gly  Leu Tyr Gly 
        995                 1000                 1005             


Asn Phe  Thr Ala Gln Val Arg  Phe Ile Ser Asp Phe  Ser Met Ser 
    1010                 1015                 1020             


Tyr Glu  Gly Phe Asn Ile Thr  Phe Ser Glu Tyr Asp  Leu Glu Pro 
    1025                 1030                 1035             


Cys Glu  Glu Pro Glu Val Pro  Ala Tyr Ser Ile Arg  Lys Gly Leu 
    1040                 1045                 1050             


Gln Phe  Gly Val Gly Asp Thr  Leu Thr Phe Ser Cys  Phe Pro Gly 
    1055                 1060                 1065             


Tyr Arg  Leu Glu Gly Thr Ala  Arg Ile Thr Cys Leu  Gly Gly Arg 
    1070                 1075                 1080             


Arg Arg  Leu Trp Ser Ser Pro  Leu Pro Arg Cys Val  Ala Glu Cys 
    1085                 1090                 1095             


Gly Asn  Ser Val Thr Gly Thr  Gln Gly Thr Leu Leu  Ser Pro Asn 
    1100                 1105                 1110             


Phe Pro  Val Asn Tyr Asn Asn  Asn His Glu Cys Ile  Tyr Ser Ile 
    1115                 1120                 1125             


Gln Thr  Gln Pro Gly Lys Gly  Ile Gln Leu Lys Ala  Arg Ala Phe 
    1130                 1135                 1140             


Glu Leu  Ser Glu Gly Asp Val  Leu Lys Val Tyr Asp  Gly Asn Asn 
    1145                 1150                 1155             


Asn Ser  Ala Arg Leu Leu Gly  Val Phe Ser His Ser  Glu Met Met 
    1160                 1165                 1170             


Gly Val  Thr Leu Asn Ser Thr  Ser Ser Ser Leu Trp  Leu Asp Phe 
    1175                 1180                 1185             


Ile Thr  Asp Ala Glu Asn Thr  Ser Lys Gly Phe Glu  Leu His Phe 
    1190                 1195                 1200             


Ser Ser  Phe Glu Leu Ile Lys  Cys Glu Asp Pro Gly  Thr Pro Lys 
    1205                 1210                 1215             


Phe Gly  Tyr Lys Val His Asp  Glu Gly His Phe Ala  Gly Ser Ser 
    1220                 1225                 1230             


Val Ser  Phe Ser Cys Asp Pro  Gly Tyr Ser Leu Arg  Gly Ser Glu 
    1235                 1240                 1245             


Glu Leu  Leu Cys Leu Ser Gly  Glu Arg Arg Thr Trp  Asp Arg Pro 
    1250                 1255                 1260             


Leu Pro  Thr Cys Val Ala Glu  Cys Gly Gly Thr Val  Arg Gly Glu 
    1265                 1270                 1275             


Val Ser  Gly Gln Val Leu Ser  Pro Gly Tyr Pro Ala  Pro Tyr Glu 
    1280                 1285                 1290             


His Asn  Leu Asn Cys Ile Trp  Thr Ile Glu Ala Glu  Ala Gly Cys 
    1295                 1300                 1305             


Thr Ile  Gly Leu His Phe Leu  Val Phe Asp Thr Glu  Glu Val His 
    1310                 1315                 1320             


Asp Val  Leu Arg Ile Trp Asp  Gly Pro Val Glu Ser  Gly Val Leu 
    1325                 1330                 1335             


Leu Lys  Glu Leu Ser Gly Pro  Ala Leu Pro Lys Asp  Leu His Ser 
    1340                 1345                 1350             


Thr Phe  Asn Ser Val Val Leu  Gln Phe Ser Thr Asp  Phe Phe Thr 
    1355                 1360                 1365             


Ser Lys  Gln Gly Phe Ala Ile  Gln Phe Ser Val Ser  Thr Ala Thr 
    1370                 1375                 1380             


Ser Cys  Asn Asp Pro Gly Ile  Pro Gln Asn Gly Ser  Arg Ser Gly 
    1385                 1390                 1395             


Asp Ser  Trp Glu Ala Gly Asp  Ser Thr Val Phe Gln  Cys Asp Pro 
    1400                 1405                 1410             


Gly Tyr  Ala Leu Gln Gly Ser  Ala Glu Ile Ser Cys  Val Lys Ile 
    1415                 1420                 1425             


Glu Asn  Arg Phe Phe Trp Gln  Pro Ser Pro Pro Thr  Cys Ile Ala 
    1430                 1435                 1440             


Pro Cys  Gly Gly Asp Leu Thr  Gly Pro Ser Gly Val  Ile Leu Ser 
    1445                 1450                 1455             


Pro Asn  Tyr Pro Glu Pro Tyr  Pro Pro Gly Lys Glu  Cys Asp Trp 
    1460                 1465                 1470             


Lys Val  Thr Val Ser Pro Asp  Tyr Val Ile Ala Leu  Val Phe Asn 
    1475                 1480                 1485             


Ile Phe  Asn Leu Glu Pro Gly  Tyr Asp Phe Leu His  Ile Tyr Asp 
    1490                 1495                 1500             


Gly Arg  Asp Ser Leu Ser Pro  Leu Ile Gly Ser Phe  Tyr Gly Ser 
    1505                 1510                 1515             


Gln Leu  Pro Gly Arg Ile Glu  Ser Ser Ser Asn Ser  Leu Phe Leu 
    1520                 1525                 1530             


Ala Phe  Arg Ser Asp Ala Ser  Val Ser Asn Ala Gly  Phe Val Ile 
    1535                 1540                 1545             


Asp Tyr  Thr Glu Asn Pro Arg  Glu Ser Cys Phe Asp  Pro Gly Ser 
    1550                 1555                 1560             


Ile Lys  Asn Gly Thr Arg Val  Gly Ser Asp Leu Lys  Leu Gly Ser 
    1565                 1570                 1575             


Ser Val  Thr Tyr Tyr Cys His  Gly Gly Tyr Glu Val  Glu Gly Thr 
    1580                 1585                 1590             


Ser Thr  Leu Ser Cys Ile Leu  Gly Pro Asp Gly Lys  Pro Val Trp 
    1595                 1600                 1605             


Asn Asn  Pro Arg Pro Val Cys  Thr Ala Pro Cys Gly  Gly Gln Tyr 
    1610                 1615                 1620             


Val Gly  Ser Asp Gly Val Val  Leu Ser Pro Asn Tyr  Pro Gln Asn 
    1625                 1630                 1635             


Tyr Thr  Ser Gly Gln Ile Cys  Leu Tyr Phe Val Thr  Val Pro Lys 
    1640                 1645                 1650             


Asp Tyr  Val Val Phe Gly Gln  Phe Ala Phe Phe His  Thr Ala Leu 
    1655                 1660                 1665             


Asn Asp  Val Val Glu Val His  Asp Gly His Ser Gln  His Ser Arg 
    1670                 1675                 1680             


Leu Leu  Ser Ser Leu Ser Gly  Ser His Thr Gly Glu  Ser Leu Pro 
    1685                 1690                 1695             


Leu Ala  Thr Ser Asn Gln Val  Leu Ile Lys Phe Ser  Ala Lys Gly 
    1700                 1705                 1710             


Leu Ala  Pro Ala Arg Gly Phe  His Phe Val Tyr Gln  Ala Val Pro 
    1715                 1720                 1725             


Arg Thr  Ser Ala Thr Gln Cys  Ser Ser Val Pro Glu  Pro Arg Tyr 
    1730                 1735                 1740             


Gly Lys  Arg Leu Gly Ser Asp  Phe Ser Val Gly Ala  Ile Val Arg 
    1745                 1750                 1755             


Phe Glu  Cys Asn Ser Gly Tyr  Ala Leu Gln Gly Ser  Pro Glu Ile 
    1760                 1765                 1770             


Glu Cys  Leu Pro Val Pro Gly  Ala Leu Ala Gln Trp  Asn Val Ser 
    1775                 1780                 1785             


Ala Pro  Thr Cys Val Val Pro  Cys Gly Gly Asn Leu  Thr Glu Arg 
    1790                 1795                 1800             


Arg Gly  Thr Ile Leu Ser Pro  Gly Phe Pro Glu Pro  Tyr Leu Asn 
    1805                 1810                 1815             


Ser Leu  Asn Cys Val Trp Lys  Ile Val Val Pro Glu  Gly Ala Gly 
    1820                 1825                 1830             


Ile Gln  Ile Gln Val Val Ser  Phe Val Thr Glu Gln  Asn Trp Asp 
    1835                 1840                 1845             


Ser Leu  Glu Val Phe Asp Gly  Ala Asp Asn Thr Val  Thr Met Leu 
    1850                 1855                 1860             


Gly Ser  Phe Ser Gly Thr Thr  Val Pro Ala Leu Leu  Asn Ser Thr 
    1865                 1870                 1875             


Ser Asn  Gln Leu Tyr Leu His  Phe Tyr Ser Asp Ile  Ser Val Ser 
    1880                 1885                 1890             


Ala Ala  Gly Phe His Leu Glu  Tyr Lys Thr Val Gly  Leu Ser Ser 
    1895                 1900                 1905             


Cys Pro  Glu Pro Ala Val Pro  Ser Asn Gly Val Lys  Thr Gly Glu 
    1910                 1915                 1920             


Arg Tyr  Leu Val Asn Asp Val  Val Ser Phe Gln Cys  Glu Pro Gly 
    1925                 1930                 1935             


Tyr Ala  Leu Gln Gly His Ala  His Ile Ser Cys Met  Pro Gly Thr 
    1940                 1945                 1950             


Val Arg  Arg Trp Asn Tyr Pro  Pro Pro Leu Cys Ile  Ala Gln Cys 
    1955                 1960                 1965             


Gly Gly  Thr Val Glu Glu Met  Glu Gly Val Ile Leu  Ser Pro Gly 
    1970                 1975                 1980             


Phe Pro  Gly Asn Tyr Pro Ser  Asn Met Asp Cys Ser  Trp Lys Ile 
    1985                 1990                 1995             


Ala Leu  Pro Val Gly Phe Gly  Ala His Ile Gln Phe  Leu Asn Phe 
    2000                 2005                 2010             


Ser Thr  Glu Pro Asn His Asp  Tyr Ile Glu Ile Arg  Asn Gly Pro 
    2015                 2020                 2025             


Tyr Glu  Thr Ser Arg Met Met  Gly Arg Phe Ser Gly  Ser Glu Leu 
    2030                 2035                 2040             


Pro Ser  Ser Leu Leu Ser Thr  Ser His Glu Thr Thr  Val Tyr Phe 
    2045                 2050                 2055             


His Ser  Asp His Ser Gln Asn  Arg Pro Gly Phe Lys  Leu Glu Tyr 
    2060                 2065                 2070             


Gln Asp  Leu Thr Tyr Ser His  Gln Ile Ser Ser Phe  Leu Arg Gly 
    2075                 2080                 2085             


Phe Asp  Leu Ser Glu Leu Glu  Arg Thr Asn Ser Thr  Pro Pro Val 
    2090                 2095                 2100             


Ala Ala  Ser Tyr Val Trp Asp  Leu Asp Pro Gly Cys  Glu Ala Tyr 
    2105                 2110                 2115             


Glu Leu  Gln Glu Cys Pro Asp  Pro Glu Pro Phe Ala  Asn Gly Ile 
    2120                 2125                 2130             


Val Arg  Gly Ala Gly Tyr Asn  Val Gly Gln Ser Val  Thr Phe Glu 
    2135                 2140                 2145             


Cys Leu  Pro Gly Tyr Gln Leu  Thr Gly His Pro Val  Leu Thr Cys 
    2150                 2155                 2160             


Gln His  Gly Thr Asn Arg Asn  Trp Asp His Pro Leu  Pro Lys Cys 
    2165                 2170                 2175             


Glu Val  Pro Cys Gly Gly Asn  Ile Thr Ser Ser Asn  Gly Thr Val 
    2180                 2185                 2190             


Tyr Ser  Pro Gly Phe Pro Ser  Pro Tyr Ser Ser Ser  Gln Asp Cys 
    2195                 2200                 2205             


Val Trp  Leu Ile Thr Val Pro  Ile Gly His Gly Val  Arg Leu Asn 
    2210                 2215                 2220             


Leu Ser  Leu Leu Gln Thr Glu  Pro Ser Gly Asp Phe  Ile Thr Ile 
    2225                 2230                 2235             


Trp Asp  Gly Pro Gln Gln Thr  Ala Pro Arg Leu Gly  Val Phe Thr 
    2240                 2245                 2250             


Arg Ser  Met Ala Lys Lys Thr  Val Gln Ser Ser Ser  Asn Gln Val 
    2255                 2260                 2265             


Leu Leu  Lys Phe His Arg Asp  Ala Ala Thr Gly Gly  Ile Phe Ala 
    2270                 2275                 2280             


Ile Ala  Phe Ser Ala Tyr Pro  Leu Thr Lys Cys Pro  Pro Pro Thr 
    2285                 2290                 2295             


Ile Leu  Pro Asn Ala Glu Val  Val Thr Glu Asn Glu  Glu Phe Asn 
    2300                 2305                 2310             


Ile Gly  Asp Ile Val Arg Tyr  Arg Cys Leu Pro Gly  Phe Thr Leu 
    2315                 2320                 2325             


Val Gly  Asn Glu Ile Leu Thr  Cys Lys Leu Gly Thr  Tyr Leu Gln 
    2330                 2335                 2340             


Phe Glu  Gly Pro Pro Pro Ile  Cys Glu Val His Cys  Pro Thr Asn 
    2345                 2350                 2355             


Glu Leu  Leu Thr Asp Ser Thr  Gly Val Ile Leu Ser  Gln Ser Tyr 
    2360                 2365                 2370             


Pro Gly  Ser Tyr Pro Gln Phe  Gln Thr Cys Ser Trp  Leu Val Arg 
    2375                 2380                 2385             


Val Glu  Pro Asp Tyr Asn Ile  Ser Leu Thr Val Glu  Tyr Phe Leu 
    2390                 2395                 2400             


Ser Glu  Lys Gln Tyr Asp Glu  Phe Glu Ile Phe Asp  Gly Pro Ser 
    2405                 2410                 2415             


Gly Gln  Ser Pro Leu Leu Lys  Ala Leu Ser Gly Asn  Tyr Ser Ala 
    2420                 2425                 2430             


Pro Leu  Ile Val Thr Ser Ser  Ser Asn Ser Val Tyr  Leu Arg Trp 
    2435                 2440                 2445             


Ser Ser  Asp His Ala Tyr Asn  Arg Lys Gly Phe Lys  Ile Arg Tyr 
    2450                 2455                 2460             


Ser Ala  Pro Tyr Cys Ser Leu  Pro Arg Ala Pro Leu  His Gly Phe 
    2465                 2470                 2475             


Ile Leu  Gly Gln Thr Ser Thr  Gln Pro Gly Gly Ser  Ile His Phe 
    2480                 2485                 2490             


Gly Cys  Asn Ala Gly Tyr Arg  Leu Val Gly His Ser  Met Ala Ile 
    2495                 2500                 2505             


Cys Thr  Arg His Pro Gln Gly  Tyr His Leu Trp Ser  Glu Ala Ile 
    2510                 2515                 2520             


Pro Leu  Cys Gln Ala Leu Ser  Cys Gly Leu Pro Glu  Ala Pro Lys 
    2525                 2530                 2535             


Asn Gly  Met Val Phe Gly Lys  Glu Tyr Thr Val Gly  Thr Lys Ala 
    2540                 2545                 2550             


Met Tyr  Ser Cys Ser Glu Gly  Tyr His Leu Gln Ala  Gly Ala Glu 
    2555                 2560                 2565             


Ala Thr  Ala Glu Cys Leu Asp  Thr Gly Leu Trp Ser  Asn Arg Asn 
    2570                 2575                 2580             


Val Pro  Pro Gln Cys Val Pro  Val Thr Cys Pro Asp  Val Ser Ser 
    2585                 2590                 2595             


Ile Ser  Val Glu His Gly Arg  Trp Arg Leu Ile Phe  Glu Thr Gln 
    2600                 2605                 2610             


Tyr Gln  Phe Gln Ala Gln Leu  Met Leu Ile Cys Asp  Pro Gly Tyr 
    2615                 2620                 2625             


Tyr Tyr  Thr Gly Gln Arg Val  Ile Arg Cys Gln Ala  Asn Gly Lys 
    2630                 2635                 2640             


Trp Ser  Leu Gly Asp Ser Thr  Pro Thr Cys Arg Ile  Ile Ser Cys 
    2645                 2650                 2655             


Gly Glu  Leu Pro Ile Pro Pro  Asn Gly His Arg Ile  Gly Thr Leu 
    2660                 2665                 2670             


Ser Val  Tyr Gly Ala Thr Ala  Ile Phe Ser Cys Asn  Ser Gly Tyr 
    2675                 2680                 2685             


Thr Leu  Val Gly Ser Arg Val  Arg Glu Cys Met Ala  Asn Gly Leu 
    2690                 2695                 2700             


Trp Ser  Gly Ser Glu Val Arg  Cys Leu Ala Gly His  Cys Gly Thr 
    2705                 2710                 2715             


Pro Glu  Pro Ile Val Asn Gly  His Ile Asn Gly Glu  Asn Tyr Ser 
    2720                 2725                 2730             


Tyr Arg  Gly Ser Val Val Tyr  Gln Cys Asn Ala Gly  Phe Arg Leu 
    2735                 2740                 2745             


Ile Gly  Met Ser Val Arg Ile  Cys Gln Gln Asp His  His Trp Ser 
    2750                 2755                 2760             


Gly Lys  Thr Pro Phe Cys Val  Leu Val Ser Cys Gly  His Pro Gly 
    2765                 2770                 2775             


Ser Pro  Pro His Ser Gln Met  Ser Gly Asp Ser Tyr  Thr Val Gly 
    2780                 2785                 2790             


Ala Val  Val Arg Tyr Ser Cys  Ile Gly Lys Arg Thr  Leu Val Gly 
    2795                 2800                 2805             


Asn Ser  Thr Arg Met Cys Gly  Leu Asp Gly His Trp  Thr Gly Ser 
    2810                 2815                 2820             


Leu Pro  His Cys Ser Gly Thr  Ser Val Gly Val Cys  Gly Asp Pro 
    2825                 2830                 2835             


Gly Ile  Pro Ala His Gly Ile  Arg Leu Gly Asp Ser  Phe Asp Pro 
    2840                 2845                 2850             


Gly Thr  Val Met Arg Phe Ser  Cys Glu Ala Gly His  Val Leu Arg 
    2855                 2860                 2865             


Gly Ser  Ser Glu Arg Thr Cys  Gln Ala Asn Gly Ser  Trp Ser Gly 
    2870                 2875                 2880             


Ser Gln  Pro Glu Cys Gly Val  Ile Ser Cys Gly Asn  Pro Gly Thr 
    2885                 2890                 2895             


Pro Ser  Asn Ala Arg Val Val  Phe Ser Asp Gly Leu  Val Phe Ser 
    2900                 2905                 2910             


Ser Ser  Ile Val Tyr Glu Cys  Arg Glu Gly Tyr Tyr  Ala Thr Gly 
    2915                 2920                 2925             


Leu Leu  Ser Arg His Cys Ser  Val Asn Gly Thr Trp  Thr Gly Ser 
    2930                 2935                 2940             


Asp Pro  Glu Cys Leu Val Ile  Asn Cys Gly Asp Pro  Gly Ile Pro 
    2945                 2950                 2955             


Ala Asn  Gly Leu Arg Leu Gly  Asn Asp Phe Arg Tyr  Asn Lys Thr 
    2960                 2965                 2970             


Val Thr  Tyr Gln Cys Val Pro  Gly Tyr Met Met Glu  Ser His Arg 
    2975                 2980                 2985             


Val Ser  Val Leu Ser Cys Thr  Lys Asp Arg Thr Trp  Asn Gly Thr 
    2990                 2995                 3000             


Lys Pro  Val Cys Lys Ala Leu  Met Cys Lys Pro Pro  Pro Leu Ile 
    3005                 3010                 3015             


Pro Asn  Gly Lys Val Val Gly  Ser Asp Phe Met Trp  Gly Ser Ser 
    3020                 3025                 3030             


Val Thr  Tyr Ala Cys Leu Glu  Gly Tyr Gln Leu Ser  Leu Pro Ala 
    3035                 3040                 3045             


Val Phe  Thr Cys Glu Gly Asn  Gly Ser Trp Thr Gly  Glu Leu Pro 
    3050                 3055                 3060             


Gln Cys  Phe Pro Val Phe Cys  Gly Asp Pro Gly Val  Pro Ser Arg 
    3065                 3070                 3075             


Gly Arg  Arg Glu Asp Arg Gly  Phe Ser Tyr Arg Ser  Ser Val Ser 
    3080                 3085                 3090             


Phe Ser  Cys His Pro Pro Leu  Val Leu Val Gly Ser  Pro Arg Arg 
    3095                 3100                 3105             


Phe Cys  Gln Ser Asp Gly Thr  Trp Ser Gly Thr Gln  Pro Ser Cys 
    3110                 3115                 3120             


Ile Asp  Pro Thr Leu Thr Thr  Cys Ala Asp Pro Gly  Val Pro Gln 
    3125                 3130                 3135             


Phe Gly  Ile Gln Asn Asn Ser  Gln Gly Tyr Gln Val  Gly Ser Thr 
    3140                 3145                 3150             


Val Leu  Phe Arg Cys Gln Lys  Gly Tyr Leu Leu Gln  Gly Ser Thr 
    3155                 3160                 3165             


Thr Arg  Thr Cys Leu Pro Asn  Leu Thr Trp Ser Gly  Thr Pro Pro 
    3170                 3175                 3180             


Asp Cys  Val Pro His His Cys  Arg Gln Pro Glu Thr  Pro Thr His 
    3185                 3190                 3195             


Ala Asn  Val Gly Ala Leu Asp  Leu Pro Ser Met Gly  Tyr Thr Leu 
    3200                 3205                 3210             


Ile Tyr  Ser Cys Gln Glu Gly  Phe Ser Leu Lys Gly  Gly Ser Glu 
    3215                 3220                 3225             


His Arg  Thr Cys Lys Ala Asp  Gly Ser Trp Thr Gly  Lys Pro Pro 
    3230                 3235                 3240             


Ile Cys  Leu Glu Val Arg Pro  Ser Gly Arg Pro Ile  Asn Thr Ala 
    3245                 3250                 3255             


Arg Glu  Pro Pro Leu Thr Gln  Ala Leu Ile Pro Gly  Asp Val Phe 
    3260                 3265                 3270             


Ala Lys  Asn Ser Leu Trp Lys  Gly Ala Tyr Glu Tyr  Gln Gly Lys 
    3275                 3280                 3285             


Lys Gln  Pro Ala Met Leu Arg  Val Thr Gly Phe Gln  Val Ala Asn 
    3290                 3295                 3300             


Ser Lys  Val Asn Ala Thr Met  Ile Asp His Ser Gly  Val Glu Leu 
    3305                 3310                 3315             


His Leu  Ala Gly Thr Tyr Lys  Lys Glu Asp Phe His  Leu Leu Leu 
    3320                 3325                 3330             


Gln Val  Tyr Gln Ile Thr Gly  Pro Val Glu Ile Phe  Met Asn Lys 
    3335                 3340                 3345             


Phe Lys  Asp Asp His Trp Ala  Leu Asp Gly His Val  Ser Ser Glu 
    3350                 3355                 3360             


Ser Ser  Gly Ala Thr Phe Ile  Tyr Gln Gly Ser Val  Lys Gly Gln 
    3365                 3370                 3375             


Gly Phe  Gly Gln Phe Gly Phe  Gln Arg Leu Asp Leu  Arg Leu Leu 
    3380                 3385                 3390             


Glu Ser  Asp Pro Glu Ser Ile  Gly Arg His Phe Ala  Ser Asn Ser 
    3395                 3400                 3405             


Ser Ser  Val Ala Ala Ala Ile  Leu Val Pro Phe Ile  Ala Leu Ile 
    3410                 3415                 3420             


Ile Ala  Gly Phe Val Leu Tyr  Leu Tyr Lys His Arg  Arg Arg Pro 
    3425                 3430                 3435             


Lys Val  Pro Phe Asn Gly Tyr  Ala Gly His Glu Asn  Thr Asn Val 
    3440                 3445                 3450             


Arg Ala  Thr Phe Glu Asn Pro  Met Tyr Asp Arg Asn  Ile Gln Pro 
    3455                 3460                 3465             


Thr Asp  Ile Met Ala Ser Glu  Ala Glu Phe Thr Val  Ser Thr Val 
    3470                 3475                 3480             


Cys Thr  Ala Val 
    3485         


<210>  5531
<211>  650
<212>  PRT
<213>  Homo sapiens

<400>  5531

Met Ala Ala Lys Ser Asp Gly Arg Leu Lys Met Lys Lys Ser Ser Asp 
1               5                   10                  15      


Val Ala Phe Thr Pro Leu Gln Asn Ser Asp His Ser Gly Ser Val Gln 
            20                  25                  30          


Gly Leu Ala Pro Gly Leu Pro Ser Gly Ser Gly Ala Glu Asp Glu Glu 
        35                  40                  45              


Ala Ala Gly Gly Gly Cys Cys Pro Asp Gly Gly Gly Cys Ser Arg Cys 
    50                  55                  60                  


Cys Cys Cys Cys Ala Gly Ser Gly Gly Ser Ala Gly Ser Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Val Ala Gly Pro Gly Gly Gly Gly Ala Gly Ser Ala Ala Leu 
                85                  90                  95      


Cys Leu Arg Leu Gly Arg Glu Gln Arg Arg Tyr Ser Leu Trp Asp Cys 
            100                 105                 110         


Leu Trp Ile Leu Ala Ala Val Ala Val Tyr Phe Ala Asp Val Gly Thr 
        115                 120                 125             


Asp Val Trp Leu Ala Val Asp Tyr Tyr Leu Arg Gly Gln Arg Trp Trp 
    130                 135                 140                 


Phe Gly Leu Thr Leu Phe Phe Val Val Leu Gly Ser Leu Ser Val Gln 
145                 150                 155                 160 


Val Phe Ser Phe Arg Trp Phe Val His Asp Phe Ser Thr Glu Asp Ser 
                165                 170                 175     


Ala Thr Ala Ala Ala Ala Ser Ser Cys Pro Gln Pro Gly Ala Asp Cys 
            180                 185                 190         


Lys Thr Val Val Gly Gly Gly Ser Ala Ala Gly Glu Gly Glu Ala Arg 
        195                 200                 205             


Pro Ser Thr Pro Gln Arg Gln Ala Ser Asn Ala Ser Lys Ser Asn Ile 
    210                 215                 220                 


Ala Ala Ala Asn Ser Gly Ser Asn Ser Ser Gly Ala Thr Arg Ala Ser 
225                 230                 235                 240 


Gly Lys His Arg Ser Ala Ser Cys Ser Phe Cys Ile Trp Leu Leu Gln 
                245                 250                 255     


Ser Leu Ile His Ile Leu Gln Leu Gly Gln Ile Trp Arg Tyr Phe His 
            260                 265                 270         


Thr Ile Tyr Leu Gly Ile Arg Ser Arg Gln Ser Gly Glu Asn Asp Arg 
        275                 280                 285             


Trp Arg Phe Tyr Trp Lys Met Val Tyr Glu Tyr Ala Asp Val Ser Met 
    290                 295                 300                 


Leu His Leu Leu Ala Thr Phe Leu Glu Ser Ala Pro Gln Leu Val Leu 
305                 310                 315                 320 


Gln Leu Cys Ile Ile Val Gln Thr His Ser Leu Gln Ala Leu Gln Gly 
                325                 330                 335     


Phe Thr Ala Ala Ala Ser Leu Val Ser Leu Ala Trp Ala Leu Ala Ser 
            340                 345                 350         


Tyr Gln Lys Ala Leu Arg Asp Ser Arg Asp Asp Lys Lys Pro Ile Ser 
        355                 360                 365             


Tyr Met Ala Val Ile Ile Gln Phe Cys Trp His Phe Phe Thr Ile Ala 
    370                 375                 380                 


Ala Arg Val Ile Thr Phe Ala Leu Phe Ala Ser Val Phe Gln Leu Tyr 
385                 390                 395                 400 


Phe Gly Ile Phe Ile Val Leu His Trp Cys Ile Met Thr Phe Trp Ile 
                405                 410                 415     


Val His Cys Glu Thr Glu Phe Cys Ile Thr Lys Trp Glu Glu Ile Val 
            420                 425                 430         


Phe Asp Met Val Val Gly Ile Ile Tyr Ile Phe Ser Trp Phe Asn Val 
        435                 440                 445             


Lys Glu Gly Arg Thr Arg Cys Arg Leu Phe Ile Tyr Tyr Phe Val Ile 
    450                 455                 460                 


Leu Leu Glu Asn Thr Ala Leu Ser Ala Leu Trp Tyr Leu Tyr Lys Ala 
465                 470                 475                 480 


Pro Gln Ile Ala Asp Ala Phe Ala Ile Pro Ala Leu Cys Val Val Phe 
                485                 490                 495     


Ser Ser Phe Leu Thr Gly Val Val Phe Met Leu Met Tyr Tyr Ala Phe 
            500                 505                 510         


Phe His Pro Asn Gly Pro Arg Phe Gly Gln Ser Pro Ser Cys Ala Cys 
        515                 520                 525             


Glu Asp Pro Ala Ala Ala Phe Thr Leu Pro Pro Asp Val Ala Thr Ser 
    530                 535                 540                 


Thr Leu Arg Ser Ile Ser Asn Asn Arg Ser Val Val Ser Asp Arg Asp 
545                 550                 555                 560 


Gln Lys Phe Ala Glu Arg Asp Gly Cys Val Pro Val Phe Gln Val Arg 
                565                 570                 575     


Pro Thr Ala Pro Ser Thr Pro Ser Ser Arg Pro Pro Arg Ile Glu Glu 
            580                 585                 590         


Ser Val Ile Lys Ile Asp Leu Phe Arg Asn Arg Tyr Pro Ala Trp Glu 
        595                 600                 605             


Arg His Val Leu Asp Arg Ser Leu Arg Lys Ala Ile Leu Ala Phe Glu 
    610                 615                 620                 


Cys Ser Pro Ser Pro Pro Arg Leu Gln Tyr Lys Asp Asp Ala Leu Ile 
625                 630                 635                 640 


Gln Glu Arg Leu Glu Tyr Glu Thr Thr Leu 
                645                 650 


<210>  5532
<211>  3538
<212>  PRT
<213>  Homo sapiens

<400>  5532

Met Lys Gly Ile Arg Lys Gly Glu Ser Arg Ala Lys Glu Ser Lys Pro 
1               5                   10                  15      


Trp Glu Pro Gly Lys Arg Arg Cys Ala Lys Cys Gly Arg Leu Asp Phe 
            20                  25                  30          


Ile Leu Met Lys Lys Met Gly Ile Lys Ser Gly Phe Thr Phe Trp Asn 
        35                  40                  45              


Leu Val Phe Leu Leu Thr Val Ser Cys Val Lys Gly Phe Ile Tyr Thr 
    50                  55                  60                  


Cys Gly Gly Thr Leu Lys Gly Leu Asn Gly Thr Ile Glu Ser Pro Gly 
65                  70                  75                  80  


Phe Pro Tyr Gly Tyr Pro Asn Gly Ala Asn Cys Thr Trp Val Ile Ile 
                85                  90                  95      


Ala Glu Glu Arg Asn Arg Ile Gln Ile Val Phe Gln Ser Phe Ala Leu 
            100                 105                 110         


Glu Glu Glu Tyr Asp Tyr Leu Ser Leu Tyr Asp Gly His Pro His Pro 
        115                 120                 125             


Thr Asn Phe Arg Thr Arg Leu Thr Gly Phe His Leu Pro Pro Pro Val 
    130                 135                 140                 


Thr Ser Thr Lys Ser Val Phe Ser Leu Arg Leu Thr Ser Asp Phe Ala 
145                 150                 155                 160 


Val Ser Ala His Gly Phe Lys Val Tyr Tyr Glu Glu Leu Gln Ser Ser 
                165                 170                 175     


Ser Cys Gly Asn Pro Gly Val Pro Pro Lys Gly Val Leu Tyr Gly Thr 
            180                 185                 190         


Arg Phe Asp Val Gly Asp Lys Ile Arg Tyr Ser Cys Val Thr Gly Tyr 
        195                 200                 205             


Ile Leu Asp Gly His Pro Gln Leu Thr Cys Ile Ala Asn Ser Val Asn 
    210                 215                 220                 


Thr Ala Ser Trp Asp Phe Pro Val Pro Ile Cys Arg Ala Glu Asp Ala 
225                 230                 235                 240 


Cys Gly Gly Thr Met Arg Gly Ser Ser Gly Ile Ile Ser Ser Pro Ser 
                245                 250                 255     


Phe Pro Asn Glu Tyr His Asn Asn Ala Asp Cys Thr Trp Thr Ile Val 
            260                 265                 270         


Ala Glu Pro Gly Asp Thr Ile Ser Leu Ile Phe Thr Asp Phe Gln Met 
        275                 280                 285             


Glu Glu Lys Tyr Asp Tyr Leu Glu Ile Glu Gly Ser Glu Pro Pro Thr 
    290                 295                 300                 


Ile Trp Leu Ser Gly Met Asn Ile Pro Pro Pro Ile Ile Ser Asn Lys 
305                 310                 315                 320 


Asn Trp Leu Arg Leu His Phe Val Thr Asp Ser Asn His Arg Tyr Arg 
                325                 330                 335     


Gly Phe Ser Ala Pro Tyr Gln Val Lys Lys Ala Ile Asp Phe Lys Ser 
            340                 345                 350         


Arg Gly Phe Lys Leu Phe Pro Gly Lys Asp Asn Ser Asn Lys Phe Ser 
        355                 360                 365             


Ile Leu Asn Glu Gly Gly Ile Lys Thr Ala Ser Asn Leu Cys Pro Asp 
    370                 375                 380                 


Pro Gly Glu Pro Glu Asn Gly Lys Arg Ile Gly Ser Asp Phe Ser Leu 
385                 390                 395                 400 


Gly Ser Thr Val Gln Phe Ser Cys Asp Glu Asp Tyr Val Leu Gln Gly 
                405                 410                 415     


Ala Lys Ser Ile Thr Cys Gln Arg Ile Ala Glu Val Phe Ala Ala Trp 
            420                 425                 430         


Ser Asp His Arg Pro Val Cys Lys Val Lys Thr Cys Gly Ser Asn Leu 
        435                 440                 445             


Gln Gly Pro Ser Gly Thr Phe Thr Ser Pro Asn Phe Pro Phe Gln Tyr 
    450                 455                 460                 


Asp Ser Asn Ala Gln Cys Val Trp Val Ile Thr Ala Val Asn Thr Asn 
465                 470                 475                 480 


Lys Val Ile Gln Ile Asn Phe Glu Glu Phe Asp Leu Glu Ile Gly Tyr 
                485                 490                 495     


Asp Thr Leu Thr Ile Gly Asp Gly Gly Glu Val Gly Asp Pro Arg Thr 
            500                 505                 510         


Val Leu Gln Val Leu Thr Gly Ser Phe Val Pro Asp Leu Ile Val Ser 
        515                 520                 525             


Met Ser Ser Gln Met Trp Leu His Leu Gln Thr Asp Glu Ser Val Gly 
    530                 535                 540                 


Ser Val Gly Phe Lys Val Asn Tyr Lys Glu Ile Glu Lys Glu Ser Cys 
545                 550                 555                 560 


Gly Asp Pro Gly Thr Pro Leu Tyr Gly Ile Arg Glu Gly Asp Gly Phe 
                565                 570                 575     


Ser Asn Arg Asp Val Leu Arg Phe Glu Cys Gln Phe Gly Phe Glu Leu 
            580                 585                 590         


Ile Gly Glu Lys Ser Ile Val Cys Gln Glu Asn Asn Gln Trp Ser Ala 
        595                 600                 605             


Asn Ile Pro Ile Cys Ile Phe Pro Cys Leu Ser Asn Phe Thr Ala Pro 
    610                 615                 620                 


Met Gly Thr Val Leu Ser Pro Asp Tyr Pro Glu Gly Tyr Gly Asn Asn 
625                 630                 635                 640 


Leu Asn Cys Ile Trp Thr Ile Ile Ser Asp Pro Gly Ser Arg Ile His 
                645                 650                 655     


Leu Ser Phe Asn Asp Phe Asp Leu Glu Ser Gln Phe Asp Phe Leu Ala 
            660                 665                 670         


Val Lys Asp Gly Asp Ser Pro Glu Ser Pro Ile Leu Gly Thr Phe Thr 
        675                 680                 685             


Gly Ala Glu Val Pro Ser His Leu Thr Ser Asn Ser His Ile Leu Arg 
    690                 695                 700                 


Leu Glu Phe Gln Ala Asp His Ser Met Ser Gly Arg Gly Phe Asn Ile 
705                 710                 715                 720 


Thr Tyr Asn Thr Phe Gly His Asn Glu Cys Pro Asp Pro Gly Ile Pro 
                725                 730                 735     


Ile Asn Ala Arg Arg Phe Gly Asp Asn Phe Gln Leu Gly Ser Ser Ile 
            740                 745                 750         


Ser Val Ile Cys Glu Glu Gly Phe Ile Lys Thr Gln Gly Thr Glu Thr 
        755                 760                 765             


Ile Thr Cys Ile Leu Met Asp Gly Lys Val Met Trp Ser Gly Leu Ile 
    770                 775                 780                 


Pro Lys Cys Gly Ala Pro Cys Gly Gly His Phe Ser Ala Pro Ser Gly 
785                 790                 795                 800 


Val Ile Leu Ser Pro Gly Trp Pro Gly Tyr Tyr Lys Asp Ser Leu Asn 
                805                 810                 815     


Cys Glu Trp Val Ile Glu Ala Glu Pro Gly His Ser Ile Lys Ile Thr 
            820                 825                 830         


Phe Glu Arg Phe Gln Thr Glu Leu Asn Tyr Asp Val Leu Glu Val His 
        835                 840                 845             


Asp Gly Pro Asn Leu Leu Ser Pro Leu Leu Gly Ser Tyr Asn Gly Thr 
    850                 855                 860                 


Gln Val Pro Gln Phe Leu Phe Ser Ser Ser Asn Phe Ile Tyr Leu Leu 
865                 870                 875                 880 


Phe Thr Thr Asp Asn Ser Arg Ser Asn Asn Gly Phe Lys Ile His Tyr 
                885                 890                 895     


Glu Ser Val Thr Val Asn Thr Tyr Ser Cys Leu Asp Pro Gly Ile Pro 
            900                 905                 910         


Val His Gly Arg Arg Tyr Gly His Asp Phe Ser Ile Gly Ser Thr Val 
        915                 920                 925             


Ser Phe Ser Cys Asp Ser Gly Tyr Arg Leu Ser His Glu Glu Pro Leu 
    930                 935                 940                 


Leu Cys Glu Lys Asn His Trp Trp Ser His Pro Leu Pro Thr Cys Asp 
945                 950                 955                 960 


Ala Leu Cys Gly Gly Asp Val Arg Gly Pro Ser Gly Thr Ile Leu Ser 
                965                 970                 975     


Pro Gly Tyr Pro Glu Phe Tyr Pro Asn Ser Leu Asn Cys Thr Trp Thr 
            980                 985                 990         


Val Asp Val Thr His Gly Lys Gly  Val Gln Phe Asn Phe  His Thr Phe 
        995                 1000                 1005             


His Leu  Glu Asp His His Asp  Tyr Leu Leu Ile Thr  Glu Asn Gly 
    1010                 1015                 1020             


Ser Phe  Thr Gln Pro Leu Ala  Arg Leu Thr Gly Ser  Asp Leu Pro 
    1025                 1030                 1035             


Pro Thr  Ile Asn Ala Gly Leu  Tyr Gly Asn Phe Arg  Ala Gln Leu 
    1040                 1045                 1050             


Arg Phe  Ile Ser Asp Phe Ser  Ile Ser Tyr Glu Gly  Phe Asn Ile 
    1055                 1060                 1065             


Thr Phe  Ser Glu Tyr Asn Leu  Glu Pro Cys Glu Asp  Pro Gly Ile 
    1070                 1075                 1080             


Pro Gln  Tyr Gly Ser Arg Ile  Gly Phe Asn Phe Gly  Ile Gly Asp 
    1085                 1090                 1095             


Thr Leu  Thr Phe Ser Cys Ser  Ser Gly Tyr Arg Leu  Glu Gly Thr 
    1100                 1105                 1110             


Ser Glu  Ile Ile Cys Leu Gly  Gly Gly Arg Arg Val  Trp Ser Ala 
    1115                 1120                 1125             


Pro Leu  Pro Arg Cys Val Ala  Glu Cys Gly Ala Ser  Ala Thr Asn 
    1130                 1135                 1140             


Asn Glu  Gly Ile Leu Leu Ser  Pro Asn Tyr Pro Leu  Asn Tyr Glu 
    1145                 1150                 1155             


Asn Asn  His Glu Cys Ile Tyr  Ser Ile Gln Val Gln  Ala Gly Lys 
    1160                 1165                 1170             


Gly Ile  Asn Ile Ser Ala Arg  Thr Phe His Leu Ala  Gln Gly Asp 
    1175                 1180                 1185             


Val Leu  Lys Ile Tyr Asp Gly  Lys Asp Lys Thr Thr  His Leu Leu 
    1190                 1195                 1200             


Gly Ala  Phe Thr Gly Ala Ser  Met Arg Gly Leu Thr  Leu Ser Ser 
    1205                 1210                 1215             


Thr Ser  Asn Gln Leu Trp Leu  Glu Phe Asn Ser Asp  Thr Glu Gly 
    1220                 1225                 1230             


Thr Asp  Glu Gly Phe Gln Leu  Val Tyr Thr Ser Phe  Glu Leu Ser 
    1235                 1240                 1245             


His Cys  Glu Asp Pro Gly Ile  Pro Gln Phe Gly Tyr  Lys Ile Ser 
    1250                 1255                 1260             


Asp Gln  Gly His Phe Ala Gly  Ser Thr Ile Ile Tyr  Gly Cys Asn 
    1265                 1270                 1275             


Pro Gly  Tyr Thr Leu His Gly  Ser Ser Leu Leu Lys  Cys Met Thr 
    1280                 1285                 1290             


Gly Glu  Arg Arg Ala Trp Asp  Tyr Pro Leu Pro Ser  Cys Ile Ala 
    1295                 1300                 1305             


Glu Cys  Gly Gly Arg Phe Lys  Gly Glu Ser Ser Gly  Arg Ile Leu 
    1310                 1315                 1320             


Ser Pro  Gly Tyr Pro Phe Pro  Tyr Asp Asn Asn Leu  Arg Cys Met 
    1325                 1330                 1335             


Trp Met  Ile Glu Val Asp Pro  Gly Asn Ile Val Ser  Leu Gln Phe 
    1340                 1345                 1350             


Leu Ala  Phe Asp Thr Glu Ala  Ser His Asp Ile Leu  Arg Val Trp 
    1355                 1360                 1365             


Asp Gly  Pro Pro Glu Asn Asp  Met Leu Leu Lys Glu  Ile Ser Gly 
    1370                 1375                 1380             


Ser Leu  Ile Pro Glu Gly Ile  His Ser Thr Leu Asn  Ile Val Thr 
    1385                 1390                 1395             


Ile Gln  Phe Asp Thr Asp Phe  Tyr Ile Ser Lys Ser  Gly Phe Ala 
    1400                 1405                 1410             


Ile Gln  Phe Ser Ser Ser Val  Ala Thr Ala Cys Arg  Asp Pro Gly 
    1415                 1420                 1425             


Val Pro  Met Asn Gly Thr Arg  Asn Gly Asp Gly Arg  Glu Pro Gly 
    1430                 1435                 1440             


Asp Thr  Val Val Phe Gln Cys  Asp Pro Gly Tyr Glu  Leu Gln Gly 
    1445                 1450                 1455             


Glu Glu  Arg Ile Thr Cys Ile  Gln Val Glu Asn Arg  Tyr Phe Trp 
    1460                 1465                 1470             


Gln Pro  Ser Pro Pro Val Cys  Ile Ala Pro Cys Gly  Gly Asn Leu 
    1475                 1480                 1485             


Thr Gly  Ser Ser Gly Phe Ile  Leu Ser Pro Asn Phe  Pro His Pro 
    1490                 1495                 1500             


Tyr Pro  His Ser Arg Asp Cys  Asp Trp Thr Ile Thr  Val Asn Ala 
    1505                 1510                 1515             


Asp Tyr  Val Ile Ser Leu Ala  Phe Ile Ser Phe Ser  Ile Glu Pro 
    1520                 1525                 1530             


Asn Tyr  Asp Phe Leu Tyr Ile  Tyr Asp Gly Pro Asp  Ser Asn Ser 
    1535                 1540                 1545             


Pro Leu  Ile Gly Ser Phe Gln  Asp Ser Lys Leu Pro  Glu Arg Ile 
    1550                 1555                 1560             


Glu Ser  Ser Ser Asn Thr Met  His Leu Ala Phe Arg  Ser Asp Gly 
    1565                 1570                 1575             


Ser Val  Ser Tyr Thr Gly Phe  His Leu Glu Tyr Lys  Ala Lys Leu 
    1580                 1585                 1590             


Arg Glu  Ser Cys Phe Asp Pro  Gly Asn Ile Met Asn  Gly Thr Arg 
    1595                 1600                 1605             


Leu Gly  Met Asp Tyr Lys Leu  Gly Ser Thr Val Thr  Tyr Tyr Cys 
    1610                 1615                 1620             


Asp Ala  Gly Tyr Val Leu Gln  Gly Tyr Ser Thr Leu  Thr Cys Ile 
    1625                 1630                 1635             


Met Gly  Asp Asp Gly Arg Pro  Gly Trp Asn Arg Ala  Leu Pro Ser 
    1640                 1645                 1650             


Cys His  Ala Pro Cys Gly Ser  Arg Ser Thr Gly Ser  Glu Gly Thr 
    1655                 1660                 1665             


Val Leu  Ser Pro Asn Tyr Pro  Lys Asn Tyr Ser Val  Gly His Asn 
    1670                 1675                 1680             


Cys Val  Tyr Ser Ile Ala Val  Pro Lys Glu Phe Val  Val Phe Gly 
    1685                 1690                 1695             


Gln Phe  Val Phe Phe Gln Thr  Ser Leu His Asp Val  Val Glu Val 
    1700                 1705                 1710             


Tyr Asp  Gly Pro Thr Gln Gln  Ser Ser Leu Leu Ser  Ser Leu Ser 
    1715                 1720                 1725             


Gly Ser  His Ser Gly Glu Ser  Leu Pro Leu Ser Ser  Gly Asn Gln 
    1730                 1735                 1740             


Ile Thr  Ile Arg Phe Thr Ser  Val Gly Pro Ile Thr  Ala Lys Gly 
    1745                 1750                 1755             


Phe His  Phe Val Tyr Gln Ala  Val Pro Arg Thr Ser  Ser Thr Gln 
    1760                 1765                 1770             


Cys Ser  Ser Val Pro Glu Pro  Arg Phe Gly Arg Arg  Ile Gly Asn 
    1775                 1780                 1785             


Glu Phe  Ala Val Gly Ser Ser  Val Leu Phe Asp Cys  Asn Pro Gly 
    1790                 1795                 1800             


Tyr Ile  Leu His Gly Ser Ile  Ala Ile Arg Cys Glu  Thr Val Pro 
    1805                 1810                 1815             


Asn Ser  Leu Ala Gln Trp Asn  Asp Ser Leu Pro Thr  Cys Ile Val 
    1820                 1825                 1830             


Pro Cys  Gly Gly Ile Leu Thr  Lys Arg Lys Gly Thr  Ile Leu Ser 
    1835                 1840                 1845             


Pro Gly  Tyr Pro Glu Pro Tyr  Asp Asn Asn Leu Asn  Cys Val Trp 
    1850                 1855                 1860             


Lys Ile  Thr Val Pro Glu Gly  Ala Gly Ile Gln Val  Gln Val Val 
    1865                 1870                 1875             


Ser Phe  Ala Thr Glu His Asn  Trp Asp Ser Leu Asp  Phe Tyr Asp 
    1880                 1885                 1890             


Gly Gly  Asp Asn Asn Ala Pro  Arg Leu Gly Ser Tyr  Ser Gly Thr 
    1895                 1900                 1905             


Thr Ile  Pro His Leu Leu Asn  Ser Thr Ser Asn Asn  Leu Tyr Leu 
    1910                 1915                 1920             


Asn Phe  Gln Ser Asp Ile Ser  Val Ser Ala Ala Gly  Phe His Leu 
    1925                 1930                 1935             


Glu Tyr  Thr Ala Ile Gly Leu  Asp Ser Cys Pro Glu  Pro Gln Thr 
    1940                 1945                 1950             


Pro Ser  Ser Gly Ile Lys Ile  Gly Asp Arg Tyr Met  Val Gly Asp 
    1955                 1960                 1965             


Val Val  Ser Phe Gln Cys Asp  Gln Gly Tyr Ser Leu  Gln Gly His 
    1970                 1975                 1980             


Ser His  Ile Thr Cys Met Pro  Gly Pro Val Arg Arg  Trp Asn Tyr 
    1985                 1990                 1995             


Pro Ile  Pro Ile Cys Leu Ala  Gln Cys Gly Gly Ala  Met Ser Asp 
    2000                 2005                 2010             


Phe Ser  Gly Val Ile Leu Ser  Pro Gly Phe Pro Gly  Asn Tyr Pro 
    2015                 2020                 2025             


Ser Ser  Leu Asp Cys Thr Trp  Thr Ile Asn Leu Pro  Ile Gly Phe 
    2030                 2035                 2040             


Gly Val  His Leu Gln Phe Val  Asn Phe Ser Thr Glu  Thr Ile His 
    2045                 2050                 2055             


Asp Tyr  Leu Glu Val Arg Ser  Gly Ser Ser Glu Thr  Ser Thr Val 
    2060                 2065                 2070             


Ile Gly  Arg Leu Ser Gly Pro  Gln Ile Pro Ser Ser  Leu Phe Ser 
    2075                 2080                 2085             


Thr Thr  His Glu Thr Ser Leu  Tyr Phe His Ser Asp  Tyr Ser Gln 
    2090                 2095                 2100             


Asn Lys  Gln Gly Phe His Ile  Val Tyr Gln Ala Tyr  Gln Leu Gln 
    2105                 2110                 2115             


Ser Cys  Pro Asp Pro Arg Pro  Phe Arg Asn Gly Phe  Val Ile Gly 
    2120                 2125                 2130             


Asn Asp  Phe Thr Val Gly Gln  Thr Ile Ser Phe Glu  Cys Phe Pro 
    2135                 2140                 2145             


Gly Tyr  Thr Leu Ile Gly Asn  Ser Ala Leu Thr Cys  Leu His Gly 
    2150                 2155                 2160             


Val Ser  Arg Asn Trp Asn His  Pro Leu Pro Arg Cys  Glu Ala Leu 
    2165                 2170                 2175             


Cys Gly  Gly Asn Ile Thr Ala  Met Asn Gly Thr Ile  Tyr Ser Pro 
    2180                 2185                 2190             


Gly Tyr  Pro Asp Glu Tyr Pro  Asn Phe Gln Asp Cys  Phe Trp Leu 
    2195                 2200                 2205             


Val Arg  Val Pro Pro Gly Asn  Gly Ile Tyr Ile Asn  Phe Thr Val 
    2210                 2215                 2220             


Leu Gln  Thr Glu Pro Ile Tyr  Asp Phe Ile Thr Val  Trp Asp Gly 
    2225                 2230                 2235             


Pro Asp  Gln Asn Ser Pro Gln  Ile Gly Gln Phe Ser  Gly Asn Thr 
    2240                 2245                 2250             


Ala Leu  Glu Ser Val Tyr Ser  Thr Ser Asn Gln Ile  Leu Ile Lys 
    2255                 2260                 2265             


Phe His  Ser Asp Phe Thr Thr  Ser Gly Phe Phe Val  Leu Ser Tyr 
    2270                 2275                 2280             


His Ala  Tyr Gln Leu Arg Val  Cys Gln Pro Pro Pro  Pro Val Pro 
    2285                 2290                 2295             


Asn Ala  Glu Ile Leu Thr Glu  Asp Asp Glu Phe Glu  Ile Gly Asp 
    2300                 2305                 2310             


Ile Ile  Arg Tyr Gln Cys Leu  Pro Gly Phe Thr Leu  Val Gly Asn 
    2315                 2320                 2325             


Ala Ile  Leu Thr Cys Arg Leu  Gly Glu Arg Leu Gln  Met Asp Gly 
    2330                 2335                 2340             


Ala Pro  Pro Val Cys Gln Val  Leu Cys Pro Ala Asn  Glu Leu Arg 
    2345                 2350                 2355             


Leu Asp  Ser Thr Gly Val Ile  Leu Ser Pro Gly Tyr  Pro Asp Ser 
    2360                 2365                 2370             


Tyr Pro  Asn Leu Gln Met Cys  Ala Trp Ser Ile Ser  Val Glu Lys 
    2375                 2380                 2385             


Gly Tyr  Asn Ile Thr Met Phe  Val Glu Phe Phe Gln  Thr Glu Lys 
    2390                 2395                 2400             


Glu Phe  Asp Val Leu Gln Val  Tyr Asp Gly Pro Asn  Ile Gln Ser 
    2405                 2410                 2415             


Pro Val  Leu Ile Ser Leu Ser  Gly Asp Tyr Ser Ser  Ala Phe Asn 
    2420                 2425                 2430             


Ile Thr  Ser Asn Gly His Glu  Val Phe Leu Gln Trp  Ser Ala Asp 
    2435                 2440                 2445             


His Gly  Asn Asn Lys Lys Gly  Phe Arg Ile Arg Tyr  Ile Ala Phe 
    2450                 2455                 2460             


Tyr Cys  Ser Thr Pro Glu Ser  Pro Pro His Gly Tyr  Ile Ile Ser 
    2465                 2470                 2475             


Gln Thr  Gly Gly Gln Leu Asn  Ser Val Val Arg Trp  Ala Cys Asp 
    2480                 2485                 2490             


Arg Gly  Phe Arg Leu Val Gly  Lys Ser Ser Ala Val  Cys Arg Lys 
    2495                 2500                 2505             


Ser Ser  Tyr Gly Tyr His Ala  Trp Asp Ala Pro Val  Pro Ala Cys 
    2510                 2515                 2520             


Gln Ala  Ile Ser Cys Gly Ile  Pro Lys Ala Pro Thr  Asn Gly Gly 
    2525                 2530                 2535             


Ile Leu  Thr Thr Asp Tyr Leu  Val Gly Thr Arg Val  Thr Tyr Phe 
    2540                 2545                 2550             


Cys Asn  Asp Gly Tyr Arg Leu  Ser Ser Lys Glu Leu  Thr Thr Ala 
    2555                 2560                 2565             


Val Cys  Gln Ser Asp Gly Thr  Trp Ser Asn His Asn  Lys Thr Pro 
    2570                 2575                 2580             


Arg Cys  Val Val Ile Ser Cys  Gly Glu Leu Pro Thr  Pro Pro Asn 
    2585                 2590                 2595             


Gly Asn  Lys Ile Gly Thr Gln  Thr Ser Tyr Gly Ser  Thr Ala Ile 
    2600                 2605                 2610             


Phe Thr  Cys Asp Leu Gly Phe  Met Leu Val Gly Ser  Ala Val Arg 
    2615                 2620                 2625             


Glu Cys  Leu Ser Ser Gly Leu  Trp Ser Glu Ser Glu  Thr Arg Cys 
    2630                 2635                 2640             


Leu Ala  Gly His Cys Gly Ile  Pro Glu Leu Ile Val  Asn Gly Gln 
    2645                 2650                 2655             


Val Ile  Gly Glu Asn Tyr Gly  Tyr Arg Asp Thr Val  Val Tyr Gln 
    2660                 2665                 2670             


Cys Asn  Pro Gly Phe Arg Leu  Ile Gly Ser Ser Val  Arg Ile Cys 
    2675                 2680                 2685             


Gln Gln  Asp His Asn Trp Ser  Gly Gln Leu Pro Ser  Cys Val Pro 
    2690                 2695                 2700             


Val Ser  Cys Gly His Pro Gly  Ser Pro Ile Tyr Gly  Arg Thr Ser 
    2705                 2710                 2715             


Gly Asn  Gly Phe Asn Phe Asn  Asp Val Val Thr Phe  Ser Cys Asn 
    2720                 2725                 2730             


Ile Gly  Tyr Leu Met Gln Gly  Pro Thr Lys Ala Gln  Cys Gln Ala 
    2735                 2740                 2745             


Asn Arg  Gln Trp Ser His Pro  Pro Pro Met Cys Lys  Val Val Asn 
    2750                 2755                 2760             


Cys Ser  Asp Pro Gly Ile Pro  Ala Asn Ser Lys Arg  Glu Ser Lys 
    2765                 2770                 2775             


Ile Glu  His Gly Asn Phe Thr  Tyr Gly Thr Val Val  Phe Tyr Asp 
    2780                 2785                 2790             


Cys Asn  Pro Gly Tyr Phe Leu  Phe Gly Ser Ser Val  Leu Ile Cys 
    2795                 2800                 2805             


Gln Pro  Asn Gly Gln Trp Asp  Lys Pro Leu Pro Glu  Cys Ile Met 
    2810                 2815                 2820             


Ile Asp  Cys Gly His Pro Gly  Val Pro Pro Asn Ala  Val Leu Ser 
    2825                 2830                 2835             


Gly Glu  Lys Tyr Thr Phe Gly  Ser Thr Val His Tyr  Ser Cys Thr 
    2840                 2845                 2850             


Gly Lys  Arg Ser Leu Leu Gly  Gln Ser Ser Arg Thr  Cys Gln Leu 
    2855                 2860                 2865             


Asn Gly  His Trp Ser Gly Ser  Gln Pro His Cys Ser  Gly Asp Ala 
    2870                 2875                 2880             


Thr Gly  Thr Cys Gly Asp Pro  Gly Thr Pro Gly His  Gly Ser Arg 
    2885                 2890                 2895             


Gln Glu  Ser Asn Phe Arg Thr  Lys Ser Thr Val Arg  Tyr Ala Cys 
    2900                 2905                 2910             


Asp Thr  Gly Tyr Ile Leu His  Gly Ser Glu Glu Arg  Thr Cys Leu 
    2915                 2920                 2925             


Ala Asn  Gly Ser Trp Thr Gly  Arg Gln Pro Glu Cys  Lys Ala Val 
    2930                 2935                 2940             


Gln Cys  Gly Asn Pro Gly Thr  Thr Ala Asn Gly Lys  Val Phe Arg 
    2945                 2950                 2955             


Ile Asp  Gly Thr Thr Phe Ser  Ser Ser Val Ile Tyr  Ser Cys Met 
    2960                 2965                 2970             


Glu Gly  Tyr Ile Leu Ser Gly  Pro Ser Val Arg Gln  Cys Thr Ala 
    2975                 2980                 2985             


Asn Gly  Thr Trp Ser Gly Thr  Leu Pro Asn Cys Thr  Ile Ile Ser 
    2990                 2995                 3000             


Cys Gly  Asp Pro Gly Ile Pro  Ala Asn Gly Leu Arg  Tyr Gly Asp 
    3005                 3010                 3015             


Asp Tyr  Val Val Gly Gln Asn  Val Ser Tyr Met Cys  Gln Pro Gly 
    3020                 3025                 3030             


Tyr Thr  Met Glu Leu Asn Gly  Ser Arg Ile Arg Thr  Cys Thr Ile 
    3035                 3040                 3045             


Asn Gly  Thr Trp Ser Gly Val  Met Pro Thr Cys Arg  Ala Val Thr 
    3050                 3055                 3060             


Cys Pro  Thr Pro Pro Gln Ile  Ser Asn Gly Arg Leu  Glu Gly Thr 
    3065                 3070                 3075             


Asn Phe  Asp Trp Gly Phe Ser  Ile Ser Tyr Ile Cys  Ser Pro Gly 
    3080                 3085                 3090             


Tyr Glu  Leu Ser Phe Pro Ala  Val Leu Thr Cys Val  Gly Asn Gly 
    3095                 3100                 3105             


Thr Trp  Ser Gly Glu Val Pro  Gln Cys Leu Pro Lys  Phe Cys Gly 
    3110                 3115                 3120             


Asp Pro  Gly Ile Pro Ala Gln  Gly Lys Arg Glu Gly  Lys Ser Phe 
    3125                 3130                 3135             


Ile Tyr  Gln Ser Glu Val Ser  Phe Ser Cys Asn Phe  Pro Phe Ile 
    3140                 3145                 3150             


Leu Val  Gly Ser Ser Thr Arg  Ile Cys Gln Ala Asp  Gly Thr Trp 
    3155                 3160                 3165             


Ser Gly  Ser Ser Pro His Cys  Ile Glu Pro Thr Gln  Thr Ser Cys 
    3170                 3175                 3180             


Glu Asn  Pro Gly Val Pro Arg  His Gly Ser Gln Asn  Asn Thr Phe 
    3185                 3190                 3195             


Gly Phe  Gln Val Gly Ser Val  Val Gln Phe His Cys  Lys Lys Gly 
    3200                 3205                 3210             


His Leu  Leu Gln Gly Ser Thr  Thr Arg Thr Cys Leu  Pro Asp Leu 
    3215                 3220                 3225             


Thr Trp  Ser Gly Ile Gln Pro  Glu Cys Ile Pro His  Ser Cys Lys 
    3230                 3235                 3240             


Gln Pro  Glu Thr Pro Ala His  Ala Asn Val Val Gly  Met Asp Leu 
    3245                 3250                 3255             


Pro Ser  His Gly Tyr Thr Leu  Ile Tyr Thr Cys Gln  Pro Gly Phe 
    3260                 3265                 3270             


Phe Leu  Ala Gly Gly Thr Glu  His Arg Val Cys Arg  Ser Asp Asn 
    3275                 3280                 3285             


Thr Trp  Thr Gly Lys Val Pro  Ile Cys Glu Ala Gly  Ser Lys Ile 
    3290                 3295                 3300             


Leu Val  Lys Asp Pro Arg Pro  Ala Leu Gly Thr Pro  Ser Pro Lys 
    3305                 3310                 3315             


Leu Ser  Val Pro Asp Asp Val  Phe Ala Gln Asn Tyr  Ile Trp Lys 
    3320                 3325                 3330             


Gly Ser  Tyr Asn Phe Lys Gly  Arg Lys Gln Pro Met  Thr Leu Thr 
    3335                 3340                 3345             


Val Thr  Ser Phe Asn Ala Ser  Thr Gly Arg Val Asn  Ala Thr Leu 
    3350                 3355                 3360             


Ser Asn  Ser Asn Met Glu Leu  Leu Leu Ser Gly Val  Tyr Lys Ser 
    3365                 3370                 3375             


Gln Glu  Ala Arg Leu Met Leu  Arg Ile Tyr Leu Ile  Lys Val Pro 
    3380                 3385                 3390             


Ala His  Ala Ser Val Lys Lys  Met Lys Glu Glu Asn  Trp Ala Met 
    3395                 3400                 3405             


Asp Gly  Phe Val Ser Ala Glu  Pro Asp Gly Ala Thr  Tyr Val Phe 
    3410                 3415                 3420             


Gln Gly  Phe Ile Gln Gly Lys  Asp Tyr Gly Gln Phe  Gly Leu Gln 
    3425                 3430                 3435             


Arg Leu  Gly Leu Asn Met Ser  Glu Gly Ser Asn Ser  Ser Asn Gln 
    3440                 3445                 3450             


Pro His  Gly Thr Asn Ser Ser  Ser Val Ala Ile Ala  Ile Leu Val 
    3455                 3460                 3465             


Pro Phe  Phe Ala Leu Ile Phe  Ala Gly Phe Gly Phe  Tyr Leu Tyr 
    3470                 3475                 3480             


Lys Gln  Arg Thr Ala Pro Lys  Thr Gln Tyr Thr Gly  Cys Ser Val 
    3485                 3490                 3495             


His Glu  Asn Asn Asn Gly Gln  Ala Ala Phe Glu Asn  Pro Met Tyr 
    3500                 3505                 3510             


Asp Thr  Asn Ala Lys Ser Val  Glu Gly Lys Ala Val  Arg Phe Asp 
    3515                 3520                 3525             


Pro Asn  Leu Asn Thr Val Cys  Thr Met Val 
    3530                 3535             


<210>  5533
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  5533

Met Leu Cys Leu Cys Leu Tyr Val Pro Val Ile Gly Glu Ala Gln Thr 
1               5                   10                  15      


Glu Phe Gln Tyr Phe Glu Ser Lys Gly Leu Pro Ala Glu Leu Lys Ser 
            20                  25                  30          


Ile Phe Lys Leu Ser Val Phe Ile Pro Ser Gln Glu Phe Ser Thr Tyr 
        35                  40                  45              


Arg Gln Trp Lys Gln Lys Ile Val Gln Ala Gly Asp Lys Asp Leu Asp 
    50                  55                  60                  


Gly Gln Leu Asp Phe Glu Glu Phe Val His Tyr Leu Gln Asp His Glu 
65                  70                  75                  80  


Lys Lys Leu Arg Leu Val Phe Lys Ser Leu Asp Lys Lys Asn Asp Gly 
                85                  90                  95      


Arg Ile Asp Ala Gln Glu Ile Met Gln Ser Leu Arg Asp Leu Gly Val 
            100                 105                 110         


Lys Ile Ser Glu Gln Gln Ala Glu Lys Ile Leu Lys Ser Met Asp Lys 
        115                 120                 125             


Asn Gly Thr Met Thr Ile Asp Trp Asn Glu Trp Arg Asp Tyr His Leu 
    130                 135                 140                 


Leu His Pro Val Glu Asn Ile Pro Glu Ile Ile Leu Tyr Trp Lys His 
145                 150                 155                 160 


Ser Thr Ile Phe Asp Val Gly Glu Asn Leu Thr Val Pro Asp Glu Phe 
                165                 170                 175     


Thr Val Glu Glu Arg Gln Thr Gly Met Trp Trp Arg His Leu Val Ala 
            180                 185                 190         


Gly Gly Gly Ala Gly Ala Val Ser Arg Thr Cys Thr Ala Pro Leu Asp 
        195                 200                 205             


Arg Leu Lys Val Leu Met Gln Val His Ala Ser Arg Ser Asn Asn Met 
    210                 215                 220                 


Gly Ile Val Gly Gly Phe Thr Gln Met Ile Arg Glu Gly Gly Ala Arg 
225                 230                 235                 240 


Ser Leu Trp Arg Gly Asn Gly Ile Asn Val Leu Lys Ile Ala Pro Glu 
                245                 250                 255     


Ser Ala Ile Lys Phe Met Ala Tyr Glu Gln Ile Lys Arg Leu Val Gly 
            260                 265                 270         


Ser Asp Gln Glu Thr Leu Arg Ile His Glu Arg Leu Val Ala Gly Ser 
        275                 280                 285             


Leu Ala Gly Ala Ile Ala Gln Ser Ser Ile Tyr Pro Met Glu Val Leu 
    290                 295                 300                 


Lys Thr Arg Met Ala Leu Arg Lys Thr Gly Gln Tyr Ser Gly Met Leu 
305                 310                 315                 320 


Asp Cys Ala Arg Arg Ile Leu Ala Arg Glu Gly Val Ala Ala Phe Tyr 
                325                 330                 335     


Lys Gly Tyr Val Pro Asn Met Leu Gly Ile Ile Pro Tyr Ala Gly Ile 
            340                 345                 350         


Asp Leu Ala Val Tyr Glu Thr Leu Lys Asn Ala Trp Leu Gln His Tyr 
        355                 360                 365             


Ala Val Asn Ser Ala Asp Pro Gly Val Phe Val Leu Leu Ala Cys Gly 
    370                 375                 380                 


Thr Met Ser Ser Thr Cys Gly Gln Leu Ala Ser Tyr Pro Leu Ala Leu 
385                 390                 395                 400 


Val Arg Thr Arg Met Gln Ala Gln Ala Ser Ile Glu Gly Ala Pro Glu 
                405                 410                 415     


Val Thr Met Ser Ser Leu Phe Lys His Ile Leu Arg Thr Glu Gly Ala 
            420                 425                 430         


Phe Gly Leu Tyr Arg Gly Leu Ala Pro Asn Phe Met Lys Val Ile Pro 
        435                 440                 445             


Ala Val Ser Ile Ser Tyr Val Val Tyr Glu Asn Leu Lys Ile Thr Leu 
    450                 455                 460                 


Gly Val Gln Ser Arg 
465                 


<210>  5534
<211>  820
<212>  PRT
<213>  Homo sapiens

<400>  5534

Met Leu Arg Leu Gly Leu Cys Ala Ala Ala Leu Leu Cys Val Cys Arg 
1               5                   10                  15      


Pro Gly Ala Val Arg Ala Asp Cys Trp Leu Ile Glu Gly Asp Lys Gly 
            20                  25                  30          


Tyr Val Trp Leu Ala Ile Cys Ser Gln Asn Gln Pro Pro Tyr Glu Thr 
        35                  40                  45              


Ile Pro Gln His Ile Asn Ser Thr Val His Asp Leu Arg Leu Asn Glu 
    50                  55                  60                  


Asn Lys Leu Lys Ala Val Leu Tyr Ser Ser Leu Asn Arg Phe Gly Asn 
65                  70                  75                  80  


Leu Thr Asp Leu Asn Leu Thr Lys Asn Glu Ile Ser Tyr Ile Glu Asp 
                85                  90                  95      


Gly Ala Phe Leu Gly Gln Ser Ser Leu Gln Val Leu Gln Leu Gly Tyr 
            100                 105                 110         


Asn Lys Leu Ser Asn Leu Thr Glu Gly Met Leu Arg Gly Met Ser Arg 
        115                 120                 125             


Leu Gln Phe Leu Phe Val Gln His Asn Leu Ile Glu Val Val Thr Pro 
    130                 135                 140                 


Thr Ala Phe Ser Glu Cys Pro Ser Leu Ile Ser Ile Asp Leu Ser Ser 
145                 150                 155                 160 


Asn Arg Leu Ser Arg Leu Asp Gly Ala Thr Phe Ala Ser Leu Ala Ser 
                165                 170                 175     


Leu Met Val Cys Glu Leu Ala Gly Asn Pro Phe Asn Cys Glu Cys Asp 
            180                 185                 190         


Leu Phe Gly Phe Leu Ala Trp Leu Val Val Phe Asn Asn Val Thr Lys 
        195                 200                 205             


Asn Tyr Asp Arg Leu Gln Cys Glu Ser Pro Arg Glu Phe Ala Gly Tyr 
    210                 215                 220                 


Pro Leu Leu Val Pro Arg Pro Tyr His Ser Leu Asn Ala Ile Thr Val 
225                 230                 235                 240 


Leu Gln Ala Lys Cys Arg Asn Gly Ser Leu Pro Ala Arg Pro Val Ser 
                245                 250                 255     


His Pro Thr Pro Tyr Ser Thr Asp Ala Gln Arg Glu Pro Asp Glu Asn 
            260                 265                 270         


Ser Gly Phe Asn Pro Asp Glu Ile Leu Ser Val Glu Pro Pro Ala Ser 
        275                 280                 285             


Ser Thr Thr Asp Ala Ser Ala Gly Pro Ala Ile Lys Leu His His Val 
    290                 295                 300                 


Thr Phe Thr Ser Ala Thr Leu Val Val Ile Ile Pro His Pro Tyr Ser 
305                 310                 315                 320 


Lys Met Tyr Ile Leu Val Gln Tyr Asn Asn Ser Tyr Phe Ser Asp Val 
                325                 330                 335     


Met Thr Leu Lys Asn Lys Lys Glu Ile Val Thr Leu Asp Lys Leu Arg 
            340                 345                 350         


Ala His Thr Glu Tyr Thr Phe Cys Val Thr Ser Leu Arg Asn Ser Arg 
        355                 360                 365             


Arg Phe Asn His Thr Cys Leu Thr Phe Thr Thr Arg Asp Pro Val Pro 
    370                 375                 380                 


Gly Asp Leu Ala Pro Ser Thr Ser Thr Thr Thr His Tyr Ile Met Thr 
385                 390                 395                 400 


Ile Leu Gly Cys Leu Phe Gly Met Val Ile Val Leu Gly Ala Val Tyr 
                405                 410                 415     


Tyr Cys Leu Arg Lys Arg Arg Met Gln Glu Glu Lys Gln Lys Ser Val 
            420                 425                 430         


Asn Val Lys Lys Thr Ile Leu Glu Met Arg Tyr Gly Ala Asp Val Asp 
        435                 440                 445             


Ala Gly Ser Ile Val His Ala Ala Gln Lys Leu Gly Glu Pro Pro Val 
    450                 455                 460                 


Leu Pro Val Ser Arg Met Ala Ser Ile Pro Ser Met Ile Gly Glu Lys 
465                 470                 475                 480 


Leu Pro Thr Ala Lys Gly Leu Glu Ala Gly Leu Asp Thr Pro Lys Val 
                485                 490                 495     


Ala Thr Lys Gly Asn Tyr Ile Glu Val Arg Thr Gly Ala Gly Gly Asp 
            500                 505                 510         


Gly Leu Ala Arg Pro Glu Asp Asp Leu Pro Asp Leu Glu Asn Gly Gln 
        515                 520                 525             


Gly Ser Ala Ala Glu Ile Ser Thr Ile Ala Lys Glu Val Asp Lys Val 
    530                 535                 540                 


Asn Gln Ile Ile Asn Asn Cys Ile Asp Ala Leu Lys Leu Asp Ser Ala 
545                 550                 555                 560 


Ser Phe Leu Gly Gly Gly Ser Ser Ser Gly Asp Pro Glu Leu Ala Phe 
                565                 570                 575     


Glu Cys Gln Ser Leu Pro Ala Ala Ala Ala Ala Ser Ser Ala Thr Gly 
            580                 585                 590         


Pro Gly Ala Leu Glu Arg Pro Ser Phe Leu Ser Pro Pro Tyr Lys Glu 
        595                 600                 605             


Ser Ser His His Pro Leu Gln Arg Gln Leu Ser Ala Asp Ala Ala Val 
    610                 615                 620                 


Thr Arg Lys Thr Cys Ser Val Ser Ser Ser Gly Ser Ile Lys Ser Ala 
625                 630                 635                 640 


Lys Val Phe Ser Leu Asp Val Pro Asp His Pro Ala Ala Thr Gly Leu 
                645                 650                 655     


Ala Lys Gly Asp Ser Lys Tyr Ile Glu Lys Gly Ser Pro Leu Asn Ser 
            660                 665                 670         


Pro Leu Asp Arg Leu Pro Leu Val Pro Ala Gly Ser Gly Gly Gly Ser 
        675                 680                 685             


Gly Gly Gly Gly Gly Ile His His Leu Glu Val Lys Pro Ala Tyr His 
    690                 695                 700                 


Cys Ser Glu His Arg His Ser Phe Pro Ala Leu Tyr Tyr Glu Glu Gly 
705                 710                 715                 720 


Ala Asp Ser Leu Ser Gln Arg Val Ser Phe Leu Lys Pro Leu Thr Arg 
                725                 730                 735     


Ser Lys Arg Asp Ser Thr Tyr Ser Gln Leu Ser Pro Arg His Tyr Tyr 
            740                 745                 750         


Ser Gly Tyr Ser Ser Ser Pro Glu Tyr Ser Ser Glu Ser Thr His Lys 
        755                 760                 765             


Ile Trp Glu Arg Phe Arg Pro Tyr Lys Lys His His Arg Glu Glu Val 
    770                 775                 780                 


Tyr Met Ala Ala Gly His Ala Leu Arg Lys Lys Val Gln Phe Ala Lys 
785                 790                 795                 800 


Asp Glu Asp Leu His Asp Ile Leu Asp Tyr Trp Lys Gly Val Ser Ala 
                805                 810                 815     


Gln Gln Lys Leu 
            820 


<210>  5535
<211>  1078
<212>  PRT
<213>  Homo sapiens

<400>  5535

Met Phe Gly Ala Ala Ser Arg Met Asp Thr Thr Ala Val Cys Thr Gly 
1               5                   10                  15      


Gly Val Thr Glu Ser Arg Gly Ile Val Asp Ser Leu Gln Lys Phe Ser 
            20                  25                  30          


Ser Leu Pro Ala Tyr Leu Pro Thr Asn Leu His Ile Ser Asn Ala Glu 
        35                  40                  45              


Glu Ser Phe Phe Leu Lys Glu Ala Asn Gln Asp Leu Thr Arg Asn Ser 
    50                  55                  60                  


Ser Leu Gln Ala Arg Val Glu Pro Phe Phe Ile Tyr Arg Ala Arg Thr 
65                  70                  75                  80  


Pro Pro Ile Ile Asn Ala Ser Tyr Gly Pro Phe Ser Val Glu Lys Ile 
                85                  90                  95      


Ile Pro Gln Glu Leu Leu Leu Thr Ser Thr Ala Phe Gly Asn Met Asp 
            100                 105                 110         


Lys Phe Pro Phe Asn Trp Lys Leu Lys Ser His Ile Leu Asp Ser Ser 
        115                 120                 125             


Ile Tyr Ser Asn Arg Pro Lys Val Gln Thr Leu Phe Tyr Val Thr Gly 
    130                 135                 140                 


Met Gly Trp Asp Asp Ser Asp Leu Thr Glu Asp Leu Pro Cys Val Lys 
145                 150                 155                 160 


Met Phe Ala Phe Pro Glu Ala Arg Glu Val Ala Ala Ser Cys Arg Leu 
                165                 170                 175     


Gln Gly Ala Pro Gly Leu Cys Val Ala Glu Leu Glu Leu Leu Pro Glu 
            180                 185                 190         


Trp Phe Ser Ser Gly Leu Asp Leu Glu Pro Glu Glu Glu Ile Pro Ala 
        195                 200                 205             


Leu Leu Gly Gly Thr Thr Met Glu Leu Phe Phe Thr Leu Tyr Pro Ala 
    210                 215                 220                 


Asp Lys Ala Gly Gln Cys Pro Leu Glu Glu Glu Gly Lys Trp Glu Asn 
225                 230                 235                 240 


Asn Ile His Ser Gly Leu Glu Ser Pro Gln Gln Ala Phe Pro Ala Arg 
                245                 250                 255     


Glu Arg Ile Gly Ser Val Val Val Tyr Pro Thr Gln Asp Asp Leu Lys 
            260                 265                 270         


Trp Ser Leu Val Ser Leu Asp Glu Asn Val Val Ile Ser Val Pro Leu 
        275                 280                 285             


Asn Leu Val Arg Glu Gly Asp Thr Ala Thr Phe Leu Val Ser Leu Thr 
    290                 295                 300                 


Ser Ser Ser Val Ala Asp Gln Phe Thr Leu Arg Ile Lys Ala Ala Ala 
305                 310                 315                 320 


Gly Val Lys Ile Thr Ala Val Arg Val Ser Ser Glu Asp Gln Trp Ala 
                325                 330                 335     


Val Gln Glu Glu Ile Asp Asn Gly Ser Thr Gln Thr Ser Ala Thr Leu 
            340                 345                 350         


Thr Cys Met Gly His Arg Pro Asp Thr Gln Ser Arg Val Asn Gly Ser 
        355                 360                 365             


Phe Tyr Glu Ile Leu Gln Val Asp Phe Gly Ile Asp Asn Ser Ser Asp 
    370                 375                 380                 


Leu Ala Gly Ala Gln Gln Ile Thr Trp Gln Val Glu Tyr Pro Ile Glu 
385                 390                 395                 400 


Asp Ser Met Ser Glu Leu Val Val Ser Glu Ile Phe Val Ser Gln Thr 
                405                 410                 415     


Thr Phe Val Gly Ile Val Pro Leu Ala Met Asp Thr Glu Val Leu Asn 
            420                 425                 430         


Thr Ala Ile Leu Thr Gly Lys Pro Val Ser Val Pro Val Lys Val Val 
        435                 440                 445             


Gly Val Gln Glu Asp Gly Ser Val Val Asp Val Ser Glu Ser Val Glu 
    450                 455                 460                 


Cys Lys Ser Ala Asp Glu Asp Val Ile Lys Val Ser Asn Asn Cys Asp 
465                 470                 475                 480 


Ser Ile Phe Val Asn Gly Lys Glu Met Lys Ser Lys Val Asp Thr Ile 
                485                 490                 495     


Val Asn Phe Thr His Gln His Phe Thr Ser Gln Phe Glu Val Thr Val 
            500                 505                 510         


Trp Ala Pro Arg Leu Pro Leu Gln Ile Glu Ile Ser Asp Thr Glu Leu 
        515                 520                 525             


Ser Gln Ile Lys Gly Trp Arg Ile Pro Val Ala Ala Asn Arg Arg Pro 
    530                 535                 540                 


Thr Arg Glu Ser Asp Asp Glu Asp Asp Glu Glu Lys Lys Gly Arg Gly 
545                 550                 555                 560 


Cys Ser Leu Gln Tyr Gln His Ala Thr Val Arg Val Leu Thr Gln Phe 
                565                 570                 575     


Val Ala Glu Ser Pro Asp Leu Gly Gln Leu Thr Tyr Met Leu Gly Pro 
            580                 585                 590         


Asp Trp Gln Phe Asp Ile Thr Asp Leu Val Thr Glu Phe Met Lys Val 
        595                 600                 605             


Glu Glu Pro Lys Ile Ala Gln Leu Gln Asp Gly Arg Thr Leu Ala Gly 
    610                 615                 620                 


Arg Glu Pro Gly Ile Thr Thr Val Gln Val Leu Ser Pro Leu Ser Asp 
625                 630                 635                 640 


Ser Ile Leu Ala Glu Lys Thr Val Ile Val Leu Asp Asp Arg Val Thr 
                645                 650                 655     


Ile Ala Glu Leu Gly Val Gln Leu Val Ala Gly Met Ser Leu Ser Leu 
            660                 665                 670         


Gln Pro His Arg Ala Asp Lys Arg Ala Ile Val Ser Thr Ala Ala Ala 
        675                 680                 685             


Leu Asp Val Leu Gln Ser Pro Gln Gln Glu Ala Ile Val Ser Ser Trp 
    690                 695                 700                 


Ile Leu Phe Ser Asp Gly Ser Val Thr Pro Leu Asp Ile Tyr Asp Pro 
705                 710                 715                 720 


Lys Asp Tyr Ser Val Thr Val Ser Ser Leu Asp Glu Met Val Val Ser 
                725                 730                 735     


Val Gln Ala Asn Leu Glu Ser Lys Trp Pro Ile Val Val Ala Glu Gly 
            740                 745                 750         


Glu Gly Gln Gly Pro Leu Ile Lys Leu Glu Met Met Ile Ser Glu Pro 
        755                 760                 765             


Cys Gln Lys Thr Lys Arg Lys Ser Val Leu Ala Val Gly Lys Gly Asn 
    770                 775                 780                 


Val Lys Val Lys Phe Glu Pro Ser Ser Asp Glu His Gln Gly Gly Ser 
785                 790                 795                 800 


Asn Asp Ile Glu Gly Ile Asn Arg Glu Tyr Lys Asp His Leu Ser Asn 
                805                 810                 815     


Ser Ile Glu Arg Glu Gly Asn Gln Glu Arg Ala Val Gln Glu Trp Phe 
            820                 825                 830         


His Arg Gly Thr Pro Val Gly Gln Glu Glu Ser Thr Asn Lys Ser Thr 
        835                 840                 845             


Thr Pro Gln Ser Pro Met Glu Gly Lys Asn Lys Leu Leu Lys Ser Gly 
    850                 855                 860                 


Gly Pro Asp Ala Phe Thr Ser Phe Pro Thr Gln Gly Lys Ser Pro Asp 
865                 870                 875                 880 


Pro Asn Asn Pro Ser Asp Leu Thr Val Thr Ser Arg Gly Leu Thr Asp 
                885                 890                 895     


Leu Glu Ile Gly Met Tyr Ala Leu Leu Cys Val Phe Cys Leu Ala Ile 
            900                 905                 910         


Leu Val Phe Leu Ile Asn Cys Val Ala Phe Ala Trp Lys Tyr Arg His 
        915                 920                 925             


Lys Arg Phe Ala Val Ser Glu Gln Gly Asn Ile Pro His Ser His Asp 
    930                 935                 940                 


Trp Val Trp Leu Gly Asn Glu Val Glu Leu Leu Glu Asn Pro Val Asp 
945                 950                 955                 960 


Ile Thr Leu Pro Ser Glu Glu Cys Thr Thr Met Ile Asp Arg Gly Leu 
                965                 970                 975     


Gln Phe Glu Glu Arg Asn Phe Leu Leu Asn Gly Ser Ser Gln Lys Thr 
            980                 985                 990         


Phe His Ser Gln Leu Leu Arg Pro  Ser Asp Tyr Val Tyr  Glu Lys Glu 
        995                 1000                 1005             


Ile Lys  Asn Glu Pro Met Asn  Ser Ser Gly Pro Lys  Arg Lys Arg 
    1010                 1015                 1020             


Val Lys  Phe Thr Ser Tyr Thr  Thr Ile Leu Pro Glu  Asp Gly Gly 
    1025                 1030                 1035             


Pro Tyr  Thr Asn Ser Ile Leu  Phe Asp Ser Asp Asp  Asn Ile Lys 
    1040                 1045                 1050             


Trp Val  Cys Gln Asp Met Gly  Leu Gly Asp Ser Gln  Asp Phe Arg 
    1055                 1060                 1065             


Asp Tyr  Met Glu Ser Leu Gln  Asp Gln Met 
    1070                 1075             


<210>  5536
<211>  696
<212>  PRT
<213>  Homo sapiens

<400>  5536

Met Leu Leu Trp Ile Leu Leu Leu Glu Thr Ser Leu Cys Phe Ala Ala 
1               5                   10                  15      


Gly Asn Val Thr Gly Asp Val Cys Lys Glu Lys Ile Cys Ser Cys Asn 
            20                  25                  30          


Glu Ile Glu Gly Asp Leu His Val Asp Cys Glu Lys Lys Gly Phe Thr 
        35                  40                  45              


Ser Leu Gln Arg Phe Thr Ala Pro Thr Ser Gln Phe Tyr His Leu Phe 
    50                  55                  60                  


Leu His Gly Asn Ser Leu Thr Arg Leu Phe Pro Asn Glu Phe Ala Asn 
65                  70                  75                  80  


Phe Tyr Asn Ala Val Ser Leu His Met Glu Asn Asn Gly Leu His Glu 
                85                  90                  95      


Ile Val Pro Gly Ala Phe Leu Gly Leu Gln Leu Val Lys Arg Leu His 
            100                 105                 110         


Ile Asn Asn Asn Lys Ile Lys Ser Phe Arg Lys Gln Thr Phe Leu Gly 
        115                 120                 125             


Leu Asp Asp Leu Glu Tyr Leu Gln Ala Asp Phe Asn Leu Leu Arg Asp 
    130                 135                 140                 


Ile Asp Pro Gly Ala Phe Gln Asp Leu Asn Lys Leu Glu Val Leu Ile 
145                 150                 155                 160 


Leu Asn Asp Asn Leu Ile Ser Thr Leu Pro Ala Asn Val Phe Gln Tyr 
                165                 170                 175     


Val Pro Ile Thr His Leu Asp Leu Arg Gly Asn Arg Leu Lys Thr Leu 
            180                 185                 190         


Pro Tyr Glu Glu Val Leu Glu Gln Ile Pro Gly Ile Ala Glu Ile Leu 
        195                 200                 205             


Leu Glu Asp Asn Pro Trp Asp Cys Thr Cys Asp Leu Leu Ser Leu Lys 
    210                 215                 220                 


Glu Trp Leu Glu Asn Ile Pro Lys Asn Ala Leu Ile Gly Arg Val Val 
225                 230                 235                 240 


Cys Glu Ala Pro Thr Arg Leu Gln Gly Lys Asp Leu Asn Glu Thr Thr 
                245                 250                 255     


Glu Gln Asp Leu Cys Pro Leu Lys Asn Arg Val Asp Ser Ser Leu Pro 
            260                 265                 270         


Ala Pro Pro Ala Gln Glu Glu Thr Phe Ala Pro Gly Pro Leu Pro Thr 
        275                 280                 285             


Pro Phe Lys Thr Asn Gly Gln Glu Asp His Ala Thr Pro Gly Ser Ala 
    290                 295                 300                 


Pro Asn Gly Gly Thr Lys Ile Pro Gly Asn Trp Gln Ile Lys Ile Arg 
305                 310                 315                 320 


Pro Thr Ala Ala Ile Ala Thr Gly Ser Ser Arg Asn Lys Pro Leu Ala 
                325                 330                 335     


Asn Ser Leu Pro Cys Pro Gly Gly Cys Ser Cys Asp His Ile Pro Gly 
            340                 345                 350         


Ser Gly Leu Lys Met Asn Cys Asn Asn Arg Asn Val Ser Ser Leu Ala 
        355                 360                 365             


Asp Leu Lys Pro Lys Leu Ser Asn Val Gln Glu Leu Phe Leu Arg Asp 
    370                 375                 380                 


Asn Lys Ile His Ser Ile Arg Lys Ser His Phe Val Asp Tyr Lys Asn 
385                 390                 395                 400 


Leu Ile Leu Leu Asp Leu Gly Asn Asn Asn Ile Ala Thr Val Glu Asn 
                405                 410                 415     


Asn Thr Phe Lys Asn Leu Leu Asp Leu Arg Trp Leu Tyr Met Asp Ser 
            420                 425                 430         


Asn Tyr Leu Asp Thr Leu Ser Arg Glu Lys Phe Ala Gly Leu Gln Asn 
        435                 440                 445             


Leu Glu Tyr Leu Asn Val Glu Tyr Asn Ala Ile Gln Leu Ile Leu Pro 
    450                 455                 460                 


Gly Thr Phe Asn Ala Met Pro Lys Leu Arg Ile Leu Ile Leu Asn Asn 
465                 470                 475                 480 


Asn Leu Leu Arg Ser Leu Pro Val Asp Val Phe Ala Gly Val Ser Leu 
                485                 490                 495     


Ser Lys Leu Ser Leu His Asn Asn Tyr Phe Met Tyr Leu Pro Val Ala 
            500                 505                 510         


Gly Val Leu Asp Gln Leu Thr Ser Ile Ile Gln Ile Asp Leu His Gly 
        515                 520                 525             


Asn Pro Trp Glu Cys Ser Cys Thr Ile Val Pro Phe Lys Gln Trp Ala 
    530                 535                 540                 


Glu Arg Leu Gly Ser Glu Val Leu Met Ser Asp Leu Lys Cys Glu Thr 
545                 550                 555                 560 


Pro Val Asn Phe Phe Arg Lys Asp Phe Met Leu Leu Ser Asn Asp Glu 
                565                 570                 575     


Ile Cys Pro Gln Leu Tyr Ala Arg Ile Ser Pro Thr Leu Thr Ser His 
            580                 585                 590         


Ser Lys Asn Ser Thr Gly Leu Ala Glu Thr Gly Thr His Ser Asn Ser 
        595                 600                 605             


Tyr Leu Asp Thr Ser Arg Val Ser Ile Ser Val Leu Val Pro Gly Leu 
    610                 615                 620                 


Leu Leu Val Phe Val Thr Ser Ala Phe Thr Val Val Gly Met Leu Val 
625                 630                 635                 640 


Phe Ile Leu Arg Asn Arg Lys Arg Ser Lys Arg Arg Asp Ala Asn Ser 
                645                 650                 655     


Ser Ala Ser Glu Ile Asn Ser Leu Gln Thr Val Cys Asp Ser Ser Tyr 
            660                 665                 670         


Trp His Asn Gly Pro Tyr Asn Ala Asp Gly Ala His Arg Val Tyr Asp 
        675                 680                 685             


Cys Gly Ser His Ser Leu Ser Asp 
    690                 695     


<210>  5537
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  5537

Met Ile Ala Thr Gly Gly Val Ile Thr Gly Leu Ala Ala Leu Lys Arg 
1               5                   10                  15      


Gln Asp Ser Ala Arg Ser Gln Gln His Val Asn Leu Ser Pro Ser Pro 
            20                  25                  30          


Ala Thr Gln Glu Lys Lys Pro Ile Arg Arg Arg Pro Arg Ala Asp Val 
        35                  40                  45              


Val Val Val Arg Gly Lys Ile Arg Leu Tyr Ser Pro Ser Gly Phe Phe 
    50                  55                  60                  


Leu Ile Leu Gly Val Leu Ile Ser Ile Ile Gly Ile Ala Met Ala Val 
65                  70                  75                  80  


Leu Gly Tyr Trp Pro Gln Lys Glu His Phe Ile Asp Ala Glu Thr Thr 
                85                  90                  95      


Leu Ser Thr Asn Glu Thr Gln Val Ile Arg Asn Glu Gly Gly Val Val 
            100                 105                 110         


Val Arg Phe Phe Glu Gln His Leu His Ser Asp Lys Met Lys Met Leu 
        115                 120                 125             


Gly Pro Phe Thr Met Gly Ile Gly Ile Phe Ile Phe Ile Cys Ala Asn 
    130                 135                 140                 


Ala Ile Leu His Glu Asn Arg Asp Lys Glu Thr Lys Ile Ile His Met 
145                 150                 155                 160 


Arg Asp Ile Tyr Ser Thr Val Ile Asp Ile His Thr Leu Arg Ile Lys 
                165                 170                 175     


Glu Gln Arg Gln Met Asn Gly Met Tyr Thr Gly Leu Met Gly Glu Thr 
            180                 185                 190         


Glu Val Lys Gln Asn Gly Ser Ser Cys Ala Ser Arg Leu Ala Ala Asn 
        195                 200                 205             


Thr Ile Ala Ser Phe Ser Gly Phe Arg Ser Ser Phe Arg Met Asp Ser 
    210                 215                 220                 


Ser Val Glu Glu Asp Glu Leu Met Leu Asn Glu Gly Lys Ser Ser Gly 
225                 230                 235                 240 


His Leu Met Pro Pro Leu Leu Ser Asp Ser Ser Val Ser Val Phe Gly 
                245                 250                 255     


Leu Tyr Pro Pro Pro Ser Lys Thr Thr Asp Asp Lys Thr Ser Gly Ser 
            260                 265                 270         


Lys Lys Cys Glu Thr Lys Ser Ile Val Ser Ser Ser Ile Ser Ala Phe 
        275                 280                 285             


Thr Leu Pro Val Ile Lys Leu Asn Asn Cys Val Ile Asp Glu Pro Ser 
    290                 295                 300                 


Ile Asp Asn Ile Thr Glu Asp Ala Asp Asn Leu Lys Ser Arg Ser Arg 
305                 310                 315                 320 


Asn Leu Ser Met Asp Ser Leu Val Val Pro Leu Pro Asn Thr Ser Glu 
                325                 330                 335     


Ser Phe Gln Pro Val Ser Thr Val Leu Pro Arg Asn Asn Ser Ile Gly 
            340                 345                 350         


Glu Ser Leu Ser Ser Gln Tyr Lys Ser Ser Met Ala Leu Gly Pro Gly 
        355                 360                 365             


Ala Gly Gln Leu Leu Ser Pro Gly Ala Ala Arg Arg Gln Phe Gly Ser 
    370                 375                 380                 


Asn Thr Ser Leu His Leu Leu Ser Ser His Ser Lys Ser Leu Asp Leu 
385                 390                 395                 400 


Asp Arg Gly Pro Ser Thr Leu Thr Val Gln Ala Glu Gln Arg Lys His 
                405                 410                 415     


Pro Ser Trp Pro Arg Leu Asp Arg Asn Asn Ser Lys Gly Tyr Met Lys 
            420                 425                 430         


Leu Glu Asn Lys Glu Asp Pro Met Asp Arg Leu Leu Val Pro Gln Val 
        435                 440                 445             


Ala Ile Lys Lys Asp Phe Thr Asn Lys Glu Lys Leu Leu Met Ile Ser 
    450                 455                 460                 


Arg Ser His Asn Asn Leu Ser Phe Glu His Asp Glu Phe Leu Ser Asn 
465                 470                 475                 480 


Asn Leu Lys Arg Gly Thr Ser Glu Thr Arg Phe 
                485                 490     


<210>  5538
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  5538

Met Arg Arg Phe Val Tyr Cys Lys Val Val Leu Ala Thr Ser Leu Met 
1               5                   10                  15      


Trp Val Leu Val Asp Val Phe Leu Leu Leu Tyr Phe Ser Glu Cys Asn 
            20                  25                  30          


Lys Cys Asp Asp Lys Lys Glu Arg Ser Leu Leu Pro Ala Leu Arg Ala 
        35                  40                  45              


Val Ile Ser Arg Asn Gln Glu Gly Pro Gly Glu Met Gly Lys Ala Val 
    50                  55                  60                  


Leu Ile Pro Lys Asp Asp Gln Glu Lys Met Lys Glu Leu Phe Lys Ile 
65                  70                  75                  80  


Asn Gln Phe Asn Leu Met Ala Ser Asp Leu Ile Ala Leu Asn Arg Ser 
                85                  90                  95      


Leu Pro Asp Val Arg Leu Glu Gly Cys Lys Thr Lys Val Tyr Pro Asp 
            100                 105                 110         


Glu Leu Pro Asn Thr Ser Val Val Ile Val Phe His Asn Glu Ala Trp 
        115                 120                 125             


Ser Thr Leu Leu Arg Thr Val Tyr Ser Val Ile Asn Arg Ser Pro His 
    130                 135                 140                 


Tyr Leu Leu Ser Glu Val Ile Leu Val Asp Asp Ala Ser Glu Arg Asp 
145                 150                 155                 160 


Phe Leu Lys Leu Thr Leu Glu Asn Tyr Val Lys Asn Leu Glu Val Pro 
                165                 170                 175     


Val Lys Ile Ile Arg Met Glu Glu Arg Ser Gly Leu Ile Arg Ala Arg 
            180                 185                 190         


Leu Arg Gly Ala Ala Ala Ser Lys Gly Gln Val Ile Thr Phe Leu Asp 
        195                 200                 205             


Ala His Cys Glu Cys Thr Leu Gly Trp Leu Glu Pro Leu Leu Ala Arg 
    210                 215                 220                 


Ile Lys Glu Asp Arg Lys Thr Val Val Cys Pro Ile Ile Asp Val Ile 
225                 230                 235                 240 


Ser Asp Asp Thr Phe Glu Tyr Met Ala Gly Ser Asp Met Thr Tyr Gly 
                245                 250                 255     


Gly Phe Asn Trp Lys Leu Asn Phe Arg Trp Tyr Pro Val Pro Gln Arg 
            260                 265                 270         


Glu Met Asp Arg Arg Lys Gly Asp Arg Thr Leu Pro Val Arg Thr Pro 
        275                 280                 285             


Thr Met Ala Gly Gly Leu Phe Ser Ile Asp Arg Asn Tyr Phe Glu Glu 
    290                 295                 300                 


Ile Gly Thr Tyr Asp Ala Gly Met Asp Ile Trp Gly Gly Glu Asn Leu 
305                 310                 315                 320 


Glu Met Ser Phe Arg Ile Trp Gln Cys Gly Gly Ser Leu Glu Ile Val 
                325                 330                 335     


Thr Cys Ser His Val Gly His Val Phe Arg Lys Ala Thr Pro Tyr Thr 
            340                 345                 350         


Phe Pro Gly Gly Thr Gly His Val Ile Asn Lys Asn Asn Arg Arg Leu 
        355                 360                 365             


Ala Glu Val Trp Met Asp Glu Phe Lys Asp Phe Phe Tyr Ile Ile Ser 
    370                 375                 380                 


Pro Gly Val Val Lys Val Asp Tyr Gly Asp Val Ser Val Arg Lys Thr 
385                 390                 395                 400 


Leu Arg Glu Asn Leu Lys Cys Lys Pro Phe Ser Trp Tyr Leu Glu Asn 
                405                 410                 415     


Ile Tyr Pro Asp Ser Gln Ile Pro Arg Arg Tyr Tyr Ser Leu Gly Glu 
            420                 425                 430         


Ile Arg Asn Val Glu Thr Asn Gln Cys Leu Asp Asn Met Gly Arg Lys 
        435                 440                 445             


Glu Asn Glu Lys Val Gly Ile Phe Asn Cys His Gly Met Gly Gly Asn 
    450                 455                 460                 


Gln Val Phe Ser Tyr Thr Ala Asp Lys Glu Ile Arg Thr Asp Asp Leu 
465                 470                 475                 480 


Cys Leu Asp Val Ser Arg Leu Asn Gly Pro Val Ile Met Leu Lys Cys 
                485                 490                 495     


His His Met Arg Gly Asn Gln Leu Trp Glu Tyr Asp Ala Glu Arg Leu 
            500                 505                 510         


Thr Leu Arg His Val Asn Ser Asn Gln Cys Leu Asp Glu Pro Ser Glu 
        515                 520                 525             


Glu Asp Lys Met Val Pro Thr Met Gln Asp Cys Ser Gly Ser Arg Ser 
    530                 535                 540                 


Gln Gln Trp Leu Leu Arg Asn Met Thr Leu Gly Thr 
545                 550                 555     


<210>  5539
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  5539

Met Arg Lys Phe Ala Tyr Cys Lys Val Val Leu Ala Thr Ser Leu Ile 
1               5                   10                  15      


Trp Val Leu Leu Asp Met Phe Leu Leu Leu Tyr Phe Ser Glu Cys Asn 
            20                  25                  30          


Lys Cys Asp Glu Lys Lys Glu Arg Gly Leu Pro Ala Gly Asp Val Leu 
        35                  40                  45              


Glu Pro Val Gln Lys Pro His Glu Gly Pro Gly Glu Met Gly Lys Pro 
    50                  55                  60                  


Val Val Ile Pro Lys Glu Asp Gln Glu Lys Met Lys Glu Met Phe Lys 
65                  70                  75                  80  


Ile Asn Gln Phe Asn Leu Met Ala Ser Glu Met Ile Ala Leu Asn Arg 
                85                  90                  95      


Ser Leu Pro Asp Val Arg Leu Glu Gly Cys Lys Thr Lys Val Tyr Pro 
            100                 105                 110         


Asp Asn Leu Pro Thr Thr Ser Val Val Ile Val Phe His Asn Glu Ala 
        115                 120                 125             


Trp Ser Thr Leu Leu Arg Thr Val His Ser Val Ile Asn Arg Ser Pro 
    130                 135                 140                 


Arg His Met Ile Glu Glu Ile Val Leu Val Asp Asp Ala Ser Glu Arg 
145                 150                 155                 160 


Asp Phe Leu Lys Arg Pro Leu Glu Ser Tyr Val Lys Lys Leu Lys Val 
                165                 170                 175     


Pro Val His Val Ile Arg Met Glu Gln Arg Ser Gly Leu Ile Arg Ala 
            180                 185                 190         


Arg Leu Lys Gly Ala Ala Val Ser Lys Gly Gln Val Ile Thr Phe Leu 
        195                 200                 205             


Asp Ala His Cys Glu Cys Thr Val Gly Trp Leu Glu Pro Leu Leu Ala 
    210                 215                 220                 


Arg Ile Lys His Asp Arg Arg Thr Val Val Cys Pro Ile Ile Asp Val 
225                 230                 235                 240 


Ile Ser Asp Asp Thr Phe Glu Tyr Met Ala Gly Ser Asp Met Thr Tyr 
                245                 250                 255     


Gly Gly Phe Asn Trp Lys Leu Asn Phe Arg Trp Tyr Pro Val Pro Gln 
            260                 265                 270         


Arg Glu Met Asp Arg Arg Lys Gly Asp Arg Thr Leu Pro Val Arg Thr 
        275                 280                 285             


Pro Thr Met Ala Gly Gly Leu Phe Ser Ile Asp Arg Asp Tyr Phe Gln 
    290                 295                 300                 


Glu Ile Gly Thr Tyr Asp Ala Gly Met Asp Ile Trp Gly Gly Glu Asn 
305                 310                 315                 320 


Leu Glu Ile Ser Phe Arg Ile Trp Gln Cys Gly Gly Thr Leu Glu Ile 
                325                 330                 335     


Val Thr Cys Ser His Val Gly His Val Phe Arg Lys Ala Thr Pro Tyr 
            340                 345                 350         


Thr Phe Pro Gly Gly Thr Gly Gln Ile Ile Asn Lys Asn Asn Arg Arg 
        355                 360                 365             


Leu Ala Glu Val Trp Met Asp Glu Phe Lys Asn Phe Phe Tyr Ile Ile 
    370                 375                 380                 


Ser Pro Gly Val Thr Lys Val Asp Tyr Gly Asp Ile Ser Ser Arg Val 
385                 390                 395                 400 


Gly Leu Arg His Lys Leu Gln Cys Lys Pro Phe Ser Trp Tyr Leu Glu 
                405                 410                 415     


Asn Ile Tyr Pro Asp Ser Gln Ile Pro Arg His Tyr Phe Ser Leu Gly 
            420                 425                 430         


Glu Ile Arg Asn Val Glu Thr Asn Gln Cys Leu Asp Asn Met Ala Arg 
        435                 440                 445             


Lys Glu Asn Glu Lys Val Gly Ile Phe Asn Cys His Gly Met Gly Gly 
    450                 455                 460                 


Asn Gln Val Phe Ser Tyr Thr Ala Asn Lys Glu Ile Arg Thr Asp Asp 
465                 470                 475                 480 


Leu Cys Leu Asp Val Ser Lys Leu Asn Gly Pro Val Thr Met Leu Lys 
                485                 490                 495     


Cys His His Leu Lys Gly Asn Gln Leu Trp Glu Tyr Asp Pro Val Lys 
            500                 505                 510         


Leu Thr Leu Gln His Val Asn Ser Asn Gln Cys Leu Asp Lys Ala Thr 
        515                 520                 525             


Glu Glu Asp Ser Gln Val Pro Ser Ile Arg Asp Cys Asn Gly Ser Arg 
    530                 535                 540                 


Ser Gln Gln Trp Leu Leu Arg Asn Val Thr Leu Pro Glu Ile Phe 
545                 550                 555                 


<210>  5540
<211>  1168
<212>  PRT
<213>  Homo sapiens

<400>  5540

Met Gly Lys Val Gly Ala Gly Gly Gly Ser Gln Ala Arg Leu Ser Ala 
1               5                   10                  15      


Leu Leu Ala Gly Ala Gly Leu Leu Ile Leu Cys Ala Pro Gly Val Cys 
            20                  25                  30          


Gly Gly Gly Ser Cys Cys Pro Ser Pro His Pro Ser Ser Ala Pro Arg 
        35                  40                  45              


Ser Ala Ser Thr Pro Arg Gly Phe Ser His Gln Gly Arg Pro Gly Arg 
    50                  55                  60                  


Ala Pro Ala Thr Pro Leu Pro Leu Val Val Arg Pro Leu Phe Ser Val 
65                  70                  75                  80  


Ala Pro Gly Asp Arg Ala Leu Ser Leu Glu Arg Ala Arg Gly Thr Gly 
                85                  90                  95      


Ala Ser Met Ala Val Ala Ala Arg Ser Gly Arg Arg Arg Arg Ser Gly 
            100                 105                 110         


Ala Asp Gln Glu Lys Ala Glu Arg Gly Glu Gly Ala Ser Arg Ser Pro 
        115                 120                 125             


Arg Gly Val Leu Arg Asp Gly Gly Gln Gln Glu Pro Gly Thr Arg Glu 
    130                 135                 140                 


Arg Asp Pro Asp Lys Ala Thr Arg Phe Arg Met Glu Glu Leu Arg Leu 
145                 150                 155                 160 


Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala 
                165                 170                 175     


Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile Leu Thr 
            180                 185                 190         


Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp 
        195                 200                 205             


Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Val 
    210                 215                 220                 


Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys 
225                 230                 235                 240 


Arg Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser Leu Leu 
                245                 250                 255     


Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe 
            260                 265                 270         


Tyr Ile Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu 
        275                 280                 285             


Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe Gly Arg 
    290                 295                 300                 


Arg Trp Gln Leu Ile Gln Glu Gly Val Val Pro Asn Arg Phe Tyr Trp 
305                 310                 315                 320 


Ser Val Met Gly Ser Asn Lys Glu Pro Asp Leu Val His Leu Glu Ala 
                325                 330                 335     


Arg Thr Val Asp Gly His Ser His Tyr Leu Thr Cys Arg Met Gln Asn 
            340                 345                 350         


Cys Thr Glu Ala Asn Arg Asn Gln Pro Phe Pro Gly Tyr Ile Asp Pro 
        355                 360                 365             


Asp Ser Leu Ile Val Gln Asp His Tyr Val Phe Val Gln Leu Thr Ser 
    370                 375                 380                 


Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Asn Ala Phe Ala 
385                 390                 395                 400 


Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His Val Ile 
                405                 410                 415     


Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln 
            420                 425                 430         


Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe 
        435                 440                 445             


Thr Leu Ala Leu Glu Asn Val Gln Ser Ser Arg Gly Pro Glu Gly Asn 
    450                 455                 460                 


Ile Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu 
465                 470                 475                 480 


Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn 
                485                 490                 495     


Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Thr Asp Leu Arg 
            500                 505                 510         


Gly Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His Leu His 
        515                 520                 525             


Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala Ser Lys 
    530                 535                 540                 


Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Ser Glu 
545                 550                 555                 560 


Leu Ser Asp Thr Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn 
                565                 570                 575     


Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Val Leu Tyr Leu Asp 
            580                 585                 590         


Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro Ile Arg 
        595                 600                 605             


His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys Tyr Ser 
    610                 615                 620                 


Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu Pro Gly 
625                 630                 635                 640 


Glu Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His Arg Ser 
                645                 650                 655     


Glu Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp Arg Arg 
            660                 665                 670         


Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln Gly Glu 
        675                 680                 685             


Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu 
    690                 695                 700                 


Arg Lys Cys Met Gln Gly Lys Tyr Ala Gly Ala Met Glu Ser Glu Pro 
705                 710                 715                 720 


Cys Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg 
                725                 730                 735     


His Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser 
            740                 745                 750         


Leu Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Thr Gly 
        755                 760                 765             


Tyr Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln 
    770                 775                 780                 


Tyr Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu 
785                 790                 795                 800 


Arg Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn 
                805                 810                 815     


Val Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr Leu 
            820                 825                 830         


Ile Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn Leu 
        835                 840                 845             


Ser Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly Ile 
    850                 855                 860                 


Phe Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser Ala 
865                 870                 875                 880 


Val Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser 
                885                 890                 895     


Leu Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val 
            900                 905                 910         


Leu Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr Gly 
        915                 920                 925             


Asn Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe Arg 
    930                 935                 940                 


Phe Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly 
945                 950                 955                 960 


Asn Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu Phe 
                965                 970                 975     


Arg Ser Leu Arg Leu Ser Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro 
            980                 985                 990         


Asp Ile Pro Glu Trp Arg Arg Asp  Ile Gly Arg Val Ile  Lys Lys Ser 
        995                 1000                 1005             


Leu Val  Glu Ala Thr Gly Val  Pro Gly Gln His Ile  Leu Val Ala 
    1010                 1015                 1020             


Val Leu  Pro Gly Leu Pro Thr  Thr Ala Glu Leu Phe  Val Leu Pro 
    1025                 1030                 1035             


Tyr Gln  Asp Pro Ala Gly Glu  Asn Lys Arg Ser Thr  Asp Asp Leu 
    1040                 1045                 1050             


Glu Gln  Ile Ser Glu Leu Leu  Ile His Thr Leu Asn  Gln Asn Ser 
    1055                 1060                 1065             


Val His  Phe Glu Leu Lys Pro  Gly Val Arg Val Leu  Val His Ala 
    1070                 1075                 1080             


Ala His  Leu Thr Ala Ala Pro  Leu Val Asp Leu Thr  Pro Thr His 
    1085                 1090                 1095             


Ser Gly  Ser Ala Met Leu Met  Leu Leu Ser Val Val  Phe Val Gly 
    1100                 1105                 1110             


Leu Ala  Val Phe Val Ile Tyr  Lys Phe Lys Arg Arg  Val Ala Leu 
    1115                 1120                 1125             


Pro Ser  Pro Pro Ser Pro Ser  Thr Gln Pro Gly Asp  Ser Ser Leu 
    1130                 1135                 1140             


Arg Leu  Gln Arg Ala Arg His  Ala Thr Pro Pro Ser  Thr Pro Lys 
    1145                 1150                 1155             


Arg Gly  Ser Ala Gly Ala Gln  Tyr Ala Ile 
    1160                 1165             


<210>  5541
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  5541

Met Leu Trp Leu Phe Gln Ser Leu Leu Phe Val Phe Cys Phe Gly Pro 
1               5                   10                  15      


Gly Asn Val Val Ser Gln Ser Ser Leu Thr Pro Leu Met Val Asn Gly 
            20                  25                  30          


Ile Leu Gly Glu Ser Val Thr Leu Pro Leu Glu Phe Pro Ala Gly Glu 
        35                  40                  45              


Lys Val Asn Phe Ile Thr Trp Leu Phe Asn Glu Thr Ser Leu Ala Phe 
    50                  55                  60                  


Ile Val Pro His Glu Thr Lys Ser Pro Glu Ile His Val Thr Asn Pro 
65                  70                  75                  80  


Lys Gln Gly Lys Arg Leu Asn Phe Thr Gln Ser Tyr Ser Leu Gln Leu 
                85                  90                  95      


Ser Asn Leu Lys Met Glu Asp Thr Gly Ser Tyr Arg Ala Gln Ile Ser 
            100                 105                 110         


Thr Lys Thr Ser Ala Lys Leu Ser Ser Tyr Thr Leu Arg Ile Leu Arg 
        115                 120                 125             


Gln Leu Arg Asn Ile Gln Val Thr Asn His Ser Gln Leu Phe Gln Asn 
    130                 135                 140                 


Met Thr Cys Glu Leu His Leu Thr Cys Ser Val Glu Asp Ala Asp Asp 
145                 150                 155                 160 


Asn Val Ser Phe Arg Trp Glu Ala Leu Gly Asn Thr Leu Ser Ser Gln 
                165                 170                 175     


Pro Asn Leu Thr Val Ser Trp Asp Pro Arg Ile Ser Ser Glu Gln Asp 
            180                 185                 190         


Tyr Thr Cys Ile Ala Glu Asn Ala Val Ser Asn Leu Ser Phe Ser Val 
        195                 200                 205             


Ser Ala Gln Lys Leu Cys Glu Asp Val Lys Ile Gln Tyr Thr Asp Thr 
    210                 215                 220                 


Lys Met Ile Leu Phe Met Val Ser Gly Ile Cys Ile Val Phe Gly Phe 
225                 230                 235                 240 


Ile Ile Leu Leu Leu Leu Val Leu Arg Lys Arg Arg Asp Ser Leu Ser 
                245                 250                 255     


Leu Ser Thr Gln Arg Thr Gln Gly Pro Glu Ser Ala Arg Asn Leu Glu 
            260                 265                 270         


Tyr Val Ser Val Ser Pro Thr Asn Asn Thr Val Tyr Ala Ser Val Thr 
        275                 280                 285             


His Ser Asn Arg Glu Thr Glu Ile Trp Thr Pro Arg Glu Asn Asp Thr 
    290                 295                 300                 


Ile Thr Ile Tyr Ser Thr Ile Asn His Ser Lys Glu Ser Lys Pro Thr 
305                 310                 315                 320 


Phe Ser Arg Ala Thr Ala Leu Asp Asn Val Val 
                325                 330     


<210>  5542
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  5542

Met Gly Leu Gly Ala Arg Gly Ala Trp Ala Ala Leu Leu Leu Gly Thr 
1               5                   10                  15      


Leu Gln Val Leu Ala Leu Leu Gly Ala Ala His Glu Ser Ala Ala Met 
            20                  25                  30          


Ala Ala Ser Ala Asn Ile Glu Asn Ser Gly Leu Pro His Asn Ser Ser 
        35                  40                  45              


Ala Asn Ser Thr Glu Thr Leu Gln His Val Pro Ser Asp His Thr Asn 
    50                  55                  60                  


Glu Thr Ser Asn Ser Thr Val Lys Pro Pro Thr Ser Val Ala Ser Asp 
65                  70                  75                  80  


Ser Ser Asn Thr Thr Val Thr Thr Met Lys Pro Thr Ala Ala Ser Asn 
                85                  90                  95      


Thr Thr Thr Pro Gly Met Val Ser Thr Asn Met Thr Ser Thr Thr Leu 
            100                 105                 110         


Lys Ser Thr Pro Lys Thr Thr Ser Val Ser Gln Asn Thr Ser Gln Ile 
        115                 120                 125             


Ser Thr Ser Thr Met Thr Val Thr His Asn Ser Ser Val Thr Ser Ala 
    130                 135                 140                 


Ala Ser Ser Val Thr Ile Thr Thr Thr Met His Ser Glu Ala Lys Lys 
145                 150                 155                 160 


Gly Ser Lys Phe Asp Thr Gly Ser Phe Val Gly Gly Ile Val Leu Thr 
                165                 170                 175     


Leu Gly Val Leu Ser Ile Leu Tyr Ile Gly Cys Lys Met Tyr Tyr Ser 
            180                 185                 190         


Arg Arg Gly Ile Arg Tyr Arg Thr Ile Asp Glu His Asp Ala Ile Ile 
        195                 200                 205             


<210>  5543
<211>  791
<212>  PRT
<213>  Homo sapiens

<400>  5543

Met Ser Gln Pro Arg Pro Arg Tyr Val Val Asp Arg Ala Ala Tyr Ser 
1               5                   10                  15      


Leu Thr Leu Phe Asp Asp Glu Phe Glu Lys Lys Asp Arg Thr Tyr Pro 
            20                  25                  30          


Val Gly Glu Lys Leu Arg Asn Ala Phe Arg Cys Ser Ser Ala Lys Ile 
        35                  40                  45              


Lys Ala Val Val Phe Gly Leu Leu Pro Val Leu Ser Trp Leu Pro Lys 
    50                  55                  60                  


Tyr Lys Ile Lys Asp Tyr Ile Ile Pro Asp Leu Leu Gly Gly Leu Ser 
65                  70                  75                  80  


Gly Gly Ser Ile Gln Val Pro Gln Gly Met Ala Phe Ala Leu Leu Ala 
                85                  90                  95      


Asn Leu Pro Ala Val Asn Gly Leu Tyr Ser Ser Phe Phe Pro Leu Leu 
            100                 105                 110         


Thr Tyr Phe Phe Leu Gly Gly Val His Gln Met Val Pro Gly Thr Phe 
        115                 120                 125             


Ala Val Ile Ser Ile Leu Val Gly Asn Ile Cys Leu Gln Leu Ala Pro 
    130                 135                 140                 


Glu Ser Lys Phe Gln Val Phe Asn Asn Ala Thr Asn Glu Ser Tyr Val 
145                 150                 155                 160 


Asp Thr Ala Ala Met Glu Ala Glu Arg Leu His Val Ser Ala Thr Leu 
                165                 170                 175     


Ala Cys Leu Thr Ala Ile Ile Gln Met Gly Leu Gly Phe Met Gln Phe 
            180                 185                 190         


Gly Phe Val Ala Ile Tyr Leu Ser Glu Ser Phe Ile Arg Gly Phe Met 
        195                 200                 205             


Thr Ala Ala Gly Leu Gln Ile Leu Ile Ser Val Leu Lys Tyr Ile Phe 
    210                 215                 220                 


Gly Leu Thr Ile Pro Ser Tyr Thr Gly Pro Gly Ser Ile Val Phe Thr 
225                 230                 235                 240 


Phe Ile Asp Ile Cys Lys Asn Leu Pro His Thr Asn Ile Ala Ser Leu 
                245                 250                 255     


Ile Phe Ala Leu Ile Ser Gly Ala Phe Leu Val Leu Val Lys Glu Leu 
            260                 265                 270         


Asn Ala Arg Tyr Met His Lys Ile Arg Phe Pro Ile Pro Thr Glu Met 
        275                 280                 285             


Ile Val Val Val Val Ala Thr Ala Ile Ser Gly Gly Cys Lys Met Pro 
    290                 295                 300                 


Lys Lys Tyr His Met Gln Ile Val Gly Glu Ile Gln Arg Gly Phe Pro 
305                 310                 315                 320 


Thr Pro Val Ser Pro Val Val Ser Gln Trp Lys Asp Met Ile Gly Thr 
                325                 330                 335     


Ala Phe Ser Leu Ala Ile Val Ser Tyr Val Ile Asn Leu Ala Met Gly 
            340                 345                 350         


Arg Thr Leu Ala Asn Lys His Gly Tyr Asp Val Asp Ser Asn Gln Glu 
        355                 360                 365             


Met Ile Ala Leu Gly Cys Ser Asn Phe Phe Gly Ser Phe Phe Lys Ile 
    370                 375                 380                 


His Val Ile Cys Cys Ala Leu Ser Val Thr Leu Ala Val Asp Gly Ala 
385                 390                 395                 400 


Gly Gly Lys Ser Gln Val Ala Ser Leu Cys Val Ser Leu Val Val Met 
                405                 410                 415     


Ile Thr Met Leu Val Leu Gly Ile Tyr Leu Tyr Pro Leu Pro Lys Ser 
            420                 425                 430         


Val Leu Gly Ala Leu Ile Ala Val Asn Leu Lys Asn Ser Leu Lys Gln 
        435                 440                 445             


Leu Thr Asp Pro Tyr Tyr Leu Trp Arg Lys Ser Lys Leu Asp Cys Cys 
    450                 455                 460                 


Ile Trp Val Val Ser Phe Leu Ser Ser Phe Phe Leu Ser Leu Pro Tyr 
465                 470                 475                 480 


Gly Val Ala Val Gly Val Ala Phe Ser Val Leu Val Val Val Phe Gln 
                485                 490                 495     


Thr Gln Phe Arg Asn Gly Tyr Ala Leu Ala Gln Val Met Asp Thr Asp 
            500                 505                 510         


Ile Tyr Val Asn Pro Lys Thr Tyr Asn Arg Ala Gln Asp Ile Gln Gly 
        515                 520                 525             


Ile Lys Ile Ile Thr Tyr Cys Ser Pro Leu Tyr Phe Ala Asn Ser Glu 
    530                 535                 540                 


Ile Phe Arg Gln Lys Val Ile Ala Lys Thr Gly Met Asp Pro Gln Lys 
545                 550                 555                 560 


Val Leu Leu Ala Lys Gln Lys Tyr Leu Lys Lys Gln Glu Lys Arg Arg 
                565                 570                 575     


Met Arg Pro Thr Gln Gln Arg Arg Ser Leu Phe Met Lys Thr Lys Thr 
            580                 585                 590         


Val Ser Leu Gln Glu Leu Gln Gln Asp Phe Glu Asn Ala Pro Pro Thr 
        595                 600                 605             


Asp Pro Asn Asn Asn Gln Thr Pro Ala Asn Gly Thr Ser Val Ser Tyr 
    610                 615                 620                 


Ile Thr Phe Ser Pro Asp Ser Ser Ser Pro Ala Gln Ser Glu Pro Pro 
625                 630                 635                 640 


Ala Ser Ala Glu Ala Pro Gly Glu Pro Ser Asp Met Leu Ala Ser Val 
                645                 650                 655     


Pro Pro Phe Val Thr Phe His Thr Leu Ile Leu Asp Met Ser Gly Val 
            660                 665                 670         


Ser Phe Val Asp Leu Met Gly Ile Lys Ala Leu Ala Lys Leu Ser Ser 
        675                 680                 685             


Thr Tyr Gly Lys Ile Gly Val Lys Val Phe Leu Val Asn Ile His Ala 
    690                 695                 700                 


Gln Val Tyr Asn Asp Ile Ser His Gly Gly Val Phe Glu Asp Gly Ser 
705                 710                 715                 720 


Leu Glu Cys Lys His Val Phe Pro Ser Ile His Asp Ala Val Leu Phe 
                725                 730                 735     


Ala Gln Ala Asn Ala Arg Asp Val Thr Pro Gly His Asn Phe Gln Gly 
            740                 745                 750         


Ala Pro Gly Asp Ala Glu Leu Ser Leu Tyr Asp Ser Glu Glu Asp Ile 
        755                 760                 765             


Arg Ser Tyr Trp Asp Leu Glu Gln Glu Met Phe Gly Ser Met Phe His 
    770                 775                 780                 


Ala Glu Thr Leu Thr Ala Leu 
785                 790     


<210>  5544
<211>  429
<212>  PRT
<213>  Homo sapiens

<400>  5544

Met Leu Pro Arg Leu Leu Leu Leu Ile Cys Ala Pro Leu Cys Glu Pro 
1               5                   10                  15      


Ala Glu Leu Phe Leu Ile Ala Ser Pro Ser His Pro Thr Glu Gly Ser 
            20                  25                  30          


Pro Val Thr Leu Thr Cys Lys Met Pro Phe Leu Gln Ser Ser Asp Ala 
        35                  40                  45              


Gln Phe Gln Phe Cys Phe Phe Arg Asp Thr Arg Ala Leu Gly Pro Gly 
    50                  55                  60                  


Trp Ser Ser Ser Pro Lys Leu Gln Ile Ala Ala Met Trp Lys Glu Asp 
65                  70                  75                  80  


Thr Gly Ser Tyr Trp Cys Glu Ala Gln Thr Met Ala Ser Lys Val Leu 
                85                  90                  95      


Arg Ser Arg Arg Ser Gln Ile Asn Val His Arg Val Pro Val Ala Asp 
            100                 105                 110         


Val Ser Leu Glu Thr Gln Pro Pro Gly Gly Gln Val Met Glu Gly Asp 
        115                 120                 125             


Arg Leu Val Leu Ile Cys Ser Val Ala Met Gly Thr Gly Asp Ile Thr 
    130                 135                 140                 


Phe Leu Trp Tyr Lys Gly Ala Val Gly Leu Asn Leu Gln Ser Lys Thr 
145                 150                 155                 160 


Gln Arg Ser Leu Thr Ala Glu Tyr Glu Ile Pro Ser Val Arg Glu Ser 
                165                 170                 175     


Asp Ala Glu Gln Tyr Tyr Cys Val Ala Glu Asn Gly Tyr Gly Pro Ser 
            180                 185                 190         


Pro Ser Gly Leu Val Ser Ile Thr Val Arg Ile Pro Val Ser Arg Pro 
        195                 200                 205             


Ile Leu Met Leu Arg Ala Pro Arg Ala Gln Ala Ala Val Glu Asp Val 
    210                 215                 220                 


Leu Glu Leu His Cys Glu Ala Leu Arg Gly Ser Pro Pro Ile Leu Tyr 
225                 230                 235                 240 


Trp Phe Tyr His Glu Asp Ile Thr Leu Gly Ser Arg Ser Ala Pro Ser 
                245                 250                 255     


Gly Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Glu Glu His Ser Gly 
            260                 265                 270         


Asn Tyr Ser Cys Glu Ala Asn Asn Gly Leu Gly Ala Gln Arg Ser Glu 
        275                 280                 285             


Ala Val Thr Leu Asn Phe Thr Val Pro Thr Gly Ala Arg Ser Asn His 
    290                 295                 300                 


Leu Thr Ser Gly Val Ile Glu Gly Leu Leu Ser Thr Leu Gly Pro Ala 
305                 310                 315                 320 


Thr Val Ala Leu Leu Phe Cys Tyr Gly Leu Lys Arg Lys Ile Gly Arg 
                325                 330                 335     


Arg Ser Ala Arg Asp Pro Leu Arg Ser Leu Pro Ser Pro Leu Pro Gln 
            340                 345                 350         


Glu Phe Thr Tyr Leu Asn Ser Pro Thr Pro Gly Gln Leu Gln Pro Ile 
        355                 360                 365             


Tyr Glu Asn Val Asn Val Val Ser Gly Asp Glu Val Tyr Ser Leu Ala 
    370                 375                 380                 


Tyr Tyr Asn Gln Pro Glu Gln Glu Ser Val Ala Ala Glu Thr Leu Gly 
385                 390                 395                 400 


Thr His Met Glu Asp Lys Val Ser Leu Asp Ile Tyr Ser Arg Leu Arg 
                405                 410                 415     


Lys Ala Asn Ile Thr Asp Val Asp Tyr Glu Asp Ala Met 
            420                 425                 


<210>  5545
<211>  734
<212>  PRT
<213>  Homo sapiens

<400>  5545

Met Leu Leu Trp Leu Leu Leu Leu Ile Leu Thr Pro Gly Arg Glu Gln 
1               5                   10                  15      


Ser Gly Val Ala Pro Lys Ala Val Leu Leu Leu Asn Pro Pro Trp Ser 
            20                  25                  30          


Thr Ala Phe Lys Gly Glu Lys Val Ala Leu Ile Cys Ser Ser Ile Ser 
        35                  40                  45              


His Ser Leu Ala Gln Gly Asp Thr Tyr Trp Tyr His Asp Glu Lys Leu 
    50                  55                  60                  


Leu Lys Ile Lys His Asp Lys Ile Gln Ile Thr Glu Pro Gly Asn Tyr 
65                  70                  75                  80  


Gln Cys Lys Thr Arg Gly Ser Ser Leu Ser Asp Ala Val His Val Glu 
                85                  90                  95      


Phe Ser Pro Asp Trp Leu Ile Leu Gln Ala Leu His Pro Val Phe Glu 
            100                 105                 110         


Gly Asp Asn Val Ile Leu Arg Cys Gln Gly Lys Asp Asn Lys Asn Thr 
        115                 120                 125             


His Gln Lys Val Tyr Tyr Lys Asp Gly Lys Gln Leu Pro Asn Ser Tyr 
    130                 135                 140                 


Asn Leu Glu Lys Ile Thr Val Asn Ser Val Ser Arg Asp Asn Ser Lys 
145                 150                 155                 160 


Tyr His Cys Thr Ala Tyr Arg Lys Phe Tyr Ile Leu Asp Ile Glu Val 
                165                 170                 175     


Thr Ser Lys Pro Leu Asn Ile Gln Val Gln Glu Leu Phe Leu His Pro 
            180                 185                 190         


Val Leu Arg Ala Ser Ser Ser Thr Pro Ile Glu Gly Ser Pro Met Thr 
        195                 200                 205             


Leu Thr Cys Glu Thr Gln Leu Ser Pro Gln Arg Pro Asp Val Gln Leu 
    210                 215                 220                 


Gln Phe Ser Leu Phe Arg Asp Ser Gln Thr Leu Gly Leu Gly Trp Ser 
225                 230                 235                 240 


Arg Ser Pro Arg Leu Gln Ile Pro Ala Met Trp Thr Glu Asp Ser Gly 
                245                 250                 255     


Ser Tyr Trp Cys Glu Val Glu Thr Val Thr His Ser Ile Lys Lys Arg 
            260                 265                 270         


Ser Leu Arg Ser Gln Ile Arg Val Gln Arg Val Pro Val Ser Asn Val 
        275                 280                 285             


Asn Leu Glu Ile Arg Pro Thr Gly Gly Gln Leu Ile Glu Gly Glu Asn 
    290                 295                 300                 


Met Val Leu Ile Cys Ser Val Ala Gln Gly Ser Gly Thr Val Thr Phe 
305                 310                 315                 320 


Ser Trp His Lys Glu Gly Arg Val Arg Ser Leu Gly Arg Lys Thr Gln 
                325                 330                 335     


Arg Ser Leu Leu Ala Glu Leu His Val Leu Thr Val Lys Glu Ser Asp 
            340                 345                 350         


Ala Gly Arg Tyr Tyr Cys Ala Ala Asp Asn Val His Ser Pro Ile Leu 
        355                 360                 365             


Ser Thr Trp Ile Arg Val Thr Val Arg Ile Pro Val Ser His Pro Val 
    370                 375                 380                 


Leu Thr Phe Arg Ala Pro Arg Ala His Thr Val Val Gly Asp Leu Leu 
385                 390                 395                 400 


Glu Leu His Cys Glu Ser Leu Arg Gly Ser Pro Pro Ile Leu Tyr Arg 
                405                 410                 415     


Phe Tyr His Glu Asp Val Thr Leu Gly Asn Ser Ser Ala Pro Ser Gly 
            420                 425                 430         


Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Ala Glu His Ser Gly Asn 
        435                 440                 445             


Tyr Ser Cys Asp Ala Asp Asn Gly Leu Gly Ala Gln His Ser His Gly 
    450                 455                 460                 


Val Ser Leu Arg Val Thr Val Pro Val Ser Arg Pro Val Leu Thr Leu 
465                 470                 475                 480 


Arg Ala Pro Gly Ala Gln Ala Val Val Gly Asp Leu Leu Glu Leu His 
                485                 490                 495     


Cys Glu Ser Leu Arg Gly Ser Phe Pro Ile Leu Tyr Trp Phe Tyr His 
            500                 505                 510         


Glu Asp Asp Thr Leu Gly Asn Ile Ser Ala His Ser Gly Gly Gly Ala 
        515                 520                 525             


Ser Phe Asn Leu Ser Leu Thr Thr Glu His Ser Gly Asn Tyr Ser Cys 
    530                 535                 540                 


Glu Ala Asp Asn Gly Leu Gly Ala Gln His Ser Lys Val Val Thr Leu 
545                 550                 555                 560 


Asn Val Thr Gly Thr Ser Arg Asn Arg Thr Gly Leu Thr Ala Ala Gly 
                565                 570                 575     


Ile Thr Gly Leu Val Leu Ser Ile Leu Val Leu Ala Ala Ala Ala Ala 
            580                 585                 590         


Leu Leu His Tyr Ala Arg Ala Arg Arg Lys Pro Gly Gly Leu Ser Ala 
        595                 600                 605             


Thr Gly Thr Ser Ser His Ser Pro Ser Glu Cys Gln Glu Pro Ser Ser 
    610                 615                 620                 


Ser Arg Pro Ser Arg Ile Asp Pro Gln Glu Pro Thr His Ser Lys Pro 
625                 630                 635                 640 


Leu Ala Pro Met Glu Leu Glu Pro Met Tyr Ser Asn Val Asn Pro Gly 
                645                 650                 655     


Asp Ser Asn Pro Ile Tyr Ser Gln Ile Trp Ser Ile Gln His Thr Lys 
            660                 665                 670         


Glu Asn Ser Ala Asn Cys Pro Met Met His Gln Glu His Glu Glu Leu 
        675                 680                 685             


Thr Val Leu Tyr Ser Glu Leu Lys Lys Thr His Pro Asp Asp Ser Ala 
    690                 695                 700                 


Gly Glu Ala Ser Ser Arg Gly Arg Ala His Glu Glu Asp Asp Glu Glu 
705                 710                 715                 720 


Asn Tyr Glu Asn Val Pro Arg Val Leu Leu Ala Ser Asp His 
                725                 730                 


<210>  5546
<211>  675
<212>  PRT
<213>  Homo sapiens

<400>  5546

Met Glu Ser Gly Thr Ser Ser Pro Gln Pro Pro Gln Leu Asp Pro Leu 
1               5                   10                  15      


Asp Ala Phe Pro Gln Lys Gly Leu Glu Pro Gly Asp Ile Ala Val Leu 
            20                  25                  30          


Val Leu Tyr Phe Leu Phe Val Leu Ala Val Gly Leu Trp Ser Thr Val 
        35                  40                  45              


Lys Thr Lys Arg Asp Thr Val Lys Gly Tyr Phe Leu Ala Gly Gly Asp 
    50                  55                  60                  


Met Val Trp Trp Pro Val Gly Ala Ser Leu Phe Ala Ser Asn Val Gly 
65                  70                  75                  80  


Ser Gly His Phe Ile Gly Leu Ala Gly Ser Gly Ala Ala Thr Gly Ile 
                85                  90                  95      


Ser Val Ser Ala Tyr Glu Leu Asn Gly Leu Phe Ser Val Leu Met Leu 
            100                 105                 110         


Ala Trp Ile Phe Leu Pro Ile Tyr Ile Ala Gly Gln Val Thr Thr Met 
        115                 120                 125             


Pro Glu Tyr Leu Arg Lys Arg Phe Gly Gly Ile Arg Ile Pro Ile Ile 
    130                 135                 140                 


Leu Ala Val Leu Tyr Leu Phe Ile Tyr Ile Phe Thr Lys Ile Ser Val 
145                 150                 155                 160 


Asp Met Tyr Ala Gly Ala Ile Phe Ile Gln Gln Ser Leu His Leu Asp 
                165                 170                 175     


Leu Tyr Leu Ala Ile Val Gly Leu Leu Ala Ile Thr Ala Val Tyr Thr 
            180                 185                 190         


Val Ala Gly Gly Leu Ala Ala Val Ile Tyr Thr Asp Ala Leu Gln Thr 
        195                 200                 205             


Leu Ile Met Leu Ile Gly Ala Leu Thr Leu Met Gly Tyr Ser Phe Ala 
    210                 215                 220                 


Ala Val Gly Gly Met Glu Gly Leu Lys Glu Lys Tyr Phe Leu Ala Leu 
225                 230                 235                 240 


Ala Ser Asn Arg Ser Glu Asn Ser Ser Cys Gly Leu Pro Arg Glu Asp 
                245                 250                 255     


Ala Phe His Ile Phe Arg Asp Pro Leu Thr Ser Asp Leu Pro Trp Pro 
            260                 265                 270         


Gly Val Leu Phe Gly Met Ser Ile Pro Ser Leu Trp Tyr Trp Cys Thr 
        275                 280                 285             


Asp Gln Val Ile Val Gln Arg Thr Leu Ala Ala Lys Asn Leu Ser His 
    290                 295                 300                 


Ala Lys Gly Gly Ala Leu Met Ala Ala Tyr Leu Lys Val Leu Pro Leu 
305                 310                 315                 320 


Phe Ile Met Val Phe Pro Gly Met Val Ser Arg Ile Leu Phe Pro Asp 
                325                 330                 335     


Gln Val Ala Cys Ala Asp Pro Glu Ile Cys Gln Lys Ile Cys Ser Asn 
            340                 345                 350         


Pro Ser Gly Cys Ser Asp Ile Ala Tyr Pro Lys Leu Val Leu Glu Leu 
        355                 360                 365             


Leu Pro Thr Gly Leu Arg Gly Leu Met Met Ala Val Met Val Ala Ala 
    370                 375                 380                 


Leu Met Ser Ser Leu Thr Ser Ile Phe Asn Ser Ala Ser Thr Ile Phe 
385                 390                 395                 400 


Thr Met Asp Leu Trp Asn His Leu Arg Pro Arg Ala Ser Glu Lys Glu 
                405                 410                 415     


Leu Met Ile Val Gly Arg Val Phe Val Leu Leu Leu Val Leu Val Ser 
            420                 425                 430         


Ile Leu Trp Ile Pro Val Val Gln Ala Ser Gln Gly Gly Gln Leu Phe 
        435                 440                 445             


Ile Tyr Ile Gln Ser Ile Ser Ser Tyr Leu Gln Pro Pro Val Ala Val 
    450                 455                 460                 


Val Phe Ile Met Gly Cys Phe Trp Lys Arg Thr Asn Glu Lys Gly Ala 
465                 470                 475                 480 


Phe Trp Gly Leu Ile Ser Gly Leu Leu Leu Gly Leu Val Arg Leu Val 
                485                 490                 495     


Leu Asp Phe Ile Tyr Val Gln Pro Arg Cys Asp Gln Pro Asp Glu Arg 
            500                 505                 510         


Pro Val Leu Val Lys Ser Ile His Tyr Leu Tyr Phe Ser Met Ile Leu 
        515                 520                 525             


Ser Thr Val Thr Leu Ile Thr Val Ser Thr Val Ser Trp Phe Thr Glu 
    530                 535                 540                 


Pro Pro Ser Lys Glu Met Val Ser His Leu Thr Trp Phe Thr Arg His 
545                 550                 555                 560 


Asp Pro Val Val Gln Lys Glu Gln Ala Pro Pro Ala Ala Pro Leu Ser 
                565                 570                 575     


Leu Thr Leu Ser Gln Asn Gly Met Pro Glu Ala Ser Ser Ser Ser Ser 
            580                 585                 590         


Val Gln Phe Glu Met Val Gln Glu Asn Thr Ser Lys Thr His Ser Cys 
        595                 600                 605             


Asp Met Thr Pro Lys Gln Ser Lys Val Val Lys Ala Ile Leu Trp Leu 
    610                 615                 620                 


Cys Gly Ile Gln Glu Lys Gly Lys Glu Glu Leu Pro Ala Arg Ala Glu 
625                 630                 635                 640 


Ala Ile Ile Val Ser Leu Glu Glu Asn Pro Leu Val Lys Thr Leu Leu 
                645                 650                 655     


Asp Val Asn Leu Ile Phe Cys Val Ser Cys Ala Ile Phe Ile Trp Gly 
            660                 665                 670         


Tyr Phe Ala 
        675 


<210>  5547
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  5547

Met Arg Arg Gly Pro Arg Ser Leu Arg Gly Arg Asp Ala Pro Ala Pro 
1               5                   10                  15      


Thr Pro Cys Val Pro Ala Glu Cys Phe Asp Leu Leu Val Arg His Cys 
            20                  25                  30          


Val Ala Cys Gly Leu Leu Arg Thr Pro Arg Pro Lys Pro Ala Gly Ala 
        35                  40                  45              


Ser Ser Pro Ala Pro Arg Thr Ala Leu Gln Pro Gln Glu Ser Val Gly 
    50                  55                  60                  


Ala Gly Ala Gly Glu Ala Ala Leu Pro Leu Pro Gly Leu Leu Phe Gly 
65                  70                  75                  80  


Ala Pro Ala Leu Leu Gly Leu Ala Leu Val Leu Ala Leu Val Leu Val 
                85                  90                  95      


Gly Leu Val Ser Trp Arg Arg Arg Gln Arg Arg Leu Arg Gly Ala Ser 
            100                 105                 110         


Ser Ala Glu Ala Pro Asp Gly Asp Lys Asp Ala Pro Glu Pro Leu Asp 
        115                 120                 125             


Lys Val Ile Ile Leu Ser Pro Gly Ile Ser Asp Ala Thr Ala Pro Ala 
    130                 135                 140                 


Trp Pro Pro Pro Gly Glu Asp Pro Gly Thr Thr Pro Pro Gly His Ser 
145                 150                 155                 160 


Val Pro Val Pro Ala Thr Glu Leu Gly Ser Thr Glu Leu Val Thr Thr 
                165                 170                 175     


Lys Thr Ala Gly Pro Glu Gln Gln 
            180                 


<210>  5548
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  5548

Met Asn Leu Val Asp Leu Trp Leu Thr Arg Ser Leu Ser Met Cys Leu 
1               5                   10                  15      


Leu Leu Gln Ser Phe Val Leu Met Ile Leu Cys Phe His Ser Ala Ser 
            20                  25                  30          


Met Cys Pro Lys Gly Cys Leu Cys Ser Ser Ser Gly Gly Leu Asn Val 
        35                  40                  45              


Thr Cys Ser Asn Ala Asn Leu Lys Glu Ile Pro Arg Asp Leu Pro Pro 
    50                  55                  60                  


Glu Thr Val Leu Leu Tyr Leu Asp Ser Asn Gln Ile Thr Ser Ile Pro 
65                  70                  75                  80  


Asn Glu Ile Phe Lys Asp Leu His Gln Leu Arg Val Leu Asn Leu Ser 
                85                  90                  95      


Lys Asn Gly Ile Glu Phe Ile Asp Glu His Ala Phe Lys Gly Val Ala 
            100                 105                 110         


Glu Thr Leu Gln Thr Leu Asp Leu Ser Asp Asn Arg Ile Gln Ser Val 
        115                 120                 125             


His Lys Asn Ala Phe Asn Asn Leu Lys Ala Arg Ala Arg Ile Ala Asn 
    130                 135                 140                 


Asn Pro Trp His Cys Asp Cys Thr Leu Gln Gln Val Leu Arg Ser Met 
145                 150                 155                 160 


Ala Ser Asn His Glu Thr Ala His Asn Val Ile Cys Lys Thr Ser Val 
                165                 170                 175     


Leu Asp Glu His Ala Gly Arg Pro Phe Leu Asn Ala Ala Asn Asp Ala 
            180                 185                 190         


Asp Leu Cys Asn Leu Pro Lys Lys Thr Thr Asp Tyr Ala Met Leu Val 
        195                 200                 205             


Thr Met Phe Gly Trp Phe Thr Met Val Ile Ser Tyr Val Val Tyr Tyr 
    210                 215                 220                 


Val Arg Gln Asn Gln Glu Asp Ala Arg Arg His Leu Glu Tyr Leu Lys 
225                 230                 235                 240 


Ser Leu Pro Ser Arg Gln Lys Lys Ala Asp Glu Pro Asp Asp Ile Ser 
                245                 250                 255     


Thr Val Val 
            


<210>  5549
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  5549

Met Lys Cys Glu Pro Gly Trp Pro Arg Thr Pro Glu Trp Pro Pro Ser 
1               5                   10                  15      


Pro Arg Leu Ser Ala Val Gly Arg Asp Lys Glu Thr Trp Ala Pro Ser 
            20                  25                  30          


Ala Ala Arg Leu Gly Pro Arg Ala Pro Gln Leu Arg Gly Val Pro Gln 
        35                  40                  45              


Ser Leu Ala Arg Asp Ala Pro Gly Pro Gly Ser Leu Gly Arg Leu Pro 
    50                  55                  60                  


Arg Gln Trp Pro Gly Leu Cys Ser Thr Arg Leu Ser Gly Ala Leu Leu 
65                  70                  75                  80  


Ser Pro Ser Asp Arg Pro Pro Ser Ser Pro Phe Pro Pro Val Pro Gly 
                85                  90                  95      


Ser Pro Phe Ala Pro Ser Leu Arg Pro Pro Ala Trp Met Asp Ala Pro 
            100                 105                 110         


Arg Leu Pro Val Arg Pro Gly Val Leu Leu Pro Lys Leu Val Leu Leu 
        115                 120                 125             


Phe Val Tyr Ala Asp Asp Cys Leu Ala Gln Cys Gly Lys Asp Cys Lys 
    130                 135                 140                 


Ser Tyr Cys Cys Asp Gly Thr Thr Pro Tyr Cys Cys Ser Tyr Tyr Ala 
145                 150                 155                 160 


Tyr Ile Gly Asn Ile Leu Ser Gly Thr Ala Ile Ala Gly Ile Val Phe 
                165                 170                 175     


Gly Ile Val Phe Ile Met Gly Val Ile Ala Gly Ile Ala Ile Cys Ile 
            180                 185                 190         


Cys Met Cys Met Lys Asn His Arg Ala Thr Arg Val Gly Ile Leu Arg 
        195                 200                 205             


Thr Thr His Ile Asn Thr Val Ser Ser Tyr Pro Gly Pro Pro Pro Tyr 
    210                 215                 220                 


Gly His Asp His Glu Met Glu Tyr Cys Ala Asp Leu Pro Pro Pro Tyr 
225                 230                 235                 240 


Ser Pro Thr Pro Gln Gly Pro Ala Gln Arg Ser Pro Pro Pro Pro Tyr 
                245                 250                 255     


Pro Gly Asn Ala Arg Lys 
            260         


<210>  5550
<211>  577
<212>  PRT
<213>  Homo sapiens

<400>  5550

Met Gln Trp Leu Met Arg Phe Arg Thr Leu Trp Gly Ile His Lys Ser 
1               5                   10                  15      


Phe His Asn Ile His Pro Ala Pro Ser Gln Leu Arg Cys Arg Ser Leu 
            20                  25                  30          


Ser Glu Phe Gly Ala Pro Arg Trp Asn Asp Tyr Glu Val Pro Glu Glu 
        35                  40                  45              


Phe Asn Phe Ala Ser Tyr Val Leu Asp Tyr Trp Ala Gln Lys Glu Lys 
    50                  55                  60                  


Glu Gly Lys Arg Gly Pro Asn Pro Ala Phe Trp Trp Val Asn Gly Gln 
65                  70                  75                  80  


Gly Asp Glu Val Lys Trp Ser Phe Arg Glu Met Gly Asp Leu Thr Arg 
                85                  90                  95      


Arg Val Ala Asn Val Phe Thr Gln Thr Cys Gly Leu Gln Gln Gly Asp 
            100                 105                 110         


His Leu Ala Leu Met Leu Pro Arg Val Pro Glu Trp Trp Leu Val Ala 
        115                 120                 125             


Val Gly Cys Met Arg Thr Gly Ile Ile Phe Ile Pro Ala Thr Ile Leu 
    130                 135                 140                 


Leu Lys Ala Lys Asp Ile Leu Tyr Arg Leu Gln Leu Ser Lys Ala Lys 
145                 150                 155                 160 


Gly Ile Val Thr Ile Asp Ala Leu Ala Ser Glu Val Asp Ser Ile Ala 
                165                 170                 175     


Ser Gln Cys Pro Ser Leu Lys Thr Lys Leu Leu Val Ser Asp His Ser 
            180                 185                 190         


Arg Glu Gly Trp Leu Asp Phe Arg Ser Leu Val Lys Ser Ala Ser Pro 
        195                 200                 205             


Glu His Thr Cys Val Lys Ser Lys Thr Leu Asp Pro Met Val Ile Phe 
    210                 215                 220                 


Phe Thr Ser Gly Thr Thr Gly Phe Pro Lys Met Ala Lys His Ser His 
225                 230                 235                 240 


Gly Leu Ala Leu Gln Pro Ser Phe Pro Gly Ser Arg Lys Leu Arg Ser 
                245                 250                 255     


Leu Lys Thr Ser Asp Val Ser Trp Cys Leu Ser Asp Ser Gly Trp Ile 
            260                 265                 270         


Val Ala Thr Ile Trp Thr Leu Val Glu Pro Trp Thr Ala Gly Cys Thr 
        275                 280                 285             


Val Phe Ile His His Leu Pro Gln Phe Asp Thr Lys Val Ile Ile Gln 
    290                 295                 300                 


Thr Leu Leu Lys Tyr Pro Ile Asn His Phe Trp Gly Val Ser Ser Ile 
305                 310                 315                 320 


Tyr Arg Met Ile Leu Gln Gln Asp Phe Thr Ser Ile Arg Phe Pro Ala 
                325                 330                 335     


Leu Glu His Cys Tyr Thr Gly Gly Glu Val Val Leu Pro Lys Asp Gln 
            340                 345                 350         


Glu Glu Trp Lys Arg Arg Thr Gly Leu Leu Leu Tyr Glu Asn Tyr Gly 
        355                 360                 365             


Gln Ser Glu Thr Gly Leu Ile Cys Ala Thr Tyr Trp Gly Met Lys Ile 
    370                 375                 380                 


Lys Pro Gly Phe Met Gly Lys Ala Thr Pro Pro Tyr Asp Val Gln Val 
385                 390                 395                 400 


Ile Asp Asp Lys Gly Ser Ile Leu Pro Pro Asn Thr Glu Gly Asn Ile 
                405                 410                 415     


Gly Ile Arg Ile Lys Pro Val Arg Pro Val Ser Leu Phe Met Cys Tyr 
            420                 425                 430         


Glu Gly Asp Pro Glu Lys Thr Ala Lys Val Glu Cys Gly Asp Phe Tyr 
        435                 440                 445             


Asn Thr Gly Asp Arg Gly Lys Met Asp Glu Glu Gly Tyr Ile Cys Phe 
    450                 455                 460                 


Leu Gly Arg Ser Asp Asp Ile Ile Asn Ala Ser Gly Tyr Arg Ile Gly 
465                 470                 475                 480 


Pro Ala Glu Val Glu Ser Ala Leu Val Glu His Pro Ala Val Ala Glu 
                485                 490                 495     


Ser Ala Val Val Gly Ser Pro Asp Pro Ile Arg Gly Glu Val Val Lys 
            500                 505                 510         


Ala Phe Ile Val Leu Thr Pro Gln Phe Leu Ser His Asp Lys Asp Gln 
        515                 520                 525             


Leu Thr Lys Glu Leu Gln Gln His Val Lys Ser Val Thr Ala Pro Tyr 
    530                 535                 540                 


Lys Tyr Pro Arg Lys Val Glu Phe Val Ser Glu Leu Pro Lys Thr Ile 
545                 550                 555                 560 


Thr Gly Lys Ile Glu Arg Lys Glu Leu Arg Lys Lys Glu Thr Gly Gln 
                565                 570                 575     


Met 
    


<210>  5551
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  5551

Met Ser Leu Ala His Thr Ala Ala Glu Tyr Met Leu Ser Asp Ala Leu 
1               5                   10                  15      


Leu Pro Asp Arg Arg Gly Pro Arg Leu Lys Gly Leu Arg Leu Glu Leu 
            20                  25                  30          


Pro Leu Asp Arg Ile Val Lys Phe Val Ala Val Gly Ser Pro Leu Leu 
        35                  40                  45              


Leu Met Ser Leu Ala Phe Ala Gln Glu Phe Ser Ser Gly Ser Pro Ile 
    50                  55                  60                  


Ser Cys Phe Ser Pro Ser Asn Phe Ser Ile Arg Gln Ala Ala Tyr Val 
65                  70                  75                  80  


Asp Ser Ser Cys Trp Asp Ser Leu Leu His His Lys Gln Asp Gly Pro 
                85                  90                  95      


Gly Gln Asp Lys Met Lys Ser Leu Trp Pro His Lys Ala Leu Pro Tyr 
            100                 105                 110         


Ser Leu Leu Ala Leu Ala Leu Leu Met Tyr Leu Pro Val Leu Leu Trp 
        115                 120                 125             


Gln Tyr Ala Ala Val Pro Ala Leu Ser Ser Asp Leu Leu Phe Ile Ile 
    130                 135                 140                 


Ser Glu Leu Asp Lys Ser Tyr Asn Arg Ser Ile Arg Leu Val Gln His 
145                 150                 155                 160 


Met Leu Lys Ile Arg Gln Lys Ser Ser Asp Pro Tyr Val Phe Trp Asn 
                165                 170                 175     


Glu Leu Glu Lys Ala Arg Lys Glu Arg Tyr Phe Glu Phe Pro Leu Leu 
            180                 185                 190         


Glu Arg Tyr Leu Ala Cys Lys Gln Arg Ser His Ser Leu Val Ala Thr 
        195                 200                 205             


Tyr Leu Leu Arg Asn Ser Leu Leu Leu Ile Phe Thr Ser Ala Thr Tyr 
    210                 215                 220                 


Leu Tyr Leu Gly His Phe His Leu Asp Val Phe Phe Gln Glu Glu Phe 
225                 230                 235                 240 


Ser Cys Ser Ile Lys Thr Gly Leu Leu Ser Asp Glu Thr His Val Pro 
                245                 250                 255     


Asn Leu Ile Thr Cys Arg Leu Thr Ser Leu Ser Ile Phe Gln Ile Val 
            260                 265                 270         


Ser Leu Ser Ser Val Ala Ile Tyr Thr Ile Leu Val Pro Val Ile Ile 
        275                 280                 285             


Tyr Asn Leu Thr Arg Leu Cys Arg Trp Asp Lys Arg Leu Leu Ser Val 
    290                 295                 300                 


Tyr Glu Met Leu Pro Ala Phe Asp Leu Leu Ser Arg Lys Met Leu Gly 
305                 310                 315                 320 


Cys Pro Ile Asn Asp Leu Asn Val Ile Leu Leu Phe Leu Arg Ala Asn 
                325                 330                 335     


Ile Ser Glu Leu Ile Ser Phe Ser Trp Leu Ser Val Leu Cys Val Leu 
            340                 345                 350         


Lys Asp Thr Thr Thr Gln Lys His Asn Ile Asp Thr Val Val Asp Phe 
        355                 360                 365             


Met Thr Leu Leu Ala Gly Leu Glu Pro Ser Lys Pro Lys His Leu Thr 
    370                 375                 380                 


Asn Ser Ala Cys Asp Glu His Pro 
385                 390         


<210>  5552
<211>  970
<212>  PRT
<213>  Homo sapiens

<400>  5552

Met Ala Gln Leu Glu Arg Ser Ala Ile Ser Gly Phe Ser Ser Lys Ser 
1               5                   10                  15      


Arg Arg Asn Ser Phe Ala Tyr Asp Val Lys Arg Glu Val Tyr Asn Glu 
            20                  25                  30          


Glu Thr Phe Gln Gln Glu His Lys Arg Lys Ala Ser Ser Ser Gly Asn 
        35                  40                  45              


Met Asn Ile Asn Ile Thr Thr Phe Arg His His Val Gln Cys Arg Cys 
    50                  55                  60                  


Ser Trp His Arg Phe Leu Arg Cys Val Leu Thr Ile Phe Pro Phe Leu 
65                  70                  75                  80  


Glu Trp Met Cys Met Tyr Arg Leu Lys Asp Trp Leu Leu Gly Asp Leu 
                85                  90                  95      


Leu Ala Gly Ile Ser Val Gly Leu Val Gln Val Pro Gln Gly Leu Thr 
            100                 105                 110         


Leu Ser Leu Leu Ala Arg Gln Leu Ile Pro Pro Leu Asn Ile Ala Tyr 
        115                 120                 125             


Ala Ala Phe Cys Ser Ser Val Ile Tyr Val Ile Phe Gly Ser Cys His 
    130                 135                 140                 


Gln Met Ser Ile Gly Ser Phe Phe Leu Val Ser Ala Leu Leu Ile Asn 
145                 150                 155                 160 


Val Leu Lys Val Ser Pro Phe Asn Asn Gly Gln Leu Val Met Gly Ser 
                165                 170                 175     


Phe Val Lys Asn Glu Phe Ser Ala Pro Ser Tyr Leu Met Gly Tyr Asn 
            180                 185                 190         


Lys Ser Leu Ser Val Val Ala Thr Thr Thr Phe Leu Thr Gly Ile Ile 
        195                 200                 205             


Gln Leu Ile Met Gly Val Leu Gly Leu Gly Phe Ile Ala Thr Tyr Leu 
    210                 215                 220                 


Pro Glu Ser Ala Met Ser Ala Tyr Leu Ala Ala Val Ala Leu His Ile 
225                 230                 235                 240 


Met Leu Ser Gln Leu Thr Phe Ile Phe Gly Ile Met Ile Ser Phe His 
                245                 250                 255     


Ala Gly Pro Ile Ser Phe Phe Tyr Asp Ile Ile Asn Tyr Cys Val Ala 
            260                 265                 270         


Leu Pro Lys Ala Asn Ser Thr Ser Ile Leu Val Phe Leu Thr Val Val 
        275                 280                 285             


Val Ala Leu Arg Ile Asn Lys Cys Ile Arg Ile Ser Phe Asn Gln Tyr 
    290                 295                 300                 


Pro Ile Glu Phe Pro Met Glu Leu Phe Leu Ile Ile Gly Phe Thr Val 
305                 310                 315                 320 


Ile Ala Asn Lys Ile Ser Met Ala Thr Glu Thr Ser Gln Thr Leu Ile 
                325                 330                 335     


Asp Met Ile Pro Tyr Ser Phe Leu Leu Pro Val Thr Pro Asp Phe Ser 
            340                 345                 350         


Leu Leu Pro Lys Ile Ile Leu Gln Ala Phe Ser Leu Ser Leu Val Ser 
        355                 360                 365             


Ser Phe Leu Leu Ile Phe Leu Gly Lys Lys Ile Ala Ser Leu His Asn 
    370                 375                 380                 


Tyr Ser Val Asn Ser Asn Gln Asp Leu Ile Ala Ile Gly Leu Cys Asn 
385                 390                 395                 400 


Val Val Ser Ser Phe Phe Arg Ser Cys Val Phe Thr Gly Ala Ile Ala 
                405                 410                 415     


Arg Thr Ile Ile Gln Asp Lys Ser Gly Gly Arg Gln Gln Phe Ala Ser 
            420                 425                 430         


Leu Val Gly Ala Gly Val Met Leu Leu Leu Met Val Lys Met Gly His 
        435                 440                 445             


Phe Phe Tyr Thr Leu Pro Asn Ala Val Leu Ala Gly Ile Ile Leu Ser 
    450                 455                 460                 


Asn Val Ile Pro Tyr Leu Glu Thr Ile Ser Asn Leu Pro Ser Leu Trp 
465                 470                 475                 480 


Arg Gln Asp Gln Tyr Asp Cys Ala Leu Trp Met Met Thr Phe Ser Ser 
                485                 490                 495     


Ser Ile Phe Leu Gly Leu Asp Ile Gly Leu Ile Ile Ser Val Val Ser 
            500                 505                 510         


Ala Phe Phe Ile Thr Thr Val Arg Ser His Arg Ala Lys Ile Leu Leu 
        515                 520                 525             


Leu Gly Gln Ile Pro Asn Thr Asn Ile Tyr Arg Ser Ile Asn Asp Tyr 
    530                 535                 540                 


Arg Glu Ile Ile Thr Ile Pro Gly Val Lys Ile Phe Gln Cys Cys Ser 
545                 550                 555                 560 


Ser Ile Thr Phe Val Asn Val Tyr Tyr Leu Lys His Lys Leu Leu Lys 
                565                 570                 575     


Glu Val Asp Met Val Lys Val Pro Leu Lys Glu Glu Glu Ile Phe Ser 
            580                 585                 590         


Leu Phe Asn Ser Ser Asp Thr Asn Leu Gln Gly Gly Lys Ile Cys Arg 
        595                 600                 605             


Cys Phe Cys Asn Cys Asp Asp Leu Glu Pro Leu Pro Arg Ile Leu Tyr 
    610                 615                 620                 


Thr Glu Arg Phe Glu Asn Lys Leu Asp Pro Glu Ala Ser Ser Ile Asn 
625                 630                 635                 640 


Leu Ile His Cys Ser His Phe Glu Ser Met Asn Thr Ser Gln Thr Ala 
                645                 650                 655     


Ser Glu Asp Gln Val Pro Tyr Thr Val Ser Ser Val Ser Gln Lys Asn 
            660                 665                 670         


Gln Gly Gln Gln Tyr Glu Glu Val Glu Glu Val Trp Leu Pro Asn Asn 
        675                 680                 685             


Ser Ser Arg Asn Ser Ser Pro Gly Leu Pro Asp Val Ala Glu Ser Gln 
    690                 695                 700                 


Gly Arg Arg Ser Leu Ile Pro Tyr Ser Asp Ala Ser Leu Leu Pro Ser 
705                 710                 715                 720 


Val His Thr Ile Ile Leu Asp Phe Ser Met Val His Tyr Val Asp Ser 
                725                 730                 735     


Arg Gly Leu Val Val Leu Arg Gln Ile Cys Asn Ala Phe Gln Asn Ala 
            740                 745                 750         


Asn Ile Leu Ile Leu Ile Ala Gly Cys His Ser Ser Ile Val Arg Ala 
        755                 760                 765             


Phe Glu Arg Asn Asp Phe Phe Asp Ala Gly Ile Thr Lys Thr Gln Leu 
    770                 775                 780                 


Phe Leu Ser Val His Asp Ala Val Leu Phe Ala Leu Ser Arg Lys Val 
785                 790                 795                 800 


Ile Gly Ser Ser Glu Leu Ser Ile Asp Glu Ser Glu Thr Val Ile Arg 
                805                 810                 815     


Glu Thr Tyr Ser Glu Thr Asp Lys Asn Asp Asn Ser Arg Tyr Lys Met 
            820                 825                 830         


Ser Ser Ser Phe Leu Gly Ser Gln Lys Asn Val Ser Pro Gly Phe Ile 
        835                 840                 845             


Lys Ile Gln Gln Pro Val Glu Glu Glu Ser Glu Leu Asp Leu Glu Leu 
    850                 855                 860                 


Glu Ser Glu Gln Glu Ala Gly Leu Gly Leu Asp Leu Asp Leu Asp Arg 
865                 870                 875                 880 


Glu Leu Glu Pro Glu Met Glu Pro Lys Ala Glu Thr Glu Thr Lys Thr 
                885                 890                 895     


Gln Thr Glu Met Glu Pro Gln Pro Glu Thr Glu Pro Glu Met Glu Pro 
            900                 905                 910         


Asn Pro Lys Ser Arg Pro Arg Ala His Thr Phe Pro Gln Gln Arg Tyr 
        915                 920                 925             


Trp Pro Met Tyr His Pro Ser Met Ala Ser Thr Gln Ser Gln Thr Gln 
    930                 935                 940                 


Thr Arg Thr Trp Ser Val Glu Arg Arg Arg His Pro Met Asp Ser Tyr 
945                 950                 955                 960 


Ser Pro Glu Gly Asn Ser Asn Glu Asp Val 
                965                 970 


<210>  5553
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  5553

Met Val Trp Gly Lys Ile Cys Trp Phe Ser Gln Arg Ala Gly Trp Thr 
1               5                   10                  15      


Val Phe Ala Glu Ser Gln Ile Ser Leu Ser Cys Ser Leu Cys Leu His 
            20                  25                  30          


Ser Gly Asp Gln Glu Ala Gln Asn Pro Asn Leu Val Ser Gln Leu Cys 
        35                  40                  45              


Gly Val Phe Leu Gln Asn Glu Thr Asn Glu Thr Ile His Met Gln Met 
    50                  55                  60                  


Ser Met Ala Val Gly Gln Gln Ala Leu Pro Leu Asn Ile Ile Ala Pro 
65                  70                  75                  80  


Lys Ala Val Leu Val Ser Leu Cys Gly Val Leu Leu Asn Gly Thr Val 
                85                  90                  95      


Phe Trp Leu Leu Cys Cys Gly Ala Thr Asn Pro Tyr Met Val Tyr Ile 
            100                 105                 110         


Leu His Leu Val Ala Ala Asp Val Ile Tyr Leu Cys Cys Ser Ala Val 
        115                 120                 125             


Gly Phe Leu Gln Val Thr Leu Leu Thr Tyr His Gly Val Val Phe Phe 
    130                 135                 140                 


Ile Pro Asp Phe Leu Ala Ile Leu Ser Pro Phe Ser Phe Glu Val Cys 
145                 150                 155                 160 


Leu Cys Leu Leu Val Ala Ile Ser Thr Glu Arg Cys Val Cys Val Leu 
                165                 170                 175     


Phe Pro Ile Trp Tyr Arg Cys His Arg Pro Lys Tyr Thr Ser Asn Val 
            180                 185                 190         


Val Cys Thr Leu Ile Trp Gly Leu Pro Phe Cys Ile Asn Ile Val Lys 
        195                 200                 205             


Ser Leu Phe Leu Thr Tyr Trp Lys His Val Lys Ala Cys Val Ile Phe 
    210                 215                 220                 


Leu Lys Leu Ser Gly Leu Phe His Ala Ile Leu Ser Leu Val Met Cys 
225                 230                 235                 240 


Val Ser Ser Leu Thr Leu Leu Ile Arg Phe Leu Cys Cys Ser Gln Gln 
                245                 250                 255     


Gln Lys Ala Thr Arg Val Tyr Ala Val Val Gln Ile Ser Ala Pro Met 
            260                 265                 270         


Phe Leu Leu Trp Ala Leu Pro Leu Ser Val Ala Pro Leu Ile Thr Asp 
        275                 280                 285             


Phe Lys Met Phe Val Thr Thr Ser Tyr Leu Ile Ser Leu Phe Leu Ile 
    290                 295                 300                 


Ile Asn Ser Ser Ala Asn Pro Ile Ile Tyr Phe Phe Val Gly Ser Leu 
305                 310                 315                 320 


Arg Lys Lys Arg Leu Lys Glu Ser Leu Arg Val Ile Leu Gln Arg Ala 
                325                 330                 335     


Leu Ala Asp Lys Pro Glu Val Gly Arg Asn Lys Lys Ala Ala Gly Ile 
            340                 345                 350         


Asp Pro Met Glu Gln Pro His Ser Thr Gln His Val Glu Asn Leu Leu 
        355                 360                 365             


Pro Arg Glu His Arg Val Asp Val Glu Thr 
    370                 375             


<210>  5554
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  5554

Met Gln Ala Leu Gln Gln Gln Pro Val Phe Pro Asp Leu Leu Lys Ala 
1               5                   10                  15      


Ile Pro Val Ser Ile His Val Asn Val Ile Leu Phe Ser Ala Ile Leu 
            20                  25                  30          


Ile Val Leu Thr Met Val Gly Thr Ala Phe Phe Met Tyr Asn Ala Phe 
        35                  40                  45              


Gly Lys Pro Phe Glu Thr Leu His Gly Pro Leu Gly Leu Tyr Leu Leu 
    50                  55                  60                  


Ser Phe Ile Ser Gly Ser Cys Gly Cys Leu Val Met Ile Leu Phe Ala 
65                  70                  75                  80  


Ser Glu Val Lys Ile His His Leu Ser Glu Lys Ile Ala Asn Tyr Lys 
                85                  90                  95      


Glu Gly Thr Tyr Val Tyr Lys Thr Gln Ser Glu Lys Tyr Thr Thr Ser 
            100                 105                 110         


Phe Trp Leu Thr Lys Gly His Ser 
        115                 120 


<210>  5555
<211>  286
<212>  PRT
<213>  Homo sapiens

<400>  5555

Met Asp Pro Glu His Ala Lys Pro Glu Ser Ser Glu Ala Pro Ser Gly 
1               5                   10                  15      


Asn Leu Lys Gln Pro Glu Thr Ala Ala Ala Leu Ala Ser Ser Gly Ser 
            20                  25                  30          


Val Val Ser Ser Val Pro Lys Ala Gln Arg Asn Ile Ser Ala Lys Thr 
        35                  40                  45              


Ala Pro Arg Lys His Pro Ala Val Ser Ile Arg Ser Ala Gln Ser Ala 
    50                  55                  60                  


Ala Ala Ala Arg Pro Gln Gly Ser Glu Gly Thr Ala Pro Ser Arg Lys 
65                  70                  75                  80  


Ala Thr Thr Arg Pro Pro Pro Lys Pro Thr Leu Pro Pro Pro Thr Pro 
                85                  90                  95      


Ser Ala His Thr Glu Ser Lys Leu Leu Asn Glu Met Ala Ile Lys Glu 
            100                 105                 110         


Arg Val Glu Gly Arg Ala Lys Val Pro Tyr Lys Phe Arg Asp Ser Leu 
        115                 120                 125             


Lys Arg Phe Ser Phe Ser Pro Thr Gly Met Leu Lys Ile Leu Arg Leu 
    130                 135                 140                 


Ser Leu Ile Leu Gly Ala Leu Ala Cys Phe Ile Ile Thr Gln Ala Asn 
145                 150                 155                 160 


Glu Ser Phe Ile Thr Ile Thr Ser Leu Glu Ile Cys Ile Val Val Phe 
                165                 170                 175     


Phe Ile Leu Ile Tyr Val Leu Thr Leu His His Leu Leu Thr Tyr Leu 
            180                 185                 190         


His Trp Pro Leu Leu Asp Leu Thr Asn Ser Ile Ile Thr Ala Val Phe 
        195                 200                 205             


Leu Ser Val Val Ala Ile Leu Ala Met Gln Glu Lys Lys Arg Arg His 
    210                 215                 220                 


Leu Leu Tyr Val Gly Gly Ser Leu Cys Leu Thr Ala Val Ile Val Cys 
225                 230                 235                 240 


Cys Ile Asp Ala Phe Val Val Thr Thr Lys Met Arg Thr Asn Leu Lys 
                245                 250                 255     


Arg Phe Leu Gly Val Glu Val Glu Arg Lys Leu Ser Pro Ala Lys Asp 
            260                 265                 270         


Ala Tyr Pro Glu Thr Gly Pro Asp Ala Pro Gln Arg Pro Ala 
        275                 280                 285     


<210>  5556
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  5556

Met Ala Gly Trp Gln Ser Tyr Val Asp Asn Leu Met Cys Asp Gly Cys 
1               5                   10                  15      


Cys Gln Glu Ala Ala Ile Val Gly Tyr Cys Asp Ala Lys Tyr Val Trp 
            20                  25                  30          


Ala Ala Thr Ala Gly Gly Val Phe Gln Ser Ile Thr Pro Ile Glu Ile 
        35                  40                  45              


Asp Met Ile Val Gly Lys Asp Arg Glu Gly Phe Phe Thr Asn Gly Leu 
    50                  55                  60                  


Thr Leu Gly Ala Lys Lys Cys Ser Val Ile Arg Asp Ser Leu Tyr Val 
65                  70                  75                  80  


Asp Gly Asp Cys Thr Met Asp Ile Arg Thr Lys Ser Gln Gly Gly Glu 
                85                  90                  95      


Pro Thr Tyr Asn Val Ala Val Gly Arg Ala Gly Arg Val Leu Val Phe 
            100                 105                 110         


Val Met Gly Lys Glu Gly Val His Gly Gly Gly Leu Asn Lys Lys Ala 
        115                 120                 125             


Tyr Ser Met Ala Lys Tyr Leu Arg Asp Ser Gly Phe 
    130                 135                 140 


<210>  5557
<211>  368
<212>  PRT
<213>  Homo sapiens

<400>  5557

Met Ala Thr Ala Glu Arg Arg Ala Leu Gly Ile Gly Phe Gln Trp Leu 
1               5                   10                  15      


Ser Leu Ala Thr Leu Val Leu Ile Cys Ala Gly Gln Gly Gly Arg Arg 
            20                  25                  30          


Glu Asp Gly Gly Pro Ala Cys Tyr Gly Gly Phe Asp Leu Tyr Phe Ile 
        35                  40                  45              


Leu Asp Lys Ser Gly Ser Val Leu His His Trp Asn Glu Ile Tyr Tyr 
    50                  55                  60                  


Phe Val Glu Gln Leu Ala His Lys Phe Ile Ser Pro Gln Leu Arg Met 
65                  70                  75                  80  


Ser Phe Ile Val Phe Ser Thr Arg Gly Thr Thr Leu Met Lys Leu Thr 
                85                  90                  95      


Glu Asp Arg Glu Gln Ile Arg Gln Gly Leu Glu Glu Leu Gln Lys Val 
            100                 105                 110         


Leu Pro Gly Gly Asp Thr Tyr Met His Glu Gly Phe Glu Arg Ala Ser 
        115                 120                 125             


Glu Gln Ile Tyr Tyr Glu Asn Arg Gln Gly Tyr Arg Thr Ala Ser Val 
    130                 135                 140                 


Ile Ile Ala Leu Thr Asp Gly Glu Leu His Glu Asp Leu Phe Phe Tyr 
145                 150                 155                 160 


Ser Glu Arg Glu Ala Asn Arg Ser Arg Asp Leu Gly Ala Ile Val Tyr 
                165                 170                 175     


Cys Val Gly Val Lys Asp Phe Asn Glu Thr Gln Leu Ala Arg Ile Ala 
            180                 185                 190         


Asp Ser Lys Asp His Val Phe Pro Val Asn Asp Gly Phe Gln Ala Leu 
        195                 200                 205             


Gln Gly Ile Ile His Ser Ile Leu Lys Lys Ser Cys Ile Glu Ile Leu 
    210                 215                 220                 


Ala Ala Glu Pro Ser Thr Ile Cys Ala Gly Glu Ser Phe Gln Val Val 
225                 230                 235                 240 


Val Arg Gly Asn Gly Phe Arg His Ala Arg Asn Val Asp Arg Val Leu 
                245                 250                 255     


Cys Ser Phe Lys Ile Asn Asp Ser Val Thr Leu Asn Glu Lys Pro Phe 
            260                 265                 270         


Ser Val Glu Asp Thr Tyr Leu Leu Cys Pro Ala Pro Ile Leu Lys Glu 
        275                 280                 285             


Val Gly Met Lys Ala Ala Leu Gln Val Ser Met Asn Asp Gly Leu Ser 
    290                 295                 300                 


Phe Ile Ser Ser Ser Val Ile Ile Thr Thr Thr His Cys Ser Asp Gly 
305                 310                 315                 320 


Ser Ile Leu Ala Ile Ala Leu Leu Ile Leu Phe Leu Leu Leu Ala Leu 
                325                 330                 335     


Ala Leu Leu Trp Trp Phe Trp Pro Leu Cys Cys Thr Val Ile Ile Lys 
            340                 345                 350         


Glu Val Pro Pro Pro Pro Ala Glu Glu Ser Glu Glu Asn Lys Ile Lys 
        355                 360                 365             


<210>  5558
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  5558

Met Asn Glu Lys Trp Asp Thr Asn Ser Ser Glu Asn Trp His Pro Ile 
1               5                   10                  15      


Trp Asn Val Asn Asp Thr Lys His His Leu Tyr Ser Asp Ile Asn Ile 
            20                  25                  30          


Thr Tyr Val Asn Tyr Tyr Leu His Gln Pro Gln Val Ala Ala Ile Phe 
        35                  40                  45              


Ile Ile Ser Tyr Phe Leu Ile Phe Phe Leu Cys Met Met Gly Asn Thr 
    50                  55                  60                  


Val Val Cys Phe Ile Val Met Arg Asn Lys His Met His Thr Val Thr 
65                  70                  75                  80  


Asn Leu Phe Ile Leu Asn Leu Ala Ile Ser Asp Leu Leu Val Gly Ile 
                85                  90                  95      


Phe Cys Met Pro Ile Thr Leu Leu Asp Asn Ile Ile Ala Gly Trp Pro 
            100                 105                 110         


Phe Gly Asn Thr Met Cys Lys Ile Ser Gly Leu Val Gln Gly Ile Ser 
        115                 120                 125             


Val Ala Ala Ser Val Phe Thr Leu Val Ala Ile Ala Val Asp Arg Phe 
    130                 135                 140                 


Gln Cys Val Val Tyr Pro Phe Lys Pro Lys Leu Thr Ile Lys Thr Ala 
145                 150                 155                 160 


Phe Val Ile Ile Met Ile Ile Trp Val Leu Ala Ile Thr Ile Met Ser 
                165                 170                 175     


Pro Ser Ala Val Met Leu His Val Gln Glu Glu Lys Tyr Tyr Arg Val 
            180                 185                 190         


Arg Leu Asn Ser Gln Asn Lys Thr Ser Pro Val Tyr Trp Cys Arg Glu 
        195                 200                 205             


Asp Trp Pro Asn Gln Glu Met Arg Lys Ile Tyr Thr Thr Val Leu Phe 
    210                 215                 220                 


Ala Asn Ile Tyr Leu Ala Pro Leu Ser Leu Ile Val Ile Met Tyr Gly 
225                 230                 235                 240 


Arg Ile Gly Ile Ser Leu Phe Arg Ala Ala Val Pro His Thr Gly Arg 
                245                 250                 255     


Lys Asn Gln Glu Gln Trp His Val Val Ser Arg Lys Lys Gln Lys Ile 
            260                 265                 270         


Ile Lys Met Leu Leu Ile Val Ala Leu Leu Phe Ile Leu Ser Trp Leu 
        275                 280                 285             


Pro Leu Trp Thr Leu Met Met Leu Ser Asp Tyr Ala Asp Leu Ser Pro 
    290                 295                 300                 


Asn Glu Leu Gln Ile Ile Asn Ile Tyr Ile Tyr Pro Phe Ala His Trp 
305                 310                 315                 320 


Leu Ala Phe Gly Asn Ser Ser Val Asn Pro Ile Ile Tyr Gly Phe Phe 
                325                 330                 335     


Asn Glu Asn Phe Arg Arg Gly Phe Gln Glu Ala Phe Gln Leu Gln Leu 
            340                 345                 350         


Cys Gln Lys Arg Ala Lys Pro Met Glu Ala Tyr Ala Leu Lys Ala Lys 
        355                 360                 365             


Ser His Val Leu Ile Asn Thr Ser Asn Gln Leu Val Gln Glu Ser Thr 
    370                 375                 380                 


Phe Gln Asn Pro His Gly Glu Thr Leu Leu Tyr Arg Lys Ser Ala Glu 
385                 390                 395                 400 


Lys Pro Gln Gln Glu Leu Val Met Glu Glu Leu Lys Glu Thr Thr Asn 
                405                 410                 415     


Ser Ser Glu Ile 
            420 


<210>  5559
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  5559

Met Leu Phe Ser Leu Arg Glu Leu Val Gln Trp Leu Gly Phe Ala Thr 
1               5                   10                  15      


Phe Glu Ile Phe Val His Leu Leu Ala Leu Leu Val Phe Ser Val Leu 
            20                  25                  30          


Leu Ala Leu Arg Val Asp Gly Leu Val Pro Gly Leu Ser Trp Trp Asn 
        35                  40                  45              


Val Phe Val Pro Phe Phe Ala Ala Asp Gly Leu Ser Thr Tyr Phe Thr 
    50                  55                  60                  


Thr Ile Val Ser Val Arg Leu Phe Gln Asp Gly Glu Lys Arg Leu Ala 
65                  70                  75                  80  


Val Leu Arg Leu Phe Trp Val Leu Thr Val Leu Ser Leu Lys Phe Val 
                85                  90                  95      


Phe Glu Met Leu Leu Cys Gln Lys Leu Ala Glu Gln Thr Arg Glu Leu 
            100                 105                 110         


Trp Phe Gly Leu Ile Thr Ser Pro Leu Phe Ile Leu Leu Gln Leu Leu 
        115                 120                 125             


Met Ile Arg Ala Cys Arg Val Asn 
    130                 135     


<210>  5560
<211>  780
<212>  PRT
<213>  Homo sapiens

<400>  5560

Met Asp Gln Asn Ser Val Pro Glu Lys Ala Gln Asn Glu Ala Asp Thr 
1               5                   10                  15      


Asn Asn Ala Asp Arg Phe Phe Arg Ser His Ser Ser Pro Pro His His 
            20                  25                  30          


Arg Pro Gly His Ser Arg Ala Leu His His Tyr Glu Leu His His His 
        35                  40                  45              


Gly Val Pro His Gln Arg Gly Glu Ser His His Pro Pro Glu Phe Gln 
    50                  55                  60                  


Asp Phe His Asp Gln Ala Leu Ser Ser His Val His Gln Ser His His 
65                  70                  75                  80  


His Ser Glu Ala Arg Asn His Gly Arg Ala His Gly Pro Thr Gly Phe 
                85                  90                  95      


Gly Leu Ala Pro Ser Gln Gly Ala Val Pro Ser His Arg Ser Tyr Gly 
            100                 105                 110         


Glu Asp Tyr His Asp Glu Leu Gln Arg Asp Gly Arg Arg His His Asp 
        115                 120                 125             


Gly Ser Gln Tyr Gly Gly Phe His Gln Gln Ser Asp Ser His Tyr His 
    130                 135                 140                 


Arg Gly Ser His His Gly Arg Pro Gln Tyr Leu Gly Glu Asn Leu Ser 
145                 150                 155                 160 


His Tyr Ser Ser Gly Val Pro His His Gly Glu Ala Ser His His Gly 
                165                 170                 175     


Gly Ser Tyr Leu Pro His Gly Pro Asn Pro Tyr Ser Glu Ser Phe His 
            180                 185                 190         


His Ser Glu Ala Ser His Leu Ser Gly Leu Gln His Asp Glu Ser Gln 
        195                 200                 205             


His His Gln Val Pro His Arg Gly Trp Pro His His His Gln Val His 
    210                 215                 220                 


His His Gly Arg Ser Arg His His Glu Ala His Gln His Gly Lys Ser 
225                 230                 235                 240 


Pro His His Gly Glu Thr Ile Ser Pro His Ser Ser Val Gly Ser Tyr 
                245                 250                 255     


Gln Arg Gly Ile Ser Asp Tyr His Ser Glu Tyr His Gln Gly Asp His 
            260                 265                 270         


His Pro Ser Glu Tyr His His Gly Asp His Pro His His Thr Gln His 
        275                 280                 285             


His Tyr His Gln Thr His Arg His Arg Asp Tyr His Gln His Gln Asp 
    290                 295                 300                 


His His Gly Ala Tyr His Ser Ser Tyr Leu His Gly Asp Tyr Val Gln 
305                 310                 315                 320 


Ser Thr Ser Gln Leu Ser Ile Pro His Thr Ser Arg Ser Leu Ile His 
                325                 330                 335     


Asp Ala Pro Gly Pro Ala Ala Ser Arg Thr Gly Val Phe Pro Tyr His 
            340                 345                 350         


Val Ala His Pro Arg Gly Ser Ala His Ser Met Thr Arg Ser Ser Ser 
        355                 360                 365             


Thr Ile Arg Ser Arg Val Thr Gln Met Ser Lys Lys Val His Thr Gln 
    370                 375                 380                 


Asp Ile Ser Thr Lys His Ser Glu Asp Trp Gly Lys Glu Glu Gly Gln 
385                 390                 395                 400 


Phe Gln Lys Arg Lys Thr Gly Arg Leu Gln Arg Thr Arg Lys Lys Gly 
                405                 410                 415     


His Ser Thr Asn Leu Phe Gln Trp Leu Trp Glu Lys Leu Thr Phe Leu 
            420                 425                 430         


Ile Gln Gly Phe Arg Glu Met Ile Arg Asn Leu Thr Gln Ser Leu Ala 
        435                 440                 445             


Phe Glu Thr Phe Ile Phe Phe Val Val Cys Leu Asn Thr Val Met Leu 
    450                 455                 460                 


Val Ala Gln Thr Phe Ala Glu Val Glu Ile Arg Gly Glu Trp Tyr Phe 
465                 470                 475                 480 


Met Ala Leu Asp Ser Ile Phe Phe Cys Ile Tyr Val Val Glu Ala Leu 
                485                 490                 495     


Leu Lys Ile Ile Ala Leu Gly Leu Ser Tyr Phe Phe Asp Phe Trp Asn 
            500                 505                 510         


Asn Leu Asp Phe Phe Ile Met Ala Met Ala Val Leu Asp Phe Leu Leu 
        515                 520                 525             


Met Gln Thr His Ser Phe Ala Ile Tyr His Gln Ser Leu Phe Arg Ile 
    530                 535                 540                 


Leu Lys Val Phe Lys Ser Leu Arg Ala Leu Arg Ala Ile Arg Val Leu 
545                 550                 555                 560 


Arg Arg Leu Ser Phe Leu Thr Ser Val Gln Glu Val Thr Gly Thr Leu 
                565                 570                 575     


Gly Gln Ser Leu Pro Ser Ile Ala Ala Ile Leu Ile Leu Met Phe Thr 
            580                 585                 590         


Cys Leu Phe Leu Phe Ser Ala Val Leu Arg Ala Leu Phe Arg Lys Ser 
        595                 600                 605             


Asp Pro Lys Arg Phe Gln Asn Ile Phe Thr Thr Ile Phe Thr Leu Phe 
    610                 615                 620                 


Thr Leu Leu Thr Leu Asp Asp Trp Ser Leu Ile Tyr Met Asp Ser Arg 
625                 630                 635                 640 


Ala Gln Gly Ala Trp Tyr Ile Ile Pro Ile Leu Val Ile Tyr Ile Ile 
                645                 650                 655     


Ile Gln Tyr Phe Ile Phe Leu Asn Leu Val Ile Thr Val Leu Val Asp 
            660                 665                 670         


Ser Phe Gln Thr Ala Leu Phe Lys Gly Leu Glu Lys Ala Lys Gln Glu 
        675                 680                 685             


Arg Ala Ala Arg Ile Gln Glu Lys Leu Leu Glu Asp Ser Leu Thr Glu 
    690                 695                 700                 


Leu Arg Ala Ala Glu Pro Lys Glu Val Ala Ser Glu Gly Thr Met Leu 
705                 710                 715                 720 


Lys Arg Leu Ile Glu Lys Lys Phe Gly Thr Met Thr Glu Lys Gln Gln 
                725                 730                 735     


Glu Leu Leu Phe His Tyr Leu Gln Leu Val Ala Ser Val Glu Gln Glu 
            740                 745                 750         


Gln Gln Lys Phe Arg Ser Gln Ala Ala Val Ile Asp Glu Ile Val Asp 
        755                 760                 765             


Thr Thr Phe Glu Ala Gly Glu Glu Asp Phe Arg Asn 
    770                 775                 780 


<210>  5561
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  5561

Met Thr Ser Asn Phe Ser Gln Pro Val Val Gln Leu Cys Tyr Glu Asp 
1               5                   10                  15      


Val Asn Gly Ser Cys Ile Glu Thr Pro Tyr Ser Pro Gly Ser Arg Val 
            20                  25                  30          


Ile Leu Tyr Thr Ala Phe Ser Phe Gly Ser Leu Leu Ala Val Phe Gly 
        35                  40                  45              


Asn Leu Leu Val Met Thr Ser Val Leu His Phe Lys Gln Leu His Ser 
    50                  55                  60                  


Pro Thr Asn Phe Leu Ile Ala Ser Leu Ala Cys Ala Asp Phe Leu Val 
65                  70                  75                  80  


Gly Val Thr Val Met Leu Phe Ser Met Val Arg Thr Val Glu Ser Cys 
                85                  90                  95      


Trp Tyr Phe Gly Ala Lys Phe Cys Thr Leu His Ser Cys Cys Asp Val 
            100                 105                 110         


Ala Phe Cys Tyr Ser Ser Val Leu His Leu Cys Phe Ile Cys Ile Asp 
        115                 120                 125             


Arg Tyr Ile Val Val Thr Asp Pro Leu Val Tyr Ala Thr Lys Phe Thr 
    130                 135                 140                 


Val Ser Val Ser Gly Ile Cys Ile Ser Val Ser Trp Ile Leu Pro Leu 
145                 150                 155                 160 


Thr Tyr Ser Gly Ala Val Phe Tyr Thr Gly Val Asn Asp Asp Gly Leu 
                165                 170                 175     


Glu Glu Leu Val Ser Ala Leu Asn Cys Val Gly Gly Cys Gln Ile Ile 
            180                 185                 190         


Val Ser Gln Gly Trp Val Leu Ile Asp Phe Leu Leu Phe Phe Ile Pro 
        195                 200                 205             


Thr Leu Val Met Ile Ile Leu Tyr Ser Lys Ile Phe Leu Ile Ala Lys 
    210                 215                 220                 


Gln Gln Ala Ile Lys Ile Glu Thr Thr Ser Ser Lys Val Glu Ser Ser 
225                 230                 235                 240 


Ser Glu Ser Tyr Lys Ile Arg Val Ala Lys Arg Glu Arg Lys Ala Ala 
                245                 250                 255     


Lys Thr Leu Gly Val Thr Val Leu Ala Phe Val Ile Ser Trp Leu Pro 
            260                 265                 270         


Tyr Thr Val Asp Ile Leu Ile Asp Ala Phe Met Gly Phe Leu Thr Pro 
        275                 280                 285             


Ala Tyr Ile Tyr Glu Ile Cys Cys Trp Ser Ala Tyr Tyr Asn Ser Ala 
    290                 295                 300                 


Met Asn Pro Leu Ile Tyr Ala Leu Phe Tyr Pro Trp Phe Arg Lys Ala 
305                 310                 315                 320 


Ile Lys Leu Ile Leu Ser Gly Asp Val Leu Lys Ala Ser Ser Ser Thr 
                325                 330                 335     


Ile Ser Leu Phe Leu Glu 
            340         


<210>  5562
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  5562

Met Ser Arg Val Ala Gly Thr Arg Thr Asp Val Asn Glu Leu Leu Gln 
1               5                   10                  15      


Arg Trp Thr Pro Arg Cys Val Arg Trp His Thr Gly Gly Ala Arg Arg 
            20                  25                  30          


Val Ala Leu Asp Arg Pro Leu Val Thr Ala Cys Leu Pro Pro Ala Gly 
        35                  40                  45              


Asp Val Val Asp Val Tyr Gln Arg Glu Phe Leu Ala Leu Arg Asp Arg 
    50                  55                  60                  


Leu His Ala Ala Glu Gln Glu Ser Leu Lys Arg Ser Lys Glu Leu Asn 
65                  70                  75                  80  


Leu Val Leu Asp Glu Ile Lys Arg Ala Val Ser Glu Arg Gln Ala Leu 
                85                  90                  95      


Arg Asp Gly Asp Gly Asn Arg Thr Trp Gly Arg Leu Thr Glu Asp Pro 
            100                 105                 110         


Arg Leu Lys Pro Trp Asn Gly Ser His Arg His Val Leu His Leu Pro 
        115                 120                 125             


Thr Val Phe His His Leu Pro His Leu Leu Ala Lys Glu Ser Ser Leu 
    130                 135                 140                 


Gln Pro Ala Val Arg Val Gly Gln Gly Arg Thr Gly Val Ser Val Val 
145                 150                 155                 160 


Met Gly Ile Pro Ser Val Arg Arg Glu Val His Ser Tyr Leu Thr Asp 
                165                 170                 175     


Thr Leu His Ser Leu Ile Ser Glu Leu Ser Pro Gln Glu Lys Glu Asp 
            180                 185                 190         


Ser Val Ile Val Val Leu Ile Ala Glu Thr Asp Ser Gln Tyr Thr Ser 
        195                 200                 205             


Ala Val Thr Glu Asn Ile Lys Ala Leu Phe Pro Thr Glu Ile His Ser 
    210                 215                 220                 


Gly Leu Leu Glu Val Ile Ser Pro Ser Pro His Phe Tyr Pro Asp Phe 
225                 230                 235                 240 


Ser Arg Leu Arg Glu Ser Phe Gly Asp Pro Lys Glu Arg Val Arg Trp 
                245                 250                 255     


Arg Thr Lys Gln Asn Leu Asp Tyr Cys Phe Leu Met Met Tyr Ala Gln 
            260                 265                 270         


Ser Lys Gly Ile Tyr Tyr Val Gln Leu Glu Asp Asp Ile Val Ala Lys 
        275                 280                 285             


Pro Asn Tyr Leu Ser Thr Met Lys Asn Phe Ala Leu Gln Gln Pro Ser 
    290                 295                 300                 


Glu Asp Trp Met Ile Leu Glu Phe Ser Gln Leu Gly Phe Ile Gly Lys 
305                 310                 315                 320 


Met Phe Lys Ser Leu Asp Leu Ser Leu Ile Val Glu Phe Ile Leu Met 
                325                 330                 335     


Phe Tyr Arg Asp Lys Pro Ile Asp Trp Leu Leu Asp His Ile Leu Trp 
            340                 345                 350         


Val Lys Val Cys Asn Pro Glu Lys Asp Ala Lys His Cys Asp Arg Gln 
        355                 360                 365             


Lys Ala Asn Leu Arg Ile Arg Phe Lys Pro Ser Leu Phe Gln His Val 
    370                 375                 380                 


Gly Thr His Ser Ser Leu Ala Gly Lys Ile Gln Lys Leu Lys Asp Lys 
385                 390                 395                 400 


Asp Phe Gly Lys Gln Ala Leu Arg Lys Glu His Val Asn Pro Pro Ala 
                405                 410                 415     


Glu Val Ser Thr Ser Leu Lys Thr Tyr Gln His Phe Thr Leu Glu Lys 
            420                 425                 430         


Ala Tyr Leu Arg Glu Asp Phe Phe Trp Ala Phe Thr Pro Ala Ala Gly 
        435                 440                 445             


Asp Phe Ile Arg Phe Arg Phe Phe Gln Pro Leu Arg Leu Glu Arg Phe 
    450                 455                 460                 


Phe Phe Arg Ser Gly Asn Ile Glu His Pro Glu Asp Lys Leu Phe Asn 
465                 470                 475                 480 


Thr Ser Val Glu Val Leu Pro Phe Asp Asn Pro Gln Ser Asp Lys Glu 
                485                 490                 495     


Ala Leu Gln Glu Gly Arg Thr Ala Thr Leu Arg Tyr Pro Arg Ser Pro 
            500                 505                 510         


Asp Gly Tyr Leu Gln Ile Gly Ser Phe Tyr Lys Gly Val Ala Glu Gly 
        515                 520                 525             


Glu Val Asp Pro Ala Phe Gly Pro Leu Glu Ala Leu Arg Leu Ser Ile 
    530                 535                 540                 


Gln Thr Asp Ser Pro Val Trp Val Ile Leu Ser Glu Ile Phe Leu Lys 
545                 550                 555                 560 


Lys Ala Asp 
            


<210>  5563
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  5563

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105             


<210>  5564
<211>  528
<212>  PRT
<213>  Homo sapiens

<400>  5564

Met Ala Ala Tyr Gln Gln Glu Glu Gln Met Gln Leu Pro Arg Ala Asp 
1               5                   10                  15      


Ala Ile Arg Ser Arg Leu Ile Asp Thr Phe Ser Leu Ile Glu His Leu 
            20                  25                  30          


Gln Gly Leu Ser Gln Ala Val Pro Arg His Thr Ile Arg Glu Leu Leu 
        35                  40                  45              


Asp Pro Ser Arg Gln Lys Lys Leu Val Leu Gly Asp Gln His Gln Leu 
    50                  55                  60                  


Val Arg Phe Ser Ile Lys Pro Gln Arg Ile Glu Gln Ile Ser His Ala 
65                  70                  75                  80  


Gln Arg Leu Leu Ser Arg Leu His Val Arg Cys Ser Gln Arg Pro Pro 
                85                  90                  95      


Leu Ser Leu Trp Ala Gly Trp Val Leu Glu Cys Pro Leu Phe Lys Asn 
            100                 105                 110         


Phe Ile Ile Phe Leu Val Phe Leu Asn Thr Ile Ile Leu Met Val Glu 
        115                 120                 125             


Ile Glu Leu Leu Glu Ser Thr Asn Thr Lys Leu Trp Pro Leu Lys Leu 
    130                 135                 140                 


Thr Leu Glu Val Ala Ala Trp Phe Ile Leu Leu Ile Phe Ile Leu Glu 
145                 150                 155                 160 


Ile Leu Leu Lys Trp Leu Ser Asn Phe Ser Val Phe Trp Lys Ser Ala 
                165                 170                 175     


Trp Asn Val Phe Asp Phe Val Val Thr Met Leu Ser Leu Leu Pro Glu 
            180                 185                 190         


Val Val Val Leu Val Gly Val Thr Gly Gln Ser Val Trp Leu Gln Leu 
        195                 200                 205             


Leu Arg Ile Cys Arg Val Leu Arg Ser Leu Lys Leu Leu Ala Gln Phe 
    210                 215                 220                 


Arg Gln Ile Gln Ile Ile Ile Leu Val Leu Val Arg Ala Leu Lys Ser 
225                 230                 235                 240 


Met Thr Phe Leu Leu Met Leu Leu Leu Ile Phe Phe Tyr Ile Phe Ala 
                245                 250                 255     


Val Thr Gly Val Tyr Val Phe Ser Glu Tyr Thr Arg Ser Pro Arg Gln 
            260                 265                 270         


Asp Leu Glu Tyr His Val Phe Phe Ser Asp Leu Pro Asn Ser Leu Val 
        275                 280                 285             


Thr Val Phe Ile Leu Phe Thr Leu Asp His Trp Tyr Ala Leu Leu Gln 
    290                 295                 300                 


Asp Val Trp Lys Val Pro Glu Val Ser Arg Ile Phe Ser Ser Ile Tyr 
305                 310                 315                 320 


Phe Ile Leu Trp Leu Leu Leu Gly Ser Ile Ile Phe Arg Ser Ile Ile 
                325                 330                 335     


Val Ala Met Met Val Thr Asn Phe Gln Asn Ile Arg Lys Glu Leu Asn 
            340                 345                 350         


Glu Glu Met Ala Arg Arg Glu Val Gln Leu Lys Ala Asp Met Phe Lys 
        355                 360                 365             


Arg Gln Ile Ile Gln Arg Arg Lys Asn Met Ser His Glu Ala Leu Thr 
    370                 375                 380                 


Ser Ser His Ser Lys Ile Glu Asp Arg Gly Ala Ser Gln Gln Arg Glu 
385                 390                 395                 400 


Ser Leu Asp Leu Ser Glu Val Ser Glu Val Glu Ser Asn Tyr Gly Ala 
                405                 410                 415     


Thr Glu Glu Asp Leu Ile Thr Ser Ala Ser Lys Thr Glu Glu Thr Leu 
            420                 425                 430         


Ser Lys Lys Arg Glu Tyr Gln Ser Ser Ser Cys Val Ser Ser Thr Ser 
        435                 440                 445             


Ser Ser Tyr Ser Ser Ser Ser Glu Ser Arg Phe Ser Glu Ser Ile Gly 
    450                 455                 460                 


Arg Leu Asp Trp Glu Thr Leu Val His Glu Asn Leu Pro Gly Leu Met 
465                 470                 475                 480 


Glu Met Asp Gln Asp Asp Arg Val Trp Pro Arg Asp Ser Leu Phe Arg 
                485                 490                 495     


Tyr Phe Glu Leu Leu Glu Lys Leu Gln Tyr Asn Leu Glu Glu Arg Lys 
            500                 505                 510         


Lys Leu Gln Glu Phe Ala Val Gln Ala Leu Met Asn Leu Glu Asp Lys 
        515                 520                 525             


<210>  5565
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  5565

Met Thr Ser Thr Cys Thr Asn Ser Thr Arg Glu Ser Asn Ser Ser His 
1               5                   10                  15      


Thr Cys Met Pro Leu Ser Lys Met Pro Ile Ser Leu Ala His Gly Ile 
            20                  25                  30          


Ile Arg Ser Thr Val Leu Val Ile Phe Leu Ala Ala Ser Phe Val Gly 
        35                  40                  45              


Asn Ile Val Leu Ala Leu Val Leu Gln Arg Lys Pro Gln Leu Leu Gln 
    50                  55                  60                  


Val Thr Asn Arg Phe Ile Phe Asn Leu Leu Val Thr Asp Leu Leu Gln 
65                  70                  75                  80  


Ile Ser Leu Val Ala Pro Trp Val Val Ala Thr Ser Val Pro Leu Phe 
                85                  90                  95      


Trp Pro Leu Asn Ser His Phe Cys Thr Ala Leu Val Ser Leu Thr His 
            100                 105                 110         


Leu Phe Ala Phe Ala Ser Val Asn Thr Ile Val Val Val Ser Val Asp 
        115                 120                 125             


Arg Tyr Leu Ser Ile Ile His Pro Leu Ser Tyr Pro Ser Lys Met Thr 
    130                 135                 140                 


Gln Arg Arg Gly Tyr Leu Leu Leu Tyr Gly Thr Trp Ile Val Ala Ile 
145                 150                 155                 160 


Leu Gln Ser Thr Pro Pro Leu Tyr Gly Trp Gly Gln Ala Ala Phe Asp 
                165                 170                 175     


Glu Arg Asn Ala Leu Cys Ser Met Ile Trp Gly Ala Ser Pro Ser Tyr 
            180                 185                 190         


Thr Ile Leu Ser Val Val Ser Phe Ile Val Ile Pro Leu Ile Val Met 
        195                 200                 205             


Ile Ala Cys Tyr Ser Val Val Phe Cys Ala Ala Arg Arg Gln His Ala 
    210                 215                 220                 


Leu Leu Tyr Asn Val Lys Arg His Ser Leu Glu Val Arg Val Lys Asp 
225                 230                 235                 240 


Cys Val Glu Asn Glu Asp Glu Glu Gly Ala Glu Lys Lys Glu Glu Phe 
                245                 250                 255     


Gln Asp Glu Ser Glu Phe Arg Arg Gln His Glu Gly Glu Val Lys Ala 
            260                 265                 270         


Lys Glu Gly Arg Met Glu Ala Lys Asp Gly Ser Leu Lys Ala Lys Glu 
        275                 280                 285             


Gly Ser Thr Gly Thr Ser Glu Ser Ser Val Glu Ala Arg Gly Ser Glu 
    290                 295                 300                 


Glu Val Arg Glu Ser Ser Thr Val Ala Ser Asp Gly Ser Met Glu Gly 
305                 310                 315                 320 


Lys Glu Gly Ser Thr Lys Val Glu Glu Asn Ser Met Lys Ala Asp Lys 
                325                 330                 335     


Gly Arg Thr Glu Val Asn Gln Cys Ser Ile Asp Leu Gly Glu Asp Asp 
            340                 345                 350         


Met Glu Phe Gly Glu Asp Asp Ile Asn Phe Ser Glu Asp Asp Val Glu 
        355                 360                 365             


Ala Val Asn Ile Pro Glu Ser Leu Pro Pro Ser Arg Arg Asn Ser Asn 
    370                 375                 380                 


Ser Asn Pro Pro Leu Pro Arg Cys Tyr Gln Cys Lys Ala Ala Lys Val 
385                 390                 395                 400 


Ile Phe Ile Ile Ile Phe Ser Tyr Val Leu Ser Leu Gly Pro Tyr Cys 
                405                 410                 415     


Phe Leu Ala Val Leu Ala Val Trp Val Asp Val Glu Thr Gln Val Pro 
            420                 425                 430         


Gln Trp Val Ile Thr Ile Ile Ile Trp Leu Phe Phe Leu Gln Cys Cys 
        435                 440                 445             


Ile His Pro Tyr Val Tyr Gly Tyr Met His Lys Thr Ile Lys Lys Glu 
    450                 455                 460                 


Ile Gln Asp Met Leu Lys Lys Phe Phe Cys Lys Glu Lys Pro Pro Lys 
465                 470                 475                 480 


Glu Asp Ser His Pro Asp Leu Pro Gly Thr Glu Gly Gly Thr Glu Gly 
                485                 490                 495     


Lys Ile Val Pro Ser Tyr Asp Ser Ala Thr Phe Pro 
            500                 505             


<210>  5566
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  5566

Met Asp Pro Leu Phe Gln Gln Thr His Lys Gln Val His Glu Ile Gln 
1               5                   10                  15      


Ser Cys Met Gly Arg Leu Glu Thr Ala Asp Lys Gln Ser Val His Ile 
            20                  25                  30          


Val Glu Asn Glu Ile Gln Ala Ser Ile Asp Gln Ile Phe Ser Arg Leu 
        35                  40                  45              


Glu Arg Leu Glu Ile Leu Ser Ser Lys Glu Pro Pro Asn Lys Arg Gln 
    50                  55                  60                  


Asn Ala Arg Leu Arg Val Asp Gln Leu Lys Tyr Asp Val Gln His Leu 
65                  70                  75                  80  


Gln Thr Ala Leu Arg Asn Phe Gln His Arg Arg His Ala Arg Glu Gln 
                85                  90                  95      


Gln Glu Arg Gln Arg Glu Glu Leu Leu Ser Arg Thr Phe Thr Thr Asn 
            100                 105                 110         


Asp Ser Asp Thr Thr Ile Pro Met Asp Glu Ser Leu Gln Phe Asn Ser 
        115                 120                 125             


Ser Leu Gln Lys Val His Asn Gly Met Asp Asp Leu Ile Leu Asp Gly 
    130                 135                 140                 


His Asn Ile Leu Asp Gly Leu Arg Thr Gln Arg Leu Thr Leu Lys Gly 
145                 150                 155                 160 


Thr Gln Lys Lys Ile Leu Asp Ile Ala Asn Met Leu Gly Leu Ser Asn 
                165                 170                 175     


Thr Val Met Arg Leu Ile Glu Lys Arg Ala Phe Gln Asp Lys Tyr Phe 
            180                 185                 190         


Met Ile Gly Thr Gln Gly Ser Cys Gln Thr Ala His Phe Gly Gly Arg 
        195                 200                 205             


Ser Ala Gly Ser Ser 
    210             


<210>  5567
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  5567

Met Pro Lys Arg Arg Asp Ile Leu Ala Ile Val Leu Ile Val Leu Pro 
1               5                   10                  15      


Trp Thr Leu Leu Ile Thr Val Trp His Gln Ser Thr Leu Ala Pro Leu 
            20                  25                  30          


Leu Ala Val His Lys Asp Glu Gly Ser Asp Pro Arg Arg Glu Thr Pro 
        35                  40                  45              


Pro Gly Ala Asp Pro Arg Glu Tyr Cys Thr Ser Asp Arg Asp Ile Val 
    50                  55                  60                  


Glu Val Val Arg Thr Glu Tyr Val Tyr Thr Arg Pro Pro Pro Trp Ser 
65                  70                  75                  80  


Asp Thr Leu Pro Thr Ile His Val Val Thr Pro Thr Tyr Ser Arg Pro 
                85                  90                  95      


Val Gln Lys Ala Glu Leu Thr Arg Met Ala Asn Thr Leu Leu His Val 
            100                 105                 110         


Pro Asn Leu His Trp Leu Val Val Glu Asp Ala Pro Arg Arg Thr Pro 
        115                 120                 125             


Leu Thr Ala Arg Leu Leu Arg Asp Thr Gly Leu Asn Tyr Thr His Leu 
    130                 135                 140                 


His Val Glu Thr Pro Arg Asn Tyr Lys Leu Arg Gly Asp Ala Arg Asp 
145                 150                 155                 160 


Pro Arg Ile Pro Arg Gly Thr Met Gln Arg Asn Leu Ala Leu Arg Trp 
                165                 170                 175     


Leu Arg Glu Thr Phe Pro Arg Asn Ser Ser Gln Pro Gly Val Val Tyr 
            180                 185                 190         


Phe Ala Asp Asp Asp Asn Thr Tyr Ser Leu Glu Leu Phe Glu Glu Met 
        195                 200                 205             


Arg Ser Thr Arg Arg Val Ser Val Trp Pro Val Ala Phe Val Gly Gly 
    210                 215                 220                 


Leu Arg Tyr Glu Ala Pro Arg Val Asn Gly Ala Gly Lys Val Val Gly 
225                 230                 235                 240 


Trp Lys Thr Val Phe Asp Pro His Arg Pro Phe Ala Ile Asp Met Ala 
                245                 250                 255     


Gly Phe Ala Val Asn Leu Arg Leu Ile Leu Gln Arg Ser Gln Ala Tyr 
            260                 265                 270         


Phe Lys Leu Arg Gly Val Lys Gly Gly Tyr Gln Glu Ser Ser Leu Leu 
        275                 280                 285             


Arg Glu Leu Val Thr Leu Asn Asp Leu Glu Pro Lys Ala Ala Asn Cys 
    290                 295                 300                 


Thr Lys Ile Leu Val Trp His Thr Arg Thr Glu Lys Pro Val Leu Val 
305                 310                 315                 320 


Asn Glu Gly Lys Lys Gly Phe Thr Asp Pro Ser Val Glu Ile 
                325                 330                 


<210>  5568
<211>  492
<212>  PRT
<213>  Homo sapiens

<400>  5568

Met Val Lys Phe Pro Ala Leu Thr His Tyr Trp Pro Leu Ile Arg Phe 
1               5                   10                  15      


Leu Val Pro Leu Gly Ile Thr Asn Ile Ala Ile Asp Phe Gly Glu Gln 
            20                  25                  30          


Ala Leu Asn Arg Gly Ile Ala Ala Val Lys Glu Asp Ala Val Glu Met 
        35                  40                  45              


Leu Ala Ser Tyr Gly Leu Ala Tyr Ser Leu Met Lys Phe Phe Thr Gly 
    50                  55                  60                  


Pro Met Ser Asp Phe Lys Asn Val Gly Leu Val Phe Val Asn Ser Lys 
65                  70                  75                  80  


Arg Asp Arg Thr Lys Ala Val Leu Cys Met Val Val Ala Gly Ala Ile 
                85                  90                  95      


Ala Ala Val Phe His Thr Leu Ile Ala Tyr Ser Asp Leu Gly Tyr Tyr 
            100                 105                 110         


Ile Ile Asn Lys Leu His His Val Asp Glu Ser Val Gly Ser Lys Thr 
        115                 120                 125             


Arg Arg Ala Phe Leu Tyr Leu Ala Ala Phe Pro Phe Met Asp Ala Met 
    130                 135                 140                 


Ala Trp Thr His Ala Gly Ile Leu Leu Lys His Lys Tyr Ser Phe Leu 
145                 150                 155                 160 


Val Gly Cys Ala Ser Ile Ser Asp Val Ile Ala Gln Val Val Phe Val 
                165                 170                 175     


Ala Ile Leu Leu His Ser His Leu Glu Cys Arg Glu Pro Leu Leu Ile 
            180                 185                 190         


Pro Ile Leu Ser Leu Tyr Met Gly Ala Leu Val Arg Cys Thr Thr Leu 
        195                 200                 205             


Cys Leu Gly Tyr Tyr Lys Asn Ile His Asp Ile Ile Pro Asp Arg Ser 
    210                 215                 220                 


Gly Pro Glu Leu Gly Gly Asp Ala Thr Ile Arg Lys Met Leu Ser Phe 
225                 230                 235                 240 


Trp Trp Pro Leu Ala Leu Ile Leu Ala Thr Gln Arg Ile Ser Arg Pro 
                245                 250                 255     


Ile Val Asn Leu Phe Val Ser Arg Asp Leu Gly Gly Ser Ser Ala Ala 
            260                 265                 270         


Thr Glu Ala Val Ala Ile Leu Thr Ala Thr Tyr Pro Val Gly His Met 
        275                 280                 285             


Pro Tyr Gly Trp Leu Thr Glu Ile Arg Ala Val Tyr Pro Ala Phe Asp 
    290                 295                 300                 


Lys Asn Asn Pro Ser Asn Lys Leu Val Ser Thr Ser Asn Thr Val Thr 
305                 310                 315                 320 


Ala Ala His Ile Lys Lys Phe Thr Phe Val Cys Met Ala Leu Ser Leu 
                325                 330                 335     


Thr Leu Cys Phe Val Met Phe Trp Thr Pro Asn Val Ser Glu Lys Ile 
            340                 345                 350         


Leu Ile Asp Ile Ile Gly Val Asp Phe Ala Phe Ala Glu Leu Cys Val 
        355                 360                 365             


Val Pro Leu Arg Ile Phe Ser Phe Phe Pro Val Pro Val Thr Val Arg 
    370                 375                 380                 


Ala His Leu Thr Gly Trp Leu Met Thr Leu Lys Lys Thr Phe Val Leu 
385                 390                 395                 400 


Ala Pro Ser Ser Val Leu Arg Ile Ile Val Leu Ile Ala Ser Leu Val 
                405                 410                 415     


Val Leu Pro Tyr Leu Gly Val His Gly Ala Thr Leu Gly Val Gly Ser 
            420                 425                 430         


Leu Leu Ala Gly Phe Val Gly Glu Ser Thr Met Val Ala Ile Ala Ala 
        435                 440                 445             


Cys Tyr Val Tyr Arg Lys Gln Lys Lys Lys Met Glu Asn Glu Ser Ala 
    450                 455                 460                 


Thr Glu Gly Glu Asp Ser Ala Met Thr Asp Met Pro Pro Thr Glu Glu 
465                 470                 475                 480 


Val Thr Asp Ile Val Glu Met Arg Glu Glu Asn Glu 
                485                 490         


<210>  5569
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  5569

Met Ala Gly Ser His Pro Tyr Phe Asn Leu Pro Asp Ser Thr His Pro 
1               5                   10                  15      


Ser Pro Pro Ser Ala Pro Pro Ser Leu Arg Trp His Gln Arg Cys Gln 
            20                  25                  30          


Pro Ser Gly Ala Thr Asn Gly Leu Leu Val Ala Leu Leu Gly Gly Gly 
        35                  40                  45              


Leu Pro Ala Gly Phe Val Gly Pro Leu Ser Arg Met Ala Tyr Gln Gly 
    50                  55                  60                  


Ser Asn Leu Pro Ser Leu Glu Leu Leu Ile Cys Arg Cys Leu Phe His 
65                  70                  75                  80  


Leu Pro Ile Ala Leu Leu Leu Lys Leu Arg Gly Asp Pro Leu Leu Gly 
                85                  90                  95      


Pro Pro Asp Ile Arg Gly Trp Ala Cys Phe Cys Ala Leu Leu Asn Val 
            100                 105                 110         


Leu Ser Ile Gly Cys Ala Tyr Ser Ala Val Gln Val Val Pro Ala Gly 
        115                 120                 125             


Asn Ala Ala Thr Val Arg Lys Gly Ser Ser Thr Val Cys Ser Ala Val 
    130                 135                 140                 


Leu Thr Leu Cys Leu Glu Ser Gln Gly Leu Gly Gly Tyr Glu Trp Cys 
145                 150                 155                 160 


Gly Leu Leu Gly Ser Ile Leu Gly Leu Ile Ile Ile Leu Gly Pro Gly 
                165                 170                 175     


Leu Trp Thr Leu Gln Glu Gly Thr Thr Gly Val Tyr Thr Thr Leu Gly 
            180                 185                 190         


Tyr Val Gln Ala Phe Leu Gly Gly Leu Ala Leu Ser Leu Gly Leu Leu 
        195                 200                 205             


Val Tyr Arg Ser Leu His Phe Pro Ser Cys Leu Pro Thr Val Ala Phe 
    210                 215                 220                 


Leu Ser Gly Leu Val Gly Leu Leu Gly Cys Val Pro Gly Leu Phe Val 
225                 230                 235                 240 


Leu Gln Thr Pro Val Leu Pro Ser Asp Leu Leu Ser Trp Ser Cys Val 
                245                 250                 255     


Gly Ala Glu Gly Ile Leu Ala Leu Val Ser Phe Thr Cys Val Gly Tyr 
            260                 265                 270         


Ala Val Thr Lys Ala His Pro Ala Leu Val Cys Ala Val Leu His Ser 
        275                 280                 285             


Glu Val Val Val Ala Leu Ile Leu Gln Tyr Tyr Met Leu His Glu Thr 
    290                 295                 300                 


Val Ala Leu Ser Asp Ile Met Gly Ala Gly Val Val Leu Gly Ser Ile 
305                 310                 315                 320 


Ala Ile Ile Thr Ala Arg Asn Leu Ser Cys Glu Arg Thr Gly Lys Val 
                325                 330                 335     


Glu Glu 
        


<210>  5570
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  5570

Met Asp Pro Thr Thr Pro Ala Trp Gly Thr Glu Ser Thr Thr Val Asn 
1               5                   10                  15      


Gly Asn Asp Gln Ala Leu Leu Leu Leu Cys Gly Lys Glu Thr Leu Ile 
            20                  25                  30          


Pro Val Phe Leu Ile Leu Phe Ile Ala Leu Val Gly Leu Val Gly Asn 
        35                  40                  45              


Gly Phe Val Leu Trp Leu Leu Gly Phe Arg Met Arg Arg Asn Ala Phe 
    50                  55                  60                  


Ser Val Tyr Val Leu Ser Leu Ala Gly Ala Asp Phe Leu Phe Leu Cys 
65                  70                  75                  80  


Phe Gln Ile Ile Asn Cys Leu Val Tyr Leu Ser Asn Phe Phe Cys Ser 
                85                  90                  95      


Ile Ser Ile Asn Phe Pro Ser Phe Phe Thr Thr Val Met Thr Cys Ala 
            100                 105                 110         


Tyr Leu Ala Gly Leu Ser Met Leu Ser Thr Val Ser Thr Glu Arg Cys 
        115                 120                 125             


Leu Ser Val Leu Trp Pro Ile Trp Tyr Arg Cys Arg Arg Pro Arg His 
    130                 135                 140                 


Leu Ser Ala Val Val Cys Val Leu Leu Trp Ala Leu Ser Leu Leu Leu 
145                 150                 155                 160 


Ser Ile Leu Glu Gly Lys Phe Cys Gly Phe Leu Phe Ser Asp Gly Asp 
                165                 170                 175     


Ser Gly Trp Cys Gln Thr Phe Asp Phe Ile Thr Ala Ala Trp Leu Ile 
            180                 185                 190         


Phe Leu Phe Met Val Leu Cys Gly Ser Ser Leu Ala Leu Leu Val Arg 
        195                 200                 205             


Ile Leu Cys Gly Ser Arg Gly Leu Pro Leu Thr Arg Leu Tyr Leu Thr 
    210                 215                 220                 


Ile Leu Leu Thr Val Leu Val Phe Leu Leu Cys Gly Leu Pro Phe Gly 
225                 230                 235                 240 


Ile Gln Trp Phe Leu Ile Leu Trp Ile Trp Lys Asp Ser Asp Val Leu 
                245                 250                 255     


Phe Cys His Ile His Pro Val Ser Val Val Leu Ser Ser Leu Asn Ser 
            260                 265                 270         


Ser Ala Asn Pro Ile Ile Tyr Phe Phe Val Gly Ser Phe Arg Lys Gln 
        275                 280                 285             


Trp Arg Leu Gln Gln Pro Ile Leu Lys Leu Ala Leu Gln Arg Ala Leu 
    290                 295                 300                 


Gln Asp Ile Ala Glu Val Asp His Ser Glu Gly Cys Phe Arg Gln Gly 
305                 310                 315                 320 


Thr Pro Glu Met Ser Arg Ser Ser Leu Val 
                325                 330 


<210>  5571
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  5571

Met Asp Ser Thr Ile Pro Val Leu Gly Thr Glu Leu Thr Pro Ile Asn 
1               5                   10                  15      


Gly Arg Glu Glu Thr Pro Cys Tyr Lys Gln Thr Leu Ser Phe Thr Gly 
            20                  25                  30          


Leu Thr Cys Ile Val Ser Leu Val Ala Leu Thr Gly Asn Ala Val Val 
        35                  40                  45              


Leu Trp Leu Leu Gly Cys Arg Met Arg Arg Asn Ala Val Ser Ile Tyr 
    50                  55                  60                  


Ile Leu Asn Leu Val Ala Ala Asp Phe Leu Phe Leu Ser Gly His Ile 
65                  70                  75                  80  


Ile Cys Ser Pro Leu Arg Leu Ile Asn Ile Arg His Pro Ile Ser Lys 
                85                  90                  95      


Ile Leu Ser Pro Val Met Thr Phe Pro Tyr Phe Ile Gly Leu Ser Met 
            100                 105                 110         


Leu Ser Ala Ile Ser Thr Glu Arg Cys Leu Ser Ile Leu Trp Pro Ile 
        115                 120                 125             


Trp Tyr His Cys Arg Arg Pro Arg Tyr Leu Ser Ser Val Met Cys Val 
    130                 135                 140                 


Leu Leu Trp Ala Leu Ser Leu Leu Arg Ser Ile Leu Glu Trp Met Phe 
145                 150                 155                 160 


Cys Asp Phe Leu Phe Ser Gly Ala Asn Ser Val Trp Cys Glu Thr Ser 
                165                 170                 175     


Asp Phe Ile Thr Ile Ala Trp Leu Val Phe Leu Cys Val Val Leu Cys 
            180                 185                 190         


Gly Ser Ser Leu Val Leu Leu Val Arg Ile Leu Cys Gly Ser Arg Lys 
        195                 200                 205             


Met Pro Leu Thr Arg Leu Tyr Val Thr Ile Leu Leu Thr Val Leu Val 
    210                 215                 220                 


Phe Leu Leu Cys Gly Leu Pro Phe Gly Ile Gln Trp Ala Leu Phe Ser 
225                 230                 235                 240 


Arg Ile His Leu Asp Trp Lys Val Leu Phe Cys His Val His Leu Val 
                245                 250                 255     


Ser Ile Phe Leu Ser Ala Leu Asn Ser Ser Ala Asn Pro Ile Ile Tyr 
            260                 265                 270         


Phe Phe Val Gly Ser Phe Arg Gln Arg Gln Asn Arg Gln Asn Leu Lys 
        275                 280                 285             


Leu Val Leu Gln Arg Ala Leu Gln Asp Thr Pro Glu Val Asp Glu Gly 
    290                 295                 300                 


Gly Gly Trp Leu Pro Gln Glu Thr Leu Glu Leu Ser Gly Ser Arg Leu 
305                 310                 315                 320 


Glu Gln 
        


<210>  5572
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  5572

Met Asp Pro Thr Val Pro Val Phe Gly Thr Lys Leu Thr Pro Ile Asn 
1               5                   10                  15      


Gly Arg Glu Glu Thr Pro Cys Tyr Asn Gln Thr Leu Ser Phe Thr Val 
            20                  25                  30          


Leu Thr Cys Ile Ile Ser Leu Val Gly Leu Thr Gly Asn Ala Val Val 
        35                  40                  45              


Leu Trp Leu Leu Gly Tyr Arg Met Arg Arg Asn Ala Val Ser Ile Tyr 
    50                  55                  60                  


Ile Leu Asn Leu Ala Ala Ala Asp Phe Leu Phe Leu Ser Phe Gln Ile 
65                  70                  75                  80  


Ile Arg Leu Pro Leu Arg Leu Ile Asn Ile Ser His Leu Ile Arg Lys 
                85                  90                  95      


Ile Leu Val Ser Val Met Thr Phe Pro Tyr Phe Thr Gly Leu Ser Met 
            100                 105                 110         


Leu Ser Ala Ile Ser Thr Glu Arg Cys Leu Ser Val Leu Trp Pro Ile 
        115                 120                 125             


Trp Tyr Arg Cys Arg Arg Pro Thr His Leu Ser Ala Val Val Cys Val 
    130                 135                 140                 


Leu Leu Trp Gly Leu Ser Leu Leu Phe Ser Met Leu Glu Trp Arg Phe 
145                 150                 155                 160 


Cys Asp Phe Leu Phe Ser Gly Ala Asp Ser Ser Trp Cys Glu Thr Ser 
                165                 170                 175     


Asp Phe Ile Pro Val Ala Trp Leu Ile Phe Leu Cys Val Val Leu Cys 
            180                 185                 190         


Val Ser Ser Leu Val Leu Leu Val Arg Ile Leu Cys Gly Ser Arg Lys 
        195                 200                 205             


Met Pro Leu Thr Arg Leu Tyr Val Thr Ile Leu Leu Thr Val Leu Val 
    210                 215                 220                 


Phe Leu Leu Cys Gly Leu Pro Phe Gly Ile Leu Gly Ala Leu Ile Tyr 
225                 230                 235                 240 


Arg Met His Leu Asn Leu Glu Val Leu Tyr Cys His Val Tyr Leu Val 
                245                 250                 255     


Cys Met Ser Leu Ser Ser Leu Asn Ser Ser Ala Asn Pro Ile Ile Tyr 
            260                 265                 270         


Phe Phe Val Gly Ser Phe Arg Gln Arg Gln Asn Arg Gln Asn Leu Lys 
        275                 280                 285             


Leu Val Leu Gln Arg Ala Leu Gln Asp Lys Pro Glu Val Asp Lys Gly 
    290                 295                 300                 


Glu Gly Gln Leu Pro Glu Glu Ser Leu Glu Leu Ser Gly Ser Arg Leu 
305                 310                 315                 320 


Gly Pro 
        


<210>  5573
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  5573

Met Ser Pro Glu Asn Gln Ser Ser Val Ser Glu Phe Leu Leu Leu Gly 
1               5                   10                  15      


Leu Pro Ile Arg Pro Glu Gln Gln Ala Val Phe Phe Thr Leu Phe Leu 
            20                  25                  30          


Gly Met Tyr Leu Thr Thr Val Leu Gly Asn Leu Leu Ile Met Leu Leu 
        35                  40                  45              


Ile Gln Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 
    50                  55                  60                  


His Leu Ala Leu Thr Asp Ile Ser Phe Ser Ser Val Thr Val Pro Lys 
65                  70                  75                  80  


Met Leu Met Asp Met Arg Thr Lys Tyr Lys Ser Ile Leu Tyr Glu Glu 
                85                  90                  95      


Cys Ile Ser Gln Met Tyr Phe Phe Ile Phe Phe Thr Asp Leu Asp Ser 
            100                 105                 110         


Phe Leu Ile Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 
        115                 120                 125             


Pro Leu His Tyr Thr Val Ile Met Arg Glu Glu Leu Cys Val Phe Leu 
    130                 135                 140                 


Val Ala Val Ser Trp Ile Leu Ser Cys Ala Ser Ser Leu Ser His Thr 
145                 150                 155                 160 


Leu Leu Leu Thr Arg Leu Ser Phe Cys Ala Ala Asn Thr Ile Pro His 
                165                 170                 175     


Val Phe Cys Asp Leu Ala Ala Leu Leu Lys Leu Ser Cys Ser Asp Ile 
            180                 185                 190         


Phe Leu Asn Glu Leu Val Met Phe Thr Val Gly Val Val Val Ile Thr 
        195                 200                 205             


Leu Pro Phe Met Cys Ile Leu Val Ser Tyr Gly Tyr Ile Gly Ala Thr 
    210                 215                 220                 


Ile Leu Arg Val Pro Ser Thr Lys Gly Ile His Lys Ala Leu Ser Thr 
225                 230                 235                 240 


Cys Gly Ser His Leu Ser Val Val Ser Leu Tyr Tyr Gly Ser Ile Phe 
                245                 250                 255     


Gly Gln Tyr Leu Phe Pro Thr Val Ser Ser Ser Ile Asp Lys Asp Val 
            260                 265                 270         


Ile Val Ala Leu Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Arg Asp Met Lys Glu Ala Leu Gly Lys Leu 
    290                 295                 300                 


Phe Ser Arg Ala Thr Phe Phe Ser Trp 
305                 310             


<210>  5574
<211>  639
<212>  PRT
<213>  Homo sapiens

<400>  5574

Met Leu Leu Arg Lys Arg Tyr Arg His Arg Pro Cys Arg Leu Gln Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Met Leu Gly Cys Val Leu Met Met Val Ala Met 
            20                  25                  30          


Leu His Pro Pro His His Thr Leu His Gln Thr Val Thr Ala Gln Ala 
        35                  40                  45              


Ser Lys His Ser Pro Glu Ala Arg Tyr Arg Leu Asp Phe Gly Glu Ser 
    50                  55                  60                  


Gln Asp Trp Val Leu Glu Ala Glu Asp Glu Gly Glu Glu Tyr Ser Pro 
65                  70                  75                  80  


Leu Glu Gly Leu Pro Pro Phe Ile Ser Leu Arg Glu Asp Gln Leu Leu 
                85                  90                  95      


Val Ala Val Ala Leu Pro Gln Ala Arg Arg Asn Gln Ser Gln Gly Arg 
            100                 105                 110         


Arg Gly Gly Ser Tyr Arg Leu Ile Lys Gln Pro Arg Arg Gln Asp Lys 
        115                 120                 125             


Glu Ala Pro Lys Arg Asp Trp Gly Ala Asp Glu Asp Gly Glu Val Ser 
    130                 135                 140                 


Glu Glu Glu Glu Leu Thr Pro Phe Ser Leu Asp Pro Arg Gly Leu Gln 
145                 150                 155                 160 


Glu Ala Leu Ser Ala Arg Ile Pro Leu Gln Arg Ala Leu Pro Glu Val 
                165                 170                 175     


Arg His Pro Leu Cys Leu Gln Gln His Pro Gln Asp Ser Leu Pro Thr 
            180                 185                 190         


Ala Ser Val Ile Leu Cys Phe His Asp Glu Ala Trp Ser Thr Leu Leu 
        195                 200                 205             


Arg Thr Val His Ser Ile Leu Asp Thr Val Pro Arg Ala Phe Leu Lys 
    210                 215                 220                 


Glu Ile Ile Leu Val Asp Asp Leu Ser Gln Gln Gly Gln Leu Lys Ser 
225                 230                 235                 240 


Ala Leu Ser Glu Tyr Val Ala Arg Leu Glu Gly Val Lys Leu Leu Arg 
                245                 250                 255     


Ser Asn Lys Arg Leu Gly Ala Ile Arg Ala Arg Met Leu Gly Ala Thr 
            260                 265                 270         


Arg Ala Thr Gly Asp Val Leu Val Phe Met Asp Ala His Cys Glu Cys 
        275                 280                 285             


His Pro Gly Trp Leu Glu Pro Leu Leu Ser Arg Ile Ala Gly Asp Arg 
    290                 295                 300                 


Ser Arg Val Val Ser Pro Val Ile Asp Val Ile Asp Trp Lys Thr Phe 
305                 310                 315                 320 


Gln Tyr Tyr Pro Ser Lys Asp Leu Gln Arg Gly Val Leu Asp Trp Lys 
                325                 330                 335     


Leu Asp Phe His Trp Glu Pro Leu Pro Glu His Val Arg Lys Ala Leu 
            340                 345                 350         


Gln Ser Pro Ile Ser Pro Ile Arg Ser Pro Val Val Pro Gly Glu Val 
        355                 360                 365             


Val Ala Met Asp Arg His Tyr Phe Gln Asn Thr Gly Ala Tyr Asp Ser 
    370                 375                 380                 


Leu Met Ser Leu Arg Gly Gly Glu Asn Leu Glu Leu Ser Phe Lys Ala 
385                 390                 395                 400 


Trp Leu Cys Gly Gly Ser Val Glu Ile Leu Pro Cys Ser Arg Val Gly 
                405                 410                 415     


His Ile Tyr Gln Asn Gln Asp Ser His Ser Pro Leu Asp Gln Glu Ala 
            420                 425                 430         


Thr Leu Arg Asn Arg Val Arg Ile Ala Glu Thr Trp Leu Gly Ser Phe 
        435                 440                 445             


Lys Glu Thr Phe Tyr Lys His Ser Pro Glu Ala Phe Ser Leu Ser Lys 
    450                 455                 460                 


Ala Glu Lys Pro Asp Cys Met Glu Arg Leu Gln Leu Gln Arg Arg Leu 
465                 470                 475                 480 


Gly Cys Arg Thr Phe His Trp Phe Leu Ala Asn Val Tyr Pro Glu Leu 
                485                 490                 495     


Tyr Pro Ser Glu Pro Arg Pro Ser Phe Ser Gly Lys Leu His Asn Thr 
            500                 505                 510         


Gly Leu Gly Leu Cys Ala Asp Cys Gln Ala Glu Gly Asp Ile Leu Gly 
        515                 520                 525             


Cys Pro Met Val Leu Ala Pro Cys Ser Asp Ser Arg Gln Gln Gln Tyr 
    530                 535                 540                 


Leu Gln His Thr Ser Arg Lys Glu Ile His Phe Gly Ser Pro Gln His 
545                 550                 555                 560 


Leu Cys Phe Ala Val Arg Gln Glu Gln Val Ile Leu Gln Asn Cys Thr 
                565                 570                 575     


Glu Glu Gly Leu Ala Ile His Gln Gln His Trp Asp Phe Gln Glu Asn 
            580                 585                 590         


Gly Met Ile Val His Ile Leu Ser Gly Lys Cys Met Glu Ala Val Val 
        595                 600                 605             


Gln Glu Asn Asn Lys Asp Leu Tyr Leu Arg Pro Cys Asp Gly Lys Ala 
    610                 615                 620                 


Arg Gln Gln Trp Arg Phe Asp Gln Ile Asn Ala Val Asp Glu Arg 
625                 630                 635                 


<210>  5575
<211>  503
<212>  PRT
<213>  Homo sapiens

<400>  5575

Met Asp Leu Ile Pro Asn Phe Ala Met Glu Thr Trp Val Leu Val Ala 
1               5                   10                  15      


Thr Ser Leu Val Leu Leu Tyr Ile Tyr Gly Thr His Ser His Lys Leu 
            20                  25                  30          


Phe Lys Lys Leu Gly Ile Pro Gly Pro Thr Pro Leu Pro Phe Leu Gly 
        35                  40                  45              


Thr Ile Leu Phe Tyr Leu Arg Gly Leu Trp Asn Phe Asp Arg Glu Cys 
    50                  55                  60                  


Asn Glu Lys Tyr Gly Glu Met Trp Gly Leu Tyr Glu Gly Gln Gln Pro 
65                  70                  75                  80  


Met Leu Val Ile Met Asp Pro Asp Met Ile Lys Thr Val Leu Val Lys 
                85                  90                  95      


Glu Cys Tyr Ser Val Phe Thr Asn Gln Met Pro Leu Gly Pro Met Gly 
            100                 105                 110         


Phe Leu Lys Ser Ala Leu Ser Phe Ala Glu Asp Glu Glu Trp Lys Arg 
        115                 120                 125             


Ile Arg Thr Leu Leu Ser Pro Ala Phe Thr Ser Val Lys Phe Lys Glu 
    130                 135                 140                 


Met Val Pro Ile Ile Ser Gln Cys Gly Asp Met Leu Val Arg Ser Leu 
145                 150                 155                 160 


Arg Gln Glu Ala Glu Asn Ser Lys Ser Ile Asn Leu Lys Asp Phe Phe 
                165                 170                 175     


Gly Ala Tyr Thr Met Asp Val Ile Thr Gly Thr Leu Phe Gly Val Asn 
            180                 185                 190         


Leu Asp Ser Leu Asn Asn Pro Gln Asp Pro Phe Leu Lys Asn Met Lys 
        195                 200                 205             


Lys Leu Leu Lys Leu Asp Phe Leu Asp Pro Phe Leu Leu Leu Ile Ser 
    210                 215                 220                 


Leu Phe Pro Phe Leu Thr Pro Val Phe Glu Ala Leu Asn Ile Gly Leu 
225                 230                 235                 240 


Phe Pro Lys Asp Val Thr His Phe Leu Lys Asn Ser Ile Glu Arg Met 
                245                 250                 255     


Lys Glu Ser Arg Leu Lys Asp Lys Gln Lys His Arg Val Asp Phe Phe 
            260                 265                 270         


Gln Gln Met Ile Asp Ser Gln Asn Ser Lys Glu Thr Lys Ser His Lys 
        275                 280                 285             


Ala Leu Ser Asp Leu Glu Leu Val Ala Gln Ser Ile Ile Ile Ile Phe 
    290                 295                 300                 


Ala Ala Tyr Asp Thr Thr Ser Thr Thr Leu Pro Phe Ile Met Tyr Glu 
305                 310                 315                 320 


Leu Ala Thr His Pro Asp Val Gln Gln Lys Leu Gln Glu Glu Ile Asp 
                325                 330                 335     


Ala Val Leu Pro Asn Lys Ala Pro Val Thr Tyr Asp Ala Leu Val Gln 
            340                 345                 350         


Met Glu Tyr Leu Asp Met Val Val Asn Glu Thr Leu Arg Leu Phe Pro 
        355                 360                 365             


Val Val Ser Arg Val Thr Arg Val Cys Lys Lys Asp Ile Glu Ile Asn 
    370                 375                 380                 


Gly Val Phe Ile Pro Lys Gly Leu Ala Val Met Val Pro Ile Tyr Ala 
385                 390                 395                 400 


Leu His His Asp Pro Lys Tyr Trp Thr Glu Pro Glu Lys Phe Cys Pro 
                405                 410                 415     


Glu Arg Phe Ser Lys Lys Asn Lys Asp Ser Ile Asp Leu Tyr Arg Tyr 
            420                 425                 430         


Ile Pro Phe Gly Ala Gly Pro Arg Asn Cys Ile Gly Met Arg Phe Ala 
        435                 440                 445             


Leu Thr Asn Ile Lys Leu Ala Val Ile Arg Ala Leu Gln Asn Phe Ser 
    450                 455                 460                 


Phe Lys Pro Cys Lys Glu Thr Gln Ile Pro Leu Lys Leu Asp Asn Leu 
465                 470                 475                 480 


Pro Ile Leu Gln Pro Glu Lys Pro Ile Val Leu Lys Val His Leu Arg 
                485                 490                 495     


Asp Gly Ile Thr Ser Gly Pro 
            500             


<210>  5576
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  5576

Met Asp Leu Ile Pro Asn Phe Ala Met Glu Thr Trp Val Leu Val Ala 
1               5                   10                  15      


Thr Ser Leu Val Leu Leu Tyr Ile Tyr Gly Thr His Ser His Lys Leu 
            20                  25                  30          


Phe Lys Lys Leu Gly Ile Pro Gly Pro Thr Pro Leu Pro Phe Leu Gly 
        35                  40                  45              


Thr Ile Leu Phe Tyr Leu Arg Gly Leu Trp Asn Phe Asp Arg Glu Cys 
    50                  55                  60                  


Asn Glu Lys Tyr Gly Glu Met Trp Gly Leu Tyr Glu Gly Gln Gln Pro 
65                  70                  75                  80  


Met Leu Val Ile Met Asp Pro Asp Met Ile Lys Thr Val Leu Val Lys 
                85                  90                  95      


Glu Cys Tyr Ser Val Phe Thr Asn Gln Met Pro Leu Gly Pro Met Gly 
            100                 105                 110         


Phe Leu Lys Ser Ala Leu Ser Phe Ala Glu Asp Glu Glu Trp Lys Arg 
        115                 120                 125             


Ile Arg Thr Leu Leu Ser Pro Ala Phe Thr Ser Val Lys Phe Lys Glu 
    130                 135                 140                 


Met Val Pro Ile Ile Ser Gln Cys Gly Asp Met Leu Val Arg Ser Leu 
145                 150                 155                 160 


Arg Gln Glu Ala Glu Asn Ser Lys Ser Ile Asn Leu Lys Asp Phe Phe 
                165                 170                 175     


Gly Ala Tyr Thr Met Asp Val Ile Thr Gly Thr Leu Phe Gly Val Asn 
            180                 185                 190         


Leu Asp Ser Leu Asn Asn Pro Gln Asp Pro Phe Leu Lys Asn Met Lys 
        195                 200                 205             


Lys Leu Leu Lys Leu Asp Phe Leu Asp Pro Phe Leu Leu Leu Ile Ser 
    210                 215                 220                 


Leu Phe Pro Phe Leu Thr Pro Val Phe Glu Ala Leu Asn Ile Gly Leu 
225                 230                 235                 240 


Phe Pro Lys Asp Val Thr His Phe Leu Lys Asn Ser Ile Glu Arg Met 
                245                 250                 255     


Lys Glu Ser Arg Leu Lys Asp Lys Gln Lys His Arg Val Asp Phe Phe 
            260                 265                 270         


Gln Gln Met Ile Asp Ser Gln Asn Ser Lys Glu Thr Lys Ser His Lys 
        275                 280                 285             


Ala Leu Ser Asp Leu Glu Leu Val Ala Gln Ser Ile Ile Ile Ile Phe 
    290                 295                 300                 


Ala Ala Tyr Asp Thr Thr Ser Thr Thr Leu Pro Phe Ile Met Tyr Glu 
305                 310                 315                 320 


Leu Ala Thr His Pro Asp Val Gln Gln Lys Leu Gln Glu Glu Ile Asp 
                325                 330                 335     


Ala Val Leu Pro Asn Lys Ala Pro Val Thr Tyr Asp Ala Leu Val Gln 
            340                 345                 350         


Met Glu Tyr Leu Asp Met Val Val Asn Glu Thr Leu Arg Leu Phe Pro 
        355                 360                 365             


Val Val Ser Arg Val Thr Arg Val Cys Lys Lys Asp Ile Glu Ile Asn 
    370                 375                 380                 


Gly Val Phe Ile Pro Lys Gly Leu Ala Val Met Val Pro Ile Tyr Ala 
385                 390                 395                 400 


Leu His His Asp Pro Lys Tyr Trp Thr Glu Pro Glu Lys Phe Cys Pro 
                405                 410                 415     


Glu Arg Ser His 
            420 


<210>  5577
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  5577

Met Ala Ala Ile Ser Thr Ser Ile Pro Val Ile Ser Gln Pro Gln Phe 
1               5                   10                  15      


Thr Ala Met Asn Glu Pro Gln Cys Phe Tyr Asn Glu Ser Ile Ala Phe 
            20                  25                  30          


Phe Tyr Asn Arg Ser Gly Lys His Leu Ala Thr Glu Trp Asn Thr Val 
        35                  40                  45              


Ser Lys Leu Val Met Gly Leu Gly Ile Thr Val Cys Ile Phe Ile Met 
    50                  55                  60                  


Leu Ala Asn Leu Leu Val Met Val Ala Ile Tyr Val Asn Arg Arg Phe 
65                  70                  75                  80  


His Phe Pro Ile Tyr Tyr Leu Met Ala Asn Leu Ala Ala Ala Asp Phe 
                85                  90                  95      


Phe Ala Gly Leu Ala Tyr Phe Tyr Leu Met Phe Asn Thr Gly Pro Asn 
            100                 105                 110         


Thr Arg Arg Leu Thr Val Ser Thr Trp Leu Leu Arg Gln Gly Leu Ile 
        115                 120                 125             


Asp Thr Ser Leu Thr Ala Ser Val Ala Asn Leu Leu Ala Ile Ala Ile 
    130                 135                 140                 


Glu Arg His Ile Thr Val Phe Arg Met Gln Leu His Thr Arg Met Ser 
145                 150                 155                 160 


Asn Arg Arg Val Val Val Val Ile Val Val Ile Trp Thr Met Ala Ile 
                165                 170                 175     


Val Met Gly Ala Ile Pro Ser Val Gly Trp Asn Cys Ile Cys Asp Ile 
            180                 185                 190         


Glu Asn Cys Ser Asn Met Ala Pro Leu Tyr Ser Asp Ser Tyr Leu Val 
        195                 200                 205             


Phe Trp Ala Ile Phe Asn Leu Val Thr Phe Val Val Met Val Val Leu 
    210                 215                 220                 


Tyr Ala His Ile Phe Gly Tyr Val Arg Gln Arg Thr Met Arg Met Ser 
225                 230                 235                 240 


Arg His Ser Ser Gly Pro Arg Arg Asn Arg Asp Thr Met Met Ser Leu 
                245                 250                 255     


Leu Lys Thr Val Val Ile Val Leu Gly Ala Phe Ile Ile Cys Trp Thr 
            260                 265                 270         


Pro Gly Leu Val Leu Leu Leu Leu Asp Val Cys Cys Pro Gln Cys Asp 
        275                 280                 285             


Val Leu Ala Tyr Glu Lys Phe Phe Leu Leu Leu Ala Glu Phe Asn Ser 
    290                 295                 300                 


Ala Met Asn Pro Ile Ile Tyr Ser Tyr Arg Asp Lys Glu Met Ser Ala 
305                 310                 315                 320 


Thr Phe Arg Gln Ile Leu Cys Cys Gln Arg Ser Glu Asn Pro Thr Gly 
                325                 330                 335     


Pro Thr Glu Gly Ser Asp Arg Ser Ala Ser Ser Leu Asn His Thr Ile 
            340                 345                 350         


Leu Ala Gly Val His Ser Asn Asp His Ser Val Val 
        355                 360                 


<210>  5578
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  5578

Met Asp Arg Ala Ala Leu Leu Gly Leu Ala Arg Leu Cys Ala Leu Trp 
1               5                   10                  15      


Ala Ala Leu Leu Val Leu Phe Pro Tyr Gly Ala Gln Gly Asn Trp Met 
            20                  25                  30          


Trp Leu Gly Ile Ala Ser Phe Gly Val Pro Glu Lys Leu Gly Cys Ala 
        35                  40                  45              


Asn Leu Pro Leu Asn Ser Arg Gln Lys Glu Leu Cys Lys Arg Lys Pro 
    50                  55                  60                  


Tyr Leu Leu Pro Ser Ile Arg Glu Gly Ala Arg Leu Gly Ile Gln Glu 
65                  70                  75                  80  


Cys Gly Ser Gln Phe Arg His Glu Arg Trp Asn Cys Met Ile Thr Ala 
                85                  90                  95      


Ala Ala Thr Thr Ala Pro Met Gly Ala Ser Pro Leu Phe Gly Tyr Glu 
            100                 105                 110         


Leu Ser Ser Gly Thr Lys Glu Thr Ala Phe Ile Tyr Ala Val Met Ala 
        115                 120                 125             


Ala Gly Leu Val His Ser Val Thr Arg Ser Cys Ser Ala Gly Asn Met 
    130                 135                 140                 


Thr Glu Cys Ser Cys Asp Thr Thr Leu Gln Asn Gly Gly Ser Ala Ser 
145                 150                 155                 160 


Glu Gly Trp His Trp Gly Gly Cys Ser Asp Asp Val Gln Tyr Gly Met 
                165                 170                 175     


Trp Phe Ser Arg Lys Phe Leu Asp Phe Pro Ile Gly Asn Thr Thr Gly 
            180                 185                 190         


Lys Glu Asn Lys Val Leu Leu Ala Met Asn Leu His Asn Asn Glu Ala 
        195                 200                 205             


Gly Arg Gln Ala Val Ala Lys Leu Met Ser Val Asp Cys Arg Cys His 
    210                 215                 220                 


Gly Val Ser Gly Ser Cys Ala Val Lys Thr Cys Trp Lys Thr Met Ser 
225                 230                 235                 240 


Ser Phe Glu Lys Ile Gly His Leu Leu Lys Asp Lys Tyr Glu Asn Ser 
                245                 250                 255     


Ile Gln Ile Ser Asp Lys Thr Lys Arg Lys Met Arg Arg Arg Glu Lys 
            260                 265                 270         


Asp Gln Arg Lys Ile Pro Ile His Lys Asp Asp Leu Leu Tyr Val Asn 
        275                 280                 285             


Lys Ser Pro Asn Tyr Cys Val Glu Asp Lys Lys Leu Gly Ile Pro Gly 
    290                 295                 300                 


Thr Gln Gly Arg Glu Cys Asn Arg Thr Ser Glu Gly Ala Asp Gly Cys 
305                 310                 315                 320 


Asn Leu Leu Cys Cys Gly Arg Gly Tyr Asn Thr His Val Val Arg His 
                325                 330                 335     


Val Glu Arg Cys Glu Cys Lys Phe Ile Trp Cys Cys Tyr Val Arg Cys 
            340                 345                 350         


Arg Arg Cys Glu Ser Met Thr Asp Val His Thr Cys Lys 
        355                 360                 365 


<210>  5579
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  5579

Met Ala Asp Glu Lys Thr Phe Arg Ile Gly Phe Ile Val Leu Gly Leu 
1               5                   10                  15      


Phe Leu Leu Ala Leu Gly Thr Phe Leu Met Ser His Asp Arg Pro Gln 
            20                  25                  30          


Val Tyr Gly Thr Phe Tyr Ala Met Gly Ser Val Met Val Ile Gly Gly 
        35                  40                  45              


Ile Ile Trp Ser Met Cys Gln Cys Tyr Pro Lys Ile Thr Phe Val Pro 
    50                  55                  60                  


Ala Asp Ser Asp Phe Gln Gly Ile Leu Ser Pro Lys Ala Met Gly Leu 
65                  70                  75                  80  


Leu Glu Asn Gly Leu Ala Ala Glu Met Lys Ser Pro Ser Pro Gln Pro 
                85                  90                  95      


Pro Tyr Val Arg Leu Trp Glu Glu Ala Ala Tyr Asp Gln Ser Leu Pro 
            100                 105                 110         


Asp Phe Ser His Ile Gln Met Lys Val Met Ser Tyr Ser Glu Asp His 
        115                 120                 125             


Arg Ser Leu Leu Ala Pro Glu Met Gly Gln Pro Lys Leu Gly Thr Ser 
    130                 135                 140                 


Asp Gly Gly Glu Gly Gly Pro Gly Asp Val Gln Ala Trp Met Glu Ala 
145                 150                 155                 160 


Ala Val Val Ile His Lys Gly Ser Asp Glu Ser Glu Gly Glu Arg Arg 
                165                 170                 175     


Leu Thr Gln Ser Trp Pro Gly Pro Leu Ala Cys Pro Gln Gly Pro Ala 
            180                 185                 190         


Pro Leu Ala Ser Phe Gln Asp Asp Leu Asp Met Asp Ser Ser Glu Gly 
        195                 200                 205             


Ser Ser Pro Asn Ala Ser Pro His Asp Arg Glu Glu Ala Cys Ser Pro 
    210                 215                 220                 


Gln Gln Glu Pro Gln Gly Cys Arg Cys Pro Leu Asp Arg Phe Gln Asp 
225                 230                 235                 240 


Phe Ala Leu Ile Asp Ala Pro Thr Leu Glu Asp Glu Pro Gln Glu Gly 
                245                 250                 255     


Gln Gln Trp Glu Ile Ala Leu Pro Asn Asn Trp Gln Arg Tyr Pro Arg 
            260                 265                 270         


Thr Lys Val Glu Glu Lys Glu Ala Ser Asp Thr Gly Gly Glu Glu Pro 
        275                 280                 285             


Glu Lys Glu Glu Glu Asp Leu Tyr Tyr Gly Leu Pro Asp Gly Ala Gly 
    290                 295                 300                 


Asp Leu Leu Pro Asp Lys Glu Leu Gly Phe Glu Pro Asp Thr Gln Gly 
305                 310                 315                 320 


<210>  5580
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  5580

Met Lys Val Glu Phe Ala Pro Leu Asn Ile Gln Leu Ala Arg Arg Leu 
1               5                   10                  15      


Gln Thr Val Ala Val Leu Gln Trp Val Leu Lys Tyr Leu Leu Leu Gly 
            20                  25                  30          


Pro Met Ser Ile Gly Ile Thr Val Met Leu Ile Ile His Asn Tyr Leu 
        35                  40                  45              


Phe Leu Tyr Ile Pro Tyr Leu Met Trp Leu Tyr Phe Asp Trp His Thr 
    50                  55                  60                  


Pro Glu Arg Gly Gly Arg Arg Ser Ser Trp Ile Lys Asn Trp Thr Leu 
65                  70                  75                  80  


Trp Lys His Phe Lys Asp Tyr Phe Pro Ile His Leu Ile Lys Thr Gln 
                85                  90                  95      


Asp Leu Asp Pro Ser His Asn Tyr Ile Phe Gly Phe His Pro His Gly 
            100                 105                 110         


Ile Met Ala Val Gly Ala Phe Gly Asn Phe Ser Val Asn Tyr Ser Asp 
        115                 120                 125             


Phe Lys Asp Leu Phe Pro Gly Phe Thr Ser Tyr Leu His Val Leu Pro 
    130                 135                 140                 


Leu Trp Phe Trp Cys Pro Val Phe Arg Glu Tyr Val Met Ser Val Gly 
145                 150                 155                 160 


Leu Val Ser Val Ser Lys Lys Ser Val Ser Tyr Met Val Ser Lys Glu 
                165                 170                 175     


Gly Gly Gly Asn Ile Ser Val Ile Val Leu Gly Gly Ala Lys Glu Ser 
            180                 185                 190         


Leu Asp Ala His Pro Gly Lys Phe Thr Leu Phe Ile Arg Gln Arg Lys 
        195                 200                 205             


Gly Phe Val Lys Ile Ala Leu Thr His Gly Ala Ser Leu Val Pro Val 
    210                 215                 220                 


Val Ser Phe Gly Glu Asn Glu Leu Phe Lys Gln Thr Asp Asn Pro Glu 
225                 230                 235                 240 


Gly Ser Trp Ile Arg Thr Val Gln Asn Lys Leu Gln Lys Ile Met Gly 
                245                 250                 255     


Phe Ala Leu Pro Leu Phe His Ala Arg Gly Val Phe Gln Tyr Asn Phe 
            260                 265                 270         


Gly Leu Met Thr Tyr Arg Lys Ala Ile His Thr Val Val Gly Arg Pro 
        275                 280                 285             


Ile Pro Val Arg Gln Thr Leu Asn Pro Thr Gln Glu Gln Ile Glu Glu 
    290                 295                 300                 


Leu His Gln Thr Tyr Met Glu Glu Leu Arg Lys Leu Phe Glu Glu His 
305                 310                 315                 320 


Lys Gly Lys Tyr Gly Ile Pro Glu His Glu Thr Leu Val Leu Lys 
                325                 330                 335 


<210>  5581
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  5581

Met Ser Ser Thr Ser Ser Lys Arg Ala Pro Thr Thr Ala Thr Gln Arg 
1               5                   10                  15      


Leu Lys Gln Asp Tyr Leu Arg Ile Lys Lys Asp Pro Val Pro Tyr Ile 
            20                  25                  30          


Cys Ala Glu Pro Leu Pro Ser Asn Ile Leu Glu Trp His Tyr Val Val 
        35                  40                  45              


Arg Gly Pro Glu Met Thr Pro Tyr Glu Gly Gly Tyr Tyr His Gly Lys 
    50                  55                  60                  


Leu Ile Phe Pro Arg Glu Phe Pro Phe Lys Pro Pro Ser Ile Tyr Met 
65                  70                  75                  80  


Ile Thr Pro Asn Gly Arg Phe Lys Cys Asn Thr Arg Leu Cys Leu Ser 
                85                  90                  95      


Ile Thr Asp Phe His Pro Asp Thr Trp Asn Pro Ala Trp Ser Val Ser 
            100                 105                 110         


Thr Ile Leu Thr Gly Leu Leu Ser Phe Met Val Glu Lys Gly Pro Thr 
        115                 120                 125             


Leu Gly Ser Ile Glu Thr Ser Asp Phe Thr Lys Arg Gln Leu Ala Val 
    130                 135                 140                 


Gln Ser Leu Ala Phe Asn Leu Lys Asp Lys Val Phe Cys Glu Leu Phe 
145                 150                 155                 160 


Pro Glu Val Val Glu Glu Ile Lys Gln Lys Gln Lys Ala Gln Asp Glu 
                165                 170                 175     


Leu Ser Ser Arg Pro Gln Thr Leu Pro Leu Pro Asp Val Val Pro Asp 
            180                 185                 190         


Gly Glu Thr His Leu Val Gln Asn Gly Ile Gln Leu Leu Asn Gly His 
        195                 200                 205             


Ala Pro Gly Ala Val Pro Asn Leu Ala Gly Leu Gln Gln Ala Asn Arg 
    210                 215                 220                 


His His Gly Leu Leu Gly Gly Ala Leu Ala Asn Leu Phe Val Ile Val 
225                 230                 235                 240 


Gly Phe Ala Ala Phe Ala Tyr Thr Val Lys Tyr Val Leu Arg Ser Ile 
                245                 250                 255     


Ala Gln Glu 
            


<210>  5582
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  5582

Met Val Ala Glu Arg Ser Pro Ala Arg Ser Pro Gly Ser Trp Leu Phe 
1               5                   10                  15      


Pro Gly Leu Trp Leu Leu Val Leu Ser Gly Pro Gly Gly Leu Leu Arg 
            20                  25                  30          


Ala Gln Glu Gln Pro Ser Cys Arg Arg Ala Phe Asp Leu Tyr Phe Val 
        35                  40                  45              


Leu Asp Lys Ser Gly Ser Val Ala Asn Asn Trp Ile Glu Ile Tyr Asn 
    50                  55                  60                  


Phe Val Gln Gln Leu Ala Glu Arg Phe Val Ser Pro Glu Met Arg Leu 
65                  70                  75                  80  


Ser Phe Ile Val Phe Ser Ser Gln Ala Thr Ile Ile Leu Pro Leu Thr 
                85                  90                  95      


Gly Asp Arg Gly Lys Ile Ser Lys Gly Leu Glu Asp Leu Lys Arg Val 
            100                 105                 110         


Ser Pro Val Gly Glu Thr Tyr Ile His Glu Gly Leu Lys Leu Ala Asn 
        115                 120                 125             


Glu Gln Ile Gln Lys Ala Gly Gly Leu Lys Thr Ser Ser Ile Ile Ile 
    130                 135                 140                 


Ala Leu Thr Asp Gly Lys Leu Asp Gly Leu Val Pro Ser Tyr Ala Glu 
145                 150                 155                 160 


Lys Glu Ala Lys Ile Ser Arg Ser Leu Gly Ala Ser Val Tyr Cys Val 
                165                 170                 175     


Gly Val Leu Asp Phe Glu Gln Ala Gln Leu Glu Arg Ile Ala Asp Ser 
            180                 185                 190         


Lys Glu Gln Val Phe Pro Val Lys Gly Gly Phe Gln Ala Leu Lys Gly 
        195                 200                 205             


Ile Ile Asn Ser Ile Leu Ala Gln Ser Cys Thr Glu Ile Leu Glu Leu 
    210                 215                 220                 


Gln Pro Ser Ser Val Cys Val Gly Glu Glu Phe Gln Ile Val Leu Ser 
225                 230                 235                 240 


Gly Arg Gly Phe Met Leu Gly Ser Arg Asn Gly Ser Val Leu Cys Thr 
                245                 250                 255     


Tyr Thr Val Asn Glu Thr Tyr Thr Thr Ser Val Lys Pro Val Ser Val 
            260                 265                 270         


Gln Leu Asn Ser Met Leu Cys Pro Ala Pro Ile Leu Asn Lys Ala Gly 
        275                 280                 285             


Glu Thr Leu Asp Val Ser Val Ser Phe Asn Gly Gly Lys Ser Val Ile 
    290                 295                 300                 


Ser Gly Ser Leu Ile Val Thr Ala Thr Glu Cys Ser Asn Gly Ile Ala 
305                 310                 315                 320 


Ala Ile Ile Val Ile Leu Val Leu Leu Leu Leu Leu Gly Ile Gly Leu 
                325                 330                 335     


Met Trp Trp Phe Trp Pro Leu Cys Cys Lys Val Val Ile Lys Asp Pro 
            340                 345                 350         


Pro Pro Pro Pro Ala Pro Ala Pro Lys Glu Glu Glu Glu Glu Pro Leu 
        355                 360                 365             


Pro Thr Lys Lys Trp Pro Thr Val Asp Ala Ser Tyr Tyr Gly Gly Arg 
    370                 375                 380                 


Gly Val Gly Gly Ile Lys Arg Met Glu Val Arg Trp Gly Asp Lys Gly 
385                 390                 395                 400 


Ser Thr Glu Glu Gly Ala Arg Leu Glu Lys Ala Lys Asn Ala Val Val 
                405                 410                 415     


Lys Ile Pro Glu Glu Thr Glu Glu Pro Ile Arg Pro Arg Pro Pro Arg 
            420                 425                 430         


Pro Lys Pro Thr His Gln Pro Pro Gln Thr Lys Trp Tyr Thr Pro Ile 
        435                 440                 445             


Lys Gly Arg Leu Asp Ala Leu Trp Ala Leu Leu Arg Arg Gln Tyr Asp 
    450                 455                 460                 


Arg Val Ser Leu Met Arg Pro Gln Glu Gly Asp Glu Gly Arg Cys Ile 
465                 470                 475                 480 


Asn Phe Ser Arg Val Pro Ser Gln 
                485             


<210>  5583
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  5583

Met Asn Trp Lys Val Leu Glu His Val Pro Leu Leu Leu Tyr Ile Leu 
1               5                   10                  15      


Ala Ala Lys Thr Leu Ile Leu Cys Leu Thr Phe Ala Gly Val Lys Met 
            20                  25                  30          


Tyr Gln Arg Lys Arg Leu Glu Ala Lys Gln Gln Lys Leu Glu Ala Glu 
        35                  40                  45              


Arg Lys Lys Gln Ser Glu Lys Lys Asp Asn 
    50                  55              


<210>  5584
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  5584

Met Arg Pro Leu Ala Gly Gly Leu Leu Lys Val Val Phe Val Val Phe 
1               5                   10                  15      


Ala Ser Leu Cys Ala Trp Tyr Ser Gly Tyr Leu Leu Ala Glu Leu Ile 
            20                  25                  30          


Pro Asp Ala Pro Leu Ser Ser Ala Ala Tyr Ser Ile Arg Ser Ile Gly 
        35                  40                  45              


Glu Arg Pro Val Leu Lys Ala Pro Val Pro Lys Arg Gln Lys Cys Asp 
    50                  55                  60                  


His Trp Thr Pro Cys Pro Ser Asp Thr Tyr Ala Tyr Arg Leu Leu Ser 
65                  70                  75                  80  


Gly Gly Gly Arg Ser Lys Tyr Ala Lys Ile Cys Phe Glu Asp Asn Leu 
                85                  90                  95      


Leu Met Gly Glu Gln Leu Gly Asn Val Ala Arg Gly Ile Asn Ile Ala 
            100                 105                 110         


Ile Val Asn Tyr Val Thr Gly Asn Val Thr Ala Thr Arg Cys Phe Asp 
        115                 120                 125             


Met Tyr Glu Gly Asp Asn Ser Gly Pro Met Thr Lys Phe Ile Gln Ser 
    130                 135                 140                 


Ala Ala Pro Lys Ser Leu Leu Phe Met Val Thr Tyr Asp Asp Gly Ser 
145                 150                 155                 160 


Thr Arg Leu Asn Asn Asp Ala Lys Asn Ala Ile Glu Ala Leu Gly Ser 
                165                 170                 175     


Lys Glu Ile Arg Asn Met Lys Phe Arg Ser Ser Trp Val Phe Ile Ala 
            180                 185                 190         


Ala Lys Gly Leu Glu Leu Pro Ser Glu Ile Gln Arg Glu Lys Ile Asn 
        195                 200                 205             


His Ser Asp Ala Lys Asn Asn Arg Tyr Ser Gly Trp Pro Ala Glu Ile 
    210                 215                 220                 


Gln Ile Glu Gly Cys Ile Pro Lys Glu Arg Ser 
225                 230                 235 


<210>  5585
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  5585

Met Leu Leu Pro Gly Arg Ala Arg Gln Pro Pro Thr Pro Gln Pro Val 
1               5                   10                  15      


Gln His Pro Gly Leu Arg Arg Gln Val Glu Pro Pro Gly Gln Leu Leu 
            20                  25                  30          


Arg Leu Phe Tyr Cys Thr Val Leu Val Cys Ser Lys Glu Ile Ser Ala 
        35                  40                  45              


Leu Thr Asp Phe Ser Gly Tyr Leu Thr Lys Leu Leu Gln Asn His Thr 
    50                  55                  60                  


Thr Tyr Ala Cys Asp Gly Asp Tyr Leu Asn Leu Gln Cys Pro Arg His 
65                  70                  75                  80  


Ser Thr Ile Ser Val Gln Ser Ala Phe Tyr Gly Gln Asp Tyr Gln Met 
                85                  90                  95      


Cys Ser Ser Gln Lys Pro Ala Ser Gln Arg Glu Asp Ser Leu Thr Cys 
            100                 105                 110         


Val Ala Ala Thr Thr Phe Gln Lys Val Leu Asp Glu Cys Gln Asn Gln 
        115                 120                 125             


Arg Ala Cys His Leu Leu Val Asn Ser Arg Val Phe Gly Pro Asp Leu 
    130                 135                 140                 


Cys Pro Gly Ser Ser Lys Tyr Leu Leu Val Ser Phe Lys Cys Gln Pro 
145                 150                 155                 160 


Asn Glu Leu Lys Asn Lys Thr Val Cys Glu Asp Gln Glu Leu Lys Leu 
                165                 170                 175     


His Cys His Glu Ser Lys Phe Leu Asn Ile Tyr Ser Ala Thr Tyr Gly 
            180                 185                 190         


Arg Arg Thr Gln Glu Arg Asp Ile Cys Ser Ser Lys Ala Glu Arg Leu 
        195                 200                 205             


Pro Pro Phe Asp Cys Leu Ser Tyr Ser Ala Leu Gln Val Leu Ser Arg 
    210                 215                 220                 


Arg Cys Tyr Gly Lys Gln Arg Cys Lys Ile Ile Val Asn Asn His His 
225                 230                 235                 240 


Phe Gly Ser Pro Cys Leu Pro Gly Val Lys Lys Tyr Leu Thr Val Thr 
                245                 250                 255     


Tyr Ala Cys Val Pro Lys Asn Ile Leu Thr Ala Ile Asp Pro Ala Ile 
            260                 265                 270         


Ala Asn Leu Lys Pro Ser Leu Lys Gln Lys Asp Gly Glu Tyr Gly Ile 
        275                 280                 285             


Asn Phe Asp Pro Ser Gly Ser Lys Val Leu Arg Lys Asp Gly Ile Leu 
    290                 295                 300                 


Val Ser Asn Ser Leu Ala Ala Phe Ala Tyr Ile Arg Ala His Pro Glu 
305                 310                 315                 320 


Arg Ala Ala Leu Leu Phe Val Ser Ser Val Cys Ile Gly Leu Ala Leu 
                325                 330                 335     


Thr Leu Cys Ala Leu Val Ile Arg Glu Ser Cys Ala Lys Asp Phe Arg 
            340                 345                 350         


Asp Leu Gln Leu Gly Arg Glu Gln Leu Val Pro Gly Ser Asp Lys Val 
        355                 360                 365             


Glu Glu Asp Ser Glu Asp Glu Glu Glu Glu Glu Asp Pro Ser Glu Ser 
    370                 375                 380                 


Asp Phe Pro Gly Glu Leu Ser Gly Phe Cys Arg Thr Ser Tyr Pro Ile 
385                 390                 395                 400 


Tyr Ser Ser Ile Glu Ala Ala Glu Leu Ala Glu Arg Ile Glu Arg Arg 
                405                 410                 415     


Glu Gln Ile Ile Gln Glu Ile Trp Met Asn Ser Gly Leu Asp Thr Ser 
            420                 425                 430         


Leu Pro Arg Asn Met Gly Gln Phe Tyr 
        435                 440     


<210>  5586
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  5586

Met His Arg Asn Phe Arg Lys Trp Ile Phe Tyr Val Phe Leu Cys Phe 
1               5                   10                  15      


Gly Val Leu Tyr Val Lys Leu Gly Ala Leu Ser Ser Val Val Ala Leu 
            20                  25                  30          


Gly Ala Asn Ile Ile Cys Asn Lys Ile Pro Gly Leu Ala Pro Arg Gln 
        35                  40                  45              


Arg Ala Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile Gly Glu 
    50                  55                  60                  


Gly Ala Gln Met Gly Ile Asn Glu Cys Gln Tyr Gln Phe Arg Phe Gly 
65                  70                  75                  80  


Arg Trp Asn Cys Ser Ala Leu Gly Glu Lys Thr Val Phe Gly Gln Glu 
                85                  90                  95      


Leu Arg Val Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Thr Ala 
            100                 105                 110         


Ala Gly Val Ala His Ala Val Thr Ala Ala Cys Ser Gln Gly Asn Leu 
        115                 120                 125             


Ser Asn Cys Gly Cys Asp Arg Glu Lys Gln Gly Tyr Tyr Asn Gln Ala 
    130                 135                 140                 


Glu Gly Trp Lys Trp Gly Gly Cys Ser Ala Asp Val Arg Tyr Gly Ile 
145                 150                 155                 160 


Asp Phe Ser Arg Arg Phe Val Asp Ala Arg Glu Ile Lys Lys Asn Ala 
                165                 170                 175     


Arg Arg Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Val Leu 
            180                 185                 190         


Glu Asp Arg Met Gln Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser 
        195                 200                 205             


Cys Thr Thr Lys Thr Cys Trp Thr Thr Leu Pro Lys Phe Arg Glu Val 
    210                 215                 220                 


Gly His Leu Leu Lys Glu Lys Tyr Asn Ala Ala Val Gln Val Glu Val 
225                 230                 235                 240 


Val Arg Ala Ser Arg Leu Arg Gln Pro Thr Phe Leu Arg Ile Lys Gln 
                245                 250                 255     


Leu Arg Ser Tyr Gln Lys Pro Met Glu Thr Asp Leu Val Tyr Ile Glu 
            260                 265                 270         


Lys Ser Pro Asn Tyr Cys Glu Glu Asp Ala Ala Thr Gly Ser Val Gly 
        275                 280                 285             


Thr Gln Gly Arg Leu Cys Asn Arg Thr Ser Pro Gly Ala Asp Gly Cys 
    290                 295                 300                 


Asp Thr Met Cys Cys Gly Arg Gly Tyr Asn Thr His Gln Tyr Thr Lys 
305                 310                 315                 320 


Val Trp Gln Cys Asn Cys Lys Phe His Trp Cys Cys Phe Val Lys Cys 
                325                 330                 335     


Asn Thr Cys Ser Glu Arg Thr Glu Val Phe Thr Cys Lys 
            340                 345                 


<210>  5587
<211>  924
<212>  PRT
<213>  Homo sapiens

<400>  5587

Met Ala Trp Leu Arg Leu Gln Pro Leu Thr Ser Ala Phe Leu His Phe 
1               5                   10                  15      


Gly Leu Val Thr Phe Val Leu Phe Leu Asn Gly Leu Arg Ala Glu Ala 
            20                  25                  30          


Gly Gly Ser Gly Asp Val Pro Ser Thr Gly Gln Asn Asn Glu Ser Cys 
        35                  40                  45              


Ser Gly Ser Ser Asp Cys Lys Glu Gly Val Ile Leu Pro Ile Trp Tyr 
    50                  55                  60                  


Pro Glu Asn Pro Ser Leu Gly Asp Lys Ile Ala Arg Val Ile Val Tyr 
65                  70                  75                  80  


Phe Val Ala Leu Ile Tyr Met Phe Leu Gly Val Ser Ile Ile Ala Asp 
                85                  90                  95      


Arg Phe Met Ala Ser Ile Glu Val Ile Thr Ser Gln Glu Arg Glu Val 
            100                 105                 110         


Thr Ile Lys Lys Pro Asn Gly Glu Thr Ser Thr Thr Thr Ile Arg Val 
        115                 120                 125             


Trp Asn Glu Thr Val Ser Asn Leu Thr Leu Met Ala Leu Gly Ser Ser 
    130                 135                 140                 


Ala Pro Glu Ile Leu Leu Ser Leu Ile Glu Val Cys Gly His Gly Phe 
145                 150                 155                 160 


Ile Ala Gly Asp Leu Gly Pro Ser Thr Ile Val Gly Ser Ala Ala Phe 
                165                 170                 175     


Asn Met Phe Ile Ile Ile Gly Ile Cys Val Tyr Val Ile Pro Asp Gly 
            180                 185                 190         


Glu Thr Arg Lys Ile Lys His Leu Arg Val Phe Phe Ile Thr Ala Ala 
        195                 200                 205             


Trp Ser Ile Phe Ala Tyr Ile Trp Leu Tyr Met Ile Leu Ala Val Phe 
    210                 215                 220                 


Ser Pro Gly Val Val Gln Val Trp Glu Gly Leu Leu Thr Leu Phe Phe 
225                 230                 235                 240 


Phe Pro Val Cys Val Leu Leu Ala Trp Val Ala Asp Lys Arg Leu Leu 
                245                 250                 255     


Phe Tyr Lys Tyr Met His Lys Lys Tyr Arg Thr Asp Lys His Arg Gly 
            260                 265                 270         


Ile Ile Ile Glu Thr Glu Gly Asp His Pro Lys Gly Ile Glu Met Asp 
        275                 280                 285             


Gly Lys Met Met Asn Ser His Phe Leu Asp Gly Asn Leu Val Pro Leu 
    290                 295                 300                 


Glu Gly Lys Glu Val Asp Glu Ser Arg Arg Glu Met Ile Arg Ile Leu 
305                 310                 315                 320 


Lys Asp Leu Lys Gln Lys His Pro Glu Lys Asp Leu Asp Gln Leu Val 
                325                 330                 335     


Glu Met Ala Asn Tyr Tyr Ala Leu Ser His Gln Gln Lys Ser Arg Ala 
            340                 345                 350         


Phe Tyr Arg Ile Gln Ala Thr Arg Met Met Thr Gly Ala Gly Asn Ile 
        355                 360                 365             


Leu Lys Lys His Ala Ala Glu Gln Ala Lys Lys Ala Ser Ser Met Ser 
    370                 375                 380                 


Glu Val His Thr Asp Glu Pro Glu Asp Phe Ile Ser Lys Val Phe Phe 
385                 390                 395                 400 


Asp Pro Cys Ser Tyr Gln Cys Leu Glu Asn Cys Gly Ala Val Leu Leu 
                405                 410                 415     


Thr Val Val Arg Lys Gly Gly Asp Met Ser Lys Thr Met Tyr Val Asp 
            420                 425                 430         


Tyr Lys Thr Glu Asp Gly Ser Ala Asn Ala Gly Ala Asp Tyr Glu Phe 
        435                 440                 445             


Thr Glu Gly Thr Val Val Leu Lys Pro Gly Glu Thr Gln Lys Glu Phe 
    450                 455                 460                 


Ser Val Gly Ile Ile Asp Asp Asp Ile Phe Glu Glu Asp Glu His Phe 
465                 470                 475                 480 


Phe Val Arg Leu Ser Asn Val Arg Ile Glu Glu Glu Gln Pro Glu Glu 
                485                 490                 495     


Gly Met Pro Pro Ala Ile Phe Asn Ser Leu Pro Leu Pro Arg Ala Val 
            500                 505                 510         


Leu Ala Ser Pro Cys Val Ala Thr Val Thr Ile Leu Asp Asp Asp His 
        515                 520                 525             


Ala Gly Ile Phe Thr Phe Glu Cys Asp Thr Ile His Val Ser Glu Ser 
    530                 535                 540                 


Ile Gly Val Met Glu Val Lys Val Leu Arg Thr Ser Gly Ala Arg Gly 
545                 550                 555                 560 


Thr Val Ile Val Pro Phe Arg Thr Val Glu Gly Thr Ala Lys Gly Gly 
                565                 570                 575     


Gly Glu Asp Phe Glu Asp Thr Tyr Gly Glu Leu Glu Phe Lys Asn Asp 
            580                 585                 590         


Glu Thr Val Lys Thr Ile Arg Val Lys Ile Val Asp Glu Glu Glu Tyr 
        595                 600                 605             


Glu Arg Gln Glu Asn Phe Phe Ile Ala Leu Gly Glu Pro Lys Trp Met 
    610                 615                 620                 


Glu Arg Gly Ile Ser Ala Leu Leu Leu Ser Pro Asp Arg Lys Leu Thr 
625                 630                 635                 640 


Met Glu Glu Glu Glu Ala Lys Arg Ile Ala Glu Met Gly Lys Pro Val 
                645                 650                 655     


Leu Gly Glu His Pro Lys Leu Glu Val Ile Ile Glu Glu Ser Tyr Glu 
            660                 665                 670         


Phe Lys Thr Thr Val Asp Lys Leu Ile Lys Lys Thr Asn Leu Ala Leu 
        675                 680                 685             


Val Val Gly Thr His Ser Trp Arg Asp Gln Phe Met Glu Ala Ile Thr 
    690                 695                 700                 


Val Ser Ala Ala Gly Asp Glu Asp Glu Asp Glu Ser Gly Glu Glu Arg 
705                 710                 715                 720 


Leu Pro Ser Cys Phe Asp Tyr Val Met His Phe Leu Thr Val Phe Trp 
                725                 730                 735     


Lys Val Leu Phe Ala Cys Val Pro Pro Thr Glu Tyr Cys His Gly Trp 
            740                 745                 750         


Ala Cys Phe Ala Val Ser Ile Leu Ile Ile Gly Met Leu Thr Ala Ile 
        755                 760                 765             


Ile Gly Asp Leu Ala Ser His Phe Gly Cys Thr Ile Gly Leu Lys Asp 
    770                 775                 780                 


Ser Val Thr Ala Val Val Phe Val Ala Phe Gly Thr Ser Val Pro Asp 
785                 790                 795                 800 


Thr Phe Ala Ser Lys Ala Ala Ala Leu Gln Asp Val Tyr Ala Asp Ala 
                805                 810                 815     


Ser Ile Gly Asn Val Thr Gly Ser Asn Ala Val Asn Val Phe Leu Gly 
            820                 825                 830         


Ile Gly Leu Ala Trp Ser Val Ala Ala Ile Tyr Trp Ala Leu Gln Gly 
        835                 840                 845             


Gln Glu Phe His Val Ser Ala Gly Thr Leu Ala Phe Ser Val Thr Leu 
    850                 855                 860                 


Phe Thr Ile Phe Ala Phe Val Cys Ile Ser Val Leu Leu Tyr Arg Arg 
865                 870                 875                 880 


Arg Pro His Leu Gly Gly Glu Leu Gly Gly Pro Arg Gly Cys Lys Leu 
                885                 890                 895     


Ala Thr Thr Trp Leu Phe Val Ser Leu Trp Leu Leu Tyr Ile Leu Phe 
            900                 905                 910         


Ala Thr Leu Glu Ala Tyr Cys Tyr Ile Lys Gly Phe 
        915                 920                 


<210>  5588
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  5588

Met Pro Gln Leu Cys Thr Arg Ala Ser Ser Ser Glu Ile Pro Gly Arg 
1               5                   10                  15      


Leu Leu Thr Thr Leu Gln Ser Ala Gln Gly Gln Lys Phe Leu His Phe 
            20                  25                  30          


Ala Lys Ser Asp Ser Phe Leu Asp Asp Ile Phe Ala Ala Trp Met Ala 
        35                  40                  45              


Gln Arg Leu Lys Thr His Leu Leu Thr Glu Thr Trp Gln Arg Lys Arg 
    50                  55                  60                  


Gln Glu Leu Pro Ser Asn Cys Ser Leu Pro Tyr His Val Tyr Asn Ile 
65                  70                  75                  80  


Lys Ala Ile Lys Leu Ser Arg His Ser Tyr Phe Ser Ser Tyr Gln Asp 
                85                  90                  95      


His Ala Lys Trp Cys Ile Ser Gln Lys Gly Thr Lys Asn Arg Trp Thr 
            100                 105                 110         


Cys Ile Gly Asp Leu Asn Arg Ser Pro His Gln Ala Phe Arg Ser Gly 
        115                 120                 125             


Gly Phe Ile Cys Thr Gln Asn Trp Gln Ile Tyr Gln Ala Phe Gln Gly 
    130                 135                 140                 


Leu Val Leu Tyr Tyr Glu Ser Cys Lys 
145                 150             


<210>  5589
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  5589

Met Gln Arg Leu Leu Phe Pro Pro Leu Arg Ala Leu Lys Gly Arg Gln 
1               5                   10                  15      


Tyr Leu Pro Leu Leu Ala Pro Arg Ala Ala Pro Arg Ala Gln Cys Asp 
            20                  25                  30          


Cys Ile Arg Arg Pro Leu Arg Pro Gly Gln Tyr Ser Thr Ile Ser Glu 
        35                  40                  45              


Val Ala Leu Gln Ser Gly Arg Gly Thr Val Ser Leu Pro Ser Lys Ala 
    50                  55                  60                  


Ala Glu Arg Val Val Gly Arg Trp Leu Leu Val Cys Ser Gly Thr Val 
65                  70                  75                  80  


Ala Gly Ala Val Ile Leu Gly Gly Val Thr Arg Leu Thr Glu Ser Gly 
                85                  90                  95      


Leu Ser Met Val Asp Trp His Leu Ile Lys Glu Met Lys Pro Pro Thr 
            100                 105                 110         


Ser Gln Glu Glu Trp Glu Ala Glu Phe Gln Arg Tyr Gln Gln Phe Pro 
        115                 120                 125             


Glu Phe Lys Ile Leu Asn His Asp Met Thr Leu Thr Glu Phe Lys Phe 
    130                 135                 140                 


Ile Trp Tyr Met Glu Tyr Ser His Arg Met Trp Gly Arg Leu Val Gly 
145                 150                 155                 160 


Leu Val Tyr Ile Leu Pro Ala Ala Tyr Phe Trp Arg Lys Gly Trp Leu 
                165                 170                 175     


Ser Arg Gly Met Lys Gly Arg Val Leu Ala Leu Cys Gly Leu Val Cys 
            180                 185                 190         


Phe Gln Gly Leu Leu Gly Trp Tyr Met Val Lys Ser Gly Leu Glu Glu 
        195                 200                 205             


Lys Ser Asp Ser His Asp Ile Pro Arg Val Ser Gln Tyr Arg Leu Ala 
    210                 215                 220                 


Ala His Leu Gly Ser Ala Leu Val Leu Tyr Cys Ala Ser Leu Trp Thr 
225                 230                 235                 240 


Ser Leu Ser Leu Leu Leu Pro Pro His Lys Leu Pro Glu Thr His Gln 
                245                 250                 255     


Leu Leu Gln Leu Arg Arg Phe Ala His Gly Thr Ala Gly Leu Val Phe 
            260                 265                 270         


Leu Thr Ala Leu Ser Gly Ala Phe Val Ala Gly Leu Asp Ala Gly Leu 
        275                 280                 285             


Val Tyr Asn Ser Phe Pro Lys Met Gly Glu Ser Trp Ile Pro Glu Asp 
    290                 295                 300                 


Leu Phe Thr Phe Ser Pro Ile Leu Arg Asn Val Phe Glu Asn Pro Thr 
305                 310                 315                 320 


Met Val Gln Phe Asp His Arg Ile Leu Gly Ile Thr Ser Val Thr Ala 
                325                 330                 335     


Ile Thr Val Leu Tyr Phe Leu Ser Arg Arg Ile Pro Leu Pro Arg Arg 
            340                 345                 350         


Thr Lys Met Ala Ala Val Thr Leu Leu Ala Leu Ala Tyr Thr Gln Val 
        355                 360                 365             


Gly Leu Gly Ile Ser Thr Leu Leu Met Tyr Val Pro Thr Pro Leu Ala 
    370                 375                 380                 


Ala Thr His Gln Ser Gly Ser Leu Ala Leu Leu Thr Gly Ala Leu Trp 
385                 390                 395                 400 


Leu Met Asn Glu Leu Arg Arg Val Pro Lys 
                405                 410 


<210>  5590
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  5590

Met Val Leu Gly Gly Cys Pro Val Ser Tyr Leu Leu Leu Cys Gly Gln 
1               5                   10                  15      


Ala Ala Leu Leu Leu Gly Asn Leu Leu Leu Leu His Cys Val Ser Arg 
            20                  25                  30          


Ser His Ser Gln Asn Ala Thr Ala Glu Pro Glu Leu Thr Ser Ala Gly 
        35                  40                  45              


Ala Ala Gln Pro Glu Gly Pro Gly Gly Ala Ala Ser Trp Glu Tyr Gly 
    50                  55                  60                  


Asp Pro His Ser Pro Val Ile Leu Cys Ser Tyr Leu Pro Asp Glu Phe 
65                  70                  75                  80  


Ile Glu Cys Glu Asp Pro Val Asp His Val Gly Asn Ala Thr Ala Ser 
                85                  90                  95      


Gln Glu Leu Gly Tyr Gly Cys Leu Lys Phe Gly Gly Gln Ala Tyr Ser 
            100                 105                 110         


Asp Val Glu His Thr Ser Val Gln Cys His Ala Leu Asp Gly Ile Glu 
        115                 120                 125             


Cys Ala Ser Pro Arg Thr Phe Leu Arg Glu Asn Lys Pro Cys Ile Lys 
    130                 135                 140                 


Tyr Thr Gly His Tyr Phe Ile Thr Thr Leu Leu Tyr Ser Phe Phe Leu 
145                 150                 155                 160 


Gly Cys Phe Gly Val Asp Arg Phe Cys Leu Gly His Thr Gly Thr Ala 
                165                 170                 175     


Val Gly Lys Leu Leu Thr Leu Gly Gly Leu Gly Ile Trp Trp Phe Val 
            180                 185                 190         


Asp Leu Ile Leu Leu Ile Thr Gly Gly Leu Met Pro Ser Asp Gly Ser 
        195                 200                 205             


Asn Trp Cys Thr Val Tyr 
    210                 


<210>  5591
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  5591

Met Glu Ser Ala Ala Ala Leu His Phe Ser Arg Pro Ala Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Ala Gln Phe Ile Val 
            20                  25                  30          


Val Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr 
        35                  40                  45              


Leu Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val 
    50                  55                  60                  


Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly 
65                  70                  75                  80  


Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr 
                85                  90                  95      


Thr Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile 
            100                 105                 110         


His Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln 
        115                 120                 125             


Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Val Ala Gly 
    130                 135                 140                 


Leu Gly Ser Lys Pro Leu Ile Ser Met Arg Gly His Glu Asp Gly Gly 
145                 150                 155                 160 


Ile Arg Leu Glu Cys Ile Ser Arg Gly Trp Tyr Pro Lys Pro Leu Thr 
                165                 170                 175     


Val Trp Arg Asp Pro Tyr Gly Gly Val Ala Pro Ala Leu Lys Glu Val 
            180                 185                 190         


Ser Met Pro Asp Ala Asp Gly Leu Phe Met Val Thr Thr Ala Val Ile 
        195                 200                 205             


Ile Arg Asp Lys Ser Val Arg Asn Met Ser Cys Ser Ile Asn Asn Thr 
    210                 215                 220                 


Leu Leu Gly Gln Lys Lys Glu Ser Val Ile Phe Ile Pro Glu Ser Phe 
225                 230                 235                 240 


Met Pro Ser Val Ser Pro Cys Ala Val Ala Leu Pro Ile Ile Val Val 
                245                 250                 255     


Ile Leu Met Ile Pro Ile Ala Val Cys Ile Tyr Trp Ile Asn Lys Leu 
            260                 265                 270         


Gln Lys Glu Lys Lys Ile Leu Ser Gly Glu Lys Glu Phe Glu Arg Glu 
        275                 280                 285             


Thr Arg Glu Ile Ala Leu Lys Glu Leu Glu Lys Glu Arg Val Gln Lys 
    290                 295                 300                 


Glu Glu Glu Leu Gln Val Lys Glu Lys Leu Gln Glu Glu Leu Arg Trp 
305                 310                 315                 320 


Arg Arg Thr Phe Leu His Ala Glu Leu Gln Phe Phe Ser Asn 
                325                 330                 


<210>  5592
<211>  835
<212>  PRT
<213>  Homo sapiens

<400>  5592

Met Gly Gly Arg Val Phe Leu Ala Phe Cys Val Trp Leu Thr Leu Pro 
1               5                   10                  15      


Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp Cys Pro Gln 
            20                  25                  30          


Asn Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn Pro Gly Phe 
        35                  40                  45              


Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Thr Glu Thr Cys Asp Asp 
    50                  55                  60                  


Ile Asn Glu Cys Ala Thr Pro Ser Lys Val Ser Cys Gly Lys Phe Ser 
65                  70                  75                  80  


Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly 
                85                  90                  95      


Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu Ser Glu Asn 
            100                 105                 110         


Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg Leu Cys Lys 
        115                 120                 125             


Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr Cys Gln Cys 
    130                 135                 140                 


Leu Pro Gly Phe Lys Phe Ile Pro Glu Asp Pro Lys Val Cys Thr Asp 
145                 150                 155                 160 


Val Asn Glu Cys Thr Ser Gly Gln Asn Pro Cys His Ser Ser Thr His 
                165                 170                 175     


Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg Pro Gly Trp 
            180                 185                 190         


Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Thr Val Cys Glu 
        195                 200                 205             


Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp Ser Ser Thr 
    210                 215                 220                 


Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys Arg Pro Gly 
225                 230                 235                 240 


Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp Thr Val Cys 
                245                 250                 255     


Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly Val His Ser 
            260                 265                 270         


Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu Gly Arg Asp 
        275                 280                 285             


Ser Lys Thr Ser Ser Ala Glu Val Thr Ile Gln Asn Val Ile Lys Leu 
    290                 295                 300                 


Val Asp Glu Leu Met Glu Ala Pro Gly Asp Val Glu Ala Leu Ala Pro 
305                 310                 315                 320 


Pro Val Arg His Leu Ile Ala Thr Gln Leu Leu Ser Asn Leu Glu Asp 
                325                 330                 335     


Ile Met Arg Ile Leu Ala Lys Ser Leu Pro Lys Gly Pro Phe Thr Tyr 
            340                 345                 350         


Ile Ser Pro Ser Asn Thr Glu Leu Thr Leu Met Ile Gln Glu Arg Gly 
        355                 360                 365             


Asp Lys Asn Val Thr Met Gly Gln Ser Ser Ala Arg Met Lys Leu Asn 
    370                 375                 380                 


Trp Ala Val Ala Ala Gly Ala Glu Asp Pro Gly Pro Ala Val Ala Gly 
385                 390                 395                 400 


Ile Leu Ser Ile Gln Asn Met Thr Thr Leu Leu Ala Asn Ala Ser Leu 
                405                 410                 415     


Asn Leu His Ser Lys Lys Gln Ala Glu Leu Glu Glu Ile Tyr Glu Ser 
            420                 425                 430         


Ser Ile Arg Gly Val Gln Leu Arg Arg Leu Ser Ala Val Asn Ser Ile 
        435                 440                 445             


Phe Leu Ser His Asn Asn Thr Lys Glu Leu Asn Ser Pro Ile Leu Phe 
    450                 455                 460                 


Ala Phe Ser His Leu Glu Ser Ser Asp Gly Glu Ala Gly Arg Asp Pro 
465                 470                 475                 480 


Pro Ala Lys Asp Val Met Pro Gly Pro Arg Gln Glu Leu Leu Cys Ala 
                485                 490                 495     


Phe Trp Lys Ser Asp Ser Asp Arg Gly Gly His Trp Ala Thr Glu Gly 
            500                 505                 510         


Cys Gln Val Leu Gly Ser Lys Asn Gly Ser Thr Thr Cys Gln Cys Ser 
        515                 520                 525             


His Leu Ser Ser Phe Ala Ile Leu Met Ala His Tyr Asp Val Glu Asp 
    530                 535                 540                 


Trp Lys Leu Thr Leu Ile Thr Arg Val Gly Leu Ala Leu Ser Leu Phe 
545                 550                 555                 560 


Cys Leu Leu Leu Cys Ile Leu Thr Phe Leu Leu Val Arg Pro Ile Gln 
                565                 570                 575     


Gly Ser Arg Thr Thr Ile His Leu His Leu Cys Ile Cys Leu Phe Val 
            580                 585                 590         


Gly Ser Thr Ile Phe Leu Ala Gly Ile Glu Asn Glu Gly Gly Gln Val 
        595                 600                 605             


Gly Leu Arg Cys Arg Leu Val Ala Gly Leu Leu His Tyr Cys Phe Leu 
    610                 615                 620                 


Ala Ala Phe Cys Trp Met Ser Leu Glu Gly Leu Glu Leu Tyr Phe Leu 
625                 630                 635                 640 


Val Val Arg Val Phe Gln Gly Gln Gly Leu Ser Thr Arg Trp Leu Cys 
                645                 650                 655     


Leu Ile Gly Tyr Gly Val Pro Leu Leu Ile Val Gly Val Ser Ala Ala 
            660                 665                 670         


Ile Tyr Ser Lys Gly Tyr Gly Arg Pro Arg Tyr Cys Trp Leu Asp Phe 
        675                 680                 685             


Glu Gln Gly Phe Leu Trp Ser Phe Leu Gly Pro Val Thr Phe Ile Ile 
    690                 695                 700                 


Leu Cys Asn Ala Val Ile Phe Val Thr Thr Val Trp Lys Leu Thr Gln 
705                 710                 715                 720 


Lys Phe Ser Glu Ile Asn Pro Asp Met Lys Lys Leu Lys Lys Ala Arg 
                725                 730                 735     


Ala Leu Thr Ile Thr Ala Ile Ala Gln Leu Phe Leu Leu Gly Cys Thr 
            740                 745                 750         


Trp Val Phe Gly Leu Phe Ile Phe Asp Asp Arg Ser Leu Val Leu Thr 
        755                 760                 765             


Tyr Val Phe Thr Ile Leu Asn Cys Leu Gln Gly Ala Phe Leu Tyr Leu 
    770                 775                 780                 


Leu His Cys Leu Leu Asn Lys Lys Val Arg Glu Glu Tyr Arg Lys Trp 
785                 790                 795                 800 


Ala Cys Leu Val Ala Gly Gly Ser Lys Tyr Ser Glu Phe Thr Ser Thr 
                805                 810                 815     


Thr Ser Gly Thr Gly His Asn Gln Thr Arg Ala Leu Arg Ala Ser Glu 
            820                 825                 830         


Ser Gly Ile 
        835 


<210>  5593
<211>  476
<212>  PRT
<213>  Homo sapiens

<400>  5593

Met Ser Thr Gln Arg Leu Arg Asn Glu Asp Tyr His Asp Tyr Ser Ser 
1               5                   10                  15      


Thr Asp Val Ser Pro Glu Glu Ser Pro Ser Glu Gly Leu Asn Asn Leu 
            20                  25                  30          


Ser Ser Pro Gly Ser Tyr Gln Arg Phe Gly Gln Ser Asn Ser Thr Thr 
        35                  40                  45              


Trp Phe Gln Thr Leu Ile His Leu Leu Lys Gly Asn Ile Gly Thr Gly 
    50                  55                  60                  


Leu Leu Gly Leu Pro Leu Ala Val Lys Asn Ala Gly Ile Val Met Gly 
65                  70                  75                  80  


Pro Ile Ser Leu Leu Ile Ile Gly Ile Val Ala Val His Cys Met Gly 
                85                  90                  95      


Ile Leu Val Lys Cys Ala His His Phe Cys Arg Arg Leu Asn Lys Ser 
            100                 105                 110         


Phe Val Asp Tyr Gly Asp Thr Val Met Tyr Gly Leu Glu Ser Ser Pro 
        115                 120                 125             


Cys Ser Trp Leu Arg Asn His Ala His Trp Gly Arg Arg Val Val Asp 
    130                 135                 140                 


Phe Phe Leu Ile Val Thr Gln Leu Gly Phe Cys Cys Val Tyr Phe Val 
145                 150                 155                 160 


Phe Leu Ala Asp Asn Phe Lys Gln Val Ile Glu Ala Ala Asn Gly Thr 
                165                 170                 175     


Thr Asn Asn Cys His Asn Asn Glu Thr Val Ile Leu Thr Pro Thr Met 
            180                 185                 190         


Asp Ser Arg Leu Tyr Met Leu Ser Phe Leu Pro Phe Leu Val Leu Leu 
        195                 200                 205             


Val Phe Ile Arg Asn Leu Arg Ala Leu Ser Ile Phe Ser Leu Leu Ala 
    210                 215                 220                 


Asn Ile Thr Met Leu Val Ser Leu Val Met Ile Tyr Gln Phe Ile Val 
225                 230                 235                 240 


Gln Arg Ile Pro Asp Pro Ser His Leu Pro Leu Val Ala Pro Trp Lys 
                245                 250                 255     


Thr Tyr Pro Leu Phe Phe Gly Thr Ala Ile Phe Ser Phe Glu Gly Ile 
            260                 265                 270         


Gly Met Val Leu Pro Leu Glu Asn Lys Met Lys Asp Pro Arg Lys Phe 
        275                 280                 285             


Pro Leu Ile Leu Tyr Leu Gly Met Val Ile Val Thr Ile Leu Tyr Ile 
    290                 295                 300                 


Ser Leu Gly Cys Leu Gly Tyr Leu Gln Phe Gly Ala Asn Ile Gln Gly 
305                 310                 315                 320 


Ser Ile Thr Leu Asn Leu Pro Asn Cys Trp Leu Tyr Gln Ser Val Lys 
                325                 330                 335     


Leu Leu Tyr Ser Ile Gly Ile Phe Phe Thr Tyr Ala Leu Gln Phe Tyr 
            340                 345                 350         


Val Pro Ala Glu Ile Ile Ile Pro Phe Phe Val Ser Arg Ala Pro Glu 
        355                 360                 365             


His Cys Glu Leu Val Val Asp Leu Phe Val Arg Thr Val Leu Val Cys 
    370                 375                 380                 


Leu Thr Cys Ile Leu Ala Ile Leu Ile Pro Arg Leu Asp Leu Val Ile 
385                 390                 395                 400 


Ser Leu Val Gly Ser Val Ser Ser Ser Ala Leu Ala Leu Ile Ile Pro 
                405                 410                 415     


Pro Leu Leu Glu Val Thr Thr Phe Tyr Ser Glu Gly Met Ser Pro Leu 
            420                 425                 430         


Thr Ile Phe Lys Asp Ala Leu Ile Ser Ile Leu Gly Phe Val Gly Phe 
        435                 440                 445             


Val Val Gly Thr Tyr Glu Ala Leu Tyr Glu Leu Ile Gln Pro Ser Asn 
    450                 455                 460                 


Ala Pro Ile Phe Ile Asn Ser Thr Cys Ala Phe Ile 
465                 470                 475     


<210>  5594
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  5594

Met Asn Glu Asn Ile Asp Ile Leu Glu Thr Ala Ile Lys Gln Ala Ala 
1               5                   10                  15      


Glu Gln Gly Ala Arg Ile Ile Val Thr Pro Glu Asp Ala Leu Tyr Gly 
            20                  25                  30          


Trp Lys Phe Thr Arg Glu Thr Val Phe Pro Tyr Leu Glu Asp Ile Pro 
        35                  40                  45              


Asp Pro Gln Val Asn Trp Ile Pro Cys Gln Asp Pro His Arg Phe Gly 
    50                  55                  60                  


His Thr Pro Val Gln Ala Arg Leu Ser Cys Leu Ala Lys Asp Asn Ser 
65                  70                  75                  80  


Ile Tyr Val Leu Ala Asn Leu Gly Asp Lys Lys Pro Cys Asn Ser Arg 
                85                  90                  95      


Asp Ser Thr Cys Pro Pro Asn Gly Tyr Phe Gln Tyr Asn Thr Asn Val 
            100                 105                 110         


Val Tyr Asn Thr Glu Gly Lys Leu Val Ala Arg Tyr His Lys Tyr His 
        115                 120                 125             


Leu Tyr Ser Glu Pro Gln Phe Asn Val Pro Glu Lys Pro Glu Leu Val 
    130                 135                 140                 


Thr Phe Asn Thr Ala Phe Gly Arg Phe Gly Ile Phe Thr Cys Phe Asp 
145                 150                 155                 160 


Ile Phe Phe Tyr Asp Pro Gly Val Thr Leu Val Lys Asp Phe His Val 
                165                 170                 175     


Asp Thr Ile Leu Phe Pro Thr Ala Trp Met Asn Val Leu Pro Leu Leu 
            180                 185                 190         


Thr Ala Ile Glu Phe His Ser Ala Trp Ala Met Gly Met Gly Val Asn 
        195                 200                 205             


Leu Leu Val Ala Asn Thr His His Val Ser Leu Asn Met Thr Gly Ser 
    210                 215                 220                 


Gly Ile Tyr Ala Pro Asn Gly Pro Lys Val Tyr His Tyr Asp Met Lys 
225                 230                 235                 240 


Thr Glu Leu Gly Lys Leu Leu Leu Ser Glu Val Asp Ser His Pro Leu 
                245                 250                 255     


Ser Ser Leu Ala Tyr Pro Thr Ala Val Asn Trp Asn Ala Tyr Ala Thr 
            260                 265                 270         


Thr Ile Lys Pro Phe Pro Val Gln Lys Asn Thr Phe Arg Gly Phe Ile 
        275                 280                 285             


Ser Arg Asp Gly Phe Asn Phe Thr Glu Leu Phe Glu Asn Ala Gly Asn 
    290                 295                 300                 


Leu Thr Val Cys Gln Lys Glu Leu Cys Cys His Leu Ser Tyr Arg Met 
305                 310                 315                 320 


Leu Gln Lys Glu Glu Asn Glu Val Tyr Val Leu Gly Ala Phe Thr Gly 
                325                 330                 335     


Leu His Gly Arg Arg Arg Arg Glu Tyr Trp Gln Val Cys Thr Met Leu 
            340                 345                 350         


Lys Cys Lys Thr Thr Asn Leu Thr Thr Cys Gly Arg Pro Val Glu Thr 
        355                 360                 365             


Ala Ser Thr Arg Phe Glu Met Phe Ser Leu Ser Gly Thr Phe Gly Thr 
    370                 375                 380                 


Glu Tyr Val Phe Pro Glu Val Leu Leu Thr Glu Ile His Leu Ser Pro 
385                 390                 395                 400 


Gly Lys Phe Glu Val Leu Lys Asp Gly Arg Leu Val Asn Lys Asn Gly 
                405                 410                 415     


Ser Ser Gly Pro Ile Leu Thr Val Ser Leu Phe Gly Arg Trp Tyr Thr 
            420                 425                 430         


Lys Asp Ser Leu Tyr Ser Ser Cys Gly Thr Ser Asn Ser Ala Ile Thr 
        435                 440                 445             


Tyr Leu Leu Ile Phe Ile Leu Leu Met Ile Ile Ala Leu Gln Asn Ile 
    450                 455                 460                 


Val Met Leu 
465         


<210>  5595
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  5595

Met Gly Val Asn Leu Leu Ala Ala Asn Thr His Asn Thr Ser Met His 
1               5                   10                  15      


Met Thr Gly Ser Gly Ile Tyr Ala Pro Glu Ala Val Lys Val Tyr His 
            20                  25                  30          


Tyr Asp Met Glu Thr Glu Ser Gly Gln Leu Leu Leu Ser Glu Leu Lys 
        35                  40                  45              


Ser Arg Pro Arg Arg Glu Pro Thr Tyr Pro Ala Ala Val Asp Trp His 
    50                  55                  60                  


Ala Tyr Ala Ser Ser Val Lys Pro Phe Ser Ser Glu Gln Ser Asp Phe 
65                  70                  75                  80  


Leu Gly Met Ile Tyr Phe Asp Glu Phe Thr Phe Thr Lys Leu Lys Arg 
                85                  90                  95      


Asn Thr Gly Asn Tyr Thr Ala Cys Gln Lys Asp Leu Cys Cys His Leu 
            100                 105                 110         


Thr Tyr Lys Met Ser Glu Lys Arg Thr Asp Glu Ile Tyr Ala Leu Gly 
        115                 120                 125             


Ala Phe Asp Gly Leu His Thr Val Glu Gly Gln Tyr Tyr Leu Gln Ile 
    130                 135                 140                 


Cys Ala Leu Leu Lys Cys Gln Thr Thr Asp Leu Glu Thr Cys Gly Glu 
145                 150                 155                 160 


Pro Val Gly Ser Ala Phe Thr Lys Phe Glu Asp Phe Ser Leu Ser Gly 
                165                 170                 175     


Thr Phe Gly Thr Arg Tyr Val Phe Pro Gln Ile Ile Leu Ser Gly Ser 
            180                 185                 190         


Gln Leu Ala Pro Glu Arg His Tyr Glu Ile Ser Arg Asp Gly Arg Leu 
        195                 200                 205             


Arg Ser Arg Ser Gly Ala Pro Leu Pro Val Leu Val Met Ala Leu Tyr 
    210                 215                 220                 


Gly Arg Val Phe Glu Lys Asp Pro Pro Arg Leu Gly Gln Gly Ser Gly 
225                 230                 235                 240 


Lys Phe Gln 
            


<210>  5596
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  5596

Met Ser Glu Lys Glu Asn Asn Phe Pro Pro Leu Pro Lys Phe Ile Pro 
1               5                   10                  15      


Val Lys Pro Cys Phe Tyr Gln Asn Phe Ser Asp Glu Ile Pro Val Glu 
            20                  25                  30          


His Gln Val Leu Val Lys Arg Ile Tyr Arg Leu Trp Met Phe Tyr Cys 
        35                  40                  45              


Ala Thr Leu Gly Val Asn Leu Ile Ala Cys Leu Ala Trp Trp Ile Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Asn Phe Gly Leu Ala Phe Val Trp Leu Leu Leu 
65                  70                  75                  80  


Phe Thr Pro Cys Gly Tyr Val Cys Trp Phe Arg Pro Val Tyr Lys Ala 
                85                  90                  95      


Phe Arg Ala Asp Ser Ser Phe Asn Phe Met Ala Phe Phe Phe Ile Phe 
            100                 105                 110         


Gly Ala Gln Phe Val Leu Thr Val Ile Gln Ala Ile Gly Phe Ser Gly 
        115                 120                 125             


Trp Gly Ala Cys Gly Trp Leu Ser Ala Ile Gly Phe Phe Gln Tyr Ser 
    130                 135                 140                 


Pro Gly Ala Ala Val Val Met Leu Leu Pro Ala Ile Met Phe Ser Val 
145                 150                 155                 160 


Ser Ala Ala Met Met Ala Ile Ala Ile Met Lys Val His Arg Ile Tyr 
                165                 170                 175     


Arg Gly Ala Gly Gly Ser Phe Gln Lys Ala Gln Thr Glu Trp Asn Thr 
            180                 185                 190         


Gly Thr Trp Arg Asn Pro Pro Ser Arg Glu Ala Gln Tyr Asn Asn Phe 
        195                 200                 205             


Ser Gly Asn Ser Leu Pro Glu Tyr Pro Thr Val Pro Ser Tyr Pro Gly 
    210                 215                 220                 


Ser Gly Gln Trp Pro 
225                 


<210>  5597
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  5597

Met Met Ser Glu His Asp Leu Ala Asp Val Val Gln Ile Ala Val Glu 
1               5                   10                  15      


Asp Leu Ser Pro Asp His Pro Val Val Leu Glu Asn His Val Val Thr 
            20                  25                  30          


Asp Glu Asp Glu Pro Ala Leu Lys Arg Gln Arg Leu Glu Ile Asn Cys 
        35                  40                  45              


Gln Asp Pro Ser Ile Lys Ser Phe Leu Tyr Ser Ile Asn Gln Thr Ile 
    50                  55                  60                  


Cys Leu Arg Leu Asp Ser Ile Glu Ala Lys Leu Gln Ala Leu Glu Ala 
65                  70                  75                  80  


Thr Cys Lys Ser Leu Glu Glu Lys Leu Asp Leu Val Thr Asn Lys Gln 
                85                  90                  95      


His Ser Pro Ile Gln Val Pro Met Val Ala Gly Ser Pro Leu Gly Ala 
            100                 105                 110         


Thr Gln Thr Cys Asn Lys Val Arg Cys Ala Val Pro Gly Arg Arg Gln 
        115                 120                 125             


Asn Thr Ile Val Val Lys Val Pro Gly Gln Glu Asp Ser His His Glu 
    130                 135                 140                 


Asp Gly Glu Ser Gly Ser Glu Ala Ser Asp Ser Val Ser Ser Cys Gly 
145                 150                 155                 160 


Gln Ala Gly Ser Gln Ser Ile Gly Ser Asn Val Thr Leu Ile Thr Leu 
                165                 170                 175     


Asn Ser Glu Glu Asp Tyr Pro Asn Gly Thr Trp Leu Gly Asp Glu Asn 
            180                 185                 190         


Asn Pro Glu Met Arg Val Arg Cys Ala Ile Ile Pro Ser Asp Met Leu 
        195                 200                 205             


His Ile Ser Thr Asn Cys Arg Thr Ala Glu Lys Met Ala Leu Thr Leu 
    210                 215                 220                 


Leu Asp Tyr Leu Phe His Arg Glu Val Gln Ala Val Ser Asn Leu Ser 
225                 230                 235                 240 


Gly Gln Gly Lys His Gly Lys Lys Gln Leu Asp Pro Leu Thr Ile Tyr 
                245                 250                 255     


Gly Ile Arg Cys His Leu Phe Tyr Lys Phe Gly Ile Thr Glu Ser Asp 
            260                 265                 270         


Trp Tyr Arg Ile Lys Gln Ser Ile Asp Ser Lys Cys Arg Thr Ala Trp 
        275                 280                 285             


Arg Arg Lys Gln Arg Gly Gln Ser Leu Ala Val Lys Ser Phe Ser Arg 
    290                 295                 300                 


Arg Thr Pro Asn Ser Ser Ser Tyr Cys Pro Ser Glu Pro Met Met Ser 
305                 310                 315                 320 


Thr Pro Pro Pro Ala Ser Glu Leu Pro Gln Pro Gln Pro Gln Pro Gln 
                325                 330                 335     


Ala Leu His Tyr Ala Leu Ala Asn Ala Gln Gln Val Gln Ile His Gln 
            340                 345                 350         


Ile Gly Glu Asp Gly Gln Val Gln Val Ile Pro Gln Gly His Leu His 
        355                 360                 365             


Ile Ala Gln Val Pro Gln Gly Glu Gln Val Gln Ile Thr Gln Asp Ser 
    370                 375                 380                 


Glu Gly Asn Leu Gln Ile His His Val Gly Gln Asp Gly Gln Leu Leu 
385                 390                 395                 400 


Glu Ala Thr Arg Ile Pro Cys Leu Leu Ala Pro Ser Val Phe Lys Ala 
                405                 410                 415     


Ser Ser Gly Gln Val Leu Gln Gly Ala Gln Leu Ile Ala Val Ala Ser 
            420                 425                 430         


Ser Asp Pro Ala Ala Ala Gly Val Asp Gly Ser Pro Leu Gln Gly Ser 
        435                 440                 445             


Asp Ile Gln Val Gln Tyr Val Gln Leu Ala Pro Val Ser Asp His Thr 
    450                 455                 460                 


Ala Gly Ala Gln Thr Ala Glu Ala Leu Gln Pro Thr Leu Gln Pro Glu 
465                 470                 475                 480 


Met Gln Leu Glu His Gly Ala Ile Gln Ile Gln 
                485                 490     


<210>  5598
<211>  1624
<212>  PRT
<213>  Homo sapiens

<400>  5598

Met Ser Lys Arg Arg Met Ser Val Gly Gln Gln Thr Trp Ala Leu Leu 
1               5                   10                  15      


Cys Lys Asn Cys Leu Lys Lys Trp Arg Met Lys Arg Gln Thr Leu Leu 
            20                  25                  30          


Glu Trp Leu Phe Ser Phe Leu Leu Val Leu Phe Leu Tyr Leu Phe Phe 
        35                  40                  45              


Ser Asn Leu His Gln Val His Asp Thr Pro Gln Met Ser Ser Met Asp 
    50                  55                  60                  


Leu Gly Arg Val Asp Ser Phe Asn Asp Thr Asn Tyr Val Ile Ala Phe 
65                  70                  75                  80  


Ala Pro Glu Ser Lys Thr Thr Gln Glu Ile Met Asn Lys Val Ala Ser 
                85                  90                  95      


Ala Pro Phe Leu Lys Gly Arg Thr Ile Met Gly Trp Pro Asp Glu Lys 
            100                 105                 110         


Ser Met Asp Glu Leu Asp Leu Asn Tyr Ser Ile Asp Ala Val Arg Val 
        115                 120                 125             


Ile Phe Thr Asp Thr Phe Ser Tyr His Leu Lys Phe Ser Trp Gly His 
    130                 135                 140                 


Arg Ile Pro Met Met Lys Glu His Arg Asp His Ser Ala His Cys Gln 
145                 150                 155                 160 


Ala Val Asn Glu Lys Met Lys Cys Glu Gly Ser Glu Phe Trp Glu Lys 
                165                 170                 175     


Gly Phe Val Ala Phe Gln Ala Ala Ile Asn Ala Ala Ile Ile Glu Ile 
            180                 185                 190         


Ala Thr Asn His Ser Val Met Glu Gln Leu Met Ser Val Thr Gly Val 
        195                 200                 205             


His Met Lys Ile Leu Pro Phe Val Ala Gln Gly Gly Val Ala Thr Asp 
    210                 215                 220                 


Phe Phe Ile Phe Phe Cys Ile Ile Ser Phe Ser Thr Phe Ile Tyr Tyr 
225                 230                 235                 240 


Val Ser Val Asn Val Thr Gln Glu Arg Gln Tyr Ile Thr Ser Leu Met 
                245                 250                 255     


Thr Met Met Gly Leu Arg Glu Ser Ala Phe Trp Leu Ser Trp Gly Leu 
            260                 265                 270         


Met Tyr Ala Gly Phe Ile Leu Ile Met Ala Thr Leu Met Ala Leu Ile 
        275                 280                 285             


Val Lys Ser Ala Gln Ile Val Val Leu Thr Gly Phe Val Met Val Phe 
    290                 295                 300                 


Thr Leu Phe Leu Leu Tyr Gly Leu Ser Leu Ile Thr Leu Ala Phe Leu 
305                 310                 315                 320 


Met Ser Val Leu Ile Lys Lys Pro Phe Leu Thr Gly Leu Val Val Phe 
                325                 330                 335     


Leu Leu Ile Val Phe Trp Gly Ile Leu Gly Phe Pro Ala Leu Tyr Thr 
            340                 345                 350         


Arg Leu Pro Ala Phe Leu Glu Trp Thr Leu Cys Leu Leu Ser Pro Phe 
        355                 360                 365             


Ala Phe Thr Val Gly Met Ala Gln Leu Ile His Leu Asp Tyr Asp Val 
    370                 375                 380                 


Asn Ser Asn Ala His Leu Asp Ser Ser Gln Asn Pro Tyr Leu Ile Ile 
385                 390                 395                 400 


Ala Thr Leu Phe Met Leu Val Phe Asp Thr Leu Leu Tyr Leu Val Leu 
                405                 410                 415     


Thr Leu Tyr Phe Asp Lys Ile Leu Pro Ala Glu Tyr Gly His Arg Cys 
            420                 425                 430         


Ser Pro Leu Phe Phe Leu Lys Ser Cys Phe Trp Phe Gln His Gly Arg 
        435                 440                 445             


Ala Asn His Val Val Leu Glu Asn Glu Thr Asp Ser Asp Pro Thr Pro 
    450                 455                 460                 


Asn Asp Cys Phe Glu Pro Val Ser Pro Glu Phe Cys Gly Lys Glu Ala 
465                 470                 475                 480 


Ile Arg Ile Lys Asn Leu Lys Lys Glu Tyr Ala Gly Lys Cys Glu Arg 
                485                 490                 495     


Val Glu Ala Leu Lys Gly Val Val Phe Asp Ile Tyr Glu Gly Gln Ile 
            500                 505                 510         


Thr Ala Leu Leu Gly His Ser Gly Ala Gly Lys Thr Thr Leu Leu Asn 
        515                 520                 525             


Ile Leu Ser Gly Leu Ser Val Pro Thr Ser Gly Ser Val Thr Val Tyr 
    530                 535                 540                 


Asn His Thr Leu Ser Arg Met Ala Asp Ile Glu Asn Ile Ser Lys Phe 
545                 550                 555                 560 


Thr Gly Phe Cys Pro Gln Ser Asn Val Gln Phe Gly Phe Leu Thr Val 
                565                 570                 575     


Lys Glu Asn Leu Arg Leu Phe Ala Lys Ile Lys Gly Ile Leu Pro His 
            580                 585                 590         


Glu Val Glu Lys Glu Val Gln Arg Val Val Gln Glu Leu Glu Met Glu 
        595                 600                 605             


Asn Ile Gln Asp Ile Leu Ala Gln Asn Leu Ser Gly Gly Gln Asn Arg 
    610                 615                 620                 


Lys Leu Thr Phe Gly Ile Ala Ile Leu Gly Asp Pro Gln Val Leu Leu 
625                 630                 635                 640 


Leu Asp Glu Pro Thr Ala Gly Leu Asp Pro Leu Ser Arg His Arg Ile 
                645                 650                 655     


Trp Asn Leu Leu Lys Glu Gly Lys Ser Asp Arg Val Ile Leu Phe Ser 
            660                 665                 670         


Thr Gln Phe Ile Asp Glu Ala Asp Ile Leu Ala Asp Arg Lys Val Phe 
        675                 680                 685             


Ile Ser Asn Gly Lys Leu Lys Cys Ala Gly Ser Ser Leu Phe Leu Lys 
    690                 695                 700                 


Lys Lys Trp Gly Ile Gly Tyr His Leu Ser Leu His Leu Asn Glu Arg 
705                 710                 715                 720 


Cys Asp Pro Glu Ser Ile Thr Ser Leu Val Lys Gln His Ile Ser Asp 
                725                 730                 735     


Ala Lys Leu Thr Ala Gln Ser Glu Glu Lys Leu Val Tyr Ile Leu Pro 
            740                 745                 750         


Leu Glu Arg Thr Asn Lys Phe Pro Glu Leu Tyr Arg Asp Leu Asp Arg 
        755                 760                 765             


Cys Ser Asn Gln Gly Ile Glu Asp Tyr Gly Val Ser Ile Thr Thr Leu 
    770                 775                 780                 


Asn Glu Val Phe Leu Lys Leu Glu Gly Lys Ser Thr Ile Asp Glu Ser 
785                 790                 795                 800 


Asp Ile Gly Ile Trp Gly Gln Leu Gln Thr Asp Gly Ala Lys Asp Ile 
                805                 810                 815     


Gly Ser Leu Val Glu Leu Glu Gln Val Leu Ser Ser Phe His Glu Thr 
            820                 825                 830         


Arg Lys Thr Ile Ser Gly Val Ala Leu Trp Arg Gln Gln Val Cys Ala 
        835                 840                 845             


Ile Ala Lys Val Arg Phe Leu Lys Leu Lys Lys Glu Arg Lys Ser Leu 
    850                 855                 860                 


Trp Thr Ile Leu Leu Leu Phe Gly Ile Ser Phe Ile Pro Gln Leu Leu 
865                 870                 875                 880 


Glu His Leu Phe Tyr Glu Ser Tyr Gln Lys Ser Tyr Pro Trp Glu Leu 
                885                 890                 895     


Ser Pro Asn Thr Tyr Phe Leu Ser Pro Gly Gln Gln Pro Gln Asp Pro 
            900                 905                 910         


Leu Thr His Leu Leu Val Ile Asn Lys Thr Gly Ser Thr Ile Asp Asn 
        915                 920                 925             


Phe Leu His Ser Leu Arg Arg Gln Asn Ile Ala Ile Glu Val Asp Ala 
    930                 935                 940                 


Phe Gly Thr Arg Asn Gly Thr Asp Asp Pro Ser Tyr Asn Gly Ala Ile 
945                 950                 955                 960 


Ile Val Ser Gly Asp Glu Lys Asp His Arg Phe Ser Ile Ala Cys Asn 
                965                 970                 975     


Thr Lys Arg Leu Asn Cys Phe Pro Val Leu Leu Asp Val Ile Ser Asn 
            980                 985                 990         


Gly Leu Leu Gly Ile Phe Asn Ser  Ser Glu His Ile Gln  Thr Asp Arg 
        995                 1000                 1005             


Ser Thr  Phe Phe Glu Glu His  Met Asp Tyr Glu Tyr  Gly Tyr Arg 
    1010                 1015                 1020             


Ser Asn  Thr Phe Phe Trp Ile  Pro Met Ala Ala Ser  Phe Thr Pro 
    1025                 1030                 1035             


Tyr Ile  Ala Met Ser Ser Ile  Gly Asp Tyr Lys Lys  Lys Ala His 
    1040                 1045                 1050             


Ser Gln  Leu Arg Ile Ser Gly  Leu Tyr Pro Ser Ala  Tyr Trp Phe 
    1055                 1060                 1065             


Gly Gln  Ala Leu Val Asp Val  Ser Leu Tyr Phe Leu  Ile Leu Leu 
    1070                 1075                 1080             


Leu Met  Gln Ile Met Asp Tyr  Ile Phe Ser Pro Glu  Glu Ile Ile 
    1085                 1090                 1095             


Phe Ile  Ile Gln Asn Leu Leu  Ile Gln Ile Leu Cys  Ser Ile Gly 
    1100                 1105                 1110             


Tyr Val  Ser Ser Leu Val Phe  Leu Thr Tyr Val Ile  Ser Phe Ile 
    1115                 1120                 1125             


Phe Arg  Asn Gly Arg Lys Asn  Ser Gly Ile Trp Ser  Phe Phe Phe 
    1130                 1135                 1140             


Leu Ile  Val Val Ile Phe Ser  Ile Val Ala Thr Asp  Leu Asn Glu 
    1145                 1150                 1155             


Tyr Gly  Phe Leu Gly Leu Phe  Phe Gly Thr Met Leu  Ile Pro Pro 
    1160                 1165                 1170             


Phe Thr  Leu Ile Gly Ser Leu  Phe Ile Phe Ser Glu  Ile Ser Pro 
    1175                 1180                 1185             


Asp Ser  Met Asp Tyr Leu Gly  Ala Ser Glu Ser Glu  Ile Val Tyr 
    1190                 1195                 1200             


Leu Ala  Leu Leu Ile Pro Tyr  Leu His Phe Leu Ile  Phe Leu Phe 
    1205                 1210                 1215             


Ile Leu  Arg Cys Leu Glu Met  Asn Cys Arg Lys Lys  Leu Met Arg 
    1220                 1225                 1230             


Lys Asp  Pro Val Phe Arg Ile  Ser Pro Arg Ser Asn  Ala Ile Phe 
    1235                 1240                 1245             


Pro Asn  Pro Glu Glu Pro Glu  Gly Glu Glu Glu Asp  Ile Gln Met 
    1250                 1255                 1260             


Glu Arg  Met Arg Thr Val Asn  Ala Met Ala Val Arg  Asp Phe Asp 
    1265                 1270                 1275             


Glu Thr  Pro Val Ile Ile Ala  Ser Cys Leu Arg Lys  Glu Tyr Ala 
    1280                 1285                 1290             


Gly Lys  Lys Lys Asn Cys Phe  Ser Lys Arg Lys Lys  Lys Ile Ala 
    1295                 1300                 1305             


Thr Arg  Asn Val Ser Phe Cys  Val Lys Lys Gly Glu  Val Ile Gly 
    1310                 1315                 1320             


Leu Leu  Gly His Asn Gly Ala  Gly Lys Ser Thr Thr  Ile Lys Met 
    1325                 1330                 1335             


Ile Thr  Gly Asp Thr Lys Pro  Thr Ala Gly Gln Val  Ile Leu Lys 
    1340                 1345                 1350             


Gly Ser  Gly Gly Gly Glu Pro  Leu Gly Phe Leu Gly  Tyr Cys Pro 
    1355                 1360                 1365             


Gln Glu  Asn Ala Leu Trp Pro  Asn Leu Thr Val Arg  Gln His Leu 
    1370                 1375                 1380             


Glu Val  Tyr Ala Ala Val Lys  Gly Leu Arg Lys Gly  Asp Ala Met 
    1385                 1390                 1395             


Ile Ala  Ile Thr Arg Leu Val  Asp Ala Leu Lys Leu  Gln Asp Gln 
    1400                 1405                 1410             


Leu Lys  Ala Pro Val Lys Thr  Leu Ser Glu Gly Ile  Lys Arg Lys 
    1415                 1420                 1425             


Leu Cys  Phe Val Leu Ser Ile  Leu Gly Asn Pro Ser  Val Val Leu 
    1430                 1435                 1440             


Leu Asp  Glu Pro Ser Thr Gly  Met Asp Pro Glu Gly  Gln Gln Gln 
    1445                 1450                 1455             


Met Trp  Gln Val Ile Arg Ala  Thr Phe Arg Asn Thr  Glu Arg Gly 
    1460                 1465                 1470             


Ala Leu  Leu Thr Thr His Tyr  Met Ala Glu Ala Glu  Ala Val Cys 
    1475                 1480                 1485             


Asp Arg  Val Ala Ile Met Val  Ser Gly Arg Leu Arg  Cys Ile Gly 
    1490                 1495                 1500             


Ser Ile  Gln His Leu Lys Ser  Lys Phe Gly Lys Asp  Tyr Leu Leu 
    1505                 1510                 1515             


Glu Met  Lys Leu Lys Asn Leu  Ala Gln Met Glu Pro  Leu His Ala 
    1520                 1525                 1530             


Glu Ile  Leu Arg Leu Phe Pro  Gln Ala Ala Gln Gln  Glu Arg Phe 
    1535                 1540                 1545             


Ser Ser  Leu Met Val Tyr Lys  Leu Pro Val Glu Asp  Val Arg Pro 
    1550                 1555                 1560             


Leu Ser  Gln Ala Phe Phe Lys  Leu Glu Ile Val Lys  Gln Ser Phe 
    1565                 1570                 1575             


Asp Leu  Glu Glu Tyr Ser Leu  Ser Gln Ser Thr Leu  Glu Gln Val 
    1580                 1585                 1590             


Phe Leu  Glu Leu Ser Lys Glu  Gln Glu Leu Gly Asp  Leu Glu Glu 
    1595                 1600                 1605             


Asp Phe  Asp Pro Ser Val Lys  Trp Lys Leu Leu Leu  Gln Glu Glu 
    1610                 1615                 1620             


Pro 
    


<210>  5599
<211>  1617
<212>  PRT
<213>  Homo sapiens

<400>  5599

Met Asn Met Lys Gln Lys Ser Val Tyr Gln Gln Thr Lys Ala Leu Leu 
1               5                   10                  15      


Cys Lys Asn Phe Leu Lys Lys Trp Arg Met Lys Arg Glu Ser Leu Leu 
            20                  25                  30          


Glu Trp Gly Leu Ser Ile Leu Leu Gly Leu Cys Ile Ala Leu Phe Ser 
        35                  40                  45              


Ser Ser Met Arg Asn Val Gln Phe Pro Gly Met Ala Pro Gln Asn Leu 
    50                  55                  60                  


Gly Arg Val Asp Lys Phe Asn Ser Ser Ser Leu Met Val Val Tyr Thr 
65                  70                  75                  80  


Pro Ile Ser Asn Leu Thr Gln Gln Ile Met Asn Lys Thr Ala Leu Ala 
                85                  90                  95      


Pro Leu Leu Lys Gly Thr Ser Val Ile Gly Ala Pro Asn Lys Thr His 
            100                 105                 110         


Met Asp Glu Ile Leu Leu Glu Asn Leu Pro Tyr Ala Met Gly Ile Ile 
        115                 120                 125             


Phe Asn Glu Thr Phe Ser Tyr Lys Leu Ile Phe Phe Gln Gly Tyr Asn 
    130                 135                 140                 


Ser Pro Leu Trp Lys Glu Asp Phe Ser Ala His Cys Trp Asp Gly Tyr 
145                 150                 155                 160 


Gly Glu Phe Ser Cys Thr Leu Thr Lys Tyr Trp Asn Arg Gly Phe Val 
                165                 170                 175     


Ala Leu Gln Thr Ala Ile Asn Thr Ala Ile Ile Glu Ile Thr Thr Asn 
            180                 185                 190         


His Pro Val Met Glu Glu Leu Met Ser Val Thr Ala Ile Thr Met Lys 
        195                 200                 205             


Thr Leu Pro Phe Ile Thr Lys Asn Leu Leu His Asn Glu Met Phe Ile 
    210                 215                 220                 


Leu Phe Phe Leu Leu His Phe Ser Pro Leu Val Tyr Phe Ile Ser Leu 
225                 230                 235                 240 


Asn Val Thr Lys Glu Arg Lys Lys Ser Lys Asn Leu Met Lys Met Met 
                245                 250                 255     


Gly Leu Gln Asp Ser Ala Phe Trp Leu Ser Trp Gly Leu Ile Tyr Ala 
            260                 265                 270         


Gly Phe Ile Phe Ile Ile Ser Ile Phe Val Thr Ile Ile Ile Thr Phe 
        275                 280                 285             


Thr Gln Ile Ile Val Met Thr Gly Phe Met Val Ile Phe Ile Leu Phe 
    290                 295                 300                 


Phe Leu Tyr Gly Leu Ser Leu Val Ala Leu Val Phe Leu Met Ser Val 
305                 310                 315                 320 


Leu Leu Lys Lys Ala Val Leu Thr Asn Leu Val Val Phe Leu Leu Thr 
                325                 330                 335     


Leu Phe Trp Gly Cys Leu Gly Phe Thr Val Phe Tyr Glu Gln Leu Pro 
            340                 345                 350         


Ser Ser Leu Glu Trp Ile Leu Asn Ile Cys Ser Pro Phe Ala Phe Thr 
        355                 360                 365             


Thr Gly Met Ile Gln Ile Ile Lys Leu Asp Tyr Asn Leu Asn Gly Val 
    370                 375                 380                 


Ile Phe Pro Asp Pro Ser Gly Asp Ser Tyr Thr Met Ile Ala Thr Phe 
385                 390                 395                 400 


Ser Met Leu Leu Leu Asp Gly Leu Ile Tyr Leu Leu Leu Ala Leu Tyr 
                405                 410                 415     


Phe Asp Lys Ile Leu Pro Tyr Gly Asp Glu Arg His Tyr Ser Pro Leu 
            420                 425                 430         


Phe Phe Leu Asn Ser Ser Ser Cys Phe Gln His Gln Arg Thr Asn Ala 
        435                 440                 445             


Lys Val Ile Glu Lys Glu Ile Asp Ala Glu His Pro Ser Asp Asp Tyr 
    450                 455                 460                 


Phe Glu Pro Val Ala Pro Glu Phe Gln Gly Lys Glu Ala Ile Arg Ile 
465                 470                 475                 480 


Arg Asn Val Lys Lys Glu Tyr Lys Gly Lys Ser Gly Lys Val Glu Ala 
                485                 490                 495     


Leu Lys Gly Leu Leu Phe Asp Ile Tyr Glu Gly Gln Ile Thr Ala Ile 
            500                 505                 510         


Leu Gly His Ser Gly Ala Gly Lys Ser Ser Leu Leu Asn Ile Leu Asn 
        515                 520                 525             


Gly Leu Ser Val Pro Thr Glu Gly Ser Val Thr Ile Tyr Asn Lys Asn 
    530                 535                 540                 


Leu Ser Glu Met Gln Asp Leu Glu Glu Ile Arg Lys Ile Thr Gly Val 
545                 550                 555                 560 


Cys Pro Gln Phe Asn Val Gln Phe Asp Ile Leu Thr Val Lys Glu Asn 
                565                 570                 575     


Leu Ser Leu Phe Ala Lys Ile Lys Gly Ile His Leu Lys Glu Val Glu 
            580                 585                 590         


Gln Glu Val Gln Arg Ile Leu Leu Glu Leu Asp Met Gln Asn Ile Gln 
        595                 600                 605             


Asp Asn Leu Ala Lys His Leu Ser Glu Gly Gln Lys Arg Lys Leu Thr 
    610                 615                 620                 


Phe Gly Ile Thr Ile Leu Gly Asp Pro Gln Ile Leu Leu Leu Asp Glu 
625                 630                 635                 640 


Pro Thr Thr Gly Leu Asp Pro Phe Ser Arg Asp Gln Val Trp Ser Leu 
                645                 650                 655     


Leu Arg Glu Arg Arg Ala Asp His Val Ile Leu Phe Ser Thr Gln Ser 
            660                 665                 670         


Met Asp Glu Ala Asp Ile Leu Ala Asp Arg Lys Val Ile Met Ser Asn 
        675                 680                 685             


Gly Arg Leu Lys Cys Ala Gly Ser Ser Met Phe Leu Lys Arg Arg Trp 
    690                 695                 700                 


Gly Leu Gly Tyr His Leu Ser Leu His Arg Asn Glu Ile Cys Asn Pro 
705                 710                 715                 720 


Glu Gln Ile Thr Ser Phe Ile Thr His His Ile Pro Asp Ala Lys Leu 
                725                 730                 735     


Lys Thr Glu Asn Lys Glu Lys Leu Val Tyr Thr Leu Pro Leu Glu Arg 
            740                 745                 750         


Thr Asn Thr Phe Pro Asp Leu Phe Ser Asp Leu Asp Lys Cys Ser Asp 
        755                 760                 765             


Gln Gly Val Thr Gly Tyr Asp Ile Ser Met Ser Thr Leu Asn Glu Val 
    770                 775                 780                 


Phe Met Lys Leu Glu Gly Gln Ser Thr Ile Glu Gln Asp Phe Glu Gln 
785                 790                 795                 800 


Val Glu Met Ile Arg Asp Ser Glu Ser Leu Asn Glu Met Glu Leu Ala 
                805                 810                 815     


His Ser Ser Phe Ser Glu Met Gln Thr Ala Val Ser Asp Met Gly Leu 
            820                 825                 830         


Trp Arg Met Gln Val Phe Ala Met Ala Arg Leu Arg Phe Leu Lys Leu 
        835                 840                 845             


Lys Arg Gln Thr Lys Val Leu Leu Thr Leu Leu Leu Val Phe Gly Ile 
    850                 855                 860                 


Ala Ile Phe Pro Leu Ile Val Glu Asn Ile Met Tyr Ala Met Leu Asn 
865                 870                 875                 880 


Glu Lys Ile Asp Trp Glu Phe Lys Asn Glu Leu Tyr Phe Leu Ser Pro 
                885                 890                 895     


Gly Gln Leu Pro Gln Glu Pro Arg Thr Ser Leu Leu Ile Ile Asn Asn 
            900                 905                 910         


Thr Glu Ser Asn Ile Glu Asp Phe Ile Lys Ser Leu Lys His Gln Asn 
        915                 920                 925             


Ile Leu Leu Glu Val Asp Asp Phe Glu Asn Arg Asn Gly Thr Asp Gly 
    930                 935                 940                 


Leu Ser Tyr Asn Gly Ala Ile Ile Val Ser Gly Lys Gln Lys Asp Tyr 
945                 950                 955                 960 


Arg Phe Ser Val Val Cys Asn Thr Lys Arg Leu His Cys Phe Pro Ile 
                965                 970                 975     


Leu Met Asn Ile Ile Ser Asn Gly Leu Leu Gln Met Phe Asn His Thr 
            980                 985                 990         


Gln His Ile Arg Ile Glu Ser Ser  Pro Phe Pro Leu Ser  His Ile Gly 
        995                 1000                 1005             


Leu Trp  Thr Gly Leu Pro Asp  Gly Ser Phe Phe Leu  Phe Leu Val 
    1010                 1015                 1020             


Leu Cys  Ser Ile Ser Pro Tyr  Ile Thr Met Gly Ser  Ile Ser Asp 
    1025                 1030                 1035             


Tyr Lys  Lys Asn Ala Lys Ser  Gln Leu Trp Ile Ser  Gly Leu Tyr 
    1040                 1045                 1050             


Thr Ser  Ala Tyr Trp Cys Gly  Gln Ala Leu Val Asp  Val Ser Phe 
    1055                 1060                 1065             


Phe Ile  Leu Ile Leu Leu Leu  Met Tyr Leu Ile Phe  Tyr Ile Glu 
    1070                 1075                 1080             


Asn Met  Gln Tyr Leu Leu Ile  Thr Ser Gln Ile Val  Phe Ala Leu 
    1085                 1090                 1095             


Val Ile  Val Thr Pro Gly Tyr  Ala Ala Ser Leu Val  Phe Phe Ile 
    1100                 1105                 1110             


Tyr Met  Ile Ser Phe Ile Phe  Arg Lys Arg Arg Lys  Asn Ser Gly 
    1115                 1120                 1125             


Leu Trp  Ser Phe Tyr Phe Phe  Phe Ala Ser Thr Ile  Met Phe Ser 
    1130                 1135                 1140             


Ile Thr  Leu Ile Asn His Phe  Asp Leu Ser Ile Leu  Ile Thr Thr 
    1145                 1150                 1155             


Met Val  Leu Val Pro Ser Tyr  Thr Leu Leu Gly Phe  Lys Thr Phe 
    1160                 1165                 1170             


Leu Glu  Val Arg Asp Gln Glu  His Tyr Arg Glu Phe  Pro Glu Ala 
    1175                 1180                 1185             


Asn Phe  Glu Leu Ser Ala Thr  Asp Phe Leu Val Cys  Phe Ile Pro 
    1190                 1195                 1200             


Tyr Phe  Gln Thr Leu Leu Phe  Val Phe Val Leu Arg  Cys Met Glu 
    1205                 1210                 1215             


Leu Lys  Cys Gly Lys Lys Arg  Met Arg Lys Asp Pro  Val Phe Arg 
    1220                 1225                 1230             


Ile Ser  Pro Gln Ser Arg Asp  Ala Lys Pro Asn Pro  Glu Glu Pro 
    1235                 1240                 1245             


Ile Asp  Glu Asp Glu Asp Ile  Gln Thr Glu Arg Ile  Arg Thr Ala 
    1250                 1255                 1260             


Thr Ala  Leu Thr Thr Ser Ile  Leu Asp Glu Lys Pro  Val Ile Ile 
    1265                 1270                 1275             


Ala Ser  Cys Leu His Lys Glu  Tyr Ala Gly Gln Lys  Lys Ser Cys 
    1280                 1285                 1290             


Phe Ser  Lys Arg Lys Lys Lys  Ile Ala Ala Arg Asn  Ile Ser Phe 
    1295                 1300                 1305             


Cys Val  Gln Glu Gly Glu Ile  Leu Gly Leu Leu Gly  Pro Asn Gly 
    1310                 1315                 1320             


Ala Gly  Lys Ser Ser Ser Ile  Arg Met Ile Ser Gly  Ile Thr Lys 
    1325                 1330                 1335             


Pro Thr  Ala Gly Glu Val Glu  Leu Lys Gly Cys Ser  Ser Val Leu 
    1340                 1345                 1350             


Gly His  Leu Gly Tyr Cys Pro  Gln Glu Asn Val Leu  Trp Pro Met 
    1355                 1360                 1365             


Leu Thr  Leu Arg Glu His Leu  Glu Val Tyr Ala Ala  Val Lys Gly 
    1370                 1375                 1380             


Leu Arg  Lys Ala Asp Ala Arg  Leu Ala Ile Ala Arg  Leu Val Ser 
    1385                 1390                 1395             


Ala Phe  Lys Leu His Glu Gln  Leu Asn Val Pro Val  Gln Lys Leu 
    1400                 1405                 1410             


Thr Ala  Gly Ile Thr Arg Lys  Leu Cys Phe Val Leu  Ser Leu Leu 
    1415                 1420                 1425             


Gly Asn  Ser Pro Val Leu Leu  Leu Asp Glu Pro Ser  Thr Gly Ile 
    1430                 1435                 1440             


Asp Pro  Thr Gly Gln Gln Gln  Met Trp Gln Ala Ile  Gln Ala Val 
    1445                 1450                 1455             


Val Lys  Asn Thr Glu Arg Gly  Val Leu Leu Thr Thr  His Asn Leu 
    1460                 1465                 1470             


Ala Glu  Ala Glu Ala Leu Cys  Asp Arg Val Ala Ile  Met Val Ser 
    1475                 1480                 1485             


Gly Arg  Leu Arg Cys Ile Gly  Ser Ile Gln His Leu  Lys Asn Lys 
    1490                 1495                 1500             


Leu Gly  Lys Asp Tyr Ile Leu  Glu Leu Lys Val Lys  Glu Thr Ser 
    1505                 1510                 1515             


Gln Val  Thr Leu Val His Thr  Glu Ile Leu Lys Leu  Phe Pro Gln 
    1520                 1525                 1530             


Ala Ala  Gly Gln Glu Arg Tyr  Ser Ser Leu Leu Thr  Tyr Lys Leu 
    1535                 1540                 1545             


Pro Val  Ala Asp Val Tyr Pro  Leu Ser Gln Thr Phe  His Lys Leu 
    1550                 1555                 1560             


Glu Ala  Val Lys His Asn Phe  Asn Leu Glu Glu Tyr  Ser Leu Ser 
    1565                 1570                 1575             


Gln Cys  Thr Leu Glu Lys Val  Phe Leu Glu Leu Ser  Lys Glu Gln 
    1580                 1585                 1590             


Glu Val  Gly Asn Phe Asp Glu  Glu Ile Asp Thr Thr  Met Arg Trp 
    1595                 1600                 1605             


Lys Leu  Leu Pro His Ser Asp  Glu Pro 
    1610                 1615         


<210>  5600
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  5600

Met Gly Leu Glu Lys Pro Gln Ser Lys Leu Glu Gly Gly Met His Pro 
1               5                   10                  15      


Gln Leu Ile Pro Ser Val Ile Ala Val Val Phe Ile Leu Leu Leu Ser 
            20                  25                  30          


Val Cys Phe Ile Ala Ser Cys Leu Val Thr His His Asn Phe Ser Arg 
        35                  40                  45              


Cys Lys Arg Gly Thr Gly Val His Lys Leu Glu His His Ala Lys Leu 
    50                  55                  60                  


Lys Cys Ile Lys Glu Lys Ser Glu Leu Lys Ser Ala Glu Gly Ser Thr 
65                  70                  75                  80  


Trp Asn Cys Cys Pro Ile Asp Trp Arg Ala Phe Gln Ser Asn Cys Tyr 
                85                  90                  95      


Phe Pro Leu Thr Asp Asn Lys Thr Trp Ala Glu Ser Glu Arg Asn Cys 
            100                 105                 110         


Ser Gly Met Gly Ala His Leu Met Thr Ile Ser Thr Glu Ala Glu Gln 
        115                 120                 125             


Asn Phe Ile Ile Gln Phe Leu Asp Arg Arg Leu Ser Tyr Phe Leu Gly 
    130                 135                 140                 


Leu Arg Asp Glu Asn Ala Lys Gly Gln Trp Arg Trp Val Asp Gln Thr 
145                 150                 155                 160 


Pro Phe Asn Pro Arg Arg Val Phe Trp His Lys Asn Glu Pro Asp Asn 
                165                 170                 175     


Ser Gln Gly Glu Asn Cys Val Val Leu Val Tyr Asn Gln Asp Lys Trp 
            180                 185                 190         


Ala Trp Asn Asp Val Pro Cys Asn Phe Glu Ala Ser Arg Ile Cys Lys 
        195                 200                 205             


Ile Pro Gly Thr Thr Leu Asn 
    210                 215 


<210>  5601
<211>  387
<212>  PRT
<213>  Homo sapiens

<400>  5601

Met Pro Thr Thr Ile Glu Arg Glu Phe Glu Glu Leu Asp Thr Gln Arg 
1               5                   10                  15      


Arg Trp Gln Pro Leu Tyr Leu Glu Ile Arg Asn Glu Ser His Asp Tyr 
            20                  25                  30          


Pro His Arg Val Ala Lys Phe Pro Glu Asn Arg Asn Arg Asn Arg Tyr 
        35                  40                  45              


Arg Asp Val Ser Pro Tyr Asp His Ser Arg Val Lys Leu Gln Asn Ala 
    50                  55                  60                  


Glu Asn Asp Tyr Ile Asn Ala Ser Leu Val Asp Ile Glu Glu Ala Gln 
65                  70                  75                  80  


Arg Ser Tyr Ile Leu Thr Gln Gly Pro Leu Pro Asn Thr Cys Cys His 
                85                  90                  95      


Phe Trp Leu Met Val Trp Gln Gln Lys Thr Lys Ala Val Val Met Leu 
            100                 105                 110         


Asn Arg Ile Val Glu Lys Glu Ser Val Lys Cys Ala Gln Tyr Trp Pro 
        115                 120                 125             


Thr Asp Asp Gln Glu Met Leu Phe Lys Glu Thr Gly Phe Ser Val Lys 
    130                 135                 140                 


Leu Leu Ser Glu Asp Val Lys Ser Tyr Tyr Thr Val His Leu Leu Gln 
145                 150                 155                 160 


Leu Glu Asn Ile Asn Ser Gly Glu Thr Arg Thr Ile Ser His Phe His 
                165                 170                 175     


Tyr Thr Thr Trp Pro Asp Phe Gly Val Pro Glu Ser Pro Ala Ser Phe 
            180                 185                 190         


Leu Asn Phe Leu Phe Lys Val Arg Glu Ser Gly Ser Leu Asn Pro Asp 
        195                 200                 205             


His Gly Pro Ala Val Ile His Cys Ser Ala Gly Ile Gly Arg Ser Gly 
    210                 215                 220                 


Thr Phe Ser Leu Val Asp Thr Cys Leu Val Leu Met Glu Lys Gly Asp 
225                 230                 235                 240 


Asp Ile Asn Ile Lys Gln Val Leu Leu Asn Met Arg Lys Tyr Arg Met 
                245                 250                 255     


Gly Leu Ile Gln Thr Pro Asp Gln Leu Arg Phe Ser Tyr Met Ala Ile 
            260                 265                 270         


Ile Glu Gly Ala Lys Cys Ile Lys Gly Asp Ser Ser Ile Gln Lys Arg 
        275                 280                 285             


Trp Lys Glu Leu Ser Lys Glu Asp Leu Ser Pro Ala Phe Asp His Ser 
    290                 295                 300                 


Pro Asn Lys Ile Met Thr Glu Lys Tyr Asn Gly Asn Arg Ile Gly Leu 
305                 310                 315                 320 


Glu Glu Glu Lys Leu Thr Gly Asp Arg Cys Thr Gly Leu Ser Ser Lys 
                325                 330                 335     


Met Gln Asp Thr Met Glu Glu Asn Ser Glu Ser Ala Leu Arg Lys Arg 
            340                 345                 350         


Ile Arg Glu Asp Arg Lys Ala Thr Thr Ala Gln Lys Val Gln Gln Met 
        355                 360                 365             


Lys Gln Arg Leu Asn Glu Asn Glu Arg Lys Arg Lys Arg Pro Arg Leu 
    370                 375                 380                 


Thr Asp Thr 
385         


<210>  5602
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  5602

Met Pro Thr Thr Ile Glu Arg Glu Phe Glu Glu Leu Asp Thr Gln Arg 
1               5                   10                  15      


Arg Trp Gln Pro Leu Tyr Leu Glu Ile Arg Asn Glu Ser His Asp Tyr 
            20                  25                  30          


Pro His Arg Val Ala Lys Phe Pro Glu Asn Arg Asn Arg Asn Arg Tyr 
        35                  40                  45              


Arg Asp Val Ser Pro Tyr Asp His Ser Arg Val Lys Leu Gln Asn Ala 
    50                  55                  60                  


Glu Asn Asp Tyr Ile Asn Ala Ser Leu Val Asp Ile Glu Glu Ala Gln 
65                  70                  75                  80  


Arg Ser Tyr Ile Leu Thr Gln Gly Pro Leu Pro Asn Thr Cys Cys His 
                85                  90                  95      


Phe Trp Leu Met Val Trp Gln Gln Lys Thr Lys Ala Val Val Met Leu 
            100                 105                 110         


Asn Arg Ile Val Glu Lys Glu Ser Val Lys Cys Ala Gln Tyr Trp Pro 
        115                 120                 125             


Thr Asp Asp Gln Glu Met Leu Phe Lys Glu Thr Gly Phe Ser Val Lys 
    130                 135                 140                 


Leu Leu Ser Glu Asp Val Lys Ser Tyr Tyr Thr Val His Leu Leu Gln 
145                 150                 155                 160 


Leu Glu Asn Ile Asn Ser Gly Glu Thr Arg Thr Ile Ser His Phe His 
                165                 170                 175     


Tyr Thr Thr Trp Pro Asp Phe Gly Val Pro Glu Ser Pro Ala Ser Phe 
            180                 185                 190         


Leu Asn Phe Leu Phe Lys Val Arg Glu Ser Gly Ser Leu Asn Pro Asp 
        195                 200                 205             


His Gly Pro Ala Val Ile His Cys Ser Ala Gly Ile Gly Arg Ser Gly 
    210                 215                 220                 


Thr Phe Ser Leu Val Asp Thr Cys Leu Val Leu Met Glu Lys Gly Asp 
225                 230                 235                 240 


Asp Ile Asn Ile Lys Gln Val Leu Leu Asn Met Arg Lys Tyr Arg Met 
                245                 250                 255     


Gly Leu Ile Gln Thr Pro Asp Gln Leu Arg Phe Ser Tyr Met Ala Ile 
            260                 265                 270         


Ile Glu Gly Ala Lys Cys Ile Lys Gly Asp Ser Ser Ile Gln Lys Arg 
        275                 280                 285             


Trp Lys Glu Leu Ser Lys Glu Asp Leu Ser Pro Ala Phe Asp His Ser 
    290                 295                 300                 


Pro Asn Lys Ile Met Thr Glu Lys Tyr Asn Gly Asn Arg Ile Gly Leu 
305                 310                 315                 320 


Glu Glu Glu Lys Leu Thr Gly Asp Arg Cys Thr Gly Leu Ser Ser Lys 
                325                 330                 335     


Met Gln Asp Thr Met Glu Glu Asn Ser Glu Arg Pro Arg Leu Thr Asp 
            340                 345                 350         


Thr 
    


<210>  5603
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  5603

Met Ser Leu Leu Leu Pro Pro Leu Ala Leu Leu Leu Leu Leu Ala Ala 
1               5                   10                  15      


Leu Val Ala Pro Ala Thr Ala Ala Thr Ala Tyr Arg Pro Asp Trp Asn 
            20                  25                  30          


Arg Leu Ser Gly Leu Thr Arg Ala Arg Val Glu Thr Cys Gly Gly Gln 
        35                  40                  45              


Leu Asn Arg Leu Lys Glu Val Lys Ala Phe Val Thr Gln Asp Ile Pro 
    50                  55                  60                  


Phe Tyr His Asn Leu Val Met Lys His Leu Pro Gly Ala Asp Pro Glu 
65                  70                  75                  80  


Leu Val Leu Leu Gly Arg Arg Tyr Glu Glu Leu Glu Arg Ile Pro Leu 
                85                  90                  95      


Ser Glu Met Thr Arg Glu Glu Ile Asn Ala Leu Val Gln Glu Leu Gly 
            100                 105                 110         


Phe Tyr Arg Lys Ala Ala Pro Asp Ala Gln Val Pro Pro Glu Tyr Val 
        115                 120                 125             


Trp Ala Pro Ala Lys Pro Pro Glu Glu Thr Ser Asp His Ala Asp Leu 
    130                 135                 140                 


<210>  5604
<211>  435
<212>  PRT
<213>  Homo sapiens

<400>  5604

Met Ala Ala Pro Leu Val Leu Val Leu Val Val Ala Val Thr Val Arg 
1               5                   10                  15      


Ala Ala Leu Phe Arg Ser Ser Leu Ala Glu Phe Ile Ser Glu Arg Val 
            20                  25                  30          


Glu Val Val Ser Pro Leu Ser Ser Trp Lys Arg Val Val Glu Gly Leu 
        35                  40                  45              


Ser Leu Leu Asp Leu Gly Val Ser Pro Tyr Ser Gly Ala Val Phe His 
    50                  55                  60                  


Glu Thr Pro Leu Ile Ile Tyr Leu Phe His Phe Leu Ile Asp Tyr Ala 
65                  70                  75                  80  


Glu Leu Val Phe Met Ile Thr Asp Ala Leu Thr Ala Ile Ala Leu Tyr 
                85                  90                  95      


Phe Ala Ile Gln Asp Phe Asn Lys Val Val Phe Lys Lys Gln Lys Leu 
            100                 105                 110         


Leu Leu Glu Leu Asp Gln Tyr Ala Pro Asp Val Ala Glu Leu Ile Arg 
        115                 120                 125             


Thr Pro Met Glu Met Arg Tyr Ile Pro Leu Lys Val Ala Leu Phe Tyr 
    130                 135                 140                 


Leu Leu Asn Pro Tyr Thr Ile Leu Ser Cys Val Ala Lys Ser Thr Cys 
145                 150                 155                 160 


Ala Ile Asn Asn Thr Leu Ile Ala Phe Phe Ile Leu Thr Thr Ile Lys 
                165                 170                 175     


Gly Ser Ala Phe Leu Ser Ala Ile Phe Leu Ala Leu Ala Thr Tyr Gln 
            180                 185                 190         


Ser Leu Tyr Pro Leu Thr Leu Phe Val Pro Gly Leu Leu Tyr Leu Leu 
        195                 200                 205             


Gln Arg Gln Tyr Ile Pro Val Lys Met Lys Ser Lys Ala Phe Trp Ile 
    210                 215                 220                 


Phe Ser Trp Glu Tyr Ala Met Met Tyr Val Gly Ser Leu Val Val Ile 
225                 230                 235                 240 


Ile Cys Leu Ser Phe Phe Leu Leu Ser Ser Trp Asp Phe Ile Pro Ala 
                245                 250                 255     


Val Tyr Gly Phe Ile Leu Ser Val Pro Asp Leu Thr Pro Asn Ile Gly 
            260                 265                 270         


Leu Phe Trp Tyr Phe Phe Ala Glu Met Phe Glu His Phe Ser Leu Phe 
        275                 280                 285             


Phe Val Cys Val Phe Gln Ile Asn Val Phe Phe Tyr Thr Ile Pro Leu 
    290                 295                 300                 


Ala Ile Lys Leu Lys Glu His Pro Ile Phe Phe Met Phe Ile Gln Ile 
305                 310                 315                 320 


Ala Val Ile Ala Ile Phe Lys Ser Tyr Pro Thr Val Gly Asp Val Ala 
                325                 330                 335     


Leu Tyr Met Ala Phe Phe Pro Val Trp Asn His Leu Tyr Arg Phe Leu 
            340                 345                 350         


Arg Asn Ile Phe Val Leu Thr Cys Ile Ile Ile Val Cys Ser Leu Leu 
        355                 360                 365             


Phe Pro Val Leu Trp His Leu Trp Ile Tyr Ala Gly Ser Ala Asn Ser 
    370                 375                 380                 


Asn Phe Phe Tyr Ala Ile Thr Leu Thr Phe Asn Val Gly Gln Ile Leu 
385                 390                 395                 400 


Leu Ile Ser Asp Tyr Phe Tyr Ala Phe Leu Arg Arg Glu Tyr Tyr Leu 
                405                 410                 415     


Thr His Gly Leu Tyr Leu Thr Ala Lys Asp Gly Thr Glu Ala Met Leu 
            420                 425                 430         


Val Leu Lys 
        435 


<210>  5605
<211>  657
<212>  PRT
<213>  Homo sapiens

<400>  5605

Met Gly Cys Cys Ser Ser Ala Ser Ser Ala Ala Gln Ser Ser Lys Arg 
1               5                   10                  15      


Glu Trp Lys Pro Leu Glu Asp Arg Ser Cys Thr Asp Ile Pro Trp Leu 
            20                  25                  30          


Leu Leu Phe Ile Leu Phe Cys Ile Gly Met Gly Phe Ile Cys Gly Phe 
        35                  40                  45              


Ser Ile Ala Thr Gly Ala Ala Ala Arg Leu Val Ser Gly Tyr Asp Ser 
    50                  55                  60                  


Tyr Gly Asn Ile Cys Gly Gln Lys Asn Thr Lys Leu Glu Ala Ile Pro 
65                  70                  75                  80  


Asn Ser Gly Met Asp His Thr Gln Arg Lys Tyr Val Phe Phe Leu Asp 
                85                  90                  95      


Pro Cys Asn Leu Asp Leu Ile Asn Arg Lys Ile Lys Ser Val Ala Leu 
            100                 105                 110         


Cys Val Ala Ala Cys Pro Arg Gln Glu Leu Lys Thr Leu Ser Asp Val 
        115                 120                 125             


Gln Lys Phe Ala Glu Ile Asn Gly Ser Ala Leu Cys Ser Tyr Asn Leu 
    130                 135                 140                 


Lys Pro Ser Glu Tyr Thr Thr Ser Pro Lys Ser Ser Val Leu Cys Pro 
145                 150                 155                 160 


Lys Leu Pro Val Pro Ala Ser Ala Pro Ile Pro Phe Phe His Arg Cys 
                165                 170                 175     


Ala Pro Val Asn Ile Ser Cys Tyr Ala Lys Phe Ala Glu Ala Leu Ile 
            180                 185                 190         


Thr Phe Val Ser Asp Asn Ser Val Leu His Arg Leu Ile Ser Gly Val 
        195                 200                 205             


Met Thr Ser Lys Glu Ile Ile Leu Gly Leu Cys Leu Leu Ser Leu Val 
    210                 215                 220                 


Leu Ser Met Ile Leu Met Val Ile Ile Arg Tyr Ile Ser Arg Val Leu 
225                 230                 235                 240 


Val Trp Ile Leu Thr Ile Leu Val Ile Leu Gly Ser Leu Gly Gly Thr 
                245                 250                 255     


Gly Val Leu Trp Trp Leu Tyr Ala Lys Gln Arg Arg Ser Pro Lys Glu 
            260                 265                 270         


Thr Val Thr Pro Glu Gln Leu Gln Ile Ala Glu Asp Asn Leu Arg Ala 
        275                 280                 285             


Leu Leu Ile Tyr Ala Ile Ser Ala Thr Val Phe Thr Val Ile Leu Phe 
    290                 295                 300                 


Leu Ile Met Leu Val Met Arg Lys Arg Val Ala Leu Thr Ile Ala Leu 
305                 310                 315                 320 


Phe His Val Ala Gly Lys Val Phe Ile His Leu Pro Leu Leu Val Phe 
                325                 330                 335     


Gln Pro Phe Trp Thr Phe Phe Ala Leu Val Leu Phe Trp Val Tyr Trp 
            340                 345                 350         


Ile Met Thr Leu Leu Phe Leu Gly Thr Thr Gly Ser Pro Val Gln Asn 
        355                 360                 365             


Glu Gln Gly Phe Val Glu Phe Lys Ile Ser Gly Pro Leu Gln Tyr Met 
    370                 375                 380                 


Trp Trp Tyr His Val Val Gly Leu Ile Trp Ile Ser Glu Phe Ile Leu 
385                 390                 395                 400 


Ala Cys Gln Gln Met Thr Val Ala Gly Ala Val Val Thr Tyr Tyr Phe 
                405                 410                 415     


Thr Arg Asp Lys Arg Asn Leu Pro Phe Thr Pro Ile Leu Ala Ser Val 
            420                 425                 430         


Asn Arg Leu Ile Arg Tyr His Leu Gly Thr Val Ala Lys Gly Ser Phe 
        435                 440                 445             


Ile Ile Thr Leu Val Lys Ile Pro Arg Met Ile Leu Met Tyr Ile His 
    450                 455                 460                 


Ser Gln Leu Lys Gly Lys Glu Asn Ala Cys Ala Arg Cys Val Leu Lys 
465                 470                 475                 480 


Ser Cys Ile Cys Cys Leu Trp Cys Leu Glu Lys Cys Leu Asn Tyr Leu 
                485                 490                 495     


Asn Gln Asn Ala Tyr Thr Ala Thr Ala Ile Asn Ser Thr Asn Phe Cys 
            500                 505                 510         


Thr Ser Ala Lys Asp Ala Phe Val Ile Leu Val Glu Asn Ala Leu Arg 
        515                 520                 525             


Val Ala Thr Ile Asn Thr Val Gly Asp Phe Met Leu Phe Leu Gly Lys 
    530                 535                 540                 


Val Leu Ile Val Cys Ser Thr Gly Leu Ala Gly Ile Met Leu Leu Asn 
545                 550                 555                 560 


Tyr Gln Gln Asp Tyr Thr Val Trp Val Leu Pro Leu Ile Ile Val Cys 
                565                 570                 575     


Leu Phe Ala Phe Leu Val Ala His Cys Phe Leu Ser Ile Tyr Glu Met 
            580                 585                 590         


Val Val Asp Val Leu Phe Leu Cys Phe Ala Ile Asp Thr Lys Tyr Asn 
        595                 600                 605             


Asp Gly Ser Pro Gly Arg Glu Phe Tyr Met Asp Lys Val Leu Met Glu 
    610                 615                 620                 


Phe Val Glu Asn Ser Arg Lys Ala Met Lys Glu Ala Gly Lys Gly Gly 
625                 630                 635                 640 


Val Ala Asp Ser Arg Glu Leu Lys Pro Met Ala Ser Gly Ala Ser Ser 
                645                 650                 655     


Ala 
    


<210>  5606
<211>  525
<212>  PRT
<213>  Homo sapiens

<400>  5606

Met Ala Thr Leu Leu Arg Ser Lys Leu Ser Asn Val Ala Thr Ser Val 
1               5                   10                  15      


Ser Asn Lys Ser Gln Ala Lys Met Ser Gly Met Phe Ala Arg Met Gly 
            20                  25                  30          


Phe Gln Ala Ala Thr Asp Glu Glu Ala Val Gly Phe Ala His Cys Asp 
        35                  40                  45              


Asp Leu Asp Phe Glu His Arg Gln Gly Leu Gln Met Asp Ile Leu Lys 
    50                  55                  60                  


Ala Glu Gly Glu Pro Cys Gly Asp Glu Gly Ala Glu Ala Pro Val Glu 
65                  70                  75                  80  


Gly Asp Ile His Tyr Gln Arg Gly Ser Gly Ala Pro Leu Pro Pro Ser 
                85                  90                  95      


Gly Ser Lys Asp Gln Val Gly Gly Gly Gly Glu Phe Gly Gly His Asp 
            100                 105                 110         


Lys Pro Lys Ile Thr Ala Trp Glu Ala Gly Trp Asn Val Thr Asn Ala 
        115                 120                 125             


Ile Gln Gly Met Phe Val Leu Gly Leu Pro Tyr Ala Ile Leu His Gly 
    130                 135                 140                 


Gly Tyr Leu Gly Leu Phe Leu Ile Ile Phe Ala Ala Val Val Cys Cys 
145                 150                 155                 160 


Tyr Thr Gly Lys Ile Leu Ile Ala Cys Leu Tyr Glu Glu Asn Glu Asp 
                165                 170                 175     


Gly Glu Val Val Arg Val Arg Asp Ser Tyr Val Ala Ile Ala Asn Ala 
            180                 185                 190         


Cys Cys Ala Pro Arg Phe Pro Thr Leu Gly Gly Arg Val Val Asn Val 
        195                 200                 205             


Ala Gln Ile Ile Glu Leu Val Met Thr Cys Ile Leu Tyr Val Val Val 
    210                 215                 220                 


Ser Gly Asn Leu Met Tyr Asn Ser Phe Pro Gly Leu Pro Val Ser Gln 
225                 230                 235                 240 


Lys Ser Trp Ser Ile Ile Ala Thr Ala Val Leu Leu Pro Cys Ala Phe 
                245                 250                 255     


Leu Lys Asn Leu Lys Ala Val Ser Lys Phe Ser Leu Leu Cys Thr Leu 
            260                 265                 270         


Ala His Phe Val Ile Asn Ile Leu Val Ile Ala Tyr Cys Leu Ser Arg 
        275                 280                 285             


Ala Arg Asp Trp Ala Trp Glu Lys Val Lys Phe Tyr Ile Asp Val Lys 
    290                 295                 300                 


Lys Phe Pro Ile Ser Ile Gly Ile Ile Val Phe Ser Tyr Thr Ser Gln 
305                 310                 315                 320 


Ile Phe Leu Pro Ser Leu Glu Gly Asn Met Gln Gln Pro Ser Glu Phe 
                325                 330                 335     


His Cys Met Met Asn Trp Thr His Ile Ala Ala Cys Val Leu Lys Gly 
            340                 345                 350         


Leu Phe Ala Leu Val Ala Tyr Leu Thr Trp Ala Asp Glu Thr Lys Glu 
        355                 360                 365             


Val Ile Thr Asp Asn Leu Pro Gly Ser Ile Arg Ala Val Val Asn Ile 
    370                 375                 380                 


Phe Leu Val Ala Lys Ala Leu Leu Ser Tyr Pro Leu Pro Phe Phe Ala 
385                 390                 395                 400 


Ala Val Glu Val Leu Glu Lys Ser Leu Phe Gln Glu Gly Ser Arg Ala 
                405                 410                 415     


Phe Phe Pro Ala Cys Tyr Ser Gly Asp Gly Arg Leu Lys Ser Trp Gly 
            420                 425                 430         


Leu Thr Leu Arg Cys Ala Leu Val Val Phe Thr Leu Leu Met Ala Ile 
        435                 440                 445             


Tyr Val Pro His Phe Ala Leu Leu Met Gly Leu Thr Gly Ser Leu Thr 
    450                 455                 460                 


Gly Ala Gly Leu Cys Phe Leu Leu Pro Ser Leu Phe His Leu Arg Leu 
465                 470                 475                 480 


Leu Trp Arg Lys Leu Leu Trp His Gln Val Phe Phe Asp Val Ala Ile 
                485                 490                 495     


Phe Val Ile Gly Gly Ile Cys Ser Val Ser Gly Phe Val His Ser Leu 
            500                 505                 510         


Glu Gly Leu Ile Glu Ala Tyr Arg Thr Asn Ala Glu Asp 
        515                 520                 525 


<210>  5607
<211>  562
<212>  PRT
<213>  Homo sapiens

<400>  5607

Met Ser Arg Ser Leu Leu Leu Trp Phe Leu Leu Phe Leu Leu Leu Leu 
1               5                   10                  15      


Pro Pro Leu Pro Val Leu Leu Ala Asp Pro Gly Ala Pro Thr Pro Val 
            20                  25                  30          


Asn Pro Cys Cys Tyr Tyr Pro Cys Gln His Gln Gly Ile Cys Val Arg 
        35                  40                  45              


Phe Gly Leu Asp Arg Tyr Gln Cys Asp Cys Thr Arg Thr Gly Tyr Ser 
    50                  55                  60                  


Gly Pro Asn Cys Thr Ile Pro Gly Leu Trp Thr Trp Leu Arg Asn Ser 
65                  70                  75                  80  


Leu Arg Pro Ser Pro Ser Phe Thr His Phe Leu Leu Thr His Gly Arg 
                85                  90                  95      


Trp Phe Trp Glu Phe Val Asn Ala Thr Phe Ile Arg Glu Met Leu Met 
            100                 105                 110         


Arg Leu Val Leu Thr Val Arg Ser Asn Leu Ile Pro Ser Pro Pro Thr 
        115                 120                 125             


Tyr Asn Ser Ala His Asp Tyr Ile Ser Trp Glu Ser Phe Ser Asn Val 
    130                 135                 140                 


Ser Tyr Tyr Thr Arg Ile Leu Pro Ser Val Pro Lys Asp Cys Pro Thr 
145                 150                 155                 160 


Pro Met Gly Thr Lys Gly Lys Lys Gln Leu Pro Asp Ala Gln Leu Leu 
                165                 170                 175     


Ala Arg Arg Phe Leu Leu Arg Arg Lys Phe Ile Pro Asp Pro Gln Gly 
            180                 185                 190         


Thr Asn Leu Met Phe Ala Phe Phe Ala Gln His Phe Thr His Gln Phe 
        195                 200                 205             


Phe Lys Thr Ser Gly Lys Met Gly Pro Gly Phe Thr Lys Ala Leu Gly 
    210                 215                 220                 


His Gly Val Asp Leu Gly His Ile Tyr Gly Asp Asn Leu Glu Arg Gln 
225                 230                 235                 240 


Tyr Gln Leu Arg Leu Phe Lys Asp Gly Lys Leu Lys Tyr Gln Val Leu 
                245                 250                 255     


Asp Gly Glu Met Tyr Pro Pro Ser Val Glu Glu Ala Pro Val Leu Met 
            260                 265                 270         


His Tyr Pro Arg Gly Ile Pro Pro Gln Ser Gln Met Ala Val Gly Gln 
        275                 280                 285             


Glu Val Phe Gly Leu Leu Pro Gly Leu Met Leu Tyr Ala Thr Leu Trp 
    290                 295                 300                 


Leu Arg Glu His Asn Arg Val Cys Asp Leu Leu Lys Ala Glu His Pro 
305                 310                 315                 320 


Thr Trp Gly Asp Glu Gln Leu Phe Gln Thr Thr Arg Leu Ile Leu Ile 
                325                 330                 335     


Gly Glu Thr Ile Lys Ile Val Ile Glu Glu Tyr Val Gln Gln Leu Ser 
            340                 345                 350         


Gly Tyr Phe Leu Gln Leu Lys Phe Asp Pro Glu Leu Leu Phe Gly Val 
        355                 360                 365             


Gln Phe Gln Tyr Arg Asn Arg Ile Ala Met Glu Phe Asn His Leu Tyr 
    370                 375                 380                 


His Trp His Pro Leu Met Pro Asp Ser Phe Lys Ile Gly Gly Gly Arg 
385                 390                 395                 400 


Asn Met Asp His His Ile Leu His Val Ala Val Asp Val Ile Arg Glu 
                405                 410                 415     


Ser Arg Glu Met Arg Leu Gln Pro Phe Asn Glu Tyr Arg Lys Arg Phe 
            420                 425                 430         


Gly Met Lys Pro Tyr Thr Ser Phe Gln Glu Leu Val Gly Glu Lys Glu 
        435                 440                 445             


Met Ala Ala Glu Leu Glu Glu Leu Tyr Gly Asp Ile Asp Ala Leu Glu 
    450                 455                 460                 


Phe Tyr Pro Gly Leu Leu Leu Glu Lys Cys His Pro Asn Ser Ile Phe 
465                 470                 475                 480 


Gly Glu Ser Met Ile Glu Ile Gly Ala Pro Phe Ser Leu Lys Gly Leu 
                485                 490                 495     


Leu Gly Asn Pro Ile Cys Ser Pro Glu Tyr Trp Lys Pro Ser Thr Phe 
            500                 505                 510         


Gly Gly Glu Val Gly Phe Asn Ile Val Lys Thr Ala Thr Leu Lys Lys 
        515                 520                 525             


Leu Val Cys Leu Asn Thr Lys Thr Cys Pro Tyr Val Ser Phe Arg Val 
    530                 535                 540                 


Pro Asp Ala Ser Gln Asp Asp Gly Pro Ala Val Glu Arg Pro Ser Thr 
545                 550                 555                 560 


Glu Leu 
        


<210>  5608
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  5608

Met Lys Thr Ser Ala Glu Leu His Glu Gln Glu Lys Pro Pro Ser Ser 
1               5                   10                  15      


Pro Arg Ala Thr Gly Pro Gly Arg Leu Gly His Ala Arg Gly Arg Gly 
            20                  25                  30          


Pro Asp Ala Leu Arg Gly Gly Ala Ala Gly Pro Gly Arg Ala Ser Ser 
        35                  40                  45              


Gly Ala Pro Arg Glu Arg Lys Met Ala Pro His Asp Pro Gly Ser Leu 
    50                  55                  60                  


Thr Thr Leu Val Pro Trp Ala Ala Ala Leu Leu Leu Ala Leu Gly Val 
65                  70                  75                  80  


Glu Arg Ala Leu Ala Leu Pro Glu Ile Cys Thr Gln Cys Pro Gly Ser 
                85                  90                  95      


Val Gln Asn Leu Ser Lys Val Ala Phe Tyr Cys Lys Thr Thr Arg Glu 
            100                 105                 110         


Leu Met Leu His Ala Arg Cys Cys Leu Asn Gln Lys Gly Thr Ile Leu 
        115                 120                 125             


Gly Leu Asp Leu Gln Asn Cys Ser Leu Glu Asp Pro Gly Pro Asn Phe 
    130                 135                 140                 


His Gln Ala His Thr Thr Val Ile Ile Asp Leu Gln Ala Asn Pro Leu 
145                 150                 155                 160 


Lys Gly Asp Leu Ala Asn Thr Phe Arg Gly Phe Thr Gln Leu Gln Thr 
                165                 170                 175     


Leu Ile Leu Pro Gln His Val Asn Cys Pro Gly Gly Ile Asn Ala Trp 
            180                 185                 190         


Asn Thr Ile Thr Ser Tyr Ile Asp Asn Gln Ile Cys Gln Gly Gln Lys 
        195                 200                 205             


Asn Leu Cys Asn Asn Thr Gly Asp Pro Glu Met Cys Pro Glu Asn Gly 
    210                 215                 220                 


Ser Cys Val Pro Asp Gly Pro Gly Leu Leu Gln Cys Val Cys Ala Asp 
225                 230                 235                 240 


Gly Phe His Gly Tyr Lys Cys Met Arg Gln Gly Ser Phe Ser Leu Leu 
                245                 250                 255     


Met Phe Phe Gly Ile Leu Gly Ala Thr Thr Leu Ser Val Ser Ile Leu 
            260                 265                 270         


Leu Trp Ala Thr Gln Arg Arg Lys Ala Lys Thr Ser 
        275                 280                 


<210>  5609
<211>  582
<212>  PRT
<213>  Homo sapiens

<400>  5609

Met Ile Phe Leu Thr Ala Leu Pro Leu Phe Trp Ile Met Ile Ser Ala 
1               5                   10                  15      


Ser Arg Gly Gly His Trp Gly Ala Trp Met Pro Ser Ser Ile Ser Ala 
            20                  25                  30          


Phe Glu Gly Thr Cys Val Ser Ile Pro Cys Arg Phe Asp Phe Pro Asp 
        35                  40                  45              


Glu Leu Arg Pro Ala Val Val His Gly Val Trp Tyr Phe Asn Ser Pro 
    50                  55                  60                  


Tyr Pro Lys Asn Tyr Pro Pro Val Val Phe Lys Ser Arg Thr Gln Val 
65                  70                  75                  80  


Val His Glu Ser Phe Gln Gly Arg Ser Arg Leu Leu Gly Asp Leu Gly 
                85                  90                  95      


Leu Arg Asn Cys Thr Leu Leu Leu Ser Asn Val Ser Pro Glu Leu Gly 
            100                 105                 110         


Gly Lys Tyr Tyr Phe Arg Gly Asp Leu Gly Gly Tyr Asn Gln Tyr Thr 
        115                 120                 125             


Phe Ser Glu His Ser Val Leu Asp Ile Val Asn Thr Pro Asn Ile Val 
    130                 135                 140                 


Val Pro Pro Glu Val Val Ala Gly Thr Glu Val Glu Val Ser Cys Met 
145                 150                 155                 160 


Val Pro Asp Asn Cys Pro Glu Leu Arg Pro Glu Leu Ser Trp Leu Gly 
                165                 170                 175     


His Glu Gly Leu Gly Glu Pro Ala Val Leu Gly Arg Leu Arg Glu Asp 
            180                 185                 190         


Glu Gly Thr Trp Val Gln Val Ser Leu Leu His Phe Val Pro Thr Arg 
        195                 200                 205             


Glu Ala Asn Gly His Arg Leu Gly Cys Gln Ala Ser Phe Pro Asn Thr 
    210                 215                 220                 


Thr Leu Gln Phe Glu Gly Tyr Ala Ser Met Asp Val Lys Tyr Pro Pro 
225                 230                 235                 240 


Val Ile Val Glu Met Asn Ser Ser Val Glu Ala Ile Glu Gly Ser His 
                245                 250                 255     


Val Ser Leu Leu Cys Gly Ala Asp Ser Asn Pro Pro Pro Leu Leu Thr 
            260                 265                 270         


Trp Met Arg Asp Gly Thr Val Leu Arg Glu Ala Val Ala Glu Ser Leu 
        275                 280                 285             


Leu Leu Glu Leu Glu Glu Val Thr Pro Ala Glu Asp Gly Val Tyr Ala 
    290                 295                 300                 


Cys Leu Ala Glu Asn Ala Tyr Gly Gln Asp Asn Arg Thr Val Gly Leu 
305                 310                 315                 320 


Ser Val Met Tyr Ala Pro Trp Lys Pro Thr Val Asn Gly Thr Met Val 
                325                 330                 335     


Ala Val Glu Gly Glu Thr Val Ser Ile Leu Cys Ser Thr Gln Ser Asn 
            340                 345                 350         


Pro Asp Pro Ile Leu Thr Ile Phe Lys Glu Lys Gln Ile Leu Ser Thr 
        355                 360                 365             


Val Ile Tyr Glu Ser Glu Leu Gln Leu Glu Leu Pro Ala Val Ser Pro 
    370                 375                 380                 


Glu Asp Asp Gly Glu Tyr Trp Cys Val Ala Glu Asn Gln Tyr Gly Gln 
385                 390                 395                 400 


Arg Ala Thr Ala Phe Asn Leu Ser Val Glu Phe Ala Pro Val Leu Leu 
                405                 410                 415     


Leu Glu Ser His Cys Ala Ala Ala Arg Asp Thr Val Gln Cys Leu Cys 
            420                 425                 430         


Val Val Lys Ser Asn Pro Glu Pro Ser Val Ala Phe Glu Leu Pro Ser 
        435                 440                 445             


Arg Asn Val Thr Val Asn Glu Ser Glu Arg Glu Phe Val Tyr Ser Glu 
    450                 455                 460                 


Arg Ser Gly Leu Val Leu Thr Ser Ile Leu Thr Leu Arg Gly Gln Ala 
465                 470                 475                 480 


Gln Ala Pro Pro Arg Val Ile Cys Thr Ala Arg Asn Leu Tyr Gly Ala 
                485                 490                 495     


Lys Ser Leu Glu Leu Pro Phe Gln Gly Ala His Arg Leu Met Trp Ala 
            500                 505                 510         


Lys Ile Gly Pro Val Gly Ala Val Val Ala Phe Ala Ile Leu Ile Ala 
        515                 520                 525             


Ile Val Cys Tyr Ile Thr Gln Thr Arg Arg Lys Lys Asn Val Thr Glu 
    530                 535                 540                 


Ser Pro Ser Phe Ser Ala Gly Asp Asn Pro Pro Val Leu Phe Ser Ser 
545                 550                 555                 560 


Asp Phe Arg Ile Ser Gly Ala Pro Glu Lys Tyr Glu Ser Lys Glu Val 
                565                 570                 575     


Ser Thr Leu Glu Ser His 
            580         


<210>  5610
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  5610

Met Lys Leu Leu Arg Arg Ala Trp Arg Arg Arg Ala Ala Leu Gly Leu 
1               5                   10                  15      


Gly Thr Leu Ala Leu Cys Gly Ala Ala Leu Leu Tyr Leu Ala Arg Cys 
            20                  25                  30          


Ala Ala Glu Pro Gly Asp Pro Arg Ala Met Ser Gly Arg Ser Pro Pro 
        35                  40                  45              


Pro Pro Ala Pro Ala Arg Ala Ala Ala Phe Leu Ala Val Leu Val Ala 
    50                  55                  60                  


Ser Ala Pro Arg Ala Ala Glu Arg Arg Ser Val Ile Arg Ser Thr Trp 
65                  70                  75                  80  


Leu Ala Arg Arg Gly Ala Pro Gly Asp Val Trp Ala Arg Phe Ala Val 
                85                  90                  95      


Gly Thr Ala Gly Leu Gly Ala Glu Glu Arg Arg Ala Leu Glu Arg Glu 
            100                 105                 110         


Gln Ala Arg His Gly Asp Leu Leu Leu Leu Pro Ala Leu Arg Asp Ala 
        115                 120                 125             


Tyr Glu Asn Leu Thr Ala Lys Val Leu Ala Met Leu Ala Trp Leu Asp 
    130                 135                 140                 


Glu His Val Ala Phe Glu Phe Val Leu Lys Ala Asp Asp Asp Ser Phe 
145                 150                 155                 160 


Ala Arg Leu Asp Ala Leu Leu Ala Glu Leu Arg Ala Arg Glu Pro Ala 
                165                 170                 175     


Arg Arg Arg Arg Leu Tyr Trp Gly Phe Phe Ser Gly Arg Gly Arg Val 
            180                 185                 190         


Lys Pro Gly Gly Arg Trp Arg Glu Ala Ala Trp Gln Leu Cys Asp Tyr 
        195                 200                 205             


Tyr Leu Pro Tyr Ala Leu Gly Gly Gly Tyr Val Leu Ser Ala Asp Leu 
    210                 215                 220                 


Val His Tyr Leu Arg Leu Ser Arg Asp Tyr Leu Arg Ala Trp His Ser 
225                 230                 235                 240 


Glu Asp Val Ser Leu Gly Ala Trp Leu Ala Pro Val Asp Val Gln Arg 
                245                 250                 255     


Glu His Asp Pro Arg Phe Asp Thr Glu Tyr Arg Ser Arg Gly Cys Ser 
            260                 265                 270         


Asn Gln Tyr Leu Val Thr His Lys Gln Ser Leu Glu Asp Met Leu Glu 
        275                 280                 285             


Lys His Ala Thr Leu Ala Arg Glu Gly Arg Leu Cys Lys Arg Glu Val 
    290                 295                 300                 


Gln Leu Arg Leu Ser Tyr Val Tyr Asp Trp Ser Ala Pro Pro Ser Gln 
305                 310                 315                 320 


Cys Cys Gln Arg Arg Glu Gly Ile Pro 
                325                 


<210>  5611
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  5611

Met Leu Gly Leu Pro Trp Lys Gly Gly Leu Ser Trp Ala Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Gly Ser Gln Ile Leu Leu Ile Tyr Ala Trp His Phe His 
            20                  25                  30          


Glu Gln Arg Asp Cys Asp Glu His Asn Val Met Ala Arg Tyr Leu Pro 
        35                  40                  45              


Ala Thr Val Glu Phe Ala Val His Thr Phe Asn Gln Gln Ser Lys Asp 
    50                  55                  60                  


Tyr Tyr Ala Tyr Arg Leu Gly His Ile Leu Asn Ser Trp Lys Glu Gln 
65                  70                  75                  80  


Val Glu Ser Lys Thr Val Phe Ser Met Glu Leu Leu Leu Gly Arg Thr 
                85                  90                  95      


Arg Cys Gly Lys Phe Glu Asp Asp Ile Asp Asn Cys His Phe Gln Glu 
            100                 105                 110         


Ser Thr Glu Leu Asn Asn Thr Phe Thr Cys Phe Phe Thr Ile Ser Thr 
        115                 120                 125             


Arg Pro Trp Met Thr Gln Phe Ser Leu Leu Asn Lys Thr Cys Leu Glu 
    130                 135                 140                 


Gly Phe His 
145         


<210>  5612
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  5612

Met Arg Pro Leu Leu Gly Leu Leu Leu Val Phe Ala Gly Cys Thr Phe 
1               5                   10                  15      


Ala Leu Tyr Leu Leu Ser Thr Arg Leu Pro Arg Gly Arg Arg Leu Gly 
            20                  25                  30          


Ser Thr Glu Glu Ala Gly Gly Arg Ser Leu Trp Phe Pro Ser Asp Leu 
        35                  40                  45              


Ala Glu Leu Arg Glu Leu Ser Glu Val Leu Arg Glu Tyr Arg Lys Glu 
    50                  55                  60                  


His Gln Ala Tyr Val Phe Leu Leu Phe Cys Gly Ala Tyr Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Phe Ala Ile Pro Gly Ser Ser Phe Leu Asn Val Leu Ala Gly 
                85                  90                  95      


Ala Leu Phe Gly Pro Trp Leu Gly Leu Leu Leu Cys Cys Val Leu Thr 
            100                 105                 110         


Ser Val Gly Ala Thr Cys Cys Tyr Leu Leu Ser Ser Ile Phe Gly Lys 
        115                 120                 125             


Gln Leu Val Val Ser Tyr Phe Pro Asp Lys Val Ala Leu Leu Gln Arg 
    130                 135                 140                 


Lys Val Glu Glu Asn Arg Asn Ser Leu Phe Phe Phe Leu Leu Phe Leu 
145                 150                 155                 160 


Arg Leu Phe Pro Met Thr Pro Asn Trp Phe Leu Asn Leu Ser Ala Pro 
                165                 170                 175     


Ile Leu Asn Ile Pro Ile Val Gln Phe Phe Phe Ser Val Leu Ile Gly 
            180                 185                 190         


Leu Ile Pro Tyr Asn Phe Ile Cys Val Gln Thr Gly Ser Ile Leu Ser 
        195                 200                 205             


Thr Leu Thr Ser Leu Asp Ala Leu Phe Ser Trp Asp Thr Val Phe Lys 
    210                 215                 220                 


Leu Leu Ala Ile Ala Met Val Ala Leu Ile Pro Gly Thr Leu Ile Lys 
225                 230                 235                 240 


Lys Phe Ser Gln Lys His Leu Gln Leu Asn Glu Thr Ser Thr Ala Asn 
                245                 250                 255     


His Ile His Ser Arg Lys Asp Thr 
            260                 


<210>  5613
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  5613

Met Ala Ser Leu Ser Gly Leu Ala Ser Ala Leu Glu Ser Tyr Arg Gly 
1               5                   10                  15      


Arg Asp Arg Leu Ile Arg Val Leu Gly Tyr Cys Cys Gln Leu Val Gly 
            20                  25                  30          


Gly Val Leu Val Glu Gln Cys Pro Ala Arg Ser Glu Val Gly Thr Arg 
        35                  40                  45              


Leu Leu Val Val Ser Thr Gln Leu Ser His Cys Arg Thr Ile Leu Arg 
    50                  55                  60                  


Leu Phe Asp Asp Leu Ala Met Phe Val Tyr Thr Lys Gln Tyr Gly Leu 
65                  70                  75                  80  


Gly Ala Gln Glu Glu Asp Ala Phe Val Arg Cys Val Ser Val Leu Gly 
                85                  90                  95      


Asn Leu Ala Asp Gln Leu Tyr Tyr Pro Cys Glu His Val Ala Trp Ala 
            100                 105                 110         


Ala Asp Ala Arg Val Leu His Val Asp Ser Ser Arg Trp Trp Thr Leu 
        115                 120                 125             


Ser Thr Thr Leu Trp Ala Leu Ser Leu Leu Leu Gly Val Ala Arg Ser 
    130                 135                 140                 


Leu Trp Met Leu Leu Lys Leu Arg Gln Arg Leu Arg Ser Pro Thr Ala 
145                 150                 155                 160 


Pro Phe Thr Ser Pro Leu Pro Arg Gly Lys Arg Arg Ala Met Glu Ala 
                165                 170                 175     


Gln Met Gln Ser Glu Ala Leu Ser Leu Leu Ser Asn Leu Ala Asp Leu 
            180                 185                 190         


Ala Asn Ala Val His Trp Leu Pro Arg Gly Val Leu Trp Ala Gly Arg 
        195                 200                 205             


Phe Pro Pro Trp Leu Val Gly Leu Met Gly Thr Ile Ser Ser Ile Leu 
    210                 215                 220                 


Ser Met Tyr Gln Ala Ala Arg Ala Gly Gly Gln Ala Glu Ala Thr Thr 
225                 230                 235                 240 


Pro 
    


<210>  5614
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  5614

Met Glu Gly Ser Ala Ser Pro Pro Glu Lys Pro Arg Ala Arg Pro Ala 
1               5                   10                  15      


Ala Ala Val Leu Cys Arg Gly Pro Val Glu Pro Leu Val Phe Leu Ala 
            20                  25                  30          


Asn Phe Ala Leu Val Leu Gln Gly Pro Leu Thr Thr Gln Tyr Leu Trp 
        35                  40                  45              


His Arg Phe Ser Ala Asp Leu Gly Tyr Asn Gly Thr Arg Gln Arg Gly 
    50                  55                  60                  


Gly Cys Ser Asn Arg Ser Ala Asp Pro Thr Met Gln Glu Val Glu Thr 
65                  70                  75                  80  


Leu Thr Ser His Trp Thr Leu Tyr Met Asn Val Gly Gly Phe Leu Val 
                85                  90                  95      


Gly Leu Phe Ser Ser Thr Leu Leu Gly Ala Trp Ser Asp Ser Val Gly 
            100                 105                 110         


Arg Arg Pro Leu Leu Val Leu Ala Ser Leu Gly Leu Leu Leu Gln Ala 
        115                 120                 125             


Leu Val Ser Val Phe Val Val Gln Leu Gln Leu His Val Gly Tyr Phe 
    130                 135                 140                 


Val Leu Gly Arg Ile Leu Cys Ala Leu Leu Gly Asp Phe Gly Gly Leu 
145                 150                 155                 160 


Leu Ala Ala Ser Phe Ala Ser Val Ala Asp Val Ser Ser Ser Arg Ser 
                165                 170                 175     


Arg Thr Phe Arg Met Ala Leu Leu Glu Ala Ser Ile Gly Val Ala Gly 
            180                 185                 190         


Met Leu Ala Ser Leu Leu Gly Gly His Trp Leu Arg Ala Gln Gly Tyr 
        195                 200                 205             


Ala Asn Pro Phe Trp Leu Ala Leu Ala Leu Leu Ile Ala Met Thr Leu 
    210                 215                 220                 


Tyr Ala Ala Phe Cys Phe Gly Glu Thr Leu Lys Glu Pro Lys Ser Thr 
225                 230                 235                 240 


Arg Leu Phe Thr Phe Arg His His Arg Ser Ile Val Gln Leu Tyr Val 
                245                 250                 255     


Ala Pro Ala Pro Glu Lys Ser Arg Lys His Leu Ala Leu Tyr Ser Leu 
            260                 265                 270         


Ala Ile Phe Val Val Ile Thr Val His Phe Gly Ala Gln Asp Ile Leu 
        275                 280                 285             


Thr Leu Tyr Glu Leu Ser Thr Pro Leu Cys Trp Asp Ser Lys Leu Ile 
    290                 295                 300                 


Gly Tyr Gly Ser Ala Ala Gln His Leu Pro Tyr Leu Thr Ser Leu Leu 
305                 310                 315                 320 


Ala Leu Lys Leu Leu Gln Tyr Cys Leu Ala Asp Ala Trp Val Ala Glu 
                325                 330                 335     


Ile Gly Leu Ala Phe Asn Ile Leu Gly Met Val Val Phe Ala Phe Ala 
            340                 345                 350         


Thr Ile Thr Pro Leu Met Phe Thr Gly Tyr Gly Leu Leu Phe Leu Ser 
        355                 360                 365             


Leu Val Ile Thr Pro Val Ile Arg Ala Lys Leu Ser Lys Leu Val Arg 
    370                 375                 380                 


Glu Thr Glu Gln Gly Ala Leu Phe Ser Ala Val Ala Cys Val Asn Ser 
385                 390                 395                 400 


Leu Ala Met Leu Thr Ala Ser Gly Ile Phe Asn Ser Leu Tyr Pro Ala 
                405                 410                 415     


Thr Leu Asn Phe Met Lys Gly Phe Pro Phe Leu Leu Gly Ala Gly Leu 
            420                 425                 430         


Leu Leu Ile Pro Ala Val Leu Ile Gly Met Leu Glu Lys Ala Asp Pro 
        435                 440                 445             


His Leu Glu Phe Gln Gln Phe Pro Gln Ser Pro 
    450                 455                 


<210>  5615
<211>  324
<212>  PRT
<213>  Homo sapiens

<400>  5615

Met Ser Val Glu Asp Gly Gly Met Pro Gly Leu Gly Arg Pro Arg Gln 
1               5                   10                  15      


Ala Arg Trp Thr Leu Met Leu Leu Leu Ser Thr Ala Met Tyr Gly Ala 
            20                  25                  30          


His Ala Pro Leu Leu Ala Leu Cys His Val Asp Gly Arg Val Pro Phe 
        35                  40                  45              


Arg Pro Ser Ser Ala Val Leu Leu Thr Glu Leu Thr Lys Leu Leu Leu 
    50                  55                  60                  


Cys Ala Phe Ser Leu Leu Val Gly Trp Gln Ala Trp Pro Gln Gly Pro 
65                  70                  75                  80  


Pro Pro Trp Arg Gln Ala Ala Pro Phe Ala Leu Ser Ala Leu Leu Tyr 
                85                  90                  95      


Gly Ala Asn Asn Asn Leu Val Ile Tyr Leu Gln Arg Tyr Met Asp Pro 
            100                 105                 110         


Ser Thr Tyr Gln Val Leu Ser Asn Leu Lys Ile Gly Ser Thr Ala Val 
        115                 120                 125             


Leu Tyr Cys Leu Cys Leu Arg His Arg Leu Ser Val Arg Gln Gly Leu 
    130                 135                 140                 


Ala Leu Leu Leu Leu Met Ala Ala Gly Ala Cys Tyr Ala Ala Gly Gly 
145                 150                 155                 160 


Leu Gln Val Pro Gly Asn Thr Leu Pro Ser Pro Pro Pro Ala Ala Ala 
                165                 170                 175     


Ala Ser Pro Met Pro Leu His Ile Thr Pro Leu Gly Leu Leu Leu Leu 
            180                 185                 190         


Ile Leu Tyr Cys Leu Ile Ser Gly Leu Ser Ser Val Tyr Thr Glu Leu 
        195                 200                 205             


Leu Met Lys Arg Gln Arg Leu Pro Leu Ala Leu Gln Asn Leu Phe Leu 
    210                 215                 220                 


Tyr Thr Phe Gly Val Leu Leu Asn Leu Gly Leu His Ala Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Pro Gly Leu Leu Glu Gly Phe Ser Gly Trp Ala Ala Leu Val 
                245                 250                 255     


Val Leu Ser Gln Ala Leu Asn Gly Leu Leu Met Ser Ala Val Met Lys 
            260                 265                 270         


His Gly Ser Ser Ile Thr Arg Leu Phe Val Val Ser Cys Ser Leu Val 
        275                 280                 285             


Val Asn Ala Val Leu Ser Ala Val Leu Leu Arg Leu Gln Leu Thr Ala 
    290                 295                 300                 


Ala Phe Phe Leu Ala Thr Leu Leu Ile Gly Leu Ala Met Arg Leu Tyr 
305                 310                 315                 320 


Tyr Gly Ser Arg 
                


<210>  5616
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  5616

Met His Phe Leu Thr Ile Tyr Pro Asn Cys Ser Ser Gly Val Val Arg 
1               5                   10                  15      


Ala Gln Ser Arg Thr Glu Gln Lys Asn Pro Leu Gly Leu Asp Asp Leu 
            20                  25                  30          


Gly Ile Gln Asn Leu Gly Gln Thr Val Ser Leu Ala Pro Ala Val Glu 
        35                  40                  45              


Ala Ala Ser Met Leu Lys Met Glu Pro Leu Asn Ser Thr His Pro Gly 
    50                  55                  60                  


Thr Ala Ala Ser Ser Ser Pro Leu Glu Ser Arg Ala Ala Gly Gly Gly 
65                  70                  75                  80  


Ser Gly Asn Gly Asn Glu Tyr Phe Tyr Ile Leu Val Val Met Ser Phe 
                85                  90                  95      


Tyr Gly Ile Phe Leu Ile Gly Ile Met Leu Gly Tyr Met Lys Ser Lys 
            100                 105                 110         


Arg Arg Glu Lys Lys Ser Ser Leu Leu Leu Leu Tyr Lys Asp Glu Glu 
        115                 120                 125             


Arg Leu Trp Gly Glu Ala Met Lys Pro Leu Pro Val Val Ser Gly Leu 
    130                 135                 140                 


Arg Ser Val Gln Val Pro Leu Met Leu Asn Met Leu Gln Glu Ser Val 
145                 150                 155                 160 


Ala Pro Ala Leu Ser Cys Thr Leu Cys Ser Met Glu Gly Asp Ser Val 
                165                 170                 175     


Ser Ser Glu Ser Ser Ser Pro Asp Val His Leu Thr Ile Gln Glu Glu 
            180                 185                 190         


Gly Ala Asp Asp Glu Leu Glu Glu Thr Ser Glu Thr Pro Leu Asn Glu 
        195                 200                 205             


Ser Ser Glu Gly Ser Ser Glu Asn Ile His Gln Asn Ser 
    210                 215                 220     


<210>  5617
<211>  1629
<212>  PRT
<213>  Homo sapiens

<400>  5617

Met Glu Arg Cys Ser Arg Cys His Arg Leu Leu Leu Leu Leu Pro Leu 
1               5                   10                  15      


Val Leu Gly Leu Ser Ala Ala Pro Gly Trp Ala Gly Ala Pro Pro Val 
            20                  25                  30          


Asp Val Leu Arg Ala Leu Arg Phe Pro Ser Leu Pro Asp Gly Val Arg 
        35                  40                  45              


Arg Ala Lys Gly Ile Cys Pro Ala Asp Val Ala Tyr Arg Val Ala Arg 
    50                  55                  60                  


Pro Ala Gln Leu Ser Ala Pro Thr Arg Gln Leu Phe Pro Gly Gly Phe 
65                  70                  75                  80  


Pro Lys Asp Phe Ser Leu Leu Thr Val Val Arg Thr Arg Pro Gly Leu 
                85                  90                  95      


Gln Ala Pro Leu Leu Thr Leu Tyr Ser Ala Gln Gly Val Arg Gln Leu 
            100                 105                 110         


Gly Leu Glu Leu Gly Arg Pro Val Arg Phe Leu Tyr Glu Asp Gln Thr 
        115                 120                 125             


Gly Arg Pro Gln Pro Pro Ser Gln Pro Val Phe Arg Gly Leu Ser Leu 
    130                 135                 140                 


Ala Asp Gly Lys Trp His Arg Val Ala Val Ala Val Lys Gly Gln Ser 
145                 150                 155                 160 


Val Thr Leu Ile Val Asp Cys Lys Lys Arg Val Thr Arg Pro Leu Pro 
                165                 170                 175     


Arg Ser Ala Arg Pro Val Leu Asp Thr His Gly Val Ile Ile Phe Gly 
            180                 185                 190         


Ala Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Val Gln Glu Leu 
        195                 200                 205             


Ala Ile Val Pro Gly Val Gln Ala Ala Tyr Glu Ser Cys Glu Gln Lys 
    210                 215                 220                 


Glu Leu Glu Cys Glu Gly Gly Gln Arg Glu Arg Pro Gln Asn Gln Gln 
225                 230                 235                 240 


Pro His Arg Ala Gln Arg Ser Pro Gln Gln Gln Pro Ser Arg Leu His 
                245                 250                 255     


Arg Pro Gln Asn Gln Glu Pro Gln Ser Gln Ala Ala His Gly Pro Arg 
            260                 265                 270         


Gly Leu Lys Gly Glu Lys Gly Glu Pro Ala Val Leu Glu Pro Gly Met 
        275                 280                 285             


Leu Val Glu Gly Pro Pro Gly Pro Glu Gly Pro Ala Gly Leu Ile Gly 
    290                 295                 300                 


Pro Pro Gly Ile Gln Gly Asn Pro Gly Pro Val Gly Asp Pro Gly Glu 
305                 310                 315                 320 


Arg Gly Pro Pro Gly Arg Ala Gly Leu Pro Gly Ser Asp Gly Ala Pro 
                325                 330                 335     


Gly Pro Pro Gly Thr Ser Leu Met Leu Pro Phe Arg Phe Gly Ser Gly 
            340                 345                 350         


Gly Gly Asp Lys Gly Pro Val Val Ala Ala Gln Glu Ala Gln Ala Gln 
        355                 360                 365             


Ala Ile Leu Gln Gln Ala Arg Leu Ala Leu Arg Gly Pro Pro Gly Pro 
    370                 375                 380                 


Met Gly Tyr Thr Gly Arg Pro Gly Pro Leu Gly Gln Pro Gly Ser Pro 
385                 390                 395                 400 


Gly Leu Lys Gly Glu Ser Gly Asp Leu Gly Pro Gln Gly Pro Arg Gly 
                405                 410                 415     


Pro Gln Gly Leu Thr Gly Pro Pro Gly Lys Ala Gly Arg Arg Gly Arg 
            420                 425                 430         


Ala Gly Ala Asp Gly Ala Arg Gly Met Pro Gly Asp Pro Gly Val Lys 
        435                 440                 445             


Gly Asp Arg Gly Phe Asp Gly Leu Pro Gly Leu Pro Gly Glu Lys Gly 
    450                 455                 460                 


His Arg Gly Asp Thr Gly Ala Gln Gly Leu Pro Gly Pro Pro Gly Glu 
465                 470                 475                 480 


Asp Gly Glu Arg Gly Asp Asp Gly Glu Ile Gly Pro Arg Gly Leu Pro 
                485                 490                 495     


Gly Glu Ser Gly Pro Arg Gly Leu Leu Gly Pro Lys Gly Pro Pro Gly 
            500                 505                 510         


Ile Pro Gly Pro Pro Gly Val Arg Gly Met Asp Gly Pro Gln Gly Pro 
        515                 520                 525             


Lys Gly Ser Leu Gly Pro Gln Gly Glu Pro Gly Pro Pro Gly Gln Gln 
    530                 535                 540                 


Gly Thr Pro Gly Thr Gln Gly Leu Pro Gly Pro Gln Gly Ala Ile Gly 
545                 550                 555                 560 


Pro His Gly Glu Lys Gly Pro Gln Gly Lys Pro Gly Leu Pro Gly Met 
                565                 570                 575     


Pro Gly Ser Asp Gly Pro Pro Gly His Pro Gly Lys Glu Gly Pro Pro 
            580                 585                 590         


Gly Thr Lys Gly Asn Gln Gly Pro Ser Gly Pro Gln Gly Pro Leu Gly 
        595                 600                 605             


Tyr Pro Gly Pro Arg Gly Val Lys Gly Val Asp Gly Ile Arg Gly Leu 
    610                 615                 620                 


Lys Gly His Lys Gly Glu Lys Gly Glu Asp Gly Phe Pro Gly Phe Lys 
625                 630                 635                 640 


Gly Asp Ile Gly Val Lys Gly Asp Arg Gly Glu Val Gly Val Pro Gly 
                645                 650                 655     


Ser Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Arg Thr Gly Pro 
            660                 665                 670         


Thr Gly Asp Pro Gly Pro Pro Gly Leu Met Gly Glu Lys Gly Lys Leu 
        675                 680                 685             


Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg Gln Gly Pro Lys Gly 
    690                 695                 700                 


Ser Leu Gly Phe Pro Gly Phe Pro Gly Ala Ser Gly Glu Lys Gly Ala 
705                 710                 715                 720 


Arg Gly Leu Ser Gly Lys Ser Gly Pro Arg Gly Glu Arg Gly Pro Thr 
                725                 730                 735     


Gly Pro Arg Gly Gln Arg Gly Pro Arg Gly Ala Thr Gly Lys Ser Gly 
            740                 745                 750         


Ala Lys Gly Thr Ser Gly Gly Asp Gly Pro His Gly Pro Pro Gly Glu 
        755                 760                 765             


Arg Gly Leu Pro Gly Pro Gln Gly Pro Asn Gly Phe Pro Gly Pro Lys 
    770                 775                 780                 


Gly Pro Pro Gly Pro Pro Gly Lys Asp Gly Leu Pro Gly His Pro Gly 
785                 790                 795                 800 


Gln Arg Gly Glu Val Gly Phe Gln Gly Lys Thr Gly Pro Pro Gly Pro 
                805                 810                 815     


Pro Gly Val Val Gly Pro Gln Gly Ala Ala Gly Glu Thr Gly Pro Met 
            820                 825                 830         


Gly Glu Arg Gly His Pro Gly Pro Pro Gly Pro Pro Gly Glu Gln Gly 
        835                 840                 845             


Leu Pro Gly Thr Ala Gly Lys Glu Gly Thr Lys Gly Asp Pro Gly Pro 
    850                 855                 860                 


Pro Gly Ala Pro Gly Lys Asp Gly Pro Ala Gly Leu Arg Gly Phe Pro 
865                 870                 875                 880 


Gly Glu Arg Gly Leu Pro Gly Thr Ala Gly Gly Pro Gly Leu Lys Gly 
                885                 890                 895     


Asn Glu Gly Pro Ser Gly Pro Pro Gly Pro Ala Gly Ser Pro Gly Glu 
            900                 905                 910         


Arg Gly Ala Ala Gly Ser Gly Gly Pro Ile Gly Pro Pro Gly Arg Pro 
        915                 920                 925             


Gly Pro Gln Gly Pro Pro Gly Ala Ala Gly Glu Lys Gly Val Pro Gly 
    930                 935                 940                 


Glu Lys Gly Pro Ile Gly Pro Thr Gly Arg Asp Gly Val Gln Gly Pro 
945                 950                 955                 960 


Val Gly Leu Pro Gly Pro Ala Gly Pro Pro Gly Val Ala Gly Glu Asp 
                965                 970                 975     


Gly Asp Lys Gly Glu Val Gly Asp Pro Gly Gln Lys Gly Thr Lys Gly 
            980                 985                 990         


Asn Lys Gly Glu His Gly Pro Pro  Gly Pro Pro Gly Pro  Ile Gly Pro 
        995                 1000                 1005             


Val Gly  Gln Pro Gly Ala Ala  Gly Ala Asp Gly Glu  Pro Gly Ala 
    1010                 1015                 1020             


Arg Gly  Pro Gln Gly His Phe  Gly Ala Lys Gly Asp  Glu Gly Thr 
    1025                 1030                 1035             


Arg Gly  Phe Asn Gly Pro Pro  Gly Pro Ile Gly Leu  Gln Gly Leu 
    1040                 1045                 1050             


Pro Gly  Pro Ser Gly Glu Lys  Gly Glu Thr Gly Asp  Val Gly Pro 
    1055                 1060                 1065             


Met Gly  Pro Pro Gly Pro Pro  Gly Pro Arg Gly Pro  Ala Gly Pro 
    1070                 1075                 1080             


Asn Gly  Ala Asp Gly Pro Gln  Gly Pro Pro Gly Gly  Val Gly Asn 
    1085                 1090                 1095             


Leu Gly  Pro Pro Gly Glu Lys  Gly Glu Pro Gly Glu  Ser Gly Ser 
    1100                 1105                 1110             


Pro Gly  Ile Gln Gly Glu Pro  Gly Val Lys Gly Pro  Arg Gly Glu 
    1115                 1120                 1125             


Arg Gly  Glu Lys Gly Glu Ser  Gly Gln Pro Gly Glu  Pro Gly Pro 
    1130                 1135                 1140             


Pro Gly  Pro Lys Gly Pro Thr  Gly Asp Asp Gly Pro  Lys Gly Asn 
    1145                 1150                 1155             


Pro Gly  Pro Val Gly Phe Pro  Gly Asp Pro Gly Pro  Pro Gly Glu 
    1160                 1165                 1170             


Gly Gly  Pro Arg Gly Gln Asp  Gly Ala Lys Gly Asp  Arg Gly Glu 
    1175                 1180                 1185             


Asp Gly  Glu Pro Gly Gln Pro  Gly Ser Pro Gly Pro  Thr Gly Glu 
    1190                 1195                 1200             


Asn Gly  Pro Pro Gly Pro Leu  Gly Lys Arg Gly Pro  Ala Gly Ser 
    1205                 1210                 1215             


Pro Gly  Ser Glu Gly Arg Gln  Gly Gly Lys Gly Ala  Lys Gly Asp 
    1220                 1225                 1230             


Pro Gly  Ala Ile Gly Ala Pro  Gly Lys Thr Gly Pro  Val Gly Pro 
    1235                 1240                 1245             


Ala Gly  Pro Ala Gly Lys Pro  Gly Pro Asp Gly Leu  Arg Gly Leu 
    1250                 1255                 1260             


Pro Gly  Ser Val Gly Gln Gln  Gly Arg Pro Gly Ala  Thr Gly Gln 
    1265                 1270                 1275             


Ala Gly  Pro Pro Gly Pro Val  Gly Pro Pro Gly Leu  Pro Gly Leu 
    1280                 1285                 1290             


Arg Gly  Asp Ala Gly Ala Lys  Gly Glu Lys Gly His  Pro Gly Leu 
    1295                 1300                 1305             


Ile Gly  Leu Ile Gly Pro Pro  Gly Glu Gln Gly Glu  Lys Gly Asp 
    1310                 1315                 1320             


Arg Gly  Leu Pro Gly Pro Gln  Gly Ser Pro Gly Gln  Lys Gly Glu 
    1325                 1330                 1335             


Met Gly  Ile Pro Gly Ala Ser  Gly Pro Ile Gly Pro  Gly Gly Pro 
    1340                 1345                 1350             


Pro Gly  Leu Pro Gly Pro Ala  Gly Pro Lys Gly Ala  Lys Gly Ala 
    1355                 1360                 1365             


Thr Gly  Pro Gly Gly Pro Lys  Gly Glu Lys Gly Val  Gln Gly Pro 
    1370                 1375                 1380             


Pro Gly  His Pro Gly Pro Pro  Gly Glu Val Ile Gln  Pro Leu Pro 
    1385                 1390                 1395             


Ile Gln  Met Pro Lys Lys Thr  Arg Arg Ser Val Asp  Gly Ser Arg 
    1400                 1405                 1410             


Leu Met  Gln Glu Asp Glu Ala  Ile Pro Thr Gly Gly  Ala Pro Gly 
    1415                 1420                 1425             


Ser Pro  Gly Gly Leu Glu Glu  Ile Phe Gly Ser Leu  Asp Ser Leu 
    1430                 1435                 1440             


Arg Glu  Glu Ile Glu Gln Met  Arg Arg Pro Thr Gly  Thr Gln Asp 
    1445                 1450                 1455             


Ser Pro  Ala Arg Thr Cys Gln  Asp Leu Lys Leu Cys  His Pro Glu 
    1460                 1465                 1470             


Leu Pro  Asp Gly Glu Tyr Trp  Val Asp Pro Asn Gln  Gly Cys Ala 
    1475                 1480                 1485             


Arg Asp  Ala Phe Arg Val Phe  Cys Asn Phe Thr Ala  Gly Gly Glu 
    1490                 1495                 1500             


Thr Cys  Val Thr Pro Arg Asp  Asp Val Thr Gln Phe  Ser Tyr Val 
    1505                 1510                 1515             


Asp Ser  Glu Gly Ser Pro Val  Gly Val Val Gln Leu  Thr Phe Leu 
    1520                 1525                 1530             


Arg Leu  Leu Ser Val Ser Ala  His Gln Asp Val Ser  Tyr Pro Cys 
    1535                 1540                 1545             


Ser Gly  Ala Ala Arg Asp Gly  Pro Leu Arg Leu Arg  Gly Ala Asn 
    1550                 1555                 1560             


Glu Asp  Glu Leu Ser Pro Glu  Thr Ser Pro Tyr Val  Lys Glu Phe 
    1565                 1570                 1575             


Arg Asp  Gly Cys Gln Thr Gln  Gln Gly Arg Thr Val  Leu Glu Val 
    1580                 1585                 1590             


Arg Thr  Pro Val Leu Glu Gln  Leu Pro Val Leu Asp  Ala Ser Phe 
    1595                 1600                 1605             


Ser Asp  Leu Gly Ala Pro Pro  Arg Arg Gly Gly Val  Leu Leu Gly 
    1610                 1615                 1620             


Pro Val  Cys Phe Met Gly 
    1625                 


<210>  5618
<211>  1736
<212>  PRT
<213>  Homo sapiens

<400>  5618

Met Glu Arg Cys Ser Arg Cys His Arg Leu Leu Leu Leu Leu Pro Leu 
1               5                   10                  15      


Val Leu Gly Leu Ser Ala Ala Pro Gly Trp Ala Gly Ala Pro Pro Val 
            20                  25                  30          


Asp Val Leu Arg Ala Leu Arg Phe Pro Ser Leu Pro Asp Gly Val Arg 
        35                  40                  45              


Arg Ala Lys Gly Ile Cys Pro Ala Asp Val Ala Tyr Arg Val Ala Arg 
    50                  55                  60                  


Pro Ala Gln Leu Ser Ala Pro Thr Arg Gln Leu Phe Pro Gly Gly Phe 
65                  70                  75                  80  


Pro Lys Asp Phe Ser Leu Leu Thr Val Val Arg Thr Arg Pro Gly Leu 
                85                  90                  95      


Gln Ala Pro Leu Leu Thr Leu Tyr Ser Ala Gln Gly Val Arg Gln Leu 
            100                 105                 110         


Gly Leu Glu Leu Gly Arg Pro Val Arg Phe Leu Tyr Glu Asp Gln Thr 
        115                 120                 125             


Gly Arg Pro Gln Pro Pro Ser Gln Pro Val Phe Arg Gly Leu Ser Leu 
    130                 135                 140                 


Ala Asp Gly Lys Trp His Arg Val Ala Val Ala Val Lys Gly Gln Ser 
145                 150                 155                 160 


Val Thr Leu Ile Val Asp Cys Lys Lys Arg Val Thr Arg Pro Leu Pro 
                165                 170                 175     


Arg Ser Ala Arg Pro Val Leu Asp Thr His Gly Val Ile Ile Phe Gly 
            180                 185                 190         


Ala Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Val Gln Glu Leu 
        195                 200                 205             


Ala Ile Val Pro Gly Val Gln Ala Ala Tyr Glu Ser Cys Glu Gln Lys 
    210                 215                 220                 


Glu Leu Glu Cys Glu Gly Gly Gln Arg Glu Arg Pro Gln Asn Gln Gln 
225                 230                 235                 240 


Pro His Arg Ala Gln Arg Ser Pro Gln Gln Gln Pro Ser Arg Leu His 
                245                 250                 255     


Arg Pro Gln Asn Gln Glu Pro Gln Ser Gln Pro Thr Glu Ser Leu Tyr 
            260                 265                 270         


Tyr Asp Tyr Glu Pro Pro Tyr Tyr Asp Val Met Thr Thr Gly Thr Thr 
        275                 280                 285             


Pro Asp Tyr Gln Asp Pro Thr Pro Gly Glu Glu Glu Glu Ile Leu Glu 
    290                 295                 300                 


Ser Ser Leu Leu Pro Pro Leu Glu Glu Glu Gln Thr Asp Leu Gln Val 
305                 310                 315                 320 


Pro Pro Thr Ala Asp Arg Phe Gln Ala Glu Glu Tyr Gly Glu Gly Gly 
                325                 330                 335     


Thr Asp Pro Pro Glu Gly Pro Tyr Asp Tyr Thr Tyr Gly Tyr Gly Asp 
            340                 345                 350         


Asp Tyr Arg Glu Glu Thr Glu Leu Gly Pro Ala Leu Ser Ala Glu Thr 
        355                 360                 365             


Ala His Ser Gly Ala Ala Ala His Gly Pro Arg Gly Leu Lys Gly Glu 
    370                 375                 380                 


Lys Gly Glu Pro Ala Val Leu Glu Pro Gly Met Leu Val Glu Gly Pro 
385                 390                 395                 400 


Pro Gly Pro Glu Gly Pro Ala Gly Leu Ile Gly Pro Pro Gly Ile Gln 
                405                 410                 415     


Gly Asn Pro Gly Pro Val Gly Asp Pro Gly Glu Arg Gly Pro Pro Gly 
            420                 425                 430         


Arg Ala Gly Leu Pro Gly Ser Asp Gly Ala Pro Gly Pro Pro Gly Thr 
        435                 440                 445             


Ser Leu Met Leu Pro Phe Arg Phe Gly Ser Gly Gly Gly Asp Lys Gly 
    450                 455                 460                 


Pro Val Val Ala Ala Gln Glu Ala Gln Ala Gln Ala Ile Leu Gln Gln 
465                 470                 475                 480 


Ala Arg Leu Ala Leu Arg Gly Pro Pro Gly Pro Met Gly Tyr Thr Gly 
                485                 490                 495     


Arg Pro Gly Pro Leu Gly Gln Pro Gly Ser Pro Gly Leu Lys Gly Glu 
            500                 505                 510         


Ser Gly Asp Leu Gly Pro Gln Gly Pro Arg Gly Pro Gln Gly Leu Thr 
        515                 520                 525             


Gly Pro Pro Gly Lys Ala Gly Arg Arg Gly Arg Ala Gly Ala Asp Gly 
    530                 535                 540                 


Ala Arg Gly Met Pro Gly Asp Pro Gly Val Lys Gly Asp Arg Gly Phe 
545                 550                 555                 560 


Asp Gly Leu Pro Gly Leu Pro Gly Glu Lys Gly His Arg Gly Asp Thr 
                565                 570                 575     


Gly Ala Gln Gly Leu Pro Gly Pro Pro Gly Glu Asp Gly Glu Arg Gly 
            580                 585                 590         


Asp Asp Gly Glu Ile Gly Pro Arg Gly Leu Pro Gly Glu Ser Gly Pro 
        595                 600                 605             


Arg Gly Leu Leu Gly Pro Lys Gly Pro Pro Gly Ile Pro Gly Pro Pro 
    610                 615                 620                 


Gly Val Arg Gly Met Asp Gly Pro Gln Gly Pro Lys Gly Ser Leu Gly 
625                 630                 635                 640 


Pro Gln Gly Glu Pro Gly Pro Pro Gly Gln Gln Gly Thr Pro Gly Thr 
                645                 650                 655     


Gln Gly Leu Pro Gly Pro Gln Gly Ala Ile Gly Pro His Gly Glu Lys 
            660                 665                 670         


Gly Pro Gln Gly Lys Pro Gly Leu Pro Gly Met Pro Gly Ser Asp Gly 
        675                 680                 685             


Pro Pro Gly His Pro Gly Lys Glu Gly Pro Pro Gly Thr Lys Gly Asn 
    690                 695                 700                 


Gln Gly Pro Ser Gly Pro Gln Gly Pro Leu Gly Tyr Pro Gly Pro Arg 
705                 710                 715                 720 


Gly Val Lys Gly Val Asp Gly Ile Arg Gly Leu Lys Gly His Lys Gly 
                725                 730                 735     


Glu Lys Gly Glu Asp Gly Phe Pro Gly Phe Lys Gly Asp Ile Gly Val 
            740                 745                 750         


Lys Gly Asp Arg Gly Glu Val Gly Val Pro Gly Ser Arg Gly Glu Asp 
        755                 760                 765             


Gly Pro Glu Gly Pro Lys Gly Arg Thr Gly Pro Thr Gly Asp Pro Gly 
    770                 775                 780                 


Pro Pro Gly Leu Met Gly Glu Lys Gly Lys Leu Gly Val Pro Gly Leu 
785                 790                 795                 800 


Pro Gly Tyr Pro Gly Arg Gln Gly Pro Lys Gly Ser Leu Gly Phe Pro 
                805                 810                 815     


Gly Phe Pro Gly Ala Ser Gly Glu Lys Gly Ala Arg Gly Leu Ser Gly 
            820                 825                 830         


Lys Ser Gly Pro Arg Gly Glu Arg Gly Pro Thr Gly Pro Arg Gly Gln 
        835                 840                 845             


Arg Gly Pro Arg Gly Ala Thr Gly Lys Ser Gly Ala Lys Gly Thr Ser 
    850                 855                 860                 


Gly Gly Asp Gly Pro His Gly Pro Pro Gly Glu Arg Gly Leu Pro Gly 
865                 870                 875                 880 


Pro Gln Gly Pro Asn Gly Phe Pro Gly Pro Lys Gly Pro Pro Gly Pro 
                885                 890                 895     


Pro Gly Lys Asp Gly Leu Pro Gly His Pro Gly Gln Arg Gly Glu Val 
            900                 905                 910         


Gly Phe Gln Gly Lys Thr Gly Pro Pro Gly Pro Pro Gly Val Val Gly 
        915                 920                 925             


Pro Gln Gly Ala Ala Gly Glu Thr Gly Pro Met Gly Glu Arg Gly His 
    930                 935                 940                 


Pro Gly Pro Pro Gly Pro Pro Gly Glu Gln Gly Leu Pro Gly Thr Ala 
945                 950                 955                 960 


Gly Lys Glu Gly Thr Lys Gly Asp Pro Gly Pro Pro Gly Ala Pro Gly 
                965                 970                 975     


Lys Asp Gly Pro Ala Gly Leu Arg Gly Phe Pro Gly Glu Arg Gly Leu 
            980                 985                 990         


Pro Gly Thr Ala Gly Gly Pro Gly  Leu Lys Gly Asn Glu  Gly Pro Ser 
        995                 1000                 1005             


Gly Pro  Pro Gly Pro Ala Gly  Ser Pro Gly Glu Arg  Gly Ala Ala 
    1010                 1015                 1020             


Gly Ser  Gly Gly Pro Ile Gly  Pro Pro Gly Arg Pro  Gly Pro Gln 
    1025                 1030                 1035             


Gly Pro  Pro Gly Ala Ala Gly  Glu Lys Gly Val Pro  Gly Glu Lys 
    1040                 1045                 1050             


Gly Pro  Ile Gly Pro Thr Gly  Arg Asp Gly Val Gln  Gly Pro Val 
    1055                 1060                 1065             


Gly Leu  Pro Gly Pro Ala Gly  Pro Pro Gly Val Ala  Gly Glu Asp 
    1070                 1075                 1080             


Gly Asp  Lys Gly Glu Val Gly  Asp Pro Gly Gln Lys  Gly Thr Lys 
    1085                 1090                 1095             


Gly Asn  Lys Gly Glu His Gly  Pro Pro Gly Pro Pro  Gly Pro Ile 
    1100                 1105                 1110             


Gly Pro  Val Gly Gln Pro Gly  Ala Ala Gly Ala Asp  Gly Glu Pro 
    1115                 1120                 1125             


Gly Ala  Arg Gly Pro Gln Gly  His Phe Gly Ala Lys  Gly Asp Glu 
    1130                 1135                 1140             


Gly Thr  Arg Gly Phe Asn Gly  Pro Pro Gly Pro Ile  Gly Leu Gln 
    1145                 1150                 1155             


Gly Leu  Pro Gly Pro Ser Gly  Glu Lys Gly Glu Thr  Gly Asp Val 
    1160                 1165                 1170             


Gly Pro  Met Gly Pro Pro Gly  Pro Pro Gly Pro Arg  Gly Pro Ala 
    1175                 1180                 1185             


Gly Pro  Asn Gly Ala Asp Gly  Pro Gln Gly Pro Pro  Gly Gly Val 
    1190                 1195                 1200             


Gly Asn  Leu Gly Pro Pro Gly  Glu Lys Gly Glu Pro  Gly Glu Ser 
    1205                 1210                 1215             


Gly Ser  Pro Gly Ile Gln Gly  Glu Pro Gly Val Lys  Gly Pro Arg 
    1220                 1225                 1230             


Gly Glu  Arg Gly Glu Lys Gly  Glu Ser Gly Gln Pro  Gly Glu Pro 
    1235                 1240                 1245             


Gly Pro  Pro Gly Pro Lys Gly  Pro Thr Gly Asp Asp  Gly Pro Lys 
    1250                 1255                 1260             


Gly Asn  Pro Gly Pro Val Gly  Phe Pro Gly Asp Pro  Gly Pro Pro 
    1265                 1270                 1275             


Gly Glu  Gly Gly Pro Arg Gly  Gln Asp Gly Ala Lys  Gly Asp Arg 
    1280                 1285                 1290             


Gly Glu  Asp Gly Glu Pro Gly  Gln Pro Gly Ser Pro  Gly Pro Thr 
    1295                 1300                 1305             


Gly Glu  Asn Gly Pro Pro Gly  Pro Leu Gly Lys Arg  Gly Pro Ala 
    1310                 1315                 1320             


Gly Ser  Pro Gly Ser Glu Gly  Arg Gln Gly Gly Lys  Gly Ala Lys 
    1325                 1330                 1335             


Gly Asp  Pro Gly Ala Ile Gly  Ala Pro Gly Lys Thr  Gly Pro Val 
    1340                 1345                 1350             


Gly Pro  Ala Gly Pro Ala Gly  Lys Pro Gly Pro Asp  Gly Leu Arg 
    1355                 1360                 1365             


Gly Leu  Pro Gly Ser Val Gly  Gln Gln Gly Arg Pro  Gly Ala Thr 
    1370                 1375                 1380             


Gly Gln  Ala Gly Pro Pro Gly  Pro Val Gly Pro Pro  Gly Leu Pro 
    1385                 1390                 1395             


Gly Leu  Arg Gly Asp Ala Gly  Ala Lys Gly Glu Lys  Gly His Pro 
    1400                 1405                 1410             


Gly Leu  Ile Gly Leu Ile Gly  Pro Pro Gly Glu Gln  Gly Glu Lys 
    1415                 1420                 1425             


Gly Asp  Arg Gly Leu Pro Gly  Pro Gln Gly Ser Pro  Gly Gln Lys 
    1430                 1435                 1440             


Gly Glu  Met Gly Ile Pro Gly  Ala Ser Gly Pro Ile  Gly Pro Gly 
    1445                 1450                 1455             


Gly Pro  Pro Gly Leu Pro Gly  Pro Ala Gly Pro Lys  Gly Ala Lys 
    1460                 1465                 1470             


Gly Ala  Thr Gly Pro Gly Gly  Pro Lys Gly Glu Lys  Gly Val Gln 
    1475                 1480                 1485             


Gly Pro  Pro Gly His Pro Gly  Pro Pro Gly Glu Val  Ile Gln Pro 
    1490                 1495                 1500             


Leu Pro  Ile Gln Met Pro Lys  Lys Thr Arg Arg Ser  Val Asp Gly 
    1505                 1510                 1515             


Ser Arg  Leu Met Gln Glu Asp  Glu Ala Ile Pro Thr  Gly Gly Ala 
    1520                 1525                 1530             


Pro Gly  Ser Pro Gly Gly Leu  Glu Glu Ile Phe Gly  Ser Leu Asp 
    1535                 1540                 1545             


Ser Leu  Arg Glu Glu Ile Glu  Gln Met Arg Arg Pro  Thr Gly Thr 
    1550                 1555                 1560             


Gln Asp  Ser Pro Ala Arg Thr  Cys Gln Asp Leu Lys  Leu Cys His 
    1565                 1570                 1575             


Pro Glu  Leu Pro Asp Gly Glu  Tyr Trp Val Asp Pro  Asn Gln Gly 
    1580                 1585                 1590             


Cys Ala  Arg Asp Ala Phe Arg  Val Phe Cys Asn Phe  Thr Ala Gly 
    1595                 1600                 1605             


Gly Glu  Thr Cys Val Thr Pro  Arg Asp Asp Val Thr  Gln Phe Ser 
    1610                 1615                 1620             


Tyr Val  Asp Ser Glu Gly Ser  Pro Val Gly Val Val  Gln Leu Thr 
    1625                 1630                 1635             


Phe Leu  Arg Leu Leu Ser Val  Ser Ala His Gln Asp  Val Ser Tyr 
    1640                 1645                 1650             


Pro Cys  Ser Gly Ala Ala Arg  Asp Gly Pro Leu Arg  Leu Arg Gly 
    1655                 1660                 1665             


Ala Asn  Glu Asp Glu Leu Ser  Pro Glu Thr Ser Pro  Tyr Val Lys 
    1670                 1675                 1680             


Glu Phe  Arg Asp Gly Cys Gln  Thr Gln Gln Gly Arg  Thr Val Leu 
    1685                 1690                 1695             


Glu Val  Arg Thr Pro Val Leu  Glu Gln Leu Pro Val  Leu Asp Ala 
    1700                 1705                 1710             


Ser Phe  Ser Asp Leu Gly Ala  Pro Pro Arg Arg Gly  Gly Val Leu 
    1715                 1720                 1725             


Leu Gly  Pro Val Cys Phe Met  Gly 
    1730                 1735     


<210>  5619
<211>  1650
<212>  PRT
<213>  Homo sapiens

<400>  5619

Met Glu Arg Cys Ser Arg Cys His Arg Leu Leu Leu Leu Leu Pro Leu 
1               5                   10                  15      


Val Leu Gly Leu Ser Ala Ala Pro Gly Trp Ala Gly Ala Pro Pro Val 
            20                  25                  30          


Asp Val Leu Arg Ala Leu Arg Phe Pro Ser Leu Pro Asp Gly Val Arg 
        35                  40                  45              


Arg Ala Lys Gly Ile Cys Pro Ala Asp Val Ala Tyr Arg Val Ala Arg 
    50                  55                  60                  


Pro Ala Gln Leu Ser Ala Pro Thr Arg Gln Leu Phe Pro Gly Gly Phe 
65                  70                  75                  80  


Pro Lys Asp Phe Ser Leu Leu Thr Val Val Arg Thr Arg Pro Gly Leu 
                85                  90                  95      


Gln Ala Pro Leu Leu Thr Leu Tyr Ser Ala Gln Gly Val Arg Gln Leu 
            100                 105                 110         


Gly Leu Glu Leu Gly Arg Pro Val Arg Phe Leu Tyr Glu Asp Gln Thr 
        115                 120                 125             


Gly Arg Pro Gln Pro Pro Ser Gln Pro Val Phe Arg Gly Leu Ser Leu 
    130                 135                 140                 


Ala Asp Gly Lys Trp His Arg Val Ala Val Ala Val Lys Gly Gln Ser 
145                 150                 155                 160 


Val Thr Leu Ile Val Asp Cys Lys Lys Arg Val Thr Arg Pro Leu Pro 
                165                 170                 175     


Arg Ser Ala Arg Pro Val Leu Asp Thr His Gly Val Ile Ile Phe Gly 
            180                 185                 190         


Ala Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Val Gln Glu Leu 
        195                 200                 205             


Ala Ile Val Pro Gly Val Gln Ala Ala Tyr Glu Ser Cys Glu Gln Lys 
    210                 215                 220                 


Glu Leu Glu Cys Glu Gly Gly Gln Arg Glu Arg Pro Gln Asn Gln Gln 
225                 230                 235                 240 


Pro His Arg Ala Gln Arg Ser Pro Gln Gln Gln Pro Ser Arg Leu His 
                245                 250                 255     


Arg Pro Gln Asn Gln Glu Pro Gln Ser Gln Asp Pro Thr Pro Gly Glu 
            260                 265                 270         


Glu Glu Glu Ile Leu Glu Ser Ser Leu Leu Pro Pro Leu Glu Glu Ala 
        275                 280                 285             


Ala His Gly Pro Arg Gly Leu Lys Gly Glu Lys Gly Glu Pro Ala Val 
    290                 295                 300                 


Leu Glu Pro Gly Met Leu Val Glu Gly Pro Pro Gly Pro Glu Gly Pro 
305                 310                 315                 320 


Ala Gly Leu Ile Gly Pro Pro Gly Ile Gln Gly Asn Pro Gly Pro Val 
                325                 330                 335     


Gly Asp Pro Gly Glu Arg Gly Pro Pro Gly Arg Ala Gly Leu Pro Gly 
            340                 345                 350         


Ser Asp Gly Ala Pro Gly Pro Pro Gly Thr Ser Leu Met Leu Pro Phe 
        355                 360                 365             


Arg Phe Gly Ser Gly Gly Gly Asp Lys Gly Pro Val Val Ala Ala Gln 
    370                 375                 380                 


Glu Ala Gln Ala Gln Ala Ile Leu Gln Gln Ala Arg Leu Ala Leu Arg 
385                 390                 395                 400 


Gly Pro Pro Gly Pro Met Gly Tyr Thr Gly Arg Pro Gly Pro Leu Gly 
                405                 410                 415     


Gln Pro Gly Ser Pro Gly Leu Lys Gly Glu Ser Gly Asp Leu Gly Pro 
            420                 425                 430         


Gln Gly Pro Arg Gly Pro Gln Gly Leu Thr Gly Pro Pro Gly Lys Ala 
        435                 440                 445             


Gly Arg Arg Gly Arg Ala Gly Ala Asp Gly Ala Arg Gly Met Pro Gly 
    450                 455                 460                 


Asp Pro Gly Val Lys Gly Asp Arg Gly Phe Asp Gly Leu Pro Gly Leu 
465                 470                 475                 480 


Pro Gly Glu Lys Gly His Arg Gly Asp Thr Gly Ala Gln Gly Leu Pro 
                485                 490                 495     


Gly Pro Pro Gly Glu Asp Gly Glu Arg Gly Asp Asp Gly Glu Ile Gly 
            500                 505                 510         


Pro Arg Gly Leu Pro Gly Glu Ser Gly Pro Arg Gly Leu Leu Gly Pro 
        515                 520                 525             


Lys Gly Pro Pro Gly Ile Pro Gly Pro Pro Gly Val Arg Gly Met Asp 
    530                 535                 540                 


Gly Pro Gln Gly Pro Lys Gly Ser Leu Gly Pro Gln Gly Glu Pro Gly 
545                 550                 555                 560 


Pro Pro Gly Gln Gln Gly Thr Pro Gly Thr Gln Gly Leu Pro Gly Pro 
                565                 570                 575     


Gln Gly Ala Ile Gly Pro His Gly Glu Lys Gly Pro Gln Gly Lys Pro 
            580                 585                 590         


Gly Leu Pro Gly Met Pro Gly Ser Asp Gly Pro Pro Gly His Pro Gly 
        595                 600                 605             


Lys Glu Gly Pro Pro Gly Thr Lys Gly Asn Gln Gly Pro Ser Gly Pro 
    610                 615                 620                 


Gln Gly Pro Leu Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Val Asp 
625                 630                 635                 640 


Gly Ile Arg Gly Leu Lys Gly His Lys Gly Glu Lys Gly Glu Asp Gly 
                645                 650                 655     


Phe Pro Gly Phe Lys Gly Asp Ile Gly Val Lys Gly Asp Arg Gly Glu 
            660                 665                 670         


Val Gly Val Pro Gly Ser Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys 
        675                 680                 685             


Gly Arg Thr Gly Pro Thr Gly Asp Pro Gly Pro Pro Gly Leu Met Gly 
    690                 695                 700                 


Glu Lys Gly Lys Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg 
705                 710                 715                 720 


Gln Gly Pro Lys Gly Ser Leu Gly Phe Pro Gly Phe Pro Gly Ala Ser 
                725                 730                 735     


Gly Glu Lys Gly Ala Arg Gly Leu Ser Gly Lys Ser Gly Pro Arg Gly 
            740                 745                 750         


Glu Arg Gly Pro Thr Gly Pro Arg Gly Gln Arg Gly Pro Arg Gly Ala 
        755                 760                 765             


Thr Gly Lys Ser Gly Ala Lys Gly Thr Ser Gly Gly Asp Gly Pro His 
    770                 775                 780                 


Gly Pro Pro Gly Glu Arg Gly Leu Pro Gly Pro Gln Gly Pro Asn Gly 
785                 790                 795                 800 


Phe Pro Gly Pro Lys Gly Pro Pro Gly Pro Pro Gly Lys Asp Gly Leu 
                805                 810                 815     


Pro Gly His Pro Gly Gln Arg Gly Glu Val Gly Phe Gln Gly Lys Thr 
            820                 825                 830         


Gly Pro Pro Gly Pro Pro Gly Val Val Gly Pro Gln Gly Ala Ala Gly 
        835                 840                 845             


Glu Thr Gly Pro Met Gly Glu Arg Gly His Pro Gly Pro Pro Gly Pro 
    850                 855                 860                 


Pro Gly Glu Gln Gly Leu Pro Gly Thr Ala Gly Lys Glu Gly Thr Lys 
865                 870                 875                 880 


Gly Asp Pro Gly Pro Pro Gly Ala Pro Gly Lys Asp Gly Pro Ala Gly 
                885                 890                 895     


Leu Arg Gly Phe Pro Gly Glu Arg Gly Leu Pro Gly Thr Ala Gly Gly 
            900                 905                 910         


Pro Gly Leu Lys Gly Asn Glu Gly Pro Ser Gly Pro Pro Gly Pro Ala 
        915                 920                 925             


Gly Ser Pro Gly Glu Arg Gly Ala Ala Gly Ser Gly Gly Pro Ile Gly 
    930                 935                 940                 


Pro Pro Gly Arg Pro Gly Pro Gln Gly Pro Pro Gly Ala Ala Gly Glu 
945                 950                 955                 960 


Lys Gly Val Pro Gly Glu Lys Gly Pro Ile Gly Pro Thr Gly Arg Asp 
                965                 970                 975     


Gly Val Gln Gly Pro Val Gly Leu Pro Gly Pro Ala Gly Pro Pro Gly 
            980                 985                 990         


Val Ala Gly Glu Asp Gly Asp Lys  Gly Glu Val Gly Asp  Pro Gly Gln 
        995                 1000                 1005             


Lys Gly  Thr Lys Gly Asn Lys  Gly Glu His Gly Pro  Pro Gly Pro 
    1010                 1015                 1020             


Pro Gly  Pro Ile Gly Pro Val  Gly Gln Pro Gly Ala  Ala Gly Ala 
    1025                 1030                 1035             


Asp Gly  Glu Pro Gly Ala Arg  Gly Pro Gln Gly His  Phe Gly Ala 
    1040                 1045                 1050             


Lys Gly  Asp Glu Gly Thr Arg  Gly Phe Asn Gly Pro  Pro Gly Pro 
    1055                 1060                 1065             


Ile Gly  Leu Gln Gly Leu Pro  Gly Pro Ser Gly Glu  Lys Gly Glu 
    1070                 1075                 1080             


Thr Gly  Asp Val Gly Pro Met  Gly Pro Pro Gly Pro  Pro Gly Pro 
    1085                 1090                 1095             


Arg Gly  Pro Ala Gly Pro Asn  Gly Ala Asp Gly Pro  Gln Gly Pro 
    1100                 1105                 1110             


Pro Gly  Gly Val Gly Asn Leu  Gly Pro Pro Gly Glu  Lys Gly Glu 
    1115                 1120                 1125             


Pro Gly  Glu Ser Gly Ser Pro  Gly Ile Gln Gly Glu  Pro Gly Val 
    1130                 1135                 1140             


Lys Gly  Pro Arg Gly Glu Arg  Gly Glu Lys Gly Glu  Ser Gly Gln 
    1145                 1150                 1155             


Pro Gly  Glu Pro Gly Pro Pro  Gly Pro Lys Gly Pro  Thr Gly Asp 
    1160                 1165                 1170             


Asp Gly  Pro Lys Gly Asn Pro  Gly Pro Val Gly Phe  Pro Gly Asp 
    1175                 1180                 1185             


Pro Gly  Pro Pro Gly Glu Gly  Gly Pro Arg Gly Gln  Asp Gly Ala 
    1190                 1195                 1200             


Lys Gly  Asp Arg Gly Glu Asp  Gly Glu Pro Gly Gln  Pro Gly Ser 
    1205                 1210                 1215             


Pro Gly  Pro Thr Gly Glu Asn  Gly Pro Pro Gly Pro  Leu Gly Lys 
    1220                 1225                 1230             


Arg Gly  Pro Ala Gly Ser Pro  Gly Ser Glu Gly Arg  Gln Gly Gly 
    1235                 1240                 1245             


Lys Gly  Ala Lys Gly Asp Pro  Gly Ala Ile Gly Ala  Pro Gly Lys 
    1250                 1255                 1260             


Thr Gly  Pro Val Gly Pro Ala  Gly Pro Ala Gly Lys  Pro Gly Pro 
    1265                 1270                 1275             


Asp Gly  Leu Arg Gly Leu Pro  Gly Ser Val Gly Gln  Gln Gly Arg 
    1280                 1285                 1290             


Pro Gly  Ala Thr Gly Gln Ala  Gly Pro Pro Gly Pro  Val Gly Pro 
    1295                 1300                 1305             


Pro Gly  Leu Pro Gly Leu Arg  Gly Asp Ala Gly Ala  Lys Gly Glu 
    1310                 1315                 1320             


Lys Gly  His Pro Gly Leu Ile  Gly Leu Ile Gly Pro  Pro Gly Glu 
    1325                 1330                 1335             


Gln Gly  Glu Lys Gly Asp Arg  Gly Leu Pro Gly Pro  Gln Gly Ser 
    1340                 1345                 1350             


Pro Gly  Gln Lys Gly Glu Met  Gly Ile Pro Gly Ala  Ser Gly Pro 
    1355                 1360                 1365             


Ile Gly  Pro Gly Gly Pro Pro  Gly Leu Pro Gly Pro  Ala Gly Pro 
    1370                 1375                 1380             


Lys Gly  Ala Lys Gly Ala Thr  Gly Pro Gly Gly Pro  Lys Gly Glu 
    1385                 1390                 1395             


Lys Gly  Val Gln Gly Pro Pro  Gly His Pro Gly Pro  Pro Gly Glu 
    1400                 1405                 1410             


Val Ile  Gln Pro Leu Pro Ile  Gln Met Pro Lys Lys  Thr Arg Arg 
    1415                 1420                 1425             


Ser Val  Asp Gly Ser Arg Leu  Met Gln Glu Asp Glu  Ala Ile Pro 
    1430                 1435                 1440             


Thr Gly  Gly Ala Pro Gly Ser  Pro Gly Gly Leu Glu  Glu Ile Phe 
    1445                 1450                 1455             


Gly Ser  Leu Asp Ser Leu Arg  Glu Glu Ile Glu Gln  Met Arg Arg 
    1460                 1465                 1470             


Pro Thr  Gly Thr Gln Asp Ser  Pro Ala Arg Thr Cys  Gln Asp Leu 
    1475                 1480                 1485             


Lys Leu  Cys His Pro Glu Leu  Pro Asp Gly Glu Tyr  Trp Val Asp 
    1490                 1495                 1500             


Pro Asn  Gln Gly Cys Ala Arg  Asp Ala Phe Arg Val  Phe Cys Asn 
    1505                 1510                 1515             


Phe Thr  Ala Gly Gly Glu Thr  Cys Val Thr Pro Arg  Asp Asp Val 
    1520                 1525                 1530             


Thr Gln  Phe Ser Tyr Val Asp  Ser Glu Gly Ser Pro  Val Gly Val 
    1535                 1540                 1545             


Val Gln  Leu Thr Phe Leu Arg  Leu Leu Ser Val Ser  Ala His Gln 
    1550                 1555                 1560             


Asp Val  Ser Tyr Pro Cys Ser  Gly Ala Ala Arg Asp  Gly Pro Leu 
    1565                 1570                 1575             


Arg Leu  Arg Gly Ala Asn Glu  Asp Glu Leu Ser Pro  Glu Thr Ser 
    1580                 1585                 1590             


Pro Tyr  Val Lys Glu Phe Arg  Asp Gly Cys Gln Thr  Gln Gln Gly 
    1595                 1600                 1605             


Arg Thr  Val Leu Glu Val Arg  Thr Pro Val Leu Glu  Gln Leu Pro 
    1610                 1615                 1620             


Val Leu  Asp Ala Ser Phe Ser  Asp Leu Gly Ala Pro  Pro Arg Arg 
    1625                 1630                 1635             


Gly Gly  Val Leu Leu Gly Pro  Val Cys Phe Met Gly  
    1640                 1645                 1650 


<210>  5620
<211>  647
<212>  PRT
<213>  Homo sapiens

<400>  5620

Met Pro Gly Lys Met Val Val Ile Leu Gly Ala Ser Asn Ile Leu Trp 
1               5                   10                  15      


Ile Met Phe Ala Ala Ser Gln Ala Phe Lys Ile Glu Thr Thr Pro Glu 
            20                  25                  30          


Ser Arg Tyr Leu Ala Gln Ile Gly Asp Ser Val Ser Leu Thr Cys Ser 
        35                  40                  45              


Thr Thr Gly Cys Glu Ser Pro Phe Phe Ser Trp Arg Thr Gln Ile Asp 
    50                  55                  60                  


Ser Pro Leu Asn Gly Lys Val Thr Asn Glu Gly Thr Thr Ser Thr Leu 
65                  70                  75                  80  


Thr Met Asn Pro Val Ser Phe Gly Asn Glu His Ser Tyr Leu Cys Thr 
                85                  90                  95      


Ala Thr Cys Glu Ser Arg Lys Leu Glu Lys Gly Ile Gln Val Glu Ile 
            100                 105                 110         


Tyr Ser Phe Pro Lys Asp Pro Glu Ile His Leu Ser Gly Pro Leu Glu 
        115                 120                 125             


Ala Gly Lys Pro Ile Thr Val Lys Cys Ser Val Ala Asp Val Tyr Pro 
    130                 135                 140                 


Phe Asp Arg Leu Glu Ile Asp Leu Leu Lys Gly Asp His Leu Met Lys 
145                 150                 155                 160 


Ser Gln Glu Phe Leu Glu Asp Ala Asp Arg Lys Ser Leu Glu Thr Lys 
                165                 170                 175     


Ser Leu Glu Val Thr Phe Thr Pro Val Ile Glu Asp Ile Gly Lys Val 
            180                 185                 190         


Leu Val Cys Arg Ala Lys Leu His Ile Asp Glu Met Asp Ser Val Pro 
        195                 200                 205             


Thr Val Arg Gln Ala Val Lys Glu Leu Gln Val Tyr Ile Ser Pro Lys 
    210                 215                 220                 


Asn Thr Val Ile Ser Val Asn Pro Ser Thr Lys Leu Gln Glu Gly Gly 
225                 230                 235                 240 


Ser Val Thr Met Thr Cys Ser Ser Glu Gly Leu Pro Ala Pro Glu Ile 
                245                 250                 255     


Phe Trp Ser Lys Lys Leu Asp Asn Gly Asn Leu Gln His Leu Ser Gly 
            260                 265                 270         


Asn Ala Thr Leu Thr Leu Ile Ala Met Arg Met Glu Asp Ser Gly Ile 
        275                 280                 285             


Tyr Val Cys Glu Gly Val Asn Leu Ile Gly Lys Asn Arg Lys Glu Val 
    290                 295                 300                 


Glu Leu Ile Val Gln Ala Phe Pro Arg Asp Pro Glu Ile Glu Met Ser 
305                 310                 315                 320 


Gly Gly Leu Val Asn Gly Ser Ser Val Thr Val Ser Cys Lys Val Pro 
                325                 330                 335     


Ser Val Tyr Pro Leu Asp Arg Leu Glu Ile Glu Leu Leu Lys Gly Glu 
            340                 345                 350         


Thr Ile Leu Glu Asn Ile Glu Phe Leu Glu Asp Thr Asp Met Lys Ser 
        355                 360                 365             


Leu Glu Asn Lys Ser Leu Glu Met Thr Phe Ile Pro Thr Ile Glu Asp 
    370                 375                 380                 


Thr Gly Lys Ala Leu Val Cys Gln Ala Lys Leu His Ile Asp Asp Met 
385                 390                 395                 400 


Glu Phe Glu Pro Lys Gln Arg Gln Ser Thr Gln Thr Leu Tyr Val Asn 
                405                 410                 415     


Val Ala Pro Arg Asp Thr Thr Val Leu Val Ser Pro Ser Ser Ile Leu 
            420                 425                 430         


Glu Glu Gly Ser Ser Val Asn Met Thr Cys Leu Ser Gln Gly Phe Pro 
        435                 440                 445             


Ala Pro Lys Ile Leu Trp Ser Arg Gln Leu Pro Asn Gly Glu Leu Gln 
    450                 455                 460                 


Pro Leu Ser Glu Asn Ala Thr Leu Thr Leu Ile Ser Thr Lys Met Glu 
465                 470                 475                 480 


Asp Ser Gly Val Tyr Leu Cys Glu Gly Ile Asn Gln Ala Gly Arg Ser 
                485                 490                 495     


Arg Lys Glu Val Glu Leu Ile Ile Gln Val Thr Pro Lys Asp Ile Lys 
            500                 505                 510         


Leu Thr Ala Phe Pro Ser Glu Ser Val Lys Glu Gly Asp Thr Val Ile 
        515                 520                 525             


Ile Ser Cys Thr Cys Gly Asn Val Pro Glu Thr Trp Ile Ile Leu Lys 
    530                 535                 540                 


Lys Lys Ala Glu Thr Gly Asp Thr Val Leu Lys Ser Ile Asp Gly Ala 
545                 550                 555                 560 


Tyr Thr Ile Arg Lys Ala Gln Leu Lys Asp Ala Gly Val Tyr Glu Cys 
                565                 570                 575     


Glu Ser Lys Asn Lys Val Gly Ser Gln Leu Arg Ser Leu Thr Leu Asp 
            580                 585                 590         


Val Gln Gly Arg Glu Asn Asn Lys Asp Tyr Phe Ser Pro Glu Leu Leu 
        595                 600                 605             


Val Leu Tyr Phe Ala Ser Ser Leu Ile Ile Pro Ala Ile Gly Met Ile 
    610                 615                 620                 


Ile Tyr Phe Ala Arg Lys Ala Asn Met Lys Gly Ser Tyr Ser Leu Val 
625                 630                 635                 640 


Glu Ala Gln Lys Ser Lys Val 
                645         


<210>  5621
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  5621

Met Lys Lys Trp Ser Ser Thr Asp Leu Gly Ala Ala Ala Asp Pro Leu 
1               5                   10                  15      


Gln Lys Asp Thr Cys Pro Asp Pro Leu Asp Gly Asp Pro Asn Ser Arg 
            20                  25                  30          


Pro Pro Pro Ala Lys Pro Gln Leu Ser Thr Ala Lys Ser Arg Thr Arg 
        35                  40                  45              


Leu Phe Gly Lys Gly Asp Ser Glu Glu Ala Phe Pro Val Asp Cys Pro 
    50                  55                  60                  


His Glu Glu Gly Glu Leu Asp Ser Cys Pro Thr Ile Thr Val Ser Pro 
65                  70                  75                  80  


Val Ile Thr Ile Gln Arg Pro Gly Asp Gly Pro Thr Gly Ala Arg Leu 
                85                  90                  95      


Leu Ser Gln Asp Ser Val Ala Ala Ser Thr Glu Lys Thr Leu Arg Leu 
            100                 105                 110         


Tyr Asp Arg Arg Ser Ile Phe Glu Ala Val Ala Gln Asn Asn Cys Gln 
        115                 120                 125             


Asp Leu Glu Ser Leu Leu Leu Phe Leu Gln Lys Ser Lys Lys His Leu 
    130                 135                 140                 


Thr Asp Asn Glu Phe Lys Asp Pro Glu Thr Gly Lys Thr Cys Leu Leu 
145                 150                 155                 160 


Lys Ala Met Leu Asn Leu His Asp Gly Gln Asn Thr Thr Ile Pro Leu 
                165                 170                 175     


Leu Leu Glu Ile Ala Arg Gln Thr Asp Ser Leu Lys Glu Leu Val Asn 
            180                 185                 190         


Ala Ser Tyr Thr Asp Ser Tyr Tyr Lys Gly Gln Thr Ala Leu His Ile 
        195                 200                 205             


Ala Ile Glu Arg Arg Asn Met Ala Leu Val Thr Leu Leu Val Glu Asn 
    210                 215                 220                 


Gly Ala Asp Val Gln Ala Ala Ala His Gly Asp Phe Phe Lys Lys Thr 
225                 230                 235                 240 


Lys Gly Arg Pro Gly Phe Tyr Phe Gly Glu Leu Pro Leu Ser Leu Ala 
                245                 250                 255     


Ala Cys Thr Asn Gln Leu Gly Ile Val Lys Phe Leu Leu Gln Asn Ser 
            260                 265                 270         


Trp Gln Thr Ala Asp Ile Ser Ala Arg Asp Ser Val Gly Asn Thr Val 
        275                 280                 285             


Leu His Ala Leu Val Glu Val Ala Asp Asn Thr Ala Asp Asn Thr Lys 
    290                 295                 300                 


Phe Val Thr Ser Met Tyr Asn Glu Ile Leu Met Leu Gly Ala Lys Leu 
305                 310                 315                 320 


His Pro Thr Leu Lys Leu Glu Glu Leu Thr Asn Lys Lys Gly Met Thr 
                325                 330                 335     


Pro Leu Ala Leu Ala Ala Gly Thr Gly Lys Ile Gly Val Leu Ala Tyr 
            340                 345                 350         


Ile Leu Gln Arg Glu Ile Gln Glu Pro Glu Cys Arg His Leu Ser Arg 
        355                 360                 365             


Lys Phe Thr Glu Trp Ala Tyr Gly Pro Val His Ser Ser Leu Tyr Asp 
    370                 375                 380                 


Leu Ser Cys Ile Asp Thr Cys Glu Lys Asn Ser Val Leu Glu Val Ile 
385                 390                 395                 400 


Ala Tyr Ser Ser Ser Glu Thr Pro Asn Arg His Asp Met Leu Leu Val 
                405                 410                 415     


Glu Pro Leu Asn Arg Leu Leu Gln Asp Lys Trp Asp Arg Phe Val Lys 
            420                 425                 430         


Arg Ile Phe Tyr Phe Asn Phe Leu Val Tyr Cys Leu Tyr Met Ile Ile 
        435                 440                 445             


Phe Thr Met Ala Ala Tyr Tyr Arg Pro Val Asp Gly Leu Pro Pro Phe 
    450                 455                 460                 


Lys Met Glu Lys Thr Gly Asp Tyr Phe Arg Val Thr Gly Glu Ile Leu 
465                 470                 475                 480 


Ser Val Leu Gly Gly Val Tyr Phe Phe Phe Arg Gly Ile Gln Tyr Phe 
                485                 490                 495     


Leu Gln Arg Arg Pro Ser Met Lys Thr Leu Phe Val Asp Ser Tyr Ser 
            500                 505                 510         


Glu Met Leu Phe Phe Leu Gln Ser Leu Phe Met Leu Ala Thr Val Val 
        515                 520                 525             


Leu Tyr Phe Ser His Leu Lys Glu Tyr Val Ala Ser Met Val Phe Ser 
    530                 535                 540                 


Leu Ala Leu Gly Trp Thr Asn Met Leu Tyr Tyr Thr Arg Gly Phe Gln 
545                 550                 555                 560 


Gln Met Gly Ile Tyr Ala Val Met Ile Glu Lys Met Ile Leu Arg Asp 
                565                 570                 575     


Leu Cys Arg Phe Met Phe Val Tyr Ile Val Phe Leu Phe Gly Phe Ser 
            580                 585                 590         


Thr Ala Val Val Thr Leu Ile Glu Asp Gly Lys Asn Asp Ser Leu Pro 
        595                 600                 605             


Ser Glu Ser Thr Ser His Arg Trp Arg Gly Pro Ala Cys Arg Pro Pro 
    610                 615                 620                 


Asp Ser Ser Tyr Asn Ser Leu Tyr Ser Thr Cys Leu Glu Leu Phe Lys 
625                 630                 635                 640 


Phe Thr Ile Gly Met Gly Asp Leu Glu Phe Thr Glu Asn Tyr Asp Phe 
                645                 650                 655     


Lys Ala Val Phe Ile Ile Leu Leu Leu Ala Tyr Val Ile Leu Thr Tyr 
            660                 665                 670         


Ile Leu Leu Leu Asn Met Leu Ile Ala Leu Met Gly Glu Thr Val Asn 
        675                 680                 685             


Lys Ile Ala Gln Glu Ser Lys Asn Ile Trp Lys Leu Gln Arg Ala Ile 
    690                 695                 700                 


Thr Ile Leu Asp Thr Glu Lys Ser Phe Leu Lys Cys Met Arg Lys Ala 
705                 710                 715                 720 


Phe Arg Ser Gly Lys Leu Leu Gln Val Gly Tyr Thr Pro Asp Gly Lys 
                725                 730                 735     


Asp Asp Tyr Arg Trp Cys Phe Arg Val Asp Glu Val Asn Trp Thr Thr 
            740                 745                 750         


Trp Asn Thr Asn Val Gly Ile Ile Asn Glu Asp Pro Gly Asn Cys Glu 
        755                 760                 765             


Gly Val Lys Arg Thr Leu Ser Phe Ser Leu Arg Ser Ser Arg Val Ser 
    770                 775                 780                 


Gly Arg His Trp Lys Asn Phe Ala Leu Val Pro Leu Leu Arg Glu Ala 
785                 790                 795                 800 


Ser Ala Arg Asp Arg Gln Ser Ala Gln Pro Glu Glu Val Tyr Leu Arg 
                805                 810                 815     


Gln Phe Ser Gly Ser Leu Lys Pro Glu Asp Ala Glu Val Phe Lys Ser 
            820                 825                 830         


Pro Ala Ala Ser Gly Glu Lys 
        835                 


<210>  5622
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  5622

Met Lys Lys Trp Ser Ser Thr Asp Leu Gly Ala Ala Ala Asp Pro Leu 
1               5                   10                  15      


Gln Lys Asp Thr Cys Pro Asp Pro Leu Asp Gly Asp Pro Asn Ser Arg 
            20                  25                  30          


Pro Pro Pro Ala Lys Pro Gln Leu Ser Thr Ala Lys Ser Arg Thr Arg 
        35                  40                  45              


Leu Phe Gly Lys Gly Asp Ser Glu Glu Ala Phe Pro Val Asp Cys Pro 
    50                  55                  60                  


His Glu Glu Gly Glu Leu Asp Ser Cys Pro Thr Ile Thr Val Ser Pro 
65                  70                  75                  80  


Val Ile Thr Ile Gln Arg Pro Gly Asp Gly Pro Thr Gly Ala Arg Leu 
                85                  90                  95      


Leu Ser Gln Asp Ser Val Ala Ala Ser Thr Glu Lys Thr Leu Arg Leu 
            100                 105                 110         


Tyr Asp Arg Arg Ser Ile Phe Glu Ala Val Ala Gln Asn Asn Cys Gln 
        115                 120                 125             


Asp Leu Glu Ser Leu Leu Leu Phe Leu Gln Lys Ser Lys Lys His Leu 
    130                 135                 140                 


Thr Asp Asn Glu Phe Lys Asp Pro Glu Thr Gly Lys Thr Cys Leu Leu 
145                 150                 155                 160 


Lys Ala Met Leu Asn Leu His Asp Gly Gln Asn Thr Thr Ile Pro Leu 
                165                 170                 175     


Leu Leu Glu Ile Ala Arg Gln Thr Asp Ser Leu Lys Glu Leu Val Asn 
            180                 185                 190         


Ala Ser Tyr Thr Asp Ser Tyr Tyr Lys Gly Gln Thr Ala Leu His Ile 
        195                 200                 205             


Ala Ile Glu Arg Arg Asn Met Ala Leu Val Thr Leu Leu Val Glu Asn 
    210                 215                 220                 


Gly Ala Asp Val Gln Ala Ala Ala His Gly Asp Phe Phe Lys Lys Thr 
225                 230                 235                 240 


Lys Gly Arg Pro Gly Phe Tyr Phe Gly Glu Leu Pro Leu Ser Leu Ala 
                245                 250                 255     


Ala Cys Thr Asn Gln Leu Gly Ile Val Lys Phe Leu Leu Gln Asn Ser 
            260                 265                 270         


Trp Gln Thr Ala Asp Ile Ser Ala Arg Asp Ser Val Gly Asn Thr Val 
        275                 280                 285             


Leu His Ala Leu Val Glu Val Ala Asp Asn Thr Ala Asp Asn Thr Lys 
    290                 295                 300                 


Phe Val Thr Ser Met Tyr Asn Glu Ile Leu Met Leu Gly Ala Lys Leu 
305                 310                 315                 320 


His Pro Thr Leu Lys Leu Glu Glu Leu Thr Asn Lys Lys Gly Met Thr 
                325                 330                 335     


Pro Leu Ala Leu Ala Ala Gly Thr Gly Lys Ile Gly Val Leu Ala Tyr 
            340                 345                 350         


Ile Leu Gln Arg Glu Ile Gln Glu Pro Glu Cys Arg His Leu Ser Arg 
        355                 360                 365             


Lys Phe Thr Glu Trp Ala Tyr Gly Pro Val His Ser Ser Leu Tyr Asp 
    370                 375                 380                 


Leu Ser Cys Ile Asp Thr Cys Glu Lys Asn Ser Val Leu Glu Val Ile 
385                 390                 395                 400 


Ala Tyr Ser Ser Ser Glu Thr Pro Asn Arg His Asp Met Leu Leu Val 
                405                 410                 415     


Glu Pro Leu Asn Arg Leu Leu Gln Asp Lys Trp Asp Arg Phe Val Lys 
            420                 425                 430         


Arg Ile Phe Tyr Phe Asn Phe Leu Val Tyr Cys Leu Tyr Met Ile Ile 
        435                 440                 445             


Phe Thr Met Ala Ala Tyr Tyr Arg Pro Val Asp Gly Leu Pro Pro Phe 
    450                 455                 460                 


Lys Met Glu Lys Thr Gly Asp Tyr Phe Arg Val Thr Gly Glu Ile Leu 
465                 470                 475                 480 


Ser Val Leu Gly Gly Val Tyr Phe Phe Phe Arg Gly Ile Gln Tyr Phe 
                485                 490                 495     


Leu Gln Arg Arg Pro Ser Met Lys Thr Leu Phe Val Asp Ser Tyr Ser 
            500                 505                 510         


Glu Met Leu Phe Phe Leu Gln Ser Leu Phe Met Leu Ala Thr Val Val 
        515                 520                 525             


Leu Tyr Phe Ser His Leu Lys Glu Tyr Val Ala Ser Met Val Phe Ser 
    530                 535                 540                 


Leu Ala Leu Gly Trp Thr Asn Met Leu Tyr Tyr Thr Arg Gly Phe Gln 
545                 550                 555                 560 


Gln Met Gly Ile Tyr Ala Val Met Ile Glu Lys Met Ile Leu Arg Asp 
                565                 570                 575     


Leu Cys Arg Phe Met Phe Val Tyr Ile Val Phe Leu Phe Gly Phe Ser 
            580                 585                 590         


Thr Ala Val Val Thr Leu Ile Glu Asp Gly Lys Asn Asp Ser Leu Pro 
        595                 600                 605             


Ser Glu Ser Thr Ser His Arg Trp Arg Gly Pro Ala Cys Arg Pro Pro 
    610                 615                 620                 


Asp Ser Ser Tyr Asn Ser Leu Tyr Ser Thr Cys Leu Glu Leu Phe Lys 
625                 630                 635                 640 


Phe Thr Ile Gly Met Gly Asp Leu Glu Phe Thr Glu Asn Tyr Asp Phe 
                645                 650                 655     


Lys Ala Val Phe Ile Ile Leu Leu Leu Ala Tyr Val Ile Leu Thr Tyr 
            660                 665                 670         


Ile Leu Leu Leu Asn Met Leu Ile Ala Leu Met Gly Glu Thr Val Asn 
        675                 680                 685             


Lys Ile Ala Gln Glu Ser Lys Asn Ile Trp Lys Leu Gln Arg Ala Ile 
    690                 695                 700                 


Thr Ile Leu Asp Thr Glu Lys Ser Phe Leu Lys Cys Met Arg Lys Ala 
705                 710                 715                 720 


Phe Arg Ser Gly Lys Leu Leu Gln Val Gly Tyr Thr Pro Asp Gly Lys 
                725                 730                 735     


Asp Asp Tyr Arg Trp Cys Phe Arg Val Asp Glu Val Asn Trp Thr Thr 
            740                 745                 750         


Trp Asn Thr Asn Val Gly Ile Ile Asn Glu Asp Pro Gly Asn Cys Glu 
        755                 760                 765             


Gly Val Lys Arg Thr Leu Ser Phe Ser Leu Arg Ser Ser Arg Val Ser 
    770                 775                 780                 


Gly Arg His Trp Lys Asn Phe Ala Leu Val Pro Leu Leu Arg Glu Ala 
785                 790                 795                 800 


Ser Ala Arg Asp Arg Gln Ser Ala Gln Pro Glu Glu Val Tyr Leu Arg 
                805                 810                 815     


Gln Phe Ser Gly Ser Leu Lys Pro Glu Asp Ala Glu Val Phe Lys Ser 
            820                 825                 830         


Pro Ala Ala Ser Gly Glu Lys 
        835                 


<210>  5623
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  5623

Met Lys Lys Trp Ser Ser Thr Asp Leu Gly Ala Ala Ala Asp Pro Leu 
1               5                   10                  15      


Gln Lys Asp Thr Cys Pro Asp Pro Leu Asp Gly Asp Pro Asn Ser Arg 
            20                  25                  30          


Pro Pro Pro Ala Lys Pro Gln Leu Ser Thr Ala Lys Ser Arg Thr Arg 
        35                  40                  45              


Leu Phe Gly Lys Gly Asp Ser Glu Glu Ala Phe Pro Val Asp Cys Pro 
    50                  55                  60                  


His Glu Glu Gly Glu Leu Asp Ser Cys Pro Thr Ile Thr Val Ser Pro 
65                  70                  75                  80  


Val Ile Thr Ile Gln Arg Pro Gly Asp Gly Pro Thr Gly Ala Arg Leu 
                85                  90                  95      


Leu Ser Gln Asp Ser Val Ala Ala Ser Thr Glu Lys Thr Leu Arg Leu 
            100                 105                 110         


Tyr Asp Arg Arg Ser Ile Phe Glu Ala Val Ala Gln Asn Asn Cys Gln 
        115                 120                 125             


Asp Leu Glu Ser Leu Leu Leu Phe Leu Gln Lys Ser Lys Lys His Leu 
    130                 135                 140                 


Thr Asp Asn Glu Phe Lys Asp Pro Glu Thr Gly Lys Thr Cys Leu Leu 
145                 150                 155                 160 


Lys Ala Met Leu Asn Leu His Asp Gly Gln Asn Thr Thr Ile Pro Leu 
                165                 170                 175     


Leu Leu Glu Ile Ala Arg Gln Thr Asp Ser Leu Lys Glu Leu Val Asn 
            180                 185                 190         


Ala Ser Tyr Thr Asp Ser Tyr Tyr Lys Gly Gln Thr Ala Leu His Ile 
        195                 200                 205             


Ala Ile Glu Arg Arg Asn Met Ala Leu Val Thr Leu Leu Val Glu Asn 
    210                 215                 220                 


Gly Ala Asp Val Gln Ala Ala Ala His Gly Asp Phe Phe Lys Lys Thr 
225                 230                 235                 240 


Lys Gly Arg Pro Gly Phe Tyr Phe Gly Glu Leu Pro Leu Ser Leu Ala 
                245                 250                 255     


Ala Cys Thr Asn Gln Leu Gly Ile Val Lys Phe Leu Leu Gln Asn Ser 
            260                 265                 270         


Trp Gln Thr Ala Asp Ile Ser Ala Arg Asp Ser Val Gly Asn Thr Val 
        275                 280                 285             


Leu His Ala Leu Val Glu Val Ala Asp Asn Thr Ala Asp Asn Thr Lys 
    290                 295                 300                 


Phe Val Thr Ser Met Tyr Asn Glu Ile Leu Met Leu Gly Ala Lys Leu 
305                 310                 315                 320 


His Pro Thr Leu Lys Leu Glu Glu Leu Thr Asn Lys Lys Gly Met Thr 
                325                 330                 335     


Pro Leu Ala Leu Ala Ala Gly Thr Gly Lys Ile Gly Val Leu Ala Tyr 
            340                 345                 350         


Ile Leu Gln Arg Glu Ile Gln Glu Pro Glu Cys Arg His Leu Ser Arg 
        355                 360                 365             


Lys Phe Thr Glu Trp Ala Tyr Gly Pro Val His Ser Ser Leu Tyr Asp 
    370                 375                 380                 


Leu Ser Cys Ile Asp Thr Cys Glu Lys Asn Ser Val Leu Glu Val Ile 
385                 390                 395                 400 


Ala Tyr Ser Ser Ser Glu Thr Pro Asn Arg His Asp Met Leu Leu Val 
                405                 410                 415     


Glu Pro Leu Asn Arg Leu Leu Gln Asp Lys Trp Asp Arg Phe Val Lys 
            420                 425                 430         


Arg Ile Phe Tyr Phe Asn Phe Leu Val Tyr Cys Leu Tyr Met Ile Ile 
        435                 440                 445             


Phe Thr Met Ala Ala Tyr Tyr Arg Pro Val Asp Gly Leu Pro Pro Phe 
    450                 455                 460                 


Lys Met Glu Lys Thr Gly Asp Tyr Phe Arg Val Thr Gly Glu Ile Leu 
465                 470                 475                 480 


Ser Val Leu Gly Gly Val Tyr Phe Phe Phe Arg Gly Ile Gln Tyr Phe 
                485                 490                 495     


Leu Gln Arg Arg Pro Ser Met Lys Thr Leu Phe Val Asp Ser Tyr Ser 
            500                 505                 510         


Glu Met Leu Phe Phe Leu Gln Ser Leu Phe Met Leu Ala Thr Val Val 
        515                 520                 525             


Leu Tyr Phe Ser His Leu Lys Glu Tyr Val Ala Ser Met Val Phe Ser 
    530                 535                 540                 


Leu Ala Leu Gly Trp Thr Asn Met Leu Tyr Tyr Thr Arg Gly Phe Gln 
545                 550                 555                 560 


Gln Met Gly Ile Tyr Ala Val Met Ile Glu Lys Met Ile Leu Arg Asp 
                565                 570                 575     


Leu Cys Arg Phe Met Phe Val Tyr Ile Val Phe Leu Phe Gly Phe Ser 
            580                 585                 590         


Thr Ala Val Val Thr Leu Ile Glu Asp Gly Lys Asn Asp Ser Leu Pro 
        595                 600                 605             


Ser Glu Ser Thr Ser His Arg Trp Arg Gly Pro Ala Cys Arg Pro Pro 
    610                 615                 620                 


Asp Ser Ser Tyr Asn Ser Leu Tyr Ser Thr Cys Leu Glu Leu Phe Lys 
625                 630                 635                 640 


Phe Thr Ile Gly Met Gly Asp Leu Glu Phe Thr Glu Asn Tyr Asp Phe 
                645                 650                 655     


Lys Ala Val Phe Ile Ile Leu Leu Leu Ala Tyr Val Ile Leu Thr Tyr 
            660                 665                 670         


Ile Leu Leu Leu Asn Met Leu Ile Ala Leu Met Gly Glu Thr Val Asn 
        675                 680                 685             


Lys Ile Ala Gln Glu Ser Lys Asn Ile Trp Lys Leu Gln Arg Ala Ile 
    690                 695                 700                 


Thr Ile Leu Asp Thr Glu Lys Ser Phe Leu Lys Cys Met Arg Lys Ala 
705                 710                 715                 720 


Phe Arg Ser Gly Lys Leu Leu Gln Val Gly Tyr Thr Pro Asp Gly Lys 
                725                 730                 735     


Asp Asp Tyr Arg Trp Cys Phe Arg Val Asp Glu Val Asn Trp Thr Thr 
            740                 745                 750         


Trp Asn Thr Asn Val Gly Ile Ile Asn Glu Asp Pro Gly Asn Cys Glu 
        755                 760                 765             


Gly Val Lys Arg Thr Leu Ser Phe Ser Leu Arg Ser Ser Arg Val Ser 
    770                 775                 780                 


Gly Arg His Trp Lys Asn Phe Ala Leu Val Pro Leu Leu Arg Glu Ala 
785                 790                 795                 800 


Ser Ala Arg Asp Arg Gln Ser Ala Gln Pro Glu Glu Val Tyr Leu Arg 
                805                 810                 815     


Gln Phe Ser Gly Ser Leu Lys Pro Glu Asp Ala Glu Val Phe Lys Ser 
            820                 825                 830         


Pro Ala Ala Ser Gly Glu Lys 
        835                 


<210>  5624
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  5624

Met Ser Ser Cys Ser Asn Val Cys Gly Ser Arg Gln Ala Gln Ala Ala 
1               5                   10                  15      


Ala Glu Gly Gly Tyr Gln Arg Tyr Gly Val Arg Ser Tyr Leu His Gln 
            20                  25                  30          


Phe Tyr Glu Asp Cys Thr Ala Ser Ile Trp Glu Tyr Glu Asp Asp Phe 
        35                  40                  45              


Gln Ile Gln Arg Ser Pro Asn Arg Trp Ser Ser Val Phe Trp Lys Val 
    50                  55                  60                  


Gly Leu Ile Ser Gly Thr Val Phe Val Ile Leu Gly Leu Thr Val Leu 
65                  70                  75                  80  


Ala Val Gly Phe Leu Val Pro Pro Lys Ile Glu Ala Phe Gly Glu Ala 
                85                  90                  95      


Asp Phe Val Val Val Asp Thr His Ala Val Gln Phe Asn Ser Ala Leu 
            100                 105                 110         


Asp Met Tyr Lys Leu Ala Gly Ala Val Leu Phe Cys Ile Gly Gly Thr 
        115                 120                 125             


Ser Met Ala Gly Cys Leu Leu Met Ser Val Phe Val Lys Ser Tyr Ser 
    130                 135                 140                 


Lys Glu Glu Lys Phe Leu Gln Gln Lys Phe Lys Glu Arg Ile Ala Asp 
145                 150                 155                 160 


Ile Lys Ala His Thr Gln Pro Val Thr Lys Ala Pro Gly Pro Gly Glu 
                165                 170                 175     


Thr Lys Ile Pro Val Thr Leu Ser Arg Val Gln Asn Val Gln Pro Leu 
            180                 185                 190         


Leu Ala Thr 
        195 


<210>  5625
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  5625

Met Lys Ser Ala Leu Phe Thr Arg Phe Phe Ile Leu Leu Pro Trp Ile 
1               5                   10                  15      


Leu Ile Val Ile Ile Met Leu Asp Val Asp Thr Arg Arg Pro Val Pro 
            20                  25                  30          


Pro Leu Thr Pro Arg Pro Tyr Phe Ser Pro Tyr Ala Val Gly Arg Gly 
        35                  40                  45              


Gly Ala Arg Leu Pro Leu Arg Arg Gly Gly Pro Ala His Gly Thr Gln 
    50                  55                  60                  


Lys Arg Asn Gln Ser Arg Pro Gln Pro Gln Pro Glu Pro Gln Leu Pro 
65                  70                  75                  80  


Thr Ile Tyr Ala Ile Thr Pro Thr Tyr Ser Arg Pro Val Gln Lys Ala 
                85                  90                  95      


Glu Leu Thr Arg Leu Ala Asn Thr Phe Arg Gln Val Ala Gln Leu His 
            100                 105                 110         


Trp Ile Leu Val Glu Asp Ala Ala Ala Arg Ser Glu Leu Val Ser Arg 
        115                 120                 125             


Phe Leu Ala Arg Ala Gly Leu Pro Ser Thr His Leu His Val Pro Thr 
    130                 135                 140                 


Pro Arg Arg Tyr Lys Arg Pro Gly Leu Pro Arg Ala Thr Glu Gln Arg 
145                 150                 155                 160 


Asn Ala Gly Leu Ala Trp Leu Arg Gln Arg His Gln His Gln Arg Ala 
                165                 170                 175     


Gln Pro Gly Val Leu Phe Phe Ala Asp Asp Asp Asn Thr Tyr Ser Leu 
            180                 185                 190         


Glu Leu Phe Gln Glu Met Arg Thr Thr Arg Lys Val Ser Val Trp Pro 
        195                 200                 205             


Val Gly Leu Val Gly Gly Arg Arg Tyr Glu Arg Pro Leu Val Glu Asn 
    210                 215                 220                 


Gly Lys Val Val Gly Trp Tyr Thr Gly Trp Arg Ala Asp Arg Pro Phe 
225                 230                 235                 240 


Ala Ile Asp Met Ala Gly Phe Ala Val Ser Leu Gln Val Ile Leu Ser 
                245                 250                 255     


Asn Pro Lys Ala Val Phe Lys Arg Arg Gly Ser Gln Pro Gly Met Gln 
            260                 265                 270         


Glu Ser Asp Phe Leu Lys Gln Ile Thr Thr Val Glu Glu Leu Glu Pro 
        275                 280                 285             


Lys Ala Asn Asn Cys Thr Lys Val Leu Val Trp His Thr Arg Thr Glu 
    290                 295                 300                 


Lys Val Asn Leu Ala Asn Glu Pro Lys Tyr His Leu Asp Thr Val Lys 
305                 310                 315                 320 


Ile Glu Val 
            


<210>  5626
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  5626

Met Pro Val Ala Val Gly Pro Tyr Gly Gln Ser Gln Pro Ser Cys Phe 
1               5                   10                  15      


Asp Arg Val Lys Met Gly Phe Val Met Gly Cys Ala Val Gly Met Ala 
            20                  25                  30          


Ala Gly Ala Leu Phe Gly Thr Phe Ser Cys Leu Arg Ile Gly Met Arg 
        35                  40                  45              


Gly Arg Glu Leu Met Gly Gly Ile Gly Lys Thr Met Met Gln Ser Gly 
    50                  55                  60                  


Gly Thr Phe Gly Thr Phe Met Ala Ile Gly Met Gly Ile Arg Cys 
65                  70                  75                  


<210>  5627
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  5627

Met Ser His Gln Val Lys Gly Leu Lys Glu Glu Ala Arg Gly Gly Val 
1               5                   10                  15      


Lys Gly Arg Val Lys Ser Gly Ser Pro His Thr Gly Asp Arg Leu Gly 
            20                  25                  30          


Arg Arg Ser Ser Ser Lys Arg Ala Leu Lys Ala Glu Gly Thr Pro Gly 
        35                  40                  45              


Arg Arg Gly Ala Gln Arg Ser Gln Lys Glu Arg Ala Gly Gly Ser Pro 
    50                  55                  60                  


Ser Pro Gly Ser Pro Arg Arg Lys Gln Thr Gly Arg Arg Arg His Arg 
65                  70                  75                  80  


Glu Glu Leu Gly Glu Gln Glu Arg Gly Glu Ala Glu Arg Thr Cys Glu 
                85                  90                  95      


Gly Arg Arg Lys Arg Asp Glu Arg Ala Ser Phe Gln Glu Arg Thr Ala 
            100                 105                 110         


Ala Pro Lys Arg Glu Lys Glu Ile Pro Arg Arg Glu Glu Lys Ser Lys 
        115                 120                 125             


Arg Gln Lys Lys Pro Arg Ser Ser Ser Leu Ala Ser Ser Ala Ser Gly 
    130                 135                 140                 


Gly Glu Ser Leu Ser Glu Glu Glu Leu Ala Gln Ile Leu Glu Gln Val 
145                 150                 155                 160 


Glu Glu Lys Lys Lys Leu Ile Ala Thr Met Arg Ser Lys Pro Trp Pro 
                165                 170                 175     


Met Ala Lys Lys Leu Thr Glu Leu Arg Glu Ala Gln Glu Phe Val Glu 
            180                 185                 190         


Lys Tyr Glu Gly Ala Leu Gly Lys Gly Lys Gly Lys Gln Leu Tyr Ala 
        195                 200                 205             


Tyr Lys Met Leu Met Ala Lys Lys Trp Val Lys Phe Lys Arg Asp Phe 
    210                 215                 220                 


Asp Asn Phe Lys Thr Gln Cys Ile Pro Trp Glu Met Lys Ile Lys Asp 
225                 230                 235                 240 


Ile Glu Ser His Phe Gly Ser Ser Val Ala Ser Tyr Phe Ile Phe Leu 
                245                 250                 255     


Arg Trp Met Tyr Gly Val Asn Leu Val Leu Phe Gly Leu Ile Phe Gly 
            260                 265                 270         


Leu Val Ile Ile Pro Glu Val Leu Met Gly Met Pro Tyr Gly Ser Ile 
        275                 280                 285             


Pro Arg Lys Thr Val Pro Arg Ala Glu Glu Glu Lys Ala Met Asp Phe 
    290                 295                 300                 


Ser Val Leu Trp Asp Phe Glu Gly Tyr Ile Lys Tyr Ser Ala Leu Phe 
305                 310                 315                 320 


Tyr Gly Tyr Tyr Asn Asn Gln Arg Thr Ile Gly Trp Leu Arg Tyr Arg 
                325                 330                 335     


Leu Pro Met Ala Tyr Phe Met Val Gly Val Ser Val Phe Gly Tyr Ser 
            340                 345                 350         


Leu Ile Ile Val Ile Arg Ser Met Ala Ser Asn Thr Gln Gly Ser Thr 
        355                 360                 365             


Gly Glu Gly Glu Ser Asp Asn Phe Thr Phe Ser Phe Lys Met Phe Thr 
    370                 375                 380                 


Ser Trp Asp Tyr Leu Ile Gly Asn Ser Glu Thr Ala Asp Asn Lys Tyr 
385                 390                 395                 400 


Ala Ser Ile Thr Thr Ser Phe Lys Glu Ser Ile Val Asp Glu Gln Glu 
                405                 410                 415     


Ser Asn Lys Glu Glu Asn Ile His Leu Thr Arg Phe Leu Arg Val Leu 
            420                 425                 430         


Ala Asn Phe Leu Ile Ile Cys Cys Leu Cys Gly Ser Gly Tyr Leu Ile 
        435                 440                 445             


Tyr Phe Val Val Lys Arg Ser Gln Gln Phe Ser Lys Met Gln Asn Val 
    450                 455                 460                 


Ser Trp Tyr Glu Arg Asn Glu Val Glu Ile Val Met Ser Leu Leu Gly 
465                 470                 475                 480 


Met Phe Cys Pro Pro Leu Phe Glu Thr Ile Ala Ala Leu Glu Asn Tyr 
                485                 490                 495     


His Pro Arg Thr Gly Leu Lys Trp Gln Leu Gly Arg Ile Phe Ala Leu 
            500                 505                 510         


Phe Leu Gly Asn Leu Tyr Thr Phe Leu Leu Ala Leu Met Asp Asp Val 
        515                 520                 525             


His Leu Lys Leu Ala Asn Glu Glu Thr Ile Lys Asn Ile Thr His Trp 
    530                 535                 540                 


Thr Leu Phe Asn Tyr Tyr Asn Ser Ser Gly Trp Asn Glu Ser Val Pro 
545                 550                 555                 560 


Arg Pro Pro Leu His Pro Ala Asp Val Pro Arg Gly Ser Cys Trp Glu 
                565                 570                 575     


Thr Ala Val Gly Ile Glu Phe Met Arg Leu Thr Val Ser Asp Met Leu 
            580                 585                 590         


Val Thr Tyr Ile Thr Ile Leu Leu Gly Asp Phe Leu Arg Ala Cys Phe 
        595                 600                 605             


Val Arg Phe Met Asn Tyr Cys Trp Cys Trp Asp Leu Glu Ala Gly Phe 
    610                 615                 620                 


Pro Ser Tyr Ala Glu Phe Asp Ile Ser Gly Asn Val Leu Gly Leu Ile 
625                 630                 635                 640 


Phe Asn Gln Gly Met Ile Trp Met Gly Ser Phe Tyr Ala Pro Gly Leu 
                645                 650                 655     


Val Gly Ile Asn Val Leu Arg Leu Leu Thr Ser Met Tyr Phe Gln Cys 
            660                 665                 670         


Trp Ala Val Met Ser Ser Asn Val Pro His Glu Arg Val Phe Lys Ala 
        675                 680                 685             


Ser Arg Ser Asn Asn Phe Tyr Met Gly Leu Leu Leu Leu Val Leu Phe 
    690                 695                 700                 


Leu Ser Leu Leu Pro Val Ala Tyr Thr Ile Met Ser Leu Pro Pro Ser 
705                 710                 715                 720 


Phe Asp Cys Gly Pro Phe Ser Gly Lys Asn Arg Met Tyr Asp Val Leu 
                725                 730                 735     


Gln Glu Thr Ile Glu Asn Asp Phe Pro Thr Phe Leu Gly Lys Ile Phe 
            740                 745                 750         


Ala Phe Leu Ala Asn Pro Gly Leu Ile Ile Pro Ala Ile Leu Leu Met 
        755                 760                 765             


Phe Leu Ala Ile Tyr Tyr Leu Asn Ser Val Ser Lys Ser Leu Ser Arg 
    770                 775                 780                 


Ala Asn Ala Gln Leu Arg Lys Lys Ile Gln Val Leu Arg Glu Val Glu 
785                 790                 795                 800 


Lys Ser His Lys Ser Val Lys Gly Lys Ala Thr Ala Arg Asp Ser Glu 
                805                 810                 815     


Asp Thr Pro Lys Ser Ser Ser Lys Asn Ala Thr Gln Leu Gln Leu Thr 
            820                 825                 830         


Lys Glu Glu Thr Thr Pro Pro Ser Ala Ser Gln Ser Gln Ala Met Asp 
        835                 840                 845             


Lys Lys Ala Gln Gly Pro Gly Thr Ser Asn Ser Ala Ser Arg Thr Thr 
    850                 855                 860                 


Leu Pro Ala Ser Gly His Leu Pro Ile Ser Arg Pro Pro Gly Ile Gly 
865                 870                 875                 880 


Pro Asp Ser Gly His Ala Pro Ser Gln Thr His Pro Trp Arg Ser Ala 
                885                 890                 895     


Ser Gly Lys Ser Ala Gln Arg Pro Pro His 
            900                 905     


<210>  5628
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  5628

Met Ala Pro Gln Thr Leu Leu Pro Val Leu Val Leu Cys Val Leu Leu 
1               5                   10                  15      


Leu Gln Ala Gln Gly Gly Tyr Arg Asp Lys Lys Arg Met Gln Lys Thr 
            20                  25                  30          


Gln Leu Ser Pro Glu Ile Lys Val Cys Gln Gln Gln Pro Lys Leu Tyr 
        35                  40                  45              


Leu Cys Lys His Leu Cys Glu Ser His Arg Asp Cys Gln Ala Asn Asn 
    50                  55                  60                  


Ile Cys Cys Ser Thr Tyr Cys Gly Asn Val Cys Met Ser Ile Leu 
65                  70                  75                  


<210>  5629
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  5629

Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu 
            20                  25                  30          


Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala Ala Gly 
        35                  40                  45              


Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro Val Gly 
    50                  55                  60                  


Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu Ile Tyr 
65                  70                  75                  80  


Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu 
                85                  90                  95      


Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn Ile Thr 
            100                 105                 110         


Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 
        115                 120                 125             


Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val 
    130                 135                 140                 


Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala 
145                 150                 155                 160 


Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser 
                165                 170                 175     


Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser 
            180                 185                 190         


Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser 
        195                 200                 205             


Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser 
    210                 215                 220                 


Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu 
225                 230                 235                 240 


Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu 
                245                 250                 255     


Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr 
            260                 265                 270         


Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu 
        275                 280                 285             


Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu 
    290                 295                 300                 


Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val 
305                 310                 315                 320 


Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp 
                325                 330                 335     


Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His 
            340                 345                 350         


Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn 
        355                 360                 365             


Glu Arg Asn Ile Tyr Ile Val Val Gly Val Val Cys Thr Leu Leu Val 
    370                 375                 380                 


Ala Leu Leu Met Ala Ala Leu Tyr Leu Val Arg Ile Arg Gln Lys Lys 
385                 390                 395                 400 


Ala Gln Gly Ser Thr Ser Ser Thr Arg Leu His Glu Pro Glu Lys Asn 
                405                 410                 415     


Ala Arg Glu Ile Thr Gln Asp Thr Asn Asp Ile Thr Tyr Ala Asp Leu 
            420                 425                 430         


Asn Leu Pro Lys Gly Lys Lys Pro Ala Pro Gln Ala Ala Glu Pro Asn 
        435                 440                 445             


Asn His Thr Glu Tyr Ala Ser Ile Gln Thr Ser Pro Gln Pro Ala Ser 
    450                 455                 460                 


Glu Asp Thr Leu Thr Tyr Ala Asp Leu Asp Met Val His Leu Asn Arg 
465                 470                 475                 480 


Thr Pro Lys Gln Pro Ala Pro Lys Pro Glu Pro Ser Phe Ser Glu Tyr 
                485                 490                 495     


Ala Ser Val Gln Val Pro Arg Lys 
            500                 


<210>  5630
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  5630

Met Pro Val Pro Ala Ser Trp Pro His Pro Pro Gly Pro Phe Leu Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Gly Leu Thr Glu Val Ala Gly Glu Glu Glu Leu 
            20                  25                  30          


Gln Met Ile Gln Pro Glu Lys Leu Leu Leu Val Thr Val Gly Lys Thr 
        35                  40                  45              


Ala Thr Leu His Cys Thr Val Thr Ser Leu Leu Pro Val Gly Pro Val 
    50                  55                  60                  


Leu Trp Phe Arg Gly Val Gly Pro Gly Arg Glu Leu Ile Tyr Asn Gln 
65                  70                  75                  80  


Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu Thr Lys 
                85                  90                  95      


Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Ser Ser Ile Thr Pro Ala 
            100                 105                 110         


Asp Val Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser Pro Glu 
        115                 120                 125             


Asn Val Glu Phe Lys Ser Gly Pro Gly Thr Glu Met Ala Leu Gly Gly 
    130                 135                 140                 


Pro Ala Ser Ser Leu Thr Ala Leu Leu Leu Ile Ala Val Leu Leu Gly 
145                 150                 155                 160 


Pro Ile Tyr Val Pro Trp Lys Gln Lys Thr 
                165                 170 


<210>  5631
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  5631

Met Asn Asn Asn Thr Thr Cys Ile Gln Pro Ser Met Ile Ser Ser Met 
1               5                   10                  15      


Ala Leu Pro Ile Ile Tyr Ile Leu Leu Cys Ile Val Gly Val Phe Gly 
            20                  25                  30          


Asn Thr Leu Ser Gln Trp Ile Phe Leu Thr Lys Ile Gly Lys Lys Thr 
        35                  40                  45              


Ser Thr His Ile Tyr Leu Ser His Leu Val Thr Ala Asn Leu Leu Val 
    50                  55                  60                  


Cys Ser Ala Met Pro Phe Met Ser Ile Tyr Phe Leu Lys Gly Phe Gln 
65                  70                  75                  80  


Trp Glu Tyr Gln Ser Ala Gln Cys Arg Val Val Asn Phe Leu Gly Thr 
                85                  90                  95      


Leu Ser Met His Ala Ser Met Phe Val Ser Leu Leu Ile Leu Ser Trp 
            100                 105                 110         


Ile Ala Ile Ser Arg Tyr Ala Thr Leu Met Gln Lys Asp Ser Ser Gln 
        115                 120                 125             


Glu Thr Thr Ser Cys Tyr Glu Lys Ile Phe Tyr Gly His Leu Leu Lys 
    130                 135                 140                 


Lys Phe Arg Gln Pro Asn Phe Ala Arg Lys Leu Cys Ile Tyr Ile Trp 
145                 150                 155                 160 


Gly Val Val Leu Gly Ile Ile Ile Pro Val Thr Val Tyr Tyr Ser Val 
                165                 170                 175     


Ile Glu Ala Thr Glu Gly Glu Glu Ser Leu Cys Tyr Asn Arg Gln Met 
            180                 185                 190         


Glu Leu Gly Ala Met Ile Ser Gln Ile Ala Gly Leu Ile Gly Thr Thr 
        195                 200                 205             


Phe Ile Gly Phe Ser Phe Leu Val Val Leu Thr Ser Tyr Tyr Ser Phe 
    210                 215                 220                 


Val Ser His Leu Arg Lys Ile Arg Thr Cys Thr Ser Ile Met Glu Lys 
225                 230                 235                 240 


Asp Leu Thr Tyr Ser Ser Val Lys Arg His Leu Leu Val Ile Gln Ile 
                245                 250                 255     


Leu Leu Ile Val Cys Phe Leu Pro Tyr Ser Ile Phe Lys Pro Ile Phe 
            260                 265                 270         


Tyr Val Leu His Gln Arg Asp Asn Cys Gln Gln Leu Asn Tyr Leu Ile 
        275                 280                 285             


Glu Thr Lys Asn Ile Leu Thr Cys Leu Ala Ser Ala Arg Ser Ser Thr 
    290                 295                 300                 


Asp Pro Ile Ile Phe Leu Leu Leu Asp Lys Thr Phe Lys Lys Thr Leu 
305                 310                 315                 320 


Tyr Asn Leu Phe Thr Lys Ser Asn Ser Ala His Met Gln Ser Tyr Gly 
                325                 330                 335     


<210>  5632
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  5632

Met Asn Glu Pro Leu Asp Tyr Leu Ala Asn Ala Ser Asp Phe Pro Asp 
1               5                   10                  15      


Tyr Ala Ala Ala Phe Gly Asn Cys Thr Asp Glu Asn Ile Pro Leu Lys 
            20                  25                  30          


Met His Tyr Leu Pro Val Ile Tyr Gly Ile Ile Phe Leu Val Gly Phe 
        35                  40                  45              


Pro Gly Asn Ala Val Val Ile Ser Thr Tyr Ile Phe Lys Met Arg Pro 
    50                  55                  60                  


Trp Lys Ser Ser Thr Ile Ile Met Leu Asn Leu Ala Cys Thr Asp Leu 
65                  70                  75                  80  


Leu Tyr Leu Thr Ser Leu Pro Phe Leu Ile His Tyr Tyr Ala Ser Gly 
                85                  90                  95      


Glu Asn Trp Ile Phe Gly Asp Phe Met Cys Lys Phe Ile Arg Phe Ser 
            100                 105                 110         


Phe His Phe Asn Leu Tyr Ser Ser Ile Leu Phe Leu Thr Cys Phe Ser 
        115                 120                 125             


Ile Phe Arg Tyr Cys Val Ile Ile His Pro Met Ser Cys Phe Ser Ile 
    130                 135                 140                 


His Lys Thr Arg Cys Ala Val Val Ala Cys Ala Val Val Trp Ile Ile 
145                 150                 155                 160 


Ser Leu Val Ala Val Ile Pro Met Thr Phe Leu Ile Thr Ser Thr Asn 
                165                 170                 175     


Arg Thr Asn Arg Ser Ala Cys Leu Asp Leu Thr Ser Ser Asp Glu Leu 
            180                 185                 190         


Asn Thr Ile Lys Trp Tyr Asn Leu Ile Leu Thr Ala Thr Thr Phe Cys 
        195                 200                 205             


Leu Pro Leu Val Ile Val Thr Leu Cys Tyr Thr Thr Ile Ile His Thr 
    210                 215                 220                 


Leu Thr His Gly Leu Gln Thr Asp Ser Cys Leu Lys Gln Lys Ala Arg 
225                 230                 235                 240 


Arg Leu Thr Ile Leu Leu Leu Leu Ala Phe Tyr Val Cys Phe Leu Pro 
                245                 250                 255     


Phe His Ile Leu Arg Val Ile Arg Ile Glu Ser Arg Leu Leu Ser Ile 
            260                 265                 270         


Ser Cys Ser Ile Glu Asn Gln Ile His Glu Ala Tyr Ile Val Ser Arg 
        275                 280                 285             


Pro Leu Ala Ala Leu Asn Thr Phe Gly Asn Leu Leu Leu Tyr Val Val 
    290                 295                 300                 


Val Ser Asp Asn Phe Gln Gln Ala Val Cys Ser Thr Val Arg Cys Lys 
305                 310                 315                 320 


Val Ser Gly Asn Leu Glu Gln Ala Lys Lys Ile Ser Tyr Ser Asn Asn 
                325                 330                 335     


Pro 
    


<210>  5633
<211>  363
<212>  PRT
<213>  Homo sapiens

<400>  5633

Met Gly Pro Gly Glu Ala Leu Leu Ala Gly Leu Leu Val Met Val Leu 
1               5                   10                  15      


Ala Val Ala Leu Leu Ser Asn Ala Leu Val Leu Leu Cys Cys Ala Tyr 
            20                  25                  30          


Ser Ala Glu Leu Arg Thr Arg Ala Ser Gly Val Leu Leu Val Asn Leu 
        35                  40                  45              


Ser Leu Gly His Leu Leu Leu Ala Ala Leu Asp Met Pro Phe Thr Leu 
    50                  55                  60                  


Leu Gly Val Met Arg Gly Arg Thr Pro Ser Ala Pro Gly Ala Cys Gln 
65                  70                  75                  80  


Val Ile Gly Phe Leu Asp Thr Phe Leu Ala Ser Asn Ala Ala Leu Ser 
                85                  90                  95      


Val Ala Ala Leu Ser Ala Asp Gln Trp Leu Ala Val Gly Phe Pro Leu 
            100                 105                 110         


Arg Tyr Ala Gly Arg Leu Arg Pro Arg Tyr Ala Gly Leu Leu Leu Gly 
        115                 120                 125             


Cys Ala Trp Gly Gln Ser Leu Ala Phe Ser Gly Ala Ala Leu Gly Cys 
    130                 135                 140                 


Ser Trp Leu Gly Tyr Ser Ser Ala Phe Ala Ser Cys Ser Leu Arg Leu 
145                 150                 155                 160 


Pro Pro Glu Pro Glu Arg Pro Arg Phe Ala Ala Phe Thr Ala Thr Leu 
                165                 170                 175     


His Ala Val Gly Phe Val Leu Pro Leu Ala Val Leu Cys Leu Thr Ser 
            180                 185                 190         


Leu Gln Val His Arg Val Ala Arg Arg His Cys Gln Arg Met Asp Thr 
        195                 200                 205             


Val Thr Met Lys Ala Leu Ala Leu Leu Ala Asp Leu His Pro Ser Val 
    210                 215                 220                 


Arg Gln Arg Cys Leu Ile Gln Gln Lys Arg Arg Arg His Arg Ala Thr 
225                 230                 235                 240 


Arg Lys Ile Gly Ile Ala Ile Ala Thr Phe Leu Ile Cys Phe Ala Pro 
                245                 250                 255     


Tyr Val Met Thr Arg Leu Ala Glu Leu Val Pro Phe Val Thr Val Asn 
            260                 265                 270         


Ala Gln Trp Gly Ile Leu Ser Lys Cys Leu Thr Tyr Ser Lys Ala Val 
        275                 280                 285             


Ala Asp Pro Phe Thr Tyr Ser Leu Leu Arg Arg Pro Phe Arg Gln Val 
    290                 295                 300                 


Leu Ala Gly Met Val His Arg Leu Leu Lys Arg Thr Pro Arg Pro Ala 
305                 310                 315                 320 


Ser Thr His Asp Ser Ser Leu Asp Val Ala Gly Met Val His Gln Leu 
                325                 330                 335     


Leu Lys Arg Thr Pro Arg Pro Ala Ser Thr His Asn Gly Ser Val Asp 
            340                 345                 350         


Thr Glu Asn Asp Ser Cys Leu Gln Gln Thr His 
        355                 360             


<210>  5634
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  5634

Met Lys Ala Val Val Gln Arg Val Thr Arg Ala Ser Val Thr Val Gly 
1               5                   10                  15      


Gly Glu Gln Ile Ser Ala Ile Gly Arg Gly Ile Cys Val Leu Leu Gly 
            20                  25                  30          


Ile Ser Leu Glu Asp Thr Gln Lys Glu Leu Glu His Met Val Arg Lys 
        35                  40                  45              


Ile Leu Asn Leu Arg Val Phe Glu Asp Glu Ser Gly Lys His Trp Ser 
    50                  55                  60                  


Lys Ser Val Met Asp Lys Gln Tyr Glu Ile Leu Cys Val Ser Gln Phe 
65                  70                  75                  80  


Thr Leu Gln Cys Val Leu Lys Gly Asn Lys Pro Asp Phe His Leu Ala 
                85                  90                  95      


Met Pro Thr Glu Gln Ala Glu Gly Phe Tyr Asn Ser Phe Leu Glu Gln 
            100                 105                 110         


Leu Arg Lys Thr Tyr Arg Pro Glu Leu Ile Lys Asp Gly Lys Phe Gly 
        115                 120                 125             


Ala Tyr Met Gln Val His Ile Gln Asn Asp Gly Pro Val Thr Ile Glu 
    130                 135                 140                 


Leu Glu Ser Pro Ala Pro Gly Thr Ala Thr Ser Asp Pro Lys Gln Leu 
145                 150                 155                 160 


Ser Lys Leu Glu Lys Gln Gln Gln Arg Lys Glu Lys Thr Arg Ala Lys 
                165                 170                 175     


Gly Pro Ser Glu Ser Ser Lys Glu Arg Asn Thr Pro Arg Lys Glu Asp 
            180                 185                 190         


Arg Ser Ala Ser Ser Gly Ala Glu Gly Asp Val Ser Ser Glu Arg Glu 
        195                 200                 205             


Pro 
    


<210>  5635
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  5635

Met Ala Gly Leu Leu Ala Leu Leu Gly Pro Ala Gly Arg Val Gly Ala 
1               5                   10                  15      


Arg Val Arg Pro Arg Ala Thr Trp Leu Leu Gly Ala Thr Ala Pro Cys 
            20                  25                  30          


Ala Pro Pro Pro Leu Ala Leu Ala Leu Leu Pro Pro Arg Leu Asp Ala 
        35                  40                  45              


Arg Leu Leu Arg Thr Ala Arg Gly Asp Cys Arg Gly His Gln Asp Pro 
    50                  55                  60                  


Ser Gln Ala Thr Gly Thr Thr Gly Ser Ser Val Ser Cys Thr Glu Glu 
65                  70                  75                  80  


Lys Lys Gln Ser Lys Ser Gln Gln Leu Lys Lys Ile Phe Gln Glu Tyr 
                85                  90                  95      


Gly Thr Val Gly Val Ser Leu His Ile Gly Ile Ser Leu Ile Ser Leu 
            100                 105                 110         


Gly Ile Phe Tyr Met Val Val Ser Ser Gly Val Asp Met Pro Ala Ile 
        115                 120                 125             


Leu Leu Lys Leu Gly Phe Lys Glu Ser Leu Val Gln Ser Lys Met Ala 
    130                 135                 140                 


Ala Gly Thr Ser Thr Phe Val Val Ala Tyr Ala Ile His Lys Leu Phe 
145                 150                 155                 160 


Ala Pro Val Arg Ile Ser Ile Thr Leu Val Ser Val Pro Leu Ile Val 
                165                 170                 175     


Arg Tyr Phe Arg Lys Val Gly Phe Phe Lys Pro Pro Ala Ala Lys Pro 
            180                 185                 190         


<210>  5636
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  5636

Met Met Ala Glu Pro Trp Gln Ala Leu Gln Leu Leu Leu Ala Ile Leu 
1               5                   10                  15      


Leu Thr Leu Met Ala Leu Pro Tyr Gln Ala Arg Lys Lys Thr Phe Leu 
            20                  25                  30          


Ser Val His Glu Val Met Ala Val Glu Asn Tyr Ala Lys Asp Ser Leu 
        35                  40                  45              


Gln Trp Ile Thr Asp Gln Tyr Asn Lys Glu Ser Asp Asp Lys Tyr His 
    50                  55                  60                  


Phe Arg Ile Phe Arg Val Leu Lys Val Gln Arg Gln Gln Val Asn Cys 
65                  70                  75                  80  


Phe Phe Ser Val Phe Ala Val Pro Trp Phe Glu Gln Tyr Lys Ile Leu 
                85                  90                  95      


Asn Lys Ser Cys Ser Ser Asp 
            100             


<210>  5637
<211>  793
<212>  PRT
<213>  Homo sapiens

<400>  5637

Met Asp Ser Trp Phe Ile Leu Val Leu Leu Gly Ser Gly Leu Ile Cys 
1               5                   10                  15      


Val Ser Ala Asn Asn Ala Thr Thr Val Ala Pro Ser Val Gly Ile Thr 
            20                  25                  30          


Arg Leu Ile Asn Ser Ser Thr Ala Glu Pro Val Lys Glu Glu Ala Lys 
        35                  40                  45              


Thr Ser Asn Pro Thr Ser Ser Leu Thr Ser Leu Ser Val Ala Pro Thr 
    50                  55                  60                  


Phe Ser Pro Asn Ile Thr Leu Gly Pro Thr Tyr Leu Thr Thr Val Asn 
65                  70                  75                  80  


Ser Ser Asp Ser Asp Asn Gly Thr Thr Arg Thr Ala Ser Thr Asn Ser 
                85                  90                  95      


Ile Gly Ile Thr Ile Ser Pro Asn Gly Thr Trp Leu Pro Asp Asn Gln 
            100                 105                 110         


Phe Thr Asp Ala Arg Thr Glu Pro Trp Glu Gly Asn Ser Ser Thr Ala 
        115                 120                 125             


Ala Thr Thr Pro Glu Thr Phe Pro Pro Ser Asp Glu Thr Pro Ile Ile 
    130                 135                 140                 


Ala Val Met Val Ala Leu Ser Ser Leu Leu Val Ile Val Phe Ile Ile 
145                 150                 155                 160 


Ile Val Leu Tyr Met Leu Arg Phe Lys Lys Tyr Lys Gln Ala Gly Ser 
                165                 170                 175     


His Ser Asn Ser Phe Arg Leu Ser Asn Gly Arg Thr Glu Asp Val Glu 
            180                 185                 190         


Pro Gln Ser Val Pro Leu Leu Ala Arg Ser Pro Ser Thr Asn Arg Lys 
        195                 200                 205             


Tyr Pro Pro Leu Pro Val Asp Lys Leu Glu Glu Glu Ile Asn Arg Arg 
    210                 215                 220                 


Met Ala Asp Asp Asn Lys Leu Phe Arg Glu Glu Phe Asn Ala Leu Pro 
225                 230                 235                 240 


Ala Cys Pro Ile Gln Ala Thr Cys Glu Ala Ala Ser Lys Glu Glu Asn 
                245                 250                 255     


Lys Glu Lys Asn Arg Tyr Val Asn Ile Leu Pro Tyr Asp His Ser Arg 
            260                 265                 270         


Val His Leu Thr Pro Val Glu Gly Val Pro Asp Ser Asp Tyr Ile Asn 
        275                 280                 285             


Ala Ser Phe Ile Asn Gly Tyr Gln Glu Lys Asn Lys Phe Ile Ala Ala 
    290                 295                 300                 


Gln Gly Pro Lys Glu Glu Thr Val Asn Asp Phe Trp Arg Met Ile Trp 
305                 310                 315                 320 


Glu Gln Asn Thr Ala Thr Ile Val Met Val Thr Asn Leu Lys Glu Arg 
                325                 330                 335     


Lys Glu Cys Lys Cys Ala Gln Tyr Trp Pro Asp Gln Gly Cys Trp Thr 
            340                 345                 350         


Tyr Gly Asn Ile Arg Val Ser Val Glu Asp Val Thr Val Leu Val Asp 
        355                 360                 365             


Tyr Thr Val Arg Lys Phe Cys Ile Gln Gln Val Gly Asp Met Thr Asn 
    370                 375                 380                 


Arg Lys Pro Gln Arg Leu Ile Thr Gln Phe His Phe Thr Ser Trp Pro 
385                 390                 395                 400 


Asp Phe Gly Val Pro Phe Thr Pro Ile Gly Met Leu Lys Phe Leu Lys 
                405                 410                 415     


Lys Val Lys Ala Cys Asn Pro Gln Tyr Ala Gly Ala Ile Val Val His 
            420                 425                 430         


Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Phe Val Val Ile Asp Ala 
        435                 440                 445             


Met Leu Asp Met Met His Thr Glu Arg Lys Val Asp Val Tyr Gly Phe 
    450                 455                 460                 


Val Ser Arg Ile Arg Ala Gln Arg Cys Gln Met Val Gln Thr Asp Met 
465                 470                 475                 480 


Gln Tyr Val Phe Ile Tyr Gln Ala Leu Leu Glu His Tyr Leu Tyr Gly 
                485                 490                 495     


Asp Thr Glu Leu Glu Val Thr Ser Leu Glu Thr His Leu Gln Lys Ile 
            500                 505                 510         


Tyr Asn Lys Ile Pro Gly Thr Ser Asn Asn Gly Leu Glu Glu Glu Phe 
        515                 520                 525             


Lys Lys Leu Thr Ser Ile Lys Ile Gln Asn Asp Lys Met Arg Thr Gly 
    530                 535                 540                 


Asn Leu Pro Ala Asn Met Lys Lys Asn Arg Val Leu Gln Ile Ile Pro 
545                 550                 555                 560 


Tyr Glu Phe Asn Arg Val Ile Ile Pro Val Lys Arg Gly Glu Glu Asn 
                565                 570                 575     


Thr Asp Tyr Val Asn Ala Ser Phe Ile Asp Gly Tyr Arg Gln Lys Asp 
            580                 585                 590         


Ser Tyr Ile Ala Ser Gln Gly Pro Leu Leu His Thr Ile Glu Asp Phe 
        595                 600                 605             


Trp Arg Met Ile Trp Glu Trp Lys Ser Cys Ser Ile Val Met Leu Thr 
    610                 615                 620                 


Glu Leu Glu Glu Arg Gly Gln Glu Lys Cys Ala Gln Tyr Trp Pro Ser 
625                 630                 635                 640 


Asp Gly Leu Val Ser Tyr Gly Asp Ile Thr Val Glu Leu Lys Lys Glu 
                645                 650                 655     


Glu Glu Cys Glu Ser Tyr Thr Val Arg Asp Leu Leu Val Thr Asn Thr 
            660                 665                 670         


Arg Glu Asn Lys Ser Arg Gln Ile Arg Gln Phe His Phe His Gly Trp 
        675                 680                 685             


Pro Glu Val Gly Ile Pro Ser Asp Gly Lys Gly Met Ile Ser Ile Ile 
    690                 695                 700                 


Ala Ala Val Gln Lys Gln Gln Gln Gln Ser Gly Asn His Pro Ile Thr 
705                 710                 715                 720 


Val His Cys Ser Ala Gly Ala Gly Arg Thr Gly Thr Phe Cys Ala Leu 
                725                 730                 735     


Ser Thr Val Leu Glu Arg Val Lys Ala Glu Gly Ile Leu Asp Val Phe 
            740                 745                 750         


Gln Thr Val Lys Ser Leu Arg Leu Gln Arg Pro His Met Val Gln Thr 
        755                 760                 765             


Leu Glu Gln Tyr Glu Phe Cys Tyr Lys Val Val Gln Glu Tyr Ile Asp 
    770                 775                 780                 


Ala Phe Ser Asp Tyr Ala Asn Phe Lys 
785                 790             


<210>  5638
<211>  793
<212>  PRT
<213>  Homo sapiens

<400>  5638

Met Asp Ser Trp Phe Ile Leu Val Leu Leu Gly Ser Gly Leu Ile Cys 
1               5                   10                  15      


Val Ser Ala Asn Asn Ala Thr Thr Val Ala Pro Ser Val Gly Ile Thr 
            20                  25                  30          


Arg Leu Ile Asn Ser Ser Thr Ala Glu Pro Val Lys Glu Glu Ala Lys 
        35                  40                  45              


Thr Ser Asn Pro Thr Ser Ser Leu Thr Ser Leu Ser Val Ala Pro Thr 
    50                  55                  60                  


Phe Ser Pro Asn Ile Thr Leu Gly Pro Thr Tyr Leu Thr Thr Val Asn 
65                  70                  75                  80  


Ser Ser Asp Ser Asp Asn Gly Thr Thr Arg Thr Ala Ser Thr Asn Ser 
                85                  90                  95      


Ile Gly Ile Thr Ile Ser Pro Asn Gly Thr Trp Leu Pro Asp Asn Gln 
            100                 105                 110         


Phe Thr Asp Ala Arg Thr Glu Pro Trp Glu Gly Asn Ser Ser Thr Ala 
        115                 120                 125             


Ala Thr Thr Pro Glu Thr Phe Pro Pro Ser Asp Glu Thr Pro Ile Ile 
    130                 135                 140                 


Ala Val Met Val Ala Leu Ser Ser Leu Leu Val Ile Val Phe Ile Ile 
145                 150                 155                 160 


Ile Val Leu Tyr Met Leu Arg Phe Lys Lys Tyr Lys Gln Ala Gly Ser 
                165                 170                 175     


His Ser Asn Ser Phe Arg Leu Ser Asn Gly Arg Thr Glu Asp Val Glu 
            180                 185                 190         


Pro Gln Ser Val Pro Leu Leu Ala Arg Ser Pro Ser Thr Asn Arg Lys 
        195                 200                 205             


Tyr Pro Pro Leu Pro Val Asp Lys Leu Glu Glu Glu Ile Asn Arg Arg 
    210                 215                 220                 


Met Ala Asp Asp Asn Lys Leu Phe Arg Glu Glu Phe Asn Ala Leu Pro 
225                 230                 235                 240 


Ala Cys Pro Ile Gln Ala Thr Cys Glu Ala Ala Ser Lys Glu Glu Asn 
                245                 250                 255     


Lys Glu Lys Asn Arg Tyr Val Asn Ile Leu Pro Tyr Asp His Ser Arg 
            260                 265                 270         


Val His Leu Thr Pro Val Glu Gly Val Pro Asp Ser Asp Tyr Ile Asn 
        275                 280                 285             


Ala Ser Phe Ile Asn Gly Tyr Gln Glu Lys Asn Lys Phe Ile Ala Ala 
    290                 295                 300                 


Gln Gly Pro Lys Glu Glu Thr Val Asn Asp Phe Trp Arg Met Ile Trp 
305                 310                 315                 320 


Glu Gln Asn Thr Ala Thr Ile Val Met Val Thr Asn Leu Lys Glu Arg 
                325                 330                 335     


Lys Glu Cys Lys Cys Ala Gln Tyr Trp Pro Asp Gln Gly Cys Trp Thr 
            340                 345                 350         


Tyr Gly Asn Ile Arg Val Ser Val Glu Asp Val Thr Val Leu Val Asp 
        355                 360                 365             


Tyr Thr Val Arg Lys Phe Cys Ile Gln Gln Val Gly Asp Met Thr Asn 
    370                 375                 380                 


Arg Lys Pro Gln Arg Leu Ile Thr Gln Phe His Phe Thr Ser Trp Pro 
385                 390                 395                 400 


Asp Phe Gly Val Pro Phe Thr Pro Ile Gly Met Leu Lys Phe Leu Lys 
                405                 410                 415     


Lys Val Lys Ala Cys Asn Pro Gln Tyr Ala Gly Ala Ile Val Val His 
            420                 425                 430         


Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Phe Val Val Ile Asp Ala 
        435                 440                 445             


Met Leu Asp Met Met His Thr Glu Arg Lys Val Asp Val Tyr Gly Phe 
    450                 455                 460                 


Val Ser Arg Ile Arg Ala Gln Arg Cys Gln Met Val Gln Thr Asp Met 
465                 470                 475                 480 


Gln Tyr Val Phe Ile Tyr Gln Ala Leu Leu Glu His Tyr Leu Tyr Gly 
                485                 490                 495     


Asp Thr Glu Leu Glu Val Thr Ser Leu Glu Thr His Leu Gln Lys Ile 
            500                 505                 510         


Tyr Asn Lys Ile Pro Gly Thr Ser Asn Asn Gly Leu Glu Glu Glu Phe 
        515                 520                 525             


Lys Lys Leu Thr Ser Ile Lys Ile Gln Asn Asp Lys Met Arg Thr Gly 
    530                 535                 540                 


Asn Leu Pro Ala Asn Met Lys Lys Asn Arg Val Leu Gln Ile Ile Pro 
545                 550                 555                 560 


Tyr Glu Phe Asn Arg Val Ile Ile Pro Val Lys Arg Gly Glu Glu Asn 
                565                 570                 575     


Thr Asp Tyr Val Asn Ala Ser Phe Ile Asp Gly Tyr Arg Gln Lys Asp 
            580                 585                 590         


Ser Tyr Ile Ala Ser Gln Gly Pro Leu Leu His Thr Ile Glu Asp Phe 
        595                 600                 605             


Trp Arg Met Ile Trp Glu Trp Lys Ser Cys Ser Ile Val Met Leu Thr 
    610                 615                 620                 


Glu Leu Glu Glu Arg Gly Gln Glu Lys Cys Ala Gln Tyr Trp Pro Ser 
625                 630                 635                 640 


Asp Gly Leu Val Ser Tyr Gly Asp Ile Thr Val Glu Leu Lys Lys Glu 
                645                 650                 655     


Glu Glu Cys Glu Ser Tyr Thr Val Arg Asp Leu Leu Val Thr Asn Thr 
            660                 665                 670         


Arg Glu Asn Lys Ser Arg Gln Ile Arg Gln Phe His Phe His Gly Trp 
        675                 680                 685             


Pro Glu Val Gly Ile Pro Ser Asp Gly Lys Gly Met Ile Ser Ile Ile 
    690                 695                 700                 


Ala Ala Val Gln Lys Gln Gln Gln Gln Ser Gly Asn His Pro Ile Thr 
705                 710                 715                 720 


Val His Cys Ser Ala Gly Ala Gly Arg Thr Gly Thr Phe Cys Ala Leu 
                725                 730                 735     


Ser Thr Val Leu Glu Arg Val Lys Ala Glu Gly Ile Leu Asp Val Phe 
            740                 745                 750         


Gln Thr Val Lys Ser Leu Arg Leu Gln Arg Pro His Met Val Gln Thr 
        755                 760                 765             


Leu Glu Gln Tyr Glu Phe Cys Tyr Lys Val Val Gln Glu Tyr Ile Asp 
    770                 775                 780                 


Ala Phe Ser Asp Tyr Ala Asn Phe Lys 
785                 790             


<210>  5639
<211>  368
<212>  PRT
<213>  Homo sapiens

<400>  5639

Met Ala Asn Ser Thr Gly Leu Asn Ala Ser Glu Val Ala Gly Ser Leu 
1               5                   10                  15      


Gly Leu Ile Leu Ala Ala Val Val Glu Val Gly Ala Leu Leu Gly Asn 
            20                  25                  30          


Gly Ala Leu Leu Val Val Val Leu Arg Thr Pro Gly Leu Arg Asp Ala 
        35                  40                  45              


Leu Tyr Leu Ala His Leu Cys Val Val Asp Leu Leu Ala Ala Ala Ser 
    50                  55                  60                  


Ile Met Pro Leu Gly Leu Leu Ala Ala Pro Pro Pro Gly Leu Gly Arg 
65                  70                  75                  80  


Val Arg Leu Gly Pro Ala Pro Cys Arg Ala Ala Arg Phe Leu Ser Ala 
                85                  90                  95      


Ala Leu Leu Pro Ala Cys Thr Leu Gly Val Ala Ala Leu Gly Leu Ala 
            100                 105                 110         


Arg Tyr Arg Leu Ile Val His Pro Leu Arg Pro Gly Ser Arg Pro Pro 
        115                 120                 125             


Pro Val Leu Val Leu Thr Ala Val Trp Ala Ala Ala Gly Leu Leu Gly 
    130                 135                 140                 


Ala Leu Ser Leu Leu Gly Thr Pro Pro Ala Pro Pro Pro Ala Pro Ala 
145                 150                 155                 160 


Arg Cys Ser Val Leu Ala Gly Gly Leu Gly Pro Phe Arg Pro Leu Trp 
                165                 170                 175     


Ala Leu Leu Ala Phe Ala Leu Pro Ala Leu Leu Leu Leu Gly Ala Tyr 
            180                 185                 190         


Gly Gly Ile Phe Val Val Ala Arg Arg Ala Ala Leu Arg Pro Pro Arg 
        195                 200                 205             


Pro Ala Arg Gly Ser Arg Leu His Ser Asp Ser Leu Asp Ser Arg Leu 
    210                 215                 220                 


Ser Ile Leu Pro Pro Leu Arg Pro Arg Leu Pro Gly Gly Lys Ala Ala 
225                 230                 235                 240 


Leu Ala Pro Ala Leu Ala Val Gly Gln Phe Ala Ala Cys Trp Leu Pro 
                245                 250                 255     


Tyr Gly Cys Ala Cys Leu Ala Pro Ala Ala Arg Ala Ala Glu Ala Glu 
            260                 265                 270         


Ala Ala Val Thr Trp Val Ala Tyr Ser Ala Phe Ala Ala His Pro Phe 
        275                 280                 285             


Leu Tyr Gly Leu Leu Gln Arg Pro Val Arg Leu Ala Leu Gly Arg Leu 
    290                 295                 300                 


Ser Arg Arg Ala Leu Pro Gly Pro Val Arg Ala Cys Thr Pro Gln Ala 
305                 310                 315                 320 


Trp His Pro Arg Ala Leu Leu Gln Cys Leu Gln Arg Pro Pro Glu Gly 
                325                 330                 335     


Pro Ala Val Gly Pro Ser Glu Ala Pro Glu Gln Thr Pro Glu Leu Ala 
            340                 345                 350         


Gly Gly Arg Ser Pro Ala Tyr Gln Gly Pro Pro Glu Ser Ser Leu Ser 
        355                 360                 365             


<210>  5640
<211>  553
<212>  PRT
<213>  Homo sapiens

<400>  5640

Met Ala Phe Gln Asp Leu Leu Gly His Ala Gly Asp Leu Trp Arg Phe 
1               5                   10                  15      


Gln Ile Leu Gln Thr Val Phe Leu Ser Ile Phe Ala Val Ala Thr Tyr 
            20                  25                  30          


Leu His Phe Met Leu Glu Asn Phe Thr Ala Phe Ile Pro Gly His Arg 
        35                  40                  45              


Cys Trp Val His Ile Leu Asp Asn Asp Thr Val Ser Asp Asn Asp Thr 
    50                  55                  60                  


Gly Ala Leu Ser Gln Asp Ala Leu Leu Arg Ile Ser Ile Pro Leu Asp 
65                  70                  75                  80  


Ser Asn Met Arg Pro Glu Lys Cys Arg Arg Phe Val His Pro Gln Trp 
                85                  90                  95      


Gln Leu Leu His Leu Asn Gly Thr Phe Pro Asn Thr Ser Asp Ala Asp 
            100                 105                 110         


Met Glu Pro Cys Val Asp Gly Trp Val Tyr Asp Arg Ile Ser Phe Ser 
        115                 120                 125             


Ser Thr Ile Val Thr Glu Trp Asp Leu Val Cys Asp Ser Gln Ser Leu 
    130                 135                 140                 


Thr Ser Val Ala Lys Phe Val Phe Met Ala Gly Met Met Val Gly Gly 
145                 150                 155                 160 


Ile Leu Gly Gly His Leu Ser Asp Arg Phe Gly Arg Arg Phe Val Leu 
                165                 170                 175     


Arg Trp Cys Tyr Leu Gln Val Ala Ile Val Gly Thr Cys Ala Ala Leu 
            180                 185                 190         


Ala Pro Thr Phe Leu Ile Tyr Cys Ser Leu Arg Phe Leu Ser Gly Ile 
        195                 200                 205             


Ala Ala Met Ser Leu Ile Thr Asn Thr Ile Met Leu Ile Ala Glu Trp 
    210                 215                 220                 


Ala Thr His Arg Phe Gln Ala Met Gly Ile Thr Leu Gly Met Cys Pro 
225                 230                 235                 240 


Ser Gly Ile Ala Phe Met Thr Leu Ala Gly Leu Ala Phe Ala Ile Arg 
                245                 250                 255     


Asp Trp His Ile Leu Gln Leu Val Val Ser Val Pro Tyr Phe Val Ile 
            260                 265                 270         


Phe Leu Thr Ser Ser Trp Leu Leu Glu Ser Ala Arg Trp Leu Ile Ile 
        275                 280                 285             


Asn Asn Lys Pro Glu Glu Gly Leu Lys Glu Leu Arg Lys Ala Ala His 
    290                 295                 300                 


Arg Ser Gly Met Lys Asn Ala Arg Asp Thr Leu Thr Leu Glu Ile Leu 
305                 310                 315                 320 


Lys Ser Thr Met Lys Lys Glu Leu Glu Ala Ala Gln Lys Lys Lys Pro 
                325                 330                 335     


Ser Leu Cys Glu Met Leu His Met Pro Asn Ile Cys Lys Arg Ile Ser 
            340                 345                 350         


Leu Leu Ser Phe Thr Arg Phe Ala Asn Phe Met Ala Tyr Phe Gly Leu 
        355                 360                 365             


Asn Leu His Val Gln His Leu Gly Asn Asn Val Phe Leu Leu Gln Thr 
    370                 375                 380                 


Leu Phe Gly Ala Val Ile Leu Leu Ala Asn Cys Val Ala Pro Trp Ala 
385                 390                 395                 400 


Leu Lys Tyr Met Asn Arg Arg Ala Ser Gln Met Leu Leu Met Phe Leu 
                405                 410                 415     


Leu Ala Ile Cys Leu Leu Ala Ile Ile Phe Val Pro Gln Glu Met Gln 
            420                 425                 430         


Thr Leu Arg Glu Val Leu Ala Thr Leu Gly Leu Gly Ala Ser Ala Leu 
        435                 440                 445             


Ala Asn Thr Leu Ala Phe Ala His Gly Asn Glu Val Ile Pro Thr Ile 
    450                 455                 460                 


Ile Arg Ala Arg Ala Met Gly Ile Asn Ala Thr Phe Ala Asn Ile Ala 
465                 470                 475                 480 


Gly Ala Leu Ala Pro Leu Met Met Ile Leu Ser Val Tyr Ser Pro Pro 
                485                 490                 495     


Leu Pro Trp Ile Ile Tyr Gly Val Phe Pro Phe Ile Ser Gly Phe Ala 
            500                 505                 510         


Phe Leu Leu Leu Pro Glu Thr Arg Asn Lys Pro Leu Phe Asp Thr Ile 
        515                 520                 525             


Gln Asp Glu Lys Asn Glu Arg Lys Asp Pro Arg Glu Pro Lys Gln Glu 
    530                 535                 540                 


Asp Pro Arg Val Glu Val Thr Gln Phe 
545                 550             


<210>  5641
<211>  1393
<212>  PRT
<213>  Homo sapiens

<400>  5641

Met Ala Gln Pro Val His Ser Leu Cys Ser Ala Phe Gly Leu Gln Cys 
1               5                   10                  15      


Cys Leu Leu Phe Leu Leu Ala Ser Trp Gly Ala Gly Ala Thr Thr Phe 
            20                  25                  30          


Gln Glu Tyr Gln Lys Thr Gly Glu Leu Ser Thr Ser Asp His Ile Phe 
        35                  40                  45              


Pro Leu Thr Pro Gly Leu Val Tyr Ser Ile Pro Phe Asp His Ile Val 
    50                  55                  60                  


Leu His Ser Gly Gln Arg Pro Pro Glu Leu Pro Lys Ser Thr Glu Ile 
65                  70                  75                  80  


His Glu Gln Lys Arg His Cys Asn Thr Thr Arg His Ser Lys Pro Thr 
                85                  90                  95      


Asp Lys Pro Thr Gly Asn Ser Lys Thr Ile Asp His Lys Ser Ser Thr 
            100                 105                 110         


Asp Asn His Glu Ala Pro Pro Thr Ser Glu Glu Asn Ser Ser Asn Gln 
        115                 120                 125             


Gly Lys Asp Pro Met Ile Arg Asn Gln Arg Ser Val Asp Pro Ala Asp 
    130                 135                 140                 


Ser Thr Thr Thr His Lys Glu Ser Ala Gly Lys Lys His Ile Thr Pro 
145                 150                 155                 160 


Ala Pro Lys Ser Lys Ile Asn Cys Arg Lys Ser Thr Thr Gly Lys Ser 
                165                 170                 175     


Thr Val Thr Arg Lys Ser Asp Lys Thr Gly Arg Pro Leu Glu Lys Ser 
            180                 185                 190         


Met Ser Thr Leu Asp Lys Thr Ser Thr Ser Ser His Lys Thr Thr Thr 
        195                 200                 205             


Ser Phe His Asn Ser Gly Asn Ser Gln Thr Lys Gln Lys Ser Thr Ser 
    210                 215                 220                 


Phe Pro Glu Lys Ile Thr Ala Ala Ser Lys Thr Thr Tyr Lys Thr Thr 
225                 230                 235                 240 


Gly Thr Pro Glu Glu Ser Glu Lys Thr Glu Asp Ser Arg Thr Thr Val 
                245                 250                 255     


Ala Ser Asp Lys Leu Leu Thr Lys Thr Thr Lys Asn Ile Gln Glu Thr 
            260                 265                 270         


Ile Ser Ala Asn Glu Leu Thr Gln Ser Leu Ala Glu Pro Thr Glu His 
        275                 280                 285             


Gly Gly Arg Thr Ala Asn Glu Asn Asn Thr Pro Ser Pro Ala Glu Pro 
    290                 295                 300                 


Thr Glu Asn Arg Glu Arg Thr Ala Asn Glu Asn Thr Thr Leu Ser Pro 
305                 310                 315                 320 


Ala Glu Pro Ile Glu Asn Arg Glu Arg Thr Ala Asn Glu Asn Thr Ala 
                325                 330                 335     


Pro Phe Pro Ala Gly Pro Thr Glu Asn Arg Glu Met Thr Ala Asn Glu 
            340                 345                 350         


Asn Thr Thr Leu Phe Pro Ala Glu Pro Thr Glu His Gly Glu Arg Thr 
        355                 360                 365             


Ala Asn Glu Asn Thr Thr Pro Ser Pro Ala Glu Pro Thr Glu His Gly 
    370                 375                 380                 


Glu Arg Thr Ala Asn Glu Asn Thr Thr Pro Ser Pro Ala Glu Pro Thr 
385                 390                 395                 400 


Glu His Gly Glu Arg Thr Pro Phe Ala Asn Asp Lys Thr Thr Ser Ser 
                405                 410                 415     


Ser Ala Glu Ser Thr Glu His Gly Glu Arg Thr Pro Leu Ala Asn Glu 
            420                 425                 430         


Asn Thr Thr Pro Ser Pro Ala Glu Pro Thr Glu Asn Arg Glu Arg Thr 
        435                 440                 445             


Ala Asn Glu Asn Thr Thr Pro Ser Pro Ala Gly Pro Thr Glu Asn Arg 
    450                 455                 460                 


Glu Thr Thr Ala Asn Glu Lys Thr Thr Leu Ser Pro Val Glu Pro Thr 
465                 470                 475                 480 


Glu Asn Arg Glu Thr Thr Ala Asn Glu Lys Thr Thr Pro Ser Pro Ala 
                485                 490                 495     


Glu Pro Thr Glu Asn Gly Gln Arg Thr Pro Phe Ala Asn Glu Lys Thr 
            500                 505                 510         


Thr Ser Ser Ser Ala Glu Pro Thr Glu His Gly Glu Arg Thr Pro Leu 
        515                 520                 525             


Ala Asn Glu Asn Thr Thr Pro Ser Pro Ala Glu Pro Thr Glu Asn Arg 
    530                 535                 540                 


Glu Arg Thr Ala Asn Glu Lys Thr Thr Pro Ser Pro Ala Glu Pro Thr 
545                 550                 555                 560 


Glu Asn Gly Asp Arg Thr Pro Leu Ala Asn Glu Lys Thr Thr Pro Ser 
                565                 570                 575     


Leu Ala Glu Pro Thr Glu Asn Gly Gln Arg Thr Pro Phe Ala Asn Glu 
            580                 585                 590         


Lys Thr Thr Ser Ser Ser Ala Glu Pro Thr Glu His Glu Glu Arg Thr 
        595                 600                 605             


Pro Leu Ala Asn Glu Asn Thr Thr Pro Ser Pro Ala Glu Pro Thr Glu 
    610                 615                 620                 


Asn Arg Glu Arg Thr Ala Asn Glu Asn Thr Thr Pro Ser Pro Ala Gly 
625                 630                 635                 640 


Pro Thr Glu Asn Arg Glu Met Thr Ala Asn Glu Lys Thr Thr Leu Phe 
                645                 650                 655     


Pro Ala Glu Pro Thr Glu Asn Arg Glu Arg Thr Ala Asn Glu Lys Thr 
            660                 665                 670         


Thr Ser Ser Pro Ala Glu Pro Thr Glu Asn Gly Gln Arg Thr Pro Phe 
        675                 680                 685             


Ala Asn Glu Lys Thr Thr Ser Ser Ser Ala Glu Pro Thr Glu His Gly 
    690                 695                 700                 


Glu Arg Thr Pro Leu Ala Asn Glu Asn Thr Thr Leu Ser Pro Ala Glu 
705                 710                 715                 720 


Pro Thr Glu Asn Arg Glu Arg Thr Ala Asn Glu Lys Thr Thr Pro Phe 
                725                 730                 735     


Pro Ala Glu Pro Thr Glu Asn Arg Glu Arg Thr Ala Asn Glu Asn Thr 
            740                 745                 750         


Thr Pro Ser Pro Ala Gln Pro Thr Glu Asn Gly Asp Arg Thr Pro Leu 
        755                 760                 765             


Ala Asn Glu Lys Thr Thr Pro Ser Leu Ala Glu Pro Thr Glu Asn Gly 
    770                 775                 780                 


Lys Arg Thr Pro Phe Ala Asn Glu Lys Thr Thr Ser Ser Ser Ala Glu 
785                 790                 795                 800 


Pro Thr Glu His Ala Glu Arg Thr Pro Leu Ala Asn Glu Asn Thr Thr 
                805                 810                 815     


Ser Ser Pro Ala Glu Pro Thr Glu Asn Arg Glu Arg Thr Ala Asn Glu 
            820                 825                 830         


Lys Thr Thr Gln Phe Pro Ala Glu Pro Thr Glu Asn Arg Glu Ser Thr 
        835                 840                 845             


Ala Asn Glu Lys Thr Thr Pro Phe Pro Ala Glu Pro Thr Glu Asn Arg 
    850                 855                 860                 


Glu Trp Thr Ala Asn Glu Asn Thr Thr Leu Ser Pro Ala Glu Pro Thr 
865                 870                 875                 880 


Glu His Glu Glu Met Thr Pro Leu Ala Asn Glu Lys Thr Thr Leu Ser 
                885                 890                 895     


Pro Ala Glu Pro Thr Glu Asn Gly Glu Arg Thr Pro Phe Thr Asn Glu 
            900                 905                 910         


Lys Thr Thr Pro Ser Ser Ala Glu Pro Thr Glu His Gly Glu Arg Thr 
        915                 920                 925             


Pro Leu Ala Asn Glu Ile Thr Thr Pro Ser Arg Ala Glu Pro Thr Glu 
    930                 935                 940                 


His Gly Glu Arg Ile Ala Asn Glu Lys Ala Thr Pro Ser Pro Ala Lys 
945                 950                 955                 960 


Pro Thr Glu His Gly Glu Thr Thr Val Asn Glu Asp Thr Thr Pro Ser 
                965                 970                 975     


Ser Ala Glu Pro Thr Glu Asn Gly Glu Arg Thr Pro Leu Ala Asn Glu 
            980                 985                 990         


Asn Thr Thr Thr Ser Pro Thr Glu  Ser Thr Glu His Gly  Glu Arg Thr 
        995                 1000                 1005             


Ala Asn  Glu Lys Thr Thr Pro  Ser Pro Ala Glu Pro  Thr Glu His 
    1010                 1015                 1020             


Gly Glu  Arg Thr Pro Ser Ala  Asn Glu Lys Thr Ile  Pro Ser Pro 
    1025                 1030                 1035             


Ala Lys  Pro Thr Glu His Glu  Glu Met Thr Pro Ser  Ala Asn Glu 
    1040                 1045                 1050             


Asn Thr  Thr Pro Ser Pro Val  Lys Pro Thr Glu His  Gly Glu Lys 
    1055                 1060                 1065             


Thr Thr  Leu Ala Asn Glu Lys  Ile Thr Leu Ser Pro  Glu Gly Pro 
    1070                 1075                 1080             


Thr Glu  His Gly Ala Lys Thr  Thr Ser Ala Asn Glu  Lys Ile Thr 
    1085                 1090                 1095             


Pro Ser  Leu Ala Lys Pro Thr  Glu His Gly Glu Arg  Thr Thr Ser 
    1100                 1105                 1110             


Pro Asn  Asp Lys Ile Thr Ser  Ser Ala Ala Glu Ser  Thr Glu His 
    1115                 1120                 1125             


Arg Asp  Arg Ala Thr Ser Ala  Asn Val Ile Thr Pro  Ala Pro Ala 
    1130                 1135                 1140             


Glu Pro  Ile Lys His Ala Lys  Arg Thr Thr Leu Ala  His Glu Lys 
    1145                 1150                 1155             


Met Thr  Gln Val Thr Glu Lys  Ser Thr Glu His Pro  Glu Lys Thr 
    1160                 1165                 1170             


Thr Ser  Thr Thr Glu Lys Thr  Thr Arg Thr Pro Glu  Lys Pro Thr 
    1175                 1180                 1185             


Leu Tyr  Ser Glu Lys Thr Ile  Cys Thr Lys Gly Lys  Asn Thr Pro 
    1190                 1195                 1200             


Val Pro  Glu Lys Pro Thr Glu  Asn Leu Gly Asn Thr  Thr Leu Thr 
    1205                 1210                 1215             


Thr Glu  Thr Ile Lys Ala Pro  Val Lys Ser Thr Glu  Asn Pro Glu 
    1220                 1225                 1230             


Lys Thr  Ala Ala Val Thr Lys  Thr Ile Lys Pro Ser  Val Lys Val 
    1235                 1240                 1245             


Thr Gly  Asp Lys Ser Leu Thr  Thr Thr Ser Ser His  Leu Asn Lys 
    1250                 1255                 1260             


Thr Glu  Val Thr His Gln Val  Pro Thr Gly Ser Phe  Thr Leu Ile 
    1265                 1270                 1275             


Thr Ser  Arg Thr Lys Leu Ser  Ser Ile Thr Ser Glu  Ala Thr Gly 
    1280                 1285                 1290             


Asn Glu  Ser His Pro Tyr Leu  Asn Lys Asp Gly Ser  Gln Lys Gly 
    1295                 1300                 1305             


Ile His  Ala Gly Gln Met Gly  Glu Asn Asp Ser Phe  Pro Ala Trp 
    1310                 1315                 1320             


Ala Ile  Val Ile Val Val Leu  Val Ala Val Ile Leu  Leu Leu Val 
    1325                 1330                 1335             


Phe Leu  Gly Leu Ile Phe Leu  Val Ser Tyr Met Met  Arg Thr Arg 
    1340                 1345                 1350             


Arg Thr  Leu Thr Gln Asn Thr  Gln Tyr Asn Asp Ala  Glu Asp Glu 
    1355                 1360                 1365             


Gly Gly  Pro Asn Ser Tyr Pro  Val Tyr Leu Met Glu  Gln Gln Asn 
    1370                 1375                 1380             


Leu Gly  Met Gly Gln Ile Pro  Ser Pro Arg 
    1385                 1390             


<210>  5642
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  5642

Met Glu Asp Gly Pro Val Phe Tyr Gly Phe Lys Asn Ile Phe Ile Thr 
1               5                   10                  15      


Met Phe Ala Thr Phe Phe Phe Phe Lys Leu Leu Ile Lys Val Phe Leu 
            20                  25                  30          


Ala Leu Leu Thr His Phe Tyr Ile Val Lys Gly Asn Arg Lys Glu Ala 
        35                  40                  45              


Ala Arg Ile Ala Glu Glu Ile Tyr Gly Gly Ile Ser Asp Cys Trp Ala 
    50                  55                  60                  


Asp Arg Ser Pro Leu His Glu Ala Ala Ala Gln Gly Arg Leu Leu Ala 
65                  70                  75                  80  


Leu Lys Thr Leu Ile Ala Gln Gly Val Asn Val Asn Leu Val Thr Ile 
                85                  90                  95      


Asn Arg Val Ser Ser Leu His Glu Ala Cys Leu Gly Gly His Val Ala 
            100                 105                 110         


Cys Ala Lys Ala Leu Leu Glu Asn Gly Ala His Val Asn Gly Val Thr 
        115                 120                 125             


Val His Gly Ala Thr Pro Leu Phe Asn Ala Cys Cys Ser Gly Ser Ala 
    130                 135                 140                 


Ala Cys Val Asn Val Leu Leu Glu Phe Gly Ala Lys Ala Gln Leu Glu 
145                 150                 155                 160 


Val His Leu Ala Ser Pro Ile His Glu Ala Val Lys Arg Gly His Arg 
                165                 170                 175     


Glu Cys Met Glu Ile Leu Leu Ala Asn Asn Val Asn Ile Asp His Glu 
            180                 185                 190         


Val Pro Gln Leu Gly Thr Pro Leu Tyr Val Ala Cys Thr Tyr Gln Arg 
        195                 200                 205             


Val Asp Cys Val Lys Lys Leu Leu Glu Leu Gly Ala Ser Val Asp His 
    210                 215                 220                 


Gly Gln Trp Leu Asp Thr Pro Leu His Ala Ala Ala Arg Gln Ser Asn 
225                 230                 235                 240 


Val Glu Val Ile His Leu Leu Thr Asp Tyr Gly Ala Asn Leu Lys Arg 
                245                 250                 255     


Arg Asn Ala Gln Gly Lys Ser Ala Leu Asp Leu Ala Ala Pro Lys Ser 
            260                 265                 270         


Ser Val Glu Gln Ala Leu Leu Leu Arg Glu Gly Pro Pro Ala Leu Ser 
        275                 280                 285             


Gln Leu Cys Arg Leu Cys Val Arg Lys Cys Leu Gly Arg Ala Cys His 
    290                 295                 300                 


Gln Ala Ile His Lys Leu His Leu Pro Glu Pro Leu Glu Arg Phe Leu 
305                 310                 315                 320 


Leu Tyr Gln 
            


<210>  5643
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  5643

Met Ser Val Leu Glu Glu Asn Arg Pro Phe Ala Gln Gln Leu Ser Asn 
1               5                   10                  15      


Val Tyr Phe Thr Ile Leu Ser Leu Phe Cys Phe Lys Leu Phe Val Lys 
            20                  25                  30          


Ile Ser Leu Ala Ile Leu Ser His Phe Tyr Ile Val Lys Gly Asn Arg 
        35                  40                  45              


Lys Glu Ala Ala Arg Ile Ala Ala Glu Phe Tyr Gly Val Thr Gln Gly 
    50                  55                  60                  


Gln Gly Ser Trp Ala Asp Arg Ser Pro Leu His Glu Ala Ala Ser Gln 
65                  70                  75                  80  


Gly Arg Leu Leu Ala Leu Arg Thr Leu Leu Ser Gln Gly Tyr Asn Val 
                85                  90                  95      


Asn Ala Val Thr Leu Asp His Val Thr Pro Leu His Glu Ala Cys Leu 
            100                 105                 110         


Gly Asp His Val Ala Cys Ala Arg Thr Leu Leu Glu Ala Gly Ala Asn 
        115                 120                 125             


Val Asn Ala Ile Thr Ile Asp Gly Val Thr Pro Leu Phe Asn Ala Cys 
    130                 135                 140                 


Ser Gln Gly Ser Pro Ser Cys Ala Glu Leu Leu Leu Glu Tyr Gly Ala 
145                 150                 155                 160 


Lys Ala Gln Leu Glu Ser Cys Leu Pro Ser Pro Thr His Glu Ala Ala 
                165                 170                 175     


Ser Lys Gly His His Glu Cys Leu Asp Ile Leu Ile Ser Trp Gly Ile 
            180                 185                 190         


Asp Val Asp Gln Glu Ile Pro His Leu Gly Thr Pro Leu Tyr Val Ala 
        195                 200                 205             


Cys Met Ser Gln Gln Phe His Cys Ile Trp Lys Leu Leu Tyr Ala Gly 
    210                 215                 220                 


Ala Asp Val Gln Lys Gly Lys Tyr Trp Asp Thr Pro Leu His Ala Ala 
225                 230                 235                 240 


Ala Gln Gln Ser Ser Thr Glu Ile Val Asn Leu Leu Leu Glu Phe Gly 
                245                 250                 255     


Ala Asp Ile Asn Ala Lys Asn Thr Glu Leu Leu Arg Pro Ile Asp Val 
            260                 265                 270         


Ala Thr Ser Ser Ser Met Val Glu Arg Ile Leu Leu Gln His Glu Ala 
        275                 280                 285             


Thr Pro Ser Ser Leu Tyr Gln Leu Cys Arg Leu Cys Ile Arg Ser Tyr 
    290                 295                 300                 


Ile Gly Lys Pro Arg Leu His Leu Ile Pro Gln Leu Gln Leu Pro Thr 
305                 310                 315                 320 


Leu Leu Lys Asn Phe Leu Gln Tyr Arg 
                325                 


<210>  5644
<211>  599
<212>  PRT
<213>  Homo sapiens

<400>  5644

Met Pro Ser Ser Leu Pro Gly Ser Gln Val Pro His Pro Thr Leu Asp 
1               5                   10                  15      


Ala Val Asp Leu Val Glu Lys Thr Leu Arg Asn Glu Gly Thr Ser Ser 
            20                  25                  30          


Ser Ala Pro Val Leu Glu Glu Gly Asp Thr Asp Pro Trp Thr Leu Pro 
        35                  40                  45              


Gln Leu Lys Asp Thr Ser Gln Pro Trp Lys Glu Leu Arg Val Ala Gly 
    50                  55                  60                  


Arg Leu Arg Arg Val Ala Gly Ser Val Leu Lys Ala Cys Gly Leu Leu 
65                  70                  75                  80  


Gly Ser Leu Tyr Phe Phe Ile Cys Ser Leu Asp Val Leu Ser Ser Ala 
                85                  90                  95      


Phe Gln Leu Leu Gly Ser Lys Val Ala Gly Asp Ile Phe Lys Asp Asn 
            100                 105                 110         


Val Val Leu Ser Asn Pro Val Ala Gly Leu Val Ile Gly Val Leu Val 
        115                 120                 125             


Thr Ala Leu Val Gln Ser Ser Ser Thr Ser Ser Ser Ile Val Val Ser 
    130                 135                 140                 


Met Val Ala Ala Lys Leu Leu Thr Val Arg Val Ser Val Pro Ile Ile 
145                 150                 155                 160 


Met Gly Val Asn Val Gly Thr Ser Ile Thr Ser Thr Leu Val Ser Met 
                165                 170                 175     


Ala Gln Ser Gly Asp Arg Asp Glu Phe Gln Arg Ala Phe Ser Gly Ser 
            180                 185                 190         


Ala Val His Gly Ile Phe Asn Trp Leu Thr Val Leu Val Leu Leu Pro 
        195                 200                 205             


Leu Glu Ser Ala Thr Ala Leu Leu Glu Arg Leu Ser Glu Leu Ala Leu 
    210                 215                 220                 


Gly Ala Ala Ser Leu Thr Pro Arg Ala Gln Ala Pro Asp Ile Leu Lys 
225                 230                 235                 240 


Val Leu Thr Lys Pro Leu Thr His Leu Ile Val Gln Leu Asp Ser Asp 
                245                 250                 255     


Met Ile Met Ser Ser Ala Thr Gly Asn Ala Thr Asn Ser Ser Leu Ile 
            260                 265                 270         


Lys His Trp Cys Gly Thr Thr Gly Gln Pro Thr Gln Glu Asn Ser Ser 
        275                 280                 285             


Cys Gly Ala Phe Gly Pro Cys Thr Glu Lys Asn Ser Thr Ala Pro Ala 
    290                 295                 300                 


Asp Arg Leu Pro Cys Arg His Leu Phe Ala Gly Thr Glu Leu Thr Asp 
305                 310                 315                 320 


Leu Ala Val Gly Cys Ile Leu Leu Ala Gly Ser Leu Leu Val Leu Cys 
                325                 330                 335     


Gly Cys Leu Val Leu Ile Val Lys Leu Leu Asn Ser Val Leu Arg Gly 
            340                 345                 350         


Arg Val Ala Gln Val Val Arg Thr Val Ile Asn Ala Asp Phe Pro Phe 
        355                 360                 365             


Pro Leu Gly Trp Leu Gly Gly Tyr Leu Ala Val Leu Ala Gly Ala Gly 
    370                 375                 380                 


Leu Thr Phe Ala Leu Gln Ser Ser Ser Val Phe Thr Ala Ala Val Val 
385                 390                 395                 400 


Pro Leu Met Gly Val Gly Val Ile Ser Leu Asp Arg Ala Tyr Pro Leu 
                405                 410                 415     


Leu Leu Gly Ser Asn Ile Gly Thr Thr Thr Thr Ala Leu Leu Ala Ala 
            420                 425                 430         


Leu Ala Ser Pro Ala Asp Arg Met Leu Ser Ala Leu Gln Val Ala Leu 
        435                 440                 445             


Ile His Phe Phe Phe Asn Leu Ala Gly Ile Leu Leu Trp Tyr Leu Val 
    450                 455                 460                 


Pro Ala Leu Arg Leu Pro Ile Pro Leu Ala Arg His Phe Gly Val Val 
465                 470                 475                 480 


Thr Ala Arg Tyr Arg Trp Val Ala Gly Val Tyr Leu Leu Leu Gly Phe 
                485                 490                 495     


Leu Leu Leu Pro Leu Ala Ala Phe Gly Leu Ser Leu Ala Gly Gly Met 
            500                 505                 510         


Val Leu Ala Ala Val Gly Gly Pro Leu Val Gly Leu Val Leu Leu Val 
        515                 520                 525             


Ile Leu Val Thr Val Leu Gln Arg Arg Arg Pro Ala Trp Leu Pro Val 
    530                 535                 540                 


Arg Leu Arg Ser Trp Ala Trp Leu Pro Val Trp Leu His Ser Leu Glu 
545                 550                 555                 560 


Pro Trp Asp Arg Leu Val Thr Arg Cys Cys Pro Cys Asn Val Cys Ser 
                565                 570                 575     


Pro Pro Lys Ala Thr Thr Lys Glu Ala Tyr Cys Tyr Glu Asn Pro Glu 
            580                 585                 590         


Ile Leu Ala Ser Gln Gln Leu 
        595                 


<210>  5645
<211>  1145
<212>  PRT
<213>  Homo sapiens

<400>  5645

Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 
1               5                   10                  15      


Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 
            20                  25                  30          


Thr Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser 
        35                  40                  45              


Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser Lys 
    50                  55                  60                  


Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr 
65                  70                  75                  80  


Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu Asn 
                85                  90                  95      


Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn Leu 
            100                 105                 110         


Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr 
        115                 120                 125             


Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu Lys 
    130                 135                 140                 


Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr Ile 
145                 150                 155                 160 


Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn 
                165                 170                 175     


Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys Glu 
            180                 185                 190         


Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp Ser 
        195                 200                 205             


Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile Ile 
    210                 215                 220                 


Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg 
225                 230                 235                 240 


Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln Arg 
                245                 250                 255     


Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys Asp 
            260                 265                 270         


Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn Leu 
        275                 280                 285             


Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile Ala 
    290                 295                 300                 


Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr Lys 
305                 310                 315                 320 


Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr Ser 
                325                 330                 335     


Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn Gly 
            340                 345                 350         


Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val 
        355                 360                 365             


Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu Gln 
    370                 375                 380                 


Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp Tyr 
385                 390                 395                 400 


Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser Lys 
                405                 410                 415     


Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala 
            420                 425                 430         


Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser 
        435                 440                 445             


Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys 
    450                 455                 460                 


Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr 
465                 470                 475                 480 


Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe 
                485                 490                 495     


Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg 
            500                 505                 510         


Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr 
        515                 520                 525             


Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser 
    530                 535                 540                 


Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys 
545                 550                 555                 560 


Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp 
                565                 570                 575     


Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg 
            580                 585                 590         


Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met 
        595                 600                 605             


Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln 
    610                 615                 620                 


His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn 
625                 630                 635                 640 


Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr 
                645                 650                 655     


Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys 
            660                 665                 670         


Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile 
        675                 680                 685             


Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly 
    690                 695                 700                 


Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val 
705                 710                 715                 720 


Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln 
                725                 730                 735     


Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn 
            740                 745                 750         


Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu 
        755                 760                 765             


His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu 
    770                 775                 780                 


Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His 
785                 790                 795                 800 


Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val 
                805                 810                 815     


Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met 
            820                 825                 830         


Ser Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp Ser 
        835                 840                 845             


Asp Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met Ser 
    850                 855                 860                 


Tyr Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys Glu 
865                 870                 875                 880 


Thr Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys Val 
                885                 890                 895     


Ile Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys Ala 
            900                 905                 910         


Gln Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val Asp 
        915                 920                 925             


Leu Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe Glu 
    930                 935                 940                 


Leu Arg His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr Gln 
945                 950                 955                 960 


Tyr Thr Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu Leu 
                965                 970                 975     


Ile Ser Met Ile Gln Val Val Lys Gln Lys Leu Pro Gln Lys Asn Ser 
            980                 985                 990         


Ser Glu Gly Asn Lys His His Lys  Ser Thr Pro Leu Leu  Ile His Cys 
        995                 1000                 1005             


Arg Asp  Gly Ser Gln Gln Thr  Gly Ile Phe Cys Ala  Leu Leu Asn 
    1010                 1015                 1020             


Leu Leu  Glu Ser Ala Glu Thr  Glu Glu Val Val Asp  Ile Phe Gln 
    1025                 1030                 1035             


Val Val  Lys Ala Leu Arg Lys  Ala Arg Pro Gly Met  Val Ser Thr 
    1040                 1045                 1050             


Phe Glu  Gln Tyr Gln Phe Leu  Tyr Asp Val Ile Ala  Ser Thr Tyr 
    1055                 1060                 1065             


Pro Ala  Gln Asn Gly Gln Val  Lys Lys Asn Asn His  Gln Glu Asp 
    1070                 1075                 1080             


Lys Ile  Glu Phe Asp Asn Glu  Val Asp Lys Val Lys  Gln Asp Ala 
    1085                 1090                 1095             


Asn Cys  Val Asn Pro Leu Gly  Ala Pro Glu Lys Leu  Pro Glu Ala 
    1100                 1105                 1110             


Lys Glu  Gln Ala Glu Gly Ser  Glu Pro Thr Ser Gly  Thr Glu Gly 
    1115                 1120                 1125             


Pro Glu  His Ser Val Asn Gly  Pro Ala Ser Pro Ala  Leu Asn Gln 
    1130                 1135                 1140             


Gly Ser  
    1145 


<210>  5646
<211>  1145
<212>  PRT
<213>  Homo sapiens

<400>  5646

Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 
1               5                   10                  15      


Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 
            20                  25                  30          


Thr Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser 
        35                  40                  45              


Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser Lys 
    50                  55                  60                  


Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr 
65                  70                  75                  80  


Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu Asn 
                85                  90                  95      


Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn Leu 
            100                 105                 110         


Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr 
        115                 120                 125             


Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu Lys 
    130                 135                 140                 


Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr Ile 
145                 150                 155                 160 


Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn 
                165                 170                 175     


Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys Glu 
            180                 185                 190         


Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp Ser 
        195                 200                 205             


Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile Ile 
    210                 215                 220                 


Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg 
225                 230                 235                 240 


Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln Arg 
                245                 250                 255     


Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys Asp 
            260                 265                 270         


Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn Leu 
        275                 280                 285             


Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile Ala 
    290                 295                 300                 


Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr Lys 
305                 310                 315                 320 


Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr Ser 
                325                 330                 335     


Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn Gly 
            340                 345                 350         


Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val 
        355                 360                 365             


Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu Gln 
    370                 375                 380                 


Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp Tyr 
385                 390                 395                 400 


Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser Lys 
                405                 410                 415     


Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala 
            420                 425                 430         


Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser 
        435                 440                 445             


Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys 
    450                 455                 460                 


Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr 
465                 470                 475                 480 


Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe 
                485                 490                 495     


Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg 
            500                 505                 510         


Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr 
        515                 520                 525             


Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser 
    530                 535                 540                 


Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys 
545                 550                 555                 560 


Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp 
                565                 570                 575     


Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg 
            580                 585                 590         


Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met 
        595                 600                 605             


Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln 
    610                 615                 620                 


His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn 
625                 630                 635                 640 


Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr 
                645                 650                 655     


Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys 
            660                 665                 670         


Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile 
        675                 680                 685             


Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly 
    690                 695                 700                 


Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val 
705                 710                 715                 720 


Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln 
                725                 730                 735     


Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn 
            740                 745                 750         


Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu 
        755                 760                 765             


His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu 
    770                 775                 780                 


Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His 
785                 790                 795                 800 


Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val 
                805                 810                 815     


Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met 
            820                 825                 830         


Ser Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp Ser 
        835                 840                 845             


Asp Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met Ser 
    850                 855                 860                 


Tyr Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys Glu 
865                 870                 875                 880 


Thr Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys Val 
                885                 890                 895     


Ile Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys Ala 
            900                 905                 910         


Gln Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val Asp 
        915                 920                 925             


Leu Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe Glu 
    930                 935                 940                 


Leu Arg His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr Gln 
945                 950                 955                 960 


Tyr Thr Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu Leu 
                965                 970                 975     


Ile Ser Met Ile Gln Val Val Lys Gln Lys Leu Pro Gln Lys Asn Ser 
            980                 985                 990         


Ser Glu Gly Asn Lys His His Lys  Ser Thr Pro Leu Leu  Ile His Cys 
        995                 1000                 1005             


Arg Asp  Gly Ser Gln Gln Thr  Gly Ile Phe Cys Ala  Leu Leu Asn 
    1010                 1015                 1020             


Leu Leu  Glu Ser Ala Glu Thr  Glu Glu Val Val Asp  Ile Phe Gln 
    1025                 1030                 1035             


Val Val  Lys Ala Leu Arg Lys  Ala Arg Pro Gly Met  Val Ser Thr 
    1040                 1045                 1050             


Phe Glu  Gln Tyr Gln Phe Leu  Tyr Asp Val Ile Ala  Ser Thr Tyr 
    1055                 1060                 1065             


Pro Ala  Gln Asn Gly Gln Val  Lys Lys Asn Asn His  Gln Glu Asp 
    1070                 1075                 1080             


Lys Ile  Glu Phe Asp Asn Glu  Val Asp Lys Val Lys  Gln Asp Ala 
    1085                 1090                 1095             


Asn Cys  Val Asn Pro Leu Gly  Ala Pro Glu Lys Leu  Pro Glu Ala 
    1100                 1105                 1110             


Lys Glu  Gln Ala Glu Gly Ser  Glu Pro Thr Ser Gly  Thr Glu Gly 
    1115                 1120                 1125             


Pro Glu  His Ser Val Asn Gly  Pro Ala Ser Pro Ala  Leu Asn Gln 
    1130                 1135                 1140             


Gly Ser  
    1145 


<210>  5647
<211>  1145
<212>  PRT
<213>  Homo sapiens

<400>  5647

Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 
1               5                   10                  15      


Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 
            20                  25                  30          


Thr Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser 
        35                  40                  45              


Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser Lys 
    50                  55                  60                  


Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr 
65                  70                  75                  80  


Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu Asn 
                85                  90                  95      


Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn Leu 
            100                 105                 110         


Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr 
        115                 120                 125             


Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu Lys 
    130                 135                 140                 


Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr Ile 
145                 150                 155                 160 


Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn 
                165                 170                 175     


Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys Glu 
            180                 185                 190         


Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp Ser 
        195                 200                 205             


Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile Ile 
    210                 215                 220                 


Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg 
225                 230                 235                 240 


Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln Arg 
                245                 250                 255     


Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys Asp 
            260                 265                 270         


Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn Leu 
        275                 280                 285             


Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile Ala 
    290                 295                 300                 


Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr Lys 
305                 310                 315                 320 


Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr Ser 
                325                 330                 335     


Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn Gly 
            340                 345                 350         


Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val 
        355                 360                 365             


Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu Gln 
    370                 375                 380                 


Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp Tyr 
385                 390                 395                 400 


Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser Lys 
                405                 410                 415     


Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala 
            420                 425                 430         


Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser 
        435                 440                 445             


Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys 
    450                 455                 460                 


Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr 
465                 470                 475                 480 


Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe 
                485                 490                 495     


Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg 
            500                 505                 510         


Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr 
        515                 520                 525             


Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser 
    530                 535                 540                 


Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys 
545                 550                 555                 560 


Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp 
                565                 570                 575     


Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg 
            580                 585                 590         


Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met 
        595                 600                 605             


Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln 
    610                 615                 620                 


His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn 
625                 630                 635                 640 


Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr 
                645                 650                 655     


Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys 
            660                 665                 670         


Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile 
        675                 680                 685             


Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly 
    690                 695                 700                 


Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val 
705                 710                 715                 720 


Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln 
                725                 730                 735     


Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn 
            740                 745                 750         


Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu 
        755                 760                 765             


His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu 
    770                 775                 780                 


Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His 
785                 790                 795                 800 


Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val 
                805                 810                 815     


Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met 
            820                 825                 830         


Ser Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp Ser 
        835                 840                 845             


Asp Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met Ser 
    850                 855                 860                 


Tyr Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys Glu 
865                 870                 875                 880 


Thr Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys Val 
                885                 890                 895     


Ile Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys Ala 
            900                 905                 910         


Gln Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val Asp 
        915                 920                 925             


Leu Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe Glu 
    930                 935                 940                 


Leu Arg His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr Gln 
945                 950                 955                 960 


Tyr Thr Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu Leu 
                965                 970                 975     


Ile Ser Met Ile Gln Val Val Lys Gln Lys Leu Pro Gln Lys Asn Ser 
            980                 985                 990         


Ser Glu Gly Asn Lys His His Lys  Ser Thr Pro Leu Leu  Ile His Cys 
        995                 1000                 1005             


Arg Asp  Gly Ser Gln Gln Thr  Gly Ile Phe Cys Ala  Leu Leu Asn 
    1010                 1015                 1020             


Leu Leu  Glu Ser Ala Glu Thr  Glu Glu Val Val Asp  Ile Phe Gln 
    1025                 1030                 1035             


Val Val  Lys Ala Leu Arg Lys  Ala Arg Pro Gly Met  Val Ser Thr 
    1040                 1045                 1050             


Phe Glu  Gln Tyr Gln Phe Leu  Tyr Asp Val Ile Ala  Ser Thr Tyr 
    1055                 1060                 1065             


Pro Ala  Gln Asn Gly Gln Val  Lys Lys Asn Asn His  Gln Glu Asp 
    1070                 1075                 1080             


Lys Ile  Glu Phe Asp Asn Glu  Val Asp Lys Val Lys  Gln Asp Ala 
    1085                 1090                 1095             


Asn Cys  Val Asn Pro Leu Gly  Ala Pro Glu Lys Leu  Pro Glu Ala 
    1100                 1105                 1110             


Lys Glu  Gln Ala Glu Gly Ser  Glu Pro Thr Ser Gly  Thr Glu Gly 
    1115                 1120                 1125             


Pro Glu  His Ser Val Asn Gly  Pro Ala Ser Pro Ala  Leu Asn Gln 
    1130                 1135                 1140             


Gly Ser  
    1145 


<210>  5648
<211>  775
<212>  PRT
<213>  Homo sapiens

<400>  5648

Met Ala Ser Arg Ala Val Val Arg Ala Arg Arg Cys Pro Gln Cys Pro 
1               5                   10                  15      


Gln Val Arg Ala Ala Ala Ala Ala Pro Ala Trp Ala Ala Leu Pro Leu 
            20                  25                  30          


Ser Arg Ser Leu Pro Pro Cys Ser Asn Ser Ser Ser Phe Ser Met Pro 
        35                  40                  45              


Leu Phe Leu Leu Leu Leu Leu Val Leu Leu Leu Leu Leu Glu Asp Ala 
    50                  55                  60                  


Gly Ala Gln Gln Gly Asp Gly Cys Gly His Thr Val Leu Gly Pro Glu 
65                  70                  75                  80  


Ser Gly Thr Leu Thr Ser Ile Asn Tyr Pro Gln Thr Tyr Pro Asn Ser 
                85                  90                  95      


Thr Val Cys Glu Trp Glu Ile Arg Val Lys Met Gly Glu Arg Val Arg 
            100                 105                 110         


Ile Lys Phe Gly Asp Phe Asp Ile Glu Asp Ser Asp Ser Cys His Phe 
        115                 120                 125             


Asn Tyr Leu Arg Ile Tyr Asn Gly Ile Gly Val Ser Arg Thr Glu Ile 
    130                 135                 140                 


Gly Lys Tyr Cys Gly Leu Gly Leu Gln Met Asn His Ser Ile Glu Ser 
145                 150                 155                 160 


Lys Gly Asn Glu Ile Thr Leu Leu Phe Met Ser Gly Ile His Val Ser 
                165                 170                 175     


Gly Arg Gly Phe Leu Ala Ser Tyr Ser Val Ile Asp Lys Gln Asp Leu 
            180                 185                 190         


Ile Thr Cys Leu Asp Thr Ala Ser Asn Phe Leu Glu Pro Glu Phe Ser 
        195                 200                 205             


Lys Tyr Cys Pro Ala Gly Cys Leu Leu Pro Phe Ala Glu Ile Ser Gly 
    210                 215                 220                 


Thr Ile Pro His Gly Tyr Arg Asp Ser Ser Pro Leu Cys Met Ala Gly 
225                 230                 235                 240 


Val His Ala Gly Val Val Ser Asn Thr Leu Gly Gly Gln Ile Ser Val 
                245                 250                 255     


Val Ile Ser Lys Gly Ile Pro Tyr Tyr Glu Ser Ser Leu Ala Asn Asn 
            260                 265                 270         


Val Thr Ser Val Val Gly His Leu Ser Thr Ser Leu Phe Thr Phe Lys 
        275                 280                 285             


Thr Ser Gly Cys Tyr Gly Thr Leu Gly Met Glu Ser Gly Val Ile Ala 
    290                 295                 300                 


Asp Pro Gln Ile Thr Ala Ser Ser Val Leu Glu Trp Thr Asp His Thr 
305                 310                 315                 320 


Gly Gln Glu Asn Ser Trp Lys Pro Lys Lys Ala Arg Leu Lys Lys Pro 
                325                 330                 335     


Gly Pro Pro Trp Ala Ala Phe Ala Thr Asp Glu Tyr Gln Trp Leu Gln 
            340                 345                 350         


Ile Asp Leu Asn Lys Glu Lys Lys Ile Thr Gly Ile Ile Thr Thr Gly 
        355                 360                 365             


Ser Thr Met Val Glu His Asn Tyr Tyr Val Ser Ala Tyr Arg Ile Leu 
    370                 375                 380                 


Tyr Ser Asp Asp Gly Gln Lys Trp Thr Val Tyr Arg Glu Pro Gly Val 
385                 390                 395                 400 


Glu Gln Asp Lys Ile Phe Gln Gly Asn Lys Asp Tyr His Gln Asp Val 
                405                 410                 415     


Arg Asn Asn Phe Leu Pro Pro Ile Ile Ala Arg Phe Ile Arg Val Asn 
            420                 425                 430         


Pro Thr Gln Trp Gln Gln Lys Ile Ala Met Lys Met Glu Leu Leu Gly 
        435                 440                 445             


Cys Gln Phe Ile Pro Lys Gly Arg Pro Pro Lys Leu Thr Gln Pro Pro 
    450                 455                 460                 


Pro Pro Arg Asn Ser Asn Asp Leu Lys Asn Thr Thr Ala Pro Pro Lys 
465                 470                 475                 480 


Ile Ala Lys Gly Arg Ala Pro Lys Phe Thr Gln Pro Leu Gln Pro Arg 
                485                 490                 495     


Ser Ser Asn Glu Phe Pro Ala Gln Thr Glu Gln Thr Thr Ala Ser Pro 
            500                 505                 510         


Asp Ile Arg Asn Thr Thr Val Thr Pro Asn Val Thr Lys Asp Val Ala 
        515                 520                 525             


Leu Ala Ala Val Leu Val Pro Val Leu Val Met Val Leu Thr Thr Leu 
    530                 535                 540                 


Ile Leu Ile Leu Val Cys Ala Trp His Trp Arg Asn Arg Lys Lys Lys 
545                 550                 555                 560 


Thr Glu Gly Thr Tyr Asp Leu Pro Tyr Trp Asp Arg Ala Gly Trp Trp 
                565                 570                 575     


Lys Gly Met Lys Gln Phe Leu Pro Ala Lys Ala Val Asp His Glu Glu 
            580                 585                 590         


Thr Pro Val Arg Tyr Ser Ser Ser Glu Val Asn His Leu Ser Pro Arg 
        595                 600                 605             


Glu Val Thr Thr Val Leu Gln Ala Asp Ser Ala Glu Tyr Ala Gln Pro 
    610                 615                 620                 


Leu Val Gly Gly Ile Val Gly Thr Leu His Gln Arg Ser Thr Phe Lys 
625                 630                 635                 640 


Pro Glu Glu Gly Lys Glu Ala Gly Tyr Ala Asp Leu Asp Pro Tyr Asn 
                645                 650                 655     


Ser Pro Gly Gln Glu Val Tyr His Ala Tyr Ala Glu Pro Leu Pro Ile 
            660                 665                 670         


Thr Gly Pro Glu Tyr Ala Thr Pro Ile Ile Met Asp Met Ser Gly His 
        675                 680                 685             


Pro Thr Thr Ser Val Gly Gln Pro Ser Thr Ser Thr Phe Lys Ala Thr 
    690                 695                 700                 


Gly Asn Gln Pro Pro Pro Leu Val Gly Thr Tyr Asn Thr Leu Leu Ser 
705                 710                 715                 720 


Arg Thr Asp Ser Cys Ser Ser Ala Gln Ala Gln Tyr Asp Thr Pro Lys 
                725                 730                 735     


Ala Gly Lys Pro Gly Leu Pro Ala Pro Asp Glu Leu Val Tyr Gln Val 
            740                 745                 750         


Pro Gln Ser Thr Gln Glu Val Ser Gly Ala Gly Arg Asp Gly Glu Cys 
        755                 760                 765             


Asp Val Phe Lys Glu Ile Leu 
    770                 775 


<210>  5649
<211>  912
<212>  PRT
<213>  Homo sapiens

<400>  5649

Met Val Lys Ala Pro Gln Ser Glu Glu Arg Leu Ala Arg Gly Gly Lys 
1               5                   10                  15      


Glu Asn Asn Ser Val Leu Ala Cys Gly Ala Gln Ala Ser Trp Ser Ile 
            20                  25                  30          


Phe Gly Ala Asp Ala Ala Glu Val Pro Gly Thr Arg Gly His Ser Gln 
        35                  40                  45              


Gln Glu Ala Ala Met Pro His Ile Pro Glu Asp Glu Glu Pro Pro Gly 
    50                  55                  60                  


Glu Pro Gln Ala Ala Gln Ser Pro Ala Gly Gln Gly Pro Pro Ala Ala 
65                  70                  75                  80  


Gly Val Ser Cys Ser Pro Thr Pro Thr Ile Val Leu Thr Gly Asp Ala 
                85                  90                  95      


Thr Ser Pro Glu Gly Glu Thr Asp Lys Asn Leu Ala Asn Arg Val His 
            100                 105                 110         


Ser Pro His Lys Arg Leu Ser His Arg His Leu Lys Val Ser Thr Ala 
        115                 120                 125             


Ser Leu Thr Ser Val Asp Pro Ala Gly His Ile Ile Asp Leu Val Asn 
    130                 135                 140                 


Asp Gln Leu Pro Asp Ile Ser Ile Ser Glu Glu Asp Lys Lys Lys Asn 
145                 150                 155                 160 


Leu Ala Leu Leu Glu Glu Ala Lys Leu Val Ser Glu Arg Phe Leu Thr 
                165                 170                 175     


Arg Arg Gly Arg Lys Ser Arg Ser Ser Pro Gly Asp Ser Pro Ser Ala 
            180                 185                 190         


Val Ser Pro Asn Leu Ser Pro Ser Ala Ser Pro Thr Ser Ser Arg Ser 
        195                 200                 205             


Asn Ser Leu Thr Val Pro Thr Pro Pro Gly Leu Asp Val Cys Ser Gly 
    210                 215                 220                 


Pro Pro Ser Pro Leu Pro Gly Ala Pro Pro Gln Lys Gly Asp Glu Ala 
225                 230                 235                 240 


Asp Val Ser Ser Pro His Pro Gly Glu Pro Asn Val Pro Lys Gly Leu 
                245                 250                 255     


Ala Asp Arg Lys Gln Asn Asp Gln Arg Lys Val Ser Gln Gly Arg Leu 
            260                 265                 270         


Ala Pro Arg Pro Pro Pro Val Glu Lys Ser Lys Glu Ile Ala Ile Glu 
        275                 280                 285             


Gln Lys Glu Asn Phe Asp Pro Leu Gln Tyr Pro Glu Thr Thr Pro Lys 
    290                 295                 300                 


Gly Leu Ala Pro Val Thr Asn Ser Ser Gly Lys Met Ala Leu Asn Ser 
305                 310                 315                 320 


Pro Gln Pro Gly Pro Val Glu Ser Glu Leu Gly Lys Gln Leu Leu Lys 
                325                 330                 335     


Thr Gly Trp Glu Gly Ser Pro Leu Pro Arg Ser Pro Thr Gln Asp Ala 
            340                 345                 350         


Ala Gly Val Gly Pro Pro Ala Ser Gln Gly Arg Gly Pro Ala Gly Glu 
        355                 360                 365             


Pro Met Gly Pro Glu Ala Gly Ser Lys Ala Glu Leu Pro Pro Thr Val 
    370                 375                 380                 


Ser Arg Pro Pro Leu Leu Arg Gly Leu Ser Trp Asp Ser Gly Pro Glu 
385                 390                 395                 400 


Glu Pro Gly Pro Arg Leu Gln Lys Val Leu Ala Lys Leu Pro Leu Ala 
                405                 410                 415     


Glu Glu Glu Lys Arg Phe Ala Gly Lys Ala Gly Gly Lys Leu Ala Lys 
            420                 425                 430         


Ala Pro Gly Leu Lys Asp Phe Gln Ile Gln Val Gln Pro Val Arg Met 
        435                 440                 445             


Gln Lys Leu Thr Lys Leu Arg Glu Glu His Ile Leu Met Arg Asn Gln 
    450                 455                 460                 


Asn Leu Val Gly Leu Lys Leu Pro Asp Leu Ser Glu Ala Ala Glu Gln 
465                 470                 475                 480 


Glu Lys Gly Leu Pro Ser Glu Leu Ser Pro Ala Ile Glu Glu Glu Glu 
                485                 490                 495     


Ser Lys Ser Gly Leu Asp Val Met Pro Asn Ile Ser Asp Val Leu Leu 
            500                 505                 510         


Arg Lys Leu Arg Val His Arg Ser Leu Pro Gly Ser Ala Pro Pro Leu 
        515                 520                 525             


Thr Glu Lys Glu Val Glu Asn Val Phe Val Gln Leu Ser Leu Ala Phe 
    530                 535                 540                 


Arg Asn Asp Ser Tyr Thr Leu Glu Ser Arg Ile Asn Gln Ala Glu Arg 
545                 550                 555                 560 


Glu Arg Asn Leu Thr Glu Glu Asn Thr Glu Lys Glu Leu Glu Asn Phe 
                565                 570                 575     


Lys Ala Ser Ile Thr Ser Ser Ala Ser Leu Trp His His Cys Glu His 
            580                 585                 590         


Arg Glu Thr Tyr Gln Lys Leu Leu Glu Asp Ile Ala Val Leu His Arg 
        595                 600                 605             


Leu Ala Ala Arg Leu Ser Ser Arg Ala Glu Val Val Gly Ala Val Arg 
    610                 615                 620                 


Gln Glu Lys Arg Met Ser Lys Ala Thr Glu Val Met Met Gln Tyr Val 
625                 630                 635                 640 


Glu Asn Leu Lys Arg Thr Tyr Glu Lys Asp His Ala Glu Leu Met Glu 
                645                 650                 655     


Phe Lys Lys Leu Ala Asn Gln Asn Ser Ser Arg Ser Cys Gly Pro Ser 
            660                 665                 670         


Glu Asp Gly Val Pro Arg Thr Ala Arg Ser Met Ser Leu Thr Leu Gly 
        675                 680                 685             


Lys Asn Met Pro Arg Arg Arg Val Ser Val Ala Val Val Pro Lys Phe 
    690                 695                 700                 


Asn Ala Leu Asn Leu Pro Gly Gln Thr Pro Ser Ser Ser Ser Ile Pro 
705                 710                 715                 720 


Ser Leu Pro Ala Leu Ser Glu Ser Pro Asn Gly Lys Gly Ser Leu Pro 
                725                 730                 735     


Val Thr Ser Ala Leu Pro Ala Leu Leu Glu Asn Gly Lys Thr Asn Gly 
            740                 745                 750         


Asp Pro Asp Cys Glu Ala Ser Ala Pro Ala Leu Thr Leu Ser Cys Leu 
        755                 760                 765             


Glu Glu Leu Ser Gln Glu Thr Lys Ala Arg Met Glu Glu Glu Ala Tyr 
    770                 775                 780                 


Ser Lys Gly Phe Gln Glu Gly Leu Lys Lys Thr Lys Glu Leu Gln Asp 
785                 790                 795                 800 


Leu Lys Glu Glu Glu Glu Glu Gln Lys Ser Glu Ser Pro Glu Glu Pro 
                805                 810                 815     


Glu Glu Val Glu Glu Thr Glu Glu Glu Glu Lys Gly Pro Arg Ser Ser 
            820                 825                 830         


Lys Leu Glu Glu Leu Val His Phe Leu Gln Val Met Tyr Pro Lys Leu 
        835                 840                 845             


Cys Gln His Trp Gln Val Ile Trp Met Met Ala Ala Val Met Leu Val 
    850                 855                 860                 


Leu Thr Val Val Leu Gly Leu Tyr Asn Ser Tyr Asn Ser Cys Ala Glu 
865                 870                 875                 880 


Gln Ala Asp Gly Pro Leu Gly Arg Ser Thr Cys Ser Ala Ala Gln Arg 
                885                 890                 895     


Asp Ser Trp Trp Ser Ser Gly Leu Gln His Glu Gln Pro Thr Glu Gln 
            900                 905                 910         


<210>  5650
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  5650

Met Lys Asp Asp Phe Ala Glu Glu Glu Glu Val Gln Ser Phe Gly Tyr 
1               5                   10                  15      


Lys Arg Phe Gly Ile Gln Glu Gly Thr Gln Cys Thr Lys Cys Lys Asn 
            20                  25                  30          


Asn Trp Ala Leu Lys Phe Ser Ile Ile Leu Leu Tyr Ile Leu Cys Ala 
        35                  40                  45              


Leu Leu Thr Ile Thr Val Ala Ile Leu Gly Tyr Lys Val Val Glu Lys 
    50                  55                  60                  


Met Asp Asn Val Thr Gly Gly Met Glu Thr Ser Arg Gln Thr Tyr Asp 
65                  70                  75                  80  


Asp Lys Leu Thr Ala Val Glu Ser Asp Leu Lys Lys Leu Gly Asp Gln 
                85                  90                  95      


Thr Gly Lys Lys Ala Ile Ser Thr Asn Ser Glu Leu Ser Thr Phe Arg 
            100                 105                 110         


Ser Asp Ile Leu Asp Leu Arg Gln Gln Leu Arg Glu Ile Thr Glu Lys 
        115                 120                 125             


Thr Ser Lys Asn Lys Asp Thr Leu Glu Lys Leu Gln Ala Ser Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Arg Gln Ser Gln Leu Lys Glu Thr Leu Glu Asn Asn 
145                 150                 155                 160 


Ser Phe Leu Ile Thr Thr Val Asn Lys Thr Leu Gln Ala Tyr Asn Gly 
                165                 170                 175     


Tyr Val Thr Asn Leu Gln Gln Asp Thr Ser Val Leu Gln Gly Asn Leu 
            180                 185                 190         


Gln Asn Gln Met Tyr Ser His Asn Val Val Ile Met Asn Leu Asn Asn 
        195                 200                 205             


Leu Asn Leu Thr Gln Val Gln Gln Arg Asn Leu Ile Thr Asn Leu Gln 
    210                 215                 220                 


Arg Ser Val Asp Asp Thr Ser Gln Ala Ile Gln Arg Ile Lys Asn Asp 
225                 230                 235                 240 


Phe Gln Asn Leu Gln Gln Val Phe Leu Gln Ala Lys Lys Asp Thr Asp 
                245                 250                 255     


Trp Leu Lys Glu Lys Val Gln Ser Leu Gln Thr Leu Ala Ala Asn Asn 
            260                 265                 270         


Ser Ala Leu Ala Lys Ala Asn Asn Asp Thr Leu Glu Asp Met Asn Ser 
        275                 280                 285             


Gln Leu Asn Ser Phe Thr Gly Gln Met Glu Asn Ile Thr Thr Ile Ser 
    290                 295                 300                 


Gln Ala Asn Glu Gln Asn Leu Lys Asp Leu Gln Asp Leu His Lys Asp 
305                 310                 315                 320 


Ala Glu Asn Arg Thr Ala Ile Lys Phe Asn Gln Leu Glu Glu Arg Phe 
                325                 330                 335     


Gln Leu Phe Glu Thr Asp Ile Val Asn Ile Ile Ser Asn Ile Ser Tyr 
            340                 345                 350         


Thr Ala His His Leu Arg Thr Leu Thr Ser Asn Leu Asn Glu Val Arg 
        355                 360                 365             


Thr Thr Cys Thr Asp Thr Leu Thr Lys His Thr Asp Asp Leu Thr Ser 
    370                 375                 380                 


Leu Asn Asn Thr Leu Ala Asn Ile Arg Leu Asp Ser Val Ser Leu Arg 
385                 390                 395                 400 


Met Gln Gln Asp Leu Met Arg Ser Arg Leu Asp Thr Glu Val Ala Asn 
                405                 410                 415     


Leu Ser Val Ile Met Glu Glu Met Lys Leu Val Asp Ser Lys His Gly 
            420                 425                 430         


Gln Leu Ile Lys Asn Phe Thr Ile Leu Gln Gly Pro Pro Gly Pro Arg 
        435                 440                 445             


Gly Pro Arg Gly Asp Arg Gly Ser Gln Gly Pro Pro Gly Pro Thr Gly 
    450                 455                 460                 


Asn Lys Gly Gln Lys Gly Glu Lys Gly Glu Pro Gly Pro Pro Gly Pro 
465                 470                 475                 480 


Ala Gly Glu Arg Gly Pro Ile Gly Pro Ala Gly Pro Pro Gly Glu Arg 
                485                 490                 495     


Gly Gly Lys Gly Ser Lys Gly Ser Gln Gly Pro Lys Gly Ser Arg Gly 
            500                 505                 510         


Ser Pro Gly Lys Pro Gly Pro Gln Gly Pro Ser Gly Asp Pro Gly Pro 
        515                 520                 525             


Pro Gly Pro Pro Gly Lys Glu Gly Leu Pro Gly Pro Gln Gly Pro Pro 
    530                 535                 540                 


Gly Phe Gln Gly Leu Gln Gly Thr Val Gly Glu Pro Gly Val Pro Gly 
545                 550                 555                 560 


Pro Arg Gly Leu Pro Gly Leu Pro Gly Val Pro Gly Met Pro Gly Pro 
                565                 570                 575     


Lys Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Ala Val Val Pro Leu 
            580                 585                 590         


Ala Leu Gln Asn Glu Pro Thr Pro Ala Pro Glu Asp Asn Gly Cys Pro 
        595                 600                 605             


Pro His Trp Lys Asn Phe Thr Asp Lys Cys Tyr Tyr Phe Ser Val Glu 
    610                 615                 620                 


Lys Glu Ile Phe Glu Asp Ala Lys Leu Phe Cys Glu Asp Lys Ser Ser 
625                 630                 635                 640 


His Leu Val Phe Ile Asn Thr Arg Glu Glu Gln Gln Trp Ile Lys Lys 
                645                 650                 655     


Gln Met Val Gly Arg Glu Ser His Trp Ile Gly Leu Thr Asp Ser Glu 
            660                 665                 670         


Arg Glu Asn Glu Trp Lys Trp Leu Asp Gly Thr Ser Pro Asp Tyr Lys 
        675                 680                 685             


Asn Trp Lys Ala Gly Gln Pro Asp Asn Trp Gly His Gly His Gly Pro 
    690                 695                 700                 


Gly Glu Asp Cys Ala Gly Leu Ile Tyr Ala Gly Gln Trp Asn Asp Phe 
705                 710                 715                 720 


Gln Cys Glu Asp Val Asn Asn Phe Ile Cys Glu Lys Asp Arg Glu Thr 
                725                 730                 735     


Val Leu Ser Ser Ala Leu 
            740         


<210>  5651
<211>  1505
<212>  PRT
<213>  Homo sapiens

<400>  5651

Met Val His Val Ala Arg Leu Leu Leu Leu Leu Leu Thr Phe Phe Leu 
1               5                   10                  15      


Arg Thr Asp Ala Glu Thr Pro Pro Arg Phe Thr Arg Thr Pro Val Asp 
            20                  25                  30          


Gln Thr Gly Val Ser Gly Gly Val Ala Ser Phe Ile Cys Gln Ala Thr 
        35                  40                  45              


Gly Asp Pro Arg Pro Lys Ile Val Trp Asn Lys Lys Gly Lys Lys Val 
    50                  55                  60                  


Ser Asn Gln Arg Phe Glu Val Ile Glu Phe Asp Asp Gly Ser Gly Ser 
65                  70                  75                  80  


Val Leu Arg Ile Gln Pro Leu Arg Thr Pro Arg Asp Glu Ala Ile Tyr 
                85                  90                  95      


Glu Cys Val Ala Ser Asn Asn Val Gly Glu Ile Ser Val Ser Thr Arg 
            100                 105                 110         


Leu Thr Val Leu Arg Glu Asp Gln Ile Pro Arg Gly Phe Pro Thr Ile 
        115                 120                 125             


Asp Met Gly Pro Gln Leu Lys Val Val Glu Arg Thr Arg Thr Ala Thr 
    130                 135                 140                 


Met Leu Cys Ala Ala Ser Gly Asn Pro Asp Pro Glu Ile Thr Trp Phe 
145                 150                 155                 160 


Lys Asp Phe Leu Pro Val Asp Thr Ser Asn Asn Asn Gly Arg Ile Lys 
                165                 170                 175     


Gln Leu Arg Ser Glu Ser Ile Gly Gly Thr Pro Ile Arg Gly Ala Leu 
            180                 185                 190         


Gln Ile Glu Gln Ser Glu Glu Ser Asp Gln Gly Lys Tyr Glu Cys Val 
        195                 200                 205             


Ala Thr Asn Ser Ala Gly Thr Arg Tyr Ser Ala Pro Ala Asn Leu Tyr 
    210                 215                 220                 


Val Arg Glu Leu Arg Glu Val Arg Arg Val Pro Pro Arg Phe Ser Ile 
225                 230                 235                 240 


Pro Pro Thr Asn His Glu Ile Met Pro Gly Gly Ser Val Asn Ile Thr 
                245                 250                 255     


Cys Val Ala Val Gly Ser Pro Met Pro Tyr Val Lys Trp Met Leu Gly 
            260                 265                 270         


Ala Glu Asp Leu Thr Pro Glu Asp Asp Met Pro Ile Gly Arg Asn Val 
        275                 280                 285             


Leu Glu Leu Asn Asp Val Arg Gln Ser Ala Asn Tyr Thr Cys Val Ala 
    290                 295                 300                 


Met Ser Thr Leu Gly Val Ile Glu Ala Ile Ala Gln Ile Thr Val Lys 
305                 310                 315                 320 


Ala Leu Pro Lys Pro Pro Gly Thr Pro Val Val Thr Glu Ser Thr Ala 
                325                 330                 335     


Thr Ser Ile Thr Leu Thr Trp Asp Ser Gly Asn Pro Glu Pro Val Ser 
            340                 345                 350         


Tyr Tyr Ile Ile Gln His Lys Pro Lys Asn Ser Glu Glu Leu Tyr Lys 
        355                 360                 365             


Glu Ile Asp Gly Val Ala Thr Thr Arg Tyr Ser Val Ala Gly Leu Ser 
    370                 375                 380                 


Pro Tyr Ser Asp Tyr Glu Phe Arg Val Val Ala Val Asn Asn Ile Gly 
385                 390                 395                 400 


Arg Gly Pro Pro Ser Glu Pro Val Leu Thr Gln Thr Ser Glu Gln Ala 
                405                 410                 415     


Pro Ser Ser Ala Pro Arg Asp Val Gln Ala Arg Met Leu Ser Ser Thr 
            420                 425                 430         


Thr Ile Leu Val Gln Trp Lys Glu Pro Glu Glu Pro Asn Gly Gln Ile 
        435                 440                 445             


Gln Gly Tyr Arg Val Tyr Tyr Thr Met Asp Pro Thr Gln His Val Asn 
    450                 455                 460                 


Asn Trp Met Lys His Asn Val Ala Asp Ser Gln Ile Thr Thr Ile Gly 
465                 470                 475                 480 


Asn Leu Val Pro Gln Lys Thr Tyr Ser Val Lys Val Leu Ala Phe Thr 
                485                 490                 495     


Ser Ile Gly Asp Gly Pro Leu Ser Ser Asp Ile Gln Val Ile Thr Gln 
            500                 505                 510         


Thr Gly Val Pro Gly Gln Pro Leu Asn Phe Lys Ala Glu Pro Glu Ser 
        515                 520                 525             


Glu Thr Ser Ile Leu Leu Ser Trp Thr Pro Pro Arg Ser Asp Thr Ile 
    530                 535                 540                 


Ala Asn Tyr Glu Leu Val Tyr Lys Asp Gly Glu His Gly Glu Glu Gln 
545                 550                 555                 560 


Arg Ile Thr Ile Glu Pro Gly Thr Ser Tyr Arg Leu Gln Gly Leu Lys 
                565                 570                 575     


Pro Asn Ser Leu Tyr Tyr Phe Arg Leu Ala Ala Arg Ser Pro Gln Gly 
            580                 585                 590         


Leu Gly Ala Ser Thr Ala Glu Ile Ser Ala Arg Thr Met Gln Ser Met 
        595                 600                 605             


Phe Ala Lys Asn Phe His Val Lys Ala Val Met Lys Thr Ser Val Leu 
    610                 615                 620                 


Leu Ser Trp Glu Ile Pro Glu Asn Tyr Asn Ser Ala Met Pro Phe Lys 
625                 630                 635                 640 


Ile Leu Tyr Asp Asp Gly Lys Met Val Glu Glu Val Asp Gly Arg Ala 
                645                 650                 655     


Thr Gln Lys Leu Ile Val Asn Leu Lys Pro Glu Lys Ser Tyr Ser Phe 
            660                 665                 670         


Val Leu Thr Asn Arg Gly Asn Ser Ala Gly Gly Leu Gln His Arg Val 
        675                 680                 685             


Thr Ala Lys Thr Ala Pro Asp Val Leu Arg Thr Lys Pro Ala Phe Ile 
    690                 695                 700                 


Gly Lys Thr Asn Leu Asp Gly Met Ile Thr Val Gln Leu Pro Glu Val 
705                 710                 715                 720 


Pro Ala Asn Glu Asn Ile Lys Gly Tyr Tyr Ile Ile Ile Val Pro Leu 
                725                 730                 735     


Lys Lys Ser Arg Gly Lys Phe Ile Lys Pro Trp Glu Ser Pro Asp Glu 
            740                 745                 750         


Met Glu Leu Asp Glu Leu Leu Lys Glu Ile Ser Arg Lys Arg Arg Ser 
        755                 760                 765             


Ile Arg Tyr Gly Arg Glu Val Glu Leu Lys Pro Tyr Ile Ala Ala His 
    770                 775                 780                 


Phe Asp Val Leu Pro Thr Glu Phe Thr Leu Gly Asp Asp Lys His Tyr 
785                 790                 795                 800 


Gly Gly Phe Thr Asn Lys Gln Leu Gln Ser Gly Gln Glu Tyr Val Phe 
                805                 810                 815     


Phe Val Leu Ala Val Met Glu His Ala Glu Ser Lys Met Tyr Ala Thr 
            820                 825                 830         


Ser Pro Tyr Ser Asp Pro Val Val Ser Met Asp Leu Asp Pro Gln Pro 
        835                 840                 845             


Ile Thr Asp Glu Glu Glu Gly Leu Ile Trp Val Val Gly Pro Val Leu 
    850                 855                 860                 


Ala Val Val Phe Ile Ile Cys Ile Val Ile Ala Ile Leu Leu Tyr Lys 
865                 870                 875                 880 


Ser Lys Pro Asp Arg Lys Arg Ala Glu Ser Asp Ser Arg Lys Ser Ser 
                885                 890                 895     


Ile Pro Asn Asn Lys Glu Ile Pro Ser His His Pro Thr Asp Pro Val 
            900                 905                 910         


Glu Leu Arg Arg Leu Asn Phe Gln Thr Pro Gly Met Ala Ser His Pro 
        915                 920                 925             


Pro Ile Pro Ile Leu Glu Leu Ala Asp His Ile Glu Arg Leu Lys Ala 
    930                 935                 940                 


Asn Asp Asn Leu Lys Phe Ser Gln Glu Tyr Glu Ser Ile Asp Pro Gly 
945                 950                 955                 960 


Gln Gln Phe Thr Trp Glu His Ser Asn Leu Glu Val Asn Lys Pro Lys 
                965                 970                 975     


Asn Arg Tyr Ala Asn Val Ile Ala Tyr Asp His Ser Arg Val Leu Leu 
            980                 985                 990         


Ser Ala Ile Glu Gly Ile Pro Gly  Ser Asp Tyr Val Asn  Ala Asn Tyr 
        995                 1000                 1005             


Ile Asp  Gly Tyr Arg Lys Gln  Asn Ala Tyr Ile Ala  Thr Gln Gly 
    1010                 1015                 1020             


Ser Leu  Pro Glu Thr Phe Gly  Asp Phe Trp Arg Met  Ile Trp Glu 
    1025                 1030                 1035             


Gln Arg  Ser Ala Thr Val Val  Met Met Thr Lys Leu  Glu Glu Arg 
    1040                 1045                 1050             


Ser Arg  Val Lys Cys Asp Gln  Tyr Trp Pro Ser Arg  Gly Thr Glu 
    1055                 1060                 1065             


Thr His  Gly Leu Val Gln Val  Thr Leu Leu Asp Thr  Val Glu Leu 
    1070                 1075                 1080             


Ala Thr  Tyr Cys Val Arg Thr  Phe Ala Leu Tyr Lys  Asn Gly Ser 
    1085                 1090                 1095             


Ser Glu  Lys Arg Glu Val Arg  Gln Phe Gln Phe Thr  Ala Trp Pro 
    1100                 1105                 1110             


Asp His  Gly Val Pro Glu His  Pro Thr Pro Phe Leu  Ala Phe Leu 
    1115                 1120                 1125             


Arg Arg  Val Lys Thr Cys Asn  Pro Pro Asp Ala Gly  Pro Met Val 
    1130                 1135                 1140             


Val His  Cys Ser Ala Gly Val  Gly Arg Thr Gly Cys  Phe Ile Val 
    1145                 1150                 1155             


Ile Asp  Ala Met Leu Glu Arg  Ile Lys His Glu Lys  Thr Val Asp 
    1160                 1165                 1170             


Ile Tyr  Gly His Val Thr Leu  Met Arg Ala Gln Arg  Asn Tyr Met 
    1175                 1180                 1185             


Val Gln  Thr Glu Asp Gln Tyr  Ile Phe Ile His Asp  Ala Leu Leu 
    1190                 1195                 1200             


Glu Ala  Val Thr Cys Gly Asn  Thr Glu Val Pro Ala  Arg Asn Leu 
    1205                 1210                 1215             


Tyr Ala  Tyr Ile Gln Lys Leu  Thr Gln Ile Glu Thr  Gly Glu Asn 
    1220                 1225                 1230             


Val Thr  Gly Met Glu Leu Glu  Phe Lys Arg Leu Ala  Ser Ser Lys 
    1235                 1240                 1245             


Ala His  Thr Ser Arg Phe Ile  Ser Ala Asn Leu Pro  Cys Asn Lys 
    1250                 1255                 1260             


Phe Lys  Asn Arg Leu Val Asn  Ile Met Pro Tyr Glu  Ser Thr Arg 
    1265                 1270                 1275             


Val Cys  Leu Gln Pro Ile Arg  Gly Val Glu Gly Ser  Asp Tyr Ile 
    1280                 1285                 1290             


Asn Ala  Ser Phe Ile Asp Gly  Tyr Arg Gln Gln Lys  Ala Tyr Ile 
    1295                 1300                 1305             


Ala Thr  Gln Gly Pro Leu Ala  Glu Thr Thr Glu Asp  Phe Trp Arg 
    1310                 1315                 1320             


Met Leu  Trp Glu His Asn Ser  Thr Ile Val Val Met  Leu Thr Lys 
    1325                 1330                 1335             


Leu Arg  Glu Met Gly Arg Glu  Lys Cys His Gln Tyr  Trp Pro Ala 
    1340                 1345                 1350             


Glu Arg  Ser Ala Arg Tyr Gln  Tyr Phe Val Val Asp  Pro Met Ala 
    1355                 1360                 1365             


Glu Tyr  Asn Met Pro Gln Tyr  Ile Leu Arg Glu Phe  Lys Val Thr 
    1370                 1375                 1380             


Asp Ala  Arg Asp Gly Gln Ser  Arg Thr Val Arg Gln  Phe Gln Phe 
    1385                 1390                 1395             


Thr Asp  Trp Pro Glu Gln Gly  Val Pro Lys Ser Gly  Glu Gly Phe 
    1400                 1405                 1410             


Ile Asp  Phe Ile Gly Gln Val  His Lys Thr Lys Glu  Gln Phe Gly 
    1415                 1420                 1425             


Gln Asp  Gly Pro Ile Ser Val  His Cys Ser Ala Gly  Val Gly Arg 
    1430                 1435                 1440             


Thr Gly  Val Phe Ile Thr Leu  Ser Ile Val Leu Glu  Arg Met Arg 
    1445                 1450                 1455             


Tyr Glu  Gly Val Val Asp Ile  Phe Gln Thr Val Lys  Met Leu Arg 
    1460                 1465                 1470             


Thr Gln  Arg Pro Ala Met Val  Gln Thr Glu Asp Gln  Tyr Gln Phe 
    1475                 1480                 1485             


Ser Tyr  Arg Ala Ala Leu Glu  Tyr Leu Gly Ser Phe  Asp His Tyr 
    1490                 1495                 1500             


Ala Thr  
    1505 


<210>  5652
<211>  1506
<212>  PRT
<213>  Homo sapiens

<400>  5652

Met Val His Val Ala Arg Leu Leu Leu Leu Leu Leu Thr Phe Phe Leu 
1               5                   10                  15      


Arg Thr Asp Ala Glu Thr Pro Pro Arg Phe Thr Arg Thr Pro Val Asp 
            20                  25                  30          


Gln Thr Gly Val Ser Gly Gly Val Ala Ser Phe Ile Cys Gln Ala Thr 
        35                  40                  45              


Gly Asp Pro Arg Pro Lys Ile Val Trp Asn Lys Lys Gly Lys Lys Val 
    50                  55                  60                  


Ser Asn Gln Arg Phe Glu Val Ile Glu Phe Asp Asp Gly Ser Gly Ser 
65                  70                  75                  80  


Val Leu Arg Ile Gln Pro Leu Arg Thr Pro Arg Asp Glu Ala Ile Tyr 
                85                  90                  95      


Glu Cys Val Ala Ser Asn Asn Val Gly Glu Ile Ser Val Ser Thr Arg 
            100                 105                 110         


Leu Thr Val Leu Arg Glu Asp Gln Ile Pro Arg Gly Phe Pro Thr Ile 
        115                 120                 125             


Asp Met Gly Pro Gln Leu Lys Val Val Glu Arg Thr Arg Thr Ala Thr 
    130                 135                 140                 


Met Leu Cys Ala Ala Ser Gly Asn Pro Asp Pro Glu Ile Thr Trp Phe 
145                 150                 155                 160 


Lys Asp Phe Leu Pro Val Asp Thr Ser Asn Asn Asn Gly Arg Ile Lys 
                165                 170                 175     


Gln Leu Arg Ser Glu Ser Ile Gly Gly Thr Pro Ile Arg Gly Ala Leu 
            180                 185                 190         


Gln Ile Glu Gln Ser Glu Glu Ser Asp Gln Gly Lys Tyr Glu Cys Val 
        195                 200                 205             


Ala Thr Asn Ser Ala Gly Thr Arg Tyr Ser Ala Pro Ala Asn Leu Tyr 
    210                 215                 220                 


Val Arg Glu Leu Arg Glu Val Arg Arg Val Pro Pro Arg Phe Ser Ile 
225                 230                 235                 240 


Pro Pro Thr Asn His Glu Ile Met Pro Gly Gly Ser Val Asn Ile Thr 
                245                 250                 255     


Cys Val Ala Val Gly Ser Pro Met Pro Tyr Val Lys Trp Met Leu Gly 
            260                 265                 270         


Ala Glu Asp Leu Thr Pro Glu Asp Asp Met Pro Ile Gly Arg Asn Val 
        275                 280                 285             


Leu Glu Leu Asn Asp Val Arg Gln Ser Ala Asn Tyr Thr Cys Val Ala 
    290                 295                 300                 


Met Ser Thr Leu Gly Val Ile Glu Ala Ile Ala Gln Ile Thr Val Lys 
305                 310                 315                 320 


Ala Leu Pro Lys Pro Pro Gly Thr Pro Val Val Thr Glu Ser Thr Ala 
                325                 330                 335     


Thr Ser Ile Thr Leu Thr Trp Asp Ser Gly Asn Pro Glu Pro Val Ser 
            340                 345                 350         


Tyr Tyr Ile Ile Gln His Lys Pro Lys Asn Ser Glu Glu Leu Tyr Lys 
        355                 360                 365             


Glu Ile Asp Gly Val Ala Thr Thr Arg Tyr Ser Val Ala Gly Leu Ser 
    370                 375                 380                 


Pro Tyr Ser Asp Tyr Glu Phe Arg Val Val Ala Val Asn Asn Ile Gly 
385                 390                 395                 400 


Arg Gly Pro Pro Ser Glu Pro Val Leu Thr Gln Thr Ser Glu Gln Ala 
                405                 410                 415     


Pro Ser Ser Ala Pro Arg Asp Val Gln Ala Arg Met Leu Ser Ser Thr 
            420                 425                 430         


Thr Ile Leu Val Gln Trp Lys Glu Pro Glu Glu Pro Asn Gly Gln Ile 
        435                 440                 445             


Gln Gly Tyr Arg Val Tyr Tyr Thr Met Asp Pro Thr Gln His Val Asn 
    450                 455                 460                 


Asn Trp Met Lys His Asn Val Ala Asp Ser Gln Ile Thr Thr Ile Gly 
465                 470                 475                 480 


Asn Leu Val Pro Gln Lys Thr Tyr Ser Val Lys Val Leu Ala Phe Thr 
                485                 490                 495     


Ser Ile Gly Asp Gly Pro Leu Ser Ser Asp Ile Gln Val Ile Thr Gln 
            500                 505                 510         


Thr Gly Val Pro Gly Gln Pro Leu Asn Phe Lys Ala Glu Pro Glu Ser 
        515                 520                 525             


Glu Thr Ser Ile Leu Leu Ser Trp Thr Pro Pro Arg Ser Asp Thr Ile 
    530                 535                 540                 


Ala Asn Tyr Glu Leu Val Tyr Lys Asp Gly Glu His Gly Glu Glu Gln 
545                 550                 555                 560 


Arg Ile Thr Ile Glu Pro Gly Thr Ser Tyr Arg Leu Gln Gly Leu Lys 
                565                 570                 575     


Pro Asn Ser Leu Tyr Tyr Phe Arg Leu Ala Ala Arg Ser Pro Gln Gly 
            580                 585                 590         


Leu Gly Ala Ser Thr Ala Glu Ile Ser Ala Arg Thr Met Gln Ser Met 
        595                 600                 605             


Phe Ala Lys Asn Phe His Val Lys Ala Val Met Lys Thr Ser Val Leu 
    610                 615                 620                 


Leu Ser Trp Glu Ile Pro Glu Asn Tyr Asn Ser Ala Met Pro Phe Lys 
625                 630                 635                 640 


Ile Leu Tyr Asp Asp Gly Lys Met Val Glu Glu Val Asp Gly Arg Ala 
                645                 650                 655     


Thr Gln Lys Leu Ile Val Asn Leu Lys Pro Glu Lys Ser Tyr Ser Phe 
            660                 665                 670         


Val Leu Thr Asn Arg Gly Asn Ser Ala Gly Gly Leu Gln His Arg Val 
        675                 680                 685             


Thr Ala Lys Thr Ala Pro Asp Val Leu Arg Thr Lys Pro Ala Phe Ile 
    690                 695                 700                 


Gly Lys Thr Asn Leu Asp Gly Met Ile Thr Val Gln Leu Pro Glu Val 
705                 710                 715                 720 


Pro Ala Asn Glu Asn Ile Lys Gly Tyr Tyr Ile Ile Ile Val Pro Leu 
                725                 730                 735     


Lys Lys Ser Arg Gly Lys Phe Ile Lys Pro Trp Glu Ser Pro Asp Glu 
            740                 745                 750         


Met Glu Leu Asp Glu Leu Leu Lys Glu Ile Ser Arg Lys Arg Arg Ser 
        755                 760                 765             


Ile Arg Tyr Gly Arg Glu Val Glu Leu Lys Pro Tyr Ile Ala Ala His 
    770                 775                 780                 


Phe Asp Val Leu Pro Thr Glu Phe Thr Leu Gly Asp Asp Lys His Tyr 
785                 790                 795                 800 


Gly Gly Phe Thr Asn Lys Gln Leu Gln Ser Gly Gln Glu Tyr Val Phe 
                805                 810                 815     


Phe Val Leu Ala Val Met Glu His Ala Glu Ser Lys Met Tyr Ala Thr 
            820                 825                 830         


Ser Pro Tyr Ser Asp Pro Val Val Ser Met Asp Leu Asp Pro Gln Pro 
        835                 840                 845             


Ile Thr Asp Glu Glu Glu Gly Leu Ile Trp Val Val Gly Pro Val Leu 
    850                 855                 860                 


Ala Val Val Phe Ile Ile Cys Ile Val Ile Ala Ile Leu Leu Tyr Lys 
865                 870                 875                 880 


Ser Ser Lys Pro Asp Arg Lys Arg Ala Glu Ser Asp Ser Arg Lys Ser 
                885                 890                 895     


Ser Ile Pro Asn Asn Lys Glu Ile Pro Ser His His Pro Thr Asp Pro 
            900                 905                 910         


Val Glu Leu Arg Arg Leu Asn Phe Gln Thr Pro Gly Met Ala Ser His 
        915                 920                 925             


Pro Pro Ile Pro Ile Leu Glu Leu Ala Asp His Ile Glu Arg Leu Lys 
    930                 935                 940                 


Ala Asn Asp Asn Leu Lys Phe Ser Gln Glu Tyr Glu Ser Ile Asp Pro 
945                 950                 955                 960 


Gly Gln Gln Phe Thr Trp Glu His Ser Asn Leu Glu Val Asn Lys Pro 
                965                 970                 975     


Lys Asn Arg Tyr Ala Asn Val Ile Ala Tyr Asp His Ser Arg Val Leu 
            980                 985                 990         


Leu Ser Ala Ile Glu Gly Ile Pro  Gly Ser Asp Tyr Val  Asn Ala Asn 
        995                 1000                 1005             


Tyr Ile  Asp Gly Tyr Arg Lys  Gln Asn Ala Tyr Ile  Ala Thr Gln 
    1010                 1015                 1020             


Gly Ser  Leu Pro Glu Thr Phe  Gly Asp Phe Trp Arg  Met Ile Trp 
    1025                 1030                 1035             


Glu Gln  Arg Ser Ala Thr Val  Val Met Met Thr Lys  Leu Glu Glu 
    1040                 1045                 1050             


Arg Ser  Arg Val Lys Cys Asp  Gln Tyr Trp Pro Ser  Arg Gly Thr 
    1055                 1060                 1065             


Glu Thr  His Gly Leu Val Gln  Val Thr Leu Leu Asp  Thr Val Glu 
    1070                 1075                 1080             


Leu Ala  Thr Tyr Cys Val Arg  Thr Phe Ala Leu Tyr  Lys Asn Gly 
    1085                 1090                 1095             


Ser Ser  Glu Lys Arg Glu Val  Arg Gln Phe Gln Phe  Thr Ala Trp 
    1100                 1105                 1110             


Pro Asp  His Gly Val Pro Glu  His Pro Thr Pro Phe  Leu Ala Phe 
    1115                 1120                 1125             


Leu Arg  Arg Val Lys Thr Cys  Asn Pro Pro Asp Ala  Gly Pro Met 
    1130                 1135                 1140             


Val Val  His Cys Ser Ala Gly  Val Gly Arg Thr Gly  Cys Phe Ile 
    1145                 1150                 1155             


Val Ile  Asp Ala Met Leu Glu  Arg Ile Lys His Glu  Lys Thr Val 
    1160                 1165                 1170             


Asp Ile  Tyr Gly His Val Thr  Leu Met Arg Ala Gln  Arg Asn Tyr 
    1175                 1180                 1185             


Met Val  Gln Thr Glu Asp Gln  Tyr Ile Phe Ile His  Asp Ala Leu 
    1190                 1195                 1200             


Leu Glu  Ala Val Thr Cys Gly  Asn Thr Glu Val Pro  Ala Arg Asn 
    1205                 1210                 1215             


Leu Tyr  Ala Tyr Ile Gln Lys  Leu Thr Gln Ile Glu  Thr Gly Glu 
    1220                 1225                 1230             


Asn Val  Thr Gly Met Glu Leu  Glu Phe Lys Arg Leu  Ala Ser Ser 
    1235                 1240                 1245             


Lys Ala  His Thr Ser Arg Phe  Ile Ser Ala Asn Leu  Pro Cys Asn 
    1250                 1255                 1260             


Lys Phe  Lys Asn Arg Leu Val  Asn Ile Met Pro Tyr  Glu Ser Thr 
    1265                 1270                 1275             


Arg Val  Cys Leu Gln Pro Ile  Arg Gly Val Glu Gly  Ser Asp Tyr 
    1280                 1285                 1290             


Ile Asn  Ala Ser Phe Ile Asp  Gly Tyr Arg Gln Gln  Lys Ala Tyr 
    1295                 1300                 1305             


Ile Ala  Thr Gln Gly Pro Leu  Ala Glu Thr Thr Glu  Asp Phe Trp 
    1310                 1315                 1320             


Arg Met  Leu Trp Glu His Asn  Ser Thr Ile Val Val  Met Leu Thr 
    1325                 1330                 1335             


Lys Leu  Arg Glu Met Gly Arg  Glu Lys Cys His Gln  Tyr Trp Pro 
    1340                 1345                 1350             


Ala Glu  Arg Ser Ala Arg Tyr  Gln Tyr Phe Val Val  Asp Pro Met 
    1355                 1360                 1365             


Ala Glu  Tyr Asn Met Pro Gln  Tyr Ile Leu Arg Glu  Phe Lys Val 
    1370                 1375                 1380             


Thr Asp  Ala Arg Asp Gly Gln  Ser Arg Thr Val Arg  Gln Phe Gln 
    1385                 1390                 1395             


Phe Thr  Asp Trp Pro Glu Gln  Gly Val Pro Lys Ser  Gly Glu Gly 
    1400                 1405                 1410             


Phe Ile  Asp Phe Ile Gly Gln  Val His Lys Thr Lys  Glu Gln Phe 
    1415                 1420                 1425             


Gly Gln  Asp Gly Pro Ile Ser  Val His Cys Ser Ala  Gly Val Gly 
    1430                 1435                 1440             


Arg Thr  Gly Val Phe Ile Thr  Leu Ser Ile Val Leu  Glu Arg Met 
    1445                 1450                 1455             


Arg Tyr  Glu Gly Val Val Asp  Ile Phe Gln Thr Val  Lys Met Leu 
    1460                 1465                 1470             


Arg Thr  Gln Arg Pro Ala Met  Val Gln Thr Glu Asp  Gln Tyr Gln 
    1475                 1480                 1485             


Phe Ser  Tyr Arg Ala Ala Leu  Glu Tyr Leu Gly Ser  Phe Asp His 
    1490                 1495                 1500             


Tyr Ala  Thr 
    1505     


<210>  5653
<211>  1496
<212>  PRT
<213>  Homo sapiens

<400>  5653

Met Val His Val Ala Arg Leu Leu Leu Leu Leu Leu Thr Phe Phe Leu 
1               5                   10                  15      


Arg Thr Asp Ala Glu Thr Pro Pro Arg Phe Thr Arg Thr Pro Val Asp 
            20                  25                  30          


Gln Thr Gly Val Ser Gly Gly Val Ala Ser Phe Ile Cys Gln Ala Thr 
        35                  40                  45              


Gly Asp Pro Arg Pro Lys Ile Val Trp Asn Lys Lys Gly Lys Lys Val 
    50                  55                  60                  


Ser Asn Gln Arg Phe Glu Val Ile Glu Phe Asp Asp Gly Ser Gly Ser 
65                  70                  75                  80  


Val Leu Arg Ile Gln Pro Leu Arg Thr Pro Arg Asp Glu Ala Ile Tyr 
                85                  90                  95      


Glu Cys Val Ala Ser Asn Asn Val Gly Glu Ile Ser Val Ser Thr Arg 
            100                 105                 110         


Leu Thr Val Leu Arg Glu Asp Gln Ile Pro Arg Gly Phe Pro Thr Ile 
        115                 120                 125             


Asp Met Gly Pro Gln Leu Lys Val Val Glu Arg Thr Arg Thr Ala Thr 
    130                 135                 140                 


Met Leu Cys Ala Ala Ser Gly Asn Pro Asp Pro Glu Ile Thr Trp Phe 
145                 150                 155                 160 


Lys Asp Phe Leu Pro Val Asp Thr Ser Asn Asn Asn Gly Arg Ile Lys 
                165                 170                 175     


Gln Leu Arg Ser Glu Ser Ile Gly Ala Leu Gln Ile Glu Gln Ser Glu 
            180                 185                 190         


Glu Ser Asp Gln Gly Lys Tyr Glu Cys Val Ala Thr Asn Ser Ala Gly 
        195                 200                 205             


Thr Arg Tyr Ser Ala Pro Ala Asn Leu Tyr Val Arg Glu Leu Arg Glu 
    210                 215                 220                 


Val Arg Arg Val Pro Pro Arg Phe Ser Ile Pro Pro Thr Asn His Glu 
225                 230                 235                 240 


Ile Met Pro Gly Gly Ser Val Asn Ile Thr Cys Val Ala Val Gly Ser 
                245                 250                 255     


Pro Met Pro Tyr Val Lys Trp Met Leu Gly Ala Glu Asp Leu Thr Pro 
            260                 265                 270         


Glu Asp Asp Met Pro Ile Gly Arg Asn Val Leu Glu Leu Asn Asp Val 
        275                 280                 285             


Arg Gln Ser Ala Asn Tyr Thr Cys Val Ala Met Ser Thr Leu Gly Val 
    290                 295                 300                 


Ile Glu Ala Ile Ala Gln Ile Thr Val Lys Ala Leu Pro Lys Pro Pro 
305                 310                 315                 320 


Gly Thr Pro Val Val Thr Glu Ser Thr Ala Thr Ser Ile Thr Leu Thr 
                325                 330                 335     


Trp Asp Ser Gly Asn Pro Glu Pro Val Ser Tyr Tyr Ile Ile Gln His 
            340                 345                 350         


Lys Pro Lys Asn Ser Glu Glu Leu Tyr Lys Glu Ile Asp Gly Val Ala 
        355                 360                 365             


Thr Thr Arg Tyr Ser Val Ala Gly Leu Ser Pro Tyr Ser Asp Tyr Glu 
    370                 375                 380                 


Phe Arg Val Val Ala Val Asn Asn Ile Gly Arg Gly Pro Pro Ser Glu 
385                 390                 395                 400 


Pro Val Leu Thr Gln Thr Ser Glu Gln Ala Pro Ser Ser Ala Pro Arg 
                405                 410                 415     


Asp Val Gln Ala Arg Met Leu Ser Ser Thr Thr Ile Leu Val Gln Trp 
            420                 425                 430         


Lys Glu Pro Glu Glu Pro Asn Gly Gln Ile Gln Gly Tyr Arg Val Tyr 
        435                 440                 445             


Tyr Thr Met Asp Pro Thr Gln His Val Asn Asn Trp Met Lys His Asn 
    450                 455                 460                 


Val Ala Asp Ser Gln Ile Thr Thr Ile Gly Asn Leu Val Pro Gln Lys 
465                 470                 475                 480 


Thr Tyr Ser Val Lys Val Leu Ala Phe Thr Ser Ile Gly Asp Gly Pro 
                485                 490                 495     


Leu Ser Ser Asp Ile Gln Val Ile Thr Gln Thr Gly Val Pro Gly Gln 
            500                 505                 510         


Pro Leu Asn Phe Lys Ala Glu Pro Glu Ser Glu Thr Ser Ile Leu Leu 
        515                 520                 525             


Ser Trp Thr Pro Pro Arg Ser Asp Thr Ile Ala Asn Tyr Glu Leu Val 
    530                 535                 540                 


Tyr Lys Asp Gly Glu His Gly Glu Glu Gln Arg Ile Thr Ile Glu Pro 
545                 550                 555                 560 


Gly Thr Ser Tyr Arg Leu Gln Gly Leu Lys Pro Asn Ser Leu Tyr Tyr 
                565                 570                 575     


Phe Arg Leu Ala Ala Arg Ser Pro Gln Gly Leu Gly Ala Ser Thr Ala 
            580                 585                 590         


Glu Ile Ser Ala Arg Thr Met Gln Ser Thr Val Phe Ala Lys Asn Phe 
        595                 600                 605             


His Val Lys Ala Val Met Lys Thr Ser Val Leu Leu Ser Trp Glu Ile 
    610                 615                 620                 


Pro Glu Asn Tyr Asn Ser Ala Met Pro Phe Lys Ile Leu Tyr Asp Asp 
625                 630                 635                 640 


Gly Lys Met Val Glu Glu Val Asp Gly Arg Ala Thr Gln Lys Leu Ile 
                645                 650                 655     


Val Asn Leu Lys Pro Glu Lys Ser Tyr Ser Phe Val Leu Thr Asn Arg 
            660                 665                 670         


Gly Asn Ser Ala Gly Gly Leu Gln His Arg Val Thr Ala Lys Thr Ala 
        675                 680                 685             


Pro Asp Val Leu Arg Thr Lys Pro Ala Phe Ile Gly Lys Thr Asn Leu 
    690                 695                 700                 


Asp Gly Met Ile Thr Val Gln Leu Pro Glu Val Pro Ala Asn Glu Asn 
705                 710                 715                 720 


Ile Lys Gly Tyr Tyr Ile Ile Ile Val Pro Leu Lys Lys Ser Arg Gly 
                725                 730                 735     


Lys Phe Ile Lys Pro Trp Glu Ser Pro Asp Glu Met Glu Leu Asp Glu 
            740                 745                 750         


Leu Leu Lys Glu Ile Ser Arg Lys Arg Arg Ser Ile Arg Tyr Gly Arg 
        755                 760                 765             


Glu Val Glu Leu Lys Pro Tyr Ile Ala Ala His Phe Asp Val Leu Pro 
    770                 775                 780                 


Thr Glu Phe Thr Leu Gly Asp Asp Lys His Tyr Gly Gly Phe Thr Asn 
785                 790                 795                 800 


Lys Gln Leu Gln Ser Gly Gln Glu Tyr Val Phe Phe Val Leu Ala Val 
                805                 810                 815     


Met Glu His Ala Glu Ser Lys Met Tyr Ala Thr Ser Pro Tyr Ser Asp 
            820                 825                 830         


Pro Val Val Ser Met Asp Leu Asp Pro Gln Pro Ile Thr Asp Glu Glu 
        835                 840                 845             


Glu Gly Leu Ile Trp Val Val Gly Pro Val Leu Ala Val Val Phe Ile 
    850                 855                 860                 


Ile Cys Ile Val Ile Ala Ile Leu Leu Tyr Lys Arg Lys Arg Ala Glu 
865                 870                 875                 880 


Ser Asp Ser Arg Lys Ser Ser Ile Pro Asn Asn Lys Glu Ile Pro Ser 
                885                 890                 895     


His His Pro Thr Asp Pro Val Glu Leu Arg Arg Leu Asn Phe Gln Thr 
            900                 905                 910         


Pro Gly Met Ala Ser His Pro Pro Ile Pro Ile Leu Glu Leu Ala Asp 
        915                 920                 925             


His Ile Glu Arg Leu Lys Ala Asn Asp Asn Leu Lys Phe Ser Gln Glu 
    930                 935                 940                 


Tyr Glu Ser Ile Asp Pro Gly Gln Gln Phe Thr Trp Glu His Ser Asn 
945                 950                 955                 960 


Leu Glu Val Asn Lys Pro Lys Asn Arg Tyr Ala Asn Val Ile Ala Tyr 
                965                 970                 975     


Asp His Ser Arg Val Leu Leu Ser Ala Ile Glu Gly Ile Pro Gly Ser 
            980                 985                 990         


Asp Tyr Val Asn Ala Asn Tyr Ile  Asp Gly Tyr Arg Lys  Gln Asn Ala 
        995                 1000                 1005             


Tyr Ile  Ala Thr Gln Gly Ser  Leu Pro Glu Thr Phe  Gly Asp Phe 
    1010                 1015                 1020             


Trp Arg  Met Ile Trp Glu Gln  Arg Ser Ala Thr Val  Val Met Met 
    1025                 1030                 1035             


Thr Lys  Leu Glu Glu Arg Ser  Arg Val Lys Cys Asp  Gln Tyr Trp 
    1040                 1045                 1050             


Pro Ser  Arg Gly Thr Glu Thr  His Gly Leu Val Gln  Val Thr Leu 
    1055                 1060                 1065             


Leu Asp  Thr Val Glu Leu Ala  Thr Tyr Cys Val Arg  Thr Phe Ala 
    1070                 1075                 1080             


Leu Tyr  Lys Asn Gly Ser Ser  Glu Lys Arg Glu Val  Arg Gln Phe 
    1085                 1090                 1095             


Gln Phe  Thr Ala Trp Pro Asp  His Gly Val Pro Glu  His Pro Thr 
    1100                 1105                 1110             


Pro Phe  Leu Ala Phe Leu Arg  Arg Val Lys Thr Cys  Asn Pro Pro 
    1115                 1120                 1125             


Asp Ala  Gly Pro Met Val Val  His Cys Ser Ala Gly  Val Gly Arg 
    1130                 1135                 1140             


Thr Gly  Cys Phe Ile Val Ile  Asp Ala Met Leu Glu  Arg Ile Lys 
    1145                 1150                 1155             


His Glu  Lys Thr Val Asp Ile  Tyr Gly His Val Thr  Leu Met Arg 
    1160                 1165                 1170             


Ala Gln  Arg Asn Tyr Met Val  Gln Thr Glu Asp Gln  Tyr Ile Phe 
    1175                 1180                 1185             


Ile His  Asp Ala Leu Leu Glu  Ala Val Thr Cys Gly  Asn Thr Glu 
    1190                 1195                 1200             


Val Pro  Ala Arg Asn Leu Tyr  Ala Tyr Ile Gln Lys  Leu Thr Gln 
    1205                 1210                 1215             


Ile Glu  Thr Gly Glu Asn Val  Thr Gly Met Glu Leu  Glu Phe Lys 
    1220                 1225                 1230             


Arg Leu  Ala Ser Ser Lys Ala  His Thr Ser Arg Phe  Ile Ser Ala 
    1235                 1240                 1245             


Asn Leu  Pro Cys Asn Lys Phe  Lys Asn Arg Leu Val  Asn Ile Met 
    1250                 1255                 1260             


Pro Tyr  Glu Ser Thr Arg Val  Cys Leu Gln Pro Ile  Arg Gly Val 
    1265                 1270                 1275             


Glu Gly  Ser Asp Tyr Ile Asn  Ala Ser Phe Ile Asp  Gly Tyr Arg 
    1280                 1285                 1290             


Gln Gln  Lys Ala Tyr Ile Ala  Thr Gln Gly Pro Leu  Ala Glu Thr 
    1295                 1300                 1305             


Thr Glu  Asp Phe Trp Arg Met  Leu Trp Glu His Asn  Ser Thr Ile 
    1310                 1315                 1320             


Val Val  Met Leu Thr Lys Leu  Arg Glu Met Gly Arg  Glu Lys Cys 
    1325                 1330                 1335             


His Gln  Tyr Trp Pro Ala Glu  Arg Ser Ala Arg Tyr  Gln Tyr Phe 
    1340                 1345                 1350             


Val Val  Asp Pro Met Ala Glu  Tyr Asn Met Pro Gln  Tyr Ile Leu 
    1355                 1360                 1365             


Arg Glu  Phe Lys Val Thr Asp  Ala Arg Asp Gly Gln  Ser Arg Thr 
    1370                 1375                 1380             


Val Arg  Gln Phe Gln Phe Thr  Asp Trp Pro Glu Gln  Gly Val Pro 
    1385                 1390                 1395             


Lys Ser  Gly Glu Gly Phe Ile  Asp Phe Ile Gly Gln  Val His Lys 
    1400                 1405                 1410             


Thr Lys  Glu Gln Phe Gly Gln  Asp Gly Pro Ile Ser  Val His Cys 
    1415                 1420                 1425             


Ser Ala  Gly Val Gly Arg Thr  Gly Val Phe Ile Thr  Leu Ser Ile 
    1430                 1435                 1440             


Val Leu  Glu Arg Met Arg Tyr  Glu Gly Val Val Asp  Ile Phe Gln 
    1445                 1450                 1455             


Thr Val  Lys Met Leu Arg Thr  Gln Arg Pro Ala Met  Val Gln Thr 
    1460                 1465                 1470             


Glu Asp  Gln Tyr Gln Phe Ser  Tyr Arg Ala Ala Leu  Glu Tyr Leu 
    1475                 1480                 1485             


Gly Ser  Phe Asp His Tyr Ala  Thr 
    1490                 1495     


<210>  5654
<211>  882
<212>  PRT
<213>  Homo sapiens

<400>  5654

Met Ala Ala Ala Met Glu Thr Glu Gln Leu Gly Val Glu Ile Phe Glu 
1               5                   10                  15      


Thr Ala Asp Cys Glu Glu Asn Ile Glu Ser Gln Asp Arg Pro Lys Leu 
            20                  25                  30          


Glu Pro Phe Tyr Val Glu Arg Tyr Ser Trp Ser Gln Leu Lys Lys Leu 
        35                  40                  45              


Leu Ala Asp Thr Arg Lys Tyr His Gly Tyr Met Met Ala Lys Ala Pro 
    50                  55                  60                  


His Asp Phe Met Phe Val Lys Arg Asn Asp Pro Asp Gly Pro His Ser 
65                  70                  75                  80  


Asp Arg Ile Tyr Tyr Leu Ala Met Ser Gly Glu Asn Arg Glu Asn Thr 
                85                  90                  95      


Leu Phe Tyr Ser Glu Ile Pro Lys Thr Ile Asn Arg Ala Ala Val Leu 
            100                 105                 110         


Met Leu Ser Trp Lys Pro Leu Leu Asp Leu Phe Gln Ala Thr Leu Asp 
        115                 120                 125             


Tyr Gly Met Tyr Ser Arg Glu Glu Glu Leu Leu Arg Glu Arg Lys Arg 
    130                 135                 140                 


Ile Gly Thr Val Gly Ile Ala Ser Tyr Asp Tyr His Gln Gly Ser Gly 
145                 150                 155                 160 


Thr Phe Leu Phe Gln Ala Gly Ser Gly Ile Tyr His Val Lys Asp Gly 
                165                 170                 175     


Gly Pro Gln Gly Phe Thr Gln Gln Pro Leu Arg Pro Asn Leu Val Glu 
            180                 185                 190         


Thr Ser Cys Pro Asn Ile Arg Met Asp Pro Lys Leu Cys Pro Ala Asp 
        195                 200                 205             


Pro Asp Trp Ile Ala Phe Ile His Ser Asn Asp Ile Trp Ile Ser Asn 
    210                 215                 220                 


Ile Val Thr Arg Glu Glu Arg Arg Leu Thr Tyr Val His Asn Glu Leu 
225                 230                 235                 240 


Ala Asn Met Glu Glu Asp Ala Arg Ser Ala Gly Val Ala Thr Phe Val 
                245                 250                 255     


Leu Gln Glu Glu Phe Asp Arg Tyr Ser Gly Tyr Trp Trp Cys Pro Lys 
            260                 265                 270         


Ala Glu Thr Thr Pro Ser Gly Gly Lys Ile Leu Arg Ile Leu Tyr Glu 
        275                 280                 285             


Glu Asn Asp Glu Ser Glu Val Glu Ile Ile His Val Thr Ser Pro Met 
    290                 295                 300                 


Leu Glu Thr Arg Arg Ala Asp Ser Phe Arg Tyr Pro Lys Thr Gly Thr 
305                 310                 315                 320 


Ala Asn Pro Lys Val Thr Phe Lys Met Ser Glu Ile Met Ile Asp Ala 
                325                 330                 335     


Glu Gly Arg Ile Ile Asp Val Ile Asp Lys Glu Leu Ile Gln Pro Phe 
            340                 345                 350         


Glu Ile Leu Phe Glu Gly Val Glu Tyr Ile Ala Arg Ala Gly Trp Thr 
        355                 360                 365             


Pro Glu Gly Lys Tyr Ala Trp Ser Ile Leu Leu Asp Arg Ser Gln Thr 
    370                 375                 380                 


Arg Leu Gln Ile Val Leu Ile Ser Pro Glu Leu Phe Ile Pro Val Glu 
385                 390                 395                 400 


Asp Asp Val Met Glu Arg Gln Arg Leu Ile Glu Ser Val Pro Asp Ser 
                405                 410                 415     


Val Thr Pro Leu Ile Ile Tyr Glu Glu Thr Thr Asp Ile Trp Ile Asn 
            420                 425                 430         


Ile His Asp Ile Phe His Val Phe Pro Gln Ser His Glu Glu Glu Ile 
        435                 440                 445             


Glu Phe Ile Phe Ala Ser Glu Cys Lys Thr Gly Phe Arg His Leu Tyr 
    450                 455                 460                 


Lys Ile Thr Ser Ile Leu Lys Glu Ser Lys Tyr Lys Arg Ser Ser Gly 
465                 470                 475                 480 


Gly Leu Pro Ala Pro Ser Asp Phe Lys Cys Pro Ile Lys Glu Glu Ile 
                485                 490                 495     


Ala Ile Thr Ser Gly Glu Trp Glu Val Leu Gly Arg His Gly Ser Asn 
            500                 505                 510         


Ile Gln Val Asp Glu Val Arg Arg Leu Val Tyr Phe Glu Gly Thr Lys 
        515                 520                 525             


Asp Ser Pro Leu Glu His His Leu Tyr Val Val Ser Tyr Val Asn Pro 
    530                 535                 540                 


Gly Glu Val Thr Arg Leu Thr Asp Arg Gly Tyr Ser His Ser Cys Cys 
545                 550                 555                 560 


Ile Ser Gln His Cys Asp Phe Phe Ile Ser Lys Tyr Ser Asn Gln Lys 
                565                 570                 575     


Asn Pro His Cys Val Ser Leu Tyr Lys Leu Ser Ser Pro Glu Asp Asp 
            580                 585                 590         


Pro Thr Cys Lys Thr Lys Glu Phe Trp Ala Thr Ile Leu Asp Ser Ala 
        595                 600                 605             


Gly Pro Leu Pro Asp Tyr Thr Pro Pro Glu Ile Phe Ser Phe Glu Ser 
    610                 615                 620                 


Thr Thr Gly Phe Thr Leu Tyr Gly Met Leu Tyr Lys Pro His Asp Leu 
625                 630                 635                 640 


Gln Pro Gly Lys Lys Tyr Pro Thr Val Leu Phe Ile Tyr Gly Gly Pro 
                645                 650                 655     


Gln Val Gln Leu Val Asn Asn Arg Phe Lys Gly Val Lys Tyr Phe Arg 
            660                 665                 670         


Leu Asn Thr Leu Ala Ser Leu Gly Tyr Val Val Val Val Ile Asp Asn 
        675                 680                 685             


Arg Gly Ser Cys His Arg Gly Leu Lys Phe Glu Gly Ala Phe Lys Tyr 
    690                 695                 700                 


Lys Met Gly Gln Ile Glu Ile Asp Asp Gln Val Glu Gly Leu Gln Tyr 
705                 710                 715                 720 


Leu Ala Ser Arg Tyr Asp Phe Ile Asp Leu Asp Arg Val Gly Ile His 
                725                 730                 735     


Gly Trp Ser Tyr Gly Gly Tyr Leu Ser Leu Met Ala Leu Met Gln Arg 
            740                 745                 750         


Ser Asp Ile Phe Arg Val Ala Ile Ala Gly Ala Pro Val Thr Leu Trp 
        755                 760                 765             


Ile Phe Tyr Asp Thr Gly Tyr Thr Glu Arg Tyr Met Gly His Pro Asp 
    770                 775                 780                 


Gln Asn Glu Gln Gly Tyr Tyr Leu Gly Ser Val Ala Met Gln Ala Glu 
785                 790                 795                 800 


Lys Phe Pro Ser Glu Pro Asn Arg Leu Leu Leu Leu His Gly Phe Leu 
                805                 810                 815     


Asp Glu Asn Val His Phe Ala His Thr Ser Ile Leu Leu Ser Phe Leu 
            820                 825                 830         


Val Arg Ala Gly Lys Pro Tyr Asp Leu Gln Ile Tyr Pro Gln Glu Arg 
        835                 840                 845             


His Ser Ile Arg Val Pro Glu Ser Gly Glu His Tyr Glu Leu His Leu 
    850                 855                 860                 


Leu His Tyr Leu Gln Glu Asn Leu Gly Ser Arg Ile Ala Ala Leu Lys 
865                 870                 875                 880 


Val Ile 
        


<210>  5655
<211>  642
<212>  PRT
<213>  Homo sapiens

<400>  5655

Met Ser Asn Arg Ser Ser Phe Ser Arg Leu Thr Trp Phe Arg Lys Gln 
1               5                   10                  15      


Arg Lys Ala Val Val Ser Thr Ser Asp Lys Lys Met Pro Asn Gly Ile 
            20                  25                  30          


Leu Glu Glu Gln Glu Gln Gln Arg Val Met Leu Leu Ser Arg Ser Pro 
        35                  40                  45              


Ser Gly Pro Lys Lys Tyr Phe Pro Ile Pro Val Glu His Leu Glu Glu 
    50                  55                  60                  


Glu Ile Arg Ile Arg Ser Ala Asp Asp Cys Lys Gln Phe Arg Glu Glu 
65                  70                  75                  80  


Phe Asn Ser Leu Pro Ser Gly His Ile Gln Gly Thr Phe Glu Leu Ala 
                85                  90                  95      


Asn Lys Glu Glu Asn Arg Glu Lys Asn Arg Tyr Pro Asn Ile Leu Pro 
            100                 105                 110         


Asn Asp His Ser Arg Val Ile Leu Ser Gln Leu Asp Gly Ile Pro Cys 
        115                 120                 125             


Ser Asp Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Tyr Lys Glu Lys Asn 
    130                 135                 140                 


Lys Phe Ile Ala Ala Gln Gly Pro Lys Gln Glu Thr Val Asn Asp Phe 
145                 150                 155                 160 


Trp Arg Met Val Trp Glu Gln Lys Ser Ala Thr Ile Val Met Leu Thr 
                165                 170                 175     


Asn Leu Lys Glu Arg Lys Glu Glu Lys Cys His Gln Tyr Trp Pro Asp 
            180                 185                 190         


Gln Gly Cys Trp Thr Tyr Gly Asn Ile Arg Val Cys Val Glu Asp Cys 
        195                 200                 205             


Val Val Leu Val Asp Tyr Thr Ile Arg Lys Phe Cys Ile Gln Pro Gln 
    210                 215                 220                 


Leu Pro Asp Gly Cys Lys Ala Pro Arg Leu Val Ser Gln Leu His Phe 
225                 230                 235                 240 


Thr Ser Trp Pro Asp Phe Gly Val Pro Phe Thr Pro Ile Gly Met Leu 
                245                 250                 255     


Lys Phe Leu Lys Lys Val Lys Thr Leu Asn Pro Val His Ala Gly Pro 
            260                 265                 270         


Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Phe Ile 
        275                 280                 285             


Val Ile Asp Ala Met Met Ala Met Met His Ala Glu Gln Lys Val Asp 
    290                 295                 300                 


Val Phe Glu Phe Val Ser Arg Ile Arg Asn Gln Arg Pro Gln Met Val 
305                 310                 315                 320 


Gln Thr Asp Met Gln Tyr Thr Phe Ile Tyr Gln Ala Leu Leu Glu Tyr 
                325                 330                 335     


Tyr Leu Tyr Gly Asp Thr Glu Leu Asp Val Ser Ser Leu Glu Lys His 
            340                 345                 350         


Leu Gln Thr Met His Gly Thr Thr Thr His Phe Asp Lys Ile Gly Leu 
        355                 360                 365             


Glu Glu Glu Phe Arg Lys Leu Thr Asn Val Arg Ile Met Lys Glu Asn 
    370                 375                 380                 


Met Arg Thr Gly Asn Leu Pro Ala Asn Met Lys Lys Ala Arg Val Ile 
385                 390                 395                 400 


Gln Ile Ile Pro Tyr Asp Phe Asn Arg Val Ile Leu Ser Met Lys Arg 
                405                 410                 415     


Gly Gln Glu Tyr Thr Asp Tyr Ile Asn Ala Ser Phe Ile Asp Gly Tyr 
            420                 425                 430         


Arg Gln Lys Asp Tyr Phe Ile Ala Thr Gln Gly Pro Leu Ala His Thr 
        435                 440                 445             


Val Glu Asp Phe Trp Arg Met Ile Trp Glu Trp Lys Ser His Thr Ile 
    450                 455                 460                 


Val Met Leu Thr Glu Val Gln Glu Arg Glu Gln Asp Lys Cys Tyr Gln 
465                 470                 475                 480 


Tyr Trp Pro Thr Glu Gly Ser Val Thr His Gly Glu Ile Thr Ile Glu 
                485                 490                 495     


Ile Lys Asn Asp Thr Leu Ser Glu Ala Ile Ser Ile Arg Asp Phe Leu 
            500                 505                 510         


Val Thr Leu Asn Gln Pro Gln Ala Arg Gln Glu Glu Gln Val Arg Val 
        515                 520                 525             


Val Arg Gln Phe His Phe His Gly Trp Pro Glu Ile Gly Ile Pro Ala 
    530                 535                 540                 


Glu Gly Lys Gly Met Ile Asp Leu Ile Ala Ala Val Gln Lys Gln Gln 
545                 550                 555                 560 


Gln Gln Thr Gly Asn His Pro Ile Thr Val His Cys Ser Ala Gly Ala 
                565                 570                 575     


Gly Arg Thr Gly Thr Phe Ile Ala Leu Ser Asn Ile Leu Glu Arg Val 
            580                 585                 590         


Lys Ala Glu Gly Leu Leu Asp Val Phe Gln Ala Val Lys Ser Leu Arg 
        595                 600                 605             


Leu Gln Arg Pro His Met Val Gln Thr Leu Glu Gln Tyr Glu Phe Cys 
    610                 615                 620                 


Tyr Lys Val Val Gln Asp Phe Ile Asp Ile Phe Ser Asp Tyr Ala Asn 
625                 630                 635                 640 


Phe Lys 
        


<210>  5656
<211>  1898
<212>  PRT
<213>  Homo sapiens

<400>  5656

Met Ala Pro Glu Pro Ala Pro Gly Arg Thr Met Val Pro Leu Val Pro 
1               5                   10                  15      


Ala Leu Val Met Leu Gly Leu Val Ala Gly Ala His Gly Asp Ser Lys 
            20                  25                  30          


Pro Val Phe Ile Lys Val Pro Glu Asp Gln Thr Gly Leu Ser Gly Gly 
        35                  40                  45              


Val Ala Ser Phe Val Cys Gln Ala Thr Gly Glu Pro Lys Pro Arg Ile 
    50                  55                  60                  


Thr Trp Met Lys Lys Gly Lys Lys Val Ser Ser Gln Arg Phe Glu Val 
65                  70                  75                  80  


Ile Glu Phe Asp Asp Gly Ala Gly Ser Val Leu Arg Ile Gln Pro Leu 
                85                  90                  95      


Arg Val Gln Arg Asp Glu Ala Ile Tyr Glu Cys Thr Ala Thr Asn Ser 
            100                 105                 110         


Leu Gly Glu Ile Asn Thr Ser Ala Lys Leu Ser Val Leu Glu Glu Glu 
        115                 120                 125             


Gln Leu Pro Pro Gly Phe Pro Ser Ile Asp Met Gly Pro Gln Leu Lys 
    130                 135                 140                 


Val Val Glu Lys Ala Arg Thr Ala Thr Met Leu Cys Ala Ala Gly Gly 
145                 150                 155                 160 


Asn Pro Asp Pro Glu Ile Ser Trp Phe Lys Asp Phe Leu Pro Val Asp 
                165                 170                 175     


Pro Ala Thr Ser Asn Gly Arg Ile Lys Gln Leu Arg Ser Gly Ala Leu 
            180                 185                 190         


Gln Ile Glu Ser Ser Glu Glu Ser Asp Gln Gly Lys Tyr Glu Cys Val 
        195                 200                 205             


Ala Thr Asn Ser Ala Gly Thr Arg Tyr Ser Ala Pro Ala Asn Leu Tyr 
    210                 215                 220                 


Val Arg Val Arg Arg Val Ala Pro Arg Phe Ser Ile Pro Pro Ser Ser 
225                 230                 235                 240 


Gln Glu Val Met Pro Gly Gly Ser Val Asn Leu Thr Cys Val Ala Val 
                245                 250                 255     


Gly Ala Pro Met Pro Tyr Val Lys Trp Met Met Gly Ala Glu Glu Leu 
            260                 265                 270         


Thr Lys Glu Asp Glu Met Pro Val Gly Arg Asn Val Leu Glu Leu Ser 
        275                 280                 285             


Asn Val Val Arg Ser Ala Asn Tyr Thr Cys Val Ala Ile Ser Ser Leu 
    290                 295                 300                 


Gly Met Ile Glu Ala Thr Ala Gln Val Thr Val Lys Ala Leu Pro Lys 
305                 310                 315                 320 


Pro Pro Ile Asp Leu Val Val Thr Glu Thr Thr Ala Thr Ser Val Thr 
                325                 330                 335     


Leu Thr Trp Asp Ser Gly Asn Ser Glu Pro Val Thr Tyr Tyr Gly Ile 
            340                 345                 350         


Gln Tyr Arg Ala Ala Gly Thr Glu Gly Pro Phe Gln Glu Val Asp Gly 
        355                 360                 365             


Val Ala Thr Thr Arg Tyr Ser Ile Gly Gly Leu Ser Pro Phe Ser Glu 
    370                 375                 380                 


Tyr Ala Phe Arg Val Leu Ala Val Asn Ser Ile Gly Arg Gly Pro Pro 
385                 390                 395                 400 


Ser Glu Ala Val Arg Ala Arg Thr Gly Glu Gln Ala Pro Ser Ser Pro 
                405                 410                 415     


Pro Arg Arg Val Gln Ala Arg Met Leu Ser Ala Ser Thr Met Leu Val 
            420                 425                 430         


Gln Trp Glu Pro Pro Glu Glu Pro Asn Gly Leu Val Arg Gly Tyr Arg 
        435                 440                 445             


Val Tyr Tyr Thr Pro Asp Ser Arg Arg Pro Pro Asn Ala Trp His Lys 
    450                 455                 460                 


His Asn Thr Asp Ala Gly Leu Leu Thr Thr Val Gly Ser Leu Leu Pro 
465                 470                 475                 480 


Gly Ile Thr Tyr Ser Leu Arg Val Leu Ala Phe Thr Ala Val Gly Asp 
                485                 490                 495     


Gly Pro Pro Ser Pro Thr Ile Gln Val Lys Thr Gln Gln Gly Val Pro 
            500                 505                 510         


Ala Gln Pro Ala Asp Phe Gln Ala Glu Val Glu Ser Asp Thr Arg Ile 
        515                 520                 525             


Gln Leu Ser Trp Leu Leu Pro Pro Gln Glu Arg Ile Ile Met Tyr Glu 
    530                 535                 540                 


Leu Val Tyr Trp Ala Ala Glu Asp Glu Asp Gln Gln His Lys Val Thr 
545                 550                 555                 560 


Phe Asp Pro Thr Ser Ser Tyr Thr Leu Glu Asp Leu Lys Pro Asp Thr 
                565                 570                 575     


Leu Tyr Arg Phe Gln Leu Ala Ala Arg Ser Asp Met Gly Val Gly Val 
            580                 585                 590         


Phe Thr Pro Thr Ile Glu Ala Arg Thr Ala Gln Ser Thr Pro Ser Ala 
        595                 600                 605             


Pro Pro Gln Lys Val Met Cys Val Ser Met Gly Ser Thr Thr Val Arg 
    610                 615                 620                 


Val Ser Trp Val Pro Pro Pro Ala Asp Ser Arg Asn Gly Val Ile Thr 
625                 630                 635                 640 


Gln Tyr Ser Val Ala Tyr Glu Ala Val Asp Gly Glu Asp Arg Gly Arg 
                645                 650                 655     


His Val Val Asp Gly Ile Ser Arg Glu His Ser Ser Trp Asp Leu Val 
            660                 665                 670         


Gly Leu Glu Lys Trp Thr Glu Tyr Arg Val Trp Val Arg Ala His Thr 
        675                 680                 685             


Asp Val Gly Pro Gly Pro Glu Ser Ser Pro Val Leu Val Arg Thr Asp 
    690                 695                 700                 


Glu Asp Val Pro Ser Gly Pro Pro Arg Lys Val Glu Val Glu Pro Leu 
705                 710                 715                 720 


Asn Ser Thr Ala Val His Val Tyr Trp Lys Leu Pro Val Pro Ser Lys 
                725                 730                 735     


Gln His Gly Gln Ile Arg Gly Tyr Gln Val Thr Tyr Val Arg Leu Glu 
            740                 745                 750         


Asn Gly Glu Pro Arg Gly Leu Pro Ile Ile Gln Asp Val Met Leu Ala 
        755                 760                 765             


Glu Ala Gln Glu Thr Thr Ile Ser Gly Leu Thr Pro Glu Thr Thr Tyr 
    770                 775                 780                 


Ser Val Thr Val Ala Ala Tyr Thr Thr Lys Gly Asp Gly Ala Arg Ser 
785                 790                 795                 800 


Lys Pro Lys Ile Val Thr Thr Thr Gly Ala Val Pro Gly Arg Pro Thr 
                805                 810                 815     


Met Met Ile Ser Thr Thr Ala Met Asn Thr Ala Leu Leu Gln Trp His 
            820                 825                 830         


Pro Pro Lys Glu Leu Pro Gly Glu Leu Leu Gly Tyr Arg Leu Gln Tyr 
        835                 840                 845             


Cys Arg Ala Asp Glu Ala Arg Pro Asn Thr Ile Asp Phe Gly Lys Asp 
    850                 855                 860                 


Asp Gln His Phe Thr Val Thr Gly Leu His Lys Gly Thr Thr Tyr Ile 
865                 870                 875                 880 


Phe Arg Leu Ala Ala Lys Asn Arg Ala Gly Leu Gly Glu Glu Phe Glu 
                885                 890                 895     


Lys Glu Ile Arg Thr Pro Glu Asp Leu Pro Ser Gly Phe Pro Gln Asn 
            900                 905                 910         


Leu His Val Thr Gly Leu Thr Thr Ser Thr Thr Glu Leu Ala Trp Asp 
        915                 920                 925             


Pro Pro Val Leu Ala Glu Arg Asn Gly Arg Ile Ile Ser Tyr Thr Val 
    930                 935                 940                 


Val Phe Arg Asp Ile Asn Ser Gln Gln Glu Leu Gln Asn Ile Thr Thr 
945                 950                 955                 960 


Asp Thr Arg Phe Thr Leu Thr Gly Leu Lys Pro Asp Thr Thr Tyr Asp 
                965                 970                 975     


Ile Lys Val Arg Ala Trp Thr Ser Lys Gly Ser Gly Pro Leu Ser Pro 
            980                 985                 990         


Ser Ile Gln Ser Arg Thr Met Pro  Val Glu Gln Val Phe  Ala Lys Asn 
        995                 1000                 1005             


Phe Arg  Val Ala Ala Ala Met  Lys Thr Ser Val Leu  Leu Ser Trp 
    1010                 1015                 1020             


Glu Val  Pro Asp Ser Tyr Lys  Ser Ala Val Pro Phe  Lys Ile Leu 
    1025                 1030                 1035             


Tyr Asn  Gly Gln Ser Val Glu  Val Asp Gly His Ser  Met Arg Lys 
    1040                 1045                 1050             


Leu Ile  Ala Asp Leu Gln Pro  Asn Thr Glu Tyr Ser  Phe Val Leu 
    1055                 1060                 1065             


Met Asn  Arg Gly Ser Ser Ala  Gly Gly Leu Gln His  Leu Val Ser 
    1070                 1075                 1080             


Ile Arg  Thr Ala Pro Asp Leu  Leu Pro His Lys Pro  Leu Pro Ala 
    1085                 1090                 1095             


Ser Ala  Tyr Ile Glu Asp Gly  Arg Phe Asp Leu Ser  Met Pro His 
    1100                 1105                 1110             


Val Gln  Asp Pro Ser Leu Val  Arg Trp Phe Tyr Ile  Val Val Val 
    1115                 1120                 1125             


Pro Ile  Asp Arg Val Gly Gly  Ser Met Leu Thr Pro  Arg Trp Ser 
    1130                 1135                 1140             


Thr Pro  Glu Glu Leu Glu Leu  Asp Glu Leu Leu Glu  Ala Ile Glu 
    1145                 1150                 1155             


Gln Gly  Gly Glu Glu Gln Arg  Arg Arg Arg Arg Gln  Ala Glu Arg 
    1160                 1165                 1170             


Leu Lys  Pro Tyr Val Ala Ala  Gln Leu Asp Val Leu  Pro Glu Thr 
    1175                 1180                 1185             


Phe Thr  Leu Gly Asp Lys Lys  Asn Tyr Arg Gly Phe  Tyr Asn Arg 
    1190                 1195                 1200             


Pro Leu  Ser Pro Asp Leu Ser  Tyr Gln Cys Phe Val  Leu Ala Ser 
    1205                 1210                 1215             


Leu Lys  Glu Pro Met Asp Gln  Lys Arg Tyr Ala Ser  Ser Pro Tyr 
    1220                 1225                 1230             


Ser Asp  Glu Ile Val Val Gln  Val Thr Pro Ala Gln  Gln Gln Glu 
    1235                 1240                 1245             


Glu Pro  Glu Met Leu Trp Val  Thr Gly Pro Val Leu  Ala Val Ile 
    1250                 1255                 1260             


Leu Ile  Ile Leu Ile Val Ile  Ala Ile Leu Leu Phe  Lys Arg Lys 
    1265                 1270                 1275             


Arg Thr  His Ser Pro Ser Ser  Lys Asp Glu Gln Ser  Ile Gly Leu 
    1280                 1285                 1290             


Lys Asp  Ser Leu Leu Ala His  Ser Ser Asp Pro Val  Glu Met Arg 
    1295                 1300                 1305             


Arg Leu  Asn Tyr Gln Thr Pro  Gly Met Arg Asp His  Pro Pro Ile 
    1310                 1315                 1320             


Pro Ile  Thr Asp Leu Ala Asp  Asn Ile Glu Arg Leu  Lys Ala Asn 
    1325                 1330                 1335             


Asp Gly  Leu Lys Phe Ser Gln  Glu Tyr Glu Ser Ile  Asp Pro Gly 
    1340                 1345                 1350             


Gln Gln  Phe Thr Trp Glu Asn  Ser Asn Leu Glu Val  Asn Lys Pro 
    1355                 1360                 1365             


Lys Asn  Arg Tyr Ala Asn Val  Ile Ala Tyr Asp His  Ser Arg Val 
    1370                 1375                 1380             


Ile Leu  Thr Ser Ile Asp Gly  Val Pro Gly Ser Asp  Tyr Ile Asn 
    1385                 1390                 1395             


Ala Asn  Tyr Ile Asp Gly Tyr  Arg Lys Gln Asn Ala  Tyr Ile Ala 
    1400                 1405                 1410             


Thr Gln  Gly Pro Leu Pro Glu  Thr Met Gly Asp Phe  Trp Arg Met 
    1415                 1420                 1425             


Val Trp  Glu Gln Arg Thr Ala  Thr Val Val Met Met  Thr Arg Leu 
    1430                 1435                 1440             


Glu Glu  Lys Ser Arg Val Lys  Cys Asp Gln Tyr Trp  Pro Ala Arg 
    1445                 1450                 1455             


Gly Thr  Glu Thr Cys Gly Leu  Ile Gln Val Thr Leu  Leu Asp Thr 
    1460                 1465                 1470             


Val Glu  Leu Ala Thr Tyr Thr  Val Arg Thr Phe Ala  Leu His Lys 
    1475                 1480                 1485             


Ser Gly  Ser Ser Glu Lys Arg  Glu Leu Arg Gln Phe  Gln Phe Met 
    1490                 1495                 1500             


Ala Trp  Pro Asp His Gly Val  Pro Glu Tyr Pro Thr  Pro Ile Leu 
    1505                 1510                 1515             


Ala Phe  Leu Arg Arg Val Lys  Ala Cys Asn Pro Leu  Asp Ala Gly 
    1520                 1525                 1530             


Pro Met  Val Val His Cys Ser  Ala Gly Val Gly Arg  Thr Gly Cys 
    1535                 1540                 1545             


Phe Ile  Val Ile Asp Ala Met  Leu Glu Arg Met Lys  His Glu Lys 
    1550                 1555                 1560             


Thr Val  Asp Ile Tyr Gly His  Val Thr Cys Met Arg  Ser Gln Arg 
    1565                 1570                 1575             


Asn Tyr  Met Val Gln Thr Glu  Asp Gln Tyr Val Phe  Ile His Glu 
    1580                 1585                 1590             


Ala Leu  Leu Glu Ala Ala Thr  Cys Gly His Thr Glu  Val Pro Ala 
    1595                 1600                 1605             


Arg Asn  Leu Tyr Ala His Ile  Gln Lys Leu Gly Gln  Val Pro Pro 
    1610                 1615                 1620             


Gly Glu  Ser Val Thr Ala Met  Glu Leu Glu Phe Lys  Leu Leu Ala 
    1625                 1630                 1635             


Ser Ser  Lys Ala His Thr Ser  Arg Phe Ile Ser Ala  Asn Leu Pro 
    1640                 1645                 1650             


Cys Asn  Lys Phe Lys Asn Arg  Leu Val Asn Ile Met  Pro Tyr Glu 
    1655                 1660                 1665             


Leu Thr  Arg Val Cys Leu Gln  Pro Ile Arg Gly Val  Glu Gly Ser 
    1670                 1675                 1680             


Asp Tyr  Ile Asn Ala Ser Phe  Leu Asp Gly Tyr Arg  Gln Gln Lys 
    1685                 1690                 1695             


Ala Tyr  Ile Ala Thr Gln Gly  Pro Leu Ala Glu Ser  Thr Glu Asp 
    1700                 1705                 1710             


Phe Trp  Arg Met Leu Trp Glu  His Asn Ser Thr Ile  Ile Val Met 
    1715                 1720                 1725             


Leu Thr  Lys Leu Arg Glu Met  Gly Arg Glu Lys Cys  His Gln Tyr 
    1730                 1735                 1740             


Trp Pro  Ala Glu Arg Ser Ala  Arg Tyr Gln Tyr Phe  Val Val Asp 
    1745                 1750                 1755             


Pro Met  Ala Glu Tyr Asn Met  Pro Gln Tyr Ile Leu  Arg Glu Phe 
    1760                 1765                 1770             


Lys Val  Thr Asp Ala Arg Asp  Gly Gln Ser Arg Thr  Ile Arg Gln 
    1775                 1780                 1785             


Phe Gln  Phe Thr Asp Trp Pro  Glu Gln Gly Val Pro  Lys Thr Gly 
    1790                 1795                 1800             


Glu Gly  Phe Ile Asp Phe Ile  Gly Gln Val His Lys  Thr Lys Glu 
    1805                 1810                 1815             


Gln Phe  Gly Gln Asp Gly Pro  Ile Thr Val His Cys  Ser Ala Gly 
    1820                 1825                 1830             


Val Gly  Arg Thr Gly Val Phe  Ile Thr Leu Ser Ile  Val Leu Glu 
    1835                 1840                 1845             


Arg Met  Arg Tyr Glu Gly Val  Val Asp Met Phe Gln  Thr Val Lys 
    1850                 1855                 1860             


Thr Leu  Arg Thr Gln Arg Pro  Ala Met Val Gln Thr  Glu Asp Gln 
    1865                 1870                 1875             


Tyr Gln  Leu Cys Tyr Arg Ala  Ala Leu Glu Tyr Leu  Gly Ser Phe 
    1880                 1885                 1890             


Asp His  Tyr Ala Thr 
    1895             


<210>  5657
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  5657

Met Val Pro Glu Glu Glu Pro Gln Asp Arg Glu Lys Gly Leu Trp Trp 
1               5                   10                  15      


Phe Gln Leu Lys Val Trp Ser Met Ala Val Val Ser Ile Leu Leu Leu 
            20                  25                  30          


Ser Val Cys Phe Thr Val Ser Ser Val Val Pro His Asn Phe Met Tyr 
        35                  40                  45              


Ser Lys Thr Val Lys Arg Leu Ser Lys Leu Arg Glu Tyr Gln Gln Tyr 
    50                  55                  60                  


His Pro Ser Leu Thr Cys Val Met Glu Gly Lys Asp Ile Glu Asp Trp 
65                  70                  75                  80  


Ser Cys Cys Pro Thr Pro Trp Thr Ser Phe Gln Ser Ser Cys Tyr Phe 
                85                  90                  95      


Ile Ser Thr Gly Met Gln Ser Trp Thr Lys Ser Gln Lys Asn Cys Ser 
            100                 105                 110         


Val Met Gly Ala Asp Leu Val Val Ile Asn Thr Arg Glu Glu Gln Asp 
        115                 120                 125             


Phe Ile Ile Gln Asn Leu Lys Arg Asn Ser Ser Tyr Phe Leu Gly Leu 
    130                 135                 140                 


Ser Asp Pro Gly Gly Arg Arg His Trp Gln Trp Val Asp Gln Thr Pro 
145                 150                 155                 160 


Tyr Asn Glu Asn Val Thr Phe Trp His Ser Gly Glu Pro Asn Asn Leu 
                165                 170                 175     


Asp Glu Arg Cys Ala Ile Ile Asn Phe Arg Ser Ser Glu Glu Trp Gly 
            180                 185                 190         


Trp Asn Asp Ile His Cys His Val Pro Gln Lys Ser Ile Cys Lys Met 
        195                 200                 205             


Lys Lys Ile Tyr Ile 
    210             


<210>  5658
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  5658

Met Ala Ala Ala Thr Arg Gly Cys Arg Pro Trp Gly Ser Leu Leu Gly 
1               5                   10                  15      


Leu Leu Gly Leu Val Ser Ala Ala Ala Ala Ala Trp Asp Leu Ala Ser 
            20                  25                  30          


Leu Arg Cys Thr Leu Gly Ala Phe Cys Glu Cys Asp Phe Arg Pro Asp 
        35                  40                  45              


Leu Pro Gly Leu Glu Cys Asp Leu Ala Gln His Leu Ala Gly Gln His 
    50                  55                  60                  


Leu Ala Lys Ala Leu Val Val Lys Ala Leu Lys Ala Phe Val Arg Asp 
65                  70                  75                  80  


Pro Ala Pro Thr Lys Pro Leu Val Leu Ser Leu His Gly Trp Thr Gly 
                85                  90                  95      


Thr Gly Lys Ser Tyr Val Ser Ser Leu Leu Ala His Tyr Leu Phe Gln 
            100                 105                 110         


Gly Gly Leu Arg Ser Pro Arg Val His His Phe Ser Pro Val Leu His 
        115                 120                 125             


Phe Pro His Pro Ser His Ile Glu Arg Tyr Lys Lys Asp Leu Lys Ser 
    130                 135                 140                 


Trp Val Gln Gly Asn Leu Thr Ala Cys Gly Arg Ser Leu Phe Leu Phe 
145                 150                 155                 160 


Asp Glu Met Asp Lys Met Pro Pro Gly Leu Met Glu Val Leu Arg Pro 
                165                 170                 175     


Phe Leu Gly Ser Ser Trp Val Val Tyr Gly Thr Asn Tyr Arg Lys Ala 
            180                 185                 190         


Ile Phe Ile Phe Ile Arg Trp Gly Pro Ala Leu Gln Trp Ala Gln Trp 
        195                 200                 205             


Gly Gly His Phe Ser Glu Val Gln Leu Tyr Ser Leu Ser Leu Cys Ser 
    210                 215                 220                 


Gln Gln Asn Pro Val Pro His Gly Leu Ser Trp Ala Phe Pro Val Pro 
225                 230                 235                 240 


Ser Ala Thr Leu Arg Asp Asp Ile Val Ile Pro Pro Gly 
                245                 250             


<210>  5659
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  5659

Met Gly Gly Arg Lys Met Ala Thr Asp Glu Glu Asn Val Tyr Gly Leu 
1               5                   10                  15      


Glu Glu Asn Ala Gln Ser Arg Gln Glu Ser Thr Arg Arg Leu Ile Leu 
            20                  25                  30          


Val Gly Arg Thr Gly Ala Gly Lys Ser Ala Thr Gly Asn Ser Ile Leu 
        35                  40                  45              


Gly Gln Arg Arg Phe Phe Ser Arg Leu Gly Ala Thr Ser Val Thr Arg 
    50                  55                  60                  


Ala Cys Thr Thr Gly Ser Arg Arg Trp Asp Lys Cys His Val Glu Val 
65                  70                  75                  80  


Val Asp Thr Pro Asp Ile Phe Ser Ser Gln Val Ser Lys Thr Asp Pro 
                85                  90                  95      


Gly Cys Glu Glu Arg Gly His Cys Tyr Leu Leu Ser Ala Pro Gly Pro 
            100                 105                 110         


His Ala Leu Leu Leu Val Thr Gln Leu Gly Arg Phe Thr Ala Gln Asp 
        115                 120                 125             


Gln Gln Ala Val Arg Gln Val Arg Asp Met Phe Gly Glu Asp Val Leu 
    130                 135                 140                 


Lys Trp Met Val Ile Val Phe Thr Arg Lys Glu Asp Leu Ala Gly Gly 
145                 150                 155                 160 


Ser Leu His Asp Tyr Val Ser Asn Thr Glu Asn Arg Ala Leu Arg Glu 
                165                 170                 175     


Leu Val Ala Glu Cys Gly Gly Arg Val Cys Ala Phe Asp Asn Arg Ala 
            180                 185                 190         


Thr Gly Arg Glu Gln Glu Ala Gln Val Glu Gln Leu Leu Gly Met Val 
        195                 200                 205             


Glu Gly Leu Val Leu Glu His Lys Gly Ala His Tyr Ser Asn Glu Val 
    210                 215                 220                 


Tyr Glu Leu Ala Gln Val Leu Arg Trp Ala Gly Pro Glu Glu Arg Leu 
225                 230                 235                 240 


Arg Arg Val Ala Glu Arg Val Ala Ala Arg Val Gln Arg Arg Pro Trp 
                245                 250                 255     


Gly Ala Trp Leu Ser Ala Arg Leu Trp Lys Trp Leu Lys Ser Pro Arg 
            260                 265                 270         


Ser Trp Arg Leu Gly Leu Ala Leu Leu Leu Gly Gly Ala Leu Leu Phe 
        275                 280                 285             


Trp Val Leu Leu His Arg Arg Trp Ser Glu Ala Val Ala Glu Val Gly 
    290                 295                 300                 


Pro Asp 
305     


<210>  5660
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  5660

Met Asp Phe Gly Leu Ala Leu Leu Leu Ala Gly Leu Leu Gly Leu Leu 
1               5                   10                  15      


Leu Gly Gln Ser Leu Gln Val Lys Pro Leu Gln Val Glu Pro Pro Glu 
            20                  25                  30          


Pro Val Val Ala Val Ala Leu Gly Ala Ser Arg Gln Leu Thr Cys Arg 
        35                  40                  45              


Leu Ala Cys Ala Asp Arg Gly Ala Ser Val Gln Trp Arg Gly Leu Asp 
    50                  55                  60                  


Thr Ser Leu Gly Ala Val Gln Ser Asp Thr Gly Arg Ser Val Leu Thr 
65                  70                  75                  80  


Val Arg Asn Ala Ser Leu Ser Ala Ala Gly Thr Arg Val Cys Val Gly 
                85                  90                  95      


Ser Cys Gly Gly Arg Thr Phe Gln His Thr Val Gln Leu Leu Val Tyr 
            100                 105                 110         


Ala Phe Pro Asp Gln Leu Thr Val Ser Pro Ala Ala Leu Val Pro Gly 
        115                 120                 125             


Asp Pro Glu Val Ala Cys Thr Ala His Lys Val Thr Pro Val Asp Pro 
    130                 135                 140                 


Asn Ala Leu Ser Phe Ser Leu Leu Val Gly Gly Gln Glu Leu Glu Gly 
145                 150                 155                 160 


Ala Gln Ala Leu Gly Pro Glu Val Gln Glu Glu Glu Glu Glu Pro Gln 
                165                 170                 175     


Gly Asp Glu Asp Val Leu Phe Arg Val Thr Glu Arg Trp Arg Leu Pro 
            180                 185                 190         


Pro Leu Gly Thr Pro Val Pro Pro Ala Leu Tyr Cys Gln Ala Thr Met 
        195                 200                 205             


Arg Leu Pro Gly Leu Glu Leu Ser His Arg Gln Ala Ile Pro Val Leu 
    210                 215                 220                 


His Ser Pro Thr Ser Pro Glu Pro Pro Asp Thr Thr Ser Pro Glu Ser 
225                 230                 235                 240 


Pro Asp Thr Thr Ser Pro Glu Ser Pro Asp Thr Thr Ser Gln Glu Pro 
                245                 250                 255     


Pro Asp Thr Thr Ser Pro Glu Pro Pro Asp Lys Thr Ser Pro Glu Pro 
            260                 265                 270         


Ala Pro Gln Gln Gly Ser Thr His Thr Pro Arg Ser Pro Gly Ser Thr 
        275                 280                 285             


Arg Thr Arg Arg Pro Glu Ile Ser Gln Ala Gly Pro Thr Gln Gly Glu 
    290                 295                 300                 


Val Ile Pro Thr Gly Ser Ser Lys Pro Ala Gly Asp Gln Leu Pro Ala 
305                 310                 315                 320 


Ala Leu Trp Thr Ser Ser Ala Val Leu Gly Leu Leu Leu Leu Ala Leu 
                325                 330                 335     


Pro Thr Tyr His Leu Trp Lys Arg Cys Arg His Leu Ala Glu Asp Asp 
            340                 345                 350         


Thr His Pro Pro Ala Ser Leu Arg Leu Leu Pro Gln Val Ser Ala Trp 
        355                 360                 365             


Ala Gly Leu Arg Gly Thr Gly Gln Val Gly Ile Ser Pro Ser 
    370                 375                 380         


<210>  5661
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  5661

Met Asp Phe Gly Leu Ala Leu Leu Leu Ala Gly Leu Leu Gly Leu Leu 
1               5                   10                  15      


Leu Gly Gln Ser Leu Gln Val Lys Pro Leu Gln Val Glu Pro Pro Glu 
            20                  25                  30          


Pro Val Val Ala Val Ala Leu Gly Ala Ser Arg Gln Leu Thr Cys Arg 
        35                  40                  45              


Leu Ala Cys Ala Asp Arg Gly Ala Ser Val Gln Trp Arg Gly Leu Asp 
    50                  55                  60                  


Thr Ser Leu Gly Ala Val Gln Ser Asp Thr Gly Arg Ser Val Leu Thr 
65                  70                  75                  80  


Val Arg Asn Ala Ser Leu Ser Ala Ala Gly Thr Arg Val Cys Val Gly 
                85                  90                  95      


Ser Cys Gly Gly Arg Thr Phe Gln His Thr Val Gln Leu Leu Val Tyr 
            100                 105                 110         


Ala Phe Pro Asp Gln Leu Thr Val Ser Pro Ala Ala Leu Val Pro Gly 
        115                 120                 125             


Asp Pro Glu Val Ala Cys Thr Ala His Lys Val Thr Pro Val Asp Pro 
    130                 135                 140                 


Asn Ala Leu Ser Phe Ser Leu Leu Val Gly Gly Gln Glu Leu Glu Gly 
145                 150                 155                 160 


Ala Gln Ala Leu Gly Pro Glu Val Gln Glu Glu Glu Glu Glu Pro Gln 
                165                 170                 175     


Gly Asp Glu Asp Val Leu Phe Arg Val Thr Glu Arg Trp Arg Leu Pro 
            180                 185                 190         


Pro Leu Gly Thr Pro Val Pro Pro Ala Leu Tyr Cys Gln Ala Thr Met 
        195                 200                 205             


Arg Leu Pro Gly Leu Glu Leu Ser His Arg Gln Ala Ile Pro Ala Ser 
    210                 215                 220                 


Lys Pro Ala Gly Asp Gln Leu Pro Ala Ala Leu Trp Thr Ser Ser Ala 
225                 230                 235                 240 


Val Leu Gly Leu Leu Leu Leu Ala Leu Pro Thr Tyr His Leu Trp Lys 
                245                 250                 255     


Arg Cys Arg His Leu Ala Glu Asp Asp Thr His Pro Pro Ala Ser Leu 
            260                 265                 270         


Arg Leu Leu Pro Gln Val Ser Ala Trp Ala Gly Leu Arg Gly Thr Gly 
        275                 280                 285             


Gln Val Gly Ile Ser Pro Ser 
    290                 295 


<210>  5662
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  5662

Met Glu Gly Gly Trp Pro Ala Arg Gln Ser Ala Leu Leu Cys Leu Thr 
1               5                   10                  15      


Val Ser Leu Leu Leu Gln Gly Arg Gly Asp Ala Phe Thr Ile Asn Cys 
            20                  25                  30          


Ser Gly Phe Asp Gln His Gly Val Asp Pro Ala Val Phe Gln Ala Val 
        35                  40                  45              


Phe Asp Arg Lys Ala Phe Arg Pro Phe Thr Asn Tyr Ser Ile Pro Thr 
    50                  55                  60                  


Arg Val Asn Ile Ser Phe Thr Leu Ser Ala Ile Leu Gly Val Asp Ala 
65                  70                  75                  80  


Gln Leu Gln Leu Leu Thr Ser Phe Leu Trp Met Asp Leu Val Trp Asp 
                85                  90                  95      


Asn Pro Phe Ile Asn Trp Asn Pro Lys Glu Cys Val Gly Ile Asn Lys 
            100                 105                 110         


Leu Thr Val Leu Ala Glu Asn Leu Trp Leu Pro Asp Ile Phe Ile Val 
        115                 120                 125             


Glu Ser Met Asp Val Asp Gln Thr Pro Ser Gly Leu Thr Ala Tyr Ile 
    130                 135                 140                 


Ser Ser Glu Gly Arg Ile Lys Tyr Asp Lys Pro Met Arg Val Thr Ser 
145                 150                 155                 160 


Ile Cys Asn Leu Asp Ile Phe Tyr Phe Pro Phe Asp Gln Gln Asn Cys 
                165                 170                 175     


Thr Phe Thr Phe Ser Ser Phe Leu Tyr Thr Val Asp Ser Met Leu Leu 
            180                 185                 190         


Gly Met Asp Lys Glu Val Trp Glu Ile Thr Asp Thr Ser Arg Lys Val 
        195                 200                 205             


Ile Gln Thr Gln Gly Glu Trp Glu Leu Leu Gly Ile Asn Lys Ala Thr 
    210                 215                 220                 


Pro Lys Met Ser Met Gly Asn Asn Leu Tyr Asp Gln Ile Met Phe Tyr 
225                 230                 235                 240 


Val Ala Ile Arg Arg Arg Pro Ser Leu Tyr Ile Ile Asn Leu Leu Val 
                245                 250                 255     


Pro Ser Ser Phe Leu Val Ala Ile Asp Ala Leu Ser Phe Tyr Leu Pro 
            260                 265                 270         


Ala Glu Ser Glu Asn Arg Ala Pro Phe Lys Ile Thr Leu Leu Leu Gly 
        275                 280                 285             


Tyr Asn Val Phe Leu Leu Met Met Asn Asp Leu Leu Pro Ala Ser Gly 
    290                 295                 300                 


Thr Pro Leu Ile Ser Val Tyr Phe Ala Leu Cys Leu Ser Leu Met Val 
305                 310                 315                 320 


Val Ser Leu Leu Glu Thr Val Phe Ile Thr Tyr Leu Leu His Val Ala 
                325                 330                 335     


Thr Thr Gln Pro Pro Pro Met Pro Arg Trp Leu His Ser Leu Leu Leu 
            340                 345                 350         


His Cys Thr Ser Pro Gly Arg Cys Cys Pro Thr Ala Pro Gln Lys Gly 
        355                 360                 365             


Asn Lys Gly Leu Gly Leu Thr Leu Thr His Leu Pro Gly Pro Lys Glu 
    370                 375                 380                 


Pro Gly Glu Leu Ala Gly Lys Lys Leu Gly Pro Arg Glu Thr Glu Pro 
385                 390                 395                 400 


Asp Gly Gly Ser Gly Trp Thr Lys Thr Gln Leu Met Glu Leu Trp Val 
                405                 410                 415     


Gln Phe Ser His Ala Met Asp Thr Leu Leu Phe Arg Leu Tyr Leu Leu 
            420                 425                 430         


Phe Met Ala Ser Ser Ile Leu Thr Val Ile Val Leu Trp Asn Thr 
        435                 440                 445         


<210>  5663
<211>  1306
<212>  PRT
<213>  Homo sapiens

<400>  5663

Met Asp Ser Leu Pro Arg Leu Thr Ser Val Leu Thr Leu Leu Phe Ser 
1               5                   10                  15      


Gly Leu Trp His Leu Gly Leu Thr Ala Thr Asn Tyr Asn Cys Asp Asp 
            20                  25                  30          


Pro Leu Ala Ser Leu Leu Ser Pro Met Ala Phe Ser Ser Ser Ser Asp 
        35                  40                  45              


Leu Thr Gly Thr His Ser Pro Ala Gln Leu Asn Trp Arg Val Gly Thr 
    50                  55                  60                  


Gly Gly Trp Ser Pro Ala Asp Ser Asn Ala Gln Gln Trp Leu Gln Met 
65                  70                  75                  80  


Asp Leu Gly Asn Arg Val Glu Ile Thr Ala Val Ala Thr Gln Gly Arg 
                85                  90                  95      


Tyr Gly Ser Ser Asp Trp Val Thr Ser Tyr Ser Leu Met Phe Ser Asp 
            100                 105                 110         


Thr Gly Arg Asn Trp Lys Gln Tyr Lys Gln Glu Asp Ser Ile Trp Thr 
        115                 120                 125             


Phe Ala Gly Asn Met Asn Ala Asp Ser Val Val His His Lys Leu Leu 
    130                 135                 140                 


His Ser Val Arg Ala Arg Phe Val Arg Phe Val Pro Leu Glu Trp Asn 
145                 150                 155                 160 


Pro Ser Gly Lys Ile Gly Met Arg Val Glu Val Tyr Gly Cys Ser Tyr 
                165                 170                 175     


Lys Ser Asp Val Ala Asp Phe Asp Gly Arg Ser Ser Leu Leu Tyr Arg 
            180                 185                 190         


Phe Asn Gln Lys Leu Met Ser Thr Leu Lys Asp Val Ile Ser Leu Lys 
        195                 200                 205             


Phe Lys Ser Met Gln Gly Asp Gly Val Leu Phe His Gly Glu Gly Gln 
    210                 215                 220                 


Arg Gly Asp His Ile Thr Leu Glu Leu Gln Lys Gly Arg Leu Ala Leu 
225                 230                 235                 240 


His Leu Asn Leu Gly Asp Ser Lys Ala Arg Leu Ser Ser Ser Leu Pro 
                245                 250                 255     


Ser Ala Thr Leu Gly Ser Leu Leu Asp Asp Gln His Trp His Ser Val 
            260                 265                 270         


Leu Ile Glu Arg Val Gly Lys Gln Val Asn Phe Thr Val Asp Lys His 
        275                 280                 285             


Thr Gln His Phe Arg Thr Lys Gly Glu Thr Asp Ala Leu Asp Ile Asp 
    290                 295                 300                 


Tyr Glu Leu Ser Phe Gly Gly Ile Pro Val Pro Gly Lys Pro Gly Thr 
305                 310                 315                 320 


Phe Leu Lys Lys Asn Phe His Gly Cys Ile Glu Asn Leu Tyr Tyr Asn 
                325                 330                 335     


Gly Val Asn Ile Ile Asp Leu Ala Lys Arg Arg Lys His Gln Ile Tyr 
            340                 345                 350         


Thr Gly Asn Val Thr Phe Ser Cys Ser Glu Pro Gln Ile Val Pro Ile 
        355                 360                 365             


Thr Phe Val Asn Ser Ser Gly Ser Tyr Leu Leu Leu Pro Gly Thr Pro 
    370                 375                 380                 


Gln Ile Asp Gly Leu Ser Val Ser Phe Gln Phe Arg Thr Trp Asn Lys 
385                 390                 395                 400 


Asp Gly Leu Leu Leu Ser Thr Glu Leu Ser Glu Gly Ser Gly Thr Leu 
                405                 410                 415     


Leu Leu Ser Leu Glu Gly Gly Ile Leu Arg Leu Val Ile Gln Lys Met 
            420                 425                 430         


Thr Glu Arg Val Ala Glu Ile Leu Thr Gly Ser Asn Leu Asn Asp Gly 
        435                 440                 445             


Leu Trp His Ser Val Ser Ile Asn Ala Arg Arg Asn Arg Ile Thr Leu 
    450                 455                 460                 


Thr Leu Asp Asp Glu Ala Ala Pro Pro Ala Pro Asp Ser Thr Trp Val 
465                 470                 475                 480 


Gln Ile Tyr Ser Gly Asn Ser Tyr Tyr Phe Gly Gly Cys Pro Asp Asn 
                485                 490                 495     


Leu Thr Asp Ser Gln Cys Leu Asn Pro Ile Lys Ala Phe Gln Gly Cys 
            500                 505                 510         


Met Arg Leu Ile Phe Ile Asp Asn Gln Pro Lys Asp Leu Ile Ser Val 
        515                 520                 525             


Gln Gln Gly Ser Leu Gly Asn Phe Ser Asp Leu His Ile Asp Leu Cys 
    530                 535                 540                 


Ser Ile Lys Asp Arg Cys Leu Pro Asn Tyr Cys Glu His Gly Gly Ser 
545                 550                 555                 560 


Cys Ser Gln Ser Trp Thr Thr Phe Tyr Cys Asn Cys Ser Asp Thr Ser 
                565                 570                 575     


Tyr Thr Gly Ala Thr Cys His Asn Ser Ile Tyr Glu Gln Ser Cys Glu 
            580                 585                 590         


Val Tyr Arg His Gln Gly Asn Thr Ala Gly Phe Phe Tyr Ile Asp Ser 
        595                 600                 605             


Asp Gly Ser Gly Pro Leu Gly Pro Leu Gln Val Tyr Cys Asn Ile Thr 
    610                 615                 620                 


Glu Asp Lys Ile Trp Thr Ser Val Gln His Asn Asn Thr Glu Leu Thr 
625                 630                 635                 640 


Arg Val Arg Gly Ala Asn Pro Glu Lys Pro Tyr Ala Met Ala Leu Asp 
                645                 650                 655     


Tyr Gly Gly Ser Met Glu Gln Leu Glu Ala Val Ile Asp Gly Ser Glu 
            660                 665                 670         


His Cys Glu Gln Glu Val Ala Tyr His Cys Arg Arg Ser Arg Leu Leu 
        675                 680                 685             


Asn Thr Pro Asp Gly Thr Pro Phe Thr Trp Trp Ile Gly Arg Ser Asn 
    690                 695                 700                 


Glu Arg His Pro Tyr Trp Gly Gly Ser Pro Pro Gly Val Gln Gln Cys 
705                 710                 715                 720 


Glu Cys Gly Leu Asp Glu Ser Cys Leu Asp Ile Gln His Phe Cys Asn 
                725                 730                 735     


Cys Asp Ala Asp Lys Asp Glu Trp Thr Asn Asp Thr Gly Phe Leu Ser 
            740                 745                 750         


Phe Lys Asp His Leu Pro Val Thr Gln Ile Val Ile Thr Asp Thr Asp 
        755                 760                 765             


Arg Ser Asn Ser Glu Ala Ala Trp Arg Ile Gly Pro Leu Arg Cys Tyr 
    770                 775                 780                 


Gly Asp Arg Arg Phe Trp Asn Ala Val Ser Phe Tyr Thr Glu Ala Ser 
785                 790                 795                 800 


Tyr Leu His Phe Pro Thr Phe His Ala Glu Phe Ser Ala Asp Ile Ser 
                805                 810                 815     


Phe Phe Phe Lys Thr Thr Ala Leu Ser Gly Val Phe Leu Glu Asn Leu 
            820                 825                 830         


Gly Ile Lys Asp Phe Ile Arg Leu Glu Ile Ser Ser Pro Ser Glu Ile 
        835                 840                 845             


Thr Phe Ala Ile Asp Val Gly Asn Gly Pro Val Glu Leu Val Val Gln 
    850                 855                 860                 


Ser Pro Ser Leu Leu Asn Asp Asn Gln Trp His Tyr Val Arg Ala Glu 
865                 870                 875                 880 


Arg Asn Leu Lys Glu Thr Ser Leu Gln Val Asp Asn Leu Pro Arg Ser 
                885                 890                 895     


Thr Arg Glu Thr Ser Glu Glu Gly His Phe Arg Leu Gln Leu Asn Ser 
            900                 905                 910         


Gln Leu Phe Val Gly Gly Thr Ser Ser Arg Gln Lys Gly Phe Leu Gly 
        915                 920                 925             


Cys Ile Arg Ser Leu His Leu Asn Gly Gln Lys Met Asp Leu Glu Glu 
    930                 935                 940                 


Arg Ala Lys Val Thr Ser Gly Val Arg Pro Gly Cys Pro Gly His Cys 
945                 950                 955                 960 


Ser Ser Tyr Gly Ser Ile Cys His Asn Gly Gly Lys Cys Val Glu Lys 
                965                 970                 975     


His Asn Gly Tyr Leu Cys Asp Cys Thr Asn Ser Pro Tyr Glu Gly Pro 
            980                 985                 990         


Phe Cys Lys Lys Glu Val Ser Ala  Val Phe Glu Ala Gly  Thr Ser Val 
        995                 1000                 1005             


Thr Tyr  Met Phe Gln Glu Pro  Tyr Pro Val Thr Lys  Asn Ile Ser 
    1010                 1015                 1020             


Leu Ser  Ser Ser Ala Ile Tyr  Thr Asp Ser Ala Pro  Ser Lys Glu 
    1025                 1030                 1035             


Asn Ile  Ala Leu Ser Phe Val  Thr Thr Gln Ala Pro  Ser Leu Leu 
    1040                 1045                 1050             


Leu Phe  Ile Asn Ser Ser Ser  Gln Asp Phe Val Val  Val Leu Leu 
    1055                 1060                 1065             


Cys Lys  Asn Gly Ser Leu Gln  Val Arg Tyr His Leu  Asn Lys Glu 
    1070                 1075                 1080             


Glu Thr  His Val Phe Thr Ile  Asp Ala Asp Asn Phe  Ala Asn Arg 
    1085                 1090                 1095             


Arg Met  His His Leu Lys Ile  Asn Arg Glu Gly Arg  Glu Leu Thr 
    1100                 1105                 1110             


Ile Gln  Met Asp Gln Gln Leu  Arg Leu Ser Tyr Asn  Phe Ser Pro 
    1115                 1120                 1125             


Glu Val  Glu Phe Arg Val Ile  Arg Ser Leu Thr Leu  Gly Lys Val 
    1130                 1135                 1140             


Thr Glu  Asn Leu Gly Leu Asp  Ser Glu Val Ala Lys  Ala Asn Ala 
    1145                 1150                 1155             


Met Gly  Phe Ala Gly Cys Met  Ser Ser Val Gln Tyr  Asn His Ile 
    1160                 1165                 1170             


Ala Pro  Leu Lys Ala Ala Leu  Arg His Ala Thr Val  Ala Pro Val 
    1175                 1180                 1185             


Thr Val  His Gly Thr Leu Thr  Glu Ser Ser Cys Gly  Phe Met Val 
    1190                 1195                 1200             


Asp Ser  Asp Val Asn Ala Val  Thr Thr Val His Ser  Ser Ser Asp 
    1205                 1210                 1215             


Pro Phe  Gly Lys Thr Asp Glu  Arg Glu Pro Leu Thr  Asn Ala Val 
    1220                 1225                 1230             


Arg Ser  Asp Ser Ala Val Ile  Gly Gly Val Ile Ala  Val Val Ile 
    1235                 1240                 1245             


Phe Ile  Ile Phe Cys Ile Ile  Gly Ile Met Thr Arg  Phe Leu Tyr 
    1250                 1255                 1260             


Gln His  Lys Gln Ser His Arg  Thr Ser Gln Met Lys  Glu Lys Glu 
    1265                 1270                 1275             


Tyr Pro  Glu Asn Leu Asp Ser  Ser Phe Arg Asn Glu  Ile Asp Leu 
    1280                 1285                 1290             


Gln Asn  Thr Val Ser Glu Cys  Lys Arg Glu Tyr Phe  Ile 
    1295                 1300                 1305     


<210>  5664
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  5664

Met Glu Gly Asp Cys Leu Ser Cys Met Lys Tyr Leu Met Phe Val Phe 
1               5                   10                  15      


Asn Phe Phe Ile Phe Leu Gly Gly Ala Cys Leu Leu Ala Ile Gly Ile 
            20                  25                  30          


Trp Val Met Val Asp Pro Thr Gly Phe Arg Glu Ile Val Ala Ala Asn 
        35                  40                  45              


Pro Leu Leu Leu Thr Gly Ala Tyr Ile Leu Leu Ala Met Gly Gly Leu 
    50                  55                  60                  


Leu Phe Leu Leu Gly Phe Leu Gly Cys Cys Gly Ala Val Arg Glu Asn 
65                  70                  75                  80  


Lys Cys Leu Leu Leu Phe Phe Phe Leu Phe Ile Leu Ile Ile Phe Leu 
                85                  90                  95      


Ala Glu Leu Ser Ala Ala Ile Leu Ala Phe Ile Phe Arg Glu Asn Leu 
            100                 105                 110         


Thr Arg Glu Phe Phe Thr Lys Glu Leu Thr Lys His Tyr Gln Gly Asn 
        115                 120                 125             


Asn Asp Thr Asp Val Phe Ser Ala Thr Trp Asn Ser Val Met Ile Thr 
    130                 135                 140                 


Phe Gly Cys Cys Gly Val Asn Gly Pro Glu Asp Phe Lys Phe Ala Ser 
145                 150                 155                 160 


Val Phe Arg Leu Leu Thr Leu Asp Ser Glu Glu Val Pro Glu Ala Cys 
                165                 170                 175     


Cys Arg Arg Glu Pro Gln Ser Arg Asp Gly Val Leu Leu Ser Arg Glu 
            180                 185                 190         


Glu Cys Leu Leu Gly Arg Ser Leu Phe Leu Asn Lys Gln Gly Cys Tyr 
        195                 200                 205             


Thr Val Ile Leu Asn Thr Phe Glu Thr Tyr Val Tyr Leu Ala Gly Ala 
    210                 215                 220                 


Leu Ala Ile Gly Val Leu Ala Ile Glu Leu Phe Ala Met Ile Phe Ala 
225                 230                 235                 240 


Met Cys Leu Phe Arg Gly Ile Gln 
                245             


<210>  5665
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  5665

Met Met Ala Glu Pro Trp Gln Ala Leu Gln Leu Leu Leu Ala Ile Leu 
1               5                   10                  15      


Leu Thr Leu Met Ala Leu Pro Tyr Gln Ala Arg Lys Lys Thr Phe Leu 
            20                  25                  30          


Ser Val His Glu Val Met Ala Val Glu Asn Tyr Ala Lys Asp Ser Leu 
        35                  40                  45              


Gln Trp Ile Thr Asp Gln Tyr Asn Lys Glu Ser Asp Asp Lys Tyr His 
    50                  55                  60                  


Phe Arg Ile Phe Arg Val Leu Lys Val Gln Arg Gln Val Thr Asp His 
65                  70                  75                  80  


Leu Glu Tyr His Leu Asn Val Glu Met Gln Trp Thr Thr Cys Gln Lys 
                85                  90                  95      


Pro Glu Thr Thr Asn Cys Val Pro Gln Glu Arg Glu Leu His Lys Gln 
            100                 105                 110         


Val Asn Cys Phe Phe Ser Val Phe Ala Val Pro Trp Phe Glu Gln Tyr 
        115                 120                 125             


Lys Ile Leu Asn Lys Ser Cys Ser Ser Asp 
    130                 135             


<210>  5666
<211>  865
<212>  PRT
<213>  Homo sapiens

<400>  5666

Met Ala Ser Leu Tyr Gln Arg Phe Thr Gly Lys Ile Asn Thr Ser Arg 
1               5                   10                  15      


Ser Phe Pro Ala Pro Pro Glu Ala Ser His Leu Leu Gly Gly Gln Gly 
            20                  25                  30          


Pro Glu Glu Asp Gly Gly Ala Gly Ala Lys Pro Leu Gly Pro Arg Ala 
        35                  40                  45              


Gln Ala Ala Ala Pro Arg Glu Arg Gly Gly Gly Gly Gly Gly Ala Gly 
    50                  55                  60                  


Gly Arg Pro Arg Phe Gln Tyr Gln Ala Arg Ser Asp Gly Asp Glu Glu 
65                  70                  75                  80  


Asp Glu Leu Val Gly Ser Asn Pro Pro Gln Arg Asn Trp Lys Gly Ile 
                85                  90                  95      


Ala Ile Ala Leu Leu Val Ile Leu Val Ile Cys Ser Leu Ile Val Thr 
            100                 105                 110         


Ser Val Ile Leu Leu Thr Pro Ala Glu Asp Asn Ser Leu Ser Gln Lys 
        115                 120                 125             


Lys Lys Val Thr Val Glu Asp Leu Phe Ser Glu Asp Phe Lys Ile His 
    130                 135                 140                 


Asp Pro Glu Ala Lys Trp Ile Ser Asp Thr Glu Phe Ile Tyr Arg Glu 
145                 150                 155                 160 


Gln Lys Gly Thr Val Arg Leu Trp Asn Val Glu Thr Asn Thr Ser Thr 
                165                 170                 175     


Val Leu Ile Glu Gly Lys Lys Ile Glu Ser Leu Arg Ala Ile Arg Tyr 
            180                 185                 190         


Glu Ile Ser Pro Asp Arg Glu Tyr Ala Leu Phe Ser Tyr Asn Val Glu 
        195                 200                 205             


Pro Ile Tyr Gln His Ser Tyr Thr Gly Tyr Tyr Val Leu Ser Lys Ile 
    210                 215                 220                 


Pro His Gly Asp Pro Gln Ser Leu Asp Pro Pro Glu Val Ser Asn Ala 
225                 230                 235                 240 


Lys Leu Gln Tyr Ala Gly Trp Gly Pro Lys Gly Gln Gln Leu Ile Phe 
                245                 250                 255     


Ile Phe Glu Asn Asn Ile Tyr Tyr Cys Ala His Val Gly Lys Gln Ala 
            260                 265                 270         


Ile Arg Val Val Ser Thr Gly Lys Glu Gly Val Ile Tyr Asn Gly Leu 
        275                 280                 285             


Ser Asp Trp Leu Tyr Glu Glu Glu Ile Leu Lys Thr His Ile Ala His 
    290                 295                 300                 


Trp Trp Ser Pro Asp Gly Thr Arg Leu Ala Tyr Ala Ala Ile Asn Asp 
305                 310                 315                 320 


Ser Arg Val Pro Ile Met Glu Leu Pro Thr Tyr Thr Gly Ser Ile Tyr 
                325                 330                 335     


Pro Thr Val Lys Pro Tyr His Tyr Pro Lys Ala Gly Ser Glu Asn Pro 
            340                 345                 350         


Ser Ile Ser Leu His Val Ile Gly Leu Asn Gly Pro Thr His Asp Leu 
        355                 360                 365             


Glu Met Met Pro Pro Asp Asp Pro Arg Met Arg Glu Tyr Tyr Ile Thr 
    370                 375                 380                 


Met Val Lys Trp Ala Thr Ser Thr Lys Val Ala Val Thr Trp Leu Asn 
385                 390                 395                 400 


Arg Ala Gln Asn Val Ser Ile Leu Thr Leu Cys Asp Ala Thr Thr Gly 
                405                 410                 415     


Val Cys Thr Lys Lys His Glu Asp Glu Ser Glu Ala Trp Leu His Arg 
            420                 425                 430         


Gln Asn Glu Glu Pro Val Phe Ser Lys Asp Gly Arg Lys Phe Phe Phe 
        435                 440                 445             


Ile Arg Ala Ile Pro Gln Gly Gly Arg Gly Lys Phe Tyr His Ile Thr 
    450                 455                 460                 


Val Ser Ser Ser Gln Pro Asn Ser Ser Asn Asp Asn Ile Gln Ser Ile 
465                 470                 475                 480 


Thr Ser Gly Asp Trp Asp Val Thr Lys Ile Leu Ala Tyr Asp Glu Lys 
                485                 490                 495     


Gly Asn Lys Ile Tyr Phe Leu Ser Thr Glu Asp Leu Pro Arg Arg Arg 
            500                 505                 510         


Gln Leu Tyr Ser Ala Asn Thr Val Gly Asn Phe Asn Arg Gln Cys Leu 
        515                 520                 525             


Ser Cys Asp Leu Val Glu Asn Cys Thr Tyr Phe Ser Ala Ser Phe Ser 
    530                 535                 540                 


His Ser Met Asp Phe Phe Leu Leu Lys Cys Glu Gly Pro Gly Val Pro 
545                 550                 555                 560 


Met Val Thr Val His Asn Thr Thr Asp Lys Lys Lys Met Phe Asp Leu 
                565                 570                 575     


Glu Thr Asn Glu His Val Lys Lys Ala Ile Asn Asp Arg Gln Met Pro 
            580                 585                 590         


Lys Val Glu Tyr Arg Asp Ile Glu Ile Asp Asp Tyr Asn Leu Pro Met 
        595                 600                 605             


Gln Ile Leu Lys Pro Ala Thr Phe Thr Asp Thr Thr His Tyr Pro Leu 
    610                 615                 620                 


Leu Leu Val Val Asp Gly Thr Pro Gly Ser Gln Ser Val Ala Glu Lys 
625                 630                 635                 640 


Phe Glu Val Ser Trp Glu Thr Val Met Val Ser Ser His Gly Ala Val 
                645                 650                 655     


Val Val Lys Cys Asp Gly Arg Gly Ser Gly Phe Gln Gly Thr Lys Leu 
            660                 665                 670         


Leu His Glu Val Arg Arg Arg Leu Gly Leu Leu Glu Glu Lys Asp Gln 
        675                 680                 685             


Met Glu Ala Val Arg Thr Met Leu Lys Glu Gln Tyr Ile Asp Arg Thr 
    690                 695                 700                 


Arg Val Ala Val Phe Gly Lys Asp Tyr Gly Gly Tyr Leu Ser Thr Tyr 
705                 710                 715                 720 


Ile Leu Pro Ala Lys Gly Glu Asn Gln Gly Gln Thr Phe Thr Cys Gly 
                725                 730                 735     


Ser Ala Leu Ser Pro Ile Thr Asp Phe Lys Leu Tyr Ala Ser Ala Phe 
            740                 745                 750         


Ser Glu Arg Tyr Leu Gly Leu His Gly Leu Asp Asn Arg Ala Tyr Glu 
        755                 760                 765             


Met Thr Lys Val Ala His Arg Val Ser Ala Leu Glu Glu Gln Gln Phe 
    770                 775                 780                 


Leu Ile Ile His Pro Thr Ala Asp Glu Lys Ile His Phe Gln His Thr 
785                 790                 795                 800 


Ala Glu Leu Ile Thr Gln Leu Ile Arg Gly Lys Ala Asn Tyr Ser Leu 
                805                 810                 815     


Gln Ile Tyr Pro Asp Glu Ser His Tyr Phe Thr Ser Ser Ser Leu Lys 
            820                 825                 830         


Gln His Leu Tyr Arg Ser Ile Ile Asn Phe Phe Val Glu Cys Phe Arg 
        835                 840                 845             


Ile Gln Asp Lys Leu Leu Thr Val Thr Ala Lys Glu Asp Glu Glu Glu 
    850                 855                 860                 


Asp 
865 


<210>  5667
<211>  754
<212>  PRT
<213>  Homo sapiens

<400>  5667

Met Ile Val Phe Leu Val Phe Lys His Leu Phe Ser Leu Arg Leu Ile 
1               5                   10                  15      


Thr Met Phe Phe Leu Leu His Phe Ile Val Leu Ile Asn Val Lys Asp 
            20                  25                  30          


Phe Ala Leu Thr Gln Gly Ser Met Ile Thr Pro Ser Cys Gln Lys Gly 
        35                  40                  45              


Tyr Phe Pro Cys Gly Asn Leu Thr Lys Cys Leu Pro Arg Ala Phe His 
    50                  55                  60                  


Cys Asp Gly Lys Asp Asp Cys Gly Asn Gly Ala Asp Glu Glu Asn Cys 
65                  70                  75                  80  


Gly Asp Thr Ser Gly Trp Ala Thr Ile Phe Gly Thr Val His Gly Asn 
                85                  90                  95      


Ala Asn Ser Val Ala Leu Thr Gln Glu Cys Phe Leu Lys Gln Tyr Pro 
            100                 105                 110         


Gln Cys Cys Asp Cys Lys Glu Thr Glu Leu Glu Cys Val Asn Gly Asp 
        115                 120                 125             


Leu Lys Ser Val Pro Met Ile Ser Asn Asn Val Thr Leu Leu Ser Leu 
    130                 135                 140                 


Lys Lys Asn Lys Ile His Ser Leu Pro Asp Lys Val Phe Ile Lys Tyr 
145                 150                 155                 160 


Thr Lys Leu Lys Lys Ile Phe Leu Gln His Asn Cys Ile Arg His Ile 
                165                 170                 175     


Ser Arg Lys Ala Phe Phe Gly Leu Cys Asn Leu Gln Ile Leu Tyr Leu 
            180                 185                 190         


Asn His Asn Cys Ile Thr Thr Leu Arg Pro Gly Ile Phe Lys Asp Leu 
        195                 200                 205             


His Gln Leu Thr Trp Leu Ile Leu Asp Asp Asn Pro Ile Thr Arg Ile 
    210                 215                 220                 


Ser Gln Arg Leu Phe Thr Gly Leu Asn Ser Leu Phe Phe Leu Ser Met 
225                 230                 235                 240 


Val Asn Asn Tyr Leu Glu Ala Leu Pro Lys Gln Met Cys Ala Gln Met 
                245                 250                 255     


Pro Gln Leu Asn Trp Val Asp Leu Glu Gly Asn Arg Ile Lys Tyr Leu 
            260                 265                 270         


Thr Asn Ser Thr Phe Leu Ser Cys Asp Ser Leu Thr Val Leu Phe Leu 
        275                 280                 285             


Pro Arg Asn Gln Ile Gly Phe Val Pro Glu Lys Thr Phe Ser Ser Leu 
    290                 295                 300                 


Lys Asn Leu Gly Glu Leu Asp Leu Ser Ser Asn Thr Ile Thr Glu Leu 
305                 310                 315                 320 


Ser Pro His Leu Phe Lys Asp Leu Lys Leu Leu Gln Lys Leu Asn Leu 
                325                 330                 335     


Ser Ser Asn Pro Leu Met Tyr Leu His Lys Asn Gln Phe Glu Ser Leu 
            340                 345                 350         


Lys Gln Leu Gln Ser Leu Asp Leu Glu Arg Ile Glu Ile Pro Asn Ile 
        355                 360                 365             


Asn Thr Arg Met Phe Gln Pro Met Lys Asn Leu Ser His Ile Tyr Phe 
    370                 375                 380                 


Lys Asn Phe Arg Tyr Cys Ser Tyr Ala Pro His Val Arg Ile Cys Met 
385                 390                 395                 400 


Pro Leu Thr Asp Gly Ile Ser Ser Phe Glu Asp Leu Leu Ala Asn Asn 
                405                 410                 415     


Ile Leu Arg Ile Phe Val Trp Val Ile Ala Phe Ile Thr Cys Phe Gly 
            420                 425                 430         


Asn Leu Phe Val Ile Gly Met Arg Ser Phe Ile Lys Ala Glu Asn Thr 
        435                 440                 445             


Thr His Ala Met Ser Ile Lys Ile Leu Cys Cys Ala Asp Cys Leu Met 
    450                 455                 460                 


Gly Val Tyr Leu Phe Phe Val Gly Ile Phe Asp Ile Lys Tyr Arg Gly 
465                 470                 475                 480 


Gln Tyr Gln Lys Tyr Ala Leu Leu Trp Met Glu Ser Val Gln Cys Arg 
                485                 490                 495     


Leu Met Gly Phe Leu Ala Met Leu Ser Thr Glu Val Ser Val Leu Leu 
            500                 505                 510         


Leu Thr Tyr Leu Thr Leu Glu Lys Phe Leu Val Ile Val Phe Pro Phe 
        515                 520                 525             


Ser Asn Ile Arg Pro Gly Lys Arg Gln Thr Ser Val Ile Leu Ile Cys 
    530                 535                 540                 


Ile Trp Met Ala Gly Phe Leu Ile Ala Val Ile Pro Phe Trp Asn Lys 
545                 550                 555                 560 


Asp Tyr Phe Gly Asn Phe Tyr Gly Lys Asn Gly Val Cys Phe Pro Leu 
                565                 570                 575     


Tyr Tyr Asp Gln Thr Glu Asp Ile Gly Ser Lys Gly Tyr Ser Leu Gly 
            580                 585                 590         


Ile Phe Leu Gly Val Asn Leu Leu Ala Phe Leu Ile Ile Val Phe Ser 
        595                 600                 605             


Tyr Ile Thr Met Phe Cys Ser Ile Gln Lys Thr Ala Leu Gln Thr Thr 
    610                 615                 620                 


Glu Val Arg Asn Cys Phe Gly Arg Glu Val Ala Val Ala Asn Arg Phe 
625                 630                 635                 640 


Phe Phe Ile Val Phe Ser Asp Ala Ile Cys Trp Ile Pro Val Phe Val 
                645                 650                 655     


Val Lys Ile Leu Ser Leu Phe Arg Val Glu Ile Pro Asp Thr Met Thr 
            660                 665                 670         


Ser Trp Ile Val Ile Phe Phe Leu Pro Val Asn Ser Ala Leu Asn Pro 
        675                 680                 685             


Ile Leu Tyr Thr Leu Thr Thr Asn Phe Phe Lys Asp Lys Leu Lys Gln 
    690                 695                 700                 


Leu Leu His Lys His Gln Arg Lys Ser Ile Phe Lys Ile Lys Lys Lys 
705                 710                 715                 720 


Ser Leu Ser Thr Ser Ile Val Trp Ile Glu Asp Ser Ser Ser Leu Lys 
                725                 730                 735     


Leu Gly Val Leu Asn Lys Ile Thr Leu Gly Asp Ser Ile Met Lys Pro 
            740                 745                 750         


Val Ser 
        


<210>  5668
<211>  581
<212>  PRT
<213>  Homo sapiens

<400>  5668

Met Pro Leu Lys His Tyr Leu Leu Leu Leu Val Gly Cys Gln Ala Trp 
1               5                   10                  15      


Gly Ala Gly Leu Ala Tyr His Gly Cys Pro Ser Glu Cys Thr Cys Ser 
            20                  25                  30          


Arg Ala Ser Gln Val Glu Cys Thr Gly Ala Arg Ile Val Ala Val Pro 
        35                  40                  45              


Thr Pro Leu Pro Trp Asn Ala Met Ser Leu Gln Ile Leu Asn Thr His 
    50                  55                  60                  


Ile Thr Glu Leu Asn Glu Ser Pro Phe Leu Asn Ile Ser Ala Leu Ile 
65                  70                  75                  80  


Ala Leu Arg Ile Glu Lys Asn Glu Leu Ser Arg Ile Thr Pro Gly Ala 
                85                  90                  95      


Phe Arg Asn Leu Gly Ser Leu Arg Tyr Leu Ser Leu Ala Asn Asn Lys 
            100                 105                 110         


Leu Gln Val Leu Pro Ile Gly Leu Phe Gln Gly Leu Asp Ser Leu Glu 
        115                 120                 125             


Ser Leu Leu Leu Ser Ser Asn Gln Leu Leu Gln Ile Gln Pro Ala His 
    130                 135                 140                 


Phe Ser Gln Cys Ser Asn Leu Lys Glu Leu Gln Leu His Gly Asn His 
145                 150                 155                 160 


Leu Glu Tyr Ile Pro Asp Gly Ala Phe Asp His Leu Val Gly Leu Thr 
                165                 170                 175     


Lys Leu Asn Leu Gly Lys Asn Ser Leu Thr His Ile Ser Pro Arg Val 
            180                 185                 190         


Phe Gln His Leu Gly Asn Leu Gln Val Leu Arg Leu Tyr Glu Asn Arg 
        195                 200                 205             


Leu Thr Asp Ile Pro Met Gly Thr Phe Asp Gly Leu Val Asn Leu Gln 
    210                 215                 220                 


Glu Leu Ala Leu Gln Gln Asn Gln Ile Gly Leu Leu Ser Pro Gly Leu 
225                 230                 235                 240 


Phe His Asn Asn His Asn Leu Gln Arg Leu Tyr Leu Ser Asn Asn His 
                245                 250                 255     


Ile Ser Gln Leu Pro Pro Ser Val Phe Met Gln Leu Pro Gln Leu Asn 
            260                 265                 270         


Arg Leu Thr Leu Phe Gly Asn Ser Leu Lys Glu Leu Ser Pro Gly Ile 
        275                 280                 285             


Phe Gly Pro Met Pro Asn Leu Arg Glu Leu Trp Leu Tyr Asp Asn His 
    290                 295                 300                 


Ile Ser Ser Leu Pro Asp Asn Val Phe Ser Asn Leu Arg Gln Leu Gln 
305                 310                 315                 320 


Val Leu Ile Leu Ser Arg Asn Gln Ile Ser Phe Ile Ser Pro Gly Ala 
                325                 330                 335     


Phe Asn Gly Leu Thr Glu Leu Arg Glu Leu Ser Leu His Thr Asn Ala 
            340                 345                 350         


Leu Gln Asp Leu Asp Gly Asn Val Phe Arg Met Leu Ala Asn Leu Gln 
        355                 360                 365             


Asn Ile Ser Leu Gln Asn Asn Arg Leu Arg Gln Leu Pro Gly Asn Ile 
    370                 375                 380                 


Phe Ala Asn Val Asn Gly Leu Met Ala Ile Gln Leu Gln Asn Asn Gln 
385                 390                 395                 400 


Leu Glu Asn Leu Pro Leu Gly Ile Phe Asp His Leu Gly Lys Leu Cys 
                405                 410                 415     


Glu Leu Arg Leu Tyr Asp Asn Pro Trp Arg Cys Asp Ser Asp Ile Leu 
            420                 425                 430         


Pro Leu Arg Asn Trp Leu Leu Leu Asn Gln Pro Arg Leu Gly Thr Asp 
        435                 440                 445             


Thr Val Pro Val Cys Phe Ser Pro Ala Asn Val Arg Gly Gln Ser Leu 
    450                 455                 460                 


Ile Ile Ile Asn Val Asn Val Ala Val Pro Ser Val His Val Pro Glu 
465                 470                 475                 480 


Val Pro Ser Tyr Pro Glu Thr Pro Trp Tyr Pro Asp Thr Pro Ser Tyr 
                485                 490                 495     


Pro Asp Thr Thr Ser Val Ser Ser Thr Thr Glu Leu Thr Ser Pro Val 
            500                 505                 510         


Glu Asp Tyr Thr Asp Leu Thr Thr Ile Gln Val Thr Asp Asp Arg Ser 
        515                 520                 525             


Val Trp Gly Met Thr Gln Ala Gln Ser Gly Leu Ala Ile Ala Ala Ile 
    530                 535                 540                 


Val Ile Gly Ile Val Ala Leu Ala Cys Ser Leu Ala Ala Cys Val Gly 
545                 550                 555                 560 


Cys Cys Cys Cys Lys Lys Arg Ser Gln Ala Val Leu Met Gln Met Lys 
                565                 570                 575     


Ala Pro Asn Glu Cys 
            580     


<210>  5669
<211>  840
<212>  PRT
<213>  Homo sapiens

<400>  5669

Met Val Ser Val Phe Arg Ser Glu Glu Met Cys Leu Ser Gln Leu Phe 
1               5                   10                  15      


Leu Gln Val Glu Ala Ala Tyr Cys Cys Val Ala Glu Leu Gly Glu Leu 
            20                  25                  30          


Gly Leu Val Gln Phe Lys Asp Leu Asn Met Asn Val Asn Ser Phe Gln 
        35                  40                  45              


Arg Lys Phe Val Asn Glu Val Arg Arg Cys Glu Ser Leu Glu Arg Ile 
    50                  55                  60                  


Leu Arg Phe Leu Glu Asp Glu Met Gln Asn Glu Ile Val Val Gln Leu 
65                  70                  75                  80  


Leu Glu Lys Ser Pro Leu Thr Pro Leu Pro Arg Glu Met Ile Thr Leu 
                85                  90                  95      


Glu Thr Val Leu Glu Lys Leu Glu Gly Glu Leu Gln Glu Ala Asn Gln 
            100                 105                 110         


Asn Gln Gln Ala Leu Lys Gln Ser Phe Leu Glu Leu Thr Glu Leu Lys 
        115                 120                 125             


Tyr Leu Leu Lys Lys Thr Gln Asp Phe Phe Glu Thr Glu Thr Asn Leu 
    130                 135                 140                 


Ala Asp Asp Phe Phe Thr Glu Asp Thr Ser Gly Leu Leu Glu Leu Lys 
145                 150                 155                 160 


Ala Val Pro Ala Tyr Met Thr Gly Lys Leu Gly Phe Ile Ala Gly Val 
                165                 170                 175     


Ile Asn Arg Glu Arg Met Ala Ser Phe Glu Arg Leu Leu Trp Arg Ile 
            180                 185                 190         


Cys Arg Gly Asn Val Tyr Leu Lys Phe Ser Glu Met Asp Ala Pro Leu 
        195                 200                 205             


Glu Asp Pro Val Thr Lys Glu Glu Ile Gln Lys Asn Ile Phe Ile Ile 
    210                 215                 220                 


Phe Tyr Gln Gly Glu Gln Leu Arg Gln Lys Ile Lys Lys Ile Cys Asp 
225                 230                 235                 240 


Gly Phe Arg Ala Thr Val Tyr Pro Cys Pro Glu Pro Ala Val Glu Arg 
                245                 250                 255     


Arg Glu Met Leu Glu Ser Val Asn Val Arg Leu Glu Asp Leu Ile Thr 
            260                 265                 270         


Val Ile Thr Gln Thr Glu Ser His Arg Gln Arg Leu Leu Gln Glu Ala 
        275                 280                 285             


Ala Ala Asn Trp His Ser Trp Leu Ile Lys Val Gln Lys Met Lys Ala 
    290                 295                 300                 


Val Tyr His Ile Leu Asn Met Cys Asn Ile Asp Val Thr Gln Gln Cys 
305                 310                 315                 320 


Val Ile Ala Glu Ile Trp Phe Pro Val Ala Asp Ala Thr Arg Ile Lys 
                325                 330                 335     


Arg Ala Leu Glu Gln Gly Met Glu Leu Ser Gly Ser Ser Met Ala Pro 
            340                 345                 350         


Ile Met Thr Thr Val Gln Ser Lys Thr Ala Pro Pro Thr Phe Asn Arg 
        355                 360                 365             


Thr Asn Lys Phe Thr Ala Gly Phe Gln Asn Ile Val Asp Ala Tyr Gly 
    370                 375                 380                 


Val Gly Ser Tyr Arg Glu Ile Asn Pro Ala Pro Tyr Thr Ile Ile Thr 
385                 390                 395                 400 


Phe Pro Phe Leu Phe Ala Val Met Phe Gly Asp Cys Gly His Gly Thr 
                405                 410                 415     


Val Met Leu Leu Ala Ala Leu Trp Met Ile Leu Asn Glu Arg Arg Leu 
            420                 425                 430         


Leu Ser Gln Lys Thr Asp Asn Glu Ile Trp Asn Thr Phe Phe His Gly 
        435                 440                 445             


Arg Tyr Leu Ile Leu Leu Met Gly Ile Phe Ser Ile Tyr Thr Gly Leu 
    450                 455                 460                 


Ile Tyr Asn Asp Cys Phe Ser Lys Ser Leu Asn Ile Phe Gly Ser Ser 
465                 470                 475                 480 


Trp Ser Val Gln Pro Met Phe Arg Asn Gly Thr Trp Asn Thr His Val 
                485                 490                 495     


Met Glu Glu Ser Leu Tyr Leu Gln Leu Asp Pro Ala Ile Pro Gly Val 
            500                 505                 510         


Tyr Phe Gly Asn Pro Tyr Pro Phe Gly Ile Asp Pro Ile Trp Asn Leu 
        515                 520                 525             


Ala Ser Asn Lys Leu Thr Phe Leu Asn Ser Tyr Lys Met Lys Met Ser 
    530                 535                 540                 


Val Ile Leu Gly Ile Val Gln Met Val Phe Gly Val Ile Leu Ser Leu 
545                 550                 555                 560 


Phe Asn His Ile Tyr Phe Arg Arg Thr Leu Asn Ile Ile Leu Gln Phe 
                565                 570                 575     


Ile Pro Glu Met Ile Phe Ile Leu Cys Leu Phe Gly Tyr Leu Val Phe 
            580                 585                 590         


Met Ile Ile Phe Lys Trp Cys Cys Phe Asp Val His Val Ser Gln His 
        595                 600                 605             


Ala Pro Ser Ile Leu Ile His Phe Ile Asn Met Phe Leu Phe Asn Tyr 
    610                 615                 620                 


Ser Asp Ser Ser Asn Ala Pro Leu Tyr Lys His Gln Gln Glu Val Gln 
625                 630                 635                 640 


Ser Phe Phe Val Val Met Ala Leu Ile Ser Val Pro Trp Met Leu Leu 
                645                 650                 655     


Ile Lys Pro Phe Ile Leu Arg Ala Ser His Arg Lys Ser Gln Leu Gln 
            660                 665                 670         


Ala Ser Arg Ile Gln Glu Asp Ala Thr Glu Asn Ile Glu Gly Asp Ser 
        675                 680                 685             


Ser Ser Pro Ser Ser Arg Ser Gly Gln Arg Thr Ser Ala Asp Thr His 
    690                 695                 700                 


Gly Ala Leu Asp Asp His Gly Glu Glu Phe Asn Phe Gly Asp Val Phe 
705                 710                 715                 720 


Val His Gln Ala Ile His Thr Ile Glu Tyr Cys Leu Gly Cys Ile Ser 
                725                 730                 735     


Asn Thr Ala Ser Tyr Leu Arg Leu Trp Ala Leu Ser Leu Ala His Ala 
            740                 745                 750         


Gln Leu Ser Glu Val Leu Trp Thr Met Val Met Asn Ser Gly Leu Gln 
        755                 760                 765             


Thr Arg Gly Trp Gly Gly Ile Val Gly Val Phe Ile Ile Phe Ala Val 
    770                 775                 780                 


Phe Ala Val Leu Thr Val Ala Ile Leu Leu Ile Met Glu Gly Leu Ser 
785                 790                 795                 800 


Ala Phe Leu His Ala Leu Arg Leu His Trp Val Glu Phe Gln Asn Lys 
                805                 810                 815     


Phe Tyr Val Gly Asp Gly Tyr Lys Phe Ser Pro Phe Ser Phe Lys His 
            820                 825                 830         


Ile Leu Asp Gly Thr Ala Glu Glu 
        835                 840 


<210>  5670
<211>  840
<212>  PRT
<213>  Homo sapiens

<400>  5670

Met Val Ser Val Phe Arg Ser Glu Glu Met Cys Leu Ser Gln Leu Phe 
1               5                   10                  15      


Leu Gln Val Glu Ala Ala Tyr Cys Cys Val Ala Glu Leu Gly Glu Leu 
            20                  25                  30          


Gly Leu Val Gln Phe Lys Asp Leu Asn Met Asn Val Asn Ser Phe Gln 
        35                  40                  45              


Arg Lys Phe Val Asn Glu Val Arg Arg Cys Glu Ser Leu Glu Arg Ile 
    50                  55                  60                  


Leu Arg Phe Leu Glu Asp Glu Met Gln Asn Glu Ile Val Val Gln Leu 
65                  70                  75                  80  


Leu Glu Lys Ser Pro Leu Thr Pro Leu Pro Arg Glu Met Ile Thr Leu 
                85                  90                  95      


Glu Thr Val Leu Glu Lys Leu Glu Gly Glu Leu Gln Glu Ala Asn Gln 
            100                 105                 110         


Asn Gln Gln Ala Leu Lys Gln Ser Phe Leu Glu Leu Thr Glu Leu Lys 
        115                 120                 125             


Tyr Leu Leu Lys Lys Thr Gln Asp Phe Phe Glu Thr Glu Thr Asn Leu 
    130                 135                 140                 


Ala Asp Asp Phe Phe Thr Glu Asp Thr Ser Gly Leu Leu Glu Leu Lys 
145                 150                 155                 160 


Ala Val Pro Ala Tyr Met Thr Gly Lys Leu Gly Phe Ile Ala Gly Val 
                165                 170                 175     


Ile Asn Arg Glu Arg Met Ala Ser Phe Glu Arg Leu Leu Trp Arg Ile 
            180                 185                 190         


Cys Arg Gly Asn Val Tyr Leu Lys Phe Ser Glu Met Asp Ala Pro Leu 
        195                 200                 205             


Glu Asp Pro Val Thr Lys Glu Glu Ile Gln Lys Asn Ile Phe Ile Ile 
    210                 215                 220                 


Phe Tyr Gln Gly Glu Gln Leu Arg Gln Lys Ile Lys Lys Ile Cys Asp 
225                 230                 235                 240 


Gly Phe Arg Ala Thr Val Tyr Pro Cys Pro Glu Pro Ala Val Glu Arg 
                245                 250                 255     


Arg Glu Met Leu Glu Ser Val Asn Val Arg Leu Glu Asp Leu Ile Thr 
            260                 265                 270         


Val Ile Thr Gln Thr Glu Ser His Arg Gln Arg Leu Leu Gln Glu Ala 
        275                 280                 285             


Ala Ala Asn Trp His Ser Trp Leu Ile Lys Val Gln Lys Met Lys Ala 
    290                 295                 300                 


Val Tyr His Ile Leu Asn Met Cys Asn Ile Asp Val Thr Gln Gln Cys 
305                 310                 315                 320 


Val Ile Ala Glu Ile Trp Phe Pro Val Ala Asp Ala Thr Arg Ile Lys 
                325                 330                 335     


Arg Ala Leu Glu Gln Gly Met Glu Leu Ser Gly Ser Ser Met Ala Pro 
            340                 345                 350         


Ile Met Thr Thr Val Gln Ser Lys Thr Ala Pro Pro Thr Phe Asn Arg 
        355                 360                 365             


Thr Asn Lys Phe Thr Ala Gly Phe Gln Asn Ile Val Asp Ala Tyr Gly 
    370                 375                 380                 


Val Gly Ser Tyr Arg Glu Ile Asn Pro Ala Pro Tyr Thr Ile Ile Thr 
385                 390                 395                 400 


Phe Pro Phe Leu Phe Ala Val Met Phe Gly Asp Cys Gly His Gly Thr 
                405                 410                 415     


Val Met Leu Leu Ala Ala Leu Trp Met Ile Leu Asn Glu Arg Arg Leu 
            420                 425                 430         


Leu Ser Gln Lys Thr Asp Asn Glu Ile Trp Asn Thr Phe Phe His Gly 
        435                 440                 445             


Arg Tyr Leu Ile Leu Leu Met Gly Ile Phe Ser Ile Tyr Thr Gly Leu 
    450                 455                 460                 


Ile Tyr Asn Asp Cys Phe Ser Lys Ser Leu Asn Ile Phe Gly Ser Ser 
465                 470                 475                 480 


Trp Ser Val Gln Pro Met Phe Arg Asn Gly Thr Trp Asn Thr His Val 
                485                 490                 495     


Met Glu Glu Ser Leu Tyr Leu Gln Leu Asp Pro Ala Ile Pro Gly Val 
            500                 505                 510         


Tyr Phe Gly Asn Pro Tyr Pro Phe Gly Ile Asp Pro Ile Trp Asn Leu 
        515                 520                 525             


Ala Ser Asn Lys Leu Thr Phe Leu Asn Ser Tyr Lys Met Lys Met Ser 
    530                 535                 540                 


Val Ile Leu Gly Ile Val Gln Met Val Phe Gly Val Ile Leu Ser Leu 
545                 550                 555                 560 


Phe Asn His Ile Tyr Phe Arg Arg Thr Leu Asn Ile Ile Leu Gln Phe 
                565                 570                 575     


Ile Pro Glu Met Ile Phe Ile Leu Cys Leu Phe Gly Tyr Leu Val Phe 
            580                 585                 590         


Met Ile Ile Phe Lys Trp Cys Cys Phe Asp Val His Val Ser Gln His 
        595                 600                 605             


Ala Pro Ser Ile Leu Ile His Phe Ile Asn Met Phe Leu Phe Asn Tyr 
    610                 615                 620                 


Ser Asp Ser Ser Asn Ala Pro Leu Tyr Lys His Gln Gln Glu Val Gln 
625                 630                 635                 640 


Ser Phe Phe Val Val Met Ala Leu Ile Ser Val Pro Trp Met Leu Leu 
                645                 650                 655     


Ile Lys Pro Phe Ile Leu Arg Ala Ser His Arg Lys Ser Gln Leu Gln 
            660                 665                 670         


Ala Ser Arg Ile Gln Glu Asp Ala Thr Glu Asn Ile Glu Gly Asp Ser 
        675                 680                 685             


Ser Ser Pro Ser Ser Arg Ser Gly Gln Arg Thr Ser Ala Asp Thr His 
    690                 695                 700                 


Gly Ala Leu Asp Asp His Gly Glu Glu Phe Asn Phe Gly Asp Val Phe 
705                 710                 715                 720 


Val His Gln Ala Ile His Thr Ile Glu Tyr Cys Leu Gly Cys Ile Ser 
                725                 730                 735     


Asn Thr Ala Ser Tyr Leu Arg Leu Trp Ala Leu Ser Leu Ala His Ala 
            740                 745                 750         


Gln Leu Ser Glu Val Leu Trp Thr Met Val Met Asn Ser Gly Leu Gln 
        755                 760                 765             


Thr Arg Gly Trp Gly Gly Ile Val Gly Val Phe Ile Ile Phe Ala Val 
    770                 775                 780                 


Phe Ala Val Leu Thr Val Ala Ile Leu Leu Ile Met Glu Gly Leu Ser 
785                 790                 795                 800 


Ala Phe Leu His Ala Leu Arg Leu His Trp Val Glu Phe Gln Asn Lys 
                805                 810                 815     


Phe Tyr Val Gly Asp Gly Tyr Lys Phe Ser Pro Phe Ser Phe Lys His 
            820                 825                 830         


Ile Leu Asp Gly Thr Ala Glu Glu 
        835                 840 


<210>  5671
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  5671

Met Ile Leu Tyr Arg Leu Lys Glu Arg Phe Gln Leu Ser Leu Arg Gln 
1               5                   10                  15      


Asp Lys Glu Lys Asn Gln Glu Ile His Leu Ser Pro Ile Thr Leu Gln 
            20                  25                  30          


Pro Ala Leu Ser Glu Ala Lys Thr Val His Ser Met Val Gln Pro Glu 
        35                  40                  45              


Gln Ala Pro Lys Val Leu Asn Val Val Val Asp Pro Gln Gly Arg Gly 
    50                  55                  60                  


Ala Pro Glu Ile Lys Ala Thr Thr Ala Thr Ser Val Cys Pro Ser Pro 
65                  70                  75                  80  


Phe Lys Met Lys Pro Ile Gly Leu Gln Glu Arg Arg Gly Ser Asn Val 
                85                  90                  95      


Ser Leu Thr Leu Asp Met Ser Ser Leu Gly Asn Ile Glu Pro Phe Val 
            100                 105                 110         


Ser Ile Pro Thr Pro Arg Glu Lys Val Ala Met Glu Tyr Leu Gln Ser 
        115                 120                 125             


Ala Ser Arg Ile Leu Thr Arg Ser Gln Leu Arg Asp Val Val Ala Ser 
    130                 135                 140                 


Ser His Leu Leu Gln Ser Glu Phe Met Glu Ile Pro Met Asn Phe Val 
145                 150                 155                 160 


Asp Pro Lys Glu Ile Asp Ile Pro Arg His Gly Thr Lys Asn Arg Tyr 
                165                 170                 175     


Lys Thr Ile Leu Pro Asn Pro Leu Ser Arg Val Cys Leu Arg Pro Lys 
            180                 185                 190         


Asn Val Thr Asp Ser Leu Ser Thr Tyr Ile Asn Ala Asn Tyr Ile Arg 
        195                 200                 205             


Gly Tyr Ser Gly Lys Glu Lys Ala Phe Ile Ala Thr Gln Gly Pro Met 
    210                 215                 220                 


Ile Asn Thr Val Asp Asp Phe Trp Gln Met Val Trp Gln Glu Asp Ser 
225                 230                 235                 240 


Pro Val Ile Val Met Ile Thr Lys Leu Lys Glu Lys Asn Glu Lys Cys 
                245                 250                 255     


Val Leu Tyr Trp Pro Glu Lys Arg Gly Ile Tyr Gly Lys Val Glu Val 
            260                 265                 270         


Leu Val Ile Ser Val Asn Glu Cys Asp Asn Tyr Thr Ile Arg Asn Leu 
        275                 280                 285             


Val Leu Lys Gln Gly Ser His Thr Gln His Val Lys His Tyr Trp Tyr 
    290                 295                 300                 


Thr Ser Trp Pro Asp His Lys Thr Pro Asp Ser Ala Gln Pro Leu Leu 
305                 310                 315                 320 


Gln Leu Met Leu Asp Val Glu Glu Asp Arg Leu Ala Ser Gln Gly Arg 
                325                 330                 335     


Gly Pro Val Val Val His Cys Ser Ala Gly Ile Gly Arg Thr Gly Cys 
            340                 345                 350         


Phe Ile Ala Thr Ser Ile Gly Cys Gln Gln Leu Lys Glu Glu Gly Val 
        355                 360                 365             


Val Asp Ala Leu Ser Ile Val Cys Gln Leu Arg Met Asp Arg Gly Gly 
    370                 375                 380                 


Met Val Gln Thr Ser Glu Gln Tyr Glu Phe Val His His Ala Leu Cys 
385                 390                 395                 400 


Leu Tyr Glu Ser Arg Leu Ser Ala Glu Thr Val Gln 
                405                 410         


<210>  5672
<211>  647
<212>  PRT
<213>  Homo sapiens

<400>  5672

Met Ala Ser Leu Val Ser Leu Glu Leu Gly Leu Leu Leu Ala Val Leu 
1               5                   10                  15      


Val Val Thr Ala Thr Ala Ser Pro Pro Ala Gly Leu Leu Ser Leu Leu 
            20                  25                  30          


Thr Ser Gly Gln Gly Ala Leu Asp Gln Glu Ala Leu Gly Gly Leu Leu 
        35                  40                  45              


Asn Thr Leu Ala Asp Arg Val His Cys Ala Asn Gly Pro Cys Gly Lys 
    50                  55                  60                  


Cys Leu Ser Val Glu Asp Ala Leu Gly Leu Gly Glu Pro Glu Gly Ser 
65                  70                  75                  80  


Gly Leu Pro Pro Gly Pro Val Leu Glu Ala Arg Tyr Val Ala Arg Leu 
                85                  90                  95      


Ser Ala Ala Ala Val Leu Tyr Leu Ser Asn Pro Glu Gly Thr Cys Glu 
            100                 105                 110         


Asp Ala Arg Ala Gly Leu Trp Ala Ser His Ala Asp His Leu Leu Ala 
        115                 120                 125             


Leu Leu Glu Ser Pro Lys Ala Leu Thr Pro Gly Leu Ser Trp Leu Leu 
    130                 135                 140                 


Gln Arg Met Gln Ala Arg Ala Ala Gly Gln Thr Pro Lys Thr Ala Cys 
145                 150                 155                 160 


Val Asp Ile Pro Gln Leu Leu Glu Glu Ala Val Gly Ala Gly Ala Pro 
                165                 170                 175     


Gly Ser Ala Gly Gly Val Leu Ala Ala Leu Leu Asp His Val Arg Ser 
            180                 185                 190         


Gly Ser Cys Phe His Ala Leu Pro Ser Pro Gln Tyr Phe Val Asp Phe 
        195                 200                 205             


Val Phe Gln Gln His Ser Ser Glu Val Pro Met Thr Leu Ala Glu Leu 
    210                 215                 220                 


Ser Ala Leu Met Gln Arg Leu Gly Val Gly Arg Glu Ala His Ser Asp 
225                 230                 235                 240 


His Ser His Arg His Arg Gly Ala Ser Ser Arg Asp Pro Val Pro Leu 
                245                 250                 255     


Ile Ser Ser Ser Asn Ser Ser Ser Val Trp Asp Thr Val Cys Leu Ser 
            260                 265                 270         


Ala Arg Asp Val Met Ala Ala Tyr Gly Leu Ser Glu Gln Ala Gly Val 
        275                 280                 285             


Thr Pro Glu Ala Trp Ala Gln Leu Ser Pro Ala Leu Leu Gln Gln Gln 
    290                 295                 300                 


Leu Ser Gly Ala Cys Thr Ser Gln Ser Arg Pro Pro Val Gln Asp Gln 
305                 310                 315                 320 


Leu Ser Gln Ser Glu Arg Tyr Leu Tyr Gly Ser Leu Ala Thr Leu Leu 
                325                 330                 335     


Ile Cys Leu Cys Ala Val Phe Gly Leu Leu Leu Leu Thr Cys Thr Gly 
            340                 345                 350         


Cys Arg Gly Val Thr His Tyr Ile Leu Gln Thr Phe Leu Ser Leu Ala 
        355                 360                 365             


Val Gly Ala Leu Thr Gly Asp Ala Val Leu His Leu Thr Pro Lys Val 
    370                 375                 380                 


Leu Gly Leu His Thr His Ser Glu Glu Gly Leu Ser Pro Gln Pro Thr 
385                 390                 395                 400 


Trp Arg Leu Leu Ala Met Leu Ala Gly Leu Tyr Ala Phe Phe Leu Phe 
                405                 410                 415     


Glu Asn Leu Phe Asn Leu Leu Leu Pro Arg Asp Pro Glu Asp Leu Glu 
            420                 425                 430         


Asp Gly Pro Cys Gly His Ser Ser His Ser His Gly Gly His Ser His 
        435                 440                 445             


Gly Val Ser Leu Gln Leu Ala Pro Ser Glu Leu Arg Gln Pro Lys Pro 
    450                 455                 460                 


Pro His Glu Gly Ser Arg Ala Asp Leu Val Ala Glu Glu Ser Pro Glu 
465                 470                 475                 480 


Leu Leu Asn Pro Glu Pro Arg Arg Leu Ser Pro Glu Leu Arg Leu Leu 
                485                 490                 495     


Pro Tyr Met Ile Thr Leu Gly Asp Ala Val His Asn Phe Ala Asp Gly 
            500                 505                 510         


Leu Ala Val Gly Ala Ala Phe Ala Ser Ser Trp Lys Thr Gly Leu Ala 
        515                 520                 525             


Thr Ser Leu Ala Val Phe Cys His Glu Leu Pro His Glu Leu Gly Asp 
    530                 535                 540                 


Phe Ala Ala Leu Leu His Ala Gly Leu Ser Val Arg Gln Ala Leu Leu 
545                 550                 555                 560 


Leu Asn Leu Ala Ser Ala Leu Thr Ala Phe Ala Gly Leu Tyr Val Ala 
                565                 570                 575     


Leu Ala Val Gly Val Ser Glu Glu Ser Glu Ala Trp Ile Leu Ala Val 
            580                 585                 590         


Ala Thr Gly Leu Phe Leu Tyr Val Ala Leu Cys Asp Met Leu Pro Ala 
        595                 600                 605             


Met Leu Lys Val Arg Asp Pro Arg Pro Trp Leu Leu Phe Leu Leu His 
    610                 615                 620                 


Asn Val Gly Leu Leu Gly Gly Trp Thr Val Leu Leu Leu Leu Ser Leu 
625                 630                 635                 640 


Tyr Glu Asp Asp Ile Thr Phe 
                645         


<210>  5673
<211>  1501
<212>  PRT
<213>  Homo sapiens

<400>  5673

Met Ala Pro Thr Trp Gly Pro Gly Met Val Ser Val Val Gly Pro Met 
1               5                   10                  15      


Gly Leu Leu Val Val Leu Leu Val Gly Gly Cys Ala Ala Glu Glu Pro 
            20                  25                  30          


Pro Arg Phe Ile Lys Glu Pro Lys Asp Gln Ile Gly Val Ser Gly Gly 
        35                  40                  45              


Val Ala Ser Phe Val Cys Gln Ala Thr Gly Asp Pro Lys Pro Arg Val 
    50                  55                  60                  


Thr Trp Asn Lys Lys Gly Lys Lys Val Asn Ser Gln Arg Phe Glu Thr 
65                  70                  75                  80  


Ile Glu Phe Asp Glu Ser Ala Gly Ala Val Leu Arg Ile Gln Pro Leu 
                85                  90                  95      


Arg Thr Pro Arg Asp Glu Asn Val Tyr Glu Cys Val Ala Gln Asn Ser 
            100                 105                 110         


Val Gly Glu Ile Thr Val His Ala Lys Leu Thr Val Leu Arg Glu Asp 
        115                 120                 125             


Gln Leu Pro Ser Gly Phe Pro Asn Ile Asp Met Gly Pro Gln Leu Lys 
    130                 135                 140                 


Val Val Glu Arg Thr Arg Thr Ala Thr Met Leu Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Asn Pro Asp Pro Glu Ile Thr Trp Phe Lys Asp Phe Leu Pro Val Asp 
                165                 170                 175     


Pro Ser Ala Ser Asn Gly Arg Ile Lys Gln Leu Arg Ser Gly Ala Leu 
            180                 185                 190         


Gln Ile Glu Ser Ser Glu Glu Thr Asp Gln Gly Lys Tyr Glu Cys Val 
        195                 200                 205             


Ala Thr Asn Ser Ala Gly Val Arg Tyr Ser Ser Pro Ala Asn Leu Tyr 
    210                 215                 220                 


Val Arg Val Arg Arg Val Ala Pro Arg Phe Ser Ile Leu Pro Met Ser 
225                 230                 235                 240 


His Glu Ile Met Pro Gly Gly Asn Val Asn Ile Thr Cys Val Ala Val 
                245                 250                 255     


Gly Ser Pro Met Pro Tyr Val Lys Trp Met Gln Gly Ala Glu Asp Leu 
            260                 265                 270         


Thr Pro Glu Asp Asp Met Pro Val Gly Arg Asn Val Leu Glu Leu Thr 
        275                 280                 285             


Asp Val Lys Asp Ser Ala Asn Tyr Thr Cys Val Ala Met Ser Ser Leu 
    290                 295                 300                 


Gly Val Ile Glu Ala Val Ala Gln Ile Thr Val Lys Ser Leu Pro Lys 
305                 310                 315                 320 


Ala Pro Gly Thr Pro Met Val Thr Glu Asn Thr Ala Thr Ser Ile Thr 
                325                 330                 335     


Ile Thr Trp Asp Ser Gly Asn Pro Asp Pro Val Ser Tyr Tyr Val Ile 
            340                 345                 350         


Glu Tyr Lys Ser Lys Ser Gln Asp Gly Pro Tyr Gln Ile Lys Glu Asp 
        355                 360                 365             


Ile Thr Thr Thr Arg Tyr Ser Ile Gly Gly Leu Ser Pro Asn Ser Glu 
    370                 375                 380                 


Tyr Glu Ile Trp Val Ser Ala Val Asn Ser Ile Gly Gln Gly Pro Pro 
385                 390                 395                 400 


Ser Glu Ser Val Val Thr Arg Thr Gly Glu Gln Ala Pro Ala Ser Ala 
                405                 410                 415     


Pro Arg Asn Val Gln Ala Arg Met Leu Ser Ala Thr Thr Met Ile Val 
            420                 425                 430         


Gln Trp Glu Glu Pro Val Glu Pro Asn Gly Leu Ile Arg Gly Tyr Arg 
        435                 440                 445             


Val Tyr Tyr Thr Met Glu Pro Glu His Pro Val Gly Asn Trp Gln Lys 
    450                 455                 460                 


His Asn Val Asp Asp Ser Leu Leu Thr Thr Val Gly Ser Leu Leu Glu 
465                 470                 475                 480 


Asp Glu Thr Tyr Thr Val Arg Val Leu Ala Phe Thr Ser Val Gly Asp 
                485                 490                 495     


Gly Pro Leu Ser Asp Pro Ile Gln Val Lys Thr Gln Gln Gly Val Pro 
            500                 505                 510         


Gly Gln Pro Met Asn Leu Arg Ala Glu Ala Arg Ser Glu Thr Ser Ile 
        515                 520                 525             


Thr Leu Ser Trp Ser Pro Pro Arg Gln Glu Ser Ile Ile Lys Tyr Glu 
    530                 535                 540                 


Leu Leu Phe Arg Glu Gly Asp His Gly Arg Glu Val Gly Arg Thr Phe 
545                 550                 555                 560 


Asp Pro Thr Thr Ser Tyr Val Val Glu Asp Leu Lys Pro Asn Thr Glu 
                565                 570                 575     


Tyr Ala Phe Arg Leu Ala Ala Arg Ser Pro Gln Gly Leu Gly Ala Phe 
            580                 585                 590         


Thr Pro Val Val Arg Gln Arg Thr Leu Gln Ser Ile Ser Pro Lys Asn 
        595                 600                 605             


Phe Lys Val Lys Met Ile Met Lys Thr Ser Val Leu Leu Ser Trp Glu 
    610                 615                 620                 


Phe Pro Asp Asn Tyr Asn Ser Pro Thr Pro Tyr Lys Ile Gln Tyr Asn 
625                 630                 635                 640 


Gly Leu Thr Leu Asp Val Asp Gly Arg Thr Thr Lys Lys Leu Ile Thr 
                645                 650                 655     


His Leu Lys Pro His Thr Phe Tyr Asn Phe Val Leu Thr Asn Arg Gly 
            660                 665                 670         


Ser Ser Leu Gly Gly Leu Gln Gln Thr Val Thr Ala Trp Thr Ala Phe 
        675                 680                 685             


Asn Leu Leu Asn Gly Lys Pro Ser Val Ala Pro Lys Pro Asp Ala Asp 
    690                 695                 700                 


Gly Phe Ile Met Val Tyr Leu Pro Asp Gly Gln Ser Pro Val Pro Val 
705                 710                 715                 720 


Gln Ser Tyr Phe Ile Val Met Val Pro Leu Arg Lys Ser Arg Gly Gly 
                725                 730                 735     


Gln Phe Leu Thr Pro Leu Gly Ser Pro Glu Asp Met Asp Leu Glu Glu 
            740                 745                 750         


Leu Ile Gln Asp Ile Ser Arg Leu Gln Arg Arg Ser Leu Arg His Ser 
        755                 760                 765             


Arg Gln Leu Glu Val Pro Arg Pro Tyr Ile Ala Ala Arg Phe Ser Val 
    770                 775                 780                 


Leu Pro Pro Thr Phe His Pro Gly Asp Gln Lys Gln Tyr Gly Gly Phe 
785                 790                 795                 800 


Asp Asn Arg Gly Leu Glu Pro Gly His Arg Tyr Val Leu Phe Val Leu 
                805                 810                 815     


Ala Val Leu Gln Lys Ser Glu Pro Thr Phe Ala Ala Ser Pro Phe Ser 
            820                 825                 830         


Asp Pro Phe Gln Leu Asp Asn Pro Asp Pro Gln Pro Ile Val Asp Gly 
        835                 840                 845             


Glu Glu Gly Leu Ile Trp Val Ile Gly Pro Val Leu Ala Val Val Phe 
    850                 855                 860                 


Ile Ile Cys Ile Val Ile Ala Ile Leu Leu Tyr Lys Asn Lys Pro Asp 
865                 870                 875                 880 


Ser Lys Arg Lys Asp Ser Glu Pro Arg Thr Lys Cys Leu Leu Asn Asn 
                885                 890                 895     


Ala Asp Leu Ala Pro His His Pro Lys Asp Pro Val Glu Met Arg Arg 
            900                 905                 910         


Ile Asn Phe Gln Thr Pro Gly Met Leu Ser His Pro Pro Ile Pro Ile 
        915                 920                 925             


Ala Asp Met Ala Glu His Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu 
    930                 935                 940                 


Lys Leu Ser Gln Glu Tyr Glu Ser Ile Asp Pro Gly Gln Gln Phe Thr 
945                 950                 955                 960 


Trp Glu His Ser Asn Leu Glu Val Asn Lys Pro Lys Asn Arg Tyr Ala 
                965                 970                 975     


Asn Val Ile Ala Tyr Asp His Ser Arg Val Ile Leu Gln Pro Ile Glu 
            980                 985                 990         


Gly Ile Met Gly Ser Asp Tyr Ile  Asn Ala Asn Tyr Val  Asp Gly Tyr 
        995                 1000                 1005             


Arg Cys  Gln Asn Ala Tyr Ile  Ala Thr Gln Gly Pro  Leu Pro Glu 
    1010                 1015                 1020             


Thr Phe  Gly Asp Phe Trp Arg  Met Val Trp Glu Gln  Arg Ser Ala 
    1025                 1030                 1035             


Thr Ile  Val Met Met Thr Arg  Leu Glu Glu Lys Ser  Arg Ile Lys 
    1040                 1045                 1050             


Cys Asp  Gln Tyr Trp Pro Asn  Arg Gly Thr Glu Thr  Tyr Gly Phe 
    1055                 1060                 1065             


Ile Gln  Val Thr Leu Leu Asp  Thr Ile Glu Leu Ala  Thr Phe Cys 
    1070                 1075                 1080             


Val Arg  Thr Phe Ser Leu His  Lys Asn Gly Ser Ser  Glu Lys Arg 
    1085                 1090                 1095             


Glu Val  Arg Gln Phe Gln Phe  Thr Ala Trp Pro Asp  His Gly Val 
    1100                 1105                 1110             


Pro Glu  Tyr Pro Thr Pro Phe  Leu Ala Phe Leu Arg  Arg Val Lys 
    1115                 1120                 1125             


Thr Cys  Asn Pro Pro Asp Ala  Gly Pro Ile Val Val  His Cys Ser 
    1130                 1135                 1140             


Ala Gly  Val Gly Arg Thr Gly  Cys Phe Ile Val Ile  Asp Ala Met 
    1145                 1150                 1155             


Leu Glu  Arg Ile Lys Pro Glu  Lys Thr Val Asp Val  Tyr Gly His 
    1160                 1165                 1170             


Val Thr  Leu Met Arg Ser Gln  Arg Asn Tyr Met Val  Gln Thr Glu 
    1175                 1180                 1185             


Asp Gln  Tyr Ser Phe Ile His  Glu Ala Leu Leu Glu  Ala Val Gly 
    1190                 1195                 1200             


Cys Gly  Asn Thr Glu Val Pro  Ala Arg Ser Leu Tyr  Ala Tyr Ile 
    1205                 1210                 1215             


Gln Lys  Leu Ala Gln Val Glu  Pro Gly Glu His Val  Thr Gly Met 
    1220                 1225                 1230             


Glu Leu  Glu Phe Lys Arg Leu  Ala Asn Ser Lys Ala  His Thr Ser 
    1235                 1240                 1245             


Arg Phe  Ile Ser Ala Asn Leu  Pro Cys Asn Lys Phe  Lys Asn Arg 
    1250                 1255                 1260             


Leu Val  Asn Ile Met Pro Tyr  Glu Ser Thr Arg Val  Cys Leu Gln 
    1265                 1270                 1275             


Pro Ile  Arg Gly Val Glu Gly  Ser Asp Tyr Ile Asn  Ala Ser Phe 
    1280                 1285                 1290             


Ile Asp  Gly Tyr Arg Gln Gln  Lys Ala Tyr Ile Ala  Thr Gln Gly 
    1295                 1300                 1305             


Pro Leu  Ala Glu Thr Thr Glu  Asp Phe Trp Arg Met  Leu Trp Glu 
    1310                 1315                 1320             


Asn Asn  Ser Thr Ile Val Val  Met Leu Thr Lys Leu  Arg Glu Met 
    1325                 1330                 1335             


Gly Arg  Glu Lys Cys His Gln  Tyr Trp Pro Ala Glu  Arg Ser Ala 
    1340                 1345                 1350             


Arg Tyr  Gln Tyr Phe Val Val  Asp Pro Met Ala Glu  Tyr Asn Met 
    1355                 1360                 1365             


Pro Gln  Tyr Ile Leu Arg Glu  Phe Lys Val Thr Asp  Ala Arg Asp 
    1370                 1375                 1380             


Gly Gln  Ser Arg Thr Val Arg  Gln Phe Gln Phe Thr  Asp Trp Pro 
    1385                 1390                 1395             


Glu Gln  Gly Val Pro Lys Ser  Gly Glu Gly Phe Ile  Asp Phe Ile 
    1400                 1405                 1410             


Gly Gln  Val His Lys Thr Lys  Glu Gln Phe Gly Gln  Asp Gly Pro 
    1415                 1420                 1425             


Ile Ser  Val His Cys Ser Ala  Gly Val Gly Arg Thr  Gly Val Phe 
    1430                 1435                 1440             


Ile Thr  Leu Ser Ile Val Leu  Glu Arg Met Arg Tyr  Glu Gly Val 
    1445                 1450                 1455             


Val Asp  Ile Phe Gln Thr Val  Lys Met Leu Arg Thr  Gln Arg Pro 
    1460                 1465                 1470             


Ala Met  Val Gln Thr Glu Asp  Glu Tyr Gln Phe Cys  Tyr Gln Ala 
    1475                 1480                 1485             


Ala Leu  Glu Tyr Leu Gly Ser  Phe Asp His Tyr Ala  Thr 
    1490                 1495                 1500     


<210>  5674
<211>  1910
<212>  PRT
<213>  Homo sapiens

<400>  5674

Met Ala Pro Thr Trp Gly Pro Gly Met Val Ser Val Val Gly Pro Met 
1               5                   10                  15      


Gly Leu Leu Val Val Leu Leu Val Gly Gly Cys Ala Ala Glu Glu Pro 
            20                  25                  30          


Pro Arg Phe Ile Lys Glu Pro Lys Asp Gln Ile Gly Val Ser Gly Gly 
        35                  40                  45              


Val Ala Ser Phe Val Cys Gln Ala Thr Gly Asp Pro Lys Pro Arg Val 
    50                  55                  60                  


Thr Trp Asn Lys Lys Gly Lys Lys Val Asn Ser Gln Arg Phe Glu Thr 
65                  70                  75                  80  


Ile Glu Phe Asp Glu Ser Ala Gly Ala Val Leu Arg Ile Gln Pro Leu 
                85                  90                  95      


Arg Thr Pro Arg Asp Glu Asn Val Tyr Glu Cys Val Ala Gln Asn Ser 
            100                 105                 110         


Val Gly Glu Ile Thr Val His Ala Lys Leu Thr Val Leu Arg Glu Asp 
        115                 120                 125             


Gln Leu Pro Ser Gly Phe Pro Asn Ile Asp Met Gly Pro Gln Leu Lys 
    130                 135                 140                 


Val Val Glu Arg Thr Arg Thr Ala Thr Met Leu Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Asn Pro Asp Pro Glu Ile Thr Trp Phe Lys Asp Phe Leu Pro Val Asp 
                165                 170                 175     


Pro Ser Ala Ser Asn Gly Arg Ile Lys Gln Leu Arg Ser Gly Ala Leu 
            180                 185                 190         


Gln Ile Glu Ser Ser Glu Glu Thr Asp Gln Gly Lys Tyr Glu Cys Val 
        195                 200                 205             


Ala Thr Asn Ser Ala Gly Val Arg Tyr Ser Ser Pro Ala Asn Leu Tyr 
    210                 215                 220                 


Val Arg Val Arg Arg Val Ala Pro Arg Phe Ser Ile Leu Pro Met Ser 
225                 230                 235                 240 


His Glu Ile Met Pro Gly Gly Asn Val Asn Ile Thr Cys Val Ala Val 
                245                 250                 255     


Gly Ser Pro Met Pro Tyr Val Lys Trp Met Gln Gly Ala Glu Asp Leu 
            260                 265                 270         


Thr Pro Glu Asp Asp Met Pro Val Gly Arg Asn Val Leu Glu Leu Thr 
        275                 280                 285             


Asp Val Lys Asp Ser Ala Asn Tyr Thr Cys Val Ala Met Ser Ser Leu 
    290                 295                 300                 


Gly Val Ile Glu Ala Val Ala Gln Ile Thr Val Lys Ser Leu Pro Lys 
305                 310                 315                 320 


Ala Pro Gly Thr Pro Met Val Thr Glu Asn Thr Ala Thr Ser Ile Thr 
                325                 330                 335     


Ile Thr Trp Asp Ser Gly Asn Pro Asp Pro Val Ser Tyr Tyr Val Ile 
            340                 345                 350         


Glu Tyr Lys Ser Lys Ser Gln Asp Gly Pro Tyr Gln Ile Lys Glu Asp 
        355                 360                 365             


Ile Thr Thr Thr Arg Tyr Ser Ile Gly Gly Leu Ser Pro Asn Ser Glu 
    370                 375                 380                 


Tyr Glu Ile Trp Val Ser Ala Val Asn Ser Ile Gly Gln Gly Pro Pro 
385                 390                 395                 400 


Ser Glu Ser Val Val Thr Arg Thr Gly Glu Gln Ala Pro Ala Ser Ala 
                405                 410                 415     


Pro Arg Asn Val Gln Ala Arg Met Leu Ser Ala Thr Thr Met Ile Val 
            420                 425                 430         


Gln Trp Glu Glu Pro Val Glu Pro Asn Gly Leu Ile Arg Gly Tyr Arg 
        435                 440                 445             


Val Tyr Tyr Thr Met Glu Pro Glu His Pro Val Gly Asn Trp Gln Lys 
    450                 455                 460                 


His Asn Val Asp Asp Ser Leu Leu Thr Thr Val Gly Ser Leu Leu Glu 
465                 470                 475                 480 


Asp Glu Thr Tyr Thr Val Arg Val Leu Ala Phe Thr Ser Val Gly Asp 
                485                 490                 495     


Gly Pro Leu Ser Asp Pro Ile Gln Val Lys Thr Gln Gln Gly Val Pro 
            500                 505                 510         


Gly Gln Pro Met Asn Leu Arg Ala Glu Ala Arg Ser Glu Thr Ser Ile 
        515                 520                 525             


Thr Leu Ser Trp Ser Pro Pro Arg Gln Glu Ser Ile Ile Lys Tyr Glu 
    530                 535                 540                 


Leu Leu Phe Arg Glu Gly Asp His Gly Arg Glu Val Gly Arg Thr Phe 
545                 550                 555                 560 


Asp Pro Thr Thr Ser Tyr Val Val Glu Asp Leu Lys Pro Asn Thr Glu 
                565                 570                 575     


Tyr Ala Phe Arg Leu Ala Ala Arg Ser Pro Gln Gly Leu Gly Ala Phe 
            580                 585                 590         


Thr Pro Val Val Arg Gln Arg Thr Leu Gln Ser Lys Pro Ser Ala Pro 
        595                 600                 605             


Pro Gln Asp Val Lys Cys Val Ser Val Arg Ser Thr Ala Ile Leu Val 
    610                 615                 620                 


Ser Trp Arg Pro Pro Pro Pro Glu Thr His Asn Gly Ala Leu Val Gly 
625                 630                 635                 640 


Tyr Ser Val Arg Tyr Arg Pro Leu Gly Ser Glu Asp Pro Glu Pro Lys 
                645                 650                 655     


Glu Val Asn Gly Ile Pro Pro Thr Thr Thr Gln Ile Leu Leu Glu Ala 
            660                 665                 670         


Leu Glu Lys Trp Thr Gln Tyr Arg Ile Thr Thr Val Ala His Thr Glu 
        675                 680                 685             


Val Gly Pro Gly Pro Glu Ser Ser Pro Val Val Val Arg Thr Asp Glu 
    690                 695                 700                 


Asp Val Pro Ser Ala Pro Pro Arg Lys Val Glu Ala Glu Ala Leu Asn 
705                 710                 715                 720 


Ala Thr Ala Ile Arg Val Leu Trp Arg Ser Pro Ala Pro Gly Arg Gln 
                725                 730                 735     


His Gly Gln Ile Arg Gly Tyr Gln Val His Tyr Val Arg Met Glu Gly 
            740                 745                 750         


Ala Glu Ala Arg Gly Pro Pro Arg Ile Lys Asp Val Met Leu Ala Asp 
        755                 760                 765             


Ala Gln Glu Met Val Ile Thr Asn Leu Gln Pro Glu Thr Ala Tyr Ser 
    770                 775                 780                 


Ile Thr Val Ala Ala Tyr Thr Met Lys Gly Asp Gly Ala Arg Ser Lys 
785                 790                 795                 800 


Pro Lys Val Val Val Thr Lys Gly Ala Val Leu Gly Arg Pro Thr Leu 
                805                 810                 815     


Ser Val Gln Gln Thr Pro Glu Gly Ser Leu Leu Ala Arg Trp Glu Pro 
            820                 825                 830         


Pro Ala Gly Thr Ala Glu Asp Gln Val Leu Gly Tyr Arg Leu Gln Phe 
        835                 840                 845             


Gly Arg Glu Asp Ser Thr Pro Leu Ala Thr Leu Glu Phe Pro Pro Ser 
    850                 855                 860                 


Glu Asp Arg Tyr Thr Ala Ser Gly Val His Lys Gly Ala Thr Tyr Val 
865                 870                 875                 880 


Phe Arg Leu Ala Ala Arg Ser Arg Gly Gly Leu Gly Glu Glu Ala Ala 
                885                 890                 895     


Glu Val Leu Ser Ile Pro Glu Asp Thr Pro Arg Gly His Pro Gln Ile 
            900                 905                 910         


Leu Glu Ala Ala Gly Asn Ala Ser Ala Gly Thr Val Leu Leu Arg Trp 
        915                 920                 925             


Leu Pro Pro Val Pro Ala Glu Arg Asn Gly Ala Ile Val Lys Tyr Thr 
    930                 935                 940                 


Val Ala Val Arg Glu Ala Gly Ala Leu Gly Pro Ala Arg Glu Thr Glu 
945                 950                 955                 960 


Leu Pro Ala Ala Ala Glu Pro Gly Ala Glu Asn Ala Leu Thr Leu Gln 
                965                 970                 975     


Gly Leu Lys Pro Asp Thr Ala Tyr Asp Leu Gln Val Arg Ala His Thr 
            980                 985                 990         


Arg Arg Gly Pro Gly Pro Phe Ser  Pro Pro Val Arg Tyr  Arg Thr Phe 
        995                 1000                 1005             


Leu Arg  Asp Gln Val Ser Pro  Lys Asn Phe Lys Val  Lys Met Ile 
    1010                 1015                 1020             


Met Lys  Thr Ser Val Leu Leu  Ser Trp Glu Phe Pro  Asp Asn Tyr 
    1025                 1030                 1035             


Asn Ser  Pro Thr Pro Tyr Lys  Ile Gln Tyr Asn Gly  Leu Thr Leu 
    1040                 1045                 1050             


Asp Val  Asp Gly Arg Thr Thr  Lys Lys Leu Ile Thr  His Leu Lys 
    1055                 1060                 1065             


Pro His  Thr Phe Tyr Asn Phe  Val Leu Thr Asn Arg  Gly Ser Ser 
    1070                 1075                 1080             


Leu Gly  Gly Leu Gln Gln Thr  Val Thr Ala Trp Thr  Ala Phe Asn 
    1085                 1090                 1095             


Leu Leu  Asn Gly Lys Pro Ser  Val Ala Pro Lys Pro  Asp Ala Asp 
    1100                 1105                 1110             


Gly Phe  Ile Met Val Tyr Leu  Pro Asp Gly Gln Ser  Pro Val Pro 
    1115                 1120                 1125             


Val Gln  Ser Tyr Phe Ile Val  Met Val Pro Leu Arg  Lys Ser Arg 
    1130                 1135                 1140             


Gly Gly  Gln Phe Leu Thr Pro  Leu Gly Ser Pro Glu  Asp Met Asp 
    1145                 1150                 1155             


Leu Glu  Glu Leu Ile Gln Asp  Ile Ser Arg Leu Gln  Arg Arg Ser 
    1160                 1165                 1170             


Leu Arg  His Ser Arg Gln Leu  Glu Val Pro Arg Pro  Tyr Ile Ala 
    1175                 1180                 1185             


Ala Arg  Phe Ser Val Leu Pro  Pro Thr Phe His Pro  Gly Asp Gln 
    1190                 1195                 1200             


Lys Gln  Tyr Gly Gly Phe Asp  Asn Arg Gly Leu Glu  Pro Gly His 
    1205                 1210                 1215             


Arg Tyr  Val Leu Phe Val Leu  Ala Val Leu Gln Lys  Ser Glu Pro 
    1220                 1225                 1230             


Thr Phe  Ala Ala Ser Pro Phe  Ser Asp Pro Phe Gln  Leu Asp Asn 
    1235                 1240                 1245             


Pro Asp  Pro Gln Pro Ile Val  Asp Gly Glu Glu Gly  Leu Ile Trp 
    1250                 1255                 1260             


Val Ile  Gly Pro Val Leu Ala  Val Val Phe Ile Ile  Cys Ile Val 
    1265                 1270                 1275             


Ile Ala  Ile Leu Leu Tyr Lys  Asn Lys Pro Asp Ser  Lys Arg Lys 
    1280                 1285                 1290             


Asp Ser  Glu Pro Arg Thr Lys  Cys Leu Leu Asn Asn  Ala Asp Leu 
    1295                 1300                 1305             


Ala Pro  His His Pro Lys Asp  Pro Val Glu Met Arg  Arg Ile Asn 
    1310                 1315                 1320             


Phe Gln  Thr Pro Gly Met Leu  Ser His Pro Pro Ile  Pro Ile Ala 
    1325                 1330                 1335             


Asp Met  Ala Glu His Thr Glu  Arg Leu Lys Ala Asn  Asp Ser Leu 
    1340                 1345                 1350             


Lys Leu  Ser Gln Glu Tyr Glu  Ser Ile Asp Pro Gly  Gln Gln Phe 
    1355                 1360                 1365             


Thr Trp  Glu His Ser Asn Leu  Glu Val Asn Lys Pro  Lys Asn Arg 
    1370                 1375                 1380             


Tyr Ala  Asn Val Ile Ala Tyr  Asp His Ser Arg Val  Ile Leu Gln 
    1385                 1390                 1395             


Pro Ile  Glu Gly Ile Met Gly  Ser Asp Tyr Ile Asn  Ala Asn Tyr 
    1400                 1405                 1410             


Val Asp  Gly Tyr Arg Cys Gln  Asn Ala Tyr Ile Ala  Thr Gln Gly 
    1415                 1420                 1425             


Pro Leu  Pro Glu Thr Phe Gly  Asp Phe Trp Arg Met  Val Trp Glu 
    1430                 1435                 1440             


Gln Arg  Ser Ala Thr Ile Val  Met Met Thr Arg Leu  Glu Glu Lys 
    1445                 1450                 1455             


Ser Arg  Ile Lys Cys Asp Gln  Tyr Trp Pro Asn Arg  Gly Thr Glu 
    1460                 1465                 1470             


Thr Tyr  Gly Phe Ile Gln Val  Thr Leu Leu Asp Thr  Ile Glu Leu 
    1475                 1480                 1485             


Ala Thr  Phe Cys Val Arg Thr  Phe Ser Leu His Lys  Asn Gly Ser 
    1490                 1495                 1500             


Ser Glu  Lys Arg Glu Val Arg  Gln Phe Gln Phe Thr  Ala Trp Pro 
    1505                 1510                 1515             


Asp His  Gly Val Pro Glu Tyr  Pro Thr Pro Phe Leu  Ala Phe Leu 
    1520                 1525                 1530             


Arg Arg  Val Lys Thr Cys Asn  Pro Pro Asp Ala Gly  Pro Ile Val 
    1535                 1540                 1545             


Val His  Cys Ser Ala Gly Val  Gly Arg Thr Gly Cys  Phe Ile Val 
    1550                 1555                 1560             


Ile Asp  Ala Met Leu Glu Arg  Ile Lys Pro Glu Lys  Thr Val Asp 
    1565                 1570                 1575             


Val Tyr  Gly His Val Thr Leu  Met Arg Ser Gln Arg  Asn Tyr Met 
    1580                 1585                 1590             


Val Gln  Thr Glu Asp Gln Tyr  Ser Phe Ile His Glu  Ala Leu Leu 
    1595                 1600                 1605             


Glu Ala  Val Gly Cys Gly Asn  Thr Glu Val Pro Ala  Arg Ser Leu 
    1610                 1615                 1620             


Tyr Ala  Tyr Ile Gln Lys Leu  Ala Gln Val Glu Pro  Gly Glu His 
    1625                 1630                 1635             


Val Thr  Gly Met Glu Leu Glu  Phe Lys Arg Leu Ala  Asn Ser Lys 
    1640                 1645                 1650             


Ala His  Thr Ser Arg Phe Ile  Ser Ala Asn Leu Pro  Cys Asn Lys 
    1655                 1660                 1665             


Phe Lys  Asn Arg Leu Val Asn  Ile Met Pro Tyr Glu  Ser Thr Arg 
    1670                 1675                 1680             


Val Cys  Leu Gln Pro Ile Arg  Gly Val Glu Gly Ser  Asp Tyr Ile 
    1685                 1690                 1695             


Asn Ala  Ser Phe Ile Asp Gly  Tyr Arg Gln Gln Lys  Ala Tyr Ile 
    1700                 1705                 1710             


Ala Thr  Gln Gly Pro Leu Ala  Glu Thr Thr Glu Asp  Phe Trp Arg 
    1715                 1720                 1725             


Met Leu  Trp Glu Asn Asn Ser  Thr Ile Val Val Met  Leu Thr Lys 
    1730                 1735                 1740             


Leu Arg  Glu Met Gly Arg Glu  Lys Cys His Gln Tyr  Trp Pro Ala 
    1745                 1750                 1755             


Glu Arg  Ser Ala Arg Tyr Gln  Tyr Phe Val Val Asp  Pro Met Ala 
    1760                 1765                 1770             


Glu Tyr  Asn Met Pro Gln Tyr  Ile Leu Arg Glu Phe  Lys Val Thr 
    1775                 1780                 1785             


Asp Ala  Arg Asp Gly Gln Ser  Arg Thr Val Arg Gln  Phe Gln Phe 
    1790                 1795                 1800             


Thr Asp  Trp Pro Glu Gln Gly  Val Pro Lys Ser Gly  Glu Gly Phe 
    1805                 1810                 1815             


Ile Asp  Phe Ile Gly Gln Val  His Lys Thr Lys Glu  Gln Phe Gly 
    1820                 1825                 1830             


Gln Asp  Gly Pro Ile Ser Val  His Cys Ser Ala Gly  Val Gly Arg 
    1835                 1840                 1845             


Thr Gly  Val Phe Ile Thr Leu  Ser Ile Val Leu Glu  Arg Met Arg 
    1850                 1855                 1860             


Tyr Glu  Gly Val Val Asp Ile  Phe Gln Thr Val Lys  Met Leu Arg 
    1865                 1870                 1875             


Thr Gln  Arg Pro Ala Met Val  Gln Thr Glu Asp Glu  Tyr Gln Phe 
    1880                 1885                 1890             


Cys Tyr  Gln Ala Ala Leu Glu  Tyr Leu Gly Ser Phe  Asp His Tyr 
    1895                 1900                 1905             


Ala Thr  
    1910 


<210>  5675
<211>  1505
<212>  PRT
<213>  Homo sapiens

<400>  5675

Met Ala Pro Thr Trp Gly Pro Gly Met Val Ser Val Val Gly Pro Met 
1               5                   10                  15      


Gly Leu Leu Val Val Leu Leu Val Gly Gly Cys Ala Ala Glu Glu Pro 
            20                  25                  30          


Pro Arg Phe Ile Lys Glu Pro Lys Asp Gln Ile Gly Val Ser Gly Gly 
        35                  40                  45              


Val Ala Ser Phe Val Cys Gln Ala Thr Gly Asp Pro Lys Pro Arg Val 
    50                  55                  60                  


Thr Trp Asn Lys Lys Gly Lys Lys Val Asn Ser Gln Arg Phe Glu Thr 
65                  70                  75                  80  


Ile Glu Phe Asp Glu Ser Ala Gly Ala Val Leu Arg Ile Gln Pro Leu 
                85                  90                  95      


Arg Thr Pro Arg Asp Glu Asn Val Tyr Glu Cys Val Ala Gln Asn Ser 
            100                 105                 110         


Val Gly Glu Ile Thr Val His Ala Lys Leu Thr Val Leu Arg Glu Asp 
        115                 120                 125             


Gln Leu Pro Ser Gly Phe Pro Asn Ile Asp Met Gly Pro Gln Leu Lys 
    130                 135                 140                 


Val Val Glu Arg Thr Arg Thr Ala Thr Met Leu Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Asn Pro Asp Pro Glu Ile Thr Trp Phe Lys Asp Phe Leu Pro Val Asp 
                165                 170                 175     


Pro Ser Ala Ser Asn Gly Arg Ile Lys Gln Leu Arg Ser Gly Ala Leu 
            180                 185                 190         


Gln Ile Glu Ser Ser Glu Glu Thr Asp Gln Gly Lys Tyr Glu Cys Val 
        195                 200                 205             


Ala Thr Asn Ser Ala Gly Val Arg Tyr Ser Ser Pro Ala Asn Leu Tyr 
    210                 215                 220                 


Val Arg Glu Leu Arg Glu Val Arg Arg Val Ala Pro Arg Phe Ser Ile 
225                 230                 235                 240 


Leu Pro Met Ser His Glu Ile Met Pro Gly Gly Asn Val Asn Ile Thr 
                245                 250                 255     


Cys Val Ala Val Gly Ser Pro Met Pro Tyr Val Lys Trp Met Gln Gly 
            260                 265                 270         


Ala Glu Asp Leu Thr Pro Glu Asp Asp Met Pro Val Gly Arg Asn Val 
        275                 280                 285             


Leu Glu Leu Thr Asp Val Lys Asp Ser Ala Asn Tyr Thr Cys Val Ala 
    290                 295                 300                 


Met Ser Ser Leu Gly Val Ile Glu Ala Val Ala Gln Ile Thr Val Lys 
305                 310                 315                 320 


Ser Leu Pro Lys Ala Pro Gly Thr Pro Met Val Thr Glu Asn Thr Ala 
                325                 330                 335     


Thr Ser Ile Thr Ile Thr Trp Asp Ser Gly Asn Pro Asp Pro Val Ser 
            340                 345                 350         


Tyr Tyr Val Ile Glu Tyr Lys Ser Lys Ser Gln Asp Gly Pro Tyr Gln 
        355                 360                 365             


Ile Lys Glu Asp Ile Thr Thr Thr Arg Tyr Ser Ile Gly Gly Leu Ser 
    370                 375                 380                 


Pro Asn Ser Glu Tyr Glu Ile Trp Val Ser Ala Val Asn Ser Ile Gly 
385                 390                 395                 400 


Gln Gly Pro Pro Ser Glu Ser Val Val Thr Arg Thr Gly Glu Gln Ala 
                405                 410                 415     


Pro Ala Ser Ala Pro Arg Asn Val Gln Ala Arg Met Leu Ser Ala Thr 
            420                 425                 430         


Thr Met Ile Val Gln Trp Glu Glu Pro Val Glu Pro Asn Gly Leu Ile 
        435                 440                 445             


Arg Gly Tyr Arg Val Tyr Tyr Thr Met Glu Pro Glu His Pro Val Gly 
    450                 455                 460                 


Asn Trp Gln Lys His Asn Val Asp Asp Ser Leu Leu Thr Thr Val Gly 
465                 470                 475                 480 


Ser Leu Leu Glu Asp Glu Thr Tyr Thr Val Arg Val Leu Ala Phe Thr 
                485                 490                 495     


Ser Val Gly Asp Gly Pro Leu Ser Asp Pro Ile Gln Val Lys Thr Gln 
            500                 505                 510         


Gln Gly Val Pro Gly Gln Pro Met Asn Leu Arg Ala Glu Ala Arg Ser 
        515                 520                 525             


Glu Thr Ser Ile Thr Leu Ser Trp Ser Pro Pro Arg Gln Glu Ser Ile 
    530                 535                 540                 


Ile Lys Tyr Glu Leu Leu Phe Arg Glu Gly Asp His Gly Arg Glu Val 
545                 550                 555                 560 


Gly Arg Thr Phe Asp Pro Thr Thr Ser Tyr Val Val Glu Asp Leu Lys 
                565                 570                 575     


Pro Asn Thr Glu Tyr Ala Phe Arg Leu Ala Ala Arg Ser Pro Gln Gly 
            580                 585                 590         


Leu Gly Ala Phe Thr Pro Val Val Arg Gln Arg Thr Leu Gln Ser Ile 
        595                 600                 605             


Ser Pro Lys Asn Phe Lys Val Lys Met Ile Met Lys Thr Ser Val Leu 
    610                 615                 620                 


Leu Ser Trp Glu Phe Pro Asp Asn Tyr Asn Ser Pro Thr Pro Tyr Lys 
625                 630                 635                 640 


Ile Gln Tyr Asn Gly Leu Thr Leu Asp Val Asp Gly Arg Thr Thr Lys 
                645                 650                 655     


Lys Leu Ile Thr His Leu Lys Pro His Thr Phe Tyr Asn Phe Val Leu 
            660                 665                 670         


Thr Asn Arg Gly Ser Ser Leu Gly Gly Leu Gln Gln Thr Val Thr Ala 
        675                 680                 685             


Trp Thr Ala Phe Asn Leu Leu Asn Gly Lys Pro Ser Val Ala Pro Lys 
    690                 695                 700                 


Pro Asp Ala Asp Gly Phe Ile Met Val Tyr Leu Pro Asp Gly Gln Ser 
705                 710                 715                 720 


Pro Val Pro Val Gln Ser Tyr Phe Ile Val Met Val Pro Leu Arg Lys 
                725                 730                 735     


Ser Arg Gly Gly Gln Phe Leu Thr Pro Leu Gly Ser Pro Glu Asp Met 
            740                 745                 750         


Asp Leu Glu Glu Leu Ile Gln Asp Ile Ser Arg Leu Gln Arg Arg Ser 
        755                 760                 765             


Leu Arg His Ser Arg Gln Leu Glu Val Pro Arg Pro Tyr Ile Ala Ala 
    770                 775                 780                 


Arg Phe Ser Val Leu Pro Pro Thr Phe His Pro Gly Asp Gln Lys Gln 
785                 790                 795                 800 


Tyr Gly Gly Phe Asp Asn Arg Gly Leu Glu Pro Gly His Arg Tyr Val 
                805                 810                 815     


Leu Phe Val Leu Ala Val Leu Gln Lys Ser Glu Pro Thr Phe Ala Ala 
            820                 825                 830         


Ser Pro Phe Ser Asp Pro Phe Gln Leu Asp Asn Pro Asp Pro Gln Pro 
        835                 840                 845             


Ile Val Asp Gly Glu Glu Gly Leu Ile Trp Val Ile Gly Pro Val Leu 
    850                 855                 860                 


Ala Val Val Phe Ile Ile Cys Ile Val Ile Ala Ile Leu Leu Tyr Lys 
865                 870                 875                 880 


Asn Lys Pro Asp Ser Lys Arg Lys Asp Ser Glu Pro Arg Thr Lys Cys 
                885                 890                 895     


Leu Leu Asn Asn Ala Asp Leu Ala Pro His His Pro Lys Asp Pro Val 
            900                 905                 910         


Glu Met Arg Arg Ile Asn Phe Gln Thr Pro Gly Met Leu Ser His Pro 
        915                 920                 925             


Pro Ile Pro Ile Ala Asp Met Ala Glu His Thr Glu Arg Leu Lys Ala 
    930                 935                 940                 


Asn Asp Ser Leu Lys Leu Ser Gln Glu Tyr Glu Ser Ile Asp Pro Gly 
945                 950                 955                 960 


Gln Gln Phe Thr Trp Glu His Ser Asn Leu Glu Val Asn Lys Pro Lys 
                965                 970                 975     


Asn Arg Tyr Ala Asn Val Ile Ala Tyr Asp His Ser Arg Val Ile Leu 
            980                 985                 990         


Gln Pro Ile Glu Gly Ile Met Gly  Ser Asp Tyr Ile Asn  Ala Asn Tyr 
        995                 1000                 1005             


Val Asp  Gly Tyr Arg Cys Gln  Asn Ala Tyr Ile Ala  Thr Gln Gly 
    1010                 1015                 1020             


Pro Leu  Pro Glu Thr Phe Gly  Asp Phe Trp Arg Met  Val Trp Glu 
    1025                 1030                 1035             


Gln Arg  Ser Ala Thr Ile Val  Met Met Thr Arg Leu  Glu Glu Lys 
    1040                 1045                 1050             


Ser Arg  Ile Lys Cys Asp Gln  Tyr Trp Pro Asn Arg  Gly Thr Glu 
    1055                 1060                 1065             


Thr Tyr  Gly Phe Ile Gln Val  Thr Leu Leu Asp Thr  Ile Glu Leu 
    1070                 1075                 1080             


Ala Thr  Phe Cys Val Arg Thr  Phe Ser Leu His Lys  Asn Gly Ser 
    1085                 1090                 1095             


Ser Glu  Lys Arg Glu Val Arg  Gln Phe Gln Phe Thr  Ala Trp Pro 
    1100                 1105                 1110             


Asp His  Gly Val Pro Glu Tyr  Pro Thr Pro Phe Leu  Ala Phe Leu 
    1115                 1120                 1125             


Arg Arg  Val Lys Thr Cys Asn  Pro Pro Asp Ala Gly  Pro Ile Val 
    1130                 1135                 1140             


Val His  Cys Ser Ala Gly Val  Gly Arg Thr Gly Cys  Phe Ile Val 
    1145                 1150                 1155             


Ile Asp  Ala Met Leu Glu Arg  Ile Lys Pro Glu Lys  Thr Val Asp 
    1160                 1165                 1170             


Val Tyr  Gly His Val Thr Leu  Met Arg Ser Gln Arg  Asn Tyr Met 
    1175                 1180                 1185             


Val Gln  Thr Glu Asp Gln Tyr  Ser Phe Ile His Glu  Ala Leu Leu 
    1190                 1195                 1200             


Glu Ala  Val Gly Cys Gly Asn  Thr Glu Val Pro Ala  Arg Ser Leu 
    1205                 1210                 1215             


Tyr Ala  Tyr Ile Gln Lys Leu  Ala Gln Val Glu Pro  Gly Glu His 
    1220                 1225                 1230             


Val Thr  Gly Met Glu Leu Glu  Phe Lys Arg Leu Ala  Asn Ser Lys 
    1235                 1240                 1245             


Ala His  Thr Ser Arg Phe Ile  Ser Ala Asn Leu Pro  Cys Asn Lys 
    1250                 1255                 1260             


Phe Lys  Asn Arg Leu Val Asn  Ile Met Pro Tyr Glu  Ser Thr Arg 
    1265                 1270                 1275             


Val Cys  Leu Gln Pro Ile Arg  Gly Val Glu Gly Ser  Asp Tyr Ile 
    1280                 1285                 1290             


Asn Ala  Ser Phe Ile Asp Gly  Tyr Arg Gln Gln Lys  Ala Tyr Ile 
    1295                 1300                 1305             


Ala Thr  Gln Gly Pro Leu Ala  Glu Thr Thr Glu Asp  Phe Trp Arg 
    1310                 1315                 1320             


Met Leu  Trp Glu Asn Asn Ser  Thr Ile Val Val Met  Leu Thr Lys 
    1325                 1330                 1335             


Leu Arg  Glu Met Gly Arg Glu  Lys Cys His Gln Tyr  Trp Pro Ala 
    1340                 1345                 1350             


Glu Arg  Ser Ala Arg Tyr Gln  Tyr Phe Val Val Asp  Pro Met Ala 
    1355                 1360                 1365             


Glu Tyr  Asn Met Pro Gln Tyr  Ile Leu Arg Glu Phe  Lys Val Thr 
    1370                 1375                 1380             


Asp Ala  Arg Asp Gly Gln Ser  Arg Thr Val Arg Gln  Phe Gln Phe 
    1385                 1390                 1395             


Thr Asp  Trp Pro Glu Gln Gly  Val Pro Lys Ser Gly  Glu Gly Phe 
    1400                 1405                 1410             


Ile Asp  Phe Ile Gly Gln Val  His Lys Thr Lys Glu  Gln Phe Gly 
    1415                 1420                 1425             


Gln Asp  Gly Pro Ile Ser Val  His Cys Ser Ala Gly  Val Gly Arg 
    1430                 1435                 1440             


Thr Gly  Val Phe Ile Thr Leu  Ser Ile Val Leu Glu  Arg Met Arg 
    1445                 1450                 1455             


Tyr Glu  Gly Val Val Asp Ile  Phe Gln Thr Val Lys  Met Leu Arg 
    1460                 1465                 1470             


Thr Gln  Arg Pro Ala Met Val  Gln Thr Glu Asp Glu  Tyr Gln Phe 
    1475                 1480                 1485             


Cys Tyr  Gln Ala Ala Leu Glu  Tyr Leu Gly Ser Phe  Asp His Tyr 
    1490                 1495                 1500             


Ala Thr  
    1505 


<210>  5676
<211>  1460
<212>  PRT
<213>  Homo sapiens

<400>  5676

Met Ala Ser Leu Ala Ala Leu Ala Leu Ser Leu Leu Leu Arg Leu Gln 
1               5                   10                  15      


Leu Pro Pro Leu Pro Gly Ala Arg Ala Gln Ser Ala Ala Gly Gly Cys 
            20                  25                  30          


Ser Phe Asp Glu His Tyr Ser Asn Cys Gly Tyr Ser Val Ala Leu Gly 
        35                  40                  45              


Thr Asn Gly Phe Thr Trp Glu Gln Ile Asn Thr Trp Glu Lys Pro Met 
    50                  55                  60                  


Leu Asp Gln Ala Val Pro Thr Gly Ser Phe Met Met Val Asn Ser Ser 
65                  70                  75                  80  


Gly Arg Ala Ser Gly Gln Lys Ala His Leu Leu Leu Pro Thr Leu Lys 
                85                  90                  95      


Glu Asn Asp Thr His Cys Ile Asp Phe His Tyr Tyr Phe Ser Ser Arg 
            100                 105                 110         


Asp Arg Ser Ser Pro Gly Ala Leu Asn Val Tyr Val Lys Val Asn Gly 
        115                 120                 125             


Gly Pro Gln Gly Asn Pro Val Trp Asn Val Ser Gly Val Val Thr Glu 
    130                 135                 140                 


Gly Trp Val Lys Ala Glu Leu Ala Ile Ser Thr Phe Trp Pro His Phe 
145                 150                 155                 160 


Tyr Gln Val Ile Phe Glu Ser Val Ser Leu Lys Gly His Pro Gly Tyr 
                165                 170                 175     


Ile Ala Val Asp Glu Val Arg Val Leu Ala His Pro Cys Arg Lys Ala 
            180                 185                 190         


Pro His Phe Leu Arg Leu Gln Asn Val Glu Val Asn Val Gly Gln Asn 
        195                 200                 205             


Ala Thr Phe Gln Cys Ile Ala Gly Gly Lys Trp Ser Gln His Asp Lys 
    210                 215                 220                 


Leu Trp Leu Gln Gln Trp Asn Gly Arg Asp Thr Ala Leu Met Val Thr 
225                 230                 235                 240 


Arg Val Val Asn His Arg Arg Phe Ser Ala Thr Val Ser Val Ala Asp 
                245                 250                 255     


Thr Ala Gln Arg Ser Val Ser Lys Tyr Arg Cys Val Ile Arg Ser Asp 
            260                 265                 270         


Gly Gly Ser Gly Val Ser Asn Tyr Ala Glu Leu Ile Val Lys Glu Pro 
        275                 280                 285             


Pro Thr Pro Ile Ala Pro Pro Glu Leu Leu Ala Val Gly Ala Thr Tyr 
    290                 295                 300                 


Leu Trp Ile Lys Pro Asn Ala Asn Ser Ile Ile Gly Asp Gly Pro Ile 
305                 310                 315                 320 


Ile Leu Lys Glu Val Glu Tyr Arg Thr Thr Thr Gly Thr Trp Ala Glu 
                325                 330                 335     


Thr His Ile Val Asp Ser Pro Asn Tyr Lys Leu Trp His Leu Asp Pro 
            340                 345                 350         


Asp Val Glu Tyr Glu Ile Arg Val Leu Leu Thr Arg Pro Gly Glu Gly 
        355                 360                 365             


Gly Thr Gly Pro Pro Gly Pro Pro Leu Thr Thr Arg Thr Lys Cys Ala 
    370                 375                 380                 


Asp Pro Val His Gly Pro Gln Asn Val Glu Ile Val Asp Ile Arg Ala 
385                 390                 395                 400 


Arg Gln Leu Thr Leu Gln Trp Glu Pro Phe Gly Tyr Ala Val Thr Arg 
                405                 410                 415     


Cys His Ser Tyr Asn Leu Thr Val Gln Tyr Gln Tyr Val Phe Asn Gln 
            420                 425                 430         


Gln Gln Tyr Glu Ala Glu Glu Val Ile Gln Thr Ser Ser His Tyr Thr 
        435                 440                 445             


Leu Arg Gly Leu Arg Pro Phe Met Thr Ile Arg Leu Arg Leu Leu Leu 
    450                 455                 460                 


Ser Asn Pro Glu Gly Arg Met Glu Ser Glu Glu Leu Val Val Gln Thr 
465                 470                 475                 480 


Glu Glu Asp Val Pro Gly Ala Val Pro Leu Glu Ser Ile Gln Gly Gly 
                485                 490                 495     


Pro Phe Glu Glu Lys Ile Tyr Ile Gln Trp Lys Pro Pro Asn Glu Thr 
            500                 505                 510         


Asn Gly Val Ile Thr Leu Tyr Glu Ile Asn Tyr Lys Ala Val Gly Ser 
        515                 520                 525             


Leu Asp Pro Ser Ala Asp Leu Ser Ser Gln Arg Gly Lys Val Phe Lys 
    530                 535                 540                 


Leu Arg Asn Glu Thr His His Leu Phe Val Gly Leu Tyr Pro Gly Thr 
545                 550                 555                 560 


Thr Tyr Ser Phe Thr Ile Lys Ala Ser Thr Ala Lys Gly Phe Gly Pro 
                565                 570                 575     


Pro Val Thr Thr Arg Ile Ala Thr Lys Ile Ser Ala Pro Ser Met Pro 
            580                 585                 590         


Glu Tyr Asp Thr Asp Thr Pro Leu Asn Glu Thr Asp Thr Thr Ile Thr 
        595                 600                 605             


Val Met Leu Lys Pro Ala Gln Ser Arg Gly Ala Pro Val Ser Val Tyr 
    610                 615                 620                 


Gln Leu Val Val Lys Glu Glu Arg Leu Gln Lys Ser Arg Arg Ala Ala 
625                 630                 635                 640 


Asp Ile Ile Glu Cys Phe Ser Val Pro Val Ser Tyr Arg Asn Ala Ser 
                645                 650                 655     


Ser Leu Asp Ser Leu His Tyr Phe Ala Ala Glu Leu Lys Pro Ala Asn 
            660                 665                 670         


Leu Pro Val Thr Gln Pro Phe Thr Val Gly Asp Asn Lys Thr Tyr Asn 
        675                 680                 685             


Gly Tyr Trp Asn Pro Pro Leu Ser Pro Leu Lys Ser Tyr Ser Ile Tyr 
    690                 695                 700                 


Phe Gln Ala Leu Ser Lys Ala Asn Gly Glu Thr Lys Ile Asn Cys Val 
705                 710                 715                 720 


Arg Leu Ala Thr Lys Ala Pro Met Gly Ser Ala Gln Val Thr Pro Gly 
                725                 730                 735     


Thr Pro Leu Cys Leu Leu Thr Thr Gly Ala Ser Thr Gln Asn Ser Asn 
            740                 745                 750         


Thr Val Glu Pro Glu Lys Gln Val Asp Asn Thr Val Lys Met Ala Gly 
        755                 760                 765             


Val Ile Ala Gly Leu Leu Met Phe Ile Ile Ile Leu Leu Gly Val Met 
    770                 775                 780                 


Leu Thr Ile Lys Arg Arg Arg Asn Ala Tyr Ser Tyr Ser Tyr Tyr Leu 
785                 790                 795                 800 


Lys Leu Ala Lys Lys Gln Lys Glu Thr Gln Ser Gly Ala Gln Arg Glu 
                805                 810                 815     


Met Gly Pro Val Ala Ser Ala Asp Lys Pro Thr Thr Lys Leu Ser Ala 
            820                 825                 830         


Ser Arg Asn Asp Glu Gly Phe Ser Ser Ser Ser Gln Asp Val Asn Gly 
        835                 840                 845             


Phe Thr Asp Gly Ser Arg Gly Glu Leu Ser Gln Pro Thr Leu Thr Ile 
    850                 855                 860                 


Gln Thr His Pro Tyr Arg Thr Cys Asp Pro Val Glu Met Ser Tyr Pro 
865                 870                 875                 880 


Arg Asp Gln Phe Gln Pro Ala Ile Arg Val Ala Asp Leu Leu Gln His 
                885                 890                 895     


Ile Thr Gln Met Lys Arg Gly Gln Gly Tyr Gly Phe Lys Glu Glu Tyr 
            900                 905                 910         


Glu Ala Leu Pro Glu Gly Gln Thr Ala Ser Trp Asp Thr Ala Lys Glu 
        915                 920                 925             


Asp Glu Asn Arg Asn Lys Asn Arg Tyr Gly Asn Ile Ile Ser Tyr Asp 
    930                 935                 940                 


His Ser Arg Val Arg Leu Leu Val Leu Asp Gly Asp Pro His Ser Asp 
945                 950                 955                 960 


Tyr Ile Asn Ala Asn Tyr Ile Asp Gly Tyr His Arg Pro Arg His Tyr 
                965                 970                 975     


Ile Ala Thr Gln Gly Pro Met Gln Glu Thr Val Lys Asp Phe Trp Arg 
            980                 985                 990         


Met Ile Trp Gln Glu Asn Ser Ala  Ser Ile Val Met Val  Thr Asn Leu 
        995                 1000                 1005             


Val Glu  Val Gly Arg Val Lys  Cys Val Arg Tyr Trp  Pro Asp Asp 
    1010                 1015                 1020             


Thr Glu  Val Tyr Gly Asp Ile  Lys Val Thr Leu Ile  Glu Thr Glu 
    1025                 1030                 1035             


Pro Leu  Ala Glu Tyr Val Ile  Arg Thr Phe Thr Val  Gln Lys Lys 
    1040                 1045                 1050             


Gly Tyr  His Glu Ile Arg Glu  Leu Arg Leu Phe His  Phe Thr Ser 
    1055                 1060                 1065             


Trp Pro  Asp His Gly Val Pro  Cys Tyr Ala Thr Gly  Leu Leu Gly 
    1070                 1075                 1080             


Phe Val  Arg Gln Val Lys Phe  Leu Asn Pro Pro Glu  Ala Gly Pro 
    1085                 1090                 1095             


Ile Val  Val His Cys Ser Ala  Gly Ala Gly Arg Thr  Gly Cys Phe 
    1100                 1105                 1110             


Ile Ala  Ile Asp Thr Met Leu  Asp Met Ala Glu Asn  Glu Gly Val 
    1115                 1120                 1125             


Val Asp  Ile Phe Asn Cys Val  Arg Glu Leu Arg Ala  Gln Arg Val 
    1130                 1135                 1140             


Asn Leu  Val Gln Thr Glu Glu  Gln Tyr Val Phe Val  His Asp Ala 
    1145                 1150                 1155             


Ile Leu  Glu Ala Cys Leu Cys  Gly Asn Thr Ala Ile  Pro Val Cys 
    1160                 1165                 1170             


Glu Phe  Arg Ser Leu Tyr Tyr  Asn Ile Ser Arg Leu  Asp Pro Gln 
    1175                 1180                 1185             


Thr Asn  Ser Ser Gln Ile Lys  Asp Glu Phe Gln Thr  Leu Asn Ile 
    1190                 1195                 1200             


Val Thr  Pro Arg Val Arg Pro  Glu Asp Cys Ser Ile  Gly Leu Leu 
    1205                 1210                 1215             


Pro Arg  Asn His Asp Lys Asn  Arg Ser Met Asp Val  Leu Pro Leu 
    1220                 1225                 1230             


Asp Arg  Cys Leu Pro Phe Leu  Ile Ser Val Asp Gly  Glu Ser Ser 
    1235                 1240                 1245             


Asn Tyr  Ile Asn Ala Ala Leu  Met Asp Ser His Lys  Gln Pro Ala 
    1250                 1255                 1260             


Ala Phe  Val Val Thr Gln His  Pro Leu Pro Asn Thr  Val Ala Asp 
    1265                 1270                 1275             


Phe Trp  Arg Leu Val Phe Asp  Tyr Asn Cys Ser Ser  Val Val Met 
    1280                 1285                 1290             


Leu Asn  Glu Met Asp Thr Ala  Gln Phe Cys Met Gln  Tyr Trp Pro 
    1295                 1300                 1305             


Glu Lys  Thr Ser Gly Cys Tyr  Gly Pro Ile Gln Val  Glu Phe Val 
    1310                 1315                 1320             


Ser Ala  Asp Ile Asp Glu Asp  Ile Ile His Arg Ile  Phe Arg Ile 
    1325                 1330                 1335             


Cys Asn  Met Ala Arg Pro Gln  Asp Gly Tyr Arg Ile  Val Gln His 
    1340                 1345                 1350             


Leu Gln  Tyr Ile Gly Trp Pro  Ala Tyr Arg Asp Thr  Pro Pro Ser 
    1355                 1360                 1365             


Lys Arg  Ser Leu Leu Lys Val  Val Arg Arg Leu Glu  Lys Trp Gln 
    1370                 1375                 1380             


Glu Gln  Tyr Asp Gly Arg Glu  Gly Arg Thr Val Val  His Cys Leu 
    1385                 1390                 1395             


Asn Gly  Gly Gly Arg Ser Gly  Thr Phe Cys Ala Ile  Cys Ser Val 
    1400                 1405                 1410             


Cys Glu  Met Ile Gln Gln Gln  Asn Ile Ile Asp Val  Phe His Ile 
    1415                 1420                 1425             


Val Lys  Thr Leu Arg Asn Asn  Lys Ser Asn Met Val  Glu Thr Leu 
    1430                 1435                 1440             


Glu Gln  Tyr Lys Phe Val Tyr  Glu Val Ala Leu Glu  Tyr Leu Ser 
    1445                 1450                 1455             


Ser Phe  
    1460 


<210>  5677
<211>  1440
<212>  PRT
<213>  Homo sapiens

<400>  5677

Met Ala Arg Ala Gln Ala Leu Val Leu Ala Leu Thr Phe Gln Leu Cys 
1               5                   10                  15      


Ala Pro Glu Thr Glu Thr Pro Ala Ala Gly Cys Thr Phe Glu Glu Ala 
            20                  25                  30          


Ser Asp Pro Ala Val Pro Cys Glu Tyr Ser Gln Ala Gln Tyr Asp Asp 
        35                  40                  45              


Phe Gln Trp Glu Gln Val Arg Ile His Pro Gly Thr Arg Ala Pro Ala 
    50                  55                  60                  


Asp Leu Pro His Gly Ser Tyr Leu Met Val Asn Thr Ser Gln His Ala 
65                  70                  75                  80  


Pro Gly Gln Arg Ala His Val Ile Phe Gln Ser Leu Ser Glu Asn Asp 
                85                  90                  95      


Thr His Cys Val Gln Phe Ser Tyr Phe Leu Tyr Ser Arg Asp Gly His 
            100                 105                 110         


Ser Pro Gly Thr Leu Gly Val Tyr Val Arg Val Asn Gly Gly Pro Leu 
        115                 120                 125             


Gly Ser Ala Val Trp Asn Met Thr Gly Ser His Gly Arg Gln Trp His 
    130                 135                 140                 


Gln Ala Glu Leu Ala Val Ser Thr Phe Trp Pro Asn Glu Tyr Gln Val 
145                 150                 155                 160 


Leu Phe Glu Ala Leu Ile Ser Pro Asp Arg Arg Gly Tyr Met Gly Leu 
                165                 170                 175     


Asp Asp Ile Leu Leu Leu Ser Tyr Pro Cys Ala Lys Ala Pro His Phe 
            180                 185                 190         


Ser Arg Leu Gly Asp Val Glu Val Asn Ala Gly Gln Asn Ala Ser Phe 
        195                 200                 205             


Gln Cys Met Ala Ala Gly Arg Ala Ala Glu Ala Glu Arg Phe Leu Leu 
    210                 215                 220                 


Gln Arg Gln Ser Gly Ala Leu Val Pro Ala Ala Gly Val Arg His Ile 
225                 230                 235                 240 


Ser His Arg Arg Phe Leu Ala Thr Phe Pro Leu Ala Ala Val Ser Arg 
                245                 250                 255     


Ala Glu Gln Asp Leu Tyr Arg Cys Val Ser Gln Ala Pro Arg Gly Ala 
            260                 265                 270         


Gly Val Ser Asn Phe Ala Glu Leu Ile Val Lys Glu Pro Pro Thr Pro 
        275                 280                 285             


Ile Ala Pro Pro Gln Leu Leu Arg Ala Gly Pro Thr Tyr Leu Ile Ile 
    290                 295                 300                 


Gln Leu Asn Thr Asn Ser Ile Ile Gly Asp Gly Pro Ile Val Arg Lys 
305                 310                 315                 320 


Glu Ile Glu Tyr Arg Met Ala Arg Gly Pro Trp Ala Glu Val His Ala 
                325                 330                 335     


Val Ser Leu Gln Thr Tyr Lys Leu Trp His Leu Asp Pro Asp Thr Glu 
            340                 345                 350         


Tyr Glu Ile Ser Val Leu Leu Thr Arg Pro Gly Asp Gly Gly Thr Gly 
        355                 360                 365             


Arg Pro Gly Pro Pro Leu Ile Ser Arg Thr Lys Cys Ala Glu Pro Met 
    370                 375                 380                 


Arg Ala Pro Lys Gly Leu Ala Phe Ala Glu Ile Gln Ala Arg Gln Leu 
385                 390                 395                 400 


Thr Leu Gln Trp Glu Pro Leu Gly Tyr Asn Val Thr Arg Cys His Thr 
                405                 410                 415     


Tyr Thr Val Ser Leu Cys Tyr His Tyr Thr Leu Gly Ser Ser His Asn 
            420                 425                 430         


Gln Thr Ile Arg Glu Cys Val Lys Thr Glu Gln Gly Val Ser Arg Tyr 
        435                 440                 445             


Thr Ile Lys Asn Leu Leu Pro Tyr Arg Asn Val His Val Arg Leu Val 
    450                 455                 460                 


Leu Thr Asn Pro Glu Gly Arg Lys Glu Gly Lys Glu Val Thr Phe Gln 
465                 470                 475                 480 


Thr Asp Glu Asp Val Pro Ser Gly Ile Ala Ala Glu Ser Leu Thr Phe 
                485                 490                 495     


Thr Pro Leu Glu Asp Met Ile Phe Leu Lys Trp Glu Glu Pro Gln Glu 
            500                 505                 510         


Pro Asn Gly Leu Ile Thr Gln Tyr Glu Ile Ser Tyr Gln Ser Ile Glu 
        515                 520                 525             


Ser Ser Asp Pro Ala Val Asn Val Pro Gly Pro Arg Arg Thr Ile Ser 
    530                 535                 540                 


Lys Leu Arg Asn Glu Thr Tyr His Val Phe Ser Asn Leu His Pro Gly 
545                 550                 555                 560 


Thr Thr Tyr Leu Phe Ser Val Arg Ala Arg Thr Gly Lys Gly Phe Gly 
                565                 570                 575     


Gln Ala Ala Leu Thr Glu Ile Thr Thr Asn Ile Ser Ala Pro Ser Phe 
            580                 585                 590         


Asp Tyr Ala Asp Met Pro Ser Pro Leu Gly Glu Ser Glu Asn Thr Ile 
        595                 600                 605             


Thr Val Leu Leu Arg Pro Ala Gln Gly Arg Gly Ala Pro Ile Ser Val 
    610                 615                 620                 


Tyr Gln Val Ile Val Glu Glu Glu Arg Ala Arg Arg Leu Arg Arg Glu 
625                 630                 635                 640 


Pro Gly Gly Gln Asp Cys Phe Pro Val Pro Leu Thr Phe Glu Ala Ala 
                645                 650                 655     


Leu Ala Arg Gly Leu Val His Tyr Phe Gly Ala Glu Leu Ala Ala Ser 
            660                 665                 670         


Ser Leu Pro Glu Ala Met Pro Phe Thr Val Gly Asp Asn Gln Thr Tyr 
        675                 680                 685             


Arg Gly Phe Trp Asn Pro Pro Leu Glu Pro Arg Lys Ala Tyr Leu Ile 
    690                 695                 700                 


Tyr Phe Gln Ala Ala Ser His Leu Lys Gly Glu Thr Arg Leu Asn Cys 
705                 710                 715                 720 


Ile Arg Ile Ala Arg Lys Ala Ala Cys Lys Glu Ser Lys Arg Pro Leu 
                725                 730                 735     


Glu Val Ser Gln Arg Ser Glu Glu Met Gly Leu Ile Leu Gly Ile Cys 
            740                 745                 750         


Ala Gly Gly Leu Ala Val Leu Ile Leu Leu Leu Gly Ala Ile Ile Val 
        755                 760                 765             


Ile Ile Arg Lys Gly Lys Pro Val Asn Met Thr Lys Ala Thr Val Asn 
    770                 775                 780                 


Tyr Arg Gln Glu Lys Thr His Met Met Ser Ala Val Asp Arg Ser Phe 
785                 790                 795                 800 


Thr Asp Gln Ser Thr Leu Gln Glu Asp Glu Arg Leu Gly Leu Ser Phe 
                805                 810                 815     


Met Asp Thr His Gly Tyr Ser Thr Arg Gly Asp Gln Arg Ser Gly Gly 
            820                 825                 830         


Val Thr Glu Ala Ser Ser Leu Leu Gly Gly Ser Pro Arg Arg Pro Cys 
        835                 840                 845             


Gly Arg Lys Gly Ser Pro Tyr His Thr Gly Gln Leu His Pro Ala Val 
    850                 855                 860                 


Arg Val Ala Asp Leu Leu Gln His Ile Asn Gln Met Lys Thr Ala Glu 
865                 870                 875                 880 


Gly Tyr Gly Phe Lys Gln Glu Tyr Glu Ser Phe Phe Glu Gly Trp Asp 
                885                 890                 895     


Ala Thr Lys Lys Lys Asp Lys Val Lys Gly Ser Arg Gln Glu Pro Met 
            900                 905                 910         


Pro Ala Tyr Asp Arg His Arg Val Lys Leu His Pro Met Leu Gly Asp 
        915                 920                 925             


Pro Asn Ala Asp Tyr Ile Asn Ala Asn Tyr Ile Asp Ile Arg Ile Asn 
    930                 935                 940                 


Arg Glu Gly Tyr His Arg Ser Asn His Phe Ile Ala Thr Gln Gly Pro 
945                 950                 955                 960 


Lys Pro Glu Met Val Tyr Asp Phe Trp Arg Met Val Trp Gln Glu His 
                965                 970                 975     


Cys Ser Ser Ile Val Met Ile Thr Lys Leu Val Glu Val Gly Arg Val 
            980                 985                 990         


Lys Cys Ser Arg Tyr Trp Pro Glu  Asp Ser Asp Thr Tyr  Gly Asp Ile 
        995                 1000                 1005             


Lys Ile  Met Leu Val Lys Thr  Glu Thr Leu Ala Glu  Tyr Val Val 
    1010                 1015                 1020             


Arg Thr  Phe Ala Leu Glu Arg  Arg Gly Tyr Ser Ala  Arg His Glu 
    1025                 1030                 1035             


Val Arg  Gln Phe His Phe Thr  Ala Trp Pro Glu His  Gly Val Pro 
    1040                 1045                 1050             


Tyr His  Ala Thr Gly Leu Leu  Ala Phe Ile Arg Arg  Val Lys Ala 
    1055                 1060                 1065             


Ser Thr  Pro Pro Asp Ala Gly  Pro Ile Val Ile His  Cys Ser Ala 
    1070                 1075                 1080             


Gly Thr  Gly Arg Thr Gly Cys  Tyr Ile Val Leu Asp  Val Met Leu 
    1085                 1090                 1095             


Asp Met  Ala Glu Cys Glu Gly  Val Val Asp Ile Tyr  Asn Cys Val 
    1100                 1105                 1110             


Lys Thr  Leu Cys Ser Arg Arg  Val Asn Met Ile Gln  Thr Glu Glu 
    1115                 1120                 1125             


Gln Tyr  Ile Phe Ile His Asp  Ala Ile Leu Glu Ala  Cys Leu Cys 
    1130                 1135                 1140             


Gly Glu  Thr Thr Ile Pro Val  Ser Glu Phe Lys Ala  Thr Tyr Lys 
    1145                 1150                 1155             


Glu Met  Ile Arg Ile Asp Pro  Gln Ser Asn Ser Ser  Gln Leu Arg 
    1160                 1165                 1170             


Glu Glu  Phe Gln Thr Leu Asn  Ser Val Thr Pro Pro  Leu Asp Val 
    1175                 1180                 1185             


Glu Glu  Cys Ser Ile Ala Leu  Leu Pro Arg Asn Arg  Asp Lys Asn 
    1190                 1195                 1200             


Arg Ser  Met Asp Val Leu Pro  Pro Asp Arg Cys Leu  Pro Phe Leu 
    1205                 1210                 1215             


Ile Ser  Thr Asp Gly Asp Ser  Asn Asn Tyr Ile Asn  Ala Ala Leu 
    1220                 1225                 1230             


Thr Asp  Ser Tyr Thr Arg Ser  Ala Ala Phe Ile Val  Thr Leu His 
    1235                 1240                 1245             


Pro Leu  Gln Ser Thr Thr Pro  Asp Phe Trp Arg Leu  Val Tyr Asp 
    1250                 1255                 1260             


Tyr Gly  Cys Thr Ser Ile Val  Met Leu Asn Gln Leu  Asn Gln Ser 
    1265                 1270                 1275             


Asn Ser  Ala Trp Pro Cys Leu  Gln Tyr Trp Pro Glu  Pro Gly Arg 
    1280                 1285                 1290             


Gln Gln  Tyr Gly Leu Met Glu  Val Glu Phe Met Ser  Gly Thr Ala 
    1295                 1300                 1305             


Asp Glu  Asp Leu Val Ala Arg  Val Phe Arg Val Gln  Asn Ile Ser 
    1310                 1315                 1320             


Arg Glu  Gly His Leu Leu Val  Arg His Phe Gln Phe  Leu Arg Trp 
    1325                 1330                 1335             


Ser Ala  Tyr Arg Asp Thr Pro  Asp Ser Lys Lys Ala  Phe Leu His 
    1340                 1345                 1350             


Leu Leu  Ala Glu Val Asp Lys  Trp Gln Ala Glu Ser  Gly Asp Gly 
    1355                 1360                 1365             


Arg Thr  Ile Val His Cys Leu  Asn Gly Gly Gly Arg  Ser Gly Thr 
    1370                 1375                 1380             


Phe Cys  Ala Cys Ala Thr Val  Leu Glu Met Ile Arg  Cys His Asn 
    1385                 1390                 1395             


Leu Val  Asp Val Phe Phe Ala  Ala Lys Thr Leu Arg  Asn Tyr Lys 
    1400                 1405                 1410             


Pro Asn  Met Val Glu Thr Met  Asp Gln Tyr His Phe  Cys Tyr Asp 
    1415                 1420                 1425             


Val Ala  Leu Glu Tyr Leu Glu  Gly Leu Glu Ser Arg  
    1430                 1435                 1440 


<210>  5678
<211>  1436
<212>  PRT
<213>  Homo sapiens

<400>  5678

Met Ala Arg Ala Gln Ala Leu Val Leu Ala Leu Thr Phe Gln Leu Cys 
1               5                   10                  15      


Ala Pro Glu Thr Glu Thr Pro Ala Ala Gly Cys Thr Phe Glu Glu Ala 
            20                  25                  30          


Ser Asp Pro Ala Val Pro Cys Glu Tyr Ser Gln Ala Gln Tyr Asp Asp 
        35                  40                  45              


Phe Gln Trp Glu Gln Val Arg Ile His Pro Gly Thr Arg Ala Pro Ala 
    50                  55                  60                  


Asp Leu Pro His Gly Ser Tyr Leu Met Val Asn Thr Ser Gln His Ala 
65                  70                  75                  80  


Pro Gly Gln Arg Ala His Val Ile Phe Gln Ser Leu Ser Glu Asn Asp 
                85                  90                  95      


Thr His Cys Val Gln Phe Ser Tyr Phe Leu Tyr Ser Arg Asp Gly His 
            100                 105                 110         


Ser Pro Gly Thr Leu Gly Val Tyr Val Arg Val Asn Gly Gly Pro Leu 
        115                 120                 125             


Gly Ser Ala Val Trp Asn Met Thr Gly Ser His Gly Arg Gln Trp His 
    130                 135                 140                 


Gln Ala Glu Leu Ala Val Ser Thr Phe Trp Pro Asn Glu Tyr Gln Val 
145                 150                 155                 160 


Leu Phe Glu Ala Leu Ile Ser Pro Asp Arg Arg Gly Tyr Met Gly Leu 
                165                 170                 175     


Asp Asp Ile Leu Leu Leu Ser Tyr Pro Cys Ala Lys Ala Pro His Phe 
            180                 185                 190         


Ser Arg Leu Gly Asp Val Glu Val Asn Ala Gly Gln Asn Ala Ser Phe 
        195                 200                 205             


Gln Cys Met Ala Ala Gly Arg Ala Ala Glu Ala Glu Arg Phe Leu Leu 
    210                 215                 220                 


Gln Arg Gln Ser Gly Ala Leu Val Pro Ala Ala Gly Val Arg His Ile 
225                 230                 235                 240 


Ser His Arg Arg Phe Leu Ala Thr Phe Pro Leu Ala Ala Val Ser Arg 
                245                 250                 255     


Ala Glu Gln Asp Leu Tyr Arg Cys Val Ser Gln Ala Pro Arg Gly Ala 
            260                 265                 270         


Gly Val Ser Asn Phe Ala Glu Leu Ile Val Lys Glu Pro Pro Thr Pro 
        275                 280                 285             


Ile Ala Pro Pro Gln Leu Leu Arg Ala Gly Pro Thr Tyr Leu Ile Ile 
    290                 295                 300                 


Gln Leu Asn Thr Asn Ser Ile Ile Gly Asp Gly Pro Ile Val Arg Lys 
305                 310                 315                 320 


Glu Ile Glu Tyr Arg Met Ala Arg Gly Pro Trp Ala Glu Val His Ala 
                325                 330                 335     


Val Ser Leu Gln Thr Tyr Lys Leu Trp His Leu Asp Pro Asp Thr Glu 
            340                 345                 350         


Tyr Glu Ile Ser Val Leu Leu Thr Arg Pro Gly Asp Gly Gly Thr Gly 
        355                 360                 365             


Arg Pro Gly Pro Pro Leu Ile Ser Arg Thr Lys Cys Ala Glu Pro Met 
    370                 375                 380                 


Arg Ala Pro Lys Gly Leu Ala Phe Ala Glu Ile Gln Ala Arg Gln Leu 
385                 390                 395                 400 


Thr Leu Gln Trp Glu Pro Leu Gly Tyr Asn Val Thr Arg Cys His Thr 
                405                 410                 415     


Tyr Thr Val Ser Leu Cys Tyr His Tyr Thr Leu Gly Ser Ser His Asn 
            420                 425                 430         


Gln Thr Ile Arg Glu Cys Val Lys Thr Glu Gln Gly Val Ser Arg Tyr 
        435                 440                 445             


Thr Ile Lys Asn Leu Leu Pro Tyr Arg Asn Val His Val Arg Leu Val 
    450                 455                 460                 


Leu Thr Asn Pro Glu Gly Arg Lys Glu Gly Lys Glu Val Thr Phe Gln 
465                 470                 475                 480 


Thr Asp Glu Asp Val Pro Ser Gly Ile Ala Ala Glu Ser Leu Thr Phe 
                485                 490                 495     


Thr Pro Leu Glu Asp Met Ile Phe Leu Lys Trp Glu Glu Pro Gln Glu 
            500                 505                 510         


Pro Asn Gly Leu Ile Thr Gln Tyr Glu Ile Ser Tyr Gln Ser Ile Glu 
        515                 520                 525             


Ser Ser Asp Pro Ala Val Asn Val Pro Gly Pro Arg Arg Thr Ile Ser 
    530                 535                 540                 


Lys Leu Arg Asn Glu Thr Tyr His Val Phe Ser Asn Leu His Pro Gly 
545                 550                 555                 560 


Thr Thr Tyr Leu Phe Ser Val Arg Ala Arg Thr Gly Lys Gly Phe Gly 
                565                 570                 575     


Gln Ala Ala Leu Thr Glu Ile Thr Thr Asn Ile Ser Ala Pro Ser Phe 
            580                 585                 590         


Asp Tyr Ala Asp Met Pro Ser Pro Leu Gly Glu Ser Glu Asn Thr Ile 
        595                 600                 605             


Thr Val Leu Leu Arg Pro Ala Gln Gly Arg Gly Ala Pro Ile Ser Val 
    610                 615                 620                 


Tyr Gln Val Ile Val Glu Glu Glu Arg Ala Arg Arg Leu Arg Arg Glu 
625                 630                 635                 640 


Pro Gly Gly Gln Asp Cys Phe Pro Val Pro Leu Thr Phe Glu Ala Ala 
                645                 650                 655     


Leu Ala Arg Gly Leu Val His Tyr Phe Gly Ala Glu Leu Ala Ala Ser 
            660                 665                 670         


Ser Leu Pro Glu Ala Met Pro Phe Thr Val Gly Asp Asn Gln Thr Tyr 
        675                 680                 685             


Arg Gly Phe Trp Asn Pro Pro Leu Glu Pro Arg Lys Ala Tyr Leu Ile 
    690                 695                 700                 


Tyr Phe Gln Ala Ala Ser His Leu Lys Gly Glu Thr Arg Leu Asn Cys 
705                 710                 715                 720 


Ile Arg Ile Ala Arg Lys Ala Ala Cys Lys Glu Ser Lys Arg Pro Leu 
                725                 730                 735     


Glu Val Ser Gln Arg Ser Glu Glu Met Gly Leu Ile Leu Gly Ile Cys 
            740                 745                 750         


Ala Gly Gly Leu Ala Val Leu Ile Leu Leu Leu Gly Ala Ile Ile Val 
        755                 760                 765             


Ile Ile Arg Lys Gly Lys Pro Val Asn Met Thr Lys Ala Thr Val Asn 
    770                 775                 780                 


Tyr Arg Gln Glu Lys Thr His Met Met Ser Ala Val Asp Arg Ser Phe 
785                 790                 795                 800 


Thr Asp Gln Ser Thr Leu Gln Glu Asp Glu Arg Leu Gly Leu Ser Phe 
                805                 810                 815     


Met Asp Thr His Gly Tyr Ser Thr Arg Gly Asp Gln Arg Ser Gly Gly 
            820                 825                 830         


Val Thr Glu Ala Ser Ser Leu Leu Gly Gly Ser Pro Arg Arg Pro Cys 
        835                 840                 845             


Gly Arg Lys Gly Ser Pro Tyr His Thr Gly Gln Leu His Pro Ala Val 
    850                 855                 860                 


Arg Val Ala Asp Leu Leu Gln His Ile Asn Gln Met Lys Thr Ala Glu 
865                 870                 875                 880 


Gly Tyr Gly Phe Lys Gln Glu Tyr Glu Ser Phe Phe Glu Gly Trp Asp 
                885                 890                 895     


Ala Thr Lys Lys Lys Asp Lys Val Lys Gly Ser Arg Gln Glu Pro Met 
            900                 905                 910         


Pro Ala Tyr Asp Arg His Arg Val Lys Leu His Pro Met Leu Gly Asp 
        915                 920                 925             


Pro Asn Ala Asp Tyr Ile Asn Ala Asn Tyr Ile Asp Gly Tyr His Arg 
    930                 935                 940                 


Ser Asn His Phe Ile Ala Thr Gln Gly Pro Lys Pro Glu Met Val Tyr 
945                 950                 955                 960 


Asp Phe Trp Arg Met Val Trp Gln Glu His Cys Ser Ser Ile Val Met 
                965                 970                 975     


Ile Thr Lys Leu Val Glu Val Gly Arg Val Lys Cys Ser Arg Tyr Trp 
            980                 985                 990         


Pro Glu Asp Ser Asp Thr Tyr Gly  Asp Ile Lys Ile Met  Leu Val Lys 
        995                 1000                 1005             


Thr Glu  Thr Leu Ala Glu Tyr  Val Val Arg Thr Phe  Ala Leu Glu 
    1010                 1015                 1020             


Arg Arg  Gly Tyr Ser Ala Arg  His Glu Val Arg Gln  Phe His Phe 
    1025                 1030                 1035             


Thr Ala  Trp Pro Glu His Gly  Val Pro Tyr His Ala  Thr Gly Leu 
    1040                 1045                 1050             


Leu Ala  Phe Ile Arg Arg Val  Lys Ala Ser Thr Pro  Pro Asp Ala 
    1055                 1060                 1065             


Gly Pro  Ile Val Ile His Cys  Ser Ala Gly Thr Gly  Arg Thr Gly 
    1070                 1075                 1080             


Cys Tyr  Ile Val Leu Asp Val  Met Leu Asp Met Ala  Glu Cys Glu 
    1085                 1090                 1095             


Gly Val  Val Asp Ile Tyr Asn  Cys Val Lys Thr Leu  Cys Ser Arg 
    1100                 1105                 1110             


Arg Val  Asn Met Ile Gln Thr  Glu Glu Gln Tyr Ile  Phe Ile His 
    1115                 1120                 1125             


Asp Ala  Ile Leu Glu Ala Cys  Leu Cys Gly Glu Thr  Thr Ile Pro 
    1130                 1135                 1140             


Val Ser  Glu Phe Lys Ala Thr  Tyr Lys Glu Met Ile  Arg Ile Asp 
    1145                 1150                 1155             


Pro Gln  Ser Asn Ser Ser Gln  Leu Arg Glu Glu Phe  Gln Thr Leu 
    1160                 1165                 1170             


Asn Ser  Val Thr Pro Pro Leu  Asp Val Glu Glu Cys  Ser Ile Ala 
    1175                 1180                 1185             


Leu Leu  Pro Arg Asn Arg Asp  Lys Asn Arg Ser Met  Asp Val Leu 
    1190                 1195                 1200             


Pro Pro  Asp Arg Cys Leu Pro  Phe Leu Ile Ser Thr  Asp Gly Asp 
    1205                 1210                 1215             


Ser Asn  Asn Tyr Ile Asn Ala  Ala Leu Thr Asp Ser  Tyr Thr Arg 
    1220                 1225                 1230             


Ser Ala  Ala Phe Ile Val Thr  Leu His Pro Leu Gln  Ser Thr Thr 
    1235                 1240                 1245             


Pro Asp  Phe Trp Arg Leu Val  Tyr Asp Tyr Gly Cys  Thr Ser Ile 
    1250                 1255                 1260             


Val Met  Leu Asn Gln Leu Asn  Gln Ser Asn Ser Ala  Trp Pro Cys 
    1265                 1270                 1275             


Leu Gln  Tyr Trp Pro Glu Pro  Gly Arg Gln Gln Tyr  Gly Leu Met 
    1280                 1285                 1290             


Glu Val  Glu Phe Met Ser Gly  Thr Ala Asp Glu Asp  Leu Val Ala 
    1295                 1300                 1305             


Arg Val  Phe Arg Val Gln Asn  Ile Ser Arg Leu Gln  Glu Gly His 
    1310                 1315                 1320             


Leu Leu  Val Arg His Phe Gln  Phe Leu Arg Trp Ser  Ala Tyr Arg 
    1325                 1330                 1335             


Asp Thr  Pro Asp Ser Lys Lys  Ala Phe Leu His Leu  Leu Ala Glu 
    1340                 1345                 1350             


Val Asp  Lys Trp Gln Ala Glu  Ser Gly Asp Gly Arg  Thr Ile Val 
    1355                 1360                 1365             


His Cys  Leu Asn Gly Gly Gly  Arg Ser Gly Thr Phe  Cys Ala Cys 
    1370                 1375                 1380             


Ala Thr  Val Leu Glu Met Ile  Arg Cys His Asn Leu  Val Asp Val 
    1385                 1390                 1395             


Phe Phe  Ala Ala Lys Thr Leu  Arg Asn Tyr Lys Pro  Asn Met Val 
    1400                 1405                 1410             


Glu Thr  Met Asp Gln Tyr His  Phe Cys Tyr Asp Val  Ala Leu Glu 
    1415                 1420                 1425             


Tyr Leu  Glu Gly Leu Glu Ser  Arg 
    1430                 1435     


<210>  5679
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  5679

Met Asp Pro Lys Gln Thr Thr Leu Leu Cys Leu Val Leu Cys Leu Gly 
1               5                   10                  15      


Gln Arg Ile Gln Ala Gln Glu Gly Asp Phe Pro Met Pro Phe Ile Ser 
            20                  25                  30          


Ala Lys Ser Ser Pro Val Ile Pro Leu Asp Gly Ser Val Lys Ile Gln 
        35                  40                  45              


Cys Gln Ala Ile Arg Glu Ala Tyr Leu Thr Gln Leu Met Ile Ile Lys 
    50                  55                  60                  


Asn Ser Thr Tyr Arg Glu Ile Gly Arg Arg Leu Lys Phe Trp Asn Glu 
65                  70                  75                  80  


Thr Asp Pro Glu Phe Val Ile Asp His Met Asp Ala Asn Lys Ala Gly 
                85                  90                  95      


Arg Tyr Gln Cys Gln Tyr Arg Ile Gly His Tyr Arg Phe Arg Tyr Ser 
            100                 105                 110         


Asp Thr Leu Glu Leu Val Val Thr Gly Leu Tyr Gly Lys Pro Phe Leu 
        115                 120                 125             


Ser Ala Asp Arg Gly Leu Val Leu Met Pro Gly Glu Asn Ile Ser Leu 
    130                 135                 140                 


Thr Cys Ser Ser Ala His Ile Pro Phe Asp Arg Phe Ser Leu Ala Lys 
145                 150                 155                 160 


Glu Gly Glu Leu Ser Leu Pro Gln His Gln Ser Gly Glu His Pro Ala 
                165                 170                 175     


Asn Phe Ser Leu Gly Pro Val Asp Leu Asn Val Ser Gly Ile Tyr Arg 
            180                 185                 190         


Cys Tyr Asp Ser Ile His Gln Asp Tyr Thr Thr Gln Asn Leu Ile Arg 
        195                 200                 205             


Met Ala Val Ala Gly Leu Val Leu Val Ala Leu Leu Ala Ile Leu Val 
    210                 215                 220                 


Glu Asn Trp His Ser His Thr Ala Leu Asn Lys Glu Ala Ser Ala Asp 
225                 230                 235                 240 


Val Ala Glu Pro Ser Trp Ser Gln Gln Met Cys Gln Pro Gly Leu Thr 
                245                 250                 255     


Phe Ala Arg Thr Pro Ser Val Cys Lys 
            260                 265 


<210>  5680
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  5680

Met Asp Pro Lys Gln Thr Thr Leu Leu Cys Leu Val Leu Cys Leu Gly 
1               5                   10                  15      


Gln Arg Ile Gln Ala Gln Glu Gly Asp Phe Pro Met Pro Phe Ile Ser 
            20                  25                  30          


Ala Lys Ser Ser Pro Val Ile Pro Leu Asp Gly Ser Val Lys Ile Gln 
        35                  40                  45              


Cys Gln Ala Ile Arg Glu Ala Tyr Leu Thr Gln Leu Met Ile Ile Lys 
    50                  55                  60                  


Asn Ser Thr Tyr Arg Glu Ile Gly Arg Arg Leu Lys Phe Trp Asn Glu 
65                  70                  75                  80  


Thr Asp Pro Glu Phe Val Ile Asp His Met Asp Ala Asn Lys Ala Gly 
                85                  90                  95      


Arg Tyr Gln Cys Gln Tyr Arg Ile Gly His Tyr Arg Phe Arg Tyr Ser 
            100                 105                 110         


Asp Thr Leu Glu Leu Val Val Thr Asp Ser Ile His Gln Asp Tyr Thr 
        115                 120                 125             


Thr Gln Asn Leu Ile Arg Met Ala Val Ala Gly Leu Val Leu Val Ala 
    130                 135                 140                 


Leu Leu Ala Ile Leu Val Glu Asn Trp His Ser His Thr Ala Leu Asn 
145                 150                 155                 160 


Lys Glu Ala Ser Ala Asp Val Ala Glu Pro Ser Trp Ser Gln Gln Met 
                165                 170                 175     


Cys Gln Pro Gly Leu Thr Phe Ala Arg Thr Pro Ser Val Cys Lys 
            180                 185                 190     


<210>  5681
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  5681

Met Asp Pro Lys Gln Thr Thr Leu Leu Cys Leu Gly Asp Phe Pro Met 
1               5                   10                  15      


Pro Phe Ile Ser Ala Lys Ser Ser Pro Val Ile Pro Leu Asp Gly Ser 
            20                  25                  30          


Val Lys Ile Gln Cys Gln Ala Ile Arg Glu Ala Tyr Leu Thr Gln Leu 
        35                  40                  45              


Met Ile Ile Lys Asn Ser Thr Tyr Arg Glu Ile Gly Arg Arg Leu Lys 
    50                  55                  60                  


Phe Trp Asn Glu Thr Asp Pro Glu Phe Val Ile Asp His Met Asp Ala 
65                  70                  75                  80  


Asn Lys Ala Gly Arg Tyr Gln Cys Gln Tyr Arg Ile Gly His Tyr Arg 
                85                  90                  95      


Phe Arg Tyr Ser Asp Thr Leu Glu Leu Val Val Thr Gly Leu Tyr Gly 
            100                 105                 110         


Lys Pro Phe Leu Ser Ala Asp Arg Gly Leu Val Leu Met Pro Gly Glu 
        115                 120                 125             


Asn Ile Ser Leu Thr Cys Ser Ser Ala His Ile Pro Phe Asp Arg Phe 
    130                 135                 140                 


Ser Leu Ala Lys Glu Gly Glu Leu Ser Leu Pro Gln His Gln Ser Gly 
145                 150                 155                 160 


Glu His Pro Ala Asn Phe Ser Leu Gly Pro Val Asp Leu Asn Val Ser 
                165                 170                 175     


Gly Ile Tyr Arg Cys Tyr Gly Trp Tyr Asn Arg Ser Pro Tyr Leu Trp 
            180                 185                 190         


Ser Phe Pro Ser Asn Ala Leu Glu Leu Val Val Thr Asp Ser Ile His 
        195                 200                 205             


Gln Asp Tyr Thr Thr Gln Asn Leu Ile Arg Met Ala Val Ala Gly Leu 
    210                 215                 220                 


Val Leu Val Ala Leu Leu Ala Ile Leu Val Glu Asn Trp His Ser His 
225                 230                 235                 240 


Thr Ala Leu Asn Lys Glu Ala Ser Ala Asp Val Ala Glu Pro Ser Trp 
                245                 250                 255     


Ser Gln Gln Met Cys Gln Pro Gly Leu Thr Phe Ala Arg Thr Pro Ser 
            260                 265                 270         


Val Cys Lys 
        275 


<210>  5682
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  5682

Met Asp Pro Lys Gln Thr Thr Leu Leu Cys Leu Gly Asp Phe Pro Met 
1               5                   10                  15      


Pro Phe Ile Ser Ala Lys Ser Ser Pro Val Ile Pro Leu Asp Gly Ser 
            20                  25                  30          


Val Lys Ile Gln Cys Gln Ala Ile Arg Glu Ala Tyr Leu Thr Gln Leu 
        35                  40                  45              


Met Ile Ile Lys Asn Ser Thr Tyr Arg Glu Ile Gly Arg Arg Leu Lys 
    50                  55                  60                  


Phe Trp Asn Glu Thr Asp Pro Glu Phe Val Ile Asp His Met Asp Ala 
65                  70                  75                  80  


Asn Lys Ala Gly Arg Tyr Gln Cys Gln Tyr Arg Ile Gly His Tyr Arg 
                85                  90                  95      


Phe Arg Tyr Ser Asp Thr Leu Glu Leu Val Val Thr Asp Ser Ile His 
            100                 105                 110         


Gln Asp Tyr Thr Thr Gln Asn Leu Ile Arg Met Ala Val Ala Gly Leu 
        115                 120                 125             


Val Leu Val Ala Leu Leu Ala Ile Leu Val Glu Asn Trp His Ser His 
    130                 135                 140                 


Thr Ala Leu Asn Lys Glu Ala Ser Ala Asp Val Ala Glu Pro Ser Trp 
145                 150                 155                 160 


Ser Gln Gln Met Cys Gln Pro Gly Leu Thr Phe Ala Arg Thr Pro Ser 
                165                 170                 175     


Val Cys Lys 
            


<210>  5683
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  5683

Met Asp Pro Lys Gln Thr Thr Leu Leu Cys Leu Gly Asp Phe Pro Met 
1               5                   10                  15      


Pro Phe Ile Ser Ala Lys Ser Ser Pro Val Ile Pro Leu Asp Gly Ser 
            20                  25                  30          


Val Lys Ile Gln Cys Gln Ala Ile Arg Glu Ala Tyr Leu Thr Gln Leu 
        35                  40                  45              


Met Ile Ile Lys Asn Ser Thr Tyr Arg Glu Ile Gly Arg Arg Leu Lys 
    50                  55                  60                  


Phe Trp Asn Glu Thr Asp Pro Glu Phe Val Ile Asp His Met Asp Ala 
65                  70                  75                  80  


Asn Lys Ala Gly Arg Tyr Gln Cys Gln Tyr Arg Ile Gly His Tyr Arg 
                85                  90                  95      


Phe Arg Tyr Ser Asp Thr Leu Glu Leu Val Val Thr Gly Leu Tyr Gly 
            100                 105                 110         


Lys Pro Phe Leu Ser Ala Asp Arg Gly Leu Val Leu Met Pro Gly Glu 
        115                 120                 125             


Asn Ile Ser Leu Thr Cys Ser Ser Ala His Ile Pro Phe Asp Arg Phe 
    130                 135                 140                 


Ser Leu Ala Lys Glu Gly Glu Leu Ser Leu Pro Gln His Gln Ser Gly 
145                 150                 155                 160 


Glu His Pro Ala Asn Phe Ser Leu Gly Pro Val Asp Leu Asn Val Ser 
                165                 170                 175     


Gly Ile Tyr Arg Leu His Pro Pro Arg Leu His Asp Ala Glu Leu Asp 
            180                 185                 190         


Pro His Gly Arg Gly Arg Thr Gly Pro Arg Gly Ser Leu Gly His Thr 
        195                 200                 205             


Gly 
    


<210>  5684
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  5684

Met Asp Pro Lys Gln Thr Thr Leu Leu Cys Leu Gly Leu Tyr Gly Lys 
1               5                   10                  15      


Pro Phe Leu Ser Ala Asp Arg Gly Leu Val Leu Met Pro Gly Glu Asn 
            20                  25                  30          


Ile Ser Leu Thr Cys Ser Ser Ala His Ile Pro Phe Asp Arg Phe Ser 
        35                  40                  45              


Leu Ala Lys Glu Gly Glu Leu Ser Leu Pro Gln His Gln Ser Gly Glu 
    50                  55                  60                  


His Pro Ala Asn Phe Ser Leu Gly Pro Val Asp Leu Asn Val Ser Gly 
65                  70                  75                  80  


Ile Tyr Arg Cys Tyr Gly Trp Tyr Asn Arg Ser Pro Tyr Leu Trp Ser 
                85                  90                  95      


Phe Pro Ser Asn Ala Leu Glu Leu Val Val Thr Asp Ser Ile His Gln 
            100                 105                 110         


Asp Tyr Thr Thr Gln Asn Leu Ile Arg Met Ala Val Ala Gly Leu Val 
        115                 120                 125             


Leu Val Ala Leu Leu Ala Ile Leu Val Glu Asn Trp His Ser His Thr 
    130                 135                 140                 


Ala Leu Asn Lys Glu Ala Ser Ala Asp Val Ala Glu Pro Ser Trp Ser 
145                 150                 155                 160 


Gln Gln Met Cys Gln Pro Gly Leu Thr Phe Ala Arg Thr Pro Ser Val 
                165                 170                 175     


Cys Lys 
        


<210>  5685
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  5685

Met Asp Pro Lys Gln Thr Thr Leu Leu Cys Leu Gly Asp Phe Pro Met 
1               5                   10                  15      


Pro Phe Ile Ser Ala Lys Ser Ser Pro Val Ile Pro Leu Asp Gly Ser 
            20                  25                  30          


Val Lys Ile Gln Cys Gln Ala Ile Arg Glu Ala Tyr Leu Thr Gln Leu 
        35                  40                  45              


Met Ile Ile Lys Asn Ser Thr Tyr Arg Glu Ile Gly Arg Arg Leu Lys 
    50                  55                  60                  


Phe Trp Asn Glu Thr Asp Pro Glu Phe Val Ile Asp His Met Asp Ala 
65                  70                  75                  80  


Asn Lys Ala Gly Arg Tyr Gln Cys Gln Tyr Arg Ile Gly His Tyr Arg 
                85                  90                  95      


Phe Arg Tyr Ser Asp Thr Leu Glu Leu Val Val Thr Gly Leu Tyr Gly 
            100                 105                 110         


Lys Pro Phe Leu Ser Ala Asp Arg Gly Leu Val Leu Met Pro Gly Glu 
        115                 120                 125             


Asn Ile Ser Leu Thr Cys Ser Ser Ala His Ile Pro Phe Asp Arg Phe 
    130                 135                 140                 


Ser Leu Ala Lys Glu Gly Glu Leu Ser Leu Pro Gln His Gln Ser Gly 
145                 150                 155                 160 


Glu His Pro Ala Asn Phe Ser Leu Gly Pro Val Asp Leu Asn Val Ser 
                165                 170                 175     


Gly Ile Tyr Arg Cys Tyr Asp Ser Ile His Gln Asp Tyr Thr Thr Gln 
            180                 185                 190         


Asn Leu Ile Arg Met Ala Val Ala Gly Leu Val Leu Val Ala Leu Leu 
        195                 200                 205             


Ala Ile Leu Val Glu Asn Trp His Ser His Thr Ala Leu Asn Lys Glu 
    210                 215                 220                 


Ala Ser Ala Asp Val Ala Glu Pro Ser Trp Ser Gln Gln Met Cys Gln 
225                 230                 235                 240 


Pro Gly Leu Thr Phe Ala Arg Thr Pro Ser Val Cys Lys 
                245                 250             


<210>  5686
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  5686

Met Asp Pro Lys Gln Thr Thr Leu Leu Cys Leu Gly Asp Phe Pro Met 
1               5                   10                  15      


Pro Phe Ile Ser Ala Lys Ser Ser Pro Val Ile Pro Leu Asp Gly Ser 
            20                  25                  30          


Val Lys Ile Gln Cys Gln Ala Ile Arg Glu Ala Tyr Leu Thr Gln Leu 
        35                  40                  45              


Met Ile Ile Lys Asn Ser Thr Tyr Arg Glu Ile Gly Arg Arg Leu Lys 
    50                  55                  60                  


Phe Trp Asn Glu Thr Asp Pro Glu Phe Val Ile Asp His Met Asp Ala 
65                  70                  75                  80  


Asn Lys Ala Gly Arg Tyr Gln Cys Gln Tyr Arg Ile Gly His Tyr Arg 
                85                  90                  95      


Phe Arg Tyr Ser Asp Thr Leu Glu Leu Val Val Thr Gly Leu Tyr Gly 
            100                 105                 110         


Lys Pro Phe Leu Ser Ala Asp Arg Gly Leu Val Leu Met Pro Gly Glu 
        115                 120                 125             


Asn Ile Ser Leu Thr Cys Ser Ser Ala His Ile Pro Phe Asp Arg Phe 
    130                 135                 140                 


Ser Leu Ala Lys Glu Gly Glu Leu Ser Leu Pro Gln His Gln Ser Gly 
145                 150                 155                 160 


Glu His Pro Ala Asn Phe Ser Leu Gly Pro Val Asp Leu Asn Val Ser 
                165                 170                 175     


Gly Ile Tyr Arg Cys Tyr Asp Ser Ile His Gln Asp Tyr Thr Thr Gln 
            180                 185                 190         


Asn Leu Ile Arg Met Ala Val Ala Gly Leu Val Leu Val Ala Leu Leu 
        195                 200                 205             


Ala Ile Leu Val Glu Asn Trp His Ser His Thr Ala Leu Asn Lys Glu 
    210                 215                 220                 


Ala Ser Ala Asp Val Ala Glu Pro Ser Trp Ser Gln Gln Met Cys Gln 
225                 230                 235                 240 


Pro Gly Leu Thr Phe Ala Arg Thr Pro Ser Val Cys Lys 
                245                 250             


<210>  5687
<211>  436
<212>  PRT
<213>  Homo sapiens

<400>  5687

Met Thr Phe Gly Arg Ser Gly Ala Ala Ser Val Val Leu Asn Val Gly 
1               5                   10                  15      


Gly Ala Arg Tyr Ser Leu Ser Arg Glu Leu Leu Lys Asp Phe Pro Leu 
            20                  25                  30          


Arg Arg Val Ser Arg Leu His Gly Cys Arg Ser Glu Arg Asp Val Leu 
        35                  40                  45              


Glu Val Cys Asp Asp Tyr Asp Arg Glu Arg Asn Glu Tyr Phe Phe Asp 
    50                  55                  60                  


Arg His Ser Glu Ala Phe Gly Phe Ile Leu Leu Tyr Val Arg Gly His 
65                  70                  75                  80  


Gly Lys Leu Arg Phe Ala Pro Arg Met Cys Glu Leu Ser Phe Tyr Asn 
                85                  90                  95      


Glu Met Ile Tyr Trp Gly Leu Glu Gly Ala His Leu Glu Tyr Cys Cys 
            100                 105                 110         


Gln Arg Arg Leu Asp Asp Arg Met Ser Asp Thr Tyr Thr Phe Tyr Ser 
        115                 120                 125             


Ala Asp Glu Pro Gly Val Leu Gly Arg Asp Glu Ala Arg Pro Gly Gly 
    130                 135                 140                 


Ala Glu Ala Ala Pro Ser Arg Arg Trp Leu Glu Arg Met Arg Arg Thr 
145                 150                 155                 160 


Phe Glu Glu Pro Thr Ser Ser Leu Ala Ala Gln Ile Leu Ala Ser Val 
                165                 170                 175     


Ser Val Val Phe Val Ile Val Ser Met Val Val Leu Cys Ala Ser Thr 
            180                 185                 190         


Leu Pro Asp Trp Arg Asn Ala Ala Ala Asp Asn Arg Ser Leu Asp Asp 
        195                 200                 205             


Arg Ser Arg Tyr Ser Ala Gly Pro Gly Arg Glu Pro Ser Gly Ile Ile 
    210                 215                 220                 


Glu Ala Ile Cys Ile Gly Trp Phe Thr Ala Glu Cys Ile Val Arg Phe 
225                 230                 235                 240 


Ile Val Ser Lys Asn Lys Cys Glu Phe Val Lys Arg Pro Leu Asn Ile 
                245                 250                 255     


Ile Asp Leu Leu Ala Ile Thr Pro Tyr Tyr Ile Ser Val Leu Met Thr 
            260                 265                 270         


Val Phe Thr Gly Glu Asn Ser Gln Leu Gln Arg Ala Gly Val Thr Leu 
        275                 280                 285             


Arg Val Leu Arg Met Met Arg Ile Phe Trp Val Ile Lys Leu Ala Arg 
    290                 295                 300                 


His Phe Ile Gly Leu Gln Thr Leu Gly Leu Thr Leu Lys Arg Cys Tyr 
305                 310                 315                 320 


Arg Glu Met Val Met Leu Leu Val Phe Ile Cys Val Ala Met Ala Ile 
                325                 330                 335     


Phe Ser Ala Leu Ser Gln Leu Leu Glu His Gly Leu Asp Leu Glu Thr 
            340                 345                 350         


Ser Asn Lys Asp Phe Thr Ser Ile Pro Ala Ala Cys Trp Trp Val Ile 
        355                 360                 365             


Ile Ser Met Thr Thr Val Gly Tyr Gly Asp Met Tyr Pro Ile Thr Val 
    370                 375                 380                 


Pro Gly Arg Ile Leu Gly Gly Val Cys Val Val Ser Gly Ile Val Leu 
385                 390                 395                 400 


Leu Ala Leu Pro Ile Thr Phe Ile Tyr His Ser Phe Val Gln Cys Tyr 
                405                 410                 415     


His Glu Leu Lys Phe Arg Ser Ala Arg Tyr Ser Arg Ser Leu Ser Thr 
            420                 425                 430         


Glu Phe Leu Asn 
        435     


<210>  5688
<211>  2048
<212>  PRT
<213>  Homo sapiens

<400>  5688

Met Leu Arg Val Ile Val Glu Ser Ala Ser Asn Ile Pro Lys Thr Lys 
1               5                   10                  15      


Phe Gly Lys Pro Asp Pro Ile Val Ser Val Ile Phe Lys Asp Glu Lys 
            20                  25                  30          


Lys Lys Thr Lys Lys Val Asp Asn Glu Leu Asn Pro Val Trp Asn Glu 
        35                  40                  45              


Ile Leu Glu Phe Asp Leu Arg Gly Ile Pro Leu Asp Phe Ser Ser Ser 
    50                  55                  60                  


Leu Gly Ile Ile Val Lys Asp Phe Glu Thr Ile Gly Gln Asn Lys Leu 
65                  70                  75                  80  


Ile Gly Thr Ala Thr Val Ala Leu Lys Asp Leu Thr Gly Asp Gln Ser 
                85                  90                  95      


Arg Ser Leu Pro Tyr Lys Leu Ile Ser Leu Leu Asn Glu Lys Gly Gln 
            100                 105                 110         


Asp Thr Gly Ala Thr Ile Asp Leu Val Ile Gly Tyr Asp Pro Pro Ser 
        115                 120                 125             


Ala Pro His Pro Asn Asp Leu Ser Gly Pro Ser Val Pro Gly Met Gly 
    130                 135                 140                 


Gly Asp Gly Glu Glu Asp Glu Gly Asp Glu Asp Arg Leu Asp Asn Ala 
145                 150                 155                 160 


Val Arg Gly Pro Gly Pro Lys Gly Pro Val Gly Thr Val Ser Glu Ala 
                165                 170                 175     


Gln Leu Ala Arg Arg Leu Thr Lys Val Lys Asn Ser Arg Arg Met Leu 
            180                 185                 190         


Ser Asn Lys Pro Gln Asp Phe Gln Ile Arg Val Arg Val Ile Glu Gly 
        195                 200                 205             


Arg Gln Leu Ser Gly Asn Asn Ile Arg Pro Val Val Lys Val His Val 
    210                 215                 220                 


Cys Gly Gln Thr His Arg Thr Arg Ile Lys Arg Gly Asn Asn Pro Phe 
225                 230                 235                 240 


Phe Asp Glu Leu Phe Phe Tyr Asn Val Asn Met Thr Pro Ser Glu Leu 
                245                 250                 255     


Met Asp Glu Ile Ile Ser Ile Arg Val Tyr Asn Ser His Ser Leu Arg 
            260                 265                 270         


Ala Asp Cys Leu Met Gly Glu Phe Lys Ile Asp Val Gly Phe Val Tyr 
        275                 280                 285             


Asp Glu Pro Gly His Ala Val Met Arg Lys Trp Leu Leu Leu Asn Asp 
    290                 295                 300                 


Pro Glu Asp Thr Ser Ser Gly Ser Lys Gly Tyr Met Lys Val Ser Met 
305                 310                 315                 320 


Phe Val Leu Gly Thr Gly Asp Glu Pro Pro Pro Glu Arg Arg Asp Arg 
                325                 330                 335     


Asp Asn Asp Ser Asp Asp Val Glu Ser Asn Leu Leu Leu Pro Ala Gly 
            340                 345                 350         


Ile Ala Leu Arg Trp Val Thr Phe Leu Leu Lys Ile Tyr Arg Ala Glu 
        355                 360                 365             


Asp Ile Pro Gln Met Asp Asp Ala Phe Ser Gln Thr Val Lys Glu Ile 
    370                 375                 380                 


Phe Gly Gly Asn Ala Asp Lys Lys Asn Leu Val Asp Pro Phe Val Glu 
385                 390                 395                 400 


Val Ser Phe Ala Gly Lys Lys Val Cys Thr Asn Ile Ile Glu Lys Asn 
                405                 410                 415     


Ala Asn Pro Glu Trp Asn Gln Val Val Asn Leu Gln Ile Lys Phe Pro 
            420                 425                 430         


Ser Val Cys Glu Lys Ile Lys Leu Thr Ile Tyr Asp Trp Asp Arg Leu 
        435                 440                 445             


Thr Lys Asn Asp Val Val Gly Thr Thr Tyr Leu His Leu Ser Lys Ile 
    450                 455                 460                 


Ala Ala Ser Gly Gly Glu Val Glu Val Asn Thr Gly Glu Thr Glu Val 
465                 470                 475                 480 


Gly Phe Val Pro Thr Phe Gly Pro Cys Tyr Leu Asn Leu Tyr Gly Ser 
                485                 490                 495     


Pro Arg Glu Tyr Thr Gly Phe Pro Asp Pro Tyr Asp Glu Leu Asn Thr 
            500                 505                 510         


Gly Lys Gly Glu Gly Val Ala Tyr Arg Gly Arg Ile Leu Val Glu Leu 
        515                 520                 525             


Ala Thr Phe Leu Glu Lys Thr Pro Pro Asp Lys Lys Leu Glu Pro Ile 
    530                 535                 540                 


Ser Asn Asp Asp Leu Leu Val Val Glu Lys Tyr Gln Arg Arg Arg Lys 
545                 550                 555                 560 


Tyr Ser Leu Ser Ala Val Phe His Ser Ala Thr Met Leu Gln Asp Val 
                565                 570                 575     


Gly Glu Ala Ile Gln Phe Glu Val Ser Ile Gly Asn Tyr Gly Asn Lys 
            580                 585                 590         


Phe Asp Thr Thr Cys Lys Pro Leu Ala Ser Thr Thr Gln Tyr Ser Arg 
        595                 600                 605             


Ala Val Phe Asp Gly Asn Tyr Tyr Tyr Tyr Leu Pro Trp Ala His Thr 
    610                 615                 620                 


Lys Pro Val Val Thr Leu Thr Ser Tyr Trp Glu Asp Ile Ser His Arg 
625                 630                 635                 640 


Leu Asp Ala Val Asn Thr Leu Leu Ala Met Ala Glu Arg Leu Gln Thr 
                645                 650                 655     


Asn Ile Glu Ala Leu Lys Ser Gly Ile Gln Gly Lys Ile Pro Ala Asn 
            660                 665                 670         


Gln Leu Ala Glu Leu Trp Leu Lys Leu Ile Asp Glu Val Ile Glu Asp 
        675                 680                 685             


Thr Arg Tyr Thr Leu Pro Leu Thr Glu Gly Lys Ala Asn Val Thr Val 
    690                 695                 700                 


Leu Asp Thr Gln Ile Arg Lys Leu Arg Ser Arg Ser Leu Ser Gln Ile 
705                 710                 715                 720 


His Glu Ala Ala Val Arg Met Arg Ser Glu Ala Thr Asp Val Lys Ser 
                725                 730                 735     


Thr Leu Ala Glu Ile Glu Asp Trp Leu Asp Lys Leu Met Gln Leu Thr 
            740                 745                 750         


Glu Glu Pro Gln Asn Ser Met Pro Asp Ile Ile Ile Trp Met Ile Arg 
        755                 760                 765             


Gly Glu Lys Arg Leu Ala Tyr Ala Arg Ile Pro Ala His Gln Val Leu 
    770                 775                 780                 


Tyr Ser Thr Ser Gly Glu Asn Ala Ser Gly Lys Tyr Cys Gly Lys Thr 
785                 790                 795                 800 


Gln Thr Ile Phe Leu Lys Tyr Pro Gln Glu Lys Asn Asn Gly Pro Lys 
                805                 810                 815     


Val Pro Val Glu Leu Arg Val Asn Ile Trp Leu Gly Leu Ser Ala Val 
            820                 825                 830         


Glu Lys Lys Phe Asn Ser Phe Ala Glu Gly Thr Phe Thr Val Phe Ala 
        835                 840                 845             


Glu Met Tyr Glu Asn Gln Ala Leu Met Phe Gly Lys Trp Gly Thr Ser 
    850                 855                 860                 


Gly Leu Val Gly Arg His Lys Phe Ser Asp Val Thr Gly Lys Ile Lys 
865                 870                 875                 880 


Leu Lys Arg Glu Phe Phe Leu Pro Pro Lys Gly Trp Glu Trp Glu Gly 
                885                 890                 895     


Glu Trp Ile Val Asp Pro Glu Arg Ser Leu Leu Thr Glu Ala Asp Ala 
            900                 905                 910         


Gly His Thr Glu Phe Thr Asp Glu Val Tyr Gln Asn Glu Ser Arg Tyr 
        915                 920                 925             


Pro Gly Gly Asp Trp Lys Pro Ala Glu Asp Thr Tyr Thr Asp Ala Asn 
    930                 935                 940                 


Gly Asp Lys Ala Ala Ser Pro Ser Glu Leu Thr Cys Pro Pro Gly Trp 
945                 950                 955                 960 


Glu Trp Glu Asp Asp Ala Trp Ser Tyr Asp Ile Asn Arg Ala Val Asp 
                965                 970                 975     


Glu Lys Gly Trp Glu Tyr Gly Ile Thr Ile Pro Pro Asp His Lys Pro 
            980                 985                 990         


Lys Ser Trp Val Ala Ala Glu Lys  Met Tyr His Thr His  Arg Arg Arg 
        995                 1000                 1005             


Arg Leu  Val Arg Lys Arg Lys  Lys Asp Leu Thr Gln  Thr Ala Ser 
    1010                 1015                 1020             


Ser Thr  Ala Arg Ala Met Glu  Glu Leu Gln Asp Gln  Glu Gly Trp 
    1025                 1030                 1035             


Glu Tyr  Ala Ser Leu Ile Gly  Trp Lys Phe His Trp  Lys Gln Arg 
    1040                 1045                 1050             


Ser Ser  Asp Thr Phe Arg Arg  Arg Arg Trp Arg Arg  Lys Met Ala 
    1055                 1060                 1065             


Pro Ser  Glu Thr His Gly Ala  Ala Ala Ile Phe Lys  Leu Glu Gly 
    1070                 1075                 1080             


Ala Leu  Gly Ala Asp Thr Thr  Glu Asp Gly Asp Glu  Lys Ser Leu 
    1085                 1090                 1095             


Glu Lys  Gln Lys His Ser Ala  Thr Thr Val Phe Gly  Ala Asn Thr 
    1100                 1105                 1110             


Pro Ile  Val Ser Cys Asn Phe  Asp Arg Val Tyr Ile  Tyr His Leu 
    1115                 1120                 1125             


Arg Cys  Tyr Val Tyr Gln Ala  Arg Asn Leu Leu Ala  Leu Asp Lys 
    1130                 1135                 1140             


Asp Ser  Phe Ser Asp Pro Tyr  Ala His Ile Cys Phe  Leu His Arg 
    1145                 1150                 1155             


Ser Lys  Thr Thr Glu Ile Ile  His Ser Thr Leu Asn  Pro Thr Trp 
    1160                 1165                 1170             


Asp Gln  Thr Ile Ile Phe Asp  Glu Val Glu Ile Tyr  Gly Glu Pro 
    1175                 1180                 1185             


Gln Thr  Val Leu Gln Asn Pro  Pro Lys Val Ile Met  Glu Leu Phe 
    1190                 1195                 1200             


Asp Asn  Asp Gln Val Gly Lys  Asp Glu Phe Leu Gly  Arg Ser Ile 
    1205                 1210                 1215             


Phe Ser  Pro Val Val Lys Leu  Asn Ser Glu Met Asp  Ile Thr Pro 
    1220                 1225                 1230             


Lys Leu  Leu Trp His Pro Val  Met Asn Gly Asp Lys  Ala Cys Gly 
    1235                 1240                 1245             


Asp Val  Leu Val Thr Ala Glu  Leu Ile Leu Arg Gly  Lys Asp Gly 
    1250                 1255                 1260             


Ser Asn  Leu Pro Ile Leu Pro  Pro Gln Arg Ala Pro  Asn Leu Tyr 
    1265                 1270                 1275             


Met Val  Pro Gln Gly Ile Arg  Pro Val Val Gln Leu  Thr Ala Ile 
    1280                 1285                 1290             


Glu Ile  Leu Ala Trp Gly Leu  Arg Asn Met Lys Asn  Phe Gln Met 
    1295                 1300                 1305             


Ala Ser  Ile Thr Ser Pro Ser  Leu Val Val Glu Cys  Gly Gly Glu 
    1310                 1315                 1320             


Arg Val  Glu Ser Val Val Ile  Lys Asn Leu Lys Lys  Thr Pro Asn 
    1325                 1330                 1335             


Phe Pro  Ser Ser Val Leu Phe  Met Lys Val Phe Leu  Pro Lys Glu 
    1340                 1345                 1350             


Glu Leu  Tyr Met Pro Pro Leu  Val Ile Lys Val Ile  Asp His Arg 
    1355                 1360                 1365             


Gln Phe  Gly Arg Lys Pro Val  Val Gly Gln Cys Thr  Ile Glu Arg 
    1370                 1375                 1380             


Leu Asp  Arg Phe Arg Cys Asp  Pro Tyr Ala Gly Lys  Glu Asp Ile 
    1385                 1390                 1395             


Val Pro  Gln Leu Lys Ala Ser  Leu Leu Ser Ala Pro  Pro Cys Arg 
    1400                 1405                 1410             


Asp Ile  Val Ile Glu Met Glu  Asp Thr Lys Pro Leu  Leu Ala Ser 
    1415                 1420                 1425             


Lys Leu  Thr Glu Lys Glu Glu  Glu Ile Val Asp Trp  Trp Ser Lys 
    1430                 1435                 1440             


Phe Tyr  Ala Ser Ser Gly Glu  His Glu Lys Cys Gly  Gln Tyr Ile 
    1445                 1450                 1455             


Gln Lys  Gly Tyr Ser Lys Leu  Lys Ile Tyr Asn Cys  Glu Leu Glu 
    1460                 1465                 1470             


Asn Val  Ala Glu Phe Glu Gly  Leu Thr Asp Phe Ser  Asp Thr Phe 
    1475                 1480                 1485             


Lys Leu  Tyr Arg Gly Lys Ser  Asp Glu Asn Glu Asp  Pro Ser Val 
    1490                 1495                 1500             


Val Gly  Glu Phe Lys Gly Ser  Phe Arg Ile Tyr Pro  Leu Pro Asp 
    1505                 1510                 1515             


Asp Pro  Ser Val Pro Ala Pro  Pro Arg Gln Phe Arg  Glu Leu Pro 
    1520                 1525                 1530             


Asp Ser  Val Pro Gln Glu Cys  Thr Val Arg Ile Tyr  Ile Val Arg 
    1535                 1540                 1545             


Gly Leu  Glu Leu Gln Pro Gln  Asp Asn Asn Gly Leu  Cys Asp Pro 
    1550                 1555                 1560             


Tyr Ile  Lys Ile Thr Leu Gly  Lys Lys Val Ile Glu  Asp Arg Asp 
    1565                 1570                 1575             


His Tyr  Ile Pro Asn Thr Leu  Asn Pro Val Phe Gly  Arg Met Tyr 
    1580                 1585                 1590             


Glu Leu  Ser Cys Tyr Leu Pro  Gln Glu Lys Asp Leu  Lys Ile Ser 
    1595                 1600                 1605             


Val Tyr  Asp Tyr Asp Thr Phe  Thr Arg Asp Glu Lys  Val Gly Glu 
    1610                 1615                 1620             


Thr Ile  Ile Asp Leu Glu Asn  Arg Phe Leu Ser Arg  Phe Gly Ser 
    1625                 1630                 1635             


His Cys  Gly Ile Pro Glu Glu  Tyr Cys Val Ser Gly  Val Asn Thr 
    1640                 1645                 1650             


Trp Arg  Asp Gln Leu Arg Pro  Thr Gln Leu Leu Gln  Asn Val Ala 
    1655                 1660                 1665             


Arg Phe  Lys Gly Phe Pro Gln  Pro Ile Leu Ser Glu  Asp Gly Ser 
    1670                 1675                 1680             


Arg Ile  Arg Tyr Gly Gly Arg  Asp Tyr Ser Leu Asp  Glu Phe Glu 
    1685                 1690                 1695             


Ala Asn  Lys Ile Leu His Gln  His Leu Gly Ala Pro  Glu Glu Arg 
    1700                 1705                 1710             


Leu Ala  Leu His Ile Leu Arg  Thr Gln Gly Leu Val  Pro Glu His 
    1715                 1720                 1725             


Val Glu  Thr Arg Thr Leu His  Ser Thr Phe Gln Pro  Asn Ile Ser 
    1730                 1735                 1740             


Gln Gly  Lys Leu Gln Met Trp  Val Asp Val Phe Pro  Lys Ser Leu 
    1745                 1750                 1755             


Gly Pro  Pro Gly Pro Pro Phe  Asn Ile Thr Pro Arg  Lys Ala Lys 
    1760                 1765                 1770             


Lys Tyr  Tyr Leu Arg Val Ile  Ile Trp Asn Thr Lys  Asp Val Ile 
    1775                 1780                 1785             


Leu Asp  Glu Lys Ser Ile Thr  Gly Glu Glu Met Ser  Asp Ile Tyr 
    1790                 1795                 1800             


Val Lys  Gly Trp Ile Pro Gly  Asn Glu Glu Asn Lys  Gln Lys Thr 
    1805                 1810                 1815             


Asp Val  His Tyr Arg Ser Leu  Asp Gly Glu Gly Asn  Phe Asn Trp 
    1820                 1825                 1830             


Arg Phe  Val Phe Pro Phe Asp  Tyr Leu Pro Ala Glu  Gln Leu Cys 
    1835                 1840                 1845             


Ile Val  Ala Lys Lys Glu His  Phe Trp Ser Ile Asp  Gln Thr Glu 
    1850                 1855                 1860             


Phe Arg  Ile Pro Pro Arg Leu  Ile Ile Gln Ile Trp  Asp Asn Asp 
    1865                 1870                 1875             


Lys Phe  Ser Leu Asp Asp Tyr  Leu Gly Phe Leu Glu  Leu Asp Leu 
    1880                 1885                 1890             


Arg His  Thr Ile Ile Pro Ala  Lys Ser Pro Glu Lys  Cys Arg Leu 
    1895                 1900                 1905             


Asp Met  Ile Pro Asp Leu Lys  Ala Met Asn Pro Leu  Lys Ala Lys 
    1910                 1915                 1920             


Thr Ala  Ser Leu Phe Glu Gln  Lys Ser Met Lys Gly  Trp Trp Pro 
    1925                 1930                 1935             


Cys Tyr  Ala Glu Lys Asp Gly  Ala Arg Val Met Ala  Gly Lys Val 
    1940                 1945                 1950             


Glu Met  Thr Leu Glu Ile Leu  Asn Glu Lys Glu Ala  Asp Glu Arg 
    1955                 1960                 1965             


Pro Ala  Gly Lys Gly Arg Asp  Glu Pro Asn Met Asn  Pro Lys Leu 
    1970                 1975                 1980             


Asp Leu  Pro Asn Arg Pro Glu  Thr Ser Phe Leu Trp  Phe Thr Asn 
    1985                 1990                 1995             


Pro Cys  Lys Thr Met Lys Phe  Ile Val Trp Arg Arg  Phe Lys Trp 
    2000                 2005                 2010             


Val Ile  Ile Gly Leu Leu Phe  Leu Leu Ile Leu Leu  Leu Phe Val 
    2015                 2020                 2025             


Ala Val  Leu Leu Tyr Ser Leu  Pro Asn Tyr Leu Ser  Met Lys Ile 
    2030                 2035                 2040             


Val Lys  Pro Asn Val 
    2045             


<210>  5689
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  5689

Met Thr Thr Ala Ile Leu Glu Arg Leu Ser Thr Leu Ser Val Ser Gly 
1               5                   10                  15      


Gln Gln Leu Arg Arg Leu Pro Lys Ile Leu Glu Asp Gly Leu Pro Lys 
            20                  25                  30          


Met Pro Cys Thr Val Pro Glu Thr Asp Val Pro Gln Leu Phe Arg Glu 
        35                  40                  45              


Pro Tyr Ile Arg Thr Gly Tyr Arg Pro Thr Gly His Glu Trp Arg Tyr 
    50                  55                  60                  


Tyr Phe Phe Ser Leu Phe Gln Lys His Asn Glu Val Val Asn Val Trp 
65                  70                  75                  80  


Thr His Leu Leu Ala Ala Leu Ala Val Leu Leu Arg Phe Trp Ala Phe 
                85                  90                  95      


Ala Glu Ala Glu Ala Leu Pro Trp Ala Ser Thr His Ser Leu Pro Leu 
            100                 105                 110         


Leu Leu Phe Ile Leu Ser Ser Ile Thr Tyr Leu Thr Cys Ser Leu Leu 
        115                 120                 125             


Ala His Leu Leu Gln Ser Lys Ser Glu Leu Ser His Tyr Thr Phe Tyr 
    130                 135                 140                 


Phe Val Asp Tyr Val Gly Val Ser Val Tyr Gln Tyr Gly Ser Ala Leu 
145                 150                 155                 160 


Ala His Phe Phe Tyr Ser Ser Asp Gln Ala Trp Tyr Asp Arg Phe Trp 
                165                 170                 175     


Leu Phe Phe Leu Pro Ala Ala Ala Phe Cys Gly Trp Leu Ser Cys Ala 
            180                 185                 190         


Gly Cys Cys Tyr Ala Lys Tyr Arg Tyr Arg Arg Pro Tyr Pro Val Met 
        195                 200                 205             


Arg Lys Ile Cys Gln Val Val Pro Ala Gly Leu Ala Phe Ile Leu Asp 
    210                 215                 220                 


Ile Ser Pro Val Ala His Arg Val Ala Leu Cys His Leu Ala Gly Cys 
225                 230                 235                 240 


Gln Glu Gln Ala Ala Trp Tyr His Thr Leu Gln Ile Leu Phe Phe Leu 
                245                 250                 255     


Val Ser Ala Tyr Phe Phe Ser Cys Pro Val Pro Glu Lys Tyr Phe Pro 
            260                 265                 270         


Gly Ser Cys Asp Ile Val Gly His Gly His Gln Ile Phe His Ala Phe 
        275                 280                 285             


Leu Ser Ile Cys Thr Leu Ser Gln Leu Glu Ala Ile Leu Leu Asp Tyr 
    290                 295                 300                 


Gln Gly Arg Gln Glu Ile Phe Leu Gln Arg His Gly Pro Leu Ser Val 
305                 310                 315                 320 


His Met Ala Cys Leu Ser Phe Phe Phe Leu Ala Ala Cys Ser Ala Ala 
                325                 330                 335     


Thr Ala Ala Leu Leu Arg His Lys Val Lys Ala Arg Leu Thr Lys Lys 
            340                 345                 350         


Asp Ser 
        


<210>  5690
<211>  842
<212>  PRT
<213>  Homo sapiens

<400>  5690

Met Ala Val Arg Pro Gly Leu Trp Pro Ala Leu Leu Gly Ile Val Leu 
1               5                   10                  15      


Ala Ala Trp Leu Arg Gly Ser Gly Ala Gln Gln Ser Ala Thr Val Ala 
            20                  25                  30          


Asn Pro Val Pro Gly Ala Asn Pro Asp Leu Leu Pro His Phe Leu Val 
        35                  40                  45              


Glu Pro Glu Asp Val Tyr Ile Val Lys Asn Lys Pro Val Leu Leu Val 
    50                  55                  60                  


Cys Lys Ala Val Pro Ala Thr Gln Ile Phe Phe Lys Cys Asn Gly Glu 
65                  70                  75                  80  


Trp Val Arg Gln Val Asp His Val Ile Glu Arg Ser Thr Asp Gly Ser 
                85                  90                  95      


Ser Gly Leu Pro Thr Met Glu Val Arg Ile Asn Val Ser Arg Gln Gln 
            100                 105                 110         


Val Glu Lys Val Phe Gly Leu Glu Glu Tyr Trp Cys Gln Cys Val Ala 
        115                 120                 125             


Trp Ser Ser Ser Gly Thr Thr Lys Ser Gln Lys Ala Tyr Ile Arg Ile 
    130                 135                 140                 


Ala Tyr Leu Arg Lys Asn Phe Glu Gln Glu Pro Leu Ala Lys Glu Val 
145                 150                 155                 160 


Ser Leu Glu Gln Gly Ile Val Leu Pro Cys Arg Pro Pro Glu Gly Ile 
                165                 170                 175     


Pro Pro Ala Glu Val Glu Trp Leu Arg Asn Glu Asp Leu Val Asp Pro 
            180                 185                 190         


Ser Leu Asp Pro Asn Val Tyr Ile Thr Arg Glu His Ser Leu Val Val 
        195                 200                 205             


Arg Gln Ala Arg Leu Ala Asp Thr Ala Asn Tyr Thr Cys Val Ala Lys 
    210                 215                 220                 


Asn Ile Val Ala Arg Arg Arg Ser Ala Ser Ala Ala Val Ile Val Tyr 
225                 230                 235                 240 


Val Asp Gly Ser Trp Ser Pro Trp Ser Lys Trp Ser Ala Cys Gly Leu 
                245                 250                 255     


Asp Cys Thr His Trp Arg Ser Arg Glu Cys Ser Asp Pro Ala Pro Arg 
            260                 265                 270         


Asn Gly Gly Glu Glu Cys Gln Gly Thr Asp Leu Asp Thr Arg Asn Cys 
        275                 280                 285             


Thr Ser Asp Leu Cys Val His Thr Ala Ser Gly Pro Glu Asp Val Ala 
    290                 295                 300                 


Leu Tyr Val Gly Leu Ile Ala Val Ala Val Cys Leu Val Leu Leu Leu 
305                 310                 315                 320 


Leu Val Leu Ile Leu Val Tyr Cys Arg Lys Lys Glu Gly Leu Asp Ser 
                325                 330                 335     


Asp Val Ala Asp Ser Ser Ile Leu Thr Ser Gly Phe Gln Pro Val Ser 
            340                 345                 350         


Ile Lys Pro Ser Lys Ala Asp Asn Pro His Leu Leu Thr Ile Gln Pro 
        355                 360                 365             


Asp Leu Ser Thr Thr Thr Thr Thr Tyr Gln Gly Ser Leu Cys Pro Arg 
    370                 375                 380                 


Gln Asp Gly Pro Ser Pro Lys Phe Gln Leu Thr Asn Gly His Leu Leu 
385                 390                 395                 400 


Ser Pro Leu Gly Gly Gly Arg His Thr Leu His His Ser Ser Pro Thr 
                405                 410                 415     


Ser Glu Ala Glu Glu Phe Val Ser Arg Leu Ser Thr Gln Asn Tyr Phe 
            420                 425                 430         


Arg Ser Leu Pro Arg Gly Thr Ser Asn Met Thr Tyr Gly Thr Phe Asn 
        435                 440                 445             


Phe Leu Gly Gly Arg Leu Met Ile Pro Asn Thr Gly Ile Ser Leu Leu 
    450                 455                 460                 


Ile Pro Pro Asp Ala Ile Pro Arg Gly Lys Ile Tyr Glu Ile Tyr Leu 
465                 470                 475                 480 


Thr Leu His Lys Pro Glu Asp Val Arg Leu Pro Leu Ala Gly Cys Gln 
                485                 490                 495     


Thr Leu Leu Ser Pro Ile Val Ser Cys Gly Pro Pro Gly Val Leu Leu 
            500                 505                 510         


Thr Arg Pro Val Ile Leu Ala Met Asp His Cys Gly Glu Pro Ser Pro 
        515                 520                 525             


Asp Ser Trp Ser Leu Arg Leu Lys Lys Gln Ser Cys Glu Gly Ser Trp 
    530                 535                 540                 


Glu Asp Val Leu His Leu Gly Glu Glu Ala Pro Ser His Leu Tyr Tyr 
545                 550                 555                 560 


Cys Gln Leu Glu Ala Ser Ala Cys Tyr Val Phe Thr Glu Gln Leu Gly 
                565                 570                 575     


Arg Phe Ala Leu Val Gly Glu Ala Leu Ser Val Ala Ala Ala Lys Arg 
            580                 585                 590         


Leu Lys Leu Leu Leu Phe Ala Pro Val Ala Cys Thr Ser Leu Glu Tyr 
        595                 600                 605             


Asn Ile Arg Val Tyr Cys Leu His Asp Thr His Asp Ala Leu Lys Glu 
    610                 615                 620                 


Val Val Gln Leu Glu Lys Gln Leu Gly Gly Gln Leu Ile Gln Glu Pro 
625                 630                 635                 640 


Arg Val Leu His Phe Lys Asp Ser Tyr His Asn Leu Arg Leu Ser Ile 
                645                 650                 655     


His Asp Val Pro Ser Ser Leu Trp Lys Ser Lys Leu Leu Val Ser Tyr 
            660                 665                 670         


Gln Glu Ile Pro Phe Tyr His Ile Trp Asn Gly Thr Gln Arg Tyr Leu 
        675                 680                 685             


His Cys Thr Phe Thr Leu Glu Arg Val Ser Pro Ser Thr Ser Asp Leu 
    690                 695                 700                 


Ala Cys Lys Leu Trp Val Trp Gln Val Glu Gly Asp Gly Gln Ser Phe 
705                 710                 715                 720 


Ser Ile Asn Phe Asn Ile Thr Lys Asp Thr Arg Phe Ala Glu Leu Leu 
                725                 730                 735     


Ala Leu Glu Ser Glu Ala Gly Val Pro Ala Leu Val Gly Pro Ser Ala 
            740                 745                 750         


Phe Lys Ile Pro Phe Leu Ile Arg Gln Lys Ile Ile Ser Ser Leu Asp 
        755                 760                 765             


Pro Pro Cys Arg Arg Gly Ala Asp Trp Arg Thr Leu Ala Gln Lys Leu 
    770                 775                 780                 


His Leu Asp Ser His Leu Ser Phe Phe Ala Ser Lys Pro Ser Pro Thr 
785                 790                 795                 800 


Ala Met Ile Leu Asn Leu Trp Glu Ala Arg His Phe Pro Asn Gly Asn 
                805                 810                 815     


Leu Ser Gln Leu Ala Ala Ala Val Ala Gly Leu Gly Gln Pro Asp Ala 
            820                 825                 830         


Gly Leu Phe Thr Val Ser Glu Ala Glu Cys 
        835                 840         


<210>  5691
<211>  1115
<212>  PRT
<213>  Homo sapiens

<400>  5691

Met Arg Arg Leu Ser Leu Trp Trp Leu Leu Ser Arg Val Cys Leu Leu 
1               5                   10                  15      


Leu Pro Pro Pro Cys Ala Leu Val Leu Ala Gly Val Pro Ser Ser Ser 
            20                  25                  30          


Ser His Pro Gln Pro Cys Gln Ile Leu Lys Arg Ile Gly His Ala Val 
        35                  40                  45              


Arg Val Gly Ala Val His Leu Gln Pro Trp Thr Thr Ala Pro Arg Ala 
    50                  55                  60                  


Ala Ser Arg Ala Pro Asp Asp Ser Arg Ala Gly Ala Gln Arg Asp Glu 
65                  70                  75                  80  


Pro Glu Pro Gly Thr Arg Arg Ser Pro Ala Pro Ser Pro Gly Ala Arg 
                85                  90                  95      


Trp Leu Gly Ser Thr Leu His Gly Arg Gly Pro Pro Gly Ser Arg Lys 
            100                 105                 110         


Pro Gly Glu Gly Ala Arg Ala Glu Ala Leu Trp Pro Arg Asp Ala Leu 
        115                 120                 125             


Leu Phe Ala Val Asp Asn Leu Asn Arg Val Glu Gly Leu Leu Pro Tyr 
    130                 135                 140                 


Asn Leu Ser Leu Glu Val Val Met Ala Ile Glu Ala Gly Leu Gly Asp 
145                 150                 155                 160 


Leu Pro Leu Leu Pro Phe Ser Ser Pro Ser Ser Pro Trp Ser Ser Asp 
                165                 170                 175     


Pro Phe Ser Phe Leu Gln Ser Val Cys His Thr Val Val Val Gln Gly 
            180                 185                 190         


Val Ser Ala Leu Leu Ala Phe Pro Gln Ser Gln Gly Glu Met Met Glu 
        195                 200                 205             


Leu Asp Leu Val Ser Leu Val Leu His Ile Pro Val Ile Ser Ile Val 
    210                 215                 220                 


Arg His Glu Phe Pro Arg Glu Ser Gln Asn Pro Leu His Leu Gln Leu 
225                 230                 235                 240 


Ser Leu Glu Asn Ser Leu Ser Ser Asp Ala Asp Val Thr Val Ser Ile 
                245                 250                 255     


Leu Thr Met Asn Asn Trp Tyr Asn Phe Ser Leu Leu Leu Cys Gln Glu 
            260                 265                 270         


Asp Trp Asn Ile Thr Asp Phe Leu Leu Leu Thr Gln Asn Asn Ser Lys 
        275                 280                 285             


Phe His Leu Gly Ser Ile Ile Asn Ile Thr Ala Asn Leu Pro Ser Thr 
    290                 295                 300                 


Gln Asp Leu Leu Ser Phe Leu Gln Ile Gln Leu Glu Ser Ile Lys Asn 
305                 310                 315                 320 


Ser Thr Pro Thr Val Val Met Phe Gly Cys Asp Met Glu Ser Ile Arg 
                325                 330                 335     


Arg Ile Phe Glu Ile Thr Thr Gln Phe Gly Val Met Pro Pro Glu Leu 
            340                 345                 350         


Arg Trp Val Leu Gly Asp Ser Gln Asn Val Glu Glu Leu Arg Thr Glu 
        355                 360                 365             


Gly Leu Pro Leu Gly Leu Ile Ala His Gly Lys Thr Thr Gln Ser Val 
    370                 375                 380                 


Phe Glu His Tyr Val Gln Asp Ala Met Glu Leu Val Ala Arg Ala Val 
385                 390                 395                 400 


Ala Thr Ala Thr Met Ile Gln Pro Glu Leu Ala Leu Ile Pro Ser Thr 
                405                 410                 415     


Met Asn Cys Met Glu Val Glu Thr Thr Asn Leu Thr Ser Gly Gln Tyr 
            420                 425                 430         


Leu Ser Arg Phe Leu Ala Asn Thr Thr Phe Arg Gly Leu Ser Gly Ser 
        435                 440                 445             


Ile Arg Val Lys Gly Ser Thr Ile Val Ser Ser Glu Asn Asn Phe Phe 
    450                 455                 460                 


Ile Trp Asn Leu Gln His Asp Pro Met Gly Lys Pro Met Trp Thr Arg 
465                 470                 475                 480 


Leu Gly Ser Trp Gln Gly Gly Lys Ile Val Met Asp Tyr Gly Ile Trp 
                485                 490                 495     


Pro Glu Gln Ala Gln Arg His Lys Thr His Phe Gln His Pro Ser Lys 
            500                 505                 510         


Leu His Leu Arg Val Val Thr Leu Ile Glu His Pro Phe Val Phe Thr 
        515                 520                 525             


Arg Glu Val Asp Asp Glu Gly Leu Cys Pro Ala Gly Gln Leu Cys Leu 
    530                 535                 540                 


Asp Pro Met Thr Asn Asp Ser Ser Thr Leu Asp Ser Leu Phe Ser Ser 
545                 550                 555                 560 


Leu His Ser Ser Asn Asp Thr Val Pro Ile Lys Phe Lys Lys Cys Cys 
                565                 570                 575     


Tyr Gly Tyr Cys Ile Asp Leu Leu Glu Lys Ile Ala Glu Asp Met Asn 
            580                 585                 590         


Phe Asp Phe Asp Leu Tyr Ile Val Gly Asp Gly Lys Tyr Gly Ala Trp 
        595                 600                 605             


Lys Asn Gly His Trp Thr Gly Leu Val Gly Asp Leu Leu Arg Gly Thr 
    610                 615                 620                 


Ala His Met Ala Val Thr Ser Phe Ser Ile Asn Thr Ala Arg Ser Gln 
625                 630                 635                 640 


Val Ile Asp Phe Thr Ser Pro Phe Phe Ser Thr Ser Leu Gly Ile Leu 
                645                 650                 655     


Val Arg Thr Arg Asp Thr Ala Ala Pro Ile Gly Ala Phe Met Trp Pro 
            660                 665                 670         


Leu His Trp Thr Met Trp Leu Gly Ile Phe Val Ala Leu His Ile Thr 
        675                 680                 685             


Ala Val Phe Leu Thr Leu Tyr Glu Trp Lys Ser Pro Phe Gly Leu Thr 
    690                 695                 700                 


Pro Lys Gly Arg Asn Arg Ser Lys Val Phe Ser Phe Ser Ser Ala Leu 
705                 710                 715                 720 


Asn Ile Cys Tyr Ala Leu Leu Phe Gly Arg Thr Val Ala Ile Lys Pro 
                725                 730                 735     


Pro Lys Cys Trp Thr Gly Arg Phe Leu Met Asn Leu Trp Ala Ile Phe 
            740                 745                 750         


Cys Met Phe Cys Leu Ser Thr Tyr Thr Ala Asn Leu Ala Ala Val Met 
        755                 760                 765             


Val Gly Glu Lys Ile Tyr Glu Glu Leu Ser Gly Ile His Asp Pro Lys 
    770                 775                 780                 


Leu His His Pro Ser Gln Gly Phe Arg Phe Gly Thr Val Arg Glu Ser 
785                 790                 795                 800 


Ser Ala Glu Asp Tyr Val Arg Gln Ser Phe Pro Glu Met His Glu Tyr 
                805                 810                 815     


Met Arg Arg Tyr Asn Val Pro Ala Thr Pro Asp Gly Val Glu Tyr Leu 
            820                 825                 830         


Lys Asn Asp Pro Glu Lys Leu Asp Ala Phe Ile Met Asp Lys Ala Leu 
        835                 840                 845             


Leu Asp Tyr Glu Val Ser Ile Asp Ala Asp Cys Lys Leu Leu Thr Val 
    850                 855                 860                 


Gly Lys Pro Phe Ala Ile Glu Gly Tyr Gly Ile Gly Leu Pro Pro Asn 
865                 870                 875                 880 


Ser Pro Leu Thr Ala Asn Ile Ser Glu Leu Ile Ser Gln Tyr Lys Ser 
                885                 890                 895     


His Gly Phe Met Asp Met Leu His Asp Lys Trp Tyr Arg Val Val Pro 
            900                 905                 910         


Cys Gly Lys Arg Ser Phe Ala Val Thr Glu Thr Leu Gln Met Gly Ile 
        915                 920                 925             


Lys His Phe Ser Gly Leu Phe Val Leu Leu Cys Ile Gly Phe Gly Leu 
    930                 935                 940                 


Ser Ile Leu Thr Thr Ile Gly Glu His Ile Val Tyr Arg Leu Leu Leu 
945                 950                 955                 960 


Pro Arg Ile Lys Asn Lys Ser Lys Leu Gln Tyr Trp Leu His Thr Ser 
                965                 970                 975     


Gln Arg Leu His Arg Ala Ile Asn Thr Ser Phe Ile Glu Glu Lys Gln 
            980                 985                 990         


Gln His Phe Lys Thr Lys Arg Val  Glu Lys Arg Ser Asn  Val Gly Pro 
        995                 1000                 1005             


Arg Gln  Leu Thr Val Trp Asn  Thr Ser Asn Leu Ser  His Asp Asn 
    1010                 1015                 1020             


Arg Arg  Lys Tyr Ile Phe Ser  Asp Glu Glu Gly Gln  Asn Gln Leu 
    1025                 1030                 1035             


Gly Ile  Arg Ile His Gln Asp  Ile Pro Leu Pro Pro  Arg Arg Arg 
    1040                 1045                 1050             


Glu Leu  Pro Ala Leu Arg Thr  Thr Asn Gly Lys Ala  Asp Ser Leu 
    1055                 1060                 1065             


Asn Val  Ser Arg Asn Ser Val  Met Gln Glu Leu Ser  Glu Leu Glu 
    1070                 1075                 1080             


Lys Gln  Ile Gln Val Ile Arg  Gln Glu Leu Gln Leu  Ala Val Ser 
    1085                 1090                 1095             


Arg Lys  Thr Glu Leu Glu Glu  Tyr Gln Arg Thr Ser  Arg Thr Cys 
    1100                 1105                 1110             


Glu Ser  
    1115 


<210>  5692
<211>  1099
<212>  PRT
<213>  Homo sapiens

<400>  5692

Met Cys Pro Ser Glu Met Gly Thr Leu Trp His His Trp Ser Pro Val 
1               5                   10                  15      


Leu Ile Ser Leu Ala Ala Leu Phe Ser Lys Val Thr Glu Gly Arg Gly 
            20                  25                  30          


Ile Leu Glu Ser Ile Gln Arg Phe Ser Leu Leu Pro Thr Tyr Leu Pro 
        35                  40                  45              


Val Thr Tyr His Ile Asn Asn Ala Asp Val Ser Phe Phe Leu Lys Glu 
    50                  55                  60                  


Ala Asn Gln Asp Ile Met Arg Asn Ser Ser Leu Gln Ser Arg Val Glu 
65                  70                  75                  80  


Ser Phe Leu Ile Tyr Lys Ser Arg Arg Leu Pro Val Leu Asn Ala Ser 
                85                  90                  95      


Tyr Gly Pro Phe Ser Ile Glu Gln Val Val Pro Gln Asp Leu Met Leu 
            100                 105                 110         


Pro Ser Asn Pro Phe Gly Phe Thr Asn Lys Phe Ser Leu Asn Trp Lys 
        115                 120                 125             


Leu Lys Ala His Ile Leu Arg Asp Lys Val Tyr Leu Ser Arg Pro Lys 
    130                 135                 140                 


Val Gln Val Leu Phe His Ile Met Gly Arg Asp Trp Asp Asp Arg Ser 
145                 150                 155                 160 


Ala Gly Glu Lys Leu Pro Cys Leu Arg Val Phe Ala Phe Arg Glu Thr 
                165                 170                 175     


Arg Glu Val Arg Gly Ser Cys Arg Leu Gln Gly Asp Leu Gly Leu Cys 
            180                 185                 190         


Val Ala Glu Leu Glu Leu Leu Ser Ser Trp Phe Ser Pro Pro Thr Val 
        195                 200                 205             


Val Ala Gly Arg Arg Lys Ser Val Asp Gln Pro Glu Gly Thr Pro Val 
    210                 215                 220                 


Glu Leu Tyr Tyr Thr Val His Pro Gly Gly Glu Arg Gly Asp Cys Val 
225                 230                 235                 240 


Arg Glu Asp Ala Arg Arg Ser Asn Gly Ile Arg Thr Gly His Ser Asp 
                245                 250                 255     


Ile Asp Glu Ser Gly Pro Pro Leu Gln Arg Ile Gly Ser Ile Phe Leu 
            260                 265                 270         


Tyr Gln Thr His Arg Lys Pro Ser Leu Arg Glu Leu Arg Leu Asp Asn 
        275                 280                 285             


Ser Val Ala Ile His Tyr Ile Pro Lys Thr Val Arg Lys Gly Asp Val 
    290                 295                 300                 


Leu Thr Phe Pro Val Ser Ile Ser Arg Asn Ser Thr Glu Asp Arg Phe 
305                 310                 315                 320 


Thr Leu Arg Ala Lys Val Lys Lys Gly Val Asn Ile Ile Gly Val Arg 
                325                 330                 335     


Ala Ser Ser Pro Ser Ile Trp Asp Val Lys Glu Arg Thr Asp Tyr Thr 
            340                 345                 350         


Gly Lys Tyr Ala Pro Ala Val Ile Val Cys Gln Lys Lys Ala Ala Gly 
        355                 360                 365             


Ser Glu Asn Ser Ala Asp Gly Ala Ser Tyr Glu Val Met Gln Ile Asp 
    370                 375                 380                 


Val Glu Val Glu Glu Pro Gly Asp Leu Pro Ala Thr Gln Leu Val Thr 
385                 390                 395                 400 


Trp Gln Val Glu Tyr Pro Gly Glu Ile Thr Ser Asp Leu Gly Val Ser 
                405                 410                 415     


Lys Ile Tyr Val Ser Pro Lys Asp Leu Ile Gly Val Val Pro Leu Ala 
            420                 425                 430         


Met Glu Ala Glu Ile Leu Asn Thr Ala Ile Leu Thr Gly Lys Thr Val 
        435                 440                 445             


Ala Val Pro Val Lys Val Val Ser Val Glu Asp Asp Gly Thr Val Thr 
    450                 455                 460                 


Glu Leu Leu Glu Ser Val Glu Cys Arg Ser Ser Asp Glu Asp Val Ile 
465                 470                 475                 480 


Lys Val Ser Asp Arg Cys Asp Tyr Val Phe Val Asn Gly Lys Glu Met 
                485                 490                 495     


Lys Gly Lys Val Asn Val Val Val Asn Phe Thr Tyr Gln His Leu Ser 
            500                 505                 510         


Ser Pro Leu Glu Met Thr Val Trp Val Pro Arg Leu Pro Leu Gln Ile 
        515                 520                 525             


Glu Val Ser Asp Thr Glu Leu Asn Gln Ile Lys Gly Trp Arg Val Pro 
    530                 535                 540                 


Ile Val Ser Ser Arg Arg Pro Ala Gly Asp Ser Glu Glu Glu Glu Asp 
545                 550                 555                 560 


Asp Glu Arg Arg Gly Arg Gly Cys Thr Leu Gln Tyr Gln His Ala Met 
                565                 570                 575     


Val Arg Val Leu Thr Gln Phe Val Ala Glu Ala Ala Gly Pro Gly Gly 
            580                 585                 590         


His Leu Ala His Leu Leu Gly Ser Asp Trp Gln Val Asp Ile Thr Glu 
        595                 600                 605             


Leu Ile Asn Asp Phe Met Gln Val Glu Glu Pro Arg Ile Ala Lys Leu 
    610                 615                 620                 


Gln Gly Gly Gln Ile Leu Met Gly Gln Glu Leu Gly Met Thr Thr Ile 
625                 630                 635                 640 


Gln Ile Leu Ser Pro Leu Ser Asp Thr Ile Leu Ala Glu Lys Thr Ile 
                645                 650                 655     


Thr Val Leu Asp Glu Lys Val Thr Ile Thr Asp Leu Gly Val Gln Leu 
            660                 665                 670         


Val Thr Gly Leu Ser Leu Ser Leu Gln Leu Ser Pro Gly Ser Asn Arg 
        675                 680                 685             


Ala Ile Phe Ala Thr Ala Val Ala Gln Glu Leu Leu Gln Arg Pro Lys 
    690                 695                 700                 


Gln Glu Ala Ala Ile Ser Cys Trp Val Gln Phe Ser Asp Gly Ser Val 
705                 710                 715                 720 


Thr Pro Leu Asp Ile Tyr Asp Gly Lys Asp Phe Ser Leu Met Ala Thr 
                725                 730                 735     


Ser Leu Asp Glu Lys Val Val Ser Ile His Gln Asp Pro Lys Phe Lys 
            740                 745                 750         


Trp Pro Ile Ile Ala Ala Glu Thr Glu Gly Gln Gly Thr Leu Val Lys 
        755                 760                 765             


Val Glu Met Val Ile Ser Glu Ser Cys Gln Lys Ser Lys Arg Lys Ser 
    770                 775                 780                 


Val Leu Ala Val Gly Thr Ala Asn Ile Lys Val Lys Phe Gly Gln Asn 
785                 790                 795                 800 


Asp Ala Asn Pro Asn Thr Ser Asp Ser Arg His Thr Gly Ala Gly Val 
                805                 810                 815     


His Met Glu Asn Asn Val Ser Asp Arg Arg Pro Lys Lys Pro Ser Gln 
            820                 825                 830         


Glu Trp Gly Ser Gln Glu Gly Gln Tyr Tyr Gly Ser Ser Ser Met Gly 
        835                 840                 845             


Leu Met Glu Gly Arg Gly Thr Thr Thr Asp Arg Ser Ile Leu Gln Lys 
    850                 855                 860                 


Lys Lys Gly Gln Glu Ser Leu Leu Asp Asp Asn Ser His Leu Gln Thr 
865                 870                 875                 880 


Ile Pro Ser Asp Leu Thr Ser Phe Pro Ala Gln Val Asp Leu Pro Arg 
                885                 890                 895     


Ser Asn Gly Glu Met Asp Gly Asn Asp Leu Met Gln Ala Ser Lys Gly 
            900                 905                 910         


Leu Ser Asp Leu Glu Ile Gly Met Tyr Ala Leu Leu Gly Val Phe Cys 
        915                 920                 925             


Leu Ala Ile Leu Val Phe Leu Ile Asn Cys Val Thr Phe Ala Leu Lys 
    930                 935                 940                 


Tyr Arg His Lys Gln Val Pro Phe Glu Glu Gln Glu Gly Met Ser His 
945                 950                 955                 960 


Ser His Asp Trp Val Gly Leu Ser Asn Arg Thr Glu Leu Leu Glu Asn 
                965                 970                 975     


His Ile Asn Phe Ala Ser Ser Gln Asp Glu Gln Ile Thr Ala Ile Asp 
            980                 985                 990         


Arg Gly Met Asp Phe Glu Glu Ser  Lys Tyr Leu Leu Ser  Thr Asn Ser 
        995                 1000                 1005             


Gln Lys  Ser Ile Asn Gly Gln  Leu Phe Lys Pro Leu  Gly Pro Ile 
    1010                 1015                 1020             


Ile Ile  Asp Gly Lys Asp Gln  Lys Ser Glu Pro Pro  Thr Ser Pro 
    1025                 1030                 1035             


Thr Ser  Lys Arg Lys Arg Val  Lys Phe Thr Thr Phe  Thr Ala Val 
    1040                 1045                 1050             


Ser Ser  Asp Asp Glu Tyr Pro  Thr Arg Asn Ser Ile  Val Met Ser 
    1055                 1060                 1065             


Ser Glu  Asp Asp Ile Lys Trp  Val Cys Gln Asp Leu  Asp Pro Gly 
    1070                 1075                 1080             


Asp Cys  Lys Glu Leu His Asn  Tyr Met Glu Arg Leu  His Glu Asn 
    1085                 1090                 1095             


Val 
    


<210>  5693
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  5693

Met Gly Gly Pro Arg Ala Trp Ala Leu Leu Cys Leu Gly Leu Leu Leu 
1               5                   10                  15      


Pro Gly Gly Gly Ala Ala Trp Ser Ile Gly Ala Ala Pro Phe Ser Gly 
            20                  25                  30          


Arg Arg Asn Trp Cys Ser Tyr Val Val Thr Arg Thr Ile Ser Cys His 
        35                  40                  45              


Val Gln Asn Gly Thr Tyr Leu Gln Arg Val Leu Gln Asn Cys Pro Trp 
    50                  55                  60                  


Pro Met Ser Cys Pro Gly Ser Ser Tyr Arg Thr Val Val Arg Pro Thr 
65                  70                  75                  80  


Tyr Lys Val Met Tyr Lys Ile Val Thr Ala Arg Glu Trp Arg Cys Cys 
                85                  90                  95      


Pro Gly His Ser Gly Val Ser Cys Glu Glu Val Ala Ala Ser Ser Ala 
            100                 105                 110         


Ser Leu Glu Pro Met Trp Ser Gly Ser Thr Met Arg Arg Met Ala Leu 
        115                 120                 125             


Arg Pro Thr Ala Phe Ser Gly Cys Leu Asn Cys Ser Lys Val Ser Glu 
    130                 135                 140                 


Leu Thr Glu Arg Leu Lys Val Leu Glu Ala Lys Met Thr Met Leu Thr 
145                 150                 155                 160 


Val Ile Glu Gln Pro Val Pro Pro Thr Pro Ala Thr Pro Glu Asp Pro 
                165                 170                 175     


Ala Pro Leu Trp Gly Pro Pro Pro Ala Gln Gly Ser Pro Gly Asp Gly 
            180                 185                 190         


Gly Leu Gln Asp Gln Val Gly Ala Trp Gly Leu Pro Gly Pro Thr Gly 
        195                 200                 205             


Pro Lys Gly Asp Ala Gly Ser Arg Gly Pro Met Gly Met Arg Gly Pro 
    210                 215                 220                 


Pro Gly Pro Gln Gly Pro Pro Gly Ser Pro Gly Arg Ala Gly Ala Val 
225                 230                 235                 240 


Gly Thr Pro Gly Glu Arg Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
                245                 250                 255     


Pro Pro Gly Pro Pro Ala Pro Val Gly Pro Pro His Ala Arg Ile Ser 
            260                 265                 270         


Gln His Gly Asp Pro Leu Leu Ser Asn Thr Phe Thr Glu Thr Asn Asn 
        275                 280                 285             


His Trp Pro Gln Gly Pro Thr Gly Pro Pro Gly Pro Pro Gly Pro Met 
    290                 295                 300                 


Gly Pro Pro Gly Pro Pro Gly Pro Thr Gly Val Pro Gly Ser Pro Gly 
305                 310                 315                 320 


His Ile Gly Pro Pro Gly Pro Thr Gly Pro Lys Gly Ile Ser Gly His 
                325                 330                 335     


Pro Gly Glu Lys Gly Glu Arg Gly Leu Arg Gly Glu Pro Gly Pro Gln 
            340                 345                 350         


Gly Ser Ala Gly Gln Arg Gly Glu Pro Gly Pro Lys Gly Asp Pro Gly 
        355                 360                 365             


Glu Lys Ser His Trp Gly Glu Gly Leu His Gln Leu Arg Glu Ala Leu 
    370                 375                 380                 


Lys Ile Leu Ala Glu Arg Val Leu Ile Leu Glu Thr Met Ile Gly Leu 
385                 390                 395                 400 


Tyr Glu Pro Glu Leu Gly Ser Gly Ala Gly Pro Ala Gly Thr Gly Thr 
                405                 410                 415     


Pro Ser Leu Leu Arg Gly Lys Arg Gly Gly His Ala Thr Asn Tyr Arg 
            420                 425                 430         


Ile Val Ala Pro Arg Ser Arg Asp Glu Arg Gly 
        435                 440             


<210>  5694
<211>  439
<212>  PRT
<213>  Homo sapiens

<400>  5694

Met Lys Leu Ala Leu Leu Leu Pro Trp Ala Cys Cys Cys Leu Cys Gly 
1               5                   10                  15      


Ser Ala Leu Ala Thr Gly Phe Leu Tyr Pro Phe Ser Ala Ala Ala Leu 
            20                  25                  30          


Gln Gln His Gly Tyr Pro Glu Pro Gly Ala Gly Ser Pro Gly Ser Gly 
        35                  40                  45              


Tyr Ala Ser Arg Arg His Trp Cys His His Thr Val Thr Arg Thr Val 
    50                  55                  60                  


Ser Cys Gln Val Gln Asn Gly Ser Glu Thr Val Val Gln Arg Val Tyr 
65                  70                  75                  80  


Gln Ser Cys Arg Trp Pro Gly Pro Cys Ala Asn Leu Val Arg Thr Leu 
                85                  90                  95      


Ile Arg Pro Thr Tyr Arg Val Ser Tyr Arg Thr Val Thr Val Leu Glu 
            100                 105                 110         


Trp Arg Cys Cys Pro Gly Phe Thr Gly Ser Asn Cys Asp Glu Glu Cys 
        115                 120                 125             


Met Asn Cys Thr Arg Leu Ser Asp Met Ser Glu Arg Leu Thr Thr Leu 
    130                 135                 140                 


Glu Ala Lys Val Leu Leu Leu Glu Ala Ala Glu Arg Pro Ser Ser Pro 
145                 150                 155                 160 


Asp Asn Asp Leu Pro Ala Pro Glu Ser Thr Pro Pro Thr Trp Asn Glu 
                165                 170                 175     


Asp Phe Leu Pro Asp Ala Ile Pro Leu Ala His Pro Val Pro Arg Gln 
            180                 185                 190         


Arg Arg Pro Thr Gly Pro Ala Gly Pro Pro Gly Gln Thr Gly Pro Pro 
        195                 200                 205             


Gly Pro Ala Gly Pro Pro Gly Ser Lys Gly Asp Arg Gly Gln Thr Gly 
    210                 215                 220                 


Glu Lys Gly Pro Ala Gly Pro Pro Gly Leu Leu Gly Pro Pro Gly Pro 
225                 230                 235                 240 


Arg Gly Leu Pro Gly Glu Met Gly Arg Pro Gly Pro Pro Gly Pro Pro 
                245                 250                 255     


Gly Pro Ala Gly Asn Pro Gly Pro Ser Pro Asn Ser Pro Gln Gly Ala 
            260                 265                 270         


Leu Tyr Ser Leu Gln Pro Pro Thr Asp Lys Asp Asn Gly Asp Ser Arg 
        275                 280                 285             


Leu Ala Ser Ala Ile Val Asp Thr Val Leu Ala Gly Val Pro Gly Pro 
    290                 295                 300                 


Arg Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Pro Pro 
305                 310                 315                 320 


Gly Pro Pro Gly Thr Pro Gly Ser Gln Gly Leu Ala Gly Glu Arg Gly 
                325                 330                 335     


Thr Val Gly Pro Ser Gly Glu Pro Gly Val Lys Gly Glu Glu Gly Glu 
            340                 345                 350         


Lys Ala Ala Thr Ala Glu Gly Glu Gly Val Gln Gln Leu Arg Glu Ala 
        355                 360                 365             


Leu Lys Ile Leu Ala Glu Arg Val Leu Ile Leu Glu His Met Ile Gly 
    370                 375                 380                 


Ile His Asp Pro Leu Ala Ser Pro Glu Gly Gly Ser Gly Gln Asp Ala 
385                 390                 395                 400 


Ala Leu Arg Ala Asn Leu Lys Met Lys Arg Gly Gly Ala Gln Pro Asp 
                405                 410                 415     


Gly Val Leu Ala Ala Leu Leu Gly Pro Asp Pro Gly Gln Lys Ser Val 
            420                 425                 430         


Asp Gln Ala Ser Ser Arg Lys 
        435                 


<210>  5695
<211>  1121
<212>  PRT
<213>  Homo sapiens

<400>  5695

Met Lys Val Lys Glu Glu Lys Ala Gly Val Gly Lys Leu Asp His Thr 
1               5                   10                  15      


Asn His Arg Arg Arg Phe Pro Asp Gln Lys Glu Cys Pro Pro Ile His 
            20                  25                  30          


Ile Gly Leu Pro Val Pro Thr Tyr Pro Gln Arg Lys Thr Asp Gln Lys 
        35                  40                  45              


Gly His Leu Ser Gly Leu Gln Lys Val His Trp Gly Leu Arg Pro Asp 
    50                  55                  60                  


Gln Pro Gln Gln Glu Leu Thr Gly Pro Gly Ser Gly Ala Ser Ser Gln 
65                  70                  75                  80  


Asp Ser Ser Met Asp Leu Ile Ser Arg Thr Arg Ser Pro Ala Ala Glu 
                85                  90                  95      


Gln Leu Gln Asp Ile Leu Gly Glu Glu Asp Glu Ala Pro Asn Pro Thr 
            100                 105                 110         


Leu Phe Thr Glu Met Asp Thr Leu Gln His Asp Gly Asp Gln Met Glu 
        115                 120                 125             


Trp Lys Glu Ser Ala Arg Trp Ile Lys Phe Glu Glu Lys Val Glu Glu 
    130                 135                 140                 


Gly Gly Glu Arg Trp Ser Lys Pro His Val Ser Thr Leu Ser Leu His 
145                 150                 155                 160 


Ser Leu Phe Glu Leu Arg Thr Cys Leu Gln Thr Gly Thr Val Leu Leu 
                165                 170                 175     


Asp Leu Asp Ser Gly Ser Leu Pro Gln Ile Ile Asp Asp Val Ile Glu 
            180                 185                 190         


Lys Gln Ile Glu Asp Gly Leu Leu Arg Pro Glu Leu Arg Glu Arg Val 
        195                 200                 205             


Ser Tyr Val Leu Leu Arg Arg His Arg His Gln Thr Lys Lys Pro Ile 
    210                 215                 220                 


His Arg Ser Leu Ala Asp Ile Gly Lys Ser Val Ser Thr Thr Asn Arg 
225                 230                 235                 240 


Ser Pro Ala Arg Ser Pro Gly Ala Gly Pro Ser Leu His His Ser Thr 
                245                 250                 255     


Glu Asp Leu Arg Met Arg Gln Ser Ala Asn Tyr Gly Arg Leu Cys His 
            260                 265                 270         


Ala Gln Ser Arg Ser Met Asn Asp Ile Ser Leu Thr Pro Asn Thr Asp 
        275                 280                 285             


Gln Arg Lys Asn Lys Phe Met Lys Lys Ile Pro Lys Asp Ser Glu Ala 
    290                 295                 300                 


Ser Asn Val Leu Val Gly Glu Val Asp Phe Leu Asp Gln Pro Phe Ile 
305                 310                 315                 320 


Ala Phe Val Arg Leu Ile Gln Ser Ala Met Leu Gly Gly Val Thr Glu 
                325                 330                 335     


Val Pro Val Pro Thr Arg Phe Leu Phe Ile Leu Leu Gly Pro Ser Gly 
            340                 345                 350         


Arg Ala Lys Ser Tyr Asn Glu Ile Gly Arg Ala Ile Ala Thr Leu Met 
        355                 360                 365             


Val Asp Asp Leu Phe Ser Asp Val Ala Tyr Lys Ala Arg Asn Arg Glu 
    370                 375                 380                 


Asp Leu Ile Ala Gly Ile Asp Glu Phe Leu Asp Glu Val Ile Val Leu 
385                 390                 395                 400 


Pro Pro Gly Glu Trp Asp Pro Asn Ile Arg Ile Glu Pro Pro Lys Lys 
                405                 410                 415     


Val Pro Ser Ala Asp Lys Arg Lys Ser Val Phe Ser Leu Ala Glu Leu 
            420                 425                 430         


Gly Gln Met Asn Gly Ser Val Gly Gly Gly Gly Gly Ala Pro Gly Gly 
        435                 440                 445             


Gly Asn Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Ala Gly Ser 
    450                 455                 460                 


Gly Gly Ala Gly Gly Thr Ser Ser Gly Asp Asp Gly Glu Met Pro Ala 
465                 470                 475                 480 


Met His Glu Ile Gly Glu Glu Leu Ile Trp Thr Gly Arg Phe Phe Gly 
                485                 490                 495     


Gly Leu Cys Leu Asp Ile Lys Arg Lys Leu Pro Trp Phe Pro Ser Asp 
            500                 505                 510         


Phe Tyr Asp Gly Phe His Ile Gln Ser Ile Ser Ala Ile Leu Phe Ile 
        515                 520                 525             


Tyr Leu Gly Cys Ile Thr Asn Ala Ile Thr Phe Gly Gly Leu Leu Gly 
    530                 535                 540                 


Asp Ala Thr Asp Asn Tyr Gln Gly Val Met Glu Ser Phe Leu Gly Thr 
545                 550                 555                 560 


Ala Met Ala Gly Ser Leu Phe Cys Leu Phe Ser Gly Gln Pro Leu Ile 
                565                 570                 575     


Ile Leu Ser Ser Thr Gly Pro Ile Leu Ile Phe Glu Lys Leu Leu Phe 
            580                 585                 590         


Asp Phe Ser Lys Gly Asn Gly Leu Asp Tyr Met Glu Phe Arg Leu Trp 
        595                 600                 605             


Ile Gly Leu His Ser Ala Val Gln Cys Leu Ile Leu Val Ala Thr Asp 
    610                 615                 620                 


Ala Ser Phe Ile Ile Lys Tyr Ile Thr Arg Phe Thr Glu Glu Gly Phe 
625                 630                 635                 640 


Ser Thr Leu Ile Ser Phe Ile Phe Ile Tyr Asp Ala Ile Lys Lys Met 
                645                 650                 655     


Ile Gly Ala Phe Lys Tyr Tyr Pro Ile Asn Met Asp Phe Lys Pro Asn 
            660                 665                 670         


Phe Ile Thr Thr Tyr Lys Cys Glu Cys Val Ala Pro Asp Thr Val Asn 
        675                 680                 685             


Thr Thr Val Phe Asn Ala Ser Ala Pro Leu Ala Pro Asp Thr Asn Ala 
    690                 695                 700                 


Ser Leu Tyr Asn Leu Leu Asn Leu Thr Ala Leu Asp Trp Ser Leu Leu 
705                 710                 715                 720 


Ser Lys Lys Glu Cys Leu Ser Tyr Gly Gly Arg Leu Leu Gly Asn Ser 
                725                 730                 735     


Cys Lys Phe Ile Pro Asp Leu Ala Leu Met Ser Phe Ile Leu Phe Phe 
            740                 745                 750         


Gly Thr Tyr Ser Met Thr Leu Thr Leu Lys Lys Phe Lys Phe Ser Arg 
        755                 760                 765             


Tyr Phe Pro Thr Lys Val Arg Ala Leu Val Ala Asp Phe Ser Ile Val 
    770                 775                 780                 


Phe Ser Ile Leu Met Phe Cys Gly Ile Asp Ala Cys Phe Gly Leu Glu 
785                 790                 795                 800 


Thr Pro Lys Leu His Val Pro Ser Val Ile Lys Pro Thr Arg Pro Asp 
                805                 810                 815     


Arg Gly Trp Phe Val Ala Pro Phe Gly Lys Asn Pro Trp Trp Val Tyr 
            820                 825                 830         


Pro Ala Ser Ile Leu Pro Ala Leu Leu Val Thr Ile Leu Ile Phe Met 
        835                 840                 845             


Asp Gln Gln Ile Thr Ala Val Ile Val Asn Arg Lys Glu Asn Lys Leu 
    850                 855                 860                 


Lys Lys Ala Ala Gly Tyr His Leu Asp Leu Phe Trp Val Gly Ile Leu 
865                 870                 875                 880 


Met Ala Leu Cys Ser Phe Met Gly Leu Pro Trp Tyr Val Ala Ala Thr 
                885                 890                 895     


Val Ile Ser Ile Ala His Ile Asp Ser Leu Lys Met Glu Thr Glu Thr 
            900                 905                 910         


Ser Ala Pro Gly Glu Gln Pro Gln Phe Leu Gly Val Arg Glu Gln Arg 
        915                 920                 925             


Val Thr Gly Ile Ile Val Phe Ile Leu Thr Gly Ile Ser Val Phe Leu 
    930                 935                 940                 


Ala Pro Ile Leu Lys Cys Ile Pro Leu Pro Val Leu Tyr Gly Val Phe 
945                 950                 955                 960 


Leu Tyr Met Gly Val Ala Ser Leu Asn Gly Ile Gln Phe Trp Glu Arg 
                965                 970                 975     


Cys Lys Leu Phe Leu Met Pro Ala Lys His Gln Pro Asp His Ala Phe 
            980                 985                 990         


Leu Arg His Val Pro Leu Arg Arg  Ile His Leu Phe Thr  Leu Val Gln 
        995                 1000                 1005             


Ile Leu  Cys Leu Ala Val Leu  Trp Ile Leu Lys Ser  Thr Val Ala 
    1010                 1015                 1020             


Ala Ile  Ile Phe Pro Val Met  Ile Leu Gly Leu Ile  Ile Val Arg 
    1025                 1030                 1035             


Arg Leu  Leu Asp Phe Ile Phe  Ser Gln His Asp Leu  Ala Trp Ile 
    1040                 1045                 1050             


Asp Asn  Ile Leu Pro Glu Lys  Glu Lys Lys Glu Thr  Asp Lys Lys 
    1055                 1060                 1065             


Arg Lys  Arg Lys Lys Gly Ala  His Glu Asp Cys Asp  Glu Glu Pro 
    1070                 1075                 1080             


Gln Phe  Pro Pro Pro Ser Val  Ile Lys Ile Pro Met  Glu Ser Val 
    1085                 1090                 1095             


Gln Ser  Asp Pro Gln Asn Gly  Ile His Cys Ile Ala  Arg Lys Arg 
    1100                 1105                 1110             


Ser Ser  Ser Trp Ser Tyr Ser  Leu 
    1115                 1120     


<210>  5696
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  5696

Met Pro Ser Ile Phe Ala Tyr Gln Ser Ser Glu Val Asp Trp Cys Glu 
1               5                   10                  15      


Ser Asn Phe Gln Tyr Ser Glu Leu Val Ala Glu Phe Tyr Asn Thr Phe 
            20                  25                  30          


Ser Asn Ile Pro Phe Phe Ile Phe Gly Pro Leu Met Met Leu Leu Met 
        35                  40                  45              


His Pro Tyr Ala Gln Lys Arg Ser Arg Tyr Ile Tyr Val Val Trp Val 
    50                  55                  60                  


Leu Phe Met Ile Ile Gly Leu Phe Ser Met Tyr Phe His Met Thr Leu 
65                  70                  75                  80  


Ser Phe Leu Gly Gln Leu Leu Asp Glu Ile Ala Ile Leu Trp Leu Leu 
                85                  90                  95      


Gly Ser Gly Tyr Ser Ile Trp Met Pro Arg Cys Tyr Phe Pro Ser Phe 
            100                 105                 110         


Leu Gly Gly Asn Arg Ser Gln Phe Ile Arg Leu Val Phe Ile Thr Thr 
        115                 120                 125             


Val Val Ser Thr Leu Leu Ser Phe Leu Arg Pro Thr Val Asn Ala Tyr 
    130                 135                 140                 


Ala Leu Asn Ser Ile Ala Leu His Ile Leu Tyr Ile Val Cys Gln Glu 
145                 150                 155                 160 


Tyr Arg Lys Thr Ser Asn Lys Glu Leu Arg His Leu Ile Glu Val Ser 
                165                 170                 175     


Val Val Leu Trp Ala Val Ala Leu Thr Ser Trp Ile Ser Asp Arg Leu 
            180                 185                 190         


Leu Cys Ser Phe Trp Gln Arg Ile His Phe Phe Tyr Leu His Ser Ile 
        195                 200                 205             


Trp His Val Leu Ile Ser Ile Thr Phe Pro Tyr Gly Met Val Thr Met 
    210                 215                 220                 


Ala Leu Val Asp Ala Asn Tyr Glu Met Pro Gly Glu Thr Leu Lys Val 
225                 230                 235                 240 


Arg Tyr Trp Pro Arg Asp Ser Trp Pro Val Gly Leu Pro Tyr Val Glu 
                245                 250                 255     


Ile Arg Gly Asp Asp Lys Asp Cys 
            260                 


<210>  5697
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  5697

Met Leu Pro Leu Ser Ile Lys Asp Asp Glu Tyr Lys Pro Pro Lys Phe 
1               5                   10                  15      


Asn Leu Phe Gly Lys Ile Ser Gly Trp Phe Arg Ser Ile Leu Ser Asp 
            20                  25                  30          


Lys Thr Ser Arg Asn Leu Phe Phe Phe Leu Cys Leu Asn Leu Ser Phe 
        35                  40                  45              


Ala Phe Val Glu Leu Leu Tyr Gly Ile Trp Ser Asn Cys Leu Gly Leu 
    50                  55                  60                  


Ile Ser Asp Ser Phe His Met Phe Phe Asp Ser Thr Ala Ile Leu Ala 
65                  70                  75                  80  


Gly Leu Ala Ala Ser Val Ile Ser Lys Trp Arg Asp Asn Asp Ala Phe 
                85                  90                  95      


Ser Tyr Gly Tyr Val Arg Ala Glu Val Leu Ala Gly Phe Val Asn Gly 
            100                 105                 110         


Leu Phe Leu Ile Phe Thr Ala Phe Phe Ile Phe Ser Glu Gly Val Glu 
        115                 120                 125             


Arg Ala Leu Ala Pro Pro Asp Val His His Glu Arg Leu Leu Leu Val 
    130                 135                 140                 


Ser Ile Leu Gly Phe Val Val Asn Leu Ile Gly Ile Phe Val Phe Lys 
145                 150                 155                 160 


His Gly Gly His Gly His Ser His Gly Ser Gly His Gly His Ser His 
                165                 170                 175     


Ser Leu Phe Asn Gly Ala Leu Asp Gln Ala His Gly His Val Asp His 
            180                 185                 190         


Cys His Ser His Glu Val Lys His Gly Ala Ala His Ser His Asp His 
        195                 200                 205             


Ala His Gly His Gly His Phe His Ser His Asp Gly Pro Ser Leu Lys 
    210                 215                 220                 


Glu Thr Thr Gly Pro Ser Arg Gln Ile Leu Gln Gly Val Phe Leu His 
225                 230                 235                 240 


Ile Leu Ala Asp Thr Leu Gly Ser Ile Gly Val Ile Ala Ser Ala Ile 
                245                 250                 255     


Met Met Gln Asn Phe Gly Leu Met Ile Ala Asp Pro Ile Cys Ser Ile 
            260                 265                 270         


Leu Ile Ala Ile Leu Ile Val Val Ser Val Ile Pro Leu Leu Arg Glu 
        275                 280                 285             


Ser Val Gly Ile Leu Met Gln Arg Thr Pro Pro Leu Leu Glu Asn Ser 
    290                 295                 300                 


Leu Pro Gln Cys Tyr Gln Arg Val Gln Gln Leu Gln Gly Val Tyr Ser 
305                 310                 315                 320 


Leu Gln Glu Gln His Phe Trp Thr Leu Cys Ser Asp Val Tyr Val Gly 
                325                 330                 335     


Thr Leu Lys Leu Ile Val Ala Pro Asp Ala Asp Ala Arg Trp Ile Leu 
            340                 345                 350         


Ser Gln Thr His Asn Ile Phe Thr Gln Ala Gly Val Arg Gln Leu Tyr 
        355                 360                 365             


Val Gln Ile Asp Phe Ala Ala Met 
    370                 375     


<210>  5698
<211>  545
<212>  PRT
<213>  Homo sapiens

<400>  5698

Met Leu Lys Gln Ser Glu Arg Arg Arg Ser Trp Ser Tyr Arg Pro Trp 
1               5                   10                  15      


Asn Thr Thr Glu Asn Glu Gly Ser Gln His Arg Arg Ser Ile Cys Ser 
            20                  25                  30          


Leu Gly Ala Arg Ser Gly Ser Gln Ala Ser Ile His Gly Trp Thr Glu 
        35                  40                  45              


Gly Asn Tyr Asn Tyr Tyr Ile Glu Glu Asp Glu Asp Gly Glu Glu Glu 
    50                  55                  60                  


Asp Gln Trp Lys Asp Asp Leu Ala Glu Glu Asp Gln Gln Ala Gly Glu 
65                  70                  75                  80  


Val Thr Thr Ala Lys Pro Glu Gly Pro Ser Asp Pro Pro Ala Leu Leu 
                85                  90                  95      


Ser Thr Leu Asn Val Asn Val Gly Gly His Ser Tyr Gln Leu Asp Tyr 
            100                 105                 110         


Cys Glu Leu Ala Gly Phe Pro Lys Thr Arg Leu Gly Arg Leu Ala Thr 
        115                 120                 125             


Ser Thr Ser Arg Ser Arg Gln Leu Ser Leu Cys Asp Asp Tyr Glu Glu 
    130                 135                 140                 


Gln Thr Asp Glu Tyr Phe Phe Asp Arg Asp Pro Ala Val Phe Gln Leu 
145                 150                 155                 160 


Val Tyr Asn Phe Tyr Leu Ser Gly Val Leu Leu Val Leu Asp Gly Leu 
                165                 170                 175     


Cys Pro Arg Arg Phe Leu Glu Glu Leu Gly Tyr Trp Gly Val Arg Leu 
            180                 185                 190         


Lys Tyr Thr Pro Arg Cys Cys Arg Ile Cys Phe Glu Glu Arg Arg Asp 
        195                 200                 205             


Glu Leu Ser Glu Arg Leu Lys Ile Gln His Glu Leu Arg Ala Gln Ala 
    210                 215                 220                 


Gln Val Glu Glu Ala Glu Glu Leu Phe Arg Asp Met Arg Phe Tyr Gly 
225                 230                 235                 240 


Pro Gln Arg Arg Arg Leu Trp Asn Leu Met Glu Lys Pro Phe Ser Ser 
                245                 250                 255     


Val Ala Ala Lys Ala Ile Gly Val Ala Ser Ser Thr Phe Val Leu Val 
            260                 265                 270         


Ser Val Val Ala Leu Ala Leu Asn Thr Val Glu Glu Met Gln Gln His 
        275                 280                 285             


Ser Gly Gln Gly Glu Gly Gly Pro Asp Leu Arg Pro Ile Leu Glu His 
    290                 295                 300                 


Val Glu Met Leu Cys Met Gly Phe Phe Thr Leu Glu Tyr Leu Leu Arg 
305                 310                 315                 320 


Leu Ala Ser Thr Pro Asp Leu Arg Arg Phe Ala Arg Ser Ala Leu Asn 
                325                 330                 335     


Leu Val Asp Leu Val Ala Ile Leu Pro Leu Tyr Leu Gln Leu Leu Leu 
            340                 345                 350         


Glu Cys Phe Thr Gly Glu Gly His Gln Arg Gly Gln Thr Val Gly Ser 
        355                 360                 365             


Val Gly Lys Val Gly Gln Val Leu Arg Val Met Arg Leu Met Arg Ile 
    370                 375                 380                 


Phe Arg Ile Leu Lys Leu Ala Arg His Ser Thr Gly Leu Arg Ala Phe 
385                 390                 395                 400 


Gly Phe Thr Leu Arg Gln Cys Tyr Gln Gln Val Gly Cys Leu Leu Leu 
                405                 410                 415     


Phe Ile Ala Met Gly Ile Phe Thr Phe Ser Ala Ala Val Tyr Ser Val 
            420                 425                 430         


Glu His Asp Val Pro Ser Thr Asn Phe Thr Thr Ile Pro His Ser Trp 
        435                 440                 445             


Trp Trp Ala Ala Val Ser Ile Ser Thr Val Gly Tyr Gly Asp Met Tyr 
    450                 455                 460                 


Pro Glu Thr His Leu Gly Arg Phe Phe Ala Phe Leu Cys Ile Ala Phe 
465                 470                 475                 480 


Gly Ile Ile Leu Asn Gly Met Pro Ile Ser Ile Leu Tyr Asn Lys Phe 
                485                 490                 495     


Ser Asp Tyr Tyr Ser Lys Leu Lys Ala Tyr Glu Tyr Thr Thr Ile Arg 
            500                 505                 510         


Arg Glu Arg Gly Glu Val Asn Phe Met Gln Arg Ala Arg Lys Lys Ile 
        515                 520                 525             


Ala Glu Cys Leu Leu Gly Ser Asn Pro Gln Leu Thr Pro Arg Gln Glu 
    530                 535                 540                 


Asn 
545 


<210>  5699
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  5699

Met Gly Ser Lys Lys Leu Lys Arg Val Gly Leu Ser Gln Glu Leu Cys 
1               5                   10                  15      


Asp Arg Leu Ser Arg His Gln Ile Leu Thr Cys Gln Asp Phe Leu Cys 
            20                  25                  30          


Leu Ser Pro Leu Glu Leu Met Lys Val Thr Gly Leu Ser Tyr Arg Gly 
        35                  40                  45              


Val His Glu Leu Leu Cys Met Val Ser Arg Ala Cys Ala Pro Lys Met 
    50                  55                  60                  


Gln Thr Ala Tyr Gly Ile Lys Ala Gln Arg Ser Ala Asp Phe Ser Pro 
65                  70                  75                  80  


Ala Phe Leu Ser Thr Thr Leu Ser Ala Leu Asp Glu Ala Leu His Gly 
                85                  90                  95      


Gly Val Ala Cys Gly Ser Leu Thr Glu Ile Thr Gly Pro Pro Gly Cys 
            100                 105                 110         


Gly Lys Thr Gln Phe Cys Ile Met Met Ser Ile Leu Ala Thr Leu Pro 
        115                 120                 125             


Thr Asn Met Gly Gly Leu Glu Gly Ala Val Val Tyr Ile Asp Thr Glu 
    130                 135                 140                 


Ser Ala Phe Ser Ala Glu Arg Leu Val Glu Ile Ala Glu Ser Arg Phe 
145                 150                 155                 160 


Pro Arg Tyr Phe Asn Thr Glu Glu Lys Leu Leu Leu Thr Ser Ser Lys 
                165                 170                 175     


Val His Leu Tyr Arg Glu Leu Thr Cys Asp Glu Val Leu Gln Arg Ile 
            180                 185                 190         


Glu Ser Leu Glu Glu Glu Ile Ile Ser Lys Gly Ile Lys Leu Val Ile 
        195                 200                 205             


Leu Asp Ser Val Ala Ser Val Val Arg Lys Glu Phe Asp Ala Gln Leu 
    210                 215                 220                 


Gln Gly Asn Leu Lys Glu Arg Asn Lys Phe Leu Ala Arg Glu Ala Ser 
225                 230                 235                 240 


Ser Leu Lys Tyr Leu Ala Glu Glu Phe Ser Ile Pro Val Ile Leu Thr 
                245                 250                 255     


Asn Gln Ile Thr Thr His Leu Ser Gly Ala Leu Ala Ser Gln Ala Asp 
            260                 265                 270         


Leu Val Ser Pro Ala Asp Asp Leu Ser Leu Ser Glu Gly Thr Ser Gly 
        275                 280                 285             


Ser Ser Cys Val Ile Ala Ala Leu Gly Asn Thr Trp Ser His Ser Val 
    290                 295                 300                 


Asn Thr Arg Leu Ile Leu Gln Tyr Leu Asp Ser Glu Arg Arg Gln Ile 
305                 310                 315                 320 


Leu Ile Ala Lys Ser Pro Leu Ala Pro Phe Thr Ser Phe Val Tyr Thr 
                325                 330                 335     


Ile Lys Glu Glu Gly Leu Val Leu Gln Glu Thr Thr Phe Cys Ser Val 
            340                 345                 350         


Thr Gln Ala Glu Leu Asn Trp Ala Pro Glu Ile Leu Pro Pro Gln Pro 
        355                 360                 365             


Pro Glu Gln Leu Gly Leu Gln Met Cys His His Thr Gln Leu Ile Phe 
    370                 375                 380                 


<210>  5700
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  5700

Met Gly Ser Lys Lys Leu Lys Arg Val Gly Leu Ser Gln Glu Leu Cys 
1               5                   10                  15      


Asp Arg Leu Ser Arg His Gln Ile Leu Thr Cys Gln Asp Phe Leu Cys 
            20                  25                  30          


Leu Ser Pro Leu Glu Leu Met Lys Val Thr Gly Leu Ser Tyr Arg Gly 
        35                  40                  45              


Val His Glu Leu Leu Cys Met Val Ser Arg Ala Cys Ala Pro Lys Met 
    50                  55                  60                  


Gln Thr Ala Tyr Gly Ile Lys Ala Gln Arg Ser Ala Asp Phe Ser Pro 
65                  70                  75                  80  


Ala Phe Leu Ser Thr Thr Leu Ser Ala Leu Asp Glu Ala Leu His Gly 
                85                  90                  95      


Gly Val Ala Cys Gly Ser Leu Thr Glu Ile Thr Gly Pro Pro Gly Cys 
            100                 105                 110         


Gly Lys Thr Gln Phe Cys Ile Met Met Ser Ile Leu Ala Thr Leu Pro 
        115                 120                 125             


Thr Asn Met Gly Gly Leu Glu Gly Ala Val Val Tyr Ile Asp Thr Glu 
    130                 135                 140                 


Ser Ala Phe Ser Ala Glu Arg Leu Val Glu Ile Ala Glu Ser Arg Phe 
145                 150                 155                 160 


Pro Arg Tyr Phe Asn Thr Glu Glu Lys Leu Leu Leu Thr Ser Ser Lys 
                165                 170                 175     


Val His Leu Tyr Arg Glu Leu Thr Cys Asp Glu Val Leu Gln Arg Ile 
            180                 185                 190         


Glu Ser Leu Glu Glu Glu Ile Ile Ser Lys Gly Ile Lys Leu Val Ile 
        195                 200                 205             


Leu Asp Ser Val Ala Ser Val Val Arg Lys Glu Phe Asp Ala Gln Leu 
    210                 215                 220                 


Gln Gly Asn Leu Lys Glu Arg Asn Lys Phe Leu Ala Arg Glu Ala Ser 
225                 230                 235                 240 


Ser Leu Lys Tyr Leu Ala Glu Glu Phe Ser Ile Pro Val Ile Leu Thr 
                245                 250                 255     


Asn Gln Ile Thr Thr His Leu Ser Gly Ala Leu Ala Ser Gln Ala Asp 
            260                 265                 270         


Leu Val Ser Pro Ala Asp Asp Leu Ser Leu Ser Glu Gly Thr Ser Gly 
        275                 280                 285             


Ser Ser Cys Val Ile Ala Ala Leu Gly Asn Thr Trp Ser His Ser Val 
    290                 295                 300                 


Asn Thr Arg Leu Ile Leu Gln Tyr Leu Asp Ser Glu Arg Arg Gln Ile 
305                 310                 315                 320 


Leu Ile Ala Lys Ser Pro Leu Ala Pro Phe Thr Ser Phe Val Tyr Thr 
                325                 330                 335     


Ile Lys Glu Glu Gly Leu Val Leu Gln Gly Gln Glu Lys Pro 
            340                 345                 350 


<210>  5701
<211>  756
<212>  PRT
<213>  Homo sapiens

<400>  5701

Met Leu Gly Ile Cys Arg Gly Arg Arg Lys Phe Leu Ala Ala Ser Leu 
1               5                   10                  15      


Ser Leu Leu Cys Ile Pro Ala Ile Thr Trp Ile Tyr Leu Phe Ser Gly 
            20                  25                  30          


Ser Phe Glu Asp Gly Lys Pro Val Ser Leu Ser Pro Leu Glu Ser Gln 
        35                  40                  45              


Ala His Ser Pro Arg Tyr Thr Ala Ser Ser Gln Arg Glu Arg Glu Ser 
    50                  55                  60                  


Leu Glu Val Arg Met Arg Glu Val Glu Glu Glu Asn Arg Ala Leu Arg 
65                  70                  75                  80  


Arg Gln Leu Ser Leu Ala Gln Gly Arg Ala Pro Ser His Arg Arg Gly 
                85                  90                  95      


Asn His Ser Lys Thr Tyr Ser Met Glu Glu Gly Thr Gly Asp Ser Glu 
            100                 105                 110         


Asn Leu Arg Ala Gly Ile Val Ala Gly Asn Ser Ser Glu Cys Gly Gln 
        115                 120                 125             


Gln Pro Val Val Glu Lys Cys Glu Thr Ile His Val Ala Ile Val Cys 
    130                 135                 140                 


Ala Gly Tyr Asn Ala Ser Arg Asp Val Val Thr Leu Val Lys Ser Val 
145                 150                 155                 160 


Leu Phe His Arg Arg Asn Pro Leu His Phe His Leu Ile Ala Asp Ser 
                165                 170                 175     


Ile Ala Glu Gln Ile Leu Ala Thr Leu Phe Gln Thr Trp Met Val Pro 
            180                 185                 190         


Ala Val Arg Val Asp Phe Tyr Asn Ala Asp Glu Leu Lys Ser Glu Val 
        195                 200                 205             


Ser Trp Ile Pro Asn Lys His Tyr Ser Gly Ile Tyr Gly Leu Met Lys 
    210                 215                 220                 


Leu Val Leu Thr Lys Thr Leu Pro Ala Asn Leu Glu Arg Val Ile Val 
225                 230                 235                 240 


Leu Asp Thr Asp Ile Thr Phe Ala Thr Asp Ile Ala Glu Leu Trp Ala 
                245                 250                 255     


Val Phe His Lys Phe Lys Gly Gln Gln Val Leu Gly Leu Val Glu Asn 
            260                 265                 270         


Gln Ser Asp Trp Tyr Leu Gly Asn Leu Trp Lys Asn His Arg Pro Trp 
        275                 280                 285             


Pro Ala Leu Gly Arg Gly Tyr Asn Thr Gly Val Ile Leu Leu Leu Leu 
    290                 295                 300                 


Asp Lys Leu Arg Lys Met Lys Trp Glu Gln Met Trp Arg Leu Thr Ala 
305                 310                 315                 320 


Glu Arg Glu Leu Met Gly Met Leu Ser Thr Ser Leu Ala Asp Gln Asp 
                325                 330                 335     


Ile Phe Asn Ala Val Ile Lys Gln Asn Pro Phe Leu Val Tyr Gln Leu 
            340                 345                 350         


Pro Cys Phe Trp Asn Val Gln Leu Ser Asp His Thr Arg Ser Glu Gln 
        355                 360                 365             


Cys Tyr Arg Asp Val Ser Asp Leu Lys Val Ile His Trp Asn Ser Pro 
    370                 375                 380                 


Lys Lys Leu Arg Val Lys Asn Lys His Val Glu Phe Phe Arg Asn Leu 
385                 390                 395                 400 


Tyr Leu Thr Phe Leu Glu Tyr Asp Gly Asn Leu Leu Arg Arg Glu Leu 
                405                 410                 415     


Phe Gly Cys Pro Ser Glu Ala Asp Val Asn Ser Glu Asn Leu Gln Lys 
            420                 425                 430         


Gln Leu Ser Glu Leu Asp Glu Asp Asp Leu Cys Tyr Glu Phe Arg Arg 
        435                 440                 445             


Glu Arg Phe Thr Val His Arg Thr His Leu Tyr Phe Leu His Tyr Glu 
    450                 455                 460                 


Tyr Glu Pro Ala Ala Asp Ser Thr Asp Val Thr Leu Val Ala Gln Leu 
465                 470                 475                 480 


Ser Met Asp Arg Leu Gln Met Leu Glu Ala Ile Cys Lys His Trp Glu 
                485                 490                 495     


Gly Pro Ile Ser Leu Ala Leu Tyr Leu Ser Asp Ala Glu Ala Gln Gln 
            500                 505                 510         


Phe Leu Arg Tyr Ala Gln Gly Ser Glu Val Leu Met Ser Arg His Asn 
        515                 520                 525             


Val Gly Tyr His Ile Val Tyr Lys Glu Gly Gln Phe Tyr Pro Val Asn 
    530                 535                 540                 


Leu Leu Arg Asn Val Ala Met Lys His Ile Ser Thr Pro Tyr Met Phe 
545                 550                 555                 560 


Leu Ser Asp Ile Asp Phe Leu Pro Met Tyr Gly Leu Tyr Glu Tyr Leu 
                565                 570                 575     


Arg Lys Ser Val Ile Gln Leu Asp Leu Ala Asn Thr Lys Lys Ala Met 
            580                 585                 590         


Ile Val Pro Ala Phe Glu Thr Leu Arg Tyr Arg Leu Ser Phe Pro Lys 
        595                 600                 605             


Ser Lys Ala Glu Leu Leu Ser Met Leu Asp Met Gly Thr Leu Phe Thr 
    610                 615                 620                 


Phe Arg Tyr His Val Trp Thr Lys Gly His Ala Pro Thr Asn Phe Ala 
625                 630                 635                 640 


Lys Trp Arg Thr Ala Thr Thr Pro Tyr Arg Val Glu Trp Glu Ala Asp 
                645                 650                 655     


Phe Glu Pro Tyr Val Val Val Arg Arg Asp Cys Pro Glu Tyr Asp Arg 
            660                 665                 670         


Arg Phe Val Gly Phe Gly Trp Asn Lys Val Ala His Ile Met Glu Leu 
        675                 680                 685             


Asp Val Gln Glu Tyr Glu Phe Ile Val Leu Pro Asn Ala Tyr Met Ile 
    690                 695                 700                 


His Met Pro His Ala Pro Ser Phe Asp Ile Thr Lys Phe Arg Ser Asn 
705                 710                 715                 720 


Lys Gln Tyr Arg Ile Cys Leu Lys Thr Leu Lys Glu Glu Phe Gln Gln 
                725                 730                 735     


Asp Met Ser Arg Arg Tyr Gly Phe Ala Ala Leu Lys Tyr Leu Thr Ala 
            740                 745                 750         


Glu Asn Asn Ser 
        755     


<210>  5702
<211>  1150
<212>  PRT
<213>  Homo sapiens

<400>  5702

Met His Pro Pro Glu Thr Thr Thr Lys Met Ala Ser Val Arg Phe Met 
1               5                   10                  15      


Val Thr Pro Thr Lys Ile Asp Asp Ile Pro Gly Leu Ser Asp Thr Ser 
            20                  25                  30          


Pro Asp Leu Ser Ser Arg Ser Ser Ser Arg Val Arg Phe Ser Ser Arg 
        35                  40                  45              


Glu Ser Val Pro Glu Thr Ser Arg Ser Glu Pro Met Ser Glu Met Ser 
    50                  55                  60                  


Gly Ala Thr Thr Ser Leu Ala Thr Val Ala Leu Asp Pro Pro Ser Asp 
65                  70                  75                  80  


Arg Thr Ser His Pro Gln Asp Val Ile Glu Asp Leu Ser Gln Asn Ser 
                85                  90                  95      


Ile Thr Gly Glu His Ser Gln Leu Leu Asp Asp Gly His Lys Lys Ala 
            100                 105                 110         


Arg Asn Ala Tyr Leu Asn Asn Ser Asn Tyr Glu Glu Gly Asp Glu Tyr 
        115                 120                 125             


Phe Asp Lys Asn Leu Ala Leu Phe Glu Glu Glu Met Asp Thr Arg Pro 
    130                 135                 140                 


Lys Val Ser Ser Leu Leu Asn Arg Met Ala Asn Tyr Thr Asn Leu Thr 
145                 150                 155                 160 


Gln Gly Ala Lys Glu His Glu Glu Ala Glu Asn Ile Thr Glu Gly Lys 
                165                 170                 175     


Lys Lys Pro Thr Lys Thr Pro Gln Met Gly Thr Phe Met Gly Val Tyr 
            180                 185                 190         


Leu Pro Cys Leu Gln Asn Ile Phe Gly Val Ile Leu Phe Leu Arg Leu 
        195                 200                 205             


Thr Trp Val Val Gly Thr Ala Gly Val Leu Gln Ala Phe Ala Ile Val 
    210                 215                 220                 


Leu Ile Cys Cys Cys Cys Thr Met Leu Thr Ala Ile Ser Met Ser Ala 
225                 230                 235                 240 


Ile Ala Thr Asn Gly Val Val Pro Ala Gly Gly Ser Tyr Phe Met Ile 
                245                 250                 255     


Ser Arg Ala Leu Gly Pro Glu Phe Gly Gly Ala Val Gly Leu Cys Phe 
            260                 265                 270         


Tyr Leu Gly Thr Thr Phe Ala Ala Ala Met Tyr Ile Leu Gly Ala Ile 
        275                 280                 285             


Glu Ile Phe Leu Val Tyr Ile Val Pro Arg Ala Ala Ile Phe His Ser 
    290                 295                 300                 


Asp Asp Ala Leu Lys Glu Ser Ala Ala Met Leu Asn Asn Met Arg Val 
305                 310                 315                 320 


Tyr Gly Thr Ala Phe Leu Val Leu Met Val Leu Val Val Phe Ile Gly 
                325                 330                 335     


Val Arg Tyr Val Asn Lys Phe Ala Ser Leu Phe Leu Ala Cys Val Ile 
            340                 345                 350         


Val Ser Ile Leu Ala Ile Tyr Ala Gly Ala Ile Lys Ser Ser Phe Ala 
        355                 360                 365             


Pro Pro His Phe Pro Val Cys Met Leu Gly Asn Arg Thr Leu Ser Ser 
    370                 375                 380                 


Arg His Ile Asp Val Cys Ser Lys Thr Lys Glu Ile Asn Asn Met Thr 
385                 390                 395                 400 


Val Pro Ser Lys Leu Trp Gly Phe Phe Cys Asn Ser Ser Gln Phe Phe 
                405                 410                 415     


Asn Ala Thr Cys Asp Glu Tyr Phe Val His Asn Asn Val Thr Ser Ile 
            420                 425                 430         


Gln Gly Ile Pro Gly Leu Ala Ser Gly Ile Ile Thr Glu Asn Leu Trp 
        435                 440                 445             


Ser Asn Tyr Leu Pro Lys Gly Glu Ile Ile Glu Lys Pro Ser Ala Lys 
    450                 455                 460                 


Ser Ser Asp Val Leu Gly Ser Leu Asn His Glu Tyr Val Leu Val Asp 
465                 470                 475                 480 


Ile Thr Thr Ser Phe Thr Leu Leu Val Gly Ile Phe Phe Pro Ser Val 
                485                 490                 495     


Thr Gly Ile Met Ala Gly Ser Asn Arg Ser Gly Asp Leu Lys Asp Ala 
            500                 505                 510         


Gln Lys Ser Ile Pro Ile Gly Thr Ile Leu Ala Ile Leu Thr Thr Ser 
        515                 520                 525             


Phe Val Tyr Leu Ser Asn Val Val Leu Phe Gly Ala Cys Ile Glu Gly 
    530                 535                 540                 


Val Val Leu Arg Asp Lys Phe Gly Asp Ala Val Lys Gly Asn Leu Val 
545                 550                 555                 560 


Val Gly Thr Leu Ser Trp Pro Ser Pro Trp Val Ile Val Ile Gly Ser 
                565                 570                 575     


Phe Phe Ser Thr Cys Gly Ala Gly Leu Gln Ser Leu Thr Gly Ala Pro 
            580                 585                 590         


Arg Leu Leu Gln Ala Ile Ala Lys Asp Asn Ile Ile Pro Phe Leu Arg 
        595                 600                 605             


Val Phe Gly His Ser Lys Ala Asn Gly Glu Pro Thr Trp Ala Leu Leu 
    610                 615                 620                 


Leu Thr Ala Ala Ile Ala Glu Leu Gly Ile Leu Ile Ala Ser Leu Asp 
625                 630                 635                 640 


Leu Val Ala Pro Ile Leu Ser Met Phe Phe Leu Met Cys Tyr Leu Phe 
                645                 650                 655     


Val Asn Leu Ala Cys Ala Leu Gln Thr Leu Leu Arg Thr Pro Asn Trp 
            660                 665                 670         


Arg Pro Arg Phe Arg Tyr Tyr His Trp Ala Leu Ser Phe Met Gly Met 
        675                 680                 685             


Ser Ile Cys Leu Ala Leu Met Phe Ile Ser Ser Trp Tyr Tyr Ala Ile 
    690                 695                 700                 


Val Ala Met Val Ile Ala Gly Met Ile Tyr Lys Tyr Ile Glu Tyr Gln 
705                 710                 715                 720 


Gly Ala Glu Lys Glu Trp Gly Asp Gly Ile Arg Gly Leu Ser Leu Ser 
                725                 730                 735     


Ala Ala Arg Phe Ala Leu Leu Arg Leu Glu Glu Gly Pro Pro His Thr 
            740                 745                 750         


Lys Asn Trp Arg Pro Gln Leu Leu Val Leu Leu Lys Leu Asp Glu Asp 
        755                 760                 765             


Leu His Val Lys His Pro Arg Leu Leu Thr Phe Ala Ser Gln Leu Lys 
    770                 775                 780                 


Ala Gly Lys Gly Leu Thr Ile Val Gly Ser Val Ile Val Gly Asn Phe 
785                 790                 795                 800 


Leu Glu Asn Tyr Gly Glu Ala Leu Ala Ala Glu Gln Thr Ile Lys His 
                805                 810                 815     


Leu Met Glu Ala Glu Lys Val Lys Gly Phe Cys Gln Leu Val Val Ala 
            820                 825                 830         


Ala Lys Leu Arg Glu Gly Ile Ser His Leu Ile Gln Ser Cys Gly Leu 
        835                 840                 845             


Gly Gly Met Lys His Asn Thr Val Val Met Gly Trp Pro Asn Gly Trp 
    850                 855                 860                 


Arg Gln Ser Glu Asp Ala Arg Ala Trp Lys Thr Phe Ile Gly Thr Val 
865                 870                 875                 880 


Arg Val Thr Thr Ala Ala His Leu Ala Leu Leu Val Ala Lys Asn Ile 
                885                 890                 895     


Ser Phe Phe Pro Ser Asn Val Glu Gln Phe Ser Glu Gly Asn Ile Asp 
            900                 905                 910         


Val Trp Trp Ile Val His Asp Gly Gly Met Leu Met Leu Leu Pro Phe 
        915                 920                 925             


Leu Leu Lys Gln His Lys Val Trp Arg Lys Cys Ser Ile Arg Ile Phe 
    930                 935                 940                 


Thr Val Ala Gln Leu Glu Asp Asn Ser Ile Gln Met Lys Lys Asp Leu 
945                 950                 955                 960 


Ala Thr Phe Leu Tyr His Leu Arg Ile Glu Ala Glu Val Glu Val Val 
                965                 970                 975     


Glu Met His Asp Ser Asp Ile Ser Ala Tyr Thr Tyr Glu Arg Thr Leu 
            980                 985                 990         


Met Met Glu Gln Arg Ser Gln Met  Leu Arg His Met Arg  Leu Ser Lys 
        995                 1000                 1005             


Thr Glu  Arg Asp Arg Glu Ala  Gln Leu Val Lys Asp  Arg Asn Ser 
    1010                 1015                 1020             


Met Leu  Arg Leu Thr Ser Ile  Gly Ser Asp Glu Asp  Glu Glu Thr 
    1025                 1030                 1035             


Glu Thr  Tyr Gln Glu Lys Val  His Met Thr Trp Thr  Lys Asp Lys 
    1040                 1045                 1050             


Tyr Met  Ala Ser Arg Gly Gln  Lys Ala Lys Ser Met  Glu Gly Phe 
    1055                 1060                 1065             


Gln Asp  Leu Leu Asn Met Arg  Pro Asp Gln Ser Asn  Val Arg Arg 
    1070                 1075                 1080             


Met His  Thr Ala Val Lys Leu  Asn Glu Val Ile Val  Asn Lys Ser 
    1085                 1090                 1095             


His Glu  Ala Lys Leu Val Leu  Leu Asn Met Pro Gly  Pro Pro Arg 
    1100                 1105                 1110             


Asn Pro  Glu Gly Asp Glu Asn  Tyr Met Glu Phe Leu  Glu Val Leu 
    1115                 1120                 1125             


Thr Glu  Gly Leu Glu Arg Val  Leu Leu Val Arg Gly  Gly Gly Ser 
    1130                 1135                 1140             


Glu Val  Ile Thr Ile Tyr Ser  
    1145                 1150 


<210>  5703
<211>  758
<212>  PRT
<213>  Homo sapiens

<400>  5703

Met Gly Leu Ala Asp Ala Ser Gly Pro Arg Asp Thr Gln Ala Leu Leu 
1               5                   10                  15      


Ser Ala Thr Gln Ala Met Asp Leu Arg Arg Arg Asp Tyr His Met Glu 
            20                  25                  30          


Arg Pro Leu Leu Asn Gln Glu His Leu Glu Glu Leu Gly Arg Trp Gly 
        35                  40                  45              


Ser Ala Pro Arg Thr His Gln Trp Arg Thr Trp Leu Gln Cys Ser Arg 
    50                  55                  60                  


Ala Arg Ala Tyr Ala Leu Leu Leu Gln His Leu Pro Val Leu Val Trp 
65                  70                  75                  80  


Leu Pro Arg Tyr Pro Val Arg Asp Trp Leu Leu Gly Asp Leu Leu Ser 
                85                  90                  95      


Gly Leu Ser Val Ala Ile Met Gln Leu Pro Gln Gly Leu Ala Tyr Ala 
            100                 105                 110         


Leu Leu Ala Gly Leu Pro Pro Val Phe Gly Leu Tyr Ser Ser Phe Tyr 
        115                 120                 125             


Pro Val Phe Ile Tyr Phe Leu Phe Gly Thr Ser Arg His Ile Ser Val 
    130                 135                 140                 


Gly Thr Phe Ala Val Met Ser Val Met Val Gly Ser Val Thr Glu Ser 
145                 150                 155                 160 


Leu Ala Pro Gln Ala Leu Asn Asp Ser Met Ile Asn Glu Thr Ala Arg 
                165                 170                 175     


Asp Ala Ala Arg Val Gln Val Ala Ser Thr Leu Ser Val Leu Val Gly 
            180                 185                 190         


Leu Phe Gln Val Gly Leu Gly Leu Ile His Phe Gly Phe Val Val Thr 
        195                 200                 205             


Tyr Leu Ser Glu Pro Leu Val Arg Gly Tyr Thr Thr Ala Ala Ala Val 
    210                 215                 220                 


Gln Val Phe Val Ser Gln Leu Lys Tyr Val Phe Gly Leu His Leu Ser 
225                 230                 235                 240 


Ser His Ser Gly Pro Leu Ser Leu Ile Tyr Thr Val Leu Glu Val Cys 
                245                 250                 255     


Trp Lys Leu Pro Gln Ser Lys Val Gly Thr Val Val Thr Ala Ala Val 
            260                 265                 270         


Ala Gly Val Val Leu Val Val Val Lys Leu Leu Asn Asp Lys Leu Gln 
        275                 280                 285             


Gln Gln Leu Pro Met Pro Ile Pro Gly Glu Leu Leu Thr Leu Ile Gly 
    290                 295                 300                 


Ala Thr Gly Ile Ser Tyr Gly Met Gly Leu Lys His Arg Phe Glu Val 
305                 310                 315                 320 


Asp Val Val Gly Asn Ile Pro Ala Gly Leu Val Pro Pro Val Ala Pro 
                325                 330                 335     


Asn Thr Gln Leu Phe Ser Lys Leu Val Gly Ser Ala Phe Thr Ile Ala 
            340                 345                 350         


Val Val Gly Phe Ala Ile Ala Ile Ser Leu Gly Lys Ile Phe Ala Leu 
        355                 360                 365             


Arg His Gly Tyr Arg Val Asp Ser Asn Gln Glu Leu Val Ala Leu Gly 
    370                 375                 380                 


Leu Ser Asn Leu Ile Gly Gly Ile Phe Gln Cys Phe Pro Val Ser Cys 
385                 390                 395                 400 


Ser Met Ser Arg Ser Leu Val Gln Glu Ser Thr Gly Gly Asn Ser Gln 
                405                 410                 415     


Val Ala Gly Ala Ile Ser Ser Leu Phe Ile Leu Leu Ile Ile Val Lys 
            420                 425                 430         


Leu Gly Glu Leu Phe His Asp Leu Pro Lys Ala Val Leu Ala Ala Ile 
        435                 440                 445             


Ile Ile Val Asn Leu Lys Gly Met Leu Arg Gln Leu Ser Asp Met Arg 
    450                 455                 460                 


Ser Leu Trp Lys Ala Asn Arg Ala Asp Leu Leu Ile Trp Leu Val Thr 
465                 470                 475                 480 


Phe Thr Ala Thr Ile Leu Leu Asn Leu Asp Leu Gly Leu Val Val Ala 
                485                 490                 495     


Val Ile Phe Ser Leu Leu Leu Val Val Val Arg Thr Gln Met Pro His 
            500                 505                 510         


Tyr Ser Val Leu Gly Gln Val Pro Asp Thr Asp Ile Tyr Arg Asp Val 
        515                 520                 525             


Ala Glu Tyr Ser Glu Ala Lys Glu Val Arg Gly Val Lys Val Phe Arg 
    530                 535                 540                 


Ser Ser Ala Thr Val Tyr Phe Ala Asn Ala Glu Phe Tyr Ser Asp Ala 
545                 550                 555                 560 


Leu Lys Gln Arg Cys Gly Val Asp Val Asp Phe Leu Ile Ser Gln Lys 
                565                 570                 575     


Lys Lys Leu Leu Lys Lys Gln Glu Gln Leu Lys Leu Lys Gln Leu Gln 
            580                 585                 590         


Lys Glu Glu Lys Leu Arg Lys Gln Ala Ala Ser Pro Lys Gly Ala Ser 
        595                 600                 605             


Val Ser Ile Asn Val Asn Thr Ser Leu Glu Asp Met Arg Ser Asn Asn 
    610                 615                 620                 


Val Glu Asp Cys Lys Met Met Val Ser Ser Gly Asp Lys Met Glu Asp 
625                 630                 635                 640 


Ala Thr Ala Asn Gly Gln Glu Asp Ser Lys Ala Pro Asp Gly Ser Thr 
                645                 650                 655     


Leu Lys Ala Leu Gly Leu Pro Gln Pro Asp Phe His Ser Leu Ile Leu 
            660                 665                 670         


Asp Leu Gly Ala Leu Ser Phe Val Asp Thr Val Cys Leu Lys Ser Leu 
        675                 680                 685             


Lys Asn Ile Phe His Asp Phe Arg Glu Ile Glu Val Glu Val Tyr Met 
    690                 695                 700                 


Ala Ala Cys His Ser Pro Val Val Ser Gln Leu Glu Ala Gly His Phe 
705                 710                 715                 720 


Phe Asp Ala Ser Ile Thr Lys Lys His Leu Phe Ala Ser Val His Asp 
                725                 730                 735     


Ala Val Thr Phe Ala Leu Gln His Pro Arg Pro Val Pro Asp Ser Pro 
            740                 745                 750         


Val Ser Val Thr Arg Leu 
        755             


<210>  5704
<211>  3312
<212>  PRT
<213>  Homo sapiens

<400>  5704

Met Met Ala Arg Arg Pro Pro Trp Arg Gly Leu Gly Gly Arg Ser Thr 
1               5                   10                  15      


Pro Ile Leu Leu Leu Leu Leu Leu Ser Leu Phe Pro Leu Ser Gln Glu 
            20                  25                  30          


Glu Leu Gly Gly Gly Gly His Gln Gly Trp Asp Pro Gly Leu Ala Ala 
        35                  40                  45              


Thr Thr Gly Pro Arg Ala His Ile Gly Gly Gly Ala Leu Ala Leu Cys 
    50                  55                  60                  


Pro Glu Ser Ser Gly Val Arg Glu Asp Gly Gly Pro Gly Leu Gly Val 
65                  70                  75                  80  


Arg Glu Pro Ile Phe Val Gly Leu Arg Gly Arg Arg Gln Ser Ala Arg 
                85                  90                  95      


Asn Ser Arg Gly Pro Pro Glu Gln Pro Asn Glu Glu Leu Gly Ile Glu 
            100                 105                 110         


His Gly Val Gln Pro Leu Gly Ser Arg Glu Arg Glu Thr Gly Gln Gly 
        115                 120                 125             


Pro Gly Ser Val Leu Tyr Trp Arg Pro Glu Val Ser Ser Cys Gly Arg 
    130                 135                 140                 


Thr Gly Pro Leu Gln Arg Gly Ser Leu Ser Pro Gly Ala Leu Ser Ser 
145                 150                 155                 160 


Gly Val Pro Gly Ser Gly Asn Ser Ser Pro Leu Pro Ser Asp Phe Leu 
                165                 170                 175     


Ile Arg His His Gly Pro Lys Pro Val Ser Ser Gln Arg Asn Ala Gly 
            180                 185                 190         


Thr Gly Ser Arg Lys Arg Val Gly Thr Ala Arg Cys Cys Gly Glu Leu 
        195                 200                 205             


Trp Ala Thr Gly Ser Lys Gly Gln Gly Glu Arg Ala Thr Thr Ser Gly 
    210                 215                 220                 


Ala Glu Arg Thr Ala Pro Arg Arg Asn Cys Leu Pro Gly Ala Ser Gly 
225                 230                 235                 240 


Ser Gly Pro Glu Leu Asp Ser Ala Pro Arg Thr Ala Arg Thr Ala Pro 
                245                 250                 255     


Ala Ser Gly Ser Ala Pro Arg Glu Ser Arg Thr Ala Pro Glu Pro Ala 
            260                 265                 270         


Pro Lys Arg Met Arg Ser Arg Gly Leu Phe Arg Cys Arg Phe Leu Pro 
        275                 280                 285             


Gln Arg Pro Gly Pro Arg Pro Pro Gly Leu Pro Ala Arg Pro Glu Ala 
    290                 295                 300                 


Arg Lys Val Thr Ser Ala Asn Arg Ala Arg Phe Arg Arg Ala Ala Asn 
305                 310                 315                 320 


Arg His Pro Gln Phe Pro Gln Tyr Asn Tyr Gln Thr Leu Val Pro Glu 
                325                 330                 335     


Asn Glu Ala Ala Gly Thr Ala Val Leu Arg Val Val Ala Gln Asp Pro 
            340                 345                 350         


Asp Ala Gly Glu Ala Gly Arg Leu Val Tyr Ser Leu Ala Ala Leu Met 
        355                 360                 365             


Asn Ser Arg Ser Leu Glu Leu Phe Ser Ile Asp Pro Gln Ser Gly Leu 
    370                 375                 380                 


Ile Arg Thr Ala Ala Ala Leu Asp Arg Glu Ser Met Glu Arg His Tyr 
385                 390                 395                 400 


Leu Arg Val Thr Ala Gln Asp His Gly Ser Pro Arg Leu Ser Ala Thr 
                405                 410                 415     


Thr Met Val Ala Val Thr Val Ala Asp Arg Asn Asp His Ser Pro Val 
            420                 425                 430         


Phe Glu Gln Ala Gln Tyr Arg Glu Thr Leu Arg Glu Asn Val Glu Glu 
        435                 440                 445             


Gly Tyr Pro Ile Leu Gln Leu Arg Ala Thr Asp Gly Asp Ala Pro Pro 
    450                 455                 460                 


Asn Ala Asn Leu Arg Tyr Arg Phe Val Gly Pro Pro Ala Ala Arg Ala 
465                 470                 475                 480 


Ala Ala Ala Ala Ala Phe Glu Ile Asp Pro Arg Ser Gly Leu Ile Ser 
                485                 490                 495     


Thr Ser Gly Arg Val Asp Arg Glu His Met Glu Ser Tyr Glu Leu Val 
            500                 505                 510         


Val Glu Ala Ser Asp Gln Gly Gln Glu Pro Gly Pro Arg Ser Ala Thr 
        515                 520                 525             


Val Arg Val His Ile Thr Val Leu Asp Glu Asn Asp Asn Ala Pro Gln 
    530                 535                 540                 


Phe Ser Glu Lys Arg Tyr Val Ala Gln Val Arg Glu Asp Val Arg Pro 
545                 550                 555                 560 


His Thr Val Val Leu Arg Val Thr Ala Thr Asp Arg Asp Lys Asp Ala 
                565                 570                 575     


Asn Gly Leu Val His Tyr Asn Ile Ile Ser Gly Asn Ser Arg Gly His 
            580                 585                 590         


Phe Ala Ile Asp Ser Leu Thr Gly Glu Ile Gln Val Val Ala Pro Leu 
        595                 600                 605             


Asp Phe Glu Ala Glu Arg Glu Tyr Ala Leu Arg Ile Arg Ala Gln Asp 
    610                 615                 620                 


Ala Gly Arg Pro Pro Leu Ser Asn Asn Thr Gly Leu Ala Ser Ile Gln 
625                 630                 635                 640 


Val Val Asp Ile Asn Asp His Ile Pro Ile Phe Val Ser Thr Pro Phe 
                645                 650                 655     


Gln Val Ser Val Leu Glu Asn Ala Pro Leu Gly His Ser Val Ile His 
            660                 665                 670         


Ile Gln Ala Val Asp Ala Asp His Gly Glu Asn Ala Arg Leu Glu Tyr 
        675                 680                 685             


Ser Leu Thr Gly Val Ala Pro Asp Thr Pro Phe Val Ile Asn Ser Ala 
    690                 695                 700                 


Thr Gly Trp Val Ser Val Ser Gly Pro Leu Asp Arg Glu Ser Val Glu 
705                 710                 715                 720 


His Tyr Phe Phe Gly Val Glu Ala Arg Asp His Gly Ser Pro Pro Leu 
                725                 730                 735     


Ser Ala Ser Ala Ser Val Thr Val Thr Val Leu Asp Val Asn Asp Asn 
            740                 745                 750         


Arg Pro Glu Phe Thr Met Lys Glu Tyr His Leu Arg Leu Asn Glu Asp 
        755                 760                 765             


Ala Ala Val Gly Thr Ser Val Val Ser Val Thr Ala Val Asp Arg Asp 
    770                 775                 780                 


Ala Asn Ser Ala Ile Ser Tyr Gln Ile Thr Gly Gly Asn Thr Arg Asn 
785                 790                 795                 800 


Arg Phe Ala Ile Ser Thr Gln Gly Gly Val Gly Leu Val Thr Leu Ala 
                805                 810                 815     


Leu Pro Leu Asp Tyr Lys Gln Glu Arg Tyr Phe Lys Leu Val Leu Thr 
            820                 825                 830         


Ala Ser Asp Arg Ala Leu His Asp His Cys Tyr Val His Ile Asn Ile 
        835                 840                 845             


Thr Asp Ala Asn Thr His Arg Pro Val Phe Gln Ser Ala His Tyr Ser 
    850                 855                 860                 


Val Ser Val Asn Glu Asp Arg Pro Met Gly Ser Thr Ile Val Val Ile 
865                 870                 875                 880 


Ser Ala Ser Asp Asp Asp Val Gly Glu Asn Ala Arg Ile Thr Tyr Leu 
                885                 890                 895     


Leu Glu Asp Asn Leu Pro Gln Phe Arg Ile Asp Ala Asp Ser Gly Ala 
            900                 905                 910         


Ile Thr Leu Gln Ala Pro Leu Asp Tyr Glu Asp Gln Val Thr Tyr Thr 
        915                 920                 925             


Leu Ala Ile Thr Ala Arg Asp Asn Gly Ile Pro Gln Lys Ala Asp Thr 
    930                 935                 940                 


Thr Tyr Val Glu Val Met Val Asn Asp Val Asn Asp Asn Ala Pro Gln 
945                 950                 955                 960 


Phe Val Ala Ser His Tyr Thr Gly Leu Val Ser Glu Asp Ala Pro Pro 
                965                 970                 975     


Phe Thr Ser Val Leu Gln Ile Ser Ala Thr Asp Arg Asp Ala His Ala 
            980                 985                 990         


Asn Gly Arg Val Gln Tyr Thr Phe  Gln Asn Gly Glu Asp  Gly Asp Gly 
        995                 1000                 1005             


Asp Phe  Thr Ile Glu Pro Thr  Ser Gly Ile Val Arg  Thr Val Arg 
    1010                 1015                 1020             


Arg Leu  Asp Arg Glu Ala Val  Ser Val Tyr Glu Leu  Thr Ala Tyr 
    1025                 1030                 1035             


Ala Val  Asp Arg Gly Val Pro  Pro Leu Arg Thr Pro  Val Ser Ile 
    1040                 1045                 1050             


Gln Val  Met Val Gln Asp Val  Asn Asp Asn Ala Pro  Val Phe Pro 
    1055                 1060                 1065             


Ala Glu  Glu Phe Glu Val Arg  Val Lys Glu Asn Ser  Ile Val Gly 
    1070                 1075                 1080             


Ser Val  Val Ala Gln Ile Thr  Ala Val Asp Pro Asp  Glu Gly Pro 
    1085                 1090                 1095             


Asn Ala  His Ile Met Tyr Gln  Ile Val Glu Gly Asn  Ile Pro Glu 
    1100                 1105                 1110             


Leu Phe  Gln Met Asp Ile Phe  Ser Gly Glu Leu Thr  Ala Leu Ile 
    1115                 1120                 1125             


Asp Leu  Asp Tyr Glu Ala Arg  Gln Glu Tyr Val Ile  Val Val Gln 
    1130                 1135                 1140             


Ala Thr  Ser Ala Pro Leu Val  Ser Arg Ala Thr Val  His Val Arg 
    1145                 1150                 1155             


Leu Val  Asp Gln Asn Asp Asn  Ser Pro Val Leu Asn  Asn Phe Gln 
    1160                 1165                 1170             


Ile Leu  Phe Asn Asn Tyr Val  Ser Asn Arg Ser Asp  Thr Phe Pro 
    1175                 1180                 1185             


Ser Gly  Ile Ile Gly Arg Ile  Pro Ala Tyr Asp Pro  Asp Val Ser 
    1190                 1195                 1200             


Asp His  Leu Phe Tyr Ser Phe  Glu Arg Gly Asn Glu  Leu Gln Leu 
    1205                 1210                 1215             


Leu Val  Val Asn Gln Thr Ser  Gly Glu Leu Arg Leu  Ser Arg Lys 
    1220                 1225                 1230             


Leu Asp  Asn Asn Arg Pro Leu  Val Ala Ser Met Leu  Val Thr Val 
    1235                 1240                 1245             


Thr Asp  Gly Leu His Ser Val  Thr Ala Gln Cys Val  Leu Arg Val 
    1250                 1255                 1260             


Val Ile  Ile Thr Glu Glu Leu  Leu Ala Asn Ser Leu  Thr Val Arg 
    1265                 1270                 1275             


Leu Glu  Asn Met Trp Gln Glu  Arg Phe Leu Ser Pro  Leu Leu Gly 
    1280                 1285                 1290             


Arg Phe  Leu Glu Gly Val Ala  Ala Val Leu Ala Thr  Pro Ala Glu 
    1295                 1300                 1305             


Asp Val  Phe Ile Phe Asn Ile  Gln Asn Asp Thr Asp  Val Gly Gly 
    1310                 1315                 1320             


Thr Val  Leu Asn Val Ser Phe  Ser Ala Leu Ala Pro  Arg Gly Ala 
    1325                 1330                 1335             


Gly Ala  Gly Ala Ala Gly Pro  Trp Phe Ser Ser Glu  Glu Leu Gln 
    1340                 1345                 1350             


Glu Gln  Leu Tyr Val Arg Arg  Ala Ala Leu Ala Ala  Arg Ser Leu 
    1355                 1360                 1365             


Leu Asp  Val Leu Pro Phe Asp  Asp Asn Val Cys Leu  Arg Glu Pro 
    1370                 1375                 1380             


Cys Glu  Asn Tyr Met Lys Cys  Val Ser Val Leu Arg  Phe Asp Ser 
    1385                 1390                 1395             


Ser Ala  Pro Phe Leu Ala Ser  Ala Ser Thr Leu Phe  Arg Pro Ile 
    1400                 1405                 1410             


Gln Pro  Ile Ala Gly Leu Arg  Cys Arg Cys Pro Pro  Gly Phe Thr 
    1415                 1420                 1425             


Gly Asp  Phe Cys Glu Thr Glu  Leu Asp Leu Cys Tyr  Ser Asn Pro 
    1430                 1435                 1440             


Cys Arg  Asn Gly Gly Ala Cys  Ala Arg Arg Glu Gly  Gly Tyr Thr 
    1445                 1450                 1455             


Cys Val  Cys Arg Pro Arg Phe  Thr Gly Glu Asp Cys  Glu Leu Asp 
    1460                 1465                 1470             


Thr Glu  Ala Gly Arg Cys Val  Pro Gly Val Cys Arg  Asn Gly Gly 
    1475                 1480                 1485             


Thr Cys  Thr Asp Ala Pro Asn  Gly Gly Phe Arg Cys  Gln Cys Pro 
    1490                 1495                 1500             


Ala Gly  Gly Ala Phe Glu Gly  Pro Arg Cys Glu Val  Ala Ala Arg 
    1505                 1510                 1515             


Ser Phe  Pro Pro Ser Ser Phe  Val Met Phe Arg Gly  Leu Arg Gln 
    1520                 1525                 1530             


Arg Phe  His Leu Thr Leu Ser  Leu Ser Phe Ala Thr  Val Gln Gln 
    1535                 1540                 1545             


Ser Gly  Leu Leu Phe Tyr Asn  Gly Arg Leu Asn Glu  Lys His Asp 
    1550                 1555                 1560             


Phe Leu  Ala Leu Glu Leu Val  Ala Gly Gln Val Arg  Leu Thr Tyr 
    1565                 1570                 1575             


Ser Thr  Gly Glu Ser Asn Thr  Val Val Ser Pro Thr  Val Pro Gly 
    1580                 1585                 1590             


Gly Leu  Ser Asp Gly Gln Trp  His Thr Val His Leu  Arg Tyr Tyr 
    1595                 1600                 1605             


Asn Lys  Pro Arg Thr Asp Ala  Leu Gly Gly Ala Gln  Gly Pro Ser 
    1610                 1615                 1620             


Lys Asp  Lys Val Ala Val Leu  Ser Val Asp Asp Cys  Asp Val Ala 
    1625                 1630                 1635             


Val Ala  Leu Gln Phe Gly Ala  Glu Ile Gly Asn Tyr  Ser Cys Ala 
    1640                 1645                 1650             


Ala Ala  Gly Val Gln Thr Ser  Ser Lys Lys Ser Leu  Asp Leu Thr 
    1655                 1660                 1665             


Gly Pro  Leu Leu Leu Gly Gly  Val Pro Asn Leu Pro  Glu Asn Phe 
    1670                 1675                 1680             


Pro Val  Ser His Lys Asp Phe  Ile Gly Cys Met Arg  Asp Leu His 
    1685                 1690                 1695             


Ile Asp  Gly Arg Arg Val Asp  Met Ala Ala Phe Val  Ala Asn Asn 
    1700                 1705                 1710             


Gly Thr  Met Ala Gly Cys Gln  Ala Lys Leu His Phe  Cys Asp Ser 
    1715                 1720                 1725             


Gly Pro  Cys Lys Asn Ser Gly  Phe Cys Ser Glu Arg  Trp Gly Ser 
    1730                 1735                 1740             


Phe Ser  Cys Asp Cys Pro Val  Gly Phe Gly Gly Lys  Asp Cys Gln 
    1745                 1750                 1755             


Leu Thr  Met Ala His Pro His  His Phe Arg Gly Asn  Gly Thr Leu 
    1760                 1765                 1770             


Ser Trp  Asn Phe Gly Ser Asp  Met Ala Val Ser Val  Pro Trp Tyr 
    1775                 1780                 1785             


Leu Gly  Leu Ala Phe Arg Thr  Arg Ala Thr Gln Gly  Val Leu Met 
    1790                 1795                 1800             


Gln Val  Gln Ala Gly Pro His  Ser Thr Leu Leu Cys  Gln Leu Asp 
    1805                 1810                 1815             


Arg Gly  Leu Leu Ser Val Thr  Val Thr Arg Gly Ser  Gly Arg Ala 
    1820                 1825                 1830             


Ser His  Leu Leu Leu Asp Gln  Val Thr Val Ser Asp  Gly Arg Trp 
    1835                 1840                 1845             


His Asp  Leu Arg Leu Glu Leu  Gln Glu Glu Pro Gly  Gly Arg Arg 
    1850                 1855                 1860             


Gly His  His Val Leu Met Val  Ser Leu Asp Phe Ser  Leu Phe Gln 
    1865                 1870                 1875             


Asp Thr  Met Ala Val Gly Ser  Glu Leu Gln Gly Leu  Lys Val Lys 
    1880                 1885                 1890             


Gln Leu  His Val Gly Gly Leu  Pro Pro Gly Ser Ala  Glu Glu Ala 
    1895                 1900                 1905             


Pro Gln  Gly Leu Val Gly Cys  Ile Gln Gly Val Trp  Leu Gly Ser 
    1910                 1915                 1920             


Thr Pro  Ser Gly Ser Pro Ala  Leu Leu Pro Pro Ser  His Arg Val 
    1925                 1930                 1935             


Asn Ala  Glu Pro Gly Cys Val  Val Thr Asn Ala Cys  Ala Ser Gly 
    1940                 1945                 1950             


Pro Cys  Pro Pro His Ala Asp  Cys Arg Asp Leu Trp  Gln Thr Phe 
    1955                 1960                 1965             


Ser Cys  Thr Cys Gln Pro Gly  Tyr Tyr Gly Pro Gly  Cys Val Asp 
    1970                 1975                 1980             


Ala Cys  Leu Leu Asn Pro Cys  Gln Asn Gln Gly Ser  Cys Arg His 
    1985                 1990                 1995             


Leu Pro  Gly Ala Pro His Gly  Tyr Thr Cys Asp Cys  Val Gly Gly 
    2000                 2005                 2010             


Tyr Phe  Gly His His Cys Glu  His Arg Met Asp Gln  Gln Cys Pro 
    2015                 2020                 2025             


Arg Gly  Trp Trp Gly Ser Pro  Thr Cys Gly Pro Cys  Asn Cys Asp 
    2030                 2035                 2040             


Val His  Lys Gly Phe Asp Pro  Asn Cys Asn Lys Thr  Asn Gly Gln 
    2045                 2050                 2055             


Cys His  Cys Lys Glu Phe His  Tyr Arg Pro Arg Gly  Ser Asp Ser 
    2060                 2065                 2070             


Cys Leu  Pro Cys Asp Cys Tyr  Pro Val Gly Ser Thr  Ser Arg Ser 
    2075                 2080                 2085             


Cys Ala  Pro His Ser Gly Gln  Cys Pro Cys Arg Pro  Gly Ala Leu 
    2090                 2095                 2100             


Gly Arg  Gln Cys Asn Ser Cys  Asp Ser Pro Phe Ala  Glu Val Thr 
    2105                 2110                 2115             


Ala Ser  Gly Cys Arg Val Leu  Tyr Asp Ala Cys Pro  Lys Ser Leu 
    2120                 2125                 2130             


Arg Ser  Gly Val Trp Trp Pro  Gln Thr Lys Phe Gly  Val Leu Ala 
    2135                 2140                 2145             


Thr Val  Pro Cys Pro Arg Gly  Ala Leu Gly Ala Ala  Val Arg Leu 
    2150                 2155                 2160             


Cys Asp  Glu Ala Gln Gly Trp  Leu Glu Pro Asp Leu  Phe Asn Cys 
    2165                 2170                 2175             


Thr Ser  Pro Ala Phe Arg Glu  Leu Ser Leu Leu Leu  Asp Gly Leu 
    2180                 2185                 2190             


Glu Leu  Asn Lys Thr Ala Leu  Asp Thr Met Glu Ala  Lys Lys Leu 
    2195                 2200                 2205             


Ala Gln  Arg Leu Arg Glu Val  Thr Gly His Thr Asp  His Tyr Phe 
    2210                 2215                 2220             


Ser Gln  Asp Val Arg Val Thr  Ala Arg Leu Leu Ala  His Leu Leu 
    2225                 2230                 2235             


Ala Phe  Glu Ser His Gln Gln  Gly Phe Gly Leu Thr  Ala Thr Gln 
    2240                 2245                 2250             


Asp Ala  His Phe Asn Glu Asn  Leu Leu Trp Ala Gly  Ser Ala Leu 
    2255                 2260                 2265             


Leu Ala  Pro Glu Thr Gly Asp  Leu Trp Ala Ala Leu  Gly Gln Arg 
    2270                 2275                 2280             


Ala Pro  Gly Gly Ser Pro Gly  Ser Ala Gly Leu Val  Arg His Leu 
    2285                 2290                 2295             


Glu Glu  Tyr Ala Ala Thr Leu  Ala Arg Asn Met Glu  Leu Thr Tyr 
    2300                 2305                 2310             


Leu Asn  Pro Met Gly Leu Val  Thr Pro Asn Ile Met  Leu Ser Ile 
    2315                 2320                 2325             


Asp Arg  Met Glu His Pro Ser  Ser Pro Arg Gly Ala  Arg Arg Tyr 
    2330                 2335                 2340             


Pro Arg  Tyr His Ser Asn Leu  Phe Arg Gly Gln Asp  Ala Trp Asp 
    2345                 2350                 2355             


Pro His  Thr His Val Leu Leu  Pro Ser Gln Ser Pro  Arg Pro Ser 
    2360                 2365                 2370             


Pro Ser  Glu Val Leu Pro Thr  Ser Ser Ser Ile Glu  Asn Ser Thr 
    2375                 2380                 2385             


Thr Ser  Ser Val Val Pro Pro  Pro Ala Pro Pro Glu  Pro Glu Pro 
    2390                 2395                 2400             


Gly Ile  Ser Ile Ile Ile Leu  Leu Val Tyr Arg Thr  Leu Gly Gly 
    2405                 2410                 2415             


Leu Leu  Pro Ala Gln Phe Gln  Ala Glu Arg Arg Gly  Ala Arg Leu 
    2420                 2425                 2430             


Pro Gln  Asn Pro Val Met Asn  Ser Pro Val Val Ser  Val Ala Val 
    2435                 2440                 2445             


Phe His  Gly Arg Asn Phe Leu  Arg Gly Ile Leu Glu  Ser Pro Ile 
    2450                 2455                 2460             


Ser Leu  Glu Phe Arg Leu Leu  Gln Thr Ala Asn Arg  Ser Lys Ala 
    2465                 2470                 2475             


Ile Cys  Val Gln Trp Asp Pro  Pro Gly Leu Ala Glu  Gln His Gly 
    2480                 2485                 2490             


Val Trp  Thr Ala Arg Asp Cys  Glu Leu Val His Arg  Asn Gly Ser 
    2495                 2500                 2505             


His Ala  Arg Cys Arg Cys Ser  Arg Thr Gly Thr Phe  Gly Val Leu 
    2510                 2515                 2520             


Met Asp  Ala Ser Pro Arg Glu  Arg Leu Glu Gly Asp  Leu Glu Leu 
    2525                 2530                 2535             


Leu Ala  Val Phe Thr His Val  Val Val Ala Val Ser  Val Ala Ala 
    2540                 2545                 2550             


Leu Val  Leu Thr Ala Ala Ile  Leu Leu Ser Leu Arg  Ser Leu Lys 
    2555                 2560                 2565             


Ser Asn  Val Arg Gly Ile His  Ala Asn Val Ala Ala  Ala Leu Gly 
    2570                 2575                 2580             


Val Ala  Glu Leu Leu Phe Leu  Leu Gly Ile His Arg  Thr His Asn 
    2585                 2590                 2595             


Gln Leu  Val Cys Thr Ala Val  Ala Ile Leu Leu His  Tyr Phe Phe 
    2600                 2605                 2610             


Leu Ser  Thr Phe Ala Trp Leu  Phe Val Gln Gly Leu  His Leu Tyr 
    2615                 2620                 2625             


Arg Met  Gln Val Glu Pro Arg  Asn Val Asp Arg Gly  Ala Met Arg 
    2630                 2635                 2640             


Phe Tyr  His Ala Leu Gly Trp  Gly Val Pro Ala Val  Leu Leu Gly 
    2645                 2650                 2655             


Leu Ala  Val Gly Leu Asp Pro  Glu Gly Tyr Gly Asn  Pro Asp Phe 
    2660                 2665                 2670             


Cys Trp  Ile Ser Val His Glu  Pro Leu Ile Trp Ser  Phe Ala Gly 
    2675                 2680                 2685             


Pro Val  Val Leu Val Ile Val  Met Asn Gly Thr Met  Phe Leu Leu 
    2690                 2695                 2700             


Ala Ala  Arg Thr Ser Cys Ser  Thr Gly Gln Arg Glu  Ala Lys Lys 
    2705                 2710                 2715             


Thr Ser  Ala Leu Thr Leu Arg  Ser Ser Phe Leu Leu  Leu Leu Leu 
    2720                 2725                 2730             


Val Ser  Ala Ser Trp Leu Phe  Gly Leu Leu Ala Val  Asn His Ser 
    2735                 2740                 2745             


Ile Leu  Ala Phe His Tyr Leu  His Ala Gly Leu Cys  Gly Leu Gln 
    2750                 2755                 2760             


Gly Leu  Ala Val Leu Leu Leu  Phe Cys Val Leu Asn  Ala Asp Ala 
    2765                 2770                 2775             


Arg Ala  Ala Trp Met Pro Ala  Cys Leu Gly Arg Lys  Ala Ala Pro 
    2780                 2785                 2790             


Glu Glu  Ala Arg Pro Ala Pro  Gly Leu Gly Pro Gly  Ala Tyr Asn 
    2795                 2800                 2805             


Asn Thr  Ala Leu Phe Glu Glu  Ser Gly Leu Ile Arg  Ile Thr Leu 
    2810                 2815                 2820             


Gly Ala  Ser Thr Val Ser Ser  Val Ser Ser Ala Arg  Ser Gly Arg 
    2825                 2830                 2835             


Thr Gln  Asp Gln Asp Ser Gln  Arg Gly Arg Ser Tyr  Leu Arg Asp 
    2840                 2845                 2850             


Asn Val  Leu Val Arg His Gly  Ser Ala Ala Asp His  Thr Asp His 
    2855                 2860                 2865             


Ser Leu  Gln Ala His Ala Gly  Pro Thr Asp Leu Asp  Val Ala Met 
    2870                 2875                 2880             


Phe His  Arg Asp Ala Gly Ala  Asp Ser Asp Ser Asp  Ser Asp Leu 
    2885                 2890                 2895             


Ser Leu  Glu Glu Glu Arg Ser  Leu Ser Ile Pro Ser  Ser Glu Ser 
    2900                 2905                 2910             


Glu Asp  Asn Gly Arg Thr Arg  Gly Arg Phe Gln Arg  Pro Leu Cys 
    2915                 2920                 2925             


Arg Ala  Ala Gln Ser Glu Arg  Leu Leu Thr His Pro  Lys Asp Val 
    2930                 2935                 2940             


Asp Gly  Asn Asp Leu Leu Ser  Tyr Trp Pro Ala Leu  Gly Glu Cys 
    2945                 2950                 2955             


Glu Ala  Ala Pro Cys Ala Leu  Gln Thr Trp Gly Ser  Glu Arg Arg 
    2960                 2965                 2970             


Leu Gly  Leu Asp Thr Ser Lys  Asp Ala Ala Asn Asn  Asn Gln Pro 
    2975                 2980                 2985             


Asp Pro  Ala Leu Thr Ser Gly  Asp Glu Thr Ser Leu  Gly Arg Ala 
    2990                 2995                 3000             


Gln Arg  Gln Arg Lys Gly Ile  Leu Lys Asn Arg Leu  Gln Tyr Pro 
    3005                 3010                 3015             


Leu Val  Pro Gln Thr Arg Gly  Ala Pro Glu Leu Ser  Trp Cys Arg 
    3020                 3025                 3030             


Ala Ala  Thr Leu Gly His Arg  Ala Val Pro Ala Ala  Ser Tyr Gly 
    3035                 3040                 3045             


Arg Ile  Tyr Ala Gly Gly Gly  Thr Gly Ser Leu Ser  Gln Pro Ala 
    3050                 3055                 3060             


Ser Arg  Tyr Ser Ser Arg Glu  Gln Leu Asp Leu Leu  Leu Arg Arg 
    3065                 3070                 3075             


Gln Leu  Ser Arg Glu Arg Leu  Glu Glu Ala Pro Ala  Pro Val Leu 
    3080                 3085                 3090             


Arg Pro  Leu Ser Arg Pro Gly  Ser Gln Glu Cys Met  Asp Ala Ala 
    3095                 3100                 3105             


Pro Gly  Arg Leu Glu Pro Lys  Asp Arg Gly Ser Thr  Leu Pro Arg 
    3110                 3115                 3120             


Arg Gln  Pro Pro Arg Asp Tyr  Pro Gly Ala Met Ala  Gly Arg Phe 
    3125                 3130                 3135             


Gly Ser  Arg Asp Ala Leu Asp  Leu Gly Ala Pro Arg  Glu Trp Leu 
    3140                 3145                 3150             


Ser Thr  Leu Pro Pro Pro Arg  Arg Thr Arg Asp Leu  Asp Pro Gln 
    3155                 3160                 3165             


Pro Pro  Pro Leu Pro Leu Ser  Pro Gln Arg Gln Leu  Ser Arg Asp 
    3170                 3175                 3180             


Pro Leu  Leu Pro Ser Arg Pro  Leu Asp Ser Leu Ser  Arg Ser Ser 
    3185                 3190                 3195             


Asn Ser  Arg Glu Gln Leu Asp  Gln Val Pro Ser Arg  His Pro Ser 
    3200                 3205                 3210             


Arg Glu  Ala Leu Gly Pro Leu  Pro Gln Leu Leu Arg  Ala Arg Glu 
    3215                 3220                 3225             


Asp Ser  Val Ser Gly Pro Ser  His Gly Pro Ser Thr  Glu Gln Leu 
    3230                 3235                 3240             


Asp Ile  Leu Ser Ser Ile Leu  Ala Ser Phe Asn Ser  Ser Ala Leu 
    3245                 3250                 3255             


Ser Ser  Val Gln Ser Ser Ser  Thr Pro Leu Gly Pro  His Thr Thr 
    3260                 3265                 3270             


Ala Thr  Pro Ser Ala Thr Ala  Ser Val Leu Gly Pro  Ser Thr Pro 
    3275                 3280                 3285             


Arg Ser  Ala Thr Ser His Ser  Ile Ser Glu Leu Ser  Pro Asp Ser 
    3290                 3295                 3300             


Glu Val  Pro Arg Ser Glu Gly  His Ser 
    3305                 3310         


<210>  5705
<211>  663
<212>  PRT
<213>  Homo sapiens

<400>  5705

Met Thr Gly Ala Lys Arg Lys Lys Lys Ser Met Leu Trp Ser Lys Met 
1               5                   10                  15      


His Thr Pro Gln Cys Glu Asp Ile Ile Gln Trp Cys Arg Arg Arg Leu 
            20                  25                  30          


Pro Ile Leu Asp Trp Ala Pro His Tyr Asn Leu Lys Glu Asn Leu Leu 
        35                  40                  45              


Pro Asp Thr Val Ser Gly Ile Met Leu Ala Val Gln Gln Val Thr Gln 
    50                  55                  60                  


Gly Leu Ala Phe Ala Val Leu Ser Ser Val His Pro Val Phe Gly Leu 
65                  70                  75                  80  


Tyr Gly Ser Leu Phe Pro Ala Ile Ile Tyr Ala Ile Phe Gly Met Gly 
                85                  90                  95      


His His Val Ala Thr Gly Thr Phe Ala Leu Thr Ser Leu Ile Ser Ala 
            100                 105                 110         


Asn Ala Val Glu Arg Ile Val Pro Gln Asn Met Gln Asn Leu Thr Thr 
        115                 120                 125             


Gln Ser Asn Thr Ser Val Leu Gly Leu Ser Asp Phe Glu Met Gln Arg 
    130                 135                 140                 


Ile His Val Ala Ala Ala Val Ser Phe Leu Gly Gly Val Ile Gln Val 
145                 150                 155                 160 


Ala Met Phe Val Leu Gln Leu Gly Ser Ala Thr Phe Val Val Thr Glu 
                165                 170                 175     


Pro Val Ile Ser Ala Met Thr Thr Gly Ala Ala Thr His Val Val Thr 
            180                 185                 190         


Ser Gln Val Lys Tyr Leu Leu Gly Met Lys Met Pro Tyr Ile Ser Gly 
        195                 200                 205             


Pro Leu Gly Phe Phe Tyr Ile Tyr Ala Tyr Val Phe Glu Asn Ile Lys 
    210                 215                 220                 


Ser Val Arg Leu Glu Ala Leu Leu Leu Ser Leu Leu Ser Ile Val Val 
225                 230                 235                 240 


Leu Val Leu Val Lys Glu Leu Asn Glu Gln Phe Lys Arg Lys Ile Lys 
                245                 250                 255     


Val Val Leu Pro Val Asp Leu Val Leu Ile Ile Ala Ala Ser Phe Ala 
            260                 265                 270         


Cys Tyr Cys Thr Asn Met Glu Asn Thr Tyr Gly Leu Glu Val Val Gly 
        275                 280                 285             


His Ile Pro Gln Gly Ile Pro Ser Pro Arg Ala Pro Pro Met Asn Ile 
    290                 295                 300                 


Leu Ser Ala Val Ile Thr Glu Ala Phe Gly Val Ala Leu Val Gly Tyr 
305                 310                 315                 320 


Val Ala Ser Leu Ala Leu Ala Gln Gly Ser Ala Lys Lys Phe Lys Tyr 
                325                 330                 335     


Ser Ile Asp Asp Asn Gln Glu Phe Leu Ala His Gly Leu Ser Asn Ile 
            340                 345                 350         


Val Ser Ser Phe Phe Phe Cys Ile Pro Ser Ala Ala Ala Met Gly Arg 
        355                 360                 365             


Thr Ala Gly Leu Tyr Ser Thr Gly Ala Lys Thr Gln Val Ala Cys Leu 
    370                 375                 380                 


Ile Ser Cys Ile Phe Val Leu Ile Val Ile Tyr Ala Ile Gly Pro Leu 
385                 390                 395                 400 


Leu Tyr Trp Leu Pro Met Cys Val Leu Ala Ser Ile Ile Val Val Gly 
                405                 410                 415     


Leu Lys Gly Met Leu Ile Gln Phe Arg Asp Leu Lys Lys Tyr Trp Asn 
            420                 425                 430         


Val Asp Lys Ile Asp Trp Gly Ile Trp Val Ser Thr Tyr Val Phe Thr 
        435                 440                 445             


Ile Cys Phe Ala Ala Asn Val Gly Leu Leu Phe Gly Val Val Cys Thr 
    450                 455                 460                 


Ile Ala Ile Val Ile Gly Arg Phe Pro Arg Ala Met Thr Val Ser Ile 
465                 470                 475                 480 


Lys Asn Met Lys Glu Met Glu Phe Lys Val Lys Thr Glu Met Asp Ser 
                485                 490                 495     


Glu Thr Leu Gln Gln Val Lys Ile Ile Ser Ile Asn Asn Pro Leu Val 
            500                 505                 510         


Phe Leu Asn Ala Lys Lys Phe Tyr Thr Asp Leu Met Asn Met Ile Gln 
        515                 520                 525             


Lys Glu Asn Ala Cys Asn Gln Pro Leu Asp Asp Ile Ser Lys Cys Glu 
    530                 535                 540                 


Gln Asn Thr Leu Leu Asn Ser Leu Ser Asn Gly Asn Cys Asn Glu Glu 
545                 550                 555                 560 


Ala Ser Gln Ser Cys Pro Asn Glu Lys Cys Tyr Leu Ile Leu Asp Cys 
                565                 570                 575     


Ser Gly Phe Thr Phe Phe Asp Tyr Ser Gly Val Ser Met Leu Val Glu 
            580                 585                 590         


Val Tyr Met Asp Cys Lys Gly Arg Ser Val Asp Val Leu Leu Ala His 
        595                 600                 605             


Cys Thr Ala Ser Leu Ile Lys Ala Met Thr Tyr Tyr Gly Asn Leu Asp 
    610                 615                 620                 


Ser Glu Lys Pro Ile Phe Phe Glu Ser Val Ser Ala Ala Ile Ser His 
625                 630                 635                 640 


Ile His Ser Asn Lys Ala Ser Tyr Lys Leu Leu Phe Asp Asn Leu Asp 
                645                 650                 655     


Leu Pro Thr Met Pro Pro Leu 
            660             


<210>  5706
<211>  887
<212>  PRT
<213>  Homo sapiens

<400>  5706

Met Ser Gln Pro Arg Pro Arg Tyr Val Val Asp Arg Ala Ala Tyr Ser 
1               5                   10                  15      


Leu Thr Leu Phe Asp Asp Glu Phe Glu Lys Lys Asp Arg Thr Tyr Pro 
            20                  25                  30          


Val Gly Glu Lys Leu Arg Asn Ala Phe Arg Cys Ser Ser Ala Lys Ile 
        35                  40                  45              


Lys Ala Val Val Phe Gly Leu Leu Pro Val Leu Ser Trp Leu Pro Lys 
    50                  55                  60                  


Tyr Lys Ile Lys Asp Tyr Ile Ile Pro Asp Leu Leu Gly Gly Leu Ser 
65                  70                  75                  80  


Gly Gly Ser Ile Gln Val Pro Gln Gly Met Ala Phe Ala Leu Leu Ala 
                85                  90                  95      


Asn Leu Pro Ala Val Asn Gly Leu Tyr Ser Ser Phe Phe Pro Leu Leu 
            100                 105                 110         


Thr Tyr Phe Phe Leu Gly Gly Val His Gln Met Val Pro Gly Thr Phe 
        115                 120                 125             


Ala Val Ile Ser Ile Leu Val Gly Asn Ile Cys Leu Gln Leu Ala Pro 
    130                 135                 140                 


Glu Ser Lys Phe Gln Val Phe Asn Asn Ala Thr Asn Glu Ser Tyr Val 
145                 150                 155                 160 


Asp Thr Ala Ala Met Glu Ala Glu Arg Leu His Val Ser Ala Thr Leu 
                165                 170                 175     


Ala Cys Leu Thr Ala Ile Ile Gln Met Gly Leu Gly Phe Met Gln Phe 
            180                 185                 190         


Gly Phe Val Ala Ile Tyr Leu Ser Glu Ser Phe Ile Arg Gly Phe Met 
        195                 200                 205             


Thr Ala Ala Gly Leu Gln Ile Leu Ile Ser Val Leu Lys Tyr Ile Phe 
    210                 215                 220                 


Gly Leu Thr Ile Pro Ser Tyr Thr Gly Pro Gly Ser Ile Val Phe Thr 
225                 230                 235                 240 


Phe Ile Asp Ile Cys Lys Asn Leu Pro His Thr Asn Ile Ala Ser Leu 
                245                 250                 255     


Ile Phe Ala Leu Ile Ser Gly Ala Phe Leu Val Leu Val Lys Glu Leu 
            260                 265                 270         


Asn Ala Arg Tyr Met His Lys Ile Arg Phe Pro Ile Pro Thr Glu Met 
        275                 280                 285             


Ile Val Val Val Val Ala Thr Ala Ile Ser Gly Gly Cys Lys Met Pro 
    290                 295                 300                 


Lys Lys Tyr His Met Gln Ile Val Gly Glu Ile Gln Arg Gly Phe Pro 
305                 310                 315                 320 


Thr Pro Val Ser Pro Val Val Ser Gln Trp Lys Asp Met Ile Gly Thr 
                325                 330                 335     


Ala Phe Ser Leu Ala Ile Val Ser Tyr Val Ile Asn Leu Ala Met Gly 
            340                 345                 350         


Arg Thr Leu Ala Asn Lys His Gly Tyr Asp Val Asp Ser Asn Gln Glu 
        355                 360                 365             


Met Ile Ala Leu Gly Cys Ser Asn Phe Phe Gly Ser Phe Phe Lys Ile 
    370                 375                 380                 


His Val Ile Cys Cys Ala Leu Ser Val Thr Leu Ala Val Asp Gly Ala 
385                 390                 395                 400 


Gly Gly Lys Ser Gln Val Ala Ser Leu Cys Val Ser Leu Val Val Met 
                405                 410                 415     


Ile Thr Met Leu Val Leu Gly Ile Tyr Leu Tyr Pro Leu Pro Lys Ser 
            420                 425                 430         


Val Leu Gly Ala Leu Ile Ala Val Asn Leu Lys Asn Ser Leu Lys Gln 
        435                 440                 445             


Leu Thr Asp Pro Tyr Tyr Leu Trp Arg Lys Ser Lys Leu Asp Cys Cys 
    450                 455                 460                 


Ile Trp Val Val Ser Phe Leu Ser Ser Phe Phe Leu Ser Leu Pro Tyr 
465                 470                 475                 480 


Gly Val Ala Val Gly Val Ala Phe Ser Val Leu Val Val Val Phe Gln 
                485                 490                 495     


Thr Gln Phe Arg Asn Gly Tyr Ala Leu Ala Gln Val Met Asp Thr Asp 
            500                 505                 510         


Ile Tyr Val Asn Pro Lys Thr Tyr Asn Arg Ala Gln Asp Ile Gln Gly 
        515                 520                 525             


Ile Lys Ile Ile Thr Tyr Cys Ser Pro Leu Tyr Phe Ala Asn Ser Glu 
    530                 535                 540                 


Ile Phe Arg Gln Lys Val Ile Ala Lys Thr Gly Met Asp Pro Gln Lys 
545                 550                 555                 560 


Val Leu Leu Ala Lys Gln Lys Tyr Leu Lys Lys Gln Glu Lys Arg Arg 
                565                 570                 575     


Met Arg Pro Thr Gln Gln Arg Arg Ser Leu Phe Met Lys Thr Lys Thr 
            580                 585                 590         


Val Ser Leu Gln Glu Leu Gln Gln Asp Phe Glu Asn Ala Pro Pro Thr 
        595                 600                 605             


Asp Pro Asn Asn Asn Gln Thr Pro Ala Asn Gly Thr Ser Val Ser Tyr 
    610                 615                 620                 


Ile Thr Phe Ser Pro Asp Ser Ser Ser Pro Ala Gln Ser Glu Pro Pro 
625                 630                 635                 640 


Ala Ser Ala Glu Ala Pro Gly Glu Pro Ser Asp Met Leu Ala Ser Val 
                645                 650                 655     


Pro Pro Phe Val Thr Phe His Thr Leu Ile Leu Asp Met Ser Gly Val 
            660                 665                 670         


Ser Phe Val Asp Leu Met Gly Ile Lys Ala Leu Ala Lys Leu Ser Ser 
        675                 680                 685             


Thr Tyr Gly Lys Ile Gly Val Lys Val Phe Leu Val Asn Ile His Ala 
    690                 695                 700                 


Gln Val Tyr Asn Asp Ile Ser His Gly Gly Val Phe Glu Asp Gly Ser 
705                 710                 715                 720 


Leu Glu Cys Lys His Val Phe Pro Ser Ile His Asp Ala Val Leu Phe 
                725                 730                 735     


Ala Gln Ala Asn Ala Arg Asp Val Thr Pro Gly His Asn Phe Gln Gly 
            740                 745                 750         


Ala Pro Gly Asp Ala Glu Leu Ser Leu Tyr Asp Ser Glu Glu Asp Ile 
        755                 760                 765             


Arg Ser Tyr Trp Asp Leu Glu Gln Glu Met Phe Gly Ser Met Phe His 
    770                 775                 780                 


Ala Glu Thr Leu Thr Ala Leu Glu Ser Leu Ser Ala Ala Gly Gly Cys 
785                 790                 795                 800 


Tyr Pro Tyr Arg Ser Glu Ser Leu Val Ser Pro Leu Phe Thr Arg Gln 
                805                 810                 815     


Ala Leu Ala Ala Met Asp Lys Pro Pro Ala His Ser Thr Pro Pro Thr 
            820                 825                 830         


Ser Ala Leu Ser Leu Ala Ala Glu Gly His Leu Asp Phe Gln Leu Leu 
        835                 840                 845             


Arg Val Ser Gln Lys Gln Lys Asp Lys Tyr Asn Cys Ala Gly Leu Leu 
    850                 855                 860                 


Tyr Lys Leu Gln Lys Val Ser Gln Ser Pro His Gly Ser Val Ser Asp 
865                 870                 875                 880 


Gly Val Arg Leu Ser Arg Thr 
                885         


<210>  5707
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  5707

Met Asp Glu Ser Pro Glu Pro Leu Gln Gln Gly Arg Gly Pro Val Pro 
1               5                   10                  15      


Val Arg Arg Gln Arg Pro Ala Pro Arg Gly Leu Arg Glu Met Leu Lys 
            20                  25                  30          


Ala Arg Leu Trp Cys Ser Cys Ser Cys Ser Val Leu Cys Val Arg Ala 
        35                  40                  45              


Leu Val Gln Asp Leu Leu Pro Ala Thr Arg Trp Leu Arg Gln Tyr Arg 
    50                  55                  60                  


Pro Arg Glu Tyr Leu Ala Gly Asp Val Met Ser Gly Leu Val Ile Gly 
65                  70                  75                  80  


Ile Ile Leu Val Pro Gln Ala Ile Ala Tyr Ser Leu Leu Ala Gly Leu 
                85                  90                  95      


Gln Pro Ile Tyr Ser Leu Tyr Thr Ser Phe Phe Ala Asn Leu Ile Tyr 
            100                 105                 110         


Phe Leu Met Gly Thr Ser Arg His Val Ser Val Gly Ile Phe Ser Leu 
        115                 120                 125             


Leu Cys Leu Met Val Gly Gln Val Val Asp Arg Glu Leu Gln Leu Ala 
    130                 135                 140                 


Gly Phe Asp Pro Ser Gln Asp Gly Leu Gln Pro Gly Ala Asn Ser Ser 
145                 150                 155                 160 


Thr Leu Asn Gly Ser Ala Ala Met Leu Asp Cys Gly Arg Asp Cys Tyr 
                165                 170                 175     


Ala Ile Arg Val Ala Thr Ala Leu Thr Leu Met Thr Gly Leu Tyr Gln 
            180                 185                 190         


Thr Ser Trp Gly Arg Asn Ser Phe Gln Gln His Pro Trp Gln Leu Thr 
        195                 200                 205             


Gln Arg Ser Asp Ser Gln Glu Leu Leu Glu Glu Glu Glu Arg Ser Cys 
    210                 215                 220                 


<210>  5708
<211>  740
<212>  PRT
<213>  Homo sapiens

<400>  5708

Met Gly Leu Ala Asp Ala Ser Gly Pro Arg Asp Thr Gln Ala Leu Leu 
1               5                   10                  15      


Ser Ala Thr Gln Ala Met Asp Leu Arg Arg Arg Asp Tyr His Met Glu 
            20                  25                  30          


Arg Pro Leu Leu Asn Gln Glu His Leu Glu Glu Leu Gly Arg Trp Gly 
        35                  40                  45              


Ser Ala Pro Arg Thr His Gln Trp Arg Thr Trp Leu Gln Cys Ser Arg 
    50                  55                  60                  


Ala Arg Ala Tyr Ala Leu Leu Leu Gln His Leu Pro Val Leu Val Trp 
65                  70                  75                  80  


Leu Pro Arg Tyr Pro Val Arg Asp Trp Leu Leu Gly Asp Leu Leu Ser 
                85                  90                  95      


Gly Leu Ser Val Ala Ile Met Gln Leu Pro Gln Gly Leu Ala Tyr Ala 
            100                 105                 110         


Leu Leu Ala Gly Leu Pro Pro Val Phe Gly Leu Tyr Ser Ser Phe Tyr 
        115                 120                 125             


Pro Val Phe Ile Tyr Phe Leu Phe Gly Thr Ser Arg His Ile Ser Val 
    130                 135                 140                 


Gly Thr Phe Ala Val Met Ser Val Met Val Gly Ser Val Thr Glu Ser 
145                 150                 155                 160 


Leu Ala Pro Gln Ala Leu Asn Asp Ser Met Ile Asn Glu Thr Ala Arg 
                165                 170                 175     


Asp Ala Ala Arg Val Gln Val Ala Ser Thr Leu Ser Val Leu Val Gly 
            180                 185                 190         


Leu Phe Gln Val Gly Leu Gly Leu Ile His Phe Gly Phe Val Val Thr 
        195                 200                 205             


Tyr Leu Ser Glu Pro Leu Val Arg Gly Tyr Thr Thr Ala Ala Ala Val 
    210                 215                 220                 


Gln Val Phe Val Ser Gln Leu Lys Tyr Val Phe Gly Leu His Leu Ser 
225                 230                 235                 240 


Ser His Ser Gly Pro Leu Ser Leu Ile Tyr Thr Val Leu Glu Val Cys 
                245                 250                 255     


Trp Lys Leu Pro Gln Ser Lys Val Gly Thr Val Val Thr Ala Ala Val 
            260                 265                 270         


Ala Gly Val Val Leu Val Val Val Lys Leu Leu Asn Asp Lys Leu Gln 
        275                 280                 285             


Gln Gln Leu Pro Met Pro Ile Pro Gly Glu Leu Leu Thr Leu Ile Gly 
    290                 295                 300                 


Ala Thr Gly Ile Ser Tyr Gly Met Gly Leu Lys His Arg Phe Glu Val 
305                 310                 315                 320 


Asp Val Val Gly Asn Ile Pro Ala Gly Leu Val Pro Pro Val Ala Pro 
                325                 330                 335     


Asn Thr Gln Leu Phe Ser Lys Leu Val Gly Ser Ala Phe Thr Ile Ala 
            340                 345                 350         


Val Val Gly Phe Ala Ile Ala Ile Ser Leu Gly Lys Ile Phe Ala Leu 
        355                 360                 365             


Arg His Gly Tyr Arg Val Asp Ser Asn Gln Glu Leu Val Ala Leu Gly 
    370                 375                 380                 


Leu Ser Asn Leu Ile Gly Gly Ile Phe Gln Cys Phe Pro Val Ser Cys 
385                 390                 395                 400 


Ser Met Ser Arg Ser Leu Val Gln Glu Ser Thr Gly Gly Asn Ser Gln 
                405                 410                 415     


Val Ala Gly Ala Ile Ser Ser Leu Phe Ile Leu Leu Ile Ile Val Lys 
            420                 425                 430         


Leu Gly Glu Leu Phe His Asp Leu Pro Lys Ala Val Leu Ala Ala Ile 
        435                 440                 445             


Ile Ile Val Asn Leu Lys Gly Met Leu Arg Gln Leu Ser Asp Met Arg 
    450                 455                 460                 


Ser Leu Trp Lys Ala Asn Arg Ala Asp Leu Leu Ile Trp Leu Val Thr 
465                 470                 475                 480 


Phe Thr Ala Thr Ile Leu Leu Asn Leu Asp Leu Gly Leu Val Val Ala 
                485                 490                 495     


Val Ile Phe Ser Leu Leu Leu Val Val Val Arg Thr Gln Met Pro His 
            500                 505                 510         


Tyr Ser Val Leu Gly Gln Val Pro Asp Thr Asp Ile Tyr Arg Asp Val 
        515                 520                 525             


Ala Glu Tyr Ser Glu Ala Lys Glu Val Arg Gly Val Lys Val Phe Arg 
    530                 535                 540                 


Ser Ser Ala Thr Val Tyr Phe Ala Asn Ala Glu Phe Tyr Ser Asp Ala 
545                 550                 555                 560 


Leu Lys Gln Arg Cys Gly Val Asp Val Asp Phe Leu Ile Ser Gln Lys 
                565                 570                 575     


Lys Lys Leu Leu Lys Lys Gln Glu Gln Leu Lys Leu Lys Gln Leu Gln 
            580                 585                 590         


Lys Glu Glu Lys Leu Arg Lys Gln Ala Gly Pro Leu Leu Ser Ala Cys 
        595                 600                 605             


Leu Ala Pro Gln Gln Val Ser Ser Gly Asp Lys Met Glu Asp Ala Thr 
    610                 615                 620                 


Ala Asn Gly Gln Glu Asp Ser Lys Ala Pro Asp Gly Ser Thr Leu Lys 
625                 630                 635                 640 


Ala Leu Gly Leu Pro Gln Pro Asp Phe His Ser Leu Ile Leu Asp Leu 
                645                 650                 655     


Gly Ala Leu Ser Phe Val Asp Thr Val Cys Leu Lys Ser Leu Lys Asn 
            660                 665                 670         


Ile Phe His Asp Phe Arg Glu Ile Glu Val Glu Val Tyr Met Ala Ala 
        675                 680                 685             


Cys His Ser Pro Val Val Ser Gln Leu Glu Ala Gly His Phe Phe Asp 
    690                 695                 700                 


Ala Ser Ile Thr Lys Lys His Leu Phe Ala Ser Val His Asp Ala Val 
705                 710                 715                 720 


Thr Phe Ala Leu Gln His Pro Arg Pro Val Pro Asp Ser Pro Val Ser 
                725                 730                 735     


Val Thr Arg Leu 
            740 


<210>  5709
<211>  3312
<212>  PRT
<213>  Homo sapiens

<400>  5709

Met Met Ala Arg Arg Pro Pro Trp Arg Gly Leu Gly Gly Arg Ser Thr 
1               5                   10                  15      


Pro Ile Leu Leu Leu Leu Leu Leu Ser Leu Phe Pro Leu Ser Gln Glu 
            20                  25                  30          


Glu Leu Gly Gly Gly Gly His Gln Gly Trp Asp Pro Gly Leu Ala Ala 
        35                  40                  45              


Thr Thr Gly Pro Arg Ala His Ile Gly Gly Gly Ala Leu Ala Leu Cys 
    50                  55                  60                  


Pro Glu Ser Ser Gly Val Arg Glu Asp Gly Gly Pro Gly Leu Gly Val 
65                  70                  75                  80  


Arg Glu Pro Ile Phe Val Gly Leu Arg Gly Arg Arg Gln Ser Ala Arg 
                85                  90                  95      


Asn Ser Arg Gly Pro Pro Glu Gln Pro Asn Glu Glu Leu Gly Ile Glu 
            100                 105                 110         


His Gly Val Gln Pro Leu Gly Ser Arg Glu Arg Glu Thr Gly Gln Gly 
        115                 120                 125             


Pro Gly Ser Val Leu Tyr Trp Arg Pro Glu Val Ser Ser Cys Gly Arg 
    130                 135                 140                 


Thr Gly Pro Leu Gln Arg Gly Ser Leu Ser Pro Gly Ala Leu Ser Ser 
145                 150                 155                 160 


Gly Val Pro Gly Ser Gly Asn Ser Ser Pro Leu Pro Ser Asp Phe Leu 
                165                 170                 175     


Ile Arg His His Gly Pro Lys Pro Val Ser Ser Gln Arg Asn Ala Gly 
            180                 185                 190         


Thr Gly Ser Arg Lys Arg Val Gly Thr Ala Arg Cys Cys Gly Glu Leu 
        195                 200                 205             


Trp Ala Thr Gly Ser Lys Gly Gln Gly Glu Arg Ala Thr Thr Ser Gly 
    210                 215                 220                 


Ala Glu Arg Thr Ala Pro Arg Arg Asn Cys Leu Pro Gly Ala Ser Gly 
225                 230                 235                 240 


Ser Gly Pro Glu Leu Asp Ser Ala Pro Arg Thr Ala Arg Thr Ala Pro 
                245                 250                 255     


Ala Ser Gly Ser Ala Pro Arg Glu Ser Arg Thr Ala Pro Glu Pro Ala 
            260                 265                 270         


Pro Lys Arg Met Arg Ser Arg Gly Leu Phe Arg Cys Arg Phe Leu Pro 
        275                 280                 285             


Gln Arg Pro Gly Pro Arg Pro Pro Gly Leu Pro Ala Arg Pro Glu Ala 
    290                 295                 300                 


Arg Lys Val Thr Ser Ala Asn Arg Ala Arg Phe Arg Arg Ala Ala Asn 
305                 310                 315                 320 


Arg His Pro Gln Phe Pro Gln Tyr Asn Tyr Gln Thr Leu Val Pro Glu 
                325                 330                 335     


Asn Glu Ala Ala Gly Thr Ala Val Leu Arg Val Val Ala Gln Asp Pro 
            340                 345                 350         


Asp Ala Gly Glu Ala Gly Arg Leu Val Tyr Ser Leu Ala Ala Leu Met 
        355                 360                 365             


Asn Ser Arg Ser Leu Glu Leu Phe Ser Ile Asp Pro Gln Ser Gly Leu 
    370                 375                 380                 


Ile Arg Thr Ala Ala Ala Leu Asp Arg Glu Ser Met Glu Arg His Tyr 
385                 390                 395                 400 


Leu Arg Val Thr Ala Gln Asp His Gly Ser Pro Arg Leu Ser Ala Thr 
                405                 410                 415     


Thr Met Val Ala Val Thr Val Ala Asp Arg Asn Asp His Ser Pro Val 
            420                 425                 430         


Phe Glu Gln Ala Gln Tyr Arg Glu Thr Leu Arg Glu Asn Val Glu Glu 
        435                 440                 445             


Gly Tyr Pro Ile Leu Gln Leu Arg Ala Thr Asp Gly Asp Ala Pro Pro 
    450                 455                 460                 


Asn Ala Asn Leu Arg Tyr Arg Phe Val Gly Pro Pro Ala Ala Arg Ala 
465                 470                 475                 480 


Ala Ala Ala Ala Ala Phe Glu Ile Asp Pro Arg Ser Gly Leu Ile Ser 
                485                 490                 495     


Thr Ser Gly Arg Val Asp Arg Glu His Met Glu Ser Tyr Glu Leu Val 
            500                 505                 510         


Val Glu Ala Ser Asp Gln Gly Gln Glu Pro Gly Pro Arg Ser Ala Thr 
        515                 520                 525             


Val Arg Val His Ile Thr Val Leu Asp Glu Asn Asp Asn Ala Pro Gln 
    530                 535                 540                 


Phe Ser Glu Lys Arg Tyr Val Ala Gln Val Arg Glu Asp Val Arg Pro 
545                 550                 555                 560 


His Thr Val Val Leu Arg Val Thr Ala Thr Asp Arg Asp Lys Asp Ala 
                565                 570                 575     


Asn Gly Leu Val His Tyr Asn Ile Ile Ser Gly Asn Ser Arg Gly His 
            580                 585                 590         


Phe Ala Ile Asp Ser Leu Thr Gly Glu Ile Gln Val Val Ala Pro Leu 
        595                 600                 605             


Asp Phe Glu Ala Glu Arg Glu Tyr Ala Leu Arg Ile Arg Ala Gln Asp 
    610                 615                 620                 


Ala Gly Arg Pro Pro Leu Ser Asn Asn Thr Gly Leu Ala Ser Ile Gln 
625                 630                 635                 640 


Val Val Asp Ile Asn Asp His Ile Pro Ile Phe Val Ser Thr Pro Phe 
                645                 650                 655     


Gln Val Ser Val Leu Glu Asn Ala Pro Leu Gly His Ser Val Ile His 
            660                 665                 670         


Ile Gln Ala Val Asp Ala Asp His Gly Glu Asn Ala Arg Leu Glu Tyr 
        675                 680                 685             


Ser Leu Thr Gly Val Ala Pro Asp Thr Pro Phe Val Ile Asn Ser Ala 
    690                 695                 700                 


Thr Gly Trp Val Ser Val Ser Gly Pro Leu Asp Arg Glu Ser Val Glu 
705                 710                 715                 720 


His Tyr Phe Phe Gly Val Glu Ala Arg Asp His Gly Ser Pro Pro Leu 
                725                 730                 735     


Ser Ala Ser Ala Ser Val Thr Val Thr Val Leu Asp Val Asn Asp Asn 
            740                 745                 750         


Arg Pro Glu Phe Thr Met Lys Glu Tyr His Leu Arg Leu Asn Glu Asp 
        755                 760                 765             


Ala Ala Val Gly Thr Ser Val Val Ser Val Thr Ala Val Asp Arg Asp 
    770                 775                 780                 


Ala Asn Ser Ala Ile Ser Tyr Gln Ile Thr Gly Gly Asn Thr Arg Asn 
785                 790                 795                 800 


Arg Phe Ala Ile Ser Thr Gln Gly Gly Val Gly Leu Val Thr Leu Ala 
                805                 810                 815     


Leu Pro Leu Asp Tyr Lys Gln Glu Arg Tyr Phe Lys Leu Val Leu Thr 
            820                 825                 830         


Ala Ser Asp Arg Ala Leu His Asp His Cys Tyr Val His Ile Asn Ile 
        835                 840                 845             


Thr Asp Ala Asn Thr His Arg Pro Val Phe Gln Ser Ala His Tyr Ser 
    850                 855                 860                 


Val Ser Val Asn Glu Asp Arg Pro Met Gly Ser Thr Ile Val Val Ile 
865                 870                 875                 880 


Ser Ala Ser Asp Asp Asp Val Gly Glu Asn Ala Arg Ile Thr Tyr Leu 
                885                 890                 895     


Leu Glu Asp Asn Leu Pro Gln Phe Arg Ile Asp Ala Asp Ser Gly Ala 
            900                 905                 910         


Ile Thr Leu Gln Ala Pro Leu Asp Tyr Glu Asp Gln Val Thr Tyr Thr 
        915                 920                 925             


Leu Ala Ile Thr Ala Arg Asp Asn Gly Ile Pro Gln Lys Ala Asp Thr 
    930                 935                 940                 


Thr Tyr Val Glu Val Met Val Asn Asp Val Asn Asp Asn Ala Pro Gln 
945                 950                 955                 960 


Phe Val Ala Ser His Tyr Thr Gly Leu Val Ser Glu Asp Ala Pro Pro 
                965                 970                 975     


Phe Thr Ser Val Leu Gln Ile Ser Ala Thr Asp Arg Asp Ala His Ala 
            980                 985                 990         


Asn Gly Arg Val Gln Tyr Thr Phe  Gln Asn Gly Glu Asp  Gly Asp Gly 
        995                 1000                 1005             


Asp Phe  Thr Ile Glu Pro Thr  Ser Gly Ile Val Arg  Thr Val Arg 
    1010                 1015                 1020             


Arg Leu  Asp Arg Glu Ala Val  Ser Val Tyr Glu Leu  Thr Ala Tyr 
    1025                 1030                 1035             


Ala Val  Asp Arg Gly Val Pro  Pro Leu Arg Thr Pro  Val Ser Ile 
    1040                 1045                 1050             


Gln Val  Met Val Gln Asp Val  Asn Asp Asn Ala Pro  Val Phe Pro 
    1055                 1060                 1065             


Ala Glu  Glu Phe Glu Val Arg  Val Lys Glu Asn Ser  Ile Val Gly 
    1070                 1075                 1080             


Ser Val  Val Ala Gln Ile Thr  Ala Val Asp Pro Asp  Glu Gly Pro 
    1085                 1090                 1095             


Asn Ala  His Ile Met Tyr Gln  Ile Val Glu Gly Asn  Ile Pro Glu 
    1100                 1105                 1110             


Leu Phe  Gln Met Asp Ile Phe  Ser Gly Glu Leu Thr  Ala Leu Ile 
    1115                 1120                 1125             


Asp Leu  Asp Tyr Glu Ala Arg  Gln Glu Tyr Val Ile  Val Val Gln 
    1130                 1135                 1140             


Ala Thr  Ser Ala Pro Leu Val  Ser Arg Ala Thr Val  His Val Arg 
    1145                 1150                 1155             


Leu Val  Asp Gln Asn Asp Asn  Ser Pro Val Leu Asn  Asn Phe Gln 
    1160                 1165                 1170             


Ile Leu  Phe Asn Asn Tyr Val  Ser Asn Arg Ser Asp  Thr Phe Pro 
    1175                 1180                 1185             


Ser Gly  Ile Ile Gly Arg Ile  Pro Ala Tyr Asp Pro  Asp Val Ser 
    1190                 1195                 1200             


Asp His  Leu Phe Tyr Ser Phe  Glu Arg Gly Asn Glu  Leu Gln Leu 
    1205                 1210                 1215             


Leu Val  Val Asn Gln Thr Ser  Gly Glu Leu Arg Leu  Ser Arg Lys 
    1220                 1225                 1230             


Leu Asp  Asn Asn Arg Pro Leu  Val Ala Ser Met Leu  Val Thr Val 
    1235                 1240                 1245             


Thr Asp  Gly Leu His Ser Val  Thr Ala Gln Cys Val  Leu Arg Val 
    1250                 1255                 1260             


Val Ile  Ile Thr Glu Glu Leu  Leu Ala Asn Ser Leu  Thr Val Arg 
    1265                 1270                 1275             


Leu Glu  Asn Met Trp Gln Glu  Arg Phe Leu Ser Pro  Leu Leu Gly 
    1280                 1285                 1290             


Arg Phe  Leu Glu Gly Val Ala  Ala Val Leu Ala Thr  Pro Ala Glu 
    1295                 1300                 1305             


Asp Val  Phe Ile Phe Asn Ile  Gln Asn Asp Thr Asp  Val Gly Gly 
    1310                 1315                 1320             


Thr Val  Leu Asn Val Ser Phe  Ser Ala Leu Ala Pro  Arg Gly Ala 
    1325                 1330                 1335             


Gly Ala  Gly Ala Ala Gly Pro  Trp Phe Ser Ser Glu  Glu Leu Gln 
    1340                 1345                 1350             


Glu Gln  Leu Tyr Val Arg Arg  Ala Ala Leu Ala Ala  Arg Ser Leu 
    1355                 1360                 1365             


Leu Asp  Val Leu Pro Phe Asp  Asp Asn Val Cys Leu  Arg Glu Pro 
    1370                 1375                 1380             


Cys Glu  Asn Tyr Met Lys Cys  Val Ser Val Leu Arg  Phe Asp Ser 
    1385                 1390                 1395             


Ser Ala  Pro Phe Leu Ala Ser  Ala Ser Thr Leu Phe  Arg Pro Ile 
    1400                 1405                 1410             


Gln Pro  Ile Ala Gly Leu Arg  Cys Arg Cys Pro Pro  Gly Phe Thr 
    1415                 1420                 1425             


Gly Asp  Phe Cys Glu Thr Glu  Leu Asp Leu Cys Tyr  Ser Asn Pro 
    1430                 1435                 1440             


Cys Arg  Asn Gly Gly Ala Cys  Ala Arg Arg Glu Gly  Gly Tyr Thr 
    1445                 1450                 1455             


Cys Val  Cys Arg Pro Arg Phe  Thr Gly Glu Asp Cys  Glu Leu Asp 
    1460                 1465                 1470             


Thr Glu  Ala Gly Arg Cys Val  Pro Gly Val Cys Arg  Asn Gly Gly 
    1475                 1480                 1485             


Thr Cys  Thr Asp Ala Pro Asn  Gly Gly Phe Arg Cys  Gln Cys Pro 
    1490                 1495                 1500             


Ala Gly  Gly Ala Phe Glu Gly  Pro Arg Cys Glu Val  Ala Ala Arg 
    1505                 1510                 1515             


Ser Phe  Pro Pro Ser Ser Phe  Val Met Phe Arg Gly  Leu Arg Gln 
    1520                 1525                 1530             


Arg Phe  His Leu Thr Leu Ser  Leu Ser Phe Ala Thr  Val Gln Gln 
    1535                 1540                 1545             


Ser Gly  Leu Leu Phe Tyr Asn  Gly Arg Leu Asn Glu  Lys His Asp 
    1550                 1555                 1560             


Phe Leu  Ala Leu Glu Leu Val  Ala Gly Gln Val Arg  Leu Thr Tyr 
    1565                 1570                 1575             


Ser Thr  Gly Glu Ser Asn Thr  Val Val Ser Pro Thr  Val Pro Gly 
    1580                 1585                 1590             


Gly Leu  Ser Asp Gly Gln Trp  His Thr Val His Leu  Arg Tyr Tyr 
    1595                 1600                 1605             


Asn Lys  Pro Arg Thr Asp Ala  Leu Gly Gly Ala Gln  Gly Pro Ser 
    1610                 1615                 1620             


Lys Asp  Lys Val Ala Val Leu  Ser Val Asp Asp Cys  Asp Val Ala 
    1625                 1630                 1635             


Val Ala  Leu Gln Phe Gly Ala  Glu Ile Gly Asn Tyr  Ser Cys Ala 
    1640                 1645                 1650             


Ala Ala  Gly Val Gln Thr Ser  Ser Lys Lys Ser Leu  Asp Leu Thr 
    1655                 1660                 1665             


Gly Pro  Leu Leu Leu Gly Gly  Val Pro Asn Leu Pro  Glu Asn Phe 
    1670                 1675                 1680             


Pro Val  Ser His Lys Asp Phe  Ile Gly Cys Met Arg  Asp Leu His 
    1685                 1690                 1695             


Ile Asp  Gly Arg Arg Val Asp  Met Ala Ala Phe Val  Ala Asn Asn 
    1700                 1705                 1710             


Gly Thr  Met Ala Gly Cys Gln  Ala Lys Leu His Phe  Cys Asp Ser 
    1715                 1720                 1725             


Gly Pro  Cys Lys Asn Ser Gly  Phe Cys Ser Glu Arg  Trp Gly Ser 
    1730                 1735                 1740             


Phe Ser  Cys Asp Cys Pro Val  Gly Phe Gly Gly Lys  Asp Cys Gln 
    1745                 1750                 1755             


Leu Thr  Met Ala His Pro His  His Phe Arg Gly Asn  Gly Thr Leu 
    1760                 1765                 1770             


Ser Trp  Asn Phe Gly Ser Asp  Met Ala Val Ser Val  Pro Trp Tyr 
    1775                 1780                 1785             


Leu Gly  Leu Ala Phe Arg Thr  Arg Ala Thr Gln Gly  Val Leu Met 
    1790                 1795                 1800             


Gln Val  Gln Ala Gly Pro His  Ser Thr Leu Leu Cys  Gln Leu Asp 
    1805                 1810                 1815             


Arg Gly  Leu Leu Ser Val Thr  Val Thr Arg Gly Ser  Gly Arg Ala 
    1820                 1825                 1830             


Ser His  Leu Leu Leu Asp Gln  Val Thr Val Ser Asp  Gly Arg Trp 
    1835                 1840                 1845             


His Asp  Leu Arg Leu Glu Leu  Gln Glu Glu Pro Gly  Gly Arg Arg 
    1850                 1855                 1860             


Gly His  His Val Leu Met Val  Ser Leu Asp Phe Ser  Leu Phe Gln 
    1865                 1870                 1875             


Asp Thr  Met Ala Val Gly Ser  Glu Leu Gln Gly Leu  Lys Val Lys 
    1880                 1885                 1890             


Gln Leu  His Val Gly Gly Leu  Pro Pro Gly Ser Ala  Glu Glu Ala 
    1895                 1900                 1905             


Pro Gln  Gly Leu Val Gly Cys  Ile Gln Gly Val Trp  Leu Gly Ser 
    1910                 1915                 1920             


Thr Pro  Ser Gly Ser Pro Ala  Leu Leu Pro Pro Ser  His Arg Val 
    1925                 1930                 1935             


Asn Ala  Glu Pro Gly Cys Val  Val Thr Asn Ala Cys  Ala Ser Gly 
    1940                 1945                 1950             


Pro Cys  Pro Pro His Ala Asp  Cys Arg Asp Leu Trp  Gln Thr Phe 
    1955                 1960                 1965             


Ser Cys  Thr Cys Gln Pro Gly  Tyr Tyr Gly Pro Gly  Cys Val Asp 
    1970                 1975                 1980             


Ala Cys  Leu Leu Asn Pro Cys  Gln Asn Gln Gly Ser  Cys Arg His 
    1985                 1990                 1995             


Leu Pro  Gly Ala Pro His Gly  Tyr Thr Cys Asp Cys  Val Gly Gly 
    2000                 2005                 2010             


Tyr Phe  Gly His His Cys Glu  His Arg Met Asp Gln  Gln Cys Pro 
    2015                 2020                 2025             


Arg Gly  Trp Trp Gly Ser Pro  Thr Cys Gly Pro Cys  Asn Cys Asp 
    2030                 2035                 2040             


Val His  Lys Gly Phe Asp Pro  Asn Cys Asn Lys Thr  Asn Gly Gln 
    2045                 2050                 2055             


Cys His  Cys Lys Glu Phe His  Tyr Arg Pro Arg Gly  Ser Asp Ser 
    2060                 2065                 2070             


Cys Leu  Pro Cys Asp Cys Tyr  Pro Val Gly Ser Thr  Ser Arg Ser 
    2075                 2080                 2085             


Cys Ala  Pro His Ser Gly Gln  Cys Pro Cys Arg Pro  Gly Ala Leu 
    2090                 2095                 2100             


Gly Arg  Gln Cys Asn Ser Cys  Asp Ser Pro Phe Ala  Glu Val Thr 
    2105                 2110                 2115             


Ala Ser  Gly Cys Arg Val Leu  Tyr Asp Ala Cys Pro  Lys Ser Leu 
    2120                 2125                 2130             


Arg Ser  Gly Val Trp Trp Pro  Gln Thr Lys Phe Gly  Val Leu Ala 
    2135                 2140                 2145             


Thr Val  Pro Cys Pro Arg Gly  Ala Leu Gly Ala Ala  Val Arg Leu 
    2150                 2155                 2160             


Cys Asp  Glu Ala Gln Gly Trp  Leu Glu Pro Asp Leu  Phe Asn Cys 
    2165                 2170                 2175             


Thr Ser  Pro Ala Phe Arg Glu  Leu Ser Leu Leu Leu  Asp Gly Leu 
    2180                 2185                 2190             


Glu Leu  Asn Lys Thr Ala Leu  Asp Thr Met Glu Ala  Lys Lys Leu 
    2195                 2200                 2205             


Ala Gln  Arg Leu Arg Glu Val  Thr Gly His Thr Asp  His Tyr Phe 
    2210                 2215                 2220             


Ser Gln  Asp Val Arg Val Thr  Ala Arg Leu Leu Ala  His Leu Leu 
    2225                 2230                 2235             


Ala Phe  Glu Ser His Gln Gln  Gly Phe Gly Leu Thr  Ala Thr Gln 
    2240                 2245                 2250             


Asp Ala  His Phe Asn Glu Asn  Leu Leu Trp Ala Gly  Ser Ala Leu 
    2255                 2260                 2265             


Leu Ala  Pro Glu Thr Gly Asp  Leu Trp Ala Ala Leu  Gly Gln Arg 
    2270                 2275                 2280             


Ala Pro  Gly Gly Ser Pro Gly  Ser Ala Gly Leu Val  Arg His Leu 
    2285                 2290                 2295             


Glu Glu  Tyr Ala Ala Thr Leu  Ala Arg Asn Met Glu  Leu Thr Tyr 
    2300                 2305                 2310             


Leu Asn  Pro Met Gly Leu Val  Thr Pro Asn Ile Met  Leu Ser Ile 
    2315                 2320                 2325             


Asp Arg  Met Glu His Pro Ser  Ser Pro Arg Gly Ala  Arg Arg Tyr 
    2330                 2335                 2340             


Pro Arg  Tyr His Ser Asn Leu  Phe Arg Gly Gln Asp  Ala Trp Asp 
    2345                 2350                 2355             


Pro His  Thr His Val Leu Leu  Pro Ser Gln Ser Pro  Arg Pro Ser 
    2360                 2365                 2370             


Pro Ser  Glu Val Leu Pro Thr  Ser Ser Ser Ile Glu  Asn Ser Thr 
    2375                 2380                 2385             


Thr Ser  Ser Val Val Pro Pro  Pro Ala Pro Pro Glu  Pro Glu Pro 
    2390                 2395                 2400             


Gly Ile  Ser Ile Ile Ile Leu  Leu Val Tyr Arg Thr  Leu Gly Gly 
    2405                 2410                 2415             


Leu Leu  Pro Ala Gln Phe Gln  Ala Glu Arg Arg Gly  Ala Arg Leu 
    2420                 2425                 2430             


Pro Gln  Asn Pro Val Met Asn  Ser Pro Val Val Ser  Val Ala Val 
    2435                 2440                 2445             


Phe His  Gly Arg Asn Phe Leu  Arg Gly Ile Leu Glu  Ser Pro Ile 
    2450                 2455                 2460             


Ser Leu  Glu Phe Arg Leu Leu  Gln Thr Ala Asn Arg  Ser Lys Ala 
    2465                 2470                 2475             


Ile Cys  Val Gln Trp Asp Pro  Pro Gly Leu Ala Glu  Gln His Gly 
    2480                 2485                 2490             


Val Trp  Thr Ala Arg Asp Cys  Glu Leu Val His Arg  Asn Gly Ser 
    2495                 2500                 2505             


His Ala  Arg Cys Arg Cys Ser  Arg Thr Gly Thr Phe  Gly Val Leu 
    2510                 2515                 2520             


Met Asp  Ala Ser Pro Arg Glu  Arg Leu Glu Gly Asp  Leu Glu Leu 
    2525                 2530                 2535             


Leu Ala  Val Phe Thr His Val  Val Val Ala Val Ser  Val Ala Ala 
    2540                 2545                 2550             


Leu Val  Leu Thr Ala Ala Ile  Leu Leu Ser Leu Arg  Ser Leu Lys 
    2555                 2560                 2565             


Ser Asn  Val Arg Gly Ile His  Ala Asn Val Ala Ala  Ala Leu Gly 
    2570                 2575                 2580             


Val Ala  Glu Leu Leu Phe Leu  Leu Gly Ile His Arg  Thr His Asn 
    2585                 2590                 2595             


Gln Leu  Val Cys Thr Ala Val  Ala Ile Leu Leu His  Tyr Phe Phe 
    2600                 2605                 2610             


Leu Ser  Thr Phe Ala Trp Leu  Phe Val Gln Gly Leu  His Leu Tyr 
    2615                 2620                 2625             


Arg Met  Gln Val Glu Pro Arg  Asn Val Asp Arg Gly  Ala Met Arg 
    2630                 2635                 2640             


Phe Tyr  His Ala Leu Gly Trp  Gly Val Pro Ala Val  Leu Leu Gly 
    2645                 2650                 2655             


Leu Ala  Val Gly Leu Asp Pro  Glu Gly Tyr Gly Asn  Pro Asp Phe 
    2660                 2665                 2670             


Cys Trp  Ile Ser Val His Glu  Pro Leu Ile Trp Ser  Phe Ala Gly 
    2675                 2680                 2685             


Pro Val  Val Leu Val Ile Val  Met Asn Gly Thr Met  Phe Leu Leu 
    2690                 2695                 2700             


Ala Ala  Arg Thr Ser Cys Ser  Thr Gly Gln Arg Glu  Ala Lys Lys 
    2705                 2710                 2715             


Thr Ser  Ala Leu Thr Leu Arg  Ser Ser Phe Leu Leu  Leu Leu Leu 
    2720                 2725                 2730             


Val Ser  Ala Ser Trp Leu Phe  Gly Leu Leu Ala Val  Asn His Ser 
    2735                 2740                 2745             


Ile Leu  Ala Phe His Tyr Leu  His Ala Gly Leu Cys  Gly Leu Gln 
    2750                 2755                 2760             


Gly Leu  Ala Val Leu Leu Leu  Phe Cys Val Leu Asn  Ala Asp Ala 
    2765                 2770                 2775             


Arg Ala  Ala Trp Met Pro Ala  Cys Leu Gly Arg Lys  Ala Ala Pro 
    2780                 2785                 2790             


Glu Glu  Ala Arg Pro Ala Pro  Gly Leu Gly Pro Gly  Ala Tyr Asn 
    2795                 2800                 2805             


Asn Thr  Ala Leu Phe Glu Glu  Ser Gly Leu Ile Arg  Ile Thr Leu 
    2810                 2815                 2820             


Gly Ala  Ser Thr Val Ser Ser  Val Ser Ser Ala Arg  Ser Gly Arg 
    2825                 2830                 2835             


Thr Gln  Asp Gln Asp Ser Gln  Arg Gly Arg Ser Tyr  Leu Arg Asp 
    2840                 2845                 2850             


Asn Val  Leu Val Arg His Gly  Ser Ala Ala Asp His  Thr Asp His 
    2855                 2860                 2865             


Ser Leu  Gln Ala His Ala Gly  Pro Thr Asp Leu Asp  Val Ala Met 
    2870                 2875                 2880             


Phe His  Arg Asp Ala Gly Ala  Asp Ser Asp Ser Asp  Ser Asp Leu 
    2885                 2890                 2895             


Ser Leu  Glu Glu Glu Arg Ser  Leu Ser Ile Pro Ser  Ser Glu Ser 
    2900                 2905                 2910             


Glu Asp  Asn Gly Arg Thr Arg  Gly Arg Phe Gln Arg  Pro Leu Cys 
    2915                 2920                 2925             


Arg Ala  Ala Gln Ser Glu Arg  Leu Leu Thr His Pro  Lys Asp Val 
    2930                 2935                 2940             


Asp Gly  Asn Asp Leu Leu Ser  Tyr Trp Pro Ala Leu  Gly Glu Cys 
    2945                 2950                 2955             


Glu Ala  Ala Pro Cys Ala Leu  Gln Thr Trp Gly Ser  Glu Arg Arg 
    2960                 2965                 2970             


Leu Gly  Leu Asp Thr Ser Lys  Asp Ala Ala Asn Asn  Asn Gln Pro 
    2975                 2980                 2985             


Asp Pro  Ala Leu Thr Ser Gly  Asp Glu Thr Ser Leu  Gly Arg Ala 
    2990                 2995                 3000             


Gln Arg  Gln Arg Lys Gly Ile  Leu Lys Asn Arg Leu  Gln Tyr Pro 
    3005                 3010                 3015             


Leu Val  Pro Gln Thr Arg Gly  Ala Pro Glu Leu Ser  Trp Cys Arg 
    3020                 3025                 3030             


Ala Ala  Thr Leu Gly His Arg  Ala Val Pro Ala Ala  Ser Tyr Gly 
    3035                 3040                 3045             


Arg Ile  Tyr Ala Gly Gly Gly  Thr Gly Ser Leu Ser  Gln Pro Ala 
    3050                 3055                 3060             


Ser Arg  Tyr Ser Ser Arg Glu  Gln Leu Asp Leu Leu  Leu Arg Arg 
    3065                 3070                 3075             


Gln Leu  Ser Arg Glu Arg Leu  Glu Glu Ala Pro Ala  Pro Val Leu 
    3080                 3085                 3090             


Arg Pro  Leu Ser Arg Pro Gly  Ser Gln Glu Cys Met  Asp Ala Ala 
    3095                 3100                 3105             


Pro Gly  Arg Leu Glu Pro Lys  Asp Arg Gly Ser Thr  Leu Pro Arg 
    3110                 3115                 3120             


Arg Gln  Pro Pro Arg Asp Tyr  Pro Gly Ala Met Ala  Gly Arg Phe 
    3125                 3130                 3135             


Gly Ser  Arg Asp Ala Leu Asp  Leu Gly Ala Pro Arg  Glu Trp Leu 
    3140                 3145                 3150             


Ser Thr  Leu Pro Pro Pro Arg  Arg Thr Arg Asp Leu  Asp Pro Gln 
    3155                 3160                 3165             


Pro Pro  Pro Leu Pro Leu Ser  Pro Gln Arg Gln Leu  Ser Arg Asp 
    3170                 3175                 3180             


Pro Leu  Leu Pro Ser Arg Pro  Leu Asp Ser Leu Ser  Arg Ser Ser 
    3185                 3190                 3195             


Asn Ser  Arg Glu Gln Leu Asp  Gln Val Pro Ser Arg  His Pro Ser 
    3200                 3205                 3210             


Arg Glu  Ala Leu Gly Pro Leu  Pro Gln Leu Leu Arg  Ala Arg Glu 
    3215                 3220                 3225             


Asp Ser  Val Ser Gly Pro Ser  His Gly Pro Ser Thr  Glu Gln Leu 
    3230                 3235                 3240             


Asp Ile  Leu Ser Ser Ile Leu  Ala Ser Phe Asn Ser  Ser Ala Leu 
    3245                 3250                 3255             


Ser Ser  Val Gln Ser Ser Ser  Thr Pro Leu Gly Pro  His Thr Thr 
    3260                 3265                 3270             


Ala Thr  Pro Ser Ala Thr Ala  Ser Val Leu Gly Pro  Ser Thr Pro 
    3275                 3280                 3285             


Arg Ser  Ala Thr Ser His Ser  Ile Ser Glu Leu Ser  Pro Asp Ser 
    3290                 3295                 3300             


Glu Val  Pro Arg Ser Glu Gly  His Ser 
    3305                 3310         


<210>  5710
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  5710

Met Val Ala Trp Arg Ser Ala Phe Leu Val Cys Leu Ala Phe Ser Leu 
1               5                   10                  15      


Ala Thr Leu Val Gln Arg Gly Ser Gly Asp Phe Asp Asp Phe Asn Leu 
            20                  25                  30          


Glu Asp Ala Val Lys Glu Thr Ser Ser Val Lys Arg Asn Asp Phe Asp 
        35                  40                  45              


Leu Ala Asp Ala Leu Asp Asp Arg Asn Asp Arg Asp Asp Gly Arg Arg 
    50                  55                  60                  


Lys Pro Ile Ala Gly Gly Gly Gly Phe Ser Asp Lys Asp Leu Glu Asp 
65                  70                  75                  80  


Ile Val Gly Gly Gly Glu Tyr Lys Pro Asp Lys Gly Lys Gly Asp Gly 
                85                  90                  95      


Arg Tyr Gly Ser Asn Asp Asp Pro Gly Ser Gly Met Val Ala Glu Pro 
            100                 105                 110         


Gly Thr Ile Ala Gly Val Ala Ser Ala Leu Ala Met Ala Leu Ile Gly 
        115                 120                 125             


Ala Val Ser Ser Tyr Ile Ser Tyr Gln Gln Lys Lys Phe Cys Phe Ser 
    130                 135                 140                 


Ile Gln Gln Gly Leu Asn Ala Asp Tyr Val Lys Gly Glu Asn Leu Glu 
145                 150                 155                 160 


Ala Val Val Cys Glu Glu Pro Gln Val Lys Tyr Ser Thr Leu His Thr 
                165                 170                 175     


Gln Ser Ala Glu Pro Pro Pro Pro Pro Glu Pro Ala Arg Ile 
            180                 185                 190 


<210>  5711
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  5711

Met Val Ala Trp Arg Ser Ala Phe Leu Val Cys Leu Ala Phe Ser Leu 
1               5                   10                  15      


Ala Thr Leu Val Gln Arg Gly Ser Gly Asp Phe Asp Asp Phe Asn Leu 
            20                  25                  30          


Glu Asp Ala Val Lys Glu Thr Ser Ser Val Lys Gln Arg Trp Asn His 
        35                  40                  45              


Val Thr Thr Thr Thr Lys Arg Pro Val Thr Thr Arg Ala Pro Ala Asn 
    50                  55                  60                  


Thr Leu Gly Asn Asp Phe Asp Leu Ala Asp Ala Leu Asp Asp Arg Asn 
65                  70                  75                  80  


Asp Arg Asp Asp Gly Arg Arg Lys Pro Ile Ala Gly Gly Gly Gly Phe 
                85                  90                  95      


Ser Asp Lys Asp Leu Glu Asp Ile Val Gly Gly Gly Glu Tyr Lys Pro 
            100                 105                 110         


Asp Lys Gly Lys Gly Asp Gly Arg Tyr Gly Ser Asn Asp Asp Pro Gly 
        115                 120                 125             


Ser Gly Met Val Ala Glu Pro Gly Thr Ile Ala Gly Val Ala Ser Ala 
    130                 135                 140                 


Leu Ala Met Ala Leu Ile Gly Ala Val Ser Ser Tyr Ile Ser Tyr Gln 
145                 150                 155                 160 


Gln Lys Lys Phe Cys Phe Ser Ile Gln Gln Gly Leu Asn Ala Asp Tyr 
                165                 170                 175     


Val Lys Gly Glu Asn Leu Glu Ala Val Val Cys Glu Glu Pro Gln Val 
            180                 185                 190         


Lys Tyr Ser Thr Leu His Thr Gln Ser Ala Glu Pro Pro Pro Pro Pro 
        195                 200                 205             


Glu Pro Ala Arg Ile 
    210             


<210>  5712
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  5712

Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu 
1               5                   10                  15      


Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met 
            20                  25                  30          


Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro 
        35                  40                  45              


Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala 
    50                  55                  60                  


Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu 
65                  70                  75                  80  


Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys 
                85                  90                  95      


Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro 
        115                 120                 125             


Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu 
    130                 135                 140                 


Pro Val His Lys Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys 
145                 150                 155                 160 


Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr 
                165                 170                 175     


Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro 
            180                 185                 190         


Glu Gly Met Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly 
        195                 200                 205             


Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His 
    210                 215                 220                 


Leu Thr Arg Thr Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala 
225                 230                 235                 240 


Val Pro Pro Val Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys 
                245                 250                 255     


Glu Pro Gly Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe 
            260                 265                 270         


Leu Met Asp Ser Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys 
        275                 280                 285             


Pro Asp Asp Ile Thr Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His 
    290                 295                 300                 


Ser Arg Thr Glu Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys 
305                 310                 315                 320 


Val Thr Ser Glu Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser 
                325                 330                 335     


Ala Lys Gly Glu Val Ala Lys Ala Ala Lys Val Lys Gln Lys Gly Asn 
            340                 345                 350         


Arg Cys Gly Gln 
        355     


<210>  5713
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  5713

Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Thr Pro Thr Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Thr Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Thr Val Leu His Val Leu Gly Asp Arg Thr Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Thr His Gly Ser Val Tyr Pro Gln Leu Leu 
    130                 135                 140                 


Ile Pro Leu Leu Gly Ala Gly Leu Val Leu Gly Leu Gly Ala Leu Gly 
145                 150                 155                 160 


Leu Val Trp Trp Leu His Arg Arg Leu Pro Pro Gln Pro Ile Arg Pro 
                165                 170                 175     


Leu Pro Arg Phe Ala Pro Leu Val Lys Thr Glu Pro Gln Arg Pro Val 
            180                 185                 190         


Lys Glu Glu Glu Pro Lys Ile Pro Gly Asp Leu Asp Gln Glu Pro Ser 
        195                 200                 205             


Leu Leu Tyr Ala Asp Leu Asp His Leu Ala Leu Ser Arg Pro Arg Arg 
    210                 215                 220                 


Leu Ser Thr Ala Asp Pro Ala Asp Ala Ser Thr Ile Tyr Ala Val Val 
225                 230                 235                 240 


Val 
    


<210>  5714
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  5714

Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Thr Pro Thr Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Thr Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Thr Val Leu His Val Leu Gly Asp Arg Thr Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Thr His Gly Ala Cys Pro Arg Asn Arg Phe 
    130                 135                 140                 


Asp His Ser Leu Asp Leu Leu Cys Pro Pro His Ile Ala Pro Leu Val 
145                 150                 155                 160 


Lys Thr Glu Pro Gln Arg Pro Val Lys Glu Glu Glu Pro Lys Ile Pro 
                165                 170                 175     


Gly Asp Leu Asp Gln Glu Pro Ser Leu Leu Tyr Ala Asp Leu Asp His 
            180                 185                 190         


Leu Ala Leu Ser Arg Pro Arg Arg Leu Ser Thr Ala Asp Pro Ala Asp 
        195                 200                 205             


Ala Ser Thr Ile Tyr Ala Val Val Val 
    210                 215         


<210>  5715
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  5715

Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Thr Pro Thr Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Thr Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Thr Val Leu His Val Leu Gly Asp Arg Thr Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Thr His Ala Leu Ser Pro Pro His Ser Ser 
    130                 135                 140                 


Thr Cys Glu Asn Arg Ala Pro Glu Ala Ser Lys Gly Gly Arg Ala Gln 
145                 150                 155                 160 


Asp Ser Arg Gly Pro Gly Pro Gly Thr Glu Pro Ala Leu Cys Gly Ser 
                165                 170                 175     


Gly Pro Ser Ser Pro Gln Gln Ala Pro Pro Ala Val His Ser Gly Pro 
            180                 185                 190         


Cys 
    


<210>  5716
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  5716

Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Thr Pro Thr Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Thr Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Thr Val Leu His Val Leu Gly Asp Arg Thr Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Thr His Ala Pro Leu Val Lys Thr Glu Pro 
    130                 135                 140                 


Gln Arg Pro Val Lys Glu Glu Glu Pro Lys Ile Pro Gly Asp Leu Asp 
145                 150                 155                 160 


Gln Glu Pro Ser Leu Leu Tyr Ala Asp Leu Asp His Leu Ala Leu Ser 
                165                 170                 175     


Arg Pro Arg Arg Leu Ser Thr Ala Asp Pro Ala Asp Ala Ser Thr Ile 
            180                 185                 190         


Tyr Ala Val Val Val 
        195         


<210>  5717
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  5717

Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Thr Pro Thr Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Thr Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Thr Val Leu His Val Leu Gly Asp Arg Thr Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Thr His Gly Ser Val Tyr Pro Gln Leu Leu 
    130                 135                 140                 


Ile Pro Leu Leu Gly Ala Gly Leu Val Leu Gly Leu Gly Ala Leu Gly 
145                 150                 155                 160 


Leu Val Trp Trp Leu His Arg Arg Leu Pro Pro Gln Pro Ile Arg Pro 
                165                 170                 175     


Leu Pro Arg Phe Ala Leu Ser Pro Pro His Ser Ser Thr Cys Glu Asn 
            180                 185                 190         


Arg Ala Pro Glu Ala Ser Lys Gly Gly Arg Ala Gln Asp Ser Arg Gly 
        195                 200                 205             


Pro Gly Pro Gly Thr Gly Lys Gly Met Gly Met Gly Arg Gly 
    210                 215                 220         


<210>  5718
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  5718

Met Leu Val Ala Gly Phe Leu Leu Ala Leu Pro Pro Ser Trp Ala Ala 
1               5                   10                  15      


Gly Ala Pro Arg Ala Gly Arg Arg Pro Ala Arg Pro Arg Gly Cys Ala 
            20                  25                  30          


Asp Arg Pro Glu Glu Leu Leu Glu Gln Leu Tyr Gly Arg Leu Ala Ala 
        35                  40                  45              


Gly Val Leu Ser Ala Phe His His Thr Leu Gln Leu Gly Pro Arg Glu 
    50                  55                  60                  


Gln Ala Arg Asn Ala Ser Cys Pro Ala Gly Gly Arg Pro Ala Asp Arg 
65                  70                  75                  80  


Arg Phe Arg Pro Pro Thr Asn Leu Arg Ser Val Ser Pro Trp Ala Tyr 
                85                  90                  95      


Arg Ile Ser Tyr Asp Pro Ala Arg Tyr Pro Arg Tyr Leu Pro Glu Ala 
            100                 105                 110         


Tyr Cys Leu Cys Arg Gly Cys Leu Thr Gly Leu Phe Gly Glu Glu Asp 
        115                 120                 125             


Val Arg Phe Arg Ser Ala Pro Val Tyr Met Pro Thr Val Val Leu Arg 
    130                 135                 140                 


Arg Thr Pro Ala Cys Ala Gly Gly Arg Ser Val Tyr Thr Glu Ala Tyr 
145                 150                 155                 160 


Val Thr Ile Pro Val Gly Cys Thr Cys Val Pro Glu Pro Glu Lys Asp 
                165                 170                 175     


Ala Asp Ser Ile Asn Ser Ser Ile Asp Lys Gln Gly Ala Lys Leu Leu 
            180                 185                 190         


Leu Gly Pro Asn Asp Ala Pro Ala Gly Pro 
        195                 200         


<210>  5719
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  5719

Met Ala Gly Met Ala Leu Ala Arg Ala Trp Lys Gln Met Ser Trp Phe 
1               5                   10                  15      


Tyr Tyr Gln Tyr Leu Leu Val Thr Ala Leu Tyr Met Leu Glu Pro Trp 
            20                  25                  30          


Glu Arg Thr Val Phe Asn Ser Met Leu Val Ser Ile Val Gly Met Ala 
        35                  40                  45              


Leu Tyr Thr Gly Tyr Val Phe Met Pro Gln His Ile Met Ala Ile Leu 
    50                  55                  60                  


His Tyr Phe Glu Ile Val Gln 
65                  70      


<210>  5720
<211>  2849
<212>  PRT
<213>  Homo sapiens

<400>  5720

Met Ala Glu Glu Ala Ala Gln Asn Ile Ser Asp Asp Gln Glu Arg Cys 
1               5                   10                  15      


Leu Gln Ala Ala Cys Cys Leu Ser Phe Gly Gly Glu Leu Ser Val Ser 
            20                  25                  30          


Thr Asp Lys Ser Trp Gly Leu His Leu Cys Ser Cys Ser Pro Pro Gly 
        35                  40                  45              


Gly Gly Leu Trp Val Glu Val Tyr Ala Asn His Val Leu Leu Met Ser 
    50                  55                  60                  


Asp Gly Lys Cys Gly Cys Pro Trp Cys Ala Leu Asn Gly Lys Ala Glu 
65                  70                  75                  80  


Asp Arg Glu Ser Gln Ser Pro Ser Ser Ser Ala Ser Arg Gln Lys Asn 
                85                  90                  95      


Ile Trp Lys Thr Thr Ser Glu Ala Ala Leu Ser Val Val Asn Glu Lys 
            100                 105                 110         


Thr Gln Ala Val Val Asn Glu Lys Thr Gln Ala Pro Leu Asp Cys Asp 
        115                 120                 125             


Asn Ser Ala Asp Arg Ile Pro His Lys Pro Phe Ile Ile Ile Ala Arg 
    130                 135                 140                 


Ala Trp Ser Ser Gly Gly Pro Arg Phe His His Arg Arg Leu Cys Ala 
145                 150                 155                 160 


Thr Gly Thr Ala Asp Ser Thr Phe Ser Ala Leu Leu Gln Leu Gln Gly 
                165                 170                 175     


Thr Thr Ser Ala Ala Ala Pro Cys Ser Leu Lys Met Glu Ala Ser Cys 
            180                 185                 190         


Cys Val Leu Arg Leu Leu Cys Cys Ala Glu Asp Val Ala Thr Gly Leu 
        195                 200                 205             


Leu Pro Gly Thr Val Thr Met Glu Thr Pro Thr Lys Val Ala Arg Pro 
    210                 215                 220                 


Thr Gln Thr Ser Ser Gln Arg Val Pro Leu Trp Pro Ile Ser His Phe 
225                 230                 235                 240 


Pro Thr Ser Pro Arg Ser Ser His Gly Leu Pro Pro Gly Ile Pro Arg 
                245                 250                 255     


Thr Pro Ser Phe Thr Ala Ser Gln Ser Gly Ser Glu Ile Leu Tyr Pro 
            260                 265                 270         


Pro Thr Gln His Pro Pro Val Ala Ile Leu Ala Arg Asn Ser Asp Asn 
        275                 280                 285             


Phe Met Asn Pro Val Leu Asn Cys Ser Leu Glu Val Glu Ala Arg Ala 
    290                 295                 300                 


Pro Pro Asn Leu Gly Phe Arg Val His Met Ala Ser Gly Glu Ala Leu 
305                 310                 315                 320 


Cys Leu Met Met Asp Phe Gly Asp Ser Ser Gly Val Glu Met Arg Leu 
                325                 330                 335     


His Asn Met Ser Glu Ala Met Ala Val Thr Ala Tyr His Gln Tyr Ser 
            340                 345                 350         


Lys Gly Ile Phe Phe His Leu Leu His Phe Gln Leu Asp Met Ser Thr 
        355                 360                 365             


Tyr Lys Glu Ala Glu Thr Gln Asn Thr Thr Leu Asn Val Tyr Leu Cys 
    370                 375                 380                 


Gln Ser Glu Asn Ser Cys Leu Glu Asp Ser Asp Pro Ser Asn Leu Gly 
385                 390                 395                 400 


Tyr Glu Leu Ile Ser Ala Phe Val Thr Lys Gly Val Tyr Met Leu Lys 
                405                 410                 415     


Ala Val Ile Tyr Asn Glu Phe His Gly Thr Glu Val Glu Leu Gly Pro 
            420                 425                 430         


Tyr Tyr Val Glu Ile Gly His Glu Ala Val Ser Ala Phe Met Asn Ser 
        435                 440                 445             


Ser Ser Val His Glu Asp Glu Val Leu Val Phe Ala Asp Ser Gln Val 
    450                 455                 460                 


Asn Gln Lys Ser Thr Val Val Ile His His Phe Pro Ser Ile Pro Ser 
465                 470                 475                 480 


Tyr Asn Val Ser Phe Ile Ser Gln Thr Gln Val Gly Asp Ser Gln Ala 
                485                 490                 495     


Trp His Ser Met Thr Val Trp Tyr Lys Met Gln Ser Val Ser Val Tyr 
            500                 505                 510         


Thr Asn Gly Thr Val Phe Ala Thr Asp Thr Asp Ile Thr Phe Thr Ala 
        515                 520                 525             


Val Thr Lys Glu Thr Ile Pro Leu Glu Phe Glu Trp Tyr Phe Gly Glu 
    530                 535                 540                 


Asp Pro Pro Val Arg Thr Thr Ser Arg Ser Ile Lys Lys Arg Leu Ser 
545                 550                 555                 560 


Ile Pro Gln Trp Tyr Arg Val Met Val Lys Ala Ser Asn Arg Met Ser 
                565                 570                 575     


Ser Val Val Ser Glu Pro His Val Ile Arg Val Gln Lys Lys Ile Val 
            580                 585                 590         


Ala Asn Arg Leu Thr Ser Pro Ser Ser Ala Leu Val Asn Ala Ser Val 
        595                 600                 605             


Ala Phe Glu Cys Trp Ile Asn Phe Gly Thr Asp Val Ala Tyr Leu Trp 
    610                 615                 620                 


Asp Phe Gly Asp Gly Thr Val Ser Leu Gly Ser Ser Ser Ser Ser His 
625                 630                 635                 640 


Val Tyr Ser Arg Glu Gly Glu Phe Thr Val Glu Val Leu Ala Phe Asn 
                645                 650                 655     


Asn Val Ser Ala Ser Thr Leu Arg Gln Gln Leu Phe Ile Val Cys Glu 
            660                 665                 670         


Pro Cys Gln Pro Pro Leu Val Lys Asn Met Gly Pro Gly Lys Val Gln 
        675                 680                 685             


Ile Trp Arg Ser Gln Pro Val Arg Leu Gly Val Thr Phe Glu Ala Ala 
    690                 695                 700                 


Val Phe Cys Asp Ile Ser Gln Gly Leu Ser Tyr Thr Trp Asn Leu Met 
705                 710                 715                 720 


Asp Ser Glu Gly Leu Pro Val Ser Leu Pro Ala Ala Val Asp Thr His 
                725                 730                 735     


Arg Gln Thr Leu Ile Leu Pro Ser His Thr Leu Glu Tyr Gly Asn Tyr 
            740                 745                 750         


Thr Ala Leu Ala Lys Val Gln Ile Glu Gly Ser Val Val Tyr Ser Asn 
        755                 760                 765             


Tyr Cys Val Gly Leu Glu Val Arg Ala Gln Ala Pro Val Ser Val Ile 
    770                 775                 780                 


Ser Glu Gly Thr His Leu Phe Phe Ser Arg Thr Thr Ser Ser Pro Ile 
785                 790                 795                 800 


Val Leu Arg Gly Thr Gln Ser Phe Asp Pro Asp Asp Pro Gly Ala Thr 
                805                 810                 815     


Leu Arg Tyr His Trp Glu Cys Ala Thr Ala Gly Ser Pro Ala His Pro 
            820                 825                 830         


Cys Phe Asp Ser Ser Thr Ala His Gln Leu Asp Ala Ala Ala Pro Thr 
        835                 840                 845             


Val Ser Phe Glu Ala Gln Trp Leu Ser Asp Ser Tyr Asp Gln Phe Leu 
    850                 855                 860                 


Val Met Leu Arg Val Ser Ser Gly Gly Arg Asn Ser Ser Glu Thr Arg 
865                 870                 875                 880 


Val Phe Leu Ser Pro Tyr Pro Asp Ser Ala Phe Arg Phe Val His Ile 
                885                 890                 895     


Ser Trp Val Ser Phe Lys Asp Thr Phe Val Asn Trp Asn Asp Glu Leu 
            900                 905                 910         


Ser Leu Gln Ala Met Cys Glu Asp Cys Ser Glu Ile Pro Asn Leu Ser 
        915                 920                 925             


Tyr Ser Trp Asp Leu Phe Leu Val Asn Ala Thr Glu Lys Asn Arg Ile 
    930                 935                 940                 


Glu Val Pro Phe Cys Arg Val Val Gly Leu Leu Gly Ser Leu Gly Leu 
945                 950                 955                 960 


Gly Ala Ile Ser Glu Ser Ser Gln Leu Asn Leu Leu Pro Thr Glu Pro 
                965                 970                 975     


Gly Thr Ala Asp Pro Asp Ala Thr Thr Thr Pro Phe Ser Arg Glu Pro 
            980                 985                 990         


Ser Pro Val Thr Leu Gly Gln Pro  Ala Thr Ser Ala Pro  Arg Gly Thr 
        995                 1000                 1005             


Pro Thr  Glu Pro Met Thr Gly  Val Tyr Trp Ile Pro  Pro Ala Gly 
    1010                 1015                 1020             


Asp Ser  Ala Val Leu Gly Glu  Ala Pro Glu Glu Gly  Ser Leu Asp 
    1025                 1030                 1035             


Leu Glu  Pro Gly Pro Gln Ser  Lys Gly Ser Leu Met  Thr Gly Arg 
    1040                 1045                 1050             


Ser Glu  Arg Ser Gln Pro Thr  His Ser Pro Asp Pro  His Leu Ser 
    1055                 1060                 1065             


Asp Phe  Glu Ala Tyr Tyr Ser  Asp Ile Gln Glu Ala  Ile Pro Ser 
    1070                 1075                 1080             


Gly Gly  Arg Gln Pro Ala Lys  Asp Thr Ser Phe Pro  Gly Ser Gly 
    1085                 1090                 1095             


Pro Ser  Leu Ser Ala Glu Glu  Ser Pro Gly Asp Gly  Asp Asn Leu 
    1100                 1105                 1110             


Val Asp  Pro Ser Leu Ser Ala  Gly Arg Ala Glu Pro  Val Leu Met 
    1115                 1120                 1125             


Ile Asp  Trp Pro Lys Ala Leu  Leu Gly Arg Ala Val  Phe Gln Gly 
    1130                 1135                 1140             


Tyr Ser  Ser Ser Gly Ile Thr  Glu Gln Thr Val Thr  Ile Lys Pro 
    1145                 1150                 1155             


Tyr Ser  Leu Ser Ser Gly Glu  Thr Tyr Val Leu Gln  Val Ser Val 
    1160                 1165                 1170             


Ala Ser  Lys His Gly Leu Leu  Gly Lys Ala Gln Leu  Tyr Leu Thr 
    1175                 1180                 1185             


Val Asn  Pro Ala Pro Arg Asp  Met Ala Cys Gln Val  Gln Pro His 
    1190                 1195                 1200             


His Gly  Leu Glu Ala His Thr  Val Phe Ser Val Phe  Cys Met Ser 
    1205                 1210                 1215             


Gly Lys  Pro Asp Phe His Tyr  Glu Phe Ser Tyr Gln  Ile Gly Asn 
    1220                 1225                 1230             


Thr Ser  Lys His Thr Leu Tyr  His Gly Arg Asp Thr  Gln Tyr Tyr 
    1235                 1240                 1245             


Phe Val  Leu Pro Ala Gly Glu  His Leu Asp Asn Tyr  Lys Val Met 
    1250                 1255                 1260             


Val Ser  Thr Glu Ile Thr Asp  Gly Lys Gly Ser Lys  Val Gln Pro 
    1265                 1270                 1275             


Cys Thr  Val Val Val Thr Val  Leu Pro Arg Tyr His  Gly Asn Asp 
    1280                 1285                 1290             


Cys Leu  Gly Glu Asp Leu Tyr  Asn Ser Ser Leu Lys  Asn Leu Ser 
    1295                 1300                 1305             


Thr Leu  Gln Leu Met Gly Ser  Tyr Thr Glu Ile Arg  Asn Tyr Ile 
    1310                 1315                 1320             


Thr Val  Ile Thr Arg Ile Leu  Ser Arg Leu Ser Lys  Glu Asp Lys 
    1325                 1330                 1335             


Thr Ala  Ser Cys Asn Gln Trp  Ser Arg Ile Gln Asp  Ala Leu Ile 
    1340                 1345                 1350             


Ser Ser  Val Cys Arg Leu Ala  Phe Val Asp Gln Glu  Glu Met Ile 
    1355                 1360                 1365             


Gly Ser  Val Leu Met Leu Arg  Asp Leu Val Ser Phe  Ser Asn Lys 
    1370                 1375                 1380             


Leu Gly  Phe Met Ser Ala Val  Leu Ile Leu Lys Tyr  Thr Arg Ala 
    1385                 1390                 1395             


Leu Leu  Ala Gln Gly Gln Phe  Ser Gly Pro Phe Val  Ile Asp Lys 
    1400                 1405                 1410             


Gly Val  Arg Leu Glu Leu Ile  Gly Leu Ile Ser Arg  Val Trp Glu 
    1415                 1420                 1425             


Val Ser  Glu Gln Glu Asn Ser  Lys Glu Glu Val Tyr  Arg His Glu 
    1430                 1435                 1440             


Glu Gly  Ile Thr Val Ile Ser  Asp Leu Leu Leu Gly  Cys Leu Ser 
    1445                 1450                 1455             


Leu Asn  His Val Ser Thr Gly  Gln Met Glu Phe Arg  Thr Leu Leu 
    1460                 1465                 1470             


His Tyr  Asn Leu Gln Ser Ser  Val Gln Ser Leu Gly  Ser Val Gln 
    1475                 1480                 1485             


Val His  Leu Pro Gly Asp Leu  Ala Gly His Ser Pro  Ala Gly Ala 
    1490                 1495                 1500             


Glu Thr  Gln Ser Pro Cys Tyr  Ile Ser Gln Leu Ile  Leu Phe Lys 
    1505                 1510                 1515             


Lys Asn  Pro Tyr Pro Gly Ser  Gln Ala Pro Gly Gln  Ile Gly Gly 
    1520                 1525                 1530             


Val Val  Gly Leu Asn Leu Tyr  Thr Cys Ser Ser Arg  Arg Pro Ile 
    1535                 1540                 1545             


Asn Arg  Gln Trp Leu Arg Lys  Pro Val Met Val Glu  Phe Gly Glu 
    1550                 1555                 1560             


Glu Asp  Gly Leu Asp Asn Arg  Arg Asn Lys Thr Thr  Phe Val Leu 
    1565                 1570                 1575             


Leu Arg  Asp Lys Val Asn Leu  His Gln Phe Thr Glu  Leu Ser Glu 
    1580                 1585                 1590             


Asn Pro  Gln Glu Ser Leu Gln  Ile Glu Ile Glu Phe  Ser Lys Pro 
    1595                 1600                 1605             


Val Thr  Arg Ala Phe Pro Val  Met Leu Leu Val Arg  Phe Ser Glu 
    1610                 1615                 1620             


Lys Pro  Thr Pro Ser Asp Phe  Leu Val Lys Gln Ile  Tyr Phe Trp 
    1625                 1630                 1635             


Asp Glu  Ser Ile Val Gln Ile  Tyr Ile Pro Ala Ala  Ser Gln Lys 
    1640                 1645                 1650             


Asp Ala  Ser Val Gly Tyr Leu  Ser Leu Leu Asp Ala  Asp Tyr Asp 
    1655                 1660                 1665             


Arg Lys  Pro Pro Asn Arg Tyr  Leu Ala Lys Ala Val  Asn Tyr Thr 
    1670                 1675                 1680             


Val His  Phe Gln Trp Ile Arg  Cys Leu Phe Trp Asp  Lys Arg Glu 
    1685                 1690                 1695             


Trp Lys  Ser Glu Arg Phe Ser  Pro Gln Pro Gly Thr  Ser Pro Glu 
    1700                 1705                 1710             


Lys Val  Asn Cys Ser Tyr His  Arg Leu Ala Ala Phe  Ala Leu Leu 
    1715                 1720                 1725             


Arg Arg  Lys Leu Lys Ala Ser  Phe Glu Val Ser Asp  Ile Ser Lys 
    1730                 1735                 1740             


Leu Gln  Ser His Pro Glu Asn  Leu Leu Pro Ser Ile  Phe Ile Met 
    1745                 1750                 1755             


Gly Ser  Val Ile Leu Tyr Gly  Phe Leu Val Ala Lys  Ser Arg Gln 
    1760                 1765                 1770             


Val Asp  His His Glu Lys Lys  Lys Ala Gly Tyr Ile  Phe Leu Gln 
    1775                 1780                 1785             


Glu Ala  Ser Leu Pro Gly His  Gln Leu Tyr Ala Val  Val Ile Asp 
    1790                 1795                 1800             


Thr Gly  Phe Arg Ala Pro Ala  Arg Leu Thr Ser Lys  Val Tyr Ile 
    1805                 1810                 1815             


Val Leu  Cys Gly Asp Asn Gly  Leu Ser Glu Thr Lys  Glu Leu Ser 
    1820                 1825                 1830             


Cys Pro  Glu Lys Pro Leu Phe  Glu Arg Asn Ser Arg  His Thr Phe 
    1835                 1840                 1845             


Ile Leu  Ser Ala Pro Ala Gln  Leu Gly Leu Leu Arg  Lys Ile Arg 
    1850                 1855                 1860             


Leu Trp  His Asp Ser Arg Gly  Pro Ser Pro Gly Trp  Phe Ile Ser 
    1865                 1870                 1875             


His Val  Met Val Lys Glu Leu  His Thr Gly Gln Gly  Trp Phe Phe 
    1880                 1885                 1890             


Pro Ala  Gln Cys Trp Leu Ser  Ala Gly Arg His Asp  Gly Arg Val 
    1895                 1900                 1905             


Glu Arg  Glu Leu Thr Cys Leu  Gln Gly Gly Leu Gly  Phe Arg Lys 
    1910                 1915                 1920             


Leu Phe  Tyr Cys Lys Phe Thr  Glu Tyr Leu Glu Asp  Phe His Val 
    1925                 1930                 1935             


Trp Leu  Ser Val Tyr Ser Arg  Pro Ser Ser Ser Arg  Tyr Leu His 
    1940                 1945                 1950             


Thr Pro  Arg Leu Thr Val Ser  Phe Ser Leu Leu Cys  Val Tyr Ala 
    1955                 1960                 1965             


Cys Leu  Thr Ala Leu Val Ala  Ala Gly Gly Gln Glu  Gln Pro His 
    1970                 1975                 1980             


Leu Asp  Val Ser Pro Thr Leu  Gly Ser Phe Arg Val  Gly Leu Leu 
    1985                 1990                 1995             


Cys Thr  Leu Leu Ala Ser Pro  Gly Ala Gln Leu Leu  Ser Leu Leu 
    2000                 2005                 2010             


Phe Arg  Leu Ser Lys Glu Ala  Pro Gly Ser Ala Arg  Val Glu Pro 
    2015                 2020                 2025             


His Ser  Pro Leu Arg Gly Gly  Ala Gln Thr Glu Ala  Pro His Gly 
    2030                 2035                 2040             


Pro Asn  Ser Trp Gly Arg Ile  Pro Asp Ala Gln Glu  Pro Arg Lys 
    2045                 2050                 2055             


Gln Pro  Ala Ser Ala Ile Leu  Ser Gly Ser Gly Arg  Ala Gln Arg 
    2060                 2065                 2070             


Lys Ala  Ala Ser Asp Asn Gly  Thr Ala Cys Pro Ala  Pro Lys Leu 
    2075                 2080                 2085             


Gln Val  His Gly Ala Asp His  Ser Arg Thr Ser Leu  Met Gly Lys 
    2090                 2095                 2100             


Ser His  Cys Cys Pro Pro His  Thr Gln Ala Pro Ser  Ser Gly Leu 
    2105                 2110                 2115             


Glu Gly  Leu Met Pro Gln Trp  Ser Arg Ala Leu Gln  Pro Trp Trp 
    2120                 2125                 2130             


Ser Ser  Ala Val Trp Ala Ile  Cys Gly Thr Ala Ser  Leu Ala Cys 
    2135                 2140                 2145             


Ser Leu  Gly Thr Gly Phe Leu  Ala Tyr Arg Phe Gly  Gln Glu Gln 
    2150                 2155                 2160             


Cys Val  Gln Trp Leu His Leu  Leu Ser Leu Ser Val  Val Cys Cys 
    2165                 2170                 2175             


Ile Phe  Ile Thr Gln Pro Leu  Met Val Cys Leu Met  Ala Leu Gly 
    2180                 2185                 2190             


Phe Ala  Trp Lys Arg Arg Ala  Asp Asn His Phe Phe  Thr Glu Ser 
    2195                 2200                 2205             


Leu Cys  Glu Ala Thr Arg Asp  Leu Asp Ser Glu Leu  Ala Glu Arg 
    2210                 2215                 2220             


Ser Trp  Thr Arg Leu Pro Phe  Ser Ser Ser Cys Ser  Ile Pro Asp 
    2225                 2230                 2235             


Cys Ala  Gly Glu Val Glu Lys  Val Leu Ala Ala Arg  Gln Gln Ala 
    2240                 2245                 2250             


Arg His  Leu Arg Trp Ala His  Pro Pro Ser Lys Ala  Gln Leu Arg 
    2255                 2260                 2265             


Gly Thr  Arg Gln Arg Met Arg  Arg Glu Ser Arg Thr  Arg Ala Ala 
    2270                 2275                 2280             


Leu Arg  Asp Ile Ser Met Asp  Ile Leu Met Leu Leu  Leu Leu Leu 
    2285                 2290                 2295             


Cys Val  Ile Tyr Gly Arg Phe  Ser Gln Asp Glu Tyr  Ser Leu Asn 
    2300                 2305                 2310             


Gln Ala  Ile Arg Lys Glu Phe  Thr Arg Asn Ala Arg  Asn Cys Leu 
    2315                 2320                 2325             


Gly Gly  Leu Arg Asn Ile Ala  Asp Trp Trp Asp Trp  Ser Leu Thr 
    2330                 2335                 2340             


Thr Leu  Leu Asp Gly Leu Tyr  Pro Gly Gly Thr Pro  Ser Ala Arg 
    2345                 2350                 2355             


Val Pro  Gly Ala Gln Pro Gly  Ala Leu Gly Gly Lys  Cys Tyr Leu 
    2360                 2365                 2370             


Ile Gly  Ser Ser Val Ile Arg  Gln Leu Lys Val Phe  Pro Arg His 
    2375                 2380                 2385             


Leu Cys  Lys Pro Pro Arg Pro  Phe Ser Ala Leu Ile  Glu Asp Ser 
    2390                 2395                 2400             


Ile Pro  Thr Cys Ser Pro Glu  Val Gly Gly Pro Glu  Asn Pro Tyr 
    2405                 2410                 2415             


Leu Ile  Asp Pro Glu Asn Gln  Asn Val Thr Leu Asn  Gly Pro Gly 
    2420                 2425                 2430             


Gly Cys  Gly Thr Arg Glu Asp  Cys Val Leu Ser Leu  Gly Arg Thr 
    2435                 2440                 2445             


Arg Thr  Glu Ala His Thr Ala  Leu Ser Arg Leu Arg  Ala Ser Met 
    2450                 2455                 2460             


Trp Ile  Asp Arg Ser Thr Arg  Ala Val Ser Val His  Phe Thr Leu 
    2465                 2470                 2475             


Tyr Asn  Pro Pro Thr Gln Leu  Phe Thr Ser Val Ser  Leu Arg Val 
    2480                 2485                 2490             


Glu Ile  Leu Pro Thr Gly Ser  Leu Val Pro Ser Ser  Leu Val Glu 
    2495                 2500                 2505             


Ser Phe  Ser Ile Phe Arg Ser  Asp Ser Ala Leu Gln  Tyr His Leu 
    2510                 2515                 2520             


Met Leu  Pro Gln Leu Val Phe  Leu Ala Leu Ser Leu  Ile His Leu 
    2525                 2530                 2535             


Cys Val  Gln Leu Tyr Arg Met  Met Asp Lys Gly Val  Leu Ser Tyr 
    2540                 2545                 2550             


Trp Arg  Lys Pro Arg Asn Trp  Leu Glu Leu Ser Val  Val Gly Val 
    2555                 2560                 2565             


Ser Leu  Thr Tyr Tyr Ala Val  Ser Gly His Leu Val  Thr Leu Ala 
    2570                 2575                 2580             


Gly Asp  Val Thr Asn Gln Phe  His Arg Gly Leu Cys  Arg Ala Phe 
    2585                 2590                 2595             


Met Asp  Leu Thr Leu Met Ala  Ser Trp Asn Gln Arg  Ala Arg Trp 
    2600                 2605                 2610             


Leu Arg  Gly Ile Leu Leu Phe  Leu Phe Thr Leu Lys  Cys Val Tyr 
    2615                 2620                 2625             


Leu Pro  Gly Ile Gln Asn Thr  Met Ala Ser Cys Ser  Ser Met Met 
    2630                 2635                 2640             


Arg His  Ser Leu Pro Ser Ile  Phe Val Ala Gly Leu  Val Gly Ala 
    2645                 2650                 2655             


Leu Met  Leu Ala Ala Leu Ser  His Leu His Arg Phe  Leu Leu Ser 
    2660                 2665                 2670             


Met Trp  Val Leu Pro Pro Gly  Thr Phe Thr Asp Ala  Phe Pro Gly 
    2675                 2680                 2685             


Leu Leu  Phe His Phe Pro Arg  Arg Ser Gln Lys Asp  Cys Leu Leu 
    2690                 2695                 2700             


Gly Leu  Ser Lys Ser Asp Gln  Arg Ala Met Ala Cys  Tyr Phe Gly 
    2705                 2710                 2715             


Ile Leu  Leu Ile Val Ser Ala  Thr Leu Cys Phe Gly  Met Leu Arg 
    2720                 2725                 2730             


Gly Phe  Leu Met Thr Leu Pro  Gln Lys Arg Lys Ser  Phe Gln Ser 
    2735                 2740                 2745             


Lys Ser  Phe Val Arg Leu Lys  Asp Val Thr Ala Tyr  Met Trp Glu 
    2750                 2755                 2760             


Lys Val  Leu Thr Phe Leu Arg  Leu Glu Thr Pro Lys  Leu Glu Glu 
    2765                 2770                 2775             


Ala Glu  Met Val Glu Asn His  Asn Tyr Tyr Leu Asp  Glu Phe Ala 
    2780                 2785                 2790             


Asn Leu  Leu Asp Glu Leu Leu  Met Lys Ile Asn Gly  Leu Ser Asp 
    2795                 2800                 2805             


Ser Leu  Gln Leu Pro Leu Leu  Glu Lys Thr Ser Asn  Asn Thr Gly 
    2810                 2815                 2820             


Glu Ala  Arg Thr Glu Glu Ser  Pro Leu Val Asp Ile  Ser Ser Tyr 
    2825                 2830                 2835             


Gln Ala  Ala Glu Pro Ala Asp  Ile Lys Asp Phe 
    2840                 2845                 


<210>  5721
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  5721

Met Ala Gly Thr Trp Leu Leu Leu Leu Leu Ala Leu Gly Cys Pro Ala 
1               5                   10                  15      


Leu Pro Thr Gly Val Gly Gly Thr Pro Phe Pro Ser Leu Ala Pro Pro 
            20                  25                  30          


Ile Met Leu Leu Val Asp Gly Lys Gln Gln Met Val Val Val Cys Leu 
        35                  40                  45              


Val Leu Asp Val Ala Pro Pro Gly Leu Asp Ser Pro Ile Trp Phe Ser 
    50                  55                  60                  


Ala Gly Asn Gly Ser Ala Leu Asp Ala Phe Thr Tyr Gly Pro Ser Pro 
65                  70                  75                  80  


Ala Thr Asp Gly Thr Trp Thr Asn Leu Ala His Leu Ser Leu Pro Ser 
                85                  90                  95      


Glu Glu Leu Ala Ser Trp Glu Pro Leu Val Cys His Thr Gly Pro Gly 
            100                 105                 110         


Ala Glu Gly His Ser Arg Ser Thr Gln Pro Met His Leu Ser Gly Glu 
        115                 120                 125             


Ala Ser Thr Ala Arg Thr Cys Pro Gln Glu Pro Leu Arg Gly Thr Pro 
    130                 135                 140                 


Gly Gly Ala Leu Trp Leu Gly Val Leu Arg Leu Leu Leu Phe Lys Leu 
145                 150                 155                 160 


Leu Leu Phe Asp Leu Leu Leu Thr Cys Ser Cys Leu Cys Asp Pro Ala 
                165                 170                 175     


Gly Pro Leu Pro Ser Pro Ala Thr Thr Thr Arg Leu Arg Ala Leu Gly 
            180                 185                 190         


Ser His Arg Leu His Pro Ala Thr Glu Thr Gly Gly Arg Glu Ala Thr 
        195                 200                 205             


Ser Ser Pro Arg Pro Gln Pro Arg Asp Arg Arg Trp Gly Asp Thr Pro 
    210                 215                 220                 


Pro Gly Arg Lys Pro Gly Ser Pro Val Trp Gly Glu Gly Ser Tyr Leu 
225                 230                 235                 240 


Ser Ser Tyr Pro Thr Cys Pro Ala Gln Ala Trp Cys Ser Arg Ser Ala 
                245                 250                 255     


Leu Arg Ala Pro Ser Ser Ser Leu Gly Ala Phe Phe Ala Gly Asp Leu 
            260                 265                 270         


Pro Pro Pro Leu Gln Ala Gly Ala Ala 
        275                 280     


<210>  5722
<211>  1125
<212>  PRT
<213>  Homo sapiens

<400>  5722

Met Lys Gly Ala Arg Trp Arg Arg Val Pro Trp Val Ser Leu Ser Cys 
1               5                   10                  15      


Leu Cys Leu Cys Leu Leu Pro His Val Val Pro Gly Val Ser Leu Phe 
            20                  25                  30          


Pro Tyr Gly Ala Gly Ala Gly Asp Leu Glu Phe Val Arg Arg Thr Val 
        35                  40                  45              


Asp Phe Thr Ser Pro Leu Phe Lys Pro Ala Thr Gly Phe Pro Leu Gly 
    50                  55                  60                  


Ser Ser Leu Arg Asp Ser Leu Tyr Phe Thr Asp Asn Gly Gln Ile Ile 
65                  70                  75                  80  


Phe Pro Glu Ser Asp Tyr Gln Ile Phe Ser Tyr Pro Asn Pro Leu Pro 
                85                  90                  95      


Thr Gly Phe Thr Gly Arg Asp Pro Val Ala Leu Val Ala Pro Phe Trp 
            100                 105                 110         


Asp Asp Ala Asp Phe Ser Thr Gly Arg Gly Thr Thr Phe Tyr Gln Glu 
        115                 120                 125             


Tyr Glu Thr Phe Tyr Gly Glu His Ser Leu Leu Val Gln Gln Ala Glu 
    130                 135                 140                 


Ser Trp Ile Arg Lys Met Thr Asn Asn Gly Gly Tyr Lys Ala Arg Trp 
145                 150                 155                 160 


Ala Leu Lys Val Thr Trp Val Asn Ala His Ala Tyr Pro Ala Gln Trp 
                165                 170                 175     


Thr Leu Gly Ser Asn Thr Tyr Gln Ala Ile Leu Ser Thr Asp Gly Ser 
            180                 185                 190         


Arg Ser Tyr Ala Leu Phe Leu Tyr Gln Ser Gly Gly Met Gln Trp Asp 
        195                 200                 205             


Val Ala Gln Arg Ser Gly Asn Pro Val Leu Met Gly Phe Ser Ser Gly 
    210                 215                 220                 


Asp Gly Tyr Phe Glu Asn Ser Pro Leu Met Ser Gln Pro Val Trp Glu 
225                 230                 235                 240 


Arg Tyr Arg Pro Asp Arg Phe Leu Asn Ser Asn Ser Gly Leu Gln Gly 
                245                 250                 255     


Leu Gln Phe Tyr Arg Leu His Arg Glu Glu Arg Pro Asn Tyr Arg Leu 
            260                 265                 270         


Glu Cys Leu Gln Trp Leu Lys Ser Gln Pro Arg Trp Pro Ser Trp Gly 
        275                 280                 285             


Trp Asn Gln Val Ser Cys Pro Cys Ser Trp Gln Gln Gly Arg Arg Asp 
    290                 295                 300                 


Leu Arg Phe Gln Pro Val Ser Ile Gly Arg Trp Gly Leu Gly Ser Arg 
305                 310                 315                 320 


Gln Leu Cys Ser Phe Thr Ser Trp Arg Gly Gly Val Cys Cys Ser Tyr 
                325                 330                 335     


Gly Pro Trp Gly Glu Phe Arg Glu Gly Trp His Val Gln Arg Pro Trp 
            340                 345                 350         


Gln Leu Ala Gln Glu Leu Glu Pro Gln Ser Trp Cys Cys Arg Trp Asn 
        355                 360                 365             


Asp Lys Pro Tyr Leu Cys Ala Leu Tyr Gln Gln Arg Arg Pro His Val 
    370                 375                 380                 


Gly Cys Ala Thr Tyr Arg Pro Pro Gln Pro Ala Trp Met Phe Gly Asp 
385                 390                 395                 400 


Pro His Ile Thr Thr Leu Asp Gly Val Ser Tyr Thr Phe Asn Gly Leu 
                405                 410                 415     


Gly Asp Phe Leu Leu Val Gly Ala Gln Asp Gly Asn Ser Ser Phe Leu 
            420                 425                 430         


Leu Gln Gly Arg Thr Ala Gln Thr Gly Ser Ala Gln Ala Thr Asn Phe 
        435                 440                 445             


Ile Ala Phe Ala Ala Gln Tyr Arg Ser Ser Ser Leu Gly Pro Val Thr 
    450                 455                 460                 


Val Gln Trp Leu Leu Glu Pro His Asp Ala Ile Arg Val Leu Leu Asp 
465                 470                 475                 480 


Asn Gln Thr Val Thr Phe Gln Pro Asp His Glu Asp Gly Gly Gly Gln 
                485                 490                 495     


Glu Thr Phe Asn Ala Thr Gly Val Leu Leu Ser Arg Asn Gly Ser Glu 
            500                 505                 510         


Val Ser Ala Ser Phe Asp Gly Trp Ala Thr Val Ser Val Ile Ala Leu 
        515                 520                 525             


Ser Asn Ile Leu His Ala Ser Ala Ser Leu Pro Pro Glu Tyr Gln Asn 
    530                 535                 540                 


Arg Thr Glu Gly Leu Leu Gly Val Trp Asn Asn Asn Pro Glu Asp Asp 
545                 550                 555                 560 


Phe Arg Met Pro Asn Gly Ser Thr Ile Pro Pro Gly Ser Pro Glu Glu 
                565                 570                 575     


Met Leu Phe His Phe Gly Met Thr Trp Gln Ile Asn Gly Thr Gly Leu 
            580                 585                 590         


Leu Gly Lys Arg Asn Asp Gln Leu Pro Ser Asn Phe Thr Pro Val Phe 
        595                 600                 605             


Tyr Ser Gln Leu Gln Lys Asn Ser Ser Trp Ala Glu His Leu Ile Ser 
    610                 615                 620                 


Asn Cys Asp Gly Asp Ser Ser Cys Ile Tyr Asp Thr Leu Ala Leu Arg 
625                 630                 635                 640 


Asn Ala Ser Ile Gly Leu His Thr Arg Glu Val Ser Lys Asn Tyr Glu 
                645                 650                 655     


Gln Ala Asn Ala Thr Leu Asn Gln Tyr Pro Pro Ser Ile Asn Gly Gly 
            660                 665                 670         


Arg Val Ile Glu Ala Tyr Lys Gly Gln Thr Thr Leu Ile Gln Tyr Thr 
        675                 680                 685             


Ser Asn Ala Glu Asp Ala Asn Phe Thr Leu Arg Asp Ser Cys Thr Asp 
    690                 695                 700                 


Leu Glu Leu Phe Glu Asn Gly Thr Leu Leu Trp Thr Pro Lys Ser Leu 
705                 710                 715                 720 


Glu Pro Phe Thr Leu Glu Ile Leu Ala Arg Ser Ala Lys Ile Gly Leu 
                725                 730                 735     


Ala Ser Ala Leu Gln Pro Arg Thr Val Val Cys His Cys Asn Ala Glu 
            740                 745                 750         


Ser Gln Cys Leu Tyr Asn Gln Thr Ser Arg Val Gly Asn Ser Ser Leu 
        755                 760                 765             


Glu Val Ala Gly Cys Lys Cys Asp Gly Gly Thr Phe Gly Arg Tyr Cys 
    770                 775                 780                 


Glu Gly Ser Glu Asp Ala Cys Glu Glu Pro Cys Phe Pro Ser Val His 
785                 790                 795                 800 


Cys Val Pro Gly Lys Gly Cys Glu Ala Cys Pro Pro Asn Leu Thr Gly 
                805                 810                 815     


Asp Gly Arg His Cys Ala Ala Leu Gly Ser Ser Phe Leu Cys Gln Asn 
            820                 825                 830         


Gln Ser Cys Pro Val Asn Tyr Cys Tyr Asn Gln Gly His Cys Tyr Ile 
        835                 840                 845             


Ser Gln Thr Leu Gly Cys Gln Pro Met Cys Thr Cys Pro Pro Ala Phe 
    850                 855                 860                 


Thr Asp Ser Arg Cys Phe Leu Ala Gly Asn Asn Phe Ser Pro Thr Val 
865                 870                 875                 880 


Asn Leu Glu Leu Pro Leu Arg Val Ile Gln Leu Leu Leu Ser Glu Glu 
                885                 890                 895     


Glu Asn Ala Ser Met Ala Glu Val Asn Ala Ser Val Ala Tyr Arg Leu 
            900                 905                 910         


Gly Thr Leu Asp Met Arg Ala Phe Leu Arg Asn Ser Gln Val Glu Arg 
        915                 920                 925             


Ile Asp Ser Ala Ala Pro Ala Ser Gly Ser Pro Ile Gln His Trp Met 
    930                 935                 940                 


Val Ile Ser Glu Phe Gln Tyr Arg Pro Arg Gly Pro Val Ile Asp Phe 
945                 950                 955                 960 


Leu Asn Asn Gln Leu Leu Ala Ala Val Val Glu Ala Phe Leu Tyr His 
                965                 970                 975     


Val Pro Arg Arg Ser Glu Glu Pro Arg Asn Asp Val Val Phe Gln Pro 
            980                 985                 990         


Ile Ser Gly Glu Asp Val Arg Asp  Val Thr Ala Leu Asn  Val Ser Thr 
        995                 1000                 1005             


Leu Lys  Ala Tyr Phe Arg Cys  Asp Gly Tyr Lys Gly  Tyr Asp Leu 
    1010                 1015                 1020             


Val Tyr  Ser Pro Gln Ser Gly  Phe Thr Cys Val Ser  Pro Cys Ser 
    1025                 1030                 1035             


Arg Gly  Tyr Cys Asp His Gly  Gly Gln Cys Gln His  Leu Pro Ser 
    1040                 1045                 1050             


Gly Pro  Arg Cys Ser Cys Val  Ser Phe Ser Ile Tyr  Thr Ala Trp 
    1055                 1060                 1065             


Gly Glu  His Cys Glu His Leu  Ser Met Lys Leu Asp  Ala Phe Phe 
    1070                 1075                 1080             


Gly Ile  Phe Phe Gly Ala Leu  Gly Gly Leu Leu Leu  Leu Gly Val 
    1085                 1090                 1095             


Gly Thr  Phe Val Val Leu Arg  Phe Trp Gly Cys Ser  Gly Ala Arg 
    1100                 1105                 1110             


Phe Ser  Tyr Phe Leu Asn Ser  Ala Glu Ala Leu Pro  
    1115                 1120                 1125 


<210>  5723
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  5723

Met Lys Phe Pro Ile Glu Thr Pro Arg Lys Gln Val Asn Trp Asp Pro 
1               5                   10                  15      


Lys Val Ala Val Pro Ala Ala Ala Pro Val Cys Gln Pro Lys Ser Ala 
            20                  25                  30          


Thr Asn Gly Gln Pro Pro Ala Pro Ala Pro Thr Pro Thr Pro Arg Leu 
        35                  40                  45              


Ser Ile Ser Ser Arg Ala Thr Val Val Ala Arg Met Glu Gly Thr Ser 
    50                  55                  60                  


Gln Gly Gly Leu Gln Thr Val Met Lys Trp Lys Thr Val Val Ala Ile 
65                  70                  75                  80  


Phe Val Val Val Val Val Tyr Leu Val Thr Gly Gly Leu Val Phe Arg 
                85                  90                  95      


Ala Leu Glu Gln Pro Phe Glu Ser Ser Gln Lys Asn Thr Ile Ala Leu 
            100                 105                 110         


Glu Lys Ala Glu Phe Leu Arg Asp His Val Cys Val Ser Pro Gln Glu 
        115                 120                 125             


Leu Glu Thr Leu Ile Gln His Ala Leu Asp Ala Asp Asn Ala Gly Val 
    130                 135                 140                 


Ser Pro Ile Gly Asn Ser Ser Asn Asn Ser Ser His Trp Asp Leu Gly 
145                 150                 155                 160 


Ser Ala Phe Phe Phe Ala Gly Thr Val Ile Thr Thr Ile Gly Tyr Gly 
                165                 170                 175     


Asn Ile Ala Pro Ser Thr Glu Gly Gly Lys Ile Phe Cys Ile Leu Tyr 
            180                 185                 190         


Ala Ile Phe Gly Ile Pro Leu Phe Gly Phe Leu Leu Ala Gly Ile Gly 
        195                 200                 205             


Asp Gln Leu Gly Thr Ile Phe Gly Lys Ser Ile Ala Arg Val Glu Lys 
    210                 215                 220                 


Val Phe Arg Lys Lys Gln Val Ser Gln Thr Lys Ile Arg Val Ile Ser 
225                 230                 235                 240 


Thr Ile Leu Phe Ile Leu Ala Gly Cys Ile Val Phe Val Thr Ile Pro 
                245                 250                 255     


Ala Val Ile Phe Lys Tyr Ile Glu Gly Trp Thr Ala Leu Glu Ser Ile 
            260                 265                 270         


Tyr Phe Val Val Val Thr Leu Thr Thr Val Gly Phe Gly Asp Phe Val 
        275                 280                 285             


Ala Gly Gly Asn Ala Gly Ile Asn Tyr Arg Glu Trp Tyr Lys Pro Leu 
    290                 295                 300                 


Val Trp Phe Trp Ile Leu Val Gly Leu Ala Tyr Phe Ala Ala Val Leu 
305                 310                 315                 320 


Ser Met Ile Gly Asp Trp Leu Arg Val Leu Ser Lys Lys Thr Lys Glu 
                325                 330                 335     


Glu Val Gly Glu Ile Lys Ala His Ala Ala Glu Trp Lys Ala Asn Val 
            340                 345                 350         


Thr Ala Glu Phe Arg Glu Thr Arg Arg Arg Leu Ser Val Glu Ile His 
        355                 360                 365             


Asp Lys Leu Gln Arg Ala Ala Thr Ile Arg Ser Met Glu Arg Arg Arg 
    370                 375                 380                 


Leu Gly Leu Asp Gln Arg Ala His Ser Leu Asp Met Leu Ser Pro Glu 
385                 390                 395                 400 


Lys Arg Ser Val Phe Ala Ala Leu Asp Thr Gly Arg Phe Lys Ala Ser 
                405                 410                 415     


Ser Gln Glu Ser Ile Asn Asn Arg Pro Asn Asn Leu Arg Leu Lys Gly 
            420                 425                 430         


Pro Glu Gln Leu Asn Lys His Gly Gln Gly Ala Ser Glu Asp Asn Ile 
        435                 440                 445             


Ile Asn Lys Phe Gly Ser Thr Ser Arg Leu Thr Lys Arg Lys Asn Lys 
    450                 455                 460                 


Asp Leu Lys Lys Thr Leu Pro Glu Asp Val Gln Lys Ile Tyr Lys Thr 
465                 470                 475                 480 


Phe Arg Asn Tyr Ser Leu Asp Glu Glu Lys Lys Glu Glu Glu Thr Glu 
                485                 490                 495     


Lys Met Cys Asn Ser Asp Asn Ser Ser Thr Ala Met Leu Thr Asp Cys 
            500                 505                 510         


Ile Gln Gln His Ala Glu Leu Glu Asn Gly Met Ile Pro Thr Asp Thr 
        515                 520                 525             


Lys Asp Arg Glu Pro Glu Asn Asn Ser Leu Leu Glu Asp Arg Asn 
    530                 535                 540             


<210>  5724
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  5724

Met Glu Asp Gly Phe Lys Gly Asp Arg Thr Glu Gly Cys Arg Ser Asp 
1               5                   10                  15      


Ser Val Ala Val Pro Ala Ala Ala Pro Val Cys Gln Pro Lys Ser Ala 
            20                  25                  30          


Thr Asn Gly Gln Pro Pro Ala Pro Ala Pro Thr Pro Thr Pro Arg Leu 
        35                  40                  45              


Ser Ile Ser Ser Arg Ala Thr Val Val Ala Arg Met Glu Gly Thr Ser 
    50                  55                  60                  


Gln Gly Gly Leu Gln Thr Val Met Lys Trp Lys Thr Val Val Ala Ile 
65                  70                  75                  80  


Phe Val Val Val Val Val Tyr Leu Val Thr Gly Gly Leu Val Phe Arg 
                85                  90                  95      


Ala Leu Glu Gln Pro Phe Glu Ser Ser Gln Lys Asn Thr Ile Ala Leu 
            100                 105                 110         


Glu Lys Ala Glu Phe Leu Arg Asp His Val Cys Val Ser Pro Gln Glu 
        115                 120                 125             


Leu Glu Thr Leu Ile Gln His Ala Leu Asp Ala Asp Asn Ala Gly Val 
    130                 135                 140                 


Ser Pro Ile Gly Asn Ser Ser Asn Asn Ser Ser His Trp Asp Leu Gly 
145                 150                 155                 160 


Ser Ala Phe Phe Phe Ala Gly Thr Val Ile Thr Thr Ile Gly Tyr Gly 
                165                 170                 175     


Asn Ile Ala Pro Ser Thr Glu Gly Gly Lys Ile Phe Cys Ile Leu Tyr 
            180                 185                 190         


Ala Ile Phe Gly Ile Pro Leu Phe Gly Phe Leu Leu Ala Gly Ile Gly 
        195                 200                 205             


Asp Gln Leu Gly Thr Ile Phe Gly Lys Ser Ile Ala Arg Val Glu Lys 
    210                 215                 220                 


Val Phe Arg Lys Lys Gln Val Ser Gln Thr Lys Ile Arg Val Ile Ser 
225                 230                 235                 240 


Thr Ile Leu Phe Ile Leu Ala Gly Cys Ile Val Phe Val Thr Ile Pro 
                245                 250                 255     


Ala Val Ile Phe Lys Tyr Ile Glu Gly Trp Thr Ala Leu Glu Ser Ile 
            260                 265                 270         


Tyr Phe Val Val Val Thr Leu Thr Thr Val Gly Phe Gly Asp Phe Val 
        275                 280                 285             


Ala Gly Gly Asn Ala Gly Ile Asn Tyr Arg Glu Trp Tyr Lys Pro Leu 
    290                 295                 300                 


Val Trp Phe Trp Ile Leu Val Gly Leu Ala Tyr Phe Ala Ala Val Leu 
305                 310                 315                 320 


Ser Met Ile Gly Asp Trp Leu Arg Val Leu Ser Lys Lys Thr Lys Glu 
                325                 330                 335     


Glu Val Gly Glu Ile Lys Ala His Ala Ala Glu Trp Lys Ala Asn Val 
            340                 345                 350         


Thr Ala Glu Phe Arg Glu Thr Arg Arg Arg Leu Ser Val Glu Ile His 
        355                 360                 365             


Asp Lys Leu Gln Arg Ala Ala Thr Ile Arg Ser Met Glu Arg Arg Arg 
    370                 375                 380                 


Leu Gly Leu Asp Gln Arg Ala His Ser Leu Asp Met Leu Ser Pro Glu 
385                 390                 395                 400 


Lys Arg Ser Val Phe Ala Ala Leu Asp Thr Gly Arg Phe Lys Ala Ser 
                405                 410                 415     


Ser Gln Glu Ser Ile Asn Asn Arg Pro Asn Asn Leu Arg Leu Lys Gly 
            420                 425                 430         


Pro Glu Gln Leu Asn Lys His Gly Gln Gly Ala Ser Glu Asp Asn Ile 
        435                 440                 445             


Ile Asn Lys Phe Gly Ser Thr Ser Arg Leu Thr Lys Arg Lys Asn Lys 
    450                 455                 460                 


Asp Leu Lys Lys Thr Leu Pro Glu Asp Val Gln Lys Ile Tyr Lys Thr 
465                 470                 475                 480 


Phe Arg Asn Tyr Ser Leu Asp Glu Glu Lys Lys Glu Glu Glu Thr Glu 
                485                 490                 495     


Lys Met Cys Asn Ser Asp Asn Ser Ser Thr Ala Met Leu Thr Asp Cys 
            500                 505                 510         


Ile Gln Gln His Ala Glu Leu Glu Asn Gly Met Ile Pro Thr Asp Thr 
        515                 520                 525             


Lys Asp Arg Glu Pro Glu Asn Asn Ser Leu Leu Glu Asp Arg Asn 
    530                 535                 540             


<210>  5725
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  5725

Met Lys Ile Asp Ile His Ser His Ile Leu Pro Lys Glu Trp Pro Asp 
1               5                   10                  15      


Leu Lys Lys Arg Phe Gly Tyr Gly Gly Trp Val Gln Leu Gln His His 
            20                  25                  30          


Ser Lys Gly Glu Ala Lys Leu Leu Lys Asp Gly Lys Val Phe Arg Val 
        35                  40                  45              


Val Arg Glu Asn Cys Trp Asp Pro Glu Val Arg Ile Arg Glu Met Asp 
    50                  55                  60                  


Gln Lys Gly Val Thr Val Gln Ala Leu Ser Thr Val Pro Val Met Phe 
65                  70                  75                  80  


Ser Tyr Trp Ala Lys Pro Glu Asp Thr Leu Asn Leu Cys Gln Leu Leu 
                85                  90                  95      


Asn Asn Asp Leu Ala Ser Thr Val Val Ser Tyr Pro Arg Arg Phe Val 
            100                 105                 110         


Gly Leu Gly Thr Leu Pro Met Gln Ala Pro Glu Leu Ala Val Lys Glu 
        115                 120                 125             


Met Glu Arg Cys Val Lys Glu Leu Gly Phe Pro Gly Val Gln Ile Gly 
    130                 135                 140                 


Thr His Val Asn Glu Trp Asp Leu Asn Ala Gln Glu Leu Phe Pro Val 
145                 150                 155                 160 


Tyr Ala Ala Ala Glu Arg Leu Lys Cys Ser Leu Phe Val His Pro Trp 
                165                 170                 175     


Asp Met Gln Met Asp Gly Arg Met Ala Lys Tyr Trp Leu Pro Trp Leu 
            180                 185                 190         


Val Gly Met Pro Ala Glu Thr Thr Ile Ala Ile Cys Ser Met Ile Met 
        195                 200                 205             


Gly Gly Val Phe Glu Lys Phe Pro Lys Leu Lys Val Cys Phe Ala His 
    210                 215                 220                 


Gly Gly Gly Ala Phe Pro Phe Thr Val Gly Arg Ile Ser His Gly Phe 
225                 230                 235                 240 


Ser Met Arg Pro Asp Leu Cys Ala Gln Asp Asn Pro Met Asn Pro Lys 
                245                 250                 255     


Lys Tyr Leu Gly Ser Phe Tyr Thr Asp Ala Leu Val His Asp Pro Leu 
            260                 265                 270         


Ser Leu Lys Leu Leu Thr Asp Val Ile Gly Lys Asp Lys Val Ile Leu 
        275                 280                 285             


Gly Thr Asp Tyr Pro Phe Pro Leu Gly Glu Leu Glu Pro Gly Lys Leu 
    290                 295                 300                 


Ile Glu Ser Met Glu Glu Phe Asp Glu Glu Thr Lys Asn Lys Leu Lys 
305                 310                 315                 320 


Ala Gly Asn Ala Leu Ala Phe Leu Gly Leu Glu Arg Lys Gln Phe Glu 
                325                 330                 335     


<210>  5726
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  5726

Met Met Pro Phe Cys His Asn Ile Ile Asn Ile Ser Cys Val Lys Asn 
1               5                   10                  15      


Asn Trp Ser Asn Asp Val Arg Ala Ser Leu Tyr Ser Leu Met Val Leu 
            20                  25                  30          


Ile Ile Leu Thr Thr Leu Val Gly Asn Leu Ile Val Ile Val Ser Ile 
        35                  40                  45              


Ser His Phe Lys Gln Leu His Thr Pro Thr Asn Trp Leu Ile His Ser 
    50                  55                  60                  


Met Ala Thr Val Asp Phe Leu Leu Gly Cys Leu Val Met Pro Tyr Ser 
65                  70                  75                  80  


Met Val Arg Ser Ala Glu His Cys Trp Tyr Phe Gly Glu Val Phe Cys 
                85                  90                  95      


Lys Ile His Thr Ser Thr Asp Ile Met Leu Ser Ser Ala Ser Ile Phe 
            100                 105                 110         


His Leu Ser Phe Ile Ser Ile Asp Arg Tyr Tyr Ala Val Cys Asp Pro 
        115                 120                 125             


Leu Arg Tyr Lys Ala Lys Met Asn Ile Leu Val Ile Cys Val Met Ile 
    130                 135                 140                 


Phe Ile Ser Trp Ser Val Pro Ala Val Phe Ala Phe Gly Met Ile Phe 
145                 150                 155                 160 


Leu Glu Leu Asn Phe Lys Gly Ala Glu Glu Ile Tyr Tyr Lys His Val 
                165                 170                 175     


His Cys Arg Gly Gly Cys Ser Val Phe Phe Ser Lys Ile Ser Gly Val 
            180                 185                 190         


Leu Thr Phe Met Thr Ser Phe Tyr Ile Pro Gly Ser Ile Met Leu Cys 
        195                 200                 205             


Val Tyr Tyr Arg Ile Tyr Leu Ile Ala Lys Glu Gln Ala Arg Leu Ile 
    210                 215                 220                 


Ser Asp Ala Asn Gln Lys Leu Gln Ile Gly Leu Glu Met Lys Asn Gly 
225                 230                 235                 240 


Ile Ser Gln Ser Lys Glu Arg Lys Ala Val Lys Thr Leu Gly Ile Val 
                245                 250                 255     


Met Gly Val Phe Leu Ile Cys Trp Cys Pro Phe Phe Ile Cys Thr Val 
            260                 265                 270         


Met Asp Pro Phe Leu His Tyr Ile Ile Pro Pro Thr Leu Asn Asp Val 
        275                 280                 285             


Leu Ile Trp Phe Gly Tyr Leu Asn Ser Thr Phe Asn Pro Met Val Tyr 
    290                 295                 300                 


Ala Phe Phe Tyr Pro Trp Phe Arg Lys Ala Leu Lys Met Met Leu Phe 
305                 310                 315                 320 


Gly Lys Ile Phe Gln Lys Asp Ser Ser Arg Cys Lys Leu Phe Leu Glu 
                325                 330                 335     


Leu Ser Ser 
            


<210>  5727
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  5727

Met Gly Glu His Pro Ser Pro Gly Pro Ala Val Ala Ala Cys Ala Glu 
1               5                   10                  15      


Ala Glu Arg Ile Glu Glu Leu Glu Pro Glu Ala Glu Glu Arg Leu Pro 
            20                  25                  30          


Ala Ala Pro Glu Asp His Trp Lys Val Leu Phe Asp Gln Phe Asp Pro 
        35                  40                  45              


Gly Asn Thr Gly Tyr Ile Ser Thr Gly Lys Phe Arg Ser Leu Leu Glu 
    50                  55                  60                  


Ser His Ser Ser Lys Leu Asp Pro His Lys Arg Glu Val Leu Leu Ala 
65                  70                  75                  80  


Leu Ala Asp Ser His Ala Asp Gly Gln Ile Gly Tyr Gln Asp Phe Val 
                85                  90                  95      


Ser Leu Met Ser Asn Lys Arg Ser Asn Ser Phe Arg Gln Ala Ile Leu 
            100                 105                 110         


Gln Gly Asn Arg Arg Leu Ser Ser Lys Ala Leu Leu Glu Glu Lys Gly 
        115                 120                 125             


Leu Ser Leu Ser Gln Arg Leu Ile Arg His Val Ala Tyr Glu Thr Leu 
    130                 135                 140                 


Pro Arg Glu Ile Asp Arg Lys Trp Tyr Tyr Asp Ser Tyr Thr Cys Cys 
145                 150                 155                 160 


Pro Pro Pro Trp Phe Met Ile Thr Val Thr Leu Leu Glu Val Ala Phe 
                165                 170                 175     


Phe Leu Tyr Asn Gly Val Ser Leu Gly Gln Phe Val Leu Gln Val Thr 
            180                 185                 190         


His Pro Arg Tyr Leu Lys Asn Ser Leu Val Tyr His Pro Gln Leu Arg 
        195                 200                 205             


Ala Gln Val Trp Arg Tyr Leu Thr Tyr Ile Phe Met His Ala Gly Ile 
    210                 215                 220                 


Glu His Leu Gly Leu Asn Val Val Leu Gln Leu Leu Val Gly Val Pro 
225                 230                 235                 240 


Leu Glu Met Val His Gly Ala Thr Arg Ile Gly Leu Val Tyr Val Ala 
                245                 250                 255     


Gly Val Val Ala Gly Ser Leu Ala Val Ser Val Ala Asp Met Thr Ala 
            260                 265                 270         


Pro Val Val Gly Ser Ser Gly Gly Val Tyr Ala Leu Val Ser Ala His 
        275                 280                 285             


Leu Ala Asn Ile Val Met Asn Trp Ser Gly Met Lys Cys Gln Phe Lys 
    290                 295                 300                 


Leu Leu Arg Met Ala Val Ala Leu Ile Cys Met Ser Met Glu Phe Gly 
305                 310                 315                 320 


Arg Ala Val Trp Leu Arg Phe His Pro Ser Ala Tyr Pro Pro Cys Pro 
                325                 330                 335     


His Pro Ser Phe Val Ala His Leu Gly Gly Val Ala Val Gly Ile Thr 
            340                 345                 350         


Leu Gly Val Val Val Leu Arg Asn Tyr Glu Gln Arg Leu Gln Asp Gln 
        355                 360                 365             


Ser Leu Trp Trp Ile Phe Val Ala Met Tyr Thr Val Phe Val Leu Phe 
    370                 375                 380                 


Ala Val Phe Trp Asn Ile Phe Ala Tyr Thr Leu Leu Asp Leu Lys Leu 
385                 390                 395                 400 


Pro Pro Pro Pro 
                


<210>  5728
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  5728

Met Ser Glu Glu Val Thr Tyr Ala Asp Leu Gln Phe Gln Asn Ser Ser 
1               5                   10                  15      


Glu Met Glu Lys Ile Pro Glu Ile Gly Lys Phe Gly Glu Lys Ala Pro 
            20                  25                  30          


Pro Ala Pro Ser His Val Trp Arg Pro Ala Ala Leu Phe Leu Thr Leu 
        35                  40                  45              


Leu Cys Leu Leu Leu Leu Ile Gly Leu Gly Val Leu Ala Ser Met Phe 
    50                  55                  60                  


His Val Thr Leu Lys Ile Glu Met Lys Lys Met Asn Lys Leu Gln Asn 
65                  70                  75                  80  


Ile Ser Glu Glu Leu Gln Arg Asn Ile Ser Leu Gln Leu Met Ser Asn 
                85                  90                  95      


Met Asn Ile Ser Asn Lys Ile Arg Asn Leu Ser Thr Thr Leu Gln Thr 
            100                 105                 110         


Ile Ala Thr Lys Leu Cys Arg Glu Leu Tyr Ser Lys Glu Gln Glu His 
        115                 120                 125             


Lys Cys Lys Pro Cys Pro Arg Arg Trp Ile Trp His Lys Asp Ser Cys 
    130                 135                 140                 


Tyr Phe Leu Ser Asp Asp Val Gln Thr Trp Gln Glu Ser Lys Met Ala 
145                 150                 155                 160 


Cys Ala Ala Gln Asn Ala Ser Leu Leu Lys Ile Asn Asn Lys Asn Ala 
                165                 170                 175     


Leu Glu Phe Ile Lys Ser Gln Ser Arg Ser Tyr Asp Tyr Trp Leu Gly 
            180                 185                 190         


Leu Ser Pro Glu Glu Asp Ser Thr Arg Gly Met Arg Val Asp Asn Ile 
        195                 200                 205             


Ile Asn Ser Ser Ala Trp Val Ile Arg Asn Ala Pro Asp Leu Asn Asn 
    210                 215                 220                 


Met Tyr Cys Gly Tyr Ile Asn Arg Leu Tyr Val Gln Tyr Tyr His Cys 
225                 230                 235                 240 


Thr Tyr Lys Lys Arg Met Ile Cys Glu Lys Met Ala Asn Pro Val Gln 
                245                 250                 255     


Leu Gly Ser Thr Tyr Phe Arg Glu Ala 
            260                 265 


<210>  5729
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  5729

Met Ser Glu Glu Val Thr Tyr Ala Thr Leu Thr Phe Gln Asp Ser Ala 
1               5                   10                  15      


Gly Ala Arg Asn Asn Arg Asp Gly Asn Asn Leu Arg Lys Arg Gly His 
            20                  25                  30          


Pro Ala Pro Ser Pro Ile Trp Arg His Ala Ala Leu Gly Leu Val Thr 
        35                  40                  45              


Leu Cys Leu Met Leu Leu Ile Gly Leu Val Thr Leu Gly Met Met Phe 
    50                  55                  60                  


Leu Gln Ile Ser Asn Asp Ile Asn Ser Asp Ser Glu Lys Leu Ser Gln 
65                  70                  75                  80  


Leu Gln Lys Thr Ile Gln Gln Gln Gln Asp Asn Leu Ser Gln Gln Leu 
                85                  90                  95      


Gly Asn Ser Asn Asn Leu Ser Met Glu Glu Glu Phe Leu Lys Ser Gln 
            100                 105                 110         


Ile Ser Ser Val Leu Lys Arg Gln Glu Gln Met Ala Ile Lys Leu Cys 
        115                 120                 125             


Gln Glu Leu Ile Ile His Thr Ser Asp His Arg Cys Asn Pro Cys Pro 
    130                 135                 140                 


Lys Met Trp Gln Trp Tyr Gln Asn Ser Cys Tyr Tyr Phe Thr Thr Asn 
145                 150                 155                 160 


Glu Glu Lys Thr Trp Ala Asn Ser Arg Lys Asp Cys Ile Asp Lys Asn 
                165                 170                 175     


Ser Thr Leu Val Lys Ile Asp Ser Leu Glu Glu Lys Asp Phe Leu Met 
            180                 185                 190         


Ser Gln Pro Leu Leu Met Phe Ser Phe Phe Trp Leu Gly Leu Ser Trp 
        195                 200                 205             


Asp Ser Ser Gly Arg Ser Trp Phe Trp Glu Asp Gly Ser Val Pro Ser 
    210                 215                 220                 


Pro Ser Leu Phe Ser Thr Lys Glu Leu Asp Gln Ile Asn Gly Ser Lys 
225                 230                 235                 240 


Gly Cys Ala Tyr Phe Gln Lys Gly Asn Ile Tyr Ile Ser Arg Cys Ser 
                245                 250                 255     


Ala Glu Ile Phe Trp Ile Cys Glu Lys Thr Ala Ala Pro Val Lys Thr 
            260                 265                 270         


Glu Asp Leu Asp 
        275     


<210>  5730
<211>  409
<212>  PRT
<213>  Homo sapiens

<400>  5730

Met Gln Arg Leu Ala Met Asp Leu Arg Met Leu Ser Arg Glu Leu Ser 
1               5                   10                  15      


Leu Tyr Leu Glu His Gln Val Arg Val Gly Phe Phe Gly Ser Gly Val 
            20                  25                  30          


Gly Leu Ser Leu Ile Leu Gly Phe Ser Val Ala Tyr Ala Phe Tyr Tyr 
        35                  40                  45              


Leu Ser Ser Ile Ala Lys Lys Pro Gln Leu Val Thr Gly Gly Glu Ser 
    50                  55                  60                  


Phe Ser Arg Phe Leu Gln Asp His Cys Pro Val Val Thr Glu Thr Tyr 
65                  70                  75                  80  


Tyr Pro Thr Val Trp Cys Trp Glu Gly Arg Gly Gln Thr Leu Leu Arg 
                85                  90                  95      


Pro Phe Ile Thr Ser Lys Pro Pro Val Gln Tyr Arg Asn Glu Leu Ile 
            100                 105                 110         


Lys Thr Ala Asp Gly Gly Gln Ile Ser Leu Asp Trp Phe Asp Asn Asp 
        115                 120                 125             


Asn Ser Thr Cys Tyr Met Asp Ala Ser Thr Arg Pro Thr Ile Leu Leu 
    130                 135                 140                 


Leu Pro Gly Leu Thr Gly Thr Ser Lys Glu Ser Tyr Ile Leu His Met 
145                 150                 155                 160 


Ile His Leu Ser Glu Glu Leu Gly Tyr Arg Cys Val Val Phe Asn Asn 
                165                 170                 175     


Arg Gly Val Ala Gly Glu Asn Leu Leu Thr Pro Arg Thr Tyr Cys Cys 
            180                 185                 190         


Ala Asn Thr Glu Asp Leu Glu Thr Val Ile His His Val His Ser Leu 
        195                 200                 205             


Tyr Pro Ser Ala Pro Phe Leu Ala Ala Gly Val Ser Met Gly Gly Met 
    210                 215                 220                 


Leu Leu Leu Asn Tyr Leu Gly Lys Ile Gly Ser Lys Thr Pro Leu Met 
225                 230                 235                 240 


Ala Ala Ala Thr Phe Ser Val Gly Trp Asn Thr Phe Ala Cys Ser Glu 
                245                 250                 255     


Ser Leu Glu Lys Pro Leu Asn Trp Leu Leu Phe Asn Tyr Tyr Leu Thr 
            260                 265                 270         


Thr Cys Leu Gln Ser Ser Val Asn Lys His Arg His Met Phe Val Lys 
        275                 280                 285             


Gln Val Asp Met Asp His Val Met Lys Ala Lys Ser Ile Arg Glu Phe 
    290                 295                 300                 


Asp Lys Arg Phe Thr Ser Val Met Phe Gly Tyr Gln Thr Ile Asp Asp 
305                 310                 315                 320 


Tyr Tyr Thr Asp Ala Ser Pro Ser Pro Arg Leu Lys Ser Val Gly Ile 
                325                 330                 335     


Pro Val Leu Cys Leu Asn Ser Val Asp Asp Val Phe Ser Pro Ser His 
            340                 345                 350         


Ala Ile Pro Ile Glu Thr Ala Lys Gln Asn Pro Asn Val Ala Leu Val 
        355                 360                 365             


Leu Thr Ser Tyr Gly Gly His Ile Gly Phe Leu Glu Gly Ile Trp Pro 
    370                 375                 380                 


Arg Gln Ser Thr Tyr Met Asp Arg Val Phe Lys Gln Phe Val Gln Ala 
385                 390                 395                 400 


Met Val Glu His Gly His Glu Leu Ser 
                405                 


<210>  5731
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  5731

Met Lys His Thr Gln Ser Gly Gln Ser Thr Ser Pro Leu Val Ile Asp 
1               5                   10                  15      


Tyr Thr Cys Arg Val Cys Gln Met Ala Phe Val Phe Ser Ser Leu Ile 
            20                  25                  30          


Pro Leu Leu Leu Met Thr Pro Val Phe Cys Leu Gly Asn Thr Ser Glu 
        35                  40                  45              


Cys Phe Gln Asn Phe Ser Gln Ser His Lys Cys Ile Leu Met His Ser 
    50                  55                  60                  


Pro Pro Ser Ala Met Ala Glu Leu Pro Pro Ser Ala Asn Thr Ser Val 
65                  70                  75                  80  


Cys Ser Thr Leu Tyr Phe Tyr Gly Ile Ala Ile Phe Leu Gly Ser Phe 
                85                  90                  95      


Val Leu Ser Leu Leu Thr Ile Met Val Leu Leu Ile Arg Ala Gln Thr 
            100                 105                 110         


Leu Tyr Lys Lys Phe Val Lys Ser Thr Gly Phe Leu Gly Ser Glu Gln 
        115                 120                 125             


Trp Ala Val Ile His Ile Val Asp Gln Arg Val Arg Phe Tyr Pro Val 
    130                 135                 140                 


Ala Phe Phe Cys Cys Trp Gly Pro Ala Val Ile Leu Met Ile Ile Lys 
145                 150                 155                 160 


Leu Thr Lys Pro Gln Asp Thr Lys Leu His Met Ala Leu Tyr Val Leu 
                165                 170                 175     


Gln Ala Leu Thr Ala Thr Ser Gln Gly Leu Leu Asn Cys Gly Val Tyr 
            180                 185                 190         


Gly Trp Thr Gln His Lys Phe His Gln Leu Lys Gln Glu Ala Arg Arg 
        195                 200                 205             


Asp Ala Asp Thr Gln Thr Pro Leu Leu Cys Ser Gln Lys Arg Phe Tyr 
    210                 215                 220                 


Ser Arg Gly Leu Asn Ser Leu Glu Ser Thr Leu Thr Phe Pro Ala Ser 
225                 230                 235                 240 


Thr Ser Thr Ile Phe 
                245 


<210>  5732
<211>  636
<212>  PRT
<213>  Homo sapiens

<400>  5732

Met Thr Thr Trp Ser Leu Arg Arg Arg Pro Ala Arg Thr Leu Gly Leu 
1               5                   10                  15      


Leu Leu Leu Val Val Leu Gly Phe Leu Val Leu Arg Arg Leu Asp Trp 
            20                  25                  30          


Ser Thr Leu Val Pro Leu Arg Leu Arg His Arg Gln Leu Gly Leu Gln 
        35                  40                  45              


Ala Lys Gly Trp Asn Phe Met Leu Glu Asp Ser Thr Phe Trp Ile Phe 
    50                  55                  60                  


Gly Gly Ser Ile His Tyr Phe Arg Val Pro Arg Glu Tyr Trp Arg Asp 
65                  70                  75                  80  


Arg Leu Leu Lys Met Lys Ala Cys Gly Leu Asn Thr Leu Thr Thr Tyr 
                85                  90                  95      


Val Pro Trp Asn Leu His Glu Pro Glu Arg Gly Lys Phe Asp Phe Ser 
            100                 105                 110         


Gly Asn Leu Asp Leu Glu Ala Phe Val Leu Met Ala Ala Glu Ile Gly 
        115                 120                 125             


Leu Trp Val Ile Leu Arg Pro Gly Pro Tyr Ile Cys Ser Glu Met Asp 
    130                 135                 140                 


Leu Gly Gly Leu Pro Ser Trp Leu Leu Gln Asp Pro Gly Met Arg Leu 
145                 150                 155                 160 


Arg Thr Thr Tyr Lys Gly Phe Thr Glu Ala Val Asp Leu Tyr Phe Asp 
                165                 170                 175     


His Leu Met Ser Arg Val Val Pro Leu Gln Tyr Lys Arg Gly Gly Pro 
            180                 185                 190         


Ile Ile Ala Val Gln Val Glu Asn Glu Tyr Gly Ser Tyr Asn Lys Asp 
        195                 200                 205             


Pro Ala Tyr Met Pro Tyr Val Lys Lys Ala Leu Glu Asp Arg Gly Ile 
    210                 215                 220                 


Val Glu Leu Leu Leu Thr Ser Asp Asn Lys Asp Gly Leu Ser Lys Gly 
225                 230                 235                 240 


Ile Val Gln Gly Val Leu Ala Thr Ile Asn Leu Gln Ser Thr His Glu 
                245                 250                 255     


Leu Gln Leu Leu Thr Thr Phe Leu Phe Asn Val Gln Gly Thr Gln Pro 
            260                 265                 270         


Lys Met Val Met Glu Tyr Trp Thr Gly Trp Phe Asp Ser Trp Gly Gly 
        275                 280                 285             


Pro His Asn Ile Leu Asp Ser Ser Glu Val Leu Lys Thr Val Ser Ala 
    290                 295                 300                 


Ile Val Asp Ala Gly Ser Ser Ile Asn Leu Tyr Met Phe His Gly Gly 
305                 310                 315                 320 


Thr Asn Phe Gly Phe Met Asn Gly Ala Met His Phe His Asp Tyr Lys 
                325                 330                 335     


Ser Asp Val Thr Ser Tyr Asp Tyr Asp Ala Val Leu Thr Glu Ala Gly 
            340                 345                 350         


Asp Tyr Thr Ala Lys Tyr Met Lys Leu Arg Asp Phe Phe Gly Ser Ile 
        355                 360                 365             


Ser Gly Ile Pro Leu Pro Pro Pro Pro Asp Leu Leu Pro Lys Met Pro 
    370                 375                 380                 


Tyr Glu Pro Leu Thr Pro Val Leu Tyr Leu Ser Leu Trp Asp Ala Leu 
385                 390                 395                 400 


Lys Tyr Leu Gly Glu Pro Ile Lys Ser Glu Lys Pro Ile Asn Met Glu 
                405                 410                 415     


Asn Leu Pro Val Asn Gly Gly Asn Gly Gln Ser Phe Gly Tyr Ile Leu 
            420                 425                 430         


Tyr Glu Thr Ser Ile Thr Ser Ser Gly Ile Leu Ser Gly His Val His 
        435                 440                 445             


Asp Arg Gly Gln Val Phe Val Asn Thr Val Ser Ile Gly Phe Leu Asp 
    450                 455                 460                 


Tyr Lys Thr Thr Lys Ile Ala Val Pro Leu Ile Gln Gly Tyr Thr Val 
465                 470                 475                 480 


Leu Arg Ile Leu Val Glu Asn Arg Gly Arg Val Asn Tyr Gly Glu Asn 
                485                 490                 495     


Ile Asp Asp Gln Arg Lys Gly Leu Ile Gly Asn Leu Tyr Leu Asn Asp 
            500                 505                 510         


Ser Pro Leu Lys Asn Phe Arg Ile Tyr Ser Leu Asp Met Lys Lys Ser 
        515                 520                 525             


Phe Phe Gln Arg Phe Gly Leu Asp Lys Trp Ser Ser Leu Pro Glu Thr 
    530                 535                 540                 


Pro Thr Leu Pro Ala Phe Phe Leu Gly Ser Leu Ser Ile Ser Ser Thr 
545                 550                 555                 560 


Pro Cys Asp Thr Phe Leu Lys Leu Glu Gly Trp Glu Lys Gly Val Val 
                565                 570                 575     


Phe Ile Asn Gly Gln Asn Leu Gly Arg Tyr Trp Asn Ile Gly Pro Gln 
            580                 585                 590         


Lys Thr Leu Tyr Leu Pro Gly Pro Trp Leu Ser Ser Gly Ile Asn Gln 
        595                 600                 605             


Val Ile Val Phe Glu Glu Thr Met Ala Gly Pro Ala Leu Gln Phe Thr 
    610                 615                 620                 


Glu Thr Pro His Leu Gly Arg Asn Gln Tyr Ile Lys 
625                 630                 635     


<210>  5733
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  5733

Met Ala Ala Ala Ala Gly Arg Ser Leu Leu Leu Leu Leu Ser Ser Arg 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Ala Gly Gly Cys Gly Ala Leu Thr Ala Gly 
            20                  25                  30          


Cys Phe Pro Gly Leu Gly Val Ser Arg His Arg Gln Gln Gln His His 
        35                  40                  45              


Arg Thr Val His Gln Arg Ile Ala Ser Trp Gln Asn Leu Gly Ala Val 
    50                  55                  60                  


Tyr Cys Ser Thr Val Val Pro Ser Asp Asp Val Thr Val Val Tyr Gln 
65                  70                  75                  80  


Asn Gly Leu Pro Val Ile Ser Val Arg Leu Pro Ser Arg Arg Glu Arg 
                85                  90                  95      


Cys Gln Phe Thr Leu Lys Pro Ile Ser Asp Ser Val Gly Val Phe Leu 
            100                 105                 110         


Arg Gln Leu Gln Glu Glu Asp Arg Gly Ile Asp Arg Val Ala Ile Tyr 
        115                 120                 125             


Ser Pro Asp Gly Val Arg Val Ala Ala Ser Thr Gly Ile Asp Leu Leu 
    130                 135                 140                 


Leu Leu Asp Asp Phe Lys Leu Val Ile Asn Asp Leu Thr Tyr His Val 
145                 150                 155                 160 


Arg Pro Pro Lys Arg Asp Leu Leu Ser His Glu Asn Ala Ala Thr Leu 
                165                 170                 175     


Asn Asp Val Lys Thr Leu Val Gln Gln Leu Tyr Thr Thr Leu Cys Ile 
            180                 185                 190         


Glu Gln His Gln Leu Asn Lys Glu Arg Glu Leu Ile Glu Arg Leu Glu 
        195                 200                 205             


Asp Leu Lys Glu Gln Leu Ala Pro Leu Glu Lys Val Arg Ile Glu Ile 
    210                 215                 220                 


Ser Arg Lys Ala Glu Lys Arg Thr Thr Leu Val Leu Trp Gly Gly Leu 
225                 230                 235                 240 


Ala Tyr Met Ala Thr Gln Phe Gly Ile Leu Ala Arg Leu Thr Trp Trp 
                245                 250                 255     


Glu Tyr Ser Trp Asp Ile Met Glu Pro Val Thr Tyr Phe Ile Thr Tyr 
            260                 265                 270         


Gly Ser Ala Met Ala Met Tyr Ala Tyr Phe Val Met Thr Arg Gln Glu 
        275                 280                 285             


Tyr Val Tyr Pro Glu Ala Arg Asp Arg Gln Tyr Leu Leu Phe Phe His 
    290                 295                 300                 


Lys Gly Ala Lys Lys Ser Arg Phe Asp Leu Glu Lys Tyr Asn Gln Leu 
305                 310                 315                 320 


Lys Asp Ala Ile Ala Gln Ala Glu Met Asp Leu Lys Arg Leu Arg Asp 
                325                 330                 335     


Pro Leu Gln Val His Leu Pro Leu Arg Gln Ile Gly Glu Lys Asp 
            340                 345                 350     


<210>  5734
<211>  821
<212>  PRT
<213>  Homo sapiens

<400>  5734

Met Ala Gly Ser Asp Ala Glu Trp Val Thr Ile Ala Asn Asn Leu Leu 
1               5                   10                  15      


Phe Lys Cys His Ile His Leu Arg Ile His Glu Leu Gln Asp Cys Asp 
            20                  25                  30          


Ala Asn Val Phe Ile Ala Leu Tyr Gln Ser Ile Leu Gly Glu Lys Val 
        35                  40                  45              


Pro Asp Leu Ile Val Ile Pro Arg Ser Gln Glu Asp Asp Ala His Asn 
    50                  55                  60                  


Val Gln Ala Val Ile Asp Ser Leu Ala Leu Asp Tyr Leu Gln Val Ser 
65                  70                  75                  80  


Leu Ser His Ile Thr Gly Glu Asn Ile Val Lys Gly Asp Lys Glu Ser 
                85                  90                  95      


Ile Lys Asn Leu Leu Glu Ile Phe Asp Gly Leu Leu Glu Tyr Leu Thr 
            100                 105                 110         


Glu Arg Ile Ser Glu Thr Ser His Glu Lys Ser Glu Thr Glu Gln Tyr 
        115                 120                 125             


Phe Lys Glu Ser Asp Arg Gly Glu Arg Leu Glu Glu Pro Glu Ser Thr 
    130                 135                 140                 


Lys Glu Ser Lys Ser Ser Trp Lys Arg Val Ser Phe Gly Arg Cys Ser 
145                 150                 155                 160 


Leu Ser Ser Glu Met Leu Gly Pro Ser Trp Asp Gly Asp Glu Ala Glu 
                165                 170                 175     


Ser Thr Gly Glu Ile Ile Arg Leu Gly Asp Thr Ala His Thr Phe Ser 
            180                 185                 190         


Leu Arg Ser Asn Gly Ala Gln Cys Pro Asn Glu Met Leu Ser Lys Lys 
        195                 200                 205             


Ala Leu Ala Ser Pro Ser Ser Lys Ser His Glu Asp Met Leu Tyr Pro 
    210                 215                 220                 


Pro Ser Val Leu Ser Lys Ser Arg Thr Ser Phe Val Glu Asp Thr Glu 
225                 230                 235                 240 


Thr Leu Ser Val Ser Gly Ile Pro Asn Ala Arg Lys Leu Gly Glu Pro 
                245                 250                 255     


Ile Arg Ala Ala Ile Pro Leu His Pro Pro Tyr His Pro Ser Glu Pro 
            260                 265                 270         


Arg Ala Pro Cys Pro Ile Gly Lys Glu Tyr Leu His Ser Ser His Cys 
        275                 280                 285             


Ser Pro Ala Val Asn Ser Thr Gly Glu His Thr Glu Phe Ser Gly Asp 
    290                 295                 300                 


Leu Asp Asp Gly Leu Phe Leu Ile Ser Lys Leu Pro Lys Gly Ser Lys 
305                 310                 315                 320 


Trp Glu Val Tyr Pro Ala Gln Val Gln Gly Pro Arg Thr Arg Lys Pro 
                325                 330                 335     


Pro Lys Gly Lys Arg Asn Glu Asn Arg Ala Thr Ala Ser Ser Cys Asn 
            340                 345                 350         


Ser Pro Phe Pro Gln Arg Pro Arg Lys Arg Leu Thr Glu Gln Glu Leu 
        355                 360                 365             


His Asp Val Ser Glu Lys Leu Ser Gln Arg Leu Ser Glu Leu Asp Trp 
    370                 375                 380                 


Met Leu Lys Ser Ala Leu Gly Asp Arg Ile Lys Glu Lys Thr Asp His 
385                 390                 395                 400 


Lys Glu Glu Asn Thr Gly Asn Glu Glu Val Glu Asp Gly Thr Glu Glu 
                405                 410                 415     


Thr Leu Ser Gln His Ser Asp Gly Ile Val Glu Tyr Gly Pro Lys Lys 
            420                 425                 430         


Ser Arg Pro Gly Leu Ser Met Arg Arg Lys Pro Pro Tyr Arg Ser His 
        435                 440                 445             


Ser Leu Ser Pro Ser Pro Val Asn Lys His Lys Gln Phe His Leu Glu 
    450                 455                 460                 


Arg Lys Arg Gln Arg Lys Pro Arg Glu Thr Asp Val Arg Gln Phe Gln 
465                 470                 475                 480 


Ala Gln Ala Phe Thr Glu Ala Phe Glu Arg Glu Leu Arg Arg His Lys 
                485                 490                 495     


Val Gln Glu Asn Ile Gly Pro Leu Arg Ile His Glu Lys Glu Glu Glu 
            500                 505                 510         


Thr Glu Lys Ile Tyr Arg Gly Glu Ala Val Arg Lys Gly Thr Pro Glu 
        515                 520                 525             


Cys Ser Gln Pro Trp Lys Ile Tyr Ser Arg Lys Thr Thr Thr Gln Ser 
    530                 535                 540                 


Leu Arg Gly Gly Leu Pro Lys Pro Asn Lys Ala Val Pro Met Lys Val 
545                 550                 555                 560 


Ser Glu His Ser Leu Leu Pro Leu Met Leu Glu Gln Phe Pro Phe Leu 
                565                 570                 575     


Tyr Val Ser Gly Pro Thr Leu Ser Lys Met Trp Lys Gln Gln Ile Ala 
            580                 585                 590         


Gln Val Glu Gln Leu Lys Lys Glu Ala Cys Arg Glu Asn Arg Ser Lys 
        595                 600                 605             


Lys Lys Leu Gln Asp Glu Ile Glu Glu Ala Leu Arg Arg His Asp Leu 
    610                 615                 620                 


Leu Thr Thr Leu Val Lys Lys Glu Tyr Glu His Asn Lys Arg Leu Gln 
625                 630                 635                 640 


Asp Phe Lys Asp Cys Ile Arg Arg Gln Arg Leu Thr Gln Ser Lys Ile 
                645                 650                 655     


Lys Glu Asn Arg Gln Gln Ile Val Arg Ala Arg Lys Tyr Tyr Asp Asp 
            660                 665                 670         


Tyr Arg Val Gln Leu Cys Ala Lys Met Met Arg Met Arg Thr Arg Glu 
        675                 680                 685             


Glu Met Ile Phe Lys Lys Leu Phe Glu Glu Gly Leu Asn Ile Gln Lys 
    690                 695                 700                 


Gln Arg Leu Arg Asp Leu Arg Asn Tyr Ala Lys Glu Lys Arg Asp Glu 
705                 710                 715                 720 


Gln Arg Arg Arg His Gln Asp Glu Leu Asp Ser Met Glu Asn Tyr Tyr 
                725                 730                 735     


Lys Asp Gln Phe Ser Leu Leu Ala Glu Ala Ile Ser Gln Glu His Gln 
            740                 745                 750         


Glu Leu Lys Ala Arg Glu Lys Ser Gln Ala Gln Thr Leu His Lys Val 
        755                 760                 765             


Lys Arg Glu Leu Arg Ser Lys Met Glu Lys Glu Ile Gln Gln Leu Gln 
    770                 775                 780                 


Asp Met Ile Thr Gln Asn Asp Asp Asp Val Phe Phe Arg Glu Leu Glu 
785                 790                 795                 800 


Ala Glu Arg Phe Arg Ser Arg Leu Gln Leu Ala Ser Phe Gln Tyr Ser 
                805                 810                 815     


Lys Ser Pro Ser Leu 
            820     


<210>  5735
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  5735

Met Arg Arg Arg Arg Ala Ala Val Ala Ala Gly Phe Cys Ala Ser Phe 
1               5                   10                  15      


Leu Leu Gly Ser Val Leu Asn Val Leu Phe Ala Pro Gly Ser Glu Pro 
            20                  25                  30          


Pro Arg Pro Gly Gln Ser Pro Glu Pro Ser Pro Ala Pro Gly Pro Gly 
        35                  40                  45              


Arg Arg Gly Gly Arg Gly Glu Leu Ala Arg Gln Ile Arg Ala Arg Tyr 
    50                  55                  60                  


Glu Glu Val Gln Arg Tyr Ser Arg Gly Gly Pro Gly Pro Gly Ala Gly 
65                  70                  75                  80  


Arg Pro Glu Arg Arg Arg Leu Met Asp Leu Ala Pro Gly Gly Pro Gly 
                85                  90                  95      


Leu Pro Arg Pro Arg Pro Pro Trp Ala Arg Pro Leu Ser Asp Gly Ala 
            100                 105                 110         


Pro Gly Trp Pro Pro Ala Pro Gly Pro Gly Ser Pro Gly Pro Gly Pro 
        115                 120                 125             


Arg Leu Gly Cys Ala Ala Leu Arg Asn Val Ser Gly Ala Gln Tyr Met 
    130                 135                 140                 


Gly Ser Gly Tyr Thr Lys Ala Val Tyr Arg Val Arg Leu Pro Gly Gly 
145                 150                 155                 160 


Ala Ala Val Ala Leu Lys Ala Val Asp Phe Ser Gly His Asp Leu Gly 
                165                 170                 175     


Ser Cys Val Arg Glu Phe Gly Val Arg Arg Gly Cys Tyr Arg Leu Ala 
            180                 185                 190         


Ala His Lys Leu Leu Lys Glu Met Val Leu Leu Glu Arg Leu Arg His 
        195                 200                 205             


Pro Asn Val Leu Gln Leu Tyr Gly Tyr Cys Tyr Gln Asp Ser Glu Asp 
    210                 215                 220                 


Ile Pro Asp Thr Leu Thr Thr Ile Thr Glu Leu Gly Ala Pro Val Glu 
225                 230                 235                 240 


Met Ile Gln Leu Leu Gln Thr Ser Trp Glu Asp Arg Phe Arg Ile Cys 
                245                 250                 255     


Leu Ser Leu Gly Arg Leu Leu His His Leu Ala His Ser Pro Leu Gly 
            260                 265                 270         


Ser Val Thr Leu Leu Asp Phe Arg Pro Arg Gln Phe Val Leu Val Asp 
        275                 280                 285             


Gly Glu Leu Lys Val Thr Asp Leu Asp Asp Ala Arg Val Glu Glu Thr 
    290                 295                 300                 


Pro Cys Ala Gly Ser Thr Asp Cys Ile Leu Glu Phe Pro Ala Arg Asn 
305                 310                 315                 320 


Phe Thr Leu Pro Cys Ser Ala Gln Gly Trp Cys Glu Gly Met Asn Glu 
                325                 330                 335     


Lys Arg Asn Leu Tyr Asn Ala Tyr Arg Phe Phe Phe Thr Tyr Leu Leu 
            340                 345                 350         


Pro His Ser Ala Pro Pro Ser Leu Arg Pro Leu Leu Asp Ser Ile Val 
        355                 360                 365             


Asn Ala Thr Gly Glu Leu Ala Trp Gly Val Asp Glu Thr Leu Ala Gln 
    370                 375                 380                 


Leu Glu Lys Val Leu His Leu Tyr Arg Ser Gly Gln Tyr Leu Gln Asn 
385                 390                 395                 400 


Ser Thr Ala Ser Ser Ser Thr Glu Tyr Gln Cys Ile Pro Asp Ser Thr 
                405                 410                 415     


Ile Pro Gln Glu Asp Tyr Arg Cys Trp Pro Ser Tyr His His Gly Ser 
            420                 425                 430         


Cys Leu Leu Ser Val Phe Asn Leu Ala Glu Ala Val Asp Val Cys Glu 
        435                 440                 445             


Ser His Ala Gln Cys Arg Ala Phe Val Val Thr Asn Gln Thr Thr Trp 
    450                 455                 460                 


Thr Gly Arg Gln Leu Val Phe Phe Lys Thr Gly Trp Ser Gln Val Val 
465                 470                 475                 480 


Pro Asp Pro Asn Lys Thr Thr Tyr Val Lys Ala Ser Gly 
                485                 490             


<210>  5736
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  5736

Met Pro Val Thr Val Thr Arg Thr Thr Ile Thr Thr Thr Thr Thr Ser 
1               5                   10                  15      


Ser Ser Gly Leu Gly Ser Pro Met Ile Val Gly Ser Pro Arg Ala Leu 
            20                  25                  30          


Thr Gln Pro Leu Gly Leu Leu Arg Leu Leu Gln Leu Val Ser Thr Cys 
        35                  40                  45              


Val Ala Phe Ser Leu Val Ala Ser Val Gly Ala Trp Thr Gly Ser Met 
    50                  55                  60                  


Gly Asn Trp Ser Met Phe Thr Trp Cys Phe Cys Phe Ser Val Thr Leu 
65                  70                  75                  80  


Ile Ile Leu Ile Val Glu Leu Cys Gly Leu Gln Ala Arg Phe Pro Leu 
                85                  90                  95      


Ser Trp Arg Asn Phe Pro Ile Thr Phe Ala Cys Tyr Ala Ala Leu Phe 
            100                 105                 110         


Cys Leu Ser Ala Ser Ile Ile Tyr Pro Thr Thr Tyr Val Gln Phe Leu 
        115                 120                 125             


Ser His Gly Arg Ser Arg Asp His Ala Ile Ala Ala Thr Phe Phe Ser 
    130                 135                 140                 


Cys Ile Ala Cys Val Ala Tyr Ala Thr Glu Val Ala Trp Thr Arg Ala 
145                 150                 155                 160 


Arg Pro Gly Glu Ile Thr Gly Tyr Met Ala Thr Val Pro Gly Leu Leu 
                165                 170                 175     


Lys Val Leu Glu Thr Phe Val Ala Cys Ile Ile Phe Ala Phe Ile Ser 
            180                 185                 190         


Asp Pro Asn Leu Tyr Gln His Gln Pro Ala Leu Glu Trp Cys Val Ala 
        195                 200                 205             


Val Tyr Ala Ile Cys Phe Ile Leu Ala Ala Ile Ala Ile Leu Leu Asn 
    210                 215                 220                 


Leu Gly Glu Cys Thr Asn Val Leu Pro Ile Pro Phe Pro Ser Phe Leu 
225                 230                 235                 240 


Ser Gly Leu Ala Leu Leu Ser Val Leu Leu Tyr Ala Thr Ala Leu Val 
                245                 250                 255     


Leu Trp Pro Leu Tyr Gln Phe Asp Glu Lys Tyr Gly Gly Gln Pro Arg 
            260                 265                 270         


Arg Ser Arg Asp Val Ser Cys Ser Arg Ser His Ala Tyr Tyr Val Cys 
        275                 280                 285             


Ala Trp Asp Arg Arg Leu Ala Val Ala Ile Leu Thr Ala Ile Asn Leu 
    290                 295                 300                 


Leu Ala Tyr Val Ala Asp Leu Val His Ser Ala His Leu Val Phe Val 
305                 310                 315                 320 


Lys Val 
        


<210>  5737
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  5737

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu Met Ile Ile Ala 
305                 310                 315                 320 


Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val Ala Phe Leu Leu 
                325                 330                 335     


Arg Gly Lys Leu Met Glu Thr Tyr Cys Ser Gln Lys His Thr Arg Leu 
            340                 345                 350         


Asp Tyr Ile Gly Asp Ser Lys Asn Val Leu Asn Asp Val Gln His Gly 
        355                 360                 365             


Arg Glu Asp Glu Asp Gly Leu Phe Thr Leu 
    370                 375             


<210>  5738
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  5738

Met Asp Ser Pro Glu Val Thr Phe Thr Leu Ala Tyr Leu Val Phe Ala 
1               5                   10                  15      


Val Cys Phe Val Phe Thr Pro Asn Glu Phe His Ala Ala Gly Leu Thr 
            20                  25                  30          


Val Gln Asn Leu Leu Ser Gly Trp Leu Gly Ser Glu Asp Ala Ala Phe 
        35                  40                  45              


Val Pro Phe His Leu Arg Arg Thr Ala Ala Thr Leu Leu Cys His Ser 
    50                  55                  60                  


Leu Leu Pro Leu Gly Tyr Tyr Val Gly Met Cys Leu Ala Ala Ser Glu 
65                  70                  75                  80  


Lys Arg Leu His Ala Leu Ser Gln Ala Pro Glu Ala Trp Arg Leu Phe 
                85                  90                  95      


Leu Leu Leu Ala Val Thr Leu Pro Ser Ile Ala Cys Ile Leu Ile Tyr 
            100                 105                 110         


Tyr Trp Ser Arg Asp Arg Trp Ala Cys His Pro Leu Ala Arg Thr Leu 
        115                 120                 125             


Ala Leu Tyr Ala Leu Pro Gln Ser Gly Trp Gln Ala Val Ala Ser Ser 
    130                 135                 140                 


Val Asn Thr Glu Phe Arg Arg Ile Asp Lys Phe Ala Thr Gly Ala Pro 
145                 150                 155                 160 


Gly Ala Arg Val Ile Val Thr Asp Thr Trp Val Met Lys Val Thr Thr 
                165                 170                 175     


Tyr Arg Val His Val Ala Gln Gln Gln Asp Val His Leu Thr Val Thr 
            180                 185                 190         


Glu Ser Arg Gln His Glu Leu Ser Pro Asp Ser Asn Leu Pro Val Gln 
        195                 200                 205             


Leu Leu Thr Ile Arg Val Ala Ser Thr Asn Pro Ala Val Gln Ala Phe 
    210                 215                 220                 


Asp Ile Trp Ser Trp Arg Pro Ala 
225                 230         


<210>  5739
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  5739

Met Glu Ser Thr Leu Gly Ala Gly Ile Val Ile Ala Glu Ala Leu Gln 
1               5                   10                  15      


Asn Gln Leu Ala Trp Leu Glu Asn Val Trp Leu Trp Ile Thr Phe Leu 
            20                  25                  30          


Gly Asp Pro Lys Ile Leu Phe Leu Phe Tyr Phe Pro Ala Ala Tyr Tyr 
        35                  40                  45              


Ala Ser Arg Arg Val Gly Ile Ala Val Leu Trp Ile Ser Leu Ile Thr 
    50                  55                  60                  


Glu Trp Leu Asn Leu Ile Phe Lys Trp Phe Leu Phe Gly Asp Arg Pro 
65                  70                  75                  80  


Phe Trp Trp Val His Glu Ser Gly Tyr Tyr Ser Gln Ala Pro Ala Gln 
                85                  90                  95      


Val His Gln Phe Pro Ser Ser Cys Glu Thr Gly Pro Gly Ser Pro Ser 
            100                 105                 110         


Gly His Cys Met Ile Thr Gly Ala Ala Leu Trp Pro Ile Met Thr Ala 
        115                 120                 125             


Leu Ser Ser Gln Val Ala Thr Arg Ala Arg Ser Arg Trp Val Arg Val 
    130                 135                 140                 


Met Pro Ser Leu Ala Tyr Cys Thr Phe Leu Leu Ala Val Gly Leu Ser 
145                 150                 155                 160 


Arg Ile Phe Ile Leu Ala His Phe Pro His Gln Val Leu Ala Gly Leu 
                165                 170                 175     


Ile Thr Gly Ala Val Leu Gly Trp Leu Met Thr Pro Arg Val Pro Met 
            180                 185                 190         


Glu Arg Glu Leu Ser Phe Tyr Gly Leu Thr Ala Leu Ala Leu Met Leu 
        195                 200                 205             


Gly Thr Ser Leu Ile Tyr Trp Thr Leu Phe Thr Leu Gly Leu Asp Leu 
    210                 215                 220                 


Ser Trp Ser Ile Ser Leu Ala Phe Lys Trp Cys Glu Arg Pro Glu Trp 
225                 230                 235                 240 


Ile His Val Asp Ser Arg Pro Phe Ala Ser Leu Ser Arg Asp Ser Gly 
                245                 250                 255     


Ala Ala Leu Gly Leu Gly Ile Ala Leu His Ser Pro Cys Tyr Ala Gln 
            260                 265                 270         


Val Arg Arg Ala Gln Leu Gly Asn Gly Gln Lys Ile Ala Cys Leu Val 
        275                 280                 285             


Leu Ala Met Gly Leu Leu Gly Pro Leu Asp Trp Leu Gly His Pro Pro 
    290                 295                 300                 


Gln Ile Ser Leu Phe Tyr Ile Phe Asn Phe Leu Lys Tyr Thr Leu Trp 
305                 310                 315                 320 


Pro Cys Leu Val Leu Ala Leu Val Pro Trp Ala Val His Met Phe Ser 
                325                 330                 335     


Ala Gln Glu Ala Pro Pro Ile His Ser Ser 
            340                 345     


<210>  5740
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  5740

Met Glu Glu Pro Thr Ala Val Glu Gly Gln Val Gln Leu Pro Ser Pro 
1               5                   10                  15      


His Gln Gly Ser Leu Arg Lys Ala Val Ala Ala Ala Leu Ala Leu Asp 
            20                  25                  30          


Gly Glu Ser Thr Met Gly His Arg Lys Lys Lys Arg Lys Glu Ser Arg 
        35                  40                  45              


Pro Glu Ser Ile Ile Ile Tyr Arg Ser Asp Asn Glu Lys Thr Asp Glu 
    50                  55                  60                  


Glu Pro Gly Glu Ser Glu Gly Gly Asp Gln Pro Lys Glu Glu Glu Gly 
65                  70                  75                  80  


Asp Asp Phe Leu Asp Tyr Pro Val Asp Asp Asp Met Trp Asn Leu Pro 
                85                  90                  95      


Leu Asp Ser Arg Tyr Val Thr Leu Thr Gly Thr Ile Thr Arg Gly Lys 
            100                 105                 110         


Lys Lys Gly Gln Met Val Asp Ile His Val Thr Leu Thr Glu Lys Glu 
        115                 120                 125             


Leu Gln Glu Leu Thr Lys Pro Lys Glu Ser Ser Arg Glu Thr Thr Pro 
    130                 135                 140                 


Glu Gly Arg Met Ala Cys Gln Met Gly Ala Asp Arg Gly Pro His Val 
145                 150                 155                 160 


Val Leu Trp Thr Leu Ile Cys Leu Pro Val Val Phe Ile Leu Ser Phe 
                165                 170                 175     


Val Val Ser Phe Tyr Tyr Gly Thr Ile Thr Trp Tyr Asn Ile Phe Leu 
            180                 185                 190         


Val Tyr Asn Glu Glu Arg Thr Phe Trp His Lys Ile Ser Tyr Cys Pro 
        195                 200                 205             


Cys Leu Val Leu Phe Tyr Pro Val Leu Ile Met Ala Met Ala Ser Ser 
    210                 215                 220                 


Leu Gly Leu Tyr Ala Ala Val Val Gln Leu Ser Trp Ser Trp Glu Ala 
225                 230                 235                 240 


Trp Trp Gln Ala Ala Arg Asp Met Glu Lys Gly Phe Cys Gly Trp Leu 
                245                 250                 255     


Cys Ser Lys Leu Gly Leu Glu Asp Cys Ser Pro Tyr Ser Ile Val Glu 
            260                 265                 270         


Leu Leu Glu Ser Asp Asn Ile Ser Ser Thr Leu Ser Asn Lys Asp Pro 
        275                 280                 285             


Ile Gln Glu Val Glu Thr Ser Thr Val 
    290                 295         


<210>  5741
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  5741

Met Ala Arg Gly Pro Gly Pro Leu Gly Arg Pro Arg Pro Asp Thr Val 
1               5                   10                  15      


Ala Met Pro Lys Arg Gly Lys Arg Leu Lys Phe Arg Ala His Asp Ala 
            20                  25                  30          


Cys Ser Gly Arg Val Thr Val Ala Asp Tyr Ala Asn Ser Asp Pro Ala 
        35                  40                  45              


Val Val Arg Ser Gly Arg Val Lys Lys Ala Val Ala Asn Ala Val Gln 
    50                  55                  60                  


Gln Glu Val Lys Ser Leu Cys Gly Leu Glu Ala Ser Gln Val Pro Ala 
65                  70                  75                  80  


Glu Glu Ala Leu Ser Gly Ala Gly Glu Pro Cys Asp Ile Ile Asp Ser 
                85                  90                  95      


Ser Asp Glu Met Asp Ala Gln Glu Glu Ser Ile His Glu Arg Thr Val 
            100                 105                 110         


Ser Arg Lys Lys Lys Ser Lys Arg His Lys Glu Glu Leu Asp Gly Ala 
        115                 120                 125             


Gly Gly Glu Glu Tyr Pro Met Asp Ile Trp Leu Leu Leu Ala Ser Tyr 
    130                 135                 140                 


Ile Arg Pro Glu Asp Ile Val Asn Phe Ser Leu Ile Cys Lys Asn Ala 
145                 150                 155                 160 


Trp Thr Val Thr Cys Thr Ala Ala Phe Trp Thr Arg Leu Tyr Arg Arg 
                165                 170                 175     


His Tyr Thr Leu Asp Ala Ser Leu Pro Leu Arg Leu Arg Pro Glu Ser 
            180                 185                 190         


Met Glu Lys Leu Arg Cys Leu Arg Ala Cys Val Ile Arg Ser Leu Tyr 
        195                 200                 205             


His Met Tyr Glu Pro Phe Ala Ala Arg Ile Ser Lys Asn Pro Ala Ile 
    210                 215                 220                 


Pro Glu Ser Thr Pro Ser Thr Leu Lys Asn Ser Lys Cys Leu Leu Phe 
225                 230                 235                 240 


Trp Cys Arg Lys Ile Val Gly Asn Arg Gln Glu Pro Met Trp Glu Phe 
                245                 250                 255     


Asn Phe Lys Phe Lys Lys Gln Ser Pro Arg Leu Lys Ser Lys Cys Thr 
            260                 265                 270         


Gly Gly Leu Gln Pro Pro Val Gln Tyr Glu Asp Val His Thr Asn Pro 
        275                 280                 285             


Asp Gln Asp Cys Cys Leu Leu Gln Val Thr Thr Leu Asn Phe Ile Phe 
    290                 295                 300                 


Ile Pro Ile Val Met Gly Met Ile Phe Thr Leu Phe Thr Ile Asn Val 
305                 310                 315                 320 


Ser Thr Asp Met Arg His His Arg Val Arg Leu Val Phe Gln Asp Ser 
                325                 330                 335     


Pro Val His Gly Gly Arg Lys Leu Arg Ser Glu Gln Gly Val Gln Val 
            340                 345                 350         


Ile Leu Asp Pro Val His Ser Val Arg Leu Phe Asp Trp Trp His Pro 
        355                 360                 365             


Gln Tyr Pro Phe Ser Leu Arg Ala 
    370                 375     


<210>  5742
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  5742

Met Asp Gly Leu Arg Gln Arg Val Glu His Phe Leu Glu Gln Arg Asn 
1               5                   10                  15      


Leu Val Thr Glu Val Leu Gly Ala Leu Glu Ala Lys Thr Gly Val Glu 
            20                  25                  30          


Lys Arg Tyr Leu Ala Ala Gly Ala Val Thr Leu Leu Ser Leu Tyr Leu 
        35                  40                  45              


Leu Phe Gly Tyr Gly Ala Ser Leu Leu Cys Asn Leu Ile Gly Phe Val 
    50                  55                  60                  


Tyr Pro Ala Tyr Ala Ser Ile Lys Ala Ile Glu Ser Pro Ser Lys Asp 
65                  70                  75                  80  


Asp Asp Thr Val Trp Leu Thr Tyr Trp Val Val Tyr Ala Leu Phe Gly 
                85                  90                  95      


Leu Ala Glu Phe Phe Ser Asp Leu Leu Leu Ser Trp Phe Pro Phe Tyr 
            100                 105                 110         


Tyr Val Gly Lys Cys Ala Phe Leu Leu Phe Cys Met Ala Pro Arg Pro 
        115                 120                 125             


Trp Asn Gly Ala Leu Met Leu Tyr Gln Arg Val Val Arg Pro Leu Phe 
    130                 135                 140                 


Leu Arg His His Gly Ala Val Asp Arg Ile Met Asn Asp Leu Ser Gly 
145                 150                 155                 160 


Arg Ala Leu Asp Ala Ala Ala Gly Ile Thr Arg Asn Val Lys Pro Ser 
                165                 170                 175     


Gln Thr Pro Gln Pro Lys Asp Lys 
            180                 


<210>  5743
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  5743

Met Leu Lys Ser Arg Leu Arg Met Phe Leu Asn Glu Leu Lys Leu Leu 
1               5                   10                  15      


Val Leu Thr Gly Gly Gly Arg Pro Arg Ala Glu Pro Gln Pro Arg Gly 
            20                  25                  30          


Gly Arg Gly Gly Gly Cys Gly Trp Ala Pro Phe Ala Gly Cys Ser Thr 
        35                  40                  45              


Arg Asp Gly Asp Gly Asp Glu Glu Glu Tyr Tyr Gly Ser Glu Pro Arg 
    50                  55                  60                  


Ala Arg Gly Leu Ala Gly Asp Lys Glu Pro Arg Ala Gly Pro Leu Pro 
65                  70                  75                  80  


Pro Pro Ala Pro Pro Leu Pro Pro Pro Gly Ala Leu Asp Ala Leu Ser 
                85                  90                  95      


Leu Ser Ser Ser Leu Asp Ser Gly Leu Arg Thr Pro Gln Cys Arg Ile 
            100                 105                 110         


Cys Phe Gln Gly Pro Glu Gln Gly Glu Leu Leu Ser Pro Cys Arg Cys 
        115                 120                 125             


Asp Gly Ser Val Arg Cys Thr His Gln Pro Cys Leu Ile Arg Trp Ile 
    130                 135                 140                 


Ser Glu Arg Gly Ser Trp Ser Cys Glu Leu Cys Tyr Phe Lys Tyr Gln 
145                 150                 155                 160 


Val Leu Ala Ile Ser Thr Lys Asn Pro Leu Gln Trp Gln Ala Ile Ser 
                165                 170                 175     


Leu Thr Val Ile Glu Lys Val Gln Ile Ala Ala Ile Val Leu Gly Ser 
            180                 185                 190         


Leu Phe Leu Val Ala Ser Ile Ser Trp Leu Ile Trp Ser Ser Leu Ser 
        195                 200                 205             


Pro Ser Ala Lys Trp Gln Arg Gln Asp Leu Leu Phe Gln Ile Cys Tyr 
    210                 215                 220                 


Gly Met Tyr Gly Phe Met Asp Val Val Cys Ile Gly Leu Ile Ile His 
225                 230                 235                 240 


Glu Gly Ser Ser Val Tyr Arg Ile Phe Lys Arg Trp Gln Ala Val Asn 
                245                 250                 255     


Gln Gln Trp Lys Val Leu Asn Tyr Asp Lys Thr Lys Asp Ile Gly Gly 
            260                 265                 270         


Asp Ala Gly Gly Gly Thr Ala Gly Lys Ser Gly Pro Arg Asn Ser Arg 
        275                 280                 285             


Thr Gly Pro Thr Ser Gly Ala Thr Ser Arg Pro Pro Ala Ala Gln Arg 
    290                 295                 300                 


Met Arg Thr Leu Leu Pro Gln Arg Cys Gly Tyr Thr Ile Leu His Leu 
305                 310                 315                 320 


Leu Gly Gln Leu Arg Pro Pro Asp Ala Arg Ser Ser Ser His Ser Gly 
                325                 330                 335     


Arg Glu Val Val Met Arg Val Thr Thr Val 
            340                 345     


<210>  5744
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  5744

Met Ser Ala Gln Arg Leu Ile Ser Asn Arg Thr Ser Gln Gln Ser Ala 
1               5                   10                  15      


Ser Asn Ser Asp Tyr Thr Trp Glu Tyr Glu Tyr Tyr Glu Ile Gly Pro 
            20                  25                  30          


Val Ser Phe Glu Gly Leu Lys Ala His Lys Tyr Ser Ile Val Ile Gly 
        35                  40                  45              


Phe Trp Val Gly Leu Ala Val Phe Val Ile Phe Met Phe Phe Val Leu 
    50                  55                  60                  


Thr Leu Leu Thr Lys Thr Gly Ala Pro His Gln Asp Asn Ala Glu Ser 
65                  70                  75                  80  


Ser Glu Lys Arg Phe Arg Met Asn Ser Phe Val Ser Asp Phe Gly Arg 
                85                  90                  95      


Pro Leu Glu Pro Asp Lys Val Phe Ser Arg Gln Gly Asn Glu Glu Ser 
            100                 105                 110         


Arg Ser Leu Phe His Cys Tyr Ile Asn Glu Val Glu Arg Leu Asp Arg 
        115                 120                 125             


Ala Lys Ala Cys His Gln Thr Thr Ala Leu Asp Ser Asp Val Gln Leu 
    130                 135                 140                 


Gln Glu Ala Ile Arg Ser Ser Gly Gln Pro Glu Glu Glu Leu Asn Arg 
145                 150                 155                 160 


Leu Met Lys Phe Asp Ile Pro Asn Phe Val Asn Thr Asp Gln Asn Tyr 
                165                 170                 175     


Phe Gly Glu Asp Asp Leu Leu Ile Ser Glu Pro Pro Ile Val Leu Glu 
            180                 185                 190         


Thr Lys Pro Leu Ser Gln Thr Ser His Lys Asp Leu Asp 
        195                 200                 205 


<210>  5745
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  5745

Met Ser His Gly Ala Gly Leu Val Arg Thr Thr Cys Ser Ser Gly Ser 
1               5                   10                  15      


Ala Leu Gly Pro Gly Ala Gly Ala Ala Gln Pro Ser Ala Ser Pro Leu 
            20                  25                  30          


Glu Gly Leu Leu Asp Leu Ser Tyr Pro Arg Thr His Ala Ala Leu Leu 
        35                  40                  45              


Lys Val Ala Gln Met Val Thr Leu Leu Ile Ala Phe Ile Cys Val Arg 
    50                  55                  60                  


Ser Ser Leu Trp Thr Asn Tyr Ser Ala Tyr Ser Tyr Phe Glu Val Val 
65                  70                  75                  80  


Thr Ile Cys Asp Leu Ile Met Ile Leu Ala Phe Tyr Leu Val His Leu 
                85                  90                  95      


Phe Arg Phe Tyr Arg Val Leu Thr Cys Ile Ser Trp Pro Leu Ser Glu 
            100                 105                 110         


Leu Leu His Tyr Leu Ile Gly Thr Leu Leu Leu Leu Ile Ala Ser Ile 
        115                 120                 125             


Val Ala Ala Ser Lys Ser Tyr Asn Gln Ser Gly Leu Val Ala Gly Ala 
    130                 135                 140                 


Ile Phe Gly Phe Met Ala Thr Phe Leu Cys Met Ala Ser Ile Trp Leu 
145                 150                 155                 160 


Ser Tyr Lys Ile Ser Cys Val Thr Gln Ser Thr Asp Ala Ala Val 
                165                 170                 175 


<210>  5746
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  5746

Met Leu Gly Pro Gln Val Trp Ser Ser Val Arg Gln Gly Leu Ser Arg 
1               5                   10                  15      


Ser Leu Ser Arg Asn Val Gly Val Trp Ala Ser Gly Glu Gly Lys Lys 
            20                  25                  30          


Val Asp Ile Ala Gly Ile Tyr Pro Pro Val Thr Thr Pro Phe Thr Ala 
        35                  40                  45              


Thr Ala Glu Val Asp Tyr Gly Lys Leu Glu Glu Asn Leu His Lys Leu 
    50                  55                  60                  


Gly Thr Phe Pro Phe Arg Gly Phe Val Val Gln Gly Ser Asn Gly Glu 
65                  70                  75                  80  


Phe Pro Phe Leu Thr Ser Ser Glu Arg Leu Glu Val Val Ser Arg Val 
                85                  90                  95      


Arg Gln Ala Met Pro Lys Asn Arg Leu Leu Leu Ala Gly Ser Gly Cys 
            100                 105                 110         


Glu Ser Thr Gln Ala Thr Val Glu Met Thr Val Ser Met Ala Gln Val 
        115                 120                 125             


Gly Ala Asp Ala Ala Met Val Val Thr Pro Cys Tyr Tyr Arg Gly Arg 
    130                 135                 140                 


Met Ser Ser Ala Ala Leu Ile His His Tyr Thr Lys Val Ala Asp Leu 
145                 150                 155                 160 


Ser Pro Ile Pro Val Val Leu Tyr Ser Val Pro Ala Asn Thr Gly Leu 
                165                 170                 175     


Asp Leu Pro Val Asp Ala Val Val Thr Leu Ser Gln His Pro Asn Ile 
            180                 185                 190         


Val Gly Met Lys Asp Ser Gly Gly Asp Val Thr Arg Ile Gly Leu Ile 
        195                 200                 205             


Val His Lys Thr Arg Lys Gln Asp Phe Gln Val Leu Ala Gly Ser Ala 
    210                 215                 220                 


Gly Phe Leu Met Ala Ser Tyr Ala Leu Gly Ala Val Gly Gly Val Cys 
225                 230                 235                 240 


Ala Leu Ala Asn Val Leu Gly Ala Gln Val Cys Gln Leu Glu Arg Leu 
                245                 250                 255     


Cys Cys Thr Gly Gln Trp Glu Asp Ala Gln Lys Leu Gln His Arg Leu 
            260                 265                 270         


Ile Glu Pro Asn Ala Ala Val Thr Arg Arg Phe Gly Ile Pro Gly Leu 
        275                 280                 285             


Lys Lys Ile Met Asp Trp Phe Gly Tyr Tyr Gly Gly Pro Cys Arg Ala 
    290                 295                 300                 


Pro Leu Gln Glu Leu Ser Pro Ala Glu Glu Glu Ala Leu Arg Met Asp 
305                 310                 315                 320 


Phe Thr Ser Asn Gly Trp Leu 
                325         


<210>  5747
<211>  436
<212>  PRT
<213>  Homo sapiens

<400>  5747

Met Val Gly Phe Gly Ala Asn Arg Arg Ala Gly Arg Leu Pro Ser Leu 
1               5                   10                  15      


Val Leu Val Val Leu Leu Val Val Ile Val Val Leu Ala Phe Asn Tyr 
            20                  25                  30          


Trp Ser Ile Ser Ser Arg His Val Leu Leu Gln Glu Glu Val Ala Glu 
        35                  40                  45              


Leu Gln Gly Gln Val Gln Arg Thr Glu Val Ala Arg Gly Arg Leu Glu 
    50                  55                  60                  


Lys Arg Asn Ser Asp Leu Leu Leu Leu Val Asp Thr His Lys Lys Gln 
65                  70                  75                  80  


Ile Asp Gln Lys Glu Ala Asp Tyr Gly Arg Leu Ser Ser Arg Leu Gln 
                85                  90                  95      


Ala Arg Glu Gly Leu Gly Lys Arg Cys Glu Asp Asp Lys Val Lys Leu 
            100                 105                 110         


Gln Asn Asn Ile Ser Tyr Gln Met Ala Asp Ile His His Leu Lys Glu 
        115                 120                 125             


Gln Leu Ala Glu Leu Arg Gln Glu Phe Leu Arg Gln Glu Asp Gln Leu 
    130                 135                 140                 


Gln Asp Tyr Arg Lys Asn Asn Thr Tyr Leu Val Lys Arg Leu Glu Tyr 
145                 150                 155                 160 


Glu Ser Phe Gln Cys Gly Gln Gln Met Lys Glu Leu Arg Ala Gln His 
                165                 170                 175     


Glu Glu Asn Ile Lys Lys Leu Ala Asp Gln Phe Leu Glu Glu Gln Lys 
            180                 185                 190         


Gln Glu Thr Gln Lys Ile Gln Ser Asn Asp Gly Lys Glu Leu Asp Ile 
        195                 200                 205             


Asn Asn Gln Val Val Pro Lys Asn Ile Pro Lys Val Ala Glu Asn Val 
    210                 215                 220                 


Ala Asp Lys Asn Glu Glu Pro Ser Ser Asn His Ile Pro His Gly Lys 
225                 230                 235                 240 


Glu Gln Ile Lys Arg Gly Gly Asp Ala Gly Met Pro Gly Ile Glu Glu 
                245                 250                 255     


Asn Asp Leu Ala Lys Val Asp Asp Leu Pro Pro Ala Leu Arg Lys Pro 
            260                 265                 270         


Pro Ile Ser Val Ser Gln His Glu Ser His Gln Ala Ile Ser His Leu 
        275                 280                 285             


Pro Thr Gly Gln Pro Leu Ser Pro Asn Met Pro Pro Asp Ser His Ile 
    290                 295                 300                 


Asn His Asn Gly Asn Pro Gly Thr Ser Lys Gln Asn Pro Ser Ser Pro 
305                 310                 315                 320 


Leu Gln Arg Leu Ile Pro Gly Ser Asn Leu Asp Ser Glu Pro Arg Ile 
                325                 330                 335     


Gln Thr Asp Ile Leu Lys Gln Ala Thr Lys Asp Arg Val Ser Asp Phe 
            340                 345                 350         


His Lys Leu Lys Gln Ser Arg Phe Phe Asp Glu Asn Glu Ser Pro Val 
        355                 360                 365             


Asp Pro Gln His Gly Ser Lys Leu Ala Asp Tyr Asn Gly Asp Asp Gly 
    370                 375                 380                 


Asn Val Gly Glu Tyr Glu Ala Asp Lys Gln Ala Glu Leu Ala Tyr Asn 
385                 390                 395                 400 


Glu Glu Glu Asp Gly Asp Gly Gly Glu Glu Asp Val Gln Asp Asp Glu 
                405                 410                 415     


Glu Arg Glu Leu Gln Met Asp Pro Ala Asp Tyr Gly Lys Gln His Phe 
            420                 425                 430         


Asn Asp Val Leu 
        435     


<210>  5748
<211>  547
<212>  PRT
<213>  Homo sapiens

<400>  5748

Met Ser Thr Ala Ser Ser Ser Ser Ser Ser Ser Ser Ser Gln Thr Pro 
1               5                   10                  15      


His Pro Pro Ser Gln Arg Met Arg Arg Ser Ala Ala Gly Ser Pro Pro 
            20                  25                  30          


Ala Val Ala Ala Ala Gly Ser Gly Asn Gly Ala Gly Gly Gly Gly Gly 
        35                  40                  45              


Val Gly Cys Ala Pro Ala Ala Gly Ala Gly Arg Leu Leu Gln Pro Ile 
    50                  55                  60                  


Arg Ala Thr Val Pro Tyr Gln Leu Leu Arg Gly Ser Gln His Ser Pro 
65                  70                  75                  80  


Thr Arg Pro Pro Val Ala Ala Ala Ala Ala Ser Leu Gly Ser Leu Pro 
                85                  90                  95      


Gly Pro Gly Ala Ala Arg Gly Pro Ser Pro Ser Ser Pro Thr Pro Pro 
            100                 105                 110         


Ala Ala Ala Ala Pro Ala Glu Gln Ala Pro Arg Ala Lys Gly Arg Pro 
        115                 120                 125             


Arg Arg Ser Pro Glu Ser His Arg Arg Ser Ser Ser Pro Glu Arg Arg 
    130                 135                 140                 


Ser Pro Gly Ser Pro Val Cys Arg Ala Asp Lys Ala Lys Ser Gln Gln 
145                 150                 155                 160 


Val Arg Thr Ser Ser Thr Ile Arg Arg Thr Ser Ser Leu Asp Thr Ile 
                165                 170                 175     


Thr Gly Pro Tyr Leu Thr Gly Gln Trp Pro Arg Asp Pro His Val His 
            180                 185                 190         


Tyr Pro Ser Cys Met Lys Asp Lys Ala Thr Gln Thr Pro Ser Cys Trp 
        195                 200                 205             


Ala Glu Glu Gly Ala Glu Lys Arg Ser His Gln Arg Ser Ala Ser Trp 
    210                 215                 220                 


Gly Ser Ala Asp Gln Leu Lys Glu Gln Ile Ala Lys Leu Arg Gln Gln 
225                 230                 235                 240 


Leu Gln Arg Ser Lys Gln Ser Ser Arg His Ser Lys Glu Lys Asp Arg 
                245                 250                 255     


Gln Ser Pro Leu His Gly Asn His Ile Thr Ile Ser His Thr Gln Ala 
            260                 265                 270         


Thr Gly Ser Arg Ser Val Pro Met Pro Leu Ser Asn Ile Ser Val Pro 
        275                 280                 285             


Lys Ser Ser Val Ser Arg Val Pro Cys Asn Val Glu Gly Ile Ser Pro 
    290                 295                 300                 


Glu Leu Glu Lys Val Phe Ile Lys Glu Asn Asn Gly Lys Glu Glu Val 
305                 310                 315                 320 


Ser Lys Pro Leu Asp Ile Pro Asp Gly Arg Arg Ala Pro Leu Pro Ala 
                325                 330                 335     


His Tyr Arg Ser Ser Ser Thr Arg Ser Ile Asp Thr Gln Thr Pro Ser 
            340                 345                 350         


Val Gln Glu Arg Ser Ser Ser Cys Ser Ser His Ser Pro Cys Val Ser 
        355                 360                 365             


Pro Phe Cys Pro Pro Glu Ser Gln Asp Gly Ser Pro Cys Ser Thr Glu 
    370                 375                 380                 


Asp Leu Leu Tyr Asp Arg Asp Lys Asp Ser Gly Ser Ser Ser Pro Leu 
385                 390                 395                 400 


Pro Lys Tyr Ala Ser Ser Pro Lys Pro Asn Asn Ser Tyr Met Phe Lys 
                405                 410                 415     


Arg Glu Pro Pro Glu Gly Cys Glu Arg Val Lys Val Phe Glu Glu Met 
            420                 425                 430         


Ala Ser Arg Gln Pro Ile Ser Ala Pro Leu Phe Ser Cys Pro Asp Lys 
        435                 440                 445             


Asn Lys Val Asn Phe Ile Pro Thr Gly Ser Ala Phe Cys Pro Val Lys 
    450                 455                 460                 


Leu Leu Gly Pro Leu Leu Pro Ala Ser Asp Leu Met Leu Lys Asn Ser 
465                 470                 475                 480 


Pro Asn Ser Gly Gln Ser Ser Ala Leu Ala Thr Leu Thr Val Glu Gln 
                485                 490                 495     


Leu Ser Ser Arg Val Ser Phe Thr Ser Leu Ser Asp Asp Thr Ser Thr 
            500                 505                 510         


Ala Gly Ser Met Glu Ala Ser Val Gln Gln Pro Ser Gln Gln Gln Gln 
        515                 520                 525             


Leu Leu Gln Glu Leu Gln Gly Glu Asp His Ile Ser Ala Gln Asn Tyr 
    530                 535                 540                 


Val Ile Ile 
545         


<210>  5749
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  5749

Met Trp Pro Val Phe Trp Thr Val Val Arg Thr Tyr Ala Pro Tyr Val 
1               5                   10                  15      


Thr Phe Pro Val Ala Phe Val Val Gly Ala Val Gly Tyr His Leu Glu 
            20                  25                  30          


Trp Phe Ile Arg Gly Lys Asp Pro Gln Pro Val Glu Glu Glu Lys Ser 
        35                  40                  45              


Ile Ser Glu Arg Arg Glu Asp Arg Lys Leu Asp Glu Leu Leu Gly Lys 
    50                  55                  60                  


Asp His Thr Gln Val Val Ser Leu Lys Asp Lys Leu Glu Phe Ala Pro 
65                  70                  75                  80  


Lys Ala Val Leu Asn Arg Asn Arg Pro Glu Lys Asn 
                85                  90          


<210>  5750
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  5750

Met Arg Gly Lys Leu Leu Pro Leu Ala Gly Leu Tyr Leu Val Gln Gly 
1               5                   10                  15      


Leu Pro Tyr Gly Leu Gln Ser Gly Leu Leu Pro Val Leu Leu Arg Ala 
            20                  25                  30          


Gly Gly Leu Ser Leu Thr Arg Val Gly Leu Ala Lys Val Leu Tyr Ala 
        35                  40                  45              


Pro Trp Leu Leu Lys Leu Ala Trp Ala Pro Leu Val Asp Ala Gln Gly 
    50                  55                  60                  


Ser Ala Arg Ala Trp Val Thr Arg Ser Thr Ala Gly Leu Gly Leu Val 
65                  70                  75                  80  


Cys Gly Leu Leu Ala Gly Leu Pro Pro Pro Gly Ala Gly Gln Ala Gly 
                85                  90                  95      


Leu Pro Ala Ala Val Ala Gly Leu Leu Leu Leu Leu Asn Leu Gly Ala 
            100                 105                 110         


Ala Met Gln Asp Val Ala Leu Asp Ala Leu Ala Val Gln Leu Leu Glu 
        115                 120                 125             


Pro Ala Glu Leu Gly Pro Gly Asn Thr Val Gln Val Val Ala Tyr Lys 
    130                 135                 140                 


Leu Gly Ala Ala Leu Ala Gly Gly Ala Leu Leu Ala Leu Leu Pro Thr 
145                 150                 155                 160 


Phe Ser Trp Pro Gln Leu Phe Leu Leu Leu Ala Ala Thr Tyr Trp Leu 
                165                 170                 175     


Ala Ala Ala Leu Ala Trp Ala Ala Pro Ala Leu Arg Arg Leu Pro Gln 
            180                 185                 190         


Gln Pro Pro Ser Glu Gln Arg Pro His Thr Ala His Leu Leu Arg Asp 
        195                 200                 205             


Val Leu Ala Val Pro Gly Thr Val Trp Thr Ala Gly Phe Val Leu Thr 
    210                 215                 220                 


Tyr Lys Leu Gly Glu Gln Gly Ala Ser Ser Leu Phe Pro Leu Leu Leu 
225                 230                 235                 240 


Leu Asp His Gly Val Ser Ala Pro Glu Leu Gly Leu Trp Asn Gly Val 
                245                 250                 255     


Gly Ala Val Val Cys Ser Ile Ala Gly Ser Ser Leu Gly Gly Thr Leu 
            260                 265                 270         


Leu Ala Lys His Trp Lys Leu Leu Pro Leu Leu Arg Ser Val Leu Arg 
        275                 280                 285             


Phe Arg Leu Gly Gly Leu Ala Cys Gln Thr Ala Leu Val Phe His Leu 
    290                 295                 300                 


Asp Thr Leu Gly Ala Ser Met Asp Ala Gly Thr Ile Leu Arg Gly Ser 
305                 310                 315                 320 


Ala Leu Leu Ser Leu Cys Leu Gln His Phe Leu Gly Gly Leu Val Thr 
                325                 330                 335     


Thr Val Thr Phe Thr Gly Met Met Arg Cys Ser Gln Leu Ala Pro Arg 
            340                 345                 350         


Ala Leu Gln Ala Thr His Tyr Ser Leu Leu Ala Thr Leu Glu Leu Leu 
        355                 360                 365             


Gly Lys Leu Leu Leu Gly Thr Leu Ala Gly Gly Leu Ala Asp Gly Leu 
    370                 375                 380                 


Gly Pro His Pro Cys Phe Leu Leu Leu Leu Ile Leu Ser Ala Phe Pro 
385                 390                 395                 400 


Val Leu Tyr Leu Asp Leu Ala Pro Ser Thr Phe Leu 
                405                 410         


<210>  5751
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  5751

Met Asp Gly Pro Val Ala Glu His Ala Lys Gln Glu Pro Phe His Val 
1               5                   10                  15      


Val Thr Pro Leu Leu Glu Ser Trp Ala Leu Ser Gln Val Ala Gly Met 
            20                  25                  30          


Pro Val Phe Leu Lys Cys Glu Asn Val Gln Pro Ser Gly Ser Phe Lys 
        35                  40                  45              


Ile Arg Gly Ile Gly His Phe Cys Gln Glu Met Ala Lys Lys Gly Cys 
    50                  55                  60                  


Arg His Leu Val Cys Ser Ser Gly Gly Asn Ala Gly Ile Ala Ala Ala 
65                  70                  75                  80  


Tyr Ala Ala Arg Lys Leu Gly Ile Pro Ala Thr Ile Val Leu Pro Glu 
                85                  90                  95      


Ser Thr Ser Leu Gln Val Val Gln Arg Leu Gln Gly Glu Gly Ala Glu 
            100                 105                 110         


Val Gln Leu Thr Gly Lys Val Trp Asp Glu Ala Asn Leu Arg Ala Gln 
        115                 120                 125             


Glu Leu Ala Lys Arg Asp Gly Trp Glu Asn Val Pro Pro Phe Asp His 
    130                 135                 140                 


Pro Leu Ile Trp Lys Gly His Ala Ser Leu Val Gln Glu Leu Lys Ala 
145                 150                 155                 160 


Val Leu Arg Thr Pro Pro Gly Ala Leu Val Leu Ala Val Gly Gly Gly 
                165                 170                 175     


Gly Leu Leu Ala Gly Val Val Ala Gly Leu Leu Glu Val Gly Trp Gln 
            180                 185                 190         


His Val Pro Ile Ile Ala Met Glu Thr His Gly Ala His Cys Phe Asn 
        195                 200                 205             


Ala Ala Ile Thr Ala Gly Lys Leu Val Thr Leu Pro Asp Ile Thr Ser 
    210                 215                 220                 


Val Ala Lys Ser Leu Gly Ala Lys Thr Val Ala Ala Arg Ala Leu Glu 
225                 230                 235                 240 


Cys Met Gln Val Cys Lys Ile His Ser Glu Val Val Glu Asp Thr Glu 
                245                 250                 255     


Ala Val Ser Ala Val Gln Gln Leu Leu Asp Asp Glu Arg Met Leu Val 
            260                 265                 270         


Glu Pro Ala Cys Gly Ala Ala Leu Ala Ala Ile Tyr Ser Gly Leu Leu 
        275                 280                 285             


Arg Arg Leu Gln Ala Glu Gly Cys Leu Pro Pro Ser Leu Thr Ser Val 
    290                 295                 300                 


Val Val Ile Val Cys Gly Gly Asn Asn Ile Asn Ser Arg Glu Leu Gln 
305                 310                 315                 320 


Ala Leu Lys Thr His Leu Gly Gln Val 
                325                 


<210>  5752
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  5752

Met Ala Gly Gly Tyr Gly Val Met Gly Asp Asp Gly Ser Ile Asp Tyr 
1               5                   10                  15      


Thr Val His Glu Ala Trp Asn Glu Ala Thr Asn Val Tyr Leu Ile Val 
            20                  25                  30          


Ile Leu Val Ser Phe Gly Leu Phe Met Tyr Ala Lys Arg Asn Lys Arg 
        35                  40                  45              


Arg Ile Met Arg Ile Phe Ser Val Pro Pro Thr Glu Glu Thr Leu Ser 
    50                  55                  60                  


Glu Pro Asn Phe Tyr Asp Thr Ile Ser Lys Ile Arg Leu Arg Gln Gln 
65                  70                  75                  80  


Leu Glu Met Tyr Ser Ile Ser Arg Lys Tyr Asp Tyr Gln Gln Pro Gln 
                85                  90                  95      


Asn Gln Ala Asp Ser Val Gln Leu Ser Leu Glu 
            100                 105         


<210>  5753
<211>  673
<212>  PRT
<213>  Homo sapiens

<400>  5753

Met Cys Ser Arg Val Pro Leu Leu Leu Pro Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Leu Gly Pro Gly Val Gln Gly Cys Pro Ser Gly Cys Gln Cys Ser Gln 
            20                  25                  30          


Pro Gln Thr Val Phe Cys Thr Ala Arg Gln Gly Thr Thr Val Pro Arg 
        35                  40                  45              


Asp Val Pro Pro Asp Thr Val Gly Leu Tyr Val Phe Glu Asn Gly Ile 
    50                  55                  60                  


Thr Met Leu Asp Ala Gly Ser Phe Ala Gly Leu Pro Gly Leu Gln Leu 
65                  70                  75                  80  


Leu Asp Leu Ser Gln Asn Gln Ile Ala Ser Leu Pro Ser Gly Val Phe 
                85                  90                  95      


Gln Pro Leu Ala Asn Leu Ser Asn Leu Asp Leu Thr Ala Asn Arg Leu 
            100                 105                 110         


His Glu Ile Thr Asn Glu Thr Phe Arg Gly Leu Arg Arg Leu Glu Arg 
        115                 120                 125             


Leu Tyr Leu Gly Lys Asn Arg Ile Arg His Ile Gln Pro Gly Ala Phe 
    130                 135                 140                 


Asp Thr Leu Asp Arg Leu Leu Glu Leu Lys Leu Gln Asp Asn Glu Leu 
145                 150                 155                 160 


Arg Ala Leu Pro Pro Leu Arg Leu Pro Arg Leu Leu Leu Leu Asp Leu 
                165                 170                 175     


Ser His Asn Ser Leu Leu Ala Leu Glu Pro Gly Ile Leu Asp Thr Ala 
            180                 185                 190         


Asn Val Glu Ala Leu Arg Leu Ala Gly Leu Gly Leu Gln Gln Leu Asp 
        195                 200                 205             


Glu Gly Leu Phe Ser Arg Leu Arg Asn Leu His Asp Leu Asp Val Ser 
    210                 215                 220                 


Asp Asn Gln Leu Glu Arg Val Pro Pro Val Ile Arg Gly Leu Arg Gly 
225                 230                 235                 240 


Leu Thr Arg Leu Arg Leu Ala Gly Asn Thr Arg Ile Ala Gln Leu Arg 
                245                 250                 255     


Pro Glu Asp Leu Ala Gly Leu Ala Ala Leu Gln Glu Leu Asp Val Ser 
            260                 265                 270         


Asn Leu Ser Leu Gln Ala Leu Pro Gly Asp Leu Ser Gly Leu Phe Pro 
        275                 280                 285             


Arg Leu Arg Leu Leu Ala Ala Ala Arg Asn Pro Phe Asn Cys Val Cys 
    290                 295                 300                 


Pro Leu Ser Trp Phe Gly Pro Trp Val Arg Glu Ser His Val Thr Leu 
305                 310                 315                 320 


Ala Ser Pro Glu Glu Thr Arg Cys His Phe Pro Pro Lys Asn Ala Gly 
                325                 330                 335     


Arg Leu Leu Leu Glu Leu Asp Tyr Ala Asp Phe Gly Cys Pro Ala Thr 
            340                 345                 350         


Thr Thr Thr Ala Thr Val Pro Thr Thr Arg Pro Val Val Arg Glu Pro 
        355                 360                 365             


Thr Ala Leu Ser Ser Ser Leu Ala Pro Thr Trp Leu Ser Pro Thr Glu 
    370                 375                 380                 


Pro Ala Thr Glu Ala Pro Ser Pro Pro Ser Thr Ala Pro Pro Thr Val 
385                 390                 395                 400 


Gly Pro Val Pro Gln Pro Gln Asp Cys Pro Pro Ser Thr Cys Leu Asn 
                405                 410                 415     


Gly Gly Thr Cys His Leu Gly Thr Arg His His Leu Ala Cys Leu Cys 
            420                 425                 430         


Pro Glu Gly Phe Thr Gly Leu Tyr Cys Glu Ser Gln Met Gly Gln Gly 
        435                 440                 445             


Thr Arg Pro Ser Pro Thr Pro Val Thr Pro Arg Pro Pro Arg Ser Leu 
    450                 455                 460                 


Thr Leu Gly Ile Glu Pro Val Ser Pro Thr Ser Leu Arg Val Gly Leu 
465                 470                 475                 480 


Gln Arg Tyr Leu Gln Gly Ser Ser Val Gln Leu Arg Ser Leu Arg Leu 
                485                 490                 495     


Thr Tyr Arg Asn Leu Ser Gly Pro Asp Lys Arg Leu Val Thr Leu Arg 
            500                 505                 510         


Leu Pro Ala Ser Leu Ala Glu Tyr Thr Val Thr Gln Leu Arg Pro Asn 
        515                 520                 525             


Ala Thr Tyr Ser Val Cys Val Met Pro Leu Gly Pro Gly Arg Val Pro 
    530                 535                 540                 


Glu Gly Glu Glu Ala Cys Gly Glu Ala His Thr Pro Pro Ala Val His 
545                 550                 555                 560 


Ser Asn His Ala Pro Val Thr Gln Ala Arg Glu Gly Asn Leu Pro Leu 
                565                 570                 575     


Leu Ile Ala Pro Ala Leu Ala Ala Val Leu Leu Ala Ala Leu Ala Ala 
            580                 585                 590         


Val Gly Ala Ala Tyr Cys Val Arg Arg Gly Arg Ala Met Ala Ala Ala 
        595                 600                 605             


Ala Gln Asp Lys Gly Gln Val Gly Pro Gly Ala Gly Pro Leu Glu Leu 
    610                 615                 620                 


Glu Gly Val Lys Val Pro Leu Glu Pro Gly Pro Lys Ala Thr Glu Gly 
625                 630                 635                 640 


Gly Gly Glu Ala Leu Pro Ser Gly Ser Glu Cys Glu Val Pro Leu Met 
                645                 650                 655     


Gly Phe Pro Gly Pro Gly Leu Gln Ser Pro Leu His Ala Lys Pro Tyr 
            660                 665                 670         


Ile 
    


<210>  5754
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  5754

Met Trp Ser Cys Ser Trp Phe Asn Gly Thr Gly Leu Val Glu Glu Leu 
1               5                   10                  15      


Pro Ala Cys Gln Asp Leu Gln Leu Gly Leu Ser Leu Leu Ser Leu Leu 
            20                  25                  30          


Gly Leu Val Val Gly Val Pro Val Gly Leu Cys Tyr Asn Ala Leu Leu 
        35                  40                  45              


Val Leu Ala Asn Leu His Ser Lys Ala Ser Met Thr Met Pro Asp Val 
    50                  55                  60                  


Tyr Phe Val Asn Met Ala Val Ala Gly Leu Val Leu Ser Ala Leu Ala 
65                  70                  75                  80  


Pro Val His Leu Leu Gly Pro Pro Ser Ser Arg Trp Ala Leu Trp Ser 
                85                  90                  95      


Val Gly Gly Glu Val His Val Ala Leu Gln Ile Pro Phe Asn Val Ser 
            100                 105                 110         


Ser Leu Val Ala Met Tyr Ser Thr Ala Leu Leu Ser Leu Asp His Tyr 
        115                 120                 125             


Ile Glu Arg Ala Leu Pro Arg Thr Tyr Met Ala Ser Val Tyr Asn Thr 
    130                 135                 140                 


Arg His Val Cys Gly Phe Val Trp Gly Gly Ala Leu Leu Thr Ser Phe 
145                 150                 155                 160 


Ser Ser Leu Leu Phe Tyr Ile Cys Ser His Val Ser Thr Arg Ala Leu 
                165                 170                 175     


Glu Cys Ala Lys Met Gln Asn Ala Glu Ala Ala Asp Ala Thr Leu Val 
            180                 185                 190         


Phe Ile Gly Tyr Val Val Pro Ala Leu Ala Thr Leu Tyr Ala Leu Val 
        195                 200                 205             


Leu Leu Ser Arg Val Arg Arg Glu Asp Thr Pro Leu Asp Arg Asp Thr 
    210                 215                 220                 


Gly Arg Leu Glu Pro Ser Ala His Arg Leu Leu Val Ala Thr Val Cys 
225                 230                 235                 240 


Thr Gln Phe Gly Leu Trp Thr Pro His Tyr Leu Ile Leu Leu Gly His 
                245                 250                 255     


Thr Val Ile Ile Ser Arg Gly Lys Pro Val Asp Ala His Tyr Leu Gly 
            260                 265                 270         


Leu Leu His Phe Val Lys Asp Phe Ser Lys Leu Leu Ala Phe Ser Ser 
        275                 280                 285             


Ser Phe Val Thr Pro Leu Leu Tyr Arg Tyr Met Asn Gln Ser Phe Pro 
    290                 295                 300                 


Ser Lys Leu Gln Arg Leu Met Lys Lys Leu Pro Cys Gly Asp Arg His 
305                 310                 315                 320 


Cys Ser Pro Asp His Met Gly Val Gln Gln Val Leu Ala 
                325                 330             


<210>  5755
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  5755

Met Leu Ser Ala Arg Asp Arg Arg Asp Arg His Pro Glu Glu Gly Val 
1               5                   10                  15      


Val Ala Glu Leu Gln Gly Phe Ala Val Asp Lys Ala Phe Leu Thr Ser 
            20                  25                  30          


His Lys Gly Ile Leu Leu Glu Thr Glu Leu Ala Leu Thr Leu Ile Ile 
        35                  40                  45              


Phe Ile Cys Phe Thr Ala Ser Ile Ser Ala Tyr Met Ala Ala Ala Leu 
    50                  55                  60                  


Leu Glu Phe Phe Ile Thr Leu Ala Phe Leu Phe Leu Tyr Ala Thr Gln 
65                  70                  75                  80  


Tyr Tyr Gln Arg Phe Asp Arg Ile Asn Trp Pro Cys Leu Asp Phe Leu 
                85                  90                  95      


Arg Cys Val Ser Ala Ile Ile Ile Phe Leu Val Val Ser Phe Ala Ala 
            100                 105                 110         


Val Thr Ser Arg Asp Gly Ala Ala Ile Ala Ala Phe Val Phe Gly Ile 
        115                 120                 125             


Ile Leu Val Ser Ile Phe Ala Tyr Asp Ala Phe Lys Ile Tyr Arg Thr 
    130                 135                 140                 


Glu Met Ala Pro Gly Ala Ser Gln Gly Asp Gln Gln 
145                 150                 155     


<210>  5756
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  5756

Met Pro Arg Leu Leu His Pro Ala Leu Pro Leu Leu Leu Gly Ala Thr 
1               5                   10                  15      


Leu Thr Phe Arg Ala Leu Arg Arg Ala Leu Cys Arg Leu Pro Leu Pro 
            20                  25                  30          


Val His Val Arg Ala Asp Pro Leu Arg Thr Trp Arg Trp His Asn Leu 
        35                  40                  45              


Leu Val Ser Phe Ala His Ser Ile Val Ser Gly Ile Trp Ala Leu Leu 
    50                  55                  60                  


Cys Val Trp Gln Thr Pro Asp Met Leu Val Glu Ile Glu Thr Ala Trp 
65                  70                  75                  80  


Ser Leu Ser Gly Tyr Leu Leu Val Cys Phe Ser Ala Gly Tyr Phe Ile 
                85                  90                  95      


His Asp Thr Val Asp Ile Val Ala Ser Gly Gln Thr Arg Ala Ser Trp 
            100                 105                 110         


Glu Tyr Leu Val His His Val Met Ala Met Gly Ala Phe Phe Ser Gly 
        115                 120                 125             


Ile Phe Trp Ser Ser Phe Val Gly Gly Gly Val Leu Thr Leu Leu Val 
    130                 135                 140                 


Glu Val Ser Asn Ile Phe Leu Thr Ile Arg Met Met Met Lys Ile Ser 
145                 150                 155                 160 


Asn Ala Gln Asp His Leu Leu Tyr Arg Val Asn Lys Tyr Val Asn Leu 
                165                 170                 175     


Val Met Tyr Phe Leu Phe Arg Leu Ala Pro Gln Ala Tyr Leu Thr His 
            180                 185                 190         


Phe Phe Leu Arg Tyr Val Asn Gln Arg Thr Leu Gly Thr Phe Leu Leu 
        195                 200                 205             


Gly Ile Leu Leu Met Leu Asp Val Met Ile Ile Ile Tyr Phe Ser Arg 
    210                 215                 220                 


Leu Leu Arg Ser Asp Phe Cys Pro Glu His Val Pro Lys Lys Gln His 
225                 230                 235                 240 


Lys Asp Lys Phe Leu Thr Glu 
                245         


<210>  5757
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  5757

Met Thr Lys Lys Lys Arg Glu Asn Leu Gly Val Ala Leu Glu Ile Asp 
1               5                   10                  15      


Gly Leu Glu Glu Lys Leu Ser Gln Cys Arg Arg Asp Leu Glu Ala Val 
            20                  25                  30          


Asn Ser Arg Leu His Ser Arg Glu Leu Ser Pro Glu Ala Arg Arg Ser 
        35                  40                  45              


Leu Glu Lys Glu Lys Asn Ser Leu Met Asn Lys Ala Ser Asn Tyr Glu 
    50                  55                  60                  


Lys Glu Leu Lys Phe Leu Arg Gln Glu Asn Arg Lys Asn Met Leu Leu 
65                  70                  75                  80  


Ser Val Ala Ile Phe Ile Leu Leu Thr Leu Val Tyr Ala Tyr Trp Thr 
                85                  90                  95      


Met 
    


<210>  5758
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  5758

Met Ala Pro Lys Pro Gly Ala Glu Trp Ser Thr Ala Leu Ser His Leu 
1               5                   10                  15      


Val Leu Gly Val Val Ser Leu His Ala Ala Val Ser Thr Ala Glu Ala 
            20                  25                  30          


Ser Arg Gly Ala Ala Ala Gly Phe Leu Leu Gln Val Leu Ala Ala Thr 
        35                  40                  45              


Thr Thr Leu Ala Pro Gly Leu Ser Thr His Glu Asp Cys Leu Ala Gly 
    50                  55                  60                  


Ala Trp Val Ala Thr Val Ile Gly Leu Pro Leu Leu Ala Phe Asp Phe 
65                  70                  75                  80  


His Trp Cys Thr Asn Gly His Leu Met Cys Ala Gly Cys Phe Ile His 
                85                  90                  95      


Leu Leu Ala Asp Ala Arg Leu Lys Glu Glu Gln Ala Thr Cys Pro Asn 
            100                 105                 110         


Cys Arg Cys Glu Ile Ser Lys Ser Leu Cys Cys Arg Asn Leu Ala Val 
        115                 120                 125             


Glu Lys Ala Val Ser Glu Leu Pro Ser Glu Cys Gly Phe Cys Leu Arg 
    130                 135                 140                 


Gln Phe Pro Arg Ser Leu Leu Glu Arg His Gln Lys Glu Glu Cys Gln 
145                 150                 155                 160 


Asp Arg Val Thr Gln Cys Lys Tyr Lys Arg Ile Gly Cys Pro Trp His 
                165                 170                 175     


Gly Pro Phe His Glu Leu Thr Val His Glu Ala Ala Cys Ala His Pro 
            180                 185                 190         


Thr Lys Thr Gly Ser Glu Leu Met Glu Ile Leu Asp Gly Met Asp Gln 
        195                 200                 205             


Ser His Arg Lys Glu Met Gln Leu Tyr Asn Ser Ile Phe Ser Leu Leu 
    210                 215                 220                 


Ser Phe Glu Lys Ile Gly Tyr Thr Glu Val Gln Phe Arg Pro Tyr Arg 
225                 230                 235                 240 


Thr Asp Asp Phe Ile Thr Arg Leu Tyr Tyr Glu Thr Pro Arg Phe Thr 
                245                 250                 255     


Val Leu Asn Gln Thr Trp Val Leu Lys Ala Arg Val Asn Asp Ser Glu 
            260                 265                 270         


Arg Asn Pro Asn Leu Ser Cys Lys Arg Thr Leu Ser Phe Gln Leu Leu 
        275                 280                 285             


Leu Lys Ser Lys Val Thr Ala Pro Leu Glu Cys Ser Phe Leu Leu Leu 
    290                 295                 300                 


Lys Gly Pro Tyr Asp Asp Val Arg Ile Ser Pro Val Ile Tyr His Phe 
305                 310                 315                 320 


Val Phe Thr Asn Glu Ser Asn Glu Thr Asp Tyr Val Pro Leu Pro Ile 
                325                 330                 335     


Ile Asp Ser Val Glu Cys Asn Lys Leu Leu Ala Ala Lys Asn Ile Asn 
            340                 345                 350         


Leu Arg Leu Phe Leu Phe Gln Ile Gln Lys 
        355                 360         


<210>  5759
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  5759

Met Met Ser Ala Ser Arg Leu Ala Gly Thr Leu Ile Pro Ala Met Ala 
1               5                   10                  15      


Phe Leu Ser Cys Val Arg Pro Glu Ser Trp Glu Pro Cys Val Glu Val 
            20                  25                  30          


Val Pro Asn Ile Thr Tyr Gln Cys Met Glu Leu Asn Phe Tyr Lys Ile 
        35                  40                  45              


Pro Asp Asn Leu Pro Phe Ser Thr Lys Asn Leu Asp Leu Ser Phe Asn 
    50                  55                  60                  


Pro Leu Arg His Leu Gly Ser Tyr Ser Phe Phe Ser Phe Pro Glu Leu 
65                  70                  75                  80  


Gln Val Leu Asp Leu Ser Arg Cys Glu Ile Gln Thr Ile Glu Asp Gly 
                85                  90                  95      


Ala Tyr Gln Ser Leu Ser His Leu Ser Thr Leu Ile Leu Thr Gly Asn 
            100                 105                 110         


Pro Ile Gln Ser Leu Ala Leu Gly Ala Phe Ser Gly Leu Ser Ser Leu 
        115                 120                 125             


Gln Lys Leu Val Ala Val Glu Thr Asn Leu Ala Ser Leu Glu Asn Phe 
    130                 135                 140                 


Pro Ile Gly His Leu Lys Thr Leu Lys Glu Leu Asn Val Ala His Asn 
145                 150                 155                 160 


Leu Ile Gln Ser Phe Lys Leu Pro Glu Tyr Phe Ser Asn Leu Thr Asn 
                165                 170                 175     


Leu Glu His Leu Asp Leu Ser Ser Asn Lys Ile Gln Ser Ile Tyr Cys 
            180                 185                 190         


Thr Asp Leu Arg Val Leu His Gln Met Pro Leu Leu Asn Leu Ser Leu 
        195                 200                 205             


Asp Leu Ser Leu Asn Pro Met Asn Phe Ile Gln Pro Gly Ala Phe Lys 
    210                 215                 220                 


Glu Ile Arg Leu His Lys Leu Thr Leu Arg Asn Asn Phe Asp Ser Leu 
225                 230                 235                 240 


Asn Val Met Lys Thr Cys Ile Gln Gly Leu Ala Gly Leu Glu Val His 
                245                 250                 255     


Arg Leu Val Leu Gly Glu Phe Arg Asn Glu Gly Asn Leu Glu Lys Phe 
            260                 265                 270         


Asp Lys Ser Ala Leu Glu Gly Leu Cys Asn Leu Thr Ile Glu Glu Phe 
        275                 280                 285             


Arg Leu Ala Tyr Leu Asp Tyr Tyr Leu Asp Asp Ile Ile Asp Leu Phe 
    290                 295                 300                 


Asn Cys Leu Thr Asn Val Ser Ser Phe Ser Leu Val Ser Val Thr Ile 
305                 310                 315                 320 


Glu Arg Val Lys Asp Phe Ser Tyr Asn Phe Gly Trp Gln His Leu Glu 
                325                 330                 335     


Leu Val Asn Cys Lys Phe Gly Gln Phe Pro Thr Leu Lys Leu Lys Ser 
            340                 345                 350         


Leu Lys Arg Leu Thr Phe Thr Ser Asn Lys Gly Gly Asn Ala Phe Ser 
        355                 360                 365             


Glu Val Asp Leu Pro Ser Leu Glu Phe Leu Asp Leu Ser Arg Asn Gly 
    370                 375                 380                 


Leu Ser Phe Lys Gly Cys Cys Ser Gln Ser Asp Phe Gly Thr Thr Ser 
385                 390                 395                 400 


Leu Lys Tyr Leu Asp Leu Ser Phe Asn Gly Val Ile Thr Met Ser Ser 
                405                 410                 415     


Asn Phe Leu Gly Leu Glu Gln Leu Glu His Leu Asp Phe Gln His Ser 
            420                 425                 430         


Asn Leu Lys Gln Met Ser Glu Phe Ser Val Phe Leu Ser Leu Arg Asn 
        435                 440                 445             


Leu Ile Tyr Leu Asp Ile Ser His Thr His Thr Arg Val Ala Phe Asn 
    450                 455                 460                 


Gly Ile Phe Asn Gly Leu Ser Ser Leu Glu Val Leu Lys Met Ala Gly 
465                 470                 475                 480 


Asn Ser Phe Gln Glu Asn Phe Leu Pro Asp Ile Phe Thr Glu Leu Arg 
                485                 490                 495     


Asn Leu Thr Phe Leu Asp Leu Ser Gln Cys Gln Leu Glu Gln Leu Ser 
            500                 505                 510         


Pro Thr Ala Phe Asn Ser Leu Ser Ser Leu Gln Val Leu Asn Met Ser 
        515                 520                 525             


His Asn Asn Phe Phe Ser Leu Asp Thr Phe Pro Tyr Lys Cys Leu Asn 
    530                 535                 540                 


Ser Leu Gln Val Leu Asp Tyr Ser Leu Asn His Ile Met Thr Ser Lys 
545                 550                 555                 560 


Lys Gln Glu Leu Gln His Phe Pro Ser Ser Leu Ala Phe Leu Asn Leu 
                565                 570                 575     


Thr Gln Asn Asp Phe Ala Cys Thr Cys Glu His Gln Ser Phe Leu Gln 
            580                 585                 590         


Trp Ile Lys Asp Gln Arg Gln Leu Leu Val Glu Val Glu Arg Met Glu 
        595                 600                 605             


Cys Ala Thr Pro Ser Asp Lys Gln Gly Met Pro Val Leu Ser Leu Asn 
    610                 615                 620                 


Ile Thr Cys Gln Met Asn Lys Thr Ile Ile Gly Val Ser Val Leu Ser 
625                 630                 635                 640 


Val Leu Val Val Ser Val Val Ala Val Leu Val Tyr Lys Phe Tyr Phe 
                645                 650                 655     


His Leu Met Leu Leu Ala Gly Cys Ile Lys Tyr Gly Arg Gly Glu Asn 
            660                 665                 670         


Ile Tyr Asp Ala Phe Val Ile Tyr Ser Ser Gln Asp Glu Asp Trp Val 
        675                 680                 685             


Arg Asn Glu Leu Val Lys Asn Leu Glu Glu Gly Val Pro Pro Phe Gln 
    690                 695                 700                 


Leu Cys Leu His Tyr Arg Asp Phe Ile Pro Gly Val Ala Ile Ala Ala 
705                 710                 715                 720 


Asn Ile Ile His Glu Gly Phe His Lys Ser Arg Lys Val Ile Val Val 
                725                 730                 735     


Val Ser Gln His Phe Ile Gln Ser Arg Trp Cys Ile Phe Glu Tyr Glu 
            740                 745                 750         


Ile Ala Gln Thr Trp Gln Phe Leu Ser Ser Arg Ala Gly Ile Ile Phe 
        755                 760                 765             


Ile Val Leu Gln Lys Val Glu Lys Thr Leu Leu Arg Gln Gln Val Glu 
    770                 775                 780                 


Leu Tyr Arg Leu Leu Ser Arg Asn Thr Tyr Leu Glu Trp Glu Asp Ser 
785                 790                 795                 800 


Val Leu Gly Arg His Ile Phe Trp Arg Arg Leu Arg Lys Ala Leu Leu 
                805                 810                 815     


Asp Gly Lys Ser Trp Asn Pro Glu Gly Thr Val Gly Thr Gly Cys Asn 
            820                 825                 830         


Trp Gln Glu Ala Thr Ser Ile 
        835                 


<210>  5760
<211>  780
<212>  PRT
<213>  Homo sapiens

<400>  5760

Met Thr Ala Ala Ala Ala Ser Asn Trp Gly Leu Ile Thr Asn Ile Val 
1               5                   10                  15      


Asn Ser Ile Val Gly Val Ser Val Leu Thr Met Pro Phe Cys Phe Lys 
            20                  25                  30          


Gln Cys Gly Ile Val Leu Gly Ala Leu Leu Leu Val Phe Cys Ser Trp 
        35                  40                  45              


Met Thr His Gln Ser Cys Met Phe Leu Val Lys Ser Ala Ser Leu Ser 
    50                  55                  60                  


Lys Arg Arg Thr Tyr Ala Gly Leu Ala Phe His Ala Tyr Gly Lys Ala 
65                  70                  75                  80  


Gly Lys Met Leu Val Glu Thr Ser Met Ile Gly Leu Met Leu Gly Thr 
                85                  90                  95      


Cys Ile Ala Phe Tyr Val Val Ile Gly Asp Leu Gly Ser Asn Phe Phe 
            100                 105                 110         


Ala Arg Leu Phe Gly Phe Gln Val Gly Gly Thr Phe Arg Met Phe Leu 
        115                 120                 125             


Leu Phe Ala Val Ser Leu Cys Ile Val Leu Pro Leu Ser Leu Gln Arg 
    130                 135                 140                 


Asn Met Met Ala Ser Ile Gln Ser Phe Ser Ala Met Ala Leu Leu Phe 
145                 150                 155                 160 


Tyr Thr Val Phe Met Phe Val Ile Val Leu Ser Ser Leu Lys His Gly 
                165                 170                 175     


Leu Phe Ser Gly Gln Trp Leu Arg Arg Val Ser Tyr Val Arg Trp Glu 
            180                 185                 190         


Gly Val Phe Arg Cys Ile Pro Ile Phe Gly Met Ser Phe Ala Cys Gln 
        195                 200                 205             


Ser Gln Val Leu Pro Thr Tyr Asp Ser Leu Asp Glu Pro Ser Val Lys 
    210                 215                 220                 


Thr Met Ser Ser Ile Phe Ala Ser Ser Leu Asn Val Val Thr Thr Phe 
225                 230                 235                 240 


Tyr Val Met Val Gly Phe Phe Gly Tyr Val Ser Phe Thr Glu Ala Thr 
                245                 250                 255     


Ala Gly Asn Val Leu Met His Phe Pro Ser Asn Leu Val Thr Glu Met 
            260                 265                 270         


Leu Arg Val Gly Phe Met Met Ser Val Ala Val Gly Phe Pro Met Met 
        275                 280                 285             


Ile Leu Pro Cys Arg Gln Ala Leu Ser Thr Leu Leu Cys Glu Gln Gln 
    290                 295                 300                 


Gln Lys Asp Gly Thr Phe Ala Ala Gly Gly Tyr Met Pro Pro Leu Arg 
305                 310                 315                 320 


Phe Lys Ala Leu Thr Leu Ser Val Val Phe Gly Thr Met Val Gly Gly 
                325                 330                 335     


Ile Leu Ile Pro Asn Val Glu Thr Ile Leu Gly Leu Thr Gly Ala Thr 
            340                 345                 350         


Met Gly Ser Leu Ile Cys Phe Ile Cys Pro Ala Leu Ile Tyr Lys Lys 
        355                 360                 365             


Ile His Lys Asn Ala Leu Ser Ser Gln Val Val Leu Trp Val Gly Leu 
    370                 375                 380                 


Gly Val Leu Val Val Ser Thr Val Thr Thr Leu Ser Val Ser Glu Glu 
385                 390                 395                 400 


Val Pro Glu Asp Leu Ala Glu Glu Ala Pro Gly Gly Arg Leu Gly Glu 
                405                 410                 415     


Ala Glu Gly Leu Met Lys Val Glu Ala Ala Arg Leu Ser Ala Gln Asp 
            420                 425                 430         


Pro Val Val Ala Val Ala Glu Asp Gly Arg Glu Lys Pro Lys Leu Pro 
        435                 440                 445             


Lys Glu Arg Glu Glu Leu Glu Gln Ala Gln Ile Lys Gly Pro Val Asp 
    450                 455                 460                 


Val Pro Gly Arg Glu Asp Gly Lys Glu Ala Pro Glu Glu Ala Gln Leu 
465                 470                 475                 480 


Asp Arg Pro Gly Gln Gly Ile Ala Val Pro Val Gly Glu Ala His Arg 
                485                 490                 495     


His Glu Pro Pro Val Pro His Asp Lys Val Val Val Asp Glu Gly Gln 
            500                 505                 510         


Asp Arg Glu Val Pro Glu Glu Asn Lys Pro Pro Ser Arg His Ala Gly 
        515                 520                 525             


Gly Lys Ala Pro Gly Val Gln Gly Gln Met Ala Pro Pro Leu Pro Asp 
    530                 535                 540                 


Ser Glu Arg Glu Lys Gln Glu Pro Glu Gln Gly Glu Val Gly Lys Arg 
545                 550                 555                 560 


Pro Gly Gln Ala Gln Ala Leu Glu Glu Ala Gly Asp Leu Pro Glu Asp 
                565                 570                 575     


Pro Gln Lys Val Pro Glu Ala Asp Gly Gln Pro Ala Val Gln Pro Ala 
            580                 585                 590         


Lys Glu Asp Leu Gly Pro Gly Asp Arg Gly Leu His Pro Arg Pro Gln 
        595                 600                 605             


Ala Val Leu Ser Glu Gln Gln Asn Gly Leu Ala Val Gly Gly Gly Glu 
    610                 615                 620                 


Lys Ala Lys Gly Gly Pro Pro Pro Gly Asn Ala Ala Gly Asp Thr Gly 
625                 630                 635                 640 


Gln Pro Ala Glu Asp Ser Asp His Gly Gly Lys Pro Pro Leu Pro Ala 
                645                 650                 655     


Glu Lys Pro Ala Pro Gly Pro Gly Leu Pro Pro Glu Pro Arg Glu Gln 
            660                 665                 670         


Arg Asp Val Glu Arg Ala Gly Gly Asn Gln Ala Ala Ser Gln Leu Glu 
        675                 680                 685             


Gly Lys Ala Ser Ala Leu Gln Pro Pro Ala Ser Gly Pro Gly Ser Gly 
    690                 695                 700                 


Ser Pro Leu Pro Gln Pro Trp Gly Asp Ala Gln Val Ile Leu Gly Ser 
705                 710                 715                 720 


Pro Ala Arg Pro Pro Phe Ser Phe Gln Pro Pro Ala Glu Gln Thr Pro 
                725                 730                 735     


Arg Arg Ala Phe Cys Ser Leu Pro Ile Ser Ser Leu Leu Ser Gly Asn 
            740                 745                 750         


Leu Leu Ser Ala Leu Leu Pro Phe Lys His Leu Arg His Arg His Met 
        755                 760                 765             


Ala Cys Asp Tyr Arg Phe Ile Ser Leu Ala Pro Leu 
    770                 775                 780 


<210>  5761
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  5761

Met Pro Thr Asp His Glu Glu Pro Cys Gly Pro Ser His Lys Ser Phe 
1               5                   10                  15      


Cys Leu Asn Gly Gly Leu Cys Tyr Val Ile Pro Thr Ile Pro Ser Pro 
            20                  25                  30          


Phe Cys Arg Cys Val Glu Asn Tyr Thr Gly Ala Arg Cys Glu Glu Val 
        35                  40                  45              


Phe Leu Pro Gly Ser Ser Ile Gln Thr Lys Ser Asn Leu Phe Glu Ala 
    50                  55                  60                  


Phe Val Ala Leu Ala Val Leu Val Thr Leu Ile Ile Gly Ala Phe Tyr 
65                  70                  75                  80  


Phe Leu Cys Arg Lys Gly His Phe Gln Arg Ala Ser Ser Val Gln Tyr 
                85                  90                  95      


Asp Ile Asn Leu Val Glu Thr Ser Ser Thr Ser Ala His His Ser His 
            100                 105                 110         


Glu Gln His 
        115 


<210>  5762
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  5762

Met Ala Phe Arg Gln Ala Leu Gln Leu Ala Ala Cys Gly Leu Ala Gly 
1               5                   10                  15      


Gly Ser Ala Ala Val Leu Phe Ser Ala Val Ala Val Gly Lys Pro Arg 
            20                  25                  30          


Ala Gly Gly Asp Ala Glu Pro Arg Pro Ala Glu Pro Pro Ala Trp Ala 
        35                  40                  45              


Gly Gly Ala Arg Pro Gly Pro Gly Val Trp Asp Pro Asn Trp Asp Arg 
    50                  55                  60                  


Arg Glu Pro Leu Ser Leu Ile Asn Val Arg Lys Arg Asn Val Glu Ser 
65                  70                  75                  80  


Gly Glu Glu Glu Leu Ala Ser Lys Leu Asp His Tyr Lys Ala Lys Ala 
                85                  90                  95      


Thr Arg His Ile Phe Leu Ile Arg His Ser Gln Tyr His Val Asp Gly 
            100                 105                 110         


Ser Leu Glu Lys Asp Arg Thr Leu Thr Pro Leu Gly Arg Glu Gln Ala 
        115                 120                 125             


Glu Leu Thr Gly Leu Arg Leu Ala Ser Leu Gly Leu Lys Phe Asn Lys 
    130                 135                 140                 


Ile Val His Ser Ser Met Thr Arg Ala Ile Glu Thr Thr Asp Ile Ile 
145                 150                 155                 160 


Ser Arg His Leu Pro Gly Val Cys Lys Val Ser Thr Asp Leu Leu Arg 
                165                 170                 175     


Glu Gly Ala Pro Ile Glu Pro Asp Pro Pro Val Ser His Trp Lys Pro 
            180                 185                 190         


Glu Ala Val Gln Tyr Tyr Glu Asp Gly Ala Arg Ile Glu Ala Ala Phe 
        195                 200                 205             


Arg Asn Tyr Ile His Arg Ala Asp Ala Arg Gln Glu Glu Asp Ser Tyr 
    210                 215                 220                 


Glu Ile Phe Ile Cys His Ala Asn Val Ile Arg Tyr Ile Val Cys Ser 
225                 230                 235                 240 


Ile Pro Pro Leu Leu Ser Ala Gly Asp Phe Val Leu Leu Gly Ser 
                245                 250                 255 


<210>  5763
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  5763

Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
1               5                   10                  15      


Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
            20                  25                  30          


Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Met Glu Thr Pro 
        35                  40                  45              


Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala 
    50                  55                  60                  


Val Asn Gly Ala Thr Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val 
65                  70                  75                  80  


Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu 
                85                  90                  95      


Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu 
            100                 105                 110         


His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn 
        115                 120                 125             


Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe 
    130                 135                 140                 


Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln 
145                 150                 155                 160 


Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp 
                165                 170                 175     


His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val 
            180                 185                 190         


Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu 
        195                 200                 205             


Arg Phe Asn Arg Trp Phe Leu Thr Gly Met Thr Val Ala Gly Val Val 
    210                 215                 220                 


Leu Leu Gly Ser Leu Phe Ser Arg Lys 
225                 230             


<210>  5764
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  5764

Met Pro Val Gln Leu Thr Thr Ala Leu Arg Val Val Gly Thr Ser Leu 
1               5                   10                  15      


Phe Ala Leu Ala Val Leu Gly Gly Ile Leu Ala Ala Tyr Val Thr Gly 
            20                  25                  30          


Tyr Gln Phe Ile His Thr Glu Lys His Tyr Leu Ser Phe Gly Leu Tyr 
        35                  40                  45              


Gly Ala Ile Leu Gly Leu His Leu Leu Ile Gln Ser Leu Phe Ala Phe 
    50                  55                  60                  


Leu Glu His Arg Arg Met Arg Arg Ala Gly Gln Ala Leu Lys Leu Pro 
65                  70                  75                  80  


Ser Pro Arg Arg Gly Ser Val Ala Leu Cys Ile Ala Ala Tyr Gln Glu 
                85                  90                  95      


Asp Pro Asp Tyr Leu Arg Lys Cys Leu Arg Ser Ala Gln Arg Ile Ser 
            100                 105                 110         


Phe Pro Asp Leu Lys Val Val Met Val Val Asp Gly Asn Arg Gln Glu 
        115                 120                 125             


Asp Ala Tyr Met Leu Asp Ile Phe His Glu Val Leu Gly Gly Thr Glu 
    130                 135                 140                 


Gln Ala Gly Phe Phe Val Trp Arg Ser Asn Phe His Glu Ala Gly Glu 
145                 150                 155                 160 


Gly Glu Thr Glu Ala Ser Leu Gln Glu Gly Met Asp Arg Val Arg Asp 
                165                 170                 175     


Val Val Arg Ala Ser Thr Phe Ser Cys Ile Met Gln Lys Trp Gly Gly 
            180                 185                 190         


Lys Arg Glu Val Met Tyr Thr Ala Phe Lys Ala Leu Gly Asp Ser Val 
        195                 200                 205             


Asp Tyr Ile Gln Val Cys Asp Ser Asp Thr Val Leu Asp Pro Ala Cys 
    210                 215                 220                 


Thr Ile Glu Met Leu Arg Val Leu Glu Glu Asp Pro Gln Val Gly Gly 
225                 230                 235                 240 


Val Gly Gly Asp Val Gln Pro Pro Gly Lys Gly Met Ala Val Glu Asp 
                245                 250                 255     


Asp Gln Val Gln Ala Ala Gln Val Arg Ala Thr Glu Ala Trp Ser Val 
            260                 265                 270         


His Gln Arg His Val Ser Arg Glu Gln 
        275                 280     


<210>  5765
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  5765

Met Ser Ser Lys Tyr Pro Arg Ser Val Arg Arg Cys Leu Pro Leu Trp 
1               5                   10                  15      


Ala Leu Thr Leu Glu Ala Ala Leu Ile Leu Leu Phe Tyr Phe Phe Thr 
            20                  25                  30          


His Tyr Asp Ala Ser Leu Glu Asp Gln Lys Gly Leu Val Ala Ser Tyr 
        35                  40                  45              


Gln Val Gly Gln Asp Leu Thr Val Met Ala Ala Leu Gly Leu Gly Phe 
    50                  55                  60                  


Leu Thr Ser Asn Phe Arg Arg His Ser Trp Ser Ser Val Ala Phe Asn 
65                  70                  75                  80  


Leu Phe Met Leu Ala Leu Gly Val Gln Trp Ala Ile Leu Leu Asp Gly 
                85                  90                  95      


Phe Leu Ser Gln Phe Pro Pro Gly Lys Val Val Ile Thr Leu Phe Ser 
            100                 105                 110         


Ile Arg Leu Ala Thr Met Ser Ala Met Ser Val Leu Ile Ser Ala Gly 
        115                 120                 125             


Ala Val Leu Gly Lys Val Asn Leu Ala Gln Leu Val Val Met Val Leu 
    130                 135                 140                 


Val Glu Val Thr Ala Leu Gly Thr Leu Arg Met Val Ile Ser Asn Ile 
145                 150                 155                 160 


Phe Asn Val Cys Cys Asn Arg Val Leu Gly Ile His His Ile Ser Val 
                165                 170                 175     


Met His Ser Ile Phe Ser Leu Leu Gly Leu Leu Gly Glu Ile Thr Tyr 
            180                 185                 190         


Ile Val Leu Leu Val Leu His Thr Val Trp Asn Gly Asn Gly Met Ile 
        195                 200                 205             


Gly Phe Gln Val Leu Leu Ser Ile Gly Glu Leu Ser Leu Ala Ile Val 
    210                 215                 220                 


Ile Ala Leu Thr Ser Gly Leu Leu Thr Gly Leu Leu Leu Asn Leu Lys 
225                 230                 235                 240 


Ile Trp Lys Ala Pro His Val Ala Lys Tyr Phe Asp Asp Gln Val Phe 
                245                 250                 255     


Trp Lys Phe Pro His Leu Ala Val Gly Phe 
            260                 265     


<210>  5766
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  5766

Met Ser Ser Lys Tyr Pro Arg Ser Val Arg Arg Cys Leu Pro Leu Trp 
1               5                   10                  15      


Ala Leu Thr Leu Glu Ala Ala Leu Ile Leu Leu Phe Tyr Phe Phe Thr 
            20                  25                  30          


His Tyr Asp Ala Ser Leu Glu Asp Gln Lys Gly Leu Val Ala Ser Tyr 
        35                  40                  45              


Gln Val Gly Gln Asp Leu Thr Val Met Ala Ala Leu Gly Leu Gly Phe 
    50                  55                  60                  


Leu Thr Ser Asn Phe Arg Arg His Ser Trp Ser Ser Val Ala Phe Asn 
65                  70                  75                  80  


Leu Phe Met Leu Ala Leu Gly Val Gln Trp Ala Ile Leu Leu Asp Gly 
                85                  90                  95      


Phe Leu Ser Gln Phe Pro Pro Gly Lys Val Val Ile Thr Leu Phe Ser 
            100                 105                 110         


Ile Arg Leu Ala Thr Met Ser Ala Met Ser Val Leu Ile Ser Ala Gly 
        115                 120                 125             


Ala Val Leu Gly Lys Val Asn Leu Ala Gln Leu Val Val Met Val Leu 
    130                 135                 140                 


Val Glu Val Thr Ala Leu Gly Thr Leu Arg Met Val Ile Ser Asn Ile 
145                 150                 155                 160 


Phe Asn Thr Tyr Val His Ser Ala Val Leu Ala Gly Gly Val Ala Val 
                165                 170                 175     


Gly Thr Ser Cys His Leu Ile Pro Ser Pro Trp Leu Ala Met Val Leu 
            180                 185                 190         


Gly Leu Val Ala Gly Leu Ile Ser Ile Gly Gly Ala Lys Cys Leu Pro 
        195                 200                 205             


Val Cys Cys Asn Arg Val Leu Gly Ile His His Ile Ser Val Met His 
    210                 215                 220                 


Ser Ile Phe Ser Leu Leu Gly Leu Leu Gly Glu Ile Thr Tyr Ile Val 
225                 230                 235                 240 


Leu Leu Val Leu His Thr Val Trp Asn Gly Asn Gly Met Phe Ala Pro 
                245                 250                 255     


Lys Ser Gln Asn Met Glu Ser Thr Ser Cys Gly 
            260                 265         


<210>  5767
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  5767

Met Ser Ser Lys Tyr Pro Arg Ser Val Arg Arg Cys Leu Pro Leu Trp 
1               5                   10                  15      


Ala Leu Thr Leu Glu Ala Ala Leu Ile Leu Leu Phe Tyr Phe Phe Thr 
            20                  25                  30          


His Tyr Asp Ala Ser Leu Glu Asp Gln Lys Gly Leu Val Ala Ser Tyr 
        35                  40                  45              


Gln Val Gly Gln Asp Leu Thr Val Met Ala Ala Leu Gly Leu Gly Phe 
    50                  55                  60                  


Leu Thr Ser Asn Phe Arg Arg His Ser Trp Ser Ser Val Ala Phe Asn 
65                  70                  75                  80  


Leu Phe Met Leu Ala Leu Gly Val Gln Trp Ala Ile Leu Leu Asp Gly 
                85                  90                  95      


Phe Leu Ser Gln Phe Pro Pro Gly Lys Val Val Ile Thr Leu Phe Ser 
            100                 105                 110         


Ile Arg Leu Ala Thr Met Ser Ala Met Ser Val Leu Ile Ser Ala Gly 
        115                 120                 125             


Ala Val Leu Gly Lys Val Asn Leu Ala Gln Leu Val Val Met Val Leu 
    130                 135                 140                 


Val Glu Val Thr Ala Leu Gly Thr Leu Arg Met Val Ile Ser Asn Ile 
145                 150                 155                 160 


Phe Asn Thr Asp Tyr His Met Asn Leu Arg His Phe Tyr Val Phe Ala 
                165                 170                 175     


Ala Tyr Phe Gly Leu Thr Val Ala Trp Cys Leu Pro Lys Pro Leu Pro 
            180                 185                 190         


Lys Gly Thr Glu Asp Asn Asp Gln Arg Ala Thr Ile Pro Ser Leu Ser 
        195                 200                 205             


Ala Met Leu Gly Ala Leu Phe Leu Trp Met Phe Trp Pro Ser Val Asn 
    210                 215                 220                 


Ser Ala Leu Leu Arg Ser Pro Ile Gln Arg Lys Asn Ala Met Phe Asn 
225                 230                 235                 240 


Thr Tyr Tyr Ala Leu Ala Val Ser Val Val Thr Ala Ile Ser Gly Ser 
                245                 250                 255     


Ser Leu Ala His Pro Gln Arg Lys Ile Ser Met Thr Tyr Val His Ser 
            260                 265                 270         


Ala Val Leu Ala Gly Gly Val Ala Val Gly Thr Ser Cys His Leu Ile 
        275                 280                 285             


Pro Ser Pro Trp Leu Ala Met Val Leu Gly Leu Val Ala Gly Leu Ile 
    290                 295                 300                 


Ser Ile Gly Gly Ala Lys Cys Leu Pro Asp Trp Leu Pro Gly Pro Pro 
305                 310                 315                 320 


Gln His Trp Gly Thr Gln Leu Gly His Arg Asp Ser Ser His Val Trp 
                325                 330                 335     


Ser Pro Asp Arg Phe Ala Pro Lys Ser Gln Asn Met Glu Ser Thr Ser 
            340                 345                 350         


Cys Gly 
        


<210>  5768
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  5768

Met Asn Val Leu Leu Gly Ser Val Val Ile Phe Ala Thr Phe Val Thr 
1               5                   10                  15      


Leu Cys Asn Ala Ser Cys Tyr Phe Ile Pro Asn Glu Gly Val Pro Gly 
            20                  25                  30          


Asp Ser Thr Arg Met Phe Leu His Leu Trp Val Met Thr Lys Thr Thr 
        35                  40                  45              


Ala Lys Glu Ser Ser Arg Arg Arg Thr Ala Ser Ile Ser Trp Trp Arg 
    50                  55                  60                  


Arg Arg Thr Gln Lys Arg Pro Val Leu Ser Val Asn Gly 
65                  70                  75          


<210>  5769
<211>  1043
<212>  PRT
<213>  Homo sapiens

<400>  5769

Met Glu Phe Val Arg Ala Leu Trp Leu Gly Leu Ala Leu Ala Leu Gly 
1               5                   10                  15      


Pro Gly Ser Ala Gly Gly His Pro Gln Pro Cys Gly Val Leu Ala Arg 
            20                  25                  30          


Leu Gly Gly Ser Val Arg Leu Gly Ala Leu Leu Pro Arg Ala Pro Leu 
        35                  40                  45              


Ala Arg Ala Arg Ala Arg Ala Ala Leu Ala Arg Ala Ala Leu Ala Pro 
    50                  55                  60                  


Arg Leu Pro His Asn Leu Ser Leu Glu Leu Val Val Ala Ala Pro Pro 
65                  70                  75                  80  


Ala Arg Asp Pro Ala Ser Leu Thr Arg Gly Leu Cys Gln Ala Leu Val 
                85                  90                  95      


Pro Pro Gly Val Ala Ala Leu Leu Ala Phe Pro Glu Ala Arg Pro Glu 
            100                 105                 110         


Leu Leu Gln Leu His Phe Leu Ala Ala Ala Thr Glu Thr Pro Val Leu 
        115                 120                 125             


Ser Leu Leu Arg Arg Glu Ala Arg Ala Pro Leu Gly Ala Pro Asn Pro 
    130                 135                 140                 


Phe His Leu Gln Leu His Trp Ala Ser Pro Leu Glu Thr Leu Leu Asp 
145                 150                 155                 160 


Val Leu Val Ala Val Leu Gln Ala His Ala Trp Glu Asp Val Gly Leu 
                165                 170                 175     


Ala Leu Cys Arg Thr Gln Asp Pro Gly Gly Leu Val Ala Leu Trp Thr 
            180                 185                 190         


Ser Arg Ala Gly Arg Pro Pro Gln Leu Val Leu Asp Leu Ser Arg Arg 
        195                 200                 205             


Asp Thr Gly Asp Ala Gly Leu Arg Ala Arg Leu Ala Pro Met Ala Ala 
    210                 215                 220                 


Pro Val Gly Gly Glu Ala Pro Val Pro Ala Ala Val Leu Leu Gly Cys 
225                 230                 235                 240 


Asp Ile Ala Arg Ala Arg Arg Val Leu Glu Ala Val Pro Pro Gly Pro 
                245                 250                 255     


His Trp Leu Leu Gly Thr Pro Leu Pro Pro Lys Ala Leu Pro Thr Ala 
            260                 265                 270         


Gly Leu Pro Pro Gly Leu Leu Ala Leu Gly Glu Val Ala Arg Pro Pro 
        275                 280                 285             


Leu Glu Ala Ala Ile His Asp Ile Val Gln Leu Val Ala Arg Ala Leu 
    290                 295                 300                 


Gly Ser Ala Ala Gln Val Gln Pro Lys Arg Ala Leu Leu Pro Ala Pro 
305                 310                 315                 320 


Val Asn Cys Gly Asp Leu Gln Pro Ala Gly Pro Glu Ser Pro Gly Arg 
                325                 330                 335     


Phe Leu Ala Arg Phe Leu Ala Asn Thr Ser Phe Gln Gly Arg Thr Gly 
            340                 345                 350         


Pro Val Trp Val Thr Gly Ser Ser Gln Val His Met Ser Arg His Phe 
        355                 360                 365             


Lys Val Trp Ser Leu Arg Arg Asp Pro Arg Gly Ala Pro Ala Trp Ala 
    370                 375                 380                 


Thr Val Gly Ser Trp Arg Asp Gly Gln Leu Asp Leu Glu Pro Gly Gly 
385                 390                 395                 400 


Ala Ser Ala Arg Pro Pro Pro Pro Gln Gly Ala Gln Val Trp Pro Lys 
                405                 410                 415     


Leu Arg Val Val Thr Leu Leu Glu His Pro Phe Val Phe Ala Arg Asp 
            420                 425                 430         


Pro Asp Glu Asp Gly Gln Cys Pro Ala Gly Gln Leu Cys Leu Asp Pro 
        435                 440                 445             


Gly Thr Asn Asp Ser Ala Thr Leu Asp Ala Leu Phe Ala Ala Leu Ala 
    450                 455                 460                 


Asn Gly Ser Ala Pro Arg Ala Leu Arg Lys Cys Cys Tyr Gly Tyr Cys 
465                 470                 475                 480 


Ile Asp Leu Leu Glu Arg Leu Ala Glu Asp Thr Pro Phe Asp Phe Glu 
                485                 490                 495     


Leu Tyr Leu Val Gly Asp Gly Lys Tyr Gly Ala Leu Arg Asp Gly Arg 
            500                 505                 510         


Trp Thr Gly Leu Val Gly Asp Leu Leu Ala Gly Arg Ala His Met Ala 
        515                 520                 525             


Val Thr Ser Phe Ser Ile Asn Ser Ala Arg Ser Gln Val Val Asp Phe 
    530                 535                 540                 


Thr Ser Pro Phe Phe Ser Thr Ser Leu Gly Ile Met Val Arg Ala Arg 
545                 550                 555                 560 


Asp Thr Ala Ser Pro Ile Gly Ala Phe Met Trp Pro Leu His Trp Ser 
                565                 570                 575     


Thr Trp Leu Gly Val Phe Ala Ala Leu His Leu Thr Ala Leu Phe Leu 
            580                 585                 590         


Thr Val Tyr Glu Trp Arg Ser Pro Tyr Gly Leu Thr Pro Arg Gly Arg 
        595                 600                 605             


Asn Arg Ser Thr Val Phe Ser Tyr Ser Ser Ala Leu Asn Leu Cys Tyr 
    610                 615                 620                 


Ala Ile Leu Phe Arg Arg Thr Val Ser Ser Lys Thr Pro Lys Cys Pro 
625                 630                 635                 640 


Thr Gly Arg Leu Leu Met Asn Leu Trp Ala Ile Phe Cys Leu Leu Val 
                645                 650                 655     


Leu Ser Ser Tyr Thr Ala Asn Leu Ala Ala Val Met Val Gly Asp Lys 
            660                 665                 670         


Thr Phe Glu Glu Leu Ser Gly Ile His Asp Pro Lys Leu His His Pro 
        675                 680                 685             


Ala Gln Gly Phe Arg Phe Gly Thr Val Trp Glu Ser Ser Ala Glu Ala 
    690                 695                 700                 


Tyr Ile Lys Lys Ser Phe Pro Asp Met His Ala His Met Arg Arg His 
705                 710                 715                 720 


Ser Ala Pro Thr Thr Pro Arg Gly Val Ala Met Leu Thr Ser Asp Pro 
                725                 730                 735     


Pro Lys Leu Asn Ala Phe Ile Met Asp Lys Ser Leu Leu Asp Tyr Glu 
            740                 745                 750         


Val Ser Ile Asp Ala Asp Cys Lys Leu Leu Thr Val Gly Lys Pro Phe 
        755                 760                 765             


Ala Ile Glu Gly Tyr Gly Ile Gly Leu Pro Gln Asn Ser Pro Leu Thr 
    770                 775                 780                 


Ser Asn Leu Ser Glu Phe Ile Ser Arg Tyr Lys Ser Ser Gly Phe Ile 
785                 790                 795                 800 


Asp Leu Leu His Asp Lys Trp Tyr Lys Met Val Pro Cys Gly Lys Arg 
                805                 810                 815     


Val Phe Ala Val Thr Glu Thr Leu Gln Met Ser Ile Tyr His Phe Ala 
            820                 825                 830         


Gly Leu Phe Val Leu Leu Cys Leu Gly Leu Gly Ser Ala Leu Leu Ser 
        835                 840                 845             


Ser Leu Gly Glu His Ala Phe Phe Arg Leu Ala Leu Pro Arg Ile Arg 
    850                 855                 860                 


Lys Gly Ser Arg Leu Gln Tyr Trp Leu His Thr Ser Gln Lys Ile His 
865                 870                 875                 880 


Arg Ala Leu Asn Thr Glu Pro Pro Glu Gly Ser Lys Glu Glu Thr Ala 
                885                 890                 895     


Glu Ala Glu Pro Ser Gly Pro Glu Val Glu Gln Gln Gln Gln Gln Gln 
            900                 905                 910         


Asp Gln Pro Thr Ala Pro Glu Gly Trp Lys Arg Ala Arg Arg Ala Val 
        915                 920                 925             


Asp Lys Glu Arg Arg Val Arg Phe Leu Leu Glu Pro Ala Val Val Val 
    930                 935                 940                 


Ala Pro Glu Ala Asp Ala Glu Ala Glu Ala Ala Pro Arg Glu Gly Pro 
945                 950                 955                 960 


Val Trp Leu Cys Ser Tyr Gly Arg Pro Pro Ala Ala Arg Pro Thr Gly 
                965                 970                 975     


Ala Pro Gln Pro Gly Glu Leu Gln Glu Leu Glu Arg Arg Ile Glu Val 
            980                 985                 990         


Ala Arg Glu Arg Leu Arg Gln Ala  Leu Val Arg Arg Gly  Gln Leu Leu 
        995                 1000                 1005             


Ala Gln  Leu Gly Asp Ser Ala  Arg His Arg Pro Arg  Arg Leu Leu 
    1010                 1015                 1020             


Gln Ala  Arg Ala Ala Pro Ala  Glu Ala Pro Pro His  Ser Gly Arg 
    1025                 1030                 1035             


Pro Gly  Ser Gln Glu 
    1040             


<210>  5770
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  5770

Met Ser Pro Lys Lys Val Gln Ile Lys Val Glu Glu Lys Glu Asp Glu 
1               5                   10                  15      


Thr Glu Glu Ser Ser Ser Glu Glu Glu Glu Glu Val Glu Asp Lys Leu 
            20                  25                  30          


Pro Arg Arg Glu Ser Leu Arg Pro Lys Arg Lys Arg Thr Arg Asp Val 
        35                  40                  45              


Ile Asn Glu Asp Asp Pro Glu Pro Glu Pro Glu Asp Glu Glu Thr Arg 
    50                  55                  60                  


Lys Ala Arg Glu Lys Glu Arg Arg Arg Arg Leu Lys Arg Gly Ala Glu 
65                  70                  75                  80  


Glu Glu Glu Ile Asp Glu Glu Glu Leu Glu Arg Leu Lys Ala Glu Leu 
                85                  90                  95      


Asp Glu Lys Arg Gln Ile Ile Ala Thr Val Lys Cys Lys Pro Trp Lys 
            100                 105                 110         


Met Glu Lys Lys Ile Glu Val Leu Lys Glu Ala Lys Lys Phe Val Ser 
        115                 120                 125             


Glu Asn Glu Gly Ala Leu Gly Lys Gly Lys Gly Lys Arg Trp Phe Ala 
    130                 135                 140                 


Phe Lys Met Met Met Ala Lys Lys Trp Ala Lys Phe Leu Arg Asp Phe 
145                 150                 155                 160 


Glu Asn Phe Lys Ala Ala Cys Val Pro Trp Glu Asn Lys Ile Lys Ala 
                165                 170                 175     


Ile Glu Ser Gln Phe Gly Ser Ser Val Ala Ser Tyr Phe Leu Phe Leu 
            180                 185                 190         


Arg Trp Met Tyr Gly Val Asn Met Val Leu Phe Ile Leu Thr Phe Ser 
        195                 200                 205             


Leu Ile Met Leu Pro Glu Tyr Leu Trp Gly Leu Pro Tyr Gly Ser Leu 
    210                 215                 220                 


Pro Arg Lys Thr Val Pro Arg Ala Glu Glu Ala Ser Ala Ala Asn Phe 
225                 230                 235                 240 


Gly Val Leu Tyr Asp Phe Asn Gly Leu Ala Gln Tyr Ser Val Leu Phe 
                245                 250                 255     


Tyr Gly Tyr Tyr Asp Asn Lys Arg Thr Ile Gly Trp Met Asn Phe Arg 
            260                 265                 270         


Leu Pro Leu Ser Tyr Phe Leu Val Gly Ile Met Cys Ile Gly Tyr Ser 
        275                 280                 285             


Phe Leu Val Val Leu Lys Ala Met Thr Lys Asn Ile Gly Asp Asp Gly 
    290                 295                 300                 


Gly Gly Asp Asp Asn Thr Phe Asn Phe Ser Trp Lys Val Phe Thr Ser 
305                 310                 315                 320 


Trp Asp Tyr Leu Ile Gly Asn Pro Glu Thr Ala Asp Asn Lys Phe Asn 
                325                 330                 335     


Ser Ile Thr Met Asn Phe Lys Glu Ala Ile Thr Glu Glu Lys Ala Ala 
            340                 345                 350         


Gln Val Glu Glu Asn Val His Leu Ile Arg Phe Leu Arg Phe Leu Ala 
        355                 360                 365             


Asn Phe Phe Val Phe Leu Thr Leu Gly Gly Ser Gly Tyr Leu Ile Phe 
    370                 375                 380                 


Trp Ala Val Lys Arg Ser Gln Glu Phe Ala Gln Gln Asp Pro Asp Thr 
385                 390                 395                 400 


Leu Gly Trp Trp Glu Lys Asn Glu Met Asn Met Val Met Ser Leu Leu 
                405                 410                 415     


Gly Met Phe Cys Pro Thr Leu Phe Asp Leu Phe Ala Glu Leu Glu Asp 
            420                 425                 430         


Tyr His Pro Leu Ile Ala Leu Lys Trp Leu Leu Gly Arg Ile Phe Ala 
        435                 440                 445             


Leu Leu Leu Gly Asn Leu Tyr Val Phe Ile Leu Ala Leu Met Asp Glu 
    450                 455                 460                 


Ile Asn Asn Lys Ile Glu Glu Glu Lys Leu Val Lys Ala Asn Ile Thr 
465                 470                 475                 480 


Leu Trp Glu Ala Asn Met Ile Lys Ala Tyr Asn Ala Ser Phe Ser Glu 
                485                 490                 495     


Asn Ser Thr Gly Pro Pro Phe Phe Val His Pro Ala Asp Val Pro Arg 
            500                 505                 510         


Gly Pro Cys Trp Glu Thr Met Val Gly Gln Glu Phe Val Arg Leu Thr 
        515                 520                 525             


Val Ser Asp Val Leu Thr Thr Tyr Val Thr Ile Leu Ile Gly Asp Phe 
    530                 535                 540                 


Leu Arg Ala Cys Phe Val Arg Phe Cys Asn Tyr Cys Trp Cys Trp Asp 
545                 550                 555                 560 


Leu Glu Tyr Gly Tyr Pro Ser Tyr Thr Glu Phe Asp Ile Ser Gly Asn 
                565                 570                 575     


Val Leu Ala Leu Ile Phe Asn Gln Gly Met Ile Trp Met Gly Ser Phe 
            580                 585                 590         


Phe Ala Pro Ser Leu Pro Gly Ile Asn Ile Leu Arg Leu His Thr Ser 
        595                 600                 605             


Met Tyr Phe Gln Cys Trp Ala Val Met Cys Cys Asn Val Pro Glu Ala 
    610                 615                 620                 


Arg Val Phe Lys Ala Ser Arg Ser Asn Asn Phe Tyr Leu Gly Met Leu 
625                 630                 635                 640 


Leu Leu Ile Leu Phe Leu Ser Thr Met Pro Val Leu Tyr Met Ile Val 
                645                 650                 655     


Ser Leu Pro Pro Ser Phe Asp Cys Gly Pro Phe Ser Gly Lys Asn Arg 
            660                 665                 670         


Met Phe Glu Val Ile Gly Glu Thr Leu Glu His Asp Phe Pro Ser Trp 
        675                 680                 685             


Met Ala Lys Ile Leu Arg Gln Leu Ser Asn Pro Gly Leu Val Ile Ala 
    690                 695                 700                 


Val Ile Leu Val Met Val Leu Ala Ile Tyr Tyr Leu Asn Ala Thr Ala 
705                 710                 715                 720 


Lys Gly Gln Lys Ala Ala Asn Leu Asp Leu Lys Lys Lys Met Lys Met 
                725                 730                 735     


Gln Ala Leu Glu Asn Lys Met Arg Asn Lys Lys Met Ala Ala Ala Arg 
            740                 745                 750         


Ala Ala Ala Ala Ala Gly Arg Gln 
        755                 760 


<210>  5771
<211>  4074
<212>  PRT
<213>  Homo sapiens

<400>  5771

Met Thr Ala Trp Leu Ile Ser Leu Met Ser Ile Glu Val Leu Leu Leu 
1               5                   10                  15      


Ala Val Arg His Leu Ser Leu His Ile Glu Pro Glu Glu Gly Ser Leu 
            20                  25                  30          


Ala Gly Gly Thr Trp Ile Thr Val Ile Phe Asp Gly Leu Glu Leu Gly 
        35                  40                  45              


Val Leu Tyr Pro Asn Asn Gly Ser Gln Leu Glu Ile His Leu Val Asn 
    50                  55                  60                  


Val Asn Met Val Val Pro Ala Leu Arg Ser Val Pro Cys Asp Val Phe 
65                  70                  75                  80  


Pro Val Phe Leu Asp Leu Pro Val Val Thr Cys Arg Thr Arg Ser Val 
                85                  90                  95      


Leu Ser Glu Ala His Glu Gly Leu Tyr Phe Leu Glu Ala Tyr Phe Gly 
            100                 105                 110         


Gly Gln Leu Val Ser Ser Pro Asn Pro Gly Pro Arg Asp Ser Cys Thr 
        115                 120                 125             


Phe Lys Phe Ser Lys Ala Gln Thr Pro Ile Val His Gln Val Tyr Pro 
    130                 135                 140                 


Pro Ser Gly Val Pro Gly Lys Leu Ile His Val Tyr Gly Trp Ile Ile 
145                 150                 155                 160 


Thr Gly Arg Leu Glu Thr Phe Asp Phe Asp Ala Glu Tyr Ile Asp Ser 
                165                 170                 175     


Pro Val Ile Leu Glu Ala Gln Gly Asp Lys Trp Val Thr Pro Cys Ser 
            180                 185                 190         


Leu Ile Asn Arg Gln Met Gly Ser Cys Tyr Pro Ile Gln Glu Asp His 
        195                 200                 205             


Gly Leu Gly Thr Leu Gln Cys His Val Glu Gly Asp Tyr Ile Gly Ser 
    210                 215                 220                 


Gln Asn Val Ser Phe Ser Val Phe Asn Lys Gly Lys Ser Met Val His 
225                 230                 235                 240 


Lys Lys Ala Trp Leu Ile Ser Ala Lys Gln Asp Leu Phe Leu Tyr Gln 
                245                 250                 255     


Thr His Ser Glu Ile Leu Ser Val Phe Pro Glu Thr Gly Ser Leu Gly 
            260                 265                 270         


Gly Arg Thr Asn Ile Thr Ile Thr Gly Asp Phe Phe Asp Asn Ser Ala 
        275                 280                 285             


Gln Val Thr Ile Ala Gly Ile Pro Cys Asp Ile Arg His Val Ser Pro 
    290                 295                 300                 


Arg Lys Ile Glu Cys Thr Thr Arg Ala Pro Gly Lys Asp Val Arg Leu 
305                 310                 315                 320 


Thr Thr Pro Gln Pro Gly Asn Arg Gly Leu Leu Phe Glu Val Gly Asp 
                325                 330                 335     


Ala Val Glu Gly Leu Glu Leu Thr Glu Ala Thr Pro Gly Tyr Arg Trp 
            340                 345                 350         


Gln Ile Val Pro Asn Ala Ser Ser Pro Phe Gly Phe Trp Ser Gln Glu 
        355                 360                 365             


Gly Gln Pro Phe Arg Ala Arg Leu Ser Gly Phe Phe Val Ala Pro Glu 
    370                 375                 380                 


Thr Asn Asn Tyr Thr Phe Trp Ile Gln Ala Asp Ser Gln Ala Ser Leu 
385                 390                 395                 400 


His Phe Ser Trp Ser Glu Glu Pro Arg Thr Lys Val Lys Val Ala Ser 
                405                 410                 415     


Ile Ser Val Gly Thr Ala Asp Trp Phe Asp Ser Trp Glu Gln Asn Arg 
            420                 425                 430         


Asp Glu Gly Thr Trp Gln Gln Lys Thr Pro Lys Leu Glu Leu Leu Gly 
        435                 440                 445             


Gly Ala Met Tyr Tyr Leu Glu Ala Glu His His Gly Ile Ala Pro Ser 
    450                 455                 460                 


Arg Gly Met Arg Ile Gly Val Gln Ile His Asn Thr Trp Leu Asn Pro 
465                 470                 475                 480 


Asp Val Val Thr Thr Tyr Leu Arg Glu Lys His Gln Ile Arg Val Arg 
                485                 490                 495     


Ala Gln Arg Leu Pro Glu Val Gln Val Leu Asn Val Ser Gly Arg Gly 
            500                 505                 510         


Asn Phe Phe Leu Thr Trp Asp Asn Val Ser Ser Gln Pro Ile Pro Ala 
        515                 520                 525             


Asn Ala Thr Ala His Leu Ile Gln Thr Thr Ile Glu Glu Leu Leu Ala 
    530                 535                 540                 


Val Lys Cys Lys Leu Glu Pro Leu Trp Ser Asn Ile Leu Leu Arg Leu 
545                 550                 555                 560 


Gly Phe Glu Arg Gly Pro Glu Val Ser Asn Ser Asp Gly Asp Leu Thr 
                565                 570                 575     


Ser Gly Thr Glu Pro Phe Cys Gly Arg Phe Ser Leu Arg Gln Pro Arg 
            580                 585                 590         


His Leu Val Leu Thr Pro Pro Ala Ala Gln Lys Gly Tyr Arg Leu Asp 
        595                 600                 605             


Gln Tyr Thr His Leu Cys Leu Ala Tyr Lys Gly His Met Asn Lys Ile 
    610                 615                 620                 


Leu Lys Met Ile Val Ser Phe Thr Ile Gly Phe Gln Asn Met Val Lys 
625                 630                 635                 640 


Asn Thr Thr Cys Asp Trp Ser Leu Thr Arg Thr Ser Pro Glu Ser Trp 
                645                 650                 655     


Gln Phe Asp Cys Thr Asp Leu Trp Glu Thr Cys Val Arg Cys Phe Gly 
            660                 665                 670         


Asp Leu Gln Pro Pro Pro Ala Asn Ser Pro Val Leu Val His Gln Ile 
        675                 680                 685             


Asn Leu Leu Pro Leu Ala Gln Glu Thr Gly Leu Phe Tyr Val Asp Glu 
    690                 695                 700                 


Ile Ile Ile Ala Asp Thr Asn Val Thr Val Ser Gln Ala Asp Ser Gly 
705                 710                 715                 720 


Thr Ala Arg Pro Gly Gly Asn Leu Val Glu Ser Val Ser Val Val Gly 
                725                 730                 735     


Ser Pro Pro Val Tyr Ser Val Thr Ser Trp Leu Ala Gly Cys Gly Thr 
            740                 745                 750         


Glu Leu Pro Leu Ile Thr Ala Arg Ser Val Pro Thr Glu Gly Thr Glu 
        755                 760                 765             


Glu Gly Ser Gly Leu Val Leu Val Thr Thr Gln Arg Arg Gln Arg Thr 
    770                 775                 780                 


Ser Pro Pro Leu Gly Gly His Phe Arg Ile Gln Leu Pro Asn Thr Val 
785                 790                 795                 800 


Ile Ser Asp Val Pro Val Gln Ile Ser Ala His His Leu His Gln Leu 
                805                 810                 815     


Leu Gln Asn Asn Ala Asp Asp Phe Thr Ser Arg Tyr Leu Asn Ala Ser 
            820                 825                 830         


Asp Phe Thr Val Lys Glu Asp Leu Tyr Thr Cys Tyr Glu His Val Trp 
        835                 840                 845             


Thr Leu Ser Trp Ser Thr Gln Ile Gly Asp Leu Pro Asn Phe Ile Arg 
    850                 855                 860                 


Val Ser Asp Glu Asn Leu Thr Gly Val Asn Pro Ala Ala Ala Thr Arg 
865                 870                 875                 880 


Val Val Tyr Asp Gly Gly Val Phe Leu Gly Pro Ile Phe Gly Asp Met 
                885                 890                 895     


Leu Ala Thr Ala Asn Gln His Thr Gln Val Val Val Arg Val Asn Asp 
            900                 905                 910         


Val Pro Ala His Cys Pro Gly Ser Cys Ser Phe Gln Tyr Leu Gln Gly 
        915                 920                 925             


Ser Thr Pro Cys Val His Ser Val Trp Tyr Ser Ile Asp Gly Asp Ile 
    930                 935                 940                 


Asn Leu Met Ile Tyr Ile Thr Gly Thr Gly Phe Ser Gly Asp Ser Gln 
945                 950                 955                 960 


Phe Leu Gln Val Thr Val Asn Lys Thr Ser Cys Lys Val Ile Phe Ser 
                965                 970                 975     


Asn Gln Thr Asn Val Val Cys Gln Thr Asp Leu Leu Pro Val Gly Met 
            980                 985                 990         


His Arg Ile Leu Met Leu Val Arg  Pro Ser Gly Leu Ala  Ile Ser Ala 
        995                 1000                 1005             


Thr Gly  Glu Asp Leu Phe Leu  Asn Val Lys Pro Arg  Leu Asp Met 
    1010                 1015                 1020             


Val Glu  Pro Ser Arg Ala Ala  Asp Ile Gly Gly Leu  Trp Ala Thr 
    1025                 1030                 1035             


Ile Arg  Gly Ser Ser Leu Glu  Gly Val Ser Leu Ile  Leu Phe Gly 
    1040                 1045                 1050             


Ser Tyr  Ser Cys Ala Ile Asn  Val Ala Thr Ser Asn  Ser Ser Arg 
    1055                 1060                 1065             


Ile Gln  Cys Lys Val Pro Pro  Arg Gly Lys Asp Gly  Arg Ile Val 
    1070                 1075                 1080             


Asn Val  Thr Val Ile Arg Gly  Asp Tyr Ser Ala Val  Leu Pro Arg 
    1085                 1090                 1095             


Ala Phe  Thr Tyr Val Ser Ser  Leu Asn Pro Val Ile  Val Thr Leu 
    1100                 1105                 1110             


Ser Arg  Asn Ile Ser Asn Ile  Ala Gly Gly Glu Thr  Leu Val Ile 
    1115                 1120                 1125             


Gly Val  Ala Arg Leu Met Asn  Tyr Thr Asp Leu Asp  Val Glu Val 
    1130                 1135                 1140             


His Val  Gln Asp Ala Leu Ala  Pro Val His Thr Gln  Ser Ala Trp 
    1145                 1150                 1155             


Gly Leu  Glu Val Ala Leu Pro  Pro Leu Pro Ala Gly  Leu His Arg 
    1160                 1165                 1170             


Ile Ser  Val Ser Ile Asn Gly  Val Ser Ile His Ser  Gln Gly Val 
    1175                 1180                 1185             


Asp Leu  His Ile Gln Tyr Leu  Thr Glu Val Phe Ser  Ile Glu Pro 
    1190                 1195                 1200             


Cys Cys  Gly Ser Leu Leu Gly  Gly Thr Ile Leu Ser  Ile Ser Gly 
    1205                 1210                 1215             


Ile Gly  Phe Ser Arg Asp Pro  Ala Leu Val Trp Val  Leu Val Gly 
    1220                 1225                 1230             


Asn Arg  Ser Cys Asp Ile Val  Asn Leu Thr Glu Ala  Ser Ile Trp 
    1235                 1240                 1245             


Cys Glu  Thr Leu Pro Ala Pro  Gln Ile Pro Asp Ala  Gly Ala Pro 
    1250                 1255                 1260             


Thr Val  Pro Ala Ala Val Glu  Val Trp Ala Gly Asn  Arg Phe Phe 
    1265                 1270                 1275             


Ala Arg  Gly Pro Ser Pro Ser  Leu Val Gly Lys Gly  Phe Thr Phe 
    1280                 1285                 1290             


Met Tyr  Glu Ala Ala Ala Thr  Pro Val Val Thr Ala  Met Gln Gly 
    1295                 1300                 1305             


Glu Ile  Thr Asn Ser Ser Leu  Ser Leu His Val Gly  Gly Ser Asn 
    1310                 1315                 1320             


Leu Ser  Asn Ser Val Ile Leu  Leu Gly Asn Leu Asn  Cys Asp Val 
    1325                 1330                 1335             


Glu Thr  Gln Ser Phe Gln Gly  Asn Val Ser Leu Ser  Gly Cys Ser 
    1340                 1345                 1350             


Ile Pro  Leu His Ser Leu Glu  Ala Gly Ile Tyr Pro  Leu Gln Val 
    1355                 1360                 1365             


Arg Gln  Lys Gln Met Gly Phe  Ala Asn Met Ser Val  Val Leu Gln 
    1370                 1375                 1380             


Gln Phe  Ala Val Met Pro Arg  Ile Met Ala Ile Phe  Pro Ser Gln 
    1385                 1390                 1395             


Gly Ser  Ala Cys Gly Gly Thr  Ile Leu Thr Val Arg  Gly Leu Leu 
    1400                 1405                 1410             


Leu Asn  Ser Arg Arg Arg Ser  Val Arg Val Asp Leu  Ser Gly Pro 
    1415                 1420                 1425             


Phe Thr  Cys Val Ile Leu Ser  Leu Gly Asp His Thr  Ile Leu Cys 
    1430                 1435                 1440             


Gln Val  Ser Leu Glu Gly Asp  Pro Leu Pro Gly Ala  Ser Phe Ser 
    1445                 1450                 1455             


Leu Asn  Val Thr Val Leu Val  Asn Gly Leu Thr Ser  Glu Cys Gln 
    1460                 1465                 1470             


Gly Asn  Cys Thr Leu Phe Ile  Arg Glu Glu Ala Ser  Pro Val Met 
    1475                 1480                 1485             


Asp Ala  Leu Ser Thr Asn Thr  Ser Gly Ser Leu Thr  Thr Val Leu 
    1490                 1495                 1500             


Ile Arg  Gly Gln Arg Leu Ala  Thr Thr Ala Asp Glu  Pro Met Val 
    1505                 1510                 1515             


Phe Val  Asp Asp Gln Leu Pro  Cys Asn Val Thr Phe  Phe Asn Ala 
    1520                 1525                 1530             


Ser His  Val Val Cys Gln Thr  Arg Asp Leu Ala Pro  Gly Pro His 
    1535                 1540                 1545             


Tyr Leu  Ser Val Phe Tyr Thr  Arg Asn Gly Tyr Ala  Cys Ser Gly 
    1550                 1555                 1560             


Asn Val  Ser Arg His Phe Tyr  Ile Met Pro Gln Val  Phe His Tyr 
    1565                 1570                 1575             


Phe Pro  Lys Asn Phe Ser Leu  His Gly Gly Ser Leu  Leu Thr Ile 
    1580                 1585                 1590             


Glu Gly  Thr Gly Leu Arg Gly  Gln Asn Thr Thr Ser  Val Tyr Ile 
    1595                 1600                 1605             


Asp Gln  Gln Thr Cys Leu Thr  Val Asn Ile Gly Ala  Glu Leu Ile 
    1610                 1615                 1620             


Arg Cys  Ile Val Pro Thr Gly  Asn Gly Ser Val Ala  Leu Glu Ile 
    1625                 1630                 1635             


Glu Val  Asp Gly Leu Trp Tyr  His Ile Gly Val Ile  Gly Tyr Asn 
    1640                 1645                 1650             


Lys Ala  Phe Thr Pro Glu Leu  Ile Ser Ile Ser Gln  Ser Asp Asp 
    1655                 1660                 1665             


Ile Leu  Thr Phe Ala Val Ala  Gln Ile Ser Gly Ala  Ala Asn Ile 
    1670                 1675                 1680             


Asp Ile  Phe Ile Gly Met Ser  Pro Cys Val Gly Val  Ser Gly Asn 
    1685                 1690                 1695             


His Thr  Val Leu Gln Cys Val  Val Pro Ser Leu Pro  Ala Gly Glu 
    1700                 1705                 1710             


Tyr His  Val Arg Gly Tyr Asp  Cys Ile Arg Gly Trp  Ala Ser Ser 
    1715                 1720                 1725             


Ala Leu  Val Phe Thr Ser Arg  Val Ile Ile Thr Ala  Val Thr Glu 
    1730                 1735                 1740             


Asn Phe  Gly Cys Leu Gly Gly  Arg Leu Val His Val  Phe Gly Ala 
    1745                 1750                 1755             


Gly Phe  Ser Pro Gly Asn Val  Ser Ala Ala Val Cys  Gly Ala Pro 
    1760                 1765                 1770             


Cys Arg  Val Leu Ala Asn Ala  Thr Val Ser Ala Phe  Ser Cys Leu 
    1775                 1780                 1785             


Val Leu  Pro Leu Asp Val Ser  Leu Ala Phe Leu Cys  Gly Leu Lys 
    1790                 1795                 1800             


Arg Glu  Glu Asp Ser Cys Glu  Ala Ala Arg His Thr  Tyr Val Gln 
    1805                 1810                 1815             


Cys Asp  Leu Thr Val Ala Met  Ala Thr Glu Gln Leu  Leu Glu Ser 
    1820                 1825                 1830             


Trp Pro  Tyr Leu Tyr Ile Cys  Glu Glu Ser Ser Gln  Cys Leu Phe 
    1835                 1840                 1845             


Val Pro  Asp His Trp Ala Glu  Ser Met Phe Pro Ser  Phe Ser Gly 
    1850                 1855                 1860             


Leu Phe  Ile Ser Pro Lys Leu  Glu Arg Asp Glu Val  Leu Ile Tyr 
    1865                 1870                 1875             


Asn Ser  Ser Cys Asn Ile Thr  Met Glu Thr Glu Ala  Glu Met Glu 
    1880                 1885                 1890             


Cys Glu  Thr Pro Asn Gln Pro  Ile Thr Val Lys Ile  Thr Glu Ile 
    1895                 1900                 1905             


Arg Lys  Arg Trp Gly Gln Asn  Thr Gln Gly Asn Phe  Ser Leu Gln 
    1910                 1915                 1920             


Phe Cys  Arg Arg Trp Ser Arg  Thr His Ser Trp Phe  Pro Glu Arg 
    1925                 1930                 1935             


Leu Pro  Gln Asp Gly Asp Asn  Val Thr Val Glu Asn  Gly Gln Leu 
    1940                 1945                 1950             


Leu Leu  Leu Asp Thr Asn Thr  Ser Ile Leu Asn Leu  Leu His Ile 
    1955                 1960                 1965             


Lys Gly  Gly Lys Leu Ile Phe  Met Ala Pro Gly Pro  Ile Glu Leu 
    1970                 1975                 1980             


Arg Ala  His Ala Ile Leu Val  Ser Asp Gly Gly Glu  Leu Arg Ile 
    1985                 1990                 1995             


Gly Ser  Glu Asp Lys Pro Phe  Gln Gly Arg Ala Gln  Ile Thr Leu 
    2000                 2005                 2010             


Tyr Gly  Ser Ser Tyr Ser Thr  Pro Phe Phe Pro Tyr  Gly Val Lys 
    2015                 2020                 2025             


Phe Leu  Ala Val Arg Asn Gly  Thr Leu Ser Leu His  Gly Ser Leu 
    2030                 2035                 2040             


Pro Glu  Val Ile Val Thr Cys  Leu Arg Ala Thr Ala  His Ala Leu 
    2045                 2050                 2055             


Asp Thr  Val Leu Ala Leu Glu  Asp Ala Val Asp Trp  Asn Pro Gly 
    2060                 2065                 2070             


Asp Glu  Val Val Ile Ile Ser  Gly Thr Gly Val Lys  Gly Ala Lys 
    2075                 2080                 2085             


Pro Met  Glu Glu Ile Val Thr  Val Glu Thr Val Gln  Asp Thr Asp 
    2090                 2095                 2100             


Leu Tyr  Leu Lys Ser Pro Leu  Arg Tyr Ser His Asn  Phe Thr Glu 
    2105                 2110                 2115             


Asn Trp  Val Ala Gly Glu His  His Ile Leu Lys Ala  Thr Val Ala 
    2120                 2125                 2130             


Leu Leu  Ser Arg Ser Ile Thr  Ile Gln Gly Asn Leu  Thr Asn Glu 
    2135                 2140                 2145             


Arg Glu  Lys Leu Leu Val Ser  Cys Gln Glu Ala Asn  Ala Pro Glu 
    2150                 2155                 2160             


Gly Asn  Leu Gln His Cys Leu  Tyr Ser Met Ser Glu  Lys Met Leu 
    2165                 2170                 2175             


Gly Ser  Arg Asp Met Gly Ala  Arg Val Ile Val Gln  Ser Phe Pro 
    2180                 2185                 2190             


Glu Glu  Pro Ser Gln Val Gln  Leu Lys Gly Val Gln  Phe Gln Val 
    2195                 2200                 2205             


Leu Gly  Gln Ala Phe His Lys  His Leu Ser Ser Leu  Thr Leu Val 
    2210                 2215                 2220             


Gly Ala  Met Arg Glu Ser Phe  Ile Gln Gly Cys Thr  Val Arg Asn 
    2225                 2230                 2235             


Ser Phe  Ser Arg Gly Leu Ser  Met Cys Gly Thr Leu  Gly Leu Lys 
    2240                 2245                 2250             


Val Asp  Ser Asn Val Phe Tyr  Asn Ile Leu Gly His  Ala Leu Leu 
    2255                 2260                 2265             


Val Gly  Thr Cys Thr Glu Met  Arg Tyr Ile Ser Trp  Glu Ala Ile 
    2270                 2275                 2280             


His Gly  Arg Lys Asp Asp Trp  Ser Gly His Gly Asn  Ile Ile Arg 
    2285                 2290                 2295             


Asn Asn  Val Ile Ile Gln Val  Ser Gly Ala Glu Gly  Leu Ser Asn 
    2300                 2305                 2310             


Pro Glu  Met Leu Thr Pro Ser  Gly Ile Tyr Ile Cys  Ser Pro Thr 
    2315                 2320                 2325             


Asn Val  Ile Glu Gly Asn Arg  Val Cys Gly Ala Gly  Tyr Gly Tyr 
    2330                 2335                 2340             


Phe Phe  His Leu Met Thr Asn  Gln Thr Ser Gln Ala  Pro Leu Leu 
    2345                 2350                 2355             


Ser Phe  Thr Gln Asn Ile Ala  His Ser Cys Thr Arg  Tyr Gly Leu 
    2360                 2365                 2370             


Phe Val  Tyr Pro Lys Phe Gln  Pro Pro Trp Asp Asn  Val Thr Gly 
    2375                 2380                 2385             


Thr Thr  Leu Phe Gln Ser Phe  Thr Val Trp Glu Ser  Ala Gly Gly 
    2390                 2395                 2400             


Ala Gln  Ile Phe Arg Ser Ser  Asn Leu Arg Leu Lys  Asn Phe Lys 
    2405                 2410                 2415             


Val Tyr  Ser Cys Arg Asp Phe  Gly Ile Asp Val Leu  Glu Ser Asp 
    2420                 2425                 2430             


Ala Asn  Thr Ser Val Thr Asp  Ser Leu Leu Leu Gly  His Phe Ala 
    2435                 2440                 2445             


His Lys  Gly Ser Leu Cys Met  Ser Ser Gly Ile Lys  Thr Pro Lys 
    2450                 2455                 2460             


Arg Trp  Glu Leu Met Val Ser  Asn Thr Thr Phe Val  Asn Phe Asp 
    2465                 2470                 2475             


Leu Ile  Asn Cys Val Ala Ile  Arg Thr Cys Ser Asp  Cys Ser Gln 
    2480                 2485                 2490             


Gly Gln  Gly Gly Phe Thr Val  Lys Thr Ser Gln Leu  Lys Phe Thr 
    2495                 2500                 2505             


Asn Ser  Ser Asn Leu Val Ala  Phe Pro Phe Pro His  Ala Ala Ile 
    2510                 2515                 2520             


Leu Glu  Asp Leu Asp Gly Ser  Leu Ser Gly Lys Asn  Arg Ser His 
    2525                 2530                 2535             


Ile Leu  Ala Ser Met Glu Thr  Leu Ser Ala Ser Cys  Leu Val Asn 
    2540                 2545                 2550             


Ser Ser  Phe Gly Arg Val Val  His Gly Ser Ala Cys  Gly Gly Gly 
    2555                 2560                 2565             


Val Leu  Phe His Arg Met Ser  Ile Gly Leu Ala Asn  Thr Pro Glu 
    2570                 2575                 2580             


Val Ser  Tyr Asp Leu Thr Met  Thr Asp Ser Arg Asn  Lys Thr Thr 
    2585                 2590                 2595             


Thr Val  Asn Tyr Val Arg Asp  Thr Leu Ser Asn Pro  Arg Gly Trp 
    2600                 2605                 2610             


Met Ala  Leu Leu Leu Asp Gln  Glu Thr Tyr Ser Leu  Gln Ser Glu 
    2615                 2620                 2625             


Asn Leu  Trp Ile Asn Arg Ser  Leu Gln Tyr Ser Ala  Thr Phe Asp 
    2630                 2635                 2640             


Asn Phe  Ala Pro Gly Asn Tyr  Leu Leu Leu Val His  Thr Asp Leu 
    2645                 2650                 2655             


Pro Pro  Tyr Pro Asp Ile Leu  Leu Arg Cys Gly Ser  Arg Val Gly 
    2660                 2665                 2670             


Leu Ser  Phe Pro Phe Leu Pro  Ser Pro Gly Gln Asn  Gln Gly Cys 
    2675                 2680                 2685             


Asp Trp  Phe Phe Asn Ser Gln  Leu Arg Gln Leu Thr  Tyr Leu Val 
    2690                 2695                 2700             


Ser Gly  Glu Gly Gln Val Gln  Val Ile Leu Arg Val  Lys Glu Gly 
    2705                 2710                 2715             


Met Pro  Pro Thr Ile Ser Ala  Ser Thr Ser Ala Pro  Glu Ser Ala 
    2720                 2725                 2730             


Leu Lys  Trp Ser Leu Pro Glu  Thr Trp Gln Gly Val  Glu Glu Gly 
    2735                 2740                 2745             


Trp Gly  Gly Tyr Asn Asn Thr  Ile Pro Gly Pro Gly  Asp Asp Val 
    2750                 2755                 2760             


Leu Ile  Leu Pro Asn Arg Thr  Val Leu Val Asp Thr  Asp Leu Pro 
    2765                 2770                 2775             


Phe Phe  Lys Gly Leu Tyr Val  Met Gly Thr Leu Asp  Phe Pro Val 
    2780                 2785                 2790             


Asp Arg  Ser Asn Val Leu Ser  Val Ala Cys Met Val  Ile Ala Gly 
    2795                 2800                 2805             


Gly Glu  Leu Lys Val Gly Thr  Leu Glu Asn Pro Leu  Glu Lys Glu 
    2810                 2815                 2820             


Gln Lys  Leu Leu Ile Leu Leu  Arg Ala Ser Glu Gly  Val Phe Cys 
    2825                 2830                 2835             


Asp Arg  Met Asn Gly Ile His  Ile Asp Pro Gly Thr  Ile Gly Val 
    2840                 2845                 2850             


Tyr Gly  Lys Val His Leu Tyr  Ser Ala Tyr Pro Lys  Asn Ser Trp 
    2855                 2860                 2865             


Thr His  Leu Gly Ala Asp Ile  Ala Ser Gly Asn Glu  Arg Ile Ile 
    2870                 2875                 2880             


Val Glu  Asp Ala Val Asp Trp  Arg Pro His Asp Lys  Ile Val Leu 
    2885                 2890                 2895             


Ser Ser  Ser Ser Tyr Glu Pro  His Glu Ala Glu Val  Leu Thr Val 
    2900                 2905                 2910             


Lys Glu  Val Lys Gly His His  Val Arg Ile Tyr Glu  Arg Leu Lys 
    2915                 2920                 2925             


His Arg  His Ile Gly Ser Val  His Val Thr Glu Asp  Gly Arg His 
    2930                 2935                 2940             


Ile Arg  Leu Ala Ala Glu Val  Gly Leu Leu Thr Arg  Asn Ile Gln 
    2945                 2950                 2955             


Ile Gln  Pro Asp Val Ser Cys  Arg Gly Arg Leu Phe  Val Gly Ser 
    2960                 2965                 2970             


Phe Arg  Lys Ser Ser Arg Glu  Glu Phe Ser Gly Val  Leu Gln Leu 
    2975                 2980                 2985             


Leu Asn  Val Glu Ile Gln Asn  Phe Gly Ser Pro Leu  Tyr Ser Ser 
    2990                 2995                 3000             


Val Glu  Phe Ser Asn Val Ser  Ala Gly Ser Trp Ile  Ile Ser Ser 
    3005                 3010                 3015             


Thr Leu  His Gln Ser Cys Gly  Gly Gly Ile His Ala  Ala Ala Ser 
    3020                 3025                 3030             


His Gly  Val Leu Leu Asn Asp  Asn Ile Val Phe Gly  Thr Ala Gly 
    3035                 3040                 3045             


His Gly  Ile Asp Leu Glu Gly  Gln Ala Tyr Thr Val  Thr Asn Asn 
    3050                 3055                 3060             


Leu Val  Val Leu Met Thr Gln  Pro Ala Trp Ser Thr  Ile Trp Val 
    3065                 3070                 3075             


Ala Gly  Ile Lys Val Asn Gln  Val Lys Asp Ile Asn  Leu His Gly 
    3080                 3085                 3090             


Asn Val  Val Ala Gly Ser Glu  Arg Leu Gly Phe His  Ile Arg Gly 
    3095                 3100                 3105             


His Lys  Cys Ser Ser Cys Glu  Leu Leu Trp Ser Asp  Asn Val Ala 
    3110                 3115                 3120             


His Ser  Ser Leu His Gly Leu  His Leu Tyr Lys Glu  Ser Gly Leu 
    3125                 3130                 3135             


Asp Asn  Cys Thr Arg Ile Ser  Gly Phe Leu Ala Phe  Lys Asn Phe 
    3140                 3145                 3150             


Asp Tyr  Gly Ala Met Leu His  Val Glu Asn Ser Val  Glu Ile Glu 
    3155                 3160                 3165             


Asn Ile  Thr Leu Val Asp Asn  Thr Ile Gly Leu Leu  Ala Val Val 
    3170                 3175                 3180             


Tyr Val  Phe Ser Ala Pro Gln  Asn Ser Val Lys Lys  Val Gln Ile 
    3185                 3190                 3195             


Val Leu  Arg Asn Ser Val Ile  Val Ala Thr Ser Ser  Ser Phe Asp 
    3200                 3205                 3210             


Cys Ile  Gln Asp Lys Val Lys  Pro His Ser Ala Asn  Leu Thr Ser 
    3215                 3220                 3225             


Thr Asp  Arg Ala Pro Ser Asn  Pro Arg Gly Gly Arg  Ile Gly Ile 
    3230                 3235                 3240             


Leu Trp  Pro Val Phe Thr Ser  Glu Pro Asn Gln Trp  Pro Gln Glu 
    3245                 3250                 3255             


Pro Trp  His Lys Val Arg Asn  Asp His Ser Ile Ser  Gly Ile Met 
    3260                 3265                 3270             


Lys Leu  Gln Asp Val Thr Phe  Ser Ser Phe Val Lys  Ser Cys Tyr 
    3275                 3280                 3285             


Ser Asp  Asp Leu Asp Val Cys  Ile Leu Pro Asn Ala  Glu Asn Ser 
    3290                 3295                 3300             


Gly Ile  Met His Pro Ile Thr  Ala Glu Arg Thr Arg  Met Leu Lys 
    3305                 3310                 3315             


Ile Lys  Asp Lys Asn Lys Phe  Tyr Phe Pro Ser Leu  Gln Pro Arg 
    3320                 3325                 3330             


Lys Asp  Leu Gly Lys Val Val  Cys Pro Glu Leu Asp  Cys Ala Ser 
    3335                 3340                 3345             


Pro Arg  Lys Tyr Leu Phe Lys  Asp Leu Asp Gly Arg  Ala Leu Gly 
    3350                 3355                 3360             


Leu Pro  Pro Pro Val Ser Val  Phe Pro Lys Thr Glu  Ala Glu Trp 
    3365                 3370                 3375             


Thr Ala  Ser Phe Phe Asn Ala  Gly Thr Phe Arg Glu  Glu Gln Lys 
    3380                 3385                 3390             


Cys Thr  Tyr Gln Phe Leu Met  Gln Gly Phe Ile Cys  Lys Gln Thr 
    3395                 3400                 3405             


Asp Gln  Val Val Leu Ile Leu  Asp Ser Ala Asp Ala  Ile Trp Ala 
    3410                 3415                 3420             


Ile Gln  Lys Leu Tyr Pro Val  Val Ser Val Thr Ser  Gly Phe Val 
    3425                 3430                 3435             


Asp Val  Phe Ser Ser Val Asn  Ala Asn Ile Pro Cys  Ser Thr Ser 
    3440                 3445                 3450             


Gly Ser  Val Ser Thr Phe Tyr  Ser Ile Leu Pro Ile  Arg Gln Ile 
    3455                 3460                 3465             


Thr Lys  Val Cys Phe Met Asp  Gln Thr Pro Gln Val  Leu Arg Phe 
    3470                 3475                 3480             


Phe Leu  Leu Gly Asn Lys Ser  Thr Ser Lys Leu Leu  Leu Ala Val 
    3485                 3490                 3495             


Phe Tyr  His Glu Leu Gln Ser  Pro His Val Phe Leu  Gly Glu Ser 
    3500                 3505                 3510             


Phe Ile  Pro Pro Thr Leu Val  Gln Ser Ala Ser Leu  Leu Leu Asn 
    3515                 3520                 3525             


Glu Ser  Ile Gly Ala Asn Tyr  Phe Asn Ile Met Asp  Asn Leu Leu 
    3530                 3535                 3540             


Tyr Val  Val Leu Gln Gly Glu  Glu Pro Ile Glu Ile  Arg Ser Gly 
    3545                 3550                 3555             


Val Ser  Ile His Leu Ala Leu  Thr Val Met Val Ser  Val Leu Glu 
    3560                 3565                 3570             


Lys Gly  Trp Glu Ile Val Ile  Leu Glu Arg Leu Thr  Asn Phe Leu 
    3575                 3580                 3585             


Gln Ile  Gly Gln Asn Gln Ile  Arg Phe Ile His Glu  Met Pro Gly 
    3590                 3595                 3600             


His Glu  Glu Thr Leu Lys Ala  Ile Ala Asp Ser Arg  Ala Lys Arg 
    3605                 3610                 3615             


Lys Arg  Asn Cys Pro Thr Val  Thr Cys Thr Ser His  Tyr Arg Arg 
    3620                 3625                 3630             


Val Gly  Gln Arg Arg Pro Leu  Met Met Glu Met Asn  Ser His Arg 
    3635                 3640                 3645             


Ala Ser  Pro Pro Met Thr Val  Glu Thr Ile Ser Lys  Val Ile Val 
    3650                 3655                 3660             


Ile Glu  Ile Gly Asp Ser Pro  Thr Val Arg Ser Thr  Gly Met Ile 
    3665                 3670                 3675             


Ser Ser  Leu Ser Ser Asn Lys  Leu Gln Asn Leu Ala  His Arg Val 
    3680                 3685                 3690             


Ile Thr  Ala Gln Gln Thr Gly  Val Leu Glu Asn Val  Leu Asn Met 
    3695                 3700                 3705             


Thr Ile  Gly Ala Leu Leu Val  Thr Gln Ser Lys Gly  Val Ile Gly 
    3710                 3715                 3720             


Tyr Gly  Asn Thr Ser Ser Phe  Lys Thr Gly Asn Leu  Ile Tyr Ile 
    3725                 3730                 3735             


Arg Pro  Tyr Ala Leu Ser Ile  Leu Val Gln Pro Ser  Asp Gly Glu 
    3740                 3745                 3750             


Val Gly  Asn Glu Leu Pro Val  Gln Pro Gln Leu Val  Phe Leu Asp 
    3755                 3760                 3765             


Glu Gln  Asn Arg Arg Val Glu  Ser Leu Gly Pro Pro  Ser Glu Pro 
    3770                 3775                 3780             


Trp Thr  Ile Ser Ala Ser Leu  Glu Gly Ala Ser Asp  Ser Val Leu 
    3785                 3790                 3795             


Lys Gly  Cys Thr Gln Ala Glu  Thr Gln Asp Gly Tyr  Val Ser Phe 
    3800                 3805                 3810             


Tyr Asn  Leu Ala Val Leu Ile  Ser Gly Ser Asn Trp  His Phe Ile 
    3815                 3820                 3825             


Phe Thr  Val Thr Ser Pro Pro  Gly Val Asn Phe Thr  Ala Arg Ser 
    3830                 3835                 3840             


Lys Pro  Phe Ala Val Leu Pro  Val Thr Arg Lys Glu  Lys Ser Thr 
    3845                 3850                 3855             


Ile Ile  Leu Ala Ala Ser Leu  Ser Ser Val Ala Ser  Trp Leu Ala 
    3860                 3865                 3870             


Leu Ser  Cys Leu Val Cys Cys  Trp Leu Lys Arg Ser  Lys Ser Arg 
    3875                 3880                 3885             


Lys Thr  Lys Pro Glu Glu Ile  Pro Glu Ser Gln Thr  Asn Asn Gln 
    3890                 3895                 3900             


Asn Ile  His Ile His Ile Ser  Ser Lys Arg Arg Glu  Ser Gln Gly 
    3905                 3910                 3915             


Pro Lys  Lys Glu Asp Thr Val  Val Gly Glu Asp Met  Arg Met Lys 
    3920                 3925                 3930             


Val Met  Leu Gly Lys Val Asn  Gln Cys Pro His Gln  Leu Met Asn 
    3935                 3940                 3945             


Gly Val  Ser Arg Arg Lys Val  Ser Arg His Ile Val  Arg Glu Glu 
    3950                 3955                 3960             


Glu Ala  Ala Val Pro Ala Pro  Gly Thr Thr Gly Ile  Thr Ser His 
    3965                 3970                 3975             


Gly His  Ile Cys Ala Pro Gly  Ala Pro Ala Gln Gln  Val Tyr Leu 
    3980                 3985                 3990             


Gln Glu  Thr Gly Asn Trp Lys  Glu Gly Gln Glu Gln  Leu Leu Arg 
    3995                 4000                 4005             


Tyr Gln  Leu Ala Gly Gln Asn  Gln Leu Leu Leu Leu  Cys Pro Asp 
    4010                 4015                 4020             


Phe Arg  Gln Glu Arg Gln Gln  Leu Pro Gly Gln Ser  Arg Leu Ser 
    4025                 4030                 4035             


Lys Gln  Ser Gly Ser Leu Gly  Leu Ser Gln Glu Lys  Lys Ala Ser 
    4040                 4045                 4050             


Cys Gly  Ala Thr Glu Ala Phe  Cys Leu His Ser Val  His Pro Glu 
    4055                 4060                 4065             


Thr Ile  Gln Glu Gln Leu 
    4070                 


<210>  5772
<211>  841
<212>  PRT
<213>  Homo sapiens

<400>  5772

Met Leu Leu Cys Thr Ala Arg Leu Val Gly Leu Gln Leu Leu Ile Ser 
1               5                   10                  15      


Cys Cys Trp Ala Phe Ala Cys His Ser Thr Glu Ser Ser Pro Asp Phe 
            20                  25                  30          


Thr Leu Pro Gly Asp Tyr Leu Leu Ala Gly Leu Phe Pro Leu His Ser 
        35                  40                  45              


Gly Cys Leu Gln Val Arg His Arg Pro Glu Val Thr Leu Cys Asp Arg 
    50                  55                  60                  


Ser Cys Ser Phe Asn Glu His Gly Tyr His Leu Phe Gln Ala Met Arg 
65                  70                  75                  80  


Leu Gly Val Glu Glu Ile Asn Asn Ser Thr Ala Leu Leu Pro Asn Ile 
                85                  90                  95      


Thr Leu Gly Tyr Gln Leu Tyr Asp Val Cys Ser Asp Ser Ala Asn Val 
            100                 105                 110         


Tyr Ala Thr Leu Arg Val Leu Ser Leu Pro Gly Gln His His Ile Glu 
        115                 120                 125             


Leu Gln Gly Asp Leu Leu His Tyr Ser Pro Thr Val Leu Ala Val Ile 
    130                 135                 140                 


Gly Pro Asp Ser Thr Asn Arg Ala Ala Thr Thr Ala Ala Leu Leu Ser 
145                 150                 155                 160 


Pro Phe Leu Val Pro Met Ile Ser Tyr Ala Ala Ser Ser Glu Thr Leu 
                165                 170                 175     


Ser Val Lys Arg Gln Tyr Pro Ser Phe Leu Arg Thr Ile Pro Asn Asp 
            180                 185                 190         


Lys Tyr Gln Val Glu Thr Met Val Leu Leu Leu Gln Lys Phe Gly Trp 
        195                 200                 205             


Thr Trp Ile Ser Leu Val Gly Ser Ser Asp Asp Tyr Gly Gln Leu Gly 
    210                 215                 220                 


Val Gln Ala Leu Glu Asn Gln Ala Thr Gly Gln Gly Ile Cys Ile Ala 
225                 230                 235                 240 


Phe Lys Asp Ile Met Pro Phe Ser Ala Gln Val Gly Asp Glu Arg Met 
                245                 250                 255     


Gln Cys Leu Met Arg His Leu Ala Gln Ala Gly Ala Thr Val Val Val 
            260                 265                 270         


Val Phe Ser Ser Arg Gln Leu Ala Arg Val Phe Phe Glu Ser Val Val 
        275                 280                 285             


Leu Thr Asn Leu Thr Gly Lys Val Trp Val Ala Ser Glu Ala Trp Ala 
    290                 295                 300                 


Leu Ser Arg His Ile Thr Gly Val Pro Gly Ile Gln Arg Ile Gly Met 
305                 310                 315                 320 


Val Leu Gly Val Ala Ile Gln Lys Arg Ala Val Pro Gly Leu Lys Ala 
                325                 330                 335     


Phe Glu Glu Ala Tyr Ala Arg Ala Asp Lys Lys Ala Pro Arg Pro Cys 
            340                 345                 350         


His Lys Gly Ser Trp Cys Ser Ser Asn Gln Leu Cys Arg Glu Cys Gln 
        355                 360                 365             


Ala Phe Met Ala His Thr Met Pro Lys Leu Lys Ala Phe Ser Met Ser 
    370                 375                 380                 


Ser Ala Tyr Asn Ala Tyr Arg Ala Val Tyr Ala Val Ala His Gly Leu 
385                 390                 395                 400 


His Gln Leu Leu Gly Cys Ala Ser Gly Ala Cys Ser Arg Gly Arg Val 
                405                 410                 415     


Tyr Pro Trp Gln Leu Leu Glu Gln Ile His Lys Val His Phe Leu Leu 
            420                 425                 430         


His Lys Asp Thr Val Ala Phe Asn Asp Asn Arg Asp Pro Leu Ser Ser 
        435                 440                 445             


Tyr Asn Ile Ile Ala Trp Asp Trp Asn Gly Pro Lys Trp Thr Phe Thr 
    450                 455                 460                 


Val Leu Gly Ser Ser Thr Trp Ser Pro Val Gln Leu Asn Ile Asn Glu 
465                 470                 475                 480 


Thr Lys Ile Gln Trp His Gly Lys Asp Asn Gln Val Pro Lys Ser Val 
                485                 490                 495     


Cys Ser Ser Asp Cys Leu Glu Gly His Gln Arg Val Val Thr Gly Phe 
            500                 505                 510         


His His Cys Cys Phe Glu Cys Val Pro Cys Gly Ala Gly Thr Phe Leu 
        515                 520                 525             


Asn Lys Ser Asp Leu Tyr Arg Cys Gln Pro Cys Gly Lys Glu Glu Trp 
    530                 535                 540                 


Ala Pro Glu Gly Ser Gln Thr Cys Phe Pro Arg Thr Val Val Phe Leu 
545                 550                 555                 560 


Ala Leu Arg Glu His Thr Ser Trp Val Leu Leu Ala Ala Asn Thr Leu 
                565                 570                 575     


Leu Leu Leu Leu Leu Leu Gly Thr Ala Gly Leu Phe Ala Trp His Leu 
            580                 585                 590         


Asp Thr Pro Val Val Arg Ser Ala Gly Gly Arg Leu Cys Phe Leu Met 
        595                 600                 605             


Leu Gly Ser Leu Ala Ala Gly Ser Gly Ser Leu Tyr Gly Phe Phe Gly 
    610                 615                 620                 


Glu Pro Thr Arg Pro Ala Cys Leu Leu Arg Gln Ala Leu Phe Ala Leu 
625                 630                 635                 640 


Gly Phe Thr Ile Phe Leu Ser Cys Leu Thr Val Arg Ser Phe Gln Leu 
                645                 650                 655     


Ile Ile Ile Phe Lys Phe Ser Thr Lys Val Pro Thr Phe Tyr His Ala 
            660                 665                 670         


Trp Val Gln Asn His Gly Ala Gly Leu Phe Val Met Ile Ser Ser Ala 
        675                 680                 685             


Ala Gln Leu Leu Ile Cys Leu Thr Trp Leu Val Val Trp Thr Pro Leu 
    690                 695                 700                 


Pro Ala Arg Glu Tyr Gln Arg Phe Pro His Leu Val Met Leu Glu Cys 
705                 710                 715                 720 


Thr Glu Thr Asn Ser Leu Gly Phe Ile Leu Ala Phe Leu Tyr Asn Gly 
                725                 730                 735     


Leu Leu Ser Ile Ser Ala Phe Ala Cys Ser Tyr Leu Gly Lys Asp Leu 
            740                 745                 750         


Pro Glu Asn Tyr Asn Glu Ala Lys Cys Val Thr Phe Ser Leu Leu Phe 
        755                 760                 765             


Asn Phe Val Ser Trp Ile Ala Phe Phe Thr Thr Ala Ser Val Tyr Asp 
    770                 775                 780                 


Gly Lys Tyr Leu Pro Ala Ala Asn Met Met Ala Gly Leu Ser Ser Leu 
785                 790                 795                 800 


Ser Ser Gly Phe Gly Gly Tyr Phe Leu Pro Lys Cys Tyr Val Ile Leu 
                805                 810                 815     


Cys Arg Pro Asp Leu Asn Ser Thr Glu His Phe Gln Ala Ser Ile Gln 
            820                 825                 830         


Asp Tyr Thr Arg Arg Cys Gly Ser Thr 
        835                 840     


<210>  5773
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  5773

Met Ala Phe Pro Cys Arg Arg Ser Leu Thr Ala Lys Thr Leu Ala Cys 
1               5                   10                  15      


Leu Leu Val Gly Val Ser Phe Leu Ala Leu Gln Gln Trp Phe Leu Gln 
            20                  25                  30          


Ala Pro Arg Ser Pro Arg Glu Glu Arg Ser Pro Gln Glu Glu Thr Pro 
        35                  40                  45              


Glu Gly Pro Thr Asp Ala Pro Ala Ala Asp Glu Pro Pro Ser Glu Leu 
    50                  55                  60                  


Val Pro Gly Pro Pro Cys Val Ala Asn Ala Ser Ala Asn Ala Thr Ala 
65                  70                  75                  80  


Asp Phe Glu Gln Leu Pro Ala Arg Ile Gln Asp Phe Leu Arg Tyr Arg 
                85                  90                  95      


His Cys Arg His Phe Pro Leu Leu Trp Asp Ala Pro Ala Lys Cys Ala 
            100                 105                 110         


Gly Gly Arg Gly Val Phe Leu Leu Leu Ala Val Lys Ser Ala Pro Glu 
        115                 120                 125             


His Tyr Glu Arg Arg Glu Leu Ile Arg Arg Thr Trp Gly Gln Glu Arg 
    130                 135                 140                 


Ser Tyr Gly Gly Arg Pro Val Arg Arg Leu Phe Leu Leu Gly Thr Pro 
145                 150                 155                 160 


Gly Pro Glu Asp Glu Ala Arg Ala Glu Arg Leu Ala Glu Leu Val Ala 
                165                 170                 175     


Leu Glu Ala Arg Glu His Gly Asp Val Leu Gln Trp Ala Phe Ala Asp 
            180                 185                 190         


Thr Phe Leu Asn Leu Thr Leu Lys His Leu His Leu Leu Asp Trp Leu 
        195                 200                 205             


Ala Ala Arg Cys Pro His Ala Arg Phe Leu Leu Ser Gly Asp Asp Asp 
    210                 215                 220                 


Val Phe Val His Thr Ala Asn Val Val Arg Phe Leu Gln Ala Gln Pro 
225                 230                 235                 240 


Pro Gly Arg His Leu Phe Ser Gly Gln Leu Met Glu Gly Ser Val Pro 
                245                 250                 255     


Ile Arg Asp Ser Trp Ser Lys Tyr Phe Val Pro Pro Gln Leu Phe Pro 
            260                 265                 270         


Gly Ser Ala Tyr Pro Val Tyr Cys Ser Gly Gly Gly Phe Leu Leu Ser 
        275                 280                 285             


Gly Pro Thr Ala Arg Ala Leu Arg Ala Ala Ala Arg His Thr Pro Leu 
    290                 295                 300                 


Phe Pro Ile Asp Asp Ala Tyr Met Gly Met Cys Leu Glu Arg Ala Gly 
305                 310                 315                 320 


Leu Ala Pro Ser Gly His Glu Gly Ile Arg Pro Phe Gly Val Gln Leu 
                325                 330                 335     


Pro Gly Ala Gln Gln Ser Ser Phe Asp Pro Cys Met Tyr Arg Glu Leu 
            340                 345                 350         


Leu Leu Val His Arg Phe Ala Pro Tyr Glu Met Leu Leu Met Trp Lys 
        355                 360                 365             


Ala Leu His Ser Pro Ala Leu Ser Cys Asp Arg Gly His Arg Val Ser 
    370                 375                 380                 


<210>  5774
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  5774

Met Glu Gln Trp Asp His Phe His Asn Gln Gln Glu Asp Thr Asp Ser 
1               5                   10                  15      


Cys Ser Glu Ser Val Lys Phe Asp Ala Arg Ser Met Thr Ala Leu Leu 
            20                  25                  30          


Pro Pro Asn Pro Lys Asn Ser Pro Ser Leu Gln Glu Lys Leu Lys Ser 
        35                  40                  45              


Phe Lys Ala Ala Leu Ile Ala Leu Tyr Leu Leu Val Phe Ala Val Leu 
    50                  55                  60                  


Ile Pro Leu Ile Gly Ile Val Ala Ala Gln Leu Leu Lys Trp Glu Thr 
65                  70                  75                  80  


Lys Asn Cys Ser Val Ser Ser Thr Asn Ala Asn Asp Ile Thr Gln Ser 
                85                  90                  95      


Leu Thr Gly Lys Gly Asn Asp Ser Glu Glu Glu Met Arg Phe Gln Glu 
            100                 105                 110         


Val Phe Met Glu His Met Ser Asn Met Glu Lys Arg Ile Gln His Ile 
        115                 120                 125             


Leu Asp Met Glu Ala Asn Leu Met Asp Thr Glu His Phe Gln Asn Phe 
    130                 135                 140                 


Ser Met Thr Thr Asp Gln Arg Phe Asn Asp Ile Leu Leu Gln Leu Ser 
145                 150                 155                 160 


Thr Leu Phe Ser Ser Val Gln Gly His Gly Asn Ala Ile Asp Glu Ile 
                165                 170                 175     


Ser Lys Ser Leu Ile Ser Leu Asn Thr Thr Leu Leu Asp Leu Gln Leu 
            180                 185                 190         


Asn Ile Glu Asn Leu Asn Gly Lys Ile Gln Glu Asn Thr Phe Lys Gln 
        195                 200                 205             


Gln Glu Glu Ile Ser Lys Leu Glu Glu Arg Val Tyr Asn Val Ser Ala 
    210                 215                 220                 


Glu Ile Met Ala Met Lys Glu Glu Gln Val His Leu Glu Gln Glu Ile 
225                 230                 235                 240 


Lys Gly Glu Val Lys Val Leu Asn Asn Ile Thr Asn Asp Leu Arg Leu 
                245                 250                 255     


Lys Asp Trp Glu His Ser Gln Thr Leu Arg Asn Ile Thr Leu Ile Gln 
            260                 265                 270         


Gly Pro Pro Gly Pro Pro Gly Glu Lys Gly Asp Arg Gly Pro Thr Gly 
        275                 280                 285             


Glu Ser Gly Pro Arg Gly Phe Pro Gly Pro Ile Gly Pro Pro Gly Leu 
    290                 295                 300                 


Lys Gly Asp Arg Gly Ala Ile Gly Phe Pro Gly Ser Arg Gly Leu Pro 
305                 310                 315                 320 


Gly Tyr Ala Gly Arg Pro Gly Asn Ser Gly Pro Lys Gly Gln Lys Gly 
                325                 330                 335     


Glu Lys Gly Ser Gly Asn Thr Leu Thr Pro Phe Thr Lys Val Arg Leu 
            340                 345                 350         


Val Gly Gly Ser Gly Pro His Glu Gly Arg Val Glu Ile Leu His Ser 
        355                 360                 365             


Gly Gln Trp Gly Thr Ile Cys Asp Asp Arg Trp Glu Val Arg Val Gly 
    370                 375                 380                 


Gln Val Val Cys Arg Ser Leu Gly Tyr Pro Gly Val Gln Ala Val His 
385                 390                 395                 400 


Lys Ala Ala His Phe Gly Gln Gly Thr Gly Pro Ile Trp Leu Asn Glu 
                405                 410                 415     


Val Phe Cys Phe Gly Arg Glu Ser Ser Ile Glu Glu Cys Lys Ile Arg 
            420                 425                 430         


Gln Trp Gly Thr Arg Ala Cys Ser His Ser Glu Asp Ala Gly Val Thr 
        435                 440                 445             


Cys Thr Leu 
    450     


<210>  5775
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  5775

Met Glu Gln Trp Asp His Phe His Asn Gln Gln Glu Asp Thr Asp Ser 
1               5                   10                  15      


Cys Ser Glu Ser Val Lys Phe Asp Ala Arg Ser Met Thr Ala Leu Leu 
            20                  25                  30          


Pro Pro Asn Pro Lys Asn Ser Pro Ser Leu Gln Glu Lys Leu Lys Ser 
        35                  40                  45              


Phe Lys Ala Ala Leu Ile Ala Leu Tyr Leu Leu Val Phe Ala Val Leu 
    50                  55                  60                  


Ile Pro Leu Ile Gly Ile Val Ala Ala Gln Leu Leu Lys Trp Glu Thr 
65                  70                  75                  80  


Lys Asn Cys Ser Val Ser Ser Thr Asn Ala Asn Asp Ile Thr Gln Ser 
                85                  90                  95      


Leu Thr Gly Lys Gly Asn Asp Ser Glu Glu Glu Met Arg Phe Gln Glu 
            100                 105                 110         


Val Phe Met Glu His Met Ser Asn Met Glu Lys Arg Ile Gln His Ile 
        115                 120                 125             


Leu Asp Met Glu Ala Asn Leu Met Asp Thr Glu His Phe Gln Asn Phe 
    130                 135                 140                 


Ser Met Thr Thr Asp Gln Arg Phe Asn Asp Ile Leu Leu Gln Leu Ser 
145                 150                 155                 160 


Thr Leu Phe Ser Ser Val Gln Gly His Gly Asn Ala Ile Asp Glu Ile 
                165                 170                 175     


Ser Lys Ser Leu Ile Ser Leu Asn Thr Thr Leu Leu Asp Leu Gln Leu 
            180                 185                 190         


Asn Ile Glu Asn Leu Asn Gly Lys Ile Gln Glu Asn Thr Phe Lys Gln 
        195                 200                 205             


Gln Glu Glu Ile Ser Lys Leu Glu Glu Arg Val Tyr Asn Val Ser Ala 
    210                 215                 220                 


Glu Ile Met Ala Met Lys Glu Glu Gln Val His Leu Glu Gln Glu Ile 
225                 230                 235                 240 


Lys Gly Glu Val Lys Val Leu Asn Asn Ile Thr Asn Asp Leu Arg Leu 
                245                 250                 255     


Lys Asp Trp Glu His Ser Gln Thr Leu Arg Asn Ile Thr Leu Ile Gln 
            260                 265                 270         


Gly Pro Pro Gly Pro Pro Gly Glu Lys Gly Asp Arg Gly Pro Thr Gly 
        275                 280                 285             


Glu Ser Gly Pro Arg Gly Phe Pro Gly Pro Ile Gly Pro Pro Gly Leu 
    290                 295                 300                 


Lys Gly Asp Arg Gly Ala Ile Gly Phe Pro Gly Ser Arg Gly Leu Pro 
305                 310                 315                 320 


Gly Tyr Ala Gly Arg Pro Gly Asn Ser Gly Pro Lys Gly Gln Lys Gly 
                325                 330                 335     


Glu Lys Gly Ser Gly Asn Thr Leu Ser Thr Gly Pro Ile Trp Leu Asn 
            340                 345                 350         


Glu Val Phe Cys Phe Gly Arg Glu Ser Ser Ile Glu Glu Cys Lys Ile 
        355                 360                 365             


Arg Gln Trp Gly Thr Arg Ala Cys Ser His Ser Glu Asp Ala Gly Val 
    370                 375                 380                 


Thr Cys Thr Leu 
385             


<210>  5776
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  5776

Met Lys Ser Cys Gly Ser Met Leu Gly Leu Cys Gly Gln Arg Leu Pro 
1               5                   10                  15      


Ala Ala Trp Val Leu Leu Leu Leu Pro Phe Leu Pro Leu Leu Leu Leu 
            20                  25                  30          


Ala Ala Pro Ala Pro His Arg Ala Ser Tyr Lys Pro Val Ile Val Val 
        35                  40                  45              


His Gly Leu Phe Asp Ser Ser Tyr Ser Phe Arg His Leu Leu Glu Tyr 
    50                  55                  60                  


Ile Asn Glu Thr His Pro Gly Thr Val Val Thr Val Leu Asp Leu Phe 
65                  70                  75                  80  


Asp Gly Arg Glu Ser Leu Arg Pro Leu Trp Glu Gln Val Gln Gly Phe 
                85                  90                  95      


Arg Glu Ala Val Val Pro Ile Met Ala Lys Ala Pro Gln Gly Val His 
            100                 105                 110         


Leu Ile Cys Tyr Ser Gln Gly Gly Leu Val Cys Arg Ala Leu Leu Ser 
        115                 120                 125             


Val Met Asp Asp His Asn Val Asp Ser Phe Ile Ser Leu Ser Ser Pro 
    130                 135                 140                 


Gln Met Gly Gln Tyr Gly Asp Thr Asp Tyr Leu Lys Trp Leu Phe Pro 
145                 150                 155                 160 


Thr Ser Met Arg Ser Asn Leu Tyr Arg Ile Cys Tyr Ser Pro Trp Gly 
                165                 170                 175     


Gln Glu Phe Ser Ile Cys Asn Tyr Trp His Asp Pro His His Asp Asp 
            180                 185                 190         


Leu Tyr Leu Asn Ala Ser Ser Phe Leu Ala Leu Ile Asn Gly Glu Arg 
        195                 200                 205             


Asp His Pro Asn Ala Thr Val Trp Arg Lys Asn Phe Leu Arg Val Gly 
    210                 215                 220                 


His Leu Val Leu Ile Gly Gly Pro Asp Asp Gly Val Ile Thr Pro Trp 
225                 230                 235                 240 


Gln Ser Ser Phe Phe Gly Phe Tyr Asp Ala Asn Glu Thr Val Leu Glu 
                245                 250                 255     


Met Glu Glu Gln Leu Val Tyr Leu Arg Asp Ser Phe Gly Leu Lys Thr 
            260                 265                 270         


Leu Leu Ala Arg Gly Ala Ile Val Arg Cys Pro Met Ala Gly Ile Ser 
        275                 280                 285             


His Thr Ala Trp His Ser Asn Arg Thr Leu Tyr Glu Thr Cys Ile Glu 
    290                 295                 300                 


Pro Trp Leu Ser 
305             


<210>  5777
<211>  865
<212>  PRT
<213>  Homo sapiens

<400>  5777

Met Ala Gln Leu Glu Arg Ser Ala Ile Ser Gly Phe Ser Ser Lys Ser 
1               5                   10                  15      


Arg Arg Asn Ser Phe Ala Tyr Asp Val Lys Arg Glu Val Tyr Asn Glu 
            20                  25                  30          


Glu Thr Phe Gln Gln Glu His Lys Arg Lys Ala Ser Ser Ser Gly Asn 
        35                  40                  45              


Met Asn Ile Asn Ile Thr Thr Phe Arg His His Val Gln Cys Arg Cys 
    50                  55                  60                  


Ser Trp His Arg Phe Leu Arg Cys Val Leu Thr Ile Phe Pro Phe Leu 
65                  70                  75                  80  


Glu Trp Met Cys Met Tyr Arg Leu Lys Asp Trp Leu Leu Gly Asp Leu 
                85                  90                  95      


Leu Ala Gly Ile Ser Val Gly Leu Val Gln Val Pro Gln Gly Leu Thr 
            100                 105                 110         


Leu Ser Leu Leu Ala Arg Gln Leu Ile Pro Pro Leu Asn Ile Ala Tyr 
        115                 120                 125             


Ala Ala Phe Cys Ser Ser Val Ile Tyr Val Ile Phe Gly Ser Cys His 
    130                 135                 140                 


Gln Met Ser Ile Gly Ser Phe Phe Leu Val Ser Ala Leu Leu Ile Asn 
145                 150                 155                 160 


Val Leu Lys Val Ser Pro Phe Asn Asn Gly Gln Leu Val Met Gly Ser 
                165                 170                 175     


Phe Val Lys Asn Glu Phe Ser Ala Pro Ser Tyr Leu Met Gly Tyr Asn 
            180                 185                 190         


Lys Ser Leu Ser Val Val Ala Thr Thr Thr Phe Leu Thr Gly Ile Ile 
        195                 200                 205             


Gln Ile Ile Gly Phe Thr Val Ile Ala Asn Lys Ile Ser Met Ala Thr 
    210                 215                 220                 


Glu Thr Ser Gln Thr Leu Ile Asp Met Ile Pro Tyr Ser Phe Leu Leu 
225                 230                 235                 240 


Pro Val Thr Pro Asp Phe Ser Leu Leu Pro Lys Ile Ile Leu Gln Ala 
                245                 250                 255     


Phe Ser Leu Ser Leu Val Ser Ser Phe Leu Leu Ile Phe Leu Gly Lys 
            260                 265                 270         


Lys Ile Ala Ser Leu His Asn Tyr Ser Val Asn Ser Asn Gln Asp Leu 
        275                 280                 285             


Ile Ala Ile Gly Leu Cys Asn Val Val Ser Ser Phe Phe Arg Ser Cys 
    290                 295                 300                 


Val Phe Thr Gly Ala Ile Ala Arg Thr Ile Ile Gln Asp Lys Ser Gly 
305                 310                 315                 320 


Gly Arg Gln Gln Phe Ala Ser Leu Val Gly Ala Gly Val Met Leu Leu 
                325                 330                 335     


Leu Met Val Lys Met Gly His Phe Phe Tyr Thr Leu Pro Asn Ala Val 
            340                 345                 350         


Leu Ala Gly Ile Ile Leu Ser Asn Val Ile Pro Tyr Leu Glu Thr Ile 
        355                 360                 365             


Ser Asn Leu Pro Ser Leu Trp Arg Gln Asp Gln Tyr Asp Cys Ala Leu 
    370                 375                 380                 


Trp Met Met Thr Phe Ser Ser Ser Ile Phe Leu Gly Leu Asp Ile Gly 
385                 390                 395                 400 


Leu Ile Ile Ser Val Val Ser Ala Phe Phe Ile Thr Thr Val Arg Ser 
                405                 410                 415     


His Arg Ala Lys Ile Leu Leu Leu Gly Gln Ile Pro Asn Thr Asn Ile 
            420                 425                 430         


Tyr Arg Ser Ile Asn Asp Tyr Arg Glu Ile Ile Thr Ile Pro Gly Val 
        435                 440                 445             


Lys Ile Phe Gln Cys Cys Ser Ser Ile Thr Phe Val Asn Val Tyr Tyr 
    450                 455                 460                 


Leu Lys His Lys Leu Leu Lys Glu Val Asp Met Val Lys Val Pro Leu 
465                 470                 475                 480 


Lys Glu Glu Glu Ile Phe Ser Leu Phe Asn Ser Ser Asp Thr Asn Leu 
                485                 490                 495     


Gln Gly Gly Lys Ile Cys Arg Cys Phe Cys Asn Cys Asp Asp Leu Glu 
            500                 505                 510         


Pro Leu Pro Arg Ile Leu Tyr Thr Glu Arg Phe Glu Asn Lys Leu Asp 
        515                 520                 525             


Pro Glu Ala Ser Ser Ile Asn Leu Ile His Cys Ser His Phe Glu Ser 
    530                 535                 540                 


Met Asn Thr Ser Gln Thr Ala Ser Glu Asp Gln Val Pro Tyr Thr Val 
545                 550                 555                 560 


Ser Ser Val Ser Gln Lys Asn Gln Gly Gln Gln Tyr Glu Glu Val Glu 
                565                 570                 575     


Glu Val Trp Leu Pro Asn Asn Ser Ser Arg Asn Ser Ser Pro Gly Leu 
            580                 585                 590         


Pro Asp Val Ala Glu Ser Gln Gly Arg Arg Ser Leu Ile Pro Tyr Ser 
        595                 600                 605             


Asp Ala Ser Leu Leu Pro Ser Val His Thr Ile Ile Leu Asp Phe Ser 
    610                 615                 620                 


Met Val His Tyr Val Asp Ser Arg Gly Leu Val Val Leu Arg Gln Ile 
625                 630                 635                 640 


Cys Asn Ala Phe Gln Asn Ala Asn Ile Leu Ile Leu Ile Ala Gly Cys 
                645                 650                 655     


His Ser Ser Ile Val Arg Ala Phe Glu Arg Asn Asp Phe Phe Asp Ala 
            660                 665                 670         


Gly Ile Thr Lys Thr Gln Leu Phe Leu Ser Val His Asp Ala Val Leu 
        675                 680                 685             


Phe Ala Leu Ser Arg Lys Val Ile Gly Ser Ser Glu Leu Ser Ile Asp 
    690                 695                 700                 


Glu Ser Glu Thr Val Ile Arg Glu Thr Tyr Ser Glu Thr Asp Lys Asn 
705                 710                 715                 720 


Asp Asn Ser Arg Tyr Lys Met Ser Ser Ser Phe Leu Gly Ser Gln Lys 
                725                 730                 735     


Asn Val Ser Pro Gly Phe Ile Lys Ile Gln Gln Pro Val Glu Glu Glu 
            740                 745                 750         


Ser Glu Leu Asp Leu Glu Leu Glu Ser Glu Gln Glu Ala Gly Leu Gly 
        755                 760                 765             


Leu Asp Leu Asp Leu Asp Arg Glu Leu Glu Pro Glu Met Glu Pro Lys 
    770                 775                 780                 


Ala Glu Thr Glu Thr Lys Thr Gln Thr Glu Met Glu Pro Gln Pro Glu 
785                 790                 795                 800 


Thr Glu Pro Glu Met Glu Pro Asn Pro Lys Ser Arg Pro Arg Ala His 
                805                 810                 815     


Thr Phe Pro Gln Gln Arg Tyr Trp Pro Met Tyr His Pro Ser Met Ala 
            820                 825                 830         


Ser Thr Gln Ser Gln Thr Gln Thr Arg Thr Trp Ser Val Glu Arg Arg 
        835                 840                 845             


Arg His Pro Met Asp Ser Tyr Ser Pro Glu Gly Asn Ser Asn Glu Asp 
    850                 855                 860                 


Val 
865 


<210>  5778
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  5778

Met Ala Asp Arg Gly Gly Val Gly Glu Ala Ala Ala Val Gly Ala Ser 
1               5                   10                  15      


Pro Ala Ser Val Pro Gly Leu Asn Pro Thr Leu Gly Trp Arg Glu Arg 
            20                  25                  30          


Leu Arg Ala Gly Leu Ala Gly Thr Gly Ala Ser Leu Trp Phe Val Ala 
        35                  40                  45              


Gly Leu Gly Leu Leu Tyr Ala Leu Arg Ile Pro Leu Arg Leu Cys Glu 
    50                  55                  60                  


Asn Leu Ala Ala Gly Thr Ser Ser Leu Ile Ser Gly Leu Ile Phe Ile 
65                  70                  75                  80  


Phe Glu Trp Trp Tyr Phe His Lys His Gly Thr Ser Phe Ile Glu Gln 
                85                  90                  95      


Val Ser Val Ser His Leu Gln Pro Leu Met Gly Gly Thr Glu Ser Ser 
            100                 105                 110         


Ile Ser Glu Pro Gly Ser Pro Ser Arg Asn Arg Glu Asn Glu Thr Ser 
        115                 120                 125             


Arg Gln Asn Leu Ser Glu Cys Lys Val Trp Arg Asn Pro Leu Asn Leu 
    130                 135                 140                 


Phe Arg Gly Ala Glu Tyr Arg Arg Tyr Thr Trp Val Thr Gly Lys Glu 
145                 150                 155                 160 


Pro Leu Thr Tyr Tyr Asp Met Asn Leu Ser Ala Gln Asp His Gln Thr 
                165                 170                 175     


Phe Phe Thr Cys Asp Thr Asp Phe Leu Arg Pro Ser Asp Thr Val Met 
            180                 185                 190         


Gln Lys Ala Trp Arg Glu Arg Asn Pro Pro Ala Arg Ile Lys Ala Ala 
        195                 200                 205             


Tyr Gln Ala Leu Glu Leu Asn Asn Asp Cys Ala Thr Ala Tyr Val Leu 
    210                 215                 220                 


Leu Ala Glu Glu Glu Ala Thr Thr Ile Val Asp Ala Glu Arg Leu Phe 
225                 230                 235                 240 


Lys Gln Ala Leu Lys Ala Gly Glu Thr Ile Tyr Arg Gln Ser Gln Gln 
                245                 250                 255     


Cys Gln His Gln Ser Pro Gln His Glu Ala Gln Leu Arg Arg Asp Thr 
            260                 265                 270         


Asn Val Leu Val Tyr Ile Lys Arg Arg Leu Ala Met Cys Ala Arg Lys 
        275                 280                 285             


Leu Gly Arg Ile Arg Glu Ala Val Lys Ile Met Arg Asp Leu Met Lys 
    290                 295                 300                 


Glu Phe Pro Pro Leu Thr Met Leu Asn Ile His Glu Asn Leu Leu Glu 
305                 310                 315                 320 


Ser Leu Leu Glu Leu Gln Ala Tyr Pro Asp Val Gln Ala Val Leu Ala 
                325                 330                 335     


Lys Tyr Asp Asp Ile Ser Leu Pro Lys Ser Ala Ala Ile Cys Tyr Thr 
            340                 345                 350         


Ala Ala Leu Leu Lys Thr Arg Thr Val Ser Glu Lys Phe Ser Pro Glu 
        355                 360                 365             


Thr Ala Ser Arg Arg Gly Leu Ser Thr Ala Glu Ile Asn Ala Val Glu 
    370                 375                 380                 


Ala Ile His Arg Ala Val Glu Phe Asn Pro His Val Pro Lys Tyr Leu 
385                 390                 395                 400 


Leu Glu Met Lys Ser Leu Ile Leu Pro Pro Glu His Ile Leu Lys Arg 
                405                 410                 415     


Gly Asp Ser Glu Ala Ile Ala Tyr Ala Phe Phe His Leu Gln His Trp 
            420                 425                 430         


Lys Arg Ile Glu Gly Ala Leu Asn Leu Leu Gln Cys Thr Trp Glu Gly 
        435                 440                 445             


Thr Phe Arg Met Ile Pro Tyr Pro Leu Glu Lys Gly His Leu Phe Tyr 
    450                 455                 460                 


Pro Tyr Pro Ser Cys Thr Glu Thr Ala Asp Arg Glu Leu Leu Pro Thr 
465                 470                 475                 480 


Phe His His Val Ser Val Tyr Pro Lys Lys Glu Leu Pro Leu Phe Ile 
                485                 490                 495     


His Phe Thr Ala Gly Phe Cys Ser Ser Thr Ala Met Ile Ala Ile Leu 
            500                 505                 510         


Thr His Gln Phe Pro Glu Ile Met Gly Ile Phe Ala Lys Ala Val Leu 
        515                 520                 525             


Gly Leu Trp Cys Pro Gln Pro Trp Ala Ser Ser Gly Phe Glu Glu Asn 
    530                 535                 540                 


Thr Gln Asp Leu Lys Ser Glu Asp Leu Gly Leu Ser Ser Gly 
545                 550                 555             


<210>  5779
<211>  544
<212>  PRT
<213>  Homo sapiens

<400>  5779

Met Ala Asp Arg Gly Gly Val Gly Glu Ala Ala Ala Val Gly Ala Ser 
1               5                   10                  15      


Pro Ala Ser Val Pro Gly Leu Asn Pro Thr Leu Gly Trp Arg Glu Arg 
            20                  25                  30          


Leu Arg Ala Gly Leu Ala Gly Thr Gly Ala Ser Leu Trp Phe Val Ala 
        35                  40                  45              


Gly Leu Gly Leu Leu Tyr Ala Leu Arg Ile Pro Leu Arg Leu Cys Glu 
    50                  55                  60                  


Asn Leu Ala Ala Val Thr Val Phe Leu Asn Ser Leu Thr Pro Lys Phe 
65                  70                  75                  80  


Tyr Val Ala Leu Thr Gly Thr Ser Ser Leu Ile Ser Gly Leu Ile Phe 
                85                  90                  95      


Ile Phe Glu Trp Trp Tyr Phe His Lys His Gly Thr Ser Phe Ile Glu 
            100                 105                 110         


Gln Val Ser Val Ser His Leu Gln Pro Leu Met Gly Gly Thr Glu Ser 
        115                 120                 125             


Ser Ile Ser Glu Pro Gly Ser Pro Ser Arg Asn Arg Glu Asn Glu Thr 
    130                 135                 140                 


Ser Arg Gln Asn Leu Ser Glu Cys Lys Val Trp Arg Asn Pro Leu Asn 
145                 150                 155                 160 


Leu Phe Arg Gly Ala Glu Tyr Arg Arg Tyr Thr Trp Val Thr Gly Lys 
                165                 170                 175     


Glu Pro Leu Thr Tyr Tyr Asp Met Asn Leu Ser Ala Gln Asp His Gln 
            180                 185                 190         


Thr Phe Phe Thr Cys Asp Thr Asp Phe Leu Arg Pro Ser Asp Thr Val 
        195                 200                 205             


Met Gln Lys Ala Trp Arg Glu Arg Asn Pro Pro Ala Arg Ile Lys Ala 
    210                 215                 220                 


Ala Tyr Gln Ala Leu Glu Leu Asn Asn Asp Cys Ala Thr Ala Tyr Val 
225                 230                 235                 240 


Leu Leu Ala Glu Glu Glu Ala Thr Thr Ile Val Asp Ala Glu Arg Leu 
                245                 250                 255     


Phe Lys Gln Ala Leu Lys Ala Gly Glu Thr Ile Tyr Arg Gln Ser Gln 
            260                 265                 270         


Gln Cys Gln His Gln Ser Pro Gln His Glu Ala Gln Leu Arg Arg Asp 
        275                 280                 285             


Thr Asn Val Leu Val Tyr Ile Lys Arg Arg Leu Ala Met Cys Ala Arg 
    290                 295                 300                 


Lys Leu Gly Arg Ile Arg Glu Ala Val Lys Ile Met Arg Asp Leu Met 
305                 310                 315                 320 


Lys Glu Phe Pro Pro Leu Thr Met Leu Asn Ile His Glu Asn Leu Leu 
                325                 330                 335     


Glu Ser Leu Leu Glu Leu Gln Ala Tyr Pro Asp Val Gln Ala Val Leu 
            340                 345                 350         


Ala Lys Tyr Asp Asp Ile Ser Leu Pro Lys Ser Ala Ala Ile Cys Tyr 
        355                 360                 365             


Thr Ala Ala Leu Leu Lys Thr Arg Thr Val Ser Glu Lys Phe Ser Pro 
    370                 375                 380                 


Glu Thr Ala Ser Arg Arg Gly Leu Ser Thr Ala Glu Ile Asn Ala Val 
385                 390                 395                 400 


Glu Ala Ile His Arg Ala Val Glu Phe Asn Pro His Val Pro Lys Tyr 
                405                 410                 415     


Leu Leu Glu Met Lys Ser Leu Ile Leu Pro Pro Glu His Ile Leu Lys 
            420                 425                 430         


Arg Gly Asp Ser Glu Ala Ile Ala Tyr Ala Phe Phe His Leu Gln His 
        435                 440                 445             


Trp Lys Arg Ile Glu Gly Ala Leu Asn Leu Leu Gln Cys Thr Trp Glu 
    450                 455                 460                 


Gly Thr Phe His His Val Ser Val Tyr Pro Lys Lys Glu Leu Pro Leu 
465                 470                 475                 480 


Phe Ile His Phe Thr Ala Gly Phe Cys Ser Ser Thr Ala Met Ile Ala 
                485                 490                 495     


Ile Leu Thr His Gln Phe Pro Glu Ile Met Gly Ile Phe Ala Lys Ala 
            500                 505                 510         


Val Leu Gly Leu Trp Cys Pro Gln Pro Trp Ala Ser Ser Gly Phe Glu 
        515                 520                 525             


Glu Asn Thr Gln Asp Leu Lys Ser Glu Asp Leu Gly Leu Ser Ser Gly 
    530                 535                 540                 


<210>  5780
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  5780

Met Ala Asp Arg Gly Gly Val Gly Glu Ala Ala Ala Val Gly Ala Ser 
1               5                   10                  15      


Pro Ala Ser Val Pro Gly Leu Asn Pro Thr Leu Gly Trp Arg Glu Arg 
            20                  25                  30          


Leu Arg Ala Gly Leu Ala Gly Thr Gly Ala Ser Leu Trp Phe Val Ala 
        35                  40                  45              


Gly Leu Gly Leu Leu Tyr Ala Leu Arg Ile Pro Leu Arg Leu Cys Glu 
    50                  55                  60                  


Asn Leu Ala Ala Val Thr Val Phe Leu Asn Ser Leu Thr Pro Lys Phe 
65                  70                  75                  80  


Tyr Val Ala Leu Thr Gly Thr Ser Ser Leu Ile Ser Gly Leu Ile Phe 
                85                  90                  95      


Ile Phe Glu Trp Trp Tyr Phe His Lys His Gly Thr Ser Phe Ile Glu 
            100                 105                 110         


Gln Val Ser Val Ser His Leu Gln Pro Leu Met Gly Gly Thr Glu Ser 
        115                 120                 125             


Ser Ile Ser Glu Pro Gly Ser Pro Ser Arg Asn Arg Glu Asn Glu Thr 
    130                 135                 140                 


Ser Arg Gln Asn Leu Ser Glu Cys Lys Val Trp Arg Asn Pro Leu Asn 
145                 150                 155                 160 


Leu Phe Arg Gly Ala Glu Tyr Arg Arg Tyr Thr Trp Val Thr Gly Lys 
                165                 170                 175     


Glu Pro Leu Thr Tyr Tyr Asp Met Asn Leu Ser Ala Gln Asp His Gln 
            180                 185                 190         


Thr Phe Phe Thr Cys Asp Thr Asp Phe Leu Arg Pro Ser Asp Thr Val 
        195                 200                 205             


Met Gln Lys Ala Trp Arg Glu Arg Asn Pro Pro Ala Arg Ile Lys Ala 
    210                 215                 220                 


Ala Tyr Gln Ala Leu Glu Leu Asn Asn Asp Cys Ala Thr Ala Tyr Val 
225                 230                 235                 240 


Leu Leu Ala Glu Glu Glu Ala Thr Thr Ile Val Asp Ala Glu Arg Leu 
                245                 250                 255     


Phe Lys Gln Ala Leu Lys Ala Gly Glu Thr Ile Tyr Arg Gln Ser Gln 
            260                 265                 270         


Gln Cys Gln His Gln Ser Pro Gln His Glu Ala Gln Leu Arg Arg Asp 
        275                 280                 285             


Thr Asn Val Leu Val Tyr Ile Lys Arg Arg Leu Ala Met Cys Ala Arg 
    290                 295                 300                 


Lys Leu Gly Arg Ile Arg Glu Ala Val Lys Ile Met Arg Asp Leu Met 
305                 310                 315                 320 


Lys Glu Phe Pro Pro Leu Thr Met Leu Asn Ile His Glu Asn Leu Leu 
                325                 330                 335     


Glu Ser Leu Leu Glu Leu Gln Ala Tyr Pro Asp Val Gln Ala Val Leu 
            340                 345                 350         


Ala Lys Tyr Asp Asp Ile Ser Leu Pro Lys Ser Ala Ala Ile Cys Tyr 
        355                 360                 365             


Thr Ala Ala Leu Leu Lys Thr Arg Thr Val Ser Glu Lys Phe Ser Pro 
    370                 375                 380                 


Glu Thr Ala Ser Arg Arg Gly Leu Ser Thr Ala Glu Ile Asn Ala Val 
385                 390                 395                 400 


Glu Ala Ile His Arg Ala Val Glu Phe Asn Pro His Val Pro Lys Tyr 
                405                 410                 415     


Leu Leu Glu Met Lys Ser Leu Ile Leu Pro Pro Glu His Ile Leu Lys 
            420                 425                 430         


Arg Gly Asp Ser Glu Ala Ile Ala Tyr Ala Phe Phe His Leu Gln His 
        435                 440                 445             


Trp Lys Arg Ile Glu Gly Ala Leu Asn Leu Leu Gln Cys Thr Trp Glu 
    450                 455                 460                 


Gly Thr Phe Arg Met Ile Pro Tyr Pro Leu Glu Lys Gly His Leu Phe 
465                 470                 475                 480 


Tyr Pro Tyr Pro Ser Cys Thr Glu Thr Ala Asp Arg Glu Leu Leu Pro 
                485                 490                 495     


Thr Phe His His Val Ser Val Tyr Pro Lys Lys Glu Leu Pro Leu Phe 
            500                 505                 510         


Ile His Phe Thr Ala Gly Phe Cys Ser Ser Thr Ala Met Ile Ala Ile 
        515                 520                 525             


Leu Thr His Gln Phe Pro Glu Ile Met Gly Ile Phe Ala Lys Ala Val 
    530                 535                 540                 


Ser Met Ile Ser Arg Thr Cys Val Asp Tyr Leu 
545                 550                 555 


<210>  5781
<211>  1642
<212>  PRT
<213>  Homo sapiens

<400>  5781

Met Ala Ser Gly Ser Arg Trp Arg Pro Thr Pro Pro Pro Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ala Leu Ala Ala Arg Ala Asp Gly Leu Glu Phe Gly 
            20                  25                  30          


Gly Gly Pro Gly Gln Trp Ala Arg Tyr Ala Arg Trp Ala Gly Ala Ala 
        35                  40                  45              


Ser Ser Gly Glu Leu Ser Phe Ser Leu Arg Thr Asn Ala Thr Arg Ala 
    50                  55                  60                  


Leu Leu Leu Tyr Leu Asp Asp Gly Gly Asp Cys Asp Phe Leu Glu Leu 
65                  70                  75                  80  


Leu Leu Val Asp Gly Arg Leu Arg Leu Arg Phe Thr Leu Ser Cys Ala 
                85                  90                  95      


Glu Pro Ala Thr Leu Gln Leu Asp Thr Pro Val Ala Asp Asp Arg Trp 
            100                 105                 110         


His Met Val Leu Leu Thr Arg Asp Ala Arg Arg Thr Ala Leu Ala Val 
        115                 120                 125             


Asp Gly Glu Ala Arg Ala Ala Glu Val Arg Ser Lys Arg Arg Glu Met 
    130                 135                 140                 


Gln Val Ala Ser Asp Leu Phe Val Gly Gly Ile Pro Pro Asp Val Arg 
145                 150                 155                 160 


Leu Ser Ala Leu Thr Leu Ser Thr Val Lys Tyr Glu Pro Pro Phe Arg 
                165                 170                 175     


Gly Leu Leu Ala Asn Leu Lys Leu Gly Glu Arg Pro Pro Ala Leu Leu 
            180                 185                 190         


Gly Ser Gln Gly Leu Arg Gly Ala Thr Ala Asp Pro Leu Cys Ala Pro 
        195                 200                 205             


Ala Arg Asn Pro Cys Ala Asn Gly Gly Leu Cys Thr Val Leu Ala Pro 
    210                 215                 220                 


Gly Glu Val Gly Cys Asp Cys Ser His Thr Gly Phe Gly Gly Lys Phe 
225                 230                 235                 240 


Cys Ser Glu Glu Glu His Pro Met Glu Gly Pro Ala His Leu Thr Leu 
                245                 250                 255     


Asn Ser Glu Gly Lys Glu Glu Phe Val Ala Thr Phe Lys Gly Asn Glu 
            260                 265                 270         


Phe Phe Cys Tyr Asp Leu Ser His Asn Pro Ile Gln Ser Ser Thr Asp 
        275                 280                 285             


Glu Ile Thr Leu Ala Phe Arg Thr Leu Gln Arg Asn Gly Leu Met Leu 
    290                 295                 300                 


His Thr Gly Lys Ser Ala Asp Tyr Val Asn Leu Ser Leu Lys Ser Gly 
305                 310                 315                 320 


Ala Val Trp Leu Val Ile Asn Leu Gly Ser Gly Ala Phe Glu Ala Leu 
                325                 330                 335     


Val Glu Pro Val Asn Gly Lys Phe Asn Asp Asn Ala Trp His Asp Val 
            340                 345                 350         


Arg Val Thr Arg Asn Leu Arg Gln His Ala Gly Ile Gly His Ala Met 
        355                 360                 365             


Val Thr Ile Ser Val Asp Gly Ile Leu Thr Thr Thr Gly Tyr Thr Gln 
    370                 375                 380                 


Glu Asp Tyr Thr Met Leu Gly Ser Asp Asp Phe Phe Tyr Ile Gly Gly 
385                 390                 395                 400 


Ser Pro Asn Thr Ala Asp Leu Pro Gly Ser Pro Val Ser Asn Asn Phe 
                405                 410                 415     


Met Gly Cys Leu Lys Asp Val Val Tyr Lys Asn Asn Asp Phe Lys Leu 
            420                 425                 430         


Glu Leu Ser Arg Leu Ala Lys Glu Gly Asp Pro Lys Met Lys Leu Gln 
        435                 440                 445             


Gly Asp Leu Ser Phe Arg Cys Glu Asp Val Ala Ala Leu Asp Pro Val 
    450                 455                 460                 


Thr Phe Glu Ser Pro Glu Ala Phe Val Ala Leu Pro Arg Trp Ser Ala 
465                 470                 475                 480 


Lys Arg Thr Gly Ser Ile Ser Leu Asp Phe Arg Thr Thr Glu Pro Asn 
                485                 490                 495     


Gly Leu Leu Leu Phe Ser Gln Gly Arg Arg Ala Gly Gly Gly Ala Gly 
            500                 505                 510         


Ser His Ser Ser Ala Gln Arg Ala Asp Tyr Phe Ala Met Glu Leu Leu 
        515                 520                 525             


Asp Gly His Leu Tyr Leu Leu Leu Asp Met Gly Ser Gly Gly Ile Lys 
    530                 535                 540                 


Leu Arg Ala Ser Ser Arg Lys Val Asn Asp Gly Glu Trp Cys His Val 
545                 550                 555                 560 


Asp Phe Gln Arg Asp Gly Arg Lys Gly Ser Ile Ser Val Asn Ser Arg 
                565                 570                 575     


Ser Thr Pro Phe Leu Ala Thr Gly Asp Ser Glu Ile Leu Asp Leu Glu 
            580                 585                 590         


Ser Glu Leu Tyr Leu Gly Gly Leu Pro Glu Gly Gly Arg Val Asp Leu 
        595                 600                 605             


Pro Leu Pro Pro Glu Val Trp Thr Ala Ala Leu Arg Ala Gly Tyr Val 
    610                 615                 620                 


Gly Cys Val Arg Asp Leu Phe Ile Asp Gly Arg Ser Arg Asp Leu Arg 
625                 630                 635                 640 


Gly Leu Ala Glu Ala Gln Gly Ala Val Gly Val Ala Pro Phe Cys Ser 
                645                 650                 655     


Arg Glu Thr Leu Lys Gln Cys Ala Ser Ala Pro Cys Arg Asn Gly Gly 
            660                 665                 670         


Val Cys Arg Glu Gly Trp Asn Arg Phe Ile Cys Asp Cys Ile Gly Thr 
        675                 680                 685             


Gly Phe Leu Gly Arg Val Cys Glu Arg Glu Ala Thr Val Leu Ser Tyr 
    690                 695                 700                 


Asp Gly Ser Met Tyr Met Lys Ile Met Leu Pro Asn Ala Met His Thr 
705                 710                 715                 720 


Glu Ala Glu Asp Val Ser Leu Arg Phe Met Ser Gln Arg Ala Tyr Gly 
                725                 730                 735     


Leu Met Met Ala Thr Thr Ser Arg Glu Ser Ala Asp Thr Leu Arg Leu 
            740                 745                 750         


Glu Leu Asp Gly Gly Gln Met Lys Leu Thr Val Asn Leu Gly Lys Gly 
        755                 760                 765             


Pro Glu Thr Leu Phe Ala Gly His Lys Leu Asn Asp Asn Glu Trp His 
    770                 775                 780                 


Thr Val Arg Val Val Arg Arg Gly Lys Ser Leu Gln Leu Ser Val Asp 
785                 790                 795                 800 


Asn Val Thr Val Glu Gly Gln Met Ala Gly Ala His Met Arg Leu Glu 
                805                 810                 815     


Phe His Asn Ile Glu Thr Gly Ile Met Thr Glu Arg Arg Phe Ile Ser 
            820                 825                 830         


Val Val Pro Ser Asn Phe Ile Gly His Leu Ser Gly Leu Val Phe Asn 
        835                 840                 845             


Gly Gln Pro Tyr Met Asp Gln Cys Lys Asp Gly Asp Ile Thr Tyr Cys 
    850                 855                 860                 


Glu Leu Asn Ala Arg Phe Gly Leu Arg Ala Ile Val Ala Asp Pro Val 
865                 870                 875                 880 


Thr Phe Lys Ser Arg Ser Ser Tyr Leu Ala Leu Ala Thr Leu Gln Ala 
                885                 890                 895     


Tyr Ala Ser Met His Leu Phe Phe Gln Phe Lys Thr Thr Ala Pro Asp 
            900                 905                 910         


Gly Leu Leu Leu Phe Asn Ser Gly Asn Gly Asn Asp Phe Ile Val Ile 
        915                 920                 925             


Glu Leu Val Lys Gly Tyr Ile His Tyr Val Phe Asp Leu Gly Asn Gly 
    930                 935                 940                 


Pro Ser Leu Met Lys Gly Asn Ser Asp Lys Pro Val Asn Asp Asn Gln 
945                 950                 955                 960 


Trp His Asn Val Val Val Ser Arg Asp Pro Gly Asn Val His Thr Leu 
                965                 970                 975     


Lys Ile Asp Ser Arg Thr Val Thr Gln His Ser Asn Gly Ala Arg Asn 
            980                 985                 990         


Leu Asp Leu Lys Gly Glu Leu Tyr  Ile Gly Gly Leu Ser  Lys Asn Met 
        995                 1000                 1005             


Phe Ser  Asn Leu Pro Lys Leu  Val Ala Ser Arg Asp  Gly Phe Gln 
    1010                 1015                 1020             


Gly Cys  Leu Ala Ser Val Asp  Leu Asn Gly Arg Leu  Pro Asp Leu 
    1025                 1030                 1035             


Ile Ala  Asp Ala Leu His Arg  Ile Gly Gln Val Glu  Arg Gly Cys 
    1040                 1045                 1050             


Asp Gly  Pro Ser Thr Thr Cys  Thr Glu Glu Ser Cys  Ala Asn Gln 
    1055                 1060                 1065             


Gly Val  Cys Leu Gln Gln Trp  Asp Gly Phe Thr Cys  Asp Cys Thr 
    1070                 1075                 1080             


Met Thr  Ser Tyr Gly Gly Pro  Val Cys Asn Asp Pro  Gly Thr Thr 
    1085                 1090                 1095             


Tyr Ile  Phe Gly Lys Gly Gly  Ala Leu Ile Thr Tyr  Thr Trp Pro 
    1100                 1105                 1110             


Pro Asn  Asp Arg Pro Ser Thr  Arg Met Asp Arg Leu  Ala Val Gly 
    1115                 1120                 1125             


Phe Ser  Thr His Gln Arg Ser  Ala Val Leu Val Arg  Val Asp Ser 
    1130                 1135                 1140             


Ala Ser  Gly Leu Gly Asp Tyr  Leu Gln Leu His Ile  Asp Gln Gly 
    1145                 1150                 1155             


Thr Val  Gly Val Ile Phe Asn  Val Gly Thr Asp Asp  Ile Thr Ile 
    1160                 1165                 1170             


Asp Glu  Pro Asn Ala Ile Val  Ser Asp Gly Lys Tyr  His Val Val 
    1175                 1180                 1185             


Arg Phe  Thr Arg Ser Gly Gly  Asn Ala Thr Leu Gln  Val Asp Ser 
    1190                 1195                 1200             


Trp Pro  Val Asn Glu Arg Tyr  Pro Ala Gly Arg Gln  Leu Thr Ile 
    1205                 1210                 1215             


Phe Asn  Ser Gln Ala Ala Ile  Lys Ile Gly Gly Arg  Asp Gln Gly 
    1220                 1225                 1230             


Arg Pro  Phe Gln Gly Gln Val  Ser Gly Leu Tyr Tyr  Asn Gly Leu 
    1235                 1240                 1245             


Lys Val  Leu Ala Leu Ala Ala  Glu Ser Asp Pro Asn  Val Arg Thr 
    1250                 1255                 1260             


Glu Gly  His Leu Arg Leu Val  Gly Glu Gly Pro Ser  Val Leu Leu 
    1265                 1270                 1275             


Ser Ala  Glu Thr Thr Ala Thr  Thr Leu Leu Ala Asp  Met Ala Thr 
    1280                 1285                 1290             


Thr Ile  Met Glu Thr Thr Thr  Thr Met Ala Thr Thr  Thr Thr Arg 
    1295                 1300                 1305             


Arg Gly  Arg Ser Pro Thr Leu  Arg Asp Ser Thr Thr  Gln Asn Thr 
    1310                 1315                 1320             


Asp Asp  Leu Leu Val Ala Ser  Ala Glu Cys Pro Ser  Asp Asp Glu 
    1325                 1330                 1335             


Asp Leu  Glu Glu Cys Glu Pro  Ser Thr Gly Gly Glu  Leu Ile Leu 
    1340                 1345                 1350             


Pro Ile  Ile Thr Glu Asp Ser  Leu Asp Pro Pro Pro  Val Ala Thr 
    1355                 1360                 1365             


Arg Ser  Pro Phe Val Pro Pro  Pro Pro Thr Phe Tyr  Pro Phe Leu 
    1370                 1375                 1380             


Thr Gly  Val Gly Ala Thr Gln  Asp Thr Leu Pro Pro  Pro Ala Ala 
    1385                 1390                 1395             


Arg Arg  Pro Pro Ser Gly Gly  Pro Cys Gln Ala Glu  Arg Asp Asp 
    1400                 1405                 1410             


Ser Asp  Cys Glu Glu Pro Ile  Glu Ala Ser Gly Phe  Ala Ser Gly 
    1415                 1420                 1425             


Glu Val  Phe Asp Ser Ser Leu  Pro Pro Thr Asp Asp  Glu Asp Phe 
    1430                 1435                 1440             


Tyr Thr  Thr Phe Pro Leu Val  Thr Asp Arg Thr Thr  Leu Leu Ser 
    1445                 1450                 1455             


Pro Arg  Lys Pro Ala Pro Arg  Pro Asn Leu Arg Thr  Asp Gly Ala 
    1460                 1465                 1470             


Thr Gly  Ala Pro Gly Val Leu  Phe Ala Pro Ser Ala  Pro Ala Pro 
    1475                 1480                 1485             


Asn Leu  Pro Ala Gly Lys Met  Asn His Arg Asp Pro  Leu Gln Pro 
    1490                 1495                 1500             


Leu Leu  Glu Asn Pro Pro Leu  Gly Pro Gly Ala Pro  Thr Ser Phe 
    1505                 1510                 1515             


Glu Pro  Arg Arg Pro Pro Pro  Leu Arg Pro Gly Val  Thr Ser Ala 
    1520                 1525                 1530             


Pro Gly  Phe Pro His Leu Pro  Thr Ala Asn Pro Thr  Gly Pro Gly 
    1535                 1540                 1545             


Glu Arg  Gly Pro Pro Gly Ala  Val Glu Val Ile Arg  Glu Ser Ser 
    1550                 1555                 1560             


Ser Thr  Thr Gly Met Val Val  Gly Ile Val Ala Ala  Ala Ala Leu 
    1565                 1570                 1575             


Cys Ile  Leu Ile Leu Leu Tyr  Ala Met Tyr Lys Tyr  Arg Asn Arg 
    1580                 1585                 1590             


Asp Glu  Gly Ser Tyr Gln Val  Asp Gln Ser Arg Asn  Tyr Ile Ser 
    1595                 1600                 1605             


Asn Ser  Ala Gln Ser Asn Gly  Ala Val Val Lys Glu  Lys Ala Pro 
    1610                 1615                 1620             


Ala Ala  Pro Lys Thr Pro Ser  Lys Ala Lys Lys Asn  Lys Asp Lys 
    1625                 1630                 1635             


Glu Tyr  Tyr Val 
    1640         


<210>  5782
<211>  666
<212>  PRT
<213>  Homo sapiens

<400>  5782

Met Pro Pro Gly Gly Ser Gly Pro Gly Gly Cys Pro Arg Arg Pro Pro 
1               5                   10                  15      


Ala Leu Ala Gly Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
            20                  25                  30          


Leu Leu Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Leu Gly Ala Ala 
        35                  40                  45              


Glu Gly Ala Arg Val Ser Ser Ser Leu Ser Thr Thr His His Val His 
    50                  55                  60                  


His Phe His Ser Lys His Gly Thr Val Pro Ile Ala Ile Asn Arg Met 
65                  70                  75                  80  


Pro Phe Leu Thr Arg Gly Gly His Ala Gly Thr Thr Tyr Ile Phe Gly 
                85                  90                  95      


Lys Gly Gly Ala Leu Ile Thr Tyr Thr Trp Pro Pro Asn Asp Arg Pro 
            100                 105                 110         


Ser Thr Arg Met Asp Arg Leu Ala Val Gly Phe Ser Thr His Gln Arg 
        115                 120                 125             


Ser Ala Val Leu Val Arg Val Asp Ser Ala Ser Gly Leu Gly Asp Tyr 
    130                 135                 140                 


Leu Gln Leu His Ile Asp Gln Gly Thr Val Gly Val Ile Phe Asn Val 
145                 150                 155                 160 


Gly Thr Asp Asp Ile Thr Ile Asp Glu Pro Asn Ala Ile Val Ser Asp 
                165                 170                 175     


Gly Lys Tyr His Val Val Arg Phe Thr Arg Ser Gly Gly Asn Ala Thr 
            180                 185                 190         


Leu Gln Val Asp Ser Trp Pro Val Asn Glu Arg Tyr Pro Ala Gly Asn 
        195                 200                 205             


Phe Asp Asn Glu Arg Leu Ala Ile Ala Arg Gln Arg Ile Pro Tyr Arg 
    210                 215                 220                 


Leu Gly Arg Val Val Asp Glu Trp Leu Leu Asp Lys Gly Arg Gln Leu 
225                 230                 235                 240 


Thr Ile Phe Asn Ser Gln Ala Ala Ile Lys Ile Gly Gly Arg Asp Gln 
                245                 250                 255     


Gly Arg Pro Phe Gln Gly Gln Val Ser Gly Leu Tyr Tyr Asn Gly Leu 
            260                 265                 270         


Lys Val Leu Ala Leu Ala Ala Glu Ser Asp Pro Asn Val Arg Thr Glu 
        275                 280                 285             


Gly His Leu Arg Leu Val Gly Glu Gly Pro Ser Val Leu Leu Ser Ala 
    290                 295                 300                 


Glu Thr Thr Ala Thr Thr Leu Leu Ala Asp Met Ala Thr Thr Ile Met 
305                 310                 315                 320 


Glu Thr Thr Thr Thr Met Ala Thr Thr Thr Thr Arg Arg Gly Arg Ser 
                325                 330                 335     


Pro Thr Leu Arg Asp Ser Thr Thr Gln Asn Thr Asp Asp Leu Leu Val 
            340                 345                 350         


Ala Ser Ala Glu Cys Pro Ser Asp Asp Glu Asp Leu Glu Glu Cys Glu 
        355                 360                 365             


Pro Ser Thr Gly Gly Glu Leu Ile Leu Pro Ile Ile Thr Glu Asp Ser 
    370                 375                 380                 


Leu Asp Pro Pro Pro Val Ala Thr Arg Ser Pro Phe Val Pro Pro Pro 
385                 390                 395                 400 


Pro Thr Phe Tyr Pro Phe Leu Thr Gly Val Gly Ala Thr Gln Asp Thr 
                405                 410                 415     


Leu Pro Pro Pro Ala Ala Arg Arg Pro Pro Ser Gly Gly Pro Cys Gln 
            420                 425                 430         


Ala Glu Arg Asp Asp Ser Asp Cys Glu Glu Pro Ile Glu Ala Ser Gly 
        435                 440                 445             


Phe Ala Ser Gly Glu Val Phe Asp Ser Ser Leu Pro Pro Thr Asp Asp 
    450                 455                 460                 


Glu Asp Phe Tyr Thr Thr Phe Pro Leu Val Thr Asp Arg Thr Thr Leu 
465                 470                 475                 480 


Leu Ser Pro Arg Lys Pro Ala Pro Arg Pro Asn Leu Arg Thr Asp Gly 
                485                 490                 495     


Ala Thr Gly Ala Pro Gly Val Leu Phe Ala Pro Ser Ala Pro Ala Pro 
            500                 505                 510         


Asn Leu Pro Ala Gly Lys Met Asn His Arg Asp Pro Leu Gln Pro Leu 
        515                 520                 525             


Leu Glu Asn Pro Pro Leu Gly Pro Gly Ala Pro Thr Ser Phe Glu Pro 
    530                 535                 540                 


Arg Arg Pro Pro Pro Leu Arg Pro Gly Val Thr Ser Ala Pro Gly Phe 
545                 550                 555                 560 


Pro His Leu Pro Thr Ala Asn Pro Thr Gly Pro Gly Glu Arg Gly Pro 
                565                 570                 575     


Pro Gly Ala Val Glu Val Ile Arg Glu Ser Ser Ser Thr Thr Gly Met 
            580                 585                 590         


Val Val Gly Ile Val Ala Ala Ala Ala Leu Cys Ile Leu Ile Leu Leu 
        595                 600                 605             


Tyr Ala Met Tyr Lys Tyr Arg Asn Arg Asp Glu Gly Ser Tyr Gln Val 
    610                 615                 620                 


Asp Gln Ser Arg Asn Tyr Ile Ser Asn Ser Ala Gln Ser Asn Gly Ala 
625                 630                 635                 640 


Val Val Lys Glu Lys Ala Pro Ala Ala Pro Lys Thr Pro Ser Lys Ala 
                645                 650                 655     


Lys Lys Asn Lys Asp Lys Glu Tyr Tyr Val 
            660                 665     


<210>  5783
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  5783

Met Tyr Gln Arg Met Leu Arg Cys Gly Ala Glu Leu Gly Ser Pro Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly Gly Arg Leu Ala 
            20                  25                  30          


Leu Leu Trp Ile Val Pro Leu Thr Leu Ser Gly Leu Leu Gly Val Ala 
        35                  40                  45              


Trp Gly Ala Ser Ser Leu Gly Ala His His Ile His His Phe His Gly 
    50                  55                  60                  


Ser Ser Lys His His Ser Val Pro Ile Ala Ile Tyr Arg Ser Pro Ala 
65                  70                  75                  80  


Ser Leu Arg Gly Gly His Ala Gly Thr Thr Tyr Ile Phe Ser Lys Gly 
                85                  90                  95      


Gly Gly Gln Ile Thr Tyr Lys Trp Pro Pro Asn Asp Arg Pro Ser Thr 
            100                 105                 110         


Arg Ala Asp Arg Leu Ala Ile Gly Phe Ser Thr Val Gln Lys Glu Ala 
        115                 120                 125             


Val Leu Val Arg Val Asp Ser Ser Ser Gly Leu Gly Asp Tyr Leu Glu 
    130                 135                 140                 


Leu His Ile His Gln Gly Lys Ile Gly Val Lys Phe Asn Val Gly Thr 
145                 150                 155                 160 


Asp Asp Ile Ala Ile Glu Glu Ser Asn Ala Ile Ile Asn Asp Gly Lys 
                165                 170                 175     


Tyr His Val Val Arg Phe Thr Arg Ser Gly Gly Asn Ala Thr Leu Gln 
            180                 185                 190         


Val Asp Ser Trp Pro Val Ile Glu Arg Tyr Pro Ala Gly Arg Gln Leu 
        195                 200                 205             


Thr Ile Phe Asn Ser Gln Ala Thr Ile Ile Ile Gly Gly Lys Glu Gln 
    210                 215                 220                 


Gly Gln Pro Phe Gln Gly Gln Leu Ser Gly Leu Tyr Tyr Asn Gly Leu 
225                 230                 235                 240 


Lys Val Leu Asn Met Ala Ala Glu Asn Asp Ala Asn Ile Ala Ile Val 
                245                 250                 255     


Gly Asn Val Arg Leu Val Gly Glu Val Pro Ser Ser Met Thr Thr Glu 
            260                 265                 270         


Ser Thr Ala Thr Ala Met Gln Ser Glu Met Ser Thr Ser Ile Met Glu 
        275                 280                 285             


Thr Thr Thr Thr Leu Ala Thr Ser Thr Ala Arg Arg Gly Lys Pro Pro 
    290                 295                 300                 


Thr Lys Glu Pro Ile Ser Gln Thr Thr Asp Asp Ile Leu Val Ala Ser 
305                 310                 315                 320 


Ala Glu Cys Pro Ser Asp Asp Glu Asp Ile Asp Pro Cys Glu Pro Ser 
                325                 330                 335     


Ser Gly Gly Leu Ala Asn Pro Thr Arg Ala Gly Gly Arg Glu Pro Tyr 
            340                 345                 350         


Pro Gly Ser Ala Glu Val Ile Arg Glu Ser Ser Ser Thr Thr Gly Met 
        355                 360                 365             


Val Val Gly Ile Val Ala Ala Ala Ala Leu Cys Ile Leu Ile Leu Leu 
    370                 375                 380                 


Tyr Ala Met Tyr Lys Tyr Arg Asn Arg Asp Glu Gly Ser Tyr His Val 
385                 390                 395                 400 


Asp Glu Ser Arg Asn Tyr Ile Ser Asn Ser Ala Gln Ser Asn Gly Ala 
                405                 410                 415     


Val Val Lys Glu Lys Gln Pro Ser Ser Ala Lys Ser Ser Asn Lys Asn 
            420                 425                 430         


Lys Lys Asn Lys Asp Lys Glu Tyr Tyr Val 
        435                 440         


<210>  5784
<211>  1212
<212>  PRT
<213>  Homo sapiens

<400>  5784

Met Thr Gln Thr Leu Pro Tyr His Leu Ser Leu Leu Asn Val Leu Phe 
1               5                   10                  15      


Pro Gly Pro Cys Ser Arg His Phe Lys Phe Arg Arg Gly Lys Cys Ala 
            20                  25                  30          


Gln Pro Ala Trp Arg Lys Val Ser Ala Pro Ser Gln Asp Leu Leu Ile 
        35                  40                  45              


Thr Lys Val Met Trp Ala Met Glu Ser Gly His Leu Leu Trp Ala Leu 
    50                  55                  60                  


Leu Phe Met Gln Ser Leu Trp Pro Gln Leu Thr Asp Gly Ala Thr Arg 
65                  70                  75                  80  


Val Tyr Tyr Leu Gly Ile Arg Asp Val Gln Trp Asn Tyr Ala Pro Lys 
                85                  90                  95      


Gly Arg Asn Val Ile Thr Asn Gln Pro Leu Asp Ser Asp Ile Val Ala 
            100                 105                 110         


Ser Ser Phe Leu Lys Ser Asp Lys Asn Arg Ile Gly Gly Thr Tyr Lys 
        115                 120                 125             


Lys Thr Ile Tyr Lys Glu Tyr Lys Asp Asp Ser Tyr Thr Asp Glu Val 
    130                 135                 140                 


Ala Gln Pro Ala Trp Leu Gly Phe Leu Gly Pro Val Leu Gln Ala Glu 
145                 150                 155                 160 


Val Gly Asp Val Ile Leu Ile His Leu Lys Asn Phe Ala Thr Arg Pro 
                165                 170                 175     


Tyr Thr Ile His Pro His Gly Val Phe Tyr Glu Lys Asp Ser Glu Gly 
            180                 185                 190         


Ser Leu Tyr Pro Asp Gly Ser Ser Gly Pro Leu Lys Ala Asp Asp Ser 
        195                 200                 205             


Val Pro Pro Gly Gly Ser His Ile Tyr Asn Trp Thr Ile Pro Glu Gly 
    210                 215                 220                 


His Ala Pro Thr Asp Ala Asp Pro Ala Cys Leu Thr Trp Ile Tyr His 
225                 230                 235                 240 


Ser His Val Asp Ala Pro Arg Asp Ile Ala Thr Gly Leu Ile Gly Pro 
                245                 250                 255     


Leu Ile Thr Cys Lys Arg Gly Ala Leu Asp Gly Asn Ser Pro Pro Gln 
            260                 265                 270         


Arg Gln Asp Val Asp His Asp Phe Phe Leu Leu Phe Ser Val Val Asp 
        275                 280                 285             


Glu Asn Leu Ser Trp His Leu Asn Glu Asn Ile Ala Thr Tyr Cys Ser 
    290                 295                 300                 


Asp Pro Ala Ser Val Asp Lys Glu Asp Glu Thr Phe Gln Glu Ser Asn 
305                 310                 315                 320 


Arg Met His Ala Ile Asn Gly Phe Val Phe Gly Asn Leu Pro Glu Leu 
                325                 330                 335     


Asn Met Cys Ala Gln Lys Arg Val Ala Trp His Leu Phe Gly Met Gly 
            340                 345                 350         


Asn Glu Ile Asp Val His Thr Ala Phe Phe His Gly Gln Met Leu Thr 
        355                 360                 365             


Thr Arg Gly His His Thr Asp Val Ala Asn Ile Phe Pro Ala Thr Phe 
    370                 375                 380                 


Val Thr Ala Glu Met Val Pro Trp Glu Pro Gly Thr Trp Leu Ile Ser 
385                 390                 395                 400 


Cys Gln Val Asn Ser His Phe Arg Asp Gly Met Gln Ala Leu Tyr Lys 
                405                 410                 415     


Val Lys Ser Cys Ser Met Ala Pro Pro Val Asp Leu Leu Thr Gly Lys 
            420                 425                 430         


Val Arg Gln Tyr Phe Ile Glu Ala His Glu Ile Gln Trp Asp Tyr Gly 
        435                 440                 445             


Pro Met Gly His Asp Gly Ser Thr Gly Lys Asn Leu Arg Glu Pro Gly 
    450                 455                 460                 


Ser Ile Ser Asp Lys Phe Phe Gln Lys Ser Ser Ser Arg Ile Gly Gly 
465                 470                 475                 480 


Thr Tyr Trp Lys Val Arg Tyr Glu Ala Phe Gln Asp Glu Thr Phe Gln 
                485                 490                 495     


Glu Lys Met His Leu Glu Glu Asp Arg His Leu Gly Ile Leu Gly Pro 
            500                 505                 510         


Val Ile Arg Ala Glu Val Gly Asp Thr Ile Gln Val Val Phe Tyr Asn 
        515                 520                 525             


Arg Ala Ser Gln Pro Phe Ser Met Gln Pro His Gly Val Phe Tyr Glu 
    530                 535                 540                 


Lys Asp Tyr Glu Gly Thr Val Tyr Asn Asp Gly Ser Ser Tyr Pro Gly 
545                 550                 555                 560 


Leu Val Ala Lys Pro Phe Glu Lys Val Thr Tyr Arg Trp Thr Val Pro 
                565                 570                 575     


Pro His Ala Gly Pro Thr Ala Gln Asp Pro Ala Cys Leu Thr Trp Met 
            580                 585                 590         


Tyr Phe Ser Ala Ala Asp Pro Ile Arg Asp Thr Asn Ser Gly Leu Val 
        595                 600                 605             


Gly Pro Leu Leu Val Cys Arg Ala Gly Ala Leu Gly Ala Asp Gly Lys 
    610                 615                 620                 


Gln Lys Gly Val Asp Lys Glu Phe Phe Leu Leu Phe Thr Val Leu Asp 
625                 630                 635                 640 


Glu Asn Lys Ser Trp Tyr Ser Asn Ala Asn Gln Ala Ala Ala Met Leu 
                645                 650                 655     


Asp Phe Arg Leu Leu Ser Glu Asp Ile Glu Gly Phe Gln Asp Ser Asn 
            660                 665                 670         


Arg Met His Ala Ile Asn Gly Phe Leu Phe Ser Asn Leu Pro Arg Leu 
        675                 680                 685             


Asp Met Cys Lys Gly Asp Thr Val Ala Trp His Leu Leu Gly Leu Gly 
    690                 695                 700                 


Thr Glu Thr Asp Val His Gly Val Met Phe Gln Gly Asn Thr Val Gln 
705                 710                 715                 720 


Leu Gln Gly Met Arg Lys Gly Ala Ala Met Leu Phe Pro His Thr Phe 
                725                 730                 735     


Val Met Ala Ile Met Gln Pro Asp Asn Leu Gly Thr Phe Glu Ile Tyr 
            740                 745                 750         


Cys Gln Ala Gly Ser His Arg Glu Ala Gly Met Arg Ala Ile Tyr Asn 
        755                 760                 765             


Val Ser Gln Cys Pro Gly His Gln Ala Thr Pro Arg Gln Arg Tyr Gln 
    770                 775                 780                 


Ala Ala Arg Ile Tyr Tyr Ile Met Ala Glu Glu Val Glu Trp Asp Tyr 
785                 790                 795                 800 


Cys Pro Asp Arg Ser Trp Glu Arg Glu Trp His Asn Gln Ser Glu Lys 
                805                 810                 815     


Asp Ser Tyr Gly Tyr Ile Phe Leu Ser Asn Lys Asp Gly Leu Leu Gly 
            820                 825                 830         


Ser Arg Tyr Lys Lys Ala Val Phe Arg Glu Tyr Thr Asp Gly Thr Phe 
        835                 840                 845             


Arg Ile Pro Arg Pro Arg Thr Gly Pro Glu Glu His Leu Gly Ile Leu 
    850                 855                 860                 


Gly Pro Leu Ile Lys Gly Glu Val Gly Asp Ile Leu Thr Val Val Phe 
865                 870                 875                 880 


Lys Asn Asn Ala Ser Arg Pro Tyr Ser Val His Ala His Gly Val Leu 
                885                 890                 895     


Glu Ser Thr Thr Val Trp Pro Leu Ala Ala Glu Pro Gly Glu Val Val 
            900                 905                 910         


Thr Tyr Gln Trp Asn Ile Pro Glu Arg Ser Gly Pro Gly Pro Asn Asp 
        915                 920                 925             


Ser Ala Cys Val Ser Trp Ile Tyr Tyr Ser Ala Val Asp Pro Ile Lys 
    930                 935                 940                 


Asp Met Tyr Ser Gly Leu Val Gly Pro Leu Ala Ile Cys Gln Lys Gly 
945                 950                 955                 960 


Ile Leu Glu Pro His Gly Gly Arg Ser Asp Met Asp Arg Glu Phe Ala 
                965                 970                 975     


Leu Leu Phe Leu Ile Phe Asp Glu Asn Lys Ser Trp Tyr Leu Glu Glu 
            980                 985                 990         


Asn Val Ala Thr His Gly Ser Gln  Asp Pro Gly Ser Ile  Asn Leu Gln 
        995                 1000                 1005             


Asp Glu  Thr Phe Leu Glu Ser  Asn Lys Met His Ala  Ile Asn Gly 
    1010                 1015                 1020             


Lys Leu  Tyr Ala Asn Leu Arg  Gly Leu Thr Met Tyr  Gln Gly Glu 
    1025                 1030                 1035             


Arg Val  Ala Trp Tyr Met Leu  Ala Met Gly Gln Asp  Val Asp Leu 
    1040                 1045                 1050             


His Thr  Ile His Phe His Ala  Glu Ser Phe Leu Tyr  Arg Asn Gly 
    1055                 1060                 1065             


Glu Asn  Tyr Arg Ala Asp Val  Val Asp Leu Phe Pro  Gly Thr Phe 
    1070                 1075                 1080             


Glu Val  Val Glu Met Val Ala  Ser Asn Pro Gly Thr  Trp Leu Met 
    1085                 1090                 1095             


His Cys  His Val Thr Asp His  Val His Ala Gly Met  Glu Thr Leu 
    1100                 1105                 1110             


Phe Thr  Val Phe Ser Arg Thr  Glu His Leu Ser Pro  Leu Thr Val 
    1115                 1120                 1125             


Ile Thr  Lys Glu Thr Glu Lys  Ala Val Pro Pro Arg  Asp Ile Glu 
    1130                 1135                 1140             


Glu Gly  Asn Val Lys Met Leu  Gly Met Gln Ile Pro  Ile Lys Asn 
    1145                 1150                 1155             


Val Glu  Met Leu Ala Ser Val  Leu Val Ala Ile Ser  Val Thr Leu 
    1160                 1165                 1170             


Leu Leu  Val Val Leu Ala Leu  Gly Gly Val Val Trp  Tyr Gln His 
    1175                 1180                 1185             


Arg Gln  Arg Lys Leu Arg Arg  Asn Arg Arg Ser Ile  Leu Asp Asp 
    1190                 1195                 1200             


Ser Phe  Lys Leu Leu Ser Phe  Lys Gln 
    1205                 1210         


<210>  5785
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  5785

Met Ala Ser Gly Ser Asn Trp Leu Ser Gly Val Asn Val Val Leu Val 
1               5                   10                  15      


Met Ala Tyr Gly Ser Leu Asp Leu Lys Glu Glu Ile Asp Ile Arg Leu 
            20                  25                  30          


Ser Arg Val Gln Asp Ile Lys Tyr Glu Pro Gln Leu Leu Ala Asp Asp 
        35                  40                  45              


Asp Ala Arg Leu Leu Gln Leu Glu Thr Gln Gly Asn Gln Lys Ile Pro 
    50                  55                  60                  


Phe His Ser Glu Gly Arg His Pro Arg Ser Leu Met Gly Lys Asn Phe 
65                  70                  75                  80  


Arg Ser Tyr Leu Leu Asp Leu Arg Asn Thr Ser Thr Pro Phe Lys Gly 
                85                  90                  95      


Val Arg Lys Ala Leu Ile Asp Thr Leu Leu Asp Gly Tyr Glu Thr Ala 
            100                 105                 110         


Arg Tyr Gly Thr Gly Val Phe Gly Gln Asn Glu Tyr Leu Arg Tyr Gln 
        115                 120                 125             


Glu Ala Leu Ser Glu Leu Ala Thr Ala Val Lys Ala Arg Ile Gly Ser 
    130                 135                 140                 


Ser Gln Arg His His Gln Ser Ala Ala Lys Asp Leu Thr Gln Ser Pro 
145                 150                 155                 160 


Glu Val Ser Pro Thr Thr Ile Gln Val Thr Tyr Leu Pro Ser Ser Gln 
                165                 170                 175     


Lys Ser Lys Arg Ala Lys His Phe Leu Glu Leu Lys Ser Phe Lys Asp 
            180                 185                 190         


Asn Tyr Asn Thr Leu Glu Ser Thr Leu 
        195                 200     


<210>  5786
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  5786

Met Asp Gly Ser Gly Glu Gln Pro Arg Gly Gly Gly Pro Thr Ser Ser 
1               5                   10                  15      


Glu Gln Ile Met Lys Thr Gly Ala Leu Leu Leu Gln Gly Phe Ile Gln 
            20                  25                  30          


Asp Arg Ala Gly Arg Met Gly Gly Glu Ala Pro Glu Leu Ala Leu Asp 
        35                  40                  45              


Pro Val Pro Gln Asp Ala Ser Thr Lys Lys Leu Ser Glu Cys Leu Lys 
    50                  55                  60                  


Arg Ile Gly Asp Glu Leu Asp Ser Asn Met Glu Leu Gln Arg Met Ile 
65                  70                  75                  80  


Ala Ala Val Asp Thr Asp Ser Pro Arg Glu Val Phe Phe Arg Val Ala 
                85                  90                  95      


Ala Asp Met Phe Ser Asp Gly Asn Phe Asn Trp Gly Arg Val Val Ala 
            100                 105                 110         


Leu Phe Tyr Phe Ala Ser Lys Leu Val Leu Lys Ala Leu Cys Thr Lys 
        115                 120                 125             


Val Pro Glu Leu Ile Arg Thr Ile Met Gly Trp Thr Leu Asp Phe Leu 
    130                 135                 140                 


Arg Glu Arg Leu Leu Gly Trp Ile Gln Asp Gln Gly Gly Trp Asp Gly 
145                 150                 155                 160 


Leu Leu Ser Tyr Phe Gly Thr Pro Thr Trp Gln Thr Val Thr Ile Phe 
                165                 170                 175     


Val Ala Gly Val Leu Thr Ala Ser Leu Thr Ile Trp Lys Lys Met Gly 
            180                 185                 190         


<210>  5787
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  5787

Met Asp Gly Ser Gly Glu Gln Pro Arg Gly Gly Gly Pro Thr Ser Ser 
1               5                   10                  15      


Glu Gln Ile Met Lys Thr Gly Ala Leu Leu Leu Gln Gly Met Ile Ala 
            20                  25                  30          


Ala Val Asp Thr Asp Ser Pro Arg Glu Val Phe Phe Arg Val Ala Ala 
        35                  40                  45              


Asp Met Phe Ser Asp Gly Asn Phe Asn Trp Gly Arg Val Val Ala Leu 
    50                  55                  60                  


Phe Tyr Phe Ala Ser Lys Leu Val Leu Lys Ala Leu Cys Thr Lys Val 
65                  70                  75                  80  


Pro Glu Leu Ile Arg Thr Ile Met Gly Trp Thr Leu Asp Phe Leu Arg 
                85                  90                  95      


Glu Arg Leu Leu Gly Trp Ile Gln Asp Gln Gly Gly Trp Asp Gly Leu 
            100                 105                 110         


Leu Ser Tyr Phe Gly Thr Pro Thr Trp Gln Thr Val Thr Ile Phe Val 
        115                 120                 125             


Ala Gly Val Leu Thr Ala Ser Leu Thr Ile Trp Lys Lys Met Gly 
    130                 135                 140             


<210>  5788
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  5788

Met Asp Gly Ser Gly Glu Gln Pro Arg Gly Gly Gly Pro Thr Ser Ser 
1               5                   10                  15      


Glu Gln Ile Met Lys Thr Gly Ala Leu Leu Leu Gln Gly Phe Ile Gln 
            20                  25                  30          


Asp Arg Ala Gly Arg Met Gly Gly Glu Ala Pro Glu Leu Ala Leu Asp 
        35                  40                  45              


Pro Val Pro Gln Asp Ala Ser Thr Lys Lys Leu Ser Glu Cys Leu Lys 
    50                  55                  60                  


Arg Ile Gly Asp Glu Leu Asp Ser Asn Met Glu Leu Gln Arg Met Ile 
65                  70                  75                  80  


Ala Ala Val Asp Thr Asp Ser Pro Arg Glu Val Phe Phe Arg Val Ala 
                85                  90                  95      


Ala Asp Met Phe Ser Asp Gly Asn Phe Asn Trp Gly Arg Val Val Ala 
            100                 105                 110         


Leu Phe Tyr Phe Ala Ser Lys Leu Val Leu Lys Ala Leu Cys Thr Lys 
        115                 120                 125             


Val Pro Glu Leu Ile Arg Thr Ile Met Gly Trp Thr Leu Asp Phe Leu 
    130                 135                 140                 


Arg Glu Arg Leu Leu Gly Trp Ile Gln Asp Gln Gly Gly Trp Thr Val 
145                 150                 155                 160 


Thr Ile Phe Val Ala Gly Val Leu Thr Ala Ser Leu Thr Ile Trp Lys 
                165                 170                 175     


Lys Met Gly 
            


<210>  5789
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  5789

Met Asp Gly Ser Gly Glu Gln Pro Arg Gly Gly Gly Pro Thr Ser Ser 
1               5                   10                  15      


Glu Gln Ile Met Lys Thr Gly Ala Leu Leu Leu Gln Gly Phe Ile Gln 
            20                  25                  30          


Asp Arg Ala Gly Arg Met Gly Gly Glu Ala Pro Glu Leu Ala Leu Asp 
        35                  40                  45              


Pro Val Pro Gln Asp Ala Ser Thr Lys Lys Leu Ser Glu Cys Leu Lys 
    50                  55                  60                  


Arg Ile Gly Asp Glu Leu Asp Ser Asn Met Glu Leu Gln Arg Met Ile 
65                  70                  75                  80  


Ala Ala Val Asp Thr Asp Ser Pro Arg Glu Val Phe Phe Arg Val Ala 
                85                  90                  95      


Ala Asp Met Phe Ser Asp Gly Asn Phe Asn Trp Gly Arg Val Val Ala 
            100                 105                 110         


Leu Phe Tyr Phe Ala Ser Lys Leu Val Leu Lys Ala Leu Cys Thr Lys 
        115                 120                 125             


Val Pro Glu Leu Ile Arg Thr Ile Met Gly Trp Thr Leu Asp Phe Leu 
    130                 135                 140                 


Arg Glu Arg Leu Leu Gly Trp Ile Gln Asp Gln Gly Gly Trp Thr Val 
145                 150                 155                 160 


Thr Ile Phe Val Ala Gly Val Leu Thr Ala Ser Leu Thr Ile Trp Lys 
                165                 170                 175     


Lys Met Gly 
            


<210>  5790
<211>  905
<212>  PRT
<213>  Homo sapiens

<400>  5790

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
            20                  25                  30          


Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
        35                  40                  45              


Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg Met Pro 
    50                  55                  60                  


Gly Val Thr Pro Lys Gln Ser Asp Thr Tyr Phe Cys Met Ser Met Arg 
65                  70                  75                  80  


Ile Pro Val Asp Glu Glu Ala Phe Val Ile Asp Phe Lys Pro Arg Ala 
                85                  90                  95      


Ser Met Asp Thr Val His His Met Leu Leu Phe Gly Cys Asn Met Pro 
            100                 105                 110         


Ser Ser Thr Gly Ser Tyr Trp Phe Cys Asp Glu Gly Thr Cys Thr Asp 
        115                 120                 125             


Lys Ala Asn Ile Leu Tyr Ala Trp Ala Arg Asn Ala Pro Pro Thr Arg 
    130                 135                 140                 


Leu Pro Lys Gly Val Gly Phe Arg Val Gly Gly Glu Thr Gly Ser Lys 
145                 150                 155                 160 


Tyr Phe Val Leu Gln Val His Tyr Gly Asp Ile Ser Ala Phe Arg Asp 
                165                 170                 175     


Asn Asn Lys Asp Cys Ser Gly Val Ser Leu His Leu Thr Arg Leu Pro 
            180                 185                 190         


Gln Pro Leu Ile Ala Gly Met Tyr Leu Met Met Ser Val Asp Thr Val 
        195                 200                 205             


Ile Pro Ala Gly Glu Lys Val Val Asn Ser Asp Ile Ser Cys His Tyr 
    210                 215                 220                 


Lys Asn Tyr Pro Met His Val Phe Ala Tyr Arg Val His Thr His His 
225                 230                 235                 240 


Leu Gly Lys Val Val Ser Gly Tyr Arg Val Arg Asn Gly Gln Trp Thr 
                245                 250                 255     


Leu Ile Gly Arg Gln Ser Pro Gln Leu Pro Gln Ala Phe Tyr Pro Val 
            260                 265                 270         


Gly His Pro Val Asp Val Ser Phe Gly Asp Leu Leu Ala Ala Arg Cys 
        275                 280                 285             


Val Phe Thr Gly Glu Gly Arg Thr Glu Ala Thr His Ile Gly Gly Thr 
    290                 295                 300                 


Ser Ser Asp Glu Met Cys Asn Leu Tyr Ile Met Tyr Tyr Met Glu Ala 
305                 310                 315                 320 


Lys His Ala Val Ser Phe Met Thr Cys Thr Gln Asn Val Ala Pro Asp 
                325                 330                 335     


Met Phe Arg Thr Ile Pro Pro Glu Ala Asn Ile Pro Ile Pro Val Lys 
            340                 345                 350         


Ser Asp Met Val Met Met His Glu His His Lys Glu Thr Glu Tyr Lys 
        355                 360                 365             


Asp Lys Ile Pro Leu Leu Gln Gln Pro Lys Arg Glu Glu Glu Glu Val 
    370                 375                 380                 


Leu Asp Gln Gly Asp Phe Tyr Ser Leu Leu Ser Lys Leu Leu Gly Glu 
385                 390                 395                 400 


Arg Glu Asp Val Val His Val His Lys Tyr Asn Pro Thr Glu Lys Ala 
                405                 410                 415     


Glu Ser Glu Ser Asp Leu Val Ala Glu Ile Ala Asn Val Val Gln Lys 
            420                 425                 430         


Lys Asp Leu Gly Arg Ser Asp Ala Arg Glu Gly Ala Glu His Glu Arg 
        435                 440                 445             


Gly Asn Ala Ile Leu Val Arg Asp Arg Ile His Lys Phe His Arg Leu 
    450                 455                 460                 


Val Ser Thr Leu Arg Pro Pro Glu Ser Arg Val Phe Ser Leu Gln Gln 
465                 470                 475                 480 


Pro Pro Pro Gly Glu Gly Thr Trp Glu Pro Glu His Thr Gly Asp Phe 
                485                 490                 495     


His Met Glu Glu Ala Leu Asp Trp Pro Gly Val Tyr Leu Leu Pro Gly 
            500                 505                 510         


Gln Val Ser Gly Val Ala Leu Asp Pro Lys Asn Asn Leu Val Ile Phe 
        515                 520                 525             


His Arg Gly Asp His Val Trp Asp Gly Asn Ser Phe Asp Ser Lys Phe 
    530                 535                 540                 


Val Tyr Gln Gln Ile Gly Leu Gly Pro Ile Glu Glu Asp Thr Ile Leu 
545                 550                 555                 560 


Val Ile Asp Pro Asn Asn Ala Ala Val Leu Gln Ser Ser Gly Lys Asn 
                565                 570                 575     


Leu Phe Tyr Leu Pro His Gly Leu Ser Ile Asp Lys Asp Gly Asn Tyr 
            580                 585                 590         


Trp Val Thr Asp Val Ala Leu His Gln Val Phe Lys Leu Asp Pro Asn 
        595                 600                 605             


Asn Lys Glu Gly Pro Val Leu Ile Leu Gly Arg Ser Met Gln Pro Gly 
    610                 615                 620                 


Ser Asp Gln Asn His Phe Cys Gln Pro Thr Asp Val Ala Val Asp Pro 
625                 630                 635                 640 


Gly Thr Gly Ala Ile Tyr Val Ser Asp Gly Tyr Cys Asn Ser Arg Ile 
                645                 650                 655     


Val Gln Phe Ser Pro Ser Gly Lys Phe Ile Thr Gln Trp Gly Glu Glu 
            660                 665                 670         


Ser Ser Gly Ser Ser Pro Leu Pro Gly Gln Phe Thr Val Pro His Ser 
        675                 680                 685             


Leu Ala Leu Val Pro Leu Leu Gly Gln Leu Cys Val Ala Asp Arg Glu 
    690                 695                 700                 


Asn Gly Arg Ile Gln Cys Phe Lys Thr Asp Thr Lys Glu Phe Val Arg 
705                 710                 715                 720 


Glu Ile Lys His Ser Ser Phe Gly Arg Asn Val Phe Ala Ile Ser Tyr 
                725                 730                 735     


Ile Pro Gly Leu Leu Phe Ala Val Asn Gly Lys Pro His Phe Gly Asp 
            740                 745                 750         


Gln Glu Pro Val Gln Gly Phe Val Met Asn Phe Ser Asn Gly Glu Ile 
        755                 760                 765             


Ile Asp Ile Phe Lys Pro Val Arg Lys His Phe Asp Met Pro His Asp 
    770                 775                 780                 


Ile Val Ala Ser Glu Asp Gly Thr Val Tyr Ile Gly Asp Ala His Thr 
785                 790                 795                 800 


Asn Thr Val Trp Lys Phe Thr Leu Thr Glu Lys Leu Glu His Arg Ser 
                805                 810                 815     


Val Lys Lys Ala Gly Ile Glu Val Gln Glu Ile Lys Asp Ser Glu His 
            820                 825                 830         


Lys Leu Glu Thr Ser Ser Gly Arg Val Leu Gly Arg Phe Arg Gly Lys 
        835                 840                 845             


Gly Ser Gly Gly Leu Asn Leu Gly Asn Phe Phe Ala Ser Arg Lys Gly 
    850                 855                 860                 


Tyr Ser Arg Lys Gly Phe Asp Arg Leu Ser Thr Glu Gly Ser Asp Gln 
865                 870                 875                 880 


Glu Lys Glu Asp Asp Gly Ser Glu Ser Glu Glu Glu Tyr Ser Ala Pro 
                885                 890                 895     


Leu Pro Ala Leu Ala Pro Ser Ser Ser 
            900                 905 


<210>  5791
<211>  618
<212>  PRT
<213>  Homo sapiens

<400>  5791

Met Arg Arg Asp Val Arg Ile Leu Leu Leu Gly Glu Ala Gln Val Gly 
1               5                   10                  15      


Lys Thr Ser Leu Ile Leu Ser Leu Val Gly Glu Glu Phe Pro Glu Glu 
            20                  25                  30          


Val Pro Pro Arg Ala Glu Glu Ile Thr Ile Pro Ala Asp Val Thr Pro 
        35                  40                  45              


Glu Lys Val Pro Thr His Ile Val Asp Tyr Ser Glu Ala Glu Gln Thr 
    50                  55                  60                  


Asp Glu Glu Leu Arg Glu Glu Ile His Lys Ala Asn Val Val Cys Val 
65                  70                  75                  80  


Val Tyr Asp Val Ser Glu Glu Ala Thr Ile Glu Lys Ile Arg Thr Lys 
                85                  90                  95      


Trp Ile Pro Leu Val Asn Gly Gly Thr Thr Gln Gly Pro Arg Val Pro 
            100                 105                 110         


Ile Ile Leu Val Gly Asn Lys Ser Asp Leu Arg Ser Gly Ser Ser Met 
        115                 120                 125             


Glu Ala Val Leu Pro Ile Met Ser Gln Phe Pro Glu Ile Glu Thr Cys 
    130                 135                 140                 


Val Glu Cys Ser Ala Lys Asn Leu Arg Asn Ile Ser Glu Leu Phe Tyr 
145                 150                 155                 160 


Tyr Ala Gln Lys Ala Val Leu His Pro Thr Ala Pro Leu Tyr Asp Pro 
                165                 170                 175     


Glu Ala Lys Gln Leu Arg Pro Ala Cys Ala Gln Ala Leu Thr Arg Ile 
            180                 185                 190         


Phe Arg Leu Ser Asp Gln Asp Leu Asp Gln Ala Leu Ser Asp Glu Glu 
        195                 200                 205             


Leu Asn Ala Phe Gln Lys Ser Cys Phe Gly His Pro Leu Ala Pro Gln 
    210                 215                 220                 


Ala Leu Glu Asp Val Lys Thr Val Val Cys Arg Asn Val Ala Gly Gly 
225                 230                 235                 240 


Val Arg Glu Asp Arg Leu Thr Leu Asp Gly Phe Leu Phe Leu Asn Thr 
                245                 250                 255     


Leu Phe Ile Gln Arg Gly Arg His Glu Thr Thr Trp Thr Ile Leu Arg 
            260                 265                 270         


Arg Phe Gly Tyr Ser Asp Ala Leu Glu Leu Thr Ala Asp Tyr Leu Ser 
        275                 280                 285             


Pro Leu Ile His Val Pro Pro Gly Cys Ser Thr Glu Leu Asn His Leu 
    290                 295                 300                 


Gly Tyr Gln Phe Val Gln Arg Val Phe Glu Lys His Asp Gln Asp Arg 
305                 310                 315                 320 


Asp Gly Ala Leu Ser Pro Val Glu Leu Gln Ser Leu Phe Ser Val Phe 
                325                 330                 335     


Pro Ala Ala Pro Trp Gly Pro Glu Leu Pro Arg Thr Val Arg Thr Glu 
            340                 345                 350         


Ala Gly Arg Leu Pro Leu His Gly Tyr Leu Cys Gln Trp Thr Leu Val 
        355                 360                 365             


Thr Tyr Leu Asp Val Arg Ser Cys Leu Gly His Leu Gly Tyr Leu Gly 
    370                 375                 380                 


Tyr Pro Thr Leu Cys Glu Gln Asp Gln Ala His Ala Ile Thr Val Thr 
385                 390                 395                 400 


Arg Glu Lys Arg Leu Asp Gln Glu Lys Gly Gln Thr Gln Arg Ser Val 
                405                 410                 415     


Leu Leu Cys Lys Val Val Gly Ala Arg Gly Val Gly Lys Ser Ala Phe 
            420                 425                 430         


Leu Gln Ala Phe Leu Gly Arg Gly Leu Gly His Gln Asp Thr Arg Glu 
        435                 440                 445             


Gln Pro Pro Gly Tyr Ala Ile Asp Thr Val Gln Val Asn Gly Gln Glu 
    450                 455                 460                 


Lys Tyr Leu Ile Leu Cys Glu Val Gly Thr Asp Gly Leu Leu Ala Thr 
465                 470                 475                 480 


Ser Leu Asp Ala Thr Cys Asp Val Ala Cys Leu Met Phe Asp Gly Ser 
                485                 490                 495     


Asp Pro Lys Ser Phe Ala His Cys Ala Ser Val Tyr Lys His His Tyr 
            500                 505                 510         


Met Asp Gly Gln Thr Pro Cys Leu Phe Val Ser Ser Lys Ala Asp Leu 
        515                 520                 525             


Pro Glu Gly Val Ala Val Ser Gly Pro Ser Pro Ala Glu Phe Cys Arg 
    530                 535                 540                 


Lys His Arg Leu Pro Ala Pro Val Pro Phe Ser Cys Ala Gly Pro Ala 
545                 550                 555                 560 


Glu Pro Ser Thr Thr Ile Phe Thr Gln Leu Ala Thr Met Ala Ala Phe 
                565                 570                 575     


Pro His Leu Val His Ala Glu Leu His Pro Ser Ser Phe Trp Leu Arg 
            580                 585                 590         


Gly Leu Leu Gly Val Val Gly Ala Ala Val Ala Ala Val Leu Ser Phe 
        595                 600                 605             


Ser Leu Tyr Arg Val Leu Val Lys Ser Gln 
    610                 615             


<210>  5792
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  5792

Met Phe Phe Thr Ile Ser Arg Lys Asn Met Ser Gln Lys Leu Ser Leu 
1               5                   10                  15      


Leu Leu Leu Val Phe Gly Leu Ile Trp Gly Leu Met Leu Leu His Tyr 
            20                  25                  30          


Thr Phe Gln Gln Pro Arg His Gln Ser Ser Val Lys Leu Arg Glu Gln 
        35                  40                  45              


Ile Leu Asp Leu Ser Lys Arg Tyr Val Lys Ala Leu Ala Glu Glu Asn 
    50                  55                  60                  


Lys Asn Thr Val Asp Val Glu Asn Gly Ala Ser Met Ala Gly Tyr Ala 
65                  70                  75                  80  


Asp Leu Lys Arg Thr Ile Ala Val Leu Leu Asp Asp Ile Leu Gln Arg 
                85                  90                  95      


Leu Val Lys Leu Glu Asn Lys Val Asp Tyr Ile Val Val Asn Gly Ser 
            100                 105                 110         


Ala Ala Asn Thr Thr Asn Gly Thr Ser Gly Asn Leu Val Pro Val Thr 
        115                 120                 125             


Thr Asn Lys Arg Thr Asn Val Ser Gly Ser Ile Arg 
    130                 135                 140 


<210>  5793
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  5793

Met Glu Gly Ala Pro Pro Gly Ser Leu Ala Leu Arg Leu Leu Leu Phe 
1               5                   10                  15      


Val Ala Leu Pro Ala Ser Gly Trp Leu Thr Thr Gly Ala Pro Glu Pro 
            20                  25                  30          


Pro Pro Leu Ser Gly Ala Pro Gln Asp Gly Ile Arg Ile Asn Val Thr 
        35                  40                  45              


Thr Leu Lys Asp Asp Gly Asp Ile Ser Lys Gln Gln Val Val Leu Asn 
    50                  55                  60                  


Ile Thr Tyr Glu Ser Gly Gln Val Tyr Val Asn Asp Leu Pro Val Asn 
65                  70                  75                  80  


Ser Gly Val Thr Arg Ile Ser Cys Gln Thr Leu Ile Val Lys Asn Glu 
                85                  90                  95      


Asn Leu Glu Asn Leu Glu Glu Lys Glu Tyr Phe Gly Ile Val Ser Val 
            100                 105                 110         


Arg Ile Leu Val His Glu Trp Pro Met Thr Ser Gly Ser Ser Leu Gln 
        115                 120                 125             


Leu Ile Val Ile Gln Glu Glu Val Val Glu Ile Asp Gly Lys Gln Val 
    130                 135                 140                 


Gln Gln Lys Asp Val Thr Glu Ile Asp Ile Leu Val Lys Asn Arg Gly 
145                 150                 155                 160 


Val Leu Arg His Ser Asn Tyr Thr Leu Pro Leu Glu Glu Ser Met Leu 
                165                 170                 175     


Tyr Ser Ile Ser Arg Asp Ser Asp Ile Leu Phe Thr Leu Pro Asn Leu 
            180                 185                 190         


Ser Lys Lys Glu Ser Val Ser Ser Leu Gln Thr Thr Ser Gln Tyr Leu 
        195                 200                 205             


Ile Arg Asn Val Glu Thr Thr Val Asp Glu Asp Val Leu Pro Gly Lys 
    210                 215                 220                 


Leu Pro Glu Thr Pro Leu Arg Ala Glu Pro Pro Ser Ser Tyr Lys Val 
225                 230                 235                 240 


Met Cys Gln Trp Met Glu Lys Phe Arg Lys Asp Leu Cys Arg Phe Trp 
                245                 250                 255     


Ser Asn Val Phe Pro Val Phe Phe Gln Phe Leu Asn Ile Met Val Val 
            260                 265                 270         


Gly Ile Thr Gly Ala Ala Val Val Ile Thr Ile Leu Lys Val Phe Phe 
        275                 280                 285             


Pro Val Ser Glu Tyr Lys Gly Ile Leu Gln Leu Asp Lys Val Asp Val 
    290                 295                 300                 


Ile Pro Val Thr Ala Ile Asn Leu Tyr Pro Asp Gly Pro Glu Lys Arg 
305                 310                 315                 320 


Ala Glu Asn Leu Glu Asp Lys Thr Cys Ile 
                325                 330 


<210>  5794
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  5794

Met Gly Ser Arg Lys Cys Gly Gly Cys Leu Ser Cys Leu Leu Ile Pro 
1               5                   10                  15      


Leu Ala Leu Trp Ser Ile Ile Val Asn Ile Leu Leu Tyr Phe Pro Asn 
            20                  25                  30          


Gly Gln Thr Ser Tyr Ala Ser Ser Asn Lys Leu Thr Asn Tyr Val Trp 
        35                  40                  45              


Tyr Phe Glu Gly Ile Cys Phe Ser Gly Ile Met Met Leu Ile Val Thr 
    50                  55                  60                  


Thr Val Leu Leu Val Leu Glu Asn Asn Asn Asn Tyr Lys Cys Cys Gln 
65                  70                  75                  80  


Ser Glu Asn Cys Ser Lys Lys Tyr Val Thr Leu Leu Ser Ile Ile Phe 
                85                  90                  95      


Ser Ser Leu Gly Ile Ala Phe Ser Gly Tyr Cys Leu Val Ile Ser Ala 
            100                 105                 110         


Leu Gly Leu Val Gln Gly Pro Tyr Cys Arg Thr Leu Asp Gly Trp Glu 
        115                 120                 125             


Tyr Ala Phe Glu Gly Thr Ala Gly Arg Phe Leu Thr Asp Ser Ser Ile 
    130                 135                 140                 


Trp Ile Gln Cys Leu Glu Pro Ala His Val Val Glu Trp Asn Ile Ile 
145                 150                 155                 160 


Leu Phe Ser Ile Leu Ile Thr Leu Ser Gly Leu Gln Val Ile Ile Cys 
                165                 170                 175     


Leu Ile Arg Val Val Met Gln Leu Ser Lys Ile Leu Cys Gly Ser Tyr 
            180                 185                 190         


Ser Val Ile Phe Gln Pro Gly Ile Ile 
        195                 200     


<210>  5795
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  5795

Met Ala Asn Phe Lys Gly His Ala Leu Pro Gly Ser Phe Phe Leu Ile 
1               5                   10                  15      


Ile Gly Leu Cys Trp Ser Val Lys Tyr Pro Leu Lys Tyr Phe Ser His 
            20                  25                  30          


Thr Arg Lys Asn Ser Pro Leu His Tyr Tyr Gln Arg Leu Glu Ile Val 
        35                  40                  45              


Glu Ala Ala Ile Arg Thr Leu Phe Ser Val Thr Gly Ile Leu Ala Glu 
    50                  55                  60                  


Gln Phe Val Pro Asp Gly Pro His Leu His Leu Tyr His Glu Asn His 
65                  70                  75                  80  


Trp Ile Lys Leu Met Asn Trp Gln His Ser Thr Met Tyr Leu Phe Phe 
                85                  90                  95      


Ala Val Ser Gly Ile Val Asp Met Leu Thr Tyr Leu Val Ser His Val 
            100                 105                 110         


Pro Leu Gly Val Asp Arg Leu Val Met Ala Val Ala Val Phe Met Glu 
        115                 120                 125             


Gly Phe Leu Phe Tyr Tyr His Val His Asn Arg Pro Pro Leu Asp Gln 
    130                 135                 140                 


His Ile His Ser Leu Leu Leu Tyr Ala Leu Phe Gly Gly Cys Val Ser 
145                 150                 155                 160 


Ile Ser Leu Glu Val Ile Phe Arg Asp His Ile Val Leu Glu Leu Phe 
                165                 170                 175     


Arg Thr Ser Leu Ile Ile Leu Gln Gly Thr Trp Phe Trp Gln Ile Gly 
            180                 185                 190         


Phe Val Leu Phe Pro Pro Phe Gly Thr Pro Glu Trp Asp Gln Lys Asp 
        195                 200                 205             


Asp Ala Asn Leu Met Phe Ile Thr Met Cys Phe Cys Trp His Tyr Leu 
    210                 215                 220                 


Ala Ala Leu Ser Ile Val Ala Val Asn Tyr Ser Leu Val Tyr Cys Leu 
225                 230                 235                 240 


Leu Thr Arg Met Lys Arg His Gly Arg Gly Glu Ile Ile Gly Ile Gln 
                245                 250                 255     


Lys Leu Asn Ser Asp Asp Thr Tyr Gln Thr Ala Leu Leu Ser Gly Ser 
            260                 265                 270         


Asp Glu Glu 
        275 


<210>  5796
<211>  506
<212>  PRT
<213>  Homo sapiens

<400>  5796

Met Leu Lys Pro Leu Trp Lys Ala Ala Val Ala Pro Thr Trp Pro Cys 
1               5                   10                  15      


Ser Met Pro Pro Arg Arg Pro Trp Asp Arg Glu Ala Gly Thr Leu Gln 
            20                  25                  30          


Val Leu Gly Ala Leu Ala Val Leu Trp Leu Gly Ser Val Ala Leu Ile 
        35                  40                  45              


Cys Leu Leu Trp Gln Val Pro Arg Pro Pro Thr Trp Gly Gln Val Gln 
    50                  55                  60                  


Pro Lys Asp Val Pro Arg Ser Trp Glu His Gly Ser Ser Pro Ala Trp 
65                  70                  75                  80  


Glu Pro Leu Glu Ala Glu Ala Arg Gln Gln Arg Asp Ser Cys Gln Leu 
                85                  90                  95      


Val Leu Val Glu Ser Ile Pro Gln Asp Leu Pro Ser Ala Ala Gly Ser 
            100                 105                 110         


Pro Ser Ala Gln Pro Leu Gly Gln Ala Trp Leu Gln Leu Leu Asp Thr 
        115                 120                 125             


Ala Gln Glu Ser Val His Val Ala Ser Tyr Tyr Trp Ser Leu Thr Gly 
    130                 135                 140                 


Pro Asp Ile Gly Val Asn Asp Ser Ser Ser Gln Leu Gly Glu Ala Leu 
145                 150                 155                 160 


Leu Gln Lys Leu Gln Gln Leu Leu Gly Arg Asn Ile Ser Leu Ala Val 
                165                 170                 175     


Ala Thr Ser Ser Pro Thr Leu Ala Arg Thr Ser Thr Asp Leu Gln Val 
            180                 185                 190         


Leu Ala Ala Arg Gly Ala His Val Arg Gln Val Pro Met Gly Arg Leu 
        195                 200                 205             


Thr Arg Gly Val Leu His Ser Lys Phe Trp Val Val Asp Gly Arg His 
    210                 215                 220                 


Ile Tyr Met Gly Ser Ala Asn Met Asp Trp Arg Ser Leu Thr Gln Val 
225                 230                 235                 240 


Lys Glu Leu Gly Ala Val Ile Tyr Asn Cys Ser His Leu Ala Gln Asp 
                245                 250                 255     


Leu Glu Lys Thr Phe Gln Thr Tyr Trp Val Leu Gly Val Pro Lys Ala 
            260                 265                 270         


Val Leu Pro Lys Thr Trp Pro Gln Asn Phe Ser Ser His Phe Asn Arg 
        275                 280                 285             


Phe Gln Pro Phe His Gly Leu Phe Asp Gly Val Pro Thr Thr Ala Tyr 
    290                 295                 300                 


Phe Ser Ala Ser Pro Pro Ala Leu Cys Pro Gln Gly Arg Thr Arg Asp 
305                 310                 315                 320 


Leu Glu Ala Leu Leu Ala Val Met Gly Ser Ala Gln Glu Phe Ile Tyr 
                325                 330                 335     


Ala Ser Val Met Glu Tyr Phe Pro Thr Thr Arg Phe Ser His Pro Pro 
            340                 345                 350         


Arg Tyr Trp Pro Val Leu Asp Asn Ala Leu Arg Ala Ala Ala Phe Gly 
        355                 360                 365             


Lys Gly Val Arg Val Arg Leu Leu Val Gly Cys Gly Leu Asn Thr Asp 
    370                 375                 380                 


Pro Thr Met Phe Pro Tyr Leu Arg Ser Leu Gln Ala Leu Ser Asn Pro 
385                 390                 395                 400 


Ala Ala Asn Val Ser Val Asp Val Lys Val Phe Ile Val Pro Val Gly 
                405                 410                 415     


Asn His Ser Asn Ile Pro Phe Ser Arg Val Asn His Ser Lys Phe Met 
            420                 425                 430         


Val Thr Glu Lys Ala Ala Tyr Ile Gly Thr Ser Asn Trp Ser Glu Asp 
        435                 440                 445             


Tyr Phe Ser Ser Thr Ala Gly Val Gly Leu Val Val Thr Gln Ser Pro 
    450                 455                 460                 


Gly Ala Gln Pro Ala Gly Ala Thr Val Gln Glu Gln Leu Arg Gln Leu 
465                 470                 475                 480 


Phe Glu Arg Asp Trp Ser Ser Arg Tyr Ala Val Gly Leu Asp Gly Gln 
                485                 490                 495     


Ala Pro Gly Gln Asp Cys Val Trp Gln Gly 
            500                 505     


<210>  5797
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  5797

Met Pro Val Gln Leu Ser Glu His Pro Glu Trp Asn Glu Ser Met His 
1               5                   10                  15      


Ser Leu Arg Ile Ser Val Gly Gly Leu Pro Val Leu Ala Ser Met Thr 
            20                  25                  30          


Lys Ala Ala Asp Pro Arg Phe Arg Pro Arg Trp Lys Val Ile Leu Thr 
        35                  40                  45              


Phe Phe Val Gly Ala Ala Ile Leu Trp Leu Leu Cys Ser His Arg Pro 
    50                  55                  60                  


Ala Pro Gly Arg Pro Pro Thr His Asn Ala His Asn Trp Arg Leu Gly 
65                  70                  75                  80  


Gln Ala Pro Ala Asn Trp Tyr Asn Asp Thr Tyr Pro Leu Ser Pro Pro 
                85                  90                  95      


Gln Arg Thr Pro Ala Gly Ile Arg Tyr Arg Ile Ala Val Ile Ala Asp 
            100                 105                 110         


Leu Asp Thr Glu Ser Arg Ala Gln Glu Glu Asn Thr Trp Phe Ser Tyr 
        115                 120                 125             


Leu Lys Lys Gly Tyr Leu Thr Leu Ser Asp Ser Gly Asp Lys Val Ala 
    130                 135                 140                 


Val Glu Trp Asp Lys Asp His Gly Val Leu Glu Ser His Leu Ala Glu 
145                 150                 155                 160 


Lys Gly Arg Gly Met Glu Leu Ser Asp Leu Ile Val Phe Asn Gly Lys 
                165                 170                 175     


Leu Tyr Ser Val Asp Asp Arg Thr Gly Val Val Tyr Gln Ile Glu Gly 
            180                 185                 190         


Ser Lys Ala Val Pro Trp Val Ile Leu Ser Asp Gly Asp Gly Thr Val 
        195                 200                 205             


Glu Lys Gly Phe Lys Ala Glu Trp Leu Ala Val Lys Asp Glu Arg Leu 
    210                 215                 220                 


Tyr Val Gly Gly Leu Gly Lys Glu Trp Thr Thr Thr Thr Gly Asp Val 
225                 230                 235                 240 


Val Asn Glu Asn Pro Glu Trp Val Lys Val Val Gly Tyr Lys Gly Ser 
                245                 250                 255     


Val Asp His Glu Asn Trp Val Ser Asn Tyr Asn Ala Leu Arg Ala Ala 
            260                 265                 270         


Ala Gly Ile Gln Pro Pro Gly Tyr Leu Ile His Glu Ser Ala Cys Trp 
        275                 280                 285             


Ser Asp Thr Leu Gln Arg Trp Phe Phe Leu Pro Arg Arg Ala Ser Gln 
    290                 295                 300                 


Glu Arg Tyr Ser Glu Lys Asp Asp Glu Arg Lys Gly Ala Asn Leu Leu 
305                 310                 315                 320 


Leu Ser Ala Ser Pro Asp Phe Gly Asp Ile Ala Val Ser His Val Gly 
                325                 330                 335     


Ala Val Val Pro Thr His Gly Phe Ser Ser Phe Lys Phe Ile Pro Asn 
            340                 345                 350         


Thr Asp Asp Gln Ile Ile Val Ala Leu Lys Ser Glu Glu Asp Ser Gly 
        355                 360                 365             


Arg Val Ala Ser Tyr Ile Met Ala Phe Thr Leu Asp Gly Arg Phe Leu 
    370                 375                 380                 


Leu Pro Glu Thr Lys Ile Gly Ser Val Lys Tyr Glu Gly Ile Glu Phe 
385                 390                 395                 400 


Ile 
    


<210>  5798
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  5798

Met Ala Thr Thr Ser Thr Thr Gly Ser Thr Leu Leu Gln Pro Leu Ser 
1               5                   10                  15      


Asn Ala Val Gln Leu Pro Ile Asp Gln Val Asn Phe Val Val Cys Gln 
            20                  25                  30          


Leu Phe Ala Leu Leu Ala Ala Ile Trp Phe Arg Thr Tyr Leu His Ser 
        35                  40                  45              


Ser Lys Thr Ser Ser Phe Ile Arg His Val Val Ala Thr Leu Leu Gly 
    50                  55                  60                  


Leu Tyr Leu Ala Leu Phe Cys Phe Gly Trp Tyr Ala Leu His Phe Leu 
65                  70                  75                  80  


Val Gln Ser Gly Ile Ser Tyr Cys Ile Met Ile Ile Ile Gly Val Glu 
                85                  90                  95      


Asn Met His Asn Tyr Cys Phe Val Phe Ala Leu Gly Tyr Leu Thr Val 
            100                 105                 110         


Cys Gln Val Thr Arg Val Tyr Ile Phe Asp Tyr Gly Gln Tyr Ser Ala 
        115                 120                 125             


Asp Phe Ser Gly Pro Met Met Ile Ile Thr Gln Lys Ile Thr Ser Leu 
    130                 135                 140                 


Ala Cys Glu Ile His Asp Gly Met Phe Arg Lys Asp Glu Glu Leu Thr 
145                 150                 155                 160 


Ser Ser Gln Arg Asp Leu Ala Val Arg Arg Met Pro Ser Leu Leu Glu 
                165                 170                 175     


Tyr Leu Ser Tyr Asn Cys Asn Phe Met Gly Ile Leu Ala Gly Pro Leu 
            180                 185                 190         


Cys Ser Tyr Lys Asp Tyr Ile Thr Phe Ile Glu Gly Arg Ser Tyr His 
        195                 200                 205             


Ile Thr Gln Ser Gly Glu Asn Gly Lys Glu Glu Thr Gln Tyr Glu Arg 
    210                 215                 220                 


Thr Glu Pro Ser Pro Asn Thr Ala Val Val Gln Lys Leu Leu Val Cys 
225                 230                 235                 240 


Gly Leu Ser Leu Leu Phe His Leu Thr Ile Cys Thr Thr Leu Pro Val 
                245                 250                 255     


Glu Tyr Asn Ile Asp Glu His Phe Gln Ala Thr Ala Ser Trp Pro Thr 
            260                 265                 270         


Lys Ile Ile Tyr Leu Tyr Ile Ser Leu Leu Ala Ala Arg Pro Lys Tyr 
        275                 280                 285             


Tyr Phe Ala Trp Thr Leu Ala Asp Ala Ile Asn Asn Ala Ala Gly Phe 
    290                 295                 300                 


Gly Phe Arg Gly Tyr Asp Glu Asn Gly Ala Ala Arg Trp Asp Leu Ile 
305                 310                 315                 320 


Ser Asn Leu Arg Ile Gln Gln Ile Glu Met Ser Thr Ser Phe Lys Met 
                325                 330                 335     


Phe Leu Asp Asn Trp Asn Ile Gln Thr Ala Leu Trp Leu Lys Arg Val 
            340                 345                 350         


Cys Tyr Glu Arg Thr Ser Phe Ser Pro Thr Ile Gln Thr Phe Ile Leu 
        355                 360                 365             


Ser Ala Ile Trp His Gly Val Tyr Pro Gly Tyr Tyr Leu Thr Phe Leu 
    370                 375                 380                 


Thr Gly Val Leu Met Thr Leu Ala Ala Arg Ala Met Arg Asn Asn Phe 
385                 390                 395                 400 


Arg His Tyr Phe Ile Glu Pro Ser Gln Leu Lys Leu Phe Tyr Asp Val 
                405                 410                 415     


Ile Thr Trp Ile Val Thr Gln Val Ala Ile Ser Tyr Thr Val Val Pro 
            420                 425                 430         


Phe Val Leu Leu Ser Ile Lys Pro Ser Leu Thr Phe Tyr Ser Ser Trp 
        435                 440                 445             


Tyr Tyr Cys Leu His Ile Leu Gly Ile Leu Val Leu Leu Leu Leu Pro 
    450                 455                 460                 


Val Lys Lys Thr Gln Arg Arg Lys Asn Thr His Glu Asn Ile Gln Leu 
465                 470                 475                 480 


Ser Gln Ser Lys Lys Phe Asp Glu Gly Glu Asn Ser Leu Gly Gln Asn 
                485                 490                 495     


Ser Phe Ser Thr Thr Asn Asn Val Cys Asn Gln Asn Gln Glu Ile Ala 
            500                 505                 510         


Ser Arg His Ser Ser Leu Lys Gln 
        515                 520 


<210>  5799
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  5799

Met Arg Val Ser Gly Val Leu Arg Leu Leu Ala Leu Ile Phe Ala Ile 
1               5                   10                  15      


Val Thr Thr Trp Met Phe Ile Arg Ser Tyr Met Ser Phe Ser Met Lys 
            20                  25                  30          


Thr Ile Arg Leu Pro Arg Trp Leu Ala Ala Ser Pro Thr Lys Glu Ile 
        35                  40                  45              


Gln Val Lys Lys Tyr Lys Cys Gly Leu Ile Lys Pro Cys Pro Ala Asn 
    50                  55                  60                  


Tyr Phe Ala Phe Lys Ile Cys Ser Gly Ala Ala Asn Val Val Gly Pro 
65                  70                  75                  80  


Thr Met Cys Phe Glu Asp Arg Met Ile Met Ser Pro Val Lys Asn Asn 
                85                  90                  95      


Val Gly Arg Gly Leu Asn Ile Ala Leu Val Asn Gly Thr Thr Gly Ala 
            100                 105                 110         


Val Leu Gly Gln Lys Ala Phe Asp Met Tyr Ser Gly Asp Val Met His 
        115                 120                 125             


Leu Val Lys Phe Leu Lys Glu Ile Pro Gly Gly Ala Leu Val Leu Val 
    130                 135                 140                 


Ala Ser Tyr Asp Asp Pro Gly Thr Lys Met Asn Asp Glu Ser Arg Lys 
145                 150                 155                 160 


Leu Phe Ser Asp Leu Gly Ser Ser Tyr Ala Lys Gln Leu Gly Phe Arg 
                165                 170                 175     


Asp Ser Trp Val Phe Ile Gly Ala Lys Asp Leu Arg Gly Lys Ser Pro 
            180                 185                 190         


Phe Glu Gln Phe Leu Lys Asn Ser Pro Asp Thr Asn Lys Tyr Glu Gly 
        195                 200                 205             


Trp Pro Glu Leu Leu Glu Met Glu Gly Cys Met Pro Pro Lys Pro Phe 
    210                 215                 220                 


<210>  5800
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  5800

Met Leu Cys Pro Trp Arg Thr Ala Asn Leu Gly Leu Leu Leu Ile Leu 
1               5                   10                  15      


Thr Ile Phe Leu Val Ala Glu Ala Glu Gly Ala Ala Gln Pro Asn Asn 
            20                  25                  30          


Ser Leu Met Leu Gln Thr Ser Lys Glu Asn His Ala Leu Ala Ser Ser 
        35                  40                  45              


Ser Leu Cys Met Asp Glu Lys Gln Ile Thr Gln Asn Tyr Ser Lys Val 
    50                  55                  60                  


Leu Ala Glu Val Asn Thr Ser Trp Pro Val Lys Met Ala Thr Asn Ala 
65                  70                  75                  80  


Val Leu Cys Cys Pro Pro Ile Ala Leu Arg Asn Leu Ile Ile Ile Thr 
                85                  90                  95      


Trp Glu Ile Ile Leu Arg Gly Gln Pro Ser Cys Thr Lys Ala Tyr Lys 
            100                 105                 110         


Lys Glu Thr Asn Glu Thr Lys Glu Thr Asn Cys Thr Asp Glu Arg Ile 
        115                 120                 125             


Thr Trp Val Ser Arg Pro Asp Gln Asn Ser Asp Leu Gln Ile Arg Thr 
    130                 135                 140                 


Val Ala Ile Thr His Asp Gly Tyr Tyr Arg Cys Ile Met Val Thr Pro 
145                 150                 155                 160 


Asp Gly Asn Phe His Arg Gly Tyr His Leu Gln Val Leu Val Thr Pro 
                165                 170                 175     


Glu Val Thr Leu Phe Gln Asn Arg Asn Arg Thr Ala Val Cys Lys Ala 
            180                 185                 190         


Val Ala Gly Lys Pro Ala Ala His Ile Ser Trp Ile Pro Glu Gly Asp 
        195                 200                 205             


Cys Ala Thr Lys Gln Glu Tyr Trp Ser Asn Gly Thr Val Thr Val Lys 
    210                 215                 220                 


Ser Thr Cys His Trp Glu Val His Asn Val Ser Thr Val Thr Cys His 
225                 230                 235                 240 


Val Ser His Leu Thr Gly Asn Lys Ser Leu Tyr Ile Glu Leu Leu Pro 
                245                 250                 255     


Val Pro Gly Ala Lys Lys Ser Ala Lys Leu Tyr Ile Pro Tyr Ile Ile 
            260                 265                 270         


Leu Thr Ile Ile Ile Leu Thr Ile Val Gly Phe Ile Trp Leu Leu Lys 
        275                 280                 285             


Val Asn Gly Cys Arg Lys Tyr Lys Leu Asn Lys Thr Glu Ser Thr Pro 
    290                 295                 300                 


Val Val Glu Glu Asp Glu Met Gln Pro Tyr Ala Ser Tyr Thr Glu Lys 
305                 310                 315                 320 


Asn Asn Pro Leu Tyr Asp Thr Thr Asn Lys Val Lys Ala Ser Glu Ala 
                325                 330                 335     


Leu Gln Ser Glu Val Asp Thr Asp Leu His Thr Leu 
            340                 345             


<210>  5801
<211>  1300
<212>  PRT
<213>  Homo sapiens

<400>  5801

Met Gly Thr Gly Pro Ala Gln Thr Pro Arg Ser Thr Arg Ala Gly Pro 
1               5                   10                  15      


Glu Pro Ser Pro Ala Pro Pro Gly Pro Gly Asp Thr Gly Asp Ser Asp 
            20                  25                  30          


Val Thr Gln Glu Gly Ser Gly Pro Ala Gly Ile Arg Gly Gly Glu Thr 
        35                  40                  45              


Val Ile Arg Ala Gly Met Gly Asp Ser Pro Gly Arg Gly Ala Pro Glu 
    50                  55                  60                  


Arg Arg His Lys Ala Gln Pro Gly Arg Ala Arg Lys Tyr Glu Trp Arg 
65                  70                  75                  80  


Pro Glu Gly Pro Thr Ser Met Gly Ser Leu Gly Gln Arg Glu Asp Leu 
                85                  90                  95      


Gln Asp Glu Asp Arg Asn Ser Ala Phe Thr Trp Lys Val Gln Ala Asn 
            100                 105                 110         


Asn Arg Ala Tyr Asn Gly Gln Phe Lys Glu Lys Val Ile Leu Cys Trp 
        115                 120                 125             


Gln Arg Lys Lys Tyr Lys Thr Asn Val Ile Arg Thr Ala Lys Tyr Asn 
    130                 135                 140                 


Phe Tyr Ser Phe Leu Pro Leu Asn Leu Tyr Glu Gln Phe His Arg Val 
145                 150                 155                 160 


Ser Asn Leu Phe Phe Leu Ile Ile Ile Ile Leu Gln Ser Ile Pro Asp 
                165                 170                 175     


Ile Ser Thr Leu Pro Trp Phe Ser Leu Ser Thr Pro Met Val Cys Leu 
            180                 185                 190         


Leu Phe Ile Arg Ala Thr Arg Asp Leu Val Asp Asp Met Gly Arg His 
        195                 200                 205             


Lys Ser Asp Arg Ala Ile Asn Asn Arg Pro Cys Gln Ile Leu Met Gly 
    210                 215                 220                 


Lys Ser Phe Lys Gln Lys Lys Trp Gln Asp Leu Cys Val Gly Asp Val 
225                 230                 235                 240 


Val Cys Leu Arg Lys Asp Asn Ile Val Pro Ala Asp Met Leu Leu Leu 
                245                 250                 255     


Ala Ser Thr Glu Pro Ser Ser Leu Cys Tyr Val Glu Thr Val Asp Ile 
            260                 265                 270         


Asp Gly Glu Thr Asn Leu Lys Phe Arg Gln Ala Leu Met Val Thr His 
        275                 280                 285             


Lys Glu Leu Ala Thr Ile Lys Lys Met Ala Ser Phe Gln Gly Thr Val 
    290                 295                 300                 


Thr Cys Glu Ala Pro Asn Ser Arg Met His His Phe Val Gly Cys Leu 
305                 310                 315                 320 


Glu Trp Asn Asp Lys Lys Tyr Ser Leu Asp Ile Gly Asn Leu Leu Leu 
                325                 330                 335     


Arg Gly Cys Arg Ile Arg Asn Thr Asp Thr Cys Tyr Gly Leu Val Ile 
            340                 345                 350         


Tyr Ala Gly Phe Asp Thr Lys Ile Met Lys Asn Cys Gly Lys Ile His 
        355                 360                 365             


Leu Lys Arg Thr Lys Leu Asp Leu Leu Met Asn Lys Leu Val Val Val 
    370                 375                 380                 


Ile Phe Ile Ser Val Val Leu Val Cys Leu Val Leu Ala Phe Gly Phe 
385                 390                 395                 400 


Gly Phe Ser Val Lys Glu Phe Lys Asp His His Tyr Tyr Leu Ser Gly 
                405                 410                 415     


Val His Gly Ser Ser Val Ala Ala Glu Ser Phe Phe Val Phe Trp Ser 
            420                 425                 430         


Phe Leu Ile Leu Leu Ser Val Thr Ile Pro Met Ser Met Phe Ile Leu 
        435                 440                 445             


Ser Glu Phe Ile Tyr Leu Gly Asn Ser Val Phe Ile Asp Trp Asp Val 
    450                 455                 460                 


Gln Met Tyr Tyr Lys Pro Gln Asp Val Pro Ala Lys Ala Arg Ser Thr 
465                 470                 475                 480 


Ser Leu Asn Asp His Leu Gly Gln Val Glu Tyr Ile Phe Ser Asp Lys 
                485                 490                 495     


Thr Gly Thr Leu Thr Gln Asn Ile Leu Thr Phe Asn Lys Cys Cys Ile 
            500                 505                 510         


Ser Gly Arg Val Tyr Gly Pro Asp Ser Glu Ala Thr Thr Arg Pro Lys 
        515                 520                 525             


Glu Asn Pro Tyr Leu Trp Asn Lys Phe Ala Asp Gly Lys Leu Leu Phe 
    530                 535                 540                 


His Asn Ala Ala Leu Leu His Leu Val Arg Thr Asn Gly Asp Glu Ala 
545                 550                 555                 560 


Val Arg Glu Phe Trp Arg Leu Leu Ala Ile Cys His Thr Val Met Val 
                565                 570                 575     


Arg Glu Ser Pro Arg Glu Arg Pro Asp Gln Leu Leu Tyr Gln Ala Ala 
            580                 585                 590         


Ser Pro Asp Glu Gly Ala Leu Val Thr Ala Ala Arg Asn Phe Gly Tyr 
        595                 600                 605             


Val Phe Leu Ser Arg Thr Gln Asp Thr Val Thr Ile Met Glu Leu Gly 
    610                 615                 620                 


Glu Glu Arg Val Tyr Gln Val Leu Ala Ile Met Asp Phe Asn Ser Thr 
625                 630                 635                 640 


Arg Lys Arg Met Ser Val Leu Val Arg Lys Pro Glu Gly Ala Ile Cys 
                645                 650                 655     


Leu Tyr Thr Lys Gly Ala Asp Thr Val Ile Phe Glu Arg Leu His Arg 
            660                 665                 670         


Arg Gly Ala Met Glu Phe Ala Thr Glu Glu Ala Leu Ala Ala Phe Ala 
        675                 680                 685             


Gln Glu Thr Leu Arg Thr Leu Cys Leu Ala Tyr Arg Glu Val Ala Glu 
    690                 695                 700                 


Asp Ile Tyr Glu Asp Trp Gln Gln Arg His Gln Glu Ala Ser Leu Leu 
705                 710                 715                 720 


Leu Gln Asn Arg Ala Gln Ala Leu Gln Gln Leu Leu Gly Ala Thr Ala 
                725                 730                 735     


Ile Glu Asp Arg Leu Gln Asp Gly Val Pro Glu Thr Ile Lys Cys Leu 
            740                 745                 750         


Lys Lys Ser Asn Ile Lys Ile Trp Val Leu Thr Gly Asp Lys Gln Glu 
        755                 760                 765             


Thr Ala Val Asn Ile Gly Phe Ala Cys Glu Leu Leu Ser Glu Asn Met 
    770                 775                 780                 


Leu Ile Leu Glu Glu Lys Glu Ile Ser Arg Ile Leu Glu Thr Tyr Trp 
785                 790                 795                 800 


Glu Asn Ser Asn Asn Leu Leu Thr Arg Glu Ser Leu Ser Gln Val Lys 
                805                 810                 815     


Leu Ala Leu Val Ile Asn Gly Asp Phe Leu Asp Lys Leu Leu Val Ser 
            820                 825                 830         


Leu Arg Lys Glu Pro Arg Ala Leu Ala Gln Asn Val Asn Met Asp Glu 
        835                 840                 845             


Ala Trp Gln Glu Leu Gly Gln Ser Arg Arg Asp Phe Leu Tyr Ala Arg 
    850                 855                 860                 


Arg Leu Ser Leu Leu Cys Arg Arg Phe Gly Leu Pro Leu Ala Ala Pro 
865                 870                 875                 880 


Pro Ala Gln Asp Ser Arg Ala Arg Arg Ser Ser Glu Val Leu Gln Glu 
                885                 890                 895     


Arg Ala Phe Val Asp Leu Ala Ser Lys Cys Gln Ala Val Ile Cys Cys 
            900                 905                 910         


Arg Val Thr Pro Lys Gln Lys Ala Leu Ile Val Ala Leu Val Lys Lys 
        915                 920                 925             


Tyr His Gln Val Val Thr Leu Ala Ile Gly Asp Gly Ala Asn Asp Ile 
    930                 935                 940                 


Asn Met Ile Lys Thr Ala Asp Val Gly Val Gly Leu Ala Gly Gln Glu 
945                 950                 955                 960 


Gly Met Gln Ala Val Gln Asn Ser Asp Phe Val Leu Gly Gln Phe Cys 
                965                 970                 975     


Phe Leu Gln Arg Leu Leu Leu Val His Gly Arg Trp Ser Tyr Val Arg 
            980                 985                 990         


Ile Cys Lys Phe Leu Arg Tyr Phe  Phe Tyr Lys Ser Met  Ala Ser Met 
        995                 1000                 1005             


Met Val  Gln Val Trp Phe Ala  Cys Tyr Asn Gly Phe  Thr Gly Gln 
    1010                 1015                 1020             


Pro Leu  Tyr Glu Gly Trp Phe  Leu Ala Leu Phe Asn  Leu Leu Tyr 
    1025                 1030                 1035             


Ser Thr  Leu Pro Val Leu Tyr  Ile Gly Leu Phe Glu  Gln Asp Val 
    1040                 1045                 1050             


Ser Ala  Glu Gln Ser Leu Glu  Lys Pro Glu Leu Tyr  Val Val Gly 
    1055                 1060                 1065             


Gln Lys  Asp Glu Leu Phe Asn  Tyr Trp Val Phe Val  Gln Ala Ile 
    1070                 1075                 1080             


Ala His  Gly Val Thr Thr Ser  Leu Val Asn Phe Phe  Met Thr Leu 
    1085                 1090                 1095             


Trp Ile  Ser Arg Asp Thr Ala  Gly Pro Ala Ser Phe  Ser Asp His 
    1100                 1105                 1110             


Gln Ser  Phe Ala Val Val Val  Ala Leu Ser Cys Leu  Leu Ser Ile 
    1115                 1120                 1125             


Thr Met  Glu Val Ile Leu Ile  Ile Lys Tyr Trp Thr  Ala Leu Cys 
    1130                 1135                 1140             


Val Ala  Thr Ile Leu Leu Ser  Leu Gly Phe Tyr Ala  Ile Met Thr 
    1145                 1150                 1155             


Thr Thr  Thr Gln Ser Phe Trp  Leu Phe Arg Val Ser  Pro Thr Thr 
    1160                 1165                 1170             


Phe Pro  Phe Leu Tyr Ala Asp  Leu Ser Val Met Ser  Ser Pro Ser 
    1175                 1180                 1185             


Ile Leu  Leu Val Val Leu Leu  Ser Val Ser Ile Asn  Thr Phe Pro 
    1190                 1195                 1200             


Val Leu  Ala Leu Arg Val Ile  Phe Pro Ala Leu Lys  Glu Leu Arg 
    1205                 1210                 1215             


Ala Lys  Glu Glu Lys Val Glu  Glu Gly Pro Ser Glu  Glu Ile Phe 
    1220                 1225                 1230             


Thr Met  Glu Pro Leu Pro His  Val His Arg Glu Ser  Arg Ala Arg 
    1235                 1240                 1245             


Arg Ser  Ser Tyr Ala Phe Ser  His Arg Glu Gly Tyr  Ala Asn Leu 
    1250                 1255                 1260             


Ile Thr  Gln Gly Thr Ile Leu  Arg Arg Gly Pro Gly  Val Ser Ser 
    1265                 1270                 1275             


Asp Ile  Ala Ser Glu Ser Leu  Asp Pro Ser Asp Glu  Glu Ala Ala 
    1280                 1285                 1290             


Ser Ser  Pro Lys Glu Ser Gln  
    1295                 1300 


<210>  5802
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  5802

Met Ala Thr Pro Gly Pro Val Ile Pro Glu Val Pro Phe Glu Pro Ser 
1               5                   10                  15      


Lys Pro Pro Val Ile Glu Gly Leu Ser Pro Thr Val Tyr Arg Asn Pro 
            20                  25                  30          


Glu Ser Phe Lys Glu Lys Phe Val Arg Lys Thr Arg Glu Asn Pro Val 
        35                  40                  45              


Val Pro Ile Gly Cys Leu Ala Thr Ala Ala Ala Leu Thr Tyr Gly Leu 
    50                  55                  60                  


Tyr Ser Phe His Arg Gly Asn Ser Gln Arg Ser Gln Leu Met Met Arg 
65                  70                  75                  80  


Thr Arg Ile Ala Ala Gln Gly Phe Thr Val Ala Ala Ile Leu Leu Gly 
                85                  90                  95      


Leu Ala Val Thr Ala Met Lys Ser Arg Pro 
            100                 105     


<210>  5803
<211>  866
<212>  PRT
<213>  Homo sapiens

<400>  5803

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
            20                  25                  30          


Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
        35                  40                  45              


Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg Met Pro 
    50                  55                  60                  


Gly Val Thr Pro Lys Gln Ser Asp Thr Tyr Phe Cys Met Ser Met Arg 
65                  70                  75                  80  


Ile Pro Val Asp Glu Glu Ala Phe Val Ile Asp Phe Lys Pro Arg Ala 
                85                  90                  95      


Ser Met Asp Thr Val His His Met Leu Leu Phe Gly Cys Asn Met Pro 
            100                 105                 110         


Ser Ser Thr Gly Ser Tyr Trp Phe Cys Asp Glu Gly Thr Cys Thr Asp 
        115                 120                 125             


Lys Ala Asn Ile Leu Tyr Ala Trp Ala Arg Asn Ala Pro Pro Thr Arg 
    130                 135                 140                 


Leu Pro Lys Gly Val Gly Phe Arg Val Gly Gly Glu Thr Gly Ser Lys 
145                 150                 155                 160 


Tyr Phe Val Leu Gln Val His Tyr Gly Asp Ile Ser Ala Phe Arg Asp 
                165                 170                 175     


Asn Asn Lys Asp Cys Ser Gly Val Ser Leu His Leu Thr Arg Leu Pro 
            180                 185                 190         


Gln Pro Leu Ile Ala Gly Met Tyr Leu Met Met Ser Val Asp Thr Val 
        195                 200                 205             


Ile Pro Ala Gly Glu Lys Val Val Asn Ser Asp Ile Ser Cys His Tyr 
    210                 215                 220                 


Lys Asn Tyr Pro Met His Val Phe Ala Tyr Arg Val His Thr His His 
225                 230                 235                 240 


Leu Gly Lys Val Val Ser Gly Tyr Arg Val Arg Asn Gly Gln Trp Thr 
                245                 250                 255     


Leu Ile Gly Arg Gln Ser Pro Gln Leu Pro Gln Ala Phe Tyr Pro Val 
            260                 265                 270         


Gly His Pro Val Asp Val Ser Phe Gly Asp Leu Leu Ala Ala Arg Cys 
        275                 280                 285             


Val Phe Thr Gly Glu Gly Arg Thr Glu Ala Thr His Ile Gly Gly Thr 
    290                 295                 300                 


Ser Ser Asp Glu Met Cys Asn Leu Tyr Ile Met Tyr Tyr Met Glu Ala 
305                 310                 315                 320 


Lys His Ala Val Ser Phe Met Thr Cys Thr Gln Asn Val Ala Pro Asp 
                325                 330                 335     


Met Phe Arg Thr Ile Pro Pro Glu Ala Asn Ile Pro Ile Pro Val Lys 
            340                 345                 350         


Ser Asp Met Val Met Met His Glu His His Lys Glu Thr Glu Tyr Lys 
        355                 360                 365             


Asp Lys Ile Pro Leu Leu Gln Gln Pro Lys Arg Glu Glu Glu Glu Val 
    370                 375                 380                 


Leu Asp Gln Asp Phe His Met Glu Glu Ala Leu Asp Trp Pro Gly Val 
385                 390                 395                 400 


Tyr Leu Leu Pro Gly Gln Val Ser Gly Val Ala Leu Asp Pro Lys Asn 
                405                 410                 415     


Asn Leu Val Ile Phe His Arg Gly Asp His Val Trp Asp Gly Asn Ser 
            420                 425                 430         


Phe Asp Ser Lys Phe Val Tyr Gln Gln Ile Gly Leu Gly Pro Ile Glu 
        435                 440                 445             


Glu Asp Thr Ile Leu Val Ile Asp Pro Asn Asn Ala Ala Val Leu Gln 
    450                 455                 460                 


Ser Ser Gly Lys Asn Leu Phe Tyr Leu Pro His Gly Leu Ser Ile Asp 
465                 470                 475                 480 


Lys Asp Gly Asn Tyr Trp Val Thr Asp Val Ala Leu His Gln Val Phe 
                485                 490                 495     


Lys Leu Asp Pro Asn Asn Lys Glu Gly Pro Val Leu Ile Leu Gly Arg 
            500                 505                 510         


Ser Met Gln Pro Gly Ser Asp Gln Asn His Phe Cys Gln Pro Thr Asp 
        515                 520                 525             


Val Ala Val Asp Pro Gly Thr Gly Ala Ile Tyr Val Ser Asp Gly Tyr 
    530                 535                 540                 


Cys Asn Ser Arg Ile Val Gln Phe Ser Pro Ser Gly Lys Phe Ile Thr 
545                 550                 555                 560 


Gln Trp Gly Glu Glu Ser Ser Gly Ser Ser Pro Leu Pro Gly Gln Phe 
                565                 570                 575     


Thr Val Pro His Ser Leu Ala Leu Val Pro Leu Leu Gly Gln Leu Cys 
            580                 585                 590         


Val Ala Asp Arg Glu Asn Gly Arg Ile Gln Cys Phe Lys Thr Asp Thr 
        595                 600                 605             


Lys Glu Phe Val Arg Glu Ile Lys His Ser Ser Phe Gly Arg Asn Val 
    610                 615                 620                 


Phe Ala Ile Ser Tyr Ile Pro Gly Leu Leu Phe Ala Val Asn Gly Lys 
625                 630                 635                 640 


Pro His Phe Gly Asp Gln Glu Pro Val Gln Gly Phe Val Met Asn Phe 
                645                 650                 655     


Ser Asn Gly Glu Ile Ile Asp Ile Phe Lys Pro Val Arg Lys His Phe 
            660                 665                 670         


Asp Met Pro His Asp Ile Val Ala Ser Glu Asp Gly Thr Val Tyr Ile 
        675                 680                 685             


Gly Asp Ala His Thr Asn Thr Val Trp Lys Phe Thr Leu Thr Glu Lys 
    690                 695                 700                 


Leu Glu His Arg Ser Val Lys Lys Ala Gly Ile Glu Val Gln Glu Ile 
705                 710                 715                 720 


Lys Glu Ala Glu Ala Val Val Glu Thr Lys Met Glu Asn Lys Pro Thr 
                725                 730                 735     


Ser Ser Glu Leu Gln Lys Met Gln Glu Lys Gln Lys Leu Ile Lys Glu 
            740                 745                 750         


Pro Gly Ser Gly Val Pro Val Val Leu Ile Thr Thr Leu Leu Val Ile 
        755                 760                 765             


Pro Val Val Val Leu Leu Ala Ile Ala Ile Phe Ile Arg Trp Lys Lys 
    770                 775                 780                 


Ser Arg Ala Phe Gly Asp Ser Glu His Lys Leu Glu Thr Ser Ser Gly 
785                 790                 795                 800 


Arg Val Leu Gly Arg Phe Arg Gly Lys Gly Ser Gly Gly Leu Asn Leu 
                805                 810                 815     


Gly Asn Phe Phe Ala Ser Arg Lys Gly Tyr Ser Arg Lys Gly Phe Asp 
            820                 825                 830         


Arg Leu Ser Thr Glu Gly Ser Asp Gln Glu Lys Glu Asp Asp Gly Ser 
        835                 840                 845             


Glu Ser Glu Glu Glu Tyr Ser Ala Pro Leu Pro Ala Leu Ala Pro Ser 
    850                 855                 860                 


Ser Ser 
865     


<210>  5804
<211>  887
<212>  PRT
<213>  Homo sapiens

<400>  5804

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
            20                  25                  30          


Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
        35                  40                  45              


Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg Met Pro 
    50                  55                  60                  


Gly Val Thr Pro Lys Gln Ser Asp Thr Tyr Phe Cys Met Ser Met Arg 
65                  70                  75                  80  


Ile Pro Val Asp Glu Glu Ala Phe Val Ile Asp Phe Lys Pro Arg Ala 
                85                  90                  95      


Ser Met Asp Thr Val His His Met Leu Leu Phe Gly Cys Asn Met Pro 
            100                 105                 110         


Ser Ser Thr Gly Ser Tyr Trp Phe Cys Asp Glu Gly Thr Cys Thr Asp 
        115                 120                 125             


Lys Ala Asn Ile Leu Tyr Ala Trp Ala Arg Asn Ala Pro Pro Thr Arg 
    130                 135                 140                 


Leu Pro Lys Gly Val Gly Phe Arg Val Gly Gly Glu Thr Gly Ser Lys 
145                 150                 155                 160 


Tyr Phe Val Leu Gln Val His Tyr Gly Asp Ile Ser Ala Phe Arg Asp 
                165                 170                 175     


Asn Asn Lys Asp Cys Ser Gly Val Ser Leu His Leu Thr Arg Leu Pro 
            180                 185                 190         


Gln Pro Leu Ile Ala Gly Met Tyr Leu Met Met Ser Val Asp Thr Val 
        195                 200                 205             


Ile Pro Ala Gly Glu Lys Val Val Asn Ser Asp Ile Ser Cys His Tyr 
    210                 215                 220                 


Lys Asn Tyr Pro Met His Val Phe Ala Tyr Arg Val His Thr His His 
225                 230                 235                 240 


Leu Gly Lys Val Val Ser Gly Tyr Arg Val Arg Asn Gly Gln Trp Thr 
                245                 250                 255     


Leu Ile Gly Arg Gln Ser Pro Gln Leu Pro Gln Ala Phe Tyr Pro Val 
            260                 265                 270         


Gly His Pro Val Asp Val Ser Phe Gly Asp Leu Leu Ala Ala Arg Cys 
        275                 280                 285             


Val Phe Thr Gly Glu Gly Arg Thr Glu Ala Thr His Ile Gly Gly Thr 
    290                 295                 300                 


Ser Ser Asp Glu Met Cys Asn Leu Tyr Ile Met Tyr Tyr Met Glu Ala 
305                 310                 315                 320 


Lys His Ala Val Ser Phe Met Thr Cys Thr Gln Asn Val Ala Pro Asp 
                325                 330                 335     


Met Phe Arg Thr Ile Pro Pro Glu Ala Asn Ile Pro Ile Pro Val Lys 
            340                 345                 350         


Ser Asp Met Val Met Met His Glu His His Lys Glu Thr Glu Tyr Lys 
        355                 360                 365             


Asp Lys Ile Pro Leu Leu Gln Gln Pro Lys Arg Glu Glu Glu Glu Val 
    370                 375                 380                 


Leu Asp Gln Gly Asp Phe Tyr Ser Leu Leu Ser Lys Leu Leu Gly Glu 
385                 390                 395                 400 


Arg Glu Asp Val Val His Val His Lys Tyr Asn Pro Thr Glu Lys Ala 
                405                 410                 415     


Glu Ser Glu Ser Asp Leu Val Ala Glu Ile Ala Asn Val Val Gln Lys 
            420                 425                 430         


Lys Asp Leu Gly Arg Ser Asp Ala Arg Glu Gly Ala Glu His Glu Arg 
        435                 440                 445             


Gly Asn Ala Ile Leu Val Arg Asp Arg Ile His Lys Phe His Arg Leu 
    450                 455                 460                 


Val Ser Thr Leu Arg Pro Pro Glu Ser Arg Val Phe Ser Leu Gln Gln 
465                 470                 475                 480 


Pro Pro Pro Gly Glu Gly Thr Trp Glu Pro Glu His Thr Gly Asp Phe 
                485                 490                 495     


His Met Glu Glu Ala Leu Asp Trp Pro Gly Val Tyr Leu Leu Pro Gly 
            500                 505                 510         


Gln Val Ser Gly Val Ala Leu Asp Pro Lys Asn Asn Leu Val Ile Phe 
        515                 520                 525             


His Arg Gly Asp His Val Trp Asp Gly Asn Ser Phe Asp Ser Lys Phe 
    530                 535                 540                 


Val Tyr Gln Gln Ile Gly Leu Gly Pro Ile Glu Glu Asp Thr Ile Leu 
545                 550                 555                 560 


Val Ile Asp Pro Asn Asn Ala Ala Val Leu Gln Ser Ser Gly Lys Asn 
                565                 570                 575     


Leu Phe Tyr Leu Pro His Gly Leu Ser Ile Asp Lys Asp Gly Asn Tyr 
            580                 585                 590         


Trp Val Thr Asp Val Ala Leu His Gln Val Phe Lys Leu Asp Pro Asn 
        595                 600                 605             


Asn Lys Glu Gly Pro Val Leu Ile Leu Gly Arg Ser Met Gln Pro Gly 
    610                 615                 620                 


Ser Asp Gln Asn His Phe Cys Gln Pro Thr Asp Val Ala Val Asp Pro 
625                 630                 635                 640 


Gly Thr Gly Ala Ile Tyr Val Ser Asp Gly Tyr Cys Asn Ser Arg Ile 
                645                 650                 655     


Val Gln Phe Ser Pro Ser Gly Lys Phe Ile Thr Gln Trp Gly Glu Glu 
            660                 665                 670         


Ser Ser Gly Ser Ser Pro Leu Pro Gly Gln Phe Thr Val Pro His Ser 
        675                 680                 685             


Leu Ala Leu Val Pro Leu Leu Gly Gln Leu Cys Val Ala Asp Arg Glu 
    690                 695                 700                 


Asn Gly Arg Ile Gln Cys Phe Lys Thr Asp Thr Lys Glu Phe Val Arg 
705                 710                 715                 720 


Glu Ile Lys His Ser Ser Phe Gly Arg Asn Val Phe Ala Ile Ser Tyr 
                725                 730                 735     


Ile Pro Gly Leu Leu Phe Ala Val Asn Gly Lys Pro His Phe Gly Asp 
            740                 745                 750         


Gln Glu Pro Val Gln Gly Phe Val Met Asn Phe Ser Asn Gly Glu Ile 
        755                 760                 765             


Ile Asp Ile Phe Lys Pro Val Arg Lys His Phe Asp Met Pro His Asp 
    770                 775                 780                 


Ile Val Ala Ser Glu Asp Gly Thr Val Tyr Ile Gly Asp Ala His Thr 
785                 790                 795                 800 


Asn Thr Val Trp Lys Phe Thr Leu Thr Glu Lys Leu Glu His Arg Ser 
                805                 810                 815     


Val Lys Lys Ala Gly Ile Glu Val Gln Glu Ile Lys Gly Lys Gly Ser 
            820                 825                 830         


Gly Gly Leu Asn Leu Gly Asn Phe Phe Ala Ser Arg Lys Gly Tyr Ser 
        835                 840                 845             


Arg Lys Gly Phe Asp Arg Leu Ser Thr Glu Gly Ser Asp Gln Glu Lys 
    850                 855                 860                 


Glu Asp Asp Gly Ser Glu Ser Glu Glu Glu Tyr Ser Ala Pro Leu Pro 
865                 870                 875                 880 


Ala Leu Ala Pro Ser Ser Ser 
                885         


<210>  5805
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  5805

Met Lys Ser Asp Phe Tyr Phe Gln Ala Val Tyr Thr Leu Thr Ser Leu 
1               5                   10                  15      


Tyr Arg Gln Tyr Thr Ser Leu Leu Gly Lys Met Asn Ser Glu Glu Glu 
            20                  25                  30          


Asp Glu Val Trp Gln Val Ile Ile Gly Ala Arg Ala Glu Met Thr Ser 
        35                  40                  45              


Lys His Gln Glu Tyr Leu Lys Leu Glu Thr Thr Trp Met Thr Ala Val 
    50                  55                  60                  


Gly Leu Ser Glu Met Ala Ala Glu Ala Ala Tyr Gln Thr Gly Ala Asp 
65                  70                  75                  80  


Gln Ala Ser Ile Thr Ala Arg Asn His Ile Gln Leu Val Lys Leu Gln 
                85                  90                  95      


Val Glu Glu Val His Gln Leu Ser Arg Lys Ala Glu Thr Lys Leu Ala 
            100                 105                 110         


Glu Ala Gln Ile Glu Glu Leu Arg Gln Lys Thr Gln Glu Glu Gly Glu 
        115                 120                 125             


Glu Arg Ala Glu Ser Glu Gln Glu Ala Tyr Leu Arg Glu Asp 
    130                 135                 140         


<210>  5806
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  5806

Met Leu Cys Pro Trp Arg Thr Ala Asn Leu Gly Leu Leu Leu Ile Leu 
1               5                   10                  15      


Thr Ile Phe Leu Val Ala Glu Ala Glu Gly Ala Ala Gln Pro Asn Asn 
            20                  25                  30          


Ser Leu Met Leu Gln Thr Ser Lys Glu Asn His Ala Leu Ala Ser Ser 
        35                  40                  45              


Ser Leu Cys Met Asp Glu Lys Gln Ile Thr Gln Asn Tyr Ser Lys Val 
    50                  55                  60                  


Leu Ala Glu Val Asn Thr Ser Trp Pro Val Lys Met Ala Thr Asn Ala 
65                  70                  75                  80  


Val Leu Cys Cys Pro Pro Ile Ala Leu Arg Asn Leu Ile Ile Ile Thr 
                85                  90                  95      


Trp Glu Ile Ile Leu Arg Gly Gln Pro Ser Cys Thr Lys Ala Tyr Lys 
            100                 105                 110         


Lys Glu Thr Asn Glu Thr Lys Glu Thr Asn Cys Thr Asp Glu Arg Ile 
        115                 120                 125             


Thr Trp Val Ser Arg Pro Asp Gln Asn Ser Asp Leu Gln Ile Arg Thr 
    130                 135                 140                 


Val Ala Ile Thr His Asp Gly Tyr Tyr Arg Cys Ile Met Val Thr Pro 
145                 150                 155                 160 


Asp Gly Asn Phe His Arg Gly Tyr His Leu Gln Val Leu Gly Lys Glu 
                165                 170                 175     


His His Ile Leu Arg Tyr Phe Thr Ser Pro Asp Leu 
            180                 185             


<210>  5807
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  5807

Met Leu Cys Pro Trp Arg Thr Ala Asn Leu Gly Leu Leu Leu Ile Leu 
1               5                   10                  15      


Thr Ile Phe Leu Val Ala Ala Ser Ser Ser Leu Cys Met Asp Glu Lys 
            20                  25                  30          


Gln Ile Thr Gln Asn Tyr Ser Lys Val Leu Ala Glu Val Asn Thr Ser 
        35                  40                  45              


Trp Pro Val Lys Met Ala Thr Asn Ala Val Leu Cys Cys Pro Pro Ile 
    50                  55                  60                  


Ala Leu Arg Asn Leu Ile Ile Ile Thr Trp Glu Ile Ile Leu Arg Gly 
65                  70                  75                  80  


Gln Pro Ser Cys Thr Lys Ala Tyr Lys Lys Glu Thr Asn Glu Thr Lys 
                85                  90                  95      


Glu Thr Asn Cys Thr Asp Glu Arg Ile Thr Trp Val Ser Arg Pro Asp 
            100                 105                 110         


Gln Asn Ser Asp Leu Gln Ile Arg Thr Val Ala Ile Thr His Asp Gly 
        115                 120                 125             


Tyr Tyr Arg Cys Ile Met Val Thr Pro Asp Gly Asn Phe His Arg Gly 
    130                 135                 140                 


Tyr His Leu Gln Val Leu Gly Lys Glu His His Ile Leu Arg Tyr Phe 
145                 150                 155                 160 


Thr Ser Pro Asp Leu 
                165 


<210>  5808
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  5808

Met Asp Thr Glu Ser Thr Tyr Ser Gly Tyr Ser Tyr Tyr Ser Ser His 
1               5                   10                  15      


Ser Lys Lys Ser His Arg Gln Gly Glu Arg Thr Arg Glu Arg His Lys 
            20                  25                  30          


Ser Pro Arg Asn Lys Asp Gly Arg Gly Ser Glu Lys Ser Val Thr Ile 
        35                  40                  45              


Gln Pro Pro Thr Gly Glu Pro Leu Leu Gly Asn Asp Ser Thr Arg Thr 
    50                  55                  60                  


Glu Glu Val Gln Asp Asp Asn Trp Gly Glu Thr Thr Thr Ala Ile Thr 
65                  70                  75                  80  


Gly Thr Ser Glu His Ser Ile Ser Gln Glu Asp Ile Ala Arg Ile Ser 
                85                  90                  95      


Lys Asp Met Glu Asp Ser Val Gly Leu Asp Cys Lys Arg Tyr Leu Gly 
            100                 105                 110         


Leu Thr Val Ala Ser Phe Leu Gly Leu Leu Val Phe Leu Thr Pro Ile 
        115                 120                 125             


Ala Phe Ile Leu Leu Pro Pro Ile Leu Trp Arg Asp Glu Leu Glu Pro 
    130                 135                 140                 


Cys Gly Thr Ile Cys Glu Gly Leu Phe Ile Ser Met Ala Phe Lys Leu 
145                 150                 155                 160 


Leu Ile Leu Leu Ile Gly Thr Trp Ala Leu Phe Phe Arg Lys Arg Arg 
                165                 170                 175     


Ala Asp Met Pro Arg Val Phe Val Phe Arg Ala Leu Leu Leu Val Leu 
            180                 185                 190         


Ile Phe Leu Phe Val Val Ser Tyr Trp Leu Phe Tyr Gly Val Arg Ile 
        195                 200                 205             


Leu Asp Ser Arg Asp Arg Asn Tyr Gln Gly Ile Val Gln Tyr Ala Val 
    210                 215                 220                 


Ser Leu Val Asp Ala Leu Leu Phe Ile His Tyr Leu Ala Ile Val Leu 
225                 230                 235                 240 


Leu Glu Leu Arg Gln Leu Gln Pro Met Phe Thr Leu Gln Val Val Arg 
                245                 250                 255     


Ser Thr Asp Gly Glu Ser Arg Phe Tyr Ser Leu Gly His Leu Ser Ile 
            260                 265                 270         


Gln Arg Ala Ala Leu Val Val Leu Glu Asn Tyr Tyr Lys Asp Phe Thr 
        275                 280                 285             


Ile Tyr Asn Pro Asn Leu Leu Thr Ala Ser Lys Phe Arg Ala Ala Lys 
    290                 295                 300                 


His Met Ala Gly Leu Lys Val Tyr Asn Val Asp Gly Pro Ser Asn Asn 
305                 310                 315                 320 


Ala Thr Gly Gln Ser Arg Ala Met Ile Ala Ala Ala Ala Arg Arg Arg 
                325                 330                 335     


Asp Ser Ser His Asn Glu Leu Tyr Tyr Glu Glu Ala Glu His Glu Arg 
            340                 345                 350         


Arg Val Lys Lys Arg Lys Ala Arg Leu Val Val Ala Val Glu Glu Ala 
        355                 360                 365             


Phe Ile His Ile Gln Arg Leu Gln Ala Glu Glu Gln Gln Lys Ala Pro 
    370                 375                 380                 


Gly Glu Val Met Asp Pro Arg Glu Ala Ala Gln Ala Ile Phe Pro Ser 
385                 390                 395                 400 


Met Ala Arg Ala Leu Gln Lys Tyr Leu Arg Ile Thr Arg Gln Gln Asn 
                405                 410                 415     


Tyr His Ser Met Glu Ser Ile Leu Gln His Leu Ala Phe Cys Ile Thr 
            420                 425                 430         


Asn Gly Met Thr Pro Lys Ala Phe Leu Glu Arg Tyr Leu Ser Ala Gly 
        435                 440                 445             


Pro Thr Leu Gln Tyr Asp Lys Asp Arg Trp Leu Ser Thr Gln Trp Arg 
    450                 455                 460                 


Leu Val Ser Asp Glu Ala Val Thr Asn Gly Leu Arg Asp Gly Ile Val 
465                 470                 475                 480 


Phe Val Leu Lys Cys Leu Asp Phe Ser Leu Val Val Asn Val Lys Lys 
                485                 490                 495     


Ile Pro Phe Ile Ile Leu Ser Glu Glu Phe Ile Asp Pro Lys Ser His 
            500                 505                 510         


Lys Phe Val Leu Arg Leu Gln Ser Glu Thr Ser Val 
        515                 520                 


<210>  5809
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  5809

Met Ala Glu Lys Val Asn Asn Phe Pro Pro Leu Pro Lys Phe Ile Pro 
1               5                   10                  15      


Leu Lys Pro Cys Phe Tyr Gln Asp Phe Glu Ala Asp Ile Pro Pro Gln 
            20                  25                  30          


His Val Ser Met Thr Lys Arg Leu Tyr Tyr Leu Trp Met Leu Asn Ser 
        35                  40                  45              


Val Thr Leu Ala Val Asn Leu Val Gly Cys Leu Ala Trp Leu Ile Gly 
    50                  55                  60                  


Gly Gly Gly Ala Thr Asn Phe Gly Leu Ala Phe Leu Trp Leu Ile Leu 
65                  70                  75                  80  


Phe Thr Pro Cys Ser Tyr Val Cys Trp Phe Arg Pro Ile Tyr Lys Ala 
                85                  90                  95      


Phe Lys Thr Asp Ser Ser Phe Ser Phe Met Ala Phe Phe Phe Thr Phe 
            100                 105                 110         


Met Ala Gln Leu Val Ile Ser Ile Ile Gln Ala Val Gly Ile Pro Gly 
        115                 120                 125             


Trp Gly Val Cys Gly Trp Ile Ala Thr Ile Ser Phe Phe Gly Thr Asn 
    130                 135                 140                 


Ile Gly Ser Ala Val Val Met Leu Ile Pro Thr Val Met Phe Thr Val 
145                 150                 155                 160 


Met Ala Val Phe Ser Phe Ile Ala Leu Ser Met Val His Lys Phe Tyr 
                165                 170                 175     


Arg Gly Ser Gly Gly Ser Phe Ser Lys Ala Gln Glu Glu Trp Thr Thr 
            180                 185                 190         


Gly Ala Trp Lys Asn Pro His Val Gln Gln Ala Ala Gln Asn Ala Ala 
        195                 200                 205             


Met Gly Ala Ala Gln Gly Ala Met Asn Gln Pro Gln Thr Gln Tyr Ser 
    210                 215                 220                 


Ala Thr Pro Asn Tyr Thr Tyr Ser Asn Glu Met 
225                 230                 235 


<210>  5810
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  5810

Met His Leu Arg Ile His Ala Arg Arg Ser Pro Pro Arg Arg Pro Ala 
1               5                   10                  15      


Trp Thr Leu Gly Ile Trp Phe Leu Phe Trp Gly Cys Ile Val Ser Ser 
            20                  25                  30          


Val Trp Ser Ser Ser Asn Val Ala Ser Ser Ser Ser Thr Ser Ser Ser 
        35                  40                  45              


Pro Gly Ser His Ser Gln His Glu His His Phe His Gly Ser Lys His 
    50                  55                  60                  


His Ser Val Pro Ile Ser Ile Tyr Arg Ser Pro Val Ser Leu Arg Gly 
65                  70                  75                  80  


Gly His Ala Gly Ala Thr Tyr Ile Phe Gly Lys Ser Gly Gly Leu Ile 
                85                  90                  95      


Leu Tyr Thr Trp Pro Ala Asn Asp Arg Pro Ser Thr Arg Ser Asp Arg 
            100                 105                 110         


Leu Ala Val Gly Phe Ser Thr Thr Val Lys Asp Gly Ile Leu Val Arg 
        115                 120                 125             


Ile Asp Ser Ala Pro Gly Leu Gly Asp Phe Leu Gln Leu His Ile Glu 
    130                 135                 140                 


Gln Gly Lys Ile Gly Val Val Phe Asn Ile Gly Thr Val Asp Ile Ser 
145                 150                 155                 160 


Ile Lys Glu Glu Arg Thr Pro Val Asn Asp Gly Lys Tyr His Val Val 
                165                 170                 175     


Arg Phe Thr Arg Asn Gly Gly Asn Ala Thr Leu Gln Val Asp Asn Trp 
            180                 185                 190         


Pro Val Asn Glu His Tyr Pro Thr Gly Arg Gln Leu Thr Ile Phe Asn 
        195                 200                 205             


Thr Gln Ala Gln Ile Ala Ile Gly Gly Lys Asp Lys Gly Arg Leu Phe 
    210                 215                 220                 


Gln Gly Gln Leu Ser Gly Leu Tyr Tyr Asp Gly Leu Lys Val Leu Asn 
225                 230                 235                 240 


Met Ala Ala Glu Asn Asn Pro Asn Ile Lys Ile Asn Gly Ser Val Arg 
                245                 250                 255     


Leu Val Gly Glu Val Pro Ser Ile Leu Gly Thr Thr Gln Thr Thr Ser 
            260                 265                 270         


Met Pro Pro Glu Met Ser Thr Thr Val Met Glu Thr Thr Thr Thr Met 
        275                 280                 285             


Ala Thr Thr Thr Thr Arg Lys Asn Arg Ser Thr Ala Ser Ile Gln Pro 
    290                 295                 300                 


Thr Ser Asp Asp Leu Val Ser Ser Ala Glu Cys Ser Ser Asp Asp Glu 
305                 310                 315                 320 


Asp Phe Val Glu Cys Glu Pro Ser Thr Gly Arg Ser Ala Asn Pro Thr 
                325                 330                 335     


Glu Pro Gly Ile Arg Arg Val Pro Gly Ala Ser Glu Val Ile Arg Glu 
            340                 345                 350         


Ser Ser Ser Thr Thr Gly Met Val Val Gly Ile Val Ala Ala Ala Ala 
        355                 360                 365             


Leu Cys Ile Leu Ile Leu Leu Tyr Ala Met Tyr Lys Tyr Arg Asn Arg 
    370                 375                 380                 


Asp Glu Gly Ser Tyr Gln Val Asp Glu Thr Arg Asn Tyr Ile Ser Asn 
385                 390                 395                 400 


Ser Ala Gln Ser Asn Gly Thr Leu Met Lys Glu Lys Gln Gln Ser Ser 
                405                 410                 415     


Lys Ser Gly His Lys Lys Gln Lys Asn Lys Asp Arg Glu Tyr Tyr Val 
            420                 425                 430         


<210>  5811
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  5811

Met Ala Gln Ala Leu Pro Trp Leu Leu Leu Trp Met Gly Ala Gly Val 
1               5                   10                  15      


Leu Pro Ala His Gly Thr Gln His Gly Ile Arg Leu Pro Leu Arg Ser 
            20                  25                  30          


Gly Leu Gly Gly Ala Pro Leu Gly Leu Arg Leu Pro Arg Glu Thr Asp 
        35                  40                  45              


Glu Glu Pro Glu Glu Pro Gly Arg Arg Gly Ser Phe Val Glu Met Val 
    50                  55                  60                  


Asp Asn Leu Arg Gly Lys Ser Gly Gln Gly Tyr Tyr Val Glu Met Thr 
65                  70                  75                  80  


Val Gly Ser Pro Pro Gln Thr Leu Asn Ile Leu Val Asp Thr Gly Ser 
                85                  90                  95      


Ser Asn Phe Ala Val Gly Ala Ala Pro His Pro Phe Leu His Arg Tyr 
            100                 105                 110         


Tyr Gln Arg Gln Leu Ser Ser Thr Tyr Arg Asp Leu Arg Lys Gly Val 
        115                 120                 125             


Tyr Val Pro Tyr Thr Gln Gly Lys Trp Glu Gly Glu Leu Gly Thr Asp 
    130                 135                 140                 


Leu Pro Asp Asp Ser Leu Glu Pro Phe Phe Asp Ser Leu Val Lys Gln 
145                 150                 155                 160 


Thr His Val Pro Asn Leu Phe Ser Leu Gln Leu Cys Gly Ala Gly Phe 
                165                 170                 175     


Pro Leu Asn Gln Ser Glu Val Leu Ala Ser Val Gly Gly Ser Met Ile 
            180                 185                 190         


Ile Gly Gly Ile Asp His Ser Leu Tyr Thr Gly Ser Leu Trp Tyr Thr 
        195                 200                 205             


Pro Ile Arg Arg Glu Trp Tyr Tyr Glu Val Ile Ile Val Arg Val Glu 
    210                 215                 220                 


Ile Asn Gly Gln Asp Leu Lys Met Asp Cys Lys Glu Tyr Asn Tyr Asp 
225                 230                 235                 240 


Lys Ser Ile Val Asp Ser Gly Thr Thr Asn Leu Arg Leu Pro Lys Lys 
                245                 250                 255     


Val Phe Glu Ala Ala Val Lys Ser Ile Lys Ala Ala Ser Ser Thr Glu 
            260                 265                 270         


Lys Phe Pro Asp Gly Phe Trp Leu Gly Glu Gln Leu Val Cys Trp Gln 
        275                 280                 285             


Ala Gly Thr Thr Pro Trp Asn Ile Phe Pro Val Ile Ser Leu Tyr Leu 
    290                 295                 300                 


Met Gly Glu Val Thr Asn Gln Ser Phe Arg Ile Thr Ile Leu Pro Gln 
305                 310                 315                 320 


Gln Tyr Leu Arg Pro Val Glu Asp Val Ala Thr Ser Gln Asp Asp Cys 
                325                 330                 335     


Tyr Lys Phe Ala Ile Ser Gln Ser Ser Thr Gly Thr Val Met Gly Ala 
            340                 345                 350         


Val Ile Met Glu Gly Phe Tyr Val Val Phe Asp Arg Ala Arg Lys Arg 
        355                 360                 365             


Ile Gly Phe Ala Val Ser Ala Cys His Val His Asp Glu Phe Arg Thr 
    370                 375                 380                 


Ala Ala Val Glu Gly Pro Phe Val Thr Leu Asp Met Glu Asp Cys Gly 
385                 390                 395                 400 


Tyr Asn Ile Pro Gln Thr Asp Glu Ser Thr Leu Met Thr Ile Ala Tyr 
                405                 410                 415     


Val Met Ala Ala Ile Cys Ala Leu Phe Met Leu Pro Leu Cys Leu Met 
            420                 425                 430         


Val Cys Gln Trp Arg Cys Leu Arg Cys Leu Arg Gln Gln His Asp Asp 
        435                 440                 445             


Phe Ala Asp Asp Ile Ser Leu Leu Lys 
    450                 455         


<210>  5812
<211>  476
<212>  PRT
<213>  Homo sapiens

<400>  5812

Met Ala Gln Ala Leu Pro Trp Leu Leu Leu Trp Met Gly Ala Gly Val 
1               5                   10                  15      


Leu Pro Ala His Gly Thr Gln His Gly Ile Arg Leu Pro Leu Arg Ser 
            20                  25                  30          


Gly Leu Gly Gly Ala Pro Leu Gly Leu Arg Leu Pro Arg Glu Thr Asp 
        35                  40                  45              


Glu Glu Pro Glu Glu Pro Gly Arg Arg Gly Ser Phe Val Glu Met Val 
    50                  55                  60                  


Asp Asn Leu Arg Gly Lys Ser Gly Gln Gly Tyr Tyr Val Glu Met Thr 
65                  70                  75                  80  


Val Gly Ser Pro Pro Gln Thr Leu Asn Ile Leu Val Asp Thr Gly Ser 
                85                  90                  95      


Ser Asn Phe Ala Val Gly Ala Ala Pro His Pro Phe Leu His Arg Tyr 
            100                 105                 110         


Tyr Gln Arg Gln Leu Ser Ser Thr Tyr Arg Asp Leu Arg Lys Gly Val 
        115                 120                 125             


Tyr Val Pro Tyr Thr Gln Gly Lys Trp Glu Gly Glu Leu Gly Thr Asp 
    130                 135                 140                 


Leu Val Ser Ile Pro His Gly Pro Asn Val Thr Val Arg Ala Asn Ile 
145                 150                 155                 160 


Ala Ala Ile Thr Glu Ser Asp Lys Phe Phe Ile Asn Gly Ser Asn Trp 
                165                 170                 175     


Glu Gly Ile Leu Gly Leu Ala Tyr Ala Glu Ile Ala Arg Leu Cys Gly 
            180                 185                 190         


Ala Gly Phe Pro Leu Asn Gln Ser Glu Val Leu Ala Ser Val Gly Gly 
        195                 200                 205             


Ser Met Ile Ile Gly Gly Ile Asp His Ser Leu Tyr Thr Gly Ser Leu 
    210                 215                 220                 


Trp Tyr Thr Pro Ile Arg Arg Glu Trp Tyr Tyr Glu Val Ile Ile Val 
225                 230                 235                 240 


Arg Val Glu Ile Asn Gly Gln Asp Leu Lys Met Asp Cys Lys Glu Tyr 
                245                 250                 255     


Asn Tyr Asp Lys Ser Ile Val Asp Ser Gly Thr Thr Asn Leu Arg Leu 
            260                 265                 270         


Pro Lys Lys Val Phe Glu Ala Ala Val Lys Ser Ile Lys Ala Ala Ser 
        275                 280                 285             


Ser Thr Glu Lys Phe Pro Asp Gly Phe Trp Leu Gly Glu Gln Leu Val 
    290                 295                 300                 


Cys Trp Gln Ala Gly Thr Thr Pro Trp Asn Ile Phe Pro Val Ile Ser 
305                 310                 315                 320 


Leu Tyr Leu Met Gly Glu Val Thr Asn Gln Ser Phe Arg Ile Thr Ile 
                325                 330                 335     


Leu Pro Gln Gln Tyr Leu Arg Pro Val Glu Asp Val Ala Thr Ser Gln 
            340                 345                 350         


Asp Asp Cys Tyr Lys Phe Ala Ile Ser Gln Ser Ser Thr Gly Thr Val 
        355                 360                 365             


Met Gly Ala Val Ile Met Glu Gly Phe Tyr Val Val Phe Asp Arg Ala 
    370                 375                 380                 


Arg Lys Arg Ile Gly Phe Ala Val Ser Ala Cys His Val His Asp Glu 
385                 390                 395                 400 


Phe Arg Thr Ala Ala Val Glu Gly Pro Phe Val Thr Leu Asp Met Glu 
                405                 410                 415     


Asp Cys Gly Tyr Asn Ile Pro Gln Thr Asp Glu Ser Thr Leu Met Thr 
            420                 425                 430         


Ile Ala Tyr Val Met Ala Ala Ile Cys Ala Leu Phe Met Leu Pro Leu 
        435                 440                 445             


Cys Leu Met Val Cys Gln Trp Arg Cys Leu Arg Cys Leu Arg Gln Gln 
    450                 455                 460                 


His Asp Asp Phe Ala Asp Asp Ile Ser Leu Leu Lys 
465                 470                 475     


<210>  5813
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  5813

Met Ala Gln Ala Leu Pro Trp Leu Leu Leu Trp Met Gly Ala Gly Val 
1               5                   10                  15      


Leu Pro Ala His Gly Thr Gln His Gly Ile Arg Leu Pro Leu Arg Ser 
            20                  25                  30          


Gly Leu Gly Gly Ala Pro Leu Gly Leu Arg Leu Pro Arg Glu Thr Asp 
        35                  40                  45              


Glu Glu Pro Glu Glu Pro Gly Arg Arg Gly Ser Phe Val Glu Met Val 
    50                  55                  60                  


Asp Asn Leu Arg Gly Lys Ser Gly Gln Gly Tyr Tyr Val Glu Met Thr 
65                  70                  75                  80  


Val Gly Ser Pro Pro Gln Thr Leu Asn Ile Leu Val Asp Thr Gly Ser 
                85                  90                  95      


Ser Asn Phe Ala Val Gly Ala Ala Pro His Pro Phe Leu His Arg Tyr 
            100                 105                 110         


Tyr Gln Arg Gln Leu Ser Ser Thr Tyr Arg Asp Leu Arg Lys Gly Val 
        115                 120                 125             


Tyr Val Pro Tyr Thr Gln Gly Lys Trp Glu Gly Glu Leu Gly Thr Asp 
    130                 135                 140                 


Leu Leu Cys Gly Ala Gly Phe Pro Leu Asn Gln Ser Glu Val Leu Ala 
145                 150                 155                 160 


Ser Val Gly Gly Ser Met Ile Ile Gly Gly Ile Asp His Ser Leu Tyr 
                165                 170                 175     


Thr Gly Ser Leu Trp Tyr Thr Pro Ile Arg Arg Glu Trp Tyr Tyr Glu 
            180                 185                 190         


Val Ile Ile Val Arg Val Glu Ile Asn Gly Gln Asp Leu Lys Met Asp 
        195                 200                 205             


Cys Lys Glu Tyr Asn Tyr Asp Lys Ser Ile Val Asp Ser Gly Thr Thr 
    210                 215                 220                 


Asn Leu Arg Leu Pro Lys Lys Val Phe Glu Ala Ala Val Lys Ser Ile 
225                 230                 235                 240 


Lys Ala Ala Ser Ser Thr Glu Lys Phe Pro Asp Gly Phe Trp Leu Gly 
                245                 250                 255     


Glu Gln Leu Val Cys Trp Gln Ala Gly Thr Thr Pro Trp Asn Ile Phe 
            260                 265                 270         


Pro Val Ile Ser Leu Tyr Leu Met Gly Glu Val Thr Asn Gln Ser Phe 
        275                 280                 285             


Arg Ile Thr Ile Leu Pro Gln Gln Tyr Leu Arg Pro Val Glu Asp Val 
    290                 295                 300                 


Ala Thr Ser Gln Asp Asp Cys Tyr Lys Phe Ala Ile Ser Gln Ser Ser 
305                 310                 315                 320 


Thr Gly Thr Val Met Gly Ala Val Ile Met Glu Gly Phe Tyr Val Val 
                325                 330                 335     


Phe Asp Arg Ala Arg Lys Arg Ile Gly Phe Ala Val Ser Ala Cys His 
            340                 345                 350         


Val His Asp Glu Phe Arg Thr Ala Ala Val Glu Gly Pro Phe Val Thr 
        355                 360                 365             


Leu Asp Met Glu Asp Cys Gly Tyr Asn Ile Pro Gln Thr Asp Glu Ser 
    370                 375                 380                 


Thr Leu Met Thr Ile Ala Tyr Val Met Ala Ala Ile Cys Ala Leu Phe 
385                 390                 395                 400 


Met Leu Pro Leu Cys Leu Met Val Cys Gln Trp Arg Cys Leu Arg Cys 
                405                 410                 415     


Leu Arg Gln Gln His Asp Asp Phe Ala Asp Asp Ile Ser Leu Leu Lys 
            420                 425                 430         


<210>  5814
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  5814

Met Gly Ala Leu Ala Arg Ala Leu Leu Leu Pro Leu Leu Ala Gln Trp 
1               5                   10                  15      


Leu Leu Arg Ala Ala Pro Glu Leu Ala Pro Ala Pro Phe Thr Leu Pro 
            20                  25                  30          


Leu Arg Val Ala Ala Ala Thr Asn Arg Val Val Ala Pro Thr Pro Gly 
        35                  40                  45              


Pro Gly Thr Pro Ala Glu Arg His Ala Asp Gly Leu Ala Leu Ala Leu 
    50                  55                  60                  


Glu Pro Ala Leu Ala Ser Pro Ala Gly Ala Ala Asn Phe Leu Ala Met 
65                  70                  75                  80  


Val Asp Asn Leu Gln Gly Asp Ser Gly Arg Gly Tyr Tyr Leu Glu Met 
                85                  90                  95      


Leu Ile Gly Thr Pro Pro Gln Lys Leu Gln Ile Leu Val Asp Thr Gly 
            100                 105                 110         


Ser Ser Asn Phe Ala Val Ala Gly Thr Pro His Ser Tyr Ile Asp Thr 
        115                 120                 125             


Tyr Phe Asp Thr Glu Arg Ser Ser Thr Tyr Arg Ser Lys Gly Phe Asp 
    130                 135                 140                 


Val Thr Val Lys Tyr Thr Gln Gly Ser Trp Thr Gly Phe Val Gly Glu 
145                 150                 155                 160 


Asp Leu Val Thr Ile Pro Lys Gly Phe Asn Thr Ser Phe Leu Val Asn 
                165                 170                 175     


Ile Ala Thr Ile Phe Glu Ser Glu Asn Phe Phe Leu Pro Gly Ile Lys 
            180                 185                 190         


Trp Asn Gly Ile Leu Gly Leu Ala Tyr Ala Thr Leu Ala Lys Pro Ser 
        195                 200                 205             


Ser Ser Leu Glu Thr Phe Phe Asp Ser Leu Val Thr Gln Ala Asn Ile 
    210                 215                 220                 


Pro Asn Val Phe Ser Met Gln Met Cys Gly Ala Gly Leu Pro Val Ala 
225                 230                 235                 240 


Gly Ser Gly Thr Asn Gly Gly Ser Leu Val Leu Gly Gly Ile Glu Pro 
                245                 250                 255     


Ser Leu Tyr Lys Gly Asp Ile Trp Tyr Thr Pro Ile Lys Glu Glu Trp 
            260                 265                 270         


Tyr Tyr Gln Ile Glu Ile Leu Lys Leu Glu Ile Gly Gly Gln Ser Leu 
        275                 280                 285             


Asn Leu Asp Cys Arg Glu Tyr Asn Ala Asp Lys Ala Ile Val Asp Ser 
    290                 295                 300                 


Gly Thr Thr Leu Leu Arg Leu Pro Gln Lys Val Phe Asp Ala Val Val 
305                 310                 315                 320 


Glu Ala Val Ala Arg Ala Ser Leu Leu Tyr Ile Gln Pro Met Met Gly 
                325                 330                 335     


Ala Gly Leu Asn Tyr Glu Cys Tyr Arg Phe Gly Ile Ser Pro Ser Thr 
            340                 345                 350         


Asn Ala Leu Val Ile Gly Ala Thr Val Met Glu Gly Phe Tyr Val Ile 
        355                 360                 365             


Phe Asp Arg Ala Gln Lys Arg Val Gly Phe Ala Ala Ser Pro Cys Ala 
    370                 375                 380                 


Glu Ile Ala Gly Ala Ala Val Ser Glu Ile Ser Gly Pro Phe Ser Thr 
385                 390                 395                 400 


Glu Asp Val Ala Ser Asn Cys Val Pro Ala Gln Ser Leu Ser Glu Pro 
                405                 410                 415     


Ile Leu Trp Ile Val Ser Tyr Ala Leu Met Ser Val Cys Gly Ala Ile 
            420                 425                 430         


Leu Leu Val Leu Ile Val Leu Leu Leu Leu Pro Phe Arg Cys Gln Arg 
        435                 440                 445             


Arg Pro Arg Asp Pro Glu Val Val Asn Asp Glu Ser Ser Leu Val Arg 
    450                 455                 460                 


His Arg Trp Lys 
465             


<210>  5815
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  5815

Met Gly Ala Leu Ala Arg Ala Leu Leu Leu Pro Leu Leu Ala Gln Trp 
1               5                   10                  15      


Leu Leu Arg Ala Ala Pro Glu Leu Ala Pro Ala Pro Phe Thr Leu Pro 
            20                  25                  30          


Leu Arg Val Ala Ala Ala Thr Asn Arg Val Val Ala Pro Thr Pro Gly 
        35                  40                  45              


Pro Gly Thr Pro Ala Glu Arg His Ala Asp Gly Leu Ala Leu Ala Leu 
    50                  55                  60                  


Glu Pro Ala Leu Ala Ser Pro Ala Gly Ala Ala Asn Phe Leu Ala Met 
65                  70                  75                  80  


Val Asp Asn Leu Gln Gly Asp Ser Gly Arg Gly Tyr Tyr Leu Glu Met 
                85                  90                  95      


Leu Ile Gly Thr Pro Pro Gln Lys Leu Gln Ile Leu Val Asp Thr Gly 
            100                 105                 110         


Ser Ser Asn Phe Ala Val Ala Gly Thr Pro His Ser Tyr Ile Asp Thr 
        115                 120                 125             


Tyr Phe Asp Thr Glu Arg Ser Ser Thr Tyr Arg Ser Lys Gly Phe Asp 
    130                 135                 140                 


Val Thr Val Lys Tyr Thr Gln Gly Ser Trp Thr Gly Phe Val Gly Glu 
145                 150                 155                 160 


Asp Leu Val Thr Ile Pro Lys Gly Phe Asn Thr Ser Phe Leu Val Asn 
                165                 170                 175     


Ile Ala Thr Ile Phe Glu Ser Glu Asn Phe Phe Leu Pro Gly Ile Lys 
            180                 185                 190         


Trp Asn Gly Ile Leu Gly Leu Ala Tyr Ala Thr Leu Ala Lys Pro Ser 
        195                 200                 205             


Ser Ser Leu Glu Thr Phe Phe Asp Ser Leu Val Thr Gln Ala Asn Ile 
    210                 215                 220                 


Pro Asn Val Phe Ser Met Gln Met Cys Gly Ala Gly Leu Pro Val Ala 
225                 230                 235                 240 


Gly Ser Gly Thr Asn Gly Gly Ser Leu Val Leu Gly Gly Ile Glu Pro 
                245                 250                 255     


Ser Leu Tyr Lys Gly Asp Ile Trp Tyr Thr Pro Ile Lys Glu Glu Trp 
            260                 265                 270         


Tyr Tyr Gln Ile Glu Ile Leu Lys Leu Glu Ile Gly Gly Gln Ser Leu 
        275                 280                 285             


Asn Leu Asp Cys Arg Glu Tyr Asn Ala Asp Lys Ala Ile Val Asp Ser 
    290                 295                 300                 


Gly Thr Thr Leu Leu Arg Leu Pro Gln Lys Val Phe Asp Ala Val Val 
305                 310                 315                 320 


Glu Ala Val Ala Arg Ala Ser Leu Ile Pro Glu Phe Ser Asp Gly Phe 
                325                 330                 335     


Trp Thr Gly Ser Gln Leu Ala Cys Trp Thr Asn Ser Glu Thr Pro Trp 
            340                 345                 350         


Ser Tyr Phe Pro Lys Ile Ser Ile Tyr Leu Arg Asp Glu Asn Ser Ser 
        355                 360                 365             


Arg Ser Phe Arg Ile Thr Ile Leu Pro Gln Lys Leu Gln Val Leu Gln 
    370                 375                 380                 


Cys Leu Lys Phe Pro Gly Leu Ser Gln Gln Arg Met 
385                 390                 395     


<210>  5816
<211>  1235
<212>  PRT
<213>  Homo sapiens

<400>  5816

Met Trp Asn Tyr Asp Cys Asp Asp Pro Leu Val Ser Ala Leu Pro Gln 
1               5                   10                  15      


Ala Ser Phe Ser Ser Ser Ser Glu Leu Ser Ser Ser His Gly Pro Gly 
            20                  25                  30          


Phe Ala Arg Leu Asn Arg Arg Asp Gly Ala Gly Gly Trp Ser Pro Leu 
        35                  40                  45              


Val Ser Asn Lys Tyr Gln Trp Leu Gln Ile Asp Leu Gly Glu Arg Met 
    50                  55                  60                  


Glu Val Thr Ala Val Ala Thr Gln Gly Gly Tyr Gly Ser Ser Asn Trp 
65                  70                  75                  80  


Val Thr Ser Tyr Leu Leu Met Phe Ser Asp Ser Gly Trp Asn Trp Lys 
                85                  90                  95      


Gln Tyr Arg Gln Glu Asp Ser Ile Trp Gly Phe Ser Gly Asn Ala Asn 
            100                 105                 110         


Ala Asp Ser Val Val Tyr Tyr Arg Leu Gln Pro Ser Ile Lys Ala Arg 
        115                 120                 125             


Phe Leu Arg Phe Ile Pro Leu Glu Trp Asn Pro Lys Gly Arg Ile Gly 
    130                 135                 140                 


Met Arg Ile Glu Val Phe Gly Cys Ala Tyr Arg Ser Glu Val Val Asp 
145                 150                 155                 160 


Leu Asp Gly Lys Ser Ser Leu Leu Tyr Arg Phe Asp Gln Lys Ser Leu 
                165                 170                 175     


Ser Pro Ile Lys Asp Ile Ile Ser Leu Lys Phe Lys Thr Met Gln Ser 
            180                 185                 190         


Asp Gly Ile Leu Leu His Arg Glu Gly Pro Asn Gly Asp His Ile Thr 
        195                 200                 205             


Leu Gln Leu Arg Arg Ala Arg Leu Phe Leu Leu Ile Asn Ser Gly Glu 
    210                 215                 220                 


Ala Lys Leu Pro Ser Thr Ser Thr Leu Val Asn Leu Thr Leu Gly Ser 
225                 230                 235                 240 


Leu Leu Asp Asp Gln His Trp His Ser Val Leu Ile Gln Arg Leu Gly 
                245                 250                 255     


Lys Gln Val Asn Phe Thr Val Asp Glu His Arg His His Phe His Ala 
            260                 265                 270         


Arg Gly Glu Phe Asn Leu Met Asn Leu Asp Tyr Glu Gly Asn Val Ser 
        275                 280                 285             


Phe Ser Cys Ser Gln Pro Gln Ser Met Pro Val Thr Phe Leu Ser Ser 
    290                 295                 300                 


Arg Ser Tyr Leu Ala Leu Pro Asp Phe Ser Gly Glu Glu Glu Val Ser 
305                 310                 315                 320 


Ala Thr Phe Gln Phe Arg Thr Trp Asn Lys Ala Gly Leu Leu Leu Phe 
                325                 330                 335     


Ser Glu Leu Gln Leu Ile Ser Gly Gly Ile Leu Leu Phe Leu Ser Asp 
            340                 345                 350         


Gly Lys Leu Lys Ser Asn Leu Tyr Gln Pro Gly Lys Leu Pro Ser Asp 
        355                 360                 365             


Ile Thr Ala Gly Val Glu Leu Asn Asp Gly Gln Trp His Ser Val Ser 
    370                 375                 380                 


Leu Ser Ala Lys Lys Asn His Leu Ser Val Ala Val Asp Gly Gln Met 
385                 390                 395                 400 


Ala Ser Ala Ala Pro Leu Leu Gly Pro Glu Gln Ile Tyr Ser Gly Gly 
                405                 410                 415     


Thr Tyr Tyr Phe Gly Gly Cys Pro Asp Lys Ser Phe Gly Ser Lys Cys 
            420                 425                 430         


Lys Ser Pro Leu Gly Gly Phe Gln Gly Cys Met Arg Leu Ile Ser Ile 
        435                 440                 445             


Ser Gly Lys Val Val Asp Leu Ile Ser Val Gln Gln Gly Ser Leu Gly 
    450                 455                 460                 


Asn Phe Ser Asp Leu Gln Ile Asp Ser Cys Gly Ile Ser Asp Arg Cys 
465                 470                 475                 480 


Leu Pro Asn Tyr Cys Glu His Gly Gly Glu Cys Ser Gln Ser Trp Ser 
                485                 490                 495     


Thr Phe His Cys Asn Cys Thr Asn Thr Gly Tyr Arg Gly Ala Thr Cys 
            500                 505                 510         


His Asn Ser Ile Tyr Glu Gln Ser Cys Glu Ala Tyr Lys His Arg Gly 
        515                 520                 525             


Asn Thr Ser Gly Phe Tyr Tyr Ile Asp Ser Asp Gly Ser Gly Pro Leu 
    530                 535                 540                 


Glu Pro Phe Leu Leu Tyr Cys Asn Met Thr Glu Thr Ala Trp Thr Ile 
545                 550                 555                 560 


Ile Gln His Asn Gly Ser Asp Leu Thr Arg Val Arg Asn Thr Asn Pro 
                565                 570                 575     


Glu Asn Pro Tyr Ala Gly Phe Phe Glu Tyr Val Ala Ser Met Glu Gln 
            580                 585                 590         


Leu Gln Ala Thr Ile Asn Arg Ala Glu His Cys Glu Gln Glu Phe Thr 
        595                 600                 605             


Tyr Tyr Cys Lys Lys Ser Arg Leu Val Asn Lys Gln Asp Gly Thr Pro 
    610                 615                 620                 


Leu Ser Trp Trp Val Gly Arg Thr Asn Glu Thr Gln Thr Tyr Trp Gly 
625                 630                 635                 640 


Gly Ser Ser Pro Asp Leu Gln Lys Cys Thr Cys Gly Leu Glu Gly Asn 
                645                 650                 655     


Cys Ile Asp Ser Gln Tyr Tyr Cys Asn Cys Asp Ala Asp Arg Asn Glu 
            660                 665                 670         


Trp Thr Asn Asp Thr Gly Leu Leu Ala Tyr Lys Glu His Leu Pro Val 
        675                 680                 685             


Thr Lys Ile Val Ile Thr Asp Thr Gly Arg Leu His Ser Glu Ala Ala 
    690                 695                 700                 


Tyr Lys Leu Gly Pro Leu Leu Cys Gln Gly Asp Arg Ser Phe Trp Asn 
705                 710                 715                 720 


Ser Ala Ser Phe Asp Thr Glu Ala Ser Tyr Leu His Phe Pro Thr Phe 
                725                 730                 735     


His Gly Glu Leu Ser Ala Asp Val Ser Phe Phe Phe Lys Thr Thr Ala 
            740                 745                 750         


Ser Ser Gly Val Phe Leu Glu Asn Leu Gly Ile Ala Asp Phe Ile Arg 
        755                 760                 765             


Ile Glu Leu Arg Ser Pro Thr Val Val Thr Phe Ser Phe Asp Val Gly 
    770                 775                 780                 


Asn Gly Pro Phe Glu Ile Ser Val Gln Ser Pro Thr His Phe Asn Asp 
785                 790                 795                 800 


Asn Gln Trp His His Val Arg Val Glu Arg Asn Met Lys Glu Ala Ser 
                805                 810                 815     


Leu Gln Val Asp Gln Leu Thr Pro Lys Thr Gln Pro Ala Pro Ala Asp 
            820                 825                 830         


Gly His Val Leu Leu Gln Leu Asn Ser Gln Leu Phe Val Gly Gly Thr 
        835                 840                 845             


Ala Thr Arg Gln Arg Gly Phe Leu Gly Cys Ile Arg Ser Leu Gln Leu 
    850                 855                 860                 


Asn Gly Met Thr Leu Asp Leu Glu Glu Arg Ala Gln Val Thr Pro Glu 
865                 870                 875                 880 


Val Gln Pro Gly Cys Arg Gly His Cys Ser Ser Tyr Gly Lys Leu Cys 
                885                 890                 895     


Arg Asn Gly Gly Lys Cys Arg Glu Arg Pro Ile Gly Phe Phe Cys Asp 
            900                 905                 910         


Cys Thr Phe Ser Ala Tyr Thr Gly Pro Phe Cys Ser Asn Glu Ile Ser 
        915                 920                 925             


Ala Tyr Phe Gly Ser Gly Ser Ser Val Ile Tyr Asn Phe Gln Glu Asn 
    930                 935                 940                 


Tyr Leu Leu Ser Lys Asn Ser Ser Ser His Ala Ala Ser Phe His Gly 
945                 950                 955                 960 


Asp Met Lys Leu Ser Arg Glu Met Ile Lys Phe Ser Phe Arg Thr Thr 
                965                 970                 975     


Arg Thr Pro Ser Leu Leu Leu Phe Val Ser Ser Phe Tyr Lys Glu Tyr 
            980                 985                 990         


Leu Ser Val Ile Ile Ala Lys Asn  Gly Ser Leu Gln Ile  Arg Tyr Lys 
        995                 1000                 1005             


Leu Asn  Lys Tyr Gln Glu Pro  Asp Val Val Asn Phe  Asp Phe Lys 
    1010                 1015                 1020             


Asn Met  Ala Asp Gly Gln Leu  His His Ile Met Ile  Asn Arg Glu 
    1025                 1030                 1035             


Glu Gly  Val Val Phe Ile Glu  Ile Asp Asp Asn Arg  Arg Arg Gln 
    1040                 1045                 1050             


Val His  Leu Ser Ser Gly Thr  Glu Phe Ser Ala Val  Lys Ser Leu 
    1055                 1060                 1065             


Val Leu  Gly Arg Ile Leu Glu  His Ser Asp Val Asp  Gln Asp Thr 
    1070                 1075                 1080             


Ala Leu  Ala Gly Ala Gln Gly  Phe Thr Gly Cys Leu  Ser Ala Val 
    1085                 1090                 1095             


Gln Leu  Ser His Val Ala Pro  Leu Lys Ala Ala Leu  His Pro Ser 
    1100                 1105                 1110             


His Pro  Asp Pro Val Thr Val  Thr Gly His Val Thr  Glu Ser Ser 
    1115                 1120                 1125             


Cys Met  Ala Gln Pro Gly Thr  Asp Ala Thr Ser Arg  Glu Arg Thr 
    1130                 1135                 1140             


His Ser  Phe Ala Asp His Ser  Gly Thr Ile Asp Asp  Arg Glu Pro 
    1145                 1150                 1155             


Leu Ala  Asn Ala Ile Lys Ser  Asp Ser Ala Val Ile  Gly Gly Leu 
    1160                 1165                 1170             


Ile Ala  Val Val Ile Phe Ile  Leu Leu Cys Ile Thr  Ala Ile Ala 
    1175                 1180                 1185             


Val Arg  Ile Tyr Gln Gln Lys  Arg Leu Tyr Lys Arg  Ser Glu Ala 
    1190                 1195                 1200             


Lys Arg  Ser Glu Asn Val Asp  Ser Ala Glu Ala Val  Leu Lys Ser 
    1205                 1210                 1215             


Glu Leu  Asn Ile Gln Asn Ala  Val Asn Glu Asn Gln  Lys Glu Tyr 
    1220                 1225                 1230             


Phe Phe  
    1235 


<210>  5817
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  5817

Met Gly Pro Arg Ala Arg Pro Ala Leu Leu Leu Leu Met Leu Leu Gln 
1               5                   10                  15      


Thr Ala Val Leu Gln Gly Arg Leu Leu Arg Ser His Ser Leu His Tyr 
            20                  25                  30          


Leu Phe Met Gly Ala Ser Glu Gln Asp Leu Gly Leu Ser Leu Phe Glu 
        35                  40                  45              


Ala Leu Gly Tyr Val Asp Asp Gln Leu Phe Val Phe Tyr Asp His Glu 
    50                  55                  60                  


Ser Arg Arg Val Glu Pro Arg Thr Pro Trp Val Ser Ser Arg Ile Ser 
65                  70                  75                  80  


Ser Gln Met Trp Leu Gln Leu Ser Gln Ser Leu Lys Gly Trp Asp His 
                85                  90                  95      


Met Phe Thr Val Asp Phe Trp Thr Ile Met Glu Asn His Asn His Ser 
            100                 105                 110         


Lys Val Thr Thr Leu Arg Cys Arg Ala Leu Asn Tyr Tyr Pro Gln Asn 
        115                 120                 125             


Ile Thr Met Lys Trp Leu Lys Asp Lys Gln Pro Met Asp Ala Lys Glu 
    130                 135                 140                 


Phe Glu Pro Lys Asp Val Leu Pro Asn Gly Asp Gly Thr Tyr Gln Gly 
145                 150                 155                 160 


Trp Ile Thr Leu Ala Val Pro Pro Gly Glu Glu Gln Arg Tyr Thr Cys 
                165                 170                 175     


Gln Val Glu His Pro Gly Leu Asp Gln Pro Leu Ile Val Ile Trp Glu 
            180                 185                 190         


Pro Ser Pro Ser Gly Thr Leu Val Ile Gly Val Ile Ser Gly Ile Ala 
        195                 200                 205             


Val Phe Val Val Ile Leu Phe Ile Gly Ile Leu Phe Ile Ile Leu Arg 
    210                 215                 220                 


Lys Arg Gln Gly Ser Arg Gly Ala Met Gly His Tyr Val Leu Ala Glu 
225                 230                 235                 240 


Arg Glu 
        


<210>  5818
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  5818

Met Gly Pro Arg Ala Arg Pro Ala Leu Leu Leu Leu Met Leu Leu Gln 
1               5                   10                  15      


Thr Ala Val Leu Gln Gly Arg Leu Leu Arg Ser His Ser Leu His Tyr 
            20                  25                  30          


Leu Phe Met Gly Ala Ser Glu Gln Asp Leu Gly Leu Ser Leu Phe Glu 
        35                  40                  45              


Ala Leu Gly Tyr Val Asp Asp Gln Leu Phe Val Phe Tyr Asp His Glu 
    50                  55                  60                  


Ser Arg Arg Val Glu Pro Arg Thr Pro Trp Val Ser Ser Arg Ile Ser 
65                  70                  75                  80  


Ser Gln Met Trp Leu Gln Leu Ser Gln Ser Leu Lys Gly Trp Asp His 
                85                  90                  95      


Met Phe Thr Val Asp Phe Trp Thr Ile Met Glu Asn His Asn His Ser 
            100                 105                 110         


Lys Val Pro Pro Leu Val Lys Val Thr His His Val Thr Ser Ser Val 
        115                 120                 125             


Thr Thr Leu Arg Cys Arg Ala Leu Asn Tyr Tyr Pro Gln Asn Ile Thr 
    130                 135                 140                 


Met Lys Trp Leu Lys Asp Lys Gln Pro Met Asp Ala Lys Glu Phe Glu 
145                 150                 155                 160 


Pro Lys Asp Val Leu Pro Asn Gly Asp Gly Thr Tyr Gln Gly Trp Ile 
                165                 170                 175     


Thr Leu Ala Val Pro Pro Gly Glu Glu Gln Arg Tyr Thr Cys Gln Val 
            180                 185                 190         


Glu His Pro Gly Leu Asp Gln Pro Leu Ile Val Ile Trp Glu Pro Ser 
        195                 200                 205             


Pro Ser Gly Thr Leu Val Ile Gly Val Ile Ser Gly Ile Ala Val Phe 
    210                 215                 220                 


Val Val Ile Leu Phe Ile Gly Ile Leu Phe Ile Ile Leu Arg Lys Arg 
225                 230                 235                 240 


Gln Gly Ser Arg Gly Ala Met Gly His Tyr Val Leu Ala Glu Arg Glu 
                245                 250                 255     


<210>  5819
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  5819

Met Gly Pro Arg Ala Arg Pro Ala Leu Leu Leu Leu Met Leu Leu Gln 
1               5                   10                  15      


Thr Ala Val Leu Gln Gly Arg Leu Leu Arg Ser His Ser Leu His Tyr 
            20                  25                  30          


Leu Phe Met Gly Ala Ser Glu Gln Asp Leu Gly Leu Ser Leu Phe Glu 
        35                  40                  45              


Ala Leu Gly Tyr Val Asp Asp Gln Leu Phe Val Phe Tyr Asp His Glu 
    50                  55                  60                  


Ser Arg Arg Val Glu Pro Arg Thr Pro Trp Val Ser Ser Arg Ile Ser 
65                  70                  75                  80  


Ser Gln Met Trp Leu Gln Leu Ser Gln Ser Leu Lys Gly Trp Asp His 
                85                  90                  95      


Met Phe Thr Val Asp Phe Trp Thr Ile Met Glu Asn His Asn His Ser 
            100                 105                 110         


Lys Glu Ser His Thr Leu Gln Val Ile Leu Gly Cys Glu Met Gln Glu 
        115                 120                 125             


Asp Asn Ser Thr Glu Gly Tyr Trp Lys Tyr Gly Tyr Asp Gly Gln Asp 
    130                 135                 140                 


His Leu Glu Phe Cys Pro Asp Thr Leu Asp Trp Arg Ala Ala Glu Pro 
145                 150                 155                 160 


Arg Ala Trp Pro Thr Lys Leu Glu Trp Glu Arg His Lys Ile Arg Ala 
                165                 170                 175     


Arg Gln Asn Arg Ala Tyr Leu Glu Arg Asp Cys Pro Ala Gln Leu Gln 
            180                 185                 190         


Gln Leu Leu Glu Leu Gly Arg Gly Val Leu Asp Gln Gln Val Thr Thr 
        195                 200                 205             


Leu Arg Cys Arg Ala Leu Asn Tyr Tyr Pro Gln Asn Ile Thr Met Lys 
    210                 215                 220                 


Trp Leu Lys Asp Lys Gln Pro Met Asp Ala Lys Glu Phe Glu Pro Lys 
225                 230                 235                 240 


Asp Val Leu Pro Asn Gly Asp Gly Thr Tyr Gln Gly Trp Ile Thr Leu 
                245                 250                 255     


Ala Val Pro Pro Gly Glu Glu Gln Arg Tyr Thr Cys Gln Val Glu His 
            260                 265                 270         


Pro Gly Leu Asp Gln Pro Leu Ile Val Ile Trp Glu Pro Ser Pro Ser 
        275                 280                 285             


Gly Thr Leu Val Ile Gly Val Ile Ser Gly Ile Ala Val Phe Val Val 
    290                 295                 300                 


Ile Leu Phe Ile Gly Ile Leu Phe Ile Ile Leu Arg Lys Arg Gln Gly 
305                 310                 315                 320 


Ser Arg Gly Ala Met Gly His Tyr Val Leu Ala Glu Arg Glu 
                325                 330                 


<210>  5820
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  5820

Met Gly Pro Arg Ala Arg Pro Ala Leu Leu Leu Leu Met Leu Leu Gln 
1               5                   10                  15      


Thr Ala Val Leu Gln Gly Arg Leu Leu Gln Ser His Thr Leu Gln Val 
            20                  25                  30          


Ile Leu Gly Cys Glu Met Gln Glu Asp Asn Ser Thr Glu Gly Tyr Trp 
        35                  40                  45              


Lys Tyr Gly Tyr Asp Gly Gln Asp His Leu Glu Phe Cys Pro Asp Thr 
    50                  55                  60                  


Leu Asp Trp Arg Ala Ala Glu Pro Arg Ala Trp Pro Thr Lys Leu Glu 
65                  70                  75                  80  


Trp Glu Arg His Lys Ile Arg Ala Arg Gln Asn Arg Ala Tyr Leu Glu 
                85                  90                  95      


Arg Asp Cys Pro Ala Gln Leu Gln Gln Leu Leu Glu Leu Gly Arg Gly 
            100                 105                 110         


Val Leu Asp Gln Gln Val Pro Pro Leu Val Lys Val Thr His His Val 
        115                 120                 125             


Thr Ser Ser Val Thr Thr Leu Arg Cys Arg Ala Leu Asn Tyr Tyr Pro 
    130                 135                 140                 


Gln Asn Ile Thr Met Lys Trp Leu Lys Asp Lys Gln Pro Met Asp Ala 
145                 150                 155                 160 


Lys Glu Phe Glu Pro Lys Asp Val Leu Pro Asn Gly Asp Gly Thr Tyr 
                165                 170                 175     


Gln Gly Trp Ile Thr Leu Ala Val Pro Pro Gly Glu Glu Gln Arg Tyr 
            180                 185                 190         


Thr Cys Gln Val Glu His Pro Gly Leu Asp Gln Pro Leu Ile Val Ile 
        195                 200                 205             


Trp Glu Pro Ser Pro Ser Gly Thr Leu Val Ile Gly Val Ile Ser Gly 
    210                 215                 220                 


Ile Ala Val Phe Val Val Ile Leu Phe Ile Gly Ile Leu Phe Ile Ile 
225                 230                 235                 240 


Leu Arg Lys Arg Gln Gly Ser Arg Gly Ala Met Gly His Tyr Val Leu 
                245                 250                 255     


Ala Glu Arg Glu 
            260 


<210>  5821
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  5821

Met Gly Pro Arg Ala Arg Pro Ala Leu Leu Leu Leu Met Leu Leu Gln 
1               5                   10                  15      


Thr Ala Val Leu Gln Gly Arg Leu Leu Gln Ser His Thr Leu Gln Val 
            20                  25                  30          


Ile Leu Gly Cys Glu Met Gln Glu Asp Asn Ser Thr Glu Gly Tyr Trp 
        35                  40                  45              


Lys Tyr Gly Tyr Asp Gly Gln Asp His Leu Glu Phe Cys Pro Asp Thr 
    50                  55                  60                  


Leu Asp Trp Arg Ala Ala Glu Pro Arg Ala Trp Pro Thr Lys Leu Glu 
65                  70                  75                  80  


Trp Glu Arg His Lys Ile Arg Ala Arg Gln Asn Arg Ala Tyr Leu Glu 
                85                  90                  95      


Arg Asp Cys Pro Ala Gln Leu Gln Gln Leu Leu Glu Leu Gly Arg Gly 
            100                 105                 110         


Val Leu Asp Gln Gln Val Thr Thr Leu Arg Cys Arg Ala Leu Asn Tyr 
        115                 120                 125             


Tyr Pro Gln Asn Ile Thr Met Lys Trp Leu Lys Asp Lys Gln Pro Met 
    130                 135                 140                 


Asp Ala Lys Glu Phe Glu Pro Lys Asp Val Leu Pro Asn Gly Asp Gly 
145                 150                 155                 160 


Thr Tyr Gln Gly Trp Ile Thr Leu Ala Val Pro Pro Gly Glu Glu Gln 
                165                 170                 175     


Arg Tyr Thr Cys Gln Val Glu His Pro Gly Leu Asp Gln Pro Leu Ile 
            180                 185                 190         


Val Ile Trp Glu Pro Ser Pro Ser Gly Thr Leu Val Ile Gly Val Ile 
        195                 200                 205             


Ser Gly Ile Ala Val Phe Val Val Ile Leu Phe Ile Gly Ile Leu Phe 
    210                 215                 220                 


Ile Ile Leu Arg Lys Arg Gln Gly Ser Arg Gly Ala Met Gly His Tyr 
225                 230                 235                 240 


Val Leu Ala Glu Arg Glu 
                245     


<210>  5822
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  5822

Met Gly Pro Arg Ala Arg Pro Ala Leu Leu Leu Leu Met Leu Leu Gln 
1               5                   10                  15      


Thr Ala Val Leu Gln Gly Arg Leu Leu Pro Leu Gly Tyr Val Asp Asp 
            20                  25                  30          


Gln Leu Phe Val Phe Tyr Asp His Glu Ser Arg Arg Val Glu Pro Arg 
        35                  40                  45              


Thr Pro Trp Val Ser Ser Arg Ile Ser Ser Gln Met Trp Leu Gln Leu 
    50                  55                  60                  


Ser Gln Ser Leu Lys Gly Trp Asp His Met Phe Thr Val Asp Phe Trp 
65                  70                  75                  80  


Thr Ile Met Glu Asn His Asn His Ser Lys Glu Ser His Thr Leu Gln 
                85                  90                  95      


Val Ile Leu Gly Cys Glu Met Gln Glu Asp Asn Ser Thr Glu Gly Tyr 
            100                 105                 110         


Trp Lys Tyr Gly Tyr Asp Gly Gln Asp His Leu Glu Phe Cys Pro Asp 
        115                 120                 125             


Thr Leu Asp Trp Arg Ala Ala Glu Pro Arg Ala Trp Pro Thr Lys Leu 
    130                 135                 140                 


Glu Trp Glu Arg His Lys Ile Arg Ala Arg Gln Asn Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Arg Asp Cys Pro Ala Gln Leu Gln Gln Leu Leu Glu Leu Gly Arg 
                165                 170                 175     


Gly Val Leu Asp Gln Gln Val Pro Pro Leu Val Lys Val Thr His His 
            180                 185                 190         


Val Thr Ser Ser Val Thr Thr Leu Arg Cys Arg Ala Leu Asn Tyr Tyr 
        195                 200                 205             


Pro Gln Asn Ile Thr Met Lys Trp Leu Lys Asp Lys Gln Pro Met Asp 
    210                 215                 220                 


Ala Lys Glu Phe Glu Pro Lys Asp Val Leu Pro Asn Gly Asp Gly Thr 
225                 230                 235                 240 


Tyr Gln Gly Trp Ile Thr Leu Ala Val Pro Pro Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys Gln Val Glu His Pro Gly Leu Asp Gln Pro Leu Ile Val 
            260                 265                 270         


Ile Trp Glu Pro Ser Pro Ser Gly Thr Leu Val Ile Gly Val Ile Ser 
        275                 280                 285             


Gly Ile Ala Val Phe Val Val Ile Leu Phe Ile Gly Ile Leu Phe Ile 
    290                 295                 300                 


Ile Leu Arg Lys Arg Gln Gly Ser Arg Gly Ala Met Gly His Tyr Val 
305                 310                 315                 320 


Leu Ala Glu Arg Glu 
                325 


<210>  5823
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  5823

Met Gly Pro Arg Ala Arg Pro Ala Leu Leu Leu Leu Met Leu Leu Gln 
1               5                   10                  15      


Thr Ala Val Leu Gln Gly Arg Leu Leu Leu Pro Pro Leu Val Lys Val 
            20                  25                  30          


Thr His His Val Thr Ser Ser Val Thr Thr Leu Arg Cys Arg Ala Leu 
        35                  40                  45              


Asn Tyr Tyr Pro Gln Asn Ile Thr Met Lys Trp Leu Lys Asp Lys Gln 
    50                  55                  60                  


Pro Met Asp Ala Lys Glu Phe Glu Pro Lys Asp Val Leu Pro Asn Gly 
65                  70                  75                  80  


Asp Gly Thr Tyr Gln Gly Trp Ile Thr Leu Ala Val Pro Pro Gly Glu 
                85                  90                  95      


Glu Gln Arg Tyr Thr Cys Gln Val Glu His Pro Gly Leu Asp Gln Pro 
            100                 105                 110         


Leu Ile Val Ile Trp Glu Pro Ser Pro Ser Gly Thr Leu Val Ile Gly 
        115                 120                 125             


Val Ile Ser Gly Ile Ala Val Phe Val Val Ile Leu Phe Ile Gly Ile 
    130                 135                 140                 


Leu Phe Ile Ile Leu Arg Lys Arg Gln Gly Ser Arg Gly Ala Met Gly 
145                 150                 155                 160 


His Tyr Val Leu Ala Glu Arg Glu 
                165             


<210>  5824
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  5824

Met Gly Pro Arg Ala Arg Pro Ala Leu Leu Leu Leu Met Leu Leu Gln 
1               5                   10                  15      


Thr Ala Val Leu Gln Gly Arg Leu Leu Gln Pro Ser Pro Ser Gly Thr 
            20                  25                  30          


Leu Val Ile Gly Val Ile Ser Gly Ile Ala Val Phe Val Val Ile Leu 
        35                  40                  45              


Phe Ile Gly Ile Leu Phe Ile Ile Leu Arg Lys Arg Gln Gly Ser Arg 
    50                  55                  60                  


Gly Ala Met Gly His Tyr Val Leu Ala Glu Arg Glu 
65                  70                  75      


<210>  5825
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  5825

Met Ala Glu Gln Thr Tyr Ser Trp Ala Tyr Ser Leu Val Asp Ser Ser 
1               5                   10                  15      


Gln Val Ser Thr Phe Leu Ile Ser Ile Leu Leu Ile Val Tyr Gly Ser 
            20                  25                  30          


Phe Arg Ser Leu Asn Met Asp Phe Glu Asn Gln Asp Lys Glu Lys Asp 
        35                  40                  45              


Ser Asn Ser Ser Ser Gly Ser Phe Asn Gly Asn Ser Thr Asn Asn Ser 
    50                  55                  60                  


Ile Gln Thr Ile Asp Ser Thr Gln Ala Leu Phe Leu Pro Ile Gly Ala 
65                  70                  75                  80  


Ser Val Ser Leu Leu Val Met Phe Phe Phe Phe Asp Ser Val Gln Val 
                85                  90                  95      


Val Phe Thr Ile Cys Thr Ala Val Leu Ala Thr Ile Ala Phe Ala Phe 
            100                 105                 110         


Leu Leu Leu Pro Met Cys Gln Tyr Leu Thr Arg Pro Cys Ser Pro Gln 
        115                 120                 125             


Asn Lys Ile Ser Phe Gly Cys Cys Gly Arg Phe Thr Ala Ala Glu Leu 
    130                 135                 140                 


Leu Ser Phe Ser Leu Ser Val Met Leu Val Leu Ile Trp Val Leu Thr 
145                 150                 155                 160 


Gly His Trp Leu Leu Met Asp Ala Leu Ala Met Gly Leu Cys Val Ala 
                165                 170                 175     


Met Ile Ala Phe Val Arg Leu Pro Ser Leu Lys Val Ser Cys Leu Leu 
            180                 185                 190         


Leu Ser Gly Leu Leu Ile Tyr Asp Val Phe Trp Val Phe Phe Ser Ala 
        195                 200                 205             


Tyr Ile Phe Asn Ser Asn Val Met Val Lys Val Ala Thr Gln Pro Ala 
    210                 215                 220                 


Asp Asn Pro Leu Asp Val Leu Ser Arg Lys Leu His Leu Gly Pro Asn 
225                 230                 235                 240 


Val Gly Arg Asp Val Pro Arg Leu Ser Leu Pro Gly Lys Leu Val Phe 
                245                 250                 255     


Pro Ser Ser Thr Gly Ser His Phe Ser Met Leu Gly Ile Gly Asp Ile 
            260                 265                 270         


Val Met Pro Gly Leu Leu Leu Cys Phe Val Leu Arg Tyr Asp Asn Tyr 
        275                 280                 285             


Lys Lys Gln Ala Ser Gly Asp Ser Cys Gly Ala Pro Gly Pro Ala Asn 
    290                 295                 300                 


Ile Ser Gly Arg Met Gln Lys Val Ser Tyr Phe His Cys Thr Leu Ile 
305                 310                 315                 320 


Gly Tyr Phe Val Gly Leu Leu Thr Ala Thr Val Ala Ser Arg Ile His 
                325                 330                 335     


Arg Ala Ala Gln Pro Ala Leu Leu Tyr Leu Val Pro Phe Thr Leu Leu 
            340                 345                 350         


Pro Leu Leu Thr Met Ala Tyr Leu Lys Gly Asp Leu Arg Arg Met Trp 
        355                 360                 365             


Ser Glu Pro Phe His Ser Lys Ser Ser Ser Ser Arg Phe Leu Glu Val 
    370                 375                 380                 


<210>  5826
<211>  764
<212>  PRT
<213>  Homo sapiens

<400>  5826

Met Cys Ile Arg Gln Leu Lys Phe Phe Thr Thr Ala Cys Val Cys Glu 
1               5                   10                  15      


Cys Pro Gln Asn Ile Leu Ser Pro Gln Pro Ser Cys Val Asn Leu Gly 
            20                  25                  30          


Met Met Trp Thr Trp Ala Leu Trp Met Leu Pro Ser Leu Cys Lys Phe 
        35                  40                  45              


Ser Leu Ala Ala Leu Pro Ala Lys Pro Glu Asn Ile Ser Cys Val Tyr 
    50                  55                  60                  


Tyr Tyr Arg Lys Asn Leu Thr Cys Thr Trp Ser Pro Gly Lys Glu Thr 
65                  70                  75                  80  


Ser Tyr Thr Gln Tyr Thr Val Lys Arg Thr Tyr Ala Phe Gly Glu Lys 
                85                  90                  95      


His Asp Asn Cys Thr Thr Asn Ser Ser Thr Ser Glu Asn Arg Ala Ser 
            100                 105                 110         


Cys Ser Phe Phe Leu Pro Arg Ile Thr Ile Pro Asp Asn Tyr Thr Ile 
        115                 120                 125             


Glu Val Glu Ala Glu Asn Gly Asp Gly Val Ile Lys Ser His Met Thr 
    130                 135                 140                 


Tyr Trp Arg Leu Glu Asn Ile Ala Lys Thr Glu Pro Pro Lys Ile Phe 
145                 150                 155                 160 


Arg Val Lys Pro Val Leu Gly Ile Lys Arg Met Ile Gln Ile Glu Trp 
                165                 170                 175     


Ile Lys Pro Glu Leu Ala Pro Val Ser Ser Asp Leu Lys Tyr Thr Leu 
            180                 185                 190         


Arg Phe Arg Thr Val Asn Ser Thr Ser Trp Met Glu Val Asn Phe Ala 
        195                 200                 205             


Lys Asn Arg Lys Asp Lys Asn Gln Thr Tyr Asn Leu Thr Gly Leu Gln 
    210                 215                 220                 


Pro Phe Thr Glu Tyr Val Ile Ala Leu Arg Cys Ala Val Lys Glu Ser 
225                 230                 235                 240 


Lys Phe Trp Ser Asp Trp Ser Gln Glu Lys Met Gly Met Thr Glu Glu 
                245                 250                 255     


Glu Ala Pro Cys Gly Leu Glu Leu Trp Arg Val Leu Lys Pro Ala Glu 
            260                 265                 270         


Ala Asp Gly Arg Arg Pro Val Arg Leu Leu Trp Lys Lys Ala Arg Gly 
        275                 280                 285             


Ala Pro Val Leu Glu Lys Thr Leu Gly Tyr Asn Ile Trp Tyr Tyr Pro 
    290                 295                 300                 


Glu Ser Asn Thr Asn Leu Thr Glu Thr Met Asn Thr Thr Asn Gln Gln 
305                 310                 315                 320 


Leu Glu Leu His Leu Gly Gly Glu Ser Phe Trp Val Ser Met Ile Ser 
                325                 330                 335     


Tyr Asn Ser Leu Gly Lys Ser Pro Val Ala Thr Leu Arg Ile Pro Ala 
            340                 345                 350         


Ile Gln Glu Lys Ser Phe Gln Cys Ile Glu Val Met Gln Ala Cys Val 
        355                 360                 365             


Ala Glu Asp Gln Leu Val Val Lys Trp Gln Ser Ser Ala Leu Asp Val 
    370                 375                 380                 


Asn Thr Trp Met Ile Glu Trp Phe Pro Asp Val Asp Ser Glu Pro Thr 
385                 390                 395                 400 


Thr Leu Ser Trp Glu Ser Val Ser Gln Ala Thr Asn Trp Thr Ile Gln 
                405                 410                 415     


Gln Asp Lys Leu Lys Pro Phe Trp Cys Tyr Asn Ile Ser Val Tyr Pro 
            420                 425                 430         


Met Leu His Asp Lys Val Gly Glu Pro Tyr Ser Ile Gln Ala Tyr Ala 
        435                 440                 445             


Lys Glu Gly Val Pro Ser Glu Gly Pro Glu Thr Lys Val Glu Asn Ile 
    450                 455                 460                 


Gly Val Lys Thr Val Thr Ile Thr Trp Lys Glu Ile Pro Lys Ser Glu 
465                 470                 475                 480 


Arg Lys Gly Ile Ile Cys Asn Tyr Thr Ile Phe Tyr Gln Ala Glu Gly 
                485                 490                 495     


Gly Lys Gly Phe Ser Lys Thr Val Asn Ser Ser Ile Leu Gln Tyr Gly 
            500                 505                 510         


Leu Glu Ser Leu Lys Arg Lys Thr Ser Tyr Ile Val Gln Val Met Ala 
        515                 520                 525             


Ser Thr Ser Ala Gly Gly Thr Asn Gly Thr Ser Ile Asn Phe Lys Thr 
    530                 535                 540                 


Leu Ser Phe Ser Val Phe Glu Ile Ile Leu Ile Thr Ser Leu Ile Gly 
545                 550                 555                 560 


Gly Gly Leu Leu Ile Leu Ile Ile Leu Thr Val Ala Tyr Gly Leu Lys 
                565                 570                 575     


Lys Pro Asn Lys Leu Thr His Leu Cys Trp Pro Thr Val Pro Asn Pro 
            580                 585                 590         


Ala Glu Ser Ser Ile Ala Thr Trp His Gly Asp Asp Phe Lys Asp Lys 
        595                 600                 605             


Leu Asn Leu Lys Glu Ser Asp Asp Ser Val Asn Thr Glu Asp Arg Ile 
    610                 615                 620                 


Leu Lys Pro Cys Ser Thr Pro Ser Asp Lys Leu Val Ile Asp Lys Leu 
625                 630                 635                 640 


Val Val Asn Phe Gly Asn Val Leu Gln Glu Ile Phe Thr Asp Glu Ala 
                645                 650                 655     


Arg Thr Gly Gln Glu Asn Asn Leu Gly Gly Glu Lys Asn Gly Tyr Val 
            660                 665                 670         


Thr Cys Pro Phe Arg Pro Asp Cys Pro Leu Gly Lys Ser Phe Glu Glu 
        675                 680                 685             


Leu Pro Val Ser Pro Glu Ile Pro Pro Arg Lys Ser Gln Tyr Leu Arg 
    690                 695                 700                 


Ser Arg Met Pro Glu Gly Thr Arg Pro Glu Ala Lys Glu Gln Leu Leu 
705                 710                 715                 720 


Phe Ser Gly Gln Ser Leu Val Pro Asp His Leu Cys Glu Glu Gly Ala 
                725                 730                 735     


Pro Asn Pro Tyr Leu Lys Asn Ser Val Thr Ala Arg Glu Phe Leu Val 
            740                 745                 750         


Ser Glu Lys Leu Pro Glu His Thr Lys Gly Glu Val 
        755                 760                 


<210>  5827
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  5827

Met Pro Leu Leu Thr Leu Tyr Leu Leu Leu Phe Trp Leu Ser Gly Tyr 
1               5                   10                  15      


Ser Ile Val Thr Gln Ile Thr Gly Pro Thr Thr Val Asn Gly Leu Glu 
            20                  25                  30          


Arg Gly Ser Leu Thr Val Gln Cys Val Tyr Arg Ser Gly Trp Glu Thr 
        35                  40                  45              


Tyr Leu Lys Trp Trp Cys Arg Gly Ala Ile Trp Arg Asp Cys Lys Ile 
    50                  55                  60                  


Leu Val Lys Thr Ser Gly Ser Glu Gln Glu Val Lys Arg Asp Arg Val 
65                  70                  75                  80  


Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr Phe Thr Val Thr Met Glu 
                85                  90                  95      


Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr Trp Cys Gly Ile Glu Lys 
            100                 105                 110         


Thr Gly Asn Asp Leu Gly Val Thr Val Gln Val Thr Ile Asp Pro Ala 
        115                 120                 125             


Pro Val Thr Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu Thr Gly His 
    130                 135                 140                 


His Leu Asp Asn Arg His Lys Leu Leu Lys Leu Ser Val Leu Leu Pro 
145                 150                 155                 160 


Leu Ile Phe Thr Ile Leu Leu Leu Leu Leu Val Ala Ala Ser Leu Leu 
                165                 170                 175     


Ala Trp Arg Met Met Lys Tyr Gln Gln Lys Ala Ala Gly Met Ser Pro 
            180                 185                 190         


Glu Gln Val Leu Gln Pro Leu Glu Gly Asp Leu Cys Tyr Ala Asp Leu 
        195                 200                 205             


Thr Leu Gln Leu Ala Gly Thr Ser Pro Gln Lys Ala Thr Thr Lys Leu 
    210                 215                 220                 


Ser Ser Ala Gln Val Asp Gln Val Glu Val Glu Tyr Val Thr Met Ala 
225                 230                 235                 240 


Ser Leu Pro Lys Glu Asp Ile Ser Tyr Ala Ser Leu Thr Leu Gly Ala 
                245                 250                 255     


Glu Asp Gln Glu Pro Thr Tyr Cys Asn Met Gly His Leu Ser Ser His 
            260                 265                 270         


Leu Pro Gly Arg Gly Pro Glu Glu Pro Thr Glu Tyr Ser Thr Ile Ser 
        275                 280                 285             


Arg Pro 
    290 


<210>  5828
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  5828

Met Gly Pro Trp Ser Arg Val Arg Val Ala Lys Cys Gln Met Leu Val 
1               5                   10                  15      


Thr Cys Phe Phe Ile Leu Leu Leu Gly Leu Ser Val Ala Thr Met Val 
            20                  25                  30          


Thr Leu Thr Tyr Phe Gly Ala His Phe Ala Val Ile Arg Arg Ala Ser 
        35                  40                  45              


Leu Glu Lys Asn Pro Tyr Gln Ala Val His Gln Trp Ala Phe Ser Ala 
    50                  55                  60                  


Gly Leu Ser Leu Val Gly Leu Leu Thr Leu Gly Ala Val Leu Ser Ala 
65                  70                  75                  80  


Ala Ala Thr Val Arg Glu Ala Gln Gly Leu Met Ala Gly Gly Phe Leu 
                85                  90                  95      


Cys Phe Ser Leu Ala Phe Cys Ala Gln Val Gln Val Val Phe Trp Arg 
            100                 105                 110         


Leu His Ser Pro Thr Gln Val Glu Asp Ala Met Leu Asp Thr Tyr Asp 
        115                 120                 125             


Leu Val Tyr Glu Gln Ala Met Lys Gly Thr Ser His Val Arg Arg Gln 
    130                 135                 140                 


Glu Leu Ala Ala Ile Gln Asp Val Phe Leu Cys Cys Gly Lys Lys Ser 
145                 150                 155                 160 


Pro Phe Ser Arg Leu Gly Ser Thr Glu Ala Asp Leu Cys Gln Gly Glu 
                165                 170                 175     


Glu Ala Ala Arg Glu Asp Cys Leu Gln Gly Ile Arg Ser Phe Leu Arg 
            180                 185                 190         


Thr His Gln Gln Val Ala Ser Ser Leu Thr Ser Ile Gly Leu Ala Leu 
        195                 200                 205             


Thr Val Ser Ala Leu Leu Phe Ser Ser Phe Leu Trp Phe Ala Ile Arg 
    210                 215                 220                 


Cys Gly Cys Ser Leu Asp Arg Lys Gly Lys Tyr Thr Leu Thr Pro Arg 
225                 230                 235                 240 


Ala Cys Gly Arg Gln Pro Gln Glu Pro Ser Leu Leu Arg Cys Ser Gln 
                245                 250                 255     


Gly Gly Pro Thr His Cys Leu His Ser Glu Ala Val Ala Ile Gly Pro 
            260                 265                 270         


Arg Gly Cys Ser Gly Ser Leu Arg Trp Leu Gln Glu Ser Asp Ala Ala 
        275                 280                 285             


Pro Leu Pro Leu Ser Cys His Leu Ala Ala His Arg Ala Leu Gln Gly 
    290                 295                 300                 


Arg Ser Arg Gly Gly Leu Ser Gly Cys Pro Glu Arg Gly Leu Ser Asp 
305                 310                 315                 320 


<210>  5829
<211>  1427
<212>  PRT
<213>  Homo sapiens

<400>  5829

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr 
    1415                 1420                 1425         


<210>  5830
<211>  1340
<212>  PRT
<213>  Homo sapiens

<400>  5830

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala 
        275                 280                 285             


Val Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu 
    290                 295                 300                 


Ser Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu 
305                 310                 315                 320 


Val Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser 
                325                 330                 335     


Lys Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val 
            340                 345                 350         


His Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser 
        355                 360                 365             


Cys Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg 
    370                 375                 380                 


Pro Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu 
385                 390                 395                 400 


Met Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser 
                405                 410                 415     


Gln Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly 
            420                 425                 430         


Gly Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly 
        435                 440                 445             


Asp Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile 
    450                 455                 460                 


Met Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser 
465                 470                 475                 480 


Gly Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys 
                485                 490                 495     


Arg Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp 
            500                 505                 510         


Arg Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys 
        515                 520                 525             


Gly Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr 
    530                 535                 540                 


Val Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu 
545                 550                 555                 560 


Phe Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly 
                565                 570                 575     


Lys Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp 
            580                 585                 590         


Gly Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg 
        595                 600                 605             


Leu Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile 
    610                 615                 620                 


Gln Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro 
625                 630                 635                 640 


Asp Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val 
                645                 650                 655     


Trp Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu 
            660                 665                 670         


Arg Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val 
        675                 680                 685             


Glu Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu 
    690                 695                 700                 


Ala Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe 
705                 710                 715                 720 


Gly Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val 
                725                 730                 735     


Arg Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala 
            740                 745                 750         


Arg Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys 
        755                 760                 765             


Asn Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser 
    770                 775                 780                 


Cys Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys 
785                 790                 795                 800 


Val Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly 
                805                 810                 815     


Ser Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser 
            820                 825                 830         


Cys Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys 
        835                 840                 845             


Ala Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His 
    850                 855                 860                 


Val Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly 
865                 870                 875                 880 


Leu Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro 
                885                 890                 895     


Val Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg 
            900                 905                 910         


Glu Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu 
        915                 920                 925             


Ala Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu 
    930                 935                 940                 


Tyr Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu 
945                 950                 955                 960 


Asp Thr Gln Cys Gln Gly Leu Pro Arg Pro Glu Pro Gln Glu Ala Cys 
                965                 970                 975     


Ser Leu Glu Pro Cys Pro Pro Arg Trp Lys Val Met Ser Leu Gly Pro 
            980                 985                 990         


Cys Ser Ala Ser Cys Gly Leu Gly  Thr Ala Arg Arg Ser  Val Ala Cys 
        995                 1000                 1005             


Val Gln  Leu Asp Gln Gly Gln  Asp Val Glu Val Asp  Glu Ala Ala 
    1010                 1015                 1020             


Cys Ala  Ala Leu Val Arg Pro  Glu Ala Ser Val Pro  Cys Leu Ile 
    1025                 1030                 1035             


Ala Asp  Cys Thr Tyr Arg Trp  His Val Gly Thr Trp  Met Glu Cys 
    1040                 1045                 1050             


Ser Val  Ser Cys Gly Asp Gly  Ile Gln Arg Arg Arg  Asp Thr Cys 
    1055                 1060                 1065             


Leu Gly  Pro Gln Ala Gln Ala  Pro Val Pro Ala Asp  Phe Cys Gln 
    1070                 1075                 1080             


His Leu  Pro Lys Pro Val Thr  Val Arg Gly Cys Trp  Ala Gly Pro 
    1085                 1090                 1095             


Cys Val  Gly Gln Gly Ala Cys  Gly Arg Gln His Leu  Glu Pro Thr 
    1100                 1105                 1110             


Gly Thr  Ile Asp Met Arg Gly  Pro Gly Gln Ala Asp  Cys Ala Val 
    1115                 1120                 1125             


Ala Ile  Gly Arg Pro Leu Gly  Glu Val Val Thr Leu  Arg Val Leu 
    1130                 1135                 1140             


Glu Ser  Ser Leu Asn Cys Ser  Ala Gly Asp Met Leu  Leu Leu Trp 
    1145                 1150                 1155             


Gly Arg  Leu Thr Trp Arg Lys  Met Cys Arg Lys Leu  Leu Asp Met 
    1160                 1165                 1170             


Thr Phe  Ser Ser Lys Thr Asn  Thr Leu Val Val Arg  Gln Arg Cys 
    1175                 1180                 1185             


Gly Arg  Pro Gly Gly Gly Val  Leu Leu Arg Tyr Gly  Ser Gln Leu 
    1190                 1195                 1200             


Ala Pro  Glu Thr Phe Tyr Arg  Glu Cys Asp Met Gln  Leu Phe Gly 
    1205                 1210                 1215             


Pro Trp  Gly Glu Ile Val Ser  Pro Ser Leu Ser Pro  Ala Thr Ser 
    1220                 1225                 1230             


Asn Ala  Gly Gly Cys Arg Leu  Phe Ile Asn Val Ala  Pro His Ala 
    1235                 1240                 1245             


Arg Ile  Ala Ile His Ala Leu  Ala Thr Asn Met Gly  Ala Gly Thr 
    1250                 1255                 1260             


Glu Gly  Ala Asn Ala Ser Tyr  Ile Leu Ile Arg Asp  Thr His Ser 
    1265                 1270                 1275             


Leu Arg  Thr Thr Ala Phe His  Gly Gln Gln Val Leu  Tyr Trp Glu 
    1280                 1285                 1290             


Ser Glu  Ser Ser Gln Ala Glu  Met Glu Phe Ser Glu  Gly Phe Leu 
    1295                 1300                 1305             


Lys Ala  Gln Ala Ser Leu Arg  Gly Gln Tyr Trp Thr  Leu Gln Ser 
    1310                 1315                 1320             


Trp Val  Pro Glu Met Gln Asp  Pro Gln Ser Trp Lys  Gly Lys Glu 
    1325                 1330                 1335             


Gly Thr  
    1340 


<210>  5831
<211>  1371
<212>  PRT
<213>  Homo sapiens

<400>  5831

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Ala  Cys Gly Arg Gln His  Leu Glu Pro 
    1130                 1135                 1140             


Thr Gly  Thr Ile Asp Met Arg  Gly Pro Gly Gln Ala  Asp Cys Ala 
    1145                 1150                 1155             


Val Ala  Ile Gly Arg Pro Leu  Gly Glu Val Val Thr  Leu Arg Val 
    1160                 1165                 1170             


Leu Glu  Ser Ser Leu Asn Cys  Ser Ala Gly Asp Met  Leu Leu Leu 
    1175                 1180                 1185             


Trp Gly  Arg Leu Thr Trp Arg  Lys Met Cys Arg Lys  Leu Leu Asp 
    1190                 1195                 1200             


Met Thr  Phe Ser Ser Lys Thr  Asn Thr Leu Val Val  Arg Gln Arg 
    1205                 1210                 1215             


Cys Gly  Arg Pro Gly Gly Gly  Val Leu Leu Arg Tyr  Gly Ser Gln 
    1220                 1225                 1230             


Leu Ala  Pro Glu Thr Phe Tyr  Arg Glu Cys Asp Met  Gln Leu Phe 
    1235                 1240                 1245             


Gly Pro  Trp Gly Glu Ile Val  Ser Pro Ser Leu Ser  Pro Ala Thr 
    1250                 1255                 1260             


Ser Asn  Ala Gly Gly Cys Arg  Leu Phe Ile Asn Val  Ala Pro His 
    1265                 1270                 1275             


Ala Arg  Ile Ala Ile His Ala  Leu Ala Thr Asn Met  Gly Ala Gly 
    1280                 1285                 1290             


Thr Glu  Gly Ala Asn Ala Ser  Tyr Ile Leu Ile Arg  Asp Thr His 
    1295                 1300                 1305             


Ser Leu  Arg Thr Thr Ala Phe  His Gly Gln Gln Val  Leu Tyr Trp 
    1310                 1315                 1320             


Glu Ser  Glu Ser Ser Gln Ala  Glu Met Glu Phe Ser  Glu Gly Phe 
    1325                 1330                 1335             


Leu Lys  Ala Gln Ala Ser Leu  Arg Gly Gln Tyr Trp  Thr Leu Gln 
    1340                 1345                 1350             


Ser Trp  Val Pro Glu Met Gln  Asp Pro Gln Ser Trp  Lys Gly Lys 
    1355                 1360                 1365             


Glu Gly  Thr 
    1370     


<210>  5832
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  5832

Met Gly Glu Phe Asn Glu Lys Lys Thr Thr Cys Gly Thr Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Thr Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Thr Tyr Leu Ala Thr Ala Tyr Ile Leu 
    50                  55                  60                  


Val Val Ala Gly Thr Val Val Met Val Thr Gly Val Leu Gly Cys Cys 
65                  70                  75                  80  


Ala Thr Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu 
                85                  90                  95      


Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr 
            100                 105                 110         


Ala Tyr Tyr Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu Lys Asp 
        115                 120                 125             


Thr Met Thr Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Thr Ser 
    130                 135                 140                 


Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn 
145                 150                 155                 160 


Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly 
                165                 170                 175     


Gly Arg Val Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala Leu Cys 
            180                 185                 190         


Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly Gly Cys 
        195                 200                 205             


Ile Thr Lys Leu Glu Thr Phe Ile Gln Glu His Leu Arg Val Ile Gly 
    210                 215                 220                 


Ala Val Gly Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met Ile Phe 
225                 230                 235                 240 


Thr Cys Cys Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr 
                245                 250             


<210>  5833
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  5833

Met Gly Glu Phe Asn Glu Lys Lys Thr Thr Cys Gly Thr Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Thr Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Thr Tyr Leu Ala Thr Ala Tyr Ile Leu 
    50                  55                  60                  


Val Val Ala Gly Thr Val Val Met Val Thr Gly Val Leu Gly Cys Cys 
65                  70                  75                  80  


Ala Thr Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu 
                85                  90                  95      


Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr 
            100                 105                 110         


Ala Tyr Tyr Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu Lys Asp 
        115                 120                 125             


Thr Met Thr Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Thr Ser 
    130                 135                 140                 


Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn 
145                 150                 155                 160 


Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly 
                165                 170                 175     


Gly Arg Val Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala Leu Cys 
            180                 185                 190         


Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly Gly Cys 
        195                 200                 205             


Ile Thr Lys Leu Glu Thr Phe Ile Gln Glu His Leu Arg Val Ile Gly 
    210                 215                 220                 


Ala Val Gly Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met Ile Phe 
225                 230                 235                 240 


Thr Cys Cys Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr 
                245                 250             


<210>  5834
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  5834

Met Lys Lys Val Lys Lys Lys Arg Ser Glu Ala Arg Arg His Arg Asp 
1               5                   10                  15      


Ser Thr Ser Gln His Ala Ser Ser Asn Ser Thr Ser Gln Gln Pro Ser 
            20                  25                  30          


Pro Glu Ser Thr Pro Gln Gln Pro Ser Pro Glu Ser Thr Pro Gln Gln 
        35                  40                  45              


Pro Ser Pro Glu Ser Thr Pro Gln His Ser Ser Leu Glu Thr Thr Ser 
    50                  55                  60                  


Arg Gln Pro Ala Phe Gln Ala Leu Pro Ala Pro Glu Ile Arg Arg Ser 
65                  70                  75                  80  


Ser Cys Cys Leu Leu Ser Pro Asp Ala Asn Val Lys Ala Ala Pro Gln 
                85                  90                  95      


Ser Arg Lys Ala Gly Pro Leu Ile Arg Ala Gly Pro His Ser Cys Ser 
            100                 105                 110         


Cys Ala Thr Cys Pro Cys Ser Ser Ala Cys Trp Arg Arg Leu Gly Leu 
        115                 120                 125             


Cys His Ser Arg Ile Phe Asp Val Leu Leu Pro Arg Asp Trp Gln Met 
    130                 135                 140                 


Ala Pro Gly Arg Gly Leu Pro Asn Leu Leu Thr Phe Tyr Arg Lys Ser 
145                 150                 155                 160 


Ser Arg Lys Pro Ser Ser His Arg Asn Ala Cys Pro Pro Ser Pro Arg 
                165                 170                 175     


Asn Cys Gly Cys Gly Ser Gly Gly Ser Arg Ser Cys Leu Leu His His 
            180                 185                 190         


<210>  5835
<211>  752
<212>  PRT
<213>  Homo sapiens

<400>  5835

Met Ala Glu Pro Gln Ala Glu Ser Glu Pro Leu Leu Gly Gly Ala Arg 
1               5                   10                  15      


Gly Gly Gly Gly Asp Trp Pro Ala Gly Leu Thr Thr Tyr Arg Ser Ile 
            20                  25                  30          


Gln Val Gly Pro Gly Ala Ala Ala Arg Trp Asp Leu Cys Ile Asp Gln 
        35                  40                  45              


Ala Val Val Phe Ile Glu Asp Ala Ile Gln Tyr Arg Ser Ile Asn His 
    50                  55                  60                  


Arg Val Asp Ala Ser Ser Met Trp Leu Tyr Arg Arg Tyr Tyr Ser Asn 
65                  70                  75                  80  


Val Cys Gln Arg Thr Leu Ser Phe Thr Ile Phe Leu Ile Leu Phe Leu 
                85                  90                  95      


Ala Phe Ile Glu Thr Pro Ser Ser Leu Thr Ser Thr Ala Asp Val Arg 
            100                 105                 110         


Tyr Arg Ala Ala Pro Trp Glu Pro Pro Cys Gly Leu Thr Glu Ser Val 
        115                 120                 125             


Glu Val Leu Cys Leu Leu Val Phe Ala Ala Asp Leu Ser Val Lys Gly 
    130                 135                 140                 


Tyr Leu Phe Gly Trp Ala His Phe Gln Lys Asn Leu Trp Leu Leu Gly 
145                 150                 155                 160 


Tyr Leu Val Val Leu Val Val Ser Leu Val Asp Trp Thr Val Ser Leu 
                165                 170                 175     


Ser Leu Val Cys His Glu Pro Leu Arg Ile Arg Arg Leu Leu Arg Pro 
            180                 185                 190         


Phe Phe Leu Leu Gln Asn Ser Ser Met Met Lys Lys Thr Leu Lys Cys 
        195                 200                 205             


Ile Arg Trp Ser Leu Pro Glu Met Ala Ser Val Gly Leu Leu Leu Ala 
    210                 215                 220                 


Ile His Leu Cys Leu Phe Thr Met Phe Gly Met Leu Leu Phe Ala Gly 
225                 230                 235                 240 


Gly Lys Gln Asp Asp Gly Gln Asp Arg Glu Arg Leu Thr Tyr Phe Gln 
                245                 250                 255     


Asn Leu Pro Glu Ser Leu Thr Ser Leu Leu Val Leu Leu Thr Thr Ala 
            260                 265                 270         


Asn Asn Pro Asp Val Met Ile Pro Ala Tyr Ser Lys Asn Arg Ala Tyr 
        275                 280                 285             


Ala Ile Phe Phe Ile Val Phe Thr Val Ile Gly Ser Leu Phe Leu Met 
    290                 295                 300                 


Asn Leu Leu Thr Ala Ile Ile Tyr Ser Gln Phe Arg Gly Tyr Leu Met 
305                 310                 315                 320 


Lys Ser Leu Gln Thr Ser Leu Phe Arg Arg Arg Leu Gly Thr Arg Ala 
                325                 330                 335     


Ala Phe Glu Val Leu Ser Ser Met Val Gly Glu Gly Gly Ala Phe Pro 
            340                 345                 350         


Gln Ala Val Gly Val Lys Pro Gln Asn Leu Leu Gln Val Leu Gln Lys 
        355                 360                 365             


Val Gln Leu Asp Ser Ser His Lys Gln Ala Met Met Glu Lys Val Arg 
    370                 375                 380                 


Ser Tyr Gly Ser Val Leu Leu Ser Ala Glu Glu Phe Gln Lys Leu Phe 
385                 390                 395                 400 


Asn Glu Leu Asp Arg Ser Val Val Lys Glu His Pro Pro Arg Pro Glu 
                405                 410                 415     


Tyr Gln Ser Pro Phe Leu Gln Ser Ala Gln Phe Leu Phe Gly His Tyr 
            420                 425                 430         


Tyr Phe Asp Tyr Leu Gly Asn Leu Ile Ala Leu Ala Asn Leu Val Ser 
        435                 440                 445             


Ile Cys Val Phe Leu Val Leu Asp Ala Asp Val Leu Pro Ala Glu Arg 
    450                 455                 460                 


Asp Asp Phe Ile Leu Gly Ile Leu Asn Cys Val Phe Ile Val Tyr Tyr 
465                 470                 475                 480 


Leu Leu Glu Met Leu Leu Lys Val Phe Ala Leu Gly Leu Arg Gly Tyr 
                485                 490                 495     


Leu Ser Tyr Pro Ser Asn Val Phe Asp Gly Leu Leu Thr Val Val Leu 
            500                 505                 510         


Leu Val Leu Glu Ile Ser Thr Leu Ala Val Tyr Arg Leu Pro His Pro 
        515                 520                 525             


Gly Trp Arg Pro Glu Met Val Gly Leu Leu Ser Leu Trp Asp Met Thr 
    530                 535                 540                 


Arg Met Leu Asn Met Leu Ile Val Phe Arg Phe Leu Arg Ile Ile Pro 
545                 550                 555                 560 


Ser Met Lys Leu Met Ala Val Val Ala Ser Thr Val Leu Gly Leu Val 
                565                 570                 575     


Gln Asn Met Arg Ala Phe Gly Gly Ile Leu Val Val Val Tyr Tyr Val 
            580                 585                 590         


Phe Ala Ile Ile Gly Ile Asn Leu Phe Arg Gly Val Ile Val Ala Leu 
        595                 600                 605             


Pro Gly Asn Ser Ser Leu Ala Pro Ala Asn Gly Ser Ala Pro Cys Gly 
    610                 615                 620                 


Ser Phe Glu Gln Leu Glu Tyr Trp Ala Asn Asn Phe Asp Asp Phe Ala 
625                 630                 635                 640 


Ala Ala Leu Val Thr Leu Trp Asn Leu Met Val Val Asn Asn Trp Gln 
                645                 650                 655     


Val Phe Leu Asp Ala Tyr Arg Arg Tyr Ser Gly Pro Trp Ser Lys Ile 
            660                 665                 670         


Tyr Phe Val Leu Trp Trp Leu Val Ser Ser Val Ile Trp Val Asn Leu 
        675                 680                 685             


Phe Leu Ala Leu Ile Leu Glu Asn Phe Leu His Lys Trp Asp Pro Arg 
    690                 695                 700                 


Ser His Leu Gln Pro Leu Ala Gly Thr Pro Glu Ala Thr Tyr Gln Met 
705                 710                 715                 720 


Thr Val Glu Leu Leu Phe Arg Asp Ile Leu Glu Glu Pro Gly Glu Asp 
                725                 730                 735     


Glu Leu Thr Glu Arg Leu Ser Gln His Pro His Leu Trp Leu Cys Arg 
            740                 745                 750         


<210>  5836
<211>  613
<212>  PRT
<213>  Homo sapiens

<400>  5836

Met Gly Lys Ile Glu Asn Asn Glu Arg Val Ile Leu Asn Val Gly Gly 
1               5                   10                  15      


Thr Arg His Glu Thr Tyr Arg Ser Thr Leu Lys Thr Leu Pro Gly Thr 
            20                  25                  30          


Arg Leu Ala Leu Leu Ala Ser Ser Glu Pro Pro Gly Asp Cys Leu Thr 
        35                  40                  45              


Thr Ala Gly Asp Lys Leu Gln Pro Ser Pro Pro Pro Leu Ser Pro Pro 
    50                  55                  60                  


Pro Arg Ala Pro Pro Leu Ser Pro Gly Pro Gly Gly Cys Phe Glu Gly 
65                  70                  75                  80  


Gly Ala Gly Asn Cys Ser Ser Arg Gly Gly Arg Ala Ser Asp His Pro 
                85                  90                  95      


Gly Gly Gly Arg Glu Phe Phe Phe Asp Arg His Pro Gly Val Phe Ala 
            100                 105                 110         


Tyr Val Leu Asn Tyr Tyr Arg Thr Gly Lys Leu His Cys Pro Ala Asp 
        115                 120                 125             


Val Cys Gly Pro Leu Phe Glu Glu Glu Leu Ala Phe Trp Gly Ile Asp 
    130                 135                 140                 


Glu Thr Asp Val Glu Pro Cys Cys Trp Met Thr Tyr Arg Gln His Arg 
145                 150                 155                 160 


Asp Ala Glu Glu Ala Leu Asp Ile Phe Glu Thr Pro Asp Leu Ile Gly 
                165                 170                 175     


Gly Asp Pro Gly Asp Asp Glu Asp Leu Ala Ala Lys Arg Leu Gly Ile 
            180                 185                 190         


Glu Asp Ala Ala Gly Leu Gly Gly Pro Asp Gly Lys Ser Gly Arg Trp 
        195                 200                 205             


Arg Arg Leu Gln Pro Arg Met Trp Ala Leu Phe Glu Asp Pro Tyr Ser 
    210                 215                 220                 


Ser Arg Ala Ala Arg Phe Ile Ala Phe Ala Ser Leu Phe Phe Ile Leu 
225                 230                 235                 240 


Val Ser Ile Thr Thr Phe Cys Leu Glu Thr His Glu Ala Phe Asn Ile 
                245                 250                 255     


Val Lys Asn Lys Thr Glu Pro Val Ile Asn Gly Thr Ser Val Val Leu 
            260                 265                 270         


Gln Tyr Glu Ile Glu Thr Asp Pro Ala Leu Thr Tyr Val Glu Gly Val 
        275                 280                 285             


Cys Val Val Trp Phe Thr Phe Glu Phe Leu Val Arg Ile Val Phe Ser 
    290                 295                 300                 


Pro Asn Lys Leu Glu Phe Ile Lys Asn Leu Leu Asn Ile Ile Asp Phe 
305                 310                 315                 320 


Val Ala Ile Leu Pro Phe Tyr Leu Glu Val Gly Leu Ser Gly Leu Ser 
                325                 330                 335     


Ser Lys Ala Ala Lys Asp Val Leu Gly Phe Leu Arg Val Val Arg Phe 
            340                 345                 350         


Val Arg Ile Leu Arg Ile Phe Lys Leu Thr Arg His Phe Val Gly Leu 
        355                 360                 365             


Arg Val Leu Gly His Thr Leu Arg Ala Ser Thr Asn Glu Phe Leu Leu 
    370                 375                 380                 


Leu Ile Ile Phe Leu Ala Leu Gly Val Leu Ile Phe Ala Thr Met Ile 
385                 390                 395                 400 


Tyr Tyr Ala Glu Arg Val Gly Ala Gln Pro Asn Asp Pro Ser Ala Ser 
                405                 410                 415     


Glu His Thr Gln Phe Lys Asn Ile Pro Ile Gly Phe Trp Trp Ala Val 
            420                 425                 430         


Val Thr Met Thr Thr Leu Gly Tyr Gly Asp Met Tyr Pro Gln Thr Trp 
        435                 440                 445             


Ser Gly Met Leu Val Gly Ala Leu Cys Ala Leu Ala Gly Val Leu Thr 
    450                 455                 460                 


Ile Ala Met Pro Val Pro Val Ile Val Asn Asn Phe Gly Met Tyr Tyr 
465                 470                 475                 480 


Ser Leu Ala Met Ala Lys Gln Lys Leu Pro Arg Lys Arg Lys Lys His 
                485                 490                 495     


Ile Pro Pro Ala Pro Gln Ala Ser Ser Pro Thr Phe Cys Lys Thr Glu 
            500                 505                 510         


Leu Asn Met Ala Cys Asn Ser Thr Gln Ser Asp Thr Cys Leu Gly Lys 
        515                 520                 525             


Asp Asn Arg Leu Leu Glu His Asn Arg Ser Val Leu Ser Gly Asp Asp 
    530                 535                 540                 


Ser Thr Gly Ser Glu Pro Pro Leu Ser Pro Pro Glu Arg Leu Pro Ile 
545                 550                 555                 560 


Arg Arg Ser Ser Thr Arg Asp Lys Asn Arg Arg Gly Glu Thr Cys Phe 
                565                 570                 575     


Leu Leu Thr Thr Gly Asp Tyr Thr Cys Ala Ser Asp Gly Gly Ile Arg 
            580                 585                 590         


Lys Asp Asn Cys Lys Glu Val Val Ile Thr Gly Tyr Thr Gln Ala Glu 
        595                 600                 605             


Ala Arg Ser Leu Thr 
    610             


<210>  5837
<211>  638
<212>  PRT
<213>  Homo sapiens

<400>  5837

Met Gly Lys Ile Glu Asn Asn Glu Arg Val Ile Leu Asn Val Gly Gly 
1               5                   10                  15      


Thr Arg His Glu Thr Tyr Arg Ser Thr Leu Lys Thr Leu Pro Gly Thr 
            20                  25                  30          


Arg Leu Ala Leu Leu Ala Ser Ser Glu Pro Pro Gly Asp Cys Leu Thr 
        35                  40                  45              


Thr Ala Gly Asp Lys Leu Gln Pro Ser Pro Pro Pro Leu Ser Pro Pro 
    50                  55                  60                  


Pro Arg Ala Pro Pro Leu Ser Pro Gly Pro Gly Gly Cys Phe Glu Gly 
65                  70                  75                  80  


Gly Ala Gly Asn Cys Ser Ser Arg Gly Gly Arg Ala Ser Asp His Pro 
                85                  90                  95      


Gly Gly Gly Arg Glu Phe Phe Phe Asp Arg His Pro Gly Val Phe Ala 
            100                 105                 110         


Tyr Val Leu Asn Tyr Tyr Arg Thr Gly Lys Leu His Cys Pro Ala Asp 
        115                 120                 125             


Val Cys Gly Pro Leu Phe Glu Glu Glu Leu Ala Phe Trp Gly Ile Asp 
    130                 135                 140                 


Glu Thr Asp Val Glu Pro Cys Cys Trp Met Thr Tyr Arg Gln His Arg 
145                 150                 155                 160 


Asp Ala Glu Glu Ala Leu Asp Ile Phe Glu Thr Pro Asp Leu Ile Gly 
                165                 170                 175     


Gly Asp Pro Gly Asp Asp Glu Asp Leu Ala Ala Lys Arg Leu Gly Ile 
            180                 185                 190         


Glu Asp Ala Ala Gly Leu Gly Gly Pro Asp Gly Lys Ser Gly Arg Trp 
        195                 200                 205             


Arg Arg Leu Gln Pro Arg Met Trp Ala Leu Phe Glu Asp Pro Tyr Ser 
    210                 215                 220                 


Ser Arg Ala Ala Arg Phe Ile Ala Phe Ala Ser Leu Phe Phe Ile Leu 
225                 230                 235                 240 


Val Ser Ile Thr Thr Phe Cys Leu Glu Thr His Glu Ala Phe Asn Ile 
                245                 250                 255     


Val Lys Asn Lys Thr Glu Pro Val Ile Asn Gly Thr Ser Val Val Leu 
            260                 265                 270         


Gln Tyr Glu Ile Glu Thr Asp Pro Ala Leu Thr Tyr Val Glu Gly Val 
        275                 280                 285             


Cys Val Val Trp Phe Thr Phe Glu Phe Leu Val Arg Ile Val Phe Ser 
    290                 295                 300                 


Pro Asn Lys Leu Glu Phe Ile Lys Asn Leu Leu Asn Ile Ile Asp Phe 
305                 310                 315                 320 


Val Ala Ile Leu Pro Phe Tyr Leu Glu Val Gly Leu Ser Gly Leu Ser 
                325                 330                 335     


Ser Lys Ala Ala Lys Asp Val Leu Gly Phe Leu Arg Val Val Arg Phe 
            340                 345                 350         


Val Arg Ile Leu Arg Ile Phe Lys Leu Thr Arg His Phe Val Gly Leu 
        355                 360                 365             


Arg Val Leu Gly His Thr Leu Arg Ala Ser Thr Asn Glu Phe Leu Leu 
    370                 375                 380                 


Leu Ile Ile Phe Leu Ala Leu Gly Val Leu Ile Phe Ala Thr Met Ile 
385                 390                 395                 400 


Tyr Tyr Ala Glu Arg Val Gly Ala Gln Pro Asn Asp Pro Ser Ala Ser 
                405                 410                 415     


Glu His Thr Gln Phe Lys Asn Ile Pro Ile Gly Phe Trp Trp Ala Val 
            420                 425                 430         


Val Thr Met Thr Thr Leu Gly Tyr Gly Asp Met Tyr Pro Gln Thr Trp 
        435                 440                 445             


Ser Gly Met Leu Val Gly Ala Leu Cys Ala Leu Ala Gly Val Leu Thr 
    450                 455                 460                 


Ile Ala Met Pro Val Pro Val Ile Val Asn Asn Phe Gly Met Tyr Tyr 
465                 470                 475                 480 


Ser Leu Ala Met Ala Lys Gln Lys Leu Pro Arg Lys Arg Lys Lys His 
                485                 490                 495     


Ile Pro Pro Ala Pro Gln Ala Ser Ser Pro Thr Phe Cys Lys Thr Glu 
            500                 505                 510         


Leu Asn Met Ala Cys Asn Ser Thr Gln Ser Asp Thr Cys Leu Gly Lys 
        515                 520                 525             


Asp Asn Arg Leu Leu Glu His Asn Arg Ser Val Leu Ser Gly Asp Asp 
    530                 535                 540                 


Ser Thr Gly Ser Glu Pro Pro Leu Ser Pro Pro Glu Arg Leu Pro Ile 
545                 550                 555                 560 


Arg Arg Ser Ser Thr Arg Asp Lys Asn Arg Arg Gly Glu Thr Cys Phe 
                565                 570                 575     


Leu Leu Thr Thr Gly Asp Tyr Thr Cys Ala Ser Asp Gly Gly Ile Arg 
            580                 585                 590         


Lys Gly Tyr Glu Lys Ser Arg Ser Leu Asn Asn Ile Ala Gly Leu Ala 
        595                 600                 605             


Gly Asn Ala Leu Arg Leu Ser Pro Val Thr Ser Pro Tyr Asn Ser Pro 
    610                 615                 620                 


Cys Pro Leu Arg Arg Ser Arg Ser Pro Ile Pro Ser Ile Leu 
625                 630                 635             


<210>  5838
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  5838

Met Ala Asn Pro Gly Leu Gly Leu Leu Leu Ala Leu Gly Leu Pro Phe 
1               5                   10                  15      


Leu Leu Ala Arg Trp Gly Arg Ala Trp Gly Gln Ile Gln Thr Thr Ser 
            20                  25                  30          


Ala Asn Glu Asn Ser Thr Val Leu Pro Ser Ser Thr Ser Ser Ser Ser 
        35                  40                  45              


Asp Gly Asn Leu Arg Pro Glu Ala Ile Thr Ala Ile Ile Val Val Phe 
    50                  55                  60                  


Ser Leu Leu Ala Ala Leu Leu Leu Ala Val Gly Leu Ala Leu Leu Val 
65                  70                  75                  80  


Arg Lys Leu Arg Glu Lys Arg Gln Thr Glu Gly Thr Tyr Arg Pro Ser 
                85                  90                  95      


Ser Glu Glu Gln Val Gly Ala Arg Val Pro Pro Thr Pro Asn Leu Lys 
            100                 105                 110         


Leu Pro Pro Glu Glu Arg Leu Ile 
        115                 120 


<210>  5839
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  5839

Met Ala Glu Phe Ser Gln Lys Arg Gly Lys Arg Arg Ser Asp Glu Gly 
1               5                   10                  15      


Leu Gly Ser Met Val Asp Phe Leu Leu Ala Asn Ala Arg Leu Val Leu 
            20                  25                  30          


Gly Val Gly Gly Ala Ala Val Leu Gly Ile Ala Thr Leu Ala Val Lys 
        35                  40                  45              


Arg Phe Ile Asp Arg Ala Thr Ser Pro Arg Asp Glu Asp Asp Thr Lys 
    50                  55                  60                  


Ala Asp Ser Trp Lys Glu Leu Ser Leu Leu Lys Ala Thr Pro His Leu 
65                  70                  75                  80  


Gln Pro Arg Pro Pro Pro Ala Ala Leu Ser Gln Pro Val Leu Pro Leu 
                85                  90                  95      


Ala Pro Ser Ser Ser Ala Pro Glu Gly Pro Ala Glu Thr Asp Pro Glu 
            100                 105                 110         


Val Thr Pro Gln Leu Ser Ser Pro Ala Pro Leu Cys Leu Thr Leu Gln 
        115                 120                 125             


Glu Arg Leu Leu Ala Phe Glu Arg Asp Arg Val Thr Ile Pro Ala Ala 
    130                 135                 140                 


Gln Val Ala Leu Ala Lys Gln Leu Ala Gly Asp Ile Ala Leu Glu Leu 
145                 150                 155                 160 


Gln Ala Tyr Phe Arg Ser Lys Phe Pro Glu Leu Pro Phe Gly Ala Phe 
                165                 170                 175     


Val Pro Gly Gly Pro Leu Tyr Asp Gly Leu Gln Ala Gly Ala Ala Asp 
            180                 185                 190         


His Val Arg Leu Leu Val Pro Leu Val Leu Glu Pro Gly Leu Trp Ser 
        195                 200                 205             


Leu Val Pro Gly Val Asp Thr Val Ala Arg Asp Pro Arg Cys Trp Ala 
    210                 215                 220                 


Val Arg Arg Thr Gln Leu Glu Phe Cys Pro Arg Gly Ser Ser Pro Trp 
225                 230                 235                 240 


Asp Arg Phe Leu Val Gly Gly Tyr Leu Ser Ser Arg Val Leu Leu Glu 
                245                 250                 255     


Leu Leu Arg Lys Ala Leu Ala Ala Ser Val Asn Trp Pro Ala Ile Gly 
            260                 265                 270         


Ser Leu Leu Gly Cys Leu Ile Arg Pro Ser Met Ala Ser Glu Glu Leu 
        275                 280                 285             


Leu Leu Glu Val Gln His Glu Arg Leu Glu Leu Thr Val Ala Val Leu 
    290                 295                 300                 


Val Ala Val Pro Gly Val Asp Ala Asp Asp Arg Leu Leu Leu Ala Trp 
305                 310                 315                 320 


Pro Leu Glu Gly Leu Ala Gly Asn Leu Trp Leu Gln Asp Leu Tyr Pro 
                325                 330                 335     


Val Glu Ala Ala Arg Leu Arg Ala Leu Asp Asp His Asp Ala Gly Thr 
            340                 345                 350         


Arg Arg Arg Leu Leu Leu Leu Leu Cys Ala Val Cys Arg Gly Cys Ser 
        355                 360                 365             


Ala Leu Gly Gln Leu Gly Arg Gly His Leu Thr Gln Val Val Leu Arg 
    370                 375                 380                 


Leu Gly Glu Asp Asn Val Asp Trp Thr Glu Glu Ala Leu Gly Glu Arg 
385                 390                 395                 400 


Phe Leu Gln Ala Leu Glu Leu Leu Ile Gly Ser Leu Glu Gln Ala Ser 
                405                 410                 415     


Leu Pro Cys His Phe Asn Pro Ser Val Asn Leu Phe Ser Ser Leu Arg 
            420                 425                 430         


Glu Glu Glu Ile Asp Asp Ile Gly Tyr Ala Leu Tyr Ser Gly Leu Gln 
        435                 440                 445             


Glu Pro Glu Gly Leu Leu 
    450                 


<210>  5840
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  5840

Met Arg Arg Ile Ser Leu Thr Ser Ser Pro Val Arg Leu Leu Leu Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ile Ala Leu Glu Ile Met Val Gly Gly His Ser 
            20                  25                  30          


Leu Cys Phe Asn Phe Thr Ile Lys Ser Leu Ser Arg Pro Gly Gln Pro 
        35                  40                  45              


Trp Cys Glu Ala Gln Val Phe Leu Asn Lys Asn Leu Phe Leu Gln Tyr 
    50                  55                  60                  


Asn Ser Asp Asn Asn Met Val Lys Pro Leu Gly Leu Leu Gly Lys Lys 
65                  70                  75                  80  


Val Tyr Ala Thr Ser Thr Trp Gly Glu Leu Thr Gln Thr Leu Gly Glu 
                85                  90                  95      


Val Gly Arg Asp Leu Arg Met Leu Leu Cys Asp Ile Lys Pro Gln Ile 
            100                 105                 110         


Lys Thr Ser Asp Pro Ser Thr Leu Gln Val Glu Met Phe Cys Gln Arg 
        115                 120                 125             


Glu Ala Glu Arg Cys Thr Gly Ala Ser Trp Gln Phe Ala Thr Asn Gly 
    130                 135                 140                 


Glu Lys Ser Leu Leu Phe Asp Ala Met Asn Met Thr Trp Thr Val Ile 
145                 150                 155                 160 


Asn His Glu Ala Ser Lys Ile Lys Glu Thr Trp Lys Lys Asp Arg Gly 
                165                 170                 175     


Leu Glu Lys Tyr Phe Arg Lys Leu Ser Lys Gly Asp Cys Asp His Trp 
            180                 185                 190         


Leu Arg Glu Phe Leu Gly His Trp Glu Ala Met Pro Glu Pro Thr Val 
        195                 200                 205             


Ser Pro Val Asn Ala Ser Asp Ile His Trp Ser Ser Ser Ser Leu Pro 
    210                 215                 220                 


Asp Arg Trp Ile Ile Leu Gly Ala Phe Ile Leu Leu Val Leu Met Gly 
225                 230                 235                 240 


Ile Val Leu Ile Cys Val Trp Trp Gln Asn Gly Glu Trp Gln Ala Gly 
                245                 250                 255     


Leu Trp Pro Leu Arg Thr Ser 
            260             


<210>  5841
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  5841

Met Asp Arg Ser Thr Asn Leu Asp Ile Glu Glu Leu Lys Met Thr Arg 
1               5                   10                  15      


Glu Gln Tyr Ile Leu Ala Thr Gln Gln Asn Asn Leu Pro Arg Thr Glu 
            20                  25                  30          


Asn Ala Gln Leu Tyr Pro Val Gly Ile Tyr Gly Trp Arg Lys Arg Cys 
        35                  40                  45              


Leu Tyr Phe Phe Val Leu Leu Leu Leu Val Thr Met Ile Val Asn Leu 
    50                  55                  60                  


Ala Met Thr Ile Trp Ile Leu Lys Val Met Asn Phe Thr Val Asp Gly 
65                  70                  75                  80  


Met Gly Asn Leu Arg Val Thr Lys Lys Gly Ile Arg Leu Glu Gly Ile 
                85                  90                  95      


Ser Glu Phe Leu Leu Pro Leu Tyr Val Lys Glu Ile His Ser Arg Lys 
            100                 105                 110         


Asp Ser Pro Leu Val Leu Gln Ser Asp Arg Asn Val Thr Val Asn Ala 
        115                 120                 125             


Arg Asn His Met Gly Gln Leu Thr Gly Gln Leu Thr Ile Gly Ala Asp 
    130                 135                 140                 


Ala Val Glu Ala Gln Cys Lys Arg Phe Glu Val Arg Ala Ser Glu Asp 
145                 150                 155                 160 


Gly Arg Val Leu Phe Ser Ala Asp Glu Asp Glu Ile Thr Ile Gly Ala 
                165                 170                 175     


Glu Lys Leu Lys Val Thr Gly Thr Glu Gly Ala Val Phe Gly His Ser 
            180                 185                 190         


Val Glu Thr Pro His Ile Arg Ala Glu Pro Ser Gln Asp Leu Arg Leu 
        195                 200                 205             


Glu Ser Pro Thr Arg Ser Leu Ile Met Glu Ala Pro Arg Gly Val Gln 
    210                 215                 220                 


Val Ser Ala Ala Ala Gly Asp Phe Lys Ala Thr Cys Arg Lys Glu Leu 
225                 230                 235                 240 


His Leu Gln Ser Thr Glu Gly Glu Ile Phe Leu Asn Ala Glu Thr Ile 
                245                 250                 255     


Lys Leu Gly Asn Leu Pro Thr Gly Ser Phe Ser Ser Ser Ser Pro Ser 
            260                 265                 270         


Ser Ser Ser Ser Arg Gln Thr Val Tyr Glu Leu Cys Val Cys Pro Asn 
        275                 280                 285             


Gly Lys Leu Tyr Leu Ser Pro Ala Gly Val Gly Ser Thr Cys Gln Ser 
    290                 295                 300                 


Ser Ser Asn Ile Cys Leu Trp Ser 
305                 310         


<210>  5842
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  5842

Met Leu Gly Cys Gly Ile Pro Ala Leu Gly Leu Leu Leu Leu Leu Gln 
1               5                   10                  15      


Gly Ser Ala Asp Gly Asn Gly Ile Gln Gly Phe Phe Tyr Pro Trp Ser 
            20                  25                  30          


Cys Glu Gly Asp Ile Trp Asp Arg Glu Ser Cys Gly Gly Gln Ala Ala 
        35                  40                  45              


Ile Asp Ser Pro Asn Leu Cys Leu Arg Leu Arg Cys Cys Tyr Arg Asn 
    50                  55                  60                  


Gly Val Cys Tyr His Gln Arg Pro Asp Glu Asn Val Arg Arg Lys His 
65                  70                  75                  80  


Met Trp Ala Leu Val Trp Thr Cys Ser Gly Leu Leu Leu Leu Ser Cys 
                85                  90                  95      


Ser Ile Cys Leu Phe Trp Trp Ala Lys Arg Arg Asp Val Leu His Met 
            100                 105                 110         


Pro Gly Phe Leu Ala Gly Pro Cys Asp Met Ser Lys Ser Val Ser Leu 
        115                 120                 125             


Leu Ser Lys His Arg Gly Thr Lys Lys Thr Pro Ser Thr Gly Ser Val 
    130                 135                 140                 


Pro Val Ala Leu Ser Lys Glu Ser Arg Asp Val Glu Gly Gly Thr Glu 
145                 150                 155                 160 


Gly Glu Gly Thr Glu Glu Gly Glu Glu Thr Glu Gly Glu Glu Glu Glu 
                165                 170                 175     


Asp 
    


<210>  5843
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  5843

Met His Thr Thr Glu Ser Lys Asn Glu His Leu Glu Asp Glu Asn Phe 
1               5                   10                  15      


Gln Thr Ser Thr Thr Pro Gln Ser Leu Ile Asp Pro Asn Asn Thr Ala 
            20                  25                  30          


His Glu Glu Thr Lys Thr Val Leu Ser Asp Thr Glu Glu Ile Lys Pro 
        35                  40                  45              


Gln Thr Lys Lys Glu Thr Tyr Ile Ser Cys Pro Leu Arg Gly Val Leu 
    50                  55                  60                  


Asn Val Ile Ile Thr Asn Gly Val Ile Leu Phe Val Ile Trp Cys Met 
65                  70                  75                  80  


Thr Trp Ser Ile Leu Gly Ser Glu Ala Leu Pro Gly Gly Asn Leu Phe 
                85                  90                  95      


Gly Leu Phe Ile Ile Phe Tyr Ser Ala Ile Ile Gly Gly Lys Ile Leu 
            100                 105                 110         


Gln Leu Ile Arg Ile Pro Leu Val Pro Pro Leu Pro Pro Leu Leu Gly 
        115                 120                 125             


Met Leu Leu Ala Gly Phe Thr Ile Arg Asn Val Pro Phe Ile Asn Glu 
    130                 135                 140                 


His Val His Val Pro Asn Thr Trp Ser Ser Ile Leu Arg Ser Ile Ala 
145                 150                 155                 160 


Leu Thr Ile Ile Leu Ile Arg Ala Gly Leu Gly Leu Asp Pro Gln Ala 
                165                 170                 175     


Leu Arg His Leu Lys Val Val Cys Phe Arg Leu Ala Val Gly Pro Cys 
            180                 185                 190         


Leu Met Glu Ala Ser Ala Ala Ala Val Phe Ser His Phe Ile Met Lys 
        195                 200                 205             


Phe Pro Trp Gln Trp Ala Phe Leu Leu Gly Phe Val Leu Gly Ala Val 
    210                 215                 220                 


Ser Pro Ala Val Val Val Pro Tyr Met Met Val Leu Gln Glu Asn Gly 
225                 230                 235                 240 


Tyr Gly Val Glu Glu Gly Ile Pro Thr Leu Leu Met Ala Ala Ser Ser 
                245                 250                 255     


Met Asp Asp Ile Leu Ala Ile Thr Gly Phe Asn Thr Cys Leu Ser Ile 
            260                 265                 270         


Val Phe Ser Ser Gly Gly Ile Leu Asn Asn Ala Ile Ala Ser Ile Arg 
        275                 280                 285             


Asn Val Cys Ile Ser Leu Leu Ala Gly Ile Val Leu Gly Phe Phe Val 
    290                 295                 300                 


Arg Tyr Phe Pro Ser Glu Asp Gln Lys Lys Leu Thr Leu Lys Arg Gly 
305                 310                 315                 320 


Phe Leu Val Leu Thr Met Cys Val Ser Ala Val Leu Gly Ser Gln Arg 
                325                 330                 335     


Ile Gly Leu His Gly Ser Gly Gly Leu Cys Thr Leu Val Leu Ser Phe 
            340                 345                 350         


Ile Ala Gly Thr Lys Trp Ser Gln Glu Lys Met Lys Val Gln Lys Ile 
        355                 360                 365             


Ile Thr Thr Val Trp Asp Ile Phe Gln Pro Leu Leu Phe Gly Leu Val 
    370                 375                 380                 


Gly Ala Glu Val Ser Val Ser Ser Leu Glu Ser Asn Ile Val Gly Ile 
385                 390                 395                 400 


Ser Val Ala Thr Leu Ser Leu Ala Leu Cys Val Arg Ile Leu Thr Thr 
                405                 410                 415     


Tyr Leu Leu Met Cys Phe Ala Gly Phe Ser Phe Lys Glu Lys Ile Phe 
            420                 425                 430         


Ile Ala Leu Ala Trp Met Pro Lys Ala Thr Val Gln Ala Val Leu Gly 
        435                 440                 445             


Pro Leu Ala Leu Glu Thr Ala Arg Val Ser Ala Pro His Leu Glu Pro 
    450                 455                 460                 


Tyr Ala Lys Asp Val Met Thr Val Ala Phe Leu Ala Ile Leu Ile Thr 
465                 470                 475                 480 


Ala Pro Asn Gly Ala Leu Leu Met Gly Ile Leu Gly Pro Lys Met Leu 
                485                 490                 495     


Thr Arg His Tyr Asp Pro Ser Lys Ile Lys Leu Gln Leu Ser Thr Leu 
            500                 505                 510         


Glu His His 
        515 


<210>  5844
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  5844

Met His Leu Leu Lys Val Gly Thr Trp Arg Asn Asn Thr Ala Ser Ser 
1               5                   10                  15      


Trp Leu Met Lys Phe Ser Val Leu Trp Leu Val Ser Gln Asn Cys Cys 
            20                  25                  30          


Arg Ala Ser Val Val Trp Met Ala Tyr Met Asn Ile Ser Phe His Val 
        35                  40                  45              


Gly Asn His Val Leu Ser Glu Leu Gly Glu Thr Gly Val Phe Gly Arg 
    50                  55                  60                  


Ser Ser Thr Leu Lys Arg Val Ala Gly Val Ile Val Pro Pro Glu Gly 
65                  70                  75                  80  


Lys Ile Gln Asn Ala Cys Asn Pro Asn Thr Ile Phe Ser Arg Ser Lys 
                85                  90                  95      


Tyr Ser Glu Thr Trp Leu Ala Leu Ile Glu Arg Gly Gly Cys Thr Phe 
            100                 105                 110         


Thr Gln Lys Ile Lys Val Ala Thr Glu Lys Gly Ala Ser Gly Val Ile 
        115                 120                 125             


Ile Tyr Asn Val Pro Gly Thr Gly Asn Gln Val Phe Pro Met Phe His 
    130                 135                 140                 


Gln Ala Phe Glu Asp Val Val Val Val Met Ile Gly Asn Leu Lys Gly 
145                 150                 155                 160 


Thr Glu Ile Phe His Leu Ile Lys Lys Gly Val Leu Ile Thr Ala Val 
                165                 170                 175     


Val Glu Val Gly Arg Lys His Ile Ile Trp Met Asn His Tyr Leu Val 
            180                 185                 190         


Ser Phe Val Ile Val Thr Thr Ala Thr Leu Ala Tyr Phe Ile Phe Tyr 
        195                 200                 205             


His Ile His Arg Leu Cys Leu Ala Arg Ile Gln Asn Arg Arg Trp Gln 
    210                 215                 220                 


Arg Leu Thr Thr Asp Leu Gln Asn Thr Phe Gly Gln Leu Gln Leu Arg 
225                 230                 235                 240 


Val Val Lys Glu Gly Asp Glu Glu Ile Asn Pro Asn Gly Asp Ser Cys 
                245                 250                 255     


Val Ile Cys Phe Glu Arg Tyr Lys Pro Asn Asp Ile Val Arg Ile Leu 
            260                 265                 270         


Thr Cys Lys His Phe Phe His Lys Asn Cys Ile Asp Pro Trp Ile Leu 
        275                 280                 285             


Pro His Gly Thr Cys Pro Ile Cys Lys Cys Asp Ile Leu Lys Val Leu 
    290                 295                 300                 


Gly Ile Gln Val Val Val Glu Asn Gly Thr Glu Pro Leu Gln Val Leu 
305                 310                 315                 320 


Met Ser Asn Glu Leu Pro Glu Thr Leu Ser Pro Ser Glu Glu Glu Thr 
                325                 330                 335     


Asn Asn Glu Val Ser Pro Ala Gly Thr Ser Asp Lys Val Ile His Val 
            340                 345                 350         


Glu Glu Asn Pro Thr Ser Gln Asn Asn Asp Ile Gln Pro His Ser Val 
        355                 360                 365             


Val Glu Asp Val His Pro Ser Pro 
    370                 375     


<210>  5845
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  5845

Met Leu Gln Gly His Ser Ser Val Phe Gln Ala Leu Leu Gly Thr Phe 
1               5                   10                  15      


Phe Thr Trp Gly Met Thr Ala Ala Gly Ala Ala Leu Val Phe Val Phe 
            20                  25                  30          


Ser Ser Gly Gln Arg Arg Ile Leu Asp Gly Ser Leu Gly Phe Ala Ala 
        35                  40                  45              


Gly Val Met Leu Ala Ala Ser Tyr Trp Ser Leu Leu Ala Pro Ala Val 
    50                  55                  60                  


Glu Met Ala Thr Ser Ser Gly Gly Phe Gly Ala Phe Ala Phe Phe Pro 
65                  70                  75                  80  


Val Ala Val Gly Phe Thr Leu Gly Ala Ala Phe Val Tyr Leu Ala Asp 
                85                  90                  95      


Leu Leu Met Pro His Leu Gly Ala Ala Glu Asp Pro Gln Thr Thr Leu 
            100                 105                 110         


Ala Leu Asn Phe Gly Ser Thr Leu Met Lys Lys Lys Ser Asp Pro Glu 
        115                 120                 125             


Gly Pro Ala Leu Leu Phe Pro Glu Ser Glu Leu Ser Ile Arg Ile Asp 
    130                 135                 140                 


Lys Ser Glu Asn Gly Glu Ala Tyr Gln Arg Lys Lys Ala Ala Ala Thr 
145                 150                 155                 160 


Gly Leu Pro Glu Gly Pro Ala Val Pro Val Pro Ser Arg Gly Asn Leu 
                165                 170                 175     


Ala Gln Pro Gly Gly Ser Ser Trp Arg Arg Ile Ala Leu Leu Ile Leu 
            180                 185                 190         


Ala Ile Thr Ile His Asn Val Pro Glu Gly Leu Ala Val Gly Val Gly 
        195                 200                 205             


Phe Gly Ala Ile Glu Lys Thr Ala Ser Ala Thr Phe Glu Ser Ala Arg 
    210                 215                 220                 


Asn Leu Ala Ile Gly Ile Gly Ile Gln Asn Phe Pro Glu Gly Leu Ala 
225                 230                 235                 240 


Val Ser Leu Pro Leu Arg Gly Ala Gly Phe Ser Thr Trp Arg Ala Phe 
                245                 250                 255     


Trp Tyr Gly Gln Leu Ser Gly Met Val Glu Pro Leu Ala Gly Val Phe 
            260                 265                 270         


Gly Ala Phe Ala Val Val Leu Ala Glu Pro Ile Leu Pro Tyr Ala Leu 
        275                 280                 285             


Ala Phe Ala Ala Gly Ala Met Val Tyr Val Val Met Asp Asp Ile Ile 
    290                 295                 300                 


Pro Glu Ala Gln Ile Ser Gly Asn Gly Lys Leu Ala Ser Trp Ala Ser 
305                 310                 315                 320 


Ile Leu Gly Phe Val Val Met Met Ser Leu Asp Val Gly Leu Gly 
                325                 330                 335 


<210>  5846
<211>  672
<212>  PRT
<213>  Homo sapiens

<400>  5846

Met Pro Gly Met Val Leu Phe Gly Arg Arg Trp Ala Ile Ala Ser Asp 
1               5                   10                  15      


Asp Leu Val Phe Pro Gly Phe Phe Glu Leu Val Val Arg Val Leu Trp 
            20                  25                  30          


Trp Ile Gly Ile Leu Thr Leu Tyr Leu Met His Arg Gly Lys Leu Asp 
        35                  40                  45              


Cys Ala Gly Gly Ala Leu Leu Ser Ser Tyr Leu Ile Val Leu Met Ile 
    50                  55                  60                  


Leu Leu Ala Val Val Ile Cys Thr Val Ser Ala Ile Met Cys Val Ser 
65                  70                  75                  80  


Met Arg Gly Thr Ile Cys Asn Pro Gly Pro Arg Lys Ser Met Ser Lys 
                85                  90                  95      


Leu Leu Tyr Ile Arg Leu Ala Leu Phe Phe Pro Glu Met Val Trp Ala 
            100                 105                 110         


Ser Leu Gly Ala Ala Trp Val Ala Asp Gly Val Gln Cys Asp Arg Thr 
        115                 120                 125             


Val Val Asn Gly Ile Ile Ala Thr Val Val Val Ser Trp Ile Ile Ile 
    130                 135                 140                 


Ala Ala Thr Val Val Ser Ile Ile Ile Val Phe Asp Pro Leu Gly Gly 
145                 150                 155                 160 


Lys Met Ala Pro Tyr Ser Ser Ala Gly Pro Ser His Leu Asp Ser His 
                165                 170                 175     


Asp Ser Ser Gln Leu Leu Asn Gly Leu Lys Thr Ala Ala Thr Ser Val 
            180                 185                 190         


Trp Glu Thr Arg Ile Lys Leu Leu Cys Cys Cys Ile Gly Lys Asp Asp 
        195                 200                 205             


His Thr Arg Val Ala Phe Ser Ser Thr Ala Glu Leu Phe Ser Thr Tyr 
    210                 215                 220                 


Phe Ser Asp Thr Asp Leu Val Pro Ser Asp Ile Ala Ala Gly Leu Ala 
225                 230                 235                 240 


Leu Leu His Gln Gln Gln Asp Asn Ile Arg Asn Asn Gln Glu Pro Ala 
                245                 250                 255     


Gln Val Val Cys His Ala Pro Gly Ser Ser Gln Glu Ala Asp Leu Asp 
            260                 265                 270         


Ala Glu Leu Glu Asn Cys His His Tyr Met Gln Phe Ala Ala Ala Ala 
        275                 280                 285             


Tyr Gly Trp Pro Leu Tyr Ile Tyr Arg Asn Pro Leu Thr Gly Leu Cys 
    290                 295                 300                 


Arg Ile Gly Gly Asp Cys Cys Arg Ser Arg Thr Thr Asp Tyr Asp Leu 
305                 310                 315                 320 


Val Gly Gly Asp Gln Leu Asn Cys His Phe Gly Ser Ile Leu His Thr 
                325                 330                 335     


Thr Gly Leu Gln Tyr Arg Asp Phe Ile His Val Ser Phe His Asp Lys 
            340                 345                 350         


Val Tyr Glu Leu Pro Phe Leu Val Ala Leu Asp His Arg Lys Glu Ser 
        355                 360                 365             


Val Val Val Ala Val Arg Gly Thr Met Ser Leu Gln Asp Val Leu Thr 
    370                 375                 380                 


Asp Leu Ser Ala Glu Ser Glu Val Leu Asp Val Glu Cys Glu Val Gln 
385                 390                 395                 400 


Asp Arg Leu Ala His Lys Gly Ile Ser Gln Ala Ala Arg Tyr Val Tyr 
                405                 410                 415     


Gln Arg Leu Ile Asn Asp Gly Ile Leu Ser Gln Ala Phe Ser Ile Ala 
            420                 425                 430         


Pro Glu Tyr Arg Leu Val Ile Val Gly His Ser Leu Gly Gly Gly Ala 
        435                 440                 445             


Ala Ala Leu Leu Ala Thr Met Leu Arg Ala Ala Tyr Pro Gln Val Arg 
    450                 455                 460                 


Cys Tyr Ala Phe Ser Pro Pro Arg Gly Leu Trp Ser Lys Ala Leu Gln 
465                 470                 475                 480 


Glu Tyr Ser Gln Ser Phe Ile Val Ser Leu Val Leu Gly Lys Asp Val 
                485                 490                 495     


Ile Pro Arg Leu Ser Val Thr Asn Leu Glu Asp Leu Lys Arg Arg Ile 
            500                 505                 510         


Leu Arg Val Val Ala His Cys Asn Lys Pro Lys Tyr Lys Ile Leu Leu 
        515                 520                 525             


His Gly Leu Trp Tyr Glu Leu Phe Gly Gly Asn Pro Asn Asn Leu Pro 
    530                 535                 540                 


Thr Glu Leu Asp Gly Gly Asp Gln Glu Val Leu Thr Gln Pro Leu Leu 
545                 550                 555                 560 


Gly Glu Gln Ser Leu Leu Thr Arg Trp Ser Pro Ala Tyr Ser Phe Ser 
                565                 570                 575     


Ser Asp Ser Pro Leu Asp Ser Ser Pro Lys Tyr Pro Pro Leu Tyr Pro 
            580                 585                 590         


Pro Gly Arg Ile Ile His Leu Gln Glu Glu Gly Ala Ser Gly Arg Phe 
        595                 600                 605             


Gly Cys Cys Ser Ala Ala His Tyr Ser Ala Lys Trp Ser His Glu Ala 
    610                 615                 620                 


Glu Phe Ser Lys Ile Leu Ile Gly Pro Lys Met Leu Thr Asp His Met 
625                 630                 635                 640 


Pro Asp Ile Leu Met Arg Ala Leu Asp Ser Val Val Ser Asp Arg Ala 
                645                 650                 655     


Ala Cys Val Ser Cys Pro Ala Gln Gly Val Ser Ser Val Asp Val Ala 
            660                 665                 670         


<210>  5847
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  5847

Met Thr Gln Glu Pro Phe Arg Glu Glu Leu Ala Tyr Asp Arg Met Pro 
1               5                   10                  15      


Thr Leu Glu Arg Gly Arg Gln Asp Pro Ala Ser Tyr Ala Pro Asp Ala 
            20                  25                  30          


Lys Pro Ser Asp Leu Gln Leu Ser Lys Arg Leu Pro Pro Cys Phe Ser 
        35                  40                  45              


His Lys Thr Trp Val Phe Ser Val Leu Met Gly Ser Cys Leu Leu Val 
    50                  55                  60                  


Thr Ser Gly Phe Ser Leu Tyr Leu Gly Asn Val Phe Pro Ala Glu Met 
65                  70                  75                  80  


Asp Tyr Leu Arg Cys Ala Ala Gly Ser Cys Ile Pro Ser Ala Ile Val 
                85                  90                  95      


Ser Phe Thr Val Ser Arg Arg Asn Ala Asn Val Ile Pro Asn Phe Gln 
            100                 105                 110         


Ile Leu Phe Val Ser Thr Phe Ala Val Thr Thr Thr Cys Leu Ile Trp 
        115                 120                 125             


Phe Gly Cys Lys Leu Val Leu Asn Pro Ser Ala Ile Asn Ile Asn Phe 
    130                 135                 140                 


Asn Leu Ile Leu Leu Leu Leu Leu Glu Leu Leu Met Ala Ala Thr Val 
145                 150                 155                 160 


Ile Ile Ala Ala Arg Ser Ser Glu Glu Asp Cys Lys Lys Lys Lys Gly 
                165                 170                 175     


Ser Met Ser Asp Ser Ala Asn Ile Leu Asp Glu Val Pro Phe Pro Ala 
            180                 185                 190         


Arg Val Leu Lys Ser Tyr Ser Val Val Glu Val Ile Ala Gly Ile Ser 
        195                 200                 205             


Ala Val Leu Gly Gly Ile Ile Ala Leu Asn Val Asp Asp Ser Val Ser 
    210                 215                 220                 


Gly Pro His Leu Ser Val Thr Phe Phe Trp Ile Leu Val Ala Cys Phe 
225                 230                 235                 240 


Pro Ser Ala Ile Ala Ser His Val Ala Ala Glu Cys Pro Ser Lys Cys 
                245                 250                 255     


Leu Val Glu Val Leu Ile Ala Ile Ser Ser Leu Thr Ser Pro Leu Leu 
            260                 265                 270         


Phe Thr Ala Ser Gly Tyr Leu Ser Phe Ser Ile Met Arg Ile Val Glu 
        275                 280                 285             


Met Phe Lys Asp Tyr Pro Pro Ala Ile Lys Pro Ser Tyr Asp Val Leu 
    290                 295                 300                 


Leu Leu Leu Leu Leu Leu Val Leu Leu Leu Gln Ala Gly Leu Asn Thr 
305                 310                 315                 320 


Gly Thr Ala Ile Gln Cys Val Arg Phe Lys Val Ser Ala Arg Leu Gln 
                325                 330                 335     


Gly Ala Ser Trp Asp Thr Gln Asn Gly Pro Gln Glu Arg Leu Ala Gly 
            340                 345                 350         


Glu Val Ala Arg Ser Pro Leu Lys Glu Phe Asp Lys Glu Lys Ala Trp 
        355                 360                 365             


Arg Ala Val Val Val Gln Met Ala Gln 
    370                 375         


<210>  5848
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  5848

Met Ile Glu Asp Thr Met Thr Leu Leu Ser Leu Leu Gly Arg Ile Met 
1               5                   10                  15      


Arg Tyr Phe Leu Leu Arg Pro Glu Thr Leu Phe Leu Leu Cys Ile Ser 
            20                  25                  30          


Leu Ala Leu Trp Ser Tyr Phe Phe His Thr Asp Glu Val Lys Thr Ile 
        35                  40                  45              


Val Lys Ser Ser Arg Asp Ala Val Lys Met Val Lys Gly Lys Val Ala 
    50                  55                  60                  


Glu Ile Met Gln Asn Asp Arg Leu Gly Gly Leu Asp Val Leu Glu Ala 
65                  70                  75                  80  


Glu Phe Ser Lys Thr Trp Glu Phe Lys Asn His Asn Val Ala Val Tyr 
                85                  90                  95      


Ser Ile Gln Gly Arg Arg Asp His Met Glu Asp Arg Phe Glu Val Leu 
            100                 105                 110         


Thr Asp Leu Ala Asn Lys Thr His Pro Ser Ile Phe Gly Ile Phe Asp 
        115                 120                 125             


Gly His Gly Gly Glu Thr Ala Ala Glu Tyr Val Lys Ser Arg Leu Pro 
    130                 135                 140                 


Glu Ala Leu Lys Gln His Leu Gln Asp Tyr Glu Lys Asp Lys Glu Asn 
145                 150                 155                 160 


Ser Val Leu Ser Tyr Gln Thr Ile Leu Glu Gln Gln Ile Leu Ser Ile 
                165                 170                 175     


Asp Arg Glu Met Leu Glu Lys Leu Thr Val Ser Tyr Asp Glu Ala Gly 
            180                 185                 190         


Thr Thr Cys Leu Ile Ala Leu Leu Ser Asp Lys Asp Leu Thr Val Ala 
        195                 200                 205             


Asn Val Gly Asp Ser Arg Gly Val Leu Cys Asp Lys Asp Gly Asn Ala 
    210                 215                 220                 


Ile Pro Leu Ser His Asp His Lys Pro Tyr Gln Leu Lys Glu Arg Lys 
225                 230                 235                 240 


Arg Ile Lys Arg Ala Gly Gly Phe Ile Ser Phe Asn Gly Ser Trp Arg 
                245                 250                 255     


Val Gln Gly Ile Leu Ala Met Ser Arg Ser Leu Gly Asp Tyr Pro Leu 
            260                 265                 270         


Lys Asn Leu Asn Val Val Ile Pro Asp Pro Asp Ile Leu Thr Phe Asp 
        275                 280                 285             


Leu Asp Lys Leu Gln Pro Glu Phe Met Ile Leu Ala Ser Asp Gly Leu 
    290                 295                 300                 


Trp Asp Ala Phe Ser Asn Glu Glu Ala Val Arg Phe Ile Lys Glu Arg 
305                 310                 315                 320 


Leu Asp Glu Pro His Phe Gly Ala Lys Ser Ile Val Leu Gln Ser Phe 
                325                 330                 335     


Tyr Arg Gly Cys Pro Asp Asn Ile Thr Val Met Val Val Lys Phe Arg 
            340                 345                 350         


Asn Ser Ser Lys Thr Glu Glu Gln 
        355                 360 


<210>  5849
<211>  1077
<212>  PRT
<213>  Homo sapiens

<400>  5849

Met Ala Arg Leu Phe Ser Pro Arg Pro Pro Pro Ser Glu Asp Leu Phe 
1               5                   10                  15      


Tyr Glu Thr Tyr Tyr Ser Leu Ser Gln Gln Tyr Pro Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Gly Ile Val Leu Cys Ala Leu Ala Ala Leu Leu Ala Val Ala 
        35                  40                  45              


Trp Ala Ser Gly Arg Glu Leu Thr Ser Asp Pro Ser Phe Leu Thr Thr 
    50                  55                  60                  


Val Leu Cys Ala Leu Gly Gly Phe Ser Leu Leu Leu Gly Leu Ala Ser 
65                  70                  75                  80  


Arg Glu Gln Arg Leu Gln Arg Trp Thr Arg Pro Leu Ser Gly Leu Val 
                85                  90                  95      


Trp Val Ala Leu Leu Ala Leu Gly His Ala Phe Leu Phe Thr Gly Gly 
            100                 105                 110         


Val Val Ser Ala Trp Asp Gln Val Ser Tyr Phe Leu Phe Val Ile Phe 
        115                 120                 125             


Thr Ala Tyr Ala Met Leu Pro Leu Gly Met Arg Asp Ala Ala Val Ala 
    130                 135                 140                 


Gly Leu Ala Ser Ser Leu Ser His Leu Leu Val Leu Gly Leu Tyr Leu 
145                 150                 155                 160 


Gly Pro Gln Pro Asp Ser Arg Pro Ala Leu Leu Pro Gln Leu Ala Ala 
                165                 170                 175     


Asn Ala Val Leu Phe Leu Cys Gly Asn Val Ala Gly Val Tyr His Lys 
            180                 185                 190         


Ala Leu Met Glu Arg Ala Leu Arg Ala Thr Phe Arg Glu Ala Leu Ser 
        195                 200                 205             


Ser Leu His Ser Arg Arg Arg Leu Asp Thr Glu Lys Lys His Gln Glu 
    210                 215                 220                 


His Leu Leu Leu Ser Ile Leu Pro Ala Tyr Leu Ala Arg Glu Met Lys 
225                 230                 235                 240 


Ala Glu Ile Met Ala Arg Leu Gln Ala Gly Gln Gly Ser Arg Pro Glu 
                245                 250                 255     


Ser Thr Asn Asn Phe His Ser Leu Tyr Val Lys Arg His Gln Gly Val 
            260                 265                 270         


Ser Val Leu Tyr Ala Asp Ile Val Gly Phe Thr Arg Leu Ala Ser Glu 
        275                 280                 285             


Cys Ser Pro Lys Glu Leu Val Leu Met Leu Asn Glu Leu Phe Gly Lys 
    290                 295                 300                 


Phe Asp Gln Ile Ala Lys Glu His Glu Cys Met Arg Ile Lys Ile Leu 
305                 310                 315                 320 


Gly Asp Cys Tyr Tyr Cys Val Ser Gly Leu Pro Leu Ser Leu Pro Asp 
                325                 330                 335     


His Ala Ile Asn Cys Val Arg Met Gly Leu Asp Met Cys Arg Ala Ile 
            340                 345                 350         


Arg Lys Leu Arg Ala Ala Thr Gly Val Asp Ile Asn Met Arg Val Gly 
        355                 360                 365             


Val His Ser Gly Ser Val Leu Cys Gly Val Ile Gly Leu Gln Lys Trp 
    370                 375                 380                 


Gln Tyr Asp Val Trp Ser His Asp Val Thr Leu Ala Asn His Met Glu 
385                 390                 395                 400 


Ala Gly Gly Val Pro Gly Arg Val His Ile Thr Gly Ala Thr Leu Ala 
                405                 410                 415     


Leu Leu Ala Gly Ala Tyr Ala Val Glu Asp Ala Gly Met Glu His Arg 
            420                 425                 430         


Asp Pro Tyr Leu Arg Glu Leu Gly Glu Pro Thr Tyr Leu Val Ile Asp 
        435                 440                 445             


Pro Arg Ala Glu Glu Glu Asp Glu Lys Gly Thr Ala Gly Gly Leu Leu 
    450                 455                 460                 


Ser Ser Leu Glu Gly Leu Lys Met Arg Pro Ser Leu Leu Met Thr Arg 
465                 470                 475                 480 


Tyr Leu Glu Ser Trp Gly Ala Ala Lys Pro Phe Ala His Leu Ser His 
                485                 490                 495     


Gly Asp Ser Pro Val Ser Thr Ser Thr Pro Leu Pro Glu Lys Thr Leu 
            500                 505                 510         


Ala Ser Phe Ser Thr Gln Trp Ser Leu Asp Arg Ser Arg Thr Pro Arg 
        515                 520                 525             


Gly Leu Asp Asp Glu Leu Asp Thr Gly Asp Ala Lys Phe Phe Gln Val 
    530                 535                 540                 


Ile Glu Gln Leu Asn Ser Gln Lys Gln Trp Lys Gln Ser Lys Asp Phe 
545                 550                 555                 560 


Asn Pro Leu Thr Leu Tyr Phe Arg Glu Lys Glu Met Glu Lys Glu Tyr 
                565                 570                 575     


Arg Leu Ser Ala Ile Pro Ala Phe Lys Tyr Tyr Glu Ala Cys Thr Phe 
            580                 585                 590         


Leu Val Phe Leu Ser Asn Phe Ile Ile Gln Met Leu Val Thr Asn Arg 
        595                 600                 605             


Pro Pro Ala Leu Ala Ile Thr Tyr Ser Ile Thr Phe Leu Leu Phe Leu 
    610                 615                 620                 


Leu Ile Leu Phe Val Cys Phe Ser Glu Asp Leu Met Arg Cys Val Leu 
625                 630                 635                 640 


Lys Gly Pro Lys Met Leu His Trp Leu Pro Ala Leu Ser Gly Leu Val 
                645                 650                 655     


Ala Thr Arg Pro Gly Leu Arg Ile Ala Leu Gly Thr Ala Thr Ile Leu 
            660                 665                 670         


Leu Val Phe Ala Met Ala Ile Thr Ser Leu Phe Phe Phe Pro Thr Ser 
        675                 680                 685             


Ser Asp Cys Pro Phe Gln Ala Pro Asn Val Ser Ser Met Ile Ser Asn 
    690                 695                 700                 


Leu Ser Trp Glu Leu Pro Gly Ser Leu Pro Leu Ile Ser Val Pro Tyr 
705                 710                 715                 720 


Ser Met His Cys Cys Thr Leu Gly Phe Leu Ser Cys Ser Leu Phe Leu 
                725                 730                 735     


His Met Ser Phe Glu Leu Lys Leu Leu Leu Leu Leu Leu Trp Leu Ala 
            740                 745                 750         


Ala Ser Cys Ser Leu Phe Leu His Ser His Ala Trp Leu Ser Glu Cys 
        755                 760                 765             


Leu Ile Val Arg Leu Tyr Leu Gly Pro Leu Asp Ser Arg Pro Gly Val 
    770                 775                 780                 


Leu Lys Glu Pro Lys Leu Met Gly Ala Ile Ser Phe Phe Ile Phe Phe 
785                 790                 795                 800 


Phe Thr Leu Leu Val Leu Ala Arg Gln Asn Glu Tyr Tyr Cys Arg Leu 
                805                 810                 815     


Asp Phe Leu Trp Lys Lys Lys Leu Arg Gln Glu Arg Glu Glu Thr Glu 
            820                 825                 830         


Thr Met Glu Asn Leu Thr Arg Leu Leu Leu Glu Asn Val Leu Pro Ala 
        835                 840                 845             


His Val Ala Pro Gln Phe Ile Gly Gln Asn Arg Arg Asn Glu Asp Leu 
    850                 855                 860                 


Tyr His Gln Ser Tyr Glu Cys Val Cys Val Leu Phe Ala Ser Val Pro 
865                 870                 875                 880 


Asp Phe Lys Glu Phe Tyr Ser Glu Ser Asn Ile Asn His Glu Gly Leu 
                885                 890                 895     


Glu Cys Leu Arg Leu Leu Asn Glu Ile Ile Ala Asp Phe Asp Glu Leu 
            900                 905                 910         


Leu Ser Lys Pro Lys Phe Ser Gly Val Glu Lys Ile Lys Thr Ile Gly 
        915                 920                 925             


Ser Thr Tyr Met Ala Ala Thr Gly Leu Asn Ala Thr Ser Gly Gln Asp 
    930                 935                 940                 


Ala Gln Gln Asp Ala Glu Arg Ser Cys Ser His Leu Gly Thr Met Val 
945                 950                 955                 960 


Glu Phe Ala Val Ala Leu Gly Ser Lys Leu Asp Val Ile Asn Lys His 
                965                 970                 975     


Ser Phe Asn Asn Phe Arg Leu Arg Val Gly Leu Asn His Gly Pro Val 
            980                 985                 990         


Val Ala Gly Val Ile Gly Ala Gln  Lys Pro Gln Tyr Asp  Ile Trp Gly 
        995                 1000                 1005             


Asn Thr  Val Asn Val Ala Ser  Arg Met Glu Ser Thr  Gly Val Leu 
    1010                 1015                 1020             


Gly Lys  Ile Gln Val Thr Glu  Glu Thr Ala Trp Ala  Leu Gln Ser 
    1025                 1030                 1035             


Leu Gly  Tyr Thr Cys Tyr Ser  Arg Gly Val Ile Lys  Val Lys Gly 
    1040                 1045                 1050             


Lys Gly  Gln Leu Cys Thr Tyr  Phe Leu Asn Thr Asp  Leu Thr Arg 
    1055                 1060                 1065             


Thr Gly  Pro Pro Ser Ala Thr  Leu Gly 
    1070                 1075         


<210>  5850
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  5850

Met Thr Ser Gln Pro Ile Ser Asn Glu Thr Ile Ile Met Leu Pro Ser 
1               5                   10                  15      


Asn Val Ile Asn Phe Ser Gln Ala Glu Lys Pro Glu Pro Thr Asn Gln 
            20                  25                  30          


Gly Gln Asp Ser Leu Lys Lys Arg Leu Gln Ala Lys Val Lys Val Ile 
        35                  40                  45              


Gly Val His Ser Ser Leu Ala Gly Ser Ile Leu Ser Ala Leu Ser Ala 
    50                  55                  60                  


Leu Val Gly Phe Ile Leu Leu Ser Val Asn Pro Ala Ala Leu Asn Pro 
65                  70                  75                  80  


Ala Ser Leu Gln Cys Lys Leu Asp Glu Lys Asp Ile Pro Thr Arg Leu 
                85                  90                  95      


Leu Leu Ser Tyr Asp Tyr His Ser Pro Tyr Thr Met Asp Cys His Arg 
            100                 105                 110         


Ala Lys Ala Ser Leu Ala Gly Thr Leu Ser Leu Met Leu Val Ser Thr 
        115                 120                 125             


Val Leu Glu Phe Cys Leu Ala Val Leu Thr Ala Val Leu Gln Trp Lys 
    130                 135                 140                 


Gln Thr Val 
145         


<210>  5851
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  5851

Met Asn Val Gly Thr Ala His Ser Glu Val Asn Pro Asn Thr Arg Val 
1               5                   10                  15      


Met Asn Ser Arg Gly Ile Trp Leu Ser Tyr Val Leu Ala Ile Gly Leu 
            20                  25                  30          


Leu His Ile Val Leu Leu Ser Ile Pro Phe Val Ser Val Pro Val Val 
        35                  40                  45              


Trp Thr Leu Thr Asn Leu Ile His Asn Met Gly Met Tyr Ile Phe Leu 
    50                  55                  60                  


His Thr Val Lys Gly Thr Pro Phe Glu Thr Pro Asp Gln Gly Lys Ala 
65                  70                  75                  80  


Arg Leu Leu Thr His Trp Glu Gln Met Asp Tyr Gly Val Gln Phe Thr 
                85                  90                  95      


Ala Ser Arg Lys Phe Leu Thr Ile Thr Pro Ile Val Leu Tyr Phe Leu 
            100                 105                 110         


Thr Ser Phe Tyr Thr Lys Tyr Asp Gln Ile His Phe Val Leu Asn Thr 
        115                 120                 125             


Val Ser Leu Met Ser Val Leu Ile Pro Lys Leu Pro Gln Leu His Gly 
    130                 135                 140                 


Val Arg Ile Phe Gly Ile Asn Lys Tyr 
145                 150             


<210>  5852
<211>  773
<212>  PRT
<213>  Homo sapiens

<400>  5852

Met Phe Ser Leu Ser Ser Thr Val Gln Pro Gln Val Thr Val Pro Leu 
1               5                   10                  15      


Ser His Leu Ile Asn Ala Phe His Thr Pro Lys Asn Thr Ser Val Ser 
            20                  25                  30          


Leu Ser Gly Val Ser Val Ser Gln Asn Gln His Arg Asp Val Val Pro 
        35                  40                  45              


Glu His Glu Ala Pro Ser Ser Glu Cys Met Phe Ser Asp Phe Leu Thr 
    50                  55                  60                  


Lys Leu Asn Ile Val Ser Ile Gly Lys Gly Lys Ile Phe Glu Gly Tyr 
65                  70                  75                  80  


Arg Ser Met Phe Met Glu Pro Ala Lys Arg Met Lys Lys Ser Leu Asp 
                85                  90                  95      


Thr Thr Asp Asn Trp His Ile Arg Pro Glu Pro Phe Ser Leu Ser Ile 
            100                 105                 110         


Pro Pro Ser Leu Asn Leu Arg Asp Leu Gly Leu Ser Glu Leu Lys Ile 
        115                 120                 125             


Gly Gln Ile Asp Gln Leu Val Glu Asn Leu Leu Pro Gly Phe Cys Lys 
    130                 135                 140                 


Gly Lys Asn Ile Ser Ser His Trp His Thr Ser His Val Ser Ala Gln 
145                 150                 155                 160 


Ser Phe Phe Glu Asn Lys Tyr Gly Asn Leu Asp Ile Phe Ser Thr Leu 
                165                 170                 175     


Arg Ser Ser Cys Leu Tyr Arg His His Ser Arg Ala Leu Gln Ser Ile 
            180                 185                 190         


Cys Ser Asp Leu Gln Tyr Trp Pro Val Phe Ile Gln Ser Arg Gly Phe 
        195                 200                 205             


Lys Thr Leu Lys Ser Arg Thr Arg Arg Leu Gln Ser Thr Ser Glu Arg 
    210                 215                 220                 


Leu Ala Glu Thr Gln Asn Ile Ala Pro Ser Phe Val Lys Gly Phe Leu 
225                 230                 235                 240 


Leu Arg Asp Arg Gly Ser Asp Val Glu Ser Leu Asp Lys Leu Met Lys 
                245                 250                 255     


Thr Lys Asn Ile Pro Glu Ala His Gln Asp Ala Phe Lys Thr Gly Phe 
            260                 265                 270         


Ala Glu Gly Phe Leu Lys Ala Gln Ala Leu Thr Gln Lys Thr Asn Asp 
        275                 280                 285             


Ser Leu Arg Arg Thr Arg Leu Ile Leu Phe Val Leu Leu Leu Phe Gly 
    290                 295                 300                 


Ile Tyr Gly Leu Leu Lys Asn Pro Phe Leu Ser Val Arg Phe Arg Thr 
305                 310                 315                 320 


Thr Thr Gly Leu Asp Ser Ala Val Asp Pro Val Gln Met Lys Asn Val 
                325                 330                 335     


Thr Phe Glu His Val Lys Gly Val Glu Glu Ala Lys Gln Glu Leu Gln 
            340                 345                 350         


Glu Val Val Glu Phe Leu Lys Asn Pro Gln Lys Phe Thr Ile Leu Gly 
        355                 360                 365             


Gly Lys Leu Pro Lys Gly Ile Leu Leu Val Gly Pro Pro Gly Thr Gly 
    370                 375                 380                 


Lys Thr Leu Leu Ala Arg Ala Val Ala Gly Glu Ala Asp Val Pro Phe 
385                 390                 395                 400 


Tyr Tyr Ala Ser Gly Ser Glu Phe Asp Glu Met Phe Val Gly Val Gly 
                405                 410                 415     


Ala Ser Arg Ile Arg Asn Leu Phe Arg Glu Ala Lys Ala Asn Ala Pro 
            420                 425                 430         


Cys Val Ile Phe Ile Asp Glu Leu Asp Ser Val Gly Gly Lys Arg Ile 
        435                 440                 445             


Glu Ser Pro Met His Pro Tyr Ser Arg Gln Thr Ile Asn Gln Leu Leu 
    450                 455                 460                 


Ala Glu Met Asp Gly Phe Lys Pro Asn Glu Gly Val Ile Ile Ile Gly 
465                 470                 475                 480 


Ala Thr Asn Phe Pro Glu Ala Leu Asp Asn Ala Leu Ile Arg Pro Gly 
                485                 490                 495     


Arg Phe Asp Met Gln Val Thr Val Pro Arg Pro Asp Val Lys Gly Arg 
            500                 505                 510         


Thr Glu Ile Leu Lys Trp Tyr Leu Asn Lys Ile Lys Phe Asp Gln Ser 
        515                 520                 525             


Val Asp Pro Glu Ile Ile Ala Arg Gly Thr Val Gly Phe Ser Gly Ala 
    530                 535                 540                 


Glu Leu Glu Asn Leu Val Asn Gln Ala Ala Leu Lys Ala Ala Val Asp 
545                 550                 555                 560 


Gly Lys Glu Met Val Thr Met Lys Glu Leu Glu Phe Ser Lys Asp Lys 
                565                 570                 575     


Ile Leu Met Gly Pro Glu Arg Arg Ser Val Glu Ile Asp Asn Lys Asn 
            580                 585                 590         


Lys Thr Ile Thr Ala Tyr His Glu Ser Gly His Ala Ile Ile Ala Tyr 
        595                 600                 605             


Tyr Thr Lys Asp Ala Met Pro Ile Asn Lys Ala Thr Ile Met Pro Arg 
    610                 615                 620                 


Gly Pro Thr Leu Gly His Val Ser Leu Leu Pro Glu Asn Asp Arg Trp 
625                 630                 635                 640 


Asn Glu Thr Arg Ala Gln Leu Leu Ala Gln Met Asp Val Ser Met Gly 
                645                 650                 655     


Gly Arg Val Ala Glu Glu Leu Ile Phe Gly Thr Asp His Ile Thr Thr 
            660                 665                 670         


Gly Ala Ser Ser Asp Phe Asp Asn Ala Thr Lys Ile Ala Lys Arg Met 
        675                 680                 685             


Val Thr Lys Phe Gly Met Ser Glu Lys Leu Gly Val Met Thr Tyr Ser 
    690                 695                 700                 


Asp Thr Gly Lys Leu Ser Pro Glu Thr Gln Ser Ala Ile Glu Gln Glu 
705                 710                 715                 720 


Ile Arg Ile Leu Leu Arg Asp Ser Tyr Glu Arg Ala Lys His Ile Leu 
                725                 730                 735     


Lys Thr His Ala Lys Glu His Lys Asn Leu Ala Glu Ala Leu Leu Thr 
            740                 745                 750         


Tyr Glu Thr Leu Asp Ala Lys Glu Ile Gln Ile Val Leu Glu Gly Lys 
        755                 760                 765             


Lys Leu Glu Val Arg 
    770             


<210>  5853
<211>  988
<212>  PRT
<213>  Homo sapiens

<400>  5853

Met Pro Gly Gly Lys Arg Gly Leu Val Ala Pro Gln Asn Thr Phe Leu 
1               5                   10                  15      


Glu Asn Ile Val Arg Arg Ser Ser Glu Ser Ser Phe Leu Leu Gly Asn 
            20                  25                  30          


Ala Gln Ile Val Asp Trp Pro Val Val Tyr Ser Asn Asp Gly Phe Cys 
        35                  40                  45              


Lys Leu Ser Gly Tyr His Arg Ala Asp Val Met Gln Lys Ser Ser Thr 
    50                  55                  60                  


Cys Ser Phe Met Tyr Gly Glu Leu Thr Asp Lys Lys Thr Ile Glu Lys 
65                  70                  75                  80  


Val Arg Gln Thr Phe Asp Asn Tyr Glu Ser Asn Cys Phe Glu Val Leu 
                85                  90                  95      


Leu Tyr Lys Lys Asn Arg Thr Pro Val Trp Phe Tyr Met Gln Ile Ala 
            100                 105                 110         


Pro Ile Arg Asn Glu His Glu Lys Val Val Leu Phe Leu Cys Thr Phe 
        115                 120                 125             


Lys Asp Ile Thr Leu Phe Lys Gln Pro Ile Glu Asp Asp Ser Thr Lys 
    130                 135                 140                 


Gly Trp Thr Lys Phe Ala Arg Leu Thr Arg Ala Leu Thr Asn Ser Arg 
145                 150                 155                 160 


Ser Val Leu Gln Gln Leu Thr Pro Met Asn Lys Thr Glu Val Val His 
                165                 170                 175     


Lys His Ser Arg Leu Ala Glu Val Leu Gln Leu Gly Ser Asp Ile Leu 
            180                 185                 190         


Pro Gln Tyr Lys Gln Glu Ala Pro Lys Thr Pro Pro His Ile Ile Leu 
        195                 200                 205             


His Tyr Cys Ala Phe Lys Thr Thr Trp Asp Trp Val Ile Leu Ile Leu 
    210                 215                 220                 


Thr Phe Tyr Thr Ala Ile Met Val Pro Tyr Asn Val Ser Phe Lys Thr 
225                 230                 235                 240 


Lys Gln Asn Asn Ile Ala Trp Leu Val Leu Asp Ser Val Val Asp Val 
                245                 250                 255     


Ile Phe Leu Val Asp Ile Val Leu Asn Phe His Thr Thr Phe Val Gly 
            260                 265                 270         


Pro Gly Gly Glu Val Ile Ser Asp Pro Lys Leu Ile Arg Met Asn Tyr 
        275                 280                 285             


Leu Lys Thr Trp Phe Val Ile Asp Leu Leu Ser Cys Leu Pro Tyr Asp 
    290                 295                 300                 


Ile Ile Asn Ala Phe Glu Asn Val Asp Glu Gly Ile Ser Ser Leu Phe 
305                 310                 315                 320 


Ser Ser Leu Lys Val Val Arg Leu Leu Arg Leu Gly Arg Val Ala Arg 
                325                 330                 335     


Lys Leu Asp His Tyr Leu Glu Tyr Gly Ala Ala Val Leu Val Leu Leu 
            340                 345                 350         


Val Cys Val Phe Gly Leu Val Ala His Trp Leu Ala Cys Ile Trp Tyr 
        355                 360                 365             


Ser Ile Gly Asp Tyr Glu Val Ile Asp Glu Val Thr Asn Thr Ile Gln 
    370                 375                 380                 


Ile Asp Ser Trp Leu Tyr Gln Leu Ala Leu Ser Ile Gly Thr Pro Tyr 
385                 390                 395                 400 


Arg Tyr Asn Thr Ser Ala Gly Ile Trp Glu Gly Gly Pro Ser Lys Asp 
                405                 410                 415     


Ser Leu Tyr Val Ser Ser Leu Tyr Phe Thr Met Thr Ser Leu Thr Thr 
            420                 425                 430         


Ile Gly Phe Gly Asn Ile Ala Pro Thr Thr Asp Val Glu Lys Met Phe 
        435                 440                 445             


Ser Val Ala Met Met Met Val Gly Ser Leu Leu Tyr Ala Thr Ile Phe 
    450                 455                 460                 


Gly Asn Val Thr Thr Ile Phe Gln Gln Met Tyr Ala Asn Thr Asn Arg 
465                 470                 475                 480 


Tyr His Glu Met Leu Asn Asn Val Arg Asp Phe Leu Lys Leu Tyr Gln 
                485                 490                 495     


Val Pro Lys Gly Leu Ser Glu Arg Val Met Asp Tyr Ile Val Ser Thr 
            500                 505                 510         


Trp Ser Met Ser Lys Gly Ile Asp Thr Glu Lys Val Leu Ser Ile Cys 
        515                 520                 525             


Pro Lys Asp Met Arg Ala Asp Ile Cys Val His Leu Asn Arg Lys Val 
    530                 535                 540                 


Phe Asn Glu His Pro Ala Phe Arg Leu Ala Ser Asp Gly Cys Leu Arg 
545                 550                 555                 560 


Ala Leu Ala Val Glu Phe Gln Thr Ile His Cys Ala Pro Gly Asp Leu 
                565                 570                 575     


Ile Tyr His Ala Gly Glu Ser Val Asp Ala Leu Cys Phe Val Val Ser 
            580                 585                 590         


Gly Ser Leu Glu Val Ile Gln Asp Asp Glu Val Val Ala Ile Leu Gly 
        595                 600                 605             


Lys Gly Asp Val Phe Gly Asp Ile Phe Trp Lys Glu Thr Thr Leu Ala 
    610                 615                 620                 


His Ala Cys Ala Asn Val Arg Ala Leu Thr Tyr Cys Asp Leu His Ile 
625                 630                 635                 640 


Ile Lys Arg Glu Ala Leu Leu Lys Val Leu Asp Phe Tyr Thr Ala Phe 
                645                 650                 655     


Ala Asn Ser Phe Ser Arg Asn Leu Thr Leu Thr Cys Asn Leu Arg Lys 
            660                 665                 670         


Arg Ile Ile Phe Arg Lys Ile Ser Asp Val Lys Lys Glu Glu Glu Glu 
        675                 680                 685             


Arg Leu Arg Gln Lys Asn Glu Val Thr Leu Ser Ile Pro Val Asp His 
    690                 695                 700                 


Pro Val Arg Lys Leu Phe Gln Lys Phe Lys Gln Gln Lys Glu Leu Arg 
705                 710                 715                 720 


Asn Gln Gly Ser Thr Gln Gly Asp Pro Glu Arg Asn Gln Leu Gln Val 
                725                 730                 735     


Glu Ser Arg Ser Leu Gln Asn Gly Ala Ser Ile Thr Gly Thr Ser Val 
            740                 745                 750         


Val Thr Val Ser Gln Ile Thr Pro Ile Gln Thr Ser Leu Ala Tyr Val 
        755                 760                 765             


Lys Thr Ser Glu Ser Leu Lys Gln Asn Asn Arg Asp Ala Met Glu Leu 
    770                 775                 780                 


Lys Pro Asn Gly Gly Ala Asp Gln Lys Cys Leu Lys Val Asn Ser Pro 
785                 790                 795                 800 


Ile Arg Met Lys Asn Gly Asn Gly Lys Gly Trp Leu Arg Leu Lys Asn 
                805                 810                 815     


Asn Met Gly Ala His Glu Glu Lys Lys Glu Asp Trp Asn Asn Val Thr 
            820                 825                 830         


Lys Ala Glu Ser Met Gly Leu Leu Ser Glu Asp Pro Lys Ser Ser Asp 
        835                 840                 845             


Ser Glu Asn Ser Val Thr Lys Asn Pro Leu Arg Lys Thr Asp Ser Cys 
    850                 855                 860                 


Asp Ser Gly Ile Thr Lys Ser Asp Leu Arg Leu Asp Lys Ala Gly Glu 
865                 870                 875                 880 


Ala Arg Ser Pro Leu Glu His Ser Pro Ile Gln Ala Asp Ala Lys His 
                885                 890                 895     


Pro Phe Tyr Pro Ile Pro Glu Gln Ala Leu Gln Thr Thr Leu Gln Glu 
            900                 905                 910         


Val Lys His Glu Leu Lys Glu Asp Ile Gln Leu Leu Ser Cys Arg Met 
        915                 920                 925             


Thr Ala Leu Glu Lys Gln Val Ala Glu Ile Leu Lys Ile Leu Ser Glu 
    930                 935                 940                 


Lys Ser Val Pro Gln Ala Ser Ser Pro Lys Ser Gln Met Pro Leu Gln 
945                 950                 955                 960 


Val Pro Pro Gln Ile Pro Cys Gln Asp Ile Phe Ser Val Ser Arg Pro 
                965                 970                 975     


Glu Ser Pro Glu Ser Asp Lys Asp Glu Ile His Phe 
            980                 985             


<210>  5854
<211>  589
<212>  PRT
<213>  Homo sapiens

<400>  5854

Met Pro Phe Lys Ala Phe Asp Thr Phe Lys Glu Lys Ile Leu Lys Pro 
1               5                   10                  15      


Gly Lys Glu Gly Val Lys Asn Ala Val Gly Asp Ser Leu Gly Ile Leu 
            20                  25                  30          


Gln Arg Lys Ile Asp Gly Thr Thr Glu Glu Glu Asp Asn Ile Glu Leu 
        35                  40                  45              


Asn Glu Glu Gly Arg Pro Val Gln Thr Ser Arg Pro Ser Pro Pro Leu 
    50                  55                  60                  


Cys Asp Cys His Cys Cys Gly Leu Pro Lys Arg Tyr Ile Ile Ala Ile 
65                  70                  75                  80  


Met Ser Gly Leu Gly Phe Cys Ile Ser Phe Gly Ile Arg Cys Asn Leu 
                85                  90                  95      


Gly Val Ala Ile Val Glu Met Val Asn Asn Ser Thr Val Tyr Val Asp 
            100                 105                 110         


Gly Lys Pro Glu Ile Gln Thr Ala Gln Phe Asn Trp Asp Pro Glu Thr 
        115                 120                 125             


Val Gly Leu Ile His Gly Ser Phe Phe Trp Gly Tyr Ile Met Thr Gln 
    130                 135                 140                 


Ile Pro Gly Gly Phe Ile Ser Asn Lys Phe Ala Ala Asn Arg Val Phe 
145                 150                 155                 160 


Gly Ala Ala Ile Phe Leu Thr Ser Thr Leu Asn Met Phe Ile Pro Ser 
                165                 170                 175     


Ala Ala Arg Val His Tyr Gly Cys Val Met Cys Val Arg Ile Leu Gln 
            180                 185                 190         


Gly Leu Val Glu Gly Val Thr Tyr Pro Ala Cys His Gly Met Trp Ser 
        195                 200                 205             


Lys Trp Ala Pro Pro Leu Glu Arg Ser Arg Leu Ala Thr Thr Ser Phe 
    210                 215                 220                 


Cys Gly Ser Tyr Ala Gly Ala Val Val Ala Met Pro Leu Ala Gly Val 
225                 230                 235                 240 


Leu Val Gln Tyr Ile Gly Trp Ser Ser Val Phe Tyr Ile Tyr Gly Met 
                245                 250                 255     


Phe Gly Ile Ile Trp Tyr Met Phe Trp Leu Leu Gln Ala Tyr Glu Cys 
            260                 265                 270         


Pro Ala Ala His Pro Thr Ile Ser Asn Glu Glu Lys Thr Tyr Ile Glu 
        275                 280                 285             


Thr Ser Ile Gly Glu Gly Ala Asn Val Val Ser Leu Ser Lys Phe Ser 
    290                 295                 300                 


Thr Pro Trp Lys Arg Phe Phe Thr Ser Leu Pro Val Tyr Ala Ile Ile 
305                 310                 315                 320 


Val Ala Asn Phe Cys Arg Ser Trp Thr Phe Tyr Leu Leu Leu Ile Ser 
                325                 330                 335     


Gln Pro Ala Tyr Phe Glu Glu Val Phe Gly Phe Ala Ile Ser Lys Val 
            340                 345                 350         


Gly Leu Leu Ser Ala Val Pro His Met Val Met Thr Ile Val Val Pro 
        355                 360                 365             


Ile Gly Gly Gln Leu Ala Asp Tyr Leu Arg Ser Arg Gln Ile Leu Thr 
    370                 375                 380                 


Thr Thr Ala Val Arg Lys Ile Met Asn Cys Gly Gly Phe Gly Met Glu 
385                 390                 395                 400 


Ala Thr Leu Leu Leu Val Val Gly Phe Ser His Thr Lys Gly Val Ala 
                405                 410                 415     


Ile Ser Phe Leu Val Leu Ala Val Gly Phe Ser Gly Phe Ala Ile Ser 
            420                 425                 430         


Gly Phe Asn Val Asn His Leu Asp Ile Ala Pro Arg Tyr Ala Ser Ile 
        435                 440                 445             


Leu Met Gly Ile Ser Asn Gly Val Gly Thr Leu Ser Gly Met Val Cys 
    450                 455                 460                 


Pro Leu Ile Val Gly Ala Met Thr Arg His Lys Thr Arg Glu Glu Trp 
465                 470                 475                 480 


Gln Asn Val Phe Leu Ile Ala Ala Leu Val His Tyr Ser Gly Val Ile 
                485                 490                 495     


Phe Tyr Gly Val Phe Ala Ser Gly Glu Lys Gln Glu Trp Ala Asp Pro 
            500                 505                 510         


Glu Asn Leu Ser Glu Glu Lys Cys Gly Ile Ile Asp Gln Asp Glu Leu 
        515                 520                 525             


Ala Glu Glu Ile Glu Leu Asn His Glu Ser Phe Ala Ser Pro Lys Lys 
    530                 535                 540                 


Lys Met Ser Tyr Gly Ala Thr Ser Gln Asn Cys Glu Val Gln Lys Lys 
545                 550                 555                 560 


Glu Trp Lys Gly Gln Arg Gly Ala Thr Leu Asp Glu Glu Glu Leu Thr 
                565                 570                 575     


Ser Tyr Gln Asn Glu Glu Arg Asn Phe Ser Thr Ile Ser 
            580                 585                 


<210>  5855
<211>  1429
<212>  PRT
<213>  Homo sapiens

<400>  5855

Met Val Ala Ala Ala Ala Ala Thr Glu Ala Arg Leu Arg Arg Arg Thr 
1               5                   10                  15      


Ala Ala Thr Ala Ala Leu Ala Gly Arg Ser Gly Gly Pro His Trp Asp 
            20                  25                  30          


Trp Asp Val Thr Arg Ala Gly Arg Pro Gly Leu Gly Ala Gly Leu Arg 
        35                  40                  45              


Leu Pro Arg Leu Leu Ser Pro Pro Leu Arg Pro Arg Leu Leu Leu Leu 
    50                  55                  60                  


Leu Leu Leu Leu Ser Pro Pro Leu Leu Leu Leu Leu Leu Pro Cys Glu 
65                  70                  75                  80  


Ala Glu Ala Ala Ala Ala Ala Ala Ala Val Ser Gly Ser Ala Ala Ala 
                85                  90                  95      


Glu Ala Lys Glu Cys Asp Arg Pro Cys Val Asn Gly Gly Arg Cys Asn 
            100                 105                 110         


Pro Gly Thr Gly Gln Cys Val Cys Pro Ala Gly Trp Val Gly Glu Gln 
        115                 120                 125             


Cys Gln His Cys Gly Gly Arg Phe Arg Leu Thr Gly Ser Ser Gly Phe 
    130                 135                 140                 


Val Thr Asp Gly Pro Gly Asn Tyr Lys Tyr Lys Thr Lys Cys Thr Trp 
145                 150                 155                 160 


Leu Ile Glu Gly Gln Pro Asn Arg Ile Met Arg Leu Arg Phe Asn His 
                165                 170                 175     


Phe Ala Thr Glu Cys Ser Trp Asp His Leu Tyr Val Tyr Asp Gly Asp 
            180                 185                 190         


Ser Ile Tyr Ala Pro Leu Val Ala Ala Phe Ser Gly Leu Ile Val Pro 
        195                 200                 205             


Glu Arg Asp Gly Asn Glu Thr Val Pro Glu Val Val Ala Thr Ser Gly 
    210                 215                 220                 


Tyr Ala Leu Leu His Phe Phe Ser Asp Ala Ala Tyr Asn Leu Thr Gly 
225                 230                 235                 240 


Phe Asn Ile Thr Tyr Ser Phe Asp Met Cys Pro Asn Asn Cys Ser Gly 
                245                 250                 255     


Arg Gly Glu Cys Lys Ile Ser Asn Ser Ser Asp Thr Val Glu Cys Glu 
            260                 265                 270         


Cys Ser Glu Asn Trp Lys Gly Glu Ala Cys Asp Ile Pro His Cys Thr 
        275                 280                 285             


Asp Asn Cys Gly Phe Pro His Arg Gly Ile Cys Asn Ser Ser Asp Val 
    290                 295                 300                 


Arg Gly Cys Ser Cys Phe Ser Asp Trp Gln Gly Pro Gly Cys Ser Val 
305                 310                 315                 320 


Pro Val Pro Ala Asn Gln Ser Phe Trp Thr Arg Glu Glu Tyr Ser Asn 
                325                 330                 335     


Leu Lys Leu Pro Arg Ala Ser His Lys Ala Val Val Asn Gly Asn Ile 
            340                 345                 350         


Met Trp Val Val Gly Gly Tyr Met Phe Asn His Ser Asp Tyr Asn Met 
        355                 360                 365             


Val Leu Ala Tyr Asp Leu Ala Ser Arg Glu Trp Leu Pro Leu Asn Arg 
    370                 375                 380                 


Ser Val Asn Asn Val Val Val Arg Tyr Gly His Ser Leu Ala Leu Tyr 
385                 390                 395                 400 


Lys Asp Lys Ile Tyr Met Tyr Gly Gly Lys Ile Asp Ser Thr Gly Asn 
                405                 410                 415     


Val Thr Asn Glu Leu Arg Val Phe His Ile His Asn Glu Ser Trp Val 
            420                 425                 430         


Leu Leu Thr Pro Lys Ala Lys Glu Gln Tyr Ala Val Val Gly His Ser 
        435                 440                 445             


Ala His Ile Val Thr Leu Lys Asn Gly Arg Val Val Met Leu Val Ile 
    450                 455                 460                 


Phe Gly His Cys Pro Leu Tyr Gly Tyr Ile Ser Asn Val Gln Glu Tyr 
465                 470                 475                 480 


Asp Leu Asp Lys Asn Thr Trp Ser Ile Leu His Thr Gln Gly Ala Leu 
                485                 490                 495     


Val Gln Gly Gly Tyr Gly His Ser Ser Val Tyr Asp His Arg Thr Arg 
            500                 505                 510         


Ala Leu Tyr Val His Gly Gly Tyr Lys Ala Phe Ser Ala Asn Lys Tyr 
        515                 520                 525             


Arg Leu Ala Asp Asp Leu Tyr Arg Tyr Asp Val Asp Thr Gln Met Trp 
    530                 535                 540                 


Thr Ile Leu Lys Asp Ser Arg Phe Phe Arg Tyr Leu His Thr Ala Val 
545                 550                 555                 560 


Ile Val Ser Gly Thr Met Leu Val Phe Gly Gly Asn Thr His Asn Asp 
                565                 570                 575     


Thr Ser Met Ser His Gly Ala Lys Cys Phe Ser Ser Asp Phe Met Ala 
            580                 585                 590         


Tyr Asp Ile Ala Cys Asp Arg Trp Ser Val Leu Pro Arg Pro Asp Leu 
        595                 600                 605             


His His Asp Val Asn Arg Phe Gly His Ser Ala Val Leu His Asn Ser 
    610                 615                 620                 


Thr Met Tyr Val Phe Gly Gly Phe Asn Ser Leu Leu Leu Ser Asp Ile 
625                 630                 635                 640 


Leu Val Phe Thr Ser Glu Gln Cys Asp Ala His Arg Ser Glu Ala Ala 
                645                 650                 655     


Cys Leu Ala Ala Gly Pro Gly Ile Arg Cys Val Trp Asn Thr Gly Ser 
            660                 665                 670         


Ser Gln Cys Ile Ser Trp Ala Leu Ala Thr Asp Glu Gln Glu Glu Lys 
        675                 680                 685             


Leu Lys Ser Glu Cys Phe Ser Lys Arg Thr Leu Asp His Asp Arg Cys 
    690                 695                 700                 


Asp Gln His Thr Asp Cys Tyr Ser Cys Thr Ala Asn Thr Asn Asp Cys 
705                 710                 715                 720 


His Trp Cys Asn Asp His Cys Val Pro Arg Asn His Ser Cys Ser Glu 
                725                 730                 735     


Gly Gln Ile Ser Ile Phe Arg Tyr Glu Asn Cys Pro Lys Asp Asn Pro 
            740                 745                 750         


Met Tyr Tyr Cys Asn Lys Lys Thr Ser Cys Arg Ser Cys Ala Leu Asp 
        755                 760                 765             


Gln Asn Cys Gln Trp Glu Pro Arg Asn Gln Glu Cys Ile Ala Leu Pro 
    770                 775                 780                 


Glu Asn Ile Cys Gly Ile Gly Trp His Leu Val Gly Asn Ser Cys Leu 
785                 790                 795                 800 


Lys Ile Thr Thr Ala Lys Glu Asn Tyr Asp Asn Ala Lys Leu Phe Cys 
                805                 810                 815     


Arg Asn His Asn Ala Leu Leu Ala Ser Leu Thr Thr Gln Lys Lys Val 
            820                 825                 830         


Glu Phe Val Leu Lys Gln Leu Arg Ile Met Gln Ser Ser Gln Ser Met 
        835                 840                 845             


Ser Lys Leu Thr Leu Thr Pro Trp Val Gly Leu Arg Lys Ile Asn Val 
    850                 855                 860                 


Ser Tyr Trp Cys Trp Glu Asp Met Ser Pro Phe Thr Asn Ser Leu Leu 
865                 870                 875                 880 


Gln Trp Met Pro Ser Glu Pro Ser Asp Ala Gly Phe Cys Gly Ile Leu 
                885                 890                 895     


Ser Glu Pro Ser Thr Arg Gly Leu Lys Ala Ala Thr Cys Ile Asn Pro 
            900                 905                 910         


Leu Asn Gly Ser Val Cys Glu Arg Pro Ala Asn His Ser Ala Lys Gln 
        915                 920                 925             


Cys Arg Thr Pro Cys Ala Leu Arg Thr Ala Cys Gly Asp Cys Thr Ser 
    930                 935                 940                 


Gly Ser Ser Glu Cys Met Trp Cys Ser Asn Met Lys Gln Cys Val Asp 
945                 950                 955                 960 


Ser Asn Ala Tyr Val Ala Ser Phe Pro Phe Gly Gln Cys Met Glu Trp 
                965                 970                 975     


Tyr Thr Met Ser Thr Cys Pro Pro Glu Asn Cys Ser Gly Tyr Cys Thr 
            980                 985                 990         


Cys Ser His Cys Leu Glu Gln Pro  Gly Cys Gly Trp Cys  Thr Asp Pro 
        995                 1000                 1005             


Ser Asn  Thr Gly Lys Gly Lys  Cys Ile Glu Gly Ser  Tyr Lys Gly 
    1010                 1015                 1020             


Pro Val  Lys Met Pro Ser Gln  Ala Pro Thr Gly Asn  Phe Tyr Pro 
    1025                 1030                 1035             


Gln Pro  Leu Leu Asn Ser Ser  Met Cys Leu Glu Asp  Ser Arg Tyr 
    1040                 1045                 1050             


Asn Trp  Ser Phe Ile His Cys  Pro Ala Cys Gln Cys  Asn Gly His 
    1055                 1060                 1065             


Ser Lys  Cys Ile Asn Gln Ser  Ile Cys Glu Lys Cys  Glu Asn Leu 
    1070                 1075                 1080             


Thr Thr  Gly Lys His Cys Glu  Thr Cys Ile Ser Gly  Phe Tyr Gly 
    1085                 1090                 1095             


Asp Pro  Thr Asn Gly Gly Lys  Cys Gln Pro Cys Lys  Cys Asn Gly 
    1100                 1105                 1110             


His Ala  Ser Leu Cys Asn Thr  Asn Thr Gly Lys Cys  Phe Cys Thr 
    1115                 1120                 1125             


Thr Lys  Gly Val Lys Gly Asp  Glu Cys Gln Leu Cys  Glu Val Glu 
    1130                 1135                 1140             


Asn Arg  Tyr Gln Gly Asn Pro  Leu Arg Gly Thr Cys  Tyr Tyr Thr 
    1145                 1150                 1155             


Leu Leu  Ile Asp Tyr Gln Phe  Thr Phe Ser Leu Ser  Gln Glu Asp 
    1160                 1165                 1170             


Asp Arg  Tyr Tyr Thr Ala Ile  Asn Phe Val Ala Thr  Pro Asp Glu 
    1175                 1180                 1185             


Gln Asn  Arg Asp Leu Asp Met  Phe Ile Asn Ala Ser  Lys Asn Phe 
    1190                 1195                 1200             


Asn Leu  Asn Ile Thr Trp Ala  Ala Ser Phe Ser Ala  Gly Thr Gln 
    1205                 1210                 1215             


Ala Gly  Glu Glu Met Pro Val  Val Ser Lys Thr Asn  Ile Lys Glu 
    1220                 1225                 1230             


Tyr Lys  Asp Ser Phe Ser Asn  Glu Lys Phe Asp Phe  Arg Asn His 
    1235                 1240                 1245             


Pro Asn  Ile Thr Phe Phe Val  Tyr Val Ser Asn Phe  Thr Trp Pro 
    1250                 1255                 1260             


Ile Lys  Ile Gln Ile Ala Phe  Ser Gln His Ser Asn  Phe Met Asp 
    1265                 1270                 1275             


Leu Val  Gln Phe Phe Val Thr  Phe Phe Ser Cys Phe  Leu Ser Leu 
    1280                 1285                 1290             


Leu Leu  Val Ala Ala Val Val  Trp Lys Ile Lys Gln  Ser Cys Trp 
    1295                 1300                 1305             


Ala Ser  Arg Arg Arg Glu Gln  Leu Leu Arg Glu Met  Gln Gln Met 
    1310                 1315                 1320             


Ala Ser  Arg Pro Phe Ala Ser  Val Asn Val Ala Leu  Glu Thr Asp 
    1325                 1330                 1335             


Glu Glu  Pro Pro Asp Leu Ile  Gly Gly Ser Ile Lys  Thr Val Pro 
    1340                 1345                 1350             


Lys Pro  Ile Ala Leu Glu Pro  Cys Phe Gly Asn Lys  Ala Ala Val 
    1355                 1360                 1365             


Leu Ser  Val Phe Val Arg Leu  Pro Arg Gly Leu Gly  Gly Ile Pro 
    1370                 1375                 1380             


Pro Pro  Gly Gln Ser Gly Leu  Ala Val Ala Ser Ala  Leu Val Asp 
    1385                 1390                 1395             


Ile Ser  Gln Gln Met Pro Ile  Val Tyr Lys Glu Lys  Ser Gly Ala 
    1400                 1405                 1410             


Val Arg  Asn Arg Lys Gln Gln  Pro Pro Ala Gln Pro  Gly Thr Cys 
    1415                 1420                 1425             


Ile 
    


<210>  5856
<211>  1272
<212>  PRT
<213>  Homo sapiens

<400>  5856

Met Val Ala Ala Ala Ala Ala Thr Glu Ala Arg Leu Arg Arg Arg Thr 
1               5                   10                  15      


Ala Ala Thr Ala Ala Leu Ala Gly Arg Ser Gly Gly Pro His Trp Asp 
            20                  25                  30          


Trp Asp Val Thr Arg Ala Gly Arg Pro Gly Leu Gly Ala Gly Leu Arg 
        35                  40                  45              


Leu Pro Arg Leu Leu Ser Pro Pro Leu Arg Pro Arg Leu Leu Leu Leu 
    50                  55                  60                  


Leu Leu Leu Leu Ser Pro Pro Leu Leu Leu Leu Leu Leu Pro Cys Glu 
65                  70                  75                  80  


Ala Glu Ala Ala Ala Ala Ala Ala Ala Val Ser Gly Ser Ala Ala Ala 
                85                  90                  95      


Glu Ala Lys Glu Cys Asp Arg Pro Cys Val Asn Gly Gly Arg Cys Asn 
            100                 105                 110         


Pro Gly Thr Gly Gln Cys Val Cys Pro Ala Gly Trp Val Gly Glu Gln 
        115                 120                 125             


Cys Gln His Cys Gly Gly Arg Phe Arg Leu Thr Gly Ser Ser Gly Phe 
    130                 135                 140                 


Val Thr Asp Gly Pro Gly Asn Tyr Lys Tyr Lys Thr Lys Cys Thr Trp 
145                 150                 155                 160 


Leu Ile Glu Gly Gln Pro Asn Arg Ile Met Arg Leu Arg Phe Asn His 
                165                 170                 175     


Phe Ala Thr Glu Cys Ser Trp Asp His Leu Tyr Val Tyr Asp Gly Asp 
            180                 185                 190         


Ser Ile Tyr Ala Pro Leu Val Ala Ala Phe Ser Gly Leu Ile Val Pro 
        195                 200                 205             


Glu Arg Asp Gly Asn Glu Thr Val Pro Glu Val Val Ala Thr Ser Gly 
    210                 215                 220                 


Tyr Ala Leu Leu His Phe Phe Ser Asp Ala Ala Tyr Asn Leu Thr Gly 
225                 230                 235                 240 


Phe Asn Ile Thr Tyr Ser Phe Asp Met Cys Pro Asn Asn Cys Ser Gly 
                245                 250                 255     


Arg Gly Glu Cys Lys Ile Ser Asn Ser Ser Asp Thr Val Glu Cys Glu 
            260                 265                 270         


Cys Ser Glu Asn Trp Lys Gly Glu Ala Cys Asp Ile Pro His Cys Thr 
        275                 280                 285             


Asp Asn Cys Gly Phe Pro His Arg Gly Ile Cys Asn Ser Ser Asp Val 
    290                 295                 300                 


Arg Gly Cys Ser Cys Phe Ser Asp Trp Gln Gly Pro Gly Cys Ser Val 
305                 310                 315                 320 


Pro Val Pro Ala Asn Gln Ser Phe Trp Thr Arg Glu Glu Tyr Ser Asn 
                325                 330                 335     


Leu Lys Leu Pro Arg Ala Ser His Lys Ala Val Val Asn Gly Asn Ile 
            340                 345                 350         


Met Trp Val Val Gly Gly Tyr Met Phe Asn His Ser Asp Tyr Asn Met 
        355                 360                 365             


Val Leu Ala Tyr Asp Leu Ala Ser Arg Glu Trp Leu Pro Leu Asn Arg 
    370                 375                 380                 


Ser Val Asn Asn Val Val Val Arg Tyr Gly His Ser Leu Ala Leu Tyr 
385                 390                 395                 400 


Lys Asp Lys Ile Tyr Met Tyr Gly Gly Lys Ile Asp Ser Thr Gly Asn 
                405                 410                 415     


Val Thr Asn Glu Leu Arg Val Phe His Ile His Asn Glu Ser Trp Val 
            420                 425                 430         


Leu Leu Thr Pro Lys Ala Lys Glu Gln Tyr Ala Val Val Gly His Ser 
        435                 440                 445             


Ala His Ile Val Thr Leu Lys Asn Gly Arg Val Val Met Leu Val Ile 
    450                 455                 460                 


Phe Gly His Cys Pro Leu Tyr Gly Tyr Ile Ser Asn Val Gln Glu Tyr 
465                 470                 475                 480 


Asp Leu Asp Lys Asn Thr Trp Ser Ile Leu His Thr Gln Gly Ala Leu 
                485                 490                 495     


Val Gln Gly Gly Tyr Gly His Ser Ser Val Tyr Asp His Arg Thr Arg 
            500                 505                 510         


Ala Leu Tyr Val His Gly Gly Tyr Lys Ala Phe Ser Ala Asn Lys Tyr 
        515                 520                 525             


Arg Leu Ala Asp Asp Leu Tyr Arg Tyr Asp Val Asp Thr Gln Met Trp 
    530                 535                 540                 


Thr Ile Leu Lys Asp Ser Arg Phe Phe Arg Tyr Leu His Thr Ala Val 
545                 550                 555                 560 


Ile Val Ser Gly Thr Met Leu Val Phe Gly Gly Asn Thr His Asn Asp 
                565                 570                 575     


Thr Ser Met Ser His Gly Ala Lys Cys Phe Ser Ser Asp Phe Met Ala 
            580                 585                 590         


Tyr Asp Ile Ala Cys Asp Arg Trp Ser Val Leu Pro Arg Pro Asp Leu 
        595                 600                 605             


His His Asp Val Asn Arg Phe Gly His Ser Ala Val Leu His Asn Ser 
    610                 615                 620                 


Thr Met Tyr Val Phe Gly Gly Phe Asn Ser Leu Leu Leu Ser Asp Ile 
625                 630                 635                 640 


Leu Val Phe Thr Ser Glu Gln Cys Asp Ala His Arg Ser Glu Ala Ala 
                645                 650                 655     


Cys Leu Ala Ala Gly Pro Gly Ile Arg Cys Val Trp Asn Thr Gly Ser 
            660                 665                 670         


Ser Gln Cys Ile Ser Trp Ala Leu Ala Thr Asp Glu Gln Glu Glu Lys 
        675                 680                 685             


Leu Lys Ser Glu Cys Phe Ser Lys Arg Thr Leu Asp His Asp Arg Cys 
    690                 695                 700                 


Asp Gln His Thr Asp Cys Tyr Ser Cys Thr Ala Asn Thr Asn Asp Cys 
705                 710                 715                 720 


His Trp Cys Asn Asp His Cys Val Pro Arg Asn His Ser Cys Ser Glu 
                725                 730                 735     


Gly Gln Ile Ser Ile Phe Arg Tyr Glu Asn Cys Pro Lys Asp Asn Pro 
            740                 745                 750         


Met Tyr Tyr Cys Asn Lys Lys Thr Ser Cys Arg Ser Cys Ala Leu Asp 
        755                 760                 765             


Gln Asn Cys Gln Trp Glu Pro Arg Asn Gln Glu Cys Ile Ala Leu Pro 
    770                 775                 780                 


Glu Asn Ile Cys Gly Ile Gly Trp His Leu Val Gly Asn Ser Cys Leu 
785                 790                 795                 800 


Lys Ile Thr Thr Ala Lys Glu Asn Tyr Asp Asn Ala Lys Leu Phe Cys 
                805                 810                 815     


Arg Asn His Asn Ala Leu Leu Ala Ser Leu Thr Thr Gln Lys Lys Val 
            820                 825                 830         


Glu Phe Val Leu Lys Gln Leu Arg Ile Met Gln Ser Ser Gln Ser Met 
        835                 840                 845             


Ser Lys Leu Thr Leu Thr Pro Trp Val Gly Leu Arg Lys Ile Asn Val 
    850                 855                 860                 


Ser Tyr Trp Cys Trp Glu Asp Met Ser Pro Phe Thr Asn Ser Leu Leu 
865                 870                 875                 880 


Gln Trp Met Pro Ser Glu Pro Ser Asp Ala Gly Phe Cys Gly Ile Leu 
                885                 890                 895     


Ser Glu Pro Ser Thr Arg Gly Leu Lys Ala Ala Thr Cys Ile Asn Pro 
            900                 905                 910         


Leu Asn Gly Ser Val Cys Glu Arg Pro Ala Asn His Ser Ala Lys Gln 
        915                 920                 925             


Cys Arg Thr Pro Cys Ala Leu Arg Thr Ala Cys Gly Asp Cys Thr Ser 
    930                 935                 940                 


Gly Ser Ser Glu Cys Met Trp Cys Ser Asn Met Lys Gln Cys Val Asp 
945                 950                 955                 960 


Ser Asn Ala Tyr Val Ala Ser Phe Pro Phe Gly Gln Cys Met Glu Trp 
                965                 970                 975     


Tyr Thr Met Ser Thr Cys Pro Pro Glu Asn Cys Ser Gly Tyr Cys Thr 
            980                 985                 990         


Cys Ser His Cys Leu Glu Gln Pro  Gly Cys Gly Trp Cys  Thr Asp Pro 
        995                 1000                 1005             


Ser Asn  Thr Gly Lys Gly Lys  Cys Ile Glu Gly Ser  Tyr Lys Gly 
    1010                 1015                 1020             


Pro Val  Lys Met Pro Ser Gln  Ala Pro Thr Gly Asn  Phe Tyr Pro 
    1025                 1030                 1035             


Gln Pro  Leu Leu Asn Ser Ser  Met Cys Leu Glu Asp  Ser Arg Tyr 
    1040                 1045                 1050             


Asn Trp  Ser Phe Ile His Cys  Pro Ala Cys Gln Cys  Asn Gly His 
    1055                 1060                 1065             


Ser Lys  Cys Ile Asn Gln Ser  Ile Cys Glu Lys Cys  Glu Asn Leu 
    1070                 1075                 1080             


Thr Thr  Gly Lys His Cys Glu  Thr Cys Ile Ser Gly  Phe Tyr Gly 
    1085                 1090                 1095             


Asp Pro  Thr Asn Gly Gly Lys  Cys Gln Pro Cys Lys  Cys Asn Gly 
    1100                 1105                 1110             


His Ala  Ser Leu Cys Asn Thr  Asn Thr Gly Lys Cys  Phe Cys Thr 
    1115                 1120                 1125             


Thr Lys  Gly Val Lys Gly Asp  Glu Cys Gln Leu Cys  Glu Val Glu 
    1130                 1135                 1140             


Asn Arg  Tyr Gln Gly Asn Pro  Leu Arg Gly Thr Cys  Tyr Tyr Thr 
    1145                 1150                 1155             


Leu Leu  Ile Asp Tyr Gln Phe  Thr Phe Ser Leu Ser  Gln Glu Asp 
    1160                 1165                 1170             


Asp Arg  Tyr Tyr Thr Ala Ile  Asn Phe Val Ala Thr  Pro Asp Glu 
    1175                 1180                 1185             


Gln Asn  Arg Asp Leu Asp Met  Phe Ile Asn Ala Ser  Lys Asn Phe 
    1190                 1195                 1200             


Asn Leu  Asn Ile Thr Trp Ala  Ala Ser Phe Ser Ala  Gly Thr Gln 
    1205                 1210                 1215             


Ala Gly  Glu Glu Met Pro Val  Val Ser Lys Thr Asn  Ile Lys Glu 
    1220                 1225                 1230             


Tyr Lys  Asp Ser Phe Ser Asn  Glu Lys Phe Asp Phe  Arg Asn His 
    1235                 1240                 1245             


Pro Asn  Ile Thr Phe Phe Val  Tyr Val Ser Asn Phe  Thr Trp Pro 
    1250                 1255                 1260             


Ile Lys  Ile Gln Val Gln Thr  Glu Gln 
    1265                 1270         


<210>  5857
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  5857

Met Ala Ser Thr Ala Val Gln Leu Leu Gly Phe Leu Leu Ser Phe Leu 
1               5                   10                  15      


Gly Met Val Gly Thr Leu Ile Thr Thr Ile Leu Pro His Trp Arg Arg 
            20                  25                  30          


Thr Ala His Val Gly Thr Asn Ile Leu Thr Ala Val Ser Tyr Leu Lys 
        35                  40                  45              


Gly Leu Trp Met Glu Cys Val Trp His Ser Thr Gly Ile Tyr Gln Cys 
    50                  55                  60                  


Gln Ile Tyr Arg Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala 
65                  70                  75                  80  


Arg Ala Leu Met Val Ile Ser Cys Leu Leu Ser Gly Ile Ala Cys Ala 
                85                  90                  95      


Cys Ala Val Ile Gly Met Lys Cys Thr Arg Cys Ala Lys Gly Thr Pro 
            100                 105                 110         


Ala Lys Thr Thr Phe Ala Ile Leu Gly Gly Thr Leu Phe Ile Leu Ala 
        115                 120                 125             


Gly Leu Leu Cys Met Val Ala Val Ser Trp Thr Thr Asn Asp Val Val 
    130                 135                 140                 


Gln Asn Phe Tyr Asn Pro Leu Leu Pro Ser Gly Met Lys Phe Glu Ile 
145                 150                 155                 160 


Gly Gln Ala Leu Tyr Leu Gly Phe Ile Ser Ser Ser Leu Ser Leu Ile 
                165                 170                 175     


Gly Gly Thr Leu Leu Cys Leu Ser Cys Gln Asp Glu Ala Pro Tyr Arg 
            180                 185                 190         


Pro Tyr Gln Ala Pro Pro Arg Ala Thr Thr Thr Thr Ala Asn Thr Ala 
        195                 200                 205             


Pro Ala Tyr Gln Pro Pro Ala Ala Tyr Lys Asp Asn Arg Ala Pro Ser 
    210                 215                 220                 


Val Thr Ser Ala Thr His Ser Gly Tyr Arg Leu Asn Asp Tyr Val 
225                 230                 235                 


<210>  5858
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  5858

Met Gly Arg Pro Arg Pro Arg Ala Ala Lys Thr Trp Met Phe Leu Leu 
1               5                   10                  15      


Leu Leu Gly Gly Ala Trp Ala Ala Cys Gly Ser Leu Asp Leu Leu Thr 
            20                  25                  30          


Lys Leu Tyr Ala Glu Asn Leu Pro Cys Val His Leu Asn Pro Gln Trp 
        35                  40                  45              


Pro Ser Gln Pro Ser His Cys Pro Arg Gly Trp Arg Ser Asn Pro Leu 
    50                  55                  60                  


Pro Pro Ala Ala Gly His Ser Arg Ala Gln Glu Asp Lys Val Leu Gly 
65                  70                  75                  80  


Gly His Glu Cys Gln Pro His Ser Gln Pro Trp Gln Ala Ala Leu Phe 
                85                  90                  95      


Gln Gly Gln Gln Leu Leu Cys Gly Gly Val Leu Val Gly Gly Asn Trp 
            100                 105                 110         


Val Leu Thr Ala Ala His Cys Lys Lys Pro Lys Tyr Thr Val Arg Leu 
        115                 120                 125             


Gly Asp His Ser Leu Gln Asn Lys Asp Gly Pro Glu Gln Glu Ile Pro 
    130                 135                 140                 


Val Val Gln Ser Ile Pro His Pro Cys Tyr Asn Ser Ser Asp Val Glu 
145                 150                 155                 160 


Asp His Asn His Asp Leu Met Leu Leu Gln Leu Arg Asp Gln Ala Ser 
                165                 170                 175     


Leu Gly Ser Lys Val Lys Pro Ile Ser Leu Ala Asp His Cys Thr Gln 
            180                 185                 190         


Pro Gly Gln Lys Cys Thr Val Ser Gly Trp Gly Thr Val Thr Ser Pro 
        195                 200                 205             


Arg Glu Asn Phe Pro Asp Thr Leu Asn Cys Ala Glu Val Lys Ile Phe 
    210                 215                 220                 


Pro Gln Lys Lys Cys Glu Asp Ala Tyr Pro Gly Gln Ile Thr Asp Gly 
225                 230                 235                 240 


Met Val Cys Ala Gly Ser Ser Lys Gly Ala Asp Thr Cys Gln Gly Asp 
                245                 250                 255     


Ser Gly Gly Pro Leu Val Cys Asp Gly Ala Leu Gln Gly Ile Thr Ser 
            260                 265                 270         


Trp Gly Ser Asp Pro Cys Gly Arg Ser Asp Lys Pro Gly Val Tyr Thr 
        275                 280                 285             


Asn Ile Cys Arg Tyr Leu Asp Trp Ile Lys Lys Ile Ile Gly Ser Lys 
    290                 295                 300                 


Gly 
305 


<210>  5859
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  5859

Met Gly Arg Pro Arg Pro Arg Ala Ala Lys Thr Trp Met Phe Leu Leu 
1               5                   10                  15      


Leu Leu Gly Gly Ala Trp Ala Glu Asn Phe Pro Asp Thr Leu Asn Cys 
            20                  25                  30          


Ala Glu Val Lys Ile Phe Pro Gln Lys Lys Cys Glu Asp Ala Tyr Pro 
        35                  40                  45              


Gly Gln Ile Thr Asp Gly Met Val Cys Ala Gly Ser Ser Lys Gly Ala 
    50                  55                  60                  


Asp Thr Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Asp Gly Ala 
65                  70                  75                  80  


Leu Gln Gly Ile Thr Ser Trp Gly Ser Asp Pro Cys Gly Arg Ser Asp 
                85                  90                  95      


Lys Pro Gly Val Tyr Thr Asn Ile Cys Arg Tyr Leu Asp Trp Ile Lys 
            100                 105                 110         


Lys Ile Ile Gly Ser Lys Gly 
        115                 


<210>  5860
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  5860

Met Gly Arg Pro Arg Pro Arg Ala Ala Lys Thr Trp Met Phe Leu Leu 
1               5                   10                  15      


Leu Leu Gly Gly Ala Trp Ala Gly Arg Phe Trp Arg Pro Pro Gly Val 
            20                  25                  30          


<210>  5861
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  5861

Met Val Lys Leu Leu Val Ala Lys Ile Leu Cys Met Val Gly Val Phe 
1               5                   10                  15      


Phe Phe Met Leu Leu Gly Ser Leu Leu Pro Val Lys Ile Ile Glu Thr 
            20                  25                  30          


Asp Phe Glu Lys Ala His Arg Ser Lys Lys Ile Leu Ser Leu Cys Asn 
        35                  40                  45              


Thr Phe Gly Gly Gly Val Phe Leu Ala Thr Cys Phe Asn Ala Leu Leu 
    50                  55                  60                  


Pro Ala Val Arg Glu Lys Leu Gln Lys Val Leu Ser Leu Gly His Ile 
65                  70                  75                  80  


Ser Thr Asp Tyr Pro Leu Ala Glu Thr Ile Leu Leu Leu Gly Phe Phe 
                85                  90                  95      


Met Thr Val Phe Leu Glu Gln Leu Ile Leu Thr Phe Arg Lys Glu Lys 
            100                 105                 110         


Pro Ser Phe Ile Asp Leu Glu Thr Phe Asn Ala Gly Ser Asp Val Gly 
        115                 120                 125             


Ser Asp Ser Glu Tyr Glu Ser Pro Phe Met Gly Gly Ala Arg Gly His 
    130                 135                 140                 


Ala Leu Tyr Val Glu Pro His Gly His Gly Pro Ser Leu Ser Val Gln 
145                 150                 155                 160 


Gly Leu Ser Arg Ala Ser Pro Val Arg Leu Leu Ser Leu Ala Phe Ala 
                165                 170                 175     


Leu Ser Ala His Ser Val Phe Glu Gly Leu Ala Leu Gly Leu Gln Glu 
            180                 185                 190         


Glu Gly Glu Lys Val Val Ser Leu Phe Val Gly Val Ala Val His Glu 
        195                 200                 205             


Thr Leu Val Ala Val Ala Leu Gly Ile Ser Met Ala Arg Ser Ala Met 
    210                 215                 220                 


Pro Leu Arg Asp Ala Ala Lys Leu Ala Val Thr Val Ser Ala Met Ile 
225                 230                 235                 240 


Pro Leu Gly Ile Gly Leu Gly Leu Gly Ile Glu Ser Ala Gln Gly Val 
                245                 250                 255     


Pro Gly Ser Val Ala Ser Val Leu Leu Gln Gly Leu Ala Gly Gly Thr 
            260                 265                 270         


Phe Leu Phe Ile Thr Phe Leu Glu Ile Leu Ala Lys Glu Leu Glu Glu 
        275                 280                 285             


Lys Ser Asp Arg Leu Leu Lys Val Leu Phe Leu Val Leu Gly Tyr Thr 
    290                 295                 300                 


Val Leu Ala Gly Met Val Phe Leu Lys Trp 
305                 310                 


<210>  5862
<211>  483
<212>  PRT
<213>  Homo sapiens

<400>  5862

Met Ala Thr Leu Gly His Thr Phe Pro Phe Tyr Ala Gly Pro Lys Pro 
1               5                   10                  15      


Thr Phe Pro Met Asp Thr Thr Leu Ala Ser Ile Ile Met Ile Phe Leu 
            20                  25                  30          


Thr Ala Leu Ala Thr Phe Ile Val Ile Leu Pro Gly Ile Arg Gly Lys 
        35                  40                  45              


Thr Arg Leu Phe Trp Leu Leu Arg Val Val Thr Ser Leu Phe Ile Gly 
    50                  55                  60                  


Ala Ala Ile Leu Ala Val Asn Phe Ser Ser Glu Trp Ser Val Gly Gln 
65                  70                  75                  80  


Val Ser Thr Asn Thr Ser Tyr Lys Ala Phe Ser Ser Glu Trp Ile Ser 
                85                  90                  95      


Ala Asp Ile Gly Leu Gln Val Gly Leu Gly Gly Val Asn Ile Thr Leu 
            100                 105                 110         


Thr Gly Thr Pro Val Gln Gln Leu Asn Glu Thr Ile Asn Tyr Asn Glu 
        115                 120                 125             


Glu Phe Thr Trp Arg Leu Gly Glu Asn Tyr Ala Glu Glu Tyr Ala Lys 
    130                 135                 140                 


Ala Leu Glu Lys Gly Leu Pro Asp Pro Val Leu Tyr Leu Ala Glu Lys 
145                 150                 155                 160 


Phe Thr Pro Arg Ser Pro Cys Gly Leu Tyr Arg Gln Tyr Arg Leu Ala 
                165                 170                 175     


Gly His Tyr Thr Ser Ala Met Leu Trp Val Ala Phe Leu Cys Trp Leu 
            180                 185                 190         


Leu Ala Asn Val Met Leu Ser Met Pro Val Leu Val Tyr Gly Gly Tyr 
        195                 200                 205             


Met Leu Leu Ala Thr Gly Ile Phe Gln Leu Leu Ala Leu Leu Phe Phe 
    210                 215                 220                 


Ser Met Ala Thr Ser Leu Thr Ser Pro Cys Pro Leu His Leu Gly Ala 
225                 230                 235                 240 


Ser Val Leu His Thr His His Gly Pro Ala Phe Trp Ile Thr Leu Thr 
                245                 250                 255     


Thr Gly Leu Leu Cys Val Leu Leu Gly Leu Ala Met Ala Val Ala His 
            260                 265                 270         


Arg Met Gln Pro His Arg Leu Lys Ala Phe Phe Asn Gln Ser Val Asp 
        275                 280                 285             


Glu Asp Pro Met Leu Glu Trp Ser Pro Glu Glu Gly Gly Leu Leu Ser 
    290                 295                 300                 


Pro Arg Tyr Arg Ser Met Ala Asp Ser Pro Lys Ser Gln Asp Ile Pro 
305                 310                 315                 320 


Leu Ser Glu Ala Ser Ser Thr Lys Ala Tyr Tyr Arg Pro Arg Arg Leu 
                325                 330                 335     


Ser Leu Val Pro Ala Asp Val Arg Gly Leu Ala Pro Ala Ala Leu Ser 
            340                 345                 350         


Ala Leu Pro Gly Ala Leu Leu Ala Gln Ala Trp Arg Ala Leu Leu Pro 
        355                 360                 365             


Gly Leu Arg Cys Pro Lys Ala Gly Lys Glu Ser Arg Leu Gly Pro Pro 
    370                 375                 380                 


His Ser Pro Trp Arg Phe Gly Pro Glu Gly Cys Glu Glu Arg Trp Ala 
385                 390                 395                 400 


Glu His Thr Gly Asp Ser Pro Arg Pro Leu Arg Gly Arg Gly Thr Gly 
                405                 410                 415     


Arg Leu Trp Arg Trp Gly Ser Lys Glu Arg Arg Ala Cys Gly Val Arg 
            420                 425                 430         


Ala Met Leu Pro Arg Leu Val Ser Asn Ser Gly Leu Lys Arg Pro Ser 
        435                 440                 445             


Cys Leu Asp Leu Pro Lys Cys Trp Asp Tyr Arg Arg Asp Ala Arg Ala 
    450                 455                 460                 


Phe Phe His Leu Leu Glu Pro Thr Pro Cys Val Thr Ser Arg His Thr 
465                 470                 475                 480 


Pro Leu Ile 
            


<210>  5863
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  5863

Met Ala Ala Asp Gly Glu Arg Ser Pro Leu Leu Ser Glu Pro Ile Asp 
1               5                   10                  15      


Gly Gly Ala Gly Gly Asn Gly Leu Val Gly Pro Gly Gly Ser Gly Ala 
            20                  25                  30          


Gly Pro Gly Gly Gly Leu Thr Pro Ser Ala Pro Pro Tyr Gly Ala Ala 
        35                  40                  45              


Phe Pro Pro Phe Pro Glu Gly His Pro Ala Val Leu Pro Gly Glu Asp 
    50                  55                  60                  


Pro Pro Pro Tyr Ser Pro Leu Thr Ser Pro Asp Ser Gly Ser Ala Pro 
65                  70                  75                  80  


Met Ile Thr Cys Arg Val Cys Gln Ser Leu Ile Asn Val Glu Gly Lys 
                85                  90                  95      


Met His Gln His Val Val Lys Cys Gly Val Cys Asn Glu Ala Thr Pro 
            100                 105                 110         


Ile Lys Asn Ala Pro Pro Gly Lys Lys Tyr Val Arg Cys Pro Cys Asn 
        115                 120                 125             


Cys Leu Leu Ile Cys Lys Val Thr Ser Gln Arg Ile Ala Cys Pro Arg 
    130                 135                 140                 


Pro Tyr Cys Lys Arg Ile Ile Asn Leu Gly Pro Val His Pro Gly Pro 
145                 150                 155                 160 


Leu Ser Pro Glu Pro Gln Pro Met Gly Val Arg Val Ile Cys Gly His 
                165                 170                 175     


Cys Lys Asn Thr Phe Leu Trp Thr Glu Phe Thr Asp Arg Thr Leu Ala 
            180                 185                 190         


Arg Cys Pro His Cys Arg Lys Val Ser Ser Ile Gly Arg Arg Tyr Pro 
        195                 200                 205             


Arg Lys Arg Cys Ile Cys Cys Phe Leu Leu Gly Leu Leu Leu Ala Val 
    210                 215                 220                 


Thr Ala Thr Gly Leu Ala Phe Gly Thr Trp Lys His Ala Arg Arg Tyr 
225                 230                 235                 240 


Gly Gly Ile Tyr Ala Ala Trp Ala Phe Val Ile Leu Leu Ala Val Leu 
                245                 250                 255     


Cys Leu Gly Arg Ala Leu Tyr Trp Ala Cys Met Lys Val Ser His Pro 
            260                 265                 270         


Val Gln Asn Phe Ser 
        275         


<210>  5864
<211>  963
<212>  PRT
<213>  Homo sapiens

<400>  5864

Met Pro Gly Ala Gly Ala Arg Ala Glu Glu Gly Gly Gly Gly Gly Glu 
1               5                   10                  15      


Gly Ala Ala Gln Gly Ala Ala Ala Glu Pro Gly Ala Gly Pro Ala Arg 
            20                  25                  30          


Glu Pro Ala Arg Leu Cys Gly Tyr Leu Gln Lys Leu Ser Gly Lys Gly 
        35                  40                  45              


Pro Leu Arg Gly Tyr Arg Ser Arg Trp Phe Val Phe Asp Ala Arg Arg 
    50                  55                  60                  


Cys Tyr Leu Tyr Tyr Phe Lys Ser Pro Gln Asp Ala Leu Pro Leu Gly 
65                  70                  75                  80  


His Leu Asp Ile Ala Asp Ala Cys Phe Ser Tyr Gln Gly Pro Asp Glu 
                85                  90                  95      


Ala Ala Glu Pro Gly Thr Glu Pro Pro Ala His Phe Gln Val His Ser 
            100                 105                 110         


Ala Gly Ala Val Thr Val Leu Lys Ala Pro Asn Arg Gln Leu Met Thr 
        115                 120                 125             


Tyr Trp Leu Gln Glu Leu Gln Gln Lys Arg Trp Glu Tyr Cys Asn Ser 
    130                 135                 140                 


Leu Asp Met Val Lys Trp Asp Ser Arg Thr Ser Pro Thr Pro Gly Asp 
145                 150                 155                 160 


Phe Pro Lys Gly Leu Val Ala Arg Asp Asn Thr Asp Leu Ile Tyr Pro 
                165                 170                 175     


His Pro Asn Ala Ser Ala Glu Lys Ala Arg Asn Val Leu Ala Val Glu 
            180                 185                 190         


Thr Val Pro Gly Glu Leu Val Gly Glu Gln Ala Ala Asn Gln Pro Ala 
        195                 200                 205             


Pro Gly His Pro Asn Ser Ile Asn Phe Tyr Ser Leu Lys Gln Trp Gly 
    210                 215                 220                 


Asn Glu Leu Lys Asn Ser Met Ser Ser Phe Arg Pro Gly Arg Gly His 
225                 230                 235                 240 


Asn Asp Ser Arg Arg Thr Val Phe Tyr Thr Asn Glu Glu Trp Glu Leu 
                245                 250                 255     


Leu Asp Pro Thr Pro Lys Asp Leu Glu Glu Ser Ile Val Gln Glu Glu 
            260                 265                 270         


Lys Lys Lys Leu Thr Pro Glu Gly Asn Lys Gly Val Thr Gly Ser Gly 
        275                 280                 285             


Phe Pro Phe Asp Phe Gly Arg Asn Pro Tyr Lys Gly Lys Arg Pro Leu 
    290                 295                 300                 


Lys Asp Ile Ile Gly Ser Tyr Lys Asn Arg His Ser Ser Gly Asp Pro 
305                 310                 315                 320 


Ser Ser Glu Gly Thr Ser Gly Ser Gly Ser Val Ser Ile Arg Lys Pro 
                325                 330                 335     


Ala Ser Glu Met Gln Leu Gln Val Gln Ser Gln Gln Glu Glu Leu Glu 
            340                 345                 350         


Gln Leu Lys Lys Asp Leu Ser Ser Gln Lys Glu Leu Val Arg Leu Leu 
        355                 360                 365             


Gln Gln Thr Val Arg Ser Ser Gln Tyr Asp Lys Tyr Phe Thr Ser Ser 
    370                 375                 380                 


Arg Leu Cys Glu Gly Val Pro Lys Asp Thr Leu Glu Leu Leu His Gln 
385                 390                 395                 400 


Lys Asp Asp Gln Ile Leu Gly Leu Thr Ser Gln Leu Glu Arg Phe Ser 
                405                 410                 415     


Leu Glu Lys Glu Ser Leu Gln Gln Glu Val Arg Thr Leu Lys Ser Lys 
            420                 425                 430         


Val Gly Glu Leu Asn Glu Gln Leu Gly Met Leu Met Glu Thr Ile Gln 
        435                 440                 445             


Ala Lys Asp Glu Val Ile Ile Lys Leu Ser Glu Gly Glu Gly Asn Gly 
    450                 455                 460                 


Pro Pro Pro Thr Val Ala Pro Ser Ser Pro Ser Val Val Pro Val Ala 
465                 470                 475                 480 


Arg Asp Gln Leu Glu Leu Asp Arg Leu Lys Asp Asn Leu Gln Gly Tyr 
                485                 490                 495     


Lys Thr Gln Asn Lys Phe Leu Asn Lys Glu Ile Leu Glu Leu Ser Ala 
            500                 505                 510         


Leu Arg Arg Asn Ala Glu Arg Arg Glu Arg Asp Leu Met Ala Lys Tyr 
        515                 520                 525             


Ser Ser Leu Glu Ala Lys Leu Cys Gln Ile Glu Ser Lys Tyr Leu Ile 
    530                 535                 540                 


Leu Leu Gln Glu Met Lys Thr Pro Val Cys Ser Glu Asp Gln Gly Pro 
545                 550                 555                 560 


Thr Arg Glu Val Ile Ala Gln Leu Leu Glu Asp Ala Leu Gln Val Glu 
                565                 570                 575     


Ser Gln Glu Gln Pro Glu Gln Ala Phe Val Lys Pro His Leu Val Ser 
            580                 585                 590         


Glu Tyr Asp Ile Tyr Gly Phe Arg Thr Val Pro Glu Asp Asp Glu Glu 
        595                 600                 605             


Glu Lys Leu Val Ala Lys Val Arg Ala Leu Asp Leu Lys Thr Leu Tyr 
    610                 615                 620                 


Leu Thr Glu Asn Gln Glu Val Ser Thr Gly Val Lys Trp Glu Asn Tyr 
625                 630                 635                 640 


Phe Ala Ser Thr Val Asn Arg Glu Met Met Cys Ser Pro Glu Leu Lys 
                645                 650                 655     


Asn Leu Ile Arg Ala Gly Ile Pro His Glu His Arg Ser Lys Val Trp 
            660                 665                 670         


Lys Trp Cys Val Asp Arg His Thr Arg Lys Phe Lys Asp Asn Thr Glu 
        675                 680                 685             


Pro Gly His Phe Gln Thr Leu Leu Gln Lys Ala Leu Glu Lys Gln Asn 
    690                 695                 700                 


Pro Ala Ser Lys Gln Ile Glu Leu Asp Leu Leu Arg Thr Leu Pro Asn 
705                 710                 715                 720 


Asn Lys His Tyr Ser Cys Pro Thr Ser Glu Gly Ile Gln Lys Leu Arg 
                725                 730                 735     


Asn Val Leu Leu Ala Phe Ser Trp Arg Asn Pro Asp Ile Gly Tyr Cys 
            740                 745                 750         


Gln Gly Leu Asn Arg Leu Val Ala Val Ala Leu Leu Tyr Leu Glu Gln 
        755                 760                 765             


Glu Asp Ala Phe Trp Cys Leu Val Thr Ile Val Glu Val Phe Met Pro 
    770                 775                 780                 


Arg Asp Tyr Tyr Thr Lys Thr Leu Leu Gly Ser Gln Val Asp Gln Arg 
785                 790                 795                 800 


Val Phe Arg Asp Leu Met Ser Glu Lys Leu Pro Arg Leu His Gly His 
                805                 810                 815     


Phe Glu Gln Tyr Lys Val Asp Tyr Thr Leu Ile Thr Phe Asn Trp Phe 
            820                 825                 830         


Leu Val Val Phe Val Asp Ser Val Val Ser Asp Ile Leu Phe Lys Ile 
        835                 840                 845             


Trp Asp Ser Phe Leu Tyr Glu Gly Pro Lys Val Ile Phe Arg Phe Ala 
    850                 855                 860                 


Leu Ala Leu Phe Lys Tyr Lys Glu Glu Glu Ile Leu Lys Leu Gln Asp 
865                 870                 875                 880 


Ser Met Ser Ile Phe Lys Tyr Leu Arg Tyr Phe Thr Arg Thr Ile Leu 
                885                 890                 895     


Asp Ala Arg Lys Leu Ile Ser Ile Ser Phe Gly Asp Leu Asn Pro Phe 
            900                 905                 910         


Pro Leu Arg Gln Ile Arg Asn Arg Arg Ala Tyr His Leu Glu Lys Val 
        915                 920                 925             


Arg Leu Glu Leu Thr Glu Leu Glu Ala Ile Arg Glu Asp Phe Leu Arg 
    930                 935                 940                 


Glu Arg Asp Thr Ser Pro Asp Lys Gly Glu Leu Val Ser Asp Glu Glu 
945                 950                 955                 960 


Glu Asp Thr 
            


<210>  5865
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  5865

Met Ala Asp Thr Ala Thr Thr Ala Ser Ala Ala Ala Ala Ser Ala Ala 
1               5                   10                  15      


Ser Ala Ser Ser Asp Ala Pro Pro Phe Gln Leu Gly Lys Pro Arg Phe 
            20                  25                  30          


Gln Gln Thr Ser Phe Tyr Gly Arg Phe Arg His Phe Leu Asp Ile Ile 
        35                  40                  45              


Asp Pro Arg Thr Leu Phe Val Thr Glu Arg Arg Leu Arg Glu Ala Val 
    50                  55                  60                  


Gln Leu Leu Glu Asp Tyr Lys His Gly Thr Leu Arg Pro Gly Val Thr 
65                  70                  75                  80  


Asn Glu Gln Leu Trp Ser Ala Gln Lys Ile Lys Gln Ala Ile Leu His 
                85                  90                  95      


Pro Asp Thr Asn Glu Lys Ile Phe Met Pro Phe Arg Met Ser Gly Tyr 
            100                 105                 110         


Ile Pro Phe Gly Thr Pro Ile Val Val Gly Leu Leu Leu Pro Asn Gln 
        115                 120                 125             


Thr Leu Ala Ser Thr Val Phe Trp Gln Trp Leu Asn Gln Ser His Asn 
    130                 135                 140                 


Ala Cys Val Asn Tyr Ala Asn Arg Asn Ala Thr Lys Pro Ser Pro Ala 
145                 150                 155                 160 


Ser Lys Phe Ile Gln Gly Tyr Leu Gly Ala Val Ile Ser Ala Val Ser 
                165                 170                 175     


Ile Ala Val Gly Leu Asn Val Leu Val Gln Lys Ala Asn Lys Phe Thr 
            180                 185                 190         


Pro Ala Thr Arg Leu Leu Ile Gln Arg Phe Val Pro Phe Pro Ala Val 
        195                 200                 205             


Ala Ser Ala Asn Ile Cys Asn Val Val Leu Met Arg Tyr Gly Glu Leu 
    210                 215                 220                 


Glu Glu Gly Ile Asp Val Leu Asp Ser Asp Gly Asn Leu Val Gly Ser 
225                 230                 235                 240 


Ser Lys Ile Ala Ala Arg His Ala Leu Leu Glu Thr Ala Leu Thr Arg 
                245                 250                 255     


Val Val Leu Pro Met Pro Ile Leu Val Leu Pro Pro Ile Val Met Ser 
            260                 265                 270         


Met Leu Glu Lys Thr Ala Leu Leu Gln Ala Arg Pro Arg Leu Leu Leu 
        275                 280                 285             


Pro Val Gln Ser Leu Val Cys Leu Ala Ala Phe Gly Leu Ala Leu Pro 
    290                 295                 300                 


Leu Ala Ile Ser Leu Phe Pro Gln Met Ser Glu Ile Glu Thr Ser Gln 
305                 310                 315                 320 


Leu Glu Pro Glu Ile Ala Gln Ala Thr Ser Ser Arg Thr Val Val Tyr 
                325                 330                 335     


Asn Lys Gly Leu 
            340 


<210>  5866
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  5866

Met Arg Gly Ser Val Glu Cys Thr Trp Gly Trp Gly His Cys Ala Pro 
1               5                   10                  15      


Ser Pro Leu Leu Leu Trp Thr Leu Leu Leu Phe Ala Ala Pro Phe Gly 
            20                  25                  30          


Leu Leu Gly Glu Lys Thr Arg Gln Val Ser Leu Glu Val Ile Pro Asn 
        35                  40                  45              


Trp Leu Gly Pro Leu Gln Asn Leu Leu His Ile Arg Ala Val Gly Thr 
    50                  55                  60                  


Asn Ser Thr Leu His Tyr Val Trp Ser Ser Leu Gly Pro Leu Ala Val 
65                  70                  75                  80  


Val Met Val Ala Thr Asn Thr Pro His Ser Thr Leu Ser Val Asn Trp 
                85                  90                  95      


Ser Leu Leu Leu Ser Pro Glu Pro Asp Gly Gly Leu Met Val Leu Pro 
            100                 105                 110         


Lys Asp Ser Ile Gln Phe Ser Ser Ala Leu Val Phe Thr Arg Leu Leu 
        115                 120                 125             


Glu Phe Asp Ser Thr Asn Val Ser Asp Thr Ala Ala Lys Pro Leu Gly 
    130                 135                 140                 


Arg Pro Tyr Pro Pro Tyr Ser Leu Ala Asp Phe Ser Trp Asn Asn Ile 
145                 150                 155                 160 


Thr Asp Ser Leu Asp Pro Ala Thr Leu Ser Ala Thr Phe Gln Gly His 
                165                 170                 175     


Pro Met Asn Asp Pro Thr Arg Thr Phe Ala Asn Gly Ser Leu Ala Phe 
            180                 185                 190         


Arg Val Gln Ala Phe Ser Arg Ser Ser Arg Pro Ala Gln Pro Pro Arg 
        195                 200                 205             


Leu Leu His Thr Ala Asp Thr Cys Gln Leu Glu Val Ala Leu Ile Gly 
    210                 215                 220                 


Ala Ser Pro Arg Gly Asn Arg Ser Leu Phe Gly Leu Glu Val Ala Thr 
225                 230                 235                 240 


Leu Gly Gln Gly Pro Asp Cys Pro Ser Met Gln Glu Gln His Ser Ile 
                245                 250                 255     


Asp Asp Glu Tyr Ala Pro Ala Val Phe Gln Leu Asp Gln Leu Leu Trp 
            260                 265                 270         


Gly Ser Leu Pro Ser Gly Phe Ala Gln Trp Arg Pro Val Ala Tyr Ser 
        275                 280                 285             


Gln Lys Pro Gly Gly Arg Glu Ser Ala Leu Pro Cys Gln Ala Ser Pro 
    290                 295                 300                 


Leu His Pro Ala Leu Ala Tyr Ser Leu Pro Gln Ser Pro Ile Val Arg 
305                 310                 315                 320 


Ala Phe Phe Gly Ser Gln Asn Asn Phe Cys Ala Phe Asn Leu Thr Phe 
                325                 330                 335     


Gly Ala Ser Thr Gly Pro Gly Tyr Trp Asp Gln His Tyr Leu Ser Trp 
            340                 345                 350         


Ser Met Leu Leu Gly Val Gly Phe Pro Pro Val Asp Gly Leu Ser Pro 
        355                 360                 365             


Leu Val Leu Gly Ile Met Ala Val Ala Leu Gly Ala Pro Gly Leu Met 
    370                 375                 380                 


Leu Leu Gly Gly Gly Leu Val Leu Leu Leu His His Lys Lys Tyr Ser 
385                 390                 395                 400 


Glu Tyr Gln Ser Ile Asn 
                405     


<210>  5867
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  5867

Met Trp Phe Met Tyr Leu Leu Ser Trp Leu Ser Leu Phe Ile Gln Val 
1               5                   10                  15      


Ala Phe Ile Thr Leu Ala Val Ala Ala Gly Leu Tyr Tyr Leu Ala Glu 
            20                  25                  30          


Leu Ile Glu Glu Tyr Thr Val Ala Thr Ser Arg Ile Ile Lys Tyr Met 
        35                  40                  45              


Ile Trp Phe Ser Thr Ala Val Leu Ile Gly Leu Tyr Val Phe Glu Arg 
    50                  55                  60                  


Phe Pro Thr Ser Met Ile Gly Val Gly Leu Phe Thr Asn Leu Val Tyr 
65                  70                  75                  80  


Phe Gly Leu Leu Gln Thr Phe Pro Phe Ile Met Leu Thr Ser Pro Asn 
                85                  90                  95      


Phe Ile Leu Ser Cys Gly Leu Val Val Val Asn His Tyr Leu Ala Phe 
            100                 105                 110         


Gln Phe Phe Ala Glu Glu Tyr Tyr Pro Phe Ser Glu Val Leu Ala Tyr 
        115                 120                 125             


Phe Thr Phe Cys Leu Trp Ile Ile Pro Phe Ala Phe Phe Val Ser Leu 
    130                 135                 140                 


Ser Ala Gly Glu Asn Val Leu Pro Ser Thr Met Gln Pro Gly Asp Asp 
145                 150                 155                 160 


Val Val Ser Asn Tyr Phe Thr Lys Gly Lys Arg Gly Lys Arg Leu Gly 
                165                 170                 175     


Ile Leu Val Val Phe Ser Phe Ile Lys Glu Ala Ile Leu Pro Ser Arg 
            180                 185                 190         


Gln Lys Ile Tyr 
        195     


<210>  5868
<211>  553
<212>  PRT
<213>  Homo sapiens

<400>  5868

Met Ala Phe Ser Glu Leu Leu Asp Leu Val Gly Gly Leu Gly Arg Phe 
1               5                   10                  15      


Gln Val Leu Gln Thr Met Ala Leu Met Val Ser Ile Met Trp Leu Cys 
            20                  25                  30          


Thr Gln Ser Met Leu Glu Asn Phe Ser Ala Ala Val Pro Ser His Arg 
        35                  40                  45              


Cys Trp Ala Pro Leu Leu Asp Asn Ser Thr Ala Gln Ala Ser Ile Leu 
    50                  55                  60                  


Gly Ser Leu Ser Pro Glu Ala Leu Leu Ala Ile Ser Ile Pro Pro Gly 
65                  70                  75                  80  


Pro Asn Gln Arg Pro His Gln Cys Arg Arg Phe Arg Gln Pro Gln Trp 
                85                  90                  95      


Gln Leu Leu Asp Pro Asn Ala Thr Ala Thr Ser Trp Ser Glu Ala Asp 
            100                 105                 110         


Thr Glu Pro Cys Val Asp Gly Trp Val Tyr Asp Arg Ser Ile Phe Thr 
        115                 120                 125             


Ser Thr Ile Val Ala Lys Trp Asn Leu Val Cys Asp Ser His Ala Leu 
    130                 135                 140                 


Lys Pro Met Ala Gln Ser Ile Tyr Leu Ala Gly Ile Leu Val Gly Ala 
145                 150                 155                 160 


Ala Ala Cys Gly Pro Ala Ser Asp Arg Phe Gly Arg Arg Leu Val Leu 
                165                 170                 175     


Thr Trp Ser Tyr Leu Gln Met Ala Val Met Gly Thr Ala Ala Ala Phe 
            180                 185                 190         


Ala Pro Ala Phe Pro Val Tyr Cys Leu Phe Arg Phe Leu Leu Ala Phe 
        195                 200                 205             


Ala Val Ala Gly Val Met Met Asn Thr Gly Thr Leu Leu Met Glu Trp 
    210                 215                 220                 


Thr Ala Ala Arg Ala Arg Pro Leu Val Met Thr Leu Asn Ser Leu Gly 
225                 230                 235                 240 


Phe Ser Phe Gly His Gly Leu Thr Ala Ala Val Ala Tyr Gly Val Arg 
                245                 250                 255     


Asp Trp Thr Leu Leu Gln Leu Val Val Ser Val Pro Phe Phe Leu Cys 
            260                 265                 270         


Phe Leu Tyr Ser Trp Trp Leu Ala Glu Ser Ala Arg Trp Leu Leu Thr 
        275                 280                 285             


Thr Gly Arg Leu Asp Trp Gly Leu Gln Glu Leu Trp Arg Val Ala Ala 
    290                 295                 300                 


Ile Asn Gly Lys Gly Ala Val Gln Asp Thr Leu Thr Pro Glu Val Leu 
305                 310                 315                 320 


Leu Ser Ala Met Arg Glu Glu Leu Ser Met Gly Gln Pro Pro Ala Ser 
                325                 330                 335     


Leu Gly Thr Leu Leu Arg Met Pro Gly Leu Arg Phe Arg Thr Cys Ile 
            340                 345                 350         


Ser Thr Leu Cys Trp Phe Ala Phe Gly Phe Thr Phe Phe Gly Leu Ala 
        355                 360                 365             


Leu Asp Leu Gln Ala Leu Gly Ser Asn Ile Phe Leu Leu Gln Met Phe 
    370                 375                 380                 


Ile Gly Val Val Asp Ile Pro Ala Lys Met Gly Ala Leu Leu Leu Leu 
385                 390                 395                 400 


Ser His Leu Gly Arg Arg Pro Thr Leu Ala Ala Ser Leu Leu Leu Ala 
                405                 410                 415     


Gly Leu Cys Ile Leu Ala Asn Thr Leu Val Pro His Glu Met Gly Ala 
            420                 425                 430         


Leu Arg Ser Ala Leu Ala Val Leu Gly Leu Gly Gly Val Gly Ala Ala 
        435                 440                 445             


Phe Thr Cys Ile Thr Ile Tyr Ser Ser Glu Leu Phe Pro Thr Val Leu 
    450                 455                 460                 


Arg Met Thr Ala Val Gly Leu Gly Gln Met Ala Ala Arg Gly Gly Ala 
465                 470                 475                 480 


Ile Leu Gly Pro Leu Val Arg Leu Leu Gly Val His Gly Pro Trp Leu 
                485                 490                 495     


Pro Leu Leu Val Tyr Gly Thr Val Pro Val Leu Ser Gly Leu Ala Ala 
            500                 505                 510         


Leu Leu Leu Pro Glu Thr Gln Ser Leu Pro Leu Pro Asp Thr Ile Gln 
        515                 520                 525             


Asp Val Gln Asn Gln Ala Val Lys Lys Ala Thr His Gly Thr Leu Gly 
    530                 535                 540                 


Asn Ser Val Leu Lys Ser Thr Gln Phe 
545                 550             


<210>  5869
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  5869

Met Trp Val Leu Gly Ile Ala Ala Thr Phe Cys Gly Leu Phe Leu Leu 
1               5                   10                  15      


Pro Gly Phe Ala Leu Gln Ile Gln Cys Tyr Gln Cys Glu Glu Phe Gln 
            20                  25                  30          


Leu Asn Asn Asp Cys Ser Ser Pro Glu Phe Ile Val Asn Cys Thr Val 
        35                  40                  45              


Asn Val Gln Asp Met Cys Gln Lys Glu Val Met Glu Gln Ser Ala Gly 
    50                  55                  60                  


Ile Met Tyr Arg Lys Ser Cys Ala Ser Ser Ala Ala Cys Leu Ile Ala 
65                  70                  75                  80  


Ser Ala Gly Tyr Gln Ser Phe Cys Ser Pro Gly Lys Leu Asn Ser Val 
                85                  90                  95      


Cys Ile Ser Cys Cys Asn Thr Pro Leu Cys Asn Gly Pro Arg Pro Lys 
            100                 105                 110         


Lys Arg Gly Ser Ser Ala Ser Ala Leu Arg Pro Gly Leu Arg Thr Thr 
        115                 120                 125             


Ile Leu Phe Leu Lys Leu Ala Leu Phe Ser Ala His Cys 
    130                 135                 140     


<210>  5870
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  5870

Met Gln Thr Ser Glu Arg Glu Gly Ser Gly Pro Glu Leu Ser Pro Ser 
1               5                   10                  15      


Val Met Pro Glu Ala Pro Leu Glu Ser Pro Pro Phe Pro Thr Lys Ser 
            20                  25                  30          


Pro Ala Phe Asp Leu Phe Asn Leu Val Leu Ser Tyr Lys Arg Leu Glu 
        35                  40                  45              


Ile Tyr Leu Glu Pro Leu Lys Asp Ala Gly Asp Gly Val Arg Tyr Leu 
    50                  55                  60                  


Leu Arg Trp Gln Met Pro Leu Cys Ser Leu Leu Thr Cys Leu Gly Leu 
65                  70                  75                  80  


Asn Val Leu Phe Leu Thr Leu Asn Glu Gly Ala Trp Tyr Ser Val Gly 
                85                  90                  95      


Ala Leu Met Ile Ser Val Pro Ala Leu Leu Gly Tyr Leu Gln Glu Val 
            100                 105                 110         


Cys Arg Ala Arg Leu Pro Asp Ser Glu Leu Met Arg Arg Lys Tyr His 
        115                 120                 125             


Ser Val Arg Gln Glu Asp Leu Gln Arg Gly Arg Leu Ser Arg Pro Glu 
    130                 135                 140                 


Ala Val Ala Glu Val Lys Ser Phe Leu Ile Gln Leu Glu Ala Phe Leu 
145                 150                 155                 160 


Ser Arg Leu Cys Cys Thr Cys Glu Ala Ala Tyr Arg Val Leu His Trp 
                165                 170                 175     


Glu Asn Pro Val Val Ser Ser Gln Phe Tyr Gly Ala Leu Leu Gly Thr 
            180                 185                 190         


Val Cys Met Leu Tyr Leu Leu Pro Leu Cys Trp Val Leu Thr Leu Leu 
        195                 200                 205             


Asn Ser Thr Leu Phe Leu Gly Asn Val Glu Phe Phe Arg Val Val Ser 
    210                 215                 220                 


Glu Tyr Arg Ala Ser Leu Gln Gln Arg Met Asn Pro Lys Gln Glu Glu 
225                 230                 235                 240 


His Ala Phe Glu Ser Pro Pro Pro Pro Asp Val Gly Gly Lys Asp Gly 
                245                 250                 255     


Leu Met Asp Ser Thr Pro Ala Leu Thr Pro Thr Glu Asp Leu Thr Pro 
            260                 265                 270         


Gly Ser Val Glu Glu Ala Glu Glu Ala Glu Pro Asp Glu Glu Phe Lys 
        275                 280                 285             


Asp Ala Ile Glu Glu Thr His Leu Val Val Leu Glu Asp Asp Glu Gly 
    290                 295                 300                 


Ala Pro Cys Pro Ala Glu Asp Glu Leu Ala Leu Gln Asp Asn Gly Phe 
305                 310                 315                 320 


Leu Ser Lys Asn Glu Val Leu Arg Ser Lys Val Ser Arg Leu Thr Glu 
                325                 330                 335     


Arg Leu Arg Lys Arg Tyr Pro Thr Asn Asn Phe Gly Asn Cys Thr Gly 
            340                 345                 350         


Cys Ser Ala Thr Phe Ser Val Leu Lys Lys Arg Arg Ser Cys Ser Asn 
        355                 360                 365             


Cys Gly Asn Ser Phe Cys Ser Arg Cys Cys Ser Phe Lys Val Pro Lys 
    370                 375                 380                 


Ser Ser Met Gly Ala Thr Ala Pro Glu Ala Gln Arg Glu Thr Val Phe 
385                 390                 395                 400 


Val Cys Ala Ser Cys Asn Gln Thr Leu Ser Lys 
                405                 410     


<210>  5871
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  5871

Met Thr Gln Pro Val Pro Arg Leu Ser Val Pro Ala Ala Leu Ala Leu 
1               5                   10                  15      


Gly Ser Ala Ala Leu Gly Ala Ala Phe Ala Thr Gly Leu Phe Leu Gly 
            20                  25                  30          


Arg Arg Cys Pro Pro Trp Arg Gly Arg Arg Glu Gln Cys Leu Leu Pro 
        35                  40                  45              


Pro Glu Asp Ser Arg Leu Trp Gln Tyr Leu Leu Ser Arg Ser Met Arg 
    50                  55                  60                  


Glu His Pro Ala Leu Arg Ser Leu Arg Leu Leu Thr Leu Glu Gln Pro 
65                  70                  75                  80  


Gln Gly Asp Ser Met Met Thr Cys Glu Gln Ala Gln Leu Leu Ala Asn 
                85                  90                  95      


Leu Ala Arg Leu Ile Gln Ala Lys Lys Ala Leu Asp Leu Gly Thr Phe 
            100                 105                 110         


Thr Gly Tyr Ser Ala Leu Ala Leu Ala Leu Ala Leu Pro Ala Asp Gly 
        115                 120                 125             


Arg Val Val Thr Cys Glu Val Asp Ala Gln Pro Pro Glu Leu Gly Arg 
    130                 135                 140                 


Pro Leu Trp Arg Gln Ala Glu Ala Glu His Lys Ile Asp Leu Arg Leu 
145                 150                 155                 160 


Lys Pro Ala Leu Glu Thr Leu Asp Glu Leu Leu Ala Ala Gly Glu Ala 
                165                 170                 175     


Gly Thr Phe Asp Val Ala Val Val Asp Ala Asp Lys Glu Asn Cys Ser 
            180                 185                 190         


Ala Tyr Tyr Glu Arg Cys Leu Gln Leu Leu Arg Pro Gly Gly Ile Leu 
        195                 200                 205             


Ala Val Leu Arg Val Leu Trp Arg Gly Lys Val Leu Gln Pro Pro Lys 
    210                 215                 220                 


Gly Asp Val Ala Ala Glu Cys Val Arg Asn Leu Asn Glu Arg Ile Arg 
225                 230                 235                 240 


Arg Asp Val Arg Val Tyr Ile Ser Leu Leu Pro Leu Gly Asp Gly Leu 
                245                 250                 255     


Thr Leu Ala Phe Lys Ile 
            260         


<210>  5872
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  5872

Met Gly Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Gly Glu Gly Ala Arg Ser Pro Ser Pro Ala Ala Val Ser Leu Gly Leu 
            20                  25                  30          


Gly Val Ala Val Val Ser Ser Leu Val Asn Gly Ser Thr Phe Val Leu 
        35                  40                  45              


Gln Lys Lys Gly Ile Val Arg Ala Lys Arg Arg Gly Thr Ser Tyr Leu 
    50                  55                  60                  


Thr Asp Ile Val Trp Trp Ala Gly Thr Ile Ala Met Ala Val Gly Gln 
65                  70                  75                  80  


Ile Gly Asn Phe Leu Ala Tyr Thr Ala Val Pro Thr Val Leu Val Thr 
                85                  90                  95      


Pro Leu Gly Ala Leu Gly Val Pro Phe Gly Ser Ile Leu Ala Ser Tyr 
            100                 105                 110         


Leu Leu Lys Glu Lys Leu Asn Ile Leu Gly Lys Leu Gly Cys Leu Leu 
        115                 120                 125             


Ser Cys Ala Gly Ser Val Val Leu Ile Ile His Ser Pro Lys Ser Glu 
    130                 135                 140                 


Ser Val Thr Thr Gln Ala Glu Leu Glu Glu Lys Leu Thr Asn Pro Val 
145                 150                 155                 160 


Phe Val Gly Tyr Leu Cys Ile Val Leu Leu Met Leu Leu Leu Leu Ile 
                165                 170                 175     


Phe Trp Ile Ala Pro Ala His Gly Pro Thr Asn Ile Met Val Tyr Ile 
            180                 185                 190         


Ser Ile Cys Ser Leu Leu Gly Ser Phe Thr Val Pro Ser Thr Lys Gly 
        195                 200                 205             


Ile Gly Leu Ala Ala Gln Asp Ile Leu His Asn Asn Pro Ser Ser Gln 
    210                 215                 220                 


Arg Ala Leu Cys Leu Cys Leu Val Leu Leu Ala Val Leu Gly Cys Ser 
225                 230                 235                 240 


Ile Ile Val Gln Phe Arg Tyr Ile Asn Lys Ala Leu Glu Cys Phe Asp 
                245                 250                 255     


Ser Ser Val Phe Gly Ala Ile Tyr Tyr Val Val Phe Thr Thr Leu Val 
            260                 265                 270         


Leu Leu Ala Ser Ala Ile Leu Phe Arg Glu Trp Ser Asn Val Gly Leu 
        275                 280                 285             


Val Asp Phe Leu Gly Met Ala Cys Gly Phe Thr Thr Val Ser Val Gly 
    290                 295                 300                 


Ile Val Leu Ile Gln Val Phe Lys Glu Phe Asn Phe Asn Leu Gly Glu 
305                 310                 315                 320 


Met Asn Lys Ser Asn Met Lys Thr Asp 
                325                 


<210>  5873
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  5873

Met Trp Pro Pro Asp Pro Asp Pro Asp Pro Asp Pro Glu Pro Ala Gly 
1               5                   10                  15      


Gly Ser Arg Pro Gly Pro Ala Val Pro Gly Leu Arg Ala Leu Leu Pro 
            20                  25                  30          


Ala Arg Ala Phe Leu Cys Ser Leu Lys Gly Arg Leu Leu Leu Ala Glu 
        35                  40                  45              


Ser Gly Leu Ser Phe Ile Thr Phe Ile Cys Tyr Val Ala Ser Ser Ala 
    50                  55                  60                  


Ser Ala Phe Leu Thr Ala Pro Leu Leu Glu Phe Leu Leu Ala Leu Tyr 
65                  70                  75                  80  


Phe Leu Phe Ala Asp Ala Met Gln Leu Asn Asp Lys Trp Gln Gly Leu 
                85                  90                  95      


Cys Trp Pro Met Met Asp Phe Leu Arg Cys Val Thr Ala Ala Leu Ile 
            100                 105                 110         


Tyr Phe Ala Ile Ser Ile Thr Ala Ile Ala Lys Tyr Ser Asp Gly Ala 
        115                 120                 125             


Ser Lys Ala Ala Gly Val Phe Gly Phe Phe Ala Thr Ile Val Phe Ala 
    130                 135                 140                 


Thr Asp Phe Tyr Leu Ile Phe Asn Asp Val Ala Lys Phe Leu Lys Gln 
145                 150                 155                 160 


Gly Asp Ser Ala Asp Glu Thr Thr Ala His Lys Thr Glu Glu Glu Asn 
                165                 170                 175     


Ser Asp Ser Asp Ser Asp 
            180         


<210>  5874
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  5874

Met Leu Arg Cys Gly Gly Arg Gly Leu Leu Leu Gly Leu Ala Val Ala 
1               5                   10                  15      


Ala Ala Ala Val Met Ala Ala Arg Leu Met Gly Trp Trp Gly Pro Arg 
            20                  25                  30          


Ala Gly Phe Arg Leu Phe Ile Pro Glu Glu Leu Ser Arg Tyr Arg Gly 
        35                  40                  45              


Gly Pro Gly Asp Pro Gly Leu Tyr Leu Ala Leu Leu Gly Arg Val Tyr 
    50                  55                  60                  


Asp Val Ser Ser Gly Arg Arg His Tyr Glu Pro Gly Ser His Tyr Ser 
65                  70                  75                  80  


Gly Phe Ala Gly Arg Asp Ala Ser Arg Ala Phe Val Thr Gly Asp Cys 
                85                  90                  95      


Ser Glu Ala Gly Leu Val Asp Asp Val Ser Asp Leu Ser Ala Ala Glu 
            100                 105                 110         


Met Leu Thr Leu His Asn Trp Leu Ser Phe Tyr Glu Lys Asn Tyr Val 
        115                 120                 125             


Cys Val Gly Arg Val Thr Gly Arg Phe Tyr Gly Glu Asp Gly Leu Pro 
    130                 135                 140                 


Thr Pro Ala Leu Thr Gln Val Glu Ala Ala Ile Thr Arg Gly Leu Glu 
145                 150                 155                 160 


Ala Asn Lys Leu Gln Leu Gln Glu Lys Gln Thr Phe Pro Pro Cys Asn 
                165                 170                 175     


Ala Glu Trp Ser Ser Ala Arg Gly Ser Arg Leu Trp Cys Ser Gln Lys 
            180                 185                 190         


Ser Gly Gly Val Ser Arg Asp Trp Ile Gly Val Pro Arg Lys Leu Tyr 
        195                 200                 205             


Lys Pro Gly Ala Lys Glu Pro Arg Cys Val Cys Val Arg Thr Thr Gly 
    210                 215                 220                 


Pro Pro Ser Gly Gln Met Pro Asp Asn Pro Pro His Arg Asn Arg Gly 
225                 230                 235                 240 


Asp Leu Asp His Pro Asn Leu Ala Glu Tyr Thr Gly Cys Pro Pro Leu 
                245                 250                 255     


Ala Ile Thr Cys Ser Phe Pro Leu 
            260                 


<210>  5875
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  5875

Met Gly Ser Pro Gly Met Val Leu Gly Leu Leu Val Gln Ile Trp Ala 
1               5                   10                  15      


Leu Gln Glu Ala Ser Ser Leu Ser Val Gln Gln Gly Pro Asn Leu Leu 
            20                  25                  30          


Gln Val Arg Gln Gly Ser Gln Ala Thr Leu Val Cys Gln Val Asp Gln 
        35                  40                  45              


Ala Thr Ala Trp Glu Arg Leu Arg Val Lys Trp Thr Lys Asp Gly Ala 
    50                  55                  60                  


Ile Leu Cys Gln Pro Tyr Ile Thr Asn Gly Ser Leu Ser Leu Gly Val 
65                  70                  75                  80  


Cys Gly Pro Gln Gly Arg Leu Ser Trp Gln Ala Pro Ser His Leu Thr 
                85                  90                  95      


Leu Gln Leu Asp Pro Val Ser Leu Asn His Ser Gly Ala Tyr Val Cys 
            100                 105                 110         


Trp Ala Ala Val Glu Ile Pro Glu Leu Glu Glu Ala Glu Gly Asn Ile 
        115                 120                 125             


Thr Arg Leu Phe Val Asp Pro Asp Asp Pro Thr Gln Asn Arg Asn Arg 
    130                 135                 140                 


Ile Ala Ser Phe Pro Gly Phe Leu Phe Val Leu Leu Gly Val Gly Ser 
145                 150                 155                 160 


Met Gly Val Ala Ala Ile Val Trp Gly Ala Trp Phe Trp Gly Arg Arg 
                165                 170                 175     


Ser Cys Gln Gln Arg Asp Ser Gly Asn Ser Pro Gly Asn Ala Phe Tyr 
            180                 185                 190         


Ser Asn Val Leu Tyr Arg Pro Arg Gly Ala Pro Lys Lys Ser Glu Asp 
        195                 200                 205             


Cys Ser Gly Glu Gly Lys Asp Gln Arg Gly Gln Ser Ile Tyr Ser Thr 
    210                 215                 220                 


Ser Phe Pro Gln Pro Ala Pro Arg Gln Pro His Leu Ala Ser Arg Pro 
225                 230                 235                 240 


Cys Pro Ser Pro Arg Pro Cys Pro Ser Pro Arg Pro Gly His Pro Val 
                245                 250                 255     


Ser Met Val Arg Val Ser Pro Arg Pro Ser Pro Thr Gln Gln Pro Arg 
            260                 265                 270         


Pro Lys Gly Phe Pro Lys Val Gly Glu Glu 
        275                 280         


<210>  5876
<211>  773
<212>  PRT
<213>  Homo sapiens

<400>  5876

Met Pro Lys Val Met Lys Asp Val Val His Pro Leu Gly Gly Glu Glu 
1               5                   10                  15      


Pro Ser Met Ala Arg Ala Val Val Arg Ser Val Gly Gly Phe Thr Leu 
            20                  25                  30          


Gly Leu Ser Leu Ala Thr Ala Tyr Gly Leu Leu Glu Leu Leu Val Glu 
        35                  40                  45              


Gly His Ser Pro Trp Gly Cys Leu Val Gly Thr Leu Thr Leu Ala Ala 
    50                  55                  60                  


Phe Leu Ser Leu Gly Met Gly Phe Ser Arg Gln Val Arg Ala Thr Val 
65                  70                  75                  80  


Leu Leu Leu Leu Pro Gln Ala Phe Ser Arg Gln Gly Arg Thr Leu Leu 
                85                  90                  95      


Leu Val Ala Ala Phe Gly Leu Val Leu Gln Gly Pro Cys Ala Asn Thr 
            100                 105                 110         


Leu Arg Asn Phe Thr Arg Ala Ser Glu Ala Val Ala Cys Gly Ala Glu 
        115                 120                 125             


Leu Ala Leu Asn Gln Thr Ala Glu Val Leu Gln Arg Ala Lys Gln Pro 
    130                 135                 140                 


Leu Val Ser Ala Leu Asn Lys Ile Lys Ala Ile Ala Arg Lys Thr Lys 
145                 150                 155                 160 


Glu Val Ala Asp Arg Val Arg Lys Phe Phe Arg Ser Ile Met Asp Gly 
                165                 170                 175     


Val Lys His Ile Ala Arg Ala Leu Arg Asn Val Trp Gln Trp Leu Leu 
            180                 185                 190         


His Ile Gly Asp Val Cys Asn Ser Glu Leu Gly Asn Pro Tyr Leu Lys 
        195                 200                 205             


Cys Ala Arg Val Phe Asp Asp Ala Lys Asp Ser Cys Met Met Val Ile 
    210                 215                 220                 


Pro Gln Ala Tyr His Leu Cys Tyr Val Leu Met Pro Phe Lys Leu Ala 
225                 230                 235                 240 


Leu Cys Gly Leu Ala Ser Leu Val Gln Val Phe Cys Val Ile Pro Lys 
                245                 250                 255     


Tyr Ile Gln Pro Phe Leu Arg Gln Thr Ile Gly Thr Pro Val Ile Gln 
            260                 265                 270         


Leu Leu Asn Arg Val Arg Gln Glu Phe Glu Phe Asn Met Thr Ala Thr 
        275                 280                 285             


His His Phe Ser Val Asp Leu Asn Ala Ser Arg Ser Leu Ser Gln Val 
    290                 295                 300                 


Ala Met Asp Leu His Glu Ala Val Ser Met Lys Leu His Arg Val Arg 
305                 310                 315                 320 


Glu Ala Leu Ala Leu Met Gly Phe Thr Thr Pro Leu Leu Leu Val Leu 
                325                 330                 335     


Leu Tyr Leu Gln Ala Leu Phe Tyr Arg Tyr Cys Tyr Leu Asn Trp Asp 
            340                 345                 350         


His Tyr Asp Asn Ile Tyr Ile Thr Ser Arg Phe Leu Arg Met Glu Ala 
        355                 360                 365             


Val Arg Ser Thr Ala Gly Leu Pro Thr Val Leu Pro Leu Ser Ala His 
    370                 375                 380                 


Glu Ala Arg Arg Tyr Ile Pro Pro Gly Ser Ile Phe Leu Ser Gln Trp 
385                 390                 395                 400 


Glu Lys Phe Phe Tyr Ile Leu Glu Thr Phe Asn Leu Ile Arg His Leu 
                405                 410                 415     


Leu Leu Val Leu Phe Leu Val Phe Leu Asp Tyr Ala Val Phe Trp Val 
            420                 425                 430         


Leu Asp Leu Ala Arg His Gln Leu Gln Gly Glu Ile Val Ala Arg Ser 
        435                 440                 445             


Pro Val Leu Val Ser Leu Thr Val Glu Gly Thr Gly Tyr Ala Gly Asn 
    450                 455                 460                 


Ile Tyr Arg Asp Leu Val Ser Ala Phe Asp Val Leu Gln Gln Gly Asn 
465                 470                 475                 480 


Ile Ser Ile Leu Ser Arg Arg Cys Leu Leu Arg Pro Ser Glu Pro Asp 
                485                 490                 495     


Ser Thr Gly Tyr Ile Val Ile Gly Val Met Tyr Gly Leu Cys Phe Phe 
            500                 505                 510         


Ile Thr Leu Phe Gly Ser Tyr Val Ser Arg Leu Arg Arg Val Ile Cys 
        515                 520                 525             


Ala Ser Tyr Tyr Pro Ser Arg Glu Gln Glu Arg Ile Ser Tyr Leu Tyr 
    530                 535                 540                 


Asn Val Leu Leu Ser Arg Arg Thr Asn Leu Leu Ala Ala Leu His Arg 
545                 550                 555                 560 


Ser Val Arg Arg Arg Ala Ala Asp Gln Gly His Arg Ser Ala Phe Leu 
                565                 570                 575     


Val Leu Ala Ser Arg Cys Pro Cys Leu Gly Pro Phe Val Ser His Phe 
            580                 585                 590         


Trp Leu His Gln Ala Tyr Cys Leu Gly Cys Gly Gln Pro Gln Asp Glu 
        595                 600                 605             


Gly Asp Met Glu Asn Thr Val Ser Cys Ser Thr Pro Gly Cys Gln Gly 
    610                 615                 620                 


Leu Tyr Cys Leu Thr Cys Phe Arg Leu Leu Asp Asn Thr Cys Ser Val 
625                 630                 635                 640 


Cys Ala Ser Pro Leu Ser Tyr Gln Gly Asp Leu Asp Leu Glu Leu Asp 
                645                 650                 655     


Ser Ser Asp Glu Glu Gly Pro Gln Leu Trp Leu Ala Ala Ala Gln Arg 
            660                 665                 670         


Lys Asp Pro Glu Gln Ala Trp Leu Leu Gln Gln Gln Leu Gln Glu Val 
        675                 680                 685             


Leu Gly Arg Ser Leu Ser Met Glu Ser Thr Ser Glu Ser Ser Asp Leu 
    690                 695                 700                 


Asp Glu Glu Lys Gly Pro Gln Gln Arg Lys His Gly Gln Gln Pro Leu 
705                 710                 715                 720 


Pro Glu Ala His Gln Pro Val Ser Ile Leu Thr Ser Pro Glu Pro His 
                725                 730                 735     


Arg Pro Pro Glu Thr Ser Ser Ala Thr Lys Gly Ala Pro Thr Pro Ala 
            740                 745                 750         


Ser Glu Pro Ser Val Pro Leu Ser Pro Pro Ser Leu Pro Asp Pro Ser 
        755                 760                 765             


His Pro Pro Pro Lys 
    770             


<210>  5877
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  5877

Met Ser Glu Gln Glu Ala Gln Ala Pro Gly Gly Arg Gly Leu Pro Pro 
1               5                   10                  15      


Asp Met Leu Ala Glu Gln Val Glu Leu Trp Trp Ser Gln Gln Pro Arg 
            20                  25                  30          


Arg Ser Ala Leu Cys Phe Val Val Ala Val Gly Leu Val Ala Gly Cys 
        35                  40                  45              


Gly Ala Gly Gly Val Ala Leu Leu Ser Thr Thr Ser Ser Arg Ser Gly 
    50                  55                  60                  


Glu Trp Arg Leu Ala Thr Gly Thr Val Leu Cys Leu Leu Ala Leu Leu 
65                  70                  75                  80  


Val Leu Val Lys Gln Leu Met Ser Ser Ala Val Gln Asp Met Asn Cys 
                85                  90                  95      


Ile Arg Gln Ala His His Val Ala Leu Leu Arg Ser Gly Gly Gly Ala 
            100                 105                 110         


Asp Ala Leu Val Val Leu Leu Ser Gly Leu Val Leu Leu Val Thr Gly 
        115                 120                 125             


Leu Thr Leu Ala Gly Leu Ala Ala Ala Pro Ala Pro Ala Arg Pro Leu 
    130                 135                 140                 


Ala Ala Met Leu Ser Val Gly Ile Ala Leu Ala Ala Leu Gly Ser Leu 
145                 150                 155                 160 


Leu Leu Leu Gly Leu Leu Leu Tyr Gln Val Gly Val Ser Gly His Cys 
                165                 170                 175     


Pro Ser Ile Cys Met Ala Thr Pro Ser Thr His Ser Gly His Gly Gly 
            180                 185                 190         


His Gly Ser Ile Phe Ser Ile Ser Gly Gln Leu Ser Ala Gly Arg Arg 
        195                 200                 205             


His Glu Thr Thr Ser Ser Ile Ala Ser Leu Ile 
    210                 215                 


<210>  5878
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  5878

Met Ala Leu Arg Ser Ala Gln Gly Asp Gly Pro Thr Ser Gly His Trp 
1               5                   10                  15      


Asp Gly Gly Ala Glu Lys Ala Asp Phe Asn Ala Lys Arg Lys Lys Lys 
            20                  25                  30          


Val Ala Glu Ile His Gln Ala Leu Asn Ser Asp Pro Thr Asp Val Ala 
        35                  40                  45              


Ala Leu Arg Arg Met Ala Ile Ser Glu Gly Gly Leu Leu Thr Asp Glu 
    50                  55                  60                  


Ile Arg Arg Lys Val Trp Pro Lys Leu Leu Asn Val Asn Ala Asn Asp 
65                  70                  75                  80  


Pro Pro Pro Ile Ser Gly Lys Asn Leu Arg Gln Met Ser Lys Asp Tyr 
                85                  90                  95      


Gln Gln Val Leu Leu Asp Val Arg Arg Ser Leu Arg Arg Phe Pro Pro 
            100                 105                 110         


Gly Met Pro Glu Glu Gln Arg Glu Gly Leu Gln Glu Glu Leu Ile Asp 
        115                 120                 125             


Ile Ile Leu Leu Ile Leu Glu Arg Asn Pro Gln Leu His Tyr Tyr Gln 
    130                 135                 140                 


Gly Tyr His Asp Ile Val Val Thr Phe Leu Leu Val Val Gly Glu Arg 
145                 150                 155                 160 


Leu Ala Thr Ser Leu Val Glu Lys Leu Ser Thr His His Leu Arg Asp 
                165                 170                 175     


Phe Met Asp Pro Thr Met Asp Asn Thr Lys His Ile Leu Asn Tyr Leu 
            180                 185                 190         


Met Pro Ile Ile Asp Gln Val Asn Pro Glu Leu His Asp Phe Met Gln 
        195                 200                 205             


Ser Ala Glu Val Gly Thr Ile Phe Ala Leu Ser Trp Leu Ile Thr Trp 
    210                 215                 220                 


Phe Gly His Val Leu Ser Asp Phe Arg His Val Val Arg Leu Tyr Asp 
225                 230                 235                 240 


Phe Phe Leu Ala Cys His Pro Leu Met Pro Ile Tyr Phe Ala Ala Val 
                245                 250                 255     


Ile Val Leu Tyr Arg Glu Gln Glu Val Leu Asp Cys Asp Cys Asp Met 
            260                 265                 270         


Ala Ser Val His His Leu Leu Ser Gln Ile Pro Gln Asp Leu Pro Tyr 
        275                 280                 285             


Glu Thr Leu Ile Ser Arg Ala Gly Asp Leu Phe Val Gln Phe Pro Pro 
    290                 295                 300                 


Ser Glu Leu Ala Arg Glu Ala Ala Ala Gln Gln Gln Ala Glu Arg Thr 
305                 310                 315                 320 


Ala Ala Ser Thr Phe Lys Asp Phe Glu Leu Ala Ser Ala Gln Gln Arg 
                325                 330                 335     


Pro Asp Met Val Leu Arg Gln Arg Phe Arg Gly Leu Leu Arg Pro Glu 
            340                 345                 350         


Asp Arg Thr Lys Asp Val Leu Thr Lys Pro Arg Thr Asn Arg Phe Val 
        355                 360                 365             


Lys Leu Ala Val Met Gly Leu Thr Val Ala Leu Gly Ala Ala Ala Leu 
    370                 375                 380                 


Ala Val Val Lys Ser Ala Leu Glu Trp Ala Pro Lys Phe Gln Leu Gln 
385                 390                 395                 400 


Leu Phe Pro 
            


<210>  5879
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  5879

Met Arg Leu Asn Ile Ala Ile Phe Phe Gly Ala Leu Phe Gly Ala Leu 
1               5                   10                  15      


Gly Val Leu Leu Phe Leu Val Ala Phe Gly Ser Asp Tyr Trp Leu Leu 
            20                  25                  30          


Ala Thr Glu Val Gly Arg Cys Ser Gly Glu Lys Asn Ile Glu Asn Val 
        35                  40                  45              


Thr Phe His His Glu Gly Phe Phe Trp Arg Cys Trp Phe Asn Gly Ile 
    50                  55                  60                  


Val Glu Glu Asn Asp Ser Asn Ile Trp Lys Phe Trp Tyr Thr Asn Gln 
65                  70                  75                  80  


Pro Pro Ser Lys Asn Cys Thr His Ala Tyr Leu Ser Pro Tyr Pro Phe 
                85                  90                  95      


Met Arg Gly Glu His Asn Ser Thr Ser Tyr Asp Ser Ala Val Ile Tyr 
            100                 105                 110         


Arg Gly Phe Trp Ala Val Leu Met Leu Leu Gly Val Val Ala Val Val 
        115                 120                 125             


Ile Ala Ser Phe Leu Ile Ile Cys Ala Ala Pro Phe Ala Ser His Phe 
    130                 135                 140                 


Leu Tyr Lys Ala Gly Gly Gly Ser Tyr Ile Ala Ala Gly Ile Leu Phe 
145                 150                 155                 160 


Ser Leu Val Val Met Leu Tyr Val Ile Trp Val Gln Ala Val Ala Asp 
                165                 170                 175     


Met Glu Ser Tyr Arg Asn Met Lys Met Lys Asp Cys Leu Asp Phe Thr 
            180                 185                 190         


Pro Ser Val Leu Tyr Gly Trp Ser Phe Phe Leu Ala Pro Ala Gly Ile 
        195                 200                 205             


Phe Phe Ser Leu Leu Ala Gly Leu Leu Phe Leu Val Val Gly Arg His 
    210                 215                 220                 


Ile Gln Ile His His 
225                 


<210>  5880
<211>  1107
<212>  PRT
<213>  Homo sapiens

<400>  5880

Met Pro Val Met Lys Gly Leu Leu Ala Pro Gln Asn Thr Phe Leu Asp 
1               5                   10                  15      


Thr Ile Ala Thr Arg Phe Asp Gly Thr His Ser Asn Phe Ile Leu Ala 
            20                  25                  30          


Asn Ala Gln Val Ala Lys Gly Phe Pro Ile Val Tyr Cys Ser Asp Gly 
        35                  40                  45              


Phe Cys Glu Leu Ala Gly Phe Ala Arg Thr Glu Val Met Gln Lys Ser 
    50                  55                  60                  


Cys Ser Cys Lys Phe Leu Phe Gly Val Glu Thr Asn Glu Gln Leu Met 
65                  70                  75                  80  


Leu Gln Ile Glu Lys Ser Leu Glu Glu Lys Thr Glu Phe Lys Gly Glu 
                85                  90                  95      


Ile Met Phe Tyr Lys Lys Asn Gly Ser Pro Phe Trp Cys Leu Leu Asp 
            100                 105                 110         


Ile Val Pro Ile Lys Asn Glu Lys Gly Asp Val Val Leu Phe Leu Ala 
        115                 120                 125             


Ser Phe Lys Asp Ile Thr Asp Thr Lys Val Lys Ile Thr Pro Glu Asp 
    130                 135                 140                 


Lys Lys Glu Asp Lys Val Lys Gly Arg Ser Arg Ala Gly Thr His Phe 
145                 150                 155                 160 


Asp Ser Ala Arg Arg Arg Ser Arg Ala Val Leu Tyr His Ile Ser Gly 
                165                 170                 175     


His Leu Gln Arg Arg Glu Lys Asn Lys Leu Lys Ile Asn Asn Asn Val 
            180                 185                 190         


Phe Val Asp Lys Pro Ala Phe Pro Glu Tyr Lys Val Ser Asp Ala Lys 
        195                 200                 205             


Lys Ser Lys Phe Ile Leu Leu His Phe Ser Thr Phe Lys Ala Gly Trp 
    210                 215                 220                 


Asp Trp Leu Ile Leu Leu Ala Thr Phe Tyr Val Ala Val Thr Val Pro 
225                 230                 235                 240 


Tyr Asn Val Cys Phe Ile Gly Asn Asp Asp Leu Ser Thr Thr Arg Ser 
                245                 250                 255     


Thr Thr Val Ser Asp Ile Ala Val Glu Ile Leu Phe Ile Ile Asp Ile 
            260                 265                 270         


Ile Leu Asn Phe Arg Thr Thr Tyr Val Ser Lys Ser Gly Gln Val Ile 
        275                 280                 285             


Phe Glu Ala Arg Ser Ile Cys Ile His Tyr Val Thr Thr Trp Phe Ile 
    290                 295                 300                 


Ile Asp Leu Ile Ala Ala Leu Pro Phe Asp Leu Leu Tyr Ala Phe Asn 
305                 310                 315                 320 


Val Thr Val Val Ser Leu Val His Leu Leu Lys Thr Val Arg Leu Leu 
                325                 330                 335     


Arg Leu Leu Arg Leu Leu Gln Lys Leu Asp Arg Tyr Ser Gln His Ser 
            340                 345                 350         


Thr Ile Val Leu Thr Leu Leu Met Ser Met Phe Ala Leu Leu Ala His 
        355                 360                 365             


Trp Met Ala Cys Ile Trp Tyr Val Ile Gly Lys Met Glu Arg Glu Asp 
    370                 375                 380                 


Asn Ser Leu Leu Lys Trp Glu Val Gly Trp Leu His Glu Leu Gly Lys 
385                 390                 395                 400 


Arg Leu Glu Ser Pro Tyr Tyr Gly Asn Asn Thr Leu Gly Gly Pro Ser 
                405                 410                 415     


Ile Arg Ser Ala Tyr Ile Ala Ala Leu Tyr Phe Thr Leu Ser Ser Leu 
            420                 425                 430         


Thr Ser Val Gly Phe Gly Asn Val Ser Ala Asn Thr Asp Ala Glu Lys 
        435                 440                 445             


Ile Phe Ser Ile Cys Thr Met Leu Ile Gly Ala Leu Met His Ala Leu 
    450                 455                 460                 


Val Phe Gly Asn Val Thr Ala Ile Ile Gln Arg Met Tyr Ser Arg Trp 
465                 470                 475                 480 


Ser Leu Tyr His Thr Arg Thr Lys Asp Leu Lys Asp Phe Ile Arg Val 
                485                 490                 495     


His His Leu Pro Gln Gln Leu Lys Gln Arg Met Leu Glu Tyr Phe Gln 
            500                 505                 510         


Thr Thr Trp Ser Val Asn Asn Gly Ile Asp Ser Asn Glu Leu Leu Lys 
        515                 520                 525             


Asp Phe Pro Asp Glu Leu Arg Ser Asp Ile Thr Met His Leu Asn Lys 
    530                 535                 540                 


Glu Ile Leu Gln Leu Ser Leu Phe Glu Cys Ala Ser Arg Gly Cys Leu 
545                 550                 555                 560 


Arg Ser Leu Ser Leu His Ile Lys Thr Ser Phe Cys Ala Pro Gly Glu 
                565                 570                 575     


Tyr Leu Leu Arg Gln Gly Asp Ala Leu Gln Ala Ile Tyr Phe Val Cys 
            580                 585                 590         


Ser Gly Ser Met Glu Val Leu Lys Asp Ser Met Val Leu Ala Ile Leu 
        595                 600                 605             


Gly Lys Gly Asp Leu Ile Gly Ala Asn Leu Ser Ile Lys Asp Gln Val 
    610                 615                 620                 


Ile Lys Thr Asn Ala Asp Val Lys Ala Leu Thr Tyr Cys Asp Leu Gln 
625                 630                 635                 640 


Cys Ile Ile Leu Lys Gly Leu Phe Glu Val Leu Asp Leu Tyr Pro Glu 
                645                 650                 655     


Tyr Ala His Lys Phe Val Glu Asp Ile Gln His Asp Leu Thr Tyr Asn 
            660                 665                 670         


Leu Arg Glu Gly His Glu Ser Asp Val Ile Ser Arg Leu Ser Asn Lys 
        675                 680                 685             


Ser Met Val Ser Gln Ser Glu Pro Lys Gly Asn Gly Asn Ile Asn Lys 
    690                 695                 700                 


Arg Leu Pro Ser Ile Val Glu Asp Glu Glu Glu Glu Glu Glu Gly Glu 
705                 710                 715                 720 


Glu Glu Glu Ala Val Ser Leu Ser Pro Ile Cys Thr Arg Gly Ser Ser 
                725                 730                 735     


Ser Arg Asn Lys Lys Val Gly Ser Asn Lys Ala Tyr Leu Gly Leu Ser 
            740                 745                 750         


Leu Lys Gln Leu Ala Ser Gly Thr Val Pro Phe His Ser Pro Ile Arg 
        755                 760                 765             


Val Ser Arg Ser Asn Ser Pro Lys Thr Lys Gln Glu Ile Asp Pro Pro 
    770                 775                 780                 


Asn His Asn Lys Arg Lys Glu Lys Asn Leu Lys Leu Gln Leu Ser Thr 
785                 790                 795                 800 


Leu Asn Asn Ala Gly Pro Pro Asp Leu Ser Pro Arg Ile Val Asp Gly 
                805                 810                 815     


Ile Glu Asp Gly Asn Ser Ser Glu Glu Ser Gln Thr Phe Asp Phe Gly 
            820                 825                 830         


Ser Glu Arg Ile Arg Ser Glu Pro Arg Ile Ser Pro Pro Leu Gly Asp 
        835                 840                 845             


Pro Glu Ile Gly Ala Ala Val Leu Phe Ile Lys Ala Glu Glu Thr Lys 
    850                 855                 860                 


Gln Gln Ile Asn Lys Leu Asn Ser Glu Val Thr Thr Leu Thr Gln Glu 
865                 870                 875                 880 


Val Ser Gln Leu Gly Lys Asp Met Arg Asn Val Ile Gln Leu Leu Glu 
                885                 890                 895     


Asn Val Leu Ser Pro Gln Gln Pro Ser Arg Phe Cys Ser Leu His Ser 
            900                 905                 910         


Thr Ser Val Cys Pro Ser Arg Glu Ser Leu Gln Thr Arg Thr Ser Trp 
        915                 920                 925             


Ser Ala His Gln Pro Cys Leu His Leu Gln Thr Gly Gly Ala Ala Tyr 
    930                 935                 940                 


Thr Gln Ala Gln Leu Cys Ser Ser Asn Ile Thr Ser Asp Ile Trp Ser 
945                 950                 955                 960 


Val Asp Pro Ser Ser Val Gly Ser Ser Pro Gln Arg Thr Gly Ala His 
                965                 970                 975     


Glu Gln Asn Pro Ala Asp Ser Glu Leu Tyr His Ser Pro Ser Leu Asp 
            980                 985                 990         


Tyr Ser Pro Ser His Tyr Gln Val  Val Gln Glu Gly His  Leu Gln Phe 
        995                 1000                 1005             


Leu Arg  Cys Ile Ser Pro His  Ser Asp Ser Thr Leu  Thr Pro Leu 
    1010                 1015                 1020             


Gln Ser  Ile Ser Ala Thr Leu  Ser Ser Ser Val Cys  Ser Ser Ser 
    1025                 1030                 1035             


Glu Thr  Ser Leu His Leu Val  Leu Pro Ser Arg Ser  Glu Glu Gly 
    1040                 1045                 1050             


Ser Phe  Ser Gln Gly Thr Val  Ser Ser Phe Ser Leu  Glu Asn Leu 
    1055                 1060                 1065             


Pro Gly  Ser Trp Asn Gln Glu  Gly Met Ala Ser Ala  Ser Thr Lys 
    1070                 1075                 1080             


Pro Leu  Glu Asn Leu Pro Leu  Glu Val Val Thr Ser  Thr Ala Glu 
    1085                 1090                 1095             


Val Lys  Asp Asn Lys Ala Ile  Asn Val 
    1100                 1105         


<210>  5881
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  5881

Met Ala Glu Arg Pro Gly Pro Pro Gly Gly Ala Val Ser Ala Thr Ala 
1               5                   10                  15      


Tyr Pro Asp Thr Pro Ala Glu Phe Pro Pro His Leu Gln Ala Gly Ala 
            20                  25                  30          


Met Arg Arg Arg Phe Trp Gly Val Phe Asn Cys Leu Cys Ala Gly Ala 
        35                  40                  45              


Phe Gly Ala Leu Ala Ala Ala Ser Ala Lys Leu Ala Phe Gly Ser Glu 
    50                  55                  60                  


Val Ser Met Gly Leu Cys Val Leu Gly Ile Ile Val Met Ala Ser Thr 
65                  70                  75                  80  


Asn Ser Leu Met Trp Thr Phe Phe Ser Arg Gly Leu Ser Phe Ser Met 
                85                  90                  95      


Ser Ser Ala Ile Ala Ser Val Thr Val Thr Phe Ser Asn Ile Leu Ser 
            100                 105                 110         


Ser Ala Phe Leu Gly Tyr Val Leu Tyr Gly Glu Cys Gln Glu Val Leu 
        115                 120                 125             


Trp Trp Gly Gly Val Phe Leu Ile Leu Cys Gly Leu Thr Leu Ile His 
    130                 135                 140                 


Arg Lys Leu Pro Pro Thr Trp Lys Pro Leu Pro His Lys Gln Gln 
145                 150                 155                 


<210>  5882
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  5882

Met Cys Met Val Ile Phe Ala Pro Leu Phe Ala Ile Phe Ala Phe Ala 
1               5                   10                  15      


Thr Cys Gly Gly Tyr Ser Gly Gly Leu Arg Leu Ser Val Asp Cys Val 
            20                  25                  30          


Asn Lys Thr Glu Ser Asn Leu Ser Ile Asp Ile Ala Phe Ala Tyr Pro 
        35                  40                  45              


Phe Arg Leu His Gln Val Thr Phe Glu Val Pro Thr Cys Glu Gly Lys 
    50                  55                  60                  


Glu Arg Gln Lys Leu Ala Leu Ile Gly Asp Ser Ser Ser Ser Ala Glu 
65                  70                  75                  80  


Phe Phe Val Thr Val Ala Val Phe Ala Phe Leu Tyr Ser Leu Ala Ala 
                85                  90                  95      


Thr Val Val Tyr Ile Phe Phe Gln Asn Lys Tyr Arg Glu Asn Asn Arg 
            100                 105                 110         


Gly Pro Leu Ile Asp Phe Ile Val Thr Val Val Phe Ser Phe Leu Trp 
        115                 120                 125             


Leu Val Gly Ser Ser Ala Trp Ala Lys Gly Leu Ser Asp Val Lys Val 
    130                 135                 140                 


Ala Thr Asp Pro Lys Glu Val Leu Leu Leu Met Ser Ala Cys Lys Gln 
145                 150                 155                 160 


Pro Ser Asn Lys Cys Met Ala Ile His Ser Pro Val Met Ser Ser Leu 
                165                 170                 175     


Asn Thr Ser Val Val Phe Gly Phe Leu Asn Phe Ile Leu Trp Ala Gly 
            180                 185                 190         


Asn Ile Trp Phe Val Phe Lys Glu Thr Gly Trp His Ser Ser Gly Gln 
        195                 200                 205             


Arg Tyr Leu Ser Asp Pro Met Glu Lys His Ser Ser Ser Tyr Asn Gln 
    210                 215                 220                 


Gly Gly Tyr Asn Gln Asp Ser Tyr Gly Ser Ser Ser Gly Tyr Ser Gln 
225                 230                 235                 240 


Gln Ala Ser Leu Gly Pro Thr Ser Asp Glu Phe Gly Gln Gln Pro Thr 
                245                 250                 255     


Gly Pro Thr Ser Phe Thr Asn Gln Ile 
            260                 265 


<210>  5883
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  5883

Met Tyr Arg Ile Ser Gln Leu Met Ser Thr Pro Val Ala Ser Ser Ser 
1               5                   10                  15      


Arg Leu Glu Arg Glu Tyr Ala Gly Glu Leu Ser Pro Thr Cys Ile Phe 
            20                  25                  30          


Pro Ser Phe Thr Cys Asp Ser Leu Asp Gly Tyr His Ser Phe Glu Cys 
        35                  40                  45              


Gly Ser Ile Asp Pro Leu Thr Gly Ser His Tyr Thr Cys Arg Arg Ser 
    50                  55                  60                  


Pro Arg Leu Leu Thr Asn Gly Tyr Tyr Ile Trp Thr Glu Asp Ser Phe 
65                  70                  75                  80  


Leu Cys Asp Lys Asp Gly Asn Ile Thr Leu Asn Pro Ser Gln Thr Ser 
                85                  90                  95      


Val Met Tyr Lys Glu Asn Leu Val Ser Thr Ser Lys Ser Trp Leu His 
            100                 105                 110         


Gly Ser Ile Phe Gly Asp Ile Asn Ser Ser Pro Ser Glu Asp Asn Trp 
        115                 120                 125             


Leu Lys Gly Thr Arg Arg Leu Asp Thr Asp His Cys Asn Gly Asn Ala 
    130                 135                 140                 


Asp Asp Leu Asp Cys Ser Ser Leu Thr Asp Asp Trp Glu Ser Gly Lys 
145                 150                 155                 160 


Met Asn Ala Glu Ser Val Ile Thr Ser Ser Ser Ser His Ile Ile Ser 
                165                 170                 175     


Gln Pro Pro Gly Gly Asn Ser His Ser Leu Ser Leu Gln Ser Gln Leu 
            180                 185                 190         


Thr Ala Ser Glu Arg Phe Gln Glu Asn Ser Ser Asp His Ser Glu Thr 
        195                 200                 205             


Arg Leu Leu Gln Glu Val Phe Phe Gln Ala Ile Leu Leu Ala Val Cys 
    210                 215                 220                 


Leu Ile Ile Ser Ala Cys Ala Arg Trp Phe Met Gly Glu Ile Leu Ala 
225                 230                 235                 240 


Ser Val Phe Thr Cys Ser Leu Met Ile Thr Val Ala Tyr Val Lys Ser 
                245                 250                 255     


Leu Phe Leu Ser Leu Ala Ser Tyr Phe Lys Thr Thr Ala Cys Ala Arg 
            260                 265                 270         


Phe Val Lys Ile 
        275     


<210>  5884
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  5884

Met Lys Asn Tyr Glu Ser Lys Lys Tyr Ser Asp Pro Ser Gln Pro Gly 
1               5                   10                  15      


Asn Thr Val Leu His Pro Gly Thr Arg Leu Ile Gln Lys Leu His Thr 
            20                  25                  30          


Ser Thr Cys Trp Leu Gln Glu Val Pro Gly Lys Pro Gln Leu Glu Gln 
        35                  40                  45              


Ala Thr Lys His Pro Gln Val Thr Ser Pro Gln Ala Thr Lys Glu Thr 
    50                  55                  60                  


Gly Met Glu Ile Lys Glu Gly Lys Gln Ser Tyr Arg Gln Lys Ile Met 
65                  70                  75                  80  


Asp Glu Leu Lys Tyr Tyr Tyr Asn Gly Phe Tyr Leu Leu Trp Ile Asp 
                85                  90                  95      


Ala Lys Val Ala Ala Arg Met Val Trp Arg Leu Leu His Gly Gln Val 
            100                 105                 110         


Leu Thr Arg Arg Glu Arg Arg Arg Glu Glu Lys Gln Lys Lys Lys Met 
        115                 120                 125             


Ala Val Lys Leu Glu Leu Ala Lys Phe Leu Gln Glu Thr Met Thr Glu 
    130                 135                 140                 


Met Ala Arg Arg Asn Arg Ala Lys Met Gly Asp Ala Ser Thr Gln Leu 
145                 150                 155                 160 


Ser Ser Tyr Val Lys Gln Val Gln Thr Gly His Lys Pro Ser Thr Lys 
                165                 170                 175     


Glu Ile Val Arg Phe Ser Lys Leu Phe Glu Asp Gln Leu Ala Leu Glu 
            180                 185                 190         


His Leu Asp Arg Pro Gln Leu Val Ala Leu Cys Lys Leu Leu Glu Leu 
        195                 200                 205             


Gln Thr Phe Gly Thr Asn Asn Leu Leu Arg Phe Gln Leu Leu Met Lys 
    210                 215                 220                 


Leu Lys Ser Ile Lys Ala Asp Asp Glu Ile Ile Ala Lys Glu Gly Val 
225                 230                 235                 240 


Thr Ala Leu Ser Val Ser Glu Leu Gln Ala Ala Cys Arg Ala Arg Gly 
                245                 250                 255     


Met Arg Ser Leu Gly Leu Thr Glu Glu Gln Leu Arg Gln Gln Leu Thr 
            260                 265                 270         


Glu Trp Gln Asp Leu His Leu Lys Glu Asn Val Pro Pro Ser Leu Leu 
        275                 280                 285             


Leu Leu Ser Arg Thr Phe Tyr Leu Ile Asp Val Lys Pro Lys Pro Ile 
    290                 295                 300                 


Glu Ile Pro Leu Ser Gly Glu Ala Pro Lys Thr Asp Ile Leu Val Glu 
305                 310                 315                 320 


Leu Pro Thr Phe Thr Glu Ser Lys Glu Asn Met Val Asp Leu Ala Pro 
                325                 330                 335     


Gln Leu Lys Gly Thr Lys Asp Glu Asp Phe Ile Gln Pro Pro Pro Val 
            340                 345                 350         


Thr Ser Ser Pro Ile Thr Pro Ser Thr Pro Ile Ser Leu Pro Lys Gly 
        355                 360                 365             


Pro Ile Thr Ser Ser Glu Glu Pro Thr Leu Gln Ala Lys Ser Gln Met 
    370                 375                 380                 


Thr Ala Gln Asn Ser Lys Ala Ser Ser Lys Gly Ala 
385                 390                 395     


<210>  5885
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  5885

Met Ala Gly Pro Asn Gln Leu Cys Ile Arg Arg Trp Thr Thr Lys His 
1               5                   10                  15      


Val Ala Val Trp Leu Lys Asp Glu Gly Phe Phe Glu Tyr Val Asp Ile 
            20                  25                  30          


Leu Cys Asn Lys His Arg Leu Asp Gly Ile Thr Leu Leu Thr Leu Thr 
        35                  40                  45              


Glu Tyr Asp Leu Arg Ser Pro Pro Leu Glu Ile Lys Val Leu Gly Asp 
    50                  55                  60                  


Ile Lys Arg Leu Met Leu Ser Val Arg Lys Leu Gln Lys Ile His Ile 
65                  70                  75                  80  


Asp Val Leu Glu Glu Met Gly Tyr Asn Ser Asp Ser Pro Met Gly Ser 
                85                  90                  95      


Met Thr Pro Phe Ile Ser Ala Leu Gln Ser Thr Asp Trp Leu Cys Asn 
            100                 105                 110         


Gly Glu Leu Ser His Asp Cys Asp Gly Pro Ile Thr Asp Leu Asn Ser 
        115                 120                 125             


Asp Gln Tyr Gln Tyr Met Asn Gly Lys Asn Lys His Ser Val Arg Arg 
    130                 135                 140                 


Leu Asp Pro Glu Tyr Trp Lys Thr Ile Leu Ser Cys Ile Tyr Val Phe 
145                 150                 155                 160 


Ile Val Phe Gly Phe Thr Ser Phe Ile Met Val Ile Val His Glu Arg 
                165                 170                 175     


Val Pro Asp Met Gln Thr Tyr Pro Pro Leu Pro Asp Ile Phe Leu Asp 
            180                 185                 190         


Ser Val Pro Arg Ile Pro Trp Ala Phe Ala Met Thr Glu Val Cys Gly 
        195                 200                 205             


Met Ile Leu Cys Tyr Ile Trp Leu Leu Val Leu Leu Leu His Lys His 
    210                 215                 220                 


Arg Ser Ile Leu Leu Arg Arg Leu Cys Ser Leu Met Gly Thr Val Phe 
225                 230                 235                 240 


Leu Leu Arg Cys Phe Thr Met Phe Val Thr Ser Leu Ser Val Pro Gly 
                245                 250                 255     


Gln His Leu Gln Cys Thr Gly Lys Ile Tyr Gly Ser Val Trp Glu Lys 
            260                 265                 270         


Leu His Arg Ala Phe Ala Ile Trp Ser Gly Phe Gly Met Thr Leu Thr 
        275                 280                 285             


Gly Val His Thr Cys Gly Asp Tyr Met Phe Ser Gly His Thr Val Val 
    290                 295                 300                 


Leu Thr Met Leu Asn Phe Phe Val Thr Glu Cys Lys Tyr Leu Phe Ser 
305                 310                 315                 320 


Ala Ser Met Arg Ile Arg 
                325     


<210>  5886
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  5886

Met Ala Ala Ser Ala Leu Tyr Ala Cys Thr Lys Cys Thr Gln Arg Tyr 
1               5                   10                  15      


Pro Phe Glu Glu Leu Ser Gln Gly Gln Gln Leu Cys Lys Glu Cys Arg 
            20                  25                  30          


Ile Ala His Pro Ile Val Lys Cys Thr Tyr Cys Arg Ser Glu Phe Gln 
        35                  40                  45              


Gln Glu Ser Lys Thr Asn Thr Ile Cys Lys Lys Cys Ala Gln Asn Val 
    50                  55                  60                  


Lys Gln Phe Gly Thr Pro Lys Pro Cys Gln Tyr Cys Asn Ile Ile Ala 
65                  70                  75                  80  


Ala Phe Ile Gly Thr Lys Cys Gln Arg Cys Thr Asn Ser Glu Lys Lys 
                85                  90                  95      


Tyr Gly Pro Pro Gln Thr Cys Glu Gln Cys Lys Gln Gln Cys Ala Phe 
            100                 105                 110         


Asp Arg Lys Glu Glu Gly Arg Arg Lys Val Asp Gly Lys Leu Leu Cys 
        115                 120                 125             


Trp Leu Cys Thr Leu Ser Tyr Lys Arg Val Leu Gln Lys Thr Lys Glu 
    130                 135                 140                 


Gln Arg Lys Ser Leu Gly Ser Ser His Ser Asn Ser Ser Ser Ser Ser 
145                 150                 155                 160 


Leu Thr Glu Lys Asp Gln His His Pro Lys His His His His His His 
                165                 170                 175     


His His His His Arg His Ser Ser Ser His His Lys Ile Ser Asn Leu 
            180                 185                 190         


Ser Pro Glu Glu Glu Gln Gly Leu Trp Lys Gln Ser His Lys Ser Ser 
        195                 200                 205             


Ala Thr Ile Gln Asn Glu Thr Pro Lys Lys Lys Pro Lys Leu Glu Ser 
    210                 215                 220                 


Lys Pro Ser Asn Gly Asp Ser Ser Ser Ile Asn Gln Ser Ala Asp Ser 
225                 230                 235                 240 


Gly Gly Thr Asp Asn Phe Val Leu Ile Ser Gln Leu Lys Glu Glu Val 
                245                 250                 255     


Met Ser Leu Lys Arg Leu Leu Gln Gln Arg Asp Gln Thr Ile Leu Glu 
            260                 265                 270         


Lys Asp Lys Lys Leu Thr Glu Leu Lys Ala Asp Phe Gln Tyr Gln Glu 
        275                 280                 285             


Ser Asn Leu Arg Thr Lys Met Asn Ser Met Glu Lys Ala His Lys Glu 
    290                 295                 300                 


Thr Val Glu Gln Leu Gln Ala Lys Asn Arg Glu Leu Leu Lys Gln Val 
305                 310                 315                 320 


Ala Ala Leu Ser Lys Gly Lys Lys Phe Asp Lys Ser Gly Ser Ile Leu 
                325                 330                 335     


Thr Ser Pro 
            


<210>  5887
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  5887

Met Ala Pro Lys Ala Ala Lys Gly Ala Lys Pro Glu Pro Ala Pro Ala 
1               5                   10                  15      


Pro Pro Pro Pro Gly Ala Lys Pro Glu Glu Asp Lys Lys Asp Gly Lys 
            20                  25                  30          


Glu Pro Ser Asp Lys Pro Gln Lys Ala Val Gln Asp His Lys Glu Pro 
        35                  40                  45              


Ser Asp Lys Pro Gln Lys Ala Val Gln Pro Lys His Glu Val Gly Thr 
    50                  55                  60                  


Arg Arg Gly Cys Arg Arg Tyr Arg Trp Glu Leu Lys Asp Ser Asn Lys 
65                  70                  75                  80  


Glu Phe Trp Leu Leu Gly His Ala Glu Ile Lys Ile Arg Ser Leu Gly 
                85                  90                  95      


Cys Leu Ile Ala Ala Met Ile Leu Leu Ser Ser Leu Thr Val His Pro 
            100                 105                 110         


Ile Leu Arg Leu Ile Ile Thr Met Glu Ile Ser Phe Phe Ser Phe Phe 
        115                 120                 125             


Ile Leu Leu Tyr Ser Phe Ala Ile His Arg Tyr Ile Pro Phe Ile Leu 
    130                 135                 140                 


Trp Pro Ile Ser Asp Leu Phe Asn Asp Leu Ile Ala Cys Ala Phe Leu 
145                 150                 155                 160 


Val Gly Ala Val Val Phe Ala Val Arg Ser Arg Arg Ser Met Asn Leu 
                165                 170                 175     


His Tyr Leu Leu Ala Val Ile Leu Ile Gly Ala Ala Gly Val Phe Ala 
            180                 185                 190         


Phe Ile Asp Val Cys Leu Gln Arg Asn His Phe Arg Gly Lys Lys Ala 
        195                 200                 205             


Lys Lys His Met Leu Val Pro Pro Pro Gly Lys Glu Lys Gly Pro Gln 
    210                 215                 220                 


Gln Gly Lys Gly Pro Glu Pro Ala Lys Pro Pro Glu Pro Gly Lys Pro 
225                 230                 235                 240 


Pro Gly Pro Ala Lys Gly Lys Lys 
                245             


<210>  5888
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  5888

Met Cys Leu Glu Leu Phe His Ser Ser Asn Val Ile Asp Gly Leu Lys 
1               5                   10                  15      


Leu Asn Ala Phe Ala Ala Val Phe Thr Val Leu Ser Gly Leu Leu Gly 
            20                  25                  30          


Met Val Ala His Met Met Tyr Thr Gln Val Phe Gln Val Thr Val Ser 
        35                  40                  45              


Leu Gly Pro Glu Asp Trp Arg Pro His Ser Trp Asp Tyr Gly Trp Ser 
    50                  55                  60                  


Phe Cys Leu Ala Trp Gly Ser Phe Thr Cys Cys Met Ala Ala Ser Val 
65                  70                  75                  80  


Thr Thr Leu Asn Ser Tyr Thr Lys Thr Val Ile Glu Phe Arg His Lys 
                85                  90                  95      


Arg Lys Val Phe Glu Gln Gly Tyr Arg Glu Glu Pro Thr Phe Ile Asp 
            100                 105                 110         


Pro Glu Ala Ile Lys Tyr Phe Arg Glu Arg Met Glu Lys Arg Asp Gly 
        115                 120                 125             


Ser Glu Glu Asp Phe His Leu Asp Cys Arg His Glu Arg Tyr Pro Ala 
    130                 135                 140                 


Arg His Gln Pro His Met Ala Asp Ser Trp Pro Arg Ser Ser Ala Gln 
145                 150                 155                 160 


Glu Ala Pro Glu Leu Asn Arg Gln Cys Trp Val Leu Gly His Trp Val 
                165                 170                 175     


<210>  5889
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  5889

Met Ser Pro Leu Leu Phe Gly Ala Gly Leu Val Val Leu Asn Leu Val 
1               5                   10                  15      


Thr Ser Ala Arg Ser Gln Lys Thr Glu Pro Leu Ser Gly Ser Gly Asp 
            20                  25                  30          


Gln Pro Leu Phe Arg Gly Ala Asp Arg Tyr Asp Phe Ala Ile Met Ile 
        35                  40                  45              


Pro Pro Gly Gly Thr Glu Cys Phe Trp Gln Phe Ala His Gln Thr Gly 
    50                  55                  60                  


Tyr Phe Tyr Phe Ser Tyr Glu Val Gln Arg Thr Val Gly Met Ser His 
65                  70                  75                  80  


Asp Arg His Val Ala Ala Thr Ala His Asn Pro Gln Gly Phe Leu Ile 
                85                  90                  95      


Asp Thr Ser Gln Gly Val Arg Gly Gln Ile Asn Phe Ser Thr Gln Glu 
            100                 105                 110         


Thr Gly Phe Tyr Gln Leu Cys Leu Ser Asn Gln His Asn His Phe Gly 
        115                 120                 125             


Ser Val Gln Val Tyr Leu Asn Phe Gly Val Phe Tyr Glu Gly Pro Glu 
    130                 135                 140                 


Thr Asp His Lys Gln Lys Glu Arg Lys Gln Leu Asn Asp Thr Leu Asp 
145                 150                 155                 160 


Ala Ile Glu Asp Gly Thr Gln Lys Val Gln Asn Asn Ile Phe His Met 
                165                 170                 175     


Trp Arg Tyr Tyr Asn Phe Ala Arg Met Arg Lys Met Ala Asp Phe Phe 
            180                 185                 190         


Leu Ile Gln Ser Asn Tyr Asn Tyr Val Asn Trp Trp Ser Thr Ala Gln 
        195                 200                 205             


Ser Leu Val Ile Ile Leu Ser Gly Ile Leu Gln Leu Tyr Phe Leu Lys 
    210                 215                 220                 


Arg Leu Phe Asn Val Pro Thr Thr Thr Asp Thr Lys Lys Pro Arg Cys 
225                 230                 235                 240 


<210>  5890
<211>  790
<212>  PRT
<213>  Homo sapiens

<400>  5890

Met Ile Thr Val Asn Pro Asp Gly Lys Ile Met Val Arg Arg Cys Leu 
1               5                   10                  15      


Val Thr Leu Arg Pro Phe Arg Leu Phe Val Leu Gly Ile Gly Phe Phe 
            20                  25                  30          


Thr Leu Cys Phe Leu Met Thr Ser Leu Gly Gly Gln Phe Ser Ala Arg 
        35                  40                  45              


Arg Leu Gly Asp Ser Pro Phe Thr Ile Arg Thr Glu Val Met Gly Gly 
    50                  55                  60                  


Pro Glu Ser Arg Gly Val Leu Arg Lys Met Ser Asp Leu Leu Glu Leu 
65                  70                  75                  80  


Met Val Lys Arg Met Asp Ala Leu Ala Arg Leu Glu Asn Ser Ser Glu 
                85                  90                  95      


Leu His Arg Ala Gly Gly Asp Leu His Phe Pro Ala Asp Arg Met Pro 
            100                 105                 110         


Pro Gly Ala Gly Leu Met Glu Arg Ile Gln Ala Ile Ala Gln Asn Val 
        115                 120                 125             


Ser Asp Ile Ala Val Lys Val Asp Gln Ile Leu Arg His Ser Leu Leu 
    130                 135                 140                 


Leu His Ser Lys Val Ser Glu Gly Arg Arg Asp Gln Cys Glu Ala Pro 
145                 150                 155                 160 


Ser Asp Pro Lys Phe Pro Asp Cys Ser Gly Lys Val Glu Trp Met Arg 
                165                 170                 175     


Ala Arg Trp Thr Ser Asp Pro Cys Tyr Ala Phe Phe Gly Val Asp Gly 
            180                 185                 190         


Thr Glu Cys Ser Phe Leu Ile Tyr Leu Ser Glu Val Glu Trp Phe Cys 
        195                 200                 205             


Pro Pro Leu Pro Trp Arg Asn Gln Thr Ala Ala Gln Arg Ala Pro Lys 
    210                 215                 220                 


Pro Leu Pro Lys Val Gln Ala Val Phe Arg Ser Asn Leu Ser His Leu 
225                 230                 235                 240 


Leu Asp Leu Met Gly Ser Gly Lys Glu Ser Leu Ile Phe Met Lys Lys 
                245                 250                 255     


Arg Thr Lys Arg Leu Thr Ala Gln Trp Ala Leu Ala Ala Gln Arg Leu 
            260                 265                 270         


Ala Gln Lys Leu Gly Ala Thr Gln Arg Asp Gln Lys Gln Ile Leu Val 
        275                 280                 285             


His Ile Gly Phe Leu Thr Glu Glu Ser Gly Asp Val Phe Ser Pro Arg 
    290                 295                 300                 


Val Leu Lys Gly Gly Pro Leu Gly Glu Met Val Gln Trp Ala Asp Ile 
305                 310                 315                 320 


Leu Thr Ala Leu Tyr Val Leu Gly His Gly Leu Arg Val Thr Val Ser 
                325                 330                 335     


Leu Lys Glu Leu Gln Ser Asn Leu Gly Val Pro Pro Gly Arg Gly Ser 
            340                 345                 350         


Cys Pro Leu Thr Met Pro Leu Pro Phe Asp Leu Ile Tyr Thr Asp Tyr 
        355                 360                 365             


His Gly Leu Gln Gln Met Lys Arg His Met Gly Leu Ser Phe Lys Lys 
    370                 375                 380                 


Tyr Arg Cys Arg Ile Arg Val Ile Asp Thr Phe Gly Thr Glu Pro Ala 
385                 390                 395                 400 


Tyr Asn His Glu Glu Tyr Ala Thr Leu His Gly Tyr Arg Thr Asn Trp 
                405                 410                 415     


Gly Tyr Trp Asn Leu Asn Pro Lys Gln Phe Met Thr Met Phe Pro His 
            420                 425                 430         


Thr Pro Asp Asn Ser Phe Met Gly Phe Val Ser Glu Glu Leu Asn Glu 
        435                 440                 445             


Thr Glu Lys Arg Leu Ile Lys Gly Gly Lys Ala Ser Asn Met Ala Val 
    450                 455                 460                 


Val Tyr Gly Lys Glu Ala Ser Ile Trp Lys Gly Lys Glu Lys Phe Leu 
465                 470                 475                 480 


Gly Ile Leu Asn Lys Tyr Met Glu Ile His Gly Thr Val Tyr Tyr Glu 
                485                 490                 495     


Ser Gln Arg Pro Pro Glu Val Pro Ala Phe Val Lys Asn His Gly Leu 
            500                 505                 510         


Leu Pro Gln Pro Glu Phe Gln Gln Leu Leu Arg Lys Ala Lys Leu Phe 
        515                 520                 525             


Ile Gly Phe Gly Phe Pro Tyr Glu Gly Pro Ala Pro Leu Glu Ala Ile 
    530                 535                 540                 


Ala Asn Gly Cys Ile Phe Leu Gln Ser Arg Phe Ser Pro Pro His Ser 
545                 550                 555                 560 


Ser Leu Asn His Glu Phe Phe Arg Gly Lys Pro Thr Ser Arg Glu Val 
                565                 570                 575     


Phe Ser Gln His Pro Tyr Ala Glu Asn Phe Ile Gly Lys Pro His Val 
            580                 585                 590         


Trp Thr Val Asp Tyr Asn Asn Ser Glu Glu Phe Glu Ala Ala Ile Lys 
        595                 600                 605             


Ala Ile Met Arg Thr Gln Val Asp Pro Tyr Leu Pro Tyr Glu Tyr Thr 
    610                 615                 620                 


Cys Glu Gly Met Leu Glu Arg Ile His Ala Tyr Ile Gln His Gln Asp 
625                 630                 635                 640 


Phe Cys Arg Ala Pro Asp Pro Ala Leu Pro Glu Ala His Ala Pro Gln 
                645                 650                 655     


Ser Pro Phe Val Leu Ala Pro Asn Ala Thr His Leu Glu Trp Ala Arg 
            660                 665                 670         


Asn Thr Ser Leu Ala Pro Gly Ala Trp Pro Pro Ala His Ala Leu Arg 
        675                 680                 685             


Ala Trp Leu Ala Val Pro Gly Arg Ala Cys Thr Asp Thr Cys Leu Asp 
    690                 695                 700                 


His Gly Leu Ile Cys Glu Pro Ser Phe Phe Pro Phe Leu Asn Ser Gln 
705                 710                 715                 720 


Asp Ala Phe Leu Lys Leu Gln Val Pro Cys Asp Ser Thr Glu Ser Glu 
                725                 730                 735     


Met Asn His Leu Tyr Pro Ala Phe Ala Gln Pro Gly Gln Glu Cys Tyr 
            740                 745                 750         


Leu Gln Lys Glu Pro Leu Leu Phe Ser Cys Ala Gly Ser Asn Thr Lys 
        755                 760                 765             


Tyr Arg Arg Leu Cys Pro Cys Arg Asp Phe Arg Lys Gly Gln Val Ala 
    770                 775                 780                 


Leu Cys Gln Gly Cys Leu 
785                 790 


<210>  5891
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  5891

Met Glu Ala Leu Leu Leu Gly Ala Gly Leu Leu Leu Gly Ala Tyr Val 
1               5                   10                  15      


Leu Val Tyr Tyr Asn Leu Val Lys Ala Pro Pro Cys Gly Gly Met Gly 
            20                  25                  30          


Asn Leu Arg Gly Arg Thr Ala Val Val Thr Gly Ala Asn Ser Gly Ile 
        35                  40                  45              


Gly Lys Met Thr Ala Leu Glu Leu Ala Arg Arg Gly Ala Arg Val Val 
    50                  55                  60                  


Leu Ala Cys Arg Ser Gln Glu Arg Gly Glu Ala Ala Ala Phe Asp Leu 
65                  70                  75                  80  


Arg Gln Glu Ser Gly Asn Asn Glu Val Ile Phe Met Ala Leu Asp Leu 
                85                  90                  95      


Ala Ser Leu Ala Ser Val Arg Ala Phe Ala Thr Ala Phe Leu Ser Ser 
            100                 105                 110         


Glu Pro Arg Leu Asp Ile Leu Ile His Asn Ala Gly Ile Ser Ser Cys 
        115                 120                 125             


Gly Arg Thr Arg Glu Ala Phe Asn Leu Leu Leu Arg Val Asn His Ile 
    130                 135                 140                 


Gly Pro Phe Leu Leu Thr His Leu Leu Leu Pro Cys Leu Lys Ala Cys 
145                 150                 155                 160 


Ala Pro Ser Arg Val Val Val Val Ala Ser Ala Ala His Cys Arg Gly 
                165                 170                 175     


Arg Leu Asp Phe Lys Arg Leu Asp Arg Pro Val Val Gly Trp Arg Gln 
            180                 185                 190         


Glu Leu Arg Ala Tyr Ala Asp Thr Lys Leu Ala Asn Val Leu Phe Ala 
        195                 200                 205             


Arg Glu Leu Ala Asn Gln Leu Glu Ala Thr Gly Val Thr Cys Tyr Ala 
    210                 215                 220                 


Ala His Pro Gly Pro Val Asn Ser Glu Leu Phe Leu Arg His Val Pro 
225                 230                 235                 240 


Gly Trp Leu Arg Pro Leu Leu Arg Pro Leu Ala Trp Leu Val Leu Arg 
                245                 250                 255     


Ala Pro Arg Gly Gly Ala Gln Thr Pro Leu Tyr Cys Ala Leu Gln Glu 
            260                 265                 270         


Gly Ile Glu Pro Leu Ser Gly Arg Tyr Phe Ala Asn Cys His Val Glu 
        275                 280                 285             


Glu Val Pro Pro Ala Ala Arg Asp Asp Arg Ala Ala His Arg Leu Trp 
    290                 295                 300                 


Glu Ala Ser Lys Arg Leu Ala Gly Leu Gly Pro Gly Glu Asp Ala Glu 
305                 310                 315                 320 


Pro Asp Glu Asp Pro Gln Ser Glu Asp Ser Glu Ala Pro Ser Ser Leu 
                325                 330                 335     


Ser Thr Pro His Pro Glu Glu Pro Thr Val Ser Gln Pro Tyr Pro Ser 
            340                 345                 350         


Pro Gln Ser Ser Pro Asp Leu Ser Lys Met Thr His Arg Ile Gln Ala 
        355                 360                 365             


Lys Val Glu Pro Glu Ile Gln Leu Ser 
    370                 375         


<210>  5892
<211>  706
<212>  PRT
<213>  Homo sapiens

<400>  5892

Met Glu Glu Asn Pro Thr Leu Glu Ser Glu Ala Trp Gly Ser Ser Arg 
1               5                   10                  15      


Glu Trp Leu Ala Pro Arg Glu Ala Arg Gly Gly Pro Ser Leu Ser Ser 
            20                  25                  30          


Val Leu Asn Glu Leu Pro Ser Ala Ala Thr Leu Arg Tyr Arg Asp Pro 
        35                  40                  45              


Gly Val Leu Pro Trp Gly Ala Leu Glu Glu Glu Glu Glu Asp Gly Gly 
    50                  55                  60                  


Arg Ser Arg Lys Ala Phe Thr Glu Val Thr Gln Thr Glu Leu Gln Asp 
65                  70                  75                  80  


Pro His Pro Ser Arg Glu Leu Pro Trp Pro Met Gln Ala Arg Arg Ala 
                85                  90                  95      


His Arg Gln Arg Asn Ala Ser Arg Asp Gln Val Val Tyr Gly Ser Gly 
            100                 105                 110         


Thr Lys Thr Asp Arg Trp Ala Arg Leu Leu Arg Arg Ser Lys Glu Lys 
        115                 120                 125             


Thr Lys Glu Gly Leu Arg Ser Leu Gln Pro Trp Ala Trp Thr Leu Lys 
    130                 135                 140                 


Arg Ile Gly Gly Gln Phe Gly Ala Gly Thr Glu Ser Tyr Phe Ser Leu 
145                 150                 155                 160 


Leu Arg Phe Leu Leu Leu Leu Asn Val Leu Ala Ser Val Leu Met Ala 
                165                 170                 175     


Cys Met Thr Leu Leu Pro Thr Trp Leu Gly Gly Ala Pro Pro Gly Pro 
            180                 185                 190         


Pro Gly Pro Asp Ile Ser Ser Pro Cys Gly Ser Tyr Asn Pro His Ser 
        195                 200                 205             


Gln Gly Leu Val Thr Phe Ala Thr Gln Leu Phe Asn Leu Leu Ser Gly 
    210                 215                 220                 


Glu Gly Tyr Leu Glu Trp Ser Pro Leu Phe Tyr Gly Phe Tyr Pro Pro 
225                 230                 235                 240 


Arg Pro Arg Leu Ala Val Thr Tyr Leu Cys Trp Ala Phe Ala Val Gly 
                245                 250                 255     


Leu Ile Cys Leu Leu Leu Ile Leu His Arg Ser Val Ser Gly Leu Lys 
            260                 265                 270         


Gln Thr Leu Leu Ala Glu Ser Glu Ala Leu Thr Ser Tyr Ser His Arg 
        275                 280                 285             


Val Phe Ser Ala Trp Asp Phe Gly Leu Cys Gly Asp Val His Val Arg 
    290                 295                 300                 


Leu Arg Gln Arg Ile Ile Leu Tyr Glu Leu Lys Val Glu Leu Glu Glu 
305                 310                 315                 320 


Thr Val Val Arg Arg Gln Ala Ala Val Arg Thr Leu Gly Gln Gln Ala 
                325                 330                 335     


Arg Val Trp Leu Val Arg Val Leu Leu Asn Leu Leu Val Val Ala Leu 
            340                 345                 350         


Leu Gly Ala Ala Phe Tyr Gly Val Tyr Trp Ala Thr Gly Cys Thr Val 
        355                 360                 365             


Glu Leu Gln Glu Met Pro Leu Val Gln Glu Leu Pro Leu Leu Lys Leu 
    370                 375                 380                 


Gly Val Asn Tyr Leu Pro Ser Ile Phe Ile Ala Gly Val Asn Phe Val 
385                 390                 395                 400 


Leu Pro Pro Val Phe Lys Leu Ile Ala Pro Leu Glu Gly Tyr Thr Arg 
                405                 410                 415     


Ser Arg Gln Ile Val Phe Ile Leu Leu Arg Thr Val Phe Leu Arg Leu 
            420                 425                 430         


Ala Ser Leu Val Val Leu Leu Phe Ser Leu Trp Asn Gln Ile Thr Cys 
        435                 440                 445             


Gly Gly Asp Ser Glu Ala Glu Asp Cys Lys Thr Cys Gly Tyr Asn Tyr 
    450                 455                 460                 


Lys Gln Leu Pro Cys Trp Glu Thr Val Leu Gly Gln Glu Met Tyr Lys 
465                 470                 475                 480 


Leu Leu Leu Phe Asp Leu Leu Thr Val Leu Ala Val Ala Leu Leu Ile 
                485                 490                 495     


Gln Phe Pro Arg Lys Leu Leu Cys Gly Leu Cys Pro Gly Ala Leu Gly 
            500                 505                 510         


Arg Leu Ala Gly Thr Gln Glu Phe Gln Val Pro Asp Glu Val Leu Gly 
        515                 520                 525             


Leu Ile Tyr Ala Gln Thr Val Val Trp Val Gly Ser Phe Phe Cys Pro 
    530                 535                 540                 


Leu Leu Pro Leu Leu Asn Thr Val Lys Phe Leu Leu Leu Phe Tyr Leu 
545                 550                 555                 560 


Lys Lys Leu Thr Leu Phe Ser Thr Cys Ser Pro Ala Ala Arg Thr Phe 
                565                 570                 575     


Arg Ala Ser Ala Ala Asn Phe Phe Phe Pro Leu Val Leu Leu Leu Gly 
            580                 585                 590         


Leu Ala Ile Ser Ser Val Pro Leu Leu Tyr Ser Ile Phe Leu Ile Pro 
        595                 600                 605             


Pro Ser Lys Leu Cys Gly Pro Phe Arg Gly Gln Ser Ser Ile Trp Ala 
    610                 615                 620                 


Gln Ile Pro Glu Ser Ile Ser Ser Leu Pro Glu Thr Thr Gln Asn Phe 
625                 630                 635                 640 


Leu Phe Phe Leu Gly Thr Gln Ala Phe Ala Val Pro Leu Leu Leu Ile 
                645                 650                 655     


Ser Ser Ile Leu Met Ala Tyr Thr Val Ala Leu Ala Asn Ser Tyr Gly 
            660                 665                 670         


Arg Leu Ile Ser Glu Leu Lys Arg Gln Arg Glu Thr Glu Ala Gln Asn 
        675                 680                 685             


Lys Val Phe Leu Ala Arg Arg Ala Val Ala Leu Thr Ser Thr Lys Pro 
    690                 695                 700                 


Ala Leu 
705     


<210>  5893
<211>  1029
<212>  PRT
<213>  Homo sapiens

<400>  5893

Met Gly Leu Trp Gly Lys Lys Gly Thr Val Ala Pro His Asp Gln Ser 
1               5                   10                  15      


Pro Arg Arg Arg Pro Lys Lys Gly Leu Ile Lys Lys Lys Met Val Lys 
            20                  25                  30          


Arg Glu Lys Gln Lys Arg Asn Met Glu Glu Leu Lys Lys Glu Val Val 
        35                  40                  45              


Met Asp Asp His Lys Leu Thr Leu Glu Glu Leu Ser Thr Lys Tyr Ser 
    50                  55                  60                  


Val Asp Leu Thr Lys Gly His Ser His Gln Arg Ala Lys Glu Ile Leu 
65                  70                  75                  80  


Thr Arg Gly Gly Pro Asn Thr Val Thr Pro Pro Pro Thr Thr Pro Glu 
                85                  90                  95      


Trp Val Lys Phe Cys Lys Gln Leu Phe Gly Gly Phe Ser Leu Leu Leu 
            100                 105                 110         


Trp Thr Gly Ala Ile Leu Cys Phe Val Ala Tyr Ser Ile Gln Ile Tyr 
        115                 120                 125             


Phe Asn Glu Glu Pro Thr Lys Asp Asn Leu Tyr Leu Ser Ile Val Leu 
    130                 135                 140                 


Ser Val Val Val Ile Val Thr Gly Cys Phe Ser Tyr Tyr Gln Glu Ala 
145                 150                 155                 160 


Lys Ser Ser Lys Ile Met Glu Ser Phe Lys Asn Met Val Pro Gln Gln 
                165                 170                 175     


Ala Leu Val Ile Arg Gly Gly Glu Lys Met Gln Ile Asn Val Gln Glu 
            180                 185                 190         


Val Val Leu Gly Asp Leu Val Glu Ile Lys Gly Gly Asp Arg Val Pro 
        195                 200                 205             


Ala Asp Leu Arg Leu Ile Ser Ala Gln Gly Cys Lys Val Asp Asn Ser 
    210                 215                 220                 


Ser Leu Thr Gly Glu Ser Glu Pro Gln Ser Arg Ser Pro Asp Phe Thr 
225                 230                 235                 240 


His Glu Asn Pro Leu Glu Thr Arg Asn Ile Cys Phe Phe Ser Thr Asn 
                245                 250                 255     


Cys Val Glu Gly Thr Ala Arg Gly Ile Val Ile Ala Thr Gly Asp Ser 
            260                 265                 270         


Thr Val Met Gly Arg Ile Ala Ser Leu Thr Ser Gly Leu Ala Val Gly 
        275                 280                 285             


Gln Thr Pro Ile Ala Ala Glu Ile Glu His Phe Ile His Leu Ile Thr 
    290                 295                 300                 


Val Val Ala Val Phe Leu Gly Val Thr Phe Phe Ala Leu Ser Leu Leu 
305                 310                 315                 320 


Leu Gly Tyr Gly Trp Leu Glu Ala Ile Ile Phe Leu Ile Gly Ile Ile 
                325                 330                 335     


Val Ala Asn Val Pro Glu Gly Leu Leu Ala Thr Val Thr Val Cys Leu 
            340                 345                 350         


Thr Leu Thr Ala Lys Arg Met Ala Arg Lys Asn Cys Leu Val Lys Asn 
        355                 360                 365             


Leu Glu Ala Val Glu Thr Leu Gly Ser Thr Ser Thr Ile Cys Ser Asp 
    370                 375                 380                 


Lys Thr Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ala His Met Trp 
385                 390                 395                 400 


Phe Asp Met Thr Val Tyr Glu Ala Asp Thr Thr Glu Glu Gln Thr Gly 
                405                 410                 415     


Lys Thr Phe Thr Lys Ser Ser Asp Thr Trp Phe Met Leu Ala Arg Ile 
            420                 425                 430         


Ala Gly Leu Cys Asn Arg Ala Asp Phe Lys Ala Asn Gln Glu Ile Leu 
        435                 440                 445             


Pro Ile Ala Lys Arg Ala Thr Thr Gly Asp Ala Ser Glu Ser Ala Leu 
    450                 455                 460                 


Leu Lys Phe Ile Glu Gln Ser Tyr Ser Ser Val Ala Glu Met Arg Glu 
465                 470                 475                 480 


Lys Asn Pro Lys Val Ala Glu Ile Pro Phe Asn Ser Thr Asn Lys Tyr 
                485                 490                 495     


Gln Met Ser Ile His Leu Arg Glu Asp Ser Ser Gln Thr His Val Leu 
            500                 505                 510         


Met Met Lys Gly Ala Pro Glu Arg Ile Leu Glu Phe Cys Ser Thr Phe 
        515                 520                 525             


Leu Leu Asn Gly Gln Glu Tyr Ser Met Asn Asp Glu Met Lys Glu Ala 
    530                 535                 540                 


Phe Gln Asn Ala Tyr Leu Glu Leu Gly Gly Leu Gly Glu Arg Val Leu 
545                 550                 555                 560 


Gly Phe Cys Phe Leu Asn Leu Pro Ser Ser Phe Ser Lys Gly Phe Pro 
                565                 570                 575     


Phe Asn Thr Asp Glu Ile Asn Phe Pro Met Asp Asn Leu Cys Phe Val 
            580                 585                 590         


Gly Leu Ile Ser Met Ile Asp Pro Pro Arg Ala Ala Val Pro Asp Ala 
        595                 600                 605             


Val Ser Lys Cys Arg Ser Ala Gly Ile Lys Val Ile Met Val Thr Gly 
    610                 615                 620                 


Asp His Pro Ile Thr Ala Lys Ala Ile Ala Lys Gly Val Gly Ile Ile 
625                 630                 635                 640 


Ser Glu Gly Thr Glu Thr Ala Glu Glu Val Ala Ala Arg Leu Lys Ile 
                645                 650                 655     


Pro Ile Ser Lys Val Asp Ala Ser Ala Ala Lys Ala Ile Val Val His 
            660                 665                 670         


Gly Ala Glu Leu Lys Asp Ile Gln Ser Lys Gln Leu Asp Gln Ile Leu 
        675                 680                 685             


Gln Asn His Pro Glu Ile Val Phe Ala Arg Thr Ser Pro Gln Gln Lys 
    690                 695                 700                 


Leu Ile Ile Val Glu Gly Cys Gln Arg Leu Gly Ala Val Val Ala Val 
705                 710                 715                 720 


Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile 
                725                 730                 735     


Gly Ile Ala Met Gly Ile Ser Gly Ser Asp Val Ser Lys Gln Ala Ala 
            740                 745                 750         


Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser Ile Val Thr Gly Val 
        755                 760                 765             


Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys Ser Ile Met Tyr 
    770                 775                 780                 


Thr Leu Thr Ser Asn Ile Pro Glu Ile Thr Pro Phe Leu Met Phe Ile 
785                 790                 795                 800 


Ile Leu Gly Ile Pro Leu Pro Leu Gly Thr Ile Thr Ile Leu Cys Ile 
                805                 810                 815     


Asp Leu Gly Thr Asp Met Val Pro Ala Ile Ser Leu Ala Tyr Glu Ser 
            820                 825                 830         


Ala Glu Ser Asp Ile Met Lys Arg Leu Pro Arg Asn Pro Lys Thr Asp 
        835                 840                 845             


Asn Leu Val Asn His Arg Leu Ile Gly Met Ala Tyr Gly Gln Ile Gly 
    850                 855                 860                 


Met Ile Gln Ala Leu Ala Gly Phe Phe Thr Tyr Phe Val Ile Leu Ala 
865                 870                 875                 880 


Glu Asn Gly Phe Arg Pro Val Asp Leu Leu Gly Ile Arg Leu His Trp 
                885                 890                 895     


Glu Asp Lys Tyr Leu Asn Asp Leu Glu Asp Ser Tyr Gly Gln Gln Trp 
            900                 905                 910         


Thr Tyr Glu Gln Arg Lys Val Val Glu Phe Thr Cys Gln Thr Ala Phe 
        915                 920                 925             


Phe Val Thr Ile Val Val Val Gln Trp Ala Asp Leu Ile Ile Ser Lys 
    930                 935                 940                 


Thr Arg Arg Asn Ser Leu Phe Gln Gln Gly Met Arg Asn Lys Val Leu 
945                 950                 955                 960 


Ile Phe Gly Ile Leu Glu Glu Thr Leu Leu Ala Ala Phe Leu Ser Tyr 
                965                 970                 975     


Thr Pro Gly Met Asp Val Ala Leu Arg Met Tyr Pro Leu Lys Ile Thr 
            980                 985                 990         


Trp Trp Leu Cys Ala Ile Pro Tyr  Ser Ile Leu Ile Phe  Val Tyr Asp 
        995                 1000                 1005             


Glu Ile  Arg Lys Leu Leu Ile  Arg Gln His Pro Asp  Gly Trp Val 
    1010                 1015                 1020             


Glu Arg  Glu Thr Tyr Tyr 
    1025                 


<210>  5894
<211>  629
<212>  PRT
<213>  Homo sapiens

<400>  5894

Met Asn Gln Val Thr Ile Gln Trp Asp Ala Val Ile Ala Leu Tyr Ile 
1               5                   10                  15      


Leu Phe Ser Trp Cys His Gly Gly Ile Thr Asn Ile Asn Cys Ser Gly 
            20                  25                  30          


His Ile Trp Val Glu Pro Ala Thr Ile Phe Lys Met Gly Met Asn Ile 
        35                  40                  45              


Ser Ile Tyr Cys Gln Ala Ala Ile Lys Asn Cys Gln Pro Arg Lys Leu 
    50                  55                  60                  


His Phe Tyr Lys Asn Gly Ile Lys Glu Arg Phe Gln Ile Thr Arg Ile 
65                  70                  75                  80  


Asn Lys Thr Thr Ala Arg Leu Trp Tyr Lys Asn Phe Leu Glu Pro His 
                85                  90                  95      


Ala Ser Met Tyr Cys Thr Ala Glu Cys Pro Lys His Phe Gln Glu Thr 
            100                 105                 110         


Leu Ile Cys Gly Lys Asp Ile Ser Ser Gly Tyr Pro Pro Asp Ile Pro 
        115                 120                 125             


Asp Glu Val Thr Cys Val Ile Tyr Glu Tyr Ser Gly Asn Met Thr Cys 
    130                 135                 140                 


Thr Trp Asn Ala Gly Lys Leu Thr Tyr Ile Asp Thr Lys Tyr Val Val 
145                 150                 155                 160 


His Val Lys Ser Leu Glu Thr Glu Glu Glu Gln Gln Tyr Leu Thr Ser 
                165                 170                 175     


Ser Tyr Ile Asn Ile Ser Thr Asp Ser Leu Gln Gly Gly Lys Lys Tyr 
            180                 185                 190         


Leu Val Trp Val Gln Ala Ala Asn Ala Leu Gly Met Glu Glu Ser Lys 
        195                 200                 205             


Gln Leu Gln Ile His Leu Asp Asp Ile Val Ile Pro Ser Ala Ala Val 
    210                 215                 220                 


Ile Ser Arg Ala Glu Thr Ile Asn Ala Thr Val Pro Lys Thr Ile Ile 
225                 230                 235                 240 


Tyr Trp Asp Ser Gln Thr Thr Ile Glu Lys Val Ser Cys Glu Met Arg 
                245                 250                 255     


Tyr Lys Ala Thr Thr Asn Gln Thr Trp Asn Val Lys Glu Phe Asp Thr 
            260                 265                 270         


Asn Phe Thr Tyr Val Gln Gln Ser Glu Phe Tyr Leu Glu Pro Asn Ile 
        275                 280                 285             


Lys Tyr Val Phe Gln Val Arg Cys Gln Glu Thr Gly Lys Arg Tyr Trp 
    290                 295                 300                 


Gln Pro Trp Ser Ser Leu Phe Phe His Lys Thr Pro Glu Thr Val Pro 
305                 310                 315                 320 


Gln Val Thr Ser Lys Ala Phe Gln His Asp Thr Trp Asn Ser Gly Leu 
                325                 330                 335     


Thr Val Ala Ser Ile Ser Thr Gly His Leu Thr Ser Asp Asn Arg Gly 
            340                 345                 350         


Asp Ile Gly Leu Leu Leu Gly Met Ile Val Phe Ala Val Met Leu Ser 
        355                 360                 365             


Ile Leu Ser Leu Ile Gly Ile Phe Asn Arg Ser Phe Arg Thr Gly Ile 
    370                 375                 380                 


Lys Arg Arg Ile Leu Leu Leu Ile Pro Lys Trp Leu Tyr Glu Asp Ile 
385                 390                 395                 400 


Pro Asn Met Lys Asn Ser Asn Val Val Lys Met Leu Gln Glu Asn Ser 
                405                 410                 415     


Glu Leu Met Asn Asn Asn Ser Ser Glu Gln Val Leu Tyr Val Asp Pro 
            420                 425                 430         


Met Ile Thr Glu Ile Lys Glu Ile Phe Ile Pro Glu His Lys Pro Thr 
        435                 440                 445             


Asp Tyr Lys Lys Glu Asn Thr Gly Pro Leu Glu Thr Arg Asp Tyr Pro 
    450                 455                 460                 


Gln Asn Ser Leu Phe Asp Asn Thr Thr Val Val Tyr Ile Pro Asp Leu 
465                 470                 475                 480 


Asn Thr Gly Tyr Lys Pro Gln Ile Ser Asn Phe Leu Pro Glu Gly Ser 
                485                 490                 495     


His Leu Ser Asn Asn Asn Glu Ile Thr Ser Leu Thr Leu Lys Pro Pro 
            500                 505                 510         


Val Asp Ser Leu Asp Ser Gly Asn Asn Pro Arg Leu Gln Lys His Pro 
        515                 520                 525             


Asn Phe Ala Phe Ser Val Ser Ser Val Asn Ser Leu Ser Asn Thr Ile 
    530                 535                 540                 


Phe Leu Gly Glu Leu Ser Leu Ile Leu Asn Gln Gly Glu Cys Ser Ser 
545                 550                 555                 560 


Pro Asp Ile Gln Asn Ser Val Glu Glu Glu Thr Thr Met Leu Leu Glu 
                565                 570                 575     


Asn Asp Ser Pro Ser Glu Thr Ile Pro Glu Gln Thr Leu Leu Pro Asp 
            580                 585                 590         


Glu Phe Val Ser Cys Leu Gly Ile Val Asn Glu Glu Leu Pro Ser Ile 
        595                 600                 605             


Asn Thr Tyr Phe Pro Gln Asn Ile Leu Glu Ser His Phe Asn Arg Ile 
    610                 615                 620                 


Ser Leu Leu Glu Lys 
625                 


<210>  5895
<211>  834
<212>  PRT
<213>  Homo sapiens

<400>  5895

Met Lys His Thr Leu Ala Leu Leu Ala Pro Leu Leu Gly Leu Gly Leu 
1               5                   10                  15      


Gly Leu Ala Leu Ser Gln Leu Ala Ala Gly Ala Thr Asp Cys Lys Phe 
            20                  25                  30          


Leu Gly Pro Ala Glu His Leu Thr Phe Thr Pro Ala Ala Arg Ala Arg 
        35                  40                  45              


Trp Leu Ala Pro Arg Val Arg Ala Pro Gly Leu Leu Asp Ser Leu Tyr 
    50                  55                  60                  


Gly Thr Val Arg Arg Phe Leu Ser Val Val Gln Leu Asn Pro Phe Pro 
65                  70                  75                  80  


Ser Glu Leu Val Lys Ala Leu Leu Asn Glu Leu Ala Ser Val Lys Val 
                85                  90                  95      


Asn Glu Val Val Arg Tyr Glu Ala Gly Tyr Val Val Cys Ala Val Ile 
            100                 105                 110         


Ala Gly Leu Tyr Leu Leu Leu Val Pro Thr Ala Gly Leu Cys Phe Cys 
        115                 120                 125             


Cys Cys Arg Cys His Arg Arg Cys Gly Gly Arg Val Lys Thr Glu His 
    130                 135                 140                 


Lys Ala Leu Ala Cys Glu Arg Ala Ala Leu Met Val Phe Leu Leu Leu 
145                 150                 155                 160 


Thr Thr Leu Leu Leu Leu Ile Gly Val Val Cys Ala Phe Val Thr Asn 
                165                 170                 175     


Gln Arg Thr His Glu Gln Met Gly Pro Ser Ile Glu Ala Met Pro Glu 
            180                 185                 190         


Thr Leu Leu Ser Leu Trp Gly Leu Val Ser Asp Val Pro Gln Glu Leu 
        195                 200                 205             


Gln Ala Val Ala Gln Gln Phe Ser Leu Pro Gln Glu Gln Val Ser Glu 
    210                 215                 220                 


Glu Leu Asp Gly Val Gly Val Ser Ile Gly Ser Ala Ile His Thr Gln 
225                 230                 235                 240 


Leu Arg Ser Ser Val Tyr Pro Leu Leu Ala Ala Val Gly Ser Leu Gly 
                245                 250                 255     


Gln Val Leu Gln Val Ser Val His His Leu Gln Thr Leu Asn Ala Thr 
            260                 265                 270         


Val Val Glu Leu Gln Ala Gly Gln Gln Asp Leu Glu Pro Ala Ile Arg 
        275                 280                 285             


Glu His Arg Asp Arg Leu Leu Glu Leu Leu Gln Glu Ala Arg Cys Gln 
    290                 295                 300                 


Gly Asp Cys Ala Gly Ala Leu Ser Trp Ala Arg Thr Leu Glu Leu Gly 
305                 310                 315                 320 


Ala Asp Phe Ser Gln Val Pro Ser Val Asp His Val Leu His Gln Leu 
                325                 330                 335     


Lys Gly Val Pro Glu Ala Asn Phe Ser Ser Met Val Gln Glu Glu Asn 
            340                 345                 350         


Ser Thr Phe Asn Ala Leu Pro Ala Leu Ala Ala Met Gln Thr Ser Ser 
        355                 360                 365             


Val Val Gln Glu Leu Lys Lys Ala Val Ala Gln Gln Pro Glu Gly Val 
    370                 375                 380                 


Arg Thr Leu Ala Glu Gly Phe Pro Gly Leu Glu Ala Ala Ser Arg Trp 
385                 390                 395                 400 


Ala Gln Ala Leu Gln Glu Val Glu Glu Ser Ser Arg Pro Tyr Leu Gln 
                405                 410                 415     


Glu Val Gln Arg Tyr Glu Thr Tyr Arg Trp Ile Val Gly Cys Val Leu 
            420                 425                 430         


Cys Ser Val Val Leu Phe Val Val Leu Cys Asn Leu Leu Gly Leu Asn 
        435                 440                 445             


Leu Gly Ile Trp Gly Leu Ser Ala Arg Asp Asp Pro Ser His Pro Glu 
    450                 455                 460                 


Ala Lys Gly Glu Ala Gly Ala Arg Phe Leu Met Ala Gly Val Gly Leu 
465                 470                 475                 480 


Ser Phe Leu Phe Ala Ala Pro Leu Ile Leu Leu Val Phe Ala Thr Phe 
                485                 490                 495     


Leu Val Gly Gly Asn Val Gln Thr Leu Val Cys Gln Ser Trp Glu Asn 
            500                 505                 510         


Gly Glu Leu Phe Glu Phe Ala Asp Thr Pro Gly Asn Leu Pro Pro Ser 
        515                 520                 525             


Met Asn Leu Ser Gln Leu Leu Gly Leu Arg Lys Asn Ile Ser Ile His 
    530                 535                 540                 


Gln Ala Tyr Gln Gln Cys Lys Glu Gly Ala Ala Leu Trp Thr Val Leu 
545                 550                 555                 560 


Gln Leu Asn Asp Ser Tyr Asp Leu Glu Glu His Leu Asp Ile Asn Gln 
                565                 570                 575     


Tyr Thr Asn Lys Leu Arg Gln Glu Leu Gln Ser Leu Lys Val Asp Thr 
            580                 585                 590         


Gln Ser Leu Asp Leu Leu Ser Ser Ala Ala Arg Arg Asp Leu Glu Ala 
        595                 600                 605             


Leu Gln Ser Ser Gly Leu Gln Arg Ile His Tyr Pro Asp Phe Leu Val 
    610                 615                 620                 


Gln Ile Gln Arg Pro Val Val Lys Thr Ser Met Glu Gln Leu Ala Gln 
625                 630                 635                 640 


Glu Leu Gln Gly Leu Ala Gln Ala Gln Asp Asn Ser Val Leu Gly Gln 
                645                 650                 655     


Arg Leu Gln Glu Glu Ala Gln Gly Leu Arg Asn Leu His Gln Glu Lys 
            660                 665                 670         


Val Val Pro Gln Gln Ser Leu Val Ala Lys Leu Asn Leu Ser Val Arg 
        675                 680                 685             


Ala Leu Glu Ser Ser Ala Pro Asn Leu Gln Leu Glu Thr Ser Asp Val 
    690                 695                 700                 


Leu Ala Asn Val Thr Tyr Leu Lys Gly Glu Leu Pro Ala Trp Ala Ala 
705                 710                 715                 720 


Arg Ile Leu Arg Asn Val Ser Glu Cys Phe Leu Ala Arg Glu Met Gly 
                725                 730                 735     


Tyr Phe Ser Gln Tyr Val Ala Trp Val Arg Glu Glu Val Thr Gln Arg 
            740                 745                 750         


Ile Ala Thr Cys Gln Pro Leu Ser Gly Ala Leu Asp Asn Ser Arg Val 
        755                 760                 765             


Ile Leu Cys Asp Met Met Ala Asp Pro Trp Asn Ala Phe Trp Phe Cys 
    770                 775                 780                 


Leu Ala Trp Cys Thr Phe Phe Leu Ile Pro Ser Ile Ile Phe Ala Val 
785                 790                 795                 800 


Lys Thr Ser Lys Tyr Phe Arg Pro Ile Arg Lys Arg Leu Ser Ser Thr 
                805                 810                 815     


Ser Ser Glu Glu Thr Gln Leu Phe His Ile Pro Arg Val Thr Ser Leu 
            820                 825                 830         


Lys Leu 
        


<210>  5896
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  5896

Met Ser Arg Ser Pro Leu Asn Pro Ser Gln Leu Arg Ser Val Gly Ser 
1               5                   10                  15      


Gln Asp Ala Leu Ala Pro Leu Pro Pro Pro Ala Pro Gln Asn Pro Ser 
            20                  25                  30          


Thr His Ser Trp Asp Pro Leu Cys Gly Ser Leu Pro Trp Gly Leu Ser 
        35                  40                  45              


Cys Leu Leu Ala Leu Gln His Val Leu Val Met Ala Ser Leu Leu Cys 
    50                  55                  60                  


Val Ser His Leu Leu Leu Leu Cys Ser Leu Ser Pro Gly Gly Leu Ser 
65                  70                  75                  80  


Tyr Ser Pro Ser Gln Leu Leu Ala Ser Ser Phe Phe Ser Cys Gly Met 
                85                  90                  95      


Ser Thr Ile Leu Gln Thr Trp Met Gly Ser Arg Leu Pro Leu Val Gln 
            100                 105                 110         


Ala Pro Ser Leu Glu Phe Leu Ile Pro Ala Leu Val Leu Thr Ser Gln 
        115                 120                 125             


Lys Leu Pro Arg Ala Ile Gln Thr Pro Gly Asn Ser Ser Leu Met Leu 
    130                 135                 140                 


His Leu Cys Arg Gly Pro Ser Cys His Gly Leu Gly His Trp Asn Thr 
145                 150                 155                 160 


Ser Leu Gln Glu Val Ser Gly Ala Val Val Val Ser Gly Leu Leu Gln 
                165                 170                 175     


Gly Met Met Gly Leu Leu Gly Ser Pro Gly His Val Phe Pro His Cys 
            180                 185                 190         


Gly Pro Leu Val Leu Ala Pro Ser Leu Val Val Ala Gly Leu Ser Ala 
        195                 200                 205             


His Arg Glu Val Ala Gln Phe Cys Phe Thr His Trp Gly Leu Ala Leu 
    210                 215                 220                 


Leu Thr Trp Ala Pro Ala Ser Phe Met Cys Ala Pro Gly Gly Glu Leu 
225                 230                 235                 240 


Gln Arg His Gln Leu Thr Leu Leu Ser Leu Ser Ser Gly Ser Phe Arg 
                245                 250                 255     


Asn Cys Leu Pro Pro Pro Arg His His Gly Phe Gly Cys Leu Thr Gln 
            260                 265                 270         


Ala Gly Ser Gln Gln Val Ala His Leu Val Gly Leu Leu Cys Val Gly 
        275                 280                 285             


Leu Gly Leu Ser Pro Arg Leu Ala Gln Leu Leu Thr Thr Ile Pro Leu 
    290                 295                 300                 


Pro Val Val Gly Gly Val Leu Gly Val Thr Gln Ala Val Val Leu Ser 
305                 310                 315                 320 


Ala Gly Phe Ser Ser Phe Tyr Leu Ala Asp Ile Asp Ser Gly Arg Asn 
                325                 330                 335     


Ile Phe Ile Val Gly Phe Ser Ile Phe Met Ala Leu Leu Leu Pro Arg 
            340                 345                 350         


Trp Phe Arg Glu Ala Pro Val Leu Phe Ser Thr Gly Trp Ser Pro Leu 
        355                 360                 365             


Asp Val Leu Leu His Ser Leu Leu Thr Gln Pro Ile Phe Leu Ala Gly 
    370                 375                 380                 


Leu Ser Gly Phe Leu Leu Glu Asn Thr Ile Pro Gly Thr Gln Leu Glu 
385                 390                 395                 400 


Arg Gly Leu Gly Gln Gly Leu Pro Ser Pro Phe Thr Ala Gln Glu Ala 
                405                 410                 415     


Arg Met Pro Gln Lys Pro Arg Glu Lys Ala Ala Gln Val Tyr Arg Leu 
            420                 425                 430         


Pro Phe Pro Ile Gln Asn Leu Cys Pro Cys Ile Pro Gln Pro Leu His 
        435                 440                 445             


Cys Leu Cys Pro Leu Pro Glu Asp Pro Gly Asp Glu Glu Gly Gly Ser 
    450                 455                 460                 


Ser Glu Pro Glu Glu Met Ala Asp Leu Leu Pro Gly Ser Gly Glu Pro 
465                 470                 475                 480 


Cys Pro Glu Ser Ser Arg Glu Gly Phe Arg Ser Gln Lys 
                485                 490             


<210>  5897
<211>  573
<212>  PRT
<213>  Homo sapiens

<400>  5897

Met Gly Lys Cys Leu Ser Cys Cys Lys Glu Asp Gln Ser Phe Gln Arg 
1               5                   10                  15      


Cys Ser Pro Glu Asp Gln Val Ser Thr Asp Ala Gln His Arg Gly Ala 
            20                  25                  30          


Ser Ser Ile Ser Gln Pro Ser Ile Ser Leu Gly His Lys Thr Ser Tyr 
        35                  40                  45              


Ser Pro Val Thr His Lys Val Asn Ala Ala Lys Ala Ser Arg Arg Leu 
    50                  55                  60                  


Leu Ser Val Ser Ser Pro Ser Phe Ser Glu Arg Arg Tyr Ser Leu Phe 
65                  70                  75                  80  


Val Gly Phe Gln Lys Arg Asn Ala Ser Pro Tyr Trp Gln Gln Ser Arg 
                85                  90                  95      


Ala Asn Phe Asp Ser Glu Glu Asp Thr Gly Phe Thr Asp Ile Lys Ser 
            100                 105                 110         


Ser Ser Asp His Cys Gly Ser Phe Ile Ser Arg Arg Arg Arg Phe Ser 
        115                 120                 125             


Ser Arg Lys Leu Ser Ile Val Ser Tyr Tyr Lys Ser Ala Ile Phe Phe 
    130                 135                 140                 


Asp Pro Gln Ala Ser Gly Gln Asn Val Phe Asn Leu Asn Glu Ile Glu 
145                 150                 155                 160 


Ile Phe Ser Lys Thr Ser Ser Asn Thr Asp Ala Lys Lys His Ile Thr 
                165                 170                 175     


Ile Ser Ala Pro Glu Tyr Asn Thr Lys Asn Phe Lys Asn Phe Glu Thr 
            180                 185                 190         


Asn Thr Thr Ser Pro Ala Phe Gly Asn Thr Ile Asp Thr Ala Ser Tyr 
        195                 200                 205             


Gln Gln Ser Thr Ser Ser Phe Phe Ser Leu Ala Ser Asp Ile Ser Ser 
    210                 215                 220                 


Pro Asp Gln Gln Asn Gly Ile Ala Asn Asp Ile Gln Gln Arg Gly Gln 
225                 230                 235                 240 


Leu Cys Lys Asp Leu Lys Asp Phe Leu His Pro Arg Pro Glu Ser Tyr 
                245                 250                 255     


Ser Thr Asp His Ser Pro Ile Met Ile Pro Gln His Pro Ser Gln Ser 
            260                 265                 270         


Gly Thr Phe Pro Phe Leu His Lys Ala Gly Phe Ser Ser Ser Tyr Lys 
        275                 280                 285             


Asn Ser Gly Cys Phe Ile Pro Pro Gln Ser Glu Leu Thr Ser Gly Leu 
    290                 295                 300                 


Phe Glu Asp Glu Asp Phe Ala Val Leu Phe Gln Asp Glu Asp Arg Ser 
305                 310                 315                 320 


Ser Pro Ile Glu Ile Pro Lys Ile Arg Tyr Ile Thr Ala Asn Thr Asp 
                325                 330                 335     


Thr Glu Glu Gln Ser Phe Pro Val Pro Lys Ala Phe Asn Thr Arg Val 
            340                 345                 350         


Glu Glu Leu Asn Leu Asp Val Leu Leu Gln Lys Val Asp His Leu Arg 
        355                 360                 365             


Met Ser Glu Ser Gly Lys Ser Glu Ser Phe Glu Leu Leu Arg Asp His 
    370                 375                 380                 


Lys Glu Lys Phe Arg Asp Glu Ile Glu Phe Met Trp Arg Phe Ala Arg 
385                 390                 395                 400 


Ala Tyr Gly Asp Met Tyr Glu Leu Ser Thr Asn Thr Gln Glu Lys Lys 
                405                 410                 415     


His Tyr Ala Asn Ile Gly Lys Thr Leu Ser Glu Arg Ala Ile Asn Arg 
            420                 425                 430         


Ala Pro Met Asn Gly His Cys His Leu Trp Tyr Ala Val Leu Cys Gly 
        435                 440                 445             


Tyr Val Ser Glu Phe Glu Gly Leu Gln Asn Lys Ile Asn Tyr Gly His 
    450                 455                 460                 


Leu Phe Lys Glu His Leu Asp Ile Ala Ile Lys Leu Leu Pro Glu Glu 
465                 470                 475                 480 


Pro Phe Leu Tyr Tyr Leu Lys Gly Arg Tyr Cys Tyr Thr Val Ser Lys 
                485                 490                 495     


Leu Ser Trp Ile Glu Lys Lys Met Ala Ala Thr Leu Phe Gly Lys Ile 
            500                 505                 510         


Pro Ser Ser Thr Val Gln Glu Ala Leu His Asn Phe Leu Lys Ala Glu 
        515                 520                 525             


Glu Leu Cys Pro Gly Tyr Ser Asn Pro Asn Tyr Met Tyr Leu Ala Lys 
    530                 535                 540                 


Cys Tyr Thr Asp Leu Glu Glu Asn Gln Asn Ala Leu Lys Phe Cys Asn 
545                 550                 555                 560 


Leu Ala Leu Leu Leu Pro Thr Val Thr Lys Glu Glu Leu 
                565                 570             


<210>  5898
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  5898

Met Gln Thr Phe Thr Met Val Leu Glu Glu Ile Trp Thr Ser Leu Phe 
1               5                   10                  15      


Met Trp Phe Phe Tyr Ala Leu Ile Pro Cys Leu Leu Thr Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Pro Ala Pro Gln Asn Leu Ser Val Leu Ser Thr Asn Met 
        35                  40                  45              


Lys His Leu Leu Met Trp Ser Pro Val Ile Ala Pro Gly Glu Thr Val 
    50                  55                  60                  


Tyr Tyr Ser Val Glu Tyr Gln Gly Glu Tyr Glu Ser Leu Tyr Thr Ser 
65                  70                  75                  80  


His Ile Trp Ile Pro Ser Ser Trp Cys Ser Leu Thr Glu Gly Pro Glu 
                85                  90                  95      


Cys Asp Val Thr Asp Asp Ile Thr Ala Thr Val Pro Tyr Asn Leu Arg 
            100                 105                 110         


Val Arg Ala Thr Leu Gly Ser Gln Thr Ser Ala Trp Ser Ile Leu Lys 
        115                 120                 125             


His Pro Phe Asn Arg Asn Ser Thr Ile Leu Thr Arg Pro Gly Met Glu 
    130                 135                 140                 


Ile Thr Lys Asp Gly Phe His Leu Val Ile Glu Leu Glu Asp Leu Gly 
145                 150                 155                 160 


Pro Gln Phe Glu Phe Leu Val Ala Tyr Trp Arg Arg Glu Pro Gly Ala 
                165                 170                 175     


Glu Glu His Val Lys Met Val Arg Ser Gly Gly Ile Pro Val His Leu 
            180                 185                 190         


Glu Thr Met Glu Pro Gly Ala Ala Tyr Cys Val Lys Ala Gln Thr Phe 
        195                 200                 205             


Val Lys Ala Ile Gly Arg Tyr Ser Ala Phe Ser Gln Thr Glu Cys Val 
    210                 215                 220                 


Glu Val Gln Gly Glu Ala Ile Pro Leu Val Leu Ala Leu Phe Ala Phe 
225                 230                 235                 240 


Val Gly Phe Met Leu Ile Leu Val Val Val Pro Leu Phe Val Trp Lys 
                245                 250                 255     


Met Gly Arg Leu Leu Gln Tyr Ser Cys Cys Pro Val Val Val Leu Pro 
            260                 265                 270         


Asp Thr Leu Lys Ile Thr Asn Ser Pro Gln Lys Leu Ile Ser Cys Arg 
        275                 280                 285             


Arg Glu Glu Val Asp Ala Cys Ala Thr Ala Val Met Ser Pro Glu Glu 
    290                 295                 300                 


Leu Leu Arg Ala Trp Ile Ser 
305                 310     


<210>  5899
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  5899

Met Val Lys Cys Cys Ser Ala Ile Gly Cys Ala Ser Arg Cys Leu Pro 
1               5                   10                  15      


Asn Ser Lys Leu Lys Gly Leu Thr Phe His Val Phe Pro Thr Asp Glu 
            20                  25                  30          


Asn Ile Lys Arg Lys Trp Val Leu Ala Met Lys Arg Leu Asp Val Asn 
        35                  40                  45              


Ala Ala Gly Ile Trp Glu Pro Lys Lys Gly Asp Val Leu Cys Ser Arg 
    50                  55                  60                  


His Phe Lys Lys Thr Asp Phe Asp Arg Ser Ala Pro Asn Ile Lys Leu 
65                  70                  75                  80  


Lys Pro Gly Val Ile Pro Ser Ile Phe Asp Ser Pro Tyr His Leu Gln 
                85                  90                  95      


Gly Lys Arg Glu Lys Leu His Cys Arg Lys Asn Phe Thr Leu Lys Thr 
            100                 105                 110         


Val Pro Ala Thr Asn Tyr Asn His His Leu Val Gly Ala Ser Ser Cys 
        115                 120                 125             


Ile Glu Glu Phe Gln Ser Gln Phe Ile Phe Glu His Ser Tyr Ser Val 
    130                 135                 140                 


Met Asp Ser Pro Lys Lys Leu Lys His Lys Leu Asp His Val Ile Gly 
145                 150                 155                 160 


Glu Leu Glu Asp Thr Lys Glu Ser Leu Arg Asn Val Leu Asp Arg Glu 
                165                 170                 175     


Lys Arg Phe Gln Lys Ser Leu Arg Lys Thr Ile Arg Glu Leu Lys Asp 
            180                 185                 190         


Glu Cys Leu Ile Ser Gln Glu Thr Ala Asn Arg Leu Asp Thr Phe Cys 
        195                 200                 205             


Trp Asp Cys Cys Gln Glu Ser Ile Glu Gln Asp Tyr Ile Ser 
    210                 215                 220         


<210>  5900
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  5900

Met Ser Asn Asp Gly Arg Ser Arg Asn Arg Asp Arg Arg Tyr Asp Glu 
1               5                   10                  15      


Val Pro Ser Asp Leu Pro Tyr Gln Asp Thr Thr Ile Arg Thr His Pro 
            20                  25                  30          


Thr Leu His Asp Ser Glu Arg Ala Val Ser Ala Asp Pro Leu Pro Pro 
        35                  40                  45              


Pro Pro Leu Pro Leu Gln Pro Pro Phe Gly Pro Asp Phe Tyr Ser Ser 
    50                  55                  60                  


Asp Thr Glu Glu Pro Ala Ile Ala Pro Asp Leu Lys Pro Val Arg Arg 
65                  70                  75                  80  


Phe Val Pro Asp Ser Trp Lys Asn Phe Phe Arg Gly Lys Lys Lys Asp 
                85                  90                  95      


Pro Glu Trp Asp Lys Pro Val Ser Asp Ile Arg Tyr Ile Ser Asp Gly 
            100                 105                 110         


Val Glu Cys Ser Pro Pro Ala Ser Pro Ala Arg Pro Asn His Arg Ser 
        115                 120                 125             


Pro Leu Asn Ser Cys Lys Asp Pro Tyr Gly Gly Ser Glu Gly Thr Phe 
    130                 135                 140                 


Ser Ser Arg Lys Glu Ala Asp Ala Val Phe Pro Arg Asp Pro Tyr Gly 
145                 150                 155                 160 


Ser Leu Asp Arg His Thr Gln Thr Val Arg Thr Tyr Ser Glu Lys Val 
                165                 170                 175     


Glu Glu Tyr Asn Leu Arg Tyr Ser Tyr Met Lys Ser Trp Ala Gly Leu 
            180                 185                 190         


Leu Arg Ile Leu Gly Val Val Glu Leu Leu Leu Gly Ala Gly Val Phe 
        195                 200                 205             


Ala Cys Val Thr Ala Tyr Ile His Lys Asp Ser Glu Trp Tyr Asn Leu 
    210                 215                 220                 


Phe Gly Tyr Ser Gln Pro Tyr Gly Met Gly Gly Val Gly Gly Leu Gly 
225                 230                 235                 240 


Ser Met Tyr Gly Gly Tyr Tyr Tyr Thr Gly Pro Lys Thr Pro Phe Val 
                245                 250                 255     


Leu Val Val Ala Gly Leu Ala Trp Ile Thr Thr Ile Ile Ile Leu Val 
            260                 265                 270         


Leu Gly Met Ser Met Tyr Tyr Arg Thr Ile Leu Leu Asp Ser Asn Trp 
        275                 280                 285             


Trp Pro Leu Thr Glu Phe Gly Ile Asn Val Ala Leu Phe Ile Leu Tyr 
    290                 295                 300                 


Met Ala Ala Ala Ile Val Tyr Val Asn Asp Thr Asn Arg Gly Gly Leu 
305                 310                 315                 320 


Cys Tyr Tyr Pro Leu Phe Asn Thr Pro Val Asn Ala Val Phe Cys Arg 
                325                 330                 335     


Val Glu Gly Gly Gln Ile Ala Ala Met Ile Phe Leu Phe Val Thr Met 
            340                 345                 350         


Ile Val Tyr Leu Ile Ser Ala Leu Val Cys Leu Lys Leu Trp Arg His 
        355                 360                 365             


Glu Ala Ala Arg Arg His Arg Glu Tyr Met Glu Gln Gln Glu Ile Asn 
    370                 375                 380                 


Glu Pro Ser Leu Ser Ser Lys Arg Lys Met Cys Glu Met Ala Thr Ser 
385                 390                 395                 400 


Gly Asp Arg Gln Arg Asp Ser Glu Val Asn Phe Lys Glu Leu Arg Thr 
                405                 410                 415     


Ala Lys Met Lys Pro Glu Leu Leu Ser Gly His Ile Pro Pro Gly His 
            420                 425                 430         


Ile Pro Lys Pro Ile Val Met Pro Asp Tyr Val Ala Lys Tyr Pro Val 
        435                 440                 445             


Ile Gln Thr Asp Asp Glu Arg Glu Arg Tyr Lys Ala Val Phe Gln Asp 
    450                 455                 460                 


Gln Phe Ser Glu Tyr Lys Glu Leu Ser Ala Glu Val Gln Ala Val Leu 
465                 470                 475                 480 


Arg Lys Phe Asp Glu Leu Asp Ala Val Met Ser Arg Leu Pro His His 
                485                 490                 495     


Ser Glu Ser Arg Gln Glu His Glu Arg Ile Ser Arg Ile His Glu Glu 
            500                 505                 510         


Phe Lys Lys Lys Lys Asn Asp Pro Thr Phe Leu Glu Lys Lys Glu Arg 
        515                 520                 525             


Cys Asp Tyr Leu Lys Asn Lys Leu Ser His Ile Lys Gln Arg Ile Gln 
    530                 535                 540                 


Glu Tyr Asp Lys Val Met Asn Trp Asp Val Gln Gly Tyr Ser 
545                 550                 555             


<210>  5901
<211>  691
<212>  PRT
<213>  Homo sapiens

<400>  5901

Met Met Arg Asn His Arg Ile Ala Ser Ser Leu Cys Gly Asp Gln Val 
1               5                   10                  15      


Phe Ser Lys Lys Lys Lys Lys Lys Lys Lys Asn Asn Met Ala Ala Lys 
            20                  25                  30          


Glu Lys Leu Glu Ala Val Leu Asn Val Ala Leu Arg Val Pro Ser Ile 
        35                  40                  45              


Met Leu Leu Asp Val Leu Tyr Arg Trp Asp Val Ser Ser Phe Phe Gln 
    50                  55                  60                  


Gln Ile Gln Arg Ser Ser Leu Ser Asn Asn Pro Leu Phe Gln Tyr Lys 
65                  70                  75                  80  


Tyr Leu Ala Leu Asn Met His Tyr Val Gly Tyr Ile Leu Ser Val Val 
                85                  90                  95      


Leu Leu Thr Leu Pro Arg Gln His Leu Val Gln Leu Tyr Leu Tyr Phe 
            100                 105                 110         


Leu Thr Ala Leu Leu Leu Tyr Ala Gly His Gln Ile Ser Arg Asp Tyr 
        115                 120                 125             


Val Arg Ser Glu Leu Glu Phe Ala Tyr Glu Gly Pro Met Tyr Leu Glu 
    130                 135                 140                 


Pro Leu Ser Met Asn Arg Phe Thr Thr Ala Leu Ile Gly Gln Leu Val 
145                 150                 155                 160 


Val Cys Thr Leu Cys Ser Cys Val Met Lys Thr Lys Gln Ile Trp Leu 
                165                 170                 175     


Phe Ser Ala His Met Leu Pro Leu Leu Ala Arg Leu Cys Leu Val Pro 
            180                 185                 190         


Leu Glu Thr Ile Val Ile Ile Asn Lys Phe Ala Met Ile Phe Thr Gly 
        195                 200                 205             


Leu Glu Val Leu Tyr Phe Leu Gly Ser Asn Leu Leu Val Pro Tyr Asn 
    210                 215                 220                 


Leu Ala Lys Ser Ala Tyr Arg Glu Leu Val Gln Val Val Glu Val Tyr 
225                 230                 235                 240 


Gly Leu Leu Ala Leu Gly Met Ser Leu Trp Asn Gln Leu Val Val Pro 
                245                 250                 255     


Val Leu Phe Met Val Phe Trp Leu Val Leu Phe Ala Leu Gln Ile Tyr 
            260                 265                 270         


Ser Tyr Phe Ser Thr Arg Asp Gln Pro Ala Ser Arg Glu Arg Leu Leu 
        275                 280                 285             


Phe Leu Phe Leu Thr Ser Ile Ala Glu Cys Cys Ser Thr Pro Tyr Ser 
    290                 295                 300                 


Leu Leu Gly Leu Val Phe Thr Val Ser Phe Val Ala Leu Gly Val Leu 
305                 310                 315                 320 


Thr Leu Cys Lys Phe Tyr Leu Gln Gly Tyr Arg Ala Phe Met Asn Asp 
                325                 330                 335     


Pro Ala Met Asn Arg Gly Met Thr Glu Gly Val Thr Leu Leu Ile Leu 
            340                 345                 350         


Ala Val Gln Thr Gly Leu Ile Glu Leu Gln Val Val His Arg Ala Phe 
        355                 360                 365             


Leu Leu Ser Ile Ile Leu Phe Ile Val Val Ala Ser Ile Leu Gln Ser 
    370                 375                 380                 


Met Leu Glu Ile Ala Asp Pro Ile Val Leu Ala Leu Gly Ala Ser Arg 
385                 390                 395                 400 


Asp Lys Ser Leu Trp Lys His Phe Arg Ala Val Ser Leu Cys Leu Phe 
                405                 410                 415     


Leu Leu Val Phe Pro Ala Tyr Met Ala Tyr Met Ile Cys Gln Phe Phe 
            420                 425                 430         


His Met Asp Phe Trp Leu Leu Ile Ile Ile Ser Ser Ser Ile Leu Thr 
        435                 440                 445             


Ser Leu Gln Val Leu Gly Thr Leu Phe Ile Tyr Val Leu Phe Met Val 
    450                 455                 460                 


Glu Glu Phe Arg Lys Glu Pro Val Glu Asn Met Asp Asp Val Ile Tyr 
465                 470                 475                 480 


Tyr Val Asn Gly Thr Tyr Arg Leu Leu Glu Phe Leu Val Ala Leu Cys 
                485                 490                 495     


Val Val Ala Tyr Gly Val Ser Glu Thr Ile Phe Gly Glu Trp Thr Val 
            500                 505                 510         


Met Gly Ser Met Ile Ile Phe Ile His Ser Tyr Tyr Asn Val Trp Leu 
        515                 520                 525             


Arg Ala Gln Leu Gly Trp Lys Ser Phe Leu Leu Arg Arg Asp Ala Val 
    530                 535                 540                 


Asn Lys Ile Lys Ser Leu Pro Ile Ala Thr Lys Glu Gln Leu Glu Lys 
545                 550                 555                 560 


His Asn Asp Ile Cys Ala Ile Cys Tyr Gln Asp Met Lys Ser Ala Val 
                565                 570                 575     


Ile Thr Pro Cys Ser His Phe Phe His Ala Gly Cys Leu Lys Lys Trp 
            580                 585                 590         


Leu Tyr Val Gln Glu Thr Cys Pro Leu Cys His Cys His Leu Lys Asn 
        595                 600                 605             


Ser Ser Gln Leu Pro Gly Leu Gly Thr Glu Pro Val Leu Gln Pro His 
    610                 615                 620                 


Ala Gly Ala Glu Gln Asn Val Met Phe Gln Glu Gly Thr Glu Pro Pro 
625                 630                 635                 640 


Gly Gln Glu His Thr Pro Gly Thr Arg Ile Gln Glu Gly Ser Arg Asp 
                645                 650                 655     


Asn Asn Glu Tyr Ile Ala Arg Arg Pro Asp Asn Gln Glu Gly Ala Phe 
            660                 665                 670         


Asp Pro Lys Glu Tyr Pro His Ser Ala Lys Asp Glu Ala His Pro Val 
        675                 680                 685             


Glu Ser Ala 
    690     


<210>  5902
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  5902

Met Tyr Gly Lys Ser Ser Thr Arg Ala Val Leu Leu Leu Leu Gly Ile 
1               5                   10                  15      


Gln Leu Thr Ala Leu Trp Pro Ile Ala Ala Val Glu Ile Tyr Thr Ser 
            20                  25                  30          


Arg Val Leu Glu Ala Val Asn Gly Thr Asp Ala Arg Leu Lys Cys Thr 
        35                  40                  45              


Phe Ser Ser Phe Ala Pro Val Gly Asp Ala Leu Thr Val Thr Trp Asn 
    50                  55                  60                  


Phe Arg Pro Leu Asp Gly Gly Pro Glu Gln Phe Val Phe Tyr Tyr His 
65                  70                  75                  80  


Ile Asp Pro Phe Gln Pro Met Ser Gly Arg Phe Lys Asp Arg Val Ser 
                85                  90                  95      


Trp Asp Gly Asn Pro Glu Arg Tyr Asp Ala Ser Ile Leu Leu Trp Lys 
            100                 105                 110         


Leu Gln Phe Asp Asp Asn Gly Thr Tyr Thr Cys Gln Val Lys Asn Pro 
        115                 120                 125             


Pro Asp Val Asp Gly Val Ile Gly Glu Ile Arg Leu Ser Val Val His 
    130                 135                 140                 


Thr Val Arg Phe Ser Glu Ile His Phe Leu Ala Leu Ala Ile Gly Ser 
145                 150                 155                 160 


Ala Cys Ala Leu Met Ile Ile Ile Val Ile Val Val Val Leu Phe Gln 
                165                 170                 175     


His Tyr Arg Lys Lys Arg Trp Ala Glu Arg Ala His Lys Val Val Glu 
            180                 185                 190         


Ile Lys Ser Lys Glu Glu Glu Arg Leu Asn Gln Glu Lys Lys Val Ser 
        195                 200                 205             


Val Tyr Leu Glu Asp Thr Asp 
    210                 215 


<210>  5903
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  5903

Met Ala Ala Gln Asn Gly Asn Thr Ser Phe Thr Pro Asn Phe Asn Pro 
1               5                   10                  15      


Pro Gln Asp His Ala Ser Ser Leu Ser Phe Asn Phe Ser Tyr Gly Asp 
            20                  25                  30          


Tyr Asp Leu Pro Met Asp Glu Asp Glu Asp Met Thr Lys Thr Arg Thr 
        35                  40                  45              


Phe Phe Ala Ala Lys Ile Val Ile Gly Ile Ala Leu Ala Gly Ile Met 
    50                  55                  60                  


Leu Val Cys Gly Ile Gly Asn Phe Val Phe Ile Ala Ala Leu Thr Arg 
65                  70                  75                  80  


Tyr Lys Lys Leu Arg Asn Leu Thr Asn Leu Leu Ile Ala Asn Leu Ala 
                85                  90                  95      


Ile Ser Asp Phe Leu Val Ala Ile Ile Cys Cys Pro Phe Glu Met Asp 
            100                 105                 110         


Tyr Tyr Val Val Arg Gln Leu Ser Trp Glu His Gly His Val Leu Cys 
        115                 120                 125             


Ala Ser Val Asn Tyr Leu Arg Thr Val Ser Leu Tyr Val Ser Thr Asn 
    130                 135                 140                 


Ala Leu Leu Ala Ile Ala Ile Asp Arg Tyr Leu Ala Ile Val His Pro 
145                 150                 155                 160 


Leu Lys Pro Arg Met Asn Tyr Gln Thr Ala Ser Phe Leu Ile Ala Leu 
                165                 170                 175     


Val Trp Met Val Ser Ile Leu Ile Ala Ile Pro Ser Ala Tyr Phe Ala 
            180                 185                 190         


Thr Glu Thr Val Leu Phe Ile Val Lys Ser Gln Glu Lys Ile Phe Cys 
        195                 200                 205             


Gly Gln Ile Trp Pro Val Asp Gln Gln Leu Tyr Tyr Lys Ser Tyr Phe 
    210                 215                 220                 


Leu Phe Ile Phe Gly Val Glu Phe Val Gly Pro Val Val Thr Met Thr 
225                 230                 235                 240 


Leu Cys Tyr Ala Arg Ile Ser Arg Glu Leu Trp Phe Lys Ala Val Pro 
                245                 250                 255     


Gly Phe Gln Thr Glu Gln Ile Arg Lys Arg Leu Arg Cys Arg Arg Lys 
            260                 265                 270         


Thr Val Leu Val Leu Met Cys Ile Leu Thr Ala Tyr Val Leu Cys Trp 
        275                 280                 285             


Ala Pro Phe Tyr Gly Phe Thr Ile Val Arg Asp Phe Phe Pro Thr Val 
    290                 295                 300                 


Phe Val Lys Glu Lys His Tyr Leu Thr Ala Phe Tyr Val Val Glu Cys 
305                 310                 315                 320 


Ile Ala Met Ser Asn Ser Met Ile Asn Thr Val Cys Phe Val Thr Val 
                325                 330                 335     


Lys Asn Asn Thr Met Lys Tyr Phe Lys Lys Met Met Leu Leu His Trp 
            340                 345                 350         


Arg Pro Ser Gln Arg Gly Ser Lys Ser Ser Ala Asp Leu Asp Leu Arg 
        355                 360                 365             


Thr Asn Gly Val Pro Thr Thr Glu Glu Val Asp Cys Ile Arg Leu Lys 
    370                 375                 380                 


<210>  5904
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  5904

Met Ser Pro Ser Gly Arg Leu Cys Leu Leu Thr Ile Val Gly Leu Ile 
1               5                   10                  15      


Leu Pro Thr Arg Gly Gln Thr Leu Lys Asp Thr Thr Ser Ser Ser Ser 
            20                  25                  30          


Ala Asp Ser Thr Ile Met Asp Ile Gln Val Pro Thr Arg Ala Pro Asp 
        35                  40                  45              


Ala Val Tyr Thr Glu Leu Gln Pro Thr Ser Pro Thr Pro Thr Trp Pro 
    50                  55                  60                  


Ala Asp Glu Thr Pro Gln Pro Gln Thr Gln Thr Gln Gln Leu Glu Gly 
65                  70                  75                  80  


Thr Asp Gly Pro Leu Val Thr Asp Pro Glu Thr His Lys Ser Thr Lys 
                85                  90                  95      


Ala Ala His Pro Thr Asp Asp Thr Thr Thr Leu Ser Glu Arg Pro Ser 
            100                 105                 110         


Pro Ser Thr Asp Val Gln Thr Asp Pro Gln Thr Leu Lys Pro Ser Gly 
        115                 120                 125             


Phe His Glu Asp Asp Pro Phe Phe Tyr Asp Glu His Thr Leu Arg Lys 
    130                 135                 140                 


Arg Gly Leu Leu Val Ala Ala Val Leu Phe Ile Thr Gly Ile Ile Ile 
145                 150                 155                 160 


Leu Thr Ser Gly Lys Cys Arg Gln Leu Ser Arg Leu Cys Arg Asn Arg 
                165                 170                 175     


Cys Arg 
        


<210>  5905
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  5905

Met Gly Ser Arg Val Ser Arg Glu Asp Phe Glu Trp Val Tyr Thr Asp 
1               5                   10                  15      


Gln Pro His Ala Asp Arg Arg Arg Glu Ile Leu Ala Lys Tyr Pro Glu 
            20                  25                  30          


Ile Lys Ser Leu Met Lys Pro Asp Pro Asn Leu Ile Trp Ile Ile Ile 
        35                  40                  45              


Met Met Val Leu Thr Gln Leu Gly Ala Phe Tyr Ile Val Lys Asp Leu 
    50                  55                  60                  


Asp Trp Lys Trp Val Ile Phe Gly Ala Tyr Ala Phe Gly Ser Cys Ile 
65                  70                  75                  80  


Asn His Ser Met Thr Leu Ala Ile His Glu Ile Ala His Asn Ala Ala 
                85                  90                  95      


Phe Gly Asn Cys Lys Ala Met Trp Asn Arg Trp Phe Gly Met Phe Ala 
            100                 105                 110         


Asn Leu Pro Ile Gly Ile Pro Tyr Ser Ile Ser Phe Lys Arg Tyr His 
        115                 120                 125             


Met Asp His His Arg Tyr Leu Gly Ala Asp Gly Val Asp Val Asp Ile 
    130                 135                 140                 


Pro Thr Asp Phe Glu Gly Trp Phe Phe Cys Thr Ala Phe Arg Lys Phe 
145                 150                 155                 160 


Ile Trp Val Ile Leu Gln Pro Leu Phe Tyr Ala Phe Arg Pro Leu Phe 
                165                 170                 175     


Ile Asn Pro Lys Pro Ile Thr Tyr Leu Glu Val Ile Asn Thr Val Ala 
            180                 185                 190         


Gln Val Thr Phe Asp Ile Leu Ile Tyr Tyr Phe Leu Gly Ile Lys Ser 
        195                 200                 205             


Leu Val Tyr Met Leu Ala Ala Ser Leu Leu Gly Leu Gly Leu His Pro 
    210                 215                 220                 


Ile Ser Gly His Phe Ile Ala Glu His Tyr Met Phe Leu Lys Gly His 
225                 230                 235                 240 


Glu Thr Tyr Ser Tyr Tyr Gly Pro Leu Asn Leu Leu Thr Phe Asn Val 
                245                 250                 255     


Gly Tyr His Asn Glu His His Asp Phe Pro Asn Ile Pro Gly Lys Ser 
            260                 265                 270         


Leu Pro Leu Ser Trp Ser Phe Leu Asp Gly Cys Ser Gly Ser His Leu 
        275                 280                 285             


<210>  5906
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  5906

Met Gly Trp Thr Met Arg Leu Val Thr Ala Ala Leu Leu Leu Gly Leu 
1               5                   10                  15      


Met Met Val Val Thr Gly Asp Glu Asp Glu Asn Ser Pro Cys Ala His 
            20                  25                  30          


Glu Ala Leu Leu Asp Glu Asp Thr Leu Phe Cys Gln Gly Leu Glu Val 
        35                  40                  45              


Phe Tyr Pro Glu Leu Gly Asn Ile Gly Cys Lys Val Val Pro Asp Cys 
    50                  55                  60                  


Asn Asn Tyr Arg Gln Lys Ile Thr Ser Trp Met Glu Pro Ile Val Lys 
65                  70                  75                  80  


Phe Pro Gly Ala Val Asp Gly Ala Thr Tyr Ile Leu Val Met Val Asp 
                85                  90                  95      


Pro Asp Ala Pro Ser Arg Ala Glu Pro Arg Gln Arg Phe Trp Arg His 
            100                 105                 110         


Trp Leu Val Thr Asp Ile Lys Gly Ala Asp Leu Lys Lys Gly Lys Ile 
        115                 120                 125             


Gln Gly Gln Glu Leu Ser Ala Tyr Gln Ala Pro Ser Pro Pro Ala His 
    130                 135                 140                 


Ser Gly Phe His Arg Tyr Gln Phe Phe Val Tyr Leu Gln Glu Gly Lys 
145                 150                 155                 160 


Val Ile Ser Leu Leu Pro Lys Glu Asn Lys Thr Arg Gly Ser Trp Lys 
                165                 170                 175     


Met Asp Arg Phe Leu Asn Arg Phe His Leu Gly Glu Pro Glu Ala Ser 
            180                 185                 190         


Thr Gln Phe Met Thr Gln Asn Tyr Gln Asp Ser Pro Thr Leu Gln Ala 
        195                 200                 205             


Pro Arg Glu Arg Ala Ser Glu Pro Lys His Lys Asn Gln Ala Glu Ile 
    210                 215                 220                 


Ala Ala Cys 
225         


<210>  5907
<211>  2179
<212>  PRT
<213>  Homo sapiens

<400>  5907

Met Asn Ser Leu Ser Trp Gly Ala Ala Asn Ala Val Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ala Trp Ala Ser Pro Thr Phe Ile Ser Ile Asn Arg Gly Val 
            20                  25                  30          


Arg Val Met Lys Gly His Ser Ala Phe Leu Ser Gly Asp Asp Leu Lys 
        35                  40                  45              


Phe Ala Ile Pro Lys Glu Lys Asp Ala Cys Lys Val Glu Val Val Met 
    50                  55                  60                  


Asn Glu Pro Ile Thr Gln Arg Val Gly Lys Leu Thr Pro Gln Val Phe 
65                  70                  75                  80  


Asp Cys His Phe Leu Pro Asn Glu Val Lys Tyr Val His Asn Gly Cys 
                85                  90                  95      


Pro Ile Leu Asp Glu Asp Thr Val Lys Leu Arg Leu Tyr Arg Phe Thr 
            100                 105                 110         


Glu Arg Asp Thr Phe Ile Glu Thr Phe Ile Leu Trp Val Tyr Leu Leu 
        115                 120                 125             


Glu Pro Asp Cys Asn Ile Ile His Met Ser Asn Asn Val Leu Glu Val 
    130                 135                 140                 


Pro Glu Phe Asn Gly Leu Ser Gln Ala Ile Asp Lys Asn Leu Leu Arg 
145                 150                 155                 160 


Phe Asp Tyr Asp Arg Met Ala Ser Leu Glu Cys Thr Val Ser Leu Asp 
                165                 170                 175     


Thr Ala Arg Thr Arg Leu Pro Ala His Gly Gln Met Val Leu Gly Glu 
            180                 185                 190         


Pro Arg Pro Glu Glu Pro Arg Gly Asp Gln Pro His Ser Phe Phe Pro 
        195                 200                 205             


Glu Ser Gln Leu Arg Ala Lys Leu Lys Cys Pro Gly Gly Ser Cys Thr 
    210                 215                 220                 


Pro Gly Leu Lys Lys Ile Gly Ser Leu Lys Val Ser Cys Glu Glu Phe 
225                 230                 235                 240 


Leu Leu Met Gly Leu Arg Tyr Gln His Leu Asp Pro Pro Ser Pro Asn 
                245                 250                 255     


Ile Asp Tyr Ile Ser Ile Gln Leu Asp Leu Thr Asp Thr Arg Ser Lys 
            260                 265                 270         


Ile Val Tyr Lys Ser Glu Ser Ala Trp Leu Pro Val Tyr Ile Arg Ala 
        275                 280                 285             


Gly Ile Pro Asn Gln Ile Pro Lys Ala Ala Phe Met Ala Val Phe Ile 
    290                 295                 300                 


Leu Glu Val Asp Gln Phe Ile Leu Thr Ser Leu Thr Thr Ser Val Leu 
305                 310                 315                 320 


Asp Cys Glu Glu Asp Glu Thr Pro Lys Pro Leu Leu Val Phe Asn Ile 
                325                 330                 335     


Thr Lys Ala Pro Leu Gln Gly Tyr Val Thr His Leu Leu Asp His Thr 
            340                 345                 350         


Arg Pro Ile Ser Ser Phe Thr Trp Lys Asp Leu Ser Asp Met Gln Ile 
        355                 360                 365             


Ala Tyr Gln Pro Pro Asn Ser Ser His Ser Glu Arg Arg His Asp Glu 
    370                 375                 380                 


Val Glu Leu Glu Val Tyr Asp Phe Phe Phe Glu Arg Ser Ala Pro Met 
385                 390                 395                 400 


Thr Val His Ile Ser Ile Arg Thr Ala Asp Thr Asn Ala Pro Arg Val 
                405                 410                 415     


Ser Trp Asn Thr Gly Leu Ser Leu Leu Glu Gly Gln Ser Arg Ala Ile 
            420                 425                 430         


Thr Trp Glu Gln Phe Gln Val Val Asp Asn Asp Asp Ile Gly Ala Val 
        435                 440                 445             


Arg Leu Val Thr Val Gly Gly Leu Gln His Gly Trp Leu Thr Leu Arg 
    450                 455                 460                 


Gly Gly Lys Gly Phe Leu Phe Thr Val Ala Asp Leu Gln Ala Gly Val 
465                 470                 475                 480 


Val Arg Tyr His His Asp Asp Ser Asp Ser Thr Lys Asp Phe Val Val 
                485                 490                 495     


Phe Arg Ile Phe Asp Gly His His Ser Ile Arg His Lys Phe Pro Ile 
            500                 505                 510         


Asn Val Leu Pro Lys Asp Asp Ser Pro Pro Phe Leu Ile Thr Asn Val 
        515                 520                 525             


Val Ile Glu Leu Glu Glu Gly Gln Thr Ile Leu Ile Gln Gly Ser Met 
    530                 535                 540                 


Leu Arg Ala Ser Asp Val Asp Ala Ser Asp Asp Tyr Ile Phe Phe Asn 
545                 550                 555                 560 


Ile Thr Lys Pro Pro Gln Ala Gly Glu Ile Met Lys Lys Pro Gly Pro 
                565                 570                 575     


Gly Leu Ile Gly Tyr Pro Val His Gly Phe Leu Gln Arg Asp Leu Phe 
            580                 585                 590         


Asn Gly Ile Ile Tyr Tyr Arg His Phe Gly Gly Glu Ile Phe Glu Asp 
        595                 600                 605             


Ser Phe Gln Phe Val Leu Trp Asp Ser His Glu Pro Pro Asn Leu Ser 
    610                 615                 620                 


Val Pro Gln Val Ala Thr Ile His Ile Thr Pro Val Asp Asp Gln Leu 
625                 630                 635                 640 


Pro Lys Glu Ala Pro Gly Val Ser Arg His Leu Val Val Lys Glu Thr 
                645                 650                 655     


Glu Val Ala Tyr Ile Thr Lys Lys Gln Leu His Phe Ile Asp Ser Glu 
            660                 665                 670         


Ser Tyr Asp Arg Glu Leu Val Tyr Thr Ile Thr Thr Pro Pro Phe Phe 
        675                 680                 685             


Ser Phe Ser His Arg His Leu Asp Ala Gly Lys Leu Phe Met Val Asp 
    690                 695                 700                 


Ser Ile Pro Lys Val Val Lys Asn Pro Thr Ala Leu Glu Leu Arg Ser 
705                 710                 715                 720 


Phe Thr Gln His Ala Val Asn Tyr Met Lys Val Ala Tyr Met Pro Pro 
                725                 730                 735     


Met Gln Asp Ile Gly Pro His Cys Arg Asp Val Gln Phe Thr Phe Ser 
            740                 745                 750         


Val Ser Asn Gln His Gly Gly Thr Leu His Gly Ile Cys Phe Asn Ile 
        755                 760                 765             


Thr Ile Leu Pro Val Asp Asn Gln Val Pro Glu Ala Phe Thr Asn Pro 
    770                 775                 780                 


Leu Lys Val Thr Glu Gly Gly Gln Ser Ile Ile Ser Thr Glu His Ile 
785                 790                 795                 800 


Leu Ile Ser Asp Ala Asp Thr Lys Leu Asp Asn Ile Asp Leu Ser Leu 
                805                 810                 815     


Arg Glu Leu Pro Leu His Gly Arg Val Glu Leu Asn Gly Phe Pro Leu 
            820                 825                 830         


Asn Ser Gly Gly Thr Phe Ser Trp Gly Asp Leu His Thr Leu Lys Val 
        835                 840                 845             


Arg Tyr Gln His Asp Gly Thr Glu Val Leu Gln Asp Asp Leu Leu Leu 
    850                 855                 860                 


Glu Val Thr Asp Gly Thr Asn Ser Ala Glu Phe Val Leu His Val Glu 
865                 870                 875                 880 


Val Phe Pro Val Asn Asp Glu Pro Pro Val Leu Lys Ala Asp Leu Met 
                885                 890                 895     


Pro Val Met Asn Cys Ser Glu Gly Gly Glu Val Val Ile Thr Ser Glu 
            900                 905                 910         


Tyr Ile Phe Ala Thr Asp Val Asp Ser Asp Asn Leu Lys Leu Met Phe 
        915                 920                 925             


Val Ile Ala Arg Glu Pro Gln His Gly Val Val Arg Arg Ala Gly Val 
    930                 935                 940                 


Thr Val Asp Gln Phe Ser Gln Arg Asp Val Ile Ser Glu Ala Val Thr 
945                 950                 955                 960 


Tyr Lys His Thr Gly Gly Glu Ile Gly Leu Met Pro Cys Phe Asp Thr 
                965                 970                 975     


Ile Thr Leu Val Val Ser Asp Gly Glu Ala Gly Pro Phe Val Asn Gly 
            980                 985                 990         


Cys Cys Tyr Asn Gly Pro Asn Pro  Ser Val Pro Leu His  Ala Ser Phe 
        995                 1000                 1005             


Pro Val  Tyr Asp Leu Asn Ile  Thr Val Tyr Pro Val  Asp Asn Gln 
    1010                 1015                 1020             


Pro Pro  Ser Ile Ala Ile Gly  Pro Val Phe Val Val  Asp Glu Gly 
    1025                 1030                 1035             


Cys Ser  Thr Ala Leu Thr Val  Asn His Leu Ser Ala  Thr Asp Pro 
    1040                 1045                 1050             


Asp Thr  Ala Ala Asp Asp Leu  Glu Phe Val Leu Val  Ser Pro Pro 
    1055                 1060                 1065             


Gln Phe  Gly Tyr Leu Glu Asn  Ile Leu Pro Ser Val  Gly Phe Glu 
    1070                 1075                 1080             


Lys Ser  Asn Ile Gly Ile Ser  Ile Asp Ser Phe Gln  Trp Lys Asp 
    1085                 1090                 1095             


Met Asn  Ala Phe His Ile Asn  Tyr Val Gln Ser Arg  His Leu Arg 
    1100                 1105                 1110             


Ile Glu  Pro Thr Ala Asp Gln  Phe Thr Val Tyr Val  Thr Asp Gly 
    1115                 1120                 1125             


Lys His  His Ser Leu Glu Ile  Pro Phe Ser Ile Ile  Ile Asn Pro 
    1130                 1135                 1140             


Thr Asn  Asp Glu Ala Pro Asp  Phe Val Val Gln Asn  Ile Thr Val 
    1145                 1150                 1155             


Cys Glu  Gly Gln Met Lys Glu  Leu Asp Ser Ser Ile  Ile Ser Ala 
    1160                 1165                 1170             


Val Asp  Leu Asp Ile Pro Gln  Asp Ala Leu Leu Phe  Ser Ile Thr 
    1175                 1180                 1185             


Gln Lys  Pro Arg His Gly Leu  Leu Ile Asp Arg Gly  Phe Ser Lys 
    1190                 1195                 1200             


Asp Phe  Ser Glu Asn Lys Gln  Pro Ala Asn Pro His  Gln Lys His 
    1205                 1210                 1215             


Ala Pro  Val His Ser Phe Ser  Met Glu Leu Leu Lys  Thr Gly Met 
    1220                 1225                 1230             


Arg Leu  Thr Tyr Met His Asp  Asp Ser Glu Ser Leu  Ala Asp Asp 
    1235                 1240                 1245             


Phe Thr  Ile Gln Leu Ser Asp  Gly Lys His Lys Ile  Leu Lys Thr 
    1250                 1255                 1260             


Ile Ser  Val Glu Val Ile Pro  Val Asn Asp Glu Lys  Pro Met Leu 
    1265                 1270                 1275             


Ser Lys  Lys Ala Glu Ile Ala  Met Asn Met Gly Glu  Thr Arg Ile 
    1280                 1285                 1290             


Ile Ser  Ser Ala Ile Leu Ser  Ala Ile Asp Glu Asp  Ser Pro Arg 
    1295                 1300                 1305             


Glu Lys  Ile Tyr Tyr Val Phe  Glu Arg Leu Pro Gln  Asn Gly Gln 
    1310                 1315                 1320             


Leu Gln  Leu Lys Ile Gly Arg  Asp Trp Val Pro Leu  Ser Pro Gly 
    1325                 1330                 1335             


Met Lys  Cys Thr Gln Glu Glu  Val Asp Leu Asn Leu  Leu Arg Tyr 
    1340                 1345                 1350             


Thr His  Thr Gly Ala Met Asp  Ser Gln Asn Gln Asp  Ser Phe Thr 
    1355                 1360                 1365             


Phe Tyr  Leu Trp Asp Gly Asn  Asn Arg Ser Pro Ala  Leu Asp Cys 
    1370                 1375                 1380             


Gln Ile  Thr Ile Lys Asp Met  Glu Lys Gly Asp Ile  Val Ile Leu 
    1385                 1390                 1395             


Thr Lys  Pro Leu Val Val Ser  Lys Gly Asp Arg Gly  Phe Leu Thr 
    1400                 1405                 1410             


Thr Thr  Thr Leu Leu Ala Val  Asp Gly Thr Asp Lys  Pro Glu Glu 
    1415                 1420                 1425             


Leu Leu  Tyr Val Ile Thr Ser  Pro Pro Arg Tyr Gly  Gln Ile Glu 
    1430                 1435                 1440             


Tyr Val  His Tyr Pro Gly Val  Pro Ile Thr Asn Phe  Ser Gln Met 
    1445                 1450                 1455             


Asp Val  Val Gly Gln Thr Val  Cys Tyr Val His Lys  Ser Lys Val 
    1460                 1465                 1470             


Thr Val  Ser Ser Asp Arg Phe  Arg Phe Ile Ile Ser  Asn Gly Leu 
    1475                 1480                 1485             


Arg Thr  Glu His Gly Val Phe  Glu Ile Thr Leu Glu  Thr Val Asp 
    1490                 1495                 1500             


Arg Ala  Leu Pro Val Val Thr  Arg Asn Lys Gly Leu  Arg Leu Ala 
    1505                 1510                 1515             


Gln Gly  Ala Val Gly Leu Leu  Ser Pro Asp Leu Leu  Gln Leu Thr 
    1520                 1525                 1530             


Asp Pro  Asp Thr Pro Ala Glu  Asn Leu Thr Phe Leu  Leu Val Gln 
    1535                 1540                 1545             


Leu Pro  Gln His Gly Gln Leu  Tyr Leu Trp Gly Thr  Gly Leu Leu 
    1550                 1555                 1560             


Gln His  Asn Phe Thr Gln Gln  Asp Val Asp Ser Lys  Asn Val Ala 
    1565                 1570                 1575             


Tyr Arg  His Ser Gly Gly Asp  Ser Gln Thr Asp Cys  Phe Thr Phe 
    1580                 1585                 1590             


Met Ala  Thr Asp Gly Thr Asn  Gln Gly Phe Ile Val  Asn Gly Arg 
    1595                 1600                 1605             


Val Trp  Glu Glu Pro Val Leu  Phe Thr Ile Gln Val  Asp Gln Leu 
    1610                 1615                 1620             


Asp Lys  Thr Ala Pro Arg Ile  Thr Leu Leu His Ser  Pro Ser Gln 
    1625                 1630                 1635             


Val Gly  Leu Leu Lys Asn Gly  Cys Tyr Gly Ile Tyr  Ile Thr Ser 
    1640                 1645                 1650             


Arg Val  Leu Lys Ala Ser Asp  Pro Asp Thr Glu Asp  Asp Gln Ile 
    1655                 1660                 1665             


Ile Phe  Lys Ile Leu Gln Gly  Pro Lys His Gly His  Leu Glu Asn 
    1670                 1675                 1680             


Thr Thr  Thr Gly Glu Phe Ile  His Glu Lys Phe Ser  Gln Lys Asp 
    1685                 1690                 1695             


Leu Asn  Ser Lys Thr Ile Leu  Tyr Ile Ile Asn Pro  Ser Leu Glu 
    1700                 1705                 1710             


Val Asn  Ser Asp Thr Val Glu  Phe Gln Ile Met Asp  Pro Thr Gly 
    1715                 1720                 1725             


Asn Ser  Ala Thr Pro Gln Ile  Leu Glu Leu Lys Trp  Ser His Ile 
    1730                 1735                 1740             


Glu Trp  Ser Gln Thr Glu Tyr  Glu Val Cys Glu Asn  Val Gly Leu 
    1745                 1750                 1755             


Leu Pro  Leu Glu Ile Ile Arg  Arg Gly Tyr Ser Met  Asp Ser Ala 
    1760                 1765                 1770             


Phe Val  Gly Ile Lys Val Asn  Gln Val Ser Ala Ala  Val Gly Lys 
    1775                 1780                 1785             


Asp Phe  Thr Val Ile Pro Ser  Lys Leu Ile Gln Phe  Asp Pro Gly 
    1790                 1795                 1800             


Met Ser  Thr Lys Met Trp Asn  Ile Ala Ile Thr Tyr  Asp Gly Leu 
    1805                 1810                 1815             


Glu Glu  Asp Asp Glu Val Phe  Glu Val Ile Leu Asn  Ser Pro Val 
    1820                 1825                 1830             


Asn Ala  Val Leu Gly Thr Lys  Thr Lys Ala Ala Val  Lys Ile Leu 
    1835                 1840                 1845             


Asp Ser  Lys Gly Gly Gln Cys  His Pro Ser Tyr Ser  Ser Asn Gln 
    1850                 1855                 1860             


Ser Lys  His Ser Thr Trp Glu  Lys Gly Ile Trp His  Leu Leu Pro 
    1865                 1870                 1875             


Pro Gly  Ser Ser Ser Ser Thr  Thr Ser Gly Ser Phe  His Leu Glu 
    1880                 1885                 1890             


Arg Arg  Pro Leu Pro Ser Ser  Met Gln Leu Ala Val  Ile Arg Gly 
    1895                 1900                 1905             


Asp Thr  Leu Arg Gly Phe Asp  Ser Thr Asp Leu Ser  Gln Arg Lys 
    1910                 1915                 1920             


Leu Arg  Thr Arg Gly Asn Gly  Lys Thr Val Arg Pro  Ser Ser Val 
    1925                 1930                 1935             


Tyr Arg  Asn Gly Thr Asp Ile  Ile Tyr Asn Tyr His  Gly Ile Val 
    1940                 1945                 1950             


Ser Leu  Lys Leu Glu Asp Asp  Ser Phe Pro Thr His  Lys Arg Lys 
    1955                 1960                 1965             


Ala Lys  Val Ser Ile Ile Ser  Gln Pro Gln Lys Thr  Ile Lys Val 
    1970                 1975                 1980             


Ala Glu  Leu Pro Gln Ala Asp  Lys Val Glu Ser Thr  Thr Asp Ser 
    1985                 1990                 1995             


His Phe  Pro Arg Gln Asp Gln  Leu Pro Ser Phe Pro  Lys Asn Cys 
    2000                 2005                 2010             


Thr Leu  Glu Leu Lys Gly Leu  Phe His Phe Glu Glu  Gly Ile Gln 
    2015                 2020                 2025             


Lys Leu  Tyr Gln Cys Asn Gly  Ile Ala Trp Lys Ala  Trp Ser Pro 
    2030                 2035                 2040             


Gln Thr  Lys Asp Val Glu Asp  Lys Ser Cys Pro Ala  Gly Trp His 
    2045                 2050                 2055             


Gln His  Ser Gly Tyr Cys His  Ile Leu Ile Thr Glu  Gln Lys Gly 
    2060                 2065                 2070             


Thr Trp  Asn Ala Ala Ala Gln  Ala Cys Arg Glu Gln  Tyr Leu Gly 
    2075                 2080                 2085             


Asn Leu  Val Thr Val Phe Ser  Arg Gln His Met Arg  Trp Leu Trp 
    2090                 2095                 2100             


Asp Ile  Gly Gly Arg Lys Ser  Phe Trp Ile Gly Leu  Asn Asp Gln 
    2105                 2110                 2115             


Val His  Ala Gly His Trp Glu  Trp Ile Gly Gly Glu  Pro Val Ala 
    2120                 2125                 2130             


Phe Thr  Asn Gly Arg Arg Gly  Pro Ser Gln Arg Ser  Lys Leu Gly 
    2135                 2140                 2145             


Lys Ser  Cys Val Leu Val Gln  Arg Gln Gly Lys Trp  Gln Thr Lys 
    2150                 2155                 2160             


Asp Cys  Arg Arg Ala Lys Pro  His Asn Tyr Val Cys  Ser Arg Lys 
    2165                 2170                 2175             


Leu 
    


<210>  5908
<211>  547
<212>  PRT
<213>  Homo sapiens

<400>  5908

Met Gly Gly Cys Ile Pro Phe Leu Lys Ala Ala Arg Ala Leu Cys Pro 
1               5                   10                  15      


Arg Ile Met Pro Pro Leu Leu Leu Leu Ser Ala Phe Ile Phe Leu Val 
            20                  25                  30          


Ser Val Leu Gly Gly Ala Pro Gly His Asn Pro Asp Arg Arg Thr Lys 
        35                  40                  45              


Met Val Ser Ile His Ser Leu Ser Glu Leu Glu Arg Leu Lys Leu Gln 
    50                  55                  60                  


Glu Thr Ala Tyr His Glu Leu Val Ala Arg His Phe Leu Ser Glu Phe 
65                  70                  75                  80  


Lys Pro Asp Arg Ala Leu Pro Ile Asp Arg Pro Asn Thr Leu Asp Lys 
                85                  90                  95      


Trp Phe Leu Ile Leu Arg Gly Gln Gln Arg Ala Val Ser His Lys Thr 
            100                 105                 110         


Phe Gly Ile Ser Leu Glu Glu Val Leu Val Asn Glu Phe Thr Arg Arg 
        115                 120                 125             


Lys His Leu Glu Leu Thr Ala Thr Met Gln Val Glu Glu Ala Thr Gly 
    130                 135                 140                 


Gln Ala Ala Gly Arg Arg Arg Gly Asn Val Val Arg Arg Val Phe Gly 
145                 150                 155                 160 


Arg Ile Arg Arg Phe Phe Ser Arg Arg Arg Asn Glu Pro Thr Leu Pro 
                165                 170                 175     


Arg Glu Phe Thr Arg Arg Gly Arg Arg Gly Ala Val Ser Val Asp Ser 
            180                 185                 190         


Leu Ala Glu Leu Glu Asp Gly Ala Leu Leu Leu Gln Thr Leu Gln Leu 
        195                 200                 205             


Ser Lys Ile Ser Phe Pro Ile Gly Gln Arg Leu Leu Gly Ser Lys Arg 
    210                 215                 220                 


Lys Met Ser Leu Asn Pro Ile Ala Lys Gln Ile Pro Gln Val Val Glu 
225                 230                 235                 240 


Ala Cys Cys Gln Phe Ile Glu Lys His Gly Leu Ser Ala Val Gly Ile 
                245                 250                 255     


Phe Thr Leu Glu Tyr Ser Val Gln Arg Val Arg Gln Leu Arg Glu Glu 
            260                 265                 270         


Phe Asp Gln Gly Leu Asp Val Val Leu Asp Asp Asn Gln Asn Val His 
        275                 280                 285             


Asp Val Ala Ala Leu Leu Lys Glu Phe Phe Arg Asp Met Lys Asp Ser 
    290                 295                 300                 


Leu Leu Pro Asp Asp Leu Tyr Met Ser Phe Leu Leu Thr Ala Thr Leu 
305                 310                 315                 320 


Lys Pro Gln Asp Gln Leu Ser Ala Leu Gln Leu Leu Val Tyr Leu Met 
                325                 330                 335     


Pro Pro Cys His Ser Asp Thr Leu Glu Arg Leu Leu Lys Ala Leu His 
            340                 345                 350         


Lys Ile Thr Glu Asn Cys Glu Asp Ser Ile Gly Ile Asp Gly Gln Leu 
        355                 360                 365             


Val Pro Gly Asn Arg Met Thr Ser Thr Asn Leu Ala Leu Val Phe Gly 
    370                 375                 380                 


Ser Ala Leu Leu Lys Lys Gly Lys Phe Gly Lys Arg Glu Ser Arg Lys 
385                 390                 395                 400 


Thr Lys Leu Gly Ile Asp His Tyr Val Ala Ser Val Asn Val Val Arg 
                405                 410                 415     


Ala Met Ile Asp Asn Trp Asp Val Leu Phe Gln Val Pro Pro His Ile 
            420                 425                 430         


Gln Arg Gln Val Ala Lys Arg Val Trp Lys Ser Ser Pro Glu Ala Leu 
        435                 440                 445             


Asp Phe Ile Arg Arg Arg Asn Leu Arg Lys Ile Gln Ser Ala Arg Ile 
    450                 455                 460                 


Lys Met Glu Glu Asp Ala Leu Leu Ser Asp Pro Val Glu Thr Ser Ala 
465                 470                 475                 480 


Glu Ala Arg Ala Ala Val Leu Ala Gln Ser Lys Pro Ser Asp Glu Gly 
                485                 490                 495     


Ser Ser Glu Glu Pro Ala Val Pro Ser Gly Thr Ala Arg Ser His Asp 
            500                 505                 510         


Asp Glu Glu Gly Ala Gly Asn Pro Pro Ile Pro Glu Gln Asp Arg Pro 
        515                 520                 525             


Leu Leu Arg Val Pro Arg Glu Lys Glu Ala Lys Thr Gly Val Ser Tyr 
    530                 535                 540                 


Phe Phe Pro 
545         


<210>  5909
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  5909

Met Arg Arg Gly Trp Lys Met Ala Leu Ser Gly Gly Leu Arg Cys Cys 
1               5                   10                  15      


Arg Arg Val Leu Ser Trp Val Pro Val Leu Val Ile Val Leu Val Val 
            20                  25                  30          


Leu Trp Ser Tyr Tyr Ala Tyr Val Phe Glu Leu Cys Leu Val Thr Val 
        35                  40                  45              


Leu Ser Pro Ala Glu Lys Val Ile Tyr Leu Ile Leu Tyr His Ala Ile 
    50                  55                  60                  


Phe Val Phe Phe Thr Trp Thr Tyr Trp Lys Ser Ile Phe Thr Leu Pro 
65                  70                  75                  80  


Gln Gln Pro Asn Gln Lys Phe His Leu Ser Tyr Thr Asp Lys Glu Arg 
                85                  90                  95      


Tyr Glu Asn Glu Glu Arg Pro Glu Val Gln Lys Gln Met Leu Val Asp 
            100                 105                 110         


Met Ala Lys Lys Leu Pro Val Tyr Thr Arg Thr Gly Ser Gly Ala Val 
        115                 120                 125             


Arg Phe Cys Asp Arg Cys His Leu Ile Lys Pro Asp Arg Cys His His 
    130                 135                 140                 


Cys Ser Val Cys Ala Met Cys Val Leu Lys Met Asp His His Cys Pro 
145                 150                 155                 160 


Trp Val Asn Asn Cys Ile Gly Phe Ser Asn Tyr Lys Phe Phe Leu Gln 
                165                 170                 175     


Phe Leu Ala Tyr Ser Val Leu Tyr Cys Leu Tyr Ile Ala Thr Thr Val 
            180                 185                 190         


Phe Ser Tyr Phe Ile Lys Tyr Trp Arg Gly Glu Leu Pro Ser Val Arg 
        195                 200                 205             


Ser Lys Phe His Val Leu Phe Leu Leu Phe Val Ala Cys Met Phe Phe 
    210                 215                 220                 


Val Ser Leu Val Ile Leu Phe Gly Tyr His Cys Trp Leu Val Ser Arg 
225                 230                 235                 240 


Asn Lys Thr Thr Leu Glu Ala Phe Cys Thr Pro Val Phe Thr Ser Gly 
                245                 250                 255     


Pro Glu Lys Asn Gly Phe Asn Leu Gly Phe Ile Lys Asn Ile Gln Gln 
            260                 265                 270         


Val Phe Gly Asp Lys Lys Lys Phe Trp Leu Ile Pro Ile Gly Ser Ser 
        275                 280                 285             


Pro Gly Asp Gly His Ser Phe Pro Met Arg Ser Met Asn Glu Ser Gln 
    290                 295                 300                 


Asn Pro Leu Leu Ala Asn Glu Glu Thr Trp Glu Asp Asn Glu Asp Asp 
305                 310                 315                 320 


Asn Gln Asp Tyr Pro Glu Gly Ser Ser Ser Leu Ala Val Glu Thr Glu 
                325                 330                 335     


Thr 
    


<210>  5910
<211>  1274
<212>  PRT
<213>  Homo sapiens

<400>  5910

Met Ser Gly Ser Cys Ala Ala Pro Gly Pro Gly Ser Gly Ser Ser Pro 
1               5                   10                  15      


Ala Ala Cys Arg Phe Ala His Tyr Phe Val Leu Cys Gly Ile Asp Ala 
            20                  25                  30          


Asp Ser Gly Leu Glu Pro Asp Glu Leu Ala Gly Glu Asn Phe Asp Gln 
        35                  40                  45              


Ser Pro Leu Arg Arg Thr Phe Lys Ser Lys Val Leu Ala His Tyr Pro 
    50                  55                  60                  


Gln Asn Ile Glu Trp Asn Pro Phe Asp Gln Asp Ala Val Asn Met Leu 
65                  70                  75                  80  


Cys Met Pro Lys Gly Leu Ser Phe Arg Thr Gln Thr Asp Asn Lys Asp 
                85                  90                  95      


Pro Gln Phe His Ser Phe Ile Ile Thr Arg Glu Asp Gly Ser Arg Thr 
            100                 105                 110         


Tyr Gly Phe Val Leu Thr Phe Tyr Glu Glu Val Thr Ser Lys Gln Ile 
        115                 120                 125             


Cys Thr Ala Met Gln Thr Leu Tyr Gln Met His Asn Ala Glu His Tyr 
    130                 135                 140                 


Ser Ser Val Tyr Ala Ser Ser Ser Cys Ser Met Asp Ser Leu Ala Ser 
145                 150                 155                 160 


Ser Leu Asp Glu Gly Asp Thr Thr Ser Leu Leu Lys Leu Gln Arg Tyr 
                165                 170                 175     


Asn Ser Tyr Asp Ile Ser Arg Asp Thr Leu Tyr Val Ser Lys Ser Ile 
            180                 185                 190         


Cys Leu Ile Thr Pro Leu Pro Phe Met Gln Ala Cys Lys Lys Phe Leu 
        195                 200                 205             


Ile Gln Leu Tyr Lys Ala Val Thr Ser Gln Gln Pro Pro Pro Leu Pro 
    210                 215                 220                 


Leu Glu Ser Tyr Ile His Asn Ile Leu Tyr Glu Val Pro Leu Pro Pro 
225                 230                 235                 240 


Pro Gly Arg Ser Leu Lys Phe Tyr Gly Val Tyr Glu Pro Val Ile Cys 
                245                 250                 255     


Gln Arg Pro Gly Pro Ser Glu Leu Pro Leu Ser Asp Tyr Pro Leu Arg 
            260                 265                 270         


Glu Ala Phe Glu Leu Leu Gly Leu Glu Asn Leu Val Gln Val Phe Thr 
        275                 280                 285             


Cys Val Leu Leu Glu Met Gln Ile Leu Leu Tyr Ser Gln Asp Tyr Gln 
    290                 295                 300                 


Arg Leu Met Thr Val Ala Glu Gly Ile Thr Thr Leu Leu Phe Pro Phe 
305                 310                 315                 320 


Gln Trp Gln His Val Tyr Val Pro Ile Leu Pro Ala Ser Leu Leu His 
                325                 330                 335     


Phe Leu Asp Ala Pro Val Pro Tyr Leu Met Gly Leu Gln Ser Lys Glu 
            340                 345                 350         


Gly Thr Asp Arg Ser Lys Leu Glu Leu Pro Gln Glu Ala Asn Leu Cys 
        355                 360                 365             


Phe Val Asp Ile Asp Asn His Phe Ile Glu Leu Pro Glu Glu Phe Pro 
    370                 375                 380                 


Gln Phe Pro Asn Lys Val Asp Phe Ile Gln Glu Leu Ser Glu Val Leu 
385                 390                 395                 400 


Val Gln Phe Gly Ile Pro Pro Glu Gly Ser Leu His Cys Ser Glu Ser 
                405                 410                 415     


Thr Ser Lys Leu Lys Asn Met Val Leu Lys Asp Leu Val Asn Asp Lys 
            420                 425                 430         


Lys Asn Gly Asn Val Cys Thr Asn Asn Ile Ser Met Tyr Glu Leu Leu 
        435                 440                 445             


Lys Gly Asn Glu Thr Ile Ala Arg Leu Gln Ala Leu Ala Lys Arg Thr 
    450                 455                 460                 


Gly Val Ala Val Glu Lys Met Asp Leu Ser Ala Ser Leu Gly Glu Lys 
465                 470                 475                 480 


Asp Lys Asp Leu Lys Leu His Cys Glu Glu Ala Glu Leu Arg Asp Tyr 
                485                 490                 495     


Gln Leu Asn Val Gln Leu Arg Glu Val Phe Ala Asn Arg Phe Thr Gln 
            500                 505                 510         


Met Phe Ala Asp Tyr Glu Ala Phe Val Ile Gln Thr Ala Gln Asp Met 
        515                 520                 525             


Glu Ser Trp Leu Thr Asn Arg Glu Gln Met Gln Asn Phe Asp Lys Ala 
    530                 535                 540                 


Ser Phe Leu Ser Asp Gln Pro Glu Pro Tyr Leu Pro Phe Leu Ser Arg 
545                 550                 555                 560 


Phe Ile Glu Thr Gln Met Phe Ala Thr Phe Ile Asp Asn Lys Ile Met 
                565                 570                 575     


Ser Gln Trp Glu Glu Lys Asp Pro Leu Leu Arg Val Phe Asp Thr Arg 
            580                 585                 590         


Ile Asp Lys Ile Arg Leu Tyr Asn Val Arg Ala Pro Thr Leu Arg Thr 
        595                 600                 605             


Ser Ile Tyr Gln Lys Cys Ser Thr Leu Lys Glu Ala Ala Gln Ser Ile 
    610                 615                 620                 


Glu Gln Arg Leu Met Lys Met Asp His Thr Ala Ile His Pro His Leu 
625                 630                 635                 640 


Leu Asp Met Lys Ile Gly Gln Gly Lys Tyr Glu Gln Gly Phe Phe Pro 
                645                 650                 655     


Lys Leu Gln Ser Asp Val Leu Ala Thr Gly Pro Thr Ser Asn Asn Arg 
            660                 665                 670         


Trp Val Ser Arg Ser Ala Thr Ala Gln Arg Arg Lys Glu Arg Leu Arg 
        675                 680                 685             


Gln His Ser Glu His Val Gly Leu Asp Asn Asp Leu Arg Glu Lys Tyr 
    690                 695                 700                 


Met Gln Glu Ala Arg Ser Leu Gly Lys Asn Leu Arg Gln Pro Lys Leu 
705                 710                 715                 720 


Ser Asp Leu Ser Pro Ala Val Ile Ala Gln Thr Asn Cys Lys Phe Val 
                725                 730                 735     


Glu Gly Leu Leu Lys Glu Cys Arg Met Lys Thr Lys Arg Met Leu Val 
            740                 745                 750         


Glu Lys Met Gly His Glu Ala Val Glu Leu Gly His Gly Glu Ala Asn 
        755                 760                 765             


Ile Thr Gly Leu Glu Glu Asn Thr Leu Ile Ala Ser Leu Cys Asp Leu 
    770                 775                 780                 


Leu Glu Arg Ile Trp Ser His Gly Leu Gln Val Lys Gln Gly Lys Ser 
785                 790                 795                 800 


Ala Leu Trp Ser His Leu Ile Gln Phe Gln Asp Arg Glu Glu Lys Gln 
                805                 810                 815     


Glu His Leu Ala Glu Ser Pro Val Ala Leu Gly Pro Glu Arg Arg Lys 
            820                 825                 830         


Ser Asp Ser Gly Val Met Leu Pro Thr Leu Arg Val Ser Leu Ile Gln 
        835                 840                 845             


Asp Met Arg His Ile Gln Asn Met Ser Glu Ile Lys Thr Asp Val Gly 
    850                 855                 860                 


Arg Ala Arg Ala Trp Ile Arg Leu Ser Leu Glu Lys Lys Leu Leu Ser 
865                 870                 875                 880 


Gln His Leu Lys Gln Leu Leu Ser Asn Gln Pro Leu Thr Lys Lys Leu 
                885                 890                 895     


Tyr Lys Arg Tyr Ala Phe Leu Arg Cys Glu Glu Glu Arg Glu Gln Phe 
            900                 905                 910         


Leu Tyr His Leu Leu Ser Leu Asn Ala Val Asp Tyr Phe Cys Phe Thr 
        915                 920                 925             


Ser Val Phe Thr Thr Ile Met Ile Pro Tyr Arg Ser Val Ile Ile Pro 
    930                 935                 940                 


Ile Lys Lys Leu Ser Asn Ala Ile Ile Thr Ser Asn Pro Trp Ile Cys 
945                 950                 955                 960 


Val Ser Gly Glu Leu Gly Asp Thr Gly Val Met Gln Ile Pro Lys Asn 
                965                 970                 975     


Leu Leu Glu Met Thr Phe Glu Cys Gln Asn Leu Gly Lys Leu Thr Thr 
            980                 985                 990         


Val Gln Ile Gly His Asp Asn Ser  Gly Leu Leu Ala Lys  Trp Leu Val 
        995                 1000                 1005             


Asp Cys  Val Met Val Arg Asn  Glu Ile Thr Gly His  Thr Tyr Arg 
    1010                 1015                 1020             


Phe Pro  Cys Gly Arg Trp Leu  Gly Lys Gly Ile Asp  Asp Gly Ser 
    1025                 1030                 1035             


Leu Glu  Arg Ile Leu Ile Gly  Glu Leu Met Thr Ser  Ala Ser Asp 
    1040                 1045                 1050             


Glu Asp  Leu Val Lys Gln Cys  Arg Thr Pro Pro Gln  Gln Lys Ser 
    1055                 1060                 1065             


Pro Thr  Thr Ala Arg Arg Leu  Ser Ile Thr Ser Leu  Thr Gly Lys 
    1070                 1075                 1080             


Asn Asn  Lys Pro Asn Ala Gly  Gln Ile Gln Glu Gly  Ile Gly Glu 
    1085                 1090                 1095             


Ala Val  Asn Asn Ile Val Lys  His Phe His Lys Pro  Glu Lys Glu 
    1100                 1105                 1110             


Arg Gly  Ser Leu Thr Val Leu  Leu Cys Gly Glu Asn  Gly Leu Val 
    1115                 1120                 1125             


Ala Ala  Leu Glu Gln Val Phe  His His Gly Phe Lys  Ser Ala Arg 
    1130                 1135                 1140             


Ile Phe  His Lys Asn Val Phe  Ile Trp Asp Phe Ile  Glu Lys Val 
    1145                 1150                 1155             


Val Ala  Tyr Phe Glu Thr Thr  Asp Gln Ile Leu Asp  Asn Glu Asp 
    1160                 1165                 1170             


Asp Val  Leu Ile Gln Lys Ser  Ser Cys Lys Thr Phe  Cys His Tyr 
    1175                 1180                 1185             


Val Asn  Ala Ile Asn Thr Ala  Pro Arg Asn Ile Gly  Lys Asp Gly 
    1190                 1195                 1200             


Lys Phe  Gln Ile Leu Val Cys  Leu Gly Thr Arg Asp  Arg Leu Leu 
    1205                 1210                 1215             


Pro Gln  Trp Ile Pro Leu Leu  Ala Glu Cys Pro Ala  Ile Thr Arg 
    1220                 1225                 1230             


Met Tyr  Glu Glu Ser Ala Leu  Leu Arg Asp Arg Met  Thr Val Asn 
    1235                 1240                 1245             


Ser Leu  Ile Arg Ile Leu Gln  Thr Ile Gln Asp Phe  Thr Ile Val 
    1250                 1255                 1260             


Leu Glu  Gly Ser Leu Ile Lys  Gly Val Asp Val 
    1265                 1270                 


<210>  5911
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  5911

Met Asp Cys Arg Thr Lys Ala Asn Pro Asp Arg Thr Phe Asp Leu Val 
1               5                   10                  15      


Leu Lys Val Lys Cys His Ala Ser Glu Asn Glu Asp Pro Val Val Leu 
            20                  25                  30          


Trp Lys Phe Pro Glu Asp Phe Gly Asp Gln Glu Ile Leu Gln Ser Val 
        35                  40                  45              


Pro Lys Phe Cys Phe Pro Phe Asp Val Glu Arg Val Ser Gln Asn Gln 
    50                  55                  60                  


Val Gly Gln His Phe Thr Phe Val Leu Thr Asp Ile Glu Ser Lys Gln 
65                  70                  75                  80  


Arg Phe Gly Phe Cys Arg Leu Thr Ser Gly Gly Thr Ile Cys Leu Cys 
                85                  90                  95      


Ile Leu Ser Tyr Leu Pro Trp Phe Glu Val Tyr Tyr Lys Leu Leu Asn 
            100                 105                 110         


Thr Leu Ala Asp Tyr Leu Ala Lys Glu Leu Glu Asn Asp Leu Asn Glu 
        115                 120                 125             


Thr Leu Arg Ser Leu Tyr Asn His Pro Val Pro Lys Ala Asn Thr Pro 
    130                 135                 140                 


Val Asn Leu Ser Val Asn Gln Glu Ile Phe Ile Ala Cys Glu Gln Val 
145                 150                 155                 160 


Leu Lys Asp Gln Pro Ala Leu Val Pro His Ser Tyr Phe Ile Ala Pro 
                165                 170                 175     


Asp Val Thr Gly Leu Pro Thr Ile Pro Glu Ser Arg Asn Leu Thr Glu 
            180                 185                 190         


Tyr Phe Val Ala Val Asp Val Asn Asn Met Leu Gln Leu Tyr Ala Ser 
        195                 200                 205             


Met Leu His Glu Arg Arg Ile Val Ile Ile Ser Ser Lys Leu Ser Thr 
    210                 215                 220                 


Leu Thr Ala Cys Ile His Gly Ser Ala Ala Leu Leu Tyr Pro Met Tyr 
225                 230                 235                 240 


Trp Gln His Ile Tyr Ile Pro Val Leu Pro Pro His Leu Leu Asp Tyr 
                245                 250                 255     


Cys Cys Ala Pro Met Pro Tyr Leu Ile Gly Ile His Ser Ser Leu Ile 
            260                 265                 270         


Glu Arg Val Lys Asn Lys Ser Leu Glu Asp Val Val Met Leu Asn Val 
        275                 280                 285             


Asp Thr Asn Thr Leu Glu Ser Pro Phe Ser Asp Leu Asn Asn Leu Pro 
    290                 295                 300                 


Ser Asp Val Val Ser Ala Leu Lys Asn Lys Leu Lys Lys Gln Ser Thr 
305                 310                 315                 320 


Ala Thr Gly Asp Gly Val Ala Arg Ala Phe Leu Arg Ala Gln Ala Ala 
                325                 330                 335     


Leu Phe Gly Ser Tyr Arg Asp Ala Leu Arg Tyr Lys Pro Gly Glu Pro 
            340                 345                 350         


Ile Thr Phe Cys Glu Glu Ser Phe Val Lys His Arg Ser Ser Val Met 
        355                 360                 365             


Lys Gln Phe Leu Glu Thr Ala Ile Asn Leu Gln Leu Phe Lys Gln Phe 
    370                 375                 380                 


Ile Asp Gly Arg Leu Ala Lys Leu Asn Ala Gly Arg Gly Phe Ser Asp 
385                 390                 395                 400 


Val Phe Glu Glu Glu Ile Thr Ser Gly Gly Phe Cys Gly Gly Lys Asp 
                405                 410                 415     


Lys Leu Gln Tyr Asp Tyr Pro Phe Ser Gln 
            420                 425     


<210>  5912
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  5912

Met Arg Leu Leu Ala Leu Ala Ala Ala Ala Leu Leu Ala Arg Ala Pro 
1               5                   10                  15      


Ala Pro Glu Val Cys Ala Ala Leu Asn Val Thr Val Ser Pro Gly Pro 
            20                  25                  30          


Val Val Asp Tyr Leu Glu Gly Glu Asn Ala Thr Leu Leu Cys His Val 
        35                  40                  45              


Ser Gln Lys Arg Arg Lys Asp Ser Leu Leu Ala Val Arg Trp Phe Phe 
    50                  55                  60                  


Ala His Ser Phe Asp Ser Gln Glu Ala Leu Met Val Lys Met Thr Lys 
65                  70                  75                  80  


Leu Arg Val Val Gln Tyr Tyr Gly Asn Phe Ser Arg Ser Ala Lys Arg 
                85                  90                  95      


Arg Arg Leu Arg Leu Leu Glu Glu Gln Arg Gly Ala Leu Tyr Arg Leu 
            100                 105                 110         


Ser Val Leu Thr Leu Gln Pro Ser Asp Gln Gly His Tyr Val Cys Arg 
        115                 120                 125             


Val Gln Glu Ile Ser Arg His Arg Asn Lys Trp Thr Ala Trp Ser Asn 
    130                 135                 140                 


Gly Ser Ser Ala Thr Glu Met Arg Gly Val Ser Ser His Pro Val Glu 
145                 150                 155                 160 


Arg Gly Ala Phe Leu Gly Ile Ser Leu Val Ile Leu Pro His Ser Leu 
                165                 170                 175     


Pro Phe Thr Ala Asp Leu Thr Met Ala Ser Phe Leu Gln Ser Ser 
            180                 185                 190     


<210>  5913
<211>  781
<212>  PRT
<213>  Homo sapiens

<400>  5913

Met Trp Gly Leu Val Arg Leu Leu Leu Ala Trp Leu Gly Gly Trp Gly 
1               5                   10                  15      


Cys Met Gly Arg Leu Ala Ala Pro Ala Arg Ala Trp Ala Gly Ser Arg 
            20                  25                  30          


Glu His Pro Gly Pro Ala Leu Leu Arg Thr Arg Arg Ser Trp Val Trp 
        35                  40                  45              


Asn Gln Phe Phe Val Ile Glu Glu Tyr Ala Gly Pro Glu Pro Val Leu 
    50                  55                  60                  


Ile Gly Lys Leu His Ser Asp Val Asp Arg Gly Glu Gly Arg Thr Lys 
65                  70                  75                  80  


Tyr Leu Leu Thr Gly Glu Gly Ala Gly Thr Val Phe Val Ile Asp Glu 
                85                  90                  95      


Ala Thr Gly Asn Ile His Val Thr Lys Ser Leu Asp Arg Glu Glu Lys 
            100                 105                 110         


Ala Gln Tyr Val Leu Leu Ala Gln Ala Val Asp Arg Ala Ser Asn Arg 
        115                 120                 125             


Pro Leu Glu Pro Pro Ser Glu Phe Ile Ile Lys Val Gln Asp Ile Asn 
    130                 135                 140                 


Asp Asn Pro Pro Ile Phe Pro Leu Gly Pro Tyr His Ala Thr Val Pro 
145                 150                 155                 160 


Glu Met Ser Asn Val Gly Thr Ser Val Ile Gln Val Thr Ala His Asp 
                165                 170                 175     


Ala Asp Asp Pro Ser Tyr Gly Asn Ser Ala Lys Leu Val Tyr Thr Val 
            180                 185                 190         


Leu Asp Gly Leu Pro Phe Phe Ser Val Asp Pro Gln Thr Gly Val Val 
        195                 200                 205             


Arg Thr Ala Ile Pro Asn Met Asp Arg Glu Thr Gln Glu Glu Phe Leu 
    210                 215                 220                 


Val Val Ile Gln Ala Lys Asp Met Gly Gly His Met Gly Gly Leu Ser 
225                 230                 235                 240 


Gly Ser Thr Thr Val Thr Val Thr Leu Ser Asp Val Asn Asp Asn Pro 
                245                 250                 255     


Pro Lys Phe Pro Gln Ser Leu Tyr Gln Phe Ser Val Val Glu Thr Ala 
            260                 265                 270         


Gly Pro Gly Thr Leu Val Gly Arg Leu Arg Ala Gln Asp Pro Asp Leu 
        275                 280                 285             


Gly Asp Asn Ala Leu Met Ala Tyr Ser Ile Leu Asp Gly Glu Gly Ser 
    290                 295                 300                 


Glu Ala Phe Ser Ile Ser Thr Asp Leu Gln Gly Arg Asp Gly Leu Leu 
305                 310                 315                 320 


Thr Val Arg Lys Pro Leu Asp Phe Glu Ser Gln Arg Ser Tyr Ser Phe 
                325                 330                 335     


Arg Val Glu Ala Thr Asn Thr Leu Ile Asp Pro Ala Tyr Leu Arg Arg 
            340                 345                 350         


Gly Pro Phe Lys Asp Val Ala Ser Val Arg Val Ala Val Gln Asp Ala 
        355                 360                 365             


Pro Glu Pro Pro Ala Phe Thr Gln Ala Ala Tyr His Leu Thr Val Pro 
    370                 375                 380                 


Glu Asn Lys Ala Pro Gly Thr Leu Val Gly Gln Ile Ser Ala Ala Asp 
385                 390                 395                 400 


Leu Asp Ser Pro Ala Ser Pro Ile Arg Tyr Ser Ile Leu Pro His Ser 
                405                 410                 415     


Asp Pro Glu Arg Cys Phe Ser Ile Gln Pro Glu Glu Gly Thr Ile His 
            420                 425                 430         


Thr Ala Ala Pro Leu Asp Arg Glu Ala Arg Ala Trp His Asn Leu Thr 
        435                 440                 445             


Val Leu Ala Thr Glu Leu Asp Ser Ser Ala Gln Ala Ser Arg Val Gln 
    450                 455                 460                 


Val Ala Ile Gln Thr Leu Asp Glu Asn Asp Asn Ala Pro Gln Leu Ala 
465                 470                 475                 480 


Glu Pro Tyr Asp Thr Phe Val Cys Asp Ser Ala Ala Pro Gly Gln Leu 
                485                 490                 495     


Ile Gln Val Ile Arg Ala Leu Asp Arg Asp Glu Val Gly Asn Ser Ser 
            500                 505                 510         


His Val Ser Phe Gln Gly Pro Leu Gly Pro Asp Ala Asn Phe Thr Val 
        515                 520                 525             


Gln Asp Asn Arg Asp Gly Ser Ala Ser Leu Leu Leu Pro Ser Arg Pro 
    530                 535                 540                 


Ala Pro Pro Arg His Ala Pro Tyr Leu Val Pro Ile Glu Leu Trp Asp 
545                 550                 555                 560 


Trp Gly Gln Pro Ala Leu Ser Ser Thr Ala Thr Val Thr Val Ser Val 
                565                 570                 575     


Cys Arg Cys Gln Pro Asp Gly Ser Val Ala Ser Cys Trp Pro Glu Ala 
            580                 585                 590         


His Leu Ser Ala Ala Gly Leu Ser Thr Gly Ala Leu Leu Ala Ile Ile 
        595                 600                 605             


Thr Cys Val Gly Ala Leu Leu Ala Leu Val Val Leu Phe Val Ala Leu 
    610                 615                 620                 


Arg Arg Gln Lys Gln Glu Ala Leu Met Val Leu Glu Glu Glu Asp Val 
625                 630                 635                 640 


Arg Glu Asn Ile Ile Thr Tyr Asp Asp Glu Gly Gly Gly Glu Glu Asp 
                645                 650                 655     


Thr Glu Ala Phe Asp Ile Thr Ala Leu Gln Asn Pro Asp Gly Ala Ala 
            660                 665                 670         


Pro Pro Ala Pro Gly Pro Pro Ala Arg Arg Asp Val Leu Pro Arg Ala 
        675                 680                 685             


Arg Val Ser Arg Gln Pro Arg Pro Pro Gly Pro Ala Asp Val Ala Gln 
    690                 695                 700                 


Leu Leu Ala Leu Arg Leu Arg Glu Ala Asp Glu Asp Pro Gly Val Pro 
705                 710                 715                 720 


Pro Tyr Asp Ser Val Gln Val Tyr Gly Tyr Glu Gly Arg Gly Ser Ser 
                725                 730                 735     


Cys Gly Ser Leu Ser Ser Leu Gly Ser Gly Ser Glu Ala Gly Gly Ala 
            740                 745                 750         


Pro Gly Pro Ala Glu Pro Leu Asp Asp Trp Gly Pro Leu Phe Arg Thr 
        755                 760                 765             


Leu Ala Glu Leu Tyr Gly Ala Lys Glu Pro Pro Ala Pro 
    770                 775                 780     


<210>  5914
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  5914

Met Ser Tyr Gly Ser Ile Ala Arg Gly Gly Gly Leu Gly Ser Arg Gly 
1               5                   10                  15      


Pro Phe Gly Gly Pro Ser Arg Gln Gly Cys Gln Pro Leu Glu Cys Ala 
            20                  25                  30          


Arg Cys Trp Thr Glu Tyr Gly Ile Arg His Phe Pro Cys Pro Ser Pro 
        35                  40                  45              


Glu Ser Lys Leu Gln Asn Arg Cys Val Gly Lys Asp Gly Glu Gly Asp 
    50                  55                  60                  


Leu Gly Pro Ala Gly Thr Pro Ile Val Pro Arg Ala Arg Lys Arg Gly 
65                  70                  75                  80  


Pro Gly Val Ala Pro Glu Gly Ser Arg Met Pro Glu Pro Thr Ser Ser 
                85                  90                  95      


Pro Thr Ile Gly Pro Arg Lys Asp Ser Ala Ala Gly Pro His Gly Arg 
            100                 105                 110         


Met Ala Gly Pro Ser Thr Thr Arg Ala Lys Lys Arg Lys Pro Asn Phe 
        115                 120                 125             


Cys Pro Gln Glu Thr Glu Val Leu Val Ser Lys Val Ser Lys His His 
    130                 135                 140                 


Gln Leu Leu Phe Gly Thr Gly Leu Leu Lys Ala Glu Pro Thr Arg Arg 
145                 150                 155                 160 


Tyr Arg Val Trp Ser Arg Ile Leu Gln Ala Val Asn Ala Leu Gly Tyr 
                165                 170                 175     


Cys Arg Arg Asp Val Val Asp Leu Lys His Lys Trp Arg Asp Leu Arg 
            180                 185                 190         


Ala Val Val Arg Arg Lys Leu Gly Asp Leu Arg Lys Ala Ala His Gly 
        195                 200                 205             


Pro Ser Pro Gly Ser Gly Lys Pro Gln Ala Leu Ala Leu Thr Pro Val 
    210                 215                 220                 


Glu Gln Val Val Ala Lys Thr Phe Ser Cys Gln Ala Leu Pro Ser Glu 
225                 230                 235                 240 


Gly Phe Ser Leu Glu Pro Pro Arg Ala Thr Gln Val Asp Pro Cys Asn 
                245                 250                 255     


Leu Gln Glu Leu Phe Gln Glu Met Ser Ala Asn Val Phe Arg Ile Asn 
            260                 265                 270         


Ser Ser Val Thr Ser Leu Glu Arg Ser Leu Gln Ser Leu Gly Thr Pro 
        275                 280                 285             


Ser Asp Thr Gln Glu Leu Arg Asp Ser Leu His Thr Ala Gln Gln Glu 
    290                 295                 300                 


Thr Asn Lys Thr Ile Ala Ala Ser Ala Ser Ser Val Lys Gln Met Ala 
305                 310                 315                 320 


Glu Leu Leu Arg Ser Ser Cys Pro Gln Glu Arg Leu Gln Gln Glu Arg 
                325                 330                 335     


Pro Gln Leu Asp Arg Leu Lys Thr Gln Leu Ser Asp Ala Ile Gln Cys 
            340                 345                 350         


Tyr Gly Val Val Gln Lys Lys Ile Ala Glu Lys Ser Arg Ala Leu Leu 
        355                 360                 365             


Pro Met Ala Gln Arg Gly Ser Lys Gln Ser Pro Gln Ala Pro Phe Ala 
    370                 375                 380                 


Glu Leu Ala Asp Asp Glu Lys Val Phe Asn Gly Ser Asp Asn Met Trp 
385                 390                 395                 400 


Gln Gly Gln Glu Gln Ala Leu Leu Pro Asp Ile Thr Glu Glu Asp Leu 
                405                 410                 415     


Glu Ala Ile Arg Leu Arg Glu Glu Ala Ile Leu Gln Met Glu Ser Asn 
            420                 425                 430         


Leu Leu Asp Val Asn Gln Ile Ile Lys Asp Leu Ala Ser Met Val Ser 
        435                 440                 445             


Glu Gln Gly Glu Ala Val Asp Ser Ile Glu Ala Ser Leu Glu Ala Ala 
    450                 455                 460                 


Ser Ser His Ala Glu Ala Ala Arg Gln Leu Leu Ala Gly Ala Ser Arg 
465                 470                 475                 480 


His Gln Leu Gln Arg His Lys Ile Lys Cys Cys Phe Leu Ser Ala Gly 
                485                 490                 495     


Val Thr Ala Leu Leu Val Ile Ile Ile Ile Ile Ala Thr Ser Val Arg 
            500                 505                 510         


Lys 
    


<210>  5915
<211>  787
<212>  PRT
<213>  Homo sapiens

<400>  5915

Met Phe Arg Leu Trp Leu Leu Leu Ala Gly Leu Cys Gly Leu Leu Ala 
1               5                   10                  15      


Ser Arg Pro Gly Phe Gln Asn Ser Leu Leu Gln Ile Val Ile Pro Glu 
            20                  25                  30          


Lys Ile Gln Thr Asn Thr Asn Asp Ser Ser Glu Ile Glu Tyr Glu Gln 
        35                  40                  45              


Ile Ser Tyr Ile Ile Pro Ile Asp Glu Lys Leu Tyr Thr Val His Leu 
    50                  55                  60                  


Lys Gln Arg Tyr Phe Leu Ala Asp Asn Phe Met Ile Tyr Leu Tyr Asn 
65                  70                  75                  80  


Gln Gly Ser Met Asn Thr Tyr Ser Ser Asp Ile Gln Thr Gln Cys Tyr 
                85                  90                  95      


Tyr Gln Gly Asn Ile Glu Gly Tyr Pro Asp Ser Met Val Thr Leu Ser 
            100                 105                 110         


Thr Cys Ser Gly Leu Arg Gly Ile Leu Gln Phe Glu Asn Val Ser Tyr 
        115                 120                 125             


Gly Ile Glu Pro Leu Glu Ser Ala Val Glu Phe Gln His Val Leu Tyr 
    130                 135                 140                 


Lys Leu Lys Asn Glu Asp Asn Asp Ile Ala Ile Phe Ile Asp Arg Ser 
145                 150                 155                 160 


Leu Lys Glu Gln Pro Met Asp Asp Asn Ile Phe Ile Ser Glu Lys Ser 
                165                 170                 175     


Glu Pro Ala Val Pro Asp Leu Phe Pro Leu Tyr Leu Glu Met His Ile 
            180                 185                 190         


Val Val Asp Lys Thr Leu Tyr Asp Tyr Trp Gly Ser Asp Ser Met Ile 
        195                 200                 205             


Val Thr Asn Lys Val Ile Glu Ile Val Gly Leu Ala Asn Ser Met Phe 
    210                 215                 220                 


Thr Gln Phe Lys Val Thr Ile Val Leu Ser Ser Leu Glu Leu Trp Ser 
225                 230                 235                 240 


Asp Glu Asn Lys Ile Ser Thr Val Gly Glu Ala Asp Glu Leu Leu Gln 
                245                 250                 255     


Lys Phe Leu Glu Trp Lys Gln Ser Tyr Leu Asn Leu Arg Pro His Asp 
            260                 265                 270         


Ile Ala Tyr Leu Leu Ile Tyr Met Asp Tyr Pro Arg Tyr Leu Gly Ala 
        275                 280                 285             


Val Phe Pro Gly Thr Met Cys Ile Thr Arg Tyr Ser Ala Gly Val Ala 
    290                 295                 300                 


Leu Tyr Pro Lys Glu Ile Thr Leu Glu Ala Phe Ala Val Ile Val Thr 
305                 310                 315                 320 


Gln Met Leu Ala Leu Ser Leu Gly Ile Ser Tyr Asp Asp Pro Lys Lys 
                325                 330                 335     


Cys Gln Cys Ser Glu Ser Thr Cys Ile Met Asn Pro Glu Val Val Gln 
            340                 345                 350         


Ser Asn Gly Val Lys Thr Phe Ser Ser Cys Ser Leu Arg Ser Phe Gln 
        355                 360                 365             


Asn Phe Ile Ser Asn Val Gly Val Lys Cys Leu Gln Asn Lys Pro Gln 
    370                 375                 380                 


Met Gln Lys Lys Ser Pro Lys Pro Val Cys Gly Asn Gly Arg Leu Glu 
385                 390                 395                 400 


Gly Asn Glu Ile Cys Asp Cys Gly Thr Glu Ala Gln Cys Gly Pro Ala 
                405                 410                 415     


Ser Cys Cys Asp Phe Arg Thr Cys Val Leu Lys Asp Gly Ala Lys Cys 
            420                 425                 430         


Tyr Lys Gly Leu Cys Cys Lys Asp Cys Gln Ile Leu Gln Ser Gly Val 
        435                 440                 445             


Glu Cys Arg Pro Lys Ala His Pro Glu Cys Asp Ile Ala Glu Asn Cys 
    450                 455                 460                 


Asn Gly Ser Ser Pro Glu Cys Gly Pro Asp Ile Thr Leu Ile Asn Gly 
465                 470                 475                 480 


Leu Ser Cys Lys Asn Asn Lys Phe Ile Cys Tyr Asp Gly Asp Cys His 
                485                 490                 495     


Asp Leu Asp Ala Arg Cys Glu Ser Val Phe Gly Lys Gly Ser Arg Asn 
            500                 505                 510         


Ala Pro Phe Ala Cys Tyr Glu Glu Ile Gln Ser Gln Ser Asp Arg Phe 
        515                 520                 525             


Gly Asn Cys Gly Arg Asp Arg Asn Asn Lys Tyr Val Phe Cys Gly Trp 
    530                 535                 540                 


Arg Asn Leu Ile Cys Gly Arg Leu Val Cys Thr Tyr Pro Thr Arg Lys 
545                 550                 555                 560 


Pro Phe His Gln Glu Asn Gly Asp Val Ile Tyr Ala Phe Val Arg Asp 
                565                 570                 575     


Ser Val Cys Ile Thr Val Asp Tyr Lys Leu Pro Arg Thr Val Pro Asp 
            580                 585                 590         


Pro Leu Ala Val Lys Asn Gly Ser Gln Cys Asp Ile Gly Arg Val Cys 
        595                 600                 605             


Val Asn Arg Glu Cys Val Glu Ser Arg Ile Ile Lys Ala Ser Ala His 
    610                 615                 620                 


Val Cys Ser Gln Gln Cys Ser Gly His Gly Val Cys Asp Ser Arg Asn 
625                 630                 635                 640 


Lys Cys His Cys Ser Pro Gly Tyr Lys Pro Pro Asn Cys Gln Ile Arg 
                645                 650                 655     


Ser Lys Gly Phe Ser Ile Phe Pro Glu Glu Asp Met Gly Ser Ile Met 
            660                 665                 670         


Glu Arg Ala Ser Gly Lys Thr Glu Asn Thr Trp Leu Leu Gly Phe Leu 
        675                 680                 685             


Ile Ala Leu Pro Ile Leu Ile Val Thr Thr Ala Ile Val Leu Ala Arg 
    690                 695                 700                 


Lys Gln Leu Lys Lys Trp Phe Ala Lys Glu Glu Glu Phe Pro Ser Ser 
705                 710                 715                 720 


Glu Ser Lys Ser Glu Gly Ser Thr Gln Thr Tyr Ala Ser Gln Ser Ser 
                725                 730                 735     


Ser Glu Gly Ser Thr Gln Thr Tyr Ala Ser Gln Thr Arg Ser Glu Ser 
            740                 745                 750         


Ser Ser Gln Ala Asp Thr Ser Lys Ser Lys Ser Glu Asp Ser Ala Glu 
        755                 760                 765             


Ala Tyr Thr Ser Arg Ser Lys Ser Gln Asp Ser Thr Gln Thr Gln Ser 
    770                 775                 780                 


Ser Ser Asn 
785         


<210>  5916
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  5916

Met Arg Trp Ala Ala Ala Thr Leu Arg Gly Lys Ala Arg Pro Arg Gly 
1               5                   10                  15      


Arg Ala Gly Val Thr Thr Pro Ala Pro Gly Asn Arg Thr Gly Thr Cys 
            20                  25                  30          


Ala Lys Leu Arg Leu Pro Pro Gln Ala Thr Phe Gln Val Leu Arg Gly 
        35                  40                  45              


Asn Gly Ala Ser Val Gly Thr Val Leu Met Phe Arg Cys Pro Ser Asn 
    50                  55                  60                  


His Gln Met Val Gly Ser Gly Leu Leu Thr Cys Thr Trp Lys Gly Ser 
65                  70                  75                  80  


Ile Ala Glu Trp Ser Ser Gly Ser Pro Val Cys Lys Leu Val Pro Pro 
                85                  90                  95      


His Glu Thr Phe Gly Phe Lys Val Ala Val Ile Ala Ser Ile Val Ser 
            100                 105                 110         


Cys Ala Ile Ile Leu Leu Met Ser Met Ala Phe Leu Thr Cys Cys Leu 
        115                 120                 125             


Leu Lys Cys Val Lys Lys Ser Lys Arg Arg Arg Ser Asn Arg Ser Ala 
    130                 135                 140                 


Gln Leu Trp Ser Gln Leu Lys Asp Glu Asp Leu Glu Thr Val Gln Ala 
145                 150                 155                 160 


Ala Tyr Leu Gly Leu Lys His Phe Asn Lys Pro Val Ser Gly Pro Ser 
                165                 170                 175     


Gln Ala His Asp Asn His Ser Phe Thr Thr Asp His Gly Glu Ser Thr 
            180                 185                 190         


Ser Lys Leu Ala Ser Val Thr Arg Ser Val Asp Lys Asp Pro Gly Ile 
        195                 200                 205             


Pro Arg Ala Leu Ser Leu Ser Gly Ser Ser Ser Ser Pro Gln Ala Gln 
    210                 215                 220                 


Val Met Val His Met Ala Asn Pro Arg Gln Pro Leu Pro Ala Ser Gly 
225                 230                 235                 240 


Leu Ala Thr Gly Met Pro Gln Gln Pro Ala Ala Tyr Ala Leu Gly 
                245                 250                 255 


<210>  5917
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  5917

Met Ala Gly Asn Cys Ser Trp Glu Ala His Pro Gly Asn Arg Asn Lys 
1               5                   10                  15      


Met Cys Pro Gly Leu Ser Glu Ala Pro Glu Leu Tyr Ser Arg Gly Phe 
            20                  25                  30          


Leu Thr Ile Glu Gln Ile Ala Met Leu Pro Pro Pro Ala Val Met Asn 
        35                  40                  45              


Tyr Ile Phe Leu Leu Leu Cys Leu Cys Gly Leu Val Gly Asn Gly Leu 
    50                  55                  60                  


Val Leu Trp Phe Phe Gly Phe Ser Ile Lys Arg Asn Pro Phe Ser Ile 
65                  70                  75                  80  


Tyr Phe Leu His Leu Ala Ser Ala Asp Val Gly Tyr Leu Phe Ser Lys 
                85                  90                  95      


Ala Val Phe Ser Ile Leu Asn Thr Gly Gly Phe Leu Gly Thr Phe Ala 
            100                 105                 110         


Asp Tyr Ile Arg Ser Val Cys Arg Val Leu Gly Leu Cys Met Phe Leu 
        115                 120                 125             


Thr Gly Val Ser Leu Leu Pro Ala Val Ser Ala Glu Arg Cys Ala Ser 
    130                 135                 140                 


Val Ile Phe Pro Ala Trp Tyr Trp Arg Arg Arg Pro Lys Arg Leu Ser 
145                 150                 155                 160 


Ala Val Val Cys Ala Leu Leu Trp Val Leu Ser Leu Leu Val Thr Cys 
                165                 170                 175     


Leu His Asn Tyr Phe Cys Val Phe Leu Gly Arg Gly Ala Pro Gly Ala 
            180                 185                 190         


Ala Cys Arg His Met Asp Ile Phe Leu Gly Ile Leu Leu Phe Leu Leu 
        195                 200                 205             


Cys Cys Pro Leu Met Val Leu Pro Cys Leu Ala Leu Ile Leu His Val 
    210                 215                 220                 


Glu Cys Arg Ala Arg Arg Arg Gln Arg Ser Ala Lys Leu Asn His Val 
225                 230                 235                 240 


Ile Leu Ala Met Val Ser Val Phe Leu Val Ser Ser Ile Tyr Leu Gly 
                245                 250                 255     


Ile Asp Trp Phe Leu Phe Trp Val Phe Gln Ile Pro Ala Pro Phe Pro 
            260                 265                 270         


Glu Tyr Val Thr Asp Leu Cys Ile Cys Ile Asn Ser Ser Ala Lys Pro 
        275                 280                 285             


Ile Val Tyr Phe Leu Ala Gly Arg Asp Lys Ser Gln Arg Leu Trp Glu 
    290                 295                 300                 


Pro Leu Arg Val Val Phe Gln Arg Ala Leu Arg Asp Gly Ala Glu Leu 
305                 310                 315                 320 


Gly Glu Ala Gly Gly Ser Thr Pro Asn Thr Val Thr Met Glu Met Gln 
                325                 330                 335     


Cys Pro Pro Gly Asn Ala Ser 
            340             


<210>  5918
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  5918

Met Ser Met Pro Leu His Gln Ile Ser Ala Ile Pro Ser Gln Asp Ala 
1               5                   10                  15      


Ile Ser Ala Arg Val Tyr Arg Ser Lys Thr Lys Glu Lys Glu Arg Glu 
            20                  25                  30          


Glu Gln Asn Glu Lys Thr Leu Gly His Phe Met Ser His Ser Ser Asn 
        35                  40                  45              


Ile Ser Lys Ala Gly Ser Pro Pro Ser Ala Ser Ala Pro Ala Pro Val 
    50                  55                  60                  


Ser Ser Phe Ser Arg Thr Ser Ile Thr Pro Ser Ser Gln Asp Ile Cys 
65                  70                  75                  80  


Arg Ile Cys His Cys Glu Gly Asp Asp Glu Ser Pro Leu Ile Thr Pro 
                85                  90                  95      


Cys His Cys Thr Gly Ser Leu His Phe Val His Gln Ala Cys Leu Gln 
            100                 105                 110         


Gln Trp Ile Lys Ser Ser Asp Thr Arg Cys Cys Glu Leu Cys Lys Tyr 
        115                 120                 125             


Glu Phe Ile Met Glu Thr Lys Leu Lys Pro Leu Arg Lys Trp Glu Lys 
    130                 135                 140                 


Leu Gln Met Thr Ser Ser Glu Arg Arg Lys Ile Met Cys Ser Val Thr 
145                 150                 155                 160 


Phe His Val Ile Ala Ile Thr Cys Val Val Trp Ser Leu Tyr Val Leu 
                165                 170                 175     


Ile Asp Arg Thr Ala Glu Glu Ile Lys Gln Gly Gln Ala Thr Gly Ile 
            180                 185                 190         


Leu Glu Trp Pro Phe Trp Thr Lys Leu Val Val Val Ala Ile Gly Phe 
        195                 200                 205             


Thr Gly Gly Leu Leu Phe Met Tyr Val Gln Cys Lys Val Tyr Val Gln 
    210                 215                 220                 


Leu Trp Lys Arg Leu Lys Ala Tyr Asn Arg Val Ile Tyr Val Gln Asn 
225                 230                 235                 240 


Cys Pro Glu Thr Ser Lys Lys Asn Ile Phe Glu Lys Ser Pro Leu Thr 
                245                 250                 255     


Glu Pro Asn Phe Glu Asn Lys His Gly Tyr Gly Ile Cys His Ser Asp 
            260                 265                 270         


Thr Asn Ser Ser Cys Cys Thr Glu Pro Glu Asp Thr Gly Ala Glu Ile 
        275                 280                 285             


Ile His Val 
    290     


<210>  5919
<211>  525
<212>  PRT
<213>  Homo sapiens

<400>  5919

Met Ser Gly Asn Trp Val His Pro Gly Gln Ile Leu Ile Trp Ala Ile 
1               5                   10                  15      


Trp Val Leu Ala Ala Pro Thr Lys Gly Pro Ser Ala Glu Gly Pro Gln 
            20                  25                  30          


Arg Asn Thr Arg Leu Gly Trp Ile Gln Gly Lys Gln Val Thr Val Leu 
        35                  40                  45              


Gly Ser Pro Val Pro Val Asn Val Phe Leu Gly Val Pro Phe Ala Ala 
    50                  55                  60                  


Pro Pro Leu Gly Ser Leu Arg Phe Thr Asn Pro Gln Pro Ala Ser Pro 
65                  70                  75                  80  


Trp Asp Asn Leu Arg Glu Ala Thr Ser Tyr Pro Asn Leu Cys Leu Gln 
                85                  90                  95      


Asn Ser Glu Trp Leu Leu Leu Asp Gln His Met Leu Lys Val His Tyr 
            100                 105                 110         


Pro Lys Phe Gly Val Ser Glu Asp Cys Leu Tyr Leu Asn Ile Tyr Ala 
        115                 120                 125             


Pro Ala His Ala Asp Thr Gly Ser Lys Leu Pro Val Leu Val Trp Phe 
    130                 135                 140                 


Pro Gly Gly Ala Phe Lys Thr Gly Ser Ala Ser Ile Phe Asp Gly Ser 
145                 150                 155                 160 


Ala Leu Ala Ala Tyr Glu Asp Val Leu Val Val Val Val Gln Tyr Arg 
                165                 170                 175     


Leu Gly Ile Phe Gly Phe Phe Thr Thr Trp Asp Gln His Ala Pro Gly 
            180                 185                 190         


Asn Trp Ala Phe Lys Asp Gln Val Ala Ala Leu Ser Trp Val Gln Lys 
        195                 200                 205             


Asn Ile Glu Phe Phe Gly Gly Asp Pro Ser Ser Val Thr Ile Phe Gly 
    210                 215                 220                 


Glu Ser Ala Gly Ala Ile Ser Val Ser Ser Leu Ile Leu Ser Pro Met 
225                 230                 235                 240 


Ala Lys Gly Leu Phe His Lys Ala Ile Met Glu Ser Gly Val Ala Ile 
                245                 250                 255     


Ile Pro Tyr Leu Glu Ala His Asp Tyr Glu Lys Ser Glu Asp Leu Gln 
            260                 265                 270         


Val Val Ala His Phe Cys Gly Asn Asn Ala Ser Asp Ser Glu Ala Leu 
        275                 280                 285             


Leu Arg Cys Leu Arg Thr Lys Pro Ser Lys Glu Leu Leu Thr Leu Ser 
    290                 295                 300                 


Gln Lys Thr Lys Ser Phe Thr Arg Val Val Asp Gly Ala Phe Phe Pro 
305                 310                 315                 320 


Asn Glu Pro Leu Asp Leu Leu Ser Gln Lys Ala Phe Lys Ala Ile Pro 
                325                 330                 335     


Ser Ile Ile Gly Val Asn Asn His Glu Cys Gly Phe Leu Leu Pro Met 
            340                 345                 350         


Lys Glu Ala Pro Glu Ile Leu Ser Gly Ser Asn Lys Ser Leu Ala Leu 
        355                 360                 365             


His Leu Ile Gln Asn Ile Leu His Ile Pro Pro Gln Tyr Leu His Leu 
    370                 375                 380                 


Val Ala Asn Glu Tyr Phe His Asp Lys His Ser Leu Thr Glu Ile Arg 
385                 390                 395                 400 


Asp Ser Leu Leu Asp Leu Leu Gly Asp Val Phe Phe Val Val Pro Ala 
                405                 410                 415     


Leu Ile Thr Ala Arg Tyr His Arg Glu Gly Ala Thr Glu Glu Glu Lys 
            420                 425                 430         


Leu Leu Ser Arg Lys Met Met Lys Tyr Trp Ala Thr Phe Ala Arg Thr 
        435                 440                 445             


Gly Asn Pro Asn Gly Asn Asp Leu Ser Leu Trp Pro Ala Tyr Asn Leu 
    450                 455                 460                 


Thr Glu Gln Tyr Leu Gln Leu Asp Leu Asn Met Ser Leu Gly Gln Arg 
465                 470                 475                 480 


Leu Lys Glu Pro Arg Val Asp Phe Trp Thr Ser Thr Ile Pro Leu Ile 
                485                 490                 495     


Leu Ser Ala Ser Asp Met Leu His Ser Pro Leu Ser Ser Leu Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Gln Pro Phe Phe Phe Phe Cys Ala Pro 
        515                 520                 525 


<210>  5920
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  5920

Met Tyr Gln Pro Ser Arg Gly Ala Ala Arg Arg Leu Gly Pro Cys Leu 
1               5                   10                  15      


Arg Ala Tyr Gln Ala Arg Pro Gln Leu Pro Lys Leu Phe Leu Gln Ser 
            20                  25                  30          


His Asp Tyr Ser Leu Tyr Ser Leu Asp Val Glu Phe Ile Asn Glu Ile 
        35                  40                  45              


Leu Asn Ile Arg Thr Lys Gly Arg Thr Trp Tyr Ile Leu Ser Leu Thr 
    50                  55                  60                  


Leu Cys Arg Phe Leu Ala Trp Asn Tyr Phe Ala His Leu Arg Leu Glu 
65                  70                  75                  80  


Val Leu Gln Leu Thr Arg His Pro Glu Asn Trp Thr Leu Gln Ala Arg 
                85                  90                  95      


Trp Arg Leu Val Gly Leu Pro Val His Leu Leu Phe Leu Arg Phe Tyr 
            100                 105                 110         


Lys Arg Asp Lys Asp Glu His Tyr Arg Thr Tyr Asp Ala Tyr Ser Thr 
        115                 120                 125             


Phe Tyr Leu Asn Ser Ser Gly Leu Ile Cys Arg His Arg Leu Asp Lys 
    130                 135                 140                 


Leu Met Pro Ser His Ser Pro Pro Thr Pro Val Lys Lys Leu Leu Val 
145                 150                 155                 160 


Gly Ala Leu Val Ala Leu Gly Leu Ser Glu Pro Glu Pro Asp Leu Asn 
                165                 170                 175     


Leu Cys Ser Lys Pro 
            180     


<210>  5921
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  5921

Met Ala Asp Ser Gly Leu Arg Glu Pro Gln Glu Asp Ser Gln Lys Asp 
1               5                   10                  15      


Leu Glu Asn Asp Pro Ser Val Asn Ser Gln Ala Gln Glu Thr Thr Ile 
            20                  25                  30          


Ile Ala Ser Asn Ala Glu Glu Ala Glu Ile Leu His Ser Ala Cys Gly 
        35                  40                  45              


Leu Ser Lys Asp His Gln Glu Val Glu Thr Glu Gly Pro Glu Ser Ala 
    50                  55                  60                  


Asp Thr Gly Asp Lys Ser Glu Ser Pro Asp Glu Ala Asn Val Gly Lys 
65                  70                  75                  80  


His Pro Lys Asp Lys Thr Glu Asp Glu Asn Lys Gln Ser Phe Leu Asp 
                85                  90                  95      


Gly Gly Lys Gly His His Leu Pro Ser Glu Asn Leu Gly Lys Glu Pro 
            100                 105                 110         


Leu Asp Pro Asp Pro Ser His Ser Pro Ser Asp Lys Val Gly Arg Ala 
        115                 120                 125             


Asp Ala His Leu Gly Ser Ser Ser Val Ala Leu Pro Lys Glu Ala Ser 
    130                 135                 140                 


Asp Gly Thr Gly Ala Ser Gln Glu Pro Pro Thr Thr Asp Ser Gln Glu 
145                 150                 155                 160 


Ala Gln Ser Pro Gly His Ser Ser Ala Gly Gln Glu Gly Glu Asp Thr 
                165                 170                 175     


Leu Arg Arg Arg Leu Leu Ala Pro Glu Ala Gly Ser His Pro Gln Gln 
            180                 185                 190         


Thr Gln Lys Leu Glu Glu Ile Lys Glu Asn Ala Gln Asp Thr Met Arg 
        195                 200                 205             


Gln Ile Asn Lys Lys Gly Phe Trp Ser Tyr Gly Pro Val Ile Leu Val 
    210                 215                 220                 


Val Leu Val Val Ala Val Val Ala Ser Ser Val Asn Ser Tyr Tyr Ser 
225                 230                 235                 240 


Ser Pro Ala Gln Gln Val Pro Lys Asn Pro Ala Leu Glu Ala Phe Leu 
                245                 250                 255     


Ala Gln Phe Ser Gln Leu Glu Asp Lys Phe Pro Gly Gln Ser Ser Phe 
            260                 265                 270         


Leu Trp Gln Arg Gly Arg Lys Phe Leu Gln Lys His Leu Asn Ala Ser 
        275                 280                 285             


Asn Pro Thr Glu Pro Ala Thr Ile Ile Phe Thr Ala Ala Arg Glu Gly 
    290                 295                 300                 


Arg Glu Thr Leu Lys Cys Leu Ser His His Val Ala Asp Ala Tyr Thr 
305                 310                 315                 320 


Ser Ser Gln Lys Val Ser Pro Ile Gln Ile Asp Gly Ala Gly Arg Thr 
                325                 330                 335     


Trp Gln Asp Ser Asp Thr Val Lys Leu Leu Val Asp Leu Glu Leu Ser 
            340                 345                 350         


Tyr Gly Phe Glu Asn Gly Gln Lys Ala Ala Val Val His His Phe Glu 
        355                 360                 365             


Ser Phe Pro Ala Gly Ser Thr Leu Ile Phe Tyr Lys Tyr Cys Asp His 
    370                 375                 380                 


Glu Asn Ala Ala Phe Lys Asp Val Ala Leu Val Leu Thr Val Leu Leu 
385                 390                 395                 400 


Glu Glu Glu Thr Leu Glu Ala Ser Val Gly Pro Arg Glu Thr Glu Glu 
                405                 410                 415     


Lys Val Arg Asp Leu Leu Trp Ala Lys Phe Thr Asn Ser Asp Thr Pro 
            420                 425                 430         


Thr Ser Phe Asn His Met Asp Ser Asp Lys Leu Ser Gly Leu Trp Ser 
        435                 440                 445             


Arg Ile Ser His Leu Val Leu Pro Val Gln Pro Val Ser Ser Ile Glu 
    450                 455                 460                 


Glu Gln Gly Cys Leu Phe 
465                 470 


<210>  5922
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  5922

Met Trp Thr Asn Phe Phe Lys Leu Arg Leu Phe Cys Cys Leu Leu Ala 
1               5                   10                  15      


Val Leu Met Val Val Val Leu Val Ile Asn Val Thr Gln Val Glu Tyr 
            20                  25                  30          


Leu Asp His Glu Thr Val Ser Ala Thr Phe Ile Asp Ser Ser Gly Gln 
        35                  40                  45              


Phe Val Ser Ser Gln Val Thr Gly Ile Ser Arg Asn Pro Tyr Cys Gly 
    50                  55                  60                  


Tyr Asp Gln Gln Thr Leu Ser Ser Gln Glu Arg Met Glu Glu Asp Ser 
65                  70                  75                  80  


Leu Leu Ala Ala Leu His Arg Gln Val Pro Asp Val Gly Pro Val Pro 
                85                  90                  95      


Phe Val Lys Ser Thr Asp Pro Ser Ser Ser Tyr Phe Val Ile Leu Asn 
            100                 105                 110         


Ser Ala Ala Phe Phe Lys Val Gly Ser Gln Leu Glu Val Leu Val His 
        115                 120                 125             


Val Gln Asp Phe Gln Arg Lys Pro Lys Lys Tyr Gly Gly Asp Tyr Leu 
    130                 135                 140                 


Gln Ala Arg Ile His Ser Leu Lys Leu Gln Ala Gly Ala Val Gly Arg 
145                 150                 155                 160 


Val Val Asp Tyr Gln Asn Gly Phe Tyr Lys Val Phe Phe Thr Leu Leu 
                165                 170                 175     


Trp Pro Gly Lys Val Lys Val Ser Val Ser Leu Val His Pro Ser Glu 
            180                 185                 190         


Gly Ile Arg Val Leu Gln Arg Leu Gln Glu Asp Lys Pro Asp Arg Val 
        195                 200                 205             


Tyr Phe Lys Ser Leu Phe Arg Ser Gly Arg Ile Ser Glu Thr Thr Glu 
    210                 215                 220                 


Cys Asn Val Cys Leu Pro Gly Asn Leu Pro Leu Cys Asn Phe Thr Asp 
225                 230                 235                 240 


Leu Tyr Thr Gly Glu Pro Trp Phe Cys Phe Lys Pro Lys Lys Leu Pro 
                245                 250                 255     


Cys Ser Ser Arg Ile Thr His Phe Lys Gly Gly Tyr Leu Lys Gly Leu 
            260                 265                 270         


Leu Thr Ala Ala Glu Ser Ala Phe Phe Gln Ser Gly Val Asn Ile Lys 
        275                 280                 285             


Met Pro Val Asn Ser Ser Gly Pro Asp Trp Val Thr Val Ile Pro Arg 
    290                 295                 300                 


Arg Ile Lys Glu Thr Asn Ser Leu Glu Leu Ser Gln Gly Ser Gly Thr 
305                 310                 315                 320 


Phe Pro Ser Gly Tyr Tyr Tyr Lys Asp Gln Trp Arg Pro Arg Lys Phe 
                325                 330                 335     


Lys Met Arg Gln Phe Asn Asp Pro Asp Asn Ile Thr Glu Cys Leu Gln 
            340                 345                 350         


Arg Lys Val Val His Leu Phe Gly Asp Ser Thr Ile Arg Gln Trp Phe 
        355                 360                 365             


Glu Tyr Leu Thr Thr Phe Val Pro Asp Leu Val Glu Phe Asn Leu Gly 
    370                 375                 380                 


Ser Pro Lys Asn Val Gly Pro Phe Leu Ala Val Asp Gln Lys His Asn 
385                 390                 395                 400 


Ile Leu Leu Lys Tyr Arg Cys His Gly Pro Pro Ile Arg Phe Thr Thr 
                405                 410                 415     


Val Phe Ser Asn Glu Leu His Tyr Val Ala Asn Glu Leu Asn Gly Ile 
            420                 425                 430         


Val Gly Gly Lys Asn Thr Val Val Ala Ile Ala Val Trp Ser His Phe 
        435                 440                 445             


Ser Thr Phe Pro Leu Glu Val Tyr Ile Arg Arg Leu Arg Asn Ile Arg 
    450                 455                 460                 


Arg Ala Val Val Arg Leu Leu Asp Arg Ser Pro Lys Thr Val Val Val 
465                 470                 475                 480 


Ile Arg Thr Ala Asn Ala Gln Glu Leu Gly Pro Glu Val Ser Leu Phe 
                485                 490                 495     


Asn Ser Asp Trp Tyr Asn Phe Gln Leu Asp Thr Ile Leu Arg Arg Met 
            500                 505                 510         


Phe Ser Gly Val Gly Val Tyr Leu Val Asp Ala Trp Glu Met Thr Leu 
        515                 520                 525             


Ala His Tyr Leu Pro His Lys Leu His Pro Asp Glu Val Ile Val Lys 
    530                 535                 540                 


Asn Gln Leu Asp Met Phe Leu Ser Phe Val Cys Pro Leu Glu Thr 
545                 550                 555                 


<210>  5923
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  5923

Met Gly Lys Thr Phe Ser Gln Leu Gly Ser Trp Arg Glu Asp Glu Asn 
1               5                   10                  15      


Lys Ser Ile Leu Ser Ser Lys Pro Ala Ile Gly Ser Lys Ala Val Asn 
            20                  25                  30          


Tyr Ser Ser Thr Gly Ser Ser Lys Ser Phe Cys Ser Cys Val Pro Cys 
        35                  40                  45              


Glu Gly Thr Ala Asp Ala Ser Phe Val Thr Cys Pro Thr Cys Gln Gly 
    50                  55                  60                  


Ser Gly Lys Ile Pro Gln Glu Leu Glu Lys Gln Leu Val Ala Leu Ile 
65                  70                  75                  80  


Pro Tyr Gly Asp Gln Arg Leu Lys Pro Lys His Thr Lys Leu Phe Val 
                85                  90                  95      


Phe Leu Ala Val Leu Ile Cys Leu Val Thr Ser Ser Phe Ile Val Phe 
            100                 105                 110         


Phe Leu Phe Pro Arg Ser Val Ile Val Gln Pro Ala Gly Leu Asn Ser 
        115                 120                 125             


Ser Thr Val Ala Phe Asp Glu Ala Asp Ile Tyr Leu Asn Ile Thr Asn 
    130                 135                 140                 


Ile Leu Asn Ile Ser Asn Gly Asn Tyr Tyr Pro Ile Met Val Thr Gln 
145                 150                 155                 160 


Leu Thr Leu Glu Val Leu His Leu Ser Leu Val Val Gly Gln Val Ser 
                165                 170                 175     


Asn Asn Leu Leu Leu His Ile Gly Pro Leu Ala Ser Glu Gln Met Phe 
            180                 185                 190         


Tyr Ala Val Ala Thr Lys Ile Arg Asp Glu Asn Thr Tyr Lys Ile Cys 
        195                 200                 205             


Thr Trp Leu Glu Ile Lys Val His His Val Leu Leu His Ile Gln Gly 
    210                 215                 220                 


Thr Leu Thr Cys Ser Tyr Leu Ser His Ser Glu Gln Leu Val Phe Gln 
225                 230                 235                 240 


Ser Tyr Glu Tyr Val Asp Cys Arg Gly Asn Ala Ser Val Pro His Gln 
                245                 250                 255     


Leu Thr Pro His Pro Pro 
            260         


<210>  5924
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  5924

Met Ala Glu Gln Gln Gly Arg Glu Leu Glu Ala Glu Cys Pro Val Cys 
1               5                   10                  15      


Trp Asn Pro Phe Asn Asn Thr Phe His Thr Pro Lys Met Leu Asp Cys 
            20                  25                  30          


Cys His Ser Phe Cys Val Glu Cys Leu Ala His Leu Ser Leu Val Thr 
        35                  40                  45              


Pro Ala Arg Arg Arg Leu Leu Cys Pro Leu Cys Arg Gln Pro Thr Val 
    50                  55                  60                  


Leu Ala Ser Gly Gln Pro Val Thr Asp Leu Pro Thr Asp Thr Ala Met 
65                  70                  75                  80  


Leu Ala Leu Leu Arg Leu Glu Pro His His Val Ile Leu Glu Gly His 
                85                  90                  95      


Gln Leu Cys Leu Lys Asp Gln Pro Lys Ser Arg Tyr Phe Leu Arg Gln 
            100                 105                 110         


Pro Gln Val Tyr Thr Leu Asp Leu Gly Pro Gln Pro Gly Gly Gln Thr 
        115                 120                 125             


Gly Pro Pro Pro Asp Thr Ala Ser Ala Thr Val Ser Thr Pro Ile Leu 
    130                 135                 140                 


Ile Pro Ser His His Ser Leu Arg Glu Cys Phe Arg Asn Pro Gln Phe 
145                 150                 155                 160 


Arg Ile Phe Ala Tyr Leu Met Ala Val Ile Leu Ser Val Thr Leu Leu 
                165                 170                 175     


Leu Ile Phe Ser Ile Phe Trp Thr Lys Gln Phe Leu Trp Gly Val Gly 
            180                 185                 190         


<210>  5925
<211>  790
<212>  PRT
<213>  Homo sapiens

<400>  5925

Met Lys Ala His Pro Lys Glu Met Val Pro Leu Met Gly Lys Arg Val 
1               5                   10                  15      


Ala Ala Pro Ser Gly Asn Pro Ala Ile Leu Pro Glu Lys Arg Pro Ala 
            20                  25                  30          


Glu Ile Thr Pro Thr Lys Lys Ser Ala His Phe Phe Leu Glu Ile Glu 
        35                  40                  45              


Gly Phe Glu Pro Asn Pro Thr Val Ala Lys Thr Ser Pro Pro Val Phe 
    50                  55                  60                  


Ser Lys Pro Met Asp Ser Asn Ile Arg Gln Cys Ile Ser Gly Asn Cys 
65                  70                  75                  80  


Asp Asp Met Asp Ser Pro Gln Ser Pro Gln Asp Asp Val Thr Glu Thr 
                85                  90                  95      


Pro Ser Asn Pro Asn Ser Pro Ser Ala Gln Leu Ala Lys Glu Glu Gln 
            100                 105                 110         


Arg Arg Lys Lys Arg Arg Leu Lys Lys Arg Ile Phe Ala Ala Val Ser 
        115                 120                 125             


Glu Gly Cys Val Glu Glu Leu Val Glu Leu Leu Val Glu Leu Gln Glu 
    130                 135                 140                 


Leu Cys Arg Arg Arg His Asp Glu Asp Val Pro Asp Phe Leu Met His 
145                 150                 155                 160 


Lys Leu Thr Ala Ser Asp Thr Gly Lys Thr Cys Leu Met Lys Ala Leu 
                165                 170                 175     


Leu Asn Ile Asn Pro Asn Thr Lys Glu Ile Val Arg Ile Leu Leu Ala 
            180                 185                 190         


Phe Ala Glu Glu Asn Asp Ile Leu Gly Arg Phe Ile Asn Ala Glu Tyr 
        195                 200                 205             


Thr Glu Glu Ala Tyr Glu Gly Gln Thr Ala Leu Asn Ile Ala Ile Glu 
    210                 215                 220                 


Arg Arg Gln Gly Asp Ile Ala Ala Leu Leu Ile Ala Ala Gly Ala Asp 
225                 230                 235                 240 


Val Asn Ala His Ala Lys Gly Ala Phe Phe Asn Pro Lys Tyr Gln His 
                245                 250                 255     


Glu Gly Phe Tyr Phe Gly Glu Thr Pro Leu Ala Leu Ala Ala Cys Thr 
            260                 265                 270         


Asn Gln Pro Glu Ile Val Gln Leu Leu Met Glu His Glu Gln Thr Asp 
        275                 280                 285             


Ile Thr Ser Arg Asp Ser Arg Gly Asn Asn Ile Leu His Ala Leu Val 
    290                 295                 300                 


Thr Val Ala Glu Asp Phe Lys Thr Gln Asn Asp Phe Val Lys Arg Met 
305                 310                 315                 320 


Tyr Asp Met Ile Leu Leu Arg Ser Gly Asn Trp Glu Leu Glu Thr Thr 
                325                 330                 335     


Arg Asn Asn Asp Gly Leu Thr Pro Leu Gln Leu Ala Ala Lys Met Gly 
            340                 345                 350         


Lys Ala Glu Ile Leu Lys Tyr Ile Leu Ser Arg Glu Ile Lys Glu Lys 
        355                 360                 365             


Arg Leu Arg Ser Leu Ser Arg Lys Phe Thr Asp Trp Ala Tyr Gly Pro 
    370                 375                 380                 


Val Ser Ser Ser Leu Tyr Asp Leu Thr Asn Val Asp Thr Thr Thr Asp 
385                 390                 395                 400 


Asn Ser Val Leu Glu Ile Thr Val Tyr Asn Thr Asn Ile Asp Asn Arg 
                405                 410                 415     


His Glu Met Leu Thr Leu Glu Pro Leu His Thr Leu Leu His Met Lys 
            420                 425                 430         


Trp Lys Lys Phe Ala Lys His Met Phe Phe Leu Ser Phe Cys Phe Tyr 
        435                 440                 445             


Phe Phe Tyr Asn Ile Thr Leu Thr Leu Val Ser Tyr Tyr Arg Pro Arg 
    450                 455                 460                 


Glu Glu Glu Ala Ile Pro His Pro Leu Ala Leu Thr His Lys Met Gly 
465                 470                 475                 480 


Trp Leu Gln Leu Leu Gly Arg Met Phe Val Leu Ile Trp Ala Met Cys 
                485                 490                 495     


Ile Ser Val Lys Glu Gly Ile Ala Ile Phe Leu Leu Arg Pro Ser Asp 
            500                 505                 510         


Leu Gln Ser Ile Leu Ser Asp Ala Trp Phe His Phe Val Phe Phe Ile 
        515                 520                 525             


Gln Ala Val Leu Val Ile Leu Ser Val Phe Leu Tyr Leu Phe Ala Tyr 
    530                 535                 540                 


Lys Glu Tyr Leu Ala Cys Leu Val Leu Ala Met Ala Leu Gly Trp Ala 
545                 550                 555                 560 


Asn Met Leu Tyr Tyr Thr Arg Gly Phe Gln Ser Met Gly Met Tyr Ser 
                565                 570                 575     


Val Met Ile Gln Lys Val Ile Leu His Asp Val Leu Lys Phe Leu Phe 
            580                 585                 590         


Val Tyr Ile Val Phe Leu Leu Gly Phe Gly Val Ala Leu Ala Ser Leu 
        595                 600                 605             


Ile Glu Lys Cys Pro Lys Asp Asn Lys Asp Cys Ser Ser Tyr Gly Ser 
    610                 615                 620                 


Phe Ser Asp Ala Val Leu Glu Leu Phe Lys Leu Thr Ile Gly Leu Gly 
625                 630                 635                 640 


Asp Leu Asn Ile Gln Gln Asn Ser Lys Tyr Pro Ile Leu Phe Leu Phe 
                645                 650                 655     


Leu Leu Ile Thr Tyr Val Ile Leu Thr Phe Val Leu Leu Leu Asn Met 
            660                 665                 670         


Leu Ile Ala Leu Met Gly Glu Thr Val Glu Asn Val Ser Lys Glu Ser 
        675                 680                 685             


Glu Arg Ile Trp Arg Leu Gln Arg Ala Arg Thr Ile Leu Glu Phe Glu 
    690                 695                 700                 


Lys Met Leu Pro Glu Trp Leu Arg Ser Arg Phe Arg Met Gly Glu Leu 
705                 710                 715                 720 


Cys Lys Val Ala Glu Asp Asp Phe Arg Leu Cys Leu Arg Ile Asn Glu 
                725                 730                 735     


Val Lys Trp Thr Glu Trp Lys Thr His Val Ser Phe Leu Asn Glu Asp 
            740                 745                 750         


Pro Gly Pro Val Arg Arg Thr Asp Phe Asn Lys Ile Gln Asp Ser Ser 
        755                 760                 765             


Arg Asn Asn Ser Lys Thr Thr Leu Asn Ala Phe Glu Glu Val Glu Glu 
    770                 775                 780                 


Phe Pro Glu Thr Ser Val 
785                 790 


<210>  5926
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  5926

Met Ala Ala Pro Arg Ala Gly Arg Gly Ala Gly Trp Ser Leu Arg Ala 
1               5                   10                  15      


Trp Arg Ala Leu Gly Gly Ile Arg Trp Gly Arg Arg Pro Arg Leu Thr 
            20                  25                  30          


Pro Asp Leu Arg Ala Leu Leu Thr Ser Gly Thr Ser Asp Pro Arg Ala 
        35                  40                  45              


Arg Val Thr Tyr Gly Thr Pro Ser Leu Trp Ala Arg Leu Ser Val Gly 
    50                  55                  60                  


Val Thr Glu Pro Arg Ala Cys Leu Thr Ser Gly Thr Pro Gly Pro Arg 
65                  70                  75                  80  


Ala Gln Leu Thr Ala Val Thr Pro Asp Thr Arg Thr Arg Glu Ala Ser 
                85                  90                  95      


Glu Asn Ser Gly Thr Arg Ser Arg Ala Trp Leu Ala Val Ala Leu Gly 
            100                 105                 110         


Ala Gly Gly Ala Val Leu Leu Leu Leu Trp Gly Gly Gly Arg Gly Pro 
        115                 120                 125             


Pro Ala Val Leu Ala Ala Val Pro Ser Pro Pro Pro Ala Ser Pro Arg 
    130                 135                 140                 


Ser Gln Tyr Asn Phe Ile Ala Asp Val Val Glu Lys Thr Ala Pro Ala 
145                 150                 155                 160 


Val Val Tyr Ile Glu Ile Leu Asp Arg His Pro Phe Leu Gly Arg Glu 
                165                 170                 175     


Val Pro Ile Ser Asn Gly Ser Gly Phe Val Val Ala Ala Asp Gly Leu 
            180                 185                 190         


Ile Val Thr Asn Ala His Val Val Ala Asp Arg Arg Arg Val Arg Val 
        195                 200                 205             


Arg Leu Leu Ser Gly Asp Thr Tyr Glu Ala Val Val Thr Ala Val Asp 
    210                 215                 220                 


Pro Val Ala Asp Ile Ala Thr Leu Arg Ile Gln Thr Lys Phe Gly Asn 
225                 230                 235                 240 


Ser Gly Gly Pro Leu Val Asn Leu Asp Gly Glu Val Ile Gly Val Asn 
                245                 250                 255     


Thr Met Lys Val Thr Ala Gly Ile Ser Phe Ala Ile Pro Ser Asp Arg 
            260                 265                 270         


Leu Arg Glu Phe Leu His Arg Gly Glu Lys Lys Asn Ser Ser Ser Gly 
        275                 280                 285             


Ile Ser Gly Ser Gln Arg Arg Tyr Ile Gly Val Met Met Leu Thr Leu 
    290                 295                 300                 


Ser Pro Arg Ala Gly Leu Arg Pro Gly Asp Val Ile Leu Ala Ile Gly 
305                 310                 315                 320 


Glu Gln Met Val Gln Asn Ala Glu Asp Val Tyr Glu Ala Val Arg Thr 
                325                 330                 335     


Gln Ser Gln Leu Ala Val Gln Ile Arg Arg Gly Arg Glu Thr Leu Thr 
            340                 345                 350         


Leu Tyr Val Thr Pro Glu Val Thr Glu 
        355                 360     


<210>  5927
<211>  573
<212>  PRT
<213>  Homo sapiens

<400>  5927

Met Thr Pro Glu Ser Arg Asp Thr Thr Asp Leu Ser Pro Gly Gly Thr 
1               5                   10                  15      


Gln Glu Met Glu Gly Ile Val Ile Val Lys Val Glu Glu Glu Asp Glu 
            20                  25                  30          


Glu Asp His Phe Gln Lys Glu Arg Asn Lys Val Glu Ser Ser Pro Gln 
        35                  40                  45              


Val Leu Ser Arg Ser Thr Thr Met Asn Glu Arg Ala Leu Leu Ser Ser 
    50                  55                  60                  


Tyr Leu Val Ala Tyr Arg Val Ala Lys Glu Lys Met Ala His Thr Ala 
65                  70                  75                  80  


Ala Glu Lys Ile Ile Leu Pro Ala Cys Met Asp Met Val Arg Thr Ile 
                85                  90                  95      


Phe Asp Asp Lys Ser Ala Asp Lys Leu Arg Thr Ile Pro Leu Ser Asp 
            100                 105                 110         


Asn Thr Ile Ser Arg Arg Ile Cys Thr Ile Ala Lys His Leu Glu Ala 
        115                 120                 125             


Met Leu Ile Thr Arg Leu Gln Ser Gly Ile Asp Phe Ala Ile Gln Leu 
    130                 135                 140                 


Asp Glu Ser Thr Asp Ile Ala Ser Cys Pro Thr Leu Leu Val Tyr Val 
145                 150                 155                 160 


Arg Tyr Val Trp Gln Asp Asp Phe Val Glu Asp Leu Leu Cys Cys Leu 
                165                 170                 175     


Asn Leu Asn Ser His Ile Thr Gly Leu Asp Leu Phe Thr Glu Leu Glu 
            180                 185                 190         


Asn Cys Leu Leu Gly Gln Tyr Lys Leu Asn Trp Lys His Cys Lys Gly 
        195                 200                 205             


Ile Ser Ser Asp Gly Thr Ala Asn Met Thr Gly Lys His Ser Arg Leu 
    210                 215                 220                 


Thr Glu Lys Leu Leu Glu Ala Thr His Asn Asn Ala Val Trp Asn His 
225                 230                 235                 240 


Cys Phe Ile His Arg Glu Ala Leu Val Ser Lys Glu Ile Ser Pro Ser 
                245                 250                 255     


Leu Met Asp Val Leu Lys Asn Ala Val Lys Thr Val Asn Phe Ile Lys 
            260                 265                 270         


Gly Ser Ser Leu Asn Ser Arg Leu Leu Glu Ile Phe Cys Ser Glu Ile 
        275                 280                 285             


Gly Val Asn His Thr His Leu Leu Phe His Thr Glu Val Arg Trp Leu 
    290                 295                 300                 


Ser Gln Gly Lys Val Leu Ser Arg Val Tyr Glu Leu Arg Asn Glu Ile 
305                 310                 315                 320 


Tyr Ile Phe Leu Val Glu Lys Gln Ser His Leu Ala Asn Ile Phe Glu 
                325                 330                 335     


Asp Asp Ile Trp Val Thr Lys Leu Ala Tyr Leu Ser Asp Ile Phe Gly 
            340                 345                 350         


Ile Leu Asn Glu Leu Ser Leu Lys Met Gln Gly Lys Asn Asn Asp Ile 
        355                 360                 365             


Phe Gln Tyr Leu Glu His Ile Leu Gly Phe Gln Lys Thr Leu Leu Leu 
    370                 375                 380                 


Trp Gln Ala Arg Leu Lys Ser Asn Arg Pro Ser Tyr Tyr Met Phe Pro 
385                 390                 395                 400 


Thr Leu Leu Gln His Ile Glu Glu Asn Ile Ile Asn Glu Asp Cys Leu 
                405                 410                 415     


Lys Glu Ile Lys Leu Glu Ile Leu Leu His Leu Thr Ser Leu Ser Gln 
            420                 425                 430         


Thr Phe Asn Tyr Tyr Phe Pro Glu Glu Lys Phe Glu Ser Leu Lys Glu 
        435                 440                 445             


Asn Ile Trp Met Lys Asp Pro Phe Ala Phe Gln Asn Pro Glu Ser Ile 
    450                 455                 460                 


Ile Glu Leu Asn Leu Glu Pro Glu Glu Glu Asn Glu Leu Leu Gln Leu 
465                 470                 475                 480 


Ser Ser Ser Phe Thr Leu Lys Asn Tyr Tyr Lys Ile Leu Ser Leu Ser 
                485                 490                 495     


Ala Phe Trp Ile Lys Ile Lys Asp Asp Phe Pro Leu Leu Ser Arg Lys 
            500                 505                 510         


Ser Ile Leu Leu Leu Leu Pro Phe Thr Thr Thr Tyr Leu Cys Glu Leu 
        515                 520                 525             


Gly Phe Ser Ile Leu Thr Arg Leu Lys Thr Lys Lys Arg Asn Arg Leu 
    530                 535                 540                 


Asn Ser Ala Pro Asp Met Arg Val Ala Leu Ser Ser Cys Val Pro Asp 
545                 550                 555                 560 


Trp Lys Glu Leu Met Asn Arg Gln Ala His Pro Ser His 
                565                 570             


<210>  5928
<211>  1200
<212>  PRT
<213>  Homo sapiens

<400>  5928

Met Arg Ala Gln Gly Arg Gly Arg Leu Pro Arg Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Leu Trp Val Gln Ala Ala Arg Pro Met Gly Tyr Phe Glu Leu 
            20                  25                  30          


Gln Leu Ser Ala Leu Arg Asn Val Asn Gly Glu Leu Leu Ser Gly Ala 
        35                  40                  45              


Cys Cys Asp Gly Asp Gly Arg Thr Thr Arg Ala Gly Gly Cys Gly His 
    50                  55                  60                  


Asp Glu Cys Asp Thr Tyr Val Arg Val Cys Leu Lys Glu Tyr Gln Ala 
65                  70                  75                  80  


Lys Val Thr Pro Thr Gly Pro Cys Ser Tyr Gly His Gly Ala Thr Pro 
                85                  90                  95      


Val Leu Gly Gly Asn Ser Phe Tyr Leu Pro Pro Ala Gly Ala Ala Gly 
            100                 105                 110         


Asp Arg Ala Arg Ala Arg Ala Arg Ala Gly Gly Asp Gln Asp Pro Gly 
        115                 120                 125             


Leu Val Val Ile Pro Phe Gln Phe Ala Trp Pro Arg Ser Phe Thr Leu 
    130                 135                 140                 


Ile Val Glu Ala Trp Asp Trp Asp Asn Asp Thr Thr Pro Asn Glu Glu 
145                 150                 155                 160 


Leu Leu Ile Glu Arg Val Ser His Ala Gly Met Ile Asn Pro Glu Asp 
                165                 170                 175     


Arg Trp Lys Ser Leu His Phe Ser Gly His Val Ala His Leu Glu Leu 
            180                 185                 190         


Gln Ile Arg Val Arg Cys Asp Glu Asn Tyr Tyr Ser Ala Thr Cys Asn 
        195                 200                 205             


Lys Phe Cys Arg Pro Arg Asn Asp Phe Phe Gly His Tyr Thr Cys Asp 
    210                 215                 220                 


Gln Tyr Gly Asn Lys Ala Cys Met Asp Gly Trp Met Gly Lys Glu Cys 
225                 230                 235                 240 


Lys Glu Ala Val Cys Lys Gln Gly Cys Asn Leu Leu His Gly Gly Cys 
                245                 250                 255     


Thr Val Pro Gly Glu Cys Arg Cys Ser Tyr Gly Trp Gln Gly Arg Phe 
            260                 265                 270         


Cys Asp Glu Cys Val Pro Tyr Pro Gly Cys Val His Gly Ser Cys Val 
        275                 280                 285             


Glu Pro Trp Gln Cys Asn Cys Glu Thr Asn Trp Gly Gly Leu Leu Cys 
    290                 295                 300                 


Asp Lys Asp Leu Asn Tyr Cys Gly Ser His His Pro Cys Thr Asn Gly 
305                 310                 315                 320 


Gly Thr Cys Ile Asn Ala Glu Pro Asp Gln Tyr Arg Cys Thr Cys Pro 
                325                 330                 335     


Asp Gly Tyr Ser Gly Arg Asn Cys Glu Lys Ala Glu His Ala Cys Thr 
            340                 345                 350         


Ser Asn Pro Cys Ala Asn Gly Gly Ser Cys His Glu Val Pro Ser Gly 
        355                 360                 365             


Phe Glu Cys His Cys Pro Ser Gly Trp Ser Gly Pro Thr Cys Ala Leu 
    370                 375                 380                 


Asp Ile Asp Glu Cys Ala Ser Asn Pro Cys Ala Ala Gly Gly Thr Cys 
385                 390                 395                 400 


Val Asp Gln Val Asp Gly Phe Glu Cys Ile Cys Pro Glu Gln Trp Val 
                405                 410                 415     


Gly Ala Thr Cys Gln Leu Asp Val Asn Asp Cys Arg Gly Gln Cys Gln 
            420                 425                 430         


His Gly Gly Thr Cys Lys Asp Leu Val Asn Gly Tyr Gln Cys Val Cys 
        435                 440                 445             


Pro Arg Gly Phe Gly Gly Arg His Cys Glu Leu Glu Arg Asp Glu Cys 
    450                 455                 460                 


Ala Ser Ser Pro Cys His Ser Gly Gly Leu Cys Glu Asp Leu Ala Asp 
465                 470                 475                 480 


Gly Phe His Cys His Cys Pro Gln Gly Phe Ser Gly Pro Leu Cys Glu 
                485                 490                 495     


Val Asp Val Asp Leu Cys Glu Pro Ser Pro Cys Arg Asn Gly Ala Arg 
            500                 505                 510         


Cys Tyr Asn Leu Glu Gly Asp Tyr Tyr Cys Ala Cys Pro Asp Asp Phe 
        515                 520                 525             


Gly Gly Lys Asn Cys Ser Val Pro Arg Glu Pro Cys Pro Gly Gly Ala 
    530                 535                 540                 


Cys Arg Val Ile Asp Gly Cys Gly Ser Asp Ala Gly Pro Gly Met Pro 
545                 550                 555                 560 


Gly Thr Ala Ala Ser Gly Val Cys Gly Pro His Gly Arg Cys Val Ser 
                565                 570                 575     


Gln Pro Gly Gly Asn Phe Ser Cys Ile Cys Asp Ser Gly Phe Thr Gly 
            580                 585                 590         


Thr Tyr Cys His Glu Asn Ile Asp Asp Cys Leu Gly Gln Pro Cys Arg 
        595                 600                 605             


Asn Gly Gly Thr Cys Ile Asp Glu Val Asp Ala Phe Arg Cys Phe Cys 
    610                 615                 620                 


Pro Ser Gly Trp Glu Gly Glu Leu Cys Asp Thr Asn Pro Asn Asp Cys 
625                 630                 635                 640 


Leu Pro Asp Pro Cys His Ser Arg Gly Arg Cys Tyr Asp Leu Val Asn 
                645                 650                 655     


Asp Phe Tyr Cys Ala Cys Asp Asp Gly Trp Lys Gly Lys Thr Cys His 
            660                 665                 670         


Ser Arg Glu Phe Gln Cys Asp Ala Tyr Thr Cys Ser Asn Gly Gly Thr 
        675                 680                 685             


Cys Tyr Asp Ser Gly Asp Thr Phe Arg Cys Ala Cys Pro Pro Gly Trp 
    690                 695                 700                 


Lys Gly Ser Thr Cys Ala Val Ala Lys Asn Ser Ser Cys Leu Pro Asn 
705                 710                 715                 720 


Pro Cys Val Asn Gly Gly Thr Cys Val Gly Ser Gly Ala Ser Phe Ser 
                725                 730                 735     


Cys Ile Cys Arg Asp Gly Trp Glu Gly Arg Thr Cys Thr His Asn Thr 
            740                 745                 750         


Asn Asp Cys Asn Pro Leu Pro Cys Tyr Asn Gly Gly Ile Cys Val Asp 
        755                 760                 765             


Gly Val Asn Trp Phe Arg Cys Glu Cys Ala Pro Gly Phe Ala Gly Pro 
    770                 775                 780                 


Asp Cys Arg Ile Asn Ile Asp Glu Cys Gln Ser Ser Pro Cys Ala Tyr 
785                 790                 795                 800 


Gly Ala Thr Cys Val Asp Glu Ile Asn Gly Tyr Arg Cys Ser Cys Pro 
                805                 810                 815     


Pro Gly Arg Ala Gly Pro Arg Cys Gln Glu Val Ile Gly Phe Gly Arg 
            820                 825                 830         


Ser Cys Trp Ser Arg Gly Thr Pro Phe Pro His Gly Ser Ser Trp Val 
        835                 840                 845             


Glu Asp Cys Asn Ser Cys Arg Cys Leu Asp Gly Arg Arg Asp Cys Ser 
    850                 855                 860                 


Lys Val Trp Cys Gly Trp Lys Pro Cys Leu Leu Ala Gly Gln Pro Glu 
865                 870                 875                 880 


Ala Leu Ser Ala Gln Cys Pro Leu Gly Gln Arg Cys Leu Glu Lys Ala 
                885                 890                 895     


Pro Gly Gln Cys Leu Arg Pro Pro Cys Glu Ala Trp Gly Glu Cys Gly 
            900                 905                 910         


Ala Glu Glu Pro Pro Ser Thr Pro Cys Leu Pro Arg Ser Gly His Leu 
        915                 920                 925             


Asp Asn Asn Cys Ala Arg Leu Thr Leu His Phe Asn Arg Asp His Val 
    930                 935                 940                 


Pro Gln Gly Thr Thr Val Gly Ala Ile Cys Ser Gly Ile Arg Ser Leu 
945                 950                 955                 960 


Pro Ala Thr Arg Ala Val Ala Arg Asp Arg Leu Leu Val Leu Leu Cys 
                965                 970                 975     


Asp Arg Ala Ser Ser Gly Ala Ser Ala Val Glu Val Ala Val Ser Phe 
            980                 985                 990         


Ser Pro Ala Arg Asp Leu Pro Asp  Ser Ser Leu Ile Gln  Gly Ala Ala 
        995                 1000                 1005             


His Ala  Ile Val Ala Ala Ile  Thr Gln Arg Gly Asn  Ser Ser Leu 
    1010                 1015                 1020             


Leu Leu  Ala Val Thr Glu Val  Lys Val Glu Thr Val  Val Thr Gly 
    1025                 1030                 1035             


Gly Ser  Ser Thr Gly Leu Leu  Val Pro Val Leu Cys  Gly Ala Phe 
    1040                 1045                 1050             


Ser Val  Leu Trp Leu Ala Cys  Val Val Leu Cys Val  Trp Trp Thr 
    1055                 1060                 1065             


Arg Lys  Arg Arg Lys Glu Arg  Glu Arg Ser Arg Leu  Pro Arg Glu 
    1070                 1075                 1080             


Glu Ser  Ala Asn Asn Gln Trp  Ala Pro Leu Asn Pro  Ile Arg Asn 
    1085                 1090                 1095             


Pro Ile  Glu Arg Pro Gly Gly  His Lys Asp Val Leu  Tyr Gln Cys 
    1100                 1105                 1110             


Lys Asn  Phe Thr Pro Pro Pro  Arg Arg Ala Asp Glu  Ala Leu Pro 
    1115                 1120                 1125             


Gly Pro  Ala Gly His Ala Ala  Val Arg Glu Asp Glu  Glu Asp Glu 
    1130                 1135                 1140             


Asp Leu  Gly Arg Gly Glu Glu  Asp Ser Leu Glu Ala  Glu Lys Phe 
    1145                 1150                 1155             


Leu Ser  His Lys Phe Thr Lys  Asp Pro Gly Arg Ser  Pro Gly Arg 
    1160                 1165                 1170             


Pro Ala  His Trp Ala Ser Gly  Pro Lys Val Asp Asn  Arg Ala Val 
    1175                 1180                 1185             


Arg Ser  Ile Asn Glu Ala Arg  Tyr Ala Gly Lys Glu  
    1190                 1195                 1200 


<210>  5929
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  5929

Met Gly Ser Thr Lys His Trp Gly Glu Trp Leu Leu Asn Leu Lys Val 
1               5                   10                  15      


Ala Pro Ala Gly Val Phe Gly Val Ala Phe Leu Ala Arg Val Ala Leu 
            20                  25                  30          


Val Phe Tyr Gly Val Phe Gln Asp Arg Thr Leu His Val Arg Tyr Thr 
        35                  40                  45              


Asp Ile Asp Tyr Gln Val Phe Thr Asp Ala Ala Arg Phe Val Thr Glu 
    50                  55                  60                  


Gly Arg Ser Pro Tyr Leu Arg Ala Thr Tyr Arg Tyr Thr Pro Leu Leu 
65                  70                  75                  80  


Gly Trp Leu Leu Thr Pro Asn Ile Tyr Leu Ser Glu Leu Phe Gly Lys 
                85                  90                  95      


Phe Leu Phe Ile Ser Cys Asp Leu Leu Thr Ala Phe Leu Leu Tyr Arg 
            100                 105                 110         


Leu Leu Leu Leu Lys Gly Leu Gly Arg Arg Gln Ala Cys Gly Tyr Cys 
        115                 120                 125             


Val Phe Trp Leu Leu Asn Pro Leu Pro Met Ala Val Ser Ser Arg Gly 
    130                 135                 140                 


Asn Ala Asp Ser Ile Val Ala Ser Leu Val Leu Met Val Leu Tyr Leu 
145                 150                 155                 160 


Ile Lys Lys Arg Leu Val Ala Cys Ala Ala Val Phe Tyr Gly Phe Ala 
                165                 170                 175     


Val His Met Lys Ile Tyr Pro Val Thr Tyr Ile Leu Pro Ile Thr Leu 
            180                 185                 190         


His Leu Leu Pro Asp Arg Asp Asn Asp Lys Ser Leu Arg Gln Phe Arg 
        195                 200                 205             


Tyr Thr Phe Gln Ala Cys Leu Tyr Glu Leu Leu Lys Arg Leu Cys Asn 
    210                 215                 220                 


Arg Ala Val Leu Leu Phe Val Ala Val Ala Gly Leu Thr Phe Phe Ala 
225                 230                 235                 240 


Leu Ser Phe Gly Phe Tyr Tyr Glu Tyr Gly Trp Glu Phe Leu Glu His 
                245                 250                 255     


Thr Tyr Phe Tyr His Leu Thr Arg Arg Asp Ile Arg His Asn Phe Ser 
            260                 265                 270         


Pro Tyr Phe Tyr Met Leu Tyr Leu Thr Ala Glu Ser Lys Trp Ser Phe 
        275                 280                 285             


Ser Leu Gly Ile Ala Ala Phe Leu Pro Gln Leu Ile Leu Leu Ser Ala 
    290                 295                 300                 


Val Ser Phe Ala Tyr Tyr Arg Asp Leu Val Phe Cys Cys Phe Leu His 
305                 310                 315                 320 


Thr Ser Ile Phe Val Thr Phe Asn Lys Val Cys Thr Ser Gln Tyr Phe 
                325                 330                 335     


Leu Trp Tyr Leu Cys Leu Leu Pro Leu Val Met Pro Leu Val Arg Met 
            340                 345                 350         


Pro Trp Lys Arg Ala Val Val Leu Leu Met Leu Trp Phe Ile Gly Gln 
        355                 360                 365             


Ala Met Trp Leu Ala Pro Ala Tyr Val Leu Glu Phe Gln Gly Lys Asn 
    370                 375                 380                 


Thr Phe Leu Phe Ile Trp Leu Ala Gly Leu Phe Phe Leu Leu Ile Asn 
385                 390                 395                 400 


Cys Ser Ile Leu Ile Gln Ile Ile Ser His Tyr Lys Glu Glu Pro Leu 
                405                 410                 415     


Thr Glu Arg Ile Lys Tyr Asp 
            420             


<210>  5930
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  5930

Met Asp Pro Lys Arg Ser Gln Lys Glu Ser Val Leu Ile Thr Gly Gly 
1               5                   10                  15      


Ser Gly Tyr Phe Gly Phe Arg Leu Gly Cys Ala Leu Asn Gln Asn Gly 
            20                  25                  30          


Val His Val Ile Leu Phe Asp Ile Ser Ser Pro Ala Gln Thr Ile Pro 
        35                  40                  45              


Glu Gly Ile Lys Phe Ile Gln Gly Asp Ile Arg His Leu Ser Asp Val 
    50                  55                  60                  


Glu Lys Ala Phe Gln Asp Ala Asp Val Thr Cys Val Phe His Ile Ala 
65                  70                  75                  80  


Ser Tyr Gly Met Ser Gly Arg Glu Gln Leu Asn Arg Asn Leu Ile Lys 
                85                  90                  95      


Glu Val Asn Val Arg Gly Thr Asp Asn Ile Leu Gln Val Cys Gln Arg 
            100                 105                 110         


Arg Arg Val Pro Arg Leu Val Tyr Thr Ser Thr Phe Asn Val Ile Phe 
        115                 120                 125             


Gly Gly Gln Val Ile Arg Asn Gly Asp Glu Ser Leu Pro Tyr Leu Pro 
    130                 135                 140                 


Leu His Leu His Pro Asp His Tyr Ser Arg Thr Lys Ser Ile Ala Glu 
145                 150                 155                 160 


Gln Lys Val Leu Glu Ala Asn Ala Thr Pro Leu Asp Arg Gly Asp Gly 
                165                 170                 175     


Val Leu Arg Thr Cys Ala Leu Arg Pro Ala Gly Ile Tyr Gly Pro Gly 
            180                 185                 190         


Glu Gln Arg His Leu Pro Arg Ile Val Ser Tyr Ile Glu Lys Gly Leu 
        195                 200                 205             


Phe Lys Phe Val Tyr Gly Asp Pro Arg Ser Leu Val Glu Phe Val His 
    210                 215                 220                 


Val Asp Asn Leu Val Gln Ala His Ile Leu Ala Ser Glu Ala Leu Arg 
225                 230                 235                 240 


Ala Asp Lys Gly His Ile Ala Ser Gly Gln Pro Tyr Phe Ile Ser Asp 
                245                 250                 255     


Gly Arg Pro Val Asn Asn Phe Glu Phe Phe Arg Pro Leu Val Glu Gly 
            260                 265                 270         


Leu Gly Tyr Thr Phe Pro Ser Thr Arg Leu Pro Leu Thr Leu Val Tyr 
        275                 280                 285             


Cys Phe Ala Phe Leu Thr Glu Met Val His Phe Ile Leu Gly Arg Leu 
    290                 295                 300                 


Tyr Asn Phe Gln Pro Phe Leu Thr Arg Thr Glu Val Tyr Lys Thr Gly 
305                 310                 315                 320 


Val Thr His Tyr Phe Ser Leu Glu Lys Ala Lys Lys Glu Leu Gly Tyr 
                325                 330                 335     


Lys Ala Gln Pro Phe Asp Leu Gln Glu Ala Val Glu Trp Phe Lys Ala 
            340                 345                 350         


His Gly His Gly Arg Ser Ser Gly Ser Arg Asp Ser Glu Cys Phe Val 
        355                 360                 365             


Trp Asp Gly Leu Leu Val Phe Leu Leu Ile Ile Ala Val Leu Met Trp 
    370                 375                 380                 


Leu Pro Ser Ser Val Ile Leu Ser Leu 
385                 390             


<210>  5931
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  5931

Met Glu Lys Leu Arg Arg Val Leu Ser Gly Gln Asp Asp Glu Glu Gln 
1               5                   10                  15      


Gly Leu Thr Ala Gln Val Leu Asp Ala Ser Ser Leu Ser Phe Asn Thr 
            20                  25                  30          


Arg Leu Lys Trp Phe Ala Ile Cys Phe Val Cys Gly Val Phe Phe Ser 
        35                  40                  45              


Ile Leu Gly Thr Gly Leu Leu Trp Leu Pro Gly Gly Ile Lys Leu Phe 
    50                  55                  60                  


Ala Val Phe Tyr Thr Leu Gly Asn Leu Ala Ala Leu Ala Ser Thr Cys 
65                  70                  75                  80  


Phe Leu Met Gly Pro Val Lys Gln Leu Lys Lys Met Phe Glu Ala Thr 
                85                  90                  95      


Arg Leu Leu Ala Thr Ile Val Met Leu Leu Cys Phe Ile Phe Thr Leu 
            100                 105                 110         


Cys Ala Ala Leu Trp Trp His Lys Lys Gly Leu Ala Val Leu Phe Cys 
        115                 120                 125             


Ile Leu Gln Phe Leu Ser Met Thr Trp Tyr Ser Leu Ser Tyr Ile Pro 
    130                 135                 140                 


Tyr Ala Arg Asp Ala Val Ile Lys Cys Cys Ser Ser Leu Leu Ser 
145                 150                 155                 


<210>  5932
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  5932

Met Lys Leu Ala Phe Leu Phe Leu Gly Pro Met Ala Leu Leu Leu Leu 
1               5                   10                  15      


Ala Gly Tyr Gly Cys Val Leu Gly Ala Ser Ser Gly Asn Leu Arg Thr 
            20                  25                  30          


Phe Val Gly Cys Ala Val Arg Glu Phe Thr Phe Leu Ala Lys Lys Pro 
        35                  40                  45              


Gly Cys Arg Gly Leu Arg Ile Thr Thr Asp Ala Cys Trp Gly Arg Cys 
    50                  55                  60                  


Glu Thr Trp Glu Lys Pro Ile Leu Glu Pro Pro Tyr Ile Glu Ala His 
65                  70                  75                  80  


His Arg Val Cys Thr Tyr Asn Glu Thr Lys Gln Val Thr Val Lys Leu 
                85                  90                  95      


Pro Asn Cys Ala Pro Gly Val Asp Pro Phe Tyr Thr Tyr Pro Val Ala 
            100                 105                 110         


Ile Arg Cys Asp Cys Gly Ala Cys Ser Thr Ala Thr Thr Glu Cys Glu 
        115                 120                 125             


Thr Ile 
    130 


<210>  5933
<211>  617
<212>  PRT
<213>  Homo sapiens

<400>  5933

Met Val Pro Val Glu Asn Thr Glu Gly Pro Ser Leu Leu Asn Gln Lys 
1               5                   10                  15      


Gly Thr Ala Val Glu Thr Glu Gly Ser Gly Ser Arg His Pro Pro Trp 
            20                  25                  30          


Ala Arg Gly Cys Gly Met Phe Thr Phe Leu Ser Ser Val Thr Ala Ala 
        35                  40                  45              


Val Ser Gly Leu Leu Val Gly Tyr Glu Leu Gly Ile Ile Ser Gly Ala 
    50                  55                  60                  


Leu Leu Gln Ile Lys Thr Leu Leu Ala Leu Ser Cys His Glu Gln Glu 
65                  70                  75                  80  


Met Val Val Ser Ser Leu Val Ile Gly Ala Leu Leu Ala Ser Leu Thr 
                85                  90                  95      


Gly Gly Val Leu Ile Asp Arg Tyr Gly Arg Arg Thr Ala Ile Ile Leu 
            100                 105                 110         


Ser Ser Cys Leu Leu Gly Leu Gly Ser Leu Val Leu Ile Leu Ser Leu 
        115                 120                 125             


Ser Tyr Thr Val Leu Ile Val Gly Arg Ile Ala Ile Gly Val Ser Ile 
    130                 135                 140                 


Ser Leu Ser Ser Ile Ala Thr Cys Val Tyr Ile Ala Glu Ile Ala Pro 
145                 150                 155                 160 


Gln His Arg Arg Gly Leu Leu Val Ser Leu Asn Glu Leu Met Ile Val 
                165                 170                 175     


Ile Gly Ile Leu Ser Ala Tyr Ile Ser Asn Tyr Ala Phe Ala Asn Val 
            180                 185                 190         


Phe His Gly Trp Lys Tyr Met Phe Gly Leu Val Ile Pro Leu Gly Val 
        195                 200                 205             


Leu Gln Ala Ile Ala Met Tyr Phe Leu Pro Pro Ser Pro Arg Phe Leu 
    210                 215                 220                 


Val Met Lys Gly Gln Glu Gly Ala Ala Ser Lys Val Leu Gly Arg Leu 
225                 230                 235                 240 


Arg Ala Leu Ser Asp Thr Thr Glu Glu Leu Thr Val Ile Lys Ser Ser 
                245                 250                 255     


Leu Lys Asp Glu Tyr Gln Tyr Ser Phe Trp Asp Leu Phe Arg Ser Lys 
            260                 265                 270         


Asp Asn Met Arg Thr Arg Ile Met Ile Gly Leu Thr Leu Val Phe Phe 
        275                 280                 285             


Val Gln Ile Thr Gly Gln Pro Asn Ile Leu Phe Tyr Ala Ser Thr Val 
    290                 295                 300                 


Leu Lys Ser Val Gly Phe Gln Ser Asn Glu Ala Ala Ser Leu Ala Ser 
305                 310                 315                 320 


Thr Gly Val Gly Val Val Lys Val Ile Ser Thr Ile Pro Ala Thr Leu 
                325                 330                 335     


Leu Val Asp His Val Gly Ser Lys Thr Phe Leu Cys Ile Gly Ser Ser 
            340                 345                 350         


Val Met Ala Ala Ser Leu Val Thr Met Gly Ile Val Asn Leu Asn Ile 
        355                 360                 365             


His Met Asn Phe Thr His Ile Cys Arg Ser His Asn Ser Ile Asn Gln 
    370                 375                 380                 


Ser Leu Asp Glu Ser Val Ile Tyr Gly Pro Gly Asn Leu Ser Thr Asn 
385                 390                 395                 400 


Asn Asn Thr Leu Arg Asp His Phe Lys Gly Ile Ser Ser His Ser Arg 
                405                 410                 415     


Ser Ser Leu Met Pro Leu Arg Asn Asp Val Asp Lys Arg Gly Glu Thr 
            420                 425                 430         


Thr Ser Ala Ser Leu Leu Asn Ala Gly Leu Ser His Thr Glu Tyr Gln 
        435                 440                 445             


Ile Val Thr Asp Pro Gly Asp Val Pro Ala Phe Leu Lys Trp Leu Ser 
    450                 455                 460                 


Leu Ala Ser Leu Leu Val Tyr Val Ala Ala Phe Ser Ile Gly Leu Gly 
465                 470                 475                 480 


Pro Met Pro Trp Leu Val Leu Ser Glu Ile Phe Pro Gly Gly Ile Arg 
                485                 490                 495     


Gly Arg Ala Met Ala Leu Thr Ser Ser Met Asn Trp Gly Ile Asn Leu 
            500                 505                 510         


Leu Ile Ser Leu Thr Phe Leu Thr Val Thr Asp Leu Ile Gly Leu Pro 
        515                 520                 525             


Trp Val Cys Phe Ile Tyr Thr Ile Met Ser Leu Ala Ser Leu Leu Phe 
    530                 535                 540                 


Val Val Met Phe Ile Pro Glu Thr Lys Gly Cys Ser Leu Glu Gln Ile 
545                 550                 555                 560 


Ser Met Glu Leu Ala Lys Val Asn Tyr Val Lys Asn Asn Ile Cys Phe 
                565                 570                 575     


Met Ser His His Gln Glu Glu Leu Val Pro Lys Gln Pro Gln Lys Arg 
            580                 585                 590         


Lys Pro Gln Glu Gln Leu Leu Glu Cys Asn Lys Leu Cys Gly Arg Gly 
        595                 600                 605             


Gln Ser Arg Gln Leu Ser Pro Glu Thr 
    610                 615         


<210>  5934
<211>  1344
<212>  PRT
<213>  Homo sapiens

<400>  5934

Met Thr Arg Lys Arg Thr Tyr Trp Val Pro Asn Ser Ser Gly Gly Leu 
1               5                   10                  15      


Val Asn Arg Gly Ile Asp Ile Gly Asp Asp Met Val Ser Gly Leu Ile 
            20                  25                  30          


Tyr Lys Thr Tyr Thr Leu Gln Asp Gly Pro Trp Ser Gln Gln Glu Arg 
        35                  40                  45              


Asn Pro Glu Ala Pro Gly Arg Ala Ala Val Pro Pro Trp Gly Lys Tyr 
    50                  55                  60                  


Asp Ala Ala Leu Arg Thr Met Ile Pro Phe Arg Pro Lys Pro Arg Phe 
65                  70                  75                  80  


Pro Ala Pro Gln Pro Leu Asp Asn Ala Gly Leu Phe Ser Tyr Leu Thr 
                85                  90                  95      


Val Ser Trp Leu Thr Pro Leu Met Ile Gln Ser Leu Arg Ser Arg Leu 
            100                 105                 110         


Asp Glu Asn Thr Ile Pro Pro Leu Ser Val His Asp Ala Ser Asp Lys 
        115                 120                 125             


Asn Val Gln Arg Leu His Arg Leu Trp Glu Glu Glu Val Ser Arg Arg 
    130                 135                 140                 


Gly Ile Glu Lys Ala Ser Val Leu Leu Val Met Leu Arg Phe Gln Arg 
145                 150                 155                 160 


Thr Arg Leu Ile Phe Asp Ala Leu Leu Gly Ile Cys Phe Cys Ile Ala 
                165                 170                 175     


Ser Val Leu Gly Pro Ile Leu Ile Ile Pro Lys Ile Leu Glu Tyr Ser 
            180                 185                 190         


Glu Glu Gln Leu Gly Asn Val Val His Gly Val Gly Leu Cys Phe Ala 
        195                 200                 205             


Leu Phe Leu Ser Glu Cys Val Lys Ser Leu Ser Phe Ser Ser Ser Trp 
    210                 215                 220                 


Ile Ile Asn Gln Arg Thr Ala Ile Arg Phe Arg Ala Ala Val Ser Ser 
225                 230                 235                 240 


Phe Ala Phe Glu Lys Leu Ile Gln Phe Lys Ser Val Ile His Ile Thr 
                245                 250                 255     


Ser Gly Glu Ala Ile Ser Phe Phe Thr Gly Asp Val Asn Tyr Leu Phe 
            260                 265                 270         


Glu Gly Val Cys Tyr Gly Pro Leu Val Leu Ile Thr Cys Ala Ser Leu 
        275                 280                 285             


Val Ile Cys Ser Ile Ser Ser Tyr Phe Ile Ile Gly Tyr Thr Ala Phe 
    290                 295                 300                 


Ile Ala Ile Leu Cys Tyr Leu Leu Val Phe Pro Leu Ala Val Phe Met 
305                 310                 315                 320 


Thr Arg Met Ala Val Lys Ala Gln His His Thr Ser Glu Val Ser Asp 
                325                 330                 335     


Gln Arg Ile Arg Val Thr Ser Glu Val Leu Thr Cys Ile Lys Leu Ile 
            340                 345                 350         


Lys Met Tyr Thr Trp Glu Lys Pro Phe Ala Lys Ile Ile Glu Asp Leu 
        355                 360                 365             


Arg Arg Lys Glu Arg Lys Leu Leu Glu Lys Cys Gly Leu Val Gln Ser 
    370                 375                 380                 


Leu Thr Ser Ile Thr Leu Phe Ile Ile Pro Thr Val Ala Thr Ala Val 
385                 390                 395                 400 


Trp Val Leu Ile His Thr Ser Leu Lys Leu Lys Leu Thr Ala Ser Met 
                405                 410                 415     


Ala Phe Ser Met Leu Ala Ser Leu Asn Leu Leu Arg Leu Ser Val Phe 
            420                 425                 430         


Phe Val Pro Ile Ala Val Lys Gly Leu Thr Asn Ser Lys Ser Ala Val 
        435                 440                 445             


Met Arg Phe Lys Lys Phe Phe Leu Gln Glu Ser Pro Val Phe Tyr Val 
    450                 455                 460                 


Gln Thr Leu Gln Asp Pro Ser Lys Ala Leu Val Phe Glu Glu Ala Thr 
465                 470                 475                 480 


Leu Ser Trp Gln Gln Thr Cys Pro Gly Ile Val Asn Gly Ala Leu Glu 
                485                 490                 495     


Leu Glu Arg Asn Gly His Ala Ser Glu Gly Met Thr Arg Pro Arg Asp 
            500                 505                 510         


Ala Leu Gly Pro Glu Glu Glu Gly Asn Ser Leu Gly Pro Glu Leu His 
        515                 520                 525             


Lys Ile Asn Leu Val Val Ser Lys Gly Met Met Leu Gly Val Cys Gly 
    530                 535                 540                 


Asn Thr Gly Ser Gly Lys Ser Ser Leu Leu Ser Ala Ile Leu Glu Glu 
545                 550                 555                 560 


Met His Leu Leu Glu Gly Ser Val Gly Val Gln Gly Ser Leu Ala Tyr 
                565                 570                 575     


Val Pro Gln Gln Ala Trp Ile Val Ser Gly Asn Ile Arg Glu Asn Ile 
            580                 585                 590         


Leu Met Gly Gly Ala Tyr Asp Lys Ala Arg Tyr Leu Gln Val Leu His 
        595                 600                 605             


Cys Cys Ser Leu Asn Arg Asp Leu Glu Leu Leu Pro Phe Gly Asp Met 
    610                 615                 620                 


Thr Glu Ile Gly Glu Arg Gly Leu Asn Leu Ser Gly Gly Gln Lys Gln 
625                 630                 635                 640 


Arg Ile Ser Leu Ala Arg Ala Val Tyr Ser Asp Arg Gln Ile Tyr Leu 
                645                 650                 655     


Leu Asp Asp Pro Leu Ser Ala Val Asp Ala His Val Gly Lys His Ile 
            660                 665                 670         


Phe Glu Glu Cys Ile Lys Lys Thr Leu Arg Gly Lys Thr Val Val Leu 
        675                 680                 685             


Val Thr His Gln Leu Gln Tyr Leu Glu Phe Cys Gly Gln Ile Ile Leu 
    690                 695                 700                 


Leu Glu Asn Gly Lys Ile Cys Glu Asn Gly Thr His Ser Glu Leu Met 
705                 710                 715                 720 


Gln Lys Lys Gly Lys Tyr Ala Gln Leu Ile Gln Lys Met His Lys Glu 
                725                 730                 735     


Ala Thr Ser Asp Met Leu Gln Asp Thr Ala Lys Ile Ala Glu Lys Pro 
            740                 745                 750         


Lys Val Glu Ser Gln Ala Leu Ala Thr Ser Leu Glu Glu Ser Leu Asn 
        755                 760                 765             


Gly Asn Ala Val Pro Glu His Gln Leu Thr Gln Glu Glu Glu Met Glu 
    770                 775                 780                 


Glu Gly Ser Leu Ser Trp Arg Val Tyr His His Tyr Ile Gln Ala Ala 
785                 790                 795                 800 


Gly Gly Tyr Met Val Ser Cys Ile Ile Phe Phe Phe Val Val Leu Ile 
                805                 810                 815     


Val Phe Leu Thr Ile Phe Ser Phe Trp Trp Leu Ser Tyr Trp Leu Glu 
            820                 825                 830         


Gln Gly Ser Gly Thr Asn Ser Ser Arg Glu Ser Asn Gly Thr Met Ala 
        835                 840                 845             


Asp Leu Gly Asn Ile Ala Asp Asn Pro Gln Leu Ser Phe Tyr Gln Leu 
    850                 855                 860                 


Val Tyr Gly Leu Asn Ala Leu Leu Leu Ile Cys Val Gly Val Cys Ser 
865                 870                 875                 880 


Ser Gly Ile Phe Thr Lys Val Thr Arg Lys Ala Ser Thr Ala Leu His 
                885                 890                 895     


Asn Lys Leu Phe Asn Lys Val Phe Arg Cys Pro Met Ser Phe Phe Asp 
            900                 905                 910         


Thr Ile Pro Ile Gly Arg Leu Leu Asn Cys Phe Ala Gly Asp Leu Glu 
        915                 920                 925             


Gln Leu Asp Gln Leu Leu Pro Ile Phe Ser Glu Gln Phe Leu Val Leu 
    930                 935                 940                 


Ser Leu Met Val Ile Ala Val Leu Leu Ile Val Ser Val Leu Ser Pro 
945                 950                 955                 960 


Tyr Ile Leu Leu Met Gly Ala Ile Ile Met Val Ile Cys Phe Ile Tyr 
                965                 970                 975     


Tyr Met Met Phe Lys Lys Ala Ile Gly Val Phe Lys Arg Leu Glu Asn 
            980                 985                 990         


Tyr Ser Arg Ser Pro Leu Phe Ser  His Ile Leu Asn Ser  Leu Gln Gly 
        995                 1000                 1005             


Leu Ser  Ser Ile His Val Tyr  Gly Lys Thr Glu Asp  Phe Ile Ser 
    1010                 1015                 1020             


Gln Phe  Lys Arg Leu Thr Asp  Ala Gln Asn Asn Tyr  Leu Leu Leu 
    1025                 1030                 1035             


Phe Leu  Ser Ser Thr Arg Trp  Met Ala Leu Arg Leu  Glu Ile Met 
    1040                 1045                 1050             


Thr Asn  Leu Val Thr Leu Ala  Val Ala Leu Phe Val  Ala Phe Gly 
    1055                 1060                 1065             


Ile Ser  Ser Thr Pro Tyr Ser  Phe Lys Val Met Ala  Val Asn Ile 
    1070                 1075                 1080             


Val Leu  Gln Leu Ala Ser Ser  Phe Gln Ala Thr Ala  Arg Ile Gly 
    1085                 1090                 1095             


Leu Glu  Thr Glu Ala Gln Phe  Thr Ala Val Glu Arg  Ile Leu Gln 
    1100                 1105                 1110             


Tyr Met  Lys Met Cys Val Ser  Glu Ala Pro Leu His  Met Glu Gly 
    1115                 1120                 1125             


Thr Ser  Cys Pro Gln Gly Trp  Pro Gln His Gly Glu  Ile Ile Phe 
    1130                 1135                 1140             


Gln Asp  Tyr His Met Lys Tyr  Arg Asp Asn Thr Pro  Thr Val Leu 
    1145                 1150                 1155             


His Gly  Ile Asn Leu Thr Ile  Arg Gly His Glu Val  Val Gly Ile 
    1160                 1165                 1170             


Val Gly  Arg Thr Gly Ser Gly  Lys Ser Ser Leu Gly  Met Ala Leu 
    1175                 1180                 1185             


Phe Arg  Leu Val Glu Pro Met  Ala Gly Arg Ile Leu  Ile Asp Gly 
    1190                 1195                 1200             


Val Asp  Ile Cys Ser Ile Gly  Leu Glu Asp Leu Arg  Ser Lys Leu 
    1205                 1210                 1215             


Ser Val  Ile Pro Gln Asp Pro  Val Leu Leu Ser Gly  Thr Ile Arg 
    1220                 1225                 1230             


Phe Asn  Leu Asp Pro Phe Asp  Arg His Thr Asp Gln  Gln Ile Trp 
    1235                 1240                 1245             


Asp Ala  Leu Glu Arg Thr Phe  Leu Thr Lys Ala Ile  Ile Leu Ile 
    1250                 1255                 1260             


Asp Glu  Ala Thr Ala Ser Ile  Asp Met Glu Thr Asp  Thr Leu Ile 
    1265                 1270                 1275             


Gln Arg  Thr Ile Arg Glu Ala  Phe Gln Gly Cys Thr  Val Leu Val 
    1280                 1285                 1290             


Ile Ala  His Arg Val Thr Thr  Val Leu Asn Cys Asp  His Ile Leu 
    1295                 1300                 1305             


Val Met  Gly Asn Gly Lys Val  Val Glu Phe Asp Arg  Pro Glu Val 
    1310                 1315                 1320             


Leu Arg  Lys Lys Pro Gly Ser  Leu Phe Ala Ala Leu  Met Ala Thr 
    1325                 1330                 1335             


Ala Thr  Ser Ser Leu Arg 
    1340                 


<210>  5935
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  5935

Met Ser Ser Asp Phe Glu Gly Tyr Glu Gln Asp Phe Ala Val Leu Thr 
1               5                   10                  15      


Ala Glu Ile Thr Ser Lys Ile Ala Arg Val Pro Arg Leu Pro Pro Asp 
            20                  25                  30          


Glu Lys Lys Gln Met Val Ala Asn Val Glu Lys Gln Leu Glu Glu Ala 
        35                  40                  45              


Lys Glu Leu Leu Glu Gln Met Asp Leu Glu Val Arg Glu Ile Pro Pro 
    50                  55                  60                  


Gln Ser Arg Gly Met Tyr Ser Asn Arg Met Arg Ser Tyr Lys Gln Glu 
65                  70                  75                  80  


Met Gly Lys Leu Glu Thr Asp Phe Lys Arg Ser Arg Ile Ala Tyr Ser 
                85                  90                  95      


Asp Glu Val Arg Asn Glu Leu Leu Gly Asp Asp Gly Asn Ser Ser Glu 
            100                 105                 110         


Asn Gln Arg Ala His Leu Leu Asp Asn Thr Glu Arg Leu Glu Arg Ser 
        115                 120                 125             


Ser Arg Arg Leu Glu Ala Gly Tyr Gln Ile Ala Val Glu Thr Glu Gln 
    130                 135                 140                 


Ile Gly Gln Glu Met Leu Glu Asn Leu Ser His Asp Arg Glu Lys Ile 
145                 150                 155                 160 


Gln Arg Ala Arg Glu Arg Leu Arg Glu Thr Asp Ala Asn Leu Gly Lys 
                165                 170                 175     


Ser Ser Arg Ile Leu Thr Gly Met Leu Arg Arg Ile Ile Gln Asn Arg 
            180                 185                 190         


Ile Leu Leu Val Ile Leu Gly Ile Ile Val Val Ile Thr Ile Leu Met 
        195                 200                 205             


Ala Ile Thr Phe Ser Val Arg Arg His 
    210                 215         


<210>  5936
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  5936

Met Arg Val Arg Gly Pro Ala Arg Leu Ile Ala Ser Gly Ala Arg Leu 
1               5                   10                  15      


Leu Leu Arg Met Leu Ser Ala Leu Pro Gly Trp Gly Pro Ala His Leu 
            20                  25                  30          


Gln Arg Pro Leu Leu Gly Pro Ala Ser Cys Leu Gly Ile Leu Arg Pro 
        35                  40                  45              


Ala Met Thr Ala His Ser Phe Ala Leu Pro Val Ile Ile Phe Thr Thr 
    50                  55                  60                  


Phe Trp Gly Leu Val Gly Ile Ala Gly Pro Trp Phe Val Pro Lys Gly 
65                  70                  75                  80  


Pro Asn Arg Gly Val Ile Ile Thr Met Leu Val Ala Thr Ala Val Cys 
                85                  90                  95      


Cys Tyr Leu Phe Trp Leu Ile Ala Ile Leu Ala Gln Leu Asn Pro Leu 
            100                 105                 110         


Phe Gly Pro Gln Leu Lys Asn Glu Thr Ile Trp Tyr Val Arg Phe Leu 
        115                 120                 125             


Trp Glu 
    130 


<210>  5937
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  5937

Met Ala Ala Ser Ser Ser Glu Ile Ser Glu Met Lys Gly Val Glu Glu 
1               5                   10                  15      


Ser Pro Lys Val Pro Gly Glu Gly Pro Gly His Ser Glu Ala Glu Thr 
            20                  25                  30          


Gly Pro Pro Gln Val Leu Ala Gly Val Pro Asp Gln Pro Glu Ala Pro 
        35                  40                  45              


Gln Pro Gly Pro Asn Thr Thr Ala Ala Pro Val Asp Ser Gly Pro Lys 
    50                  55                  60                  


Ala Gly Leu Ala Pro Glu Thr Thr Glu Thr Pro Ala Gly Ala Ser Glu 
65                  70                  75                  80  


Thr Ala Gln Ala Thr Asp Leu Ser Leu Ser Pro Gly Gly Glu Ser Lys 
                85                  90                  95      


Ala Asn Cys Ser Pro Glu Asp Pro Cys Gln Glu Thr Val Ser Lys Pro 
            100                 105                 110         


Glu Val Ser Lys Glu Ala Thr Ala Asp Gln Gly Ser Arg Leu Glu Ser 
        115                 120                 125             


Ala Ala Pro Pro Glu Pro Ala Pro Glu Pro Ala Pro Gln Pro Asp Pro 
    130                 135                 140                 


Arg Pro Asp Ser Gln Pro Thr Pro Lys Pro Ala Leu Gln Pro Glu Leu 
145                 150                 155                 160 


Pro Thr Gln Glu Asp Pro Thr Pro Glu Ile Leu Ser Glu Ser Val Gly 
                165                 170                 175     


Glu Lys Gln Glu Asn Gly Ala Val Val Pro Leu Gln Ala Gly Asp Gly 
            180                 185                 190         


Glu Glu Gly Pro Ala Pro Glu Pro His Ser Pro Pro Ser Lys Lys Ser 
        195                 200                 205             


Pro Pro Ala Asn Gly Ala Pro Pro Arg Val Leu Gln Gln Leu Val Glu 
    210                 215                 220                 


Glu Asp Arg Met Arg Arg Ala His Ser Gly His Pro Gly Ser Pro Arg 
225                 230                 235                 240 


Gly Ser Leu Ser Arg His Pro Ser Ser Gln Leu Ala Gly Pro Gly Val 
                245                 250                 255     


Glu Gly Gly Glu Gly Thr Gln Lys Pro Arg Asp Tyr Ile Ile Leu Ala 
            260                 265                 270         


Ile Leu Ser Cys Phe Cys Pro Met Trp Pro Val Asn Ile Val Ala Phe 
        275                 280                 285             


Ala Tyr Ala Val Met Ser Arg Asn Ser Leu Gln Gln Gly Asp Val Asp 
    290                 295                 300                 


Gly Ala Gln Arg Leu Gly Arg Val Ala Lys Leu Leu Ser Ile Val Ala 
305                 310                 315                 320 


Leu Val Gly Gly Val Leu Ile Ile Ile Ala Ser Cys Val Ile Asn Leu 
                325                 330                 335     


Gly Val Tyr Lys 
            340 


<210>  5938
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  5938

Met Ser Phe Ile Cys Gly Leu Gln Ser Ala Ala Arg Asn His Val Phe 
1               5                   10                  15      


Phe Arg Phe Asn Ser Leu Ser Asn Trp Arg Lys Cys Asn Thr Leu Ala 
            20                  25                  30          


Ser Thr Ser Arg Gly Cys His Gln Val Gln Val Asn His Ile Val Asn 
        35                  40                  45              


Lys Tyr Gln Gly Leu Gly Val Asn Gln Cys Asp Arg Trp Ser Phe Leu 
    50                  55                  60                  


Pro Gly Asn Phe His Phe Tyr Ser Thr Phe Asn Asn Lys Arg Thr Gly 
65                  70                  75                  80  


Gly Leu Ser Ser Thr Lys Ser Lys Glu Ile Trp Arg Ile Thr Ser Lys 
                85                  90                  95      


Cys Thr Val Trp Asn Asp Ala Phe Ser Arg Gln Leu Leu Ile Lys Glu 
            100                 105                 110         


Val Thr Ala Val Pro Ser Leu Ser Val Leu His Pro Leu Ser Pro Ala 
        115                 120                 125             


Ser Ile Arg Ala Ile Arg Asn Phe His Thr Ser Pro Arg Phe Gln Ala 
    130                 135                 140                 


Ala Pro Val Pro Leu Leu Leu Met Ile Leu Lys Pro Val Gln Lys Leu 
145                 150                 155                 160 


Phe Ala Ile Ile Val Gly Arg Gly Ile Arg Lys Trp Trp Gln Ala Leu 
                165                 170                 175     


Pro Pro Asn Lys Lys Glu Val Val Lys Glu Asn Ile Arg Lys Asn Lys 
            180                 185                 190         


Trp Lys Leu Phe Leu Gly Leu Ser Ser Phe Gly Leu Leu Phe Val Val 
        195                 200                 205             


Phe Tyr Phe Thr His Leu Glu Val Ser Pro Ile Thr Gly Arg Ser Lys 
    210                 215                 220                 


Leu Leu Leu Leu Gly Lys Glu Gln Phe Arg Leu Leu Ser Glu Leu Glu 
225                 230                 235                 240 


Tyr Glu Ala Trp Met Glu Glu Phe Lys Asn Asp Met Leu Thr Glu Lys 
                245                 250                 255     


Asp Ala Arg Tyr Leu Ala Val Lys Glu Val Leu Cys His Leu Ile Glu 
            260                 265                 270         


Cys Asn Lys Asp Val Pro Gly Ile Ser Gln Ile Asn Trp Val Ile His 
        275                 280                 285             


Val Val Asp Ser Pro Ile Ile Asn Ala Phe Val Leu Pro Asn Gly Gln 
    290                 295                 300                 


Met Phe Val Phe Thr Gly Phe Leu Asn Ser Val Thr Asp Ile His Gln 
305                 310                 315                 320 


Leu Ser Phe Leu Leu Gly His Glu Ile Ala His Ala Val Leu Gly His 
                325                 330                 335     


Ala Ala Glu Lys Ala Gly Met Val His Leu Leu Asp Phe Leu Gly Met 
            340                 345                 350         


Ile Phe Leu Thr Met Ile Trp Ala Ile Cys Pro Arg Asp Ser Leu Ala 
        355                 360                 365             


Leu Leu Cys Gln Trp Ile Gln Ser Lys Leu Gln Glu Tyr Met Phe Asn 
    370                 375                 380                 


Arg Pro Tyr Ser Arg Lys Leu Glu Ala Glu Ala Asp Lys Ile Gly Leu 
385                 390                 395                 400 


Leu Leu Ala Ala Lys Ala Cys Ala Asp Ile Arg Ala Ser Ser Val Phe 
                405                 410                 415     


Trp Gln Gln Met Glu Phe Val Asp Ser Leu His Gly Gln Pro Lys Met 
            420                 425                 430         


Pro Glu Trp Leu Ser Thr His Pro Ser His Gly Asn Arg Val Glu Tyr 
        435                 440                 445             


Leu Asp Arg Leu Ile Pro Gln Ala Leu Lys Ile Arg Glu Met Cys Asn 
    450                 455                 460                 


Cys Pro Pro Leu Ser Asn Pro Asp Pro Arg Leu Leu Phe Lys Leu Ser 
465                 470                 475                 480 


Thr Lys His Phe Leu Glu Glu Ser Glu Lys Glu Asp Leu Asn Ile Thr 
                485                 490                 495     


Lys Lys Gln Lys Met Asp Thr Leu Pro Ile Gln Lys Gln Glu Gln Ile 
            500                 505                 510         


Pro Leu Thr Tyr Ile Val Glu Lys Arg Thr Gly Ser 
        515                 520                 


<210>  5939
<211>  794
<212>  PRT
<213>  Homo sapiens

<400>  5939

Met Ala Ser Pro Thr Leu Ser Pro Asp Ser Ser Ser Gln Glu Ala Leu 
1               5                   10                  15      


Ser Ala Pro Thr Cys Ser Pro Thr Ser Asp Ser Glu Asn Leu Ser Pro 
            20                  25                  30          


Asp Glu Leu Glu Leu Leu Ala Lys Leu Glu Glu Gln Asn Arg Leu Leu 
        35                  40                  45              


Glu Ala Asp Ser Lys Ser Met Arg Ser Met Asn Gly Ser Arg Arg Asn 
    50                  55                  60                  


Ser Gly Ser Ser Leu Val Ser Ser Ser Ser Ala Ser Ser Asn Leu Ser 
65                  70                  75                  80  


His Leu Glu Glu Asp Thr Trp Ile Leu Trp Gly Arg Ile Ala Asn Glu 
                85                  90                  95      


Trp Glu Glu Trp Arg Arg Arg Lys Glu Lys Leu Leu Lys Glu Leu Ile 
            100                 105                 110         


Arg Lys Gly Ile Pro His His Phe Arg Ala Ile Val Trp Gln Leu Leu 
        115                 120                 125             


Cys Ser Ala Thr Asp Met Pro Val Lys Asn Gln Tyr Ser Glu Leu Leu 
    130                 135                 140                 


Lys Met Ser Ser Pro Cys Glu Lys Leu Ile Arg Arg Asp Ile Ala Arg 
145                 150                 155                 160 


Thr Tyr Pro Glu His Glu Phe Phe Lys Gly Gln Asp Ser Leu Gly Gln 
                165                 170                 175     


Glu Val Leu Phe Asn Val Met Lys Ala Tyr Ser Leu Val Asp Arg Glu 
            180                 185                 190         


Val Gly Tyr Cys Gln Gly Ser Ala Phe Ile Val Gly Leu Leu Leu Met 
        195                 200                 205             


Gln Met Pro Glu Glu Glu Ala Phe Cys Val Phe Val Arg Leu Met Gln 
    210                 215                 220                 


Glu Tyr Arg Leu Arg Glu Leu Phe Lys Pro Ser Met Ala Glu Leu Gly 
225                 230                 235                 240 


Leu Cys Ile Tyr Gln Phe Glu Tyr Met Leu Gln Glu Gln Leu Pro Asp 
                245                 250                 255     


Leu Asn Thr His Phe Arg Ser Gln Ser Phe His Thr Ser Met Tyr Ala 
            260                 265                 270         


Ser Ser Trp Phe Leu Thr Leu Phe Leu Thr Thr Phe Pro Leu Pro Val 
        275                 280                 285             


Ala Thr Arg Val Phe Asp Ile Phe Met Tyr Glu Gly Leu Glu Ile Val 
    290                 295                 300                 


Phe Arg Val Gly Leu Ala Leu Leu Gln Val Asn Gln Ala Glu Leu Met 
305                 310                 315                 320 


Gln Leu Asp Met Glu Gly Met Ser Gln Tyr Phe Gln Arg Val Ile Pro 
                325                 330                 335     


His Gln Phe Asp Ser Cys Pro Asp Lys Leu Val Leu Lys Ala Tyr Gln 
            340                 345                 350         


Val Lys Tyr Asn Pro Lys Lys Met Lys Arg Leu Glu Lys Glu Tyr Ala 
        355                 360                 365             


Ala Met Lys Ser Lys Glu Met Glu Glu Gln Ile Glu Ile Lys Arg Leu 
    370                 375                 380                 


Arg Thr Glu Asn Arg Leu Leu Lys Gln Arg Ile Glu Thr Leu Glu Lys 
385                 390                 395                 400 


Gly Gln Val Thr Arg Ala Gln Glu Ala Glu Glu Asn Tyr Val Ile Lys 
                405                 410                 415     


Arg Glu Leu Ala Val Val Arg Gln Gln Cys Ser Ser Ala Ala Glu Asp 
            420                 425                 430         


Leu Gln Lys Ala Gln Ser Thr Ile Arg Gln Leu Gln Glu Gln Gln Glu 
        435                 440                 445             


Asn Pro Arg Leu Thr Glu Asp Phe Val Ser His Leu Glu Thr Glu Leu 
    450                 455                 460                 


Glu Gln Ser Arg Leu Arg Glu Thr Glu Thr Leu Gly Ala Leu Arg Glu 
465                 470                 475                 480 


Met Gln Asp Lys Val Leu Asp Met Glu Lys Arg Asn Ser Ser Leu Pro 
                485                 490                 495     


Asp Glu Asn Asn Val Ala Gln Leu Gln Glu Glu Leu Lys Ala Leu Lys 
            500                 505                 510         


Val Arg Glu Gly Gln Ala Val Ala Ser Thr Arg Glu Leu Lys Leu Gln 
        515                 520                 525             


Leu Gln Glu Leu Ser Asp Thr Trp Gln Ala His Leu Ala Arg Gly Gly 
    530                 535                 540                 


Arg Trp Lys Glu Ser Pro Arg Lys Leu Val Val Gly Glu Leu Gln Asp 
545                 550                 555                 560 


Glu Leu Met Ser Val Arg Leu Arg Glu Ala Gln Ala Leu Ala Glu Gly 
                565                 570                 575     


Arg Glu Leu Arg Gln Arg Val Val Glu Leu Glu Thr Gln Asp His Ile 
            580                 585                 590         


His Arg Asn Leu Leu Asn Arg Val Glu Ala Glu Arg Ala Ala Leu Gln 
        595                 600                 605             


Glu Lys Leu Gln Tyr Leu Ala Ala Gln Asn Lys Gly Leu Gln Thr Gln 
    610                 615                 620                 


Leu Ser Glu Ser Arg Arg Lys Gln Ala Glu Ala Glu Cys Lys Ser Lys 
625                 630                 635                 640 


Glu Glu Val Met Ala Val Arg Leu Arg Glu Ala Asp Ser Met Ala Ala 
                645                 650                 655     


Val Ala Glu Met Arg Gln Arg Ile Ala Glu Leu Glu Ile Gln Arg Glu 
            660                 665                 670         


Glu Gly Arg Ile Gln Gly Gln Leu Asn His Ser Asp Ser Ser Gln Tyr 
        675                 680                 685             


Ile Arg Glu Leu Lys Asp Gln Ile Glu Glu Leu Lys Ala Glu Val Arg 
    690                 695                 700                 


Leu Leu Lys Gly Pro Pro Pro Phe Glu Asp Pro Leu Ala Phe Asp Gly 
705                 710                 715                 720 


Leu Ser Leu Ala Arg His Leu Asp Glu Asp Ser Leu Pro Ser Ser Asp 
                725                 730                 735     


Glu Glu Leu Leu Gly Val Gly Val Gly Ala Ala Leu Gln Asp Ala Leu 
            740                 745                 750         


Tyr Pro Leu Ser Pro Arg Asp Ala Arg Phe Phe Arg Arg Leu Glu Arg 
        755                 760                 765             


Pro Ala Lys Asp Ser Glu Gly Ser Ser Asp Ser Asp Ala Asp Glu Leu 
    770                 775                 780                 


Ala Ala Pro Tyr Ser Gln Gly Leu Asp Asn 
785                 790                 


<210>  5940
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  5940

Met Gly Lys Glu Ser Gly Trp Asp Ser Gly Arg Ala Ala Val Ala Ala 
1               5                   10                  15      


Val Val Gly Gly Val Val Ala Val Gly Thr Val Leu Val Ala Leu Ser 
            20                  25                  30          


Ala Met Gly Phe Thr Ser Val Gly Ile Ala Ala Ser Ser Ile Ala Ala 
        35                  40                  45              


Lys Met Met Ser Thr Ala Ala Ile Ala Asn Gly Gly Gly Val Ala Ala 
    50                  55                  60                  


Gly Ser Leu Val Ala Ile Leu Gln Ser Val Gly Ala Ala Gly Leu Ser 
65                  70                  75                  80  


Val Thr Ser Lys Val Ile Gly Gly Phe Ala Gly Thr Ala Leu Gly Ala 
                85                  90                  95      


Trp Leu Gly Ser Pro Pro Ser Ser 
            100                 


<210>  5941
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  5941

Met Gly Ala Gln Gly Ala Gln Glu Ser Ile Lys Ala Met Trp Arg Val 
1               5                   10                  15      


Pro Gly Thr Thr Arg Arg Pro Val Thr Gly Glu Ser Pro Gly Met His 
            20                  25                  30          


Arg Pro Glu Ala Met Leu Leu Leu Leu Thr Leu Ala Leu Leu Gly Gly 
        35                  40                  45              


Pro Thr Trp Ala Gly Lys Met Tyr Gly Pro Gly Gly Gly Lys Tyr Phe 
    50                  55                  60                  


Ser Thr Thr Glu Asp Tyr Asp His Glu Ile Thr Gly Leu Arg Val Ser 
65                  70                  75                  80  


Val Gly Leu Leu Leu Val Lys Ser Val Gln Val Lys Leu Gly Asp Ser 
                85                  90                  95      


Trp Asp Val Lys Leu Gly Ala Leu Gly Gly Asn Thr Gln Glu Val Thr 
            100                 105                 110         


Leu Gln Pro Gly Glu Tyr Ile Thr Lys Val Phe Val Ala Phe Gln Ala 
        115                 120                 125             


Phe Leu Arg Gly Met Val Met Tyr Thr Ser Lys Asp Arg Tyr Phe Tyr 
    130                 135                 140                 


Phe Gly Lys Leu Asp Gly Gln Ile Ser Ser Ala Tyr Pro Ser Gln Glu 
145                 150                 155                 160 


Gly Gln Val Leu Val Gly Ile Tyr Gly Gln Tyr Gln Leu Leu Gly Ile 
                165                 170                 175     


Lys Ser Ile Gly Phe Glu Trp Asn Tyr Pro Leu Glu Glu Pro Thr Thr 
            180                 185                 190         


Glu Pro Pro Val Asn Leu Thr Tyr Ser Ala Asn Ser Pro Val Gly Arg 
        195                 200                 205             


<210>  5942
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  5942

Met Glu Arg Glu Gly Ser Gly Gly Ser Gly Gly Ser Ala Gly Leu Leu 
1               5                   10                  15      


Gln Gln Ile Leu Ser Leu Lys Val Val Pro Arg Val Gly Asn Gly Thr 
            20                  25                  30          


Leu Cys Pro Asn Ser Thr Ser Leu Cys Ser Phe Pro Glu Met Trp Tyr 
        35                  40                  45              


Gly Val Phe Leu Trp Ala Leu Val Ser Ser Leu Phe Phe His Val Pro 
    50                  55                  60                  


Ala Gly Leu Leu Ala Leu Phe Thr Leu Arg His His Lys Tyr Gly Arg 
65                  70                  75                  80  


Phe Met Ser Val Ser Ile Leu Leu Met Gly Ile Val Gly Pro Ile Thr 
                85                  90                  95      


Ala Gly Ile Leu Thr Ser Ala Ala Ile Ala Gly Val Tyr Arg Ala Ala 
            100                 105                 110         


Gly Lys Glu Met Ile Pro Phe Glu Ala Leu Thr Leu Gly Thr Gly Gln 
        115                 120                 125             


Thr Phe Cys Val Leu Val Val Ser Phe Leu Arg Ile Leu Ala Thr Leu 
    130                 135                 140                 


<210>  5943
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  5943

Met Gly Gly Thr Leu Ala Trp Thr Leu Leu Leu Pro Leu Leu Leu Arg 
1               5                   10                  15      


Glu Ser Asp Ser Leu Glu Pro Ser Cys Thr Val Ser Ser Ala Asp Val 
            20                  25                  30          


Asp Trp Asn Ala Glu Phe Ser Ala Thr Cys Leu Asn Phe Ser Gly Leu 
        35                  40                  45              


Ser Leu Ser Leu Pro His Asn Gln Ser Leu Arg Ala Ser Asn Val Ile 
    50                  55                  60                  


Leu Leu Asp Leu Ser Gly Asn Gly Leu Arg Glu Leu Pro Val Thr Phe 
65                  70                  75                  80  


Phe Ala His Leu Gln Lys Leu Glu Val Leu Asn Val Leu Arg Asn Pro 
                85                  90                  95      


Leu Ser Arg Val Asp Gly Ala Leu Ala Ala Arg Cys Asp Leu Asp Leu 
            100                 105                 110         


Gln Ala Asp Cys Asn Cys Ala Leu Glu Ser Trp His Asp Ile Arg Arg 
        115                 120                 125             


Asp Asn Cys Ser Gly Gln Lys Pro Leu Leu Cys Trp Asp Thr Thr Ser 
    130                 135                 140                 


Ser Gln His Asn Leu Ser Ala Phe Leu Glu Val Ser Cys Ala Pro Gly 
145                 150                 155                 160 


Leu Ala Ser Ala Thr Ile Gly Ala Val Val Val Ser Gly Cys Leu Leu 
                165                 170                 175     


Leu Gly Leu Ala Ile Ala Gly Pro Val Leu Ala Trp Arg Leu Trp Arg 
            180                 185                 190         


Cys Arg Val Ala Arg Ser Arg Glu Leu Asn Lys Pro Trp Ala Ala Gln 
        195                 200                 205             


Asp Gly Pro Lys Pro Gly Leu Gly Leu Gln Pro Arg Tyr Gly Ser Arg 
    210                 215                 220                 


Ser Ala Pro Lys Pro Gln Val Ala Val Pro Ser Cys Pro Ser Thr Pro 
225                 230                 235                 240 


Asp Tyr Glu Asn Met Phe Val Gly Gln Pro Ala Ala Glu His Gln Trp 
                245                 250                 255     


Asp Glu Gln Gly Ala His Pro Ser Glu Asp Asn Asp Phe Tyr Ile Asn 
            260                 265                 270         


Tyr Lys Asp Ile Asp Leu Ala Ser Gln Pro Val Tyr Cys Asn Leu Gln 
        275                 280                 285             


Ser Leu Gly Gln Ala Pro Met Asp Glu Glu Glu Tyr Val Ile Pro Gly 
    290                 295                 300                 


His 
305 


<210>  5944
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  5944

Met Thr Arg Ala Leu Cys Ser Ala Leu Arg Gln Ala Leu Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Ala Glu Leu Ser Pro Gly Leu Lys Cys Val Cys Leu Leu 
            20                  25                  30          


Cys Asp Ser Ser Asn Phe Thr Cys Gln Thr Glu Gly Ala Cys Trp Ala 
        35                  40                  45              


Ser Val Met Leu Thr Asn Gly Lys Glu Gln Val Ile Lys Ser Cys Val 
    50                  55                  60                  


Ser Leu Pro Glu Leu Asn Ala Gln Val Phe Cys His Ser Ser Asn Asn 
65                  70                  75                  80  


Val Thr Lys Thr Glu Cys Cys Phe Thr Asp Phe Cys Asn Asn Ile Thr 
                85                  90                  95      


Leu His Leu Pro Thr Ala Ser Pro Asn Ala Pro Lys Leu Gly Pro Met 
            100                 105                 110         


Glu Leu Ala Ile Ile Ile Thr Val Pro Val Cys Leu Leu Ser Ile Ala 
        115                 120                 125             


Ala Met Leu Thr Val Trp Ala Cys Gln Gly Arg Gln Cys Ser Tyr Arg 
    130                 135                 140                 


Lys Lys Lys Arg Pro Asn Val Glu Glu Pro Leu Ser Glu Cys Asn Leu 
145                 150                 155                 160 


Val Asn Ala Gly Lys Thr Leu Lys Asp Leu Ile Tyr Asp Val Thr Ala 
                165                 170                 175     


Ser Gly Ser Gly Ser Gly Leu Pro Leu Leu Val Gln Arg Thr Ile Ala 
            180                 185                 190         


Arg Thr Ile Val Leu Gln Glu Ile Val Gly Lys Gly Arg Phe Gly Glu 
        195                 200                 205             


Val Trp His Gly Arg Trp Cys Gly Glu Asp Val Ala Val Lys Ile Phe 
    210                 215                 220                 


Ser Ser Arg Asp Glu Arg Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln 
225                 230                 235                 240 


Thr Val Met Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp 
                245                 250                 255     


Asn Lys Asp Asn Gly Thr Trp Thr Gln Leu Trp Leu Val Ser Glu Tyr 
            260                 265                 270         


His Glu Gln Gly Ser Leu Tyr Asp Tyr Leu Asn Arg Asn Ile Val Thr 
        275                 280                 285             


Val Ala Gly Met Ile Lys Leu Ala Leu Ser Ile Ala Ser Gly Leu Ala 
    290                 295                 300                 


His Leu His Met Glu Ile Val Gly Thr Gln Gly Lys Pro Ala Ile Ala 
305                 310                 315                 320 


His Arg Asp Ile Lys Ser Lys Asn Ile Leu Val Lys Lys Cys Glu Thr 
                325                 330                 335     


Cys Ala Ile Ala Asp Leu Gly Leu Ala Val Lys His Asp Ser Ile Leu 
            340                 345                 350         


Asn Thr Ile Asp Ile Pro Gln Asn Pro Lys Val Gly Thr Lys Arg Tyr 
        355                 360                 365             


Met Ala Pro Glu Met Leu Asp Asp Thr Met Asn Val Asn Ile Phe Glu 
    370                 375                 380                 


Ser Phe Lys Arg Ala Asp Ile Tyr Ser Val Gly Leu Val Tyr Trp Glu 
385                 390                 395                 400 


Ile Ala Arg Arg Cys Ser Val Gly Gly Ile Val Glu Glu Tyr Gln Leu 
                405                 410                 415     


Pro Tyr Tyr Asp Met Val Pro Ser Asp Pro Ser Ile Glu Glu Met Arg 
            420                 425                 430         


Lys Val Val Cys Asp Gln Lys Phe Arg Pro Ser Ile Pro Asn Gln Trp 
        435                 440                 445             


Gln Ser Cys Glu Ala Leu Arg Val Met Gly Arg Ile Met Arg Glu Cys 
    450                 455                 460                 


Trp Tyr Ala Asn Gly Ala Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys 
465                 470                 475                 480 


Thr Ile Ser Gln Leu Cys Val Lys Glu Asp Cys Lys Ala 
                485                 490             


<210>  5945
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  5945

Met Ala Ser Thr Val Val Ala Val Gly Leu Thr Ile Ala Ala Ala Gly 
1               5                   10                  15      


Phe Ala Gly Arg Tyr Val Leu Gln Ala Met Lys His Met Glu Pro Gln 
            20                  25                  30          


Val Lys Gln Val Phe Gln Ser Leu Pro Lys Ser Ala Phe Ser Gly Gly 
        35                  40                  45              


Tyr Tyr Arg Gly Gly Phe Glu Pro Lys Met Thr Lys Arg Glu Ala Ala 
    50                  55                  60                  


Leu Ile Leu Gly Val Ser Pro Thr Ala Asn Lys Gly Lys Ile Arg Asp 
65                  70                  75                  80  


Ala His Arg Arg Ile Met Leu Leu Asn His Pro Asp Lys Gly Gly Ser 
                85                  90                  95      


Pro Tyr Ile Ala Ala Lys Ile Asn Glu Ala Lys Asp Leu Leu Glu Gly 
            100                 105                 110         


Gln Ala Lys Lys 
        115     


<210>  5946
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  5946

Met Asn Asn Leu Asn Asp Pro Pro Asn Trp Asn Ile Arg Pro Asn Ser 
1               5                   10                  15      


Arg Ala Asp Gly Gly Asp Gly Ser Arg Trp Asn Tyr Ala Leu Leu Val 
            20                  25                  30          


Pro Met Leu Gly Leu Ala Ala Phe Arg Trp Ile Trp Ser Arg Glu Ser 
        35                  40                  45              


Gln Lys Glu Val Glu Lys Glu Arg Glu Ala Tyr Arg Arg Arg Thr Ala 
    50                  55                  60                  


Ala Phe Gln Gln Asp Leu Glu Ala Lys Tyr His Ala Met Ile Ser Glu 
65                  70                  75                  80  


Asn Arg Arg Ala Val Ala Gln Leu Ser Leu Glu Leu Glu Lys Glu Gln 
                85                  90                  95      


Asn Arg Thr Ala Ser Tyr Arg Glu Ala Leu Ile Ser Gln Gly Arg Lys 
            100                 105                 110         


Leu Val Glu Glu Lys Lys Leu Leu Glu Gln Glu Arg Ala Gln Val Met 
        115                 120                 125             


Gln Glu Lys Arg Gln Val Gln Pro Leu Arg Ser Ala Tyr Leu Ser Cys 
    130                 135                 140                 


Leu Gln Arg Glu Glu Asn Trp Gln Arg Arg Ala Arg Leu Leu Leu Lys 
145                 150                 155                 160 


Glu Phe Glu Ala Val Leu Thr Glu Arg Gln Asn Ile Tyr Cys Ser Leu 
                165                 170                 175     


Phe Leu Pro Arg Ser Lys Arg Leu Glu Ile Glu Lys Ser Leu Leu Val 
            180                 185                 190         


Arg Ala Ser Val Asp Pro Val Ala Ala Asp Leu Glu Met Ala Ala Gly 
        195                 200                 205             


Leu Thr Asp Ile Phe Gln His Asp Thr Tyr Cys Gly Asp Val Trp Asn 
    210                 215                 220                 


Thr Asn Lys Arg Gln Asn Gly Arg Leu Met Trp Leu Tyr Leu Lys Tyr 
225                 230                 235                 240 


Trp Glu Leu Val Val Glu Leu Lys Lys Phe Lys Arg Val Glu Glu Ala 
                245                 250                 255     


Ile Leu Glu Lys 
            260 


<210>  5947
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  5947

Met Gly Asp Leu Phe Ser Leu Phe Trp Glu Val Asp Pro Pro Pro Ile 
1               5                   10                  15      


Pro Val Asn Cys Ala Ile Pro Asn Gln Asp Tyr Glu Cys Trp Lys Asp 
            20                  25                  30          


Asp Ser Cys Gly Thr Ile Gly Ser Phe Leu Leu Trp Tyr Phe Val Ile 
        35                  40                  45              


Val Phe Val Leu Met Phe Phe Ser Arg Ala Ser Val Trp Met Ser Glu 
    50                  55                  60                  


Asp Lys Lys Asp Glu Gly Ser Gly Thr Ser Thr Ser Val Arg Lys Ala 
65                  70                  75                  80  


Ser Lys Glu Thr Ser Cys Lys Arg Gln Ser Lys Asp Ser Ala Trp Asp 
                85                  90                  95      


Pro Ser Gln Thr Met Lys Lys Pro Lys Gln Asn Gln Leu Thr Pro Val 
            100                 105                 110         


Thr Asn Ser Glu Val Ala Leu Val Asn Ala Tyr Pro Glu Gln Arg Arg 
        115                 120                 125             


Ala Arg Arg Gln Ser Gln Phe Asn Glu Val Asn Gln Asn Gln His Asp 
    130                 135                 140                 


Ser Asp Thr Thr Glu Tyr Gly Ser Glu Glu Ser Asn Ser Glu Ala Ser 
145                 150                 155                 160 


Ser Trp Lys Glu Ser Glu Ser Glu His His Pro Ser Pro Asp Ser Ile 
                165                 170                 175     


Lys Arg Arg Lys Met Ala Gln Arg Gln Arg Asn Leu Gly Ser Tyr Gln 
            180                 185                 190         


Met Ser Glu Arg His Cys Leu His Cys Lys Ala Leu Arg Thr Asn Glu 
        195                 200                 205             


Trp Leu Ala His His Ser Arg Gln Lys Pro Ser Val Thr Pro Pro Met 
    210                 215                 220                 


Lys Arg Asp Ser Gln Glu Glu Ser Ser Ile Ser Asp Ile Asn Lys Lys 
225                 230                 235                 240 


Phe Ser Lys Phe 
                


<210>  5948
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  5948

Met Arg Leu Leu Val Leu Leu Trp Gly Cys Leu Leu Leu Pro Gly Tyr 
1               5                   10                  15      


Glu Ala Leu Glu Gly Pro Glu Glu Ile Ser Gly Phe Glu Gly Asp Thr 
            20                  25                  30          


Val Ser Leu Gln Cys Thr Tyr Arg Glu Glu Leu Arg Asp His Arg Lys 
        35                  40                  45              


Tyr Trp Cys Arg Lys Gly Gly Ile Leu Phe Ser Arg Cys Ser Gly Thr 
    50                  55                  60                  


Ile Tyr Ala Glu Glu Glu Gly Gln Glu Thr Met Lys Gly Arg Val Ser 
65                  70                  75                  80  


Ile Arg Asp Ser Arg Gln Glu Leu Ser Leu Ile Val Thr Leu Trp Asn 
                85                  90                  95      


Leu Thr Leu Gln Asp Ala Gly Glu Tyr Trp Cys Gly Val Glu Lys Arg 
            100                 105                 110         


Gly Pro Asp Glu Ser Leu Leu Ile Ser Leu Phe Val Phe Pro Gly Pro 
        115                 120                 125             


Cys Cys Pro Pro Ser Pro Ser Pro Thr Phe Gln Pro Leu Ala Thr Thr 
    130                 135                 140                 


Arg Leu Gln Pro Lys Ala Lys Ala Gln Gln Thr Gln Pro Pro Gly Leu 
145                 150                 155                 160 


Thr Ser Pro Gly Leu Tyr Pro Ala Ala Thr Thr Ala Lys Gln Gly Lys 
                165                 170                 175     


Thr Gly Ala Glu Ala Pro Pro Leu Pro Gly Thr Ser Gln Tyr Gly His 
            180                 185                 190         


Glu Arg Thr Ser Gln Tyr Thr Gly Thr Ser Pro His Pro Ala Thr Ser 
        195                 200                 205             


Pro Pro Ala Gly Ser Ser Arg Pro Pro Met Gln Leu Asp Ser Thr Ser 
    210                 215                 220                 


Ala Glu Asp Thr Ser Pro Ala Leu Ser Ser Gly Ser Ser Lys Pro Arg 
225                 230                 235                 240 


Val Ser Ile Pro Met Val Arg Ile Leu Ala Pro Val Leu Val Leu Leu 
                245                 250                 255     


Ser Leu Leu Ser Ala Ala Gly Leu Ile Ala Phe Cys Ser His Leu Leu 
            260                 265                 270         


Leu Trp Arg Lys Glu Ala Gln Gln Ala Thr Glu Thr Gln Arg Asn Glu 
        275                 280                 285             


Lys Phe Cys Leu Ser Arg Leu Thr Ala Glu Glu Lys Glu Ala Pro Ser 
    290                 295                 300                 


Gln Ala Pro Glu Gly Asp Val Ile Ser Met Pro Pro Leu His Thr Ser 
305                 310                 315                 320 


Glu Glu Glu Leu Gly Phe Ser Lys Phe Val Ser Ala 
                325                 330         


<210>  5949
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  5949

Met Val Gly Ile Leu Pro Leu Cys Cys Ser Gly Cys Val Pro Ser Leu 
1               5                   10                  15      


Cys Cys Ser Ser Tyr Val Pro Ser Val Ala Pro Thr Ala Ala His Ser 
            20                  25                  30          


Val Arg Val Pro His Ser Ala Gly His Cys Gly Gln Arg Val Leu Ala 
        35                  40                  45              


Cys Ser Leu Pro Gln Val Phe Leu Lys Pro Trp Ile Phe Val Glu His 
    50                  55                  60                  


Phe Ser Ser Trp Leu Ser Leu Glu Leu Phe Ser Phe Leu Arg Tyr Leu 
65                  70                  75                  80  


Gly Thr Leu Leu Cys Ala Cys Gly His Arg Leu Arg Glu Gly Leu Leu 
                85                  90                  95      


Leu Pro Cys Leu Leu Gly Val Gly Ser Trp Leu Leu Phe Asn Asn Trp 
            100                 105                 110         


Thr Gly Gly Ser Trp Phe Ser Leu His Leu Gln Gln Val Ser Leu Ser 
        115                 120                 125             


Gln Gly Ser His Val Ala Ala Phe Leu Pro Glu Ala Ile Gly Pro Gly 
    130                 135                 140                 


Val Pro Val Pro Val Ser Gly Glu Ser Thr Ser Ala Gln Gln Ser His 
145                 150                 155                 160 


Ala Gly Trp Gln Leu Ser Ala Glu Ala Asp Ala Cys Pro Ser Val Leu 
                165                 170                 175     


Tyr Ser Glu Val Leu Glu Trp Asn Lys Asn Ile Asn Thr Tyr Thr Ser 
            180                 185                 190         


Phe His Asp Phe Cys Leu Ile Leu Gly Ile Phe Leu Phe Cys Phe Val 
        195                 200                 205             


Leu Ala Val Ile Gly Leu Pro Tyr Ile Lys Pro Gly Leu Ser Leu Ser 
    210                 215                 220                 


Val Ala Leu Leu Trp Gln Ser Leu Ile Leu Leu Ser Ser Leu Val Gln 
225                 230                 235                 240 


Gln Asp Ser Gln Val His Thr Trp Gly Cys Leu Phe Ser Thr Phe Thr 
                245                 250                 255     


Ser Thr 
        


<210>  5950
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  5950

Met Ile Gln His Asn Cys Ser Arg Gln Gly Pro Thr Ala Pro Pro Pro 
1               5                   10                  15      


Pro Arg Gly Pro Ala Leu Pro Gly Ala Gly Ser Gly Leu Pro Ala Pro 
            20                  25                  30          


Asp Pro Cys Asp Tyr Glu Gly Arg Phe Ser Arg Leu His Gly Arg Pro 
        35                  40                  45              


Pro Gly Phe Leu His Cys Ala Ser Phe Gly Asp Pro His Val Arg Ser 
    50                  55                  60                  


Phe His His His Phe His Thr Cys Arg Val Gln Gly Ala Trp Pro Leu 
65                  70                  75                  80  


Leu Asp Asn Asp Phe Leu Phe Val Gln Ala Thr Ser Ser Pro Met Ala 
                85                  90                  95      


Leu Gly Ala Asn Ala Thr Ala Thr Arg Lys Leu Thr Ile Ile Phe Lys 
            100                 105                 110         


Asn Met Gln Glu Cys Ile Asp Gln Lys Val Tyr Gln Ala Glu Val Asp 
        115                 120                 125             


Asn Leu Pro Val Ala Phe Glu Asp Gly Ser Ile Asn Gly Gly Asp Arg 
    130                 135                 140                 


Pro Gly Gly Ser Ser Leu Ser Ile Gln Thr Ala Asn Pro Gly Asn His 
145                 150                 155                 160 


Val Glu Ile Gln Ala Ala Tyr Ile Gly Thr Thr Ile Ile Ile Arg Gln 
                165                 170                 175     


Thr Ala Gly Gln Leu Ser Phe Ser Ile Lys Val Ala Glu Asp Val Ala 
            180                 185                 190         


Met Ala Phe Ser Ala Glu Gln Asp Leu Gln Leu Cys Val Gly Gly Cys 
        195                 200                 205             


Pro Pro Ser Gln Arg Leu Ser Arg Ser Glu Arg Asn Arg Arg Gly Ala 
    210                 215                 220                 


Ile Thr Ile Asp Thr Ala Arg Arg Leu Cys Lys Glu Gly Leu Pro Val 
225                 230                 235                 240 


Glu Asp Ala Tyr Phe His Ser Cys Val Phe Asp Val Leu Ile Ser Gly 
                245                 250                 255     


Asp Pro Asn Phe Thr Val Ala Ala Gln Ala Ala Leu Glu Asp Ala Arg 
            260                 265                 270         


Ala Phe Leu Pro Asp Leu Glu Lys Leu His Leu Phe Pro Ser Asp Ala 
        275                 280                 285             


Gly Val Pro Leu Ser Ser Ala Thr Leu Leu Ala Pro Leu Leu Ser Gly 
    290                 295                 300                 


Leu Phe Val Leu Trp Leu Cys Ile Gln 
305                 310             


<210>  5951
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  5951

Met Ala Leu Val Pro Tyr Glu Glu Thr Thr Glu Phe Gly Leu Gln Lys 
1               5                   10                  15      


Phe His Lys Pro Leu Ala Thr Phe Ser Phe Ala Asn His Thr Ile Gln 
            20                  25                  30          


Ile Arg Gln Asp Trp Arg His Leu Gly Val Ala Ala Val Val Trp Asp 
        35                  40                  45              


Ala Ala Ile Val Leu Ser Thr Tyr Leu Glu Met Gly Ala Val Glu Leu 
    50                  55                  60                  


Arg Gly Arg Ser Ala Val Glu Leu Gly Ala Gly Thr Gly Leu Val Gly 
65                  70                  75                  80  


Ile Val Ala Ala Leu Leu Gly Ala His Val Thr Ile Thr Asp Arg Lys 
                85                  90                  95      


Val Ala Leu Glu Phe Leu Lys Ser Asn Val Gln Ala Asn Leu Pro Pro 
            100                 105                 110         


His Ile Gln Thr Lys Thr Val Val Lys Glu Leu Thr Trp Gly Gln Asn 
        115                 120                 125             


Leu Gly Ser Phe Ser Pro Gly Glu Phe Asp Leu Ile Leu Gly Ala Asp 
    130                 135                 140                 


Ile Ile Tyr Leu Glu Glu Thr Phe Thr Asp Leu Leu Gln Thr Leu Glu 
145                 150                 155                 160 


His Leu Cys Ser Asn His Ser Val Ile Leu Leu Ala Cys Arg Ile Arg 
                165                 170                 175     


Tyr Glu Arg Asp Asn Asn Phe Leu Ala Met Leu Glu Arg Gln Phe Thr 
            180                 185                 190         


Val Arg Lys Val His Tyr Asp Pro Glu Lys Asp Val His Ile Tyr Glu 
        195                 200                 205             


Ala Gln Lys Arg Asn Gln Lys Glu Asp Leu 
    210                 215             


<210>  5952
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  5952

Met Gly Ser Phe Gln Leu Glu Asp Phe Ala Ala Gly Trp Ile Gly Gly 
1               5                   10                  15      


Ala Ala Ser Val Ile Val Gly His Pro Leu Asp Thr Val Lys Thr Arg 
            20                  25                  30          


Leu Gln Ala Gly Val Gly Tyr Gly Asn Thr Leu Ser Cys Ile Arg Val 
        35                  40                  45              


Val Tyr Arg Arg Glu Ser Met Phe Gly Phe Phe Lys Gly Met Ser Phe 
    50                  55                  60                  


Pro Leu Ala Ser Ile Ala Val Tyr Asn Ser Val Val Phe Gly Val Phe 
65                  70                  75                  80  


Ser Asn Thr Gln Arg Phe Leu Ser Gln His Arg Cys Gly Glu Pro Glu 
                85                  90                  95      


Ala Ser Pro Pro Arg Thr Leu Ser Asp Leu Leu Leu Ala Ser Met Val 
            100                 105                 110         


Ala Gly Val Val Ser Val Gly Leu Gly Gly Pro Val Asp Leu Ile Lys 
        115                 120                 125             


Ile Arg Leu Gln Met Gln Thr Gln Pro Phe Arg Asp Gly Gly Glu His 
    130                 135                 140                 


Arg Met Thr Thr Val Phe Pro Gly Pro His Leu Cys Met 
145                 150                 155         


<210>  5953
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  5953

Met Asp Ser Arg Val Ser Ser Pro Glu Lys Gln Asp Lys Glu Asn Phe 
1               5                   10                  15      


Val Gly Val Asn Asn Lys Arg Leu Gly Val Cys Gly Trp Ile Leu Phe 
            20                  25                  30          


Ser Leu Ser Phe Leu Leu Val Ile Ile Thr Phe Pro Ile Ser Ile Trp 
        35                  40                  45              


Met Cys Leu Lys Ile Ile Lys Glu Tyr Glu Arg Ala Val Val Phe Arg 
    50                  55                  60                  


Leu Gly Arg Ile Gln Ala Asp Lys Ala Lys Gly Pro Gly Leu Ile Leu 
65                  70                  75                  80  


Val Leu Pro Cys Ile Asp Val Phe Val Lys Val Asp Leu Arg Thr Val 
                85                  90                  95      


Thr Cys Asn Ile Pro Pro Gln Glu Ile Leu Thr Arg Asp Ser Val Thr 
            100                 105                 110         


Thr Gln Val Asp Gly Val Val Tyr Tyr Arg Ile Tyr Ser Ala Val Ser 
        115                 120                 125             


Ala Val Ala Asn Val Asn Asp Val His Gln Ala Thr Phe Leu Leu Ala 
    130                 135                 140                 


Gln Thr Thr Leu Arg Asn Val Leu Gly Thr Gln Thr Leu Ser Gln Ile 
145                 150                 155                 160 


Leu Ala Gly Arg Glu Glu Ile Ala His Ser Ile Gln Thr Leu Leu Asp 
                165                 170                 175     


Asp Ala Thr Glu Leu Trp Gly Ile Arg Val Ala Arg Val Glu Ile Lys 
            180                 185                 190         


Asp Val Arg Ile Pro Val Gln Leu Gln Arg Ser Met Ala Ala Glu Ala 
        195                 200                 205             


Glu Ala Thr Arg Glu Ala Arg Ala Lys Val Leu Ala Ala Glu Gly Glu 
    210                 215                 220                 


Met Asn Ala Ser Lys Ser Leu Lys Ser Ala Ser Met Val Leu Ala Glu 
225                 230                 235                 240 


Ser Pro Ile Ala Leu Gln Leu Arg Tyr Leu Gln Thr Leu Ser Thr Val 
                245                 250                 255     


Ala Thr Glu Lys Asn Ser Thr Ile Val Phe Pro Leu Pro Met Asn Ile 
            260                 265                 270         


Leu Glu Gly Ile Gly Gly Val Ser Tyr Asp Asn His Lys Lys Leu Pro 
        275                 280                 285             


Asn Lys Ala 
    290     


<210>  5954
<211>  1321
<212>  PRT
<213>  Homo sapiens

<400>  5954

Met Glu Pro Pro Gly Arg Arg Arg Gly Arg Ala Gln Pro Pro Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ser Leu Leu Ala Leu Leu Ala Leu Leu Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Ala Ala Leu Pro Ala Gly Cys Lys His Asp Gly Arg 
        35                  40                  45              


Pro Arg Gly Ala Gly Arg Ala Ala Gly Ala Ala Glu Gly Lys Val Val 
    50                  55                  60                  


Cys Ser Ser Leu Glu Leu Ala Gln Val Leu Pro Pro Asp Thr Leu Pro 
65                  70                  75                  80  


Asn Arg Thr Val Thr Leu Ile Leu Ser Asn Asn Lys Ile Ser Glu Leu 
                85                  90                  95      


Lys Asn Gly Ser Phe Ser Gly Leu Ser Leu Leu Glu Arg Leu Asp Leu 
            100                 105                 110         


Arg Asn Asn Leu Ile Ser Ser Ile Asp Pro Gly Ala Phe Trp Gly Leu 
        115                 120                 125             


Ser Ser Leu Lys Arg Leu Asp Leu Thr Asn Asn Arg Ile Gly Cys Leu 
    130                 135                 140                 


Asn Ala Asp Ile Phe Arg Gly Leu Thr Asn Leu Val Arg Leu Asn Leu 
145                 150                 155                 160 


Ser Gly Asn Leu Phe Ser Ser Leu Ser Gln Gly Thr Phe Asp Tyr Leu 
                165                 170                 175     


Ala Ser Leu Arg Ser Leu Glu Phe Gln Thr Glu Tyr Leu Leu Cys Asp 
            180                 185                 190         


Cys Asn Ile Leu Trp Met His Arg Trp Val Lys Glu Lys Asn Ile Thr 
        195                 200                 205             


Val Arg Asp Thr Arg Cys Val Tyr Pro Lys Ser Leu Gln Ala Gln Pro 
    210                 215                 220                 


Val Thr Gly Val Lys Gln Glu Leu Leu Thr Cys Asp Pro Pro Leu Glu 
225                 230                 235                 240 


Leu Pro Ser Phe Tyr Met Thr Pro Ser His Arg Gln Val Val Phe Glu 
                245                 250                 255     


Gly Asp Ser Leu Pro Phe Gln Cys Met Ala Ser Tyr Ile Asp Gln Asp 
            260                 265                 270         


Met Gln Val Leu Trp Tyr Gln Asp Gly Arg Ile Val Glu Thr Asp Glu 
        275                 280                 285             


Ser Gln Gly Ile Phe Val Glu Lys Asn Met Ile His Asn Cys Ser Leu 
    290                 295                 300                 


Ile Ala Ser Ala Leu Thr Ile Ser Asn Ile Gln Ala Gly Ser Thr Gly 
305                 310                 315                 320 


Asn Trp Gly Cys His Val Gln Thr Lys Arg Gly Asn Asn Thr Arg Thr 
                325                 330                 335     


Val Asp Ile Val Val Leu Glu Ser Ser Ala Gln Tyr Cys Pro Pro Glu 
            340                 345                 350         


Arg Val Val Asn Asn Lys Gly Asp Phe Arg Trp Pro Arg Thr Leu Ala 
        355                 360                 365             


Gly Ile Thr Ala Tyr Leu Gln Cys Thr Arg Asn Thr His Gly Ser Gly 
    370                 375                 380                 


Ile Tyr Pro Gly Asn Pro Gln Asp Glu Arg Lys Ala Trp Arg Arg Cys 
385                 390                 395                 400 


Asp Arg Gly Gly Phe Trp Ala Asp Asp Asp Tyr Ser Arg Cys Gln Tyr 
                405                 410                 415     


Ala Asn Asp Val Thr Arg Val Leu Tyr Met Phe Asn Gln Met Pro Leu 
            420                 425                 430         


Asn Leu Thr Asn Ala Val Ala Thr Ala Arg Gln Leu Leu Ala Tyr Thr 
        435                 440                 445             


Val Glu Ala Ala Asn Phe Ser Asp Lys Met Asp Val Ile Phe Val Ala 
    450                 455                 460                 


Glu Met Ile Glu Lys Phe Gly Arg Phe Thr Lys Glu Glu Lys Ser Lys 
465                 470                 475                 480 


Glu Leu Gly Asp Val Met Val Asp Ile Ala Ser Asn Ile Met Leu Ala 
                485                 490                 495     


Asp Glu Arg Val Leu Trp Leu Ala Gln Arg Glu Ala Lys Ala Cys Ser 
            500                 505                 510         


Arg Ile Val Gln Cys Leu Gln Arg Ile Ala Thr Tyr Arg Leu Ala Gly 
        515                 520                 525             


Gly Ala His Val Tyr Ser Thr Tyr Ser Pro Asn Ile Ala Leu Glu Ala 
    530                 535                 540                 


Tyr Val Ile Lys Ser Thr Gly Phe Thr Gly Met Thr Cys Thr Val Phe 
545                 550                 555                 560 


Gln Lys Val Ala Ala Ser Asp Arg Thr Gly Leu Ser Asp Tyr Gly Arg 
                565                 570                 575     


Arg Asp Pro Glu Gly Asn Leu Asp Lys Gln Leu Ser Phe Lys Cys Asn 
            580                 585                 590         


Val Ser Asn Thr Phe Ser Ser Leu Ala Leu Lys Asn Thr Ile Val Glu 
        595                 600                 605             


Ala Ser Ile Gln Leu Pro Pro Ser Leu Phe Ser Pro Lys Gln Lys Arg 
    610                 615                 620                 


Glu Leu Arg Pro Thr Asp Asp Ser Leu Tyr Lys Leu Gln Leu Ile Ala 
625                 630                 635                 640 


Phe Arg Asn Gly Lys Leu Phe Pro Ala Thr Gly Asn Ser Thr Asn Leu 
                645                 650                 655     


Ala Asp Asp Gly Lys Arg Arg Thr Val Val Thr Pro Val Ile Leu Thr 
            660                 665                 670         


Lys Ile Asp Gly Val Asn Val Asp Thr His His Ile Pro Val Asn Val 
        675                 680                 685             


Thr Leu Arg Arg Ile Ala His Gly Ala Asp Ala Val Ala Ala Arg Trp 
    690                 695                 700                 


Asp Phe Asp Leu Leu Asn Gly Gln Gly Gly Trp Lys Ser Asp Gly Cys 
705                 710                 715                 720 


His Ile Leu Tyr Ser Asp Glu Asn Ile Thr Thr Ile Gln Cys Tyr Ser 
                725                 730                 735     


Leu Ser Asn Tyr Ala Val Leu Met Asp Leu Thr Gly Ser Glu Leu Tyr 
            740                 745                 750         


Thr Gln Ala Ala Ser Leu Leu His Pro Val Val Tyr Thr Thr Ala Ile 
        755                 760                 765             


Ile Leu Leu Leu Cys Leu Leu Ala Val Ile Val Ser Tyr Ile Tyr His 
    770                 775                 780                 


His Ser Leu Ile Arg Ile Ser Leu Lys Ser Trp His Met Leu Val Asn 
785                 790                 795                 800 


Leu Cys Phe His Ile Phe Leu Thr Cys Val Val Phe Val Gly Gly Ile 
                805                 810                 815     


Thr Gln Thr Arg Asn Ala Ser Ile Cys Gln Ala Val Gly Ile Ile Leu 
            820                 825                 830         


His Tyr Ser Thr Leu Ala Thr Val Leu Trp Val Gly Val Thr Ala Arg 
        835                 840                 845             


Asn Ile Tyr Lys Gln Val Thr Lys Lys Ala Lys Arg Cys Gln Asp Pro 
    850                 855                 860                 


Asp Glu Pro Pro Pro Pro Pro Arg Pro Met Leu Arg Phe Tyr Leu Ile 
865                 870                 875                 880 


Gly Gly Gly Ile Pro Ile Ile Val Cys Gly Ile Thr Ala Ala Ala Asn 
                885                 890                 895     


Ile Lys Asn Tyr Gly Ser Arg Pro Asn Ala Pro Tyr Cys Trp Met Ala 
            900                 905                 910         


Trp Glu Pro Ser Leu Gly Ala Phe Tyr Gly Pro Ala Ser Phe Ile Thr 
        915                 920                 925             


Phe Val Asn Cys Met Tyr Phe Leu Ser Ile Phe Ile Gln Leu Lys Arg 
    930                 935                 940                 


His Pro Glu Arg Lys Tyr Glu Leu Lys Glu Pro Thr Glu Glu Gln Gln 
945                 950                 955                 960 


Arg Leu Ala Ala Asn Glu Asn Gly Glu Ile Asn His Gln Asp Ser Met 
                965                 970                 975     


Ser Leu Ser Leu Ile Ser Thr Ser Ala Leu Glu Asn Glu His Thr Phe 
            980                 985                 990         


His Ser Gln Leu Leu Gly Ala Ser  Leu Thr Leu Leu Leu  Tyr Val Ala 
        995                 1000                 1005             


Leu Trp  Met Phe Gly Ala Leu  Ala Val Ser Leu Tyr  Tyr Pro Leu 
    1010                 1015                 1020             


Asp Leu  Val Phe Ser Phe Val  Phe Gly Ala Thr Ser  Leu Ser Phe 
    1025                 1030                 1035             


Ser Ala  Phe Phe Val Val His  His Cys Val Asn Arg  Glu Asp Val 
    1040                 1045                 1050             


Arg Leu  Ala Trp Ile Met Thr  Cys Cys Pro Gly Arg  Ser Ser Tyr 
    1055                 1060                 1065             


Ser Val  Gln Val Asn Val Gln  Pro Pro Asn Ser Asn  Gly Thr Asn 
    1070                 1075                 1080             


Gly Glu  Ala Pro Lys Cys Pro  Asn Ser Ser Ala Glu  Ser Ser Cys 
    1085                 1090                 1095             


Thr Asn  Lys Ser Ala Ser Ser  Phe Lys Asn Ser Ser  Gln Gly Cys 
    1100                 1105                 1110             


Lys Leu  Thr Asn Leu Gln Ala  Ala Ala Ala Gln Cys  His Ala Asn 
    1115                 1120                 1125             


Ser Leu  Pro Leu Asn Ser Thr  Pro Gln Leu Asp Asn  Ser Leu Thr 
    1130                 1135                 1140             


Glu His  Ser Met Asp Asn Asp  Ile Lys Met His Val  Ala Pro Leu 
    1145                 1150                 1155             


Glu Val  Gln Phe Arg Thr Asn  Val His Ser Ser Arg  His His Lys 
    1160                 1165                 1170             


Asn Arg  Ser Lys Gly His Arg  Ala Ser Arg Leu Thr  Val Leu Arg 
    1175                 1180                 1185             


Glu Tyr  Ala Tyr Asp Val Pro  Thr Ser Val Glu Gly  Ser Val Gln 
    1190                 1195                 1200             


Asn Gly  Leu Pro Lys Ser Arg  Leu Gly Asn Asn Glu  Gly His Ser 
    1205                 1210                 1215             


Arg Ser  Arg Arg Ala Tyr Leu  Ala Tyr Arg Glu Arg  Gln Tyr Asn 
    1220                 1225                 1230             


Pro Pro  Gln Gln Asp Ser Ser  Asp Ala Cys Ser Thr  Leu Pro Lys 
    1235                 1240                 1245             


Ser Ser  Arg Asn Phe Glu Lys  Pro Val Ser Thr Thr  Ser Lys Lys 
    1250                 1255                 1260             


Asp Ala  Leu Arg Lys Pro Ala  Val Val Glu Leu Glu  Asn Gln Gln 
    1265                 1270                 1275             


Lys Ser  Tyr Gly Leu Asn Leu  Ala Ile Gln Asn Gly  Pro Ile Lys 
    1280                 1285                 1290             


Ser Asn  Gly Gln Glu Gly Pro  Leu Leu Gly Thr Asp  Ser Thr Gly 
    1295                 1300                 1305             


Asn Val  Arg Thr Gly Leu Trp  Lys His Glu Thr Thr  Val 
    1310                 1315                 1320     


<210>  5955
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  5955

Met Arg Asn Ala Ile Ile Gln Gly Leu Phe Tyr Gly Ser Leu Thr Phe 
1               5                   10                  15      


Gly Ile Trp Thr Ala Leu Leu Phe Ile Tyr Leu His His Asn His Val 
            20                  25                  30          


Ser Ser Trp Gln Lys Lys Ser Gln Glu Pro Leu Ser Ala Trp Ser Pro 
        35                  40                  45              


Gly Lys Lys Val His Gln Gln Ile Ile Tyr Gly Ser Glu Gln Ile Pro 
    50                  55                  60                  


Lys Pro His Val Ile Val Lys Arg Thr Asp Glu Asp Lys Ala Lys Ser 
65                  70                  75                  80  


Met Leu Gly Thr Asp Phe Asn His Thr Asn Pro Glu Leu His Lys Glu 
                85                  90                  95      


Leu Leu Lys Tyr Gly Phe Asn Val Ile Ile Ser Arg Ser Leu Gly Ile 
            100                 105                 110         


Glu Arg Glu Val Pro Asp Thr Arg Ser Lys Met Cys Leu Gln Lys His 
        115                 120                 125             


Tyr Pro Ala Arg Leu Pro Thr Ala Ser Ile Val Ile Cys Phe Tyr Asn 
    130                 135                 140                 


Glu Glu Cys Asn Ala Leu Phe Gln Thr Met Ser Ser Val Thr Asn Leu 
145                 150                 155                 160 


Thr Pro His Tyr Phe Leu Glu Glu Ile Ile Leu Val Asp Asp Met Ser 
                165                 170                 175     


Lys Val Asp Asp Leu Lys Glu Lys Leu Asp Tyr His Leu Glu Thr Phe 
            180                 185                 190         


Arg Gly Lys Val Lys Ile Ile Arg Asn Lys Lys Arg Glu Gly Leu Ile 
        195                 200                 205             


Arg Ala Arg Leu Ile Gly Ala Ser His Ala Ser Gly Asp Val Leu Val 
    210                 215                 220                 


Phe Leu Asp Ser His Cys Glu Val Asn Arg Val Trp Leu Glu Pro Leu 
225                 230                 235                 240 


Leu His Ala Ile Ala Lys Asp Pro Lys Met Val Val Cys Pro Leu Ile 
                245                 250                 255     


Asp Val Ile Asp Asp Arg Thr Leu Glu Tyr Lys Pro Ser Pro Leu Val 
            260                 265                 270         


Arg Gly Thr Phe Asp Trp Asn Leu Gln Phe Lys Trp Asp Asn Val Phe 
        275                 280                 285             


Ser Tyr Glu Met Asp Gly Pro Glu Gly Ser Thr Lys Pro Ile Arg Ser 
    290                 295                 300                 


Pro Ala Met Ser Gly Gly Ile Phe Ala Ile Arg Arg His Tyr Phe Asn 
305                 310                 315                 320 


Glu Ile Gly Gln Tyr Asp Lys Asp Met Asp Phe Trp Gly Arg Glu Asn 
                325                 330                 335     


Leu Glu Leu Ser Leu Arg Ile Trp Met Cys Gly Gly Gln Leu Phe Ile 
            340                 345                 350         


Ile Pro Cys Ser Arg Val Gly His Ile Ser Lys Lys Gln Thr Gly Lys 
        355                 360                 365             


Pro Ser Thr Ile Ile Ser Ala Met Thr His Asn Tyr Leu Arg Leu Val 
    370                 375                 380                 


His Val Trp Leu Asp Glu Tyr Lys Glu Gln Phe Phe Leu Arg Lys Pro 
385                 390                 395                 400 


Gly Leu Lys Tyr Val Thr Tyr Gly Asn Ile Arg Glu Arg Val Glu Leu 
                405                 410                 415     


Arg Lys Arg Leu Gly Cys Lys Ser Phe Gln Trp Tyr Leu Asp Asn Val 
            420                 425                 430         


Phe Pro Glu Leu Glu Ala Ser Val Asn Ser Leu 
        435                 440             


<210>  5956
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  5956

Met Gly Arg Ala Arg Arg Phe Gln Trp Pro Leu Leu Leu Leu Trp Ala 
1               5                   10                  15      


Ala Ala Ala Gly Pro Gly Ala Gly Gln Glu Val Gln Thr Glu Asn Val 
            20                  25                  30          


Thr Val Ala Glu Gly Gly Val Ala Glu Ile Thr Cys Arg Leu His Gln 
        35                  40                  45              


Tyr Asp Gly Ser Ile Val Val Ile Gln Asn Pro Ala Arg Gln Thr Leu 
    50                  55                  60                  


Phe Phe Asn Gly Thr Arg Ala Leu Lys Asp Glu Arg Phe Gln Leu Glu 
65                  70                  75                  80  


Glu Phe Ser Pro Arg Arg Val Arg Ile Arg Leu Ser Asp Ala Arg Leu 
                85                  90                  95      


Glu Asp Glu Gly Gly Tyr Phe Cys Gln Leu Tyr Thr Glu Asp Thr His 
            100                 105                 110         


His Gln Ile Ala Thr Leu Thr Val Leu Val Ala Pro Glu Asn Pro Val 
        115                 120                 125             


Val Glu Val Arg Glu Gln Ala Val Glu Gly Gly Glu Val Glu Leu Ser 
    130                 135                 140                 


Cys Leu Val Pro Arg Ser Arg Pro Ala Ala Thr Leu Arg Trp Tyr Arg 
145                 150                 155                 160 


Asp Arg Lys Glu Leu Lys Gly Val Ser Ser Ser Gln Glu Asn Gly Lys 
                165                 170                 175     


Val Trp Ser Val Ala Ser Thr Val Arg Phe Arg Val Asp Arg Lys Asp 
            180                 185                 190         


Asp Gly Gly Ile Ile Ile Cys Glu Ala Gln Asn Gln Ala Leu Pro Ser 
        195                 200                 205             


Gly His Ser Lys Gln Thr Gln Tyr Val Leu Asp Val Gln Tyr Ser Pro 
    210                 215                 220                 


Thr Ala Arg Ile His Ala Ser Gln Ala Val Val Arg Glu Gly Asp Thr 
225                 230                 235                 240 


Leu Val Leu Thr Cys Ala Val Thr Gly Asn Pro Arg Pro Asn Gln Ile 
                245                 250                 255     


Arg Trp Asn Arg Gly Asn Glu Ser Leu Pro Glu Arg Ala Glu Ala Val 
            260                 265                 270         


Gly Glu Thr Leu Thr Leu Pro Gly Leu Val Ser Ala Asp Asn Gly Thr 
        275                 280                 285             


Tyr Thr Cys Glu Ala Ser Asn Lys His Gly His Ala Arg Ala Leu Tyr 
    290                 295                 300                 


Val Leu Val Val Tyr Asp Pro Gly Ala Val Val Glu Ala Gln Thr Ser 
305                 310                 315                 320 


Val Pro Tyr Ala Ile Val Gly Gly Ile Leu Ala Leu Leu Val Phe Leu 
                325                 330                 335     


Ile Ile Cys Val Leu Val Gly Met Val Trp Cys Ser Val Arg Gln Lys 
            340                 345                 350         


Gly Ser Tyr Leu Thr His Glu Ala Ser Gly Leu Asp Glu Gln Gly Glu 
        355                 360                 365             


Ala Arg Glu Ala Phe Leu Asn Gly Ser Asp Gly His Lys Arg Lys Glu 
    370                 375                 380                 


Glu Phe Phe Ile 
385             


<210>  5957
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  5957

Met Leu Gln Gln Asp Ser Asn Asp Asp Thr Glu Asp Val Ser Leu Phe 
1               5                   10                  15      


Asp Ala Glu Glu Glu Thr Thr Asn Arg Pro Arg Lys Ala Lys Ile Arg 
            20                  25                  30          


His Pro Val Ala Ser Phe Phe His Leu Phe Phe Arg Val Ser Ala Ile 
        35                  40                  45              


Ile Val Cys Leu Leu Cys Glu Leu Leu Ser Ser Ser Phe Ile Thr Cys 
    50                  55                  60                  


Met Val Thr Ile Ile Leu Leu Leu Ser Cys Asp Phe Trp Ala Val Lys 
65                  70                  75                  80  


Asn Val Thr Gly Arg Leu Met Val Gly Leu Arg Trp Trp Asn His Ile 
                85                  90                  95      


Asp Glu Asp Gly Lys Ser His Trp Val Phe Glu Ser Arg Lys Glu Ser 
            100                 105                 110         


Ser Gln Glu Asn Lys Thr Val Ser Glu Ala Glu Ser Arg Ile Phe Trp 
        115                 120                 125             


Leu Gly Leu Ile Ala Cys Ser Val Leu Trp Val Ile Phe Ala Phe Ser 
    130                 135                 140                 


Ala Leu Phe Ser Phe Thr Val Lys Trp Leu Arg Arg Ser Arg His Ile 
145                 150                 155                 160 


Ala Gln Thr Gly Leu Lys Val Leu Gly Ser Arg Asp Pro Pro Ala Ser 
                165                 170                 175     


Ala Phe Gln Ser Ala Gly Ile Thr Gly Val Ser Arg Cys Pro Gly His 
            180                 185                 190         


Pro Ser Arg Lys Phe His Gln Val Asp Ile Asn Ser Phe Thr Arg Ile 
        195                 200                 205             


Thr Asp Arg Ala Leu Tyr Trp Lys Pro Ala Pro Arg Leu Ser Ser Pro 
    210                 215                 220                 


Pro Leu Arg Ala Ala Pro Gly Asn Cys Gln Gln Met Ala Pro Ala Arg 
225                 230                 235                 240 


Leu Phe Leu Ser Leu Arg Leu Trp Ala Trp Arg Gly Gly Gly Glu Ser 
                245                 250                 255     


Pro Asn Ser Arg Gly Thr Gly Glu Pro Gly Pro Lys Phe His Leu Ala 
            260                 265                 270         


Ser Gly Met His 
        275     


<210>  5958
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  5958

Met Ala Thr Trp Arg Arg Asp Gly Arg Leu Thr Gly Gly Gln Arg Leu 
1               5                   10                  15      


Leu Cys Ala Gly Leu Ala Gly Thr Leu Ser Leu Ser Leu Thr Ala Pro 
            20                  25                  30          


Leu Glu Leu Ala Thr Val Leu Ala Gln Val Gly Val Val Arg Gly His 
        35                  40                  45              


Ala Arg Gly Pro Trp Ala Thr Gly His Arg Val Trp Arg Ala Glu Gly 
    50                  55                  60                  


Leu Arg Ala Leu Trp Lys Gly Asn Ala Val Ala Cys Leu Arg Leu Phe 
65                  70                  75                  80  


Pro Cys Ser Ala Val Gln Leu Ala Ala Tyr Arg Lys Phe Val Val Leu 
                85                  90                  95      


Phe Thr Asp Asp Leu Gly His Ile Ser Gln Trp Ser Ser Ile Met Ala 
            100                 105                 110         


Gly Ser Leu Ala Gly Met Val Ser Thr Ile Val Thr Tyr Pro Thr Asp 
        115                 120                 125             


Leu Ile Lys Thr Arg Leu Ile Met Gln Asn Ile Leu Glu Pro Ser Tyr 
    130                 135                 140                 


Arg Gly Leu Leu His Ala Phe Ser Thr Ile Tyr Gln Gln Glu Gly Phe 
145                 150                 155                 160 


Leu Ala Leu Tyr Arg Gly Val Ser Leu Thr Val Val Gly Ala Leu Pro 
                165                 170                 175     


Phe Ser Ala Gly Ser Leu Leu Val Tyr Met Asn Leu Glu Lys Ile Trp 
            180                 185                 190         


Asn Gly Pro Arg Asp Gln Phe Ser Leu Pro Gln Asn Phe Ala Asn Val 
        195                 200                 205             


Cys Leu Ala Ala Ala Val Thr Gln Thr Leu Ser Phe Pro Phe Glu Thr 
    210                 215                 220                 


Val Lys Arg Lys Met Gln Ala Gln Ser Pro Tyr Leu Pro His Ser Gly 
225                 230                 235                 240 


Gly Val Asp Val His Phe Ser Gly Ala Val Asp Cys Phe Arg Gln Ile 
                245                 250                 255     


Val Lys Ala Gln Gly Val Leu Gly Leu Trp Asn Gly Leu Thr Ala Asn 
            260                 265                 270         


Leu Leu Lys Ile Val Pro Tyr Phe Gly Ile Met Phe Ser Thr Phe Glu 
        275                 280                 285             


Phe Cys Lys Arg Ile Cys Leu Tyr Gln Asn Gly Tyr Ile Leu Ser Pro 
    290                 295                 300                 


Leu Ser Tyr Lys Leu Thr Pro Gly Val Asp Gln Ser Leu Gln Pro Gln 
305                 310                 315                 320 


Glu Leu Arg Glu Leu Lys Lys Phe Phe Lys Thr Arg Lys Pro Lys Pro 
                325                 330                 335     


Lys Lys Pro Thr Leu 
            340     


<210>  5959
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  5959

Met Val Arg Ile Leu Ala Asn Gly Glu Ile Val Gln Asp Asp Asp Pro 
1               5                   10                  15      


Arg Val Arg Thr Thr Thr Gln Pro Pro Arg Gly Ser Ile Pro Arg Gln 
            20                  25                  30          


Ser Phe Phe Asn Arg Gly His Gly Ala Pro Pro Gly Gly Pro Gly Pro 
        35                  40                  45              


Arg Gln Gln Gln Ala Gly Ala Arg Leu Gly Ala Ala Gln Ser Pro Phe 
    50                  55                  60                  


Asn Asp Leu Asn Arg Gln Leu Val Asn Met Gly Phe Pro Gln Trp His 
65                  70                  75                  80  


Leu Gly Asn His Ala Val Glu Pro Val Thr Ser Ile Leu Leu Leu Phe 
                85                  90                  95      


Leu Leu Met Met Leu Gly Val Arg Gly Leu Leu Leu Val Gly Leu Val 
            100                 105                 110         


Tyr Leu Val Ser His Leu Ser Gln Arg 
        115                 120     


<210>  5960
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  5960

Met Asn Lys Arg Asp Tyr Met Asn Thr Ser Val Gln Glu Pro Pro Leu 
1               5                   10                  15      


Asp Tyr Ser Phe Arg Ser Ile His Val Ile Gln Asp Leu Val Asn Glu 
            20                  25                  30          


Glu Pro Arg Thr Gly Leu Arg Pro Leu Lys Arg Ser Lys Ser Gly Lys 
        35                  40                  45              


Ser Leu Thr Gln Ser Leu Trp Leu Asn Asn Asn Val Leu Asn Asp Leu 
    50                  55                  60                  


Arg Asp Phe Asn Gln Val Ala Ser Gln Leu Leu Glu His Pro Glu Asn 
65                  70                  75                  80  


Leu Ala Trp Ile Asp Leu Ser Phe Asn Asp Leu Thr Ser Ile Asp Pro 
                85                  90                  95      


Val Leu Thr Thr Phe Phe Asn Leu Ser Val Leu Tyr Leu His Gly Asn 
            100                 105                 110         


Ser Ile Gln Arg Leu Gly Glu Val Asn Lys Leu Ala Val Leu Pro Arg 
        115                 120                 125             


Leu Arg Ser Leu Thr Leu His Gly Asn Pro Met Glu Glu Glu Lys Gly 
    130                 135                 140                 


Tyr Arg Gln Tyr Val Leu Cys Thr Leu Ser Arg Ile Thr Thr Phe Asp 
145                 150                 155                 160 


Phe Ser Gly Val Thr Lys Ala Asp Arg Thr Thr Ala Glu Val Trp Lys 
                165                 170                 175     


Arg Met Asn Ile Lys Pro Lys Lys Ala Trp Thr Lys Gln Asn Thr Leu 
            180                 185                 190         


<210>  5961
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  5961

Met Lys Gln Gln Gln Trp Cys Gly Met Thr Ala Lys Met Gly Thr Val 
1               5                   10                  15      


Leu Ser Gly Val Phe Thr Ile Met Ala Val Asp Met Tyr Leu Ile Phe 
            20                  25                  30          


Glu Gln Lys His Leu Gly Asn Gly Ser Cys Thr Glu Ile Thr Pro Lys 
        35                  40                  45              


Tyr Arg Gly Ala Ser Asn Ile Ile Asn Asn Phe Ile Ile Cys Trp Ser 
    50                  55                  60                  


Phe Lys Ile Val Leu Phe Leu Ser Phe Ile Thr Ile Leu Ile Ser Cys 
65                  70                  75                  80  


Phe Leu Leu Tyr Ser Val Tyr Ala Gln Ile Phe Arg Gly Leu Val Ile 
                85                  90                  95      


Tyr Ile Val Trp Ile Phe Phe Tyr Glu Thr Ala Asn Val Val Ile Gln 
            100                 105                 110         


Ile Leu Thr Asn Asn Asp Phe Asp Ile Lys Glu Val Arg Ile Met Arg 
        115                 120                 125             


Trp Phe Gly Leu Val Ser Arg Thr Val Met His Cys Phe Trp Met Phe 
    130                 135                 140                 


Phe Val Ile Asn Tyr Ala His Ile Thr Tyr Lys Asn Arg Ser Gln Gly 
145                 150                 155                 160 


Asn Ile Ile Ser Tyr Lys Arg Arg Ile Ser Thr Ala Glu Ile Leu His 
                165                 170                 175     


Ser Arg Asn Lys Arg Leu Ser Ile Ser Ser Gly Phe Ser Gly Ser His 
            180                 185                 190         


Leu Glu Ser Gln Tyr Phe Glu Arg Gln Ser Phe His Thr Ser Ile Phe 
        195                 200                 205             


Thr Cys Leu Ser Pro Val Pro Ser Ser Ala Pro Ser Thr Cys Arg Tyr 
    210                 215                 220                 


Thr Ile Asp Val Cys 
225                 


<210>  5962
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  5962

Met Arg Phe Lys Ser His Thr Val Glu Leu Arg Arg Pro Cys Ser Asp 
1               5                   10                  15      


Met Glu Gly Ala Ala Leu Leu Arg Val Ser Val Leu Cys Ile Trp Met 
            20                  25                  30          


Ser Ala Leu Phe Leu Gly Val Gly Val Arg Ala Glu Glu Ala Gly Ala 
        35                  40                  45              


Arg Val Gln Gln Asn Val Pro Ser Gly Thr Asp Thr Gly Asp Pro Gln 
    50                  55                  60                  


Ser Lys Pro Leu Gly Asp Trp Ala Ala Gly Thr Met Asp Pro Glu Ser 
65                  70                  75                  80  


Ser Ile Phe Ile Glu Asp Ala Ile Lys Tyr Phe Lys Glu Lys Val Ser 
                85                  90                  95      


Thr Gln Asn Leu Leu Leu Leu Leu Thr Asp Asn Glu Ala Trp Asn Gly 
            100                 105                 110         


Phe Val Ala Ala Ala Glu Leu Pro Arg Asn Glu Ala Asp Glu Leu Arg 
        115                 120                 125             


Lys Ala Leu Asp Asn Leu Ala Arg Gln Met Ile Met Lys Asp Lys Asn 
    130                 135                 140                 


Trp His Asp Lys Gly Gln Gln Tyr Arg Asn Trp Phe Leu Lys Glu Phe 
145                 150                 155                 160 


Pro Arg Leu Lys Ser Glu Leu Glu Asp Asn Ile Arg Arg Leu Arg Ala 
                165                 170                 175     


Leu Ala Asp Gly Val Gln Lys Val His Lys Gly Thr Thr Ile Ala Asn 
            180                 185                 190         


Val Val Ser Gly Ser Leu Ser Ile Ser Ser Gly Ile Leu Thr Leu Val 
        195                 200                 205             


Gly Met Gly Leu Ala Pro Phe Thr Glu Gly Gly Ser Leu Val Leu Leu 
    210                 215                 220                 


Glu Pro Gly Met Glu Leu Gly Ile Thr Ala Ala Leu Thr Gly Ile Thr 
225                 230                 235                 240 


Ser Ser Thr Met Asp Tyr Gly Lys Lys Trp Trp Thr Gln Ala Gln Ala 
                245                 250                 255     


His Asp Leu Val Ile Lys Ser Leu Asp Lys Leu Lys Glu Val Arg Glu 
            260                 265                 270         


Phe Leu Gly Glu Asn Ile Ser Asn Phe Leu Ser Leu Ala Gly Asn Thr 
        275                 280                 285             


Tyr Gln Leu Thr Arg Gly Ile Gly Lys Asp Ile Arg Ala Leu Arg Arg 
    290                 295                 300                 


Ala Arg Ala Asn Leu Gln Ser Val Pro His Ala Ser Ala Ser Arg Pro 
305                 310                 315                 320 


Arg Val Thr Glu Pro Ile Ser Ala Glu Ser Gly Glu Gln Val Glu Arg 
                325                 330                 335     


Val Asn Glu Pro Ser Ile Leu Glu Met Ser Arg Gly Val Lys Leu Thr 
            340                 345                 350         


Asp Val Ala Pro Val Ser Phe Phe Leu Val Leu Asp Val Val Tyr Leu 
        355                 360                 365             


Val Tyr Glu Ser Lys His Leu His Glu Gly Ala Lys Ser Glu Thr Ala 
    370                 375                 380                 


Glu Glu Leu Lys Lys Val Ala Gln Glu Leu Glu Glu Lys Leu Asn Ile 
385                 390                 395                 400 


Leu Asn Asn Asn Tyr Lys Ile Leu Gln Ala Asp Gln Glu Leu 
                405                 410                 


<210>  5963
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  5963

Met Asn Pro Glu Ser Ser Ile Phe Ile Glu Asp Tyr Leu Lys Tyr Phe 
1               5                   10                  15      


Gln Asp Gln Val Ser Arg Glu Asn Leu Leu Gln Leu Leu Thr Asp Asp 
            20                  25                  30          


Glu Ala Trp Asn Gly Phe Val Ala Ala Ala Glu Leu Pro Arg Asp Glu 
        35                  40                  45              


Ala Asp Glu Leu Arg Lys Ala Leu Asn Lys Leu Ala Ser His Met Val 
    50                  55                  60                  


Met Lys Asp Lys Asn Arg His Asp Lys Asp Gln Gln His Arg Gln Trp 
65                  70                  75                  80  


Phe Leu Lys Glu Phe Pro Arg Leu Lys Arg Glu Leu Glu Asp His Ile 
                85                  90                  95      


Arg Lys Leu Arg Ala Leu Ala Glu Glu Val Glu Gln Val His Arg Gly 
            100                 105                 110         


Thr Thr Ile Ala Asn Val Val Ser Asn Ser Val Gly Thr Thr Ser Gly 
        115                 120                 125             


Ile Leu Thr Leu Leu Gly Leu Gly Leu Ala Pro Phe Thr Glu Gly Ile 
    130                 135                 140                 


Ser Phe Val Leu Leu Asp Thr Gly Met Gly Leu Gly Ala Ala Ala Ala 
145                 150                 155                 160 


Val Ala Gly Ile Thr Cys Ser Val Val Glu Leu Val Asn Lys Leu Arg 
                165                 170                 175     


Ala Arg Ala Gln Ala Arg Asn Leu Asp Gln Ser Gly Thr Asn Val Ala 
            180                 185                 190         


Lys Val Met Lys Glu Phe Val Gly Gly Asn Thr Pro Asn Val Leu Thr 
        195                 200                 205             


Leu Val Asp Asn Trp Tyr Gln Val Thr Gln Gly Ile Gly Arg Asn Ile 
    210                 215                 220                 


Arg Ala Ile Arg Arg Ala Arg Ala Asn Pro Gln Leu Gly Ala Tyr Ala 
225                 230                 235                 240 


Pro Pro Pro His Val Ile Gly Arg Ile Ser Ala Glu Gly Gly Glu Gln 
                245                 250                 255     


Val Glu Arg Val Val Glu Gly Pro Ala Gln Ala Met Ser Arg Gly Thr 
            260                 265                 270         


Met Ile Val Gly Ala Ala Thr Gly Gly Ile Leu Leu Leu Leu Asp Val 
        275                 280                 285             


Val Ser Leu Ala Tyr Glu Ser Lys His Leu Leu Glu Gly Ala Lys Ser 
    290                 295                 300                 


Glu Ser Ala Glu Glu Leu Lys Lys Arg Ala Gln Glu Leu Glu Gly Lys 
305                 310                 315                 320 


Leu Asn Phe Leu Thr Lys Ile His Glu Met Leu Gln Pro Gly Gln Asp 
                325                 330                 335     


Gln 
    


<210>  5964
<211>  577
<212>  PRT
<213>  Homo sapiens

<400>  5964

Met Glu Gly Ser Gly Gly Gly Ala Gly Glu Arg Ala Pro Leu Leu Gly 
1               5                   10                  15      


Ala Arg Arg Ala Ala Ala Ala Ala Ala Ala Ala Gly Ala Phe Ala Gly 
            20                  25                  30          


Arg Arg Ala Ala Cys Gly Ala Val Leu Leu Thr Glu Leu Leu Glu Arg 
        35                  40                  45              


Ala Ala Phe Tyr Gly Ile Thr Ser Asn Leu Val Leu Phe Leu Asn Gly 
    50                  55                  60                  


Ala Pro Phe Cys Trp Glu Gly Ala Gln Ala Ser Glu Ala Leu Leu Leu 
65                  70                  75                  80  


Phe Met Gly Leu Thr Tyr Leu Gly Ser Pro Phe Gly Gly Trp Leu Ala 
                85                  90                  95      


Asp Ala Arg Leu Gly Arg Ala Arg Ala Ile Leu Leu Ser Leu Ala Leu 
            100                 105                 110         


Tyr Leu Leu Gly Met Leu Ala Phe Pro Leu Leu Ala Ala Pro Ala Thr 
        115                 120                 125             


Arg Ala Ala Leu Cys Gly Ser Ala Arg Leu Leu Asn Cys Thr Ala Pro 
    130                 135                 140                 


Gly Pro Asp Ala Ala Ala Arg Cys Cys Ser Pro Ala Thr Phe Ala Gly 
145                 150                 155                 160 


Leu Val Leu Val Gly Leu Gly Val Ala Thr Val Lys Ala Asn Ile Thr 
                165                 170                 175     


Pro Phe Gly Ala Asp Gln Val Lys Asp Arg Gly Pro Glu Ala Thr Arg 
            180                 185                 190         


Arg Phe Phe Asn Trp Phe Tyr Trp Ser Ile Asn Leu Gly Ala Ile Leu 
        195                 200                 205             


Ser Leu Gly Gly Ile Ala Tyr Ile Gln Gln Asn Val Ser Phe Val Thr 
    210                 215                 220                 


Gly Tyr Ala Ile Pro Thr Val Cys Val Gly Leu Ala Phe Val Val Phe 
225                 230                 235                 240 


Leu Cys Gly Gln Ser Val Phe Ile Thr Lys Pro Pro Asp Gly Ser Ala 
                245                 250                 255     


Phe Thr Asp Met Phe Lys Ile Leu Thr Tyr Ser Cys Cys Ser Gln Lys 
            260                 265                 270         


Arg Ser Gly Glu Arg Gln Ser Asn Gly Glu Gly Ile Gly Val Phe Gln 
        275                 280                 285             


Gln Ser Ser Lys Gln Ser Leu Phe Asp Ser Cys Lys Met Ser His Gly 
    290                 295                 300                 


Gly Pro Phe Thr Glu Glu Lys Val Glu Asp Val Lys Ala Leu Val Lys 
305                 310                 315                 320 


Ile Val Pro Val Phe Leu Ala Leu Ile Pro Tyr Trp Thr Val Tyr Phe 
                325                 330                 335     


Gln Met Gln Thr Thr Tyr Val Leu Gln Ser Leu His Leu Arg Ile Pro 
            340                 345                 350         


Glu Ile Ser Asn Ile Thr Thr Thr Pro His Thr Leu Pro Ala Ala Trp 
        355                 360                 365             


Leu Thr Met Phe Asp Ala Val Leu Ile Leu Leu Leu Ile Pro Leu Lys 
    370                 375                 380                 


Asp Lys Leu Val Asp Pro Ile Leu Arg Arg His Gly Leu Leu Pro Ser 
385                 390                 395                 400 


Ser Leu Lys Arg Ile Ala Val Gly Met Phe Phe Val Met Cys Ser Ala 
                405                 410                 415     


Phe Ala Ala Gly Ile Leu Glu Ser Lys Arg Leu Asn Leu Val Lys Glu 
            420                 425                 430         


Lys Thr Ile Asn Gln Thr Ile Gly Asn Val Val Tyr His Ala Ala Asp 
        435                 440                 445             


Leu Ser Leu Trp Trp Gln Val Pro Gln Tyr Leu Leu Ile Gly Ile Ser 
    450                 455                 460                 


Glu Ile Phe Ala Ser Ile Ala Gly Leu Glu Phe Ala Tyr Ser Ala Ala 
465                 470                 475                 480 


Pro Lys Ser Met Gln Ser Ala Ile Met Gly Leu Phe Phe Phe Phe Ser 
                485                 490                 495     


Gly Val Gly Ser Phe Val Gly Ser Gly Leu Leu Ala Leu Val Ser Ile 
            500                 505                 510         


Lys Ala Ile Gly Trp Met Ser Ser His Thr Asp Phe Gly Asn Ile Asn 
        515                 520                 525             


Gly Cys Tyr Leu Asn Tyr Tyr Phe Phe Leu Leu Ala Ala Ile Gln Gly 
    530                 535                 540                 


Ala Thr Leu Leu Leu Phe Leu Ile Ile Ser Val Lys Tyr Asp His His 
545                 550                 555                 560 


Arg Asp His Gln Arg Ser Arg Ala Asn Gly Val Pro Thr Ser Arg Arg 
                565                 570                 575     


Ala 
    


<210>  5965
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  5965

Met Met Gly Ser Trp Lys His Cys Leu Phe Ser Ala Ser Leu Ile Ser 
1               5                   10                  15      


Ala Leu Ile Phe Val Phe Val Tyr Asn Thr Glu Leu Trp Glu Asn Lys 
            20                  25                  30          


Arg Phe Leu Arg Ala Ala Leu Ser Asn Ala Ser Leu Leu Ala Glu Ala 
        35                  40                  45              


Cys His Gln Ile Phe Glu Gly Lys Val Phe Tyr Pro Thr Glu Asn Ala 
    50                  55                  60                  


Leu Lys Thr Thr Leu Asp Glu Ala Thr Cys Tyr Glu Tyr Met Val Arg 
65                  70                  75                  80  


Ser His Tyr Val Thr Glu Thr Leu Ser Glu Glu Glu Ala Gly Phe Pro 
                85                  90                  95      


Leu Ala Tyr Thr Val Thr Ile His Lys Asp Phe Gly Thr Phe Glu Arg 
            100                 105                 110         


Leu Phe Arg Ala Ile Tyr Met Pro Gln Asn Val Tyr Cys Val His Leu 
        115                 120                 125             


Asp Gln Lys Ala Thr Asp Ala Phe Lys Gly Ala Val Lys Gln Leu Leu 
    130                 135                 140                 


Ser Cys Phe Pro Asn Ala Phe Leu Ala Ser Lys Lys Glu Ser Val Val 
145                 150                 155                 160 


Tyr Gly Gly Ile Ser Arg Leu Gln Ala Asp Leu Asn Cys Leu Glu Asp 
                165                 170                 175     


Leu Val Ala Ser Glu Val Pro Trp Lys Tyr Val Ile Asn Thr Cys Gly 
            180                 185                 190         


Gln Asp Phe Pro Leu Lys Thr Asn Arg Glu Ile Val Gln Tyr Leu Lys 
        195                 200                 205             


Gly Phe Lys Gly Lys Asn Ile Thr Pro Gly Val Leu Pro Pro Asp His 
    210                 215                 220                 


Ala Val Gly Arg Thr Lys Tyr Val His Gln Glu Leu Leu Asn His Lys 
225                 230                 235                 240 


Asn Ser Tyr Val Ile Lys Thr Thr Lys Leu Lys Thr Pro Pro Pro His 
                245                 250                 255     


Asp Met Val Ile Tyr Phe Gly Thr Ala Tyr Val Ala Leu Thr Arg Asp 
            260                 265                 270         


Phe Ala Asn Phe Val Leu Gln Asp Gln Leu Ala Leu Asp Leu Leu Ser 
        275                 280                 285             


Trp Ser Lys Asp Thr Tyr Ser Pro Asp Glu His Phe Trp Val Thr Leu 
    290                 295                 300                 


Asn Arg Ile Pro Gly Val Pro Gly Ser Met Pro Asn Ala Ser Trp Thr 
305                 310                 315                 320 


Gly Asn Leu Arg Ala Ile Lys Trp Ser Asp Met Glu Asp Arg His Gly 
                325                 330                 335     


Gly Cys His Gly His Tyr Val His Gly Ile Cys Ile Tyr Gly Asn Gly 
            340                 345                 350         


Asp Leu Lys Trp Leu Val Asn Ser Pro Ser Leu Phe Ala Asn Lys Phe 
        355                 360                 365             


Glu Leu Asn Thr Tyr Pro Leu Thr Val Glu Cys Leu Glu Leu Arg His 
    370                 375                 380                 


Arg Glu Arg Thr Leu Asn Gln Ser Glu Thr Ala Ile Gln Pro Ser Trp 
385                 390                 395                 400 


Tyr Phe 
        


<210>  5966
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  5966

Met Leu Ala Leu Ala Lys Ile Leu Leu Ile Ser Thr Leu Phe Tyr Ser 
1               5                   10                  15      


Leu Leu Ser Gly Ser His Gly Lys Glu Asn Gln Asp Ile Asn Thr Thr 
            20                  25                  30          


Gln Asn Ile Ala Glu Val Phe Lys Thr Met Glu Asn Lys Pro Ile Ser 
        35                  40                  45              


Leu Glu Ser Glu Ala Asn Leu Asn Ser Asp Lys Glu Asn Ile Thr Thr 
    50                  55                  60                  


Ser Asn Leu Lys Ala Ser His Ser Pro Pro Leu Asn Leu Pro Asn Asn 
65                  70                  75                  80  


Ser His Gly Ile Thr Asp Phe Ser Ser Asn Ser Ser Ala Glu His Ser 
                85                  90                  95      


Leu Gly Ser Leu Lys Pro Thr Ser Thr Ile Ser Thr Ser Pro Pro Leu 
            100                 105                 110         


Ile His Ser Phe Val Ser Lys Val Pro Trp Asn Ala Pro Ile Ala Asp 
        115                 120                 125             


Glu Asp Leu Leu Pro Ile Ser Ala His Pro Asn Ala Thr Pro Ala Leu 
    130                 135                 140                 


Ser Ser Glu Asn Phe Thr Trp Ser Leu Val Asn Asp Thr Val Lys Thr 
145                 150                 155                 160 


Pro Asp Asn Ser Ser Ile Thr Val Ser Ile Leu Ser Ser Glu Pro Thr 
                165                 170                 175     


Ser Pro Ser Val Thr Pro Leu Ile Val Glu Pro Ser Gly Trp Leu Thr 
            180                 185                 190         


Thr Asn Ser Asp Ser Phe Thr Gly Phe Thr Pro Tyr Gln Glu Lys Thr 
        195                 200                 205             


Thr Leu Gln Pro Thr Leu Lys Phe Thr Asn Asn Ser Lys Leu Phe Pro 
    210                 215                 220                 


Asn Thr Ser Asp Pro Gln Lys Glu Asn Arg Asn Thr Gly Ile Val Phe 
225                 230                 235                 240 


Gly Ala Ile Leu Gly Ala Ile Leu Gly Val Ser Leu Leu Thr Leu Val 
                245                 250                 255     


Gly Tyr Leu Leu Cys Gly Lys Arg Lys Thr Asp Ser Phe Ser His Arg 
            260                 265                 270         


Arg Leu Tyr Asp Asp Arg Asn Glu Pro Val Leu Arg Leu Asp Asn Ala 
        275                 280                 285             


Pro Glu Pro Tyr Asp Val Ser Phe Gly Asn Ser Ser Tyr Tyr Asn Pro 
    290                 295                 300                 


Thr Leu Asn Asp Ser Ala Met Pro Glu Ser Glu Glu Asn Ala Arg Asp 
305                 310                 315                 320 


Gly Ile Pro Met Asp Asp Ile Pro Pro Leu Arg Thr Ser Val 
                325                 330                 


<210>  5967
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  5967

Met Ala Glu Leu Val Pro Phe Ala Val Pro Ile Glu Ser Asp Lys Thr 
1               5                   10                  15      


Leu Leu Val Trp Glu Leu Ser Ser Gly Pro Thr Ala Glu Ala Leu His 
            20                  25                  30          


His Ser Leu Phe Thr Ala Phe Ser Gln Phe Gly Leu Leu Tyr Ser Val 
        35                  40                  45              


Arg Val Phe Pro Asn Ala Ala Val Ala His Pro Gly Phe Tyr Ala Val 
    50                  55                  60                  


Ile Lys Phe Tyr Ser Ala Arg Ala Ala His Arg Ala Gln Lys Ala Cys 
65                  70                  75                  80  


Asp Arg Lys Gln Leu Phe Gln Lys Ser Pro Val Lys Val Arg Leu Gly 
                85                  90                  95      


Thr Arg His Lys Ala Val Gln His Gln Ala Leu Ala Leu Asn Ser Ser 
            100                 105                 110         


Lys Cys Gln Glu Leu Ala Asn Tyr Tyr Phe Gly Phe Asn Gly Cys Ser 
        115                 120                 125             


Lys Arg Ile Ile Lys Leu Gln Glu Leu Ser Asp Leu Glu Glu Arg Glu 
    130                 135                 140                 


Asn Glu Asp Ser Met Val Pro Leu Pro Lys Gln Ser Leu Lys Phe Phe 
145                 150                 155                 160 


Cys Ala Leu Glu Val Val Leu Pro Ser Cys Asp Cys Arg Ser Pro Gly 
                165                 170                 175     


Ile Gly Leu Val Glu Glu Pro Met Asp Lys Val Glu Glu Gly Pro Leu 
            180                 185                 190         


Ser Phe Leu Met Lys Arg Lys Thr Ala Gln Lys Leu Ala Ile Gln Lys 
        195                 200                 205             


Ala Leu Ser Asp Ala Phe Gln Lys Leu Leu Ile Val Val Leu Glu Ser 
    210                 215                 220                 


Gly Lys Ile Ala Val Glu Tyr Arg Pro Ser Glu Asp Ile Val Gly Val 
225                 230                 235                 240 


Arg Cys Glu Glu Glu Leu His Gly Leu Ile Gln Val Pro Cys Ser Pro 
                245                 250                 255     


Trp Lys Gln Tyr Gly Gln Glu Glu Glu Gly Tyr Leu Ser Asp Phe Ser 
            260                 265                 270         


Leu Glu Glu Glu Glu Phe Arg Leu Pro Glu Leu Asp 
        275                 280                 


<210>  5968
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  5968

Met Asn Phe Trp Arg Tyr Cys Phe Phe Ala Phe Thr Leu Leu Ser Val 
1               5                   10                  15      


Val Ile Phe Val Arg Phe Tyr Ser Ser Gln Leu Ser Pro Pro Lys Ser 
            20                  25                  30          


Tyr Glu Lys Leu Asn Ser Ser Ser Glu Arg Tyr Phe Arg Lys Thr Ala 
        35                  40                  45              


Cys Asn His Ala Leu Glu Lys Met Pro Val Phe Leu Trp Glu Asn Ile 
    50                  55                  60                  


Leu Pro Ser Pro Leu Arg Ser Val Pro Cys Lys Asp Tyr Leu Thr Gln 
65                  70                  75                  80  


Asn His Tyr Ile Thr Ser Pro Leu Ser Glu Glu Glu Ala Ala Phe Pro 
                85                  90                  95      


Leu Ala Tyr Val Met Val Ile His Lys Asp Phe Asp Thr Phe Glu Arg 
            100                 105                 110         


Leu Phe Arg Ala Ile Tyr Met Pro Gln Asn Val Tyr Cys Val His Val 
        115                 120                 125             


Asp Glu Lys Ala Pro Ala Glu Tyr Lys Glu Ser Val Arg Gln Leu Leu 
    130                 135                 140                 


Ser Cys Phe Gln Asn Ala Phe Ile Ala Ser Lys Thr Glu Ser Val Val 
145                 150                 155                 160 


Tyr Ala Gly Ile Ser Arg Leu Gln Ala Asp Leu Asn Cys Leu Lys Asp 
                165                 170                 175     


Leu Val Ala Ser Glu Val Pro Trp Lys Tyr Val Ile Asn Thr Cys Gly 
            180                 185                 190         


Gln Asp Phe Pro Leu Lys Thr Asn Arg Glu Ile Val Gln His Leu Lys 
        195                 200                 205             


Gly Phe Lys Gly Lys Asn Ile Thr Pro Gly Val Leu Pro Pro Asp His 
    210                 215                 220                 


Ala Ile Lys Arg Thr Lys Tyr Val His Gln Glu His Thr Asp Lys Gly 
225                 230                 235                 240 


Gly Phe Phe Val Lys Asn Thr Asn Ile Leu Lys Thr Ser Pro Pro His 
                245                 250                 255     


Gln Leu Thr Ile Tyr Phe Gly Thr Ala Tyr Val Ala Leu Thr Arg Asp 
            260                 265                 270         


Phe Val Asp Phe Val Leu Arg Asp Gln Arg Ala Ile Asp Leu Leu Gln 
        275                 280                 285             


Trp Ser Lys Asp Thr Tyr Ser Pro Asp Glu His Phe Trp Val Thr Leu 
    290                 295                 300                 


Asn Arg Val Ser Gly Val Pro Gly Ser Met Pro Asn Ala Ser Trp Thr 
305                 310                 315                 320 


Gly Asn Leu Arg Ala Ile Lys Trp Ser Asp Met Glu Asp Arg His Gly 
                325                 330                 335     


Gly Cys His Gly His Tyr Val His Gly Ile Cys Ile Tyr Gly Asn Gly 
            340                 345                 350         


Asp Leu Lys Trp Leu Val Asn Ser Pro Ser Leu Phe Ala Asn Lys Phe 
        355                 360                 365             


Glu Leu Asn Thr Tyr Pro Leu Thr Val Glu Cys Leu Glu Leu Arg His 
    370                 375                 380                 


Arg Glu Arg Thr Leu Asn Gln Ser Glu Thr Ala Ile Gln Pro Ser Trp 
385                 390                 395                 400 


Tyr Phe 
        


<210>  5969
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  5969

Met Gly Gln Thr Ala Gly Asp Leu Gly Trp Arg Leu Ser Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Leu Leu Val Gln Ala Gly Val Trp Gly Phe Pro Arg Pro 
            20                  25                  30          


Pro Gly Arg Pro Gln Leu Ser Leu Gln Glu Leu Arg Arg Glu Phe Thr 
        35                  40                  45              


Val Ser Leu His Leu Ala Arg Lys Leu Leu Ser Glu Val Arg Gly Gln 
    50                  55                  60                  


Ala His Arg Phe Ala Glu Ser His Leu Pro Gly Val Asn Leu Tyr Leu 
65                  70                  75                  80  


Leu Pro Leu Gly Glu Gln Leu Pro Asp Val Ser Leu Thr Phe Gln Ala 
                85                  90                  95      


Trp Arg Arg Leu Ser Asp Pro Glu Arg Leu Cys Phe Ile Ser Thr Thr 
            100                 105                 110         


Leu Gln Pro Phe His Ala Leu Leu Gly Gly Leu Gly Thr Gln Gly Arg 
        115                 120                 125             


Trp Thr Asn Met Glu Arg Met Gln Leu Trp Ala Met Arg Leu Asp Leu 
    130                 135                 140                 


Arg Asp Leu Gln Arg His Leu Arg Phe Gln Val Leu Ala Ala Gly Phe 
145                 150                 155                 160 


Asn Leu Pro Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
                165                 170                 175     


Arg Lys Gly Leu Leu Pro Gly Ala Leu Gly Ser Ala Leu Gln Gly Pro 
            180                 185                 190         


Ala Gln Val Ser Trp Pro Gln Leu Leu Ser Thr Tyr Arg Leu Leu His 
        195                 200                 205             


Ser Leu Glu Leu Val Leu Ser Arg Ala Val Arg Glu Leu Leu Leu Leu 
    210                 215                 220                 


Ser Lys Ala Gly His Ser Val Trp Pro Leu Gly Phe Pro Thr Leu Ser 
225                 230                 235                 240 


Pro Gln Pro 
            


<210>  5970
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  5970

Met Glu Gly Ala Ala Leu Leu Lys Ile Phe Val Val Cys Ile Trp Val 
1               5                   10                  15      


Gln Gln Asn His Pro Gly Trp Thr Val Ala Gly Gln Phe Gln Glu Lys 
            20                  25                  30          


Lys Arg Phe Thr Glu Glu Val Ile Glu Tyr Phe Gln Lys Lys Val Ser 
        35                  40                  45              


Pro Val His Leu Lys Ile Leu Leu Thr Ser Asp Glu Ala Trp Lys Arg 
    50                  55                  60                  


Phe Val Arg Val Ala Glu Leu Pro Arg Glu Glu Ala Asp Ala Leu Tyr 
65                  70                  75                  80  


Glu Ala Leu Lys Asn Leu Thr Pro Tyr Val Ala Ile Glu Asp Lys Asp 
                85                  90                  95      


Met Gln Gln Lys Glu Gln Gln Phe Arg Glu Trp Phe Leu Lys Glu Phe 
            100                 105                 110         


Pro Gln Ile Arg Trp Lys Ile Gln Glu Ser Ile Glu Arg Leu Arg Val 
        115                 120                 125             


Ile Ala Asn Glu Ile Glu Lys Val His Arg Gly Cys Val Ile Ala Asn 
    130                 135                 140                 


Val Val Ser Gly Ser Thr Gly Ile Leu Ser Val Ile Gly Val Met Leu 
145                 150                 155                 160 


Ala Pro Phe Thr Ala Gly Leu Ser Leu Ser Ile Thr Ala Ala Gly Val 
                165                 170                 175     


Gly Leu Gly Ile Ala Ser Ala Thr Ala Gly Ile Ala Ser Ser Ile Val 
            180                 185                 190         


Glu Asn Thr Tyr Thr Arg Ser Ala Glu Leu Thr Ala Ser Arg Leu Thr 
        195                 200                 205             


Ala Thr Ser Thr Asp Gln Leu Glu Ala Leu Arg Asp Ile Leu Arg Asp 
    210                 215                 220                 


Ile Thr Pro Asn Val Leu Ser Phe Ala Leu Asp Phe Asp Glu Ala Thr 
225                 230                 235                 240 


Lys Met Ile Ala Asn Asp Val His Thr Leu Arg Arg Ser Lys Ala Thr 
                245                 250                 255     


Val Gly Arg Pro Leu Ile Ala Trp Arg Tyr Val Pro Ile Asn Val Val 
            260                 265                 270         


Glu Thr Leu Arg Thr Arg Gly Ala Pro Thr Arg Ile Val Arg Lys Val 
        275                 280                 285             


Ala Arg Asn Leu Gly Lys Ala Thr Ser Gly Val Leu Val Val Leu Asp 
    290                 295                 300                 


Val Val Asn Leu Val Gln Asp Ser Leu Asp Leu His Lys Gly Ala Lys 
305                 310                 315                 320 


Ser Glu Ser Ala Glu Ser Leu Arg Gln Trp Ala Gln Glu Leu Glu Glu 
                325                 330                 335     


Asn Leu Asn Glu Leu Thr His Ile His Gln Ser Leu Lys Ala Gly 
            340                 345                 350     


<210>  5971
<211>  525
<212>  PRT
<213>  Homo sapiens

<400>  5971

Met Leu Phe Leu Ser Phe His Ala Gly Ser Trp Glu Ser Trp Cys Cys 
1               5                   10                  15      


Cys Cys Leu Ile Pro Ala Asp Arg Pro Trp Asp Arg Gly Gln His Trp 
            20                  25                  30          


Gln Leu Glu Met Ala Asp Thr Arg Ser Val His Glu Thr Arg Phe Glu 
        35                  40                  45              


Ala Ala Val Lys Val Ile Gln Ser Leu Pro Lys Asn Gly Ser Phe Gln 
    50                  55                  60                  


Pro Thr Asn Glu Met Met Leu Lys Phe Tyr Ser Phe Tyr Lys Gln Ala 
65                  70                  75                  80  


Thr Glu Gly Pro Cys Lys Leu Ser Arg Pro Gly Phe Trp Asp Pro Ile 
                85                  90                  95      


Gly Arg Tyr Lys Trp Asp Ala Trp Ser Ser Leu Gly Asp Met Thr Lys 
            100                 105                 110         


Glu Glu Ala Met Ile Ala Tyr Val Glu Glu Met Lys Lys Ile Ile Glu 
        115                 120                 125             


Thr Met Pro Met Thr Glu Lys Val Glu Glu Leu Leu Arg Val Ile Gly 
    130                 135                 140                 


Pro Phe Tyr Glu Ile Val Glu Asp Lys Lys Ser Gly Arg Ser Ser Asp 
145                 150                 155                 160 


Ile Thr Ser Asp Leu Gly Asn Val Leu Thr Ser Thr Pro Asn Ala Lys 
                165                 170                 175     


Thr Val Asn Gly Lys Ala Glu Ser Ser Asp Ser Gly Ala Glu Ser Glu 
            180                 185                 190         


Glu Glu Glu Ala Gln Glu Glu Val Lys Gly Ala Glu Gln Ser Asp Asn 
        195                 200                 205             


Asp Lys Lys Met Met Lys Lys Ser Ala Asp His Lys Asn Leu Glu Val 
    210                 215                 220                 


Ile Val Thr Asn Gly Tyr Asp Lys Asp Gly Phe Val Gln Asp Ile Gln 
225                 230                 235                 240 


Asn Asp Ile His Ala Ser Ser Ser Leu Asn Gly Arg Ser Thr Glu Glu 
                245                 250                 255     


Val Lys Pro Ile Asp Glu Asn Leu Gly Gln Thr Gly Lys Ser Ala Val 
            260                 265                 270         


Cys Ile His Gln Asp Ile Asn Asp Asp His Val Glu Asp Val Thr Gly 
        275                 280                 285             


Ile Gln His Leu Thr Ser Asp Ser Asp Ser Glu Val Tyr Cys Asp Ser 
    290                 295                 300                 


Met Glu Gln Phe Gly Gln Glu Glu Ser Leu Asp Ser Phe Thr Ser Asn 
305                 310                 315                 320 


Asn Gly Pro Phe Gln Tyr Tyr Leu Gly Gly His Ser Ser Gln Pro Met 
                325                 330                 335     


Glu Asn Ser Gly Phe Arg Glu Asp Ile Gln Val Pro Pro Gly Asn Gly 
            340                 345                 350         


Asn Ile Gly Asn Met Gln Val Val Ala Val Glu Gly Lys Gly Glu Val 
        355                 360                 365             


Lys His Gly Gly Glu Asp Gly Arg Asn Asn Ser Gly Ala Pro His Arg 
    370                 375                 380                 


Glu Lys Arg Gly Gly Glu Thr Asp Glu Phe Ser Asn Val Arg Arg Gly 
385                 390                 395                 400 


Arg Gly His Arg Met Gln His Leu Ser Glu Gly Thr Lys Gly Arg Gln 
                405                 410                 415     


Val Gly Ser Gly Gly Asp Gly Glu Arg Trp Gly Ser Asp Arg Gly Ser 
            420                 425                 430         


Arg Gly Ser Leu Asn Glu Gln Ile Ala Leu Val Leu Met Arg Leu Gln 
        435                 440                 445             


Glu Asp Met Gln Asn Val Leu Gln Arg Leu Gln Lys Leu Glu Thr Leu 
    450                 455                 460                 


Thr Ala Leu Gln Ala Lys Ser Ser Thr Ser Thr Leu Gln Thr Ala Pro 
465                 470                 475                 480 


Gln Pro Thr Ser Gln Arg Pro Ser Trp Trp Pro Phe Glu Met Ser Pro 
                485                 490                 495     


Gly Val Leu Thr Phe Ala Ile Ile Trp Pro Phe Ile Ala Gln Trp Leu 
            500                 505                 510         


Val Tyr Leu Tyr Tyr Gln Arg Arg Arg Arg Lys Leu Asn 
        515                 520                 525 


<210>  5972
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  5972

Met Glu Gly Gly Ala Tyr Gly Ala Gly Lys Ala Gly Gly Ala Phe Asp 
1               5                   10                  15      


Pro Tyr Thr Leu Val Arg Gln Pro His Thr Ile Leu Arg Val Val Ser 
            20                  25                  30          


Trp Leu Phe Ser Ile Val Val Phe Gly Ser Ile Val Asn Glu Gly Tyr 
        35                  40                  45              


Leu Asn Ser Ala Ser Glu Gly Glu Glu Phe Cys Ile Tyr Asn Arg Asn 
    50                  55                  60                  


Pro Asn Ala Cys Ser Tyr Gly Val Ala Val Gly Val Leu Ala Phe Leu 
65                  70                  75                  80  


Thr Cys Leu Leu Tyr Leu Ala Leu Asp Val Tyr Phe Pro Gln Ile Ser 
                85                  90                  95      


Ser Val Lys Asp Arg Lys Lys Ala Val Leu Ser Asp Ile Gly Val Ser 
            100                 105                 110         


Ala Phe Trp Ala Phe Leu Trp Phe Val Gly Phe Cys Tyr Leu Ala Asn 
        115                 120                 125             


Gln Trp Gln Val Ser Lys Pro Lys Asp Asn Pro Leu Asn Glu Gly Thr 
    130                 135                 140                 


Asp Ala Ala Arg Ala Ala Ile Ala Phe Ser Phe Phe Ser Ile Phe Thr 
145                 150                 155                 160 


Trp Ser Leu Thr Ala Ala Leu Ala Val Arg Arg Phe Lys Asp Leu Ser 
                165                 170                 175     


Phe Gln Glu Glu Tyr Ser Thr Leu Phe Pro Ala Ser Ala Gln Pro 
            180                 185                 190     


<210>  5973
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  5973

Met Leu Thr Leu Glu Phe Gly Ile Leu Glu Phe Asp Pro Ser Trp Ile 
1               5                   10                  15      


Gly Ser Trp Thr Gln Arg Ser Trp Val Ser Trp Arg Ser Arg Pro Gly 
            20                  25                  30          


Cys Glu Leu Phe Ser Ile Val Val Phe Gly Ser Ile Val Asn Glu Gly 
        35                  40                  45              


Tyr Leu Asn Ser Ala Ser Glu Gly Glu Glu Phe Cys Ile Tyr Asn Arg 
    50                  55                  60                  


Asn Pro Asn Ala Cys Ser Tyr Gly Val Ala Val Gly Val Leu Ala Phe 
65                  70                  75                  80  


Leu Thr Cys Leu Leu Tyr Leu Ala Leu Asp Val Tyr Phe Pro Gln Ile 
                85                  90                  95      


Ser Ser Val Lys Asp Arg Lys Lys Ala Val Leu Ser Asp Ile Gly Val 
            100                 105                 110         


Ser Ala Phe Trp Ala Phe Leu Trp Phe Val Gly Phe Cys Tyr Leu Ala 
        115                 120                 125             


Asn Gln Trp Gln Val Ser Lys Pro Lys Asp Asn Pro Leu Asn Glu Gly 
    130                 135                 140                 


Thr Asp Ala Ala Arg Ala Ala Ile Ala Phe Ser Phe Phe Ser Ile Phe 
145                 150                 155                 160 


Thr Trp Ser Leu Thr Ala Ala Leu Ala Val Arg Arg Phe Lys Asp Leu 
                165                 170                 175     


Ser Phe Gln Glu Glu Tyr Ser Thr Leu Phe Pro Ala Ser Ala Gln Pro 
            180                 185                 190         


<210>  5974
<211>  1210
<212>  PRT
<213>  Homo sapiens

<400>  5974

Met Glu Glu His Ser Tyr Ile Gln Lys Glu Leu Asp Leu Gln Asn Gly 
1               5                   10                  15      


Ser Leu Glu Glu Asp Ser Val Val His Ser Val Glu Asn Asp Ser Gln 
            20                  25                  30          


Asn Met Met Glu Ser Leu Ser Pro Lys Lys Tyr Ser Ser Ser Leu Arg 
        35                  40                  45              


Phe Lys Ala Asn Gly Asp Tyr Ser Gly Ser Tyr Leu Thr Leu Ser Gln 
    50                  55                  60                  


Pro Val Pro Ala Lys Arg Ser Pro Ser Pro Leu Gly Thr Ser Val Arg 
65                  70                  75                  80  


Ser Ser Pro Ser Leu Ala Lys Ile Gln Gly Ser Lys Gln Phe Ser Tyr 
                85                  90                  95      


Asp Gly Thr Asp Lys Asn Ile Pro Met Lys Pro Pro Thr Pro Leu Leu 
            100                 105                 110         


Asn Thr Thr Ser Ser Leu Ser Gly Tyr Pro Leu Gly Arg Ala Asp Phe 
        115                 120                 125             


Asp His Tyr Thr Gly Arg Asp Ser Glu Arg Ala Leu Arg Leu Ser Glu 
    130                 135                 140                 


Lys Pro Pro Tyr Ser Lys Tyr Ser Ser Arg His Lys Ser His Asp Asn 
145                 150                 155                 160 


Val Tyr Ser Leu Gly Gly Leu Glu Gly Arg Lys Ala Ser Gly Ser Leu 
                165                 170                 175     


Leu Ala Met Trp Asn Gly Ser Ser Leu Ser Asp Ala Gly Pro Pro Pro 
            180                 185                 190         


Ile Ser Arg Ser Gly Ala Ala Ser Met Pro Ser Ser Pro Lys Gln Ala 
        195                 200                 205             


Arg Lys Met Ser Ile Gln Asp Ser Leu Ala Leu Gln Pro Lys Leu Thr 
    210                 215                 220                 


Arg His Lys Glu Leu Ala Ser Glu Asn Ile Asn Leu Arg Thr Arg Lys 
225                 230                 235                 240 


Tyr Ser Ser Ser Ser Leu Ser His Met Gly Ala Tyr Ser Arg Ser Leu 
                245                 250                 255     


Pro Arg Leu Tyr Arg Ala Thr Glu Asn Gln Leu Thr Pro Leu Ser Leu 
            260                 265                 270         


Pro Pro Arg Asn Ser Leu Gly Asn Ser Lys Arg Thr Lys Leu Gly Glu 
        275                 280                 285             


Lys Asp Leu Pro His Ser Val Ile Asp Asn Asp Asn Tyr Leu Asn Phe 
    290                 295                 300                 


Ser Ser Leu Ser Ser Gly Ala Leu Pro Tyr Lys Thr Ser Ala Ser Glu 
305                 310                 315                 320 


Gly Asn Pro Tyr Val Ser Ser Thr Leu Ser Val Pro Ala Ser Pro Arg 
                325                 330                 335     


Val Ala Arg Lys Met Leu Leu Ala Ser Thr Ser Ser Cys Ala Ser Asp 
            340                 345                 350         


Asp Phe Asp Gln Ala Ser Tyr Val Gly Thr Asn Pro Ser His Ser Leu 
        355                 360                 365             


Leu Ala Gly Glu Ser Asp Arg Val Phe Ala Thr Arg Arg Asn Phe Ser 
    370                 375                 380                 


Cys Gly Ser Val Glu Phe Asp Glu Ala Asp Leu Glu Ser Leu Arg Gln 
385                 390                 395                 400 


Ala Ser Gly Thr Pro Gln Pro Ala Leu Arg Glu Arg Lys Ser Ser Ile 
                405                 410                 415     


Ser Ser Ile Ser Gly Arg Asp Asp Leu Met Asp Tyr His Arg Arg Gln 
            420                 425                 430         


Arg Glu Glu Arg Leu Arg Glu Gln Glu Met Glu Arg Leu Glu Arg Gln 
        435                 440                 445             


Arg Leu Glu Thr Ile Leu Ser Leu Cys Ala Glu Tyr Thr Lys Pro Asp 
    450                 455                 460                 


Ser Arg Leu Ser Thr Gly Thr Thr Val Glu Asp Val Gln Lys Ile Asn 
465                 470                 475                 480 


Lys Glu Leu Glu Lys Leu Gln Leu Ser Asp Glu Glu Ser Val Phe Glu 
                485                 490                 495     


Glu Ala Leu Met Ser Pro Asp Thr Arg Tyr Arg Cys His Arg Lys Asp 
            500                 505                 510         


Ser Leu Pro Asp Ala Asp Leu Ala Ser Cys Gly Ser Leu Ser Gln Ser 
        515                 520                 525             


Ser Ala Ser Phe Phe Thr Pro Arg Ser Thr Arg Asn Asp Glu Leu Leu 
    530                 535                 540                 


Ser Asp Leu Thr Arg Thr Pro Pro Pro Pro Ser Ser Thr Phe Pro Lys 
545                 550                 555                 560 


Ala Ser Ser Glu Ser Ser Tyr Leu Ser Ile Leu Pro Lys Thr Pro Glu 
                565                 570                 575     


Gly Ile Ser Glu Glu Gln Arg Ser Gln Glu Leu Ala Ala Met Glu Glu 
            580                 585                 590         


Thr Arg Ile Val Ile Leu Asn Asn Leu Glu Glu Leu Lys Gln Lys Ile 
        595                 600                 605             


Lys Asp Ile Asn Asp Gln Met Asp Glu Ser Phe Arg Glu Leu Asp Met 
    610                 615                 620                 


Glu Cys Ala Leu Leu Asp Gly Glu Gln Lys Ser Glu Thr Thr Glu Leu 
625                 630                 635                 640 


Met Lys Glu Lys Glu Ile Leu Asp His Leu Asn Arg Lys Ile Ala Glu 
                645                 650                 655     


Leu Glu Lys Asn Ile Val Gly Glu Lys Thr Lys Asp Ala Asp Leu Leu 
            660                 665                 670         


Asp Val Glu Ser Lys His Phe Glu Asp Leu Glu Phe Gln Gln Leu Glu 
        675                 680                 685             


His Glu Ser Arg Leu Asp Glu Glu Lys Glu Asn Leu Thr Gln Gln Leu 
    690                 695                 700                 


Leu Arg Glu Val Ala Glu Tyr Gln Arg Asn Ile Val Ser Arg Lys Glu 
705                 710                 715                 720 


Lys Ile Ser Ala Leu Lys Lys Gln Ala Asn His Ile Val Gln Gln Ala 
                725                 730                 735     


Gln Arg Glu Gln Asp His Phe Val Lys Glu Lys Asn Asn Leu Ile Met 
            740                 745                 750         


Met Leu Gln Arg Glu Lys Glu Asn Leu Cys Asn Leu Glu Lys Lys Tyr 
        755                 760                 765             


Ser Ser Leu Ser Gly Gly Lys Gly Phe Pro Val Asn Pro Asn Thr Leu 
    770                 775                 780                 


Lys Glu Gly Tyr Ile Ser Val Asn Glu Ile Asn Glu Pro Cys Gly Asn 
785                 790                 795                 800 


Ser Thr Asn Leu Ser Pro Ser Thr Gln Phe Pro Ala Asp Ala Asp Ala 
                805                 810                 815     


Val Ala Thr Glu Pro Ala Thr Ala Val Leu Ala Ser Gln Pro Gln Ser 
            820                 825                 830         


Lys Glu His Phe Arg Ser Leu Glu Glu Arg Lys Lys Gln His Lys Glu 
        835                 840                 845             


Gly Leu Tyr Leu Ser Asp Thr Leu Pro Arg Lys Lys Thr Thr Ser Ser 
    850                 855                 860                 


Ile Ser Pro His Phe Ser Ser Ala Thr Met Gly Arg Ser Ile Thr Pro 
865                 870                 875                 880 


Lys Ala His Leu Pro Leu Gly Gln Ser Asn Ser Cys Gly Ser Val Leu 
                885                 890                 895     


Pro Pro Ser Leu Ala Ala Met Ala Lys Asp Ser Glu Ser Arg Arg Met 
            900                 905                 910         


Leu Arg Gly Tyr Asn His Gln Gln Met Ser Glu Gly His Arg Gln Lys 
        915                 920                 925             


Ser Glu Phe Tyr Asn Arg Thr Ala Ser Glu Ser Asn Val Tyr Leu Asn 
    930                 935                 940                 


Ser Phe His Tyr Pro Asp His Ser Tyr Lys Asp Gln Ala Phe Asp Thr 
945                 950                 955                 960 


Leu Ser Leu Asp Ser Ser Asp Ser Met Glu Thr Ser Ile Ser Ala Cys 
                965                 970                 975     


Ser Pro Asp Asn Ile Ser Ser Ala Ser Thr Ser Asn Ile Ala Arg Ile 
            980                 985                 990         


Glu Glu Met Glu Arg Leu Leu Lys  Gln Ala His Ala Glu  Lys Thr Arg 
        995                 1000                 1005             


Leu Leu  Glu Ser Arg Glu Arg  Glu Met Glu Ala Lys  Lys Arg Ala 
    1010                 1015                 1020             


Leu Glu  Glu Glu Lys Arg Arg  Arg Glu Ile Leu Glu  Lys Arg Leu 
    1025                 1030                 1035             


Gln Glu  Glu Thr Ser Gln Arg  Gln Lys Leu Ile Glu  Lys Glu Val 
    1040                 1045                 1050             


Lys Ile  Arg Glu Arg Gln Arg  Ala Gln Ala Arg Pro  Leu Thr Arg 
    1055                 1060                 1065             


Tyr Leu  Pro Val Arg Lys Glu  Asp Phe Asp Leu Arg  Ser His Val 
    1070                 1075                 1080             


Glu Thr  Ala Gly His Asn Ile  Asp Thr Cys Tyr His  Val Ser Ile 
    1085                 1090                 1095             


Thr Glu  Lys Thr Cys Arg Gly  Phe Leu Ile Lys Met  Gly Gly Lys 
    1100                 1105                 1110             


Ile Lys  Thr Trp Lys Lys Arg  Trp Phe Val Phe Asp  Arg Asn Lys 
    1115                 1120                 1125             


Arg Thr  Phe Ser Tyr Tyr Ala  Asp Lys His Glu Thr  Lys Leu Lys 
    1130                 1135                 1140             


Gly Val  Ile Tyr Phe Gln Ala  Ile Glu Glu Val Tyr  Tyr Asp His 
    1145                 1150                 1155             


Leu Lys  Asn Ala Asn Lys Ser  Pro Asn Pro Leu Leu  Thr Phe Ser 
    1160                 1165                 1170             


Val Lys  Thr His Asp Arg Ile  Tyr Tyr Met Val Ala  Pro Ser Pro 
    1175                 1180                 1185             


Glu Ala  Met Arg Ile Trp Met  Asp Val Ile Val Thr  Gly Ala Glu 
    1190                 1195                 1200             


Gly Tyr  Thr His Phe Leu Leu  
    1205                 1210 


<210>  5975
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  5975

Met Val Asp Leu Thr Gln Val Met Asp Asp Glu Val Phe Met Ala Phe 
1               5                   10                  15      


Ala Ser Tyr Ala Thr Ile Ile Leu Ser Lys Met Met Leu Met Ser Thr 
            20                  25                  30          


Ala Thr Ala Phe Tyr Arg Leu Thr Arg Lys Val Phe Ala Asn Pro Glu 
        35                  40                  45              


Asp Cys Val Ala Phe Gly Lys Gly Glu Asn Ala Lys Lys Tyr Leu Arg 
    50                  55                  60                  


Thr Asp Asp Arg Val Glu Arg Val Arg Arg Ala His Leu Asn Asp Leu 
65                  70                  75                  80  


Glu Asn Ile Ile Pro Phe Leu Gly Ile Gly Leu Leu Tyr Ser Leu Ser 
                85                  90                  95      


Gly Pro Asp Pro Ser Thr Ala Ile Leu His Phe Arg Leu Phe Val Gly 
            100                 105                 110         


Ala Arg Ile Tyr His Thr Ile Ala Tyr Leu Thr Pro Leu Pro Gln Pro 
        115                 120                 125             


Asn Arg Ala Leu Ser Phe Phe Val Gly Tyr Gly Val Thr Leu Ser Met 
    130                 135                 140                 


Ala Tyr Arg Leu Leu Lys Ser Lys Leu Tyr Leu 
145                 150                 155 


<210>  5976
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  5976

Met Val Asp Leu Thr Gln Val Met Asp Asp Glu Val Phe Met Ala Phe 
1               5                   10                  15      


Ala Ser Tyr Ala Thr Ile Ile Leu Ser Lys Met Met Leu Met Ser Thr 
            20                  25                  30          


Ala Thr Ala Phe Tyr Arg Leu Thr Arg Lys Val Phe Ala Asn Pro Glu 
        35                  40                  45              


Asp Cys Val Ala Phe Gly Lys Gly Glu Asn Ala Lys Lys Tyr Leu Arg 
    50                  55                  60                  


Thr Asp Asp Arg Val Glu Arg Val Arg Arg Ala His Leu Asn Asp Leu 
65                  70                  75                  80  


Glu Asn Ile Ile Pro Phe Leu Gly Ile Gly Leu Leu Tyr Ser Leu Ser 
                85                  90                  95      


Gly Pro Asp Pro Ser Thr Ala Ile Leu His Phe Arg Leu Phe Val Gly 
            100                 105                 110         


Ala Arg Ile Tyr His Thr Ile Ala Tyr Leu Thr Pro Leu Pro Gln Pro 
        115                 120                 125             


Asn Arg Ala Leu Ser Phe Phe Val Gly Tyr Gly Val Thr Leu Ser Met 
    130                 135                 140                 


Ala Tyr Arg Leu Leu Lys Ser Lys Leu Tyr Leu 
145                 150                 155 


<210>  5977
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  5977

Met Val Asp Leu Thr Gln Val Met Asp Asp Glu Val Phe Met Ala Phe 
1               5                   10                  15      


Ala Ser Tyr Ala Thr Ile Ile Leu Ser Lys Met Met Leu Met Ser Thr 
            20                  25                  30          


Ala Thr Ala Phe Tyr Arg Leu Thr Arg Lys Val Phe Ala Asn Pro Glu 
        35                  40                  45              


Asp Cys Val Ala Phe Gly Lys Gly Glu Asn Ala Lys Lys Tyr Leu Arg 
    50                  55                  60                  


Thr Asp Asp Arg Val Glu Arg Val Arg Arg Ala His Leu Asn Asp Leu 
65                  70                  75                  80  


Glu Asn Ile Ile Pro Phe Leu Gly Ile Gly Leu Leu Tyr Ser Leu Ser 
                85                  90                  95      


Gly Pro Asp Pro Ser Thr Ala Ile Leu His Phe Arg Leu Phe Val Gly 
            100                 105                 110         


Ala Arg Ile Tyr His Thr Ile Ala Tyr Leu Thr Pro Leu Pro Gln Pro 
        115                 120                 125             


Asn Arg Ala Leu Ser Phe Phe Val Gly Tyr Gly Val Thr Leu Ser Met 
    130                 135                 140                 


Ala Tyr Arg Leu Leu Lys Ser Lys Leu Tyr Leu 
145                 150                 155 


<210>  5978
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  5978

Met Ser Ala Cys Gly Arg Lys Ala Leu Thr Leu Leu Ser Ser Val Phe 
1               5                   10                  15      


Ala Val Cys Gly Leu Gly Leu Leu Gly Ile Ala Val Ser Thr Asp Tyr 
            20                  25                  30          


Trp Leu Tyr Leu Glu Glu Gly Val Ile Val Pro Gln Asn Gln Ser Thr 
        35                  40                  45              


Glu Ile Lys Met Ser Leu His Ser Gly Leu Trp Arg Val Cys Phe Leu 
    50                  55                  60                  


Ala Gly Glu Glu Arg Gly Arg Cys Phe Thr Ile Glu Tyr Val Met Pro 
65                  70                  75                  80  


Met Asn Thr Gln Leu Thr Ser Glu Ser Thr Val Asn Val Leu Lys Met 
                85                  90                  95      


Ile Arg Ser Ala Thr Pro Phe Pro Leu Val Ser Leu Phe Phe Met Phe 
            100                 105                 110         


Ile Gly Phe Ile Leu Asn Asn Ile Gly His Ile Arg Pro His Arg Thr 
        115                 120                 125             


Ile Leu Ala Phe Val Ser Gly Ile Phe Phe Ile Leu Ser Gly Leu Ser 
    130                 135                 140                 


Leu Val Val Gly Leu Val Leu Tyr Ile Ser Ser Ile Asn Asp Glu Met 
145                 150                 155                 160 


Leu Asn Arg Thr Lys Asp Ala Glu Thr Tyr Phe Asn Tyr Lys Tyr Gly 
                165                 170                 175     


Trp Ser Phe Ala Phe Ala Ala Ile Ser Phe Leu Leu Thr Glu Ser Ala 
            180                 185                 190         


Gly Val Met Ser Val Tyr Leu Phe Met Lys Arg Tyr Thr Ala Glu Asp 
        195                 200                 205             


Met Tyr Arg Pro His Pro Gly Phe Tyr Arg Pro Arg Leu Ser Asn Cys 
    210                 215                 220                 


Ser Asp Tyr Ser Gly Gln Phe Leu His Pro Asp Ala Trp Val Arg Gly 
225                 230                 235                 240 


Arg Ser Pro Ser Asp Ile Ser Ser Glu Ala Ser Leu Gln Met Asn Ser 
                245                 250                 255     


Asn Tyr Pro Ala Leu Leu Lys Cys Pro Asp Tyr Asp Gln Met Ser Ser 
            260                 265                 270         


Ser Pro Cys 
        275 


<210>  5979
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  5979

Met Glu Thr Arg Pro Arg Leu Gly Ala Thr Cys Leu Leu Gly Phe Ser 
1               5                   10                  15      


Phe Leu Leu Leu Val Ile Ser Ser Asp Gly His Asn Gly Leu Gly Lys 
            20                  25                  30          


Gly Phe Gly Asp His Ile His Trp Arg Thr Leu Glu Asp Gly Lys Lys 
        35                  40                  45              


Glu Ala Ala Ala Ser Gly Leu Pro Leu Met Val Ile Ile His Lys Ser 
    50                  55                  60                  


Trp Cys Gly Ala Cys Lys Ala Leu Lys Pro Lys Phe Ala Glu Ser Thr 
65                  70                  75                  80  


Glu Ile Ser Glu Leu Ser His Asn Phe Val Met Val Asn Leu Glu Asp 
                85                  90                  95      


Glu Glu Glu Pro Lys Asp Glu Asp Phe Ser Pro Asp Gly Gly Tyr Ile 
            100                 105                 110         


Pro Arg Ile Leu Phe Leu Asp Pro Ser Gly Lys Val His Pro Glu Ile 
        115                 120                 125             


Ile Asn Glu Asn Gly Asn Pro Ser Tyr Lys Tyr Phe Tyr Val Ser Ala 
    130                 135                 140                 


Glu Gln Val Val Gln Gly Met Lys Glu Ala Gln Glu Arg Leu Thr Gly 
145                 150                 155                 160 


Asp Ala Phe Arg Lys Lys His Leu Glu Asp Glu Leu 
                165                 170         


<210>  5980
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  5980

Met Phe Arg Cys Gly Gly Leu Ala Ala Gly Ala Leu Lys Gln Lys Leu 
1               5                   10                  15      


Val Pro Leu Val Arg Thr Val Cys Val Arg Ser Pro Arg Gln Arg Asn 
            20                  25                  30          


Arg Leu Pro Val Val Gln Ser His His Leu Gly Ser Pro Ser Arg Ser 
        35                  40                  45              


Leu Ala Ser Thr Gly Ala Ser Gly Lys Asp Gly Ser Asn Leu Val Tyr 
    50                  55                  60                  


Phe Leu Ile Val Gly Ala Thr Val Thr Gly Ala Gly Val Tyr Tyr Ala 
65                  70                  75                  80  


Tyr Lys Thr Met Lys Glu Asp Glu Lys Arg Tyr Asn Glu Arg Ile Ser 
                85                  90                  95      


Gly Leu Gly Leu Thr Pro Glu Gln Lys Gln Lys Lys Ala Ala Leu Ser 
            100                 105                 110         


Ala Ser Glu Gly Glu Glu Val Pro Gln Asp Lys Ala Pro Ser His Val 
        115                 120                 125             


Pro Phe Leu Leu Ile Gly Gly Gly Thr Ala Ala Phe Ala Ala Ala Arg 
    130                 135                 140                 


Ser Ile Arg Ala Arg Asp Pro Gly Ala Arg Val Leu Ile Val Ser Glu 
145                 150                 155                 160 


Asp Pro Glu Leu Pro Tyr Met Arg Pro Pro Leu Ser Lys Glu Leu Trp 
                165                 170                 175     


Phe Ser Asp Asp Pro Asn Val Thr Lys Thr Leu Arg Phe Lys Gln Trp 
            180                 185                 190         


Asn Gly Lys Glu Arg Ser Ile Tyr Phe Gln Pro Pro Ser Phe Tyr Val 
        195                 200                 205             


Ser Ala Gln Asp Leu Pro His Ile Glu Asn Gly Gly Val Ala Val Leu 
    210                 215                 220                 


Thr Gly Lys Lys Val Val Gln Leu Asp Val Arg Asp Asn Met Val Lys 
225                 230                 235                 240 


Leu Asn Asp Gly Ser Gln Ile Thr Tyr Glu Lys Cys Leu Ile Ala Thr 
                245                 250                 255     


Gly Gly Thr Pro Arg Ser Leu Ser Ala Ile Asp Arg Ala Gly Ala Glu 
            260                 265                 270         


Val Lys Ser Arg Thr Thr Leu Phe Arg Lys Ile Gly Asp Phe Arg Ser 
        275                 280                 285             


Leu Glu Lys Ile Ser Arg Glu Val Lys Ser Ile Thr Ile Ile Gly Gly 
    290                 295                 300                 


Gly Phe Leu Gly Ser Glu Leu Ala Cys Ala Leu Gly Arg Lys Ala Arg 
305                 310                 315                 320 


Ala Leu Gly Thr Glu Val Ile Gln Leu Phe Pro Glu Lys Gly Asn Met 
                325                 330                 335     


Gly Lys Ile Leu Pro Glu Tyr Leu Ser Asn Trp Thr Met Glu Lys Val 
            340                 345                 350         


Arg Arg Glu Gly Val Lys Val Met Pro Asn Ala Ile Val Gln Ser Val 
        355                 360                 365             


Gly Val Ser Ser Gly Lys Leu Leu Ile Lys Leu Lys Asp Gly Arg Lys 
    370                 375                 380                 


Val Glu Thr Asp His Ile Val Ala Ala Val Gly Leu Glu Pro Asn Val 
385                 390                 395                 400 


Glu Leu Ala Lys Thr Gly Gly Leu Glu Ile Asp Ser Asp Phe Gly Gly 
                405                 410                 415     


Phe Arg Val Asn Ala Glu Leu Gln Ala Arg Ser Asn Ile Trp Val Ala 
            420                 425                 430         


Gly Asp Ala Ala Cys Phe Tyr Asp Ile Lys Leu Gly Arg Arg Arg Val 
        435                 440                 445             


Glu His His Asp His Ala Val Val Ser Gly Arg Leu Ala Gly Glu Asn 
    450                 455                 460                 


Met Thr Gly Ala Ala Lys Pro Tyr Trp His Gln Ser Met Phe Trp Ser 
465                 470                 475                 480 


Asp Leu Gly Pro Asp Val Gly Tyr Glu Ala Ile Gly Leu Val Asp Ser 
                485                 490                 495     


Ser Leu Pro Thr Val Gly Val Phe Ala Lys Ala Thr Ala Gln Asp Asn 
            500                 505                 510         


Pro Lys Ser Ala Thr Glu Gln Ser Gly Thr Gly Ile Arg Ser Glu Ser 
        515                 520                 525             


Glu Thr Glu Ser Glu Ala Ser Glu Ile Thr Ile Pro Pro Ser Thr Pro 
    530                 535                 540                 


Ala Val Pro Gln Ala Pro Val Gln Gly Glu Asp Tyr Gly Lys Gly Val 
545                 550                 555                 560 


Ile Phe Tyr Leu Arg Asp Lys Val Val Val Gly Ile Val Leu Trp Asn 
                565                 570                 575     


Ile Phe Asn Arg Met Pro Ile Ala Arg Lys Ile Ile Lys Asp Gly Glu 
            580                 585                 590         


Gln His Glu Asp Leu Asn Glu Val Ala Lys Leu Phe Asn Ile His Glu 
        595                 600                 605             


Asp 
    


<210>  5981
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  5981

Met Glu Thr Arg Pro Arg Leu Gly Ala Thr Cys Leu Leu Gly Phe Ser 
1               5                   10                  15      


Phe Leu Leu Leu Val Ile Ser Ser Asp Gly His Asn Gly Leu Gly Lys 
            20                  25                  30          


Gly Phe Gly Asp His Ile His Trp Arg Thr Leu Glu Asp Gly Lys Lys 
        35                  40                  45              


Glu Ala Ala Ala Ser Gly Leu Pro Leu Met Val Ile Ile His Lys Ser 
    50                  55                  60                  


Trp Cys Gly Ala Cys Lys Ala Leu Lys Pro Lys Phe Ala Glu Ser Thr 
65                  70                  75                  80  


Glu Ile Ser Glu Leu Ser His Asn Phe Val Met Val Asn Leu Glu Asp 
                85                  90                  95      


Glu Glu Glu Pro Lys Asp Glu Asp Phe Ser Pro Asp Gly Gly Tyr Ile 
            100                 105                 110         


Pro Arg Ile Leu Phe Leu Asp Pro Ser Gly Lys Val His Pro Glu Ile 
        115                 120                 125             


Ile Asn Glu Asn Gly Asn Pro Ser Tyr Lys Tyr Phe Tyr Val Ser Ala 
    130                 135                 140                 


Glu Gln Val Val Gln Gly Met Lys Glu Ala Gln Glu Arg Leu Thr Gly 
145                 150                 155                 160 


Asp Ala Phe Arg Lys Lys His Leu Glu Asp Glu Leu 
                165                 170         


<210>  5982
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  5982

Met Phe Arg Cys Gly Gly Leu Ala Ala Gly Ala Leu Lys Gln Lys Leu 
1               5                   10                  15      


Val Pro Leu Val Arg Thr Val Cys Val Arg Ser Pro Arg Gln Arg Asn 
            20                  25                  30          


Arg Leu Pro Val Val Gln Ser His His Leu Gly Ser Pro Ser Arg Ser 
        35                  40                  45              


Leu Ala Ser Thr Gly Ala Ser Gly Lys Asp Gly Ser Asn Leu Val Tyr 
    50                  55                  60                  


Phe Leu Ile Val Gly Ala Thr Val Thr Gly Ala Gly Val Tyr Tyr Ala 
65                  70                  75                  80  


Tyr Lys Thr Met Lys Glu Asp Glu Lys Arg Tyr Asn Glu Arg Ile Ser 
                85                  90                  95      


Gly Leu Gly Leu Thr Pro Glu Gln Lys Gln Lys Lys Ala Ala Leu Ser 
            100                 105                 110         


Ala Ser Glu Gly Glu Glu Val Pro Gln Asp Lys Ala Pro Ser His Val 
        115                 120                 125             


Pro Phe Leu Leu Ile Gly Gly Gly Thr Ala Ala Phe Ala Ala Ala Arg 
    130                 135                 140                 


Ser Ile Arg Ala Arg Asp Pro Gly Ala Arg Val Leu Ile Val Ser Glu 
145                 150                 155                 160 


Asp Pro Glu Leu Pro Tyr Met Arg Pro Pro Leu Ser Lys Glu Leu Trp 
                165                 170                 175     


Phe Ser Asp Asp Pro Asn Val Thr Lys Thr Leu Arg Phe Lys Gln Trp 
            180                 185                 190         


Asn Gly Lys Glu Arg Ser Ile Tyr Phe Gln Pro Pro Ser Phe Tyr Val 
        195                 200                 205             


Ser Ala Gln Asp Leu Pro His Ile Glu Asn Gly Gly Val Ala Val Leu 
    210                 215                 220                 


Thr Gly Lys Lys Val Val Gln Leu Asp Val Arg Asp Asn Met Val Lys 
225                 230                 235                 240 


Leu Asn Asp Gly Ser Gln Ile Thr Tyr Glu Lys Cys Leu Ile Ala Thr 
                245                 250                 255     


Gly Gly Thr Pro Arg Ser Leu Ser Ala Ile Asp Arg Ala Gly Ala Glu 
            260                 265                 270         


Val Lys Ser Arg Thr Thr Leu Phe Arg Lys Ile Gly Asp Phe Arg Ser 
        275                 280                 285             


Leu Glu Lys Ile Ser Arg Glu Val Lys Ser Ile Thr Ile Ile Gly Gly 
    290                 295                 300                 


Gly Phe Leu Gly Ser Glu Leu Ala Cys Ala Leu Gly Arg Lys Ala Arg 
305                 310                 315                 320 


Ala Leu Gly Thr Glu Val Ile Gln Leu Phe Pro Glu Lys Gly Asn Met 
                325                 330                 335     


Gly Lys Ile Leu Pro Glu Tyr Leu Ser Asn Trp Thr Met Glu Lys Val 
            340                 345                 350         


Arg Arg Glu Gly Val Lys Val Met Pro Asn Ala Ile Val Gln Ser Val 
        355                 360                 365             


Gly Val Ser Ser Gly Lys Leu Leu Ile Lys Leu Lys Asp Gly Arg Lys 
    370                 375                 380                 


Val Glu Thr Asp His Ile Val Ala Ala Val Gly Leu Glu Pro Asn Val 
385                 390                 395                 400 


Glu Leu Ala Lys Thr Gly Gly Leu Glu Ile Asp Ser Asp Phe Gly Gly 
                405                 410                 415     


Phe Arg Val Asn Ala Glu Leu Gln Ala Arg Ser Asn Ile Trp Val Ala 
            420                 425                 430         


Gly Asp Ala Ala Cys Phe Tyr Asp Ile Lys Leu Gly Arg Arg Arg Val 
        435                 440                 445             


Glu His His Asp His Ala Val Val Ser Gly Arg Leu Ala Gly Glu Asn 
    450                 455                 460                 


Met Thr Gly Ala Ala Lys Pro Tyr Trp His Gln Ser Met Phe Trp Ser 
465                 470                 475                 480 


Asp Leu Gly Pro Asp Val Gly Tyr Glu Ala Ile Gly Leu Val Asp Ser 
                485                 490                 495     


Ser Leu Pro Thr Val Gly Val Phe Ala Lys Ala Thr Ala Gln Asp Asn 
            500                 505                 510         


Pro Lys Ser Ala Thr Glu Gln Ser Gly Thr Gly Ile Arg Ser Glu Ser 
        515                 520                 525             


Glu Thr Glu Ser Glu Ala Ser Glu Ile Thr Ile Pro Pro Ser Thr Pro 
    530                 535                 540                 


Ala Val Pro Gln Ala Pro Val Gln Gly Glu Asp Tyr Gly Lys Gly Val 
545                 550                 555                 560 


Ile Phe Tyr Leu Arg Asp Lys Val Val Val Gly Ile Val Leu Trp Asn 
                565                 570                 575     


Ile Phe Asn Arg Met Pro Ile Ala Arg Lys Ile Ile Lys Asp Gly Glu 
            580                 585                 590         


Gln His Glu Asp Leu Asn Glu Val Ala Lys Leu Phe Asn Ile His Glu 
        595                 600                 605             


Asp 
    


<210>  5983
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  5983

Met Met Trp Ser Asn Phe Phe Leu Gln Glu Glu Asn Arg Arg Arg Gly 
1               5                   10                  15      


Ala Ala Gly Arg Arg Arg Ala His Gly Gln Gly Arg Ser Gly Leu Thr 
            20                  25                  30          


Pro Glu Arg Glu Gly Lys Val Lys Leu Ala Leu Leu Leu Ala Ala Val 
        35                  40                  45              


Gly Ala Thr Leu Ala Val Leu Ser Val Gly Thr Glu Phe Trp Val Glu 
    50                  55                  60                  


Leu Asn Thr Tyr Lys Ala Asn Gly Ser Ala Val Cys Glu Ala Ala His 
65                  70                  75                  80  


Leu Gly Leu Trp Lys Ala Cys Thr Lys Arg Leu Trp Gln Ala Asp Val 
                85                  90                  95      


Pro Val Asp Arg Asp Thr Cys Gly Pro Ala Glu Leu Pro Gly Glu Ala 
            100                 105                 110         


Asn Cys Thr Tyr Phe Lys Phe Phe Thr Thr Gly Glu Asn Ala Arg Ile 
        115                 120                 125             


Phe Gln Arg Thr Thr Lys Lys Glu Val Asn Leu Ala Ala Ala Val Ile 
    130                 135                 140                 


Ala Val Leu Gly Leu Ala Val Met Ala Leu Gly Cys Leu Cys Ile Ile 
145                 150                 155                 160 


Met Val Leu Ser Lys Gly Ala Glu Phe Leu Leu Arg Val Gly Ala Val 
                165                 170                 175     


Cys Phe Gly Leu Ser Gly Leu Leu Leu Leu Val Ser Leu Glu Val Phe 
            180                 185                 190         


Arg His Ser Val Arg Ala Leu Leu Gln Arg Val Ser Pro Glu Pro Pro 
        195                 200                 205             


Pro Ala Pro Arg Leu Thr Tyr Glu Tyr Ser Trp Ser Leu Gly Cys Gly 
    210                 215                 220                 


Val Gly Ala Gly Leu Ile Leu Leu Leu Gly Ala Gly Cys Phe Leu Leu 
225                 230                 235                 240 


Leu Thr Leu Pro Ser Trp Pro Trp Gly Ser Leu Cys Pro Lys Arg Gly 
                245                 250                 255     


His Arg Ala Thr 
            260 


<210>  5984
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  5984

Met Met Trp Ser Asn Phe Phe Leu Gln Glu Glu Asn Arg Arg Arg Gly 
1               5                   10                  15      


Ala Ala Gly Arg Arg Arg Ala His Gly Gln Gly Arg Ser Gly Leu Thr 
            20                  25                  30          


Pro Glu Arg Glu Gly Lys Val Lys Leu Ala Leu Leu Leu Ala Ala Val 
        35                  40                  45              


Gly Ala Thr Leu Ala Val Leu Ser Val Gly Thr Glu Phe Trp Val Glu 
    50                  55                  60                  


Leu Asn Thr Tyr Lys Ala Asn Gly Ser Ala Val Cys Glu Ala Ala His 
65                  70                  75                  80  


Leu Gly Leu Trp Lys Ala Cys Thr Lys Arg Leu Trp Gln Ala Asp Val 
                85                  90                  95      


Pro Val Asp Arg Asp Thr Cys Gly Pro Ala Glu Leu Pro Gly Glu Ala 
            100                 105                 110         


Asn Cys Thr Tyr Phe Lys Phe Phe Thr Thr Gly Glu Asn Ala Arg Ile 
        115                 120                 125             


Phe Gln Arg Thr Thr Lys Lys Gly Leu Leu Leu Leu Val Ser Leu Glu 
    130                 135                 140                 


Val Phe Arg His Ser Val Arg Ala Leu Leu Gln Arg Val Ser Pro Glu 
145                 150                 155                 160 


Pro Pro Pro Ala Pro Arg Leu Thr Tyr Glu Tyr Ser Trp Ser Leu Gly 
                165                 170                 175     


Cys Gly Val Gly Ala Gly Leu Ile Leu Leu Leu Gly Ala Gly Cys Phe 
            180                 185                 190         


Leu Leu Leu Thr Leu Pro Ser Trp Pro Trp Gly Ser Leu Cys Pro Lys 
        195                 200                 205             


Arg Gly His Arg Ala Thr 
    210                 


<210>  5985
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  5985

Met Lys Asp Glu Val Ala Leu Leu Ala Ala Val Thr Leu Leu Gly Val 
1               5                   10                  15      


Leu Leu Gln Ala Tyr Phe Ser Leu Gln Val Ile Ser Ala Arg Arg Ala 
            20                  25                  30          


Phe Arg Val Ser Pro Pro Leu Thr Thr Gly Pro Pro Glu Phe Glu Arg 
        35                  40                  45              


Val Tyr Arg Ala Gln Val Asn Cys Ser Glu Tyr Phe Pro Leu Phe Leu 
    50                  55                  60                  


Ala Thr Leu Trp Val Ala Gly Ile Phe Phe His Glu Gly Ala Ala Ala 
65                  70                  75                  80  


Leu Cys Gly Leu Val Tyr Leu Phe Ala Arg Leu Arg Tyr Phe Gln Gly 
                85                  90                  95      


Tyr Ala Arg Ser Ala Gln Leu Arg Leu Ala Pro Leu Tyr Ala Ser Ala 
            100                 105                 110         


Arg Ala Leu Trp Leu Leu Val Ala Leu Ala Ala Leu Gly Leu Leu Ala 
        115                 120                 125             


His Phe Leu Pro Ala Ala Leu Arg Ala Ala Leu Leu Gly Arg Leu Arg 
    130                 135                 140                 


Thr Leu Leu Pro Trp Ala 
145                 150 


<210>  5986
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  5986

Met Glu Asn Gln Pro Val Arg Trp Arg Ala Leu Pro Gly Leu Pro Arg 
1               5                   10                  15      


Pro Pro Gly Leu Pro Ala Ala Pro Trp Leu Leu Leu Gly Val Leu Leu 
            20                  25                  30          


Leu Pro Gly Thr Leu Arg Leu Ala Gly Gly Gln Ser Val Thr His Thr 
        35                  40                  45              


Gly Leu Pro Ile Met Ala Ser Leu Ala Asn Thr Ala Ile Ser Phe Ser 
    50                  55                  60                  


Cys Arg Ile Thr Tyr Pro Tyr Thr Pro Gln Phe Lys Val Phe Thr Val 
65                  70                  75                  80  


Ser Tyr Phe His Glu Asp Leu Gln Gly Gln Arg Ser Pro Lys Lys Pro 
                85                  90                  95      


Thr Asn Cys His Pro Gly Leu Gly Thr Glu Asn Gln Ser His Thr Leu 
            100                 105                 110         


Asp Cys Gln Val Thr Leu Val Leu Pro Gly Ala Ser Ala Thr Gly Thr 
        115                 120                 125             


Tyr Tyr Cys Ser Val His Trp Pro His Ser Thr Val Arg Gly Ser Gly 
    130                 135                 140                 


Thr Phe Ile Leu Val Arg Asp Ala Gly Tyr Arg Glu Pro Pro Gln Ser 
145                 150                 155                 160 


Pro Gln Lys Leu Leu Leu Phe Gly Phe Thr Gly Leu Leu Ser Val Leu 
                165                 170                 175     


Ser Val Val Gly Thr Ala Leu Leu Leu Trp Asn Lys Lys Arg Met Arg 
            180                 185                 190         


Gly Pro Gly Lys Asp Pro Thr Arg Lys Cys Pro Asp Pro Arg Ser Ala 
        195                 200                 205             


Ser Ser Pro Lys Gln His Pro Ser Glu Ser Val Tyr Thr Ala Leu Gln 
    210                 215                 220                 


Arg Arg Glu Thr Glu Val Tyr Ala Cys Ile Glu Asn Glu Asp Gly Ser 
225                 230                 235                 240 


Ser Pro Thr Ala Lys Gln Ser Pro Leu Ser Gln Glu Arg Pro His Arg 
                245                 250                 255     


Phe Glu Asp Asp Gly Glu Leu Asn Leu Val Tyr Glu Asn Leu 
            260                 265                 270 


<210>  5987
<211>  610
<212>  PRT
<213>  Homo sapiens

<400>  5987

Met Asp Thr Pro Arg Gly Ile Gly Thr Phe Val Val Trp Asp Tyr Val 
1               5                   10                  15      


Val Phe Ala Gly Met Leu Val Ile Ser Ala Ala Ile Gly Ile Tyr Tyr 
            20                  25                  30          


Ala Phe Ala Gly Gly Gly Gln Gln Thr Ser Lys Asp Phe Leu Met Gly 
        35                  40                  45              


Gly Arg Arg Met Thr Ala Val Pro Val Ala Leu Ser Leu Thr Ala Ser 
    50                  55                  60                  


Phe Met Ser Ala Val Thr Val Leu Gly Thr Pro Ser Glu Val Tyr Arg 
65                  70                  75                  80  


Phe Gly Ala Ile Phe Ser Ile Phe Ala Phe Thr Tyr Phe Phe Val Val 
                85                  90                  95      


Val Ile Ser Ala Glu Val Phe Leu Pro Val Phe Tyr Lys Leu Gly Ile 
            100                 105                 110         


Thr Ser Thr Tyr Glu Tyr Leu Glu Leu Arg Phe Asn Lys Cys Val Arg 
        115                 120                 125             


Leu Cys Gly Thr Val Leu Phe Ile Val Gln Thr Ile Leu Tyr Thr Gly 
    130                 135                 140                 


Ile Val Ile Tyr Ala Pro Ala Leu Ala Leu Asn Gln Val Thr Gly Phe 
145                 150                 155                 160 


Asp Leu Trp Gly Ala Val Val Ala Thr Gly Val Val Cys Thr Phe Tyr 
                165                 170                 175     


Cys Thr Leu Gly Gly Leu Lys Ala Val Ile Trp Thr Asp Val Phe Gln 
            180                 185                 190         


Val Gly Ile Met Val Ala Gly Phe Ala Ser Val Ile Ile Gln Ala Val 
        195                 200                 205             


Val Met Gln Gly Gly Ile Ser Thr Ile Leu Asn Asp Ala Tyr Asp Gly 
    210                 215                 220                 


Gly Arg Leu Asn Phe Trp Asn Phe Asn Pro Asn Pro Leu Gln Arg His 
225                 230                 235                 240 


Thr Phe Trp Thr Ile Ile Ile Gly Gly Thr Phe Thr Trp Thr Ser Ile 
                245                 250                 255     


Tyr Gly Val Asn Gln Ser Gln Val Gln Arg Tyr Ile Ser Cys Lys Ser 
            260                 265                 270         


Arg Phe Gln Ala Lys Leu Ser Leu Tyr Ile Asn Leu Val Gly Leu Trp 
        275                 280                 285             


Ala Ile Leu Thr Cys Ser Val Phe Cys Gly Leu Ala Leu Tyr Ser Arg 
    290                 295                 300                 


Tyr His Asp Cys Asp Pro Trp Thr Ala Lys Lys Val Ser Ala Pro Asp 
305                 310                 315                 320 


Gln Leu Met Pro Tyr Leu Val Leu Asp Ile Leu Gln Asp Tyr Pro Gly 
                325                 330                 335     


Leu Pro Gly Leu Phe Val Ala Cys Ala Tyr Ser Gly Thr Leu Ser Thr 
            340                 345                 350         


Val Ser Ser Ser Ile Asn Ala Leu Ala Ala Val Thr Val Glu Asp Leu 
        355                 360                 365             


Ile Lys Pro Tyr Phe Arg Ser Leu Ser Glu Arg Ser Leu Ser Trp Ile 
    370                 375                 380                 


Ser Gln Gly Met Ser Val Val Tyr Gly Ala Leu Cys Ile Gly Met Ala 
385                 390                 395                 400 


Ala Leu Ala Ser Leu Met Gly Ala Leu Leu Gln Ala Ala Leu Ser Val 
                405                 410                 415     


Phe Gly Met Val Gly Gly Pro Leu Met Gly Leu Phe Ala Leu Gly Ile 
            420                 425                 430         


Leu Val Pro Phe Ala Asn Ser Ile Gly Ala Leu Val Gly Leu Met Ala 
        435                 440                 445             


Gly Phe Ala Ile Ser Leu Trp Val Gly Ile Gly Ala Gln Ile Tyr Pro 
    450                 455                 460                 


Pro Leu Pro Glu Arg Thr Leu Pro Leu His Leu Asp Ile Gln Gly Cys 
465                 470                 475                 480 


Asn Ser Thr Tyr Asn Glu Thr Asn Leu Met Thr Thr Thr Glu Met Pro 
                485                 490                 495     


Phe Thr Thr Ser Val Phe Gln Ile Tyr Asn Val Gln Arg Thr Pro Leu 
            500                 505                 510         


Met Asp Asn Trp Tyr Ser Leu Ser Tyr Leu Tyr Phe Ser Thr Val Gly 
        515                 520                 525             


Thr Leu Val Thr Leu Leu Val Gly Ile Leu Val Ser Leu Ser Thr Gly 
    530                 535                 540                 


Gly Arg Lys Gln Asn Leu Asp Pro Arg Tyr Ile Leu Thr Lys Glu Asp 
545                 550                 555                 560 


Phe Leu Ser Asn Phe Asp Ile Phe Lys Lys Lys Lys His Val Leu Ser 
                565                 570                 575     


Tyr Lys Ser His Pro Val Glu Asp Gly Gly Thr Asp Asn Pro Ala Phe 
            580                 585                 590         


Asn His Ile Glu Leu Asn Ser Asp Gln Ser Gly Lys Ser Asn Gly Thr 
        595                 600                 605             


Arg Leu 
    610 


<210>  5988
<211>  1308
<212>  PRT
<213>  Homo sapiens

<400>  5988

Met Asp Pro Ser Gly Ser Arg Gly Arg Pro Thr Trp Val Leu Ala Gly 
1               5                   10                  15      


Gly Leu Leu Ala Val Ala Leu Ala Leu Gly Gly Arg Gly Cys Leu Gly 
            20                  25                  30          


Ala Ser Ser Arg Pro Arg Trp Arg Pro Leu Gly Ala Gln Pro Pro Arg 
        35                  40                  45              


Asp Pro Gln Val Ala Pro Arg Ser Gly Pro Gly Leu Arg Ile Pro Pro 
    50                  55                  60                  


Gly Arg Ser Gly Ala Gly Pro Glu Ser Ser Thr Gln Asp Leu Pro Cys 
65                  70                  75                  80  


Met Ile Trp Pro Lys Val Glu Cys Cys His Phe Lys Thr Ala Val Glu 
                85                  90                  95      


Ala Pro Leu Gly Met Lys Leu Asp Lys Lys Met Glu Val Phe Ile Pro 
            100                 105                 110         


Leu Ser Thr Ser Ala Ala Ser Ser Gly Pro Trp Ala His Ser Leu Phe 
        115                 120                 125             


Ala Phe Ile Pro Ser Trp Pro Lys Lys Asn Leu Phe Lys Arg Glu Ser 
    130                 135                 140                 


Pro Ile Thr His Arg Leu Tyr Gly Asp Ile Ser Arg Glu Val Gln Gly 
145                 150                 155                 160 


Thr Ser Glu Asn Gly Val Ile Phe Gln Lys Cys Ala Leu Val Ser Gly 
                165                 170                 175     


Ser Ser Glu Ala Gln Thr Ala Arg Ile Trp Leu Leu Val Asn Asn Thr 
            180                 185                 190         


Lys Thr Thr Ser Ser Ala Asn Leu Ser Glu Leu Leu Leu Leu Asp Ser 
        195                 200                 205             


Ile Ala Gly Leu Thr Ile Trp Asp Ser Val Gly Asn Arg Thr Ser Glu 
    210                 215                 220                 


Gly Phe Gln Ala Phe Ser Lys Lys Phe Leu Gln Val Gly Asp Ala Phe 
225                 230                 235                 240 


Ala Val Ser Tyr Ala Ala Thr Leu Gln Ala Gly Asp Leu Gly Asn Gly 
                245                 250                 255     


Glu Ser Leu Lys Leu Pro Ala Gln Leu Thr Phe Gln Ser Ser Ser Arg 
            260                 265                 270         


Asn Arg Thr Gln Leu Lys Val Leu Phe Ser Ile Thr Ala Glu Glu Asn 
        275                 280                 285             


Val Thr Val Leu Pro His His Gly Leu His Ala Ala Gly Phe Phe Ile 
    290                 295                 300                 


Ala Phe Leu Leu Ser Leu Val Leu Thr Trp Ala Ala Leu Phe Leu Met 
305                 310                 315                 320 


Val Arg Tyr Gln Cys Leu Lys Gly Asn Met Leu Thr Arg His Arg Val 
                325                 330                 335     


Trp Gln Tyr Glu Ser Lys Leu Glu Pro Leu Pro Phe Thr Ser Ala Asp 
            340                 345                 350         


Gly Val Asn Glu Asp Leu Ser Leu Asn Asp Gln Met Ile Asp Ile Leu 
        355                 360                 365             


Ser Ser Glu Asp Pro Gly Ser Met Leu Gln Ala Leu Glu Glu Leu Glu 
    370                 375                 380                 


Ile Ala Thr Leu Asn Arg Ala Asp Ala Asp Leu Glu Ala Cys Arg Thr 
385                 390                 395                 400 


Gln Ile Ser Lys Asp Ile Ile Ala Leu Leu Leu Lys Asn Leu Thr Ser 
                405                 410                 415     


Ser Gly His Leu Ser Pro Gln Val Glu Arg Lys Met Ser Ala Val Phe 
            420                 425                 430         


Lys Lys Gln Phe Leu Leu Leu Glu Asn Glu Ile Gln Glu Glu Tyr Asp 
        435                 440                 445             


Arg Lys Met Val Ala Leu Thr Ala Glu Cys Asp Leu Glu Thr Arg Lys 
    450                 455                 460                 


Lys Met Glu Asn Gln Tyr Gln Arg Glu Met Met Ala Met Glu Glu Ala 
465                 470                 475                 480 


Glu Glu Leu Leu Lys Arg Ala Gly Glu Arg Ser Ala Val Glu Cys Ser 
                485                 490                 495     


Asn Leu Leu Arg Thr Leu His Gly Leu Glu Gln Glu His Leu Arg Lys 
            500                 505                 510         


Ser Leu Ala Leu Gln Gln Glu Glu Asp Phe Ala Lys Ala His Arg Gln 
        515                 520                 525             


Leu Ala Val Phe Gln Arg Asn Glu Leu His Ser Ile Phe Phe Thr Gln 
    530                 535                 540                 


Ile Lys Ser Ala Ile Phe Lys Gly Glu Leu Lys Pro Glu Ala Ala Lys 
545                 550                 555                 560 


Met Leu Leu Gln Asn Tyr Ser Lys Ile Gln Glu Asn Val Glu Glu Leu 
                565                 570                 575     


Met Asp Phe Phe Gln Ala Ser Lys Arg Tyr His Leu Ser Lys Arg Phe 
            580                 585                 590         


Gly His Arg Glu Tyr Leu Val Gln Asn Leu Gln Ser Ser Glu Thr Arg 
        595                 600                 605             


Val Gln Gly Leu Leu Ser Thr Ala Ala Ala Gln Leu Thr His Leu Ile 
    610                 615                 620                 


Gln Lys His Glu Arg Ala Gly Tyr Leu Asp Glu Asp Gln Met Glu Met 
625                 630                 635                 640 


Leu Leu Glu Arg Ala Gln Thr Glu Val Phe Ser Ile Lys Gln Lys Leu 
                645                 650                 655     


Asp Asn Asp Leu Lys Gln Glu Lys Lys Lys Leu His Gln Lys Leu Ile 
            660                 665                 670         


Thr Lys Arg Arg Arg Glu Leu Leu Gln Lys His Arg Glu Gln Arg Arg 
        675                 680                 685             


Glu Gln Ala Ser Val Gly Glu Ala Phe Arg Thr Val Glu Asp Ala Gly 
    690                 695                 700                 


Gln Tyr Leu His Gln Lys Arg Ser Leu Met Glu Glu His Gly Ala Thr 
705                 710                 715                 720 


Leu Glu Glu Leu Gln Glu Arg Leu Asp Gln Ala Ala Leu Asp Asp Leu 
                725                 730                 735     


Arg Thr Leu Thr Leu Ser Leu Phe Glu Lys Ala Thr Asp Glu Leu Arg 
            740                 745                 750         


Arg Leu Gln Asn Ser Ala Met Thr Gln Glu Leu Leu Lys Arg Gly Val 
        755                 760                 765             


Pro Trp Leu Phe Leu Gln Gln Ile Leu Glu Glu His Gly Lys Glu Met 
    770                 775                 780                 


Ala Ala Arg Ala Glu Gln Leu Glu Gly Glu Glu Arg Asp Arg Asp Gln 
785                 790                 795                 800 


Glu Gly Val Gln Ser Val Arg Gln Arg Leu Lys Asp Asp Ala Pro Glu 
                805                 810                 815     


Ala Val Thr Glu Glu Gln Ala Glu Leu Arg Arg Trp Glu His Leu Ile 
            820                 825                 830         


Phe Met Lys Leu Cys Ser Ser Val Phe Ser Leu Ser Glu Glu Glu Leu 
        835                 840                 845             


Leu Arg Met Arg Gln Glu Val His Gly Cys Phe Ala Gln Met Asp Arg 
    850                 855                 860                 


Ser Leu Ala Leu Pro Lys Ile Arg Ala Arg Val Leu Leu Gln Gln Phe 
865                 870                 875                 880 


Gln Thr Ala Trp Arg Glu Ala Glu Phe Val Lys Leu Asp Gln Ala Val 
                885                 890                 895     


Ala Ala Pro Glu Leu Gln Gln Gln Ser Lys Val Arg Lys Ser Arg Ser 
            900                 905                 910         


Lys Ser Lys Ser Lys Gly Glu Leu Leu Lys Lys Cys Ile Glu Asp Lys 
        915                 920                 925             


Ile His Leu Cys Glu Glu Gln Ala Ser Glu Asp Leu Val Glu Lys Val 
    930                 935                 940                 


Arg Gly Glu Leu Leu Arg Glu Arg Val Gln Arg Met Glu Ala Gln Glu 
945                 950                 955                 960 


Gly Gly Phe Ala Gln Ser Leu Val Ala Leu Gln Phe Gln Lys Ala Ser 
                965                 970                 975     


Arg Val Thr Glu Thr Leu Ser Ala Tyr Thr Ala Leu Leu Ser Ile Gln 
            980                 985                 990         


Asp Leu Leu Leu Glu Glu Leu Ser  Ala Ser Glu Met Leu  Thr Lys Ser 
        995                 1000                 1005             


Ala Cys  Thr Gln Ile Leu Glu  Ser His Ser Arg Glu  Leu Gln Glu 
    1010                 1015                 1020             


Leu Glu  Arg Lys Leu Glu Asp  Gln Leu Val Gln Gln  Glu Ala Ala 
    1025                 1030                 1035             


Gln Gln  Gln Gln Ala Leu Ala  Ser Trp Gln Gln Trp  Val Ala Asp 
    1040                 1045                 1050             


Gly Pro  Gly Ile Leu Asn Glu  Pro Gly Glu Val Asp  Ser Glu Arg 
    1055                 1060                 1065             


Gln Val  Ser Thr Val Leu His  Gln Ala Leu Ser Lys  Ser Gln Thr 
    1070                 1075                 1080             


Leu Leu  Glu Gln His Gln Gln  Cys Leu Arg Glu Glu  Gln Gln Asn 
    1085                 1090                 1095             


Ser Val  Val Leu Glu Asp Leu  Leu Glu Asn Met Glu  Ala Asp Thr 
    1100                 1105                 1110             


Phe Ala  Thr Leu Cys Ser Gln  Glu Leu Arg Leu Ala  Ser Tyr Leu 
    1115                 1120                 1125             


Ala Arg  Met Ala Met Val Pro  Gly Ala Thr Leu Arg  Arg Leu Leu 
    1130                 1135                 1140             


Ser Val  Val Leu Pro Thr Ala  Ser Gln Pro Gln Leu  Leu Ala Leu 
    1145                 1150                 1155             


Leu Asp  Ser Ala Thr Glu Arg  His Val Asp His Ala  Ala Glu Ser 
    1160                 1165                 1170             


Asp Gly  Gly Ala Glu Gln Ala  Asp Val Gly Arg Arg  Arg Lys His 
    1175                 1180                 1185             


Gln Ser  Trp Trp Gln Ala Leu  Asp Gly Lys Leu Arg  Gly Asp Leu 
    1190                 1195                 1200             


Ile Ser  Arg Gly Leu Glu Lys  Met Leu Trp Ala Arg  Lys Arg Lys 
    1205                 1210                 1215             


Gln Ser  Ile Leu Lys Lys Thr  Cys Leu Pro Leu Arg  Glu Arg Met 
    1220                 1225                 1230             


Ile Phe  Ser Gly Lys Gly Ser  Trp Pro His Leu Ser  Leu Glu Pro 
    1235                 1240                 1245             


Ile Gly  Glu Leu Ala Pro Val  Pro Ile Val Gly Ala  Glu Thr Ile 
    1250                 1255                 1260             


Asp Leu  Leu Asn Thr Gly Glu  Lys Leu Phe Ile Phe  Arg Asn Pro 
    1265                 1270                 1275             


Lys Glu  Pro Glu Ile Ser Leu  His Val Pro Pro Arg  Lys Lys Lys 
    1280                 1285                 1290             


Asn Phe  Leu Asn Ala Lys Lys  Ala Met Arg Ala Leu  Gly Met Asp 
    1295                 1300                 1305             


<210>  5989
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  5989

Met Ala Trp Met Leu Leu Leu Ile Leu Ile Met Val His Pro Gly Ser 
1               5                   10                  15      


Cys Ala Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly 
            20                  25                  30          


Ser Ser Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu 
        35                  40                  45              


Ala Ile Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys 
    50                  55                  60                  


Glu Val Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu 
65                  70                  75                  80  


Ala Ser Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg 
                85                  90                  95      


Asp Val Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val 
            100                 105                 110         


Leu Gly Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu 
        115                 120                 125             


Lys Glu His Pro Gln Leu Gly Ala Gly Thr Val Leu Leu Leu Arg Ala 
    130                 135                 140                 


Gly Phe Tyr Ala Val Ser Phe Leu Ser Val Ala Val Gly Ser Thr Val 
145                 150                 155                 160 


Tyr Tyr Gln Gly Lys Cys Leu Thr Trp Lys Gly Pro Arg Arg Gln Leu 
                165                 170                 175     


Pro Ala Val Val Pro Ala Pro Leu Pro Pro Pro Cys Gly Ser Ser Ala 
            180                 185                 190         


His Leu Leu Pro Pro Val Pro Gly Gly 
        195                 200     


<210>  5990
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  5990

Met Asn Tyr Thr Glu Ser Ser Pro Leu Arg Glu Ser Thr Ala Ile Gly 
1               5                   10                  15      


Phe Thr Pro Glu Leu Glu Ser Ile Ile Pro Val Pro Ser Asn Lys Thr 
            20                  25                  30          


Thr Cys Glu Asn Trp Arg Glu Ile His His Leu Val Phe His Val Ala 
        35                  40                  45              


Asn Ile Cys Phe Ala Val Gly Leu Val Ile Pro Thr Thr Leu His Leu 
    50                  55                  60                  


His Met Ile Phe Leu Arg Gly Met Leu Thr Leu Gly Cys Thr Leu Tyr 
65                  70                  75                  80  


Ile Val Trp Ala Thr Leu Tyr Arg Cys Ala Leu Asp Ile Met Ile Trp 
                85                  90                  95      


Asn Ser Val Phe Leu Gly Val Asn Ile Leu His Leu Ser Tyr Leu Leu 
            100                 105                 110         


Tyr Lys Lys Arg Pro Val Lys Ile Glu Lys Glu Leu Ser Gly Met Tyr 
        115                 120                 125             


Arg Arg Leu Phe Glu Pro Leu Arg Val Pro Pro Asp Leu Phe Arg Arg 
    130                 135                 140                 


Leu Thr Gly Gln Phe Cys Met Ile Gln Thr Leu Lys Lys Gly Gln Thr 
145                 150                 155                 160 


Tyr Ala Ala Glu Asp Lys Thr Ser Val Asp Asp Arg Leu Ser Ile Leu 
                165                 170                 175     


Leu Lys Gly Lys Met Lys Val Ser Tyr Arg Gly His Phe Leu His Asn 
            180                 185                 190         


Ile Tyr Pro Cys Ala Phe Ile Asp Ser Pro Glu Phe Arg Ser Thr Gln 
        195                 200                 205             


Met His Lys Gly Glu Lys Phe Gln Val Thr Ile Ile Ala Asp Asp Asn 
    210                 215                 220                 


Cys Arg Phe Leu Cys Trp Ser Arg Glu Arg Leu Thr Tyr Phe Leu Glu 
225                 230                 235                 240 


Ser Glu Pro Phe Leu Tyr Glu Ile Phe Arg Tyr Leu Ile Gly Lys Asp 
                245                 250                 255     


Ile Thr Asn Lys Leu Tyr Ser Leu Asn Asp Pro Thr Leu Asn Asp Lys 
            260                 265                 270         


Lys Ala Lys Lys Leu Glu His Gln Leu Ser Leu Cys Thr Gln Ile Ser 
        275                 280                 285             


Met Leu Glu Met Arg Asn Ser Ile Ala Ser Ser Ser Asp Ser Asp Asp 
    290                 295                 300                 


Gly Leu His Gln Phe Leu Arg Gly Thr Ser Ser Met Ser Ser Leu His 
305                 310                 315                 320 


Val Ser Ser Pro His Gln Arg Ala Ser Ala Lys Met Lys Pro Ile Glu 
                325                 330                 335     


Glu Gly Ala Glu Asp Asp Asp Asp Val Phe Glu Pro Ala Ser Pro Asn 
            340                 345                 350         


Thr Leu Lys Val His Gln Leu Pro 
        355                 360 


<210>  5991
<211>  413
<212>  PRT
<213>  Homo sapiens

<400>  5991

Met Lys Glu Val Val Tyr Trp Ser Pro Lys Lys Val Ala Asp Trp Leu 
1               5                   10                  15      


Leu Glu Asn Ala Met Pro Glu Tyr Cys Glu Pro Leu Glu His Phe Thr 
            20                  25                  30          


Gly Gln Asp Leu Ile Asn Leu Thr Gln Glu Asp Phe Lys Lys Pro Pro 
        35                  40                  45              


Leu Cys Arg Val Ser Ser Asp Asn Gly Gln Arg Leu Leu Asp Met Ile 
    50                  55                  60                  


Glu Thr Leu Lys Met Glu His His Leu Glu Ala His Lys Asn Gly His 
65                  70                  75                  80  


Ala Asn Gly His Leu Asn Ile Gly Val Asp Ile Pro Thr Pro Asp Gly 
                85                  90                  95      


Ser Phe Ser Ile Lys Ile Lys Pro Asn Gly Met Pro Asn Gly Tyr Arg 
            100                 105                 110         


Lys Glu Met Ile Lys Ile Pro Met Pro Glu Leu Glu Arg Ser Gln Tyr 
        115                 120                 125             


Pro Met Glu Trp Gly Lys Thr Phe Leu Ala Phe Leu Tyr Ala Leu Ser 
    130                 135                 140                 


Cys Phe Val Leu Thr Thr Val Met Ile Ser Val Val His Glu Arg Val 
145                 150                 155                 160 


Pro Pro Lys Glu Val Gln Pro Pro Leu Pro Asp Thr Phe Phe Asp His 
                165                 170                 175     


Phe Asn Arg Val Gln Trp Ala Phe Ser Ile Cys Glu Ile Asn Gly Met 
            180                 185                 190         


Ile Leu Val Gly Leu Trp Leu Ile Gln Trp Leu Leu Leu Lys Tyr Lys 
        195                 200                 205             


Ser Ile Ile Ser Arg Arg Phe Phe Cys Ile Val Gly Thr Leu Tyr Leu 
    210                 215                 220                 


Tyr Arg Cys Ile Thr Met Tyr Val Thr Thr Leu Pro Val Pro Gly Met 
225                 230                 235                 240 


His Phe Asn Cys Ser Pro Lys Leu Phe Gly Asp Trp Glu Ala Gln Leu 
                245                 250                 255     


Arg Arg Ile Met Lys Leu Ile Ala Gly Gly Gly Leu Ser Ile Thr Gly 
            260                 265                 270         


Ser His Asn Met Cys Gly Asp Tyr Leu Tyr Ser Gly His Thr Val Met 
        275                 280                 285             


Leu Thr Leu Thr Tyr Leu Phe Ile Lys Glu Tyr Ser Pro Arg Arg Leu 
    290                 295                 300                 


Trp Trp Tyr His Trp Ile Cys Trp Leu Leu Ser Val Val Gly Ile Phe 
305                 310                 315                 320 


Cys Ile Leu Leu Ala His Asp His Tyr Thr Val Asp Val Val Val Ala 
                325                 330                 335     


Tyr Tyr Ile Thr Thr Arg Leu Phe Trp Trp Tyr His Thr Met Ala Asn 
            340                 345                 350         


Gln Gln Val Leu Lys Glu Ala Ser Gln Met Asn Leu Leu Ala Arg Val 
        355                 360                 365             


Trp Trp Tyr Arg Pro Phe Gln Tyr Phe Glu Lys Asn Val Gln Gly Ile 
    370                 375                 380                 


Val Pro Arg Ser Tyr His Trp Pro Phe Pro Trp Pro Val Val His Leu 
385                 390                 395                 400 


Ser Arg Gln Val Lys Tyr Ser Arg Leu Val Asn Asp Thr 
                405                 410             


<210>  5992
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  5992

Met Gln Trp Ala Val Gly Arg Arg Trp Ala Trp Ala Ala Leu Leu Leu 
1               5                   10                  15      


Ala Val Ala Ala Val Leu Thr Gln Val Val Trp Leu Trp Leu Gly Thr 
            20                  25                  30          


Gln Ser Phe Val Phe Gln Arg Glu Glu Ile Ala Gln Leu Ala Arg Gln 
        35                  40                  45              


Tyr Ala Gly Leu Asp His Glu Leu Ala Phe Ser Arg Leu Ile Val Glu 
    50                  55                  60                  


Leu Arg Arg Leu His Pro Gly His Val Leu Pro Asp Glu Glu Leu Gln 
65                  70                  75                  80  


Trp Val Phe Val Asn Ala Gly Gly Trp Met Gly Ala Met Cys Leu Leu 
                85                  90                  95      


His Ala Ser Leu Ser Glu Tyr Val Leu Leu Phe Gly Thr Ala Leu Gly 
            100                 105                 110         


Ser Arg Gly His Ser Gly Glu Thr Val Val His Gly Pro Gly Glu Ala 
        115                 120                 125             


Thr Ala Val Glu Trp Gly Pro Asn Thr Trp Met Val Glu Tyr Gly Arg 
    130                 135                 140                 


Gly Val Ile Pro Ser Thr Leu Ala Phe Ala Leu Ala Asp Thr Val Phe 
145                 150                 155                 160 


Ser Thr Gln Asp Phe Leu Thr Leu Phe Tyr Thr Leu Arg Ser Tyr Ala 
                165                 170                 175     


Arg Gly Leu Arg Leu Glu Leu Thr Thr Tyr Leu Phe Gly Gln Asp Pro 
            180                 185                 190         


<210>  5993
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  5993

Met Ser Ser Ser Cys Ser Gly Leu Ser Arg Val Leu Val Ala Val Ala 
1               5                   10                  15      


Thr Ala Leu Val Ser Ala Ser Ser Pro Cys Pro Gln Ala Trp Gly Pro 
            20                  25                  30          


Pro Gly Val Gln Tyr Gly Gln Pro Gly Arg Ser Val Lys Leu Cys Cys 
        35                  40                  45              


Pro Gly Val Thr Ala Gly Asp Pro Val Ser Trp Phe Arg Asp Gly Glu 
    50                  55                  60                  


Pro Lys Leu Leu Gln Gly Pro Asp Ser Gly Leu Gly His Glu Leu Val 
65                  70                  75                  80  


Leu Ala Gln Ala Asp Ser Thr Asp Glu Gly Thr Tyr Ile Cys Gln Thr 
                85                  90                  95      


Leu Asp Gly Ala Leu Gly Gly Thr Val Thr Leu Gln Leu Gly Tyr Pro 
            100                 105                 110         


Pro Ala Arg Pro Val Val Ser Cys Gln Ala Ala Asp Tyr Glu Asn Phe 
        115                 120                 125             


Ser Cys Thr Trp Ser Pro Ser Gln Ile Ser Gly Leu Pro Thr Arg Tyr 
    130                 135                 140                 


Leu Thr Ser Tyr Arg Lys Lys Thr Val Leu Gly Ala Asp Ser Gln Arg 
145                 150                 155                 160 


Arg Ser Pro Ser Thr Gly Pro Trp Pro Cys Pro Gln Asp Pro Leu Gly 
                165                 170                 175     


Ala Ala Arg Cys Val Val His Gly Ala Glu Phe Trp Ser Gln Tyr Arg 
            180                 185                 190         


Ile Asn Val Thr Glu Val Asn Pro Leu Gly Ala Ser Thr Arg Leu Leu 
        195                 200                 205             


Asp Val Ser Leu Gln Ser Ile Leu Arg Pro Asp Pro Pro Gln Gly Leu 
    210                 215                 220                 


Arg Val Glu Ser Val Pro Gly Tyr Pro Arg Arg Leu Arg Ala Ser Trp 
225                 230                 235                 240 


Thr Tyr Pro Ala Ser Trp Pro Cys Gln Pro His Phe Leu Leu Lys Phe 
                245                 250                 255     


Arg Leu Gln Tyr Arg Pro Ala Gln His Pro Ala Trp Ser Thr Val Glu 
            260                 265                 270         


Pro Ala Gly Leu Glu Glu Val Ile Thr Asp Ala Val Ala Gly Leu Pro 
        275                 280                 285             


His Ala Val Arg Val Ser Ala Arg Asp Phe Leu Asp Ala Gly Thr Trp 
    290                 295                 300                 


Ser Thr Trp Ser Pro Glu Ala Trp Gly Thr Pro Ser Thr Gly Thr Ile 
305                 310                 315                 320 


Pro Lys Glu Ile Pro Ala Trp Gly Gln Leu His Thr Gln Pro Glu Val 
                325                 330                 335     


Glu Pro Gln Val Asp Ser Pro Ala Pro Pro Arg Pro Ser Leu Gln Pro 
            340                 345                 350         


His Pro Arg Leu Leu Asp His Arg Asp Ser Val Glu Gln Val Ala Val 
        355                 360                 365             


Leu Ala Ser Leu Gly Ile Leu Ser Phe Leu Gly Leu Val Ala Gly Ala 
    370                 375                 380                 


Leu Ala Leu Gly Leu Trp Leu Arg Leu Arg Arg Gly Gly Lys Asp Gly 
385                 390                 395                 400 


Ser Pro Lys Pro Gly Phe Leu Ala Ser Val Ile Pro Val Asp Arg Arg 
                405                 410                 415     


Pro Gly Ala Pro Asn Leu 
            420         


<210>  5994
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  5994

Met Glu Gln Arg Gly Gln Asn Ala Pro Ala Ala Ser Gly Ala Arg Lys 
1               5                   10                  15      


Arg His Gly Pro Gly Pro Arg Glu Ala Arg Gly Ala Arg Pro Gly Pro 
            20                  25                  30          


Arg Val Pro Lys Thr Leu Val Leu Val Val Ala Ala Val Leu Leu Leu 
        35                  40                  45              


Val Ser Ala Glu Ser Ala Leu Ile Thr Gln Gln Asp Leu Ala Pro Gln 
    50                  55                  60                  


Gln Arg Ala Ala Pro Gln Gln Lys Arg Ser Ser Pro Ser Glu Gly Leu 
65                  70                  75                  80  


Cys Pro Pro Gly His His Ile Ser Glu Asp Gly Arg Asp Cys Ile Ser 
                85                  90                  95      


Cys Lys Tyr Gly Gln Asp Tyr Ser Thr His Trp Asn Asp Leu Leu Phe 
            100                 105                 110         


Cys Leu Arg Cys Thr Arg Cys Asp Ser Gly Glu Val Glu Leu Ser Pro 
        115                 120                 125             


Cys Thr Thr Thr Arg Asn Thr Val Cys Gln Cys Glu Glu Gly Thr Phe 
    130                 135                 140                 


Arg Glu Glu Asp Ser Pro Glu Met Cys Arg Lys Cys Arg Thr Gly Cys 
145                 150                 155                 160 


Pro Arg Gly Met Val Lys Val Gly Asp Cys Thr Pro Trp Ser Asp Ile 
                165                 170                 175     


Glu Cys Val His Lys Glu Ser Gly Ile Ile Ile Gly Val Thr Val Ala 
            180                 185                 190         


Ala Val Val Leu Ile Val Ala Val Phe Val Cys Lys Ser Leu Leu Trp 
        195                 200                 205             


Lys Lys Val Leu Pro Tyr Leu Lys Gly Ile Cys Ser Gly Gly Gly Gly 
    210                 215                 220                 


Asp Pro Glu Arg Val Asp Arg Ser Ser Gln Arg Pro Gly Ala Glu Asp 
225                 230                 235                 240 


Asn Val Leu Asn Glu Ile Val Ser Ile Leu Gln Pro Thr Gln Val Pro 
                245                 250                 255     


Glu Gln Glu Met Glu Val Gln Glu Pro Ala Glu Pro Thr Gly Val Asn 
            260                 265                 270         


Met Leu Ser Pro Gly Glu Ser Glu His Leu Leu Glu Pro Ala Glu Ala 
        275                 280                 285             


Glu Arg Ser Gln Arg Arg Arg Leu Leu Val Pro Ala Asn Glu Gly Asp 
    290                 295                 300                 


Pro Thr Glu Thr Leu Arg Gln Cys Phe Asp Asp Phe Ala Asp Leu Val 
305                 310                 315                 320 


Pro Phe Asp Ser Trp Glu Pro Leu Met Arg Lys Leu Gly Leu Met Asp 
                325                 330                 335     


Asn Glu Ile Lys Val Ala Lys Ala Glu Ala Ala Gly His Arg Asp Thr 
            340                 345                 350         


Leu Tyr Thr Met Leu Ile Lys Trp Val Asn Lys Thr Gly Arg Asp Ala 
        355                 360                 365             


Ser Val His Thr Leu Leu Asp Ala Leu Glu Thr Leu Gly Glu Arg Leu 
    370                 375                 380                 


Ala Lys Gln Lys Ile Glu Asp His Leu Leu Ser Ser Gly Lys Phe Met 
385                 390                 395                 400 


Tyr Leu Glu Gly Asn Ala Asp Ser Ala Met Ser 
                405                 410     


<210>  5995
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  5995

Met Ala Thr Ala Ala Gln Gly Pro Leu Ser Leu Leu Trp Gly Trp Leu 
1               5                   10                  15      


Trp Ser Glu Arg Phe Trp Leu Pro Glu Asn Val Ser Trp Ala Asp Leu 
            20                  25                  30          


Glu Gly Pro Ala Asp Gly Tyr Gly Tyr Pro Arg Gly Arg His Ile Leu 
        35                  40                  45              


Ser Val Phe Pro Leu Ala Ala Gly Ile Phe Phe Val Arg Leu Leu Phe 
    50                  55                  60                  


Glu Arg Phe Ile Ala Lys Pro Cys Ala Leu Cys Ile Gly Ile Glu Asp 
65                  70                  75                  80  


Ser Gly Pro Tyr Gln Ala Gln Pro Asn Ala Ile Leu Glu Lys Val Phe 
                85                  90                  95      


Ile Ser Ile Thr Lys Tyr Pro Asp Lys Lys Arg Leu Glu Gly Leu Ser 
            100                 105                 110         


Lys Gln Leu Asp Trp Asn Val Arg Lys Ile Gln Cys Trp Phe Arg His 
        115                 120                 125             


Arg Arg Asn Gln Asp Lys Pro Pro Thr Leu Thr Lys Phe Cys Glu Ser 
    130                 135                 140                 


Met Trp Arg Phe Thr Phe Tyr Leu Cys Ile Phe Cys Tyr Gly Ile Arg 
145                 150                 155                 160 


Phe Leu Trp Ser Ser Pro Trp Phe Trp Asp Ile Arg Gln Cys Trp His 
                165                 170                 175     


Asn Tyr Pro Phe Gln Pro Leu Ser Ser Gly Leu Tyr His Tyr Tyr Ile 
            180                 185                 190         


Met Glu Leu Ala Phe Tyr Trp Ser Leu Met Phe Ser Gln Phe Thr Asp 
        195                 200                 205             


Ile Lys Arg Lys Asp Phe Leu Ile Met Phe Val His His Leu Val Thr 
    210                 215                 220                 


Ile Gly Leu Ile Ser Phe Ser Tyr Ile Asn Asn Met Val Arg Val Gly 
225                 230                 235                 240 


Thr Leu Ile Met Cys Leu His Asp Val Ser Asp Phe Leu Leu Glu Ala 
                245                 250                 255     


Ala Lys Leu Ala Asn Tyr Ala Lys Tyr Gln Arg Leu Cys Asp Thr Leu 
            260                 265                 270         


Phe Val Ile Phe Ser Ala Val Phe Met Val Thr Arg Leu Gly Ile Tyr 
        275                 280                 285             


Pro Phe Trp Ile Leu Asn Thr Thr Leu Phe Glu Ser Trp Glu Ile Ile 
    290                 295                 300                 


Gly Pro Tyr Ala Ser Trp Trp Leu Leu Asn Gly Leu Leu Leu Thr Leu 
305                 310                 315                 320 


Gln Leu Leu His Val Ile Trp Ser Tyr Leu Ile Ala Arg Ile Ala Leu 
                325                 330                 335     


Lys Ala Leu Ile Arg Gly Lys Val Ser Lys Asp Asp Arg Ser Asp Val 
            340                 345                 350         


Glu Ser Ser Ser Glu Glu Glu Asp Val Thr Thr Cys Thr Lys Ser Pro 
        355                 360                 365             


Cys Asp Ser Ser Ser Ser Asn Gly Ala Asn Arg Val Asn Gly His Met 
    370                 375                 380                 


Gly Gly Ser Tyr Trp Ala Glu Glu 
385                 390         


<210>  5996
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  5996

Met Ala Gly Trp Pro Gly Ala Gly Pro Leu Cys Val Leu Gly Gly Ala 
1               5                   10                  15      


Ala Leu Gly Val Cys Leu Ala Gly Val Ala Gly Gln Leu Val Glu Pro 
            20                  25                  30          


Ser Thr Ala Pro Pro Lys Pro Lys Pro Pro Pro Leu Thr Lys Glu Thr 
        35                  40                  45              


Val Val Phe Trp Asp Met Arg Leu Trp His Val Val Gly Ile Phe Ser 
    50                  55                  60                  


Leu Phe Val Leu Ser Ile Ile Ile Thr Leu Cys Cys Val Phe Asn Cys 
65                  70                  75                  80  


Arg Val Pro Arg Thr Arg Lys Glu Ile Glu Ala Arg Tyr Leu Gln Arg 
                85                  90                  95      


Lys Ala Ala Lys Met Tyr Thr Asp Lys Leu Glu Thr Val Pro Pro Leu 
            100                 105                 110         


Asn Glu Leu Thr Glu Val Pro Gly Glu Asp Lys Lys Lys Lys Lys Lys 
        115                 120                 125             


Lys Lys Lys Asp Ser Val Asp Thr Val Ala Ile Lys Val Glu Glu Asp 
    130                 135                 140                 


Glu Lys Asn Glu Ala Lys Lys Lys Lys Gly Glu Lys 
145                 150                 155     


<210>  5997
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  5997

Met Val Ser Leu Met Lys Leu Trp Ile Pro Met Leu Met Thr Phe Phe 
1               5                   10                  15      


Cys Thr Val Leu Leu Ser Val Leu Gly Glu Met Arg Lys Lys Arg Tyr 
            20                  25                  30          


Asp Arg Lys Glu Leu Leu Leu Glu Glu Cys Trp Gly Lys Pro Asn Val 
        35                  40                  45              


Lys Glu Cys Thr Asn Lys Cys Ser Lys Ala Phe Arg Cys Lys Asp Lys 
    50                  55                  60                  


Asn Tyr Thr Cys Cys Trp Thr Tyr Cys Gly Asn Ile Cys Trp Ile Asn 
65                  70                  75                  80  


Val Glu Thr Ser Gly Asp Tyr 
                85          


<210>  5998
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  5998

Met Lys Pro Trp Ile Leu Leu Leu Val Met Phe Ile Ser Gly Val Val 
1               5                   10                  15      


Met Leu Leu Pro Val Leu Gly Ser Phe Trp Asn Lys Asp Pro Phe Leu 
            20                  25                  30          


Asp Met Ile Arg Glu Thr Glu Gln Cys Trp Val Gln Pro Pro Tyr Lys 
        35                  40                  45              


Tyr Cys Glu Lys Arg Cys Thr Lys Ile Met Thr Cys Val Arg Pro Asn 
    50                  55                  60                  


His Thr Cys Cys Trp Thr Tyr Cys Gly Asn Ile Cys Leu Asp Asn Glu 
65                  70                  75                  80  


Glu Pro Leu Lys Ser Met Leu Asn Pro 
                85                  


<210>  5999
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  5999

Met Asp Pro Thr Ile Ser Thr Leu Asp Thr Glu Leu Thr Pro Ile Asn 
1               5                   10                  15      


Gly Thr Glu Glu Thr Leu Cys Tyr Lys Gln Thr Leu Ser Leu Thr Val 
            20                  25                  30          


Leu Thr Cys Ile Val Ser Leu Val Gly Leu Thr Gly Asn Ala Val Val 
        35                  40                  45              


Leu Trp Leu Leu Gly Cys Arg Met Arg Arg Asn Ala Phe Ser Ile Tyr 
    50                  55                  60                  


Ile Leu Asn Leu Ala Ala Ala Asp Phe Leu Phe Leu Ser Gly Arg Leu 
65                  70                  75                  80  


Ile Tyr Ser Leu Leu Ser Phe Ile Ser Ile Pro His Thr Ile Ser Lys 
                85                  90                  95      


Ile Leu Tyr Pro Val Met Met Phe Ser Tyr Phe Ala Gly Leu Ser Phe 
            100                 105                 110         


Leu Ser Ala Val Ser Thr Glu Arg Cys Leu Ser Val Leu Trp Pro Ile 
        115                 120                 125             


Trp Tyr Arg Cys His Arg Pro Thr His Leu Ser Ala Val Val Cys Val 
    130                 135                 140                 


Leu Leu Trp Ala Leu Ser Leu Leu Arg Ser Ile Leu Glu Trp Met Leu 
145                 150                 155                 160 


Cys Gly Phe Leu Phe Ser Gly Ala Asp Ser Ala Trp Cys Gln Thr Ser 
                165                 170                 175     


Asp Phe Ile Thr Val Ala Trp Leu Ile Phe Leu Cys Val Val Leu Cys 
            180                 185                 190         


Gly Ser Ser Leu Val Leu Leu Ile Arg Ile Leu Cys Gly Ser Arg Lys 
        195                 200                 205             


Ile Pro Leu Thr Arg Leu Tyr Val Thr Ile Leu Leu Thr Val Leu Val 
    210                 215                 220                 


Phe Leu Leu Cys Gly Leu Pro Phe Gly Ile Gln Phe Phe Leu Phe Leu 
225                 230                 235                 240 


Trp Ile His Val Asp Arg Glu Val Leu Phe Cys His Val His Leu Val 
                245                 250                 255     


Ser Ile Phe Leu Ser Ala Leu Asn Ser Ser Ala Asn Pro Ile Ile Tyr 
            260                 265                 270         


Phe Phe Val Gly Ser Phe Arg Gln Arg Gln Asn Arg Gln Asn Leu Lys 
        275                 280                 285             


Leu Val Leu Gln Arg Ala Leu Gln Asp Ala Ser Glu Val Asp Glu Gly 
    290                 295                 300                 


Gly Gly Gln Leu Pro Glu Glu Ile Leu Glu Leu Ser Gly Ser Arg Leu 
305                 310                 315                 320 


Glu Gln 
        


<210>  6000
<211>  811
<212>  PRT
<213>  Homo sapiens

<400>  6000

Met Ala Asp Ser Ser Glu Gly Pro Arg Ala Gly Pro Gly Glu Val Ala 
1               5                   10                  15      


Glu Leu Pro Gly Asp Glu Ser Gly Thr Pro Gly Gly Glu Ala Phe Pro 
            20                  25                  30          


Leu Ser Ser Leu Ala Asn Leu Phe Glu Gly Glu Asp Gly Ser Leu Ser 
        35                  40                  45              


Pro Ser Pro Ala Asp Ala Ser Arg Pro Ala Gly Pro Gly Asp Gly Arg 
    50                  55                  60                  


Pro Asn Leu Arg Met Lys Phe Gln Gly Ala Phe Arg Lys Gly Val Pro 
65                  70                  75                  80  


Asn Pro Ile Asp Leu Leu Glu Ser Thr Leu Tyr Glu Ser Ser Val Val 
                85                  90                  95      


Pro Gly Pro Lys Lys Ala Pro Met Asp Ser Leu Phe Asp Tyr Gly Thr 
            100                 105                 110         


Tyr Arg His His Ser Ser Asp Asn Lys Arg Trp Arg Lys Lys Ile Ile 
        115                 120                 125             


Glu Lys Gln Pro Gln Ser Pro Lys Ala Pro Ala Pro Gln Pro Pro Pro 
    130                 135                 140                 


Ile Leu Lys Val Phe Asn Arg Pro Ile Leu Phe Asp Ile Val Ser Arg 
145                 150                 155                 160 


Gly Ser Thr Ala Asp Leu Asp Gly Leu Leu Pro Phe Leu Leu Thr His 
                165                 170                 175     


Lys Lys Arg Leu Thr Asp Glu Glu Phe Arg Glu Pro Ser Thr Gly Lys 
            180                 185                 190         


Thr Cys Leu Pro Lys Ala Leu Leu Asn Leu Ser Asn Gly Arg Asn Asp 
        195                 200                 205             


Thr Ile Pro Val Leu Leu Asp Ile Ala Glu Arg Thr Gly Asn Met Arg 
    210                 215                 220                 


Glu Phe Ile Asn Ser Pro Phe Arg Asp Ile Tyr Tyr Arg Gly Gln Thr 
225                 230                 235                 240 


Ala Leu His Ile Ala Ile Glu Arg Arg Cys Lys His Tyr Val Glu Leu 
                245                 250                 255     


Leu Val Ala Gln Gly Ala Asp Val His Ala Gln Ala Arg Gly Arg Phe 
            260                 265                 270         


Phe Gln Pro Lys Asp Glu Gly Gly Tyr Phe Tyr Phe Gly Glu Leu Pro 
        275                 280                 285             


Leu Ser Leu Ala Ala Cys Thr Asn Gln Pro His Ile Val Asn Tyr Leu 
    290                 295                 300                 


Thr Glu Asn Pro His Lys Lys Ala Asp Met Arg Arg Gln Asp Ser Arg 
305                 310                 315                 320 


Gly Asn Thr Val Leu His Ala Leu Val Ala Ile Ala Asp Asn Thr Arg 
                325                 330                 335     


Glu Asn Thr Lys Phe Val Thr Lys Met Tyr Asp Leu Leu Leu Leu Lys 
            340                 345                 350         


Cys Ala Arg Leu Phe Pro Asp Ser Asn Leu Glu Ala Val Leu Asn Asn 
        355                 360                 365             


Asp Gly Leu Ser Pro Leu Met Met Ala Ala Lys Thr Gly Lys Ile Gly 
    370                 375                 380                 


Asn Arg His Glu Met Leu Ala Val Glu Pro Ile Asn Glu Leu Leu Arg 
385                 390                 395                 400 


Asp Lys Trp Arg Lys Phe Gly Ala Val Ser Phe Tyr Ile Asn Val Val 
                405                 410                 415     


Ser Tyr Leu Cys Ala Met Val Ile Phe Thr Leu Thr Ala Tyr Tyr Gln 
            420                 425                 430         


Pro Leu Glu Gly Thr Pro Pro Tyr Pro Tyr Arg Thr Thr Val Asp Tyr 
        435                 440                 445             


Leu Arg Leu Ala Gly Glu Val Ile Thr Leu Phe Thr Gly Val Leu Phe 
    450                 455                 460                 


Phe Phe Thr Asn Ile Lys Asp Leu Phe Met Lys Lys Cys Pro Gly Val 
465                 470                 475                 480 


Asn Ser Leu Phe Ile Asp Gly Ser Phe Gln Leu Leu Tyr Phe Ile Tyr 
                485                 490                 495     


Ser Val Leu Val Ile Val Ser Ala Ala Leu Tyr Leu Ala Gly Ile Glu 
            500                 505                 510         


Ala Tyr Leu Ala Val Met Val Phe Ala Leu Val Leu Gly Trp Met Asn 
        515                 520                 525             


Ala Leu Tyr Phe Thr Arg Gly Leu Lys Leu Thr Gly Thr Tyr Ser Ile 
    530                 535                 540                 


Met Ile Gln Lys Ile Leu Phe Lys Asp Leu Phe Arg Phe Leu Leu Val 
545                 550                 555                 560 


Tyr Leu Leu Phe Met Ile Gly Tyr Ala Ser Ala Leu Val Ser Leu Leu 
                565                 570                 575     


Asn Pro Cys Ala Asn Met Lys Val Cys Asn Glu Asp Gln Thr Asn Cys 
            580                 585                 590         


Thr Val Pro Thr Tyr Pro Ser Cys Arg Asp Ser Glu Thr Phe Ser Thr 
        595                 600                 605             


Phe Leu Leu Asp Leu Phe Lys Leu Thr Ile Gly Met Gly Asp Leu Glu 
    610                 615                 620                 


Met Leu Ser Ser Thr Lys Tyr Pro Val Val Phe Ile Ile Leu Leu Val 
625                 630                 635                 640 


Thr Tyr Ile Ile Leu Thr Phe Val Leu Leu Leu Asn Met Leu Ile Ala 
                645                 650                 655     


Leu Met Gly Glu Thr Val Gly Gln Val Ser Lys Glu Ser Lys His Ile 
            660                 665                 670         


Trp Lys Leu Gln Trp Ala Thr Thr Ile Leu Asp Ile Glu Arg Ser Phe 
        675                 680                 685             


Pro Val Phe Leu Arg Lys Ala Phe Arg Ser Gly Glu Met Val Thr Val 
    690                 695                 700                 


Gly Lys Ser Ser Asp Gly Thr Pro Asp Arg Arg Trp Cys Phe Arg Val 
705                 710                 715                 720 


Asp Glu Val Asn Trp Ser His Trp Asn Gln Asn Leu Gly Ile Ile Asn 
                725                 730                 735     


Glu Asp Pro Gly Lys Asn Glu Thr Tyr Gln Tyr Tyr Gly Phe Ser His 
            740                 745                 750         


Thr Val Gly Arg Leu Arg Arg Asp Arg Trp Ser Ser Val Val Pro Arg 
        755                 760                 765             


Val Val Glu Leu Asn Lys Asn Ser Asn Pro Asp Glu Val Val Val Pro 
    770                 775                 780                 


Leu Asp Ser Met Gly Asn Pro Arg Cys Asp Gly His Gln Gln Gly Tyr 
785                 790                 795                 800 


Pro Arg Lys Trp Arg Thr Asp Asp Ala Pro Leu 
                805                 810     


<210>  6001
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  6001

Met Lys Arg Ser Gly Asn Pro Gly Ala Glu Val Thr Asn Ser Ser Val 
1               5                   10                  15      


Ala Gly Pro Asp Cys Cys Gly Gly Leu Gly Asn Ile Asp Phe Arg Gln 
            20                  25                  30          


Ala Asp Phe Cys Val Met Thr Arg Leu Leu Gly Tyr Val Asp Pro Leu 
        35                  40                  45              


Asp Pro Ser Phe Val Ala Ala Val Ile Thr Ile Thr Phe Asn Pro Leu 
    50                  55                  60                  


Tyr Trp Asn Val Val Ala Arg Trp Glu His Lys Thr Arg Lys Leu Ser 
65                  70                  75                  80  


Arg Ala Phe Gly Ser Pro Tyr Leu Ala Cys Tyr Ser Leu Ser Val Thr 
                85                  90                  95      


Ile Leu Leu Leu Asn Phe Leu Arg Ser His Cys Phe Thr Gln Ala Met 
            100                 105                 110         


Leu Ser Gln Pro Arg Met Glu Ser Leu Asp Thr Pro Ala Ala Tyr Ser 
        115                 120                 125             


Leu Gly Leu Ala Leu Leu Gly Leu Gly Val Val Leu Val Leu Ser Ser 
    130                 135                 140                 


Phe Phe Ala Leu Gly Phe Ala Gly Thr Phe Leu Gly Asp Tyr Phe Gly 
145                 150                 155                 160 


Ile Leu Lys Glu Ala Arg Val Thr Val Phe Pro Phe Asn Ile Leu Asp 
                165                 170                 175     


Asn Pro Met Tyr Trp Gly Ser Thr Ala Asn Tyr Leu Gly Trp Ala Ile 
            180                 185                 190         


Met His Ala Ser Pro Thr Gly Leu Leu Leu Thr Val Leu Val Ala Leu 
        195                 200                 205             


Thr Tyr Ile Val Ala Leu Leu Tyr Glu Glu Pro Phe Thr Ala Glu Ile 
    210                 215                 220                 


Tyr Arg Gln Lys Ala Ser Gly Ser His Lys Arg Ser 
225                 230                 235     


<210>  6002
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  6002

Met Thr Arg Leu Leu Gly Tyr Val Asp Pro Leu Asp Pro Ser Phe Val 
1               5                   10                  15      


Ala Ala Val Ile Thr Ile Thr Phe Asn Pro Leu Tyr Trp Asn Val Val 
            20                  25                  30          


Ala Arg Trp Glu His Lys Thr Arg Lys Leu Ser Arg Ala Phe Gly Ser 
        35                  40                  45              


Pro Tyr Leu Ala Cys Tyr Ser Leu Ser Val Thr Ile Leu Leu Leu Asn 
    50                  55                  60                  


Phe Leu Arg Ser His Cys Phe Thr Gln Ala Met Leu Ser Gln Pro Arg 
65                  70                  75                  80  


Met Glu Ser Leu Asp Thr Pro Ala Ala Tyr Ser Leu Gly Leu Ala Leu 
                85                  90                  95      


Leu Gly Leu Gly Val Val Leu Val Leu Ser Ser Phe Phe Ala Leu Gly 
            100                 105                 110         


Phe Ala Gly Thr Phe Leu Gly Asp Tyr Phe Gly Ile Leu Lys Glu Ala 
        115                 120                 125             


Arg Val Thr Val Phe Pro Phe Asn Ile Leu Asp Asn Pro Met Tyr Trp 
    130                 135                 140                 


Gly Ser Thr Ala Asn Tyr Leu Gly Trp Ala Ile Met His Ala Ser Pro 
145                 150                 155                 160 


Thr Gly Leu Leu Leu Thr Val Leu Val Ala Leu Thr Tyr Ile Val Ala 
                165                 170                 175     


Leu Leu Tyr Glu Glu Pro Phe Thr Ala Glu Ile Tyr Arg Gln Lys Ala 
            180                 185                 190         


Ser Gly Ser His Lys Arg Ser 
        195                 


<210>  6003
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  6003

Met Gly Leu Ser Pro Asn Leu Asp Arg Gln Thr Met Ala Glu Phe Ser 
1               5                   10                  15      


Gln Lys Arg Gly Lys Arg Arg Ser Asp Glu Gly Leu Gly Ser Met Val 
            20                  25                  30          


Asp Phe Leu Leu Ala Asn Ala Arg Leu Val Leu Gly Val Gly Gly Ala 
        35                  40                  45              


Ala Val Leu Gly Ile Ala Thr Leu Ala Val Lys Arg Phe Ile Asp Arg 
    50                  55                  60                  


Ala Thr Ser Pro Arg Asp Glu Asp Asp Thr Lys Ala Asp Ser Trp Lys 
65                  70                  75                  80  


Glu Leu Ser Leu Leu Lys Ala Thr Pro His Leu Gln Pro Arg Pro Pro 
                85                  90                  95      


Pro Ala Ala Leu Ser Gln Pro Val Leu Pro Leu Ala Pro Ser Ser Ser 
            100                 105                 110         


Ala Pro Glu Gly Pro Ala Glu Thr Asp Pro Glu Val Thr Pro Gln Leu 
        115                 120                 125             


Ser Ser Pro Ala Pro Leu Cys Leu Thr Leu Gln Glu Arg Leu Leu Ala 
    130                 135                 140                 


Phe Glu Arg Asp Arg Val Thr Ile Pro Ala Ala Gln Val Ala Leu Ala 
145                 150                 155                 160 


Lys Gln Leu Ala Gly Asp Ile Ala Leu Glu Leu Gln Ala Tyr Phe Arg 
                165                 170                 175     


Ser Lys Phe Pro Glu Leu Pro Phe Gly Ala Phe Val Pro Gly Gly Pro 
            180                 185                 190         


Leu Tyr Asp Gly Leu Gln Ala Gly Ala Ala Asp His Val Arg Leu Leu 
        195                 200                 205             


Val Pro Leu Val Leu Glu Pro Gly Leu Trp Ser Leu Val Pro Gly Val 
    210                 215                 220                 


Asp Thr Val Ala Arg Asp Pro Arg Cys Trp Ala Val Arg Arg Thr Gln 
225                 230                 235                 240 


Leu Glu Phe Cys Pro Arg Gly Ser Ser Pro Trp Asp Arg Phe Leu Val 
                245                 250                 255     


Gly Gly Tyr Leu Ser Ser Arg Val Leu Leu Glu Leu Leu Arg Lys Ala 
            260                 265                 270         


Leu Ala Ala Ser Val Asn Trp Pro Ala Ile Gly Ser Leu Leu Gly Cys 
        275                 280                 285             


Leu Ile Arg Pro Ser Met Ala Ser Glu Glu Leu Leu Leu Glu Val Gln 
    290                 295                 300                 


His Glu Arg Leu Glu Leu Thr Val Ala Val Leu Val Ala Val Pro Gly 
305                 310                 315                 320 


Val Asp Ala Asp Asp Arg Leu Leu Leu Ala Trp Pro Leu Glu Gly Leu 
                325                 330                 335     


Ala Gly Asn Leu Trp Leu Gln Asp Leu Tyr Pro Val Glu Ala Ala Arg 
            340                 345                 350         


Leu Arg Ala Leu Asp Asp His Asp Ala Gly Thr Arg Arg Arg Leu Leu 
        355                 360                 365             


Leu Leu Leu Cys Ala Val Cys Arg Gly Cys Ser Ala Leu Gly Gln Leu 
    370                 375                 380                 


Gly Arg Gly His Leu Thr Gln Val Val Leu Arg Leu Gly Glu Asp Asn 
385                 390                 395                 400 


Val Asp Trp Thr Glu Glu Ala Leu Gly Glu Arg Phe Leu Gln Ala Leu 
                405                 410                 415     


Glu Leu Leu Ile Gly Ser Leu Glu Gln Ala Ser Leu Pro Cys His Phe 
            420                 425                 430         


Asn Pro Ser Val Asn Leu Phe Ser Ser Leu Arg Glu Glu Glu Ile Asp 
        435                 440                 445             


Asp Ile Gly Tyr Ala Leu Tyr Ser Gly Leu Gln Glu Pro Glu Gly Leu 
    450                 455                 460                 


Leu 
465 


<210>  6004
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  6004

Met Ala Arg Ser Ala Thr Leu Ala Ala Ala Ala Leu Ala Leu Cys Leu 
1               5                   10                  15      


Leu Leu Ala Pro Pro Gly Leu Ala Trp Tyr Lys Pro Ala Ala Gly His 
            20                  25                  30          


Ser Ser Tyr Ser Val Gly Arg Ala Ala Gly Leu Leu Ser Gly Leu Arg 
        35                  40                  45              


Arg Ser Pro Tyr Ala Arg Arg Ser Gln Pro Tyr Arg Gly Ala Glu Pro 
    50                  55                  60                  


Pro Gly Gly Ala Gly Ala Ser Pro Glu Leu Gln Leu His Pro Arg Leu 
65                  70                  75                  80  


Arg Ser Leu Ala Val Cys Val Gln Asp Val Ala Pro Asn Leu Gln Arg 
                85                  90                  95      


Cys Glu Arg Leu Pro Asp Gly Arg Gly Thr Tyr Gln Cys Lys Ala Asn 
            100                 105                 110         


Val Phe Leu Ser Leu Arg Ala Ala Asp Cys Leu Ala Ala 
        115                 120                 125 


<210>  6005
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  6005

Met Ala Gln His Gly Ala Met Gly Ala Phe Arg Ala Leu Cys Gly Leu 
1               5                   10                  15      


Ala Leu Leu Cys Ala Leu Ser Leu Gly Gln Arg Pro Thr Gly Gly Pro 
            20                  25                  30          


Gly Cys Gly Pro Gly Arg Leu Leu Leu Gly Thr Gly Thr Asp Ala Arg 
        35                  40                  45              


Cys Cys Arg Val His Thr Thr Arg Cys Cys Arg Asp Tyr Pro Gly Glu 
    50                  55                  60                  


Glu Cys Cys Ser Glu Trp Asp Cys Met Cys Val Gln Pro Glu Phe His 
65                  70                  75                  80  


Cys Gly Asp Pro Cys Cys Thr Thr Cys Arg His His Pro Cys Pro Pro 
                85                  90                  95      


Gly Gln Gly Val Gln Ser Gln Gly Lys Phe Ser Phe Gly Phe Gln Cys 
            100                 105                 110         


Ile Asp Cys Ala Ser Gly Thr Phe Ser Gly Gly His Glu Gly His Cys 
        115                 120                 125             


Lys Pro Trp Thr Asp Cys Cys Trp Arg Cys Arg Arg Arg Pro Lys Thr 
    130                 135                 140                 


Pro Glu Ala Ala Ser Ser Pro Arg Lys Ser Gly Ala Ser Asp Arg Gln 
145                 150                 155                 160 


Arg Arg Arg Gly Gly Trp Glu Thr Cys Gly Cys Glu Pro Gly Arg Pro 
                165                 170                 175     


Pro Gly Pro Pro Thr Ala Ala Ser Pro Ser Pro Gly Ala Pro Gln Ala 
            180                 185                 190         


Ala Gly Ala Leu Arg Ser Ala Leu Gly Arg Ala Leu Leu Pro Trp Gln 
        195                 200                 205             


Gln Lys Trp Val Gln Glu Gly Gly Ser Asp Gln Arg Pro Gly Pro Cys 
    210                 215                 220                 


Ser Ser Ala Ala Ala Ala Gly Pro Cys Arg Arg Glu Arg Glu Thr Gln 
225                 230                 235                 240 


Ser Trp Pro Pro Ser Ser Leu Ala Gly Pro Asp Gly Val Gly Ser 
                245                 250                 255 


<210>  6006
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  6006

Met Ala Gln His Gly Ala Met Gly Ala Phe Arg Ala Leu Cys Gly Leu 
1               5                   10                  15      


Ala Leu Leu Cys Ala Leu Ser Leu Gly Gln Arg Pro Thr Gly Gly Pro 
            20                  25                  30          


Gly Cys Gly Pro Gly Arg Leu Leu Leu Gly Thr Gly Thr Asp Ala Arg 
        35                  40                  45              


Cys Cys Arg Val His Thr Thr Arg Cys Cys Arg Asp Tyr Pro Gly Glu 
    50                  55                  60                  


Glu Cys Cys Ser Glu Trp Asp Cys Met Cys Val Gln Pro Glu Phe His 
65                  70                  75                  80  


Cys Gly Asp Pro Cys Cys Thr Thr Cys Arg His His Pro Cys Pro Pro 
                85                  90                  95      


Gly Gln Gly Val Gln Ser Gln Gly Lys Phe Ser Phe Gly Phe Gln Cys 
            100                 105                 110         


Ile Asp Cys Ala Ser Gly Thr Phe Ser Gly Gly His Glu Gly His Cys 
        115                 120                 125             


Lys Pro Trp Thr Asp Cys Thr Gln Phe Gly Phe Leu Thr Val Phe Pro 
    130                 135                 140                 


Gly Asn Lys Thr His Asn Ala Val Cys Val Pro Gly Ser Pro Pro Ala 
145                 150                 155                 160 


Glu Pro Leu Gly Trp Leu Thr Val Val Leu Leu Ala Val Ala Ala Cys 
                165                 170                 175     


Val Leu Leu Leu Thr Ser Ala Gln Leu Gly Leu His Ile Trp Gln Leu 
            180                 185                 190         


Arg Lys Thr Gln Leu Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala 
        195                 200                 205             


Arg Ser Cys Gln Phe Pro Glu Glu Glu Arg Gly Glu Arg Ser Ala Glu 
    210                 215                 220                 


Glu Lys Gly Arg Leu Gly Asp Leu Trp Val 
225                 230                 


<210>  6007
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  6007

Met Val Leu Lys Ala Phe Phe Pro Thr Cys Cys Val Ser Thr Asp Ser 
1               5                   10                  15      


Gly Leu Leu Val Gly Arg Trp Val Pro Glu Gln Ser Ser Ala Val Val 
            20                  25                  30          


Leu Ala Val Leu His Phe Pro Phe Ile Pro Ile Gln Val Lys Gln Leu 
        35                  40                  45              


Leu Ala Gln Val Arg Gln Ala Ser Gln Val Gly Val Ala Val Leu Gly 
    50                  55                  60                  


Thr Trp Cys His Cys Arg Gln Glu Pro Glu Glu Ser Leu Gly Arg Phe 
65                  70                  75                  80  


Leu Glu Ser Leu Gly Ala Val Phe Pro His Glu Pro Trp Leu Arg Leu 
                85                  90                  95      


Cys Arg Glu Arg Gly Gly Thr Phe Trp Ser Cys Glu Ala Thr His Arg 
            100                 105                 110         


Gln Ala Pro Thr Ala Pro Gly Ala Pro Gly Glu Asp Gln Val Met Leu 
        115                 120                 125             


Ile Phe Tyr Asp Gln Arg Gln Val Leu Leu Ser Gln Leu His Leu Pro 
    130                 135                 140                 


Thr Val Leu Pro Asp Arg Gln Ala Gly Ala Thr Thr Ala Ser Thr Gly 
145                 150                 155                 160 


Gly Leu Ala Ala Val Phe Asp Thr Val Ala Arg Ser Glu Val Leu Phe 
                165                 170                 175     


Arg Ser Asp Arg Phe Asp Glu Gly Pro Val Arg Leu Ser His Trp Gln 
            180                 185                 190         


Ser Glu Gly Val Glu Ala Ser Ile Leu Ala Glu Leu Ala Arg Arg Ala 
        195                 200                 205             


Ser Gly Pro Ile Cys Leu Leu Leu Ala Ser Leu Leu Ser Leu Val Ser 
    210                 215                 220                 


Ala Val Ser Ala Cys Arg Val Phe Lys Leu Trp Pro Leu Ser Phe Leu 
225                 230                 235                 240 


Gly Ser Lys Leu Ser Thr Cys Glu Gln Leu Arg His Arg Leu Glu His 
                245                 250                 255     


Leu Thr Leu Ile Phe Ser Thr Arg Lys Ala Glu Asn Pro Ala Gln Leu 
            260                 265                 270         


Met Arg Lys Ala Asn Thr Val Ala Ser Val Leu Leu Asp Val Ala Leu 
        275                 280                 285             


Gly Leu Met Leu Leu Ser Trp Leu His Gly Arg Ser Arg Ile Gly His 
    290                 295                 300                 


Leu Ala Asp Ala Leu Val Pro Val Ala Asp His Val Ala Glu Glu Leu 
305                 310                 315                 320 


Gln His Leu Leu Gln Trp Leu Met Gly Ala Pro Ala Gly Leu Lys Met 
                325                 330                 335     


Asn Arg Ala Leu Asp Gln Val Leu Gly Arg Phe Phe Leu Tyr His Ile 
            340                 345                 350         


His Leu Trp Ile Ser Tyr Ile His Leu Met Ser Pro Phe Val Glu His 
        355                 360                 365             


Ile Leu Trp His Val Gly Leu Ser Ala Cys Leu Gly Leu Thr Val Ala 
    370                 375                 380                 


Leu Ser Leu Leu Ser Asp Ile Ile Ala Leu Leu Thr Phe His Ile Tyr 
385                 390                 395                 400 


Cys Phe Tyr Val Tyr Gly Ala Arg Leu Tyr Cys Leu Lys Ile His Gly 
                405                 410                 415     


Leu Ser Ser Leu Trp Arg Leu Phe Arg Gly Lys Lys Trp Asn Val Leu 
            420                 425                 430         


Arg Gln Arg Val Asp Ser Cys Ser Tyr Asp Leu Asp Gln Leu Phe Ile 
        435                 440                 445             


Gly Thr Leu Leu Phe Thr Ile Leu Leu Phe Leu Leu Pro Thr Thr Ala 
    450                 455                 460                 


Leu Tyr Tyr Leu Val Phe Thr Leu Leu Arg Leu Leu Val Val Ala Val 
465                 470                 475                 480 


Gln Gly Leu Ile His Leu Leu Val Asp Leu Ile Asn Ser Leu Pro Leu 
                485                 490                 495     


Tyr Ser Leu Gly Leu Arg Leu Cys Arg Pro Tyr Arg Leu Ala Asp Lys 
            500                 505                 510         


Pro Thr Ala Leu Gln Pro Arg Gly Ala His Leu Pro Pro Pro Gln Leu 
        515                 520                 525             


Trp Leu Pro Pro Gln Ala Leu Leu Gly Arg Pro Val Pro Gln Ala Val 
    530                 535                 540                 


Pro Trp Gly Ala His Leu Pro Leu Glu Ala Glu Arg Gly Gln Ala Gly 
545                 550                 555                 560 


Leu Arg Glu Leu Leu Ala Arg Leu Ala Pro Pro His Gly His Ser Gln 
                565                 570                 575     


Pro Ser Ala Leu Pro Gly Trp His Gln Leu Ser Trp Arg Met Ser Cys 
            580                 585                 590         


Ala Leu Trp Thr Leu Leu Cys Ala Pro Glu His Gly Arg Pro Cys Tyr 
        595                 600                 605             


His Thr Leu Gly Leu Glu Val Ile Gly Ser Glu Gln Met Trp Gly Trp 
    610                 615                 620                 


Pro Ala Arg Leu Ala Ala Leu His His Trp His Cys Leu Pro Trp Asp 
625                 630                 635                 640 


Pro Leu Pro Thr Cys Cys Gly His His Gly Gly Glu His Ser Asn Pro 
                645                 650                 655     


Arg Cys Pro Glu His Cys Pro Met Pro Thr Leu Cys Thr Gln Val Gln 
            660                 665                 670         


Arg Val Arg Pro Pro Gln Gln Pro Gln Val Glu Gly Trp Ser Pro Trp 
        675                 680                 685             


Gly Leu Pro Ser Gly Ser Ala Leu Ala Val Gly Val Glu Gly Pro Cys 
    690                 695                 700                 


Gln Asp Glu Pro Pro Ser Pro Arg His Pro Leu Ala Pro Ser Ala Glu 
705                 710                 715                 720 


Gln His Pro Ala Ser Gly Gly Leu Lys Gln Ser Leu Thr Pro Val Pro 
                725                 730                 735     


Ser Gly Pro Gly Pro Ser Leu Pro Glu Pro His Gly Val Tyr Leu Arg 
            740                 745                 750         


Met Phe Pro Gly Glu Val Ala Leu 
        755                 760 


<210>  6008
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  6008

Met Ala Glu Gln Ser Asp Glu Ala Val Lys Tyr Tyr Thr Leu Glu Glu 
1               5                   10                  15      


Ile Gln Lys His Asn His Ser Lys Ser Thr Trp Leu Ile Leu His His 
            20                  25                  30          


Lys Val Tyr Asp Leu Thr Lys Phe Leu Glu Glu His Pro Gly Gly Glu 
        35                  40                  45              


Glu Val Leu Arg Glu Gln Ala Gly Gly Asp Ala Thr Glu Asn Phe Glu 
    50                  55                  60                  


Asp Val Gly His Ser Thr Asp Ala Arg Glu Met Ser Lys Thr Phe Ile 
65                  70                  75                  80  


Ile Gly Glu Leu His Pro Asp Asp Arg Pro Lys Leu Asn Lys Pro Pro 
                85                  90                  95      


Glu Thr Leu Ile Thr Thr Ile Asp Ser Ser Ser Ser Trp Trp Thr Asn 
            100                 105                 110         


Trp Val Ile Pro Ala Ile Ser Ala Val Ala Val Ala Leu Met Tyr Arg 
        115                 120                 125             


Leu Tyr Met Ala Glu Asp 
    130                 


<210>  6009
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  6009

Met Ala Leu Lys Val Leu Leu Glu Gln Glu Lys Thr Phe Phe Thr Leu 
1               5                   10                  15      


Leu Val Leu Leu Gly Tyr Leu Ser Cys Lys Val Thr Cys Glu Ser Gly 
            20                  25                  30          


Asp Cys Arg Gln Gln Glu Phe Arg Asp Arg Ser Gly Asn Cys Val Pro 
        35                  40                  45              


Cys Asn Gln Cys Gly Pro Gly Met Glu Leu Ser Lys Glu Cys Gly Phe 
    50                  55                  60                  


Gly Tyr Gly Glu Asp Ala Gln Cys Val Thr Cys Arg Leu His Arg Phe 
65                  70                  75                  80  


Lys Glu Asp Trp Gly Phe Gln Lys Cys Lys Pro Cys Leu Asp Cys Ala 
                85                  90                  95      


Val Val Asn Arg Phe Gln Lys Ala Asn Cys Ser Ala Thr Ser Asp Ala 
            100                 105                 110         


Ile Cys Gly Asp Cys Leu Pro Gly Phe Tyr Arg Lys Thr Lys Leu Val 
        115                 120                 125             


Gly Phe Gln Asp Met Glu Cys Val Pro Cys Gly Asp Pro Pro Pro Pro 
    130                 135                 140                 


Tyr Glu Pro His Cys Ala Ser Lys Val Asn Leu Val Lys Ile Ala Ser 
145                 150                 155                 160 


Thr Ala Ser Ser Pro Arg Asp Thr Ala Leu Ala Ala Val Ile Cys Ser 
                165                 170                 175     


Ala Leu Ala Thr Val Leu Leu Ala Leu Leu Ile Leu Cys Val Ile Tyr 
            180                 185                 190         


Cys Lys Arg Gln Phe Met Glu Lys Lys Pro Ser Trp Ser Leu Arg Ser 
        195                 200                 205             


Gln Asp Ile Gln Tyr Asn Gly Ser Glu Leu Ser Cys Phe Asp Arg Pro 
    210                 215                 220                 


Gln Leu His Glu Tyr Ala His Arg Ala Cys Cys Gln Cys Arg Arg Asp 
225                 230                 235                 240 


Ser Val Gln Thr Cys Gly Pro Val Arg Leu Leu Pro Ser Met Cys Cys 
                245                 250                 255     


Glu Glu Ala Cys Ser Pro Asn Pro Ala Thr Leu Gly Cys Gly Val His 
            260                 265                 270         


Ser Ala Ala Ser Leu Gln Ala Arg Asn Ala Gly Pro Ala Gly Glu Met 
        275                 280                 285             


Val Pro Thr Phe Phe Gly Ser Leu Thr Gln Ser Ile Cys Gly Glu Phe 
    290                 295                 300                 


Ser Asp Ala Trp Pro Leu Met Gln Asn Pro Met Gly Gly Asp Asn Ile 
305                 310                 315                 320 


Ser Phe Cys Asp Ser Tyr Pro Glu Leu Thr Gly Glu Asp Ile His Ser 
                325                 330                 335     


Leu Asn Pro Glu Leu Glu Ser Ser Thr Ser Leu Asp Ser Asn Ser Ser 
            340                 345                 350         


Gln Asp Leu Val Gly Gly Ala Val Pro Val Gln Ser His Ser Glu Asn 
        355                 360                 365             


Phe Thr Ala Ala Thr Asp Leu Ser Arg Tyr Asn Asn Thr Leu Val Glu 
    370                 375                 380                 


Ser Ala Ser Thr Gln Asp Ala Leu Thr Met Arg Ser Gln Leu Asp Gln 
385                 390                 395                 400 


Glu Ser Gly Ala Val Ile His Pro Ala Thr Gln Thr Ser Leu Gln Glu 
                405                 410                 415     


Ala 
    


<210>  6010
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  6010

Met Ala Asn Ser Gly Leu Gln Leu Leu Gly Tyr Phe Leu Ala Leu Gly 
1               5                   10                  15      


Gly Trp Val Gly Ile Ile Ala Ser Thr Ala Leu Pro Gln Trp Lys Gln 
            20                  25                  30          


Ser Ser Tyr Ala Gly Asp Ala Ile Ile Thr Ala Val Gly Leu Tyr Glu 
        35                  40                  45              


Gly Leu Trp Met Ser Cys Ala Ser Gln Ser Thr Gly Gln Val Gln Cys 
    50                  55                  60                  


Lys Leu Tyr Asp Ser Leu Leu Ala Leu Asp Gly His Ile Gln Ser Ala 
65                  70                  75                  80  


Arg Ala Leu Met Val Val Ala Val Leu Leu Gly Phe Val Ala Met Val 
                85                  90                  95      


Leu Ser Val Val Gly Met Lys Cys Thr Arg Val Gly Asp Ser Asn Pro 
            100                 105                 110         


Ile Ala Lys Gly Arg Val Ala Ile Ala Gly Gly Ala Leu Phe Ile Leu 
        115                 120                 125             


Ala Gly Leu Cys Thr Leu Thr Ala Val Ser Trp Tyr Ala Thr Leu Val 
    130                 135                 140                 


Thr Gln Glu Phe Phe Asn Pro Ser Thr Pro Val Asn Ala Arg Tyr Glu 
145                 150                 155                 160 


Phe Gly Pro Ala Leu Phe Val Gly Trp Ala Ser Ala Gly Leu Ala Val 
                165                 170                 175     


Leu Gly Gly Ser Phe Leu Cys Cys Thr Cys Pro Glu Pro Glu Arg Pro 
            180                 185                 190         


Asn Ser Ser Pro Gln Pro Tyr Arg Pro Gly Pro Ser Ala Ala Ala Arg 
        195                 200                 205             


Glu Pro Val Val Lys Leu Pro Ala Ser Ala Lys Gly Pro Leu Gly Val 
    210                 215                 220                 


<210>  6011
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  6011

Met Leu Cys His Arg Gly Gly Gln Leu Ile Val Pro Ile Ile Pro Leu 
1               5                   10                  15      


Cys Pro Glu His Ser Cys Arg Gly Arg Arg Leu Gln Asn Leu Leu Ser 
            20                  25                  30          


Gly Pro Trp Pro Lys Gln Pro Met Glu Leu His Asn Leu Ser Ser Pro 
        35                  40                  45              


Ser Pro Ser Leu Ser Ser Ser Val Leu Pro Pro Ser Phe Ser Pro Ser 
    50                  55                  60                  


Pro Ser Ser Ala Pro Ser Ala Phe Thr Thr Val Gly Gly Ser Ser Gly 
65                  70                  75                  80  


Gly Pro Cys His Pro Thr Ser Ser Ser Leu Val Ser Ala Phe Leu Ala 
                85                  90                  95      


Pro Ile Leu Ala Leu Glu Phe Val Leu Gly Leu Val Gly Asn Ser Leu 
            100                 105                 110         


Ala Leu Phe Ile Phe Cys Ile His Thr Arg Pro Trp Thr Ser Asn Thr 
        115                 120                 125             


Val Phe Leu Val Ser Leu Val Ala Ala Asp Phe Leu Leu Ile Ser Asn 
    130                 135                 140                 


Leu Pro Leu Arg Val Asp Tyr Tyr Leu Leu His Glu Thr Trp Arg Phe 
145                 150                 155                 160 


Gly Ala Ala Ala Cys Lys Val Asn Leu Phe Met Leu Ser Thr Asn Arg 
                165                 170                 175     


Thr Ala Ser Val Val Phe Leu Thr Ala Ile Ala Leu Asn Arg Tyr Leu 
            180                 185                 190         


Lys Val Val Gln Pro His His Val Leu Ser Arg Ala Ser Val Gly Ala 
        195                 200                 205             


Ala Ala Arg Val Ala Gly Gly Leu Trp Val Gly Ile Leu Leu Leu Asn 
    210                 215                 220                 


Gly His Leu Leu Leu Ser Thr Phe Ser Gly Pro Ser Cys Leu Ser Tyr 
225                 230                 235                 240 


Arg Val Gly Thr Lys Pro Ser Ala Ser Leu Arg Trp His Gln Ala Leu 
                245                 250                 255     


Tyr Leu Leu Glu Phe Phe Leu Pro Leu Ala Leu Ile Leu Phe Ala Ile 
            260                 265                 270         


Val Ser Ile Gly Leu Thr Ile Arg Asn Arg Gly Leu Gly Gly Gln Ala 
        275                 280                 285             


Gly Pro Gln Arg Ala Met Arg Val Leu Ala Met Val Val Ala Val Tyr 
    290                 295                 300                 


Thr Ile Cys Phe Leu Pro Ser Ile Ile Phe Gly Met Ala Ser Met Val 
305                 310                 315                 320 


Ala Phe Trp Leu Ser Ala Cys Arg Ser Leu Asp Leu Cys Thr Gln Leu 
                325                 330                 335     


Phe His Gly Ser Leu Ala Phe Thr Tyr Leu Asn Ser Val Leu Asp Pro 
            340                 345                 350         


Val Leu Tyr Cys Phe Ser Ser Pro Asn Phe Leu His Gln Ser Arg Ala 
        355                 360                 365             


Leu Leu Gly Leu Thr Arg Gly Arg Gln Gly Pro Val Ser Asp Glu Ser 
    370                 375                 380                 


Ser Tyr Gln Pro Ser Arg Gln Trp Arg Tyr Arg Glu Ala Ser Arg Lys 
385                 390                 395                 400 


Ala Glu Ala Ile Gly Lys Leu Lys Val Gln Gly Glu Val Ser Leu Glu 
                405                 410                 415     


Lys Glu Gly Ser Ser Gln Gly 
            420             


<210>  6012
<211>  926
<212>  PRT
<213>  Homo sapiens

<400>  6012

Met Ala Phe Leu Ile Ile Leu Ile Thr Cys Phe Val Ile Ile Leu Ala 
1               5                   10                  15      


Thr Ser Gln Pro Cys Gln Thr Pro Asp Asp Phe Val Ala Ala Thr Ser 
            20                  25                  30          


Pro Gly His Ile Ile Ile Gly Gly Leu Phe Ala Ile His Glu Lys Met 
        35                  40                  45              


Leu Ser Ser Glu Asp Ser Pro Arg Arg Pro Gln Ile Gln Glu Cys Val 
    50                  55                  60                  


Gly Phe Glu Ile Ser Val Phe Leu Gln Thr Leu Ala Met Ile His Ser 
65                  70                  75                  80  


Ile Glu Met Ile Asn Asn Ser Thr Leu Leu Pro Gly Val Lys Leu Gly 
                85                  90                  95      


Tyr Glu Ile Tyr Asp Thr Cys Thr Glu Val Thr Val Ala Met Ala Ala 
            100                 105                 110         


Thr Leu Arg Phe Leu Ser Lys Phe Asn Cys Ser Arg Glu Thr Val Glu 
        115                 120                 125             


Phe Lys Cys Asp Tyr Ser Ser Tyr Met Pro Arg Val Lys Ala Val Ile 
    130                 135                 140                 


Gly Ser Gly Tyr Ser Glu Ile Thr Met Ala Val Ser Arg Met Leu Asn 
145                 150                 155                 160 


Leu Gln Leu Met Pro Gln Val Gly Tyr Glu Ser Thr Ala Glu Ile Leu 
                165                 170                 175     


Ser Asp Lys Ile Arg Phe Pro Ser Phe Leu Arg Thr Val Pro Ser Asp 
            180                 185                 190         


Phe His Gln Ile Lys Ala Met Ala His Leu Ile Gln Lys Ser Gly Trp 
        195                 200                 205             


Asn Trp Ile Gly Ile Ile Thr Thr Asp Asp Asp Tyr Gly Arg Leu Ala 
    210                 215                 220                 


Leu Asn Thr Phe Ile Ile Gln Ala Glu Ala Asn Asn Val Cys Ile Ala 
225                 230                 235                 240 


Phe Lys Glu Val Leu Pro Ala Phe Leu Ser Asp Asn Thr Ile Glu Val 
                245                 250                 255     


Arg Ile Asn Arg Thr Leu Lys Lys Ile Ile Leu Glu Ala Gln Val Asn 
            260                 265                 270         


Val Ile Val Val Phe Leu Arg Gln Phe His Val Phe Asp Leu Phe Asn 
        275                 280                 285             


Lys Ala Ile Glu Met Asn Ile Asn Lys Met Trp Ile Ala Ser Asp Asn 
    290                 295                 300                 


Trp Ser Thr Ala Thr Lys Ile Thr Thr Ile Pro Asn Val Lys Lys Ile 
305                 310                 315                 320 


Gly Lys Val Val Gly Phe Ala Phe Arg Arg Gly Asn Ile Ser Ser Phe 
                325                 330                 335     


His Ser Phe Leu Gln Asn Leu His Leu Leu Pro Ser Asp Ser His Lys 
            340                 345                 350         


Leu Leu His Glu Tyr Ala Met His Leu Ser Ala Cys Ala Tyr Val Lys 
        355                 360                 365             


Asp Thr Asp Leu Ser Gln Cys Ile Phe Asn His Ser Gln Arg Thr Leu 
    370                 375                 380                 


Ala Tyr Lys Ala Asn Lys Ala Ile Glu Arg Asn Phe Val Met Arg Asn 
385                 390                 395                 400 


Asp Phe Leu Trp Asp Tyr Ala Glu Pro Gly Leu Ile His Ser Ile Gln 
                405                 410                 415     


Leu Ala Val Phe Ala Leu Gly Tyr Ala Ile Arg Asp Leu Cys Gln Ala 
            420                 425                 430         


Arg Asp Cys Gln Asn Pro Asn Ala Phe Gln Pro Trp Glu Leu Leu Gly 
        435                 440                 445             


Val Leu Lys Asn Val Thr Phe Thr Asp Gly Trp Asn Ser Phe His Phe 
    450                 455                 460                 


Asp Ala His Gly Asp Leu Asn Thr Gly Tyr Asp Val Val Leu Trp Lys 
465                 470                 475                 480 


Glu Ile Asn Gly His Met Thr Val Thr Lys Met Ala Glu Tyr Asp Leu 
                485                 490                 495     


Gln Asn Asp Val Phe Ile Ile Pro Asp Gln Glu Thr Lys Asn Glu Phe 
            500                 505                 510         


Arg Asn Leu Lys Gln Ile Gln Ser Lys Cys Ser Lys Glu Cys Ser Pro 
        515                 520                 525             


Gly Gln Met Lys Lys Thr Thr Arg Ser Gln His Ile Cys Cys Tyr Glu 
    530                 535                 540                 


Cys Gln Asn Cys Pro Glu Asn His Tyr Thr Asn Gln Thr Asp Met Pro 
545                 550                 555                 560 


His Cys Leu Leu Cys Asn Asn Lys Thr His Trp Ala Pro Val Arg Ser 
                565                 570                 575     


Thr Met Cys Phe Glu Lys Glu Val Glu Tyr Leu Asn Trp Asn Asp Ser 
            580                 585                 590         


Leu Ala Ile Leu Leu Leu Ile Leu Ser Leu Leu Gly Ile Ile Phe Val 
        595                 600                 605             


Leu Val Val Gly Ile Ile Phe Thr Arg Asn Leu Asn Thr Pro Val Val 
    610                 615                 620                 


Lys Ser Ser Gly Gly Leu Arg Val Cys Tyr Val Ile Leu Leu Cys His 
625                 630                 635                 640 


Phe Leu Asn Phe Ala Ser Thr Ser Phe Phe Ile Gly Glu Pro Gln Asp 
                645                 650                 655     


Phe Thr Cys Lys Thr Arg Gln Thr Met Phe Gly Val Ser Phe Thr Leu 
            660                 665                 670         


Cys Ile Ser Cys Ile Leu Thr Lys Ser Leu Lys Ile Leu Leu Ala Phe 
        675                 680                 685             


Ser Phe Asp Pro Lys Leu Gln Lys Phe Leu Lys Cys Leu Tyr Arg Pro 
    690                 695                 700                 


Ile Leu Ile Ile Phe Thr Cys Thr Gly Ile Gln Val Val Ile Cys Thr 
705                 710                 715                 720 


Leu Trp Leu Ile Phe Ala Ala Pro Thr Val Glu Val Asn Val Ser Leu 
                725                 730                 735     


Pro Arg Val Ile Ile Leu Glu Cys Glu Glu Gly Ser Ile Leu Ala Phe 
            740                 745                 750         


Gly Thr Met Leu Gly Tyr Ile Ala Ile Leu Ala Phe Ile Cys Phe Ile 
        755                 760                 765             


Phe Ala Phe Lys Gly Lys Tyr Glu Asn Tyr Asn Glu Ala Lys Phe Ile 
    770                 775                 780                 


Thr Phe Gly Met Leu Ile Tyr Phe Ile Ala Trp Ile Thr Phe Ile Pro 
785                 790                 795                 800 


Ile Tyr Ala Thr Thr Phe Gly Lys Tyr Val Pro Ala Val Glu Ile Ile 
                805                 810                 815     


Val Ile Leu Ile Ser Asn Tyr Gly Ile Leu Tyr Cys Thr Phe Ile Pro 
            820                 825                 830         


Lys Cys Tyr Val Ile Ile Cys Lys Gln Glu Ile Asn Thr Lys Ser Ala 
        835                 840                 845             


Phe Leu Lys Met Ile Tyr Ser Tyr Ser Ser His Ser Val Ser Ser Ile 
    850                 855                 860                 


Ala Leu Ser Pro Ala Ser Leu Asp Ser Met Ser Gly Asn Val Thr Met 
865                 870                 875                 880 


Thr Asn Pro Ser Ser Ser Gly Lys Ser Ala Thr Trp Gln Lys Ser Lys 
                885                 890                 895     


Asp Leu Gln Ala Gln Ala Phe Ala His Ile Cys Arg Glu Asn Ala Thr 
            900                 905                 910         


Ser Val Ser Lys Thr Leu Pro Arg Lys Arg Met Ser Ser Ile 
        915                 920                 925     


<210>  6013
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  6013

Met Glu Gln Arg Pro Arg Gly Cys Ala Ala Val Ala Ala Ala Leu Leu 
1               5                   10                  15      


Leu Val Leu Leu Gly Ala Arg Ala Gln Gly Gly Thr Arg Ser Pro Arg 
            20                  25                  30          


Cys Asp Cys Ala Gly Asp Phe His Lys Lys Ile Gly Leu Phe Cys Cys 
        35                  40                  45              


Arg Gly Cys Pro Ala Gly His Tyr Leu Lys Ala Pro Cys Thr Glu Pro 
    50                  55                  60                  


Cys Gly Asn Ser Thr Cys Leu Val Cys Pro Gln Asp Thr Phe Leu Ala 
65                  70                  75                  80  


Trp Glu Asn His His Asn Ser Glu Cys Ala Arg Cys Gln Ala Cys Asp 
                85                  90                  95      


Glu Gln Ala Ser Gln Val Ala Leu Glu Asn Cys Ser Ala Val Ala Asp 
            100                 105                 110         


Thr Arg Cys Gly Cys Lys Pro Gly Trp Phe Val Glu Cys Gln Val Ser 
        115                 120                 125             


Gln Cys Val Ser Ser Ser Pro Phe Tyr Cys Gln Pro Cys Leu Asp Cys 
    130                 135                 140                 


Gly Ala Leu His Arg His Thr Arg Leu Leu Cys Ser Arg Arg Asp Thr 
145                 150                 155                 160 


Asp Cys Gly Thr Cys Leu Pro Gly Phe Tyr Glu His Gly Asp Gly Cys 
                165                 170                 175     


Val Ser Cys Pro Thr Pro Pro Pro Ser Leu Ala Gly Ala Pro Trp Gly 
            180                 185                 190         


Ala Val Gln Ser Ala Val Pro Leu Ser Val Ala Gly Gly Arg Val Gly 
        195                 200                 205             


Val Phe Trp Val Gln Val Leu Leu Ala Gly Leu Val Val Pro Leu Leu 
    210                 215                 220                 


Leu Gly Ala Thr Leu Thr Tyr Thr Tyr Arg His Cys Trp Pro His Lys 
225                 230                 235                 240 


Pro Leu Val Thr Ala Asp Glu Ala Gly Met Glu Ala Leu Thr Pro Pro 
                245                 250                 255     


Pro Ala Thr His Leu Ser Pro Leu Asp Ser Ala His Thr Leu Leu Ala 
            260                 265                 270         


Pro Pro Asp Ser Ser Glu Lys Ile Cys Thr Val Gln Leu Val Gly Asn 
        275                 280                 285             


Ser Trp Thr Pro Gly Tyr Pro Glu Thr Gln Glu Ala Leu Cys Pro Gln 
    290                 295                 300                 


Val Thr Trp Ser Trp Asp Gln Leu Pro Ser Arg Ala Leu Gly Pro Ala 
305                 310                 315                 320 


Ala Ala Pro Thr Leu Ser Pro Glu Ser Pro Ala Gly Ser Pro Ala Met 
                325                 330                 335     


Met Leu Gln Pro Gly Pro Gln Leu Tyr Asp Val Met Asp Ala Val Pro 
            340                 345                 350         


Ala Arg Arg Trp Lys Glu Phe Val Arg Thr Leu Gly Leu Arg Glu Ala 
        355                 360                 365             


Glu Ile Glu Ala Val Glu Val Glu Ile Gly Arg Phe Arg Asp Gln Gln 
    370                 375                 380                 


Tyr Glu Met Leu Lys Arg Trp Arg Gln Gln Gln Pro Ala Gly Leu Gly 
385                 390                 395                 400 


Ala Val Tyr Ala Ala Leu Glu Arg Met Gly Leu Asp Gly Cys Val Glu 
                405                 410                 415     


Asp Leu Arg Ser Arg Leu Gln Arg Gly Pro 
            420                 425     


<210>  6014
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  6014

Met Glu Gln Arg Pro Arg Gly Cys Ala Ala Val Ala Ala Ala Leu Leu 
1               5                   10                  15      


Leu Val Leu Leu Gly Ala Arg Ala Gln Gly Gly Thr Arg Ser Pro Arg 
            20                  25                  30          


Cys Asp Cys Ala Gly Asp Phe His Lys Lys Ile Gly Leu Phe Cys Cys 
        35                  40                  45              


Arg Gly Cys Pro Ala Gly His Tyr Leu Lys Ala Pro Cys Thr Glu Pro 
    50                  55                  60                  


Cys Gly Asn Ser Thr Cys Leu Val Cys Pro Gln Asp Thr Phe Leu Ala 
65                  70                  75                  80  


Trp Glu Asn His His Asn Ser Glu Cys Ala Arg Cys Gln Ala Cys Asp 
                85                  90                  95      


Glu Gln Ala Ser Gln Val Ala Leu Glu Asn Cys Ser Ala Val Ala Asp 
            100                 105                 110         


Thr Arg Cys Gly Cys Lys Pro Gly Trp Phe Val Glu Cys Gln Val Ser 
        115                 120                 125             


Gln Cys Val Ser Ser Ser Pro Phe Tyr Cys Gln Pro Cys Leu Asp Cys 
    130                 135                 140                 


Gly Ala Leu His Arg His Thr Arg Leu Leu Cys Ser Arg Arg Asp Thr 
145                 150                 155                 160 


Asp Cys Gly Thr Cys Leu Pro Gly Phe Tyr Glu His Gly Asp Gly Cys 
                165                 170                 175     


Val Ser Cys Pro Thr Ser Thr Leu Gly Ser Cys Pro Glu Arg Cys Ala 
            180                 185                 190         


Ala Val Cys Gly Trp Arg Gln Asn Glu Ala Gly Met Glu Ala Leu Thr 
        195                 200                 205             


Pro Pro Pro Ala Thr His Leu Ser Pro Leu Asp Ser Ala His Thr Leu 
    210                 215                 220                 


Leu Ala Pro Pro Asp Ser Ser Glu Lys Ile Cys Thr Val Gln Leu Val 
225                 230                 235                 240 


Gly Asn Ser Trp Thr Pro Gly Tyr Pro Glu Thr Gln Glu Ala Leu Cys 
                245                 250                 255     


Pro Gln Val Thr Trp Ser Trp Asp Gln Leu Pro Ser Arg Ala Leu Gly 
            260                 265                 270         


Pro Ala Ala Ala Pro Thr Leu Ser Pro Glu Ser Pro Ala Gly Ser Pro 
        275                 280                 285             


Ala Met Met Leu Gln Pro Gly Pro Gln Leu Tyr Asp Val Met Asp Ala 
    290                 295                 300                 


Val Pro Ala Arg Arg Trp Lys Glu Phe Val Arg Thr Leu Gly Leu Arg 
305                 310                 315                 320 


Glu Ala Glu Ile Glu Ala Val Glu Val Glu Ile Gly Arg Phe Arg Asp 
                325                 330                 335     


Gln Gln Tyr Glu Met Leu Lys Arg Trp Arg Gln Gln Gln Pro Ala Gly 
            340                 345                 350         


Leu Gly Ala Val Tyr Ala Ala Leu Glu Arg Met Gly Leu Asp Gly Cys 
        355                 360                 365             


Val Glu Asp Leu Arg Ser Arg Leu Gln Arg Gly Pro 
    370                 375                 380 


<210>  6015
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  6015

Met Glu Gln Arg Pro Arg Gly Cys Ala Ala Val Ala Ala Ala Leu Leu 
1               5                   10                  15      


Leu Val Leu Leu Gly Ala Arg Ala Gln Gly Gly Thr Arg Ser Pro Arg 
            20                  25                  30          


Cys Asp Cys Ala Gly Asp Phe His Lys Lys Ile Gly Leu Phe Cys Cys 
        35                  40                  45              


Arg Gly Cys Pro Ala Ala Ser Gln Val Ala Leu Glu Asn Cys Ser Ala 
    50                  55                  60                  


Val Ala Asp Thr Arg Cys Gly Cys Lys Pro Gly Trp Phe Val Glu Cys 
65                  70                  75                  80  


Gln Val Ser Gln Cys Val Ser Ser Ser Pro Phe Tyr Cys Gln Pro Cys 
                85                  90                  95      


Leu Asp Cys Gly Ala Leu His Arg His Thr Arg Leu Leu Cys Ser Arg 
            100                 105                 110         


Arg Asp Thr Asp Cys Gly Thr Cys Leu Pro Gly Phe Tyr Glu His Gly 
        115                 120                 125             


Asp Gly Cys Val Ser Cys Pro Thr Ser Thr Leu Gly Ser Cys Pro Glu 
    130                 135                 140                 


Arg Cys Ala Ala Val Cys Gly Trp Arg Gln Met Phe Trp Val Gln Val 
145                 150                 155                 160 


Leu Leu Ala Gly Leu Val Val Pro Leu Leu Leu Gly Ala Thr Leu Thr 
                165                 170                 175     


Tyr Thr Tyr Arg His Cys Trp Pro His Lys Pro Leu Val Thr Ala Asp 
            180                 185                 190         


Glu Ala Gly Met Glu Ala Leu Thr Pro Pro Pro Ala Thr His Leu Ser 
        195                 200                 205             


Pro Leu Asp Ser Ala His Thr Leu Leu Ala Pro Pro Asp Ser Ser Glu 
    210                 215                 220                 


Lys Ile Cys Thr Val Gln Leu Val Gly Asn Ser Trp Thr Pro Gly Tyr 
225                 230                 235                 240 


Pro Glu Thr Gln Glu Ala Leu Cys Pro Gln Val Thr Trp Ser Trp Asp 
                245                 250                 255     


Gln Leu Pro Ser Arg Ala Leu Gly Pro Ala Ala Ala Pro Thr Leu Ser 
            260                 265                 270         


Pro Glu Ser Pro Ala Gly Ser Pro Ala Met Met Leu Gln Pro Gly Pro 
        275                 280                 285             


Gln Leu Tyr Asp Val Met Asp Ala Val Pro Ala Arg Arg Trp Lys Glu 
    290                 295                 300                 


Phe Val Arg Thr Leu Gly Leu Arg Glu Ala Glu Ile Glu Ala Val Glu 
305                 310                 315                 320 


Val Glu Ile Gly Arg Phe Arg Asp Gln Gln Tyr Glu Met Leu Lys Arg 
                325                 330                 335     


Trp Arg Gln Gln Gln Pro Ala Gly Leu Gly Ala Val Tyr Ala Ala Leu 
            340                 345                 350         


Glu Arg Met Gly Leu Asp Gly Cys Val Glu Asp Leu Arg Ser Arg Leu 
        355                 360                 365             


Gln Arg Gly Pro 
    370         


<210>  6016
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  6016

Met Glu Gln Arg Pro Arg Gly Cys Ala Ala Val Ala Ala Ala Leu Leu 
1               5                   10                  15      


Leu Val Leu Leu Gly Ala Arg Ala Gln Gly Gly Thr Arg Ser Pro Arg 
            20                  25                  30          


Cys Asp Cys Ala Gly Asp Phe His Lys Lys Ile Gly Leu Phe Cys Cys 
        35                  40                  45              


Arg Gly Cys Pro Ala Asp Glu Ala Gly Met Glu Ala Leu Thr Pro Pro 
    50                  55                  60                  


Pro Ala Thr His Leu Ser Pro Leu Asp Ser Ala His Thr Leu Leu Ala 
65                  70                  75                  80  


Pro Pro Asp Ser Ser Glu Lys Ile Cys Thr Val Gln Leu Val Gly Asn 
                85                  90                  95      


Ser Trp Thr Pro Gly Tyr Pro Glu Thr Gln Glu Ala Leu Cys Pro Gln 
            100                 105                 110         


Val Thr Trp Ser Trp Asp Gln Leu Pro Ser Arg Ala Leu Gly Pro Ala 
        115                 120                 125             


Ala Ala Pro Thr Leu Ser Pro Glu Ser Pro Ala Gly Ser Pro Ala Met 
    130                 135                 140                 


Met Leu Gln Pro Gly Pro Gln Leu Tyr Asp Val Met Asp Ala Val Pro 
145                 150                 155                 160 


Ala Arg Arg Trp Lys Glu Phe Val Arg Thr Leu Gly Leu Arg Glu Ala 
                165                 170                 175     


Glu Ile Glu Ala Val Glu Val Glu Ile Gly Arg Phe Arg Asp Gln Gln 
            180                 185                 190         


Tyr Glu Met Leu Lys Arg Trp Arg Gln Gln Gln Pro Ala Gly Leu Gly 
        195                 200                 205             


Ala Val Tyr Ala Ala Leu Glu Arg Met Gly Leu Asp Gly Cys Val Glu 
    210                 215                 220                 


Asp Leu Arg Ser Arg Leu Gln Arg Gly Pro 
225                 230                 


<210>  6017
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  6017

Met His Gln Thr Tyr Ser Arg His Cys Arg Pro Glu Glu Ser Thr Phe 
1               5                   10                  15      


Ser Ala Ala Met Thr Thr Met Gln Gly Met Glu Gln Ala Met Pro Gly 
            20                  25                  30          


Ala Gly Pro Gly Val Pro Gln Leu Gly Asn Met Ala Val Ile His Ser 
        35                  40                  45              


His Leu Trp Lys Gly Leu Gln Glu Lys Phe Leu Lys Gly Glu Pro Lys 
    50                  55                  60                  


Val Leu Gly Val Val Gln Ile Leu Thr Ala Leu Met Ser Leu Ser Met 
65                  70                  75                  80  


Gly Ile Thr Met Met Cys Met Ala Ser Asn Thr Tyr Gly Ser Asn Pro 
                85                  90                  95      


Ile Ser Val Tyr Ile Gly Tyr Thr Ile Trp Gly Ser Val Met Phe Ile 
            100                 105                 110         


Ile Ser Gly Ser Leu Ser Ile Ala Ala Gly Ile Arg Thr Thr Lys Gly 
        115                 120                 125             


Leu Val Arg Gly Ser Leu Gly Met Asn Ile Thr Ser Ser Val Leu Ala 
    130                 135                 140                 


Ala Ser Gly Ile Leu Ile Asn Thr Phe Ser Leu Ala Phe Tyr Ser Phe 
145                 150                 155                 160 


His His Pro Tyr Cys Asn Tyr Tyr Gly Asn Ser Asn Asn Cys His Gly 
                165                 170                 175     


Thr Met Ser Ile Leu Met Gly Leu Asp Gly Met Val Leu Leu Leu Ser 
            180                 185                 190         


Val Leu Glu Phe Cys Ile Ala Val Ser Leu Ser Ala Phe Gly Cys Lys 
        195                 200                 205             


Val Leu Cys Cys Thr Pro Gly Gly Val Val Leu Ile Leu Pro Ser His 
    210                 215                 220                 


Ser His Met Ala Glu Thr Ala Ser Pro Thr Pro Leu Asn Glu Val 
225                 230                 235                 


<210>  6018
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  6018

Met Gly Glu Trp Ala Phe Leu Gly Ser Leu Leu Asp Ala Val Gln Leu 
1               5                   10                  15      


Gln Ser Pro Leu Val Gly Arg Leu Trp Leu Val Val Met Leu Ile Phe 
            20                  25                  30          


Arg Ile Leu Val Leu Ala Thr Val Gly Gly Ala Val Phe Glu Asp Glu 
        35                  40                  45              


Gln Glu Glu Phe Val Cys Asn Thr Leu Gln Pro Gly Cys Arg Gln Thr 
    50                  55                  60                  


Cys Tyr Asp Arg Ala Phe Pro Val Ser His Tyr Arg Phe Trp Leu Phe 
65                  70                  75                  80  


His Ile Leu Leu Leu Ser Ala Pro Pro Val Leu Phe Val Val Tyr Ser 
                85                  90                  95      


Met His Arg Ala Gly Lys Glu Ala Gly Gly Ala Glu Ala Ala Ala Gln 
            100                 105                 110         


Cys Ala Pro Gly Leu Pro Glu Ala Gln Cys Ala Pro Cys Ala Leu Arg 
        115                 120                 125             


Ala Arg Arg Ala Arg Arg Cys Tyr Leu Leu Ser Val Ala Leu Arg Leu 
    130                 135                 140                 


Leu Ala Glu Leu Thr Phe Leu Gly Gly Gln Ala Leu Leu Tyr Gly Phe 
145                 150                 155                 160 


Arg Val Ala Pro His Phe Ala Cys Ala Gly Pro Pro Cys Pro His Thr 
                165                 170                 175     


Val Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr Val Phe Val Leu 
            180                 185                 190         


Phe Tyr Phe Ala Val Gly Leu Leu Ser Ala Leu Leu Ser Val Ala Glu 
        195                 200                 205             


Leu Gly His Leu Leu Trp Lys Gly Arg Pro Arg Ala Gly Glu Arg Asp 
    210                 215                 220                 


Asn Arg Cys Asn Arg Ala His Glu Glu Ala Gln Lys Leu Leu Pro Pro 
225                 230                 235                 240 


Pro Pro Pro Pro Pro Pro Pro Pro Ala Leu Pro Ser Arg Arg Pro Gly 
                245                 250                 255     


Pro Glu Pro Cys Ala Pro Pro Ala Tyr Ala His Pro Ala Pro Ala Ser 
            260                 265                 270         


Leu Arg Glu Cys Gly Ser Gly Arg Gly Lys Ala Ser Pro Ala Thr Gly 
        275                 280                 285             


Arg Arg Asp Leu Ala Ile 
    290                 


<210>  6019
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  6019

Met Lys Pro Ser Leu Leu Cys Arg Pro Leu Ser Cys Phe Leu Met Leu 
1               5                   10                  15      


Leu Pro Trp Pro Leu Ala Thr Leu Thr Ser Thr Thr Leu Trp Gln Cys 
            20                  25                  30          


Pro Pro Gly Glu Glu Pro Asp Leu Asp Pro Gly Gln Gly Thr Leu Cys 
        35                  40                  45              


Arg Pro Cys Pro Pro Gly Thr Phe Ser Ala Ala Trp Gly Ser Ser Pro 
    50                  55                  60                  


Cys Gln Pro His Ala Arg Cys Ser Leu Trp Arg Arg Leu Glu Ala Gln 
65                  70                  75                  80  


Val Gly Met Ala Thr Arg Asp Thr Leu Cys Gly Asp Cys Trp Pro Gly 
                85                  90                  95      


Trp Phe Gly Pro Trp Gly Val Pro Arg Val Pro Cys Gln Pro Cys Ser 
            100                 105                 110         


Trp Ala Pro Leu Gly Thr His Gly Cys Asp Glu Trp Gly Arg Arg Ala 
        115                 120                 125             


Arg Arg Gly Val Glu Val Ala Ala Gly Ala Ser Ser Gly Gly Glu Thr 
    130                 135                 140                 


Arg Gln Pro Gly Asn Gly Thr Arg Ala Gly Gly Pro Glu Glu Thr Ala 
145                 150                 155                 160 


Ala Gln Tyr Ala Val Ile Ala Ile Val Pro Val Phe Cys Leu Met Gly 
                165                 170                 175     


Leu Leu Gly Ile Leu Val Cys Asn Leu Leu Lys Arg Lys Gly Tyr His 
            180                 185                 190         


Cys Thr Ala His Lys Glu Val Gly Pro Gly Pro Gly Gly Gly Gly Ser 
        195                 200                 205             


Gly Ile Asn Pro Ala Tyr Arg Thr Glu Asp Ala Asn Glu Asp Thr Ile 
    210                 215                 220                 


Gly Val Leu Val Arg Leu Ile Thr Glu Lys Lys Glu Asn Ala Ala Ala 
225                 230                 235                 240 


Leu Glu Glu Leu Leu Lys Glu Tyr His Ser Lys Gln Leu Val Gln Thr 
                245                 250                 255     


Ser His Arg Pro Val Ser Lys Leu Pro Pro Ala Pro Pro Asn Val Pro 
            260                 265                 270         


His Ile Cys Pro His Arg His His Leu His Thr Val Gln Gly Leu Ala 
        275                 280                 285             


Ser Leu Ser Gly Pro Cys Cys Ser Arg Cys Ser Gln Lys Lys Trp Pro 
    290                 295                 300                 


Glu Val Leu Leu Ser Pro Glu Ala Val Ala Ala Thr Thr Pro Val Pro 
305                 310                 315                 320 


Ser Leu Leu Pro Asn Pro Thr Arg Val Pro Lys Ala Gly Ala Lys Ala 
                325                 330                 335     


Gly Arg Gln Gly Glu Ile Thr Ile Leu Ser Val Gly Arg Phe Arg Val 
            340                 345                 350         


Ala Arg Ile Pro Glu Gln Arg Thr Ser Ser Met Val Ser Glu Val Lys 
        355                 360                 365             


Thr Ile Thr Glu Ala Gly Pro Ser Trp Gly Asp Leu Pro Asp Ser Pro 
    370                 375                 380                 


Gln Pro Gly Leu Pro Pro Glu Gln Gln Ala Leu Leu Gly Ser Gly Gly 
385                 390                 395                 400 


Ser Arg Thr Lys Trp Leu Lys Pro Pro Ala Glu Asn Lys Ala Glu Glu 
                405                 410                 415     


Asn Arg Tyr Val Val Arg Leu Ser Glu Ser Asn Leu Val Ile 
            420                 425                 430 


<210>  6020
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  6020

Met Gly Pro Arg Ala Lys Thr Ile Ser Ser Leu Phe Phe Leu Leu Trp 
1               5                   10                  15      


Val Leu Ala Glu Pro Ala Glu Asn Ser Asp Phe Tyr Leu Pro Gly Asp 
            20                  25                  30          


Tyr Leu Leu Gly Gly Leu Phe Ser Leu His Ala Asn Met Lys Gly Ile 
        35                  40                  45              


Val His Leu Asn Phe Leu Gln Val Pro Met Cys Lys Glu Tyr Glu Val 
    50                  55                  60                  


Lys Val Ile Gly Tyr Asn Leu Met Gln Ala Met Arg Phe Ala Val Glu 
65                  70                  75                  80  


Glu Ile Asn Asn Asp Ser Ser Leu Leu Pro Gly Val Leu Leu Gly Tyr 
                85                  90                  95      


Glu Ile Val Asp Val Cys Tyr Ile Ser Asn Asn Val Gln Pro Val Leu 
            100                 105                 110         


Tyr Phe Leu Ala His Glu Asp Asn Leu Leu Pro Ile Gln Glu Asp Tyr 
        115                 120                 125             


Ser Asn Tyr Ile Ser Arg Val Val Ala Val Ile Gly Pro Asp Asn Ser 
    130                 135                 140                 


Glu Ser Val Met Thr Val Ala Asn Phe Leu Ser Leu Phe Leu Leu Pro 
145                 150                 155                 160 


Gln Ile Thr Tyr Ser Ala Ile Ser Asp Glu Leu Arg Asp Lys Val Arg 
                165                 170                 175     


Phe Pro Ala Leu Leu Arg Thr Thr Pro Ser Ala Asp His His Ile Glu 
            180                 185                 190         


Ala Met Val Gln Leu Met Leu His Phe Arg Trp Asn Trp Ile Ile Val 
        195                 200                 205             


Leu Val Ser Ser Asp Thr Tyr Gly Arg Asp Asn Gly Gln Leu Leu Gly 
    210                 215                 220                 


Glu Arg Val Ala Arg Arg Asp Ile Cys Ile Ala Phe Gln Glu Thr Leu 
225                 230                 235                 240 


Pro Thr Leu Gln Pro Asn Gln Asn Met Thr Ser Glu Glu Arg Gln Arg 
                245                 250                 255     


Leu Val Thr Ile Val Asp Lys Leu Gln Gln Ser Thr Ala Arg Val Val 
            260                 265                 270         


Val Val Phe Ser Pro Asp Leu Thr Leu Tyr His Phe Phe Asn Glu Val 
        275                 280                 285             


Leu Arg Gln Asn Phe Thr Gly Ala Val Trp Ile Ala Ser Glu Ser Trp 
    290                 295                 300                 


Ala Ile Asp Pro Val Leu His Asn Leu Thr Glu Leu Arg His Leu Gly 
305                 310                 315                 320 


Thr Phe Leu Gly Ile Thr Ile Gln Ser Val Pro Ile Pro Gly Phe Ser 
                325                 330                 335     


Glu Phe Arg Glu Trp Gly Pro Gln Ala Gly Pro Pro Pro Leu Ser Arg 
            340                 345                 350         


Thr Ser Gln Ser Tyr Thr Cys Asn Gln Glu Cys Asp Asn Cys Leu Asn 
        355                 360                 365             


Ala Thr Leu Ser Phe Asn Thr Ile Leu Arg Leu Ser Gly Glu Arg Val 
    370                 375                 380                 


Val Tyr Ser Val Tyr Ser Ala Val Tyr Ala Val Ala His Ala Leu His 
385                 390                 395                 400 


Ser Leu Leu Gly Cys Asp Lys Ser Thr Cys Thr Lys Arg Val Val Tyr 
                405                 410                 415     


Pro Trp Gln Leu Leu Glu Glu Ile Trp Lys Val Asn Phe Thr Leu Leu 
            420                 425                 430         


Asp His Gln Ile Phe Phe Asp Pro Gln Gly Asp Val Ala Leu His Leu 
        435                 440                 445             


Glu Ile Val Gln Trp Gln Trp Asp Arg Ser Gln Asn Pro Phe Gln Ser 
    450                 455                 460                 


Val Ala Ser Tyr Tyr Pro Leu Gln Arg Gln Leu Lys Asn Ile Gln Asp 
465                 470                 475                 480 


Ile Ser Trp His Thr Ile Asn Asn Thr Ile Pro Met Ser Met Cys Ser 
                485                 490                 495     


Lys Arg Cys Gln Ser Gly Gln Lys Lys Lys Pro Val Gly Ile His Val 
            500                 505                 510         


Cys Cys Phe Glu Cys Ile Asp Cys Leu Pro Gly Thr Phe Leu Asn His 
        515                 520                 525             


Thr Glu Asp Glu Tyr Glu Cys Gln Ala Cys Pro Asn Asn Glu Trp Ser 
    530                 535                 540                 


Tyr Gln Ser Glu Thr Ser Cys Phe Lys Arg Gln Leu Val Phe Leu Glu 
545                 550                 555                 560 


Trp His Glu Ala Pro Thr Ile Ala Val Ala Leu Leu Ala Ala Leu Gly 
                565                 570                 575     


Phe Leu Ser Thr Leu Ala Ile Leu Val Ile Phe Trp Arg His Phe Gln 
            580                 585                 590         


Thr Pro Ile Val Arg Ser Ala Gly Gly Pro Met Cys Phe Leu Met Leu 
        595                 600                 605             


Thr Leu Leu Leu Val Ala Tyr Met Val Val Pro Val Tyr Val Gly Pro 
    610                 615                 620                 


Pro Lys Val Ser Thr Cys Leu Cys Arg Gln Ala Leu Phe Pro Leu Cys 
625                 630                 635                 640 


Phe Thr Ile Cys Ile Ser Cys Ile Ala Val Arg Ser Phe Gln Ile Val 
                645                 650                 655     


Cys Ala Phe Lys Met Ala Ser Arg Phe Pro Arg Ala Tyr Ser Tyr Trp 
            660                 665                 670         


Val Arg Tyr Gln Gly Pro Tyr Val Ser Met Ala Phe Ile Thr Val Leu 
        675                 680                 685             


Lys Met Val Ile Val Val Ile Gly Met Leu Ala Thr Gly Leu Ser Pro 
    690                 695                 700                 


Thr Thr Arg Thr Asp Pro Asp Asp Pro Lys Ile Thr Ile Val Ser Cys 
705                 710                 715                 720 


Asn Pro Asn Tyr Arg Asn Ser Leu Leu Phe Asn Thr Ser Leu Asp Leu 
                725                 730                 735     


Leu Leu Ser Val Val Gly Phe Ser Phe Ala Tyr Met Gly Lys Glu Leu 
            740                 745                 750         


Pro Thr Asn Tyr Asn Glu Ala Lys Phe Ile Thr Leu Ser Met Thr Phe 
        755                 760                 765             


Tyr Phe Thr Ser Ser Val Ser Leu Cys Thr Phe Met Ser Ala Tyr Ser 
    770                 775                 780                 


Gly Val Leu Val Thr Ile Val Asp Leu Leu Val Thr Val Leu Asn Leu 
785                 790                 795                 800 


Leu Ala Ile Ser Leu Gly Tyr Phe Gly Pro Lys Cys Tyr Met Ile Leu 
                805                 810                 815     


Phe Tyr Pro Glu Arg Asn Thr Pro Ala Tyr Phe Asn Ser Met Ile Gln 
            820                 825                 830         


Gly Tyr Thr Met Arg Arg Asp 
        835                 


<210>  6021
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  6021

Met Asn Gln Thr Asp Lys Asn Gln Gln Glu Ile Pro Ser Tyr Leu Asn 
1               5                   10                  15      


Asp Glu Pro Pro Glu Gly Ser Met Lys Asp His Pro Gln Gln Gln Pro 
            20                  25                  30          


Gly Met Leu Ser Arg Val Thr Gly Gly Ile Phe Ser Val Thr Lys Gly 
        35                  40                  45              


Ala Val Gly Ala Thr Ile Gly Gly Val Ala Trp Ile Gly Gly Lys Ser 
    50                  55                  60                  


Leu Glu Val Thr Lys Thr Ala Val Thr Thr Val Pro Ser Met Gly Ile 
65                  70                  75                  80  


Gly Leu Val Lys Gly Gly Val Ser Ala Val Ala Gly Gly Val Thr Ala 
                85                  90                  95      


Val Gly Ser Ala Val Val Asn Lys Val Pro Leu Thr Gly Lys Lys Lys 
            100                 105                 110         


Asp Lys Ser Asp 
        115     


<210>  6022
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  6022

Met Pro Gly Cys Pro Cys Pro Gly Cys Gly Met Ala Gly Pro Arg Leu 
1               5                   10                  15      


Leu Phe Leu Thr Ala Leu Ala Leu Glu Leu Leu Gly Arg Ala Gly Gly 
            20                  25                  30          


Ser Gln Pro Ala Leu Arg Ser Arg Gly Thr Ala Thr Ala Cys Arg Leu 
        35                  40                  45              


Asp Asn Lys Glu Ser Glu Ser Trp Gly Ala Leu Leu Ser Gly Glu Arg 
    50                  55                  60                  


Leu Asp Thr Trp Ile Cys Ser Leu Leu Gly Ser Leu Met Val Gly Leu 
65                  70                  75                  80  


Ser Gly Val Phe Pro Leu Leu Val Ile Pro Leu Glu Met Gly Thr Met 
                85                  90                  95      


Leu Arg Ser Glu Ala Gly Ala Trp Arg Leu Lys Gln Leu Leu Ser Phe 
            100                 105                 110         


Ala Leu Gly Gly Leu Leu Gly Asn Val Phe Leu His Leu Leu Pro Glu 
        115                 120                 125             


Ala Trp Ala Tyr Thr Cys Ser Ala Ser Pro Gly Gly Glu Gly Gln Ser 
    130                 135                 140                 


Leu Gln Gln Gln Gln Gln Leu Gly Leu Trp Val Ile Ala Gly Ile Leu 
145                 150                 155                 160 


Thr Phe Leu Ala Leu Glu Lys Met Phe Leu Asp Ser Lys Glu Glu Gly 
                165                 170                 175     


Thr Ser Gln Ala Pro Asn Lys Asp Pro Thr Ala Ala Ala Ala Ala Leu 
            180                 185                 190         


Asn Gly Gly His Cys Leu Ala Gln Pro Ala Ala Glu Pro Gly Leu Gly 
        195                 200                 205             


Ala Val Val Arg Ser Ile Lys Val Ser Gly Tyr Leu Asn Leu Leu Ala 
    210                 215                 220                 


Asn Thr Ile Asp Asn Phe Thr His Gly Leu Ala Val Ala Ala Ser Phe 
225                 230                 235                 240 


Leu Val Ser Lys Lys Ile Gly Leu Leu Thr Thr Met Ala Ile Leu Leu 
                245                 250                 255     


His Glu Ile Pro His Glu Val Gly Asp Phe Ala Ile Leu Leu Arg Ala 
            260                 265                 270         


Gly Phe Asp Arg Trp Ser Ala Ala Lys Leu Gln Leu Ser Thr Ala Leu 
        275                 280                 285             


Gly Gly Leu Leu Gly Ala Gly Phe Ala Ile Cys Thr Gln Ser Pro Lys 
    290                 295                 300                 


Gly Val Glu Glu Thr Ala Ala Trp Val Leu Pro Phe Thr Ser Gly Gly 
305                 310                 315                 320 


Phe Leu Tyr Ile Ala Leu Val Asn Val Leu Pro Asp Leu Leu Glu Glu 
                325                 330                 335     


Glu Asp Pro Trp Arg Ser Leu Gln Gln Leu Leu Leu Leu Cys Ala Gly 
            340                 345                 350         


Ile Val Val Met Val Leu Phe Ser Leu Phe Val Asp 
        355                 360                 


<210>  6023
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  6023

Met Ala Glu Ile Thr Asn Ile Arg Pro Ser Phe Asp Val Ser Pro Val 
1               5                   10                  15      


Val Ala Gly Leu Ile Gly Ala Ser Val Leu Val Val Cys Val Ser Val 
            20                  25                  30          


Thr Val Phe Val Trp Ser Cys Cys His Gln Gln Ala Glu Lys Lys Gln 
        35                  40                  45              


Lys Asn Pro Pro Tyr Lys Phe Ile His Met Leu Lys Gly Ile Ser Ile 
    50                  55                  60                  


Tyr Pro Glu Thr Leu Ser Asn Lys Lys Lys Ile Ile Lys Val Arg Arg 
65                  70                  75                  80  


Asp Lys Asp Gly Pro Gly Arg Glu Gly Gly Arg Arg Asn Leu Leu Val 
                85                  90                  95      


Asp Ala Ala Glu Ala Gly Leu Leu Ser Arg Asp Lys Asp Pro Arg Gly 
            100                 105                 110         


Pro Ser Ser Gly Ser Cys Ile Asp Gln Leu Pro Ile Lys Met Asp Tyr 
        115                 120                 125             


Gly Glu Glu Leu Arg Ser Pro Ile Thr Ser Leu Thr Pro Gly Glu Ser 
    130                 135                 140                 


Lys Thr Thr Ser Pro Ser Ser Pro Glu Glu Asp Val Met Leu Gly Ser 
145                 150                 155                 160 


Leu Thr Phe Ser Val Asp Tyr Asn Phe Pro Lys Lys Ala Leu Val Val 
                165                 170                 175     


Thr Ile Gln Glu Ala His Gly Leu Pro Val Met Asp Asp Gln Thr Gln 
            180                 185                 190         


Gly Ser Asp Pro Tyr Ile Lys Met Thr Ile Leu Pro Asp Lys Arg His 
        195                 200                 205             


Arg Val Lys Thr Arg Val Leu Arg Lys Thr Leu Asp Pro Val Phe Asp 
    210                 215                 220                 


Glu Thr Phe Thr Phe Tyr Gly Ile Pro Tyr Ser Gln Leu Gln Asp Leu 
225                 230                 235                 240 


Val Leu His Phe Leu Val Leu Ser Phe Asp Arg Phe Ser Arg Asp Asp 
                245                 250                 255     


Val Ile Gly Glu Val Met Val Pro Leu Ala Gly Val Asp Pro Ser Thr 
            260                 265                 270         


Gly Lys Val Gln Leu Thr Arg Asp Ile Ile Lys Arg Asn Ile Gln Lys 
        275                 280                 285             


Cys Ile Ser Arg Gly Glu Leu Gln Val Ser Leu Ser Tyr Gln Pro Val 
    290                 295                 300                 


Ala Gln Arg Met Thr Val Val Val Leu Lys Ala Arg His Leu Pro Lys 
305                 310                 315                 320 


Met Asp Ile Thr Gly Leu Ser Gly Asn Pro Tyr Val Lys Val Asn Val 
                325                 330                 335     


Tyr Tyr Gly Arg Lys Arg Ile Ala Lys Lys Lys Thr His Val Lys Lys 
            340                 345                 350         


Cys Thr Leu Asn Pro Ile Phe Asn Glu Ser Phe Ile Tyr Asp Ile Pro 
        355                 360                 365             


Thr Asp Leu Leu Pro Asp Ile Ser Ile Glu Phe Leu Val Ile Asp Phe 
    370                 375                 380                 


Asp Arg Thr Thr Lys Asn Glu Val Val Gly Arg Leu Ile Leu Gly Ala 
385                 390                 395                 400 


His Ser Val Thr Ala Ser Gly Ala Glu His Trp Arg Glu Val Cys Glu 
                405                 410                 415     


Ser Pro Arg Lys Pro Val Ala Lys Trp His Ser Leu Ser Glu Tyr 
            420                 425                 430     


<210>  6024
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  6024

Met Leu Phe Arg Asn Arg Phe Leu Leu Leu Leu Ala Leu Ala Ala Leu 
1               5                   10                  15      


Leu Ala Phe Val Ser Leu Ser Leu Gln Phe Phe His Leu Ile Pro Val 
            20                  25                  30          


Ser Thr Pro Lys Asn Gly Met Ser Ser Lys Ser Arg Lys Arg Ile Met 
        35                  40                  45              


Pro Asp Pro Val Thr Glu Pro Pro Val Thr Asp Pro Val Tyr Glu Ala 
    50                  55                  60                  


Leu Leu Tyr Cys Asn Ile Pro Ser Val Ala Glu Arg Ser Met Glu Gly 
65                  70                  75                  80  


His Ala Pro His His Phe Lys Leu Val Ser Val His Val Phe Ile Arg 
                85                  90                  95      


His Gly Asp Arg Tyr Pro Leu Tyr Val Ile Pro Lys Thr Lys Arg Pro 
            100                 105                 110         


Glu Ile Asp Cys Thr Leu Val Ala Asn Arg Lys Pro Tyr His Pro Lys 
        115                 120                 125             


Leu Glu Ala Phe Ile Ser His Met Ser Lys Gly Ser Gly Ala Ser Phe 
    130                 135                 140                 


Glu Ser Pro Leu Asn Ser Leu Pro Leu Tyr Pro Asn His Pro Leu Cys 
145                 150                 155                 160 


Glu Met Gly Glu Leu Thr Gln Thr Gly Val Val Gln His Leu Gln Asn 
                165                 170                 175     


Gly Gln Leu Leu Arg Asp Ile Tyr Leu Lys Lys His Lys Leu Leu Pro 
            180                 185                 190         


Asn Asp Trp Ser Ala Asp Gln Leu Tyr Leu Glu Thr Thr Gly Lys Ser 
        195                 200                 205             


Arg Thr Leu Gln Ser Gly Leu Ala Leu Leu Tyr Gly Phe Leu Pro Asp 
    210                 215                 220                 


Phe Asp Trp Lys Lys Ile Tyr Phe Arg His Gln Pro Ser Ala Leu Phe 
225                 230                 235                 240 


Cys Ser Gly Ser Cys Tyr Cys Pro Val Arg Asn Gln Tyr Leu Glu Lys 
                245                 250                 255     


Glu Gln Arg Arg Gln Tyr Leu Leu Arg Leu Lys Asn Ser Gln Leu Glu 
            260                 265                 270         


Lys Thr Tyr Gly Glu Met Ala Lys Ile Val Asp Val Pro Thr Lys Gln 
        275                 280                 285             


Leu Arg Ala Ala Asn Pro Ile Asp Ser Met Leu Cys His Phe Cys His 
    290                 295                 300                 


Asn Val Ser Phe Pro Cys Thr Arg Asn Gly Cys Val Asp Met Glu His 
305                 310                 315                 320 


Phe Lys Val Ile Lys Thr His Gln Ile Glu Asp Glu Arg Glu Arg Arg 
                325                 330                 335     


Glu Lys Lys Leu Tyr Phe Gly Tyr Ser Leu Leu Gly Ala His Pro Ile 
            340                 345                 350         


Leu Asn Gln Thr Ile Gly Arg Met Gln Arg Ala Thr Glu Gly Arg Lys 
        355                 360                 365             


Glu Glu Leu Phe Ala Leu Tyr Ser Ala His Asp Val Thr Leu Ser Pro 
    370                 375                 380                 


Val Leu Ser Ala Leu Gly Leu Ser Glu Ala Arg Phe Pro Arg Phe Ala 
385                 390                 395                 400 


Ala Arg Leu Ile Phe Glu Leu Trp Gln Asp Arg Glu Lys Pro Ser Glu 
                405                 410                 415     


His Ser Val Arg Ile Leu Tyr Asn Gly Val Asp Val Thr Phe His Thr 
            420                 425                 430         


Ser Phe Cys Gln Asp His His Lys Arg Ser Pro Lys Pro Met Cys Pro 
        435                 440                 445             


Leu Glu Asn Leu Val Arg Phe Val Lys Arg Asp Met Phe Val Ala Leu 
    450                 455                 460                 


Gly Gly Ser Gly Thr Asn Tyr Tyr Asp Ala Cys His Arg Glu Gly Phe 
465                 470                 475                 480 


<210>  6025
<211>  1317
<212>  PRT
<213>  Homo sapiens

<400>  6025

Met Glu Glu Glu Lys Asp Asp Ser Pro Gln Leu Thr Gly Ile Ala Val 
1               5                   10                  15      


Gly Ala Leu Leu Ala Leu Ala Leu Val Gly Val Leu Ile Leu Phe Met 
            20                  25                  30          


Phe Arg Arg Leu Arg Gln Phe Arg Gln Ala Gln Pro Thr Pro Gln Tyr 
        35                  40                  45              


Arg Phe Arg Lys Arg Asp Lys Val Met Phe Tyr Gly Arg Lys Ile Met 
    50                  55                  60                  


Arg Lys Val Thr Thr Leu Pro Asn Thr Leu Val Glu Asn Thr Ala Leu 
65                  70                  75                  80  


Pro Arg Gln Arg Ala Arg Lys Arg Thr Lys Val Leu Ser Leu Ala Lys 
                85                  90                  95      


Arg Ile Leu Arg Phe Lys Lys Glu Tyr Pro Ala Leu Gln Pro Lys Glu 
            100                 105                 110         


Pro Pro Pro Ser Leu Leu Glu Ala Asp Leu Thr Glu Phe Asp Val Lys 
        115                 120                 125             


Asn Ser His Leu Pro Ser Glu Val Leu Tyr Met Leu Lys Asn Val Arg 
    130                 135                 140                 


Val Leu Gly His Phe Glu Lys Pro Leu Phe Leu Glu Leu Cys Lys His 
145                 150                 155                 160 


Ile Val Phe Val Gln Leu Gln Glu Gly Glu His Val Phe Gln Pro Arg 
                165                 170                 175     


Glu Pro Asp Pro Ser Ile Cys Val Val Gln Asp Gly Arg Leu Glu Val 
            180                 185                 190         


Cys Ile Gln Asp Thr Asp Gly Thr Glu Val Val Val Lys Glu Val Leu 
        195                 200                 205             


Ala Gly Asp Ser Val His Ser Leu Leu Ser Ile Leu Asp Ile Ile Thr 
    210                 215                 220                 


Gly His Ala Ala Pro Tyr Lys Thr Val Ser Val Arg Ala Ala Ile Pro 
225                 230                 235                 240 


Ser Thr Ile Leu Arg Leu Pro Ala Ala Ala Phe His Gly Val Phe Glu 
                245                 250                 255     


Lys Tyr Pro Glu Thr Leu Val Arg Val Val Gln Ile Ile Met Val Arg 
            260                 265                 270         


Leu Gln Arg Val Thr Phe Leu Ala Leu His Asn Tyr Leu Gly Leu Thr 
        275                 280                 285             


Thr Glu Leu Phe Asn Ala Glu Ser Gln Ala Ile Pro Leu Val Ser Val 
    290                 295                 300                 


Ala Ser Val Ala Ala Gly Lys Ala Lys Lys Gln Val Phe Tyr Gly Glu 
305                 310                 315                 320 


Glu Glu Arg Leu Lys Lys Pro Pro Arg Leu Gln Glu Ser Cys Asp Ser 
                325                 330                 335     


Asp His Gly Gly Gly Arg Pro Ala Ala Ala Gly Pro Leu Leu Lys Arg 
            340                 345                 350         


Ser His Ser Val Pro Ala Pro Ser Ile Arg Lys Gln Ile Leu Glu Glu 
        355                 360                 365             


Leu Glu Lys Pro Gly Ala Gly Asp Pro Asp Pro Ser Ala Pro Gln Gly 
    370                 375                 380                 


Gly Pro Gly Ser Ala Thr Ser Asp Leu Gly Met Ala Cys Asp Arg Ala 
385                 390                 395                 400 


Arg Val Phe Leu His Ser Asp Glu His Pro Gly Ser Ser Val Ala Ser 
                405                 410                 415     


Lys Ser Arg Lys Ser Val Met Val Ala Glu Ile Pro Ser Thr Val Ser 
            420                 425                 430         


Gln His Ser Glu Ser His Thr Asp Glu Thr Leu Ala Ser Arg Lys Ser 
        435                 440                 445             


Asp Ala Ile Phe Arg Ala Ala Lys Lys Asp Leu Leu Thr Leu Met Lys 
    450                 455                 460                 


Leu Glu Asp Ser Ser Leu Leu Asp Gly Arg Val Ala Leu Leu His Val 
465                 470                 475                 480 


Pro Ala Gly Thr Val Val Ser Arg Gln Gly Asp Gln Asp Ala Ser Ile 
                485                 490                 495     


Leu Phe Val Val Ser Gly Leu Leu His Val Tyr Gln Arg Lys Ile Gly 
            500                 505                 510         


Ser Gln Glu Asp Thr Cys Leu Phe Leu Thr Arg Pro Gly Glu Met Val 
        515                 520                 525             


Gly Gln Leu Ala Val Leu Thr Gly Glu Pro Leu Ile Phe Thr Val Lys 
    530                 535                 540                 


Ala Asn Arg Asp Cys Ser Phe Leu Ser Ile Ser Lys Ala His Phe Tyr 
545                 550                 555                 560 


Glu Ile Met Arg Lys Gln Pro Thr Val Val Leu Gly Val Ala His Thr 
                565                 570                 575     


Val Val Lys Arg Met Ser Ser Phe Val Arg Gln Ile Asp Phe Ala Leu 
            580                 585                 590         


Asp Trp Val Glu Val Glu Ala Gly Arg Ala Ile Tyr Arg Gln Gly Asp 
        595                 600                 605             


Lys Ser Asp Cys Thr Tyr Ile Met Leu Ser Gly Arg Leu Arg Ser Val 
    610                 615                 620                 


Ile Arg Lys Asp Asp Gly Lys Lys Arg Leu Ala Gly Glu Tyr Gly Arg 
625                 630                 635                 640 


Gly Asp Leu Val Gly Val Val Glu Thr Leu Thr His Gln Ala Arg Ala 
                645                 650                 655     


Thr Thr Val His Ala Val Arg Asp Ser Glu Leu Ala Lys Leu Pro Ala 
            660                 665                 670         


Gly Ala Leu Thr Ser Ile Lys Arg Arg Tyr Pro Gln Val Val Thr Arg 
        675                 680                 685             


Leu Ile His Leu Leu Gly Glu Lys Ile Leu Gly Ser Leu Gln Gln Gly 
    690                 695                 700                 


Pro Val Thr Gly His Gln Leu Gly Leu Pro Thr Glu Gly Ser Lys Trp 
705                 710                 715                 720 


Asp Leu Gly Asn Pro Ala Val Asn Leu Ser Thr Val Ala Val Met Pro 
                725                 730                 735     


Val Ser Glu Glu Val Pro Leu Thr Ala Phe Ala Leu Glu Leu Glu His 
            740                 745                 750         


Ala Leu Ser Ala Ile Gly Pro Thr Leu Leu Leu Thr Ser Asp Asn Ile 
        755                 760                 765             


Lys Arg Arg Leu Gly Ser Ala Ala Leu Asp Ser Val His Glu Tyr Arg 
    770                 775                 780                 


Leu Ser Ser Trp Leu Gly Gln Gln Glu Asp Thr His Arg Ile Val Leu 
785                 790                 795                 800 


Tyr Gln Ala Asp Gly Thr Leu Thr Pro Trp Thr Gln Arg Cys Val Arg 
                805                 810                 815     


Gln Ala Asp Cys Ile Leu Ile Val Gly Leu Gly Asp Gln Glu Pro Thr 
            820                 825                 830         


Val Gly Glu Leu Glu Arg Met Leu Glu Ser Thr Ala Val Arg Ala Gln 
        835                 840                 845             


Lys Gln Leu Ile Leu Leu His Arg Glu Glu Gly Pro Ala Pro Ala Arg 
    850                 855                 860                 


Thr Val Glu Trp Leu Asn Met Arg Ser Trp Cys Ser Gly His Leu His 
865                 870                 875                 880 


Leu Cys Cys Pro Arg Arg Val Phe Ser Arg Arg Ser Leu Pro Lys Leu 
                885                 890                 895     


Val Glu Met Tyr Lys His Val Phe Gln Arg Pro Pro Asp Arg His Ser 
            900                 905                 910         


Asp Phe Ser Arg Leu Ala Arg Val Leu Thr Gly Asn Ala Ile Ala Leu 
        915                 920                 925             


Val Leu Gly Gly Gly Gly Ala Arg Gly Cys Ala Gln Val Gly Val Leu 
    930                 935                 940                 


Lys Ala Leu Ala Glu Cys Gly Ile Pro Val Asp Met Val Gly Gly Thr 
945                 950                 955                 960 


Ser Ile Gly Ala Phe Val Gly Ala Leu Tyr Ser Glu Glu Arg Asn Tyr 
                965                 970                 975     


Ser Gln Met Arg Ile Arg Ala Lys Gln Trp Ala Glu Gly Met Thr Ser 
            980                 985                 990         


Leu Met Lys Ala Ala Leu Asp Leu  Thr Tyr Pro Ile Thr  Ser Met Phe 
        995                 1000                 1005             


Ser Gly  Ala Gly Phe Asn Ser  Ser Ile Phe Ser Val  Phe Lys Asp 
    1010                 1015                 1020             


Gln Gln  Ile Glu Asp Leu Trp  Ile Pro Tyr Phe Ala  Ile Thr Thr 
    1025                 1030                 1035             


Asp Ile  Thr Ala Ser Ala Met  Arg Val His Thr Asp  Gly Ser Leu 
    1040                 1045                 1050             


Trp Trp  Tyr Val Arg Ala Ser  Met Ser Leu Ser Gly  Tyr Met Pro 
    1055                 1060                 1065             


Pro Leu  Cys Asp Pro Lys Asp  Gly His Leu Leu Met  Asp Gly Gly 
    1070                 1075                 1080             


Tyr Ile  Asn Asn Leu Pro Ala  Asp Val Ala Arg Ser  Met Gly Ala 
    1085                 1090                 1095             


Lys Val  Val Ile Ala Ile Asp  Val Gly Ser Arg Asp  Glu Thr Asp 
    1100                 1105                 1110             


Leu Thr  Asn Tyr Gly Asp Ala  Leu Ser Gly Trp Trp  Leu Leu Trp 
    1115                 1120                 1125             


Lys Arg  Trp Asn Pro Leu Ala  Thr Lys Val Lys Val  Leu Asn Met 
    1130                 1135                 1140             


Ala Glu  Ile Gln Thr Arg Leu  Ala Tyr Val Cys Cys  Val Arg Gln 
    1145                 1150                 1155             


Leu Glu  Val Val Lys Ser Ser  Asp Tyr Cys Glu Tyr  Leu Arg Pro 
    1160                 1165                 1170             


Pro Ile  Asp Ser Tyr Ser Thr  Leu Asp Phe Gly Lys  Phe Asn Glu 
    1175                 1180                 1185             


Ile Cys  Glu Val Gly Tyr Gln  His Gly Arg Thr Val  Phe Asp Ile 
    1190                 1195                 1200             


Trp Gly  Arg Ser Gly Val Leu  Glu Lys Met Leu Arg  Asp Gln Gln 
    1205                 1210                 1215             


Gly Pro  Ser Lys Lys Pro Ala  Ser Ala Val Leu Thr  Cys Pro Asn 
    1220                 1225                 1230             


Ala Ser  Phe Thr Asp Leu Ala  Glu Ile Val Ser Arg  Ile Glu Pro 
    1235                 1240                 1245             


Ala Lys  Pro Ala Met Val Asp  Asp Glu Ser Asp Tyr  Gln Thr Glu 
    1250                 1255                 1260             


Tyr Glu  Glu Glu Leu Leu Asp  Val Pro Arg Asp Ala  Tyr Ala Asp 
    1265                 1270                 1275             


Phe Gln  Ser Thr Ser Ala Gln  Gln Gly Ser Asp Leu  Glu Asp Glu 
    1280                 1285                 1290             


Ser Ser  Leu Arg His Arg His  Pro Ser Leu Ala Phe  Pro Lys Leu 
    1295                 1300                 1305             


Ser Glu  Gly Ser Ser Asp Gln  Asp Gly 
    1310                 1315         


<210>  6026
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  6026

Met Lys Gly Gly Glu Gly Asp Ala Gly Glu Gln Ala Pro Leu Asn Pro 
1               5                   10                  15      


Glu Gly Glu Ser Pro Ala Gly Ser Ala Thr Tyr Arg Glu Phe Val His 
            20                  25                  30          


Arg Gly Tyr Leu Asp Leu Met Gly Ala Ser Gln His Ser Leu Arg Ala 
        35                  40                  45              


Leu Ser Trp Arg Arg Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser 
    50                  55                  60                  


Ser Arg Thr Ser Ala Leu Leu Ser Gly Phe Ala Met Val Ala Met Val 
65                  70                  75                  80  


Glu Val Gln Leu Glu Ser Asp His Glu Tyr Pro Pro Gly Leu Leu Val 
                85                  90                  95      


Ala Phe Ser Ala Cys Thr Thr Val Leu Val Ala Val His Leu Phe Ala 
            100                 105                 110         


Leu Met Val Ser Thr Cys Leu Leu Pro His Ile Glu Ala Val Ser Asn 
        115                 120                 125             


Ile His Asn Leu Asn Ser Val His Gln Ser Pro His Gln Arg Leu His 
    130                 135                 140                 


Arg Tyr Val Glu Leu Ala Trp Gly Phe Ser Thr Ala Leu Gly Thr Phe 
145                 150                 155                 160 


Leu Phe Leu Ala Glu Val Val Leu Val Gly Trp Val Lys Phe Val Pro 
                165                 170                 175     


Ile Gly Ala Pro Leu Asp Thr Pro Thr Pro Met Val Pro Thr Ser Arg 
            180                 185                 190         


Val Pro Gly Thr Leu Ala Pro Val Ala Thr Ser Leu Ser Pro Ala Ser 
        195                 200                 205             


Asn Leu Pro Arg Ser Ser Ala Ser Ala Ala Pro Ser Gln Ala Glu Pro 
    210                 215                 220                 


Ala Cys Pro Pro Arg Gln Ala Cys Gly Gly Gly Gly Ala His Gly Pro 
225                 230                 235                 240 


Gly Trp Gln Ala Ala Met Ala Ser Thr Ala Ile Met Val Pro Val Gly 
                245                 250                 255     


Leu Val Phe Val Ala Phe Ala Leu His Phe Tyr Arg Ser Leu Val Ala 
            260                 265                 270         


His Lys Thr Asp Arg Tyr Lys Gln Glu Leu Glu Glu Leu Asn Arg Leu 
        275                 280                 285             


Gln Gly Glu Leu Gln Ala Val 
    290                 295 


<210>  6027
<211>  1013
<212>  PRT
<213>  Homo sapiens

<400>  6027

Met Gly Asp Lys Lys Asp Asp Lys Asp Ser Pro Lys Lys Asn Lys Gly 
1               5                   10                  15      


Lys Glu Arg Arg Asp Leu Asp Asp Leu Lys Lys Glu Val Ala Met Thr 
            20                  25                  30          


Glu His Lys Met Ser Val Glu Glu Val Cys Arg Lys Tyr Asn Thr Asp 
        35                  40                  45              


Cys Val Gln Gly Leu Thr His Ser Lys Ala Gln Glu Ile Leu Ala Arg 
    50                  55                  60                  


Asp Gly Pro Asn Ala Leu Thr Pro Pro Pro Thr Thr Pro Glu Trp Val 
65                  70                  75                  80  


Lys Phe Cys Arg Gln Leu Phe Gly Gly Phe Ser Ile Leu Leu Trp Ile 
                85                  90                  95      


Gly Ala Ile Leu Cys Phe Leu Ala Tyr Gly Ile Gln Ala Gly Thr Glu 
            100                 105                 110         


Asp Asp Pro Ser Gly Asp Asn Leu Tyr Leu Gly Ile Val Leu Ala Ala 
        115                 120                 125             


Val Val Ile Ile Thr Gly Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser 
    130                 135                 140                 


Ser Lys Ile Met Glu Ser Phe Lys Asn Met Val Pro Gln Gln Ala Leu 
145                 150                 155                 160 


Val Ile Arg Glu Gly Glu Lys Met Gln Val Asn Ala Glu Glu Val Val 
                165                 170                 175     


Val Gly Asp Leu Val Glu Ile Lys Gly Gly Asp Arg Val Pro Ala Asp 
            180                 185                 190         


Leu Arg Ile Ile Ser Ala His Gly Cys Lys Val Asp Asn Ser Ser Leu 
        195                 200                 205             


Thr Gly Glu Ser Glu Pro Gln Thr Arg Ser Pro Asp Cys Thr His Asp 
    210                 215                 220                 


Asn Pro Leu Glu Thr Arg Asn Ile Thr Phe Phe Ser Thr Asn Cys Val 
225                 230                 235                 240 


Glu Gly Thr Ala Arg Gly Val Val Val Ala Thr Gly Asp Arg Thr Val 
                245                 250                 255     


Met Gly Arg Ile Ala Thr Leu Ala Ser Gly Leu Glu Val Gly Lys Thr 
            260                 265                 270         


Pro Ile Ala Ile Glu Ile Glu His Phe Ile Gln Leu Ile Thr Gly Val 
        275                 280                 285             


Ala Val Phe Leu Gly Val Ser Phe Phe Ile Leu Ser Leu Ile Leu Gly 
    290                 295                 300                 


Tyr Thr Trp Leu Glu Ala Val Ile Phe Leu Ile Gly Ile Ile Val Ala 
305                 310                 315                 320 


Asn Val Pro Glu Gly Leu Leu Ala Thr Val Thr Val Cys Leu Thr Leu 
                325                 330                 335     


Thr Ala Lys Arg Met Ala Arg Lys Asn Cys Leu Val Lys Asn Leu Glu 
            340                 345                 350         


Ala Val Glu Thr Leu Gly Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr 
        355                 360                 365             


Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ala His Met Trp Phe Asp 
    370                 375                 380                 


Asn Gln Ile His Glu Ala Asp Thr Thr Glu Asp Gln Ser Gly Thr Ser 
385                 390                 395                 400 


Phe Asp Lys Ser Ser His Thr Trp Val Ala Leu Ser His Ile Ala Gly 
                405                 410                 415     


Leu Cys Asn Arg Ala Val Phe Lys Gly Gly Gln Asp Asn Ile Pro Val 
            420                 425                 430         


Leu Lys Arg Asp Val Ala Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys 
        435                 440                 445             


Cys Ile Glu Leu Ser Ser Gly Ser Val Lys Leu Met Arg Glu Arg Asn 
    450                 455                 460                 


Lys Lys Val Ala Glu Ile Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu 
465                 470                 475                 480 


Ser Ile His Glu Thr Glu Asp Pro Asn Asp Asn Arg Tyr Leu Leu Val 
                485                 490                 495     


Met Lys Gly Ala Pro Glu Arg Ile Leu Asp Arg Cys Ser Thr Ile Leu 
            500                 505                 510         


Leu Gln Gly Lys Glu Gln Pro Leu Asp Glu Glu Met Lys Glu Ala Phe 
        515                 520                 525             


Gln Asn Ala Tyr Leu Glu Leu Gly Gly Leu Gly Glu Arg Val Leu Gly 
    530                 535                 540                 


Phe Cys His Tyr Tyr Leu Pro Glu Glu Gln Phe Pro Lys Gly Phe Ala 
545                 550                 555                 560 


Phe Asp Cys Asp Asp Val Asn Phe Thr Thr Asp Asn Leu Cys Phe Val 
                565                 570                 575     


Gly Leu Met Ser Met Ile Asp Pro Pro Arg Ala Ala Val Pro Asp Ala 
            580                 585                 590         


Val Gly Lys Cys Arg Ser Ala Gly Ile Lys Val Ile Met Val Thr Gly 
        595                 600                 605             


Asp His Pro Ile Thr Ala Lys Ala Ile Ala Lys Gly Val Gly Ile Ile 
    610                 615                 620                 


Ser Glu Gly Asn Glu Thr Val Glu Asp Ile Ala Ala Arg Leu Asn Ile 
625                 630                 635                 640 


Pro Val Ser Gln Val Asn Pro Arg Asp Ala Lys Ala Cys Val Ile His 
                645                 650                 655     


Gly Thr Asp Leu Lys Asp Phe Thr Ser Glu Gln Ile Asp Glu Ile Leu 
            660                 665                 670         


Gln Asn His Thr Glu Ile Val Phe Ala Arg Thr Ser Pro Gln Gln Lys 
        675                 680                 685             


Leu Ile Ile Val Glu Gly Cys Gln Arg Gln Gly Ala Ile Val Ala Val 
    690                 695                 700                 


Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile 
705                 710                 715                 720 


Gly Val Ala Met Gly Ile Ala Gly Ser Asp Val Ser Lys Gln Ala Ala 
                725                 730                 735     


Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser Ile Val Thr Gly Val 
            740                 745                 750         


Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr 
        755                 760                 765             


Thr Leu Thr Ser Asn Ile Pro Glu Ile Thr Pro Phe Leu Leu Phe Ile 
    770                 775                 780                 


Met Ala Asn Ile Pro Leu Pro Leu Gly Thr Ile Thr Ile Leu Cys Ile 
785                 790                 795                 800 


Asp Leu Gly Thr Asp Met Val Pro Ala Ile Ser Leu Ala Tyr Glu Ala 
                805                 810                 815     


Ala Glu Ser Asp Ile Met Lys Arg Gln Pro Arg Asn Pro Arg Thr Asp 
            820                 825                 830         


Lys Leu Val Asn Glu Arg Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly 
        835                 840                 845             


Met Ile Gln Ala Leu Gly Gly Phe Phe Ser Tyr Phe Val Ile Leu Ala 
    850                 855                 860                 


Glu Asn Gly Phe Leu Pro Gly Asn Leu Val Gly Ile Arg Leu Asn Trp 
865                 870                 875                 880 


Asp Asp Arg Thr Val Asn Asp Leu Glu Asp Ser Tyr Gly Gln Gln Trp 
                885                 890                 895     


Thr Tyr Glu Gln Arg Lys Val Val Glu Phe Thr Cys His Thr Ala Phe 
            900                 905                 910         


Phe Val Ser Ile Val Val Val Gln Trp Ala Asp Leu Ile Ile Cys Lys 
        915                 920                 925             


Thr Arg Arg Asn Ser Val Phe Gln Gln Gly Met Lys Asn Lys Ile Leu 
    930                 935                 940                 


Ile Phe Gly Leu Phe Glu Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr 
945                 950                 955                 960 


Cys Pro Gly Met Asp Val Ala Leu Arg Met Tyr Pro Leu Lys Pro Ser 
                965                 970                 975     


Trp Trp Phe Cys Ala Phe Pro Tyr Ser Phe Leu Ile Phe Val Tyr Asp 
            980                 985                 990         


Glu Ile Arg Lys Leu Ile Leu Arg  Arg Asn Pro Gly Gly  Trp Val Glu 
        995                 1000                 1005             


Lys Glu  Thr Tyr Tyr 
    1010             


<210>  6028
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  6028

Met Val Thr Ala Met Asn Val Ser His Glu Val Asn Gln Leu Phe Gln 
1               5                   10                  15      


Pro Tyr Asn Phe Glu Leu Ser Lys Asp Met Arg Pro Phe Phe Glu Glu 
            20                  25                  30          


Tyr Trp Ala Thr Ser Phe Pro Ile Ala Leu Ile Tyr Leu Val Leu Ile 
        35                  40                  45              


Ala Val Gly Gln Asn Tyr Met Lys Glu Arg Lys Gly Phe Asn Leu Gln 
    50                  55                  60                  


Gly Pro Leu Ile Leu Trp Ser Phe Cys Leu Ala Ile Phe Ser Ile Leu 
65                  70                  75                  80  


Gly Ala Val Arg Met Trp Gly Ile Met Gly Thr Val Leu Leu Thr Gly 
                85                  90                  95      


Gly Leu Lys Gln Thr Val Cys Phe Ile Asn Phe Ile Asp Asn Ser Thr 
            100                 105                 110         


Val Lys Phe Trp Ser Trp Val Phe Leu Leu Ser Lys Val Ile Glu Leu 
        115                 120                 125             


Gly Asp Thr Ala Phe Ile Ile Leu Arg Lys Arg Pro Leu Ile Phe Ile 
    130                 135                 140                 


His Trp Tyr His His Ser Thr Val Leu Val Tyr Thr Ser Phe Gly Tyr 
145                 150                 155                 160 


Lys Asn Lys Val Pro Ala Gly Gly Trp Phe Val Thr Met Asn Phe Gly 
                165                 170                 175     


Val His Ala Ile Met Tyr Thr Tyr Tyr Thr Leu Lys Ala Ala Asn Val 
            180                 185                 190         


Lys Pro Pro Lys Met Leu Pro Met Leu Ile Thr Ser Leu Gln Ile Leu 
        195                 200                 205             


Gln Met Phe Val Gly Ala Ile Val Ser Ile Leu Thr Tyr Ile Trp Arg 
    210                 215                 220                 


Gln Asp Gln Gly Cys His Thr Thr Met Glu His Leu Phe Trp Ser Phe 
225                 230                 235                 240 


Ile Leu Tyr Met Thr Tyr Phe Ile Leu Phe Ala His Phe Phe Cys Gln 
                245                 250                 255     


Thr Tyr Ile Arg Pro Lys Val Lys Ala Lys Thr Lys Ser Gln 
            260                 265                 270 


<210>  6029
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  6029

Met Pro Thr Thr Lys Lys Thr Leu Met Phe Leu Ser Ser Phe Phe Thr 
1               5                   10                  15      


Ser Leu Gly Ser Phe Ile Val Ile Cys Ser Ile Leu Gly Thr Gln Ala 
            20                  25                  30          


Trp Ile Thr Ser Thr Ile Ala Val Arg Asp Ser Ala Ser Asn Gly Ser 
        35                  40                  45              


Ile Phe Ile Thr Tyr Gly Leu Phe Arg Gly Glu Ser Ser Glu Glu Leu 
    50                  55                  60                  


Ser His Gly Leu Ala Glu Pro Lys Lys Lys Phe Ala Val Leu Glu Ile 
65                  70                  75                  80  


Leu Asn Asn Ser Ser Gln Lys Thr Leu His Ser Val Thr Ile Leu Phe 
                85                  90                  95      


Leu Val Leu Ser Leu Ile Thr Ser Leu Leu Ser Ser Gly Phe Thr Phe 
            100                 105                 110         


Tyr Asn Ser Ile Ser Asn Pro Tyr Gln Thr Phe Leu Gly Pro Thr Gly 
        115                 120                 125             


Val Tyr Thr Trp Asn Gly Leu Gly Ala Ser Phe Val Phe Val Thr Met 
    130                 135                 140                 


Ile Leu Phe Val Ala Asn Thr Gln Ser Asn Gln Leu Ser Glu Glu Leu 
145                 150                 155                 160 


Phe Gln Met Leu Tyr Pro Ala Thr Thr Ser Lys Gly Thr Thr His Ser 
                165                 170                 175     


Tyr Gly Tyr Ser Phe Trp Leu Ile Leu Leu Val Ile Leu Leu Asn Ile 
            180                 185                 190         


Val Thr Val Thr Ile Ile Ile Phe Tyr Gln Lys Ala Arg Tyr Gln Arg 
        195                 200                 205             


Lys Gln Glu Gln Arg Lys Pro Met Glu Tyr Ala Pro Arg Asp Gly Ile 
    210                 215                 220                 


Leu Phe 
225     


<210>  6030
<211>  721
<212>  PRT
<213>  Homo sapiens

<400>  6030

Met Leu Pro Arg Gly Arg Pro Arg Ala Leu Gly Ala Ala Ala Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gly Phe Leu Leu Phe Gly Gly Asp Leu Gly 
            20                  25                  30          


Cys Glu Arg Arg Glu Pro Gly Gly Arg Ala Gly Ala Pro Gly Cys Phe 
        35                  40                  45              


Pro Gly Pro Leu Met Pro Arg Val Pro Pro Asp Gly Arg Leu Arg Arg 
    50                  55                  60                  


Ala Ala Ala Leu Asp Gly Asp Pro Gly Ala Gly Pro Gly Asp His Asn 
65                  70                  75                  80  


Arg Ser Asp Cys Gly Pro Gln Pro Pro Pro Pro Pro Lys Cys Glu Leu 
                85                  90                  95      


Leu His Val Ala Ile Val Cys Ala Gly His Asn Ser Ser Arg Asp Val 
            100                 105                 110         


Ile Thr Leu Val Lys Ser Met Leu Phe Tyr Arg Lys Asn Pro Leu His 
        115                 120                 125             


Leu His Leu Val Thr Asp Ala Val Ala Arg Asn Ile Leu Glu Thr Leu 
    130                 135                 140                 


Phe His Thr Trp Met Val Pro Ala Val Arg Val Ser Phe Tyr His Ala 
145                 150                 155                 160 


Asp Gln Leu Lys Pro Gln Val Ser Trp Ile Pro Asn Lys His Tyr Ser 
                165                 170                 175     


Gly Leu Tyr Gly Leu Met Lys Leu Val Leu Pro Ser Ala Leu Pro Ala 
            180                 185                 190         


Glu Leu Ala Arg Val Ile Val Leu Asp Thr Asp Val Thr Phe Ala Ser 
        195                 200                 205             


Asp Ile Ser Glu Leu Trp Ala Leu Phe Ala His Phe Ser Asp Thr Gln 
    210                 215                 220                 


Ala Ile Gly Leu Val Glu Asn Gln Ser Asp Trp Tyr Leu Gly Asn Leu 
225                 230                 235                 240 


Trp Lys Asn His Arg Pro Trp Pro Ala Leu Gly Arg Gly Phe Asn Thr 
                245                 250                 255     


Gly Val Ile Leu Leu Arg Leu Asp Arg Leu Arg Gln Ala Gly Trp Glu 
            260                 265                 270         


Gln Met Trp Arg Leu Thr Ala Arg Arg Glu Leu Leu Ser Leu Pro Ala 
        275                 280                 285             


Thr Ser Leu Ala Asp Gln Asp Ile Phe Asn Ala Val Ile Lys Glu His 
    290                 295                 300                 


Pro Gly Leu Val Gln Arg Leu Pro Cys Val Trp Asn Val Gln Leu Ser 
305                 310                 315                 320 


Asp His Thr Leu Ala Glu Arg Cys Tyr Ser Glu Ala Ser Asp Leu Lys 
                325                 330                 335     


Val Ile His Trp Asn Ser Pro Lys Lys Leu Arg Val Lys Asn Lys His 
            340                 345                 350         


Val Glu Phe Phe Arg Asn Phe Tyr Leu Thr Phe Leu Glu Tyr Asp Gly 
        355                 360                 365             


Asn Leu Leu Arg Arg Glu Leu Phe Val Cys Pro Ser Gln Pro Pro Pro 
    370                 375                 380                 


Gly Ala Glu Gln Leu Gln Gln Ala Leu Ala Gln Leu Asp Glu Glu Asp 
385                 390                 395                 400 


Pro Cys Phe Glu Phe Arg Gln Gln Gln Leu Thr Val His Arg Val His 
                405                 410                 415     


Val Thr Phe Leu Pro His Glu Pro Pro Pro Pro Arg Pro His Asp Val 
            420                 425                 430         


Thr Leu Val Ala Gln Leu Ser Met Asp Arg Leu Gln Met Leu Glu Ala 
        435                 440                 445             


Leu Cys Arg His Trp Pro Gly Pro Met Ser Leu Ala Leu Tyr Leu Thr 
    450                 455                 460                 


Asp Ala Glu Ala Gln Gln Phe Leu His Phe Val Glu Ala Ser Pro Val 
465                 470                 475                 480 


Leu Ala Ala Arg Gln Asp Val Ala Tyr His Val Val Tyr Arg Glu Gly 
                485                 490                 495     


Pro Leu Tyr Pro Val Asn Gln Leu Arg Asn Val Ala Leu Ala Gln Ala 
            500                 505                 510         


Leu Thr Pro Tyr Val Phe Leu Ser Asp Ile Asp Phe Leu Pro Ala Tyr 
        515                 520                 525             


Ser Leu Tyr Asp Tyr Leu Arg Ala Ser Ile Glu Gln Leu Gly Leu Gly 
    530                 535                 540                 


Ser Arg Arg Lys Ala Ala Leu Val Val Pro Ala Phe Glu Thr Leu Arg 
545                 550                 555                 560 


Tyr Arg Phe Ser Phe Pro His Ser Lys Val Glu Leu Leu Ala Leu Leu 
                565                 570                 575     


Asp Ala Gly Thr Leu Tyr Thr Phe Arg Tyr His Glu Trp Pro Arg Gly 
            580                 585                 590         


His Ala Pro Thr Asp Tyr Ala Arg Trp Arg Glu Ala Gln Ala Pro Tyr 
        595                 600                 605             


Arg Val Gln Trp Ala Ala Asn Tyr Glu Pro Tyr Val Val Val Pro Arg 
    610                 615                 620                 


Asp Cys Pro Arg Tyr Asp Pro Arg Phe Val Gly Phe Gly Trp Asn Lys 
625                 630                 635                 640 


Val Ala His Ile Val Glu Leu Asp Ala Gln Glu Tyr Glu Leu Leu Val 
                645                 650                 655     


Leu Pro Glu Ala Phe Thr Ile His Leu Pro His Ala Pro Ser Leu Asp 
            660                 665                 670         


Ile Ser Arg Phe Arg Ser Ser Pro Thr Tyr Arg Asp Cys Leu Gln Ala 
        675                 680                 685             


Leu Lys Asp Glu Phe His Gln Asp Leu Ser Arg His His Gly Ala Ala 
    690                 695                 700                 


Ala Leu Lys Tyr Leu Pro Ala Leu Gln Gln Pro Gln Ser Pro Ala Arg 
705                 710                 715                 720 


Gly 
    


<210>  6031
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  6031

Met Glu Ala Ala Ala Thr Pro Ala Ala Ala Gly Ala Ala Arg Arg Glu 
1               5                   10                  15      


Glu Leu Asp Met Asp Val Met Arg Pro Leu Ile Asn Glu Gln Asn Phe 
            20                  25                  30          


Asp Gly Thr Ser Asp Glu Glu His Glu Gln Glu Leu Leu Pro Val Gln 
        35                  40                  45              


Lys His Tyr Gln Leu Asp Asp Gln Glu Gly Ile Ser Phe Val Gln Thr 
    50                  55                  60                  


Leu Met His Leu Leu Lys Gly Asn Ile Gly Thr Gly Leu Leu Gly Leu 
65                  70                  75                  80  


Pro Leu Ala Ile Lys Asn Ala Gly Ile Val Leu Gly Pro Ile Ser Leu 
                85                  90                  95      


Val Phe Ile Gly Ile Ile Ser Val His Cys Met His Ile Leu Val Arg 
            100                 105                 110         


Cys Ser His Phe Leu Cys Leu Arg Phe Lys Lys Ser Thr Leu Gly Tyr 
        115                 120                 125             


Ser Asp Thr Val Ser Phe Ala Met Glu Val Ser Pro Trp Ser Cys Leu 
    130                 135                 140                 


Gln Lys Gln Ala Ala Trp Gly Arg Ser Val Val Asp Phe Phe Leu Val 
145                 150                 155                 160 


Ile Thr Gln Leu Gly Phe Cys Ser Val Tyr Ile Val Phe Leu Ala Glu 
                165                 170                 175     


Asn Val Lys Gln Val His Glu Gly Phe Leu Glu Ser Lys Val Phe Ile 
            180                 185                 190         


Ser Asn Ser Thr Asn Ser Ser Asn Pro Cys Glu Arg Arg Ser Val Asp 
        195                 200                 205             


Leu Arg Ile Tyr Met Leu Cys Phe Leu Pro Phe Ile Ile Leu Leu Val 
    210                 215                 220                 


Phe Ile Arg Glu Leu Lys Asn Leu Phe Val Leu Ser Phe Leu Ala Asn 
225                 230                 235                 240 


Val Ser Met Ala Val Ser Leu Val Ile Ile Tyr Gln Tyr Val Val Arg 
                245                 250                 255     


Asn Met Pro Asp Pro His Asn Leu Pro Ile Val Ala Gly Trp Lys Lys 
            260                 265                 270         


Tyr Pro Leu Phe Phe Gly Thr Ala Val Phe Ala Phe Glu Gly Ile Gly 
        275                 280                 285             


Val Val Leu Pro Leu Glu Asn Gln Met Lys Glu Ser Lys Arg Phe Pro 
    290                 295                 300                 


Gln Ala Leu Asn Ile Gly Met Gly Ile Val Thr Thr Leu Tyr Val Thr 
305                 310                 315                 320 


Leu Ala Thr Leu Gly Tyr Met Cys Phe His Asp Glu Ile Lys Gly Ser 
                325                 330                 335     


Ile Thr Leu Asn Leu Pro Gln Asp Val Trp Leu Tyr Gln Ser Val Lys 
            340                 345                 350         


Ile Leu Tyr Ser Phe Gly Ile Phe Val Thr Tyr Ser Ile Gln Phe Tyr 
        355                 360                 365             


Val Pro Ala Glu Ile Ile Ile Pro Gly Ile Thr Ser Lys Phe His Thr 
    370                 375                 380                 


Lys Trp Lys Gln Ile Cys Glu Phe Gly Ile Arg Ser Phe Leu Val Ser 
385                 390                 395                 400 


Ile Thr Cys Ala Gly Ala Ile Leu Ile Pro Arg Leu Asp Ile Val Ile 
                405                 410                 415     


Ser Phe Val Gly Ala Val Ser Ser Ser Thr Leu Ala Leu Ile Leu Pro 
            420                 425                 430         


Pro Leu Val Glu Ile Leu Thr Phe Ser Lys Glu His Tyr Asn Ile Trp 
        435                 440                 445             


Met Val Leu Lys Asn Ile Ser Ile Ala Phe Thr Gly Val Val Gly Phe 
    450                 455                 460                 


Leu Leu Gly Thr Tyr Ile Thr Val Glu Glu Ile Ile Tyr Pro Thr Pro 
465                 470                 475                 480 


Lys Val Val Ala Gly Thr Pro Gln Ser Pro Phe Leu Asn Leu Asn Ser 
                485                 490                 495     


Thr Cys Leu Thr Ser Gly Leu Lys 
            500                 


<210>  6032
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  6032

Met Ser Ser Pro Ala Leu Thr Ala Gly Ala Ser Gly Lys Val Met Asp 
1               5                   10                  15      


Phe Asn Asn Gly Thr Tyr Leu Val Ser Phe Thr Leu Phe Trp Glu Gly 
            20                  25                  30          


Gln Val Ser Leu Ser Leu Leu Leu Ile His Pro Ser Glu Gly Ala Ser 
        35                  40                  45              


Ala Leu Trp Arg Ala Arg Asn Gln Gly Tyr Asp Lys Ile Ile Phe Lys 
    50                  55                  60                  


Gly Lys Phe Val Asn Gly Thr Ser His Val Phe Thr Glu Cys Gly Leu 
65                  70                  75                  80  


Thr Leu Asn Ser Asn Ala Glu Leu Cys Glu Tyr Leu Asp Asp Arg Asp 
                85                  90                  95      


Gln Glu Ala Phe Tyr Cys Met Lys Pro Gln His Met Pro Cys Glu Ala 
            100                 105                 110         


Leu Thr Tyr Met Thr Thr Arg Asn Arg Glu Val Ser Tyr Leu Thr Asp 
        115                 120                 125             


Lys Glu Asn Ser Leu Phe His Arg Ser Lys Val Gly Val Glu Met Met 
    130                 135                 140                 


Lys Asp Arg Lys His Ile Asp Val Thr Asn Cys Asn Lys Arg Glu Lys 
145                 150                 155                 160 


Ile Glu Glu Thr Cys Gln Val Gly Met Lys Pro Pro Val Pro Gly Gly 
                165                 170                 175     


Tyr Thr Leu Gln Gly Lys Trp Ile Thr Thr Phe Cys Asn Gln Val Gln 
            180                 185                 190         


Leu Asp Thr Ile Lys Ile Asn Gly Cys Leu Lys Gly Lys Leu Ile Tyr 
        195                 200                 205             


Leu Leu Gly Asp Ser Thr Leu Arg Gln Trp Ile Tyr Tyr Phe Pro Lys 
    210                 215                 220                 


Val Val Lys Thr Leu Lys Phe Phe Asp Leu His Glu Thr Gly Ile Phe 
225                 230                 235                 240 


Lys Lys His Leu Leu Leu Asp Ala Glu Arg His Thr Gln Ile Gln Trp 
                245                 250                 255     


Lys Lys His Ser Tyr Pro Phe Val Thr Phe Gln Leu Tyr Ser Leu Ile 
            260                 265                 270         


Asp His Asp Tyr Ile Pro Arg Glu Ile Asp Arg Leu Ser Gly Asp Lys 
        275                 280                 285             


Asn Thr Ala Ile Val Ile Thr Phe Gly Gln His Phe Arg Pro Phe Pro 
    290                 295                 300                 


Ile Asp Ile Phe Ile Arg Arg Ala Ile Gly Val Gln Lys Ala Ile Glu 
305                 310                 315                 320 


Arg Leu Phe Leu Arg Ser Pro Ala Thr Lys Val Ile Ile Lys Thr Glu 
                325                 330                 335     


Asn Ile Arg Glu Met His Ile Glu Thr Glu Arg Phe Gly Asp Phe His 
            340                 345                 350         


Gly Tyr Ile His Tyr Leu Ile Met Lys Asp Ile Phe Lys Asp Leu Asn 
        355                 360                 365             


Val Gly Ile Ile Asp Ala Trp Asp Met Thr Ile Ala Tyr Gly Thr Asp 
    370                 375                 380                 


Thr Ile His Pro Pro Asp His Val Ile Gly Asn Gln Ile Asn Met Phe 
385                 390                 395                 400 


Leu Asn Tyr Ile Cys 
                405 


<210>  6033
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  6033

Met Glu Tyr Val Leu Glu Val Lys Asn Ser Pro Arg His Leu Leu Lys 
1               5                   10                  15      


Gln Phe Thr Val Cys Asp Val Pro Leu Tyr Asp Ile Cys Asp Tyr Asn 
            20                  25                  30          


Val Ser Arg Asp Arg Cys Gln Glu Leu Gly Cys Cys Phe Tyr Glu Gly 
        35                  40                  45              


Val Cys Tyr Lys Lys Ala Val Pro Ile Tyr Ile His Val Phe Ser Ala 
    50                  55                  60                  


Leu Ile Val Ile Ile Ala Gly Ala Phe Val Ile Thr Ile Ile Tyr Arg 
65                  70                  75                  80  


Val Ile Gln Glu Ser Arg Lys Glu Lys Ala Ile Pro Val Asp Val Ala 
                85                  90                  95      


Leu Pro Gln Lys Ser Ser Glu Lys Ala Glu Leu Ala Ser Ser Ser Ser 
            100                 105                 110         


Lys Leu Gly Leu Lys Pro Ala Ser Pro Gly Pro Pro Ser Ala Gly Pro 
        115                 120                 125             


Ser Met Lys Ser Asp Glu Asp Lys Asp Asp Val Thr Gly Thr Ile Thr 
    130                 135                 140                 


Glu Ala Glu Glu Thr Glu Asp 
145                 150     


<210>  6034
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  6034

Met Ser Gly Thr Arg Ala Ser Asn Asp Arg Pro Pro Gly Ala Gly Gly 
1               5                   10                  15      


Val Lys Arg Gly Arg Leu Gln Gln Glu Ala Ala Ala Thr Gly Ser Arg 
            20                  25                  30          


Val Thr Val Val Leu Gly Ala Gln Trp Gly Asp Glu Gly Lys Gly Lys 
        35                  40                  45              


Val Val Asp Leu Leu Ala Thr Asp Ala Asp Ile Ile Ser Arg Cys Gln 
    50                  55                  60                  


Gly Gly Asn Asn Ala Gly His Thr Val Val Val Asp Gly Lys Glu Tyr 
65                  70                  75                  80  


Asp Phe His Leu Leu Pro Ser Gly Ile Ile Asn Thr Lys Ala Val Ser 
                85                  90                  95      


Phe Ile Gly Asn Gly Val Val Ile His Leu Pro Gly Leu Phe Glu Glu 
            100                 105                 110         


Ala Glu Lys Asn Glu Lys Lys Gly Leu Lys Asp Trp Glu Lys Arg Leu 
        115                 120                 125             


Ile Ile Ser Asp Arg Ala His Leu Val Phe Asp Phe His Gln Ala Val 
    130                 135                 140                 


Asp Gly Leu Gln Glu Val Gln Arg Gln Ala Gln Glu Gly Lys Asn Ile 
145                 150                 155                 160 


Gly Thr Thr Lys Lys Gly Ile Gly Pro Thr Tyr Ser Ser Lys Ala Ala 
                165                 170                 175     


Arg Thr Gly Leu Arg Ile Cys Asp Leu Leu Ser Asp Phe Asp Glu Phe 
            180                 185                 190         


Ser Ser Arg Phe Lys Asn Leu Ala His Gln His Gln Ser Met Phe Pro 
        195                 200                 205             


Thr Leu Glu Ile Asp Ile Glu Gly Gln Leu Lys Arg Leu Lys Gly Phe 
    210                 215                 220                 


Ala Glu Arg Ile Arg Pro Met Val Arg Asp Gly Val Tyr Phe Met Tyr 
225                 230                 235                 240 


Glu Ala Leu His Gly Pro Pro Lys Lys Ile Leu Val Glu Gly Ala Asn 
                245                 250                 255     


Ala Ala Leu Leu Asp Ile Asp Phe Gly Thr Tyr Pro Phe Val Thr Ser 
            260                 265                 270         


Ser Asn Cys Thr Val Gly Gly Val Cys Thr Gly Leu Gly Ile Pro Pro 
        275                 280                 285             


Gln Asn Ile Gly Asp Val Tyr Gly Val Val Lys Ala Tyr Thr Thr Arg 
    290                 295                 300                 


Val Gly Ile Gly Ala Phe Pro Thr Glu Gln Ile Asn Glu Ile Gly Gly 
305                 310                 315                 320 


Leu Leu Gln Thr Arg Gly His Glu Trp Gly Val Thr Thr Gly Arg Lys 
                325                 330                 335     


Arg Arg Cys Gly Trp Leu Asp Leu Met Ile Leu Arg Tyr Ala His Met 
            340                 345                 350         


Val Asn Gly Phe Thr Ala Leu Ala Leu Thr Lys Leu Asp Ile Leu Asp 
        355                 360                 365             


Val Leu Gly Glu Val Lys Val Gly Val Ser Tyr Lys Leu Asn Gly Lys 
    370                 375                 380                 


Arg Ile Pro Tyr Phe Pro Ala Asn Gln Glu Met Leu Gln Lys Val Glu 
385                 390                 395                 400 


Val Glu Tyr Glu Thr Leu Pro Gly Trp Lys Ala Asp Thr Thr Gly Ala 
                405                 410                 415     


Arg Arg Trp Glu Asp Leu Pro Pro Gln Ala Gln Asn Tyr Ile Arg Phe 
            420                 425                 430         


Val Glu Asn His Val Gly Val Ala Val Lys Trp Val Gly Val Gly Lys 
        435                 440                 445             


Ser Arg Glu Ser Met Ile Gln Leu Phe 
    450                 455         


<210>  6035
<211>  531
<212>  PRT
<213>  Homo sapiens

<400>  6035

Met Ala Val Ala Pro Ser Phe Asn Met Thr Asn Pro Gln Pro Ala Ile 
1               5                   10                  15      


Glu Gly Gly Ile Ser Glu Val Glu Ile Ile Ser Gln Gln Val Asp Glu 
            20                  25                  30          


Glu Thr Lys Ser Ile Ala Pro Val Gln Leu Val Asn Phe Ala Tyr Arg 
        35                  40                  45              


Asp Leu Pro Leu Ala Ala Val Asp Leu Ser Thr Ala Gly Ser Gln Leu 
    50                  55                  60                  


Leu Ser Asn Leu Asp Glu Asp Tyr Gln Arg Glu Gly Ser Asn Trp Leu 
65                  70                  75                  80  


Lys Pro Cys Cys Gly Lys Arg Ala Ala Val Trp Gln Val Phe Leu Leu 
                85                  90                  95      


Ser Ala Ser Leu Asn Ser Phe Leu Val Ala Cys Val Ile Leu Val Val 
            100                 105                 110         


Ile Leu Leu Thr Leu Glu Leu Leu Ile Asp Ile Lys Leu Leu Gln Phe 
        115                 120                 125             


Ser Ser Ala Phe Gln Phe Ala Gly Val Ile His Trp Ile Ser Leu Val 
    130                 135                 140                 


Ile Leu Ser Val Phe Phe Ser Glu Thr Val Leu Arg Ile Val Val Leu 
145                 150                 155                 160 


Gly Ile Trp Asp Tyr Ile Glu Asn Lys Ile Glu Val Phe Asp Gly Ala 
                165                 170                 175     


Val Ile Ile Leu Ser Leu Ala Pro Met Val Ala Ser Thr Val Ala Asn 
            180                 185                 190         


Gly Pro Arg Ser Pro Trp Asp Ala Ile Ser Leu Ile Ile Met Leu Arg 
        195                 200                 205             


Ile Trp Arg Val Lys Arg Val Ile Asp Ala Tyr Val Leu Pro Val Lys 
    210                 215                 220                 


Leu Glu Met Glu Met Val Ile Gln Gln Tyr Glu Lys Ala Lys Val Ile 
225                 230                 235                 240 


Gln Asp Glu Gln Leu Glu Arg Leu Thr Gln Ile Cys Gln Glu Gln Gly 
                245                 250                 255     


Phe Glu Ile Arg Gln Leu Arg Ala His Leu Ala Gln Gln Asp Leu Asp 
            260                 265                 270         


Leu Ala Ala Glu Arg Glu Ala Ala Leu Gln Ala Pro His Val Leu Ser 
        275                 280                 285             


Gln Pro Arg Ser Arg Phe Lys Val Leu Glu Ala Gly Thr Trp Asp Glu 
    290                 295                 300                 


Glu Thr Ala Ala Glu Ser Val Val Glu Glu Leu Gln Pro Ser Gln Glu 
305                 310                 315                 320 


Ala Thr Met Lys Asp Asp Met Asn Ser Tyr Ile Ser Gln Tyr Tyr Asn 
                325                 330                 335     


Gly Pro Ser Ser Asp Ser Gly Val Pro Glu Pro Ala Val Cys Met Val 
            340                 345                 350         


Thr Thr Ala Ala Ile Asp Ile His Gln Pro Asn Ile Ser Ser Asp Leu 
        355                 360                 365             


Phe Ser Leu Asp Met Pro Leu Lys Leu Gly Gly Asn Gly Thr Ser Ala 
    370                 375                 380                 


Thr Ser Glu Ser Ala Ser Arg Ser Ser Val Thr Arg Ala Gln Ser Asp 
385                 390                 395                 400 


Ser Ser Gln Thr Leu Gly Ser Ser Met Asp Cys Ser Thr Ala Arg Glu 
                405                 410                 415     


Glu Pro Ser Ser Glu Pro Gly Pro Ser Pro Pro Pro Leu Pro Ser Gln 
            420                 425                 430         


Gln Gln Val Glu Glu Ala Thr Val Gln Asp Leu Leu Ser Ser Leu Ser 
        435                 440                 445             


Glu Asp Pro Cys Pro Ser Gln Lys Ala Leu Asp Pro Ala Pro Leu Ala 
    450                 455                 460                 


Arg Pro Ser Pro Ala Gly Ser Ala Gln Thr Ser Pro Glu Leu Glu His 
465                 470                 475                 480 


Arg Val Ser Leu Phe Asn Gln Lys Asn Gln Glu Gly Phe Thr Val Phe 
                485                 490                 495     


Gln Ile Arg Pro Val Ile His Phe Gln Pro Thr Val Pro Met Leu Glu 
            500                 505                 510         


Asp Lys Phe Arg Ser Leu Glu Ser Lys Glu Gln Lys Leu His Arg Val 
        515                 520                 525             


Pro Glu Ala 
    530     


<210>  6036
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  6036

Met Ala Phe Leu Ala Gly Pro Arg Leu Leu Asp Trp Ala Ser Ser Pro 
1               5                   10                  15      


Pro His Leu Gln Phe Asn Lys Phe Val Leu Thr Gly Tyr Arg Pro Ala 
            20                  25                  30          


Ser Ser Gly Ser Gly Cys Leu Arg Ser Leu Phe Tyr Leu His Asn Glu 
        35                  40                  45              


Leu Gly Asn Ile Tyr Thr His Gly Leu Ala Leu Leu Gly Phe Leu Val 
    50                  55                  60                  


Leu Val Pro Met Thr Met Pro Trp Gly Gln Leu Gly Lys Asp Gly Trp 
65                  70                  75                  80  


Leu Gly Gly Thr His Cys Val Ala Cys Leu Ala Pro Pro Ala Gly Ser 
                85                  90                  95      


Val Leu Tyr His Leu Phe Met Cys His Gln Gly Gly Ser Ala Val Tyr 
            100                 105                 110         


Ala Arg Leu Leu Ala Leu Asp Met Cys Gly Val Cys Leu Val Asn Thr 
        115                 120                 125             


Leu Gly Ala Leu Pro Ile Ile His Cys Thr Leu Ala Cys Arg Pro Trp 
    130                 135                 140                 


Leu Arg Pro Ala Ala Leu Val Gly Tyr Thr Val Leu Ser Gly Val Ala 
145                 150                 155                 160 


Gly Trp Arg Ala Leu Thr Ala Pro Ser Thr Ser Ala Arg Leu Arg Ala 
                165                 170                 175     


Phe Gly Trp Gln Ala Ala Ala Arg Leu Leu Val Phe Gly Ala Arg Gly 
            180                 185                 190         


Val Gly Leu Gly Ser Gly Ala Pro Gly Ser Leu Pro Cys Tyr Leu Arg 
        195                 200                 205             


Met Asp Ala Leu Ala Leu Leu Gly Gly Leu Val Asn Val Ala Arg Leu 
    210                 215                 220                 


Pro Glu Arg Trp Gly Pro Gly Arg Phe Asp Tyr Trp Gly Asn Ser His 
225                 230                 235                 240 


Gln Ile Met His Leu Leu Ser Val Gly Ser Ile Leu Gln Leu His Ala 
                245                 250                 255     


Gly Val Val Pro Asp Leu Leu Trp Ala Ala His His Ala Cys Pro Arg 
            260                 265                 270         


Asp 
    


<210>  6037
<211>  569
<212>  PRT
<213>  Homo sapiens

<400>  6037

Met Ala Pro Thr Leu Ala Thr Ala His Arg Arg Arg Trp Trp Met Ala 
1               5                   10                  15      


Cys Thr Ala Val Leu Glu Asn Leu Leu Phe Ser Ala Val Leu Leu Gly 
            20                  25                  30          


Trp Gly Ser Leu Leu Ile Met Leu Lys Ser Glu Gly Phe Tyr Ser Tyr 
        35                  40                  45              


Leu Cys Thr Glu Pro Glu Asn Val Thr Asn Gly Thr Val Gly Gly Thr 
    50                  55                  60                  


Ala Glu Pro Gly His Glu Glu Val Ser Trp Met Asn Gly Trp Leu Ser 
65                  70                  75                  80  


Cys Gln Ala Gln Asp Glu Met Leu Asn Leu Ala Phe Thr Val Gly Ser 
                85                  90                  95      


Phe Leu Leu Ser Ala Ile Thr Leu Pro Leu Gly Ile Val Met Asp Lys 
            100                 105                 110         


Tyr Gly Pro Arg Lys Leu Arg Leu Leu Gly Ser Ala Cys Phe Ala Val 
        115                 120                 125             


Ser Cys Leu Leu Ile Ala Tyr Gly Ala Ser Lys Pro Asn Ala Leu Ser 
    130                 135                 140                 


Val Leu Ile Phe Ile Ala Leu Ala Leu Asn Gly Phe Gly Gly Met Cys 
145                 150                 155                 160 


Met Thr Phe Thr Ser Leu Thr Leu Pro Asn Met Phe Gly Asp Leu Arg 
                165                 170                 175     


Ser Thr Phe Ile Ala Leu Met Ile Gly Ser Tyr Ala Ser Ser Ala Val 
            180                 185                 190         


Thr Phe Pro Gly Ile Lys Leu Ile Tyr Asp Ala Gly Val Ser Phe Ile 
        195                 200                 205             


Val Val Leu Val Val Trp Ala Gly Cys Ser Gly Leu Val Phe Leu Asn 
    210                 215                 220                 


Cys Phe Phe Asn Trp Pro Leu Glu Pro Phe Pro Gly Pro Glu Asp Met 
225                 230                 235                 240 


Asp Tyr Ser Val Lys Ile Lys Phe Ser Trp Leu Gly Phe Asp His Lys 
                245                 250                 255     


Ile Thr Gly Lys Gln Phe Tyr Lys Gln Val Thr Thr Val Gly Arg Arg 
            260                 265                 270         


Leu Ser Val Gly Ser Ser Met Arg Ser Ala Lys Glu Gln Val Ala Leu 
        275                 280                 285             


Gln Glu Gly His Lys Leu Cys Leu Ser Thr Val Asp Leu Glu Val Lys 
    290                 295                 300                 


Cys Gln Pro Asp Ala Ala Val Ala Pro Ser Phe Met His Ser Val Phe 
305                 310                 315                 320 


Ser Pro Ile Leu Leu Leu Ser Leu Val Thr Met Cys Val Thr Gln Leu 
                325                 330                 335     


Arg Leu Ile Phe Tyr Met Gly Ala Met Asn Asn Ile Leu Lys Phe Leu 
            340                 345                 350         


Val Ser Gly Asp Gln Lys Thr Val Gly Leu Tyr Thr Ser Ile Phe Gly 
        355                 360                 365             


Val Leu Gln Leu Leu Cys Leu Leu Thr Ala Pro Val Ile Gly Tyr Ile 
    370                 375                 380                 


Met Asp Trp Arg Leu Lys Glu Cys Glu Asp Ala Ser Glu Glu Pro Glu 
385                 390                 395                 400 


Glu Lys Asp Ala Asn Gln Gly Glu Lys Lys Lys Lys Lys Arg Asp Arg 
                405                 410                 415     


Gln Ile Gln Lys Ile Thr Asn Ala Met Arg Ala Phe Ala Phe Thr Asn 
            420                 425                 430         


Leu Leu Leu Val Gly Phe Gly Val Thr Cys Leu Ile Pro Asn Leu Pro 
        435                 440                 445             


Leu Gln Ile Leu Ser Phe Ile Leu His Thr Ile Val Arg Gly Phe Ile 
    450                 455                 460                 


His Ser Ala Val Gly Gly Leu Tyr Ala Ala Val Tyr Pro Ser Thr Gln 
465                 470                 475                 480 


Phe Gly Ser Leu Thr Gly Leu Gln Ser Leu Ile Ser Ala Leu Phe Ala 
                485                 490                 495     


Leu Leu Gln Gln Pro Leu Phe Leu Ala Met Met Gly Pro Leu Gln Gly 
            500                 505                 510         


Asp Pro Leu Trp Val Asn Val Gly Leu Leu Leu Leu Ser Leu Leu Gly 
        515                 520                 525             


Phe Cys Leu Pro Leu Tyr Leu Ile Cys Tyr Arg Arg Gln Leu Glu Arg 
    530                 535                 540                 


Gln Leu Gln Gln Arg Gln Glu Asp Asp Lys Leu Phe Leu Lys Ile Asn 
545                 550                 555                 560 


Gly Ser Ser Asn Gln Glu Ala Phe Val 
                565                 


<210>  6038
<211>  612
<212>  PRT
<213>  Homo sapiens

<400>  6038

Met Ala Ala Asn Ser Thr Ser Asp Leu His Thr Pro Gly Thr Gln Leu 
1               5                   10                  15      


Ser Val Ala Asp Ile Ile Val Ile Thr Val Tyr Phe Ala Leu Asn Val 
            20                  25                  30          


Ala Val Gly Ile Trp Ser Ser Cys Arg Ala Ser Arg Asn Thr Val Asn 
        35                  40                  45              


Gly Tyr Phe Leu Ala Gly Arg Asp Met Thr Trp Trp Pro Ile Gly Ala 
    50                  55                  60                  


Ser Leu Phe Ala Ser Ser Glu Gly Ser Gly Leu Phe Ile Gly Leu Ala 
65                  70                  75                  80  


Gly Ser Gly Ala Ala Gly Gly Leu Ala Val Ala Gly Phe Glu Trp Asn 
                85                  90                  95      


Ala Thr Tyr Val Leu Leu Ala Leu Ala Trp Val Phe Val Pro Ile Tyr 
            100                 105                 110         


Ile Ser Ser Glu Ile Val Thr Leu Pro Glu Tyr Ile Gln Lys Arg Tyr 
        115                 120                 125             


Gly Gly Gln Arg Ile Arg Met Tyr Leu Ser Val Leu Ser Leu Leu Leu 
    130                 135                 140                 


Ser Val Phe Thr Lys Ile Ser Leu Asp Leu Tyr Ala Gly Ala Leu Phe 
145                 150                 155                 160 


Val His Ile Cys Leu Gly Trp Asn Phe Tyr Leu Ser Thr Ile Leu Thr 
                165                 170                 175     


Leu Gly Ile Thr Ala Leu Tyr Thr Ile Ala Gly Gly Leu Ala Ala Val 
            180                 185                 190         


Ile Tyr Thr Asp Ala Leu Gln Thr Leu Ile Met Val Val Gly Ala Val 
        195                 200                 205             


Ile Leu Thr Ile Lys Ala Phe Asp Gln Ile Gly Gly Tyr Gly Gln Leu 
    210                 215                 220                 


Glu Ala Ala Tyr Ala Gln Ala Ile Pro Ser Arg Thr Ile Ala Asn Thr 
225                 230                 235                 240 


Thr Cys His Leu Pro Arg Thr Asp Ala Met His Met Phe Arg Asp Pro 
                245                 250                 255     


His Thr Gly Asp Leu Pro Trp Thr Gly Met Thr Phe Gly Leu Thr Ile 
            260                 265                 270         


Met Ala Thr Trp Tyr Trp Cys Thr Asp Gln Val Ile Val Gln Arg Ser 
        275                 280                 285             


Leu Ser Ala Arg Asp Leu Asn His Ala Lys Ala Gly Ser Ile Leu Ala 
    290                 295                 300                 


Ser Tyr Leu Lys Met Leu Pro Met Gly Leu Ile Ile Met Pro Gly Met 
305                 310                 315                 320 


Ile Ser Arg Ala Leu Phe Pro Gly Ala His Val Tyr Glu Glu Arg His 
                325                 330                 335     


Gln Val Ser Val Ser Arg Thr Asp Asp Val Gly Cys Val Val Pro Ser 
            340                 345                 350         


Glu Cys Leu Arg Ala Cys Gly Ala Glu Val Gly Cys Ser Asn Ile Ala 
        355                 360                 365             


Tyr Pro Lys Leu Val Met Glu Leu Met Pro Ile Gly Leu Arg Gly Leu 
    370                 375                 380                 


Met Ile Ala Val Met Leu Ala Ala Leu Met Ser Ser Leu Thr Ser Ile 
385                 390                 395                 400 


Phe Asn Ser Ser Ser Thr Leu Phe Thr Met Asp Ile Trp Arg Arg Leu 
                405                 410                 415     


Arg Pro Arg Ser Gly Glu Arg Glu Leu Leu Leu Val Gly Arg Leu Val 
            420                 425                 430         


Ile Val Ala Leu Ile Gly Val Ser Val Ala Trp Ile Pro Val Leu Gln 
        435                 440                 445             


Asp Ser Asn Ser Gly Gln Leu Phe Ile Tyr Met Gln Ser Val Thr Ser 
    450                 455                 460                 


Ser Leu Ala Pro Pro Val Thr Ala Val Phe Val Leu Gly Val Phe Trp 
465                 470                 475                 480 


Arg Arg Ala Asn Glu Gln Gly Ala Phe Trp Gly Leu Ile Ala Gly Leu 
                485                 490                 495     


Val Val Gly Ala Thr Arg Leu Val Leu Glu Phe Leu Asn Pro Ala Pro 
            500                 505                 510         


Pro Cys Gly Glu Pro Asp Thr Arg Pro Ala Val Leu Gly Ser Ile His 
        515                 520                 525             


Tyr Leu His Phe Ala Val Ala Leu Phe Ala Leu Ser Gly Ala Val Val 
    530                 535                 540                 


Val Ala Gly Ser Leu Leu Thr Pro Pro Pro Gln Ser Val Gln Ile Glu 
545                 550                 555                 560 


Asn Leu Thr Trp Trp Thr Leu Ala Gln Asp Val Pro Leu Gly Thr Lys 
                565                 570                 575     


Ala Gly Asp Gly Gln Thr Pro Gln Lys His Ala Phe Trp Ala Arg Val 
            580                 585                 590         


Cys Gly Phe Asn Ala Ile Leu Leu Met Cys Val Asn Ile Phe Phe Tyr 
        595                 600                 605             


Ala Tyr Phe Ala 
    610         


<210>  6039
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  6039

Met Gln Trp Asn Val Pro Arg Thr Val Ser Arg Leu Ala Arg Arg Thr 
1               5                   10                  15      


Cys Leu Glu Pro His Asn Ala Gly Leu Phe Gly His Cys Gln Asn Val 
            20                  25                  30          


Lys Gly Pro Leu Leu Leu Tyr Asn Ala Glu Ser Lys Val Val Leu Val 
        35                  40                  45              


Gln Gly Pro Gln Lys Gln Trp Leu His Leu Ser Ala Ala Gln Cys Val 
    50                  55                  60                  


Ala Lys Glu Arg Arg Pro Leu Asp Ala His Pro Pro Gln Pro Gly Val 
65                  70                  75                  80  


Leu Arg His Lys Gln Gly Lys Gln His Val Ser Phe Arg Arg Val Phe 
                85                  90                  95      


Ser Ser Ser Ala Thr Ala Gln Gly Thr Pro Glu Lys Lys Glu Glu Pro 
            100                 105                 110         


Asp Pro Leu Gln Asp Lys Ser Ile Ser Leu Tyr Gln Arg Phe Lys Lys 
        115                 120                 125             


Thr Phe Arg Gln Tyr Gly Lys Val Leu Ile Pro Val His Leu Ile Thr 
    130                 135                 140                 


Ser Gly Val Trp Phe Gly Thr Phe Tyr Tyr Ala Ala Leu Lys Gly Val 
145                 150                 155                 160 


Asn Val Val Pro Phe Leu Glu Leu Ile Gly Leu Pro Asp Ser Val Val 
                165                 170                 175     


Ser Ile Leu Lys Asn Ser Gln Ser Gly Asn Ala Leu Thr Ala Tyr Ala 
            180                 185                 190         


Leu Phe Lys Ile Ala Thr Pro Ala Arg Tyr Thr Val Thr Leu Gly Gly 
        195                 200                 205             


Thr Ser Val Thr Val Lys Tyr Leu Arg Ser His Gly Tyr Met Ser Thr 
    210                 215                 220                 


Pro Pro Pro Val Lys Glu Tyr Leu Gln Asp Arg Met Glu Glu Thr Lys 
225                 230                 235                 240 


Glu Leu Ile Thr Glu Lys Met Glu Glu Thr Lys Asp Arg Leu Thr Glu 
                245                 250                 255     


Lys Leu Gln Glu Thr Lys Glu Lys Val Ser Phe Lys Lys Lys Val Glu 
            260                 265                 270         


<210>  6040
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  6040

Met Gly Val Lys Arg Ser Leu Gln Ser Gly Gly Ile Leu Leu Ser Leu 
1               5                   10                  15      


Val Ala Asn Val Leu Met Val Leu Ser Thr Ala Thr Asn Tyr Trp Thr 
            20                  25                  30          


Arg Gln Gln Glu Gly His Ser Gly Leu Trp Gln Glu Cys Asn His Gly 
        35                  40                  45              


Ile Cys Ser Ser Ile Pro Cys Gln Thr Thr Leu Ala Val Thr Val Ala 
    50                  55                  60                  


Cys Met Val Leu Ala Val Gly Val Gly Val Val Gly Met Val Met Gly 
65                  70                  75                  80  


Leu Arg Ile Arg Cys Asp Glu Gly Glu Ser Leu Arg Gly Gln Thr Thr 
                85                  90                  95      


Ser Ala Phe Leu Phe Leu Gly Gly Leu Leu Leu Leu Thr Ala Leu Ile 
            100                 105                 110         


Gly Tyr Thr Val Lys Asn Ala Trp Lys Asn Asn Val Phe Phe Ser Trp 
        115                 120                 125             


Ser Tyr Phe Ser Gly Trp Leu Ala Leu Pro Phe Ser Ile Leu Ala Gly 
    130                 135                 140                 


Phe Cys Phe Leu Leu Ala Asp Met Ile Met Gln Ser Thr Asp Ala Ile 
145                 150                 155                 160 


Ser Gly Phe Pro Val Cys Leu 
                165         


<210>  6041
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  6041

Met Pro Leu Ala Leu Thr Leu Leu Leu Leu Ser Gly Leu Gly Ala Pro 
1               5                   10                  15      


Gly Gly Trp Gly Cys Leu Gln Cys Asp Pro Leu Val Leu Glu Ala Leu 
            20                  25                  30          


Gly His Leu Arg Ser Ala Leu Ile Pro Ser Arg Phe Gln Leu Glu Gln 
        35                  40                  45              


Leu Gln Ala Arg Ala Gly Ala Val Leu Met Gly Met Glu Gly Pro Phe 
    50                  55                  60                  


Phe Arg Asp Tyr Ala Leu Asn Val Phe Val Gly Lys Val Glu Thr Asn 
65                  70                  75                  80  


Gln Leu Asp Leu Val Ala Ser Phe Val Lys Asn Gln Thr Gln His Leu 
                85                  90                  95      


Met Gly Asn Ser Leu Lys Asp Glu Pro Leu Leu Glu Glu Leu Val Thr 
            100                 105                 110         


Leu Arg Ala Asn Val Ile Lys Glu Phe Lys Lys Val Leu Ile Ser Tyr 
        115                 120                 125             


Glu Leu Lys Ala Cys Asn Pro Lys Leu Cys Arg Leu Leu Lys Glu Glu 
    130                 135                 140                 


Val Leu Asp Cys Leu His Cys Gln Arg Ile Thr Pro Lys Cys Ile His 
145                 150                 155                 160 


Lys Lys Tyr Cys Phe Val Asp Arg Gln Pro Arg Val Ala Leu Gln Tyr 
                165                 170                 175     


Gln Met Asp Ser Lys Tyr Pro Arg Asn Gln Ala Leu Leu Gly Ile Leu 
            180                 185                 190         


Ile Ser Val Ser Leu Ala Val Phe Val Phe Val Val Ile Val Val Ser 
        195                 200                 205             


Ala Cys Thr Tyr Arg Gln Asn Arg Lys Leu Leu Leu Gln 
    210                 215                 220     


<210>  6042
<211>  803
<212>  PRT
<213>  Homo sapiens

<400>  6042

Met Ala Glu Ala His Gln Ala Val Gly Phe Arg Pro Ser Leu Thr Ser 
1               5                   10                  15      


Asp Gly Ala Glu Val Glu Leu Ser Ala Pro Val Leu Gln Glu Ile Tyr 
            20                  25                  30          


Leu Ser Gly Leu Arg Ser Trp Lys Arg His Leu Ser Arg Phe Trp Asn 
        35                  40                  45              


Asp Phe Leu Thr Gly Val Phe Pro Ala Ser Pro Leu Ser Trp Leu Phe 
    50                  55                  60                  


Leu Phe Ser Ala Ile Gln Leu Ala Trp Phe Leu Gln Leu Asp Pro Ser 
65                  70                  75                  80  


Leu Gly Leu Met Glu Lys Ile Lys Glu Leu Leu Pro Asp Trp Gly Gly 
                85                  90                  95      


Gln His His Gly Leu Arg Gly Val Leu Ala Ala Ala Leu Phe Ala Ser 
            100                 105                 110         


Cys Leu Trp Gly Ala Leu Ile Phe Thr Leu His Val Ala Leu Arg Leu 
        115                 120                 125             


Leu Leu Ser Tyr His Gly Trp Leu Leu Glu Pro His Gly Ala Met Ser 
    130                 135                 140                 


Ser Pro Thr Lys Thr Trp Leu Ala Leu Val Arg Ile Phe Ser Gly Arg 
145                 150                 155                 160 


His Pro Met Leu Phe Ser Tyr Gln Arg Ser Leu Pro Arg Gln Pro Val 
                165                 170                 175     


Pro Ser Val Gln Asp Thr Val Arg Lys Tyr Leu Glu Ser Val Arg Pro 
            180                 185                 190         


Ile Leu Ser Asp Glu Asp Phe Asp Trp Thr Ala Val Leu Ala Gln Glu 
        195                 200                 205             


Phe Leu Arg Leu Gln Ala Ser Leu Leu Gln Trp Tyr Leu Arg Leu Lys 
    210                 215                 220                 


Ser Trp Trp Ala Ser Asn Tyr Val Ser Asp Trp Trp Glu Glu Phe Val 
225                 230                 235                 240 


Tyr Leu Arg Ser Arg Asn Pro Leu Met Val Asn Ser Asn Tyr Tyr Met 
                245                 250                 255     


Met Asp Phe Leu Tyr Val Thr Pro Thr Pro Leu Gln Ala Ala Arg Ala 
            260                 265                 270         


Gly Asn Ala Val His Ala Leu Leu Leu Tyr Arg His Arg Leu Asn Arg 
        275                 280                 285             


Gln Glu Ile Pro Pro Thr Leu Leu Met Gly Met Arg Pro Leu Cys Ser 
    290                 295                 300                 


Ala Gln Tyr Glu Lys Ile Phe Asn Thr Thr Arg Ile Pro Gly Val Gln 
305                 310                 315                 320 


Lys Asp Tyr Ile Arg His Leu His Asp Ser Gln His Val Ala Val Phe 
                325                 330                 335     


His Arg Gly Arg Phe Phe Arg Met Gly Thr His Ser Arg Asn Ser Leu 
            340                 345                 350         


Leu Ser Pro Arg Ala Leu Glu Gln Gln Phe Gln Arg Ile Leu Asp Asp 
        355                 360                 365             


Pro Ser Pro Ala Cys Pro His Glu Glu His Leu Ala Ala Leu Thr Ala 
    370                 375                 380                 


Ala Pro Arg Gly Thr Trp Ala Gln Val Arg Thr Ser Leu Lys Thr Gln 
385                 390                 395                 400 


Ala Ala Glu Ala Leu Glu Ala Val Glu Gly Ala Ala Phe Phe Val Ser 
                405                 410                 415     


Leu Asp Ala Glu Pro Ala Gly Leu Thr Arg Glu Asp Pro Ala Ala Ser 
            420                 425                 430         


Leu Asp Ala Tyr Ala His Ala Leu Leu Ala Gly Arg Gly His Asp Arg 
        435                 440                 445             


Trp Phe Asp Lys Ser Phe Thr Leu Ile Val Phe Ser Asn Gly Lys Leu 
    450                 455                 460                 


Gly Leu Ser Val Glu His Ser Trp Ala Asp Cys Pro Ile Ser Gly His 
465                 470                 475                 480 


Met Trp Glu Phe Thr Leu Ala Thr Glu Cys Phe Gln Leu Gly Tyr Ser 
                485                 490                 495     


Thr Asp Gly His Cys Lys Gly His Pro Asp Pro Thr Leu Pro Gln Pro 
            500                 505                 510         


Gln Arg Leu Gln Trp Asp Leu Pro Asp Gln Ile His Ser Ser Ile Ser 
        515                 520                 525             


Leu Ala Leu Arg Gly Ala Lys Ile Leu Ser Glu Asn Val Asp Cys His 
    530                 535                 540                 


Val Val Pro Phe Ser Leu Phe Gly Lys Ser Phe Ile Arg Arg Cys His 
545                 550                 555                 560 


Leu Ser Ser Asp Ser Phe Ile Gln Ile Ala Leu Gln Leu Ala His Phe 
                565                 570                 575     


Arg Asp Arg Gly Gln Phe Cys Leu Thr Tyr Glu Ser Ala Met Thr Arg 
            580                 585                 590         


Leu Phe Leu Glu Gly Arg Thr Glu Thr Val Arg Ser Cys Thr Arg Glu 
        595                 600                 605             


Ala Cys Asn Phe Val Arg Ala Met Glu Asp Lys Glu Lys Thr Asp Pro 
    610                 615                 620                 


Gln Cys Leu Ala Leu Phe Arg Val Ala Val Asp Lys His Gln Ala Leu 
625                 630                 635                 640 


Leu Lys Ala Ala Met Ser Gly Gln Gly Val Asp Arg His Leu Phe Ala 
                645                 650                 655     


Leu Tyr Ile Val Ser Arg Phe Leu His Leu Gln Ser Pro Phe Leu Thr 
            660                 665                 670         


Gln Val His Ser Glu Gln Trp Gln Leu Ser Thr Ser Gln Ile Pro Val 
        675                 680                 685             


Gln Gln Met His Leu Phe Asp Val His Asn Tyr Pro Asp Tyr Val Ser 
    690                 695                 700                 


Ser Gly Gly Gly Phe Gly Pro Ala Asp Asp His Gly Tyr Gly Val Ser 
705                 710                 715                 720 


Tyr Ile Phe Met Gly Asp Gly Met Ile Thr Phe His Ile Ser Ser Lys 
                725                 730                 735     


Lys Ser Ser Thr Lys Thr Asp Ser His Arg Leu Gly Gln His Ile Glu 
            740                 745                 750         


Asp Ala Leu Leu Asp Val Ala Ser Leu Phe Gln Ala Gly Gln His Phe 
        755                 760                 765             


Lys Arg Arg Phe Arg Gly Ser Gly Lys Glu Asn Ser Arg His Arg Cys 
    770                 775                 780                 


Gly Phe Leu Ser Arg Gln Thr Gly Ala Ser Lys Ala Ser Met Thr Ser 
785                 790                 795                 800 


Thr Asp Phe 
            


<210>  6043
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  6043

Met Trp Thr Pro Val Arg Arg Gly Ala Ala Trp Leu Gly Thr Leu Leu 
1               5                   10                  15      


Gly Pro Gly Glu Gly Pro Pro Glu Pro Arg Gly Gly Ala Ala His Ala 
            20                  25                  30          


His Lys Pro Pro Ala Gly Ser Arg Lys Ser Thr Asp Gln Ala Val Arg 
        35                  40                  45              


Phe Gly Pro Ser Gln Gly Met Cys Ser Glu Ala Arg Leu Ala Arg Arg 
    50                  55                  60                  


Leu Arg Asp Ala Leu Arg Glu Glu Glu Pro Trp Ala Val Glu Glu Leu 
65                  70                  75                  80  


Leu Arg Cys Gly Ala Asp Pro Asn Leu Val Leu Glu Asp Gly Ala Ala 
                85                  90                  95      


Ala Val His Leu Ala Ala Gly Ala Arg His Pro Arg Gly Leu Arg Cys 
            100                 105                 110         


Leu Gly Ala Leu Leu Arg Gln Gly Gly Asp Pro Asn Ala Arg Ser Val 
        115                 120                 125             


Glu Ala Leu Thr Pro Leu His Val Ala Ala Ala Trp Gly Cys Arg Arg 
    130                 135                 140                 


Gly Leu Glu Leu Leu Leu Ser Gln Gly Ala Asp Pro Ala Leu Arg Asp 
145                 150                 155                 160 


Gln Asp Gly Leu Arg Pro Leu Asp Leu Ala Leu Gln Gln Gly His Leu 
                165                 170                 175     


Glu Cys Ala Arg Val Leu Gln Asp Leu Asp Thr Arg Thr Arg Thr Arg 
            180                 185                 190         


Thr Arg Ile Gly Ala Glu Thr Gln Glu Pro Glu Pro Ala Pro Gly Thr 
        195                 200                 205             


Pro Gly Leu Ser Gly Pro Thr Asp Glu Thr Leu Asp Ser Ile Ala Leu 
    210                 215                 220                 


Gln Lys Gln Pro Cys Arg Gly Asp Asn Arg Asp Ile Gly Leu Glu Ala 
225                 230                 235                 240 


Asp Pro Gly Pro Pro Ser Leu Pro Val Pro Leu Glu Thr Val Asp Lys 
                245                 250                 255     


His Gly Ser Ser Ala Ser Pro Pro Gly His Trp Asp Tyr Ser Ser Asp 
            260                 265                 270         


Ala Ser Phe Val Thr Ala Val Glu Val Ser Gly Ala Glu Asp Pro Ala 
        275                 280                 285             


Ser Asp Thr Pro Pro Trp Ala Gly Ser Leu Pro Pro Thr Arg Gln Gly 
    290                 295                 300                 


Leu Leu His Val Val His Ala Asn Gln Arg Val Pro Arg Ser Gln Gly 
305                 310                 315                 320 


Thr Glu Ala Glu Leu Asn Ala Arg Leu Gln Ala Leu Thr Leu Thr Pro 
                325                 330                 335     


Pro Asn Ala Ala Gly Phe Gln Ser Ser Pro Ser Ser Met Pro Leu Leu 
            340                 345                 350         


Asp Arg Ser Pro Ala His Ser Pro Pro Arg Thr Pro Thr Pro Gly Ala 
        355                 360                 365             


Ser Asp Cys His Cys Leu Trp Glu His Gln Thr Ser Ile Asp Ser Asp 
    370                 375                 380                 


Met Ala Thr Leu Trp Leu Thr Glu Asp Glu Ala Ser Ser Thr Gly Gly 
385                 390                 395                 400 


Arg Glu Pro Val Gly Pro Cys Arg His Leu Pro Val Ser Thr Val Ser 
                405                 410                 415     


Asp Leu Glu Leu Leu Lys Gly Leu Arg Ala Leu Gly Glu Asn Pro His 
            420                 425                 430         


Pro Ile Thr Pro Phe Thr Arg Gln Leu Tyr His Gln Gln Leu Glu Glu 
        435                 440                 445             


Ala Gln Ile Ala Pro Gly Pro Glu Phe Ser Gly His Ser Leu Glu Leu 
    450                 455                 460                 


Ala Ala Ala Leu Arg Thr Gly Cys Ile Pro Asp Val Gln Ala Asp Glu 
465                 470                 475                 480 


Asp Ala Leu Ala Gln Gln Phe Glu Gln Pro Asp Pro Ala Arg Arg Trp 
                485                 490                 495     


Arg Glu Gly Val Val Lys Ser Ser Phe Thr Tyr Leu Leu Leu Asp Pro 
            500                 505                 510         


Arg Glu Thr Gln Asp Leu Pro Ala Arg Ala Phe Ser Leu Thr Pro Ala 
        515                 520                 525             


Glu Arg Leu Gln Thr Phe Ile Arg Ala Ile Phe Tyr Val Gly Lys Gly 
    530                 535                 540                 


Thr Arg Ala Arg Pro Tyr Val His Leu Trp Glu Ala Leu Gly His His 
545                 550                 555                 560 


Gly Arg Ser Arg Lys Gln Pro His Gln Ala Cys Pro Lys Val Arg Gln 
                565                 570                 575     


Ile Leu Asp Ile Trp Ala Ser Gly Cys Gly Val Val Ser Leu His Cys 
            580                 585                 590         


Phe Gln His Val Val Ala Val Glu Ala Tyr Thr Arg Glu Ala Cys Ile 
        595                 600                 605             


Val Glu Ala Leu Gly Ile Gln Thr Leu Thr Asn Gln Lys Gln Gly His 
    610                 615                 620                 


Cys Tyr Gly Val Val Ala Gly Trp Pro Pro Ala Arg Arg Arg Arg Leu 
625                 630                 635                 640 


Gly Val His Leu Leu His Arg Ala Leu Leu Val Phe Leu Ala Glu Gly 
                645                 650                 655     


Glu Arg Gln Leu His Pro Gln Asp Ile Gln Ala Arg Gly 
            660                 665                 


<210>  6044
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  6044

Met Gly Tyr Ser Val Val Ala Gly Ala Ala Gly Arg Leu Leu Phe Gly 
1               5                   10                  15      


Tyr Asp Ser Phe Gly Asn Met Cys Gly Lys Lys Asn Ser Pro Val Glu 
            20                  25                  30          


Gly Ala Pro Leu Ser Gly Gln Asp Met Thr Leu Lys Lys His Val Phe 
        35                  40                  45              


Phe Met Asn Ser Cys Asn Leu Glu Val Lys Gly Thr Gln Leu Asn Arg 
    50                  55                  60                  


Met Ala Leu Cys Val Ser Asn Cys Pro Glu Glu Gln Leu Asp Ser Leu 
65                  70                  75                  80  


Glu Glu Val Gln Phe Phe Ala Asn Thr Ser Gly Ser Phe Leu Cys Val 
                85                  90                  95      


Tyr Ser Leu Asn Ser Phe Asn Tyr Thr His Ser Pro Lys Ala Asp Ser 
            100                 105                 110         


Leu Cys Pro Arg Leu Pro Val Pro Pro Ser Lys Ser Phe Pro Leu Phe 
        115                 120                 125             


Asn Arg Cys Val Pro Gln Thr Pro Glu Cys Tyr Ser Leu Phe Ala Ser 
    130                 135                 140                 


Val Leu Ile Asn Asp Val Asp Thr Leu His Arg Ile Leu Ser Gly Ile 
145                 150                 155                 160 


Met Ser Gly Arg Asp Thr Ile Leu Gly Leu Cys Ile Leu Ala Leu Ala 
                165                 170                 175     


Leu Ser Leu Ala Met Met Phe Thr Phe Arg Phe Ile Thr Thr Leu Leu 
            180                 185                 190         


Val His Ile Phe Ile Ser Leu Val Ile Leu Gly Leu Leu Phe Val Cys 
        195                 200                 205             


Gly Val Leu Trp Trp Leu Tyr Tyr Asp Tyr Thr Asn Asp Leu Ser Ile 
    210                 215                 220                 


Glu Leu Asp Thr Glu Arg Glu Asn Met Lys Cys Val Leu Gly Phe Ala 
225                 230                 235                 240 


Ile Val Ser Thr Gly Ile Thr Ala Val Leu Leu Val Leu Ile Phe Val 
                245                 250                 255     


Leu Arg Lys Arg Ile Lys Leu Thr Val Glu Leu Phe Gln Ile Thr Asn 
            260                 265                 270         


Lys Ala Ile Ser Ser Ala Pro Phe Leu Leu Phe Gln Pro Leu Trp Thr 
        275                 280                 285             


Phe Ala Ile Leu Ile Phe Phe Trp Val Leu Trp Val Ala Val Leu Leu 
    290                 295                 300                 


Ser Leu Gly Thr Ala Gly Ala Ala Gln Val Met Glu Gly Gly Gln Val 
305                 310                 315                 320 


Glu Tyr Lys Pro Leu Ser Gly Ile Arg Tyr Met Trp Ser Tyr His Leu 
                325                 330                 335     


Ile Gly Leu Ile Trp Thr Ser Glu Phe Ile Leu Ala Cys Gln Gln Met 
            340                 345                 350         


Thr Ile Ala Gly Ala Val Val Thr Cys Tyr Phe Asn Arg Ser Lys Asn 
        355                 360                 365             


Asp Pro Pro Asp His Pro Ile Leu Ser Ser Leu Ser Ile Leu Phe Phe 
    370                 375                 380                 


Tyr His Gln Gly Thr Val Val Lys Gly Ser Phe Leu Ile Ser Val Val 
385                 390                 395                 400 


Arg Ile Pro Arg Ile Ile Val Met Tyr Met Gln Asn Ala Leu Lys Glu 
                405                 410                 415     


Gln Gln His Gly Ala Leu Ser Arg Tyr Leu Phe Arg Cys Cys Tyr Cys 
            420                 425                 430         


Cys Phe Trp Cys Leu Asp Lys Tyr Leu Leu His Leu Asn Gln Asn Ala 
        435                 440                 445             


Tyr Thr Thr Thr Ala Ile Asn Gly Thr Asp Phe Cys Thr Ser Ala Lys 
    450                 455                 460                 


Asp Ala Phe Lys Ile Leu Ser Lys Asn Ser Ser His Phe Thr Ser Ile 
465                 470                 475                 480 


Asn Cys Phe Gly Asp Phe Ile Ile Phe Leu Gly Lys Val Leu Val Val 
                485                 490                 495     


Cys Phe Thr Val Phe Gly Gly Leu Met Ala Phe Asn Tyr Asn Arg Ala 
            500                 505                 510         


Phe Gln Val Trp Ala Val Pro Leu Leu Leu Val Ala Phe Phe Ala Tyr 
        515                 520                 525             


Leu Val Ala His Ser Phe Leu Ser Val Phe Glu Thr Val Leu Asp Ala 
    530                 535                 540                 


Leu Phe Leu Cys Phe Ala Val Asp Leu Glu Thr Asn Asp Gly Ser Ser 
545                 550                 555                 560 


Glu Lys Pro Tyr Phe Met Asp Gln Glu Phe Leu Ser Phe Val Lys Arg 
                565                 570                 575     


Ser Asn Lys Leu Asn Asn Ala Arg Ala Gln Gln Asp Lys His Ser Leu 
            580                 585                 590         


Arg Asn Glu Glu Gly Thr Glu Leu Gln Ala Ile Val Arg 
        595                 600                 605 


<210>  6045
<211>  777
<212>  PRT
<213>  Homo sapiens

<400>  6045

Met Phe Pro Arg Gly Ala Glu Ala Gln Asp Trp His Leu Asp Met Gln 
1               5                   10                  15      


Leu Thr Gly Lys Val Val Leu Ser Ala Ala Ala Leu Leu Leu Val Thr 
            20                  25                  30          


Val Ala Tyr Arg Leu Tyr Lys Ser Arg Pro Ala Pro Ala Gln Arg Trp 
        35                  40                  45              


Gly Gly Asn Gly Gln Ala Glu Ala Lys Glu Glu Ala Glu Gly Ser Gly 
    50                  55                  60                  


Gln Pro Ala Val Gln Glu Ala Ser Pro Gly Val Leu Leu Arg Gly Pro 
65                  70                  75                  80  


Arg Arg Arg Arg Ser Ser Lys Arg Ala Glu Ala Pro Gln Gly Cys Ser 
                85                  90                  95      


Cys Glu Asn Pro Arg Gly Pro Tyr Val Leu Val Thr Gly Ala Thr Ser 
            100                 105                 110         


Thr Asp Arg Lys Pro Gln Arg Lys Gly Ser Gly Glu Glu Arg Gly Gly 
        115                 120                 125             


Gln Gly Ser Asp Ser Glu Gln Val Pro Pro Cys Cys Pro Ser Gln Glu 
    130                 135                 140                 


Thr Arg Thr Ala Val Gly Ser Asn Pro Asp Pro Pro His Phe Pro Arg 
145                 150                 155                 160 


Leu Gly Ser Glu Pro Lys Ser Ser Pro Ala Gly Leu Ile Ala Ala Ala 
                165                 170                 175     


Asp Gly Ser Cys Ala Gly Gly Glu Pro Ser Pro Trp Gln Asp Ser Lys 
            180                 185                 190         


Pro Arg Glu His Pro Gly Leu Gly Gln Leu Glu Pro Pro His Cys His 
        195                 200                 205             


Tyr Val Ala Pro Leu Gln Gly Ser Ser Asp Met Asn Gln Ser Trp Val 
    210                 215                 220                 


Phe Thr Arg Val Ile Gly Val Ser Arg Glu Glu Ala Gly Ala Leu Glu 
225                 230                 235                 240 


Ala Ala Ser Asp Val Asp Leu Thr Leu His Gln Gln Glu Gly Ala Pro 
                245                 250                 255     


Asn Ser Ser Tyr Thr Phe Ser Ser Ile Ala Arg Val Arg Met Glu Glu 
            260                 265                 270         


His Phe Ile Gln Lys Ala Glu Gly Val Glu Pro Arg Leu Lys Gly Lys 
        275                 280                 285             


Val Tyr Asp Tyr Tyr Val Glu Ser Thr Ser Gln Ala Ile Phe Gln Gly 
    290                 295                 300                 


Arg Leu Ala Pro Arg Thr Ala Ala Leu Thr Glu Val Pro Ser Pro Arg 
305                 310                 315                 320 


Pro Pro Pro Gly Ser Leu Gly Thr Gly Ala Ala Ser Gly Gly Gln Ala 
                325                 330                 335     


Gly Asp Thr Lys Gly Ala Ala Glu Arg Ala Ala Ser Pro Gln Thr Gly 
            340                 345                 350         


Pro Trp Pro Ser Thr Arg Gly Phe Ser Arg Lys Glu Ser Leu Leu Gln 
        355                 360                 365             


Ile Ala Glu Asn Pro Glu Leu Gln Leu Gln Pro Asp Gly Phe Arg Leu 
    370                 375                 380                 


Pro Ala Pro Pro Cys Pro Asp Pro Gly Ala Leu Pro Gly Leu Gly Arg 
385                 390                 395                 400 


Ser Ser Arg Glu Pro His Val Gln Pro Val Ala Gly Thr Asn Phe Phe 
                405                 410                 415     


His Ile Pro Leu Thr Pro Ala Ser Ala Pro Gln Val Arg Leu Asp Leu 
            420                 425                 430         


Gly Asn Cys Tyr Glu Val Leu Thr Leu Ala Lys Arg Gln Asn Leu Glu 
        435                 440                 445             


Ala Leu Lys Glu Ala Ala Tyr Lys Val Met Ser Glu Asn Tyr Leu Gln 
    450                 455                 460                 


Val Leu Arg Ser Pro Asp Ile Tyr Gly Cys Leu Ser Gly Ala Glu Arg 
465                 470                 475                 480 


Glu Leu Ile Leu Gln Arg Arg Leu Arg Gly Arg Gln Tyr Leu Val Val 
                485                 490                 495     


Ala Asp Val Cys Pro Lys Glu Asp Ser Gly Gly Leu Cys Cys Tyr Asp 
            500                 505                 510         


Asp Glu Gln Asp Val Trp Arg Pro Leu Ala Arg Met Pro Pro Glu Ala 
        515                 520                 525             


Val Ser Arg Gly Cys Ala Ile Cys Ser Leu Phe Asn Tyr Leu Phe Val 
    530                 535                 540                 


Val Ser Gly Cys Gln Gly Pro Gly His Gln Pro Ser Ser Arg Val Phe 
545                 550                 555                 560 


Cys Tyr Asn Pro Leu Thr Gly Ile Trp Ser Glu Val Cys Pro Leu Asn 
                565                 570                 575     


Gln Ala Arg Pro His Cys Arg Leu Val Ala Leu Asp Gly His Leu Tyr 
            580                 585                 590         


Ala Ile Gly Gly Glu Cys Leu Asn Ser Val Glu Arg Tyr Asp Pro Arg 
        595                 600                 605             


Leu Asp Arg Trp Asp Phe Ala Pro Pro Leu Pro Ser Asp Thr Phe Ala 
    610                 615                 620                 


Leu Ala His Thr Ala Thr Val Arg Ala Lys Glu Ile Phe Val Thr Gly 
625                 630                 635                 640 


Gly Ser Leu Arg Phe Leu Leu Phe Arg Phe Ser Ala Gln Glu Gln Arg 
                645                 650                 655     


Trp Trp Ala Gly Pro Thr Gly Gly Ser Lys Asp Arg Thr Ala Glu Met 
            660                 665                 670         


Val Ala Val Asn Gly Phe Leu Tyr Arg Phe Asp Leu Asn Arg Ser Leu 
        675                 680                 685             


Gly Ile Ala Val Tyr Arg Cys Ser Ala Ser Thr Arg Leu Trp Tyr Glu 
    690                 695                 700                 


Cys Ala Thr Tyr Arg Thr Pro Tyr Pro Asp Ala Phe Gln Cys Ala Val 
705                 710                 715                 720 


Val Asp Asn Leu Ile Tyr Cys Val Gly Arg Arg Ser Thr Leu Cys Phe 
                725                 730                 735     


Leu Ala Asp Ser Val Ser Pro Arg Phe Val Pro Lys Glu Leu Arg Ser 
            740                 745                 750         


Phe Pro Ala Pro Gln Gly Thr Leu Leu Pro Thr Val Leu Thr Leu Pro 
        755                 760                 765             


Thr Pro Asp Leu Pro Gln Thr Arg Val 
    770                 775         


<210>  6046
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  6046

Met Ala Glu Leu Leu Arg Ser Leu Gln Asp Ser Gln Leu Val Ala Arg 
1               5                   10                  15      


Phe Gln Arg Arg Cys Gly Leu Phe Pro Ala Pro Asp Glu Gly Pro Arg 
            20                  25                  30          


Glu Asn Gly Ala Asp Pro Thr Glu Arg Ala Ala Arg Val Pro Gly Val 
        35                  40                  45              


Glu His Leu Pro Ala Ala Asn Gly Lys Gly Gly Glu Ala Pro Ala Asn 
    50                  55                  60                  


Gly Leu Arg Arg Ala Ala Ala Pro Glu Ala Tyr Val Gln Lys Tyr Val 
65                  70                  75                  80  


Val Lys Asn Tyr Phe Tyr Tyr Tyr Leu Phe Gln Phe Ser Ala Ala Leu 
                85                  90                  95      


Gly Gln Glu Val Phe Tyr Ile Thr Phe Leu Pro Phe Thr His Trp Asn 
            100                 105                 110         


Ile Asp Pro Tyr Leu Ser Arg Arg Leu Ile Ile Ile Trp Val Leu Val 
        115                 120                 125             


Met Tyr Ile Gly Gln Val Ala Lys Asp Val Leu Lys Trp Pro Arg Pro 
    130                 135                 140                 


Ser Ser Pro Pro Val Val Lys Leu Glu Lys Arg Leu Ile Ala Glu Tyr 
145                 150                 155                 160 


Gly Met Pro Ser Thr His Ala Met Ala Ala Thr Ala Ile Ala Phe Thr 
                165                 170                 175     


Leu Leu Ile Ser Thr Met Asp Arg Tyr Gln Tyr Pro Phe Val Leu Gly 
            180                 185                 190         


Leu Val Met Ala Val Val Phe Ser Thr Leu Val Cys Leu Ser Arg Leu 
        195                 200                 205             


Tyr Thr Gly Met His Thr Val Leu Asp Val Leu Gly Gly Val Leu Ile 
    210                 215                 220                 


Thr Ala Leu Leu Ile Val Leu Thr Tyr Pro Ala Trp Thr Phe Ile Asp 
225                 230                 235                 240 


Cys Leu Asp Ser Ala Ser Pro Leu Phe Pro Val Cys Val Ile Val Val 
                245                 250                 255     


Pro Phe Phe Leu Cys Tyr Asn Tyr Pro Val Ser Asp Tyr Tyr Ser Pro 
            260                 265                 270         


Thr Arg Ala Asp Thr Thr Thr Ile Leu Ala Ala Gly Ala Gly Val Thr 
        275                 280                 285             


Ile Gly Phe Trp Ile Asn His Phe Phe Gln Leu Val Ser Lys Pro Ala 
    290                 295                 300                 


Glu Ser Leu Pro Val Ile Gln Asn Ile Pro Pro Leu Thr Thr Tyr Met 
305                 310                 315                 320 


Leu Val Leu Gly Leu Thr Lys Phe Ala Val Gly Ile Val Leu Ile Leu 
                325                 330                 335     


Leu Val Arg Gln Leu Val Gln Asn Leu Ser Leu Gln Val Leu Tyr Ser 
            340                 345                 350         


Trp Phe Lys Val Val Thr Arg Asn Lys Glu Ala Arg Arg Arg Leu Glu 
        355                 360                 365             


Ile Glu Val Pro Tyr Lys Phe Val Thr Tyr Thr Ser Val Gly Ile Cys 
    370                 375                 380                 


Ala Thr Thr Phe Val Pro Met Leu His Arg Phe Leu Gly Leu Pro 
385                 390                 395                 


<210>  6047
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  6047

Met Gly Lys Asn Pro Val Arg Pro Pro Arg Ala Leu Pro Pro Val Pro 
1               5                   10                  15      


Ser Gln Asp Asp Ile Pro Leu Ser Arg Pro Lys Lys Lys Lys Pro Arg 
            20                  25                  30          


Thr Lys Asn Thr Pro Ala Ser Ala Ser Leu Glu Gly Leu Ala Gln Thr 
        35                  40                  45              


Ala Gly Arg Arg Pro Ser Glu Gly Asn Glu Pro Ser Thr Lys Glu Leu 
    50                  55                  60                  


Lys Glu His Pro Glu Ala Pro Val Gln Arg Arg Gln Lys Lys Thr Arg 
65                  70                  75                  80  


Leu Pro Leu Glu Leu Glu Thr Ser Ser Thr Gln Lys Lys Ser Ser Ser 
                85                  90                  95      


Ser Ser Leu Leu Arg Asn Glu Asn Gly Ile Asp Ala Glu Pro Ala Glu 
            100                 105                 110         


Glu Ala Val Ile Gln Lys Pro Arg Arg Lys Thr Lys Lys Thr Gln Pro 
        115                 120                 125             


Ala Glu Leu Gln Tyr Ala Asn Glu Leu Gly Val Glu Asp Glu Asp Ile 
    130                 135                 140                 


Ile Thr Asp Glu Gln Thr Thr Val Glu Gln Gln Ser Val Phe Thr Ala 
145                 150                 155                 160 


Pro Thr Gly Ile Ser Gln Pro Val Gly Lys Val Phe Val Glu Lys Ser 
                165                 170                 175     


Arg Arg Phe Gln Ala Ala Asp Arg Ser Glu Leu Ile Lys Thr Thr Glu 
            180                 185                 190         


Asn Ile Asp Val Ser Met Asp Val Lys Pro Ser Trp Thr Thr Arg Asp 
        195                 200                 205             


Val Ala Leu Thr Val His Arg Ala Phe Arg Met Ile Gly Leu Phe Ser 
    210                 215                 220                 


His Gly Phe Leu Ala Gly Cys Ala Val Trp Asn Ile Val Val Ile Tyr 
225                 230                 235                 240 


Val Leu Ala Gly Asp Gln Leu Ser Asn Leu Ser Asn Leu Leu Gln Gln 
                245                 250                 255     


Tyr Lys Thr Leu Ala Tyr Pro Phe Gln Ser Leu Leu Tyr Leu Leu Leu 
            260                 265                 270         


Ala Leu Ser Thr Ile Ser Ala Phe Asp Arg Ile Asp Phe Ala Lys Ile 
        275                 280                 285             


Ser Val Ala Ile Arg Asn Phe Leu Ala Leu Asp Pro Thr Ala Leu Ala 
    290                 295                 300                 


Ser Phe Leu Tyr Phe Thr Ala Leu Ile Leu Ser Leu Ser Gln Gln Met 
305                 310                 315                 320 


Thr Ser Asp Arg Ile His Leu Tyr Thr Pro Ser Ser Val Asn Gly Ser 
                325                 330                 335     


Leu Trp Glu Ala Gly Ile Glu Glu Gln Ile Leu Gln Pro Trp Ile Val 
            340                 345                 350         


Val Asn Leu Val Val Ala Leu Leu Val Gly Leu Ser Trp Leu Phe Leu 
        355                 360                 365             


Ser Tyr Arg Pro Gly Met Asp Leu Ser Glu Glu Leu Met Phe Ser Ser 
    370                 375                 380                 


Glu Val Glu Glu Tyr Pro Asp Lys Glu Lys Glu Ile Lys Ala Ser Ser 
385                 390                 395                 400 


<210>  6048
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  6048

Met Met Leu Thr Gln Ala Pro Ser Ser Val Val Arg Ser Arg Asn Ser 
1               5                   10                  15      


Arg Asn His Thr Val Asn Ser Gly Gly Ser Cys Leu Ser Ala Ser Thr 
            20                  25                  30          


Val Ala Ile Pro Ala Ile Asn Asp Ser Ser Ala Ala Met Ser Ala Cys 
        35                  40                  45              


Ser Thr Ile Ser Ala Gln Pro Ala Ser Ser Met Asp Thr Gln Met His 
    50                  55                  60                  


Ser Pro Lys Lys Gln Glu Arg Val Asn Lys Arg Val Ile Trp Gly Ile 
65                  70                  75                  80  


Glu Val Ala Glu Glu Leu His Trp Lys Gly Trp Glu Leu Gly Lys Glu 
                85                  90                  95      


Thr Thr Arg Asn Leu Val Leu Lys Asn Arg Ser Leu Lys Leu Gln Lys 
            100                 105                 110         


Met Lys Tyr Arg Tyr Gln Tyr Lys Gly Ser Arg Thr Gln Cys His Ser 
        115                 120                 125             


Leu Glu Pro Arg Lys Gln Ala Leu Phe Lys Thr Lys Gln Asn Lys Gln 
    130                 135                 140                 


Lys Lys Pro Leu Thr Cys His Ile Lys Ala Ser Glu Cys Leu Lys Tyr 
145                 150                 155                 160 


Val Gln Tyr Glu 
                


<210>  6049
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  6049

Met Glu Pro Arg Ala Leu Val Thr Ala Leu Ser Leu Gly Leu Ser Leu 
1               5                   10                  15      


Cys Ser Leu Gly Leu Leu Val Thr Ala Ile Phe Thr Asp His Trp Tyr 
            20                  25                  30          


Glu Thr Asp Pro Arg Arg His Lys Glu Ser Cys Glu Arg Ser Arg Ala 
        35                  40                  45              


Gly Ala Asp Pro Pro Asp Gln Lys Asn Arg Leu Met Pro Leu Ser His 
    50                  55                  60                  


Leu Pro Leu Arg Asp Ser Pro Pro Leu Gly Arg Arg Leu Leu Pro Gly 
65                  70                  75                  80  


Gly Pro Gly Arg Ala Asp Pro Glu Ser Trp Arg Ser Leu Leu Gly Leu 
                85                  90                  95      


Gly Gly Leu Asp Ala Glu Cys Gly Arg Pro Leu Phe Ala Thr Tyr Ser 
            100                 105                 110         


Gly Leu Trp Arg Lys Cys Tyr Phe Leu Gly Ile Asp Arg Asp Ile Asp 
        115                 120                 125             


Thr Leu Ile Leu Lys Gly Ile Ala Gln Arg Cys Thr Ala Ile Lys Tyr 
    130                 135                 140                 


His Phe Ser Gln Pro Ile Arg Leu Arg Asn Ile Pro Phe Asn Leu Thr 
145                 150                 155                 160 


Lys Thr Ile Gln Gln Asp Glu Trp His Leu Leu His Leu Arg Arg Ile 
                165                 170                 175     


Thr Ala Gly Phe Leu Gly Met Ala Val Ala Val Leu Leu Cys Gly Cys 
            180                 185                 190         


Ile Val Ala Thr Val Ser Phe Phe Trp Glu Glu Ser Leu Thr Gln His 
        195                 200                 205             


Val Ala Gly Leu Leu Phe Leu Met Thr Gly Ile Phe Cys Thr Ile Ser 
    210                 215                 220                 


Leu Cys Thr Tyr Ala Ala Ser Ile Ser Tyr Asp Leu Asn Arg Leu Pro 
225                 230                 235                 240 


Lys Leu Ile Tyr Ser Leu Pro Ala Asp Val Glu His Gly Tyr Ser Trp 
                245                 250                 255     


Ser Ile Phe Cys Ala Trp Cys Ser Leu Gly Phe Ile Val Ala Ala Gly 
            260                 265                 270         


Gly Leu Cys Ile Ala Tyr Pro Phe Ile Ser Arg Thr Lys Ile Ala Gln 
        275                 280                 285             


Leu Lys Ser Gly Arg Asp Ser Thr Val 
    290                 295         


<210>  6050
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  6050

Met Glu Ala Ala Leu Leu Gly Leu Cys Asn Trp Ser Thr Leu Gly Val 
1               5                   10                  15      


Cys Ala Ala Leu Lys Leu Pro Gln Ile Ser Ala Val Leu Ala Ala Arg 
            20                  25                  30          


Ser Ala Arg Gly Leu Ser Leu Pro Ser Leu Leu Leu Glu Leu Ala Gly 
        35                  40                  45              


Phe Leu Val Phe Leu Arg Tyr Gln Cys Tyr Tyr Gly Tyr Pro Pro Leu 
    50                  55                  60                  


Thr Tyr Leu Glu Tyr Pro Ile Leu Ile Ala Gln Asp Val Ile Leu Leu 
65                  70                  75                  80  


Leu Cys Ile Phe His Phe Asn Gly Asn Val Lys Gln Ala Thr Pro Tyr 
                85                  90                  95      


Ile Ala Val Leu Val Ser Ser Trp Phe Ile Leu Ala Leu Gln Lys Trp 
            100                 105                 110         


Ile Ile Asp Leu Ala Met Asn Leu Cys Thr Phe Ile Ser Ala Ala Ser 
        115                 120                 125             


Lys Phe Ala Gln Leu Gln Cys Leu Trp Lys Thr Arg Asp Ser Gly Thr 
    130                 135                 140                 


Val Ser Ala Leu Thr Trp Ser Leu Ser Ser Tyr Thr Cys Ala Thr Arg 
145                 150                 155                 160 


Ile Ile Thr Thr Leu Met Thr Thr Asn Asp Phe Thr Ile Leu Leu Arg 
                165                 170                 175     


Phe Val Ile Met Leu Ala Leu Asn Ile Trp Val Thr Val Thr Val Leu 
            180                 185                 190         


Arg Tyr Arg Lys Thr Ala Ile Lys Ala Glu 
        195                 200         


<210>  6051
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  6051

Met Cys Ser Ala Gly Glu Leu Leu Arg Gly Gly Asp Gly Gly Glu Arg 
1               5                   10                  15      


Asp Glu Asp Gly Asp Ala Leu Ala Glu Arg Glu Ala Ala Gly Thr Glu 
            20                  25                  30          


Trp Asp Pro Gly Ala Ser Pro Arg Arg Arg Gly Gln Arg Pro Lys Glu 
        35                  40                  45              


Ser Glu Gln Asp Val Glu Asp Ser Gln Asn His Thr Gly Glu Pro Val 
    50                  55                  60                  


Gly Asp Asp Tyr Lys Lys Met Gly Thr Leu Phe Gly Glu Leu Asn Lys 
65                  70                  75                  80  


Asn Leu Ile Asn Met Gly Phe Thr Arg Met Tyr Phe Gly Glu Arg Ile 
                85                  90                  95      


Val Glu Pro Val Ile Val Ile Phe Phe Trp Val Met Leu Trp Phe Leu 
            100                 105                 110         


Gly Leu Gln Ala Leu Gly Leu Val Ala Val Leu Cys Leu Val Ile Ile 
        115                 120                 125             


Tyr Val Gln Gln 
    130         


<210>  6052
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  6052

Met Gly Leu Arg Lys Lys Ser Thr Lys Asn Pro Pro Val Leu Ser Gln 
1               5                   10                  15      


Glu Phe Ile Leu Gln Asn His Ala Asp Ile Val Ser Cys Val Gly Met 
            20                  25                  30          


Phe Phe Leu Leu Gly Leu Val Phe Glu Gly Thr Ala Glu Ala Ser Ile 
        35                  40                  45              


Val Phe Leu Thr Leu Gln His Ser Val Ala Val Pro Ala Ala Glu Glu 
    50                  55                  60                  


Gln Ala Thr Gly Ser Lys Ser Leu Tyr Tyr Tyr Gly Val Lys Asp Leu 
65                  70                  75                  80  


Ala Thr Val Phe Phe Tyr Met Leu Val Ala Ile Ile Ile His Ala Thr 
                85                  90                  95      


Ile Gln Glu Tyr Val Leu Asp Lys Ile Asn Lys Arg Met Gln Phe Thr 
            100                 105                 110         


Lys Ala Lys Gln Asn Lys Phe Asn Glu Ser Gly Gln Phe Ser Val Phe 
        115                 120                 125             


Tyr Phe Phe Ser Cys Ile Trp Gly Thr Phe Ile Leu Ile Ser Glu Asn 
    130                 135                 140                 


Cys Leu Ser Asp Pro Thr Leu Ile Trp Lys Ala Arg Pro His Ser Met 
145                 150                 155                 160 


Met Thr Phe Gln Met Lys Phe Phe Tyr Ile Ser Gln Leu Ala Tyr Trp 
                165                 170                 175     


Phe His Ala Phe Pro Glu Leu Tyr Phe Gln Lys Thr Lys Lys Gln Asp 
            180                 185                 190         


Ile Pro Arg Gln Leu Val Tyr Ile Gly Leu His Leu Phe His Ile Thr 
        195                 200                 205             


Gly Ala Tyr Leu Leu Tyr Leu Asn His Leu Gly Leu Leu Leu Leu Val 
    210                 215                 220                 


Leu His Tyr Phe Val Glu Leu Leu Ser His Met Cys Gly Leu Phe Tyr 
225                 230                 235                 240 


Phe Ser Asp Glu Lys Tyr Gln Lys Gly Ile Ser Leu Trp Ala Ile Val 
                245                 250                 255     


Phe Ile Leu Gly Arg Leu Val Thr Leu Ile Val Ser Val Leu Thr Val 
            260                 265                 270         


Gly Phe His Leu Ala Gly Ser Gln Asn Arg Asn Pro Asp Ala Leu Thr 
        275                 280                 285             


Gly Asn Val Asn Val Leu Ala Ala Lys Ile Ala Val Leu Ser Ser Ser 
    290                 295                 300                 


Cys Thr Ile Gln Ala Tyr Val Thr Trp Asn Leu Ile Thr Leu Trp Leu 
305                 310                 315                 320 


Gln Arg Trp Val Glu Asp Ser Asn Ile Gln Ala Ser Cys Met Lys Lys 
                325                 330                 335     


Lys Arg Ser Arg Ser Ser Lys Lys Arg Thr Glu Asn Gly Val Gly Val 
            340                 345                 350         


Glu Thr Ser Asn Arg Val Asp Cys Pro Pro Lys Arg Lys Glu Lys Ser 
        355                 360                 365             


Ser 
    


<210>  6053
<211>  1009
<212>  PRT
<213>  Homo sapiens

<400>  6053

Met Asp Leu Ile Arg Gly Val Leu Leu Arg Leu Leu Leu Leu Ala Ser 
1               5                   10                  15      


Ser Leu Gly Pro Gly Ala Val Ser Leu Arg Ala Ala Ile Arg Lys Pro 
            20                  25                  30          


Gly Lys Val Gly Pro Pro Leu Asp Ile Lys Leu Gly Ala Leu Asn Cys 
        35                  40                  45              


Thr Ala Phe Ser Ile Gln Trp Lys Met Pro Arg His Pro Gly Ser Pro 
    50                  55                  60                  


Ile Leu Gly Tyr Thr Val Phe Tyr Ser Glu Val Gly Ala Asp Lys Ser 
65                  70                  75                  80  


Leu Gln Glu Gln Leu His Ser Val Pro Leu Ser Arg Asp Ile Pro Thr 
                85                  90                  95      


Thr Glu Glu Val Ile Gly Asp Leu Lys Pro Gly Thr Glu Tyr Arg Val 
            100                 105                 110         


Ser Ile Ala Ala Tyr Ser Gln Ala Gly Lys Gly Arg Leu Ser Ser Pro 
        115                 120                 125             


Arg His Val Thr Thr Leu Ser Gln Asp Ser Cys Leu Pro Pro Ala Ala 
    130                 135                 140                 


Pro Gln Gln Pro His Val Ile Val Val Ser Asp Ser Glu Val Ala Leu 
145                 150                 155                 160 


Ser Trp Lys Pro Gly Ala Ser Glu Gly Ser Ala Pro Ile Gln Tyr Tyr 
                165                 170                 175     


Ser Val Glu Phe Ile Arg Pro Asp Phe Asp Lys Lys Trp Thr Ser Ile 
            180                 185                 190         


His Glu Arg Ile Gln Met Asp Ser Met Val Ile Lys Gly Leu Asp Pro 
        195                 200                 205             


Asp Thr Asn Tyr Gln Phe Ala Val Arg Ala Met Asn Ser His Gly Pro 
    210                 215                 220                 


Ser Pro Arg Ser Trp Pro Ser Asp Ile Ile Arg Thr Leu Cys Pro Glu 
225                 230                 235                 240 


Glu Ala Gly Ser Gly Arg Tyr Gly Pro Arg Tyr Ile Thr Asp Met Gly 
                245                 250                 255     


Ala Gly Glu Asp Asp Glu Gly Phe Glu Asp Asp Leu Asp Leu Asp Ile 
            260                 265                 270         


Ser Phe Glu Glu Val Lys Pro Leu Pro Ala Thr Lys Gly Gly Asn Lys 
        275                 280                 285             


Lys Phe Leu Val Glu Ser Lys Lys Met Ser Ile Ser Asn Pro Lys Thr 
    290                 295                 300                 


Ile Ser Arg Leu Ile Pro Pro Thr Ser Ala Ser Leu Pro Val Thr Thr 
305                 310                 315                 320 


Val Ala Pro Gln Pro Ile Pro Ile Gln Arg Lys Gly Lys Asn Gly Val 
                325                 330                 335     


Ala Ile Met Ser Arg Leu Phe Asp Met Pro Cys Asp Glu Thr Leu Cys 
            340                 345                 350         


Ser Ala Asp Ser Phe Cys Val Asn Asp Tyr Thr Trp Gly Gly Ser Arg 
        355                 360                 365             


Cys Gln Cys Thr Leu Gly Lys Gly Gly Glu Ser Cys Ser Glu Asp Ile 
    370                 375                 380                 


Val Ile Gln Tyr Pro Gln Phe Phe Gly His Ser Tyr Val Thr Phe Glu 
385                 390                 395                 400 


Pro Leu Lys Asn Ser Tyr Gln Ala Phe Gln Ile Thr Leu Glu Phe Arg 
                405                 410                 415     


Ala Glu Ala Glu Asp Gly Leu Leu Leu Tyr Cys Gly Glu Asn Glu His 
            420                 425                 430         


Gly Arg Gly Asp Phe Met Ser Leu Ala Ile Ile Arg Arg Ser Leu Gln 
        435                 440                 445             


Phe Arg Phe Asn Cys Gly Thr Gly Val Ala Ile Ile Val Ser Glu Thr 
    450                 455                 460                 


Lys Ile Lys Leu Gly Gly Trp His Thr Val Met Leu Tyr Arg Asp Gly 
465                 470                 475                 480 


Leu Asn Gly Leu Leu Gln Leu Asn Asn Gly Thr Pro Val Thr Gly Gln 
                485                 490                 495     


Ser Gln Gly Gln Tyr Ser Lys Ile Thr Phe Arg Thr Pro Leu Tyr Leu 
            500                 505                 510         


Gly Gly Ala Pro Ser Ala Tyr Trp Leu Val Arg Ala Thr Gly Thr Asn 
        515                 520                 525             


Arg Gly Phe Gln Gly Cys Val Gln Ser Leu Ala Val Asn Gly Arg Arg 
    530                 535                 540                 


Ile Asp Met Arg Pro Trp Pro Leu Gly Lys Ala Leu Ser Gly Ala Asp 
545                 550                 555                 560 


Val Gly Glu Cys Ser Ser Gly Ile Cys Asp Glu Ala Ser Cys Ile His 
                565                 570                 575     


Gly Gly Thr Cys Thr Ala Ile Lys Ala Asp Ser Tyr Ile Cys Leu Cys 
            580                 585                 590         


Pro Leu Gly Phe Lys Gly Arg His Cys Glu Asp Ala Phe Thr Leu Thr 
        595                 600                 605             


Ile Pro Gln Phe Arg Glu Ser Leu Arg Ser Tyr Ala Ala Thr Pro Trp 
    610                 615                 620                 


Pro Leu Glu Pro Gln His Tyr Leu Ser Phe Met Glu Phe Glu Ile Thr 
625                 630                 635                 640 


Phe Arg Pro Asp Ser Gly Asp Gly Val Leu Leu Tyr Ser Tyr Asp Thr 
                645                 650                 655     


Gly Ser Lys Asp Phe Leu Ser Ile Asn Leu Ala Gly Gly His Val Glu 
            660                 665                 670         


Phe Arg Phe Asp Cys Gly Ser Gly Thr Gly Val Leu Arg Ser Glu Asp 
        675                 680                 685             


Pro Leu Thr Leu Gly Asn Trp His Glu Leu Arg Val Ser Arg Thr Ala 
    690                 695                 700                 


Lys Asn Gly Ile Leu Gln Val Asp Lys Gln Lys Ile Val Glu Gly Met 
705                 710                 715                 720 


Ala Glu Gly Gly Phe Thr Gln Ile Lys Cys Asn Thr Asp Ile Phe Ile 
                725                 730                 735     


Gly Gly Val Pro Asn Tyr Asp Asp Val Lys Lys Asn Ser Gly Val Leu 
            740                 745                 750         


Lys Pro Phe Ser Gly Ser Ile Gln Lys Ile Ile Leu Asn Asp Arg Thr 
        755                 760                 765             


Ile His Val Lys His Asp Phe Thr Ser Gly Val Asn Val Glu Asn Ala 
    770                 775                 780                 


Ala His Pro Cys Val Arg Ala Pro Cys Ala His Gly Gly Ser Cys Arg 
785                 790                 795                 800 


Pro Arg Lys Glu Gly Tyr Asp Cys Asp Cys Pro Leu Gly Phe Glu Gly 
                805                 810                 815     


Leu His Cys Gln Lys Ala Ile Ile Glu Ala Ile Glu Ile Pro Gln Phe 
            820                 825                 830         


Ile Gly Arg Ser Tyr Leu Thr Tyr Asp Asn Pro Asp Ile Leu Lys Arg 
        835                 840                 845             


Val Ser Gly Ser Arg Ser Asn Val Phe Met Arg Phe Lys Thr Thr Ala 
    850                 855                 860                 


Lys Asp Gly Leu Leu Leu Trp Arg Gly Asp Ser Pro Met Arg Pro Asn 
865                 870                 875                 880 


Ser Asp Phe Ile Ser Leu Gly Leu Arg Asp Gly Ala Leu Val Phe Ser 
                885                 890                 895     


Tyr Asn Leu Gly Ser Gly Val Ala Ser Ile Met Val Asn Gly Ser Phe 
            900                 905                 910         


Asn Asp Gly Arg Trp His Arg Val Lys Ala Val Arg Asp Gly Gln Ser 
        915                 920                 925             


Gly Lys Ile Thr Val Asp Asp Tyr Gly Ala Arg Thr Gly Lys Ser Pro 
    930                 935                 940                 


Gly Met Met Arg Gln Leu Asn Ile Asn Gly Ala Leu Tyr Val Gly Gly 
945                 950                 955                 960 


Met Lys Glu Ile Ala Leu His Thr Asn Arg Gln Tyr Met Arg Gly Leu 
                965                 970                 975     


Val Gly Cys Ile Ser His Phe Thr Leu Ser Thr Asp Tyr His Ile Ser 
            980                 985                 990         


Leu Val Glu Asp Ala Val Asp Gly  Lys Asn Ile Asn Thr  Cys Gly Ala 
        995                 1000                 1005             


Lys 
    


<210>  6054
<211>  523
<212>  PRT
<213>  Homo sapiens

<400>  6054

Met Val Gly Gln Arg Val Leu Leu Leu Val Ala Phe Leu Leu Ser Gly 
1               5                   10                  15      


Val Leu Leu Ser Glu Ala Ala Lys Ile Leu Thr Ile Ser Thr Leu Gly 
            20                  25                  30          


Gly Ser His Tyr Leu Leu Leu Asp Arg Val Ser Gln Ile Leu Gln Glu 
        35                  40                  45              


His Gly His Asn Val Thr Met Leu His Gln Ser Gly Lys Phe Leu Ile 
    50                  55                  60                  


Pro Asp Ile Lys Glu Glu Glu Lys Ser Tyr Gln Val Ile Arg Trp Phe 
65                  70                  75                  80  


Ser Pro Glu Asp His Gln Lys Arg Ile Lys Lys His Phe Asp Ser Tyr 
                85                  90                  95      


Ile Glu Thr Ala Leu Asp Gly Arg Lys Glu Ser Glu Ala Leu Val Lys 
            100                 105                 110         


Leu Met Glu Ile Phe Gly Thr Gln Cys Ser Tyr Leu Leu Ser Arg Lys 
        115                 120                 125             


Asp Ile Met Asp Ser Leu Lys Asn Glu Asn Tyr Asp Leu Val Phe Val 
    130                 135                 140                 


Glu Ala Phe Asp Phe Cys Ser Phe Leu Ile Ala Glu Lys Leu Val Lys 
145                 150                 155                 160 


Pro Phe Val Ala Ile Leu Pro Thr Thr Phe Gly Ser Leu Asp Phe Gly 
                165                 170                 175     


Leu Pro Ser Pro Leu Ser Tyr Val Pro Val Phe Pro Ser Leu Leu Thr 
            180                 185                 190         


Asp His Met Asp Phe Trp Gly Arg Val Lys Asn Phe Leu Met Phe Phe 
        195                 200                 205             


Ser Phe Ser Arg Ser Gln Trp Asp Met Gln Ser Thr Phe Asp Asn Thr 
    210                 215                 220                 


Ile Lys Glu His Phe Pro Glu Gly Ser Arg Pro Val Leu Ser His Leu 
225                 230                 235                 240 


Leu Leu Lys Ala Glu Leu Trp Phe Val Asn Ser Asp Phe Ala Phe Asp 
                245                 250                 255     


Phe Ala Arg Pro Leu Leu Pro Asn Thr Val Tyr Ile Gly Gly Leu Met 
            260                 265                 270         


Glu Lys Pro Ile Lys Pro Val Pro Gln Asp Leu Asp Asn Phe Ile Ala 
        275                 280                 285             


Asn Phe Gly Asp Ala Gly Phe Val Leu Val Ala Phe Gly Ser Met Leu 
    290                 295                 300                 


Asn Thr His Gln Ser Gln Glu Val Leu Lys Lys Met His Asn Ala Phe 
305                 310                 315                 320 


Ala His Leu Pro Gln Gly Val Ile Trp Thr Cys Gln Ser Ser His Trp 
                325                 330                 335     


Pro Arg Asp Val His Leu Ala Thr Asn Val Lys Ile Val Asp Trp Leu 
            340                 345                 350         


Pro Gln Ser Asp Leu Leu Ala His Pro Ser Ile Arg Leu Phe Val Thr 
        355                 360                 365             


His Gly Gly Gln Asn Ser Val Met Glu Ala Ile Arg His Gly Val Pro 
    370                 375                 380                 


Met Val Gly Leu Pro Val Asn Gly Asp Gln His Gly Asn Met Val Arg 
385                 390                 395                 400 


Val Val Ala Lys Asn Tyr Gly Val Ser Ile Arg Leu Asn Gln Val Thr 
                405                 410                 415     


Ala Asp Thr Leu Thr Leu Thr Met Lys Gln Val Ile Glu Asp Lys Arg 
            420                 425                 430         


Tyr Lys Ser Ala Val Val Ala Ala Ser Val Ile Leu His Ser Gln Pro 
        435                 440                 445             


Leu Ser Pro Ala Gln Arg Leu Val Gly Trp Ile Asp His Ile Leu Gln 
    450                 455                 460                 


Thr Gly Gly Ala Thr His Leu Lys Pro Tyr Ala Phe Gln Gln Pro Trp 
465                 470                 475                 480 


His Glu Gln Tyr Leu Ile Asp Val Phe Val Phe Leu Leu Gly Leu Thr 
                485                 490                 495     


Leu Gly Thr Met Trp Leu Cys Gly Lys Leu Leu Gly Val Val Ala Arg 
            500                 505                 510         


Trp Leu Arg Gly Ala Arg Lys Val Lys Lys Thr 
        515                 520             


<210>  6055
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  6055

Met Val Ala Glu Lys Glu Thr Leu Ser Leu Asn Lys Cys Pro Asp Lys 
1               5                   10                  15      


Met Pro Lys Arg Thr Lys Leu Leu Ala Gln Gln Pro Leu Pro Val His 
            20                  25                  30          


Gln Pro His Ser Leu Val Ser Glu Gly Phe Thr Val Lys Ala Met Met 
        35                  40                  45              


Lys Asn Ser Val Val Arg Gly Pro Pro Ala Ala Gly Ala Phe Lys Glu 
    50                  55                  60                  


Arg Pro Thr Lys Pro Thr Ala Phe Arg Lys Phe Tyr Glu Arg Gly Asp 
65                  70                  75                  80  


Phe Pro Ile Ala Leu Glu His Asp Ser Lys Gly Asn Lys Ile Ala Trp 
                85                  90                  95      


Lys Val Glu Ile Glu Lys Leu Asp Tyr His His Tyr Leu Pro Leu Phe 
            100                 105                 110         


Phe Asp Gly Leu Cys Glu Met Thr Phe Pro Tyr Glu Phe Phe Ala Arg 
        115                 120                 125             


Gln Gly Ile His Asp Met Leu Glu His Gly Gly Asn Lys Ile Leu Pro 
    130                 135                 140                 


Val Leu Pro Gln Leu Ile Ile Pro Ile Lys Asn Ala Leu Asn Leu Arg 
145                 150                 155                 160 


Asn Arg Gln Val Ile Cys Val Thr Leu Lys Val Leu Gln His Leu Val 
                165                 170                 175     


Val Ser Ala Glu Met Val Gly Lys Ala Leu Val Pro Tyr Tyr Arg Gln 
            180                 185                 190         


Ile Leu Pro Val Leu Asn Ile Phe Lys Asn Met Asn Gly Ser Tyr Ser 
        195                 200                 205             


Leu Pro Arg Leu Glu Cys Ser Gly Ala Ile Met Ala Arg Cys Asn Leu 
    210                 215                 220                 


Asp His Leu Gly Ser Ser Asp Pro Pro Thr Ser Ala Ser Gln Val Ala 
225                 230                 235                 240 


Glu Ile Ile Val Asn Ser Gly Asp Gly Ile Asp Tyr Ser Gln Gln Lys 
                245                 250                 255     


Arg Glu Asn Ile Gly Asp Leu Ile Gln Glu Thr Leu Glu Ala Phe Glu 
            260                 265                 270         


Arg Tyr Gly Gly Glu Asn Ala Phe Ile Asn Ile Lys Tyr Val Val Pro 
        275                 280                 285             


Thr Tyr Glu Ser Cys Leu Leu Asn 
    290                 295     


<210>  6056
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  6056

Met Ile Asp Lys Asn Gln Thr Cys Gly Val Gly Gln Asp Ser Val Pro 
1               5                   10                  15      


Tyr Met Ile Cys Leu Ile His Ile Leu Glu Glu Trp Phe Gly Val Glu 
            20                  25                  30          


Gln Leu Glu Asp Tyr Leu Asn Phe Ala Asn Tyr Leu Leu Trp Val Phe 
        35                  40                  45              


Thr Pro Leu Ile Leu Leu Ile Leu Pro Tyr Phe Thr Ile Phe Leu Leu 
    50                  55                  60                  


Tyr Leu Thr Ile Ile Phe Leu His Ile Tyr Lys Arg Lys Asn Val Leu 
65                  70                  75                  80  


Lys Glu Ala Tyr Ser His Asn Leu Trp Asp Gly Ala Arg Lys Thr Val 
                85                  90                  95      


Ala Thr Leu Trp Asp Gly His Ala Ala Val Trp His Gly Tyr Glu Val 
            100                 105                 110         


His Gly Met Glu Lys Ile Pro Glu Asp Gly Pro Ala Leu Ile Ile Phe 
        115                 120                 125             


Tyr His Gly Ala Ile Pro Ile Asp Phe Tyr Tyr Phe Met Ala Lys Ile 
    130                 135                 140                 


Phe Ile His Lys Gly Arg Thr Cys Arg Val Val Ala Asp His Phe Val 
145                 150                 155                 160 


Phe Lys Ile Pro Gly Phe Ser Leu Leu Leu Asp Val Phe Cys Ala Leu 
                165                 170                 175     


His Gly Pro Arg Glu Lys Cys Val Glu Ile Leu Arg Ser Gly His Leu 
            180                 185                 190         


Leu Ala Ile Ser Pro Gly Gly Val Arg Glu Ala Leu Ile Ser Asp Glu 
        195                 200                 205             


Thr Tyr Asn Ile Val Trp Gly His Arg Arg Gly Phe Ala Gln Val Ala 
    210                 215                 220                 


Ile Asp Ala Lys Val Thr Lys Asn Ala Val Gln Ala Leu Ile Asp Lys 
225                 230                 235                 240 


His Gln Arg Ile Pro Gly Asn Ile Met Ser Ala Leu Leu Glu Arg Phe 
                245                 250                 255     


His 
    


<210>  6057
<211>  635
<212>  PRT
<213>  Homo sapiens

<400>  6057

Met Ser Gly Ala Gly Arg Ala Leu Ala Ala Leu Leu Leu Ala Ala Ser 
1               5                   10                  15      


Val Leu Ser Ala Ala Leu Leu Ala Pro Gly Gly Ser Ser Gly Arg Asp 
            20                  25                  30          


Ala Gln Ala Ala Pro Pro Arg Asp Leu Asp Lys Lys Arg His Ala Glu 
        35                  40                  45              


Leu Lys Met Asp Gln Ala Leu Leu Leu Ile His Asn Glu Leu Leu Trp 
    50                  55                  60                  


Thr Asn Leu Thr Val Tyr Trp Lys Ser Glu Cys Cys Tyr His Cys Leu 
65                  70                  75                  80  


Phe Gln Val Leu Val Asn Val Pro Gln Ser Pro Lys Ala Gly Lys Pro 
                85                  90                  95      


Ser Ala Ala Ala Ala Ser Val Ser Thr Gln His Gly Ser Ile Leu Gln 
            100                 105                 110         


Leu Asn Asp Thr Leu Glu Glu Lys Glu Val Cys Arg Leu Glu Tyr Arg 
        115                 120                 125             


Phe Gly Glu Phe Gly Asn Tyr Ser Leu Leu Val Lys Asn Ile His Asn 
    130                 135                 140                 


Gly Val Ser Glu Ile Ala Cys Asp Leu Ala Val Asn Glu Asp Pro Val 
145                 150                 155                 160 


Asp Ser Asn Leu Pro Val Ser Ile Ala Phe Leu Ile Gly Leu Ala Val 
                165                 170                 175     


Ile Ile Val Ile Ser Phe Leu Arg Leu Leu Leu Ser Leu Asp Asp Phe 
            180                 185                 190         


Asn Asn Trp Ile Ser Lys Ala Ile Ser Ser Arg Glu Thr Asp Arg Leu 
        195                 200                 205             


Ile Asn Ser Glu Leu Gly Ser Pro Ser Arg Thr Asp Pro Leu Asp Gly 
    210                 215                 220                 


Asp Val Gln Pro Ala Thr Trp Arg Leu Ser Ala Leu Pro Pro Arg Leu 
225                 230                 235                 240 


Arg Ser Val Asp Thr Phe Arg Gly Ile Ala Leu Ile Leu Met Val Phe 
                245                 250                 255     


Val Asn Tyr Gly Gly Gly Lys Tyr Trp Tyr Phe Lys His Ala Ser Trp 
            260                 265                 270         


Asn Gly Leu Thr Val Ala Asp Leu Val Phe Pro Trp Phe Val Phe Ile 
        275                 280                 285             


Met Gly Ser Ser Ile Phe Leu Ser Met Thr Ser Ile Leu Gln Arg Gly 
    290                 295                 300                 


Cys Ser Lys Phe Arg Leu Leu Gly Lys Ile Ala Trp Arg Ser Phe Leu 
305                 310                 315                 320 


Leu Ile Cys Ile Gly Ile Ile Ile Val Asn Pro Asn Tyr Cys Leu Gly 
                325                 330                 335     


Pro Leu Ser Trp Asp Lys Val Arg Ile Pro Gly Val Leu Gln Arg Leu 
            340                 345                 350         


Gly Val Thr Tyr Phe Val Val Ala Val Leu Glu Leu Leu Phe Ala Lys 
        355                 360                 365             


Pro Val Pro Glu His Cys Ala Ser Glu Arg Ser Cys Leu Ser Leu Arg 
    370                 375                 380                 


Asp Ile Thr Ser Ser Trp Pro Gln Trp Leu Leu Ile Leu Val Leu Glu 
385                 390                 395                 400 


Gly Leu Trp Leu Gly Leu Thr Phe Leu Leu Pro Val Pro Gly Cys Pro 
                405                 410                 415     


Thr Gly Tyr Leu Gly Pro Gly Gly Ile Gly Asp Phe Gly Lys Tyr Pro 
            420                 425                 430         


Asn Cys Thr Gly Gly Ala Ala Gly Tyr Ile Asp Arg Leu Leu Leu Gly 
        435                 440                 445             


Asp Asp His Leu Tyr Gln His Pro Ser Ser Ala Val Leu Tyr His Thr 
    450                 455                 460                 


Glu Val Ala Tyr Asp Pro Glu Gly Ile Leu Gly Thr Ile Asn Ser Ile 
465                 470                 475                 480 


Val Met Ala Phe Leu Gly Val Gln Ala Gly Lys Ile Leu Leu Tyr Tyr 
                485                 490                 495     


Lys Ala Arg Thr Lys Asp Ile Leu Ile Arg Phe Thr Ala Trp Cys Cys 
            500                 505                 510         


Ile Leu Gly Leu Ile Ser Val Ala Leu Thr Lys Val Ser Glu Asn Glu 
        515                 520                 525             


Gly Phe Ile Pro Val Asn Lys Asn Leu Trp Ser Leu Ser Tyr Val Thr 
    530                 535                 540                 


Thr Leu Ser Ser Phe Ala Phe Phe Ile Leu Leu Val Leu Tyr Pro Val 
545                 550                 555                 560 


Val Asp Val Lys Gly Leu Trp Thr Gly Thr Pro Phe Phe Tyr Pro Gly 
                565                 570                 575     


Met Asn Ser Ile Leu Val Tyr Val Gly His Glu Val Phe Glu Asn Tyr 
            580                 585                 590         


Phe Pro Phe Gln Trp Lys Leu Lys Asp Asn Gln Ser His Lys Glu His 
        595                 600                 605             


Leu Thr Gln Asn Ile Val Ala Thr Ala Leu Trp Val Leu Ile Ala Tyr 
    610                 615                 620                 


Ile Leu Tyr Arg Lys Lys Ile Phe Trp Lys Ile 
625                 630                 635 


<210>  6058
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  6058

Met Arg Arg Leu Arg Arg Leu Ala His Leu Val Leu Phe Cys Pro Phe 
1               5                   10                  15      


Ser Lys Arg Leu Gln Gly Arg Leu Pro Gly Leu Arg Val Arg Cys Ile 
            20                  25                  30          


Phe Leu Ala Trp Leu Gly Val Phe Ala Gly Ser Trp Leu Val Tyr Val 
        35                  40                  45              


His Tyr Ser Ser Tyr Ser Glu Arg Cys Arg Gly His Val Cys Gln Val 
    50                  55                  60                  


Val Ile Cys Asp Gln Tyr Arg Lys Gly Ile Ile Ser Gly Ser Val Cys 
65                  70                  75                  80  


Gln Asp Leu Cys Glu Leu His Met Val Glu Trp Arg Thr Cys Leu Ser 
                85                  90                  95      


Val Ala Pro Gly Gln Gln Val Tyr Ser Gly Leu Trp Arg Asp Lys Asp 
            100                 105                 110         


Val Thr Ile Lys Cys Gly Ile Glu Glu Thr Leu Asp Ser Lys Ala Arg 
        115                 120                 125             


Ser Asp Ala Ala Pro Arg Arg Glu Leu Val Leu Phe Asp Lys Pro Thr 
    130                 135                 140                 


Arg Gly Thr Ser Ile Lys Glu Phe Arg Glu Met Thr Leu Ser Phe Leu 
145                 150                 155                 160 


Lys Ala Asn Leu Gly Asp Leu Pro Ser Leu Pro Ala Leu Val Gly Gln 
                165                 170                 175     


Val Leu Leu Met Ala Asp Phe Asn Lys Asp Asn Arg Val Ser Leu Ala 
            180                 185                 190         


Glu Ala Lys Ser Val Trp Ala Leu Leu Gln Arg Asn Glu Phe Leu Leu 
        195                 200                 205             


Leu Leu Ser Leu Gln Glu Lys Glu His Ala Ser Arg Leu Leu Gly Tyr 
    210                 215                 220                 


Cys Gly Asp Leu Tyr Leu Thr Glu Gly Val Pro His Gly Ala Trp His 
225                 230                 235                 240 


Ala Ala Ala Leu Pro Pro Leu Leu Arg Pro Leu Leu Pro Pro Ala Leu 
                245                 250                 255     


Gln Gly Ala Leu Gln Gln Trp Leu Gly Pro Ala Trp Pro Trp Arg Ala 
            260                 265                 270         


Lys Ile Ala Ile Gly Leu Leu Glu Phe Val Glu Glu Leu Phe His Gly 
        275                 280                 285             


Ser Tyr Gly Thr Phe Tyr Met Cys Glu Thr Thr Leu Ala Asn Val Gly 
    290                 295                 300                 


Tyr Thr Ala Thr Tyr Asp Phe Lys Met Ala Asp Leu Gln Gln Val Ala 
305                 310                 315                 320 


Pro Glu Ala Thr Val Arg Arg Phe Leu Gln Gly Arg Arg Cys Glu His 
                325                 330                 335     


Ser Thr Asp Cys Thr Tyr Gly Arg Asp Cys Arg Ala Pro Cys Asp Arg 
            340                 345                 350         


Leu Met Arg Gln Cys Lys Gly Asp Leu Ile Gln Pro Asn Leu Ala Lys 
        355                 360                 365             


Val Cys Ala Leu Leu Arg Gly Tyr Leu Leu Pro Gly Ala Pro Ala Asp 
    370                 375                 380                 


Leu Arg Glu Glu Leu Gly Thr Gln Leu Arg Thr Cys Thr Thr Leu Ser 
385                 390                 395                 400 


Gly Leu Ala Ser Gln Val Glu Ala His His Ser Leu Val Leu Ser His 
                405                 410                 415     


Leu Lys Thr Leu Leu Trp Lys Lys Ile Ser Asn Thr Lys Tyr Ser 
            420                 425                 430     


<210>  6059
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  6059

Met Thr Thr Asp Glu Arg Lys Leu Phe Asn His Leu Lys Ser Pro His 
1               5                   10                  15      


Leu Lys Tyr Trp Val Pro Phe Ile Trp Phe Gly Asn Leu Ala Thr Lys 
            20                  25                  30          


Ala Arg Asn Glu Gly Arg Ile Arg Asp Ser Val Asp Leu Gln Ser Leu 
        35                  40                  45              


Met Thr Glu Met Asn Arg Tyr Arg Ser Trp Cys Ser Leu Leu Phe Gly 
    50                  55                  60                  


Tyr Asp Trp Val Gly Ile Pro Leu Val Tyr Thr Gln Val Ala Glu Gln 
65                  70                  75                  80  


Leu Ile Asn Pro Phe Gly Glu Asp Asp Asp Asp Phe Glu Thr Asn Trp 
                85                  90                  95      


Cys Ile Asp Arg Asn Leu Gln Val Ser Leu Leu Ala Val Asp Glu Met 
            100                 105                 110         


His Met Ser Leu Pro Lys Met Lys Lys Asp Ile Tyr Trp Asp Asp Ser 
        115                 120                 125             


Ala Ala Arg Pro Pro Tyr Thr Leu Ala Ala Ala Asp Tyr Cys Ile Pro 
    130                 135                 140                 


Ser Phe Leu Gly Ser Thr Val Gln Met Gly Leu Ser Gly Ser Asp Phe 
145                 150                 155                 160 


Pro Asp Glu Glu Trp Leu Trp Asp Tyr Glu Lys His Gly His Arg His 
                165                 170                 175     


Ser Met Ile Arg Arg Val Lys Arg Phe Leu Ser Ala His Glu His Pro 
            180                 185                 190         


Ser Ser Pro Arg Arg Arg Ser Tyr Arg Arg Gln Thr Ser Asp Ser Ser 
        195                 200                 205             


Met Phe Leu Pro Arg Asp Asp Leu Ser Pro Ala Arg Asp Leu Leu Asp 
    210                 215                 220                 


Val Pro Ser Arg Asn Pro Pro Arg Ala Ser Pro Thr Trp Lys Lys Ser 
225                 230                 235                 240 


Cys Phe Pro Glu Gly Ser Pro Thr Leu His Phe Ser Met Gly Glu Leu 
                245                 250                 255     


Ser Thr Ile Arg Glu Thr Ser Gln Thr Ser Thr Leu Gln Ser Leu Thr 
            260                 265                 270         


Pro Gln Ser Ser Val Arg Thr Ser Pro Ile Lys Met Pro Leu Val Pro 
        275                 280                 285             


Glu Val Leu Ile Thr Ala Ala Glu Ala Pro Val Pro Thr Ser Gly Gly 
    290                 295                 300                 


Tyr His His Asp Ser Ala Thr Ser Ile Leu Ser Ser Glu Phe Thr Gly 
305                 310                 315                 320 


Val Gln Pro Ser Lys Thr Glu Gln Gln Gln Gly Pro Met Gly Ser Ile 
                325                 330                 335     


Leu Ser Pro Ser Glu Lys Glu Thr Pro Pro Gly Gly Pro Ser Pro Gln 
            340                 345                 350         


Thr Val Ser Ala Ser Ala Glu Glu Asn Ile Phe Asn Cys Glu Glu Asp 
        355                 360                 365             


Pro Gly Asp Thr Phe Leu Lys Arg Trp Ser Leu Pro Gly Phe Leu Gly 
    370                 375                 380                 


Ser Ser His Thr Ser Leu Gly Asn Leu Ser Pro Asp Pro Met Ser Ser 
385                 390                 395                 400 


Gln Pro Ala Leu Leu Ile Asp Thr Glu Thr Ser Ser Glu Ile Ser Gly 
                405                 410                 415     


Ile Asn Ile Val Ala Gly Ser Arg Val Ser Ser Asp Met Leu Tyr Leu 
            420                 425                 430         


Met Glu Asn Leu Asp Thr Lys Glu Thr Asp Ile Ile Glu Leu Asn Lys 
        435                 440                 445             


Glu Thr Glu Glu Ser Pro Lys 
    450                 455 


<210>  6060
<211>  719
<212>  PRT
<213>  Homo sapiens

<400>  6060

Met Glu Lys Ile Leu Phe Tyr Leu Phe Leu Ile Gly Ile Ala Val Lys 
1               5                   10                  15      


Ala Gln Ile Cys Pro Lys Arg Cys Val Cys Gln Ile Leu Ser Pro Asn 
            20                  25                  30          


Leu Ala Thr Leu Cys Ala Lys Lys Gly Leu Leu Phe Val Pro Pro Asn 
        35                  40                  45              


Ile Asp Arg Arg Thr Val Glu Leu Arg Leu Ala Asp Asn Phe Val Thr 
    50                  55                  60                  


Asn Ile Lys Arg Lys Asp Phe Ala Asn Met Thr Ser Leu Val Asp Leu 
65                  70                  75                  80  


Thr Leu Ser Arg Asn Thr Ile Ser Phe Ile Thr Pro His Ala Phe Ala 
                85                  90                  95      


Asp Leu Arg Asn Leu Arg Ala Leu His Leu Asn Ser Asn Arg Leu Thr 
            100                 105                 110         


Lys Ile Thr Asn Asp Met Phe Ser Gly Leu Ser Asn Leu His His Leu 
        115                 120                 125             


Ile Leu Asn Asn Asn Gln Leu Thr Leu Ile Ser Ser Thr Ala Phe Asp 
    130                 135                 140                 


Asp Val Phe Ala Leu Glu Glu Leu Asp Leu Ser Tyr Asn Asn Leu Glu 
145                 150                 155                 160 


Thr Ile Pro Trp Asp Ala Val Glu Lys Met Val Ser Leu His Thr Leu 
                165                 170                 175     


Ser Leu Asp His Asn Met Ile Asp Asn Ile Pro Lys Gly Thr Phe Ser 
            180                 185                 190         


His Leu His Lys Met Thr Arg Leu Asp Val Thr Ser Asn Lys Leu Gln 
        195                 200                 205             


Lys Leu Pro Pro Asp Pro Leu Phe Gln Arg Ala Gln Val Leu Ala Thr 
    210                 215                 220                 


Ser Gly Ile Ile Ser Pro Ser Thr Phe Ala Leu Ser Phe Gly Gly Asn 
225                 230                 235                 240 


Pro Leu His Cys Asn Cys Glu Leu Leu Trp Leu Arg Arg Leu Ser Arg 
                245                 250                 255     


Glu Asp Asp Leu Glu Thr Cys Ala Ser Pro Pro Leu Leu Thr Gly Arg 
            260                 265                 270         


Tyr Phe Trp Ser Ile Pro Glu Glu Glu Phe Leu Cys Glu Pro Pro Leu 
        275                 280                 285             


Ile Thr Arg His Thr His Glu Met Arg Val Leu Glu Gly Gln Arg Ala 
    290                 295                 300                 


Thr Leu Arg Cys Lys Ala Arg Gly Asp Pro Glu Pro Ala Ile His Trp 
305                 310                 315                 320 


Ile Ser Pro Glu Gly Lys Leu Ile Ser Asn Ala Thr Arg Ser Leu Val 
                325                 330                 335     


Tyr Asp Asn Gly Thr Leu Asp Ile Leu Ile Thr Thr Val Lys Asp Thr 
            340                 345                 350         


Gly Ala Phe Thr Cys Ile Ala Ser Asn Pro Ala Gly Glu Ala Thr Gln 
        355                 360                 365             


Ile Val Asp Leu His Ile Ile Lys Leu Pro His Leu Leu Asn Ser Thr 
    370                 375                 380                 


Asn His Ile His Glu Pro Asp Pro Gly Ser Ser Asp Ile Ser Thr Ser 
385                 390                 395                 400 


Thr Lys Ser Gly Ser Asn Thr Ser Ser Ser Asn Gly Asp Thr Lys Leu 
                405                 410                 415     


Ser Gln Asp Lys Ile Val Val Ala Glu Ala Thr Ser Ser Thr Ala Leu 
            420                 425                 430         


Leu Lys Phe Asn Phe Gln Arg Asn Ile Pro Gly Ile Arg Met Phe Gln 
        435                 440                 445             


Ile Gln Tyr Asn Gly Thr Tyr Asp Asp Thr Leu Val Tyr Arg Met Ile 
    450                 455                 460                 


Pro Pro Thr Ser Lys Thr Phe Leu Val Asn Asn Leu Ala Ala Gly Thr 
465                 470                 475                 480 


Met Tyr Asp Leu Cys Val Leu Ala Ile Tyr Asp Asp Gly Ile Thr Ser 
                485                 490                 495     


Leu Thr Ala Thr Arg Val Val Gly Cys Ile Gln Phe Thr Thr Glu Gln 
            500                 505                 510         


Asp Tyr Val Arg Cys His Phe Met Gln Ser Gln Phe Leu Gly Gly Thr 
        515                 520                 525             


Met Ile Ile Ile Ile Gly Gly Ile Ile Val Ala Ser Val Leu Val Phe 
    530                 535                 540                 


Ile Ile Ile Leu Met Ile Arg Tyr Lys Val Cys Asn Asn Asn Gly Gln 
545                 550                 555                 560 


His Lys Val Thr Lys Val Ser Asn Val Tyr Ser Gln Thr Asn Gly Ala 
                565                 570                 575     


Gln Ile Gln Gly Cys Ser Val Thr Leu Pro Gln Ser Val Ser Lys Gln 
            580                 585                 590         


Ala Val Gly His Glu Glu Asn Ala Gln Cys Cys Lys Ala Thr Ser Asp 
        595                 600                 605             


Asn Val Ile Gln Ser Ser Glu Thr Cys Ser Ser Gln Asp Ser Ser Thr 
    610                 615                 620                 


Thr Thr Ser Ala Leu Pro Pro Ser Trp Thr Ser Ser Thr Ser Val Ser 
625                 630                 635                 640 


Gln Lys Gln Lys Arg Lys Thr Gly Thr Lys Pro Ser Thr Glu Pro Gln 
                645                 650                 655     


Asn Glu Ala Val Thr Asn Val Glu Ser Gln Asn Thr Asn Arg Asn Asn 
            660                 665                 670         


Ser Thr Ala Leu Gln Leu Ala Ser Arg Pro Pro Asp Ser Val Thr Glu 
        675                 680                 685             


Gly Pro Thr Ser Lys Arg Ala His Ile Lys Pro Asn Ala Leu Leu Thr 
    690                 695                 700                 


Asn Val Asp Gln Ile Val Gln Glu Thr Gln Arg Leu Glu Leu Ile 
705                 710                 715                 


<210>  6061
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  6061

Met Ala Val Gly Thr Arg Gly Thr Leu Leu Lys Lys Ser Leu Thr Val 
1               5                   10                  15      


Trp Phe Cys Gly Pro Gly Ala Arg Ser Ala Thr Arg Ala Val Ser Thr 
            20                  25                  30          


Ser Leu Pro Arg Arg Glu Gln Val Thr Trp Cys Cys Cys Ser Gly Ser 
        35                  40                  45              


Trp Pro Arg Arg Thr Ala Ser Thr Ser Trp Arg Cys Ser Met Ala Ala 
    50                  55                  60                  


Asn Thr Phe Tyr Phe Arg Pro Asn Gly Ala Gly Asp Thr Arg Gln Asn 
65                  70                  75                  80  


Leu Ile Pro Asp Phe Tyr Ala Phe Arg Val Ile Asn Asn Gly Lys Val 
                85                  90                  95      


Ala Asp Ile Lys Lys Val Asn Asn Phe Ile Arg Glu Gln Asp Leu Tyr 
            100                 105                 110         


Ala Leu Lys Ser Val Lys Ile Pro Val Arg Asn His Gly Ile Leu Met 
        115                 120                 125             


Glu Thr His Lys Glu Leu Lys Pro Leu Leu Ser Pro Ser Ser Glu Thr 
    130                 135                 140                 


Thr Val Thr Val Glu Leu Pro Glu Ala Asp Arg Ala Gly Ala Gly Thr 
145                 150                 155                 160 


Gly Ala Gln Ala Gly Gln Leu Met Gly Phe Phe Lys Gly Ile Asp Gln 
                165                 170                 175     


Asp Ile Glu Arg Ala Val Gln Ser Glu Ile Phe Leu His Glu Ser Tyr 
            180                 185                 190         


Cys Met Asp Thr Ser His Gln Pro Leu Leu Pro Ala Pro Pro Lys Thr 
        195                 200                 205             


Pro Met Asp Gly Ala Asp Cys Gly Ile Gln Trp Trp Asn Ala Val Phe 
    210                 215                 220                 


Ile Met Leu Leu Ile Gly Ile Val Leu Pro Val Phe Tyr Leu Val Tyr 
225                 230                 235                 240 


Phe Lys Ile Gln Ala Ser Gly Glu Thr Pro Asn Ser Leu Asn Thr Thr 
                245                 250                 255     


Val Ile Pro Asn Gly Ser Met Ala Met Gly Thr Val Pro Gly Gln Ala 
            260                 265                 270         


Pro Arg Leu Ala Val Ala Val Pro Ala Val Thr Ser Ala Asp Ser Gln 
        275                 280                 285             


Phe Ser Gln Thr Thr Gln Ala Gly Ser 
    290                 295         


<210>  6062
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  6062

Met Glu Ile Ser Arg Leu Ala Gln Ser Lys Arg Asn Ile Ile Ser Leu 
1               5                   10                  15      


Asn Met Asp Leu Glu Arg Asp Thr Gln Arg Ile Asp Glu Ala Asn Gln 
            20                  25                  30          


Lys Leu Leu Leu Lys Ile Gln Glu Arg Glu Asp Lys Ile Gln Arg Leu 
        35                  40                  45              


Glu Ser Glu Ile Ile Gln Thr Arg Gly Leu Val Glu Asp Glu Glu Trp 
    50                  55                  60                  


Glu Lys Glu Asn Arg Thr Thr Met Glu Arg Glu Arg Ala Leu Gln Glu 
65                  70                  75                  80  


Leu Glu Glu Glu Thr Ala Arg Leu Glu Arg Lys Asn Lys Thr Leu Val 
                85                  90                  95      


His Ser Ile Thr Glu Leu Gln Gln Lys Leu Thr Arg Lys Ser Gln Lys 
            100                 105                 110         


Ile Thr Asn Cys Glu Gln Ser Ser Pro Asp Gly Ala Leu Glu Glu Thr 
        115                 120                 125             


Lys Val Lys Leu Gln Gln Leu Glu Ala Ser Tyr Ala Cys Gln Glu Lys 
    130                 135                 140                 


Glu Leu Leu Lys Val Met Lys Glu Tyr Ala Phe Val Thr Gln Leu Cys 
145                 150                 155                 160 


Glu Asp Gln Ala Leu Tyr Ile Lys Lys Tyr Gln Glu Thr Leu Lys Lys 
                165                 170                 175     


Ile Glu Glu Glu Leu Glu Ala Leu Phe Leu Glu Arg Glu Val Ser Lys 
            180                 185                 190         


Leu Val Ser Met Asn Pro Val Glu Lys Glu His Thr Ser Gln Asn Asn 
        195                 200                 205             


Glu Gly Thr Pro Thr Gln Lys Thr Ala Arg Leu Phe Ser Lys Lys Ile 
    210                 215                 220                 


Phe Cys Cys Leu Phe Phe Ile Thr Leu Phe Phe Ile Arg Leu Leu Ser 
225                 230                 235                 240 


Tyr Met Phe Phe His Val Arg Phe Ile Asn Pro Asp Leu Leu Val Asn 
                245                 250                 255     


Val Leu Pro Lys Val Leu Gly Arg Ser Thr Leu Trp Lys Leu Arg Cys 
            260                 265                 270         


Phe Phe Phe Pro Ser Leu Thr Leu Glu Thr Glu Asp Met Leu Pro His 
        275                 280                 285             


<210>  6063
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  6063

Met Ala Gly Ser His Pro Tyr Phe Asn Gln Pro Asp Ser Thr His Pro 
1               5                   10                  15      


Ser Pro Pro Ser Ala Pro Pro Ser Leu Arg Trp Tyr Gln Arg Cys Gln 
            20                  25                  30          


Pro Ser Asp Ala Thr Ser Gly Leu Leu Val Ala Leu Leu Gly Gly Gly 
        35                  40                  45              


Leu Pro Ala Gly Phe Val Gly Pro Leu Ser Arg Met Ala Tyr Gln Ala 
    50                  55                  60                  


Ser Asn Leu Pro Ser Leu Glu Leu Leu Ile Trp Arg Cys Leu Phe His 
65                  70                  75                  80  


Leu Pro Ile Ala Leu Leu Leu Lys Leu Arg Gly Asp Pro Leu Leu Gly 
                85                  90                  95      


Thr Pro Asp Ile Arg Ser Arg Ala Phe Phe Cys Ala Leu Leu Asn Ile 
            100                 105                 110         


Leu Ser Ile Gly Cys Ala Tyr Ser Ala Val Gln Val Val Pro Ala Gly 
        115                 120                 125             


Asn Ala Ala Thr Val Arg Lys Gly Ser Ser Thr Val Cys Ser Ala Val 
    130                 135                 140                 


Leu Thr Leu Cys Leu Glu Ser Gln Gly Leu Ser Gly Tyr Asp Trp Cys 
145                 150                 155                 160 


Gly Leu Leu Gly Cys Ile Leu Gly Leu Ile Ile Ile Val Gly Pro Gly 
                165                 170                 175     


Leu Trp Thr Leu Gln Glu Gly Thr Thr Gly Val Tyr Thr Ala Leu Gly 
            180                 185                 190         


Tyr Val Glu Ala Phe Leu Gly Gly Leu Ala Leu Ser Leu Arg Leu Leu 
        195                 200                 205             


Val Tyr Arg Ser Leu His Phe Pro Pro Cys Leu Pro Thr Val Ala Phe 
    210                 215                 220                 


Leu Ser Gly Leu Val Gly Leu Leu Gly Ser Val Pro Gly Leu Phe Val 
225                 230                 235                 240 


Leu Gln Ala Pro Val Leu Pro Ser Asp Leu Leu Ser Trp Ser Cys Val 
                245                 250                 255     


Gly Ala Val Gly Ile Leu Ala Leu Val Ser Phe Thr Cys Val Gly Tyr 
            260                 265                 270         


Ala Val Thr Lys Ala His Pro Ala Leu Val Cys Ala Val Leu His Ser 
        275                 280                 285             


Glu Val Val Val Ala Leu Ile Leu Gln Tyr Tyr Met Leu His Glu Thr 
    290                 295                 300                 


Val Ala Pro Ser Asp Ile Val Ala Ala Gly Val Val Leu Gly Ser Ile 
305                 310                 315                 320 


Ala Ile Ile Thr Ala Gln Asn Leu Ser Cys Glu Arg Thr Gly Arg Val 
                325                 330                 335     


Glu Glu 
        


<210>  6064
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  6064

Met Ala Ser Ser Leu Leu Ala Gly Glu Arg Leu Val Arg Ala Leu Gly 
1               5                   10                  15      


Pro Gly Gly Glu Leu Glu Pro Glu Arg Leu Pro Arg Lys Leu Arg Ala 
            20                  25                  30          


Glu Leu Glu Ala Ala Leu Gly Lys Lys His Lys Gly Gly Asp Ser Ser 
        35                  40                  45              


Ser Gly Pro Gln Arg Leu Val Ser Phe Arg Leu Ile Arg Asp Leu His 
    50                  55                  60                  


Gln His Leu Arg Glu Arg Asp Ser Lys Leu Tyr Leu His Glu Leu Leu 
65                  70                  75                  80  


Glu Gly Ser Glu Ile Tyr Leu Pro Glu Val Val Lys Pro Pro Arg Asn 
                85                  90                  95      


Pro Glu Leu Val Ala Arg Leu Glu Lys Ile Lys Ile Gln Leu Ala Asn 
            100                 105                 110         


Glu Glu Tyr Lys Arg Ile Thr Arg Asn Val Thr Cys Gln Asp Thr Arg 
        115                 120                 125             


His Gly Gly Thr Leu Ser Asp Leu Gly Lys Gln Val Arg Ser Leu Lys 
    130                 135                 140                 


Ala Leu Val Ile Thr Ile Phe Asn Phe Ile Val Thr Val Val Ala Ala 
145                 150                 155                 160 


Phe Val Cys Thr Tyr Leu Gly Ser Gln Tyr Ile Phe Thr Glu Met Ala 
                165                 170                 175     


Ser Arg Val Leu Ala Ala Leu Ile Val Ala Ser Val Val Gly Leu Ala 
            180                 185                 190         


Glu Leu Tyr Val Met Val Arg Ala Met Glu Gly Glu Leu Gly Glu Leu 
        195                 200                 205             


<210>  6065
<211>  726
<212>  PRT
<213>  Homo sapiens

<400>  6065

Met Leu Leu Pro Arg Ser Val Ser Ser Glu Arg Ala Pro Gly Val Pro 
1               5                   10                  15      


Glu Pro Glu Glu Leu Trp Glu Ala Glu Met Glu Arg Leu Arg Gly Ser 
            20                  25                  30          


Gly Thr Pro Val Arg Gly Leu Pro Tyr Ala Met Met Asp Lys Arg Leu 
        35                  40                  45              


Ile Trp Gln Leu Arg Glu Pro Ala Gly Val Gln Thr Leu Arg Trp Gln 
    50                  55                  60                  


Arg Trp Gln Arg Arg Arg Gln Thr Val Glu Arg Arg Leu Arg Glu Ala 
65                  70                  75                  80  


Ala Gln Arg Leu Ala Arg Gly Leu Gly Leu Trp Glu Gly Ala Leu Tyr 
                85                  90                  95      


Glu Ile Gly Gly Leu Phe Gly Thr Gly Ile Arg Ser Tyr Phe Thr Phe 
            100                 105                 110         


Leu Arg Phe Leu Leu Leu Leu Asn Leu Leu Ser Leu Leu Leu Thr Ala 
        115                 120                 125             


Ser Phe Val Leu Leu Pro Leu Val Trp Leu Arg Pro Pro Asp Pro Gly 
    130                 135                 140                 


Pro Thr Leu Asn Leu Thr Leu Gln Cys Pro Gly Ser Arg Gln Ser Pro 
145                 150                 155                 160 


Pro Gly Val Leu Arg Phe His Asn Gln Leu Trp His Val Leu Thr Gly 
                165                 170                 175     


Arg Ala Phe Thr Asn Thr Tyr Leu Phe Tyr Gly Ala Tyr Arg Val Gly 
            180                 185                 190         


Pro Glu Ser Ser Ser Val Tyr Ser Ile Arg Leu Ala Tyr Leu Leu Ser 
        195                 200                 205             


Pro Leu Ala Cys Leu Leu Leu Cys Phe Cys Gly Thr Leu Arg Arg Met 
    210                 215                 220                 


Val Lys Gly Leu Pro Gln Lys Thr Leu Leu Gly Gln Gly Tyr Gln Ala 
225                 230                 235                 240 


Pro Leu Ser Ala Lys Val Phe Ser Ser Trp Asp Phe Cys Ile Arg Val 
                245                 250                 255     


Gln Glu Ala Ala Thr Ile Lys Lys His Glu Ile Ser Asn Glu Phe Lys 
            260                 265                 270         


Val Glu Leu Glu Glu Gly Arg Arg Phe Gln Leu Met Gln Gln Gln Thr 
        275                 280                 285             


Arg Ala Gln Thr Ala Cys Arg Leu Leu Ser Tyr Leu Arg Val Asn Val 
    290                 295                 300                 


Leu Asn Gly Leu Leu Val Val Gly Ala Ile Ser Ala Ile Phe Trp Ala 
305                 310                 315                 320 


Thr Lys Tyr Ser Gln Asp Asn Lys Glu Glu Ser Leu Phe Leu Leu Leu 
                325                 330                 335     


Gln Tyr Leu Pro Pro Gly Val Ile Ala Leu Val Asn Phe Leu Gly Pro 
            340                 345                 350         


Leu Leu Phe Thr Phe Leu Val Gln Leu Glu Asn Tyr Pro Pro Asn Thr 
        355                 360                 365             


Glu Val Asn Leu Thr Leu Ile Trp Cys Val Val Leu Lys Leu Ala Ser 
    370                 375                 380                 


Leu Gly Met Phe Ser Val Ser Leu Gly Gln Thr Ile Leu Cys Ile Gly 
385                 390                 395                 400 


Arg Asp Lys Ser Ser Cys Glu Ser Tyr Gly Tyr Asn Val Cys Asp Tyr 
                405                 410                 415     


Gln Cys Trp Glu Asn Ser Val Gly Glu Glu Leu Tyr Lys Leu Ser Ile 
            420                 425                 430         


Phe Asn Phe Leu Leu Thr Val Ala Phe Ala Phe Leu Val Thr Leu Pro 
        435                 440                 445             


Arg Arg Leu Leu Val Asp Arg Phe Ser Gly Arg Phe Trp Ala Trp Leu 
    450                 455                 460                 


Glu Arg Glu Glu Phe Leu Val Pro Lys Asn Val Leu Asp Ile Val Ala 
465                 470                 475                 480 


Gly Gln Thr Val Thr Trp Met Gly Leu Phe Tyr Cys Pro Leu Leu Pro 
                485                 490                 495     


Leu Leu Asn Ser Val Phe Leu Phe Leu Thr Phe Tyr Ile Lys Lys Tyr 
            500                 505                 510         


Thr Leu Leu Lys Asn Ser Arg Ala Ser Ser Arg Pro Phe Arg Ala Ser 
        515                 520                 525             


Ser Ser Thr Phe Phe Phe Gln Leu Val Leu Leu Leu Gly Leu Leu Leu 
    530                 535                 540                 


Ala Ala Val Pro Leu Gly Tyr Val Val Ser Ser Ile His Ser Ser Trp 
545                 550                 555                 560 


Asp Cys Gly Leu Phe Thr Asn Tyr Ser Ala Pro Trp Gln Val Val Pro 
                565                 570                 575     


Glu Leu Val Ala Leu Gly Leu Pro Pro Ile Gly Gln Arg Ala Leu His 
            580                 585                 590         


Tyr Leu Gly Ser His Ala Phe Ser Phe Pro Leu Leu Ile Met Leu Ser 
        595                 600                 605             


Leu Val Leu Thr Val Cys Val Ser Gln Thr Gln Ala Asn Ala Arg Ala 
    610                 615                 620                 


Ile His Arg Leu Arg Lys Gln Leu Val Trp Gln Val Gln Glu Lys Trp 
625                 630                 635                 640 


His Leu Val Glu Asp Leu Ser Arg Leu Leu Pro Glu Pro Gly Pro Ser 
                645                 650                 655     


Asp Ser Pro Gly Pro Lys Tyr Pro Ala Ser Gln Ala Ser Arg Pro Gln 
            660                 665                 670         


Ser Phe Cys Pro Gly Cys Pro Cys Pro Gly Ser Pro Gly His Gln Ala 
        675                 680                 685             


Pro Arg Pro Gly Pro Ser Val Val Asp Ala Ala Gly Leu Arg Ser Pro 
    690                 695                 700                 


Cys Pro Gly Gln His Gly Ala Pro Ala Ser Ala Arg Arg Phe Arg Phe 
705                 710                 715                 720 


Pro Ser Gly Ala Glu Leu 
                725     


<210>  6066
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  6066

Met Asp Lys Val Gln Ser Gly Phe Leu Ile Leu Phe Leu Phe Leu Met 
1               5                   10                  15      


Glu Cys Gln Leu His Leu Cys Leu Pro Tyr Ala Asp Gly Leu His Pro 
            20                  25                  30          


Thr Gly Asn Ile Thr Gly Leu Pro Gly Ser Lys Arg Ser Gln Pro Pro 
        35                  40                  45              


Arg Asn Ile Thr Lys Glu Pro Lys Val Phe Phe His Lys Thr Gln Leu 
    50                  55                  60                  


Pro Gly Ile Gln Gly Ala Ala Ser Arg Ser Thr Ala Ala Ser Pro Thr 
65                  70                  75                  80  


Asn Pro Met Lys Phe Leu Arg Asn Lys Ala Ile Ile Arg His Arg Pro 
                85                  90                  95      


Ala Leu Val Lys Val Ile Leu Ile Ser Ser Val Ala Phe Ser Ile Ala 
            100                 105                 110         


Leu Ile Cys Gly Met Ala Ile Ser Tyr Met Ile Tyr Arg Leu Ala Gln 
        115                 120                 125             


Ala Glu Glu Arg Gln Gln Leu Glu Ser Leu Tyr Lys Asn Leu Arg Ile 
    130                 135                 140                 


Pro Leu Leu Gly Asp Glu Glu Glu Gly Ser Glu Asp Glu Gly Glu Ser 
145                 150                 155                 160 


Thr His Leu Leu Pro Glu Asn Glu Asn Glu Leu Glu Lys Phe Ile His 
                165                 170                 175     


Ser Val Ile Ile Ser Lys Arg Ser Lys Asn Ile Lys Lys Lys Leu Lys 
            180                 185                 190         


Glu Glu Gln Asn Ser Val Thr Glu Asn Lys Thr Lys Asn Ala Ser His 
        195                 200                 205             


Asn Gly Lys Met Glu Asp Leu 
    210                 215 


<210>  6067
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  6067

Met Pro Pro Met Leu Trp Leu Leu Leu His Phe Ala Ala Pro Ala Leu 
1               5                   10                  15      


Gly Phe Tyr Phe Ser Ile Ser Cys Pro Ser Gly Lys Gln Cys Gln Gln 
            20                  25                  30          


Ala Leu Leu Ser Gly Asn Asp Ile Leu Leu Tyr Cys Asn Ser Ser Gly 
        35                  40                  45              


Ala His Trp Tyr Tyr Leu Phe Thr Gln Gly Lys Lys Gly Arg Leu Thr 
    50                  55                  60                  


Ser Leu Thr Asn Ile Ser Asn Met Glu Ile Met Pro Glu Gly Ser Leu 
65                  70                  75                  80  


Leu Ile Lys Asp Pro Leu Pro Ser Gln Thr Gly Leu Tyr His Cys Trp 
                85                  90                  95      


Asn Lys Asn Gly Arg Gln Val Val Gln Tyr Glu Ile Asp Phe Gln Asp 
            100                 105                 110         


Val Thr Thr Leu His Ile Thr His Lys Asp Leu Gly Gln Arg Pro Leu 
        115                 120                 125             


Gln Asn Glu Thr Leu His Leu Gly Ser Lys Gln Leu Ile Phe Thr Trp 
    130                 135                 140                 


Trp Glu Pro Trp Gln Asp Cys Asn Arg Cys Glu Glu Pro Gly Glu Cys 
145                 150                 155                 160 


Lys Arg Leu Gly Tyr Arg Tyr Ile Glu Glu Pro Leu Glu Glu Ala Met 
                165                 170                 175     


Pro Cys Trp Leu Tyr Leu Gly Glu Val Leu Val Trp Ser Ser Arg Leu 
            180                 185                 190         


Arg Pro Glu Leu Gln Val Glu Ala Cys His Val Gln Cys Thr Asn Asn 
        195                 200                 205             


Thr Gln Leu Arg Val Asp Tyr Val Ile Phe Asp Asn Phe Arg Leu Asp 
    210                 215                 220                 


Glu Lys Thr Glu Phe Val Trp Leu Asp Cys Pro Leu Gly Ser Met Tyr 
225                 230                 235                 240 


Arg Pro Val Asn Trp Arg Ala Asn Asp Thr Pro Leu Thr Trp Glu Ser 
                245                 250                 255     


Gln Leu Ser Gly Gln Asp Phe Thr Thr Phe Leu Asp Pro Ser Thr Gly 
            260                 265                 270         


Gly Arg Gln Leu Gln Val Phe Gln Pro Ala Val Tyr Lys Cys Phe Val 
        275                 280                 285             


Gln Gln Glu Leu Val Ala Gln Phe Lys Pro Ala Ala Ser Leu Glu Thr 
    290                 295                 300                 


Leu Glu Ala Gln Trp Arg Glu Asn Asp Ala Gln Trp Arg Glu Ala Arg 
305                 310                 315                 320 


Lys Ala Leu Arg Gly Arg Ala Asp Ser Val Leu Lys Gly Leu Lys Leu 
                325                 330                 335     


Val Leu Leu Val Val Thr Val Leu Ala Leu Leu Gly Ala Leu Leu Lys 
            340                 345                 350         


Cys Ile His Pro Ser Pro Gly Arg Arg Ser Thr Gln Val Leu Val Val 
        355                 360                 365             


Lys 
    


<210>  6068
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  6068

Met Glu Ile Asn Thr Lys Leu Leu Ile Ser Val Thr Cys Ile Ser Phe 
1               5                   10                  15      


Phe Thr Phe Gln Leu Leu Phe Tyr Phe Val Ser Tyr Trp Phe Ser Ala 
            20                  25                  30          


Lys Val Ser Pro Gly Phe Asn Ser Leu Ser Phe Lys Lys Lys Ile Glu 
        35                  40                  45              


Trp Asn Ser Arg Val Val Ser Thr Cys His Ser Leu Val Val Gly Ile 
    50                  55                  60                  


Phe Gly Leu Tyr Ile Phe Leu Phe Asp Glu Ala Thr Lys Ala Asp Pro 
65                  70                  75                  80  


Leu Trp Gly Gly Pro Ser Leu Ala Asn Val Asn Ile Ala Ile Ala Ser 
                85                  90                  95      


Gly Tyr Leu Ile Ser Asp Leu Ser Ile Ile Ile Leu Tyr Trp Lys Val 
            100                 105                 110         


Ile Gly Asp Lys Phe Phe Ile Met His His Cys Ala Ser Leu Tyr Ala 
        115                 120                 125             


Tyr Tyr Leu Val Leu Lys Asn Gly Val Leu Ala Tyr Ile Gly Asn Phe 
    130                 135                 140                 


Arg Leu Leu Ala Glu Leu Ser Ser Pro Phe Val Asn Gln Arg Trp Phe 
145                 150                 155                 160 


Phe Glu Ala Leu Lys Tyr Pro Lys Phe Ser Lys Ala Ile Val Ile Asn 
                165                 170                 175     


Gly Ile Leu Met Thr Val Val Phe Phe Ile Val Arg Ile Ala Ser Met 
            180                 185                 190         


Leu Pro His Tyr Gly Phe Met Tyr Ser Val Tyr Gly Thr Glu Pro Tyr 
        195                 200                 205             


Ile Arg Leu Gly Val Leu Ile Gln Leu Ser Trp Val Ile Ser Cys Val 
    210                 215                 220                 


Val Leu Asp Val Met Asn Val Met Trp Met Ile Lys Ile Ser Lys Gly 
225                 230                 235                 240 


Cys Ile Lys Val Ile Ser His Ile Arg Gln Glu Lys Ala Lys Asn Ser 
                245                 250                 255     


Leu Gln Asn Gly Lys Leu Asp 
            260             


<210>  6069
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  6069

Met Ala Gln Arg Cys Val Cys Val Leu Ala Leu Val Ala Met Leu Leu 
1               5                   10                  15      


Leu Val Phe Pro Thr Val Ser Arg Ser Met Gly Pro Arg Ser Gly Glu 
            20                  25                  30          


His Gln Arg Ala Ser Arg Ile Pro Ser Gln Phe Ser Lys Glu Glu Arg 
        35                  40                  45              


Val Ala Met Lys Glu Ala Leu Lys Gly Ala Ile Gln Ile Pro Thr Val 
    50                  55                  60                  


Thr Phe Ser Ser Glu Lys Ser Asn Thr Thr Ala Leu Ala Glu Phe Gly 
65                  70                  75                  80  


Lys Tyr Ile His Lys Val Phe Pro Thr Val Val Ser Thr Ser Phe Ile 
                85                  90                  95      


Gln His Glu Val Val Glu Glu Tyr Ser His Leu Phe Thr Ile Gln Gly 
            100                 105                 110         


Ser Asp Pro Ser Leu Gln Pro Tyr Leu Leu Met Ala His Phe Asp Val 
        115                 120                 125             


Val Pro Ala Pro Glu Glu Gly Trp Glu Val Pro Pro Phe Ser Gly Leu 
    130                 135                 140                 


Glu Arg Asp Gly Ile Ile Tyr Gly Arg Gly Thr Leu Asp Asp Lys Asn 
145                 150                 155                 160 


Ser Val Met Ala Leu Leu Gln Ala Leu Glu Leu Leu Leu Ile Arg Lys 
                165                 170                 175     


Tyr Ile Pro Arg Arg Ser Phe Phe Ile Ser Leu Gly His Asp Glu Glu 
            180                 185                 190         


Ser Ser Gly Thr Gly Ala Gln Arg Ile Ser Ala Leu Leu Gln Ser Arg 
        195                 200                 205             


Gly Val Gln Leu Ala Phe Ile Val Asp Glu Gly Gly Phe Ile Leu Asp 
    210                 215                 220                 


Asp Phe Ile Pro Asn Phe Lys Lys Pro Ile Ala Leu Ile Ala Val Ser 
225                 230                 235                 240 


Glu Lys Gly Ser Met Asn Leu Met Leu Gln Val Asn Met Thr Ser Gly 
                245                 250                 255     


His Ser Ser Ala Pro Pro Lys Glu Thr Ser Ile Gly Ile Leu Ala Ala 
            260                 265                 270         


Ala Val Ser Arg Leu Glu Gln Thr Pro Met Pro Ile Ile Phe Gly Ser 
        275                 280                 285             


Gly Thr Val Val Thr Val Leu Gln Gln Leu Ala Asn Glu Phe Pro Phe 
    290                 295                 300                 


Pro Val Asn Ile Ile Leu Ser Asn Pro Trp Leu Phe Glu Pro Leu Ile 
305                 310                 315                 320 


Ser Arg Phe Met Glu Arg Asn Pro Leu Thr Asn Ala Ile Ile Arg Thr 
                325                 330                 335     


Thr Thr Ala Leu Thr Ile Phe Lys Ala Gly Val Lys Phe Asn Val Ile 
            340                 345                 350         


Pro Pro Val Ala Gln Ala Thr Val Asn Phe Arg Ile His Pro Gly Gln 
        355                 360                 365             


Thr Val Gln Glu Val Leu Glu Leu Thr Lys Asn Ile Val Ala Asp Asn 
    370                 375                 380                 


Arg Val Gln Phe His Val Leu Ser Ala Phe Asp Pro Leu Pro Val Ser 
385                 390                 395                 400 


Pro Ser Asp Asp Lys Ala Leu Gly Tyr Gln Leu Leu Arg Gln Thr Val 
                405                 410                 415     


Gln Ser Val Phe Pro Glu Val Asn Ile Thr Ala Pro Val Thr Ser Ile 
            420                 425                 430         


Gly Asn Thr Asp Ser Arg Phe Phe Thr Asn Leu Thr Thr Gly Ile Tyr 
        435                 440                 445             


Arg Phe Tyr Pro Ile Tyr Ile Gln Pro Glu Asp Phe Lys Arg Ile His 
    450                 455                 460                 


Gly Val Asn Glu Lys Ile Ser Val Gln Ala Tyr Glu Thr Gln Val Lys 
465                 470                 475                 480 


Phe Ile Phe Glu Leu Ile Gln Asn Ala Asp Thr Asp Gln Glu Pro Val 
                485                 490                 495     


Ser His Leu His Lys Leu 
            500         


<210>  6070
<211>  706
<212>  PRT
<213>  Homo sapiens

<400>  6070

Met Asp Ile Lys His His Gln Asn Gly Thr Arg Gly Gln Arg Arg Lys 
1               5                   10                  15      


Gln Pro His Thr Thr Val Gln Arg Leu Leu Thr Trp Gly Leu Pro Val 
            20                  25                  30          


Ser Cys Ser Trp Phe Leu Trp Arg Gln Pro Gly Glu Phe Pro Val Thr 
        35                  40                  45              


Ala Leu Leu Leu Gly Ala Gly Ala Gly Gly Leu Leu Ala Ile Gly Leu 
    50                  55                  60                  


Phe Gln Leu Leu Val Asn Pro Met Asn Ile Tyr Glu Glu Gln Lys Ile 
65                  70                  75                  80  


Met Phe Leu Tyr Ser Leu Val Gly Leu Gly Ala Met Gly Trp Gly Thr 
                85                  90                  95      


Ser Pro His Ile Arg Cys Ala Ser Leu Leu Leu Val Pro Lys Met Leu 
            100                 105                 110         


Gly Lys Glu Gly Arg Leu Phe Val Leu Gly Tyr Ala Leu Ala Ala Ile 
        115                 120                 125             


Tyr Val Gly Pro Val Ala Asn Leu Arg His Asn Leu Asn Asn Val Ile 
    130                 135                 140                 


Ala Ser Leu Gly Cys Thr Val Glu Leu Gln Ile Asn Asn Thr Arg Ala 
145                 150                 155                 160 


Ala Trp Arg Ile Ser Thr Ala Pro Leu Arg Ala Met Phe Lys Asp Leu 
                165                 170                 175     


Leu Ser Ser Lys Glu Leu Leu Arg Ala Glu Thr Arg Asn Ile Ser Ala 
            180                 185                 190         


Thr Phe Glu Asp Leu Asp Ala Gln Val Asn Ser Glu Thr Gly Tyr Thr 
        195                 200                 205             


Pro Glu Asp Thr Met Asp Ser Gly Glu Thr Ala Gln Gly Arg Glu Ala 
    210                 215                 220                 


Arg Gln Ala Pro Ala Ser Arg Leu His Leu Ser Thr Gln Lys Met Tyr 
225                 230                 235                 240 


Glu Leu Lys Thr Lys Leu Arg Cys Ser Tyr Val Val Asn Gln Ala Ile 
                245                 250                 255     


Leu Ser Cys Arg Arg Trp Phe Asp Arg Lys His Glu Gln Cys Met Lys 
            260                 265                 270         


His Ile Trp Val Pro Leu Leu Thr His Leu Leu Cys Leu Pro Met Lys 
        275                 280                 285             


Phe Lys Phe Phe Cys Gly Ile Ala Lys Val Met Glu Val Trp Cys Arg 
    290                 295                 300                 


Asn Arg Ile Pro Val Glu Gly Asn Phe Gly Gln Thr Tyr Asp Ser Leu 
305                 310                 315                 320 


Asn Gln Ser Ile Arg Gly Leu Asp Gly Glu Phe Ser Ala Asn Ile Asp 
                325                 330                 335     


Phe Lys Glu Glu Lys Gln Ala Gly Val Leu Gly Leu Asn Thr Ser Trp 
            340                 345                 350         


Glu Arg Val Ser Thr Glu Val Arg Asp Tyr Val Tyr Arg Gln Glu Ala 
        355                 360                 365             


Arg Leu Glu Trp Ala Leu Gly Leu Leu His Val Leu Leu Ser Cys Thr 
    370                 375                 380                 


Phe Leu Leu Val Leu His Ala Ser Phe Ser Tyr Met Asp Ser Tyr Asn 
385                 390                 395                 400 


His Asp Ile Arg Phe Asp Asn Ile Tyr Ile Ser Thr Tyr Phe Cys Gln 
                405                 410                 415     


Ile Asp Asp Arg Arg Lys Lys Leu Gly Lys Arg Thr Leu Leu Pro Leu 
            420                 425                 430         


Arg Lys Ala Glu Glu Lys Thr Val Ile Phe Pro Cys Lys Pro Thr Ile 
        435                 440                 445             


Gln Ala Ser Glu Met Ser Asn Val Val Arg Glu Leu Leu Glu Thr Leu 
    450                 455                 460                 


Pro Ile Leu Leu Leu Leu Val Val Leu Cys Gly Leu Asp Trp Ala Leu 
465                 470                 475                 480 


Tyr Ser Ile Phe Asp Thr Ile Arg His His Ser Phe Leu Gln Tyr Ser 
                485                 490                 495     


Phe Arg Ser Ser His Lys Leu Glu Val Lys Val Gly Gly Asp Ser Met 
            500                 505                 510         


Leu Ala Arg Leu Leu Arg Lys Thr Ile Gly Ala Leu Asn Thr Ser Ser 
        515                 520                 525             


Glu Thr Val Met Glu Ser Asn Asn Met Pro Cys Leu Pro Gln Pro Val 
    530                 535                 540                 


Gly Leu Asp Ala Arg Ala Tyr Trp Arg Ala Ala Val Pro Ile Gly Leu 
545                 550                 555                 560 


Leu Val Cys Leu Cys Leu Leu Gln Ala Phe Gly Tyr Arg Leu Arg Arg 
                565                 570                 575     


Val Ile Ala Ala Phe Tyr Phe Pro Lys Arg Glu Lys Lys Arg Ile Leu 
            580                 585                 590         


Phe Leu Tyr Asn Asp Leu Leu Lys Lys Arg Ala Ala Phe Thr Lys Leu 
        595                 600                 605             


Arg Arg Ala Ala Ile Leu Arg Arg Glu Arg Gln Gln Lys Ala Pro Arg 
    610                 615                 620                 


His Pro Leu Ala Asp Ile Leu His Arg Gly Cys Pro Leu Leu Arg Arg 
625                 630                 635                 640 


Trp Leu Cys Arg Arg Cys Val Val Cys Gln Ala Pro Glu Thr Pro Glu 
                645                 650                 655     


Ser Tyr Val Cys Arg Thr Leu Asp Cys Glu Ala Val Tyr Cys Trp Ser 
            660                 665                 670         


Cys Trp Asp Asp Met Arg Gln Arg Cys Pro Val Cys Thr Pro Arg Glu 
        675                 680                 685             


Glu Leu Ser Ser Ser Ala Phe Ser Asp Ser Asn Asp Asp Thr Ala Tyr 
    690                 695                 700                 


Ala Gly 
705     


<210>  6071
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  6071

Met Ala Phe Thr Phe Ala Ala Phe Cys Tyr Met Leu Ser Leu Val Leu 
1               5                   10                  15      


Cys Ala Ala Leu Ile Phe Phe Ala Ile Trp His Ile Ile Ala Phe Asp 
            20                  25                  30          


Glu Leu Arg Thr Asp Phe Lys Ser Pro Ile Asp Gln Cys Asn Pro Val 
        35                  40                  45              


His Ala Arg Glu Arg Leu Arg Asn Ile Glu Arg Ile Cys Phe Leu Leu 
    50                  55                  60                  


Arg Lys Leu Val Leu Pro Glu Tyr Ser Ile His Ser Leu Phe Cys Ile 
65                  70                  75                  80  


Met Phe Leu Cys Ala Gln Glu Trp Leu Thr Leu Gly Leu Asn Val Pro 
                85                  90                  95      


Leu Leu Phe Tyr His Phe Trp Arg Tyr Phe His Cys Pro Ala Asp Ser 
            100                 105                 110         


Ser Glu Leu Ala Tyr Asp Pro Pro Val Val Met Asn Ala Asp Thr Leu 
        115                 120                 125             


Ser Tyr Cys Gln Lys Glu Ala Trp Cys Lys Leu Ala Phe Tyr Leu Leu 
    130                 135                 140                 


Ser Phe Phe Tyr Tyr Leu Tyr Cys Met Ile Tyr Thr Leu Val Ser Ser 
145                 150                 155                 160 


<210>  6072
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  6072

Met Ile Thr Gly Ser Pro Gln Met Thr Trp Cys Pro Pro Phe Trp Thr 
1               5                   10                  15      


Pro Pro Ile Ser Thr Ala Ser Arg Tyr Gly Ser His Gly Ala Phe Tyr 
            20                  25                  30          


Arg Tyr Lys Asn Ser Met Gly Lys Ser Leu Pro Leu Phe Tyr Ile Tyr 
        35                  40                  45              


Asp Ser Tyr Leu Thr Ser Pro Glu Ala Trp Ala His Leu Leu Thr Pro 
    50                  55                  60                  


Asn Gly Pro His Ser Ile Arg Asn Thr Pro Tyr Asp Gly Val Phe Ile 
65                  70                  75                  80  


Ala Leu Leu Val Glu Glu Gly His Thr His Asp Ile Leu Ala Ala Gly 
                85                  90                  95      


Phe Asp Gly Met Tyr Thr Tyr Phe Ala Ser Asn Gly Phe Ser Phe Gly 
            100                 105                 110         


Ser Ser His Gln Asn Trp Lys Ala Val Lys Asn Phe Cys Asp Ala Asn 
        115                 120                 125             


Asn Leu Met Phe Ile Pro Ser Val Gly Pro Gly Tyr Ile Asp Thr Ser 
    130                 135                 140                 


Ile Arg Pro Trp Asn Asn His Asn Thr Arg Asn Arg Val Asn Gly Lys 
145                 150                 155                 160 


Tyr Tyr Glu Thr Ala Leu Gln Ala Ala Leu Thr Val Arg Pro Glu Ile 
                165                 170                 175     


Val Ser Ile Thr Ser Phe Asn Glu Trp His Glu Gly Thr Gln Ile Glu 
            180                 185                 190         


Lys Ala Ile Pro Lys Lys Thr Pro Thr Arg Leu Tyr Leu Asp Tyr Leu 
        195                 200                 205             


Pro His Gln Pro Ser Leu Tyr Leu Glu Leu Thr Arg Arg Trp Ala Glu 
    210                 215                 220                 


His Phe Ile Lys Glu Lys Glu Gln Trp Leu Met 
225                 230                 235 


<210>  6073
<211>  987
<212>  PRT
<213>  Homo sapiens

<400>  6073

Met Thr Pro Ala Leu Arg Glu Ala Thr Ala Lys Gly Ile Ser Phe Ser 
1               5                   10                  15      


Ser Leu Pro Ser Thr Met Glu Ser Asp Lys Met Leu Tyr Met Glu Ser 
            20                  25                  30          


Pro Arg Thr Val Asp Glu Lys Leu Lys Gly Asp Thr Phe Ser Gln Met 
        35                  40                  45              


Leu Gly Phe Pro Thr Pro Glu Pro Thr Leu Asn Thr Asn Phe Val Asn 
    50                  55                  60                  


Leu Lys His Phe Gly Ser Pro Gln Ser Ser Lys His Tyr Gln Thr Val 
65                  70                  75                  80  


Phe Leu Met Arg Ser Asn Ser Thr Leu Asn Lys His Asn Glu Asn Tyr 
                85                  90                  95      


Lys Gln Lys Lys Leu Gly Glu Pro Ser Cys Asn Lys Leu Lys Asn Ile 
            100                 105                 110         


Leu Tyr Asn Gly Ser Asn Ile Gln Leu Ser Lys Ile Cys Leu Ser His 
        115                 120                 125             


Ser Glu Glu Phe Ile Lys Lys Glu Pro Leu Ser Asp Thr Thr Ser Gln 
    130                 135                 140                 


Cys Met Lys Asp Val Gln Ile Ile Leu Asp Ser Asn Ile Thr Lys Asp 
145                 150                 155                 160 


Thr Asn Val Asp Lys Val Gln Leu Gln Asn Cys Lys Trp Tyr Gln Glu 
                165                 170                 175     


Asn Ala Leu Leu Asp Lys Val Thr Asp Ala Glu Ile Lys Lys Gly Leu 
            180                 185                 190         


Leu His Cys Thr Gln Lys Lys Ile Val Pro Gly His Ser Asn Val Pro 
        195                 200                 205             


Val Ser Ser Ser Ala Ala Glu Lys Glu Glu Glu Val His Ala Arg Leu 
    210                 215                 220                 


Leu His Cys Val Ser Lys Gln Lys Ile Leu Leu Ser Gln Ala Arg Arg 
225                 230                 235                 240 


Thr Gln Lys His Leu Gln Met Leu Leu Ala Lys His Val Val Lys His 
                245                 250                 255     


Tyr Gly Gln Gln Met Lys Leu Ser Met Lys His Gln Leu Pro Lys Met 
            260                 265                 270         


Lys Thr Phe His Glu Pro Thr Thr Ile Leu Gly Asn Ser Leu Pro Lys 
        275                 280                 285             


Cys Thr Glu Ile Lys Pro Glu Val Asn Thr Leu Thr Ala Glu Asn Lys 
    290                 295                 300                 


Leu Trp Asp Asp Ala Lys Asn Gly Phe Ala Arg Cys Thr Ala Ala Glu 
305                 310                 315                 320 


Ile Gln Arg Phe Ala Phe Ser Ala Thr Gly Leu Leu Ser His Val Glu 
                325                 330                 335     


Glu Gly Leu Asp Ser Asp Ala Thr Asp Ser Ser Ser Asp Asp Asp Leu 
            340                 345                 350         


Asp Glu Tyr Thr Leu Arg Lys Asn Val Ala Val Asn Cys Ser Thr Glu 
        355                 360                 365             


Trp Lys Trp Leu Val Asp Arg Ala Arg Val Gly Ser Arg Trp Thr Trp 
    370                 375                 380                 


Leu Gln Ala Gln Ile Ser Asp Leu Glu Cys Lys Ile Gln Gln Leu Thr 
385                 390                 395                 400 


Asp Ile His Arg Gln Ile Arg Ala Ser Lys Gly Ile Val Val Leu Glu 
                405                 410                 415     


Glu Cys Gln Leu Pro Lys Asp Ile Leu Lys Lys Gln Met Gln Phe Ala 
            420                 425                 430         


Asp Gln Ala Ala Ser Leu Asn Ile Leu Gly Asn Pro Gln Val Pro Gln 
        435                 440                 445             


Glu Cys Gln Asp Pro Val Pro Glu Gln Asp Phe Glu Met Ser Pro Ser 
    450                 455                 460                 


Ser Pro Thr Leu Leu Leu Arg Asn Ile Glu Lys Gln Ser Ala Gln Leu 
465                 470                 475                 480 


Thr Glu Ile Ile Asn Ser Leu Ile Ala Pro Leu Asn Leu Ser Pro Thr 
                485                 490                 495     


Ser Ser Pro Leu Ser Ser Lys Ser Cys Ser His Lys Cys Leu Ala Asn 
            500                 505                 510         


Gly Ile Tyr Arg Ser Ala Ser Glu Asn Leu Asp Glu Leu Ser Ser Ser 
        515                 520                 525             


Ser Ser Trp Leu Leu Asn Gln Lys His Ser Lys Lys Lys Arg Lys Asp 
    530                 535                 540                 


Arg Thr Arg Leu Lys Ser Ser Ser Leu Thr Phe Met Ser Thr Ser Ala 
545                 550                 555                 560 


Arg Thr Arg Pro Leu Gln Ser Phe His Lys Arg Lys Leu Tyr Arg Leu 
                565                 570                 575     


Ser Pro Thr Phe Tyr Trp Thr Pro Gln Thr Leu Pro Ser Lys Glu Thr 
            580                 585                 590         


Ala Phe Leu Asn Thr Thr Gln Met Pro Cys Leu Gln Ser Ala Ser Thr 
        595                 600                 605             


Trp Ser Ser Tyr Glu His Asn Ser Glu Ser Tyr Leu Leu Arg Glu His 
    610                 615                 620                 


Val Ser Glu Leu Asp Ser Ser Phe His Ser Val Leu Ser Leu Pro Ser 
625                 630                 635                 640 


Asp Val Pro Leu His Phe His Phe Glu Thr Leu Leu Lys Lys Thr Glu 
                645                 650                 655     


Ile Lys Gly Asn Leu Ala Glu Asn Lys Phe Val Asp Glu Tyr Ile Ile 
            660                 665                 670         


Ser Pro Ser Pro Val His Ser Thr Leu Asn Gln Trp Arg Asn Gly Tyr 
        675                 680                 685             


Ser Pro Ile Cys Lys Pro Gln Ile Arg Ser Glu Ser Ser Ala Gln Leu 
    690                 695                 700                 


Leu Gln Gly Arg Lys Lys Arg His Leu Ser Glu Thr Ala Leu Gly Glu 
705                 710                 715                 720 


Arg Thr Lys Leu Glu Glu Ser Asp Phe Gln His Thr Glu Ser Gly Ser 
                725                 730                 735     


His Ser Asn Phe Thr Ala Val Ser Asn Val Asn Val Leu Ser Arg Ile 
            740                 745                 750         


Gln Asn Ser Ser Arg Asn Thr Ala Arg Arg Arg Leu Arg Ser Glu Ser 
        755                 760                 765             


Ser Tyr Asp Ile Asp Asn Ile Val Ile Pro Met Ser Leu Val Ala Pro 
    770                 775                 780                 


Ala Lys Leu Glu Lys Leu Gln Tyr Lys Glu Ile Leu Thr Pro Ser Trp 
785                 790                 795                 800 


Arg Met Val Val Leu Gln Pro Leu Asp Glu Tyr Asn Leu Gly Lys Glu 
                805                 810                 815     


Glu Ile Glu Asp Leu Ser Asp Glu Val Phe Ser Leu Arg His Lys Lys 
            820                 825                 830         


Tyr Glu Glu Arg Glu Gln Ala Arg Trp Ser Leu Trp Glu Gln Ser Lys 
        835                 840                 845             


Trp His Arg Arg Asn Ser Arg Ala Tyr Ser Lys Asn Val Glu Gly Gln 
    850                 855                 860                 


Asp Leu Leu Leu Lys Glu Tyr Pro Asn Asn Phe Ser Ser Ser Gln Gln 
865                 870                 875                 880 


Cys Ala Ala Ala Ser Pro Pro Gly Leu Pro Ser Glu Asn Gln Asp Leu 
                885                 890                 895     


Cys Ala Tyr Gly Leu Pro Ser Leu Asn Gln Ser Gln Glu Thr Lys Ser 
            900                 905                 910         


Leu Trp Trp Glu Arg Arg Ala Phe Pro Leu Lys Gly Glu Asp Met Ala 
        915                 920                 925             


Ala Leu Leu Cys Gln Asp Glu Lys Lys Asp Gln Val Glu Arg Ser Ser 
    930                 935                 940                 


Thr Ala Phe His Gly Glu Ile Phe Gly Thr Ser Val Pro Glu Asn Gly 
945                 950                 955                 960 


His His Pro Lys Lys Gln Ser Asp Gly Met Glu Glu Tyr Lys Thr Phe 
                965                 970                 975     


Gly Leu Gly Leu Thr Asn Val Lys Lys Asn Arg 
            980                 985         


<210>  6074
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  6074

Met Ser Phe Ala Glu Ser Gly Trp Arg Ser Ala Leu Arg Arg Arg Gly 
1               5                   10                  15      


Pro Gly Thr Pro Gly Pro Val Ala Arg Pro Ser Tyr Ser Ser Phe Thr 
            20                  25                  30          


Gln Gly Asp Ser Trp Gly Glu Gly Glu Val Asp Glu Glu Glu Gly Cys 
        35                  40                  45              


Asp Gln Val Ala Arg Asp Leu Arg Ala Glu Phe Ser Ala Gly Ala Trp 
    50                  55                  60                  


Ser Glu Pro Arg Lys Arg Ser Val Leu Pro Pro Asp Gly Asn Gly Ser 
65                  70                  75                  80  


Pro Val Leu Pro Asp Lys Arg Asn Gly Ile Phe Pro Ala Ala Ala Gly 
                85                  90                  95      


Ser Arg Ala Gln Pro Arg Arg Trp Pro Val Gln Val Leu Ser Ile Leu 
            100                 105                 110         


Cys Ser Leu Leu Phe Ala Ile Leu Leu Ala Phe Leu Leu Ala Ile Ala 
        115                 120                 125             


Tyr Leu Ile Val Lys Glu Leu His Ala Glu Asn Leu Lys Asn Glu Asp 
    130                 135                 140                 


Asp Val Asp Thr Gly Leu Leu Gly Phe Trp Thr Leu Leu Ile Ile Ser 
145                 150                 155                 160 


Leu Thr Ala Gly Phe Ser Cys Cys Ser Phe Ser Trp Thr Val Thr Tyr 
                165                 170                 175     


Phe Asp Ser Phe Glu Pro Gly Met Phe Pro Pro Thr Pro Leu Ser Pro 
            180                 185                 190         


Ala Arg Phe Lys Lys Leu Thr Gly His Ser Phe His Met Gly Tyr Ser 
        195                 200                 205             


Met Ala Ile Leu Asn Gly Ile Val Ala Ala Leu Thr Val Ala Trp Cys 
    210                 215                 220                 


Leu Met 
225     


<210>  6075
<211>  510
<212>  PRT
<213>  Homo sapiens

<400>  6075

Met Tyr Thr Ser His Glu Asp Ile Gly Tyr Asp Phe Glu Asp Gly Pro 
1               5                   10                  15      


Lys Asp Lys Lys Thr Leu Lys Pro His Pro Asn Ile Asp Gly Gly Trp 
            20                  25                  30          


Ala Trp Met Met Val Leu Ser Ser Phe Phe Val His Ile Leu Ile Met 
        35                  40                  45              


Gly Ser Gln Met Ala Leu Gly Val Leu Asn Val Glu Trp Leu Glu Glu 
    50                  55                  60                  


Phe His Gln Ser Arg Gly Leu Thr Ala Trp Val Ser Ser Leu Ser Met 
65                  70                  75                  80  


Gly Ile Thr Leu Ile Val Gly Pro Phe Ile Gly Leu Phe Ile Asn Thr 
                85                  90                  95      


Cys Gly Cys Arg Gln Thr Ala Ile Ile Gly Gly Leu Val Asn Ser Leu 
            100                 105                 110         


Gly Trp Val Leu Ser Ala Tyr Ala Ala Asn Val His Tyr Leu Phe Ile 
        115                 120                 125             


Thr Phe Gly Val Ala Ala Gly Leu Gly Ser Gly Met Ala Tyr Leu Pro 
    130                 135                 140                 


Ala Val Val Met Val Gly Arg Tyr Phe Gln Lys Arg Arg Ala Leu Ala 
145                 150                 155                 160 


Gln Gly Leu Ser Thr Thr Gly Thr Gly Phe Gly Thr Phe Leu Met Thr 
                165                 170                 175     


Val Leu Leu Lys Tyr Leu Cys Ala Glu Tyr Gly Trp Arg Asn Ala Met 
            180                 185                 190         


Leu Ile Gln Gly Ala Val Ser Leu Asn Leu Cys Val Cys Gly Ala Leu 
        195                 200                 205             


Met Arg Pro Leu Ser Pro Gly Lys Asn Pro Asn Asp Pro Gly Glu Lys 
    210                 215                 220                 


Asp Val Arg Gly Leu Pro Ala His Ser Thr Glu Ser Val Lys Ser Thr 
225                 230                 235                 240 


Gly Gln Gln Gly Arg Thr Glu Glu Lys Asp Gly Gly Leu Gly Asn Glu 
                245                 250                 255     


Glu Thr Leu Cys Asp Leu Gln Ala Gln Glu Cys Pro Asp Gln Ala Gly 
            260                 265                 270         


His Arg Lys Asn Met Cys Ala Leu Arg Ile Leu Lys Thr Val Ser Trp 
        275                 280                 285             


Leu Thr Met Arg Val Arg Lys Gly Phe Glu Asp Trp Tyr Ser Gly Tyr 
    290                 295                 300                 


Phe Gly Thr Ala Ser Leu Phe Thr Asn Arg Met Phe Val Ala Phe Ile 
305                 310                 315                 320 


Phe Trp Ala Leu Phe Ala Tyr Ser Ser Phe Val Ile Pro Phe Ile His 
                325                 330                 335     


Leu Pro Glu Ile Val Asn Leu Tyr Asn Leu Ser Glu Gln Asn Asp Val 
            340                 345                 350         


Phe Pro Leu Thr Ser Ile Ile Ala Ile Val His Ile Phe Gly Lys Val 
        355                 360                 365             


Ile Leu Gly Val Ile Ala Asp Leu Pro Cys Ile Ser Val Trp Asn Val 
    370                 375                 380                 


Phe Leu Leu Ala Asn Phe Thr Leu Val Leu Ser Ile Phe Ile Leu Pro 
385                 390                 395                 400 


Leu Met His Thr Tyr Ala Gly Leu Ala Val Ile Cys Ala Leu Ile Gly 
                405                 410                 415     


Phe Ser Ser Gly Tyr Phe Ser Leu Met Pro Val Val Thr Glu Asp Leu 
            420                 425                 430         


Val Gly Ile Glu His Leu Ala Asn Ala Tyr Gly Ile Ile Ile Cys Ala 
        435                 440                 445             


Asn Gly Ile Ser Ala Leu Leu Gly Pro Pro Phe Ala Gly Trp Ile Tyr 
    450                 455                 460                 


Asp Ile Thr Gln Lys Tyr Asp Phe Ser Phe Tyr Ile Cys Gly Leu Leu 
465                 470                 475                 480 


Tyr Met Ile Gly Ile Leu Phe Leu Leu Ile Gln Pro Cys Ile Arg Ile 
                485                 490                 495     


Ile Glu Gln Ser Arg Arg Lys Tyr Met Asp Gly Ala His Val 
            500                 505                 510 


<210>  6076
<211>  870
<212>  PRT
<213>  Homo sapiens

<400>  6076

Met Asn Ser Asn Leu Pro Ala Glu Asn Leu Thr Ile Ala Val Asn Met 
1               5                   10                  15      


Thr Lys Thr Leu Pro Thr Ala Val Thr His Gly Phe Asn Ser Thr Asn 
            20                  25                  30          


Asp Pro Pro Ser Met Ser Ile Thr Arg Leu Phe Pro Ala Leu Leu Glu 
        35                  40                  45              


Cys Phe Gly Ile Val Leu Cys Gly Tyr Ile Ala Gly Arg Ala Asn Val 
    50                  55                  60                  


Ile Thr Ser Thr Gln Ala Lys Gly Leu Gly Asn Phe Val Ser Arg Phe 
65                  70                  75                  80  


Ala Leu Pro Ala Leu Leu Phe Lys Asn Met Val Val Leu Asn Phe Ser 
                85                  90                  95      


Asn Val Asp Trp Ser Phe Leu Tyr Ser Ile Leu Ile Ala Lys Ala Ser 
            100                 105                 110         


Val Phe Phe Ile Val Cys Val Leu Thr Leu Leu Val Ala Ser Pro Asp 
        115                 120                 125             


Ser Arg Phe Ser Lys Ala Gly Leu Phe Pro Ile Phe Ala Thr Gln Ser 
    130                 135                 140                 


Asn Asp Phe Ala Leu Gly Tyr Pro Ile Val Glu Ala Leu Tyr Gln Thr 
145                 150                 155                 160 


Thr Tyr Pro Glu Tyr Leu Gln Tyr Ile Tyr Leu Val Ala Pro Ile Ser 
                165                 170                 175     


Leu Met Met Leu Asn Pro Ile Gly Phe Ile Phe Cys Glu Ile Gln Lys 
            180                 185                 190         


Trp Lys Asp Thr Gln Asn Ala Ser Gln Asn Lys Ile Lys Ile Val Gly 
        195                 200                 205             


Leu Gly Leu Leu Arg Val Leu Gln Asn Pro Ile Val Phe Met Val Phe 
    210                 215                 220                 


Ile Gly Ile Ala Phe Asn Phe Ile Leu Asp Arg Lys Val Pro Val Tyr 
225                 230                 235                 240 


Val Glu Asn Phe Leu Asp Gly Leu Gly Asn Ser Phe Ser Gly Ser Ala 
                245                 250                 255     


Leu Phe Tyr Leu Gly Leu Thr Met Val Gly Lys Ile Lys Arg Leu Lys 
            260                 265                 270         


Lys Ser Ala Phe Val Val Leu Ile Leu Leu Ile Thr Ala Lys Leu Leu 
        275                 280                 285             


Val Leu Pro Leu Leu Cys Arg Glu Met Val Glu Leu Leu Asp Lys Gly 
    290                 295                 300                 


Asp Ser Val Val Asn His Thr Ser Leu Ser Asn Tyr Ala Phe Leu Tyr 
305                 310                 315                 320 


Gly Val Phe Pro Val Ala Pro Gly Val Ala Ile Phe Ala Thr Gln Phe 
                325                 330                 335     


Asn Met Glu Val Glu Ile Ile Thr Ser Gly Met Val Ile Ser Thr Phe 
            340                 345                 350         


Val Ser Ala Pro Ile Met Tyr Val Ser Ala Trp Leu Leu Thr Phe Pro 
        355                 360                 365             


Thr Met Asp Pro Lys Pro Leu Ala Tyr Ala Ile Gln Asn Val Ser Phe 
    370                 375                 380                 


Asp Ile Ser Ile Val Ser Leu Ile Ser Leu Ile Trp Ser Leu Ala Ile 
385                 390                 395                 400 


Leu Leu Leu Ser Lys Lys Tyr Lys Gln Leu Pro His Met Leu Thr Thr 
                405                 410                 415     


Asn Leu Leu Ile Ala Gln Ser Ile Val Cys Ala Gly Met Met Ile Trp 
            420                 425                 430         


Asn Phe Val Lys Glu Lys Asn Phe Val Gly Gln Ile Leu Val Phe Val 
        435                 440                 445             


Leu Leu Tyr Ser Ser Leu Tyr Ser Thr Tyr Leu Trp Thr Gly Leu Leu 
    450                 455                 460                 


Ala Ile Ser Leu Phe Leu Leu Lys Lys Arg Glu Arg Val Gln Ile Pro 
465                 470                 475                 480 


Val Gly Ile Ile Ile Ile Ser Gly Trp Gly Ile Pro Ala Leu Leu Val 
                485                 490                 495     


Gly Val Leu Leu Ile Thr Gly Lys His Asn Gly Asp Ser Ile Asp Ser 
            500                 505                 510         


Ala Phe Phe Tyr Gly Lys Glu Gln Met Ile Thr Thr Ala Val Thr Leu 
        515                 520                 525             


Phe Cys Ser Ile Leu Ile Ala Gly Ile Ser Leu Met Cys Met Asn Gln 
    530                 535                 540                 


Thr Ala Gln Ala Gly Ser Tyr Glu Gly Phe Asp Gln Ser Gln Ser His 
545                 550                 555                 560 


Lys Val Val Glu Pro Gly Asn Thr Ala Phe Glu Glu Ser Pro Ala Pro 
                565                 570                 575     


Val Asn Glu Pro Glu Leu Phe Thr Ser Ser Ile Pro Glu Thr Ser Cys 
            580                 585                 590         


Cys Ser Cys Ser Met Gly Asn Gly Glu Leu His Cys Pro Ser Ile Glu 
        595                 600                 605             


Pro Ile Ala Asn Thr Ser Thr Ser Glu Pro Val Ile Pro Ser Phe Glu 
    610                 615                 620                 


Lys Asn Asn His Cys Val Ser Arg Cys Asn Ser Gln Ser Cys Ile Leu 
625                 630                 635                 640 


Ala Gln Glu Glu Glu Gln Tyr Leu Gln Ser Gly Asp Gln Gln Leu Thr 
                645                 650                 655     


Arg His Val Leu Leu Cys Leu Leu Leu Ile Ile Gly Leu Phe Ala Asn 
            660                 665                 670         


Leu Ser Ser Cys Leu Trp Trp Leu Phe Asn Gln Glu Pro Gly Arg Leu 
        675                 680                 685             


Tyr Val Glu Leu Gln Phe Phe Cys Ala Val Phe Asn Phe Gly Gln Gly 
    690                 695                 700                 


Phe Ile Ser Phe Gly Ile Phe Gly Leu Asp Lys His Leu Ile Ile Leu 
705                 710                 715                 720 


Pro Phe Lys Arg Arg Leu Glu Phe Leu Trp Asn Asn Lys Asp Thr Ala 
                725                 730                 735     


Glu Asn Arg Asp Ser Pro Val Ser Glu Glu Ile Lys Met Thr Cys Gln 
            740                 745                 750         


Gln Phe Ile His Tyr His Arg Asp Leu Cys Ile Arg Asn Ile Val Lys 
        755                 760                 765             


Glu Arg Arg Cys Gly Ala Lys Thr Ser Ala Gly Thr Phe Cys Gly Cys 
    770                 775                 780                 


Asp Leu Val Ser Trp Leu Ile Glu Val Gly Leu Ala Ser Asp Arg Gly 
785                 790                 795                 800 


Glu Ala Val Ile Tyr Gly Asp Arg Leu Val Gln Gly Gly Val Ile Gln 
                805                 810                 815     


His Ile Thr Asn Glu Tyr Glu Phe Arg Asp Glu Tyr Leu Phe Tyr Arg 
            820                 825                 830         


Phe Leu Gln Lys Ser Pro Glu Gln Ser Pro Pro Ala Ile Asn Ala Asn 
        835                 840                 845             


Thr Leu Gln Gln Glu Arg Tyr Lys Glu Ile Glu His Ser Ser Pro Pro 
    850                 855                 860                 


Ser His Ser Pro Lys Thr 
865                 870 


<210>  6077
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  6077

Met Gly Leu Leu Arg Gly Gly Leu Pro Cys Ala Arg Ala Met Ala Arg 
1               5                   10                  15      


Leu Gly Ala Val Arg Ser His Tyr Cys Ala Leu Leu Leu Ala Ala Ala 
            20                  25                  30          


Leu Ala Val Cys Ala Phe Tyr Tyr Leu Gly Ser Gly Arg Glu Thr Phe 
        35                  40                  45              


Ser Ser Ala Thr Lys Arg Leu Lys Glu Ala Arg Ala Gly Ala Pro Ala 
    50                  55                  60                  


Ala Pro Ser Pro Pro Ala Leu Glu Leu Ala Arg Gly Ser Val Ala Pro 
65                  70                  75                  80  


Ala Pro Gly Ala Lys Ala Lys Ser Leu Glu Gly Gly Gly Ala Gly Pro 
                85                  90                  95      


Val Asp Tyr His Leu Leu Met Met Phe Thr Lys Ala Glu His Asn Ala 
            100                 105                 110         


Ala Leu Gln Ala Lys Ala Arg Val Ala Leu Arg Ser Leu Leu Arg Leu 
        115                 120                 125             


Ala Lys Phe Glu Ala His Glu Val Leu Asn Leu His Phe Val Ser Glu 
    130                 135                 140                 


Glu Ala Ser Arg Glu Val Ala Lys Gly Leu Leu Arg Glu Leu Leu Pro 
145                 150                 155                 160 


Pro Ala Ala Gly Phe Lys Cys Lys Val Ile Phe His Asp Val Ala Val 
                165                 170                 175     


Leu Thr Asp Lys Leu Phe Pro Ile Val Glu Ala Met Gln Lys His Phe 
            180                 185                 190         


Ser Ala Gly Leu Gly Thr Tyr Tyr Ser Asp Ser Ile Phe Phe Leu Ser 
        195                 200                 205             


Val Ala Met His Gln Ile Met Pro Lys Glu Ile Leu Gln Ile Ile Gln 
    210                 215                 220                 


Leu Asp Leu Asp Leu Lys Phe Lys Thr Asn Ile Arg Glu Leu Phe Glu 
225                 230                 235                 240 


Glu Phe Asp Ser Phe Leu Pro Gly Ala Ile Ile Gly Ile Ala Arg Glu 
                245                 250                 255     


Met Gln Pro Val Tyr Arg His Thr Phe Trp Gln Phe Arg His Glu Asn 
            260                 265                 270         


Pro Gln Thr Arg Val Gly Gly Pro Pro Pro Glu Gly Leu Pro Gly Phe 
        275                 280                 285             


Asn Ser Gly Val Met Leu Leu Asn Leu Glu Ala Met Arg Gln Ser Pro 
    290                 295                 300                 


Leu Tyr Ser Arg Leu Leu Glu Pro Ala Gln Val Gln Gln Leu Ala Asp 
305                 310                 315                 320 


Lys Tyr His Phe Arg Gly His Leu Gly Asp Gln Asp Phe Phe Thr Met 
                325                 330                 335     


Ile Gly Met Glu His Pro Lys Leu Phe His Val Leu Asp Cys Thr Trp 
            340                 345                 350         


Asn Arg Gln Leu Cys Thr Trp Trp Arg Asp His Gly Tyr Ser Asp Val 
        355                 360                 365             


Phe Glu Ala Tyr Phe Arg Cys Glu Gly His Val Lys Ile Tyr His Gly 
    370                 375                 380                 


Asn Cys Asn Thr Pro Ile Pro Glu Asp 
385                 390             


<210>  6078
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  6078

Met Ser Leu Val Glu Leu Leu Leu Trp Trp Asn Cys Phe Ser Arg Thr 
1               5                   10                  15      


Gly Val Ala Ala Ser Leu Glu Val Ser Glu Ser Pro Gly Ser Ile Gln 
            20                  25                  30          


Val Ala Arg Gly Gln Pro Ala Val Leu Pro Cys Thr Phe Thr Thr Ser 
        35                  40                  45              


Ala Ala Leu Ile Asn Leu Asn Val Ile Trp Met Val Thr Pro Leu Ser 
    50                  55                  60                  


Asn Ala Asn Gln Pro Glu Gln Val Ile Leu Tyr Gln Gly Gly Gln Met 
65                  70                  75                  80  


Phe Asp Gly Ala Pro Arg Phe His Gly Arg Val Gly Phe Thr Gly Thr 
                85                  90                  95      


Met Pro Ala Thr Asn Val Ser Ile Phe Ile Asn Asn Thr Gln Leu Ser 
            100                 105                 110         


Asp Thr Gly Thr Tyr Gln Cys Leu Val Asn Asn Leu Pro Asp Ile Gly 
        115                 120                 125             


Gly Arg Asn Ile Gly Val Thr Gly Leu Thr Val Leu Val Pro Pro Ser 
    130                 135                 140                 


Ala Pro His Cys Gln Ile Gln Gly Ser Gln Asp Ile Gly Ser Asp Val 
145                 150                 155                 160 


Ile Leu Leu Cys Ser Ser Glu Glu Gly Ile Pro Arg Pro Thr Tyr Leu 
                165                 170                 175     


Trp Glu Lys Leu Asp Asn Thr Leu Lys Leu Pro Pro Thr Ala Thr Gln 
            180                 185                 190         


Asp Gln Val Gln Gly Thr Val Thr Ile Arg Asn Ile Ser Ala Leu Ser 
        195                 200                 205             


Ser Gly Leu Tyr Gln Cys Val Ala Ser Asn Ala Ile Gly Thr Ser Thr 
    210                 215                 220                 


Cys Leu Leu Asp Leu Gln Val Ile Ser Pro Gln Pro Arg Asn Ile Gly 
225                 230                 235                 240 


Leu Ile Ala Gly Ala Ile Gly Thr Gly Ala Val Ile Ile Ile Phe Cys 
                245                 250                 255     


Ile Ala Leu Ile Leu Gly Ala Phe Phe Tyr Trp Arg Ser Lys Asn Lys 
            260                 265                 270         


Glu Glu Glu Glu Glu Glu Ile Pro Asn Glu Ile Arg Glu Asp Asp Leu 
        275                 280                 285             


Pro Pro Lys Cys Ser Ser Ala Lys Ala Phe His Thr Glu Ile Ser Ser 
    290                 295                 300                 


Ser Asp Asn Asn Thr Leu Thr Ser Ser Asn Ala Tyr Asn Ser Arg Tyr 
305                 310                 315                 320 


Trp Ser Asn Asn Pro Lys Val His Arg Asn Thr Glu Ser Val Ser His 
                325                 330                 335     


Phe Ser Asp Leu Gly Gln Ser Phe Ser Phe His Ser Gly Asn Ala Asn 
            340                 345                 350         


Ile Pro Ser Ile Tyr Ala Asn Gly Thr His Leu Val Pro Gly Gln His 
        355                 360                 365             


Lys Thr Leu Val Val Thr Ala Asn Arg Gly Ser Ser Pro Gln Val Met 
    370                 375                 380                 


Ser Arg Ser Asn Gly Ser Val Ser Arg Lys Pro Arg Pro Pro His Thr 
385                 390                 395                 400 


His Ser Tyr Thr Ile Ser His Ala Thr Leu Glu Arg Ile Gly Ala Val 
                405                 410                 415     


Pro Val Met Val Pro Ala Gln Ser Arg Ala Gly Ser Leu Val 
            420                 425                 430 


<210>  6079
<211>  535
<212>  PRT
<213>  Homo sapiens

<400>  6079

Met Val Asp Leu Ser Val Ser Pro Asp Ser Leu Lys Pro Val Ser Leu 
1               5                   10                  15      


Thr Ser Ser Leu Val Phe Leu Met His Leu Leu Leu Leu Gln Pro Gly 
            20                  25                  30          


Glu Pro Ser Ser Glu Val Lys Val Leu Gly Pro Glu Tyr Pro Ile Leu 
        35                  40                  45              


Ala Leu Val Gly Glu Glu Val Glu Phe Pro Cys His Leu Trp Pro Gln 
    50                  55                  60                  


Leu Asp Ala Gln Gln Met Glu Ile Arg Trp Phe Arg Ser Gln Thr Phe 
65                  70                  75                  80  


Asn Val Val His Leu Tyr Gln Glu Gln Gln Glu Leu Pro Gly Arg Gln 
                85                  90                  95      


Met Pro Ala Phe Arg Asn Arg Thr Lys Leu Val Lys Asp Asp Ile Ala 
            100                 105                 110         


Tyr Gly Ser Val Val Leu Gln Leu His Ser Ile Ile Pro Ser Asp Lys 
        115                 120                 125             


Gly Thr Tyr Gly Cys Arg Phe His Ser Asp Asn Phe Ser Gly Glu Ala 
    130                 135                 140                 


Leu Trp Glu Leu Glu Val Ala Gly Leu Gly Ser Asp Pro His Leu Ser 
145                 150                 155                 160 


Leu Glu Gly Phe Lys Glu Gly Gly Ile Gln Leu Arg Leu Arg Ser Ser 
                165                 170                 175     


Gly Trp Tyr Pro Lys Pro Lys Val Gln Trp Arg Asp His Gln Gly Gln 
            180                 185                 190         


Cys Leu Pro Pro Glu Phe Glu Ala Ile Val Trp Asp Ala Gln Asp Leu 
        195                 200                 205             


Phe Ser Leu Glu Thr Ser Val Val Val Arg Ala Gly Ala Leu Ser Asn 
    210                 215                 220                 


Val Ser Val Ser Ile Gln Asn Leu Leu Leu Ser Gln Lys Lys Glu Leu 
225                 230                 235                 240 


Val Val Gln Ile Ala Asp Val Phe Val Pro Gly Ala Ser Ala Trp Lys 
                245                 250                 255     


Ser Ala Phe Val Ala Thr Leu Pro Leu Leu Leu Val Leu Ala Ala Leu 
            260                 265                 270         


Ala Leu Gly Val Leu Arg Lys Gln Arg Arg Ser Arg Glu Lys Leu Arg 
        275                 280                 285             


Lys Gln Ala Glu Lys Arg Gln Glu Lys Leu Thr Ala Glu Leu Glu Lys 
    290                 295                 300                 


Leu Gln Thr Glu Leu Asp Trp Arg Arg Ala Glu Gly Gln Ala Glu Trp 
305                 310                 315                 320 


Arg Ala Ala Gln Lys Tyr Ala Val Asp Val Thr Leu Asp Pro Ala Ser 
                325                 330                 335     


Ala His Pro Ser Leu Glu Val Ser Glu Asp Gly Lys Ser Val Ser Ser 
            340                 345                 350         


Arg Gly Ala Pro Pro Gly Pro Ala Pro Gly His Pro Gln Arg Phe Ser 
        355                 360                 365             


Glu Gln Thr Cys Ala Leu Ser Leu Glu Arg Phe Ser Ala Gly Arg His 
    370                 375                 380                 


Tyr Trp Glu Val His Val Gly Arg Arg Ser Arg Trp Phe Leu Gly Ala 
385                 390                 395                 400 


Cys Leu Ala Ala Val Pro Arg Ala Gly Pro Ala Arg Leu Ser Pro Ala 
                405                 410                 415     


Ala Gly Tyr Trp Val Leu Gly Leu Trp Asn Gly Cys Glu Tyr Phe Val 
            420                 425                 430         


Leu Ala Pro His Arg Val Ala Leu Thr Leu Arg Val Pro Pro Arg Arg 
        435                 440                 445             


Leu Gly Val Phe Leu Asp Tyr Glu Ala Gly Glu Leu Ser Phe Phe Asn 
    450                 455                 460                 


Val Ser Asp Gly Ser His Ile Phe Thr Phe His Asp Thr Phe Ser Gly 
465                 470                 475                 480 


Ala Leu Cys Ala Tyr Phe Arg Pro Arg Ala His Asp Gly Gly Glu His 
                485                 490                 495     


Pro Asp Pro Leu Thr Ile Cys Pro Leu Pro Val Arg Gly Thr Gly Val 
            500                 505                 510         


Pro Glu Glu Asn Asp Ser Asp Thr Trp Leu Gln Pro Tyr Glu Pro Ala 
        515                 520                 525             


Asp Pro Ala Leu Asp Trp Trp 
    530                 535 


<210>  6080
<211>  446
<212>  PRT
<213>  Homo sapiens

<400>  6080

Met Glu Lys Asp Lys His Ser His Phe Tyr Asn Gln Lys Ser Asp Phe 
1               5                   10                  15      


Arg Ile Glu His Ser Met Leu Glu Glu Leu Glu Asn Lys Leu Ile His 
            20                  25                  30          


Ser Arg Lys Thr Glu Arg Ala Lys Ile Gln Gln Gln Leu Ala Lys Ile 
        35                  40                  45              


His Asn Asn Val Lys Lys Leu Gln His Gln Leu Lys Asp Val Lys Pro 
    50                  55                  60                  


Thr Pro Asp Phe Val Glu Lys Leu Arg Glu Met Met Glu Glu Ile Glu 
65                  70                  75                  80  


Asn Ala Ile Asn Thr Phe Lys Glu Glu Gln Arg Leu Ile Tyr Glu Glu 
                85                  90                  95      


Leu Ile Lys Glu Glu Lys Thr Thr Asn Asn Glu Leu Ser Ala Ile Ser 
            100                 105                 110         


Arg Lys Ile Asp Thr Trp Ala Leu Gly Asn Ser Glu Thr Glu Lys Ala 
        115                 120                 125             


Phe Arg Ala Ile Ser Ser Lys Val Pro Val Asp Lys Val Thr Pro Ser 
    130                 135                 140                 


Thr Leu Pro Glu Glu Val Leu Asp Phe Glu Lys Phe Leu Gln Gln Thr 
145                 150                 155                 160 


Gly Gly Arg Gln Gly Ala Trp Asp Asp Tyr Asp His Gln Asn Phe Val 
                165                 170                 175     


Lys Val Arg Asn Lys His Lys Gly Lys Pro Thr Phe Met Glu Glu Val 
            180                 185                 190         


Leu Glu His Leu Pro Gly Lys Thr Gln Asp Glu Val Gln Gln His Glu 
        195                 200                 205             


Lys Trp Tyr Gln Lys Phe Leu Ala Leu Glu Glu Arg Lys Lys Glu Ser 
    210                 215                 220                 


Ile Gln Ile Trp Lys Thr Lys Lys Gln Gln Lys Arg Glu Glu Ile Phe 
225                 230                 235                 240 


Lys Leu Lys Glu Lys Ala Asp Asn Thr Pro Val Leu Phe His Asn Lys 
                245                 250                 255     


Gln Glu Asp Asn Gln Lys Gln Lys Glu Glu Gln Arg Lys Lys Gln Lys 
            260                 265                 270         


Leu Ala Val Glu Ala Trp Lys Lys Gln Lys Ser Ile Glu Met Ser Met 
        275                 280                 285             


Lys Cys Ala Ser Gln Leu Lys Glu Glu Glu Glu Lys Glu Lys Lys His 
    290                 295                 300                 


Gln Lys Glu Arg Gln Arg Gln Phe Lys Leu Lys Leu Leu Leu Glu Ser 
305                 310                 315                 320 


Tyr Thr Gln Gln Lys Lys Glu Gln Glu Glu Phe Leu Arg Leu Glu Lys 
                325                 330                 335     


Glu Ile Arg Glu Lys Ala Glu Lys Ala Glu Lys Arg Lys Asn Ala Ala 
            340                 345                 350         


Asp Glu Ile Ser Arg Phe Gln Glu Arg Asp Leu His Lys Leu Glu Leu 
        355                 360                 365             


Lys Ile Leu Asp Arg Gln Ala Lys Glu Asp Glu Lys Ser Gln Lys Gln 
    370                 375                 380                 


Arg Arg Leu Ala Lys Leu Lys Glu Lys Val Glu Asn Asn Val Ser Arg 
385                 390                 395                 400 


Asp Pro Ser Arg Leu Tyr Lys Pro Thr Lys Gly Trp Glu Glu Arg Thr 
                405                 410                 415     


Lys Lys Ile Gly Pro Thr Gly Ser Gly Pro Leu Leu His Ile Pro His 
            420                 425                 430         


Arg Ala Ile Pro Thr Trp Arg Gln Gly Ile Gln Arg Arg Val 
        435                 440                 445     


<210>  6081
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  6081

Met Lys Val Gln Leu Gly Gln Val Glu Ile Lys Cys Pro Ile Thr Glu 
1               5                   10                  15      


Cys Phe Glu Phe Leu Glu Glu Thr Thr Val Val Tyr Asn Leu Thr His 
            20                  25                  30          


Glu Asp Ser Ile Lys Tyr Lys Tyr Phe Leu Glu Leu Gly Arg Ile Asp 
        35                  40                  45              


Ser Ser Thr Lys Pro Cys Pro Gln Cys Lys His Phe Thr Thr Phe Lys 
    50                  55                  60                  


Lys Lys Gly His Ile Pro Thr Pro Ser Arg Ser Glu Ser Lys Tyr Lys 
65                  70                  75                  80  


Ile Gln Cys Pro Thr Cys Gln Phe Val Trp Cys Phe Lys Cys His Ser 
                85                  90                  95      


Pro Trp His Glu Gly Val Asn Cys Lys Glu Tyr Lys Lys Gly Asp Lys 
            100                 105                 110         


Leu Leu Arg His Trp Ala Ser Glu Ile Glu His Gly Gln Arg Asn Ala 
        115                 120                 125             


Gln Lys Cys Pro Lys Cys Lys Ile His Ile Gln Arg Thr Glu Gly Cys 
    130                 135                 140                 


Asp His Met Thr Cys Ser Gln Cys Asn Thr Asn Phe Cys Tyr Arg Cys 
145                 150                 155                 160 


Gly Glu Arg Tyr Arg Gln Leu Arg Phe Phe Gly Asp His Thr Ser Asn 
                165                 170                 175     


Leu Ser Ile Phe Gly Cys Lys Tyr Arg Tyr Leu Pro Glu Arg Pro His 
            180                 185                 190         


Leu Arg Arg Leu Val Arg Gly Ser Val Cys Ala Gly Lys Leu Phe Ile 
        195                 200                 205             


Ala Pro Leu Ile Met Val Leu Gly Leu Ala Leu Gly Ala Ile Ala Val 
    210                 215                 220                 


Val Ile Val Glu Glu Ile Lys Thr Tyr Trp Asn Leu Ile Ser Gly Arg 
225                 230                 235                 240 


Thr Arg Asn Gln Thr Gln His Leu Ala Pro Gln Pro Val Leu Leu Ser 
                245                 250                 255     


Asp Met Leu Tyr Cys Leu Lys Gln Val Phe Ile Cys Ile Ser Tyr Leu 
            260                 265                 270         


Leu Pro Leu 
        275 


<210>  6082
<211>  606
<212>  PRT
<213>  Homo sapiens

<400>  6082

Met Leu His Thr Ala Ile Ser Cys Trp Gln Pro Phe Leu Gly Leu Ala 
1               5                   10                  15      


Val Val Leu Ile Phe Met Gly Ser Thr Ile Gly Cys Pro Ala Arg Cys 
            20                  25                  30          


Glu Cys Ser Ala Gln Asn Lys Ser Val Ser Cys His Arg Arg Arg Leu 
        35                  40                  45              


Ile Ala Ile Pro Glu Gly Ile Pro Ile Glu Thr Lys Ile Leu Asp Leu 
    50                  55                  60                  


Ser Lys Asn Arg Leu Lys Ser Val Asn Pro Glu Glu Phe Ile Ser Tyr 
65                  70                  75                  80  


Pro Leu Leu Glu Glu Ile Asp Leu Ser Asp Asn Ile Ile Ala Asn Val 
                85                  90                  95      


Glu Pro Gly Ala Phe Asn Asn Leu Phe Asn Leu Arg Ser Leu Arg Leu 
            100                 105                 110         


Lys Gly Asn Arg Leu Lys Leu Val Pro Leu Gly Val Phe Thr Gly Leu 
        115                 120                 125             


Ser Asn Leu Thr Lys Leu Asp Ile Ser Glu Asn Lys Ile Val Ile Leu 
    130                 135                 140                 


Leu Asp Tyr Met Phe Gln Asp Leu His Asn Leu Lys Ser Leu Glu Val 
145                 150                 155                 160 


Gly Asp Asn Asp Leu Val Tyr Ile Ser His Arg Ala Phe Ser Gly Leu 
                165                 170                 175     


Leu Ser Leu Glu Gln Leu Thr Leu Glu Lys Cys Asn Leu Thr Ala Val 
            180                 185                 190         


Pro Thr Glu Ala Leu Ser His Leu Arg Ser Leu Ile Ser Leu His Leu 
        195                 200                 205             


Lys His Leu Asn Ile Asn Asn Met Pro Val Tyr Ala Phe Lys Arg Leu 
    210                 215                 220                 


Phe His Leu Lys His Leu Glu Ile Asp Tyr Trp Pro Leu Leu Asp Met 
225                 230                 235                 240 


Met Pro Ala Asn Ser Leu Tyr Gly Leu Asn Leu Thr Ser Leu Ser Val 
                245                 250                 255     


Thr Asn Thr Asn Leu Ser Thr Val Pro Phe Leu Ala Phe Lys His Leu 
            260                 265                 270         


Val Tyr Leu Thr His Leu Asn Leu Ser Tyr Asn Pro Ile Ser Thr Ile 
        275                 280                 285             


Glu Ala Gly Met Phe Ser Asp Leu Ile Arg Leu Gln Glu Leu His Ile 
    290                 295                 300                 


Val Gly Ala Gln Leu Arg Thr Ile Glu Pro His Ser Phe Gln Gly Leu 
305                 310                 315                 320 


Arg Phe Leu Arg Val Leu Asn Val Ser Gln Asn Leu Leu Glu Thr Leu 
                325                 330                 335     


Glu Glu Asn Val Phe Ser Ser Pro Arg Ala Leu Glu Val Leu Ser Ile 
            340                 345                 350         


Asn Asn Asn Pro Leu Ala Cys Asp Cys Arg Leu Leu Trp Ile Leu Gln 
        355                 360                 365             


Arg Gln Pro Thr Leu Gln Phe Gly Gly Gln Gln Pro Met Cys Ala Gly 
    370                 375                 380                 


Pro Asp Thr Ile Arg Glu Arg Ser Phe Lys Asp Phe His Ser Thr Ala 
385                 390                 395                 400 


Leu Ser Phe Tyr Phe Thr Cys Lys Lys Pro Lys Ile Arg Glu Lys Lys 
                405                 410                 415     


Leu Gln His Leu Leu Val Asp Glu Gly Gln Thr Val Gln Leu Glu Cys 
            420                 425                 430         


Ser Ala Asp Gly Asp Pro Gln Pro Val Ile Ser Trp Val Thr Pro Arg 
        435                 440                 445             


Arg Arg Phe Ile Thr Thr Lys Ser Asn Gly Arg Ala Thr Val Leu Gly 
    450                 455                 460                 


Asp Gly Thr Leu Glu Ile Arg Phe Ala Gln Asp Gln Asp Ser Gly Met 
465                 470                 475                 480 


Tyr Val Cys Ile Ala Ser Asn Ala Ala Gly Asn Asp Thr Phe Thr Ala 
                485                 490                 495     


Ser Leu Thr Val Lys Gly Phe Ala Ser Asp Arg Phe Leu Tyr Ala Asn 
            500                 505                 510         


Arg Thr Pro Met Tyr Met Thr Asp Ser Asn Asp Thr Ile Ser Asn Gly 
        515                 520                 525             


Thr Asn Ala Asn Thr Phe Ser Leu Asp Leu Lys Thr Ile Leu Val Ser 
    530                 535                 540                 


Thr Ala Met Gly Cys Phe Thr Phe Leu Gly Val Val Leu Phe Cys Phe 
545                 550                 555                 560 


Leu Leu Leu Phe Val Trp Ser Arg Gly Lys Gly Lys His Lys Asn Ser 
                565                 570                 575     


Ile Asp Leu Glu Tyr Val Pro Arg Lys Asn Asn Gly Ala Val Val Glu 
            580                 585                 590         


Gly Glu Val Ala Gly Pro Arg Arg Phe Asn Met Lys Met Ile 
        595                 600                 605     


<210>  6083
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  6083

Met Ser Ser His Arg Arg Lys Ala Lys Gly Arg Asn Arg Arg Ser His 
1               5                   10                  15      


Arg Ala Met Arg Val Ala His Leu Glu Leu Ala Thr Tyr Glu Leu Ala 
            20                  25                  30          


Ala Thr Glu Ser Asn Pro Glu Ser Ser His Pro Gly Tyr Glu Ala Ala 
        35                  40                  45              


Met Ala Asp Arg Pro Gln Pro Gly Trp Arg Glu Ser Leu Lys Met Arg 
    50                  55                  60                  


Val Ser Lys Pro Phe Gly Met Leu Met Leu Ser Ile Trp Ile Leu Leu 
65                  70                  75                  80  


Phe Val Cys Tyr Tyr Leu Ser Tyr Tyr Leu Cys Ser Gly Ser Ser Tyr 
                85                  90                  95      


Phe Val Leu Ala Asn Gly His Ile Leu Pro Asn Ser Glu Asn Ala His 
            100                 105                 110         


Gly Gln Ser Leu Glu Glu Asp Ser Ala Leu Glu Ala Leu Leu Asn Phe 
        115                 120                 125             


Phe Phe Pro Thr Thr Cys Asn Leu Arg Glu Asn Gln Val Ala Lys Pro 
    130                 135                 140                 


Cys Asn Glu Leu Gln Asp Leu Ser Glu Ser Glu Cys Leu Arg His Lys 
145                 150                 155                 160 


Cys Cys Phe Ser Ser Ser Gly Thr Thr Ser Phe Lys Cys Phe Ala Pro 
                165                 170                 175     


Phe Arg Asp Val Pro Lys Gln Met Met Gln Met Phe Gly Leu Gly Ala 
            180                 185                 190         


Ile Ser Leu Ile Leu Val Cys Leu Pro Ile Tyr Cys Arg Ser Leu Phe 
        195                 200                 205             


Trp Arg Ser Glu Pro Ala Asp Asp Leu Gln Arg Gln Asp Asn Arg Val 
    210                 215                 220                 


Val Thr Gly Leu Lys Lys Gln Arg Arg Lys Arg Lys Arg Lys Ser Glu 
225                 230                 235                 240 


Met Leu Gln Lys Ala Ala Arg Gly Arg Glu Glu His Gly Asp Glu 
                245                 250                 255 


<210>  6084
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  6084

Met Ala Glu Asn His Ala Gln Asn Lys Ala Lys Leu Ile Ser Glu Thr 
1               5                   10                  15      


Arg Arg Arg Phe Glu Ala Glu Tyr Val Thr Asp Lys Ser Asp Lys Tyr 
            20                  25                  30          


Asp Ala Arg Asp Val Glu Arg Leu Gln Gln Asp Asp Asn Trp Val Glu 
        35                  40                  45              


Ser Tyr Leu Ser Trp Arg His Asn Ile Val Asp Glu Thr Leu Lys Met 
    50                  55                  60                  


Leu Asp Glu Ser Phe Gln Trp Arg Lys Glu Ile Ser Val Asn Asp Leu 
65                  70                  75                  80  


Asn Glu Ser Ser Ile Pro Arg Trp Leu Leu Glu Ile Gly Val Ile Tyr 
                85                  90                  95      


Leu His Gly Tyr Asp Lys Glu Gly Asn Lys Leu Phe Trp Ile Arg Val 
            100                 105                 110         


Lys Tyr His Val Lys Asp Gln Lys Thr Ile Leu Asp Lys Lys Lys Leu 
        115                 120                 125             


Ile Ala Phe Trp Leu Glu Arg Tyr Ala Lys Arg Glu Asn Gly Lys Pro 
    130                 135                 140                 


Val Thr Val Met Phe Asp Leu Ser Glu Thr Gly Ile Asn Ser Ile Asp 
145                 150                 155                 160 


Met Asp Phe Val Arg Phe Ile Ile Asn Cys Phe Lys Val Tyr Tyr Pro 
                165                 170                 175     


Lys Tyr Leu Ser Lys Ile Val Ile Phe Asp Met Pro Trp Leu Met Asn 
            180                 185                 190         


Ala Ala Phe Lys Ile Val Lys Thr Trp Leu Gly Pro Glu Ala Val Ser 
        195                 200                 205             


Leu Leu Lys Phe Thr Ser Lys Asn Glu Val Gln Asp Tyr Val Ser Val 
    210                 215                 220                 


Glu Tyr Leu Pro Pro His Met Gly Gly Thr Asp Pro Phe Lys Tyr Ser 
225                 230                 235                 240 


Tyr Pro Pro Leu Val Asp Asp Asp Phe Gln Thr Pro Leu Cys Glu Asn 
                245                 250                 255     


Gly Pro Ile Thr Ser Glu Asp Glu Thr Ser Ser Lys Glu Asp Ile Glu 
            260                 265                 270         


Ser Asp Gly Lys Glu Thr Leu Glu Thr Ile Ser Asn Glu Glu Gln Thr 
        275                 280                 285             


Pro Leu Leu Lys Lys Ile Asn Pro Thr Glu Ser Thr Ser Lys Ala Glu 
    290                 295                 300                 


Glu Asn Glu Lys Val Asp Ser Lys Val Lys Ala Phe Lys Lys Pro Leu 
305                 310                 315                 320 


Ser Val Phe Lys Gly Pro Leu Leu His Ile Ser Pro Ala Glu Glu Leu 
                325                 330                 335     


Tyr Phe Gly Ser Thr Glu Ser Gly Glu Lys Lys Thr Leu Ile Val Leu 
            340                 345                 350         


Thr Asn Val Thr Lys Asn Ile Val Ala Phe Lys Val Arg Thr Thr Ala 
        355                 360                 365             


Pro Glu Lys Tyr Arg Val Lys Pro Ser Asn Ser Ser Cys Asp Pro Gly 
    370                 375                 380                 


Ala Ser Val Asp Ile Val Val Ser Pro His Gly Gly Leu Thr Val Ser 
385                 390                 395                 400 


Ala Gln Asp Arg Phe Leu Ile Met Ala Ala Glu Met Glu Gln Ser Ser 
                405                 410                 415     


Gly Thr Gly Pro Ala Glu Leu Thr Gln Phe Trp Lys Glu Val Pro Arg 
            420                 425                 430         


Asn Lys Val Met Glu His Arg Leu Arg Cys His Thr Val Glu Ser Ser 
        435                 440                 445             


Lys Pro Asn Thr Leu Thr Leu Lys Asp Asn Ala Phe Asn Met Ser Asp 
    450                 455                 460                 


Lys Thr Ser Glu Asp Ile Cys Leu Gln Leu Ser Arg Leu Leu Glu Ser 
465                 470                 475                 480 


Asn Arg Lys Leu Glu Asp Gln Val Gln Arg Cys Ile Trp Phe Gln Gln 
                485                 490                 495     


Leu Leu Leu Ser Leu Thr Met Leu Leu Leu Ala Phe Val Thr Ser Phe 
            500                 505                 510         


Phe Tyr Leu Leu Tyr Ser 
        515             


<210>  6085
<211>  836
<212>  PRT
<213>  Homo sapiens

<400>  6085

Met Ile Ala Glu Leu Val Ser Ser Ala Leu Gly Leu Ala Leu Tyr Leu 
1               5                   10                  15      


Asn Thr Leu Ser Ala Asp Phe Cys Tyr Asp Asp Ser Arg Ala Ile Lys 
            20                  25                  30          


Thr Asn Gln Asp Leu Leu Pro Glu Thr Pro Trp Thr His Ile Phe Tyr 
        35                  40                  45              


Asn Asp Phe Trp Gly Thr Leu Leu Thr His Ser Gly Ser His Lys Ser 
    50                  55                  60                  


Tyr Arg Pro Leu Cys Thr Leu Ser Phe Arg Leu Asn His Ala Ile Gly 
65                  70                  75                  80  


Gly Leu Asn Pro Trp Ser Tyr His Leu Val Asn Val Leu Leu His Ala 
                85                  90                  95      


Ala Val Thr Gly Leu Phe Thr Ser Phe Ser Lys Ile Leu Leu Gly Asp 
            100                 105                 110         


Gly Tyr Trp Thr Phe Met Ala Gly Leu Met Phe Ala Ser His Pro Ile 
        115                 120                 125             


His Thr Glu Ala Val Ala Gly Ile Val Gly Arg Ala Asp Val Gly Ala 
    130                 135                 140                 


Ser Leu Phe Phe Leu Leu Ser Leu Leu Cys Tyr Ile Lys His Cys Ser 
145                 150                 155                 160 


Thr Arg Gly Tyr Ser Ala Arg Thr Trp Gly Trp Phe Leu Gly Ser Gly 
                165                 170                 175     


Leu Cys Ala Gly Cys Ser Met Leu Trp Lys Glu Gln Gly Val Thr Val 
            180                 185                 190         


Leu Ala Val Ser Ala Val Tyr Asp Val Phe Val Phe His Arg Leu Lys 
        195                 200                 205             


Ile Lys Gln Ile Leu Pro Thr Ile Tyr Lys Arg Lys Asn Leu Ser Leu 
    210                 215                 220                 


Phe Leu Ser Ile Ser Leu Leu Ile Phe Trp Gly Ser Ser Leu Leu Gly 
225                 230                 235                 240 


Ala Arg Leu Tyr Trp Met Gly Asn Lys Pro Pro Ser Phe Ser Asn Ser 
                245                 250                 255     


Asp Asn Pro Ala Ala Asp Ser Asp Ser Leu Leu Thr Arg Thr Leu Thr 
            260                 265                 270         


Phe Phe Tyr Leu Pro Thr Lys Asn Leu Trp Leu Leu Leu Cys Pro Asp 
        275                 280                 285             


Thr Leu Ser Phe Asp Trp Ser Met Asp Ala Val Pro Leu Leu Lys Thr 
    290                 295                 300                 


Val Cys Asp Trp Arg Asn Leu His Thr Val Ala Phe Tyr Thr Gly Leu 
305                 310                 315                 320 


Leu Leu Leu Ala Tyr Tyr Gly Leu Lys Ser Pro Ser Val Asp Arg Glu 
                325                 330                 335     


Cys Asn Gly Lys Thr Val Thr Asn Gly Lys Gln Asn Ala Asn Gly His 
            340                 345                 350         


Ser Cys Leu Ser Asp Val Glu Tyr Gln Asn Ser Glu Thr Lys Ser Ser 
        355                 360                 365             


Phe Ala Ser Lys Val Glu Asn Gly Ile Lys Asn Asp Val Ser Gln Arg 
    370                 375                 380                 


Thr Gln Leu Pro Ser Thr Glu Asn Ile Val Val Leu Ser Leu Ser Leu 
385                 390                 395                 400 


Leu Ile Ile Pro Phe Val Pro Ala Thr Asn Leu Phe Phe Tyr Val Gly 
                405                 410                 415     


Phe Val Ile Ala Glu Arg Val Leu Tyr Ile Pro Ser Met Gly Phe Cys 
            420                 425                 430         


Leu Leu Ile Thr Val Gly Ala Arg Ala Leu Tyr Val Lys Val Gln Lys 
        435                 440                 445             


Arg Phe Leu Lys Ser Leu Ile Phe Tyr Ala Thr Ala Thr Leu Ile Val 
    450                 455                 460                 


Phe Tyr Gly Leu Lys Thr Ala Ile Arg Asn Gly Asp Trp Gln Asn Glu 
465                 470                 475                 480 


Glu Met Leu Tyr Arg Ser Gly Ile Lys Val Asn Pro Ala Lys Ala Trp 
                485                 490                 495     


Gly Asn Leu Gly Asn Val Leu Lys Ser Gln Ser Lys Ile Ser Glu Ala 
            500                 505                 510         


Glu Ser Ala Tyr Arg Asn Ala Leu Tyr Tyr Arg Ser Asn Met Ala Asp 
        515                 520                 525             


Met Leu Tyr Asn Leu Gly Leu Leu Leu Gln Glu Asn Ser Arg Phe Ala 
    530                 535                 540                 


Glu Ala Leu His Tyr Tyr Lys Leu Ala Ile Gly Ser Arg Pro Thr Leu 
545                 550                 555                 560 


Ala Ser Ala Tyr Leu Asn Thr Gly Ile Ile Leu Met Asn Gln Gly Arg 
                565                 570                 575     


Thr Glu Glu Ala Arg Arg Thr Phe Leu Lys Cys Ser Glu Ile Pro Asp 
            580                 585                 590         


Glu Asn Leu Lys Asp Pro His Ala His Lys Ser Ser Val Thr Ser Cys 
        595                 600                 605             


Leu Tyr Asn Leu Gly Lys Leu Tyr His Glu Gln Gly His Tyr Glu Glu 
    610                 615                 620                 


Ala Leu Ser Val Tyr Lys Glu Ala Ile Gln Lys Met Pro Arg Gln Phe 
625                 630                 635                 640 


Ala Pro Gln Ser Leu Tyr Asn Met Met Gly Glu Ala Tyr Met Arg Leu 
                645                 650                 655     


Ser Lys Leu Pro Glu Ala Glu His Trp Tyr Met Glu Ser Leu Arg Ser 
            660                 665                 670         


Lys Thr Asp His Ile Pro Ala His Leu Thr Tyr Gly Lys Leu Leu Ala 
        675                 680                 685             


Leu Thr Gly Arg Lys Ser Glu Ala Glu Lys Leu Phe Leu Lys Ala Ile 
    690                 695                 700                 


Glu Leu Asp Pro Thr Lys Gly Asn Cys Tyr Met His Tyr Gly Gln Phe 
705                 710                 715                 720 


Leu Leu Glu Glu Ala Arg Leu Ile Glu Ala Ala Glu Met Ala Lys Lys 
                725                 730                 735     


Ala Ala Glu Leu Asp Ser Thr Glu Phe Asp Val Val Phe Asn Ala Ala 
            740                 745                 750         


His Met Leu Arg Gln Ala Ser Leu Asn Glu Ala Ala Glu Lys Tyr Tyr 
        755                 760                 765             


Asp Leu Ala Ala Arg Leu Arg Pro Asn Tyr Pro Ala Ala Leu Met Asn 
    770                 775                 780                 


Leu Gly Ala Ile Leu His Leu Asn Gly Arg Leu Gln Lys Ala Glu Ala 
785                 790                 795                 800 


Asn Tyr Leu Arg Ala Leu Gln Leu Lys Pro Asp Asp Val Ile Thr Gln 
                805                 810                 815     


Ser Asn Leu Arg Lys Leu Trp Asn Ile Met Glu Lys Gln Gly Leu Lys 
            820                 825                 830         


Thr Ser Lys Thr 
        835     


<210>  6086
<211>  975
<212>  PRT
<213>  Homo sapiens

<400>  6086

Met Thr Gln Gln Pro Gln Asp Asp Phe Asp Arg Ser Val Glu Asp Ala 
1               5                   10                  15      


Gln Ala Trp Met Lys Ala Val Gln Asp Gln Leu Gln Val Asn Asp Asn 
            20                  25                  30          


Thr Gln Gly Pro Arg Ala Ala Leu Glu Ala Arg Leu Trp Glu Thr Glu 
        35                  40                  45              


Lys Ile Cys Gln Leu Glu Pro Glu Gly Arg Val Arg Val Asp Leu Val 
    50                  55                  60                  


Leu Arg Met Ala Glu Ala Leu Leu Ala Cys Cys Pro Gly Asp Gln Lys 
65                  70                  75                  80  


Pro Gly Ile Leu Ala Arg Leu Lys Asp Ile Lys Ala Gln Trp Glu Glu 
                85                  90                  95      


Thr Val Thr Tyr Met Thr His Cys His Ser Arg Ile Glu Trp Val Trp 
            100                 105                 110         


Leu His Trp Ser Glu Tyr Leu Leu Ala Arg Asp Glu Phe Tyr Arg Trp 
        115                 120                 125             


Phe Gln Lys Met Met Val Thr Leu Glu Pro His Ile Glu Leu Gln Leu 
    130                 135                 140                 


Gly Leu Lys Glu Lys Gln Trp Gln Leu Ser His Ala Gln Val Leu Leu 
145                 150                 155                 160 


His Asn Val Asp Asn Gln Ala Val Leu Leu Asp Arg Leu Leu Glu Glu 
                165                 170                 175     


Ala Ala Ser Leu Phe Asn Arg Ile Gly Asp Pro Ser Val Asp Glu Asp 
            180                 185                 190         


Ala Gln Lys Arg Met Lys Ala Glu Tyr Asp Ala Val Lys Ala Lys Ala 
        195                 200                 205             


Gln Lys Arg Val Asp Leu Leu Glu Gln Val Ala Arg Glu His Glu Glu 
    210                 215                 220                 


Tyr Gln Ala Gly Val Asp Glu Phe Gln Leu Trp Leu Lys Ala Val Val 
225                 230                 235                 240 


Glu Lys Val Asn Gly Cys Leu Gly Arg Asn Cys Lys Leu Pro Ile Thr 
                245                 250                 255     


Gln Arg Leu Ser Thr Leu Gln Asp Ile Ala Lys Asp Phe Pro Arg Gly 
            260                 265                 270         


Glu Glu Ser Leu Glu Thr Leu Glu Glu Gln Ser Ala Gly Val Ile Arg 
        275                 280                 285             


Asn Thr Ser Pro Leu Gly Ala Glu Lys Ile Thr Gly Glu Leu Glu Glu 
    290                 295                 300                 


Met Arg Lys Val Leu Glu Lys Leu Arg Ala Leu Trp Glu Glu Glu Glu 
305                 310                 315                 320 


Glu Arg Leu Arg Gly Leu Leu Arg Ser Arg Gly Ala Trp Glu Gln Gln 
                325                 330                 335     


Ile Lys Gln Leu Glu Ala Glu Leu Ser Glu Phe Arg Met Val Leu Gln 
            340                 345                 350         


Arg Leu Ala Gln Glu Gly Leu Gln Pro Ala Ala Lys Ala Gly Thr Glu 
        355                 360                 365             


Asp Glu Leu Val Ala His Trp Arg Arg Tyr Ser Ala Thr Arg Ala Ala 
    370                 375                 380                 


Leu Ala Ser Glu Glu Pro Arg Val Asp Arg Leu Gln Ala Gln Leu Lys 
385                 390                 395                 400 


Glu Leu Ile Val Phe Pro His Asn Leu Lys Pro Leu Ser Asp Ser Val 
                405                 410                 415     


Ile Ala Thr Ile Gln Glu Tyr Gln Ser Leu Lys Val Lys Ser Ala Arg 
            420                 425                 430         


Leu Arg Asn Ala Ala Ala Val Glu Leu Trp Gln His Phe Gln Arg Pro 
        435                 440                 445             


Leu Gln Asp Leu Gln Leu Trp Lys Ala Leu Ala Gln Arg Leu Leu Glu 
    450                 455                 460                 


Val Thr Ala Ser Leu Pro Asp Leu Pro Ser Leu His Thr Phe Leu Pro 
465                 470                 475                 480 


Gln Ile Glu Ala Ala Leu Met Glu Ser Ser Arg Leu Lys Glu Leu Leu 
                485                 490                 495     


Thr Met Leu Gln Leu Lys Lys Asp Leu Leu Ile Gly Ile Phe Gly Gln 
            500                 505                 510         


Glu Arg Ala Thr Ala Leu Leu Glu Gln Val Ala Gly Ser Met Arg Asp 
        515                 520                 525             


Arg Asp Leu Leu His Asn Ser Leu Leu Gln Arg Lys Ser Lys Leu Gln 
    530                 535                 540                 


Ser Leu Leu Ala Gln His Lys Asp Phe Gly Ala Ala Phe Glu Pro Leu 
545                 550                 555                 560 


Gln Arg Lys Leu Leu Asp Leu Gln Val Arg Val Gln Ala Glu Lys Gly 
                565                 570                 575     


Leu Gln Arg Asp Leu Pro Gly Lys Gln Ala Gln Leu Ser Arg Leu Gln 
            580                 585                 590         


Gly Leu Gln Glu Glu Gly Leu Asp Leu Gly Ala Gln Met Glu Ala Ala 
        595                 600                 605             


Arg Pro Leu Val Gln Glu Asn Pro Asn His Gln His Lys Met Asp Gln 
    610                 615                 620                 


Leu Ser Ser Asp Phe Gln Ala Leu Gln Arg Ser Leu Glu Asp Leu Val 
625                 630                 635                 640 


Asp Arg Cys Arg Gln Ser Val Gln Glu His Cys Thr Phe Ser His Gln 
                645                 650                 655     


Leu Leu Glu Leu Arg Gln Trp Ile Val Val Thr Thr Gln Lys Leu Glu 
            660                 665                 670         


Ala His Arg Gly Glu Ala Gly Pro Gly Asp Ala Glu Ser Gln Glu Ala 
        675                 680                 685             


Glu Phe Glu Arg Leu Val Ala Glu Phe Pro Glu Lys Glu Ala Gln Leu 
    690                 695                 700                 


Ser Leu Val Glu Ala Gln Gly Trp Leu Val Met Glu Lys Ser Ser Pro 
705                 710                 715                 720 


Glu Gly Ala Ala Val Val Gln Glu Glu Leu Arg Glu Leu Ala Glu Ser 
                725                 730                 735     


Trp Arg Ala Leu Arg Leu Leu Glu Glu Ser Leu Leu Ser Leu Ile Arg 
            740                 745                 750         


Asn Trp His Leu Gln Arg Met Glu Val Asp Ser Gly Lys Lys Met Val 
        755                 760                 765             


Phe Thr Asn Asn Ile Pro Lys Ser Gly Phe Leu Ile Asn Pro Met Asp 
    770                 775                 780                 


Pro Ile Pro Arg His Arg Arg Arg Ala Asn Leu Leu Gln Glu Glu Glu 
785                 790                 795                 800 


Gly Ser His Glu Asp Phe Ser Gln Leu Leu Arg Asn Phe Gly Gln Trp 
                805                 810                 815     


Leu Gln Val Glu Asn Ser Lys Leu Val Arg Ile Ile Ala Met Arg Thr 
            820                 825                 830         


Ser Thr Ala Glu Asp Leu Arg Thr Arg Lys Ser Lys Leu Gln Glu Leu 
        835                 840                 845             


Glu Ala Arg Val Pro Glu Gly Gln His Leu Phe Glu Asn Leu Leu Arg 
    850                 855                 860                 


Leu Gly Pro Ala Arg Gly Thr Ser Asp Glu Leu Glu Asp Leu Arg Tyr 
865                 870                 875                 880 


Gln Trp Met Leu Tyr Lys Ser Lys Leu Lys Asp Ser Gly His Leu Leu 
                885                 890                 895     


Thr Gln Ser Ser Pro Gly Glu Pro Thr Gly Phe Gln Lys Thr Arg Arg 
            900                 905                 910         


Trp Arg Gly Leu Gly Ser Leu Phe Arg Arg Ala Cys Cys Val Ala Leu 
        915                 920                 925             


Pro Leu Gln Leu Leu Leu Leu Leu Phe Leu Leu Leu Leu Phe Leu Leu 
    930                 935                 940                 


Pro Ile Arg Glu Glu Asp Arg Ser Cys Thr Leu Ala Asn Asn Phe Ala 
945                 950                 955                 960 


Arg Ser Phe Thr Leu Met Leu Arg Tyr Asn Gly Pro Pro Pro Thr 
                965                 970                 975 


<210>  6087
<211>  586
<212>  PRT
<213>  Homo sapiens

<400>  6087

Met Ser Ala Asn Pro Arg Trp Asp Ile Ser Arg Ala Leu Gly Val Ala 
1               5                   10                  15      


Lys Leu Phe His Leu Val Cys Gly Val Arg Glu Ala Cys Val Thr Pro 
            20                  25                  30          


Phe Leu Thr Leu Tyr Leu Arg Gln Leu Gly Leu Ala Ala Pro Trp Val 
        35                  40                  45              


Gly Thr Leu Met Gly Thr Lys His Leu Ile Ala Ala Phe Trp Ala Pro 
    50                  55                  60                  


Val Cys Ala Phe Leu Ala Lys Ser Tyr Arg Lys Arg Arg Ala Leu Leu 
65                  70                  75                  80  


Ile Gly Ser Leu Leu Gly Ser Val Gly Ala Ser Leu Leu Met Val Leu 
                85                  90                  95      


Val Pro Pro Val Asp Lys Asn Arg Val His Phe Pro Cys Asn Gly Ser 
            100                 105                 110         


Ser Gly Leu Thr Ser Thr Asp Ala Leu Pro Gly Val Thr Leu Pro Val 
        115                 120                 125             


Asn Ile Thr Ser Ala Gln Glu Ser Ala Ser Ser His Pro Ala Lys Arg 
    130                 135                 140                 


Thr Ala Glu Val Glu Met Pro Gly Phe Arg Asn Pro Pro Gly Glu Ser 
145                 150                 155                 160 


Asp Arg Glu Thr Phe Arg Asp Leu His Val Tyr Leu Ala Pro Ser Val 
                165                 170                 175     


Glu Gly Ala Arg Thr Thr Ser Gln Ala Leu Leu His Pro Val Thr Ser 
            180                 185                 190         


Gly Leu Lys Asp His Pro Trp Glu Val Thr Phe Glu Val Val Lys Thr 
        195                 200                 205             


Ala Leu Pro Leu Leu Pro Gly Gly Lys Gly Pro Gly Asn Pro Ala Asn 
    210                 215                 220                 


Leu Ser Gly Thr Lys Gly Lys Ala Trp Ala Phe Asp Leu Ser Leu Glu 
225                 230                 235                 240 


Ala Leu Arg Arg Thr Phe Ile Leu Ser Leu Gly Ser Val Ala Phe Trp 
                245                 250                 255     


Glu Leu Leu Thr Ala Pro Leu Glu Gln Val Ala Asp Asp Ser Leu Tyr 
            260                 265                 270         


Glu Phe Leu Asp Phe Val Asp Ala Thr Asp Arg Tyr Arg Ser Leu Trp 
        275                 280                 285             


Val Trp Arg Leu Leu Gly Met Ser Ala Gly Val Cys Gly Ile Thr Ala 
    290                 295                 300                 


Leu Val Gly Gln Leu Asp Cys Phe Leu Met Thr Ser Gly Pro Arg Gly 
305                 310                 315                 320 


Val Val His Phe Tyr Gly Tyr Ser Val Val Ser Thr Leu Ala Leu Leu 
                325                 330                 335     


Val Ser Ile Ala Phe Pro Ile Pro Ile Cys Gln Gln Trp Glu Pro Ser 
            340                 345                 350         


Tyr Lys Arg Val Lys Ala Leu Ser Ile Val Gly Gly Asp Pro His Leu 
        355                 360                 365             


Ile Leu Leu Ala Ser Thr Thr Val Leu Val Gly Ala Ile Val Ser Thr 
    370                 375                 380                 


Val Gln Asn Phe Leu Phe Trp His Met Lys Asp His Gly Ser Gly Glu 
385                 390                 395                 400 


Leu Val Met Gly Phe Ser Val Ala Leu Ser Leu Leu Gly Glu Ile Leu 
                405                 410                 415     


Leu His Pro Phe Lys Ala Thr Leu Leu Arg Lys Leu Ser Arg Thr Gly 
            420                 425                 430         


Leu Val Gly Leu Gly Leu Ser Cys Leu Ala Gly Gln Leu Leu Tyr Tyr 
        435                 440                 445             


Ser Phe Leu Trp Ser Trp Trp Ser Val Leu Pro Ile Gln Ile Leu Ser 
    450                 455                 460                 


Ala Ile Ser Asn Arg Ala Leu Trp Trp Ala Val Gly Ala Ser Val Glu 
465                 470                 475                 480 


Asp Leu Ala Thr Pro Arg Met Glu Arg Ala Leu Ser Ala Leu Phe Arg 
                485                 490                 495     


Gly His Phe Tyr Gly Ser Gly Cys Ser Leu Gly Ser Phe Val Gly Gly 
            500                 505                 510         


Phe Val Val Met Arg Phe Ser Leu Ala Val Leu Tyr Gln Ala Cys Cys 
        515                 520                 525             


Val Ala Leu Leu Leu Trp Leu Ala Leu Leu Leu Ser Ile Gln Arg Arg 
    530                 535                 540                 


Leu Pro Arg Glu Arg Lys Ile Lys Tyr Ser Lys Leu Leu Ser Met Glu 
545                 550                 555                 560 


Val Ser Asp Thr Ser Asp Ser Glu Gln Gly Thr Glu Gln Asp Trp Leu 
                565                 570                 575     


Val Lys Ala Met Arg Glu Glu His Ser Asp 
            580                 585     


<210>  6088
<211>  725
<212>  PRT
<213>  Homo sapiens

<400>  6088

Met Asp Asp Ser Asp Thr Pro Thr Tyr Tyr Leu Gln Ile Glu Pro Gln 
1               5                   10                  15      


Asp Gly Cys His Pro Gly Asp Ser Val Glu Arg Ser Val Thr Cys Leu 
            20                  25                  30          


Pro Ser Ala Ser Asp Glu Asn Glu Asn Gln Leu Asp Gly Asp Gly His 
        35                  40                  45              


Glu His Leu Thr Ser Ser Asp Ser Ala Met Gly Lys Pro Gln Val Ser 
    50                  55                  60                  


Glu Gln Asp Ser Leu Asn Asn Asn Glu Ser Cys Thr Leu Ser Cys Glu 
65                  70                  75                  80  


Val Ala Ala Gly Glu Asn Leu Gln Asn Thr Leu Cys Glu Ala Ser Arg 
                85                  90                  95      


Asp Glu Gln Ala Phe Leu Gly Lys Asp Lys Lys Ile Pro Gly Lys Arg 
            100                 105                 110         


Ser Pro Arg Ser Lys Lys Gly Thr Ala Lys Lys Ile Pro Pro Gly Leu 
        115                 120                 125             


Phe Ser Gly Asp Ile Ala Pro Leu Met Gln Glu Lys Val Leu Ser Ala 
    130                 135                 140                 


Val Thr Tyr Ala Val Asp Asp Glu Glu Ala Ala Glu Val Asn Ala Asn 
145                 150                 155                 160 


Glu Gln Pro Glu Ala Pro Lys Leu Val Leu Gln Ser Leu Phe Ser Leu 
                165                 170                 175     


Ile Arg Gly Glu Val Glu Gln Leu Asp Ser Arg Ala Leu Pro Leu Cys 
            180                 185                 190         


Leu His Gln Ile Ala Glu Ser Tyr Phe Gln Glu Glu Asp Tyr Glu Lys 
        195                 200                 205             


Ala Met Lys Phe Ile Gln Leu Glu Arg Leu Tyr His Glu Gln Leu Leu 
    210                 215                 220                 


Ala Asn Leu Ser Ala Ile Gln Glu Gln Trp Glu Thr Lys Trp Lys Thr 
225                 230                 235                 240 


Val Gln Pro His Thr Val Thr Ala Leu Arg Asn Ser Glu Lys Gly Phe 
                245                 250                 255     


Asn Gly Glu Asp Phe Glu Arg Leu Thr Lys Ile Cys Ala Thr His Gln 
            260                 265                 270         


Asp Pro Leu Leu Ser Lys His Lys Ile Ala Ala Val Glu Lys Ser Gln 
        275                 280                 285             


Glu Arg Lys Cys Ser Thr Gln Leu Leu Val Ser Glu Asp Pro Lys Glu 
    290                 295                 300                 


Gly Gly Ala Thr Thr Lys Glu Ser Glu Ser Lys Thr Cys Leu Gly Thr 
305                 310                 315                 320 


Glu Ser Ser Lys Glu Ser Gln His Thr Val Glu Pro Leu Gly Ser Ser 
                325                 330                 335     


Pro Cys Cys His Gln Met Asp Val Gln Thr Asp Ser Pro Ser Leu Ser 
            340                 345                 350         


Val Thr Ala Gly Lys Asp His Met Glu Glu Leu Leu Cys Ser Ala Glu 
        355                 360                 365             


Ala Thr Leu Ala Leu His Thr Gln Ser Ser Glu Thr Ala Gly Ser Pro 
    370                 375                 380                 


Ser Gly Pro Asp Ser Ser Glu Asp Ala Cys Glu Asp Asp Ser Arg Leu 
385                 390                 395                 400 


Gln Leu Ala Gln Thr Glu Ala Cys Gln Asp Val Ala Arg Ile Glu Gly 
                405                 410                 415     


Ile Ala Glu Asp Pro Lys Val Phe Leu Ser Ser Lys Ser Lys Thr Glu 
            420                 425                 430         


Pro Leu Ile Ser Pro Gly Cys Asp Arg Ile Pro Pro Ala Leu Ile Ser 
        435                 440                 445             


Glu Gly Lys Tyr Ser Gln Ala Gln Arg Lys Glu Leu Arg Leu Pro Leu 
    450                 455                 460                 


Arg Asp Ala Ser Glu Ala Leu Pro Thr Asp Gln Leu Glu Asn Asn Glu 
465                 470                 475                 480 


Leu Asn Glu Leu Gln Gln Pro Asp Leu Thr Asp Ser Asp Gly Lys Ser 
                485                 490                 495     


Pro Gln Ala Gln Ala Asp Ser Asp Gly Ser Glu Asn Val Leu Cys Gly 
            500                 505                 510         


Asn Asn Gln Ile Ser Asp Leu Gly Ile Leu Leu Pro Glu Val Cys Met 
        515                 520                 525             


Ala Pro Glu Glu Lys Gly Asp Lys Asp Asp Gln Leu Asn Lys Glu Thr 
    530                 535                 540                 


Glu Asp Tyr Leu Asn Ser Leu Leu Glu Gly Cys Leu Lys Asp Thr Glu 
545                 550                 555                 560 


Asp Ser Leu Ser Tyr Glu Asp Asn Gln Asp Asp Asp Ser Asp Leu Leu 
                565                 570                 575     


Gln Asp Leu Ser Pro Glu Glu Ala Ser Tyr Ser Leu Gln Glu Asn Leu 
            580                 585                 590         


Pro Ser Asp Glu Ser Cys Leu Ser Leu Asp Asp Leu Ala Lys Arg Ile 
        595                 600                 605             


Glu Ile Ala Glu Val Val Pro Thr Glu Gly Leu Val Ser Ile Leu Lys 
    610                 615                 620                 


Lys Arg Asn Asp Thr Val Gly Asp His Pro Ala Gln Met Gln His Lys 
625                 630                 635                 640 


Pro Ser Lys Arg Arg Val Arg Phe Gln Glu Ile Asp Asp Ser Leu Asp 
                645                 650                 655     


Gln Asp Glu Val Gly Gly Gly Ser Cys Ile Leu Leu Val Leu Leu Cys 
            660                 665                 670         


Ile Ala Thr Val Phe Leu Ser Val Gly Gly Thr Ala Leu Tyr Cys Thr 
        675                 680                 685             


Phe Gly Asp Met Glu Ser Pro Val Cys Thr Asp Phe Ala Asp Asn Met 
    690                 695                 700                 


Asp Phe Tyr Tyr Thr Lys Leu Leu Gln Gly Val Ala Glu Leu Lys His 
705                 710                 715                 720 


Trp Ile Tyr Leu Ser 
                725 


<210>  6089
<211>  740
<212>  PRT
<213>  Homo sapiens

<400>  6089

Met Arg Gln Thr Leu Pro Leu Leu Leu Leu Thr Val Leu Arg Pro Ser 
1               5                   10                  15      


Trp Ala Asp Pro Pro Gln Glu Lys Val Pro Leu Phe Arg Val Thr Gln 
            20                  25                  30          


Gln Gly Pro Trp Gly Ser Ser Gly Ser Asn Ala Thr Asp Ser Pro Cys 
        35                  40                  45              


Glu Gly Leu Pro Ala Ala Asp Ala Thr Ala Leu Thr Leu Ala Asn Arg 
    50                  55                  60                  


Asn Leu Glu Arg Leu Pro Gly Cys Leu Pro Arg Thr Leu Arg Ser Leu 
65                  70                  75                  80  


Asp Ala Ser His Asn Leu Leu Arg Ala Leu Ser Thr Ser Glu Leu Gly 
                85                  90                  95      


His Leu Glu Gln Leu Gln Val Leu Thr Leu Arg His Asn Arg Ile Ala 
            100                 105                 110         


Ala Leu Arg Trp Gly Pro Gly Gly Pro Ala Gly Leu His Thr Leu Asp 
        115                 120                 125             


Leu Ser Tyr Asn Gln Leu Ala Ala Leu Pro Pro Cys Thr Gly Pro Ala 
    130                 135                 140                 


Leu Ser Ser Leu Arg Ala Leu Ala Leu Ala Gly Asn Pro Leu Arg Ala 
145                 150                 155                 160 


Leu Gln Pro Arg Ala Phe Ala Cys Phe Pro Ala Leu Gln Leu Leu Asn 
                165                 170                 175     


Leu Ser Cys Thr Ala Leu Gly Arg Gly Ala Gln Gly Gly Ile Ala Glu 
            180                 185                 190         


Ala Ala Phe Ala Gly Glu Asp Gly Ala Pro Leu Val Thr Leu Glu Val 
        195                 200                 205             


Leu Asp Leu Ser Gly Thr Phe Leu Glu Arg Val Glu Ser Gly Trp Ile 
    210                 215                 220                 


Arg Asp Leu Pro Lys Leu Thr Ser Leu Tyr Leu Arg Lys Met Pro Arg 
225                 230                 235                 240 


Leu Thr Thr Leu Glu Gly Asp Ile Phe Lys Met Thr Pro Asn Leu Gln 
                245                 250                 255     


Gln Leu Asp Cys Gln Asp Ser Pro Ala Leu Ala Ser Val Ala Thr His 
            260                 265                 270         


Ile Phe Gln Asp Thr Pro His Leu Gln Val Leu Leu Phe Gln Asn Cys 
        275                 280                 285             


Asn Leu Ser Ser Phe Pro Pro Trp Thr Leu Asp Ser Ser Gln Val Leu 
    290                 295                 300                 


Ser Ile Asn Leu Phe Gly Asn Pro Leu Thr Cys Ser Cys Asp Leu Ser 
305                 310                 315                 320 


Trp Leu Leu Thr Asp Ala Lys Arg Thr Val Leu Ser Arg Ala Ala Asp 
                325                 330                 335     


Thr Met Cys Ala Pro Ala Ala Gly Ser Ser Gly Pro Phe Ser Ala Ser 
            340                 345                 350         


Leu Ser Leu Ser Gln Leu Pro Gly Val Cys Gln Ser Asp Gln Ser Thr 
        355                 360                 365             


Thr Leu Gly Ala Ser His Pro Pro Cys Phe Asn Arg Ser Thr Tyr Ala 
    370                 375                 380                 


Gln Gly Thr Thr Val Ala Pro Ser Ala Ala Pro Ala Thr Arg Pro Ala 
385                 390                 395                 400 


Gly Asp Gln Gln Ser Val Ser Lys Ala Pro Asn Val Gly Ser Arg Thr 
                405                 410                 415     


Ile Ala Ala Trp Pro His Ser Asp Ala Arg Glu Gly Thr Ala Pro Ser 
            420                 425                 430         


Thr Thr Asn Ser Val Ala Gly His Ser Asn Ser Ser Val Phe Pro Arg 
        435                 440                 445             


Ala Ala Ser Thr Thr Arg Thr Gln His Arg Gly Glu His Ala Pro Glu 
    450                 455                 460                 


Leu Val Leu Glu Pro Asp Ile Ser Ala Ala Ser Thr Pro Leu Ala Ser 
465                 470                 475                 480 


Lys Leu Leu Gly Pro Phe Pro Thr Ser Trp Asp Arg Ser Ile Ser Ser 
                485                 490                 495     


Pro Gln Pro Gly Gln Arg Thr His Ala Thr Pro Gln Ala Pro Asn Pro 
            500                 505                 510         


Ser Leu Ser Glu Gly Glu Ile Pro Val Leu Leu Leu Asp Asp Tyr Ser 
        515                 520                 525             


Glu Glu Glu Glu Gly Arg Lys Glu Glu Val Gly Thr Pro His Gln Asp 
    530                 535                 540                 


Val Pro Cys Asp Tyr His Pro Cys Lys His Leu Gln Thr Pro Cys Ala 
545                 550                 555                 560 


Glu Leu Gln Arg Arg Trp Arg Cys Arg Cys Pro Gly Leu Ser Gly Glu 
                565                 570                 575     


Asp Thr Ile Pro Asp Pro Pro Arg Leu Gln Gly Val Thr Glu Thr Thr 
            580                 585                 590         


Asp Thr Ser Ala Leu Val His Trp Cys Ala Pro Asn Ser Val Val His 
        595                 600                 605             


Gly Tyr Gln Ile Arg Tyr Ser Ala Glu Gly Trp Ala Gly Asn Gln Ser 
    610                 615                 620                 


Val Val Gly Val Ile Tyr Ala Thr Ala Arg Gln His Pro Leu Tyr Gly 
625                 630                 635                 640 


Leu Ser Pro Gly Thr Thr Tyr Arg Val Cys Val Leu Ala Ala Asn Arg 
                645                 650                 655     


Ala Gly Leu Ser Gln Pro Arg Ser Ser Gly Trp Arg Ser Pro Cys Ala 
            660                 665                 670         


Ala Phe Thr Thr Lys Pro Ser Phe Ala Leu Leu Leu Ser Gly Leu Cys 
        675                 680                 685             


Ala Ala Ser Gly Leu Leu Leu Ala Ser Thr Val Val Leu Ser Ala Cys 
    690                 695                 700                 


Leu Cys Arg Arg Gly Gln Thr Leu Gly Leu Gln Arg Cys Asp Thr His 
705                 710                 715                 720 


Leu Val Ala Tyr Lys Asn Pro Ala Phe Asp Asp Tyr Pro Leu Gly Leu 
                725                 730                 735     


Gln Thr Val Ser 
            740 


<210>  6090
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  6090

Met Asp Ile Ile Glu Thr Ala Lys Leu Glu Glu His Leu Glu Asn Gln 
1               5                   10                  15      


Pro Ser Asp Pro Thr Asn Thr Tyr Ala Arg Pro Ala Glu Pro Val Glu 
            20                  25                  30          


Glu Glu Asn Lys Asn Gly Asn Gly Lys Pro Lys Ser Leu Ser Ser Gly 
        35                  40                  45              


Leu Arg Lys Gly Thr Lys Lys Tyr Pro Asp Tyr Ile Gln Ile Ala Met 
    50                  55                  60                  


Pro Thr Glu Ser Arg Asn Lys Phe Pro Leu Glu Trp Trp Lys Thr Gly 
65                  70                  75                  80  


Ile Ala Phe Ile Tyr Ala Val Phe Asn Leu Val Leu Thr Thr Val Met 
                85                  90                  95      


Ile Thr Val Val His Glu Arg Val Pro Pro Lys Glu Leu Ser Pro Pro 
            100                 105                 110         


Leu Pro Asp Lys Phe Phe Asp Tyr Ile Asp Arg Val Lys Trp Ala Phe 
        115                 120                 125             


Ser Val Ser Glu Ile Asn Gly Ile Ile Leu Val Gly Leu Trp Ile Thr 
    130                 135                 140                 


Gln Trp Leu Phe Leu Arg Tyr Lys Ser Ile Val Gly Arg Arg Phe Cys 
145                 150                 155                 160 


Phe Ile Ile Gly Thr Leu Tyr Leu Tyr Arg Cys Ile Thr Met Tyr Val 
                165                 170                 175     


Thr Thr Leu Pro Val Pro Gly Met His Phe Gln Cys Ala Pro Lys Leu 
            180                 185                 190         


Asn Gly Asp Ser Gln Ala Lys Val Gln Arg Ile Leu Arg Leu Ile Ser 
        195                 200                 205             


Gly Gly Gly Leu Ser Ile Thr Gly Ser His Ile Leu Cys Gly Asp Phe 
    210                 215                 220                 


Leu Phe Ser Gly His Thr Val Thr Leu Thr Leu Thr Tyr Leu Phe Ile 
225                 230                 235                 240 


Lys Glu Tyr Ser Pro Arg His Phe Trp Trp Tyr His Leu Ile Cys Trp 
                245                 250                 255     


Leu Leu Ser Ala Ala Gly Ile Ile Cys Ile Leu Val Ala His Glu His 
            260                 265                 270         


Tyr Thr Ile Asp Val Ile Ile Ala Tyr Tyr Ile Thr Thr Arg Leu Phe 
        275                 280                 285             


Trp Trp Tyr His Ser Met Ala Asn Glu Lys Asn Leu Lys Val Ser Ser 
    290                 295                 300                 


Gln Thr Asn Phe Leu Ser Arg Ala Trp Trp Phe Pro Ile Phe Tyr Phe 
305                 310                 315                 320 


Phe Glu Lys Asn Val Gln Gly Ser Ile Pro Cys Cys Phe Ser Trp Pro 
                325                 330                 335     


Leu Ser Trp Pro Pro Gly Cys Phe Lys Ser Ser Cys Lys Lys Tyr Ser 
            340                 345                 350         


Arg Val Gln Lys Ile Gly Glu Asp Asn Glu Lys Ser Thr 
        355                 360                 365 


<210>  6091
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  6091

Met Asp Ile Leu Val Pro Leu Leu Gln Leu Leu Val Leu Leu Leu Thr 
1               5                   10                  15      


Leu Pro Leu His Leu Met Ala Leu Leu Gly Cys Trp Gln Pro Leu Cys 
            20                  25                  30          


Lys Ser Tyr Phe Pro Tyr Leu Met Ala Val Leu Thr Pro Lys Ser Asn 
        35                  40                  45              


Arg Lys Met Glu Ser Lys Lys Arg Glu Leu Phe Ser Gln Ile Lys Gly 
    50                  55                  60                  


Leu Thr Gly Ala Ser Gly Lys Val Ala Leu Leu Glu Leu Gly Cys Gly 
65                  70                  75                  80  


Thr Gly Ala Asn Phe Gln Phe Tyr Pro Pro Gly Cys Arg Val Thr Cys 
                85                  90                  95      


Leu Asp Pro Asn Pro His Phe Glu Lys Phe Leu Thr Lys Ser Met Ala 
            100                 105                 110         


Glu Asn Arg His Leu Gln Tyr Glu Arg Phe Val Val Ala Pro Gly Glu 
        115                 120                 125             


Asp Met Arg Gln Leu Ala Asp Gly Ser Met Asp Val Val Val Cys Thr 
    130                 135                 140                 


Leu Val Leu Cys Ser Val Gln Ser Pro Arg Lys Val Leu Gln Glu Val 
145                 150                 155                 160 


Arg Arg Val Leu Arg Pro Gly Gly Val Leu Phe Phe Trp Glu His Val 
                165                 170                 175     


Ala Glu Pro Tyr Gly Ser Trp Ala Phe Met Trp Gln Gln Val Phe Glu 
            180                 185                 190         


Pro Thr Trp Lys His Ile Gly Asp Gly Cys Cys Leu Thr Arg Glu Thr 
        195                 200                 205             


Trp Lys Asp Leu Glu Asn Ala Gln Phe Ser Glu Ile Gln Met Glu Arg 
    210                 215                 220                 


Gln Pro Pro Pro Leu Lys Trp Leu Pro Val Gly Pro His Ile Met Gly 
225                 230                 235                 240 


Lys Ala Val Lys 
                


<210>  6092
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  6092

Met Pro Val Ile Ala Gly Gly Ile Leu Ala Ala Leu Leu Leu Leu Ile 
1               5                   10                  15      


Val Val Val Leu Cys Leu Tyr Phe Lys Ile His Asn Ala Leu Lys Ala 
            20                  25                  30          


Ala Lys Glu Pro Glu Ala Val Ala Val Lys Asn His Asn Pro Asp Lys 
        35                  40                  45              


Val Trp Trp Ala Lys Asn Ser Gln Ala Lys Thr Ile Ala Thr Glu Ser 
    50                  55                  60                  


Cys Pro Ala Leu Gln Cys Cys Glu Gly Tyr Arg Met Cys Ala Ser Phe 
65                  70                  75                  80  


Asp Ser Leu Pro Pro Cys Cys Cys Asp Ile Asn Glu Gly Leu 
                85                  90                  


<210>  6093
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  6093

Met Glu Ile Arg Gln His Glu Trp Leu Ser Ala Ser Pro His Glu Gly 
1               5                   10                  15      


Phe Glu Gln Met Arg Leu Lys Ser Arg Pro Lys Glu Pro Ser Pro Ser 
            20                  25                  30          


Leu Thr Arg Val Gly Ala Asn Phe Tyr Ser Ser Val Lys Gln Gln Asp 
        35                  40                  45              


Tyr Ser Ala Ser Val Trp Leu Arg Arg Lys Asp Lys Leu Glu His Ser 
    50                  55                  60                  


Gln Gln Lys Cys Ile Val Ile Phe Ala Leu Val Cys Cys Phe Ala Ile 
65                  70                  75                  80  


Leu Val Ala Leu Ile Phe Ser Ala Val Asp Ile Met Gly Glu Asp Glu 
                85                  90                  95      


Asp Gly Leu Ser Glu Lys Asn Cys Gln Asn Lys Cys Arg Ile Ala Leu 
            100                 105                 110         


Val Glu Asn Ile Pro Glu Gly Leu Asn Tyr Ser Glu Asn Ala Pro Phe 
        115                 120                 125             


His Leu Ser Leu Phe Gln Gly Trp Met Asn Leu Leu Asn Met Ala Lys 
    130                 135                 140                 


Lys Ser Val Asp Ile Val Ser Ser His Trp Asp Leu Asn His Thr His 
145                 150                 155                 160 


Pro Ser Ala Cys Gln Gly Gln Arg Leu Phe Glu Lys Leu Leu Gln Leu 
                165                 170                 175     


Thr Ser Gln Asn Ile Glu Ile Lys Leu Val Ser Asp Val Thr Ala Asp 
            180                 185                 190         


Ser Lys Val Leu Glu Ala Leu Lys Leu Lys Gly Ala Glu Val Thr Tyr 
        195                 200                 205             


Met Asn Met Thr Ala Tyr Asn Lys Gly Arg Leu Gln Ser Ser Phe Trp 
    210                 215                 220                 


Ile Val Asp Lys Gln His Val Tyr Ile Gly Ser Ala Gly Leu Asp Trp 
225                 230                 235                 240 


Gln Ser Leu Gly Gln Met Lys Glu Leu Gly Val Ile Phe Tyr Asn Cys 
                245                 250                 255     


Ser Cys Leu Val Leu Asp Leu Gln Arg Ile Phe Ala Leu Tyr Ser Ser 
            260                 265                 270         


Leu Lys Phe Lys Ser Arg Val Pro Gln Thr Trp Ser Lys Arg Leu Tyr 
        275                 280                 285             


Gly Val Tyr Asp Asn Glu Lys Lys Leu Gln Leu Gln Leu Asn Glu Thr 
    290                 295                 300                 


Lys Ser Gln Ala Phe Val Ser Asn Ser Pro Lys Leu Phe Cys Pro Lys 
305                 310                 315                 320 


Asn Arg Ser Phe Asp Ile Asp Ala Ile Tyr Ser Val Ile Asp Asp Ala 
                325                 330                 335     


Lys Gln Tyr Val Tyr Ile Ala Val Met Asp Tyr Leu Pro Ile Ser Ser 
            340                 345                 350         


Thr Ser Thr Lys Arg Thr Tyr Trp Pro Asp Leu Asp Ala Lys Ile Arg 
        355                 360                 365             


Glu Ala Leu Val Leu Arg Ser Val Arg Val Arg Leu Leu Leu Ser Phe 
    370                 375                 380                 


Trp Lys Glu Thr Asp Pro Leu Thr Phe Asn Phe Ile Ser Ser Leu Lys 
385                 390                 395                 400 


Ala Ile Cys Thr Glu Ile Ala Asn Cys Ser Leu Lys Val Lys Phe Phe 
                405                 410                 415     


Asp Leu Glu Arg Glu Asn Ala Cys Ala Thr Lys Glu Gln Lys Asn His 
            420                 425                 430         


Thr Phe Pro Arg Leu Asn Arg Asn Lys Tyr Met Val Thr Asp Gly Ala 
        435                 440                 445             


Ala Tyr Ile Gly Asn Phe Asp Trp Val Gly Asn Asp Phe Thr Gln Asn 
    450                 455                 460                 


Ala Gly Thr Gly Leu Val Ile Asn Gln Ala Asp Val Arg Asn Asn Arg 
465                 470                 475                 480 


Ser Ile Ile Lys Gln Leu Lys Asp Val Phe Glu Arg Asp Trp Tyr Ser 
                485                 490                 495     


Pro Tyr Ala Lys Thr Leu Gln Pro Thr Lys Gln Pro Asn Cys Ser Ser 
            500                 505                 510         


Leu Phe Lys Leu Lys Pro Leu Ser Asn Lys Thr Ala Thr Asp Asp Thr 
        515                 520                 525             


Gly Gly Lys Asp Pro Arg Asn Val 
    530                 535     


<210>  6094
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  6094

Met Glu Pro Gly Arg Thr Gln Ile Lys Leu Asp Pro Arg Tyr Thr Ala 
1               5                   10                  15      


Asp Leu Leu Glu Val Leu Lys Thr Asn Tyr Gly Ile Pro Ser Ala Cys 
            20                  25                  30          


Phe Ser Gln Pro Pro Thr Ala Ala Gln Leu Leu Arg Ala Leu Gly Pro 
        35                  40                  45              


Val Glu Leu Ala Leu Thr Ser Ile Leu Thr Leu Leu Ala Leu Gly Ser 
    50                  55                  60                  


Ile Ala Ile Phe Leu Glu Asp Ala Val Tyr Leu Tyr Lys Asn Thr Leu 
65                  70                  75                  80  


Cys Pro Ile Lys Arg Arg Thr Leu Leu Trp Lys Ser Ser Ala Pro Thr 
                85                  90                  95      


Val Val Ser Val Leu Cys Cys Phe Gly Leu Trp Ile Pro Arg Ser Leu 
            100                 105                 110         


Val Leu Val Glu Met Thr Ile Thr Ser Phe Tyr Ala Val Cys Phe Tyr 
        115                 120                 125             


Leu Leu Met Leu Val Met Val Glu Gly Phe Gly Gly Lys Glu Ala Val 
    130                 135                 140                 


Leu Arg Thr Leu Arg Asp Thr Pro Met Met Val His Thr Gly Pro Cys 
145                 150                 155                 160 


Cys Cys Cys Cys Pro Cys Cys Pro Arg Leu Leu Leu Thr Arg Lys Lys 
                165                 170                 175     


Leu Gln Leu Leu Met Leu Gly Pro Phe Gln Tyr Ala Phe Leu Lys Ile 
            180                 185                 190         


Thr Leu Thr Leu Val Gly Leu Phe Leu Val Pro Asp Gly Ile Tyr Asp 
        195                 200                 205             


Pro Ala Asp Ile Ser Glu Gly Ser Thr Ala Leu Trp Ile Asn Thr Phe 
    210                 215                 220                 


Leu Gly Val Ser Thr Leu Leu Ala Leu Trp Thr Leu Gly Ile Ile Ser 
225                 230                 235                 240 


Arg Gln Ala Arg Leu His Leu Gly Glu Gln Asn Met Gly Ala Lys Phe 
                245                 250                 255     


Ala Leu Phe Gln Val Leu Leu Ile Leu Thr Ala Leu Gln Pro Ser Ile 
            260                 265                 270         


Phe Ser Val Leu Ala Asn Gly Gly Gln Ile Ala Cys Ser Pro Pro Tyr 
        275                 280                 285             


Ser Ser Lys Thr Arg Ser Gln Val Met Asn Cys His Leu Leu Ile Leu 
    290                 295                 300                 


Glu Thr Phe Leu Met Thr Val Leu Thr Arg Met Tyr Tyr Arg Arg Lys 
305                 310                 315                 320 


Asp His Lys Val Gly Tyr Glu Thr Phe Ser Ser Pro Asp Leu Asp Leu 
                325                 330                 335     


Asn Leu Lys Ala 
            340 


<210>  6095
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  6095

Met Asp Gly Asn Asp Asn Val Thr Leu Leu Phe Ala Pro Leu Leu Arg 
1               5                   10                  15      


Asp Asn Tyr Thr Leu Ala Pro Asn Ala Ser Ser Leu Gly Pro Gly Thr 
            20                  25                  30          


Asp Leu Ala Leu Ala Pro Ala Ser Ser Ala Gly Pro Gly Pro Gly Leu 
        35                  40                  45              


Ser Leu Gly Pro Gly Pro Ser Phe Gly Phe Ser Pro Gly Pro Thr Pro 
    50                  55                  60                  


Thr Pro Glu Pro Thr Thr Ser Gly Leu Ala Gly Gly Ala Ala Ser His 
65                  70                  75                  80  


Gly Pro Ser Pro Phe Pro Arg Pro Trp Ala Pro His Ala Leu Pro Phe 
                85                  90                  95      


Trp Asp Thr Pro Leu Asn His Gly Leu Asn Val Phe Val Gly Ala Ala 
            100                 105                 110         


Leu Cys Ile Thr Met Leu Gly Leu Gly Cys Thr Val Asp Val Asn His 
        115                 120                 125             


Phe Gly Ala His Val Arg Arg Pro Val Gly Ala Leu Leu Ala Ala Leu 
    130                 135                 140                 


Cys Gln Phe Gly Leu Leu Pro Leu Leu Ala Phe Leu Leu Ala Leu Ala 
145                 150                 155                 160 


Phe Lys Leu Asp Glu Val Ala Ala Val Ala Val Leu Leu Cys Gly Cys 
                165                 170                 175     


Cys Pro Gly Gly Asn Leu Ser Asn Leu Met Ser Leu Leu Val Asp Gly 
            180                 185                 190         


Asp Met Asn Leu Ser Ile Ile Met Thr Ile Ser Ser Thr Leu Leu Ala 
        195                 200                 205             


Leu Val Leu Met Pro Leu Cys Leu Trp Ile Tyr Ser Trp Ala Trp Ile 
    210                 215                 220                 


Asn Thr Pro Ile Val Gln Leu Leu Pro Leu Gly Thr Val Thr Leu Thr 
225                 230                 235                 240 


Leu Cys Ser Thr Leu Ile Pro Ile Gly Leu Gly Val Phe Ile Arg Tyr 
                245                 250                 255     


Lys Tyr Ser Arg Val Ala Asp Tyr Ile Val Lys Val Ser Leu Trp Ser 
            260                 265                 270         


Leu Leu Val Thr Leu Val Val Leu Phe Ile Met Thr Gly Thr Met Leu 
        275                 280                 285             


Gly Pro Glu Leu Leu Ala Ser Ile Pro Ala Ala Val Tyr Val Ile Ala 
    290                 295                 300                 


Ile Phe Met Pro Leu Ala Gly Tyr Ala Ser Gly Tyr Gly Leu Ala Thr 
305                 310                 315                 320 


Leu Phe His Leu Pro Pro Asn Cys Lys Arg Thr Val Cys Leu Glu Thr 
                325                 330                 335     


Gly Ser Gln Asn Val Gln Leu Cys Thr Ala Ile Leu Lys Leu Ala Phe 
            340                 345                 350         


Pro Pro Gln Phe Ile Gly Ser Met Tyr Met Phe Pro Leu Leu Tyr Ala 
        355                 360                 365             


Leu Phe Gln Ser Ala Glu Ala Gly Ile Phe Val Leu Ile Tyr Lys Met 
    370                 375                 380                 


Tyr Gly Ser Glu Met Leu His Lys Arg Asp Pro Leu Asp Glu Asp Glu 
385                 390                 395                 400 


Asp Thr Asp Ile Ser Tyr Lys Lys Leu Lys Glu Glu Glu Met Ala Asp 
                405                 410                 415     


Thr Ser Tyr Gly Thr Val Lys Ala Glu Asn Ile Ile Met Met Glu Thr 
            420                 425                 430         


Ala Gln Thr Ser Leu 
        435         


<210>  6096
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  6096

Met Gln Ala Pro Arg Ala Ala Leu Val Phe Ala Leu Val Ile Ala Leu 
1               5                   10                  15      


Val Pro Val Gly Arg Gly Asn Tyr Glu Glu Leu Glu Asn Ser Gly Asp 
            20                  25                  30          


Thr Thr Val Glu Ser Glu Arg Pro Asn Lys Val Thr Ile Pro Ser Thr 
        35                  40                  45              


Phe Ala Ala Val Thr Ile Lys Glu Thr Leu Asn Ala Asn Ile Asn Ser 
    50                  55                  60                  


Thr Asn Phe Ala Pro Asp Glu Asn Gln Leu Glu Phe Ile Leu Met Val 
65                  70                  75                  80  


Leu Ile Pro Leu Ile Leu Leu Val Leu Leu Leu Leu Ser Val Val Phe 
                85                  90                  95      


Leu Ala Thr Tyr Tyr Lys Arg Lys Arg Thr Lys Gln Glu Pro Ser Ser 
            100                 105                 110         


Gln Gly Ser Gln Ser Ala Leu Gln Thr Tyr Glu Leu Gly Ser Glu Asn 
        115                 120                 125             


Val Lys Val Pro Ile Phe Glu Glu Asp Thr Pro Ser Val Met Glu Ile 
    130                 135                 140                 


Glu Met Glu Glu Leu Asp Lys Trp Met Asn Ser Met Asn Arg Asn Ala 
145                 150                 155                 160 


Asp Phe Glu Cys Leu Pro Thr Leu Lys Glu Glu Lys Glu Ser Asn His 
                165                 170                 175     


Asn Pro Ser Asp Ser Glu Ser 
            180             


<210>  6097
<211>  602
<212>  PRT
<213>  Homo sapiens

<400>  6097

Met Arg Ala Gln Glu Asp Leu Glu Gly Arg Thr Gln His Glu Thr Thr 
1               5                   10                  15      


Arg Asp Pro Ser Thr Pro Leu Pro Thr Glu Pro Lys Phe Asp Met Leu 
            20                  25                  30          


Tyr Lys Ile Glu Asp Val Pro Pro Trp Tyr Leu Cys Ile Leu Leu Gly 
        35                  40                  45              


Phe Gln His Tyr Leu Thr Cys Phe Ser Gly Thr Ile Ala Val Pro Phe 
    50                  55                  60                  


Leu Leu Ala Glu Ala Leu Cys Val Gly His Asp Gln His Met Val Ser 
65                  70                  75                  80  


Gln Leu Ile Gly Thr Ile Phe Thr Cys Val Gly Ile Thr Thr Leu Ile 
                85                  90                  95      


Gln Thr Thr Val Gly Ile Arg Leu Pro Leu Phe Gln Ala Ser Ala Phe 
            100                 105                 110         


Ala Phe Leu Val Pro Ala Lys Ala Ile Leu Ala Leu Glu Arg Trp Lys 
        115                 120                 125             


Cys Pro Pro Glu Glu Glu Ile Tyr Gly Asn Trp Ser Leu Pro Leu Asn 
    130                 135                 140                 


Thr Ser His Ile Trp His Pro Arg Ile Arg Glu Val Gly Leu His Val 
145                 150                 155                 160 


Gln Gly Ala Ile Met Val Ser Ser Val Val Glu Val Val Ile Gly Leu 
                165                 170                 175     


Leu Gly Leu Pro Gly Ala Leu Leu Asn Tyr Ile Gly Pro Leu Thr Val 
            180                 185                 190         


Thr Pro Thr Val Ser Leu Ile Gly Leu Ser Val Phe Gln Ala Ala Gly 
        195                 200                 205             


Asp Arg Ala Gly Ser His Trp Gly Ile Ser Ala Cys Ser Ile Leu Leu 
    210                 215                 220                 


Ile Ile Leu Phe Ser Gln Tyr Leu Arg Asn Leu Thr Phe Leu Leu Pro 
225                 230                 235                 240 


Val Tyr Arg Trp Gly Lys Gly Leu Thr Leu Leu Arg Ile Gln Ile Phe 
                245                 250                 255     


Lys Met Phe Pro Ile Met Leu Ala Ile Met Thr Val Trp Leu Leu Cys 
            260                 265                 270         


Tyr Val Leu Thr Leu Thr Asp Val Leu Pro Thr Asp Pro Lys Ala Tyr 
        275                 280                 285             


Gly Phe Gln Ala Arg Thr Asp Ala Arg Gly Asp Ile Met Ala Ile Ala 
    290                 295                 300                 


Pro Trp Ile Arg Ile Pro Tyr Pro Cys Gln Trp Gly Leu Pro Thr Val 
305                 310                 315                 320 


Thr Ala Ala Ala Val Leu Gly Met Phe Ser Ala Thr Leu Ala Gly Ile 
                325                 330                 335     


Ile Glu Ser Ile Gly Asp Tyr Tyr Ala Cys Ala Arg Leu Ala Gly Ala 
            340                 345                 350         


Pro Pro Pro Pro Val His Ala Ile Asn Arg Gly Ile Phe Thr Glu Gly 
        355                 360                 365             


Ile Cys Cys Ile Ile Ala Gly Leu Leu Gly Thr Gly Asn Gly Ser Thr 
    370                 375                 380                 


Ser Ser Ser Pro Asn Ile Gly Val Leu Gly Ile Thr Lys Val Gly Ser 
385                 390                 395                 400 


Arg Arg Val Val Gln Tyr Gly Ala Ala Ile Met Leu Val Leu Gly Thr 
                405                 410                 415     


Ile Gly Lys Phe Thr Ala Leu Phe Ala Ser Leu Pro Asp Pro Ile Leu 
            420                 425                 430         


Gly Gly Met Phe Cys Thr Leu Phe Gly Met Ile Thr Ala Val Gly Leu 
        435                 440                 445             


Ser Asn Leu Gln Phe Val Asp Met Asn Ser Ser Arg Asn Leu Phe Val 
    450                 455                 460                 


Leu Gly Phe Ser Met Phe Phe Gly Leu Thr Leu Pro Asn Tyr Leu Glu 
465                 470                 475                 480 


Ser Asn Pro Gly Ala Ile Asn Thr Gly Ile Leu Glu Val Asp Gln Ile 
                485                 490                 495     


Leu Ile Val Leu Leu Thr Thr Glu Met Phe Val Gly Gly Cys Leu Ala 
            500                 505                 510         


Phe Ile Leu Asp Asn Thr Val Pro Gly Ser Pro Glu Glu Arg Gly Leu 
        515                 520                 525             


Ile Gln Trp Lys Ala Gly Ala His Ala Asn Ser Asp Met Ser Ser Ser 
    530                 535                 540                 


Leu Lys Ser Tyr Asp Phe Pro Ile Gly Met Gly Ile Val Lys Arg Ile 
545                 550                 555                 560 


Thr Phe Leu Lys Tyr Ile Pro Ile Cys Pro Val Phe Lys Gly Phe Ser 
                565                 570                 575     


Ser Ser Ser Lys Asp Gln Ile Ala Ile Pro Glu Asp Thr Pro Glu Asn 
            580                 585                 590         


Thr Glu Thr Ala Ser Val Cys Thr Lys Val 
        595                 600         


<210>  6098
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  6098

Met Ala Ala Thr Leu Gly Ser Gly Glu Arg Trp Thr Glu Ala Tyr Ile 
1               5                   10                  15      


Asp Ala Val Arg Arg Asn Lys Tyr Pro Glu Asp Thr Pro Pro Glu Ser 
            20                  25                  30          


His Asp Pro Cys Gly Cys Cys Asn Cys Met Lys Ala Gln Lys Glu Lys 
        35                  40                  45              


Lys Ser Glu Asn Glu Trp Thr Gln Thr Arg Gln Gly Glu Gly Asn Ser 
    50                  55                  60                  


Thr Tyr Ser Glu Glu Gln Leu Leu Gly Val Gln Arg Ile Lys Lys Cys 
65                  70                  75                  80  


Arg Asn Tyr Tyr Glu Ile Leu Gly Val Ser Arg Asp Ala Ser Asp Glu 
                85                  90                  95      


Glu Leu Lys Lys Ala Tyr Arg Lys Leu Ala Leu Lys Phe His Pro Asp 
            100                 105                 110         


Lys Asn Cys Ala Pro Gly Ala Thr Asp Ala Phe Lys Ala Ile Gly Asn 
        115                 120                 125             


Ala Phe Ala Val Leu Ser Asn Pro Asp Lys Arg Leu Arg Tyr Asp Glu 
    130                 135                 140                 


Tyr Gly Asp Glu Gln Val Thr Phe Thr Ala Pro Arg Ala Arg Pro Tyr 
145                 150                 155                 160 


Asn Tyr Tyr Arg Asp Phe Glu Ala Asp Ile Thr Pro Glu Glu Leu Phe 
                165                 170                 175     


Asn Val Phe Phe Gly Gly His Phe Pro Thr Gly Asn Ile His Met Phe 
            180                 185                 190         


Ser Asn Val Thr Asp Asp Thr Tyr Tyr Tyr Arg Arg Arg His Arg His 
        195                 200                 205             


Glu Arg Thr Gln Thr Gln Lys Glu Glu Glu Glu Glu Lys Pro Gln Thr 
    210                 215                 220                 


Thr Tyr Ser Ala Phe Ile Gln Leu Leu Pro Val Leu Val Ile Val Ile 
225                 230                 235                 240 


Ile Ser Val Ile Thr Gln Leu Leu Ala Thr Asn Pro Pro Tyr Ser Leu 
                245                 250                 255     


Phe Tyr Lys Ser Thr Leu Gly Tyr Thr Ile Ser Arg Glu Thr Gln Asn 
            260                 265                 270         


Leu Gln Val Pro Tyr Phe Val Asp Lys Asn Phe Asp Lys Ala Tyr Arg 
        275                 280                 285             


Gly Ala Ser Leu His Asp Leu Glu Lys Thr Ile Glu Lys Asp Tyr Ile 
    290                 295                 300                 


Asp Tyr Ile Gln Thr Ser Cys Trp Lys Glu Lys Gln Gln Lys Ser Glu 
305                 310                 315                 320 


Leu Thr Asn Leu Ala Gly Leu Tyr Arg Asp Glu Arg Leu Lys Gln Lys 
                325                 330                 335     


Ala Glu Ser Leu Lys Leu Glu Asn Cys Glu Lys Leu Ser Lys Leu Ile 
            340                 345                 350         


Gly Leu Arg Arg Gly Gly 
        355             


<210>  6099
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  6099

Met Ser Lys Ser Cys Gly Asn Asn Leu Ala Ala Ile Ser Val Gly Ile 
1               5                   10                  15      


Ser Leu Leu Leu Leu Leu Val Val Cys Gly Ile Gly Cys Val Trp His 
            20                  25                  30          


Trp Lys His Arg Val Ala Thr Arg Phe Thr Leu Pro Arg Phe Leu Gln 
        35                  40                  45              


Arg Arg Ser Ser Arg Arg Lys Val Cys Thr Lys Thr Phe Leu Gly Pro 
    50                  55                  60                  


Arg Ile Ile Gly Leu Arg His Glu Ile Ser Val Glu Thr Gln Asp His 
65                  70                  75                  80  


Lys Ser Ala Val Arg Gly Asn Asn Thr His Asp Asn Tyr Glu Asn Val 
                85                  90                  95      


Glu Ala Gly Pro Pro Lys Ala Lys Gly Lys Thr Asp Lys Glu Leu Tyr 
            100                 105                 110         


Glu Asn Thr Gly Gln Ser Asn Phe Glu Glu His Ile Tyr Gly Asn Glu 
        115                 120                 125             


Thr Ser Ser Asp Tyr Tyr Asn Phe Gln Lys Pro Arg Pro Ser Glu Val 
    130                 135                 140                 


Pro Gln Asp Glu Asp Ile Tyr Ile Leu Pro Asp Ser Tyr 
145                 150                 155         


<210>  6100
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  6100

Met Leu Ser Glu Ser Ser Ser Phe Leu Lys Gly Val Met Leu Gly Ser 
1               5                   10                  15      


Ile Phe Cys Ala Leu Ile Thr Met Leu Gly His Ile Arg Ile Gly His 
            20                  25                  30          


Gly Asn Arg Met His His His Glu His His His Leu Gln Ala Pro Asn 
        35                  40                  45              


Lys Glu Asp Ile Leu Lys Ile Ser Glu Asp Glu Arg Met Glu Leu Ser 
    50                  55                  60                  


Lys Ser Phe Arg Val Tyr Cys Ile Ile Leu Val Lys Pro Lys Asp Val 
65                  70                  75                  80  


Ser Leu Trp Ala Ala Val Lys Glu Thr Trp Thr Lys His Cys Asp Lys 
                85                  90                  95      


Ala Glu Phe Phe Ser Ser Glu Asn Val Lys Val Phe Glu Ser Ile Asn 
            100                 105                 110         


Met Asp Thr Asn Asp Met Trp Leu Met Met Arg Lys Ala Tyr Lys Tyr 
        115                 120                 125             


Ala Phe Asp Lys Tyr Arg Asp Gln Tyr Asn Trp Phe Phe Leu Ala Arg 
    130                 135                 140                 


Pro Thr Thr Phe Ala Ile Ile Glu Asn Leu Lys Tyr Phe Leu Leu Lys 
145                 150                 155                 160 


Lys Asp Pro Ser Gln Pro Phe Tyr Leu Gly His Thr Ile Lys Ser Gly 
                165                 170                 175     


Asp Leu Glu Tyr Val Gly Met Glu Gly Gly Ile Val Leu Ser Val Glu 
            180                 185                 190         


Ser Met Lys Arg Leu Asn Ser Leu Leu Asn Ile Pro Glu Lys Cys Pro 
        195                 200                 205             


Glu Gln Gly Gly Met Ile Trp Lys Ile Ser Glu Asp Lys Gln Leu Ala 
    210                 215                 220                 


Val Cys Leu Lys Tyr Ala Gly Val Phe Ala Glu Asn Ala Glu Asp Ala 
225                 230                 235                 240 


Asp Gly Lys Asp Val Phe Asn Thr Lys Ser Val Gly Leu Ser Ile Lys 
                245                 250                 255     


Glu Ala Met Thr Tyr His Pro Asn Gln Val Val Glu Gly Cys Cys Ser 
            260                 265                 270         


Asp Met Ala Val Thr Phe Asn Gly Leu Thr Pro Asn Gln Met His Val 
        275                 280                 285             


Met Met Tyr Gly Val Tyr Arg Leu Arg Ala Phe Gly His Ile Phe Asn 
    290                 295                 300                 


Asp Ala Leu Val Phe Leu Pro Pro Asn Gly Ser Asp Asn Asp 
305                 310                 315             


<210>  6101
<211>  719
<212>  PRT
<213>  Homo sapiens

<400>  6101

Met Asn Asp Thr Glu Lys Pro Ala Asp Thr Pro Ser Glu Glu Glu Asp 
1               5                   10                  15      


Phe Gly Asp Pro Arg Thr Tyr Asp Pro Asp Phe Lys Gly Pro Val Ala 
            20                  25                  30          


Asn Arg Ser Cys Thr Asp Val Leu Cys Cys Met Ile Phe Leu Leu Cys 
        35                  40                  45              


Ile Ile Gly Tyr Ile Val Leu Gly Leu Val Ala Trp Val His Gly Asp 
    50                  55                  60                  


Pro Arg Arg Ala Ala Tyr Pro Thr Asp Ser Gln Gly His Phe Cys Gly 
65                  70                  75                  80  


Gln Lys Gly Thr Pro Asn Glu Asn Lys Thr Ile Leu Phe Tyr Phe Asn 
                85                  90                  95      


Leu Leu Arg Cys Thr Ser Pro Ser Val Leu Leu Asn Leu Gln Cys Pro 
            100                 105                 110         


Thr Thr Gln Ile Cys Val Ser Lys Cys Pro Glu Lys Phe Leu Thr Tyr 
        115                 120                 125             


Val Glu Met Gln Leu Leu Tyr Thr Lys Asp Lys Ser Tyr Trp Glu Asp 
    130                 135                 140                 


Tyr Arg Gln Phe Cys Lys Thr Thr Ala Lys Pro Val Lys Ser Leu Thr 
145                 150                 155                 160 


Gln Leu Leu Leu Asp Asp Asp Cys Pro Thr Ala Ile Phe Pro Ser Lys 
                165                 170                 175     


Pro Phe Leu Gln Arg Cys Phe Pro Asp Phe Ser Thr Lys Asn Gly Thr 
            180                 185                 190         


Leu Thr Ile Gly Ser Lys Met Met Phe Gln Asp Gly Asn Gly Gly Thr 
        195                 200                 205             


Arg Ser Val Val Glu Leu Gly Ile Ala Ala Asn Gly Ile Asn Lys Leu 
    210                 215                 220                 


Leu Asp Ala Lys Ser Leu Gly Leu Lys Val Phe Glu Asp Tyr Ala Arg 
225                 230                 235                 240 


Thr Trp Tyr Trp Ile Leu Ile Gly Leu Thr Ile Ala Met Val Leu Ser 
                245                 250                 255     


Trp Ile Phe Leu Ile Leu Leu Arg Phe Ile Ala Gly Cys Leu Phe Trp 
            260                 265                 270         


Val Phe Met Ile Gly Val Ile Gly Ile Ile Gly Tyr Gly Ile Trp His 
        275                 280                 285             


Cys Tyr Gln Gln Tyr Thr Asn Leu Gln Glu Arg Pro Ser Ser Val Leu 
    290                 295                 300                 


Thr Ile Tyr Asp Ile Gly Ile Gln Thr Asn Ile Ser Met Tyr Phe Glu 
305                 310                 315                 320 


Leu Gln Gln Thr Trp Phe Thr Phe Met Ile Ile Leu Cys Ile Ile Glu 
                325                 330                 335     


Val Ile Val Ile Leu Met Leu Ile Phe Leu Arg Asn Arg Ile Arg Val 
            340                 345                 350         


Ala Ile Ile Leu Leu Lys Glu Gly Ser Lys Ala Ile Gly Tyr Val Pro 
        355                 360                 365             


Ser Thr Leu Val Tyr Pro Ala Leu Thr Phe Ile Leu Leu Ser Ile Cys 
    370                 375                 380                 


Ile Cys Tyr Trp Val Val Thr Ala Val Phe Leu Ala Thr Ser Gly Val 
385                 390                 395                 400 


Pro Val Tyr Lys Val Ile Ala Pro Gly Gly His Cys Ile His Glu Asn 
                405                 410                 415     


Gln Thr Cys Asp Pro Glu Ile Phe Asn Thr Thr Glu Ile Ala Lys Ala 
            420                 425                 430         


Cys Pro Gly Ala Leu Cys Asn Phe Ala Phe Tyr Gly Gly Lys Ser Leu 
        435                 440                 445             


Tyr His Gln Tyr Ile Pro Thr Phe His Val Tyr Asn Leu Phe Val Phe 
    450                 455                 460                 


Leu Trp Leu Ile Asn Phe Val Ile Ala Leu Gly Gln Cys Ala Leu Ala 
465                 470                 475                 480 


Gly Ala Phe Ala Thr Tyr Tyr Trp Ala Met Lys Lys Pro Asp Asp Ile 
                485                 490                 495     


Pro Arg Tyr Pro Leu Phe Thr Ala Phe Gly Arg Ala Ile Arg Tyr His 
            500                 505                 510         


Thr Gly Ser Leu Ala Phe Gly Ser Leu Ile Ile Ala Leu Ile Gln Met 
        515                 520                 525             


Phe Lys Ile Val Leu Glu Tyr Leu Asp His Arg Leu Lys Arg Thr Gln 
    530                 535                 540                 


Asn Thr Leu Ser Lys Phe Leu Gln Cys Cys Leu Arg Cys Cys Phe Trp 
545                 550                 555                 560 


Cys Leu Glu Asn Ala Ile Lys Phe Leu Asn Arg Asn Ala Tyr Ile Met 
                565                 570                 575     


Ile Ala Ile Tyr Gly Arg Asn Phe Cys Arg Ser Ala Lys Asp Ala Phe 
            580                 585                 590         


Asn Leu Leu Met Arg Asn Val Leu Lys Val Ala Val Thr Asp Glu Val 
        595                 600                 605             


Thr Tyr Phe Val Leu Phe Leu Gly Lys Leu Leu Val Ala Gly Ser Ile 
    610                 615                 620                 


Gly Val Leu Ala Phe Leu Phe Phe Thr Gln Arg Leu Pro Val Ile Ala 
625                 630                 635                 640 


Gln Gly Pro Ala Ser Leu Asn Tyr Tyr Trp Val Pro Leu Leu Thr Val 
                645                 650                 655     


Ile Phe Gly Ser Tyr Leu Ile Ala His Gly Phe Phe Ser Val Tyr Ala 
            660                 665                 670         


Met Cys Val Glu Thr Ile Phe Ile Cys Phe Cys Glu Asp Leu Glu Arg 
        675                 680                 685             


Asn Asp Gly Ser Thr Glu Lys Pro Tyr Phe Val Thr Pro Asn Leu His 
    690                 695                 700                 


Gly Ile Leu Ile Lys Lys Gln Leu Val Pro Gln Lys Gln Lys Glu 
705                 710                 715                 


<210>  6102
<211>  5058
<212>  PRT
<213>  Homo sapiens

<400>  6102

Met Gly His Ala Gly Cys Gln Phe Lys Ala Leu Leu Trp Lys Asn Trp 
1               5                   10                  15      


Leu Cys Arg Leu Arg Asn Pro Val Leu Phe Leu Ala Glu Phe Phe Trp 
            20                  25                  30          


Pro Cys Ile Leu Phe Val Ile Leu Thr Val Leu Arg Phe Gln Glu Pro 
        35                  40                  45              


Pro Arg Tyr Arg Asp Ile Cys Tyr Leu Gln Pro Arg Asp Leu Pro Ser 
    50                  55                  60                  


Cys Gly Val Ile Pro Phe Val Gln Ser Leu Leu Cys Asn Thr Gly Ser 
65                  70                  75                  80  


Arg Cys Arg Asn Phe Ser Tyr Glu Gly Ser Met Glu His His Phe Arg 
                85                  90                  95      


Leu Ser Arg Phe Gln Thr Ala Ala Asp Pro Lys Lys Val Asn Asn Leu 
            100                 105                 110         


Ala Phe Leu Lys Glu Ile Gln Asp Leu Ala Glu Glu Ile His Gly Met 
        115                 120                 125             


Met Asp Lys Ala Lys Asn Leu Lys Arg Leu Trp Val Glu Arg Ser Asn 
    130                 135                 140                 


Thr Pro Asp Ser Ser Tyr Gly Ser Ser Phe Phe Thr Met Asp Leu Asn 
145                 150                 155                 160 


Lys Thr Glu Glu Val Ile Leu Lys Leu Glu Ser Leu His Gln Gln Pro 
                165                 170                 175     


His Ile Trp Asp Phe Leu Leu Leu Leu Pro Arg Leu His Thr Ser His 
            180                 185                 190         


Asp His Val Glu Asp Gly Met Asp Val Ala Val Asn Leu Leu Gln Thr 
        195                 200                 205             


Ile Leu Asn Ser Leu Ile Ser Leu Glu Asp Leu Asp Trp Leu Pro Leu 
    210                 215                 220                 


Asn Gln Thr Phe Ser Gln Val Ser Glu Leu Val Leu Asn Val Thr Ile 
225                 230                 235                 240 


Ser Thr Leu Thr Phe Leu Gln Gln His Gly Val Ala Val Thr Glu Pro 
                245                 250                 255     


Val Tyr His Leu Ser Met Gln Asn Ile Val Trp Asp Pro Gln Lys Val 
            260                 265                 270         


Gln Tyr Asp Leu Lys Ser Gln Phe Gly Phe Asp Asp Leu His Thr Glu 
        275                 280                 285             


Gln Ile Leu Asn Ser Ser Ala Glu Leu Lys Glu Ile Pro Thr Asp Thr 
    290                 295                 300                 


Ser Leu Glu Lys Met Val Cys Ser Val Leu Ser Ser Thr Ser Glu Asp 
305                 310                 315                 320 


Glu Ala Glu Lys Trp Gly His Val Gly Gly Cys His Pro Lys Trp Ser 
                325                 330                 335     


Glu Ala Lys Asn Tyr Leu Val His Ala Val Ser Trp Leu Arg Val Tyr 
            340                 345                 350         


Gln Gln Val Phe Val Gln Trp Gln Gln Gly Ser Leu Leu Gln Lys Thr 
        355                 360                 365             


Leu Thr Gly Met Gly His Ser Leu Glu Ala Leu Arg Asn Gln Phe Glu 
    370                 375                 380                 


Glu Glu Ser Lys Pro Trp Lys Val Val Glu Ala Leu His Thr Ala Leu 
385                 390                 395                 400 


Leu Leu Leu Asn Asp Ser Leu Ser Ala Asp Gly Pro Lys Asp Asn His 
                405                 410                 415     


Thr Phe Pro Lys Ile Leu Gln His Leu Trp Lys Leu Gln Ser Leu Leu 
            420                 425                 430         


Gln Asn Leu Pro Gln Trp Pro Ala Leu Lys Arg Phe Leu Gln Leu Asp 
        435                 440                 445             


Gly Ala Leu Arg Asn Ala Ile Ala Gln Asn Leu His Phe Val Gln Glu 
    450                 455                 460                 


Val Leu Ile Cys Leu Glu Thr Ser Ala Asn Asp Phe Lys Trp Phe Glu 
465                 470                 475                 480 


Leu Asn Gln Leu Lys Leu Glu Lys Asp Val Phe Phe Trp Glu Leu Lys 
                485                 490                 495     


Gln Met Leu Ala Lys Asn Ala Val Cys Pro Asn Gly Arg Phe Ser Glu 
            500                 505                 510         


Lys Glu Val Phe Leu Pro Pro Gly Asn Ser Ser Ile Trp Gly Gly Leu 
        515                 520                 525             


Gln Gly Leu Leu Cys Tyr Cys Asn Ser Ser Glu Thr Ser Val Leu Asn 
    530                 535                 540                 


Lys Leu Leu Gly Ser Val Glu Asp Ala Asp Arg Ile Leu Gln Glu Val 
545                 550                 555                 560 


Ile Thr Trp His Lys Asn Met Ser Val Leu Ile Pro Glu Glu Tyr Leu 
                565                 570                 575     


Asp Trp Gln Glu Leu Glu Met Gln Leu Ser Glu Ala Ser Leu Ser Cys 
            580                 585                 590         


Thr Arg Leu Phe Leu Leu Leu Gly Ala Asp Pro Ser Pro Glu Asn Asp 
        595                 600                 605             


Val Phe Ser Ser Asp Cys Lys His Gln Leu Val Ser Thr Val Ile Phe 
    610                 615                 620                 


His Thr Leu Glu Lys Thr Gln Phe Phe Leu Glu Gln Ala Tyr Tyr Trp 
625                 630                 635                 640 


Lys Ala Phe Lys Lys Phe Ile Arg Lys Thr Cys Glu Val Ala Gln Tyr 
                645                 650                 655     


Val Asn Met Gln Glu Ser Phe Gln Asn Arg Leu Leu Ala Phe Pro Glu 
            660                 665                 670         


Glu Ser Pro Cys Phe Glu Glu Asn Met Asp Trp Lys Met Ile Ser Asp 
        675                 680                 685             


Asn Tyr Phe Gln Phe Leu Asn Asn Leu Leu Lys Ser Pro Thr Ala Ser 
    690                 695                 700                 


Ile Ser Arg Ala Leu Asn Phe Thr Lys His Leu Leu Met Met Glu Lys 
705                 710                 715                 720 


Lys Leu His Thr Leu Glu Asp Glu Gln Met Asn Phe Leu Leu Ser Phe 
                725                 730                 735     


Val Glu Phe Phe Glu Lys Leu Leu Leu Pro Asn Leu Phe Asp Ser Ser 
            740                 745                 750         


Ile Val Pro Ser Phe His Ser Leu Pro Ser Leu Thr Glu Asp Ile Leu 
        755                 760                 765             


Asn Ile Ser Ser Leu Trp Thr Asn His Leu Lys Ser Leu Lys Arg Asp 
    770                 775                 780                 


Pro Ser Ala Thr Asp Ala Gln Lys Leu Leu Glu Phe Gly Asn Glu Val 
785                 790                 795                 800 


Ile Trp Lys Met Gln Thr Leu Gly Ser His Trp Ile Arg Lys Glu Pro 
                805                 810                 815     


Lys Asn Leu Leu Arg Phe Ile Glu Leu Ile Leu Phe Glu Ile Asn Pro 
            820                 825                 830         


Lys Leu Leu Glu Leu Trp Ala Tyr Gly Ile Ser Lys Gly Lys Arg Ala 
        835                 840                 845             


Lys Leu Glu Asn Phe Phe Thr Leu Leu Asn Phe Ser Val Pro Glu Asn 
    850                 855                 860                 


Glu Ile Leu Ser Thr Ser Phe Asn Phe Ser Gln Leu Phe His Ser Asp 
865                 870                 875                 880 


Trp Pro Lys Ser Pro Ala Met Asn Ile Asp Phe Val Arg Leu Ser Glu 
                885                 890                 895     


Ala Ile Ile Thr Ser Leu His Glu Phe Gly Phe Leu Glu Gln Glu Gln 
            900                 905                 910         


Ile Ser Glu Ala Leu Asn Thr Val Tyr Ala Ile Arg Asn Ala Ser Asp 
        915                 920                 925             


Leu Phe Ser Ala Leu Ser Glu Pro Gln Lys Gln Glu Val Asp Lys Ile 
    930                 935                 940                 


Leu Thr His Ile His Leu Asn Val Phe Gln Asp Lys Asp Ser Ala Leu 
945                 950                 955                 960 


Leu Leu Gln Ile Tyr Ser Ser Phe Tyr Arg Tyr Ile Tyr Glu Leu Leu 
                965                 970                 975     


Asn Ile Gln Ser Arg Gly Ser Ser Leu Thr Phe Leu Thr Gln Ile Ser 
            980                 985                 990         


Lys His Ile Leu Asp Ile Ile Lys  Gln Phe Asn Phe Gln  Asn Ile Ser 
        995                 1000                 1005             


Lys Ala  Phe Ala Phe Leu Phe  Lys Thr Ala Glu Val  Leu Gly Gly 
    1010                 1015                 1020             


Ile Ser  Asn Val Ser Tyr Cys  Gln Gln Leu Leu Ser  Ile Phe Asn 
    1025                 1030                 1035             


Phe Leu  Glu Leu Gln Ala Gln  Ser Phe Met Ser Thr  Glu Gly Gln 
    1040                 1045                 1050             


Glu Leu  Glu Val Ile His Thr  Thr Leu Thr Gly Leu  Lys Gln Leu 
    1055                 1060                 1065             


Leu Ile  Ile Asp Glu Asp Phe  Arg Ile Ser Leu Phe  Gln Tyr Met 
    1070                 1075                 1080             


Ser Gln  Phe Phe Asn Ser Ser  Val Glu Asp Leu Leu  Asp Asn Lys 
    1085                 1090                 1095             


Cys Leu  Ile Ser Asp Asn Lys  His Ile Ser Ser Val  Asn Tyr Ser 
    1100                 1105                 1110             


Thr Ser  Glu Glu Ser Ser Phe  Val Phe Pro Leu Ala  Gln Ile Phe 
    1115                 1120                 1125             


Ser Asn  Leu Ser Ala Asn Val  Ser Val Phe Asn Lys  Phe Met Ser 
    1130                 1135                 1140             


Ile His  Cys Thr Val Ser Trp  Leu Gln Met Trp Thr  Glu Ile Trp 
    1145                 1150                 1155             


Glu Thr  Ile Ser Gln Leu Phe  Lys Phe Asp Met Asn  Val Phe Thr 
    1160                 1165                 1170             


Ser Leu  His His Gly Phe Thr  Gln Leu Leu Asp Glu  Leu Glu Asp 
    1175                 1180                 1185             


Asp Val  Lys Val Ser Lys Ser  Cys Gln Gly Ile Leu  Pro Thr His 
    1190                 1195                 1200             


Asn Val  Ala Arg Leu Ile Leu  Asn Leu Phe Lys Asn  Val Thr Gln 
    1205                 1210                 1215             


Ala Asn  Asp Phe His Asn Trp  Glu Asp Phe Leu Asp  Leu Arg Asp 
    1220                 1225                 1230             


Phe Leu  Val Ala Leu Gly Asn  Ala Leu Val Ser Val  Lys Lys Leu 
    1235                 1240                 1245             


Asn Leu  Glu Gln Val Glu Lys  Ser Leu Phe Thr Met  Glu Ala Ala 
    1250                 1255                 1260             


Leu His  Gln Leu Lys Thr Phe  Pro Phe Asn Glu Ser  Thr Ser Arg 
    1265                 1270                 1275             


Glu Phe  Leu Asn Ser Leu Leu  Glu Val Phe Ile Glu  Phe Ser Ser 
    1280                 1285                 1290             


Thr Ser  Glu Tyr Ile Val Arg  Asn Leu Asp Ser Ile  Asn Asp Phe 
    1295                 1300                 1305             


Leu Ser  Asn Asn Leu Thr Asn  Tyr Gly Glu Lys Phe  Glu Asn Ile 
    1310                 1315                 1320             


Ile Thr  Glu Leu Arg Glu Ala  Ile Val Phe Leu Arg  Asn Val Ser 
    1325                 1330                 1335             


His Asp  Arg Asp Leu Phe Ser  Cys Ala Asp Ile Phe  Gln Asn Val 
    1340                 1345                 1350             


Thr Glu  Cys Ile Leu Glu Asp  Gly Phe Leu Tyr Val  Asn Thr Ser 
    1355                 1360                 1365             


Gln Arg  Met Leu Arg Ile Leu  Asp Thr Leu Asn Ser  Thr Phe Ser 
    1370                 1375                 1380             


Ser Glu  Asn Thr Ile Ser Ser  Leu Lys Gly Cys Ile  Val Trp Leu 
    1385                 1390                 1395             


Asp Val  Ile Asn His Leu Tyr  Leu Leu Ser Asn Ser  Ser Phe Ser 
    1400                 1405                 1410             


Gln Gly  His Leu Gln Asn Ile  Leu Gly Asn Phe Arg  Asp Ile Glu 
    1415                 1420                 1425             


Asn Lys  Met Asn Ser Ile Leu  Lys Ile Val Thr Trp  Val Leu Asn 
    1430                 1435                 1440             


Ile Lys  Lys Pro Leu Cys Ser  Ser Asn Gly Ser His  Ile Asn Cys 
    1445                 1450                 1455             


Val Asn  Ile Tyr Leu Lys Asp  Val Thr Asp Phe Leu  Asn Ile Val 
    1460                 1465                 1470             


Leu Thr  Thr Val Phe Glu Lys  Glu Lys Lys Pro Lys  Phe Glu Ile 
    1475                 1480                 1485             


Leu Leu  Ala Leu Leu Asn Asp  Ser Thr Lys Gln Val  Arg Met Ser 
    1490                 1495                 1500             


Ile Asn  Asn Leu Thr Thr Asp  Phe Asp Phe Ala Ser  Gln Ser Asn 
    1505                 1510                 1515             


Trp Arg  Tyr Phe Thr Glu Leu  Ile Leu Arg Pro Ile  Glu Met Ser 
    1520                 1525                 1530             


Asp Glu  Ile Pro Asn Gln Phe  Gln Asn Ile Trp Leu  His Leu Ile 
    1535                 1540                 1545             


Thr Leu  Gly Lys Glu Phe Gln  Lys Leu Val Lys Gly  Ile Tyr Phe 
    1550                 1555                 1560             


Asn Ile  Leu Glu Asn Asn Ser  Ser Ser Lys Thr Glu  Asn Leu Leu 
    1565                 1570                 1575             


Asn Ile  Phe Ala Thr Ser Pro  Lys Glu Lys Asp Val  Asn Ser Val 
    1580                 1585                 1590             


Gly Asn  Ser Ile Tyr His Leu  Ala Ser Tyr Leu Ala  Phe Ser Leu 
    1595                 1600                 1605             


Ser His  Asp Leu Gln Asn Ser  Pro Lys Ile Ile Ile  Ser Pro Glu 
    1610                 1615                 1620             


Ile Met  Lys Ala Thr Gly Leu  Gly Ile Gln Leu Ile  Arg Asp Val 
    1625                 1630                 1635             


Phe Asn  Ser Leu Met Pro Val  Val His His Thr Ser  Pro Gln Asn 
    1640                 1645                 1650             


Ala Gly  Tyr Met Gln Ala Leu  Lys Lys Val Thr Ser  Val Met Arg 
    1655                 1660                 1665             


Thr Leu  Lys Lys Ala Asp Ile  Asp Leu Leu Val Asp  Gln Leu Glu 
    1670                 1675                 1680             


Gln Val  Ser Val Asn Leu Met  Asp Phe Phe Lys Asn  Ile Ser Ser 
    1685                 1690                 1695             


Val Gly  Thr Gly Asn Leu Val  Val Asn Leu Leu Val  Gly Leu Met 
    1700                 1705                 1710             


Glu Lys  Phe Ala Asp Ser Ser  His Ser Trp Asn Val  Asn His Leu 
    1715                 1720                 1725             


Leu Gln  Leu Ser Arg Leu Phe  Pro Lys Asp Val Val  Asp Ala Val 
    1730                 1735                 1740             


Ile Asp  Val Tyr Tyr Val Leu  Pro His Ala Val Arg  Leu Leu Gln 
    1745                 1750                 1755             


Gly Val  Pro Gly Lys Asn Ile  Thr Glu Gly Leu Lys  Asp Val Tyr 
    1760                 1765                 1770             


Ser Phe  Thr Leu Leu His Gly  Ile Thr Ile Ser Asn  Ile Thr Lys 
    1775                 1780                 1785             


Glu Asp  Phe Ala Ile Val Ile  Lys Ile Leu Leu Asp  Thr Ile Glu 
    1790                 1795                 1800             


Leu Val  Ser Asp Lys Pro Asp  Ile Ile Ser Glu Ala  Leu Ala Cys 
    1805                 1810                 1815             


Phe Pro  Val Val Trp Cys Trp  Asn His Thr Asn Ser  Gly Phe Arg 
    1820                 1825                 1830             


Gln Asn  Ser Lys Ile Asp Pro  Cys Asn Val His Gly  Leu Met Ser 
    1835                 1840                 1845             


Ser Ser  Phe Tyr Gly Lys Val  Ala Ser Ile Leu Asp  His Phe His 
    1850                 1855                 1860             


Leu Ser  Pro Gln Gly Glu Asp  Ser Pro Cys Ser Asn  Glu Ser Ser 
    1865                 1870                 1875             


Arg Met  Glu Ile Thr Arg Lys  Val Val Cys Ile Ile  His Glu Leu 
    1880                 1885                 1890             


Val Asp  Trp Asn Ser Ile Leu  Leu Glu Leu Ser Glu  Val Phe His 
    1895                 1900                 1905             


Val Asn  Ile Ser Leu Val Lys  Thr Val Gln Lys Phe  Trp His Lys 
    1910                 1915                 1920             


Ile Leu  Pro Phe Val Pro Pro  Ser Ile Asn Gln Thr  Arg Asp Ser 
    1925                 1930                 1935             


Ile Ser  Glu Leu Cys Pro Ser  Gly Ser Ile Lys Gln  Val Ala Leu 
    1940                 1945                 1950             


Gln Ile  Ile Glu Lys Leu Lys  Asn Val Asn Phe Thr  Lys Val Thr 
    1955                 1960                 1965             


Ser Gly  Glu Asn Ile Leu Asp  Lys Leu Ser Ser Leu  Asn Lys Ile 
    1970                 1975                 1980             


Leu Asn  Ile Asn Glu Asp Thr  Glu Thr Ser Val Gln  Asn Ile Ile 
    1985                 1990                 1995             


Ser Ser  Asn Leu Glu Arg Thr  Val Gln Leu Ile Ser  Glu Asp Trp 
    2000                 2005                 2010             


Ser Leu  Glu Lys Ser Thr His  Asn Leu Leu Ser Leu  Phe Met Met 
    2015                 2020                 2025             


Leu Gln  Asn Ala Asn Val Thr  Gly Ser Ser Leu Glu  Ala Leu Ser 
    2030                 2035                 2040             


Ser Phe  Ile Glu Lys Ser Glu  Thr Pro Tyr Asn Phe  Glu Glu Leu 
    2045                 2050                 2055             


Trp Pro  Lys Phe Gln Gln Ile  Met Lys Asp Leu Thr  Gln Asp Phe 
    2060                 2065                 2070             


Arg Ile  Arg His Leu Leu Ser  Glu Met Asn Lys Gly  Ile Lys Ser 
    2075                 2080                 2085             


Ile Asn  Ser Met Ala Leu Gln  Lys Ile Thr Leu Gln  Phe Ala His 
    2090                 2095                 2100             


Phe Leu  Glu Ile Leu Asp Ser  Pro Ser Leu Lys Thr  Leu Glu Ile 
    2105                 2110                 2115             


Ile Glu  Asp Phe Leu Leu Val  Thr Lys Asn Trp Leu  Gln Glu Tyr 
    2120                 2125                 2130             


Ala Asn  Glu Asp Tyr Ser Arg  Met Ile Glu Thr Leu  Phe Ile Pro 
    2135                 2140                 2145             


Val Thr  Asn Glu Ser Ser Thr  Glu Asp Ile Ala Leu  Leu Ala Lys 
    2150                 2155                 2160             


Ala Ile  Ala Thr Phe Trp Gly  Ser Leu Lys Asn Ile  Ser Arg Ala 
    2165                 2170                 2175             


Gly Asn  Phe Asp Val Ala Phe  Leu Thr His Leu Leu  Asn Gln Glu 
    2180                 2185                 2190             


Gln Leu  Thr Asn Phe Ser Val  Val Gln Leu Leu Phe  Glu Asn Ile 
    2195                 2200                 2205             


Leu Ile  Asn Leu Ile Asn Asn  Leu Ala Gly Asn Ser  Gln Glu Ala 
    2210                 2215                 2220             


Ala Trp  Asn Leu Asn Asp Thr  Asp Leu Gln Ile Met  Asn Phe Ile 
    2225                 2230                 2235             


Asn Leu  Ile Leu Asn His Met  Gln Ser Glu Thr Ser  Arg Lys Thr 
    2240                 2245                 2250             


Val Leu  Ser Leu Arg Ser Ile  Val Asp Phe Thr Glu  Gln Phe Leu 
    2255                 2260                 2265             


Lys Thr  Phe Phe Ser Leu Phe  Leu Lys Glu Asp Ser  Glu Asn Lys 
    2270                 2275                 2280             


Ile Ser  Leu Leu Leu Lys Tyr  Phe His Lys Asp Val  Ile Ala Glu 
    2285                 2290                 2295             


Met Ser  Phe Val Pro Lys Asp  Lys Ile Leu Glu Ile  Leu Lys Leu 
    2300                 2305                 2310             


Asp Gln  Phe Leu Thr Leu Met  Ile Gln Asp Arg Leu  Met Asn Ile 
    2315                 2320                 2325             


Phe Ser  Ser Leu Lys Glu Thr  Ile Tyr His Leu Met  Lys Ser Ser 
    2330                 2335                 2340             


Phe Ile  Leu Asp Asn Gly Glu  Phe Tyr Phe Asp Thr  His Gln Gly 
    2345                 2350                 2355             


Leu Lys  Phe Met Gln Asp Leu  Phe Asn Ala Leu Leu  Arg Glu Thr 
    2360                 2365                 2370             


Ser Met  Lys Asn Lys Thr Glu  Asn Asn Ile Asp Phe  Phe Thr Val 
    2375                 2380                 2385             


Val Ser  Gln Leu Phe Phe His  Val Asn Lys Ser Glu  Asp Leu Phe 
    2390                 2395                 2400             


Lys Leu  Asn Gln Asp Leu Gly  Ser Ala Leu His Leu  Val Arg Glu 
    2405                 2410                 2415             


Cys Ser  Thr Glu Met Ala Arg  Leu Leu Asp Thr Ile  Leu His Ser 
    2420                 2425                 2430             


Pro Asn  Lys Asp Phe Tyr Ala  Leu Tyr Pro Thr Leu  Gln Glu Val 
    2435                 2440                 2445             


Ile Leu  Ala Asn Leu Thr Asp  Leu Leu Phe Phe Ile  Asn Asn Ser 
    2450                 2455                 2460             


Phe Pro  Leu Arg Asn Arg Ala  Thr Leu Glu Ile Thr  Lys Arg Leu 
    2465                 2470                 2475             


Val Gly  Ala Ile Ser Arg Ala  Ser Glu Glu Ser His  Val Leu Lys 
    2480                 2485                 2490             


Pro Leu  Leu Glu Met Ser Gly  Thr Leu Val Met Leu  Leu Asn Asp 
    2495                 2500                 2505             


Ser Ala  Asp Leu Arg Asp Leu  Ala Thr Ser Met Asp  Ser Ile Val 
    2510                 2515                 2520             


Lys Leu  Leu Lys Leu Val Lys  Lys Val Ser Gly Lys  Met Ser Thr 
    2525                 2530                 2535             


Val Phe  Lys Thr His Phe Ile  Ser Asn Thr Lys Asp  Ser Val Lys 
    2540                 2545                 2550             


Phe Phe  Asp Thr Leu Tyr Ser  Ile Met Gln Gln Ser  Val Gln Asn 
    2555                 2560                 2565             


Leu Val  Lys Glu Ile Ala Thr  Leu Lys Lys Ile Asp  His Phe Thr 
    2570                 2575                 2580             


Phe Glu  Lys Ile Asn Asp Leu  Leu Val Pro Phe Leu  Asp Leu Ala 
    2585                 2590                 2595             


Phe Glu  Met Ile Gly Val Glu  Pro Tyr Ile Ser Ser  Asn Ser Asp 
    2600                 2605                 2610             


Ile Phe  Ser Met Ser Pro Ser  Ile Leu Ser Tyr Met  Asn Gln Ser 
    2615                 2620                 2625             


Lys Asp  Phe Ser Asp Ile Leu  Glu Glu Ile Ala Glu  Phe Leu Thr 
    2630                 2635                 2640             


Ser Val  Lys Met Asn Leu Glu  Asp Met Arg Ser Leu  Ala Val Ala 
    2645                 2650                 2655             


Phe Asn  Asn Glu Thr Gln Thr  Phe Ser Met Asp Ser  Val Asn Leu 
    2660                 2665                 2670             


Arg Glu  Glu Ile Leu Gly Cys  Leu Val Pro Ile Asn  Asn Ile Thr 
    2675                 2680                 2685             


Asn Gln  Met Asp Phe Leu Tyr  Pro Asn Pro Ile Ser  Thr His Ser 
    2690                 2695                 2700             


Gly Pro  Gln Asp Ile Lys Trp  Glu Ile Ile His Glu  Val Ile Pro 
    2705                 2710                 2715             


Phe Leu  Asp Lys Ile Leu Ser  Gln Asn Ser Thr Glu  Ile Gly Ser 
    2720                 2725                 2730             


Phe Leu  Lys Met Val Ile Cys  Leu Thr Leu Glu Ala  Leu Trp Lys 
    2735                 2740                 2745             


Asn Leu  Lys Lys Asp Asn Trp  Asn Val Ser Asn Val  Leu Met Thr 
    2750                 2755                 2760             


Phe Thr  Gln His Pro Asn Asn  Leu Leu Lys Thr Ile  Glu Thr Val 
    2765                 2770                 2775             


Leu Glu  Ala Ser Ser Gly Ile  Lys Ser Asp Tyr Glu  Gly Asp Leu 
    2780                 2785                 2790             


Asn Lys  Ser Leu Tyr Phe Asp  Thr Pro Leu Ser Gln  Asn Ile Thr 
    2795                 2800                 2805             


His His  Gln Leu Glu Lys Ala  Ile His Asn Val Leu  Ser Arg Ile 
    2810                 2815                 2820             


Ala Leu  Trp Arg Lys Gly Leu  Leu Phe Asn Asn Ser  Glu Trp Ile 
    2825                 2830                 2835             


Thr Ser  Thr Arg Thr Leu Phe  Gln Pro Leu Phe Glu  Ile Phe Ile 
    2840                 2845                 2850             


Lys Ala  Thr Thr Gly Lys Asn  Val Thr Ser Glu Lys  Glu Glu Arg 
    2855                 2860                 2865             


Thr Lys  Lys Glu Met Ile Asp  Phe Pro Tyr Ser Phe  Lys Pro Phe 
    2870                 2875                 2880             


Phe Cys  Leu Glu Lys Tyr Leu  Gly Gly Leu Phe Val  Leu Thr Lys 
    2885                 2890                 2895             


Tyr Trp  Gln Gln Ile Pro Leu  Thr Asp Gln Ser Val  Val Glu Ile 
    2900                 2905                 2910             


Cys Glu  Val Phe Gln Gln Thr  Val Lys Pro Ser Glu  Ala Met Glu 
    2915                 2920                 2925             


Met Leu  Gln Lys Val Lys Met  Met Val Val Arg Val  Leu Thr Ile 
    2930                 2935                 2940             


Val Ala  Glu Asn Pro Ser Trp  Thr Lys Asp Ile Leu  Cys Ala Thr 
    2945                 2950                 2955             


Leu Ser  Cys Lys Gln Asn Gly  Ile Arg His Leu Ile  Leu Ser Ala 
    2960                 2965                 2970             


Ile Gln  Gly Val Thr Leu Ala  Gln Asp His Phe Gln  Glu Ile Glu 
    2975                 2980                 2985             


Lys Ile  Trp Ser Ser Pro Asn  Gln Leu Asn Cys Glu  Ser Leu Ser 
    2990                 2995                 3000             


Lys Asn  Leu Ser Ser Thr Leu  Glu Ser Phe Lys Ser  Ser Leu Glu 
    3005                 3010                 3015             


Asn Ala  Thr Gly Gln Asp Cys  Thr Ser Gln Pro Arg  Leu Glu Thr 
    3020                 3025                 3030             


Val Gln  Gln His Leu Tyr Met  Leu Ala Lys Ser Leu  Glu Glu Thr 
    3035                 3040                 3045             


Trp Ser  Ser Gly Asn Pro Ile  Met Thr Phe Leu Ser  Asn Phe Thr 
    3050                 3055                 3060             


Val Thr  Glu Asp Val Lys Ile  Lys Asp Leu Met Lys  Asn Ile Thr 
    3065                 3070                 3075             


Lys Leu  Thr Glu Glu Leu Arg  Ser Ser Ile Gln Ile  Ser Asn Glu 
    3080                 3085                 3090             


Thr Ile  His Ser Ile Leu Glu  Ala Asn Ile Ser His  Ser Lys Val 
    3095                 3100                 3105             


Leu Phe  Ser Ala Leu Thr Val  Ala Leu Ser Gly Lys  Cys Asp Gln 
    3110                 3115                 3120             


Glu Ile  Leu His Leu Leu Leu  Thr Phe Pro Lys Gly  Glu Lys Ser 
    3125                 3130                 3135             


Trp Ile  Ala Ala Glu Glu Leu  Cys Ser Leu Pro Gly  Ser Lys Val 
    3140                 3145                 3150             


Tyr Ser  Leu Ile Val Leu Leu  Ser Arg Asn Leu Asp  Val Arg Ala 
    3155                 3160                 3165             


Phe Ile  Tyr Lys Thr Leu Met  Pro Ser Glu Ala Asn  Gly Leu Leu 
    3170                 3175                 3180             


Asn Ser  Leu Leu Asp Ile Val  Ser Ser Leu Ser Ala  Leu Leu Ala 
    3185                 3190                 3195             


Lys Ala  Gln His Val Phe Glu  Tyr Leu Pro Glu Phe  Leu His Thr 
    3200                 3205                 3210             


Phe Lys  Ile Thr Ala Leu Leu  Glu Thr Leu Asp Phe  Gln Gln Val 
    3215                 3220                 3225             


Ser Gln  Asn Val Gln Ala Arg  Ser Ser Ala Phe Gly  Ser Phe Gln 
    3230                 3235                 3240             


Phe Val  Met Lys Met Val Cys  Lys Asp Gln Ala Ser  Phe Leu Ser 
    3245                 3250                 3255             


Asp Ser  Asn Met Phe Ile Asn  Leu Pro Arg Val Lys  Glu Leu Leu 
    3260                 3265                 3270             


Glu Asp  Asp Lys Glu Lys Phe  Asn Ile Pro Glu Asp  Ser Thr Pro 
    3275                 3280                 3285             


Phe Cys  Leu Lys Leu Tyr Gln  Glu Ile Leu Gln Leu  Pro Asn Gly 
    3290                 3295                 3300             


Ala Leu  Val Trp Thr Phe Leu  Lys Pro Ile Leu His  Gly Lys Ile 
    3305                 3310                 3315             


Leu Tyr  Thr Pro Asn Thr Pro  Glu Ile Asn Lys Val  Ile Gln Lys 
    3320                 3325                 3330             


Ala Asn  Tyr Thr Phe Tyr Ile  Val Asp Lys Leu Lys  Thr Leu Ser 
    3335                 3340                 3345             


Glu Thr  Leu Leu Glu Met Ser  Ser Leu Phe Gln Arg  Ser Gly Ser 
    3350                 3355                 3360             


Gly Gln  Met Phe Asn Gln Leu  Gln Glu Ala Leu Arg  Asn Lys Phe 
    3365                 3370                 3375             


Val Arg  Asn Phe Val Glu Asn  Gln Leu His Ile Asp  Val Asp Lys 
    3380                 3385                 3390             


Leu Thr  Glu Lys Leu Gln Thr  Tyr Gly Gly Leu Leu  Asp Glu Met 
    3395                 3400                 3405             


Phe Asn  His Ala Gly Ala Gly  Arg Phe Arg Phe Leu  Gly Ser Ile 
    3410                 3415                 3420             


Leu Val  Asn Leu Ser Ser Cys  Val Ala Leu Asn Arg  Phe Gln Ala 
    3425                 3430                 3435             


Leu Gln  Ser Val Asp Ile Leu  Glu Thr Lys Ala His  Glu Leu Leu 
    3440                 3445                 3450             


Gln Gln  Asn Ser Phe Leu Ala  Ser Ile Ile Phe Ser  Asn Ser Leu 
    3455                 3460                 3465             


Phe Asp  Lys Asn Phe Arg Ser  Glu Ser Val Lys Leu  Pro Pro His 
    3470                 3475                 3480             


Val Ser  Tyr Thr Ile Arg Thr  Asn Val Leu Tyr Ser  Val Arg Thr 
    3485                 3490                 3495             


Asp Val  Val Lys Asn Pro Ser  Trp Lys Phe His Pro  Gln Asn Leu 
    3500                 3505                 3510             


Pro Ala  Asp Gly Phe Lys Tyr  Asn Tyr Val Phe Ala  Pro Leu Gln 
    3515                 3520                 3525             


Asp Met  Ile Glu Arg Ala Ile  Ile Leu Val Gln Thr  Gly Gln Glu 
    3530                 3535                 3540             


Ala Leu  Glu Pro Ala Ala Gln  Thr Gln Ala Ala Pro  Tyr Pro Cys 
    3545                 3550                 3555             


His Thr  Ser Asp Leu Phe Leu  Asn Asn Val Gly Phe  Phe Phe Pro 
    3560                 3565                 3570             


Leu Ile  Met Met Leu Thr Trp  Met Val Ser Val Ala  Ser Met Val 
    3575                 3580                 3585             


Arg Lys  Leu Val Tyr Glu Gln  Glu Ile Gln Ile Glu  Glu Tyr Met 
    3590                 3595                 3600             


Arg Met  Met Gly Val His Pro  Val Ile His Phe Leu  Ala Trp Phe 
    3605                 3610                 3615             


Leu Glu  Asn Met Ala Val Leu  Thr Ile Ser Ser Ala  Thr Leu Ala 
    3620                 3625                 3630             


Ile Val  Leu Lys Thr Ser Gly  Ile Phe Ala His Ser  Asn Thr Phe 
    3635                 3640                 3645             


Ile Val  Phe Leu Phe Leu Leu  Asp Phe Gly Met Ser  Val Val Met 
    3650                 3655                 3660             


Leu Ser  Tyr Leu Leu Ser Ala  Phe Phe Ser Gln Ala  Asn Thr Ala 
    3665                 3670                 3675             


Ala Leu  Cys Thr Ser Leu Val  Tyr Met Ile Ser Phe  Leu Pro Tyr 
    3680                 3685                 3690             


Ile Val  Leu Leu Val Leu His  Asn Gln Leu Ser Phe  Val Asn Gln 
    3695                 3700                 3705             


Thr Phe  Leu Cys Leu Leu Ser  Thr Thr Ala Phe Gly  Gln Gly Val 
    3710                 3715                 3720             


Phe Phe  Ile Thr Phe Leu Glu  Gly Gln Glu Thr Gly  Ile Gln Trp 
    3725                 3730                 3735             


Asn Asn  Met Tyr Gln Ala Leu  Glu Gln Gly Gly Met  Thr Phe Gly 
    3740                 3745                 3750             


Trp Val  Cys Trp Met Ile Leu  Phe Asp Ser Ser Leu  Tyr Phe Leu 
    3755                 3760                 3765             


Cys Gly  Trp Tyr Leu Ser Asn  Leu Ile Pro Gly Thr  Phe Gly Leu 
    3770                 3775                 3780             


Arg Lys  Pro Trp Tyr Phe Pro  Phe Thr Ala Ser Tyr  Trp Lys Ser 
    3785                 3790                 3795             


Val Gly  Phe Leu Val Glu Lys  Arg Gln Tyr Phe Leu  Ser Ser Ser 
    3800                 3805                 3810             


Leu Phe  Phe Phe Asn Glu Asn  Phe Asp Asn Lys Gly  Ser Ser Leu 
    3815                 3820                 3825             


Gln Asn  Arg Glu Gly Glu Leu  Glu Gly Ser Ala Pro  Gly Val Thr 
    3830                 3835                 3840             


Leu Val  Ser Val Thr Lys Glu  Tyr Glu Gly His Lys  Ala Val Val 
    3845                 3850                 3855             


Gln Asp  Leu Ser Leu Thr Phe  Tyr Arg Asp Gln Ile  Thr Ala Leu 
    3860                 3865                 3870             


Leu Gly  Thr Asn Gly Ala Gly  Lys Thr Thr Ile Ile  Ser Met Leu 
    3875                 3880                 3885             


Thr Gly  Leu His Pro Pro Thr  Ser Gly Thr Ile Ile  Ile Asn Gly 
    3890                 3895                 3900             


Lys Asn  Leu Gln Thr Asp Leu  Ser Arg Val Arg Met  Glu Leu Gly 
    3905                 3910                 3915             


Val Cys  Pro Gln Gln Asp Ile  Leu Leu Asp Asn Leu  Thr Val Arg 
    3920                 3925                 3930             


Glu His  Leu Leu Leu Phe Ala  Ser Ile Lys Ala Pro  Gln Trp Thr 
    3935                 3940                 3945             


Lys Lys  Glu Leu His Gln Gln  Val Asn Gln Thr Leu  Gln Asp Val 
    3950                 3955                 3960             


Asp Leu  Thr Gln His Gln His  Lys Gln Thr Arg Ala  Leu Ser Gly 
    3965                 3970                 3975             


Gly Leu  Lys Arg Lys Leu Ser  Leu Gly Ile Ala Phe  Met Gly Met 
    3980                 3985                 3990             


Ser Arg  Thr Val Val Leu Asp  Glu Pro Thr Ser Gly  Val Asp Pro 
    3995                 4000                 4005             


Cys Ser  Arg His Ser Leu Trp  Asp Ile Leu Leu Lys  Tyr Arg Glu 
    4010                 4015                 4020             


Gly Arg  Thr Ile Ile Phe Thr  Thr His His Leu Asp  Glu Ala Glu 
    4025                 4030                 4035             


Ala Leu  Ser Asp Arg Val Ala  Val Leu Gln His Gly  Arg Leu Arg 
    4040                 4045                 4050             


Cys Cys  Gly Pro Pro Phe Cys  Leu Lys Glu Ala Tyr  Gly Gln Gly 
    4055                 4060                 4065             


Leu Arg  Leu Thr Leu Thr Arg  Gln Pro Ser Val Leu  Glu Ala His 
    4070                 4075                 4080             


Asp Leu  Lys Asp Met Ala Cys  Val Thr Ser Leu Ile  Lys Ile Tyr 
    4085                 4090                 4095             


Ile Pro  Gln Ala Phe Leu Lys  Asp Ser Ser Gly Ser  Glu Leu Thr 
    4100                 4105                 4110             


Tyr Thr  Ile Pro Lys Asp Thr  Asp Lys Ala Cys Leu  Lys Gly Leu 
    4115                 4120                 4125             


Phe Gln  Ala Leu Asp Glu Asn  Leu His Gln Leu His  Leu Thr Gly 
    4130                 4135                 4140             


Tyr Gly  Ile Ser Asp Thr Thr  Leu Glu Glu Val Phe  Leu Met Leu 
    4145                 4150                 4155             


Leu Gln  Asp Ser Asn Lys Lys  Ser His Ile Ala Leu  Gly Thr Glu 
    4160                 4165                 4170             


Ser Glu  Leu Gln Asn His Arg  Pro Thr Gly His Leu  Ser Gly Tyr 
    4175                 4180                 4185             


Cys Gly  Ser Leu Ala Arg Pro  Ala Thr Val Gln Gly  Val Gln Leu 
    4190                 4195                 4200             


Leu Arg  Ala Gln Val Ala Ala  Ile Leu Ala Arg Arg  Leu Arg Arg 
    4205                 4210                 4215             


Thr Leu  Arg Ala Gly Lys Ser  Thr Leu Ala Asp Leu  Leu Leu Pro 
    4220                 4225                 4230             


Val Leu  Phe Val Ala Leu Ala  Met Gly Leu Phe Met  Val Arg Pro 
    4235                 4240                 4245             


Leu Ala  Thr Glu Tyr Pro Pro  Leu Arg Leu Thr Pro  Gly His Tyr 
    4250                 4255                 4260             


Gln Arg  Ala Glu Thr Tyr Phe  Phe Ser Ser Gly Gly  Asp Asn Leu 
    4265                 4270                 4275             


Asp Leu  Thr Arg Val Leu Leu  Arg Lys Phe Arg Asp  Gln Asp Leu 
    4280                 4285                 4290             


Pro Cys  Ala Asp Leu Asn Pro  Arg Gln Lys Asn Ser  Ser Cys Trp 
    4295                 4300                 4305             


Arg Thr  Asp Pro Phe Ser His  Pro Glu Phe Gln Asp  Ser Cys Gly 
    4310                 4315                 4320             


Cys Leu  Lys Cys Pro Asn Arg  Ser Ala Ser Ala Pro  Tyr Leu Thr 
    4325                 4330                 4335             


Asn His  Leu Gly His Thr Leu  Leu Asn Leu Ser Gly  Phe Asn Met 
    4340                 4345                 4350             


Glu Glu  Tyr Leu Leu Ala Pro  Ser Glu Lys Pro Arg  Leu Gly Gly 
    4355                 4360                 4365             


Trp Ser  Phe Gly Leu Lys Ile  Pro Ser Glu Ala Gly  Gly Ala Asn 
    4370                 4375                 4380             


Gly Asn  Ile Ser Lys Pro Pro  Thr Leu Ala Lys Val  Trp Tyr Asn 
    4385                 4390                 4395             


Gln Lys  Gly Phe His Ser Leu  Pro Ser Tyr Leu Asn  His Leu Asn 
    4400                 4405                 4410             


Asn Leu  Ile Leu Trp Gln His  Leu Pro Pro Thr Val  Asp Trp Arg 
    4415                 4420                 4425             


Gln Tyr  Gly Ile Thr Leu Tyr  Ser His Pro Tyr Gly  Gly Ala Leu 
    4430                 4435                 4440             


Leu Asn  Glu Asp Lys Ile Leu  Glu Ser Ile Arg Gln  Cys Gly Val 
    4445                 4450                 4455             


Ala Leu  Cys Ile Val Leu Gly  Phe Ser Ile Leu Ser  Ala Ser Ile 
    4460                 4465                 4470             


Gly Ser  Ser Val Val Arg Asp  Arg Val Ile Gly Ala  Lys Arg Leu 
    4475                 4480                 4485             


Gln His  Ile Ser Gly Leu Gly  Tyr Arg Met Tyr Trp  Phe Thr Asn 
    4490                 4495                 4500             


Phe Leu  Tyr Asp Met Leu Phe  Tyr Leu Val Ser Val  Cys Leu Cys 
    4505                 4510                 4515             


Val Ala  Val Ile Val Ala Phe  Gln Leu Thr Ala Phe  Thr Phe Arg 
    4520                 4525                 4530             


Lys Asn  Leu Ala Ala Thr Ala  Leu Leu Leu Ser Leu  Phe Gly Tyr 
    4535                 4540                 4545             


Ala Thr  Leu Pro Trp Met Tyr  Leu Met Ser Arg Ile  Phe Ser Ser 
    4550                 4555                 4560             


Ser Asp  Val Ala Phe Ile Ser  Tyr Val Ser Leu Asn  Phe Ile Phe 
    4565                 4570                 4575             


Gly Leu  Cys Thr Met Leu Ile  Thr Ile Met Pro Arg  Leu Leu Ala 
    4580                 4585                 4590             


Ile Ile  Ser Lys Ala Lys Asn  Leu Gln Asn Ile Tyr  Asp Val Leu 
    4595                 4600                 4605             


Lys Trp  Val Phe Thr Ile Phe  Pro Gln Phe Cys Leu  Gly Gln Gly 
    4610                 4615                 4620             


Leu Val  Glu Leu Cys Tyr Asn  Gln Ile Lys Tyr Asp  Leu Thr His 
    4625                 4630                 4635             


Asn Phe  Gly Ile Asp Ser Tyr  Val Ser Pro Phe Glu  Met Asn Phe 
    4640                 4645                 4650             


Leu Gly  Trp Ile Phe Val Gln  Leu Ala Ser Gln Gly  Thr Val Leu 
    4655                 4660                 4665             


Leu Leu  Leu Arg Val Leu Leu  His Trp Asp Leu Leu  Arg Trp Pro 
    4670                 4675                 4680             


Arg Gly  His Ser Thr Leu Gln  Gly Thr Val Lys Ser  Ser Lys Asp 
    4685                 4690                 4695             


Thr Asp  Val Glu Lys Glu Glu  Lys Arg Val Phe Glu  Gly Arg Thr 
    4700                 4705                 4710             


Asn Gly  Asp Ile Leu Val Leu  Tyr Asn Leu Ser Lys  His Tyr Arg 
    4715                 4720                 4725             


Arg Phe  Phe Gln Asn Ile Ile  Ala Val Gln Asp Ile  Ser Leu Gly 
    4730                 4735                 4740             


Ile Pro  Lys Gly Glu Cys Phe  Gly Leu Leu Gly Val  Asn Gly Ala 
    4745                 4750                 4755             


Gly Lys  Ser Thr Thr Phe Lys  Met Leu Asn Gly Glu  Val Ser Leu 
    4760                 4765                 4770             


Thr Ser  Gly His Ala Ile Ile  Arg Thr Pro Met Gly  Asp Ala Val 
    4775                 4780                 4785             


Asp Leu  Ser Ser Ala Gly Thr  Ala Gly Val Leu Ile  Gly Tyr Cys 
    4790                 4795                 4800             


Pro Gln  Gln Asp Ala Leu Asp  Glu Leu Leu Thr Gly  Trp Glu His 
    4805                 4810                 4815             


Leu Tyr  Tyr Tyr Cys Ser Leu  Arg Gly Ile Pro Arg  Gln Cys Ile 
    4820                 4825                 4830             


Pro Glu  Val Ala Gly Asp Leu  Ile Arg Arg Leu His  Leu Glu Ala 
    4835                 4840                 4845             


His Ala  Asp Lys Pro Val Ala  Thr Tyr Ser Gly Gly  Thr Lys Arg 
    4850                 4855                 4860             


Lys Leu  Ser Thr Ala Leu Ala  Leu Val Gly Lys Pro  Asp Ile Leu 
    4865                 4870                 4875             


Leu Leu  Asp Glu Pro Ser Ser  Gly Met Asp Pro Cys  Ser Lys Arg 
    4880                 4885                 4890             


Tyr Leu  Trp Gln Thr Ile Met  Lys Glu Val Arg Glu  Gly Cys Ala 
    4895                 4900                 4905             


Ala Val  Leu Thr Ser His Ser  Met Glu Glu Cys Glu  Ala Leu Cys 
    4910                 4915                 4920             


Thr Arg  Leu Ala Ile Met Val  Asn Gly Ser Phe Lys  Cys Leu Gly 
    4925                 4930                 4935             


Ser Pro  Gln His Ile Lys Asn  Arg Phe Gly Asp Gly  Tyr Thr Val 
    4940                 4945                 4950             


Lys Val  Trp Leu Cys Lys Glu  Ala Asn Gln His Cys  Thr Val Ser 
    4955                 4960                 4965             


Asp His  Leu Lys Leu Tyr Phe  Pro Gly Ile Gln Phe  Lys Gly Gln 
    4970                 4975                 4980             


His Leu  Asn Leu Leu Glu Tyr  His Val Pro Lys Arg  Trp Gly Cys 
    4985                 4990                 4995             


Leu Ala  Asp Leu Phe Lys Val  Ile Glu Asn Asn Lys  Thr Phe Leu 
    5000                 5005                 5010             


Asn Ile  Lys His Tyr Ser Ile  Asn Gln Thr Thr Leu  Glu Gln Val 
    5015                 5020                 5025             


Phe Ile  Asn Phe Ala Ser Glu  Gln Gln Gln Thr Leu  Gln Ser Thr 
    5030                 5035                 5040             


Leu Asp  Pro Ser Thr Asp Ser  His His Thr His His  Leu Pro Ile 
    5045                 5050                 5055             


<210>  6103
<211>  705
<212>  PRT
<213>  Homo sapiens

<400>  6103

Met Thr Lys Phe Gly Phe Leu Arg Leu Ser Tyr Glu Lys Gln Asp Thr 
1               5                   10                  15      


Leu Leu Lys Leu Leu Ile Leu Ser Met Ala Ala Val Leu Ser Phe Ser 
            20                  25                  30          


Thr Arg Leu Phe Ala Val Leu Arg Phe Glu Ser Val Ile His Glu Phe 
        35                  40                  45              


Asp Pro Tyr Phe Asn Tyr Arg Thr Thr Arg Phe Leu Ala Glu Glu Gly 
    50                  55                  60                  


Phe Tyr Lys Phe His Asn Trp Phe Asp Asp Arg Ala Trp Tyr Pro Leu 
65                  70                  75                  80  


Gly Arg Ile Ile Gly Gly Thr Ile Tyr Pro Gly Leu Met Ile Thr Ser 
                85                  90                  95      


Ala Ala Ile Tyr His Val Leu His Phe Phe His Ile Thr Ile Asp Ile 
            100                 105                 110         


Arg Asn Val Cys Val Phe Leu Ala Pro Leu Phe Ser Ser Phe Thr Thr 
        115                 120                 125             


Ile Val Thr Tyr His Leu Thr Lys Glu Leu Lys Asp Ala Gly Ala Gly 
    130                 135                 140                 


Leu Leu Ala Ala Ala Met Ile Ala Val Val Pro Gly Tyr Ile Ser Arg 
145                 150                 155                 160 


Ser Val Ala Gly Ser Tyr Asp Asn Glu Gly Ile Ala Ile Phe Cys Met 
                165                 170                 175     


Leu Leu Thr Tyr Tyr Met Trp Ile Lys Ala Val Lys Thr Gly Ser Ile 
            180                 185                 190         


Cys Trp Ala Ala Lys Cys Ala Leu Ala Tyr Phe Tyr Met Val Ser Ser 
        195                 200                 205             


Trp Gly Gly Tyr Val Phe Leu Ile Asn Leu Ile Pro Leu His Val Leu 
    210                 215                 220                 


Val Leu Met Leu Thr Gly Arg Phe Ser His Arg Ile Tyr Val Ala Tyr 
225                 230                 235                 240 


Cys Thr Val Tyr Cys Leu Gly Thr Ile Leu Ser Met Gln Ile Ser Phe 
                245                 250                 255     


Val Gly Phe Gln Pro Val Leu Ser Ser Glu His Met Ala Ala Phe Gly 
            260                 265                 270         


Val Phe Gly Leu Cys Gln Ile His Ala Phe Val Asp Tyr Leu Arg Ser 
        275                 280                 285             


Lys Leu Asn Pro Gln Gln Phe Glu Val Leu Phe Arg Ser Val Ile Ser 
    290                 295                 300                 


Leu Val Gly Phe Val Leu Leu Thr Val Gly Ala Leu Leu Met Leu Thr 
305                 310                 315                 320 


Gly Lys Ile Ser Pro Trp Thr Gly Arg Phe Tyr Ser Leu Leu Asp Pro 
                325                 330                 335     


Ser Tyr Ala Lys Asn Asn Ile Pro Ile Ile Ala Ser Val Ser Glu His 
            340                 345                 350         


Gln Pro Thr Thr Trp Ser Ser Tyr Tyr Phe Asp Leu Gln Leu Leu Val 
        355                 360                 365             


Phe Met Phe Pro Val Gly Leu Tyr Tyr Cys Phe Ser Asn Leu Ser Asp 
    370                 375                 380                 


Ala Arg Ile Phe Ile Ile Met Tyr Gly Val Thr Ser Met Tyr Phe Ser 
385                 390                 395                 400 


Ala Val Met Val Arg Leu Met Leu Val Leu Ala Pro Val Met Cys Ile 
                405                 410                 415     


Leu Ser Gly Ile Gly Val Ser Gln Val Leu Ser Thr Tyr Met Lys Asn 
            420                 425                 430         


Leu Asp Ile Ser Arg Pro Asp Lys Lys Ser Lys Lys Gln Gln Asp Ser 
        435                 440                 445             


Thr Tyr Pro Ile Lys Asn Glu Val Ala Ser Gly Met Ile Leu Val Met 
    450                 455                 460                 


Ala Phe Phe Leu Ile Thr Tyr Thr Phe His Ser Thr Trp Val Thr Ser 
465                 470                 475                 480 


Glu Ala Tyr Ser Ser Pro Ser Ile Val Leu Ser Ala Arg Gly Gly Asp 
                485                 490                 495     


Gly Ser Arg Ile Ile Phe Asp Asp Phe Arg Glu Ala Tyr Tyr Trp Leu 
            500                 505                 510         


Arg His Asn Thr Pro Glu Asp Ala Lys Val Met Ser Trp Trp Asp Tyr 
        515                 520                 525             


Gly Tyr Gln Ile Thr Ala Met Ala Asn Arg Thr Ile Leu Val Asp Asn 
    530                 535                 540                 


Asn Thr Trp Asn Asn Thr His Ile Ser Arg Val Gly Gln Ala Met Ala 
545                 550                 555                 560 


Ser Thr Glu Glu Lys Ala Tyr Glu Ile Met Arg Glu Leu Asp Val Ser 
                565                 570                 575     


Tyr Val Leu Val Ile Phe Gly Gly Leu Thr Gly Tyr Ser Ser Asp Asp 
            580                 585                 590         


Ile Asn Lys Phe Leu Trp Met Val Arg Ile Gly Gly Ser Thr Asp Thr 
        595                 600                 605             


Gly Lys His Ile Lys Glu Asn Asp Tyr Tyr Thr Pro Thr Gly Glu Phe 
    610                 615                 620                 


Arg Val Asp Arg Glu Gly Ser Pro Val Leu Leu Asn Cys Leu Met Tyr 
625                 630                 635                 640 


Lys Met Cys Tyr Tyr Arg Phe Gly Gln Val Tyr Thr Glu Ala Lys Arg 
                645                 650                 655     


Pro Pro Gly Phe Asp Arg Val Arg Asn Ala Glu Ile Gly Asn Lys Asp 
            660                 665                 670         


Phe Glu Leu Asp Val Leu Glu Glu Ala Tyr Thr Thr Glu His Trp Leu 
        675                 680                 685             


Val Arg Ile Tyr Lys Val Lys Asp Leu Asp Asn Arg Gly Leu Ser Arg 
    690                 695                 700                 


Thr 
705 


<210>  6104
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  6104

Met Val Arg Arg Gly His Val Gly Ile Phe Phe Ile Glu Gly Gly Val 
1               5                   10                  15      


Pro Phe Trp Gly Gly Ala Cys Phe Ile Ile Ser Gly Ser Leu Ser Val 
            20                  25                  30          


Ala Ala Glu Lys Asn His Thr Ser Cys Leu Val Arg Ser Ser Leu Gly 
        35                  40                  45              


Thr Asn Ile Leu Ser Val Met Ala Ala Phe Ala Gly Thr Ala Ile Leu 
    50                  55                  60                  


Leu Met Asp Phe Gly Val Thr Asn Arg Asp Val Asp Arg Gly Tyr Leu 
65                  70                  75                  80  


Ala Val Leu Thr Ile Phe Thr Val Leu Glu Phe Phe Thr Ala Val Ile 
                85                  90                  95      


Ala Met His Phe Gly Cys Gln Ala Ile His Ala Gln Ala Ser Ala Pro 
            100                 105                 110         


Val Ile Phe Leu Pro Asn Ala Phe Ser Ala Asp Phe Asn Ile Pro Ser 
        115                 120                 125             


Pro Ala Ala Ser Ala Pro Pro Ala Tyr Asp Asn Val Ala Tyr Ala Gln 
    130                 135                 140                 


Gly Val Val 
145         


<210>  6105
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  6105

Met Lys Arg Glu Arg Gly Ala Leu Ser Arg Ala Ser Arg Ala Leu Arg 
1               5                   10                  15      


Leu Ala Pro Phe Val Tyr Leu Leu Leu Ile Gln Thr Asp Pro Leu Glu 
            20                  25                  30          


Gly Val Asn Ile Thr Ser Pro Val Arg Leu Ile His Gly Thr Val Gly 
        35                  40                  45              


Lys Ser Ala Leu Leu Ser Val Gln Tyr Ser Ser Thr Ser Ser Asp Arg 
    50                  55                  60                  


Pro Val Val Lys Trp Gln Leu Lys Arg Asp Lys Pro Val Thr Val Val 
65                  70                  75                  80  


Gln Ser Ile Gly Thr Glu Val Ile Gly Thr Leu Arg Pro Asp Tyr Arg 
                85                  90                  95      


Asp Arg Ile Arg Leu Phe Glu Asn Gly Ser Leu Leu Leu Ser Asp Leu 
            100                 105                 110         


Gln Leu Ala Asp Glu Gly Thr Tyr Glu Val Glu Ile Ser Ile Thr Asp 
        115                 120                 125             


Asp Thr Phe Thr Gly Glu Lys Thr Ile Asn Leu Thr Val Asp Val Pro 
    130                 135                 140                 


Ile Ser Arg Pro Gln Val Leu Val Ala Ser Thr Thr Val Leu Glu Leu 
145                 150                 155                 160 


Ser Glu Ala Phe Thr Leu Asn Cys Ser His Glu Asn Gly Thr Lys Pro 
                165                 170                 175     


Ser Tyr Thr Trp Leu Lys Asp Gly Lys Pro Leu Leu Asn Asp Ser Arg 
            180                 185                 190         


Met Leu Leu Ser Pro Asp Gln Lys Val Leu Thr Ile Thr Arg Val Leu 
        195                 200                 205             


Met Glu Asp Asp Asp Leu Tyr Ser Cys Met Val Glu Asn Pro Ile Ser 
    210                 215                 220                 


Gln Gly Arg Ser Leu Pro Val Lys Ile Thr Val Tyr Arg Arg Ser Ser 
225                 230                 235                 240 


Leu Tyr Ile Ile Leu Ser Thr Gly Gly Ile Phe Leu Leu Val Thr Leu 
                245                 250                 255     


Val Thr Val Cys Ala Cys Trp Lys Pro Ser Lys Arg Lys Gln Lys Lys 
            260                 265                 270         


Leu Glu Lys Gln Asn Ser Leu Glu Tyr Met Asp Gln Asn Asp Asp Arg 
        275                 280                 285             


Leu Lys Pro Glu Ala Asp Thr Leu Pro Arg Ser Gly Glu Gln Glu Arg 
    290                 295                 300                 


Lys Asn Pro Met Ala Leu Tyr Ile Leu Lys Asp Lys Asp Ser Pro Glu 
305                 310                 315                 320 


Thr Glu Glu Asn Pro Ala Pro Glu Pro Arg Ser Ala Thr Glu Pro Gly 
                325                 330                 335     


Pro Pro Gly Tyr Ser Val Ser Pro Ala Val Pro Gly Arg Ser Pro Gly 
            340                 345                 350         


Leu Pro Ile Arg Ser Ala Arg Arg Tyr Pro Arg Ser Pro Ala Arg Ser 
        355                 360                 365             


Pro Ala Thr Gly Arg Thr His Ser Ser Pro Pro Arg Ala Pro Ser Ser 
    370                 375                 380                 


Pro Gly Arg Ser Arg Ser Ala Ser Arg Thr Leu Arg Thr Ala Gly Val 
385                 390                 395                 400 


His Ile Ile Arg Glu Gln Asp Glu Ala Gly Pro Val Glu Ile Ser Ala 
                405                 410                 415     


<210>  6106
<211>  654
<212>  PRT
<213>  Homo sapiens

<400>  6106

Met Cys Phe Arg Thr Lys Leu Ser Val Ser Trp Val Pro Leu Phe Leu 
1               5                   10                  15      


Leu Leu Ser Arg Val Phe Ser Thr Glu Thr Asp Lys Pro Ser Ala Gln 
            20                  25                  30          


Asp Ser Arg Ser Arg Gly Ser Ser Gly Gln Pro Ala Asp Leu Leu Gln 
        35                  40                  45              


Val Leu Ser Ala Gly Asp His Pro Pro His Asn His Ser Arg Ser Leu 
    50                  55                  60                  


Ile Lys Thr Leu Leu Glu Lys Thr Gly Cys Pro Arg Arg Arg Asn Gly 
65                  70                  75                  80  


Met Gln Gly Asp Cys Asn Leu Cys Phe Glu Pro Asp Ala Leu Leu Leu 
                85                  90                  95      


Ile Ala Gly Gly Asn Phe Glu Asp Gln Leu Arg Glu Glu Val Val Gln 
            100                 105                 110         


Arg Val Ser Leu Leu Leu Leu Tyr Tyr Ile Ile His Gln Glu Glu Ile 
        115                 120                 125             


Cys Ser Ser Lys Leu Asn Met Ser Asn Lys Glu Tyr Lys Phe Tyr Leu 
    130                 135                 140                 


His Ser Leu Leu Ser Leu Arg Gln Asp Glu Asp Ser Ser Phe Leu Ser 
145                 150                 155                 160 


Gln Asn Glu Thr Glu Asp Ile Leu Ala Phe Thr Arg Gln Tyr Phe Asp 
                165                 170                 175     


Thr Ser Gln Ser Gln Cys Met Glu Thr Lys Thr Leu Gln Lys Lys Ser 
            180                 185                 190         


Gly Ile Val Ser Ser Glu Gly Ala Asn Glu Ser Thr Leu Pro Gln Leu 
        195                 200                 205             


Ala Ala Met Ile Ile Thr Leu Ser Leu Gln Gly Val Cys Leu Gly Gln 
    210                 215                 220                 


Gly Asn Leu Pro Ser Pro Asp Tyr Phe Thr Glu Tyr Ile Phe Ser Ser 
225                 230                 235                 240 


Leu Asn Arg Thr Asn Thr Leu Arg Leu Ser Glu Leu Asp Gln Leu Leu 
                245                 250                 255     


Asn Thr Leu Trp Thr Arg Ser Thr Cys Ile Lys Asn Glu Lys Ile His 
            260                 265                 270         


Gln Phe Gln Arg Lys Gln Asn Asn Ile Ile Thr His Asp Gln Asp Tyr 
        275                 280                 285             


Ser Asn Phe Ser Ser Ser Met Glu Lys Glu Ser Glu Asp Gly Pro Val 
    290                 295                 300                 


Ser Trp Asp Gln Thr Cys Phe Ser Ala Arg Gln Leu Val Glu Ile Phe 
305                 310                 315                 320 


Leu Gln Lys Gly Leu Ser Leu Ile Ser Lys Glu Asp Phe Lys Gln Met 
                325                 330                 335     


Ser Pro Gly Ile Ile Gln Gln Leu Leu Ser Cys Ser Cys His Leu Pro 
            340                 345                 350         


Lys Asp Gln Gln Ala Lys Leu Pro Pro Thr Thr Leu Glu Lys Tyr Gly 
        355                 360                 365             


Tyr Ser Thr Val Ala Val Thr Leu Leu Thr Leu Gly Ser Met Leu Gly 
    370                 375                 380                 


Thr Ala Leu Val Leu Phe His Ser Cys Glu Glu Asn Tyr Arg Leu Ile 
385                 390                 395                 400 


Leu Gln Leu Phe Val Gly Leu Ala Val Gly Thr Leu Ser Gly Asp Ala 
                405                 410                 415     


Leu Leu His Leu Ile Pro Gln Val Leu Gly Leu His Lys Gln Glu Ala 
            420                 425                 430         


Pro Glu Phe Gly His Phe His Glu Ser Lys Gly His Ile Trp Lys Leu 
        435                 440                 445             


Met Gly Leu Ile Gly Gly Ile His Gly Phe Phe Leu Ile Glu Lys Cys 
    450                 455                 460                 


Phe Ile Leu Leu Val Ser Pro Asn Asp Lys Lys Ser Pro Glu Asp Ser 
465                 470                 475                 480 


Gln Ala Ala Glu Met Pro Ile Gly Ser Met Thr Ala Ser Asn Arg Lys 
                485                 490                 495     


Cys Lys Ala Ile Ser Leu Leu Ala Ile Met Ile Leu Val Gly Asp Ser 
            500                 505                 510         


Leu His Asn Phe Ala Asp Gly Leu Ala Ile Gly Ala Ala Phe Ser Ser 
        515                 520                 525             


Ser Ser Glu Ser Gly Val Thr Thr Thr Ile Ala Ile Leu Cys His Glu 
    530                 535                 540                 


Ile Pro His Glu Met Gly Asp Phe Ala Val Leu Leu Ser Ser Gly Leu 
545                 550                 555                 560 


Ser Met Lys Thr Ala Ile Leu Met Asn Phe Ile Ser Ser Leu Thr Ala 
                565                 570                 575     


Phe Met Gly Leu Tyr Ile Gly Leu Ser Val Ser Ala Asp Pro Cys Val 
            580                 585                 590         


Gln Asp Trp Ile Phe Thr Val Thr Ala Gly Met Phe Leu Tyr Leu Ser 
        595                 600                 605             


Leu Val Glu Met Leu Pro Glu Met Thr His Val Gln Thr Gln Arg Pro 
    610                 615                 620                 


Trp Met Met Phe Leu Leu Gln Asn Phe Gly Leu Ile Leu Gly Trp Leu 
625                 630                 635                 640 


Ser Leu Leu Leu Leu Ala Ile Tyr Glu Gln Asn Ile Lys Ile 
                645                 650                 


<210>  6107
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  6107

Met Asp Phe Ile Leu Glu Asp Met Asp Leu Ala Ala Asn Glu Ile Ser 
1               5                   10                  15      


Ile Tyr Asp Lys Leu Ser Glu Thr Val Asp Leu Val Arg Gln Thr Gly 
            20                  25                  30          


His Gln Cys Gly Met Ser Glu Lys Ala Ile Glu Lys Phe Ile Arg Gln 
        35                  40                  45              


Leu Leu Glu Lys Asn Glu Pro Gln Arg Pro Pro Pro Gln Tyr Pro Leu 
    50                  55                  60                  


Leu Ile Val Val Tyr Lys Val Leu Ala Thr Leu Gly Leu Ile Leu Leu 
65                  70                  75                  80  


Thr Ala Tyr Phe Val Ile Gln Pro Phe Ser Pro Leu Ala Pro Glu Pro 
                85                  90                  95      


Val Leu Ser Gly Ala His Thr Trp Arg Ser Leu Ile His His Ile Arg 
            100                 105                 110         


Leu Met Ser Leu Pro Ile Ala Lys Lys Tyr Met Ser Glu Asn Lys Gly 
        115                 120                 125             


Val Pro Leu His Gly Gly Asp Glu Asp Arg Pro Phe Pro Asp Phe Asp 
    130                 135                 140                 


Pro Trp Trp Thr Asn Asp Cys Glu Gln Asn Glu Ser Glu Pro Ile Pro 
145                 150                 155                 160 


Ala Asn Cys Thr Gly Cys Ala Gln Lys His Leu Lys Val Met Leu Leu 
                165                 170                 175     


Glu Asp Ala Pro Arg Lys Phe Glu Arg Leu His Pro Leu Val Ile Lys 
            180                 185                 190         


Thr Gly Lys Pro Leu Leu Glu Glu Glu Ile Gln His Phe Leu Cys Gln 
        195                 200                 205             


Tyr Pro Glu Ala Thr Glu Gly Phe Ser Glu Gly Phe Phe Ala Lys Trp 
    210                 215                 220                 


Trp Arg Cys Phe Pro Glu Arg Trp Phe Pro Phe Pro Tyr Pro Trp Arg 
225                 230                 235                 240 


Arg Pro Leu Asn Arg Ser Gln Met Leu Arg Glu Leu Phe Pro Val Phe 
                245                 250                 255     


Thr His Leu Pro Phe Pro Lys Asp Ala Ser Leu Asn Lys Cys Ser Phe 
            260                 265                 270         


Leu His Pro Glu Pro Val Val Gly Ser Lys Met His Lys Met Pro Asp 
        275                 280                 285             


Leu Phe Ile Ile Gly Ser Gly Glu Ala Met Leu Gln Leu Ile Pro Pro 
    290                 295                 300                 


Phe Gln Cys Arg Arg His Cys Gln Ser Val Ala Met Pro Ile Glu Pro 
305                 310                 315                 320 


Gly Asp Ile Gly Tyr Val Asp Thr Thr His Trp Lys Val Tyr Val Ile 
                325                 330                 335     


Ala Arg Gly Val Gln Pro Leu Val Ile Cys Asp Gly Thr Ala Phe Ser 
            340                 345                 350         


Glu Leu 
        


<210>  6108
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  6108

Met Ala Ser Gln Pro Pro Glu Asp Thr Ala Glu Ser Gln Ala Ser Asp 
1               5                   10                  15      


Glu Leu Glu Cys Lys Ile Cys Tyr Asn Arg Tyr Asn Leu Lys Gln Arg 
            20                  25                  30          


Lys Pro Lys Val Leu Glu Cys Cys His Arg Val Cys Ala Lys Cys Leu 
        35                  40                  45              


Tyr Lys Ile Ile Asp Phe Gly Asp Ser Pro Gln Gly Val Ile Val Cys 
    50                  55                  60                  


Pro Phe Cys Arg Phe Glu Thr Cys Leu Pro Asp Asp Glu Val Ser Ser 
65                  70                  75                  80  


Leu Pro Asp Asp Asn Asn Ile Leu Val Asn Leu Thr Cys Gly Gly Lys 
                85                  90                  95      


Gly Lys Lys Cys Leu Pro Glu Asn Pro Thr Glu Leu Leu Leu Thr Pro 
            100                 105                 110         


Lys Arg Leu Ala Ser Leu Val Ser Pro Ser His Thr Ser Ser Asn Cys 
        115                 120                 125             


Leu Val Ile Thr Ile Met Glu Val Gln Arg Glu Ser Ser Pro Ser Leu 
    130                 135                 140                 


Ser Ser Thr Pro Val Val Glu Phe Tyr Arg Pro Ala Ser Phe Asp Ser 
145                 150                 155                 160 


Val Thr Thr Val Ser His Asn Trp Thr Val Trp Asn Cys Thr Ser Leu 
                165                 170                 175     


Leu Phe Gln Thr Ser Ile Arg Val Leu Val Trp Leu Leu Gly Leu Leu 
            180                 185                 190         


Tyr Phe Ser Ser Leu Pro Leu Gly Ile Tyr Leu Leu Val Ser Lys Lys 
        195                 200                 205             


Val Thr Leu Gly Val Val Phe Val Ser Leu Val Pro Ser Ser Leu Val 
    210                 215                 220                 


Ile Leu Met Val Tyr Gly Phe Cys Gln Cys Val Cys His Glu Phe Leu 
225                 230                 235                 240 


Asp Cys Met Ala Pro Pro Ser 
                245         


<210>  6109
<211>  2213
<212>  PRT
<213>  Homo sapiens

<400>  6109

Met Ala Arg Gly Ala Arg Pro Ser Ala Ala Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Ala Glu Pro Pro Glu Arg Ala Gly Pro Gly Arg Pro Arg Gly Ser Pro 
            20                  25                  30          


Pro Gly Arg Ala Arg Pro Ser Leu Ala Pro Arg Pro Gly Pro Glu Pro 
        35                  40                  45              


Ser Arg Pro Arg Ala Ala Pro Glu Thr Ser Gly Gly Asp Thr Ala Gly 
    50                  55                  60                  


Ala Gly Arg Cys Gly Gly Arg Arg Ala Ala Lys Leu Gly Pro Gly Arg 
65                  70                  75                  80  


Arg Gly Trp Trp Ala Leu Leu Ala Leu Gln Leu His Leu Leu Arg Ala 
                85                  90                  95      


Leu Ala Gln Asp Asp Val Ala Pro Tyr Phe Lys Thr Glu Pro Gly Leu 
            100                 105                 110         


Pro Gln Ile His Leu Glu Gly Asn Arg Leu Val Leu Thr Cys Leu Ala 
        115                 120                 125             


Glu Gly Ser Trp Pro Leu Glu Phe Lys Trp Met Arg Asp Asp Ser Glu 
    130                 135                 140                 


Leu Thr Thr Tyr Ser Ser Glu Tyr Lys Tyr Ile Ile Pro Ser Leu Gln 
145                 150                 155                 160 


Lys Leu Asp Ala Gly Phe Tyr Arg Cys Val Val Arg Asn Arg Met Gly 
                165                 170                 175     


Ala Leu Leu Gln Arg Lys Ser Glu Val Gln Val Ala Tyr Met Gly Ser 
            180                 185                 190         


Phe Met Asp Thr Asp Gln Arg Lys Thr Val Ser Gln Gly Arg Ala Ala 
        195                 200                 205             


Ile Leu Asn Leu Leu Pro Ile Thr Ser Tyr Pro Arg Pro Gln Val Thr 
    210                 215                 220                 


Trp Phe Arg Glu Gly His Lys Ile Ile Pro Ser Asn Arg Ile Ala Ile 
225                 230                 235                 240 


Thr Leu Glu Asn Gln Leu Val Ile Leu Ala Thr Thr Thr Ser Asp Ala 
                245                 250                 255     


Gly Ala Tyr Tyr Val Gln Ala Val Asn Glu Lys Asn Gly Glu Asn Lys 
            260                 265                 270         


Thr Ser Pro Phe Ile His Leu Ser Ile Ala Arg Asp Val Gly Thr Pro 
        275                 280                 285             


Glu Thr Met Ala Pro Thr Ile Val Val Pro Pro Gly Asn Arg Ser Val 
    290                 295                 300                 


Val Ala Gly Ser Ser Glu Thr Thr Leu Glu Cys Ile Ala Ser Ala Arg 
305                 310                 315                 320 


Pro Val Glu Asp Leu Ser Val Thr Trp Lys Arg Asn Gly Val Arg Ile 
                325                 330                 335     


Thr Ser Gly Leu His Ser Phe Gly Arg Arg Leu Thr Ile Ser Asn Pro 
            340                 345                 350         


Thr Ser Ala Asp Thr Gly Pro Tyr Val Cys Glu Ala Ala Leu Pro Gly 
        355                 360                 365             


Ser Ala Phe Glu Pro Ala Arg Ala Thr Ala Phe Leu Phe Ile Ile Glu 
    370                 375                 380                 


Pro Pro Tyr Phe Thr Ala Glu Pro Glu Ser Arg Ile Ser Ala Glu Val 
385                 390                 395                 400 


Glu Glu Thr Val Asp Ile Gly Cys Gln Ala Met Gly Val Pro Leu Pro 
                405                 410                 415     


Thr Leu Gln Trp Tyr Lys Asp Ala Ile Ser Ile Ser Arg Leu Gln Asn 
            420                 425                 430         


Pro Arg Tyr Lys Val Leu Ala Ser Gly Gly Leu Arg Ile Gln Lys Leu 
        435                 440                 445             


Arg Pro Glu Asp Ser Gly Ile Phe Gln Cys Phe Ala Ser Asn Glu Gly 
    450                 455                 460                 


Gly Glu Ile Gln Thr His Thr Tyr Leu Asp Val Thr Asn Ile Ala Pro 
465                 470                 475                 480 


Val Phe Thr Gln Arg Pro Val Asp Thr Thr Val Thr Asp Gly Met Thr 
                485                 490                 495     


Ala Ile Leu Arg Cys Glu Val Ser Gly Ala Pro Lys Pro Ala Ile Thr 
            500                 505                 510         


Trp Lys Arg Glu Asn His Ile Leu Ala Ser Gly Ser Val Arg Ile Pro 
        515                 520                 525             


Arg Phe Met Leu Leu Glu Ser Gly Gly Leu Gln Ile Ala Pro Val Phe 
    530                 535                 540                 


Ile Gln Asp Ala Gly Asn Tyr Thr Cys Tyr Ala Ala Asn Thr Glu Gly 
545                 550                 555                 560 


Ser Leu Asn Ala Ser Ala Thr Leu Thr Val Trp Asn Arg Thr Ser Ile 
                565                 570                 575     


Val His Pro Pro Glu Asp His Val Val Ile Lys Gly Thr Thr Ala Thr 
            580                 585                 590         


Leu His Cys Gly Ala Thr His Asp Pro Arg Val Ser Leu Arg Tyr Val 
        595                 600                 605             


Trp Lys Lys Asp Asn Val Ala Leu Thr Pro Ser Ser Thr Ser Arg Ile 
    610                 615                 620                 


Val Val Glu Lys Asp Gly Ser Leu Leu Ile Ser Gln Thr Trp Ser Gly 
625                 630                 635                 640 


Asp Ile Gly Asp Tyr Ser Cys Glu Ile Val Ser Glu Gly Gly Asn Asp 
                645                 650                 655     


Ser Arg Met Ala Arg Leu Glu Val Ile Glu Leu Pro His Ser Pro Gln 
            660                 665                 670         


Asn Leu Leu Val Ser Pro Asn Ser Ser His Ser His Ala Val Val Leu 
        675                 680                 685             


Ser Trp Val Arg Pro Phe Asp Gly Asn Ser Pro Ile Leu Tyr Tyr Ile 
    690                 695                 700                 


Val Glu Leu Ser Glu Asn Asn Ser Pro Trp Lys Val His Leu Ser Asn 
705                 710                 715                 720 


Val Gly Pro Glu Met Thr Gly Val Thr Val Ser Gly Leu Thr Pro Ala 
                725                 730                 735     


Arg Thr Tyr Gln Phe Arg Val Cys Ala Val Asn Glu Val Gly Arg Gly 
            740                 745                 750         


Gln Tyr Ser Ala Glu Thr Ser Arg Leu Met Leu Pro Glu Glu Pro Pro 
        755                 760                 765             


Ser Ala Pro Pro Lys Asn Ile Val Ala Ser Gly Arg Thr Asn Gln Ser 
    770                 775                 780                 


Ile Met Val Gln Trp Gln Pro Pro Pro Glu Thr Glu His Asn Gly Val 
785                 790                 795                 800 


Leu Arg Gly Tyr Ile Leu Arg Tyr Arg Leu Ala Gly Leu Pro Gly Glu 
                805                 810                 815     


Tyr Gln Gln Arg Asn Ile Thr Ser Pro Glu Val Asn Tyr Cys Leu Val 
            820                 825                 830         


Thr Asp Leu Ile Ile Trp Thr Gln Tyr Glu Ile Gln Val Ala Ala Tyr 
        835                 840                 845             


Asn Gly Ala Gly Leu Gly Val Phe Ser Arg Ala Val Thr Glu Tyr Thr 
    850                 855                 860                 


Leu Gln Gly Val Pro Thr Ala Pro Pro Gln Asn Val Gln Thr Glu Ala 
865                 870                 875                 880 


Val Asn Ser Thr Thr Ile Gln Phe Leu Trp Asn Pro Pro Pro Gln Gln 
                885                 890                 895     


Phe Ile Asn Gly Ile Asn Gln Gly Tyr Lys Leu Leu Ala Trp Pro Ala 
            900                 905                 910         


Asp Ala Pro Glu Ala Val Thr Val Val Thr Ile Ala Pro Asp Phe His 
        915                 920                 925             


Gly Val His His Gly His Ile Thr Asn Leu Lys Lys Phe Thr Ala Tyr 
    930                 935                 940                 


Phe Thr Ser Val Leu Cys Phe Thr Thr Pro Gly Asp Gly Pro Pro Ser 
945                 950                 955                 960 


Thr Pro Gln Leu Val Trp Thr Gln Glu Asp Lys Pro Gly Ala Val Gly 
                965                 970                 975     


His Leu Ser Phe Thr Glu Ile Leu Asp Thr Ser Leu Lys Val Ser Trp 
            980                 985                 990         


Gln Glu Pro Leu Glu Lys Asn Gly  Ile Ile Thr Gly Tyr  Gln Ile Ser 
        995                 1000                 1005             


Trp Glu  Val Tyr Gly Arg Asn  Asp Ser Arg Leu Thr  His Thr Leu 
    1010                 1015                 1020             


Asn Ser  Thr Thr His Glu Tyr  Lys Ile Gln Gly Leu  Ser Ser Leu 
    1025                 1030                 1035             


Thr Thr  Tyr Thr Ile Asp Val  Ala Ala Val Thr Ala  Val Gly Thr 
    1040                 1045                 1050             


Gly Leu  Val Thr Ser Ser Thr  Ile Ser Ser Gly Val  Pro Pro Asp 
    1055                 1060                 1065             


Leu Pro  Gly Ala Pro Ser Asn  Leu Val Ile Ser Asn  Ile Ser Pro 
    1070                 1075                 1080             


Arg Ser  Ala Thr Leu Gln Phe  Arg Pro Gly Tyr Asp  Gly Lys Thr 
    1085                 1090                 1095             


Ser Ile  Ser Arg Trp Ile Val  Glu Gly Gln Val Gly  Ala Ile Gly 
    1100                 1105                 1110             


Asp Glu  Glu Glu Trp Val Thr  Leu Tyr Glu Glu Glu  Asn Glu Pro 
    1115                 1120                 1125             


Asp Ala  Gln Met Leu Glu Ile  Pro Asn Leu Thr Pro  Tyr Thr His 
    1130                 1135                 1140             


Tyr Arg  Phe Arg Met Lys Gln  Val Asn Ile Val Gly  Pro Ser Pro 
    1145                 1150                 1155             


Tyr Ser  Pro Ser Ser Arg Val  Ile Gln Thr Leu Gln  Ala Pro Pro 
    1160                 1165                 1170             


Asp Val  Ala Pro Thr Ser Val  Thr Val Arg Thr Ala  Ser Glu Thr 
    1175                 1180                 1185             


Ser Leu  Arg Leu Arg Trp Val  Pro Leu Pro Asp Ser  Gln Tyr Asn 
    1190                 1195                 1200             


Gly Asn  Pro Glu Ser Val Gly  Tyr Arg Ile Lys Tyr  Trp Arg Ser 
    1205                 1210                 1215             


Asp Leu  Gln Ser Ser Ala Val  Ala Gln Val Val Ser  Asp Arg Leu 
    1220                 1225                 1230             


Glu Arg  Glu Phe Thr Ile Glu  Glu Leu Glu Glu Trp  Met Glu Tyr 
    1235                 1240                 1245             


Glu Leu  Gln Met Gln Ala Phe  Asn Ala Val Gly Ala  Gly Pro Trp 
    1250                 1255                 1260             


Ser Glu  Val Val Arg Gly Arg  Thr Arg Glu Ser Val  Pro Ser Ala 
    1265                 1270                 1275             


Ala Pro  Glu Asn Val Ser Ala  Glu Ala Val Ser Ser  Thr Gln Ile 
    1280                 1285                 1290             


Leu Leu  Thr Trp Thr Ser Val  Pro Glu Gln Asp Gln  Asn Gly Leu 
    1295                 1300                 1305             


Ile Leu  Gly Tyr Lys Ile Leu  Phe Arg Ala Lys Asp  Leu Asp Pro 
    1310                 1315                 1320             


Glu Pro  Arg Ser His Ile Val  Arg Gly Asn His Thr  Gln Ser Ala 
    1325                 1330                 1335             


Leu Leu  Ala Gly Leu Arg Lys  Phe Val Leu Tyr Glu  Leu Gln Val 
    1340                 1345                 1350             


Leu Ala  Phe Thr Arg Ile Gly  Asn Gly Val Pro Ser  Thr Pro Leu 
    1355                 1360                 1365             


Ile Leu  Glu Arg Thr Lys Asp  Asp Ala Pro Gly Pro  Pro Val Arg 
    1370                 1375                 1380             


Leu Val  Phe Pro Glu Val Arg  Leu Thr Ser Val Arg  Ile Val Trp 
    1385                 1390                 1395             


Gln Pro  Pro Glu Glu Pro Asn  Gly Ile Ile Leu Gly  Tyr Gln Ile 
    1400                 1405                 1410             


Ala Tyr  Arg Leu Ala Ser Ser  Ser Pro His Thr Phe  Thr Thr Val 
    1415                 1420                 1425             


Glu Val  Gly Ala Thr Val Arg  Gln Phe Thr Ala Thr  Asp Leu Ala 
    1430                 1435                 1440             


Pro Glu  Ser Ala Tyr Ile Phe  Arg Leu Ser Ala Lys  Thr Arg Gln 
    1445                 1450                 1455             


Gly Trp  Gly Glu Pro Leu Glu  Ala Thr Val Ile Thr  Thr Glu Lys 
    1460                 1465                 1470             


Arg Glu  Arg Pro Ala Pro Pro  Arg Glu Leu Leu Val  Pro Gln Ala 
    1475                 1480                 1485             


Glu Val  Thr Ala Arg Ser Leu  Arg Leu Gln Trp Val  Pro Gly Ser 
    1490                 1495                 1500             


Asp Gly  Ala Ser Pro Ile Arg  Tyr Phe Thr Met Gln  Val Arg Glu 
    1505                 1510                 1515             


Leu Pro  Arg Gly Glu Trp Gln  Thr Tyr Ser Ser Ser  Ile Ser His 
    1520                 1525                 1530             


Glu Ala  Thr Ala Cys Val Val  Asp Arg Leu Arg Pro  Phe Thr Ser 
    1535                 1540                 1545             


Tyr Lys  Leu Arg Leu Lys Ala  Thr Asn Asp Ile Gly  Asp Ser Asp 
    1550                 1555                 1560             


Phe Ser  Ser Glu Thr Glu Ala  Val Thr Thr Leu Gln  Asp Val Pro 
    1565                 1570                 1575             


Gly Glu  Pro Pro Gly Ser Val  Ser Ala Thr Pro His  Thr Thr Ser 
    1580                 1585                 1590             


Ser Val  Leu Ile Gln Trp Gln  Pro Pro Arg Asp Glu  Ser Leu Asn 
    1595                 1600                 1605             


Gly Leu  Leu Gln Gly Tyr Arg  Ile Tyr Tyr Arg Glu  Leu Glu Tyr 
    1610                 1615                 1620             


Glu Ala  Gly Ser Gly Thr Glu  Ala Lys Thr Leu Lys  Asn Pro Ile 
    1625                 1630                 1635             


Ala Leu  His Ala Glu Leu Thr  Ala Gln Ser Ser Phe  Lys Thr Val 
    1640                 1645                 1650             


Asn Ser  Ser Ser Thr Ser Thr  Met Cys Glu Leu Thr  His Leu Lys 
    1655                 1660                 1665             


Lys Tyr  Arg Arg Tyr Glu Val  Ile Met Thr Ala Tyr  Asn Ile Ile 
    1670                 1675                 1680             


Gly Glu  Ser Pro Ala Ser Ala  Pro Val Glu Val Phe  Val Gly Glu 
    1685                 1690                 1695             


Ala Ala  Pro Ala Met Ala Pro  Gln Asn Val Gln Val  Thr Pro Leu 
    1700                 1705                 1710             


Thr Ala  Ser Gln Leu Glu Val  Thr Trp Asp Pro Pro  Pro Pro Glu 
    1715                 1720                 1725             


Ser Gln  Asn Gly Asn Ile Gln  Gly Tyr Lys Ile Tyr  Tyr Trp Glu 
    1730                 1735                 1740             


Ala Asp  Ser Gln Asn Glu Thr  Glu Lys Met Lys Val  Leu Phe Leu 
    1745                 1750                 1755             


Pro Glu  Pro Val Val Arg Leu  Lys Asn Leu Thr Ser  His Thr Lys 
    1760                 1765                 1770             


Tyr Leu  Val Ser Ile Ser Ala  Phe Asn Ala Ala Gly  Asp Gly Pro 
    1775                 1780                 1785             


Lys Ser  Asp Pro Gln Gln Gly  Arg Thr His Gln Ala  Ala Pro Gly 
    1790                 1795                 1800             


Ala Pro  Ser Phe Leu Ala Phe  Ser Glu Ile Thr Ser  Thr Thr Leu 
    1805                 1810                 1815             


Asn Val  Ser Trp Gly Glu Pro  Ala Ala Ala Asn Gly  Ile Leu Gln 
    1820                 1825                 1830             


Gly Tyr  Arg Val Val Tyr Glu  Pro Leu Ala Pro Val  Gln Gly Val 
    1835                 1840                 1845             


Ser Lys  Val Val Thr Val Glu  Val Arg Gly Asn Trp  Gln Arg Trp 
    1850                 1855                 1860             


Leu Lys  Val Arg Asp Leu Thr  Lys Gly Val Thr Tyr  Phe Phe Arg 
    1865                 1870                 1875             


Val Gln  Ala Arg Thr Ile Thr  Tyr Gly Pro Glu Leu  Gln Ala Asn 
    1880                 1885                 1890             


Ile Thr  Ala Gly Pro Ala Glu  Gly Ser Pro Gly Ser  Pro Arg Asp 
    1895                 1900                 1905             


Val Leu  Val Thr Lys Ser Ala  Ser Glu Leu Thr Leu  Gln Trp Thr 
    1910                 1915                 1920             


Glu Gly  His Ser Gly Asp Thr  Pro Thr Thr Gly Tyr  Val Ile Glu 
    1925                 1930                 1935             


Ala Arg  Pro Ser Asp Glu Gly  Leu Trp Asp Met Phe  Val Lys Asp 
    1940                 1945                 1950             


Ile Pro  Arg Ser Ala Thr Ser  Tyr Thr Leu Ser Leu  Asp Lys Leu 
    1955                 1960                 1965             


Arg Gln  Gly Val Thr Tyr Glu  Phe Arg Val Val Ala  Val Asn Glu 
    1970                 1975                 1980             


Ala Gly  Tyr Gly Glu Pro Ser  Asn Pro Ser Thr Ala  Val Ser Ala 
    1985                 1990                 1995             


Gln Val  Glu Ala Pro Phe Tyr  Glu Glu Trp Trp Phe  Leu Leu Val 
    2000                 2005                 2010             


Met Ala  Leu Ser Ser Leu Ile  Val Ile Leu Leu Val  Val Phe Ala 
    2015                 2020                 2025             


Leu Val  Leu His Gly Gln Asn  Lys Lys Tyr Lys Asn  Cys Ser Thr 
    2030                 2035                 2040             


Gly Lys  Gly Ile Ser Thr Met  Glu Glu Ser Val Thr  Leu Asp Asn 
    2045                 2050                 2055             


Gly Gly  Phe Ala Ala Leu Glu  Leu Ser Ser Arg His  Leu Asn Val 
    2060                 2065                 2070             


Lys Ser  Thr Phe Ser Lys Lys  Asn Gly Thr Arg Ser  Pro Pro Arg 
    2075                 2080                 2085             


Pro Ser  Pro Gly Gly Leu His  Tyr Ser Asp Glu Asp  Ile Cys Asn 
    2090                 2095                 2100             


Lys Tyr  Asn Gly Ala Val Leu  Thr Glu Ser Val Ser  Leu Lys Glu 
    2105                 2110                 2115             


Lys Ser  Ala Asp Ala Ser Glu  Ser Glu Ala Thr Asp  Ser Asp Tyr 
    2120                 2125                 2130             


Glu Asp  Ala Leu Pro Lys His  Ser Phe Val Asn His  Tyr Met Ser 
    2135                 2140                 2145             


Asp Pro  Thr Tyr Tyr Asn Ser  Trp Lys Arg Arg Ala  Gln Gly Arg 
    2150                 2155                 2160             


Ala Pro  Ala Pro His Arg Tyr  Glu Ala Val Ala Gly  Ser Glu Ala 
    2165                 2170                 2175             


Gly Ala  Gln Leu His Pro Val  Ile Thr Thr Gln Ser  Ala Gly Gly 
    2180                 2185                 2190             


Val Tyr  Thr Pro Ala Gly Pro  Gly Ala Arg Thr Pro  Leu Thr Gly 
    2195                 2200                 2205             


Phe Ser  Ser Phe Val 
    2210             


<210>  6110
<211>  862
<212>  PRT
<213>  Homo sapiens

<400>  6110

Met His Ser Ser Trp Ile Pro Arg Gly Asn Tyr Ile Glu Ser Asn Arg 
1               5                   10                  15      


Asp Asp Cys Thr Val Ser Leu Ile Tyr Ala Val His Leu Lys Lys Ser 
            20                  25                  30          


Gly Tyr Val Phe Phe Glu Tyr Gln Tyr Val Asp Asn Asn Ile Phe Phe 
        35                  40                  45              


Glu Phe Phe Ile Gln Asn Asp Gln Cys Gln Glu Met Asp Thr Thr Thr 
    50                  55                  60                  


Asp Lys Trp Val Lys Leu Thr Asp Asn Gly Glu Trp Gly Ser His Ser 
65                  70                  75                  80  


Val Met Leu Lys Ser Gly Thr Asn Ile Leu Tyr Trp Arg Thr Thr Gly 
                85                  90                  95      


Ile Leu Met Gly Ser Lys Ala Val Lys Pro Val Leu Val Lys Asn Ile 
            100                 105                 110         


Thr Ile Glu Gly Val Ala Tyr Thr Ser Glu Cys Phe Pro Cys Lys Pro 
        115                 120                 125             


Gly Thr Phe Ser Asn Lys Pro Gly Ser Phe Asn Cys Gln Val Cys Pro 
    130                 135                 140                 


Arg Asn Thr Tyr Ser Glu Lys Gly Ala Lys Glu Cys Ile Arg Cys Lys 
145                 150                 155                 160 


Asp Asp Ser Gln Phe Ser Glu Glu Gly Ser Ser Glu Cys Thr Glu Arg 
                165                 170                 175     


Pro Pro Cys Thr Thr Lys Asp Tyr Phe Gln Ile His Thr Pro Cys Asp 
            180                 185                 190         


Glu Glu Gly Lys Thr Gln Ile Met Tyr Lys Trp Ile Glu Pro Lys Ile 
        195                 200                 205             


Cys Arg Glu Asp Leu Thr Asp Ala Ile Arg Leu Pro Pro Ser Gly Glu 
    210                 215                 220                 


Lys Lys Asp Cys Pro Pro Cys Asn Pro Gly Phe Tyr Asn Asn Gly Ser 
225                 230                 235                 240 


Ser Ser Cys His Pro Cys Pro Pro Gly Thr Phe Ser Asp Gly Thr Lys 
                245                 250                 255     


Glu Cys Arg Pro Cys Pro Ala Gly Thr Glu Pro Ala Leu Gly Phe Glu 
            260                 265                 270         


Tyr Lys Trp Trp Asn Val Leu Pro Gly Asn Met Lys Thr Ser Cys Phe 
        275                 280                 285             


Asn Val Gly Asn Ser Lys Cys Asp Gly Met Asn Gly Trp Glu Val Ala 
    290                 295                 300                 


Gly Asp His Ile Gln Ser Gly Ala Gly Gly Ser Asp Asn Asp Tyr Leu 
305                 310                 315                 320 


Ile Leu Asn Leu His Ile Pro Gly Phe Lys Pro Pro Thr Ser Met Thr 
                325                 330                 335     


Gly Ala Thr Gly Ser Glu Leu Gly Arg Ile Thr Phe Val Phe Glu Thr 
            340                 345                 350         


Leu Cys Ser Ala Asp Cys Val Leu Tyr Phe Met Val Asp Ile Asn Arg 
        355                 360                 365             


Lys Ser Thr Asn Val Val Glu Ser Trp Gly Gly Thr Lys Glu Lys Gln 
    370                 375                 380                 


Ala Tyr Thr His Ile Ile Phe Lys Asn Ala Thr Phe Thr Phe Thr Trp 
385                 390                 395                 400 


Ala Phe Gln Arg Thr Asn Gln Gly Gln Asp Asn Arg Arg Phe Ile Asn 
                405                 410                 415     


Asp Met Val Lys Ile Tyr Ser Ile Thr Ala Thr Asn Ala Val Asp Gly 
            420                 425                 430         


Val Ala Ser Ser Cys Arg Ala Cys Ala Leu Gly Ser Glu Gln Ser Gly 
        435                 440                 445             


Ser Ser Cys Val Pro Cys Pro Pro Gly His Tyr Ile Glu Lys Glu Thr 
    450                 455                 460                 


Asn Gln Cys Lys Glu Cys Pro Pro Asp Thr Tyr Leu Ser Ile His Gln 
465                 470                 475                 480 


Val Tyr Gly Lys Glu Ala Cys Ile Pro Cys Gly Pro Gly Ser Lys Asn 
                485                 490                 495     


Asn Gln Asp His Ser Val Cys Tyr Ser Asp Cys Phe Phe Tyr His Glu 
            500                 505                 510         


Lys Glu Asn Gln Ser Leu His Tyr Asp Phe Ser Asn Leu Ser Ser Val 
        515                 520                 525             


Gly Ser Leu Met Asn Gly Pro Ser Phe Thr Ser Lys Gly Thr Lys Tyr 
    530                 535                 540                 


Phe His Phe Phe Asn Ile Ser Leu Cys Gly His Glu Gly Lys Lys Met 
545                 550                 555                 560 


Ala Leu Cys Thr Asn Asn Ile Thr Asp Phe Thr Val Lys Glu Ile Val 
                565                 570                 575     


Ala Gly Ser Asp Asp Tyr Thr Asn Leu Val Gly Ala Phe Val Cys Gln 
            580                 585                 590         


Ser Thr Ile Ile Pro Ser Glu Ser Lys Gly Phe Arg Ala Ala Leu Ser 
        595                 600                 605             


Ser Gln Ser Ile Ile Leu Ala Asp Thr Phe Ile Gly Val Thr Val Glu 
    610                 615                 620                 


Thr Thr Leu Lys Asn Ile Asn Ile Lys Glu Asp Met Phe Pro Val Pro 
625                 630                 635                 640 


Thr Ser Gln Ile Pro Asp Val His Phe Phe Tyr Lys Ser Ser Thr Ala 
                645                 650                 655     


Thr Thr Ser Cys Ile Asn Gly Arg Ser Thr Ala Val Lys Met Arg Cys 
            660                 665                 670         


Asn Pro Thr Lys Ser Gly Ala Gly Val Ile Ser Val Pro Ser Lys Cys 
        675                 680                 685             


Pro Ala Gly Thr Cys Asp Gly Cys Thr Phe Tyr Phe Leu Trp Glu Ser 
    690                 695                 700                 


Ala Glu Ala Cys Pro Leu Cys Thr Glu His Asp Phe His Glu Ile Glu 
705                 710                 715                 720 


Gly Ala Cys Lys Arg Gly Phe Gln Glu Thr Leu Tyr Val Trp Asn Glu 
                725                 730                 735     


Pro Lys Trp Cys Ile Lys Gly Ile Ser Leu Pro Glu Lys Lys Leu Ala 
            740                 745                 750         


Thr Cys Glu Thr Val Asp Phe Trp Leu Lys Val Gly Ala Gly Val Gly 
        755                 760                 765             


Ala Phe Thr Ala Val Leu Leu Val Ala Leu Thr Cys Tyr Phe Trp Lys 
    770                 775                 780                 


Lys Asn Gln Lys Leu Glu Tyr Lys Tyr Ser Lys Leu Val Met Thr Thr 
785                 790                 795                 800 


Asn Ser Lys Glu Cys Glu Leu Pro Ala Ala Asp Ser Cys Ala Ile Met 
                805                 810                 815     


Glu Gly Glu Asp Asn Glu Glu Glu Val Val Tyr Ser Asn Lys Gln Ser 
            820                 825                 830         


Leu Leu Gly Lys Leu Lys Ser Leu Ala Thr Lys Glu Lys Glu Asp His 
        835                 840                 845             


Phe Glu Ser Val Gln Leu Lys Thr Ser Arg Ser Pro Asn Ile 
    850                 855                 860         


<210>  6111
<211>  777
<212>  PRT
<213>  Homo sapiens

<400>  6111

Met Asn Ala Asn Lys Asp Glu Arg Leu Lys Ala Arg Ser Gln Asp Phe 
1               5                   10                  15      


His Leu Phe Pro Ala Leu Met Met Leu Ser Met Thr Met Leu Phe Leu 
            20                  25                  30          


Pro Val Thr Gly Thr Leu Lys Gln Asn Ile Pro Arg Leu Lys Leu Thr 
        35                  40                  45              


Tyr Lys Asp Leu Leu Leu Ser Asn Ser Cys Ile Pro Phe Leu Gly Ser 
    50                  55                  60                  


Ser Glu Gly Leu Asp Phe Gln Thr Leu Leu Leu Asp Glu Glu Arg Gly 
65                  70                  75                  80  


Arg Leu Leu Leu Gly Ala Lys Asp His Ile Phe Leu Leu Ser Leu Val 
                85                  90                  95      


Asp Leu Asn Lys Asn Phe Lys Lys Ile Tyr Trp Pro Ala Ala Lys Glu 
            100                 105                 110         


Arg Val Glu Leu Cys Lys Leu Ala Gly Lys Asp Ala Asn Thr Glu Cys 
        115                 120                 125             


Ala Asn Phe Ile Arg Val Leu Gln Pro Tyr Asn Lys Thr His Ile Tyr 
    130                 135                 140                 


Val Cys Gly Thr Gly Ala Phe His Pro Ile Cys Gly Tyr Ile Asp Leu 
145                 150                 155                 160 


Gly Val Tyr Lys Glu Asp Ile Ile Phe Lys Leu Asp Thr His Asn Leu 
                165                 170                 175     


Glu Ser Gly Arg Leu Lys Cys Pro Phe Asp Pro Gln Gln Pro Phe Ala 
            180                 185                 190         


Ser Val Met Thr Asp Glu Tyr Leu Tyr Ser Gly Thr Ala Ser Asp Phe 
        195                 200                 205             


Leu Gly Lys Asp Thr Ala Phe Thr Arg Ser Leu Gly Pro Thr His Asp 
    210                 215                 220                 


His His Tyr Ile Arg Thr Asp Ile Ser Glu His Tyr Trp Leu Asn Gly 
225                 230                 235                 240 


Ala Lys Phe Ile Gly Thr Phe Phe Ile Pro Asp Thr Tyr Asn Pro Asp 
                245                 250                 255     


Asp Asp Lys Ile Tyr Phe Phe Phe Arg Glu Ser Ser Gln Glu Gly Ser 
            260                 265                 270         


Thr Ser Asp Lys Thr Ile Leu Ser Arg Val Gly Arg Val Cys Lys Asn 
        275                 280                 285             


Asp Val Gly Gly Gln Arg Ser Leu Ile Asn Lys Trp Thr Thr Phe Leu 
    290                 295                 300                 


Lys Ala Arg Leu Ile Cys Ser Ile Pro Gly Ser Asp Gly Ala Asp Thr 
305                 310                 315                 320 


Tyr Phe Asp Glu Leu Gln Asp Ile Tyr Leu Leu Pro Thr Arg Asp Glu 
                325                 330                 335     


Arg Asn Pro Val Val Tyr Gly Val Phe Thr Thr Thr Ser Ser Ile Phe 
            340                 345                 350         


Lys Gly Ser Ala Val Cys Val Tyr Ser Met Ala Asp Ile Arg Ala Val 
        355                 360                 365             


Phe Asn Gly Pro Tyr Ala His Lys Glu Ser Ala Asp His Arg Trp Val 
    370                 375                 380                 


Gln Tyr Asp Gly Arg Ile Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser 
385                 390                 395                 400 


Lys Thr Tyr Asp Pro Leu Ile Lys Ser Thr Arg Asp Phe Pro Asp Asp 
                405                 410                 415     


Val Ile Ser Phe Ile Lys Arg His Ser Val Met Tyr Lys Ser Val Tyr 
            420                 425                 430         


Pro Val Ala Gly Gly Pro Thr Phe Lys Arg Ile Asn Val Asp Tyr Arg 
        435                 440                 445             


Leu Thr Gln Ile Val Val Asp His Val Ile Ala Glu Asp Gly Gln Tyr 
    450                 455                 460                 


Asp Val Met Phe Leu Gly Thr Asp Ile Gly Thr Val Leu Lys Val Val 
465                 470                 475                 480 


Ser Ile Ser Lys Glu Lys Trp Asn Met Glu Glu Val Val Leu Glu Glu 
                485                 490                 495     


Leu Gln Ile Phe Lys His Ser Ser Ile Ile Leu Asn Met Glu Leu Ser 
            500                 505                 510         


Leu Lys Gln Gln Gln Leu Tyr Ile Gly Ser Arg Asp Gly Leu Val Gln 
        515                 520                 525             


Leu Ser Leu His Arg Cys Asp Thr Tyr Gly Lys Ala Cys Ala Asp Cys 
    530                 535                 540                 


Cys Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Asn Ala Cys Ser 
545                 550                 555                 560 


Arg Tyr Ala Pro Thr Ser Lys Arg Arg Ala Arg Arg Gln Asp Val Lys 
                565                 570                 575     


Tyr Gly Asp Pro Ile Thr Gln Cys Trp Asp Ile Glu Asp Ser Ile Ser 
            580                 585                 590         


His Glu Thr Ala Asp Glu Lys Val Ile Phe Gly Ile Glu Phe Asn Ser 
        595                 600                 605             


Thr Phe Leu Glu Cys Ile Pro Lys Ser Gln Gln Ala Thr Ile Lys Trp 
    610                 615                 620                 


Tyr Ile Gln Arg Ser Gly Asp Glu His Arg Glu Glu Leu Lys Pro Asp 
625                 630                 635                 640 


Glu Arg Ile Ile Lys Thr Glu Tyr Gly Leu Leu Ile Arg Ser Leu Gln 
                645                 650                 655     


Lys Lys Asp Ser Gly Met Tyr Tyr Cys Lys Ala Gln Glu His Thr Phe 
            660                 665                 670         


Ile His Thr Ile Val Lys Leu Thr Leu Asn Val Ile Glu Asn Glu Gln 
        675                 680                 685             


Met Glu Asn Thr Gln Arg Ala Glu His Glu Glu Gly Lys Val Lys Asp 
    690                 695                 700                 


Leu Leu Ala Glu Ser Arg Leu Arg Tyr Lys Asp Tyr Ile Gln Ile Leu 
705                 710                 715                 720 


Ser Ser Pro Asn Phe Ser Leu Asp Gln Tyr Cys Glu Gln Met Trp His 
                725                 730                 735     


Arg Glu Lys Arg Arg Gln Arg Asn Lys Gly Gly Pro Lys Trp Lys His 
            740                 745                 750         


Met Gln Glu Met Lys Lys Lys Arg Asn Arg Arg His His Arg Asp Leu 
        755                 760                 765             


Asp Glu Leu Pro Arg Ala Val Ala Thr 
    770                 775         


<210>  6112
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  6112

Met Ala Gly Pro Ala Ala Ala Phe Arg Arg Leu Gly Ala Leu Ser Gly 
1               5                   10                  15      


Ala Ala Ala Leu Gly Phe Ala Ser Tyr Gly Ala His Gly Ala Gln Phe 
            20                  25                  30          


Pro Asp Ala Tyr Gly Lys Glu Leu Phe Asp Lys Ala Asn Lys His His 
        35                  40                  45              


Phe Leu His Ser Leu Ala Leu Leu Gly Val Pro His Cys Arg Lys Pro 
    50                  55                  60                  


Leu Trp Ala Gly Leu Leu Leu Ala Ser Gly Thr Thr Leu Phe Cys Thr 
65                  70                  75                  80  


Ser Phe Tyr Tyr Gln Ala Leu Ser Gly Asp Pro Ser Ile Gln Thr Leu 
                85                  90                  95      


Ala Pro Ala Gly Gly Thr Leu Leu Leu Leu Gly Trp Leu Ala Leu Ala 
            100                 105                 110         


Leu 
    


<210>  6113
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  6113

Met Gln Pro Thr Ala Thr Met Ala Thr Ala Ala Thr Thr Thr Thr Thr 
1               5                   10                  15      


Thr Thr Ala Thr Val Ala Leu Thr Thr Ser Trp Asp Asn Ala Thr Gly 
            20                  25                  30          


Arg Pro Thr Ala Glu Pro Asp Pro Ile Leu Asp Asn Tyr Val Leu Leu 
        35                  40                  45              


Val Val Val Met Ser Leu Phe Val Gly Gly Thr Leu Val Val Leu Ser 
    50                  55                  60                  


Gly Val Leu Leu Leu Cys Lys Arg Cys Trp Asp Val His Gln Arg Leu 
65                  70                  75                  80  


Asn Arg Ala Met Glu Glu Ala Glu Lys Thr Thr Thr Thr Tyr Leu Asp 
                85                  90                  95      


Asn Gly Thr His Pro Ala Gln Asp Pro Asp Phe Arg Gly Glu Asp Pro 
            100                 105                 110         


Glu Cys Gln Asp Ala Glu Thr Glu Arg Phe Leu Ser Thr Ser Ser Thr 
        115                 120                 125             


Gly Arg Arg Val Ser Phe Asn Glu Ala Ala Leu Phe Glu Gln Ser Arg 
    130                 135                 140                 


Lys Thr Gln Asp Lys Gly Arg Arg Tyr Thr Leu Thr Glu Gly Asp Phe 
145                 150                 155                 160 


His His Leu Lys Asn Ala Arg Leu Thr His Leu His Leu Pro Pro Leu 
                165                 170                 175     


Lys Ile Val Thr Ile His Glu Cys Asp Ser Gly Glu Ala Ser Ser Ala 
            180                 185                 190         


Thr Thr Pro His Pro Ala Thr Ser Pro Lys Ala Thr Leu Ala Ile Phe 
        195                 200                 205             


Gln Pro Pro Gly Lys Ala Leu Thr Gly Arg Ser Val Gly Pro Ser Ser 
    210                 215                 220                 


Ala Leu Pro Gly Asp Pro Tyr Asn Ser Ala Ala Gly Ala Thr Asp Phe 
225                 230                 235                 240 


Ala Glu Ile Ser Pro Ser Ala Ser Ser Asp Ser Gly Glu Gly Thr Ser 
                245                 250                 255     


Leu Asp Ala Gly Thr Arg Ser Thr Lys Ala Gly Gly Pro Gly Ala Ala 
            260                 265                 270         


Ala Gly Pro Gly Glu Ala Gly Pro Gly Ser Gly Ala Gly Thr Val Leu 
        275                 280                 285             


Gln Phe Leu Thr Arg Leu Arg Arg His Ala Ser Leu Asp Gly Ala Ser 
    290                 295                 300                 


Pro Tyr Phe Lys Val Lys Lys Trp Lys Leu Glu Pro Ser Gln Arg Ala 
305                 310                 315                 320 


Ala Ser Leu Asp Thr Arg Gly Ser Pro Lys Arg His His Phe Gln Arg 
                325                 330                 335     


Gln Arg Ala Ala Ser Glu Ser Thr Glu Gln Glu Glu Gly Asp Ala Pro 
            340                 345                 350         


Gln Glu Asp Phe Ile Gln Tyr Ile Ala Arg Ala Gly Asp Ala Val Ala 
        355                 360                 365             


Phe Pro His Pro Arg Pro Phe Leu Ala Ser Pro Pro Pro Ala Leu Gly 
    370                 375                 380                 


Arg Tyr Phe Ser Val Asp Gly Gly Ala Arg Gly Gly Pro Val Gly Pro 
385                 390                 395                 400 


Cys Pro Pro Ser Pro Pro Pro Arg Arg Pro Arg Glu Arg Ser Pro Gly 
                405                 410                 415     


Pro Val Asp Thr Arg Ser Pro Ala Ser Ser Gly Lys Ala Pro Pro Arg 
            420                 425                 430         


Gly Gly Leu Thr Gly Ala Thr Ser Pro Ala Trp Thr Arg Gly Gly Lys 
        435                 440                 445             


Gln Gly Glu Thr Gly 
    450             


<210>  6114
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  6114

Met Cys Thr Ser Gly Gln Ile Ile Gly Ser Leu Leu Val Leu Ser Val 
1               5                   10                  15      


Leu Glu Ile Gly Leu Gly Val Ser Ser Val Ala Val Gly Ala Val Ser 
            20                  25                  30          


Phe Ser Leu Ala Leu Arg Glu His Lys Pro Gln Leu Gly Asp Ser Ser 
        35                  40                  45              


Pro Phe Leu Leu Cys Gly Ile Cys Gly Ile Leu Cys Ala Lys Lys Lys 
    50                  55                  60                  


Ser Gly Leu Val Met Ile Leu Phe Ser Ala Cys Cys Ile Cys Gly Leu 
65                  70                  75                  80  


Ile Gly Gly Ile Leu Asn Phe Gln Phe Leu Arg Ala Val Thr Lys Lys 
                85                  90                  95      


Thr Ser Ser Leu Tyr Pro Leu His Leu Ala Ser Met Ser Leu Ala Cys 
            100                 105                 110         


Ile Gly Ile Gly Gly Cys Thr Leu Ser Ser Trp Leu Thr Cys Arg Leu 
        115                 120                 125             


Ala Ser Tyr Glu Gln Arg Arg Met Phe Ser Glu Arg Glu His Ser Leu 
    130                 135                 140                 


His His Ser His Glu Met Ala Glu Lys Glu Ile Thr Asp Asn Met Ser 
145                 150                 155                 160 


Asn Gly Gly Pro Gln Leu Ile Phe Asn Gly Arg Val 
                165                 170         


<210>  6115
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  6115

Met Ala Gly Leu Arg Asn Glu Ser Glu Gln Glu Pro Leu Leu Gly Asp 
1               5                   10                  15      


Thr Pro Gly Ser Arg Glu Trp Asp Ile Leu Glu Thr Glu Glu His Tyr 
            20                  25                  30          


Lys Ser Arg Trp Arg Ser Ile Arg Ile Leu Tyr Leu Thr Met Phe Leu 
        35                  40                  45              


Ser Ser Val Gly Phe Ser Val Val Met Met Ser Ile Trp Pro Tyr Leu 
    50                  55                  60                  


Gln Lys Ile Asp Pro Thr Ala Asp Thr Ser Phe Leu Gly Trp Val Ile 
65                  70                  75                  80  


Ala Ser Tyr Ser Leu Gly Gln Met Val Ala Ser Pro Ile Phe Gly Leu 
                85                  90                  95      


Trp Ser Asn Tyr Arg Pro Arg Lys Glu Pro Leu Ile Val Ser Ile Leu 
            100                 105                 110         


Ile Ser Val Ala Ala Asn Cys Leu Tyr Ala Tyr Leu His Ile Pro Ala 
        115                 120                 125             


Ser His Asn Lys Tyr Tyr Met Leu Val Ala Arg Gly Leu Leu Gly Ile 
    130                 135                 140                 


Gly Ala Gly Asn Val Ala Val Val Arg Ser Tyr Thr Ala Gly Ala Thr 
145                 150                 155                 160 


Ser Leu Gln Glu Arg Thr Ser Ser Met Ala Asn Ile Ser Met Cys Gln 
                165                 170                 175     


Ala Leu Gly Phe Ile Leu Gly Pro Val Phe Gln Thr Cys Phe Thr Phe 
            180                 185                 190         


Leu Gly Glu Lys Gly Val Thr Trp Asp Val Ile Lys Leu Gln Ile Asn 
        195                 200                 205             


Met Tyr Thr Thr Pro Val Leu Leu Ser Ala Phe Leu Gly Ile Leu Asn 
    210                 215                 220                 


Ile Ile Leu Ile Leu Ala Ile Leu Arg Glu His Arg Val Asp Asp Ser 
225                 230                 235                 240 


Gly Arg Gln Cys Lys Ser Ile Asn Phe Glu Glu Ala Ser Thr Asp Glu 
                245                 250                 255     


Ala Gln Val Pro Gln Gly Asn Ile Asp Gln Val Ala Val Val Ala Ile 
            260                 265                 270         


Asn Val Leu Phe Phe Val Thr Leu Phe Ile Phe Ala Leu Phe Glu Thr 
        275                 280                 285             


Ile Ile Thr Pro Leu Thr Met Asp Met Tyr Ala Trp Thr Gln Glu Gln 
    290                 295                 300                 


Ala Val Leu Tyr Asn Gly Ile Ile Leu Ala Ala Leu Gly Val Glu Ala 
305                 310                 315                 320 


Val Val Ile Phe Leu Gly Val Lys Leu Leu Ser Lys Lys Ile Gly Glu 
                325                 330                 335     


Arg Ala Ile Leu Leu Gly Gly Leu Ile Val Val Trp Val Gly Phe Phe 
            340                 345                 350         


Ile Leu Leu Pro Trp Gly Asn Gln Phe Pro Lys Ile Gln Trp Glu Asp 
        355                 360                 365             


Leu His Asn Asn Ser Ile Pro Asn Thr Thr Phe Gly Glu Ile Ile Ile 
    370                 375                 380                 


Gly Leu Trp Lys Ser Pro Met Glu Asp Asp Asn Glu Arg Pro Thr Gly 
385                 390                 395                 400 


Cys Ser Ile Glu Gln Ala Trp Cys Leu Tyr Thr Pro Val Ile His Leu 
                405                 410                 415     


Ala Gln Phe Leu Thr Ser Ala Val Leu Ile Gly Leu Gly Tyr Pro Val 
            420                 425                 430         


Cys Asn Leu Met Ser Tyr Thr Leu Tyr Ser Lys Ile Leu Gly Pro Lys 
        435                 440                 445             


Pro Gln Gly Val Tyr Met Gly Trp Leu Thr Ala Ser Gly Ser Gly Ala 
    450                 455                 460                 


Arg Ile Leu Gly Pro Met Phe Ile Ser Gln Val Tyr Ala His Trp Gly 
465                 470                 475                 480 


Pro Arg Trp Ala Phe Ser Leu Val Cys Gly Ile Ile Val Leu Thr Ile 
                485                 490                 495     


Thr Leu Leu Gly Val Val Tyr Lys Arg Leu Ile Ala Leu Ser Val Arg 
            500                 505                 510         


Tyr Gly Arg Ile Gln Glu 
        515             


<210>  6116
<211>  732
<212>  PRT
<213>  Homo sapiens

<400>  6116

Met Gly Gln Gly Trp Ala Thr Ala Gly Leu Pro Ser Leu Leu Phe Leu 
1               5                   10                  15      


Leu Leu Cys Tyr Gly His Pro Leu Leu Val Pro Ser Gln Glu Ala Ser 
            20                  25                  30          


Gln Gln Val Thr Val Thr His Gly Thr Ser Ser Gln Ala Thr Thr Ser 
        35                  40                  45              


Ser Gln Thr Thr Thr His Gln Ala Thr Ala His Gln Thr Ser Ala Gln 
    50                  55                  60                  


Ser Pro Asn Leu Val Thr Asp Glu Ala Glu Ala Ser Lys Phe Val Glu 
65                  70                  75                  80  


Glu Tyr Asp Arg Thr Ser Gln Val Val Trp Asn Glu Tyr Ala Glu Ala 
                85                  90                  95      


Asn Trp Asn Tyr Asn Thr Asn Ile Thr Thr Glu Thr Ser Lys Ile Leu 
            100                 105                 110         


Leu Gln Lys Asn Met Gln Ile Ala Asn His Thr Leu Lys Tyr Gly Thr 
        115                 120                 125             


Gln Ala Arg Lys Phe Asp Val Asn Gln Leu Gln Asn Thr Thr Ile Lys 
    130                 135                 140                 


Arg Ile Ile Lys Lys Val Gln Asp Leu Glu Arg Ala Ala Leu Pro Ala 
145                 150                 155                 160 


Gln Glu Leu Glu Glu Tyr Asn Lys Ile Leu Leu Asp Met Glu Thr Thr 
                165                 170                 175     


Tyr Ser Val Ala Thr Val Cys His Pro Asn Gly Ser Cys Leu Gln Leu 
            180                 185                 190         


Glu Pro Asp Leu Thr Asn Val Met Ala Thr Ser Arg Lys Tyr Glu Asp 
        195                 200                 205             


Leu Leu Trp Ala Trp Glu Gly Trp Arg Asp Lys Ala Gly Arg Ala Ile 
    210                 215                 220                 


Leu Gln Phe Tyr Pro Lys Tyr Val Glu Leu Ile Asn Gln Ala Ala Arg 
225                 230                 235                 240 


Leu Asn Gly Tyr Val Asp Ala Gly Asp Ser Trp Arg Ser Met Tyr Glu 
                245                 250                 255     


Thr Pro Ser Leu Glu Gln Asp Leu Glu Arg Leu Phe Gln Glu Leu Gln 
            260                 265                 270         


Pro Leu Tyr Leu Asn Leu His Ala Tyr Val Arg Arg Ala Leu His Arg 
        275                 280                 285             


His Tyr Gly Ala Gln His Ile Asn Leu Glu Gly Pro Ile Pro Ala His 
    290                 295                 300                 


Leu Leu Gly Asn Met Trp Ala Gln Thr Trp Ser Asn Ile Tyr Asp Leu 
305                 310                 315                 320 


Val Val Pro Phe Pro Ser Ala Pro Ser Met Asp Thr Thr Glu Ala Met 
                325                 330                 335     


Leu Lys Gln Gly Trp Thr Pro Arg Arg Met Phe Lys Glu Ala Asp Asp 
            340                 345                 350         


Phe Phe Thr Ser Leu Gly Leu Leu Pro Val Pro Pro Glu Phe Trp Asn 
        355                 360                 365             


Lys Ser Met Leu Glu Lys Pro Thr Asp Gly Arg Glu Val Val Cys His 
    370                 375                 380                 


Ala Ser Ala Trp Asp Phe Tyr Asn Gly Lys Asp Phe Arg Ile Lys Gln 
385                 390                 395                 400 


Cys Thr Thr Val Asn Leu Glu Asp Leu Val Val Ala His His Glu Met 
                405                 410                 415     


Gly His Ile Gln Tyr Phe Met Gln Tyr Lys Asp Leu Pro Val Ala Leu 
            420                 425                 430         


Arg Glu Gly Ala Asn Pro Gly Phe His Glu Ala Ile Gly Asp Val Leu 
        435                 440                 445             


Ala Leu Ser Val Ser Thr Pro Lys His Leu His Ser Leu Asn Leu Leu 
    450                 455                 460                 


Ser Ser Glu Gly Gly Ser Asp Glu His Asp Ile Asn Phe Leu Met Lys 
465                 470                 475                 480 


Met Ala Leu Asp Lys Ile Ala Phe Ile Pro Phe Ser Tyr Leu Val Asp 
                485                 490                 495     


Gln Trp Arg Trp Arg Val Phe Asp Gly Ser Ile Thr Lys Glu Asn Tyr 
            500                 505                 510         


Asn Gln Glu Trp Trp Ser Leu Arg Leu Lys Tyr Gln Gly Leu Cys Pro 
        515                 520                 525             


Pro Val Pro Arg Thr Gln Gly Asp Phe Asp Pro Gly Ala Lys Phe His 
    530                 535                 540                 


Ile Pro Ser Ser Val Pro Tyr Ile Arg Tyr Phe Val Ser Phe Ile Ile 
545                 550                 555                 560 


Gln Phe Gln Phe His Glu Ala Leu Cys Gln Ala Ala Gly His Thr Gly 
                565                 570                 575     


Pro Leu His Lys Cys Asp Ile Tyr Gln Ser Lys Glu Ala Gly Gln Arg 
            580                 585                 590         


Leu Ala Thr Ala Met Lys Leu Gly Phe Ser Arg Pro Trp Pro Glu Ala 
        595                 600                 605             


Met Gln Leu Ile Thr Gly Gln Pro Asn Met Ser Ala Ser Ala Met Leu 
    610                 615                 620                 


Ser Tyr Phe Lys Pro Leu Leu Asp Trp Leu Arg Thr Glu Asn Glu Leu 
625                 630                 635                 640 


His Gly Glu Lys Leu Gly Trp Pro Gln Tyr Asn Trp Thr Pro Asn Ser 
                645                 650                 655     


Ala Arg Ser Glu Gly Pro Leu Pro Asp Ser Gly Arg Val Ser Phe Leu 
            660                 665                 670         


Gly Leu Asp Leu Asp Ala Gln Gln Ala Arg Val Gly Gln Trp Leu Leu 
        675                 680                 685             


Leu Phe Leu Gly Ile Ala Leu Leu Val Ala Thr Leu Gly Leu Ser Gln 
    690                 695                 700                 


Arg Leu Phe Ser Ile Arg His Arg Ser Leu His Arg His Ser His Gly 
705                 710                 715                 720 


Pro Gln Phe Gly Ser Glu Val Glu Leu Arg His Ser 
                725                 730         


<210>  6117
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  6117

Met Pro Val Met Pro Ile Pro Arg Arg Val Arg Ser Phe His Gly Pro 
1               5                   10                  15      


His Thr Thr Cys Leu His Ala Ala Cys Gly Pro Val Arg Ala Ser His 
            20                  25                  30          


Leu Ala Arg Thr Lys Tyr Asn Asn Phe Asp Val Tyr Ile Lys Thr Arg 
        35                  40                  45              


Trp Leu Tyr Gly Phe Ile Arg Phe Leu Leu Tyr Phe Ser Cys Ser Leu 
    50                  55                  60                  


Phe Thr Ala Ala Leu Trp Gly Ala Leu Ala Ala Leu Phe Cys Leu Gln 
65                  70                  75                  80  


Tyr Leu Gly Val Arg Val Leu Leu Arg Phe Gln Arg Lys Leu Ser Val 
                85                  90                  95      


Leu Leu Leu Leu Leu Gly Arg Arg Arg Val Asp Phe Arg Leu Val Asn 
            100                 105                 110         


Glu Leu Leu Val Tyr Gly Ile His Val Thr Met Leu Leu Val Gly Gly 
        115                 120                 125             


Leu Gly Trp Cys Phe Met Val Phe Val Asp Met 
    130                 135                 


<210>  6118
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  6118

Met Pro Ser Ala Phe Ser Val Ser Ser Phe Pro Val Ser Ile Pro Ala 
1               5                   10                  15      


Val Leu Thr Gln Thr Asp Trp Thr Glu Pro Trp Leu Met Gly Leu Ala 
            20                  25                  30          


Thr Phe His Ala Leu Cys Val Leu Leu Thr Cys Leu Ser Ser Arg Ser 
        35                  40                  45              


Tyr Arg Leu Gln Ile Gly His Phe Leu Cys Leu Val Ile Leu Val Tyr 
    50                  55                  60                  


Cys Ala Glu Tyr Ile Asn Glu Ala Ala Ala Met Asn Trp Arg Leu Phe 
65                  70                  75                  80  


Ser Lys Tyr Gln Tyr Phe Asp Ser Arg Gly Met Phe Ile Ser Ile Val 
                85                  90                  95      


Phe Ser Ala Pro Leu Leu Val Asn Ala Met Ile Ile Val Val Met Trp 
            100                 105                 110         


Val Trp Lys Thr Leu Asn Val Met Thr Asp Leu Lys Asn Ala Gln Glu 
        115                 120                 125             


Arg Arg Lys Glu Lys Lys Arg Arg Arg Lys Glu Asp 
    130                 135                 140 


<210>  6119
<211>  672
<212>  PRT
<213>  Homo sapiens

<400>  6119

Met Gln Lys Ala Ser Val Leu Leu Phe Leu Ala Trp Val Cys Phe Leu 
1               5                   10                  15      


Phe Tyr Ala Gly Ile Ala Leu Phe Thr Ser Gly Phe Leu Leu Thr Arg 
            20                  25                  30          


Leu Glu Leu Thr Asn His Ser Ser Cys Gln Glu Pro Pro Gly Pro Gly 
        35                  40                  45              


Ser Leu Pro Trp Gly Ser Gln Gly Lys Pro Gly Ala Cys Trp Met Ala 
    50                  55                  60                  


Ser Arg Phe Ser Arg Val Val Leu Val Leu Ile Asp Ala Leu Arg Phe 
65                  70                  75                  80  


Asp Phe Ala Gln Pro Gln His Ser His Val Pro Arg Glu Pro Pro Val 
                85                  90                  95      


Ser Leu Pro Phe Leu Gly Lys Leu Ser Ser Leu Gln Arg Ile Leu Glu 
            100                 105                 110         


Ile Gln Pro His His Ala Arg Leu Tyr Arg Ser Gln Val Asp Pro Pro 
        115                 120                 125             


Thr Thr Thr Met Gln Arg Leu Lys Ala Leu Thr Thr Gly Ser Leu Pro 
    130                 135                 140                 


Thr Phe Ile Asp Ala Gly Ser Asn Phe Ala Ser His Ala Ile Val Glu 
145                 150                 155                 160 


Asp Asn Leu Ile Lys Gln Leu Thr Ser Ala Gly Arg Arg Val Val Phe 
                165                 170                 175     


Met Gly Asp Asp Thr Trp Lys Asp Leu Phe Pro Gly Ala Phe Ser Lys 
            180                 185                 190         


Ala Phe Phe Phe Pro Ser Phe Asn Val Arg Asp Leu Asp Thr Val Asp 
        195                 200                 205             


Asn Gly Ile Leu Glu His Leu Tyr Pro Thr Met Asp Ser Gly Glu Trp 
    210                 215                 220                 


Asp Val Leu Ile Ala His Phe Leu Gly Val Asp His Cys Gly His Lys 
225                 230                 235                 240 


His Gly Pro His His Pro Glu Met Ala Lys Lys Leu Ser Gln Met Asp 
                245                 250                 255     


Gln Val Ile Gln Gly Leu Val Glu Arg Leu Glu Asn Asp Thr Leu Leu 
            260                 265                 270         


Val Val Ala Gly Asp His Gly Met Thr Thr Asn Gly Asp His Gly Gly 
        275                 280                 285             


Asp Ser Glu Leu Glu Val Ser Ala Ala Leu Phe Leu Tyr Ser Pro Thr 
    290                 295                 300                 


Ala Val Phe Pro Ser Thr Pro Pro Glu Glu Pro Glu Val Ile Pro Gln 
305                 310                 315                 320 


Val Ser Leu Val Pro Thr Leu Ala Leu Leu Leu Gly Leu Pro Ile Pro 
                325                 330                 335     


Phe Gly Asn Ile Gly Glu Val Met Ala Glu Leu Phe Ser Gly Gly Glu 
            340                 345                 350         


Asp Ser Gln Pro His Ser Ser Ala Leu Ala Gln Ala Ser Ala Leu His 
        355                 360                 365             


Leu Asn Ala Gln Gln Val Ser Arg Phe Leu His Thr Tyr Ser Ala Ala 
    370                 375                 380                 


Thr Gln Asp Leu Gln Ala Lys Glu Leu His Gln Leu Gln Asn Leu Phe 
385                 390                 395                 400 


Ser Lys Ala Ser Ala Asp Tyr Gln Trp Leu Leu Gln Ser Pro Lys Gly 
                405                 410                 415     


Ala Glu Ala Thr Leu Pro Thr Val Ile Ala Glu Leu Gln Gln Phe Leu 
            420                 425                 430         


Arg Gly Ala Arg Ala Met Cys Ile Glu Ser Trp Ala Arg Phe Ser Leu 
        435                 440                 445             


Ser Phe Leu Leu Leu His Leu Leu Ala Ala Gly Ile Pro Val Thr Thr 
    450                 455                 460                 


Pro Gly Pro Phe Thr Val Pro Trp Gln Ala Val Ser Ala Trp Ala Leu 
465                 470                 475                 480 


Met Ala Thr Gln Thr Phe Tyr Ser Thr Gly His Gln Pro Val Phe Pro 
                485                 490                 495     


Ala Ile His Trp His Ala Ala Phe Val Gly Phe Pro Glu Gly His Gly 
            500                 505                 510         


Ser Cys Thr Trp Leu Pro Ala Leu Leu Val Gly Ala Asn Thr Phe Ala 
        515                 520                 525             


Ser His Leu Leu Phe Ala Val Gly Cys Pro Leu Leu Leu Leu Trp Pro 
    530                 535                 540                 


Phe Leu Cys Glu Ser Gln Gly Leu Arg Lys Arg Gln Gln Pro Pro Gly 
545                 550                 555                 560 


Asn Glu Ala Asp Ala Arg Val Arg Pro Glu Glu Glu Glu Glu Pro Leu 
                565                 570                 575     


Met Glu Met Arg Leu Arg Asp Ala Pro Gln His Phe Tyr Ala Ala Leu 
            580                 585                 590         


Leu Gln Leu Gly Leu Lys Tyr Leu Phe Ile Leu Gly Ile Gln Ile Leu 
        595                 600                 605             


Ala Cys Ala Leu Ala Ala Ser Ile Leu Arg Arg His Leu Met Val Trp 
    610                 615                 620                 


Lys Val Phe Ala Pro Lys Phe Ile Phe Glu Ala Val Gly Phe Ile Val 
625                 630                 635                 640 


Ser Ser Val Gly Leu Leu Leu Gly Ile Ala Leu Val Met Arg Val Asp 
                645                 650                 655     


Gly Ala Val Ser Ser Trp Phe Arg Gln Leu Phe Leu Ala Gln Gln Arg 
            660                 665                 670         


<210>  6120
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  6120

Met Thr Ser Gln Pro Val Pro Asn Glu Thr Ile Ile Val Leu Pro Ser 
1               5                   10                  15      


Asn Val Ile Asn Phe Ser Gln Ala Glu Lys Pro Glu Pro Thr Asn Gln 
            20                  25                  30          


Gly Gln Asp Ser Leu Lys Lys His Leu His Ala Glu Ile Lys Val Ile 
        35                  40                  45              


Gly Thr Ile Gln Ile Leu Cys Gly Met Met Val Leu Ser Leu Gly Ile 
    50                  55                  60                  


Ile Leu Ala Ser Ala Ser Phe Ser Pro Asn Phe Thr Gln Val Thr Ser 
65                  70                  75                  80  


Thr Leu Leu Asn Ser Ala Tyr Pro Phe Ile Gly Pro Phe Phe Phe Ile 
                85                  90                  95      


Ile Ser Gly Ser Leu Ser Ile Ala Thr Glu Lys Arg Leu Thr Lys Leu 
            100                 105                 110         


Leu Val His Ser Ser Leu Val Gly Ser Ile Leu Ser Ala Leu Ser Ala 
        115                 120                 125             


Leu Val Gly Phe Ile Ile Leu Ser Val Lys Gln Ala Thr Leu Asn Pro 
    130                 135                 140                 


Ala Ser Leu Gln Trp Asn Ser Leu Ser Asp Ala Asp Leu His Ser Ala 
145                 150                 155                 160 


Gly Ile Leu Pro Ser Cys Ala His Cys Cys Ala Ala Val Glu Thr Gly 
                165                 170                 175     


Leu Leu 
        


<210>  6121
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  6121

Met Thr Ser Gln Pro Val Pro Asn Glu Thr Ile Ile Val Leu Pro Ser 
1               5                   10                  15      


Asn Val Ile Asn Phe Ser Gln Ala Glu Lys Pro Glu Pro Thr Asn Gln 
            20                  25                  30          


Gly Gln Asp Ser Leu Lys Lys His Leu His Ala Glu Ile Lys Val Ile 
        35                  40                  45              


Gly Thr Ile Gln Ile Leu Cys Gly Met Met Val Leu Ser Leu Gly Ile 
    50                  55                  60                  


Ile Leu Ala Ser Ala Ser Phe Ser Pro Asn Phe Thr Gln Val Thr Ser 
65                  70                  75                  80  


Thr Leu Leu Asn Ser Ala Tyr Pro Phe Ile Gly Pro Phe Phe Phe Ile 
                85                  90                  95      


Ile Ser Gly Ser Leu Ser Ile Ala Thr Glu Lys Arg Leu Thr Lys Leu 
            100                 105                 110         


Leu Val His Ser Ser Leu Val Gly Ser Ile Leu Ser Ala Leu Ser Ala 
        115                 120                 125             


Leu Val Gly Phe Ile Ile Leu Ser Val Lys Gln Ala Thr Leu Asn Pro 
    130                 135                 140                 


Ala Ser Leu Gln Cys Glu Leu Asp Lys Asn Asn Ile Pro Thr Arg Ser 
145                 150                 155                 160 


Tyr Val Ser Tyr Phe Tyr His Asp Ser Leu Tyr Thr Thr Asp Cys Tyr 
                165                 170                 175     


Thr Ala Lys Ala Ser Leu Ala Gly Thr Leu Ser Leu Met Leu Ile Cys 
            180                 185                 190         


Thr Leu Leu Glu Phe Cys Leu Ala Val Leu Thr Ala Val Leu Arg Trp 
        195                 200                 205             


Lys Gln Ala Tyr Ser Asp Phe Pro Gly Ser Val Leu Phe Leu Pro His 
    210                 215                 220                 


Ser Tyr Ile Gly Asn Ser Gly Met Ser Ser Lys Met Thr His Asp Cys 
225                 230                 235                 240 


Gly Tyr Glu Glu Leu Leu Thr Ser 
                245             


<210>  6122
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  6122

Met Gly Ser Cys Ser Gly Arg Cys Ala Leu Val Val Leu Cys Ala Phe 
1               5                   10                  15      


Gln Leu Val Ala Ala Leu Glu Arg Gln Val Phe Asp Phe Leu Gly Tyr 
            20                  25                  30          


Gln Trp Ala Pro Ile Leu Ala Asn Phe Val His Ile Ile Ile Val Ile 
        35                  40                  45              


Leu Gly Leu Phe Gly Thr Ile Gln Tyr Arg Leu Arg Tyr Val Met Val 
    50                  55                  60                  


Tyr Thr Leu Trp Ala Ala Val Trp Val Thr Trp Asn Val Phe Ile Ile 
65                  70                  75                  80  


Cys Phe Tyr Leu Glu Val Gly Gly Leu Leu Lys Asp Ser Glu Leu Leu 
                85                  90                  95      


Thr Phe Ser Leu Ser Arg His Arg Ser Trp Trp Arg Glu Arg Trp Pro 
            100                 105                 110         


Gly Cys Leu His Glu Glu Val Pro Ala Val Gly Leu Gly Ala Pro His 
        115                 120                 125             


Gly Gln Ala Leu Val Ser Gly Ala Gly Cys Ala Leu Glu Pro Ser Tyr 
    130                 135                 140                 


Val Glu Ala Leu His Ser Cys Leu Gln Ile Leu Ile Ala Leu Leu Gly 
145                 150                 155                 160 


Phe Val Cys Gly Cys Gln Val Val Ser Val Phe Thr Glu Glu Glu Asp 
                165                 170                 175     


Ser Phe Asp Phe Ile Gly Gly Phe Asp Pro Phe Pro Leu Tyr His Val 
            180                 185                 190         


Asn Glu Lys Pro Ser Ser Leu Leu Ser Lys Gln Val Tyr Leu Pro Ala 
        195                 200                 205             


<210>  6123
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  6123

Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro 
1               5                   10                  15      


Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg 
            20                  25                  30          


Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu 
        35                  40                  45              


Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile 
    50                  55                  60                  


Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile 
65                  70                  75                  80  


Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile 
                85                  90                  95      


Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu 
            100                 105                 110         


Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile 
        115                 120                 125             


Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser 
    130                 135                 140                 


His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro 
145                 150                 155                 160 


Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn 
                165                 170                 175     


Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly 
            180                 185                 190         


Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile 
        195                 200                 205             


Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys 
    210                 215                 220                 


Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile 
225                 230                 235                 240 


Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro 
                245                 250                 255     


Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu 
            260                 265                 270         


Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser 
        275                 280                 285             


Ser Pro Ile Glu Asn Asp Ser Ser Pro 
    290                 295         


<210>  6124
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  6124

Met His Gly His Ser Arg Asn Gly Gln Ala His Val Pro Arg Arg Lys 
1               5                   10                  15      


Arg Arg Asn Arg Phe Val Lys Lys Asn Gly Gln Cys Asn Val Tyr Phe 
            20                  25                  30          


Ala Asn Leu Ser Asn Lys Ser Gln Arg Tyr Met Ala Asp Ile Phe Thr 
        35                  40                  45              


Thr Cys Val Asp Thr Arg Trp Arg Tyr Met Leu Met Ile Phe Ser Ala 
    50                  55                  60                  


Ala Phe Leu Val Ser Trp Leu Phe Phe Gly Leu Leu Phe Trp Cys Ile 
65                  70                  75                  80  


Ala Phe Phe His Gly Asp Leu Glu Ala Ser Pro Gly Val Pro Ala Ala 
                85                  90                  95      


Gly Gly Pro Ala Ala Gly Gly Gly Gly Ala Ala Pro Val Ala Pro Lys 
            100                 105                 110         


Pro Cys Ile Met His Val Asn Gly Phe Leu Gly Ala Phe Leu Phe Ser 
        115                 120                 125             


Val Glu Thr Gln Thr Thr Ile Gly Tyr Gly Phe Arg Cys Val Thr Glu 
    130                 135                 140                 


Glu Cys Pro Leu Ala Val Ile Ala Val Val Val Gln Ser Ile Val Gly 
145                 150                 155                 160 


Cys Val Ile Asp Ser Phe Met Ile Gly Thr Ile Met Ala Lys Met Ala 
                165                 170                 175     


Arg Pro Lys Lys Arg Ala Gln Thr Leu Leu Phe Ser His His Ala Val 
            180                 185                 190         


Ile Ser Val Arg Asp Gly Lys Leu Cys Leu Met Trp Arg Val Gly Asn 
        195                 200                 205             


Leu Arg Lys Ser His Ile Val Glu Ala His Val Arg Ala Gln Leu Ile 
    210                 215                 220                 


Lys Pro Tyr Met Thr Gln Glu Gly Glu Tyr Leu Pro Leu Asp Gln Arg 
225                 230                 235                 240 


Asp Leu Asn Val Gly Tyr Asp Ile Gly Leu Asp Arg Ile Phe Leu Val 
                245                 250                 255     


Ser Pro Ile Ile Ile Val His Glu Ile Asp Glu Asp Ser Pro Leu Tyr 
            260                 265                 270         


Gly Met Gly Lys Glu Glu Leu Glu Ser Glu Asp Phe Glu Ile Val Val 
        275                 280                 285             


Ile Leu Glu Gly Met Val Glu Ala Thr Ala Met Thr Thr Gln Ala Arg 
    290                 295                 300                 


Ser Ser Tyr Leu Ala Ser Glu Ile Leu Trp Gly His Arg Phe Glu Pro 
305                 310                 315                 320 


Val Val Phe Glu Glu Lys Ser His Tyr Lys Val Asp Tyr Ser Arg Phe 
                325                 330                 335     


His Lys Thr Tyr Glu Val Ala Gly Thr Pro Cys Cys Ser Ala Arg Glu 
            340                 345                 350         


Leu Gln Glu Ser Lys Ile Thr Val Leu Pro Ala Pro Pro Pro Pro Pro 
        355                 360                 365             


Ser Ala Phe Cys Tyr Glu Asn Glu Leu Ala Leu Met Ser Gln Glu Glu 
    370                 375                 380                 


Glu Glu Met Glu Glu Glu Ala Ala Ala Ala Ala Ala Val Ala Ala Gly 
385                 390                 395                 400 


Leu Gly Leu Glu Ala Gly Ser Lys Glu Glu Ala Gly Ile Ile Arg Met 
                405                 410                 415     


Leu Glu Phe Gly Ser His Leu Asp Leu Glu Arg Met Gln Ala Ser Leu 
            420                 425                 430         


Pro Leu Asp Asn Ile Ser Tyr Arg Arg Glu Ser Ala Ile 
        435                 440                 445 


<210>  6125
<211>  1030
<212>  PRT
<213>  Homo sapiens

<400>  6125

Met Gly Ala Ala Arg Gly Ser Pro Ala Arg Pro Arg Arg Leu Pro Leu 
1               5                   10                  15      


Leu Ser Val Leu Leu Leu Pro Leu Leu Gly Gly Thr Gln Thr Ala Ile 
            20                  25                  30          


Val Phe Ile Lys Gln Pro Ser Ser Gln Asp Ala Leu Gln Gly Arg Arg 
        35                  40                  45              


Ala Leu Leu Arg Cys Glu Val Glu Ala Pro Gly Pro Val His Val Tyr 
    50                  55                  60                  


Trp Leu Leu Asp Gly Ala Pro Val Gln Asp Thr Glu Arg Arg Phe Ala 
65                  70                  75                  80  


Gln Gly Ser Ser Leu Ser Phe Ala Ala Val Asp Arg Leu Gln Asp Ser 
                85                  90                  95      


Gly Thr Phe Gln Cys Val Ala Arg Asp Asp Val Thr Gly Glu Glu Ala 
            100                 105                 110         


Arg Ser Ala Asn Ala Ser Phe Asn Ile Lys Trp Ile Glu Ala Gly Pro 
        115                 120                 125             


Val Val Leu Lys His Pro Ala Ser Glu Ala Glu Ile Gln Pro Gln Thr 
    130                 135                 140                 


Gln Val Thr Leu Arg Cys His Ile Asp Gly His Pro Arg Pro Thr Tyr 
145                 150                 155                 160 


Gln Trp Phe Arg Asp Gly Thr Pro Leu Ser Asp Gly Gln Ser Asn His 
                165                 170                 175     


Thr Val Ser Ser Lys Glu Arg Asn Leu Thr Leu Arg Pro Ala Gly Pro 
            180                 185                 190         


Glu His Ser Gly Leu Tyr Ser Cys Cys Ala His Ser Ala Phe Gly Gln 
        195                 200                 205             


Ala Cys Ser Ser Gln Asn Phe Thr Leu Ser Ile Ala Asp Glu Ser Phe 
    210                 215                 220                 


Ala Arg Val Val Leu Ala Pro Gln Asp Val Val Val Ala Arg Tyr Glu 
225                 230                 235                 240 


Glu Ala Met Phe His Cys Gln Phe Ser Ala Gln Pro Pro Pro Ser Leu 
                245                 250                 255     


Gln Trp Leu Phe Glu Asp Glu Thr Pro Ile Thr Asn Arg Ser Arg Pro 
            260                 265                 270         


Pro His Leu Arg Arg Ala Thr Val Phe Ala Asn Gly Ser Leu Leu Leu 
        275                 280                 285             


Thr Gln Val Arg Pro Arg Asn Ala Gly Ile Tyr Arg Cys Ile Gly Gln 
    290                 295                 300                 


Gly Gln Arg Gly Pro Pro Ile Ile Leu Glu Ala Thr Leu His Leu Ala 
305                 310                 315                 320 


Glu Ile Glu Asp Met Pro Leu Phe Glu Pro Arg Val Phe Thr Ala Gly 
                325                 330                 335     


Ser Glu Glu Arg Val Thr Cys Leu Pro Pro Lys Gly Leu Pro Glu Pro 
            340                 345                 350         


Ser Val Trp Trp Glu His Ala Gly Val Arg Leu Pro Thr His Gly Arg 
        355                 360                 365             


Val Tyr Gln Lys Gly His Glu Leu Val Leu Ala Asn Ile Ala Glu Ser 
    370                 375                 380                 


Asp Ala Gly Val Tyr Thr Cys His Ala Ala Asn Leu Ala Gly Gln Arg 
385                 390                 395                 400 


Arg Gln Asp Val Asn Ile Thr Val Ala Thr Val Pro Ser Trp Leu Lys 
                405                 410                 415     


Lys Pro Gln Asp Ser Gln Leu Glu Glu Gly Lys Pro Gly Tyr Leu Asp 
            420                 425                 430         


Cys Leu Thr Gln Ala Thr Pro Lys Pro Thr Val Val Trp Tyr Arg Asn 
        435                 440                 445             


Gln Met Leu Ile Ser Glu Asp Ser Arg Phe Glu Val Phe Lys Asn Gly 
    450                 455                 460                 


Thr Leu Arg Ile Asn Ser Val Glu Val Tyr Asp Gly Thr Trp Tyr Arg 
465                 470                 475                 480 


Cys Met Ser Ser Thr Pro Ala Gly Ser Ile Glu Ala Gln Ala Arg Val 
                485                 490                 495     


Gln Val Leu Asp Gly Ser Ser Leu Pro Glu Trp Val Thr Asp Asn Ala 
            500                 505                 510         


Gly Thr Leu His Phe Ala Arg Val Thr Arg Asp Asp Ala Gly Asn Tyr 
        515                 520                 525             


Thr Cys Ile Ala Ser Asn Gly Pro Gln Gly Gln Ile Arg Ala His Val 
    530                 535                 540                 


Gln Leu Thr Val Ala Val Phe Ile Thr Phe Lys Val Glu Pro Glu Arg 
545                 550                 555                 560 


Thr Thr Val Tyr Gln Gly His Thr Ala Leu Leu Gln Cys Glu Ala Gln 
                565                 570                 575     


Gly Asp Pro Lys Pro Leu Ile Gln Trp Lys Gly Lys Asp Arg Ile Leu 
            580                 585                 590         


Asp Pro Thr Lys Leu Gly Pro Arg Met His Ile Phe Gln Asn Gly Ser 
        595                 600                 605             


Leu Val Ile His Asp Val Ala Pro Glu Asp Ser Gly Arg Tyr Thr Cys 
    610                 615                 620                 


Ile Ala Gly Asn Ser Cys Asn Ile Lys His Thr Glu Ala Pro Leu Tyr 
625                 630                 635                 640 


Val Val Asp Lys Pro Val Pro Glu Glu Ser Glu Gly Pro Gly Ser Pro 
                645                 650                 655     


Pro Pro Tyr Lys Met Ile Gln Thr Ile Gly Leu Ser Val Gly Ala Ala 
            660                 665                 670         


Val Ala Tyr Ile Ile Ala Val Leu Gly Leu Met Phe Tyr Cys Lys Lys 
        675                 680                 685             


Arg Cys Lys Ala Lys Arg Leu Gln Lys Gln Pro Glu Gly Glu Glu Pro 
    690                 695                 700                 


Glu Met Glu Cys Leu Asn Gly Gly Pro Leu Gln Asn Gly Gln Pro Ser 
705                 710                 715                 720 


Ala Glu Ile Gln Glu Glu Val Ala Leu Thr Ser Leu Gly Ser Gly Pro 
                725                 730                 735     


Ala Ala Thr Asn Lys Arg His Ser Thr Ser Asp Lys Met His Phe Pro 
            740                 745                 750         


Arg Ser Ser Leu Gln Pro Ile Thr Thr Leu Gly Lys Ser Glu Phe Gly 
        755                 760                 765             


Glu Val Phe Leu Ala Lys Ala Gln Gly Leu Glu Glu Gly Val Ala Glu 
    770                 775                 780                 


Thr Leu Val Leu Val Lys Ser Leu Gln Ser Lys Asp Glu Gln Gln Gln 
785                 790                 795                 800 


Leu Asp Phe Arg Arg Glu Leu Glu Met Phe Gly Lys Leu Asn His Ala 
                805                 810                 815     


Asn Val Val Arg Leu Leu Gly Leu Cys Arg Glu Ala Glu Pro His Tyr 
            820                 825                 830         


Met Val Leu Glu Tyr Val Asp Leu Gly Asp Leu Lys Gln Phe Leu Arg 
        835                 840                 845             


Ile Ser Lys Ser Lys Asp Glu Lys Leu Lys Ser Gln Pro Leu Ser Thr 
    850                 855                 860                 


Lys Gln Lys Val Ala Leu Cys Thr Gln Val Ala Leu Gly Met Glu His 
865                 870                 875                 880 


Leu Ser Asn Asn Arg Phe Val His Lys Asp Leu Ala Ala Arg Asn Cys 
                885                 890                 895     


Leu Val Ser Ala Gln Arg Gln Val Lys Val Ser Ala Leu Gly Leu Ser 
            900                 905                 910         


Lys Asp Val Tyr Asn Ser Glu Tyr Tyr His Phe Arg Gln Ala Trp Val 
        915                 920                 925             


Pro Leu Arg Trp Met Ser Pro Glu Ala Ile Leu Glu Gly Asp Phe Ser 
    930                 935                 940                 


Thr Lys Ser Asp Val Trp Ala Phe Gly Val Leu Met Trp Glu Val Phe 
945                 950                 955                 960 


Thr His Gly Glu Met Pro His Gly Gly Gln Ala Asp Asp Glu Val Leu 
                965                 970                 975     


Ala Asp Leu Gln Ala Gly Lys Ala Arg Leu Pro Gln Pro Glu Gly Cys 
            980                 985                 990         


Pro Ser Lys Leu Tyr Arg Leu Met  Gln Arg Cys Trp Ala  Leu Ser Pro 
        995                 1000                 1005             


Lys Asp  Arg Pro Ser Phe Ser  Glu Ile Ala Ser Ala  Leu Gly Asp 
    1010                 1015                 1020             


Ser Thr  Val Asp Ser Lys Pro  
    1025                 1030 


<210>  6126
<211>  940
<212>  PRT
<213>  Homo sapiens

<400>  6126

Met Gly Ala Ala Arg Gly Ser Pro Ala Arg Pro Arg Arg Leu Pro Leu 
1               5                   10                  15      


Leu Ser Val Leu Leu Leu Pro Leu Leu Gly Gly Thr Gln Thr Ala Ile 
            20                  25                  30          


Val Phe Ile Lys Gln Pro Ser Ser Gln Asp Ala Leu Gln Gly Arg Arg 
        35                  40                  45              


Ala Leu Leu Arg Cys Glu Val Glu Ala Pro Gly Pro Val His Val Tyr 
    50                  55                  60                  


Trp Leu Leu Asp Gly Ala Pro Val Gln Asp Thr Glu Arg Arg Phe Ala 
65                  70                  75                  80  


Gln Gly Ser Ser Leu Ser Phe Ala Ala Val Asp Arg Leu Gln Asp Ser 
                85                  90                  95      


Gly Thr Phe Gln Cys Val Ala Arg Asp Asp Val Thr Gly Glu Glu Ala 
            100                 105                 110         


Arg Ser Ala Asn Ala Ser Phe Asn Ile Lys Trp Ile Glu Ala Gly Pro 
        115                 120                 125             


Val Val Leu Lys His Pro Ala Ser Glu Ala Glu Ile Gln Pro Gln Thr 
    130                 135                 140                 


Gln Val Thr Leu Arg Cys His Ile Asp Gly His Pro Arg Pro Thr Tyr 
145                 150                 155                 160 


Gln Trp Phe Arg Asp Gly Thr Pro Leu Ser Asp Gly Gln Ser Asn His 
                165                 170                 175     


Thr Val Ser Ser Lys Glu Arg Asn Leu Thr Leu Arg Pro Ala Gly Pro 
            180                 185                 190         


Glu His Ser Gly Leu Tyr Ser Cys Cys Ala His Ser Ala Phe Gly Gln 
        195                 200                 205             


Ala Cys Ser Ser Gln Asn Phe Thr Leu Ser Ile Ala Asp Glu Ser Phe 
    210                 215                 220                 


Ala Arg Val Val Leu Ala Pro Gln Asp Val Val Val Ala Arg Tyr Glu 
225                 230                 235                 240 


Glu Ala Met Phe His Cys Gln Phe Ser Ala Gln Pro Pro Pro Ser Leu 
                245                 250                 255     


Gln Trp Leu Phe Glu Asp Glu Thr Pro Ile Thr Asn Arg Ser Arg Pro 
            260                 265                 270         


Pro His Leu Arg Arg Ala Thr Val Phe Ala Asn Gly Ser Leu Leu Leu 
        275                 280                 285             


Thr Gln Val Arg Pro Arg Asn Ala Gly Ile Tyr Arg Cys Ile Gly Gln 
    290                 295                 300                 


Gly Gln Arg Gly Pro Pro Ile Ile Leu Glu Ala Thr Leu His Leu Ala 
305                 310                 315                 320 


Glu Ile Glu Asp Met Pro Leu Phe Glu Pro Arg Val Phe Thr Ala Gly 
                325                 330                 335     


Ser Glu Glu Arg Val Thr Cys Leu Pro Pro Lys Gly Leu Pro Glu Pro 
            340                 345                 350         


Ser Val Trp Trp Glu His Ala Gly Val Arg Leu Pro Thr His Gly Arg 
        355                 360                 365             


Val Tyr Gln Lys Gly His Glu Leu Val Leu Ala Asn Ile Ala Glu Ser 
    370                 375                 380                 


Asp Ala Gly Val Tyr Thr Cys His Ala Ala Asn Leu Ala Gly Gln Arg 
385                 390                 395                 400 


Arg Gln Asp Val Asn Ile Thr Val Ala Asn Gly Ser Ser Leu Pro Glu 
                405                 410                 415     


Trp Val Thr Asp Asn Ala Gly Thr Leu His Phe Ala Arg Val Thr Arg 
            420                 425                 430         


Asp Asp Ala Gly Asn Tyr Thr Cys Ile Ala Ser Asn Gly Pro Gln Gly 
        435                 440                 445             


Gln Ile Arg Ala His Val Gln Leu Thr Val Ala Val Phe Ile Thr Phe 
    450                 455                 460                 


Lys Val Glu Pro Glu Arg Thr Thr Val Tyr Gln Gly His Thr Ala Leu 
465                 470                 475                 480 


Leu Gln Cys Glu Ala Gln Gly Asp Pro Lys Pro Leu Ile Gln Trp Lys 
                485                 490                 495     


Gly Lys Asp Arg Ile Leu Asp Pro Thr Lys Leu Gly Pro Arg Met His 
            500                 505                 510         


Ile Phe Gln Asn Gly Ser Leu Val Ile His Asp Val Ala Pro Glu Asp 
        515                 520                 525             


Ser Gly Arg Tyr Thr Cys Ile Ala Gly Asn Ser Cys Asn Ile Lys His 
    530                 535                 540                 


Thr Glu Ala Pro Leu Tyr Val Val Asp Lys Pro Val Pro Glu Glu Ser 
545                 550                 555                 560 


Glu Gly Pro Gly Ser Pro Pro Pro Tyr Lys Met Ile Gln Thr Ile Gly 
                565                 570                 575     


Leu Ser Val Gly Ala Ala Val Ala Tyr Ile Ile Ala Val Leu Gly Leu 
            580                 585                 590         


Met Phe Tyr Cys Lys Lys Arg Cys Lys Ala Lys Arg Leu Gln Lys Gln 
        595                 600                 605             


Pro Glu Gly Glu Glu Pro Glu Met Glu Cys Leu Asn Gly Gly Pro Leu 
    610                 615                 620                 


Gln Asn Gly Gln Pro Ser Ala Glu Ile Gln Glu Glu Val Ala Leu Thr 
625                 630                 635                 640 


Ser Leu Gly Ser Gly Pro Ala Ala Thr Asn Lys Arg His Ser Thr Ser 
                645                 650                 655     


Asp Lys Met His Phe Pro Arg Ser Ser Leu Gln Pro Ile Thr Thr Leu 
            660                 665                 670         


Gly Lys Ser Glu Phe Gly Glu Val Phe Leu Ala Lys Ala Gln Gly Leu 
        675                 680                 685             


Glu Glu Gly Val Ala Glu Thr Leu Val Leu Val Lys Ser Leu Gln Ser 
    690                 695                 700                 


Lys Asp Glu Gln Gln Gln Leu Asp Phe Arg Arg Glu Leu Glu Met Phe 
705                 710                 715                 720 


Gly Lys Leu Asn His Ala Asn Val Val Arg Leu Leu Gly Leu Cys Arg 
                725                 730                 735     


Glu Ala Glu Pro His Tyr Met Val Leu Glu Tyr Val Asp Leu Gly Asp 
            740                 745                 750         


Leu Lys Gln Phe Leu Arg Ile Ser Lys Ser Lys Asp Glu Lys Leu Lys 
        755                 760                 765             


Ser Gln Pro Leu Ser Thr Lys Gln Lys Val Ala Leu Cys Thr Gln Val 
    770                 775                 780                 


Ala Leu Gly Met Glu His Leu Ser Asn Asn Arg Phe Val His Lys Asp 
785                 790                 795                 800 


Leu Ala Ala Arg Asn Cys Leu Val Ser Ala Gln Arg Gln Val Lys Val 
                805                 810                 815     


Ser Ala Leu Gly Leu Ser Lys Asp Val Tyr Asn Ser Glu Tyr Tyr His 
            820                 825                 830         


Phe Arg Gln Ala Trp Val Pro Leu Arg Trp Met Ser Pro Glu Ala Ile 
        835                 840                 845             


Leu Glu Gly Asp Phe Ser Thr Lys Ser Asp Val Trp Ala Phe Gly Val 
    850                 855                 860                 


Leu Met Trp Glu Val Phe Thr His Gly Glu Met Pro His Gly Gly Gln 
865                 870                 875                 880 


Ala Asp Asp Glu Val Leu Ala Asp Leu Gln Ala Gly Lys Ala Arg Leu 
                885                 890                 895     


Pro Gln Pro Glu Gly Cys Pro Ser Lys Leu Tyr Arg Leu Met Gln Arg 
            900                 905                 910         


Cys Trp Ala Leu Ser Pro Lys Asp Arg Pro Ser Phe Ser Glu Ile Ala 
        915                 920                 925             


Ser Ala Leu Gly Asp Ser Thr Val Asp Ser Lys Pro 
    930                 935                 940 


<210>  6127
<211>  1014
<212>  PRT
<213>  Homo sapiens

<400>  6127

Met Gly Ala Ala Arg Gly Ser Pro Ala Arg Pro Arg Arg Leu Pro Leu 
1               5                   10                  15      


Leu Ser Val Leu Leu Leu Pro Leu Leu Gly Gly Thr Gln Thr Ala Ile 
            20                  25                  30          


Val Phe Ile Lys Gln Pro Ser Ser Gln Asp Ala Leu Gln Gly Arg Arg 
        35                  40                  45              


Ala Leu Leu Arg Cys Glu Val Glu Ala Pro Gly Pro Val His Val Tyr 
    50                  55                  60                  


Trp Leu Leu Asp Gly Ala Pro Val Gln Asp Thr Glu Arg Arg Phe Ala 
65                  70                  75                  80  


Gln Gly Ser Ser Leu Ser Phe Ala Ala Val Asp Arg Leu Gln Asp Ser 
                85                  90                  95      


Gly Thr Phe Gln Cys Val Ala Arg Asp Asp Val Thr Gly Glu Glu Ala 
            100                 105                 110         


Arg Ser Ala Asn Ala Ser Phe Asn Ile Lys Trp Ile Glu Ala Gly Pro 
        115                 120                 125             


Val Val Leu Lys His Pro Ala Ser Glu Ala Glu Ile Gln Pro Gln Thr 
    130                 135                 140                 


Gln Val Thr Leu Arg Cys His Ile Asp Gly His Pro Arg Pro Thr Tyr 
145                 150                 155                 160 


Gln Trp Phe Arg Asp Gly Thr Pro Leu Ser Asp Gly Gln Ser Asn His 
                165                 170                 175     


Thr Val Ser Ser Lys Glu Arg Asn Leu Thr Leu Arg Pro Ala Gly Pro 
            180                 185                 190         


Glu His Ser Gly Leu Tyr Ser Cys Cys Ala His Ser Ala Phe Gly Gln 
        195                 200                 205             


Ala Cys Ser Ser Gln Asn Phe Thr Leu Ser Ile Ala Asp Glu Ser Phe 
    210                 215                 220                 


Ala Arg Val Val Leu Ala Pro Gln Asp Val Val Val Ala Arg Tyr Glu 
225                 230                 235                 240 


Glu Ala Met Phe His Cys Gln Phe Ser Ala Gln Pro Pro Pro Ser Leu 
                245                 250                 255     


Gln Trp Leu Phe Glu Asp Glu Thr Pro Ile Thr Asn Arg Ser Arg Pro 
            260                 265                 270         


Pro His Leu Arg Arg Ala Thr Val Phe Ala Asn Gly Ser Leu Leu Leu 
        275                 280                 285             


Thr Gln Val Arg Pro Arg Asn Ala Gly Ile Tyr Arg Cys Ile Gly Gln 
    290                 295                 300                 


Gly Gln Arg Gly Pro Pro Ile Ile Leu Glu Ala Thr Leu His Leu Ala 
305                 310                 315                 320 


Glu Ile Glu Asp Met Pro Leu Phe Glu Pro Arg Val Phe Thr Ala Gly 
                325                 330                 335     


Ser Glu Glu Arg Val Thr Cys Leu Pro Pro Lys Gly Leu Pro Glu Pro 
            340                 345                 350         


Ser Val Trp Trp Glu His Ala Gly Val Arg Leu Pro Thr His Gly Arg 
        355                 360                 365             


Val Tyr Gln Lys Gly His Glu Leu Val Leu Ala Asn Ile Ala Glu Ser 
    370                 375                 380                 


Asp Ala Gly Val Tyr Thr Cys His Ala Ala Asn Leu Ala Gly Gln Arg 
385                 390                 395                 400 


Arg Gln Asp Val Asn Ile Thr Val Ala Thr Val Pro Ser Trp Leu Lys 
                405                 410                 415     


Lys Pro Gln Asp Ser Gln Leu Glu Glu Gly Lys Pro Gly Tyr Leu Asp 
            420                 425                 430         


Cys Leu Thr Gln Ala Thr Pro Lys Pro Thr Val Val Trp Tyr Arg Asn 
        435                 440                 445             


Gln Met Leu Ile Ser Glu Asp Ser Arg Phe Glu Val Phe Lys Asn Gly 
    450                 455                 460                 


Thr Leu Arg Ile Asn Ser Val Glu Val Tyr Asp Gly Thr Trp Tyr Arg 
465                 470                 475                 480 


Cys Met Ser Ser Thr Pro Ala Gly Ser Ile Glu Ala Gln Ala Arg Val 
                485                 490                 495     


Gln Val Leu Glu Lys Leu Lys Phe Thr Pro Pro Pro Gln Pro Gln Gln 
            500                 505                 510         


Cys Met Glu Phe Asp Lys Glu Ala Thr Val Pro Cys Ser Ala Thr Gly 
        515                 520                 525             


Arg Glu Lys Pro Thr Ile Lys Trp Glu Arg Ala Asp Gly Ser Ser Leu 
    530                 535                 540                 


Pro Glu Trp Val Thr Asp Asn Ala Gly Thr Leu His Phe Ala Arg Val 
545                 550                 555                 560 


Thr Arg Asp Asp Ala Gly Asn Tyr Thr Cys Ile Ala Ser Asn Gly Pro 
                565                 570                 575     


Gln Gly Gln Ile Arg Ala His Val Gln Leu Thr Val Ala Val Phe Ile 
            580                 585                 590         


Thr Phe Lys Val Glu Pro Glu Arg Thr Thr Val Tyr Gln Gly His Thr 
        595                 600                 605             


Ala Leu Leu Gln Cys Glu Ala Gln Gly Asp Pro Lys Pro Leu Ile Gln 
    610                 615                 620                 


Trp Lys Asp Lys Pro Val Pro Glu Glu Ser Glu Gly Pro Gly Ser Pro 
625                 630                 635                 640 


Pro Pro Tyr Lys Met Ile Gln Thr Ile Gly Leu Ser Val Gly Ala Ala 
                645                 650                 655     


Val Ala Tyr Ile Ile Ala Val Leu Gly Leu Met Phe Tyr Cys Lys Lys 
            660                 665                 670         


Arg Cys Lys Ala Lys Arg Leu Gln Lys Gln Pro Glu Gly Glu Glu Pro 
        675                 680                 685             


Glu Met Glu Cys Leu Asn Gly Gly Pro Leu Gln Asn Gly Gln Pro Ser 
    690                 695                 700                 


Ala Glu Ile Gln Glu Glu Val Ala Leu Thr Ser Leu Gly Ser Gly Pro 
705                 710                 715                 720 


Ala Ala Thr Asn Lys Arg His Ser Thr Ser Asp Lys Met His Phe Pro 
                725                 730                 735     


Arg Ser Ser Leu Gln Pro Ile Thr Thr Leu Gly Lys Ser Glu Phe Gly 
            740                 745                 750         


Glu Val Phe Leu Ala Lys Ala Gln Gly Leu Glu Glu Gly Val Ala Glu 
        755                 760                 765             


Thr Leu Val Leu Val Lys Ser Leu Gln Ser Lys Asp Glu Gln Gln Gln 
    770                 775                 780                 


Leu Asp Phe Arg Arg Glu Leu Glu Met Phe Gly Lys Leu Asn His Ala 
785                 790                 795                 800 


Asn Val Val Arg Leu Leu Gly Leu Cys Arg Glu Ala Glu Pro His Tyr 
                805                 810                 815     


Met Val Leu Glu Tyr Val Asp Leu Gly Asp Leu Lys Gln Phe Leu Arg 
            820                 825                 830         


Ile Ser Lys Ser Lys Asp Glu Lys Leu Lys Ser Gln Pro Leu Ser Thr 
        835                 840                 845             


Lys Gln Lys Val Ala Leu Cys Thr Gln Val Ala Leu Gly Met Glu His 
    850                 855                 860                 


Leu Ser Asn Asn Arg Phe Val His Lys Asp Leu Ala Ala Arg Asn Cys 
865                 870                 875                 880 


Leu Val Ser Ala Gln Arg Gln Val Lys Val Ser Ala Leu Gly Leu Ser 
                885                 890                 895     


Lys Asp Val Tyr Asn Ser Glu Tyr Tyr His Phe Arg Gln Ala Trp Val 
            900                 905                 910         


Pro Leu Arg Trp Met Ser Pro Glu Ala Ile Leu Glu Gly Asp Phe Ser 
        915                 920                 925             


Thr Lys Ser Asp Val Trp Ala Phe Gly Val Leu Met Trp Glu Val Phe 
    930                 935                 940                 


Thr His Gly Glu Met Pro His Gly Gly Gln Ala Asp Asp Glu Val Leu 
945                 950                 955                 960 


Ala Asp Leu Gln Ala Gly Lys Ala Arg Leu Pro Gln Pro Glu Gly Cys 
                965                 970                 975     


Pro Ser Lys Leu Tyr Arg Leu Met Gln Arg Cys Trp Ala Leu Ser Pro 
            980                 985                 990         


Lys Asp Arg Pro Ser Phe Ser Glu  Ile Ala Ser Ala Leu  Gly Asp Ser 
        995                 1000                 1005             


Thr Val  Asp Ser Lys Pro 
    1010                 


<210>  6128
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  6128

Met Gly Arg Arg Cys Cys Arg Arg Arg Val Leu Ala Ala Ala Cys Leu 
1               5                   10                  15      


Gly Ala Ala Leu Leu Leu Leu Cys Ala Ala Pro Arg Ser Leu Arg Pro 
            20                  25                  30          


Ala Phe Gly Asn Arg Ala Leu Gly Ser Ser Trp Leu Gly Gly Glu Lys 
        35                  40                  45              


Arg Ser Pro Leu Gln Lys Leu Tyr Asp Leu Asp Gln Asp Pro Arg Ser 
    50                  55                  60                  


Thr Leu Ala Lys Val His Arg Gln Arg Arg Asp Leu Leu Asn Ser Ala 
65                  70                  75                  80  


Cys Ser Arg His Ser Arg Arg Gln Arg Leu Leu Gln Pro Glu Asp Leu 
                85                  90                  95      


Arg His Val Leu Val Asp Asp Ala His Gly Leu Leu Tyr Cys Tyr Val 
            100                 105                 110         


Pro Lys Val Ala Cys Thr Asn Trp Lys Arg Val Leu Leu Ala Leu Ser 
        115                 120                 125             


Gly Gln Ala Arg Gly Asp Pro Arg Ala Ile Ser Ala Gln Glu Ala His 
    130                 135                 140                 


Ala Pro Gly Arg Leu Pro Ser Leu Ala Asp Phe Ser Pro Ala Glu Ile 
145                 150                 155                 160 


Asn Arg Arg Leu Arg Ala Tyr Leu Ala Phe Leu Phe Val Arg Glu Pro 
                165                 170                 175     


Phe Glu Arg Leu Ala Ser Ala Tyr Arg Asn Lys Leu Ala Arg Pro Tyr 
            180                 185                 190         


Ser Ala Ala Phe Gln Arg Arg Tyr Gly Ala Arg Ile Val Gln Arg Leu 
        195                 200                 205             


Arg Pro Arg Ala Leu Pro Asp Ala Arg Ala Arg Gly His Asp Val Arg 
    210                 215                 220                 


Phe Ala Glu Phe Leu Ala Tyr Leu Leu Asp Pro Arg Thr Arg Arg Glu 
225                 230                 235                 240 


Glu Pro Phe Asn Glu His Trp Glu Arg Ala His Ala Leu Cys His Pro 
                245                 250                 255     


Cys Arg Leu Arg Tyr Asp Val Val Gly Lys Phe Glu Thr Leu Ala Glu 
            260                 265                 270         


Asp Ala Ala Phe Val Leu Gly Leu Ala Gly Ala Ser Asp Leu Ser Phe 
        275                 280                 285             


Pro Gly Pro Pro Arg Pro Arg Gly Ala Ala Ala Ser Arg Asp Leu Ala 
    290                 295                 300                 


Ala Arg Leu Phe Arg Asp Ile Ser Pro Phe Tyr Gln Arg Arg Leu Phe 
305                 310                 315                 320 


Asp Leu Tyr Lys Met Asp Phe Leu Leu Phe Asn Tyr Ser Ala Pro Ser 
                325                 330                 335     


Tyr Leu Arg Leu Leu 
            340     


<210>  6129
<211>  1714
<212>  PRT
<213>  Homo sapiens

<400>  6129

Met His Leu Arg Ala His Arg Thr Arg Arg Gly Lys Val Ser Pro Thr 
1               5                   10                  15      


Ala Lys Thr Lys Ser Leu Leu His Phe Ile Val Leu Cys Val Ala Gly 
            20                  25                  30          


Val Val Val His Ala Gln Glu Gln Gly Ile Asp Ile Leu His Gln Leu 
        35                  40                  45              


Gly Leu Gly Gly Lys Asp Val Arg His Ser Ser Pro Ala Thr Ala Val 
    50                  55                  60                  


Pro Ser Ala Ser Thr Pro Leu Pro Gln Gly Val His Leu Thr Glu Ser 
65                  70                  75                  80  


Gly Val Ile Phe Lys Asn Asp Ala Tyr Ile Glu Thr Pro Phe Val Lys 
                85                  90                  95      


Ile Leu Pro Val Asn Leu Gly Gln Pro Phe Thr Ile Leu Thr Gly Leu 
            100                 105                 110         


Gln Ser His Arg Val Asn Asn Ala Phe Leu Phe Ser Ile Arg Asn Lys 
        115                 120                 125             


Asn Arg Leu Gln Leu Gly Val Gln Leu Leu Pro Lys Lys Leu Val Val 
    130                 135                 140                 


His Ile Arg Gly Lys Gln Pro Ala Val Phe Asn Tyr Ser Val His Asp 
145                 150                 155                 160 


Glu Gln Trp His Ser Phe Ala Ile Thr Ile Arg Asn Gln Ser Val Ser 
                165                 170                 175     


Met Phe Val Glu Cys Gly Lys Lys Tyr Phe Ser Thr Glu Thr Ile Pro 
            180                 185                 190         


Glu Val Gln Thr Phe Asp Ser Asn Ser Val Phe Thr Leu Gly Ser Met 
        195                 200                 205             


Asn Asn Asn Ser Ile His Phe Glu Gly Ile Val Cys Gln Leu Asp Ile 
    210                 215                 220                 


Ile Pro Ser Ala Glu Ala Ser Ala Asp Tyr Cys Arg Tyr Val Lys Gln 
225                 230                 235                 240 


Gln Cys Arg Gln Ala Asp Lys Tyr Gln Pro Glu Thr Ser Ile Pro Cys 
                245                 250                 255     


Thr Thr Leu Ile Pro Thr Lys Ile Pro Glu His Ser Pro Pro Pro Lys 
            260                 265                 270         


Leu Phe Ala Glu Lys Val Leu Ser Glu Asp Thr Phe Thr Glu Gly Lys 
        275                 280                 285             


Ser Ile Pro Asn Ile Ile Lys Asn Asp Ser Glu Thr Val Tyr Lys Arg 
    290                 295                 300                 


Gln Glu His Gln Ile Ser Arg Ser Gln Leu Ser Ser Leu Gln Ser Gly 
305                 310                 315                 320 


Asn Val Ser Ala Val Asp Leu Thr Asn His Gly Ile Gln Ala Lys Glu 
                325                 330                 335     


Met Ile Thr Glu Glu Asp Thr Gln Thr Asn Phe Ser Leu Ser Val Thr 
            340                 345                 350         


Thr His Arg Ile Ser Glu Ala Lys Met Asn Thr Lys Glu Lys Phe Ser 
        355                 360                 365             


Ser Leu Leu Asn Met Ser Asp Asn Ile Thr Gln His Asp Asp Arg Val 
    370                 375                 380                 


Thr Gly Leu Ser Leu Phe Lys Lys Met Pro Ser Ile Leu Pro Gln Ile 
385                 390                 395                 400 


Lys Gln Asp Thr Ile Thr Asn Leu Lys Lys Ala Ile Thr Ala Asn Leu 
                405                 410                 415     


His Thr Asn Glu Leu Met Glu Met Gln Pro Ile Leu Asn Thr Ser Leu 
            420                 425                 430         


His Arg Val Thr Asn Glu Pro Ser Val Asp Asn His Leu Asp Leu Arg 
        435                 440                 445             


Lys Glu Gly Glu Phe Tyr Pro Asp Ala Thr Tyr Pro Ile Glu Asn Ser 
    450                 455                 460                 


Tyr Glu Thr Glu Leu Tyr Asp Tyr Tyr Tyr Tyr Glu Asp Leu Asn Thr 
465                 470                 475                 480 


Met Leu Glu Met Glu Tyr Leu Arg Gly Pro Lys Gly Asp Thr Gly Pro 
                485                 490                 495     


Pro Gly Pro Pro Gly Pro Ala Gly Ile Pro Gly Pro Ser Gly Lys Arg 
            500                 505                 510         


Gly Pro Arg Gly Ile Pro Gly Pro His Gly Asn Pro Gly Leu Pro Gly 
        515                 520                 525             


Leu Pro Gly Pro Lys Gly Pro Lys Gly Asp Pro Gly Phe Ser Pro Gly 
    530                 535                 540                 


Gln Pro Val Pro Gly Glu Lys Gly Asp Gln Gly Leu Ser Gly Leu Met 
545                 550                 555                 560 


Gly Pro Pro Gly Met Gln Gly Asp Lys Gly Leu Lys Gly His Pro Gly 
                565                 570                 575     


Leu Pro Gly Leu Pro Gly Glu Gln Gly Ile Pro Gly Phe Ala Gly Asn 
            580                 585                 590         


Ile Gly Ser Pro Gly Tyr Pro Gly Arg Gln Gly Leu Ala Gly Pro Glu 
        595                 600                 605             


Gly Asn Pro Gly Pro Lys Gly Ala Gln Gly Phe Ile Gly Ser Pro Gly 
    610                 615                 620                 


Glu Ala Gly Gln Leu Gly Pro Glu Gly Glu Arg Gly Ile Pro Gly Ile 
625                 630                 635                 640 


Arg Gly Lys Lys Gly Phe Lys Gly Arg Gln Gly Phe Pro Gly Asp Phe 
                645                 650                 655     


Gly Asp Arg Gly Pro Ala Gly Leu Asp Gly Ser Pro Gly Leu Val Gly 
            660                 665                 670         


Gly Thr Gly Pro Pro Gly Phe Pro Gly Leu Arg Gly Ser Val Gly Pro 
        675                 680                 685             


Val Gly Pro Ile Gly Pro Ala Gly Ile Pro Gly Pro Met Gly Leu Ser 
    690                 695                 700                 


Gly Asn Lys Gly Leu Pro Gly Ile Lys Gly Asp Lys Gly Glu Gln Gly 
705                 710                 715                 720 


Thr Ala Gly Glu Leu Gly Glu Pro Gly Tyr Pro Gly Asp Lys Gly Ala 
                725                 730                 735     


Val Gly Leu Pro Gly Pro Pro Gly Met Arg Gly Lys Ser Gly Pro Ser 
            740                 745                 750         


Gly Gln Thr Gly Asp Pro Gly Leu Gln Gly Pro Ser Gly Pro Pro Gly 
        755                 760                 765             


Pro Glu Gly Phe Pro Gly Asp Ile Gly Ile Pro Gly Gln Asn Gly Pro 
    770                 775                 780                 


Glu Gly Pro Lys Gly Leu Leu Gly Asn Arg Gly Pro Pro Gly Pro Pro 
785                 790                 795                 800 


Gly Leu Lys Gly Thr Gln Gly Glu Glu Gly Pro Ile Gly Ala Phe Gly 
                805                 810                 815     


Glu Leu Gly Pro Arg Gly Lys Pro Gly Gln Lys Gly Tyr Ala Gly Glu 
            820                 825                 830         


Pro Gly Pro Glu Gly Leu Lys Gly Glu Val Gly Asp Gln Gly Asn Ile 
        835                 840                 845             


Gly Lys Ile Gly Glu Thr Gly Pro Val Gly Leu Pro Gly Glu Val Gly 
    850                 855                 860                 


Met Thr Gly Ser Ile Gly Glu Lys Gly Glu Arg Gly Ser Pro Gly Pro 
865                 870                 875                 880 


Leu Gly Pro Gln Gly Glu Lys Gly Val Met Gly Tyr Pro Gly Pro Pro 
                885                 890                 895     


Gly Val Pro Gly Pro Ile Gly Pro Leu Gly Leu Pro Gly His Val Gly 
            900                 905                 910         


Ala Arg Gly Pro Pro Gly Ser Gln Gly Pro Lys Gly Gln Arg Gly Ser 
        915                 920                 925             


Arg Gly Pro Asp Gly Leu Leu Gly Glu Gln Gly Ile Gln Gly Ala Lys 
    930                 935                 940                 


Gly Glu Lys Gly Asp Gln Gly Lys Arg Gly Pro His Gly Leu Ile Gly 
945                 950                 955                 960 


Lys Thr Gly Asn Pro Gly Glu Arg Gly Phe Gln Gly Lys Pro Gly Leu 
                965                 970                 975     


Gln Gly Leu Pro Gly Ser Thr Gly Asp Arg Gly Leu Pro Gly Glu Pro 
            980                 985                 990         


Gly Leu Arg Gly Leu Gln Gly Asp  Val Gly Pro Pro Gly  Glu Met Gly 
        995                 1000                 1005             


Met Glu  Gly Pro Pro Gly Thr  Glu Gly Glu Ser Gly  Leu Gln Gly 
    1010                 1015                 1020             


Glu Pro  Gly Ala Lys Gly Asp  Val Gly Thr Ala Gly  Ser Val Gly 
    1025                 1030                 1035             


Gly Thr  Gly Glu Pro Gly Leu  Arg Gly Glu Pro Gly  Ala Pro Gly 
    1040                 1045                 1050             


Glu Glu  Gly Leu Gln Gly Lys  Asp Gly Leu Lys Gly  Val Pro Gly 
    1055                 1060                 1065             


Gly Arg  Gly Leu Pro Gly Glu  Asp Gly Glu Lys Gly  Glu Met Gly 
    1070                 1075                 1080             


Leu Pro  Gly Ile Ile Gly Pro  Leu Gly Arg Ser Gly  Gln Thr Gly 
    1085                 1090                 1095             


Leu Pro  Gly Pro Glu Gly Ile  Val Gly Ile Pro Gly  Gln Arg Gly 
    1100                 1105                 1110             


Arg Pro  Gly Lys Lys Gly Asp  Lys Gly Gln Ile Gly  Pro Thr Gly 
    1115                 1120                 1125             


Glu Val  Gly Ser Arg Gly Pro  Pro Gly Lys Ile Gly  Lys Ser Gly 
    1130                 1135                 1140             


Pro Lys  Gly Ala Arg Gly Thr  Arg Gly Ala Val Gly  His Leu Gly 
    1145                 1150                 1155             


Leu Met  Gly Pro Asp Gly Glu  Pro Gly Ile Pro Gly  Tyr Arg Gly 
    1160                 1165                 1170             


His Gln  Gly Gln Pro Gly Pro  Ser Gly Leu Pro Gly  Pro Lys Gly 
    1175                 1180                 1185             


Glu Lys  Gly Tyr Pro Gly Glu  Asp Ser Thr Val Leu  Gly Pro Pro 
    1190                 1195                 1200             


Gly Pro  Arg Gly Glu Pro Gly  Pro Val Gly Asp Gln  Gly Glu Arg 
    1205                 1210                 1215             


Gly Glu  Pro Gly Ala Glu Gly  Tyr Lys Gly His Val  Gly Val Pro 
    1220                 1225                 1230             


Gly Leu  Arg Gly Ala Thr Gly  Gln Gln Gly Pro Pro  Gly Glu Pro 
    1235                 1240                 1245             


Gly Asp  Gln Gly Glu Gln Gly  Leu Lys Gly Glu Arg  Gly Ser Glu 
    1250                 1255                 1260             


Gly Asn  Lys Gly Lys Lys Gly  Ala Pro Gly Pro Ser  Gly Lys Pro 
    1265                 1270                 1275             


Gly Ile  Pro Gly Leu Gln Gly  Leu Leu Gly Pro Lys  Gly Ile Gln 
    1280                 1285                 1290             


Gly Tyr  His Gly Ala Asp Gly  Ile Ser Gly Asn Pro  Gly Lys Ile 
    1295                 1300                 1305             


Gly Pro  Pro Gly Lys Gln Gly  Leu Pro Gly Ile Arg  Gly Gly Pro 
    1310                 1315                 1320             


Gly Arg  Thr Gly Leu Ala Gly  Ala Pro Gly Pro Pro  Gly Val Lys 
    1325                 1330                 1335             


Gly Ser  Ser Gly Leu Pro Gly  Ser Pro Gly Ile Gln  Gly Pro Lys 
    1340                 1345                 1350             


Gly Glu  Gln Gly Leu Pro Gly  Gln Pro Gly Ile Gln  Gly Lys Arg 
    1355                 1360                 1365             


Gly His  Arg Gly Ala Gln Gly  Asp Gln Gly Pro Cys  Gly Asp Pro 
    1370                 1375                 1380             


Gly Leu  Lys Gly Gln Pro Gly  Glu Tyr Gly Val Gln  Gly Leu Thr 
    1385                 1390                 1395             


Gly Phe  Gln Gly Phe Pro Gly  Pro Lys Gly Pro Glu  Gly Asp Ala 
    1400                 1405                 1410             


Gly Ile  Val Gly Ile Ser Gly  Pro Lys Gly Pro Ile  Gly His Arg 
    1415                 1420                 1425             


Gly Asn  Thr Gly Pro Leu Gly  Arg Glu Gly Ile Ile  Gly Pro Thr 
    1430                 1435                 1440             


Gly Arg  Thr Gly Pro Arg Gly  Glu Lys Gly Phe Arg  Gly Glu Thr 
    1445                 1450                 1455             


Gly Pro  Gln Gly Pro Arg Gly  Gln Pro Gly Pro Pro  Gly Pro Pro 
    1460                 1465                 1470             


Gly Ala  Pro Gly Pro Arg Lys  Gln Met Asp Ile Asn  Ala Ala Ile 
    1475                 1480                 1485             


Gln Ala  Leu Ile Glu Ser Asn  Thr Ala Leu Gln Met  Glu Ser Tyr 
    1490                 1495                 1500             


Gln Asn  Thr Glu Val Thr Leu  Ile Asp His Ser Glu  Glu Ile Phe 
    1505                 1510                 1515             


Lys Thr  Leu Asn Tyr Leu Ser  Asn Leu Leu His Ser  Ile Lys Asn 
    1520                 1525                 1530             


Pro Leu  Gly Thr Arg Asp Asn  Pro Ala Arg Ile Cys  Lys Asp Leu 
    1535                 1540                 1545             


Leu Asn  Cys Glu Gln Lys Val  Ser Asp Gly Lys Tyr  Trp Ile Asp 
    1550                 1555                 1560             


Pro Asn  Leu Gly Cys Pro Ser  Asp Ala Ile Glu Val  Phe Cys Asn 
    1565                 1570                 1575             


Phe Ser  Ala Gly Gly Gln Thr  Cys Leu Pro Pro Val  Ser Val Thr 
    1580                 1585                 1590             


Lys Leu  Glu Phe Gly Val Gly  Lys Val Gln Met Asn  Phe Leu His 
    1595                 1600                 1605             


Leu Leu  Ser Ser Glu Ala Thr  His Ile Ile Thr Ile  His Cys Leu 
    1610                 1615                 1620             


Asn Thr  Pro Arg Trp Thr Ser  Thr Gln Thr Ser Gly  Pro Gly Leu 
    1625                 1630                 1635             


Pro Ile  Gly Phe Lys Gly Trp  Asn Gly Gln Ile Phe  Lys Val Asn 
    1640                 1645                 1650             


Thr Leu  Leu Glu Pro Lys Val  Leu Ser Asp Asp Cys  Lys Ile Gln 
    1655                 1660                 1665             


Asp Gly  Ser Trp His Lys Ala  Thr Phe Leu Phe His  Thr Gln Glu 
    1670                 1675                 1680             


Pro Asn  Gln Leu Pro Val Ile  Glu Val Gln Lys Leu  Pro His Leu 
    1685                 1690                 1695             


Lys Thr  Glu Arg Lys Tyr Tyr  Ile Asp Ser Ser Ser  Val Cys Phe 
    1700                 1705                 1710             


Leu 
    


<210>  6130
<211>  567
<212>  PRT
<213>  Homo sapiens

<400>  6130

Met Ala Pro Leu Ala Leu His Leu Leu Val Leu Val Pro Ile Leu Leu 
1               5                   10                  15      


Ser Leu Val Ala Ser Gln Asp Trp Lys Ala Glu Arg Ser Gln Asp Pro 
            20                  25                  30          


Phe Glu Lys Cys Met Gln Asp Pro Asp Tyr Glu Gln Leu Leu Lys Val 
        35                  40                  45              


Val Thr Trp Gly Leu Asn Arg Thr Leu Lys Pro Gln Arg Val Ile Val 
    50                  55                  60                  


Val Gly Ala Gly Val Ala Gly Leu Val Ala Ala Lys Val Leu Ser Asp 
65                  70                  75                  80  


Ala Gly His Lys Val Thr Ile Leu Glu Ala Asp Asn Arg Ile Gly Gly 
                85                  90                  95      


Arg Ile Phe Thr Tyr Arg Asp Gln Asn Thr Gly Trp Ile Gly Glu Leu 
            100                 105                 110         


Gly Ala Met Arg Met Pro Ser Ser His Arg Ile Leu His Lys Leu Cys 
        115                 120                 125             


Gln Gly Leu Gly Leu Asn Leu Thr Lys Phe Thr Gln Tyr Asp Lys Asn 
    130                 135                 140                 


Thr Trp Thr Glu Val His Glu Val Lys Leu Arg Asn Tyr Val Val Glu 
145                 150                 155                 160 


Lys Val Pro Glu Lys Leu Gly Tyr Ala Leu Arg Pro Gln Glu Lys Gly 
                165                 170                 175     


His Ser Pro Glu Asp Ile Tyr Gln Met Ala Leu Asn Gln Ala Leu Lys 
            180                 185                 190         


Asp Leu Lys Ala Leu Gly Cys Arg Lys Ala Met Lys Lys Phe Glu Arg 
        195                 200                 205             


His Thr Leu Leu Glu Tyr Leu Leu Gly Glu Gly Asn Leu Ser Arg Pro 
    210                 215                 220                 


Ala Val Gln Leu Leu Gly Asp Val Met Ser Glu Asp Gly Phe Phe Tyr 
225                 230                 235                 240 


Leu Ser Phe Ala Glu Ala Leu Arg Ala His Ser Cys Leu Ser Asp Arg 
                245                 250                 255     


Leu Gln Tyr Ser Arg Ile Val Gly Gly Trp Asp Leu Leu Pro Arg Ala 
            260                 265                 270         


Leu Leu Ser Ser Leu Ser Gly Leu Val Leu Leu Asn Ala Pro Val Val 
        275                 280                 285             


Ala Met Thr Gln Gly Pro His Asp Val His Val Gln Ile Glu Thr Ser 
    290                 295                 300                 


Pro Pro Ala Arg Asn Leu Lys Val Leu Lys Ala Asp Val Val Leu Leu 
305                 310                 315                 320 


Thr Ala Ser Gly Pro Ala Val Lys Arg Ile Thr Phe Ser Pro Pro Leu 
                325                 330                 335     


Pro Arg His Met Gln Glu Ala Leu Arg Arg Leu His Tyr Val Pro Ala 
            340                 345                 350         


Thr Lys Val Phe Leu Ser Phe Arg Arg Pro Phe Trp Arg Glu Glu His 
        355                 360                 365             


Ile Glu Gly Gly His Ser Asn Thr Asp Arg Pro Ser Arg Met Ile Phe 
    370                 375                 380                 


Tyr Pro Pro Pro Arg Glu Gly Ala Leu Leu Leu Ala Ser Tyr Thr Trp 
385                 390                 395                 400 


Ser Asp Ala Ala Ala Ala Phe Ala Gly Leu Ser Arg Glu Glu Ala Leu 
                405                 410                 415     


Arg Leu Ala Leu Asp Asp Val Ala Ala Leu His Gly Pro Val Val Arg 
            420                 425                 430         


Gln Leu Trp Asp Gly Thr Gly Val Val Lys Arg Trp Ala Glu Asp Gln 
        435                 440                 445             


His Ser Gln Gly Gly Phe Val Val Gln Pro Pro Ala Leu Trp Gln Thr 
    450                 455                 460                 


Glu Lys Asp Asp Trp Thr Val Pro Tyr Gly Arg Ile Tyr Phe Ala Gly 
465                 470                 475                 480 


Glu His Thr Ala Tyr Pro His Gly Trp Val Glu Thr Ala Val Lys Ser 
                485                 490                 495     


Ala Leu Arg Ala Ala Ile Lys Ile Asn Ser Arg Lys Gly Pro Ala Ser 
            500                 505                 510         


Asp Thr Ala Ser Pro Glu Gly His Ala Ser Asp Met Glu Gly Gln Gly 
        515                 520                 525             


His Val His Gly Val Ala Ser Ser Pro Ser His Asp Leu Ala Lys Glu 
    530                 535                 540                 


Glu Gly Ser His Pro Pro Val Gln Gly Gln Leu Ser Leu Gln Asn Thr 
545                 550                 555                 560 


Thr His Thr Arg Thr Ser His 
                565         


<210>  6131
<211>  602
<212>  PRT
<213>  Homo sapiens

<400>  6131

Met Asp Ser Leu Gln Asp Thr Val Ala Leu Asp His Gly Gly Cys Cys 
1               5                   10                  15      


Pro Ala Leu Ser Arg Leu Val Pro Arg Gly Phe Gly Thr Glu Met Trp 
            20                  25                  30          


Thr Leu Phe Ala Leu Ser Gly Pro Leu Phe Leu Phe Gln Val Leu Thr 
        35                  40                  45              


Phe Met Ile Tyr Ile Val Ser Thr Val Phe Cys Gly His Leu Gly Lys 
    50                  55                  60                  


Val Glu Leu Ala Ser Val Thr Leu Ala Val Ala Phe Val Asn Val Cys 
65                  70                  75                  80  


Gly Val Ser Val Gly Val Gly Leu Ser Ser Ala Cys Asp Thr Leu Met 
                85                  90                  95      


Ser Gln Ser Phe Gly Ser Pro Asn Lys Lys His Val Gly Val Ile Leu 
            100                 105                 110         


Gln Arg Gly Ala Leu Val Leu Leu Leu Cys Cys Leu Pro Cys Trp Ala 
        115                 120                 125             


Leu Phe Leu Asn Thr Gln His Ile Leu Leu Leu Phe Arg Gln Asp Pro 
    130                 135                 140                 


Asp Val Ser Arg Leu Thr Gln Asp Tyr Val Met Ile Phe Ile Pro Gly 
145                 150                 155                 160 


Leu Pro Val Ile Phe Leu Tyr Asn Leu Leu Ala Lys Tyr Leu Gln Asn 
                165                 170                 175     


Gln Gly Trp Leu Lys Gly Gln Glu Glu Glu Ser Pro Phe Gln Thr Pro 
            180                 185                 190         


Gly Leu Ser Ile Leu His Pro Ser His Ser His Leu Ser Arg Ala Ser 
        195                 200                 205             


Phe His Leu Phe Gln Lys Ile Thr Trp Pro Gln Val Leu Ser Gly Val 
    210                 215                 220                 


Val Gly Asn Cys Val Asn Gly Val Ala Asn Tyr Ala Leu Val Ser Val 
225                 230                 235                 240 


Leu Asn Leu Gly Val Arg Gly Ser Ala Tyr Ala Asn Ile Ile Ser Gln 
                245                 250                 255     


Phe Ala Gln Thr Val Phe Leu Leu Leu Tyr Ile Val Leu Lys Lys Leu 
            260                 265                 270         


His Leu Glu Thr Trp Ala Gly Trp Ser Ser Gln Cys Leu Gln Asp Trp 
        275                 280                 285             


Gly Pro Phe Phe Ser Leu Ala Val Pro Ser Met Leu Met Ile Cys Val 
    290                 295                 300                 


Glu Trp Trp Ala Tyr Glu Ile Gly Ser Phe Leu Met Gly Leu Leu Ser 
305                 310                 315                 320 


Val Val Asp Leu Ser Ala Gln Ala Val Ile Tyr Glu Val Ala Thr Val 
                325                 330                 335     


Thr Tyr Met Ile Pro Leu Gly Leu Ser Ile Gly Val Cys Val Arg Val 
            340                 345                 350         


Gly Met Ala Leu Gly Ala Ala Asp Thr Val Gln Ala Lys Arg Ser Ala 
        355                 360                 365             


Val Ser Gly Val Leu Ser Ile Val Gly Ile Ser Leu Val Leu Gly Thr 
    370                 375                 380                 


Leu Ile Ser Ile Leu Lys Asn Gln Leu Gly His Ile Phe Thr Asn Asp 
385                 390                 395                 400 


Glu Asp Val Ile Ala Leu Val Ser Gln Val Leu Pro Val Tyr Ser Val 
                405                 410                 415     


Phe His Val Phe Glu Ala Ile Cys Cys Val Tyr Gly Gly Val Leu Arg 
            420                 425                 430         


Gly Thr Gly Lys Gln Ala Phe Gly Ala Ala Val Asn Ala Ile Thr Tyr 
        435                 440                 445             


Tyr Ile Ile Gly Leu Pro Leu Gly Ile Leu Leu Thr Phe Val Val Arg 
    450                 455                 460                 


Met Arg Ile Met Gly Leu Trp Leu Gly Met Leu Ala Cys Val Phe Leu 
465                 470                 475                 480 


Ala Thr Ala Ala Phe Val Ala Tyr Thr Ala Arg Leu Asp Trp Lys Leu 
                485                 490                 495     


Ala Ala Glu Glu Ala Lys Lys His Ser Gly Arg Gln Gln Gln Gln Arg 
            500                 505                 510         


Ala Glu Ser Thr Ala Thr Arg Pro Gly Pro Glu Lys Ala Val Leu Ser 
        515                 520                 525             


Ser Val Ala Thr Gly Ser Ser Pro Gly Ile Thr Leu Thr Thr Tyr Ser 
    530                 535                 540                 


Arg Ser Glu Cys His Val Asp Phe Phe Arg Thr Pro Glu Glu Ala His 
545                 550                 555                 560 


Ala Leu Ser Ala Pro Thr Ser Arg Leu Ser Val Lys Gln Leu Val Ile 
                565                 570                 575     


Arg Arg Gly Ala Ala Leu Gly Ala Ala Ser Ala Thr Leu Met Val Gly 
            580                 585                 590         


Leu Thr Val Arg Ile Leu Ala Thr Arg His 
        595                 600         


<210>  6132
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  6132

Met Ala Gln Ala Val Trp Ser Arg Leu Gly Arg Ile Leu Trp Leu Ala 
1               5                   10                  15      


Cys Leu Leu Pro Trp Ala Pro Ala Gly Val Ala Ala Gly Leu Tyr Glu 
            20                  25                  30          


Leu Asn Leu Thr Thr Asp Ser Pro Ala Thr Thr Gly Ala Val Val Thr 
        35                  40                  45              


Ile Ser Ala Ser Leu Val Ala Lys Asp Asn Gly Ser Leu Ala Leu Pro 
    50                  55                  60                  


Ala Asp Ala His Leu Tyr Arg Phe His Trp Ile His Thr Pro Leu Val 
65                  70                  75                  80  


Leu Thr Gly Lys Met Glu Lys Gly Leu Ser Ser Thr Ile Arg Val Val 
                85                  90                  95      


Gly His Val Pro Gly Glu Phe Pro Val Ser Val Trp Val Thr Ala Ala 
            100                 105                 110         


Asp Cys Trp Met Cys Gln Pro Val Ala Arg Gly Phe Val Val Leu Pro 
        115                 120                 125             


Ile Thr Glu Phe Leu Val Gly Asp Leu Val Val Thr Gln Asn Thr Ser 
    130                 135                 140                 


Leu Pro Trp Pro Ser Ser Tyr Leu Thr Lys Thr Val Leu Lys Val Ser 
145                 150                 155                 160 


Phe Leu Leu His Asp Pro Ser Asn Phe Leu Lys Thr Ala Leu Phe Leu 
                165                 170                 175     


Tyr Ser Trp Asp Phe Gly Asp Gly Thr Gln Met Val Thr Glu Asp Ser 
            180                 185                 190         


Val Val Tyr Tyr Asn Tyr Ser Ile Ile Gly Thr Phe Thr Val Lys Leu 
        195                 200                 205             


Lys Val Val Ala Glu Trp Glu Glu Val Glu Pro Asp Ala Thr Arg Ala 
    210                 215                 220                 


Val Lys Gln Lys Thr Gly Asp Phe Ser Ala Ser Leu Lys Leu Gln Glu 
225                 230                 235                 240 


Thr Leu Arg Gly Ile Gln Val Leu Gly Pro Thr Leu Ile Gln Thr Phe 
                245                 250                 255     


Gln Lys Met Thr Val Thr Leu Asn Phe Leu Gly Ser Pro Pro Leu Thr 
            260                 265                 270         


Val Cys Trp Arg Leu Lys Pro Glu Cys Leu Pro Leu Glu Glu Gly Glu 
        275                 280                 285             


Cys His Pro Val Ser Val Ala Ser Thr Ala Tyr Asn Leu Thr His Thr 
    290                 295                 300                 


Phe Arg Asp Pro Gly Asp Tyr Cys Phe Ser Ile Arg Ala Glu Asn Ile 
305                 310                 315                 320 


Ile Ser Lys Thr His Gln Tyr His Lys Ile Gln Val Trp Pro Ser Arg 
                325                 330                 335     


Ile Gln Pro Ala Val Phe Ala Phe Pro Cys Ala Thr Leu Ile Thr Val 
            340                 345                 350         


Met Leu Ala Phe Ile Met Tyr Met Thr Leu Arg Asn Ala Thr Gln Gln 
        355                 360                 365             


Lys Asp Met Val Glu Asn Pro Glu Pro Pro Ser Gly Val Arg Cys Cys 
    370                 375                 380                 


Cys Gln Met Cys Cys Gly Pro Phe Leu Leu Glu Thr Pro Ser Glu Tyr 
385                 390                 395                 400 


Leu Glu Ile Val Arg Glu Asn His Gly Leu Leu Pro Pro Leu Tyr Lys 
                405                 410                 415     


Ser Val Lys Thr Tyr Thr Val 
            420             


<210>  6133
<211>  765
<212>  PRT
<213>  Homo sapiens

<400>  6133

Met Gly Gly Arg Val Phe Leu Val Phe Leu Ala Phe Cys Val Trp Leu 
1               5                   10                  15      


Thr Leu Pro Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp 
            20                  25                  30          


Cys Pro Gln Asp Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn 
        35                  40                  45              


Pro Gly Phe Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Met Glu Thr 
    50                  55                  60                  


Cys Asp Asp Ile Asn Glu Cys Ala Thr Leu Ser Lys Val Ser Cys Gly 
65                  70                  75                  80  


Lys Phe Ser Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys 
                85                  90                  95      


Ser Pro Gly Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu 
            100                 105                 110         


Ser Glu Asn Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg 
        115                 120                 125             


Leu Cys Lys Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr 
    130                 135                 140                 


Cys Gln Cys Leu Pro Gly Phe Lys Leu Lys Pro Glu Asp Pro Lys Leu 
145                 150                 155                 160 


Cys Thr Asp Val Asn Glu Cys Thr Ser Gly Gln Asn Pro Cys His Ser 
                165                 170                 175     


Ser Thr His Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg 
            180                 185                 190         


Pro Gly Trp Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Thr 
        195                 200                 205             


Val Cys Glu Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp 
    210                 215                 220                 


Ser Ser Thr Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys 
225                 230                 235                 240 


Arg Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp 
                245                 250                 255     


Thr Val Cys Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly 
            260                 265                 270         


Val His Ser Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu 
        275                 280                 285             


Gly Arg Asp Tyr Lys Pro Gly Leu Ala Asn Asn Thr Ile Gln Ser Ile 
    290                 295                 300                 


Leu Gln Ala Leu Asp Glu Leu Leu Glu Ala Pro Gly Asp Leu Glu Thr 
305                 310                 315                 320 


Leu Pro Arg Leu Gln Gln His Cys Val Ala Ser His Leu Leu Asp Gly 
                325                 330                 335     


Leu Glu Asp Val Leu Arg Gly Leu Ser Lys Asn Leu Ser Asn Gly Leu 
            340                 345                 350         


Leu Asn Phe Ser Tyr Pro Ala Gly Thr Glu Leu Ser Leu Glu Val Gln 
        355                 360                 365             


Lys Gln Val Asp Arg Ser Val Thr Leu Arg Gln Asn Gln Ala Val Met 
    370                 375                 380                 


Gln Leu Asp Trp Asn Gln Ala Gln Lys Ser Gly Asp Pro Gly Pro Ser 
385                 390                 395                 400 


Val Val Gly Leu Val Ser Ile Pro Gly Met Gly Lys Leu Leu Ala Glu 
                405                 410                 415     


Ala Pro Leu Val Leu Glu Pro Glu Lys Gln Met Leu Leu His Glu Thr 
            420                 425                 430         


His Gln Gly Leu Leu Gln Asp Gly Ser Pro Ile Leu Leu Ser Asp Val 
        435                 440                 445             


Ile Ser Ala Phe Leu Ser Asn Asn Asp Thr Gln Asn Leu Ser Ser Pro 
    450                 455                 460                 


Val Thr Phe Thr Phe Ser His Arg Glu Glu Asp Pro Val Leu Thr Val 
465                 470                 475                 480 


Ile Thr Tyr Met Gly Leu Ser Val Ser Leu Leu Cys Leu Leu Leu Ala 
                485                 490                 495     


Ala Leu Thr Phe Leu Leu Cys Lys Ala Ile Gln Asn Thr Ser Thr Ser 
            500                 505                 510         


Leu His Leu Gln Leu Ser Leu Cys Leu Phe Leu Ala His Leu Leu Phe 
        515                 520                 525             


Leu Val Ala Ile Asp Gln Thr Gly His Lys Val Leu Cys Ser Ile Ile 
    530                 535                 540                 


Ala Gly Thr Leu His Tyr Leu Tyr Leu Ala Thr Leu Thr Trp Met Leu 
545                 550                 555                 560 


Leu Glu Ala Leu Tyr Leu Phe Leu Thr Ala Arg Asn Leu Thr Val Val 
                565                 570                 575     


Asn Tyr Ser Ser Ile Asn Arg Phe Met Lys Lys Leu Met Phe Pro Val 
            580                 585                 590         


Gly Tyr Gly Val Pro Ala Val Thr Val Ala Ile Ser Ala Ala Ser Arg 
        595                 600                 605             


Pro His Leu Tyr Gly Thr Pro Ser Arg Cys Trp Leu Gln Pro Glu Lys 
    610                 615                 620                 


Gly Phe Ile Trp Gly Phe Leu Gly Pro Val Cys Ala Ile Phe Ser Val 
625                 630                 635                 640 


Asn Leu Val Leu Phe Leu Val Thr Leu Trp Ile Leu Lys Asn Arg Leu 
                645                 650                 655     


Ser Ser Leu Asn Ser Glu Val Ser Thr Leu Arg Asn Thr Arg Met Leu 
            660                 665                 670         


Ala Phe Lys Ala Thr Ala Gln Leu Phe Ile Leu Gly Cys Thr Trp Cys 
        675                 680                 685             


Leu Gly Ile Leu Gln Val Gly Pro Ala Ala Arg Val Met Ala Tyr Leu 
    690                 695                 700                 


Phe Thr Ile Ile Asn Ser Leu Gln Gly Val Phe Ile Phe Leu Val Tyr 
705                 710                 715                 720 


Cys Leu Leu Ser Gln Gln Val Arg Glu Gln Tyr Gly Lys Trp Ser Lys 
                725                 730                 735     


Gly Ile Arg Lys Leu Lys Thr Glu Ser Glu Met His Thr Leu Ser Ser 
            740                 745                 750         


Ser Ala Lys Ala Asp Thr Ser Lys Pro Ser Thr Val Asn 
        755                 760                 765 


<210>  6134
<211>  765
<212>  PRT
<213>  Homo sapiens

<400>  6134

Met Gly Gly Arg Val Phe Leu Val Phe Leu Ala Phe Cys Val Trp Leu 
1               5                   10                  15      


Thr Leu Pro Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp 
            20                  25                  30          


Cys Pro Gln Asp Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn 
        35                  40                  45              


Pro Gly Phe Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Met Glu Thr 
    50                  55                  60                  


Cys Asp Asp Ile Asn Glu Cys Ala Thr Leu Ser Lys Val Ser Cys Gly 
65                  70                  75                  80  


Lys Phe Ser Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys 
                85                  90                  95      


Ser Pro Gly Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu 
            100                 105                 110         


Ser Glu Asn Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg 
        115                 120                 125             


Leu Cys Lys Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr 
    130                 135                 140                 


Cys Gln Cys Leu Pro Gly Phe Lys Leu Lys Pro Glu Asp Pro Lys Leu 
145                 150                 155                 160 


Cys Thr Asp Val Asn Glu Cys Thr Ser Gly Gln Asn Pro Cys His Ser 
                165                 170                 175     


Ser Thr His Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg 
            180                 185                 190         


Pro Gly Trp Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Thr 
        195                 200                 205             


Val Cys Glu Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp 
    210                 215                 220                 


Ser Ser Thr Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys 
225                 230                 235                 240 


Arg Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp 
                245                 250                 255     


Thr Val Cys Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly 
            260                 265                 270         


Val His Ser Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu 
        275                 280                 285             


Gly Arg Asp Tyr Lys Pro Gly Leu Ala Asn Asn Thr Ile Gln Ser Ile 
    290                 295                 300                 


Leu Gln Ala Leu Asp Glu Leu Leu Glu Ala Pro Gly Asp Leu Glu Thr 
305                 310                 315                 320 


Leu Pro Arg Leu Gln Gln His Cys Val Ala Ser His Leu Leu Asp Gly 
                325                 330                 335     


Leu Glu Asp Val Leu Arg Gly Leu Ser Lys Asn Leu Ser Asn Gly Leu 
            340                 345                 350         


Leu Asn Phe Ser Tyr Pro Ala Gly Thr Glu Leu Ser Leu Glu Val Gln 
        355                 360                 365             


Lys Gln Val Asp Arg Ser Val Thr Leu Arg Gln Asn Gln Ala Val Met 
    370                 375                 380                 


Gln Leu Asp Trp Asn Gln Ala Gln Lys Ser Gly Asp Pro Gly Pro Ser 
385                 390                 395                 400 


Val Val Gly Leu Val Ser Ile Pro Gly Met Gly Lys Leu Leu Ala Glu 
                405                 410                 415     


Ala Pro Leu Val Leu Glu Pro Glu Lys Gln Met Leu Leu His Glu Thr 
            420                 425                 430         


His Gln Gly Leu Leu Gln Asp Gly Ser Pro Ile Leu Leu Ser Asp Val 
        435                 440                 445             


Ile Ser Ala Phe Leu Ser Asn Asn Asp Thr Gln Asn Leu Ser Ser Pro 
    450                 455                 460                 


Val Thr Phe Thr Phe Ser His Arg Glu Glu Asp Pro Val Leu Thr Val 
465                 470                 475                 480 


Ile Thr Tyr Met Gly Leu Ser Val Ser Leu Leu Cys Leu Leu Leu Ala 
                485                 490                 495     


Ala Leu Thr Phe Leu Leu Cys Lys Ala Ile Gln Asn Thr Ser Thr Ser 
            500                 505                 510         


Leu His Leu Gln Leu Ser Leu Cys Leu Phe Leu Ala His Leu Leu Phe 
        515                 520                 525             


Leu Val Ala Ile Asp Gln Thr Gly His Lys Val Leu Cys Ser Ile Ile 
    530                 535                 540                 


Ala Gly Thr Leu His Tyr Leu Tyr Leu Ala Thr Leu Thr Trp Met Leu 
545                 550                 555                 560 


Leu Glu Ala Leu Tyr Leu Phe Leu Thr Ala Arg Asn Leu Thr Val Val 
                565                 570                 575     


Asn Tyr Ser Ser Ile Asn Arg Phe Met Lys Lys Leu Met Phe Pro Val 
            580                 585                 590         


Gly Tyr Gly Val Pro Ala Val Thr Val Ala Ile Ser Ala Ala Ser Arg 
        595                 600                 605             


Pro His Leu Tyr Gly Thr Pro Ser Arg Cys Trp Leu Gln Pro Glu Lys 
    610                 615                 620                 


Gly Phe Ile Trp Gly Phe Leu Gly Pro Val Cys Ala Ile Phe Ser Val 
625                 630                 635                 640 


Asn Leu Val Leu Phe Leu Val Thr Leu Trp Ile Leu Lys Asn Arg Leu 
                645                 650                 655     


Ser Ser Leu Asn Ser Glu Val Ser Thr Leu Arg Asn Thr Arg Met Leu 
            660                 665                 670         


Ala Phe Lys Ala Thr Ala Gln Leu Phe Ile Leu Gly Cys Thr Trp Cys 
        675                 680                 685             


Leu Gly Ile Leu Gln Val Gly Pro Ala Ala Arg Val Met Ala Tyr Leu 
    690                 695                 700                 


Phe Thr Ile Ile Asn Ser Leu Gln Gly Val Phe Ile Phe Leu Val Tyr 
705                 710                 715                 720 


Cys Leu Leu Ser Gln Gln Val Arg Glu Gln Tyr Gly Lys Trp Ser Lys 
                725                 730                 735     


Gly Ile Arg Lys Leu Lys Thr Glu Ser Glu Met His Thr Leu Ser Ser 
            740                 745                 750         


Ser Ala Lys Ala Asp Thr Ser Lys Pro Ser Thr Val Asn 
        755                 760                 765 


<210>  6135
<211>  765
<212>  PRT
<213>  Homo sapiens

<400>  6135

Met Gly Gly Arg Val Phe Leu Val Phe Leu Ala Phe Cys Val Trp Leu 
1               5                   10                  15      


Thr Leu Pro Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp 
            20                  25                  30          


Cys Pro Gln Asp Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn 
        35                  40                  45              


Pro Gly Phe Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Met Glu Thr 
    50                  55                  60                  


Cys Asp Asp Ile Asn Glu Cys Ala Thr Leu Ser Lys Val Ser Cys Gly 
65                  70                  75                  80  


Lys Phe Ser Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys 
                85                  90                  95      


Ser Pro Gly Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu 
            100                 105                 110         


Ser Glu Asn Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg 
        115                 120                 125             


Leu Cys Lys Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr 
    130                 135                 140                 


Cys Gln Cys Leu Pro Gly Phe Lys Leu Lys Pro Glu Asp Pro Lys Leu 
145                 150                 155                 160 


Cys Thr Asp Val Asn Glu Cys Thr Ser Gly Gln Asn Pro Cys His Ser 
                165                 170                 175     


Ser Thr His Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg 
            180                 185                 190         


Pro Gly Trp Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Thr 
        195                 200                 205             


Val Cys Glu Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp 
    210                 215                 220                 


Ser Ser Thr Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys 
225                 230                 235                 240 


Arg Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp 
                245                 250                 255     


Thr Val Cys Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly 
            260                 265                 270         


Val His Ser Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu 
        275                 280                 285             


Gly Arg Asp Tyr Lys Pro Gly Leu Ala Asn Asn Thr Ile Gln Ser Ile 
    290                 295                 300                 


Leu Gln Ala Leu Asp Glu Leu Leu Glu Ala Pro Gly Asp Leu Glu Thr 
305                 310                 315                 320 


Leu Pro Arg Leu Gln Gln His Cys Val Ala Ser His Leu Leu Asp Gly 
                325                 330                 335     


Leu Glu Asp Val Leu Arg Gly Leu Ser Lys Asn Leu Ser Asn Gly Leu 
            340                 345                 350         


Leu Asn Phe Ser Tyr Pro Ala Gly Thr Glu Leu Ser Leu Glu Val Gln 
        355                 360                 365             


Lys Gln Val Asp Arg Ser Val Thr Leu Arg Gln Asn Gln Ala Val Met 
    370                 375                 380                 


Gln Leu Asp Trp Asn Gln Ala Gln Lys Ser Gly Asp Pro Gly Pro Ser 
385                 390                 395                 400 


Val Val Gly Leu Val Ser Ile Pro Gly Met Gly Lys Leu Leu Ala Glu 
                405                 410                 415     


Ala Pro Leu Val Leu Glu Pro Glu Lys Gln Met Leu Leu His Glu Thr 
            420                 425                 430         


His Gln Gly Leu Leu Gln Asp Gly Ser Pro Ile Leu Leu Ser Asp Val 
        435                 440                 445             


Ile Ser Ala Phe Leu Ser Asn Asn Asp Thr Gln Asn Leu Ser Ser Pro 
    450                 455                 460                 


Val Thr Phe Thr Phe Ser His Arg Glu Glu Asp Pro Val Leu Thr Val 
465                 470                 475                 480 


Ile Thr Tyr Met Gly Leu Ser Val Ser Leu Leu Cys Leu Leu Leu Ala 
                485                 490                 495     


Ala Leu Thr Phe Leu Leu Cys Lys Ala Ile Gln Asn Thr Ser Thr Ser 
            500                 505                 510         


Leu His Leu Gln Leu Ser Leu Cys Leu Phe Leu Ala His Leu Leu Phe 
        515                 520                 525             


Leu Val Ala Ile Asp Gln Thr Gly His Lys Val Leu Cys Ser Ile Ile 
    530                 535                 540                 


Ala Gly Thr Leu His Tyr Leu Tyr Leu Ala Thr Leu Thr Trp Met Leu 
545                 550                 555                 560 


Leu Glu Ala Leu Tyr Leu Phe Leu Thr Ala Arg Asn Leu Thr Val Val 
                565                 570                 575     


Asn Tyr Ser Ser Ile Asn Arg Phe Met Lys Lys Leu Met Phe Pro Val 
            580                 585                 590         


Gly Tyr Gly Val Pro Ala Val Thr Val Ala Ile Ser Ala Ala Ser Arg 
        595                 600                 605             


Pro His Leu Tyr Gly Thr Pro Ser Arg Cys Trp Leu Gln Pro Glu Lys 
    610                 615                 620                 


Gly Phe Ile Trp Gly Phe Leu Gly Pro Val Cys Ala Ile Phe Ser Val 
625                 630                 635                 640 


Asn Leu Val Leu Phe Leu Val Thr Leu Trp Ile Leu Lys Asn Arg Leu 
                645                 650                 655     


Ser Ser Leu Asn Ser Glu Val Ser Thr Leu Arg Asn Thr Arg Met Leu 
            660                 665                 670         


Ala Phe Lys Ala Thr Ala Gln Leu Phe Ile Leu Gly Cys Thr Trp Cys 
        675                 680                 685             


Leu Gly Ile Leu Gln Val Gly Pro Ala Ala Arg Val Met Ala Tyr Leu 
    690                 695                 700                 


Phe Thr Ile Ile Asn Ser Leu Gln Gly Val Phe Ile Phe Leu Val Tyr 
705                 710                 715                 720 


Cys Leu Leu Ser Gln Gln Val Arg Glu Gln Tyr Gly Lys Trp Ser Lys 
                725                 730                 735     


Gly Ile Arg Lys Leu Lys Thr Glu Ser Glu Met His Thr Leu Ser Ser 
            740                 745                 750         


Ser Ala Lys Ala Asp Thr Ser Lys Pro Ser Thr Val Asn 
        755                 760                 765 


<210>  6136
<211>  765
<212>  PRT
<213>  Homo sapiens

<400>  6136

Met Gly Gly Arg Val Phe Leu Val Phe Leu Ala Phe Cys Val Trp Leu 
1               5                   10                  15      


Thr Leu Pro Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp 
            20                  25                  30          


Cys Pro Gln Asp Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn 
        35                  40                  45              


Pro Gly Phe Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Met Glu Thr 
    50                  55                  60                  


Cys Asp Asp Ile Asn Glu Cys Ala Thr Leu Ser Lys Val Ser Cys Gly 
65                  70                  75                  80  


Lys Phe Ser Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys 
                85                  90                  95      


Ser Pro Gly Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu 
            100                 105                 110         


Ser Glu Asn Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg 
        115                 120                 125             


Leu Cys Lys Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr 
    130                 135                 140                 


Cys Gln Cys Leu Pro Gly Phe Lys Leu Lys Pro Glu Asp Pro Lys Leu 
145                 150                 155                 160 


Cys Thr Asp Val Asn Glu Cys Thr Ser Gly Gln Asn Pro Cys His Ser 
                165                 170                 175     


Ser Thr His Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg 
            180                 185                 190         


Pro Gly Trp Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Thr 
        195                 200                 205             


Val Cys Glu Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp 
    210                 215                 220                 


Ser Ser Thr Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys 
225                 230                 235                 240 


Arg Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp 
                245                 250                 255     


Thr Val Cys Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly 
            260                 265                 270         


Val His Ser Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu 
        275                 280                 285             


Gly Arg Asp Tyr Lys Pro Gly Leu Ala Asn Asn Thr Ile Gln Ser Ile 
    290                 295                 300                 


Leu Gln Ala Leu Asp Glu Leu Leu Glu Ala Pro Gly Asp Leu Glu Thr 
305                 310                 315                 320 


Leu Pro Arg Leu Gln Gln His Cys Val Ala Ser His Leu Leu Asp Gly 
                325                 330                 335     


Leu Glu Asp Val Leu Arg Gly Leu Ser Lys Asn Leu Ser Asn Gly Leu 
            340                 345                 350         


Leu Asn Phe Ser Tyr Pro Ala Gly Thr Glu Leu Ser Leu Glu Val Gln 
        355                 360                 365             


Lys Gln Val Asp Arg Ser Val Thr Leu Arg Gln Asn Gln Ala Val Met 
    370                 375                 380                 


Gln Leu Asp Trp Asn Gln Ala Gln Lys Ser Gly Asp Pro Gly Pro Ser 
385                 390                 395                 400 


Val Val Gly Leu Val Ser Ile Pro Gly Met Gly Lys Leu Leu Ala Glu 
                405                 410                 415     


Ala Pro Leu Val Leu Glu Pro Glu Lys Gln Met Leu Leu His Glu Thr 
            420                 425                 430         


His Gln Gly Leu Leu Gln Asp Gly Ser Pro Ile Leu Leu Ser Asp Val 
        435                 440                 445             


Ile Ser Ala Phe Leu Ser Asn Asn Asp Thr Gln Asn Leu Ser Ser Pro 
    450                 455                 460                 


Val Thr Phe Thr Phe Ser His Arg Glu Glu Asp Pro Val Leu Thr Val 
465                 470                 475                 480 


Ile Thr Tyr Met Gly Leu Ser Val Ser Leu Leu Cys Leu Leu Leu Ala 
                485                 490                 495     


Ala Leu Thr Phe Leu Leu Cys Lys Ala Ile Gln Asn Thr Ser Thr Ser 
            500                 505                 510         


Leu His Leu Gln Leu Ser Leu Cys Leu Phe Leu Ala His Leu Leu Phe 
        515                 520                 525             


Leu Val Ala Ile Asp Gln Thr Gly His Lys Val Leu Cys Ser Ile Ile 
    530                 535                 540                 


Ala Gly Thr Leu His Tyr Leu Tyr Leu Ala Thr Leu Thr Trp Met Leu 
545                 550                 555                 560 


Leu Glu Ala Leu Tyr Leu Phe Leu Thr Ala Arg Asn Leu Thr Val Val 
                565                 570                 575     


Asn Tyr Ser Ser Ile Asn Arg Phe Met Lys Lys Leu Met Phe Pro Val 
            580                 585                 590         


Gly Tyr Gly Val Pro Ala Val Thr Val Ala Ile Ser Ala Ala Ser Arg 
        595                 600                 605             


Pro His Leu Tyr Gly Thr Pro Ser Arg Cys Trp Leu Gln Pro Glu Lys 
    610                 615                 620                 


Gly Phe Ile Trp Gly Phe Leu Gly Pro Val Cys Ala Ile Phe Ser Val 
625                 630                 635                 640 


Asn Leu Val Leu Phe Leu Val Thr Leu Trp Ile Leu Lys Asn Arg Leu 
                645                 650                 655     


Ser Ser Leu Asn Ser Glu Val Ser Thr Leu Arg Asn Thr Arg Met Leu 
            660                 665                 670         


Ala Phe Lys Ala Thr Ala Gln Leu Phe Ile Leu Gly Cys Thr Trp Cys 
        675                 680                 685             


Leu Gly Ile Leu Gln Val Gly Pro Ala Ala Arg Val Met Ala Tyr Leu 
    690                 695                 700                 


Phe Thr Ile Ile Asn Ser Leu Gln Gly Val Phe Ile Phe Leu Val Tyr 
705                 710                 715                 720 


Cys Leu Leu Ser Gln Gln Val Arg Glu Gln Tyr Gly Lys Trp Ser Lys 
                725                 730                 735     


Gly Ile Arg Lys Leu Lys Thr Glu Ser Glu Met His Thr Leu Ser Ser 
            740                 745                 750         


Ser Ala Lys Ala Asp Thr Ser Lys Pro Ser Thr Val Asn 
        755                 760                 765 


<210>  6137
<211>  765
<212>  PRT
<213>  Homo sapiens

<400>  6137

Met Gly Gly Arg Val Phe Leu Val Phe Leu Ala Phe Cys Val Trp Leu 
1               5                   10                  15      


Thr Leu Pro Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp 
            20                  25                  30          


Cys Pro Gln Asp Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn 
        35                  40                  45              


Pro Gly Phe Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Met Glu Thr 
    50                  55                  60                  


Cys Asp Asp Ile Asn Glu Cys Ala Thr Leu Ser Lys Val Ser Cys Gly 
65                  70                  75                  80  


Lys Phe Ser Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys 
                85                  90                  95      


Ser Pro Gly Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu 
            100                 105                 110         


Ser Glu Asn Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg 
        115                 120                 125             


Leu Cys Lys Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr 
    130                 135                 140                 


Cys Gln Cys Leu Pro Gly Phe Lys Leu Lys Pro Glu Asp Pro Lys Leu 
145                 150                 155                 160 


Cys Thr Asp Val Asn Glu Cys Thr Ser Gly Gln Asn Pro Cys His Ser 
                165                 170                 175     


Ser Thr His Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg 
            180                 185                 190         


Pro Gly Trp Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Thr 
        195                 200                 205             


Val Cys Glu Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp 
    210                 215                 220                 


Ser Ser Thr Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys 
225                 230                 235                 240 


Arg Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp 
                245                 250                 255     


Thr Val Cys Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly 
            260                 265                 270         


Val His Ser Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu 
        275                 280                 285             


Gly Arg Asp Tyr Lys Pro Gly Leu Ala Asn Asn Thr Ile Gln Ser Ile 
    290                 295                 300                 


Leu Gln Ala Leu Asp Glu Leu Leu Glu Ala Pro Gly Asp Leu Glu Thr 
305                 310                 315                 320 


Leu Pro Arg Leu Gln Gln His Cys Val Ala Ser His Leu Leu Asp Gly 
                325                 330                 335     


Leu Glu Asp Val Leu Arg Gly Leu Ser Lys Asn Leu Ser Asn Gly Leu 
            340                 345                 350         


Leu Asn Phe Ser Tyr Pro Ala Gly Thr Glu Leu Ser Leu Glu Val Gln 
        355                 360                 365             


Lys Gln Val Asp Arg Ser Val Thr Leu Arg Gln Asn Gln Ala Val Met 
    370                 375                 380                 


Gln Leu Asp Trp Asn Gln Ala Gln Lys Ser Gly Asp Pro Gly Pro Ser 
385                 390                 395                 400 


Val Val Gly Leu Val Ser Ile Pro Gly Met Gly Lys Leu Leu Ala Glu 
                405                 410                 415     


Ala Pro Leu Val Leu Glu Pro Glu Lys Gln Met Leu Leu His Glu Thr 
            420                 425                 430         


His Gln Gly Leu Leu Gln Asp Gly Ser Pro Ile Leu Leu Ser Asp Val 
        435                 440                 445             


Ile Ser Ala Phe Leu Ser Asn Asn Asp Thr Gln Asn Leu Ser Ser Pro 
    450                 455                 460                 


Val Thr Phe Thr Phe Ser His Arg Glu Glu Asp Pro Val Leu Thr Val 
465                 470                 475                 480 


Ile Thr Tyr Met Gly Leu Ser Val Ser Leu Leu Cys Leu Leu Leu Ala 
                485                 490                 495     


Ala Leu Thr Phe Leu Leu Cys Lys Ala Ile Gln Asn Thr Ser Thr Ser 
            500                 505                 510         


Leu His Leu Gln Leu Ser Leu Cys Leu Phe Leu Ala His Leu Leu Phe 
        515                 520                 525             


Leu Val Ala Ile Asp Gln Thr Gly His Lys Val Leu Cys Ser Ile Ile 
    530                 535                 540                 


Ala Gly Thr Leu His Tyr Leu Tyr Leu Ala Thr Leu Thr Trp Met Leu 
545                 550                 555                 560 


Leu Glu Ala Leu Tyr Leu Phe Leu Thr Ala Arg Asn Leu Thr Val Val 
                565                 570                 575     


Asn Tyr Ser Ser Ile Asn Arg Phe Met Lys Lys Leu Met Phe Pro Val 
            580                 585                 590         


Gly Tyr Gly Val Pro Ala Val Thr Val Ala Ile Ser Ala Ala Ser Arg 
        595                 600                 605             


Pro His Leu Tyr Gly Thr Pro Ser Arg Cys Trp Leu Gln Pro Glu Lys 
    610                 615                 620                 


Gly Phe Ile Trp Gly Phe Leu Gly Pro Val Cys Ala Ile Phe Ser Val 
625                 630                 635                 640 


Asn Leu Val Leu Phe Leu Val Thr Leu Trp Ile Leu Lys Asn Arg Leu 
                645                 650                 655     


Ser Ser Leu Asn Ser Glu Val Ser Thr Leu Arg Asn Thr Arg Met Leu 
            660                 665                 670         


Ala Phe Lys Ala Thr Ala Gln Leu Phe Ile Leu Gly Cys Thr Trp Cys 
        675                 680                 685             


Leu Gly Ile Leu Gln Val Gly Pro Ala Ala Arg Val Met Ala Tyr Leu 
    690                 695                 700                 


Phe Thr Ile Ile Asn Ser Leu Gln Gly Val Phe Ile Phe Leu Val Tyr 
705                 710                 715                 720 


Cys Leu Leu Ser Gln Gln Val Arg Glu Gln Tyr Gly Lys Trp Ser Lys 
                725                 730                 735     


Gly Ile Arg Lys Leu Lys Thr Glu Ser Glu Met His Thr Leu Ser Ser 
            740                 745                 750         


Ser Ala Lys Ala Asp Thr Ser Lys Pro Ser Thr Val Asn 
        755                 760                 765 


<210>  6138
<211>  765
<212>  PRT
<213>  Homo sapiens

<400>  6138

Met Gly Gly Arg Val Phe Leu Val Phe Leu Ala Phe Cys Val Trp Leu 
1               5                   10                  15      


Thr Leu Pro Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp 
            20                  25                  30          


Cys Pro Gln Asp Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn 
        35                  40                  45              


Pro Gly Phe Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Met Glu Thr 
    50                  55                  60                  


Cys Asp Asp Ile Asn Glu Cys Ala Thr Leu Ser Lys Val Ser Cys Gly 
65                  70                  75                  80  


Lys Phe Ser Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys 
                85                  90                  95      


Ser Pro Gly Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu 
            100                 105                 110         


Ser Glu Asn Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg 
        115                 120                 125             


Leu Cys Lys Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr 
    130                 135                 140                 


Cys Gln Cys Leu Pro Gly Phe Lys Leu Lys Pro Glu Asp Pro Lys Leu 
145                 150                 155                 160 


Cys Thr Asp Val Asn Glu Cys Thr Ser Gly Gln Asn Pro Cys His Ser 
                165                 170                 175     


Ser Thr His Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg 
            180                 185                 190         


Pro Gly Trp Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Thr 
        195                 200                 205             


Val Cys Glu Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp 
    210                 215                 220                 


Ser Ser Thr Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys 
225                 230                 235                 240 


Arg Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp 
                245                 250                 255     


Thr Val Cys Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly 
            260                 265                 270         


Val His Ser Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu 
        275                 280                 285             


Gly Arg Asp Tyr Lys Pro Gly Leu Ala Asn Asn Thr Ile Gln Ser Ile 
    290                 295                 300                 


Leu Gln Ala Leu Asp Glu Leu Leu Glu Ala Pro Gly Asp Leu Glu Thr 
305                 310                 315                 320 


Leu Pro Arg Leu Gln Gln His Cys Val Ala Ser His Leu Leu Asp Gly 
                325                 330                 335     


Leu Glu Asp Val Leu Arg Gly Leu Ser Lys Asn Leu Ser Asn Gly Leu 
            340                 345                 350         


Leu Asn Phe Ser Tyr Pro Ala Gly Thr Glu Leu Ser Leu Glu Val Gln 
        355                 360                 365             


Lys Gln Val Asp Arg Ser Val Thr Leu Arg Gln Asn Gln Ala Val Met 
    370                 375                 380                 


Gln Leu Asp Trp Asn Gln Ala Gln Lys Ser Gly Asp Pro Gly Pro Ser 
385                 390                 395                 400 


Val Val Gly Leu Val Ser Ile Pro Gly Met Gly Lys Leu Leu Ala Glu 
                405                 410                 415     


Ala Pro Leu Val Leu Glu Pro Glu Lys Gln Met Leu Leu His Glu Thr 
            420                 425                 430         


His Gln Gly Leu Leu Gln Asp Gly Ser Pro Ile Leu Leu Ser Asp Val 
        435                 440                 445             


Ile Ser Ala Phe Leu Ser Asn Asn Asp Thr Gln Asn Leu Ser Ser Pro 
    450                 455                 460                 


Val Thr Phe Thr Phe Ser His Arg Glu Glu Asp Pro Val Leu Thr Val 
465                 470                 475                 480 


Ile Thr Tyr Met Gly Leu Ser Val Ser Leu Leu Cys Leu Leu Leu Ala 
                485                 490                 495     


Ala Leu Thr Phe Leu Leu Cys Lys Ala Ile Gln Asn Thr Ser Thr Ser 
            500                 505                 510         


Leu His Leu Gln Leu Ser Leu Cys Leu Phe Leu Ala His Leu Leu Phe 
        515                 520                 525             


Leu Val Ala Ile Asp Gln Thr Gly His Lys Val Leu Cys Ser Ile Ile 
    530                 535                 540                 


Ala Gly Thr Leu His Tyr Leu Tyr Leu Ala Thr Leu Thr Trp Met Leu 
545                 550                 555                 560 


Leu Glu Ala Leu Tyr Leu Phe Leu Thr Ala Arg Asn Leu Thr Val Val 
                565                 570                 575     


Asn Tyr Ser Ser Ile Asn Arg Phe Met Lys Lys Leu Met Phe Pro Val 
            580                 585                 590         


Gly Tyr Gly Val Pro Ala Val Thr Val Ala Ile Ser Ala Ala Ser Arg 
        595                 600                 605             


Pro His Leu Tyr Gly Thr Pro Ser Arg Cys Trp Leu Gln Pro Glu Lys 
    610                 615                 620                 


Gly Phe Ile Trp Gly Phe Leu Gly Pro Val Cys Ala Ile Phe Ser Val 
625                 630                 635                 640 


Asn Leu Val Leu Phe Leu Val Thr Leu Trp Ile Leu Lys Asn Arg Leu 
                645                 650                 655     


Ser Ser Leu Asn Ser Glu Val Ser Thr Leu Arg Asn Thr Arg Met Leu 
            660                 665                 670         


Ala Phe Lys Ala Thr Ala Gln Leu Phe Ile Leu Gly Cys Thr Trp Cys 
        675                 680                 685             


Leu Gly Ile Leu Gln Val Gly Pro Ala Ala Arg Val Met Ala Tyr Leu 
    690                 695                 700                 


Phe Thr Ile Ile Asn Ser Leu Gln Gly Val Phe Ile Phe Leu Val Tyr 
705                 710                 715                 720 


Cys Leu Leu Ser Gln Gln Val Arg Glu Gln Tyr Gly Lys Trp Ser Lys 
                725                 730                 735     


Gly Ile Arg Lys Leu Lys Thr Glu Ser Glu Met His Thr Leu Ser Ser 
            740                 745                 750         


Ser Ala Lys Ala Asp Thr Ser Lys Pro Ser Thr Val Asn 
        755                 760                 765 


<210>  6139
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  6139

Met Ser Phe Arg Lys Val Asn Ile Ile Ile Leu Val Leu Ala Val Ala 
1               5                   10                  15      


Leu Phe Leu Leu Val Leu His His Asn Phe Leu Ser Leu Ser Ser Leu 
            20                  25                  30          


Leu Arg Asn Glu Val Thr Asp Ser Gly Ile Val Gly Pro Gln Pro Ile 
        35                  40                  45              


Asp Phe Val Pro Asn Ala Leu Arg His Ala Val Asp Gly Arg Gln Glu 
    50                  55                  60                  


Glu Ile Pro Val Val Ile Ala Ala Ser Glu Asp Arg Leu Gly Gly Ala 
65                  70                  75                  80  


Ile Ala Ala Ile Asn Ser Ile Gln His Asn Thr Arg Ser Asn Val Ile 
                85                  90                  95      


Phe Tyr Ile Val Thr Leu Asn Asn Thr Ala Asp His Leu Arg Ser Trp 
            100                 105                 110         


Leu Asn Ser Asp Ser Leu Lys Ser Ile Arg Tyr Lys Ile Val Asn Phe 
        115                 120                 125             


Asp Pro Lys Leu Leu Glu Gly Lys Val Lys Glu Asp Pro Asp Gln Gly 
    130                 135                 140                 


Glu Ser Met Lys Pro Leu Thr Phe Ala Arg Phe Tyr Leu Pro Ile Leu 
145                 150                 155                 160 


Val Pro Ser Ala Lys Lys Ala Ile Tyr Met Asp Asp Asp Val Ile Val 
                165                 170                 175     


Gln Gly Asp Ile Leu Ala Leu Tyr Asn Thr Ala Leu Lys Pro Gly His 
            180                 185                 190         


Ala Ala Ala Phe Ser Glu Asp Cys Asp Ser Ala Ser Thr Lys Val Val 
        195                 200                 205             


Ile Arg Gly Ala Gly Asn Gln Tyr Asn Tyr Ile Gly Tyr Leu Asp Tyr 
    210                 215                 220                 


Lys Lys Glu Arg Ile Arg Lys Leu Ser Met Lys Ala Ser Thr Cys Ser 
225                 230                 235                 240 


Phe Asn Pro Gly Val Phe Val Ala Asn Leu Thr Glu Trp Lys Arg Gln 
                245                 250                 255     


Asn Ile Thr Asn Gln Leu Glu Lys Trp Met Lys Leu Asn Val Glu Glu 
            260                 265                 270         


Gly Leu Tyr Ser Arg Thr Leu Ala Gly Ser Ile Thr Thr Pro Pro Leu 
        275                 280                 285             


Leu Ile Val Phe Tyr Gln Gln His Ser Thr Ile Asp Pro Met Trp Asn 
    290                 295                 300                 


Val Arg His Leu Gly Ser Ser Ala Gly Lys Arg Tyr Ser Pro Gln Phe 
305                 310                 315                 320 


Val Lys Ala Ala Lys Leu Leu His Trp Asn Gly His Leu Lys Pro Trp 
                325                 330                 335     


Gly Arg Thr Ala Ser Tyr Thr Asp Val Trp Glu Lys Trp Tyr Ile Pro 
            340                 345                 350         


Asp Pro Thr Gly Lys Phe Asn Leu Ile Arg Arg Tyr Thr Glu Ile Ser 
        355                 360                 365             


Asn Ile Lys 
    370     


<210>  6140
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  6140

Met Arg Val Leu Leu Ala Ala Leu Gly Leu Leu Phe Leu Gly Ala Leu 
1               5                   10                  15      


Arg Ala Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn 
            20                  25                  30          


Pro Ser His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys 
        35                  40                  45              


Pro Met Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp 
    50                  55                  60                  


Cys Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg 
65                  70                  75                  80  


Cys Thr Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr 
                85                  90                  95      


Pro Cys Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met 
            100                 105                 110         


Phe Cys Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His 
        115                 120                 125             


Ser Val Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln 
    130                 135                 140                 


Lys Asn Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys 
145                 150                 155                 160 


Ala Ser Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln 
                165                 170                 175     


Ala Lys Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met 
            180                 185                 190         


Pro Val Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu 
        195                 200                 205             


Thr Arg Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp 
    210                 215                 220                 


Pro Gly Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys 
225                 230                 235                 240 


Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys 
                245                 250                 255     


Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro 
            260                 265                 270         


Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile 
        275                 280                 285             


Cys Ala Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro 
    290                 295                 300                 


Ile Cys Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys 
305                 310                 315                 320 


Asp Thr Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn 
                325                 330                 335     


Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln 
            340                 345                 350         


Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr 
        355                 360                 365             


Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala 
    370                 375                 380                 


Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly 
385                 390                 395                 400 


Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile 
                405                 410                 415     


Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys 
            420                 425                 430         


Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg 
        435                 440                 445             


Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met 
    450                 455                 460                 


Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu 
465                 470                 475                 480 


Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser 
                485                 490                 495     


Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn 
            500                 505                 510         


Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly 
        515                 520                 525             


Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala 
    530                 535                 540                 


Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr 
545                 550                 555                 560 


Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met 
                565                 570                 575     


Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala 
            580                 585                 590         


Ser Gly Lys 
        595 


<210>  6141
<211>  592
<212>  PRT
<213>  Homo sapiens

<400>  6141

Met Ala Ala Ala Val Ala Ala Ala Leu Ala Arg Leu Leu Ala Ala Phe 
1               5                   10                  15      


Leu Leu Leu Ala Ala Gln Val Ala Cys Glu Tyr Gly Met Val His Val 
            20                  25                  30          


Val Ser Gln Ala Gly Gly Pro Glu Gly Lys Asp Tyr Cys Ile Leu Tyr 
        35                  40                  45              


Asn Pro Gln Trp Ala His Leu Pro His Asp Leu Ser Lys Ala Ser Phe 
    50                  55                  60                  


Leu Gln Leu Arg Asn Trp Thr Ala Ser Leu Leu Cys Ser Ala Ala Asp 
65                  70                  75                  80  


Leu Pro Ala Arg Gly Phe Ser Asn Gln Ile Pro Leu Val Ala Arg Gly 
                85                  90                  95      


Asn Cys Thr Phe Tyr Glu Lys Val Arg Leu Ala Gln Gly Ser Gly Ala 
            100                 105                 110         


Arg Gly Leu Leu Ile Val Ser Arg Glu Arg Leu Val Pro Pro Gly Gly 
        115                 120                 125             


Asn Lys Thr Gln Tyr Asp Glu Ile Gly Ile Pro Val Ala Leu Leu Ser 
    130                 135                 140                 


Tyr Lys Asp Met Leu Asp Ile Phe Thr Arg Phe Gly Arg Thr Val Arg 
145                 150                 155                 160 


Ala Ala Leu Tyr Ala Pro Lys Glu Pro Val Leu Asp Tyr Asn Met Val 
                165                 170                 175     


Ile Ile Phe Ile Met Ala Val Gly Thr Val Ala Ile Gly Gly Tyr Trp 
            180                 185                 190         


Ala Gly Ser Arg Asp Val Lys Lys Arg Tyr Met Lys His Lys Arg Asp 
        195                 200                 205             


Asp Gly Pro Glu Lys Gln Glu Asp Glu Ala Val Asp Val Thr Pro Val 
    210                 215                 220                 


Met Thr Cys Val Phe Val Val Met Cys Cys Ser Met Leu Val Leu Leu 
225                 230                 235                 240 


Tyr Tyr Phe Tyr Asp Leu Leu Val Tyr Val Val Ile Gly Ile Phe Cys 
                245                 250                 255     


Leu Ala Ser Ala Thr Gly Leu Tyr Ser Cys Leu Ala Pro Cys Val Arg 
            260                 265                 270         


Arg Leu Pro Phe Gly Lys Cys Arg Ile Pro Asn Asn Ser Leu Pro Tyr 
        275                 280                 285             


Phe His Lys Arg Pro Gln Ala Arg Met Leu Leu Leu Ala Leu Phe Cys 
    290                 295                 300                 


Val Ala Val Ser Val Val Trp Gly Val Phe Arg Asn Glu Asp Gln Trp 
305                 310                 315                 320 


Ala Trp Val Leu Gln Asp Ala Leu Gly Ile Ala Phe Cys Leu Tyr Met 
                325                 330                 335     


Leu Lys Thr Ile Arg Leu Pro Thr Phe Lys Ala Cys Thr Leu Leu Leu 
            340                 345                 350         


Leu Val Leu Phe Leu Tyr Asp Ile Phe Phe Val Phe Ile Thr Pro Phe 
        355                 360                 365             


Leu Thr Lys Ser Gly Ser Ser Ile Met Val Glu Val Ala Thr Gly Pro 
    370                 375                 380                 


Ser Asp Ser Ala Thr Arg Glu Lys Leu Pro Met Val Leu Lys Val Pro 
385                 390                 395                 400 


Arg Leu Asn Ser Ser Pro Leu Ala Leu Cys Asp Arg Pro Phe Ser Leu 
                405                 410                 415     


Leu Gly Phe Gly Asp Ile Leu Val Pro Gly Leu Leu Val Ala Tyr Cys 
            420                 425                 430         


His Arg Phe Asp Ile Gln Val Gln Ser Ser Arg Val Tyr Phe Val Ala 
        435                 440                 445             


Cys Thr Ile Ala Tyr Gly Val Gly Leu Leu Val Thr Phe Val Ala Leu 
    450                 455                 460                 


Ala Leu Met Gln Arg Gly Gln Pro Ala Leu Leu Tyr Leu Val Pro Cys 
465                 470                 475                 480 


Thr Leu Val Thr Ser Cys Ala Val Ala Leu Trp Arg Arg Glu Leu Gly 
                485                 490                 495     


Val Phe Trp Thr Gly Ser Gly Phe Ala Lys Val Leu Pro Pro Ser Pro 
            500                 505                 510         


Trp Ala Pro Ala Pro Ala Asp Gly Pro Gln Pro Pro Lys Asp Ser Ala 
        515                 520                 525             


Thr Pro Leu Ser Pro Gln Pro Pro Ser Glu Glu Pro Ala Thr Ser Pro 
    530                 535                 540                 


Trp Pro Ala Glu Gln Ser Pro Lys Ser Arg Thr Ser Glu Glu Met Gly 
545                 550                 555                 560 


Ala Gly Ala Pro Met Arg Glu Pro Gly Ser Pro Ala Glu Ser Glu Gly 
                565                 570                 575     


Arg Asp Gln Ala Gln Pro Ser Pro Val Thr Gln Pro Gly Ala Ser Ala 
            580                 585                 590         


<210>  6142
<211>  911
<212>  PRT
<213>  Homo sapiens

<400>  6142

Met Glu Ala Ser Trp Arg Gln Val Ala Gly Gly Arg Gly Arg Ser Arg 
1               5                   10                  15      


Gly Arg Ala Thr Ala Ala Pro Ser Gly Asn Gly Val His Leu Arg Gly 
            20                  25                  30          


Ala Gly Gly Gly Arg Glu Lys Gly Ser Val Gly Ala Val Pro Ser Gly 
        35                  40                  45              


Thr Ser Pro Gly Gly Val Ala Thr Thr Ala Ala Ala Gly Ser Arg His 
    50                  55                  60                  


Ser Pro Ala Gly Ser Gln Ala Leu Gln Thr Thr Ala Ala Ser Glu Leu 
65                  70                  75                  80  


Met Ser Gln Lys Lys Phe Glu Glu Ile Lys Lys Ala Asn Gln Ala Ala 
                85                  90                  95      


Ala Arg Lys Leu Val Glu Glu Gln Phe Ser Ser Ser Ser Glu Glu Gly 
            100                 105                 110         


Asp Glu Asp Phe Glu Gly Lys Gln Gly Lys Ile Leu Ala Asn Thr Phe 
        115                 120                 125             


Ile Thr Tyr Thr Thr Gln Thr Asp Gly Asp Thr Arg Glu Leu Glu Arg 
    130                 135                 140                 


Thr Lys Gln Tyr Val Asn Glu Ala Phe Gln Ala Gly Ala Met Thr Cys 
145                 150                 155                 160 


Leu Ile Cys Ile Ala Ser Val Lys Arg Asn Gln Ala Val Trp Ser Cys 
                165                 170                 175     


Ser Gly Cys Phe Cys Ile Phe His Met Pro Cys Ile Gln Lys Trp Ala 
            180                 185                 190         


Lys Asp Ser Gln Phe Leu Val Ser Ser Val Thr Asp Asp Asp Phe Gly 
        195                 200                 205             


Lys Lys Asp Cys Pro Trp Pro Cys Pro Lys Cys Arg Phe Glu Tyr Lys 
    210                 215                 220                 


Arg Ser Glu Thr Pro Ser Arg Tyr Tyr Cys Tyr Cys Gly Lys Val Glu 
225                 230                 235                 240 


Asp Pro Pro Leu Asp Pro Trp Leu Val Pro His Ser Cys Gly Gln Val 
                245                 250                 255     


Cys Glu Arg Glu Phe Lys Pro Pro Cys Gly His Lys Cys Leu Leu Leu 
            260                 265                 270         


Cys His Pro Gly Pro Cys Pro Pro Cys Pro Lys Met Val Thr Thr Thr 
        275                 280                 285             


Cys Tyr Cys Lys Lys Ala Lys Pro Ile Pro Arg Arg Cys Ser Ala Lys 
    290                 295                 300                 


Glu Trp Ser Cys Gln Leu Pro Cys Gly Gln Lys Leu Leu Cys Gly Gln 
305                 310                 315                 320 


His Lys Cys Glu Asn Pro Cys His Ala Gly Ser Cys Gln Pro Cys Pro 
                325                 330                 335     


Arg Val Ser Arg Gln Lys Cys Val Cys Gly Lys Lys Val Ala Glu Arg 
            340                 345                 350         


Ser Cys Ala Ser Pro Leu Trp His Cys Asp Gln Val Cys Gly Lys Thr 
        355                 360                 365             


Leu Pro Cys Gly Asn His Thr Cys Glu Gln Val Cys His Val Gly Ala 
    370                 375                 380                 


Cys Gly Glu Cys Pro Arg Ser Gly Lys Arg Phe Cys Pro Cys Gln Lys 
385                 390                 395                 400 


Ser Lys Phe Ser Leu Pro Cys Thr Glu Asp Val Pro Thr Cys Gly Asp 
                405                 410                 415     


Ser Cys Asp Lys Val Leu Glu Cys Gly Ile His Arg Cys Ser Gln Arg 
            420                 425                 430         


Cys His Arg Gly Pro Cys Glu Thr Cys Arg Gln Glu Val Glu Lys His 
        435                 440                 445             


Cys Arg Cys Gly Lys His Thr Lys Arg Met Pro Cys His Lys Pro Tyr 
    450                 455                 460                 


Leu Cys Glu Thr Lys Cys Val Lys Met Arg Asp Cys Gln Lys His Gln 
465                 470                 475                 480 


Cys Arg Arg Lys Cys Cys Pro Gly Asn Cys Pro Pro Cys Asp Gln Asn 
                485                 490                 495     


Cys Gly Arg Thr Leu Gly Cys Arg Asn His Lys Cys Pro Ser Val Cys 
            500                 505                 510         


His Arg Gly Ser Cys Tyr Pro Cys Pro Glu Thr Val Asp Val Lys Cys 
        515                 520                 525             


Asn Cys Gly Asn Thr Lys Val Thr Val Pro Cys Gly Arg Glu Arg Thr 
    530                 535                 540                 


Thr Arg Pro Pro Lys Cys Lys Glu Gln Cys Ser Arg Pro Pro Thr Cys 
545                 550                 555                 560 


His His Thr Ser Gln Glu Lys His Arg Cys His Phe Gly Ser Cys Pro 
                565                 570                 575     


Pro Cys His Gln Pro Cys Gln Lys Val Leu Glu Lys Cys Gly His Leu 
            580                 585                 590         


Cys Pro Ala Pro Cys His Asp Gln Ala Leu Ile Lys Gln Thr Gly Arg 
        595                 600                 605             


His Gln Pro Thr Gly Pro Trp Glu Gln Pro Ser Glu Pro Ala Phe Ile 
    610                 615                 620                 


Gln Thr Ala Leu Pro Cys Pro Pro Cys Gln Val Pro Ile Pro Met Glu 
625                 630                 635                 640 


Cys Leu Gly Lys His Glu Val Ser Pro Leu Pro Cys His Ala Val Gly 
                645                 650                 655     


Pro Tyr Ser Cys Lys Arg Val Cys Gly Arg Ile Leu Asp Cys Gln Asn 
            660                 665                 670         


His Thr Cys Met Lys Glu Cys His Lys Val Thr Lys Thr Asp Gly Cys 
        675                 680                 685             


Thr Gly Lys Asn Lys Ala Gly Pro Glu Cys Leu His Cys Glu Glu Gly 
    690                 695                 700                 


Cys Ser Lys Ser Arg Pro Leu Gly Cys Leu His Pro Cys Ile Leu Arg 
705                 710                 715                 720 


Cys His Pro Gly Glu Cys Pro Pro Cys Val Gln Met Leu Arg Ile Lys 
                725                 730                 735     


Cys His Cys Lys Ile Thr Ser Leu Tyr Val Glu Cys Arg Lys Ile Thr 
            740                 745                 750         


Thr Ala Asp Val Asn Glu Lys Asn Leu Leu Ser Cys Cys Lys Asn Gln 
        755                 760                 765             


Cys Pro Lys Glu Leu Pro Cys Gly His Arg Cys Lys Glu Met Cys His 
    770                 775                 780                 


Pro Gly Glu Cys Pro Phe Asn Cys Asn Gln Lys Val Lys Leu Arg Cys 
785                 790                 795                 800 


Pro Cys Lys Arg Ile Lys Lys Glu Leu Gln Cys Asn Lys Val Arg Glu 
                805                 810                 815     


Asn Gln Val Ser Ile Glu Cys Asp Thr Thr Cys Lys Glu Met Lys Arg 
            820                 825                 830         


Lys Ala Ser Glu Ile Lys Glu Ala Glu Ala Lys Ala Ala Leu Glu Glu 
        835                 840                 845             


Glu Lys Arg Arg Gln Gln Ala Glu Leu Glu Ala Phe Glu Asn Arg Leu 
    850                 855                 860                 


Lys Gly Arg Arg Lys Lys Asn Arg Lys Arg Asp Glu Val Ala Val Glu 
865                 870                 875                 880 


Leu Ser Leu Trp Gln Lys His Lys Tyr Tyr Leu Ile Ser Val Cys Gly 
                885                 890                 895     


Val Val Val Val Val Phe Ala Trp Tyr Ile Thr His Asp Val Asn 
            900                 905                 910     


<210>  6143
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  6143

Met Ala Cys Ile Leu Lys Arg Lys Ser Val Ile Ala Val Ser Phe Ile 
1               5                   10                  15      


Ala Ala Phe Leu Phe Leu Leu Val Val Arg Leu Val Asn Glu Val Asn 
            20                  25                  30          


Phe Pro Leu Leu Leu Asn Cys Phe Gly Gln Pro Gly Thr Lys Trp Ile 
        35                  40                  45              


Pro Phe Ser Tyr Thr Tyr Arg Arg Pro Leu Arg Thr His Tyr Gly Tyr 
    50                  55                  60                  


Ile Asn Val Lys Thr Gln Glu Pro Leu Gln Leu Asp Cys Asp Leu Cys 
65                  70                  75                  80  


Ala Ile Val Ser Asn Ser Gly Gln Met Val Gly Gln Lys Val Gly Asn 
                85                  90                  95      


Glu Ile Asp Arg Ser Ser Cys Ile Trp Arg Met Asn Asn Ala Pro Thr 
            100                 105                 110         


Lys Gly Tyr Glu Glu Asp Val Gly Arg Met Thr Met Ile Arg Val Val 
        115                 120                 125             


Ser His Thr Ser Val Pro Leu Leu Leu Lys Asn Pro Asp Tyr Phe Phe 
    130                 135                 140                 


Lys Glu Ala Asn Thr Thr Ile Tyr Val Ile Trp Gly Pro Phe Arg Asn 
145                 150                 155                 160 


Met Arg Lys Asp Gly Asn Gly Ile Val Tyr Asn Met Leu Lys Lys Thr 
                165                 170                 175     


Val Gly Ile Tyr Pro Asn Ala Gln Ile Tyr Val Thr Thr Glu Lys Arg 
            180                 185                 190         


Met Ser Tyr Cys Asp Gly Val Phe Lys Lys Glu Thr Gly Lys Asp Arg 
        195                 200                 205             


Val Gln Ser Gly Ser Tyr Leu Ser Thr Gly Trp Phe Thr Phe Leu Leu 
    210                 215                 220                 


Ala Met Asp Ala Cys Tyr Gly Ile His Val Tyr Gly Met Ile Asn Asp 
225                 230                 235                 240 


Thr Tyr Cys Lys Thr Glu Gly Tyr Arg Lys Val Pro Tyr His Tyr Tyr 
                245                 250                 255     


Glu Gln Gly Arg Asp Glu Cys Asp Glu Tyr Phe Leu His Glu His Ala 
            260                 265                 270         


Pro Tyr Gly Gly His Arg Phe Ile Thr Glu Lys Lys Val Phe Ala Lys 
        275                 280                 285             


Trp Ala Lys Lys His Arg Ile Ile Phe Thr His Pro Asn Trp Thr Leu 
    290                 295                 300                 


Ser 
305 


<210>  6144
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  6144

Met Lys Lys Val Leu Leu Leu Ile Thr Ala Ile Leu Ala Val Ala Val 
1               5                   10                  15      


Gly Phe Pro Val Ser Gln Asp Gln Glu Arg Glu Lys Arg Ser Ile Ser 
            20                  25                  30          


Asp Ser Asp Glu Leu Ala Ser Gly Phe Phe Val Phe Pro Tyr Pro Tyr 
        35                  40                  45              


Pro Phe Arg Pro Leu Pro Pro Ile Pro Phe Pro Arg Phe Pro Trp Phe 
    50                  55                  60                  


Arg Arg Asn Phe Pro Ile Pro Ile Pro Glu Ser Ala Pro Thr Thr Pro 
65                  70                  75                  80  


Leu Pro Ser Glu Lys 
                85  


<210>  6145
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  6145

Met Glu Ser Ile Ser Met Met Gly Ser Pro Lys Ser Leu Ser Glu Thr 
1               5                   10                  15      


Phe Leu Pro Asn Gly Ile Asn Gly Ile Lys Asp Ala Arg Lys Val Thr 
            20                  25                  30          


Val Gly Val Ile Gly Ser Gly Asp Phe Ala Lys Ser Leu Thr Ile Arg 
        35                  40                  45              


Leu Ile Arg Cys Gly Tyr His Val Val Ile Gly Ser Arg Asn Pro Lys 
    50                  55                  60                  


Phe Ala Ser Glu Phe Phe Pro His Val Val Asp Val Thr His His Glu 
65                  70                  75                  80  


Asp Ala Leu Thr Lys Thr Asn Ile Ile Phe Val Ala Ile His Arg Glu 
                85                  90                  95      


His Tyr Thr Ser Leu Trp Asp Leu Arg His Leu Leu Val Gly Lys Ile 
            100                 105                 110         


Leu Ile Asp Val Ser Asn Asn Met Arg Ile Asn Gln Tyr Pro Glu Ser 
        115                 120                 125             


Asn Ala Glu Tyr Leu Ala Ser Leu Phe Pro Asp Ser Leu Ile Val Lys 
    130                 135                 140                 


Gly Phe Asn Val Val Ser Ala Trp Ala Leu Gln Leu Gly Pro Lys Asp 
145                 150                 155                 160 


Ala Ser Arg Gln Val Tyr Ile Cys Ser Asn Asn Ile Gln Ala Arg Gln 
                165                 170                 175     


Gln Val Ile Glu Leu Ala Arg Gln Leu Asn Phe Ile Pro Ile Asp Leu 
            180                 185                 190         


Gly Ser Leu Ser Ser Ala Arg Glu Ile Glu Asn Leu Pro Leu Arg Leu 
        195                 200                 205             


Phe Thr Leu Trp Arg Gly Pro Val Val Val Ala Ile Ser Leu Ala Thr 
    210                 215                 220                 


Phe Phe Phe Leu Tyr Ser Phe Val Arg Asp Val Ile His Pro Tyr Ala 
225                 230                 235                 240 


Arg Asn Gln Gln Ser Asp Phe Tyr Lys Ile Pro Ile Glu Ile Val Asn 
                245                 250                 255     


Lys Thr Leu Pro Ile Val Ala Ile Thr Leu Leu Ser Leu Val Tyr Leu 
            260                 265                 270         


Ala Gly Leu Leu Ala Ala Ala Tyr Gln Leu Tyr Tyr Gly Thr Lys Tyr 
        275                 280                 285             


Arg Arg Phe Pro Pro Trp Leu Glu Thr Trp Leu Gln Cys Arg Lys Gln 
    290                 295                 300                 


Leu Gly Leu Leu Ser Phe Phe Phe Ala Met Val His Val Ala Tyr Ser 
305                 310                 315                 320 


Leu Cys Leu Pro Met Arg Arg Ser Glu Arg Tyr Leu Phe Leu Asn Met 
                325                 330                 335     


Ala Tyr Gln Gln Val His Ala Asn Ile Glu Asn Ser Trp Asn Glu Glu 
            340                 345                 350         


Glu Val Trp Arg Ile Glu Met Tyr Ile Ser Phe Gly Ile Met Ser Leu 
        355                 360                 365             


Gly Leu Leu Ser Leu Leu Ala Val Thr Ser Ile Pro Ser Val Ser Asn 
    370                 375                 380                 


Ala Leu Asn Trp Arg Glu Phe Ser Phe Ile Gln Ser Thr Leu Gly Tyr 
385                 390                 395                 400 


Val Ala Leu Leu Ile Ser Thr Phe His Val Leu Ile Tyr Gly Trp Lys 
                405                 410                 415     


Arg Ala Phe Glu Glu Glu Tyr Tyr Arg Phe Tyr Thr Pro Pro Asn Phe 
            420                 425                 430         


Val Leu Ala Leu Val Leu Pro Ser Ile Val Ile Leu Gly Lys Ile Ile 
        435                 440                 445             


Leu Phe Leu Pro Cys Ile Ser Arg Lys Leu Lys Arg Ile Lys Lys Gly 
    450                 455                 460                 


Trp Glu Lys Ser Gln Phe Leu Glu Glu Gly Met Gly Gly Thr Ile Pro 
465                 470                 475                 480 


His Val Ser Pro Glu Arg Val Thr Val Met 
                485                 490 


<210>  6146
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  6146

Met Ser Trp Pro Arg Arg Leu Leu Leu Arg Tyr Leu Phe Pro Ala Leu 
1               5                   10                  15      


Leu Leu His Gly Leu Gly Glu Gly Ser Ala Leu Leu His Pro Asp Ser 
            20                  25                  30          


Arg Ser His Pro Arg Ser Leu Glu Lys Ser Ala Trp Arg Ala Phe Lys 
        35                  40                  45              


Glu Ser Gln Cys His His Met Leu Lys His Leu His Asn Gly Ala Arg 
    50                  55                  60                  


Ile Thr Val Gln Met Pro Pro Thr Ile Glu Gly His Trp Val Ser Thr 
65                  70                  75                  80  


Gly Cys Glu Val Arg Ser Gly Pro Glu Phe Ile Thr Arg Ser Tyr Arg 
                85                  90                  95      


Phe Tyr His Asn Asn Thr Phe Lys Ala Tyr Gln Phe Tyr Tyr Gly Ser 
            100                 105                 110         


Asn Arg Cys Thr Asn Pro Thr Tyr Thr Leu Ile Ile Arg Gly Lys Ile 
        115                 120                 125             


Arg Leu Arg Gln Ala Ser Trp Ile Ile Arg Gly Gly Thr Glu Ala Asp 
    130                 135                 140                 


Tyr Gln Leu His Asn Val Gln Val Ile Cys His Thr Glu Ala Val Ala 
145                 150                 155                 160 


Glu Lys Leu Gly Gln Gln Val Asn Arg Thr Cys Pro Gly Phe Leu Ala 
                165                 170                 175     


Asp Gly Gly Pro Trp Val Gln Asp Val Ala Tyr Asp Leu Trp Arg Glu 
            180                 185                 190         


Glu Asn Gly Cys Glu Cys Thr Lys Ala Val Asn Phe Ala Met His Glu 
        195                 200                 205             


Leu Gln Leu Ile Arg Val Glu Lys Gln Tyr Leu His His Asn Leu Asp 
    210                 215                 220                 


His Leu Val Glu Glu Leu Phe Leu Gly Asp Ile His Thr Asp Ala Thr 
225                 230                 235                 240 


Gln Arg Met Phe Tyr Arg Pro Ser Ser Tyr Gln Pro Pro Leu Gln Asn 
                245                 250                 255     


Ala Lys Asn His Asp His Ala Cys Ile Ala Cys Arg Ile Ile Tyr Arg 
            260                 265                 270         


Ser Asp Glu His His Pro Pro Ile Leu Pro Pro Lys Ala Asp Leu Thr 
        275                 280                 285             


Ile Gly Leu His Gly Glu Trp Val Ser Gln Arg Cys Glu Val Arg Pro 
    290                 295                 300                 


Glu Val Leu Phe Leu Thr Arg His Phe Ile Phe His Asp Asn Asn Asn 
305                 310                 315                 320 


Thr Trp Glu Gly His Tyr Tyr His Tyr Ser Asp Pro Val Cys Lys His 
                325                 330                 335     


Pro Thr Phe Ser Ile Tyr Ala Arg Gly Arg Tyr Ser Arg Gly Val Leu 
            340                 345                 350         


Ser Ser Arg Val Met Gly Gly Thr Glu Phe Val Phe Lys Val Asn His 
        355                 360                 365             


Met Lys Val Thr Pro Met Asp Ala Ala Thr Ala Ser Leu Leu Asn Val 
    370                 375                 380                 


Phe Asn Gly Asn Glu Cys Gly Ala Glu Gly Ser Trp Gln Val Gly Ile 
385                 390                 395                 400 


Gln Gln Asp Val Thr His Thr Asn Gly Cys Val Ala Leu Gly Ile Lys 
                405                 410                 415     


Leu Pro His Thr Glu Tyr Glu Ile Phe Lys Met Glu Gln Asp Ala Arg 
            420                 425                 430         


Gly Arg Tyr Leu Leu Phe Asn Gly Gln Arg Pro Ser Asp Gly Ser Ser 
        435                 440                 445             


Pro Asp Arg Pro Glu Lys Arg Ala Thr Ser Tyr Gln Met Pro Leu Val 
    450                 455                 460                 


Gln Cys Ala Ser Ser Ser Pro Arg Ala Glu Asp Leu Ala Glu Asp Ser 
465                 470                 475                 480 


Gly Ser Ser Leu Tyr Gly Arg Ala Pro Gly Arg His Thr Trp Ser Leu 
                485                 490                 495     


Leu Leu Ala Ala Leu Ala Cys Leu Val Pro Leu Leu His Trp Asn Ile 
            500                 505                 510         


Arg Arg 
        


<210>  6147
<211>  814
<212>  PRT
<213>  Homo sapiens

<400>  6147

Met Glu Pro Glu Ile Asn Cys Ser Glu Leu Cys Asp Ser Phe Pro Gly 
1               5                   10                  15      


Gln Glu Leu Asp Arg Arg Pro Leu His Asp Leu Cys Lys Thr Thr Ile 
            20                  25                  30          


Thr Ser Ser His His Ser Ser Lys Thr Ile Ser Ser Leu Ser Pro Val 
        35                  40                  45              


Leu Leu Gly Ile Val Trp Thr Phe Leu Ser Cys Gly Leu Leu Leu Ile 
    50                  55                  60                  


Leu Phe Phe Leu Ala Phe Thr Ile His Cys Arg Lys Asn Arg Ile Val 
65                  70                  75                  80  


Lys Met Ser Ser Pro Asn Leu Asn Ile Val Thr Leu Leu Gly Ser Cys 
                85                  90                  95      


Leu Thr Tyr Ser Ser Ala Tyr Leu Phe Gly Ile Gln Asp Val Leu Val 
            100                 105                 110         


Gly Ser Ser Met Glu Thr Leu Ile Gln Thr Arg Leu Ser Met Leu Cys 
        115                 120                 125             


Ile Gly Thr Ser Leu Val Phe Gly Pro Ile Leu Gly Lys Ser Trp Arg 
    130                 135                 140                 


Leu Tyr Lys Val Phe Thr Gln Arg Val Pro Asp Lys Arg Val Ile Ile 
145                 150                 155                 160 


Lys Asp Leu Gln Leu Leu Gly Leu Val Ala Ala Leu Leu Met Ala Asp 
                165                 170                 175     


Val Ile Leu Leu Met Thr Trp Val Leu Thr Asp Pro Ile Gln Cys Leu 
            180                 185                 190         


Gln Ile Leu Ser Val Ser Met Thr Val Thr Gly Lys Asp Val Ser Cys 
        195                 200                 205             


Thr Ser Thr Ser Thr His Phe Cys Ala Ser Arg Tyr Ser Asp Val Trp 
    210                 215                 220                 


Ile Ala Leu Ile Trp Gly Cys Lys Gly Leu Leu Leu Leu Tyr Gly Ala 
225                 230                 235                 240 


Tyr Leu Ala Gly Leu Thr Gly His Val Ser Ser Pro Pro Val Asn Gln 
                245                 250                 255     


Ser Leu Thr Ile Met Val Gly Val Asn Leu Leu Val Leu Ala Ala Gly 
            260                 265                 270         


Leu Leu Phe Val Val Thr Arg Tyr Leu His Ser Trp Pro Asn Leu Val 
        275                 280                 285             


Phe Gly Leu Thr Ser Gly Gly Ile Phe Val Cys Thr Thr Thr Ile Asn 
    290                 295                 300                 


Cys Phe Ile Phe Ile Pro Gln Leu Lys Gln Trp Lys Ala Phe Glu Glu 
305                 310                 315                 320 


Glu Asn Gln Thr Ile Arg Arg Met Ala Lys Tyr Phe Ser Thr Pro Asn 
                325                 330                 335     


Lys Ser Phe His Thr Gln Tyr Gly Glu Glu Glu Asn Cys His Pro Arg 
            340                 345                 350         


Gly Glu Lys Ser Ser Met Glu Arg Leu Leu Thr Glu Lys Asn Ala Val 
        355                 360                 365             


Ile Glu Ser Leu Gln Glu Gln Val Asn Asn Ala Lys Glu Lys Ile Val 
    370                 375                 380                 


Arg Leu Met Ser Ala Glu Cys Thr Tyr Asp Leu Pro Glu Gly Ala Ala 
385                 390                 395                 400 


Pro Pro Ala Ser Ser Pro Asn Lys Asp Val Gln Ala Val Ala Ser Val 
                405                 410                 415     


His Thr Leu Ala Ala Ala Gln Gly Pro Ser Gly His Leu Ser Asp Phe 
            420                 425                 430         


Gln Asn Asp Pro Gly Met Ala Ala Arg Asp Ser Gln Cys Thr Ser Gly 
        435                 440                 445             


Pro Ser Ser Tyr Ala Gln Ser Leu Glu Gly Pro Gly Lys Asp Ser Ser 
    450                 455                 460                 


Phe Ser Pro Gly Lys Glu Glu Lys Ile Ser Asp Ser Lys Asp Phe Ser 
465                 470                 475                 480 


Asp His Leu Asp Ser Gly Cys Ser Gln Lys Pro Trp Thr Glu Gln Ser 
                485                 490                 495     


Leu Gly Pro Glu Arg Gly Asp Gln Val Pro Met Asn Pro Ser Gln Ser 
            500                 505                 510         


Leu Leu Pro Glu Arg Gly Gly Ser Asp Pro Gln Arg Gln Arg His Leu 
        515                 520                 525             


Glu Asn Ser Glu Glu Pro Pro Glu Arg Arg Ser Arg Val Ser Ser Val 
    530                 535                 540                 


Ile Arg Glu Lys Leu Gln Glu Val Leu Gln Asp Leu Gly Leu Gly Pro 
545                 550                 555                 560 


Glu Ala Ser Leu Ser Thr Ala Pro Ser Cys His Gln Gln Thr Trp Lys 
                565                 570                 575     


Asn Ser Ala Ala Phe Ser Pro Gln Lys Met Pro Leu Ser Lys Glu Leu 
            580                 585                 590         


Gly Phe Ser Pro Tyr Met Val Arg Arg Arg Arg Ala Ala Gln Arg Ala 
        595                 600                 605             


Arg Ser His Phe Pro Gly Ser Ala Pro Ser Ser Val Gly His Arg Ala 
    610                 615                 620                 


Asn Arg Thr Val Pro Gly Ala His Ser Arg Leu His Val Gln Asn Gly 
625                 630                 635                 640 


Asp Ser Pro Ser Leu Ala Pro Gln Thr Thr Asp Ser Arg Val Arg Arg 
                645                 650                 655     


Pro Ser Ser Arg Lys Pro Ser Leu Pro Ser Asp Pro Gln Asp Arg Pro 
            660                 665                 670         


Gly Thr Leu Glu Gly Ser Lys Gln Ser Gln Thr Glu Pro Glu Gly Ala 
        675                 680                 685             


Arg Gly Ser Lys Ala Ala Phe Leu Arg Gln Pro Ser Gly Ser Gly Arg 
    690                 695                 700                 


Ala Pro Ser Pro Ala Ala Pro Cys Leu Ser Lys Ala Ser Pro Asp Leu 
705                 710                 715                 720 


Pro Glu Gln Trp Gln Leu Trp Pro Pro Val Pro Ser Gly Cys Ala Ser 
                725                 730                 735     


Leu Ser Ser Gln His Ser Tyr Phe Asp Thr Glu Ser Ser Ser Ser Asp 
            740                 745                 750         


Glu Phe Phe Cys Arg Cys His Arg Pro Tyr Cys Glu Ile Cys Phe Gln 
        755                 760                 765             


Ser Ser Ser Asp Ser Ser Asp Ser Gly Thr Ser Asp Thr Asp Pro Glu 
    770                 775                 780                 


Pro Thr Gly Gly Leu Ala Ser Trp Glu Lys Leu Trp Ala Arg Ser Lys 
785                 790                 795                 800 


Pro Ile Val Asn Phe Lys Asp Asp Leu Lys Pro Thr Leu Val 
                805                 810                 


<210>  6148
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  6148

Met Asp Ala Glu Tyr Ser Gly Asn Glu Phe Pro Arg Ser Glu Gly Glu 
1               5                   10                  15      


Arg Asp Gln His Gln Arg Pro Gly Lys Glu Arg Lys Ser Gly Glu Ala 
            20                  25                  30          


Gly Trp Gly Thr Gly Glu Leu Gly Gln Asp Gly Arg Leu Leu Ser Ser 
        35                  40                  45              


Thr Leu Ser Leu Ser Ser Asn Arg Ser Leu Gly Gln Arg Gln Asn Ser 
    50                  55                  60                  


Pro Leu Pro Phe Gln Trp Arg Ile Thr His Ser Phe Arg Trp Met Ala 
65                  70                  75                  80  


Gln Val Leu Ala Ser Glu Leu Ser Leu Val Ala Phe Ile Leu Leu Leu 
                85                  90                  95      


Val Val Ala Phe Ser Lys Lys Trp Leu Asp Leu Ser Arg Ser Leu Phe 
            100                 105                 110         


Tyr Gln Arg Trp Pro Val Asp Val Ser Asn Arg Ile His Thr Ser Ala 
        115                 120                 125             


His Val Met Ser Met Gly Leu Leu His Phe Tyr Lys Ser Arg Ser Cys 
    130                 135                 140                 


Ser Asp Leu Glu Asn Gly Lys Val Thr Phe Ile Phe Ser Thr Leu Met 
145                 150                 155                 160 


Leu Phe Pro Ile Asn Ile Trp Ile Phe Glu Leu Glu Arg Asn Val Ser 
                165                 170                 175     


Ile Pro Ile Gly Trp Ser Tyr Phe Ile Gly Trp Leu Val Leu Ile Leu 
            180                 185                 190         


Tyr Phe Thr Cys Ala Ile Leu Cys Tyr Phe Asn His Lys Ser Phe Trp 
        195                 200                 205             


Ser Leu Ile Leu Ser His Pro Ser Gly Ala Val Ser Cys Ser Ser Ser 
    210                 215                 220                 


Phe Gly Ser Val Glu Glu Ser Pro Arg Ala Gln Thr Ile Thr Asp Thr 
225                 230                 235                 240 


Pro Ile Thr Gln Glu Gly Val Leu Asp Pro Glu Gln Lys Asp Thr His 
                245                 250                 255     


Val 
    


<210>  6149
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  6149

Met Glu Leu His Tyr Leu Ala Lys Lys Ser Asn Gln Ala Asp Leu Cys 
1               5                   10                  15      


Asp Ala Arg Asp Trp Ser Ser Arg Gly Leu Pro Gly Asp Gln Ala Asp 
            20                  25                  30          


Thr Ala Ala Thr Arg Ala Ala Leu Cys Cys Gln Lys Gln Cys Ala Ser 
        35                  40                  45              


Thr Pro Arg Ala Thr Glu Met Glu Gly Ser Lys Leu Ser Ser Ser Pro 
    50                  55                  60                  


Ala Ser Pro Ser Ser Ser Leu Gln Asn Ser Thr Leu Gln Pro Asp Ala 
65                  70                  75                  80  


Phe Pro Pro Gly Leu Leu His Ser Gly Asn Asn Gln Ile Thr Ala Glu 
                85                  90                  95      


Arg Lys Val Cys Asn Cys Cys Ser Gln Glu Leu Glu Thr Ser Phe Thr 
            100                 105                 110         


Tyr Val Asp Lys Asn Ile Asn Leu Glu Gln Arg Asn Arg Ser Ser Pro 
        115                 120                 125             


Ser Ala Lys Gly His Asn His Pro Gly Glu Leu Gly Trp Glu Asn Pro 
    130                 135                 140                 


Asn Glu Trp Ser Gln Glu Ala Ala Ile Ser Leu Ile Ser Glu Glu Glu 
145                 150                 155                 160 


Asp Asp Thr Ser Ser Glu Ala Thr Ser Ser Gly Lys Ser Ile Asp Tyr 
                165                 170                 175     


Gly Phe Ile Ser Ala Ile Leu Phe Leu Val Thr Gly Ile Leu Leu Val 
            180                 185                 190         


Ile Ile Ser Tyr Ile Val Pro Arg Glu Val Thr Val Asp Pro Asn Thr 
        195                 200                 205             


Val Ala Ala Arg Glu Met Glu Arg Leu Glu Lys Glu Ser Ala Arg Leu 
    210                 215                 220                 


Gly Ala His Leu Asp Arg Cys Val Ile Ala Gly Leu Cys Leu Leu Thr 
225                 230                 235                 240 


Leu Gly Gly Val Ile Leu Ser Cys Leu Leu Met Met Ser Met Trp Lys 
                245                 250                 255     


Gly Glu Leu Tyr Arg Arg Asn Arg Phe Ala Ser Ser Lys Glu Ser Ala 
            260                 265                 270         


Lys Leu Tyr Gly Ser Phe Asn Phe Arg Met Lys Thr Ser Thr Asn Glu 
        275                 280                 285             


Asn Thr Leu Glu Leu Ser Leu Val Glu Glu Asp Ala Leu Ala Val Gln 
    290                 295                 300                 


Ser 
305 


<210>  6150
<211>  1458
<212>  PRT
<213>  Homo sapiens

<400>  6150

Met Gly Leu Arg Pro Gly Ile Phe Leu Leu Glu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Gly Gln Gly Thr Pro Gln Ile His Thr Ser Pro Arg Lys Ser Thr Leu 
            20                  25                  30          


Glu Gly Gln Leu Trp Pro Glu Thr Leu Lys Asn Ser Pro Phe Pro Cys 
        35                  40                  45              


Asn Pro Asn Lys Leu Gly Val Asn Met Pro Ser Lys Ser Val His Ser 
    50                  55                  60                  


Leu Lys Pro Ser Asp Ile Lys Phe Val Ala Ala Ile Gly Asn Leu Glu 
65                  70                  75                  80  


Ile Pro Pro Asp Pro Gly Thr Gly Asp Leu Glu Lys Gln Asp Trp Thr 
                85                  90                  95      


Glu Arg Pro Gln Gln Val Cys Met Gly Val Met Thr Val Leu Ser Asp 
            100                 105                 110         


Ile Ile Arg Tyr Phe Ser Pro Ser Val Pro Met Pro Val Cys His Thr 
        115                 120                 125             


Gly Lys Arg Val Ile Pro His Asp Gly Ala Glu Asp Leu Trp Ile Gln 
    130                 135                 140                 


Ala Gln Glu Leu Val Arg Asn Met Lys Glu Asn Leu Gln Leu Asp Phe 
145                 150                 155                 160 


Gln Phe Asp Trp Lys Leu Ile Asn Val Phe Phe Ser Asn Ala Ser Gln 
                165                 170                 175     


Cys Tyr Leu Cys Pro Ser Ala Gln Gln Asn Gly Leu Ala Ala Gly Gly 
            180                 185                 190         


Val Asp Glu Leu Met Gly Val Leu Asp Tyr Leu Gln Gln Glu Val Pro 
        195                 200                 205             


Arg Ala Phe Val Asn Leu Val Asp Leu Ser Glu Val Ala Glu Val Ser 
    210                 215                 220                 


Arg Gln Tyr His Gly Thr Trp Leu Ser Pro Ala Pro Glu Pro Cys Asn 
225                 230                 235                 240 


Cys Ser Glu Glu Thr Thr Arg Leu Ala Lys Val Val Met Gln Trp Ser 
                245                 250                 255     


Tyr Gln Glu Ala Trp Asn Ser Leu Leu Ala Ser Ser Arg Tyr Ser Glu 
            260                 265                 270         


Gln Glu Ser Phe Thr Val Val Phe Gln Pro Phe Phe Tyr Glu Thr Thr 
        275                 280                 285             


Pro Ser Leu His Ser Glu Asp Pro Arg Leu Gln Asp Ser Thr Thr Leu 
    290                 295                 300                 


Ala Trp His Leu Trp Asn Arg Met Met Glu Pro Ala Gly Glu Lys Asp 
305                 310                 315                 320 


Glu Pro Leu Ser Val Lys His Gly Arg Pro Met Lys Cys Pro Ser Gln 
                325                 330                 335     


Glu Ser Pro Tyr Leu Phe Ser Tyr Arg Asn Ser Asn Tyr Leu Thr Arg 
            340                 345                 350         


Leu Gln Lys Pro Gln Asp Lys Leu Glu Val Arg Glu Gly Ala Glu Ile 
        355                 360                 365             


Arg Cys Pro Asp Lys Asp Pro Ser Asp Thr Val Pro Thr Ser Val His 
    370                 375                 380                 


Arg Leu Lys Pro Ala Asp Ile Asn Val Ile Gly Ala Leu Gly Asp Ser 
385                 390                 395                 400 


Leu Thr Ala Gly Asn Gly Ala Gly Ser Thr Pro Gly Asn Val Leu Asp 
                405                 410                 415     


Val Leu Thr Gln Tyr Arg Gly Leu Ser Trp Ser Val Gly Gly Asp Glu 
            420                 425                 430         


Asn Ile Gly Thr Val Thr Thr Leu Ala Asn Ile Leu Arg Glu Phe Asn 
        435                 440                 445             


Pro Ser Leu Lys Gly Phe Ser Val Gly Thr Gly Lys Glu Thr Ser Pro 
    450                 455                 460                 


Asn Ala Phe Leu Asn Gln Ala Val Ala Gly Gly Arg Ala Glu Asp Leu 
465                 470                 475                 480 


Pro Val Gln Ala Arg Arg Leu Val Asp Leu Met Lys Asn Asp Thr Arg 
                485                 490                 495     


Ile His Phe Gln Glu Asp Trp Lys Ile Ile Thr Leu Phe Ile Gly Gly 
            500                 505                 510         


Asn Asp Leu Cys Asp Phe Cys Asn Asp Leu Val His Tyr Ser Pro Gln 
        515                 520                 525             


Asn Phe Thr Asp Asn Ile Gly Lys Ala Leu Asp Ile Leu His Ala Glu 
    530                 535                 540                 


Val Pro Arg Ala Phe Val Asn Leu Val Thr Val Leu Glu Ile Val Asn 
545                 550                 555                 560 


Leu Arg Glu Leu Tyr Gln Glu Lys Lys Val Tyr Cys Pro Arg Met Ile 
                565                 570                 575     


Leu Arg Ser Leu Cys Pro Cys Val Leu Lys Phe Asp Asp Asn Ser Thr 
            580                 585                 590         


Glu Leu Ala Thr Leu Ile Glu Phe Asn Lys Lys Phe Gln Glu Lys Thr 
        595                 600                 605             


His Gln Leu Ile Glu Ser Gly Arg Tyr Asp Thr Arg Glu Asp Phe Thr 
    610                 615                 620                 


Val Val Val Gln Pro Phe Phe Glu Asn Val Asp Met Pro Lys Thr Ser 
625                 630                 635                 640 


Glu Gly Leu Pro Asp Asn Ser Phe Phe Ala Pro Asp Cys Phe His Phe 
                645                 650                 655     


Ser Ser Lys Ser His Ser Arg Ala Ala Ser Ala Leu Trp Asn Asn Met 
            660                 665                 670         


Leu Glu Pro Val Gly Gln Lys Thr Thr Arg His Lys Phe Glu Asn Lys 
        675                 680                 685             


Ile Asn Ile Thr Cys Pro Asn Gln Val Gln Pro Phe Leu Arg Thr Tyr 
    690                 695                 700                 


Lys Asn Ser Met Gln Gly His Gly Thr Trp Leu Pro Cys Arg Asp Arg 
705                 710                 715                 720 


Ala Pro Ser Ala Leu His Pro Thr Ser Val His Ala Leu Arg Pro Ala 
                725                 730                 735     


Asp Ile Gln Val Val Ala Ala Leu Gly Asp Ser Leu Thr Ala Gly Asn 
            740                 745                 750         


Gly Ile Gly Ser Lys Pro Asp Asp Leu Pro Asp Val Thr Thr Gln Tyr 
        755                 760                 765             


Arg Gly Leu Ser Tyr Ser Ala Gly Gly Asp Gly Ser Leu Glu Asn Val 
    770                 775                 780                 


Thr Thr Leu Pro Asn Ile Leu Arg Glu Phe Asn Arg Asn Leu Thr Gly 
785                 790                 795                 800 


Tyr Ala Val Gly Thr Gly Asp Ala Asn Asp Thr Asn Ala Phe Leu Asn 
                805                 810                 815     


Gln Ala Val Pro Gly Ala Lys Ala Glu Asp Leu Met Ser Gln Val Gln 
            820                 825                 830         


Thr Leu Met Gln Lys Met Lys Asp Asp His Arg Val Asn Phe His Glu 
        835                 840                 845             


Asp Trp Lys Val Ile Thr Val Leu Ile Gly Gly Ser Asp Leu Cys Asp 
    850                 855                 860                 


Tyr Cys Thr Asp Ser Asn Leu Tyr Ser Ala Ala Asn Phe Val His His 
865                 870                 875                 880 


Leu Arg Asn Ala Leu Asp Val Leu His Arg Glu Val Pro Arg Val Leu 
                885                 890                 895     


Val Asn Leu Val Asp Phe Leu Asn Pro Thr Ile Met Arg Gln Val Phe 
            900                 905                 910         


Leu Gly Asn Pro Asp Lys Cys Pro Val Gln Gln Ala Ser Val Leu Cys 
        915                 920                 925             


Asn Cys Val Leu Thr Leu Arg Glu Asn Ser Gln Glu Leu Ala Arg Leu 
    930                 935                 940                 


Glu Ala Phe Ser Arg Ala Tyr Arg Ser Ser Met Arg Glu Leu Val Gly 
945                 950                 955                 960 


Ser Gly Arg Tyr Asp Thr Gln Glu Asp Phe Ser Val Val Leu Gln Pro 
                965                 970                 975     


Phe Phe Gln Asn Ile Gln Leu Pro Val Leu Ala Asp Gly Leu Pro Asp 
            980                 985                 990         


Thr Ser Phe Phe Ala Pro Asp Cys  Ile His Pro Asn Gln  Lys Phe His 
        995                 1000                 1005             


Ser Gln  Leu Ala Arg Ala Leu  Trp Thr Asn Met Leu  Glu Pro Leu 
    1010                 1015                 1020             


Gly Ser  Lys Thr Glu Thr Leu  Asp Leu Arg Ala Glu  Met Pro Ile 
    1025                 1030                 1035             


Thr Cys  Pro Thr Gln Asn Glu  Pro Phe Leu Arg Thr  Pro Arg Asn 
    1040                 1045                 1050             


Ser Asn  Tyr Thr Tyr Pro Ile  Lys Pro Ala Ile Glu  Asn Trp Gly 
    1055                 1060                 1065             


Ser Asp  Phe Leu Cys Thr Glu  Trp Lys Ala Ser Asn  Ser Val Pro 
    1070                 1075                 1080             


Thr Ser  Val His Gln Leu Arg  Pro Ala Asp Ile Lys  Val Val Ala 
    1085                 1090                 1095             


Ala Leu  Gly Asp Ser Leu Thr  Thr Ala Val Gly Ala  Arg Pro Asn 
    1100                 1105                 1110             


Asn Ser  Ser Asp Leu Pro Thr  Ser Trp Arg Gly Leu  Ser Trp Ser 
    1115                 1120                 1125             


Ile Gly  Gly Asp Gly Asn Leu  Glu Thr His Thr Thr  Leu Pro Asn 
    1130                 1135                 1140             


Ile Leu  Lys Lys Phe Asn Pro  Tyr Leu Leu Gly Phe  Ser Thr Ser 
    1145                 1150                 1155             


Thr Trp  Glu Gly Thr Ala Gly  Leu Asn Val Ala Ala  Glu Gly Ala 
    1160                 1165                 1170             


Arg Ala  Arg Asp Met Pro Ala  Gln Ala Trp Asp Leu  Val Glu Arg 
    1175                 1180                 1185             


Met Lys  Asn Ser Pro Asp Ile  Asn Leu Glu Lys Asp  Trp Lys Leu 
    1190                 1195                 1200             


Val Thr  Leu Phe Ile Gly Val  Asn Asp Leu Cys His  Tyr Cys Glu 
    1205                 1210                 1215             


Asn Pro  Glu Ala His Leu Ala  Thr Glu Tyr Val Gln  His Ile Gln 
    1220                 1225                 1230             


Gln Ala  Leu Asp Ile Leu Ser  Glu Glu Leu Pro Arg  Ala Phe Val 
    1235                 1240                 1245             


Asn Val  Val Glu Val Met Glu  Leu Ala Ser Leu Tyr  Gln Gly Gln 
    1250                 1255                 1260             


Gly Gly  Lys Cys Ala Met Leu  Ala Ala Gln Asn Asn  Cys Thr Cys 
    1265                 1270                 1275             


Leu Arg  His Ser Gln Ser Ser  Leu Glu Lys Gln Glu  Leu Lys Lys 
    1280                 1285                 1290             


Val Asn  Trp Asn Leu Gln His  Gly Ile Ser Ser Phe  Ser Tyr Trp 
    1295                 1300                 1305             


His Gln  Tyr Thr Gln Arg Glu  Asp Phe Ala Val Val  Val Gln Pro 
    1310                 1315                 1320             


Phe Phe  Gln Asn Thr Leu Thr  Pro Leu Asn Glu Arg  Gly Asp Thr 
    1325                 1330                 1335             


Asp Leu  Thr Phe Phe Ser Glu  Asp Cys Phe His Phe  Ser Asp Arg 
    1340                 1345                 1350             


Gly His  Ala Glu Met Ala Ile  Ala Leu Trp Asn Asn  Met Leu Glu 
    1355                 1360                 1365             


Pro Val  Gly Arg Lys Thr Thr  Ser Asn Asn Phe Thr  His Ser Arg 
    1370                 1375                 1380             


Ala Lys  Leu Lys Cys Pro Ser  Pro Glu Ser Pro Tyr  Leu Tyr Thr 
    1385                 1390                 1395             


Leu Arg  Asn Ser Arg Leu Leu  Pro Asp Gln Ala Glu  Glu Ala Pro 
    1400                 1405                 1410             


Glu Val  Leu Tyr Trp Ala Val  Pro Val Ala Ala Gly  Val Gly Leu 
    1415                 1420                 1425             


Val Val  Gly Ile Ile Gly Thr  Val Val Trp Arg Cys  Arg Arg Gly 
    1430                 1435                 1440             


Gly Arg  Arg Glu Asp Pro Pro  Met Ser Leu Arg Thr  Val Ala Leu 
    1445                 1450                 1455             


<210>  6151
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  6151

Met Ser Trp Arg Pro Gln Pro Cys Cys Ile Ser Ser Cys Cys Leu Thr 
1               5                   10                  15      


Thr Asp Trp Val His Leu Trp Tyr Ile Trp Leu Leu Val Val Ile Gly 
            20                  25                  30          


Ala Leu Leu Leu Leu Cys Gly Leu Thr Ser Leu Cys Phe Arg Cys Cys 
        35                  40                  45              


Cys Leu Ser Arg Gln Gln Asn Gly Glu Asp Gly Gly Pro Pro Pro Cys 
    50                  55                  60                  


Glu Val Thr Val Ile Ala Phe Asp His Asp Ser Thr Leu Gln Ser Thr 
65                  70                  75                  80  


Ile Thr Ser Leu Gln Ser Val Phe Gly Pro Ala Ala Arg Arg Ile Leu 
                85                  90                  95      


Ala Val Ala His Ser His Ser Ser Leu Gly Gln Leu Pro Ser Ser Leu 
            100                 105                 110         


Asp Thr Leu Pro Gly Tyr Glu Glu Ala Leu His Met Ser Arg Phe Thr 
        115                 120                 125             


Val Ala Met Cys Gly Gln Lys Ala Pro Asp Leu Pro Pro Val Pro Glu 
    130                 135                 140                 


Glu Lys Gln Leu Pro Pro Thr Glu Lys Glu Ser Thr Arg Ile Val Asp 
145                 150                 155                 160 


Ser Trp Asn 
            


<210>  6152
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  6152

Met Leu Gly Trp Ile Leu Ile Thr Leu Ala Thr Ile Ala Ala Leu Val 
1               5                   10                  15      


Ser Cys Cys Val Ala Lys Cys Cys Ser Pro Leu Thr Ser Leu Gln His 
            20                  25                  30          


Cys Tyr Trp Thr Ser His Leu Gln Asn Glu Arg Glu Leu Phe Glu Gln 
        35                  40                  45              


Ala Ala Glu Gln His Ser Arg Leu Leu Met Met His Arg Ile Lys Lys 
    50                  55                  60                  


Leu Phe Gly Phe Ile Pro Gly Ser Glu Asp Val Lys His Ile Arg Ile 
65                  70                  75                  80  


Pro Ser Cys Gln Asp Trp Lys Asp Ile Ser Val Pro Thr Leu Leu Cys 
                85                  90                  95      


Met Gly Asp Asp Leu Gln Gly His Tyr Ser Phe Leu Gly Asn Arg Val 
            100                 105                 110         


Asp Glu Asp Asn Glu Glu Asp Arg Ser Arg Gly Ile Glu Leu Lys Pro 
        115                 120                 125             


<210>  6153
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  6153

Met Ala Cys Glu Pro Gln Val Asp Pro Gly Ala Thr Gly Pro Leu Pro 
1               5                   10                  15      


Pro Ser Ser Pro Gly Trp Ser Ala Leu Pro Gly Gly Ser Pro Pro Gly 
            20                  25                  30          


Trp Gly Gln Glu Leu His Asn Gly Gln Val Leu Thr Val Leu Arg Ile 
        35                  40                  45              


Asp Asn Thr Cys Ala Pro Ile Ser Phe Asp Leu Gly Ala Ala Glu Glu 
    50                  55                  60                  


Gln Leu Gln Thr Trp Gly Ile Gln Val Pro Ala Asp Gln Tyr Arg Ser 
65                  70                  75                  80  


Leu Ala Glu Ser Ala Leu Leu Glu Pro Gln Val Arg Arg Tyr Ile Ile 
                85                  90                  95      


Tyr Asn Ser Arg Pro Met Arg Leu Ala Phe Ala Val Val Phe Tyr Val 
            100                 105                 110         


Val Val Trp Ala Asn Ile Tyr Ser Thr Ser Gln Met Phe Ala Leu Gly 
        115                 120                 125             


Asn His Trp Ala Gly Met Leu Leu Val Thr Leu Ala Ala Val Ser Leu 
    130                 135                 140                 


Thr Leu Thr Leu Val Leu Val Phe Glu Arg His Gln Lys Lys Ala Asn 
145                 150                 155                 160 


Thr Asn Thr Asp Leu Arg Leu Ala Ala Ala Asn Gly Ala Leu Leu Arg 
                165                 170                 175     


His Arg Val Leu Leu Gly Val Thr Asp Thr Val Glu Gly Cys Gln Ser 
            180                 185                 190         


Val Ile Gln Leu Trp Phe Val Tyr Phe Asp Leu Glu Asn Cys Val Gln 
        195                 200                 205             


Phe Leu Ser Asp His Val Gln Glu Met Lys Thr Ser Gln Glu Ser Leu 
    210                 215                 220                 


Leu Arg Ser Arg Leu Ser Gln Leu Cys Val Val Met Glu Thr Gly Val 
225                 230                 235                 240 


Ser Pro Ala Thr Ala Glu Gly Pro Glu Asn Leu Glu Asp Ala Pro Leu 
                245                 250                 255     


Leu Pro Gly Asn Ser Cys Pro Asn Glu Arg Pro Leu Met Gln Thr Glu 
            260                 265                 270         


Leu His Gln Leu Val Pro Glu Ala Glu Pro Glu Glu Met Ala Arg Gln 
        275                 280                 285             


Leu Leu Ala Val Phe Gly Gly Tyr Tyr Ile Arg Leu Leu Val Thr Ser 
    290                 295                 300                 


Gln Leu Pro Gln Ala Met Gly Thr Arg His Thr Asn Ser Pro Arg Ile 
305                 310                 315                 320 


Pro Cys Pro Cys Gln Leu Ile Glu Ala Tyr Ile Leu Gly Thr Gly Cys 
                325                 330                 335     


Cys Pro Phe Leu Ala Arg 
            340         


<210>  6154
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  6154

Met Phe Val Leu Phe Leu Cys Asn Leu Ser Leu Val Pro Ala Ala Ala 
1               5                   10                  15      


Ser Lys Asn Lys Val Lys Gly Ser Gln Gly Gln Phe Pro Leu Thr Gln 
            20                  25                  30          


Asn Val Thr Val Val Glu Gly Gly Thr Ala Ile Leu Thr Cys Arg Val 
        35                  40                  45              


Asp Gln Asn Asp Asn Thr Ser Leu Gln Trp Ser Asn Pro Ala Gln Gln 
    50                  55                  60                  


Thr Leu Tyr Phe Asp Asp Lys Lys Ala Leu Arg Asp Asn Arg Ile Glu 
65                  70                  75                  80  


Leu Val Arg Ala Ser Trp His Glu Leu Ser Ile Ser Val Ser Asp Val 
                85                  90                  95      


Ser Leu Ser Asp Glu Gly Gln Tyr Thr Cys Ser Leu Phe Thr Met Pro 
            100                 105                 110         


Val Lys Thr Ser Lys Ala Tyr Leu Thr Val Leu Gly Val Pro Glu Lys 
        115                 120                 125             


Pro Gln Ile Ser Gly Phe Ser Ser Pro Val Met Glu Gly Asp Leu Met 
    130                 135                 140                 


Gln Leu Thr Cys Lys Thr Ser Gly Ser Lys Pro Ala Ala Asp Ile Arg 
145                 150                 155                 160 


Trp Phe Lys Asn Asp Lys Glu Ile Lys Asp Val Lys Tyr Leu Lys Glu 
                165                 170                 175     


Glu Asp Ala Asn Arg Lys Thr Phe Thr Val Ser Ser Thr Leu Asp Phe 
            180                 185                 190         


Arg Val Asp Arg Ser Asp Asp Gly Val Ala Val Ile Cys Arg Val Asp 
        195                 200                 205             


His Glu Ser Leu Asn Ala Thr Pro Gln Val Ala Met Gln Val Leu Glu 
    210                 215                 220                 


Ile His Tyr Thr Pro Ser Val Lys Ile Ile Pro Ser Thr Pro Phe Pro 
225                 230                 235                 240 


Gln Glu Gly Gln Pro Leu Ile Leu Thr Cys Glu Ser Lys Gly Lys Pro 
                245                 250                 255     


Leu Pro Glu Pro Val Leu Trp Thr Lys Asp Gly Gly Glu Leu Pro Asp 
            260                 265                 270         


Pro Asp Arg Met Val Val Ser Gly Arg Glu Leu Asn Ile Leu Phe Leu 
        275                 280                 285             


Asn Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Thr Asn Thr Ile 
    290                 295                 300                 


Gly Gln Ser Ser Ala Glu Tyr Val Leu Ile Val His Asp Val Pro Asn 
305                 310                 315                 320 


Thr Leu Leu Pro Thr Thr Ile Ile Pro Ser Leu Thr Thr Ala Thr Val 
                325                 330                 335     


Thr Thr Thr Val Ala Ile Thr Thr Ser Pro Thr Thr Ser Ala Thr Thr 
            340                 345                 350         


Ser Ser Ile Arg Asp Pro Asn Ala Leu Ala Gly Gln Asn Gly Pro Asp 
        355                 360                 365             


His Ala Leu Ile Gly Gly Ile Val Ala Val Val Val Phe Val Thr Leu 
    370                 375                 380                 


Cys Ser Ile Phe Leu Leu Gly Arg Tyr Leu Ala Arg His Lys Gly Thr 
385                 390                 395                 400 


Tyr Leu Thr Asn Glu Ala Lys Gly Ala Glu Asp Ala Pro Asp Ala Asp 
                405                 410                 415     


Thr Ala Ile Ile Asn Ala Glu Gly Ser Gln Val Asn Ala Glu Glu Lys 
            420                 425                 430         


Lys Glu Tyr Phe Ile 
        435         


<210>  6155
<211>  506
<212>  PRT
<213>  Homo sapiens

<400>  6155

Met Pro Thr Val Asp Asp Ile Leu Glu Gln Val Gly Glu Ser Gly Trp 
1               5                   10                  15      


Phe Gln Lys Gln Ala Phe Leu Ile Leu Cys Leu Leu Ser Ala Ala Phe 
            20                  25                  30          


Ala Pro Ile Cys Val Gly Ile Val Phe Leu Gly Phe Thr Pro Asp His 
        35                  40                  45              


His Cys Gln Ser Pro Gly Val Ala Glu Leu Ser Gln Arg Cys Gly Trp 
    50                  55                  60                  


Ser Pro Ala Glu Glu Leu Asn Tyr Thr Val Pro Gly Leu Gly Pro Ala 
65                  70                  75                  80  


Gly Glu Ala Phe Leu Gly Gln Cys Arg Arg Tyr Glu Val Asp Trp Asn 
                85                  90                  95      


Gln Ser Ala Leu Ser Cys Val Asp Pro Leu Ala Ser Leu Ala Thr Asn 
            100                 105                 110         


Arg Ser His Leu Pro Leu Gly Pro Cys Gln Asp Gly Trp Val Tyr Asp 
        115                 120                 125             


Thr Pro Gly Ser Ser Ile Val Thr Glu Phe Asn Leu Val Cys Ala Asp 
    130                 135                 140                 


Ser Trp Lys Leu Asp Leu Phe Gln Ser Cys Leu Asn Ala Gly Phe Leu 
145                 150                 155                 160 


Phe Gly Ser Leu Gly Val Gly Tyr Phe Ala Asp Arg Phe Gly Arg Lys 
                165                 170                 175     


Leu Cys Leu Leu Gly Thr Val Leu Val Asn Ala Val Ser Gly Val Leu 
            180                 185                 190         


Met Ala Phe Ser Pro Asn Tyr Met Ser Met Leu Leu Phe Arg Leu Leu 
        195                 200                 205             


Gln Gly Leu Val Ser Lys Gly Asn Trp Met Ala Gly Tyr Thr Leu Ile 
    210                 215                 220                 


Thr Glu Phe Val Gly Ser Gly Ser Arg Arg Thr Val Ala Ile Met Tyr 
225                 230                 235                 240 


Gln Met Ala Phe Thr Val Gly Leu Val Ala Leu Thr Gly Leu Ala Tyr 
                245                 250                 255     


Ala Leu Pro His Trp Arg Trp Leu Gln Leu Ala Val Ser Leu Pro Thr 
            260                 265                 270         


Phe Leu Phe Leu Leu Tyr Tyr Trp Cys Val Pro Glu Ser Pro Arg Trp 
        275                 280                 285             


Leu Leu Ser Gln Lys Arg Asn Thr Glu Ala Ile Lys Ile Met Asp His 
    290                 295                 300                 


Ile Ala Gln Lys Asn Gly Lys Leu Pro Pro Ala Asp Leu Lys Met Leu 
305                 310                 315                 320 


Ser Leu Glu Glu Asp Val Thr Glu Lys Leu Ser Pro Ser Phe Ala Asp 
                325                 330                 335     


Leu Phe Arg Thr Pro Arg Leu Arg Lys Arg Thr Phe Ile Leu Met Tyr 
            340                 345                 350         


Leu Trp Phe Thr Asp Ser Val Leu Tyr Gln Gly Leu Ile Leu His Met 
        355                 360                 365             


Gly Ala Thr Ser Gly Asn Leu Tyr Leu Asp Phe Leu Tyr Ser Ala Leu 
    370                 375                 380                 


Val Glu Ile Pro Gly Ala Phe Ile Ala Leu Ile Thr Ile Asp Arg Val 
385                 390                 395                 400 


Gly Arg Ile Tyr Pro Met Ala Met Ser Asn Leu Leu Ala Gly Ala Ala 
                405                 410                 415     


Cys Leu Val Met Ile Phe Ile Ser Pro Asp Leu His Trp Leu Asn Ile 
            420                 425                 430         


Ile Ile Met Cys Val Gly Arg Met Gly Ile Thr Ile Ala Ile Gln Met 
        435                 440                 445             


Ile Cys Leu Val Asn Ala Glu Leu Tyr Pro Thr Phe Val Ser Gly Val 
    450                 455                 460                 


Gly Pro Ala Cys Arg Gly Ser Asp Ala Thr Ser Ser Arg Asp Gln Gly 
465                 470                 475                 480 


Gly Arg Phe Ala Arg Asp His Glu Gly Arg Arg Glu Pro Trp Glu Lys 
                485                 490                 495     


Ser Lys Ala Gln Arg Lys His Asp Leu Pro 
            500                 505     


<210>  6156
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  6156

Met Gly Val Leu Lys Phe Lys His Ile Phe Phe Arg Ser Phe Val Lys 
1               5                   10                  15      


Ser Ser Gly Val Ser Gln Ile Val Phe Thr Phe Leu Leu Ile Pro Cys 
            20                  25                  30          


Cys Leu Thr Leu Asn Phe Arg Ala Pro Pro Val Ile Pro Asn Val Pro 
        35                  40                  45              


Phe Leu Trp Ala Trp Asn Ala Pro Ser Glu Phe Cys Leu Gly Lys Phe 
    50                  55                  60                  


Asp Glu Pro Leu Asp Met Ser Leu Phe Ser Phe Ile Gly Ser Pro Arg 
65                  70                  75                  80  


Ile Asn Ala Thr Gly Gln Gly Val Thr Ile Phe Tyr Val Asp Arg Leu 
                85                  90                  95      


Gly Tyr Tyr Pro Tyr Ile Asp Ser Ile Thr Gly Val Thr Val Asn Gly 
            100                 105                 110         


Gly Ile Pro Gln Lys Ile Ser Leu Gln Asp His Leu Asp Lys Ala Lys 
        115                 120                 125             


Lys Asp Ile Thr Phe Tyr Met Pro Val Asp Asn Leu Gly Met Ala Val 
    130                 135                 140                 


Ile Asp Trp Glu Glu Trp Arg Pro Thr Trp Ala Arg Asn Trp Lys Pro 
145                 150                 155                 160 


Lys Asp Val Tyr Lys Asn Arg Ser Ile Glu Leu Val Gln Gln Gln Asn 
                165                 170                 175     


Val Gln Leu Ser Leu Thr Glu Ala Thr Glu Lys Ala Lys Gln Glu Phe 
            180                 185                 190         


Glu Lys Ala Gly Lys Asp Phe Leu Val Glu Thr Ile Lys Leu Gly Lys 
        195                 200                 205             


Leu Leu Arg Pro Asn His Leu Trp Gly Tyr Tyr Leu Phe Pro Asp Cys 
    210                 215                 220                 


Tyr Asn His His Tyr Lys Lys Pro Gly Tyr Asn Gly Ser Cys Phe Asn 
225                 230                 235                 240 


Val Glu Ile Lys Arg Asn Asp Asp Leu Ser Trp Leu Trp Asn Glu Ser 
                245                 250                 255     


Thr Ala Leu Tyr Pro Ser Ile Tyr Leu Asn Thr Gln Gln Ser Pro Val 
            260                 265                 270         


Ala Ala Thr Leu Tyr Val Arg Asn Arg Val Arg Glu Ala Ile Arg Val 
        275                 280                 285             


Ser Lys Ile Pro Asp Ala Lys Ser Pro Leu Pro Val Phe Ala Tyr Thr 
    290                 295                 300                 


Arg Ile Val Phe Thr Asp Gln Val Leu Lys Phe Leu Ser Gln Asp Glu 
305                 310                 315                 320 


Leu Val Tyr Thr Phe Gly Glu Thr Val Ala Leu Gly Ala Ser Gly Ile 
                325                 330                 335     


Val Ile Trp Gly Thr Leu Ser Ile Met Arg Ser Met Lys Ser Cys Leu 
            340                 345                 350         


Leu Leu Asp Asn Tyr Met Glu Thr Ile Leu Asn Pro Tyr Ile Ile Asn 
        355                 360                 365             


Val Thr Leu Ala Ala Lys Met Cys Ser Gln Val Leu Cys Gln Glu Gln 
    370                 375                 380                 


Gly Val Cys Ile Arg Lys Asn Trp Asn Ser Ser Asp Tyr Leu His Leu 
385                 390                 395                 400 


Asn Pro Asp Asn Phe Ala Ile Gln Leu Glu Lys Gly Gly Lys Phe Thr 
                405                 410                 415     


Val Arg Gly Lys Pro Thr Leu Glu Asp Leu Glu Gln Phe Ser Glu Lys 
            420                 425                 430         


Phe Tyr Cys Ser Cys Tyr Ser Thr Leu Ser Cys Lys Glu Lys Ala Asp 
        435                 440                 445             


Val Lys Asp Thr Asp Ala Val Asp Val Cys Ile Ala Asp Gly Val Cys 
    450                 455                 460                 


Ile Asp Ala Phe Leu Lys Pro Pro Met Glu Thr Glu Glu Pro Gln Ile 
465                 470                 475                 480 


Phe Tyr Asn Ala Ser Pro Ser Thr Leu Ser Ala Thr Met Phe Ile Val 
                485                 490                 495     


Ser Ile Leu Phe Leu Ile Ile Ser Ser Val Ala Ser Leu 
            500                 505                 


<210>  6157
<211>  787
<212>  PRT
<213>  Homo sapiens

<400>  6157

Met Gly Trp Arg Pro Arg Arg Ala Arg Gly Thr Pro Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Trp Pro Val Pro Gly Ala Gly Val Leu Gln 
            20                  25                  30          


Gly His Ile Pro Gly Gln Pro Val Thr Pro His Trp Val Leu Asp Gly 
        35                  40                  45              


Gln Pro Trp Arg Thr Val Ser Leu Glu Glu Pro Val Ser Lys Pro Asp 
    50                  55                  60                  


Met Gly Leu Val Ala Leu Glu Ala Glu Gly Gln Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Leu Glu Lys Asn His Arg Leu Leu Ala Pro Gly Tyr Ile Glu Thr His 
                85                  90                  95      


Tyr Gly Pro Asp Gly Gln Pro Val Val Leu Ala Pro Asn His Thr Asp 
            100                 105                 110         


His Cys His Tyr Gln Gly Arg Val Arg Gly Phe Pro Asp Ser Trp Val 
        115                 120                 125             


Val Leu Cys Thr Cys Ser Gly Met Ser Gly Leu Ile Thr Leu Ser Arg 
    130                 135                 140                 


Asn Ala Ser Tyr Tyr Leu Arg Pro Trp Pro Pro Arg Gly Ser Lys Asp 
145                 150                 155                 160 


Phe Ser Thr His Glu Ile Phe Arg Met Glu Gln Leu Leu Thr Trp Lys 
                165                 170                 175     


Gly Thr Cys Gly His Arg Asp Pro Gly Asn Lys Ala Gly Met Thr Ser 
            180                 185                 190         


Leu Pro Gly Gly Pro Gln Ser Arg Gly Arg Arg Glu Ala Arg Arg Thr 
        195                 200                 205             


Arg Lys Tyr Leu Glu Leu Tyr Ile Val Ala Asp His Thr Leu Phe Leu 
    210                 215                 220                 


Thr Arg His Arg Asn Leu Asn His Thr Lys Gln Arg Leu Leu Glu Val 
225                 230                 235                 240 


Ala Asn Tyr Val Asp Gln Leu Leu Arg Thr Leu Asp Ile Gln Val Ala 
                245                 250                 255     


Leu Thr Gly Leu Glu Val Trp Thr Glu Arg Asp Arg Ser Arg Val Thr 
            260                 265                 270         


Gln Asp Ala Asn Ala Thr Leu Trp Ala Phe Leu Gln Trp Arg Arg Gly 
        275                 280                 285             


Leu Trp Ala Gln Arg Pro His Asp Ser Ala Gln Leu Leu Thr Gly Arg 
    290                 295                 300                 


Ala Phe Gln Gly Ala Thr Val Gly Leu Ala Pro Val Glu Gly Met Cys 
305                 310                 315                 320 


Arg Ala Glu Ser Ser Gly Gly Val Ser Thr Asp His Ser Glu Leu Pro 
                325                 330                 335     


Ile Gly Ala Ala Ala Thr Met Ala His Glu Ile Gly His Ser Leu Gly 
            340                 345                 350         


Leu Ser His Asp Pro Asp Gly Cys Cys Val Glu Ala Ala Ala Glu Ser 
        355                 360                 365             


Gly Gly Cys Val Met Ala Ala Ala Thr Gly His Pro Phe Pro Arg Val 
    370                 375                 380                 


Phe Ser Ala Cys Ser Arg Arg Gln Leu Arg Ala Phe Phe Arg Lys Gly 
385                 390                 395                 400 


Gly Gly Ala Cys Leu Ser Asn Ala Pro Asp Pro Gly Leu Pro Val Pro 
                405                 410                 415     


Pro Ala Leu Cys Gly Asn Gly Phe Val Glu Ala Gly Glu Glu Cys Asp 
            420                 425                 430         


Cys Gly Pro Gly Gln Glu Cys Arg Asp Leu Cys Cys Phe Ala His Asn 
        435                 440                 445             


Cys Ser Leu Arg Pro Gly Ala Gln Cys Ala His Gly Asp Cys Cys Val 
    450                 455                 460                 


Arg Cys Leu Leu Lys Pro Ala Gly Ala Leu Cys Arg Gln Ala Met Gly 
465                 470                 475                 480 


Asp Cys Asp Leu Pro Glu Phe Cys Thr Gly Thr Ser Ser His Cys Pro 
                485                 490                 495     


Pro Asp Val Tyr Leu Leu Asp Gly Ser Pro Cys Ala Arg Gly Ser Gly 
            500                 505                 510         


Tyr Cys Trp Asp Gly Ala Cys Pro Thr Leu Glu Gln Gln Cys Gln Gln 
        515                 520                 525             


Leu Trp Gly Pro Gly Ser His Pro Ala Pro Glu Ala Cys Phe Gln Val 
    530                 535                 540                 


Val Asn Ser Ala Gly Asp Ala His Gly Asn Cys Gly Gln Asp Ser Glu 
545                 550                 555                 560 


Gly His Phe Leu Pro Cys Ala Gly Arg Asp Ala Leu Cys Gly Lys Leu 
                565                 570                 575     


Gln Cys Gln Gly Gly Lys Pro Ser Leu Leu Ala Pro His Met Val Pro 
            580                 585                 590         


Val Asp Ser Thr Val His Leu Asp Gly Gln Glu Val Thr Cys Arg Gly 
        595                 600                 605             


Ala Leu Ala Leu Pro Ser Ala Gln Leu Asp Leu Leu Gly Leu Gly Leu 
    610                 615                 620                 


Val Glu Pro Gly Thr Gln Cys Gly Pro Arg Met Val Cys Asn Ser Asn 
625                 630                 635                 640 


His Asn Cys His Cys Ala Pro Gly Trp Ala Pro Pro Phe Cys Asp Lys 
                645                 650                 655     


Pro Gly Phe Gly Gly Ser Met Asp Ser Gly Pro Val Gln Ala Glu Asn 
            660                 665                 670         


His Asp Thr Phe Leu Leu Ala Met Leu Leu Ser Val Leu Leu Pro Leu 
        675                 680                 685             


Leu Pro Gly Ala Gly Leu Ala Trp Cys Cys Tyr Arg Leu Pro Gly Ala 
    690                 695                 700                 


His Leu Gln Arg Cys Ser Trp Gly Cys Arg Arg Asp Pro Ala Cys Ser 
705                 710                 715                 720 


Gly Pro Lys Asp Gly Pro His Arg Asp His Pro Leu Gly Gly Val His 
                725                 730                 735     


Pro Met Glu Leu Gly Pro Thr Ala Thr Gly Gln Pro Trp Pro Leu Asp 
            740                 745                 750         


Pro Glu Asn Ser His Glu Pro Ser Ser His Pro Glu Lys Pro Leu Pro 
        755                 760                 765             


Ala Val Ser Pro Asp Pro Gln Ala Asp Gln Val Gln Met Pro Arg Ser 
    770                 775                 780                 


Cys Leu Trp 
785         


<210>  6158
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  6158

Met Val Ser Gly Asp Tyr Ser Leu Gly Leu Asn Asp Leu Asn Val Ser 
1               5                   10                  15      


Pro Pro Glu Leu Thr Val His Val Gly Asp Ser Ala Leu Met Gly Cys 
            20                  25                  30          


Val Phe Gln Ser Thr Glu Asp Lys Cys Ile Phe Lys Ile Asp Trp Thr 
        35                  40                  45              


Leu Ser Pro Gly Glu His Ala Lys Asp Glu Tyr Val Leu Tyr Tyr Tyr 
    50                  55                  60                  


Ser Asn Leu Ser Val Pro Ile Gly Arg Phe Gln Asn Arg Val His Leu 
65                  70                  75                  80  


Met Gly Asp Ile Leu Cys Asn Asp Gly Ser Leu Leu Leu Gln Asp Val 
                85                  90                  95      


Gln Glu Ala Asp Gln Gly Thr Tyr Ile Cys Glu Ile Arg Leu Lys Gly 
            100                 105                 110         


Glu Ser Gln Val Phe Lys Lys Ala Val Val Leu His Val Leu Pro Glu 
        115                 120                 125             


Glu Pro Lys Glu Leu Met Val His Val Gly Gly Leu Ile Gln Met Gly 
    130                 135                 140                 


Cys Val Phe Gln Ser Thr Glu Val Lys His Val Thr Lys Val Glu Trp 
145                 150                 155                 160 


Ile Phe Ser Gly Arg Arg Ala Lys Glu Glu Ile Val Phe Arg Tyr Tyr 
                165                 170                 175     


His Lys Leu Arg Met Ser Val Glu Tyr Ser Gln Ser Trp Gly His Phe 
            180                 185                 190         


Gln Asn Arg Val Asn Leu Val Gly Asp Ile Phe Arg Asn Asp Gly Ser 
        195                 200                 205             


Ile Met Leu Gln Gly Val Arg Glu Ser Asp Gly Gly Asn Tyr Thr Cys 
    210                 215                 220                 


Ser Ile His Leu Gly Asn Leu Val Phe Lys Lys Thr Ile Val Leu His 
225                 230                 235                 240 


Val Ser Pro Glu Glu Pro Arg Thr Leu Val Thr Pro Ala Ala Leu Arg 
                245                 250                 255     


Pro Leu Val Leu Gly Gly Asn Gln Leu Val Ile Ile Val Gly Ile Val 
            260                 265                 270         


Cys Ala Thr Ile Leu Leu Leu Pro Val Leu Ile Leu Ile Val Lys Lys 
        275                 280                 285             


Thr Cys Gly Asn Lys Ser Ser Val Asn Ser Thr Val Leu Val Lys Asn 
    290                 295                 300                 


Thr Lys Lys Thr Asn Pro Glu Ile Lys Glu Lys Pro Cys His Phe Glu 
305                 310                 315                 320 


Arg Cys Glu Gly Glu Lys His Ile Tyr Ser Pro Ile Ile Val Arg Glu 
                325                 330                 335     


Val Ile Glu Glu Glu Glu Pro Ser Glu Lys Ser Glu Ala Thr Tyr Met 
            340                 345                 350         


Thr Met His Pro Val Trp Pro Ser Leu Arg Ser Asp Arg Asn Asn Ser 
        355                 360                 365             


Leu Glu Lys Lys Ser Gly Gly Gly Met Pro Lys Thr Gln Gln Ala Phe 
    370                 375                 380                 


<210>  6159
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  6159

Met Asn Trp Ala Phe Leu Gln Gly Leu Leu Ser Gly Val Asn Lys Tyr 
1               5                   10                  15      


Ser Thr Val Leu Ser Arg Ile Trp Leu Ser Val Val Phe Ile Phe Arg 
            20                  25                  30          


Val Leu Val Tyr Val Val Ala Ala Glu Glu Val Trp Asp Asp Glu Gln 
        35                  40                  45              


Lys Asp Phe Val Cys Asn Thr Lys Gln Pro Gly Cys Pro Asn Val Cys 
    50                  55                  60                  


Tyr Asp Glu Phe Phe Pro Val Ser His Val Arg Leu Trp Ala Leu Gln 
65                  70                  75                  80  


Leu Ile Leu Val Thr Cys Pro Ser Leu Leu Val Val Met His Val Ala 
                85                  90                  95      


Tyr Arg Glu Glu Arg Glu Arg Lys His His Leu Lys His Gly Pro Asn 
            100                 105                 110         


Ala Pro Ser Leu Tyr Asp Asn Leu Ser Lys Lys Arg Gly Gly Leu Trp 
        115                 120                 125             


Trp Thr Tyr Leu Leu Ser Leu Ile Phe Lys Ala Ala Val Asp Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Ile Phe His Arg Leu Tyr Lys Asp Tyr Asp Met Pro Arg 
145                 150                 155                 160 


Val Val Ala Cys Ser Val Glu Pro Cys Pro His Thr Val Asp Cys Tyr 
                165                 170                 175     


Ile Ser Arg Pro Thr Glu Lys Lys Val Phe Thr Tyr Phe Met Val Thr 
            180                 185                 190         


Thr Ala Ala Ile Cys Ile Leu Leu Asn Leu Ser Glu Val Phe Tyr Leu 
        195                 200                 205             


Val Gly Lys Arg Cys Met Glu Ile Phe Gly Pro Arg His Arg Arg Pro 
    210                 215                 220                 


Arg Cys Arg Glu Cys Leu Pro Asp Thr Cys Pro Pro Tyr Val Leu Ser 
225                 230                 235                 240 


Gln Gly Gly His Pro Glu Asp Gly Asn Ser Val Leu Met Lys Ala Gly 
                245                 250                 255     


Ser Ala Pro Val Asp Ala Gly Gly Tyr Pro 
            260                 265     


<210>  6160
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  6160

Met Pro Ser Leu Ala Pro Asp Cys Pro Leu Leu Ala Met Pro Glu Glu 
1               5                   10                  15      


Thr Gln Glu Asp Ser Val Ala Pro Met Met Pro Ser Gln Arg Ser Arg 
            20                  25                  30          


Gly Pro Leu Ala Pro Asn His Val His Glu Val Cys Leu His Gln Val 
        35                  40                  45              


Glu Ser Ile Ser Asp Leu His Ser Gly Ala Gly Thr Leu Arg Pro Tyr 
    50                  55                  60                  


Leu Thr Glu Glu Ala Arg Pro Trp Asp Glu Leu Leu Gly Val Leu Pro 
65                  70                  75                  80  


Pro Ser Leu Cys Ala Gln Ala Gly Cys Ser Pro Val Tyr Arg Arg Gly 
                85                  90                  95      


Gly Phe Leu Leu Leu Leu Ala Leu Leu Val Leu Thr Cys Leu Val Leu 
            100                 105                 110         


Ala Leu Leu Ala Val Tyr Leu Ser Val Leu Gln Ser Glu Ser Leu Arg 
        115                 120                 125             


Ile Leu Ala His Thr Leu Arg Thr Gln Glu Glu Thr Leu Leu Lys Leu 
    130                 135                 140                 


Arg Leu Ala Ser Leu Ser Gln Leu Arg Arg Leu Asn Ser Ser Glu Ala 
145                 150                 155                 160 


Gln Ala Pro Ser 
                


<210>  6161
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  6161

Met Glu Gln Gly Ser Gly Arg Leu Glu Asp Phe Pro Val Asn Val Phe 
1               5                   10                  15      


Ser Val Thr Pro Tyr Thr Pro Ser Thr Ala Asp Ile Gln Val Ser Asp 
            20                  25                  30          


Asp Asp Lys Ala Gly Ala Thr Leu Leu Phe Ser Gly Ile Phe Leu Gly 
        35                  40                  45              


Leu Val Gly Ile Thr Phe Thr Val Met Gly Trp Ile Lys Tyr Gln Gly 
    50                  55                  60                  


Val Ser His Phe Glu Trp Thr Gln Leu Leu Gly Pro Val Leu Leu Ser 
65                  70                  75                  80  


Val Gly Val Thr Phe Ile Leu Ile Ala Val Cys Lys Phe Lys Met Leu 
                85                  90                  95      


Ser Cys Gln Leu Cys Lys Glu Ser Glu Glu Arg Val Pro Asp Ser Glu 
            100                 105                 110         


Gln Thr Pro Gly Gly Pro Ser Phe Val Phe Thr Gly Ile Asn Gln Pro 
        115                 120                 125             


Ile Thr Phe His Gly Ala Thr Val Val Gln Tyr Ile Pro Pro Pro Tyr 
    130                 135                 140                 


Gly Ser Pro Glu Pro Met Gly Ile Asn Thr Ser Tyr Leu Gln Ser Val 
145                 150                 155                 160 


Val Ser Pro Cys Gly Leu Ile Thr Ser Gly Gly Ala Ala Ala Ala Met 
                165                 170                 175     


Ser Ser Pro Pro Gln Tyr Tyr Thr Ile Tyr Pro Gln Asp Asn Ser Ala 
            180                 185                 190         


Phe Val Val Asp Glu Gly Cys Leu Ser Phe Thr Asp Gly Gly Asn His 
        195                 200                 205             


Arg Pro Asn Pro Asp Val Asp Gln Leu Glu Glu Thr Gln Leu Glu Glu 
    210                 215                 220                 


Glu Ala Cys Ala Cys Phe Ser Pro Pro Pro Tyr Glu Glu Ile Tyr Ser 
225                 230                 235                 240 


Leu Pro Arg 
            


<210>  6162
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  6162

Met Arg Pro Gln Asp Ser Thr Gly Val Ala Glu Leu Gln Glu Pro Gly 
1               5                   10                  15      


Leu Pro Leu Thr Asp Asp Ala Pro Pro Gly Ala Thr Glu Glu Pro Ala 
            20                  25                  30          


Ala Ala Glu Ala Ala Gly Ala Pro Asp Arg Gly Arg Cys Trp Leu Cys 
        35                  40                  45              


Leu Ser Ser Pro Cys Cys Ser Arg Thr Glu Pro Ala Lys Lys Lys Ala 
    50                  55                  60                  


Pro Cys Pro Gly Leu Gly Leu Phe Tyr Thr Leu Leu Ser Ala Phe Leu 
65                  70                  75                  80  


Phe Ser Val Gly Ser Leu Phe Val Lys Lys Val Gln Asp Val His Ala 
                85                  90                  95      


Val Glu Ile Ser Ala Phe Arg Cys Val Phe Gln Met Leu Val Val Ile 
            100                 105                 110         


Pro Cys Leu Ile Tyr Arg Lys Thr Gly Phe Ile Gly Pro Lys Gly Gln 
        115                 120                 125             


Arg Ile Phe Leu Ile Leu Arg Gly Val Leu Gly Ser Thr Ala Met Met 
    130                 135                 140                 


Leu Ile Tyr Tyr Ala Tyr Gln Thr Met Ser Leu Ala Asp Ala Thr Val 
145                 150                 155                 160 


Ile Thr Phe Ser Ser Pro Val Phe Thr Ser Ile Phe Ala Trp Ile Cys 
                165                 170                 175     


Leu Lys Glu Lys Tyr Ser Pro Trp Asp Ala Leu Phe Thr Val Phe Thr 
            180                 185                 190         


Ile Thr Gly Val Ile Leu Ile Val Arg Pro Pro Phe Leu Phe Gly Ser 
        195                 200                 205             


Asp Thr Ser Gly Met Glu Glu Ser Tyr Ser Gly His Leu Lys Gly Thr 
    210                 215                 220                 


Phe Ala Ala Ile Gly Ser Ala Val Phe Ala Ala Ser Thr Leu Val Ile 
225                 230                 235                 240 


Leu Arg Lys Met Gly Lys Ser Val Asp Tyr Phe Leu Ser Ile Trp Tyr 
                245                 250                 255     


Tyr Val Val Leu Gly Leu Val Glu Ser Val Ile Ile Leu Ser Val Leu 
            260                 265                 270         


Gly Glu Trp Ser Leu Pro Tyr Cys Gly Leu Asp Arg Leu Phe Leu Ile 
        275                 280                 285             


Phe Ile Gly Leu Phe Gly Leu Gly Gly Gln Ile Phe Ile Thr Lys Ala 
    290                 295                 300                 


Leu Gln Ile Glu Lys Ala Gly Pro Val Ala Ile Met Lys Thr Met Asp 
305                 310                 315                 320 


Val Val Phe Ala Phe Ile Phe Gln Ile Ile Phe Phe Asn Asn Val Pro 
                325                 330                 335     


Thr Trp Trp Thr Val Gly Gly Ala Leu Cys Val Val Ala Ser Asn Val 
            340                 345                 350         


Gly Ala Ala Ile Arg Lys Trp Tyr Gln Ser Ser Lys 
        355                 360                 


<210>  6163
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  6163

Met Ser Gln Ala Trp Val Pro Gly Leu Ala Pro Thr Leu Leu Phe Ser 
1               5                   10                  15      


Leu Leu Ala Gly Pro Gln Lys Ile Ala Ala Lys Cys Gly Leu Ile Leu 
            20                  25                  30          


Ala Cys Pro Lys Gly Phe Lys Cys Cys Gly Asp Ser Cys Cys Gln Glu 
        35                  40                  45              


Asn Glu Leu Phe Pro Gly Pro Val Arg Ile Phe Val Ile Ile Phe Leu 
    50                  55                  60                  


Val Ile Leu Ser Val Phe Cys Ile Cys Gly Leu Ala Lys Cys Phe Cys 
65                  70                  75                  80  


Arg Asn Cys Arg Glu Pro Glu Pro Asp Ser Pro Val Asp Cys Arg Gly 
                85                  90                  95      


Pro Leu Glu Leu Pro Ser Ile Ile Pro Pro Glu Arg Val Arg Val Ser 
            100                 105                 110         


Leu Ser Ala Pro Pro Pro Pro Tyr Ser Glu Val Ile Leu Lys Pro Ser 
        115                 120                 125             


Leu Gly Pro Thr Pro Thr Glu Pro Pro Pro Pro Tyr Ser Phe Arg Pro 
    130                 135                 140                 


Glu Glu Tyr Thr Gly Asp Gln Arg Gly Ile Asp Asn Pro Ala Phe 
145                 150                 155                 


<210>  6164
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  6164

Met Gln Asn Arg Thr Gly Leu Ile Leu Cys Ala Leu Ala Leu Leu Met 
1               5                   10                  15      


Gly Phe Leu Met Val Cys Leu Gly Ala Phe Phe Ile Ser Trp Gly Ser 
            20                  25                  30          


Ile Phe Asp Cys Gln Gly Ser Leu Ile Ala Ala Tyr Leu Leu Leu Pro 
        35                  40                  45              


Leu Gly Phe Val Ile Leu Leu Ser Gly Ile Phe Trp Ser Asn Tyr Arg 
    50                  55                  60                  


Gln Val Thr Glu Ser Lys Gly Val Leu Arg His Met Leu Arg Gln His 
65                  70                  75                  80  


Leu Ala His Gly Ala Leu Pro Val Ala Thr Val Asp Arg Pro Asp Phe 
                85                  90                  95      


Tyr Pro Pro Ala Tyr Glu Glu Ser Leu Glu Val Glu Lys Gln Ser Cys 
            100                 105                 110         


Pro Ala Glu Arg Glu Ala Ser Gly Ile Pro Pro Pro Leu Tyr Thr Glu 
        115                 120                 125             


Thr Gly Leu Glu Phe Gln Asp Gly Asn Asp Ser His Pro Glu Ala Pro 
    130                 135                 140                 


Pro Ser Tyr Arg Glu Ser Ile Ala Gly Leu Val Val Thr Ala Ile Ser 
145                 150                 155                 160 


Glu Asp Ala Gln Arg Arg Gly Gln Glu Cys 
                165                 170 


<210>  6165
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  6165

Met Gly Ser Val Gly Ser Gln Arg Leu Glu Glu Pro Ser Val Ala Gly 
1               5                   10                  15      


Thr Pro Asp Pro Gly Val Val Met Ser Phe Thr Phe Asp Ser His Gln 
            20                  25                  30          


Leu Glu Glu Ala Ala Glu Ala Ala Gln Gly Gln Gly Leu Arg Ala Arg 
        35                  40                  45              


Gly Val Pro Ala Phe Thr Asp Thr Thr Leu Asp Glu Pro Val Pro Asp 
    50                  55                  60                  


Asp Arg Tyr His Ala Ile Tyr Phe Ala Met Leu Leu Ala Gly Val Gly 
65                  70                  75                  80  


Phe Leu Leu Pro Tyr Asn Ser Phe Ile Thr Asp Val Asp Tyr Leu His 
                85                  90                  95      


His Lys Tyr Pro Gly Thr Ser Ile Val Phe Asp Met Ser Leu Thr Tyr 
            100                 105                 110         


Ile Leu Val Ala Leu Ala Ala Val Leu Leu Asn Asn Val Leu Val Glu 
        115                 120                 125             


Arg Leu Thr Leu His Thr Arg Ile Thr Ala Gly Tyr Leu Leu Ala Leu 
    130                 135                 140                 


Gly Pro Leu Leu Phe Ile Ser Ile Cys Asp Val Trp Leu Gln Leu Phe 
145                 150                 155                 160 


Ser Arg Asp Gln Ala Tyr Ala Ile Asn Leu Ala Ala Val Gly Thr Val 
                165                 170                 175     


Ala Phe Gly Cys Thr Val Gln Gln Ser Ser Phe Tyr Gly Tyr Thr Gly 
            180                 185                 190         


Met Leu Pro Lys Arg Tyr Thr Gln Gly Val Met Thr Gly Glu Ser Thr 
        195                 200                 205             


Ala Gly Val Met Ile Ser Leu Ser Arg Ile Leu Thr Lys Leu Leu Leu 
    210                 215                 220                 


Pro Asp Glu Arg Ala Ser Thr Leu Ile Phe Phe Leu Val Ser Val Ala 
225                 230                 235                 240 


Leu Glu Leu Leu Cys Phe Leu Leu His Leu Leu Val Arg Arg Ser Arg 
                245                 250                 255     


Phe Val Leu Phe Tyr Thr Thr Arg Pro Arg Asp Ser His Arg Gly Arg 
            260                 265                 270         


Pro Gly Leu Gly Arg Gly Tyr Gly Tyr Arg Val His His Asp Val Val 
        275                 280                 285             


Ala Gly Asp Val His Phe Glu His Pro Ala Pro Ala Leu Ala Pro Asn 
    290                 295                 300                 


Glu Ser Pro Lys Asp Ser Pro Ala His Glu Val Thr Gly Ser Gly Gly 
305                 310                 315                 320 


Ala Tyr Met Arg Phe Asp Val Pro Arg Pro Arg Val Gln Arg Ser Trp 
                325                 330                 335     


Pro Thr Phe Arg Ala Leu Leu Leu His Arg Tyr Val Val Ala Arg Val 
            340                 345                 350         


Ile Trp Ala Asp Met Leu Ser Ile Ala Val Thr Tyr Phe Ile Thr Leu 
        355                 360                 365             


Cys Leu Phe Pro Gly Leu Glu Ser Glu Ile Arg His Cys Ile Leu Gly 
    370                 375                 380                 


Glu Trp Leu Pro Ile Leu Ile Met Ala Val Phe Asn Leu Ser Asp Phe 
385                 390                 395                 400 


Val Gly Lys Ile Leu Ala Ala Leu Pro Val Asp Trp Arg Gly Thr His 
                405                 410                 415     


Leu Leu Ala Cys Ser Cys Leu Arg Val Val Phe Ile Pro Leu Phe Ile 
            420                 425                 430         


Leu Cys Val Tyr Pro Ser Gly Met Pro Ala Leu Arg His Pro Ala Trp 
        435                 440                 445             


Pro Cys Ile Phe Ser Leu Leu Met Gly Ile Ser Asn Gly Tyr Phe Gly 
    450                 455                 460                 


Ser Val Pro Met Ile Leu Ala Ala Gly Lys Val Ser Pro Lys Gln Arg 
465                 470                 475                 480 


Glu Leu Ala Gly Asn Thr Met Thr Val Ser Tyr Met Ser Gly Leu Thr 
                485                 490                 495     


Leu Gly Ser Ala Val Ala Tyr Cys Thr Tyr Ser Leu Thr Arg Asp Ala 
            500                 505                 510         


His Gly Ser Cys Leu His Ala Ser Thr Ala Asn Gly Ser Ile Leu Ala 
        515                 520                 525             


Gly Leu 
    530 


<210>  6166
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  6166

Met Ala Pro Trp Thr Leu Trp Arg Cys Cys Gln Arg Val Val Gly Trp 
1               5                   10                  15      


Val Pro Val Leu Phe Ile Thr Phe Val Val Val Trp Ser Tyr Tyr Ala 
            20                  25                  30          


Tyr Val Val Glu Leu Cys Val Phe Thr Ile Phe Gly Asn Glu Glu Asn 
        35                  40                  45              


Gly Lys Thr Val Val Tyr Leu Val Ala Phe His Leu Phe Phe Val Met 
    50                  55                  60                  


Phe Val Trp Ser Tyr Trp Met Thr Ile Phe Thr Ser Pro Ala Ser Pro 
65                  70                  75                  80  


Ser Lys Glu Phe Tyr Leu Ser Asn Ser Glu Lys Glu Arg Tyr Glu Lys 
                85                  90                  95      


Glu Phe Ser Gln Glu Arg Gln Gln Glu Ile Leu Arg Arg Ala Ala Arg 
            100                 105                 110         


Ala Leu Pro Ile Tyr Thr Thr Ser Ala Ser Lys Thr Ile Arg Tyr Cys 
        115                 120                 125             


Glu Lys Cys Gln Leu Ile Lys Pro Asp Arg Ala His His Cys Ser Ala 
    130                 135                 140                 


Cys Asp Ser Cys Ile Leu Lys Met Asp His His Cys Pro Trp Val Asn 
145                 150                 155                 160 


Asn Cys Val Gly Phe Ser Asn Tyr Lys Phe Phe Leu Leu Phe Leu Leu 
                165                 170                 175     


Tyr Ser Leu Leu Tyr Cys Leu Phe Val Ala Ala Thr Val Leu Glu Tyr 
            180                 185                 190         


Phe Ile Lys Phe Trp Thr Asn Glu Leu Thr Asp Thr Arg Ala Lys Phe 
        195                 200                 205             


His Val Leu Phe Leu Phe Phe Val Ser Ala Met Phe Phe Ile Ser Val 
    210                 215                 220                 


Leu Ser Leu Phe Ser Tyr His Cys Trp Leu Val Gly Lys Asn Arg Thr 
225                 230                 235                 240 


Thr Ile Glu Ser Phe Arg Ala Pro Thr Phe Ser Tyr Gly Pro Asp Gly 
                245                 250                 255     


Asn Gly Phe Ser Leu Gly Cys Ser Lys Asn Trp Arg Gln Val Phe Gly 
            260                 265                 270         


Asp Glu Lys Lys Tyr Trp Leu Leu Pro Ile Phe Ser Ser Leu Gly Asp 
        275                 280                 285             


Gly Cys Ser Phe Pro Thr Arg Leu Val Gly Met Asp Pro Glu Gln Ala 
    290                 295                 300                 


Ser Val Thr Asn Gln Asn Glu Tyr Ala Arg Ser Gly Ser Asn Gln Pro 
305                 310                 315                 320 


Phe Pro Ile Lys Pro Leu Ser Glu Ser Lys Asn Arg Leu Leu Asp Ser 
                325                 330                 335     


Glu Ser Gln Trp Leu Glu Asn Gly Ala Glu Glu Gly Ile Val Lys Ser 
            340                 345                 350         


Gly Val 
        


<210>  6167
<211>  566
<212>  PRT
<213>  Homo sapiens

<400>  6167

Met Ala Arg Gln Pro Tyr Arg Phe Pro Gln Ala Arg Ile Pro Glu Arg 
1               5                   10                  15      


Gly Ser Gly Val Phe Arg Leu Thr Val Arg Asn Ala Met Ala His Arg 
            20                  25                  30          


Asp Ser Glu Met Lys Glu Glu Cys Leu Arg Glu Asp Leu Lys Phe Tyr 
        35                  40                  45              


Phe Met Ser Pro Cys Glu Lys Tyr Arg Ala Arg Arg Gln Ile Pro Trp 
    50                  55                  60                  


Lys Leu Gly Leu Gln Ile Leu Lys Ile Val Met Val Thr Thr Gln Leu 
65                  70                  75                  80  


Val Arg Phe Gly Leu Ser Asn Gln Leu Val Val Ala Phe Lys Glu Asp 
                85                  90                  95      


Asn Thr Val Ala Phe Lys His Leu Phe Leu Lys Gly Tyr Ser Gly Thr 
            100                 105                 110         


Asp Glu Asp Asp Tyr Ser Cys Ser Val Tyr Thr Gln Glu Asp Ala Tyr 
        115                 120                 125             


Glu Ser Ile Phe Phe Ala Ile Asn Gln Tyr His Gln Leu Lys Asp Ile 
    130                 135                 140                 


Thr Leu Gly Thr Leu Gly Tyr Gly Glu Asn Glu Asp Asn Arg Ile Gly 
145                 150                 155                 160 


Leu Lys Val Cys Lys Gln His Tyr Lys Lys Gly Thr Met Phe Pro Ser 
                165                 170                 175     


Asn Glu Thr Leu Asn Ile Asp Asn Asp Val Glu Leu Asp Cys Val Gln 
            180                 185                 190         


Leu Asp Leu Gln Asp Leu Ser Lys Lys Pro Pro Asp Trp Lys Asn Ser 
        195                 200                 205             


Ser Phe Phe Arg Leu Glu Phe Tyr Arg Leu Leu Gln Val Glu Ile Ser 
    210                 215                 220                 


Phe His Leu Lys Gly Ile Asp Leu Gln Thr Ile His Ser Arg Glu Leu 
225                 230                 235                 240 


Pro Asp Cys Tyr Val Phe Gln Asn Thr Ile Ile Phe Asp Asn Lys Ala 
                245                 250                 255     


His Ser Gly Lys Ile Lys Ile Tyr Phe Asp Ser Asp Ala Lys Ile Glu 
            260                 265                 270         


Glu Cys Lys Asp Leu Asn Ile Phe Gly Ser Thr Gln Lys Asn Ala Gln 
        275                 280                 285             


Tyr Val Leu Val Phe Asp Ala Phe Val Ile Val Ile Cys Leu Ala Ser 
    290                 295                 300                 


Leu Ile Leu Cys Thr Arg Ser Ile Val Leu Ala Leu Arg Leu Arg Lys 
305                 310                 315                 320 


Arg Phe Leu Asn Phe Phe Leu Glu Lys Tyr Lys Arg Pro Val Cys Asp 
                325                 330                 335     


Thr Asp Gln Trp Glu Phe Ile Asn Gly Trp Tyr Val Leu Val Ile Ile 
            340                 345                 350         


Ser Asp Leu Met Thr Ile Ile Gly Ser Ile Leu Lys Met Glu Ile Lys 
        355                 360                 365             


Ala Lys Asn Leu Thr Asn Tyr Asp Leu Cys Ser Ile Phe Leu Gly Thr 
    370                 375                 380                 


Ser Thr Leu Leu Val Trp Val Gly Val Ile Arg Tyr Leu Gly Tyr Phe 
385                 390                 395                 400 


Gln Ala Tyr Asn Val Leu Ile Leu Thr Met Gln Ala Ser Leu Pro Lys 
                405                 410                 415     


Val Leu Arg Phe Cys Ala Cys Ala Gly Met Ile Tyr Leu Gly Tyr Thr 
            420                 425                 430         


Phe Cys Gly Trp Ile Val Leu Gly Pro Tyr His Asp Lys Phe Glu Asn 
        435                 440                 445             


Leu Asn Thr Val Ala Glu Cys Leu Phe Ser Leu Val Asn Gly Asp Asp 
    450                 455                 460                 


Met Phe Ala Thr Phe Ala Gln Ile Gln Gln Lys Ser Ile Leu Val Trp 
465                 470                 475                 480 


Leu Phe Ser Arg Leu Tyr Leu Tyr Ser Phe Ile Ser Leu Phe Ile Tyr 
                485                 490                 495     


Met Ile Leu Ser Leu Phe Ile Ala Leu Ile Thr Asp Ser Tyr Asp Thr 
            500                 505                 510         


Ile Lys Lys Phe Gln Gln Asn Gly Phe Pro Glu Thr Asp Leu Gln Glu 
        515                 520                 525             


Phe Leu Lys Glu Cys Ser Ser Lys Glu Glu Tyr Gln Lys Glu Ser Ser 
    530                 535                 540                 


Ala Phe Leu Ser Cys Ile Cys Cys Arg Arg Arg Lys Arg Ser Asp Asp 
545                 550                 555                 560 


His Leu Ile Pro Ile Ser 
                565     


<210>  6168
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  6168

Met Asn Ser Leu Glu Gln Ala Glu Ala Pro Arg Val Val Ser Leu Ile 
1               5                   10                  15      


Pro Ala Val Val Ser Gly Asn Cys Gln Asp Leu Lys Ala Phe Glu Arg 
            20                  25                  30          


Arg Leu Thr Glu Tyr Ile His Cys Leu Gln Pro Ala Thr Gly Arg Trp 
        35                  40                  45              


Arg Met Leu Leu Ile Val Val Ser Val Cys Thr Ala Thr Gly Ala Trp 
    50                  55                  60                  


Asn Trp Leu Ile Asp Pro Glu Thr Gln Lys Val Ser Phe Phe Thr Ser 
65                  70                  75                  80  


Leu Trp Asn His Pro Phe Phe Thr Ile Ser Cys Ile Thr Leu Ile Gly 
                85                  90                  95      


Leu Phe Phe Ala Gly Ile His Lys Arg Val Val Ala Pro Ser Ile Ile 
            100                 105                 110         


Ala Ala Arg Cys Arg Thr Val Leu Ala Glu Tyr Asn Met Ser Cys Asp 
        115                 120                 125             


Asp Thr Gly Lys Leu Ile Leu Lys Pro Arg Pro His Val Gln 
    130                 135                 140         


<210>  6169
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  6169

Met Ala Ile Glu Gly Gly Glu Arg Thr Cys Gly Val His Glu Leu Ile 
1               5                   10                  15      


Cys Ile Arg Lys Val Ser Pro Glu Ala Val Gly Phe Leu Ser Ala Val 
            20                  25                  30          


Gly Val Phe Ile Ile Leu Met Leu Leu Leu Phe Leu Tyr Ile Asn Lys 
        35                  40                  45              


Lys Phe Cys Phe Glu Asn Val Gly Gly Phe Pro Asp Leu Gly Ser Glu 
    50                  55                  60                  


Tyr Ser Thr Arg Lys Asn Ser Gln Asp Lys Ile Tyr Asn Ser Tyr Met 
65                  70                  75                  80  


Asp Lys Asp Glu His Gly Ser Ser Ser Glu Ser Glu Asp Glu Ala Leu 
                85                  90                  95      


Gly Lys Tyr His Glu Ala Leu Ser Arg Thr His Asn Ser Arg Leu Pro 
            100                 105                 110         


Leu Ala Asp Ser Arg Gln Arg Asn Tyr Ala Trp Glu Thr Arg Gln Lys 
        115                 120                 125             


Tyr Ser Pro Leu Ser Ala Glu Tyr Asp Gly Tyr Ser Ser Glu Ala Ser 
    130                 135                 140                 


Ile Asp Glu Gly Asn Cys Ile Gln Arg Met Arg Arg Thr Pro Pro Leu 
145                 150                 155                 160 


Asp Glu Leu Gln Pro Pro Pro Tyr Gln Asp Asp Ser Gly Ser Pro His 
                165                 170                 175     


Leu Ser Cys Thr Pro Ser Glu Ile Gly Asp Ser Lys Cys Glu Phe Ser 
            180                 185                 190         


His Cys Ser Asn Ser Pro Arg Cys Ser Tyr Asn Lys Cys Pro Ser Glu 
        195                 200                 205             


Gly Ser Thr Gly His Glu Ile Glu Ser Phe His Asn Lys Gly Tyr Glu 
    210                 215                 220                 


Glu Asp Val Pro Ser Asp Ser Thr Ala Val Leu Ser Pro Glu Asp Met 
225                 230                 235                 240 


Ser Ala Gln Gly Ser Ser Ser Gln Leu Pro Lys Pro Phe Asp Pro Glu 
                245                 250                 255     


Pro Glu Ala Lys Tyr Gly Thr Leu Asp Val Thr Phe Asp Tyr Asp Ser 
            260                 265                 270         


Gln Glu Gln Lys Leu Leu Val Thr Val Thr Ala Val Thr Asp Ile Pro 
        275                 280                 285             


Thr Tyr Asn Arg Thr Gly Gly Asn Ser Trp Gln Val His Leu Val Leu 
    290                 295                 300                 


Leu Pro Ile Lys Lys Gln Arg Ala Lys Thr Ser Ile Gln Arg Gly Pro 
305                 310                 315                 320 


Cys Pro Val Phe Thr Glu Thr Phe Lys Phe Asn His Val Glu Ser Glu 
                325                 330                 335     


Met Ile Gly Asn Tyr Ala Val Arg Phe Arg Leu Tyr Gly Val His Arg 
            340                 345                 350         


Met Lys Lys Glu Lys Ile Val Gly Glu Lys Ile Phe Tyr Leu Thr Lys 
        355                 360                 365             


Leu Asn Leu Gln Gly Lys Met Ser Leu Pro Val Ile Leu Glu Pro Ser 
    370                 375                 380                 


Tyr Asn His Ser Gly Cys Asp Ser Gln Met Ser Val Ser Glu Met Ser 
385                 390                 395                 400 


Cys Ser Glu Ser Thr Ser Ser Cys Gln Ser Leu Glu His Gly Ser Val 
                405                 410                 415     


Pro Glu Ile Leu Ile Gly Leu Leu Tyr Asn Ala Thr Thr Gly Arg Leu 
            420                 425                 430         


Ser Ala Glu Val Ile Lys Gly Ser His Phe Lys Asn Leu Ala Ala Asn 
        435                 440                 445             


Arg Pro Pro Asn Thr Tyr Val Lys Leu Thr Leu Leu Asn Ser Met Gly 
    450                 455                 460                 


Gln Glu Met Ser Lys Cys Lys Thr Ser Ile Arg Arg Gly Gln Pro Asn 
465                 470                 475                 480 


Pro Val Tyr Lys Glu Thr Phe Val Phe Gln Val Ala Leu Phe Gln Leu 
                485                 490                 495     


Ser Asp Val Thr Leu Ile Leu Ser Val Tyr Asn Lys Arg Ser Met Lys 
            500                 505                 510         


Arg Lys Glu Met Ile Gly Trp Ile Ser Leu Gly Leu Asn Ser Ser Gly 
        515                 520                 525             


Glu Glu Glu Leu Asn His Trp Thr Glu Met Lys Glu Ser Lys Gly Gln 
    530                 535                 540                 


Gln Val Cys Arg Trp His Ala Leu Leu Glu Ser 
545                 550                 555 


<210>  6170
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  6170

Met Leu Ala Val Arg Lys Ala Arg Arg Lys Leu Arg Met Gly Thr Ile 
1               5                   10                  15      


Cys Ser Pro Asn Pro Ser Gly Thr Lys Thr Ser Ser Glu Val Cys Asn 
            20                  25                  30          


Ala Asp Trp Met Ala Ser Leu Pro Pro His Leu His Asn Leu Pro Leu 
        35                  40                  45              


Ser Asn Leu Ala Ile Pro Gly Ser His Asp Ser Phe Ser Tyr Trp Val 
    50                  55                  60                  


Asp Glu Lys Ser Pro Val Gly Pro Asp Gln Thr Gln Ala Ile Lys Arg 
65                  70                  75                  80  


Leu Ala Arg Ile Ser Leu Val Lys Lys Leu Met Lys Lys Trp Ser Val 
                85                  90                  95      


Thr Gln Asn Leu Thr Phe Arg Glu Gln Leu Glu Ala Gly Ile Arg Tyr 
            100                 105                 110         


Phe Asp Leu Arg Val Ser Ser Lys Pro Gly Asp Ala Asp Gln Glu Ile 
        115                 120                 125             


Tyr Phe Ile His Gly Leu Phe Gly Ile Lys Val Trp Asp Gly Leu Met 
    130                 135                 140                 


Glu Ile Asp Ser Phe Leu Thr Gln His Pro Gln Glu Ile Ile Phe Leu 
145                 150                 155                 160 


Asp Phe Asn His Phe Tyr Ala Met Asp Glu Thr His His Lys Cys Leu 
                165                 170                 175     


Val Leu Arg Ile Gln Glu Ala Phe Gly Asn Lys Leu Cys Pro Ala Cys 
            180                 185                 190         


Ser Val Glu Ser Leu Thr Leu Arg Thr Leu Trp Glu Lys Asn Cys Gln 
        195                 200                 205             


Val Leu Ile Phe Tyr His Cys Pro Phe Tyr Lys Gln Tyr Pro Phe Leu 
    210                 215                 220                 


Trp Pro Gly Lys Lys Ile Pro Ala Pro Trp Ala Asn Thr Thr Ser Val 
225                 230                 235                 240 


Arg Lys Leu Ile Leu Phe Leu Glu Thr Thr Leu Ser Glu Arg Ala Ser 
                245                 250                 255     


Arg Gly Ser Phe His Val Ser Gln Ala Ile Leu Thr Pro Arg Val Lys 
            260                 265                 270         


Thr Ile Ala Arg Gly Leu Val Gly Gly Leu Lys Asn Thr Leu Val His 
        275                 280                 285             


Arg Leu Ala Leu Ile Pro Val Tyr Pro Leu Arg Phe Ser Arg Arg Ser 
    290                 295                 300                 


<210>  6171
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  6171

Met Thr Val Ser Tyr Thr Leu Lys Val Ala Glu Ala Arg Phe Gly Gly 
1               5                   10                  15      


Phe Ser Gly Leu Leu Leu Arg Trp Arg Gly Ser Ile Tyr Lys Leu Leu 
            20                  25                  30          


Tyr Lys Glu Phe Leu Leu Phe Gly Ala Leu Tyr Ala Val Leu Ser Ile 
        35                  40                  45              


Thr Tyr Arg Leu Leu Leu Thr Gln Glu Gln Arg Tyr Val Tyr Ala Gln 
    50                  55                  60                  


Val Ala Arg Tyr Cys Asn Arg Ser Ala Asp Leu Ile Pro Leu Ser Phe 
65                  70                  75                  80  


Val Leu Gly Phe Tyr Val Thr Leu Val Val Asn Arg Trp Trp Ser Gln 
                85                  90                  95      


Tyr Thr Ser Ile Pro Leu Pro Asp Gln Leu Met Cys Val Ile Ser Ala 
            100                 105                 110         


Ser Val His Gly Val Asp Gln Arg Gly Arg Leu Leu Arg Arg Thr Leu 
        115                 120                 125             


Ile Arg Tyr Ala Asn Leu Ala Ser Val Leu Val Leu Arg Ser Val Ser 
    130                 135                 140                 


Thr Arg Val Leu Lys Arg Phe Pro Thr Met Glu His Val Val Asp Ala 
145                 150                 155                 160 


Gly Phe Met Ser Gln Glu Glu Arg Lys Lys Phe Glu Ser Leu Lys Ser 
                165                 170                 175     


Asp Phe Asn Lys Tyr Trp Val Pro Cys Val Trp Phe Thr Asn Leu Ala 
            180                 185                 190         


Ala Gln Ala Arg Arg Asp Gly Arg Ile Arg Asp Asp Ile Ala Leu Cys 
        195                 200                 205             


Leu Leu Leu Glu Glu Leu Asn Lys Tyr Arg Ala Lys Cys Ser Met Leu 
    210                 215                 220                 


Phe His Tyr Asp Trp Ile Ser Ile Pro Leu Val Tyr Thr Gln Val Val 
225                 230                 235                 240 


Thr Ile Ala Val Tyr Ser Phe Phe Ala Leu Ser Leu Val Gly Arg Gln 
                245                 250                 255     


Phe Val Glu Pro Glu Ala Gly Ala Ala Lys Pro Gln Lys Leu Leu Lys 
            260                 265                 270         


Pro Gly Gln Glu Pro Ala Pro Ala Leu Gly Asp Pro Asp Met Tyr Val 
        275                 280                 285             


Pro Leu Thr Thr Leu Leu Gln Phe Phe Phe Tyr Ala Gly Trp Leu Lys 
    290                 295                 300                 


Val Ala Glu Gln Ile Ile Asn Pro Phe Gly Glu Asp Asp Asp Asp Phe 
305                 310                 315                 320 


Glu Thr Asn Gln Leu Ile Asp Arg Asn Leu Gln Val Ser Leu Leu Ser 
                325                 330                 335     


Val Asp Glu Met Tyr Gln Asn Leu Pro Pro Ala Glu Lys Asp Gln Tyr 
            340                 345                 350         


Trp Asp Glu Asp Gln Pro Gln Pro Pro Tyr Thr Val Ala Thr Ala Ala 
        355                 360                 365             


Glu Ser Leu Arg Pro Ser Phe Leu Gly Ser Thr Phe Asn Leu Arg Met 
    370                 375                 380                 


Ser Asp Asp Pro Glu Gln Ser Leu Gln Val Glu Ala Ser Pro Gly Ser 
385                 390                 395                 400 


Gly Arg Pro Ala Pro Ala Ala Gln Thr Pro Leu Leu Gly Arg Phe Leu 
                405                 410                 415     


Gly Val Gly Ala Pro Ser Pro Ala Ile Ser Leu Arg Asn Phe Gly Arg 
            420                 425                 430         


Val Arg Gly Thr Pro Arg Pro Pro His Leu Leu Arg Phe Arg Ala Glu 
        435                 440                 445             


Glu Gly Gly Asp Pro Glu Ala Ala Ala Arg Ile Glu Glu Glu Ser Ala 
    450                 455                 460                 


Glu Ser Gly Asp Glu Ala Leu Glu Pro 
465                 470             


<210>  6172
<211>  550
<212>  PRT
<213>  Homo sapiens

<400>  6172

Met Ala Phe Asn Asp Leu Leu Gln Gln Val Gly Gly Val Gly Arg Phe 
1               5                   10                  15      


Gln Gln Ile Gln Val Thr Leu Val Val Leu Pro Leu Leu Leu Met Ala 
            20                  25                  30          


Ser His Asn Thr Leu Gln Asn Phe Thr Ala Ala Ile Pro Thr His His 
        35                  40                  45              


Cys Arg Pro Pro Ala Asp Ala Asn Leu Ser Lys Asn Gly Gly Leu Glu 
    50                  55                  60                  


Val Trp Leu Pro Arg Asp Arg Gln Gly Gln Pro Glu Ser Cys Leu Arg 
65                  70                  75                  80  


Phe Thr Ser Pro Gln Trp Gly Leu Pro Phe Leu Asn Gly Thr Glu Ala 
                85                  90                  95      


Asn Gly Thr Gly Ala Thr Glu Pro Cys Thr Asp Gly Trp Ile Tyr Asp 
            100                 105                 110         


Asn Ser Thr Phe Pro Ser Thr Ile Val Thr Glu Trp Asp Leu Val Cys 
        115                 120                 125             


Ser His Arg Ala Leu Arg Gln Leu Ala Gln Ser Leu Tyr Met Val Gly 
    130                 135                 140                 


Val Leu Leu Gly Ala Met Val Phe Gly Tyr Leu Ala Asp Arg Leu Gly 
145                 150                 155                 160 


Arg Arg Lys Val Leu Ile Leu Asn Tyr Leu Gln Thr Ala Val Ser Gly 
                165                 170                 175     


Thr Cys Ala Ala Phe Ala Pro Asn Phe Pro Ile Tyr Cys Ala Phe Arg 
            180                 185                 190         


Leu Leu Ser Gly Met Ala Leu Ala Gly Ile Ser Leu Asn Cys Met Thr 
        195                 200                 205             


Leu Asn Val Glu Trp Met Pro Ile His Thr Arg Ala Cys Val Gly Thr 
    210                 215                 220                 


Leu Ile Gly Tyr Val Tyr Ser Leu Gly Gln Phe Leu Leu Ala Gly Val 
225                 230                 235                 240 


Ala Tyr Ala Val Pro His Trp Arg His Leu Gln Leu Leu Val Ser Ala 
                245                 250                 255     


Pro Phe Phe Ala Phe Phe Ile Tyr Ser Trp Phe Phe Ile Glu Ser Ala 
            260                 265                 270         


Arg Trp His Ser Ser Ser Gly Arg Leu Asp Leu Thr Leu Arg Ala Leu 
        275                 280                 285             


Gln Arg Val Ala Arg Ile Asn Gly Lys Arg Glu Glu Gly Ala Lys Leu 
    290                 295                 300                 


Ser Met Glu Val Leu Arg Ala Ser Leu Gln Lys Glu Leu Thr Met Gly 
305                 310                 315                 320 


Lys Gly Gln Ala Ser Ala Met Glu Leu Leu Arg Cys Pro Thr Leu Arg 
                325                 330                 335     


His Leu Phe Leu Cys Leu Ser Met Leu Trp Phe Ala Thr Ser Phe Ala 
            340                 345                 350         


Tyr Tyr Gly Leu Val Met Asp Leu Gln Gly Phe Gly Val Ser Ile Tyr 
        355                 360                 365             


Leu Ile Gln Val Ile Phe Gly Ala Val Asp Leu Pro Ala Lys Leu Val 
    370                 375                 380                 


Gly Phe Leu Val Ile Asn Ser Leu Gly Arg Arg Pro Ala Gln Met Ala 
385                 390                 395                 400 


Ala Leu Leu Leu Ala Gly Ile Cys Ile Leu Leu Asn Gly Val Ile Pro 
                405                 410                 415     


Gln Asp Gln Ser Ile Val Arg Thr Ser Leu Ala Val Leu Gly Lys Gly 
            420                 425                 430         


Cys Leu Ala Ala Ser Phe Asn Cys Ile Phe Leu Tyr Thr Gly Glu Leu 
        435                 440                 445             


Tyr Pro Thr Met Ile Arg Gln Thr Gly Met Gly Met Gly Ser Thr Met 
    450                 455                 460                 


Ala Arg Val Gly Ser Ile Val Ser Pro Leu Val Ser Met Thr Ala Glu 
465                 470                 475                 480 


Leu Tyr Pro Ser Met Pro Leu Phe Ile Tyr Gly Ala Val Pro Val Ala 
                485                 490                 495     


Ala Ser Ala Val Thr Val Leu Leu Pro Glu Thr Leu Gly Gln Pro Leu 
            500                 505                 510         


Pro Asp Thr Val Gln Asp Leu Glu Ser Arg Lys Gly Lys Gln Thr Arg 
        515                 520                 525             


Gln Gln Gln Glu His Gln Lys Tyr Met Val Pro Leu Gln Ala Ser Ala 
    530                 535                 540                 


Gln Glu Lys Asn Gly Leu 
545                 550 


<210>  6173
<211>  506
<212>  PRT
<213>  Homo sapiens

<400>  6173

Met Ala Phe Asn Asp Leu Leu Gln Gln Val Gly Gly Val Gly Arg Phe 
1               5                   10                  15      


Gln Gln Ile Gln Val Thr Leu Val Val Leu Pro Leu Leu Leu Met Ala 
            20                  25                  30          


Ser His Asn Thr Leu Gln Asn Phe Thr Ala Ala Ile Pro Thr His His 
        35                  40                  45              


Cys Arg Pro Pro Ala Asp Ala Asn Leu Ser Lys Asn Gly Gly Leu Glu 
    50                  55                  60                  


Val Trp Leu Pro Arg Asp Arg Gln Gly Gln Pro Glu Ser Cys Leu Arg 
65                  70                  75                  80  


Phe Thr Ser Pro Gln Trp Gly Leu Pro Phe Leu Asn Gly Thr Glu Ala 
                85                  90                  95      


Asn Gly Thr Gly Ala Thr Glu Pro Cys Thr Asp Gly Trp Ile Tyr Asp 
            100                 105                 110         


Asn Ser Thr Phe Pro Ser Thr Ile Val Thr Glu Trp Asp Leu Val Cys 
        115                 120                 125             


Ser His Arg Ala Leu Arg Gln Leu Ala Gln Ser Leu Tyr Met Val Gly 
    130                 135                 140                 


Val Leu Leu Gly Ala Met Val Phe Gly Tyr Leu Ala Asp Arg Leu Gly 
145                 150                 155                 160 


Arg Arg Lys Val Leu Ile Leu Asn Tyr Leu Gln Thr Ala Val Ser Gly 
                165                 170                 175     


Thr Cys Ala Ala Phe Ala Pro Asn Phe Pro Ile Tyr Cys Ala Phe Arg 
            180                 185                 190         


Leu Leu Ser Gly Met Ala Leu Ala Gly Ile Ser Leu Asn Cys Met Thr 
        195                 200                 205             


Leu Asn Val Glu Trp Met Pro Ile His Thr Arg Ala Cys Val Gly Thr 
    210                 215                 220                 


Leu Ile Gly Tyr Val Tyr Ser Leu Gly Gln Phe Leu Leu Ala Gly Val 
225                 230                 235                 240 


Ala Tyr Ala Val Pro His Trp Arg His Leu Gln Leu Leu Val Ser Ala 
                245                 250                 255     


Pro Phe Phe Ala Phe Phe Ile Tyr Ser Trp Phe Phe Ile Glu Ser Ala 
            260                 265                 270         


Arg Trp His Ser Ser Ser Gly Arg Leu Asp Leu Thr Leu Arg Ala Leu 
        275                 280                 285             


Gln Arg Val Ala Arg Ile Asn Gly Lys Arg Glu Glu Gly Ala Lys Leu 
    290                 295                 300                 


Ser Met Glu Val Leu Arg Ala Ser Leu Gln Lys Glu Leu Thr Met Gly 
305                 310                 315                 320 


Lys Gly Gln Ala Ser Ala Met Glu Leu Leu Arg Cys Pro Thr Leu Arg 
                325                 330                 335     


His Leu Phe Leu Cys Leu Ser Met Leu Trp Phe Ala Thr Ser Phe Ala 
            340                 345                 350         


Tyr Tyr Gly Leu Val Met Asp Leu Gln Gly Phe Gly Val Ser Ile Tyr 
        355                 360                 365             


Leu Ile Gln Val Ile Phe Gly Ala Val Asp Leu Pro Ala Lys Leu Val 
    370                 375                 380                 


Gly Phe Leu Val Ile Asn Ser Leu Gly Arg Arg Pro Ala Gln Met Ala 
385                 390                 395                 400 


Ala Leu Leu Leu Ala Gly Ile Cys Ile Leu Leu Asn Gly Val Ile Pro 
                405                 410                 415     


Gln Asp Gln Ser Ile Val Arg Thr Ser Leu Ala Val Leu Gly Lys Gly 
            420                 425                 430         


Cys Leu Ala Ala Ser Phe Asn Cys Ile Phe Leu Tyr Thr Gly Glu Leu 
        435                 440                 445             


Tyr Pro Thr Met Ile Arg Ala Val Thr Val Leu Leu Pro Glu Thr Leu 
    450                 455                 460                 


Gly Gln Pro Leu Pro Asp Thr Val Gln Asp Leu Glu Ser Arg Lys Gly 
465                 470                 475                 480 


Lys Gln Thr Arg Gln Gln Gln Glu His Gln Lys Tyr Met Val Pro Leu 
                485                 490                 495     


Gln Ala Ser Ala Gln Glu Lys Asn Gly Leu 
            500                 505     


<210>  6174
<211>  519
<212>  PRT
<213>  Homo sapiens

<400>  6174

Met Ala Phe Asn Asp Leu Leu Gln Gln Val Gly Gly Val Gly Arg Phe 
1               5                   10                  15      


Gln Gln Ile Gln Val Thr Leu Val Val Leu Pro Leu Leu Leu Met Ala 
            20                  25                  30          


Ser His Asn Thr Leu Gln Asn Phe Thr Ala Ala Ile Pro Thr His His 
        35                  40                  45              


Cys Arg Pro Pro Ala Asp Ala Asn Leu Ser Lys Asn Gly Gly Leu Glu 
    50                  55                  60                  


Val Trp Leu Pro Arg Asp Arg Gln Gly Gln Pro Glu Ser Cys Leu Arg 
65                  70                  75                  80  


Phe Thr Ser Pro Gln Trp Gly Leu Pro Phe Leu Asn Gly Thr Glu Ala 
                85                  90                  95      


Asn Gly Thr Gly Ala Thr Glu Pro Cys Thr Asp Gly Trp Ile Tyr Asp 
            100                 105                 110         


Asn Ser Thr Phe Pro Ser Thr Ile Val Thr Glu Trp Asp Leu Val Cys 
        115                 120                 125             


Ser His Arg Ala Leu Arg Gln Leu Ala Gln Ser Leu Tyr Met Val Gly 
    130                 135                 140                 


Val Leu Leu Gly Ala Met Val Phe Gly Tyr Leu Ala Asp Arg Leu Gly 
145                 150                 155                 160 


Arg Arg Lys Val Leu Ile Leu Asn Tyr Leu Gln Thr Ala Val Ser Gly 
                165                 170                 175     


Thr Cys Ala Ala Phe Ala Pro Asn Phe Pro Ile Tyr Cys Ala Phe Arg 
            180                 185                 190         


Leu Leu Ser Gly Met Ala Leu Ala Gly Ile Ser Leu Asn Cys Met Thr 
        195                 200                 205             


Leu Asn Val Glu Trp Met Pro Ile His Thr Arg Ala Cys Val Gly Thr 
    210                 215                 220                 


Leu Ile Gly Tyr Val Tyr Ser Leu Gly Gln Phe Leu Leu Ala Gly Val 
225                 230                 235                 240 


Ala Tyr Ala Val Pro His Trp Arg His Leu Gln Leu Leu Val Ser Ala 
                245                 250                 255     


Pro Phe Phe Ala Phe Phe Ile Tyr Ser Trp Phe Phe Ile Glu Ser Ala 
            260                 265                 270         


Arg Trp His Ser Ser Ser Gly Arg Leu Asp Leu Thr Leu Arg Ala Leu 
        275                 280                 285             


Gln Arg Val Ala Arg Ile Asn Gly Lys Arg Glu Glu Gly Ala Lys Leu 
    290                 295                 300                 


Ser Met Glu Val Leu Arg Ala Ser Leu Gln Lys Glu Leu Thr Met Gly 
305                 310                 315                 320 


Lys Gly Gln Ala Ser Ala Met Glu Leu Leu Arg Cys Pro Thr Leu Arg 
                325                 330                 335     


His Leu Phe Leu Cys Leu Ser Met Leu Trp Phe Ala Thr Ser Phe Ala 
            340                 345                 350         


Tyr Tyr Gly Leu Val Met Asp Leu Gln Gly Phe Gly Val Ser Ile Tyr 
        355                 360                 365             


Leu Ile Gln Val Ile Phe Gly Ala Val Asp Leu Pro Ala Lys Leu Val 
    370                 375                 380                 


Gly Phe Leu Val Ile Asn Ser Leu Gly Arg Arg Pro Ala Gln Met Ala 
385                 390                 395                 400 


Ala Leu Leu Leu Ala Gly Ile Cys Ile Leu Leu Asn Gly Val Ile Pro 
                405                 410                 415     


Gln Asp Gln Ser Ile Val Arg Thr Ser Leu Ala Val Leu Gly Lys Gly 
            420                 425                 430         


Cys Leu Ala Ala Ser Phe Asn Cys Ile Phe Leu Tyr Thr Gly Glu Leu 
        435                 440                 445             


Tyr Pro Thr Met Ile Arg Ala Val Thr Val Leu Leu Pro Glu Thr Leu 
    450                 455                 460                 


Gly Gln Pro Leu Pro Asp Thr Val Gln Asp Leu Glu Ser Arg Trp Ala 
465                 470                 475                 480 


Pro Thr Gln Lys Glu Ala Gly Ile Tyr Pro Arg Lys Gly Lys Gln Thr 
                485                 490                 495     


Arg Gln Gln Gln Glu His Gln Lys Tyr Met Val Pro Leu Gln Ala Ser 
            500                 505                 510         


Ala Gln Glu Lys Asn Gly Leu 
        515                 


<210>  6175
<211>  548
<212>  PRT
<213>  Homo sapiens

<400>  6175

Met Gly Phe Glu Glu Leu Leu Glu Gln Val Gly Gly Phe Gly Pro Phe 
1               5                   10                  15      


Gln Leu Arg Asn Val Ala Leu Leu Ala Leu Pro Arg Val Leu Leu Pro 
            20                  25                  30          


Leu His Phe Leu Leu Pro Ile Phe Leu Ala Ala Val Pro Ala His Arg 
        35                  40                  45              


Cys Ala Leu Pro Gly Ala Pro Ala Asn Phe Ser His Gln Asp Val Trp 
    50                  55                  60                  


Leu Glu Ala His Leu Pro Arg Glu Pro Asp Gly Thr Leu Ser Ser Cys 
65                  70                  75                  80  


Leu Arg Phe Ala Tyr Pro Gln Ala Leu Pro Asn Thr Thr Leu Gly Glu 
                85                  90                  95      


Glu Arg Gln Ser Arg Gly Glu Leu Glu Asp Glu Pro Ala Thr Val Pro 
            100                 105                 110         


Cys Ser Gln Gly Trp Glu Tyr Asp His Ser Glu Phe Ser Ser Thr Ile 
        115                 120                 125             


Ala Thr Glu Ser Gln Trp Asp Leu Val Cys Glu Gln Lys Gly Leu Asn 
    130                 135                 140                 


Arg Ala Ala Ser Thr Phe Phe Phe Ala Gly Val Leu Val Gly Ala Val 
145                 150                 155                 160 


Ala Phe Gly Tyr Leu Ser Asp Arg Phe Gly Arg Arg Arg Leu Leu Leu 
                165                 170                 175     


Val Ala Tyr Val Ser Thr Leu Val Leu Gly Leu Ala Ser Ala Ala Ser 
            180                 185                 190         


Val Ser Tyr Val Met Phe Ala Ile Thr Arg Thr Leu Thr Gly Ser Ala 
        195                 200                 205             


Leu Ala Gly Phe Thr Ile Ile Val Met Pro Leu Glu Leu Glu Trp Leu 
    210                 215                 220                 


Asp Val Glu His Arg Thr Val Ala Gly Val Leu Ser Ser Thr Phe Trp 
225                 230                 235                 240 


Thr Gly Gly Val Met Leu Leu Ala Leu Val Gly Tyr Leu Ile Arg Asp 
                245                 250                 255     


Trp Arg Trp Leu Leu Leu Ala Val Thr Leu Pro Cys Ala Pro Gly Ile 
            260                 265                 270         


Leu Ser Leu Trp Trp Val Pro Glu Ser Ala Arg Trp Leu Leu Thr Gln 
        275                 280                 285             


Gly His Val Lys Glu Ala His Arg Tyr Leu Leu His Cys Ala Arg Leu 
    290                 295                 300                 


Asn Gly Arg Pro Val Cys Glu Asp Ser Phe Ser Gln Glu Ala Val Ser 
305                 310                 315                 320 


Lys Val Ala Ala Gly Glu Arg Val Val Arg Arg Pro Ser Tyr Leu Asp 
                325                 330                 335     


Leu Phe Arg Thr Pro Arg Leu Arg His Ile Ser Leu Cys Cys Val Val 
            340                 345                 350         


Val Trp Phe Gly Val Asn Phe Ser Tyr Tyr Gly Leu Ser Leu Asp Val 
        355                 360                 365             


Ser Gly Leu Gly Leu Asn Val Tyr Gln Thr Gln Leu Leu Phe Gly Ala 
    370                 375                 380                 


Val Glu Leu Pro Ser Lys Leu Leu Val Tyr Leu Ser Val Arg Tyr Ala 
385                 390                 395                 400 


Gly Arg Arg Leu Thr Gln Ala Gly Thr Leu Leu Gly Thr Ala Leu Ala 
                405                 410                 415     


Phe Gly Thr Arg Leu Leu Val Ser Ser Asp Met Lys Ser Trp Ser Thr 
            420                 425                 430         


Val Leu Ala Val Met Gly Lys Ala Phe Ser Glu Ala Ala Phe Thr Thr 
        435                 440                 445             


Ala Tyr Leu Phe Thr Ser Glu Leu Tyr Pro Thr Val Leu Arg Gln Thr 
    450                 455                 460                 


Gly Met Gly Leu Thr Ala Leu Val Gly Arg Leu Gly Gly Ser Leu Ala 
465                 470                 475                 480 


Pro Leu Ala Ala Leu Leu Asp Gly Val Trp Leu Ser Leu Pro Lys Leu 
                485                 490                 495     


Thr Tyr Gly Gly Ile Ala Leu Leu Ala Ala Gly Thr Ala Leu Leu Leu 
            500                 505                 510         


Pro Glu Thr Arg Gln Ala Gln Leu Pro Glu Thr Ile Gln Asp Val Glu 
        515                 520                 525             


Arg Lys Ser Ala Pro Thr Ser Leu Gln Glu Glu Glu Met Pro Met Lys 
    530                 535                 540                 


Gln Val Gln Asn 
545             


<210>  6176
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  6176

Met Leu Leu Leu Leu Leu Ser Ile Ile Val Leu His Val Ala Val Leu 
1               5                   10                  15      


Val Leu Leu Phe Val Ser Thr Ile Val Ser Gln Trp Ile Val Gly Asn 
            20                  25                  30          


Gly His Ala Thr Asp Leu Trp Gln Asn Cys Ser Thr Ser Ser Ser Gly 
        35                  40                  45              


Asn Val His His Cys Phe Ser Ser Ser Pro Asn Glu Trp Leu Gln Ser 
    50                  55                  60                  


Val Gln Ala Thr Met Ile Leu Ser Ile Ile Phe Ser Ile Leu Ser Leu 
65                  70                  75                  80  


Phe Leu Phe Phe Cys Gln Leu Phe Thr Leu Thr Lys Gly Gly Arg Phe 
                85                  90                  95      


Tyr Ile Thr Gly Ile Phe Gln Ile Leu Ala Gly Leu Cys Val Met Ser 
            100                 105                 110         


Ala Ala Ala Ile Tyr Thr Val Arg His Pro Glu Trp His Leu Asn Ser 
        115                 120                 125             


Asp Tyr Ser Tyr Gly Phe Ala Tyr Ile Leu Ala Trp Val Ala Phe Pro 
    130                 135                 140                 


Leu Ala Leu Leu Ser Gly Val Ile Tyr Val Ile Leu Arg Lys Arg Glu 
145                 150                 155                 160 


<210>  6177
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  6177

Met Leu Leu Leu Leu Leu Ser Ile Ile Val Leu His Val Ala Val Leu 
1               5                   10                  15      


Val Leu Leu Phe Val Ser Thr Ile Val Ser Gln Trp Ile Val Gly Asn 
            20                  25                  30          


Gly His Ala Thr Asp Leu Trp Gln Asn Cys Ser Thr Ser Ser Ser Gly 
        35                  40                  45              


Asn Val His His Cys Phe Ser Ser Ser Pro Asn Glu Trp Leu Gln Ser 
    50                  55                  60                  


Val Gln Ala Thr Met Ile Leu Ser Ile Ile Phe Ser Ile Leu Ser Leu 
65                  70                  75                  80  


Phe Leu Phe Phe Cys Gln Leu Phe Thr Leu Thr Lys Gly Gly Arg Phe 
                85                  90                  95      


Tyr Ile Thr Gly Ile Phe Gln Ile Leu Ala Gly Leu Cys Val Met Ser 
            100                 105                 110         


Ala Ala Ala Ile Tyr Thr Val Arg His Pro Glu Trp His Leu Asn Ser 
        115                 120                 125             


Asp Tyr Ser Tyr Gly Phe Ala Tyr Ile Leu Ala Trp Val Ala Phe Pro 
    130                 135                 140                 


Leu Ala Leu Leu Ser Gly Val Ile Tyr Val Ile Leu Arg Lys Arg Glu 
145                 150                 155                 160 


<210>  6178
<211>  732
<212>  PRT
<213>  Homo sapiens

<400>  6178

Met Gly Ser Glu Lys Asp Ser Glu Ser Pro Arg Ser Thr Ser Leu His 
1               5                   10                  15      


Ala Ala Ala Pro Asp Pro Lys Cys Arg Ser Gly Gly Arg Arg Arg Arg 
            20                  25                  30          


Leu Thr Leu His Ser Val Phe Ser Ala Ser Ala Arg Gly Arg Arg Ala 
        35                  40                  45              


Arg Ala Lys Pro Gln Ala Glu Pro Pro Pro Pro Ala Ala Gln Pro Pro 
    50                  55                  60                  


Pro Ala Pro Ala Pro Ala Ala Ala Gln Gly Pro Pro Pro Glu Ala Leu 
65                  70                  75                  80  


Pro Ala Glu Pro Ala Ala Glu Ala Glu Ala Glu Ala Ala Ala Ala Ala 
                85                  90                  95      


Ala Glu Pro Gly Phe Asp Asp Glu Glu Ala Ala Glu Gly Gly Gly Pro 
            100                 105                 110         


Gly Ala Glu Glu Val Glu Cys Pro Leu Cys Leu Val Arg Leu Pro Pro 
        115                 120                 125             


Glu Arg Ala Pro Arg Leu Leu Ser Cys Pro His Arg Ser Cys Arg Asp 
    130                 135                 140                 


Cys Leu Arg His Tyr Leu Arg Leu Glu Ile Ser Glu Ser Arg Val Pro 
145                 150                 155                 160 


Ile Ser Cys Pro Glu Cys Ser Glu Arg Leu Asn Pro His Asp Ile Arg 
                165                 170                 175     


Leu Leu Leu Ala Asp Pro Pro Leu Met His Lys Tyr Glu Glu Phe Met 
            180                 185                 190         


Leu Arg Arg Tyr Leu Ala Ser Asp Pro Asp Cys Arg Trp Cys Pro Ala 
        195                 200                 205             


Pro Asp Cys Gly Tyr Ala Val Ile Ala Tyr Gly Cys Ala Ser Cys Pro 
    210                 215                 220                 


Lys Leu Thr Cys Glu Arg Glu Gly Cys Gln Thr Glu Phe Cys Tyr His 
225                 230                 235                 240 


Cys Lys Gln Ile Trp His Pro Asn Gln Thr Cys Asp Met Ala Arg Gln 
                245                 250                 255     


Gln Arg Ala Gln Thr Leu Arg Val Arg Thr Lys His Thr Ser Gly Leu 
            260                 265                 270         


Ser Tyr Gly Gln Glu Ser Gly Pro Ala Asp Asp Ile Lys Pro Cys Pro 
        275                 280                 285             


Arg Cys Ser Ala Tyr Ile Ile Lys Met Asn Asp Gly Ser Cys Asn His 
    290                 295                 300                 


Met Thr Cys Ala Val Cys Gly Cys Glu Phe Cys Trp Leu Cys Met Lys 
305                 310                 315                 320 


Glu Ile Ser Asp Leu His Tyr Leu Ser Pro Ser Gly Cys Thr Phe Trp 
                325                 330                 335     


Gly Lys Lys Pro Trp Ser Arg Lys Lys Lys Ile Leu Trp Gln Leu Gly 
            340                 345                 350         


Thr Leu Ile Gly Ala Pro Val Gly Ile Ser Leu Ile Ala Gly Ile Ala 
        355                 360                 365             


Ile Pro Ala Met Val Ile Gly Ile Pro Val Tyr Val Gly Arg Lys Ile 
    370                 375                 380                 


His Ser Arg Tyr Glu Gly Arg Lys Thr Ser Lys His Lys Arg Asn Leu 
385                 390                 395                 400 


Ala Ile Thr Gly Gly Val Thr Leu Ser Val Ile Ala Ser Pro Val Ile 
                405                 410                 415     


Ala Ala Val Ser Val Gly Ile Gly Val Pro Ile Met Leu Ala Tyr Val 
            420                 425                 430         


Tyr Gly Val Val Pro Ile Ser Leu Cys Arg Gly Gly Gly Cys Gly Val 
        435                 440                 445             


Ser Thr Ala Asn Gly Lys Gly Val Lys Ile Glu Phe Asp Glu Asp Asp 
    450                 455                 460                 


Gly Pro Ile Thr Val Ala Asp Ala Trp Arg Ala Leu Lys Asn Pro Ser 
465                 470                 475                 480 


Ile Gly Glu Ser Ser Ile Glu Gly Leu Thr Ser Val Leu Ser Thr Ser 
                485                 490                 495     


Gly Ser Pro Thr Asp Gly Leu Ser Val Met Gln Gly Pro Tyr Ser Glu 
            500                 505                 510         


Thr Ala Ser Phe Ala Ala Leu Ser Gly Gly Thr Leu Ser Gly Gly Ile 
        515                 520                 525             


Leu Ser Ser Gly Lys Gly Lys Tyr Ser Arg Leu Glu Val Gln Ala Asp 
    530                 535                 540                 


Val Gln Lys Glu Ile Phe Pro Lys Asp Thr Ala Ser Leu Gly Ala Ile 
545                 550                 555                 560 


Ser Asp Asn Ala Ser Thr Arg Ala Met Ala Gly Ser Ile Ile Ser Ser 
                565                 570                 575     


Tyr Asn Pro Gln Asp Arg Glu Cys Asn Asn Met Glu Ile Gln Val Asp 
            580                 585                 590         


Ile Glu Ala Lys Pro Ser His Tyr Gln Leu Val Ser Gly Ser Ser Thr 
        595                 600                 605             


Glu Asp Ser Leu His Val His Ala Gln Met Ala Glu Asn Glu Glu Glu 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Glu Glu Asp Pro Pro Cys Arg His Gln 
625                 630                 635                 640 


Ser Cys Glu Gln Lys Asp Cys Leu Ala Ser Lys Pro Trp Asp Ile Ser 
                645                 650                 655     


Leu Ala Gln Pro Glu Ser Ile Arg Ser Asp Leu Glu Ser Ser Asp Ala 
            660                 665                 670         


Gln Ser Asp Asp Val Pro Asp Ile Thr Ser Asp Glu Cys Gly Ser Pro 
        675                 680                 685             


Arg Ser His Thr Ala Ala Cys Pro Ser Thr Pro Arg Ala Gln Gly Ala 
    690                 695                 700                 


Pro Ser Pro Ser Ala His Met Asn Leu Ser Ala Leu Ala Glu Gly Gln 
705                 710                 715                 720 


Thr Val Leu Lys Pro Glu Gly Gly Glu Ala Arg Val 
                725                 730         


<210>  6179
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  6179

Met Thr Ala Trp Ile Leu Leu Pro Val Ser Leu Ser Ala Phe Ser Ile 
1               5                   10                  15      


Thr Gly Ile Trp Thr Val Tyr Ala Met Ala Val Met Asn His His Val 
            20                  25                  30          


Cys Pro Val Glu Asn Trp Ser Tyr Asn Glu Ser Cys Pro Pro Asp Pro 
        35                  40                  45              


Ala Glu Gln Gly Gly Pro Lys Thr Cys Cys Thr Leu Asp Asp Val Pro 
    50                  55                  60                  


Leu Ile Ser Lys Cys Gly Ser Tyr Pro Pro Glu Ser Cys Leu Phe Ser 
65                  70                  75                  80  


Leu Ile Gly Asn Met Gly Ala Phe Met Val Ala Leu Ile Cys Leu Leu 
                85                  90                  95      


Arg Tyr Gly Gln Leu Leu Glu Gln Ser Arg His Ser Trp Val Asn Thr 
            100                 105                 110         


Thr Ala Leu Ile Thr Gly Cys Thr Asn Ala Ala Gly Leu Leu Val Val 
        115                 120                 125             


Gly Asn Phe Gln Val Asp His Ala Arg Ser Leu His Tyr Val Gly Ala 
    130                 135                 140                 


Gly Val Ala Phe Pro Ala Gly Leu Leu Phe Val Cys Leu His Cys Ala 
145                 150                 155                 160 


Leu Ser Tyr Gln Gly Ala Thr Ala Pro Leu Asp Leu Ala Val Ala Tyr 
                165                 170                 175     


Leu Arg Ser Val Leu Ala Val Ile Ala Phe Ile Thr Leu Val Leu Ser 
            180                 185                 190         


Gly Val Phe Phe Val His Glu Ser Ser Gln Leu Gln His Gly Ala Ala 
        195                 200                 205             


Leu Cys Glu Trp Val Cys Val Ile Asp Ile Leu Ile Phe Tyr Gly Thr 
    210                 215                 220                 


Phe Ser Tyr Glu Phe Gly Ala Val Ser Ser Asp Thr Leu Val Ala Ala 
225                 230                 235                 240 


Leu Gln Pro Thr Pro Gly Arg Ala Cys Lys Ser Ser Gly Ser Ser Ser 
                245                 250                 255     


Thr Ser Thr His Leu Asn Cys Ala Pro Glu Ser Ile Ala Met Ile 
            260                 265                 270     


<210>  6180
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  6180

Met Val Pro Met His Leu Leu Gly Arg Leu Glu Lys Pro Leu Leu Leu 
1               5                   10                  15      


Leu Cys Cys Ala Ser Phe Leu Leu Gly Leu Ala Leu Leu Gly Ile Lys 
            20                  25                  30          


Thr Asp Ile Thr Pro Val Ala Tyr Phe Phe Leu Thr Leu Gly Gly Phe 
        35                  40                  45              


Phe Leu Phe Ala Tyr Leu Leu Val Arg Phe Leu Glu Trp Gly Leu Arg 
    50                  55                  60                  


Ser Gln Leu Gln Ser Met Gln Thr Glu Ser Pro Gly Pro Ser Gly Asn 
65                  70                  75                  80  


Ala Arg Asp Asn Glu Ala Phe Glu Val Pro Val Tyr Glu Glu Ala Val 
                85                  90                  95      


Val Gly Leu Glu Ser Gln Cys Arg Pro Gln Glu Leu Asp Gln Pro Pro 
            100                 105                 110         


Pro Tyr Ser Thr Val Val Ile Pro Pro Ala Pro Glu Glu Glu Gln Pro 
        115                 120                 125             


Ser His Pro Glu Gly Ser Arg Arg Ala Lys Leu Glu Gln Arg Arg Met 
    130                 135                 140                 


Ala Ser Glu Gly Ser Met Ala Gln Glu Gly Ser Pro Gly Arg Ala Pro 
145                 150                 155                 160 


Ile Asn Leu Arg Leu Arg Gly Pro Arg Ala Val Ser Thr Ala Pro Asp 
                165                 170                 175     


Leu Gln Ser Leu Ala Ala Val Pro Thr Leu Glu Pro Leu Thr Pro Pro 
            180                 185                 190         


Pro Ala Tyr Asp Val Cys Phe Gly His Pro Asp Asp Asp Ser Val Phe 
        195                 200                 205             


Tyr Glu Asp Asn Trp Ala Pro Pro 
    210                 215     


<210>  6181
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  6181

Met Val Ser Pro Val Thr Val Val Lys Ser Glu Gly Pro Lys Leu Val 
1               5                   10                  15      


Pro Phe Phe Lys Ala Thr Cys Val Tyr Phe Val Leu Trp Leu Pro Ser 
            20                  25                  30          


Ser Ser Pro Ser Trp Val Ser Thr Leu Ile Lys Cys Leu Pro Ile Phe 
        35                  40                  45              


Cys Leu Trp Leu Phe Leu Leu Ala His Gly Leu Gly Phe Leu Leu Ala 
    50                  55                  60                  


His Pro Ser Ala Thr Arg Ile Phe Val Gly Leu Val Phe Ser Ala Val 
65                  70                  75                  80  


Gly Asp Ala Phe Leu Ile Trp Gln Asp Gln Gly Tyr Phe Val His Gly 
                85                  90                  95      


Leu Leu Met Phe Ala Val Thr His Met Phe Tyr Ala Ser Ala Phe Gly 
            100                 105                 110         


Met Gln Pro Leu Ala Leu Arg Thr Gly Leu Val Met Ala Ala Leu Ser 
        115                 120                 125             


Gly Leu Cys Tyr Ala Leu Leu Tyr Pro Cys Leu Ser Gly Ala Phe Thr 
    130                 135                 140                 


Tyr Leu Val Gly Val Tyr Val Ala Leu Ile Gly Phe Met Gly Trp Arg 
145                 150                 155                 160 


Ala Met Ala Gly Leu Arg Leu Ala Gly Ala Asp Trp Arg Trp Thr Glu 
                165                 170                 175     


Leu Ala Ala Gly Ser Gly Ala Leu Phe Phe Ile Ile Ser Asp Leu Thr 
            180                 185                 190         


Ile Ala Leu Asn Lys Phe Cys Phe Pro Val Pro Tyr Ser Arg Ala Leu 
        195                 200                 205             


Ile Met Ser Thr Tyr Tyr Val Ala Gln Met Leu Val Ala Leu Ser Ala 
    210                 215                 220                 


Val Glu Ser Arg Glu Pro Val Glu His Tyr Arg Leu Thr Lys Ala Asn 
225                 230                 235                 240 


<210>  6182
<211>  487
<212>  PRT
<213>  Homo sapiens

<400>  6182

Met Gly Val Ile Gly Ile Gln Leu Val Val Thr Met Val Met Ala Ser 
1               5                   10                  15      


Val Met Gln Lys Ile Ile Pro His Tyr Ser Leu Ala Arg Trp Leu Leu 
            20                  25                  30          


Cys Asn Gly Ser Leu Arg Trp Tyr Gln His Pro Thr Glu Glu Glu Leu 
        35                  40                  45              


Arg Ile Leu Ala Gly Lys Gln Gln Lys Gly Lys Thr Lys Lys Asp Arg 
    50                  55                  60                  


Lys Tyr Asn Gly His Ile Glu Ser Lys Pro Leu Thr Ile Pro Lys Asp 
65                  70                  75                  80  


Ile Asp Leu His Leu Glu Thr Lys Ser Val Thr Glu Val Asp Thr Leu 
                85                  90                  95      


Ala Leu His Tyr Phe Pro Glu Tyr Gln Trp Leu Val Asp Phe Thr Val 
            100                 105                 110         


Ala Ala Thr Val Val Tyr Leu Val Thr Glu Val Tyr Tyr Asn Phe Met 
        115                 120                 125             


Lys Pro Thr Gln Glu Met Asn Ile Ser Leu Val Trp Cys Leu Leu Val 
    130                 135                 140                 


Leu Ser Phe Ala Ile Lys Val Leu Phe Ser Leu Thr Thr His Tyr Phe 
145                 150                 155                 160 


Lys Val Glu Asp Gly Gly Glu Arg Ser Val Cys Val Thr Phe Gly Phe 
                165                 170                 175     


Phe Phe Phe Val Lys Ala Met Ala Val Leu Ile Val Thr Glu Asn Tyr 
            180                 185                 190         


Leu Glu Phe Gly Leu Glu Thr Gly Phe Thr Asn Phe Ser Asp Ser Ala 
        195                 200                 205             


Met Gln Phe Leu Glu Lys Gln Gly Leu Glu Ser Gln Ser Pro Val Ser 
    210                 215                 220                 


Lys Leu Thr Phe Lys Phe Phe Leu Ala Ile Phe Cys Ser Phe Ile Gly 
225                 230                 235                 240 


Ala Phe Leu Thr Phe Pro Gly Leu Arg Leu Ala Gln Met His Leu Asp 
                245                 250                 255     


Ala Leu Asn Leu Ala Thr Glu Lys Ile Thr Gln Thr Leu Leu His Ile 
            260                 265                 270         


Asn Phe Leu Ala Pro Leu Phe Met Val Leu Leu Trp Val Lys Pro Ile 
        275                 280                 285             


Thr Lys Asp Tyr Ile Met Asn Pro Pro Leu Gly Lys Glu Ser Ile Pro 
    290                 295                 300                 


Leu Met Thr Glu Ala Thr Phe Asp Thr Leu Arg Leu Trp Leu Ile Ile 
305                 310                 315                 320 


Leu Leu Cys Ala Leu Arg Leu Ala Met Met Arg Ser His Leu Gln Ala 
                325                 330                 335     


Tyr Leu Asn Leu Ala Gln Lys Cys Val Asp Gln Met Lys Lys Glu Ala 
            340                 345                 350         


Gly Arg Ile Ser Thr Val Glu Leu Gln Lys Met Val Ala Arg Val Phe 
        355                 360                 365             


Tyr Tyr Leu Cys Val Ile Ala Leu Gln Tyr Val Ala Pro Leu Val Met 
    370                 375                 380                 


Leu Leu His Thr Thr Leu Leu Leu Lys Thr Leu Gly Asn His Ser Trp 
385                 390                 395                 400 


Gly Ile Tyr Pro Glu Ser Ile Ser Thr Leu Pro Val Asp Asn Ser Leu 
                405                 410                 415     


Leu Ser Asn Ser Val Tyr Ser Glu Leu Pro Ser Ala Glu Gly Lys Met 
            420                 425                 430         


Lys Val Thr Val Thr Gln Ile Thr Val Ala Leu Ser Ser Leu Lys Asn 
        435                 440                 445             


Ile Phe Thr Pro Leu Leu Phe Arg Gly Leu Leu Ser Phe Leu Thr Trp 
    450                 455                 460                 


Trp Ile Ala Ala Cys Leu Phe Ser Thr Ser Leu Phe Gly Leu Phe Tyr 
465                 470                 475                 480 


His Gln Tyr Leu Thr Val Ala 
                485         


<210>  6183
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  6183

Met Pro Ala Pro Gln Arg Lys His Arg Arg Gly Gly Phe Ser His Arg 
1               5                   10                  15      


Cys Phe Pro Thr Pro Gln Thr Ala Met Thr Pro Gln Pro Ala Gly Pro 
            20                  25                  30          


Pro Asp Gly Gly Trp Gly Trp Val Val Ala Ala Ala Ala Phe Ala Ile 
        35                  40                  45              


Asn Gly Leu Ser Tyr Gly Leu Leu Arg Ser Leu Gly Leu Ala Phe Pro 
    50                  55                  60                  


Asp Leu Ala Glu His Phe Asp Arg Ser Ala Gln Asp Thr Ala Trp Ile 
65                  70                  75                  80  


Ser Ala Leu Ala Leu Ala Val Gln Gln Ala Ala Ser Pro Val Gly Ser 
                85                  90                  95      


Ala Leu Ser Thr Arg Trp Gly Ala Arg Pro Val Val Met Val Gly Gly 
            100                 105                 110         


Val Leu Ala Ser Leu Gly Phe Val Phe Ser Ala Phe Ala Ser Asp Leu 
        115                 120                 125             


Leu His Leu Tyr Leu Gly Leu Gly Leu Leu Ala Gly Phe Gly Trp Ala 
    130                 135                 140                 


Leu Val Phe Ala Pro Ala Leu Gly Thr Leu Ser Arg Tyr Phe Ser Arg 
145                 150                 155                 160 


Arg Arg Val Leu Ala Val Gly Leu Ala Leu Thr Gly Asn Gly Ala Ser 
                165                 170                 175     


Ser Leu Leu Leu Ala Pro Ala Leu Gln Leu Leu Leu Asp Thr Phe Gly 
            180                 185                 190         


Trp Arg Gly Ala Leu Leu Leu Leu Gly Ala Ile Thr Leu His Leu Thr 
        195                 200                 205             


Pro Cys Gly Ala Leu Leu Leu Pro Leu Val Leu Pro Gly Asp Pro Pro 
    210                 215                 220                 


Ala Pro Pro Arg Ser Pro Leu Ala Ala Leu Gly Leu Ser Leu Phe Thr 
225                 230                 235                 240 


Arg Arg Ala Phe Ser Ile Phe Ala Leu Gly Thr Ala Leu Val Gly Gly 
                245                 250                 255     


Gly Tyr Phe Val Pro Tyr Val His Leu Ala Pro His Ala Leu Asp Arg 
            260                 265                 270         


Gly Leu Gly Gly Tyr Gly Ala Ala Leu Val Val Ala Val Ala Ala Met 
        275                 280                 285             


Gly Asp Ala Gly Ala Arg Leu Val Cys Gly Trp Leu Ala Asp Gln Gly 
    290                 295                 300                 


Trp Val Pro Leu Pro Arg Leu Leu Ala Val Phe Gly Ala Leu Thr Gly 
305                 310                 315                 320 


Leu Gly Leu Trp Val Val Gly Leu Val Pro Val Val Gly Gly Glu Glu 
                325                 330                 335     


Ser Trp Gly Gly Pro Leu Leu Ala Ala Ala Val Ala Tyr Gly Leu Ser 
            340                 345                 350         


Ala Gly Ser Tyr Ala Pro Leu Val Phe Gly Val Leu Pro Gly Leu Val 
        355                 360                 365             


Gly Val Gly Gly Val Val Gln Ala Thr Gly Leu Val Met Met Leu Met 
    370                 375                 380                 


Ser Leu Gly Gly Leu Leu Gly Pro Pro Leu Ser Gly Phe Leu Arg Asp 
385                 390                 395                 400 


Glu Thr Gly Asp Phe Thr Ala Ser Phe Leu Leu Ser Gly Ser Leu Ile 
                405                 410                 415     


Leu Ser Gly Ser Phe Ile Tyr Ile Gly Leu Pro Arg Ala Leu Pro Ser 
            420                 425                 430         


Cys Gly Pro Ala Ser Pro Pro Ala Thr Pro Pro Pro Glu Thr Gly Glu 
        435                 440                 445             


Leu Leu Pro Ala Pro Gln Ala Val Leu Leu Ser Pro Gly Gly Pro Gly 
    450                 455                 460                 


Ser Thr Leu Asp Thr Thr Cys 
465                 470     


<210>  6184
<211>  567
<212>  PRT
<213>  Homo sapiens

<400>  6184

Met Ala Gly Val Gly Asp Ala Ala Ala Pro Gly Glu Gly Gly Gly Gly 
1               5                   10                  15      


Gly Val Asp Gly Pro Gln Arg Asp Gly Arg Gly Glu Ala Glu Gln Pro 
            20                  25                  30          


Gly Gly Ser Gly Gly Gln Gly Pro Pro Pro Ala Pro Gln Leu Thr Glu 
        35                  40                  45              


Thr Leu Gly Phe Tyr Glu Ser Asp Arg Arg Arg Glu Arg Arg Arg Gly 
    50                  55                  60                  


Arg Thr Glu Leu Ser Leu Leu Arg Phe Leu Ser Ala Glu Leu Thr Arg 
65                  70                  75                  80  


Gly Tyr Phe Leu Glu His Asn Glu Ala Lys Tyr Thr Glu Arg Arg Glu 
                85                  90                  95      


Arg Val Tyr Thr Cys Leu Arg Ile Pro Arg Glu Leu Glu Lys Leu Met 
            100                 105                 110         


Val Phe Gly Ile Phe Leu Cys Leu Asp Ala Phe Leu Tyr Val Phe Thr 
        115                 120                 125             


Leu Leu Pro Leu Arg Val Phe Leu Ala Leu Phe Arg Leu Leu Thr Leu 
    130                 135                 140                 


Pro Cys Tyr Gly Leu Arg Asp Arg Arg Leu Leu Gln Pro Ala Gln Val 
145                 150                 155                 160 


Cys Asp Ile Leu Lys Gly Val Ile Leu Val Ile Cys Tyr Phe Met Met 
                165                 170                 175     


His Tyr Val Asp Tyr Ser Met Met Tyr His Leu Ile Arg Gly Gln Ser 
            180                 185                 190         


Val Ile Lys Leu Tyr Ile Ile Tyr Asn Met Leu Glu Val Ala Asp Arg 
        195                 200                 205             


Leu Phe Ser Ser Phe Gly Gln Asp Ile Leu Asp Ala Leu Tyr Trp Thr 
    210                 215                 220                 


Ala Thr Glu Pro Lys Glu Arg Lys Arg Ala His Ile Gly Val Ile Pro 
225                 230                 235                 240 


His Phe Phe Met Ala Val Leu Tyr Val Phe Leu His Ala Ile Leu Ile 
                245                 250                 255     


Met Val Gln Ala Thr Thr Leu Asn Val Ala Phe Asn Ser His Asn Lys 
            260                 265                 270         


Ser Leu Leu Thr Ile Met Met Ser Asn Asn Phe Val Glu Ile Lys Gly 
        275                 280                 285             


Ser Val Phe Lys Lys Phe Glu Lys Asn Asn Leu Phe Gln Met Ser Asn 
    290                 295                 300                 


Ser Asp Ile Lys Glu Arg Phe Thr Asn Tyr Val Leu Leu Leu Ile Val 
305                 310                 315                 320 


Cys Leu Arg Asn Met Glu Gln Phe Ser Trp Asn Pro Asp His Leu Trp 
                325                 330                 335     


Val Leu Phe Pro Asp Val Cys Met Val Ile Ala Ser Glu Ile Ala Val 
            340                 345                 350         


Asp Ile Val Lys His Ala Phe Ile Thr Lys Phe Asn Asp Ile Thr Ala 
        355                 360                 365             


Asp Val Tyr Ser Glu Tyr Arg Ala Ser Leu Ala Phe Asp Leu Val Ser 
    370                 375                 380                 


Ser Arg Gln Lys Asn Ala Tyr Thr Asp Tyr Ser Asp Ser Val Ala Arg 
385                 390                 395                 400 


Arg Met Gly Phe Ile Pro Leu Pro Leu Ala Val Leu Leu Ile Arg Val 
                405                 410                 415     


Val Thr Ser Ser Ile Lys Val Gln Gly Ile Leu Ser Tyr Ala Cys Val 
            420                 425                 430         


Ile Leu Phe Tyr Phe Gly Leu Ile Ser Leu Lys Val Leu Asn Ser Ile 
        435                 440                 445             


Val Leu Leu Gly Lys Ser Cys Gln Tyr Val Lys Glu Ala Lys Met Glu 
    450                 455                 460                 


Glu Lys Leu Ser Asn Pro Pro Ala Thr Cys Thr Pro Gly Lys Pro Ser 
465                 470                 475                 480 


Ser Lys Ser Gln Asn Lys Cys Lys Pro Ser Gln Gly Leu Ser Thr Glu 
                485                 490                 495     


Glu Asn Leu Ser Ala Ser Ile Thr Lys Gln Pro Ile His Gln Lys Glu 
            500                 505                 510         


Asn Ile Ile Pro Leu Leu Val Thr Ser Asn Ser Asp Gln Phe Leu Thr 
        515                 520                 525             


Thr Pro Asp Gly Asp Glu Lys Asp Ile Thr Gln Asp Asn Ser Glu Leu 
    530                 535                 540                 


Lys His Arg Ser Ser Lys Lys Asp Leu Leu Glu Ile Asp Arg Phe Thr 
545                 550                 555                 560 


Ile Cys Gly Asn Arg Ile Asp 
                565         


<210>  6185
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  6185

Met Glu Gly Val Asp Leu Leu Gly Phe Leu Ile Ile Thr Leu Asn Cys 
1               5                   10                  15      


Asn Val Thr Met Val Gly Lys Leu Trp Phe Val Leu Thr Met Leu Leu 
            20                  25                  30          


Arg Met Leu Val Ile Val Leu Ala Gly Arg Pro Val Tyr Gln Asp Glu 
        35                  40                  45              


Gln Glu Arg Phe Val Cys Asn Thr Leu Gln Pro Gly Cys Ala Asn Val 
    50                  55                  60                  


Cys Tyr Asp Val Phe Ser Pro Val Ser His Leu Arg Phe Trp Leu Ile 
65                  70                  75                  80  


Gln Gly Val Cys Val Leu Leu Pro Ser Ala Val Phe Ser Val Tyr Val 
                85                  90                  95      


Leu His Arg Gly Ala Thr Leu Ala Ala Leu Gly Pro Arg Arg Cys Pro 
            100                 105                 110         


Asp Pro Arg Glu Pro Ala Ser Gly Gln Arg Arg Cys Pro Arg Pro Phe 
        115                 120                 125             


Gly Glu Arg Gly Gly Leu Gln Val Pro Asp Phe Ser Ala Gly Tyr Ile 
    130                 135                 140                 


Ile His Leu Leu Leu Arg Thr Leu Leu Glu Ala Ala Phe Gly Ala Leu 
145                 150                 155                 160 


His Tyr Phe Leu Phe Gly Phe Leu Ala Pro Lys Lys Phe Pro Cys Thr 
                165                 170                 175     


Arg Pro Pro Cys Thr Gly Val Val Asp Cys Tyr Val Ser Arg Pro Thr 
            180                 185                 190         


Glu Lys Ser Leu Leu Met Leu Phe Leu Trp Ala Val Ser Ala Leu Ser 
        195                 200                 205             


Phe Leu Leu Gly Leu Ala Asp Leu Val Cys Ser Leu Arg Arg Arg Met 
    210                 215                 220                 


Arg Arg Arg Pro Gly Pro Pro Thr Ser Pro Ser Ile Arg Lys Gln Ser 
225                 230                 235                 240 


Gly Ala Ser Gly His Ala Glu Gly Arg Arg Thr Asp Glu Glu Gly Gly 
                245                 250                 255     


Arg Glu Glu Glu Gly Ala Pro Ala Pro Pro Gly Ala Arg Ala Gly Gly 
            260                 265                 270         


Glu Gly Ala Gly Ser Pro Arg Arg Thr Ser Arg Val Ser Gly His Thr 
        275                 280                 285             


Lys Ile Pro Asp Glu Asp Glu Ser Glu Val Thr Ser Ser Ala Ser Glu 
    290                 295                 300                 


Lys Leu Gly Arg Gln Pro Arg Gly Arg Pro His Arg Glu Ala Ala Gln 
305                 310                 315                 320 


Asp Pro Arg Gly Ser Gly Ser Glu Glu Gln Pro Ser Ala Ala Pro Ser 
                325                 330                 335     


Arg Leu Ala Ala Pro Pro Ser Cys Ser Ser Leu Gln Pro Pro Asp Pro 
            340                 345                 350         


Pro Ala Ser Ser Ser Gly Ala Pro His Leu Arg Ala Arg Lys Ser Glu 
        355                 360                 365             


Trp Val 
    370 


<210>  6186
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  6186

Met Leu Cys Ala Ser Phe Leu Gly Leu Gly Leu Ser Val Ala Ile Val 
1               5                   10                  15      


Gly Pro Thr Phe Gln Asp Leu Ala Thr Asn Val Asn Arg Asn Ile Ser 
            20                  25                  30          


Ser Leu Ser Phe Ile Phe Val Gly Arg Ala Leu Gly Tyr Leu Ser Gly 
        35                  40                  45              


Ser Val Ile Gly Gly Phe Leu Val Asp Val Met Asn Tyr Phe Leu Leu 
    50                  55                  60                  


Leu Gly Ile Ser Met Ser Ala Thr Thr Val Gly Leu Tyr Leu Val Pro 
65                  70                  75                  80  


Phe Cys Lys Thr Ala Ile Leu Leu Thr Val Met Met Ser Ile Phe Gly 
                85                  90                  95      


Val Ser Ile Gly Ile Leu Asp Thr Gly Gly Asn Val Leu Ile Leu Ala 
            100                 105                 110         


Ile Trp Gly Asp Lys Gly Ala Pro His Met Gln Ala Leu His Phe Ser 
        115                 120                 125             


Phe Ala Leu Gly Ala Phe Leu Ala Pro Leu Leu Ala Lys Leu Ala Leu 
    130                 135                 140                 


Gly Pro Thr Ala Ser Ala Glu Asn His Thr Glu Ser Asp Phe His Pro 
145                 150                 155                 160 


Ala Leu Asn Gln Ser Ser Asp Ala Asp Ser Glu Ala Leu Phe Gly Val 
                165                 170                 175     


Pro Asn Asp Lys Asn Leu Leu Trp Ala Tyr Ala Val Ile Gly Thr Tyr 
            180                 185                 190         


Met Phe Leu Val Ser Val Ile Phe Phe Cys Leu Phe Leu Lys Asn Ser 
        195                 200                 205             


Ser Lys Gln Glu Lys Ala Arg Ala Ser Ala Glu Thr Phe Arg Arg Ala 
    210                 215                 220                 


Lys Tyr His Asn Ala Leu Leu Cys Leu Leu Phe Leu Phe Phe Phe Phe 
225                 230                 235                 240 


Tyr Val Gly Ala Glu Val Thr Tyr Gly Ser Tyr Val Phe Ser Phe Ala 
                245                 250                 255     


Thr Thr His Ala Gly Met Lys Glu Ser Glu Ala Ala Gly Leu Asn Ser 
            260                 265                 270         


Ile Phe Trp Gly Thr Phe Ala Ala Cys Arg Gly Leu Ala Ile Phe Phe 
        275                 280                 285             


Ala Thr Cys Leu Gln Pro Gly Thr Met Ile Val Leu Ser Asn Ile Gly 
    290                 295                 300                 


Ser Leu Thr Ser Ser Leu Phe Leu Val Leu Phe Asp Lys Asn Pro Ile 
305                 310                 315                 320 


Cys Leu Trp Ile Ala Thr Ser Val Tyr Gly Ala Ser Met Ala Thr Thr 
                325                 330                 335     


Phe Pro Ser Gly Val Ser Trp Ile Glu Gln Tyr Thr Thr Ile His Gly 
            340                 345                 350         


Lys Ser Ala Ala Phe Phe Val Ile Gly Ala Ser Leu Gly Glu Met Ala 
        355                 360                 365             


Ile Pro Ala Val Ile Gly Ile Leu Gln Gly Lys Tyr Pro Asp Leu Pro 
    370                 375                 380                 


Val Val Leu Tyr Thr Ser Leu Gly Ala Ser Ile Ala Thr Gly Ile Leu 
385                 390                 395                 400 


Phe Pro Val Leu Tyr Lys Leu Ala Thr Ser Pro Leu Asp Arg Gln Arg 
                405                 410                 415     


Lys Glu Asp Arg Lys Ser Glu Asp Gln Lys Ala Leu Leu Ser Ser Ser 
            420                 425                 430         


Gly Leu Asn Glu Tyr Glu Glu Glu Asn Glu Glu Glu Asp Ala Glu Lys 
        435                 440                 445             


Trp Asn Glu Met Asp Phe Glu Met Ile Glu Thr Asn Asp Thr Met Arg 
    450                 455                 460                 


His Ser Ile Ile Glu Thr Ser Arg Ser Ser Leu Thr Glu Pro Thr Ala 
465                 470                 475                 480 


Glu Val Tyr Asn Gln Tyr Pro Ser Asn Ala Leu Val Phe Glu Ser Ser 
                485                 490                 495     


Pro Phe Asn Thr Gly Ser Ala His Val Lys His Leu Pro Glu Thr Arg 
            500                 505                 510         


Thr Lys Gly Thr Asn Val 
        515             


<210>  6187
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  6187

Met His Gly Ser Cys Ser Phe Leu Met Leu Leu Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Leu Val Ala Thr Thr Gly Pro Val Gly Ala Leu Thr Asp Glu Glu 
            20                  25                  30          


Lys Arg Leu Met Val Glu Leu His Asn Leu Tyr Arg Ala Gln Val Ser 
        35                  40                  45              


Pro Thr Ala Ser Asp Met Leu His Met Arg Trp Asp Glu Glu Leu Ala 
    50                  55                  60                  


Ala Phe Ala Lys Ala Tyr Ala Arg Gln Cys Val Trp Gly His Asn Lys 
65                  70                  75                  80  


Glu Arg Gly Arg Arg Gly Glu Asn Leu Phe Ala Ile Thr Asp Glu Gly 
                85                  90                  95      


Met Asp Val Pro Leu Ala Met Glu Glu Trp His His Glu Arg Glu His 
            100                 105                 110         


Tyr Asn Leu Ser Ala Ala Thr Cys Ser Pro Gly Gln Met Cys Gly His 
        115                 120                 125             


Tyr Thr Gln Val Val Trp Ala Lys Thr Glu Arg Ile Gly Cys Gly Ser 
    130                 135                 140                 


His Phe Cys Glu Lys Leu Gln Gly Val Glu Glu Thr Asn Ile Glu Leu 
145                 150                 155                 160 


Leu Val Cys Asn Tyr Glu Pro Pro Gly Asn Val Lys Gly Lys Arg Pro 
                165                 170                 175     


Tyr Gln Glu Gly Thr Pro Cys Ser Gln Cys Pro Ser Gly Tyr His Cys 
            180                 185                 190         


Lys Asn Ser Leu Cys Glu Pro Ile Gly Ser Pro Glu Asp Ala Gln Asp 
        195                 200                 205             


Leu Pro Tyr Leu Val Thr Glu Ala Pro Ser Phe Arg Ala Thr Glu Ala 
    210                 215                 220                 


Ser Asp Ser Arg Lys Met Gly Thr Pro Ser Ser Leu Ala Thr Gly Ile 
225                 230                 235                 240 


Pro Ala Phe Leu Val Thr Glu Val Ser Gly Ser Leu Ala Thr Lys Ala 
                245                 250                 255     


Leu Pro Ala Val Glu Thr Gln Ala Pro Thr Ser Leu Ala Thr Lys Asp 
            260                 265                 270         


Pro Pro Ser Met Ala Thr Glu Ala Pro Pro Cys Val Thr Thr Glu Val 
        275                 280                 285             


Pro Ser Ile Leu Ala Ala His Ser Leu Pro Ser Leu Asp Glu Glu Pro 
    290                 295                 300                 


Val Thr Phe Pro Lys Ser Thr His Val Pro Ile Pro Lys Ser Ala Asp 
305                 310                 315                 320 


Lys Val Thr Asp Lys Thr Lys Val Pro Ser Arg Ser Pro Glu Asn Ser 
                325                 330                 335     


Leu Asp Pro Lys Met Ser Leu Thr Gly Ala Arg Glu Leu Leu Pro His 
            340                 345                 350         


Ala Gln Glu Glu Ala Glu Ala Glu Ala Glu Leu Pro Pro Ser Ser Glu 
        355                 360                 365             


Val Leu Ala Ser Val Phe Pro Ala Gln Asp Lys Pro Gly Glu Leu Gln 
    370                 375                 380                 


Ala Thr Leu Asp His Thr Gly His Thr Ser Ser Lys Ser Leu Pro Asn 
385                 390                 395                 400 


Phe Pro Asn Thr Ser Ala Thr Ala Asn Ala Thr Gly Gly Arg Ala Leu 
                405                 410                 415     


Ala Leu Gln Ser Ser Leu Pro Gly Ala Glu Gly Pro Asp Lys Pro Ser 
            420                 425                 430         


Val Val Ser Gly Leu Asn Ser Gly Pro Gly His Val Trp Gly Pro Leu 
        435                 440                 445             


Leu Gly Leu Leu Leu Leu Pro Pro Leu Val Leu Ala Gly Ile Phe 
    450                 455                 460             


<210>  6188
<211>  1119
<212>  PRT
<213>  Homo sapiens

<400>  6188

Met Ser Ala Pro Ser Leu Arg Ala Arg Ala Ala Gly Leu Gly Leu Leu 
1               5                   10                  15      


Leu Cys Ala Val Leu Gly Arg Ala Gly Arg Ser Asp Ser Gly Gly Arg 
            20                  25                  30          


Gly Glu Leu Gly Gln Pro Ser Gly Val Ala Ala Glu Arg Pro Cys Pro 
        35                  40                  45              


Thr Thr Cys Arg Cys Leu Gly Asp Leu Leu Asp Cys Ser Arg Lys Arg 
    50                  55                  60                  


Leu Ala Arg Leu Pro Glu Pro Leu Pro Ser Trp Val Ala Arg Leu Asp 
65                  70                  75                  80  


Leu Ser His Asn Arg Leu Ser Phe Ile Lys Ala Ser Ser Met Ser His 
                85                  90                  95      


Leu Gln Ser Leu Arg Glu Val Lys Leu Asn Asn Asn Glu Leu Glu Thr 
            100                 105                 110         


Ile Pro Asn Leu Gly Pro Val Ser Ala Asn Ile Thr Leu Leu Ser Leu 
        115                 120                 125             


Ala Gly Asn Arg Ile Val Glu Ile Leu Pro Glu His Leu Lys Glu Phe 
    130                 135                 140                 


Gln Ser Leu Glu Thr Leu Asp Leu Ser Ser Asn Asn Ile Ser Glu Leu 
145                 150                 155                 160 


Gln Thr Ala Phe Pro Ala Leu Gln Leu Lys Tyr Leu Tyr Leu Asn Ser 
                165                 170                 175     


Asn Arg Val Thr Ser Met Glu Pro Gly Tyr Phe Asp Asn Leu Ala Asn 
            180                 185                 190         


Thr Leu Leu Val Leu Lys Leu Asn Arg Asn Arg Ile Ser Ala Ile Pro 
        195                 200                 205             


Pro Lys Met Phe Lys Leu Pro Gln Leu Gln His Leu Glu Leu Asn Arg 
    210                 215                 220                 


Asn Lys Ile Lys Asn Val Asp Gly Leu Thr Phe Gln Gly Leu Gly Ala 
225                 230                 235                 240 


Leu Lys Ser Leu Lys Met Gln Arg Asn Gly Val Thr Lys Leu Met Asp 
                245                 250                 255     


Gly Ala Phe Trp Gly Leu Ser Asn Met Glu Ile Leu Gln Leu Asp His 
            260                 265                 270         


Asn Asn Leu Thr Glu Ile Thr Lys Gly Trp Leu Tyr Gly Leu Leu Met 
        275                 280                 285             


Leu Gln Glu Leu His Leu Ser Gln Asn Ala Ile Asn Arg Ile Ser Pro 
    290                 295                 300                 


Asp Ala Trp Glu Phe Cys Gln Lys Leu Ser Glu Leu Asp Leu Thr Phe 
305                 310                 315                 320 


Asn His Leu Ser Arg Leu Asp Asp Ser Ser Phe Leu Gly Leu Ser Leu 
                325                 330                 335     


Leu Asn Thr Leu His Ile Gly Asn Asn Arg Val Ser Tyr Ile Ala Asp 
            340                 345                 350         


Cys Ala Phe Arg Gly Leu Ser Ser Leu Lys Thr Leu Asp Leu Lys Asn 
        355                 360                 365             


Asn Glu Ile Ser Trp Thr Ile Glu Asp Met Asn Gly Ala Phe Ser Gly 
    370                 375                 380                 


Leu Asp Lys Leu Arg Arg Leu Ile Leu Gln Gly Asn Arg Ile Arg Ser 
385                 390                 395                 400 


Ile Thr Lys Lys Ala Phe Thr Gly Leu Asp Ala Leu Glu His Leu Asp 
                405                 410                 415     


Leu Ser Asp Asn Ala Ile Met Ser Leu Gln Gly Asn Ala Phe Ser Gln 
            420                 425                 430         


Met Lys Lys Leu Gln Gln Leu His Leu Asn Thr Ser Ser Leu Leu Cys 
        435                 440                 445             


Asp Cys Gln Leu Lys Trp Leu Pro Gln Trp Val Ala Glu Asn Asn Phe 
    450                 455                 460                 


Gln Ser Phe Val Asn Ala Ser Cys Ala His Pro Gln Leu Leu Lys Gly 
465                 470                 475                 480 


Arg Ser Ile Phe Ala Val Ser Pro Asp Gly Phe Val Cys Asp Asp Phe 
                485                 490                 495     


Pro Lys Pro Gln Ile Thr Val Gln Pro Glu Thr Gln Ser Ala Ile Lys 
            500                 505                 510         


Gly Ser Asn Leu Ser Phe Ile Cys Ser Ala Ala Ser Ser Ser Asp Ser 
        515                 520                 525             


Pro Met Thr Phe Ala Trp Lys Lys Asp Asn Glu Leu Leu His Asp Ala 
    530                 535                 540                 


Glu Met Glu Asn Tyr Ala His Leu Arg Ala Gln Gly Gly Glu Val Met 
545                 550                 555                 560 


Glu Tyr Thr Thr Ile Leu Arg Leu Arg Glu Val Glu Phe Ala Ser Glu 
                565                 570                 575     


Gly Lys Tyr Gln Cys Val Ile Ser Asn His Phe Gly Ser Ser Tyr Ser 
            580                 585                 590         


Val Lys Ala Lys Leu Thr Val Asn Met Leu Pro Ser Phe Thr Lys Thr 
        595                 600                 605             


Pro Met Asp Leu Thr Ile Arg Ala Gly Ala Met Ala Arg Leu Glu Cys 
    610                 615                 620                 


Ala Ala Val Gly His Pro Ala Pro Gln Ile Ala Trp Gln Lys Asp Gly 
625                 630                 635                 640 


Gly Thr Asp Phe Pro Ala Ala Arg Glu Arg Arg Met His Val Met Pro 
                645                 650                 655     


Glu Asp Asp Val Phe Phe Ile Val Asp Val Lys Ile Glu Asp Ile Gly 
            660                 665                 670         


Val Tyr Ser Cys Thr Ala Gln Asn Ser Ala Gly Ser Ile Ser Ala Asn 
        675                 680                 685             


Ala Thr Leu Thr Val Leu Glu Thr Pro Ser Phe Leu Arg Pro Leu Leu 
    690                 695                 700                 


Asp Arg Thr Val Thr Lys Gly Glu Thr Ala Val Leu Gln Cys Ile Ala 
705                 710                 715                 720 


Gly Gly Ser Pro Pro Pro Lys Leu Asn Trp Thr Lys Asp Asp Ser Pro 
                725                 730                 735     


Leu Val Val Thr Glu Arg His Phe Phe Ala Ala Gly Asn Gln Leu Leu 
            740                 745                 750         


Ile Ile Val Asp Ser Asp Val Ser Asp Ala Gly Lys Tyr Thr Cys Glu 
        755                 760                 765             


Met Ser Asn Thr Leu Gly Thr Glu Arg Gly Asn Val Arg Leu Ser Val 
    770                 775                 780                 


Ile Pro Thr Pro Thr Cys Asp Ser Pro Gln Met Thr Ala Pro Ser Leu 
785                 790                 795                 800 


Asp Asp Asp Gly Trp Ala Thr Val Gly Val Val Ile Ile Ala Val Val 
                805                 810                 815     


Cys Cys Val Val Gly Thr Ser Leu Val Trp Val Val Ile Ile Tyr His 
            820                 825                 830         


Thr Arg Arg Arg Asn Glu Asp Cys Ser Ile Thr Asn Thr Asp Glu Thr 
        835                 840                 845             


Asn Leu Pro Ala Asp Ile Pro Ser Tyr Leu Ser Ser Gln Gly Thr Leu 
    850                 855                 860                 


Ala Asp Arg Gln Asp Gly Tyr Val Ser Ser Glu Ser Gly Ser His His 
865                 870                 875                 880 


Gln Phe Val Thr Ser Ser Gly Ala Gly Phe Phe Leu Pro Gln His Asp 
                885                 890                 895     


Ser Ser Gly Thr Cys His Ile Asp Asn Ser Ser Glu Ala Asp Val Glu 
            900                 905                 910         


Ala Ala Thr Asp Leu Phe Leu Cys Pro Phe Leu Gly Ser Thr Gly Pro 
        915                 920                 925             


Met Tyr Leu Lys Gly Asn Val Tyr Gly Ser Asp Pro Phe Glu Thr Tyr 
    930                 935                 940                 


His Thr Gly Cys Ser Pro Asp Pro Arg Thr Val Leu Met Asp His Tyr 
945                 950                 955                 960 


Glu Pro Ser Tyr Ile Lys Lys Lys Glu Cys Tyr Pro Cys Ser His Pro 
                965                 970                 975     


Ser Glu Glu Ser Cys Glu Arg Ser Phe Ser Asn Ile Ser Trp Pro Ser 
            980                 985                 990         


His Val Arg Lys Leu Leu Asn Thr  Ser Tyr Ser His Asn  Glu Gly Pro 
        995                 1000                 1005             


Gly Met  Lys Asn Leu Cys Leu  Asn Lys Ser Ser Leu  Asp Phe Ser 
    1010                 1015                 1020             


Ala Asn  Pro Glu Pro Ala Ser  Val Ala Ser Ser Asn  Ser Phe Met 
    1025                 1030                 1035             


Gly Thr  Phe Gly Lys Ala Leu  Arg Arg Pro His Leu  Asp Ala Tyr 
    1040                 1045                 1050             


Ser Ser  Phe Gly Gln Pro Ser  Asp Cys Gln Pro Arg  Ala Phe Tyr 
    1055                 1060                 1065             


Leu Lys  Ala His Ser Ser Pro  Asp Leu Asp Ser Gly  Ser Glu Glu 
    1070                 1075                 1080             


Asp Gly  Lys Glu Arg Thr Asp  Phe Gln Glu Glu Asn  His Ile Cys 
    1085                 1090                 1095             


Thr Phe  Lys Gln Thr Leu Glu  Asn Tyr Arg Thr Pro  Asn Phe Gln 
    1100                 1105                 1110             


Ser Tyr  Asp Leu Asp Thr 
    1115                 


<210>  6189
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  6189

Met Glu Trp Thr Ala Ala Arg Ala Arg Pro Leu Val Met Thr Leu Asn 
1               5                   10                  15      


Ser Leu Gly Phe Ser Phe Gly His Gly Leu Thr Ala Ala Val Ala Tyr 
            20                  25                  30          


Gly Val Arg Asp Trp Thr Leu Leu Gln Leu Val Val Ser Val Pro Phe 
        35                  40                  45              


Phe Leu Cys Phe Leu Tyr Ser Trp Trp Leu Ala Glu Ser Ala Arg Trp 
    50                  55                  60                  


Leu Leu Thr Thr Gly Arg Leu Asp Trp Gly Leu Gln Glu Leu Trp Arg 
65                  70                  75                  80  


Val Ala Ala Ile Asn Gly Lys Gly Ala Val Gln Asp Thr Leu Thr Pro 
                85                  90                  95      


Glu Val Leu Leu Ser Ala Met Arg Glu Glu Leu Ser Met Gly Gln Pro 
            100                 105                 110         


Pro Ala Ser Leu Gly Thr Leu Leu Arg Met Pro Gly Leu Arg Phe Arg 
        115                 120                 125             


Thr Cys Ile Ser Thr Leu Cys Trp Phe Ala Phe Gly Phe Thr Phe Phe 
    130                 135                 140                 


Gly Leu Ala Leu Asp Leu Gln Ala Leu Gly Ser Asn Ile Phe Leu Leu 
145                 150                 155                 160 


Gln Met Phe Ile Gly Val Val Asp Ile Pro Ala Lys Met Gly Ala Leu 
                165                 170                 175     


Leu Leu Leu Ser His Leu Gly Arg Arg Pro Thr Leu Ala Ala Ser Leu 
            180                 185                 190         


Leu Leu Ala Gly Leu Cys Ile Leu Ala Asn Thr Leu Val Pro His Glu 
        195                 200                 205             


Met Gly Ala Leu Arg Ser Ala Leu Ala Val Leu Gly Leu Gly Gly Val 
    210                 215                 220                 


Gly Ala Ala Phe Thr Cys Ile Thr Ile Tyr Ser Ser Glu Leu Phe Pro 
225                 230                 235                 240 


Thr Val Leu Arg Met Thr Ala Val Gly Leu Gly Gln Met Ala Ala Arg 
                245                 250                 255     


Gly Gly Ala Ile Leu Gly Pro Leu Val Arg Leu Leu Gly Val His Gly 
            260                 265                 270         


Pro Trp Leu Pro Leu Leu Val Tyr Gly Thr Val Pro Val Leu Ser Gly 
        275                 280                 285             


Leu Ala Ala Leu Leu Leu Pro Glu Thr Gln Ser Leu Pro Leu Pro Asp 
    290                 295                 300                 


Thr Ile Gln Asp Val Gln Asn Gln Ala Val Lys Lys Ala Thr His Gly 
305                 310                 315                 320 


Thr Leu Gly Asn Ser Val Leu Lys Ser Thr Gln Phe 
                325                 330         


<210>  6190
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  6190

Met Asn Ser Trp Asp Ala Gly Leu Ala Gly Leu Leu Val Gly Thr Met 
1               5                   10                  15      


Gly Val Ser Leu Leu Ser Asn Ala Leu Val Leu Leu Cys Leu Leu His 
            20                  25                  30          


Ser Ala Asp Ile Arg Arg Gln Ala Pro Ala Leu Phe Thr Leu Asn Leu 
        35                  40                  45              


Thr Cys Gly Asn Leu Leu Cys Thr Val Val Asn Met Pro Leu Thr Leu 
    50                  55                  60                  


Ala Gly Val Val Ala Gln Arg Gln Pro Ala Gly Asp Arg Leu Cys Arg 
65                  70                  75                  80  


Leu Ala Ala Phe Leu Asp Thr Phe Leu Ala Ala Asn Ser Met Leu Ser 
                85                  90                  95      


Met Ala Ala Leu Ser Ile Asp Arg Trp Val Ala Val Val Phe Pro Leu 
            100                 105                 110         


Ser Tyr Arg Ala Lys Met Arg Leu Arg Asp Ala Ala Leu Met Val Ala 
        115                 120                 125             


Tyr Thr Trp Leu His Ala Leu Thr Phe Pro Ala Ala Ala Leu Ala Leu 
    130                 135                 140                 


Ser Trp Leu Gly Phe His Gln Leu Tyr Ala Ser Cys Thr Leu Cys Ser 
145                 150                 155                 160 


Arg Arg Pro Asp Glu Arg Leu Arg Phe Ala Val Phe Thr Gly Ala Phe 
                165                 170                 175     


His Ala Leu Ser Phe Leu Leu Ser Phe Val Val Leu Cys Cys Thr Tyr 
            180                 185                 190         


Leu Lys Val Leu Lys Val Ala Arg Phe His Cys Lys Arg Ile Asp Val 
        195                 200                 205             


Ile Thr Met Gln Thr Leu Val Leu Leu Val Asp Leu His Pro Ser Val 
    210                 215                 220                 


Arg Glu Arg Cys Leu Glu Glu Gln Lys Arg Arg Arg Gln Arg Ala Thr 
225                 230                 235                 240 


Lys Lys Ile Ser Thr Phe Ile Gly Thr Phe Leu Val Cys Phe Ala Pro 
                245                 250                 255     


Tyr Val Ile Thr Arg Leu Val Glu Leu Phe Ser Thr Val Pro Ile Gly 
            260                 265                 270         


Ser His Trp Gly Val Leu Ser Lys Cys Leu Ala Tyr Ser Lys Ala Ala 
        275                 280                 285             


Ser Asp Pro Phe Val Tyr Ser Leu Leu Arg His Gln Tyr Arg Lys Ser 
    290                 295                 300                 


Cys Lys Glu Ile Leu Asn Arg Leu Leu His Arg Arg Ser Ile His Ser 
305                 310                 315                 320 


Ser Gly Leu Thr Gly Asp Ser His Ser Gln Asn Ile Leu Pro Val Ser 
                325                 330                 335     


Glu 
    


<210>  6191
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  6191

Met Asn Ser Leu Lys Asp Gly Asn His Thr Ala Leu Thr Gly Phe Ile 
1               5                   10                  15      


Leu Leu Gly Leu Thr Asp Asp Pro Ile Leu Arg Val Ile Leu Phe Met 
            20                  25                  30          


Ile Ile Leu Ser Gly Asn Leu Ser Ile Ile Ile Leu Ile Arg Ile Ser 
        35                  40                  45              


Ser Gln Leu His His Pro Met Tyr Phe Phe Leu Ser His Leu Ala Phe 
    50                  55                  60                  


Ala Asp Met Ala Tyr Ser Ser Ser Val Thr Pro Asn Met Leu Val Asn 
65                  70                  75                  80  


Phe Leu Val Glu Arg Asn Thr Val Ser Tyr Leu Gly Cys Ala Ile Gln 
                85                  90                  95      


Leu Gly Ser Ala Ala Phe Phe Ala Thr Val Glu Cys Val Leu Leu Ala 
            100                 105                 110         


Ala Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Ser Pro Leu Leu Tyr 
        115                 120                 125             


Ser Thr Lys Met Ser Thr Gln Val Ser Val Gln Leu Leu Leu Val Val 
    130                 135                 140                 


Tyr Ile Ala Gly Phe Leu Ile Ala Val Ser Tyr Thr Thr Ser Phe Tyr 
145                 150                 155                 160 


Phe Leu Leu Phe Cys Gly Pro Asn Gln Val Asn His Phe Phe Cys Asp 
                165                 170                 175     


Phe Ala Pro Leu Leu Glu Leu Ser Cys Ser Asp Ile Ser Val Ser Thr 
            180                 185                 190         


Val Val Leu Ser Phe Ser Ser Gly Ser Ile Ile Val Val Thr Val Cys 
        195                 200                 205             


Val Ile Ala Val Cys Tyr Ile Tyr Ile Leu Ile Thr Ile Leu Lys Met 
    210                 215                 220                 


Arg Ser Thr Glu Gly His His Lys Ala Phe Ser Thr Cys Thr Ser His 
225                 230                 235                 240 


Leu Thr Val Val Thr Leu Phe Tyr Gly Thr Ile Thr Phe Ile Tyr Val 
                245                 250                 255     


Met Pro Asn Phe Ser Tyr Ser Thr Asp Gln Asn Lys Val Val Ser Val 
            260                 265                 270         


Leu Tyr Thr Val Val Ile Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu 
        275                 280                 285             


Arg Asn Lys Glu Ile Lys Gly Ala Leu Lys Arg Glu Leu Val Arg Lys 
    290                 295                 300                 


Ile Leu Ser His Asp Ala Cys Tyr Phe Ser Arg Thr Ser Asn Asn Asp 
305                 310                 315                 320 


Ile Thr 
        


<210>  6192
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  6192

Met Gly Thr Gly Asn Asp Thr Thr Val Val Glu Phe Thr Leu Leu Gly 
1               5                   10                  15      


Leu Ser Glu Asp Thr Thr Val Cys Ala Ile Leu Phe Leu Val Phe Leu 
            20                  25                  30          


Gly Ile Tyr Val Val Thr Leu Met Gly Asn Ile Ser Ile Ile Val Leu 
        35                  40                  45              


Ile Arg Arg Ser His His Leu His Thr Pro Met Tyr Ile Phe Leu Cys 
    50                  55                  60                  


His Leu Ala Phe Val Asp Ile Gly Tyr Ser Ser Ser Val Thr Pro Val 
65                  70                  75                  80  


Met Leu Met Ser Phe Leu Arg Lys Glu Thr Ser Leu Pro Val Ala Gly 
                85                  90                  95      


Cys Val Ala Gln Leu Cys Ser Val Val Thr Phe Gly Thr Ala Glu Cys 
            100                 105                 110         


Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser 
        115                 120                 125             


Pro Leu Leu Tyr Ser Thr Cys Met Ser Pro Gly Val Cys Ile Ile Leu 
    130                 135                 140                 


Val Gly Met Ser Tyr Leu Gly Gly Cys Val Asn Ala Trp Thr Phe Ile 
145                 150                 155                 160 


Gly Cys Leu Leu Arg Leu Ser Phe Cys Gly Pro Asn Lys Val Asn His 
                165                 170                 175     


Phe Phe Cys Asp Tyr Ser Pro Leu Leu Lys Leu Ala Cys Ser His Asp 
            180                 185                 190         


Phe Thr Phe Glu Ile Ile Pro Ala Ile Ser Ser Gly Ser Ile Ile Val 
        195                 200                 205             


Ala Thr Val Cys Val Ile Ala Ile Ser Tyr Ile Tyr Ile Leu Ile Thr 
    210                 215                 220                 


Ile Leu Lys Met His Ser Thr Lys Gly Arg His Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Thr Ser His Leu Thr Ala Val Thr Leu Phe Tyr Gly Thr Ile Thr 
                245                 250                 255     


Phe Ile Tyr Val Met Pro Lys Ser Ser Tyr Ser Thr Asp Gln Asn Lys 
            260                 265                 270         


Val Val Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro Leu 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys Gly Ala Leu Lys Arg Glu 
    290                 295                 300                 


Leu Arg Ile Lys Ile Phe Ser 
305                 310     


<210>  6193
<211>  566
<212>  PRT
<213>  Homo sapiens

<400>  6193

Met Gly Ser Ala Gly Phe Ser Val Gly Lys Phe His Val Glu Val Ala 
1               5                   10                  15      


Ser Arg Gly Arg Glu Cys Val Ser Gly Thr Pro Glu Cys Gly Asn Arg 
            20                  25                  30          


Leu Gly Ser Ala Gly Phe Gly Ala Leu Cys Leu Glu Leu Arg Gly Ala 
        35                  40                  45              


Asp Pro Ala Trp Gly Pro Phe Ala Ala His Gly Arg Ser Arg Arg Gln 
    50                  55                  60                  


Gly Ser Arg Phe Leu Trp Leu Leu Lys Ile Leu Val Ile Ile Leu Val 
65                  70                  75                  80  


Leu Gly Ile Val Gly Phe Met Phe Gly Ser Met Phe Leu Gln Ala Val 
                85                  90                  95      


Phe Ser Ser Pro Lys Pro Glu Leu Pro Ser Pro Ala Pro Gly Val Gln 
            100                 105                 110         


Lys Leu Lys Leu Leu Pro Glu Glu Arg Leu Arg Asn Leu Phe Ser Tyr 
        115                 120                 125             


Asp Gly Ile Trp Leu Phe Pro Lys Asn Gln Cys Lys Cys Glu Ala Asn 
    130                 135                 140                 


Lys Glu Gln Gly Gly Tyr Asn Phe Gln Asp Ala Tyr Gly Gln Ser Asp 
145                 150                 155                 160 


Leu Pro Ala Val Lys Ala Arg Arg Gln Ala Glu Phe Glu His Phe Gln 
                165                 170                 175     


Arg Arg Glu Gly Leu Pro Arg Pro Leu Pro Leu Leu Val Gln Pro Asn 
            180                 185                 190         


Leu Pro Phe Gly Tyr Pro Val His Gly Val Glu Val Met Pro Leu His 
        195                 200                 205             


Thr Val Pro Ile Pro Gly Leu Gln Phe Glu Gly Pro Asp Ala Pro Val 
    210                 215                 220                 


Tyr Glu Val Thr Leu Thr Ala Ser Leu Gly Thr Leu Asn Thr Leu Ala 
225                 230                 235                 240 


Asp Val Pro Asp Ser Val Val Gln Gly Arg Gly Gln Lys Gln Leu Ile 
                245                 250                 255     


Ile Ser Thr Ser Asp Arg Lys Leu Leu Lys Phe Ile Leu Gln His Val 
            260                 265                 270         


Thr Tyr Thr Ser Thr Gly Tyr Gln His Gln Lys Val Asp Ile Val Ser 
        275                 280                 285             


Leu Glu Ser Arg Ser Ser Val Ala Lys Phe Pro Val Thr Ile Arg His 
    290                 295                 300                 


Pro Val Ile Pro Lys Leu Tyr Asp Pro Gly Pro Glu Arg Lys Leu Arg 
305                 310                 315                 320 


Asn Leu Val Thr Ile Ala Thr Lys Thr Phe Leu Arg Pro His Lys Leu 
                325                 330                 335     


Met Ile Met Leu Arg Ser Ile Arg Glu Tyr Tyr Pro Asp Leu Thr Val 
            340                 345                 350         


Ile Val Ala Asp Asp Ser Gln Lys Pro Leu Glu Ile Lys Asp Asn His 
        355                 360                 365             


Val Glu Tyr Tyr Thr Met Pro Phe Gly Lys Gly Trp Phe Ala Gly Arg 
    370                 375                 380                 


Asn Leu Ala Ile Ser Gln Val Thr Thr Lys Tyr Val Leu Trp Val Asp 
385                 390                 395                 400 


Asp Asp Phe Leu Phe Asn Glu Glu Thr Lys Ile Glu Val Leu Val Asp 
                405                 410                 415     


Val Leu Glu Lys Thr Glu Leu Asp Val Val Gly Gly Ser Val Leu Gly 
            420                 425                 430         


Asn Val Phe Gln Phe Lys Leu Leu Leu Glu Gln Ser Glu Asn Gly Ala 
        435                 440                 445             


Cys Leu His Lys Arg Met Gly Phe Phe Gln Pro Leu Asp Gly Phe Pro 
    450                 455                 460                 


Ser Cys Val Val Thr Ser Gly Val Val Asn Phe Phe Leu Ala His Thr 
465                 470                 475                 480 


Glu Arg Leu Gln Arg Val Gly Phe Asp Pro Arg Leu Gln Arg Val Ala 
                485                 490                 495     


His Ser Glu Phe Phe Ile Asp Gly Leu Gly Thr Leu Leu Val Gly Ser 
            500                 505                 510         


Cys Pro Glu Val Ile Ile Gly His Gln Ser Arg Ser Pro Val Val Asp 
        515                 520                 525             


Ser Glu Leu Ala Ala Leu Glu Lys Thr Tyr Asn Thr Tyr Arg Ser Asn 
    530                 535                 540                 


Thr Leu Thr Arg Val Gln Phe Lys Leu Ala Leu His Tyr Phe Lys Asn 
545                 550                 555                 560 


His Leu Gln Cys Ala Ala 
                565     


<210>  6194
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  6194

Met Asp Glu Arg Phe Asn Lys Trp Leu Leu Thr Pro Val Leu Thr Leu 
1               5                   10                  15      


Leu Phe Val Val Ile Met Tyr Gln Tyr Val Ser Pro Ser Cys Thr Ser 
            20                  25                  30          


Ser Cys Thr Asn Phe Gly Glu Gln Pro Arg Ala Gly Glu Ala Gly Pro 
        35                  40                  45              


Pro Ala Val Pro Gly Pro Ala Arg Arg Ala Gln Ala Pro Pro Glu Glu 
    50                  55                  60                  


Trp Glu Arg Arg Pro Gln Leu Pro Pro Pro Pro Arg Gly Pro Pro Glu 
65                  70                  75                  80  


Gly Pro Arg Gly Ala Ala Ala Pro Glu Glu Glu Asp Glu Glu Pro Gly 
                85                  90                  95      


Asp Pro Arg Glu Gly Glu Glu Glu Glu Glu Glu Asp Glu Pro Asp Pro 
            100                 105                 110         


Glu Ala Pro Glu Asn Gly Ser Leu Pro Arg Phe Val Pro Arg Phe Asn 
        115                 120                 125             


Phe Ser Leu Lys Asp Leu Thr Arg Phe Val Asp Phe Asn Ile Lys Gly 
    130                 135                 140                 


Arg Asp Val Ile Val Phe Leu His Ile Gln Lys Thr Gly Gly Thr Thr 
145                 150                 155                 160 


Phe Gly Arg His Leu Val Lys Asn Ile Arg Leu Glu Gln Pro Cys Ser 
                165                 170                 175     


Cys Lys Ala Gly Gln Lys Lys Cys Thr Cys His Arg Pro Gly Lys Lys 
            180                 185                 190         


Glu Thr Trp Leu Phe Ser Arg Phe Ser Thr Gly Trp Ser Cys Gly Leu 
        195                 200                 205             


His Ala Asp Trp Thr Glu Leu Thr Asn Cys Val Pro Ala Ile Met Glu 
    210                 215                 220                 


Lys Lys Asp Cys Pro Arg Asn His Ser His Thr Arg Asn Phe Tyr Tyr 
225                 230                 235                 240 


Ile Thr Met Leu Arg Asp Pro Val Ser Arg Tyr Leu Ser Glu Trp Lys 
                245                 250                 255     


His Val Gln Arg Gly Ala Thr Trp Lys Thr Ser Leu His Met Cys Asp 
            260                 265                 270         


Gly Arg Ser Pro Thr Pro Asp Glu Leu Pro Thr Cys Tyr Pro Gly Asp 
        275                 280                 285             


Asp Trp Ser Gly Val Ser Leu Arg Glu Phe Met Asp Cys Thr Tyr Asn 
    290                 295                 300                 


Leu Ala Asn Asn Arg Gln Val Arg Met Leu Ala Asp Leu Ser Leu Val 
305                 310                 315                 320 


Gly Cys Tyr Asn Leu Thr Phe Met Asn Glu Ser Glu Arg Asn Thr Ile 
                325                 330                 335     


Leu Leu Gln Ser Ala Lys Asn Asn Leu Lys Asn Met Ala Phe Phe Gly 
            340                 345                 350         


Leu Thr Glu Phe Gln Arg Lys Thr Gln Phe Leu Phe Glu Arg Thr Phe 
        355                 360                 365             


Asn Leu Lys Phe Ile Ser Pro Phe Thr Gln Phe Asn Ile Thr Arg Ala 
    370                 375                 380                 


Ser Asn Val Glu Ile Asn Glu Gly Ala Arg Gln Arg Ile Glu Asp Leu 
385                 390                 395                 400 


Asn Phe Leu Asp Met Gln Leu Tyr Glu Tyr Ala Lys Asp Leu Phe Gln 
                405                 410                 415     


Gln Arg Tyr His His Thr Lys Gln Leu Glu His Gln Arg Asp Arg Gln 
            420                 425                 430         


Lys Arg Arg Glu Glu Arg Arg Leu Gln Arg Glu His Arg Asp His Gln 
        435                 440                 445             


Trp Pro Lys Glu Asp Gly Ala Ala Glu Gly Thr Val Thr Glu Asp Tyr 
    450                 455                 460                 


Asn Ser Gln Val Val Arg Trp 
465                 470     


<210>  6195
<211>  720
<212>  PRT
<213>  Homo sapiens

<400>  6195

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys 
        35                  40                  45              


Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr 
    50                  55                  60                  


His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys 
65                  70                  75                  80  


Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp 
                85                  90                  95      


Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly 
            100                 105                 110         


Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser 
        115                 120                 125             


Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val 
    130                 135                 140                 


Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr 
145                 150                 155                 160 


Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr 
                165                 170                 175     


Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro 
            180                 185                 190         


Asp Cys Arg Gly Leu Glu Val Trp Asn Ser Ile Pro Ser Cys Trp Ala 
        195                 200                 205             


Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu Val 
    210                 215                 220                 


Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn 
225                 230                 235                 240 


Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr Gly 
                245                 250                 255     


Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys 
            260                 265                 270         


Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile Cys 
        275                 280                 285             


Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala Ala 
    290                 295                 300                 


Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys 
305                 310                 315                 320 


Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp 
                325                 330                 335     


Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr Val 
            340                 345                 350         


Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu Cys 
        355                 360                 365             


Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp 
    370                 375                 380                 


Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr 
385                 390                 395                 400 


Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly 
                405                 410                 415     


Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly 
            420                 425                 430         


Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp 
        435                 440                 445             


Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile 
    450                 455                 460                 


His Lys Arg Trp Ala Leu Val Trp Leu Ala Cys Leu Leu Phe Ala Ala 
465                 470                 475                 480 


Ala Leu Ser Leu Ile Leu Leu Leu Lys Lys Asp His Ala Lys Gly Trp 
                485                 490                 495     


Leu Arg Leu Leu Lys Gln Asp Val Arg Ser Gly Ala Ala Ala Arg Gly 
            500                 505                 510         


Arg Ala Ala Leu Leu Leu Tyr Ser Ala Asp Asp Ser Gly Phe Glu Arg 
        515                 520                 525             


Leu Val Gly Ala Leu Ala Ser Ala Leu Cys Gln Leu Pro Leu Arg Val 
    530                 535                 540                 


Ala Val Asp Leu Trp Ser Arg Arg Glu Leu Ser Ala Gln Gly Pro Val 
545                 550                 555                 560 


Ala Trp Phe His Ala Gln Arg Arg Gln Thr Leu Gln Glu Gly Gly Val 
                565                 570                 575     


Val Val Leu Leu Phe Ser Pro Gly Ala Val Ala Leu Cys Ser Glu Trp 
            580                 585                 590         


Leu Gln Asp Gly Val Ser Gly Pro Gly Ala His Gly Pro His Asp Ala 
        595                 600                 605             


Phe Arg Ala Ser Leu Ser Cys Val Leu Pro Asp Phe Leu Gln Gly Arg 
    610                 615                 620                 


Ala Pro Gly Ser Tyr Val Gly Ala Cys Phe Asp Arg Leu Leu His Pro 
625                 630                 635                 640 


Asp Ala Val Pro Ala Leu Phe Arg Thr Val Pro Val Phe Thr Leu Pro 
                645                 650                 655     


Ser Gln Leu Pro Asp Phe Leu Gly Ala Leu Gln Gln Pro Arg Ala Pro 
            660                 665                 670         


Arg Ser Gly Arg Leu Gln Glu Arg Ala Glu Gln Val Ser Arg Ala Leu 
        675                 680                 685             


Gln Pro Ala Leu Asp Ser Tyr Phe His Pro Pro Gly Thr Pro Ala Pro 
    690                 695                 700                 


Gly Arg Gly Val Gly Pro Gly Ala Gly Pro Gly Ala Gly Asp Gly Thr 
705                 710                 715                 720 


<210>  6196
<211>  791
<212>  PRT
<213>  Homo sapiens

<400>  6196

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Val Ser Leu Glu Pro Trp Gly Asp Glu Glu Arg Leu Arg 
        35                  40                  45              


Val Gln Phe Leu Ala Gln Gln Ser Leu Ser Leu Ala Pro Val Thr Ala 
    50                  55                  60                  


Ala Thr Ala Arg Thr Ala Leu Ser Gly Leu Ser Gly Ala Asp Gly Arg 
65                  70                  75                  80  


Arg Glu Glu Arg Gly Arg Gly Lys Ser Trp Val Cys Leu Ser Leu Gly 
                85                  90                  95      


Gly Ser Gly Asn Thr Glu Pro Gln Lys Lys Gly Leu Ser Cys Arg Leu 
            100                 105                 110         


Trp Asp Ser Asp Ile Leu Cys Leu Pro Gly Asp Ile Val Pro Ala Pro 
        115                 120                 125             


Gly Pro Val Leu Ala Pro Thr His Leu Gln Thr Glu Leu Val Leu Arg 
    130                 135                 140                 


Cys Gln Lys Glu Thr Asp Cys Asp Leu Cys Leu Arg Val Ala Val His 
145                 150                 155                 160 


Leu Ala Val His Gly His Trp Glu Glu Pro Glu Asp Glu Glu Lys Phe 
                165                 170                 175     


Gly Gly Ala Ala Asp Ser Gly Val Glu Glu Pro Arg Asn Ala Ser Leu 
            180                 185                 190         


Gln Ala Gln Val Val Leu Ser Phe Gln Ala Tyr Pro Thr Ala Arg Cys 
        195                 200                 205             


Val Leu Leu Glu Val Gln Val Pro Ala Ala Leu Val Gln Phe Gly Gln 
    210                 215                 220                 


Ser Val Gly Ser Val Val Tyr Asp Cys Phe Glu Ala Ala Leu Gly Ser 
225                 230                 235                 240 


Glu Val Arg Ile Trp Ser Tyr Thr Gln Pro Arg Tyr Glu Lys Glu Leu 
                245                 250                 255     


Asn His Thr Gln Gln Leu Pro Asp Cys Arg Gly Leu Glu Val Trp Asn 
            260                 265                 270         


Ser Ile Pro Ser Cys Trp Ala Leu Pro Trp Leu Asn Val Ser Ala Asp 
        275                 280                 285             


Gly Asp Asn Val His Leu Val Leu Asn Val Ser Glu Glu Gln His Phe 
    290                 295                 300                 


Gly Leu Ser Leu Tyr Trp Asn Gln Val Gln Gly Pro Pro Lys Pro Arg 
305                 310                 315                 320 


Trp His Lys Asn Leu Thr Gly Pro Gln Ile Ile Thr Leu Asn His Thr 
                325                 330                 335     


Asp Leu Val Pro Cys Leu Cys Ile Gln Val Trp Pro Leu Glu Pro Asp 
            340                 345                 350         


Ser Val Arg Thr Asn Ile Cys Pro Phe Arg Glu Asp Pro Arg Ala His 
        355                 360                 365             


Gln Asn Leu Trp Gln Ala Ala Arg Leu Arg Leu Leu Thr Leu Gln Ser 
    370                 375                 380                 


Trp Leu Leu Asp Ala Pro Cys Ser Leu Pro Ala Glu Ala Ala Leu Cys 
385                 390                 395                 400 


Trp Arg Ala Pro Gly Gly Asp Pro Cys Gln Pro Leu Val Pro Pro Leu 
                405                 410                 415     


Ser Trp Glu Asn Val Thr Val Asp Lys Val Leu Glu Phe Pro Leu Leu 
            420                 425                 430         


Lys Gly His Pro Asn Leu Cys Val Gln Val Asn Ser Ser Glu Lys Leu 
        435                 440                 445             


Gln Leu Gln Glu Cys Leu Trp Ala Asp Ser Leu Gly Pro Leu Lys Asp 
    450                 455                 460                 


Asp Val Leu Leu Leu Glu Thr Arg Gly Pro Gln Asp Asn Arg Ser Leu 
465                 470                 475                 480 


Cys Ala Leu Glu Pro Ser Gly Cys Thr Ser Leu Pro Ser Lys Ala Ser 
                485                 490                 495     


Thr Arg Ala Ala Arg Leu Gly Glu Tyr Leu Leu Gln Asp Leu Gln Ser 
            500                 505                 510         


Gly Gln Cys Leu Gln Leu Trp Asp Asp Asp Leu Gly Ala Leu Trp Ala 
        515                 520                 525             


Cys Pro Met Asp Lys Tyr Ile His Lys Arg Trp Ala Leu Val Trp Leu 
    530                 535                 540                 


Ala Cys Leu Leu Phe Ala Ala Ala Leu Ser Leu Ile Leu Leu Leu Lys 
545                 550                 555                 560 


Lys Asp His Ala Lys Gly Trp Leu Arg Leu Leu Lys Gln Asp Val Arg 
                565                 570                 575     


Ser Gly Ala Ala Ala Arg Gly Arg Ala Ala Leu Leu Leu Tyr Ser Ala 
            580                 585                 590         


Asp Asp Ser Gly Phe Glu Arg Leu Val Gly Ala Leu Ala Ser Ala Leu 
        595                 600                 605             


Cys Gln Leu Pro Leu Arg Val Ala Val Asp Leu Trp Ser Arg Arg Glu 
    610                 615                 620                 


Leu Ser Ala Gln Gly Pro Val Ala Trp Phe His Ala Gln Arg Arg Gln 
625                 630                 635                 640 


Thr Leu Gln Glu Gly Gly Val Val Val Leu Leu Phe Ser Pro Gly Ala 
                645                 650                 655     


Val Ala Leu Cys Ser Glu Trp Leu Gln Asp Gly Val Ser Gly Pro Gly 
            660                 665                 670         


Ala His Gly Pro His Asp Ala Phe Arg Ala Ser Leu Ser Cys Val Leu 
        675                 680                 685             


Pro Asp Phe Leu Gln Gly Arg Ala Pro Gly Ser Tyr Val Gly Ala Cys 
    690                 695                 700                 


Phe Asp Arg Leu Leu His Pro Asp Ala Val Pro Ala Leu Phe Arg Thr 
705                 710                 715                 720 


Val Pro Val Phe Thr Leu Pro Ser Gln Leu Pro Asp Phe Leu Gly Ala 
                725                 730                 735     


Leu Gln Gln Pro Arg Ala Pro Arg Ser Gly Arg Leu Gln Glu Arg Ala 
            740                 745                 750         


Glu Gln Val Ser Arg Ala Leu Gln Pro Ala Leu Asp Ser Tyr Phe His 
        755                 760                 765             


Pro Pro Gly Thr Pro Ala Pro Gly Arg Gly Val Gly Pro Gly Ala Gly 
    770                 775                 780                 


Pro Gly Ala Gly Asp Gly Thr 
785                 790     


<210>  6197
<211>  667
<212>  PRT
<213>  Homo sapiens

<400>  6197

Met Gly Ser Ser Arg Leu Ala Ala Leu Leu Leu Pro Leu Leu Leu Ile 
1               5                   10                  15      


Val Ile Asp Leu Ser Asp Ser Ala Gly Ile Gly Phe Arg His Leu Pro 
            20                  25                  30          


His Trp Asn Thr Arg Cys Pro Leu Ala Ser His Thr Asp Asp Ser Phe 
        35                  40                  45              


Thr Gly Ser Ser Ala Tyr Ile Pro Cys Arg Thr Trp Trp Ala Leu Phe 
    50                  55                  60                  


Ser Thr Lys Pro Trp Cys Val Arg Val Trp His Cys Ser Arg Cys Leu 
65                  70                  75                  80  


Cys Gln His Leu Leu Ser Gly Gly Ser Gly Leu Gln Arg Gly Leu Phe 
                85                  90                  95      


His Leu Leu Val Gln Lys Ser Lys Lys Ser Ser Thr Phe Lys Phe Tyr 
            100                 105                 110         


Arg Arg His Lys Met Pro Ala Pro Ala Gln Arg Lys Leu Leu Pro Arg 
        115                 120                 125             


Arg His Leu Ser Glu Lys Ser His His Ile Ser Ile Pro Ser Pro Asp 
    130                 135                 140                 


Ile Ser His Lys Gly Leu Arg Ser Lys Arg Thr Gln Pro Ser Asp Pro 
145                 150                 155                 160 


Glu Thr Trp Glu Ser Leu Pro Arg Leu Asp Ser Gln Arg His Gly Gly 
                165                 170                 175     


Pro Glu Phe Ser Phe Asp Leu Leu Pro Glu Ala Arg Ala Ile Arg Val 
            180                 185                 190         


Thr Ile Ser Ser Gly Pro Glu Val Ser Val Arg Leu Cys His Gln Trp 
        195                 200                 205             


Ala Leu Glu Cys Glu Glu Leu Ser Ser Pro Tyr Asp Val Gln Lys Ile 
    210                 215                 220                 


Val Ser Gly Gly His Thr Val Glu Leu Pro Tyr Glu Phe Leu Leu Pro 
225                 230                 235                 240 


Cys Leu Cys Ile Glu Ala Ser Tyr Leu Gln Glu Asp Thr Val Arg Arg 
                245                 250                 255     


Lys Lys Cys Pro Phe Gln Ser Trp Pro Glu Ala Tyr Gly Ser Asp Phe 
            260                 265                 270         


Trp Lys Ser Val His Phe Thr Asp Tyr Ser Gln His Thr Gln Met Val 
        275                 280                 285             


Met Ala Leu Thr Leu Arg Cys Pro Leu Lys Leu Glu Ala Ala Leu Cys 
    290                 295                 300                 


Gln Arg His Asp Trp His Thr Leu Cys Lys Asp Leu Pro Asn Ala Thr 
305                 310                 315                 320 


Ala Arg Glu Ser Asp Gly Trp Tyr Val Leu Glu Lys Val Asp Leu His 
                325                 330                 335     


Pro Gln Leu Cys Phe Lys Phe Ser Phe Gly Asn Ser Ser His Val Glu 
            340                 345                 350         


Cys Pro His Gln Thr Gly Ser Leu Thr Ser Trp Asn Val Ser Met Asp 
        355                 360                 365             


Thr Gln Ala Gln Gln Leu Ile Leu His Phe Ser Ser Arg Met His Ala 
    370                 375                 380                 


Thr Phe Ser Ala Ala Trp Ser Leu Pro Gly Leu Gly Gln Asp Thr Leu 
385                 390                 395                 400 


Val Pro Pro Val Tyr Thr Val Ser Gln Ala Arg Gly Ser Ser Pro Val 
                405                 410                 415     


Ser Leu Asp Leu Ile Ile Pro Phe Leu Arg Pro Gly Cys Cys Val Leu 
            420                 425                 430         


Val Trp Arg Ser Asp Val Gln Phe Ala Trp Lys His Leu Leu Cys Pro 
        435                 440                 445             


Asp Val Ser Tyr Arg His Leu Gly Leu Leu Ile Leu Ala Leu Leu Ala 
    450                 455                 460                 


Leu Leu Thr Leu Leu Gly Val Val Leu Ala Leu Thr Cys Arg Arg Pro 
465                 470                 475                 480 


Gln Ser Gly Pro Gly Pro Ala Arg Pro Val Leu Leu Leu His Ala Ala 
                485                 490                 495     


Asp Ser Glu Ala Gln Arg Arg Leu Val Gly Ala Leu Ala Glu Leu Leu 
            500                 505                 510         


Arg Ala Ala Leu Gly Gly Gly Arg Asp Val Ile Val Asp Leu Trp Glu 
        515                 520                 525             


Gly Arg His Val Ala Arg Val Gly Pro Leu Pro Trp Leu Trp Ala Ala 
    530                 535                 540                 


Arg Thr Arg Val Ala Arg Glu Gln Gly Thr Val Leu Leu Leu Trp Ser 
545                 550                 555                 560 


Gly Ala Asp Leu Arg Pro Val Ser Gly Pro Asp Pro Arg Ala Ala Pro 
                565                 570                 575     


Leu Leu Ala Leu Leu His Ala Ala Pro Arg Pro Leu Leu Leu Leu Ala 
            580                 585                 590         


Tyr Phe Ser Arg Leu Cys Ala Lys Gly Asp Ile Pro Pro Pro Leu Arg 
        595                 600                 605             


Ala Leu Pro Arg Tyr Arg Leu Leu Arg Asp Leu Pro Arg Leu Leu Arg 
    610                 615                 620                 


Ala Leu Asp Ala Arg Pro Phe Ala Glu Ala Thr Ser Trp Gly Arg Leu 
625                 630                 635                 640 


Gly Ala Arg Gln Arg Arg Gln Ser Arg Leu Glu Leu Cys Ser Arg Leu 
                645                 650                 655     


Glu Arg Glu Ala Ala Arg Leu Ala Asp Leu Gly 
            660                 665         


<210>  6198
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  6198

Met Pro Ala Pro Ala Gln Arg Lys Leu Leu Pro Arg Arg His Leu Ser 
1               5                   10                  15      


Glu Lys Ser His His Ile Ser Ile Pro Ser Pro Asp Ile Ser His Lys 
            20                  25                  30          


Gly Leu Arg Ser Lys Arg Thr Gln Pro Ser Asp Pro Glu Thr Trp Glu 
        35                  40                  45              


Ser Leu Pro Arg Leu Asp Ser Gln Arg His Gly Gly Pro Glu Phe Ser 
    50                  55                  60                  


Phe Asp Leu Leu Pro Glu Ala Arg Ala Ile Arg Val Thr Ile Ser Ser 
65                  70                  75                  80  


Gly Pro Glu Val Ser Val Arg Leu Cys His Gln Trp Ala Leu Glu Cys 
                85                  90                  95      


Glu Glu Leu Ser Ser Pro Tyr Asp Val Gln Lys Ile Val Ser Gly Gly 
            100                 105                 110         


His Thr Val Glu Leu Pro Tyr Glu Phe Leu Leu Pro Cys Leu Cys Ile 
        115                 120                 125             


Glu Ala Ser Tyr Leu Gln Glu Asp Thr Val Arg Arg Lys Lys Cys Pro 
    130                 135                 140                 


Phe Gln Ser Trp Pro Glu Ala Tyr Gly Ser Asp Phe Trp Lys Ser Val 
145                 150                 155                 160 


His Phe Thr Asp Tyr Ser Gln His Thr Gln Met Val Met Ala Leu Thr 
                165                 170                 175     


Leu Arg Cys Pro Leu Lys Leu Glu Ala Ala Leu Cys Gln Arg His Asp 
            180                 185                 190         


Trp His Thr Leu Cys Lys Asp Leu Pro Asn Ala Thr Ala Arg Glu Ser 
        195                 200                 205             


Asp Gly Trp Tyr Val Leu Glu Lys Val Asp Leu His Pro Gln Leu Cys 
    210                 215                 220                 


Phe Lys Phe Ser Phe Gly Asn Ser Ser His Val Glu Cys Pro His Gln 
225                 230                 235                 240 


Thr Gly Ser Leu Thr Ser Trp Asn Val Ser Met Asp Thr Gln Ala Gln 
                245                 250                 255     


Gln Leu Ile Leu His Phe Ser Ser Arg Met His Ala Thr Phe Ser Ala 
            260                 265                 270         


Ala Trp Ser Leu Pro Gly Leu Gly Gln Asp Thr Leu Val Pro Pro Val 
        275                 280                 285             


Tyr Thr Val Ser Gln Ala Arg Gly Ser Ser Pro Val Ser Leu Asp Leu 
    290                 295                 300                 


Ile Ile Pro Phe Leu Arg Pro Gly Cys Cys Val Leu Val Trp Arg Ser 
305                 310                 315                 320 


Asp Val Gln Phe Ala Trp Lys His Leu Leu Cys Pro Asp Val Ser Tyr 
                325                 330                 335     


Arg His Leu Gly Leu Leu Ile Leu Ala Leu Leu Ala Leu Leu Thr Leu 
            340                 345                 350         


Leu Gly Val Val Leu Ala Leu Thr Cys Arg Arg Pro Gln Ser Gly Pro 
        355                 360                 365             


Gly Pro Ala Arg Pro Val Leu Leu Leu His Ala Ala Asp Ser Glu Ala 
    370                 375                 380                 


Gln Arg Arg Leu Val Gly Ala Leu Ala Glu Leu Leu Arg Ala Ala Leu 
385                 390                 395                 400 


Gly Gly Gly Arg Asp Val Ile Val Asp Leu Trp Glu Gly Arg His Val 
                405                 410                 415     


Ala Arg Val Gly Pro Leu Pro Trp Leu Trp Ala Ala Arg Thr Arg Val 
            420                 425                 430         


Ala Arg Glu Gln Gly Thr Val Leu Leu Leu Trp Ser Gly Ala Asp Leu 
        435                 440                 445             


Arg Pro Val Ser Gly Pro Asp Pro Arg Ala Ala Pro Leu Leu Ala Leu 
    450                 455                 460                 


Leu His Ala Ala Pro Arg Pro Leu Leu Leu Leu Ala Tyr Phe Ser Arg 
465                 470                 475                 480 


Leu Cys Ala Lys Gly Asp Ile Pro Pro Pro Leu Arg Ala Leu Pro Arg 
                485                 490                 495     


Tyr Arg Leu Leu Arg Asp Leu Pro Arg Leu Leu Arg Ala Leu Asp Ala 
            500                 505                 510         


Arg Pro Phe Ala Glu Ala Thr Ser Trp Gly Arg Leu Gly Ala Arg Gln 
        515                 520                 525             


Arg Arg Gln Ser Arg Leu Glu Leu Cys Ser Arg Leu Glu Arg Glu Ala 
    530                 535                 540                 


Ala Arg Leu Ala Asp Leu Gly 
545                 550     


<210>  6199
<211>  707
<212>  PRT
<213>  Homo sapiens

<400>  6199

Met Gly Ala Ser Pro Asn Leu Met Leu Ala Pro Phe Leu Leu Leu Leu 
1               5                   10                  15      


Thr His Ser Arg Ser Pro Leu Ser Phe Arg Pro Cys Ser His Val Pro 
            20                  25                  30          


Gly Ala Leu Ile Ala Gln Lys Pro Met Gly Ser Ser Arg Leu Ala Ala 
        35                  40                  45              


Leu Leu Leu Pro Leu Leu Leu Ile Val Ile Asp Leu Ser Asp Ser Ala 
    50                  55                  60                  


Gly Ile Gly Phe Arg His Leu Pro His Trp Asn Thr Arg Cys Pro Leu 
65                  70                  75                  80  


Ala Ser His Thr Asp Asp Ser Phe Thr Gly Ser Ser Ala Tyr Ile Pro 
                85                  90                  95      


Cys Arg Thr Trp Trp Ala Leu Phe Ser Thr Lys Pro Trp Cys Val Arg 
            100                 105                 110         


Val Trp His Cys Ser Arg Cys Leu Cys Gln His Leu Leu Ser Gly Gly 
        115                 120                 125             


Ser Gly Leu Gln Arg Gly Leu Phe His Leu Leu Val Gln Lys Ser Lys 
    130                 135                 140                 


Lys Ser Ser Thr Phe Lys Phe Tyr Arg Arg His Lys Met Pro Ala Pro 
145                 150                 155                 160 


Ala Gln Arg Lys Leu Leu Pro Arg Arg His Leu Ser Glu Lys Ser His 
                165                 170                 175     


His Ile Ser Ile Pro Ser Pro Asp Ile Ser His Lys Gly Leu Arg Ser 
            180                 185                 190         


Lys Arg Thr Gln Pro Ser Asp Pro Glu Thr Trp Glu Ser Leu Pro Arg 
        195                 200                 205             


Leu Asp Ser Gln Arg His Gly Gly Pro Glu Phe Ser Phe Asp Leu Leu 
    210                 215                 220                 


Pro Glu Ala Arg Ala Ile Arg Val Thr Ile Ser Ser Gly Pro Glu Val 
225                 230                 235                 240 


Ser Val Arg Leu Cys His Gln Trp Ala Leu Glu Cys Glu Glu Leu Ser 
                245                 250                 255     


Ser Pro Tyr Asp Val Gln Lys Ile Val Ser Gly Gly His Thr Val Glu 
            260                 265                 270         


Leu Pro Tyr Glu Phe Leu Leu Pro Cys Leu Cys Ile Glu Ala Ser Tyr 
        275                 280                 285             


Leu Gln Glu Asp Thr Val Arg Arg Lys Lys Cys Pro Phe Gln Ser Trp 
    290                 295                 300                 


Pro Glu Ala Tyr Gly Ser Asp Phe Trp Lys Ser Val His Phe Thr Asp 
305                 310                 315                 320 


Tyr Ser Gln His Thr Gln Met Val Met Ala Leu Thr Leu Arg Cys Pro 
                325                 330                 335     


Leu Lys Leu Glu Ala Ala Leu Cys Gln Arg His Asp Trp His Thr Leu 
            340                 345                 350         


Cys Lys Asp Leu Pro Asn Ala Thr Ala Arg Glu Ser Asp Gly Trp Tyr 
        355                 360                 365             


Val Leu Glu Lys Val Asp Leu His Pro Gln Leu Cys Phe Lys Phe Ser 
    370                 375                 380                 


Phe Gly Asn Ser Ser His Val Glu Cys Pro His Gln Thr Gly Ser Leu 
385                 390                 395                 400 


Thr Ser Trp Asn Val Ser Met Asp Thr Gln Ala Gln Gln Leu Ile Leu 
                405                 410                 415     


His Phe Ser Ser Arg Met His Ala Thr Phe Ser Ala Ala Trp Ser Leu 
            420                 425                 430         


Pro Gly Leu Gly Gln Asp Thr Leu Val Pro Pro Val Tyr Thr Val Ser 
        435                 440                 445             


Gln Ala Arg Gly Ser Ser Pro Val Ser Leu Asp Leu Ile Ile Pro Phe 
    450                 455                 460                 


Leu Arg Pro Gly Cys Cys Val Leu Val Trp Arg Ser Asp Val Gln Phe 
465                 470                 475                 480 


Ala Trp Lys His Leu Leu Cys Pro Asp Val Ser Tyr Arg His Leu Gly 
                485                 490                 495     


Leu Leu Ile Leu Ala Leu Leu Ala Leu Leu Thr Leu Leu Gly Val Val 
            500                 505                 510         


Leu Ala Leu Thr Cys Arg Arg Pro Gln Ser Gly Pro Gly Pro Ala Arg 
        515                 520                 525             


Pro Val Leu Leu Leu His Ala Ala Asp Ser Glu Ala Gln Arg Arg Leu 
    530                 535                 540                 


Val Gly Ala Leu Ala Glu Leu Leu Arg Ala Ala Leu Gly Gly Gly Arg 
545                 550                 555                 560 


Asp Val Ile Val Asp Leu Trp Glu Gly Arg His Val Ala Arg Val Gly 
                565                 570                 575     


Pro Leu Pro Trp Leu Trp Ala Ala Arg Thr Arg Val Ala Arg Glu Gln 
            580                 585                 590         


Gly Thr Val Leu Leu Leu Trp Ser Gly Ala Asp Leu Arg Pro Val Ser 
        595                 600                 605             


Gly Pro Asp Pro Arg Ala Ala Pro Leu Leu Ala Leu Leu His Ala Ala 
    610                 615                 620                 


Pro Arg Pro Leu Leu Leu Leu Ala Tyr Phe Ser Arg Leu Cys Ala Lys 
625                 630                 635                 640 


Gly Asp Ile Pro Pro Pro Leu Arg Ala Leu Pro Arg Tyr Arg Leu Leu 
                645                 650                 655     


Arg Asp Leu Pro Arg Leu Leu Arg Ala Leu Asp Ala Arg Pro Phe Ala 
            660                 665                 670         


Glu Ala Thr Ser Trp Gly Arg Leu Gly Ala Arg Gln Arg Arg Gln Ser 
        675                 680                 685             


Arg Leu Glu Leu Cys Ser Arg Leu Glu Arg Glu Ala Ala Arg Leu Ala 
    690                 695                 700                 


Asp Leu Gly 
705         


<210>  6200
<211>  811
<212>  PRT
<213>  Homo sapiens

<400>  6200

Met Leu Leu Leu Phe His Ser Lys Arg Met Pro Val Ala Glu Ala Pro 
1               5                   10                  15      


Gln Val Ala Gly Gly Gln Gly Asp Gly Gly Asp Gly Glu Glu Ala Glu 
            20                  25                  30          


Pro Glu Gly Met Phe Lys Ala Cys Glu Asp Ser Lys Arg Lys Ala Arg 
        35                  40                  45              


Gly Tyr Leu Arg Leu Val Pro Leu Phe Val Leu Leu Ala Leu Leu Val 
    50                  55                  60                  


Leu Ala Ser Ala Gly Val Leu Leu Trp Tyr Phe Leu Gly Tyr Lys Ala 
65                  70                  75                  80  


Glu Val Met Val Ser Gln Val Tyr Ser Gly Ser Leu Arg Val Leu Asn 
                85                  90                  95      


Arg His Phe Ser Gln Asp Leu Thr Arg Arg Glu Ser Ser Ala Phe Arg 
            100                 105                 110         


Ser Glu Thr Ala Lys Ala Gln Lys Met Leu Lys Glu Leu Ile Thr Ser 
        115                 120                 125             


Thr Arg Leu Gly Thr Tyr Tyr Asn Ser Ser Ser Val Tyr Ser Phe Gly 
    130                 135                 140                 


Glu Gly Pro Leu Thr Cys Phe Phe Trp Phe Ile Leu Gln Ile Pro Glu 
145                 150                 155                 160 


His Arg Arg Leu Met Leu Ser Pro Glu Val Val Gln Ala Leu Leu Val 
                165                 170                 175     


Glu Glu Leu Leu Ser Thr Val Asn Ser Ser Ala Ala Val Pro Tyr Arg 
            180                 185                 190         


Ala Glu Tyr Glu Val Asp Pro Glu Gly Leu Val Ile Leu Glu Ala Ser 
        195                 200                 205             


Val Lys Asp Ile Ala Ala Leu Asn Ser Thr Leu Gly Cys Tyr Arg Tyr 
    210                 215                 220                 


Ser Tyr Val Gly Gln Gly Gln Val Leu Arg Leu Lys Gly Pro Asp His 
225                 230                 235                 240 


Leu Ala Ser Ser Cys Leu Trp His Leu Gln Gly Pro Lys Asp Leu Met 
                245                 250                 255     


Leu Lys Leu Arg Leu Glu Trp Thr Leu Ala Glu Cys Arg Asp Arg Leu 
            260                 265                 270         


Ala Met Tyr Asp Val Ala Gly Pro Leu Glu Lys Arg Leu Ile Thr Ser 
        275                 280                 285             


Val Tyr Gly Cys Ser Arg Gln Glu Pro Val Val Glu Val Leu Ala Ser 
    290                 295                 300                 


Gly Ala Ile Met Ala Val Val Trp Lys Lys Gly Leu His Ser Tyr Tyr 
305                 310                 315                 320 


Asp Pro Phe Val Leu Ser Val Gln Pro Val Val Phe Gln Ala Cys Glu 
                325                 330                 335     


Val Asn Leu Thr Leu Asp Asn Arg Leu Asp Ser Gln Gly Val Leu Ser 
            340                 345                 350         


Thr Pro Tyr Phe Pro Ser Tyr Tyr Ser Pro Gln Thr His Cys Ser Trp 
        355                 360                 365             


His Leu Thr Val Pro Ser Leu Asp Tyr Gly Leu Ala Leu Trp Phe Asp 
    370                 375                 380                 


Ala Tyr Ala Leu Arg Arg Gln Lys Tyr Asp Leu Pro Cys Thr Gln Gly 
385                 390                 395                 400 


Gln Trp Thr Ile Gln Asn Arg Arg Leu Cys Gly Leu Arg Ile Leu Gln 
                405                 410                 415     


Pro Tyr Ala Glu Arg Ile Pro Val Val Ala Thr Ala Gly Ile Thr Ile 
            420                 425                 430         


Asn Phe Thr Ser Gln Ile Ser Leu Thr Gly Pro Gly Val Arg Val His 
        435                 440                 445             


Tyr Gly Leu Tyr Asn Gln Ser Asp Pro Cys Pro Gly Glu Phe Leu Cys 
    450                 455                 460                 


Ser Val Asn Gly Leu Cys Val Pro Ala Cys Asp Gly Val Lys Asp Cys 
465                 470                 475                 480 


Pro Asn Gly Leu Asp Glu Arg Asn Cys Val Cys Arg Ala Thr Phe Gln 
                485                 490                 495     


Cys Lys Glu Asp Ser Thr Cys Ile Ser Leu Pro Lys Val Cys Asp Gly 
            500                 505                 510         


Gln Pro Asp Cys Leu Asn Gly Ser Asp Glu Glu Gln Cys Gln Glu Gly 
        515                 520                 525             


Val Pro Cys Gly Thr Phe Thr Phe Gln Cys Glu Asp Arg Ser Cys Val 
    530                 535                 540                 


Lys Lys Pro Asn Pro Gln Cys Asp Gly Arg Pro Asp Cys Arg Asp Gly 
545                 550                 555                 560 


Ser Asp Glu Glu His Cys Asp Cys Gly Leu Gln Gly Pro Ser Ser Arg 
                565                 570                 575     


Ile Val Gly Gly Ala Val Ser Ser Glu Gly Glu Trp Pro Trp Gln Ala 
            580                 585                 590         


Ser Leu Gln Val Arg Gly Arg His Ile Cys Gly Gly Ala Leu Ile Ala 
        595                 600                 605             


Asp Arg Trp Val Ile Thr Ala Ala His Cys Phe Gln Glu Asp Ser Met 
    610                 615                 620                 


Ala Ser Thr Val Leu Trp Thr Val Phe Leu Gly Lys Val Trp Gln Asn 
625                 630                 635                 640 


Ser Arg Trp Pro Gly Glu Val Ser Phe Lys Val Ser Arg Leu Leu Leu 
                645                 650                 655     


His Pro Tyr His Glu Glu Asp Ser His Asp Tyr Asp Val Ala Leu Leu 
            660                 665                 670         


Gln Leu Asp His Pro Val Val Arg Ser Ala Ala Val Arg Pro Val Cys 
        675                 680                 685             


Leu Pro Ala Arg Ser His Phe Phe Glu Pro Gly Leu His Cys Trp Ile 
    690                 695                 700                 


Thr Gly Trp Gly Ala Leu Arg Glu Gly Gly Pro Ile Ser Asn Ala Leu 
705                 710                 715                 720 


Gln Lys Val Asp Val Gln Leu Ile Pro Gln Asp Leu Cys Ser Glu Val 
                725                 730                 735     


Tyr Arg Tyr Gln Val Thr Pro Arg Met Leu Cys Ala Gly Tyr Arg Lys 
            740                 745                 750         


Gly Lys Lys Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys 
        755                 760                 765             


Lys Ala Leu Ser Gly Arg Trp Phe Leu Ala Gly Leu Val Ser Trp Gly 
    770                 775                 780                 


Leu Gly Cys Gly Arg Pro Asn Tyr Phe Gly Val Tyr Thr Arg Ile Thr 
785                 790                 795                 800 


Gly Val Ile Ser Trp Ile Gln Gln Val Val Thr 
                805                 810     


<210>  6201
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  6201

Met Val Ser Gly Arg Phe Tyr Leu Ser Cys Leu Leu Leu Gly Ser Leu 
1               5                   10                  15      


Gly Ser Met Cys Ile Leu Phe Thr Ile Tyr Trp Met Gln Tyr Trp Arg 
            20                  25                  30          


Gly Gly Phe Ala Trp Asn Gly Ser Ile Tyr Met Phe Asn Trp His Pro 
        35                  40                  45              


Val Leu Met Val Ala Gly Met Val Val Phe Tyr Gly Gly Ala Ser Leu 
    50                  55                  60                  


Val Tyr Arg Leu Pro Gln Ser Trp Val Gly Pro Lys Leu Pro Trp Lys 
65                  70                  75                  80  


Leu Leu His Ala Ala Leu His Leu Met Ala Phe Val Leu Thr Val Val 
                85                  90                  95      


Gly Leu Val Ala Val Phe Thr Phe His Asn His Gly Arg Thr Ala Asn 
            100                 105                 110         


Leu Tyr Ser Leu His Ser Trp Leu Gly Ile Thr Thr Val Phe Leu Phe 
        115                 120                 125             


Ala Cys Gln Trp Phe Leu Gly Phe Ala Val Phe Leu Leu Pro Trp Ala 
    130                 135                 140                 


Ser Met Trp Leu Arg Ser Leu Leu Lys Pro Ile His Val Phe Phe Gly 
145                 150                 155                 160 


Ala Ala Ile Leu Ser Leu Ser Ile Ala Ser Val Ile Ser Gly Ile Asn 
                165                 170                 175     


Glu Lys Leu Phe Phe Ser Leu Lys Asn Thr Thr Arg Pro Tyr His Ser 
            180                 185                 190         


Leu Pro Ser Glu Ala Val Phe Ala Asn Ser Thr Gly Met Leu Val Val 
        195                 200                 205             


Ala Phe Gly Leu Leu Val Leu Tyr Ile Leu Leu Ala Ser Ser Trp Lys 
    210                 215                 220                 


Arg Pro Glu Pro Gly Ile Leu Thr Asp Arg Gln Pro Leu Leu His Asp 
225                 230                 235                 240 


Gly Glu 
        


<210>  6202
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  6202

Met Leu Phe Lys Gln Gln Ala Trp Leu Arg Gln Lys Leu Leu Val Leu 
1               5                   10                  15      


Gly Ser Leu Ala Val Gly Ser Leu Leu Tyr Leu Val Ala Arg Val Gly 
            20                  25                  30          


Ser Leu Asp Arg Leu Gln Pro Ile Cys Pro Ile Glu Gly Arg Leu Gly 
        35                  40                  45              


Gly Ala Arg Thr Gln Ala Glu Phe Pro Leu Arg Ala Leu Gln Phe Lys 
    50                  55                  60                  


Arg Gly Leu Leu His Glu Phe Arg Lys Gly Asn Ala Ser Lys Glu Gln 
65                  70                  75                  80  


Val Arg Leu His Asp Leu Val Gln Gln Leu Pro Lys Ala Ile Ile Ile 
                85                  90                  95      


Gly Val Arg Lys Gly Gly Thr Arg Ala Leu Leu Glu Met Leu Asn Leu 
            100                 105                 110         


His Pro Ala Val Val Lys Ala Ser Gln Glu Ile His Phe Phe Asp Asn 
        115                 120                 125             


Asp Glu Asn Tyr Gly Lys Gly Ile Glu Trp Tyr Arg Lys Lys Met Pro 
    130                 135                 140                 


Phe Ser Tyr Pro Gln Gln Ile Thr Ile Glu Lys Ser Pro Ala Tyr Phe 
145                 150                 155                 160 


Ile Thr Glu Glu Val Pro Glu Arg Ile Tyr Lys Met Asn Ser Ser Ile 
                165                 170                 175     


Lys Leu Leu Ile Ile Val Arg Glu Pro Thr Thr Arg Ala Ile Ser Asp 
            180                 185                 190         


Tyr Thr Gln Val Leu Glu Gly Lys Glu Arg Lys Asn Lys Thr Tyr Tyr 
        195                 200                 205             


Lys Phe Glu Lys Leu Ala Ile Asp Pro Asn Thr Cys Glu Val Asn Thr 
    210                 215                 220                 


Lys Tyr Lys Ala Val Arg Thr Ser Ile Tyr Thr Lys His Leu Glu Arg 
225                 230                 235                 240 


Trp Leu Lys Tyr Phe Pro Ile Glu Gln Phe His Val Val Asp Gly Asp 
                245                 250                 255     


Arg Leu Ile Thr Glu Pro Leu Pro Glu Leu Gln Leu Val Glu Lys Phe 
            260                 265                 270         


Leu Asn Leu Pro Pro Arg Ile Ser Gln Tyr Asn Leu Tyr Phe Asn Ala 
        275                 280                 285             


Thr Arg Gly Phe Tyr Cys Leu Arg Phe Asn Ile Ile Phe Asn Lys Cys 
    290                 295                 300                 


Leu Ala Gly Ser Lys Gly Arg Ile His Pro Glu Val Asp Pro Ser Val 
305                 310                 315                 320 


Ile Thr Lys Leu Arg Lys Phe Phe His Pro Phe Asn Gln Lys Phe Tyr 
                325                 330                 335     


Gln Ile Thr Gly Arg Thr Leu Asn Trp Pro 
            340                 345     


<210>  6203
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  6203

Met Ser Gln Gly Ser Pro Gly Asp Trp Ala Pro Leu Asp Pro Thr Pro 
1               5                   10                  15      


Gly Pro Pro Ala Ser Pro Asn Pro Phe Val His Glu Leu His Leu Ser 
            20                  25                  30          


Arg Leu Gln Arg Val Lys Phe Cys Leu Leu Gly Ala Leu Leu Ala Pro 
        35                  40                  45              


Ile Arg Val Leu Leu Ala Phe Ile Val Leu Phe Leu Leu Trp Pro Phe 
    50                  55                  60                  


Ala Trp Leu Gln Val Ala Gly Leu Ser Glu Glu Gln Leu Gln Glu Pro 
65                  70                  75                  80  


Ile Thr Gly Trp Arg Lys Thr Val Cys His Asn Gly Val Leu Gly Leu 
                85                  90                  95      


Ser Arg Leu Leu Phe Phe Leu Leu Gly Phe Leu Arg Ile Arg Val Arg 
            100                 105                 110         


Gly Gln Arg Ala Ser Arg Leu Gln Ala Pro Val Leu Val Ala Ala Pro 
        115                 120                 125             


His Ser Thr Phe Phe Asp Pro Ile Val Leu Leu Pro Cys Asp Leu Pro 
    130                 135                 140                 


Lys Val Val Ser Arg Ala Glu Asn Leu Ser Val Pro Val Ile Gly Ala 
145                 150                 155                 160 


Leu Leu Arg Phe Asn Gln Ala Ile Leu Val Ser Arg His Asp Pro Ala 
                165                 170                 175     


Ser Arg Arg Arg Val Val Glu Glu Val Arg Arg Arg Ala Thr Ser Gly 
            180                 185                 190         


Gly Lys Trp Pro Gln Val Leu Phe Phe Pro Glu Gly Thr Cys Ser Asn 
        195                 200                 205             


Lys Lys Ala Leu Leu Lys Phe Lys Pro Gly Ala Phe Ile Ala Gly Val 
    210                 215                 220                 


Pro Val Gln Pro Val Leu Ile Arg Tyr Pro Asn Ser Leu Asp Thr Thr 
225                 230                 235                 240 


Ser Trp Ala Trp Arg Gly Pro Gly Val Leu Lys Val Leu Trp Leu Thr 
                245                 250                 255     


Ala Ser Gln Pro Cys Ser Ile Val Asp Val Glu Phe Leu Pro Val Tyr 
            260                 265                 270         


His Pro Ser Pro Glu Glu Ser Arg Asp Pro Thr Leu Tyr Ala Asn Asn 
        275                 280                 285             


Val Gln Arg Val Met Ala Gln Ala Leu Gly Ile Pro Ala Thr Glu Cys 
    290                 295                 300                 


Glu Phe Val Gly Ser Leu Pro Val Ile Val Val Gly Arg Leu Lys Val 
305                 310                 315                 320 


Ala Leu Glu Pro Gln Leu Trp Glu Leu Gly Lys Val Leu Arg Lys Ala 
                325                 330                 335     


Gly Leu Ser Ala Gly Tyr Val Asp Ala Gly Ala Glu Pro Gly Arg Ser 
            340                 345                 350         


Arg Met Ile Ser Gln Glu Glu Phe Ala Arg Gln Leu Gln Leu Ser Asp 
        355                 360                 365             


Pro Gln Thr Val Ala Gly Ala Phe Gly Tyr Phe Gln Gln Asp Thr Lys 
    370                 375                 380                 


Gly Leu Val Asp Phe Arg Asp Val Ala Leu Ala Leu Ala Ala Leu Asp 
385                 390                 395                 400 


Gly Gly Arg Ser Leu Glu Glu Leu Thr Arg Leu Ala Phe Glu Leu Phe 
                405                 410                 415     


Ala Glu Glu Gln Ala Glu Gly Pro Asn Arg Leu Leu Tyr Lys Asp Gly 
            420                 425                 430         


Phe Ser Thr Ile Leu His Leu Leu Leu Gly Ser Pro His Pro Ala Ala 
        435                 440                 445             


Thr Ala Leu His Ala Glu Leu Cys Gln Ala Gly Ser Ser Gln Gly Leu 
    450                 455                 460                 


Ser Leu Cys Gln Phe Gln Asn Phe Ser Leu His Asp Pro Leu Tyr Gly 
465                 470                 475                 480 


Lys Leu Phe Ser Thr Tyr Leu Arg Pro Pro His Thr Ser Arg Gly Thr 
                485                 490                 495     


Ser Gln Thr Pro Asn Ala Ser Ser Pro Gly Asn Pro Thr Ala Leu Ala 
            500                 505                 510         


Asn Gly Thr Val Gln Ala Pro Lys Gln Lys Gly Asp 
        515                 520                 


<210>  6204
<211>  998
<212>  PRT
<213>  Homo sapiens

<400>  6204

Met Arg Val Phe Leu Leu Cys Ala Tyr Ile Leu Leu Leu Met Val Ser 
1               5                   10                  15      


Gln Leu Arg Ala Val Ser Phe Pro Glu Asp Asp Glu Pro Leu Asn Thr 
            20                  25                  30          


Val Asp Tyr His Tyr Ser Arg Gln Tyr Pro Val Phe Arg Gly Arg Pro 
        35                  40                  45              


Ser Gly Asn Glu Ser Gln His Arg Leu Asp Phe Gln Leu Met Leu Lys 
    50                  55                  60                  


Ile Arg Asp Thr Leu Tyr Ile Ala Gly Arg Asp Gln Val Tyr Thr Val 
65                  70                  75                  80  


Asn Leu Asn Glu Met Pro Lys Thr Glu Val Ile Pro Asn Lys Lys Leu 
                85                  90                  95      


Thr Trp Arg Ser Arg Gln Gln Asp Arg Glu Asn Cys Ala Met Lys Gly 
            100                 105                 110         


Lys His Lys Asp Glu Cys His Asn Phe Ile Lys Val Phe Val Pro Arg 
        115                 120                 125             


Asn Asp Glu Met Val Phe Val Cys Gly Thr Asn Ala Phe Asn Pro Met 
    130                 135                 140                 


Cys Arg Tyr Tyr Arg Leu Ser Thr Leu Glu Tyr Asp Gly Glu Glu Ile 
145                 150                 155                 160 


Ser Gly Leu Ala Arg Cys Pro Phe Asp Ala Arg Gln Thr Asn Val Ala 
                165                 170                 175     


Leu Phe Ala Asp Gly Lys Leu Tyr Ser Ala Thr Val Ala Asp Phe Leu 
            180                 185                 190         


Ala Ser Asp Ala Val Ile Tyr Arg Ser Met Gly Asp Gly Ser Ala Leu 
        195                 200                 205             


Arg Thr Ile Lys Tyr Asp Ser Lys Trp Ile Lys Glu Pro His Phe Leu 
    210                 215                 220                 


His Ala Ile Glu Tyr Gly Asn Tyr Val Tyr Phe Phe Phe Arg Glu Ile 
225                 230                 235                 240 


Ala Val Glu His Asn Asn Leu Gly Lys Ala Val Tyr Ser Arg Val Ala 
                245                 250                 255     


Arg Ile Cys Lys Asn Asp Met Gly Gly Ser Gln Arg Val Leu Glu Lys 
            260                 265                 270         


His Trp Thr Ser Phe Leu Lys Ala Arg Leu Asn Cys Ser Val Pro Gly 
        275                 280                 285             


Asp Ser Phe Phe Tyr Phe Asp Val Leu Gln Ser Ile Thr Asp Ile Ile 
    290                 295                 300                 


Gln Ile Asn Gly Ile Pro Thr Val Val Gly Val Phe Thr Thr Gln Leu 
305                 310                 315                 320 


Asn Ser Ile Pro Gly Ser Ala Val Cys Ala Phe Ser Met Asp Asp Ile 
                325                 330                 335     


Glu Lys Val Phe Lys Gly Arg Phe Lys Glu Gln Lys Thr Pro Asp Ser 
            340                 345                 350         


Val Trp Thr Ala Val Pro Glu Asp Lys Val Pro Lys Pro Arg Pro Gly 
        355                 360                 365             


Cys Cys Ala Lys His Gly Leu Ala Glu Ala Tyr Lys Thr Ser Ile Asp 
    370                 375                 380                 


Phe Pro Asp Glu Thr Leu Ser Phe Ile Lys Ser His Pro Leu Met Asp 
385                 390                 395                 400 


Ser Ala Val Pro Pro Ile Ala Asp Glu Pro Trp Phe Thr Lys Thr Arg 
                405                 410                 415     


Val Arg Tyr Arg Leu Thr Ala Ile Ser Val Asp His Ser Ala Gly Pro 
            420                 425                 430         


Tyr Gln Asn Tyr Thr Val Ile Phe Val Gly Ser Glu Ala Gly Met Val 
        435                 440                 445             


Leu Lys Val Leu Ala Lys Thr Ser Pro Phe Ser Leu Asn Asp Ser Val 
    450                 455                 460                 


Leu Leu Glu Glu Ile Glu Ala Tyr Asn His Ala Lys Cys Ser Ala Glu 
465                 470                 475                 480 


Asn Glu Glu Asp Lys Lys Val Ile Ser Leu Gln Leu Asp Lys Asp His 
                485                 490                 495     


His Ala Leu Tyr Val Ala Phe Ser Ser Cys Ile Ile Arg Ile Pro Leu 
            500                 505                 510         


Ser Arg Cys Glu Arg Tyr Gly Ser Cys Lys Lys Ser Cys Ile Ala Ser 
        515                 520                 525             


Arg Asp Pro Tyr Cys Gly Trp Leu Ser Gln Gly Ser Cys Gly Arg Val 
    530                 535                 540                 


Thr Pro Gly Met Leu Ala Glu Gly Tyr Glu Gln Asp Thr Glu Phe Gly 
545                 550                 555                 560 


Asn Thr Ala His Leu Gly Asp Cys His Gly Val Arg Trp Glu Val Gln 
                565                 570                 575     


Ser Gly Glu Ser Asn Gln Met Val His Met Asn Val Leu Ile Thr Cys 
            580                 585                 590         


Val Phe Ala Ala Phe Val Leu Gly Ala Phe Ile Ala Gly Val Ala Val 
        595                 600                 605             


Tyr Cys Tyr Arg Asp Met Phe Val Arg Lys Asn Arg Lys Ile His Lys 
    610                 615                 620                 


Asp Ala Glu Ser Ala Gln Ser Cys Thr Asp Ser Ser Gly Ser Phe Ala 
625                 630                 635                 640 


Lys Leu Asn Gly Leu Phe Asp Ser Pro Val Lys Glu Tyr Gln Gln Asn 
                645                 650                 655     


Ile Asp Ser Pro Lys Leu Tyr Ser Asn Leu Leu Thr Ser Arg Lys Glu 
            660                 665                 670         


Leu Pro Pro Asn Gly Asp Thr Lys Ser Met Val Met Asp His Arg Gly 
        675                 680                 685             


Gln Pro Pro Glu Leu Ala Ala Leu Pro Thr Pro Glu Ser Thr Pro Val 
    690                 695                 700                 


Leu His Gln Lys Thr Leu Gln Ala Met Lys Ser His Ser Glu Lys Ala 
705                 710                 715                 720 


His Gly His Gly Ala Ser Arg Lys Glu Thr Pro Gln Phe Phe Pro Ser 
                725                 730                 735     


Ser Pro Pro Pro His Ser Pro Leu Ser His Gly His Ile Pro Ser Ala 
            740                 745                 750         


Ile Val Leu Pro Asn Ala Thr His Asp Tyr Asn Thr Ser Phe Ser Asn 
        755                 760                 765             


Ser Asn Ala His Lys Ala Glu Lys Lys Leu Gln Asn Ile Asp His Pro 
    770                 775                 780                 


Leu Thr Lys Ser Ser Ser Lys Arg Asp His Arg Arg Ser Val Asp Ser 
785                 790                 795                 800 


Arg Asn Thr Leu Asn Asp Leu Leu Lys His Leu Asn Asp Pro Asn Ser 
                805                 810                 815     


Asn Pro Lys Ala Ile Met Gly Asp Ile Gln Met Ala His Gln Asn Leu 
            820                 825                 830         


Met Leu Asp Pro Met Gly Ser Met Ser Glu Val Pro Pro Lys Val Pro 
        835                 840                 845             


Asn Arg Glu Ala Ser Leu Tyr Ser Pro Pro Ser Thr Leu Pro Arg Asn 
    850                 855                 860                 


Ser Pro Thr Lys Arg Val Asp Val Pro Thr Thr Pro Gly Val Pro Met 
865                 870                 875                 880 


Thr Ser Leu Glu Arg Gln Arg Gly Tyr His Lys Asn Ser Ser Gln Arg 
                885                 890                 895     


His Ser Ile Ser Ala Met Pro Lys Asn Leu Asn Ser Pro Asn Gly Val 
            900                 905                 910         


Leu Leu Ser Arg Gln Pro Ser Met Asn Arg Gly Gly Tyr Met Pro Thr 
        915                 920                 925             


Pro Thr Gly Ala Lys Val Asp Tyr Ile Gln Gly Thr Pro Val Ser Val 
    930                 935                 940                 


His Leu Gln Pro Ser Leu Ser Arg Gln Ser Ser Tyr Thr Ser Asn Gly 
945                 950                 955                 960 


Thr Leu Pro Arg Thr Gly Leu Lys Arg Thr Pro Ser Leu Lys Pro Asp 
                965                 970                 975     


Val Pro Pro Lys Pro Ser Phe Val Pro Gln Thr Pro Ser Val Arg Pro 
            980                 985                 990         


Leu Asn Lys Tyr Thr Tyr 
        995             


<210>  6205
<211>  1017
<212>  PRT
<213>  Homo sapiens

<400>  6205

Met Arg Val Phe Leu Leu Cys Ala Tyr Ile Leu Leu Leu Met Val Ser 
1               5                   10                  15      


Gln Leu Arg Ala Val Ser Phe Pro Glu Asp Asp Glu Pro Leu Asn Thr 
            20                  25                  30          


Val Asp Tyr His Tyr Ser Arg Gln Tyr Pro Val Phe Arg Gly Arg Pro 
        35                  40                  45              


Ser Gly Asn Glu Ser Gln His Arg Leu Asp Phe Gln Leu Met Leu Lys 
    50                  55                  60                  


Ile Arg Asp Thr Leu Tyr Ile Ala Gly Arg Asp Gln Val Tyr Thr Val 
65                  70                  75                  80  


Asn Leu Asn Glu Met Pro Lys Thr Glu Val Ile Pro Asn Lys Lys Leu 
                85                  90                  95      


Thr Trp Arg Ser Arg Gln Gln Asp Arg Glu Asn Cys Ala Met Lys Gly 
            100                 105                 110         


Lys His Lys Asp Glu Cys His Asn Phe Ile Lys Val Phe Val Pro Arg 
        115                 120                 125             


Asn Asp Glu Met Val Phe Val Cys Gly Thr Asn Ala Phe Asn Pro Met 
    130                 135                 140                 


Cys Arg Tyr Tyr Arg Leu Ser Thr Leu Glu Tyr Asp Gly Glu Glu Ile 
145                 150                 155                 160 


Ser Gly Leu Ala Arg Cys Pro Phe Asp Ala Arg Gln Thr Asn Val Ala 
                165                 170                 175     


Leu Phe Ala Asp Gly Lys Leu Tyr Ser Ala Thr Val Ala Asp Phe Leu 
            180                 185                 190         


Ala Ser Asp Ala Val Ile Tyr Arg Ser Met Gly Asp Gly Ser Ala Leu 
        195                 200                 205             


Arg Thr Ile Lys Tyr Asp Ser Lys Trp Ile Lys Glu Pro His Phe Leu 
    210                 215                 220                 


His Ala Ile Glu Tyr Gly Asn Tyr Val Tyr Phe Phe Phe Arg Glu Ile 
225                 230                 235                 240 


Ala Val Glu His Asn Asn Leu Gly Lys Ala Val Tyr Ser Arg Val Ala 
                245                 250                 255     


Arg Ile Cys Lys Asn Asp Met Gly Gly Ser Gln Arg Val Leu Glu Lys 
            260                 265                 270         


His Trp Thr Ser Phe Leu Lys Ala Arg Leu Asn Cys Ser Val Pro Gly 
        275                 280                 285             


Asp Ser Phe Phe Tyr Phe Asp Val Leu Gln Ser Ile Thr Asp Ile Ile 
    290                 295                 300                 


Gln Ile Asn Gly Ile Pro Thr Val Val Gly Val Phe Thr Thr Gln Leu 
305                 310                 315                 320 


Asn Ser Ile Pro Gly Ser Ala Val Cys Ala Phe Ser Met Asp Asp Ile 
                325                 330                 335     


Glu Lys Val Phe Lys Gly Arg Phe Lys Glu Gln Lys Thr Pro Asp Ser 
            340                 345                 350         


Val Trp Thr Ala Val Pro Glu Asp Lys Val Pro Lys Pro Arg Pro Gly 
        355                 360                 365             


Cys Cys Ala Lys His Gly Leu Ala Glu Ala Tyr Lys Thr Ser Ile Asp 
    370                 375                 380                 


Phe Pro Asp Glu Thr Leu Ser Phe Ile Lys Ser His Pro Leu Met Asp 
385                 390                 395                 400 


Ser Ala Val Pro Pro Ile Ala Asp Glu Pro Trp Phe Thr Lys Thr Arg 
                405                 410                 415     


Val Arg Tyr Arg Leu Thr Ala Ile Ser Val Asp His Ser Ala Gly Pro 
            420                 425                 430         


Tyr Gln Asn Tyr Thr Val Ile Phe Val Gly Ser Glu Ala Gly Met Val 
        435                 440                 445             


Leu Lys Val Leu Ala Lys Thr Ser Pro Phe Ser Leu Asn Asp Ser Val 
    450                 455                 460                 


Leu Leu Glu Glu Ile Glu Ala Tyr Asn His Ala Lys Cys Ser Ala Glu 
465                 470                 475                 480 


Asn Glu Glu Asp Lys Lys Val Ile Ser Leu Gln Leu Asp Lys Asp His 
                485                 490                 495     


His Ala Leu Tyr Val Ala Phe Ser Ser Cys Ile Ile Arg Ile Pro Leu 
            500                 505                 510         


Ser Arg Cys Glu Arg Tyr Gly Ser Cys Lys Lys Ser Cys Ile Ala Ser 
        515                 520                 525             


Arg Asp Pro Tyr Cys Gly Trp Leu Ser Gln Gly Ser Cys Gly Arg Val 
    530                 535                 540                 


Thr Pro Gly Met Leu Ala Glu Gly Tyr Glu Gln Asp Thr Glu Phe Gly 
545                 550                 555                 560 


Asn Thr Ala His Leu Gly Asp Cys His Glu Ile Leu Pro Thr Ser Thr 
                565                 570                 575     


Thr Pro Asp Tyr Lys Ile Phe Gly Gly Pro Thr Ser Gly Val Arg Trp 
            580                 585                 590         


Glu Val Gln Ser Gly Glu Ser Asn Gln Met Val His Met Asn Val Leu 
        595                 600                 605             


Ile Thr Cys Val Phe Ala Ala Phe Val Leu Gly Ala Phe Ile Ala Gly 
    610                 615                 620                 


Val Ala Val Tyr Cys Tyr Arg Asp Met Phe Val Arg Lys Asn Arg Lys 
625                 630                 635                 640 


Ile His Lys Asp Ala Glu Ser Ala Gln Ser Cys Thr Asp Ser Ser Gly 
                645                 650                 655     


Ser Phe Ala Lys Leu Asn Gly Leu Phe Asp Ser Pro Val Lys Glu Tyr 
            660                 665                 670         


Gln Gln Asn Ile Asp Ser Pro Lys Leu Tyr Ser Asn Leu Leu Thr Ser 
        675                 680                 685             


Arg Lys Glu Leu Pro Pro Asn Gly Asp Thr Lys Ser Met Val Met Asp 
    690                 695                 700                 


His Arg Gly Gln Pro Pro Glu Leu Ala Ala Leu Pro Thr Pro Glu Ser 
705                 710                 715                 720 


Thr Pro Val Leu His Gln Lys Thr Leu Gln Ala Met Lys Ser His Ser 
                725                 730                 735     


Glu Lys Ala His Gly His Gly Ala Ser Arg Lys Glu Thr Pro Gln Phe 
            740                 745                 750         


Phe Pro Ser Ser Pro Pro Pro His Ser Pro Leu Ser His Gly His Ile 
        755                 760                 765             


Pro Ser Ala Ile Val Leu Pro Asn Ala Thr His Asp Tyr Asn Thr Ser 
    770                 775                 780                 


Phe Ser Asn Ser Asn Ala His Lys Ala Glu Lys Lys Leu Gln Asn Ile 
785                 790                 795                 800 


Asp His Pro Leu Thr Lys Ser Ser Ser Lys Arg Asp His Arg Arg Ser 
                805                 810                 815     


Val Asp Ser Arg Asn Thr Leu Asn Asp Leu Leu Lys His Leu Asn Asp 
            820                 825                 830         


Pro Asn Ser Asn Pro Lys Ala Ile Met Gly Asp Ile Gln Met Ala His 
        835                 840                 845             


Gln Asn Leu Met Leu Asp Pro Met Gly Ser Met Ser Glu Val Pro Pro 
    850                 855                 860                 


Lys Val Pro Asn Arg Glu Ala Ser Leu Tyr Ser Pro Pro Ser Thr Leu 
865                 870                 875                 880 


Pro Arg Asn Ser Pro Thr Lys Arg Val Asp Val Pro Thr Thr Pro Gly 
                885                 890                 895     


Val Pro Met Thr Ser Leu Glu Arg Gln Arg Gly Tyr His Lys Asn Ser 
            900                 905                 910         


Ser Gln Arg His Ser Ile Ser Ala Met Pro Lys Asn Leu Asn Ser Pro 
        915                 920                 925             


Asn Gly Val Leu Leu Ser Arg Gln Pro Ser Met Asn Arg Gly Gly Tyr 
    930                 935                 940                 


Met Pro Thr Pro Thr Gly Ala Lys Val Asp Tyr Ile Gln Gly Thr Pro 
945                 950                 955                 960 


Val Ser Val His Leu Gln Pro Ser Leu Ser Arg Gln Ser Ser Tyr Thr 
                965                 970                 975     


Ser Asn Gly Thr Leu Pro Arg Thr Gly Leu Lys Arg Thr Pro Ser Leu 
            980                 985                 990         


Lys Pro Asp Val Pro Pro Lys Pro  Ser Phe Val Pro Gln  Thr Pro Ser 
        995                 1000                 1005             


Val Arg  Pro Leu Asn Lys Tyr  Thr Tyr 
    1010                 1015         


<210>  6206
<211>  1073
<212>  PRT
<213>  Homo sapiens

<400>  6206

Met Arg Val Phe Leu Leu Cys Ala Tyr Ile Leu Leu Leu Met Val Ser 
1               5                   10                  15      


Gln Leu Arg Ala Val Ser Phe Pro Glu Asp Asp Glu Pro Leu Asn Thr 
            20                  25                  30          


Val Asp Tyr His Tyr Ser Arg Gln Tyr Pro Val Phe Arg Gly Arg Pro 
        35                  40                  45              


Ser Gly Asn Glu Ser Gln His Arg Leu Asp Phe Gln Leu Met Leu Lys 
    50                  55                  60                  


Ile Arg Asp Thr Leu Tyr Ile Ala Gly Arg Asp Gln Val Tyr Thr Val 
65                  70                  75                  80  


Asn Leu Asn Glu Met Pro Lys Thr Glu Val Ile Pro Asn Lys Lys Leu 
                85                  90                  95      


Thr Trp Arg Ser Arg Gln Gln Asp Arg Glu Asn Cys Ala Met Lys Gly 
            100                 105                 110         


Lys His Lys Asp Glu Cys His Asn Phe Ile Lys Val Phe Val Pro Arg 
        115                 120                 125             


Asn Asp Glu Met Val Phe Val Cys Gly Thr Asn Ala Phe Asn Pro Met 
    130                 135                 140                 


Cys Arg Tyr Tyr Arg Leu Ser Thr Leu Glu Tyr Asp Gly Glu Glu Ile 
145                 150                 155                 160 


Ser Gly Leu Ala Arg Cys Pro Phe Asp Ala Arg Gln Thr Asn Val Ala 
                165                 170                 175     


Leu Phe Ala Asp Gly Lys Leu Tyr Ser Ala Thr Val Ala Asp Phe Leu 
            180                 185                 190         


Ala Ser Asp Ala Val Ile Tyr Arg Ser Met Gly Asp Gly Ser Ala Leu 
        195                 200                 205             


Arg Thr Ile Lys Tyr Asp Ser Lys Trp Ile Lys Glu Pro His Phe Leu 
    210                 215                 220                 


His Ala Ile Glu Tyr Gly Asn Tyr Val Tyr Phe Phe Phe Arg Glu Ile 
225                 230                 235                 240 


Ala Val Glu His Asn Asn Leu Gly Lys Ala Val Tyr Ser Arg Val Ala 
                245                 250                 255     


Arg Ile Cys Lys Asn Asp Met Gly Gly Ser Gln Arg Val Leu Glu Lys 
            260                 265                 270         


His Trp Thr Ser Phe Leu Lys Ala Arg Leu Asn Cys Ser Val Pro Gly 
        275                 280                 285             


Asp Ser Phe Phe Tyr Phe Asp Val Leu Gln Ser Ile Thr Asp Ile Ile 
    290                 295                 300                 


Gln Ile Asn Gly Ile Pro Thr Val Val Gly Val Phe Thr Thr Gln Leu 
305                 310                 315                 320 


Asn Ser Ile Pro Gly Ser Ala Val Cys Ala Phe Ser Met Asp Asp Ile 
                325                 330                 335     


Glu Lys Val Phe Lys Gly Arg Phe Lys Glu Gln Lys Thr Pro Asp Ser 
            340                 345                 350         


Val Trp Thr Ala Val Pro Glu Asp Lys Val Pro Lys Pro Arg Pro Gly 
        355                 360                 365             


Cys Cys Ala Lys His Gly Leu Ala Glu Ala Tyr Lys Thr Ser Ile Asp 
    370                 375                 380                 


Phe Pro Asp Glu Thr Leu Ser Phe Ile Lys Ser His Pro Leu Met Asp 
385                 390                 395                 400 


Ser Ala Val Pro Pro Ile Ala Asp Glu Pro Trp Phe Thr Lys Thr Arg 
                405                 410                 415     


Val Arg Tyr Arg Leu Thr Ala Ile Ser Val Asp His Ser Ala Gly Pro 
            420                 425                 430         


Tyr Gln Asn Tyr Thr Val Ile Phe Val Gly Ser Glu Ala Gly Met Val 
        435                 440                 445             


Leu Lys Val Leu Ala Lys Thr Ser Pro Phe Ser Leu Asn Asp Ser Val 
    450                 455                 460                 


Leu Leu Glu Glu Ile Glu Ala Tyr Asn His Ala Lys Cys Ser Ala Glu 
465                 470                 475                 480 


Asn Glu Glu Asp Lys Lys Val Ile Ser Leu Gln Leu Asp Lys Asp His 
                485                 490                 495     


His Ala Leu Tyr Val Ala Phe Ser Ser Cys Ile Ile Arg Ile Pro Leu 
            500                 505                 510         


Ser Arg Cys Glu Arg Tyr Gly Ser Cys Lys Lys Ser Cys Ile Ala Ser 
        515                 520                 525             


Arg Asp Pro Tyr Cys Gly Trp Leu Ser Gln Gly Ser Cys Gly Arg Val 
    530                 535                 540                 


Thr Pro Gly Met Leu Ala Glu Gly Tyr Glu Gln Asp Thr Glu Phe Gly 
545                 550                 555                 560 


Asn Thr Ala His Leu Gly Asp Cys His Glu Ile Leu Pro Thr Ser Thr 
                565                 570                 575     


Thr Pro Asp Tyr Lys Ile Phe Gly Gly Pro Thr Ser Asp Met Glu Val 
            580                 585                 590         


Ser Ser Ser Ser Val Thr Thr Met Ala Ser Ile Pro Glu Ile Thr Pro 
        595                 600                 605             


Lys Val Ile Asp Thr Trp Arg Pro Lys Leu Thr Ser Ser Arg Lys Phe 
    610                 615                 620                 


Val Val Gln Asp Asp Pro Asn Thr Ser Asp Phe Thr Asp Pro Leu Ser 
625                 630                 635                 640 


Gly Ile Pro Lys Gly Val Arg Trp Glu Val Gln Ser Gly Glu Ser Asn 
                645                 650                 655     


Gln Met Val His Met Asn Val Leu Ile Thr Cys Val Phe Ala Ala Phe 
            660                 665                 670         


Val Leu Gly Ala Phe Ile Ala Gly Val Ala Val Tyr Cys Tyr Arg Asp 
        675                 680                 685             


Met Phe Val Arg Lys Asn Arg Lys Ile His Lys Asp Ala Glu Ser Ala 
    690                 695                 700                 


Gln Ser Cys Thr Asp Ser Ser Gly Ser Phe Ala Lys Leu Asn Gly Leu 
705                 710                 715                 720 


Phe Asp Ser Pro Val Lys Glu Tyr Gln Gln Asn Ile Asp Ser Pro Lys 
                725                 730                 735     


Leu Tyr Ser Asn Leu Leu Thr Ser Arg Lys Glu Leu Pro Pro Asn Gly 
            740                 745                 750         


Asp Thr Lys Ser Met Val Met Asp His Arg Gly Gln Pro Pro Glu Leu 
        755                 760                 765             


Ala Ala Leu Pro Thr Pro Glu Ser Thr Pro Val Leu His Gln Lys Thr 
    770                 775                 780                 


Leu Gln Ala Met Lys Ser His Ser Glu Lys Ala His Gly His Gly Ala 
785                 790                 795                 800 


Ser Arg Lys Glu Thr Pro Gln Phe Phe Pro Ser Ser Pro Pro Pro His 
                805                 810                 815     


Ser Pro Leu Ser His Gly His Ile Pro Ser Ala Ile Val Leu Pro Asn 
            820                 825                 830         


Ala Thr His Asp Tyr Asn Thr Ser Phe Ser Asn Ser Asn Ala His Lys 
        835                 840                 845             


Ala Glu Lys Lys Leu Gln Asn Ile Asp His Pro Leu Thr Lys Ser Ser 
    850                 855                 860                 


Ser Lys Arg Asp His Arg Arg Ser Val Asp Ser Arg Asn Thr Leu Asn 
865                 870                 875                 880 


Asp Leu Leu Lys His Leu Asn Asp Pro Asn Ser Asn Pro Lys Ala Ile 
                885                 890                 895     


Met Gly Asp Ile Gln Met Ala His Gln Asn Leu Met Leu Asp Pro Met 
            900                 905                 910         


Gly Ser Met Ser Glu Val Pro Pro Lys Val Pro Asn Arg Glu Ala Ser 
        915                 920                 925             


Leu Tyr Ser Pro Pro Ser Thr Leu Pro Arg Asn Ser Pro Thr Lys Arg 
    930                 935                 940                 


Val Asp Val Pro Thr Thr Pro Gly Val Pro Met Thr Ser Leu Glu Arg 
945                 950                 955                 960 


Gln Arg Gly Tyr His Lys Asn Ser Ser Gln Arg His Ser Ile Ser Ala 
                965                 970                 975     


Met Pro Lys Asn Leu Asn Ser Pro Asn Gly Val Leu Leu Ser Arg Gln 
            980                 985                 990         


Pro Ser Met Asn Arg Gly Gly Tyr  Met Pro Thr Pro Thr  Gly Ala Lys 
        995                 1000                 1005             


Val Asp  Tyr Ile Gln Gly Thr  Pro Val Ser Val His  Leu Gln Pro 
    1010                 1015                 1020             


Ser Leu  Ser Arg Gln Ser Ser  Tyr Thr Ser Asn Gly  Thr Leu Pro 
    1025                 1030                 1035             


Arg Thr  Gly Leu Lys Arg Thr  Pro Ser Leu Lys Pro  Asp Val Pro 
    1040                 1045                 1050             


Pro Lys  Pro Ser Phe Val Pro  Gln Thr Pro Ser Val  Arg Pro Leu 
    1055                 1060                 1065             


Asn Lys  Tyr Thr Tyr 
    1070             


<210>  6207
<211>  597
<212>  PRT
<213>  Homo sapiens

<400>  6207

Met Arg Val Phe Leu Leu Cys Ala Tyr Ile Leu Leu Leu Met Val Ser 
1               5                   10                  15      


Gln Leu Arg Ala Val Ser Phe Pro Glu Asp Asp Glu Pro Leu Asn Thr 
            20                  25                  30          


Val Asp Tyr His Tyr Ser Arg Gln Tyr Pro Val Phe Arg Gly Arg Pro 
        35                  40                  45              


Ser Gly Asn Glu Ser Gln His Arg Leu Asp Phe Gln Leu Met Leu Lys 
    50                  55                  60                  


Ile Arg Asp Thr Leu Tyr Ile Ala Gly Arg Asp Gln Val Tyr Thr Val 
65                  70                  75                  80  


Asn Leu Asn Glu Met Pro Lys Thr Glu Val Ile Pro Asn Lys Lys Leu 
                85                  90                  95      


Thr Trp Arg Ser Arg Gln Gln Asp Arg Glu Asn Cys Ala Met Lys Gly 
            100                 105                 110         


Lys His Lys Asp Glu Cys His Asn Phe Ile Lys Val Phe Val Pro Arg 
        115                 120                 125             


Asn Asp Glu Met Val Phe Val Cys Gly Thr Asn Ala Phe Asn Pro Met 
    130                 135                 140                 


Cys Arg Tyr Tyr Arg Leu Ser Thr Leu Glu Tyr Asp Gly Glu Glu Ile 
145                 150                 155                 160 


Ser Gly Leu Ala Arg Cys Pro Phe Asp Ala Arg Gln Thr Asn Val Ala 
                165                 170                 175     


Leu Phe Ala Asp Gly Lys Leu Tyr Ser Ala Thr Val Ala Asp Phe Leu 
            180                 185                 190         


Ala Ser Asp Ala Val Ile Tyr Arg Ser Met Gly Asp Gly Ser Ala Leu 
        195                 200                 205             


Arg Thr Ile Lys Tyr Asp Ser Lys Trp Ile Lys Glu Pro His Phe Leu 
    210                 215                 220                 


His Ala Ile Glu Tyr Gly Asn Tyr Val Tyr Phe Phe Phe Arg Glu Ile 
225                 230                 235                 240 


Ala Val Glu His Asn Asn Leu Gly Lys Ala Val Tyr Ser Arg Val Ala 
                245                 250                 255     


Arg Ile Cys Lys Asn Asp Met Gly Gly Ser Gln Arg Val Leu Glu Lys 
            260                 265                 270         


His Trp Thr Ser Phe Leu Lys Ala Arg Leu Asn Cys Ser Val Pro Gly 
        275                 280                 285             


Asp Ser Phe Phe Tyr Phe Asp Val Leu Gln Ser Ile Thr Asp Ile Ile 
    290                 295                 300                 


Gln Ile Asn Gly Ile Pro Thr Val Val Gly Val Phe Thr Thr Gln Leu 
305                 310                 315                 320 


Asn Ser Ile Pro Gly Ser Ala Val Cys Ala Phe Ser Met Asp Asp Ile 
                325                 330                 335     


Glu Lys Val Phe Lys Gly Arg Phe Lys Glu Gln Lys Thr Pro Asp Ser 
            340                 345                 350         


Val Trp Thr Ala Val Pro Glu Asp Lys Val Pro Lys Pro Arg Pro Gly 
        355                 360                 365             


Cys Cys Ala Lys His Gly Leu Ala Glu Ala Tyr Lys Thr Ser Ile Asp 
    370                 375                 380                 


Phe Pro Asp Glu Thr Leu Ser Phe Ile Lys Ser His Pro Leu Met Asp 
385                 390                 395                 400 


Ser Ala Val Pro Pro Ile Ala Asp Glu Pro Trp Phe Thr Lys Thr Arg 
                405                 410                 415     


Val Arg Tyr Arg Leu Thr Ala Ile Ser Val Asp His Ser Ala Gly Pro 
            420                 425                 430         


Tyr Gln Asn Tyr Thr Val Ile Phe Val Gly Ser Glu Ala Gly Met Val 
        435                 440                 445             


Leu Lys Val Leu Ala Lys Thr Ser Pro Phe Ser Leu Asn Asp Ser Val 
    450                 455                 460                 


Leu Leu Glu Glu Ile Glu Ala Tyr Asn His Ala Lys Cys Ser Ala Glu 
465                 470                 475                 480 


Asn Glu Glu Asp Lys Lys Val Ile Ser Leu Gln Leu Asp Lys Asp His 
                485                 490                 495     


His Ala Leu Tyr Val Ala Phe Ser Ser Cys Ile Ile Arg Ile Pro Leu 
            500                 505                 510         


Ser Arg Cys Glu Arg Tyr Gly Ser Cys Lys Lys Ser Cys Ile Ala Ser 
        515                 520                 525             


Arg Asp Pro Tyr Cys Gly Trp Leu Ser Gln Gly Ser Cys Gly Arg Val 
    530                 535                 540                 


Thr Pro Gly Met Leu Ala Glu Gly Tyr Glu Gln Asp Thr Glu Phe Gly 
545                 550                 555                 560 


Asn Thr Ala His Leu Gly Asp Cys His Asp Met Glu Val Ser Ser Ser 
                565                 570                 575     


Ser Val Thr Thr Met Val Tyr Asp Gly Lys Ser Ser Leu Glu Ser Pro 
            580                 585                 590         


Thr Arg Trp Ser Thr 
        595         


<210>  6208
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  6208

Met Ala Ser Glu Glu Val Leu Lys Asn Arg Ala Ile Lys Lys Ala Lys 
1               5                   10                  15      


Arg Arg Asn Val Gly Phe Glu Ser Asp Thr Gly Gly Ala Phe Lys Gly 
            20                  25                  30          


Phe Lys Gly Leu Val Val Pro Ser Gly Gly Gly Arg Phe Ser Gly Phe 
        35                  40                  45              


Gly Ser Gly Ala Gly Gly Lys Pro Leu Glu Gly Leu Ser Asn Gly Asn 
    50                  55                  60                  


Asn Ile Thr Ser Ala Pro Pro Phe Ala Ser Ala Lys Ala Ala Ala Asp 
65                  70                  75                  80  


Pro Lys Val Ala Phe Gly Ser Leu Ala Ala Asn Gly Pro Thr Thr Leu 
                85                  90                  95      


Val Asp Lys Val Ser Asn Pro Lys Thr Asn Gly Asp Ser Gln Gln Pro 
            100                 105                 110         


Ser Ser Ser Gly Leu Ala Ser Ser Lys Ala Cys Val Gly Asn Ala Tyr 
        115                 120                 125             


His Lys Gln Leu Ala Ala Leu Asn Cys Ser Val Arg Asp Trp Ile Val 
    130                 135                 140                 


Lys His Val Asn Thr Asn Pro Leu Cys Asp Leu Thr Pro Ile Phe Lys 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Leu Ala Asn Ile Glu Gln Gln His Gly Asn Ser 
                165                 170                 175     


Gly Arg Asn Ser Glu Ser Glu Ser Asn Lys Val Ala Ala Glu Thr Gln 
            180                 185                 190         


Ser Pro Ser Leu Phe Gly Ser Thr Lys Leu Gln Gln Glu Ser Thr Phe 
        195                 200                 205             


Leu Phe His Gly Asn Lys Thr Glu Asp Thr Pro Asp Lys Lys Met Glu 
    210                 215                 220                 


Val Ala Ser Glu Lys Lys Thr Asp Pro Ser Ser Leu Gly Ala Thr Ser 
225                 230                 235                 240 


Ala Ser Phe Asn Phe Gly Lys Lys Val Asp Ser Ser Val Leu Gly Ser 
                245                 250                 255     


Leu Ser Ser Val Pro Leu Thr Gly Phe Ser Phe Ser Pro Gly Asn Ser 
            260                 265                 270         


Ser Leu Phe Gly Lys Asp Thr Thr Gln Ser Lys Pro Val Ser Ser Pro 
        275                 280                 285             


Phe Pro Thr Lys Pro Leu Glu Gly Gln Ala Glu Gly Asp Ser Gly Glu 
    290                 295                 300                 


Cys Lys Gly Gly Asp Glu Glu Glu Asn Asp Glu Pro Pro Lys Val Val 
305                 310                 315                 320 


Val Thr Glu Val Lys Glu Glu Asp Ala Phe Tyr Ser Lys Lys Cys Lys 
                325                 330                 335     


Leu Phe Tyr Lys Lys Asp Asn Glu Phe Lys Glu Lys Gly Ile Gly Thr 
            340                 345                 350         


Leu His Leu Lys Pro Thr Ala Asn Gln Lys Thr Gln Leu Leu Val Arg 
        355                 360                 365             


Ala Asp Thr Asn Leu Gly Asn Ile Leu Leu Asn Val Leu Ile Pro Pro 
    370                 375                 380                 


Asn Met Pro Cys Thr Arg Thr Gly Lys Asn Asn Val Leu Ile Val Cys 
385                 390                 395                 400 


Val Pro Asn Pro Pro Ile Asp Glu Lys Asn Ala Thr Met Pro Val Thr 
                405                 410                 415     


Met Leu Ile Arg Val Lys Thr Ser Glu Asp Ala Asp Glu Leu His Lys 
            420                 425                 430         


Ile Leu Leu Glu Lys Lys Asp Ala 
        435                 440 


<210>  6209
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  6209

Met Ala Leu Arg Gly Thr Leu Arg Pro Leu Lys Val Arg Arg Arg Arg 
1               5                   10                  15      


Glu Met Leu Pro Gln Gln Val Gly Phe Val Cys Ala Val Leu Ala Leu 
            20                  25                  30          


Val Cys Cys Ala Ser Gly Leu Phe Gly Ser Leu Gly His Lys Thr Ala 
        35                  40                  45              


Ser Ala Ser Lys Arg Val Leu Pro Asp Thr Trp Arg Asn Arg Lys Leu 
    50                  55                  60                  


Met Ala Pro Val Asn Gly Thr Gln Thr Ala Lys Asn Cys Thr Asp Pro 
65                  70                  75                  80  


Ala Ile His Glu Phe Pro Thr Asp Leu Phe Ser Asn Lys Glu Arg Gln 
                85                  90                  95      


His Gly Ala Val Leu Leu His Ile Leu Gly Ala Leu Tyr Met Phe Tyr 
            100                 105                 110         


Ala Leu Ala Ile Val Cys Asp Asp Phe Phe Val Pro Ser Leu Glu Lys 
        115                 120                 125             


Ile Cys Glu Arg Leu His Leu Ser Glu Asp Val Ala Gly Ala Thr Phe 
    130                 135                 140                 


Met Ala Ala Gly Ser Ser Thr Pro Glu Leu Phe Ala Ser Val Ile Gly 
145                 150                 155                 160 


Val Phe Ile Thr His Gly Asp Val Gly Val Gly Thr Ile Val Gly Ser 
                165                 170                 175     


Ala Val Phe Asn Ile Leu Cys Ile Ile Gly Val Cys Gly Leu Phe Ala 
            180                 185                 190         


Gly Gln Val Val Arg Leu Thr Trp Trp Ala Val Cys Arg Asp Ser Val 
        195                 200                 205             


Tyr Tyr Thr Ile Ser Val Ile Val Leu Ile Val Phe Ile Tyr Asp Glu 
    210                 215                 220                 


Gln Ile Val Trp Trp Glu Gly Leu Val Leu Ile Ile Leu Tyr Val Phe 
225                 230                 235                 240 


Tyr Ile Leu Ile Met Lys Tyr Asn Val Lys Met Gln Ala Phe Phe Thr 
                245                 250                 255     


Val Lys Gln Lys Ser Ile Ala Asn Gly Asn Pro Val Asn Ser Glu Leu 
            260                 265                 270         


Glu Ala Gly Asn Asp Phe Tyr Asp Gly Ser Tyr Asp Asp Pro Ser Val 
        275                 280                 285             


Pro Leu Leu Gly Gln Val Lys Glu Lys Pro Gln Tyr Gly Lys Asn Pro 
    290                 295                 300                 


Val Val Met Val Asp Glu Ile Met Ser Ser Ser Pro Pro Lys Phe Thr 
305                 310                 315                 320 


Phe Pro Glu Ala Gly Leu Arg Ile Met Ile Thr Asn Lys Phe Gly Pro 
                325                 330                 335     


Arg Thr Arg Leu Arg Met Ala Ser Arg Ile Ile Ile Asn Glu Arg Gln 
            340                 345                 350         


Arg Leu Ile Asn Ser Ala Asn Gly Val Ser Ser Lys Pro Leu Gln Asn 
        355                 360                 365             


Gly Arg His Glu Asn Ile Glu Asn Gly Asn Val Pro Val Glu Asn Pro 
    370                 375                 380                 


Glu Asp Pro Gln Gln Asn Gln Glu Gln Gln Pro Pro Pro Gln Pro Pro 
385                 390                 395                 400 


Pro Pro Glu Pro Glu Pro Val Glu Ala Asp Phe Leu Ser Pro Phe Ser 
                405                 410                 415     


Val Pro Glu Ala Arg Gly Asp Lys Val Lys Trp Val Phe Thr Trp Pro 
            420                 425                 430         


Leu Ile Phe Leu Leu Cys Val Thr Ile Pro Asn Cys Ser Lys Pro Arg 
        435                 440                 445             


Trp Glu Lys Phe Phe Met Val Thr Phe Ile Thr Ala Thr Leu Trp Ile 
    450                 455                 460                 


Ala Val Phe Ser Tyr Ile Met Val Trp Leu Val Thr Ile Ile Gly Tyr 
465                 470                 475                 480 


Thr Leu Gly Ile Pro Asp Val Ile Met Gly Ile Thr Phe Leu Ala Ala 
                485                 490                 495     


Gly Thr Ser Val Pro Asp Cys Met Ala Ser Leu Ile Val Ala Arg Gln 
            500                 505                 510         


Gly Leu Gly Asp Met Ala Val Ser Asn Thr Ile Gly Ser Asn Val Phe 
        515                 520                 525             


Asp Ile Leu Val Gly Leu Gly Val Pro Trp Gly Leu Gln Thr Met Val 
    530                 535                 540                 


Val Asn Tyr Gly Ser Thr Val Lys Ile Asn Ser Arg Gly Leu Val Tyr 
545                 550                 555                 560 


Ser Val Val Leu Leu Leu Gly Ser Val Ala Leu Thr Val Leu Gly Ile 
                565                 570                 575     


His Leu Asn Lys Trp Arg Leu Asp Arg Lys Leu Gly Val Tyr Val Leu 
            580                 585                 590         


Val Leu Tyr Ala Ile Phe Leu Cys Phe Ser Ile Met Ile Glu Phe Asn 
        595                 600                 605             


Val Phe Thr Phe Val Asn Leu Pro Met Cys Arg Glu Asp Asp 
    610                 615                 620         


<210>  6210
<211>  603
<212>  PRT
<213>  Homo sapiens

<400>  6210

Met Ala Leu Arg Gly Thr Leu Arg Pro Leu Lys Val Arg Arg Arg Arg 
1               5                   10                  15      


Glu Met Leu Pro Gln Gln Val Gly Phe Val Cys Ala Val Leu Ala Leu 
            20                  25                  30          


Val Cys Cys Ala Ser Gly Leu Phe Gly Ser Leu Gly His Lys Thr Ala 
        35                  40                  45              


Ser Ala Ser Lys Arg Val Leu Pro Asp Thr Trp Arg Asn Arg Lys Leu 
    50                  55                  60                  


Met Ala Pro Val Asn Gly Thr Gln Thr Ala Lys Asn Cys Thr Asp Pro 
65                  70                  75                  80  


Ala Ile His Glu Phe Pro Thr Asp Leu Phe Ser Asn Lys Glu Arg Gln 
                85                  90                  95      


His Gly Ala Val Leu Leu His Ile Leu Gly Ala Leu Tyr Met Phe Tyr 
            100                 105                 110         


Ala Leu Ala Ile Val Cys Asp Asp Phe Phe Val Pro Ser Leu Glu Lys 
        115                 120                 125             


Ile Cys Glu Arg Leu His Leu Ser Glu Asp Val Ala Gly Ala Thr Phe 
    130                 135                 140                 


Met Ala Ala Gly Ser Ser Thr Pro Glu Leu Phe Ala Ser Val Ile Gly 
145                 150                 155                 160 


Val Phe Ile Thr His Gly Asp Val Gly Val Gly Thr Ile Val Gly Ser 
                165                 170                 175     


Ala Val Phe Asn Ile Leu Cys Ile Ile Gly Val Cys Gly Leu Phe Ala 
            180                 185                 190         


Gly Gln Val Val Arg Leu Thr Trp Trp Ala Val Cys Arg Asp Ser Val 
        195                 200                 205             


Tyr Tyr Thr Ile Ser Val Ile Val Leu Ile Val Phe Ile Tyr Asp Glu 
    210                 215                 220                 


Gln Ile Val Trp Trp Glu Gly Leu Val Leu Ile Ile Leu Tyr Val Phe 
225                 230                 235                 240 


Tyr Ile Leu Ile Met Lys Tyr Asn Val Lys Met Gln Ala Phe Phe Thr 
                245                 250                 255     


Val Lys Gln Lys Ser Ile Ala Asn Gly Asn Pro Val Asn Ser Glu Leu 
            260                 265                 270         


Glu Ala Val Lys Glu Lys Pro Gln Tyr Gly Lys Asn Pro Val Val Met 
        275                 280                 285             


Val Asp Glu Ile Met Ser Ser Ser Pro Pro Lys Phe Thr Phe Pro Glu 
    290                 295                 300                 


Ala Gly Leu Arg Ile Met Ile Thr Asn Lys Phe Gly Pro Arg Thr Arg 
305                 310                 315                 320 


Leu Arg Met Ala Ser Arg Ile Ile Ile Asn Glu Arg Gln Arg Leu Ile 
                325                 330                 335     


Asn Ser Ala Asn Gly Val Ser Ser Lys Pro Leu Gln Asn Gly Arg His 
            340                 345                 350         


Glu Asn Ile Glu Asn Gly Asn Val Pro Val Glu Asn Pro Glu Asp Pro 
        355                 360                 365             


Gln Gln Asn Gln Glu Gln Gln Pro Pro Pro Gln Pro Pro Pro Pro Glu 
    370                 375                 380                 


Pro Glu Pro Val Glu Ala Asp Phe Leu Ser Pro Phe Ser Val Pro Glu 
385                 390                 395                 400 


Ala Arg Gly Asp Lys Val Lys Trp Val Phe Thr Trp Pro Leu Ile Phe 
                405                 410                 415     


Leu Leu Cys Val Thr Ile Pro Asn Cys Ser Lys Pro Arg Trp Glu Lys 
            420                 425                 430         


Phe Phe Met Val Thr Phe Ile Thr Ala Thr Leu Trp Ile Ala Val Phe 
        435                 440                 445             


Ser Tyr Ile Met Val Trp Leu Val Thr Ile Ile Gly Tyr Thr Leu Gly 
    450                 455                 460                 


Ile Pro Asp Val Ile Met Gly Ile Thr Phe Leu Ala Ala Gly Thr Ser 
465                 470                 475                 480 


Val Pro Asp Cys Met Ala Ser Leu Ile Val Ala Arg Gln Gly Leu Gly 
                485                 490                 495     


Asp Met Ala Val Ser Asn Thr Ile Gly Ser Asn Val Phe Asp Ile Leu 
            500                 505                 510         


Val Gly Leu Gly Val Pro Trp Gly Leu Gln Thr Met Val Val Asn Tyr 
        515                 520                 525             


Gly Ser Thr Val Lys Ile Asn Ser Arg Gly Leu Val Tyr Ser Val Val 
    530                 535                 540                 


Leu Leu Leu Gly Ser Val Ala Leu Thr Val Leu Gly Ile His Leu Asn 
545                 550                 555                 560 


Lys Trp Arg Leu Asp Arg Lys Leu Gly Val Tyr Val Leu Val Leu Tyr 
                565                 570                 575     


Ala Ile Phe Leu Cys Phe Ser Ile Met Ile Glu Phe Asn Val Phe Thr 
            580                 585                 590         


Phe Val Asn Leu Pro Met Cys Arg Glu Asp Asp 
        595                 600             


<210>  6211
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  6211

Met Ala Pro Val Asn Gly Thr Gln Thr Ala Lys Asn Cys Thr Asp Pro 
1               5                   10                  15      


Ala Ile His Glu Phe Pro Thr Asp Leu Phe Ser Asn Lys Glu Arg Gln 
            20                  25                  30          


His Gly Ala Val Leu Leu His Ile Leu Gly Ala Leu Tyr Met Phe Tyr 
        35                  40                  45              


Ala Leu Ala Ile Val Cys Asp Asp Phe Phe Val Pro Ser Leu Glu Lys 
    50                  55                  60                  


Ile Cys Glu Arg Leu His Leu Ser Glu Asp Val Ala Gly Ala Thr Phe 
65                  70                  75                  80  


Met Ala Ala Gly Ser Ser Thr Pro Glu Leu Phe Ala Ser Val Ile Gly 
                85                  90                  95      


Val Phe Ile Thr His Gly Asp Val Gly Val Gly Thr Ile Val Gly Ser 
            100                 105                 110         


Ala Val Phe Asn Ile Leu Cys Ile Ile Gly Val Cys Gly Leu Phe Ala 
        115                 120                 125             


Gly Gln Val Val Arg Leu Thr Trp Trp Ala Val Cys Arg Asp Ser Val 
    130                 135                 140                 


Tyr Tyr Thr Ile Ser Val Ile Val Leu Ile Val Phe Ile Tyr Asp Glu 
145                 150                 155                 160 


Gln Ile Val Trp Trp Glu Gly Leu Val Leu Ile Ile Leu Tyr Val Phe 
                165                 170                 175     


Tyr Ile Leu Ile Met Lys Tyr Asn Val Lys Met Gln Ala Phe Phe Thr 
            180                 185                 190         


Val Lys Gln Lys Ser Ile Ala Asn Gly Asn Pro Val Asn Ser Glu Leu 
        195                 200                 205             


Glu Ala Gly Asn Asp Phe Tyr Asp Gly Ser Tyr Asp Asp Pro Ser Val 
    210                 215                 220                 


Pro Leu Leu Gly Gln Val Lys Glu Lys Pro Gln Tyr Gly Lys Asn Pro 
225                 230                 235                 240 


Val Val Met Val Asp Glu Ile Met Ser Ser Ser Pro Pro Lys Phe Thr 
                245                 250                 255     


Phe Pro Glu Ala Gly Leu Arg Ile Met Ile Thr Asn Lys Phe Gly Pro 
            260                 265                 270         


Arg Thr Arg Leu Arg Met Ala Ser Arg Ile Ile Ile Asn Glu Arg Gln 
        275                 280                 285             


Arg Leu Ile Asn Ser Ala Asn Gly Val Ser Ser Lys Pro Leu Gln Asn 
    290                 295                 300                 


Gly Arg His Glu Asn Ile Glu Asn Gly Asn Val Pro Val Glu Asn Pro 
305                 310                 315                 320 


Glu Asp Pro Gln Gln Asn Gln Glu Gln Gln Pro Pro Pro Gln Pro Pro 
                325                 330                 335     


Pro Pro Glu Pro Glu Pro Val Glu Ala Asp Phe Leu Ser Pro Phe Ser 
            340                 345                 350         


Val Pro Glu Ala Arg Gly Asp Lys Val Lys Trp Val Phe Thr Trp Pro 
        355                 360                 365             


Leu Ile Phe Leu Leu Cys Val Thr Ile Pro Asn Cys Ser Lys Pro Arg 
    370                 375                 380                 


Trp Glu Lys Phe Phe Met Val Thr Phe Ile Thr Ala Thr Leu Trp Ile 
385                 390                 395                 400 


Ala Val Phe Ser Tyr Ile Met Val Trp Leu Val Thr Ile Ile Gly Tyr 
                405                 410                 415     


Thr Leu Gly Ile Pro Asp Val Ile Met Gly Ile Thr Phe Leu Ala Ala 
            420                 425                 430         


Gly Thr Ser Val Pro Asp Cys Met Ala Ser Leu Ile Val Ala Arg Gln 
        435                 440                 445             


Gly Leu Gly Asp Met Ala Val Ser Asn Thr Ile Gly Ser Asn Val Phe 
    450                 455                 460                 


Asp Ile Leu Val Gly Leu Gly Val Pro Trp Gly Leu Gln Thr Met Val 
465                 470                 475                 480 


Val Asn Tyr Gly Ser Thr Val Lys Ile Asn Ser Arg Gly Leu Val Tyr 
                485                 490                 495     


Ser Val Val Leu Leu Leu Gly Ser Val Ala Leu Thr Val Leu Gly Ile 
            500                 505                 510         


His Leu Asn Lys Trp Arg Leu Asp Arg Lys Leu Gly Val Tyr Val Leu 
        515                 520                 525             


Val Leu Tyr Ala Ile Phe Leu Cys Phe Ser Ile Met Ile Glu Phe Asn 
    530                 535                 540                 


Val Phe Thr Phe Val Asn Leu Pro Met Cys Arg Glu Asp Asp 
545                 550                 555             


<210>  6212
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  6212

Met Val Pro Arg Ser Thr Ser Leu Thr Leu Ile Val Phe Leu Phe His 
1               5                   10                  15      


Arg Leu Ser Lys Ala Pro Gly Lys Met Val Glu Asn Ser Pro Ser Pro 
            20                  25                  30          


Leu Pro Glu Arg Ala Ile Tyr Gly Phe Val Leu Phe Leu Ser Ser Gln 
        35                  40                  45              


Phe Gly Phe Ile Leu Tyr Leu Val Trp Ala Phe Ile Pro Glu Ser Trp 
    50                  55                  60                  


Leu Asn Ser Leu Gly Leu Thr Tyr Trp Pro Gln Lys Tyr Trp Ala Val 
65                  70                  75                  80  


Ala Leu Pro Val Tyr Leu Leu Ile Ala Ile Val Ile Gly Tyr Val Leu 
                85                  90                  95      


Leu Phe Gly Ile Asn Met Met Ser Thr Ser Pro Leu Asp Ser Ile His 
            100                 105                 110         


Thr Ile Thr Asp Asn Tyr Ala Lys Asn Gln Gln Gln Lys Lys Tyr Gln 
        115                 120                 125             


Glu Glu Ala Ile Pro Ala Leu Arg Asp Ile Ser Ile Ser Glu Val Asn 
    130                 135                 140                 


Gln Met Phe Phe Leu Ala Ala Lys Glu Leu Tyr Thr Lys Asn 
145                 150                 155             


<210>  6213
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  6213

Met Val Glu Asn Ser Pro Ser Pro Leu Pro Glu Arg Ala Ile Tyr Gly 
1               5                   10                  15      


Phe Val Leu Phe Leu Ser Ser Gln Phe Gly Phe Ile Leu Tyr Leu Val 
            20                  25                  30          


Trp Ala Phe Ile Pro Glu Ser Trp Leu Asn Ser Leu Gly Leu Thr Tyr 
        35                  40                  45              


Trp Pro Gln Lys Tyr Trp Ala Val Ala Leu Pro Val Tyr Leu Leu Ile 
    50                  55                  60                  


Ala Ile Val Ile Gly Tyr Val Leu Leu Phe Gly Ile Asn Met Met Ser 
65                  70                  75                  80  


Thr Ser Pro Leu Asp Ser Ile His Thr Ile Thr Asp Asn Tyr Ala Lys 
                85                  90                  95      


Asn Gln Gln Gln Lys Lys Tyr Gln Glu Glu Ala Ile Pro Ala Leu Arg 
            100                 105                 110         


Asp Ile Ser Ile Ser Glu Val Asn Gln Met Phe Phe Leu Ala Ala Lys 
        115                 120                 125             


Glu Leu Tyr Thr Lys Asn 
    130                 


<210>  6214
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  6214

Met Glu Ser Arg Met Trp Pro Ala Leu Leu Leu Ser His Leu Leu Pro 
1               5                   10                  15      


Leu Trp Pro Leu Leu Leu Leu Pro Leu Pro Pro Pro Ala Gln Gly Ser 
            20                  25                  30          


Ser Ser Ser Pro Arg Thr Pro Pro Ala Pro Ala Arg Pro Pro Cys Ala 
        35                  40                  45              


Arg Gly Gly Pro Ser Ala Pro Arg His Val Cys Val Trp Glu Arg Ala 
    50                  55                  60                  


Pro Pro Pro Ser Arg Ser Pro Arg Val Pro Arg Ser Arg Arg Gln Val 
65                  70                  75                  80  


Leu Pro Gly Thr Ala Pro Pro Ala Thr Pro Ser Gly Phe Glu Glu Gly 
                85                  90                  95      


Pro Pro Ser Ser Gln Tyr Pro Trp Ala Ile Val Trp Gly Pro Thr Val 
            100                 105                 110         


Ser Arg Glu Asp Gly Gly Asp Pro Asn Ser Ala Asn Pro Gly Phe Leu 
        115                 120                 125             


Asp Tyr Gly Phe Ala Ala Pro His Gly Leu Ala Thr Pro His Pro Asn 
    130                 135                 140                 


Ser Asp Ser Met Arg Gly Asp Gly Asp Gly Leu Ile Leu Gly Glu Ala 
145                 150                 155                 160 


Pro Ala Thr Leu Arg Pro Phe Leu Phe Gly Gly Arg Gly Glu Gly Val 
                165                 170                 175     


Asp Pro Gln Leu Tyr Val Thr Ile Thr Ile Ser Ile Ile Ile Val Leu 
            180                 185                 190         


Val Ala Thr Gly Ile Ile Phe Lys Phe Cys Trp Asp Arg Ser Gln Lys 
        195                 200                 205             


Arg Arg Arg Pro Ser Gly Gln Gln Gly Ala Leu Arg Gln Glu Glu Ser 
    210                 215                 220                 


Gln Gln Pro Leu Thr Asp Leu Ser Pro Ala Gly Val Thr Val Leu Gly 
225                 230                 235                 240 


Ala Phe Gly Asp Ser Pro Thr Pro Thr Pro Asp His Glu Glu Pro Arg 
                245                 250                 255     


Gly Gly Pro Arg Pro Gly Met Pro His Pro Lys Gly Ala Pro Ala Phe 
            260                 265                 270         


Gln Leu Asn Arg Ile Pro Leu Val Asn Leu 
        275                 280         


<210>  6215
<211>  476
<212>  PRT
<213>  Homo sapiens

<400>  6215

Met Ile Arg Pro Gln Leu Arg Thr Ala Gly Leu Gly Arg Cys Leu Leu 
1               5                   10                  15      


Pro Gly Leu Leu Leu Leu Leu Val Pro Val Leu Trp Ala Gly Ala Glu 
            20                  25                  30          


Lys Leu His Thr Gln Pro Ser Cys Pro Ala Val Cys Gln Pro Thr Arg 
        35                  40                  45              


Cys Pro Ala Leu Pro Thr Cys Ala Leu Gly Thr Thr Pro Val Phe Asp 
    50                  55                  60                  


Leu Cys Arg Cys Cys Arg Val Cys Pro Ala Ala Glu Arg Glu Val Cys 
65                  70                  75                  80  


Gly Gly Ala Gln Gly Gln Pro Cys Ala Pro Gly Leu Gln Cys Leu Gln 
                85                  90                  95      


Pro Leu Arg Pro Gly Phe Pro Ser Thr Cys Gly Cys Pro Thr Leu Gly 
            100                 105                 110         


Gly Ala Val Cys Gly Ser Asp Arg Arg Thr Tyr Pro Ser Met Cys Ala 
        115                 120                 125             


Leu Arg Ala Glu Asn Arg Ala Ala Arg Arg Leu Gly Lys Val Pro Ala 
    130                 135                 140                 


Val Pro Val Gln Trp Gly Asn Cys Gly Asp Thr Gly Thr Arg Ser Ala 
145                 150                 155                 160 


Gly Pro Leu Arg Arg Asn Tyr Asn Phe Ile Ala Ala Val Val Glu Lys 
                165                 170                 175     


Val Ala Pro Ser Val Val His Val Gln Leu Trp Gly Arg Leu Leu His 
            180                 185                 190         


Gly Ser Arg Leu Val Pro Val Tyr Ser Gly Ser Gly Phe Ile Val Ser 
        195                 200                 205             


Glu Asp Gly Leu Ile Ile Thr Asn Ala His Val Val Arg Asn Gln Gln 
    210                 215                 220                 


Trp Ile Glu Val Val Leu Gln Asn Gly Ala Arg Tyr Glu Ala Val Val 
225                 230                 235                 240 


Lys Asp Ile Asp Leu Lys Leu Asp Leu Ala Val Ile Lys Ile Glu Ser 
                245                 250                 255     


Asn Ala Glu Leu Pro Val Leu Met Leu Gly Arg Ser Ser Asp Leu Arg 
            260                 265                 270         


Ala Gly Glu Phe Val Val Ala Leu Gly Ser Pro Phe Ser Leu Gln Asn 
        275                 280                 285             


Thr Ala Thr Ala Gly Ile Val Ser Thr Lys Gln Arg Gly Gly Lys Glu 
    290                 295                 300                 


Leu Gly Met Lys Asp Ser Asp Met Asp Tyr Val Gln Ile Asp Ala Thr 
305                 310                 315                 320 


Ile Asn Tyr Gly Asn Ser Gly Gly Pro Leu Val Asn Leu Asp Gly Asp 
                325                 330                 335     


Val Ile Gly Val Asn Ser Leu Arg Val Thr Asp Gly Ile Ser Phe Ala 
            340                 345                 350         


Ile Pro Ser Asp Arg Val Arg Gln Phe Leu Ala Glu Tyr His Glu His 
        355                 360                 365             


Gln Met Lys Gly Lys Ala Phe Ser Asn Lys Lys Tyr Leu Gly Leu Gln 
    370                 375                 380                 


Met Leu Ser Leu Thr Val Pro Leu Ser Glu Glu Leu Lys Met His Tyr 
385                 390                 395                 400 


Pro Asp Phe Pro Asp Val Ser Ser Gly Val Tyr Val Cys Lys Val Val 
                405                 410                 415     


Glu Gly Thr Ala Ala Gln Ser Ser Gly Leu Arg Asp His Asp Val Ile 
            420                 425                 430         


Val Asn Ile Asn Gly Lys Pro Ile Thr Thr Thr Thr Asp Val Val Lys 
        435                 440                 445             


Ala Leu Asp Ser Asp Ser Leu Ser Met Ala Val Leu Arg Gly Lys Asp 
    450                 455                 460                 


Asn Leu Leu Leu Thr Val Ile Pro Glu Thr Ile Asn 
465                 470                 475     


<210>  6216
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  6216

Met Glu Pro Leu Val Thr Trp Val Val Pro Leu Leu Phe Leu Phe Leu 
1               5                   10                  15      


Leu Ser Arg Gln Gly Ala Ala Cys Arg Thr Ser Glu Cys Cys Phe Gln 
            20                  25                  30          


Asp Pro Pro Tyr Pro Asp Ala Asp Ser Gly Ser Ala Ser Gly Pro Arg 
        35                  40                  45              


Asp Leu Arg Cys Tyr Arg Ile Ser Ser Asp Arg Tyr Glu Cys Ser Trp 
    50                  55                  60                  


Gln Tyr Glu Gly Pro Thr Ala Gly Val Ser His Phe Leu Arg Cys Cys 
65                  70                  75                  80  


Leu Ser Ser Gly Arg Cys Cys Tyr Phe Ala Ala Gly Ser Ala Thr Arg 
                85                  90                  95      


Leu Gln Phe Ser Asp Gln Ala Gly Val Ser Val Leu Tyr Thr Val Thr 
            100                 105                 110         


Leu Trp Val Glu Ser Trp Ala Arg Asn Gln Thr Glu Lys Ser Pro Glu 
        115                 120                 125             


Val Thr Leu Gln Leu Tyr Asn Ser Val Lys Tyr Glu Pro Pro Leu Gly 
    130                 135                 140                 


Asp Ile Lys Val Ser Lys Leu Ala Gly Gln Leu Arg Met Glu Trp Glu 
145                 150                 155                 160 


Thr Pro Asp Asn Gln Val Gly Ala Glu Val Gln Phe Arg His Arg Thr 
                165                 170                 175     


Pro Ser Ser Pro Trp Lys Leu Gly Asp Cys Gly Pro Gln Asp Asp Asp 
            180                 185                 190         


Thr Glu Ser Cys Leu Cys Pro Leu Glu Met Asn Val Ala Gln Glu Phe 
        195                 200                 205             


Gln Leu Arg Arg Arg Gln Leu Gly Ser Gln Gly Ser Ser Trp Ser Lys 
    210                 215                 220                 


Trp Ser Ser Pro Val Cys Val Pro Pro Glu Asn Pro Pro Gln Pro Gln 
225                 230                 235                 240 


Val Arg Phe Ser Val Glu Gln Leu Gly Gln Asp Gly Arg Arg Arg Leu 
                245                 250                 255     


Thr Leu Lys Glu Gln Pro Thr Gln Leu Glu Leu Pro Glu Gly Cys Gln 
            260                 265                 270         


Gly Leu Ala Pro Gly Thr Glu Val Thr Tyr Arg Leu Gln Leu His Met 
        275                 280                 285             


Leu Ser Cys Pro Cys Lys Ala Lys Ala Thr Arg Thr Leu His Leu Gly 
    290                 295                 300                 


Lys Met Pro Tyr Leu Ser Gly Ala Ala Tyr Asn Val Ala Val Ile Ser 
305                 310                 315                 320 


Ser Asn Gln Phe Gly Pro Gly Leu Asn Gln Thr Trp His Ile Pro Ala 
                325                 330                 335     


Asp Thr His Thr Asp Gly Met Ile Ser Ala His Cys Asn Leu Arg Leu 
            340                 345                 350         


Pro Asp Ser Arg Asp Ser Pro Ala Ser Ala Ser Arg Val Ala Gly Ile 
        355                 360                 365             


Thr Gly Ile Cys His His Thr Arg Leu Ile Leu Tyr Phe 
    370                 375                 380     


<210>  6217
<211>  995
<212>  PRT
<213>  Homo sapiens

<400>  6217

Met Ala Thr Arg Gly Gly Ala Gly Val Ala Met Ala Val Trp Ser Leu 
1               5                   10                  15      


Leu Ser Ala Arg Ala Val Thr Ala Phe Leu Leu Leu Phe Leu Pro Arg 
            20                  25                  30          


Phe Leu Gln Ala Gln Thr Phe Ser Phe Pro Phe Gln Gln Pro Glu Lys 
        35                  40                  45              


Cys Asp Asn Asn Gln Tyr Phe Asp Ile Ser Ala Leu Ser Cys Val Pro 
    50                  55                  60                  


Cys Gly Ala Asn Gln Arg Gln Asp Ala Arg Gly Thr Ser Cys Val Cys 
65                  70                  75                  80  


Leu Pro Gly Phe Gln Met Ile Ser Asn Asn Gly Gly Pro Ala Ile Ile 
                85                  90                  95      


Cys Lys Lys Cys Pro Glu Asn Met Lys Gly Val Thr Glu Asp Gly Trp 
            100                 105                 110         


Asn Cys Ile Ser Cys Pro Ser Asp Leu Thr Ala Glu Gly Lys Cys His 
        115                 120                 125             


Cys Pro Ile Gly His Ile Leu Val Glu Arg Asp Ile Asn Gly Thr Leu 
    130                 135                 140                 


Leu Ser Gln Ala Thr Cys Glu Leu Cys Asp Gly Asn Glu Asn Ser Phe 
145                 150                 155                 160 


Met Val Val Asn Ala Leu Gly Asp Arg Cys Val Arg Cys Glu Pro Thr 
                165                 170                 175     


Phe Val Asn Thr Ser Arg Ser Cys Ala Cys Ser Glu Pro Asn Ile Leu 
            180                 185                 190         


Thr Gly Gly Leu Cys Phe Ser Ser Thr Gly Asn Phe Pro Leu Arg Arg 
        195                 200                 205             


Ile Ser Ala Ala Arg Tyr Gly Glu Val Gly Met Ser Leu Thr Ser Glu 
    210                 215                 220                 


Trp Phe Ala Lys Tyr Leu Gln Ser Ser Ala Ala Ala Cys Trp Val Tyr 
225                 230                 235                 240 


Ala Asn Leu Thr Ser Cys Gln Ala Leu Gly Asn Met Cys Val Met Asn 
                245                 250                 255     


Met Asn Ser Tyr Asp Phe Ala Thr Phe Asp Ala Cys Gly Leu Phe Gln 
            260                 265                 270         


Phe Ile Phe Glu Asn Thr Ala Gly Leu Ser Thr Val His Ser Ile Ser 
        275                 280                 285             


Phe Trp Arg Gln Asn Leu Pro Trp Leu Phe Tyr Gly Asp Gln Leu Gly 
    290                 295                 300                 


Leu Ala Pro Gln Val Leu Ser Ser Thr Ser Leu Pro Thr Asn Phe Ser 
305                 310                 315                 320 


Phe Lys Gly Glu Asn Gln Asn Thr Lys Leu Lys Phe Val Ala Ala Ser 
                325                 330                 335     


Tyr Asp Ile Arg Gly Asn Phe Leu Lys Trp Gln Thr Leu Glu Gly Gly 
            340                 345                 350         


Val Leu Gln Leu Cys Pro Asp Thr Glu Thr Arg Leu Asn Ala Ala Tyr 
        355                 360                 365             


Ser Phe Gly Thr Thr Tyr Gln Gln Asn Cys Glu Ile Pro Ile Ser Lys 
    370                 375                 380                 


Ile Leu Ile Asp Phe Pro Thr Pro Ile Phe Tyr Asp Val Tyr Leu Glu 
385                 390                 395                 400 


Tyr Thr Asp Glu Asn Gln His Gln Tyr Ile Leu Ala Val Pro Val Leu 
                405                 410                 415     


Asn Leu Asn Leu Gln His Asn Lys Ile Phe Val Asn Gln Asp Ser Asn 
            420                 425                 430         


Ser Gly Lys Trp Leu Leu Thr Arg Arg Ile Phe Leu Val Asp Ala Val 
        435                 440                 445             


Ser Gly Arg Glu Asn Asp Leu Gly Thr Gln Pro Arg Val Ile Arg Val 
    450                 455                 460                 


Ala Thr Gln Ile Ser Leu Ser Val His Leu Val Pro Asn Thr Ile Asn 
465                 470                 475                 480 


Gly Asn Ile Tyr Pro Pro Leu Ile Thr Ile Ala Tyr Ser Asp Ile Asp 
                485                 490                 495     


Ile Lys Asp Ala Asn Ser Gln Ser Val Lys Val Ser Phe Ser Val Thr 
            500                 505                 510         


Tyr Glu Met Asp His Gly Glu Ala His Val Gln Thr Asp Ile Ala Leu 
        515                 520                 525             


Gly Val Leu Gly Gly Leu Ala Val Leu Ala Ser Leu Leu Lys Thr Ala 
    530                 535                 540                 


Gly Trp Lys Arg Arg Ile Gly Ser Pro Met Ile Asp Leu Gln Thr Val 
545                 550                 555                 560 


Val Lys Phe Leu Val Tyr Tyr Ala Gly Asp Leu Ala Asn Val Phe Phe 
                565                 570                 575     


Ile Ile Thr Val Gly Thr Gly Leu Tyr Trp Leu Ile Phe Phe Lys Ala 
            580                 585                 590         


Gln Lys Ser Val Ser Val Leu Leu Pro Met Pro Ile Gln Glu Glu Arg 
        595                 600                 605             


Phe Val Thr Tyr Val Gly Cys Ala Phe Ala Leu Lys Ala Leu Gln Phe 
    610                 615                 620                 


Leu His Lys Leu Ile Ser Gln Ile Thr Ile Asp Val Phe Phe Ile Asp 
625                 630                 635                 640 


Trp Glu Arg Pro Lys Gly Lys Val Leu Lys Ala Val Glu Gly Glu Gly 
                645                 650                 655     


Gly Val Arg Ser Ala Thr Val Pro Val Ser Ile Trp Arg Thr Tyr Phe 
            660                 665                 670         


Val Ala Asn Glu Trp Asn Glu Ile Gln Thr Val Arg Lys Ile Asn Ser 
        675                 680                 685             


Leu Phe Gln Val Leu Thr Val Leu Phe Phe Leu Glu Val Val Gly Phe 
    690                 695                 700                 


Lys Asn Leu Ala Leu Met Asp Ser Ser Ser Ser Leu Ser Arg Asn Pro 
705                 710                 715                 720 


Pro Ser Tyr Ile Ala Pro Tyr Ser Cys Ile Leu Arg Tyr Ala Val Ser 
                725                 730                 735     


Ala Ala Leu Trp Leu Ala Ile Gly Ile Ile Gln Val Val Phe Phe Ala 
            740                 745                 750         


Val Phe Tyr Glu Arg Phe Ile Glu Asp Lys Ile Arg Gln Phe Val Asp 
        755                 760                 765             


Leu Cys Ser Met Ser Asn Ile Ser Val Phe Leu Leu Ser His Lys Cys 
    770                 775                 780                 


Phe Gly Tyr Tyr Ile His Gly Arg Ser Val His Gly His Ala Asp Thr 
785                 790                 795                 800 


Asn Met Glu Glu Met Asn Met Asn Leu Lys Arg Glu Ala Glu Asn Leu 
                805                 810                 815     


Cys Ser Gln Arg Gly Leu Val Pro Asn Thr Asp Gly Gln Thr Phe Glu 
            820                 825                 830         


Ile Ala Ile Ser Asn Gln Met Arg Gln His Tyr Asp Arg Ile His Glu 
        835                 840                 845             


Thr Leu Ile Arg Lys Asn Gly Pro Ala Arg Leu Leu Ser Ser Ser Ala 
    850                 855                 860                 


Ser Thr Phe Glu Gln Ser Ile Lys Ala Tyr His Met Met Asn Lys Phe 
865                 870                 875                 880 


Leu Gly Ser Phe Ile Asp His Val His Lys Glu Met Asp Tyr Phe Ile 
                885                 890                 895     


Lys Asp Lys Leu Leu Leu Glu Arg Ile Leu Gly Met Glu Phe Met Glu 
            900                 905                 910         


Pro Met Glu Lys Ser Ile Phe Tyr Asn Asp Glu Gly Tyr Ser Phe Ser 
        915                 920                 925             


Ser Val Leu Tyr Tyr Gly Asn Glu Ala Thr Leu Leu Ile Phe Asp Leu 
    930                 935                 940                 


Leu Phe Phe Cys Val Val Asp Leu Ala Cys Gln Asn Phe Ile Leu Ala 
945                 950                 955                 960 


Ser Phe Leu Thr Tyr Leu Gln Gln Glu Ile Phe Arg Tyr Ile Arg Asn 
                965                 970                 975     


Thr Val Gly Gln Lys Asn Leu Ala Ser Lys Thr Leu Val Asp Gln Arg 
            980                 985                 990         


Phe Leu Ile 
        995 


<210>  6218
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  6218

Met Arg Ile Phe Arg Pro Trp Arg Leu Arg Cys Pro Ala Leu His Leu 
1               5                   10                  15      


Pro Ser Leu Ser Val Phe Ser Leu Arg Trp Lys Leu Pro Ser Leu Thr 
            20                  25                  30          


Thr Asp Glu Thr Met Cys Lys Ser Val Thr Thr Asp Glu Trp Lys Lys 
        35                  40                  45              


Val Phe Tyr Glu Lys Met Glu Glu Ala Lys Pro Ala Asp Ser Trp Asp 
    50                  55                  60                  


Leu Ile Ile Asp Pro Asn Leu Lys His Asn Val Leu Ser Pro Gly Trp 
65                  70                  75                  80  


Lys Gln Tyr Leu Glu Leu His Ala Ser Gly Arg Phe His Cys Ser Trp 
                85                  90                  95      


Cys Trp His Thr Trp Gln Ser Pro Tyr Val Val Ile Leu Phe His Met 
            100                 105                 110         


Phe Leu Asp Arg Ala Gln Arg Ala Gly Ser Val Arg Met Arg Val Phe 
        115                 120                 125             


Lys Gln Leu Cys Tyr Glu Cys Gly Thr Ala Arg Leu Asp Glu Ser Ser 
    130                 135                 140                 


Met Leu Glu Glu Asn Ile Glu Gly Leu Val Asp Asn Leu Ile Thr Ser 
145                 150                 155                 160 


Leu Arg Glu Gln Cys Tyr Gly Glu Arg Gly Gly Gln Tyr Arg Ile His 
                165                 170                 175     


Val Ala Ser Arg Gln Asp Asn Arg Arg His Arg Gly Glu Phe Cys Glu 
            180                 185                 190         


Ala Cys Gln Glu Gly Ile Val His Trp Lys Pro Ser Glu Lys Leu Leu 
        195                 200                 205             


Glu Glu Glu Ala Thr Thr Tyr Thr Phe Ser Arg Ala Pro Ser Pro Thr 
    210                 215                 220                 


Lys Ser Gln Asp Gln Thr Gly Ser Gly Trp Asn Phe Cys Ser Ile Pro 
225                 230                 235                 240 


Trp Cys Leu Phe Trp Ala Thr Val Leu Leu Leu Ile Ile Tyr Leu Gln 
                245                 250                 255     


Phe Ser Phe Arg Ser Ser Val 
            260             


<210>  6219
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  6219

Met Asp Ala Phe Gln Gly Ile Leu Lys Phe Phe Leu Asn Gln Lys Thr 
1               5                   10                  15      


Val Ile Gly Tyr Ser Phe Met Ala Leu Leu Thr Val Gly Ser Glu Arg 
            20                  25                  30          


Leu Phe Ser Val Val Ala Phe Lys Cys Pro Cys Ser Thr Glu Asn Met 
        35                  40                  45              


Thr Tyr Gly Leu Val Phe Leu Phe Ala Pro Ala Trp Val Leu Leu Ile 
    50                  55                  60                  


Leu Gly Phe Phe Leu Asn Asn Arg Ser Trp Arg Leu Phe Thr Gly Cys 
65                  70                  75                  80  


Cys Val Asn Pro Arg Lys Ile Phe Pro Arg Gly His Ser Cys Arg Phe 
                85                  90                  95      


Phe Tyr Val Leu Gly Gln Ile Thr Leu Ser Ser Leu Val Ala Pro Val 
            100                 105                 110         


Met Trp Leu Ser Val Ala Leu Leu Asn Gly Thr Phe Tyr Glu Cys Ala 
        115                 120                 125             


Met Ser Gly Thr Arg Ser Ser Gly Leu Leu Glu Leu Ile Cys Lys Gly 
    130                 135                 140                 


Lys Pro Lys Glu Cys Trp Glu Glu Leu His Lys Val Ser Cys Gly Lys 
145                 150                 155                 160 


Thr Ser Met Leu Pro Thr Val Asn Glu Glu Leu Lys Leu Ser Leu Gln 
                165                 170                 175     


Ala Gln Ser Gln Ile Leu Gly Trp Cys Leu Ile Cys Ser Ala Ser Phe 
            180                 185                 190         


Phe Ser Leu Leu Thr Thr Cys Tyr Ala Arg Cys Arg Ser Lys Val Ser 
        195                 200                 205             


Tyr Leu Gln Leu Ser Phe Trp Lys Thr Tyr Ala Gln Lys Glu Lys Glu 
    210                 215                 220                 


Gln Leu Glu Asn Thr Phe Leu Asp Tyr Ala Asn Lys Leu Ser Glu Arg 
225                 230                 235                 240 


Asn Leu Lys Cys Phe Phe Glu Asn Lys Arg Pro Asp Pro Phe Pro Met 
                245                 250                 255     


Pro Thr Phe Ala Ala Trp Glu Ala Ala Ser Glu Leu His Ser Phe His 
            260                 265                 270         


Gln Ser Gln Gln His Tyr Ser Thr Leu His Arg Val Val Asp Asn Gly 
        275                 280                 285             


Leu Gln Leu Ser Pro Glu Asp Asp Glu Thr Thr Met Val Leu Val Gly 
    290                 295                 300                 


Thr Ala His Asn Met 
305                 


<210>  6220
<211>  992
<212>  PRT
<213>  Homo sapiens

<400>  6220

Met Ala Arg Gly Gly Ala Ala Cys Lys Ser Asp Ala Arg Leu Leu Leu 
1               5                   10                  15      


Gly Arg Asp Ala Leu Arg Pro Ala Pro Ala Leu Leu Ala Pro Ala Val 
            20                  25                  30          


Leu Leu Gly Ala Ala Leu Gly Leu Gly Leu Gly Leu Trp Leu Gly Cys 
        35                  40                  45              


Arg Ala Gly Arg Gln Arg Thr Arg His Gln Lys Asp Asp Thr Gln Asn 
    50                  55                  60                  


Leu Leu Lys Asn Leu Glu Ser Asn Ala Gln Thr Pro Ser Glu Thr Gly 
65                  70                  75                  80  


Ser Pro Ser Arg Arg Arg Lys Arg Glu Val Gln Met Ser Lys Asp Lys 
                85                  90                  95      


Glu Ala Val Asp Glu Cys Glu Pro Pro Ser Asn Ser Asn Ile Thr Ala 
            100                 105                 110         


Phe Ala Leu Lys Ala Lys Val Ile Tyr Pro Ile Asn Gln Lys Phe Arg 
        115                 120                 125             


Pro Leu Ala Asp Gly Ser Ser Asn Pro Ser Leu His Glu Asn Leu Lys 
    130                 135                 140                 


Gln Ala Val Leu Pro His Gln Pro Val Glu Ala Ser Pro Ser Ser Ser 
145                 150                 155                 160 


Leu Gly Ser Leu Ser Gln Gly Glu Lys Asp Asp Cys Ser Ser Ser Ser 
                165                 170                 175     


Ser Val His Ser Ala Thr Ser Asp Asp Arg Phe Leu Ser Arg Thr Phe 
            180                 185                 190         


Leu Arg Val Asn Ala Phe Pro Glu Val Leu Ala Cys Glu Ser Val Asp 
        195                 200                 205             


Val Asp Leu Cys Ile Tyr Ser Leu His Leu Lys Asp Leu Leu His Leu 
    210                 215                 220                 


Asp Thr Ala Leu Arg Gln Glu Lys His Met Met Phe Ile Gln Ile Phe 
225                 230                 235                 240 


Lys Met Cys Leu Leu Asp Leu Leu Pro Lys Lys Lys Ser Asp Asp Glu 
                245                 250                 255     


Leu Tyr Gln Lys Ile Leu Ser Lys Gln Glu Lys Asp Leu Glu Glu Leu 
            260                 265                 270         


Glu Lys Gly Leu Gln Val Lys Leu Ser Asn Thr Glu Met Ser Gly Ala 
        275                 280                 285             


Gly Asp Ser Glu Tyr Ile Thr Leu Ala Asp Val Glu Lys Lys Glu Arg 
    290                 295                 300                 


Glu Tyr Ser Glu Gln Leu Ile Asp Asn Met Glu Ala Phe Trp Lys Gln 
305                 310                 315                 320 


Met Ala Asn Ile Gln His Phe Leu Val Asp Gln Phe Lys Cys Ser Ser 
                325                 330                 335     


Ser Lys Ala Arg Gln Leu Met Met Thr Leu Thr Glu Arg Met Ile Ala 
            340                 345                 350         


Ala Glu Gly Leu Leu Cys Asp Ser Gln Glu Leu Gln Ala Leu Asp Ala 
        355                 360                 365             


Leu Glu Arg Thr Met Gly Arg Ala His Met Ala Lys Val Ile Glu Phe 
    370                 375                 380                 


Leu Lys Leu Gln Val Gln Glu Glu Thr Arg Cys Arg Leu Ala Ala Ile 
385                 390                 395                 400 


Ser His Gly Leu Glu Leu Leu Ala Gly Glu Gly Lys Leu Ser Gly Arg 
                405                 410                 415     


Gln Lys Glu Glu Leu Leu Thr Gln Gln His Lys Ala Phe Trp Gln Glu 
            420                 425                 430         


Ala Glu Arg Phe Ser Arg Glu Phe Val Gln Arg Gly Lys Asp Leu Val 
        435                 440                 445             


Thr Ala Ser Leu Ala His Gln Val Glu Gly Thr Ala Lys Leu Thr Leu 
    450                 455                 460                 


Ala Gln Glu Glu Glu Gln Arg Ser Phe Leu Ala Glu Ala Gln Pro Thr 
465                 470                 475                 480 


Ala Asp Pro Glu Lys Phe Leu Glu Ala Phe His Glu Val Leu Glu Arg 
                485                 490                 495     


Gln Arg Leu Met Gln Cys Asp Leu Glu Glu Glu Glu Asn Val Arg Ala 
            500                 505                 510         


Thr Glu Ala Val Val Ala Leu Cys Gln Glu Leu Tyr Phe Ser Thr Val 
        515                 520                 525             


Asp Thr Phe Gln Lys Phe Val Asp Ala Leu Phe Leu Gln Thr Leu Pro 
    530                 535                 540                 


Gly Met Thr Gly Leu Pro Pro Glu Glu Cys Asp Tyr Leu Arg Gln Glu 
545                 550                 555                 560 


Val Gln Glu Asn Ala Ala Trp Gln Leu Gly Lys Ser Asn Arg Phe Arg 
                565                 570                 575     


Arg Gln Gln Trp Lys Leu Phe Gln Glu Leu Leu Glu Gln Asp Gln Gln 
            580                 585                 590         


Val Trp Met Glu Glu Cys Ala Leu Ser Ser Val Leu Gln Thr His Leu 
        595                 600                 605             


Arg Glu Asp His Glu Gly Thr Ile Arg Gly Val Leu Gly Arg Leu Gly 
    610                 615                 620                 


Gly Leu Thr Glu Glu Ser Thr Arg Cys Val Leu Gln Gly His Asp Leu 
625                 630                 635                 640 


Leu Leu Arg Ser Ala Leu Arg Arg Leu Ala Leu Arg Gly Asn Ala Leu 
                645                 650                 655     


Ala Thr Leu Thr Gln Met Arg Leu Ser Gly Lys Lys His Leu Leu Gln 
            660                 665                 670         


Glu Leu Arg Glu Gln Arg Ala Leu Glu Gln Gly Ser Ser Gln Cys Leu 
        675                 680                 685             


Asp Glu His Gln Trp Gln Leu Leu Arg Ala Leu Glu Ala Arg Val Leu 
    690                 695                 700                 


Glu Glu Ala Ser Arg Leu Glu Glu Glu Ala Gln Gln Thr Arg Leu Gln 
705                 710                 715                 720 


Leu Gln Gln Arg Leu Leu Ala Glu Ala Gln Glu Val Gly Gln Leu Leu 
                725                 730                 735     


Gln Gln His Met Glu Cys Ala Ile Gly Gln Ala Leu Leu Val His Ala 
            740                 745                 750         


Arg Asn Ala Ala Thr Lys Ser Arg Ala Lys Asp Arg Asp Asp Phe Lys 
        755                 760                 765             


Arg Thr Leu Met Glu Ala Ala Val Glu Ser Val Tyr Val Thr Ser Ala 
    770                 775                 780                 


Gly Val Ser Arg Leu Val Gln Ala Tyr Tyr Gln Gln Ile Gly Arg Ile 
785                 790                 795                 800 


Met Glu Asp His Glu Glu Arg Lys Leu Gln His Leu Lys Thr Leu Gln 
                805                 810                 815     


Gly Glu Arg Met Glu Asn Tyr Lys Leu Arg Lys Lys Gln Glu Leu Ser 
            820                 825                 830         


Asn Pro Ser Ser Gly Ser Arg Thr Ala Gly Gly Ala His Glu Thr Ser 
        835                 840                 845             


Gln Ala Val His Gln Arg Met Leu Ser Gln Gln Lys Arg Phe Leu Ala 
    850                 855                 860                 


Gln Phe Pro Val His Gln Gln Met Arg Leu His Ala Gln Gln Gln Gln 
865                 870                 875                 880 


Ala Gly Val Met Asp Leu Leu Glu Ala Gln Leu Glu Thr Gln Leu Gln 
                885                 890                 895     


Glu Ala Glu Gln Asn Phe Ile Ser Glu Leu Ala Ala Leu Ala Arg Val 
            900                 905                 910         


Pro Leu Ala Glu Ser Lys Leu Leu Pro Ala Lys Arg Gly Leu Leu Glu 
        915                 920                 925             


Lys Pro Leu Arg Thr Lys Arg Lys Lys Pro Leu Pro Gln Glu Arg Gly 
    930                 935                 940                 


Asp Leu Gly Val Pro Asn Asn Glu Asp Leu Ala Ser Gly Asp Gln Thr 
945                 950                 955                 960 


Ser Gly Ser Leu Ser Ser Lys Arg Leu Ser Gln Gln Glu Ser Glu Ala 
                965                 970                 975     


Gly Asp Ser Gly Asn Ser Lys Lys Met Leu Lys Arg Arg Ser Asn Leu 
            980                 985                 990         


<210>  6221
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  6221

Met Pro Pro Gly Gly Gly Gly Pro Met Lys Asp Cys Glu Tyr Ser Gln 
1               5                   10                  15      


Ile Ser Thr His Ser Ser Ser Pro Met Glu Ser Pro His Lys Lys Lys 
            20                  25                  30          


Lys Ile Ala Ala Arg Arg Lys Trp Glu Val Phe Pro Gly Arg Asn Lys 
        35                  40                  45              


Phe Phe Cys Asn Gly Arg Ile Met Met Ala Arg Gln Thr Gly Val Phe 
    50                  55                  60                  


Tyr Leu Thr Leu Val Leu Ile Leu Val Thr Ser Gly Leu Phe Phe Ala 
65                  70                  75                  80  


Phe Asp Cys Pro Tyr Leu Ala Val Lys Ile Thr Pro Ala Ile Pro Ala 
                85                  90                  95      


Val Ala Gly Ile Leu Phe Phe Phe Val Met Gly Thr Leu Leu Arg Thr 
            100                 105                 110         


Ser Phe Ser Asp Pro Gly Val Leu Pro Arg Ala Thr Pro Asp Glu Ala 
        115                 120                 125             


Ala Asp Leu Glu Arg Gln Ile Asp Ile Ala Asn Gly Thr Ser Ser Gly 
    130                 135                 140                 


Gly Tyr Arg Pro Pro Pro Arg Thr Lys Glu Val Ile Ile Asn Gly Gln 
145                 150                 155                 160 


Thr Val Lys Leu Lys Tyr Cys Phe Thr Cys Lys Ile Phe Arg Pro Pro 
                165                 170                 175     


Arg Ala Ser His Cys Ser Leu Cys Asp Asn Cys Val Glu Arg Phe Asp 
            180                 185                 190         


His His Cys Pro Trp Val Gly Asn Cys Val Gly Lys Arg Asn Tyr Arg 
        195                 200                 205             


Phe Phe Tyr Met Phe Ile Leu Ser Leu Ser Phe Leu Thr Val Phe Ile 
    210                 215                 220                 


Phe Ala Phe Val Ile Thr His Val Ile Leu Arg Ser Gln Gln Thr Gly 
225                 230                 235                 240 


Phe Leu Asn Ala Leu Lys Asp Ser Pro Ala Ser Val Leu Glu Ala Val 
                245                 250                 255     


Val Cys Phe Phe Ser Val Trp Ser Ile Val Gly Leu Ser Gly Phe His 
            260                 265                 270         


Thr Tyr Leu Ile Ser Ser Asn Gln Thr Thr Asn Glu Asp Ile Lys Gly 
        275                 280                 285             


Ser Trp Ser Asn Lys Arg Gly Lys Glu Asn Tyr Asn Pro Tyr Ser Tyr 
    290                 295                 300                 


Gly Asn Ile Phe Thr Asn Cys Cys Val Ala Leu Cys Gly Pro Ile Ser 
305                 310                 315                 320 


Pro Ser Leu Ile Asp Arg Arg Gly Tyr Ile Gln Pro Asp Thr Pro Gln 
                325                 330                 335     


Pro Ala Ala Pro Ser Asn Gly Ile Thr Met Tyr Gly Ala Thr Gln Ser 
            340                 345                 350         


Gln Ser Asp Met Ala Ala Ala Thr Pro Leu Leu Gln Ser Glu Pro Ser 
        355                 360                 365             


Leu Thr Ser Asp Glu Leu His Leu Pro Gly Lys Pro Gly Leu Gly Thr 
    370                 375                 380                 


Pro Cys Ala Ser Leu Thr Leu Gly Pro Pro Thr Pro Pro Ala Ser Met 
385                 390                 395                 400 


Pro Asn Leu Ala Glu Ala Thr Leu Ala Asp Val Met Pro Arg Lys Asp 
                405                 410                 415     


Glu His Met Gly His Gln Phe Leu Thr Pro Asp Glu Ala Pro Ser Pro 
            420                 425                 430         


Pro Arg Leu Leu Ala Ala Gly Ser Pro Leu Ala His Ser Arg Thr Met 
        435                 440                 445             


His Val Leu Gly Leu Ala Ser Gln Asp Ser Leu His Glu Asp Ser Val 
    450                 455                 460                 


Arg Gly Leu Val Lys Leu Ser Ser Val 
465                 470             


<210>  6222
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  6222

Met Tyr Ala Gln Pro Val Thr Asn Thr Lys Glu Val Lys Trp Gln Lys 
1               5                   10                  15      


Val Leu Tyr Glu Arg Gln Pro Phe Pro Asp Asn Tyr Val Asp Arg Arg 
            20                  25                  30          


Phe Leu Glu Glu Leu Arg Lys Asn Ile His Ala Arg Lys Tyr Gln Tyr 
        35                  40                  45              


Trp Ala Val Val Phe Glu Ser Ser Val Val Ile Gln Gln Leu Cys Ser 
    50                  55                  60                  


Val Cys Val Phe Val Val Ile Trp Trp Tyr Met Asp Glu Gly Leu Leu 
65                  70                  75                  80  


Ala Pro His Trp Leu Leu Gly Thr Gly Leu Ala Ser Ser Leu Ile Gly 
                85                  90                  95      


Tyr Val Leu Phe Asp Leu Ile Asp Gly Gly Glu Gly Arg Lys Lys Ser 
            100                 105                 110         


Gly Gln Thr Arg Trp Ala Asp Leu Lys Ser Ala Leu Val Phe Ile Thr 
        115                 120                 125             


Phe Thr Tyr Gly Phe Ser Pro Val Leu Lys Thr Leu Thr Glu Ser Val 
    130                 135                 140                 


Ser Thr Asp Thr Ile Tyr Ala Met Ser Val Phe Met Leu Leu Gly His 
145                 150                 155                 160 


Leu Ile Phe Phe Asp Tyr Gly Ala Asn Ala Ala Ile Val Ser Ser Thr 
                165                 170                 175     


Leu Ser Leu Asn Met Ala Ile Phe Ala Ser Val Cys Leu Ala Ser Arg 
            180                 185                 190         


Leu Pro Arg Ser Leu His Ala Phe Ile Met Val Thr Phe Ala Ile Gln 
        195                 200                 205             


Ile Phe Ala Leu Trp Pro Met Leu Gln Lys Lys Leu Lys Ala Cys Thr 
    210                 215                 220                 


Pro Arg Ser Tyr Val Gly Val Thr Leu Leu Phe Ala Phe Ser Ala Val 
225                 230                 235                 240 


Gly Gly Leu Leu Ser Ile Ser Ala Val Gly Ala Val Leu Phe Ala Leu 
                245                 250                 255     


Leu Leu Met Ser Ile Ser Cys Leu Cys Pro Phe Tyr Leu Ile Arg Leu 
            260                 265                 270         


Gln Leu Phe Lys Glu Asn Ile His Gly Pro Trp Asp Glu Ala Glu Ile 
        275                 280                 285             


Lys Glu Asp Leu Ser Arg Phe Leu Ser 
    290                 295         


<210>  6223
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  6223

Met Gly Lys Ile Glu Asn Asn Glu Arg Val Ile Leu Asn Val Gly Gly 
1               5                   10                  15      


Thr Arg His Glu Thr Tyr Arg Ser Thr Leu Lys Thr Leu Pro Gly Thr 
            20                  25                  30          


Arg Leu Ala Leu Leu Ala Ser Ser Glu Pro Pro Gly Asp Cys Leu Thr 
        35                  40                  45              


Thr Ala Gly Asp Lys Leu Gln Pro Ser Pro Pro Pro Leu Ser Pro Pro 
    50                  55                  60                  


Pro Arg Ala Pro Pro Leu Ser Pro Gly Pro Gly Gly Cys Phe Glu Gly 
65                  70                  75                  80  


Gly Ala Gly Asn Cys Ser Ser Arg Gly Gly Arg Ala Ser Asp His Pro 
                85                  90                  95      


Gly Gly Gly Arg Glu Phe Phe Phe Asp Arg His Pro Gly Val Phe Ala 
            100                 105                 110         


Tyr Val Leu Asn Tyr Tyr Arg Thr Gly Lys Leu His Cys Pro Ala Asp 
        115                 120                 125             


Val Cys Gly Pro Leu Phe Glu Glu Glu Leu Ala Phe Trp Gly Ile Asp 
    130                 135                 140                 


Glu Thr Asp Val Glu Pro Cys Cys Trp Met Thr Tyr Arg Gln His Arg 
145                 150                 155                 160 


Asp Ala Glu Glu Ala Leu Asp Ile Phe Glu Thr Pro Asp Leu Ile Gly 
                165                 170                 175     


Gly Asp Pro Gly Asp Asp Glu Asp Leu Ala Ala Lys Arg Leu Gly Ile 
            180                 185                 190         


Glu Asp Ala Ala Gly Leu Gly Gly Pro Asp Gly Lys Ser Gly Arg Trp 
        195                 200                 205             


Arg Arg Leu Gln Pro Arg Met Trp Ala Leu Phe Glu Asp Pro Tyr Ser 
    210                 215                 220                 


Ser Arg Ala Ala Arg Phe Ile Ala Phe Ala Ser Leu Phe Phe Ile Leu 
225                 230                 235                 240 


Val Ser Ile Thr Thr Phe Cys Leu Glu Thr His Glu Ala Phe Asn Ile 
                245                 250                 255     


Val Lys Asn Lys Thr Glu Pro Val Ile Asn Gly Thr Ser Val Val Leu 
            260                 265                 270         


Gln Tyr Glu Ile Glu Thr Asp Pro Ala Leu Thr Tyr Val Glu Gly Val 
        275                 280                 285             


Cys Val Val Trp Phe Thr Phe Glu Phe Leu Val Arg Ile Val Phe Ser 
    290                 295                 300                 


Pro Asn Lys Leu Glu Phe Ile Lys Asn Leu Leu Asn Ile Ile Asp Phe 
305                 310                 315                 320 


Val Ala Ile Leu Pro Phe Tyr Leu Glu Val Gly Leu Ser Gly Leu Ser 
                325                 330                 335     


Ser Lys Ala Ala Lys Asp Val Leu Gly Phe Leu Arg Val Val Arg Phe 
            340                 345                 350         


Val Arg Ile Leu Arg Ile Phe Lys Leu Thr Arg His Phe Val Gly Leu 
        355                 360                 365             


Arg Val Leu Gly His Thr Leu Arg Ala Ser Thr Asn Glu Phe Leu Leu 
    370                 375                 380                 


Leu Ile Ile Phe Leu Ala Leu Gly Val Leu Ile Phe Ala Thr Met Ile 
385                 390                 395                 400 


Tyr Tyr Ala Glu Arg Val Gly Ala Gln Pro Asn Asp Pro Ser Ala Ser 
                405                 410                 415     


Glu His Thr Gln Phe Lys Asn Ile Pro Ile Gly Phe Trp Trp Ala Val 
            420                 425                 430         


Val Thr Met Thr Thr Leu Gly Tyr Gly Asp Met Tyr Pro Gln Thr Trp 
        435                 440                 445             


Ser Gly Met Leu Val Gly Ala Leu Cys Ala Leu Ala Gly Val Leu Thr 
    450                 455                 460                 


Ile Ala Met Pro Val Pro Val Ile Val Asn Asn Phe Gly Met Tyr Tyr 
465                 470                 475                 480 


Ser Leu Ala Met Ala Lys Gln Lys Leu Pro Arg Lys Arg Lys Lys His 
                485                 490                 495     


Ile Pro Pro Ala Pro Gln Ala Ser Ser Pro Thr Phe Cys Lys Thr Glu 
            500                 505                 510         


Leu Asn Met Ala Cys Asn Ser Thr Gln Ser Asp Thr Cys Leu Gly Lys 
        515                 520                 525             


Asp Asn Arg Leu Leu Glu His Asn Arg Ser Asp Asn Cys Lys Glu Val 
    530                 535                 540                 


Val Ile Thr Gly Tyr Thr Gln Ala Glu Ala Arg Ser Leu Thr 
545                 550                 555             


<210>  6224
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  6224

Met His Pro Gly Ser Pro Ser Ala Trp Pro Pro Arg Ala Arg Ala Ala 
1               5                   10                  15      


Leu Arg Leu Trp Leu Gly Cys Val Cys Phe Ala Leu Val Gln Ala Asp 
            20                  25                  30          


Ser Pro Ser Ala Pro Val Asn Val Thr Val Arg His Leu Lys Ala Asn 
        35                  40                  45              


Ser Ala Val Val Ser Trp Asp Val Leu Glu Asp Glu Val Val Ile Gly 
    50                  55                  60                  


Phe Ala Ile Ser Gln Gln Lys Lys Asp Val Arg Met Leu Arg Phe Ile 
65                  70                  75                  80  


Gln Glu Val Asn Thr Thr Thr Arg Ser Cys Ala Leu Trp Asp Leu Glu 
                85                  90                  95      


Glu Asp Thr Glu Tyr Ile Val His Val Gln Ala Ile Ser Ile Gln Gly 
            100                 105                 110         


Gln Ser Pro Ala Ser Glu Pro Val Leu Phe Lys Thr Pro Arg Glu Ala 
        115                 120                 125             


Glu Lys Met Ala Ser Lys Asn Lys Asp Glu Val Thr Met Lys Glu Met 
    130                 135                 140                 


Gly Arg Asn Gln Gln Leu Arg Thr Gly Glu Val Leu Ile Ile Val Val 
145                 150                 155                 160 


Val Leu Phe Met Trp Ala Gly Val Ile Ala Leu Phe Cys Arg Gln Tyr 
                165                 170                 175     


Asp Ile Ile Lys Asp Asn Glu Pro Asn Asn Asn Lys Glu Lys Thr Lys 
            180                 185                 190         


Ser Ala Ser Glu Thr Ser Thr Pro Glu His Gln Gly Gly Gly Leu Leu 
        195                 200                 205             


Arg Ser Lys Ile 
    210         


<210>  6225
<211>  626
<212>  PRT
<213>  Homo sapiens

<400>  6225

Met Ile Ser Ser Val Cys Val Ser Ser Tyr Arg Gly Arg Lys Ser Gly 
1               5                   10                  15      


Asn Lys Pro Pro Ser Lys Thr Cys Leu Lys Glu Glu Met Ala Lys Gly 
            20                  25                  30          


Glu Ala Ser Glu Lys Ile Ile Ile Asn Val Gly Gly Thr Arg His Glu 
        35                  40                  45              


Thr Tyr Arg Ser Thr Leu Arg Thr Leu Pro Gly Thr Arg Leu Ala Trp 
    50                  55                  60                  


Leu Ala Asp Pro Asp Gly Gly Gly Arg Pro Glu Thr Asp Gly Gly Gly 
65                  70                  75                  80  


Val Gly Ser Ser Gly Ser Ser Gly Gly Gly Gly Cys Glu Phe Phe Phe 
                85                  90                  95      


Asp Arg His Pro Gly Val Phe Ala Tyr Val Leu Asn Tyr Tyr Arg Thr 
            100                 105                 110         


Gly Lys Leu His Cys Pro Ala Asp Val Cys Gly Pro Leu Phe Glu Glu 
        115                 120                 125             


Glu Leu Thr Phe Trp Gly Ile Asp Glu Thr Asp Val Glu Pro Cys Cys 
    130                 135                 140                 


Trp Met Thr Tyr Arg Gln His Arg Asp Ala Glu Glu Ala Leu Asp Ile 
145                 150                 155                 160 


Phe Glu Ser Pro Asp Gly Gly Gly Ser Gly Ala Gly Pro Ser Asp Glu 
                165                 170                 175     


Ala Gly Asp Asp Glu Arg Glu Leu Ala Leu Gln Arg Leu Gly Pro His 
            180                 185                 190         


Glu Gly Gly Ala Gly His Gly Ala Gly Ser Gly Gly Cys Arg Gly Trp 
        195                 200                 205             


Gln Pro Arg Met Trp Ala Leu Phe Glu Asp Pro Tyr Ser Ser Arg Ala 
    210                 215                 220                 


Ala Arg Val Val Ala Phe Ala Ser Leu Phe Phe Ile Leu Val Ser Ile 
225                 230                 235                 240 


Thr Thr Phe Cys Leu Glu Thr His Glu Ala Phe Asn Ile Asp Arg Asn 
                245                 250                 255     


Val Thr Glu Ile Leu Arg Val Gly Asn Ile Thr Ser Val His Phe Arg 
            260                 265                 270         


Arg Glu Val Glu Thr Glu Pro Ile Leu Thr Tyr Ile Glu Gly Val Cys 
        275                 280                 285             


Val Leu Trp Phe Thr Leu Glu Phe Leu Val Arg Ile Val Cys Cys Pro 
    290                 295                 300                 


Asp Thr Leu Asp Phe Val Lys Asn Leu Leu Asn Ile Ile Asp Phe Val 
305                 310                 315                 320 


Ala Ile Leu Pro Phe Tyr Leu Glu Val Gly Leu Ser Gly Leu Ser Ser 
                325                 330                 335     


Lys Ala Ala Arg Asp Val Leu Gly Phe Leu Arg Val Val Arg Phe Val 
            340                 345                 350         


Arg Ile Leu Arg Ile Phe Lys Leu Thr Arg His Phe Val Gly Leu Arg 
        355                 360                 365             


Val Leu Gly His Thr Leu Arg Ala Ser Thr Asn Glu Phe Leu Leu Leu 
    370                 375                 380                 


Ile Ile Phe Leu Ala Leu Gly Val Leu Ile Phe Ala Thr Met Ile Tyr 
385                 390                 395                 400 


Tyr Ala Glu Arg Ile Gly Ala Arg Pro Ser Asp Pro Arg Gly Asn Asp 
                405                 410                 415     


His Thr Asp Phe Lys Asn Ile Pro Ile Gly Phe Trp Trp Ala Val Val 
            420                 425                 430         


Thr Met Thr Thr Leu Gly Tyr Gly Asp Met Tyr Pro Lys Thr Trp Ser 
        435                 440                 445             


Gly Met Leu Val Gly Ala Leu Cys Ala Leu Ala Gly Val Leu Thr Ile 
    450                 455                 460                 


Ala Met Pro Val Pro Val Ile Val Asn Asn Phe Gly Met Tyr Tyr Ser 
465                 470                 475                 480 


Leu Ala Met Ala Lys Gln Lys Leu Pro Lys Lys Arg Lys Lys His Val 
                485                 490                 495     


Pro Arg Pro Ala Gln Leu Glu Ser Pro Met Tyr Cys Lys Ser Glu Glu 
            500                 505                 510         


Thr Ser Pro Arg Asp Ser Thr Cys Ser Asp Thr Ser Pro Pro Ala Arg 
        515                 520                 525             


Glu Glu Gly Met Ile Glu Arg Lys Arg Ala Asp Ser Lys Gln Asn Gly 
    530                 535                 540                 


Asp Ala Asn Ala Val Leu Ser Asp Glu Glu Gly Ala Gly Leu Thr Gln 
545                 550                 555                 560 


Pro Leu Ala Ser Ser Pro Thr Pro Glu Glu Arg Arg Ala Leu Arg Arg 
                565                 570                 575     


Ser Thr Thr Arg Asp Arg Asn Lys Lys Ala Ala Ala Cys Phe Leu Leu 
            580                 585                 590         


Ser Thr Gly Asp Tyr Ala Cys Ala Asp Gly Ser Val Arg Lys Glu Thr 
        595                 600                 605             


Cys Gln Asp Ala Leu Ser Ser Asn Tyr Ala Gln Ala Glu Val Leu Thr 
    610                 615                 620                 


Leu Ser 
625     


<210>  6226
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  6226

Met Phe Lys His Leu Arg Lys Trp Val Val Thr Arg Phe Phe Gly His 
1               5                   10                  15      


Ser Arg Gln Arg Ala Arg Leu Val Ser Lys Asp Gly Arg Cys Asn Ile 
            20                  25                  30          


Glu Phe Gly Asn Val Glu Ala Gln Ser Arg Phe Ile Phe Phe Val Asp 
        35                  40                  45              


Ile Trp Thr Thr Val Leu Asp Leu Lys Trp Arg Tyr Lys Met Thr Ile 
    50                  55                  60                  


Phe Ile Thr Ala Phe Leu Gly Ser Trp Phe Phe Phe Gly Leu Leu Trp 
65                  70                  75                  80  


Tyr Ala Val Ala Tyr Ile His Lys Asp Leu Pro Glu Phe His Pro Ser 
                85                  90                  95      


Ala Asn His Thr Pro Cys Val Glu Asn Ile Asn Gly Leu Thr Ser Ala 
            100                 105                 110         


Phe Leu Phe Ser Leu Glu Thr Gln Val Thr Ile Gly Tyr Gly Phe Arg 
        115                 120                 125             


Cys Val Thr Glu Gln Cys Ala Thr Ala Ile Phe Leu Leu Ile Phe Gln 
    130                 135                 140                 


Ser Ile Leu Gly Val Ile Ile Asn Ser Phe Met Cys Gly Ala Ile Leu 
145                 150                 155                 160 


Ala Lys Ile Ser Arg Pro Lys Lys Arg Ala Lys Thr Ile Thr Phe Ser 
                165                 170                 175     


Lys Asn Ala Val Ile Ser Lys Arg Gly Gly Lys Leu Cys Leu Leu Ile 
            180                 185                 190         


Arg Val Ala Asn Leu Arg Lys Ser Leu Leu Ile Gly Ser His Ile Tyr 
        195                 200                 205             


Gly Lys Leu Leu Lys Thr Thr Val Thr Pro Glu Gly Glu Thr Ile Ile 
    210                 215                 220                 


Leu Asp Gln Ile Asn Ile Asn Phe Val Val Asp Ala Gly Asn Glu Asn 
225                 230                 235                 240 


Leu Phe Phe Ile Ser Pro Leu Thr Ile Tyr His Val Ile Asp His Asn 
                245                 250                 255     


Ser Pro Phe Phe His Met Ala Ala Glu Thr Leu Leu Gln Gln Asp Phe 
            260                 265                 270         


Glu Leu Val Val Phe Leu Asp Gly Thr Val Glu Ser Thr Ser Ala Thr 
        275                 280                 285             


Cys Gln Val Arg Thr Ser Tyr Val Pro Glu Glu Val Leu Trp Gly Tyr 
    290                 295                 300                 


Arg Phe Ala Pro Ile Val Ser Lys Thr Lys Glu Gly Lys Tyr Arg Val 
305                 310                 315                 320 


Asp Phe His Asn Phe Ser Lys Thr Val Glu Val Glu Thr Pro His Cys 
                325                 330                 335     


Ala Met Cys Leu Tyr Asn Glu Lys Asp Val Arg Ala Arg Met Lys Arg 
            340                 345                 350         


Gly Tyr Asp Asn Pro Asn Phe Ile Leu Ser Glu Val Asn Glu Thr Asp 
        355                 360                 365             


Asp Thr Lys Met 
    370         


<210>  6227
<211>  389
<212>  PRT
<213>  Homo sapiens

<400>  6227

Met Pro Thr Val Tyr Leu Cys Ser Glu Gln Ile Arg Val Leu Thr Glu 
1               5                   10                  15      


Ser Met Phe Lys His Leu Arg Lys Trp Val Val Thr Arg Phe Phe Gly 
            20                  25                  30          


His Ser Arg Gln Arg Ala Arg Leu Val Ser Lys Asp Gly Arg Cys Asn 
        35                  40                  45              


Ile Glu Phe Gly Asn Val Glu Ala Gln Ser Arg Phe Ile Phe Phe Val 
    50                  55                  60                  


Asp Ile Trp Thr Thr Val Leu Asp Leu Lys Trp Arg Tyr Lys Met Thr 
65                  70                  75                  80  


Ile Phe Ile Thr Ala Phe Leu Gly Ser Trp Phe Phe Phe Gly Leu Leu 
                85                  90                  95      


Trp Tyr Ala Val Ala Tyr Ile His Lys Asp Leu Pro Glu Phe His Pro 
            100                 105                 110         


Ser Ala Asn His Thr Pro Cys Val Glu Asn Ile Asn Gly Leu Thr Ser 
        115                 120                 125             


Ala Phe Leu Phe Ser Leu Glu Thr Gln Val Thr Ile Gly Tyr Gly Phe 
    130                 135                 140                 


Arg Cys Val Thr Glu Gln Cys Ala Thr Ala Ile Phe Leu Leu Ile Phe 
145                 150                 155                 160 


Gln Ser Ile Leu Gly Val Ile Ile Asn Ser Phe Met Cys Gly Ala Ile 
                165                 170                 175     


Leu Ala Lys Ile Ser Arg Pro Lys Lys Arg Ala Lys Thr Ile Thr Phe 
            180                 185                 190         


Ser Lys Asn Ala Val Ile Ser Lys Arg Gly Gly Lys Leu Cys Leu Leu 
        195                 200                 205             


Ile Arg Val Ala Asn Leu Arg Lys Ser Leu Leu Ile Gly Ser His Ile 
    210                 215                 220                 


Tyr Gly Lys Leu Leu Lys Thr Thr Val Thr Pro Glu Gly Glu Thr Ile 
225                 230                 235                 240 


Ile Leu Asp Gln Ile Asn Ile Asn Phe Val Val Asp Ala Gly Asn Glu 
                245                 250                 255     


Asn Leu Phe Phe Ile Ser Pro Leu Thr Ile Tyr His Val Ile Asp His 
            260                 265                 270         


Asn Ser Pro Phe Phe His Met Ala Ala Glu Thr Leu Leu Gln Gln Asp 
        275                 280                 285             


Phe Glu Leu Val Val Phe Leu Asp Gly Thr Val Glu Ser Thr Ser Ala 
    290                 295                 300                 


Thr Cys Gln Val Arg Thr Ser Tyr Val Pro Glu Glu Val Leu Trp Gly 
305                 310                 315                 320 


Tyr Arg Phe Ala Pro Ile Val Ser Lys Thr Lys Glu Gly Lys Tyr Arg 
                325                 330                 335     


Val Asp Phe His Asn Phe Ser Lys Thr Val Glu Val Glu Thr Pro His 
            340                 345                 350         


Cys Ala Met Cys Leu Tyr Asn Glu Lys Asp Val Arg Ala Arg Met Lys 
        355                 360                 365             


Arg Gly Tyr Asp Asn Pro Asn Phe Ile Leu Ser Glu Val Asn Glu Thr 
    370                 375                 380                 


Asp Asp Thr Lys Met 
385                 


<210>  6228
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  6228

Met Phe Lys His Leu Arg Lys Trp Val Val Thr Arg Phe Phe Gly His 
1               5                   10                  15      


Ser Arg Gln Arg Ala Arg Leu Val Ser Lys Asp Gly Arg Cys Asn Ile 
            20                  25                  30          


Glu Phe Gly Asn Val Glu Ala Gln Ser Arg Phe Ile Phe Phe Val Asp 
        35                  40                  45              


Ile Trp Thr Thr Val Leu Asp Leu Lys Trp Arg Tyr Lys Met Thr Ile 
    50                  55                  60                  


Phe Ile Thr Ala Phe Leu Gly Ser Trp Phe Phe Phe Gly Leu Leu Trp 
65                  70                  75                  80  


Tyr Ala Val Ala Tyr Ile His Lys Asp Leu Pro Glu Phe His Pro Ser 
                85                  90                  95      


Ala Asn His Thr Pro Cys Val Glu Asn Ile Asn Gly Leu Thr Ser Ala 
            100                 105                 110         


Phe Leu Phe Ser Leu Glu Thr Gln Val Thr Ile Gly Tyr Gly Phe Arg 
        115                 120                 125             


Cys Val Thr Glu Gln Cys Ala Thr Ala Ile Phe Leu Leu Ile Phe Gln 
    130                 135                 140                 


Ser Ile Leu Gly Val Ile Ile Asn Ser Phe Met Cys Gly Ala Ile Leu 
145                 150                 155                 160 


Ala Lys Ile Ser Arg Pro Lys Lys Arg Ala Lys Thr Ile Thr Phe Ser 
                165                 170                 175     


Lys Asn Ala Val Ile Ser Lys Arg Gly Gly Lys Leu Cys Leu Leu Ile 
            180                 185                 190         


Arg Val Ala Asn Leu Arg Lys Ser Leu Leu Ile Gly Ser His Ile Tyr 
        195                 200                 205             


Gly Lys Leu Leu Lys Thr Thr Val Thr Pro Glu Gly Glu Thr Ile Ile 
    210                 215                 220                 


Leu Asp Gln Ile Asn Ile Asn Phe Val Val Asp Ala Gly Asn Glu Asn 
225                 230                 235                 240 


Leu Phe Phe Ile Ser Pro Leu Thr Ile Tyr His Val Ile Asp His Asn 
                245                 250                 255     


Ser Pro Phe Phe His Met Ala Ala Glu Thr Leu Leu Gln Gln Asp Phe 
            260                 265                 270         


Glu Leu Val Val Phe Leu Asp Gly Thr Val Glu Ser Thr Ser Ala Thr 
        275                 280                 285             


Cys Gln Val Arg Thr Ser Tyr Val Pro Glu Glu Val Leu Trp Gly Tyr 
    290                 295                 300                 


Arg Phe Ala Pro Ile Val Ser Lys Thr Lys Glu Gly Lys Tyr Arg Val 
305                 310                 315                 320 


Asp Phe His Asn Phe Ser Lys Thr Val Glu Val Glu Thr Pro His Cys 
                325                 330                 335     


Ala Met Cys Leu Tyr Asn Glu Lys Asp Val Arg Ala Arg Met Lys Arg 
            340                 345                 350         


Gly Tyr Asp Asn Pro Asn Phe Ile Leu Ser Glu Val Asn Glu Thr Asp 
        355                 360                 365             


Asp Thr Lys Met 
    370         


<210>  6229
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  6229

Met Phe Lys His Leu Arg Lys Trp Val Val Thr Arg Phe Phe Gly His 
1               5                   10                  15      


Ser Arg Gln Arg Ala Arg Leu Val Ser Lys Asp Gly Arg Cys Asn Ile 
            20                  25                  30          


Glu Phe Gly Asn Val Glu Ala Gln Ser Arg Phe Ile Phe Phe Val Asp 
        35                  40                  45              


Ile Trp Thr Thr Val Leu Asp Leu Lys Trp Arg Tyr Lys Met Thr Ile 
    50                  55                  60                  


Phe Ile Thr Ala Phe Leu Gly Ser Trp Phe Phe Phe Gly Leu Leu Trp 
65                  70                  75                  80  


Tyr Ala Val Ala Tyr Ile His Lys Asp Leu Pro Glu Phe His Pro Ser 
                85                  90                  95      


Ala Asn His Thr Pro Cys Val Glu Asn Ile Asn Gly Leu Thr Ser Ala 
            100                 105                 110         


Phe Leu Phe Ser Leu Glu Thr Gln Val Thr Ile Gly Tyr Gly Phe Arg 
        115                 120                 125             


Cys Val Thr Glu Gln Cys Ala Thr Ala Ile Phe Leu Leu Ile Phe Gln 
    130                 135                 140                 


Ser Ile Leu Gly Val Ile Ile Asn Ser Phe Met Cys Gly Ala Ile Leu 
145                 150                 155                 160 


Ala Lys Ile Ser Arg Pro Lys Lys Arg Ala Lys Thr Ile Thr Phe Ser 
                165                 170                 175     


Lys Asn Ala Val Ile Ser Lys Arg Gly Gly Lys Leu Cys Leu Leu Ile 
            180                 185                 190         


Arg Val Ala Asn Leu Arg Lys Ser Leu Leu Ile Gly Ser His Ile Tyr 
        195                 200                 205             


Gly Lys Leu Leu Lys Thr Thr Val Thr Pro Glu Gly Glu Thr Ile Ile 
    210                 215                 220                 


Leu Asp Gln Ile Asn Ile Asn Phe Val Val Asp Ala Gly Asn Glu Asn 
225                 230                 235                 240 


Leu Phe Phe Ile Ser Pro Leu Thr Ile Tyr His Val Ile Asp His Asn 
                245                 250                 255     


Ser Pro Phe Phe His Met Ala Ala Glu Thr Leu Leu Gln Gln Asp Phe 
            260                 265                 270         


Glu Leu Val Val Phe Leu Asp Gly Thr Val Glu Ser Thr Ser Ala Thr 
        275                 280                 285             


Cys Gln Val Arg Thr Ser Tyr Val Pro Glu Glu Val Leu Trp Gly Tyr 
    290                 295                 300                 


Arg Phe Ala Pro Ile Val Ser Lys Thr Lys Glu Gly Lys Tyr Arg Val 
305                 310                 315                 320 


Asp Phe His Asn Phe Ser Lys Thr Val Glu Val Glu Thr Pro His Cys 
                325                 330                 335     


Ala Met Cys Leu Tyr Asn Glu Lys Asp Val Arg Ala Arg Met Lys Arg 
            340                 345                 350         


Gly Tyr Asp Asn Pro Asn Phe Ile Leu Ser Glu Val Asn Glu Thr Asp 
        355                 360                 365             


Asp Thr Lys Met 
    370         


<210>  6230
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  6230

Met Glu Ala Ser Trp Gly Ser Phe Asn Ala Glu Arg Gly Trp Tyr Val 
1               5                   10                  15      


Ser Val Gln Gln Pro Glu Glu Ala Glu Ala Glu Glu Leu Ser Pro Leu 
            20                  25                  30          


Leu Ser Asn Glu Leu His Arg Gln Arg Ser Pro Gly Val Ser Phe Gly 
        35                  40                  45              


Leu Ser Val Phe Asn Leu Met Asn Ala Ile Met Gly Ser Gly Ile Leu 
    50                  55                  60                  


Gly Leu Ala Tyr Val Leu Ala Asn Thr Gly Val Phe Gly Phe Ser Phe 
65                  70                  75                  80  


Leu Leu Leu Thr Val Ala Leu Leu Ala Ser Tyr Ser Val His Leu Leu 
                85                  90                  95      


Leu Ser Met Cys Ile Gln Thr Ala Val Thr Ser Tyr Glu Asp Leu Gly 
            100                 105                 110         


Leu Phe Ala Phe Gly Leu Pro Gly Lys Leu Val Val Ala Gly Thr Ile 
        115                 120                 125             


Ile Ile Gln Asn Ile Gly Ala Met Ser Ser Tyr Leu Leu Ile Ile Lys 
    130                 135                 140                 


Thr Glu Leu Pro Ala Ala Ile Ala Glu Phe Leu Thr Gly Asp Tyr Ser 
145                 150                 155                 160 


Arg Tyr Trp Tyr Leu Asp Gly Gln Thr Leu Leu Ile Ile Ile Cys Val 
                165                 170                 175     


Gly Ile Val Phe Pro Leu Ala Leu Leu Pro Lys Ile Gly Phe Leu Gly 
            180                 185                 190         


Tyr Thr Ser Ser Leu Ser Phe Phe Phe Met Met Phe Phe Ala Leu Val 
        195                 200                 205             


Val Ile Ile Lys Lys Trp Ser Ile Pro Cys Pro Leu Thr Leu Asn Tyr 
    210                 215                 220                 


Val Glu Lys Gly Phe Gln Ile Ser Asn Val Thr Asp Asp Cys Lys Pro 
225                 230                 235                 240 


Lys Leu Phe His Phe Ser Lys Glu Ser Ala Tyr Ala Leu Pro Thr Met 
                245                 250                 255     


Ala Phe Ser Phe Leu Cys His Thr Ser Ile Leu Pro Ile Tyr Cys Glu 
            260                 265                 270         


Leu Gln Ser Pro Ser Lys Lys Arg Met Gln Asn Val Thr Asn Thr Ala 
        275                 280                 285             


Ile Ala Leu Ser Phe Leu Ile Tyr Phe Ile Ser Ala Leu Phe Gly Tyr 
    290                 295                 300                 


Leu Thr Phe Tyr Asp Lys Val Glu Ser Glu Leu Leu Lys Gly Tyr Ser 
305                 310                 315                 320 


Lys Tyr Leu Ser His Asp Val Val Val Met Thr Val Lys Leu Cys Ile 
                325                 330                 335     


Leu Phe Ala Val Leu Leu Thr Val Pro Leu Ile His Phe Pro Ala Arg 
            340                 345                 350         


Lys Ala Val Thr Met Met Phe Phe Ser Asn Phe Pro Phe Ser Trp Ile 
        355                 360                 365             


Arg His Phe Leu Ile Thr Leu Ala Leu Asn Ile Ile Ile Val Leu Leu 
    370                 375                 380                 


Ala Ile Tyr Val Pro Asp Ile Arg Asn Val Phe Gly Val Val Gly Ala 
385                 390                 395                 400 


Ser Thr Ser Thr Cys Leu Ile Phe Ile Phe Pro Gly Leu Phe Tyr Leu 
                405                 410                 415     


Lys Leu Ser Arg Glu Asp Phe Leu Ser Trp Lys Lys Leu Gly Ala Phe 
            420                 425                 430         


Val Leu Leu Ile Phe Gly Ile Leu Val Gly Asn Phe Ser Leu Ala Leu 
        435                 440                 445             


Ile Ile Phe Asp Trp Ile Asn Lys 
    450                 455     


<210>  6231
<211>  946
<212>  PRT
<213>  Homo sapiens

<400>  6231

Met Val Pro Trp Val Arg Thr Met Gly Gln Lys Leu Lys Gln Arg Leu 
1               5                   10                  15      


Arg Leu Asp Val Gly Arg Glu Ile Cys Arg Gln Tyr Pro Leu Phe Cys 
            20                  25                  30          


Phe Leu Leu Leu Cys Leu Ser Ala Ala Ser Leu Leu Leu Asn Arg Tyr 
        35                  40                  45              


Ile His Ile Leu Met Ile Phe Trp Ser Phe Val Ala Gly Val Val Thr 
    50                  55                  60                  


Phe Tyr Cys Ser Leu Gly Pro Asp Ser Leu Leu Pro Asn Ile Phe Phe 
65                  70                  75                  80  


Thr Ile Lys Tyr Lys Pro Lys Gln Leu Gly Leu Gln Glu Leu Phe Pro 
                85                  90                  95      


Gln Gly His Ser Cys Ala Val Cys Gly Lys Val Lys Cys Lys Arg His 
            100                 105                 110         


Arg Pro Ser Leu Leu Leu Glu Asn Tyr Gln Pro Trp Leu Asp Leu Lys 
        115                 120                 125             


Ile Ser Ser Lys Val Asp Ala Ser Leu Ser Glu Val Leu Glu Leu Val 
    130                 135                 140                 


Leu Glu Asn Phe Val Tyr Pro Trp Tyr Arg Asp Val Thr Asp Asp Glu 
145                 150                 155                 160 


Ser Phe Val Asp Glu Leu Arg Ile Thr Leu Arg Phe Phe Ala Ser Val 
                165                 170                 175     


Leu Ile Arg Arg Ile His Lys Val Asp Ile Pro Ser Ile Ile Thr Lys 
            180                 185                 190         


Lys Leu Leu Lys Ala Ala Met Lys His Ile Glu Val Ile Val Lys Ala 
        195                 200                 205             


Arg Gln Lys Val Lys Asn Thr Glu Phe Leu Gln Gln Ala Ala Leu Glu 
    210                 215                 220                 


Glu Tyr Gly Pro Glu Leu His Val Ala Leu Arg Ser Arg Arg Asp Glu 
225                 230                 235                 240 


Leu His Tyr Leu Arg Lys Leu Thr Glu Leu Leu Phe Pro Tyr Ile Leu 
                245                 250                 255     


Pro Pro Lys Ala Thr Asp Cys Arg Ser Leu Thr Leu Leu Ile Arg Glu 
            260                 265                 270         


Ile Leu Ser Gly Ser Val Phe Leu Pro Ser Leu Asp Phe Leu Ala Asp 
        275                 280                 285             


Pro Asp Thr Val Asn His Leu Leu Ile Ile Phe Ile Asp Asp Ser Pro 
    290                 295                 300                 


Pro Glu Lys Ala Thr Glu Pro Ala Ser Pro Leu Val Pro Phe Leu Gln 
305                 310                 315                 320 


Lys Phe Ala Glu Pro Arg Asn Lys Lys Pro Ser Val Leu Lys Leu Glu 
                325                 330                 335     


Leu Lys Gln Ile Arg Glu Gln Gln Asp Leu Leu Phe Arg Phe Met Asn 
            340                 345                 350         


Phe Leu Lys Gln Glu Gly Ala Val His Val Leu Gln Phe Cys Leu Thr 
        355                 360                 365             


Val Glu Glu Phe Asn Asp Arg Ile Leu Arg Pro Glu Leu Ser Asn Asp 
    370                 375                 380                 


Glu Met Leu Ser Leu His Glu Glu Leu Gln Lys Ile Tyr Lys Thr Tyr 
385                 390                 395                 400 


Cys Leu Asp Glu Ser Ile Asp Lys Ile Arg Phe Asp Pro Phe Ile Val 
                405                 410                 415     


Glu Glu Ile Gln Arg Ile Ala Glu Gly Pro Tyr Ile Asp Val Val Lys 
            420                 425                 430         


Leu Gln Thr Met Arg Cys Leu Phe Glu Ala Tyr Glu His Val Leu Ser 
        435                 440                 445             


Leu Leu Glu Asn Val Phe Thr Pro Met Phe Cys His Ser Asp Glu Tyr 
    450                 455                 460                 


Phe Arg Gln Leu Leu Arg Gly Ala Glu Ser Pro Thr Arg Asn Ser Lys 
465                 470                 475                 480 


Leu Asn Arg Gly Ser Leu Ser Leu Asp Asp Phe Arg Asn Thr Gln Lys 
                485                 490                 495     


Arg Gly Glu Ser Phe Gly Ile Ser Arg Ile Gly Ser Lys Ile Lys Gly 
            500                 505                 510         


Val Phe Lys Ser Thr Thr Met Glu Gly Ala Met Leu Pro Asn Tyr Gly 
        515                 520                 525             


Val Ala Glu Gly Glu Asp Asp Phe Ile Glu Glu Gly Ile Val Val Met 
    530                 535                 540                 


Glu Asp Asp Ser Pro Val Glu Ala Val Ser Thr Pro Asn Thr Pro Arg 
545                 550                 555                 560 


Asn Leu Ala Ala Trp Lys Ile Ser Ile Pro Tyr Val Asp Phe Phe Glu 
                565                 570                 575     


Asp Pro Ser Ser Glu Arg Lys Glu Lys Lys Glu Arg Ile Pro Val Phe 
            580                 585                 590         


Cys Ile Asp Val Glu Arg Asn Asp Arg Arg Ala Val Gly His Glu Pro 
        595                 600                 605             


Glu His Trp Ser Val Tyr Arg Arg Tyr Leu Glu Phe Tyr Val Leu Glu 
    610                 615                 620                 


Ser Lys Leu Thr Glu Phe His Gly Ala Phe Pro Asp Ala Gln Leu Pro 
625                 630                 635                 640 


Ser Lys Arg Ile Ile Gly Pro Lys Asn Tyr Glu Phe Leu Lys Ser Lys 
                645                 650                 655     


Arg Glu Glu Phe Gln Glu Tyr Leu Gln Lys Leu Leu Gln His Pro Glu 
            660                 665                 670         


Leu Ser Asn Ser Gln Leu Leu Ala Asp Phe Leu Ser Pro Asn Gly Gly 
        675                 680                 685             


Glu Thr Gln Phe Leu Asp Lys Ile Leu Pro Asp Val Asn Leu Gly Lys 
    690                 695                 700                 


Ile Ile Lys Ser Val Pro Gly Lys Leu Met Lys Glu Lys Gly Gln His 
705                 710                 715                 720 


Leu Glu Pro Phe Ile Met Asn Phe Ile Asn Ser Cys Glu Ser Pro Lys 
                725                 730                 735     


Pro Lys Pro Ser Arg Pro Glu Leu Thr Ile Leu Ser Pro Thr Ser Glu 
            740                 745                 750         


Asn Asn Lys Lys Leu Phe Asn Asp Leu Phe Lys Asn Asn Ala Asn Arg 
        755                 760                 765             


Ala Glu Asn Thr Glu Arg Lys Gln Asn Gln Asn Tyr Phe Met Glu Val 
    770                 775                 780                 


Met Thr Val Glu Gly Val Tyr Asp Tyr Leu Met Tyr Val Gly Arg Val 
785                 790                 795                 800 


Val Phe Gln Val Pro Asp Trp Leu His His Leu Leu Met Gly Thr Arg 
                805                 810                 815     


Ile Leu Phe Lys Asn Thr Leu Glu Met Tyr Thr Asp Tyr Tyr Leu Gln 
            820                 825                 830         


Cys Lys Leu Glu Gln Leu Phe Gln Glu His Arg Leu Val Ser Leu Ile 
        835                 840                 845             


Thr Leu Leu Arg Asp Ala Ile Phe Cys Glu Asn Thr Glu Pro Arg Ser 
    850                 855                 860                 


Leu Gln Asp Lys Gln Lys Gly Ala Lys Gln Thr Phe Glu Glu Met Met 
865                 870                 875                 880 


Asn Tyr Ile Pro Asp Leu Leu Val Lys Cys Ile Gly Glu Glu Thr Lys 
                885                 890                 895     


Tyr Glu Ser Ile Arg Leu Leu Phe Asp Gly Leu Gln Gln Pro Val Leu 
            900                 905                 910         


Asn Lys Gln Leu Thr Tyr Val Leu Leu Asp Ile Val Ile Gln Glu Leu 
        915                 920                 925             


Phe Pro Glu Leu Asn Lys Val Gln Lys Glu Val Thr Ser Val Thr Ser 
    930                 935                 940                 


Trp Met 
945     


<210>  6232
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  6232

Met Ala Pro Ala Ala Ala Ser Pro Pro Glu Val Ile Arg Ala Ala Gln 
1               5                   10                  15      


Lys Asp Glu Tyr Tyr Arg Gly Gly Leu Arg Ser Ala Ala Gly Gly Ala 
            20                  25                  30          


Leu His Ser Leu Ala Gly Ala Arg Lys Trp Leu Glu Trp Arg Lys Glu 
        35                  40                  45              


Val Glu Leu Leu Ser Asp Val Ala Tyr Phe Gly Leu Thr Thr Leu Ala 
    50                  55                  60                  


Gly Tyr Gln Thr Leu Gly Glu Glu Tyr Val Ser Ile Ile Gln Val Asp 
65                  70                  75                  80  


Pro Ser Arg Ile His Val Pro Ser Ser Leu Arg Arg Gly Val Leu Val 
                85                  90                  95      


Thr Leu His Ala Val Leu Pro Tyr Leu Leu Asp Lys Ala Leu Leu Pro 
            100                 105                 110         


Leu Glu Gln Glu Leu Gln Ala Asp Pro Asp Ser Gly Arg Pro Leu Gln 
        115                 120                 125             


Gly Ser Leu Gly Pro Gly Gly Arg Gly Cys Ser Gly Ala Arg Arg Trp 
    130                 135                 140                 


Met Arg His His Thr Ala Thr Leu Thr Glu Gln Gln Arg Arg Ala Leu 
145                 150                 155                 160 


Leu Arg Ala Val Phe Val Leu Arg Gln Gly Leu Ala Cys Leu Gln Arg 
                165                 170                 175     


Leu His Val Ala Trp Phe Tyr Ile His Gly Val Phe Tyr His Leu Ala 
            180                 185                 190         


Lys Arg Leu Thr Gly Ile Thr Tyr Gln Ala Leu Arg Pro Asp Pro Leu 
        195                 200                 205             


Arg Val Leu Met Ser Val Ala Pro Ser Ala Leu Gln Leu Arg Val Arg 
    210                 215                 220                 


Ser Leu Pro Gly Glu Asp Leu Arg Ala Arg Val Ser Tyr Arg Leu Leu 
225                 230                 235                 240 


Gly Val Ile Ser Leu Leu His Leu Val Leu Ser Met Gly Leu Gln Leu 
                245                 250                 255     


Tyr Gly Phe Arg Gln Arg Gln Arg Ala Arg Lys Glu Trp Arg Leu His 
            260                 265                 270         


Arg Gly Leu Ser His Arg Arg Ala Ser Leu Glu Glu Arg Ala Val Ser 
        275                 280                 285             


Arg Asn Pro Leu Cys Thr Leu Cys Leu Glu Glu Arg Arg His Pro Thr 
    290                 295                 300                 


Ala Thr Pro Cys Gly His Leu Phe Cys Trp Glu Cys Ile Thr Ala Trp 
305                 310                 315                 320 


Cys Ser Ser Lys Ala Glu Cys Pro Leu Cys Arg Glu Lys Phe Pro Pro 
                325                 330                 335     


Gln Lys Leu Ile Tyr Leu Arg His Tyr Arg 
            340                 345     


<210>  6233
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  6233

Met Ala Lys Met Glu Leu Ser Lys Ala Phe Ser Gly Gln Arg Thr Leu 
1               5                   10                  15      


Leu Ser Ala Ile Leu Ser Met Leu Ser Leu Ser Phe Ser Thr Thr Ser 
            20                  25                  30          


Leu Leu Ser Asn Tyr Trp Phe Val Gly Thr Gln Lys Val Pro Lys Pro 
        35                  40                  45              


Leu Cys Glu Lys Gly Leu Ala Ala Lys Cys Phe Asp Met Pro Val Ser 
    50                  55                  60                  


Leu Asp Gly Asp Thr Asn Thr Ser Thr Gln Glu Val Val Gln Tyr Asn 
65                  70                  75                  80  


Trp Glu Thr Gly Asp Asp Arg Phe Ser Phe Arg Ser Phe Arg Ser Gly 
                85                  90                  95      


Met Trp Leu Ser Cys Glu Glu Thr Val Glu Glu Pro Gly Glu Arg Cys 
            100                 105                 110         


Arg Ser Phe Ile Glu Leu Thr Pro Pro Ala Lys Arg Glu Ile Leu Trp 
        115                 120                 125             


Leu Ser Leu Gly Thr Gln Ile Thr Tyr Ile Gly Leu Gln Phe Ile Ser 
    130                 135                 140                 


Phe Leu Leu Leu Leu Thr Asp Leu Leu Leu Thr Gly Asn Pro Ala Cys 
145                 150                 155                 160 


Gly Leu Lys Leu Ser Ala Phe Ala Ala Val Ser Ser Val Leu Ser Gly 
                165                 170                 175     


Leu Leu Gly Met Val Ala His Met Met Tyr Ser Gln Val Phe Gln Ala 
            180                 185                 190         


Thr Val Asn Leu Gly Pro Glu Asp Trp Arg Pro His Val Trp Asn Tyr 
        195                 200                 205             


Gly Trp Ala Phe Tyr Met Ala Trp Leu Ser Phe Thr Cys Cys Met Ala 
    210                 215                 220                 


Ser Ala Val Thr Thr Phe Asn Thr Tyr Thr Arg Met Val Leu Glu Phe 
225                 230                 235                 240 


Lys Cys Lys His Ser Lys Ser Phe Lys Glu Asn Pro Asn Cys Leu Pro 
                245                 250                 255     


His His His Gln Cys Phe Pro Arg Arg Leu Ser Ser Ala Ala Pro Thr 
            260                 265                 270         


Val Gly Pro Leu Thr Ser Tyr His Gln Tyr His Asn Gln Pro Ile His 
        275                 280                 285             


Ser Val Ser Glu Gly Val Asp Phe Tyr Ser Glu Leu Arg Asn Lys Gly 
    290                 295                 300                 


Phe Gln Arg Gly Ala Ser Gln Glu Leu Lys Glu Ala Val Arg Ser Ser 
305                 310                 315                 320 


Val Glu Glu Glu Gln Cys 
                325     


<210>  6234
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  6234

Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Asp Ala Cys Glu Glu Pro Pro Thr Phe Glu Ala Met Glu Leu Ile Gly 
        35                  40                  45              


Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys 
    50                  55                  60                  


Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Thr His Thr Ile Cys 
65                  70                  75                  80  


Asp Arg Asn His Thr Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg 
                85                  90                  95      


Glu Thr Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
            100                 105                 110         


Ala Asn Gly Thr Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
        115                 120                 125             


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
    130                 135                 140                 


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
145                 150                 155                 160 


Leu Cys Thr Pro Pro Pro Lys Ile Lys Asn Gly Lys His Thr Phe Ser 
                165                 170                 175     


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Thr Tyr Ser Cys Asp 
            180                 185                 190         


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Thr Ile 
        195                 200                 205             


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
    210                 215                 220                 


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
225                 230                 235                 240 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Thr Val Met Phe Glu Cys 
                245                 250                 255     


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Thr Ile Val Cys Asp Ser 
            260                 265                 270         


Asn Ser Thr Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Val Ser Thr 
        275                 280                 285             


Ser Ser Thr Thr Lys Ser Pro Ala Ser Ser Ala Ser Gly Pro Arg Pro 
    290                 295                 300                 


Thr Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro Glu 
305                 310                 315                 320 


Glu Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val Ile Val 
                325                 330                 335     


Ile Ala Ile Val Val Gly Val Ala Val Ile Cys Val Val Pro Tyr Arg 
            340                 345                 350         


Tyr Leu Gln Arg Arg Lys Lys Lys Gly Lys Ala Asp Gly Gly Ala Glu 
        355                 360                 365             


Tyr Ala Thr Tyr Gln Thr Lys Ser Thr Thr Pro Ala Glu Gln Arg Gly 
    370                 375                 380                 


<210>  6235
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  6235

Met Glu Asp Leu Asp Gln Ser Pro Leu Val Ser Ser Ser Asp Ser Pro 
1               5                   10                  15      


Pro Arg Pro Gln Pro Ala Phe Lys Tyr Gln Phe Val Arg Glu Pro Glu 
            20                  25                  30          


Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Glu Asp 
        35                  40                  45              


Leu Glu Glu Leu Glu Val Leu Glu Arg Lys Pro Ala Ala Gly Leu Ser 
    50                  55                  60                  


Ala Ala Pro Val Pro Thr Ala Pro Ala Ala Gly Ala Pro Leu Met Asp 
65                  70                  75                  80  


Phe Gly Asn Asp Phe Val Pro Pro Ala Pro Arg Gly Pro Leu Pro Ala 
                85                  90                  95      


Ala Pro Pro Val Ala Pro Glu Arg Gln Pro Ser Trp Asp Pro Ser Pro 
            100                 105                 110         


Val Ser Ser Thr Val Pro Ala Pro Ser Pro Leu Ser Ala Ala Ala Val 
        115                 120                 125             


Ser Pro Ser Lys Leu Pro Glu Asp Asp Glu Pro Pro Ala Arg Pro Pro 
    130                 135                 140                 


Pro Pro Pro Pro Ala Ser Val Ser Pro Gln Ala Glu Pro Val Trp Thr 
145                 150                 155                 160 


Pro Pro Ala Pro Ala Pro Ala Ala Pro Pro Ser Thr Pro Ala Ala Pro 
                165                 170                 175     


Lys Arg Arg Gly Ser Ser Gly Ser Val Val Val Asp Leu Leu Tyr Trp 
            180                 185                 190         


Arg Asp Ile Lys Lys Thr Gly Val Val Phe Gly Ala Ser Leu Phe Leu 
        195                 200                 205             


Leu Leu Ser Leu Thr Val Phe Ser Ile Val Ser Val Thr Ala Tyr Ile 
    210                 215                 220                 


Ala Leu Ala Leu Leu Ser Val Thr Ile Ser Phe Arg Ile Tyr Lys Gly 
225                 230                 235                 240 


Val Ile Gln Ala Ile Gln Lys Ser Asp Glu Gly His Pro Phe Arg Ala 
                245                 250                 255     


Tyr Leu Glu Ser Glu Val Ala Ile Ser Glu Glu Leu Val Gln Lys Tyr 
            260                 265                 270         


Ser Asn Ser Ala Leu Gly His Val Asn Cys Thr Ile Lys Glu Leu Arg 
        275                 280                 285             


Arg Leu Phe Leu Val Asp Asp Leu Val Asp Ser Leu Lys Phe Ala Val 
    290                 295                 300                 


Leu Met Trp Val Phe Thr Tyr Val Gly Ala Leu Phe Asn Gly Leu Thr 
305                 310                 315                 320 


Leu Leu Ile Leu Ala Leu Ile Ser Leu Phe Ser Val Pro Val Ile Tyr 
                325                 330                 335     


Glu Arg His Gln Ala Gln Ile Asp His Tyr Leu Gly Leu Ala Asn Lys 
            340                 345                 350         


Asn Val Lys Asp Ala Met Ala Lys Ile Gln Ala Lys Ile Pro Gly Leu 
        355                 360                 365             


Lys Arg Lys Ala Glu 
    370             


<210>  6236
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  6236

Met Ser Leu Asn Ser Ser Leu Ser Cys Arg Lys Glu Leu Ser Asn Leu 
1               5                   10                  15      


Thr Glu Glu Glu Gly Gly Glu Gly Gly Val Ile Ile Thr Gln Phe Ile 
            20                  25                  30          


Ala Ile Ile Val Ile Thr Ile Phe Val Cys Leu Gly Asn Leu Val Ile 
        35                  40                  45              


Val Val Thr Leu Tyr Lys Lys Ser Tyr Leu Leu Thr Leu Ser Asn Lys 
    50                  55                  60                  


Phe Val Phe Ser Leu Thr Leu Ser Asn Phe Leu Leu Ser Val Leu Val 
65                  70                  75                  80  


Leu Pro Phe Val Val Thr Ser Ser Ile Arg Arg Glu Trp Ile Phe Gly 
                85                  90                  95      


Val Val Trp Cys Asn Phe Ser Ala Leu Leu Tyr Leu Leu Ile Ser Ser 
            100                 105                 110         


Ala Ser Met Leu Thr Leu Gly Val Ile Ala Ile Asp Arg Tyr Tyr Ala 
        115                 120                 125             


Val Leu Tyr Pro Met Val Tyr Pro Met Lys Ile Thr Gly Asn Arg Ala 
    130                 135                 140                 


Val Met Ala Leu Val Tyr Ile Trp Leu His Ser Leu Ile Gly Cys Leu 
145                 150                 155                 160 


Pro Pro Leu Phe Gly Trp Ser Ser Val Glu Phe Asp Glu Phe Lys Trp 
                165                 170                 175     


Met Cys Val Ala Ala Trp His Arg Glu Pro Gly Tyr Thr Ala Phe Trp 
            180                 185                 190         


Gln Ile Trp Cys Ala Leu Phe Pro Phe Leu Val Met Leu Val Cys Tyr 
        195                 200                 205             


Gly Phe Ile Phe Arg Val Ala Arg Val Lys Ala Arg Lys Val His Cys 
    210                 215                 220                 


Gly Thr Val Val Ile Val Glu Glu Asp Ala Gln Arg Thr Gly Arg Lys 
225                 230                 235                 240 


Asn Ser Ser Thr Ser Thr Ser Ser Ser Gly Ser Arg Arg Asn Ala Phe 
                245                 250                 255     


Gln Gly Val Val Tyr Ser Ala Asn Gln Cys Lys Ala Leu Ile Thr Ile 
            260                 265                 270         


Leu Val Val Leu Gly Ala Phe Met Val Thr Trp Gly Pro Tyr Met Val 
        275                 280                 285             


Val Ile Ala Ser Glu Ala Leu Trp Gly Lys Ser Ser Val Ser Pro Ser 
    290                 295                 300                 


Leu Glu Thr Trp Ala Thr Trp Leu Ser Phe Ala Ser Ala Val Cys His 
305                 310                 315                 320 


Pro Leu Ile Tyr Gly Leu Trp Asn Lys Thr Val Arg Lys Glu Leu Leu 
                325                 330                 335     


Gly Met Cys Phe Gly Asp Arg Tyr Tyr Arg Glu Pro Phe Val Gln Arg 
            340                 345                 350         


Gln Arg Thr Ser Arg Leu Phe Ser Ile Ser Asn Arg Ile Thr Asp Leu 
        355                 360                 365             


Gly Leu Ser Pro His Leu Thr Ala Leu Met Ala Gly Gly Gln Pro Leu 
    370                 375                 380                 


Gly His Ser Ser Ser Thr Gly Asp Thr Gly Phe Ser Cys Ser Gln Asp 
385                 390                 395                 400 


Ser Gly Thr Asp Met Met Leu Leu Glu Asp Tyr Thr Ser Asp Asp Asn 
                405                 410                 415     


Pro Pro Ser His Cys Thr Cys Pro Pro Lys Arg Arg Ser Ser Val Thr 
            420                 425                 430         


Phe Glu Asp Glu Val Glu Gln Ile Lys Glu Ala Ala Lys Asn Ser Ile 
        435                 440                 445             


Leu His Val Lys Ala Glu Val His Lys Ser Leu Asp Ser Tyr Ala Ala 
    450                 455                 460                 


Ser Leu Ala Lys Ala Ile Glu Ala Glu Ala Lys Ile Asn Leu Phe Gly 
465                 470                 475                 480 


Glu Glu Ala Leu Pro Gly Val Leu Val Thr Ala Arg Thr Val Pro Gly 
                485                 490                 495     


Gly Gly Phe Gly Gly Arg Arg Gly Ser Arg Thr Leu Val Ser Gln Arg 
            500                 505                 510         


Leu Gln Leu Gln Ser Ile Glu Glu Gly Asp Val Leu Ala Ala Glu Gln 
        515                 520                 525             


Arg 
    


<210>  6237
<211>  3080
<212>  PRT
<213>  Homo sapiens

<400>  6237

Met Lys Glu His Ile Ile Tyr Gln Lys Leu Tyr Gly Leu Ile Leu Met 
1               5                   10                  15      


Ser Ser Phe Ile Phe Leu Ser Asp Thr Leu Ser Leu Lys Gly Lys Lys 
            20                  25                  30          


Leu Asp Phe Phe Gly Arg Gly Asp Thr Tyr Val Ser Leu Ile Asp Thr 
        35                  40                  45              


Ile Pro Glu Leu Ser Arg Phe Thr Ala Cys Ile Asp Leu Val Phe Met 
    50                  55                  60                  


Asp Asp Asn Ser Arg Tyr Trp Met Ala Phe Ser Tyr Ile Thr Asn Asn 
65                  70                  75                  80  


Ala Leu Leu Gly Arg Glu Asp Ile Asp Leu Gly Leu Ala Gly Asp His 
                85                  90                  95      


Gln Gln Leu Ile Leu Tyr Arg Leu Gly Lys Thr Phe Ser Ile Arg His 
            100                 105                 110         


His Leu Ala Ser Phe Gln Trp His Thr Ile Cys Leu Ile Trp Asp Gly 
        115                 120                 125             


Val Lys Gly Lys Leu Glu Leu Phe Leu Asn Lys Glu Arg Ile Leu Glu 
    130                 135                 140                 


Val Thr Asp Gln Pro His Asn Leu Thr Pro His Gly Thr Leu Phe Leu 
145                 150                 155                 160 


Gly His Phe Leu Lys Asn Glu Ser Ser Glu Val Lys Ser Met Met Arg 
                165                 170                 175     


Ser Phe Pro Gly Ser Leu Tyr Tyr Phe Gln Leu Trp Asp His Ile Leu 
            180                 185                 190         


Glu Asn Glu Glu Phe Met Lys Cys Leu Asp Gly Asn Ile Val Ser Trp 
        195                 200                 205             


Glu Glu Asp Val Trp Leu Val Asn Lys Ile Ile Pro Thr Val Asp Arg 
    210                 215                 220                 


Thr Leu Arg Cys Phe Val Pro Glu Asn Met Thr Ile Gln Glu Lys Ser 
225                 230                 235                 240 


Thr Thr Val Ser Gln Gln Ile Asp Met Thr Thr Pro Ser Gln Ile Thr 
                245                 250                 255     


Gly Val Lys Pro Gln Asn Thr Ala His Ser Ser Thr Leu Leu Ser Gln 
            260                 265                 270         


Ser Ile Pro Ile Phe Ala Thr Asp Tyr Thr Thr Ile Ser Tyr Ser Asn 
        275                 280                 285             


Thr Thr Ser Pro Pro Leu Glu Thr Met Thr Ala Gln Lys Ile Leu Lys 
    290                 295                 300                 


Thr Leu Val Asp Glu Thr Ala Thr Phe Ala Val Asp Val Leu Ser Thr 
305                 310                 315                 320 


Ser Ser Ala Ile Ser Leu Pro Thr Gln Ser Ile Ser Ile Asp Asn Thr 
                325                 330                 335     


Thr Asn Ser Met Lys Lys Thr Lys Ser Pro Ser Ser Glu Ser Thr Lys 
            340                 345                 350         


Thr Thr Lys Met Val Glu Ala Met Ala Thr Glu Ile Phe Gln Pro Pro 
        355                 360                 365             


Thr Pro Ser Asn Phe Leu Ser Thr Ser Arg Phe Thr Lys Asn Ser Val 
    370                 375                 380                 


Val Ser Thr Thr Ser Ala Ile Lys Ser Gln Ser Ala Val Thr Lys Thr 
385                 390                 395                 400 


Thr Ser Leu Phe Ser Thr Ile Glu Ser Thr Ser Met Ser Thr Thr Pro 
                405                 410                 415     


Cys Leu Lys Gln Lys Ser Thr Asn Thr Gly Ala Leu Pro Ile Ser Thr 
            420                 425                 430         


Ala Gly Gln Glu Phe Ile Glu Ser Thr Ala Ala Gly Thr Val Pro Trp 
        435                 440                 445             


Phe Thr Val Glu Lys Thr Ser Pro Ala Ser Thr His Val Gly Thr Ala 
    450                 455                 460                 


Ser Ser Phe Pro Pro Glu Pro Val Leu Ile Ser Thr Ala Ala Pro Val 
465                 470                 475                 480 


Asp Ser Val Phe Pro Arg Asn Gln Thr Ala Phe Pro Leu Ala Thr Thr 
                485                 490                 495     


Asp Met Lys Ile Ala Phe Thr Val His Ser Leu Thr Leu Pro Thr Arg 
            500                 505                 510         


Leu Ile Glu Thr Thr Pro Ala Pro Arg Thr Ala Glu Thr Glu Leu Thr 
        515                 520                 525             


Ser Thr Asn Phe Gln Asp Val Ser Leu Pro Arg Val Glu Asp Ala Met 
    530                 535                 540                 


Ser Thr Ser Met Ser Lys Glu Thr Ser Ser Lys Thr Phe Ser Phe Leu 
545                 550                 555                 560 


Thr Ser Phe Ser Phe Thr Gly Thr Glu Ser Val Gln Thr Val Ile Asp 
                565                 570                 575     


Ala Glu Ala Thr Arg Thr Ala Leu Thr Pro Glu Ile Thr Leu Ala Ser 
            580                 585                 590         


Thr Val Ala Glu Thr Met Leu Ser Ser Thr Ile Thr Gly Arg Val Tyr 
        595                 600                 605             


Thr Gln Asn Thr Pro Thr Ala Asp Gly His Leu Leu Thr Leu Met Ser 
    610                 615                 620                 


Thr Arg Ser Ala Ser Thr Ser Lys Ala Pro Glu Ser Gly Pro Thr Ser 
625                 630                 635                 640 


Thr Thr Asp Glu Ala Ala His Leu Phe Ser Ser Asn Glu Thr Ile Trp 
                645                 650                 655     


Thr Ser Arg Pro Asp Gln Ala Leu Leu Ala Ser Met Asn Thr Thr Thr 
            660                 665                 670         


Ile Leu Thr Phe Val Pro Asn Glu Asn Phe Thr Ser Ala Phe His Glu 
        675                 680                 685             


Asn Thr Thr Tyr Thr Glu Tyr Leu Ser Ala Thr Thr Asn Ile Thr Pro 
    690                 695                 700                 


Leu Lys Ala Ser Pro Glu Gly Lys Gly Thr Thr Ala Asn Asp Ala Thr 
705                 710                 715                 720 


Thr Ala Arg Tyr Thr Thr Ala Val Ser Lys Leu Thr Ser Pro Trp Phe 
                725                 730                 735     


Ala Asn Phe Ser Ile Val Ser Gly Thr Thr Ser Ile Thr Asn Met Pro 
            740                 745                 750         


Glu Phe Lys Leu Thr Thr Leu Leu Leu Lys Thr Ile Pro Met Ser Thr 
        755                 760                 765             


Lys Pro Ala Asn Glu Leu Pro Leu Thr Pro Arg Glu Thr Val Val Pro 
    770                 775                 780                 


Ser Val Asp Ile Ile Ser Thr Leu Ala Cys Ile Gln Pro Asn Phe Ser 
785                 790                 795                 800 


Thr Glu Glu Ser Ala Ser Glu Thr Thr Gln Thr Glu Ile Asn Gly Ala 
                805                 810                 815     


Ile Val Phe Gly Gly Thr Thr Thr Pro Val Pro Lys Ser Ala Thr Thr 
            820                 825                 830         


Gln Arg Leu Asn Ala Thr Val Thr Arg Lys Glu Ala Thr Ser His Tyr 
        835                 840                 845             


Leu Met Arg Lys Ser Thr Ile Ala Ala Val Ala Glu Val Ser Pro Phe 
    850                 855                 860                 


Ser Thr Met Leu Glu Val Thr Asp Glu Ser Ala Gln Arg Val Thr Ala 
865                 870                 875                 880 


Ser Val Thr Val Ser Ser Phe Pro Asp Ile Glu Lys Leu Ser Thr Pro 
                885                 890                 895     


Leu Asp Asn Lys Thr Ala Thr Thr Glu Val Arg Glu Ser Trp Leu Leu 
            900                 905                 910         


Thr Lys Leu Val Lys Thr Thr Pro Arg Ser Ser Tyr Asn Glu Met Thr 
        915                 920                 925             


Glu Met Phe Asn Phe Asn His Thr Tyr Val Ala His Trp Thr Ser Glu 
    930                 935                 940                 


Thr Ser Glu Gly Ile Ser Ala Gly Ser Pro Thr Ser Gly Ser Thr His 
945                 950                 955                 960 


Ile Phe Gly Glu Pro Leu Gly Ala Ser Thr Thr Arg Ile Ser Glu Thr 
                965                 970                 975     


Ser Phe Ser Thr Thr Pro Thr Asp Arg Thr Ala Thr Ser Leu Ser Asp 
            980                 985                 990         


Gly Ile Leu Pro Pro Gln Pro Thr  Ala Ala His Ser Ser  Ala Thr Pro 
        995                 1000                 1005             


Val Pro  Val Thr His Met Phe  Ser Leu Pro Val Asn  Gly Ser Ser 
    1010                 1015                 1020             


Val Val  Ala Glu Glu Thr Glu  Val Thr Met Ser Glu  Pro Ser Thr 
    1025                 1030                 1035             


Leu Ala  Arg Ala Phe Ser Thr  Ser Val Leu Ser Asp  Val Ser Asn 
    1040                 1045                 1050             


Leu Ser  Ser Thr Thr Met Thr  Thr Ala Leu Val Pro  Pro Leu Asp 
    1055                 1060                 1065             


Gln Thr  Ala Ser Thr Thr Ile  Val Ile Val Pro Thr  His Gly Asp 
    1070                 1075                 1080             


Leu Ile  Arg Thr Thr Ser Glu  Ala Thr Val Ile Ser  Val Arg Lys 
    1085                 1090                 1095             


Thr Ser  Met Ala Val Pro Ser  Leu Thr Glu Thr Pro  Phe His Ser 
    1100                 1105                 1110             


Leu Arg  Leu Ser Thr Pro Val  Thr Ala Lys Ala Glu  Thr Thr Leu 
    1115                 1120                 1125             


Phe Ser  Thr Ser Val Asp Thr  Val Thr Pro Ser Thr  His Thr Leu 
    1130                 1135                 1140             


Val Cys  Ser Lys Pro Pro Pro  Asp Asn Ile Pro Pro  Ala Ser Ser 
    1145                 1150                 1155             


Thr His  Val Ile Ser Thr Thr  Ser Thr Pro Glu Ala  Thr Gln Pro 
    1160                 1165                 1170             


Ile Ser  Gln Val Glu Glu Thr  Ser Thr Tyr Ala Leu  Ser Phe Pro 
    1175                 1180                 1185             


Tyr Thr  Phe Ser Gly Gly Gly  Val Val Ala Ser Leu  Ala Thr Gly 
    1190                 1195                 1200             


Thr Thr  Glu Thr Ser Val Val  Asp Glu Thr Thr Pro  Ser His Ile 
    1205                 1210                 1215             


Ser Ala  Asn Lys Leu Thr Thr  Ser Val Asn Ser His  Ile Ser Ser 
    1220                 1225                 1230             


Ser Ala  Thr Tyr Arg Val His  Thr Pro Val Ser Ile  Gln Leu Val 
    1235                 1240                 1245             


Thr Ser  Thr Ser Val Leu Ser  Ser Asp Lys Asp Gln  Met Thr Ile 
    1250                 1255                 1260             


Ser Leu  Gly Lys Thr Pro Arg  Thr Met Glu Val Thr  Glu Met Ser 
    1265                 1270                 1275             


Pro Ser  Lys Asn Ser Phe Ile  Ser Tyr Ser Arg Gly  Thr Pro Ser 
    1280                 1285                 1290             


Leu Glu  Met Thr Asp Thr Gly  Phe Pro Glu Thr Thr  Lys Ile Ser 
    1295                 1300                 1305             


Ser His  Gln Thr His Ser Pro  Ser Glu Ile Pro Leu  Gly Thr Pro 
    1310                 1315                 1320             


Ser Asp  Gly Asn Leu Ala Ser  Ser Pro Thr Ser Gly  Ser Thr Gln 
    1325                 1330                 1335             


Ile Thr  Pro Thr Leu Thr Ser  Ser Asn Thr Val Gly  Val His Ile 
    1340                 1345                 1350             


Pro Glu  Met Ser Thr Ser Leu  Gly Lys Thr Ala Leu  Pro Ser Gln 
    1355                 1360                 1365             


Ala Leu  Thr Ile Thr Thr Phe  Leu Cys Pro Glu Lys  Glu Ser Thr 
    1370                 1375                 1380             


Ser Ala  Leu Pro Ala Tyr Thr  Pro Arg Thr Val Glu  Met Ile Val 
    1385                 1390                 1395             


Asn Ser  Thr Tyr Val Thr His  Ser Val Ser Tyr Gly  Gln Asp Thr 
    1400                 1405                 1410             


Ser Phe  Val Asp Thr Thr Thr  Ser Ser Ser Thr Arg  Ile Ser Asn 
    1415                 1420                 1425             


Pro Met  Asp Ile Asn Thr Thr  Phe Ser His Leu His  Ser Leu Arg 
    1430                 1435                 1440             


Thr Gln  Pro Glu Val Thr Ser  Val Ala Ser Phe Ile  Ser Glu Ser 
    1445                 1450                 1455             


Thr Gln  Thr Phe Pro Glu Ser  Leu Ser Leu Ser Thr  Ala Gly Leu 
    1460                 1465                 1470             


Tyr Asn  Asp Gly Phe Thr Val  Leu Ser Asp Arg Ile  Thr Thr Ala 
    1475                 1480                 1485             


Phe Ser  Val Pro Asn Val Pro  Thr Met Leu Pro Arg  Glu Ser Ser 
    1490                 1495                 1500             


Met Ala  Thr Ser Thr Pro Ile  Tyr Gln Met Ser Ser  Leu Pro Val 
    1505                 1510                 1515             


Asn Val  Thr Ala Phe Thr Ser  Lys Lys Val Ser Asp  Thr Pro Pro 
    1520                 1525                 1530             


Ile Val  Ile Thr Lys Ser Ser  Lys Thr Met His Pro  Gly Cys Leu 
    1535                 1540                 1545             


Lys Ser  Pro Cys Thr Ala Thr  Ser Gly Pro Met Ser  Glu Met Ser 
    1550                 1555                 1560             


Ser Ile  Pro Val Asn Asn Ser  Ala Phe Thr Pro Ala  Thr Val Ser 
    1565                 1570                 1575             


Ser Asp  Thr Ser Thr Arg Val  Gly Leu Phe Ser Thr  Leu Leu Ser 
    1580                 1585                 1590             


Ser Val  Thr Pro Arg Thr Thr  Met Thr Met Gln Thr  Ser Thr Leu 
    1595                 1600                 1605             


Asp Val  Thr Pro Val Ile Tyr  Ala Gly Ala Thr Ser  Lys Asn Lys 
    1610                 1615                 1620             


Met Val  Ser Ser Ala Phe Thr  Thr Glu Met Ile Glu  Ala Pro Ser 
    1625                 1630                 1635             


Arg Ile  Thr Pro Thr Thr Phe  Leu Ser Pro Thr Glu  Pro Thr Leu 
    1640                 1645                 1650             


Pro Phe  Val Lys Thr Val Pro  Thr Thr Ile Met Ala  Gly Ile Val 
    1655                 1660                 1665             


Thr Pro  Phe Val Gly Thr Thr  Ala Phe Ser Pro Leu  Ser Ser Lys 
    1670                 1675                 1680             


Ser Thr  Gly Ala Ile Ser Ser  Ile Pro Lys Thr Thr  Phe Ser Pro 
    1685                 1690                 1695             


Phe Leu  Ser Ala Thr Gln Gln  Ser Ser Gln Ala Asp  Glu Ala Thr 
    1700                 1705                 1710             


Thr Leu  Gly Ile Leu Ser Gly  Ile Thr Asn Arg Ser  Leu Ser Thr 
    1715                 1720                 1725             


Val Asn  Ser Gly Thr Gly Val  Ala Leu Thr Asp Thr  Tyr Ser Arg 
    1730                 1735                 1740             


Ile Thr  Val Pro Glu Asn Met  Leu Ser Pro Thr His  Ala Asp Ser 
    1745                 1750                 1755             


Leu His  Thr Ser Phe Asn Ile  Gln Val Ser Pro Ser  Leu Thr Ser 
    1760                 1765                 1770             


Phe Lys  Ser Ala Ser Gly Pro  Thr Lys Asn Val Lys  Thr Thr Thr 
    1775                 1780                 1785             


Asn Cys  Phe Ser Ser Asn Thr  Arg Lys Met Thr Ser  Leu Leu Glu 
    1790                 1795                 1800             


Lys Thr  Ser Leu Thr Asn Tyr  Ala Thr Ser Leu Asn  Thr Pro Val 
    1805                 1810                 1815             


Ser Tyr  Pro Pro Trp Thr Pro  Ser Ser Ala Thr Leu  Pro Ser Leu 
    1820                 1825                 1830             


Thr Ser  Phe Val Tyr Ser Pro  His Ser Thr Glu Ala  Glu Ile Ser 
    1835                 1840                 1845             


Thr Pro  Lys Thr Ser Pro Pro  Pro Thr Ser Gln Met  Val Glu Phe 
    1850                 1855                 1860             


Pro Val  Leu Gly Thr Arg Met  Thr Ser Ser Asn Thr  Gln Pro Leu 
    1865                 1870                 1875             


Leu Met  Thr Ser Trp Asn Ile  Pro Thr Ala Glu Gly  Ser Gln Phe 
    1880                 1885                 1890             


Pro Ile  Ser Thr Thr Ile Asn  Val Pro Thr Ser Asn  Glu Met Glu 
    1895                 1900                 1905             


Thr Glu  Thr Leu His Leu Val  Pro Gly Pro Leu Ser  Thr Phe Thr 
    1910                 1915                 1920             


Ala Ser  Gln Thr Gly Leu Val  Ser Lys Asp Val Met  Ala Met Ser 
    1925                 1930                 1935             


Ser Ile  Pro Met Ser Gly Ile  Leu Pro Asn His Gly  Leu Ser Glu 
    1940                 1945                 1950             


Asn Pro  Ser Leu Ser Thr Ser  Leu Arg Ala Ile Thr  Ser Thr Leu 
    1955                 1960                 1965             


Ala Asp  Val Lys His Thr Phe  Glu Lys Met Thr Thr  Ser Val Thr 
    1970                 1975                 1980             


Pro Gly  Thr Thr Leu Pro Ser  Ile Leu Ser Gly Ala  Thr Ser Gly 
    1985                 1990                 1995             


Ser Val  Ile Ser Lys Ser Pro  Ile Leu Thr Trp Leu  Leu Ser Ser 
    2000                 2005                 2010             


Leu Pro  Ser Gly Ser Pro Pro  Ala Thr Val Ser Asn  Ala Pro His 
    2015                 2020                 2025             


Val Met  Thr Ser Ser Thr Val  Glu Val Ser Lys Ser  Thr Phe Leu 
    2030                 2035                 2040             


Thr Ser  Asp Met Ile Ser Ala  His Pro Phe Thr Asn  Leu Thr Thr 
    2045                 2050                 2055             


Leu Pro  Ser Ala Thr Met Ser  Thr Ile Leu Thr Arg  Thr Ile Pro 
    2060                 2065                 2070             


Thr Pro  Thr Leu Gly Gly Ile  Thr Thr Gly Phe Pro  Thr Ser Leu 
    2075                 2080                 2085             


Pro Met  Ser Ile Asn Val Thr  Asp Asp Ile Val Tyr  Ile Ser Thr 
    2090                 2095                 2100             


His Pro  Glu Ala Ser Ser Arg  Thr Thr Ile Thr Ala  Asn Pro Arg 
    2105                 2110                 2115             


Thr Val  Ser His Pro Ser Ser  Phe Ser Arg Lys Thr  Met Ser Pro 
    2120                 2125                 2130             


Ser Thr  Thr Asp His Thr Leu  Ser Val Gly Ala Met  Pro Leu Pro 
    2135                 2140                 2145             


Ser Ser  Thr Ile Thr Ser Ser  Trp Asn Arg Ile Pro  Thr Ala Ser 
    2150                 2155                 2160             


Ser Pro  Ser Thr Leu Ile Ile  Pro Lys Pro Thr Leu  Asp Ser Leu 
    2165                 2170                 2175             


Leu Asn  Ile Met Thr Thr Thr  Ser Thr Val Pro Gly  Ala Ser Phe 
    2180                 2185                 2190             


Pro Leu  Ile Ser Thr Gly Val  Thr Tyr Pro Phe Thr  Ala Thr Val 
    2195                 2200                 2205             


Ser Ser  Pro Ile Ser Ser Phe  Phe Glu Thr Thr Trp  Leu Asp Ser 
    2210                 2215                 2220             


Thr Pro  Ser Phe Leu Ser Thr  Glu Ala Ser Thr Ser  Pro Thr Ala 
    2225                 2230                 2235             


Thr Lys  Ser Thr Val Ser Phe  Tyr Asn Val Glu Met  Ser Phe Ser 
    2240                 2245                 2250             


Val Phe  Val Glu Glu Pro Arg  Ile Pro Ile Thr Ser  Val Ile Asn 
    2255                 2260                 2265             


Glu Phe  Thr Glu Asn Ser Leu  Asn Ser Ile Phe Gln  Asn Ser Glu 
    2270                 2275                 2280             


Phe Ser  Leu Ala Thr Leu Glu  Thr Gln Ile Lys Ser  Arg Asp Ile 
    2285                 2290                 2295             


Ser Glu  Glu Glu Met Val Met  Asp Arg Ala Ile Leu  Glu Gln Arg 
    2300                 2305                 2310             


Glu Gly  Gln Glu Met Ala Thr  Ile Ser Tyr Val Pro  Tyr Ser Cys 
    2315                 2320                 2325             


Val Cys  Gln Val Ile Ile Lys  Ala Ser Ser Ser Leu  Ala Ser Ser 
    2330                 2335                 2340             


Glu Leu  Met Arg Lys Ile Lys  Ser Lys Ile His Gly  Asn Phe Thr 
    2345                 2350                 2355             


His Gly  Asn Phe Thr Gln Asp  Gln Leu Thr Leu Leu  Val Asn Cys 
    2360                 2365                 2370             


Glu His  Val Ala Val Lys Lys  Leu Glu Pro Gly Asn  Cys Lys Ala 
    2375                 2380                 2385             


Asp Glu  Thr Ala Ser Lys Tyr  Lys Gly Thr Tyr Lys  Trp Leu Leu 
    2390                 2395                 2400             


Thr Asn  Pro Thr Glu Thr Ala  Gln Thr Arg Cys Ile  Lys Asn Glu 
    2405                 2410                 2415             


Asp Gly  Asn Ala Thr Arg Phe  Cys Ser Ile Ser Ile  Asn Thr Gly 
    2420                 2425                 2430             


Lys Ser  Gln Trp Glu Lys Pro  Lys Phe Lys Gln Cys  Lys Leu Leu 
    2435                 2440                 2445             


Gln Glu  Leu Pro Asp Lys Ile  Val Asp Leu Ala Asn  Ile Thr Ile 
    2450                 2455                 2460             


Ser Asp  Glu Asn Ala Glu Asp  Val Ala Glu His Ile  Leu Asn Leu 
    2465                 2470                 2475             


Ile Asn  Glu Ser Pro Ala Leu  Gly Lys Glu Glu Thr  Lys Ile Ile 
    2480                 2485                 2490             


Val Ser  Lys Ile Ser Asp Ile  Ser Gln Cys Asp Glu  Ile Ser Met 
    2495                 2500                 2505             


Asn Leu  Thr His Val Met Leu  Gln Ile Ile Asn Val  Val Leu Glu 
    2510                 2515                 2520             


Lys Gln  Asn Asn Ser Ala Ser  Asp Leu His Glu Ile  Ser Asn Glu 
    2525                 2530                 2535             


Ile Leu  Arg Ile Ile Glu Arg  Thr Gly His Lys Met  Glu Phe Ser 
    2540                 2545                 2550             


Gly Gln  Ile Ala Asn Leu Thr  Val Ala Gly Leu Ala  Leu Ala Val 
    2555                 2560                 2565             


Leu Arg  Gly Asp His Thr Phe  Asp Gly Met Ala Phe  Ser Ile His 
    2570                 2575                 2580             


Ser Tyr  Glu Glu Gly Thr Asp  Pro Glu Ile Phe Leu  Gly Asn Val 
    2585                 2590                 2595             


Pro Val  Gly Gly Ile Leu Ala  Ser Ile Tyr Leu Pro  Lys Ser Leu 
    2600                 2605                 2610             


Thr Glu  Arg Ile Pro Leu Ser  Asn Leu Gln Thr Ile  Leu Phe Asn 
    2615                 2620                 2625             


Phe Phe  Gly Gln Thr Ser Leu  Phe Lys Thr Lys Asn  Val Thr Lys 
    2630                 2635                 2640             


Ala Leu  Thr Thr Tyr Val Val  Ser Ala Ser Ile Ser  Asp Asp Met 
    2645                 2650                 2655             


Phe Ile  Gln Asn Leu Ala Asp  Pro Val Val Ile Thr  Leu Gln His 
    2660                 2665                 2670             


Ile Gly  Gly Asn Gln Asn Tyr  Gly Gln Val His Cys  Ala Phe Trp 
    2675                 2680                 2685             


Asp Phe  Glu Asn Asn Asn Gly  Leu Gly Gly Trp Asn  Ser Ser Gly 
    2690                 2695                 2700             


Cys Lys  Val Lys Glu Thr Asn  Val Asn Tyr Thr Ile  Cys Gln Cys 
    2705                 2710                 2715             


Asp His  Leu Thr His Phe Gly  Val Leu Met Asp Leu  Ser Arg Ser 
    2720                 2725                 2730             


Thr Val  Asp Ser Val Asn Glu  Gln Ile Leu Ala Leu  Ile Thr Tyr 
    2735                 2740                 2745             


Thr Gly  Cys Gly Ile Ser Ser  Ile Phe Leu Gly Val  Ala Val Val 
    2750                 2755                 2760             


Thr Tyr  Ile Ala Phe His Lys  Leu Arg Lys Asp Tyr  Pro Ala Lys 
    2765                 2770                 2775             


Ile Leu  Ile Asn Leu Cys Thr  Ala Leu Leu Met Leu  Asn Leu Val 
    2780                 2785                 2790             


Phe Leu  Ile Asn Ser Trp Leu  Ser Ser Phe Gln Lys  Val Gly Val 
    2795                 2800                 2805             


Cys Ile  Thr Ala Ala Val Ala  Leu His Tyr Phe Leu  Leu Val Ser 
    2810                 2815                 2820             


Phe Thr  Trp Met Gly Leu Glu  Ala Val His Met Tyr  Leu Ala Leu 
    2825                 2830                 2835             


Val Lys  Val Phe Asn Ile Tyr  Ile Pro Asn Tyr Ile  Leu Lys Phe 
    2840                 2845                 2850             


Cys Leu  Val Gly Trp Gly Ile  Pro Ala Ile Met Val  Ala Ile Thr 
    2855                 2860                 2865             


Val Ser  Val Lys Lys Asp Leu  Tyr Gly Thr Leu Ser  Pro Thr Thr 
    2870                 2875                 2880             


Pro Phe  Cys Trp Ile Lys Asp  Asp Ser Ile Phe Tyr  Ile Ser Val 
    2885                 2890                 2895             


Val Ala  Tyr Phe Cys Leu Ile  Phe Leu Met Asn Leu  Ser Met Phe 
    2900                 2905                 2910             


Cys Thr  Val Leu Val Gln Leu  Asn Ser Val Lys Ser  Gln Ile Gln 
    2915                 2920                 2925             


Lys Thr  Arg Arg Lys Met Ile  Leu His Asp Leu Lys  Gly Thr Met 
    2930                 2935                 2940             


Ser Leu  Thr Phe Leu Leu Gly  Leu Thr Trp Gly Phe  Ala Phe Phe 
    2945                 2950                 2955             


Ala Trp  Gly Pro Met Arg Asn  Phe Phe Leu Tyr Leu  Phe Ala Ile 
    2960                 2965                 2970             


Phe Asn  Thr Leu Gln Gly Phe  Phe Ile Phe Val Phe  His Cys Val 
    2975                 2980                 2985             


Met Lys  Glu Ser Val Arg Glu  Gln Trp Gln Ile His  Leu Cys Cys 
    2990                 2995                 3000             


Gly Trp  Leu Arg Leu Asp Asn  Ser Ser Asp Gly Ser  Ser Arg Cys 
    3005                 3010                 3015             


Gln Ile  Lys Val Gly Tyr Lys  Gln Glu Gly Leu Lys  Lys Ile Phe 
    3020                 3025                 3030             


Glu His  Lys Leu Leu Thr Pro  Ser Leu Lys Ser Thr  Ala Thr Ser 
    3035                 3040                 3045             


Ser Thr  Phe Lys Ser Leu Gly  Ser Ala Gln Gly Thr  Pro Ser Glu 
    3050                 3055                 3060             


Ile Ser  Phe Pro Asn Asp Asp  Phe Asp Lys Asp Pro  Tyr Cys Ser 
    3065                 3070                 3075             


Ser Pro  
    3080 


<210>  6238
<211>  873
<212>  PRT
<213>  Homo sapiens

<400>  6238

Met Thr Thr Arg Lys Leu Ser Ala His Ser Ala Ala Thr Pro Gly Tyr 
1               5                   10                  15      


Lys Ala Val Thr His Lys His His Thr Gly Trp Ala Arg Met Ala Lys 
            20                  25                  30          


Thr Gly Leu Pro Glu Lys Gly Gln Ser Gln Ala Gly Gly Glu Ser Gly 
        35                  40                  45              


Ser Gly Gln Leu Leu Asp Gln Glu Asn Gly Ala Gly Glu Ser Ala Leu 
    50                  55                  60                  


Val Ser Val Tyr Val His Leu Asp Phe Pro Asp Lys Thr Trp Pro Pro 
65                  70                  75                  80  


Glu Leu Ser Arg Thr Leu Thr Leu Pro Ala Ala Ser Ala Ser Ser Ser 
                85                  90                  95      


Pro Arg Pro Leu Leu Thr Gly Leu Arg Leu Thr Thr Gly Glu Tyr Met 
            100                 105                 110         


Ser Cys Phe Glu Ala Gln Gly Phe Lys Trp Asn Leu Tyr Glu Val Val 
        115                 120                 125             


Arg Val Pro Leu Lys Ala Thr Asp Val Ala Arg Leu Pro Tyr Gln Leu 
    130                 135                 140                 


Ser Ile Ser Cys Ala Thr Ser Pro Gly Phe Gln Leu Ser Cys Cys Ile 
145                 150                 155                 160 


Pro Ser Thr Asn Leu Ala Tyr Thr Ala Ala Trp Ser Pro Gly Glu Gly 
                165                 170                 175     


Ser Lys Ala Ser Ser Phe Asn Glu Ser Gly Ser Gln Cys Phe Val Leu 
            180                 185                 190         


Ala Val Gln Arg Cys Pro Met Ala Asp Thr Thr Tyr Ala Cys Asp Leu 
        195                 200                 205             


Gln Ser Leu Gly Leu Ala Pro Leu Arg Val Pro Ile Ser Ile Thr Ile 
    210                 215                 220                 


Ile Gln Asp Gly Asp Ile Thr Cys Pro Glu Asp Ala Ser Val Leu Thr 
225                 230                 235                 240 


Trp Asn Val Thr Lys Ala Gly His Val Ala Gln Ala Pro Cys Pro Glu 
                245                 250                 255     


Ser Lys Arg Gly Ile Val Arg Arg Leu Cys Gly Ala Asp Gly Val Trp 
            260                 265                 270         


Gly Pro Val His Ser Ser Cys Thr Asp Ala Arg Leu Leu Ala Leu Phe 
        275                 280                 285             


Thr Arg Thr Lys Leu Leu Gln Ala Gly Gln Gly Ser Pro Ala Glu Glu 
    290                 295                 300                 


Val Pro Gln Ile Leu Ala Gln Leu Pro Gly Gln Ala Ala Glu Ala Ser 
305                 310                 315                 320 


Ser Pro Ser Asp Leu Leu Thr Leu Leu Ser Thr Met Lys Tyr Val Ala 
                325                 330                 335     


Lys Val Val Ala Glu Ala Arg Ile Gln Leu Asp Arg Arg Ala Leu Lys 
            340                 345                 350         


Asn Leu Leu Ile Ala Thr Asp Lys Val Leu Asp Met Asp Thr Arg Ser 
        355                 360                 365             


Leu Trp Thr Leu Ala Gln Ala Arg Lys Pro Trp Ala Gly Ser Thr Leu 
    370                 375                 380                 


Leu Leu Ala Val Glu Thr Leu Ala Cys Ser Leu Cys Pro Gln Asp His 
385                 390                 395                 400 


Pro Phe Ala Phe Ser Leu Pro Asn Val Leu Leu Gln Ser Gln Leu Phe 
                405                 410                 415     


Gly Pro Thr Phe Pro Ala Asp Tyr Ser Ile Ser Phe Pro Thr Arg Pro 
            420                 425                 430         


Pro Leu Gln Ala Gln Ile Pro Arg His Ser Leu Ala Pro Leu Val Arg 
        435                 440                 445             


Asn Gly Thr Glu Ile Ser Ile Thr Ser Leu Val Leu Arg Lys Leu Asp 
    450                 455                 460                 


His Leu Leu Pro Ser Asn Tyr Gly Gln Gly Leu Gly Asp Ser Leu Tyr 
465                 470                 475                 480 


Ala Thr Pro Gly Leu Val Leu Val Ile Ser Ile Met Ala Gly Asp Arg 
                485                 490                 495     


Ala Phe Ser Gln Gly Glu Val Ile Met Asp Phe Gly Asn Thr Asp Gly 
            500                 505                 510         


Ser Pro His Cys Val Phe Trp Asp His Ser Leu Phe Gln Gly Arg Gly 
        515                 520                 525             


Gly Trp Ser Lys Glu Gly Cys Gln Ala Gln Val Ala Ser Ala Ser Pro 
    530                 535                 540                 


Thr Ala Gln Cys Leu Cys Gln His Leu Thr Ala Phe Ser Val Leu Met 
545                 550                 555                 560 


Ser Pro His Thr Val Pro Glu Glu Pro Ala Leu Ala Leu Leu Thr Gln 
                565                 570                 575     


Val Gly Leu Gly Ala Ser Ile Leu Ala Leu Leu Val Cys Leu Gly Val 
            580                 585                 590         


Tyr Trp Leu Val Trp Arg Val Val Val Arg Asn Lys Ile Ser Tyr Phe 
        595                 600                 605             


Arg His Ala Ala Leu Leu Asn Met Val Phe Cys Leu Leu Ala Ala Asp 
    610                 615                 620                 


Thr Cys Phe Leu Gly Ala Pro Phe Leu Ser Pro Gly Pro Arg Ser Pro 
625                 630                 635                 640 


Leu Cys Leu Ala Ala Ala Phe Leu Cys His Phe Leu Tyr Leu Ala Thr 
                645                 650                 655     


Phe Phe Trp Met Leu Ala Gln Ala Leu Val Leu Ala His Gln Leu Leu 
            660                 665                 670         


Phe Val Phe His Gln Leu Ala Lys His Arg Val Leu Pro Leu Met Val 
        675                 680                 685             


Leu Leu Gly Tyr Leu Cys Pro Leu Gly Leu Ala Gly Val Thr Leu Gly 
    690                 695                 700                 


Leu Tyr Leu Pro Gln Gly Gln Tyr Leu Arg Glu Gly Glu Cys Trp Leu 
705                 710                 715                 720 


Asp Gly Lys Gly Gly Ala Leu Tyr Thr Phe Val Gly Pro Val Leu Ala 
                725                 730                 735     


Ile Ile Gly Val Asn Gly Leu Val Leu Ala Met Ala Met Leu Lys Leu 
            740                 745                 750         


Leu Arg Pro Ser Leu Ser Glu Gly Pro Pro Ala Glu Lys Arg Gln Ala 
        755                 760                 765             


Leu Leu Gly Val Ile Lys Ala Leu Leu Ile Leu Thr Pro Ile Phe Gly 
    770                 775                 780                 


Leu Thr Trp Gly Leu Gly Leu Ala Thr Leu Leu Glu Glu Val Ser Thr 
785                 790                 795                 800 


Val Pro His Tyr Ile Phe Thr Ile Leu Asn Thr Leu Gln Gly Val Phe 
                805                 810                 815     


Ile Leu Leu Phe Gly Cys Leu Met Asp Arg Lys Ile Gln Glu Ala Leu 
            820                 825                 830         


Arg Lys Arg Phe Cys Arg Ala Gln Ala Pro Ser Ser Thr Ile Ser Leu 
        835                 840                 845             


Ala Thr Asn Glu Gly Cys Ile Leu Glu His Ser Lys Gly Gly Ser Asp 
    850                 855                 860                 


Thr Ala Arg Lys Thr Asp Ala Ser Glu 
865                 870             


<210>  6239
<211>  528
<212>  PRT
<213>  Homo sapiens

<400>  6239

Met Asp His Cys Gly Ala Leu Phe Leu Cys Leu Cys Leu Leu Thr Leu 
1               5                   10                  15      


Gln Asn Ala Thr Thr Glu Thr Trp Glu Glu Leu Leu Ser Tyr Met Glu 
            20                  25                  30          


Asn Met Gln Val Ser Arg Gly Arg Ser Ser Val Phe Ser Ser Arg Gln 
        35                  40                  45              


Leu His Gln Leu Glu Gln Met Leu Leu Asn Thr Ser Phe Pro Gly Tyr 
    50                  55                  60                  


Asn Leu Thr Leu Gln Thr Pro Thr Ile Gln Ser Leu Ala Phe Lys Leu 
65                  70                  75                  80  


Ser Cys Asp Phe Ser Gly Leu Ser Leu Thr Ser Ala Thr Leu Lys Arg 
                85                  90                  95      


Val Pro Gln Ala Gly Gly Gln His Ala Arg Gly Gln His Ala Met Gln 
            100                 105                 110         


Phe Pro Ala Glu Leu Thr Arg Asp Ala Cys Lys Thr Arg Pro Arg Glu 
        115                 120                 125             


Leu Arg Leu Ile Cys Ile Tyr Phe Ser Asn Thr His Phe Phe Lys Asp 
    130                 135                 140                 


Glu Asn Asn Ser Ser Leu Leu Asn Asn Tyr Val Leu Gly Ala Gln Leu 
145                 150                 155                 160 


Ser His Gly His Val Asn Asn Leu Arg Asp Pro Val Asn Ile Ser Phe 
                165                 170                 175     


Trp His Asn Gln Ser Leu Glu Gly Tyr Thr Leu Thr Cys Val Phe Trp 
            180                 185                 190         


Lys Glu Gly Ala Arg Lys Gln Pro Trp Gly Gly Trp Ser Pro Glu Gly 
        195                 200                 205             


Cys Arg Thr Glu Gln Pro Ser His Ser Gln Val Leu Cys Arg Cys Asn 
    210                 215                 220                 


His Leu Thr Tyr Phe Ala Val Leu Met Gln Leu Ser Pro Ala Leu Val 
225                 230                 235                 240 


Pro Ala Glu Leu Leu Ala Pro Leu Thr Tyr Ile Ser Leu Val Gly Cys 
                245                 250                 255     


Ser Ile Ser Ile Val Ala Ser Leu Ile Thr Val Leu Leu His Phe His 
            260                 265                 270         


Phe Arg Lys Gln Ser Asp Ser Leu Thr Arg Ile His Met Asn Leu His 
        275                 280                 285             


Ala Ser Val Leu Leu Leu Asn Ile Ala Phe Leu Leu Ser Pro Ala Phe 
    290                 295                 300                 


Ala Met Ser Pro Val Pro Gly Ser Ala Cys Thr Ala Leu Ala Ala Ala 
305                 310                 315                 320 


Leu His Tyr Ala Leu Leu Ser Cys Leu Thr Trp Met Ala Ile Glu Gly 
                325                 330                 335     


Phe Asn Leu Tyr Leu Leu Leu Gly Arg Val Tyr Asn Ile Tyr Ile Arg 
            340                 345                 350         


Arg Tyr Val Phe Lys Leu Gly Val Leu Gly Trp Gly Ala Pro Ala Leu 
        355                 360                 365             


Leu Val Leu Leu Ser Leu Ser Val Lys Ser Ser Val Tyr Gly Pro Cys 
    370                 375                 380                 


Thr Ile Pro Val Phe Asp Ser Trp Glu Asn Gly Thr Gly Phe Gln Asn 
385                 390                 395                 400 


Met Ser Ile Cys Trp Val Arg Ser Pro Val Val His Ser Val Leu Val 
                405                 410                 415     


Met Gly Tyr Gly Gly Leu Thr Ser Leu Phe Asn Leu Val Val Leu Ala 
            420                 425                 430         


Trp Ala Leu Trp Thr Leu Arg Arg Leu Arg Glu Arg Ala Asp Ala Pro 
        435                 440                 445             


Ser Val Arg Ala Cys His Asp Thr Val Thr Val Leu Gly Leu Thr Val 
    450                 455                 460                 


Leu Leu Gly Thr Thr Trp Ala Leu Ala Phe Phe Ser Phe Gly Val Phe 
465                 470                 475                 480 


Leu Leu Pro Gln Leu Phe Leu Phe Thr Ile Leu Asn Ser Leu Tyr Gly 
                485                 490                 495     


Phe Phe Leu Phe Leu Trp Phe Cys Ser Gln Arg Cys Arg Ser Glu Ala 
            500                 505                 510         


Glu Ala Lys Ala Gln Ile Glu Ala Phe Ser Ser Ser Gln Thr Thr Gln 
        515                 520                 525             


<210>  6240
<211>  695
<212>  PRT
<213>  Homo sapiens

<400>  6240

Met Lys Met Lys Ser Gln Ala Thr Met Ile Cys Cys Leu Val Phe Phe 
1               5                   10                  15      


Leu Ser Thr Glu Cys Ser His Tyr Arg Ser Lys Ile His Leu Lys Ala 
            20                  25                  30          


Gly Asp Lys Leu Gln Ser Pro Glu Gly Lys Pro Lys Thr Gly Arg Ile 
        35                  40                  45              


Gln Glu Lys Cys Glu Gly Pro Cys Ile Ser Ser Ser Asn Cys Ser Gln 
    50                  55                  60                  


Pro Cys Ala Lys Asp Phe His Gly Glu Ile Gly Phe Thr Cys Asn Gln 
65                  70                  75                  80  


Lys Lys Trp Gln Lys Ser Ala Glu Thr Cys Thr Ser Leu Ser Val Glu 
                85                  90                  95      


Lys Leu Phe Lys Asp Ser Thr Gly Ala Ser Arg Leu Ser Val Ala Ala 
            100                 105                 110         


Pro Ser Ile Pro Leu His Ile Leu Asp Phe Arg Ala Pro Glu Thr Ile 
        115                 120                 125             


Glu Ser Val Ala Gln Gly Ile Arg Lys Asn Cys Pro Phe Asp Tyr Ala 
    130                 135                 140                 


Cys Ile Thr Asp Met Val Lys Ser Ser Glu Thr Thr Ser Gly Asn Ile 
145                 150                 155                 160 


Ala Phe Ile Val Glu Leu Leu Lys Asn Ile Ser Thr Asp Leu Ser Asp 
                165                 170                 175     


Asn Val Thr Arg Glu Lys Met Lys Ser Tyr Ser Glu Val Ala Asn His 
            180                 185                 190         


Ile Leu Asp Thr Ala Ala Ile Ser Asn Trp Ala Phe Ile Pro Asn Lys 
        195                 200                 205             


Asn Ala Ser Ser Asp Leu Leu Gln Ser Val Asn Leu Phe Ala Arg Gln 
    210                 215                 220                 


Leu His Ile His Asn Asn Ser Glu Asn Ile Val Asn Glu Leu Phe Ile 
225                 230                 235                 240 


Gln Thr Lys Gly Phe His Ile Asn His Asn Thr Ser Glu Lys Ser Leu 
                245                 250                 255     


Asn Phe Ser Met Ser Met Asn Asn Thr Thr Glu Asp Ile Leu Gly Met 
            260                 265                 270         


Val Gln Ile Pro Arg Gln Glu Leu Arg Lys Leu Trp Pro Asn Ala Ser 
        275                 280                 285             


Gln Ala Ile Ser Ile Ala Phe Pro Thr Leu Gly Ala Ile Leu Arg Glu 
    290                 295                 300                 


Ala His Leu Gln Asn Val Ser Leu Pro Arg Gln Val Asn Gly Leu Val 
305                 310                 315                 320 


Leu Ser Val Val Leu Pro Glu Arg Leu Gln Glu Ile Ile Leu Thr Phe 
                325                 330                 335     


Glu Lys Ile Asn Lys Thr Arg Asn Ala Arg Ala Gln Cys Val Gly Trp 
            340                 345                 350         


His Ser Lys Lys Arg Arg Trp Asp Glu Lys Ala Cys Gln Met Met Leu 
        355                 360                 365             


Asp Ile Arg Asn Glu Val Lys Cys Arg Cys Asn Tyr Thr Ser Val Val 
    370                 375                 380                 


Met Ser Phe Ser Ile Leu Met Ser Ser Lys Ser Met Thr Asp Lys Val 
385                 390                 395                 400 


Leu Asp Tyr Ile Thr Cys Ile Gly Leu Ser Val Ser Ile Leu Ser Leu 
                405                 410                 415     


Val Leu Cys Leu Ile Ile Glu Ala Thr Val Trp Ser Arg Val Val Val 
            420                 425                 430         


Thr Glu Ile Ser Tyr Met Arg His Val Cys Ile Val Asn Ile Ala Val 
        435                 440                 445             


Ser Leu Leu Thr Ala Asn Val Trp Phe Ile Ile Gly Ser His Phe Asn 
    450                 455                 460                 


Ile Lys Ala Gln Asp Tyr Asn Met Cys Val Ala Val Thr Phe Phe Ser 
465                 470                 475                 480 


His Phe Phe Tyr Leu Ser Leu Phe Phe Trp Met Leu Phe Lys Ala Leu 
                485                 490                 495     


Leu Ile Ile Tyr Gly Ile Leu Val Ile Phe Arg Arg Met Met Lys Ser 
            500                 505                 510         


Arg Met Met Val Ile Gly Phe Ala Ile Gly Tyr Gly Cys Pro Leu Ile 
        515                 520                 525             


Ile Ala Val Thr Thr Val Ala Ile Thr Glu Pro Glu Lys Gly Tyr Met 
    530                 535                 540                 


Arg Pro Glu Ala Cys Trp Leu Asn Trp Asp Asn Thr Lys Ala Leu Leu 
545                 550                 555                 560 


Ala Phe Ala Ile Pro Ala Phe Val Ile Val Ala Val Asn Leu Ile Val 
                565                 570                 575     


Val Leu Val Val Ala Val Asn Thr Gln Arg Pro Ser Ile Gly Ser Ser 
            580                 585                 590         


Lys Ser Gln Asp Val Val Ile Ile Met Arg Ile Ser Lys Asn Val Ala 
        595                 600                 605             


Ile Leu Thr Pro Leu Leu Gly Leu Thr Trp Gly Phe Gly Ile Ala Thr 
    610                 615                 620                 


Leu Ile Glu Gly Thr Ser Leu Thr Phe His Ile Ile Phe Ala Leu Leu 
625                 630                 635                 640 


Asn Ala Phe Gln Gly Phe Phe Ile Leu Leu Phe Gly Thr Ile Met Asp 
                645                 650                 655     


His Lys Ile Arg Asp Ala Leu Arg Met Arg Met Ser Ser Leu Lys Gly 
            660                 665                 670         


Lys Ser Arg Ala Ala Glu Asn Ala Ser Leu Gly Pro Thr Asn Gly Ser 
        675                 680                 685             


Lys Leu Met Asn Arg Gln Gly 
    690                 695 


<210>  6241
<211>  642
<212>  PRT
<213>  Homo sapiens

<400>  6241

Met Thr His Ile Leu Leu Leu Tyr Tyr Leu Val Phe Leu Leu Pro Thr 
1               5                   10                  15      


Glu Ser Cys Arg Thr Leu Tyr Gln Ala Ala Ser Lys Ser Lys Glu Lys 
            20                  25                  30          


Val Pro Ala Arg Pro His Gly Val Cys Asp Gly Val Cys Thr Asp Tyr 
        35                  40                  45              


Ser Gln Cys Thr Gln Pro Cys Pro Pro Asp Thr Gln Gly Asn Met Gly 
    50                  55                  60                  


Phe Ser Cys Arg Gln Lys Thr Trp His Lys Ile Thr Asp Thr Cys Gln 
65                  70                  75                  80  


Thr Leu Asn Ala Leu Asn Ile Phe Glu Glu Asp Ser Arg Leu Val Gln 
                85                  90                  95      


Pro Phe Glu Asp Asn Ile Lys Ile Ser Val Tyr Thr Gly Lys Ser Glu 
            100                 105                 110         


Thr Ile Thr Asp Met Leu Leu Gln Lys Cys Pro Thr Asp Leu Ser Cys 
        115                 120                 125             


Val Ile Arg Asn Ile Gln Gln Ser Pro Trp Ile Pro Gly Asn Ile Ala 
    130                 135                 140                 


Val Ile Val Gln Leu Leu His Asn Ile Ser Thr Ala Ile Trp Thr Gly 
145                 150                 155                 160 


Val Asp Glu Ala Lys Met Gln Ser Tyr Ser Thr Ile Ala Asn His Ile 
                165                 170                 175     


Leu Asn Ser Lys Ser Ile Ser Asn Trp Thr Phe Ile Pro Asp Arg Asn 
            180                 185                 190         


Ser Ser Tyr Ile Leu Leu His Ser Val Asn Ser Phe Ala Arg Arg Leu 
        195                 200                 205             


Phe Ile Asp Lys His Pro Val Asp Ile Ser Asp Val Phe Ile His Thr 
    210                 215                 220                 


Met Gly Thr Thr Ile Ser Gly Asp Asn Ile Gly Lys Asn Phe Thr Phe 
225                 230                 235                 240 


Ser Met Arg Ile Asn Asp Thr Ser Asn Glu Val Thr Gly Arg Val Leu 
                245                 250                 255     


Ile Ser Arg Asp Glu Leu Arg Lys Val Pro Ser Pro Ser Gln Val Ile 
            260                 265                 270         


Ser Ile Ala Phe Pro Thr Ile Gly Ala Ile Leu Glu Ala Ser Leu Leu 
        275                 280                 285             


Glu Asn Val Thr Val Asn Gly Leu Val Leu Ser Ala Ile Leu Pro Lys 
    290                 295                 300                 


Glu Leu Lys Arg Ile Ser Leu Ile Phe Glu Lys Ile Ser Lys Ser Glu 
305                 310                 315                 320 


Glu Arg Arg Thr Gln Cys Val Gly Trp His Ser Val Glu Asn Arg Trp 
                325                 330                 335     


Asp Gln Gln Ala Cys Lys Met Ile Gln Glu Asn Ser Gln Gln Ala Val 
            340                 345                 350         


Cys Lys Cys Arg Pro Ser Lys Leu Phe Thr Ser Phe Ser Ile Leu Met 
        355                 360                 365             


Ser Pro His Ile Leu Glu Ser Leu Ile Leu Thr Tyr Ile Thr Tyr Val 
    370                 375                 380                 


Gly Leu Gly Ile Ser Ile Cys Ser Leu Ile Leu Cys Leu Ser Ile Glu 
385                 390                 395                 400 


Val Leu Val Trp Ser Gln Val Thr Lys Thr Glu Ile Thr Tyr Leu Arg 
                405                 410                 415     


His Val Cys Ile Val Asn Ile Ala Ala Thr Leu Leu Met Ala Asp Val 
            420                 425                 430         


Trp Phe Ile Val Ala Ser Phe Leu Ser Gly Pro Ile Thr His His Lys 
        435                 440                 445             


Gly Cys Val Ala Ala Thr Phe Phe Val His Phe Phe Tyr Leu Ser Val 
    450                 455                 460                 


Phe Phe Trp Met Leu Ala Lys Ala Leu Leu Ile Leu Tyr Gly Ile Met 
465                 470                 475                 480 


Ile Val Phe His Thr Leu Pro Lys Ser Val Leu Val Ala Ser Leu Phe 
                485                 490                 495     


Ser Val Gly Tyr Gly Cys Pro Leu Ala Ile Ala Ala Ile Thr Val Ala 
            500                 505                 510         


Ala Thr Glu Pro Gly Lys Gly Tyr Leu Arg Pro Glu Ile Cys Trp Leu 
        515                 520                 525             


Asn Trp Asp Met Thr Lys Ala Leu Leu Ala Phe Val Ile Pro Ala Leu 
    530                 535                 540                 


Ala Ile Val Val Val Asn Leu Ile Thr Val Thr Leu Val Ile Val Lys 
545                 550                 555                 560 


Thr Gln Arg Ala Ala Ile Gly Asn Ser Met Phe Gln Glu Val Arg Ala 
                565                 570                 575     


Ile Val Arg Ile Ser Lys Asn Ile Ala Ile Leu Thr Pro Leu Leu Gly 
            580                 585                 590         


Leu Thr Trp Gly Phe Gly Val Ala Thr Val Ile Asp Asp Arg Ser Leu 
        595                 600                 605             


Ala Phe His Ile Ile Phe Ser Leu Leu Asn Ala Phe Gln Gly Phe Phe 
    610                 615                 620                 


Ile Leu Val Phe Gly Thr Ile Leu Asp Pro Lys Ile Arg Glu Ala Leu 
625                 630                 635                 640 


Lys Gly 
        


<210>  6242
<211>  910
<212>  PRT
<213>  Homo sapiens

<400>  6242

Met Lys Val Gly Val Leu Trp Leu Ile Ser Phe Phe Thr Phe Thr Asp 
1               5                   10                  15      


Gly His Gly Gly Phe Leu Gly Lys Asn Asp Gly Ile Lys Thr Lys Lys 
            20                  25                  30          


Glu Leu Ile Val Asn Lys Lys Lys His Leu Gly Pro Val Glu Glu Tyr 
        35                  40                  45              


Gln Leu Leu Leu Gln Val Thr Tyr Arg Asp Ser Lys Glu Lys Arg Asp 
    50                  55                  60                  


Leu Arg Asn Phe Leu Lys Leu Leu Lys Pro Pro Leu Leu Trp Ser His 
65                  70                  75                  80  


Gly Leu Ile Arg Ile Ile Arg Ala Lys Ala Thr Thr Asp Cys Asn Ser 
                85                  90                  95      


Leu Asn Gly Val Leu Gln Cys Thr Cys Glu Asp Ser Tyr Thr Trp Phe 
            100                 105                 110         


Pro Pro Ser Cys Leu Asp Pro Gln Asn Cys Tyr Leu His Thr Ala Gly 
        115                 120                 125             


Ala Leu Pro Ser Cys Glu Cys His Leu Asn Asn Leu Ser Gln Ser Val 
    130                 135                 140                 


Asn Phe Cys Glu Arg Thr Lys Ile Trp Gly Thr Phe Lys Ile Asn Glu 
145                 150                 155                 160 


Arg Phe Thr Asn Asp Leu Leu Asn Ser Ser Ser Ala Ile Tyr Ser Lys 
                165                 170                 175     


Tyr Ala Asn Gly Ile Glu Ile Gln Leu Lys Lys Ala Tyr Glu Arg Ile 
            180                 185                 190         


Gln Gly Phe Glu Ser Val Gln Val Thr Gln Phe Arg Asn Gly Ser Ile 
        195                 200                 205             


Val Ala Gly Tyr Glu Val Val Gly Ser Ser Ser Ala Ser Glu Leu Leu 
    210                 215                 220                 


Ser Ala Ile Glu His Val Ala Glu Lys Ala Lys Thr Ala Leu His Lys 
225                 230                 235                 240 


Leu Phe Pro Leu Glu Asp Gly Ser Phe Arg Val Phe Gly Lys Ala Gln 
                245                 250                 255     


Cys Asn Asp Ile Val Phe Gly Phe Gly Ser Lys Asp Asp Glu Tyr Thr 
            260                 265                 270         


Leu Pro Cys Ser Ser Gly Tyr Arg Gly Asn Ile Thr Ala Lys Cys Glu 
        275                 280                 285             


Ser Ser Gly Trp Gln Val Ile Arg Glu Thr Cys Val Leu Ser Leu Leu 
    290                 295                 300                 


Glu Glu Leu Asn Lys Asn Phe Ser Met Ile Val Gly Asn Ala Thr Glu 
305                 310                 315                 320 


Ala Ala Val Ser Ser Phe Val Gln Asn Leu Ser Val Ile Ile Arg Gln 
                325                 330                 335     


Asn Pro Ser Thr Thr Val Gly Asn Leu Ala Ser Val Val Ser Ile Leu 
            340                 345                 350         


Ser Asn Ile Ser Ser Leu Ser Leu Ala Ser His Phe Arg Val Ser Asn 
        355                 360                 365             


Ser Thr Met Glu Asp Val Ile Ser Ile Ala Asp Asn Ile Leu Asn Ser 
    370                 375                 380                 


Ala Ser Val Thr Asn Trp Thr Val Leu Leu Arg Glu Glu Lys Tyr Ala 
385                 390                 395                 400 


Ser Ser Arg Leu Leu Glu Thr Leu Glu Asn Ile Ser Thr Leu Val Pro 
                405                 410                 415     


Pro Thr Ala Leu Pro Leu Asn Phe Ser Arg Lys Phe Ile Asp Trp Lys 
            420                 425                 430         


Gly Ile Pro Val Asn Lys Ser Gln Leu Lys Arg Gly Tyr Ser Tyr Gln 
        435                 440                 445             


Ile Lys Met Cys Pro Gln Asn Thr Ser Ile Pro Ile Arg Gly Arg Val 
    450                 455                 460                 


Leu Ile Gly Ser Asp Gln Phe Gln Arg Ser Leu Pro Glu Thr Ile Ile 
465                 470                 475                 480 


Ser Met Ala Ser Leu Thr Leu Gly Asn Ile Leu Pro Val Ser Lys Asn 
                485                 490                 495     


Gly Asn Ala Gln Val Asn Gly Pro Val Ile Ser Thr Val Ile Gln Asn 
            500                 505                 510         


Tyr Ser Ile Asn Glu Val Phe Leu Phe Phe Ser Lys Ile Glu Ser Asn 
        515                 520                 525             


Leu Ser Gln Pro His Cys Val Phe Trp Asp Phe Ser His Leu Gln Trp 
    530                 535                 540                 


Asn Asp Ala Gly Cys His Leu Val Asn Glu Thr Gln Asp Ile Val Thr 
545                 550                 555                 560 


Cys Gln Cys Thr His Leu Thr Ser Phe Ser Ile Leu Met Ser Pro Phe 
                565                 570                 575     


Val Pro Ser Thr Ile Phe Pro Val Val Lys Trp Ile Thr Tyr Val Gly 
            580                 585                 590         


Leu Gly Ile Ser Ile Gly Ser Leu Ile Leu Cys Leu Ile Ile Glu Ala 
        595                 600                 605             


Leu Phe Trp Lys Gln Ile Lys Lys Ser Gln Thr Ser His Thr Arg Arg 
    610                 615                 620                 


Ile Cys Met Val Asn Ile Ala Leu Ser Leu Leu Ile Ala Asp Val Trp 
625                 630                 635                 640 


Phe Ile Val Gly Ala Thr Val Asp Thr Thr Val Asn Pro Ser Gly Val 
                645                 650                 655     


Cys Thr Ala Ala Val Phe Phe Thr His Phe Phe Tyr Leu Ser Leu Phe 
            660                 665                 670         


Phe Trp Met Leu Met Leu Gly Ile Leu Leu Ala Tyr Arg Ile Ile Leu 
        675                 680                 685             


Val Phe His His Met Ala Gln His Leu Met Met Ala Val Gly Phe Cys 
    690                 695                 700                 


Leu Gly Tyr Gly Cys Pro Leu Ile Ile Ser Val Ile Thr Ile Ala Val 
705                 710                 715                 720 


Thr Gln Pro Ser Asn Thr Tyr Lys Arg Lys Asp Val Cys Trp Leu Asn 
                725                 730                 735     


Trp Ser Asn Gly Ser Lys Pro Leu Leu Ala Phe Val Val Pro Ala Leu 
            740                 745                 750         


Ala Ile Val Ala Val Asn Phe Val Val Val Leu Leu Val Leu Thr Lys 
        755                 760                 765             


Leu Trp Arg Pro Thr Val Gly Glu Arg Leu Ser Arg Asp Asp Lys Ala 
    770                 775                 780                 


Thr Ile Ile Arg Val Gly Lys Ser Leu Leu Ile Leu Thr Pro Leu Leu 
785                 790                 795                 800 


Gly Leu Thr Trp Gly Phe Gly Ile Gly Thr Ile Val Asp Ser Gln Asn 
                805                 810                 815     


Leu Ala Trp His Val Ile Phe Ala Leu Leu Asn Ala Phe Gln Gly Phe 
            820                 825                 830         


Phe Ile Leu Cys Phe Gly Ile Leu Leu Asp Ser Lys Leu Arg Gln Leu 
        835                 840                 845             


Leu Phe Asn Lys Leu Ser Ala Leu Ser Ser Trp Lys Gln Thr Glu Lys 
    850                 855                 860                 


Gln Asn Ser Ser Asp Leu Ser Ala Lys Pro Lys Phe Ser Lys Pro Phe 
865                 870                 875                 880 


Asn Pro Leu Gln Asn Lys Gly His Tyr Ala Phe Ser His Thr Gly Asp 
                885                 890                 895     


Ser Ser Asp Asn Ile Met Leu Thr Gln Phe Val Ser Asn Glu 
            900                 905                 910 


<210>  6243
<211>  863
<212>  PRT
<213>  Homo sapiens

<400>  6243

Met Ala Arg Leu Gly Asn Cys Ser Leu Thr Trp Ala Ala Leu Ile Ile 
1               5                   10                  15      


Leu Leu Leu Pro Gly Ser Leu Glu Glu Cys Gly His Ile Ser Val Ser 
            20                  25                  30          


Ala Pro Ile Val His Leu Gly Asp Pro Ile Thr Ala Ser Cys Ile Ile 
        35                  40                  45              


Lys Gln Asn Cys Ser His Leu Asp Pro Glu Pro Gln Ile Leu Trp Arg 
    50                  55                  60                  


Leu Gly Ala Glu Leu Gln Pro Gly Gly Arg Gln Gln Arg Leu Ser Asp 
65                  70                  75                  80  


Gly Thr Gln Glu Ser Ile Ile Thr Leu Pro His Leu Asn His Thr Gln 
                85                  90                  95      


Ala Phe Leu Ser Cys Cys Leu Asn Trp Gly Asn Ser Leu Gln Ile Leu 
            100                 105                 110         


Asp Gln Val Glu Leu Arg Ala Gly Tyr Pro Pro Ala Ile Pro His Asn 
        115                 120                 125             


Leu Ser Cys Leu Met Asn Leu Thr Thr Ser Ser Leu Ile Cys Gln Trp 
    130                 135                 140                 


Glu Pro Gly Pro Glu Thr His Leu Pro Thr Ser Phe Thr Leu Lys Ser 
145                 150                 155                 160 


Phe Lys Ser Arg Gly Asn Cys Gln Thr Gln Gly Asp Ser Ile Leu Asp 
                165                 170                 175     


Cys Val Pro Lys Asp Gly Gln Ser His Cys Cys Ile Pro Arg Lys His 
            180                 185                 190         


Leu Leu Leu Tyr Gln Asn Met Gly Ile Trp Val Gln Ala Glu Asn Ala 
        195                 200                 205             


Leu Gly Thr Ser Met Ser Pro Gln Leu Cys Leu Asp Pro Met Asp Val 
    210                 215                 220                 


Val Lys Leu Glu Pro Pro Met Leu Arg Thr Met Asp Pro Ser Pro Glu 
225                 230                 235                 240 


Ala Ala Pro Pro Gln Ala Gly Cys Leu Gln Leu Cys Trp Glu Pro Trp 
                245                 250                 255     


Gln Pro Gly Leu His Ile Asn Gln Lys Cys Glu Leu Arg His Lys Pro 
            260                 265                 270         


Gln Arg Gly Glu Ala Ser Trp Ala Leu Val Gly Pro Leu Pro Leu Glu 
        275                 280                 285             


Ala Leu Gln Tyr Glu Leu Cys Gly Leu Leu Pro Ala Thr Ala Tyr Thr 
    290                 295                 300                 


Leu Gln Ile Arg Cys Ile Arg Trp Pro Leu Pro Gly His Trp Ser Asp 
305                 310                 315                 320 


Trp Ser Pro Ser Leu Glu Leu Arg Thr Thr Glu Arg Ala Pro Thr Val 
                325                 330                 335     


Arg Leu Asp Thr Trp Trp Arg Gln Arg Gln Leu Asp Pro Arg Thr Val 
            340                 345                 350         


Gln Leu Phe Trp Lys Pro Val Pro Leu Glu Glu Asp Ser Gly Arg Ile 
        355                 360                 365             


Gln Gly Tyr Val Val Ser Trp Arg Pro Ser Gly Gln Ala Gly Ala Ile 
    370                 375                 380                 


Leu Pro Leu Cys Asn Thr Thr Glu Leu Ser Cys Thr Phe His Leu Pro 
385                 390                 395                 400 


Ser Glu Ala Gln Glu Val Ala Leu Val Ala Tyr Asn Ser Ala Gly Thr 
                405                 410                 415     


Ser Arg Pro Thr Pro Val Val Phe Ser Glu Ser Arg Gly Pro Ala Leu 
            420                 425                 430         


Thr Arg Leu His Ala Met Ala Arg Asp Pro His Ser Leu Trp Val Gly 
        435                 440                 445             


Trp Glu Pro Pro Asn Pro Trp Pro Gln Gly Tyr Val Ile Glu Trp Gly 
    450                 455                 460                 


Leu Gly Pro Pro Ser Ala Ser Asn Ser Asn Lys Thr Trp Arg Met Glu 
465                 470                 475                 480 


Gln Asn Gly Arg Ala Thr Gly Phe Leu Leu Lys Glu Asn Ile Arg Pro 
                485                 490                 495     


Phe Gln Leu Tyr Glu Ile Ile Val Thr Pro Leu Tyr Gln Asp Thr Met 
            500                 505                 510         


Gly Pro Ser Gln His Val Tyr Ala Tyr Ser Gln Glu Met Ala Pro Ser 
        515                 520                 525             


His Ala Pro Glu Leu His Leu Lys His Ile Gly Lys Thr Trp Ala Gln 
    530                 535                 540                 


Leu Glu Trp Val Pro Glu Pro Pro Glu Leu Gly Lys Ser Pro Leu Thr 
545                 550                 555                 560 


His Tyr Thr Ile Phe Trp Thr Asn Ala Gln Asn Gln Ser Phe Ser Ala 
                565                 570                 575     


Ile Leu Asn Ala Ser Ser Arg Gly Phe Val Leu His Gly Leu Glu Pro 
            580                 585                 590         


Ala Ser Leu Tyr His Ile His Leu Met Ala Ala Ser Gln Ala Gly Ala 
        595                 600                 605             


Thr Asn Ser Thr Val Leu Thr Leu Met Thr Leu Thr Pro Glu Gly Ser 
    610                 615                 620                 


Glu Leu His Ile Ile Leu Gly Leu Phe Gly Leu Leu Leu Leu Leu Thr 
625                 630                 635                 640 


Cys Leu Cys Gly Thr Ala Trp Leu Cys Cys Ser Pro Asn Arg Lys Asn 
                645                 650                 655     


Pro Leu Trp Pro Ser Val Pro Asp Pro Ala His Ser Ser Leu Gly Ser 
            660                 665                 670         


Trp Val Pro Thr Ile Met Glu Glu Leu Pro Gly Pro Arg Gln Gly Gln 
        675                 680                 685             


Trp Leu Gly Gln Thr Ser Glu Met Ser Arg Ala Leu Thr Pro His Pro 
    690                 695                 700                 


Cys Val Gln Asp Ala Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile 
705                 710                 715                 720 


Thr Lys Leu Thr Val Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp 
                725                 730                 735     


Glu Ser His Asn Ser Ser Glu Thr Cys Gly Leu Pro Thr Leu Val Gln 
            740                 745                 750         


Thr Tyr Val Leu Gln Gly Asp Pro Arg Ala Val Ser Thr Gln Pro Gln 
        755                 760                 765             


Ser Gln Ser Gly Thr Ser Asp Gln Val Leu Tyr Gly Gln Leu Leu Gly 
    770                 775                 780                 


Ser Pro Thr Ser Pro Gly Pro Gly His Tyr Leu Arg Cys Asp Ser Thr 
785                 790                 795                 800 


Gln Pro Leu Leu Ala Gly Leu Thr Pro Ser Pro Lys Ser Tyr Glu Asn 
                805                 810                 815     


Leu Trp Phe Gln Ala Ser Pro Leu Gly Thr Leu Val Thr Pro Ala Pro 
            820                 825                 830         


Ser Gln Glu Asp Asp Cys Val Phe Gly Pro Leu Leu Asn Phe Pro Leu 
        835                 840                 845             


Leu Gln Gly Ile Arg Val His Gly Met Glu Ala Leu Gly Ser Phe 
    850                 855                 860             


<210>  6244
<211>  863
<212>  PRT
<213>  Homo sapiens

<400>  6244

Met Ala Arg Leu Gly Asn Cys Ser Leu Thr Trp Ala Ala Leu Ile Ile 
1               5                   10                  15      


Leu Leu Leu Pro Gly Ser Leu Glu Glu Cys Gly His Ile Ser Val Ser 
            20                  25                  30          


Ala Pro Ile Val His Leu Gly Asp Pro Ile Thr Ala Ser Cys Ile Ile 
        35                  40                  45              


Lys Gln Asn Cys Ser His Leu Asp Pro Glu Pro Gln Ile Leu Trp Arg 
    50                  55                  60                  


Leu Gly Ala Glu Leu Gln Pro Gly Gly Arg Gln Gln Arg Leu Ser Asp 
65                  70                  75                  80  


Gly Thr Gln Glu Ser Ile Ile Thr Leu Pro His Leu Asn His Thr Gln 
                85                  90                  95      


Ala Phe Leu Ser Cys Cys Leu Asn Trp Gly Asn Ser Leu Gln Ile Leu 
            100                 105                 110         


Asp Gln Val Glu Leu Arg Ala Gly Tyr Pro Pro Ala Ile Pro His Asn 
        115                 120                 125             


Leu Ser Cys Leu Met Asn Leu Thr Thr Ser Ser Leu Ile Cys Gln Trp 
    130                 135                 140                 


Glu Pro Gly Pro Glu Thr His Leu Pro Thr Ser Phe Thr Leu Lys Ser 
145                 150                 155                 160 


Phe Lys Ser Arg Gly Asn Cys Gln Thr Gln Gly Asp Ser Ile Leu Asp 
                165                 170                 175     


Cys Val Pro Lys Asp Gly Gln Ser His Cys Cys Ile Pro Arg Lys His 
            180                 185                 190         


Leu Leu Leu Tyr Gln Asn Met Gly Ile Trp Val Gln Ala Glu Asn Ala 
        195                 200                 205             


Leu Gly Thr Ser Met Ser Pro Gln Leu Cys Leu Asp Pro Met Asp Val 
    210                 215                 220                 


Val Lys Leu Glu Pro Pro Met Leu Arg Thr Met Asp Pro Ser Pro Glu 
225                 230                 235                 240 


Ala Ala Pro Pro Gln Ala Gly Cys Leu Gln Leu Cys Trp Glu Pro Trp 
                245                 250                 255     


Gln Pro Gly Leu His Ile Asn Gln Lys Cys Glu Leu Arg His Lys Pro 
            260                 265                 270         


Gln Arg Gly Glu Ala Ser Trp Ala Leu Val Gly Pro Leu Pro Leu Glu 
        275                 280                 285             


Ala Leu Gln Tyr Glu Leu Cys Gly Leu Leu Pro Ala Thr Ala Tyr Thr 
    290                 295                 300                 


Leu Gln Ile Arg Cys Ile Arg Trp Pro Leu Pro Gly His Trp Ser Asp 
305                 310                 315                 320 


Trp Ser Pro Ser Leu Glu Leu Arg Thr Thr Glu Arg Ala Pro Thr Val 
                325                 330                 335     


Arg Leu Asp Thr Trp Trp Arg Gln Arg Gln Leu Asp Pro Arg Thr Val 
            340                 345                 350         


Gln Leu Phe Trp Lys Pro Val Pro Leu Glu Glu Asp Ser Gly Arg Ile 
        355                 360                 365             


Gln Gly Tyr Val Val Ser Trp Arg Pro Ser Gly Gln Ala Gly Ala Ile 
    370                 375                 380                 


Leu Pro Leu Cys Asn Thr Thr Glu Leu Ser Cys Thr Phe His Leu Pro 
385                 390                 395                 400 


Ser Glu Ala Gln Glu Val Ala Leu Val Ala Tyr Asn Ser Ala Gly Thr 
                405                 410                 415     


Ser Arg Pro Thr Pro Val Val Phe Ser Glu Ser Arg Gly Pro Ala Leu 
            420                 425                 430         


Thr Arg Leu His Ala Met Ala Arg Asp Pro His Ser Leu Trp Val Gly 
        435                 440                 445             


Trp Glu Pro Pro Asn Pro Trp Pro Gln Gly Tyr Val Ile Glu Trp Gly 
    450                 455                 460                 


Leu Gly Pro Pro Ser Ala Ser Asn Ser Asn Lys Thr Trp Arg Met Glu 
465                 470                 475                 480 


Gln Asn Gly Arg Ala Thr Gly Phe Leu Leu Lys Glu Asn Ile Arg Pro 
                485                 490                 495     


Phe Gln Leu Tyr Glu Ile Ile Val Thr Pro Leu Tyr Gln Asp Thr Met 
            500                 505                 510         


Gly Pro Ser Gln His Val Tyr Ala Tyr Ser Gln Glu Met Ala Pro Ser 
        515                 520                 525             


His Ala Pro Glu Leu His Leu Lys His Ile Gly Lys Thr Trp Ala Gln 
    530                 535                 540                 


Leu Glu Trp Val Pro Glu Pro Pro Glu Leu Gly Lys Ser Pro Leu Thr 
545                 550                 555                 560 


His Tyr Thr Ile Phe Trp Thr Asn Ala Gln Asn Gln Ser Phe Ser Ala 
                565                 570                 575     


Ile Leu Asn Ala Ser Ser Arg Gly Phe Val Leu His Gly Leu Glu Pro 
            580                 585                 590         


Ala Ser Leu Tyr His Ile His Leu Met Ala Ala Ser Gln Ala Gly Ala 
        595                 600                 605             


Thr Asn Ser Thr Val Leu Thr Leu Met Thr Leu Thr Pro Glu Gly Ser 
    610                 615                 620                 


Glu Leu His Ile Ile Leu Gly Leu Phe Gly Leu Leu Leu Leu Leu Thr 
625                 630                 635                 640 


Cys Leu Cys Gly Thr Ala Trp Leu Cys Cys Ser Pro Asn Arg Lys Asn 
                645                 650                 655     


Pro Leu Trp Pro Ser Val Pro Asp Pro Ala His Ser Ser Leu Gly Ser 
            660                 665                 670         


Trp Val Pro Thr Ile Met Glu Glu Leu Pro Gly Pro Arg Gln Gly Gln 
        675                 680                 685             


Trp Leu Gly Gln Thr Ser Glu Met Ser Arg Ala Leu Thr Pro His Pro 
    690                 695                 700                 


Cys Val Gln Asp Ala Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile 
705                 710                 715                 720 


Thr Lys Leu Thr Val Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp 
                725                 730                 735     


Glu Ser His Asn Ser Ser Glu Thr Cys Gly Leu Pro Thr Leu Val Gln 
            740                 745                 750         


Thr Tyr Val Leu Gln Gly Asp Pro Arg Ala Val Ser Thr Gln Pro Gln 
        755                 760                 765             


Ser Gln Ser Gly Thr Ser Asp Gln Val Leu Tyr Gly Gln Leu Leu Gly 
    770                 775                 780                 


Ser Pro Thr Ser Pro Gly Pro Gly His Tyr Leu Arg Cys Asp Ser Thr 
785                 790                 795                 800 


Gln Pro Leu Leu Ala Gly Leu Thr Pro Ser Pro Lys Ser Tyr Glu Asn 
                805                 810                 815     


Leu Trp Phe Gln Ala Ser Pro Leu Gly Thr Leu Val Thr Pro Ala Pro 
            820                 825                 830         


Ser Gln Glu Asp Asp Cys Val Phe Gly Pro Leu Leu Asn Phe Pro Leu 
        835                 840                 845             


Leu Gln Gly Ile Arg Val His Gly Met Glu Ala Leu Gly Ser Phe 
    850                 855                 860             


<210>  6245
<211>  1042
<212>  PRT
<213>  Homo sapiens

<400>  6245

Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 
1               5                   10                  15      


Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
            20                  25                  30          


Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              


Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 
            180                 185                 190         


Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val 
    210                 215                 220                 


Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val 
225                 230                 235                 240 


Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
            260                 265                 270         


Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             


Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile 
        355                 360                 365             


Leu Asp Arg Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Thr Ile 
    370                 375                 380                 


Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val His Lys Asp Asp Lys 
385                 390                 395                 400 


Pro Val Asn Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys 
    450                 455                 460                 


Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe 
            500                 505                 510         


Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 
        515                 520                 525             


Val Gly Ser Thr Lys Val Pro Met Thr Ser Gly Val Lys Gln Lys Ile 
    530                 535                 540                 


Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 
545                 550                 555                 560 


Leu Ala Leu Ala Thr His Asp Asn Pro Leu Arg Arg Glu Glu Met His 
                565                 570                 575     


Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe 
            580                 585                 590         


Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser 
        595                 600                 605             


Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr 
    610                 615                 620                 


Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 
625                 630                 635                 640 


Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 
                645                 650                 655     


Phe Asp Glu Leu Asn Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 
            660                 665                 670         


Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 
        675                 680                 685             


Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val 
    690                 695                 700                 


Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly 
705                 710                 715                 720 


Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp 
                725                 730                 735     


Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 
            740                 745                 750         


Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 
        755                 760                 765             


Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 
    770                 775                 780                 


Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 
785                 790                 795                 800 


Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 
                805                 810                 815     


Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu 
            820                 825                 830         


Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val 
        835                 840                 845             


Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 
    850                 855                 860                 


Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro 
865                 870                 875                 880 


Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met 
                885                 890                 895     


Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 
            900                 905                 910         


Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 
        915                 920                 925             


Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 
    930                 935                 940                 


Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro 
945                 950                 955                 960 


Leu Asn Val Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 
                965                 970                 975     


Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 
            980                 985                 990         


Pro Gly Lys Glu Cys Val Gln Pro  Ala Thr Lys Ser Cys  Ser Phe Ser 
        995                 1000                 1005             


Ala Cys  Thr Asp Gly Ile Ser  Trp Pro Phe Val Leu  Leu Ile Met 
    1010                 1015                 1020             


Pro Leu  Val Ile Trp Val Tyr  Ser Thr Asp Thr Asn  Phe Ser Asp 
    1025                 1030                 1035             


Met Phe  Trp Ser 
    1040         


<210>  6246
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  6246

Met Ala Ala Ala Gln Pro Lys Tyr Pro Ala Gly Ala Thr Ala Arg Arg 
1               5                   10                  15      


Leu Ala Arg Gly Cys Trp Ser Ala Leu Trp Asp Tyr Glu Thr Pro Lys 
            20                  25                  30          


Val Ile Val Val Arg Asn Arg Arg Leu Gly Val Leu Tyr Arg Ala Val 
        35                  40                  45              


Gln Leu Leu Ile Leu Leu Tyr Phe Val Trp Tyr Val Phe Ile Val Gln 
    50                  55                  60                  


Lys Ser Tyr Gln Glu Ser Glu Thr Gly Pro Glu Ser Ser Ile Ile Thr 
65                  70                  75                  80  


Lys Val Lys Gly Ile Thr Thr Ser Glu His Lys Val Trp Asp Val Glu 
                85                  90                  95      


Glu Tyr Val Lys Pro Pro Glu Gly Gly Ser Val Phe Ser Ile Ile Thr 
            100                 105                 110         


Arg Val Glu Ala Thr His Ser Gln Thr Gln Gly Thr Cys Pro Glu Ser 
        115                 120                 125             


Ile Arg Val His Asn Ala Thr Cys Leu Ser Asp Ala Asp Cys Val Ala 
    130                 135                 140                 


Gly Glu Leu Asp Met Leu Gly Asn Gly Leu Arg Thr Gly Arg Cys Val 
145                 150                 155                 160 


Pro Tyr Tyr Gln Gly Pro Ser Lys Thr Cys Glu Val Phe Gly Trp Cys 
                165                 170                 175     


Pro Val Glu Asp Gly Ala Ser Val Ser Gln Phe Leu Gly Thr Met Ala 
            180                 185                 190         


Pro Asn Phe Thr Ile Leu Ile Lys Asn Ser Ile His Tyr Pro Lys Phe 
        195                 200                 205             


His Phe Ser Lys Gly Asn Ile Ala Asp Arg Thr Asp Gly Tyr Leu Lys 
    210                 215                 220                 


Arg Cys Thr Phe His Glu Ala Ser Asp Leu Tyr Cys Pro Ile Phe Lys 
225                 230                 235                 240 


Leu Gly Phe Ile Val Glu Lys Ala Gly Glu Ser Phe Thr Glu Leu Ala 
                245                 250                 255     


His Lys Gly Gly Val Ile Gly Val Ile Ile Asn Trp Asp Cys Asp Leu 
            260                 265                 270         


Asp Leu Pro Ala Ser Glu Cys Asn Pro Lys Tyr Ser Phe Arg Arg Leu 
        275                 280                 285             


Asp Pro Lys His Val Pro Ala Ser Ser Gly Tyr Asn Phe Arg Phe Ala 
    290                 295                 300                 


Lys Tyr Tyr Lys Ile Asn Gly Thr Thr Thr Arg Thr Leu Ile Lys Ala 
305                 310                 315                 320 


Tyr Gly Ile Arg Ile Asp Val Ile Val His Gly Gln Ala Gly Lys Phe 
                325                 330                 335     


Ser Leu Ile Pro Thr Ile Ile Asn Leu Ala Thr Ala Leu Thr Ser Val 
            340                 345                 350         


Gly Val Gly Ser Phe Leu Cys Asp Trp Ile Leu Leu Thr Phe Met Asn 
        355                 360                 365             


Lys Asn Lys Val Tyr Ser His Lys Lys Phe Asp Lys Val Cys Thr Pro 
    370                 375                 380                 


Ser His Pro Ser Gly Ser Trp Pro Val Thr Leu Ala Arg Val Leu Gly 
385                 390                 395                 400 


Gln Ala Pro Pro Glu Pro Gly His Arg Ser Glu Asp Gln His Pro Ser 
                405                 410                 415     


Pro Pro Ser Gly Gln Glu Gly Gln Gln Gly Ala Glu Cys Gly Pro Ala 
            420                 425                 430         


Phe Pro Pro Leu Arg Pro Cys Pro Ile Ser Ala Pro Ser Glu Gln Met 
        435                 440                 445             


Val Asp Thr Pro Ala Ser Glu Pro Ala Gln Ala Ser Thr Pro Thr Asp 
    450                 455                 460                 


Pro Lys Gly Leu Ala Gln Leu 
465                 470     


<210>  6247
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  6247

Met Ala Ala Ala Gln Pro Lys Tyr Pro Ala Gly Ala Thr Ala Arg Arg 
1               5                   10                  15      


Leu Ala Arg Gly Cys Trp Ser Ala Leu Trp Asp Tyr Glu Thr Pro Lys 
            20                  25                  30          


Val Ile Val Val Arg Asn Arg Arg Leu Gly Val Leu Tyr Arg Ala Val 
        35                  40                  45              


Gln Leu Leu Ile Leu Leu Tyr Phe Val Trp Tyr Val Phe Ile Val Gln 
    50                  55                  60                  


Lys Ser Tyr Gln Glu Ser Glu Thr Gly Pro Glu Ser Ser Ile Ile Thr 
65                  70                  75                  80  


Lys Val Lys Gly Ile Thr Thr Ser Glu His Lys Val Trp Asp Val Glu 
                85                  90                  95      


Glu Tyr Val Lys Pro Pro Glu Gly Gly Ser Val Phe Ser Ile Ile Thr 
            100                 105                 110         


Arg Val Glu Ala Thr His Ser Gln Thr Gln Gly Thr Cys Pro Glu Ser 
        115                 120                 125             


Ile Arg Val His Asn Ala Thr Cys Leu Ser Asp Ala Asp Cys Val Ala 
    130                 135                 140                 


Gly Glu Leu Asp Met Leu Gly Asn Gly Leu Arg Thr Gly Arg Cys Val 
145                 150                 155                 160 


Pro Tyr Tyr Gln Gly Pro Ser Lys Thr Cys Glu Val Phe Gly Trp Cys 
                165                 170                 175     


Pro Val Glu Asp Gly Ala Ser Val Ser Gln Phe Leu Gly Thr Met Ala 
            180                 185                 190         


Pro Asn Phe Thr Ile Leu Ile Lys Asn Ser Ile His Tyr Pro Lys Phe 
        195                 200                 205             


His Phe Ser Lys Gly Asn Ile Ala Asp Arg Thr Asp Gly Tyr Leu Lys 
    210                 215                 220                 


Arg Cys Thr Phe His Glu Ala Ser Asp Leu Tyr Cys Pro Ile Phe Lys 
225                 230                 235                 240 


Leu Gly Phe Ile Val Glu Lys Ala Gly Glu Ser Phe Thr Glu Leu Ala 
                245                 250                 255     


His Lys Gly Gly Val Ile Gly Val Ile Ile Asn Trp Asp Cys Asp Leu 
            260                 265                 270         


Asp Leu Pro Ala Ser Glu Cys Asn Pro Lys Tyr Ser Phe Arg Arg Leu 
        275                 280                 285             


Asp Pro Lys His Val Pro Ala Ser Ser Gly Tyr Asn Phe Arg Phe Ala 
    290                 295                 300                 


Lys Tyr Tyr Lys Ile Asn Gly Thr Thr Thr Arg Thr Leu Ile Lys Ala 
305                 310                 315                 320 


Tyr Gly Ile Arg Ile Asp Val Ile Val His Gly Gln Ala Gly Lys Phe 
                325                 330                 335     


Ser Leu Ile Pro Thr Ile Ile Asn Leu Ala Thr Ala Leu Thr Ser Val 
            340                 345                 350         


Gly Val Val Arg Asn Pro Leu Trp Gly Pro Ser Gly Cys Gly Gly Ser 
        355                 360                 365             


Thr Arg Pro Leu His Thr Gly Leu Cys Trp Pro Gln Gly Ser Phe Leu 
    370                 375                 380                 


Cys Asp Trp Ile Leu Leu Thr Phe Met Asn Lys Asn Lys Val Tyr Ser 
385                 390                 395                 400 


His Lys Lys Phe Asp Lys Val Cys Thr Pro Ser His Pro Ser Gly Ser 
                405                 410                 415     


Trp Pro Val Thr Leu Ala Arg Val Leu Gly Gln Ala Pro Pro Glu Pro 
            420                 425                 430         


Gly His Arg Ser Glu Asp Gln His Pro Ser Pro Pro Ser Gly Gln Glu 
        435                 440                 445             


Gly Gln Gln Gly Ala Glu Cys Gly Pro Ala Phe Pro Pro Leu Arg Pro 
    450                 455                 460                 


Cys Pro Ile Ser Ala Pro Ser Glu Gln Met Val Asp Thr Pro Ala Ser 
465                 470                 475                 480 


Glu Pro Ala Gln Ala Ser Thr Pro Thr Asp Pro Lys Gly Leu Ala Gln 
                485                 490                 495     


Leu 
    


<210>  6248
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  6248

Met Thr Pro Asn Ser Thr Gly Glu Val Pro Ser Pro Ile Pro Lys Gly 
1               5                   10                  15      


Ala Leu Gly Leu Ser Leu Ala Leu Ala Ser Leu Ile Ile Thr Ala Asn 
            20                  25                  30          


Leu Leu Leu Ala Leu Gly Ile Ala Trp Asp Arg Arg Leu Arg Ser Pro 
        35                  40                  45              


Pro Ala Gly Cys Phe Phe Leu Ser Leu Leu Leu Ala Gly Leu Leu Thr 
    50                  55                  60                  


Gly Leu Ala Leu Pro Thr Leu Pro Gly Leu Trp Asn Gln Ser Arg Arg 
65                  70                  75                  80  


Gly Tyr Trp Ser Cys Leu Leu Val Tyr Leu Ala Pro Asn Phe Ser Phe 
                85                  90                  95      


Leu Ser Leu Leu Ala Asn Leu Leu Leu Val His Gly Glu Arg Tyr Met 
            100                 105                 110         


Ala Val Leu Arg Pro Leu Gln Pro Pro Gly Ser Ile Arg Leu Ala Leu 
        115                 120                 125             


Leu Leu Thr Trp Ala Gly Pro Leu Leu Phe Ala Ser Leu Pro Ala Leu 
    130                 135                 140                 


Gly Trp Asn His Trp Thr Pro Gly Ala Asn Cys Ser Ser Gln Ala Ile 
145                 150                 155                 160 


Phe Pro Ala Pro Tyr Leu Tyr Leu Glu Val Tyr Gly Leu Leu Leu Pro 
                165                 170                 175     


Ala Val Gly Ala Ala Ala Phe Leu Ser Val Arg Val Leu Ala Thr Ala 
            180                 185                 190         


His Arg Gln Leu Gln Asp Ile Cys Arg Leu Glu Arg Ala Val Cys Arg 
        195                 200                 205             


Asp Glu Pro Ser Ala Leu Ala Arg Ala Leu Thr Trp Arg Gln Ala Arg 
    210                 215                 220                 


Ala Gln Ala Gly Ala Met Leu Leu Phe Gly Leu Cys Trp Gly Pro Tyr 
225                 230                 235                 240 


Val Ala Thr Leu Leu Leu Ser Val Leu Ala Tyr Glu Gln Arg Pro Pro 
                245                 250                 255     


Leu Gly Pro Gly Thr Leu Leu Ser Leu Leu Ser Leu Gly Ser Ala Ser 
            260                 265                 270         


Ala Ala Ala Val Pro Val Ala Met Gly Leu Gly Asp Gln Arg Tyr Thr 
        275                 280                 285             


Ala Pro Trp Arg Ala Ala Ala Gln Arg Cys Leu Gln Gly Leu Trp Gly 
    290                 295                 300                 


Arg Ala Ser Arg Asp Ser Pro Gly Pro Ser Ile Ala Tyr His Pro Ser 
305                 310                 315                 320 


Ser Gln Ser Ser Val Asp Leu Asp Leu Asn 
                325                 330 


<210>  6249
<211>  436
<212>  PRT
<213>  Homo sapiens

<400>  6249

Met Gly Leu Ala Arg Ala Leu Arg Arg Leu Ser Gly Ala Leu Asp Ser 
1               5                   10                  15      


Gly Asp Ser Arg Ala Gly Asp Glu Glu Glu Ala Gly Pro Gly Leu Cys 
            20                  25                  30          


Arg Asn Gly Trp Ala Pro Ala Pro Val Gln Ser Pro Val Gly Arg Arg 
        35                  40                  45              


Arg Gly Arg Phe Val Lys Lys Asp Gly His Cys Asn Val Arg Phe Val 
    50                  55                  60                  


Asn Leu Gly Gly Gln Gly Ala Arg Tyr Leu Ser Asp Leu Phe Thr Thr 
65                  70                  75                  80  


Cys Val Asp Val Arg Trp Arg Trp Met Cys Leu Leu Phe Ser Cys Ser 
                85                  90                  95      


Phe Leu Ala Ser Trp Leu Leu Phe Gly Leu Ala Phe Trp Leu Ile Ala 
            100                 105                 110         


Ser Leu His Gly Asp Leu Ala Ala Pro Pro Pro Pro Ala Pro Cys Phe 
        115                 120                 125             


Ser His Val Ala Ser Phe Leu Ala Ala Phe Leu Phe Ala Leu Glu Thr 
    130                 135                 140                 


Gln Thr Ser Ile Gly Tyr Gly Val Arg Ser Val Thr Glu Glu Cys Pro 
145                 150                 155                 160 


Ala Ala Val Ala Ala Val Val Leu Gln Cys Ile Ala Gly Cys Val Leu 
                165                 170                 175     


Asp Ala Phe Val Val Gly Ala Val Met Ala Lys Met Ala Lys Pro Lys 
            180                 185                 190         


Lys Arg Asn Glu Thr Leu Val Phe Ser Glu Asn Ala Val Val Ala Leu 
        195                 200                 205             


Arg Asp His Arg Leu Cys Leu Met Trp Arg Val Gly Asn Leu Arg Arg 
    210                 215                 220                 


Ser His Leu Val Glu Ala His Val Arg Ala Gln Leu Leu Gln Pro Arg 
225                 230                 235                 240 


Val Thr Pro Glu Gly Glu Tyr Ile Pro Leu Asp His Gln Asp Val Asp 
                245                 250                 255     


Val Gly Phe Asp Gly Gly Thr Asp Arg Ile Phe Leu Val Ser Pro Ile 
            260                 265                 270         


Thr Ile Val His Glu Ile Asp Ser Ala Ser Pro Leu Tyr Glu Leu Gly 
        275                 280                 285             


Arg Ala Glu Leu Ala Arg Ala Asp Phe Glu Leu Val Val Ile Leu Glu 
    290                 295                 300                 


Gly Met Val Glu Ala Thr Ala Met Thr Thr Gln Cys Arg Ser Ser Tyr 
305                 310                 315                 320 


Leu Pro Gly Glu Leu Leu Trp Gly His Arg Phe Glu Pro Val Leu Phe 
                325                 330                 335     


Gln Arg Gly Ser Gln Tyr Glu Val Asp Tyr Arg His Phe His Arg Thr 
            340                 345                 350         


Tyr Glu Val Pro Gly Thr Pro Val Cys Ser Ala Lys Glu Leu Asp Glu 
        355                 360                 365             


Arg Ala Glu Gln Ala Ser His Ser Leu Lys Ser Ser Phe Pro Gly Ser 
    370                 375                 380                 


Leu Thr Ala Phe Cys Tyr Glu Asn Glu Leu Ala Leu Ser Cys Cys Gln 
385                 390                 395                 400 


Glu Glu Asp Glu Asp Asp Glu Thr Glu Glu Gly Asn Gly Val Glu Thr 
                405                 410                 415     


Glu Asp Gly Ala Ala Ser Pro Arg Val Leu Thr Pro Thr Leu Ala Leu 
            420                 425                 430         


Thr Leu Pro Pro 
        435     


<210>  6250
<211>  3396
<212>  PRT
<213>  Homo sapiens

<400>  6250

Met Thr Ala Trp Leu Ile Ser Leu Met Ser Ile Glu Val Leu Leu Leu 
1               5                   10                  15      


Ala Val Arg His Leu Ser Leu His Ile Glu Pro Glu Glu Gly Ser Leu 
            20                  25                  30          


Ala Gly Gly Thr Trp Ile Thr Val Ile Phe Asp Gly Leu Glu Leu Gly 
        35                  40                  45              


Val Leu Tyr Pro Asn Asn Gly Ser Gln Leu Glu Ile His Leu Val Asn 
    50                  55                  60                  


Val Asn Met Val Val Pro Ala Leu Arg Ser Val Pro Cys Asp Val Phe 
65                  70                  75                  80  


Pro Val Phe Leu Asp Leu Pro Val Val Thr Cys Arg Thr Arg Ser Val 
                85                  90                  95      


Leu Ser Glu Ala His Glu Gly Leu Tyr Phe Leu Glu Ala Tyr Phe Gly 
            100                 105                 110         


Gly Gln Leu Val Ser Ser Pro Asn Pro Gly Pro Arg Asp Ser Cys Thr 
        115                 120                 125             


Phe Lys Phe Ser Lys Ala Gln Thr Pro Ile Val His Gln Val Tyr Pro 
    130                 135                 140                 


Pro Ser Gly Val Pro Gly Lys Leu Ile His Val Tyr Gly Trp Ile Ile 
145                 150                 155                 160 


Thr Gly Arg Leu Glu Thr Phe Asp Phe Asp Ala Glu Tyr Ile Asp Ser 
                165                 170                 175     


Pro Val Ile Leu Glu Ala Gln Gly Asp Lys Trp Val Thr Pro Cys Ser 
            180                 185                 190         


Leu Ile Asn Arg Gln Met Gly Ser Cys Tyr Pro Ile Gln Glu Asp His 
        195                 200                 205             


Gly Leu Gly Thr Leu Gln Cys His Val Glu Gly Asp Tyr Ile Gly Ser 
    210                 215                 220                 


Gln Asn Val Ser Phe Ser Val Phe Asn Lys Gly Lys Ser Met Val His 
225                 230                 235                 240 


Lys Lys Ala Trp Leu Ile Ser Ala Lys Gln Asp Leu Phe Leu Tyr Gln 
                245                 250                 255     


Thr His Ser Glu Ile Leu Ser Val Phe Pro Glu Thr Gly Ser Leu Gly 
            260                 265                 270         


Gly Arg Thr Asn Ile Thr Ile Thr Gly Asp Phe Phe Asp Asn Ser Ala 
        275                 280                 285             


Gln Val Thr Ile Ala Gly Ile Pro Cys Asp Ile Arg His Val Ser Pro 
    290                 295                 300                 


Arg Lys Ile Glu Cys Thr Thr Arg Ala Pro Gly Lys Asp Val Arg Leu 
305                 310                 315                 320 


Thr Thr Pro Gln Pro Gly Asn Arg Gly Leu Leu Phe Glu Val Gly Asp 
                325                 330                 335     


Ala Val Glu Gly Leu Glu Leu Thr Glu Ala Thr Pro Gly Tyr Arg Trp 
            340                 345                 350         


Gln Ile Val Pro Asn Ala Ser Ser Pro Phe Gly Phe Trp Ser Gln Glu 
        355                 360                 365             


Gly Gln Pro Phe Arg Ala Arg Leu Ser Gly Phe Phe Val Ala Pro Glu 
    370                 375                 380                 


Thr Asn Asn Tyr Thr Phe Trp Ile Gln Ala Asp Ser Gln Ala Ser Leu 
385                 390                 395                 400 


His Phe Ser Trp Ser Glu Glu Pro Arg Thr Lys Val Lys Val Ala Ser 
                405                 410                 415     


Ile Ser Val Gly Thr Ala Asp Trp Phe Asp Ser Trp Glu Gln Asn Arg 
            420                 425                 430         


Asp Glu Gly Thr Trp Gln Gln Lys Thr Pro Lys Leu Glu Leu Leu Gly 
        435                 440                 445             


Gly Ala Met Tyr Tyr Leu Glu Ala Glu His His Gly Ile Ala Pro Ser 
    450                 455                 460                 


Arg Gly Met Arg Ile Gly Val Gln Ile His Asn Thr Trp Leu Asn Pro 
465                 470                 475                 480 


Asp Val Val Thr Thr Tyr Leu Arg Glu Lys His Gln Ile Arg Val Arg 
                485                 490                 495     


Ala Gln Arg Leu Pro Glu Val Gln Val Leu Asn Val Ser Gly Arg Gly 
            500                 505                 510         


Asn Phe Phe Leu Thr Trp Asp Asn Val Ser Ser Gln Pro Ile Pro Ala 
        515                 520                 525             


Asn Ala Thr Ala His Leu Ile Gln Thr Thr Ile Glu Glu Leu Leu Ala 
    530                 535                 540                 


Val Lys Cys Lys Leu Glu Pro Leu Trp Ser Asn Ile Leu Leu Arg Leu 
545                 550                 555                 560 


Gly Phe Glu Arg Gly Pro Glu Val Ser Asn Ser Asp Gly Asp Leu Thr 
                565                 570                 575     


Ser Gly Thr Glu Pro Phe Cys Gly Arg Phe Ser Leu Arg Gln Pro Arg 
            580                 585                 590         


His Leu Val Leu Thr Pro Pro Ala Ala Gln Lys Gly Tyr Arg Leu Asp 
        595                 600                 605             


Gln Tyr Thr His Leu Cys Leu Ala Tyr Lys Gly His Met Asn Lys Ile 
    610                 615                 620                 


Leu Lys Met Ile Val Ser Phe Thr Ile Gly Phe Gln Asn Met Val Lys 
625                 630                 635                 640 


Asn Thr Thr Cys Asp Trp Ser Leu Thr Arg Thr Ser Pro Glu Ser Trp 
                645                 650                 655     


Gln Phe Asp Cys Thr Asp Leu Trp Glu Thr Cys Val Arg Cys Phe Gly 
            660                 665                 670         


Asp Leu Gln Pro Pro Pro Ala Asn Ser Pro Val Leu Val His Gln Ile 
        675                 680                 685             


Asn Leu Leu Pro Leu Ala Gln Glu Thr Gly Leu Phe Tyr Val Asp Glu 
    690                 695                 700                 


Ile Ile Ile Ala Asp Thr Asn Val Thr Val Ser Gln Ala Asp Ser Gly 
705                 710                 715                 720 


Thr Ala Arg Pro Gly Gly Asn Leu Val Glu Ser Val Ser Val Val Gly 
                725                 730                 735     


Ser Pro Pro Val Tyr Ser Val Thr Ser Trp Leu Ala Gly Cys Gly Thr 
            740                 745                 750         


Glu Leu Pro Leu Ile Thr Ala Arg Ser Val Pro Thr Glu Gly Thr Glu 
        755                 760                 765             


Glu Gly Ser Gly Leu Val Leu Val Thr Thr Gln Arg Arg Gln Arg Thr 
    770                 775                 780                 


Ser Pro Pro Leu Gly Gly His Phe Arg Ile Gln Leu Pro Asn Thr Val 
785                 790                 795                 800 


Ile Ser Asp Val Pro Val Gln Ile Ser Ala His His Leu His Gln Leu 
                805                 810                 815     


Leu Gln Asn Asn Ala Asp Asp Phe Thr Ser Arg Tyr Leu Asn Ala Ser 
            820                 825                 830         


Asp Phe Thr Val Lys Glu Asp Leu Tyr Thr Cys Tyr Glu His Val Trp 
        835                 840                 845             


Thr Leu Ser Trp Ser Thr Gln Ile Gly Asp Leu Pro Asn Phe Ile Arg 
    850                 855                 860                 


Val Ser Asp Glu Asn Leu Thr Gly Val Asn Pro Ala Ala Ala Thr Arg 
865                 870                 875                 880 


Val Val Tyr Asp Gly Gly Val Phe Leu Gly Pro Ile Phe Gly Asp Met 
                885                 890                 895     


Leu Ala Thr Ala Asn Gln His Thr Gln Val Val Val Arg Val Asn Asp 
            900                 905                 910         


Val Pro Ala His Cys Pro Gly Ser Cys Ser Phe Gln Tyr Leu Gln Gly 
        915                 920                 925             


Ser Thr Pro Cys Val His Ser Val Trp Tyr Ser Ile Asp Gly Asp Ile 
    930                 935                 940                 


Asn Leu Met Ile Tyr Ile Thr Gly Thr Gly Phe Ser Gly Asp Ser Gln 
945                 950                 955                 960 


Phe Leu Gln Val Thr Val Asn Lys Thr Ser Cys Lys Val Ile Phe Ser 
                965                 970                 975     


Asn Gln Thr Asn Val Val Cys Gln Thr Asp Leu Leu Pro Val Gly Met 
            980                 985                 990         


His Arg Ile Leu Met Leu Val Arg  Pro Ser Gly Leu Ala  Ile Ser Ala 
        995                 1000                 1005             


Thr Gly  Glu Asp Leu Phe Leu  Asn Val Lys Pro Arg  Leu Asp Met 
    1010                 1015                 1020             


Val Glu  Pro Ser Arg Ala Ala  Asp Ile Gly Gly Leu  Trp Ala Thr 
    1025                 1030                 1035             


Ile Arg  Gly Ser Ser Leu Glu  Gly Val Ser Leu Ile  Leu Phe Gly 
    1040                 1045                 1050             


Ser Tyr  Ser Cys Ala Ile Asn  Val Ala Thr Ser Asn  Ser Ser Arg 
    1055                 1060                 1065             


Ile Gln  Cys Lys Val Pro Pro  Arg Gly Lys Asp Gly  Arg Ile Val 
    1070                 1075                 1080             


Asn Val  Thr Val Ile Arg Gly  Asp Tyr Ser Ala Val  Leu Pro Arg 
    1085                 1090                 1095             


Ala Phe  Thr Tyr Val Ser Ser  Leu Asn Pro Val Ile  Val Thr Leu 
    1100                 1105                 1110             


Ser Arg  Asn Ile Ser Asn Ile  Ala Gly Gly Glu Thr  Leu Val Ile 
    1115                 1120                 1125             


Gly Val  Ala Arg Leu Met Asn  Tyr Thr Asp Leu Asp  Val Glu Val 
    1130                 1135                 1140             


His Val  Gln Asp Ala Leu Ala  Pro Val His Thr Gln  Ser Ala Trp 
    1145                 1150                 1155             


Gly Leu  Glu Val Ala Leu Pro  Pro Leu Pro Ala Gly  Leu His Arg 
    1160                 1165                 1170             


Ile Ser  Val Ser Ile Asn Gly  Val Ser Ile His Ser  Gln Gly Val 
    1175                 1180                 1185             


Asp Leu  His Ile Gln Tyr Leu  Thr Glu Val Phe Ser  Ile Glu Pro 
    1190                 1195                 1200             


Cys Cys  Gly Ser Leu Leu Gly  Gly Thr Ile Leu Ser  Ile Ser Gly 
    1205                 1210                 1215             


Ile Gly  Phe Ser Arg Asp Pro  Ala Leu Val Trp Val  Leu Val Gly 
    1220                 1225                 1230             


Asn Arg  Ser Cys Asp Ile Val  Asn Leu Thr Glu Ala  Ser Ile Trp 
    1235                 1240                 1245             


Cys Glu  Thr Leu Pro Ala Pro  Gln Ile Pro Asp Ala  Gly Ala Pro 
    1250                 1255                 1260             


Thr Val  Pro Ala Ala Val Glu  Val Trp Ala Gly Asn  Arg Phe Phe 
    1265                 1270                 1275             


Ala Arg  Gly Pro Ser Pro Ser  Leu Val Gly Lys Gly  Phe Thr Phe 
    1280                 1285                 1290             


Met Tyr  Glu Ala Ala Ala Thr  Pro Val Val Thr Ala  Met Gln Gly 
    1295                 1300                 1305             


Glu Ile  Thr Asn Ser Ser Leu  Ser Leu His Val Gly  Gly Ser Asn 
    1310                 1315                 1320             


Leu Ser  Asn Ser Val Ile Leu  Leu Gly Asn Leu Asn  Cys Asp Val 
    1325                 1330                 1335             


Glu Thr  Gln Ser Phe Gln Gly  Asn Val Ser Leu Ser  Gly Cys Ser 
    1340                 1345                 1350             


Ile Pro  Leu His Ser Leu Glu  Ala Gly Ile Tyr Pro  Leu Gln Val 
    1355                 1360                 1365             


Arg Gln  Lys Gln Met Gly Phe  Ala Asn Met Ser Val  Val Leu Gln 
    1370                 1375                 1380             


Gln Phe  Ala Val Met Pro Arg  Ile Met Ala Ile Phe  Pro Ser Gln 
    1385                 1390                 1395             


Gly Ser  Ala Cys Gly Gly Thr  Ile Leu Thr Val Arg  Gly Leu Leu 
    1400                 1405                 1410             


Leu Asn  Ser Arg Arg Arg Ser  Val Arg Val Asp Leu  Ser Gly Pro 
    1415                 1420                 1425             


Phe Thr  Cys Val Ile Leu Ser  Leu Gly Asp His Thr  Ile Leu Cys 
    1430                 1435                 1440             


Gln Val  Ser Leu Glu Gly Asp  Pro Leu Pro Gly Ala  Ser Phe Ser 
    1445                 1450                 1455             


Leu Asn  Val Thr Val Leu Val  Asn Gly Leu Thr Ser  Glu Cys Gln 
    1460                 1465                 1470             


Gly Asn  Cys Thr Leu Phe Ile  Arg Glu Glu Ala Ser  Pro Val Met 
    1475                 1480                 1485             


Asp Ala  Leu Ser Thr Asn Thr  Ser Gly Ser Leu Thr  Thr Val Leu 
    1490                 1495                 1500             


Ile Arg  Gly Gln Arg Leu Ala  Thr Thr Ala Asp Glu  Pro Met Val 
    1505                 1510                 1515             


Phe Val  Asp Asp Gln Leu Pro  Cys Asn Val Thr Phe  Phe Asn Ala 
    1520                 1525                 1530             


Ser His  Val Val Cys Gln Thr  Arg Asp Leu Ala Pro  Gly Pro His 
    1535                 1540                 1545             


Tyr Leu  Ser Val Phe Tyr Thr  Arg Asn Gly Tyr Ala  Cys Ser Gly 
    1550                 1555                 1560             


Asn Val  Ser Arg His Phe Tyr  Ile Met Pro Gln Val  Phe His Tyr 
    1565                 1570                 1575             


Phe Pro  Lys Asn Phe Ser Leu  His Gly Gly Ser Leu  Leu Thr Ile 
    1580                 1585                 1590             


Glu Gly  Thr Gly Leu Arg Gly  Gln Asn Thr Thr Ser  Val Tyr Ile 
    1595                 1600                 1605             


Asp Gln  Gln Thr Cys Leu Thr  Val Asn Ile Gly Ala  Glu Leu Ile 
    1610                 1615                 1620             


Arg Cys  Ile Val Pro Thr Gly  Asn Gly Ser Val Ala  Leu Glu Ile 
    1625                 1630                 1635             


Glu Val  Asp Gly Leu Trp Tyr  His Ile Gly Val Ile  Gly Tyr Asn 
    1640                 1645                 1650             


Lys Ala  Phe Thr Pro Glu Leu  Ile Ser Ile Ser Gln  Ser Asp Asp 
    1655                 1660                 1665             


Ile Leu  Thr Phe Ala Val Ala  Gln Ile Ser Gly Ala  Ala Asn Ile 
    1670                 1675                 1680             


Asp Ile  Phe Ile Gly Met Ser  Pro Cys Val Gly Val  Ser Gly Asn 
    1685                 1690                 1695             


His Thr  Val Leu Gln Cys Val  Val Pro Ser Leu Pro  Ala Gly Glu 
    1700                 1705                 1710             


Tyr His  Val Arg Gly Tyr Asp  Cys Ile Arg Gly Trp  Ala Ser Ser 
    1715                 1720                 1725             


Ala Leu  Val Phe Thr Ser Arg  Val Ile Ile Thr Ala  Val Thr Glu 
    1730                 1735                 1740             


Asn Phe  Gly Cys Leu Gly Gly  Arg Leu Val His Val  Phe Gly Ala 
    1745                 1750                 1755             


Gly Phe  Ser Pro Gly Asn Val  Ser Ala Ala Val Cys  Gly Ala Pro 
    1760                 1765                 1770             


Cys Arg  Val Leu Ala Asn Ala  Thr Val Ser Ala Phe  Ser Cys Leu 
    1775                 1780                 1785             


Val Leu  Pro Leu Asp Val Ser  Leu Ala Phe Leu Cys  Gly Leu Lys 
    1790                 1795                 1800             


Arg Glu  Glu Asp Ser Cys Glu  Ala Ala Arg His Thr  Tyr Val Gln 
    1805                 1810                 1815             


Cys Asp  Leu Thr Val Ala Met  Ala Thr Glu Gln Leu  Leu Glu Ser 
    1820                 1825                 1830             


Trp Pro  Tyr Leu Tyr Ile Cys  Glu Glu Ser Ser Gln  Cys Leu Phe 
    1835                 1840                 1845             


Val Pro  Asp His Trp Ala Glu  Ser Met Phe Pro Ser  Phe Ser Gly 
    1850                 1855                 1860             


Leu Phe  Ile Ser Pro Lys Leu  Glu Arg Asp Glu Val  Leu Ile Tyr 
    1865                 1870                 1875             


Asn Ser  Ser Cys Asn Ile Thr  Met Glu Thr Glu Ala  Glu Met Glu 
    1880                 1885                 1890             


Cys Glu  Thr Pro Asn Gln Pro  Ile Thr Val Lys Ile  Thr Glu Ile 
    1895                 1900                 1905             


Arg Lys  Arg Trp Gly Gln Asn  Thr Gln Gly Asn Phe  Ser Leu Gln 
    1910                 1915                 1920             


Phe Cys  Arg Arg Trp Ser Arg  Thr His Ser Trp Phe  Pro Glu Arg 
    1925                 1930                 1935             


Leu Pro  Gln Asp Gly Asp Asn  Val Thr Val Glu Asn  Gly Gln Leu 
    1940                 1945                 1950             


Leu Leu  Leu Asp Thr Asn Thr  Ser Ile Leu Asn Leu  Leu His Ile 
    1955                 1960                 1965             


Lys Gly  Gly Lys Leu Ile Phe  Met Ala Pro Gly Pro  Ile Glu Leu 
    1970                 1975                 1980             


Arg Ala  His Ala Ile Leu Val  Ser Asp Gly Gly Glu  Leu Arg Ile 
    1985                 1990                 1995             


Gly Ser  Glu Asp Lys Pro Phe  Gln Gly Arg Ala Gln  Ile Thr Leu 
    2000                 2005                 2010             


Tyr Gly  Ser Ser Tyr Ser Thr  Pro Phe Phe Pro Tyr  Gly Val Lys 
    2015                 2020                 2025             


Phe Leu  Ala Val Arg Asn Gly  Thr Leu Ser Leu His  Gly Ser Leu 
    2030                 2035                 2040             


Pro Glu  Val Ile Val Thr Cys  Leu Arg Ala Thr Ala  His Ala Leu 
    2045                 2050                 2055             


Asp Thr  Val Leu Ala Leu Glu  Asp Ala Val Asp Trp  Asn Pro Gly 
    2060                 2065                 2070             


Asp Glu  Val Val Ile Ile Ser  Gly Thr Gly Val Lys  Gly Ala Lys 
    2075                 2080                 2085             


Pro Met  Glu Glu Ile Val Thr  Val Glu Thr Val Gln  Asp Thr Asp 
    2090                 2095                 2100             


Leu Tyr  Leu Lys Ser Pro Leu  Arg Tyr Ser His Asn  Phe Thr Glu 
    2105                 2110                 2115             


Asn Trp  Val Ala Gly Glu His  His Ile Leu Lys Ala  Thr Val Ala 
    2120                 2125                 2130             


Leu Leu  Ser Arg Ser Ile Thr  Ile Gln Gly Asn Leu  Thr Asn Glu 
    2135                 2140                 2145             


Arg Glu  Lys Leu Leu Val Ser  Cys Gln Glu Ala Asn  Ala Pro Glu 
    2150                 2155                 2160             


Gly Asn  Leu Gln His Cys Leu  Tyr Ser Met Ser Glu  Lys Met Leu 
    2165                 2170                 2175             


Gly Ser  Arg Asp Met Gly Ala  Arg Val Ile Val Gln  Ser Phe Pro 
    2180                 2185                 2190             


Glu Glu  Pro Ser Gln Val Gln  Leu Lys Gly Val Gln  Phe Gln Val 
    2195                 2200                 2205             


Leu Gly  Gln Ala Phe His Lys  His Leu Ser Ser Leu  Thr Leu Val 
    2210                 2215                 2220             


Gly Ala  Met Arg Glu Ser Phe  Ile Gln Gly Cys Thr  Val Arg Asn 
    2225                 2230                 2235             


Ser Phe  Ser Arg Gly Leu Ser  Met Cys Gly Thr Leu  Gly Leu Lys 
    2240                 2245                 2250             


Val Asp  Ser Asn Val Phe Tyr  Asn Ile Leu Gly His  Ala Leu Leu 
    2255                 2260                 2265             


Val Gly  Thr Cys Thr Glu Met  Arg Tyr Ile Ser Trp  Glu Ala Ile 
    2270                 2275                 2280             


His Gly  Arg Lys Asp Asp Trp  Ser Gly His Gly Asn  Ile Ile Arg 
    2285                 2290                 2295             


Asn Asn  Val Ile Ile Gln Val  Ser Gly Ala Glu Gly  Leu Ser Asn 
    2300                 2305                 2310             


Pro Glu  Met Leu Thr Pro Ser  Gly Ile Tyr Ile Cys  Ser Pro Thr 
    2315                 2320                 2325             


Asn Val  Ile Glu Gly Asn Arg  Val Cys Gly Ala Gly  Tyr Gly Tyr 
    2330                 2335                 2340             


Phe Phe  His Leu Met Thr Asn  Gln Thr Ser Gln Ala  Pro Leu Leu 
    2345                 2350                 2355             


Ser Phe  Thr Gln Asn Ile Ala  His Ser Cys Thr Arg  Tyr Gly Leu 
    2360                 2365                 2370             


Phe Val  Tyr Pro Lys Phe Gln  Pro Pro Trp Asp Asn  Val Thr Gly 
    2375                 2380                 2385             


Thr Thr  Leu Phe Gln Ser Phe  Thr Val Trp Glu Ser  Ala Gly Gly 
    2390                 2395                 2400             


Ala Gln  Ile Phe Arg Ser Ser  Asn Leu Arg Leu Lys  Asn Phe Lys 
    2405                 2410                 2415             


Val Tyr  Ser Cys Arg Asp Phe  Gly Ile Asp Val Leu  Glu Ser Asp 
    2420                 2425                 2430             


Ala Asn  Thr Ser Val Thr Asp  Ser Leu Leu Leu Gly  His Phe Ala 
    2435                 2440                 2445             


His Lys  Gly Ser Leu Cys Met  Ser Ser Gly Ile Lys  Thr Pro Lys 
    2450                 2455                 2460             


Arg Trp  Glu Leu Met Val Ser  Asn Thr Thr Phe Val  Asn Phe Asp 
    2465                 2470                 2475             


Leu Ile  Asn Cys Val Ala Ile  Arg Thr Cys Ser Asp  Cys Ser Gln 
    2480                 2485                 2490             


Gly Gln  Gly Gly Phe Thr Val  Lys Thr Ser Gln Leu  Lys Phe Thr 
    2495                 2500                 2505             


Asn Ser  Ser Asn Leu Val Ala  Phe Pro Phe Pro His  Ala Ala Ile 
    2510                 2515                 2520             


Leu Glu  Asp Leu Asp Gly Ser  Leu Ser Gly Lys Asn  Arg Ser His 
    2525                 2530                 2535             


Ile Leu  Ala Ser Met Glu Thr  Leu Ser Ala Ser Cys  Leu Val Asn 
    2540                 2545                 2550             


Ser Ser  Phe Gly Arg Val Val  His Gly Ser Ala Cys  Gly Gly Gly 
    2555                 2560                 2565             


Val Leu  Phe His Arg Met Ser  Ile Gly Leu Ala Asn  Thr Pro Glu 
    2570                 2575                 2580             


Val Ser  Tyr Asp Leu Thr Met  Thr Asp Ser Arg Asn  Lys Thr Thr 
    2585                 2590                 2595             


Thr Val  Asn Tyr Val Arg Asp  Thr Leu Ser Asn Pro  Arg Gly Trp 
    2600                 2605                 2610             


Met Ala  Leu Leu Leu Asp Gln  Glu Thr Tyr Ser Leu  Gln Ser Glu 
    2615                 2620                 2625             


Asn Leu  Trp Ile Asn Arg Ser  Leu Gln Tyr Ser Ala  Thr Phe Asp 
    2630                 2635                 2640             


Asn Phe  Ala Pro Gly Asn Tyr  Leu Leu Leu Val His  Thr Asp Leu 
    2645                 2650                 2655             


Pro Pro  Tyr Pro Asp Ile Leu  Leu Arg Cys Gly Ser  Arg Val Gly 
    2660                 2665                 2670             


Leu Ser  Phe Pro Phe Leu Pro  Ser Pro Gly Gln Asn  Gln Gly Cys 
    2675                 2680                 2685             


Asp Trp  Phe Phe Asn Ser Gln  Leu Arg Gln Leu Thr  Tyr Leu Val 
    2690                 2695                 2700             


Ser Gly  Glu Gly Gln Val Gln  Val Ile Leu Arg Val  Lys Glu Gly 
    2705                 2710                 2715             


Met Pro  Pro Thr Ile Ser Ala  Ser Thr Ser Ala Pro  Glu Ser Ala 
    2720                 2725                 2730             


Leu Lys  Trp Ser Leu Pro Glu  Thr Trp Gln Gly Val  Glu Glu Gly 
    2735                 2740                 2745             


Trp Gly  Gly Tyr Asn Asn Thr  Ile Pro Gly Pro Gly  Asp Asp Val 
    2750                 2755                 2760             


Leu Ile  Leu Pro Asn Arg Thr  Val Leu Val Asp Thr  Asp Leu Pro 
    2765                 2770                 2775             


Phe Phe  Lys Gly Leu Tyr Val  Met Gly Thr Leu Asp  Phe Pro Val 
    2780                 2785                 2790             


Asp Arg  Ser Asn Val Leu Ser  Val Ala Cys Met Val  Ile Ala Gly 
    2795                 2800                 2805             


Gly Glu  Leu Lys Val Gly Thr  Leu Glu Asn Pro Leu  Glu Lys Glu 
    2810                 2815                 2820             


Gln Lys  Leu Leu Ile Leu Leu  Arg Ala Ser Glu Gly  Val Phe Cys 
    2825                 2830                 2835             


Asp Arg  Met Asn Gly Ile His  Ile Asp Pro Gly Thr  Ile Gly Val 
    2840                 2845                 2850             


Tyr Gly  Lys Val His Leu Tyr  Ser Ala Tyr Pro Lys  Asn Ser Trp 
    2855                 2860                 2865             


Thr His  Leu Gly Ala Asp Ile  Ala Ser Gly Asn Glu  Arg Ile Ile 
    2870                 2875                 2880             


Val Glu  Asp Ala Val Asp Trp  Arg Pro His Asp Lys  Ile Val Leu 
    2885                 2890                 2895             


Ser Ser  Ser Ser Tyr Glu Pro  His Glu Ala Glu Val  Leu Thr Val 
    2900                 2905                 2910             


Lys Glu  Val Lys Gly His His  Val Arg Ile Tyr Glu  Arg Leu Lys 
    2915                 2920                 2925             


His Arg  His Ile Gly Ser Val  His Val Thr Glu Asp  Gly Arg His 
    2930                 2935                 2940             


Ile Arg  Leu Ala Ala Glu Val  Gly Leu Leu Thr Arg  Asn Ile Gln 
    2945                 2950                 2955             


Ile Gln  Pro Asp Val Ser Cys  Arg Gly Arg Leu Phe  Val Gly Ser 
    2960                 2965                 2970             


Phe Arg  Lys Ser Ser Arg Glu  Glu Phe Ser Gly Val  Leu Gln Leu 
    2975                 2980                 2985             


Leu Asn  Val Glu Ile Gln Asn  Phe Gly Ser Pro Leu  Tyr Ser Ser 
    2990                 2995                 3000             


Val Glu  Phe Ser Asn Val Ser  Ala Gly Ser Trp Ile  Ile Ser Ser 
    3005                 3010                 3015             


Thr Leu  His Gln Ser Cys Gly  Gly Gly Ile His Ala  Ala Ala Ser 
    3020                 3025                 3030             


His Gly  Val Leu Leu Asn Asp  Asn Ile Val Phe Gly  Thr Ala Gly 
    3035                 3040                 3045             


His Gly  Ile Asp Leu Glu Gly  Gln Ala Tyr Thr Val  Thr Asn Asn 
    3050                 3055                 3060             


Leu Val  Val Leu Met Thr Gln  Pro Ala Trp Ser Thr  Ile Trp Val 
    3065                 3070                 3075             


Ala Gly  Ile Lys Val Asn Gln  Val Lys Asp Ile Asn  Leu His Gly 
    3080                 3085                 3090             


Asn Val  Val Ala Gly Ser Glu  Arg Leu Gly Phe His  Ile Arg Gly 
    3095                 3100                 3105             


His Lys  Cys Ser Ser Cys Glu  Leu Leu Trp Ser Asp  Asn Val Ala 
    3110                 3115                 3120             


His Ser  Ser Leu His Gly Leu  His Leu Tyr Lys Glu  Ser Gly Leu 
    3125                 3130                 3135             


Asp Asn  Cys Thr Arg Ile Ser  Gly Phe Leu Ala Phe  Lys Asn Phe 
    3140                 3145                 3150             


Asp Tyr  Gly Ala Met Leu His  Val Glu Asn Ser Val  Glu Ile Glu 
    3155                 3160                 3165             


Asn Ile  Thr Leu Val Asp Asn  Thr Ile Gly Leu Leu  Ala Val Val 
    3170                 3175                 3180             


Tyr Val  Phe Ser Ala Pro Gln  Asn Ser Val Lys Lys  Val Gln Ile 
    3185                 3190                 3195             


Val Leu  Arg Asn Ser Val Ile  Val Ala Thr Ser Ser  Ser Phe Asp 
    3200                 3205                 3210             


Cys Ile  Gln Asp Lys Val Lys  Pro His Ser Ala Asn  Leu Thr Ser 
    3215                 3220                 3225             


Thr Asp  Arg Ala Pro Ser Asn  Pro Arg Gly Gly Arg  Ile Gly Ile 
    3230                 3235                 3240             


Leu Trp  Pro Val Phe Thr Ser  Glu Pro Asn Gln Trp  Pro Gln Glu 
    3245                 3250                 3255             


Pro Trp  His Lys Val Arg Asn  Asp His Ser Ile Ser  Gly Ile Met 
    3260                 3265                 3270             


Lys Leu  Gln Asp Val Thr Phe  Ser Ser Phe Val Lys  Ser Cys Tyr 
    3275                 3280                 3285             


Ser Asp  Asp Leu Asp Val Cys  Ile Leu Pro Asn Ala  Glu Asn Ser 
    3290                 3295                 3300             


Gly Ile  Met His Pro Ile Thr  Ala Glu Arg Thr Arg  Met Leu Lys 
    3305                 3310                 3315             


Ile Lys  Asp Lys Asn Lys Phe  Tyr Phe Pro Ser Leu  Gln Pro Arg 
    3320                 3325                 3330             


Lys Asp  Leu Gly Lys Val Val  Cys Pro Glu Leu Asp  Cys Ala Ser 
    3335                 3340                 3345             


Pro Arg  Lys Tyr Leu Phe Lys  Asp Leu Asp Gly Arg  Ala Leu Gly 
    3350                 3355                 3360             


Leu Pro  Pro Pro Val Ser Val  Phe Pro Lys Thr Glu  Ala Glu Trp 
    3365                 3370                 3375             


Thr Ala  Ser Phe Phe Asn Ala  Val Thr Thr Glu Gln  Ala Leu Lys 
    3380                 3385                 3390             


Ile Ser  Glu 
    3395     


<210>  6251
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  6251

Met Phe His Gln Val Arg Arg Val Met Thr Ile Leu Phe Leu Thr Met 
1               5                   10                  15      


Val Ile Ser Tyr Phe Gly Cys Met Lys Ala Ala Pro Met Lys Glu Ala 
            20                  25                  30          


Asn Ile Arg Gly Gln Gly Gly Leu Ala Tyr Pro Gly Val Arg Thr His 
        35                  40                  45              


Gly Thr Leu Glu Ser Val Asn Gly Pro Lys Ala Gly Ser Arg Gly Leu 
    50                  55                  60                  


Thr Ser Leu Ala Asp Thr Phe Glu His Val Ile Glu Glu Leu Leu Asp 
65                  70                  75                  80  


Glu Asp Gln Lys Val Arg Pro Asn Glu Glu Asn Asn Lys Asp Ala Asp 
                85                  90                  95      


Leu Tyr Thr Ser Arg Val Met Leu Ser Ser Gln Val Pro Leu Glu Pro 
            100                 105                 110         


Pro Leu Leu Phe Leu Leu Glu Glu Tyr Lys Asn Tyr Leu Asp Ala Ala 
        115                 120                 125             


Asn Met Ser Met Arg Val Arg Arg His Ser Asp Pro Ala Arg Arg Gly 
    130                 135                 140                 


Glu Leu Ser Val Cys Asp Ser Ile Ser Glu Trp Val Thr Ala Ala Asp 
145                 150                 155                 160 


Lys Lys Thr Ala Val Asp Met Ser Gly Gly Thr Val Thr Val Leu Glu 
                165                 170                 175     


Lys Val Pro Val Ser Lys Gly Gln Leu Lys Gln Tyr Phe Tyr Glu Thr 
            180                 185                 190         


Lys Cys Asn Pro Met Gly Tyr Thr Lys Glu Gly Cys Arg Gly Ile Asp 
        195                 200                 205             


Lys Arg His Trp Asn Ser Gln Cys Arg Thr Thr Gln Ser Tyr Val Arg 
    210                 215                 220                 


Ala Leu Thr Met Asp Ser Lys Lys Arg Ile Gly Trp Arg Phe Ile Arg 
225                 230                 235                 240 


Ile Asp Thr Ser Cys Val Cys Thr Leu Thr Ile Lys Arg Gly Arg 
                245                 250                 255 


<210>  6252
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  6252

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  6253
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  6253

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  6254
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  6254

Met Gln Ser Arg Glu Glu Glu Trp Phe His Gln Val Arg Arg Val Met 
1               5                   10                  15      


Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met Lys 
            20                  25                  30          


Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu Ala 
        35                  40                  45              


Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly Pro 
    50                  55                  60                  


Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu His 
65                  70                  75                  80  


Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn Glu 
                85                  90                  95      


Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu Ser 
            100                 105                 110         


Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu Tyr 
        115                 120                 125             


Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg His 
    130                 135                 140                 


Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile Ser 
145                 150                 155                 160 


Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser Gly 
                165                 170                 175     


Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln Leu 
            180                 185                 190         


Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr Lys 
        195                 200                 205             


Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys Arg 
    210                 215                 220                 


Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys Arg 
225                 230                 235                 240 


Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr Leu 
                245                 250                 255     


Thr Ile Lys Arg Gly Arg 
            260         


<210>  6255
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  6255

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  6256
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  6256

Met Asp Ala Ile His Ile Gly Met Ser Ser Thr Pro Leu Val Lys His 
1               5                   10                  15      


Thr Ala Gly Ala Gly Leu Lys Ala Asn Arg Pro Arg Val Met Ser Lys 
            20                  25                  30          


Ser Gly His Ser Asn Val Arg Ile Asp Lys Val Asp Gly Ile Tyr Leu 
        35                  40                  45              


Leu Tyr Leu Gln Asp Leu Trp Thr Thr Val Ile Asp Met Lys Trp Arg 
    50                  55                  60                  


Tyr Lys Leu Thr Leu Phe Ala Ala Thr Phe Val Met Thr Trp Phe Leu 
65                  70                  75                  80  


Phe Gly Val Ile Tyr Tyr Ala Ile Ala Phe Ile His Gly Asp Leu Glu 
                85                  90                  95      


Pro Gly Glu Pro Ile Ser Asn His Thr Pro Cys Ile Met Lys Val Asp 
            100                 105                 110         


Ser Leu Thr Gly Ala Phe Leu Phe Ser Leu Glu Ser Gln Thr Thr Ile 
        115                 120                 125             


Gly Tyr Gly Val Arg Ser Ile Thr Glu Glu Cys Pro His Ala Ile Phe 
    130                 135                 140                 


Leu Leu Val Ala Gln Leu Val Ile Thr Thr Leu Ile Glu Ile Phe Ile 
145                 150                 155                 160 


Thr Gly Thr Phe Leu Ala Lys Ile Ala Arg Pro Lys Lys Arg Ala Glu 
                165                 170                 175     


Thr Ile Lys Phe Ser His Cys Ala Val Ile Thr Lys Gln Asn Gly Lys 
            180                 185                 190         


Leu Cys Leu Val Ile Gln Val Ala Asn Met Arg Lys Ser Leu Leu Ile 
        195                 200                 205             


Gln Cys Gln Leu Ser Gly Lys Leu Leu Gln Thr His Val Thr Lys Glu 
    210                 215                 220                 


Gly Glu Arg Ile Leu Leu Asn Gln Ala Thr Val Lys Phe His Val Asp 
225                 230                 235                 240 


Ser Ser Ser Glu Ser Pro Phe Leu Ile Leu Pro Met Thr Phe Tyr His 
                245                 250                 255     


Val Leu Asp Glu Thr Ser Pro Leu Arg Asp Leu Thr Pro Gln Asn Leu 
            260                 265                 270         


Lys Glu Lys Glu Phe Glu Leu Val Val Leu Leu Asn Ala Thr Val Glu 
        275                 280                 285             


Ser Thr Ser Ala Val Cys Gln Ser Arg Thr Ser Tyr Ile Pro Glu Glu 
    290                 295                 300                 


Ile Tyr Trp Gly Phe Glu Phe Val Pro Val Val Ser Leu Ser Lys Asn 
305                 310                 315                 320 


Gly Lys Tyr Val Ala Asp Phe Ser Gln Phe Glu Gln Ile Arg Lys Ser 
                325                 330                 335     


Pro Asp Cys Thr Phe Tyr Cys Ala Asp Ser Glu Lys Gln Gln Leu Glu 
            340                 345                 350         


Glu Lys Tyr Arg Gln Glu Asp Gln Arg Glu Arg Glu Leu Arg Thr Leu 
        355                 360                 365             


Leu Leu Gln Gln Ser Asn Val 
    370                 375 


<210>  6257
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  6257

Met Asp Ala Ile His Ile Gly Met Ser Ser Thr Pro Leu Val Lys His 
1               5                   10                  15      


Thr Ala Gly Ala Gly Leu Lys Ala Asn Arg Pro Arg Val Met Ser Lys 
            20                  25                  30          


Ser Gly His Ser Asn Val Arg Ile Asp Lys Val Asp Gly Ile Tyr Leu 
        35                  40                  45              


Leu Tyr Leu Gln Asp Leu Trp Thr Thr Val Ile Asp Met Lys Trp Arg 
    50                  55                  60                  


Tyr Lys Leu Thr Leu Phe Ala Ala Thr Phe Val Met Thr Trp Phe Leu 
65                  70                  75                  80  


Phe Gly Val Ile Tyr Tyr Ala Ile Ala Phe Ile His Gly Asp Leu Glu 
                85                  90                  95      


Pro Gly Glu Pro Ile Ser Asn His Thr Pro Cys Ile Met Lys Val Asp 
            100                 105                 110         


Ser Leu Thr Gly Ala Phe Leu Phe Ser Leu Glu Ser Gln Thr Thr Ile 
        115                 120                 125             


Gly Tyr Gly Val Arg Ser Ile Thr Glu Glu Cys Pro His Ala Ile Phe 
    130                 135                 140                 


Leu Leu Val Ala Gln Leu Val Ile Thr Thr Leu Ile Glu Ile Phe Ile 
145                 150                 155                 160 


Thr Gly Thr Phe Leu Ala Lys Ile Ala Arg Pro Lys Lys Arg Ala Glu 
                165                 170                 175     


Thr Ile Lys Phe Ser His Cys Ala Val Ile Thr Lys Gln Asn Gly Lys 
            180                 185                 190         


Leu Cys Leu Val Ile Gln Val Ala Asn Met Arg Lys Ser Leu Leu Ile 
        195                 200                 205             


Gln Cys Gln Leu Ser Gly Lys Leu Leu Gln Thr His Val Thr Lys Glu 
    210                 215                 220                 


Gly Glu Arg Ile Leu Leu Asn Gln Ala Thr Val Lys Phe His Val Asp 
225                 230                 235                 240 


Ser Ser Ser Glu Ser Pro Phe Leu Ile Leu Pro Met Thr Phe Tyr His 
                245                 250                 255     


Val Leu Asp Glu Thr Ser Pro Leu Arg Asp Leu Thr Pro Gln Asn Leu 
            260                 265                 270         


Lys Glu Lys Glu Phe Glu Leu Val Val Leu Leu Asn Ala Thr Val Glu 
        275                 280                 285             


Ser Thr Ser Ala Val Cys Gln Ser Arg Thr Ser Tyr Ile Pro Glu Glu 
    290                 295                 300                 


Ile Tyr Trp Gly Phe Glu Phe Val Pro Val Val Ser Leu Ser Lys Asn 
305                 310                 315                 320 


Gly Lys Tyr Val Ala Asp Phe Ser Gln Phe Glu Gln Ile Arg Lys Ser 
                325                 330                 335     


Pro Asp Cys Thr Phe Tyr Cys Ala Asp Ser Glu Lys Gln Gln Leu Glu 
            340                 345                 350         


Glu Lys Tyr Arg Gln Glu Asp Gln Arg Glu Arg Glu Leu Arg Thr Leu 
        355                 360                 365             


Leu Leu Gln Gln Ser Asn Val 
    370                 375 


<210>  6258
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  6258

Met Leu Lys Met Val Leu Thr Glu Asn Pro Asn Gln Glu Ile Ala Thr 
1               5                   10                  15      


Ser Leu Glu Phe Leu Leu Leu Gln Asn Ser Pro Gly Ser Leu Arg Ala 
            20                  25                  30          


Gln Gln Arg Met Ser Tyr Tyr Gly Ser Ser Tyr His Ile Ile Asn Ala 
        35                  40                  45              


Asp Ala Lys Tyr Pro Gly Tyr Pro Pro Glu His Ile Ile Ala Glu Lys 
    50                  55                  60                  


Arg Arg Ala Arg Arg Arg Leu Leu His Lys Asp Gly Ser Cys Asn Val 
65                  70                  75                  80  


Tyr Phe Lys His Ile Phe Gly Glu Trp Gly Ser Tyr Val Val Asp Ile 
                85                  90                  95      


Phe Thr Thr Leu Val Asp Thr Lys Trp Arg His Met Phe Val Ile Phe 
            100                 105                 110         


Ser Leu Ser Tyr Ile Leu Ser Trp Leu Ile Phe Gly Ser Val Phe Trp 
        115                 120                 125             


Leu Ile Ala Phe His His Gly Asp Leu Leu Asn Asp Pro Asp Ile Thr 
    130                 135                 140                 


Pro Cys Val Asp Asn Val His Ser Phe Thr Gly Ala Phe Leu Phe Ser 
145                 150                 155                 160 


Leu Glu Thr Gln Thr Thr Ile Gly Tyr Gly Tyr Arg Cys Val Thr Glu 
                165                 170                 175     


Glu Cys Ser Val Ala Val Leu Met Val Ile Leu Gln Ser Ile Leu Ser 
            180                 185                 190         


Cys Ile Ile Asn Thr Phe Ile Ile Gly Ala Ala Leu Ala Lys Met Ala 
        195                 200                 205             


Thr Ala Arg Lys Arg Ala Gln Thr Ile Arg Phe Ser Tyr Phe Ala Leu 
    210                 215                 220                 


Ile Gly Met Arg Asp Gly Lys Leu Cys Leu Met Trp Arg Ile Gly Asp 
225                 230                 235                 240 


Phe Arg Pro Asn His Val Val Glu Gly Thr Val Arg Ala Gln Leu Leu 
                245                 250                 255     


Arg Tyr Thr Glu Asp Ser Glu Gly Arg Met Thr Met Ala Phe Lys Asp 
            260                 265                 270         


Leu Lys Leu Val Asn Asp Gln Ile Ile Leu Val Thr Pro Val Thr Ile 
        275                 280                 285             


Val His Glu Ile Asp His Glu Ser Pro Leu Tyr Ala Leu Asp Arg Lys 
    290                 295                 300                 


Ala Val Ala Lys Asp Asn Phe Glu Ile Leu Val Thr Phe Ile Tyr Thr 
305                 310                 315                 320 


Gly Asp Ser Thr Gly Thr Ser His Gln Ser Arg Ser Ser Tyr Val Pro 
                325                 330                 335     


Arg Glu Ile Leu Trp Gly His Arg Phe Asn Asp Val Leu Glu Val Lys 
            340                 345                 350         


Arg Lys Tyr Tyr Lys Val Asn Cys Leu Gln Phe Glu Gly Ser Val Glu 
        355                 360                 365             


Val Tyr Ala Pro Phe Cys Ser Ala Lys Gln Leu Asp Trp Lys Asp Gln 
    370                 375                 380                 


Gln Leu His Ile Glu Lys Ala Pro Pro Val Arg Glu Ser Cys Thr Ser 
385                 390                 395                 400 


Asp Thr Lys Ala Arg Arg Arg Ser Phe Ser Ala Val Ala Ile Val Ser 
                405                 410                 415     


Ser Cys Glu Asn Pro Glu Glu Thr Thr Thr Ser Ala Thr His Glu Tyr 
            420                 425                 430         


Arg Glu Thr Pro Tyr Gln Lys Ala Leu Leu Thr Leu Asn Arg Ile Ser 
        435                 440                 445             


Val Glu Ser Gln Met 
    450             


<210>  6259
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  6259

Met Leu Lys Met Val Leu Thr Glu Asn Pro Asn Gln Glu Ile Ala Thr 
1               5                   10                  15      


Ser Leu Glu Phe Leu Leu Leu Gln Asn Ser Pro Gly Ser Leu Arg Ala 
            20                  25                  30          


Gln Gln Arg Met Ser Tyr Tyr Gly Ser Ser Tyr His Ile Ile Asn Ala 
        35                  40                  45              


Asp Ala Lys Tyr Pro Gly Tyr Pro Pro Glu His Ile Ile Ala Glu Lys 
    50                  55                  60                  


Arg Arg Ala Arg Arg Arg Leu Leu His Lys Asp Gly Ser Cys Asn Val 
65                  70                  75                  80  


Tyr Phe Lys His Ile Phe Gly Glu Trp Gly Ser Tyr Val Val Asp Ile 
                85                  90                  95      


Phe Thr Thr Leu Val Asp Thr Lys Trp Arg His Met Phe Val Ile Phe 
            100                 105                 110         


Ser Leu Ser Tyr Ile Leu Ser Trp Leu Ile Phe Gly Ser Val Phe Trp 
        115                 120                 125             


Leu Ile Ala Phe His His Gly Asp Leu Leu Asn Asp Pro Asp Ile Thr 
    130                 135                 140                 


Pro Cys Val Asp Asn Val His Ser Phe Thr Gly Ala Phe Leu Phe Ser 
145                 150                 155                 160 


Leu Glu Thr Gln Thr Thr Ile Gly Tyr Gly Tyr Arg Cys Val Thr Glu 
                165                 170                 175     


Glu Cys Ser Val Ala Val Leu Met Val Ile Leu Gln Ser Ile Leu Ser 
            180                 185                 190         


Cys Ile Ile Asn Thr Phe Ile Ile Gly Ala Ala Leu Ala Lys Met Ala 
        195                 200                 205             


Thr Ala Arg Lys Arg Ala Gln Thr Ile Arg Phe Ser Tyr Phe Ala Leu 
    210                 215                 220                 


Ile Gly Met Arg Asp Gly Lys Leu Cys Leu Met Trp Arg Ile Gly Asp 
225                 230                 235                 240 


Phe Arg Pro Asn His Val Val Glu Gly Thr Val Arg Ala Gln Leu Leu 
                245                 250                 255     


Arg Tyr Thr Glu Asp Ser Glu Gly Arg Met Thr Met Ala Phe Lys Asp 
            260                 265                 270         


Leu Lys Leu Val Asn Asp Gln Ile Ile Leu Val Thr Pro Val Thr Ile 
        275                 280                 285             


Val His Glu Ile Asp His Glu Ser Pro Leu Tyr Ala Leu Asp Arg Lys 
    290                 295                 300                 


Ala Val Ala Lys Asp Asn Phe Glu Ile Leu Val Thr Phe Ile Tyr Thr 
305                 310                 315                 320 


Gly Asp Ser Thr Gly Thr Ser His Gln Ser Arg Ser Ser Tyr Val Pro 
                325                 330                 335     


Arg Glu Ile Leu Trp Gly His Arg Phe Asn Asp Val Leu Glu Val Lys 
            340                 345                 350         


Arg Lys Tyr Tyr Lys Val Asn Cys Leu Gln Phe Glu Gly Ser Val Glu 
        355                 360                 365             


Val Tyr Ala Pro Phe Cys Ser Ala Lys Gln Leu Asp Trp Lys Asp Gln 
    370                 375                 380                 


Gln Leu His Ile Glu Lys Ala Pro Pro Val Arg Glu Ser Cys Thr Ser 
385                 390                 395                 400 


Asp Thr Lys Ala Arg Arg Arg Ser Phe Ser Ala Val Ala Ile Val Ser 
                405                 410                 415     


Ser Cys Glu Asn Pro Glu Glu Thr Thr Thr Ser Ala Thr His Glu Tyr 
            420                 425                 430         


Arg Glu Thr Pro Tyr Gln Lys Ala Leu Leu Thr Leu Asn Arg Ile Ser 
        435                 440                 445             


Val Glu Ser Gln Met 
    450             


<210>  6260
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  6260

Met Ala Gly Pro Glu Arg Trp Gly Pro Leu Leu Leu Cys Leu Leu Gln 
1               5                   10                  15      


Ala Ala Pro Gly Arg Pro Arg Leu Ala Pro Pro Gln Asn Val Thr Leu 
            20                  25                  30          


Leu Ser Gln Asn Phe Ser Val Tyr Leu Thr Trp Leu Pro Gly Leu Gly 
        35                  40                  45              


Asn Pro Gln Asp Val Thr Tyr Phe Val Ala Tyr Gln Ser Ser Pro Thr 
    50                  55                  60                  


Arg Arg Arg Trp Arg Glu Val Glu Glu Cys Ala Gly Thr Lys Glu Leu 
65                  70                  75                  80  


Leu Cys Ser Met Met Cys Leu Lys Lys Gln Asp Leu Tyr Asn Lys Phe 
                85                  90                  95      


Lys Gly Arg Val Arg Thr Val Ser Pro Ser Ser Lys Ser Pro Trp Val 
            100                 105                 110         


Glu Ser Glu Tyr Leu Asp Tyr Leu Phe Glu Val Glu Pro Ala Pro Pro 
        115                 120                 125             


Val Leu Val Leu Thr Gln Thr Glu Glu Ile Leu Ser Ala Asn Ala Thr 
    130                 135                 140                 


Tyr Gln Leu Pro Pro Cys Met Pro Pro Leu Asp Leu Lys Tyr Glu Val 
145                 150                 155                 160 


Ala Phe Trp Lys Glu Gly Ala Gly Asn Lys Thr Leu Phe Pro Val Thr 
                165                 170                 175     


Pro His Gly Gln Pro Val Gln Ile Thr Leu Gln Pro Ala Ala Ser Glu 
            180                 185                 190         


His His Cys Leu Ser Ala Arg Thr Ile Tyr Thr Phe Ser Val Pro Lys 
        195                 200                 205             


Tyr Ser Lys Phe Ser Lys Pro Thr Cys Phe Leu Leu Glu Val Pro Glu 
    210                 215                 220                 


Ala Asn Trp Ala Phe Leu Val Leu Pro Ser Leu Leu Ile Leu Leu Leu 
225                 230                 235                 240 


Val Ile Ala Ala Gly Gly Val Ile Trp Lys Thr Leu Met Gly Asn Pro 
                245                 250                 255     


Trp Phe Gln Arg Ala Lys Met Pro Arg Ala Leu Asp Phe Ser Gly His 
            260                 265                 270         


Thr His Pro Val Ala Thr Phe Gln Pro Ser Arg Pro Glu Ser Val Asn 
        275                 280                 285             


Asp Leu Phe Leu Cys Pro Gln Lys Glu Leu Thr Arg Gly Val Arg Pro 
    290                 295                 300                 


Thr Pro Arg Val Arg Ala Pro Ala Thr Gln Gln Thr Arg Trp Lys Lys 
305                 310                 315                 320 


Asp Leu Ala Glu Asp Glu Glu Glu Glu Asp Glu Glu Asp Thr Glu Asp 
                325                 330                 335     


Gly Val Ser Phe Gln Pro Tyr Ile Glu Pro Pro Ser Phe Leu Gly Gln 
            340                 345                 350         


Glu His Gln Ala Pro Gly His Ser Glu Ala Gly Gly Val Asp Ser Gly 
        355                 360                 365             


Arg Pro Arg Ala Pro Leu Val Pro Ser Glu Gly Ser Ser Ala Trp Asp 
    370                 375                 380                 


Ser Ser Asp Arg Ser Trp Ala Ser Thr Val Asp Ser Ser Trp Asp Arg 
385                 390                 395                 400 


Ala Gly Ser Ser Gly Tyr Leu Ala Glu Lys Gly Pro Gly Gln Gly Pro 
                405                 410                 415     


Gly Gly Asp Gly His Gln Glu Ser Leu Pro Pro Pro Glu Phe Ser Lys 
            420                 425                 430         


Asp Ser Gly Phe Leu Glu Glu Leu Pro Glu Asp Asn Leu Ser Ser Trp 
        435                 440                 445             


Ala Thr Trp Gly Thr Leu Pro Pro Glu Pro Asn Leu Val Pro Gly Gly 
    450                 455                 460                 


Pro Pro Val Ser Leu Gln Thr Leu Thr Phe Cys Trp Glu Ser Ser Pro 
465                 470                 475                 480 


Glu Glu Glu Glu Glu Ala Arg Glu Ser Glu Ile Glu Asp Ser Asp Ala 
                485                 490                 495     


Gly Ser Trp Gly Ala Glu Ser Thr Gln Arg Thr Glu Asp Arg Gly Arg 
            500                 505                 510         


Thr Leu Gly His Tyr Met Ala Arg 
        515                 520 


<210>  6261
<211>  945
<212>  PRT
<213>  Homo sapiens

<400>  6261

Met Gly Ala Arg Ser Gly Ala Arg Gly Ala Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Leu Cys Trp Asp Pro Arg Leu Ser Gln Ala Gly Thr Asp Ser Gly Ser 
            20                  25                  30          


Glu Val Leu Pro Asp Ser Phe Pro Ser Ala Pro Ala Glu Pro Leu Pro 
        35                  40                  45              


Tyr Phe Leu Gln Glu Pro Gln Asp Ala Tyr Ile Val Lys Asn Lys Pro 
    50                  55                  60                  


Val Glu Leu Arg Cys Arg Ala Phe Pro Ala Thr Gln Ile Tyr Phe Lys 
65                  70                  75                  80  


Cys Asn Gly Glu Trp Val Ser Gln Asn Asp His Val Thr Gln Glu Gly 
                85                  90                  95      


Leu Asp Glu Ala Thr Gly Leu Arg Val Arg Glu Val Gln Ile Glu Val 
            100                 105                 110         


Ser Arg Gln Gln Val Glu Glu Leu Phe Gly Leu Glu Asp Tyr Trp Cys 
        115                 120                 125             


Gln Cys Val Ala Trp Ser Ser Ala Gly Thr Thr Lys Ser Arg Arg Ala 
    130                 135                 140                 


Tyr Val Arg Ile Ala Tyr Leu Arg Lys Asn Phe Asp Gln Glu Pro Leu 
145                 150                 155                 160 


Gly Lys Glu Val Pro Leu Asp His Glu Val Leu Leu Gln Cys Arg Pro 
                165                 170                 175     


Pro Glu Gly Val Pro Val Ala Glu Val Glu Trp Leu Lys Asn Glu Asp 
            180                 185                 190         


Val Ile Asp Pro Thr Gln Asp Thr Asn Phe Leu Leu Thr Ile Asp His 
        195                 200                 205             


Asn Leu Ile Ile Arg Gln Ala Arg Leu Ser Asp Thr Ala Asn Tyr Thr 
    210                 215                 220                 


Cys Val Ala Lys Asn Ile Val Ala Lys Arg Arg Ser Thr Thr Ala Thr 
225                 230                 235                 240 


Val Ile Val Tyr Val Asn Gly Gly Trp Ser Ser Trp Ala Glu Trp Ser 
                245                 250                 255     


Pro Cys Ser Asn Arg Cys Gly Arg Gly Trp Gln Lys Arg Thr Arg Thr 
            260                 265                 270         


Cys Thr Asn Pro Ala Pro Leu Asn Gly Gly Ala Phe Cys Glu Gly Gln 
        275                 280                 285             


Ala Phe Gln Lys Thr Ala Cys Thr Thr Ile Cys Pro Val Asp Gly Ala 
    290                 295                 300                 


Trp Thr Glu Trp Ser Lys Trp Ser Ala Cys Ser Thr Glu Cys Ala His 
305                 310                 315                 320 


Trp Arg Ser Arg Glu Cys Met Ala Pro Pro Pro Gln Asn Gly Gly Arg 
                325                 330                 335     


Asp Cys Ser Gly Thr Leu Leu Asp Ser Lys Asn Cys Thr Asp Gly Leu 
            340                 345                 350         


Cys Met Gln Asn Lys Lys Thr Leu Ser Asp Pro Asn Ser His Leu Leu 
        355                 360                 365             


Glu Ala Ser Gly Asp Ala Ala Leu Tyr Ala Gly Leu Val Val Ala Ile 
    370                 375                 380                 


Phe Val Val Val Ala Ile Leu Met Ala Val Gly Val Val Val Tyr Arg 
385                 390                 395                 400 


Arg Asn Cys Arg Asp Phe Asp Thr Asp Ile Thr Asp Ser Ser Ala Ala 
                405                 410                 415     


Leu Thr Gly Gly Phe His Pro Val Asn Phe Lys Thr Ala Arg Pro Ser 
            420                 425                 430         


Asn Pro Gln Leu Leu His Pro Ser Val Pro Pro Asp Leu Thr Ala Ser 
        435                 440                 445             


Ala Gly Ile Tyr Arg Gly Pro Val Tyr Ala Leu Gln Asp Ser Thr Asp 
    450                 455                 460                 


Lys Ile Pro Met Thr Asn Ser Pro Leu Leu Asp Pro Leu Pro Ser Leu 
465                 470                 475                 480 


Lys Val Lys Val Tyr Ser Ser Ser Thr Thr Gly Ser Gly Pro Gly Leu 
                485                 490                 495     


Ala Asp Gly Ala Asp Leu Leu Gly Val Leu Pro Pro Gly Thr Tyr Pro 
            500                 505                 510         


Ser Asp Phe Ala Arg Asp Thr His Phe Leu His Leu Arg Ser Ala Ser 
        515                 520                 525             


Leu Gly Ser Gln Gln Leu Leu Gly Leu Pro Arg Asp Pro Gly Ser Ser 
    530                 535                 540                 


Val Ser Gly Thr Phe Gly Cys Leu Gly Gly Arg Leu Ser Ile Pro Gly 
545                 550                 555                 560 


Thr Gly Val Ser Leu Leu Val Pro Asn Gly Ala Ile Pro Gln Gly Lys 
                565                 570                 575     


Phe Tyr Glu Met Tyr Leu Leu Ile Asn Lys Ala Glu Ser Thr Leu Pro 
            580                 585                 590         


Leu Ser Glu Gly Thr Gln Thr Val Leu Ser Pro Ser Val Thr Cys Gly 
        595                 600                 605             


Pro Thr Gly Leu Leu Leu Cys Arg Pro Val Ile Leu Thr Met Pro His 
    610                 615                 620                 


Cys Ala Glu Val Ser Ala Arg Asp Trp Ile Phe Gln Leu Lys Thr Gln 
625                 630                 635                 640 


Ala His Gln Gly His Trp Glu Glu Val Val Thr Leu Asp Glu Glu Thr 
                645                 650                 655     


Leu Asn Thr Pro Cys Tyr Cys Gln Leu Glu Pro Arg Ala Cys His Ile 
            660                 665                 670         


Leu Leu Asp Gln Leu Gly Thr Tyr Val Phe Thr Gly Glu Ser Tyr Ser 
        675                 680                 685             


Arg Ser Ala Val Lys Arg Leu Gln Leu Ala Val Phe Ala Pro Ala Leu 
    690                 695                 700                 


Cys Thr Ser Leu Glu Tyr Ser Leu Arg Val Tyr Cys Leu Glu Asp Thr 
705                 710                 715                 720 


Pro Val Ala Leu Lys Glu Val Leu Glu Leu Glu Arg Thr Leu Gly Gly 
                725                 730                 735     


Tyr Leu Val Glu Glu Pro Lys Pro Leu Met Phe Lys Asp Ser Tyr His 
            740                 745                 750         


Asn Leu Arg Leu Ser Leu His Asp Leu Pro His Ala His Trp Arg Ser 
        755                 760                 765             


Lys Leu Leu Ala Lys Tyr Gln Glu Ile Pro Phe Tyr His Ile Trp Ser 
    770                 775                 780                 


Gly Ser Gln Lys Ala Leu His Cys Thr Phe Thr Leu Glu Arg His Ser 
785                 790                 795                 800 


Leu Ala Ser Thr Glu Leu Thr Cys Lys Ile Cys Val Arg Gln Val Glu 
                805                 810                 815     


Gly Glu Gly Gln Ile Phe Gln Leu His Thr Thr Leu Ala Glu Thr Pro 
            820                 825                 830         


Ala Gly Ser Leu Asp Thr Leu Cys Ser Ala Pro Gly Ser Thr Val Thr 
        835                 840                 845             


Thr Gln Leu Gly Pro Tyr Ala Phe Lys Ile Pro Leu Ser Ile Arg Gln 
    850                 855                 860                 


Lys Ile Cys Asn Ser Leu Asp Ala Pro Asn Ser Arg Gly Asn Asp Trp 
865                 870                 875                 880 


Arg Met Leu Ala Gln Lys Leu Ser Met Asp Arg Tyr Leu Asn Tyr Phe 
                885                 890                 895     


Ala Thr Lys Ala Ser Pro Thr Gly Val Ile Leu Asp Leu Trp Glu Ala 
            900                 905                 910         


Leu Gln Gln Asp Asp Gly Asp Leu Asn Ser Leu Ala Ser Ala Leu Glu 
        915                 920                 925             


Glu Met Gly Lys Ser Glu Met Leu Val Ala Val Ala Thr Asp Gly Asp 
    930                 935                 940                 


Cys 
945 


<210>  6262
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  6262

Met Trp Leu Ile Ser Ile Thr Phe Leu Ser Ile Gly Tyr Gly Asp Met 
1               5                   10                  15      


Val Pro Asn Thr Tyr Cys Gly Lys Gly Val Cys Leu Leu Thr Gly Ile 
            20                  25                  30          


Met Gly Ala Gly Cys Thr Ala Leu Val Val Ala Val Val Ala Arg Lys 
        35                  40                  45              


Leu Glu Leu Thr Lys Ala Glu Lys His Val His Asn Phe Met Met Asp 
    50                  55                  60                  


Thr Gln Leu Thr Lys Arg Val Lys Asn Ala Ala Ala Asn Val Leu Arg 
65                  70                  75                  80  


Glu Thr Trp Leu Ile Tyr Lys Asn Thr Lys Leu Val Lys Lys Ile Asp 
                85                  90                  95      


His Ala Lys Val Arg Lys His Gln Arg Lys Phe Leu Gln Ala Ile His 
            100                 105                 110         


Gln Leu Arg Ser Val Lys Met Glu Gln Arg Lys Leu Asn Asp Gln Ala 
        115                 120                 125             


Asn Thr Leu Val Asp Leu Ala Lys Thr Gln Asn Ile Met Tyr Asp Met 
    130                 135                 140                 


Ile Ser Asp Leu Asn Glu Arg Ser Glu Asp Phe Glu Lys Arg Ile Val 
145                 150                 155                 160 


Thr Leu Glu Thr Lys Leu Glu Thr Leu Ile Gly Ser Ile His Ala Leu 
                165                 170                 175     


Pro Gly Leu Ile Ser Gln Thr Ile Arg Gln Gln Gln Arg Asp Phe Ile 
            180                 185                 190         


Glu Ala Gln Met Glu Ser Tyr Asp Lys His Val Thr Tyr Asn Ala Glu 
        195                 200                 205             


Arg Ser Arg Ser Ser Ser Arg Arg Arg Arg Ser Ser Ser Thr Ala Pro 
    210                 215                 220                 


Pro Thr Ser Ser Glu Ser Ser 
225                 230     


<210>  6263
<211>  549
<212>  PRT
<213>  Homo sapiens

<400>  6263

Met Ala Thr Pro Arg Gly Leu Gly Ala Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Pro Thr Ser Gly Gln Glu Lys Pro Thr Glu Gly Pro Arg Asn Thr Cys 
            20                  25                  30          


Leu Gly Ser Asn Asn Met Tyr Asp Ile Phe Asn Leu Asn Asp Lys Ala 
        35                  40                  45              


Leu Cys Phe Thr Lys Cys Arg Gln Ser Gly Ser Asp Ser Cys Asn Val 
    50                  55                  60                  


Glu Asn Leu Gln Arg Tyr Trp Leu Asn Tyr Glu Ala His Leu Met Lys 
65                  70                  75                  80  


Glu Gly Leu Thr Gln Lys Val Asn Thr Pro Phe Leu Lys Ala Leu Val 
                85                  90                  95      


Gln Asn Leu Ser Thr Asn Thr Ala Glu Asp Phe Tyr Phe Ser Leu Glu 
            100                 105                 110         


Pro Ser Gln Val Pro Arg Gln Val Met Lys Asp Glu Asp Lys Pro Pro 
        115                 120                 125             


Asp Arg Val Arg Leu Pro Lys Ser Leu Phe Arg Ser Leu Pro Gly Asn 
    130                 135                 140                 


Arg Ser Val Val Arg Leu Ala Val Thr Ile Leu Asp Ile Gly Pro Gly 
145                 150                 155                 160 


Thr Leu Phe Lys Gly Pro Arg Leu Gly Leu Gly Asp Gly Ser Gly Val 
                165                 170                 175     


Leu Asn Asn Arg Leu Val Gly Leu Ser Val Gly Gln Met His Val Thr 
            180                 185                 190         


Lys Leu Ala Glu Pro Leu Glu Ile Val Phe Ser His Gln Arg Pro Pro 
        195                 200                 205             


Pro Asn Met Thr Leu Thr Cys Val Phe Trp Asp Val Thr Lys Gly Thr 
    210                 215                 220                 


Thr Gly Asp Trp Ser Ser Glu Gly Cys Ser Thr Glu Val Arg Pro Glu 
225                 230                 235                 240 


Gly Thr Val Cys Cys Cys Asp His Leu Thr Phe Phe Ala Leu Leu Leu 
                245                 250                 255     


Arg Pro Thr Leu Asp Gln Ser Thr Val His Ile Leu Thr Arg Ile Ser 
            260                 265                 270         


Gln Ala Gly Cys Gly Val Ser Met Ile Phe Leu Ala Phe Thr Ile Ile 
        275                 280                 285             


Leu Tyr Ala Phe Leu Arg Leu Ser Arg Glu Arg Phe Lys Ser Glu Asp 
    290                 295                 300                 


Ala Pro Lys Ile His Val Ala Leu Gly Gly Ser Leu Phe Leu Leu Asn 
305                 310                 315                 320 


Leu Ala Phe Leu Val Asn Val Gly Ser Gly Ser Lys Gly Ser Asp Ala 
                325                 330                 335     


Ala Cys Trp Ala Arg Gly Ala Val Phe His Tyr Phe Leu Leu Cys Ala 
            340                 345                 350         


Phe Thr Trp Met Gly Leu Glu Ala Phe His Leu Tyr Leu Leu Ala Val 
        355                 360                 365             


Arg Val Phe Asn Thr Tyr Phe Gly His Tyr Phe Leu Lys Leu Ser Leu 
    370                 375                 380                 


Val Gly Trp Gly Leu Pro Ala Leu Met Val Ile Gly Thr Gly Ser Ala 
385                 390                 395                 400 


Asn Ser Tyr Gly Leu Tyr Thr Ile Arg Asp Arg Glu Asn Arg Thr Ser 
                405                 410                 415     


Leu Glu Leu Cys Trp Phe Arg Glu Gly Thr Thr Met Tyr Ala Leu Tyr 
            420                 425                 430         


Ile Thr Val His Gly Tyr Phe Leu Ile Thr Phe Leu Phe Gly Met Val 
        435                 440                 445             


Val Leu Ala Leu Val Val Trp Lys Ile Phe Thr Leu Ser Arg Ala Thr 
    450                 455                 460                 


Ala Val Lys Glu Arg Gly Lys Asn Arg Lys Lys Val Leu Thr Leu Leu 
465                 470                 475                 480 


Gly Leu Ser Ser Leu Val Gly Val Thr Trp Gly Leu Ala Ile Phe Thr 
                485                 490                 495     


Pro Leu Gly Leu Ser Thr Val Tyr Ile Phe Ala Leu Phe Asn Ser Leu 
            500                 505                 510         


Gln Gly Val Phe Ile Cys Cys Trp Phe Thr Ile Leu Tyr Leu Pro Ser 
        515                 520                 525             


Gln Ser Thr Thr Val Ser Ser Ser Thr Ala Arg Leu Asp Gln Ala His 
    530                 535                 540                 


Ser Ala Ser Gln Glu 
545                 


<210>  6264
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  6264

Met Leu Cys Pro Trp Arg Thr Ala Asn Leu Gly Leu Leu Leu Ile Leu 
1               5                   10                  15      


Thr Ile Phe Leu Val Ala Ala Ser Ser Ser Leu Cys Met Asp Glu Lys 
            20                  25                  30          


Gln Ile Thr Gln Asn Tyr Ser Lys Val Leu Ala Glu Val Asn Thr Ser 
        35                  40                  45              


Trp Pro Val Lys Met Ala Thr Asn Ala Val Leu Cys Cys Pro Pro Ile 
    50                  55                  60                  


Ala Leu Arg Asn Leu Ile Ile Ile Thr Trp Glu Ile Ile Leu Arg Gly 
65                  70                  75                  80  


Gln Pro Ser Cys Thr Lys Ala Tyr Lys Lys Glu Thr Asn Glu Thr Lys 
                85                  90                  95      


Glu Thr Asn Cys Thr Asp Glu Arg Ile Thr Trp Val Ser Arg Pro Asp 
            100                 105                 110         


Gln Asn Ser Asp Leu Gln Ile Arg Thr Val Ala Ile Thr His Asp Gly 
        115                 120                 125             


Tyr Tyr Arg Cys Ile Met Val Thr Pro Asp Gly Asn Phe His Arg Gly 
    130                 135                 140                 


Tyr His Leu Gln Val Leu Val Thr Pro Glu Val Thr Leu Phe Gln Asn 
145                 150                 155                 160 


Arg Asn Arg Thr Ala Val Cys Lys Ala Val Ala Gly Lys Pro Ala Ala 
                165                 170                 175     


His Ile Ser Trp Ile Pro Glu Gly Asp Cys Ala Thr Lys Gln Glu Tyr 
            180                 185                 190         


Trp Ser Asn Gly Thr Val Thr Val Lys Ser Thr Cys His Trp Glu Val 
        195                 200                 205             


His Asn Val Ser Thr Val Thr Cys His Val Ser His Leu Thr Gly Asn 
    210                 215                 220                 


Lys Ser Leu Tyr Ile Glu Leu Leu Pro Val Pro Gly Ala Lys Lys Ser 
225                 230                 235                 240 


Ala Lys Leu Tyr Ile Pro Tyr Ile Ile Leu Thr Ile Ile Ile Leu Thr 
                245                 250                 255     


Ile Val Gly Phe Ile Trp Leu Leu Lys Val Asn Gly Cys Arg Lys Tyr 
            260                 265                 270         


Lys Leu Asn Lys Thr Glu Ser Thr Pro Val Val Glu Glu Asp Glu Met 
        275                 280                 285             


Gln Pro Tyr Ala Ser Tyr Thr Glu Lys Asn Asn Pro Leu Tyr Asp Thr 
    290                 295                 300                 


Thr Asn Lys Val Lys Ala Ser Glu Ala Leu Gln Ser Glu Val Asp Thr 
305                 310                 315                 320 


Asp Leu His Thr Leu 
                325 


<210>  6265
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  6265

Met Glu Arg Pro Ile Lys Asp Ser Met Phe Ser Leu Ala Leu Lys Cys 
1               5                   10                  15      


Leu Ile Ser Leu Ser Thr Ile Ile Leu Leu Gly Leu Ile Ile Ala Tyr 
            20                  25                  30          


His Thr Arg Glu Val Gln Leu Phe Val Ile Asp Asn Gly Ala Asp Asp 
        35                  40                  45              


Trp Arg Ile Ala Met Thr Tyr Glu Arg Ile Leu Tyr Ile Ser Leu Glu 
    50                  55                  60                  


Met Leu Val Cys Ala Ile His Pro Ile Pro Gly Glu Tyr Lys Phe Phe 
65                  70                  75                  80  


Trp Thr Ala Arg Leu Ala Phe Ser Tyr Thr Pro Ser Arg Ala Glu Ala 
                85                  90                  95      


Asp Val Asp Ile Ile Leu Ser Ile Pro Met Phe Leu Arg Leu Tyr Leu 
            100                 105                 110         


Ile Ala Arg Val Met Leu Leu His Ser Lys Leu Phe Thr Asp Ala Ser 
        115                 120                 125             


Ser Arg Ser Ile Gly Ala Leu Asn Lys Ile Asn Phe Asn Thr Arg Phe 
    130                 135                 140                 


Val Met Lys Thr Leu Met Thr Ile Cys Pro Gly Thr Val Leu Leu Val 
145                 150                 155                 160 


Phe Ser Ile Ser Leu Trp Ile Ile Ala Ala Trp Thr Val Arg Val Cys 
                165                 170                 175     


Glu Arg Tyr His Asp Gln Gln Asp Val Thr Ser Asn Phe Leu Gly Ala 
            180                 185                 190         


Met Trp Leu Ile Ser Ile Thr Phe Leu Ser Ile Gly Tyr Gly Asp Met 
        195                 200                 205             


Val Pro His Thr Tyr Cys Gly Lys Gly Val Cys Leu Leu Thr Gly Ile 
    210                 215                 220                 


Met Gly Ala Gly Cys Thr Ala Leu Val Val Ala Val Val Ala Arg Lys 
225                 230                 235                 240 


Leu Glu Leu Thr Lys Ala Glu Lys His Val His Asn Phe Met Met Asp 
                245                 250                 255     


Thr Gln Leu Thr Lys Arg Ile Lys Asn Ala Ala Ala Asn Val Leu Arg 
            260                 265                 270         


Glu Thr Trp Leu Ile Tyr Lys His Thr Lys Leu Leu Lys Lys Ile Asp 
        275                 280                 285             


His Ala Lys Val Arg Lys His Gln Arg Lys Phe Leu Gln Ala Ile His 
    290                 295                 300                 


Gln Leu Arg Ser Val Lys Met Glu Gln Arg Lys Leu Ser Asp Gln Ala 
305                 310                 315                 320 


Asn Thr Leu Val Asp Leu Ser Lys Met Gln Asn Val Met Tyr Asp Leu 
                325                 330                 335     


Ile Thr Glu Leu Asn Asp Arg Ser Glu Asp Leu Glu Lys Gln Ile Gly 
            340                 345                 350         


Ser Leu Glu Ser Lys Leu Glu His Leu Thr Ala Ser Phe Asn Ser Leu 
        355                 360                 365             


Pro Leu Leu Ile Ala Asp Thr Leu Arg Gln Gln Gln Gln Gln Leu Leu 
    370                 375                 380                 


Ser Ala Ile Ile Glu Ala Arg Gly Val Ser Val Ala Val Gly Thr Thr 
385                 390                 395                 400 


His Thr Pro Ile Ser Asp Ser Pro Ile Gly Val Ser Ser Thr Ser Phe 
                405                 410                 415     


Pro Thr Pro Tyr Thr Ser Ser Ser Ser Cys 
            420                 425     


<210>  6266
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  6266

Met Ile Leu Lys Gly Cys Leu Leu Tyr Pro Leu Cys Ser Pro Arg Asn 
1               5                   10                  15      


Lys Gln Arg Cys Ala Arg Leu Trp Lys Ile Ala Tyr Gly Gly Leu Leu 
            20                  25                  30          


Lys Ile Val Thr Gly Ser Leu Leu Thr Phe Tyr Val Val Leu Cys Leu 
        35                  40                  45              


Asp Gly Gly Met Val Leu Met Arg Lys Gln Val Pro Ser Arg Phe Met 
    50                  55                  60                  


Tyr Pro Lys Glu Trp Gln His Leu Thr Met Phe Ile Leu Leu Thr Leu 
65                  70                  75                  80  


Asn Gly Cys Val Asp Phe Met Ser Lys Asn Val Leu Pro Gln Arg Cys 
                85                  90                  95      


Val Gly Leu Glu Lys Gly Thr Leu Val Leu Ile Ile Tyr Glu Leu Leu 
            100                 105                 110         


Leu Leu Met Val Ser His Val Lys Asp Ser Glu Gly Val Glu Leu His 
        115                 120                 125             


Val Tyr Ser Leu Leu Ile Leu Val Val Phe Leu Leu Leu Leu Val Leu 
    130                 135                 140                 


Thr Ala Glu Leu Trp Ala Pro Asn Met Cys His Leu Gln Leu Met Glu 
145                 150                 155                 160 


Thr Phe Leu Ile Leu Met Met Gly Ser Trp Leu Met Gln Ala Gly Phe 
                165                 170                 175     


Ile Leu Tyr Arg Pro Val Ser Gly Tyr Pro Trp Gln Asp Asp Asp Ile 
            180                 185                 190         


Ser Asp Ile Met Phe Val Thr Thr Phe Phe Cys Trp His Val Met Ile 
        195                 200                 205             


Asn Ala Ser Phe Leu Leu Gly Ile Tyr Gly Phe Ser Ser Phe Trp Tyr 
    210                 215                 220                 


His Cys Phe Arg Pro Ser Leu Lys Leu Thr Gly Pro Lys Glu Ala Pro 
225                 230                 235                 240 


Tyr Tyr Ala Ser Thr Pro Gly Pro Leu Tyr Lys Leu Leu Gln Glu Val 
                245                 250                 255     


Glu Gln Ser Glu Lys Glu Asp Gln Ala Leu Leu Leu Pro Lys Ser Ser 
            260                 265                 270         


Pro 
    


<210>  6267
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  6267

Met Val Ser Asn Phe Phe His Val Ile Gln Val Phe Glu Lys Ser Ala 
1               5                   10                  15      


Thr Leu Ile Ser Lys Thr Glu His Ile Gly Phe Val Ile Tyr Ser Trp 
            20                  25                  30          


Arg Lys Ser Thr Thr His Leu Gly Ser Arg Arg Lys Phe Ala Ile Ser 
        35                  40                  45              


Ile Tyr Leu Ser Glu Val Ser Leu Gln Lys Tyr Asp Cys Pro Phe Ser 
    50                  55                  60                  


Gly Thr Ser Phe Val Val Phe Ser Leu Phe Leu Ile Cys Ala Met Ala 
65                  70                  75                  80  


Gly Asp Val Val Tyr Ala Asp Ile Lys Thr Val Arg Thr Ser Pro Leu 
                85                  90                  95      


Glu Leu Ala Phe Pro Leu Gln Arg Ser Val Ser Phe Asn Phe Ser Thr 
            100                 105                 110         


Val His Lys Ser Cys Pro Ala Lys Asp Trp Lys Val His Lys Gly Lys 
        115                 120                 125             


Cys Tyr Trp Ile Ala Glu Thr Lys Lys Ser Trp Asn Lys Ser Gln Asn 
    130                 135                 140                 


Asp Cys Ala Ile Asn Asn Ser Tyr Leu Met Val Ile Gln Asp Ile Thr 
145                 150                 155                 160 


Ala Met Val Arg Phe Asn Ile 
                165         


<210>  6268
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  6268

Met Ala Pro Gln Thr Leu Leu Leu Val Leu Val Leu Cys Val Leu Leu 
1               5                   10                  15      


Leu Gln Ala Gln Gly Gly Tyr Arg Asp Lys Met Arg Met Gln Arg Ile 
            20                  25                  30          


Lys Val Cys Glu Lys Arg Pro Ser Ile Asp Leu Cys Ile His His Cys 
        35                  40                  45              


Ser Tyr Phe Gln Lys Cys Glu Thr Asn Lys Ile Cys Cys Ser Ala Phe 
    50                  55                  60                  


Cys Gly Asn Ile Cys Met Ser Ile Leu 
65                  70              


<210>  6269
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  6269

Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 
1               5                   10                  15      


Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 
            20                  25                  30          


Cys Ser Val Ala Arg Asp Gly Pro Ala Gly Ser Trp Glu Gln Leu Ile 
        35                  40                  45              


Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala His Leu Thr Gly 
    50                  55                  60                  


Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr 
65                  70                  75                  80  


Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala 
                85                  90                  95      


Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln 
            100                 105                 110         


Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His 
        115                 120                 125             


Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu 
    130                 135                 140                 


Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val 
145                 150                 155                 160 


Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly 
                165                 170                 175     


Glu Lys Val Val Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg 
            180                 185                 190         


Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
        195                 200                 


<210>  6270
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  6270

Met Asn Ile Val Val Glu Phe Phe Val Val Thr Phe Lys Val Leu Trp 
1               5                   10                  15      


Ala Phe Val Leu Ala Ala Ala Arg Trp Leu Val Arg Pro Lys Glu Lys 
            20                  25                  30          


Ser Val Ala Gly Gln Val Cys Leu Ile Thr Gly Ala Gly Ser Gly Leu 
        35                  40                  45              


Gly Arg Leu Phe Ala Leu Glu Phe Ala Arg Arg Arg Ala Leu Leu Val 
    50                  55                  60                  


Leu Trp Asp Ile Asn Thr Gln Ser Asn Glu Glu Thr Ala Gly Met Val 
65                  70                  75                  80  


Arg His Ile Tyr Arg Asp Leu Glu Ala Ala Asp Ala Ala Ala Leu Gln 
                85                  90                  95      


Ala Gly Asn Gly Glu Glu Glu Ile Leu Pro His Cys Asn Leu Gln Val 
            100                 105                 110         


Phe Thr Tyr Thr Cys Asp Val Gly Lys Arg Glu Asn Val Tyr Leu Thr 
        115                 120                 125             


Ala Glu Arg Val Arg Lys Glu Val Gly Glu Val Ser Val Leu Val Asn 
    130                 135                 140                 


Asn Ala Gly Val Val Ser Gly His His Leu Leu Glu Cys Pro Asp Glu 
145                 150                 155                 160 


Leu Ile Glu Arg Thr Met Met Val Asn Cys His Ala His Phe Trp Thr 
                165                 170                 175     


Thr Lys Ala Phe Leu Pro Thr Met Leu Glu Ile Asn His Gly His Ile 
            180                 185                 190         


Val Thr Val Ala Ser Ser Leu Gly Leu Phe Ser Thr Ala Gly Val Glu 
        195                 200                 205             


Asp Tyr Cys Ala Ser Lys Phe Gly Val Val Gly Phe His Glu Ser Leu 
    210                 215                 220                 


Ser His Glu Leu Lys Ala Ala Glu Lys Asp Gly Ile Lys Thr Thr Leu 
225                 230                 235                 240 


Val Cys Pro Tyr Leu Val Asp Thr Gly Met Phe Arg Gly Cys Arg Ile 
                245                 250                 255     


Arg Lys Glu Ile Glu Pro Phe Leu Pro Pro Leu Lys Pro Asp Tyr Cys 
            260                 265                 270         


Val Lys Gln Ala Met Lys Ala Ile Leu Thr Asp Gln Pro Met Ile Cys 
        275                 280                 285             


Thr Pro Arg Leu Met Tyr Ile Val Thr Phe Met Lys Ser Ile Leu Pro 
    290                 295                 300                 


Phe Glu Ala Val Val Cys Met Tyr Arg Phe Leu Gly Ala Asp Lys Cys 
305                 310                 315                 320 


Met Tyr Pro Phe Ile Ala Gln Arg Lys Gln Ala Thr Asn Asn Asn Glu 
                325                 330                 335     


Ala Lys Asn Gly Ile 
            340     


<210>  6271
<211>  888
<212>  PRT
<213>  Homo sapiens

<400>  6271

Met Pro Val Arg Arg Gly His Val Ala Pro Gln Asn Thr Phe Leu Asp 
1               5                   10                  15      


Thr Ile Ile Arg Lys Phe Glu Gly Gln Ser Arg Lys Phe Ile Ile Ala 
            20                  25                  30          


Asn Ala Arg Val Glu Asn Cys Ala Val Ile Tyr Cys Asn Asp Gly Phe 
        35                  40                  45              


Cys Glu Leu Cys Gly Tyr Ser Arg Ala Glu Val Met Gln Arg Pro Cys 
    50                  55                  60                  


Thr Cys Asp Phe Leu His Gly Pro Arg Thr Gln Arg Arg Ala Ala Ala 
65                  70                  75                  80  


Gln Ile Ala Gln Ala Leu Leu Gly Ala Glu Glu Arg Lys Val Glu Ile 
                85                  90                  95      


Ala Phe Tyr Arg Lys Asp Gly Ser Cys Phe Leu Cys Leu Val Asp Val 
            100                 105                 110         


Val Pro Val Lys Asn Glu Asp Gly Ala Val Ile Met Phe Ile Leu Asn 
        115                 120                 125             


Phe Glu Val Val Met Glu Lys Asp Met Val Gly Ser Pro Ala His Asp 
    130                 135                 140                 


Thr Asn His Arg Gly Pro Pro Thr Ser Trp Leu Ala Pro Gly Arg Ala 
145                 150                 155                 160 


Lys Thr Phe Arg Leu Lys Leu Pro Ala Leu Leu Ala Leu Thr Ala Arg 
                165                 170                 175     


Glu Ser Ser Val Arg Ser Gly Gly Ala Gly Gly Ala Gly Ala Pro Gly 
            180                 185                 190         


Ala Val Val Val Asp Val Asp Leu Thr Pro Ala Ala Pro Ser Ser Glu 
        195                 200                 205             


Ser Leu Ala Leu Asp Glu Val Thr Ala Met Asp Asn His Val Ala Gly 
    210                 215                 220                 


Leu Gly Pro Ala Glu Glu Arg Arg Ala Leu Val Gly Pro Gly Ser Pro 
225                 230                 235                 240 


Pro Arg Ser Ala Pro Gly Gln Leu Pro Ser Pro Arg Ala His Ser Leu 
                245                 250                 255     


Asn Pro Asp Ala Ser Gly Ser Ser Cys Ser Leu Ala Arg Thr Arg Ser 
            260                 265                 270         


Arg Glu Ser Cys Ala Ser Val Arg Arg Ala Ser Ser Ala Asp Asp Ile 
        275                 280                 285             


Glu Ala Met Arg Ala Gly Val Leu Pro Pro Pro Pro Arg His Ala Ser 
    290                 295                 300                 


Thr Gly Ala Met His Pro Leu Arg Ser Gly Leu Leu Asn Ser Thr Ser 
305                 310                 315                 320 


Asp Ser Asp Leu Val Arg Tyr Arg Thr Ile Ser Lys Ile Pro Gln Ile 
                325                 330                 335     


Thr Leu Asn Phe Val Asp Leu Lys Gly Asp Pro Phe Leu Ala Ser Pro 
            340                 345                 350         


Thr Ser Asp Arg Glu Ile Ile Ala Pro Lys Ile Lys Glu Arg Thr His 
        355                 360                 365             


Asn Val Thr Glu Lys Val Thr Gln Val Leu Ser Leu Gly Ala Asp Val 
    370                 375                 380                 


Leu Pro Glu Tyr Lys Leu Gln Ala Pro Arg Ile His Arg Trp Thr Ile 
385                 390                 395                 400 


Leu His Tyr Ser Pro Phe Lys Ala Val Trp Asp Trp Leu Ile Leu Leu 
                405                 410                 415     


Leu Val Ile Tyr Thr Ala Val Phe Thr Pro Tyr Ser Ala Ala Phe Leu 
            420                 425                 430         


Leu Lys Glu Thr Glu Glu Gly Pro Pro Ala Thr Glu Cys Gly Tyr Ala 
        435                 440                 445             


Cys Gln Pro Leu Ala Val Val Asp Leu Ile Val Asp Ile Met Phe Ile 
    450                 455                 460                 


Val Asp Ile Leu Ile Asn Phe Arg Thr Thr Tyr Val Asn Ala Asn Glu 
465                 470                 475                 480 


Glu Val Val Ser His Pro Gly Arg Ile Ala Val His Tyr Phe Lys Gly 
                485                 490                 495     


Trp Phe Leu Ile Asp Met Val Ala Ala Ile Pro Phe Asp Leu Leu Ile 
            500                 505                 510         


Phe Gly Ser Gly Ser Glu Glu Leu Ile Gly Leu Leu Lys Thr Ala Arg 
        515                 520                 525             


Leu Leu Arg Leu Val Arg Val Ala Arg Lys Leu Asp Arg Tyr Ser Glu 
    530                 535                 540                 


Tyr Gly Ala Ala Val Leu Phe Leu Leu Met Cys Thr Phe Ala Leu Ile 
545                 550                 555                 560 


Ala His Trp Leu Ala Cys Ile Trp Tyr Ala Ile Gly Asn Met Glu Gln 
                565                 570                 575     


Pro His Met Asp Ser Arg Ile Gly Trp Leu His Asn Leu Gly Asp Gln 
            580                 585                 590         


Ile Gly Lys Pro Tyr Asn Ser Ser Gly Leu Gly Gly Pro Ser Ile Lys 
        595                 600                 605             


Asp Lys Tyr Val Thr Ala Leu Tyr Phe Thr Phe Ser Ser Leu Thr Ser 
    610                 615                 620                 


Val Gly Phe Gly Asn Val Ser Pro Asn Thr Asn Ser Glu Lys Ile Phe 
625                 630                 635                 640 


Ser Ile Cys Val Met Leu Ile Gly Ser Leu Met Tyr Ala Ser Ile Phe 
                645                 650                 655     


Gly Asn Val Ser Ala Ile Ile Gln Arg Leu Tyr Ser Gly Thr Ala Arg 
            660                 665                 670         


Tyr His Thr Gln Met Leu Arg Val Arg Glu Phe Ile Arg Phe His Gln 
        675                 680                 685             


Ile Pro Asn Pro Leu Arg Gln Arg Leu Glu Glu Tyr Phe Gln His Ala 
    690                 695                 700                 


Trp Ser Tyr Thr Asn Gly Ile Asp Met Asn Ala Val Leu Lys Gly Phe 
705                 710                 715                 720 


Pro Glu Cys Leu Gln Ala Asp Ile Cys Leu His Leu Asn Arg Ser Leu 
                725                 730                 735     


Leu Gln His Cys Lys Pro Phe Arg Gly Ala Thr Lys Gly Cys Leu Arg 
            740                 745                 750         


Ala Leu Ala Met Lys Phe Lys Thr Thr His Ala Pro Pro Gly Asp Thr 
        755                 760                 765             


Leu Val His Ala Gly Asp Leu Leu Thr Ala Leu Tyr Phe Ile Ser Arg 
    770                 775                 780                 


Gly Ser Ile Glu Ile Leu Arg Gly Asp Val Val Val Ala Ile Leu Gly 
785                 790                 795                 800 


Met Gly Trp Gly Ala Gly Thr Gly Leu Glu Met Pro Ser Ala Ala Ser 
                805                 810                 815     


Arg Gly Ala Ser Leu Leu Asn Met Gln Ser Leu Gly Leu Trp Thr Trp 
            820                 825                 830         


Asp Cys Leu Gln Gly His Trp Ala Pro Leu Ile His Leu Asn Ser Gly 
        835                 840                 845             


Pro Pro Ser Gly Ala Met Glu Arg Ser Pro Thr Trp Gly Glu Ala Ala 
    850                 855                 860                 


Glu Leu Trp Gly Ser His Ile Leu Leu Pro Phe Arg Ile Arg His Lys 
865                 870                 875                 880 


Gln Thr Leu Phe Ala Ser Leu Lys 
                885             


<210>  6272
<211>  819
<212>  PRT
<213>  Homo sapiens

<400>  6272

Met Ala Ala Pro Ala Gly Lys Ala Ser Arg Thr Gly Ala Leu Arg Pro 
1               5                   10                  15      


Arg Ala Gln Lys Gly Arg Val Arg Arg Ala Val Arg Ile Ser Ser Leu 
            20                  25                  30          


Val Ala Gln Glu Val Leu Ser Leu Gly Ala Asp Val Leu Pro Glu Tyr 
        35                  40                  45              


Lys Leu Gln Ala Pro Arg Ile His Arg Trp Thr Ile Leu His Tyr Ser 
    50                  55                  60                  


Pro Phe Lys Ala Val Trp Asp Trp Leu Ile Leu Leu Leu Val Ile Tyr 
65                  70                  75                  80  


Thr Ala Val Phe Thr Pro Tyr Ser Ala Ala Phe Leu Leu Lys Glu Thr 
                85                  90                  95      


Glu Glu Gly Pro Pro Ala Thr Glu Cys Gly Tyr Ala Cys Gln Pro Leu 
            100                 105                 110         


Ala Val Val Asp Leu Ile Val Asp Ile Met Phe Ile Val Asp Ile Leu 
        115                 120                 125             


Ile Asn Phe Arg Thr Thr Tyr Val Asn Ala Asn Glu Glu Val Val Ser 
    130                 135                 140                 


His Pro Gly Arg Ile Ala Val His Tyr Phe Lys Gly Trp Phe Leu Ile 
145                 150                 155                 160 


Asp Met Val Ala Ala Ile Pro Phe Asp Leu Leu Ile Phe Gly Ser Gly 
                165                 170                 175     


Ser Glu Glu Leu Ile Gly Leu Leu Lys Thr Ala Arg Leu Leu Arg Leu 
            180                 185                 190         


Val Arg Val Ala Arg Lys Leu Asp Arg Tyr Ser Glu Tyr Gly Ala Ala 
        195                 200                 205             


Val Leu Phe Leu Leu Met Cys Thr Phe Ala Leu Ile Ala His Trp Leu 
    210                 215                 220                 


Ala Cys Ile Trp Tyr Ala Ile Gly Asn Met Glu Gln Pro His Met Asp 
225                 230                 235                 240 


Ser Arg Ile Gly Trp Leu His Asn Leu Gly Asp Gln Ile Gly Lys Pro 
                245                 250                 255     


Tyr Asn Ser Ser Gly Leu Gly Gly Pro Ser Ile Lys Asp Lys Tyr Val 
            260                 265                 270         


Thr Ala Leu Tyr Phe Thr Phe Ser Ser Leu Thr Ser Val Gly Phe Gly 
        275                 280                 285             


Asn Val Ser Pro Asn Thr Asn Ser Glu Lys Ile Phe Ser Ile Cys Val 
    290                 295                 300                 


Met Leu Ile Gly Ser Leu Met Tyr Ala Ser Ile Phe Gly Asn Val Ser 
305                 310                 315                 320 


Ala Ile Ile Gln Arg Leu Tyr Ser Gly Thr Ala Arg Tyr His Thr Gln 
                325                 330                 335     


Met Leu Arg Val Arg Glu Phe Ile Arg Phe His Gln Ile Pro Asn Pro 
            340                 345                 350         


Leu Arg Gln Arg Leu Glu Glu Tyr Phe Gln His Ala Trp Ser Tyr Thr 
        355                 360                 365             


Asn Gly Ile Asp Met Asn Ala Val Leu Lys Gly Phe Pro Glu Cys Leu 
    370                 375                 380                 


Gln Ala Asp Ile Cys Leu His Leu Asn Arg Ser Leu Leu Gln His Cys 
385                 390                 395                 400 


Lys Pro Phe Arg Gly Ala Thr Lys Gly Cys Leu Arg Ala Leu Ala Met 
                405                 410                 415     


Lys Phe Lys Thr Thr His Ala Pro Pro Gly Asp Thr Leu Val His Ala 
            420                 425                 430         


Gly Asp Leu Leu Thr Ala Leu Tyr Phe Ile Ser Arg Gly Ser Ile Glu 
        435                 440                 445             


Ile Leu Arg Gly Asp Val Val Val Ala Ile Leu Gly Lys Asn Asp Ile 
    450                 455                 460                 


Phe Gly Glu Pro Leu Asn Leu Tyr Ala Arg Pro Gly Lys Ser Asn Gly 
465                 470                 475                 480 


Asp Val Arg Ala Leu Thr Tyr Cys Asp Leu His Lys Ile His Arg Asp 
                485                 490                 495     


Asp Leu Leu Glu Val Leu Asp Met Tyr Pro Glu Phe Ser Asp His Phe 
            500                 505                 510         


Trp Ser Ser Leu Glu Ile Thr Phe Asn Leu Arg Asp Thr Asn Met Ile 
        515                 520                 525             


Pro Gly Ser Pro Gly Ser Thr Glu Leu Glu Gly Gly Phe Ser Arg Gln 
    530                 535                 540                 


Arg Lys Arg Lys Leu Ser Phe Arg Arg Arg Thr Asp Lys Asp Thr Glu 
545                 550                 555                 560 


Gln Pro Gly Glu Val Ser Ala Leu Gly Pro Gly Arg Ala Gly Ala Gly 
                565                 570                 575     


Pro Ser Ser Arg Gly Arg Pro Gly Gly Pro Trp Gly Glu Ser Pro Ser 
            580                 585                 590         


Ser Gly Pro Ser Ser Pro Glu Ser Ser Glu Asp Glu Gly Pro Gly Arg 
        595                 600                 605             


Ser Ser Ser Pro Leu Arg Leu Val Pro Phe Ser Ser Pro Arg Pro Pro 
    610                 615                 620                 


Gly Glu Pro Pro Gly Gly Glu Pro Leu Met Glu Asp Cys Glu Lys Ser 
625                 630                 635                 640 


Ser Asp Thr Cys Asn Pro Leu Ser Gly Ala Phe Ser Gly Val Ser Asn 
                645                 650                 655     


Ile Phe Ser Phe Trp Gly Asp Ser Arg Gly Arg Gln Tyr Gln Glu Leu 
            660                 665                 670         


Pro Arg Cys Pro Ala Pro Thr Pro Ser Leu Leu Asn Ile Pro Leu Ser 
        675                 680                 685             


Ser Pro Gly Arg Arg Pro Arg Gly Asp Val Glu Ser Arg Leu Asp Ala 
    690                 695                 700                 


Leu Gln Arg Gln Leu Asn Arg Leu Glu Thr Arg Leu Ser Ala Asp Met 
705                 710                 715                 720 


Ala Thr Val Leu Gln Leu Leu Gln Arg Gln Met Thr Leu Val Pro Pro 
                725                 730                 735     


Ala Tyr Ser Ala Val Thr Thr Pro Gly Pro Gly Pro Thr Ser Thr Ser 
            740                 745                 750         


Pro Leu Leu Pro Val Ser Pro Leu Pro Thr Leu Thr Leu Asp Ser Leu 
        755                 760                 765             


Ser Gln Val Ser Gln Phe Met Ala Cys Glu Glu Leu Pro Pro Gly Ala 
    770                 775                 780                 


Pro Glu Leu Pro Gln Glu Gly Pro Thr Arg Arg Leu Ser Leu Pro Gly 
785                 790                 795                 800 


Gln Leu Gly Ala Leu Thr Ser Gln Pro Leu His Arg His Gly Ser Asp 
                805                 810                 815     


Pro Gly Ser 
            


<210>  6273
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  6273

Met Ala Ala Tyr Gln Gln Glu Glu Gln Met Gln Leu Pro Arg Ala Asp 
1               5                   10                  15      


Ala Ile Arg Ser Arg Leu Ile Asp Thr Phe Ser Leu Ile Glu His Leu 
            20                  25                  30          


Gln Gly Leu Ser Gln Ala Val Pro Arg His Thr Ile Arg Glu Leu Leu 
        35                  40                  45              


Asp Pro Ser Arg Gln Lys Lys Leu Val Leu Gly Asp Gln His Gln Leu 
    50                  55                  60                  


Val Arg Phe Ser Ile Lys Pro Gln Arg Ile Glu Gln Ile Ser His Ala 
65                  70                  75                  80  


Gln Arg Leu Leu Ser Arg Leu His Val Arg Cys Ser Gln Arg Pro Pro 
                85                  90                  95      


Leu Ser Leu Trp Ala Gly Trp Val Leu Glu Cys Pro Leu Phe Lys Asn 
            100                 105                 110         


Phe Ile Ile Phe Leu Val Phe Leu Asn Thr Ile Ile Leu Met Val Glu 
        115                 120                 125             


Ile Glu Leu Leu Glu Ser Thr Asn Thr Lys Leu Trp Pro Leu Lys Leu 
    130                 135                 140                 


Thr Leu Glu Val Ala Ala Trp Phe Ile Leu Leu Ile Phe Ile Leu Glu 
145                 150                 155                 160 


Ile Leu Leu Lys Trp Leu Ser Asn Phe Ser Val Phe Trp Lys Ser Ala 
                165                 170                 175     


Trp Asn Val Phe Asp Phe Val Val Thr Met Leu Ser Leu Leu Pro Glu 
            180                 185                 190         


Val Val Val Leu Val Gly Val Thr Gly Gln Ser Val Trp Leu Gln Leu 
        195                 200                 205             


Leu Arg Ile Cys Arg Val Leu Arg Ser Leu Lys Leu Leu Ala Gln Phe 
    210                 215                 220                 


Arg Gln Ile Gln Ile Ile Ile Leu Val Leu Val Arg Ala Leu Lys Ser 
225                 230                 235                 240 


Met Thr Phe Leu Leu Met Leu Leu Leu Ile Phe Phe Tyr Ile Phe Ala 
                245                 250                 255     


Val Thr Gly Val Tyr Val Phe Ser Glu Tyr Thr Arg Ser Pro Arg Gln 
            260                 265                 270         


Asp Leu Glu Tyr His Val Phe Phe Ser Asp Leu Pro Asn Ser Leu Val 
        275                 280                 285             


Thr Val Phe Ile Leu Phe Thr Leu Asp His Trp Tyr Ala Leu Leu Gln 
    290                 295                 300                 


Asp Val Trp Lys Val Pro Glu Val Ser Arg Ile Phe Ser Ser Ile Tyr 
305                 310                 315                 320 


Phe Ile Leu Trp Leu Leu Leu Gly Ser Ile Ile Phe Arg Ser Ile Ile 
                325                 330                 335     


Val Ala Met Met Val Thr Asn Phe Gln Asn Ile Arg Lys Glu Leu Asn 
            340                 345                 350         


Glu Glu Met Ala Arg Arg Glu Val Gln Leu Lys Ala Asp Met Phe Lys 
        355                 360                 365             


Arg Gln Ile Ile Gln Arg Arg Lys Asn Met Ser His Glu Ala Leu Thr 
    370                 375                 380                 


Ser Ser His Ser Lys Ile Glu Asp Ser Ser Arg Gly Ala Ser Gln Gln 
385                 390                 395                 400 


Arg Glu Ser Leu Asp Leu Ser Glu Val Ser Glu Val Glu Ser Asn Tyr 
                405                 410                 415     


Gly Ala Thr Glu Glu Asp Leu Ile Thr Ser Ala Ser Lys Thr Glu Glu 
            420                 425                 430         


Thr Leu Ser Lys Lys Arg Glu Tyr Gln Ser Ser Ser Cys Val Ser Ser 
        435                 440                 445             


Thr Ser Ser Ser Tyr Ser Ser Ser Ser Glu Ser Arg Phe Ser Glu Ser 
    450                 455                 460                 


Ile Gly Arg Leu Asp Trp Glu Thr Leu Val His Glu Asn Leu Pro Gly 
465                 470                 475                 480 


Leu Met Glu Met Asp Gln Asp Asp Arg Val Trp Pro Arg Asp Ser Leu 
                485                 490                 495     


Phe Arg Tyr Phe Glu Leu Leu Glu Lys Leu Gln Tyr Asn Leu Glu Glu 
            500                 505                 510         


Arg Lys Lys Leu Gln Glu Phe Ala Val Gln Ala Leu Met Asn Leu Glu 
        515                 520                 525             


Asp Lys 
    530 


<210>  6274
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  6274

Met Ala Ala Tyr Gln Gln Glu Glu Gln Met Gln Leu Pro Arg Ala Asp 
1               5                   10                  15      


Ala Ile Arg Ser Arg Leu Ile Asp Thr Phe Ser Leu Ile Glu His Leu 
            20                  25                  30          


Gln Gly Leu Ser Gln Ala Val Pro Arg His Thr Ile Arg Glu Leu Leu 
        35                  40                  45              


Asp Pro Ser Arg Gln Lys Lys Leu Val Leu Gly Asp Gln His Gln Leu 
    50                  55                  60                  


Val Arg Phe Ser Ile Lys Pro Gln Arg Ile Glu Gln Ile Ser His Ala 
65                  70                  75                  80  


Gln Arg Leu Leu Ser Arg Leu His Val Arg Cys Ser Gln Arg Pro Pro 
                85                  90                  95      


Leu Ser Leu Trp Ala Gly Trp Val Leu Glu Cys Pro Leu Phe Lys Asn 
            100                 105                 110         


Phe Ile Ile Phe Leu Val Phe Leu Asn Thr Ile Ile Leu Met Val Glu 
        115                 120                 125             


Ile Glu Leu Leu Glu Ser Thr Asn Thr Lys Leu Trp Pro Leu Lys Leu 
    130                 135                 140                 


Thr Leu Glu Val Ala Ala Trp Phe Ile Leu Leu Ile Phe Ile Leu Glu 
145                 150                 155                 160 


Ile Leu Leu Lys Trp Leu Ser Asn Phe Ser Val Phe Trp Lys Ser Ala 
                165                 170                 175     


Trp Asn Val Phe Asp Phe Val Val Thr Met Leu Ser Leu Leu Pro Glu 
            180                 185                 190         


Val Val Val Leu Val Gly Val Thr Gly Gln Ser Val Trp Leu Gln Leu 
        195                 200                 205             


Leu Arg Ile Cys Arg Val Leu Arg Ser Leu Lys Leu Leu Ala Gln Phe 
    210                 215                 220                 


Arg Gln Ile Gln Ile Ile Ile Leu Val Leu Val Arg Ala Leu Lys Ser 
225                 230                 235                 240 


Met Thr Phe Leu Leu Met Leu Leu Leu Ile Phe Phe Tyr Ile Phe Ala 
                245                 250                 255     


Val Thr Gly Val Tyr Val Phe Ser Glu Tyr Thr Arg Ser Pro Arg Gln 
            260                 265                 270         


Asp Leu Glu Tyr His Val Phe Phe Ser Asp Leu Pro Asn Ser Leu Val 
        275                 280                 285             


Thr Val Phe Ile Leu Phe Thr Leu Asp His Trp Tyr Ala Leu Leu Gln 
    290                 295                 300                 


Asp Val Trp Lys Val Pro Glu Val Ser Arg Ile Phe Ser Ser Ile Tyr 
305                 310                 315                 320 


Phe Ile Leu Trp Leu Leu Leu Gly Ser Ile Ile Phe Arg Ser Ile Ile 
                325                 330                 335     


Val Ala Met Met Val Thr Asn Phe Gln Asn Ile Arg Lys Glu Leu Asn 
            340                 345                 350         


Glu Glu Met Ala Arg Arg Glu Val Gln Leu Lys Ala Asp Met Phe Lys 
        355                 360                 365             


Arg Gln Ile Ile Gln Arg Arg Lys Asn Met Ser His Glu Ala Leu Thr 
    370                 375                 380                 


Ser Ser His Ser Lys Ile Glu Asp Ser Ser Arg Gly Ala Ser Gln Gln 
385                 390                 395                 400 


Arg Glu Ser Leu Asp Leu Ser Glu Val Ser Glu Val Glu Ser Asn Tyr 
                405                 410                 415     


Gly Ala Thr Glu Glu Asp Leu Ile Thr Ser Ala Ser Lys Thr Glu Glu 
            420                 425                 430         


Thr Leu Ser Lys Lys Arg Glu Tyr Gln Ser Ser Ser Cys Val Ser Ser 
        435                 440                 445             


Thr Ser Ser Ser Tyr Ser Ser Ser Ser Glu Ser Arg Phe Ser Glu Ser 
    450                 455                 460                 


Ile Gly Arg Leu Asp Trp Glu Thr Leu Val His Glu Asn Leu Pro Gly 
465                 470                 475                 480 


Leu Met Glu Met Asp Gln Asp Asp Arg Val Trp Pro Arg Asp Ser Leu 
                485                 490                 495     


Phe Arg Tyr Phe Glu Leu Leu Glu Lys Leu Gln Tyr Asn Leu Glu Glu 
            500                 505                 510         


Arg Lys Lys Leu Gln Glu Phe Ala Val Gln Ala Leu Met Asn Leu Glu 
        515                 520                 525             


Asp Lys 
    530 


<210>  6275
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  6275

Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Thr Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro 
    130                 135                 140                 


Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Thr Gln Lys Gly Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu 
                165                 170                 175     


Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Ile His 
            180                 185                 190         


Leu Cys Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Leu 
        195                 200                 205             


Arg Leu His Pro Leu Glu Lys Cys Ser Arg Met Asp Tyr 
    210                 215                 220     


<210>  6276
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  6276

Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Thr Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro 
    130                 135                 140                 


Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Thr Gln Lys Gly Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu 
                165                 170                 175     


Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Ile His 
            180                 185                 190         


Leu Cys Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Leu 
        195                 200                 205             


Arg Leu His Pro Leu Glu Lys Cys Ser Arg Met Asp Tyr 
    210                 215                 220     


<210>  6277
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  6277

Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Thr Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro 
    130                 135                 140                 


Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Thr Gln Lys Gly Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys 
                165                 170                 175     


Gln Pro Gln Gly Glu Gly Ile Ser Gly Thr Phe Val Pro Gln Cys Leu 
            180                 185                 190         


His Gly Tyr Tyr Ser Asn Thr Thr Thr Ser Gln Lys Leu Leu Asn Pro 
        195                 200                 205             


Trp Ile Leu Lys Thr 
    210             


<210>  6278
<211>  854
<212>  PRT
<213>  Homo sapiens

<400>  6278

Met Val Gln Lys Ser Arg Asn Gly Gly Val Tyr Pro Gly Pro Ser Gly 
1               5                   10                  15      


Glu Lys Lys Leu Lys Val Gly Phe Val Gly Leu Asp Pro Gly Ala Pro 
            20                  25                  30          


Asp Ser Thr Arg Asp Gly Ala Leu Leu Ile Ala Gly Ser Glu Ala Pro 
        35                  40                  45              


Lys Arg Gly Ser Ile Leu Ser Lys Pro Arg Ala Gly Gly Ala Gly Ala 
    50                  55                  60                  


Gly Lys Pro Pro Lys Arg Asn Ala Phe Tyr Arg Lys Leu Gln Asn Phe 
65                  70                  75                  80  


Leu Tyr Asn Val Leu Glu Arg Pro Arg Gly Trp Ala Phe Ile Tyr His 
                85                  90                  95      


Ala Tyr Val Phe Leu Leu Val Phe Ser Cys Leu Val Leu Ser Val Phe 
            100                 105                 110         


Ser Thr Ile Lys Glu Tyr Glu Lys Ser Ser Glu Gly Ala Leu Tyr Ile 
        115                 120                 125             


Leu Glu Ile Val Thr Ile Val Val Phe Gly Val Glu Tyr Phe Val Arg 
    130                 135                 140                 


Ile Trp Ala Ala Gly Cys Cys Cys Arg Tyr Arg Gly Trp Arg Gly Arg 
145                 150                 155                 160 


Leu Lys Phe Ala Arg Lys Pro Phe Cys Val Ile Asp Ile Met Val Leu 
                165                 170                 175     


Ile Ala Ser Ile Ala Val Leu Ala Ala Gly Ser Gln Gly Asn Val Phe 
            180                 185                 190         


Ala Thr Ser Ala Leu Arg Ser Leu Arg Phe Leu Gln Ile Leu Arg Met 
        195                 200                 205             


Ile Arg Met Asp Arg Arg Gly Gly Thr Trp Lys Leu Leu Gly Ser Val 
    210                 215                 220                 


Val Tyr Ala His Ser Lys Glu Leu Val Thr Ala Trp Tyr Ile Gly Phe 
225                 230                 235                 240 


Leu Cys Leu Ile Leu Ala Ser Phe Leu Val Tyr Leu Ala Glu Lys Gly 
                245                 250                 255     


Glu Asn Asp His Phe Asp Thr Tyr Ala Asp Ala Leu Trp Trp Gly Leu 
            260                 265                 270         


Ile Thr Leu Thr Thr Ile Gly Tyr Gly Asp Lys Tyr Pro Gln Thr Trp 
        275                 280                 285             


Asn Gly Arg Leu Leu Ala Ala Thr Phe Thr Leu Ile Gly Val Ser Phe 
    290                 295                 300                 


Phe Ala Leu Pro Ala Gly Ile Leu Gly Ser Gly Phe Ala Leu Lys Val 
305                 310                 315                 320 


Gln Glu Gln His Arg Gln Lys His Phe Glu Lys Arg Arg Asn Pro Ala 
                325                 330                 335     


Ala Gly Leu Ile Gln Ser Ala Trp Arg Phe Tyr Ala Thr Asn Leu Ser 
            340                 345                 350         


Arg Thr Asp Leu His Ser Thr Trp Gln Tyr Tyr Glu Arg Thr Val Thr 
        355                 360                 365             


Val Pro Met Tyr Ser Ser Gln Thr Gln Thr Tyr Gly Ala Ser Arg Leu 
    370                 375                 380                 


Ile Pro Pro Leu Asn Gln Leu Glu Leu Leu Arg Asn Leu Lys Ser Lys 
385                 390                 395                 400 


Ser Gly Leu Ala Phe Arg Lys Asp Pro Pro Pro Glu Pro Ser Pro Ser 
                405                 410                 415     


Gln Lys Val Ser Leu Lys Asp Arg Val Phe Ser Ser Pro Arg Gly Val 
            420                 425                 430         


Ala Ala Lys Gly Lys Gly Ser Pro Gln Ala Gln Thr Val Arg Arg Ser 
        435                 440                 445             


Pro Ser Ala Asp Gln Ser Leu Glu Asp Ser Pro Ser Lys Val Pro Lys 
    450                 455                 460                 


Ser Trp Ser Phe Gly Asp Arg Ser Arg Ala Arg Gln Ala Phe Arg Ile 
465                 470                 475                 480 


Lys Gly Ala Ala Ser Arg Gln Asn Ser Glu Glu Ala Ser Leu Pro Gly 
                485                 490                 495     


Glu Asp Ile Val Asp Asp Lys Ser Cys Pro Cys Glu Phe Val Thr Glu 
            500                 505                 510         


Asp Leu Thr Pro Gly Leu Lys Val Ser Ile Arg Ala Val Cys Val Met 
        515                 520                 525             


Arg Phe Leu Val Ser Lys Arg Lys Phe Lys Glu Ser Leu Arg Pro Tyr 
    530                 535                 540                 


Asp Val Met Asp Val Ile Glu Gln Tyr Ser Ala Gly His Leu Asp Met 
545                 550                 555                 560 


Leu Ser Arg Ile Lys Ser Leu Gln Ser Arg Val Asp Gln Ile Val Gly 
                565                 570                 575     


Arg Gly Pro Ala Ile Thr Asp Lys Asp Arg Thr Lys Gly Pro Ala Glu 
            580                 585                 590         


Ala Glu Leu Pro Glu Asp Pro Ser Met Met Gly Arg Leu Gly Lys Val 
        595                 600                 605             


Glu Lys Gln Val Leu Ser Met Glu Lys Lys Leu Asp Phe Leu Val Asn 
    610                 615                 620                 


Ile Tyr Met Gln Arg Met Gly Ile Pro Pro Thr Glu Thr Glu Ala Tyr 
625                 630                 635                 640 


Phe Gly Ala Lys Glu Pro Glu Pro Ala Pro Pro Tyr His Ser Pro Glu 
                645                 650                 655     


Asp Ser Arg Glu His Val Asp Arg His Gly Cys Ile Val Lys Ile Val 
            660                 665                 670         


Arg Ser Ser Ser Ser Thr Gly Gln Lys Asn Phe Ser Ala Pro Pro Ala 
        675                 680                 685             


Ala Pro Pro Val Gln Cys Pro Pro Ser Thr Ser Trp Gln Pro Gln Ser 
    690                 695                 700                 


His Pro Arg Gln Gly His Gly Thr Ser Pro Val Gly Asp His Gly Ser 
705                 710                 715                 720 


Leu Val Arg Ile Pro Pro Pro Pro Ala His Glu Arg Ser Leu Ser Ala 
                725                 730                 735     


Tyr Gly Gly Gly Asn Arg Ala Ser Met Glu Phe Leu Arg Gln Glu Asp 
            740                 745                 750         


Thr Pro Gly Cys Arg Pro Pro Glu Gly Asn Leu Arg Asp Ser Asp Thr 
        755                 760                 765             


Ser Ile Ser Ile Pro Ser Val Asp His Glu Glu Leu Glu Arg Ser Phe 
    770                 775                 780                 


Ser Gly Phe Ser Ile Ser Gln Ser Lys Glu Asn Leu Asp Ala Leu Asn 
785                 790                 795                 800 


Ser Cys Tyr Ala Ala Val Ala Pro Cys Ala Lys Val Arg Pro Tyr Ile 
                805                 810                 815     


Ala Glu Gly Glu Ser Asp Thr Asp Ser Asp Leu Cys Thr Pro Cys Gly 
            820                 825                 830         


Pro Pro Pro Arg Ser Ala Thr Gly Glu Gly Pro Phe Gly Asp Val Gly 
        835                 840                 845             


Trp Ala Gly Pro Arg Lys 
    850                 


<210>  6279
<211>  872
<212>  PRT
<213>  Homo sapiens

<400>  6279

Met Val Gln Lys Ser Arg Asn Gly Gly Val Tyr Pro Gly Pro Ser Gly 
1               5                   10                  15      


Glu Lys Lys Leu Lys Val Gly Phe Val Gly Leu Asp Pro Gly Ala Pro 
            20                  25                  30          


Asp Ser Thr Arg Asp Gly Ala Leu Leu Ile Ala Gly Ser Glu Ala Pro 
        35                  40                  45              


Lys Arg Gly Ser Ile Leu Ser Lys Pro Arg Ala Gly Gly Ala Gly Ala 
    50                  55                  60                  


Gly Lys Pro Pro Lys Arg Asn Ala Phe Tyr Arg Lys Leu Gln Asn Phe 
65                  70                  75                  80  


Leu Tyr Asn Val Leu Glu Arg Pro Arg Gly Trp Ala Phe Ile Tyr His 
                85                  90                  95      


Ala Tyr Val Phe Leu Leu Val Phe Ser Cys Leu Val Leu Ser Val Phe 
            100                 105                 110         


Ser Thr Ile Lys Glu Tyr Glu Lys Ser Ser Glu Gly Ala Leu Tyr Ile 
        115                 120                 125             


Leu Glu Ile Val Thr Ile Val Val Phe Gly Val Glu Tyr Phe Val Arg 
    130                 135                 140                 


Ile Trp Ala Ala Gly Cys Cys Cys Arg Tyr Arg Gly Trp Arg Gly Arg 
145                 150                 155                 160 


Leu Lys Phe Ala Arg Lys Pro Phe Cys Val Ile Asp Ile Met Val Leu 
                165                 170                 175     


Ile Ala Ser Ile Ala Val Leu Ala Ala Gly Ser Gln Gly Asn Val Phe 
            180                 185                 190         


Ala Thr Ser Ala Leu Arg Ser Leu Arg Phe Leu Gln Ile Leu Arg Met 
        195                 200                 205             


Ile Arg Met Asp Arg Arg Gly Gly Thr Trp Lys Leu Leu Gly Ser Val 
    210                 215                 220                 


Val Tyr Ala His Ser Lys Glu Leu Val Thr Ala Trp Tyr Ile Gly Phe 
225                 230                 235                 240 


Leu Cys Leu Ile Leu Ala Ser Phe Leu Val Tyr Leu Ala Glu Lys Gly 
                245                 250                 255     


Glu Asn Asp His Phe Asp Thr Tyr Ala Asp Ala Leu Trp Trp Gly Leu 
            260                 265                 270         


Ile Thr Leu Thr Thr Ile Gly Tyr Gly Asp Lys Tyr Pro Gln Thr Trp 
        275                 280                 285             


Asn Gly Arg Leu Leu Ala Ala Thr Phe Thr Leu Ile Gly Val Ser Phe 
    290                 295                 300                 


Phe Ala Leu Pro Ala Gly Ile Leu Gly Ser Gly Phe Ala Leu Lys Val 
305                 310                 315                 320 


Gln Glu Gln His Arg Gln Lys His Phe Glu Lys Arg Arg Asn Pro Ala 
                325                 330                 335     


Ala Gly Leu Ile Gln Ser Ala Trp Arg Phe Tyr Ala Thr Asn Leu Ser 
            340                 345                 350         


Arg Thr Asp Leu His Ser Thr Trp Gln Tyr Tyr Glu Arg Thr Val Thr 
        355                 360                 365             


Val Pro Met Tyr Ser Ser Gln Thr Gln Thr Tyr Gly Ala Ser Arg Leu 
    370                 375                 380                 


Ile Pro Pro Leu Asn Gln Leu Glu Leu Leu Arg Asn Leu Lys Ser Lys 
385                 390                 395                 400 


Ser Gly Leu Ala Phe Arg Lys Asp Pro Pro Pro Glu Pro Ser Pro Ser 
                405                 410                 415     


Lys Gly Ser Pro Cys Arg Gly Pro Leu Cys Gly Cys Cys Pro Gly Arg 
            420                 425                 430         


Ser Ser Gln Lys Val Ser Leu Lys Asp Arg Val Phe Ser Ser Pro Arg 
        435                 440                 445             


Gly Val Ala Ala Lys Gly Lys Gly Ser Pro Gln Ala Gln Thr Val Arg 
    450                 455                 460                 


Arg Ser Pro Ser Ala Asp Gln Ser Leu Glu Asp Ser Pro Ser Lys Val 
465                 470                 475                 480 


Pro Lys Ser Trp Ser Phe Gly Asp Arg Ser Arg Ala Arg Gln Ala Phe 
                485                 490                 495     


Arg Ile Lys Gly Ala Ala Ser Arg Gln Asn Ser Glu Glu Ala Ser Leu 
            500                 505                 510         


Pro Gly Glu Asp Ile Val Asp Asp Lys Ser Cys Pro Cys Glu Phe Val 
        515                 520                 525             


Thr Glu Asp Leu Thr Pro Gly Leu Lys Val Ser Ile Arg Ala Val Cys 
    530                 535                 540                 


Val Met Arg Phe Leu Val Ser Lys Arg Lys Phe Lys Glu Ser Leu Arg 
545                 550                 555                 560 


Pro Tyr Asp Val Met Asp Val Ile Glu Gln Tyr Ser Ala Gly His Leu 
                565                 570                 575     


Asp Met Leu Ser Arg Ile Lys Ser Leu Gln Ser Arg Val Asp Gln Ile 
            580                 585                 590         


Val Gly Arg Gly Pro Ala Ile Thr Asp Lys Asp Arg Thr Lys Gly Pro 
        595                 600                 605             


Ala Glu Ala Glu Leu Pro Glu Asp Pro Ser Met Met Gly Arg Leu Gly 
    610                 615                 620                 


Lys Val Glu Lys Gln Val Leu Ser Met Glu Lys Lys Leu Asp Phe Leu 
625                 630                 635                 640 


Val Asn Ile Tyr Met Gln Arg Met Gly Ile Pro Pro Thr Glu Thr Glu 
                645                 650                 655     


Ala Tyr Phe Gly Ala Lys Glu Pro Glu Pro Ala Pro Pro Tyr His Ser 
            660                 665                 670         


Pro Glu Asp Ser Arg Glu His Val Asp Arg His Gly Cys Ile Val Lys 
        675                 680                 685             


Ile Val Arg Ser Ser Ser Ser Thr Gly Gln Lys Asn Phe Ser Ala Pro 
    690                 695                 700                 


Pro Ala Ala Pro Pro Val Gln Cys Pro Pro Ser Thr Ser Trp Gln Pro 
705                 710                 715                 720 


Gln Ser His Pro Arg Gln Gly His Gly Thr Ser Pro Val Gly Asp His 
                725                 730                 735     


Gly Ser Leu Val Arg Ile Pro Pro Pro Pro Ala His Glu Arg Ser Leu 
            740                 745                 750         


Ser Ala Tyr Gly Gly Gly Asn Arg Ala Ser Met Glu Phe Leu Arg Gln 
        755                 760                 765             


Glu Asp Thr Pro Gly Cys Arg Pro Pro Glu Gly Asn Leu Arg Asp Ser 
    770                 775                 780                 


Asp Thr Ser Ile Ser Ile Pro Ser Val Asp His Glu Glu Leu Glu Arg 
785                 790                 795                 800 


Ser Phe Ser Gly Phe Ser Ile Ser Gln Ser Lys Glu Asn Leu Asp Ala 
                805                 810                 815     


Leu Asn Ser Cys Tyr Ala Ala Val Ala Pro Cys Ala Lys Val Arg Pro 
            820                 825                 830         


Tyr Ile Ala Glu Gly Glu Ser Asp Thr Asp Ser Asp Leu Cys Thr Pro 
        835                 840                 845             


Cys Gly Pro Pro Pro Arg Ser Ala Thr Gly Glu Gly Pro Phe Gly Asp 
    850                 855                 860                 


Val Gly Trp Ala Gly Pro Arg Lys 
865                 870         


<210>  6280
<211>  841
<212>  PRT
<213>  Homo sapiens

<400>  6280

Met Val Gln Lys Ser Arg Asn Gly Gly Val Tyr Pro Gly Pro Ser Gly 
1               5                   10                  15      


Glu Lys Lys Leu Lys Val Gly Phe Val Gly Leu Asp Pro Gly Ala Pro 
            20                  25                  30          


Asp Ser Thr Arg Asp Gly Ala Leu Leu Ile Ala Gly Ser Glu Ala Pro 
        35                  40                  45              


Lys Arg Gly Ser Ile Leu Ser Lys Pro Arg Ala Gly Gly Ala Gly Ala 
    50                  55                  60                  


Gly Lys Pro Pro Lys Arg Asn Ala Phe Tyr Arg Lys Leu Gln Asn Phe 
65                  70                  75                  80  


Leu Tyr Asn Val Leu Glu Arg Pro Arg Gly Trp Ala Phe Ile Tyr His 
                85                  90                  95      


Ala Tyr Val Phe Leu Leu Val Phe Ser Cys Leu Val Leu Ser Val Phe 
            100                 105                 110         


Ser Thr Ile Lys Glu Tyr Glu Lys Ser Ser Glu Gly Ala Leu Tyr Ile 
        115                 120                 125             


Leu Glu Ile Val Thr Ile Val Val Phe Gly Val Glu Tyr Phe Val Arg 
    130                 135                 140                 


Ile Trp Ala Ala Gly Cys Cys Cys Arg Tyr Arg Gly Trp Arg Gly Arg 
145                 150                 155                 160 


Leu Lys Phe Ala Arg Lys Pro Phe Cys Val Ile Asp Ile Met Val Leu 
                165                 170                 175     


Ile Ala Ser Ile Ala Val Leu Ala Ala Gly Ser Gln Gly Asn Val Phe 
            180                 185                 190         


Ala Thr Ser Ala Leu Arg Ser Leu Arg Phe Leu Gln Ile Leu Arg Met 
        195                 200                 205             


Ile Arg Met Asp Arg Arg Gly Gly Thr Trp Lys Leu Leu Gly Ser Val 
    210                 215                 220                 


Val Tyr Ala His Ser Lys Glu Leu Val Thr Ala Trp Tyr Ile Gly Phe 
225                 230                 235                 240 


Leu Cys Leu Ile Leu Ala Ser Phe Leu Val Tyr Leu Ala Glu Lys Gly 
                245                 250                 255     


Glu Asn Asp His Phe Asp Thr Tyr Ala Asp Ala Leu Trp Trp Gly Leu 
            260                 265                 270         


Ile Thr Leu Thr Thr Ile Gly Tyr Gly Asp Lys Tyr Pro Gln Thr Trp 
        275                 280                 285             


Asn Gly Arg Leu Leu Ala Ala Thr Phe Thr Leu Ile Gly Val Ser Phe 
    290                 295                 300                 


Phe Ala Leu Pro Ala Gly Ile Leu Gly Ser Gly Phe Ala Leu Lys Val 
305                 310                 315                 320 


Gln Glu Gln His Arg Gln Lys His Phe Glu Lys Arg Arg Asn Pro Ala 
                325                 330                 335     


Ala Gly Leu Ile Gln Ser Ala Trp Arg Phe Tyr Ala Thr Asn Leu Ser 
            340                 345                 350         


Arg Thr Asp Leu His Ser Thr Trp Gln Tyr Tyr Glu Arg Thr Val Thr 
        355                 360                 365             


Val Pro Met Tyr Ser Ser Gln Thr Gln Thr Tyr Gly Ala Ser Arg Leu 
    370                 375                 380                 


Ile Pro Pro Leu Asn Gln Leu Glu Leu Leu Arg Asn Leu Lys Ser Lys 
385                 390                 395                 400 


Ser Gly Leu Ala Phe Arg Lys Asp Pro Pro Pro Glu Pro Ser Pro Ser 
                405                 410                 415     


Pro Arg Gly Val Ala Ala Lys Gly Lys Gly Ser Pro Gln Ala Gln Thr 
            420                 425                 430         


Val Arg Arg Ser Pro Ser Ala Asp Gln Ser Leu Glu Asp Ser Pro Ser 
        435                 440                 445             


Lys Val Pro Lys Ser Trp Ser Phe Gly Asp Arg Ser Arg Ala Arg Gln 
    450                 455                 460                 


Ala Phe Arg Ile Lys Gly Ala Ala Ser Arg Gln Asn Ser Glu Ala Ser 
465                 470                 475                 480 


Leu Pro Gly Glu Asp Ile Val Asp Asp Lys Ser Cys Pro Cys Glu Phe 
                485                 490                 495     


Val Thr Glu Asp Leu Thr Pro Gly Leu Lys Val Ser Ile Arg Ala Val 
            500                 505                 510         


Cys Val Met Arg Phe Leu Val Ser Lys Arg Lys Phe Lys Glu Ser Leu 
        515                 520                 525             


Arg Pro Tyr Asp Val Met Asp Val Ile Glu Gln Tyr Ser Ala Gly His 
    530                 535                 540                 


Leu Asp Met Leu Ser Arg Ile Lys Ser Leu Gln Ser Arg Val Asp Gln 
545                 550                 555                 560 


Ile Val Gly Arg Gly Pro Ala Ile Thr Asp Lys Asp Arg Thr Lys Gly 
                565                 570                 575     


Pro Ala Glu Ala Glu Leu Pro Glu Asp Pro Ser Met Met Gly Arg Leu 
            580                 585                 590         


Gly Lys Val Glu Lys Gln Val Leu Ser Met Glu Lys Lys Leu Asp Phe 
        595                 600                 605             


Leu Val Asn Ile Tyr Met Gln Arg Met Gly Ile Pro Pro Thr Glu Thr 
    610                 615                 620                 


Glu Ala Tyr Phe Gly Ala Lys Glu Pro Glu Pro Ala Pro Pro Tyr His 
625                 630                 635                 640 


Ser Pro Glu Asp Ser Arg Glu His Val Asp Arg His Gly Cys Ile Val 
                645                 650                 655     


Lys Ile Val Arg Ser Ser Ser Ser Thr Gly Gln Lys Asn Phe Ser Ala 
            660                 665                 670         


Pro Pro Ala Ala Pro Pro Val Gln Cys Pro Pro Ser Thr Ser Trp Gln 
        675                 680                 685             


Pro Gln Ser His Pro Arg Gln Gly His Gly Thr Ser Pro Val Gly Asp 
    690                 695                 700                 


His Gly Ser Leu Val Arg Ile Pro Pro Pro Pro Ala His Glu Arg Ser 
705                 710                 715                 720 


Leu Ser Ala Tyr Gly Gly Gly Asn Arg Ala Ser Met Glu Phe Leu Arg 
                725                 730                 735     


Gln Glu Asp Thr Pro Gly Cys Arg Pro Pro Glu Gly Asn Leu Arg Asp 
            740                 745                 750         


Ser Asp Thr Ser Ile Ser Ile Pro Ser Val Asp His Glu Glu Leu Glu 
        755                 760                 765             


Arg Ser Phe Ser Gly Phe Ser Ile Ser Gln Ser Lys Glu Asn Leu Asp 
    770                 775                 780                 


Ala Leu Asn Ser Cys Tyr Ala Ala Val Ala Pro Cys Ala Lys Val Arg 
785                 790                 795                 800 


Pro Tyr Ile Ala Glu Gly Glu Ser Asp Thr Asp Ser Asp Leu Cys Thr 
                805                 810                 815     


Pro Cys Gly Pro Pro Pro Arg Ser Ala Thr Gly Glu Gly Pro Phe Gly 
            820                 825                 830         


Asp Val Gly Trp Ala Gly Pro Arg Lys 
        835                 840     


<210>  6281
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  6281

Met Val Gln Lys Ser Arg Asn Gly Gly Val Tyr Pro Gly Pro Ser Gly 
1               5                   10                  15      


Glu Lys Lys Leu Lys Val Gly Phe Val Gly Leu Asp Pro Gly Ala Pro 
            20                  25                  30          


Asp Ser Thr Arg Asp Gly Ala Leu Leu Ile Ala Gly Ser Glu Ala Pro 
        35                  40                  45              


Lys Arg Gly Ser Ile Leu Ser Lys Pro Arg Ala Gly Gly Ala Gly Ala 
    50                  55                  60                  


Gly Lys Pro Pro Lys Arg Asn Ala Phe Tyr Arg Lys Leu Gln Asn Phe 
65                  70                  75                  80  


Leu Tyr Asn Val Leu Glu Arg Pro Arg Gly Trp Ala Phe Ile Tyr His 
                85                  90                  95      


Ala Tyr Val Phe Leu Leu Val Phe Ser Cys Leu Val Leu Ser Val Phe 
            100                 105                 110         


Ser Thr Ile Lys Glu Tyr Glu Lys Ser Ser Glu Gly Ala Leu Tyr Ile 
        115                 120                 125             


Leu Glu Ile Val Thr Ile Val Val Phe Gly Val Glu Tyr Phe Val Arg 
    130                 135                 140                 


Ile Trp Ala Ala Gly Cys Cys Cys Arg Tyr Arg Gly Trp Arg Gly Arg 
145                 150                 155                 160 


Leu Lys Phe Ala Arg Lys Pro Phe Cys Val Ile Asp Ile Met Val Leu 
                165                 170                 175     


Ile Ala Ser Ile Ala Val Leu Ala Ala Gly Ser Gln Gly Asn Val Phe 
            180                 185                 190         


Ala Thr Ser Ala Leu Arg Ser Leu Arg Phe Leu Gln Ile Leu Arg Met 
        195                 200                 205             


Ile Arg Met Asp Arg Arg Gly Gly Thr Trp Lys Leu Leu Gly Ser Val 
    210                 215                 220                 


Val Tyr Ala His Ser Lys Glu Leu Val Thr Ala Trp Tyr Ile Gly Phe 
225                 230                 235                 240 


Leu Cys Leu Ile Leu Ala Ser Phe Leu Val Tyr Leu Ala Glu Lys Gly 
                245                 250                 255     


Glu Asn Asp His Phe Asp Thr Tyr Ala Asp Ala Leu Trp Trp Gly Leu 
            260                 265                 270         


Ile Thr Leu Thr Thr Ile Gly Tyr Gly Asp Lys Tyr Pro Gln Thr Trp 
        275                 280                 285             


Asn Gly Arg Leu Leu Ala Ala Thr Phe Thr Leu Ile Gly Val Ser Phe 
    290                 295                 300                 


Phe Ala Leu Pro Ala Gly Ile Leu Gly Ser Gly Phe Ala Leu Lys Val 
305                 310                 315                 320 


Gln Glu Gln His Arg Gln Lys His Phe Glu Lys Arg Arg Asn Pro Ala 
                325                 330                 335     


Ala Gly Leu Ile Gln Ser Ala Trp Arg Phe Tyr Ala Thr Asn Leu Ser 
            340                 345                 350         


Arg Thr Asp Leu His Ser Thr Trp Gln Tyr Tyr Glu Arg Thr Val Thr 
        355                 360                 365             


Val Pro Met Tyr Arg Tyr Arg Arg Arg Ala Pro Ala Thr Lys Gln Leu 
    370                 375                 380                 


Phe His Phe Leu Phe Ser Ile Cys Ser 
385                 390             


<210>  6282
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  6282

Met Val Ser Cys Glu Arg Arg Ala Ser Lys Ser Val Gly Gln Ile Leu 
1               5                   10                  15      


Leu Trp Asp Phe Gly Tyr Thr Cys Arg Leu Ser His Arg Arg Arg Asn 
            20                  25                  30          


Ser Thr Glu Ile Leu Ser Arg Asn Leu Pro Ala Leu Tyr Thr Gly Ile 
        35                  40                  45              


Lys Val Cys Glu Lys Arg Pro Ser Ile Asp Leu Cys Ile His His Cys 
    50                  55                  60                  


Ser Tyr Phe Gln Lys Cys Glu Thr Asn Lys Ile Cys Cys Ser Ala Phe 
65                  70                  75                  80  


Cys Gly Asn Ile Cys Met Ser Ile Leu 
                85                  


<210>  6283
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  6283

Met Lys Leu Asp Met Thr Gly Asp Cys Thr Pro Val Leu Val Leu Met 
1               5                   10                  15      


Ala Ala Val Leu Thr Val Thr Gly Ala Val Pro Val Ala Arg Leu His 
            20                  25                  30          


Gly Ala Leu Pro Asp Ala Arg Gly Cys His Ile Ala Gln Phe Lys Ser 
        35                  40                  45              


Leu Ser Pro Gln Glu Leu Gln Ala Phe Lys Arg Ala Lys Asp Ala Leu 
    50                  55                  60                  


Glu Glu Ser Leu Leu Leu Lys Asp Cys Arg Cys His Ser Arg Leu Phe 
65                  70                  75                  80  


Pro Arg Thr Trp Asp Leu Arg Gln Leu Gln Val Arg Glu Arg Pro Met 
                85                  90                  95      


Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val Leu Glu Ala Thr 
            100                 105                 110         


Ala Asp Thr Asp Pro Ala Leu Val Asp Val Leu Asp Gln Pro Leu His 
        115                 120                 125             


Thr Leu His His Ile Leu Ser Gln Phe Arg Ala Cys Ile Gln Pro Gln 
    130                 135                 140                 


Pro Thr Ala Gly Pro Arg Thr Arg Gly Arg Leu His His Trp Leu Tyr 
145                 150                 155                 160 


Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser Pro Gly Cys Leu Glu Ala 
                165                 170                 175     


Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu Asn Cys 
            180                 185                 190         


Val Ala Ser Gly Asp Leu Cys Val 
        195                 200 


<210>  6284
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  6284

Met Ala Ala Ala Trp Thr Val Val Leu Val Thr Leu Val Leu Gly Leu 
1               5                   10                  15      


Ala Val Ala Gly Pro Val Pro Thr Ser Lys Pro Thr Thr Thr Gly Lys 
            20                  25                  30          


Gly Cys His Ile Gly Arg Phe Lys Ser Leu Ser Pro Gln Glu Leu Ala 
        35                  40                  45              


Ser Phe Lys Lys Ala Arg Asp Ala Leu Glu Glu Ser Leu Lys Leu Lys 
    50                  55                  60                  


Asn Trp Ser Cys Ser Ser Pro Val Phe Pro Gly Asn Trp Asp Leu Arg 
65                  70                  75                  80  


Leu Leu Gln Val Arg Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala 
                85                  90                  95      


Leu Thr Leu Lys Val Leu Glu Ala Ala Ala Gly Pro Ala Leu Glu Asp 
            100                 105                 110         


Val Leu Asp Gln Pro Leu His Thr Leu His His Ile Leu Ser Gln Leu 
        115                 120                 125             


Gln Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly 
    130                 135                 140                 


Arg Leu His His Trp Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu 
145                 150                 155                 160 


Ser Ala Gly Cys Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu 
                165                 170                 175     


Leu Thr Arg Asp Leu Lys Tyr Val Ala Asp Gly Asn Leu Cys Leu Arg 
            180                 185                 190         


Thr Ser Thr His Pro Glu Ser Thr 
        195                 200 


<210>  6285
<211>  641
<212>  PRT
<213>  Homo sapiens

<400>  6285

Met Ala Glu Ala Pro Pro Arg Arg Leu Gly Leu Gly Pro Pro Pro Gly 
1               5                   10                  15      


Asp Ala Pro Arg Ala Glu Leu Val Ala Leu Thr Ala Val Gln Ser Glu 
            20                  25                  30          


Gln Gly Glu Ala Gly Gly Gly Gly Ser Pro Arg Arg Leu Gly Leu Leu 
        35                  40                  45              


Gly Ser Pro Leu Pro Pro Gly Ala Pro Leu Pro Gly Pro Gly Ser Gly 
    50                  55                  60                  


Ser Gly Ser Ala Cys Gly Gln Arg Ser Ser Ala Ala His Lys Arg Tyr 
65                  70                  75                  80  


Arg Arg Leu Gln Asn Trp Val Tyr Asn Val Leu Glu Arg Pro Arg Gly 
                85                  90                  95      


Trp Ala Phe Val Tyr His Val Phe Ile Phe Leu Leu Val Phe Ser Cys 
            100                 105                 110         


Leu Val Leu Ser Val Leu Ser Thr Ile Gln Glu His Gln Glu Leu Ala 
        115                 120                 125             


Asn Glu Cys Leu Leu Ile Leu Glu Phe Val Met Ile Val Val Phe Gly 
    130                 135                 140                 


Leu Glu Tyr Ile Val Arg Val Trp Ser Ala Gly Cys Cys Cys Arg Tyr 
145                 150                 155                 160 


Arg Gly Trp Gln Gly Arg Phe Arg Phe Ala Arg Lys Pro Phe Cys Val 
                165                 170                 175     


Ile Asp Phe Ile Val Phe Val Ala Ser Val Ala Val Ile Ala Ala Gly 
            180                 185                 190         


Thr Gln Gly Asn Ile Phe Ala Thr Ser Ala Leu Arg Ser Met Arg Phe 
        195                 200                 205             


Leu Gln Ile Leu Arg Met Val Arg Met Asp Arg Arg Gly Gly Thr Trp 
    210                 215                 220                 


Lys Leu Leu Gly Ser Val Val Tyr Ala His Ser Lys Glu Leu Ile Thr 
225                 230                 235                 240 


Ala Trp Tyr Ile Gly Phe Leu Val Leu Ile Phe Ala Ser Phe Leu Val 
                245                 250                 255     


Tyr Leu Ala Glu Lys Asp Ala Asn Ser Asp Phe Ser Ser Tyr Ala Asp 
            260                 265                 270         


Ser Leu Trp Trp Gly Thr Ile Thr Leu Thr Thr Ile Gly Tyr Gly Asp 
        275                 280                 285             


Lys Thr Pro His Thr Trp Leu Gly Arg Val Leu Ala Ala Gly Phe Ala 
    290                 295                 300                 


Leu Leu Gly Ile Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu Gly Ser 
305                 310                 315                 320 


Gly Phe Ala Leu Lys Val Gln Glu Gln His Arg Gln Lys His Phe Glu 
                325                 330                 335     


Lys Arg Arg Met Pro Ala Ala Asn Leu Ile Gln Ala Ala Trp Arg Leu 
            340                 345                 350         


Tyr Ser Thr Asp Met Ser Arg Ala Tyr Leu Thr Ala Thr Trp Tyr Tyr 
        355                 360                 365             


Tyr Asp Ser Ile Leu Pro Ser Phe Ser Ser Arg Met Gly Ile Lys Asp 
    370                 375                 380                 


Arg Ile Arg Met Gly Ser Ser Gln Arg Arg Thr Gly Pro Ser Lys Gln 
385                 390                 395                 400 


His Leu Ala Pro Pro Thr Met Pro Thr Ser Pro Ser Ser Glu Gln Val 
                405                 410                 415     


Gly Glu Ala Thr Ser Pro Thr Lys Val Gln Lys Ser Trp Ser Phe Asn 
            420                 425                 430         


Asp Arg Thr Arg Phe Arg Ala Ser Leu Arg Leu Lys Pro Arg Thr Ser 
        435                 440                 445             


Ala Glu Asp Ala Pro Ser Glu Glu Val Ala Glu Glu Lys Ser Tyr Gln 
    450                 455                 460                 


Cys Glu Leu Thr Val Asp Asp Ile Met Pro Ala Val Lys Thr Val Ile 
465                 470                 475                 480 


Arg Ser Ile Arg Ile Leu Lys Phe Leu Val Ala Lys Arg Lys Phe Lys 
                485                 490                 495     


Glu Thr Leu Arg Pro Tyr Asp Val Lys Asp Val Ile Glu Gln Tyr Ser 
            500                 505                 510         


Ala Gly His Leu Asp Met Leu Gly Arg Ile Lys Ser Leu Gln Thr Arg 
        515                 520                 525             


Val Asp Gln Ile Val Gly Arg Gly Pro Gly Asp Arg Lys Ala Arg Glu 
    530                 535                 540                 


Lys Gly Asp Lys Gly Pro Ser Asp Ala Glu Val Val Asp Glu Ile Ser 
545                 550                 555                 560 


Met Met Gly Arg Val Val Lys Val Glu Lys Gln Val Gln Ser Ile Glu 
                565                 570                 575     


His Lys Leu Asp Leu Leu Leu Gly Phe Tyr Ser Arg Cys Leu Arg Ser 
            580                 585                 590         


Gly Thr Ser Ala Ser Leu Gly Ala Val Gln Val Pro Leu Phe Asp Pro 
        595                 600                 605             


Asp Ile Thr Ser Asp Tyr His Ser Pro Val Asp His Glu Asp Ile Ser 
    610                 615                 620                 


Val Ser Ala Gln Thr Leu Ser Ile Ser Arg Ser Val Ser Thr Asn Met 
625                 630                 635                 640 


Asp 
    


<210>  6286
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  6286

Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val 
    50                  55                  60                  


Leu Pro Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu 
65                  70                  75                  80  


Gly Ile Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys 
                85                  90                  95      


Ser Asn Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile 
            100                 105                 110         


Val Asp Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly 
        115                 120                 125             


Thr Cys Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His 
    130                 135                 140                 


Leu Asp Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys 
145                 150                 155                 160 


Glu Gln Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser 
                165                 170                 175     


Glu Leu Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe 
            180                 185                 190         


Ser Cys Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr 
        195                 200                 205             


Ala Pro Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val 
    210                 215                 220                 


Gln Leu Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr 
225                 230                 235                 240 


Val Thr Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His 
                245                 250                 255     


Trp Met Lys Asp Val Ser Asp Leu Glu Arg Gly Ala Gly Arg Thr Arg 
            260                 265                 270         


Arg Gly Gly Ala Asn Cys Arg Leu Cys Gly Arg Ile Arg Ala Gly Asn 
        275                 280                 285             


Ser Ser Pro Gly Pro Gly Asp Pro Gly Arg Pro Gly Asp Ser Arg Pro 
    290                 295                 300                 


Ala His Trp Gly His Leu Val Ala Lys Ala Ala Thr Pro Arg Arg Gly 
305                 310                 315                 320 


Glu Glu Gly Pro Arg Lys Pro Gly Gly Arg Gly Gly Ala Cys Arg Thr 
                325                 330                 335     


Glu Ser Val Gly Gly Thr 
            340         


<210>  6287
<211>  636
<212>  PRT
<213>  Homo sapiens

<400>  6287

Met Ala Ala Gly Val Ala Ala Trp Leu Pro Phe Ala Arg Ala Ala Ala 
1               5                   10                  15      


Ile Gly Trp Met Pro Val Ala Asn Cys Pro Met Pro Leu Ala Pro Ala 
            20                  25                  30          


Asp Lys Asn Lys Arg Gln Asp Glu Leu Ile Val Leu Asn Val Ser Gly 
        35                  40                  45              


Arg Arg Phe Gln Thr Trp Arg Thr Thr Leu Glu Arg Tyr Pro Asp Thr 
    50                  55                  60                  


Leu Leu Gly Ser Thr Glu Lys Glu Phe Phe Phe Asn Glu Asp Thr Lys 
65                  70                  75                  80  


Glu Tyr Phe Phe Asp Arg Asp Pro Glu Val Phe Arg Cys Val Leu Asn 
                85                  90                  95      


Phe Tyr Arg Thr Gly Lys Leu His Tyr Pro Arg Tyr Glu Cys Ile Ser 
            100                 105                 110         


Ala Tyr Asp Asp Glu Leu Ala Phe Tyr Gly Ile Leu Pro Glu Ile Ile 
        115                 120                 125             


Gly Asp Cys Cys Tyr Glu Glu Tyr Lys Asp Arg Lys Arg Glu Asn Ala 
    130                 135                 140                 


Glu Arg Leu Met Asp Asp Asn Asp Ser Glu Asn Asn Gln Glu Ser Met 
145                 150                 155                 160 


Pro Ser Leu Ser Phe Arg Gln Thr Met Trp Arg Ala Phe Glu Asn Pro 
                165                 170                 175     


His Thr Ser Thr Leu Ala Leu Val Phe Tyr Tyr Val Thr Gly Phe Phe 
            180                 185                 190         


Ile Ala Val Ser Val Ile Thr Asn Val Val Glu Thr Val Pro Cys Gly 
        195                 200                 205             


Thr Val Pro Gly Ser Lys Glu Leu Pro Cys Gly Glu Arg Tyr Ser Val 
    210                 215                 220                 


Ala Phe Phe Cys Leu Asp Thr Ala Cys Val Met Ile Phe Thr Val Glu 
225                 230                 235                 240 


Tyr Leu Leu Arg Leu Phe Ala Ala Pro Ser Arg Tyr Arg Phe Ile Arg 
                245                 250                 255     


Ser Val Met Ser Ile Ile Asp Val Val Ala Ile Met Pro Tyr Tyr Ile 
            260                 265                 270         


Gly Leu Val Met Thr Asn Asn Glu Asp Val Ser Gly Ala Phe Val Thr 
        275                 280                 285             


Leu Arg Val Phe Arg Val Phe Arg Ile Phe Lys Phe Ser Arg His Ser 
    290                 295                 300                 


Gln Gly Leu Arg Ile Leu Gly Tyr Thr Leu Lys Ser Cys Ala Ser Glu 
305                 310                 315                 320 


Leu Gly Phe Leu Leu Phe Ser Leu Thr Met Ala Ile Ile Ile Phe Ala 
                325                 330                 335     


Thr Val Met Phe Tyr Ala Glu Lys Gly Ser Ser Ala Ser Lys Phe Thr 
            340                 345                 350         


Ser Ile Pro Ala Ser Phe Trp Tyr Thr Ile Val Thr Met Thr Thr Leu 
        355                 360                 365             


Gly Tyr Gly Asp Met Val Pro Lys Thr Ile Ala Gly Lys Ile Phe Gly 
    370                 375                 380                 


Ser Ile Cys Ser Leu Ser Gly Val Leu Val Ile Ala Leu Pro Val Pro 
385                 390                 395                 400 


Val Ile Val Ser Asn Phe Ser Arg Ile Tyr His Gln Asn Gln Arg Ala 
                405                 410                 415     


Asp Lys Arg Arg Ala Gln Lys Lys Ala Arg Leu Ala Arg Ile Arg Val 
            420                 425                 430         


Ala Lys Thr Gly Ser Ser Asn Ala Tyr Leu His Ser Lys Arg Asn Gly 
        435                 440                 445             


Leu Leu Asn Glu Ala Leu Glu Leu Thr Gly Thr Pro Glu Glu Glu His 
    450                 455                 460                 


Met Gly Lys Thr Thr Ser Leu Ile Glu Ser Gln His His His Leu Leu 
465                 470                 475                 480 


His Cys Leu Glu Lys Thr Thr Asn His Glu Phe Ile Asp Glu Gln Met 
                485                 490                 495     


Phe Glu Gln Asn Cys Met Glu Ser Ser Met Gln Asn Tyr Pro Ser Thr 
            500                 505                 510         


Arg Ser Pro Ser Leu Ser Ser His Pro Gly Leu Thr Thr Thr Cys Cys 
        515                 520                 525             


Ser Arg Arg Ser Lys Lys Thr Thr His Leu Pro Asn Ser Asn Leu Pro 
    530                 535                 540                 


Ala Thr Arg Leu Arg Ser Met Gln Glu Leu Ser Thr Ile His Ile Gln 
545                 550                 555                 560 


Gly Ser Glu Gln Pro Ser Leu Thr Thr Ser Arg Ser Ser Leu Asn Leu 
                565                 570                 575     


Lys Ala Asp Asp Gly Leu Arg Pro Asn Cys Lys Thr Ser Gln Ile Thr 
            580                 585                 590         


Thr Ala Ile Ile Ser Ile Pro Thr Pro Pro Ala Leu Thr Pro Glu Gly 
        595                 600                 605             


Glu Ser Arg Pro Pro Pro Ala Ser Pro Gly Pro Asn Thr Asn Ile Pro 
    610                 615                 620                 


Ser Ile Ala Ser Asn Val Val Lys Val Ser Ala Leu 
625                 630                 635     


<210>  6288
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  6288

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Lys Pro 
                85                  90                  95      


Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala 
            100                 105                 110         


Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly 
        115                 120                 125             


Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln 
    130                 135                 140                 


Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro 
145                 150                 155                 160 


Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile Ser 
                165                 170                 175     


Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu Ala 
            180                 185                 190         


Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu Met 
        195                 200                 205             


Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg Asp 
    210                 215                 220                 


Glu Asp Leu Glu Asn Cys Ser His His Leu 
225                 230                 


<210>  6289
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  6289

Met Ser Thr Leu Ser Asn Phe Thr Gln Thr Leu Glu Asp Val Phe Arg 
1               5                   10                  15      


Arg Ile Phe Ile Thr Tyr Met Asp Asn Trp Arg Gln Asn Thr Thr Ala 
            20                  25                  30          


Glu Gln Glu Ala Leu Gln Ala Lys Val Asp Ala Glu Asn Phe Tyr Tyr 
        35                  40                  45              


Val Ile Leu Tyr Leu Met Val Met Ile Gly Met Phe Ser Phe Ile Ile 
    50                  55                  60                  


Val Ala Ile Leu Val Ser Thr Val Lys Ser Lys Arg Arg Glu His Ser 
65                  70                  75                  80  


Asn Asp Pro Tyr His Gln Tyr Ile Val Glu Asp Trp Gln Glu Lys Tyr 
                85                  90                  95      


Lys Ser Gln Ile Leu Asn Leu Glu Glu Ser Lys Ala Thr Ile His Glu 
            100                 105                 110         


Asn Ile Gly Ala Ala Gly Phe Lys Met Ser Pro 
        115                 120             


<210>  6290
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  6290

Met Lys Ser Leu Ser Leu Leu Leu Ala Val Ala Leu Gly Leu Ala Thr 
1               5                   10                  15      


Ala Val Ser Ala Gly Pro Ala Val Ile Glu Cys Trp Phe Val Glu Asp 
            20                  25                  30          


Ala Ser Gly Lys Gly Leu Ala Lys Arg Pro Gly Ala Leu Leu Leu Arg 
        35                  40                  45              


Gln Gly Pro Gly Glu Pro Pro Pro Arg Pro Asp Leu Asp Pro Glu Leu 
    50                  55                  60                  


Tyr Leu Ser Val His Asp Pro Ala Gly Ala Leu Gln Ala Ala Phe Arg 
65                  70                  75                  80  


Arg Tyr Pro Arg Gly Ala Pro Ala Pro His Cys Glu Met Ser Arg Phe 
                85                  90                  95      


Val Pro Leu Pro Ala Ser Ala Lys Trp Ala Ser Gly Leu Thr Pro Ala 
            100                 105                 110         


Gln Asn Cys Pro Arg Ala Leu Asp Gly Ala Trp Leu Met Val Ser Ile 
        115                 120                 125             


Ser Ser Pro Val Leu Ser Leu Ser Ser Leu Leu Arg Pro Gln Pro Glu 
    130                 135                 140                 


Pro Gln Gln Glu Pro Val Leu Ile Thr Met Ala Thr Val Val Leu Thr 
145                 150                 155                 160 


Val Leu Thr His Thr Pro Ala Pro Arg Val Arg Leu Gly Gln Asp Ala 
                165                 170                 175     


Leu Leu Asp Leu Ser Phe Ala Tyr Met Pro Pro Thr Ser Glu Ala Ala 
            180                 185                 190         


Ser Ser Leu Ala Pro Gly Pro Pro Pro Phe Gly Leu Glu Trp Arg Arg 
        195                 200                 205             


Gln His Leu Gly Lys Gly His Leu Leu Leu Ala Ala Thr Pro Gly Leu 
    210                 215                 220                 


Asn Gly Gln Met Pro Ala Ala Gln Glu Gly Ala Val Ala Phe Ala Ala 
225                 230                 235                 240 


Trp Asp Asp Asp Glu Pro Trp Gly Pro Trp Thr Gly Asn Gly Thr Phe 
                245                 250                 255     


Trp Leu Pro Thr Val Gln Pro Phe Gln Glu Gly Thr Tyr Leu Ala Thr 
            260                 265                 270         


Ile His Leu Pro Tyr Leu Gln Gly Gln Val Thr Leu Glu Leu Ala Val 
        275                 280                 285             


Tyr Lys Pro Pro Lys Val Ser Leu Met Pro Ala Thr Leu Ala Arg Ala 
    290                 295                 300                 


Ala Pro Gly Glu Ala Pro Pro Glu Leu Leu Cys Leu Val Ser His Phe 
305                 310                 315                 320 


Tyr Pro Ser Gly Gly Leu Glu Val Glu Trp Glu Leu Arg Gly Gly Pro 
                325                 330                 335     


Gly Gly Arg Ser Gln Lys Ala Glu Gly Gln Arg Trp Leu Ser Ala Leu 
            340                 345                 350         


Arg His His Ser Asp Gly Ser Val Ser Leu Ser Gly His Leu Gln Pro 
        355                 360                 365             


Pro Pro Val Thr Thr Glu Gln His Gly Ala Arg Tyr Ala Cys Arg Ile 
    370                 375                 380                 


His His Pro Ser Leu Pro Ala Ser Gly Arg Ser Ala Glu Val Thr Leu 
385                 390                 395                 400 


Glu Val Ala Gly Leu Ser Gly Pro Ser Leu Glu Asp Ser Val Gly Leu 
                405                 410                 415     


Phe Leu Ser Ala Phe Leu Leu Leu Gly Leu Phe Lys Ala Leu Gly Trp 
            420                 425                 430         


Ala Ala Val Tyr Leu Ser Thr Cys Lys Asp Ser Lys Lys Val Gln Cys 
        435                 440                 445             


Ser Thr Ser Leu Tyr Leu Ser Leu Val Thr Leu Ser Pro His Pro Ile 
    450                 455                 460                 


Ser Lys Pro Met Glu Gly Gly Cys Trp Cys Gly Arg Gln Asn Leu Gly 
465                 470                 475                 480 


Leu Glu Phe Thr Leu Ile Trp Val Lys Thr Trp His Tyr Ile Leu Thr 
                485                 490                 495     


Val Gly Leu Phe Glu His Ala Thr 
            500                 


<210>  6291
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  6291

Met Lys Ser Leu Ser Leu Leu Leu Ala Val Ala Leu Gly Leu Ala Thr 
1               5                   10                  15      


Ala Val Ser Ala Gly Pro Ala Val Ile Glu Cys Trp Phe Val Glu Asp 
            20                  25                  30          


Ala Ser Gly Lys Gly Leu Ala Lys Arg Pro Gly Ala Leu Leu Leu Arg 
        35                  40                  45              


Gln Gly Pro Gly Glu Pro Pro Pro Arg Pro Asp Leu Asp Pro Glu Leu 
    50                  55                  60                  


Tyr Leu Ser Val His Val Val Leu Thr Val Leu Thr His Thr Pro Ala 
65                  70                  75                  80  


Pro Arg Val Arg Leu Gly Gln Asp Ala Leu Leu Asp Leu Ser Phe Ala 
                85                  90                  95      


Tyr Met Pro Pro Thr Ser Glu Ala Ala Ser Ser Leu Ala Pro Gly Pro 
            100                 105                 110         


Pro Pro Phe Gly Leu Glu Trp Arg Arg Gln His Leu Gly Lys Gly His 
        115                 120                 125             


Leu Leu Leu Ala Ala Thr Pro Gly Leu Asn Gly Gln Met Pro Ala Ala 
    130                 135                 140                 


Gln Glu Gly Ala Val Ala Phe Ala Ala Trp Asp Asp Asp Glu Pro Trp 
145                 150                 155                 160 


Gly Pro Trp Thr Gly Asn Gly Thr Phe Trp Leu Pro Thr Val Gln Pro 
                165                 170                 175     


Phe Gln Glu Gly Thr Tyr Leu Ala Thr Ile His Leu Pro Tyr Leu Gln 
            180                 185                 190         


Gly Gln Val Thr Leu Glu Leu Ala Val Tyr Lys Pro Pro Lys Val Ser 
        195                 200                 205             


Leu Met Pro Ala Thr Leu Ala Arg Ala Ala Pro Gly Glu Ala Pro Pro 
    210                 215                 220                 


Glu Leu Leu Cys Leu Val Ser His Phe Tyr Pro Ser Gly Gly Leu Glu 
225                 230                 235                 240 


Val Glu Trp Glu Leu Arg Gly Gly Pro Gly Gly Arg Ser Gln Lys Ala 
                245                 250                 255     


Glu Gly Gln Arg Trp Leu Ser Ala Leu Arg His His Ser Asp Gly Ser 
            260                 265                 270         


Val Ser Leu Ser Gly His Leu Gln Pro Pro Pro Val Thr Thr Glu Gln 
        275                 280                 285             


His Gly Ala Arg Tyr Ala Cys Arg Ile His His Pro Ser Leu Pro Ala 
    290                 295                 300                 


Ser Gly Arg Ser Ala Glu Val Thr Leu Glu Val Ala Gly Leu Ser Gly 
305                 310                 315                 320 


Pro Ser Leu Glu Asp Ser Val Gly Leu Phe Leu Ser Ala Phe Leu Leu 
                325                 330                 335     


Leu Gly Leu Phe Lys Ala Leu Gly Trp Ala Ala Val Tyr Leu Ser Thr 
            340                 345                 350         


Cys Lys Asp Ser Lys Lys Lys Ala Glu 
        355                 360     


<210>  6292
<211>  438
<212>  PRT
<213>  Homo sapiens

<400>  6292

Met Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Thr Trp Leu 
1               5                   10                  15      


Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 
            20                  25                  30          


Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
        35                  40                  45              


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
    50                  55                  60                  


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
65                  70                  75                  80  


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
                85                  90                  95      


Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
            100                 105                 110         


Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 
        115                 120                 125             


Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 
    130                 135                 140                 


Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 
145                 150                 155                 160 


Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
                165                 170                 175     


Glu Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp Cys Asn Cys Leu 
            180                 185                 190         


Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser Pro His 
        195                 200                 205             


Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Thr Trp Glu 
    210                 215                 220                 


Asp Ser Glu Gly Thr Glu Gly Ser Ser Leu Leu Pro Gly Glu Gln Pro 
225                 230                 235                 240 


Leu His Thr Val Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg Ser 
                245                 250                 255     


Thr Cys Gln Ser Phe Glu Pro Pro Glu Thr Pro Val Val Lys Asp Ser 
            260                 265                 270         


Thr Ile Gly Gly Ser Pro Gln Pro Arg Pro Ser Val Gly Ala Phe Asn 
        275                 280                 285             


Pro Gly Met Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn Trp Val 
    290                 295                 300                 


Pro Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro Gln Gly 
305                 310                 315                 320 


Thr Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln Thr Glu 
                325                 330                 335     


Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro Leu Pro Ala 
            340                 345                 350         


Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Thr Gly His Glu Arg Gln 
        355                 360                 365             


Ser Glu Gly Ser Ser Ser Pro Gln Leu Gln Glu Ser Val Phe His Leu 
    370                 375                 380                 


Leu Val Pro Ser Val Ile Leu Val Leu Leu Ala Val Gly Gly Leu Leu 
385                 390                 395                 400 


Phe Tyr Arg Trp Arg Arg Arg Ser His Gln Glu Pro Gln Arg Ala Asp 
                405                 410                 415     


Ser Pro Leu Glu Gln Pro Glu Gly Ser Pro Leu Thr Gln Asp Asp Arg 
            420                 425                 430         


Gln Val Glu Leu Pro Val 
        435             


<210>  6293
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  6293

Met Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Thr Trp Leu 
1               5                   10                  15      


Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 
            20                  25                  30          


Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
        35                  40                  45              


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
    50                  55                  60                  


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
65                  70                  75                  80  


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
                85                  90                  95      


Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
            100                 105                 110         


Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 
        115                 120                 125             


Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 
    130                 135                 140                 


Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 
145                 150                 155                 160 


Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
                165                 170                 175     


Glu Cys Ser Ser Gln Gly His Glu Arg Gln Ser Glu Gly Ser Ser Ser 
            180                 185                 190         


Pro Gln Leu Gln Glu Ser Val Phe His Leu Leu Val Pro Ser Val Ile 
        195                 200                 205             


Leu Val Leu Leu Ala Val Gly Gly Leu Leu Phe Tyr Arg Trp Arg Arg 
    210                 215                 220                 


Arg Ser His Gln Glu Pro Gln Arg Ala Asp Ser Pro Leu Glu Gln Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Leu Thr Gln Asp Asp Arg Gln Val Glu Leu Pro Val 
                245                 250                 255     


<210>  6294
<211>  554
<212>  PRT
<213>  Homo sapiens

<400>  6294

Met Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Thr Trp Leu 
1               5                   10                  15      


Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 
            20                  25                  30          


Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
        35                  40                  45              


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
    50                  55                  60                  


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
65                  70                  75                  80  


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
                85                  90                  95      


Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
            100                 105                 110         


Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 
        115                 120                 125             


Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 
    130                 135                 140                 


Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 
145                 150                 155                 160 


Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
                165                 170                 175     


Glu Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp Cys Asn Cys Leu 
            180                 185                 190         


Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser Pro His 
        195                 200                 205             


Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Thr Trp Glu 
    210                 215                 220                 


Asp Ser Glu Gly Thr Glu Gly Ser Ser Leu Leu Pro Gly Glu Gln Pro 
225                 230                 235                 240 


Leu His Thr Val Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg Ser 
                245                 250                 255     


Thr Cys Gln Ser Phe Glu Pro Pro Glu Thr Pro Val Val Lys Asp Ser 
            260                 265                 270         


Thr Ile Gly Gly Ser Pro Gln Pro Arg Pro Ser Val Gly Ala Phe Asn 
        275                 280                 285             


Pro Gly Met Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn Trp Val 
    290                 295                 300                 


Pro Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro Gln Gly 
305                 310                 315                 320 


Thr Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln Thr Glu 
                325                 330                 335     


Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro Leu Pro Ala 
            340                 345                 350         


Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Thr Gly Thr Ala Leu Pro 
        355                 360                 365             


Arg Val Gly Pro Val Arg Pro Thr Gly Gln Asp Trp Asn His Thr Pro 
    370                 375                 380                 


Gln Lys Thr Asp His Pro Ser Ala Leu Leu Arg Asp Pro Pro Glu Pro 
385                 390                 395                 400 


Gly Ser Pro Arg Ile Ser Ser Leu Arg Pro Gln Gly Leu Ser Asn Pro 
                405                 410                 415     


Ser Thr Leu Ser Ala Gln Pro Gln Leu Ser Arg Ser His Ser Ser Gly 
            420                 425                 430         


Ser Val Leu Pro Leu Gly Glu Leu Glu Gly Arg Arg Ser Thr Arg Asp 
        435                 440                 445             


Arg Arg Ser Pro Ala Glu Pro Glu Gly Gly Pro Ala Ser Glu Gly Ala 
    450                 455                 460                 


Ala Arg Pro Leu Pro Arg Phe Asn Ser Val Pro Leu Thr Asp Thr Gly 
465                 470                 475                 480 


His Glu Arg Gln Ser Glu Gly Ser Ser Ser Pro Gln Leu Gln Glu Ser 
                485                 490                 495     


Val Phe His Leu Leu Val Pro Ser Val Ile Leu Val Leu Leu Ala Val 
            500                 505                 510         


Gly Gly Leu Leu Phe Tyr Arg Trp Arg Arg Arg Ser His Gln Glu Pro 
        515                 520                 525             


Gln Arg Ala Asp Ser Pro Leu Glu Gln Pro Glu Gly Ser Pro Leu Thr 
    530                 535                 540                 


Gln Asp Asp Arg Gln Val Glu Leu Pro Val 
545                 550                 


<210>  6295
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  6295

Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Thr Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro 
    130                 135                 140                 


Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Thr Gln Lys Gly Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu 
                165                 170                 175     


Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Ile His 
            180                 185                 190         


Leu Cys Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Pro 
        195                 200                 205             


Gln Gly Glu Gly Ile Ser Gly Thr Phe Val Pro Gln Cys Leu His Gly 
    210                 215                 220                 


Tyr Tyr Ser Asn Thr Thr Thr Ser Gln Lys Leu Leu Asn Pro Trp Ile 
225                 230                 235                 240 


Leu Lys Thr 
            


<210>  6296
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  6296

Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 
65                  70                  75                  80  


Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 
                85                  90                  95      


Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu 
            100                 105                 110         


Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu 
        115                 120                 125             


Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala 
    130                 135                 140                 


Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu 
145                 150                 155                 160 


Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg 
                165                 170                 175     


Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu 
            180                 185                 190         


Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
        195                 200                 


<210>  6297
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  6297

Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Val Ser Glu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe 
65                  70                  75                  80  


Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu 
                85                  90                  95      


Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr 
            100                 105                 110         


Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln 
        115                 120                 125             


Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg 
    130                 135                 140                 


Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val 
145                 150                 155                 160 


Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
                165                 170     


<210>  6298
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  6298

Met Gly Thr Gln Ala Leu Gln Gly Phe Leu Phe Leu Leu Phe Leu Pro 
1               5                   10                  15      


Leu Leu Gln Pro Arg Gly Ala Ser Ala Gly Ser Leu His Ser Pro Gly 
            20                  25                  30          


Leu Ser Glu Cys Phe Gln Val Asn Gly Ala Asp Tyr Arg Gly His Gln 
        35                  40                  45              


Asn Arg Thr Gly Pro Arg Gly Ala Gly Arg Pro Cys Leu Phe Trp Asp 
    50                  55                  60                  


Gln Thr Gln Gln His Ser Tyr Ser Ser Ala Ser Asp Pro His Gly Arg 
65                  70                  75                  80  


Trp Gly Leu Gly Ala His Asn Phe Cys Arg Asn Pro Asp Gly Asp Val 
                85                  90                  95      


Gln Pro Trp Cys Tyr Val Ala Glu Thr Glu Glu Gly Ile Tyr Trp Arg 
            100                 105                 110         


Tyr Cys Asp Ile Pro Ser Cys His Met Pro Gly Tyr Leu Gly Cys Phe 
        115                 120                 125             


Val Asp Ser Gly Ala Pro Pro Ala Leu Ser Gly Pro Ser Gly Thr Ser 
    130                 135                 140                 


Thr Lys Leu Thr Val Gln Val Cys Leu Arg Phe Cys Arg Met Lys Gly 
145                 150                 155                 160 


Tyr Gln Leu Ala Gly Val Glu Ala Gly Tyr Ala Cys Phe Cys Gly Ser 
                165                 170                 175     


Glu Ser Asp Leu Ala Arg Gly Arg Leu Ala Pro Ala Thr Asp Cys Asp 
            180                 185                 190         


Gln Ile Cys Phe Gly His Pro Gly Gln Leu Cys Gly Gly Asp Gly Arg 
        195                 200                 205             


Leu Gly Val Tyr Glu Val Ser Val Gly Ser Cys Gln Gly Asn Trp Thr 
    210                 215                 220                 


Ala Pro Gln Gly Val Ile Tyr Ser Pro Asp Phe Pro Asp Glu Tyr Gly 
225                 230                 235                 240 


Pro Asp Arg Asn Cys Ser Trp Ala Leu Gly Pro Pro Gly Ala Ala Leu 
                245                 250                 255     


Glu Leu Thr Phe Arg Leu Phe Glu Leu Ala Asp Pro Arg Asp Arg Leu 
            260                 265                 270         


Glu Leu Arg Asp Ala Ala Ser Gly Ser Leu Leu Arg Ala Phe Asp Gly 
        275                 280                 285             


Ala Arg Pro Pro Pro Ser Gly Pro Leu Arg Leu Gly Thr Ala Ala Leu 
    290                 295                 300                 


Leu Leu Thr Phe Arg Ser Asp Ala Arg Gly His Ala Gln Gly Phe Ala 
305                 310                 315                 320 


Leu Thr Tyr Arg Gly Leu Gln Asp Ala Ala Glu Asp Pro Glu Ala Pro 
                325                 330                 335     


Glu Gly Ser Ala Gln Thr Pro Ala Ala Pro Leu Asp Gly Ala Asn Val 
            340                 345                 350         


Ser Cys Ser Pro Arg Pro Gly Ala Pro Pro Ala Ala Ile Gly Ala Arg 
        355                 360                 365             


Val Phe Ser Thr Val Thr Ala Val Ser Val Leu Leu Leu Leu Leu Leu 
    370                 375                 380                 


Gly Leu Leu Arg Pro Leu Arg Arg Arg Ser Cys Leu Leu Ala Pro Gly 
385                 390                 395                 400 


Lys Gly Pro Pro Ala Leu Gly Ala Ser Arg Gly Pro Arg Arg Ser Trp 
                405                 410                 415     


Ala Val Trp Tyr Gln Gln Pro Arg Gly Val Ala Leu Pro Cys Ser Pro 
            420                 425                 430         


Gly Asp Pro Gln Ala Glu Gly Ser Ala Ala Gly Tyr Arg Pro Leu Ser 
        435                 440                 445             


Ala Ser Ser Gln Ser Ser Leu Arg Ser Leu Ile Ser Ala Leu 
    450                 455                 460         


<210>  6299
<211>  1642
<212>  PRT
<213>  Homo sapiens

<400>  6299

Met Ser Thr Ala Ile Arg Glu Val Gly Val Trp Arg Gln Thr Arg Thr 
1               5                   10                  15      


Leu Leu Leu Lys Asn Tyr Leu Ile Lys Cys Arg Thr Lys Lys Ser Ser 
            20                  25                  30          


Val Gln Glu Ile Leu Phe Pro Leu Phe Phe Leu Phe Trp Leu Ile Leu 
        35                  40                  45              


Ile Ser Met Met His Pro Asn Lys Lys Tyr Glu Glu Val Pro Asn Ile 
    50                  55                  60                  


Glu Leu Asn Pro Met Asp Lys Phe Thr Leu Ser Asn Leu Ile Leu Gly 
65                  70                  75                  80  


Tyr Thr Pro Val Thr Asn Ile Thr Ser Ser Ile Met Gln Lys Val Ser 
                85                  90                  95      


Thr Asp His Leu Pro Asp Val Ile Ile Thr Glu Glu Tyr Thr Asn Glu 
            100                 105                 110         


Lys Glu Met Leu Thr Ser Ser Leu Ser Lys Pro Ser Asn Phe Val Gly 
        115                 120                 125             


Val Val Phe Lys Asp Ser Met Ser Tyr Glu Leu Arg Phe Phe Pro Asp 
    130                 135                 140                 


Met Ile Pro Val Ser Ser Ile Tyr Met Asp Ser Arg Ala Gly Cys Ser 
145                 150                 155                 160 


Lys Ser Cys Glu Ala Ala Gln Tyr Trp Ser Ser Gly Phe Thr Val Leu 
                165                 170                 175     


Gln Ala Ser Ile Asp Ala Ala Ile Ile Gln Leu Lys Thr Asn Val Ser 
            180                 185                 190         


Leu Trp Lys Glu Leu Glu Ser Thr Lys Ala Val Ile Met Gly Glu Thr 
        195                 200                 205             


Ala Val Val Glu Ile Asp Thr Phe Pro Arg Gly Val Ile Leu Ile Tyr 
    210                 215                 220                 


Leu Val Ile Ala Phe Ser Pro Phe Gly Tyr Phe Leu Ala Ile His Ile 
225                 230                 235                 240 


Val Ala Glu Lys Glu Lys Lys Ile Lys Glu Phe Leu Lys Ile Met Gly 
                245                 250                 255     


Leu His Asp Thr Ala Phe Trp Leu Ser Trp Val Leu Leu Tyr Thr Ser 
            260                 265                 270         


Leu Ile Phe Leu Met Ser Leu Leu Met Ala Val Ile Ala Thr Ala Ser 
        275                 280                 285             


Leu Leu Phe Pro Gln Ser Ser Ser Ile Val Ile Phe Leu Leu Phe Phe 
    290                 295                 300                 


Leu Tyr Gly Leu Ser Ser Val Phe Phe Ala Leu Met Leu Thr Pro Leu 
305                 310                 315                 320 


Phe Lys Lys Ser Lys His Val Gly Ile Val Glu Phe Phe Val Thr Val 
                325                 330                 335     


Ala Phe Gly Phe Ile Gly Leu Met Ile Ile Leu Ile Glu Ser Phe Pro 
            340                 345                 350         


Lys Ser Leu Val Trp Leu Phe Ser Pro Phe Cys His Cys Thr Phe Val 
        355                 360                 365             


Ile Gly Ile Ala Gln Val Met His Leu Glu Asp Phe Asn Glu Gly Ala 
    370                 375                 380                 


Ser Phe Ser Asn Leu Thr Ala Gly Pro Tyr Pro Leu Ile Ile Thr Ile 
385                 390                 395                 400 


Ile Met Leu Thr Leu Asn Ser Ile Phe Tyr Val Leu Leu Ala Val Tyr 
                405                 410                 415     


Leu Asp Gln Val Ile Pro Gly Glu Phe Gly Leu Arg Arg Ser Ser Leu 
            420                 425                 430         


Tyr Phe Leu Lys Pro Ser Tyr Trp Ser Lys Ser Lys Arg Asn Tyr Glu 
        435                 440                 445             


Glu Leu Ser Glu Gly Asn Val Asn Gly Asn Ile Ser Phe Ser Glu Ile 
    450                 455                 460                 


Ile Glu Pro Val Ser Ser Glu Phe Val Gly Lys Glu Ala Ile Arg Ile 
465                 470                 475                 480 


Ser Gly Ile Gln Lys Thr Tyr Arg Lys Lys Gly Glu Asn Val Glu Ala 
                485                 490                 495     


Leu Arg Asn Leu Ser Phe Asp Ile Tyr Glu Gly Gln Ile Thr Ala Leu 
            500                 505                 510         


Leu Gly His Ser Gly Thr Gly Lys Ser Thr Leu Met Asn Ile Leu Cys 
        515                 520                 525             


Gly Leu Cys Pro Pro Ser Asp Gly Phe Ala Ser Ile Tyr Gly His Arg 
    530                 535                 540                 


Val Ser Glu Ile Asp Glu Met Phe Glu Ala Arg Lys Met Ile Gly Ile 
545                 550                 555                 560 


Cys Pro Gln Leu Asp Ile His Phe Asp Val Leu Thr Val Glu Glu Asn 
                565                 570                 575     


Leu Ser Ile Leu Ala Ser Ile Lys Gly Ile Pro Ala Asn Asn Ile Ile 
            580                 585                 590         


Gln Glu Val Gln Lys Val Leu Leu Asp Leu Asp Met Gln Thr Ile Lys 
        595                 600                 605             


Asp Asn Gln Ala Lys Lys Leu Ser Gly Gly Gln Lys Arg Lys Leu Ser 
    610                 615                 620                 


Leu Gly Ile Ala Val Leu Gly Asn Pro Lys Ile Leu Leu Leu Asp Glu 
625                 630                 635                 640 


Pro Thr Ala Gly Met Asp Pro Cys Ser Arg His Ile Val Trp Asn Leu 
                645                 650                 655     


Leu Lys Tyr Arg Lys Ala Asn Arg Val Thr Val Phe Ser Thr His Phe 
            660                 665                 670         


Met Asp Glu Ala Asp Ile Leu Ala Asp Arg Lys Ala Val Ile Ser Gln 
        675                 680                 685             


Gly Met Leu Lys Cys Val Gly Ser Ser Met Phe Leu Lys Ser Lys Trp 
    690                 695                 700                 


Gly Ile Gly Tyr Arg Leu Ser Met Tyr Ile Asp Lys Tyr Cys Ala Thr 
705                 710                 715                 720 


Glu Ser Leu Ser Ser Leu Val Lys Gln His Ile Pro Gly Ala Thr Leu 
                725                 730                 735     


Leu Gln Gln Asn Asp Gln Gln Leu Val Tyr Ser Leu Pro Phe Lys Asp 
            740                 745                 750         


Met Asp Lys Phe Ser Gly Leu Phe Ser Ala Leu Asp Ser His Ser Asn 
        755                 760                 765             


Leu Gly Val Ile Ser Tyr Gly Val Ser Met Thr Thr Leu Glu Asp Val 
    770                 775                 780                 


Phe Leu Lys Leu Glu Val Glu Ala Glu Ile Asp Gln Ala Asp Tyr Ser 
785                 790                 795                 800 


Val Phe Thr Gln Gln Pro Leu Glu Glu Glu Met Asp Ser Lys Ser Phe 
                805                 810                 815     


Asp Glu Met Glu Gln Ser Leu Leu Ile Leu Ser Glu Thr Lys Ala Ala 
            820                 825                 830         


Leu Val Ser Thr Met Ser Leu Trp Lys Gln Gln Met Tyr Thr Ile Ala 
        835                 840                 845             


Lys Phe His Phe Phe Thr Leu Lys Arg Glu Ser Lys Ser Val Arg Ser 
    850                 855                 860                 


Val Leu Leu Leu Leu Leu Ile Phe Phe Thr Val Gln Ile Phe Met Phe 
865                 870                 875                 880 


Leu Val His His Ser Phe Lys Asn Ala Val Val Pro Ile Lys Leu Val 
                885                 890                 895     


Pro Asp Leu Tyr Phe Leu Lys Pro Gly Asp Lys Pro His Lys Tyr Lys 
            900                 905                 910         


Thr Ser Leu Leu Leu Gln Asn Ser Ala Asp Ser Asp Ile Ser Asp Leu 
        915                 920                 925             


Ile Ser Phe Phe Thr Ser Gln Asn Ile Met Val Thr Met Ile Asn Asp 
    930                 935                 940                 


Ser Asp Tyr Val Ser Val Ala Pro His Ser Ala Ala Leu Asn Val Met 
945                 950                 955                 960 


His Ser Glu Lys Asp Tyr Val Phe Ala Ala Val Phe Asn Ser Thr Met 
                965                 970                 975     


Val Tyr Ser Leu Pro Ile Leu Val Asn Ile Ile Ser Asn Tyr Tyr Leu 
            980                 985                 990         


Tyr His Leu Asn Val Thr Glu Thr  Ile Gln Ile Trp Ser  Thr Pro Phe 
        995                 1000                 1005             


Phe Gln  Glu Ile Thr Asp Ile  Val Phe Lys Ile Glu  Leu Tyr Phe 
    1010                 1015                 1020             


Gln Ala  Ala Leu Leu Gly Ile  Ile Val Thr Ala Met  Pro Pro Tyr 
    1025                 1030                 1035             


Phe Ala  Met Glu Asn Ala Glu  Asn His Lys Ile Lys  Ala Tyr Thr 
    1040                 1045                 1050             


Gln Leu  Lys Leu Ser Gly Leu  Leu Pro Ser Ala Tyr  Trp Ile Gly 
    1055                 1060                 1065             


Gln Ala  Val Val Asp Ile Pro  Leu Phe Phe Ile Ile  Leu Ile Leu 
    1070                 1075                 1080             


Met Leu  Gly Ser Leu Leu Ala  Phe His Tyr Gly Leu  Tyr Phe Tyr 
    1085                 1090                 1095             


Thr Val  Lys Phe Leu Ala Val  Val Phe Cys Leu Ile  Gly Tyr Val 
    1100                 1105                 1110             


Pro Ser  Val Ile Leu Phe Thr  Tyr Ile Ala Ser Phe  Thr Phe Lys 
    1115                 1120                 1125             


Lys Ile  Leu Asn Thr Lys Glu  Phe Trp Ser Phe Ile  Tyr Ser Val 
    1130                 1135                 1140             


Ala Ala  Leu Ala Cys Ile Ala  Ile Thr Glu Ile Thr  Phe Phe Met 
    1145                 1150                 1155             


Gly Tyr  Thr Ile Ala Thr Ile  Leu His Tyr Ala Phe  Cys Ile Ile 
    1160                 1165                 1170             


Ile Pro  Ile Tyr Pro Leu Leu  Gly Cys Leu Ile Ser  Phe Ile Lys 
    1175                 1180                 1185             


Ile Ser  Trp Lys Asn Val Arg  Lys Asn Val Asp Thr  Tyr Asn Pro 
    1190                 1195                 1200             


Trp Asp  Arg Leu Ser Val Ala  Val Ile Ser Pro Tyr  Leu Gln Cys 
    1205                 1210                 1215             


Val Leu  Trp Ile Phe Leu Leu  Gln Tyr Tyr Glu Lys  Lys Tyr Gly 
    1220                 1225                 1230             


Gly Arg  Ser Ile Arg Lys Asp  Pro Phe Phe Arg Asn  Leu Ser Thr 
    1235                 1240                 1245             


Lys Ser  Lys Asn Arg Lys Leu  Pro Glu Pro Pro Asp  Asn Glu Asp 
    1250                 1255                 1260             


Glu Asp  Glu Asp Val Lys Ala  Glu Arg Leu Lys Val  Lys Glu Leu 
    1265                 1270                 1275             


Met Gly  Cys Gln Cys Cys Glu  Glu Lys Pro Ser Ile  Met Val Ser 
    1280                 1285                 1290             


Asn Leu  His Lys Glu Tyr Asp  Asp Lys Lys Asp Phe  Leu Leu Ser 
    1295                 1300                 1305             


Arg Lys  Val Lys Lys Val Ala  Thr Lys Tyr Ile Ser  Phe Cys Val 
    1310                 1315                 1320             


Lys Lys  Gly Glu Ile Leu Gly  Leu Leu Gly Pro Asn  Gly Ala Gly 
    1325                 1330                 1335             


Lys Ser  Thr Ile Ile Asn Ile  Leu Val Gly Asp Ile  Glu Pro Thr 
    1340                 1345                 1350             


Ser Gly  Gln Val Phe Leu Gly  Asp Tyr Ser Ser Glu  Thr Ser Glu 
    1355                 1360                 1365             


Asp Asp  Asp Ser Leu Lys Cys  Met Gly Tyr Cys Pro  Gln Ile Asn 
    1370                 1375                 1380             


Pro Leu  Trp Pro Asp Thr Thr  Leu Gln Glu His Phe  Glu Ile Tyr 
    1385                 1390                 1395             


Gly Ala  Val Lys Gly Met Ser  Ala Ser Asp Met Lys  Glu Val Ile 
    1400                 1405                 1410             


Ser Arg  Ile Thr His Ala Leu  Asp Leu Lys Glu His  Leu Gln Lys 
    1415                 1420                 1425             


Thr Val  Lys Lys Leu Pro Ala  Gly Ile Lys Arg Lys  Leu Cys Phe 
    1430                 1435                 1440             


Ala Leu  Ser Met Leu Gly Asn  Pro Gln Ile Thr Leu  Leu Asp Glu 
    1445                 1450                 1455             


Pro Ser  Thr Gly Met Asp Pro  Lys Ala Lys Gln His  Met Trp Arg 
    1460                 1465                 1470             


Ala Ile  Arg Thr Ala Phe Lys  Asn Arg Lys Arg Ala  Ala Ile Leu 
    1475                 1480                 1485             


Thr Thr  His Tyr Met Glu Glu  Ala Glu Ala Val Cys  Asp Arg Val 
    1490                 1495                 1500             


Ala Ile  Met Val Ser Gly Gln  Leu Arg Cys Ile Gly  Thr Val Gln 
    1505                 1510                 1515             


His Leu  Lys Ser Lys Phe Gly  Lys Gly Tyr Phe Leu  Glu Ile Lys 
    1520                 1525                 1530             


Leu Lys  Asp Trp Ile Glu Asn  Leu Glu Val Asp Arg  Leu Gln Arg 
    1535                 1540                 1545             


Glu Ile  Gln Tyr Ile Phe Pro  Asn Ala Ser Arg Gln  Glu Ser Phe 
    1550                 1555                 1560             


Ser Ser  Ile Leu Ala Tyr Lys  Ile Pro Lys Glu Asp  Val Gln Ser 
    1565                 1570                 1575             


Leu Ser  Gln Ser Phe Phe Lys  Leu Glu Glu Ala Lys  His Ala Phe 
    1580                 1585                 1590             


Ala Ile  Glu Glu Tyr Ser Phe  Ser Gln Ala Thr Leu  Glu Gln Val 
    1595                 1600                 1605             


Phe Val  Glu Leu Thr Lys Glu  Gln Glu Glu Glu Asp  Asn Ser Cys 
    1610                 1615                 1620             


Gly Thr  Leu Asn Ser Thr Leu  Trp Trp Glu Arg Thr  Gln Glu Asp 
    1625                 1630                 1635             


Arg Val  Val Phe 
    1640         


<210>  6300
<211>  745
<212>  PRT
<213>  Homo sapiens

<400>  6300

Met Arg Pro Asp Ser His Pro Tyr Gly Phe Pro Trp Glu Leu Val Ile 
1               5                   10                  15      


Arg Ala Ala Val Ala Gly Phe Phe Ala Val Leu Phe Leu Trp Arg Ser 
            20                  25                  30          


Phe Arg Ser Val Thr Ser Arg Leu Tyr Val Arg Arg Glu Lys Lys Phe 
        35                  40                  45              


Ala Val Ala Leu Ser Gly Leu Ile Glu Glu Lys Cys Lys Leu Leu Glu 
    50                  55                  60                  


Lys Phe Ser Leu Val Gln Lys Glu Tyr Glu Gly Tyr Glu Val Glu Ser 
65                  70                  75                  80  


Ser Leu Lys Asn Ala Ser Phe Glu Lys Glu Ala Thr Glu Ala Gln Ser 
                85                  90                  95      


Leu Glu Ala Thr Cys Glu Lys Leu Asn Arg Phe Asn Ser Glu Leu Val 
            100                 105                 110         


His Glu Ile Leu Cys Leu Glu Lys Glu Leu Lys Glu Glu Lys Ser Lys 
        115                 120                 125             


His Ser Glu Gln Asn Glu Leu Met Ala Asp Ile Ser Lys Arg Ile Gln 
    130                 135                 140                 


Ser Leu Glu Asp Glu Ser Lys Ser Leu Lys Ser Gln Val Ala Glu Ala 
145                 150                 155                 160 


Lys Met Thr Phe Lys Arg Phe Gln Ala Asn Glu Glu Arg Leu Glu Ile 
                165                 170                 175     


Glu Ile Gln Asp Ala Trp Lys Glu Asn Ser Glu Leu Gln Glu Ser Gln 
            180                 185                 190         


Lys Gln Leu Leu Gln Glu Ala Glu Val Trp Lys Glu Gln Val Ser Glu 
        195                 200                 205             


Leu Ile Lys Gln Lys Arg Thr Phe Glu Asp Ser Lys Val His Ala Glu 
    210                 215                 220                 


Gln Val Leu Asn Asp Lys Glu Asn His Ile Lys Thr Leu Thr Glu Arg 
225                 230                 235                 240 


Leu Leu Lys Met Lys Asp Gly Val Ala Met Leu Glu Glu Asp Val Thr 
                245                 250                 255     


Asp Asp Asp Asn Leu Glu Leu Glu Met Asn Ser Glu Ser Glu Asp Gly 
            260                 265                 270         


Ala Tyr Leu Asp Asn Pro Pro Lys Gly Ala Leu Lys Lys Leu Ile His 
        275                 280                 285             


Ala Ala Lys Leu Asn Ala Ser Leu Lys Thr Leu Glu Gly Glu Arg Asn 
    290                 295                 300                 


Gln Ile Tyr Ile Gln Leu Ser Glu Val Asp Lys Thr Lys Glu Glu Leu 
305                 310                 315                 320 


Thr Glu His Ile Lys Asn Leu Gln Thr Glu Gln Ala Ser Leu Gln Ser 
                325                 330                 335     


Glu Asn Thr His Phe Glu Ser Glu Asn Gln Lys Leu Gln Gln Lys Leu 
            340                 345                 350         


Lys Val Met Thr Glu Leu Tyr Gln Glu Asn Glu Met Lys Leu Tyr Arg 
        355                 360                 365             


Lys Leu Ile Val Glu Glu Lys Cys Arg Leu Glu Lys Glu Glu Lys Leu 
    370                 375                 380                 


Ser Lys Val Asp Glu Met Ile Ser His Ala Thr Glu Glu Leu Glu Thr 
385                 390                 395                 400 


Tyr Arg Lys Arg Ala Lys Asp Leu Lys Glu Phe Glu Lys Thr Ile His 
                405                 410                 415     


Phe Tyr Gln Lys Lys Ile Ile Leu His Glu Lys Lys Ala His Asp Asn 
            420                 425                 430         


Trp Ser Ala Ala Trp Thr Ala Glu Arg Asn Leu Asn Asp Leu Arg Lys 
        435                 440                 445             


Glu Asn Ala His Asn Arg Gln Lys Leu Thr Glu Ile Glu Phe Lys Ile 
    450                 455                 460                 


Lys Leu Leu Glu Lys Asp Pro Tyr Gly Leu Asp Val Pro Asn Thr Ala 
465                 470                 475                 480 


Phe Gly Arg Gln His Ser Pro Tyr Gly Pro Ser Pro Leu Gly Trp Pro 
                485                 490                 495     


Ser Ser Glu Thr Arg Ala Ser Leu Tyr Pro Pro Thr Leu Leu Glu Gly 
            500                 505                 510         


Pro Leu Arg Leu Ser Pro Leu Leu Pro Arg Gly Gly Gly Arg Gly Ser 
        515                 520                 525             


Arg Gly Pro Gly Asn Pro Pro Asp His Gln Ile Thr Lys Glu Arg Gly 
    530                 535                 540                 


Glu Ser Ser Cys Asp Arg Leu Thr Asp Pro His Arg Ala Pro Ser Asp 
545                 550                 555                 560 


Ala Gly Pro Leu Ala Pro Pro Trp Glu Gln Asp Tyr Arg Met Met Phe 
                565                 570                 575     


Pro Pro Pro Gly Gln Ser Tyr Pro Asp Ser Ala Leu Pro Pro Gln Arg 
            580                 585                 590         


Gln Asp Arg Phe Tyr Ser Asn Cys Ala Arg Leu Ser Gly Pro Ala Glu 
        595                 600                 605             


Leu Arg Ser Phe Asn Met Pro Ser Leu Asp Lys Met Asp Gly Ser Met 
    610                 615                 620                 


Pro Ser Glu Met Glu Ser Ser Arg Asn Asp Thr Lys Asp Asn Leu Gly 
625                 630                 635                 640 


Asn Leu Lys Val Pro Asp Ser Ser Leu Pro Ala Glu Asn Glu Ala Thr 
                645                 650                 655     


Gly Pro Gly Phe Val Pro Pro Pro Leu Ala Pro Ile Arg Gly Leu Leu 
            660                 665                 670         


Phe Pro Val Asp Thr Arg Gly Pro Phe Ile Arg Arg Gly Pro Pro Phe 
        675                 680                 685             


Pro Pro Pro Pro Pro Gly Thr Val Phe Gly Ala Ser Pro Asp Tyr Phe 
    690                 695                 700                 


Ser Pro Arg Asp Val Pro Gly Pro Pro Arg Ala Pro Phe Ala Met Arg 
705                 710                 715                 720 


Asn Val Tyr Leu Pro Arg Gly Phe Leu Pro Tyr Arg Pro Pro Arg Pro 
                725                 730                 735     


Ala Phe Phe Pro Pro Ala Pro Thr Phe 
            740                 745 


<210>  6301
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  6301

Met Met Pro Gln Glu Gln Tyr Thr His His Arg Ser Thr Met Pro Gly 
1               5                   10                  15      


Ser Val Gly Pro Gln Val Tyr Lys Val Gly Ile Tyr Gly Trp Arg Lys 
            20                  25                  30          


Arg Cys Leu Tyr Phe Phe Val Leu Leu Leu Met Ile Leu Ile Leu Val 
        35                  40                  45              


Asn Leu Ala Met Thr Ile Trp Ile Leu Lys Val Met Asn Phe Thr Ile 
    50                  55                  60                  


Asp Gly Met Gly Asn Leu Arg Ile Thr Glu Lys Gly Leu Lys Leu Glu 
65                  70                  75                  80  


Gly Asp Ser Glu Phe Leu Gln Pro Leu Tyr Ala Lys Glu Ile Gln Ser 
                85                  90                  95      


Arg Pro Gly Asn Ala Leu Tyr Phe Lys Ser Ala Arg Asn Val Thr Val 
            100                 105                 110         


Asn Ile Leu Asn Asp Gln Thr Lys Val Leu Thr Gln Leu Ile Thr Gly 
        115                 120                 125             


Pro Lys Ala Val Glu Ala Tyr Gly Lys Lys Phe Glu Val Lys Thr Val 
    130                 135                 140                 


Ser Gly Lys Leu Leu Phe Ser Ala Asp Asn Asn Glu Val Val Val Gly 
145                 150                 155                 160 


Ala Glu Arg Leu Arg Val Leu Gly Ala Glu Gly Thr Val Phe Pro Lys 
                165                 170                 175     


Ser Ile Glu Thr Pro Asn Val Arg Ala Asp Pro Phe Lys Glu Leu Arg 
            180                 185                 190         


Leu Glu Ser Pro Thr Arg Ser Leu Val Met Glu Ala Pro Lys Gly Val 
        195                 200                 205             


Glu Ile Asn Ala Glu Ala Gly Asn Met Glu Ala Thr Cys Arg Thr Glu 
    210                 215                 220                 


Leu Arg Leu Glu Ser Lys Asp Gly Glu Val Arg Asp Glu Lys Asp Arg 
225                 230                 235                 240 


Ser Ser Lys Ser Tyr Ser Phe Asn Arg Pro Thr Leu Pro Ile Thr Gly 
                245                 250                 255     


<210>  6302
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  6302

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser 
65                  70                  75                  80  


Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val 
                85                  90                  95      


His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro 
            100                 105                 110         


Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile 
        115                 120                 125             


Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala 
    130                 135                 140                 


Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg 
145                 150                 155                 160 


Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val 
                165                 170                 175     


Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe 
            180                 185                 190         


Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser 
        195                 200                 205             


Leu Leu Asp Thr Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val 
    210                 215                 220                 


Thr Val Arg Cys Asn Thr Thr His Cys Leu Val Arg Trp Lys Gln Pro 
225                 230                 235                 240 


Arg Thr Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp 
                245                 250                 255     


Val His Arg Lys Asn Thr Gln Pro Gly Thr Glu Asn Leu Leu Ile Asn 
            260                 265                 270         


Val Ser Gly Asp Leu Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro 
        275                 280                 285             


Arg Ala Lys His Ser Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu 
    290                 295                 300                 


Asn Trp Ser Ser Trp Ser Glu Ala Ile Glu Phe Gly Ser Asp Asp Gly 
305                 310                 315                 320 


Asn Leu Gly Ser Val Tyr Ile Tyr Val Leu Leu Ile Val Gly Thr Leu 
                325                 330                 335     


Val Cys Gly Ile Val Leu Gly Phe Leu Phe Lys Arg Phe Leu Arg Ile 
            340                 345                 350         


Gln Arg Leu Phe Pro Pro Val Pro Gln Ile Lys Asp Lys Leu Asn Asp 
        355                 360                 365             


Asn His Glu Val Glu Asp Glu Ile Ile Trp Glu Glu Phe Thr Pro Glu 
    370                 375                 380                 


Glu Gly Lys Gly Tyr Arg Glu Glu Val Leu Thr Val Lys Glu Ile Thr 
385                 390                 395                 400 


<210>  6303
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  6303

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser 
65                  70                  75                  80  


Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val 
                85                  90                  95      


His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro 
            100                 105                 110         


Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile 
        115                 120                 125             


Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala 
    130                 135                 140                 


Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg 
145                 150                 155                 160 


Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val 
                165                 170                 175     


Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe 
            180                 185                 190         


Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser 
        195                 200                 205             


Leu Leu Asp Thr Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val 
    210                 215                 220                 


Thr Val Arg Cys Asn Thr Thr His Cys Leu Val Arg Trp Lys Gln Pro 
225                 230                 235                 240 


Arg Thr Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp 
                245                 250                 255     


Val His Arg Lys Asn Thr Gln Pro Gly Thr Glu Asn Leu Leu Ile Asn 
            260                 265                 270         


Val Ser Gly Asp Leu Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro 
        275                 280                 285             


Arg Ala Lys His Ser Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu 
    290                 295                 300                 


Asn Trp Ser Ser Trp Ser Glu Ala Ile Glu Phe Asp His Leu Gly Gly 
305                 310                 315                 320 


Ile His Pro Arg Gly Arg Glu Arg Leu Pro Arg Arg Gly Leu Asp Arg 
                325                 330                 335     


Glu Gly Asn Tyr Leu Arg Pro Arg Gly Cys Arg Asn Gly Met Asp Ile 
            340                 345                 350         


Ser Ala Ser Ala Thr Arg Gly Asn Cys Phe Leu Asp Asp Ala Val Asn 
        355                 360                 365             


Leu Tyr Ile Ile Phe Tyr Val Phe Ile 
    370                 375         


<210>  6304
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  6304

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser 
65                  70                  75                  80  


Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val 
                85                  90                  95      


His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro 
            100                 105                 110         


Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile 
        115                 120                 125             


Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala 
    130                 135                 140                 


Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg 
145                 150                 155                 160 


Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val 
                165                 170                 175     


Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe 
            180                 185                 190         


Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser 
        195                 200                 205             


Leu Leu Asp Thr Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val 
    210                 215                 220                 


Thr Val Arg Cys Asn Thr Thr His Cys Leu Val Arg Trp Lys Gln Pro 
225                 230                 235                 240 


Arg Thr Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp 
                245                 250                 255     


Val His Arg Lys Asn Thr Gln Pro Gly Thr Glu Asn Leu Leu Ile Asn 
            260                 265                 270         


Val Ser Gly Asp Leu Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro 
        275                 280                 285             


Arg Ala Lys His Ser Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu 
    290                 295                 300                 


Asn Trp Ser Ser Trp Ser Glu Ala Ile Glu Phe Gly Ser Leu Gly Tyr 
305                 310                 315                 320 


Ser Gly Cys Ser Arg Gln Phe His Arg Ser Lys Thr Asn 
                325                 330             


<210>  6305
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  6305

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser 
65                  70                  75                  80  


Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val 
                85                  90                  95      


His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro 
            100                 105                 110         


Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile 
        115                 120                 125             


Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala 
    130                 135                 140                 


Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg 
145                 150                 155                 160 


Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val 
                165                 170                 175     


Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe 
            180                 185                 190         


Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser 
        195                 200                 205             


Leu Leu Asp Thr Lys Lys Ile Gly Ser Leu Gly Tyr Ser Gly Cys Ser 
    210                 215                 220                 


Arg Gln Phe His Arg Ser Lys Thr Asn 
225                 230             


<210>  6306
<211>  783
<212>  PRT
<213>  Homo sapiens

<400>  6306

Met Ala Arg Leu Gly Asn Cys Ser Leu Thr Trp Ala Ala Leu Ile Ile 
1               5                   10                  15      


Leu Leu Leu Pro Gly Ser Leu Glu Glu Cys Gly His Ile Ser Val Ser 
            20                  25                  30          


Ala Pro Ile Val His Leu Gly Asp Pro Ile Thr Ala Ser Cys Ile Ile 
        35                  40                  45              


Lys Gln Asn Cys Ser His Leu Asp Pro Glu Pro Gln Ile Leu Trp Arg 
    50                  55                  60                  


Leu Gly Ala Glu Leu Gln Pro Gly Gly Arg Gln Gln Arg Leu Ser Asp 
65                  70                  75                  80  


Gly Thr Gln Glu Ser Ile Ile Thr Leu Pro His Leu Asn His Thr Gln 
                85                  90                  95      


Ala Phe Leu Ser Cys Cys Leu Asn Trp Gly Asn Ser Leu Gln Ile Leu 
            100                 105                 110         


Asp Gln Val Glu Leu Arg Ala Gly Tyr Pro Pro Ala Ile Pro His Asn 
        115                 120                 125             


Leu Ser Cys Leu Met Asn Leu Thr Thr Ser Ser Leu Ile Cys Gln Trp 
    130                 135                 140                 


Glu Pro Gly Pro Glu Thr His Leu Pro Thr Ser Phe Thr Leu Lys Ser 
145                 150                 155                 160 


Phe Lys Ser Arg Gly Asn Cys Gln Thr Gln Gly Asp Ser Ile Leu Asp 
                165                 170                 175     


Cys Val Pro Lys Asp Gly Gln Ser His Cys Cys Ile Pro Arg Lys His 
            180                 185                 190         


Leu Leu Leu Tyr Gln Asn Met Gly Ile Trp Val Gln Ala Glu Asn Ala 
        195                 200                 205             


Leu Gly Thr Ser Met Ser Pro Gln Leu Cys Leu Asp Pro Met Asp Val 
    210                 215                 220                 


Val Lys Leu Glu Pro Pro Met Leu Arg Thr Met Asp Pro Ser Pro Glu 
225                 230                 235                 240 


Ala Ala Pro Pro Gln Ala Gly Cys Leu Gln Leu Cys Trp Glu Pro Trp 
                245                 250                 255     


Gln Pro Gly Leu His Ile Asn Gln Lys Cys Glu Leu Arg His Lys Pro 
            260                 265                 270         


Gln Arg Gly Glu Ala Ser Trp Ala Leu Val Gly Pro Leu Pro Leu Glu 
        275                 280                 285             


Ala Leu Gln Tyr Glu Leu Cys Gly Leu Leu Pro Ala Thr Ala Tyr Thr 
    290                 295                 300                 


Leu Gln Ile Arg Cys Ile Arg Trp Pro Leu Pro Gly His Trp Ser Asp 
305                 310                 315                 320 


Trp Ser Pro Ser Leu Glu Leu Arg Thr Thr Glu Arg Ala Pro Thr Val 
                325                 330                 335     


Arg Leu Asp Thr Trp Trp Arg Gln Arg Gln Leu Asp Pro Arg Thr Val 
            340                 345                 350         


Gln Leu Phe Trp Lys Pro Val Pro Leu Glu Glu Asp Ser Gly Arg Ile 
        355                 360                 365             


Gln Gly Tyr Val Val Ser Trp Arg Pro Ser Gly Gln Ala Gly Ala Ile 
    370                 375                 380                 


Leu Pro Leu Cys Asn Thr Thr Glu Leu Ser Cys Thr Phe His Leu Pro 
385                 390                 395                 400 


Ser Glu Ala Gln Glu Val Ala Leu Val Ala Tyr Asn Ser Ala Gly Thr 
                405                 410                 415     


Ser Arg Pro Thr Pro Val Val Phe Ser Glu Ser Arg Gly Pro Ala Leu 
            420                 425                 430         


Thr Arg Leu His Ala Met Ala Arg Asp Pro His Ser Leu Trp Val Gly 
        435                 440                 445             


Trp Glu Pro Pro Asn Pro Trp Pro Gln Gly Tyr Val Ile Glu Trp Gly 
    450                 455                 460                 


Leu Gly Pro Pro Ser Ala Ser Asn Ser Asn Lys Thr Trp Arg Met Glu 
465                 470                 475                 480 


Gln Asn Gly Arg Ala Thr Gly Phe Leu Leu Lys Glu Asn Ile Arg Pro 
                485                 490                 495     


Phe Gln Leu Tyr Glu Ile Ile Val Thr Pro Leu Tyr Gln Asp Thr Met 
            500                 505                 510         


Gly Pro Ser Gln His Val Tyr Ala Tyr Ser Gln Glu Met Ala Pro Ser 
        515                 520                 525             


His Ala Pro Glu Leu His Leu Lys His Ile Gly Lys Thr Trp Ala Gln 
    530                 535                 540                 


Leu Glu Trp Val Pro Glu Pro Pro Glu Leu Gly Lys Ser Pro Leu Thr 
545                 550                 555                 560 


His Tyr Thr Ile Phe Trp Thr Asn Ala Gln Asn Gln Ser Phe Ser Ala 
                565                 570                 575     


Ile Leu Asn Ala Ser Ser Arg Gly Phe Val Leu His Gly Leu Glu Pro 
            580                 585                 590         


Ala Ser Leu Tyr His Ile His Leu Met Ala Ala Ser Gln Ala Gly Ala 
        595                 600                 605             


Thr Asn Ser Thr Val Leu Thr Leu Met Thr Leu Thr Pro Glu Gly Ser 
    610                 615                 620                 


Glu Leu His Ile Ile Leu Gly Leu Phe Gly Leu Leu Leu Leu Leu Thr 
625                 630                 635                 640 


Cys Leu Cys Gly Thr Ala Trp Leu Cys Cys Ser Pro Asn Arg Lys Asn 
                645                 650                 655     


Pro Leu Trp Pro Ser Val Pro Asp Pro Ala His Ser Ser Leu Gly Ser 
            660                 665                 670         


Trp Val Pro Thr Ile Met Glu Glu Asp Ala Phe Gln Leu Pro Gly Leu 
        675                 680                 685             


Gly Thr Pro Pro Ile Thr Lys Leu Thr Val Leu Glu Glu Asp Glu Lys 
    690                 695                 700                 


Lys Pro Val Pro Trp Glu Ser His Asn Ser Ser Glu Thr Cys Gly Leu 
705                 710                 715                 720 


Pro Thr Leu Val Gln Thr Tyr Val Leu Gln Gly Asp Pro Arg Ala Val 
                725                 730                 735     


Ser Thr Gln Pro Gln Ser Gln Ser Gly Thr Ser Asp Gln Ala Gly Pro 
            740                 745                 750         


Pro Arg Arg Ser Ala Tyr Phe Lys Asp Gln Ile Met Leu His Pro Ala 
        755                 760                 765             


Pro Pro Asn Gly Leu Leu Cys Leu Phe Pro Ile Thr Ser Val Leu 
    770                 775                 780             


<210>  6307
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  6307

Met Tyr Gln Val Val Ala Phe Leu Ala Met Val Met Gly Thr His Thr 
1               5                   10                  15      


Tyr Ser His Trp Pro Ser Cys Cys Pro Ser Lys Gly Gln Asp Thr Ser 
            20                  25                  30          


Glu Glu Leu Leu Arg Trp Ser Thr Val Pro Val Pro Pro Leu Glu Pro 
        35                  40                  45              


Ala Arg Pro Asn Arg His Pro Glu Ser Cys Arg Ala Ser Glu Asp Gly 
    50                  55                  60                  


Pro Leu Asn Ser Arg Ala Ile Ser Pro Trp Arg Tyr Glu Leu Asp Arg 
65                  70                  75                  80  


Asp Leu Asn Arg Leu Pro Gln Asp Leu Tyr His Ala Arg Cys Leu Cys 
                85                  90                  95      


Pro His Cys Val Ser Leu Gln Thr Gly Ser His Met Asp Pro Arg Gly 
            100                 105                 110         


Asn Ser Glu Leu Leu Tyr His Asn Gln Thr Val Phe Tyr Arg Arg Pro 
        115                 120                 125             


Cys His Gly Glu Lys Gly Thr His Lys Gly Tyr Cys Leu Glu Arg Arg 
    130                 135                 140                 


Leu Tyr Arg Val Ser Leu Ala Cys Val Cys Val Arg Pro Arg Val Met 
145                 150                 155                 160 


Gly 
    


<210>  6308
<211>  425
<212>  PRT
<213>  Homo sapiens

<400>  6308

Met Thr Phe Gly Arg Ser Gly Ala Ala Ser Val Val Leu Asn Val Gly 
1               5                   10                  15      


Gly Ala Arg Tyr Ser Leu Ser Arg Glu Leu Leu Lys Asp Phe Pro Leu 
            20                  25                  30          


Arg Arg Val Ser Arg Leu His Gly Cys Arg Ser Glu Arg Asp Val Leu 
        35                  40                  45              


Glu Val Cys Asp Asp Tyr Asp Arg Glu Arg Asn Glu Tyr Phe Phe Asp 
    50                  55                  60                  


Arg His Ser Glu Ala Phe Gly Phe Ile Leu Leu Tyr Val Arg Gly His 
65                  70                  75                  80  


Gly Lys Leu Arg Phe Ala Pro Arg Met Cys Glu Leu Ser Phe Tyr Asn 
                85                  90                  95      


Glu Met Ile Tyr Trp Gly Leu Glu Gly Ala His Leu Glu Tyr Cys Cys 
            100                 105                 110         


Gln Arg Arg Leu Asp Asp Arg Met Ser Asp Thr Tyr Thr Phe Tyr Ser 
        115                 120                 125             


Ala Asp Glu Pro Gly Val Leu Gly Arg Asp Glu Ala Arg Pro Gly Gly 
    130                 135                 140                 


Ala Glu Ala Ala Pro Ser Arg Arg Trp Leu Glu Arg Met Arg Arg Thr 
145                 150                 155                 160 


Phe Glu Glu Pro Thr Ser Ser Leu Ala Ala Gln Ile Leu Ala Ser Val 
                165                 170                 175     


Ser Val Val Phe Val Ile Val Ser Met Val Val Leu Cys Ala Ser Thr 
            180                 185                 190         


Leu Pro Asp Trp Arg Asn Ala Ala Ala Asp Asn Arg Ser Leu Asp Asp 
        195                 200                 205             


Arg Ser Arg Ile Ile Glu Ala Ile Cys Ile Gly Trp Phe Thr Ala Glu 
    210                 215                 220                 


Cys Ile Val Arg Phe Ile Val Ser Lys Asn Lys Cys Glu Phe Val Lys 
225                 230                 235                 240 


Arg Pro Leu Asn Ile Ile Asp Leu Leu Ala Ile Thr Pro Tyr Tyr Ile 
                245                 250                 255     


Ser Val Leu Met Thr Val Phe Thr Gly Glu Asn Ser Gln Leu Gln Arg 
            260                 265                 270         


Ala Gly Val Thr Leu Arg Val Leu Arg Met Met Arg Ile Phe Trp Val 
        275                 280                 285             


Ile Lys Leu Ala Arg His Phe Ile Gly Leu Gln Thr Leu Gly Leu Thr 
    290                 295                 300                 


Leu Lys Arg Cys Tyr Arg Glu Met Val Met Leu Leu Val Phe Ile Cys 
305                 310                 315                 320 


Val Ala Met Ala Ile Phe Ser Ala Leu Ser Gln Leu Leu Glu His Gly 
                325                 330                 335     


Leu Asp Leu Glu Thr Ser Asn Lys Asp Phe Thr Ser Ile Pro Ala Ala 
            340                 345                 350         


Cys Trp Trp Val Ile Ile Ser Met Thr Thr Val Gly Tyr Gly Asp Met 
        355                 360                 365             


Tyr Pro Ile Thr Val Pro Gly Arg Ile Leu Gly Gly Val Cys Val Val 
    370                 375                 380                 


Ser Gly Ile Val Leu Leu Ala Leu Pro Ile Thr Phe Ile Tyr His Ser 
385                 390                 395                 400 


Phe Val Gln Cys Tyr His Glu Leu Lys Phe Arg Ser Ala Arg Tyr Ser 
                405                 410                 415     


Arg Ser Leu Ser Thr Glu Phe Leu Asn 
            420                 425 


<210>  6309
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  6309

Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Asp Ala Cys Glu Glu Pro Pro Thr Phe Glu Ala Met Glu Leu Ile Gly 
        35                  40                  45              


Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys 
    50                  55                  60                  


Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Thr His Thr Ile Cys 
65                  70                  75                  80  


Asp Arg Asn His Thr Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg 
                85                  90                  95      


Glu Thr Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
            100                 105                 110         


Ala Asn Gly Thr Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
        115                 120                 125             


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
    130                 135                 140                 


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
145                 150                 155                 160 


Leu Cys Thr Pro Pro Pro Lys Ile Lys Asn Gly Lys His Thr Phe Ser 
                165                 170                 175     


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Thr Tyr Ser Cys Asp 
            180                 185                 190         


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Thr Ile 
        195                 200                 205             


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
    210                 215                 220                 


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
225                 230                 235                 240 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Thr Val Met Phe Glu Cys 
                245                 250                 255     


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Thr Ile Val Cys Asp Ser 
            260                 265                 270         


Asn Ser Thr Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Gly Pro Arg 
        275                 280                 285             


Pro Thr Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro 
    290                 295                 300                 


Glu Glu Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val Ile 
305                 310                 315                 320 


Val Ile Ala Ile Gly Lys Gln Met Val Glu Leu Asn Met Pro Leu Thr 
                325                 330                 335     


Arg Leu Asn Gln Pro Leu Gln Gln Ser Arg Glu Ala Glu 
            340                 345                 


<210>  6310
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  6310

Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Asp Ala Cys Glu Glu Pro Pro Thr Phe Glu Ala Met Glu Leu Ile Gly 
        35                  40                  45              


Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys 
    50                  55                  60                  


Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Thr His Thr Ile Cys 
65                  70                  75                  80  


Asp Arg Asn His Thr Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg 
                85                  90                  95      


Glu Thr Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
            100                 105                 110         


Ala Asn Gly Thr Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
        115                 120                 125             


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
    130                 135                 140                 


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
145                 150                 155                 160 


Leu Cys Thr Pro Pro Pro Lys Ile Lys Asn Gly Lys His Thr Phe Ser 
                165                 170                 175     


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Thr Tyr Ser Cys Asp 
            180                 185                 190         


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Thr Ile 
        195                 200                 205             


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
    210                 215                 220                 


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
225                 230                 235                 240 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Thr Val Met Phe Glu Cys 
                245                 250                 255     


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Thr Ile Val Cys Asp Ser 
            260                 265                 270         


Asn Ser Thr Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Val Ser Thr 
        275                 280                 285             


Ser Ser Thr Thr Lys Ser Pro Ala Ser Ser Ala Ser Gly Pro Arg Pro 
    290                 295                 300                 


Thr Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro Glu 
305                 310                 315                 320 


Glu Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val Ile Val 
                325                 330                 335     


Ile Ala Ile Val Val Gly Val Ala Val Ile Cys Val Val Pro Tyr Arg 
            340                 345                 350         


Tyr Leu Gln Arg Arg Lys Lys Lys Gly Thr Tyr Leu Thr Asp Glu Thr 
        355                 360                 365             


His Arg Glu Val Lys Phe Thr Ser Leu 
    370                 375         


<210>  6311
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  6311

Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Asp Ala Cys Glu Glu Pro Pro Thr Phe Glu Ala Met Glu Leu Ile Gly 
        35                  40                  45              


Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys 
    50                  55                  60                  


Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Thr His Thr Ile Cys 
65                  70                  75                  80  


Asp Arg Asn His Thr Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg 
                85                  90                  95      


Glu Thr Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
            100                 105                 110         


Ala Asn Gly Thr Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
        115                 120                 125             


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
    130                 135                 140                 


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
145                 150                 155                 160 


Leu Cys Thr Pro Pro Pro Lys Ile Lys Asn Gly Lys His Thr Phe Ser 
                165                 170                 175     


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Thr Tyr Ser Cys Asp 
            180                 185                 190         


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Thr Ile 
        195                 200                 205             


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
    210                 215                 220                 


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
225                 230                 235                 240 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Thr Val Met Phe Glu Cys 
                245                 250                 255     


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Thr Ile Val Cys Asp Ser 
            260                 265                 270         


Asn Ser Thr Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Gly Pro Arg 
        275                 280                 285             


Pro Thr Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro 
    290                 295                 300                 


Glu Glu Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val Ile 
305                 310                 315                 320 


Val Ile Ala Ile Val Val Gly Val Ala Val Ile Cys Val Val Pro Tyr 
                325                 330                 335     


Arg Tyr Leu Gln Arg Arg Lys Lys Lys Gly Thr Tyr Leu Thr Asp Glu 
            340                 345                 350         


Thr His Arg Glu Val Lys Phe Thr Ser Leu 
        355                 360         


<210>  6312
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  6312

Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Asp Ala Cys Glu Glu Pro Pro Thr Phe Glu Ala Met Glu Leu Ile Gly 
        35                  40                  45              


Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys 
    50                  55                  60                  


Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Thr His Thr Ile Cys 
65                  70                  75                  80  


Asp Arg Asn His Thr Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg 
                85                  90                  95      


Glu Thr Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
            100                 105                 110         


Ala Asn Gly Thr Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
        115                 120                 125             


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
    130                 135                 140                 


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
145                 150                 155                 160 


Leu Cys Thr Pro Pro Pro Lys Ile Lys Asn Gly Lys His Thr Phe Ser 
                165                 170                 175     


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Thr Tyr Ser Cys Asp 
            180                 185                 190         


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Thr Ile 
        195                 200                 205             


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
    210                 215                 220                 


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
225                 230                 235                 240 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Thr Val Met Phe Glu Cys 
                245                 250                 255     


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Thr Ile Val Cys Asp Ser 
            260                 265                 270         


Asn Ser Thr Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Gly Pro Arg 
        275                 280                 285             


Pro Thr Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro 
    290                 295                 300                 


Glu Glu Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val Ile 
305                 310                 315                 320 


Val Ile Ala Ile Val Val Gly Val Ala Val Ile Cys Val Val Pro Tyr 
                325                 330                 335     


Arg Tyr Leu Gln Arg Arg Lys Lys Lys Gly Lys Ala Asp Gly Gly Ala 
            340                 345                 350         


Glu Tyr Ala Thr Tyr Gln Thr Lys Ser Thr Thr Pro Ala Glu Gln Arg 
        355                 360                 365             


Gly 
    


<210>  6313
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  6313

Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Asp Ala Cys Glu Glu Pro Pro Thr Phe Glu Ala Met Glu Leu Ile Gly 
        35                  40                  45              


Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys 
    50                  55                  60                  


Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Thr His Thr Ile Cys 
65                  70                  75                  80  


Asp Arg Asn His Thr Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg 
                85                  90                  95      


Glu Thr Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
            100                 105                 110         


Ala Asn Gly Thr Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
        115                 120                 125             


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
    130                 135                 140                 


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
145                 150                 155                 160 


Leu Cys Thr Pro Pro Pro Lys Ile Lys Asn Gly Lys His Thr Phe Ser 
                165                 170                 175     


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Thr Tyr Ser Cys Asp 
            180                 185                 190         


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Thr Ile 
        195                 200                 205             


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
    210                 215                 220                 


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
225                 230                 235                 240 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Thr Val Met Phe Glu Cys 
                245                 250                 255     


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Thr Ile Val Cys Asp Ser 
            260                 265                 270         


Asn Ser Thr Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Gly Pro Arg 
        275                 280                 285             


Pro Thr Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro 
    290                 295                 300                 


Glu Glu Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val Ile 
305                 310                 315                 320 


Val Ile Ala Ile Val Val Gly Val Ala Val Ile Cys Val Val Pro Tyr 
                325                 330                 335     


Arg Tyr Leu Gln Arg Arg Lys Lys Lys Gly Lys Ala Asp Gly Gly Ala 
            340                 345                 350         


Glu Tyr Ala Thr Tyr Gln Thr Lys Ser Thr Thr Pro Ala Glu Gln Arg 
        355                 360                 365             


Gly 
    


<210>  6314
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  6314

Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Asp Ala Cys Glu Glu Pro Pro Thr Phe Glu Ala Met Glu Leu Ile Gly 
        35                  40                  45              


Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys 
    50                  55                  60                  


Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Thr His Thr Ile Cys 
65                  70                  75                  80  


Asp Arg Asn His Thr Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg 
                85                  90                  95      


Glu Thr Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
            100                 105                 110         


Ala Asn Gly Thr Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
        115                 120                 125             


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
    130                 135                 140                 


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
145                 150                 155                 160 


Leu Cys Thr Pro Pro Pro Lys Ile Lys Asn Gly Lys His Thr Phe Ser 
                165                 170                 175     


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Thr Tyr Ser Cys Asp 
            180                 185                 190         


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Thr Ile 
        195                 200                 205             


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
    210                 215                 220                 


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
225                 230                 235                 240 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Thr Val Met Phe Glu Cys 
                245                 250                 255     


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Thr Ile Val Cys Asp Ser 
            260                 265                 270         


Asn Ser Thr Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Gly Pro Arg 
        275                 280                 285             


Pro Thr Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro 
    290                 295                 300                 


Glu Glu Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val Ile 
305                 310                 315                 320 


Val Ile Ala Ile Val Val Gly Val Ala Val Ile Cys Val Val Pro Tyr 
                325                 330                 335     


Arg Tyr Leu Gln Arg Arg Lys Lys Lys Gly Lys Ala Asp Gly Gly Ala 
            340                 345                 350         


Glu Tyr Ala Thr Tyr Gln Thr Lys Ser Thr Thr Pro Ala Glu Gln Arg 
        355                 360                 365             


Gly 
    


<210>  6315
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  6315

Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Asp Ala Cys Glu Glu Pro Pro Thr Phe Glu Ala Met Glu Leu Ile Gly 
        35                  40                  45              


Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys 
    50                  55                  60                  


Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Thr His Thr Ile Cys 
65                  70                  75                  80  


Asp Arg Asn His Thr Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg 
                85                  90                  95      


Glu Thr Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
            100                 105                 110         


Ala Asn Gly Thr Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
        115                 120                 125             


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
    130                 135                 140                 


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
145                 150                 155                 160 


Leu Cys Thr Pro Pro Pro Lys Ile Lys Asn Gly Lys His Thr Phe Ser 
                165                 170                 175     


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Thr Tyr Ser Cys Asp 
            180                 185                 190         


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Thr Ile 
        195                 200                 205             


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
    210                 215                 220                 


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
225                 230                 235                 240 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Thr Val Met Phe Glu Cys 
                245                 250                 255     


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Thr Ile Val Cys Asp Ser 
            260                 265                 270         


Asn Ser Thr Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Gly Pro Arg 
        275                 280                 285             


Pro Thr Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro 
    290                 295                 300                 


Glu Glu Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val Ile 
305                 310                 315                 320 


Val Ile Ala Ile Val Val Gly Val Ala Val Ile Cys Val Val Pro Tyr 
                325                 330                 335     


Arg Tyr Leu Gln Arg Arg Lys Lys Lys Gly Lys Ala Asp Gly Gly Ala 
            340                 345                 350         


Glu Tyr Ala Thr Tyr Gln Thr Lys Ser Thr Thr Pro Ala Glu Gln Arg 
        355                 360                 365             


Gly 
    


<210>  6316
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  6316

Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Asp Ala Cys Glu Glu Pro Pro Thr Phe Glu Ala Met Glu Leu Ile Gly 
        35                  40                  45              


Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys 
    50                  55                  60                  


Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Thr His Thr Ile Cys 
65                  70                  75                  80  


Asp Arg Asn His Thr Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg 
                85                  90                  95      


Glu Thr Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
            100                 105                 110         


Ala Asn Gly Thr Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
        115                 120                 125             


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
    130                 135                 140                 


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
145                 150                 155                 160 


Leu Cys Thr Pro Pro Pro Lys Ile Lys Asn Gly Lys His Thr Phe Ser 
                165                 170                 175     


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Thr Tyr Ser Cys Asp 
            180                 185                 190         


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Thr Ile 
        195                 200                 205             


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
    210                 215                 220                 


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
225                 230                 235                 240 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Thr Val Met Phe Glu Cys 
                245                 250                 255     


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Thr Ile Val Cys Asp Ser 
            260                 265                 270         


Asn Ser Thr Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Gly Pro Arg 
        275                 280                 285             


Pro Thr Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro 
    290                 295                 300                 


Glu Glu Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val Ile 
305                 310                 315                 320 


Val Ile Ala Ile Val Val Gly Val Ala Val Ile Cys Val Val Pro Tyr 
                325                 330                 335     


Arg Tyr Leu Gln Arg Arg Lys Lys Lys Gly Lys Ala Asp Gly Gly Ala 
            340                 345                 350         


Glu Tyr Ala Thr Tyr Gln Thr Lys Ser Thr Thr Pro Ala Glu Gln Arg 
        355                 360                 365             


Gly 
    


<210>  6317
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  6317

Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Asp Ala Cys Glu Glu Pro Pro Thr Phe Glu Ala Met Glu Leu Ile Gly 
        35                  40                  45              


Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys 
    50                  55                  60                  


Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Thr His Thr Ile Cys 
65                  70                  75                  80  


Asp Arg Asn His Thr Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg 
                85                  90                  95      


Glu Thr Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
            100                 105                 110         


Ala Asn Gly Thr Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
        115                 120                 125             


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
    130                 135                 140                 


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
145                 150                 155                 160 


Leu Cys Thr Pro Pro Pro Lys Ile Lys Asn Gly Lys His Thr Phe Ser 
                165                 170                 175     


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Thr Tyr Ser Cys Asp 
            180                 185                 190         


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Thr Ile 
        195                 200                 205             


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
    210                 215                 220                 


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
225                 230                 235                 240 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Thr Val Met Phe Glu Cys 
                245                 250                 255     


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Thr Ile Val Cys Asp Ser 
            260                 265                 270         


Asn Ser Thr Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Gly Pro Arg 
        275                 280                 285             


Pro Thr Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro 
    290                 295                 300                 


Glu Glu Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val Ile 
305                 310                 315                 320 


Val Ile Ala Ile Val Val Gly Val Ala Val Ile Cys Val Val Pro Tyr 
                325                 330                 335     


Arg Tyr Leu Gln Arg Arg Lys Lys Lys Gly Lys Ala Asp Gly Gly Ala 
            340                 345                 350         


Glu Tyr Ala Thr Tyr Gln Thr Lys Ser Thr Thr Pro Ala Glu Gln Arg 
        355                 360                 365             


Gly 
    


<210>  6318
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  6318

Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Asp Ala Cys Glu Glu Pro Pro Thr Phe Glu Ala Met Glu Leu Ile Gly 
        35                  40                  45              


Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys 
    50                  55                  60                  


Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Thr His Thr Ile Cys 
65                  70                  75                  80  


Asp Arg Asn His Thr Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg 
                85                  90                  95      


Glu Thr Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
            100                 105                 110         


Ala Asn Gly Thr Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
        115                 120                 125             


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
    130                 135                 140                 


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
145                 150                 155                 160 


Leu Cys Thr Pro Pro Pro Lys Ile Lys Asn Gly Lys His Thr Phe Ser 
                165                 170                 175     


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Thr Tyr Ser Cys Asp 
            180                 185                 190         


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Thr Ile 
        195                 200                 205             


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
    210                 215                 220                 


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
225                 230                 235                 240 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Thr Val Met Phe Glu Cys 
                245                 250                 255     


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Thr Ile Val Cys Asp Ser 
            260                 265                 270         


Asn Ser Thr Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Val Leu Pro 
        275                 280                 285             


Pro Ser Ser Thr Lys Pro Pro Ala Leu Ser His Ser Val Ser Thr Ser 
    290                 295                 300                 


Ser Thr Thr Lys Ser Pro Ala Ser Ser Ala Ser Gly Pro Arg Pro Thr 
305                 310                 315                 320 


Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro Glu Glu 
                325                 330                 335     


Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val Ile Val Ile 
            340                 345                 350         


Ala Ile Val Val Gly Val Ala Val Ile Cys Val Val Pro Tyr Arg Tyr 
        355                 360                 365             


Leu Gln Arg Arg Lys Lys Lys Gly Lys Ala Asp Gly Gly Ala Glu Tyr 
    370                 375                 380                 


Ala Thr Tyr Gln Thr Lys Ser Thr Thr Pro Ala Glu Gln Arg Gly 
385                 390                 395                 


<210>  6319
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  6319

Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Asp Ala Cys Glu Glu Pro Pro Thr Phe Glu Ala Met Glu Leu Ile Gly 
        35                  40                  45              


Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys 
    50                  55                  60                  


Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Thr His Thr Ile Cys 
65                  70                  75                  80  


Asp Arg Asn His Thr Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg 
                85                  90                  95      


Glu Thr Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
            100                 105                 110         


Ala Asn Gly Thr Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
        115                 120                 125             


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
    130                 135                 140                 


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
145                 150                 155                 160 


Leu Cys Thr Pro Pro Pro Lys Ile Lys Asn Gly Lys His Thr Phe Ser 
                165                 170                 175     


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Thr Tyr Ser Cys Asp 
            180                 185                 190         


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Thr Ile 
        195                 200                 205             


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
    210                 215                 220                 


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
225                 230                 235                 240 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Thr Val Met Phe Glu Cys 
                245                 250                 255     


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Thr Ile Val Cys Asp Ser 
            260                 265                 270         


Asn Ser Thr Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Gly Tyr Pro 
        275                 280                 285             


Lys Pro Glu Glu Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala 
    290                 295                 300                 


Val Ile Val Ile Ala Ile Val Val Gly Val Ala Val Ile Cys Val Val 
305                 310                 315                 320 


Pro Tyr Arg Tyr Leu Gln Arg Arg Lys Lys Lys Gly Lys Ala Asp Gly 
                325                 330                 335     


Gly Ala Glu Tyr Ala Thr Tyr Gln Thr Lys Ser Thr Thr Pro Ala Glu 
            340                 345                 350         


Gln Arg Gly 
        355 


<210>  6320
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  6320

Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Asp Ala Cys Glu Glu Pro Pro Thr Phe Glu Ala Met Glu Leu Ile Gly 
        35                  40                  45              


Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys 
    50                  55                  60                  


Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Thr His Thr Ile Cys 
65                  70                  75                  80  


Asp Arg Asn His Thr Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg 
                85                  90                  95      


Glu Thr Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
            100                 105                 110         


Ala Asn Gly Thr Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
        115                 120                 125             


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
    130                 135                 140                 


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
145                 150                 155                 160 


Leu Cys Thr Pro Pro Pro Lys Ile Lys Asn Gly Lys His Thr Phe Ser 
                165                 170                 175     


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Thr Tyr Ser Cys Asp 
            180                 185                 190         


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Thr Ile 
        195                 200                 205             


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
    210                 215                 220                 


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
225                 230                 235                 240 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Thr Val Met Phe Glu Cys 
                245                 250                 255     


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Thr Ile Val Cys Asp Ser 
            260                 265                 270         


Asn Ser Thr Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Gly Tyr Pro 
        275                 280                 285             


Lys Pro Glu Glu Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala 
    290                 295                 300                 


Val Ile Val Ile Ala Ile Val Val Gly Val Ala Val Ile Cys Val Val 
305                 310                 315                 320 


Pro Tyr Arg Tyr Leu Gln Arg Arg Lys Lys Lys Gly Lys Ala Asp Gly 
                325                 330                 335     


Gly Ala Glu Tyr Ala Thr Tyr Gln Thr Lys Ser Thr Thr Pro Ala Glu 
            340                 345                 350         


Gln Arg Gly 
        355 


<210>  6321
<211>  989
<212>  PRT
<213>  Homo sapiens

<400>  6321

Met Thr Met Ala Gly Gly Arg Arg Gly Leu Val Ala Pro Gln Asn Thr 
1               5                   10                  15      


Phe Leu Glu Asn Ile Val Arg Arg Ser Asn Asp Thr Asn Phe Val Leu 
            20                  25                  30          


Gly Asn Ala Gln Ile Val Asp Trp Pro Ile Val Tyr Ser Asn Asp Gly 
        35                  40                  45              


Phe Cys Lys Leu Ser Gly Tyr His Arg Ala Glu Val Met Gln Lys Ser 
    50                  55                  60                  


Ser Thr Cys Ser Phe Met Tyr Gly Glu Leu Thr Asp Lys Asp Thr Ile 
65                  70                  75                  80  


Glu Lys Val Arg Gln Thr Phe Glu Asn Tyr Glu Met Asn Ser Phe Glu 
                85                  90                  95      


Ile Leu Met Tyr Lys Lys Asn Arg Thr Pro Val Trp Phe Phe Val Lys 
            100                 105                 110         


Ile Ala Pro Ile Arg Asn Glu Gln Asp Lys Val Val Leu Phe Leu Cys 
        115                 120                 125             


Thr Phe Ser Asp Ile Thr Ala Phe Lys Gln Pro Ile Glu Asp Asp Ser 
    130                 135                 140                 


Cys Lys Gly Trp Gly Lys Phe Ala Arg Leu Thr Arg Ala Leu Thr Ser 
145                 150                 155                 160 


Ser Arg Gly Val Leu Gln Gln Leu Ala Pro Ser Val Gln Lys Gly Glu 
                165                 170                 175     


Asn Val His Lys His Ser Arg Leu Ala Glu Val Leu Gln Leu Gly Ser 
            180                 185                 190         


Asp Ile Leu Pro Gln Tyr Lys Gln Glu Ala Pro Lys Thr Pro Pro His 
        195                 200                 205             


Ile Ile Leu His Tyr Cys Val Phe Lys Thr Thr Trp Asp Trp Ile Ile 
    210                 215                 220                 


Leu Ile Leu Thr Phe Tyr Thr Ala Ile Leu Val Pro Tyr Asn Val Ser 
225                 230                 235                 240 


Phe Lys Thr Arg Gln Asn Asn Val Ala Trp Leu Val Val Asp Ser Ile 
                245                 250                 255     


Val Asp Val Ile Phe Leu Val Asp Ile Val Leu Asn Phe His Thr Thr 
            260                 265                 270         


Phe Val Gly Pro Ala Gly Glu Val Ile Ser Asp Pro Lys Leu Ile Arg 
        275                 280                 285             


Met Asn Tyr Leu Lys Thr Trp Phe Val Ile Asp Leu Leu Ser Cys Leu 
    290                 295                 300                 


Pro Tyr Asp Val Ile Asn Ala Phe Glu Asn Val Asp Glu Val Ser Ala 
305                 310                 315                 320 


Phe Met Gly Asp Pro Gly Lys Ile Gly Phe Ala Asp Gln Ile Pro Pro 
                325                 330                 335     


Pro Leu Glu Gly Arg Glu Ser Gln Gly Ile Ser Ser Leu Phe Ser Ser 
            340                 345                 350         


Leu Lys Val Val Arg Leu Leu Arg Leu Gly Arg Val Ala Arg Lys Leu 
        355                 360                 365             


Asp His Tyr Ile Glu Tyr Gly Ala Ala Val Leu Val Leu Leu Val Cys 
    370                 375                 380                 


Val Phe Gly Leu Ala Ala His Trp Met Ala Cys Ile Trp Tyr Ser Ile 
385                 390                 395                 400 


Gly Asp Tyr Glu Ile Phe Asp Glu Asp Thr Lys Thr Ile Arg Asn Asn 
                405                 410                 415     


Ser Trp Leu Tyr Gln Leu Ala Met Asp Ile Gly Thr Pro Tyr Gln Phe 
            420                 425                 430         


Asn Gly Ser Gly Ser Gly Lys Trp Glu Gly Gly Pro Ser Lys Asn Ser 
        435                 440                 445             


Val Tyr Ile Ser Ser Leu Tyr Phe Thr Met Thr Ser Leu Thr Ser Val 
    450                 455                 460                 


Gly Phe Gly Asn Ile Ala Pro Ser Thr Asp Ile Glu Lys Ile Phe Ala 
465                 470                 475                 480 


Val Ala Ile Met Met Ile Gly Ser Leu Leu Tyr Ala Thr Ile Phe Gly 
                485                 490                 495     


Asn Val Thr Thr Ile Phe Gln Gln Met Tyr Ala Asn Thr Asn Arg Tyr 
            500                 505                 510         


His Glu Met Leu Asn Ser Val Arg Asp Phe Leu Lys Leu Tyr Gln Val 
        515                 520                 525             


Pro Lys Gly Leu Ser Glu Arg Val Met Asp Tyr Ile Val Ser Thr Trp 
    530                 535                 540                 


Ser Met Ser Arg Gly Ile Asp Thr Glu Lys Val Leu Gln Ile Cys Pro 
545                 550                 555                 560 


Lys Asp Met Arg Ala Asp Ile Cys Val His Leu Asn Arg Lys Val Phe 
                565                 570                 575     


Lys Glu His Pro Ala Phe Arg Leu Ala Ser Asp Gly Cys Leu Arg Ala 
            580                 585                 590         


Leu Ala Met Glu Phe Gln Thr Val His Cys Ala Pro Gly Asp Leu Ile 
        595                 600                 605             


Tyr His Ala Gly Glu Ser Val Asp Ser Leu Cys Phe Val Val Ser Gly 
    610                 615                 620                 


Ser Leu Glu Val Ile Gln Asp Asp Glu Val Val Ala Ile Leu Gly Lys 
625                 630                 635                 640 


Gly Asp Val Phe Gly Asp Val Phe Trp Lys Glu Ala Thr Leu Ala Gln 
                645                 650                 655     


Ser Cys Ala Asn Val Arg Ala Leu Thr Tyr Cys Asp Leu His Val Ile 
            660                 665                 670         


Lys Arg Asp Ala Leu Gln Lys Val Leu Glu Phe Tyr Thr Ala Phe Ser 
        675                 680                 685             


His Ser Phe Ser Arg Asn Leu Ile Leu Thr Tyr Asn Leu Arg Lys Arg 
    690                 695                 700                 


Ile Val Phe Arg Lys Ile Ser Asp Val Lys Arg Glu Glu Glu Glu Arg 
705                 710                 715                 720 


Met Lys Arg Lys Asn Glu Ala Pro Leu Ile Leu Pro Pro Asp His Pro 
                725                 730                 735     


Val Arg Arg Leu Phe Gln Arg Phe Arg Gln Gln Lys Glu Ala Arg Leu 
            740                 745                 750         


Ala Ala Glu Arg Gly Gly Arg Asp Leu Asp Asp Leu Asp Val Glu Lys 
        755                 760                 765             


Gly Asn Val Leu Thr Glu His Ala Ser Ala Asn His Ser Leu Val Lys 
    770                 775                 780                 


Ala Ser Val Val Thr Val Arg Glu Ser Pro Ala Thr Pro Val Ser Phe 
785                 790                 795                 800 


Gln Ala Ala Ser Thr Ser Gly Val Pro Asp His Ala Lys Leu Gln Ala 
                805                 810                 815     


Pro Gly Ser Glu Cys Leu Gly Pro Lys Gly Gly Gly Gly Asp Cys Ala 
            820                 825                 830         


Lys Arg Lys Ser Trp Ala Arg Phe Lys Asp Ala Cys Gly Lys Ser Glu 
        835                 840                 845             


Asp Trp Asn Lys Val Ser Lys Ala Glu Ser Met Glu Thr Leu Pro Glu 
    850                 855                 860                 


Arg Thr Lys Ala Ser Gly Glu Ala Thr Leu Lys Lys Thr Asp Ser Cys 
865                 870                 875                 880 


Asp Ser Gly Ile Thr Lys Ser Asp Leu Arg Leu Asp Asn Val Gly Glu 
                885                 890                 895     


Ala Arg Ser Pro Gln Asp Arg Ser Pro Ile Leu Ala Glu Val Lys His 
            900                 905                 910         


Ser Phe Tyr Pro Ile Pro Glu Gln Thr Leu Gln Ala Thr Val Leu Glu 
        915                 920                 925             


Val Arg His Glu Leu Lys Glu Asp Ile Lys Ala Leu Asn Ala Lys Met 
    930                 935                 940                 


Thr Asn Ile Glu Lys Gln Leu Ser Glu Ile Leu Arg Ile Leu Thr Ser 
945                 950                 955                 960 


Arg Arg Ser Ser Gln Ser Pro Gln Glu Leu Phe Glu Ile Ser Arg Pro 
                965                 970                 975     


Gln Ser Pro Glu Ser Glu Arg Asp Ile Phe Gly Ala Ser 
            980                 985                 


<210>  6322
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  6322

Met Ala His Pro Val Gln Ser Glu Phe Pro Ser Ala Gln Glu Pro Gly 
1               5                   10                  15      


Ser Ala Ala Phe Leu Asp Leu Pro Glu Met Glu Ile Leu Leu Thr Lys 
            20                  25                  30          


Ala Glu Asn Lys Asp Asp Lys Thr Leu Asn Leu Ser Lys Thr Leu Ser 
        35                  40                  45              


Gly Pro Leu Asp Leu Glu Gln Asn Ser Gln Gly Leu Pro Phe Lys Ala 
    50                  55                  60                  


Ile Ser Glu Gly His Leu Glu Ala Pro Leu Pro Arg Ser Pro Ser Arg 
65                  70                  75                  80  


Ala Ser Ser Arg Arg Ala Ser Ser Ile Ala Thr Thr Ser Tyr Ala Gln 
                85                  90                  95      


Asp Gln Glu Ala Pro Arg Asp Tyr Leu Ile Leu Ala Val Val Ala Cys 
            100                 105                 110         


Phe Cys Pro Val Trp Pro Leu Asn Leu Ile Pro Leu Ile Ile Ser Ile 
        115                 120                 125             


Met Ser Arg Ser Ser Met Gln Gln Gly Asn Val Asp Gly Ala Arg Arg 
    130                 135                 140                 


Leu Gly Arg Leu Ala Arg Leu Leu Ser Ile Thr Leu Ile Ile Met Gly 
145                 150                 155                 160 


Ile Val Ile Ile Met Val Ala Val Thr Val Asn Phe Thr Val Gln Lys 
                165                 170                 175     


Lys 
    


<210>  6323
<211>  589
<212>  PRT
<213>  Homo sapiens

<400>  6323

Met Pro Asn Asp Asp Phe Cys Pro Gly Leu Thr Ile Lys Ala Met Gly 
1               5                   10                  15      


Ala Glu Arg Ala Pro Gln Arg Gln Pro Cys Thr Leu His Leu Leu Val 
            20                  25                  30          


Leu Val Pro Ile Leu Leu Ser Leu Val Ala Ser Gln Asp Trp Lys Ala 
        35                  40                  45              


Glu Arg Ser Gln Asp Pro Phe Glu Lys Cys Met Gln Asp Pro Asp Tyr 
    50                  55                  60                  


Glu Gln Leu Leu Lys Val Val Thr Trp Gly Leu Asn Arg Thr Leu Lys 
65                  70                  75                  80  


Pro Gln Arg Val Ile Val Val Gly Ala Gly Val Ala Gly Leu Val Ala 
                85                  90                  95      


Ala Lys Val Leu Ser Asp Ala Gly His Lys Val Thr Ile Leu Glu Ala 
            100                 105                 110         


Asp Asn Arg Ile Gly Gly Arg Ile Phe Thr Tyr Arg Asp Gln Asn Thr 
        115                 120                 125             


Gly Trp Ile Gly Glu Leu Gly Ala Met Arg Met Pro Ser Ser His Arg 
    130                 135                 140                 


Ile Leu His Lys Leu Cys Gln Gly Leu Gly Leu Asn Leu Thr Lys Phe 
145                 150                 155                 160 


Thr Gln Tyr Asp Lys Asn Thr Trp Thr Glu Val His Glu Val Lys Leu 
                165                 170                 175     


Arg Asn Tyr Val Val Glu Lys Val Pro Glu Lys Leu Gly Tyr Ala Leu 
            180                 185                 190         


Arg Pro Gln Glu Lys Gly His Ser Pro Glu Asp Ile Tyr Gln Met Ala 
        195                 200                 205             


Leu Asn Gln Ala Leu Lys Asp Leu Lys Ala Leu Gly Cys Arg Lys Ala 
    210                 215                 220                 


Met Lys Lys Phe Glu Arg His Thr Leu Leu Glu Tyr Leu Leu Gly Glu 
225                 230                 235                 240 


Gly Asn Leu Ser Arg Pro Ala Val Gln Leu Leu Gly Asp Val Met Ser 
                245                 250                 255     


Glu Asp Gly Phe Phe Tyr Leu Ser Phe Ala Glu Ala Leu Arg Ala His 
            260                 265                 270         


Ser Cys Leu Ser Asp Arg Leu Gln Tyr Ser Arg Ile Val Gly Gly Trp 
        275                 280                 285             


Asp Leu Leu Pro Arg Ala Leu Leu Ser Ser Leu Ser Gly Leu Val Leu 
    290                 295                 300                 


Leu Asn Ala Pro Val Val Ala Met Thr Gln Gly Pro His Asp Val His 
305                 310                 315                 320 


Val Gln Ile Glu Thr Ser Pro Pro Ala Arg Asn Leu Lys Val Leu Lys 
                325                 330                 335     


Ala Asp Val Val Leu Leu Thr Ala Ser Gly Pro Ala Val Lys Arg Ile 
            340                 345                 350         


Thr Phe Ser Pro Pro Leu Pro Arg His Met Gln Glu Ala Leu Arg Arg 
        355                 360                 365             


Leu His Tyr Val Pro Ala Thr Lys Val Phe Leu Ser Phe Arg Arg Pro 
    370                 375                 380                 


Phe Trp Arg Glu Glu His Ile Glu Gly Gly His Ser Asn Thr Asp Arg 
385                 390                 395                 400 


Pro Ser Arg Met Ile Phe Tyr Pro Pro Pro Arg Glu Gly Ala Leu Leu 
                405                 410                 415     


Leu Ala Ser Tyr Thr Trp Ser Asp Ala Ala Ala Ala Phe Ala Gly Leu 
            420                 425                 430         


Ser Arg Glu Glu Ala Leu Arg Leu Ala Leu Asp Asp Val Ala Ala Leu 
        435                 440                 445             


His Gly Pro Val Val Arg Gln Leu Trp Asp Gly Thr Gly Val Val Lys 
    450                 455                 460                 


Arg Trp Ala Glu Asp Gln His Ser Gln Gly Gly Phe Val Val Gln Pro 
465                 470                 475                 480 


Pro Ala Leu Trp Gln Thr Glu Lys Asp Asp Trp Thr Val Pro Tyr Gly 
                485                 490                 495     


Arg Ile Tyr Phe Ala Gly Glu His Thr Ala Tyr Pro His Gly Trp Val 
            500                 505                 510         


Glu Thr Ala Val Lys Ser Ala Leu Arg Ala Ala Ile Lys Ile Asn Ser 
        515                 520                 525             


Arg Lys Gly Pro Ala Ser Asp Thr Ala Ser Pro Glu Gly His Ala Ser 
    530                 535                 540                 


Asp Met Glu Gly Gln Gly His Val His Gly Val Ala Ser Ser Pro Ser 
545                 550                 555                 560 


His Asp Leu Ala Lys Glu Glu Gly Ser His Pro Pro Val Gln Gly Gln 
                565                 570                 575     


Leu Ser Leu Gln Asn Thr Thr His Thr Arg Thr Ser His 
            580                 585                 


<210>  6324
<211>  611
<212>  PRT
<213>  Homo sapiens

<400>  6324

Met Pro Gly Gly Lys Arg Gly Leu Val Ala Pro Gln Asn Thr Phe Leu 
1               5                   10                  15      


Glu Asn Ile Val Arg Arg Ser Ser Glu Ser Ser Phe Leu Leu Gly Asn 
            20                  25                  30          


Ala Gln Ile Val Asp Trp Pro Val Val Tyr Ser Asn Asp Gly Phe Cys 
        35                  40                  45              


Lys Leu Ser Gly Tyr His Arg Ala Asp Val Met Gln Lys Ser Ser Thr 
    50                  55                  60                  


Cys Ser Phe Met Tyr Gly Glu Leu Thr Asp Lys Lys Thr Ile Glu Lys 
65                  70                  75                  80  


Val Arg Gln Thr Phe Asp Asn Tyr Glu Ser Asn Cys Phe Glu Val Leu 
                85                  90                  95      


Leu Tyr Lys Lys Asn Arg Thr Pro Val Trp Phe Tyr Met Gln Ile Ala 
            100                 105                 110         


Pro Ile Arg Asn Glu His Glu Lys Val Val Leu Phe Leu Cys Thr Phe 
        115                 120                 125             


Lys Asp Ile Thr Leu Phe Lys Gln Pro Ile Glu Asp Asp Ser Thr Lys 
    130                 135                 140                 


Gly Trp Thr Lys Phe Ala Arg Leu Thr Arg Ala Leu Thr Asn Ser Arg 
145                 150                 155                 160 


Ser Val Leu Gln Gln Leu Thr Pro Met Asn Lys Thr Glu Val Val His 
                165                 170                 175     


Lys His Ser Arg Leu Ala Glu Val Leu Gln Leu Gly Ser Asp Ile Leu 
            180                 185                 190         


Pro Gln Tyr Lys Gln Glu Ala Pro Lys Thr Pro Pro His Ile Ile Leu 
        195                 200                 205             


His Tyr Cys Ala Phe Lys Thr Thr Trp Asp Trp Val Ile Leu Ile Leu 
    210                 215                 220                 


Thr Phe Tyr Thr Ala Ile Met Val Pro Tyr Asn Val Ser Phe Lys Thr 
225                 230                 235                 240 


Lys Gln Asn Asn Ile Ala Trp Leu Val Leu Asp Ser Val Val Asp Val 
                245                 250                 255     


Ile Phe Leu Val Asp Ile Val Leu Asn Phe His Thr Thr Phe Val Gly 
            260                 265                 270         


Pro Gly Gly Glu Val Ile Ser Asp Pro Lys Leu Ile Arg Met Asn Tyr 
        275                 280                 285             


Leu Lys Thr Trp Phe Val Ile Asp Leu Leu Ser Cys Leu Pro Tyr Asp 
    290                 295                 300                 


Ile Ile Asn Ala Phe Glu Asn Val Asp Glu Gly Ile Ser Ser Leu Phe 
305                 310                 315                 320 


Ser Ser Leu Lys Val Val Arg Leu Leu Arg Leu Gly Arg Val Ala Arg 
                325                 330                 335     


Lys Leu Asp His Tyr Leu Glu Tyr Gly Ala Ala Val Leu Val Leu Leu 
            340                 345                 350         


Val Cys Val Phe Gly Leu Val Ala His Trp Leu Ala Cys Ile Trp Tyr 
        355                 360                 365             


Ser Ile Gly Asp Tyr Glu Val Ile Asp Glu Val Thr Asn Thr Ile Gln 
    370                 375                 380                 


Ile Asp Ser Trp Leu Tyr Gln Leu Ala Leu Ser Ile Gly Thr Pro Tyr 
385                 390                 395                 400 


Arg Tyr Asn Thr Ser Ala Gly Ile Trp Glu Gly Gly Pro Ser Lys Asp 
                405                 410                 415     


Ser Leu Tyr Val Ser Ser Leu Tyr Phe Thr Met Thr Ser Leu Thr Thr 
            420                 425                 430         


Ile Gly Phe Gly Asn Ile Ala Pro Thr Thr Asp Val Glu Lys Met Phe 
        435                 440                 445             


Ser Val Ala Met Met Met Val Gly Ser Leu Leu Tyr Ala Thr Ile Phe 
    450                 455                 460                 


Gly Asn Val Thr Thr Ile Phe Gln Gln Met Tyr Ala Asn Thr Asn Arg 
465                 470                 475                 480 


Tyr His Glu Met Leu Asn Asn Val Arg Asp Phe Leu Lys Leu Tyr Gln 
                485                 490                 495     


Val Pro Lys Gly Leu Ser Glu Arg Val Met Asp Tyr Ile Val Ser Thr 
            500                 505                 510         


Trp Ser Met Ser Lys Gly Ile Asp Thr Glu Lys Val Leu Ser Ile Cys 
        515                 520                 525             


Pro Lys Asp Met Arg Ala Asp Ile Cys Val His Leu Asn Arg Lys Val 
    530                 535                 540                 


Phe Asn Glu His Pro Ala Phe Arg Leu Ala Ser Asp Gly Cys Leu Arg 
545                 550                 555                 560 


Ala Leu Ala Val Glu Phe Gln Thr Ile His Cys Ala Pro Gly Asp Leu 
                565                 570                 575     


Ile Tyr His Ala Gly Glu Ser Val Asp Ala Leu Cys Phe Val Val Ser 
            580                 585                 590         


Gly Ser Leu Glu Val Ile Gln Asp Asp Glu Val Val Ala Ile Leu Asp 
        595                 600                 605             


His Leu Ser 
    610     


<210>  6325
<211>  611
<212>  PRT
<213>  Homo sapiens

<400>  6325

Met Pro Gly Gly Lys Arg Gly Leu Val Ala Pro Gln Asn Thr Phe Leu 
1               5                   10                  15      


Glu Asn Ile Val Arg Arg Ser Ser Glu Ser Ser Phe Leu Leu Gly Asn 
            20                  25                  30          


Ala Gln Ile Val Asp Trp Pro Val Val Tyr Ser Asn Asp Gly Phe Cys 
        35                  40                  45              


Lys Leu Ser Gly Tyr His Arg Ala Asp Val Met Gln Lys Ser Ser Thr 
    50                  55                  60                  


Cys Ser Phe Met Tyr Gly Glu Leu Thr Asp Lys Lys Thr Ile Glu Lys 
65                  70                  75                  80  


Val Arg Gln Thr Phe Asp Asn Tyr Glu Ser Asn Cys Phe Glu Val Leu 
                85                  90                  95      


Leu Tyr Lys Lys Asn Arg Thr Pro Val Trp Phe Tyr Met Gln Ile Ala 
            100                 105                 110         


Pro Ile Arg Asn Glu His Glu Lys Val Val Leu Phe Leu Cys Thr Phe 
        115                 120                 125             


Lys Asp Ile Thr Leu Phe Lys Gln Pro Ile Glu Asp Asp Ser Thr Lys 
    130                 135                 140                 


Gly Trp Thr Lys Phe Ala Arg Leu Thr Arg Ala Leu Thr Asn Ser Arg 
145                 150                 155                 160 


Ser Val Leu Gln Gln Leu Thr Pro Met Asn Lys Thr Glu Val Val His 
                165                 170                 175     


Lys His Ser Arg Leu Ala Glu Val Leu Gln Leu Gly Ser Asp Ile Leu 
            180                 185                 190         


Pro Gln Tyr Lys Gln Glu Ala Pro Lys Thr Pro Pro His Ile Ile Leu 
        195                 200                 205             


His Tyr Cys Ala Phe Lys Thr Thr Trp Asp Trp Val Ile Leu Ile Leu 
    210                 215                 220                 


Thr Phe Tyr Thr Ala Ile Met Val Pro Tyr Asn Val Ser Phe Lys Thr 
225                 230                 235                 240 


Lys Gln Asn Asn Ile Ala Trp Leu Val Leu Asp Ser Val Val Asp Val 
                245                 250                 255     


Ile Phe Leu Val Asp Ile Val Leu Asn Phe His Thr Thr Phe Val Gly 
            260                 265                 270         


Pro Gly Gly Glu Val Ile Ser Asp Pro Lys Leu Ile Arg Met Asn Tyr 
        275                 280                 285             


Leu Lys Thr Trp Phe Val Ile Asp Leu Leu Ser Cys Leu Pro Tyr Asp 
    290                 295                 300                 


Ile Ile Asn Ala Phe Glu Asn Val Asp Glu Gly Ile Ser Ser Leu Phe 
305                 310                 315                 320 


Ser Ser Leu Lys Val Val Arg Leu Leu Arg Leu Gly Arg Val Ala Arg 
                325                 330                 335     


Lys Leu Asp His Tyr Leu Glu Tyr Gly Ala Ala Val Leu Val Leu Leu 
            340                 345                 350         


Val Cys Val Phe Gly Leu Val Ala His Trp Leu Ala Cys Ile Trp Tyr 
        355                 360                 365             


Ser Ile Gly Asp Tyr Glu Val Ile Asp Glu Val Thr Asn Thr Ile Gln 
    370                 375                 380                 


Ile Asp Ser Trp Leu Tyr Gln Leu Ala Leu Ser Ile Gly Thr Pro Tyr 
385                 390                 395                 400 


Arg Tyr Asn Thr Ser Ala Gly Ile Trp Glu Gly Gly Pro Ser Lys Asp 
                405                 410                 415     


Ser Leu Tyr Val Ser Ser Leu Tyr Phe Thr Met Thr Ser Leu Thr Thr 
            420                 425                 430         


Ile Gly Phe Gly Asn Ile Ala Pro Thr Thr Asp Val Glu Lys Met Phe 
        435                 440                 445             


Ser Val Ala Met Met Met Val Gly Ser Leu Leu Tyr Ala Thr Ile Phe 
    450                 455                 460                 


Gly Asn Val Thr Thr Ile Phe Gln Gln Met Tyr Ala Asn Thr Asn Arg 
465                 470                 475                 480 


Tyr His Glu Met Leu Asn Asn Val Arg Asp Phe Leu Lys Leu Tyr Gln 
                485                 490                 495     


Val Pro Lys Gly Leu Ser Glu Arg Val Met Asp Tyr Ile Val Ser Thr 
            500                 505                 510         


Trp Ser Met Ser Lys Gly Ile Asp Thr Glu Lys Val Leu Ser Ile Cys 
        515                 520                 525             


Pro Lys Asp Met Arg Ala Asp Ile Cys Val His Leu Asn Arg Lys Val 
    530                 535                 540                 


Phe Asn Glu His Pro Ala Phe Arg Leu Ala Ser Asp Gly Cys Leu Arg 
545                 550                 555                 560 


Ala Leu Ala Val Glu Phe Gln Thr Ile His Cys Ala Pro Gly Asp Leu 
                565                 570                 575     


Ile Tyr His Ala Gly Glu Ser Val Asp Ala Leu Cys Phe Val Val Ser 
            580                 585                 590         


Gly Ser Leu Glu Val Ile Gln Asp Asp Glu Val Val Ala Ile Leu Asp 
        595                 600                 605             


His Leu Ser 
    610     


<210>  6326
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  6326

Met Ser Pro Leu Leu Gly Leu Arg Ser Glu Leu Gln Asp Thr Cys Thr 
1               5                   10                  15      


Ser Leu Gly Leu Met Leu Ser Val Val Leu Leu Met Gly Leu Ala Arg 
            20                  25                  30          


Val Val Ala Arg Gln Gln Leu His Arg Pro Val Ala His Ala Phe Val 
        35                  40                  45              


Leu Glu Phe Leu Ala Thr Phe Gln Leu Cys Cys Cys Thr His Glu Leu 
    50                  55                  60                  


Gln Leu Leu Ser Glu Gln His Pro Ala His Pro Thr Trp Thr Leu Thr 
65                  70                  75                  80  


Leu Val Tyr Phe Phe Ser Leu Val His Gly Leu Thr Leu Val Gly Thr 
                85                  90                  95      


Ser Ser Asn Pro Cys Gly Val Met Met Gln Met Met Leu Gly Gly Met 
            100                 105                 110         


Ser Pro Glu Thr Gly Ala Val Arg Leu Leu Ala Gln Leu Val Ser Ala 
        115                 120                 125             


Leu Cys Ser Arg Tyr Cys Thr Ser Ala Leu Trp Ser Leu Gly Leu Thr 
    130                 135                 140                 


Gln Tyr His Val Ser Glu Arg Ser Phe Ala Cys Lys Asn Pro Ile Arg 
145                 150                 155                 160 


Val Asp Leu Leu Lys Ala Val Ile Thr Glu Ala Val Cys Ser Phe Leu 
                165                 170                 175     


Phe His Ser Ala Leu Leu His Phe Gln Glu Val Arg Thr Lys Leu Arg 
            180                 185                 190         


Ile His Leu Leu Ala Ala Leu Ile Thr Phe Leu Val Tyr Ala Gly Gly 
        195                 200                 205             


Ser Leu Thr Gly Ala Val Phe Asn Pro Ala Leu Ala Leu Ser Leu His 
    210                 215                 220                 


Phe Met Cys Phe Asp Glu Ala Phe Pro Gln Phe Phe Ile Val Tyr Trp 
225                 230                 235                 240 


Leu Ala Pro Ser Leu Gly Ile Leu Leu Met Ile Leu Met Phe Ser Phe 
                245                 250                 255     


Phe Leu Pro Trp Leu His Asn Asn His Thr Ile Asn Lys Lys Glu 
            260                 265                 270     


<210>  6327
<211>  2721
<212>  PRT
<213>  Homo sapiens

<400>  6327

Met Val Pro Pro Val Trp Thr Leu Leu Leu Leu Val Gly Ala Ala Leu 
1               5                   10                  15      


Phe Arg Lys Glu Lys Pro Pro Asp Gln Lys Leu Val Val Arg Ser Ser 
            20                  25                  30          


Arg Asp Asn Tyr Val Leu Thr Gln Cys Asp Phe Glu Asp Asp Ala Lys 
        35                  40                  45              


Pro Leu Cys Asp Trp Ser Gln Val Ser Ala Asp Asp Glu Asp Trp Val 
    50                  55                  60                  


Arg Ala Ser Gly Pro Ser Pro Thr Gly Ser Thr Gly Ala Pro Gly Gly 
65                  70                  75                  80  


Tyr Pro Asn Gly Glu Gly Ser Tyr Leu His Met Glu Ser Asn Ser Phe 
                85                  90                  95      


His Arg Gly Gly Val Ala Arg Leu Leu Ser Pro Asp Leu Trp Glu Gln 
            100                 105                 110         


Gly Pro Leu Cys Val His Phe Ala His His Met Phe Gly Leu Ser Trp 
        115                 120                 125             


Gly Ala Gln Leu Arg Leu Leu Leu Leu Ser Gly Glu Glu Gly Arg Arg 
    130                 135                 140                 


Pro Asp Val Leu Trp Lys His Trp Asn Thr Gln Arg Pro Ser Trp Met 
145                 150                 155                 160 


Leu Thr Thr Val Thr Val Pro Ala Gly Phe Thr Leu Pro Thr Arg Leu 
                165                 170                 175     


Met Phe Glu Gly Thr Arg Gly Ser Thr Ala Tyr Leu Asp Ile Ala Leu 
            180                 185                 190         


Asp Ala Leu Ser Ile Arg Arg Gly Ser Cys Asn Arg Val Cys Met Met 
        195                 200                 205             


Gln Thr Cys Ser Phe Asp Ile Pro Asn Asp Leu Cys Asp Trp Thr Trp 
    210                 215                 220                 


Ile Pro Thr Ala Ser Gly Ala Lys Trp Thr Gln Lys Lys Gly Ser Ser 
225                 230                 235                 240 


Gly Lys Pro Gly Val Gly Pro Asp Gly Asp Phe Ser Ser Pro Gly Ser 
                245                 250                 255     


Gly Cys Tyr Met Leu Leu Asp Pro Lys Asn Ala Arg Pro Gly Gln Lys 
            260                 265                 270         


Ala Val Leu Leu Ser Pro Val Ser Leu Ser Ser Gly Cys Leu Ser Phe 
        275                 280                 285             


Ser Phe His Tyr Ile Leu Arg Gly Gln Ser Pro Gly Ala Ala Leu His 
    290                 295                 300                 


Ile Tyr Ala Ser Val Leu Gly Ser Ile Arg Lys His Thr Leu Phe Ser 
305                 310                 315                 320 


Gly Gln Pro Gly Pro Asn Trp Gln Ala Val Ser Val Asn Tyr Thr Ala 
                325                 330                 335     


Val Gly Arg Ile Gln Phe Ala Val Val Gly Val Phe Gly Lys Thr Pro 
            340                 345                 350         


Glu Pro Ala Val Ala Val Asp Ala Thr Ser Ile Ala Pro Cys Gly Glu 
        355                 360                 365             


Gly Phe Pro Gln Cys Asp Phe Glu Asp Asn Ala His Pro Phe Cys Asp 
    370                 375                 380                 


Trp Val Gln Thr Ser Gly Asp Gly Gly His Trp Ala Leu Gly His Lys 
385                 390                 395                 400 


Asn Gly Pro Val His Gly Met Gly Pro Ala Gly Gly Phe Pro Asn Ala 
                405                 410                 415     


Gly Gly His Tyr Ile Tyr Leu Glu Ala Asp Glu Phe Ser Gln Ala Gly 
            420                 425                 430         


Gln Ser Val Arg Leu Val Ser Arg Pro Phe Cys Ala Pro Gly Asp Ile 
        435                 440                 445             


Cys Val Glu Phe Ala Tyr His Met Tyr Gly Leu Gly Glu Gly Thr Met 
    450                 455                 460                 


Leu Glu Leu Leu Leu Gly Ser Pro Ala Gly Ser Pro Pro Ile Pro Leu 
465                 470                 475                 480 


Trp Lys Arg Val Gly Ser Gln Arg Pro Tyr Trp Gln Asn Thr Ser Val 
                485                 490                 495     


Thr Val Pro Ser Gly His Gln Gln Pro Met Gln Leu Ile Phe Lys Gly 
            500                 505                 510         


Ile Gln Gly Ser Asn Thr Ala Ser Val Val Ala Met Gly Phe Ile Leu 
        515                 520                 525             


Ile Asn Pro Gly Thr Cys Pro Val Lys Val Leu Pro Glu Leu Pro Pro 
    530                 535                 540                 


Val Ser Pro Val Ser Ser Thr Gly Pro Ser Glu Thr Thr Gly Leu Thr 
545                 550                 555                 560 


Glu Asn Pro Thr Ile Ser Thr Lys Lys Pro Thr Val Ser Ile Glu Lys 
                565                 570                 575     


Pro Ser Val Thr Thr Glu Lys Pro Thr Val Pro Lys Glu Lys Pro Thr 
            580                 585                 590         


Ile Pro Thr Glu Lys Pro Thr Ile Ser Thr Glu Lys Pro Thr Ile Pro 
        595                 600                 605             


Ser Glu Lys Pro Asn Met Pro Ser Glu Lys Pro Thr Ile Pro Ser Glu 
    610                 615                 620                 


Lys Pro Thr Ile Leu Thr Glu Lys Pro Thr Ile Pro Ser Glu Lys Pro 
625                 630                 635                 640 


Thr Ile Pro Ser Glu Lys Pro Thr Ile Ser Thr Glu Lys Pro Thr Val 
                645                 650                 655     


Pro Thr Glu Glu Pro Thr Thr Pro Thr Glu Glu Thr Thr Thr Ser Met 
            660                 665                 670         


Glu Glu Pro Val Ile Pro Thr Glu Lys Pro Ser Ile Pro Thr Glu Lys 
        675                 680                 685             


Pro Ser Ile Pro Thr Glu Lys Pro Thr Ile Ser Met Glu Glu Thr Ile 
    690                 695                 700                 


Ile Ser Thr Glu Lys Pro Thr Ile Ser Pro Glu Lys Pro Thr Ile Pro 
705                 710                 715                 720 


Thr Glu Lys Pro Thr Ile Pro Thr Glu Lys Ser Thr Ile Ser Pro Glu 
                725                 730                 735     


Lys Pro Thr Thr Pro Thr Glu Lys Pro Thr Ile Pro Thr Glu Lys Pro 
            740                 745                 750         


Thr Ile Ser Pro Glu Lys Pro Thr Thr Pro Thr Glu Lys Pro Thr Ile 
        755                 760                 765             


Ser Pro Glu Lys Leu Thr Ile Pro Thr Glu Lys Pro Thr Ile Pro Thr 
    770                 775                 780                 


Glu Lys Pro Thr Ile Pro Thr Glu Lys Pro Thr Ile Ser Thr Glu Glu 
785                 790                 795                 800 


Pro Thr Thr Pro Thr Glu Glu Thr Thr Ile Ser Thr Glu Lys Pro Ser 
                805                 810                 815     


Ile Pro Met Glu Lys Pro Thr Leu Pro Thr Glu Glu Thr Thr Thr Ser 
            820                 825                 830         


Val Glu Glu Thr Thr Ile Ser Thr Glu Lys Leu Thr Ile Pro Met Glu 
        835                 840                 845             


Lys Pro Thr Ile Ser Thr Glu Lys Pro Thr Ile Pro Thr Glu Lys Pro 
    850                 855                 860                 


Thr Ile Ser Pro Glu Lys Leu Thr Ile Pro Thr Glu Lys Leu Thr Ile 
865                 870                 875                 880 


Pro Thr Glu Lys Pro Thr Ile Pro Ile Glu Glu Thr Thr Ile Ser Thr 
                885                 890                 895     


Glu Lys Leu Thr Ile Pro Thr Glu Lys Pro Thr Ile Ser Pro Glu Lys 
            900                 905                 910         


Pro Thr Ile Ser Thr Glu Lys Pro Thr Ile Pro Thr Glu Lys Pro Thr 
        915                 920                 925             


Ile Pro Thr Glu Glu Thr Thr Ile Ser Thr Glu Lys Leu Thr Ile Pro 
    930                 935                 940                 


Thr Glu Lys Pro Thr Ile Ser Pro Glu Lys Leu Thr Ile Pro Thr Glu 
945                 950                 955                 960 


Lys Pro Thr Ile Ser Thr Glu Lys Pro Thr Ile Pro Thr Glu Lys Leu 
                965                 970                 975     


Thr Ile Pro Thr Glu Lys Pro Thr Ile Pro Thr Glu Lys Pro Thr Ile 
            980                 985                 990         


Pro Thr Glu Lys Leu Thr Ala Leu  Arg Pro Pro His Pro  Ser Pro Thr 
        995                 1000                 1005             


Ala Thr  Gly Leu Ala Ala Leu  Val Met Ser Pro His  Ala Pro Ser 
    1010                 1015                 1020             


Thr Pro  Met Thr Ser Val Ile  Leu Gly Thr Thr Thr  Thr Ser Arg 
    1025                 1030                 1035             


Ser Ser  Thr Glu Arg Cys Pro  Pro Asn Ala Arg Tyr  Glu Ser Cys 
    1040                 1045                 1050             


Ala Cys  Pro Ala Ser Cys Lys  Ser Pro Arg Pro Ser  Cys Gly Pro 
    1055                 1060                 1065             


Leu Cys  Arg Glu Gly Cys Val  Cys Asn Pro Gly Phe  Leu Phe Ser 
    1070                 1075                 1080             


Asp Asn  His Cys Ile Gln Ala  Ser Ser Cys Asn Cys  Phe Tyr Asn 
    1085                 1090                 1095             


Asn Asp  Tyr Tyr Glu Pro Gly  Ala Glu Trp Phe Ser  Pro Asn Cys 
    1100                 1105                 1110             


Thr Glu  His Cys Arg Cys Trp  Pro Gly Ser Arg Val  Glu Cys Gln 
    1115                 1120                 1125             


Ile Ser  Gln Cys Gly Thr His  Thr Val Cys Gln Leu  Lys Asn Gly 
    1130                 1135                 1140             


Gln Tyr  Gly Cys His Pro Tyr  Ala Gly Thr Ala Thr  Cys Leu Val 
    1145                 1150                 1155             


Tyr Gly  Asp Pro His Tyr Val  Thr Phe Asp Gly Arg  His Phe Gly 
    1160                 1165                 1170             


Phe Met  Gly Lys Cys Thr Tyr  Ile Leu Ala Gln Pro  Cys Gly Asn 
    1175                 1180                 1185             


Ser Thr  Asp Pro Phe Phe Arg  Val Thr Ala Lys Asn  Glu Glu Gln 
    1190                 1195                 1200             


Gly Gln  Glu Gly Val Ser Cys  Leu Ser Lys Val Tyr  Val Thr Leu 
    1205                 1210                 1215             


Pro Glu  Ser Thr Val Thr Leu  Leu Lys Gly Arg Arg  Thr Leu Val 
    1220                 1225                 1230             


Gly Gly  Gln Gln Val Thr Leu  Pro Ala Ile Pro Ser  Lys Gly Val 
    1235                 1240                 1245             


Phe Leu  Gly Ala Ser Gly Arg  Phe Val Glu Leu Gln  Thr Glu Phe 
    1250                 1255                 1260             


Gly Leu  Arg Val Arg Trp Asp  Gly Asp Gln Gln Leu  Tyr Val Thr 
    1265                 1270                 1275             


Val Ser  Ser Thr Tyr Ser Gly  Lys Leu Cys Gly Leu  Cys Gly Asn 
    1280                 1285                 1290             


Tyr Asp  Gly Asn Ser Asp Asn  Asp His Leu Lys Leu  Asp Gly Ser 
    1295                 1300                 1305             


Pro Ala  Gly Asp Lys Glu Glu  Leu Gly Asn Ser Trp  Gln Thr Asp 
    1310                 1315                 1320             


Gln Asp  Glu Asp Gln Glu Cys  Gln Lys Tyr Gln Val  Val Asn Ser 
    1325                 1330                 1335             


Pro Ser  Cys Asp Ser Ser Leu  Gln Ser Ser Met Ser  Gly Pro Gly 
    1340                 1345                 1350             


Phe Cys  Gly Arg Leu Val Asp  Thr His Gly Pro Phe  Glu Thr Cys 
    1355                 1360                 1365             


Leu Leu  His Val Lys Ala Ala  Ser Phe Phe Asp Ser  Cys Met Leu 
    1370                 1375                 1380             


Asp Met  Cys Gly Phe Gln Gly  Leu Gln His Leu Leu  Cys Thr His 
    1385                 1390                 1395             


Met Ser  Thr Met Thr Thr Thr  Cys Gln Asp Ala Gly  His Ala Val 
    1400                 1405                 1410             


Lys Pro  Trp Arg Glu Pro His  Phe Cys Pro Met Ala  Cys Pro Pro 
    1415                 1420                 1425             


Asn Ser  Lys Tyr Ser Leu Cys  Ala Lys Pro Cys Pro  Asp Thr Cys 
    1430                 1435                 1440             


His Ser  Gly Phe Ser Gly Met  Phe Cys Ser Asp Arg  Cys Val Glu 
    1445                 1450                 1455             


Ala Cys  Glu Cys Asn Pro Gly  Phe Val Leu Ser Gly  Leu Glu Cys 
    1460                 1465                 1470             


Ile Pro  Arg Ser Gln Cys Gly  Cys Leu His Pro Ala  Gly Ser Tyr 
    1475                 1480                 1485             


Phe Lys  Val Gly Glu Arg Trp  Tyr Lys Pro Gly Cys  Lys Glu Leu 
    1490                 1495                 1500             


Cys Val  Cys Glu Ser Asn Asn  Arg Ile Arg Cys Gln  Pro Trp Arg 
    1505                 1510                 1515             


Cys Arg  Ala Gln Glu Phe Cys  Gly Gln Gln Asp Gly  Ile Tyr Gly 
    1520                 1525                 1530             


Cys His  Ala Gln Gly Ala Ala  Thr Cys Thr Ala Ser  Gly Asp Pro 
    1535                 1540                 1545             


His Tyr  Leu Thr Phe Asp Gly  Ala Leu His His Phe  Met Gly Thr 
    1550                 1555                 1560             


Cys Thr  Tyr Val Leu Thr Arg  Pro Cys Trp Ser Arg  Ser Gln Asp 
    1565                 1570                 1575             


Ser Tyr  Phe Val Val Ser Ala  Thr Asn Glu Asn Arg  Gly Gly Ile 
    1580                 1585                 1590             


Leu Glu  Val Ser Tyr Ile Lys  Ala Val His Val Thr  Val Phe Asp 
    1595                 1600                 1605             


Leu Ser  Ile Ser Leu Leu Arg  Gly Cys Lys Val Met  Leu Asn Gly 
    1610                 1615                 1620             


His Arg  Val Ala Leu Pro Val  Trp Leu Ala Gln Gly  Arg Val Thr 
    1625                 1630                 1635             


Ile Arg  Leu Ser Ser Asn Leu  Val Leu Leu Tyr Thr  Asn Phe Gly 
    1640                 1645                 1650             


Leu Gln  Val Arg Tyr Asp Gly  Ser His Leu Val Glu  Val Thr Val 
    1655                 1660                 1665             


Pro Ser  Ser Tyr Gly Gly Gln  Leu Cys Gly Leu Cys  Gly Asn Tyr 
    1670                 1675                 1680             


Asn Asn  Asn Ser Leu Asp Asp  Asn Leu Arg Pro Asp  Arg Lys Leu 
    1685                 1690                 1695             


Ala Gly  Asp Ser Met Gln Leu  Gly Ala Ala Trp Lys  Leu Pro Glu 
    1700                 1705                 1710             


Ser Ser  Glu Pro Gly Cys Phe  Leu Val Gly Gly Lys  Pro Ser Ser 
    1715                 1720                 1725             


Cys Gln  Glu Asn Ser Met Ala  Asp Ala Trp Asn Lys  Asn Cys Ala 
    1730                 1735                 1740             


Ile Leu  Ile Asn Pro Gln Gly  Pro Phe Ser Gln Cys  His Gln Val 
    1745                 1750                 1755             


Val Pro  Pro Gln Ser Ser Phe  Ala Ser Cys Val His  Gly Gln Cys 
    1760                 1765                 1770             


Gly Thr  Lys Gly Asp Thr Thr  Ala Leu Cys Arg Ser  Leu Gln Ala 
    1775                 1780                 1785             


Tyr Ala  Ser Leu Cys Ala Gln  Ala Gly Gln Ala Pro  Ala Trp Arg 
    1790                 1795                 1800             


Asn Arg  Thr Phe Cys Pro Met  Arg Cys Pro Pro Gly  Ser Ser Tyr 
    1805                 1810                 1815             


Ser Pro  Cys Ser Ser Pro Cys  Pro Asp Thr Cys Ser  Ser Ile Asn 
    1820                 1825                 1830             


Asn Pro  Arg Asp Cys Pro Lys  Ala Leu Pro Cys Ala  Glu Ser Cys 
    1835                 1840                 1845             


Glu Cys  Gln Lys Gly His Ile  Leu Ser Gly Thr Ser  Cys Val Pro 
    1850                 1855                 1860             


Leu Gly  Gln Cys Gly Cys Thr  Asp Pro Ala Gly Ser  Tyr His Pro 
    1865                 1870                 1875             


Val Gly  Glu Arg Trp Tyr Thr  Glu Asn Thr Cys Thr  Arg Leu Cys 
    1880                 1885                 1890             


Thr Cys  Ser Val His Asn Asn  Ile Thr Cys Phe Gln  Ser Thr Cys 
    1895                 1900                 1905             


Lys Pro  Asn Gln Ile Cys Trp  Ala Leu Asp Gly Leu  Leu His Cys 
    1910                 1915                 1920             


Arg Ala  Ser Gly Val Gly Val  Cys Gln Leu Pro Gly  Glu Ser His 
    1925                 1930                 1935             


Tyr Val  Ser Phe Asp Gly Ser  Asn His Ser Ile Pro  Asp Ala Cys 
    1940                 1945                 1950             


Thr Leu  Val Leu Val Lys Val  Cys His Pro Ala Met  Ala Leu Pro 
    1955                 1960                 1965             


Phe Phe  Lys Ile Ser Ala Lys  His Glu Lys Glu Glu  Gly Gly Thr 
    1970                 1975                 1980             


Glu Ala  Phe Arg Leu His Glu  Val Tyr Ile Asp Ile  Tyr Asp Ala 
    1985                 1990                 1995             


Gln Val  Thr Leu Gln Lys Gly  His Arg Val Leu Ile  Asn Ser Lys 
    2000                 2005                 2010             


Gln Val  Thr Leu Pro Ala Ile  Ser Gln Ile Pro Gly  Val Ser Val 
    2015                 2020                 2025             


Lys Ser  Ser Ser Ile Tyr Ser  Ile Val Asn Ile Lys  Ile Gly Val 
    2030                 2035                 2040             


Gln Val  Lys Phe Asp Gly Asn  His Leu Leu Glu Ile  Glu Ile Pro 
    2045                 2050                 2055             


Thr Thr  Tyr Tyr Gly Lys Val  Cys Gly Met Cys Gly  Asn Phe Asn 
    2060                 2065                 2070             


Asp Glu  Glu Glu Asp Glu Leu  Met Met Pro Ser Asp  Glu Val Ala 
    2075                 2080                 2085             


Asn Ser  Asp Ser Glu Phe Val  Asn Ser Trp Lys Asp  Lys Asp Ile 
    2090                 2095                 2100             


Asp Pro  Ser Cys Gln Ser Leu  Leu Val Asp Glu Gln  Gln Ile Pro 
    2105                 2110                 2115             


Ala Glu  Gln Gln Glu Asn Pro  Ser Gly Asn Cys Arg  Ala Ala Asp 
    2120                 2125                 2130             


Leu Arg  Arg Ala Arg Glu Lys  Cys Glu Ala Ala Leu  Arg Ala Pro 
    2135                 2140                 2145             


Val Trp  Ala Gln Cys Ala Ser  Arg Ile Asp Leu Thr  Pro Phe Leu 
    2150                 2155                 2160             


Val Asp  Cys Ala Asn Thr Leu  Cys Glu Phe Gly Gly  Leu Tyr Gln 
    2165                 2170                 2175             


Ala Leu  Cys Gln Ala Leu Gln  Ala Phe Gly Ala Thr  Cys Gln Ser 
    2180                 2185                 2190             


Gln Gly  Leu Lys Pro Pro Leu  Trp Arg Asn Ser Ser  Phe Cys Pro 
    2195                 2200                 2205             


Leu Glu  Cys Pro Ala Tyr Ser  Ser Tyr Thr Asn Cys  Leu Pro Ser 
    2210                 2215                 2220             


Cys Ser  Pro Ser Cys Trp Asp  Leu Asp Gly Arg Cys  Glu Gly Ala 
    2225                 2230                 2235             


Lys Val  Pro Ser Ala Cys Ala  Glu Gly Cys Ile Cys  Gln Pro Gly 
    2240                 2245                 2250             


Tyr Val  Leu Ser Glu Asp Lys  Cys Val Pro Arg Ser  Gln Cys Gly 
    2255                 2260                 2265             


Cys Lys  Asp Ala His Gly Gly  Ser Ile Pro Leu Gly  Lys Ser Trp 
    2270                 2275                 2280             


Val Ser  Ser Gly Cys Thr Glu  Lys Cys Val Cys Thr  Gly Gly Ala 
    2285                 2290                 2295             


Ile Gln  Cys Gly Asp Phe Arg  Cys Pro Ser Gly Ser  His Cys Gln 
    2300                 2305                 2310             


Leu Thr  Ser Asp Asn Ser Asn  Ser Asn Cys Val Ser  Asp Lys Ser 
    2315                 2320                 2325             


Glu Gln  Cys Ser Val Tyr Gly  Asp Pro Arg Tyr Leu  Thr Phe Asp 
    2330                 2335                 2340             


Gly Phe  Ser Tyr Arg Leu Gln  Gly Arg Met Thr Tyr  Val Leu Ile 
    2345                 2350                 2355             


Lys Thr  Val Asp Val Leu Pro  Glu Gly Val Glu Pro  Leu Leu Val 
    2360                 2365                 2370             


Glu Gly  Arg Asn Lys Met Asp  Pro Pro Arg Ser Ser  Ile Phe Leu 
    2375                 2380                 2385             


Gln Glu  Val Ile Thr Thr Val  Tyr Gly Tyr Lys Val  Gln Leu Gln 
    2390                 2395                 2400             


Ala Gly  Leu Glu Leu Val Val  Asn Asn Gln Lys Met  Ala Val Pro 
    2405                 2410                 2415             


Tyr Arg  Pro Asn Glu His Leu  Arg Val Thr Leu Trp  Gly Gln Arg 
    2420                 2425                 2430             


Leu Tyr  Leu Val Thr Asp Phe  Glu Leu Val Val Ser  Phe Gly Gly 
    2435                 2440                 2445             


Arg Lys  Asn Ala Val Ile Ser  Leu Pro Ser Met Tyr  Glu Gly Leu 
    2450                 2455                 2460             


Val Ser  Gly Leu Cys Gly Asn  Tyr Asp Lys Asn Arg  Lys Asn Asp 
    2465                 2470                 2475             


Met Met  Leu Pro Ser Gly Ala  Leu Thr Gln Asn Leu  Asn Thr Phe 
    2480                 2485                 2490             


Gly Asn  Ser Trp Glu Val Lys  Thr Glu Asp Ala Leu  Leu Arg Phe 
    2495                 2500                 2505             


Pro Arg  Ala Ile Pro Ala Glu  Glu Glu Gly Gln Gly  Ala Glu Leu 
    2510                 2515                 2520             


Gly Leu  Arg Thr Gly Leu Gln  Val Ser Glu Cys Ser  Pro Glu Gln 
    2525                 2530                 2535             


Leu Ala  Ser Asn Ser Thr Gln  Ala Cys Arg Val Leu  Ala Asp Pro 
    2540                 2545                 2550             


Gln Gly  Pro Phe Ala Ala Cys  His Gln Thr Val Ala  Pro Glu Pro 
    2555                 2560                 2565             


Phe Gln  Glu His Cys Val Leu  Asp Leu Cys Ser Ala  Gln Asp Pro 
    2570                 2575                 2580             


Arg Glu  Gln Glu Glu Leu Arg  Cys Gln Val Leu Ser  Gly Tyr Ala 
    2585                 2590                 2595             


Ile Leu  Cys Gln Glu Ala Gly  Ala Ala Leu Ala Gly  Trp Arg Asp 
    2600                 2605                 2610             


Arg Thr  Leu Cys Glu Ser Pro  Cys Leu Gln Asn Pro  Cys Gln Asn 
    2615                 2620                 2625             


Asp Gly  Gln Cys Arg Glu Gln  Gly Ala Thr Phe Thr  Cys Glu Cys 
    2630                 2635                 2640             


Glu Val  Gly Tyr Gly Gly Gly  Leu Cys Met Glu Pro  Arg Asp Ala 
    2645                 2650                 2655             


Pro Pro  Pro Arg Lys Pro Ala  Ser Asn Leu Val Gly  Val Leu Leu 
    2660                 2665                 2670             


Gly Leu  Leu Val Pro Val Val  Val Val Leu Leu Ala  Val Thr Arg 
    2675                 2680                 2685             


Glu Cys  Ile Tyr Arg Thr Arg  Arg Lys Arg Glu Lys  Thr Gln Glu 
    2690                 2695                 2700             


Gly Asp  Arg Leu Ala Arg Leu  Val Asp Thr Asp Thr  Val Leu Asp 
    2705                 2710                 2715             


Cys Ala  Cys 
    2720     


<210>  6328
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  6328

Met Ala Gly Pro Glu Arg Trp Gly Pro Leu Leu Leu Cys Leu Leu Gln 
1               5                   10                  15      


Ala Ala Pro Gly Arg Pro Arg Leu Ala Pro Pro Gln Asn Val Thr Leu 
            20                  25                  30          


Leu Ser Gln Asn Phe Ser Val Tyr Leu Thr Trp Leu Pro Gly Leu Gly 
        35                  40                  45              


Asn Pro Gln Asp Val Thr Tyr Phe Val Ala Tyr Gln Ser Ser Pro Thr 
    50                  55                  60                  


Arg Arg Arg Trp Arg Glu Val Glu Glu Cys Ala Gly Thr Lys Glu Leu 
65                  70                  75                  80  


Leu Cys Ser Met Met Cys Leu Lys Lys Gln Asp Leu Tyr Asn Lys Phe 
                85                  90                  95      


Lys Gly Arg Val Arg Thr Val Ser Pro Ser Ser Lys Ser Pro Trp Val 
            100                 105                 110         


Glu Ser Glu Tyr Leu Asp Tyr Leu Phe Glu Val Glu Pro Ala Pro Pro 
        115                 120                 125             


Val Leu Val Leu Thr Gln Thr Glu Glu Ile Leu Ser Ala Asn Ala Thr 
    130                 135                 140                 


Tyr Gln Leu Pro Pro Cys Met Pro Pro Leu Asp Leu Lys Tyr Glu Val 
145                 150                 155                 160 


Ala Phe Trp Lys Glu Gly Ala Gly Asn Lys Thr Leu Phe Pro Val Thr 
                165                 170                 175     


Pro His Gly Gln Pro Val Gln Ile Thr Leu Gln Pro Ala Ala Ser Glu 
            180                 185                 190         


His His Cys Leu Ser Ala Arg Thr Ile Tyr Thr Phe Ser Val Pro Lys 
        195                 200                 205             


Tyr Ser Lys Phe Ser Lys Pro Thr Cys Phe Leu Leu Glu Val Pro Glu 
    210                 215                 220                 


Ala Asn Trp Ala Phe Leu Val Leu Pro Ser Leu Leu Ile Leu Leu Leu 
225                 230                 235                 240 


Val Ile Ala Ala Gly Gly Val Ile Trp Lys Thr Leu Met Gly Asn Pro 
                245                 250                 255     


Trp Phe Gln Arg Ala Lys Met Pro Arg Ala Leu Glu Leu Thr Arg Gly 
            260                 265                 270         


Val Arg Pro Thr Pro Arg Val Arg Ala Pro Ala Thr Gln Gln Thr Arg 
        275                 280                 285             


Trp Lys Lys Asp Leu Ala Glu Asp Glu Glu Glu Glu Asp Glu Glu Asp 
    290                 295                 300                 


Thr Glu Asp Gly Val Ser Phe Gln Pro Tyr Ile Glu Pro Pro Ser Phe 
305                 310                 315                 320 


Leu Gly Gln Glu His Gln Ala Pro Gly His Ser Glu Ala Gly Gly Val 
                325                 330                 335     


Asp Ser Gly Arg Pro Arg Ala Pro Leu Val Pro Ser Glu Gly Ser Ser 
            340                 345                 350         


Ala Trp Asp Ser Ser Asp Arg Ser Trp Ala Ser Thr Val Asp Ser Ser 
        355                 360                 365             


Trp Asp Arg Ala Gly Ser Ser Gly Tyr Leu Ala Glu Lys Gly Pro Gly 
    370                 375                 380                 


Gln Gly Pro Gly Gly Asp Gly His Gln Glu Ser Leu Pro Pro Pro Glu 
385                 390                 395                 400 


Phe Ser Lys Asp Ser Gly Phe Leu Glu Glu Leu Pro Glu Asp Asn Leu 
                405                 410                 415     


Ser Ser Trp Ala Thr Trp Gly Thr Leu Pro Pro Glu Pro Asn Leu Val 
            420                 425                 430         


Pro Gly Gly Pro Pro Val Ser Leu Gln Thr Leu Thr Phe Cys Trp Glu 
        435                 440                 445             


Ser Ser Pro Glu Glu Glu Glu Glu Ala Arg Glu Ser Glu Ile Glu Asp 
    450                 455                 460                 


Ser Asp Ala Gly Ser Trp Gly Ala Glu Ser Thr Gln Arg Thr Glu Asp 
465                 470                 475                 480 


Arg Gly Arg Thr Leu Gly His Tyr Met Ala Arg 
                485                 490     


<210>  6329
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  6329

Met Ala Gly Pro Glu Arg Trp Gly Pro Leu Leu Leu Cys Leu Leu Gln 
1               5                   10                  15      


Ala Ala Pro Gly Arg Pro Arg Leu Ala Pro Pro Gln Asn Val Thr Leu 
            20                  25                  30          


Leu Ser Gln Asn Phe Ser Val Tyr Leu Thr Trp Leu Pro Gly Leu Gly 
        35                  40                  45              


Asn Pro Gln Asp Val Thr Tyr Phe Val Ala Tyr Gln Ser Ser Pro Thr 
    50                  55                  60                  


Arg Arg Arg Trp Arg Glu Val Glu Glu Cys Ala Gly Thr Lys Glu Leu 
65                  70                  75                  80  


Leu Cys Ser Met Met Cys Leu Lys Lys Gln Asp Leu Tyr Asn Lys Phe 
                85                  90                  95      


Lys Gly Arg Val Arg Thr Val Ser Pro Ser Ser Lys Ser Pro Trp Val 
            100                 105                 110         


Glu Ser Glu Tyr Leu Asp Tyr Leu Phe Glu Val Glu Pro Ala Pro Pro 
        115                 120                 125             


Val Leu Val Leu Thr Gln Thr Glu Glu Ile Leu Ser Ala Asn Ala Thr 
    130                 135                 140                 


Tyr Gln Leu Pro Pro Cys Met Pro Pro Leu Asp Leu Lys Tyr Glu Val 
145                 150                 155                 160 


Ala Phe Trp Lys Glu Gly Ala Gly Asn Lys Thr Leu Phe Pro Val Thr 
                165                 170                 175     


Pro His Gly Gln Pro Val Gln Ile Thr Leu Gln Pro Ala Ala Ser Glu 
            180                 185                 190         


His His Cys Leu Ser Ala Arg Thr Ile Tyr Thr Phe Ser Val Pro Lys 
        195                 200                 205             


Tyr Ser Lys Phe Ser Lys Pro Thr Cys Phe Leu Leu Glu Val Pro Gly 
    210                 215                 220                 


Leu Phe Trp Thr His Thr Pro Cys Gly Asn Leu Ser Ala Gln Gln Thr 
225                 230                 235                 240 


Arg Val Arg Glu 
                


<210>  6330
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  6330

Met Gly Arg Trp Ala Leu Asp Val Ala Phe Leu Trp Lys Ala Val Leu 
1               5                   10                  15      


Thr Leu Gly Leu Val Leu Leu Tyr Tyr Cys Phe Ser Ile Gly Ile Thr 
            20                  25                  30          


Phe Tyr Asn Lys Trp Leu Thr Lys Ser Phe His Phe Pro Leu Phe Met 
        35                  40                  45              


Thr Met Leu His Leu Ala Val Ile Phe Leu Phe Ser Ala Leu Ser Arg 
    50                  55                  60                  


Ala Leu Val Gln Cys Ser Ser His Arg Ala Arg Val Val Leu Ser Trp 
65                  70                  75                  80  


Ala Asp Tyr Leu Arg Arg Val Ala Pro Thr Ala Leu Ala Thr Ala Leu 
                85                  90                  95      


Asp Val Gly Leu Ser Asn Trp Ser Phe Leu Tyr Val Thr Val Ser Leu 
            100                 105                 110         


Tyr Thr Met Thr Lys Ser Ser Ala Val Leu Phe Ile Leu Ile Phe Ser 
        115                 120                 125             


Leu Ile Phe Lys Leu Glu Glu Leu Ser Thr Gln Phe Asn Val Glu Gly 
    130                 135                 140                 


Phe Ala Leu Val Leu Gly Ala Ser Phe Ile Gly Gly Ile Arg Trp Thr 
145                 150                 155                 160 


Leu Thr Gln Met Leu Leu Gln Lys Ala Glu Leu Gly Leu Gln Asn Pro 
                165                 170                 175     


Ile Asp Thr Met Phe His Leu Gln Pro Leu Met Phe Leu Gly Leu Phe 
            180                 185                 190         


Pro Leu Phe Ala Val Phe Glu Gly Leu His Leu Ser Thr Ser Glu Lys 
        195                 200                 205             


Ile Phe Arg Phe Gln Asp Thr Gly Leu Leu Leu Arg Val Leu Gly Ser 
    210                 215                 220                 


Leu Phe Leu Gly Gly Ile Leu Ala Phe Gly Leu Gly Phe Ser Glu Phe 
225                 230                 235                 240 


Leu Leu Val Ser Arg Thr Ser Ser Leu Thr Leu Ser Ile Ala Gly Ile 
                245                 250                 255     


Phe Lys Glu Val Cys Thr Leu Leu Leu Ala Ala His Leu Leu Gly Asp 
            260                 265                 270         


Gln Ile Ser Leu Leu Asn Trp Leu Gly Phe Ala Leu Cys Leu Ser Gly 
        275                 280                 285             


Ile Ser Leu His Val Ala Leu Lys Ala Leu His Ser Arg Gly Asp Gly 
    290                 295                 300                 


Gly Pro Lys Ala Leu Lys Gly Leu Gly Ser Ser Pro Asp Leu Glu Leu 
305                 310                 315                 320 


Leu Leu Arg Ser Ser Gln Arg Glu Glu Gly Asp Asn Glu Glu Glu Glu 
                325                 330                 335     


Tyr Phe Val Ala Gln Gly Gln Gln 
            340                 


<210>  6331
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  6331

Met Lys Asp Asn Asp Ile Lys Arg Leu Leu Tyr Thr His Leu Leu Cys 
1               5                   10                  15      


Ile Phe Ser Ile Ile Leu Ser Val Phe Ile Pro Ser Leu Phe Leu Glu 
            20                  25                  30          


Asn Phe Ser Ile Leu Glu Thr His Leu Thr Trp Leu Cys Ile Cys Ser 
        35                  40                  45              


Gly Phe Val Thr Ala Val Asn Leu Val Leu Tyr Leu Val Val Lys Pro 
    50                  55                  60                  


Asn Thr Ser Ser Lys Arg Ser Ser Leu Ser His Lys Val Thr Gly Phe 
65                  70                  75                  80  


Leu Lys Cys Cys Ile Tyr Phe Leu Met Ser Cys Phe Ser Phe His Val 
                85                  90                  95      


Ile Phe Val Leu Tyr Gly Ala Pro Leu Ile Glu Leu Ala Leu Glu Thr 
            100                 105                 110         


Phe Leu Phe Ala Val Ile Leu Ser Thr Phe Thr Thr Val Pro Cys Leu 
        115                 120                 125             


Cys Leu Leu Gly Pro Asn Leu Lys Ala Trp Leu Arg Val Phe Ser Arg 
    130                 135                 140                 


Asn Gly Val Thr Ser Ile Trp Glu Asn Ser Leu Gln Ile Thr Thr Ile 
145                 150                 155                 160 


Ser Ser Phe Val Gly Ala Trp Leu Gly Ala Leu Pro Ile Pro Leu Asp 
                165                 170                 175     


Trp Glu Arg Pro Trp Gln Met Thr Val Glu Arg Lys Arg Ser Thr Tyr 
            180                 185                 190         


Arg Ser Leu His Val Pro Cys Arg Gly Leu Gly Thr Val Lys 
        195                 200                 205     


<210>  6332
<211>  2595
<212>  PRT
<213>  Homo sapiens

<400>  6332

Met Ala Ser Leu Phe His Gln Leu Gln Ile Leu Val Trp Lys Asn Trp 
1               5                   10                  15      


Leu Gly Val Lys Arg Gln Pro Leu Trp Thr Leu Val Leu Ile Leu Trp 
            20                  25                  30          


Pro Val Ile Ile Phe Ile Ile Leu Ala Ile Thr Arg Thr Lys Phe Pro 
        35                  40                  45              


Pro Thr Ala Lys Pro Thr Cys Tyr Leu Ala Pro Arg Asn Leu Pro Ser 
    50                  55                  60                  


Thr Gly Phe Phe Pro Phe Leu Gln Thr Leu Leu Cys Asp Thr Asp Ser 
65                  70                  75                  80  


Lys Cys Lys Asp Thr Pro Tyr Gly Pro Gln Asp Leu Leu Arg Arg Lys 
                85                  90                  95      


Gly Ile Asp Asp Ala Leu Phe Lys Asp Ser Glu Ile Leu Arg Lys Ser 
            100                 105                 110         


Ser Asn Leu Asp Lys Asp Ser Ser Leu Ser Phe Gln Ser Thr Gln Val 
        115                 120                 125             


Pro Glu Arg Arg His Ala Ser Leu Ala Thr Val Phe Pro Ser Pro Ser 
    130                 135                 140                 


Ser Asp Leu Glu Ile Pro Gly Thr Tyr Thr Phe Asn Gly Ser Gln Val 
145                 150                 155                 160 


Leu Ala Arg Ile Leu Gly Leu Glu Lys Leu Leu Lys Gln Asn Ser Thr 
                165                 170                 175     


Ser Glu Asp Ile Arg Arg Glu Leu Cys Asp Ser Tyr Ser Gly Tyr Ile 
            180                 185                 190         


Val Asp Asp Ala Phe Ser Trp Thr Phe Leu Gly Arg Asn Val Phe Asn 
        195                 200                 205             


Lys Phe Cys Leu Ser Asn Met Thr Leu Leu Glu Ser Ser Leu Gln Glu 
    210                 215                 220                 


Leu Asn Lys Gln Phe Ser Gln Leu Ser Ser Asp Pro Asn Asn Gln Lys 
225                 230                 235                 240 


Ile Val Phe Gln Glu Ile Val Arg Met Leu Ser Phe Phe Ser Gln Val 
                245                 250                 255     


Gln Glu Gln Lys Ala Val Trp Gln Leu Leu Ser Ser Phe Pro Asn Val 
            260                 265                 270         


Phe Gln Asn Asp Thr Ser Leu Ser Asn Leu Phe Asp Val Leu Arg Lys 
        275                 280                 285             


Ala Asn Ser Val Leu Leu Val Val Gln Lys Val Tyr Pro Arg Phe Ala 
    290                 295                 300                 


Thr Asn Glu Gly Phe Arg Thr Leu Gln Lys Ser Val Lys His Leu Leu 
305                 310                 315                 320 


Tyr Thr Leu Asp Ser Pro Ala Gln Gly Asp Ser Asp Asn Ile Thr His 
                325                 330                 335     


Val Trp Asn Glu Asp Asp Gly Gln Thr Leu Ser Pro Ser Ser Leu Ala 
            340                 345                 350         


Ala Gln Leu Leu Ile Leu Glu Asn Phe Glu Asp Ala Leu Leu Asn Ile 
        355                 360                 365             


Ser Ala Asn Ser Pro Tyr Ile Pro Tyr Leu Ala Cys Val Arg Asn Val 
    370                 375                 380                 


Thr Asp Ser Leu Ala Arg Gly Ser Pro Glu Asn Leu Arg Leu Leu Gln 
385                 390                 395                 400 


Ser Thr Ile Arg Phe Lys Lys Ser Phe Leu Arg Asn Gly Ser Tyr Glu 
                405                 410                 415     


Asp Tyr Phe Pro Pro Val Pro Glu Val Leu Lys Ser Lys Leu Ser Gln 
            420                 425                 430         


Leu Arg Asn Leu Thr Glu Leu Leu Cys Glu Ser Glu Thr Phe Ser Leu 
        435                 440                 445             


Ile Glu Lys Ser Cys Gln Leu Ser Asp Met Ser Phe Gly Ser Leu Cys 
    450                 455                 460                 


Glu Glu Ser Glu Phe Asp Leu Gln Leu Leu Glu Ala Ala Glu Leu Gly 
465                 470                 475                 480 


Thr Glu Ile Ala Ala Ser Leu Leu Tyr His Asp Asn Val Ile Ser Lys 
                485                 490                 495     


Lys Val Arg Asp Leu Leu Thr Gly Asp Pro Ser Lys Ile Asn Leu Asn 
            500                 505                 510         


Met Asp Gln Phe Leu Glu Gln Ala Leu Gln Met Asn Tyr Leu Glu Asn 
        515                 520                 525             


Ile Thr Gln Leu Ile Pro Ile Ile Glu Ala Met Leu His Val Asn Asn 
    530                 535                 540                 


Ser Ala Asp Ala Ser Glu Lys Pro Gly Gln Leu Leu Glu Met Phe Lys 
545                 550                 555                 560 


Asn Val Glu Glu Leu Lys Glu Asp Leu Arg Arg Thr Thr Gly Met Ser 
                565                 570                 575     


Asn Arg Thr Ile Asp Lys Leu Leu Ala Ile Pro Ile Pro Asp Asn Arg 
            580                 585                 590         


Ala Glu Ile Ile Ser Gln Val Phe Trp Leu His Ser Cys Asp Thr Asn 
        595                 600                 605             


Ile Thr Thr Pro Lys Leu Glu Asp Ala Met Lys Glu Phe Cys Asn Leu 
    610                 615                 620                 


Ser Leu Ser Glu Arg Ser Arg Gln Ser Tyr Leu Ile Gly Leu Thr Leu 
625                 630                 635                 640 


Leu His Tyr Leu Asn Ile Tyr Asn Phe Thr Tyr Lys Val Phe Phe Pro 
                645                 650                 655     


Arg Lys Asp Gln Lys Pro Val Glu Lys Met Met Glu Leu Phe Ile Arg 
            660                 665                 670         


Leu Lys Glu Ile Leu Asn Gln Met Ala Ser Gly Thr His Pro Leu Leu 
        675                 680                 685             


Asp Lys Met Arg Ser Leu Lys Gln Met His Leu Pro Arg Ser Val Pro 
    690                 695                 700                 


Leu Thr Gln Ala Met Tyr Arg Ser Asn Arg Met Asn Thr Pro Gln Gly 
705                 710                 715                 720 


Ser Phe Ser Thr Ile Ser Gln Ala Leu Cys Ser Gln Gly Ile Thr Thr 
                725                 730                 735     


Glu Tyr Leu Thr Ala Met Leu Pro Ser Ser Gln Arg Pro Lys Gly Asn 
            740                 745                 750         


His Thr Lys Asp Phe Leu Thr Tyr Lys Leu Thr Lys Glu Gln Ile Ala 
        755                 760                 765             


Ser Lys Tyr Gly Ile Pro Ile Asn Ser Thr Pro Phe Cys Phe Ser Leu 
    770                 775                 780                 


Tyr Lys Asp Ile Ile Asn Met Pro Ala Gly Pro Val Ile Trp Ala Phe 
785                 790                 795                 800 


Leu Lys Pro Met Leu Leu Gly Arg Ile Leu Tyr Ala Pro Tyr Asn Pro 
                805                 810                 815     


Val Thr Lys Ala Ile Met Glu Lys Ser Asn Val Thr Leu Arg Gln Leu 
            820                 825                 830         


Ala Glu Leu Arg Glu Lys Ser Gln Glu Trp Met Asp Lys Ser Pro Leu 
        835                 840                 845             


Phe Met Asn Ser Phe His Leu Leu Asn Gln Ala Ile Pro Met Leu Gln 
    850                 855                 860                 


Asn Thr Leu Arg Asn Pro Phe Val Gln Val Phe Val Lys Phe Ser Val 
865                 870                 875                 880 


Gly Leu Asp Ala Val Glu Leu Leu Lys Gln Ile Asp Glu Leu Asp Ile 
                885                 890                 895     


Leu Arg Leu Lys Leu Glu Asn Asn Ile Asp Ile Ile Asp Gln Leu Asn 
            900                 905                 910         


Thr Leu Ser Ser Leu Thr Val Asn Ile Ser Ser Cys Val Leu Tyr Asp 
        915                 920                 925             


Arg Ile Gln Ala Ala Lys Thr Ile Asp Glu Met Glu Arg Glu Ala Lys 
    930                 935                 940                 


Arg Leu Tyr Lys Ser Asn Glu Leu Phe Gly Ser Val Ile Phe Lys Leu 
945                 950                 955                 960 


Pro Ser Asn Arg Ser Trp His Arg Gly Tyr Asp Ser Gly Asn Val Phe 
                965                 970                 975     


Leu Pro Pro Val Ile Lys Tyr Thr Ile Arg Met Ser Leu Lys Thr Ala 
            980                 985                 990         


Gln Thr Thr Arg Ser Leu Arg Thr  Lys Ile Trp Ala Pro  Gly Pro His 
        995                 1000                 1005             


Asn Ser  Pro Ser His Asn Gln  Ile Tyr Gly Arg Ala  Phe Ile Tyr 
    1010                 1015                 1020             


Leu Gln  Asp Ser Ile Glu Arg  Ala Ile Ile Glu Leu  Gln Thr Gly 
    1025                 1030                 1035             


Arg Asn  Ser Gln Glu Ile Ala  Val Gln Val Gln Ala  Ile Pro Tyr 
    1040                 1045                 1050             


Pro Cys  Phe Met Lys Asp Asn  Phe Leu Thr Ser Val  Ser Tyr Ser 
    1055                 1060                 1065             


Leu Pro  Ile Val Leu Met Val  Ala Trp Val Val Phe  Ile Ala Ala 
    1070                 1075                 1080             


Phe Val  Lys Lys Leu Val Tyr  Glu Lys Asp Leu Arg  Leu His Glu 
    1085                 1090                 1095             


Tyr Met  Lys Met Met Gly Val  Asn Ser Cys Ser His  Phe Phe Ala 
    1100                 1105                 1110             


Trp Leu  Ile Glu Ser Val Gly  Phe Leu Leu Val Thr  Ile Val Ile 
    1115                 1120                 1125             


Leu Ile  Ile Ile Leu Lys Phe  Gly Asn Ile Leu Pro  Lys Thr Asn 
    1130                 1135                 1140             


Gly Phe  Ile Leu Phe Leu Tyr  Phe Ser Asp Tyr Ser  Phe Ser Val 
    1145                 1150                 1155             


Ile Ala  Met Ser Tyr Leu Ile  Ser Val Phe Phe Asn  Asn Thr Asn 
    1160                 1165                 1170             


Ile Ala  Ala Leu Ile Gly Ser  Leu Ile Tyr Ile Ile  Ala Phe Phe 
    1175                 1180                 1185             


Pro Phe  Ile Val Leu Val Thr  Val Glu Asn Glu Leu  Ser Tyr Val 
    1190                 1195                 1200             


Leu Lys  Val Phe Met Ser Leu  Leu Ser Pro Thr Ala  Phe Ser Tyr 
    1205                 1210                 1215             


Ala Ser  Gln Tyr Ile Ala Arg  Tyr Glu Glu Gln Gly  Ile Gly Leu 
    1220                 1225                 1230             


Gln Trp  Glu Asn Met Tyr Thr  Ser Pro Val Gln Asp  Asp Thr Thr 
    1235                 1240                 1245             


Ser Phe  Gly Trp Leu Cys Cys  Leu Ile Leu Ala Asp  Ser Phe Ile 
    1250                 1255                 1260             


Tyr Phe  Leu Ile Ala Trp Tyr  Val Arg Asn Val Phe  Pro Gly Thr 
    1265                 1270                 1275             


Tyr Gly  Met Ala Ala Pro Trp  Tyr Phe Pro Ile Leu  Pro Ser Tyr 
    1280                 1285                 1290             


Trp Lys  Glu Arg Phe Gly Cys  Ala Glu Val Lys Pro  Glu Lys Ser 
    1295                 1300                 1305             


Asn Gly  Leu Met Phe Thr Asn  Ile Met Met Gln Asn  Thr Asn Pro 
    1310                 1315                 1320             


Ser Ala  Ser Pro Glu Tyr Met  Phe Ser Ser Asn Ile  Glu Pro Glu 
    1325                 1330                 1335             


Pro Lys  Asp Leu Thr Val Gly  Val Ala Leu His Gly  Val Thr Lys 
    1340                 1345                 1350             


Ile Tyr  Gly Ser Lys Val Ala  Val Asp Asn Leu Asn  Leu Asn Phe 
    1355                 1360                 1365             


Tyr Glu  Gly His Ile Thr Ser  Leu Leu Gly Pro Asn  Gly Ala Gly 
    1370                 1375                 1380             


Lys Thr  Thr Thr Ile Ser Met  Leu Thr Gly Leu Phe  Gly Ala Ser 
    1385                 1390                 1395             


Ala Gly  Thr Ile Phe Val Tyr  Gly Lys Asp Ile Lys  Thr Asp Leu 
    1400                 1405                 1410             


His Thr  Val Arg Lys Asn Met  Gly Val Cys Met Gln  His Asp Val 
    1415                 1420                 1425             


Leu Phe  Ser Tyr Leu Thr Thr  Lys Glu His Leu Leu  Leu Tyr Gly 
    1430                 1435                 1440             


Ser Ile  Lys Val Pro His Trp  Thr Lys Lys Gln Leu  His Glu Glu 
    1445                 1450                 1455             


Val Lys  Arg Thr Leu Lys Asp  Thr Gly Leu Tyr Ser  His Arg His 
    1460                 1465                 1470             


Lys Arg  Val Gly Thr Leu Ser  Gly Gly Met Lys Arg  Lys Leu Ser 
    1475                 1480                 1485             


Ile Ser  Ile Ala Leu Ile Gly  Gly Ser Arg Val Val  Ile Leu Asp 
    1490                 1495                 1500             


Glu Pro  Ser Thr Gly Val Asp  Pro Cys Ser Arg Arg  Ser Ile Trp 
    1505                 1510                 1515             


Asp Val  Ile Ser Lys Asn Lys  Thr Ala Arg Thr Ile  Ile Leu Ser 
    1520                 1525                 1530             


Thr His  His Leu Asp Glu Ala  Glu Val Leu Ser Asp  Arg Ile Ala 
    1535                 1540                 1545             


Phe Leu  Glu Gln Gly Gly Leu  Arg Cys Cys Gly Ser  Pro Phe Tyr 
    1550                 1555                 1560             


Leu Lys  Glu Ala Phe Gly Asp  Gly Tyr His Leu Thr  Leu Thr Lys 
    1565                 1570                 1575             


Lys Lys  Ser Pro Asn Leu Asn  Ala Asn Ala Val Cys  Asp Thr Met 
    1580                 1585                 1590             


Ala Val  Thr Ala Met Ile Gln  Ser His Leu Pro Glu  Ala Tyr Leu 
    1595                 1600                 1605             


Lys Glu  Asp Ile Gly Gly Glu  Leu Val Tyr Val Leu  Pro Pro Phe 
    1610                 1615                 1620             


Ser Thr  Lys Val Ser Gly Ala  Tyr Leu Ser Leu Leu  Arg Ala Leu 
    1625                 1630                 1635             


Asp Asn  Gly Met Gly Asp Leu  Asn Ile Gly Cys Tyr  Gly Ile Ser 
    1640                 1645                 1650             


Asp Thr  Thr Val Glu Glu Val  Phe Leu Asn Leu Thr  Lys Glu Ser 
    1655                 1660                 1665             


Gln Lys  Asn Ser Ala Met Ser  Leu Glu His Leu Thr  Gln Lys Lys 
    1670                 1675                 1680             


Ile Gly  Asn Ser Asn Ala Asn  Gly Ile Ser Thr Pro  Asp Asp Leu 
    1685                 1690                 1695             


Ser Val  Ser Ser Ser Asn Phe  Thr Asp Arg Asp Asp  Lys Ile Leu 
    1700                 1705                 1710             


Thr Arg  Gly Glu Arg Leu Asp  Gly Phe Gly Leu Leu  Leu Lys Lys 
    1715                 1720                 1725             


Ile Met  Ala Ile Leu Ile Lys  Arg Phe His His Thr  Arg Arg Asn 
    1730                 1735                 1740             


Trp Lys  Gly Leu Ile Ala Gln  Val Ile Leu Pro Ile  Val Phe Val 
    1745                 1750                 1755             


Thr Thr  Ala Met Gly Leu Gly  Thr Leu Arg Asn Ser  Ser Asn Ser 
    1760                 1765                 1770             


Tyr Pro  Glu Ile Gln Ile Ser  Pro Ser Leu Tyr Gly  Thr Ser Glu 
    1775                 1780                 1785             


Gln Thr  Ala Phe Tyr Ala Asn  Tyr His Pro Ser Thr  Glu Ala Leu 
    1790                 1795                 1800             


Val Ser  Ala Met Trp Asp Phe  Pro Gly Ile Asp Asn  Met Cys Leu 
    1805                 1810                 1815             


Asn Thr  Ser Asp Leu Gln Cys  Leu Asn Lys Asp Ser  Leu Glu Lys 
    1820                 1825                 1830             


Trp Asn  Thr Ser Gly Glu Pro  Ile Thr Asn Phe Gly  Val Cys Ser 
    1835                 1840                 1845             


Cys Ser  Glu Asn Val Gln Glu  Cys Pro Lys Phe Asn  Tyr Ser Pro 
    1850                 1855                 1860             


Pro His  Arg Arg Thr Tyr Ser  Ser Gln Val Ile Tyr  Asn Leu Thr 
    1865                 1870                 1875             


Gly Gln  Arg Val Glu Asn Tyr  Leu Ile Ser Thr Ala  Asn Glu Phe 
    1880                 1885                 1890             


Val Gln  Lys Arg Tyr Gly Gly  Trp Ser Phe Gly Leu  Pro Leu Thr 
    1895                 1900                 1905             


Lys Asp  Leu Arg Phe Asp Ile  Thr Gly Val Pro Ala  Asn Arg Thr 
    1910                 1915                 1920             


Leu Ala  Lys Val Trp Tyr Asp  Pro Glu Gly Tyr His  Ser Leu Pro 
    1925                 1930                 1935             


Ala Tyr  Leu Asn Ser Leu Asn  Asn Phe Leu Leu Arg  Val Asn Met 
    1940                 1945                 1950             


Ser Lys  Tyr Asp Ala Ala Arg  His Gly Ile Ile Met  Tyr Ser His 
    1955                 1960                 1965             


Pro Tyr  Pro Gly Val Gln Asp  Gln Glu Gln Ala Thr  Ile Ser Ser 
    1970                 1975                 1980             


Leu Ile  Asp Ile Leu Val Ala  Leu Ser Ile Leu Met  Gly Tyr Ser 
    1985                 1990                 1995             


Val Thr  Thr Ala Ser Phe Val  Thr Tyr Val Val Arg  Glu His Gln 
    2000                 2005                 2010             


Thr Lys  Ala Lys Gln Leu Gln  His Ile Ser Gly Ile  Gly Val Thr 
    2015                 2020                 2025             


Cys Tyr  Trp Val Thr Asn Phe  Ile Tyr Asp Met Val  Phe Tyr Leu 
    2030                 2035                 2040             


Val Pro  Val Ala Phe Ser Ile  Gly Ile Ile Ala Ile  Phe Lys Leu 
    2045                 2050                 2055             


Pro Ala  Phe Tyr Ser Glu Asn  Asn Leu Gly Ala Val  Ser Leu Leu 
    2060                 2065                 2070             


Leu Leu  Leu Phe Gly Tyr Ala  Thr Phe Ser Trp Met  Tyr Leu Leu 
    2075                 2080                 2085             


Ala Gly  Leu Phe His Glu Thr  Gly Met Ala Phe Ile  Thr Tyr Val 
    2090                 2095                 2100             


Cys Val  Asn Leu Phe Phe Gly  Ile Asn Ser Ile Val  Ser Leu Ser 
    2105                 2110                 2115             


Val Val  Tyr Phe Leu Ser Lys  Glu Lys Pro Asn Asp  Pro Thr Leu 
    2120                 2125                 2130             


Glu Leu  Ile Ser Glu Thr Leu  Lys Arg Ile Phe Leu  Ile Phe Pro 
    2135                 2140                 2145             


Gln Phe  Cys Phe Gly Tyr Gly  Leu Ile Glu Leu Ser  Gln Gln Gln 
    2150                 2155                 2160             


Ser Val  Leu Asp Phe Leu Lys  Ala Tyr Gly Val Glu  Tyr Pro Asn 
    2165                 2170                 2175             


Glu Thr  Phe Glu Met Asn Lys  Leu Gly Ala Met Phe  Val Ala Leu 
    2180                 2185                 2190             


Val Ser  Gln Gly Thr Met Phe  Phe Ser Leu Arg Leu  Leu Ile Asn 
    2195                 2200                 2205             


Glu Ser  Leu Ile Lys Lys Leu  Arg Leu Phe Phe Arg  Lys Phe Asn 
    2210                 2215                 2220             


Ser Ser  His Val Arg Glu Thr  Ile Asp Glu Asp Glu  Asp Val Arg 
    2225                 2230                 2235             


Ala Glu  Arg Leu Arg Val Glu  Ser Gly Ala Ala Glu  Phe Asp Leu 
    2240                 2245                 2250             


Val Gln  Leu Tyr Cys Leu Thr  Lys Thr Tyr Gln Leu  Ile His Lys 
    2255                 2260                 2265             


Lys Ile  Ile Ala Val Asn Asn  Ile Ser Ile Gly Ile  Pro Ala Gly 
    2270                 2275                 2280             


Glu Cys  Phe Gly Leu Leu Gly  Val Asn Gly Ala Gly  Lys Thr Thr 
    2285                 2290                 2295             


Ile Phe  Lys Met Leu Thr Gly  Asp Ile Ile Pro Ser  Ser Gly Asn 
    2300                 2305                 2310             


Ile Leu  Ile Arg Asn Lys Thr  Gly Ser Leu Gly His  Val Asp Ser 
    2315                 2320                 2325             


His Ser  Ser Leu Val Gly Tyr  Cys Pro Gln Glu Asp  Ala Leu Asp 
    2330                 2335                 2340             


Asp Leu  Val Thr Val Glu Glu  His Leu Tyr Phe Tyr  Ala Arg Val 
    2345                 2350                 2355             


His Gly  Ile Pro Glu Lys Asp  Ile Lys Glu Thr Val  His Lys Leu 
    2360                 2365                 2370             


Leu Arg  Arg Leu His Leu Met  Pro Phe Lys Asp Arg  Ala Thr Ser 
    2375                 2380                 2385             


Met Cys  Ser Tyr Gly Thr Lys  Arg Lys Leu Ser Thr  Ala Leu Ala 
    2390                 2395                 2400             


Leu Ile  Gly Lys Pro Ser Ile  Leu Leu Leu Asp Glu  Pro Ser Ser 
    2405                 2410                 2415             


Gly Met  Asp Pro Lys Ser Lys  Arg His Leu Trp Lys  Ile Ile Ser 
    2420                 2425                 2430             


Glu Glu  Val Gln Asn Lys Cys  Ser Val Ile Leu Thr  Ser His Ser 
    2435                 2440                 2445             


Met Glu  Glu Cys Glu Ala Leu  Cys Thr Arg Leu Ala  Ile Met Val 
    2450                 2455                 2460             


Asn Gly  Lys Phe Gln Cys Ile  Gly Ser Leu Gln His  Ile Lys Ser 
    2465                 2470                 2475             


Arg Phe  Gly Arg Gly Phe Thr  Val Lys Val His Leu  Lys Asn Asn 
    2480                 2485                 2490             


Lys Val  Thr Met Glu Thr Leu  Thr Lys Phe Met Gln  Leu His Phe 
    2495                 2500                 2505             


Pro Lys  Thr Tyr Leu Lys Asp  Gln His Leu Ser Met  Leu Glu Tyr 
    2510                 2515                 2520             


His Val  Pro Val Thr Ala Gly  Gly Val Ala Asn Ile  Phe Asp Leu 
    2525                 2530                 2535             


Leu Glu  Thr Asn Lys Thr Ala  Leu Asn Ile Thr Asn  Phe Leu Val 
    2540                 2545                 2550             


Ser Gln  Thr Thr Leu Glu Glu  Val Phe Ile Asn Phe  Ala Lys Asp 
    2555                 2560                 2565             


Gln Lys  Ser Tyr Glu Thr Ala  Asp Thr Ser Ser Gln  Gly Ser Thr 
    2570                 2575                 2580             


Ile Ser  Val Asp Ser Gln Asp  Asp Gln Met Glu Ser  
    2585                 2590                 2595 


<210>  6333
<211>  837
<212>  PRT
<213>  Homo sapiens

<400>  6333

Met Phe Leu Trp Leu Phe Leu Ile Leu Ser Ala Leu Ile Ser Ser Thr 
1               5                   10                  15      


Asn Ala Asp Ser Asp Ile Ser Val Glu Ile Cys Asn Val Cys Ser Cys 
            20                  25                  30          


Val Ser Val Glu Asn Val Leu Tyr Val Asn Cys Glu Lys Val Ser Val 
        35                  40                  45              


Tyr Arg Pro Asn Gln Leu Lys Pro Pro Trp Ser Asn Phe Tyr His Leu 
    50                  55                  60                  


Asn Phe Gln Asn Asn Phe Leu Asn Ile Leu Tyr Pro Asn Thr Phe Leu 
65                  70                  75                  80  


Asn Phe Ser His Ala Val Ser Leu His Leu Gly Asn Asn Lys Leu Gln 
                85                  90                  95      


Asn Ile Glu Gly Gly Ala Phe Leu Gly Leu Ser Ala Leu Lys Gln Leu 
            100                 105                 110         


His Leu Asn Asn Asn Glu Leu Lys Ile Leu Arg Ala Asp Thr Phe Leu 
        115                 120                 125             


Gly Ile Glu Asn Leu Glu Tyr Leu Gln Ala Asp Tyr Asn Leu Ile Lys 
    130                 135                 140                 


Tyr Ile Glu Arg Gly Ala Phe Asn Lys Leu His Lys Leu Lys Val Leu 
145                 150                 155                 160 


Ile Leu Asn Asp Asn Leu Ile Ser Phe Leu Pro Asp Asn Ile Phe Arg 
                165                 170                 175     


Phe Ala Ser Leu Thr His Leu Asp Ile Arg Gly Asn Arg Ile Gln Lys 
            180                 185                 190         


Leu Pro Tyr Ile Gly Val Leu Glu His Ile Gly Arg Val Val Glu Leu 
        195                 200                 205             


Gln Leu Glu Asp Asn Pro Trp Asn Cys Ser Cys Asp Leu Leu Pro Leu 
    210                 215                 220                 


Lys Ala Trp Leu Glu Asn Met Pro Tyr Asn Ile Tyr Ile Gly Glu Ala 
225                 230                 235                 240 


Ile Cys Glu Thr Pro Ser Asp Leu Tyr Gly Arg Leu Leu Lys Glu Thr 
                245                 250                 255     


Asn Lys Gln Glu Leu Cys Pro Met Gly Thr Gly Ser Asp Phe Asp Val 
            260                 265                 270         


Arg Ile Leu Pro Pro Ser Gln Leu Glu Asn Gly Tyr Thr Thr Pro Asn 
        275                 280                 285             


Gly His Thr Thr Gln Thr Ser Leu His Arg Leu Val Thr Lys Pro Pro 
    290                 295                 300                 


Lys Thr Thr Asn Pro Ser Lys Ile Ser Gly Ile Val Ala Gly Lys Ala 
305                 310                 315                 320 


Leu Ser Asn Arg Asn Leu Ser Gln Ile Val Ser Tyr Gln Thr Arg Val 
                325                 330                 335     


Pro Pro Leu Thr Pro Cys Pro Ala Pro Cys Phe Cys Lys Thr His Pro 
            340                 345                 350         


Ser Asp Leu Gly Leu Ser Val Asn Cys Gln Glu Lys Asn Ile Gln Ser 
        355                 360                 365             


Met Ser Glu Leu Ile Pro Lys Pro Leu Asn Ala Lys Lys Leu His Val 
    370                 375                 380                 


Asn Gly Asn Ser Ile Lys Asp Val Asp Val Ser Asp Phe Thr Asp Phe 
385                 390                 395                 400 


Glu Gly Leu Asp Leu Leu His Leu Gly Ser Asn Gln Ile Thr Val Ile 
                405                 410                 415     


Lys Gly Asp Val Phe His Asn Leu Thr Asn Leu Arg Arg Leu Tyr Leu 
            420                 425                 430         


Asn Gly Asn Gln Ile Glu Arg Leu Tyr Pro Glu Ile Phe Ser Gly Leu 
        435                 440                 445             


His Asn Leu Gln Tyr Leu Tyr Leu Glu Tyr Asn Leu Ile Lys Glu Ile 
    450                 455                 460                 


Ser Ala Gly Thr Phe Asp Ser Met Pro Asn Leu Gln Leu Leu Tyr Leu 
465                 470                 475                 480 


Asn Asn Asn Leu Leu Lys Ser Leu Pro Val Tyr Ile Phe Ser Gly Ala 
                485                 490                 495     


Pro Leu Ala Arg Leu Asn Leu Arg Asn Asn Lys Phe Met Tyr Leu Pro 
            500                 505                 510         


Val Ser Gly Val Leu Asp Gln Leu Gln Ser Leu Thr Gln Ile Asp Leu 
        515                 520                 525             


Glu Gly Asn Pro Trp Asp Cys Thr Cys Asp Leu Val Ala Leu Lys Leu 
    530                 535                 540                 


Trp Val Glu Lys Leu Ser Asp Gly Ile Val Val Lys Glu Leu Lys Cys 
545                 550                 555                 560 


Glu Thr Pro Val Gln Phe Ala Asn Ile Glu Leu Lys Ser Leu Lys Asn 
                565                 570                 575     


Glu Ile Leu Cys Pro Lys Leu Leu Asn Lys Pro Ser Ala Pro Phe Thr 
            580                 585                 590         


Ser Pro Ala Pro Ala Ile Thr Phe Thr Thr Pro Leu Gly Pro Ile Arg 
        595                 600                 605             


Ser Pro Pro Gly Gly Pro Val Pro Leu Ser Ile Leu Ile Leu Ser Ile 
    610                 615                 620                 


Leu Val Val Leu Ile Leu Thr Val Phe Val Ala Phe Cys Leu Leu Val 
625                 630                 635                 640 


Phe Val Leu Arg Arg Asn Lys Lys Pro Thr Val Lys His Glu Gly Leu 
                645                 650                 655     


Gly Asn Pro Asp Cys Gly Ser Met Gln Leu Gln Leu Arg Lys His Asp 
            660                 665                 670         


His Lys Thr Asn Lys Lys Asp Gly Leu Ser Thr Glu Ala Phe Ile Pro 
        675                 680                 685             


Gln Thr Ile Glu Gln Met Ser Lys Ser His Thr Cys Gly Leu Lys Glu 
    690                 695                 700                 


Ser Glu Thr Gly Phe Met Phe Ser Asp Pro Pro Gly Gln Lys Val Val 
705                 710                 715                 720 


Met Arg Asn Val Ala Asp Lys Glu Lys Asp Leu Leu His Val Asp Thr 
                725                 730                 735     


Arg Lys Arg Leu Ser Thr Ile Asp Glu Leu Asp Glu Leu Phe Pro Ser 
            740                 745                 750         


Arg Asp Ser Asn Val Phe Ile Gln Asn Phe Leu Glu Ser Lys Lys Glu 
        755                 760                 765             


Tyr Asn Ser Ile Gly Val Ser Gly Phe Glu Ile Arg Tyr Pro Glu Lys 
    770                 775                 780                 


Gln Pro Asp Lys Lys Ser Lys Lys Ser Leu Ile Gly Gly Asn His Ser 
785                 790                 795                 800 


Lys Ile Val Val Glu Gln Arg Lys Ser Glu Tyr Phe Glu Leu Lys Ala 
                805                 810                 815     


Lys Leu Gln Ser Ser Pro Asp Tyr Leu Gln Val Leu Glu Glu Gln Thr 
            820                 825                 830         


Ala Leu Asn Lys Ile 
        835         


<210>  6334
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  6334

Met His Asn Phe Glu Glu Glu Leu Thr Cys Pro Ile Cys Tyr Ser Ile 
1               5                   10                  15      


Phe Glu Asp Pro Arg Val Leu Pro Cys Ser His Thr Phe Cys Arg Asn 
            20                  25                  30          


Cys Leu Glu Asn Ile Leu Gln Ala Ser Gly Asn Phe Tyr Ile Trp Arg 
        35                  40                  45              


Pro Leu Arg Ile Pro Leu Lys Cys Pro Asn Cys Arg Ser Ile Thr Glu 
    50                  55                  60                  


Ile Ala Pro Thr Gly Ile Glu Ser Leu Pro Val Asn Phe Ala Leu Arg 
65                  70                  75                  80  


Ala Ile Ile Glu Lys Tyr Gln Gln Glu Asp His Pro Asp Ile Val Thr 
                85                  90                  95      


Cys Pro Glu His Tyr Arg Gln Pro Leu Asn Val Tyr Cys Leu Leu Asp 
            100                 105                 110         


Lys Lys Leu Val Cys Gly His Cys Leu Thr Ile Gly Gln His His Gly 
        115                 120                 125             


His Pro Ile Asp Asp Leu Gln Ser Ala Tyr Leu Lys Glu Lys Asp Thr 
    130                 135                 140                 


Pro Gln Lys Leu Leu Glu Gln Leu Thr Asp Thr His Trp Thr Asp Leu 
145                 150                 155                 160 


Thr His Leu Ile Glu Lys Leu Lys Glu Gln Lys Ser His Ser Glu Lys 
                165                 170                 175     


Met Ile Gln Gly Asp Lys Glu Ala Val Leu Gln Tyr Phe Lys Glu Leu 
            180                 185                 190         


Asn Asp Thr Leu Glu Gln Lys Lys Lys Ser Phe Leu Thr Ala Leu Cys 
        195                 200                 205             


Asp Val Gly Asn Leu Ile Asn Gln Glu Tyr Thr Pro Gln Ile Glu Arg 
    210                 215                 220                 


Met Lys Glu Ile Arg Glu Gln Gln Leu Glu Leu Met Ala Leu Thr Ile 
225                 230                 235                 240 


Ser Leu Gln Glu Glu Ser Pro Leu Lys Phe Leu Glu Lys Val Asp Asp 
                245                 250                 255     


Val Arg Gln His Val Gln Ile Leu Lys Gln Arg Pro Leu Pro Glu Val 
            260                 265                 270         


Gln Pro Val Glu Ile Tyr Pro Arg Val Ser Lys Ile Leu Lys Glu Glu 
        275                 280                 285             


Trp Ser Arg Thr Glu Ile Gly Gln Ile Lys Asn Val Leu Ile Pro Lys 
    290                 295                 300                 


Met Lys Ile Ser Pro Lys Arg Met Ser Cys Ser Trp Pro Gly Lys Asp 
305                 310                 315                 320 


Glu Lys Glu Val Glu Phe Leu Lys Ile Leu Asn Ile Val Val Val Thr 
                325                 330                 335     


Leu Ile Ser Val Ile Leu Met Ser Ile Leu Phe Phe Asn Gln His Ile 
            340                 345                 350         


Ile Thr Phe Leu Ser Glu Ile Thr Leu Ile Trp Phe Ser Glu Ala Ser 
        355                 360                 365             


Leu Ser Val Tyr Gln Ser Leu Ser Asn Ser Leu His Lys Val Lys Asn 
    370                 375                 380                 


Ile Leu Cys His Ile Phe Tyr Leu Leu Lys Glu Phe Val Trp Lys Ile 
385                 390                 395                 400 


Val Ser His 
            


<210>  6335
<211>  905
<212>  PRT
<213>  Homo sapiens

<400>  6335

Met Pro Val Arg Arg Gly His Val Ala Pro Gln Asn Thr Tyr Leu Asp 
1               5                   10                  15      


Thr Ile Ile Arg Lys Phe Glu Gly Gln Ser Arg Lys Phe Leu Ile Ala 
            20                  25                  30          


Asn Ala Gln Met Glu Asn Cys Ala Ile Ile Tyr Cys Asn Asp Gly Phe 
        35                  40                  45              


Cys Glu Leu Phe Gly Tyr Ser Arg Val Glu Val Met Gln Gln Pro Cys 
    50                  55                  60                  


Thr Cys Asp Phe Leu Thr Gly Pro Asn Thr Pro Ser Ser Ala Val Ser 
65                  70                  75                  80  


Arg Leu Ala Gln Ala Leu Leu Gly Ala Glu Glu Cys Lys Val Asp Ile 
                85                  90                  95      


Leu Tyr Tyr Arg Lys Asp Ala Ser Ser Phe Arg Cys Leu Val Asp Val 
            100                 105                 110         


Val Pro Val Lys Asn Glu Asp Gly Ala Val Ile Met Phe Ile Leu Asn 
        115                 120                 125             


Phe Glu Asp Leu Ala Gln Leu Leu Ala Lys Cys Ser Ser Arg Ser Leu 
    130                 135                 140                 


Ser Gln Arg Leu Leu Ser Gln Ser Phe Leu Gly Ser Glu Gly Ser His 
145                 150                 155                 160 


Gly Arg Pro Gly Gly Pro Gly Pro Gly Thr Gly Arg Gly Lys Tyr Arg 
                165                 170                 175     


Thr Ile Ser Gln Ile Pro Gln Phe Thr Leu Asn Phe Val Glu Phe Asn 
            180                 185                 190         


Leu Glu Lys His Arg Ser Ser Ser Thr Thr Glu Ile Glu Ile Ile Ala 
        195                 200                 205             


Pro His Lys Val Val Glu Arg Thr Gln Asn Val Thr Glu Lys Val Thr 
    210                 215                 220                 


Gln Val Leu Ser Leu Gly Ala Asp Val Leu Pro Glu Tyr Lys Leu Gln 
225                 230                 235                 240 


Ala Pro Arg Ile His Arg Trp Thr Ile Leu His Tyr Ser Pro Phe Lys 
                245                 250                 255     


Ala Val Trp Asp Trp Leu Ile Leu Leu Leu Val Ile Tyr Thr Ala Val 
            260                 265                 270         


Phe Thr Pro Tyr Ser Ala Ala Phe Leu Leu Ser Asp Gln Asp Glu Ser 
        275                 280                 285             


Arg Arg Gly Ala Cys Ser Tyr Thr Cys Ser Pro Leu Thr Val Val Asp 
    290                 295                 300                 


Leu Ile Val Asp Ile Met Phe Val Val Asp Ile Val Ile Asn Phe Arg 
305                 310                 315                 320 


Thr Thr Tyr Val Asn Thr Asn Asp Glu Val Val Ser His Pro Arg Arg 
                325                 330                 335     


Ile Ala Val His Tyr Phe Lys Gly Trp Phe Leu Ile Asp Met Val Ala 
            340                 345                 350         


Ala Ile Pro Phe Asp Leu Leu Ile Phe Arg Thr Gly Ser Asp Glu Thr 
        355                 360                 365             


Thr Thr Leu Ile Gly Leu Leu Lys Thr Ala Arg Leu Leu Arg Leu Val 
    370                 375                 380                 


Arg Val Ala Arg Lys Leu Asp Arg Tyr Ser Glu Tyr Gly Ala Ala Val 
385                 390                 395                 400 


Leu Phe Leu Leu Met Cys Thr Phe Ala Leu Ile Ala His Trp Leu Ala 
                405                 410                 415     


Cys Ile Cys Ser Leu Thr Ser Val Gly Phe Gly Asn Val Ser Pro Asn 
            420                 425                 430         


Thr Asn Ser Glu Lys Val Phe Ser Ile Cys Val Met Leu Ile Gly Ser 
        435                 440                 445             


Leu Met Tyr Ala Ser Ile Phe Gly Asn Val Ser Ala Ile Ile Gln Arg 
    450                 455                 460                 


Leu Tyr Ser Gly Thr Ala Arg Tyr His Thr Gln Met Leu Arg Val Lys 
465                 470                 475                 480 


Glu Phe Ile Arg Phe His Gln Ile Pro Asn Pro Leu Arg Gln Arg Leu 
                485                 490                 495     


Glu Glu Tyr Phe Gln His Ala Trp Ser Tyr Thr Asn Gly Ile Asp Met 
            500                 505                 510         


Asn Ala Val Leu Lys Gly Phe Pro Glu Cys Leu Gln Ala Asp Ile Cys 
        515                 520                 525             


Leu His Leu His Arg Ala Leu Leu Gln His Cys Pro Ala Phe Ser Gly 
    530                 535                 540                 


Ala Gly Lys Gly Cys Leu Arg Ala Leu Ala Val Lys Phe Lys Thr Thr 
545                 550                 555                 560 


His Ala Pro Pro Gly Asp Thr Leu Val His Leu Gly Asp Val Leu Ser 
                565                 570                 575     


Thr Leu Tyr Phe Ile Ser Arg Gly Ser Ile Glu Ile Leu Arg Asp Asp 
            580                 585                 590         


Val Val Val Ala Ile Leu Gly Lys Asn Asp Ile Phe Gly Glu Pro Val 
        595                 600                 605             


Ser Leu His Ala Gln Pro Gly Lys Ser Ser Ala Asp Val Arg Ala Leu 
    610                 615                 620                 


Thr Tyr Cys Asp Leu His Lys Ile Gln Arg Ala Asp Leu Leu Glu Val 
625                 630                 635                 640 


Leu Asp Met Tyr Pro Ala Phe Ala Glu Ser Phe Trp Ser Lys Leu Glu 
                645                 650                 655     


Val Thr Phe Asn Leu Arg Asp Ala Ala Gly Gly Leu His Ser Ser Pro 
            660                 665                 670         


Arg Gln Ala Pro Gly Ser Gln Asp His Gln Gly Phe Phe Leu Ser Asp 
        675                 680                 685             


Asn Gln Ser Asp Ala Ala Pro Pro Leu Ser Ile Ser Asp Ala Ser Gly 
    690                 695                 700                 


Leu Trp Pro Glu Leu Leu Gln Glu Met Pro Pro Arg His Ser Pro Gln 
705                 710                 715                 720 


Ser Pro Gln Glu Asp Pro Asp Cys Trp Pro Leu Lys Leu Gly Ser Arg 
                725                 730                 735     


Leu Glu Gln Leu Gln Ala Gln Met Asn Arg Leu Glu Ser Arg Val Ser 
            740                 745                 750         


Ser Asp Leu Ser Arg Ile Leu Gln Leu Leu Gln Lys Pro Met Pro Gln 
        755                 760                 765             


Gly His Ala Ser Tyr Ile Leu Glu Ala Pro Ala Ser Asn Asp Leu Ala 
    770                 775                 780                 


Leu Val Pro Ile Ala Ser Glu Thr Thr Ser Pro Gly Pro Arg Leu Pro 
785                 790                 795                 800 


Gln Gly Phe Leu Pro Pro Ala Gln Thr Pro Ser Tyr Gly Asp Leu Asp 
                805                 810                 815     


Asp Cys Ser Pro Lys His Arg Asn Ser Ser Pro Arg Met Pro His Leu 
            820                 825                 830         


Ala Val Ala Thr Asp Lys Thr Leu Ala Pro Ser Ser Glu Gln Glu Gln 
        835                 840                 845             


Pro Glu Gly Leu Trp Pro Pro Leu Ala Ser Pro Leu His Pro Leu Glu 
    850                 855                 860                 


Val Gln Gly Leu Ile Cys Gly Pro Cys Phe Ser Ser Leu Pro Glu His 
865                 870                 875                 880 


Leu Gly Ser Val Pro Lys Gln Leu Asp Phe Gln Arg His Gly Ser Asp 
                885                 890                 895     


Pro Gly Phe Ala Gly Ser Trp Gly His 
            900                 905 


<210>  6336
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  6336

Met Glu Arg Val Thr Leu Ala Leu Leu Leu Leu Ala Gly Leu Thr Ala 
1               5                   10                  15      


Leu Glu Ala Asn Asp Pro Phe Ala Asn Lys Asp Asp Pro Phe Tyr Tyr 
            20                  25                  30          


Asp Trp Lys Asn Leu Gln Leu Ser Gly Leu Ile Cys Gly Gly Leu Leu 
        35                  40                  45              


Ala Ile Ala Gly Ile Ala Ala Val Leu Ser Gly Lys Cys Lys Cys Lys 
    50                  55                  60                  


Ser Ser Gln Lys Gln His Ser Pro Val Pro Glu Lys Ala Ile Pro Leu 
65                  70                  75                  80  


Ile Thr Pro Gly Ser Ala Thr Thr Cys 
                85                  


<210>  6337
<211>  732
<212>  PRT
<213>  Homo sapiens

<400>  6337

Met Pro Val Arg Arg Gly His Val Ala Pro Gln Asn Thr Phe Leu Gly 
1               5                   10                  15      


Thr Ile Ile Arg Lys Phe Glu Gly Gln Asn Lys Lys Phe Ile Ile Ala 
            20                  25                  30          


Asn Ala Arg Val Gln Asn Cys Ala Ile Ile Tyr Cys Asn Asp Gly Phe 
        35                  40                  45              


Cys Glu Met Thr Gly Phe Ser Arg Pro Asp Val Met Gln Lys Pro Cys 
    50                  55                  60                  


Thr Cys Asp Phe Leu His Gly Pro Glu Thr Lys Arg His Asp Ile Ala 
65                  70                  75                  80  


Gln Ile Ala Gln Ala Leu Leu Gly Ser Glu Glu Arg Lys Val Glu Val 
                85                  90                  95      


Thr Tyr Tyr His Lys Asn Gly Ser Thr Phe Ile Cys Asn Thr His Ile 
            100                 105                 110         


Ile Pro Val Lys Asn Gln Glu Gly Val Ala Met Met Phe Ile Ile Asn 
        115                 120                 125             


Phe Glu Tyr Val Thr Asp Asn Glu Asn Ala Ala Thr Pro Glu Arg Val 
    130                 135                 140                 


Asn Pro Ile Leu Pro Ile Lys Thr Val Asn Arg Lys Phe Phe Gly Phe 
145                 150                 155                 160 


Lys Phe Pro Gly Leu Arg Val Leu Thr Tyr Arg Lys Gln Ser Leu Pro 
                165                 170                 175     


Gln Glu Asp Pro Asp Val Val Val Ile Asp Ser Ser Lys His Ser Asp 
            180                 185                 190         


Asp Ser Val Ala Met Lys His Phe Lys Ser Pro Thr Lys Glu Ser Cys 
        195                 200                 205             


Ser Pro Ser Glu Ala Asp Asp Thr Lys Ala Leu Ile Gln Pro Ser Lys 
    210                 215                 220                 


Cys Ser Pro Leu Val Asn Ile Ser Gly Pro Leu Asp His Ser Ser Pro 
225                 230                 235                 240 


Lys Arg Gln Trp Asp Arg Leu Tyr Pro Asp Met Leu Gln Ser Ser Ser 
                245                 250                 255     


Gln Leu Ser His Ser Arg Ser Arg Glu Ser Leu Cys Ser Ile Arg Arg 
            260                 265                 270         


Ala Ser Ser Val His Asp Ile Glu Gly Phe Gly Val His Pro Lys Asn 
        275                 280                 285             


Ile Phe Arg Asp Arg His Ala Ser Glu Gly Pro Phe Asn His Ile Lys 
    290                 295                 300                 


Ser Ser Leu Leu Gly Ser Thr Ser Asp Ser Asn Leu Asn Lys Tyr Ser 
305                 310                 315                 320 


Thr Ile Asn Lys Ile Pro Gln Leu Thr Leu Asn Phe Ser Glu Val Lys 
                325                 330                 335     


Thr Glu Lys Lys Asn Ser Ser Pro Pro Ser Ser Asp Lys Thr Ile Ile 
            340                 345                 350         


Ala Pro Lys Val Lys Asp Arg Thr His Asn Val Thr Glu Lys Val Thr 
        355                 360                 365             


Gln Val Leu Ser Leu Gly Ala Asp Val Leu Pro Glu Tyr Lys Leu Gln 
    370                 375                 380                 


Thr Pro Arg Ile Asn Lys Phe Thr Ile Leu His Tyr Ser Pro Phe Lys 
385                 390                 395                 400 


Ala Val Trp Asp Trp Leu Ile Leu Leu Leu Val Ile Tyr Thr Ala Ile 
                405                 410                 415     


Phe Thr Pro Tyr Ser Ala Ala Phe Leu Leu Asn Asp Arg Glu Glu Gln 
            420                 425                 430         


Lys Arg Arg Glu Cys Gly Tyr Ser Cys Ser Pro Leu Asn Val Val Asp 
        435                 440                 445             


Leu Ile Val Asp Ile Met Phe Ile Ile Asp Ile Leu Ile Asn Phe Arg 
    450                 455                 460                 


Thr Thr Tyr Val Asn Gln Asn Glu Glu Val Val Ser Asp Pro Ala Lys 
465                 470                 475                 480 


Ile Ala Ile His Tyr Phe Lys Gly Trp Phe Leu Ile Asp Met Val Ala 
                485                 490                 495     


Ala Ile Pro Phe Asp Leu Leu Ile Phe Gly Ser Gly Ser Asp Glu Thr 
            500                 505                 510         


Thr Thr Leu Ile Gly Leu Leu Lys Thr Ala Arg Leu Leu Arg Leu Val 
        515                 520                 525             


Arg Val Ala Arg Lys Leu Asp Arg Tyr Ser Glu Tyr Gly Ala Ala Val 
    530                 535                 540                 


Leu Met Leu Leu Met Cys Ile Phe Ala Leu Ile Ala His Trp Leu Ala 
545                 550                 555                 560 


Cys Ile Trp Tyr Ala Ile Gly Asn Val Glu Arg Pro Tyr Leu Thr Asp 
                565                 570                 575     


Lys Ile Gly Trp Leu Asp Ser Leu Gly Gln Gln Ile Gly Lys Arg Tyr 
            580                 585                 590         


Asn Asp Ser Asp Ser Ser Ser Gly Pro Ser Ile Lys Asp Lys Tyr Val 
        595                 600                 605             


Thr Ala Leu Tyr Phe Thr Phe Ser Ser Leu Thr Ser Val Gly Phe Gly 
    610                 615                 620                 


Asn Val Ser Pro Asn Thr Asn Ser Glu Lys Ile Phe Ser Ile Cys Val 
625                 630                 635                 640 


Met Leu Ile Gly Ser Leu Met Tyr Ala Ser Ile Phe Gly Asn Val Ser 
                645                 650                 655     


Ala Ile Ile Gln Arg Leu Tyr Ser Gly Thr Ala Arg Tyr His Met Gln 
            660                 665                 670         


Met Leu Arg Val Lys Glu Phe Ile Arg Phe His Gln Ile Pro Asn Pro 
        675                 680                 685             


Leu Arg Gln Arg Leu Glu Glu Tyr Phe Gln His Ala Trp Thr Tyr Thr 
    690                 695                 700                 


Asn Gly Ile Asp Met Asn Met Val Cys Met Ser Val Phe Gln Asn Glu 
705                 710                 715                 720 


Ser Ala Ala Gly Ile Ile Val Ile Ala Lys Met Glu 
                725                 730         


<210>  6338
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  6338

Met Gly Arg Trp Ala Leu Asp Val Ala Phe Leu Trp Lys Ala Val Leu 
1               5                   10                  15      


Thr Leu Gly Leu Val Leu Leu Tyr Tyr Cys Phe Ser Ile Gly Ile Thr 
            20                  25                  30          


Phe Tyr Asn Lys Trp Leu Thr Lys Ser Phe His Phe Pro Leu Phe Met 
        35                  40                  45              


Thr Met Leu His Leu Ala Val Ile Phe Leu Phe Ser Ala Leu Ser Arg 
    50                  55                  60                  


Ala Leu Val Gln Cys Ser Ser His Arg Ala Arg Val Val Leu Ser Trp 
65                  70                  75                  80  


Ala Asp Tyr Leu Arg Arg Val Ala Pro Thr Ala Leu Ala Thr Ala Leu 
                85                  90                  95      


Asp Val Gly Leu Ser Asn Trp Ser Phe Leu Tyr Val Thr Val Ser Leu 
            100                 105                 110         


Tyr Thr Met Thr Lys Ser Ser Ala Val Leu Phe Ile Leu Ile Phe Ser 
        115                 120                 125             


Leu Ile Phe Lys Leu Glu Glu Leu Arg Ala Ala Leu Val Leu Val Val 
    130                 135                 140                 


Leu Leu Ile Ala Gly Gly Leu Phe Met Phe Thr Tyr Lys Ser Thr Gln 
145                 150                 155                 160 


Phe Asn Val Glu Gly Phe Ala Leu Val Leu Gly Ala Ser Phe Ile Gly 
                165                 170                 175     


Gly Ile Arg Trp Thr Leu Thr Gln Met Leu Leu Gln Lys Ala Glu Leu 
            180                 185                 190         


Gly Leu Gln Asn Pro Ile Asp Thr Met Phe His Leu Gln Pro Leu Met 
        195                 200                 205             


Phe Leu Gly Leu Phe Pro Leu Phe Ala Val Phe Glu Gly Leu His Leu 
    210                 215                 220                 


Ser Thr Ser Glu Lys Ile Phe Arg Phe Gln Asp Thr Gly Leu Leu Leu 
225                 230                 235                 240 


Arg Val Leu Gly Ser Leu Phe Leu Gly Gly Ile Leu Ala Phe Gly Leu 
                245                 250                 255     


Gly Phe Ser Glu Phe Leu Leu Val Ser Arg Thr Ser Ser Leu Thr Leu 
            260                 265                 270         


Ser Ile Ala Gly Ile Phe Lys Glu Val Cys Thr Leu Leu Leu Ala Ala 
        275                 280                 285             


His Leu Leu Gly Asp Gln Ile Ser Leu Leu Asn Trp Leu Gly Phe Ala 
    290                 295                 300                 


Leu Cys Leu Ser Gly Ile Ser Leu His Val Ala Leu Lys Ala Leu His 
305                 310                 315                 320 


Ser Arg Gly Asp Gly Gly Pro Lys Ala Leu Lys Gly Leu Gly Ser Ser 
                325                 330                 335     


Pro Asp Leu Glu Leu Leu Leu Arg Ser Ser Gln Arg Glu Glu Gly Asp 
            340                 345                 350         


Asn Glu Glu Glu Glu Tyr Phe Val Ala Gln Gly Gln Gln 
        355                 360                 365 


<210>  6339
<211>  1001
<212>  PRT
<213>  Homo sapiens

<400>  6339

Met Glu Ala Ala His Ala Lys Thr Thr Glu Glu Cys Leu Ala Tyr Phe 
1               5                   10                  15      


Gly Val Ser Glu Thr Thr Gly Leu Thr Pro Asp Gln Val Lys Arg Asn 
            20                  25                  30          


Leu Glu Lys Tyr Gly Leu Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              


Leu Trp Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Ile Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Ala Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Arg Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Ile Arg Ile Leu Ala Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Glu 
            180                 185                 190         


Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Leu Gly Ile Val Ala 
    210                 215                 220                 


Thr Thr Gly Val Gly Thr Glu Ile Gly Lys Ile Arg Asp Gln Met Ala 
225                 230                 235                 240 


Ala Thr Glu Gln Asp Lys Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Val Ala Val Trp 
            260                 265                 270         


Leu Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             


Phe Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Lys Met Phe Ile 
        355                 360                 365             


Ile Asp Lys Val Asp Gly Asp Ile Cys Leu Leu Asn Glu Phe Ser Ile 
    370                 375                 380                 


Thr Gly Ser Thr Tyr Ala Pro Glu Gly Glu Val Leu Lys Asn Asp Lys 
385                 390                 395                 400 


Pro Val Arg Pro Gly Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ser Leu Asp Phe Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Thr Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asn Thr Asp Val Arg Ser Leu Ser Lys 
    450                 455                 460                 


Val Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Arg Gln Leu Met Lys 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Ser Pro Ala Lys Ser Ser Arg Ala Ala Val Gly Asn Lys Met 
            500                 505                 510         


Phe Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Asn Tyr Val 
        515                 520                 525             


Arg Val Gly Thr Thr Arg Val Pro Leu Thr Gly Pro Val Lys Glu Lys 
    530                 535                 540                 


Ile Met Ala Val Ile Lys Glu Trp Gly Thr Gly Arg Asp Thr Leu Arg 
545                 550                 555                 560 


Cys Leu Ala Leu Ala Thr Arg Asp Thr Pro Pro Lys Arg Glu Glu Met 
                565                 570                 575     


Val Leu Asp Asp Ser Ala Arg Phe Leu Glu Tyr Glu Thr Asp Leu Thr 
            580                 585                 590         


Phe Val Gly Val Val Gly Met Leu Asp Pro Pro Arg Lys Glu Val Thr 
        595                 600                 605             


Gly Ser Ile Gln Leu Cys Arg Asp Ala Gly Ile Arg Val Ile Met Ile 
    610                 615                 620                 


Thr Gly Asp Asn Lys Gly Thr Ala Ile Ala Ile Cys Arg Arg Ile Gly 
625                 630                 635                 640 


Ile Phe Gly Glu Asn Glu Glu Val Ala Asp Arg Ala Tyr Thr Gly Arg 
                645                 650                 655     


Glu Phe Asp Asp Leu Pro Leu Ala Glu Gln Arg Glu Ala Cys Arg Arg 
            660                 665                 670         


Ala Cys Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val 
        675                 680                 685             


Glu Tyr Leu Gln Ser Tyr Asp Glu Ile Thr Ala Met Thr Gly Asp Gly 
    690                 695                 700                 


Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met 
705                 710                 715                 720 


Gly Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala 
                725                 730                 735     


Asp Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala 
            740                 745                 750         


Ile Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn 
        755                 760                 765             


Val Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Leu Pro 
    770                 775                 780                 


Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp 
785                 790                 795                 800 


Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile 
                805                 810                 815     


Met Asp Arg Pro Pro Arg Ser Pro Lys Glu Pro Leu Ile Ser Gly Trp 
            820                 825                 830         


Leu Phe Phe Arg Tyr Met Ala Ile Gly Gly Tyr Val Gly Ala Ala Thr 
        835                 840                 845             


Val Gly Ala Ala Ala Trp Trp Phe Leu Tyr Ala Glu Asp Gly Pro His 
    850                 855                 860                 


Val Asn Tyr Ser Gln Leu Thr His Phe Met Gln Cys Thr Glu Asp Asn 
865                 870                 875                 880 


Thr His Phe Glu Gly Ile Asp Cys Glu Val Phe Glu Ala Pro Glu Pro 
                885                 890                 895     


Met Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala 
            900                 905                 910         


Leu Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp 
        915                 920                 925             


Val Asn Ile Trp Leu Leu Gly Ser Ile Cys Leu Ser Met Ser Leu His 
    930                 935                 940                 


Phe Leu Ile Leu Tyr Val Asp Pro Leu Pro Met Ile Phe Lys Leu Arg 
945                 950                 955                 960 


Ala Leu Asp Leu Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro 
                965                 970                 975     


Val Ile Gly Leu Asp Glu Ile Leu Lys Phe Val Ala Arg Asn Tyr Leu 
            980                 985                 990         


Glu Asp Pro Glu Asp Glu Arg Arg  Lys 
        995                 1000     


<210>  6340
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  6340

Met Leu Arg Leu Tyr Val Leu Val Met Gly Val Ser Ala Phe Thr Leu 
1               5                   10                  15      


Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg Gly 
            20                  25                  30          


Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala Leu 
        35                  40                  45              


Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro Arg 
    50                  55                  60                  


Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro Gly 
65                  70                  75                  80  


Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu Leu 
                85                  90                  95      


Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg Asn 
            100                 105                 110         


Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu Asn 
        115                 120                 125             


Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr Leu 
    130                 135                 140                 


Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr Arg 
145                 150                 155                 160 


Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu Leu 
                165                 170                 175     


Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His Leu 
            180                 185                 190         


Leu Val His Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys Val 
        195                 200                 205             


Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser Ile 
    210                 215                 220                 


Glu Leu Arg Ile Lys Lys Lys Lys Glu Glu Thr Ile Pro Val Ile Ile 
225                 230                 235                 240 


Ser Pro Leu Lys Thr Ile Ser Ala Ser Leu Gly Ser Arg Leu Thr Ile 
                245                 250                 255     


Pro Cys Lys Val Phe Leu Gly Thr Gly Thr Pro Leu Thr Thr Met Leu 
            260                 265                 270         


Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser Ala Tyr Pro Gly Gly 
        275                 280                 285             


Arg Val Thr Glu Gly Pro Arg Gln 
    290                 295     


<210>  6341
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  6341

Met Val Thr Leu Arg Lys Arg Thr Leu Lys Val Leu Thr Phe Leu Val 
1               5                   10                  15      


Leu Phe Ile Phe Leu Thr Ser Phe Phe Leu Asn Tyr Ser His Thr Met 
            20                  25                  30          


Val Ala Thr Thr Trp Phe Pro Lys Gln Met Val Leu Glu Leu Ser Glu 
        35                  40                  45              


Asn Leu Lys Arg Leu Ile Lys His Arg Pro Cys Thr Cys Thr His Cys 
    50                  55                  60                  


Ile Gly Gln Arg Lys Leu Ser Ala Trp Phe Asp Glu Arg Phe Asn Gln 
65                  70                  75                  80  


Thr Met Gln Pro Leu Leu Thr Ala Gln Asn Ala Leu Leu Glu Asp Asp 
                85                  90                  95      


Thr Tyr Arg Trp Trp Leu Arg Leu Gln Arg Glu Lys Lys Pro Asn Asn 
            100                 105                 110         


Leu Asn Asp Thr Ile Lys Glu Leu Phe Arg Val Val Pro Gly Asn Val 
        115                 120                 125             


Asp Pro Met Leu Glu Lys Arg Ser Val Gly Cys Arg Arg Cys Ala Val 
    130                 135                 140                 


Val Gly Asn Ser Gly Asn Leu Arg Glu Ser Ser Tyr Gly Pro Glu Ile 
145                 150                 155                 160 


Asp Ser His Asp Phe Val Leu Arg Met Asn Lys Ala Pro Thr Ala Gly 
                165                 170                 175     


Phe Glu Ala Asp Val Gly Thr Lys Thr Thr His His Leu Val Tyr Pro 
            180                 185                 190         


Glu Ser Phe Arg Glu Leu Gly Asp Asn Val Ser Met Ile Leu Val Pro 
        195                 200                 205             


Phe Lys Thr Ile Asp Leu Glu Trp Val Val Ser Ala Ile Thr Thr Gly 
    210                 215                 220                 


Thr Ile Ser His Thr Tyr Ile Pro Val Pro Ala Lys Ile Arg Val Lys 
225                 230                 235                 240 


Gln Asp Lys Ile Leu Ile Tyr His Pro Ala Phe Ile Lys Tyr Val Phe 
                245                 250                 255     


Asp Asn Trp Leu Gln Gly His Gly Arg Tyr Pro Ser Thr Gly Ile Leu 
            260                 265                 270         


Ser Val Ile Phe Ser Met His Val Cys Asp Glu Val Asp Leu Tyr Gly 
        275                 280                 285             


Phe Gly Ala Asp Ser Lys Gly Asn Trp His His Tyr Trp Glu Asn Asn 
    290                 295                 300                 


Pro Ser Ala Gly Ala Phe Arg Lys Thr Gly Val His Asp Ala Asp Phe 
305                 310                 315                 320 


Glu Ser Asn Val Thr Ala Thr Leu Ala Ser Ile Asn Lys Ile Arg Ile 
                325                 330                 335     


Phe Lys Gly Arg 
            340 


<210>  6342
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  6342

Met Ala Pro Ser Leu Trp Lys Gly Leu Val Gly Ile Gly Leu Phe Ala 
1               5                   10                  15      


Leu Ala His Ala Ala Phe Ser Ala Ala Gln His Arg Ser Tyr Met Arg 
            20                  25                  30          


Leu Thr Glu Lys Glu Asp Glu Ser Leu Pro Ile Asp Ile Val Leu Gln 
        35                  40                  45              


Thr Leu Leu Ala Phe Ala Val Thr Cys Tyr Gly Ile Val His Ile Ala 
    50                  55                  60                  


Gly Glu Phe Lys Asp Met Asp Ala Thr Ser Glu Leu Lys Asn Lys Thr 
65                  70                  75                  80  


Phe Asp Thr Leu Arg Asn His Pro Ser Phe Tyr Val Phe Asn His Arg 
                85                  90                  95      


Gly Arg Val Leu Phe Arg Pro Ser Asp Thr Ala Asn Ser Ser Asn Gln 
            100                 105                 110         


Asp Ala Leu Ser Ser Asn Thr Ser Leu Lys Leu Arg Lys Leu Glu Ser 
        115                 120                 125             


Leu Arg Arg 
    130     


<210>  6343
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  6343

Met Asp Arg Pro Gly Phe Val Ala Ala Leu Val Ala Gly Gly Val Ala 
1               5                   10                  15      


Gly Val Ser Val Asp Leu Ile Leu Phe Pro Leu Asp Thr Ile Lys Thr 
            20                  25                  30          


Arg Leu Gln Ser Pro Gln Gly Phe Ser Lys Ala Gly Gly Phe His Gly 
        35                  40                  45              


Ile Tyr Ala Gly Val Pro Ser Ala Ala Ile Gly Ser Phe Pro Asn Ala 
    50                  55                  60                  


Ala Ala Phe Phe Ile Thr Tyr Glu Tyr Val Lys Trp Phe Leu His Ala 
65                  70                  75                  80  


Asp Ser Ser Ser Tyr Leu Thr Pro Met Lys His Met Leu Ala Ala Ser 
                85                  90                  95      


Ala Gly Glu Val Val Ala Cys Leu Ile Arg Val Pro Ser Glu Val Val 
            100                 105                 110         


Lys Gln Arg Ala Gln Val Ser Ala Ser Thr Arg Thr Phe Gln Ile Phe 
        115                 120                 125             


Ser Asn Ile Leu Tyr Glu Glu Gly Ile Gln Gly Leu Tyr Arg Gly Tyr 
    130                 135                 140                 


Lys Ser Thr Val Leu Arg Glu Ile Pro Phe Ser Leu Val Gln Phe Pro 
145                 150                 155                 160 


Leu Trp Glu Ser Leu Lys Ala Leu Trp Ser Trp Arg Gln Asp His Val 
                165                 170                 175     


Val Asp Ser Trp Gln Ser Ala Val Cys Gly Ala Phe Ala Gly Gly Phe 
            180                 185                 190         


Ala Ala Ala Val Thr Thr Pro Leu Asp Val Ala Lys Thr Arg Ile Thr 
        195                 200                 205             


Leu Ala Lys Ala Gly Ser Ser Thr Ala Asp Gly Asn Val Leu Ser Val 
    210                 215                 220                 


Leu His Gly Val Trp Arg Ser Gln Gly Leu Ala Gly Leu Phe Ala Gly 
225                 230                 235                 240 


Val Phe Pro Arg Met Ala Ala Ile Ser Leu Gly Gly Phe Ile Phe Leu 
                245                 250                 255     


Gly Ala Tyr Asp Arg Thr His Ser Leu Leu Leu Glu Val Gly Arg Lys 
            260                 265                 270         


Ser Pro 
        


<210>  6344
<211>  531
<212>  PRT
<213>  Homo sapiens

<400>  6344

Met Leu Pro Ile Thr Asp Arg Leu Leu His Leu Leu Gly Leu Glu Lys 
1               5                   10                  15      


Thr Ala Phe Arg Ile Tyr Ala Val Ser Thr Leu Leu Leu Phe Leu Leu 
            20                  25                  30          


Phe Phe Leu Phe Arg Leu Leu Leu Arg Phe Leu Arg Leu Cys Arg Ser 
        35                  40                  45              


Phe Tyr Ile Thr Cys Arg Arg Leu Arg Cys Phe Pro Gln Pro Pro Arg 
    50                  55                  60                  


Arg Asn Trp Leu Leu Gly His Leu Gly Met Tyr Leu Pro Asn Glu Ala 
65                  70                  75                  80  


Gly Leu Gln Asp Glu Lys Lys Val Leu Asp Asn Met His His Val Leu 
                85                  90                  95      


Leu Val Trp Met Gly Pro Val Leu Pro Leu Leu Val Leu Val His Pro 
            100                 105                 110         


Asp Tyr Ile Lys Pro Leu Leu Gly Ala Ser Ala Ala Ile Ala Pro Lys 
        115                 120                 125             


Asp Asp Leu Phe Tyr Gly Phe Leu Lys Pro Trp Leu Gly Asp Gly Leu 
    130                 135                 140                 


Leu Leu Ser Lys Gly Asp Lys Trp Ser Arg His Arg Arg Leu Leu Thr 
145                 150                 155                 160 


Pro Ala Phe His Phe Asp Ile Leu Lys Pro Tyr Met Lys Ile Phe Asn 
                165                 170                 175     


Gln Ser Ala Asp Ile Met His Ala Lys Trp Arg His Leu Ala Glu Gly 
            180                 185                 190         


Ser Ala Val Ser Leu Asp Met Phe Glu His Ile Ser Leu Met Thr Leu 
        195                 200                 205             


Asp Ser Leu Gln Lys Cys Val Phe Ser Tyr Asn Ser Asn Cys Gln Glu 
    210                 215                 220                 


Lys Met Ser Asp Tyr Ile Ser Ala Ile Ile Glu Leu Ser Ala Leu Ser 
225                 230                 235                 240 


Val Arg Arg Gln Tyr Arg Leu His His Tyr Leu Asp Phe Ile Tyr Tyr 
                245                 250                 255     


Arg Ser Ala Asp Gly Arg Arg Phe Arg Gln Ala Cys Asp Met Val His 
            260                 265                 270         


His Phe Thr Thr Glu Val Ile Gln Glu Arg Arg Arg Ala Leu Arg Gln 
        275                 280                 285             


Gln Gly Ala Glu Ala Trp Leu Lys Ala Lys Gln Gly Lys Thr Leu Asp 
    290                 295                 300                 


Phe Ile Asp Val Leu Leu Leu Ala Arg Asp Glu Asp Gly Lys Glu Leu 
305                 310                 315                 320 


Ser Asp Glu Asp Ile Arg Ala Glu Ala Asp Thr Phe Met Phe Glu Gly 
                325                 330                 335     


His Asp Thr Thr Ser Ser Gly Ile Ser Trp Met Leu Phe Asn Leu Ala 
            340                 345                 350         


Lys Tyr Pro Glu Tyr Gln Glu Lys Cys Arg Glu Glu Ile Gln Glu Val 
        355                 360                 365             


Met Lys Gly Arg Glu Leu Glu Glu Leu Glu Trp Asp Asp Leu Thr Gln 
    370                 375                 380                 


Leu Pro Phe Thr Thr Met Cys Ile Lys Glu Ser Leu Arg Gln Tyr Pro 
385                 390                 395                 400 


Pro Val Thr Leu Val Ser Arg Gln Cys Thr Glu Asp Ile Lys Leu Pro 
                405                 410                 415     


Asp Gly Arg Ile Ile Pro Lys Gly Ile Ile Cys Leu Val Ser Ile Tyr 
            420                 425                 430         


Gly Thr His His Asn Pro Thr Val Trp Pro Asp Ser Lys Val Tyr Asn 
        435                 440                 445             


Pro Tyr Arg Phe Asp Pro Asp Asn Pro Gln Gln Arg Ser Pro Leu Ala 
    450                 455                 460                 


Tyr Val Pro Phe Ser Ala Gly Pro Arg Asn Cys Ile Gly Gln Ser Phe 
465                 470                 475                 480 


Ala Met Ala Glu Leu Arg Val Val Val Ala Leu Thr Leu Leu Arg Phe 
                485                 490                 495     


Arg Leu Ser Val Asp Arg Thr Arg Lys Val Arg Arg Lys Pro Glu Leu 
            500                 505                 510         


Ile Leu Arg Thr Glu Asn Gly Leu Trp Leu Lys Val Glu Pro Leu Pro 
        515                 520                 525             


Pro Arg Ala 
    530     


<210>  6345
<211>  719
<212>  PRT
<213>  Homo sapiens

<400>  6345

Met Phe Val Gly Val Ala Arg His Ser Gly Ser Gln Asp Glu Val Ser 
1               5                   10                  15      


Arg Gly Val Glu Pro Leu Glu Ala Ala Arg Ala Gln Pro Ala Lys Asp 
            20                  25                  30          


Arg Arg Ala Lys Gly Thr Pro Lys Ser Ser Lys Pro Gly Lys Lys His 
        35                  40                  45              


Arg Tyr Leu Arg Leu Leu Pro Glu Ala Leu Ile Arg Phe Gly Gly Phe 
    50                  55                  60                  


Arg Lys Arg Lys Lys Ala Lys Ser Ser Val Ser Lys Lys Pro Gly Glu 
65                  70                  75                  80  


Val Asp Asp Ser Leu Glu Gln Pro Cys Gly Leu Gly Cys Leu Val Ser 
                85                  90                  95      


Thr Cys Cys Glu Cys Cys Asn Asn Ile Arg Cys Phe Met Ile Phe Tyr 
            100                 105                 110         


Cys Ile Leu Leu Ile Cys Gln Gly Val Val Phe Gly Leu Ile Asp Val 
        115                 120                 125             


Ser Ile Gly Asp Phe Gln Lys Glu Tyr Gln Leu Lys Thr Ile Glu Lys 
    130                 135                 140                 


Leu Ala Leu Glu Lys Ser Tyr Asp Ile Ser Ser Gly Leu Val Ala Ile 
145                 150                 155                 160 


Phe Ile Ala Phe Tyr Gly Asp Arg Lys Lys Val Ile Trp Phe Val Ala 
                165                 170                 175     


Ser Ser Phe Leu Ile Gly Leu Gly Ser Leu Leu Cys Ala Phe Pro Ser 
            180                 185                 190         


Ile Asn Glu Glu Asn Lys Gln Ser Lys Val Gly Ile Glu Asp Ile Cys 
        195                 200                 205             


Glu Glu Ile Lys Val Val Ser Gly Cys Gln Ser Ser Gly Ile Ser Phe 
    210                 215                 220                 


Gln Ser Lys Tyr Leu Ser Phe Phe Ile Leu Gly Gln Thr Val Gln Gly 
225                 230                 235                 240 


Ile Ala Gly Met Pro Leu Tyr Ile Leu Gly Ile Thr Phe Ile Asp Glu 
                245                 250                 255     


Asn Val Ala Thr His Ser Ala Gly Ile Tyr Leu Gly Ile Ala Glu Cys 
            260                 265                 270         


Thr Ser Met Ile Gly Tyr Ala Leu Gly Tyr Val Leu Gly Ala Pro Leu 
        275                 280                 285             


Val Lys Val Pro Glu Asn Thr Thr Ser Ala Thr Asn Thr Thr Val Asn 
    290                 295                 300                 


Asn Gly Ser Pro Glu Trp Leu Trp Thr Trp Trp Ile Asn Phe Leu Phe 
305                 310                 315                 320 


Ala Ala Val Val Ala Trp Cys Thr Leu Ile Pro Leu Ser Cys Phe Pro 
                325                 330                 335     


Asn Asn Met Pro Gly Ser Thr Arg Ile Lys Ala Arg Lys Arg Lys Gln 
            340                 345                 350         


Leu His Phe Phe Asp Ser Arg Leu Lys Asp Leu Lys Leu Gly Thr Asn 
        355                 360                 365             


Ile Lys Asp Leu Cys Ala Ala Leu Trp Ile Leu Met Lys Asn Pro Val 
    370                 375                 380                 


Leu Ile Cys Leu Ala Leu Ser Lys Ala Thr Glu Tyr Leu Val Ile Ile 
385                 390                 395                 400 


Gly Ala Ser Glu Phe Leu Pro Ile Tyr Leu Glu Asn Gln Phe Ile Leu 
                405                 410                 415     


Thr Pro Thr Val Ala Thr Thr Leu Ala Gly Leu Val Leu Ile Pro Gly 
            420                 425                 430         


Gly Ala Leu Gly Gln Leu Leu Gly Gly Val Ile Val Ser Thr Leu Glu 
        435                 440                 445             


Met Ser Cys Lys Ala Leu Met Arg Phe Ile Met Val Thr Ser Val Ile 
    450                 455                 460                 


Ser Leu Ile Leu Leu Val Phe Ile Ile Phe Val Arg Cys Asn Pro Val 
465                 470                 475                 480 


Gln Phe Ala Gly Ile Asn Glu Asp Tyr Asp Gly Thr Gly Lys Leu Gly 
                485                 490                 495     


Asn Leu Thr Ala Pro Cys Asn Glu Lys Cys Arg Cys Ser Ser Ser Ile 
            500                 505                 510         


Tyr Ser Ser Ile Cys Gly Arg Asp Asp Ile Glu Tyr Phe Ser Pro Cys 
        515                 520                 525             


Phe Ala Gly Cys Thr Tyr Ser Lys Ala Gln Asn Gln Lys Lys Met Tyr 
    530                 535                 540                 


Tyr Asn Cys Ser Cys Ile Lys Glu Gly Leu Ile Thr Ala Asp Ala Glu 
545                 550                 555                 560 


Gly Asp Phe Ile Asp Ala Arg Pro Gly Lys Cys Asp Ala Lys Cys Tyr 
                565                 570                 575     


Lys Leu Pro Leu Phe Ile Ala Phe Ile Phe Ser Thr Leu Ile Phe Ser 
            580                 585                 590         


Gly Phe Ser Gly Val Pro Ile Val Leu Ala Met Thr Arg Val Val Pro 
        595                 600                 605             


Asp Lys Leu Arg Ser Leu Ala Leu Gly Val Ser Tyr Val Ile Leu Arg 
    610                 615                 620                 


Ile Phe Gly Thr Ile Pro Gly Pro Ser Ile Phe Lys Met Ser Gly Glu 
625                 630                 635                 640 


Thr Ser Cys Ile Leu Arg Asp Val Asn Lys Cys Gly His Thr Gly Arg 
                645                 650                 655     


Cys Trp Ile Tyr Asn Lys Thr Lys Met Ala Phe Leu Leu Val Gly Ile 
            660                 665                 670         


Cys Phe Leu Cys Lys Leu Cys Thr Ile Ile Phe Thr Thr Ile Ala Phe 
        675                 680                 685             


Phe Ile Tyr Lys Arg Arg Leu Asn Glu Asn Thr Asp Phe Pro Asp Val 
    690                 695                 700                 


Thr Val Lys Asn Pro Lys Val Lys Lys Lys Glu Glu Thr Asp Leu 
705                 710                 715                 


<210>  6346
<211>  324
<212>  PRT
<213>  Homo sapiens

<400>  6346

Met Ser Pro Ala Ala Ala Ala Glu Pro Asp Gly Asp Gln Gln Asp Arg 
1               5                   10                  15      


His Val Ser Lys Leu Ile Phe Cys Phe Phe Val Phe Gly Ala Val Leu 
            20                  25                  30          


Leu Cys Val Gly Val Leu Leu Ser Ile Phe Gly Phe Gln Ala Cys Gln 
        35                  40                  45              


Tyr Lys Pro Leu Pro Asp Cys Pro Met Val Leu Lys Val Ala Gly Pro 
    50                  55                  60                  


Ala Cys Ala Val Val Gly Leu Gly Ala Val Ile Leu Ala Arg Ser Arg 
65                  70                  75                  80  


Ala Gln Leu Gln Leu Arg Ala Gly Leu Gln Arg Gly Gln Gln Met Asp 
                85                  90                  95      


Pro Asp Arg Ala Phe Ile Cys Gly Glu Ser Arg Gln Phe Ala Gln Cys 
            100                 105                 110         


Leu Ile Phe Gly Phe Leu Phe Leu Thr Ser Gly Met Leu Ile Ser Val 
        115                 120                 125             


Leu Gly Ile Trp Val Pro Gly Cys Gly Ser Asn Trp Ala Gln Glu Pro 
    130                 135                 140                 


Leu Asn Glu Thr Asp Thr Gly Asp Ser Glu Pro Arg Met Cys Gly Phe 
145                 150                 155                 160 


Leu Ser Leu Gln Ile Met Gly Pro Leu Ile Val Leu Val Gly Leu Cys 
                165                 170                 175     


Phe Phe Val Val Ala His Val Lys Lys Arg Asn Thr Leu Asn Ala Gly 
            180                 185                 190         


Gln Asp Ala Ser Glu Arg Glu Glu Gly Gln Ile Gln Ile Met Glu Pro 
        195                 200                 205             


Val Gln Val Thr Val Gly Asp Ser Val Ile Ile Phe Pro Pro Pro Pro 
    210                 215                 220                 


Pro Pro Tyr Phe Pro Glu Ser Ser Ala Ser Ala Val Ala Glu Ser Pro 
225                 230                 235                 240 


Gly Thr Asn Ser Leu Leu Pro Asn Glu Asn Pro Pro Ser Tyr Tyr Ser 
                245                 250                 255     


Ile Phe Asn Tyr Gly Arg Thr Pro Thr Ser Glu Gly Ala Ala Ser Glu 
            260                 265                 270         


Arg Asp Cys Glu Ser Ile Tyr Thr Ile Ser Gly Thr Asn Ser Ser Ser 
        275                 280                 285             


Glu Ala Ser His Thr Pro His Leu Pro Ser Glu Leu Pro Pro Arg Tyr 
    290                 295                 300                 


Glu Glu Lys Glu Asn Ala Ala Ala Thr Phe Leu Pro Leu Ser Ser Glu 
305                 310                 315                 320 


Pro Ser Pro Pro 
                


<210>  6347
<211>  888
<212>  PRT
<213>  Homo sapiens

<400>  6347

Met Leu Arg Gln Val Leu His Arg Gly Leu Arg Thr Cys Phe Ser Arg 
1               5                   10                  15      


Leu Gly His Phe Ile Ala Ser His Pro Val Phe Phe Ala Ser Ala Pro 
            20                  25                  30          


Val Leu Ile Ser Ile Leu Leu Gly Ala Ser Phe Ser Arg Tyr Gln Val 
        35                  40                  45              


Glu Glu Ser Val Glu His Leu Leu Ala Pro Gln His Ser Leu Ala Lys 
    50                  55                  60                  


Ile Glu Arg Asn Leu Val Asn Ser Leu Phe Pro Val Asn Arg Ser Lys 
65                  70                  75                  80  


His Arg Leu Tyr Ser Asp Leu Gln Thr Pro Gly Arg Tyr Gly Arg Val 
                85                  90                  95      


Ile Val Thr Ser Phe Gln Lys Ala Asn Met Leu Asp Gln His His Thr 
            100                 105                 110         


Asp Leu Ile Leu Lys Leu His Ala Ala Val Thr Lys Ile Gln Val Pro 
        115                 120                 125             


Arg Pro Gly Phe Asn Tyr Thr Phe Ala His Ile Cys Ile Leu Asn Asn 
    130                 135                 140                 


Asp Lys Thr Cys Ile Val Asp Asp Ile Val His Val Leu Glu Glu Leu 
145                 150                 155                 160 


Lys Asn Ala Arg Ala Thr Asn Arg Thr Asn Phe Ala Ile Thr Tyr Pro 
                165                 170                 175     


Ile Thr His Leu Lys Asp Gly Arg Ala Val Tyr Asn Gly His Gln Leu 
            180                 185                 190         


Gly Gly Val Thr Val His Ser Lys Asp Arg Val Lys Ser Ala Glu Ala 
        195                 200                 205             


Ile Gln Leu Thr Tyr Tyr Leu Gln Ser Ile Asn Ser Leu Asn Asp Met 
    210                 215                 220                 


Val Ala Glu Arg Trp Glu Ser Ser Phe Cys Asp Thr Val Arg Leu Phe 
225                 230                 235                 240 


Gln Lys Ser Asn Ser Lys Val Lys Met Tyr Pro Tyr Thr Ser Ser Ser 
                245                 250                 255     


Leu Arg Glu Asp Phe Gln Lys Thr Ser Arg Val Ser Glu Arg Tyr Leu 
            260                 265                 270         


Val Thr Ser Leu Ile Leu Val Val Thr Met Ala Ile Leu Cys Cys Ser 
        275                 280                 285             


Met Gln Asp Cys Val Arg Ser Lys Pro Trp Leu Gly Leu Leu Gly Leu 
    290                 295                 300                 


Val Thr Ile Ser Leu Ala Thr Leu Thr Ala Ala Gly Ile Ile Asn Leu 
305                 310                 315                 320 


Thr Gly Gly Lys Tyr Asn Ser Thr Phe Leu Gly Val Pro Phe Val Met 
                325                 330                 335     


Leu Gly His Gly Leu Tyr Gly Thr Phe Glu Met Leu Ser Ser Trp Arg 
            340                 345                 350         


Lys Thr Arg Glu Asp Gln His Val Lys Glu Arg Thr Ala Ala Val Tyr 
        355                 360                 365             


Ala Asp Ser Met Leu Ser Phe Ser Leu Thr Thr Ala Met Tyr Leu Val 
    370                 375                 380                 


Thr Phe Gly Ile Gly Ala Ser Pro Phe Thr Asn Ile Glu Ala Ala Arg 
385                 390                 395                 400 


Ile Phe Cys Cys Asn Ser Cys Ile Ala Ile Phe Phe Asn Tyr Leu Tyr 
                405                 410                 415     


Val Leu Ser Phe Tyr Gly Ser Ser Leu Val Phe Thr Gly Tyr Ile Glu 
            420                 425                 430         


Asn Asn Tyr Gln His Ser Ile Phe Cys Arg Lys Val Pro Lys Pro Glu 
        435                 440                 445             


Ala Leu Gln Glu Lys Pro Ala Trp Tyr Arg Phe Leu Leu Thr Ala Arg 
    450                 455                 460                 


Phe Ser Glu Asp Thr Ala Glu Gly Glu Glu Ala Asn Thr Tyr Glu Ser 
465                 470                 475                 480 


His Leu Leu Val Cys Phe Leu Lys Arg Tyr Tyr Cys Asp Trp Ile Thr 
                485                 490                 495     


Asn Thr Tyr Val Lys Pro Phe Val Val Leu Phe Tyr Leu Ile Tyr Ile 
            500                 505                 510         


Ser Phe Ala Leu Met Gly Tyr Leu Gln Val Ser Glu Gly Ser Asp Leu 
        515                 520                 525             


Ser Asn Ile Val Ala Thr Ala Thr Gln Thr Ile Glu Tyr Thr Thr Ala 
    530                 535                 540                 


Gln Gln Lys Tyr Phe Ser Asn Tyr Ser Pro Val Ile Gly Phe Tyr Ile 
545                 550                 555                 560 


Tyr Glu Ser Ile Glu Tyr Trp Asn Thr Ser Val Gln Glu Asp Val Leu 
                565                 570                 575     


Glu Tyr Thr Lys Gly Phe Val Arg Ile Ser Trp Phe Glu Ser Tyr Leu 
            580                 585                 590         


Asn Tyr Leu Arg Lys Leu Asn Val Ser Thr Gly Leu Pro Lys Lys Asn 
        595                 600                 605             


Phe Thr Asp Met Leu Arg Asn Ser Phe Leu Lys Ala Pro Gln Phe Ser 
    610                 615                 620                 


His Phe Gln Glu Asp Ile Ile Phe Ser Lys Lys Tyr Asn Asp Glu Val 
625                 630                 635                 640 


Asp Val Val Ala Ser Arg Met Phe Leu Val Ala Lys Thr Met Glu Thr 
                645                 650                 655     


Asn Arg Glu Glu Leu Tyr Asp Leu Leu Glu Thr Leu Arg Arg Leu Ser 
            660                 665                 670         


Val Thr Ser Lys Val Lys Phe Ile Val Phe Asn Pro Ser Phe Val Tyr 
        675                 680                 685             


Met Asp Arg Tyr Ala Ser Ser Leu Gly Ala Pro Leu His Asn Ser Cys 
    690                 695                 700                 


Ile Ser Ala Leu Phe Leu Leu Phe Phe Ser Ala Phe Leu Val Ala Asp 
705                 710                 715                 720 


Ser Leu Ile Asn Val Trp Ile Thr Leu Thr Val Val Ser Val Glu Phe 
                725                 730                 735     


Gly Val Ile Gly Phe Met Thr Leu Trp Lys Val Glu Leu Asp Cys Ile 
            740                 745                 750         


Ser Val Leu Cys Leu Ile Tyr Gly Ile Asn Tyr Thr Ile Asp Asn Cys 
        755                 760                 765             


Ala Pro Met Leu Ser Thr Phe Val Leu Gly Lys Asp Phe Thr Arg Thr 
    770                 775                 780                 


Lys Trp Val Lys Asn Ala Leu Glu Val His Gly Val Ala Ile Leu Gln 
785                 790                 795                 800 


Ser Tyr Leu Cys Tyr Ile Val Gly Leu Ile Pro Leu Ala Ala Val Pro 
                805                 810                 815     


Ser Asn Leu Thr Cys Thr Leu Phe Arg Cys Leu Phe Leu Ile Ala Phe 
            820                 825                 830         


Val Thr Phe Phe His Cys Phe Ala Ile Leu Pro Val Ile Leu Thr Phe 
        835                 840                 845             


Leu Pro Pro Ser Lys Lys Lys Arg Lys Glu Lys Lys Asn Pro Glu Asn 
    850                 855                 860                 


Arg Glu Glu Ile Glu Cys Val Glu Met Val Asp Ile Asp Ser Thr Arg 
865                 870                 875                 880 


Val Val Asp Gln Ile Thr Thr Val 
                885             


<210>  6348
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  6348

Met Cys Arg Met Ser Phe Lys Lys Glu Thr Pro Leu Ala Asn Ala Ala 
1               5                   10                  15      


Phe Trp Ala Ala Arg Arg Gly Asn Leu Ala Leu Leu Lys Leu Leu Leu 
            20                  25                  30          


Asn Ser Gly Arg Val Asp Val Asp Cys Arg Asp Ser His Gly Thr Thr 
        35                  40                  45              


Leu Leu Met Val Ala Ala Tyr Ala Gly His Ile Asp Cys Val Arg Glu 
    50                  55                  60                  


Leu Val Leu Gln Gly Ala Asp Ile Asn Leu Gln Arg Glu Ser Gly Thr 
65                  70                  75                  80  


Thr Ala Leu Phe Phe Ala Ala Gln Gln Gly His Asn Asp Val Val Arg 
                85                  90                  95      


Phe Leu Phe Gly Phe Gly Ala Ser Thr Glu Phe Arg Thr Lys Asp Gly 
            100                 105                 110         


Gly Thr Ala Leu Leu Ala Ala Ser Gln Tyr Gly His Met Gln Val Val 
        115                 120                 125             


Glu Thr Leu Leu Lys His Gly Ala Asn Ile His Asp Gln Leu Tyr Asp 
    130                 135                 140                 


Gly Ala Thr Ala Leu Phe Leu Ala Ala Gln Gly Gly Tyr Leu Asp Val 
145                 150                 155                 160 


Ile Arg Leu Leu Leu Ala Ser Gly Ala Lys Val Asn Gln Pro Arg Gln 
                165                 170                 175     


Asp Gly Thr Ala Pro Leu Trp Ile Ala Ser Gln Met Gly His Ser Glu 
            180                 185                 190         


Val Val Arg Val Met Leu Leu Arg Gly Ala Asp Arg Asp Ala Ala Arg 
        195                 200                 205             


Asn Asp Gly Thr Thr Ala Leu Leu Lys Ala Ala Asn Lys Gly Tyr Asn 
    210                 215                 220                 


Asp Val Ile Lys Glu Leu Leu Lys Phe Ser Pro Thr Leu Gly Ile Leu 
225                 230                 235                 240 


Lys Asn Gly Thr Ser Ala Leu His Ala Ala Val Leu Ser Gly Asn Ile 
                245                 250                 255     


Lys Thr Val Ala Leu Leu Leu Glu Ala Gly Ala Asp Pro Ser Leu Arg 
            260                 265                 270         


Asn Lys Ala Asn Glu Leu Pro Ala Glu Leu Thr Lys Asn Glu Arg Ile 
        275                 280                 285             


Leu Arg Leu Leu Arg Ser Lys Glu Gly Pro Arg Lys Ser 
    290                 295                 300     


<210>  6349
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  6349

Met Thr Ala Gly Thr Val Val Ile Thr Gly Gly Ile Leu Ala Thr Val 
1               5                   10                  15      


Ile Leu Leu Cys Ile Ile Ala Val Leu Cys Tyr Cys Arg Leu Gln Tyr 
            20                  25                  30          


Tyr Cys Cys Lys Lys Ser Gly Thr Glu Val Ala Asp Glu Glu Glu Glu 
        35                  40                  45              


Arg Glu His Asp Leu Pro Thr His Pro Arg Gly Pro Thr Cys Asn Ala 
    50                  55                  60                  


Cys Ser Ser Gln Ala Leu Asp Gly Arg Gly Ser Leu Ala Pro Leu Thr 
65                  70                  75                  80  


Ser Glu Pro Cys Ser Gln Pro Cys Gly Val Ala Ala Ser His Cys Thr 
                85                  90                  95      


Thr Cys Ser Pro Tyr Ser Ser Pro Phe Tyr Ile Arg Thr Ala Asp Met 
            100                 105                 110         


Val Pro Asn Gly Gly Gly Gly Glu Arg Leu Ser Phe Ala Pro Thr Tyr 
        115                 120                 125             


Tyr Lys Glu Gly Gly Pro Pro Ser Leu Lys Leu Ala Ala Pro Gln Ser 
    130                 135                 140                 


Tyr Pro Val Thr Trp Pro Gly Ser Gly Arg Glu Ala Phe Thr Asn Pro 
145                 150                 155                 160 


Arg Ala Ile Ser Thr Asp Val 
                165         


<210>  6350
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  6350

Met Lys Gln Ala Gly Phe Pro Leu Gly Ile Leu Leu Leu Phe Trp Val 
1               5                   10                  15      


Ser Tyr Val Thr Asp Phe Ser Leu Val Leu Leu Ile Lys Gly Gly Ala 
            20                  25                  30          


Leu Ser Gly Thr Asp Thr Tyr Gln Ser Leu Val Asn Lys Thr Phe Gly 
        35                  40                  45              


Phe Pro Gly Tyr Leu Leu Leu Ser Val Leu Gln Phe Leu Tyr Pro Phe 
    50                  55                  60                  


Ile Val Asp Pro Glu Asn Val Phe Ile Gly Arg His Phe Ile Ile Gly 
65                  70                  75                  80  


Leu Ser Thr Val Thr Phe Thr Leu Pro Leu Ser Leu Tyr Arg Asn Ile 
                85                  90                  95      


Ala Lys Leu Gly Lys Val Ser Leu Ile Ser Thr Gly Leu Thr Thr Leu 
            100                 105                 110         


Ile Leu Gly Ile Val Met Ala Arg Ala Ile Ser Leu Gly Pro His Ile 
        115                 120                 125             


Pro Lys Thr Glu Asp Ala Trp Val Phe Ala Lys Pro Asn Ala Ile Gln 
    130                 135                 140                 


Ala Val Gly Val Met Ser Phe Ala Phe Ile Cys His His Asn Ser Phe 
145                 150                 155                 160 


Leu Val Tyr Ser Ser Leu Glu Glu Pro Thr Val Ala Lys Trp Ser Arg 
                165                 170                 175     


Leu Ile His Met Ser Ile Val Ile Ser Val Phe Ile Cys Ile Phe Phe 
            180                 185                 190         


Ala Thr Cys Gly Tyr Leu Thr Phe Thr Gly Phe Thr Gln Gly Asp Leu 
        195                 200                 205             


Phe Glu Asn Tyr Cys Arg Asn Asp Asp Leu Val Thr Phe Gly Arg Phe 
    210                 215                 220                 


Cys Tyr Gly Val Thr Val Ile Leu Thr Tyr Pro Met Glu Cys Phe Val 
225                 230                 235                 240 


Thr Arg Glu Val Ile Ala Asn Val Phe Phe Gly Gly Asn Leu Ser Ser 
                245                 250                 255     


Val Phe His Ile Val Val Thr Val Met Val Ile Thr Val Ala Thr Leu 
            260                 265                 270         


Val Ser Leu Leu Ile Asp Cys Leu Gly Ile Val Leu Glu Leu Asn Gly 
        275                 280                 285             


Val Leu Cys Ala Thr Pro Leu Ile Phe Ile Ile Pro Ser Ala Cys Tyr 
    290                 295                 300                 


Leu Lys Leu Ser Glu Glu Pro Arg Thr His Ser Asp Lys Ile Met Ser 
305                 310                 315                 320 


Cys Val Met Leu Pro Ile Gly Ala Val Val Met Val Phe Gly Phe Val 
                325                 330                 335     


Met Ala Ile Thr Asn Thr Gln Asp Cys Thr His Gly Gln Glu Met Phe 
            340                 345                 350         


Tyr Cys Phe Pro Asp Asn Phe Ser Leu Thr Asn Thr Ser Glu Ser His 
        355                 360                 365             


Val Gln Gln Thr Thr Gln Leu Ser Thr Leu Asn Ile Ser Ile Phe Gln 
    370                 375                 380                 


<210>  6351
<211>  561
<212>  PRT
<213>  Homo sapiens

<400>  6351

Met Ala Asn Met Asn Ser Asp Ser Arg His Leu Gly Thr Ser Glu Val 
1               5                   10                  15      


Asp His Glu Arg Asp Pro Gly Pro Met Asn Ile Gln Phe Glu Pro Ser 
            20                  25                  30          


Asp Leu Arg Ser Lys Arg Pro Phe Cys Ile Glu Pro Thr Asn Ile Val 
        35                  40                  45              


Asn Val Asn His Val Ile Gln Arg Val Ser Asp His Ala Ser Ala Met 
    50                  55                  60                  


Asn Lys Arg Ile His Tyr Tyr Ser Arg Leu Thr Thr Pro Ala Asp Lys 
65                  70                  75                  80  


Ala Leu Ile Ala Pro Asp His Val Val Pro Ala Pro Glu Glu Cys Tyr 
                85                  90                  95      


Val Tyr Ser Pro Leu Gly Ser Ala Tyr Lys Leu Gln Ser Tyr Thr Glu 
            100                 105                 110         


Gly Tyr Gly Lys Asn Thr Ser Leu Val Thr Ile Phe Met Ile Trp Asn 
        115                 120                 125             


Thr Met Met Gly Thr Ser Ile Leu Ser Ile Pro Trp Gly Ile Lys Gln 
    130                 135                 140                 


Ala Gly Phe Thr Thr Gly Met Cys Val Ile Ile Leu Met Gly Leu Leu 
145                 150                 155                 160 


Thr Leu Tyr Cys Cys Tyr Arg Val Val Lys Ser Arg Thr Met Met Phe 
                165                 170                 175     


Ser Leu Asp Thr Thr Ser Trp Glu Tyr Pro Asp Val Cys Arg His Tyr 
            180                 185                 190         


Phe Gly Ser Phe Gly Gln Trp Ser Ser Leu Leu Phe Ser Leu Val Ser 
        195                 200                 205             


Leu Ile Gly Ala Met Ile Val Tyr Trp Val Leu Met Ser Asn Phe Leu 
    210                 215                 220                 


Phe Asn Thr Gly Lys Phe Ile Phe Asn Phe Ile His His Ile Asn Asp 
225                 230                 235                 240 


Thr Asp Thr Ile Leu Ser Thr Asn Asn Ser Asn Pro Val Ile Cys Pro 
                245                 250                 255     


Ser Ala Gly Ser Gly Gly His Pro Asp Asn Ser Ser Met Ile Phe Tyr 
            260                 265                 270         


Ala Asn Asp Thr Gly Ala Gln Gln Phe Glu Lys Trp Trp Asp Lys Ser 
        275                 280                 285             


Arg Thr Val Pro Phe Tyr Leu Val Gly Leu Leu Leu Pro Leu Leu Asn 
    290                 295                 300                 


Phe Lys Ser Pro Ser Phe Phe Ser Lys Phe Asn Ile Leu Gly Thr Val 
305                 310                 315                 320 


Ser Val Leu Tyr Leu Ile Phe Leu Val Thr Phe Lys Ala Val Arg Leu 
                325                 330                 335     


Gly Phe His Leu Glu Phe His Trp Phe Ile Pro Thr Glu Phe Phe Val 
            340                 345                 350         


Pro Glu Ile Arg Phe Gln Phe Pro Gln Leu Thr Gly Val Leu Thr Leu 
        355                 360                 365             


Ala Phe Phe Ile His Asn Cys Ile Ile Thr Leu Leu Lys Asn Asn Lys 
    370                 375                 380                 


Lys Gln Glu Asn Asn Val Arg Asp Leu Cys Ile Ala Tyr Met Leu Val 
385                 390                 395                 400 


Thr Leu Thr Tyr Leu Tyr Ile Gly Val Leu Val Phe Ala Ser Phe Pro 
                405                 410                 415     


Ser Pro Pro Leu Ser Lys Asp Cys Ile Glu Gln Asn Phe Leu Asp Asn 
            420                 425                 430         


Phe Pro Ser Ser Asp Thr Leu Ser Phe Ile Ala Arg Ile Phe Leu Leu 
        435                 440                 445             


Phe Gln Met Met Thr Val Tyr Pro Leu Leu Gly Tyr Leu Ala Arg Val 
    450                 455                 460                 


Gln Leu Leu Gly His Ile Phe Gly Asp Ile Tyr Pro Ser Ile Phe His 
465                 470                 475                 480 


Val Leu Ile Leu Asn Leu Ile Ile Val Gly Ala Gly Val Ile Met Ala 
                485                 490                 495     


Cys Phe Tyr Pro Asn Ile Gly Gly Ile Ile Arg Tyr Ser Gly Ala Ala 
            500                 505                 510         


Cys Gly Leu Ala Phe Val Phe Ile Tyr Pro Ser Leu Ile Tyr Ile Ile 
        515                 520                 525             


Ser Leu His Gln Glu Glu Arg Leu Thr Trp Pro Lys Leu Ile Phe His 
    530                 535                 540                 


Val Phe Ile Ile Ile Leu Gly Val Ala Asn Leu Ile Val Gln Phe Phe 
545                 550                 555                 560 


Met 
    


<210>  6352
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  6352

Met Ala Ala Pro Val Leu Leu Arg Val Ser Val Pro Arg Trp Glu Arg 
1               5                   10                  15      


Val Ala Arg Tyr Ala Val Cys Ala Ala Gly Ile Leu Leu Ser Ile Tyr 
            20                  25                  30          


Ala Tyr His Val Glu Arg Glu Lys Glu Arg Asp Pro Glu His Arg Ala 
        35                  40                  45              


Leu Cys Asp Leu Gly Pro Trp Val Lys Cys Ser Ala Ala Leu Ala Ser 
    50                  55                  60                  


Arg Trp Gly Arg Gly Phe Gly Leu Leu Gly Ser Ile Phe Gly Lys Asp 
65                  70                  75                  80  


Gly Val Leu Asn Gln Pro Asn Ser Val Phe Gly Leu Ile Phe Tyr Ile 
                85                  90                  95      


Leu Gln Leu Leu Leu Gly Met Thr Ala Ser Ala Val Ala Ala Leu Ile 
            100                 105                 110         


Leu Met Thr Ser Ser Ile Met Ser Val Val Gly Ser Leu Tyr Leu Ala 
        115                 120                 125             


Tyr Ile Leu Tyr Phe Val Leu Lys Glu Phe Cys Ile Ile Cys Ile Val 
    130                 135                 140                 


Thr Tyr Val Leu Asn Phe Leu Leu Leu Ile Ile Asn Tyr Lys Arg Leu 
145                 150                 155                 160 


Val Tyr Leu Asn Glu Ala Trp Lys Arg Gln Leu Gln Pro Lys Gln Asp 
                165                 170                 175     


<210>  6353
<211>  589
<212>  PRT
<213>  Homo sapiens

<400>  6353

Met Asp Gly Glu Ala Val Arg Phe Cys Thr Asp Asn Gln Cys Val Ser 
1               5                   10                  15      


Leu His Pro Gln Glu Val Asp Ser Val Ala Met Ala Pro Ala Ala Pro 
            20                  25                  30          


Lys Ile Pro Arg Leu Val Gln Ala Thr Pro Ala Phe Met Ala Val Thr 
        35                  40                  45              


Leu Val Phe Ser Leu Val Thr Leu Phe Val Val Val Gln Gln Gln Thr 
    50                  55                  60                  


Arg Pro Val Pro Lys Pro Val Gln Ala Val Ile Leu Gly Asp Asn Ile 
65                  70                  75                  80  


Thr Gly His Leu Pro Phe Glu Pro Asn Asn His His His Phe Gly Arg 
                85                  90                  95      


Glu Ala Glu Met Arg Glu Leu Ile Gln Thr Phe Lys Gly His Met Glu 
            100                 105                 110         


Asn Ser Ser Ala Trp Val Val Glu Ile Gln Met Leu Lys Cys Arg Val 
        115                 120                 125             


Asp Asn Val Asn Ser Gln Leu Gln Val Leu Gly Asp His Leu Gly Asn 
    130                 135                 140                 


Thr Asn Ala Asp Ile Gln Met Val Lys Gly Val Leu Lys Asp Ala Thr 
145                 150                 155                 160 


Thr Leu Ser Leu Gln Thr Gln Met Leu Arg Ser Ser Leu Glu Gly Thr 
                165                 170                 175     


Asn Ala Glu Ile Gln Arg Leu Lys Glu Asp Leu Glu Lys Ala Asp Ala 
            180                 185                 190         


Leu Thr Phe Gln Thr Leu Asn Phe Leu Lys Ser Ser Leu Glu Asn Thr 
        195                 200                 205             


Ser Ile Glu Leu His Val Leu Ser Arg Gly Leu Glu Asn Ala Asn Ser 
    210                 215                 220                 


Glu Ile Gln Met Leu Asn Ala Ser Leu Glu Thr Ala Asn Thr Gln Ala 
225                 230                 235                 240 


Gln Leu Ala Asn Ser Ser Leu Lys Asn Ala Asn Ala Glu Ile Tyr Val 
                245                 250                 255     


Leu Arg Gly His Leu Asp Ser Val Asn Asp Leu Arg Thr Gln Asn Gln 
            260                 265                 270         


Val Leu Arg Asn Ser Leu Glu Gly Ala Asn Ala Glu Ile Gln Gly Leu 
        275                 280                 285             


Lys Glu Asn Leu Gln Asn Thr Asn Ala Leu Asn Ser Gln Thr Gln Ala 
    290                 295                 300                 


Phe Ile Lys Ser Ser Phe Asp Asn Thr Ser Ala Glu Ile Gln Phe Leu 
305                 310                 315                 320 


Arg Gly His Leu Glu Arg Ala Gly Asp Glu Ile His Val Leu Lys Arg 
                325                 330                 335     


Asp Leu Lys Met Val Thr Ala Gln Thr Gln Lys Ala Asn Gly Arg Leu 
            340                 345                 350         


Asp Gln Thr Asp Thr Gln Ile Gln Val Phe Lys Ser Glu Met Glu Asn 
        355                 360                 365             


Val Asn Thr Leu Asn Ala Gln Ile Gln Val Leu Asn Gly His Met Lys 
    370                 375                 380                 


Asn Ala Ser Arg Glu Ile Gln Thr Leu Lys Gln Gly Met Lys Asn Ala 
385                 390                 395                 400 


Ser Ala Leu Thr Ser Gln Thr Gln Met Leu Asp Ser Asn Leu Gln Lys 
                405                 410                 415     


Ala Ser Ala Glu Ile Gln Arg Leu Arg Gly Asp Leu Glu Asn Thr Lys 
            420                 425                 430         


Ala Leu Thr Met Glu Ile Gln Gln Glu Gln Ser Arg Leu Lys Thr Leu 
        435                 440                 445             


His Val Val Ile Thr Ser Gln Glu Gln Leu Gln Arg Thr Gln Ser Gln 
    450                 455                 460                 


Leu Leu Gln Met Val Leu Gln Gly Trp Lys Phe Asn Gly Gly Ser Leu 
465                 470                 475                 480 


Tyr Tyr Phe Ser Ser Val Lys Lys Ser Trp His Glu Ala Glu Gln Phe 
                485                 490                 495     


Cys Val Ser Gln Gly Ala His Leu Ala Ser Val Ala Ser Lys Glu Glu 
            500                 505                 510         


Gln Ala Phe Leu Val Glu Phe Thr Ser Lys Val Tyr Tyr Trp Ile Gly 
        515                 520                 525             


Leu Thr Asp Arg Gly Thr Glu Gly Ser Trp Arg Trp Thr Asp Gly Thr 
    530                 535                 540                 


Pro Phe Asn Ala Ala Gln Asn Lys Ala Pro Gly Ser Lys Gly Ser Cys 
545                 550                 555                 560 


Pro Leu Arg Lys Tyr Ile Ile Val Asn Ser Gly Met Gly Ala Cys Ser 
                565                 570                 575     


Phe Ile Asp Thr Pro Pro Cys Pro Trp Ile Leu Ser Asn 
            580                 585                 


<210>  6354
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  6354

Met Gly Pro Leu Lys Ala Phe Leu Phe Ser Pro Phe Leu Leu Arg Ser 
1               5                   10                  15      


Gln Ser Arg Gly Val Arg Leu Val Phe Leu Leu Leu Thr Leu His Leu 
            20                  25                  30          


Gly Asn Cys Val Asp Lys Ala Asp Asp Glu Asp Asp Glu Asp Leu Thr 
        35                  40                  45              


Val Asn Lys Thr Trp Val Leu Ala Pro Lys Ile His Glu Gly Asp Ile 
    50                  55                  60                  


Thr Gln Ile Leu Asn Ser Leu Leu Gln Gly Tyr Asp Asn Lys Leu Arg 
65                  70                  75                  80  


Pro Asp Ile Gly Val Arg Pro Thr Val Ile Glu Thr Asp Val Tyr Val 
                85                  90                  95      


Asn Ser Ile Gly Pro Val Asp Pro Ile Asn Met Glu Tyr Thr Ile Asp 
            100                 105                 110         


Ile Ile Phe Ala Gln Thr Trp Phe Asp Ser Arg Leu Lys Phe Asn Ser 
        115                 120                 125             


Thr Met Lys Val Leu Met Leu Asn Ser Asn Met Val Gly Lys Ile Trp 
    130                 135                 140                 


Ile Pro Asp Thr Phe Phe Arg Asn Ser Arg Lys Ser Asp Ala His Trp 
145                 150                 155                 160 


Ile Thr Thr Pro Asn Arg Leu Leu Arg Ile Trp Asn Asp Gly Arg Val 
                165                 170                 175     


Leu Tyr Thr Leu Arg Leu Thr Ile Asn Ala Glu Cys Tyr Leu Gln Leu 
            180                 185                 190         


His Asn Phe Pro Met Asp Glu His Ser Cys Pro Leu Glu Phe Ser Ser 
        195                 200                 205             


Tyr Gly Tyr Pro Lys Asn Glu Ile Glu Tyr Lys Trp Lys Lys Pro Ser 
    210                 215                 220                 


Val Glu Val Ala Asp Pro Lys Tyr Trp Arg Leu Tyr Gln Phe Ala Phe 
225                 230                 235                 240 


Val Gly Leu Arg Asn Ser Thr Glu Ile Thr His Thr Ile Ser Gly Asp 
                245                 250                 255     


Tyr Val Ile Met Thr Ile Phe Phe Asp Leu Ser Arg Arg Met Gly Tyr 
            260                 265                 270         


Phe Thr Ile Gln Thr Tyr Ile Pro Cys Ile Leu Thr Val Val Leu Ser 
        275                 280                 285             


Trp Val Ser Phe Trp Ile Asn Lys Asp Ala Val Pro Ala Arg Thr Ser 
    290                 295                 300                 


Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr Leu Ser Thr Ile Ala 
305                 310                 315                 320 


Arg Lys Ser Leu Pro Lys Val Ser Tyr Val Thr Ala Met Asp Leu Phe 
                325                 330                 335     


Val Ser Val Cys Phe Ile Phe Val Phe Ala Ala Leu Met Glu Tyr Gly 
            340                 345                 350         


Thr Leu His Tyr Phe Thr Ser Asn Gln Lys Gly Lys Thr Ala Thr Lys 
        355                 360                 365             


Asp Arg Lys Leu Lys Asn Lys Ala Ser Met Thr Pro Gly Leu His Pro 
    370                 375                 380                 


Gly Ser Thr Leu Ile Pro Met Asn Asn Ile Ser Val Pro Gln Glu Asp 
385                 390                 395                 400 


Asp Tyr Gly Tyr Gln Cys Leu Glu Gly Lys Asp Cys Ala Ser Phe Phe 
                405                 410                 415     


Cys Cys Phe Glu Asp Cys Arg Thr Gly Ser Trp Arg Glu Gly Arg Ile 
            420                 425                 430         


His Ile Arg Ile Ala Lys Ile Asp Ser Tyr Ser Arg Ile Phe Phe Pro 
        435                 440                 445             


Thr Ala Phe Ala Leu Phe Asn Leu Val Tyr Trp Val Gly Tyr Leu Tyr 
    450                 455                 460                 


Leu 
465 


<210>  6355
<211>  589
<212>  PRT
<213>  Homo sapiens

<400>  6355

Met Val Gly Gln Met Tyr Cys Tyr Pro Gly Ser His Leu Ala Arg Ala 
1               5                   10                  15      


Leu Thr Arg Ala Leu Ala Leu Ala Leu Val Leu Ala Leu Leu Val Gly 
            20                  25                  30          


Pro Phe Leu Ser Gly Leu Ala Gly Ala Ile Pro Ala Pro Gly Gly Arg 
        35                  40                  45              


Trp Ala Arg Asp Gly Gln Val Pro Pro Ala Ser Arg Ser Arg Ser Val 
    50                  55                  60                  


Leu Leu Asp Val Ser Ala Gly Gln Leu Leu Met Val Asp Gly Arg His 
65                  70                  75                  80  


Pro Asp Ala Val Ala Trp Ala Asn Leu Thr Asn Ala Ile Arg Glu Thr 
                85                  90                  95      


Gly Trp Ala Phe Leu Glu Leu Gly Thr Ser Gly Gln Tyr Asn Asp Ser 
            100                 105                 110         


Leu Gln Ala Tyr Ala Ala Gly Val Val Glu Ala Ala Val Ser Glu Glu 
        115                 120                 125             


Leu Ile Tyr Met His Trp Met Asn Thr Val Val Asn Tyr Cys Gly Pro 
    130                 135                 140                 


Phe Glu Tyr Glu Val Gly Tyr Cys Glu Arg Leu Lys Ser Phe Leu Glu 
145                 150                 155                 160 


Ala Asn Leu Glu Trp Met Gln Glu Glu Met Glu Ser Asn Pro Asp Ser 
                165                 170                 175     


Pro Tyr Trp His Gln Val Arg Leu Thr Leu Leu Gln Leu Lys Gly Leu 
            180                 185                 190         


Glu Asp Ser Tyr Glu Gly Arg Val Ser Phe Pro Ala Gly Lys Phe Thr 
        195                 200                 205             


Ile Lys Pro Leu Gly Phe Leu Leu Leu Gln Leu Ser Gly Asp Leu Glu 
    210                 215                 220                 


Asp Leu Glu Leu Ala Leu Asn Lys Thr Lys Ile Lys Pro Ser Leu Gly 
225                 230                 235                 240 


Ser Gly Ser Cys Ser Ala Leu Ile Lys Leu Leu Pro Gly Gln Ser Asp 
                245                 250                 255     


Leu Leu Val Ala His Asn Thr Trp Asn Asn Tyr Gln His Met Leu Arg 
            260                 265                 270         


Val Ile Lys Lys Tyr Trp Leu Gln Phe Arg Glu Gly Pro Trp Gly Asp 
        275                 280                 285             


Tyr Pro Leu Val Pro Gly Asn Lys Leu Val Phe Ser Ser Tyr Pro Gly 
    290                 295                 300                 


Thr Ile Phe Ser Cys Asp Asp Phe Tyr Ile Leu Gly Ser Gly Leu Val 
305                 310                 315                 320 


Thr Leu Glu Thr Thr Ile Gly Asn Lys Asn Pro Ala Leu Trp Lys Tyr 
                325                 330                 335     


Val Arg Pro Arg Gly Cys Val Leu Glu Trp Val Arg Asn Ile Val Ala 
            340                 345                 350         


Asn Arg Leu Ala Ser Asp Gly Ala Thr Trp Ala Asp Ile Phe Lys Arg 
        355                 360                 365             


Phe Asn Ser Gly Thr Tyr Asn Asn Gln Trp Met Ile Val Asp Tyr Lys 
    370                 375                 380                 


Ala Phe Ile Pro Gly Gly Pro Ser Pro Gly Ser Arg Val Leu Thr Ile 
385                 390                 395                 400 


Leu Glu Gln Ile Pro Gly Met Val Val Val Ala Asp Lys Thr Ser Glu 
                405                 410                 415     


Leu Tyr Gln Lys Thr Tyr Trp Ala Ser Tyr Asn Ile Pro Ser Phe Glu 
            420                 425                 430         


Thr Val Phe Asn Ala Ser Gly Leu Gln Ala Leu Val Ala Gln Tyr Gly 
        435                 440                 445             


Asp Trp Phe Ser Tyr Asp Gly Ser Pro Arg Ala Gln Ile Phe Arg Arg 
    450                 455                 460                 


Asn Gln Ser Leu Val Gln Asp Met Asp Ser Met Val Arg Leu Met Arg 
465                 470                 475                 480 


Tyr Asn Asp Phe Leu His Asp Pro Leu Ser Leu Cys Lys Ala Cys Asn 
                485                 490                 495     


Pro Gln Pro Asn Gly Glu Asn Ala Ile Ser Ala Arg Ser Asp Leu Asn 
            500                 505                 510         


Pro Ala Asn Gly Ser Tyr Pro Phe Gln Ala Leu Arg Gln Arg Ser His 
        515                 520                 525             


Gly Gly Ile Asp Val Lys Val Thr Ser Met Ser Leu Ala Arg Ile Leu 
    530                 535                 540                 


Ser Leu Leu Ala Ala Ser Gly Pro Thr Trp Asp Gln Val Pro Pro Phe 
545                 550                 555                 560 


Gln Trp Ser Thr Ser Pro Phe Ser Gly Leu Leu His Met Gly Gln Pro 
                565                 570                 575     


Asp Leu Trp Lys Phe Ala Pro Val Lys Val Ser Trp Asp 
            580                 585                 


<210>  6356
<211>  511
<212>  PRT
<213>  Homo sapiens

<400>  6356

Met Ser Gly Gly Phe Glu Leu Gln Pro Arg Asp Gly Gly Pro Arg Val 
1               5                   10                  15      


Ala Leu Ala Pro Gly Glu Thr Val Ile Gly Arg Gly Pro Leu Leu Gly 
            20                  25                  30          


Ile Thr Asp Lys Arg Val Ser Arg Arg His Ala Ile Leu Glu Val Ala 
        35                  40                  45              


Gly Gly Gln Leu Arg Ile Lys Pro Ile His Thr Asn Pro Cys Phe Tyr 
    50                  55                  60                  


Gln Ser Ser Glu Lys Ser Gln Leu Leu Pro Leu Lys Pro Asn Leu Trp 
65                  70                  75                  80  


Cys Tyr Leu Asn Pro Gly Asp Ser Phe Ser Leu Leu Val Asp Lys Tyr 
                85                  90                  95      


Ile Phe Arg Ile Leu Ser Ile Pro Ser Glu Val Glu Met Gln Cys Thr 
            100                 105                 110         


Leu Arg Asn Ser Gln Val Leu Asp Glu Asp Asn Ile Leu Asn Glu Thr 
        115                 120                 125             


Pro Lys Ser Pro Val Ile Asn Leu Pro His Glu Thr Thr Gly Ala Ser 
    130                 135                 140                 


Gln Leu Glu Gly Ser Thr Glu Ile Ala Lys Thr Gln Met Thr Pro Thr 
145                 150                 155                 160 


Asn Ser Val Ser Phe Leu Gly Glu Asn Arg Asp Cys Asn Lys Gln Gln 
                165                 170                 175     


Pro Ile Leu Ala Glu Arg Lys Arg Ile Leu Pro Thr Trp Met Leu Ala 
            180                 185                 190         


Glu His Leu Ser Asp Gln Asn Leu Ser Val Pro Ala Ile Ser Gly Gly 
        195                 200                 205             


Asn Val Ile Gln Gly Ser Gly Lys Glu Glu Ile Cys Lys Asp Lys Ser 
    210                 215                 220                 


Gln Leu Asn Thr Thr Gln Gln Gly Arg Arg Gln Leu Ile Ser Ser Gly 
225                 230                 235                 240 


Ser Ser Glu Asn Thr Ser Ala Glu Gln Asp Thr Gly Glu Glu Cys Lys 
                245                 250                 255     


Asn Thr Asp Gln Glu Glu Ser Thr Ile Ser Ser Lys Glu Met Pro Gln 
            260                 265                 270         


Ser Phe Ser Ala Ile Thr Leu Ser Asn Thr Glu Met Asn Asn Ile Lys 
        275                 280                 285             


Thr Asn Ala Gln Arg Asn Lys Leu Pro Ile Glu Glu Leu Gly Lys Val 
    290                 295                 300                 


Ser Lys His Lys Ile Ala Thr Lys Arg Thr Pro His Lys Glu Asp Glu 
305                 310                 315                 320 


Ala Met Ser Cys Ser Glu Asn Cys Ser Ser Ala Gln Gly Asp Ser Leu 
                325                 330                 335     


Gln Asp Glu Ser Gln Gly Ser His Ser Glu Ser Ser Ser Asn Pro Ser 
            340                 345                 350         


Asn Pro Glu Thr Leu His Ala Lys Ala Thr Asp Ser Val Leu Gln Gly 
        355                 360                 365             


Ser Glu Gly Asn Lys Val Lys Arg Thr Ser Cys Met Tyr Gly Ala Asn 
    370                 375                 380                 


Cys Tyr Arg Lys Asn Pro Val His Phe Gln His Phe Ser His Pro Gly 
385                 390                 395                 400 


Asp Ser Asp Tyr Gly Gly Val Gln Ile Val Gly Gln Asp Glu Thr Asp 
                405                 410                 415     


Asp Arg Pro Glu Cys Pro Tyr Gly Pro Ser Cys Tyr Arg Lys Asn Pro 
            420                 425                 430         


Gln His Lys Ile Glu Tyr Arg His Asn Thr Leu Pro Val Arg Asn Val 
        435                 440                 445             


Leu Asp Glu Asp Asn Asp Asn Val Gly Gln Pro Asn Glu Tyr Asp Leu 
    450                 455                 460                 


Asn Asp Ser Phe Leu Asp Asp Glu Glu Glu Asp Tyr Glu Pro Thr Asp 
465                 470                 475                 480 


Glu Asp Ser Asp Trp Glu Pro Gly Lys Glu Asp Glu Glu Lys Glu Asp 
                485                 490                 495     


Val Glu Glu Leu Leu Lys Glu Ala Lys Arg Phe Met Lys Arg Lys 
            500                 505                 510     


<210>  6357
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  6357

Met Glu Thr Leu Ser Gln Asp Ser Leu Leu Glu Cys Gln Ile Cys Phe 
1               5                   10                  15      


Asn Tyr Tyr Ser Pro Arg Arg Arg Pro Lys Leu Leu Asp Cys Lys His 
            20                  25                  30          


Thr Cys Cys Ser Val Cys Leu Gln Gln Met Arg Thr Ser Gln Lys Asp 
        35                  40                  45              


Val Arg Cys Pro Trp Cys Arg Gly Val Thr Lys Leu Pro Pro Gly Phe 
    50                  55                  60                  


Ser Val Ser Gln Leu Pro Asp Asp Pro Glu Val Leu Ala Val Ile Ala 
65                  70                  75                  80  


Ile Pro His Thr Ser Glu His Thr Pro Val Phe Ile Lys Leu Pro Ser 
                85                  90                  95      


Asn Gly Cys Tyr Met Leu Pro Leu Pro Ile Ser Lys Glu Arg Ala Leu 
            100                 105                 110         


Leu Pro Gly Asp Met Gly Cys Arg Leu Leu Pro Gly Ser Gln Gln Lys 
        115                 120                 125             


Ser Val Thr Val Val Thr Ile Pro Ala Glu Gln Gln Pro Leu Gln Gly 
    130                 135                 140                 


Gly Ala Pro Gln Glu Ala Val Glu Glu Glu Gln Asp Arg Arg Gly Val 
145                 150                 155                 160 


Val Lys Ser Ser Thr Trp Ser Gly Val Cys Thr Val Ile Leu Val Ala 
                165                 170                 175     


Cys Val Leu Val Phe Leu Leu Gly Ile Val Leu His Asn Met Ser Cys 
            180                 185                 190         


Ile Ser Lys Arg Phe Thr Val Ile Ser Cys Gly 
        195                 200             


<210>  6358
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  6358

Met Cys Pro Gln Glu Ser Ser Phe Gln Pro Ser Gln Phe Leu Leu Leu 
1               5                   10                  15      


Val Gly Val Pro Val Ala Ser Val Leu Leu Leu Ala Gln Cys Leu Arg 
            20                  25                  30          


Trp His Cys Pro Arg Arg Leu Leu Gly Ala Cys Trp Thr Leu Asn Gly 
        35                  40                  45              


Gln Glu Glu Pro Val Ser Gln Pro Thr Pro Gln Leu Glu Asn Glu Val 
    50                  55                  60                  


Ser Arg Gln His Leu Pro Ala Thr Leu Pro Glu Met Val Ala Phe Tyr 
65                  70                  75                  80  


Gln Glu Leu His Thr Pro Thr Gln Gly Gln Thr Met Val Arg Gln Leu 
                85                  90                  95      


Met His Lys Leu Leu Val Phe Ser Ala Arg Glu Val Asp His Arg Gly 
            100                 105                 110         


Gly Cys Leu Met Leu Gln Asp Thr Gly Ile Ser Leu Leu Ile Pro Pro 
        115                 120                 125             


Gly Ala Val Ala Val Gly Arg Gln Glu Arg Val Ser Leu Ile Leu Val 
    130                 135                 140                 


Trp Asp Leu Ser Asp Ala Pro Ser Leu Ser Gln Ala Gln Gly Leu Val 
145                 150                 155                 160 


Ser Pro Val Val Ala Cys Gly Pro His Gly Ala Ser Phe Leu Lys Pro 
                165                 170                 175     


Cys Thr Leu Thr Phe Lys His Cys Ala Glu Gln Pro Ser His Ala Arg 
            180                 185                 190         


Thr Tyr Ser Ser Asn Thr Thr Leu Leu Asp Ala Lys Val Trp Arg Pro 
        195                 200                 205             


Leu Gly Arg Pro Gly Ala His Ala Ser Arg Asp Glu Cys Arg Ile His 
    210                 215                 220                 


Leu Ser His Phe Ser Leu Tyr Thr Cys Val Leu Glu Ala Pro Val Gly 
225                 230                 235                 240 


Arg Glu Ala Arg Lys Trp Leu Gln Leu Ala Val Phe Cys Ser Pro Leu 
                245                 250                 255     


Val Pro Gly Gln Ser His Leu Gln Leu Arg Ile Tyr Phe Leu Asn Asn 
            260                 265                 270         


Thr Pro Cys Ala Leu Gln Trp Ala Leu Thr Asn Glu Gln Pro His Gly 
        275                 280                 285             


Gly Arg Leu Arg Gly Pro Cys Gln Leu Phe Asp Phe Asn Gly Ala Arg 
    290                 295                 300                 


Gly Asp Gln Cys Leu Lys Leu Thr Tyr Ile Ser Glu Gly Trp Glu Asn 
305                 310                 315                 320 


Val Asp Asp Ser Ser Cys Gln Leu Val Pro His Leu His Ile Trp His 
                325                 330                 335     


Gly Lys Cys Pro Phe Arg Ser Phe Cys Phe Arg Arg Lys Ala Ala Asp 
            340                 345                 350         


Glu Asn Glu Asp Cys Ser Ala Leu Thr Asn Glu Ile Ile Val Thr Met 
        355                 360                 365             


His Thr Phe Gln Asp Gly Leu Glu Thr Lys Tyr Met Glu Ile Leu Arg 
    370                 375                 380                 


Phe Gln Ala Ser Glu Glu Glu Ser Trp Ala Ala Pro Pro Pro Val Ser 
385                 390                 395                 400 


Gln Pro Pro Pro Cys Asn Arg Leu Pro Pro Glu Leu Phe Glu Gln Leu 
                405                 410                 415     


Arg Met Leu Leu Glu Pro Asn Ser Ile Thr Gly Asn Asp Trp Arg Arg 
            420                 425                 430         


Leu Ala Ser His Leu Gly Leu Cys Gly Met Lys Ile Arg Phe Leu Ser 
        435                 440                 445             


Cys Gln Arg Ser Pro Ala Ala Ala Ile Leu Glu Leu Phe Glu Glu Gln 
    450                 455                 460                 


Asn Gly Ser Leu Gln Glu Leu His Tyr Leu Met Thr Val Met Glu Arg 
465                 470                 475                 480 


Leu Asp Cys Ala Ser Ala Ile Gln Asn Tyr Leu Ser Gly Thr His Gly 
                485                 490                 495     


Gly Ser Pro Gly Pro Glu Arg Gly Gly Ala Arg Asp Asn Gln Gly Leu 
            500                 505                 510         


Glu Leu Asp Glu Lys Leu 
        515             


<210>  6359
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  6359

Met Ala Arg Leu Arg Asp Cys Leu Pro Arg Leu Met Leu Thr Leu Arg 
1               5                   10                  15      


Ser Leu Leu Phe Trp Ser Leu Val Tyr Cys Tyr Cys Gly Leu Cys Ala 
            20                  25                  30          


Ser Ile His Leu Leu Lys Leu Leu Trp Ser Leu Gly Lys Gly Pro Ala 
        35                  40                  45              


Gln Thr Phe Arg Arg Pro Ala Arg Glu His Pro Pro Ala Cys Leu Ser 
    50                  55                  60                  


Asp Pro Ser Leu Gly Thr His Cys Tyr Val Arg Ile Lys Asp Ser Gly 
65                  70                  75                  80  


Leu Arg Phe His Tyr Val Ala Ala Gly Glu Arg Gly Lys Pro Leu Met 
                85                  90                  95      


Leu Leu Leu His Gly Phe Pro Glu Phe Trp Tyr Ser Trp Arg Tyr Gln 
            100                 105                 110         


Leu Arg Glu Phe Lys Ser Glu Tyr Arg Val Val Ala Leu Asp Leu Arg 
        115                 120                 125             


Gly Tyr Gly Glu Thr Asp Ala Pro Ile His Arg Gln Asn Tyr Lys Leu 
    130                 135                 140                 


Asp Cys Leu Ile Thr Asp Ile Lys Asp Ile Leu Asp Ser Leu Gly Tyr 
145                 150                 155                 160 


Ser Lys Cys Val Leu Ile Gly His Asp Trp Gly Gly Met Ile Ala Trp 
                165                 170                 175     


Leu Ile Ala Ile Cys Tyr Pro Glu Met Val Met Lys Leu Ile Val Ile 
            180                 185                 190         


Asn Phe Pro His Pro Asn Val Phe Thr Glu Tyr Ile Leu Arg His Pro 
        195                 200                 205             


Ala Gln Leu Leu Lys Ser Ser Tyr Tyr Tyr Phe Phe Gln Ile Pro Trp 
    210                 215                 220                 


Phe Pro Glu Phe Met Phe Ser Ile Asn Asp Phe Lys Val Leu Lys His 
225                 230                 235                 240 


Leu Phe Thr Ser His Ser Thr Gly Ile Gly Arg Lys Gly Cys Gln Leu 
                245                 250                 255     


Thr Thr Glu Asp Leu Glu Ala Tyr Ile Tyr Val Phe Ser Gln Pro Gly 
            260                 265                 270         


Ala Leu Ser Gly Pro Ile Asn His Tyr Arg Asn Ile Phe Ser Cys Leu 
        275                 280                 285             


Pro Leu Lys His His Met Val Thr Thr Pro Thr Leu Leu Leu Trp Gly 
    290                 295                 300                 


Glu Asn Asp Ala Phe Met Glu Val Glu Met Ala Glu Val Thr Lys Ile 
305                 310                 315                 320 


Tyr Val Lys Asn Tyr Phe Arg Leu Thr Ile Leu Ser Glu Ala Ser His 
                325                 330                 335     


Trp Leu Gln Gln Asp Gln Pro Asp Ile Val Asn Lys Leu Ile Trp Thr 
            340                 345                 350         


Phe Leu Lys Glu Glu Thr Arg Lys Lys Asp 
        355                 360         


<210>  6360
<211>  409
<212>  PRT
<213>  Homo sapiens

<400>  6360

Met Thr Gln Lys Gly Ser Met Lys Pro Val Lys Lys Lys Lys Thr Glu 
1               5                   10                  15      


Glu Pro Glu Leu Glu Pro Leu Cys Cys Cys Glu Tyr Ile Asp Arg Asn 
            20                  25                  30          


Gly Glu Lys Asn His Val Ala Thr Cys Leu Cys Asp Cys Gln Asp Leu 
        35                  40                  45              


Asp Glu Gly Cys Asp Arg Trp Ile Thr Cys Lys Ser Leu Gln Pro Glu 
    50                  55                  60                  


Thr Cys Glu Arg Ile Met Asp Thr Ile Ser Asp Arg Leu Arg Ile Pro 
65                  70                  75                  80  


Trp Leu Arg Gly Ala Lys Lys Val Asn Ile Ser Ile Ile Pro Pro Leu 
                85                  90                  95      


Val Leu Leu Pro Val Phe Leu His Val Ala Ser Trp His Phe Leu Leu 
            100                 105                 110         


Gly Val Val Val Leu Thr Ser Leu Pro Val Leu Ala Leu Trp Tyr Tyr 
        115                 120                 125             


Tyr Leu Thr His Arg Arg Lys Glu Gln Thr Leu Phe Phe Leu Ser Leu 
    130                 135                 140                 


Gly Leu Phe Ser Leu Gly Tyr Met Tyr Tyr Val Phe Leu Gln Glu Val 
145                 150                 155                 160 


Val Pro Lys Gly Arg Val Gly Pro Val Gln Leu Ala Val Leu Thr Cys 
                165                 170                 175     


Gly Leu Phe Leu Ile Leu Leu Ala Leu His Arg Ala Lys Lys Asn Pro 
            180                 185                 190         


Gly Tyr Leu Ser Asn Pro Ala Ser Gly Asp Arg Ser Leu Ser Ser Ser 
        195                 200                 205             


Gln Leu Glu Cys Leu Ser Arg Lys Gly Gln Glu Lys Thr Lys Gly Phe 
    210                 215                 220                 


Pro Gly Ala Asp Met Ser Gly Ser Leu Asn Asn Arg Thr Thr Lys Asp 
225                 230                 235                 240 


Asp Pro Lys Gly Ser Ser Lys Met Pro Ala Gly Ser Pro Thr Lys Ala 
                245                 250                 255     


Lys Glu Asp Trp Cys Ala Lys Cys Gln Leu Val Arg Pro Ala Arg Ala 
            260                 265                 270         


Trp His Cys Arg Ile Cys Gly Ile Cys Val Arg Arg Met Asp His His 
        275                 280                 285             


Cys Val Trp Ile Asn Ser Cys Val Gly Glu Ser Asn His Gln Ala Phe 
    290                 295                 300                 


Ile Leu Ala Leu Leu Ile Phe Leu Leu Thr Ser Val Tyr Gly Ile Thr 
305                 310                 315                 320 


Leu Thr Leu Asp Thr Ile Cys Arg Asp Arg Ser Val Phe Thr Ala Leu 
                325                 330                 335     


Phe Tyr Cys Pro Gly Val Tyr Ala Asn Tyr Ser Ser Ala Leu Ser Phe 
            340                 345                 350         


Thr Cys Val Trp Tyr Ser Val Ile Ile Thr Ala Gly Met Ala Tyr Ile 
        355                 360                 365             


Phe Leu Ile Gln Leu Ile Asn Ile Ser Tyr Asn Val Thr Glu Arg Glu 
    370                 375                 380                 


Val Gln Gln Ala Leu Arg Gln Lys Thr Gly Arg Arg Leu Leu Cys Gly 
385                 390                 395                 400 


Leu Ile Val Asp Thr Gly Leu Leu Gly 
                405                 


<210>  6361
<211>  998
<212>  PRT
<213>  Homo sapiens

<400>  6361

Met Gly Ser Pro Arg Ala Ala Arg Pro Pro Leu Leu Leu Arg Pro Val 
1               5                   10                  15      


Lys Leu Leu Arg Arg Arg Phe Arg Leu Leu Leu Ala Leu Ala Val Val 
            20                  25                  30          


Ser Val Gly Leu Trp Thr Leu Tyr Leu Glu Leu Val Ala Ser Ala Gln 
        35                  40                  45              


Val Gly Gly Asn Pro Leu Asn Arg Arg Tyr Gly Ser Trp Arg Glu Leu 
    50                  55                  60                  


Ala Lys Ala Leu Ala Ser Arg Asn Ile Pro Ala Val Asp Pro His Leu 
65                  70                  75                  80  


Gln Phe Tyr His Pro Gln Arg Leu Ser Leu Glu Asp His Asp Ile Asp 
                85                  90                  95      


Gln Gly Val Ser Ser Asn Ser Ser Tyr Leu Lys Trp Asn Lys Pro Val 
            100                 105                 110         


Pro Trp Leu Ser Glu Phe Arg Gly Arg Ala Asn Leu His Val Phe Glu 
        115                 120                 125             


Asp Trp Cys Gly Ser Ser Ile Gln Gln Leu Arg Arg Asn Leu His Phe 
    130                 135                 140                 


Pro Leu Tyr Pro His Ile Arg Thr Thr Leu Arg Lys Leu Ala Val Ser 
145                 150                 155                 160 


Pro Lys Trp Thr Asn Tyr Gly Leu Arg Ile Phe Gly Tyr Leu His Pro 
                165                 170                 175     


Phe Thr Asp Gly Lys Ile Gln Phe Ala Ile Ala Ala Asp Asp Asn Ala 
            180                 185                 190         


Glu Phe Trp Leu Ser Leu Asp Asp Gln Val Ser Gly Leu Gln Leu Leu 
        195                 200                 205             


Ala Ser Val Gly Lys Thr Gly Lys Glu Trp Thr Ala Pro Gly Glu Phe 
    210                 215                 220                 


Gly Lys Phe Arg Ser Gln Ile Ser Lys Pro Val Ser Leu Ser Ala Ser 
225                 230                 235                 240 


His Arg Tyr Tyr Phe Glu Val Leu His Lys Gln Asn Glu Glu Gly Thr 
                245                 250                 255     


Asp His Val Glu Val Ala Trp Arg Arg Asn Asp Pro Gly Ala Lys Phe 
            260                 265                 270         


Thr Ile Ile Asp Ser Leu Ser Leu Ser Leu Phe Thr Asn Glu Thr Phe 
        275                 280                 285             


Leu Gln Met Asp Glu Val Gly His Ile Pro Gln Thr Ala Ala Ser His 
    290                 295                 300                 


Val Asp Ser Ser Asn Ala Leu Pro Arg Asp Glu Gln Pro Pro Ala Asp 
305                 310                 315                 320 


Met Leu Arg Pro Asp Pro Arg Asp Thr Leu Tyr Arg Val Pro Leu Ile 
                325                 330                 335     


Pro Lys Ser His Leu Arg His Val Leu Pro Asp Cys Pro Tyr Lys Pro 
            340                 345                 350         


Ser Tyr Leu Val Asp Gly Leu Pro Leu Gln Arg Tyr Gln Gly Leu Arg 
        355                 360                 365             


Phe Val His Leu Ser Phe Val Tyr Pro Asn Asp Tyr Thr Arg Leu Ser 
    370                 375                 380                 


His Met Glu Thr His Asn Lys Cys Phe Tyr Gln Glu Asn Ala Tyr Tyr 
385                 390                 395                 400 


Gln Asp Arg Phe Ser Phe Gln Glu Tyr Ile Lys Ile Asp Gln Pro Glu 
                405                 410                 415     


Lys Gln Gly Leu Glu Gln Pro Gly Phe Glu Glu Asn Leu Leu Glu Glu 
            420                 425                 430         


Ser Gln Tyr Gly Glu Val Ala Glu Glu Thr Pro Ala Ser Asn Asn Gln 
        435                 440                 445             


Asn Ala Arg Met Leu Glu Gly Arg Gln Thr Pro Ala Ser Thr Leu Glu 
    450                 455                 460                 


Gln Asp Ala Thr Asp Tyr Arg Leu Arg Ser Leu Arg Lys Leu Leu Ala 
465                 470                 475                 480 


Gln Pro Arg Glu Gly Leu Leu Ala Pro Phe Ser Lys Arg Asn Ser Thr 
                485                 490                 495     


Ala Ser Phe Pro Gly Arg Thr Ser His Ile Pro Val Gln Gln Pro Glu 
            500                 505                 510         


Lys Arg Lys Gln Lys Pro Ser Pro Glu Pro Ser Gln Asp Ser Pro His 
        515                 520                 525             


Ser Asp Lys Trp Pro Pro Gly His Pro Val Lys Asn Leu Pro Gln Met 
    530                 535                 540                 


Arg Gly Pro Arg Pro Arg Pro Ala Gly Asp Ser Pro Arg Lys Thr Gln 
545                 550                 555                 560 


Trp Leu Asn Gln Val Glu Ser Tyr Ile Ala Glu Gln Arg Arg Gly Asp 
                565                 570                 575     


Arg Met Arg Pro Gln Ala Pro Gly Arg Gly Trp His Gly Glu Glu Glu 
            580                 585                 590         


Val Val Ala Ala Ala Gly Gln Glu Gly Gln Val Glu Gly Glu Glu Glu 
        595                 600                 605             


Gly Glu Glu Glu Glu Glu Glu Glu Asp Met Ser Glu Val Phe Glu Tyr 
    610                 615                 620                 


Val Pro Val Phe Asp Pro Val Val Asn Trp Asp Gln Thr Phe Ser Ala 
625                 630                 635                 640 


Arg Asn Leu Asp Phe Gln Ala Leu Arg Thr Asp Trp Ile Asp Leu Ser 
                645                 650                 655     


Cys Asn Thr Ser Gly Asn Leu Leu Leu Pro Glu Gln Glu Ala Leu Glu 
            660                 665                 670         


Val Thr Arg Val Phe Leu Lys Lys Leu Asn Gln Arg Ser Arg Gly Arg 
        675                 680                 685             


Tyr Gln Leu Gln Arg Ile Val Asn Val Glu Lys Arg Gln Asp Gln Leu 
    690                 695                 700                 


Arg Gly Gly Arg Tyr Leu Leu Glu Leu Glu Leu Leu Glu Gln Gly Gln 
705                 710                 715                 720 


Arg Val Val Arg Leu Ser Glu Tyr Val Ser Ala Arg Gly Trp Gln Gly 
                725                 730                 735     


Ile Asp Pro Ala Gly Gly Glu Glu Val Glu Ala Arg Asn Leu Gln Gly 
            740                 745                 750         


Leu Val Trp Asp Pro His Asn Arg Arg Arg Gln Val Leu Asn Thr Arg 
        755                 760                 765             


Ala Gln Glu Pro Lys Leu Cys Trp Pro Gln Gly Phe Ser Trp Ser His 
    770                 775                 780                 


Arg Ala Val Val His Phe Val Val Pro Val Lys Asn Gln Ala Arg Trp 
785                 790                 795                 800 


Val Gln Gln Phe Ile Lys Asp Met Glu Asn Leu Phe Gln Val Thr Gly 
                805                 810                 815     


Asp Pro His Phe Asn Ile Val Ile Thr Asp Tyr Ser Ser Glu Asp Met 
            820                 825                 830         


Asp Val Glu Met Ala Leu Lys Arg Ser Lys Leu Arg Ser Tyr Gln Tyr 
        835                 840                 845             


Val Lys Leu Ser Gly Asn Phe Glu Arg Ser Ala Gly Leu Gln Ala Gly 
    850                 855                 860                 


Ile Asp Leu Val Lys Asp Pro His Ser Ile Ile Phe Leu Cys Asp Leu 
865                 870                 875                 880 


His Ile His Phe Pro Ala Gly Val Ile Asp Ala Ile Arg Lys His Cys 
                885                 890                 895     


Val Glu Gly Lys Met Ala Phe Ala Pro Met Val Met Arg Leu His Cys 
            900                 905                 910         


Gly Ala Thr Pro Gln Trp Pro Glu Gly Tyr Trp Glu Val Asn Gly Phe 
        915                 920                 925             


Gly Leu Leu Gly Ile Tyr Lys Ser Asp Leu Asp Arg Ile Gly Gly Met 
    930                 935                 940                 


Asn Thr Lys Glu Phe Arg Asp Arg Trp Gly Gly Glu Asp Trp Glu Leu 
945                 950                 955                 960 


Leu Asp Arg Ile Leu Gln Ala Gly Leu Asp Val Glu Arg Leu Ser Leu 
                965                 970                 975     


Arg Asn Phe Phe His His Phe His Ser Lys Arg Gly Met Trp Ser Arg 
            980                 985                 990         


Arg Gln Met Lys Thr Leu 
        995             


<210>  6362
<211>  540
<212>  PRT
<213>  Homo sapiens

<400>  6362

Met Met Gly Ser Pro Val Ser His Leu Leu Ala Gly Phe Cys Val Trp 
1               5                   10                  15      


Val Val Leu Gly Trp Val Gly Gly Ser Val Pro Asn Leu Gly Pro Ala 
            20                  25                  30          


Glu Gln Glu Gln Asn His Tyr Leu Ala Gln Leu Phe Gly Leu Tyr Gly 
        35                  40                  45              


Glu Asn Gly Thr Leu Thr Ala Gly Gly Leu Ala Arg Leu Leu His Ser 
    50                  55                  60                  


Leu Gly Leu Gly Arg Val Gln Gly Leu Arg Leu Gly Gln His Gly Pro 
65                  70                  75                  80  


Leu Thr Gly Arg Ala Ala Ser Pro Ala Ala Asp Asn Ser Thr His Arg 
                85                  90                  95      


Pro Gln Asn Pro Glu Leu Ser Val Asp Val Trp Ala Gly Met Pro Leu 
            100                 105                 110         


Gly Pro Ser Gly Trp Gly Asp Leu Glu Glu Ser Lys Ala Pro His Leu 
        115                 120                 125             


Pro Arg Gly Pro Ala Pro Ser Gly Leu Asp Leu Leu His Arg Leu Leu 
    130                 135                 140                 


Leu Leu Asp His Ser Leu Ala Asp His Leu Asn Glu Asp Cys Leu Asn 
145                 150                 155                 160 


Gly Ser Gln Leu Leu Val Asn Phe Gly Leu Ser Pro Ala Ala Pro Leu 
                165                 170                 175     


Thr Pro Arg Gln Phe Ala Leu Leu Cys Pro Ala Leu Leu Tyr Gln Ile 
            180                 185                 190         


Asp Ser Arg Val Cys Ile Gly Ala Pro Ala Pro Ala Pro Pro Gly Asp 
        195                 200                 205             


Leu Leu Ser Ala Leu Leu Gln Ser Ala Leu Ala Val Leu Leu Leu Ser 
    210                 215                 220                 


Leu Pro Ser Pro Leu Ser Leu Leu Leu Leu Arg Leu Leu Gly Pro Arg 
225                 230                 235                 240 


Leu Leu Arg Pro Leu Leu Gly Phe Leu Gly Ala Leu Ala Val Gly Thr 
                245                 250                 255     


Leu Cys Gly Asp Ala Leu Leu His Leu Leu Pro His Ala Gln Glu Gly 
            260                 265                 270         


Arg His Ala Gly Pro Gly Gly Leu Pro Glu Lys Asp Leu Gly Pro Gly 
        275                 280                 285             


Leu Ser Val Leu Gly Gly Leu Phe Leu Leu Phe Val Leu Glu Asn Met 
    290                 295                 300                 


Leu Gly Leu Leu Arg His Arg Gly Leu Arg Pro Arg Cys Cys Arg Arg 
305                 310                 315                 320 


Lys Arg Arg Asn Leu Glu Thr Arg Asn Leu Asp Pro Glu Asn Gly Ser 
                325                 330                 335     


Gly Met Ala Leu Gln Pro Leu Gln Ala Ala Pro Glu Pro Gly Ala Gln 
            340                 345                 350         


Gly Gln Arg Glu Lys Asn Ser Gln His Pro Pro Ala Leu Ala Pro Pro 
        355                 360                 365             


Gly His Gln Gly His Ser His Gly His Gln Gly Gly Thr Asp Ile Thr 
    370                 375                 380                 


Trp Met Val Leu Leu Gly Asp Gly Leu His Asn Leu Thr Asp Gly Leu 
385                 390                 395                 400 


Ala Ile Gly Ala Ala Phe Ser Asp Gly Phe Ser Ser Gly Leu Ser Thr 
                405                 410                 415     


Thr Leu Ala Val Phe Cys His Glu Leu Pro His Glu Leu Gly Asp Phe 
            420                 425                 430         


Ala Met Leu Leu Gln Ser Gly Leu Ser Phe Arg Arg Leu Leu Leu Leu 
        435                 440                 445             


Ser Leu Val Ser Gly Ala Leu Gly Leu Gly Gly Ala Val Leu Gly Val 
    450                 455                 460                 


Gly Leu Ser Leu Gly Pro Val Pro Leu Thr Pro Trp Val Phe Gly Val 
465                 470                 475                 480 


Thr Ala Gly Val Phe Leu Tyr Val Ala Leu Val Asp Met Leu Pro Ala 
                485                 490                 495     


Leu Leu Arg Pro Pro Glu Pro Leu Pro Thr Pro His Val Leu Leu Gln 
            500                 505                 510         


Gly Leu Gly Leu Leu Leu Gly Gly Gly Leu Met Leu Ala Ile Thr Leu 
        515                 520                 525             


Leu Glu Glu Arg Leu Leu Pro Val Thr Thr Glu Gly 
    530                 535                 540 


<210>  6363
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  6363

Met Arg Arg Tyr Leu Arg Val Val Val Leu Cys Val Ala Cys Gly Phe 
1               5                   10                  15      


Cys Ser Leu Leu Tyr Ala Phe Ser Gln Leu Ala Val Ser Leu Glu Glu 
            20                  25                  30          


Gly Thr Gly Gly Gly Gly Gly Lys Pro Gln Ala Ala Val Ala Ser Trp 
        35                  40                  45              


Leu Ala Gly Gly Gly Arg Gly Ala Val Arg Gly Ala Gly Val Ala Gly 
    50                  55                  60                  


Pro Ala Ala His Pro Gly Val Ser Asp Arg Cys Lys Asp Phe Ser Leu 
65                  70                  75                  80  


Cys Tyr Trp Asn Pro Tyr Trp Met Leu Pro Ser Asp Val Cys Gly Met 
                85                  90                  95      


Asn Cys Phe Trp Glu Ala Ala Phe Arg Tyr Ser Leu Lys Ile Gln Pro 
            100                 105                 110         


Val Glu Lys Met His Leu Ala Val Val Ala Cys Gly Glu Arg Leu Glu 
        115                 120                 125             


Glu Thr Met Thr Met Leu Lys Ser Ala Ile Ile Phe Ser Ile Lys Pro 
    130                 135                 140                 


Leu Gln Phe His Ile Phe Ala Glu Asp Gln Leu His His Ser Phe Lys 
145                 150                 155                 160 


Gly Arg Leu Asp Asn Trp Ser Phe Leu Gln Thr Phe Asn Tyr Thr Leu 
                165                 170                 175     


Tyr Pro Ile Thr Phe Pro Ser Glu Asn Ala Ala Glu Trp Lys Lys Leu 
            180                 185                 190         


Phe Lys Pro Cys Ala Ser Gln Arg Leu Phe Leu Pro Leu Ile Leu Lys 
        195                 200                 205             


Glu Val Asp Ser Leu Leu Tyr Val Asp Thr Asp Ile Leu Phe Leu Arg 
    210                 215                 220                 


Pro Val Asp Asp Ile Trp Ser Leu Leu Lys Lys Phe Asn Ser Thr Gln 
225                 230                 235                 240 


Ile Ala Ala Met Ala Pro Glu His Glu Glu Pro Arg Ile Gly Trp Tyr 
                245                 250                 255     


Asn Arg Phe Ala Arg His Pro Tyr Tyr Gly Lys Thr Gly Val Asn Ser 
            260                 265                 270         


Gly Val Met Leu Met Asn Met Thr Arg Met Arg Arg Lys Tyr Phe Lys 
        275                 280                 285             


Asn Asp Met Thr Thr Val Arg Leu Gln Trp Gly Asp Ile Leu Met Pro 
    290                 295                 300                 


Leu Leu Lys Lys Tyr Lys Leu Asn Ile Thr Trp Gly Asp Gln Asp Leu 
305                 310                 315                 320 


Leu Asn Ile Val Phe Phe His Asn Pro Glu Ser Leu Phe Val Phe Pro 
                325                 330                 335     


Cys Gln Trp Asn Tyr Arg Pro Asp His Cys Ile Tyr Gly Ser Asn Cys 
            340                 345                 350         


Gln Glu Ala Glu Glu Gly Gly Ile Phe Ile Leu His Gly Asn Arg Gly 
        355                 360                 365             


Val Tyr His Asp Asp Lys Gln Pro Ala Phe Arg Ala Val Tyr Glu Ala 
    370                 375                 380                 


Leu Arg Asn Cys Ser Phe Glu Asp Asp Asn Ile Arg Ser Leu Leu Lys 
385                 390                 395                 400 


Pro Leu Glu Leu Glu Leu Gln Lys Thr Val His Thr Tyr Cys Gly Lys 
                405                 410                 415     


Ile Tyr Lys Ile Phe Ile Lys Gln Leu Ala Lys Ser Val Arg Asp Arg 
            420                 425                 430         


Tyr Ala Arg Ser Pro Lys Glu Lys 
        435                 440 


<210>  6364
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  6364

Met Ser Ser Gln Glu Leu Val Thr Leu Asn Val Gly Gly Lys Ile Phe 
1               5                   10                  15      


Thr Thr Arg Phe Ser Thr Ile Lys Gln Phe Pro Ala Ser Arg Leu Ala 
            20                  25                  30          


Arg Met Leu Asp Gly Arg Asp Gln Glu Phe Lys Met Val Gly Gly Gln 
        35                  40                  45              


Ile Phe Val Asp Arg Asp Gly Asp Leu Phe Ser Phe Ile Leu Asp Phe 
    50                  55                  60                  


Leu Arg Thr His Gln Leu Leu Leu Pro Thr Glu Phe Ser Asp Tyr Leu 
65                  70                  75                  80  


Arg Leu Gln Arg Glu Ala Leu Phe Tyr Glu Leu Arg Ser Leu Val Asp 
                85                  90                  95      


Leu Leu Asn Pro Tyr Leu Leu Gln Pro Arg Pro Ala Leu Val Glu Val 
            100                 105                 110         


His Phe Leu Ser Arg Asn Thr Gln Ala Phe Phe Arg Val Phe Gly Ser 
        115                 120                 125             


Cys Ser Lys Thr Ile Glu Met Leu Thr Gly Arg Ile Thr Val Phe Thr 
    130                 135                 140                 


Glu Gln Pro Ser Ala Pro Thr Trp Asn Gly Asn Phe Phe Pro Pro Gln 
145                 150                 155                 160 


Met Thr Leu Leu Pro Leu Pro Pro Gln Arg Pro Ser Tyr His Asp Leu 
                165                 170                 175     


Val Phe Gln Cys Gly Ser Asp Ser Thr Thr Asp Asn Gln Thr Gly Val 
            180                 185                 190         


Arg Tyr Val Ser Ile Lys Pro Asp Asn Arg Lys Leu Ala Asn Gly Thr 
        195                 200                 205             


Asn Val Leu Gly Leu Leu Ile Asp Thr Leu Leu Lys Glu Gly Phe His 
    210                 215                 220                 


Leu Val Ser Thr Arg Thr Val Ser Ser Glu Asp Lys Thr Glu Cys Tyr 
225                 230                 235                 240 


Ser Phe Glu Arg Ile Lys Ser Pro Glu Val Leu Ile Thr Asn Glu Thr 
                245                 250                 255     


Pro Lys Pro Glu Thr Ile Ile Ile Pro Glu Gln Ser Gln Ile Lys Lys 
            260                 265                 270         


<210>  6365
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  6365

Met Asp Thr Ile Leu Val Phe Ser Leu Ile Ile Ala Ser Tyr Asp Ala 
1               5                   10                  15      


Asn Lys Lys Asp Leu Arg Asp Ser Ser Cys Arg Leu Glu Gln Leu Pro 
            20                  25                  30          


Gly Ile Phe Pro Lys Asp Val Arg Ser Ile Arg Glu Leu Gln Met Gln 
        35                  40                  45              


Glu Thr His Thr Glu Thr Lys Arg Thr Thr Phe Ile Gln Asn Arg Thr 
    50                  55                  60                  


Ile Ala Thr Leu Gln Cys Leu Gly Ser Asp Ser Lys Val Lys Val Asn 
65                  70                  75                  80  


Leu Val Tyr Leu Glu Arg Arg Pro Lys Val Lys His Ile Leu Lys Asn 
                85                  90                  95      


Leu Arg Ile Ile Ala Ala Pro Arg Arg Asn Ser Ser Ala Ser Ser Ser 
            100                 105                 110         


Cys His Leu Ile Pro Thr Ser Lys Phe Gln Thr Gly Ser Leu Leu Lys 
        115                 120                 125             


Gly Lys Ala Phe Leu Pro Gly Ile Ser Gln Cys Lys Val Leu Gly Ala 
    130                 135                 140                 


Ser Ser Glu Thr Phe Pro Thr Thr Ala Pro Ser Ile Thr Pro Gly Asn 
145                 150                 155                 160 


Lys Glu Gly Glu Lys Thr Thr Ser Thr Asp Thr Asp Glu Asn Leu Glu 
                165                 170                 175     


Lys Arg Gln Lys Trp Ser Ile Val Val Lys Ile Leu Ile Ala Val Thr 
            180                 185                 190         


Leu Leu Leu Ser Gly Val Ala Ile Ile Val Phe Val Ile Phe Glu Val 
        195                 200                 205             


Pro Cys Pro Tyr Gln Cys Leu Gly Ala Arg Lys Leu Cys Gln Cys Gln 
    210                 215                 220                 


Trp Leu Trp Arg Trp Gln Lys Lys Gly Gly Gln Pro Pro Gly Thr Ala 
225                 230                 235                 240 


Glu Ser Lys Pro Asp Ser Gln Pro Gln Lys Val Gly Gln Asp Ala Ala 
                245                 250                 255     


Asn Ser Ser Asn Pro Lys Lys Ala Ala Glu Ile Thr Val Ile His Gln 
            260                 265                 270         


Thr Tyr Phe 
        275 


<210>  6366
<211>  606
<212>  PRT
<213>  Homo sapiens

<400>  6366

Met Pro Ser Ser Val Thr Ala Leu Gly Gln Ala Arg Ser Ser Gly Pro 
1               5                   10                  15      


Gly Met Ala Pro Ser Ala Cys Cys Cys Ser Pro Ala Ala Leu Gln Arg 
            20                  25                  30          


Arg Leu Pro Ile Leu Ala Trp Leu Pro Ser Tyr Ser Leu Gln Trp Leu 
        35                  40                  45              


Lys Met Asp Phe Val Ala Gly Leu Ser Val Gly Leu Thr Ala Ile Pro 
    50                  55                  60                  


Gln Ala Leu Ala Tyr Ala Glu Val Ala Gly Leu Pro Pro Gln Tyr Gly 
65                  70                  75                  80  


Leu Tyr Ser Ala Phe Met Gly Cys Phe Val Tyr Phe Phe Leu Gly Thr 
                85                  90                  95      


Ser Arg Asp Val Thr Leu Gly Pro Thr Ala Ile Met Ser Leu Leu Val 
            100                 105                 110         


Ser Phe Tyr Thr Phe His Glu Pro Ala Tyr Ala Val Leu Leu Ala Phe 
        115                 120                 125             


Leu Ser Gly Cys Ile Gln Leu Ala Met Gly Val Leu Arg Leu Gly Phe 
    130                 135                 140                 


Leu Leu Asp Phe Ile Ser Tyr Pro Val Ile Lys Gly Phe Thr Ser Ala 
145                 150                 155                 160 


Ala Ala Val Thr Ile Gly Phe Gly Gln Ile Lys Asn Leu Leu Gly Leu 
                165                 170                 175     


Gln Asn Ile Pro Arg Pro Phe Phe Leu Gln Val Tyr His Thr Phe Leu 
            180                 185                 190         


Arg Ile Ala Glu Thr Arg Val Gly Asp Ala Val Leu Gly Leu Val Cys 
        195                 200                 205             


Met Leu Leu Leu Leu Val Leu Lys Leu Met Arg Asp His Val Pro Pro 
    210                 215                 220                 


Val His Pro Glu Met Pro Pro Gly Val Arg Leu Ser Arg Gly Leu Val 
225                 230                 235                 240 


Trp Ala Ala Thr Thr Ala Arg Asn Ala Leu Val Val Ser Phe Ala Ala 
                245                 250                 255     


Leu Val Ala Tyr Ser Phe Glu Val Thr Gly Tyr Gln Pro Phe Ile Leu 
            260                 265                 270         


Thr Gly Glu Thr Ala Glu Gly Leu Pro Pro Val Arg Ile Pro Pro Phe 
        275                 280                 285             


Ser Val Thr Thr Ala Asn Gly Thr Ile Ser Phe Thr Glu Met Val Gln 
    290                 295                 300                 


Asp Met Gly Ala Gly Leu Ala Val Val Pro Leu Met Gly Leu Leu Glu 
305                 310                 315                 320 


Ser Ile Ala Val Ala Lys Ala Phe Ala Ser Gln Asn Asn Tyr Arg Ile 
                325                 330                 335     


Asp Ala Asn Gln Glu Leu Leu Ala Ile Gly Leu Thr Asn Met Leu Gly 
            340                 345                 350         


Ser Leu Val Ser Ser Tyr Pro Val Thr Gly Ser Phe Gly Arg Thr Ala 
        355                 360                 365             


Val Asn Ala Gln Ser Gly Val Cys Thr Pro Ala Gly Gly Leu Val Thr 
    370                 375                 380                 


Gly Val Leu Val Leu Leu Ser Leu Asp Tyr Leu Thr Ser Leu Phe Tyr 
385                 390                 395                 400 


Tyr Ile Pro Lys Ser Ala Leu Ala Ala Val Ile Ile Met Ala Val Ala 
                405                 410                 415     


Pro Leu Phe Asp Thr Lys Ile Phe Arg Thr Leu Trp Arg Val Lys Arg 
            420                 425                 430         


Leu Asp Leu Leu Pro Leu Cys Val Thr Phe Leu Leu Cys Phe Trp Glu 
        435                 440                 445             


Val Gln Tyr Gly Ile Leu Ala Gly Ala Leu Val Ser Leu Leu Met Leu 
    450                 455                 460                 


Leu His Ser Ala Ala Arg Pro Glu Thr Lys Val Ser Glu Gly Pro Val 
465                 470                 475                 480 


Leu Val Leu Gln Pro Ala Ser Gly Leu Ser Phe Pro Ala Met Glu Ala 
                485                 490                 495     


Leu Arg Glu Glu Ile Leu Ser Arg Ala Leu Glu Val Ser Pro Pro Arg 
            500                 505                 510         


Cys Leu Val Leu Glu Cys Thr His Val Cys Ser Ile Asp Tyr Thr Val 
        515                 520                 525             


Val Leu Gly Leu Gly Glu Leu Leu Gln Asp Phe Gln Lys Gln Gly Val 
    530                 535                 540                 


Ala Leu Ala Phe Val Gly Leu Gln Val Pro Val Leu Arg Val Leu Leu 
545                 550                 555                 560 


Ser Ala Asp Leu Lys Gly Phe Gln Tyr Phe Ser Thr Leu Glu Glu Ala 
                565                 570                 575     


Glu Lys His Leu Arg Gln Glu Pro Gly Thr Gln Pro Tyr Asn Ile Arg 
            580                 585                 590         


Glu Asp Ser Ile Leu Asp Gln Lys Val Ala Leu Leu Lys Ala 
        595                 600                 605     


<210>  6367
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  6367

Met Glu Pro Leu Arg Ala Pro Ala Leu Arg Arg Leu Leu Pro Pro Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ser Leu Pro Pro Arg Ala Arg Ala Lys Tyr Val 
            20                  25                  30          


Arg Gly Asn Leu Ser Ser Lys Glu Asp Trp Val Phe Leu Thr Arg Phe 
        35                  40                  45              


Cys Phe Leu Ser Asp Tyr Gly Arg Leu Asp Phe Arg Phe Arg Tyr Pro 
    50                  55                  60                  


Glu Ala Lys Cys Cys Gln Asn Ile Leu Leu Tyr Phe Asp Asp Pro Ser 
65                  70                  75                  80  


Gln Trp Pro Ala Val Tyr Lys Ala Gly Asp Lys Asp Cys Leu Ala Lys 
                85                  90                  95      


Glu Ser Val Ile Arg Pro Glu Asn Asn Gln Val Ile Asn Leu Thr Thr 
            100                 105                 110         


Gln Tyr Ala Trp Ser Gly Cys Gln Val Val Ser Glu Glu Gly Thr Arg 
        115                 120                 125             


Tyr Leu Ser Cys Ser Ser Gly Arg Ser Phe Arg Ser Gly Asp Gly Leu 
    130                 135                 140                 


Gln Leu Glu Tyr Glu Met Val Leu Thr Asn Gly Lys Ser Phe Trp Thr 
145                 150                 155                 160 


Arg His Phe Ser Ala Asp Glu Phe Gly Ile Leu Glu Thr Asp Val Thr 
                165                 170                 175     


Phe Leu Leu Ile Phe Ile Leu Ile Phe Phe Leu Ser Cys Tyr Phe Gly 
            180                 185                 190         


Tyr Leu Leu Lys Gly Arg Gln Leu Leu His Thr Thr Tyr Lys Met Phe 
        195                 200                 205             


Met Ala Ala Ala Gly Val Glu Val Leu Ser Leu Leu Phe Phe Cys Ile 
    210                 215                 220                 


Tyr Trp Gly Gln Tyr Ala Thr Asp Gly Ile Gly Asn Glu Ser Val Lys 
225                 230                 235                 240 


Ile Leu Ala Lys Leu Leu Phe Ser Ser Ser Phe Leu Ile Phe Leu Leu 
                245                 250                 255     


Met Leu Ile Leu Leu Gly Lys Gly Phe Thr Val Thr Arg Gly Arg Ile 
            260                 265                 270         


Ser His Ala Gly Ser Val Lys Leu Ser Val Tyr Met Thr Leu Tyr Thr 
        275                 280                 285             


Leu Thr His Val Val Leu Leu Ile Tyr Glu Ala Glu Phe Phe Asp Pro 
    290                 295                 300                 


Gly Gln Val Leu Tyr Thr Tyr Glu Ser Pro Ala Gly Tyr Gly Leu Ile 
305                 310                 315                 320 


Gly Leu Gln Val Ala Ala Tyr Val Trp Phe Cys Tyr Ala Val Leu Val 
                325                 330                 335     


Ser Leu Arg His Phe Pro Glu Lys Gln Pro Phe Tyr Val Pro Phe Phe 
            340                 345                 350         


Ala Ala Tyr Thr Leu Trp Phe Phe Ala Val Pro Val Met Ala Leu Ile 
        355                 360                 365             


Ala Asn Phe Gly Ile Pro Lys Trp Ala Arg Glu Lys Ile Val Asn Gly 
    370                 375                 380                 


Ile Gln Leu Gly Ile His Leu Tyr Ala His Gly Val Phe Leu Ile Met 
385                 390                 395                 400 


Thr Arg Pro Ser Ala Ala Asn Lys Asn Phe Pro Tyr His Val Arg Thr 
                405                 410                 415     


Ser Gln Ile Ala Ser Ala Gly Val Pro Gly Pro Gly Gly Ser Gln Ser 
            420                 425                 430         


Ala Asp Lys Ala Phe Pro Gln His Val Tyr Gly Asn Val Thr Phe Ile 
        435                 440                 445             


Ser Asp Ser Val Pro Asn Phe Thr Glu Leu Phe Ser Ile Pro Pro Pro 
    450                 455                 460                 


Ala Thr Ser Pro Leu Pro Arg Ala Ala Pro Asp Ser Gly Leu Pro Leu 
465                 470                 475                 480 


Phe Arg Asp Leu Arg Pro Pro Gly Pro Leu Arg Asp Leu 
                485                 490             


<210>  6368
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  6368

Met Leu Pro Leu Leu Gln Leu Val Pro Ala Lys Leu Leu Asn Ser Ser 
1               5                   10                  15      


Cys Ser Leu Glu Lys Thr Leu Gln Cys Ser Cys Ser Phe His Gly Ile 
            20                  25                  30          


Pro Thr Pro Ser Val Gln Trp Trp Met Gly Gly Val Pro Val Gly Val 
        35                  40                  45              


Asp Gly Met Asp Gly Ser Leu Gln Val Thr Ser Thr Met Leu Gly Pro 
    50                  55                  60                  


Trp Ala Asn Ser Thr Ile Ser Leu Thr Glu Glu Pro Glu Met Gly Met 
65                  70                  75                  80  


Arg Leu Leu Cys Glu Gly Lys Asn Gln Asn Gly Thr His Ala Leu Ser 
                85                  90                  95      


Ile Leu Leu Met Ser Arg Lys Ser Ser Leu Ala Ala Gln Ala Phe Val 
            100                 105                 110         


Lys Gly Leu Ile Gln Gly Ala Ile Tyr Ala Gly Ile Val Ile Ala Leu 
        115                 120                 125             


Leu Phe Leu Cys Leu Leu Pro Leu Ile Val Lys His Ile Arg Lys Lys 
    130                 135                 140                 


Gln Ala Lys Lys Ala Ala Ala Ile Arg Ala Lys Lys Ser Ser Lys Val 
145                 150                 155                 160 


Arg Ala Ser Gln Glu Leu Glu Met Ser Leu Lys Pro Glu Glu Pro Gly 
                165                 170                 175     


Lys Pro Val Val Ala Thr Phe Ser Glu Ser Arg Ile Leu Glu Lys Gln 
            180                 185                 190         


Asp Lys Arg Ala Ser 
        195         


<210>  6369
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  6369

Met Glu Thr Cys Ala Gly Pro His Pro Leu Arg Leu Phe Leu Cys Arg 
1               5                   10                  15      


Met Gln Leu Cys Leu Ala Leu Leu Leu Gly Pro Trp Arg Pro Gly Thr 
            20                  25                  30          


Ala Glu Glu Val Ile Leu Leu Asp Ser Lys Ala Ser Gln Ala Glu Leu 
        35                  40                  45              


Gly Trp Thr Ala Leu Pro Ser Asn Gly Trp Glu Glu Ile Ser Gly Val 
    50                  55                  60                  


Asp Glu His Asp Arg Pro Ile Arg Thr Tyr Gln Val Cys Asn Val Leu 
65                  70                  75                  80  


Glu Pro Asn Gln Asp Asn Trp Leu Gln Thr Gly Trp Ile Ser Arg Gly 
                85                  90                  95      


Arg Gly Gln Arg Ile Phe Val Glu Leu Gln Phe Thr Leu Arg Asp Cys 
            100                 105                 110         


Ser Ser Ile Pro Gly Ala Ala Gly Thr Cys Lys Glu Thr Phe Asn Val 
        115                 120                 125             


Tyr Tyr Leu Glu Thr Glu Ala Asp Leu Gly Arg Gly Arg Pro Arg Leu 
    130                 135                 140                 


Gly Gly Ser Arg Pro Arg Lys Ile Asp Thr Ile Ala Ala Asp Glu Ser 
145                 150                 155                 160 


Phe Thr Gln Gly Asp Leu Gly Glu Arg Lys Met Lys Leu Asn Thr Glu 
                165                 170                 175     


Val Arg Glu Ile Gly Pro Leu Ser Arg Arg Gly Phe His Leu Ala Phe 
            180                 185                 190         


Gln Asp Val Gly Ala Cys Val Ala Leu Val Ser Val Arg Val Tyr Tyr 
        195                 200                 205             


Lys Gln Cys Arg Ala Thr Val Arg Gly Leu Ala Thr Phe Pro Ala Thr 
    210                 215                 220                 


Ala Ala Glu Ser Ala Phe Ser Thr Leu Val Glu Val Ala Gly Thr Cys 
225                 230                 235                 240 


Val Ala His Ser Glu Gly Glu Pro Gly Ser Pro Pro Arg Met His Cys 
                245                 250                 255     


Gly Ala Asp Gly Glu Trp Leu Val Pro Val Gly Arg Cys Ser Cys Ser 
            260                 265                 270         


Ala Gly Phe Gln Glu Arg Gly Asp Phe Cys Glu Gly Ile Gln Leu Ala 
        275                 280                 285             


Gly Gly Arg Gly Val Gly Val 
    290                 295 


<210>  6370
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  6370

Met Ala Trp Arg Arg Arg Glu Ala Ser Val Gly Ala Arg Gly Val Leu 
1               5                   10                  15      


Ala Leu Ala Leu Leu Ala Leu Ala Leu Cys Val Pro Gly Ala Arg Gly 
            20                  25                  30          


Arg Ala Leu Glu Trp Phe Ser Ala Val Val Asn Ile Glu Tyr Val Asp 
        35                  40                  45              


Pro Gln Thr Asn Leu Thr Val Trp Ser Val Ser Glu Ser Gly Arg Phe 
    50                  55                  60                  


Gly Asp Ser Ser Pro Lys Glu Gly Ala His Gly Leu Val Gly Val Pro 
65                  70                  75                  80  


Trp Ala Pro Gly Gly Asp Leu Glu Gly Cys Ala Pro Asp Thr Arg Phe 
                85                  90                  95      


Phe Val Pro Glu Pro Gly Gly Arg Gly Ala Ala Pro Trp Val Ala Leu 
            100                 105                 110         


Val Ala Arg Gly Gly Cys Thr Phe Lys Asp Lys Val Leu Val Ala Ala 
        115                 120                 125             


Arg Arg Asn Ala Ser Ala Val Val Leu Tyr Asn Glu Glu Arg Tyr Gly 
    130                 135                 140                 


Asn Ile Thr Leu Pro Met Ser His Ala Gly Thr Gly Asn Ile Val Val 
145                 150                 155                 160 


Ile Met Ile Ser Tyr Pro Lys Gly Arg Glu Ile Leu Glu Leu Val Gln 
                165                 170                 175     


Lys Gly Ile Pro Val Thr Met Thr Ile Gly Val Gly Thr Arg His Val 
            180                 185                 190         


Gln Glu Phe Ile Ser Gly Gln Ser Val Val Phe Val Ala Ile Ala Phe 
        195                 200                 205             


Ile Thr Met Met Ile Ile Ser Leu Ala Trp Leu Ile Phe Tyr Tyr Ile 
    210                 215                 220                 


Gln Arg Phe Leu Tyr Thr Gly Ser Gln Ile Gly Ser Gln Ser His Arg 
225                 230                 235                 240 


Lys Glu Thr Lys Lys Val Ile Gly Gln Leu Leu Leu His Thr Val Lys 
                245                 250                 255     


His Gly Glu Lys Gly Ile Asp Val Asp Ala Glu Asn Cys Ala Val Cys 
            260                 265                 270         


Ile Glu Asn Phe Lys Val Lys Asp Ile Ile Arg Ile Leu Pro Cys Lys 
        275                 280                 285             


His Ile Phe His Arg Ile Cys Ile Asp Pro Trp Leu Leu Asp His Arg 
    290                 295                 300                 


Thr Cys Pro Met Cys Lys Leu Asp Val Ile Lys Ala Leu Gly Tyr Trp 
305                 310                 315                 320 


Gly Glu Pro Gly Asp Val Gln Glu Met Pro Ala Pro Glu Ser Pro Pro 
                325                 330                 335     


Gly Arg Asp Pro Ala Ala Asn Leu Ser Leu Ala Leu Pro Asp Asp Asp 
            340                 345                 350         


Gly Ser Asp Asp Ser Ser Pro Pro Ser Ala Ser Pro Ala Glu Ser Glu 
        355                 360                 365             


Pro Gln Cys Asp Pro Ser Phe Lys Gly Asp Ala Gly Glu Asn Thr Ala 
    370                 375                 380                 


Leu Leu Glu Ala Gly Arg Ser Asp Ser Arg His Gly Gly Pro Ile Ser 
385                 390                 395                 400 


<210>  6371
<211>  1530
<212>  PRT
<213>  Homo sapiens

<400>  6371

Met Ser Ser Gln Gly Ser Pro Ser Val Ala Leu Ser Thr Thr Thr Val 
1               5                   10                  15      


Ser Ser Val Ala Val Gln Ala Gly Asp Ser Lys Ile Val Ile Ala Val 
            20                  25                  30          


Ile Lys Cys Gly Lys Trp Val Gln Leu Gln Leu Ala Glu Ser Gln Pro 
        35                  40                  45              


Asn Leu Leu Glu Ile Gly Ser Ser Gln Asp Glu Thr Lys Lys Leu Leu 
    50                  55                  60                  


His Asp His Glu Leu Leu Leu Ala Lys Leu Lys Ala Leu Glu Asp Arg 
65                  70                  75                  80  


Val Trp Glu Leu Leu Gln Glu Ala Asp Lys Thr Ala Glu Glu Asn Lys 
                85                  90                  95      


Asp Gln Ser Gln Val Tyr Asp Ala Met Ala Glu Thr Leu Gly Glu Ala 
            100                 105                 110         


Trp Ala Ala Leu Val Ser Met Leu Glu Arg Arg Thr Glu Leu Leu Arg 
        115                 120                 125             


Leu Thr Ser Glu Phe Phe Glu Asn Ala Leu Glu Phe Ala Ile Lys Ile 
    130                 135                 140                 


Asp Gln Ala Glu Asp Phe Leu Gln Asn Thr His Glu Phe Glu Ser Ala 
145                 150                 155                 160 


Glu Ser Leu Lys Ser Leu Leu Gln Leu His Glu His His Thr Lys Glu 
                165                 170                 175     


Leu Leu Glu Arg Ser Leu Ala Leu Leu Asn Lys Ser Gln Gln Leu Thr 
            180                 185                 190         


Asp Phe Ile Glu Lys Phe Lys Cys Glu Gly Pro Asn Val Asn Pro Glu 
        195                 200                 205             


Leu Thr Gln Gly Ala His Ser Ser Cys Leu Lys Val Asp Arg Leu Leu 
    210                 215                 220                 


Glu Leu Leu Gln Asp Arg Arg Arg Gln Leu Asp Lys Tyr Leu Lys Gln 
225                 230                 235                 240 


Gln Trp Gln Glu Leu Ser Gln Val Leu Gln Ile Cys Gln Trp Asp Gln 
                245                 250                 255     


Gln Glu Asn Gln Val Thr Cys Trp Phe Gln Lys Thr Ile Arg Asn Leu 
            260                 265                 270         


Gln Glu Gln Ser Leu Gly Ser Ser Leu Ser Asp Asn Glu Asp Arg Ile 
        275                 280                 285             


His Lys Gln Glu Glu Leu Ile Ile Lys Ala Lys Glu Trp Asn Ser Ala 
    290                 295                 300                 


Val Glu Lys Leu Lys Ser Glu Ala Leu Arg Ile Leu Leu Ser Lys Asp 
305                 310                 315                 320 


Tyr Val Glu Lys Glu His Leu Gln Leu Ser His Gln Lys Leu Ser Gln 
                325                 330                 335     


Leu Gln Glu Glu Phe Gly Gln Leu Met Val Glu Arg Asn Thr Trp Leu 
            340                 345                 350         


Lys Lys Ala Asn Glu Phe Phe Asn Ser Ala Asn Lys Ala Phe Asp Val 
        355                 360                 365             


Leu Gly Arg Val Glu Ala Tyr Leu Lys Leu Leu Lys Ser Glu Gly Leu 
    370                 375                 380                 


Ser Leu Ala Val Leu Ala Val Arg His Glu Glu Leu His Arg Lys Ile 
385                 390                 395                 400 


Lys Asp Cys Thr Thr Asp Ala Leu Gln Lys Gly Gln Thr Leu Ile Ser 
                405                 410                 415     


Gln Val Asp Ser Cys Ser Ser Gln Val Ser Gly Ile His Glu Met Met 
            420                 425                 430         


Gly Cys Ile Lys Arg Arg Val Asp His Leu Thr Glu Gln Cys Ser Ala 
        435                 440                 445             


His Lys Glu Tyr Ala Leu Lys Lys Gln Gln Leu Thr Ala Ser Val Glu 
    450                 455                 460                 


Gly Tyr Leu Arg Lys Val Glu Met Ser Ile Gln Lys Ile Ser Pro Val 
465                 470                 475                 480 


Leu Ser Asn Ala Met Asp Val Gly Ser Thr Arg Ser Glu Ser Glu Lys 
                485                 490                 495     


Ile Leu Asn Lys Tyr Leu Glu Leu Asp Ile Gln Ala Lys Glu Thr Ser 
            500                 505                 510         


His Glu Leu Glu Ala Ala Ala Lys Thr Met Met Glu Lys Asn Glu Phe 
        515                 520                 525             


Val Ser Asp Glu Met Val Ser Leu Ser Ser Lys Ala Arg Trp Leu Ala 
    530                 535                 540                 


Glu Glu Leu Asn Leu Phe Gly Gln Ser Ile Asp Tyr Arg Ser Gln Val 
545                 550                 555                 560 


Leu Gln Thr Tyr Val Ala Phe Leu Lys Ser Ser Glu Glu Val Glu Met 
                565                 570                 575     


Gln Phe Gln Ser Leu Lys Glu Phe Tyr Glu Thr Glu Ile Pro Gln Lys 
            580                 585                 590         


Glu Gln Asp Asp Ala Lys Ala Lys His Cys Ser Asp Ser Ala Glu Lys 
        595                 600                 605             


Gln Trp Gln Leu Phe Leu Lys Lys Ser Phe Ile Thr Gln Asp Leu Gly 
    610                 615                 620                 


Leu Glu Phe Leu Asn Leu Ile Asn Met Ala Lys Glu Asn Glu Ile Leu 
625                 630                 635                 640 


Asp Val Lys Asn Glu Val Tyr Leu Met Lys Asn Thr Met Glu Asn Gln 
                645                 650                 655     


Lys Ala Glu Arg Glu Glu Leu Ser Leu Leu Arg Leu Ala Trp Gln Leu 
            660                 665                 670         


Lys Ala Thr Glu Ser Lys Pro Gly Lys Gln Gln Trp Ala Ala Phe Lys 
        675                 680                 685             


Glu Gln Leu Lys Lys Thr Ser His Asn Leu Lys Leu Leu Gln Glu Ala 
    690                 695                 700                 


Leu Met Pro Val Ser Ala Leu Asp Leu Gly Gly Ser Leu Gln Phe Ile 
705                 710                 715                 720 


Leu Asp Leu Arg Gln Lys Trp Asn Asp Met Lys Pro Gln Phe Gln Gln 
                725                 730                 735     


Leu Asn Asp Glu Val Gln Tyr Ile Met Lys Glu Ser Glu Glu Leu Thr 
            740                 745                 750         


Gly Arg Gly Ala Pro Val Lys Glu Lys Ser Gln Gln Leu Lys Asp Leu 
        755                 760                 765             


Ile His Phe His Gln Lys Gln Lys Glu Arg Ile Gln Asp Tyr Glu Asp 
    770                 775                 780                 


Ile Leu Tyr Lys Val Val Gln Phe His Gln Val Lys Glu Glu Leu Gly 
785                 790                 795                 800 


Arg Leu Ile Lys Ser Arg Glu Leu Glu Phe Val Glu Gln Pro Lys Glu 
                805                 810                 815     


Leu Gly Asp Ala His Asp Val Gln Ile His Leu Arg Cys Ser Gln Glu 
            820                 825                 830         


Lys Gln Ala Arg Val Asp His Leu His Arg Leu Ala Leu Ser Leu Gly 
        835                 840                 845             


Val Asp Ile Ile Ser Ser Val Gln Arg Pro His Cys Ser Asn Val Ser 
    850                 855                 860                 


Ala Lys Asn Leu Gln Gln Gln Leu Glu Leu Leu Glu Glu Asp Ser Met 
865                 870                 875                 880 


Lys Trp Arg Ala Lys Ala Glu Glu Tyr Gly Arg Thr Leu Ser Arg Ser 
                885                 890                 895     


Val Glu Tyr Cys Ala Met Arg Asp Glu Ile Asn Glu Leu Lys Asp Ser 
            900                 905                 910         


Phe Lys Asp Ile Lys Lys Lys Phe Asn Asn Leu Lys Phe Asn Tyr Thr 
        915                 920                 925             


Lys Lys Asn Glu Lys Ser Arg Asn Leu Lys Ala Leu Lys Tyr Gln Ile 
    930                 935                 940                 


Gln Gln Val Asp Met Tyr Ala Glu Lys Met Gln Ala Leu Lys Arg Lys 
945                 950                 955                 960 


Met Glu Lys Val Ser Asn Lys Thr Ser Asp Ser Phe Leu Asn Tyr Pro 
                965                 970                 975     


Ser Asp Lys Val Asn Val Leu Leu Glu Val Met Lys Asp Leu Gln Lys 
            980                 985                 990         


His Val Asp Asp Phe Asp Lys Val  Val Thr Asp Tyr Lys  Lys Asn Leu 
        995                 1000                 1005             


Asp Leu  Thr Glu His Phe Gln  Glu Val Ile Glu Glu  Cys His Phe 
    1010                 1015                 1020             


Trp Tyr  Glu Asp Ala Ser Ala  Thr Val Val Arg Val  Gly Lys Tyr 
    1025                 1030                 1035             


Ser Thr  Glu Cys Lys Thr Lys  Glu Ala Val Lys Ile  Leu His Gln 
    1040                 1045                 1050             


Gln Phe  Asn Lys Phe Ile Ala  Pro Ser Val Pro Gln  Gln Glu Glu 
    1055                 1060                 1065             


Arg Ile  Gln Glu Ala Thr Asp  Leu Ala Gln His Leu  Tyr Gly Leu 
    1070                 1075                 1080             


Glu Glu  Gly Gln Lys Tyr Ile  Glu Lys Ile Val Thr  Lys His Lys 
    1085                 1090                 1095             


Glu Val  Leu Glu Ser Val Thr  Glu Leu Cys Glu Ser  Leu Thr Glu 
    1100                 1105                 1110             


Leu Glu  Glu Lys Leu Lys Gln  Gly Asp Val Leu Lys  Met Asn Pro 
    1115                 1120                 1125             


Asn Leu  Glu Asp Phe His Tyr  Asp Tyr Ile Asp Leu  Leu Lys Glu 
    1130                 1135                 1140             


Pro Ala  Lys Asn Lys Gln Thr  Ile Phe Asn Glu Glu  Arg Asn Lys 
    1145                 1150                 1155             


Gly Gln  Val Gln Val Ala Asp  Leu Leu Gly Ile Asn  Gly Thr Gly 
    1160                 1165                 1170             


Glu Glu  Arg Leu Pro Gln Asp  Leu Lys Val Ser Thr  Asp Lys Glu 
    1175                 1180                 1185             


Gly Gly  Val Gln Asp Leu Leu  Leu Pro Glu Asp Met  Leu Ser Gly 
    1190                 1195                 1200             


Glu Glu  Tyr Glu Cys Val Ser  Pro Asp Asp Ile Ser  Leu Pro Pro 
    1205                 1210                 1215             


Leu Pro  Gly Ser Pro Glu Ser  Pro Leu Ala Pro Ser  Asp Met Glu 
    1220                 1225                 1230             


Val Glu  Glu Pro Val Ser Ser  Ser Leu Ser Leu His  Ile Ser Ser 
    1235                 1240                 1245             


Tyr Gly  Val Gln Ala Gly Thr  Ser Ser Pro Gly Asp  Ala Gln Glu 
    1250                 1255                 1260             


Ser Val  Leu Pro Pro Pro Val  Ala Phe Ala Asp Ala  Cys Asn Asp 
    1265                 1270                 1275             


Lys Arg  Glu Thr Phe Ser Ser  His Phe Glu Arg Pro  Tyr Leu Gln 
    1280                 1285                 1290             


Phe Lys  Ala Glu Pro Pro Leu  Thr Ser Arg Gly Phe  Val Glu Lys 
    1295                 1300                 1305             


Ser Thr  Ala Leu His Arg Ile  Ser Ala Glu His Pro  Glu Ser Met 
    1310                 1315                 1320             


Met Ser  Glu Val His Glu Arg  Ala Leu Gln Gln His  Pro Gln Ala 
    1325                 1330                 1335             


Gln Gly  Gly Leu Leu Glu Thr  Arg Glu Lys Met His  Ala Asp Asn 
    1340                 1345                 1350             


Asn Phe  Thr Lys Thr Gln Asp  Arg Leu His Ala Ser  Ser Asp Ala 
    1355                 1360                 1365             


Phe Ser  Gly Leu Arg Phe Gln  Ser Gly Thr Ser Arg  Gly Tyr Gln 
    1370                 1375                 1380             


Arg Gln  Met Val Pro Arg Glu  Glu Ile Lys Ser Thr  Ser Ala Lys 
    1385                 1390                 1395             


Ser Ser  Val Val Ser Leu Ala  Asp Gln Ala Pro Asn  Phe Ser Arg 
    1400                 1405                 1410             


Leu Leu  Ser Asn Val Thr Val  Met Glu Gly Ser Pro  Val Thr Leu 
    1415                 1420                 1425             


Glu Val  Glu Val Thr Gly Phe  Pro Glu Pro Thr Leu  Thr Trp Tyr 
    1430                 1435                 1440             


Lys Lys  Gly Gln Lys Leu Ser  Ala Asp Gly His Leu  Gln Val Leu 
    1445                 1450                 1455             


His Lys  Glu Thr Arg His Ser  Val Phe Ile Pro Lys  Val Cys Lys 
    1460                 1465                 1470             


Ala Asp  Ala Gly Leu Tyr Val  Ala Arg Ala Gln Asn  Ser Ser Gly 
    1475                 1480                 1485             


Ala Leu  Ser Ser Asn Val Ile  Leu His Val Thr Gly  Asn Cys Arg 
    1490                 1495                 1500             


Leu Pro  Ile Thr Arg Val Asn  Trp Ile Thr Leu Cys  Val Val Tyr 
    1505                 1510                 1515             


Val Ser  Val Ser Leu Met Tyr  Trp Leu Leu Thr Gln  
    1520                 1525                 1530 


<210>  6372
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  6372

Met Ser Thr Val Lys Glu Ala Ala His Arg Leu Ser Lys Ser Glu Met 
1               5                   10                  15      


Ser Leu Tyr Ala Val Leu Asp Leu Lys Lys Gly Ala Ser Pro Glu Asp 
            20                  25                  30          


Phe Lys Lys Ser Tyr Ser His Ser Ala Leu Leu Pro His Pro Pro Phe 
        35                  40                  45              


Glu Tyr His Leu Gly Arg Lys Leu Ala Leu Arg Tyr His Pro Asp Lys 
    50                  55                  60                  


Asn Pro Gly Asn Ala Gln Ala Ala Glu Ile Phe Lys Glu Ile Asn Ala 
65                  70                  75                  80  


Ala His Ala Ile Leu Ser Asp Ser Lys Lys Arg Lys Ile Tyr Asp Gln 
                85                  90                  95      


His Gly Ser Leu Gly Ile Tyr Leu Tyr Asp His Phe Gly Glu Glu Gly 
            100                 105                 110         


Val Arg Tyr Tyr Phe Ile Leu Asn Ser Cys Trp Phe Lys Thr Leu Val 
        115                 120                 125             


Ile Leu Cys Thr Leu Leu Thr Cys Cys Cys Phe Cys Cys Cys Cys Cys 
    130                 135                 140                 


Phe Cys Cys Gly Ala Leu Lys Pro Pro Pro Glu Gln Asp Ser Gly Arg 
145                 150                 155                 160 


Lys Tyr Gln Gln Asn Val Gln Ser Gln Pro Pro Arg Ser Gly Ala Lys 
                165                 170                 175     


Cys Asp Phe Arg Ser Glu Glu Asn Ser Glu Asp Asp Phe 
            180                 185                 


<210>  6373
<211>  645
<212>  PRT
<213>  Homo sapiens

<400>  6373

Met Glu Arg Gln Ser Arg Val Met Ser Glu Lys Asp Glu Tyr Gln Phe 
1               5                   10                  15      


Gln His Gln Gly Ala Val Glu Leu Leu Val Phe Asn Phe Leu Leu Ile 
            20                  25                  30          


Leu Thr Ile Leu Thr Ile Trp Leu Phe Lys Asn His Arg Phe Arg Phe 
        35                  40                  45              


Leu His Glu Thr Gly Gly Ala Met Val Tyr Gly Leu Ile Met Gly Leu 
    50                  55                  60                  


Ile Leu Arg Tyr Ala Thr Ala Pro Thr Asp Ile Glu Ser Gly Thr Val 
65                  70                  75                  80  


Tyr Asp Cys Val Lys Leu Thr Phe Ser Pro Ser Thr Leu Leu Val Asn 
                85                  90                  95      


Ile Thr Asp Gln Val Tyr Glu Tyr Lys Tyr Lys Arg Glu Ile Ser Gln 
            100                 105                 110         


His Asn Ile Asn Pro His Gln Gly Asn Ala Ile Leu Glu Lys Met Thr 
        115                 120                 125             


Phe Asp Pro Glu Ile Phe Phe Asn Val Leu Leu Pro Pro Ile Ile Phe 
    130                 135                 140                 


His Ala Gly Tyr Ser Leu Lys Lys Arg His Phe Phe Gln Asn Leu Gly 
145                 150                 155                 160 


Ser Ile Leu Thr Tyr Ala Phe Leu Gly Thr Ala Ile Ser Cys Ile Val 
                165                 170                 175     


Ile Gly Leu Ile Met Tyr Gly Phe Val Lys Ala Met Ile His Ala Gly 
            180                 185                 190         


Gln Leu Lys Asn Gly Asp Phe His Phe Thr Asp Cys Leu Phe Phe Gly 
        195                 200                 205             


Ser Leu Met Ser Ala Thr Asp Pro Val Thr Val Leu Ala Ile Phe His 
    210                 215                 220                 


Glu Leu His Val Asp Pro Asp Leu Tyr Thr Leu Leu Phe Gly Glu Ser 
225                 230                 235                 240 


Val Leu Asn Asp Ala Val Ala Ile Val Leu Thr Tyr Ser Ile Ser Ile 
                245                 250                 255     


Tyr Ser Pro Lys Glu Asn Pro Asn Ala Phe Asp Ala Ala Ala Phe Phe 
            260                 265                 270         


Gln Ser Val Gly Asn Phe Leu Gly Ile Phe Ala Gly Ser Phe Ala Met 
        275                 280                 285             


Gly Ser Ala Tyr Ala Ile Ile Thr Ala Leu Leu Thr Lys Phe Thr Lys 
    290                 295                 300                 


Leu Cys Glu Phe Pro Met Leu Glu Thr Gly Leu Phe Phe Leu Leu Ser 
305                 310                 315                 320 


Trp Ser Ala Phe Leu Ser Ala Glu Ala Ala Gly Leu Thr Gly Ile Val 
                325                 330                 335     


Ala Val Leu Phe Cys Gly Val Thr Gln Ala His Tyr Thr Tyr Asn Asn 
            340                 345                 350         


Leu Ser Ser Asp Ser Lys Ile Arg Thr Lys Gln Leu Phe Glu Phe Met 
        355                 360                 365             


Asn Phe Leu Ala Glu Asn Val Ile Phe Cys Tyr Met Gly Leu Ala Leu 
    370                 375                 380                 


Phe Thr Phe Gln Asn His Ile Phe Asn Ala Leu Phe Ile Leu Gly Ala 
385                 390                 395                 400 


Phe Leu Ala Ile Phe Val Ala Arg Ala Cys Asn Ile Tyr Pro Leu Ser 
                405                 410                 415     


Phe Leu Leu Asn Leu Gly Arg Lys Gln Lys Ile Pro Trp Asn Phe Gln 
            420                 425                 430         


His Met Met Met Phe Ser Gly Leu Arg Gly Ala Ile Ala Phe Ala Leu 
        435                 440                 445             


Ala Ile Arg Asn Thr Glu Ser Gln Pro Lys Gln Met Met Phe Thr Thr 
    450                 455                 460                 


Thr Leu Leu Leu Val Phe Phe Thr Val Trp Val Phe Gly Gly Gly Thr 
465                 470                 475                 480 


Thr Pro Met Leu Thr Trp Leu Gln Ile Arg Val Gly Val Asp Leu Asp 
                485                 490                 495     


Glu Asn Leu Lys Glu Asp Pro Ser Ser Gln His Gln Glu Ala Asn Asn 
            500                 505                 510         


Leu Asp Lys Asn Met Thr Lys Ala Glu Ser Ala Arg Leu Phe Arg Met 
        515                 520                 525             


Trp Tyr Ser Phe Asp His Lys Tyr Leu Lys Pro Ile Leu Thr His Ser 
    530                 535                 540                 


Gly Pro Pro Leu Thr Thr Thr Leu Pro Glu Trp Cys Gly Pro Ile Ser 
545                 550                 555                 560 


Arg Leu Leu Thr Ser Pro Gln Ala Tyr Gly Glu Gln Leu Lys Glu Asp 
                565                 570                 575     


Asp Val Glu Cys Ile Val Asn Gln Asp Glu Leu Ala Ile Asn Tyr Gln 
            580                 585                 590         


Glu Gln Ala Ser Ser Pro Cys Ser Pro Pro Ala Arg Leu Gly Leu Asp 
        595                 600                 605             


Gln Lys Ala Ser Pro Gln Thr Pro Gly Lys Glu Asn Ile Tyr Glu Gly 
    610                 615                 620                 


Asp Leu Gly Leu Gly Gly Tyr Glu Leu Lys Leu Glu Gln Thr Leu Gly 
625                 630                 635                 640 


Gln Ser Gln Leu Asn 
                645 


<210>  6374
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  6374

Met Leu Met Leu Phe Val Phe Gly Val Leu Leu His Glu Val Ser Leu 
1               5                   10                  15      


Ser Gly Gln Asn Glu Ala Pro Pro Asn Thr His Ser Ile Pro Gly Glu 
            20                  25                  30          


Pro Leu Tyr Asn Tyr Ala Ser Ile Arg Leu Pro Glu Glu His Ile Pro 
        35                  40                  45              


Phe Phe Leu His Asn Asn Arg His Ile Ala Thr Val Cys Arg Lys Asp 
    50                  55                  60                  


Ser Leu Cys Pro Tyr Lys Lys His Leu Glu Lys Leu Lys Tyr Cys Trp 
65                  70                  75                  80  


Gly Tyr Glu Lys Ser Cys Lys Pro Glu Phe Arg Phe Gly Tyr Pro Val 
                85                  90                  95      


Cys Ser Tyr Val Asp Met Gly Trp Thr Asp Thr Leu Glu Ser Ala Glu 
            100                 105                 110         


Asp Ile Phe Trp Lys Gln Ala Asp Phe Gly Tyr Ala Arg Glu Arg Leu 
        115                 120                 125             


Glu Glu Met His Val Leu Cys Gln Pro Lys Glu Thr Ser Asp Ser Ser 
    130                 135                 140                 


Leu Val Cys Ser Arg Tyr Leu Gln Tyr Cys Arg Ala Thr Asn Leu Tyr 
145                 150                 155                 160 


Leu Asp Leu Arg Asn Ile Lys Arg Asn His Asp Arg Phe Lys Glu Asp 
                165                 170                 175     


Phe Phe Gln Ser Gly Glu Ile Gly Gly His Cys Lys Leu Asp Ile Arg 
            180                 185                 190         


Thr Leu Thr Ser Glu Gly Gln Arg Lys Ser Pro Leu Gln Ser Trp Phe 
        195                 200                 205             


Ala Glu Leu Gln Ser Tyr Thr Gln Leu Asn Phe Arg Pro Ile Glu Asp 
    210                 215                 220                 


Ala Lys Cys Asp Ile Val Ile Glu Lys Pro Thr Tyr Phe Met Lys Leu 
225                 230                 235                 240 


Asp Ala Gly Val Asn Met Tyr His His Phe Cys Asp Phe Ile Asn Leu 
                245                 250                 255     


Tyr Ile Thr Gln His Val Asn Asn Ser Phe Ser Thr Asp Val Tyr Ile 
            260                 265                 270         


Val Met Trp Asp Thr Asp Gly Lys Ile Arg Val Thr Ile Leu Ala Arg 
        275                 280                 285             


Ser Thr Glu Tyr Arg Lys Ile Leu Asn Gln Asn Glu Leu Val Asn Ala 
    290                 295                 300                 


Leu Lys Thr Val Ser Thr Phe Glu Val Gln Ile Val Asp Tyr Lys Tyr 
305                 310                 315                 320 


Arg Glu Leu Gly Phe Leu Asp Gln Leu Arg Ile Thr His Asn Thr Asp 
                325                 330                 335     


Ile Phe Ile Gly Met His Gly Ala Gly Leu Thr His Leu Leu Phe Leu 
            340                 345                 350         


Pro Asp Trp Ala Ala Val Phe Glu Leu Tyr Asn Cys Glu Asp Glu Arg 
        355                 360                 365             


Cys Tyr Leu Asp Leu Ala Arg Leu Arg Gly Val His Tyr Ile Thr Trp 
    370                 375                 380                 


Arg Arg Gln Asn Lys Val Phe Pro Gln Asp Lys Gly His His Pro Thr 
385                 390                 395                 400 


Leu Gly Glu His Pro Lys Phe Thr Asn Tyr Ser Phe Asp Val Glu Glu 
                405                 410                 415     


Phe Met Tyr Leu Val Leu Gln Ala Ala Asp His Val Leu Gln His Pro 
            420                 425                 430         


Lys Trp Pro Phe Lys Lys Lys His Asp Glu Leu 
        435                 440             


<210>  6375
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  6375

Met Lys Asp Ser Pro Phe Gln Val Thr Lys Leu Tyr Trp Leu Asn Glu 
1               5                   10                  15      


Lys Trp Asp Phe Ile Ala Ser Ala Ser Asp Met Ala Ala Glu Gln Gly 
            20                  25                  30          


Gln Ile Leu Val Ile Ala Thr Ala Ala Val Gly Gly Phe Thr Leu Leu 
        35                  40                  45              


Val Ile Leu Thr Leu Phe Phe Leu Ile Thr Gly Arg Cys Gln Trp Tyr 
    50                  55                  60                  


Ile Lys Ala Lys Met Lys Ser Glu Glu Lys Arg Arg Asn His Leu Gln 
65                  70                  75                  80  


Asn Gly His Leu Arg Phe Pro Gly Ile Lys Thr Tyr Ile Asp Pro Asp 
                85                  90                  95      


Thr Tyr Glu Asp Pro Ser Leu Ala Val His Glu Phe Ala Lys Glu Ile 
            100                 105                 110         


Asp Pro Ser Arg Ile Arg Ile Glu Arg Val Ile Gly Ala Gly Glu Phe 
        115                 120                 125             


Gly Glu Val Cys Ser Gly Arg Leu Lys Thr Pro Gly Lys Arg Glu Ile 
    130                 135                 140                 


Pro Val Ala Ile Lys Thr Leu Lys Gly Gly His Met Asp Arg Gln Arg 
145                 150                 155                 160 


Arg Asp Phe Leu Arg Glu Ala Ser Ile Met Gly Gln Phe Asp His Pro 
                165                 170                 175     


Asn Ile Ile Arg Leu Glu Gly Val Val Thr Lys Arg Ser Phe Pro Ala 
            180                 185                 190         


Ile Gly Val Glu Ala Phe Cys Pro Ser Phe Leu Arg Ala Gly Phe Leu 
        195                 200                 205             


Asn Ser Ile Gln Ala Pro His Pro Val Pro Gly Gly Gly Ser Leu Pro 
    210                 215                 220                 


Pro Arg Ile Pro Ala Gly Arg Pro Val Met Ile Val Val Glu Tyr Met 
225                 230                 235                 240 


Glu Asn Gly Ser Leu Asp Ser Phe Leu Arg Lys His Asp Gly His Phe 
                245                 250                 255     


Thr Val Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ser Gly Met 
            260                 265                 270         


Lys Tyr Leu Ser Asp Met Gly Tyr Val His Arg Asp Leu Ala Ala Arg 
        275                 280                 285             


Asn Ile Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly 
    290                 295                 300                 


Leu Ser Arg Val Leu Glu Asp Asp Pro Glu Ala Ala Tyr Thr Thr Thr 
305                 310                 315                 320 


Asp Leu Phe Gln Thr Leu Thr Leu Asn Leu Cys Tyr Ser Ala 
                325                 330                 


<210>  6376
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  6376

Met Ala Ala Gly Thr Ala Ala Arg Lys Ala Ala Pro Val Leu Glu Ala 
1               5                   10                  15      


Pro Pro Gln Gln Glu Gln Leu Ser His Thr Lys Leu Ser Ala Glu Asp 
            20                  25                  30          


Thr Trp Asn Leu Gln Gln Glu Arg Met Tyr Lys Met His Arg Gly His 
        35                  40                  45              


Asp Ser Met His Val Glu Met Ile Leu Ile Phe Leu Cys Val Leu Val 
    50                  55                  60                  


Ile Ala Gln Ile Val Leu Val Gln Trp Arg Gln Arg His Gly Arg Ser 
65                  70                  75                  80  


Tyr Asn Leu Val Thr Leu Leu Gln Met Trp Val Val Pro Leu Tyr Phe 
                85                  90                  95      


Thr Ile Lys Leu Tyr Trp Trp Arg Phe Leu Ser Met Trp Gly Met Phe 
            100                 105                 110         


Ser Val Ile Thr Ser Tyr Ile Leu Phe Arg Ala Thr Arg Lys Pro Leu 
        115                 120                 125             


Ser Gly Arg Thr Pro Arg Leu Val Tyr Lys Trp Phe Leu Leu Ile Tyr 
    130                 135                 140                 


Lys Leu Ser Tyr Ala Phe Gly Val Val Gly Tyr Leu Ala Ile Met Phe 
145                 150                 155                 160 


Thr Met Cys Gly Phe Asn Leu Phe Phe Lys Ile Lys Ala Arg Asp Ser 
                165                 170                 175     


Met Asp Phe Gly Ile Val Ser Leu Phe Tyr Gly Leu Tyr Tyr Gly Val 
            180                 185                 190         


Met Gly Arg Asp Phe Ala Glu Ile Cys Ser Asp Tyr Met Ala Ser Thr 
        195                 200                 205             


Ile Gly Phe Tyr Ser Val Ser Arg Leu Pro Thr Arg Ser Leu Ser Asp 
    210                 215                 220                 


Asn Ile Cys Ala Val Cys Gly Gln Lys Ile Ile Val Glu Leu Asp Glu 
225                 230                 235                 240 


Glu Gly Leu Ile Glu Asn Thr Tyr Gln Leu Ser Cys Asn His Val Phe 
                245                 250                 255     


His Glu Phe Cys Ile Arg Gly Trp Cys Ile Val Gly Lys Lys Gln Thr 
            260                 265                 270         


Cys Pro Tyr Cys Lys Glu Lys Val Asp Leu Lys Arg Met Ile Ser Asn 
        275                 280                 285             


Pro Trp Glu Arg Thr His Phe Leu Tyr Gly Gln Ile Leu Asp Trp Leu 
    290                 295                 300                 


Arg Tyr Leu Val Ala Trp Gln Pro Val Val Ile Gly Ile Val Gln Gly 
305                 310                 315                 320 


Ile Asn Tyr Ser Leu Gly Leu Glu 
                325             


<210>  6377
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  6377

Met Ala Pro Arg Pro Leu Gly Pro Leu Val Leu Ala Leu Gly Gly Ala 
1               5                   10                  15      


Ala Ala Val Leu Gly Ser Val Leu Phe Ile Leu Trp Lys Thr Tyr Phe 
            20                  25                  30          


Gly Arg Gly Arg Glu Arg Arg Trp Asp Arg Gly Glu Ala Trp Trp Gly 
        35                  40                  45              


Ala Glu Ala Ala Arg Leu Pro Glu Trp Asp Glu Trp Asp Pro Glu Asp 
    50                  55                  60                  


Glu Glu Asp Glu Glu Pro Ala Leu Glu Glu Leu Glu Gln Arg Glu Val 
65                  70                  75                  80  


Leu Val Leu Gly Leu Asp Gly Ala Gly Lys Ser Thr Phe Leu Arg Val 
                85                  90                  95      


Leu Ser Gly Lys Pro Pro Leu Glu Gly His Ile Pro Thr Trp Gly Phe 
            100                 105                 110         


Asn Ser Val Arg Leu Pro Thr Lys Asp Phe Glu Val Asp Leu Leu Glu 
        115                 120                 125             


Ile Gly Gly Ser Gln Asn Leu Arg Phe Tyr Trp Lys Glu Phe Val Ser 
    130                 135                 140                 


Glu Val Asp Val Leu Val Phe Val Val Asp Ser Ala Asp Arg Leu Arg 
145                 150                 155                 160 


Leu Pro Trp Ala Arg Gln Glu Leu His Lys Leu Leu Asp Lys Asp Pro 
                165                 170                 175     


Asp Leu Pro Val Val Val Val Ala Asn Lys Gln Asp Leu Ser Glu Ala 
            180                 185                 190         


Met Ser Met Gly Glu Leu Gln Arg Glu Leu Gly Leu Gln Ala Ile Asp 
        195                 200                 205             


Asn Gln Arg Glu Val Phe Leu Leu Ala Ala Ser Ile Ala Pro Ala Gly 
    210                 215                 220                 


Pro Thr Phe Glu Glu Pro Gly Thr Val His Ile Trp Lys Leu Leu Leu 
225                 230                 235                 240 


Glu Leu Leu Ser 
                


<210>  6378
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  6378

Met Val Pro Gly Ala Arg Gly Gly Gly Ala Leu Ala Arg Ala Ala Gly 
1               5                   10                  15      


Arg Gly Leu Leu Ala Leu Leu Leu Ala Val Ser Ala Pro Leu Arg Leu 
            20                  25                  30          


Gln Ala Glu Glu Leu Gly Asp Gly Cys Gly His Leu Val Thr Tyr Gln 
        35                  40                  45              


Asp Ser Gly Thr Met Thr Ser Lys Asn Tyr Pro Gly Thr Tyr Pro Asn 
    50                  55                  60                  


His Thr Val Cys Glu Lys Thr Ile Thr Val Pro Lys Gly Lys Arg Leu 
65                  70                  75                  80  


Ile Leu Arg Leu Gly Asp Leu Asp Ile Glu Ser Gln Thr Cys Ala Ser 
                85                  90                  95      


Asp Tyr Leu Leu Phe Thr Ser Ser Ser Asp Gln Tyr Gly Pro Tyr Cys 
            100                 105                 110         


Gly Ser Met Thr Val Pro Lys Glu Leu Leu Leu Asn Thr Ser Glu Val 
        115                 120                 125             


Thr Val Arg Phe Glu Ser Gly Ser His Ile Ser Gly Arg Gly Phe Leu 
    130                 135                 140                 


Leu Thr Tyr Ala Ser Ser Asp His Pro Asp Leu Ile Thr Cys Leu Glu 
145                 150                 155                 160 


Arg Ala Ser His Tyr Leu Lys Thr Glu Tyr Ser Lys Phe Cys Pro Ala 
                165                 170                 175     


Gly Cys Arg Asp Val Ala Gly Asp Ile Ser Gly Asn Met Val Asp Gly 
            180                 185                 190         


Tyr Arg Asp Thr Ser Leu Leu Cys Lys Ala Ala Ile His Ala Gly Ile 
        195                 200                 205             


Ile Ala Asp Glu Leu Gly Gly Gln Ile Ser Val Leu Gln Arg Lys Gly 
    210                 215                 220                 


Ile Ser Arg Tyr Glu Gly Ile Leu Ala Asn Gly Val Leu Ser Arg Asp 
225                 230                 235                 240 


Gly Ser Leu Ser Asp Lys Arg Phe Leu Phe Thr Ser Asn Gly Cys Ser 
                245                 250                 255     


Arg Ser Leu Ser Phe Glu Pro Asp Gly Gln Ile Arg Ala Ser Ser Ser 
            260                 265                 270         


Trp Gln Ser Val Asn Glu Ser Gly Asp Gln Val His Trp Ser Pro Gly 
        275                 280                 285             


Gln Ala Arg Leu Gln Asp Gln Gly Pro Ser Trp Ala Ser Gly Asp Ser 
    290                 295                 300                 


Ser Asn Asn His Lys Pro Arg Glu Trp Leu Glu Ile Asp Leu Gly Glu 
305                 310                 315                 320 


Lys Lys Lys Ile Thr Gly Ile Arg Thr Thr Gly Ser Thr Gln Ser Asn 
                325                 330                 335     


Phe Asn Phe Tyr Val Lys Ser Phe Val Met Asn Phe Lys Asn Asn Asn 
            340                 345                 350         


Ser Lys Trp Lys Thr Tyr Lys Gly Ile Val Asn Asn Glu Glu Lys Val 
        355                 360                 365             


Phe Gln Gly Asn Ser Asn Phe Arg Asp Pro Val Gln Asn Asn Phe Ile 
    370                 375                 380                 


Pro Pro Ile Val Ala Arg Tyr Val Arg Val Val Pro Gln Thr Trp His 
385                 390                 395                 400 


Gln Arg Ile Ala Leu Lys Val Glu Leu Ile Gly Cys Gln Ile Thr Gln 
                405                 410                 415     


Gly Asn Asp Ser Leu Val Trp Arg Lys Thr Ser Gln Ser Thr Ser Val 
            420                 425                 430         


Ser Thr Lys Lys Glu Asp Glu Thr Ile Thr Arg Pro Ile Pro Ser Glu 
        435                 440                 445             


Glu Thr Ser Thr Gly Ile Asn Ile Thr Thr Val Ala Ile Pro Leu Val 
    450                 455                 460                 


Leu Leu Val Val Leu Val Phe Ala Gly Met Gly Ile Phe Ala Ala Phe 
465                 470                 475                 480 


Arg Lys Lys Lys Lys Lys Gly Ser Pro Tyr Gly Ser Ala Glu Ala Gln 
                485                 490                 495     


Lys Thr Asp Cys Trp Lys Gln Ile Lys Tyr Pro Phe Ala Arg His Gln 
            500                 505                 510         


Ser Ala Glu Phe Thr Ile Ser Tyr Asp Asn Glu Lys Glu Met Thr Gln 
        515                 520                 525             


Lys Leu Asp Leu Ile Thr Ser Asp Met Ala Gly 
    530                 535                 


<210>  6379
<211>  924
<212>  PRT
<213>  Homo sapiens

<400>  6379

Met Val Ser Arg Met Gly Trp Gly Gly Arg Arg Arg Arg Leu Gly Arg 
1               5                   10                  15      


Trp Gly Asp Leu Gly Pro Gly Ser Val Pro Leu Leu Pro Met Pro Leu 
            20                  25                  30          


Pro Pro Pro Pro Pro Pro Ser Cys Arg Gly Pro Gly Gly Gly Arg Ile 
        35                  40                  45              


Ser Ile Phe Ser Leu Ser Pro Ala Pro His Thr Arg Ser Ser Pro Ser 
    50                  55                  60                  


Ser Phe Ser Pro Pro Thr Ala Gly Pro Pro Cys Ser Val Leu Gln Gly 
65                  70                  75                  80  


Thr Gly Ala Ser Gln Ser Cys His Ser Ala Leu Pro Ile Pro Ala Thr 
                85                  90                  95      


Pro Pro Thr Gln Ala Gln Pro Ala Met Thr Pro Ala Ser Ala Ser Pro 
            100                 105                 110         


Ser Trp Gly Ser His Ser Thr Pro Pro Leu Ala Pro Ala Thr Pro Thr 
        115                 120                 125             


Pro Ser Gln Gln Cys Pro Gln Asp Ser Pro Gly Leu Arg Val Gly Pro 
    130                 135                 140                 


Leu Ile Pro Glu Gln Asp Tyr Glu Arg Leu Glu Asp Cys Asp Pro Glu 
145                 150                 155                 160 


Gly Ser Gln Asp Ser Pro Ile His Gly Glu Glu Gln Gln Pro Leu Leu 
                165                 170                 175     


His Val Pro Glu Gly Leu Arg Gly Ser Trp His His Ile Gln Asn Leu 
            180                 185                 190         


Asp Ser Phe Phe Thr Lys Ile Tyr Ser Tyr His Gln Arg Asn Gly Phe 
        195                 200                 205             


Ala Cys Ile Leu Leu Glu Asp Val Phe Gln Leu Gly Gln Phe Ile Phe 
    210                 215                 220                 


Ile Val Thr Phe Thr Thr Phe Leu Leu Arg Cys Val Asp Tyr Asn Val 
225                 230                 235                 240 


Leu Phe Ala Asn Gln Pro Ser Asn His Thr Arg Pro Gly Pro Phe His 
                245                 250                 255     


Ser Lys Val Thr Leu Ser Asp Ala Ile Leu Pro Ser Ala Gln Cys Ala 
            260                 265                 270         


Glu Arg Ile Arg Ser Ser Pro Leu Leu Val Leu Leu Leu Val Leu Ala 
        275                 280                 285             


Ala Gly Phe Trp Leu Val Gln Leu Leu Arg Ser Val Cys Asn Leu Phe 
    290                 295                 300                 


Ser Tyr Trp Asp Ile Gln Val Phe Tyr Arg Glu Ala Leu His Ile Pro 
305                 310                 315                 320 


Pro Glu Glu Leu Ser Ser Val Pro Trp Ala Glu Val Gln Ser Arg Leu 
                325                 330                 335     


Leu Ala Leu Gln Arg Ser Gly Gly Leu Cys Val Gln Pro Arg Pro Leu 
            340                 345                 350         


Thr Glu Leu Asp Ile His His Arg Ile Leu Arg Tyr Thr Asn Tyr Gln 
        355                 360                 365             


Val Ala Leu Ala Asn Lys Gly Leu Leu Pro Ala Arg Cys Pro Leu Pro 
    370                 375                 380                 


Trp Gly Gly Ser Ala Ala Phe Leu Ser Arg Gly Leu Ala Leu Asn Val 
385                 390                 395                 400 


Asp Leu Leu Leu Phe Arg Gly Pro Phe Ser Leu Phe Arg Gly Gly Trp 
                405                 410                 415     


Glu Leu Pro His Ala Tyr Lys Arg Ser Asp Gln Arg Gly Ala Leu Ala 
            420                 425                 430         


Ala Arg Trp Gly Arg Thr Val Leu Leu Leu Ala Ala Leu Asn Leu Ala 
        435                 440                 445             


Leu Ser Pro Leu Val Leu Ala Trp Gln Val Leu His Val Phe Tyr Ser 
    450                 455                 460                 


His Val Glu Leu Leu Arg Arg Glu Pro Gly Ala Leu Gly Ala Arg Gly 
465                 470                 475                 480 


Trp Ser Arg Leu Ala Arg Leu Gln Leu Arg His Phe Asn Glu Leu Pro 
                485                 490                 495     


His Glu Leu Arg Ala Arg Leu Ala Arg Ala Tyr Arg Pro Ala Ala Ala 
            500                 505                 510         


Phe Leu Arg Thr Ala Ala Pro Pro Ala Pro Leu Arg Thr Leu Leu Ala 
        515                 520                 525             


Arg Gln Leu Val Phe Phe Ala Gly Ala Leu Phe Ala Ala Leu Leu Val 
    530                 535                 540                 


Leu Thr Val Tyr Asp Glu Asp Val Leu Ala Val Glu His Val Leu Thr 
545                 550                 555                 560 


Ala Met Thr Ala Leu Gly Val Thr Ala Thr Val Ala Arg Ser Phe Ile 
                565                 570                 575     


Pro Glu Glu Gln Cys Gln Gly Arg Ala Pro Gln Leu Leu Leu Gln Thr 
            580                 585                 590         


Ala Leu Ala His Met His Tyr Leu Pro Glu Glu Pro Gly Pro Gly Gly 
        595                 600                 605             


Arg Asp Arg Ala Tyr Arg Gln Met Ala Gln Leu Leu Gln Tyr Arg Ala 
    610                 615                 620                 


Val Ser Leu Leu Glu Glu Leu Leu Ser Pro Leu Leu Thr Pro Leu Phe 
625                 630                 635                 640 


Leu Leu Phe Trp Phe Arg Pro Arg Ala Leu Glu Ile Ile Asp Phe Phe 
                645                 650                 655     


His His Phe Thr Val Asp Val Ala Gly Val Gly Asp Ile Cys Ser Phe 
            660                 665                 670         


Ala Leu Met Asp Val Lys Arg His Gly His Pro Gln Trp Leu Ser Ala 
        675                 680                 685             


Gly Gln Thr Glu Ala Ser Leu Ser Gln Arg Ala Glu Asp Gly Lys Thr 
    690                 695                 700                 


Glu Leu Ser Leu Met Arg Phe Ser Leu Ala His Pro Leu Trp Arg Pro 
705                 710                 715                 720 


Pro Gly His Ser Ser Lys Phe Leu Gly His Leu Trp Gly Arg Val Gln 
                725                 730                 735     


Gln Asp Ala Ala Ala Trp Gly Ala Thr Ser Ala Arg Gly Pro Ser Thr 
            740                 745                 750         


Pro Gly Val Leu Ser Asn Cys Thr Ser Pro Leu Pro Glu Ala Phe Leu 
        755                 760                 765             


Ala Asn Leu Phe Val His Pro Leu Leu Pro Pro Arg Asp Leu Ser Pro 
    770                 775                 780                 


Thr Ala Pro Cys Pro Ala Ala Ala Thr Ala Ser Leu Leu Ala Ser Ile 
785                 790                 795                 800 


Ser Arg Ile Ala Gln Asp Pro Ser Ser Val Ser Pro Gly Gly Thr Gly 
                805                 810                 815     


Gly Gln Lys Leu Ala Gln Leu Pro Glu Leu Ala Ser Ala Glu Met Ser 
            820                 825                 830         


Leu His Val Ile Tyr Leu His Gln Leu His Gln Gln Gln Gln Gln Gln 
        835                 840                 845             


Glu Pro Trp Gly Glu Ala Ala Ala Ser Ile Leu Ser Arg Pro Cys Ser 
    850                 855                 860                 


Ser Pro Ser Gln Pro Pro Ser Pro Asp Glu Glu Lys Pro Ser Trp Ser 
865                 870                 875                 880 


Ser Asp Gly Ser Ser Pro Ala Ser Ser Pro Arg Gln Gln Trp Gly Thr 
                885                 890                 895     


Gln Lys Ala Arg Asn Leu Phe Pro Gly Gly Phe Gln Val Thr Thr Asp 
            900                 905                 910         


Thr Gln Lys Glu Pro Asp Arg Ala Ser Cys Thr Asp 
        915                 920                 


<210>  6380
<211>  641
<212>  PRT
<213>  Homo sapiens

<400>  6380

Met Ala Ala Lys Ser Asp Gly Gly Gly Val Gly Val Gly Phe Ala Gln 
1               5                   10                  15      


Leu His Asn Leu Asp Glu Ala Val Gly Ser Gly Gly Glu Glu Asp Gly 
            20                  25                  30          


Glu Pro Gly Gly Gly Gly Cys Gly Gly Gly Gly Asp Gly Ser Glu Pro 
        35                  40                  45              


Gly Glu Ser Ser Ser Met His Ile Cys His Cys Cys Asn Thr Ser Ser 
    50                  55                  60                  


Cys Tyr Trp Gly Cys Arg Ser Ala Cys Leu Arg Ser Leu Leu Gly Arg 
65                  70                  75                  80  


Lys Pro Arg Arg Ser Ala Ala Ala Asp Gly Gly Asp Gln Pro Leu Gln 
                85                  90                  95      


Pro Pro Ala Ala Pro Gly Ala Gly Arg Gln Pro Pro Thr Pro Ser Ala 
            100                 105                 110         


Ala Arg Pro Glu Pro Pro Pro Pro Gln Val Glu Arg Pro Trp Leu Asp 
        115                 120                 125             


Cys Leu Trp Ile Val Leu Ala Leu Leu Val Phe Phe Gly Asp Val Gly 
    130                 135                 140                 


Thr Asp Leu Trp Leu Ala Leu Asp Tyr Tyr Arg Lys Gly Asp Tyr Val 
145                 150                 155                 160 


Tyr Phe Gly Leu Thr Leu Phe Phe Val Leu Val Pro Ser Leu Leu Val 
                165                 170                 175     


Gln Ser Leu Ser Phe Arg Trp Phe Val Gln Asp Tyr Thr Gly Gly Gly 
            180                 185                 190         


Leu Gly Ala Val Glu Gly Leu Thr Ser Arg Gly Pro Pro Met Met Gly 
        195                 200                 205             


Ala Gly Tyr Val His Gly Ala Ala Arg Gly Gly Pro Gly Val Arg Val 
    210                 215                 220                 


Ser Pro Thr Pro Gly Ala Gln Arg Leu Cys Arg Leu Ser Val Trp Ile 
225                 230                 235                 240 


Trp Gln Ser Val Ile His Leu Leu Gln Met Gly Gln Val Trp Arg Tyr 
                245                 250                 255     


Ile Arg Thr Met Tyr Leu Gly Ile Gln Ser Gln Arg Arg Lys Glu His 
            260                 265                 270         


Gln Arg Arg Phe Tyr Trp Ala Met Met Tyr Glu Tyr Ala Asp Val Asn 
        275                 280                 285             


Met Leu Arg Leu Leu Glu Thr Phe Leu Glu Ser Ala Pro Gln Leu Val 
    290                 295                 300                 


Leu Gln Leu Tyr Ile Met Leu Gln Lys Asn Ser Ala Glu Thr Leu Pro 
305                 310                 315                 320 


Cys Val Ser Ser Val Thr Ser Leu Met Ser Leu Ala Trp Val Leu Ala 
                325                 330                 335     


Ser Tyr His Lys Leu Leu Arg Asp Ser Arg Asp Asp Lys Lys Ser Met 
            340                 345                 350         


Ser Tyr Arg Gly Ala Ile Ile Gln Val Phe Trp Arg Leu Phe Thr Ile 
        355                 360                 365             


Ser Ser Arg Val Ile Ser Phe Ala Leu Phe Ala Ser Ile Phe Gln Leu 
    370                 375                 380                 


Tyr Phe Gly Ile Phe Val Val Val His Trp Cys Ala Met Ala Phe Trp 
385                 390                 395                 400 


Ile Ile His Gly Gly Thr Asp Phe Cys Met Ser Lys Trp Glu Glu Ile 
                405                 410                 415     


Leu Phe Asn Met Val Val Gly Ile Val Tyr Ile Phe Cys Trp Phe Asn 
            420                 425                 430         


Val Lys Glu Gly Arg Thr Arg Tyr Arg Met Phe Ala Tyr Tyr Thr Ile 
        435                 440                 445             


Val Leu Thr Glu Asn Ala Ala Leu Thr Phe Leu Trp Tyr Phe Tyr Arg 
    450                 455                 460                 


Asp Pro Glu Thr Thr Asp Ser Tyr Ala Val Pro Ala Leu Cys Cys Val 
465                 470                 475                 480 


Phe Ile Ser Phe Val Ala Gly Ile Ala Met Met Leu Leu Tyr Tyr Gly 
                485                 490                 495     


Val Leu His Pro Thr Gly Pro Arg Ala Lys Ile Leu Ala Ser Ser Cys 
            500                 505                 510         


Cys Ala Glu Leu Leu Trp Gly Ile Pro Leu Pro Pro Asp Val Glu Pro 
        515                 520                 525             


Met Ala Pro Glu Ile Pro Gly Tyr Arg Gly Thr Gln Val Thr Pro Thr 
    530                 535                 540                 


Arg Ala Val Thr Glu Gln Gln Glu Asp Leu Thr Ala Asp Thr Cys Leu 
545                 550                 555                 560 


Pro Val Phe Gln Val Arg Pro Met Gly Pro Pro Thr Pro Leu Gly Arg 
                565                 570                 575     


Pro Tyr Leu Pro Glu Gly Pro Leu Ile Lys Ile Asp Met Pro Arg Lys 
            580                 585                 590         


Arg Tyr Pro Ala Trp Asp Ala His Phe Val Asp Arg Arg Leu Arg Arg 
        595                 600                 605             


Thr Ile Asn Ile Leu Gln Tyr Val Thr Pro Thr Ala Val Gly Ile Arg 
    610                 615                 620                 


Tyr Arg Asp Gly Pro Leu Leu Tyr Glu Leu Leu Gln Tyr Glu Ser Ser 
625                 630                 635                 640 


Leu 
    


<210>  6381
<211>  1285
<212>  PRT
<213>  Homo sapiens

<400>  6381

Met Ala Leu Ala Arg Pro Gly Thr Pro Asp Pro Gln Ala Leu Ala Ser 
1               5                   10                  15      


Val Leu Leu Leu Leu Leu Trp Ala Pro Ala Leu Ser Leu Leu Ala Gly 
            20                  25                  30          


Thr Val Pro Ser Glu Pro Pro Ser Ala Cys Ala Ser Asp Pro Cys Ala 
        35                  40                  45              


Pro Gly Thr Glu Cys Gln Ala Thr Glu Ser Gly Gly Tyr Thr Cys Gly 
    50                  55                  60                  


Pro Met Glu Pro Arg Gly Cys Ala Thr Gln Pro Cys His His Gly Ala 
65                  70                  75                  80  


Leu Cys Val Pro Gln Gly Pro Asp Pro Thr Gly Phe Arg Cys Tyr Cys 
                85                  90                  95      


Val Pro Gly Phe Gln Gly Pro Arg Cys Glu Leu Asp Ile Asp Glu Cys 
            100                 105                 110         


Ala Ser Arg Pro Cys His His Gly Ala Thr Cys Arg Asn Leu Ala Asp 
        115                 120                 125             


Arg Tyr Glu Cys His Cys Pro Leu Gly Tyr Ala Gly Val Thr Cys Glu 
    130                 135                 140                 


Met Glu Val Asp Glu Cys Ala Ser Ala Pro Cys Leu His Gly Gly Ser 
145                 150                 155                 160 


Cys Leu Asp Gly Val Gly Ser Phe Arg Cys Val Cys Ala Pro Gly Tyr 
                165                 170                 175     


Gly Gly Thr Arg Cys Gln Leu Asp Leu Asp Glu Cys Gln Ser Gln Pro 
            180                 185                 190         


Cys Ala His Gly Gly Thr Cys His Asp Leu Val Asn Gly Phe Arg Cys 
        195                 200                 205             


Asp Cys Ala Gly Thr Gly Tyr Glu Gly Thr His Cys Glu Arg Glu Val 
    210                 215                 220                 


Leu Glu Cys Ala Ser Ala Pro Cys Glu His Asn Ala Ser Cys Leu Glu 
225                 230                 235                 240 


Gly Leu Gly Ser Phe Arg Cys Leu Cys Trp Pro Gly Tyr Ser Gly Glu 
                245                 250                 255     


Leu Cys Glu Val Asp Glu Asp Glu Cys Ala Ser Ser Pro Cys Gln His 
            260                 265                 270         


Gly Gly Arg Cys Leu Gln Arg Ser Asp Pro Ala Leu Tyr Gly Gly Val 
        275                 280                 285             


Gln Ala Ala Phe Pro Gly Ala Phe Ser Phe Arg His Ala Ala Gly Phe 
    290                 295                 300                 


Leu Cys His Cys Pro Pro Gly Phe Glu Gly Ala Asp Cys Gly Val Glu 
305                 310                 315                 320 


Val Asp Glu Cys Ala Ser Arg Pro Cys Leu Asn Gly Gly His Cys Gln 
                325                 330                 335     


Asp Leu Pro Asn Gly Phe Gln Cys His Cys Pro Asp Gly Tyr Ala Gly 
            340                 345                 350         


Pro Thr Cys Glu Glu Asp Val Asp Glu Cys Leu Ser Asp Pro Cys Leu 
        355                 360                 365             


His Gly Gly Thr Cys Ser Asp Thr Val Ala Gly Tyr Ile Cys Arg Cys 
    370                 375                 380                 


Pro Glu Thr Trp Gly Gly Arg Asp Cys Ser Val Gln Leu Thr Gly Cys 
385                 390                 395                 400 


Gln Gly His Thr Cys Pro Leu Ala Ala Thr Cys Ile Pro Ile Phe Glu 
                405                 410                 415     


Ser Gly Val His Ser Tyr Val Cys His Cys Pro Pro Gly Thr His Gly 
            420                 425                 430         


Pro Phe Cys Gly Gln Asn Thr Thr Phe Ser Val Met Ala Gly Ser Pro 
        435                 440                 445             


Ile Gln Ala Ser Val Pro Ala Gly Gly Pro Leu Gly Leu Ala Leu Arg 
    450                 455                 460                 


Phe Arg Thr Thr Leu Pro Ala Gly Thr Leu Ala Thr Arg Asn Asp Thr 
465                 470                 475                 480 


Lys Glu Ser Leu Glu Leu Ala Leu Val Ala Ala Thr Leu Gln Ala Thr 
                485                 490                 495     


Leu Trp Ser Tyr Ser Thr Thr Val Leu Val Leu Arg Leu Pro Asp Leu 
            500                 505                 510         


Ala Leu Asn Asp Gly His Trp His Gln Val Glu Val Val Leu His Leu 
        515                 520                 525             


Ala Thr Leu Glu Leu Arg Leu Trp His Glu Gly Cys Pro Ala Arg Leu 
    530                 535                 540                 


Cys Val Ala Ser Gly Pro Val Ala Leu Ala Ser Thr Ala Ser Ala Thr 
545                 550                 555                 560 


Pro Leu Pro Ala Gly Ile Ser Ser Ala Gln Leu Gly Asp Ala Thr Phe 
                565                 570                 575     


Ala Gly Cys Leu Gln Asp Val Arg Val Asp Gly His Leu Leu Leu Pro 
            580                 585                 590         


Glu Asp Leu Gly Glu Asn Val Leu Leu Gly Cys Glu Arg Arg Glu Gln 
        595                 600                 605             


Cys Arg Pro Leu Pro Cys Val His Gly Gly Ser Cys Val Asp Leu Trp 
    610                 615                 620                 


Thr His Phe Arg Cys Asp Cys Ala Arg Pro His Arg Gly Pro Thr Cys 
625                 630                 635                 640 


Ala Asp Glu Ile Pro Ala Ala Thr Phe Gly Leu Gly Gly Ala Pro Ser 
                645                 650                 655     


Ser Ala Ser Phe Leu Leu Gln Glu Leu Pro Gly Pro Asn Leu Thr Val 
            660                 665                 670         


Ser Phe Leu Leu Arg Thr Arg Glu Ser Ala Gly Leu Leu Leu Gln Phe 
        675                 680                 685             


Ala Asn Asp Ser Ala Ala Gly Leu Thr Val Phe Leu Ser Glu Gly Arg 
    690                 695                 700                 


Ile Arg Ala Glu Val Pro Gly Ser Pro Ala Val Val Leu Pro Gly Arg 
705                 710                 715                 720 


Trp Asp Asp Gly Leu Arg His Leu Val Met Leu Ser Phe Gly Pro Asp 
                725                 730                 735     


Gln Leu Gln Asp Leu Gly Gln His Val His Val Gly Gly Arg Leu Leu 
            740                 745                 750         


Ala Ala Asp Ser Gln Pro Trp Gly Gly Pro Phe Arg Gly Cys Leu Gln 
        755                 760                 765             


Asp Leu Arg Leu Asp Gly Cys His Leu Pro Phe Phe Pro Leu Pro Leu 
    770                 775                 780                 


Asp Asn Ser Ser Gln Pro Ser Glu Leu Gly Gly Arg Gln Ser Trp Asn 
785                 790                 795                 800 


Leu Thr Ala Gly Cys Val Ser Glu Asp Met Cys Ser Pro Asp Pro Cys 
                805                 810                 815     


Phe Asn Gly Gly Thr Cys Leu Val Thr Trp Asn Asp Phe His Cys Thr 
            820                 825                 830         


Cys Pro Ala Asn Phe Thr Gly Pro Thr Cys Ala Gln Gln Leu Trp Cys 
        835                 840                 845             


Pro Gly Gln Pro Cys Leu Pro Pro Ala Thr Cys Glu Glu Val Pro Asp 
    850                 855                 860                 


Gly Phe Val Cys Val Ala Glu Ala Thr Phe Arg Glu Gly Pro Pro Ala 
865                 870                 875                 880 


Ala Phe Ser Gly His Asn Ala Ser Ser Gly Arg Leu Leu Gly Gly Leu 
                885                 890                 895     


Ser Leu Ala Phe Arg Thr Arg Asp Ser Glu Ala Trp Leu Leu Arg Ala 
            900                 905                 910         


Ala Ala Gly Ala Leu Glu Gly Val Trp Leu Ala Val Arg Asn Gly Ser 
        915                 920                 925             


Leu Ala Gly Gly Val Arg Gly Gly His Gly Leu Pro Gly Ala Val Leu 
    930                 935                 940                 


Pro Ile Pro Gly Pro Arg Val Ala Asp Gly Ala Trp His Arg Val Arg 
945                 950                 955                 960 


Leu Ala Met Glu Arg Pro Ala Ala Thr Thr Ser Arg Trp Leu Leu Trp 
                965                 970                 975     


Leu Asp Gly Ala Ala Thr Pro Val Ala Leu Arg Gly Leu Ala Ser Asp 
            980                 985                 990         


Leu Gly Phe Leu Gln Gly Pro Gly  Ala Val Arg Ile Leu  Leu Ala Glu 
        995                 1000                 1005             


Asn Phe  Thr Gly Cys Leu Gly  Arg Val Ala Leu Gly  Gly Leu Pro 
    1010                 1015                 1020             


Leu Pro  Leu Ala Arg Pro Arg  Pro Gly Ala Ala Pro  Gly Ala Arg 
    1025                 1030                 1035             


Glu His  Phe Ala Ser Trp Pro  Gly Thr Pro Ala Pro  Ile Leu Gly 
    1040                 1045                 1050             


Cys Arg  Gly Ala Pro Val Cys  Ala Pro Ser Pro Cys  Leu His Asp 
    1055                 1060                 1065             


Gly Ala  Cys Arg Asp Leu Phe  Asp Ala Phe Ala Cys  Ala Cys Gly 
    1070                 1075                 1080             


Pro Gly  Trp Glu Gly Pro Arg  Cys Glu Ala His Val  Asp Pro Cys 
    1085                 1090                 1095             


His Ser  Ala Pro Cys Ala Arg  Gly Arg Cys His Thr  His Pro Asp 
    1100                 1105                 1110             


Gly Arg  Phe Glu Cys Arg Cys  Pro Pro Gly Phe Gly  Gly Pro Arg 
    1115                 1120                 1125             


Cys Arg  Leu Pro Val Pro Ser  Lys Glu Cys Ser Leu  Asn Val Thr 
    1130                 1135                 1140             


Cys Leu  Asp Gly Ser Pro Cys  Glu Gly Gly Ser Pro  Ala Ala Asn 
    1145                 1150                 1155             


Cys Ser  Cys Leu Glu Gly Leu  Ala Gly Gln Arg Cys  Gln Val Pro 
    1160                 1165                 1170             


Thr Leu  Pro Cys Glu Ala Asn  Pro Cys Leu Asn Gly  Gly Thr Cys 
    1175                 1180                 1185             


Arg Ala  Ala Gly Gly Val Ser  Glu Cys Ile Cys Asn  Ala Arg Phe 
    1190                 1195                 1200             


Ser Gly  Gln Phe Cys Glu Val  Ala Lys Gly Leu Pro  Leu Pro Leu 
    1205                 1210                 1215             


Pro Phe  Pro Leu Leu Glu Val  Ala Val Pro Ala Ala  Cys Ala Cys 
    1220                 1225                 1230             


Leu Leu  Leu Leu Leu Leu Gly  Leu Leu Ser Gly Ile  Leu Ala Ala 
    1235                 1240                 1245             


Arg Lys  Arg Arg Gln Ser Glu  Gly Thr Tyr Ser Pro  Ser Gln Gln 
    1250                 1255                 1260             


Glu Val  Ala Gly Ala Arg Leu  Glu Met Asp Ser Val  Leu Lys Val 
    1265                 1270                 1275             


Pro Pro  Glu Glu Arg Leu Ile  
    1280                 1285 


<210>  6382
<211>  1132
<212>  PRT
<213>  Homo sapiens

<400>  6382

Met Gln Met Val Pro Ser Leu Pro Pro Ala Ser Glu Cys Ala Gly Glu 
1               5                   10                  15      


Glu Lys Arg Val Gly Thr Arg Thr Val Phe Val Gly Asn His Pro Val 
            20                  25                  30          


Ser Glu Thr Glu Ala Tyr Ile Ala Gln Arg Phe Cys Asp Asn Arg Ile 
        35                  40                  45              


Val Ser Ser Lys Tyr Thr Leu Trp Asn Phe Leu Pro Lys Asn Leu Phe 
    50                  55                  60                  


Glu Gln Phe Arg Arg Ile Ala Asn Phe Tyr Phe Leu Ile Ile Phe Leu 
65                  70                  75                  80  


Val Gln Val Thr Val Asp Thr Pro Thr Ser Pro Val Thr Ser Gly Leu 
                85                  90                  95      


Pro Leu Phe Phe Val Ile Thr Val Thr Ala Ile Lys Gln Gly Tyr Glu 
            100                 105                 110         


Asp Trp Leu Arg His Arg Ala Asp Asn Glu Val Asn Lys Ser Thr Val 
        115                 120                 125             


Tyr Ile Ile Glu Asn Ala Lys Arg Val Arg Lys Glu Ser Glu Lys Ile 
    130                 135                 140                 


Lys Val Gly Asp Val Val Glu Val Gln Ala Asp Glu Thr Phe Pro Cys 
145                 150                 155                 160 


Asp Leu Ile Leu Leu Ser Ser Cys Thr Thr Asp Gly Thr Cys Tyr Val 
                165                 170                 175     


Thr Thr Ala Ser Leu Asp Gly Glu Ser Asn Cys Lys Thr His Tyr Ala 
            180                 185                 190         


Val Arg Asp Thr Ile Ala Leu Cys Thr Ala Glu Ser Ile Asp Thr Leu 
        195                 200                 205             


Arg Ala Ala Ile Glu Cys Glu Gln Pro Gln Pro Asp Leu Tyr Lys Phe 
    210                 215                 220                 


Val Gly Arg Ile Asn Ile Tyr Ser Asn Ser Leu Glu Ala Val Ala Arg 
225                 230                 235                 240 


Ser Leu Gly Pro Glu Asn Leu Leu Leu Lys Gly Ala Thr Leu Lys Asn 
                245                 250                 255     


Thr Glu Lys Ile Tyr Gly Val Ala Val Tyr Thr Gly Met Glu Thr Lys 
            260                 265                 270         


Met Ala Leu Asn Tyr Gln Gly Lys Ser Gln Lys Arg Ser Ala Val Glu 
        275                 280                 285             


Lys Ser Ile Asn Ala Phe Leu Ile Val Tyr Leu Phe Ile Leu Leu Thr 
    290                 295                 300                 


Lys Ala Ala Val Cys Thr Thr Leu Lys Tyr Val Trp Gln Ser Thr Pro 
305                 310                 315                 320 


Tyr Asn Asp Glu Pro Trp Tyr Asn Gln Lys Thr Gln Lys Glu Arg Glu 
                325                 330                 335     


Thr Leu Lys Val Leu Lys Met Phe Thr Asp Phe Leu Ser Phe Met Val 
            340                 345                 350         


Leu Phe Asn Phe Ile Ile Pro Val Ser Met Tyr Val Thr Val Glu Met 
        355                 360                 365             


Gln Lys Phe Leu Gly Ser Phe Phe Ile Ser Trp Asp Lys Asp Phe Tyr 
    370                 375                 380                 


Asp Glu Glu Ile Asn Glu Gly Ala Leu Val Asn Thr Ser Asp Leu Asn 
385                 390                 395                 400 


Glu Glu Leu Gly Gln Val Asp Tyr Val Phe Thr Asp Lys Thr Gly Thr 
                405                 410                 415     


Leu Thr Glu Asn Ser Met Glu Phe Ile Glu Cys Cys Ile Asp Gly His 
            420                 425                 430         


Lys Tyr Lys Gly Val Thr Gln Glu Val Asp Gly Leu Ser Gln Thr Asp 
        435                 440                 445             


Gly Thr Leu Thr Tyr Phe Asp Lys Val Asp Lys Asn Arg Glu Glu Leu 
    450                 455                 460                 


Phe Leu Arg Ala Leu Cys Leu Cys His Thr Val Glu Ile Lys Thr Asn 
465                 470                 475                 480 


Asp Ala Val Asp Gly Ala Thr Glu Ser Ala Glu Leu Thr Tyr Ile Ser 
                485                 490                 495     


Ser Ser Pro Asp Glu Ile Ala Leu Val Lys Gly Ala Lys Arg Tyr Gly 
            500                 505                 510         


Phe Thr Phe Leu Gly Asn Arg Asn Gly Tyr Met Arg Val Glu Asn Gln 
        515                 520                 525             


Arg Lys Glu Ile Glu Glu Tyr Glu Leu Leu His Thr Leu Asn Phe Asp 
    530                 535                 540                 


Ala Val Arg Arg Arg Met Ser Val Ile Val Lys Thr Gln Glu Gly Asp 
545                 550                 555                 560 


Ile Leu Leu Phe Cys Lys Gly Ala Asp Ser Ala Val Phe Pro Arg Val 
                565                 570                 575     


Gln Asn His Glu Ile Glu Leu Thr Lys Val His Val Glu Arg Asn Ala 
            580                 585                 590         


Met Asp Gly Tyr Arg Thr Leu Cys Val Ala Phe Lys Glu Ile Ala Pro 
        595                 600                 605             


Asp Asp Tyr Glu Arg Ile Asn Arg Gln Leu Ile Glu Ala Lys Met Ala 
    610                 615                 620                 


Leu Gln Asp Arg Glu Glu Lys Met Glu Lys Val Phe Asp Asp Ile Glu 
625                 630                 635                 640 


Thr Asn Met Asn Leu Ile Gly Ala Thr Ala Val Glu Asp Lys Leu Gln 
                645                 650                 655     


Asp Gln Ala Ala Glu Thr Ile Glu Ala Leu His Ala Ala Gly Leu Lys 
            660                 665                 670         


Val Trp Val Leu Thr Gly Asp Lys Met Glu Thr Ala Lys Ser Thr Cys 
        675                 680                 685             


Tyr Ala Cys Arg Leu Phe Gln Thr Asn Thr Glu Leu Leu Glu Leu Thr 
    690                 695                 700                 


Thr Lys Thr Ile Glu Glu Ser Glu Arg Lys Glu Asp Arg Leu His Glu 
705                 710                 715                 720 


Leu Leu Ile Glu Tyr Arg Lys Lys Leu Leu His Glu Phe Pro Lys Ser 
                725                 730                 735     


Thr Arg Ser Phe Lys Lys Ala Trp Thr Glu His Gln Glu Tyr Gly Leu 
            740                 745                 750         


Ile Ile Asp Gly Ser Thr Leu Ser Leu Ile Leu Asn Ser Ser Gln Asp 
        755                 760                 765             


Ser Ser Ser Asn Asn Tyr Lys Ser Ile Phe Leu Gln Ile Cys Met Lys 
    770                 775                 780                 


Cys Thr Ala Val Leu Cys Cys Arg Met Ala Pro Leu Gln Lys Ala Gln 
785                 790                 795                 800 


Ile Val Arg Met Val Lys Asn Leu Lys Gly Ser Pro Ile Thr Leu Ser 
                805                 810                 815     


Ile Gly Asp Gly Ala Asn Asp Val Ser Met Ile Leu Glu Ser His Val 
            820                 825                 830         


Gly Ile Gly Ile Lys Gly Lys Glu Gly Arg Gln Ala Ala Arg Asn Ser 
        835                 840                 845             


Asp Tyr Ser Val Pro Lys Phe Lys His Leu Lys Lys Leu Leu Leu Ala 
    850                 855                 860                 


His Gly His Leu Tyr Tyr Val Arg Ile Ala His Leu Val Gln Tyr Phe 
865                 870                 875                 880 


Phe Tyr Lys Asn Leu Cys Phe Ile Leu Pro Gln Phe Leu Tyr Gln Phe 
                885                 890                 895     


Phe Cys Gly Phe Ser Gln Gln Pro Leu Tyr Asp Ala Ala Tyr Leu Thr 
            900                 905                 910         


Met Tyr Asn Ile Cys Phe Thr Ser Leu Pro Ile Leu Ala Tyr Ser Leu 
        915                 920                 925             


Leu Glu Gln His Ile Asn Ile Asp Thr Leu Thr Ser Asp Pro Arg Leu 
    930                 935                 940                 


Tyr Met Lys Ile Ser Gly Asn Ala Met Leu Gln Leu Gly Pro Phe Leu 
945                 950                 955                 960 


Tyr Trp Thr Phe Leu Ala Ala Phe Glu Gly Thr Val Phe Phe Phe Gly 
                965                 970                 975     


Thr Tyr Phe Leu Phe Gln Thr Ala Ser Leu Glu Glu Asn Gly Lys Val 
            980                 985                 990         


Tyr Gly Asn Trp Thr Phe Gly Thr  Ile Val Phe Thr Val  Leu Val Phe 
        995                 1000                 1005             


Thr Val  Thr Leu Lys Leu Ala  Leu Asp Thr Arg Phe  Trp Thr Trp 
    1010                 1015                 1020             


Ile Asn  His Phe Val Ile Trp  Gly Ser Leu Ala Phe  Tyr Val Phe 
    1025                 1030                 1035             


Phe Ser  Phe Phe Trp Gly Gly  Ile Ile Trp Pro Phe  Leu Lys Gln 
    1040                 1045                 1050             


Gln Arg  Met Tyr Phe Val Phe  Ala Gln Met Leu Ser  Ser Val Ser 
    1055                 1060                 1065             


Thr Trp  Leu Ala Ile Ile Leu  Leu Ile Phe Ile Ser  Leu Phe Pro 
    1070                 1075                 1080             


Glu Ile  Leu Leu Ile Val Leu  Lys Asn Val Arg Arg  Arg Ser Ala 
    1085                 1090                 1095             


Arg Arg  Asn Leu Ser Cys Arg  Arg Ala Ser Asp Ser  Leu Ser Ala 
    1100                 1105                 1110             


Arg Pro  Ser Val Arg Pro Leu  Leu Leu Arg Thr Phe  Ser Asp Glu 
    1115                 1120                 1125             


Ser Asn  Val Leu 
    1130         


<210>  6383
<211>  3187
<212>  PRT
<213>  Homo sapiens

<400>  6383

Met Asn Thr Gln Lys Gly Ser Leu Thr Ile Asn Val His Arg Gly Ser 
1               5                   10                  15      


Leu Ala Met Ser Ile Gln Arg Gly Ser Leu Val Pro Arg Asp Met Asp 
            20                  25                  30          


Ser Ser Gly Arg Asp Met Gln Leu Arg Val Ile Pro Ala Glu Val Lys 
        35                  40                  45              


Phe Leu Asp Thr Met Ala Gly Arg Val Tyr Arg Leu Pro Ile Thr Val 
    50                  55                  60                  


His Asn Ile Cys Arg Trp Asn Gln Lys Ile Arg Phe Lys Glu Pro Val 
65                  70                  75                  80  


Lys Pro Gln Phe Lys Leu Met Leu Thr Ser Leu Asp Lys Glu Leu Ala 
                85                  90                  95      


Ser Gly Leu Gln Met Thr Ala Met Val Glu Tyr His Pro Asp Lys Asp 
            100                 105                 110         


Glu Asp Thr Phe Asp Arg Leu Leu Ile Ser Ile Glu Asn Lys Thr Thr 
        115                 120                 125             


Glu Ile Pro Leu Ile Gly Leu Ile Pro Ser Cys Gln Leu Glu Ile Glu 
    130                 135                 140                 


Ser Val Val Asn Phe Gly Thr Leu Val Ala Asn Ser Lys Val Tyr Ser 
145                 150                 155                 160 


Lys Glu Ile Thr Ile Thr Asn His Gly Lys Ala Pro Gly Ile Phe Lys 
                165                 170                 175     


Ala Glu Tyr His Gly Gln Leu Pro Ile Leu Ile Phe Pro Thr Ser Gly 
            180                 185                 190         


Ile Val Asp Ala Lys Ser Ser Met Val Ile Lys Val Asp Phe Cys Ala 
        195                 200                 205             


Asp Gln Pro Arg Ile Val Asp Glu Glu Ala Ile Val Ile Leu Gln Gly 
    210                 215                 220                 


Gln Pro Glu Met Leu Leu Ser Ile Lys Ala His Val Val Glu Gln Ile 
225                 230                 235                 240 


Ile Glu Leu Leu Ser Met Ser Ser Asp Arg Arg Leu Glu Cys Ile His 
                245                 250                 255     


Phe Gly Pro Val Phe Phe Gly Ser Ser Lys Ile Lys His Ala Arg Val 
            260                 265                 270         


Tyr Asn Asn Ser Pro Glu Pro Ile Asn Trp Val Ala Ile Ile Gln Asp 
        275                 280                 285             


Asp Ala Val Gly Glu Glu Leu Gly Thr Asp Ile Gln Gln Arg Thr Asp 
    290                 295                 300                 


Ile Ala Leu Asn Asn Leu Thr Tyr Ile Arg Lys Ile Lys Asn Ile Asp 
305                 310                 315                 320 


Thr Thr Ile Ile Ile Ser Cys Leu Pro Asn Glu Gly Thr Leu Gln Pro 
                325                 330                 335     


Tyr Gln Lys Thr Val Ile Thr Phe Cys Phe Thr Pro Lys Leu Met Ala 
            340                 345                 350         


Val Gly Lys Lys Asp Ile Gly Pro Ser Tyr Arg Gln Asp Tyr Ala Leu 
        355                 360                 365             


Phe Leu Arg Phe Glu Ser Val Gly Ser Lys Asp Gly Phe Leu Arg Asp 
    370                 375                 380                 


Asp Asp Tyr Lys Thr Ile Lys Ser Glu Arg Phe Gln Lys Val Glu Leu 
385                 390                 395                 400 


Ala Leu Thr Gly Thr Gly Leu Pro Val Leu Leu Gln Phe Asp Pro Gly 
                405                 410                 415     


Pro Val Leu Asn Phe Lys Pro Cys Phe Met Gly Glu Arg Ser Glu Ile 
            420                 425                 430         


Gln Cys Ile Ile Lys Asn Gln Cys Glu Leu Leu Pro Val Thr Tyr His 
        435                 440                 445             


Phe Lys Lys Thr Ala Asn Phe Glu Ile Asp Pro Glu Lys Gly Lys Ile 
    450                 455                 460                 


Thr Gly Gly Gly Met Val Asp Val Met Cys Ser Phe Val Pro His Gln 
465                 470                 475                 480 


Leu Gly Val Phe Lys Val Lys Gln Met Ile Glu Ile Ile Gly Leu Val 
                485                 490                 495     


Ala Glu Glu Asp Leu Gln Ser Leu Ser Val Lys Ser Phe His His Val 
            500                 505                 510         


Tyr Leu Ala Phe Asn Ser Ile Cys Lys Ala Ser Thr Lys Lys Val Val 
        515                 520                 525             


Met Lys Phe Asp Pro Gly Ile Leu Pro Ser Ile Arg Asn Pro Thr Gly 
    530                 535                 540                 


Lys Phe Val Val Lys Asp Leu Ala Lys Arg Lys Asn Tyr Ala Pro Val 
545                 550                 555                 560 


Ala Met Leu Gln Ser Ala Met Thr Arg Thr His Asn His Arg Ser Cys 
                565                 570                 575     


Glu Glu Pro Val Lys Asp Met Leu Leu Ala Phe Pro Asn Asp Arg Ala 
            580                 585                 590         


Ala Thr Ile Arg Ser Lys Asp His His Lys His Phe Arg Pro Ile Phe 
        595                 600                 605             


Thr Lys Val Pro Arg Phe Asn Tyr Val Asn His Asp Phe Ala Tyr Thr 
    610                 615                 620                 


Thr Phe Glu Lys Gln Gln Lys Lys Leu His Glu Asn Tyr Tyr Ala Met 
625                 630                 635                 640 


Tyr Leu Lys Tyr Leu Arg Ser Val Arg Leu Gln Lys Lys Gln Ala Glu 
                645                 650                 655     


Arg Glu Arg Met Tyr Ser Tyr Asp Asp Thr Asp Ile Gly Leu Glu Pro 
            660                 665                 670         


Gly Ser Gly Leu Lys Ser Pro Ser Leu Ser Glu Ala Glu Ile Glu Glu 
        675                 680                 685             


Glu Leu Ser Ser Ala Ala Asn Ser Ile Arg Ala Asn Arg Leu Leu Thr 
    690                 695                 700                 


Thr Arg Gly Ile Ala Ser Gln Glu Glu Glu Ser Val Arg Arg Lys Val 
705                 710                 715                 720 


Leu Lys Gly Leu Lys Ser Glu Pro Ser Thr Pro Gln Glu Lys His Asp 
                725                 730                 735     


Cys Ser Leu Met Leu Thr Pro Lys Gln Ile His Gln Val Ile Val Gly 
            740                 745                 750         


Pro Ser Val Leu Asn Phe Gly Asn Ile Cys Val Asn Ser Pro Asn Thr 
        755                 760                 765             


His Leu Leu His Val Ile Asn Met Leu Pro Met His Val Leu Leu Gln 
    770                 775                 780                 


Leu Asp Thr Asp Leu Glu Glu Leu Gln Lys Thr Asn Gln Phe Ser Tyr 
785                 790                 795                 800 


Val Ile Leu Pro Thr Ser Ser Thr Tyr Ile Ser Met Val Phe Asp Ser 
                805                 810                 815     


Pro Thr Ile Gly Lys Phe Trp Lys Ser Phe Thr Phe Thr Val Asn Asn 
            820                 825                 830         


Val Pro Ser Gly His Ile Leu Val Val Ala Val Val Gln Pro Val Thr 
        835                 840                 845             


Leu Glu Leu Ser Ser Asn Glu Leu Val Leu Arg Pro Arg Gly Phe Phe 
    850                 855                 860                 


Met Lys Thr Cys Phe Arg Gly Thr Val Arg Leu Tyr Asn Arg Gln Asn 
865                 870                 875                 880 


Cys Cys Ala Gln Phe Gln Trp Gln Pro Val Asn Thr Gly Arg Gly Ile 
                885                 890                 895     


Ala Phe Ser Ile Cys Pro Ala Lys Gly Thr Val Glu Ala Tyr Ser Ser 
            900                 905                 910         


Leu Glu Cys Glu Val Thr Trp Gln Gln Gly Phe Ser Ser Pro Glu Glu 
        915                 920                 925             


Gly Glu Phe Ile Leu His Val Phe Gln Gly Asn Ala Leu Lys Leu Lys 
    930                 935                 940                 


Cys Val Ala His Leu Gly Arg Thr Lys Val Leu Leu Leu Gln Pro Arg 
945                 950                 955                 960 


Ile Leu Phe Ser Asn Cys Pro Gln Gly Leu Thr Thr Trp Arg Lys Ala 
                965                 970                 975     


Ile Leu Gln Asn Val Gly Gln Asn His Ala Tyr Phe Lys Val Cys Ser 
            980                 985                 990         


Gln Ser Leu Leu Pro Ile Ile Asn  Ile Ile Pro Ser Gln  Gly Ile Val 
        995                 1000                 1005             


Pro Phe  Gly Gly Ile Thr Val  Leu Asn Ile Ser Cys  Lys Pro Thr 
    1010                 1015                 1020             


Val Ala  Glu Lys Phe Asp Thr  Arg Ala Lys Val Ser  Ile Arg His 
    1025                 1030                 1035             


Ala Asn  Val Ile Asp Leu Arg  Ile Gly Gly Ser Ala  Glu Ile Ala 
    1040                 1045                 1050             


Asp Val  Glu Ile Asn Pro Asp  Val Phe Asn Phe Ser  Gly Ala Tyr 
    1055                 1060                 1065             


Ile Gly  Gly Thr Gln Ile Ile  Pro Phe Val Ile Lys  Asn Lys Gly 
    1070                 1075                 1080             


Ile Thr  Arg Ala Arg Val Glu  Phe Asn Leu Lys Asp  Phe Pro Asp 
    1085                 1090                 1095             


Phe Ser  Met Asp Leu Lys Asp  Lys Ser Glu Glu Phe  Lys Asp Pro 
    1100                 1105                 1110             


Ala Val  Pro Tyr Ile Tyr Ser  Leu Glu Leu Glu Glu  Asn Thr Ser 
    1115                 1120                 1125             


Leu Glu  Cys Ser Ile Thr Phe  Ser Pro Lys Glu Val  Thr Val Val 
    1130                 1135                 1140             


Glu Phe  Ile Ile Gln Val Gln  Ile Asn Phe Phe Glu  Ser Ser Lys 
    1145                 1150                 1155             


Leu Tyr  Thr Lys Tyr Leu Ser  Ser Ser Pro Ser Asn  Pro Lys Thr 
    1160                 1165                 1170             


Val Pro  Leu Ile Arg Pro Cys  Tyr Val Gln Ala Thr  Ala Leu Gln 
    1175                 1180                 1185             


Ser Pro  Leu Asn Leu Ser Ser  Thr Lys Phe Val Phe  Glu Ile Pro 
    1190                 1195                 1200             


Leu His  Glu Met Asn Pro Asn  Asn Lys Val Thr Lys  Thr Gln Asn 
    1205                 1210                 1215             


Leu Val  Leu Tyr Asn Ile Thr  Lys His His Val Thr  Trp Thr Leu 
    1220                 1225                 1230             


Asp Leu  Ser Asn Thr Gly Lys  Leu Phe Lys Asp Gly  Thr Phe Lys 
    1235                 1240                 1245             


Phe Ser  Val Leu Asn Gly Ile  Leu Arg Pro Asn Glu  Lys Tyr Asn 
    1250                 1255                 1260             


Val Ser  Ile Ser Phe Cys Pro  Asn Arg Pro Gly Thr  Tyr Thr Ala 
    1265                 1270                 1275             


Asp Ile  Pro Met Leu Leu Asn  Tyr Ile Pro Val Cys  Tyr Lys Ile 
    1280                 1285                 1290             


Leu His  Leu Thr Gly Glu Val  Lys Ser Pro Glu Leu  Leu Phe Asp 
    1295                 1300                 1305             


Pro Pro  Phe Ile Phe Phe Thr  Pro Val Pro Leu Asp  Ile Thr Thr 
    1310                 1315                 1320             


Val Met  Asp Ile Asn Ile Leu  Pro Gln Asn Tyr Phe  Arg Asn Ser 
    1325                 1330                 1335             


Thr Leu  Cys Val Gln Ile Pro  Thr Val Arg Leu Leu  Asp Gly Glu 
    1340                 1345                 1350             


Glu Ile  His Pro Leu Ser Val  Lys Phe Pro Lys Gly  Arg Val Ile 
    1355                 1360                 1365             


Pro Gly  Ser His Ser Gly Ile  Asn Asn Lys Leu Thr  Cys His Leu 
    1370                 1375                 1380             


Ser Phe  Lys Ser Ser Lys Pro  Val Ser Phe Phe Thr  Asn Leu Leu 
    1385                 1390                 1395             


Phe Cys  Asp Asp Arg Lys Asn  Trp Phe Ser Leu Pro  Val Thr Ala 
    1400                 1405                 1410             


Thr Ala  Glu Asn Cys Ile Leu  Thr Ile Tyr Pro Tyr  Met Ala Ile 
    1415                 1420                 1425             


His Leu  Asp Lys Gln Asn Ile  Ile Leu Lys Asn Asp  Lys Asp Glu 
    1430                 1435                 1440             


Tyr Leu  Lys Lys Thr Arg Asp  Gly Val Leu Pro Pro  Tyr Gln Asp 
    1445                 1450                 1455             


Ala Lys  Pro Pro Ser Pro Ala  Ser Ile Lys Lys Thr  Tyr Thr Thr 
    1460                 1465                 1470             


Ser Lys  Phe Asn Asp Ala Glu  Pro Ala Lys Gly Asn  Leu Phe Ile 
    1475                 1480                 1485             


Gly Val  Glu Val Leu Pro Glu  Asn Leu His Leu Asp  Glu Ser Glu 
    1490                 1495                 1500             


Thr Ser  Glu Glu Asp His Gly  Ser Leu Glu Lys Glu  Lys Tyr Glu 
    1505                 1510                 1515             


Gln Phe  Leu Ser Leu Glu Glu  Gly Thr Lys Ala His  Tyr Phe Phe 
    1520                 1525                 1530             


Glu Lys  Val Val Asn Ala Ala  Gln Thr Trp Phe Ser  Leu Phe Gly 
    1535                 1540                 1545             


Trp Pro  Glu Gly Pro His Ser  Phe Ser Ile Pro Glu  Thr Ile Arg 
    1550                 1555                 1560             


Arg Asp  Val Tyr Lys Met Gln  Phe Tyr Ser Ser Thr  Ser Pro Pro 
    1565                 1570                 1575             


Gln Lys  Phe Ser Arg Gln Asn  Asp Phe Ser Lys Tyr  Asn Lys Thr 
    1580                 1585                 1590             


Ile Tyr  Asp Val Leu Leu His  Leu Ser Gly Lys Met  Pro Pro Gly 
    1595                 1600                 1605             


Ile Asn  Ser Ser Gln Ser Leu  Pro Val Asp Asn His  Glu Lys Arg 
    1610                 1615                 1620             


Val Ile  Gln Leu His Leu Gln  His Ser Ser Leu Leu  Asp Phe Leu 
    1625                 1630                 1635             


Asn Ala  Gln Gly Gly Cys Ile  Ser His Val Leu Pro  Glu Phe Leu 
    1640                 1645                 1650             


Leu Glu  Pro Glu Asp Tyr Lys  Arg Trp Ile Glu Ile  Met Ser Ser 
    1655                 1660                 1665             


Thr Asn  Thr Met Pro Val Ser  Ser Cys Thr Pro Lys  Lys Lys Cys 
    1670                 1675                 1680             


Ser Ile  Val Ile Glu Met Ser  Lys Phe Glu Ala Trp  Ser Lys Arg 
    1685                 1690                 1695             


Ala Trp  Thr Asp Val Phe Leu  Gln Ile Tyr Lys Val  Leu Val Leu 
    1700                 1705                 1710             


Ser Arg  Val Val Pro Tyr Cys  Ser Asn Asn Met Pro  Pro Ile Cys 
    1715                 1720                 1725             


Val Gln  Asn Thr Pro Lys Val  Asn Pro Cys Phe Ala  Ser Ser Asn 
    1730                 1735                 1740             


Ile Tyr  Ser Asp Ser Glu Arg  Ile Leu Leu Ser Trp  Met Asn Ile 
    1745                 1750                 1755             


Asn Tyr  Glu Asn Thr Arg His  Val Ile Trp Lys Asn  Cys His Lys 
    1760                 1765                 1770             


Asp Val  Ile Pro Ser Glu Arg  Trp Ile Val Asn Phe  Asp Lys Asp 
    1775                 1780                 1785             


Leu Ser  Asp Gly Leu Val Phe  Ala Thr Gln Leu Gly  Ala Tyr Cys 
    1790                 1795                 1800             


Pro Phe  Leu Ile Glu Ser His  Phe Ile Asn Met Tyr  Thr Arg Pro 
    1805                 1810                 1815             


Lys Ser  Pro Glu Glu Tyr Leu  His Asn Cys Leu Ile  Ile Val Asn 
    1820                 1825                 1830             


Thr Leu  Tyr Glu Ile Asp Phe  Asp Val Glu Ile Gln  Ala Thr Asp 
    1835                 1840                 1845             


Ile Cys  Asp Pro Asn Pro Ile  Leu Met Leu Met Leu  Cys Val Tyr 
    1850                 1855                 1860             


Met Tyr  Glu Arg Leu Pro Thr  Tyr Leu Pro Lys Lys  Val Val Ser 
    1865                 1870                 1875             


Phe Glu  Cys Thr Leu His Asp  Thr Val Leu Asn Lys  Ile Leu Leu 
    1880                 1885                 1890             


Lys Asn  Ser Ser Ser Arg Asn  Leu Val Tyr Asn Ala  Arg Ile Val 
    1895                 1900                 1905             


Gly Arg  Asp Ala Ala Asp Phe  Ser Leu Ser Gln Lys  Gly Asn Val 
    1910                 1915                 1920             


Val Thr  Ile Ser Pro Arg Asn  Glu Ile Asn Val Thr  Leu Lys Phe 
    1925                 1930                 1935             


Thr Ser  Arg Phe Ile Arg Pro  Ala Glu Ala Ser Leu  Leu Leu Ile 
    1940                 1945                 1950             


Ser Lys  Pro Lys Asn Ala Val  Arg Gly Ile Thr Met  Thr Phe Ala 
    1955                 1960                 1965             


Leu Lys  Gly Lys Val Leu Asp  Phe Lys Ala Ile Asp  Ile Ile Lys 
    1970                 1975                 1980             


Cys Glu  Ser Pro Cys Tyr Gln  Phe Gln Glu Val Thr  Val Asn Val 
    1985                 1990                 1995             


Lys Asn  Pro Phe His Thr Ala  Gly Asp Phe Ser Val  Ile Leu Val 
    2000                 2005                 2010             


Glu Ser  Ser Thr Phe Val Ser  Ser Pro Thr Lys Leu  Thr Glu Ser 
    2015                 2020                 2025             


Arg Gln  Tyr Pro Lys His Asp  Asp Asp Met Ser Ser  Ser Gly Ser 
    2030                 2035                 2040             


Asp Thr  Asp Gln Gly Cys Ser  Asp Ser Pro Asn Val  Leu His Thr 
    2045                 2050                 2055             


Ser Ile  Lys Ser Thr Phe Ile  Arg Glu Phe Phe Cys  Ser Met His 
    2060                 2065                 2070             


Thr Val  His Leu Gly Val Lys  Gly Thr Ser Ser Leu  Glu Leu Arg 
    2075                 2080                 2085             


Phe Leu  Pro Phe Asn Met His  Val Arg Tyr Cys Val  Ile Ile Leu 
    2090                 2095                 2100             


Ser Asn  Lys Lys Ile Gly Gln  Leu Ile Tyr Val Ala  Glu Gly Lys 
    2105                 2110                 2115             


Gly Met  Thr Pro Leu Pro Ser  Ser Cys Leu Pro Met  Asn Thr Ser 
    2120                 2125                 2130             


Ser Ser  Pro Val Tyr Tyr Ser  Thr Thr Arg Glu Glu  Gly Pro Asn 
    2135                 2140                 2145             


Lys Lys  Tyr Pro Val Leu Tyr  Leu Lys Cys Lys Pro  Tyr Gln Ile 
    2150                 2155                 2160             


Leu Tyr  Val Asp Leu Lys Leu  Pro Met Thr Asn Glu  Ala Lys Glu 
    2165                 2170                 2175             


Lys Ala  Leu Ala Phe Ala Ala  Gln Gln Gln Met Ser  Ser Ile Glu 
    2180                 2185                 2190             


Tyr Glu  Arg Arg Leu Ile Thr  Gly Thr Leu Glu Ser  Ser Ser Ile 
    2195                 2200                 2205             


Arg Val  Ala Ile Ala Leu Leu  Gly Leu Thr Lys Ile  Glu Thr Leu 
    2210                 2215                 2220             


Met Leu  Phe Arg Ile Ser Lys  Leu Arg Lys Pro Lys  Thr Val Ser 
    2225                 2230                 2235             


Tyr Thr  Thr Glu Val Ser Leu  Pro Lys Tyr Phe Tyr  Ile Pro Glu 
    2240                 2245                 2250             


Lys Ile  Ser Ile Pro Trp Ile  Pro Glu Pro Gln Val  Ile Lys Leu 
    2255                 2260                 2265             


Ser Lys  Ala Lys Ala Ser Asp  Gly Ser Val Pro Leu  Pro Leu Gln 
    2270                 2275                 2280             


Phe Leu  Pro Leu Gln Ser Gly  Arg Tyr Pro Cys Lys  Ile Leu Leu 
    2285                 2290                 2295             


Lys Ser  Arg Tyr Asp Val Arg  Ala Tyr Tyr Val Glu  Gly Ile Val 
    2300                 2305                 2310             


Asn Glu  Glu Gln Pro Glu Ala  Lys Phe Glu Phe Glu  Thr Pro Ala 
    2315                 2320                 2325             


Phe Glu  Ala Leu Thr Gln Asn  Ile Pro Ile Lys Asn  Gln Thr Asn 
    2330                 2335                 2340             


Asp Lys  Trp Thr Phe Gln Val  Thr Ile Glu Gly Glu  Trp Phe Tyr 
    2345                 2350                 2355             


Gly Pro  Val Asp Leu His Val  Gly Pro Asp Glu Ile  Val Glu Tyr 
    2360                 2365                 2370             


Pro Leu  Thr Phe Lys Pro Ile  Phe Glu Cys Val Ile  Thr Gly Lys 
    2375                 2380                 2385             


Leu Ile  Leu Gln Asn Glu Val  Asp Gly Arg Glu His  Ile Phe Asp 
    2390                 2395                 2400             


Ile Lys  Gly Val Gly Lys Lys  Pro Ser Ala Leu Glu  His Ile Thr 
    2405                 2410                 2415             


Val Glu  Cys Gln Val Gly Asn  Val Thr Gln Lys His  Ile Thr Leu 
    2420                 2425                 2430             


Pro His  Phe Thr Asn Thr Ala  Leu Thr Phe Lys Val  Thr Ala Asp 
    2435                 2440                 2445             


Leu Pro  Ile Val Trp Gly Asn  Pro Gln Ile Thr Val  Tyr Pro Tyr 
    2450                 2455                 2460             


Lys Glu  Ile Leu Tyr Leu Ile  His Val Arg Pro Trp  Lys Arg Gly 
    2465                 2470                 2475             


Ile Leu  Lys Gly Thr Ile Thr  Phe Ser Thr Thr Arg  Arg Cys Thr 
    2480                 2485                 2490             


Thr Arg  Arg Lys His Asp Asp  Tyr Glu Glu Asp Thr  Asp Gln Asp 
    2495                 2500                 2505             


Gln Ala  Leu Ser Cys Leu Asp  Ser Ile Thr Glu Gln  Ser Ser Ile 
    2510                 2515                 2520             


Leu Asp  Asp Ala Asp Thr Tyr  Gly Asn Phe Asn Asn  Leu Arg Phe 
    2525                 2530                 2535             


Trp Tyr  Asn Leu Glu Ile His  Ser Thr Pro Gly Pro  Pro Ile Glu 
    2540                 2545                 2550             


Ile Met  Glu Met Thr Cys Ile  Ala Leu Asp Ser Thr  Cys Ile Glu 
    2555                 2560                 2565             


Ile Pro  Leu Ser Asn Pro Lys  Asp Arg Gly Leu His  Leu Glu Val 
    2570                 2575                 2580             


Gln Leu  Thr Ser Ala Ala Leu  Asn Gly Asp Asn Glu  Ile Ile Leu 
    2585                 2590                 2595             


Ser Pro  Leu Gln Cys Thr Lys  Tyr Ile Val Trp Tyr  Ser Pro Ala 
    2600                 2605                 2610             


Thr Thr  Gly Tyr Ser Asp Glu  Ser Ile Ile Phe Gln  Pro Glu Met 
    2615                 2620                 2625             


Ala Glu  Glu Phe Trp Tyr Leu  Leu Lys Leu Thr Ile  Glu Leu Pro 
    2630                 2635                 2640             


Lys Pro  Thr Thr Met Pro Glu  Ile Gln Cys Asp Leu  Gly Lys His 
    2645                 2650                 2655             


Val Thr  Gln Ile Ile Pro Leu  Val Asn Cys Thr His  Glu Thr Leu 
    2660                 2665                 2670             


Lys Leu  Gln Val Thr Asn Ser  Asn Pro Glu Asn Phe  Val Leu Asp 
    2675                 2680                 2685             


Ile Asn  Arg Lys Ser Gln Leu  Ile Ile Ser Pro His  Ser Thr Thr 
    2690                 2695                 2700             


Glu Leu  Pro Val Leu Phe Tyr  Pro Ser Ala Leu Gly  Arg Ala Asp 
    2705                 2710                 2715             


His Gln  Ala Cys Ile Asn Phe  Tyr Cys Thr Gln Phe  Thr Glu Trp 
    2720                 2725                 2730             


Lys Phe  Tyr Leu Ser Gly Val  Gly Leu Phe Pro Gln  Pro Leu Asp 
    2735                 2740                 2745             


Thr Glu  Arg Ile Thr Thr Arg  Ile Gly Leu Gln Ser  Thr Ile Val 
    2750                 2755                 2760             


Ile Pro  Phe Lys Asn Pro Thr  Met Glu Asp Val Leu  Ile Asp Ile 
    2765                 2770                 2775             


Ile Leu  Thr Ser Val Glu His  Pro Arg Asn Leu Val  Met Asp His 
    2780                 2785                 2790             


Cys Trp  Asp Ser Phe Ile Tyr  Glu Ser Ser Ala Phe  Arg Phe Ser 
    2795                 2800                 2805             


Ser Pro  Ser Glu Ile Gln Gly  Ile Ala Leu Pro Pro  Lys Gly Asn 
    2810                 2815                 2820             


Ile Asp  Ile Ser Leu Leu Phe  Ile Pro Gln Ile Met  Lys Leu His 
    2825                 2830                 2835             


Lys Thr  Met Val Ile Ile Glu  Met Thr Lys Ala Asn  Gly Lys Tyr 
    2840                 2845                 2850             


Trp Pro  Ile Asp Asn Phe Asp  Glu Leu Asp Ile Lys  Phe Lys Ser 
    2855                 2860                 2865             


Ile Val  Gly Ile Asp Ser Glu  Glu Ile Gln Ala Ile  His Trp Ile 
    2870                 2875                 2880             


Tyr Pro  Ile Val Gly Leu Pro  Gln Ala Pro Pro Pro  Lys Ser Pro 
    2885                 2890                 2895             


Pro Val  Val Ile Gln Cys Gln  Ser Arg Lys Arg Ala  Glu Glu Lys 
    2900                 2905                 2910             


Val Glu  Ile Ile Leu Asn Ala  Gly Phe Phe Gly Phe  Ser Leu Thr 
    2915                 2920                 2925             


Pro Asp  Leu Thr Glu Val Leu  Val Ile Pro Lys Arg  Asn Ser His 
    2930                 2935                 2940             


Asn Phe  Cys Glu Asp Pro Asn  Glu Ile Pro Lys Ile  His Glu Phe 
    2945                 2950                 2955             


Glu Tyr  Glu Ile Gln Phe Glu  Ser Glu Ala Met Lys  Ser Lys Leu 
    2960                 2965                 2970             


Glu Ser  Cys Val Ala Leu Tyr  Met Ile Glu Lys Ser  Tyr Asp Ile 
    2975                 2980                 2985             


Met Ala  Lys Arg Ile Thr Phe  Ile Phe Asn Leu Val  Phe Thr Pro 
    2990                 2995                 3000             


Lys Lys  Pro Leu Arg Ser His  Ile Thr Leu Lys Ile  Glu Cys Val 
    3005                 3010                 3015             


Thr Glu  Gly Ile Trp Lys Phe  Pro Ile Met Leu Ile  Ala Thr Glu 
    3020                 3025                 3030             


Pro Asp  Thr Asp Ala Val Ile  Asp Ile Glu Gly Val  Gly Leu Phe 
    3035                 3040                 3045             


Lys Glu  Ser Val Phe Glu Leu  Arg Leu Lys Ser Gln  Thr Arg Asn 
    3050                 3055                 3060             


Pro Glu  Pro Phe Thr Ala His  Phe Leu Pro Gly Ser  Asp Leu Glu 
    3065                 3070                 3075             


Phe Phe  Val Lys Pro Gln Ala  Gly Glu Leu Leu Pro  Phe Asn Thr 
    3080                 3085                 3090             


Asn Gly  Thr Leu Ile Thr Val  Gly Phe Lys Pro Lys  Met Tyr Cys 
    3095                 3100                 3105             


Arg Lys  Tyr Lys Ala Thr Leu  Val Ile Gln Thr Glu  Glu Met Tyr 
    3110                 3115                 3120             


Trp Lys  Tyr Glu Ile Asn Gly  Leu Thr Pro Thr Thr  Val Pro Pro 
    3125                 3130                 3135             


Lys Asn  Ala Lys Ala Lys Ile  Asp Ala Thr His Lys  Thr His Asp 
    3140                 3145                 3150             


Asn Met  Pro Val Arg Pro His  Asn Phe Val Arg Glu  Asn Thr Lys 
    3155                 3160                 3165             


Leu Ile  Arg Thr Gly Val Ser  Ser Thr Ile Lys Gly  Ala Pro Leu 
    3170                 3175                 3180             


Val Lys  Asn Gln 
    3185         


<210>  6384
<211>  1154
<212>  PRT
<213>  Homo sapiens

<400>  6384

Met Gly Leu Leu Leu Met Ile Leu Ala Ser Ala Val Leu Gly Ser Phe 
1               5                   10                  15      


Leu Thr Leu Leu Ala Gln Phe Phe Leu Leu Tyr Arg Arg Gln Pro Glu 
            20                  25                  30          


Pro Pro Ala Asp Glu Ala Ala Arg Ala Gly Glu Gly Phe Arg Tyr Ile 
        35                  40                  45              


Lys Pro Val Pro Gly Leu Leu Leu Arg Glu Tyr Leu Tyr Gly Gly Gly 
    50                  55                  60                  


Arg Asp Glu Glu Pro Ser Gly Ala Ala Pro Glu Gly Gly Ala Thr Pro 
65                  70                  75                  80  


Thr Ala Ala Pro Glu Thr Pro Ala Pro Pro Thr Arg Glu Thr Cys Tyr 
                85                  90                  95      


Phe Leu Asn Ala Thr Ile Leu Phe Leu Phe Arg Glu Leu Arg Asp Thr 
            100                 105                 110         


Ala Leu Thr Arg Arg Trp Val Thr Lys Lys Ile Lys Val Glu Phe Glu 
        115                 120                 125             


Glu Leu Leu Gln Thr Lys Thr Ala Gly Arg Leu Leu Glu Gly Leu Ser 
    130                 135                 140                 


Leu Arg Asp Val Phe Leu Gly Glu Thr Val Pro Phe Ile Lys Thr Ile 
145                 150                 155                 160 


Arg Leu Val Arg Pro Val Val Pro Ser Ala Thr Gly Glu Pro Asp Gly 
                165                 170                 175     


Pro Glu Gly Glu Ala Leu Pro Ala Ala Cys Pro Glu Glu Leu Ala Phe 
            180                 185                 190         


Glu Ala Glu Val Glu Tyr Asn Gly Gly Phe His Leu Ala Ile Asp Val 
        195                 200                 205             


Asp Leu Val Phe Gly Lys Ser Ala Tyr Leu Phe Val Lys Leu Ser Arg 
    210                 215                 220                 


Val Val Gly Arg Leu Arg Leu Val Phe Thr Arg Val Pro Phe Thr His 
225                 230                 235                 240 


Trp Phe Phe Ser Phe Val Glu Asp Pro Leu Ile Asp Phe Glu Val Arg 
                245                 250                 255     


Ser Gln Phe Glu Gly Arg Pro Met Pro Gln Leu Thr Ser Ile Ile Val 
            260                 265                 270         


Asn Gln Leu Lys Lys Ile Ile Lys Arg Lys His Thr Leu Pro Asn Tyr 
        275                 280                 285             


Lys Ile Arg Phe Lys Pro Phe Phe Pro Tyr Gln Thr Leu Gln Gly Phe 
    290                 295                 300                 


Glu Glu Asp Glu Glu His Ile His Ile Gln Gln Trp Ala Leu Thr Glu 
305                 310                 315                 320 


Gly Arg Leu Lys Val Thr Leu Leu Glu Cys Ser Arg Leu Leu Ile Phe 
                325                 330                 335     


Gly Ser Tyr Asp Arg Glu Ala Asn Val His Cys Thr Leu Glu Leu Ser 
            340                 345                 350         


Ser Ser Val Trp Glu Glu Lys Gln Arg Ser Ser Ile Lys Thr Val Glu 
        355                 360                 365             


Leu Ile Lys Gly Asn Leu Gln Ser Val Gly Leu Thr Leu Arg Leu Val 
    370                 375                 380                 


Gln Ser Thr Asp Gly Tyr Ala Gly His Val Ile Ile Glu Thr Val Ala 
385                 390                 395                 400 


Pro Asn Ser Pro Ala Ala Ile Ala Asp Leu Gln Arg Gly Asp Arg Leu 
                405                 410                 415     


Ile Ala Ile Gly Gly Val Lys Ile Thr Ser Thr Leu Gln Val Leu Lys 
            420                 425                 430         


Leu Ile Lys Gln Ala Gly Asp Arg Val Leu Val Tyr Tyr Glu Arg Pro 
        435                 440                 445             


Val Gly Gln Ser Asn Gln Gly Ala Val Leu Gln Asp Asn Phe Gly Gln 
    450                 455                 460                 


Leu Glu Glu Asn Phe Leu Ser Ser Ser Cys Gln Ser Gly Tyr Glu Glu 
465                 470                 475                 480 


Glu Ala Ala Gly Leu Thr Val Asp Thr Glu Ser Arg Glu Leu Asp Ser 
                485                 490                 495     


Glu Phe Glu Asp Leu Ala Ser Asp Val Arg Ala Gln Asn Glu Phe Lys 
            500                 505                 510         


Asp Glu Ala Gln Ser Leu Ser His Ser Pro Lys Arg Val Pro Thr Thr 
        515                 520                 525             


Leu Ser Ile Lys Pro Leu Gly Ala Ile Ser Pro Val Leu Asn Arg Lys 
    530                 535                 540                 


Leu Ala Val Gly Ser His Pro Leu Pro Pro Lys Ile Gln Ser Lys Asp 
545                 550                 555                 560 


Gly Asn Lys Pro Pro Pro Leu Lys Thr Ser Glu Ile Thr Asp Pro Ala 
                565                 570                 575     


Gln Val Ser Lys Pro Thr Gln Gly Ser Ala Phe Lys Pro Pro Val Pro 
            580                 585                 590         


Pro Arg Pro Gln Ala Lys Val Pro Leu Pro Ser Ala Asp Ala Pro Asn 
        595                 600                 605             


Gln Ala Glu Pro Asp Val Leu Val Glu Lys Pro Glu Lys Val Val Pro 
    610                 615                 620                 


Pro Pro Leu Val Asp Lys Ser Ala Glu Lys Gln Ala Lys Asn Val Asp 
625                 630                 635                 640 


Ala Ile Asp Asp Ala Ala Ala Pro Lys Gln Phe Leu Ala Lys Gln Glu 
                645                 650                 655     


Val Ala Lys Asp Val Thr Ser Glu Thr Ser Cys Pro Thr Lys Asp Ser 
            660                 665                 670         


Ser Asp Asp Arg Gln Thr Trp Glu Ser Ser Glu Ile Leu Tyr Arg Asn 
        675                 680                 685             


Lys Leu Gly Lys Trp Thr Arg Thr Arg Ala Ser Cys Leu Phe Asp Ile 
    690                 695                 700                 


Glu Ala Cys His Arg Tyr Leu Asn Ile Ala Leu Trp Cys Arg Asp Pro 
705                 710                 715                 720 


Phe Lys Leu Gly Gly Leu Ile Cys Leu Gly His Val Ser Leu Lys Leu 
                725                 730                 735     


Glu Asp Val Ala Leu Gly Cys Leu Ala Thr Ser Asn Thr Glu Tyr Leu 
            740                 745                 750         


Ser Lys Leu Arg Leu Glu Ala Pro Ser Pro Lys Ala Ile Val Thr Arg 
        755                 760                 765             


Thr Ala Leu Arg Asn Leu Ser Met Gln Lys Gly Phe Asn Asp Lys Phe 
    770                 775                 780                 


Cys Tyr Gly Asp Ile Thr Ile His Phe Lys Tyr Leu Lys Glu Gly Glu 
785                 790                 795                 800 


Ser Asp His His Val Val Thr Asn Val Glu Lys Glu Lys Glu Pro His 
                805                 810                 815     


Leu Val Glu Glu Val Ser Val Leu Pro Lys Glu Glu Gln Phe Val Gly 
            820                 825                 830         


Gln Met Gly Leu Thr Glu Asn Lys His Ser Phe Gln Asp Thr Gln Phe 
        835                 840                 845             


Gln Asn Pro Thr Trp Cys Asp Tyr Cys Lys Lys Lys Val Trp Thr Lys 
    850                 855                 860                 


Ala Ala Ser Gln Cys Met Phe Cys Ala Tyr Val Cys His Lys Lys Cys 
865                 870                 875                 880 


Gln Glu Lys Cys Leu Ala Glu Thr Ser Val Cys Gly Ala Thr Asp Arg 
                885                 890                 895     


Arg Ile Asp Arg Thr Leu Lys Asn Leu Arg Leu Glu Gly Gln Glu Thr 
            900                 905                 910         


Leu Leu Gly Leu Pro Pro Arg Val Asp Ala Glu Ala Ser Lys Ser Val 
        915                 920                 925             


Asn Lys Thr Thr Gly Leu Thr Arg His Ile Ile Asn Thr Ser Ser Arg 
    930                 935                 940                 


Leu Leu Asn Leu Arg Gln Val Ser Lys Thr Arg Leu Ser Glu Pro Gly 
945                 950                 955                 960 


Thr Asp Leu Val Glu Pro Ser Pro Lys His Thr Pro Asn Thr Ser Asp 
                965                 970                 975     


Asn Glu Gly Ser Asp Thr Glu Val Cys Gly Pro Asn Ser Pro Ser Lys 
            980                 985                 990         


Arg Gly Asn Ser Thr Gly Ile Lys  Leu Val Arg Lys Glu  Gly Gly Leu 
        995                 1000                 1005             


Asp Asp  Ser Val Phe Ile Ala  Val Lys Glu Ile Gly  Arg Asp Leu 
    1010                 1015                 1020             


Tyr Arg  Gly Leu Pro Thr Glu  Glu Arg Ile Gln Lys  Leu Glu Phe 
    1025                 1030                 1035             


Met Leu  Asp Lys Leu Gln Asn  Glu Ile Asp Gln Glu  Leu Glu His 
    1040                 1045                 1050             


Asn Asn  Ser Leu Val Arg Glu  Glu Lys Glu Thr Thr  Asp Thr Arg 
    1055                 1060                 1065             


Lys Lys  Ser Leu Leu Ser Ala  Ala Leu Ala Lys Ser  Gly Glu Arg 
    1070                 1075                 1080             


Leu Gln  Ala Leu Thr Leu Leu  Met Ile His Tyr Arg  Ala Gly Ile 
    1085                 1090                 1095             


Glu Asp  Ile Glu Thr Leu Glu  Ser Leu Ser Leu Asp  Gln His Ser 
    1100                 1105                 1110             


Lys Lys  Ile Ser Lys Tyr Thr  Asp Asp Thr Glu Glu  Asp Leu Asp 
    1115                 1120                 1125             


Asn Glu  Ile Ser Gln Leu Ile  Asp Ser Gln Pro Phe  Ser Ser Ile 
    1130                 1135                 1140             


Ser Asp  Asp Leu Phe Gly Pro  Ser Glu Ser Val 
    1145                 1150                 


<210>  6385
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  6385

Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala 
1               5                   10                  15      


Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn 
            20                  25                  30          


Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser 
        35                  40                  45              


Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln 
    50                  55                  60                  


Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser 
65                  70                  75                  80  


Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln 
                85                  90                  95      


Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr 
            100                 105                 110         


Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu 
        115                 120                 125             


Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Leu Leu Gly 
    130                 135                 140                 


Ala Met Ala Ala Thr Leu Val Val Ile Cys Thr Ala Val Ile Val Val 
145                 150                 155                 160 


Val Ala Leu Thr Arg Lys Lys Lys Ala Leu Arg Ile His Ser Val Glu 
                165                 170                 175     


Gly Asp Leu Arg Arg Lys Ser Ala Gly Gln Glu Glu Trp Ser Pro Ser 
            180                 185                 190         


Ala Pro Ser Pro Pro Gly Ser Cys Val Gln Ala Glu Ala Ala Pro Ala 
        195                 200                 205             


Gly Leu Cys Gly Glu Gln Arg Gly Glu Asp Cys Ala Glu Leu His Asp 
    210                 215                 220                 


Tyr Phe Asn Val Leu Ser Tyr Arg Ser Leu Gly Asn Cys Ser Phe Phe 
225                 230                 235                 240 


Thr Glu Thr Gly 
                


<210>  6386
<211>  990
<212>  PRT
<213>  Homo sapiens

<400>  6386

Met Gly Pro Pro Ser Ser Ser Gly Phe Tyr Val Ser Arg Ala Val Ala 
1               5                   10                  15      


Leu Leu Leu Ala Gly Leu Val Ala Ala Leu Leu Leu Ala Leu Ala Val 
            20                  25                  30          


Leu Ala Ala Leu Tyr Gly His Cys Glu Arg Val Pro Pro Ser Glu Leu 
        35                  40                  45              


Pro Gly Leu Arg Asp Leu Glu Ala Glu Ser Ser Pro Pro Leu Arg Gln 
    50                  55                  60                  


Lys Pro Thr Pro Thr Pro Lys Pro Ser Ser Ala Arg Glu Leu Ala Val 
65                  70                  75                  80  


Thr Thr Thr Pro Ser Asn Trp Arg Pro Pro Gly Pro Trp Asp Gln Leu 
                85                  90                  95      


Arg Leu Pro Pro Trp Leu Val Pro Leu His Tyr Asp Leu Glu Leu Trp 
            100                 105                 110         


Pro Gln Leu Arg Pro Asp Glu Leu Pro Ala Gly Ser Leu Pro Phe Thr 
        115                 120                 125             


Gly Arg Val Asn Ile Thr Val Arg Cys Thr Val Ala Thr Ser Arg Leu 
    130                 135                 140                 


Leu Leu His Ser Leu Phe Gln Asp Cys Glu Arg Ala Glu Val Arg Gly 
145                 150                 155                 160 


Pro Leu Ser Pro Gly Thr Gly Asn Ala Thr Val Gly Arg Val Pro Val 
                165                 170                 175     


Asp Asp Val Trp Phe Ala Leu Asp Thr Glu Tyr Met Val Leu Glu Leu 
            180                 185                 190         


Ser Glu Pro Leu Lys Pro Gly Ser Ser Tyr Glu Leu Gln Leu Ser Phe 
        195                 200                 205             


Ser Gly Leu Val Lys Glu Asp Leu Arg Glu Gly Leu Phe Leu Asn Val 
    210                 215                 220                 


Tyr Thr Asp Gln Gly Glu Arg Arg Ala Leu Leu Ala Ser Gln Leu Glu 
225                 230                 235                 240 


Pro Thr Phe Ala Arg Tyr Val Phe Pro Cys Phe Asp Glu Pro Ala Leu 
                245                 250                 255     


Lys Ala Thr Phe Asn Ile Thr Met Ile His His Pro Ser Tyr Val Ala 
            260                 265                 270         


Leu Ser Asn Met Pro Lys Leu Gly Gln Ser Glu Lys Glu Asp Val Asn 
        275                 280                 285             


Gly Ser Lys Trp Thr Val Thr Thr Phe Ser Thr Thr Pro His Met Pro 
    290                 295                 300                 


Thr Tyr Leu Val Ala Phe Val Ile Cys Asp Tyr Asp His Val Asn Arg 
305                 310                 315                 320 


Thr Glu Arg Gly Lys Glu Ile Arg Ile Trp Ala Arg Lys Asp Ala Ile 
                325                 330                 335     


Ala Asn Gly Ser Ala Asp Phe Ala Leu Asn Ile Thr Gly Pro Ile Phe 
            340                 345                 350         


Ser Phe Leu Glu Asp Leu Phe Asn Ile Ser Tyr Ser Leu Pro Lys Thr 
        355                 360                 365             


Asp Ile Ile Ala Leu Pro Ser Phe Asp Asn His Ala Met Glu Asn Trp 
    370                 375                 380                 


Gly Leu Met Ile Phe Asp Glu Ser Gly Leu Leu Leu Glu Pro Lys Asp 
385                 390                 395                 400 


Gln Leu Thr Glu Lys Lys Thr Leu Ile Ser Tyr Val Val Ser His Glu 
                405                 410                 415     


Ile Gly His Gln Trp Phe Gly Asn Leu Val Thr Met Asn Trp Trp Asn 
            420                 425                 430         


Asn Ile Trp Leu Asn Glu Gly Phe Ala Ser Tyr Phe Glu Phe Glu Val 
        435                 440                 445             


Ile Asn Tyr Phe Asn Pro Lys Leu Pro Arg Asn Glu Ile Phe Phe Ser 
    450                 455                 460                 


Asn Ile Leu His Asn Ile Leu Arg Glu Asp His Ala Leu Val Thr Arg 
465                 470                 475                 480 


Ala Val Ala Met Lys Val Glu Asn Phe Lys Thr Ser Glu Ile Gln Glu 
                485                 490                 495     


Leu Phe Asp Ile Phe Thr Tyr Ser Lys Gly Ala Ser Met Ala Arg Met 
            500                 505                 510         


Leu Ser Cys Phe Leu Asn Glu His Leu Phe Val Ser Ala Leu Lys Ser 
        515                 520                 525             


Tyr Leu Lys Thr Phe Ser Tyr Ser Asn Ala Glu Gln Asp Asp Leu Trp 
    530                 535                 540                 


Arg His Phe Gln Met Ala Ile Asp Asp Gln Ser Thr Val Ile Leu Pro 
545                 550                 555                 560 


Ala Thr Ile Lys Asn Ile Met Asp Ser Trp Thr His Gln Ser Gly Phe 
                565                 570                 575     


Pro Val Ile Thr Leu Asn Val Ser Thr Gly Val Met Lys Gln Glu Pro 
            580                 585                 590         


Phe Tyr Leu Glu Asn Ile Lys Asn Arg Thr Leu Leu Thr Ser Asn Asp 
        595                 600                 605             


Thr Trp Ile Val Pro Ile Leu Trp Ile Lys Asn Gly Thr Thr Gln Pro 
    610                 615                 620                 


Leu Val Trp Leu Asp Gln Ser Ser Lys Val Phe Pro Glu Met Gln Val 
625                 630                 635                 640 


Ser Asp Ser Asp His Asp Trp Val Ile Leu Asn Leu Asn Met Thr Gly 
                645                 650                 655     


Tyr Tyr Arg Val Asn Tyr Asp Lys Leu Gly Trp Lys Lys Leu Asn Gln 
            660                 665                 670         


Gln Leu Glu Lys Asp Pro Lys Ala Ile Pro Val Ile His Arg Leu Gln 
        675                 680                 685             


Leu Ile Asp Asp Ala Phe Ser Leu Ser Lys Asn Asn Tyr Ile Glu Ile 
    690                 695                 700                 


Glu Thr Ala Leu Glu Leu Thr Lys Tyr Leu Ala Glu Glu Asp Glu Ile 
705                 710                 715                 720 


Ile Val Trp His Thr Val Leu Val Asn Leu Val Thr Arg Asp Leu Val 
                725                 730                 735     


Ser Glu Val Asn Ile Tyr Asp Ile Tyr Ser Leu Leu Lys Arg Tyr Leu 
            740                 745                 750         


Leu Lys Arg Leu Asn Leu Ile Trp Asn Ile Tyr Ser Thr Ile Ile Arg 
        755                 760                 765             


Glu Asn Val Leu Ala Leu Gln Asp Asp Tyr Leu Ala Leu Ile Ser Leu 
    770                 775                 780                 


Glu Lys Leu Phe Val Thr Ala Cys Trp Leu Gly Leu Glu Asp Cys Leu 
785                 790                 795                 800 


Gln Leu Ser Lys Glu Leu Phe Ala Lys Trp Val Asp His Pro Glu Asn 
                805                 810                 815     


Glu Ile Pro Tyr Pro Ile Lys Asp Val Val Leu Cys Tyr Gly Ile Ala 
            820                 825                 830         


Leu Gly Ser Asp Lys Glu Trp Asp Ile Leu Leu Asn Thr Tyr Thr Asn 
        835                 840                 845             


Thr Thr Asn Lys Glu Glu Lys Ile Gln Leu Ala Tyr Ala Met Ser Cys 
    850                 855                 860                 


Ser Lys Asp Pro Trp Ile Leu Asn Arg Tyr Met Glu Tyr Ala Ile Ser 
865                 870                 875                 880 


Thr Ser Pro Phe Thr Ser Asn Glu Thr Asn Ile Ile Glu Val Val Ala 
                885                 890                 895     


Ser Ser Glu Val Gly Arg Tyr Val Ala Lys Asp Phe Leu Val Asn Asn 
            900                 905                 910         


Trp Gln Ala Val Ser Lys Arg Tyr Gly Thr Gln Ser Leu Ile Asn Leu 
        915                 920                 925             


Ile Tyr Thr Ile Gly Arg Thr Val Thr Thr Asp Leu Gln Ile Val Glu 
    930                 935                 940                 


Leu Gln Gln Phe Phe Ser Asn Met Leu Glu Glu His Gln Arg Ile Arg 
945                 950                 955                 960 


Val His Ala Asn Leu Gln Thr Ile Lys Asn Glu Asn Leu Lys Asn Lys 
                965                 970                 975     


Lys Leu Ser Ala Arg Ile Ala Ala Trp Leu Arg Arg Asn Thr 
            980                 985                 990 


<210>  6387
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  6387

Met Asp Ala Gly Lys Ala Gly Gln Thr Leu Lys Thr His Cys Ser Ala 
1               5                   10                  15      


Gln Arg Pro Asp Val Cys Arg Trp Leu Ser Pro Phe Ile Leu Ser Cys 
            20                  25                  30          


Cys Val Tyr Phe Cys Leu Trp Ile Pro Glu Asp Gln Leu Ser Trp Phe 
        35                  40                  45              


Ala Ala Leu Val Lys Cys Leu Pro Val Leu Cys Leu Ala Gly Phe Leu 
    50                  55                  60                  


Trp Val Met Ser Pro Ser Gly Gly Tyr Thr Gln Leu Leu Gln Gly Ala 
65                  70                  75                  80  


Leu Val Cys Ser Ala Val Gly Asp Ala Cys Leu Ile Trp Pro Ala Ala 
                85                  90                  95      


Phe Val Pro Gly Met Ala Ala Phe Ala Thr Ala His Leu Leu Tyr Val 
            100                 105                 110         


Trp Ala Phe Gly Phe Ser Pro Leu Gln Pro Gly Leu Leu Leu Leu Ile 
        115                 120                 125             


Ile Leu Ala Pro Gly Pro Tyr Leu Ser Leu Val Leu Gln His Leu Glu 
    130                 135                 140                 


Pro Asp Met Val Leu Pro Val Ala Ala Tyr Gly Leu Ile Leu Met Ala 
145                 150                 155                 160 


Met Leu Trp Arg Gly Leu Ala Gln Gly Gly Ser Ala Gly Trp Gly Ala 
                165                 170                 175     


Leu Leu Phe Thr Leu Ser Asp Gly Val Leu Ala Trp Asp Thr Phe Ala 
            180                 185                 190         


Gln Pro Leu Pro His Ala His Leu Val Ile Met Thr Thr Tyr Tyr Ala 
        195                 200                 205             


Ala Gln Leu Leu Ile Thr Leu Ser Ala Leu Arg Ser Pro Val Pro Lys 
    210                 215                 220                 


Thr Asp 
225     


<210>  6388
<211>  832
<212>  PRT
<213>  Homo sapiens

<400>  6388

Met Ser Ala Arg Glu Val Ala Val Leu Leu Leu Trp Leu Ser Cys Tyr 
1               5                   10                  15      


Gly Ser Ala Leu Trp Arg Tyr Ser Thr Asn Ser Pro Asn Tyr Arg Ile 
            20                  25                  30          


Phe Ser Thr Arg Ser Thr Ile Lys Leu Glu Tyr Glu Gly Thr Leu Phe 
        35                  40                  45              


Thr Glu Trp Ser Val Pro Glu Thr Cys Phe Val Leu Asn Lys Ser Ser 
    50                  55                  60                  


Pro Thr Thr Glu Leu Arg Cys Ser Ser Pro Gly Val His Ala Ile Lys 
65                  70                  75                  80  


Pro Ile Val Thr Gly Pro Asp Glu Glu Glu Arg Tyr Leu Phe Val Glu 
                85                  90                  95      


Ser Ser His Thr Cys Phe Leu Trp Tyr Tyr Arg Val Arg His Phe Phe 
            100                 105                 110         


Asn Asn Phe Thr Gln Leu Ile Thr Val Trp Ala Tyr Asp Pro Glu Ser 
        115                 120                 125             


Ala Asp Pro Asp Glu Leu Leu Gly Asn Ala Glu Glu Pro Ser Ile Asn 
    130                 135                 140                 


Ser Ile Val Leu Ser Thr Gln Met Ala Thr Leu Gly Gln Lys Pro Val 
145                 150                 155                 160 


Ile His Thr Val Leu Lys Arg Lys Val Tyr Ser Ser Asn Glu Lys Met 
                165                 170                 175     


Arg Arg Gly Thr Trp Arg Ile Val Val Pro Met Thr Lys Asp Asp Ala 
            180                 185                 190         


Leu Lys Glu Ile Arg Gly Asn Gln Val Thr Phe Gln Asp Cys Phe Ile 
        195                 200                 205             


Ala Asp Phe Leu Ile Leu Leu Thr Phe Pro Leu Leu Thr Ile Pro Glu 
    210                 215                 220                 


Ile Pro Gly Tyr Leu Pro Ile Ser Ser Pro Arg Gly Ser Gln Leu Met 
225                 230                 235                 240 


Ala Ser Trp Asp Ala Cys Val Val Ala Ser Ala Val Leu Val Thr Asp 
                245                 250                 255     


Met Glu Thr Phe His Thr Thr Asp Ser Phe Lys Ser Trp Thr Arg Ile 
            260                 265                 270         


Arg Val Pro Pro Asp Ile Leu Ser Asp Asp Glu Arg Arg Ser Val Ala 
        275                 280                 285             


His Val Ile Leu Ser Arg Asp Gly Ile Val Phe Leu Ile Asn Gly Val 
    290                 295                 300                 


Leu Tyr Ile Lys Ser Phe Arg Gly Phe Ile Arg Leu Gly Gly Ile Val 
305                 310                 315                 320 


Asn Leu Pro Asp Gly Gly Ile Thr Gly Ile Ser Ser Arg Lys Trp Cys 
                325                 330                 335     


Trp Val Asn Tyr Leu Leu Lys Ala Lys Gly Arg Arg Ser Thr Phe Ala 
            340                 345                 350         


Val Trp Thr Glu Asn Glu Ile Tyr Leu Gly Ser Ile Leu Leu Lys Phe 
        355                 360                 365             


Ala Arg Leu Val Thr Thr Thr Glu Leu Lys Asn Ile Leu Ser Leu Ser 
    370                 375                 380                 


Val Thr Ala Thr Leu Thr Ile Asp Arg Val Glu Tyr Thr Gly His Pro 
385                 390                 395                 400 


Leu Glu Ile Ala Val Phe Leu Asn Tyr Cys Thr Val Cys Asn Val Thr 
                405                 410                 415     


Lys Lys Ile Phe Leu Val Ile Tyr Asn Glu Asp Thr Lys Gln Trp Val 
            420                 425                 430         


Ser Gln Asp Phe Thr Leu Asp Ala Pro Ile Asp Ser Val Thr Met Pro 
        435                 440                 445             


His Phe Thr Phe Ser Ala Leu Pro Gly Leu Leu Leu Trp Asn Lys His 
    450                 455                 460                 


Ser Ile Tyr Tyr Cys Tyr His Asn Phe Thr Phe Thr Gly Ile Leu Gln 
465                 470                 475                 480 


Thr Pro Ala Gly His Gly Asn Leu Ser Met Leu Ser Asn Asp Ser Ile 
                485                 490                 495     


Ile His Glu Val Phe Ile Asp Tyr Tyr Gly Asp Ile Leu Val Lys Met 
            500                 505                 510         


Glu Asn Asn Val Ile Phe Tyr Ser Lys Ile Asn Thr Arg Asp Ala Val 
        515                 520                 525             


Lys Leu His Leu Trp Thr Asn Tyr Thr Thr Arg Ala Phe Ile Phe Leu 
    530                 535                 540                 


Ser Thr Ser Gly Gln Thr Tyr Phe Leu Tyr Ala Leu Asp Asp Gly Thr 
545                 550                 555                 560 


Ile Gln Ile Gln Asp Tyr Pro Leu His Leu Glu Ala Gln Ser Ile Ala 
                565                 570                 575     


Phe Thr Thr Lys Asp Lys Cys Pro Tyr Met Ala Phe His Asn Asn Val 
            580                 585                 590         


Ala His Val Phe Tyr Phe Leu Asp Lys Gly Glu Ala Leu Thr Val Trp 
        595                 600                 605             


Thr Gln Ile Val Tyr Pro Glu Asn Thr Gly Leu Tyr Val Ile Val Glu 
    610                 615                 620                 


Ser Tyr Gly Pro Lys Ile Leu Gln Glu Ser His Glu Ile Ser Phe Glu 
625                 630                 635                 640 


Ala Ala Phe Gly Tyr Cys Thr Lys Thr Leu Thr Leu Thr Phe Tyr Gln 
                645                 650                 655     


Asn Val Asp Tyr Glu Arg Ile Ser Asp Tyr Phe Glu Thr Gln Asp Lys 
            660                 665                 670         


His Thr Gly Leu Val Leu Val Gln Phe Arg Pro Ser Glu Tyr Ser Lys 
        675                 680                 685             


Ala Cys Pro Ile Ala Gln Lys Val Phe Gln Ile Ala Val Gly Cys Asp 
    690                 695                 700                 


Asp Lys Lys Phe Ile Ala Ile Lys Gly Phe Ser Lys Lys Gly Cys His 
705                 710                 715                 720 


His His Asp Phe Ser Tyr Val Ile Glu Lys Ser Tyr Leu Arg His Gln 
                725                 730                 735     


Pro Ser Lys Asn Leu Arg Val Arg Tyr Ile Trp Gly Glu Tyr Gly Cys 
            740                 745                 750         


Pro Leu Arg Leu Asp Phe Thr Glu Lys Phe Gln Pro Val Val Gln Leu 
        755                 760                 765             


Phe Asp Asp Asn Gly Tyr Val Lys Asp Val Glu Ala Asn Phe Ile Val 
    770                 775                 780                 


Trp Glu Ile His Gly Arg Asp Asp Tyr Ser Phe Asn Asn Thr Met Ala 
785                 790                 795                 800 


Gln Ser Gly Cys Leu His Glu Ala Gln Thr Trp Lys Ser Met Ile Glu 
                805                 810                 815     


Leu Asn Lys His Leu Pro Leu Glu Glu Val Trp Gly Pro Glu Phe Leu 
            820                 825                 830         


<210>  6389
<211>  758
<212>  PRT
<213>  Homo sapiens

<400>  6389

Met Arg Lys Gln Gly Val Ser Ser Lys Arg Leu Gln Ser Ser Gly Arg 
1               5                   10                  15      


Ser Gln Ser Lys Gly Arg Arg Gly Ala Ser Leu Ala Arg Glu Pro Glu 
            20                  25                  30          


Val Glu Glu Glu Met Glu Lys Ser Ala Leu Gly Gly Gly Lys Leu Pro 
        35                  40                  45              


Arg Gly Ser Trp Arg Ser Ser Pro Gly Arg Ile Gln Ser Leu Lys Glu 
    50                  55                  60                  


Arg Lys Gly Leu Glu Leu Glu Val Val Ala Lys Thr Phe Leu Leu Gly 
65                  70                  75                  80  


Pro Phe Gln Phe Val Arg Asn Ser Leu Ala Gln Leu Arg Glu Lys Val 
                85                  90                  95      


Gln Glu Leu Gln Ala Arg Arg Phe Ser Ser Arg Thr Thr Leu Gly Ile 
            100                 105                 110         


Ala Val Phe Val Ala Ile Leu His Trp Leu His Leu Val Thr Leu Phe 
        115                 120                 125             


Glu Asn Asp Arg His Phe Ser His Leu Ser Ser Leu Glu Arg Glu Met 
    130                 135                 140                 


Thr Phe Arg Thr Glu Met Gly Leu Tyr Tyr Ser Tyr Phe Lys Thr Ile 
145                 150                 155                 160 


Ile Glu Ala Pro Ser Phe Leu Glu Gly Leu Trp Met Ile Met Asn Asp 
                165                 170                 175     


Arg Leu Thr Glu Tyr Pro Leu Ile Ile Asn Ala Ile Lys Arg Phe His 
            180                 185                 190         


Leu Tyr Pro Glu Val Ile Ile Ala Ser Trp Tyr Cys Thr Phe Met Gly 
        195                 200                 205             


Ile Met Asn Leu Phe Gly Leu Glu Thr Lys Thr Cys Trp Asn Val Thr 
    210                 215                 220                 


Arg Ile Glu Pro Leu Asn Glu Val Gln Ser Cys Glu Gly Leu Gly Asp 
225                 230                 235                 240 


Pro Ala Cys Phe Tyr Val Gly Val Ile Phe Ile Leu Asn Gly Leu Met 
                245                 250                 255     


Met Gly Leu Phe Phe Met Tyr Gly Ala Tyr Leu Ser Gly Thr Gln Leu 
            260                 265                 270         


Gly Gly Leu Ile Thr Val Leu Cys Phe Phe Phe Asn His Gly Glu Ala 
        275                 280                 285             


Thr Arg Val Met Trp Thr Pro Pro Leu Arg Glu Ser Phe Ser Tyr Pro 
    290                 295                 300                 


Phe Leu Val Leu Gln Met Cys Ile Leu Thr Leu Ile Leu Arg Thr Ser 
305                 310                 315                 320 


Ser Asn Asp Arg Arg Pro Phe Ile Ala Leu Cys Leu Ser Asn Val Ala 
                325                 330                 335     


Phe Met Leu Pro Trp Gln Phe Ala Gln Phe Ile Leu Phe Thr Gln Ile 
            340                 345                 350         


Ala Ser Leu Phe Pro Met Tyr Val Val Gly Tyr Ile Glu Pro Ser Lys 
        355                 360                 365             


Phe Gln Lys Ile Ile Tyr Met Asn Met Ile Ser Val Thr Leu Ser Phe 
    370                 375                 380                 


Ile Leu Met Phe Gly Asn Ser Met Tyr Leu Ser Ser Tyr Tyr Ser Ser 
385                 390                 395                 400 


Ser Leu Leu Met Thr Trp Ala Ile Ile Leu Lys Arg Asn Glu Ile Gln 
                405                 410                 415     


Lys Leu Gly Val Ser Lys Leu Asn Phe Trp Leu Ile Gln Gly Ser Ala 
            420                 425                 430         


Trp Trp Cys Gly Thr Ile Ile Leu Lys Phe Leu Thr Ser Lys Ile Leu 
        435                 440                 445             


Gly Val Ser Asp His Ile Arg Leu Ser Asp Leu Ile Ala Ala Arg Ile 
    450                 455                 460                 


Leu Arg Tyr Thr Asp Phe Asp Thr Leu Ile Tyr Thr Cys Ala Pro Glu 
465                 470                 475                 480 


Phe Asp Phe Met Glu Lys Ala Thr Pro Leu Arg Tyr Thr Lys Thr Leu 
                485                 490                 495     


Leu Leu Pro Val Val Met Val Ile Thr Cys Phe Ile Phe Lys Lys Thr 
            500                 505                 510         


Val Arg Asp Ile Ser Tyr Val Leu Ala Thr Asn Ile Tyr Leu Arg Lys 
        515                 520                 525             


Gln Leu Leu Glu His Ser Glu Leu Ala Phe His Thr Leu Gln Leu Leu 
    530                 535                 540                 


Val Phe Thr Ala Leu Ala Ile Leu Ile Met Arg Leu Lys Met Phe Leu 
545                 550                 555                 560 


Thr Pro His Met Cys Val Met Ala Ser Leu Ile Cys Ser Arg Gln Leu 
                565                 570                 575     


Phe Gly Trp Leu Phe Arg Arg Val Arg Phe Glu Lys Val Ile Phe Gly 
            580                 585                 590         


Ile Leu Thr Val Met Ser Ile Gln Gly Tyr Ala Asn Leu Arg Asn Gln 
        595                 600                 605             


Trp Ser Ile Ile Gly Glu Phe Asn Asn Leu Pro Gln Glu Glu Leu Leu 
    610                 615                 620                 


Gln Trp Ile Lys Tyr Ser Thr Thr Ser Asp Ala Val Phe Ala Gly Ala 
625                 630                 635                 640 


Met Pro Thr Met Ala Ser Ile Lys Leu Ser Thr Leu His Pro Ile Val 
                645                 650                 655     


Asn His Pro His Tyr Glu Asp Ala Asp Leu Arg Ala Arg Thr Lys Ile 
            660                 665                 670         


Val Tyr Ser Thr Tyr Ser Arg Lys Ser Ala Lys Glu Val Arg Asp Lys 
        675                 680                 685             


Leu Leu Glu Leu His Val Asn Tyr Tyr Val Leu Glu Glu Ala Trp Cys 
    690                 695                 700                 


Val Val Arg Thr Lys Pro Gly Cys Ser Met Leu Glu Ile Trp Asp Val 
705                 710                 715                 720 


Glu Asp Pro Ser Asn Ala Ala Asn Pro Pro Leu Cys Ser Val Leu Leu 
                725                 730                 735     


Glu Asp Ala Arg Pro Tyr Phe Thr Thr Val Phe Gln Asn Ser Val Tyr 
            740                 745                 750         


Arg Val Leu Lys Val Asn 
        755             


<210>  6390
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  6390

Met Leu Cys Arg Leu Gly Gly Arg Trp Leu Arg Pro Leu Pro Ala Leu 
1               5                   10                  15      


Gln Leu Trp Ala Arg Asp Leu Pro Leu Ala Pro Val Pro Thr Ser Gly 
            20                  25                  30          


Ala Lys Arg Pro Thr Leu Pro Val Trp Ala Val Ala Pro Val Ser Ala 
        35                  40                  45              


Val His Ala Asn Gly Trp Tyr Glu Ala Leu Ala Ala Ser Ser Pro Val 
    50                  55                  60                  


Arg Val Ala Glu Glu Val Leu Leu Gly Val His Ala Ala Thr Gly Leu 
65                  70                  75                  80  


Pro Trp Trp Gly Ser Ile Leu Leu Ser Thr Val Ala Leu Arg Gly Ala 
                85                  90                  95      


Val Thr Leu Pro Leu Ala Ala Tyr Gln His Tyr Ile Leu Ala Lys Val 
            100                 105                 110         


Glu Asn Leu Gln Pro Glu Ile Lys Thr Ile Ala Arg His Leu Asn Gln 
        115                 120                 125             


Glu Val Ala Val Arg Ala Asn Gln Leu Gly Trp Ser Lys Arg Asp Ala 
    130                 135                 140                 


Arg Leu Thr Tyr Leu Lys Asn Met Arg Arg Leu Ile Ser Glu Leu Tyr 
145                 150                 155                 160 


Val Arg Asp Asn Cys His Pro Phe Lys Ala Thr Val Leu Val Trp Ile 
                165                 170                 175     


Gln Leu Pro Met Trp Ile Phe Met Ser Phe Ala Leu Arg Asn Leu Ser 
            180                 185                 190         


Thr Gly Ala Ala His Ser Glu Gly Phe Ser Val Gln Glu Gln Leu Ala 
        195                 200                 205             


Thr Gly Gly Ile Leu Trp Phe Pro Asp Leu Thr Ala Pro Asp Ser Thr 
    210                 215                 220                 


Trp Ile Leu Pro Ile Ser Val Gly Val Ile Asn Leu Leu Ile Val Glu 
225                 230                 235                 240 


Ile Cys Ala Leu Gln Lys Ile Gly Met Ser Arg Phe Gln Thr Tyr Ile 
                245                 250                 255     


Thr Tyr Phe Val Arg Ala Met Ser Val Leu Met Ile Pro Ile Ala Ala 
            260                 265                 270         


Thr Val Pro Ser Ser Ile Val Leu Tyr Trp Leu Cys Ser Ser Phe Val 
        275                 280                 285             


Gly Leu Ser Gln Asn Leu Leu Leu Arg Ser Pro Gly Phe Arg Gln Leu 
    290                 295                 300                 


Cys Arg Ile Pro Ser Thr Lys Ser Asp Ser Glu Thr Pro Tyr Lys Asp 
305                 310                 315                 320 


Ile Phe Ala Ala Phe Asn Thr Lys Phe Ile Ser Arg Lys 
                325                 330             


<210>  6391
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  6391

Met Ser Glu Pro Gln Pro Asp Leu Glu Pro Pro Gln His Gly Leu Tyr 
1               5                   10                  15      


Met Leu Phe Leu Leu Val Leu Val Phe Phe Leu Met Gly Leu Val Gly 
            20                  25                  30          


Phe Met Ile Cys His Val Leu Lys Lys Lys Gly Tyr Arg Cys Arg Thr 
        35                  40                  45              


Ser Arg Gly Ser Glu Pro Asp Asp Ala Gln Leu Gln Pro Pro Glu Asp 
    50                  55                  60                  


Asp Asp Met Asn Glu Asp Thr Val Glu Arg Ile Val Arg Cys Ile Ile 
65                  70                  75                  80  


Gln Asn Glu Ala Asn Ala Glu Ala Leu Lys Glu Met Leu Gly Asp Ser 
                85                  90                  95      


Glu Gly Glu Gly Thr Val Gln Leu Ser Ser Val Asp Ala Thr Ser Ser 
            100                 105                 110         


Leu Gln Asp Gly Ala Pro Ser His His His Thr Val His Leu Gly Ser 
        115                 120                 125             


Ala Ala Pro Cys Leu His Cys Ser Arg Ser Lys Arg Pro Pro Leu Val 
    130                 135                 140                 


Arg Gln Gly Arg Ser Lys Glu Gly Lys Ser Arg Pro Arg Thr Gly Glu 
145                 150                 155                 160 


Thr Thr Val Phe Ser Val Gly Arg Phe Arg Val Thr His Ile Glu Lys 
                165                 170                 175     


Arg Tyr Gly Leu His Glu His Arg Asp Gly Ser Pro Thr Asp Arg Ser 
            180                 185                 190         


Trp Gly Ser Gly Gly Gly Gln Asp Pro Gly Gly Gly Gln Gly Ser Gly 
        195                 200                 205             


Gly Gly Gln Pro Lys Ala Gly Met Pro Ala Met Glu Arg Leu Pro Pro 
    210                 215                 220                 


Glu Arg Pro Gln Pro Gln Val Leu Ala Ser Pro Pro Val Gln Asn Gly 
225                 230                 235                 240 


Gly Leu Arg Asp Ser Ser Leu Thr Pro Arg Ala Leu Glu Gly Asn Pro 
                245                 250                 255     


Arg Ala Ser Ala Glu Pro Thr Leu Arg Ala Gly Gly Arg Gly Pro Ser 
            260                 265                 270         


Pro Gly Leu Pro Thr Gln Glu Ala Asn Gly Gln Pro Ser Lys Pro Asp 
        275                 280                 285             


Thr Ser Asp His Gln Val Ser Leu Pro Gln Gly Ala Gly Ser Met 
    290                 295                 300             


<210>  6392
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  6392

Met Glu Asn Lys Ala Met Tyr Leu His Thr Val Ser Asp Cys Asp Thr 
1               5                   10                  15      


Ser Ser Ile Cys Glu Asp Ser Phe Asp Gly Arg Ser Leu Ser Lys Leu 
            20                  25                  30          


Asn Leu Cys Glu Asp Gly Pro Cys His Lys Arg Arg Ala Ser Ile Cys 
        35                  40                  45              


Cys Thr Gln Leu Gly Ser Leu Ser Ala Leu Lys His Ala Val Leu Gly 
    50                  55                  60                  


Leu Tyr Leu Leu Val Phe Leu Ile Leu Val Gly Ile Phe Ile Leu Ala 
65                  70                  75                  80  


Val Ser Arg Pro Arg Ser Ser Pro Asp Asp Leu Lys Ala Leu Thr Arg 
                85                  90                  95      


Asn Val Asn Arg Leu Asn Glu Ser Phe Arg Asp Leu Gln Leu Arg Leu 
            100                 105                 110         


Leu Gln Ala Pro Leu Gln Ala Asp Leu Thr Glu Gln Val Trp Lys Val 
        115                 120                 125             


Gln Asp Ala Leu Gln Asn Gln Ser Asp Ser Leu Leu Ala Leu Ala Gly 
    130                 135                 140                 


Ala Val Gln Arg Leu Glu Gly Ala Leu Trp Gly Leu Gln Ala Gln Ala 
145                 150                 155                 160 


Val Gln Thr Glu Gln Ala Val Ala Leu Leu Arg Asp Arg Thr Gly Gln 
                165                 170                 175     


Gln Ser Asp Thr Ala Gln Leu Glu Leu Tyr Gln Leu Gln Val Glu Ser 
            180                 185                 190         


Asn Ser Ser Gln Leu Leu Leu Arg Arg His Ala Gly Leu Leu Asp Gly 
        195                 200                 205             


Leu Ala Arg Arg Val Gly Ile Leu Gly Glu Glu Leu Ala Asp Val Gly 
    210                 215                 220                 


Gly Val Leu Arg Gly Leu Asn His Ser Leu Ser Tyr Asp Val Ala Leu 
225                 230                 235                 240 


His Arg Thr Arg Leu Gln Asp Leu Arg Val Leu Val Ser Asn Ala Ser 
                245                 250                 255     


Glu Asp Thr Arg Arg Leu Arg Leu Ala His Val Gly Met Glu Leu Gln 
            260                 265                 270         


Leu Lys Gln Glu Leu Ala Met Leu Asn Ala Val Thr Glu Asp Leu Arg 
        275                 280                 285             


Leu Lys Asp Trp Glu His Ser Ile Ala Leu Arg Asn Ile Ser Leu Ala 
    290                 295                 300                 


Lys Gly Pro Pro Gly Pro Lys Gly Asp Gln Gly Asp Glu Gly Lys Glu 
305                 310                 315                 320 


Gly Arg Pro Gly Ile Pro Gly Leu Pro Gly Leu Arg Gly Leu Pro Gly 
                325                 330                 335     


Glu Arg Gly Thr Pro Gly Leu Pro Gly Pro Lys Gly Asp Asp Gly Lys 
            340                 345                 350         


Leu Gly Ala Thr Gly Pro Met Gly Met Arg Gly Phe Lys Gly Asp Arg 
        355                 360                 365             


Gly Pro Lys Gly Glu Lys Gly Glu Lys Gly Asp Arg Ala Gly Asp Ala 
    370                 375                 380                 


Ser Gly Val Glu Ala Pro Met Met Ile Arg Leu Val Asn Gly Ser Gly 
385                 390                 395                 400 


Pro His Glu Gly Arg Val Glu Val Tyr His Asp Arg Arg Trp Gly Thr 
                405                 410                 415     


Val Cys Asp Asp Gly Trp Asp Lys Lys Asp Gly Asp Val Val Cys Arg 
            420                 425                 430         


Met Leu Gly Phe Arg Gly Val Glu Glu Val Tyr Arg Thr Ala Arg Phe 
        435                 440                 445             


Gly Gln Gly Thr Gly Arg Ile Trp Met Asp Asp Val Ala Cys Lys Gly 
    450                 455                 460                 


Thr Glu Glu Thr Ile Phe Arg Cys Ser Phe Ser Lys Trp Gly Val Thr 
465                 470                 475                 480 


Asn Cys Gly His Ala Glu Asp Ala Ser Val Thr Cys Asn Arg His 
                485                 490                 495 


<210>  6393
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  6393

Met Ala Glu Ala Glu Glu Ser Pro Gly Asp Pro Gly Thr Ala Ser Pro 
1               5                   10                  15      


Arg Pro Leu Phe Ala Gly Leu Ser Asp Ile Ser Ile Ser Gln Asp Ile 
            20                  25                  30          


Pro Val Glu Gly Glu Ile Thr Ile Pro Met Arg Ser Arg Ile Arg Glu 
        35                  40                  45              


Phe Asp Ser Ser Thr Leu Asn Glu Ser Val Arg Asn Thr Ile Met Arg 
    50                  55                  60                  


Asp Leu Lys Ala Val Gly Lys Lys Phe Met His Val Leu Tyr Pro Arg 
65                  70                  75                  80  


Lys Ser Asn Thr Leu Leu Arg Asp Trp Asp Leu Trp Gly Pro Leu Ile 
                85                  90                  95      


Leu Cys Val Thr Leu Ala Leu Met Leu Gln Arg Asp Ser Ala Asp Ser 
            100                 105                 110         


Glu Lys Asp Gly Gly Pro Gln Phe Ala Glu Val Phe Val Ile Val Trp 
        115                 120                 125             


Phe Gly Ala Val Thr Ile Thr Leu Asn Ser Lys Leu Leu Gly Gly Asn 
    130                 135                 140                 


Ile Ser Phe Phe Gln Ser Leu Cys Val Leu Gly Tyr Cys Ile Leu Pro 
145                 150                 155                 160 


Leu Thr Val Ala Met Leu Ile Cys Arg Leu Val Leu Leu Ala Asp Pro 
                165                 170                 175     


Gly Pro Val Asn Phe Met Val Arg Leu Phe Val Val Ile Val Met Phe 
            180                 185                 190         


Ala Trp Ser Ile Val Ala Ser Thr Ala Phe Leu Ala Asp Ser Gln Pro 
        195                 200                 205             


Pro Asn Arg Arg Ala Leu Ala Val Tyr Pro Val Phe Leu Phe Tyr Phe 
    210                 215                 220                 


Val Ile Ser Trp Met Ile Leu Thr Phe Thr Pro Gln 
225                 230                 235     


<210>  6394
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  6394

Met Glu Phe Leu Glu Arg Thr Tyr Leu Val Asn Asp Lys Ala Ala Lys 
1               5                   10                  15      


Met Tyr Ala Phe Thr Leu Glu Ser Val Glu Leu Gln Gln Lys Pro Val 
            20                  25                  30          


Asn Lys Asp Gln Cys Pro Arg Glu Arg Pro Glu Glu Leu Glu Ser Gly 
        35                  40                  45              


Gly Met Tyr His Cys His Ser Gly Ser Lys Pro Thr Glu Lys Gly Ala 
    50                  55                  60                  


Asn Glu Tyr Ala Tyr Ala Lys Trp Lys Leu Cys Ser Ala Ser Ala Ile 
65                  70                  75                  80  


Cys Phe Ile Phe Met Ile Ala Glu Val Val Gly Gly His Ile Ala Gly 
                85                  90                  95      


Ser Leu Ala Val Val Thr Asp Ala Ala His Leu Leu Ile Asp Leu Thr 
            100                 105                 110         


Ser Phe Leu Leu Ser Leu Phe Ser Leu Trp Leu Ser Ser Lys Pro Pro 
        115                 120                 125             


Ser Lys Arg Leu Thr Phe Gly Trp His Arg Ala Glu Ile Leu Gly Ala 
    130                 135                 140                 


Leu Leu Ser Ile Leu Cys Ile Trp Val Val Thr Gly Val Leu Val Tyr 
145                 150                 155                 160 


Leu Ala Cys Glu Arg Leu Leu Tyr Pro Asp Tyr Gln Ile Gln Ala Thr 
                165                 170                 175     


Val Met Ile Ile Val Ser Ser Cys Ala Val Ala Ala Asn Ile Val Leu 
            180                 185                 190         


Thr Val Val Leu His Gln Arg Cys Leu Gly His Asn His Lys Glu Val 
        195                 200                 205             


Gln Ala Asn Ala Ser Val Arg Ala Ala Phe Val His Ala Leu Gly Asp 
    210                 215                 220                 


Leu Phe Gln Ser Ile Ser Val Leu Ile Ser Ala Leu Ile Ile Tyr Phe 
225                 230                 235                 240 


Lys Pro Glu Tyr Lys Ile Ala Asp Pro Ile Cys Thr Phe Ile Phe Ser 
                245                 250                 255     


Ile Leu Val Leu Ala Ser Thr Ile Thr Ile Leu Lys Asp Phe Ser Ile 
            260                 265                 270         


Leu Leu Met Glu Gly Val Pro Lys Ser Leu Asn Tyr Ser Gly Val Lys 
        275                 280                 285             


Glu Leu Ile Leu Ala Val Asp Gly Val Leu Ser Val His Ser Leu His 
    290                 295                 300                 


Ile Trp Ser Leu Thr Met Asn Gln Val Ile Leu Ser Ala His Val Ala 
305                 310                 315                 320 


Thr Ala Ala Ser Arg Asp Ser Gln Val Val Arg Arg Glu Ile Ala Lys 
                325                 330                 335     


Ala Leu Ser Lys Ser Phe Thr Met His Ser Leu Thr Ile Gln Met Glu 
            340                 345                 350         


Ser Pro Val Asp Gln Asp Pro Asp Cys Leu Phe Cys Glu Asp Pro Cys 
        355                 360                 365             


Asp 
    


<210>  6395
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  6395

Met Arg Ile Ala Asn Arg Thr Arg Phe Ser Ser Pro Phe Leu Ala Arg 
1               5                   10                  15      


Gly Ala Gly Trp Thr His Gly Arg Gly Met Met Val Val Gly Thr Gly 
            20                  25                  30          


Thr Ser Leu Ala Leu Ser Ser Leu Leu Ser Leu Leu Leu Phe Ala Gly 
        35                  40                  45              


Met Gln Met Tyr Ser Arg Gln Leu Ala Ser Thr Glu Trp Leu Thr Ile 
    50                  55                  60                  


Gln Gly Gly Leu Leu Gly Ser Gly Leu Phe Val Phe Ser Leu Thr Ala 
65                  70                  75                  80  


Phe Asn Asn Leu Glu Asn Leu Val Phe Gly Lys Gly Phe Gln Ala Lys 
                85                  90                  95      


Ile Phe Pro Glu Ile Leu Leu Cys Leu Leu Leu Ala Leu Phe Ala Ser 
            100                 105                 110         


Gly Leu Ile His Arg Val Cys Val Thr Thr Cys Phe Ile Phe Ser Met 
        115                 120                 125             


Val Gly Leu Tyr Tyr Ile Asn Lys Ile Ser Ser Thr Leu Tyr Gln Ala 
    130                 135                 140                 


Ala Ala Pro Val Leu Thr Pro Ala Lys Val Thr Gly Lys Ser Lys Lys 
145                 150                 155                 160 


Arg Asn 
        


<210>  6396
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  6396

Met Arg Arg Cys Ser Leu Cys Ala Phe Asp Ala Ala Arg Gly Pro Arg 
1               5                   10                  15      


Arg Leu Met Arg Val Gly Leu Ala Leu Ile Leu Val Gly His Val Asn 
            20                  25                  30          


Leu Leu Leu Gly Ala Val Leu His Gly Thr Val Leu Arg His Val Ala 
        35                  40                  45              


Asn Pro Arg Gly Ala Val Thr Pro Glu Tyr Thr Val Ala Asn Val Ile 
    50                  55                  60                  


Ser Val Gly Ser Gly Leu Leu Ser Val Ser Val Gly Leu Val Ala Leu 
65                  70                  75                  80  


Leu Ala Ser Arg Asn Leu Leu Arg Pro Pro Leu His Trp Val Leu Leu 
                85                  90                  95      


Ala Leu Ala Leu Val Asn Leu Leu Leu Ser Val Ala Cys Ser Leu Gly 
            100                 105                 110         


Leu Leu Leu Ala Val Ser Leu Thr Val Ala Asn Gly Gly Arg Arg Leu 
        115                 120                 125             


Ile Ala Asp Cys His Pro Gly Leu Leu Asp Pro Leu Val Pro Leu Asp 
    130                 135                 140                 


Glu Gly Pro Gly His Thr Asp Cys Pro Phe Asp Pro Thr Arg Ile Tyr 
145                 150                 155                 160 


Asp Thr Ala Leu Ala Leu Trp Ile Pro Ser Leu Leu Met Ser Ala Gly 
                165                 170                 175     


Glu Ala Ala Leu Ser Gly Tyr Cys Cys Val Ala Ala Leu Thr Leu Arg 
            180                 185                 190         


Gly Val Gly Pro Cys Arg Lys Asp Gly Leu Gln Gly Gln Leu Glu Glu 
        195                 200                 205             


Met Thr Glu Leu Glu Ser Pro Lys Cys Lys Arg Gln Glu Asn Glu Gln 
    210                 215                 220                 


Leu Leu Asp Gln Asn Gln Glu Ile Arg Ala Ser Gln Arg Ser Trp Val 
225                 230                 235                 240 


<210>  6397
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  6397

Met Ser Ser Lys Pro Glu Pro Lys Asp Val His Gln Leu Asn Gly Thr 
1               5                   10                  15      


Gly Pro Ser Ala Ser Pro Cys Ser Ser Asp Gly Pro Gly Arg Glu Pro 
            20                  25                  30          


Leu Ala Gly Thr Ser Glu Phe Leu Gly Pro Asp Gly Ala Gly Val Glu 
        35                  40                  45              


Val Val Ile Glu Ser Arg Ala Asn Ala Lys Gly Val Arg Glu Glu Asp 
    50                  55                  60                  


Ala Leu Leu Glu Asn Gly Ser Gln Ser Asn Glu Ser Asp Asp Val Ser 
65                  70                  75                  80  


Thr Asp Arg Gly Pro Ala Pro Pro Ser Pro Leu Lys Glu Thr Ser Phe 
                85                  90                  95      


Ser Ile Gly Leu Gln Val Leu Phe Pro Phe Leu Leu Ala Gly Phe Gly 
            100                 105                 110         


Thr Val Ala Ala Gly Met Val Leu Asp Ile Val Gln His Trp Glu Val 
        115                 120                 125             


Phe Gln Lys Val Thr Glu Val Phe Ile Leu Val Pro Ala Leu Leu Gly 
    130                 135                 140                 


Leu Lys Gly Asn Leu Glu Met Thr Leu Ala Ser Arg Leu Ser Thr Ala 
145                 150                 155                 160 


Ala Asn Ile Gly His Met Asp Thr Pro Lys Glu Leu Trp Arg Met Ile 
                165                 170                 175     


Thr Gly Asn Met Ala Leu Ile Gln Val Gln Ala Thr Val Val Gly Phe 
            180                 185                 190         


Leu Ala Ser Ile Ala Ala Val Val Phe Gly Trp Ile Pro Asp Gly His 
        195                 200                 205             


Phe Ser Ile Pro His Ala Phe Leu Leu Cys Ala Ser Ser Val Ala Thr 
    210                 215                 220                 


Ala Phe Ile Ala Ser Leu Val Leu Gly Met Ile Met Ile Gly Val Ile 
225                 230                 235                 240 


Ile Gly Ser Arg Lys Ile Gly Ile Asn Pro Asp Asn Val Ala Thr Pro 
                245                 250                 255     


Ile Ala Ala Ser Leu Gly Asp Leu Ile Thr Leu Ala Leu Leu Ser Gly 
            260                 265                 270         


Ile Ser Trp Gly Leu Tyr Leu Glu Leu Asn His Trp Arg Tyr Ile Tyr 
        275                 280                 285             


Pro Leu Val Cys Ala Phe Phe Val Ala Leu Leu Pro Val Trp Val Val 
    290                 295                 300                 


Leu Ala Arg Arg Ser Pro Ala Thr Arg Glu Val Leu Tyr Ser Gly Trp 
305                 310                 315                 320 


Glu Pro Val Ile Ile Ala Met Ala Ile Ser Ser Val Gly Gly Leu Ile 
                325                 330                 335     


Leu Asp Lys Thr Val Ser Asp Pro Asn Phe Ala Gly Met Ala Val Phe 
            340                 345                 350         


Thr Pro Val Ile Asn Gly Val Gly Gly Asn Leu Val Ala Val Gln Ala 
        355                 360                 365             


Ser Arg Ile Ser Thr Phe Leu His Met Asn Gly Met Pro Gly Glu Asn 
    370                 375                 380                 


Ser Glu Gln Ala Pro Arg Arg Cys Pro Ser Pro Cys Thr Thr Phe Phe 
385                 390                 395                 400 


Ser Pro Asp Val Asn Ser Arg Ser Ala Arg Val Leu Phe Leu Leu Val 
                405                 410                 415     


Val Pro Gly His Leu Val Phe Leu Tyr Thr Ile Ser Cys Met Gln Gly 
            420                 425                 430         


Gly His Thr Thr Leu Thr Leu Ile Phe Ile Ile Phe Tyr Met Thr Ala 
        435                 440                 445             


Ala Leu Leu Gln Val Leu Ile Leu Leu Tyr Ile Ala Asp Trp Met Val 
    450                 455                 460                 


His Trp Met Trp Gly Arg Gly Leu Asp Pro Asp Asn Phe Ser Ile Pro 
465                 470                 475                 480 


Tyr Leu Thr Ala Leu Gly Asp Leu Leu Gly Thr Gly Leu Leu Ala Leu 
                485                 490                 495     


Ser Phe His Val Leu Trp Leu Ile Gly Asp Arg Asp Thr Asp Val Gly 
            500                 505                 510         


Asp 
    


<210>  6398
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  6398

Met Thr His Thr Leu Tyr Pro Thr Pro Phe Ala Leu Tyr Pro Ile Asn 
1               5                   10                  15      


Ile Ser Ala Ala Trp His Leu Gly Pro Leu Pro Val Ser Cys Phe Val 
            20                  25                  30          


Ser Asn Lys Tyr Gln Cys Ser Leu Ala Phe Gly Ala Thr Thr Gly Leu 
        35                  40                  45              


Arg Val Leu Val Val Val Val Pro Gln Thr Gln Leu Ser Phe Leu Ser 
    50                  55                  60                  


Ser Leu Cys Leu Val Ser Leu Phe Leu His Ser Leu Val Ser Ala His 
65                  70                  75                  80  


Gly Glu Lys Pro Thr Lys Pro Val Gly Leu Asp Pro Thr Leu Phe Gln 
                85                  90                  95      


Val Val Val Gly Ile Leu Gly Asn Phe Ser Leu Leu Tyr Tyr Tyr Met 
            100                 105                 110         


Phe Leu Tyr Phe Arg Gly Tyr Lys Pro Arg Ser Thr Asp Leu Ile Leu 
        115                 120                 125             


Arg His Leu Thr Val Ala Asp Ser Leu Val Ile Leu Ser Lys Arg Ile 
    130                 135                 140                 


Pro Glu Thr Met Ala Thr Phe Gly Leu Lys His Phe Asp Asn Tyr Phe 
145                 150                 155                 160 


Gly Cys Lys Phe Leu Leu Tyr Ala His Arg Val Gly Arg Gly Val Ser 
                165                 170                 175     


Ile Gly Ser Thr Cys Leu Leu Ser Val Phe Gln Val Ile Thr Ile Asn 
            180                 185                 190         


Pro Arg Asn Ser Arg Trp Ala Glu Met Lys Val Lys Ala Pro Thr Tyr 
        195                 200                 205             


Ile Gly Leu Ser Asn Ile Leu Cys Trp Ala Phe His Met Leu Val Asn 
    210                 215                 220                 


Ala Ile Phe Pro Ile Tyr Thr Thr Gly Lys Trp Ser Asn Asn Asn Ile 
225                 230                 235                 240 


Thr Lys Lys Gly Asp Leu Gly Tyr Cys Ser Ala Pro Leu Ser Asp Glu 
                245                 250                 255     


Val Thr Lys Ser Val Tyr Ala Ala Leu Thr Ser Phe His Asp Val Leu 
            260                 265                 270         


Cys Leu Gly Leu Met Leu Trp Ala Ser Ser Ser Ile Val Leu Val Leu 
        275                 280                 285             


Tyr Arg His Lys Gln Gln Val Gln His Ile Cys Arg Asn Asn Leu Tyr 
    290                 295                 300                 


Pro Asn Ser Ser Pro Gly Asn Arg Ala Ile Gln Ser Ile Leu Ala Leu 
305                 310                 315                 320 


Val Ser Thr Phe Ala Leu Cys Tyr Ala Leu Ser Phe Ile Thr Tyr Val 
                325                 330                 335     


Tyr Leu Ala Leu Phe Asp Asn Ser Ser Trp Trp Leu Val Asn Thr Ala 
            340                 345                 350         


Ala Leu Ile Ile Ala Cys Phe Pro Thr Ile Ser Pro Phe Val Leu Met 
        355                 360                 365             


Cys Arg Asp Pro Ser Arg Ser Arg Leu Cys Ser Ile Cys Cys Arg Arg 
    370                 375                 380                 


Asn Arg Arg Phe Phe His Asp Phe Arg Lys Met 
385                 390                 395 


<210>  6399
<211>  866
<212>  PRT
<213>  Homo sapiens

<400>  6399

Met Glu Ser Glu Gln Leu Phe His Arg Gly Tyr Tyr Arg Asn Ser Tyr 
1               5                   10                  15      


Asn Ser Ile Thr Ser Ala Ser Ser Asp Glu Glu Leu Leu Asp Gly Ala 
            20                  25                  30          


Gly Val Ile Met Asp Phe Gln Thr Ser Glu Asp Asp Asn Leu Leu Asp 
        35                  40                  45              


Gly Asp Thr Ala Val Gly Thr His Tyr Thr Met Thr Asn Gly Gly Ser 
    50                  55                  60                  


Ile Asn Ser Ser Thr His Leu Leu Asp Leu Leu Asp Glu Pro Ile Pro 
65                  70                  75                  80  


Gly Val Gly Thr Tyr Asp Asp Phe His Thr Ile Asp Trp Val Arg Glu 
                85                  90                  95      


Lys Cys Lys Asp Arg Glu Arg His Arg Arg Ile Asn Ser Lys Lys Lys 
            100                 105                 110         


Glu Ser Ala Trp Glu Met Thr Lys Ser Leu Tyr Asp Ala Trp Ser Gly 
        115                 120                 125             


Trp Leu Val Val Thr Leu Thr Gly Leu Ala Ser Gly Ala Leu Ala Gly 
    130                 135                 140                 


Leu Ile Asp Ile Ala Ala Asp Trp Met Thr Asp Leu Lys Glu Gly Ile 
145                 150                 155                 160 


Cys Leu Ser Ala Leu Trp Tyr Asn His Glu Gln Cys Cys Trp Gly Ser 
                165                 170                 175     


Asn Glu Thr Thr Phe Glu Glu Arg Asp Lys Cys Pro Gln Trp Lys Thr 
            180                 185                 190         


Trp Ala Glu Leu Ile Ile Gly Gln Ala Glu Gly Pro Gly Ser Tyr Ile 
        195                 200                 205             


Met Asn Tyr Ile Met Tyr Ile Phe Trp Ala Leu Ser Phe Ala Phe Leu 
    210                 215                 220                 


Ala Val Ser Leu Val Lys Val Phe Ala Pro Tyr Ala Cys Gly Ser Gly 
225                 230                 235                 240 


Ile Pro Glu Ile Lys Thr Ile Leu Ser Gly Phe Ile Ile Arg Gly Tyr 
                245                 250                 255     


Leu Gly Lys Trp Thr Leu Met Ile Lys Thr Ile Thr Leu Val Leu Ala 
            260                 265                 270         


Val Ala Ser Gly Leu Ser Leu Gly Lys Glu Gly Pro Leu Val His Val 
        275                 280                 285             


Ala Cys Cys Cys Gly Asn Ile Phe Ser Tyr Leu Phe Pro Lys Tyr Ser 
    290                 295                 300                 


Thr Asn Glu Ala Lys Lys Arg Glu Val Leu Ser Ala Ala Ser Ala Ala 
305                 310                 315                 320 


Gly Val Ser Val Ala Phe Gly Ala Pro Ile Gly Gly Val Leu Phe Ser 
                325                 330                 335     


Leu Glu Glu Val Ser Tyr Tyr Phe Pro Leu Lys Thr Leu Trp Arg Ser 
            340                 345                 350         


Phe Phe Ala Ala Leu Val Ala Ala Phe Val Leu Arg Ser Ile Asn Pro 
        355                 360                 365             


Phe Gly Asn Ser Arg Leu Val Leu Phe Tyr Val Glu Tyr His Thr Pro 
    370                 375                 380                 


Trp Tyr Leu Phe Glu Leu Phe Pro Phe Ile Leu Leu Gly Val Phe Gly 
385                 390                 395                 400 


Gly Leu Trp Gly Ala Phe Phe Ile Arg Ala Asn Ile Ala Trp Cys Arg 
                405                 410                 415     


Arg Arg Lys Ser Thr Lys Phe Gly Lys Tyr Pro Val Leu Glu Val Ile 
            420                 425                 430         


Ile Val Ala Ala Ile Thr Ala Val Ile Ala Phe Pro Asn Pro Tyr Thr 
        435                 440                 445             


Arg Leu Asn Thr Ser Glu Leu Ile Lys Glu Leu Phe Thr Asp Cys Gly 
    450                 455                 460                 


Pro Leu Glu Ser Ser Ser Leu Cys Asp Tyr Arg Asn Asp Met Asn Ala 
465                 470                 475                 480 


Ser Lys Ile Val Asp Asp Ile Pro Asp Arg Pro Ala Gly Ile Gly Val 
                485                 490                 495     


Tyr Ser Ala Ile Trp Gln Leu Cys Leu Ala Leu Ile Phe Lys Ile Ile 
            500                 505                 510         


Met Thr Val Phe Thr Phe Gly Ile Lys Val Pro Ser Gly Leu Phe Ile 
        515                 520                 525             


Pro Ser Met Ala Ile Gly Ala Ile Ala Gly Arg Ile Val Gly Ile Ala 
    530                 535                 540                 


Val Glu Gln Leu Ala Tyr Tyr His His Asp Trp Phe Ile Phe Lys Glu 
545                 550                 555                 560 


Trp Cys Glu Val Gly Ala Asp Cys Ile Thr Pro Gly Leu Tyr Ala Met 
                565                 570                 575     


Val Gly Ala Ala Ala Cys Leu Gly Gly Val Thr Arg Met Thr Val Ser 
            580                 585                 590         


Leu Val Val Ile Val Phe Glu Leu Thr Gly Gly Leu Glu Tyr Ile Val 
        595                 600                 605             


Pro Leu Met Ala Ala Val Met Thr Ser Lys Trp Val Gly Asp Ala Phe 
    610                 615                 620                 


Gly Arg Glu Gly Ile Tyr Glu Ala His Ile Arg Leu Asn Gly Tyr Pro 
625                 630                 635                 640 


Phe Leu Asp Ala Lys Glu Glu Phe Thr His Thr Thr Leu Ala Ala Asp 
                645                 650                 655     


Val Met Arg Pro Arg Arg Asn Asp Pro Pro Leu Ala Val Leu Thr Gln 
            660                 665                 670         


Asp Asn Met Thr Val Asp Asp Ile Glu Asn Met Ile Asn Glu Thr Ser 
        675                 680                 685             


Tyr Asn Gly Phe Pro Val Ile Met Ser Lys Glu Ser Gln Arg Leu Val 
    690                 695                 700                 


Gly Phe Ala Leu Arg Arg Asp Leu Thr Ile Ala Ile Glu Ser Ala Arg 
705                 710                 715                 720 


Lys Lys Gln Glu Gly Ile Val Gly Ser Ser Arg Val Cys Phe Ala Gln 
                725                 730                 735     


His Thr Pro Ser Leu Pro Ala Glu Ser Pro Arg Pro Leu Lys Leu Arg 
            740                 745                 750         


Ser Ile Leu Asp Met Ser Pro Phe Thr Val Thr Asp His Thr Pro Met 
        755                 760                 765             


Glu Ile Val Val Asp Ile Phe Arg Lys Leu Gly Leu Arg Gln Cys Leu 
    770                 775                 780                 


Val Thr His Asn Gly Ile Val Leu Gly Ile Ile Thr Lys Lys Asn Ile 
785                 790                 795                 800 


Leu Glu His Leu Glu Gln Leu Lys Gln His Val Glu Pro Leu Ala Pro 
                805                 810                 815     


Pro Trp His Tyr Asn Lys Lys Arg Tyr Pro Pro Ala Tyr Gly Pro Asp 
            820                 825                 830         


Gly Lys Pro Arg Pro Arg Phe Asn Asn Val Gln Leu Asn Leu Thr Asp 
        835                 840                 845             


Glu Glu Arg Glu Glu Thr Glu Glu Glu Val Tyr Leu Leu Asn Ser Thr 
    850                 855                 860                 


Thr Leu 
865     


<210>  6400
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  6400

Met Ala Ala Ala Gln Pro Lys Tyr Pro Ala Gly Ala Thr Ala Arg Arg 
1               5                   10                  15      


Leu Ala Arg Gly Cys Trp Ser Ala Leu Trp Asp Tyr Glu Thr Pro Lys 
            20                  25                  30          


Val Ile Val Ser Ile Arg Val His Asn Ala Thr Cys Leu Ser Asp Ala 
        35                  40                  45              


Asp Cys Val Ala Gly Glu Leu Asp Met Leu Gly Asn Gly Leu Arg Thr 
    50                  55                  60                  


Gly Arg Cys Val Pro Tyr Tyr Gln Gly Pro Ser Lys Thr Cys Glu Val 
65                  70                  75                  80  


Phe Gly Trp Cys Pro Val Glu Asp Gly Ala Ser Val Ser Gln Phe Leu 
                85                  90                  95      


Gly Thr Met Ala Pro Asn Phe Thr Ile Leu Ile Lys Asn Ser Ile His 
            100                 105                 110         


Tyr Pro Lys Phe His Phe Ser Lys Gly Asn Ile Ala Asp Arg Thr Asp 
        115                 120                 125             


Gly Tyr Leu Lys Arg Cys Thr Phe His Glu Ala Ser Asp Leu Tyr Cys 
    130                 135                 140                 


Pro Ile Phe Lys Leu Gly Phe Ile Val Glu Lys Ala Gly Glu Ser Phe 
145                 150                 155                 160 


Thr Glu Leu Ala His Lys Gly Gly Val Ile Gly Val Ile Ile Asn Trp 
                165                 170                 175     


Asp Cys Asp Leu Asp Leu Pro Ala Ser Glu Cys Asn Pro Lys Tyr Ser 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Lys His Val Pro Ala Ser Ser Gly Tyr Asn 
        195                 200                 205             


Phe Arg Phe Ala Lys Tyr Tyr Lys Ile Asn Gly Thr Thr Thr Arg Thr 
    210                 215                 220                 


Leu Ile Lys Ala Tyr Gly Ile Arg Ile Asp Val Ile Val His Gly Gln 
225                 230                 235                 240 


Ala Gly Lys Phe Ser Leu Ile Pro Thr Ile Ile Asn Leu Ala Thr Ala 
                245                 250                 255     


Leu Thr Ser Val Gly Val Gly Ser Phe Leu Cys Asp Trp Ile Leu Leu 
            260                 265                 270         


Thr Phe Met Asn Lys Asn Lys Val Tyr Ser His Lys Lys Phe Asp Lys 
        275                 280                 285             


Val Cys Thr Pro Ser His Pro Ser Gly Ser Trp Pro Val Thr Leu Ala 
    290                 295                 300                 


Arg Val Leu Gly Gln Ala Pro Pro Glu Pro Gly His Arg Ser Glu Asp 
305                 310                 315                 320 


Gln His Pro Ser Pro Pro Ser Gly Gln Glu Gly Gln Gln Gly Ala Glu 
                325                 330                 335     


Cys Gly Pro Ala Phe Pro Pro Leu Arg Pro Cys Pro Ile Ser Ala Pro 
            340                 345                 350         


Ser Glu Gln Met Val Asp Thr Pro Ala Ser Glu Pro Ala Gln Ala Ser 
        355                 360                 365             


Thr Pro Thr Asp Pro Lys Gly Leu Ala Gln Leu 
    370                 375                 


<210>  6401
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  6401

Met Ala Ala Ala Gln Pro Lys Tyr Pro Ala Gly Ala Thr Ala Arg Arg 
1               5                   10                  15      


Leu Ala Arg Gly Cys Trp Ser Ala Leu Trp Asp Tyr Glu Thr Pro Lys 
            20                  25                  30          


Val Ile Val Val Arg Asn Arg Arg Leu Gly Val Leu Tyr Arg Ala Val 
        35                  40                  45              


Gln Leu Leu Ile Leu Leu Tyr Phe Val Trp Tyr Val Phe Ile Val Gln 
    50                  55                  60                  


Lys Ser Tyr Gln Glu Ser Glu Thr Gly Pro Glu Ser Ser Ile Ile Thr 
65                  70                  75                  80  


Lys Val Lys Gly Ile Thr Thr Ser Glu His Lys Val Trp Asp Val Glu 
                85                  90                  95      


Glu Tyr Val Lys Pro Pro Glu Gly Gly Ser Val Phe Ser Ile Ile Thr 
            100                 105                 110         


Arg Val Glu Ala Thr His Ser Gln Thr Gln Gly Thr Cys Pro Glu Ser 
        115                 120                 125             


Ile Arg Val His Asn Ala Thr Cys Leu Ser Asp Ala Asp Cys Val Ala 
    130                 135                 140                 


Gly Glu Leu Asp Met Leu Gly Asn Gly Leu Arg Thr Gly Arg Cys Val 
145                 150                 155                 160 


Pro Tyr Tyr Gln Gly Pro Ser Lys Thr Cys Glu Val Phe Gly Trp Cys 
                165                 170                 175     


Pro Val Glu Asp Gly Ala Ser Val Ser Gln Phe Leu Gly Thr Met Ala 
            180                 185                 190         


Pro Asn Phe Thr Ile Leu Ile Lys Asn Ser Ile His Tyr Pro Lys Phe 
        195                 200                 205             


His Phe Ser Lys Gly Asn Ile Ala Asp Arg Thr Asp Gly Tyr Leu Lys 
    210                 215                 220                 


Arg Cys Thr Phe His Glu Ala Ser Asp Leu Tyr Cys Pro Ile Phe Lys 
225                 230                 235                 240 


Leu Gly Phe Ile Val Glu Lys Ala Gly Glu Ser Phe Thr Glu Leu Ala 
                245                 250                 255     


His Lys Gly Gly Val Ile Gly Val Ile Ile Asn Trp Asp Cys Asp Leu 
            260                 265                 270         


Asp Leu Pro Ala Ser Glu Cys Asn Pro Lys Tyr Ser Phe Arg Arg Leu 
        275                 280                 285             


Asp Pro Lys His Val Pro Ala Ser Ser Gly Tyr Asn Phe Arg Phe Ala 
    290                 295                 300                 


Lys Tyr Tyr Lys Ile Asn Gly Thr Thr Thr Arg Thr Leu Ile Lys Ala 
305                 310                 315                 320 


Tyr Gly Ile Arg Ile Asp Val Ile Val His Gly Gln Ala Gly Lys Phe 
                325                 330                 335     


Ser Leu Ile Pro Thr Ile Ile Asn Leu Ala Thr Ala Leu Thr Ser Val 
            340                 345                 350         


Gly Val Gly Ser Phe Leu Cys Asp Trp Ile Leu Leu Thr Phe Met Asn 
        355                 360                 365             


Lys Asn Lys Val Tyr Ser His Lys Lys Phe Asp Lys Met Val Asp Thr 
    370                 375                 380                 


Pro Ala Ser Glu Pro Ala Gln Ala Ser Thr Pro Thr Asp Pro Lys Gly 
385                 390                 395                 400 


Leu Ala Gln Leu 
                


<210>  6402
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  6402

Met Pro Ser Gln Gln Lys Lys Ile Ile Phe Cys Met Ala Gly Val Phe 
1               5                   10                  15      


Ser Phe Ala Cys Ala Leu Gly Val Val Thr Ala Leu Gly Thr Pro Leu 
            20                  25                  30          


Trp Ile Lys Ala Thr Val Leu Cys Lys Thr Gly Ala Leu Leu Val Asn 
        35                  40                  45              


Ala Ser Gly Gln Glu Leu Asp Lys Phe Met Gly Glu Met Gln Tyr Gly 
    50                  55                  60                  


Leu Phe His Gly Glu Gly Val Arg Gln Cys Gly Leu Gly Ala Arg Pro 
65                  70                  75                  80  


Phe Arg Phe Ser Phe Phe Pro Asp Leu Leu Lys Ala Ile Pro Val Ser 
                85                  90                  95      


Ile His Val Asn Val Ile Leu Phe Ser Ala Ile Leu Ile Val Leu Thr 
            100                 105                 110         


Met Val Gly Thr Ala Phe Phe Met Tyr Asn Ala Phe Gly Lys Pro Phe 
        115                 120                 125             


Glu Thr Leu His Gly Pro Leu Gly Leu Tyr Leu Leu Ser Phe Ile Ser 
    130                 135                 140                 


Gly Ser Cys Gly Cys Leu Val Met Ile Leu Phe Ala Ser Glu Val Lys 
145                 150                 155                 160 


Ile His His Leu Ser Glu Lys Ile Ala Asn Tyr Lys Glu Gly Thr Tyr 
                165                 170                 175     


Val Tyr Lys Thr Gln Ser Glu Lys Tyr Thr Thr Ser Phe Trp Val Ile 
            180                 185                 190         


Phe Phe Cys Phe Phe Val His Phe Leu Asn Gly Leu Leu Ile Arg Leu 
        195                 200                 205             


Ala Gly Phe Gln Phe Pro Phe Ala Lys Ser Lys Asp Ala Glu Thr Thr 
    210                 215                 220                 


Asn Val Ala Ala Asp Leu Met Tyr 
225                 230         


<210>  6403
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  6403

Met Ala Asn Pro Gly Leu Gly Leu Leu Leu Ala Leu Gly Leu Pro Phe 
1               5                   10                  15      


Leu Leu Ala Arg Trp Gly Arg Ala Trp Gly Gln Ile Gln Thr Thr Ser 
            20                  25                  30          


Ala Asn Glu Asn Ser Thr Val Leu Pro Ser Ser Thr Ser Ser Ser Ser 
        35                  40                  45              


Asp Gly Asn Leu Arg Pro Glu Ala Ile Thr Ala Ile Ile Val Val Phe 
    50                  55                  60                  


Ser Leu Leu Ala Ala Leu Leu Leu Ala Val Gly Leu Ala Leu Leu Val 
65                  70                  75                  80  


Arg Lys Leu Arg Glu Lys Arg Gln Thr Glu Gly Thr Tyr Arg Pro Ser 
                85                  90                  95      


Ser Glu Glu Gln Phe Ser His Ala Ala Glu Ala Arg Ala Pro Gln Asp 
            100                 105                 110         


Ser Lys Glu Thr Val Gln Gly Cys Leu Pro Ile 
        115                 120             


<210>  6404
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  6404

Met Trp Leu Pro Pro Ala Leu Leu Leu Leu Ser Leu Ser Gly Cys Phe 
1               5                   10                  15      


Ser Ile Gln Gly Pro Glu Ser Val Arg Ala Pro Glu Gln Gly Ser Leu 
            20                  25                  30          


Thr Val Gln Cys His Tyr Lys Gln Gly Trp Glu Thr Tyr Ile Lys Trp 
        35                  40                  45              


Trp Cys Arg Gly Val Arg Trp Asp Thr Cys Lys Ile Leu Ile Glu Thr 
    50                  55                  60                  


Arg Gly Ser Glu Gln Gly Glu Lys Ser Asp Arg Val Ser Ile Lys Asp 
65                  70                  75                  80  


Asn Gln Lys Asp Arg Thr Phe Thr Val Thr Met Glu Gly Leu Arg Arg 
                85                  90                  95      


Asp Asp Ala Asp Val Tyr Trp Cys Gly Ile Glu Arg Arg Gly Pro Asp 
            100                 105                 110         


Leu Gly Thr Gln Val Lys Val Ile Val Asp Pro Glu Gly Ala Ala Ser 
        115                 120                 125             


Thr Thr Ala Ser Ser Pro Thr Asn Ser Asn Met Ala Val Phe Ile Gly 
    130                 135                 140                 


Ser His Lys Arg Asn His Tyr Met Leu Leu Val Phe Val Lys Val Pro 
145                 150                 155                 160 


Ile Leu Leu Ile Leu Val Thr Ala Ile Leu Trp Leu Lys Gly Ser Gln 
                165                 170                 175     


Arg Val Pro Glu Glu Pro Gly Glu Gln Pro Ile Tyr Met Asn Phe Ser 
            180                 185                 190         


Glu Pro Leu Thr Lys Asp Met Ala Thr 
        195                 200     


<210>  6405
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  6405

Met Gly Gly Asn Gly Ser Thr Cys Lys Pro Asp Thr Glu Arg Gln Gly 
1               5                   10                  15      


Thr Leu Ser Thr Ala Ala Pro Thr Thr Ser Pro Ala Pro Cys Leu Ser 
            20                  25                  30          


Asn His His Asn Lys Lys His Leu Ile Leu Ala Phe Cys Ala Gly Val 
        35                  40                  45              


Leu Leu Thr Leu Leu Leu Ile Ala Phe Ile Phe Leu Ile Ile Lys Ser 
    50                  55                  60                  


Tyr Arg Lys Tyr Arg Arg Glu Arg Leu Pro Ile Ser Pro Gly Pro Leu 
65                  70                  75                  80  


Leu Arg Trp Val Pro Leu Leu Ser Gly Thr Met Ala Asp His Ser Lys 
                85                  90                  95      


Pro Gln Ala Pro Asp Pro His Ser Asp Pro Pro Ala Lys Leu Ser Ser 
            100                 105                 110         


Ile Pro Gly Glu Ser Leu Thr Tyr Ala Ser Thr Thr Phe Lys Leu Ser 
        115                 120                 125             


Glu Glu Lys Ser Asn His Leu Ala Glu Asn His Ser Ala Asp Phe Asp 
    130                 135                 140                 


Pro Ile Val Tyr Ala Gln Ile Lys Val Thr Asn 
145                 150                 155 


<210>  6406
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  6406

Met Ala Ala Lys Asp Gln Leu Glu Val Gln Val Met Ala Ala Gln Glu 
1               5                   10                  15      


Met Glu Leu Ala Gly Lys Asp Pro Val Ser His Glu His Glu Glu Arg 
            20                  25                  30          


Lys Pro Val Thr Glu Thr Lys Glu Gly Asp Val Thr Asp Glu His Gly 
        35                  40                  45              


Glu Arg Gly Ser Phe Ala Glu Thr Asp Glu His Thr Gly Val Asp Thr 
    50                  55                  60                  


Lys Glu Leu Glu Asp Ile Ala Ala Asp Ile Lys Glu His Leu Ala Ala 
65                  70                  75                  80  


Lys Arg Lys Arg Ile Glu Lys Ile Ala Lys Ala Cys Ser Glu Ile Lys 
                85                  90                  95      


Asn Arg Ile Lys Asn Val Leu Arg Thr Thr Gln Leu Lys Arg Gln Lys 
            100                 105                 110         


Arg Asp Tyr Arg Ile Ser Leu Lys Leu Pro Asn Val Leu Glu Glu Phe 
        115                 120                 125             


Ile Thr Asp Glu Gln Lys Asp Glu Glu Gly Asp Gly Glu Lys Glu Glu 
    130                 135                 140                 


Gln Ile Lys Ile Phe Gln Glu Gln Gln Lys Arg Trp Gln Gln Asp Gly 
145                 150                 155                 160 


Lys Gly Thr Glu Arg Asp 
                165     


<210>  6407
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  6407

Met Ser Ala Ile Phe Asn Phe Gln Ser Leu Leu Thr Val Ile Leu Leu 
1               5                   10                  15      


Leu Ile Cys Thr Cys Ala Tyr Ile Arg Ser Leu Ala Pro Ser Leu Leu 
            20                  25                  30          


Asp Arg Asn Lys Thr Gly Leu Leu Gly Ile Phe Trp Lys Cys Ala Arg 
        35                  40                  45              


Ile Gly Glu Arg Lys Ser Pro Tyr Val Ala Val Cys Cys Ile Val Met 
    50                  55                  60                  


Ala Phe Ser Ile Leu Phe Ile Gln 
65                  70          


<210>  6408
<211>  532
<212>  PRT
<213>  Homo sapiens

<400>  6408

Met Ala Pro Ser Phe Thr Ala Arg Ile Gln Leu Phe Leu Leu Arg Ala 
1               5                   10                  15      


Leu Gly Phe Leu Ile Gly Leu Val Gly Arg Ala Ala Leu Val Leu Gly 
            20                  25                  30          


Gly Pro Lys Phe Ala Ser Lys Thr Pro Arg Pro Val Thr Glu Pro Leu 
        35                  40                  45              


Leu Leu Leu Ser Gly Met Gln Leu Ala Lys Leu Ile Arg Gln Arg Lys 
    50                  55                  60                  


Val Lys Cys Ile Asp Val Val Gln Ala Tyr Ile Asn Arg Ile Lys Asp 
65                  70                  75                  80  


Val Asn Pro Met Ile Asn Gly Ile Val Lys Tyr Arg Phe Glu Glu Ala 
                85                  90                  95      


Met Lys Glu Ala His Ala Val Asp Gln Lys Leu Ala Glu Lys Gln Glu 
            100                 105                 110         


Asp Glu Ala Thr Leu Glu Asn Lys Trp Pro Phe Leu Gly Val Pro Leu 
        115                 120                 125             


Thr Val Lys Glu Ala Phe Gln Leu Gln Gly Met Pro Asn Ser Ser Gly 
    130                 135                 140                 


Leu Met Asn Arg Arg Asp Ala Ile Ala Lys Thr Asp Ala Thr Val Val 
145                 150                 155                 160 


Ala Leu Leu Lys Gly Ala Gly Ala Ile Pro Leu Gly Ile Thr Asn Cys 
                165                 170                 175     


Ser Glu Leu Cys Met Trp Tyr Glu Ser Ser Asn Lys Ile Tyr Gly Arg 
            180                 185                 190         


Ser Asn Asn Pro Tyr Asp Leu Gln His Ile Val Gly Gly Ser Ser Gly 
        195                 200                 205             


Gly Glu Gly Cys Thr Leu Ala Ala Ala Cys Ser Val Ile Gly Val Gly 
    210                 215                 220                 


Ser Asp Ile Gly Gly Ser Ile Arg Met Pro Ala Phe Phe Asn Gly Ile 
225                 230                 235                 240 


Phe Gly His Lys Pro Ser Pro Gly Val Val Pro Asn Lys Gly Gln Phe 
                245                 250                 255     


Pro Leu Ala Val Gly Ala Gln Glu Leu Phe Leu Cys Thr Gly Pro Met 
            260                 265                 270         


Cys Arg Tyr Ala Glu Asp Leu Ala Pro Met Leu Lys Val Met Ala Gly 
        275                 280                 285             


Pro Gly Ile Lys Arg Leu Lys Leu Asp Thr Lys Val His Leu Lys Asp 
    290                 295                 300                 


Leu Lys Phe Tyr Trp Met Glu His Asp Gly Gly Ser Phe Leu Met Ser 
305                 310                 315                 320 


Lys Val Asp Gln Asp Leu Ile Met Thr Gln Lys Lys Val Val Val His 
                325                 330                 335     


Leu Glu Thr Ile Leu Gly Ala Ser Val Gln His Val Lys Leu Lys Lys 
            340                 345                 350         


Met Lys Tyr Ser Phe Gln Leu Trp Ile Ala Met Met Ser Ala Lys Gly 
        355                 360                 365             


His Asp Gly Lys Glu Pro Val Lys Phe Val Asp Leu Leu Gly Asp His 
    370                 375                 380                 


Gly Lys His Val Ser Pro Leu Trp Glu Leu Ile Lys Trp Cys Leu Gly 
385                 390                 395                 400 


Leu Ser Val Tyr Thr Ile Pro Ser Ile Gly Leu Ala Leu Leu Glu Glu 
                405                 410                 415     


Lys Leu Arg Tyr Ser Asn Glu Lys Tyr Gln Lys Phe Lys Ala Val Glu 
            420                 425                 430         


Glu Ser Leu Arg Lys Glu Leu Val Asp Met Leu Gly Asp Asp Gly Val 
        435                 440                 445             


Phe Leu Tyr Pro Ser His Pro Thr Val Ala Pro Lys His His Val Pro 
    450                 455                 460                 


Leu Thr Arg Pro Phe Asn Phe Ala Tyr Thr Gly Val Phe Ser Ala Leu 
465                 470                 475                 480 


Gly Leu Pro Val Thr Gln Cys Pro Leu Gly Leu Asn Ala Lys Gly Leu 
                485                 490                 495     


Pro Leu Gly Ile Gln Val Val Ala Gly Pro Phe Asn Asp His Leu Thr 
            500                 505                 510         


Leu Ala Val Ala Gln Tyr Leu Glu Lys Thr Phe Gly Gly Trp Val Cys 
        515                 520                 525             


Pro Gly Lys Phe 
    530         


<210>  6409
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  6409

Met Glu Val Glu Glu Ile Tyr Lys His Gln Glu Val Lys Met Gln Ala 
1               5                   10                  15      


Pro Ala Phe Arg Asp Lys Lys Gln Gly Val Ser Ala Lys Asn Gln Gly 
            20                  25                  30          


Ala His Asp Pro Asp Tyr Glu Asn Ile Thr Leu Ala Phe Lys Asn Gln 
        35                  40                  45              


Asp His Ala Lys Gly Gly His Ser Arg Pro Thr Ser Gln Val Pro Ala 
    50                  55                  60                  


Gln Cys Arg Pro Pro Ser Asp Ser Thr Gln Val Pro Cys Trp Leu Tyr 
65                  70                  75                  80  


Arg Ala Ile Leu Ser Leu Tyr Ile Leu Leu Ala Leu Ala Phe Val Leu 
                85                  90                  95      


Cys Ile Ile Leu Ser Ala Phe Ile Met Val Lys Asn Ala Glu Met Ser 
            100                 105                 110         


Lys Glu Leu Leu Gly Phe Lys Arg Glu Leu Trp Asn Val Ser Asn Ser 
        115                 120                 125             


Val Gln Ala Cys Glu Glu Arg Gln Lys Arg Gly Trp Asp Ser Val Gln 
    130                 135                 140                 


Gln Ser Ile Thr Met Val Arg Ser Lys Ile Asp Arg Leu Glu Thr Thr 
145                 150                 155                 160 


Leu Ala Gly Ile Lys Asn Ile Asp Thr Lys Val Gln Lys Ile Leu Glu 
                165                 170                 175     


Val Leu Gln Lys Met Pro Gln Ser Ser Pro Gln 
            180                 185         


<210>  6410
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  6410

Met Ala Glu Gly Gly Phe Asp Pro Cys Glu Cys Val Cys Ser His Glu 
1               5                   10                  15      


His Ala Met Arg Arg Leu Ile Asn Leu Leu Arg Gln Ser Gln Ser Tyr 
            20                  25                  30          


Cys Thr Asp Thr Glu Cys Leu Gln Glu Leu Pro Gly Pro Ser Gly Asp 
        35                  40                  45              


Asn Gly Ile Ser Val Thr Met Ile Leu Val Ala Trp Met Val Ile Ala 
    50                  55                  60                  


Leu Ile Leu Phe Leu Leu Arg Pro Pro Asn Leu Arg Gly Ser Ser Leu 
65                  70                  75                  80  


Pro Gly Lys Pro Thr Ser Pro His Asn Gly Gln Asp Pro Pro Ala Pro 
                85                  90                  95      


Pro Val Asp 
            


<210>  6411
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  6411

Met Ala Gly Ala Val Ser Leu Leu Gly Val Val Gly Leu Leu Leu Val 
1               5                   10                  15      


Ser Ala Leu Ser Gly Val Leu Gly Asp Arg Ala Asn Pro Asp Leu Arg 
            20                  25                  30          


Ala His Pro Gly Asn Ala Ala His Pro Gly Ser Gly Ala Thr Glu Pro 
        35                  40                  45              


Arg Arg Arg Pro Pro Leu Lys Asp Gln Arg Glu Arg Thr Arg Ala Gly 
    50                  55                  60                  


Ser Leu Pro Leu Gly Ala Leu Tyr Thr Ala Ala Val Ala Ala Phe Val 
65                  70                  75                  80  


Leu Tyr Lys Cys Leu Gln Gly Lys Asp Glu Thr Ala Val Leu His Glu 
                85                  90                  95      


Glu Ala Ser Lys Gln Gln Pro Leu Gln Ser Glu Gln Gln Leu Ala Gln 
            100                 105                 110         


Leu Thr Gln Gln Leu Ala Gln Thr Glu Gln His Leu Asn Asn Leu Met 
        115                 120                 125             


Ala Gln Leu Asp Pro Leu Phe Glu Arg Val Thr Thr Leu Ala Gly Ala 
    130                 135                 140                 


Gln Gln Glu Leu Leu Asn Met Lys Leu Trp Thr Ile His Glu Leu Leu 
145                 150                 155                 160 


Gln Asp Ser Lys Pro Asp Lys Asp Met Glu Ala Ser Glu Pro Gly Glu 
                165                 170                 175     


Gly Ser Gly Gly Glu Ser Ala Gly Gly Gly Asp Lys Val Ser Glu Thr 
            180                 185                 190         


Gly Thr Phe Leu Ile Ser Pro His Thr Glu Ala Ser Arg Pro Leu Pro 
        195                 200                 205             


Glu Asp Phe Cys Leu Lys Glu Asp Glu Glu Glu Ile Gly Asp Ser Gln 
    210                 215                 220                 


Ala Trp Glu Glu Pro Thr Asn Trp Ser Thr Glu Thr Trp Asn Leu Ala 
225                 230                 235                 240 


Thr Ser Trp Glu Val Gly Arg Gly Leu Arg Arg Arg Cys Ser Gln Ala 
                245                 250                 255     


Val Ala Lys Gly Pro Ser His Ser Leu Gly Trp Glu Gly Gly Thr Thr 
            260                 265                 270         


Ala Glu Gly Arg Leu Lys Gln Ser Leu Phe Ser 
        275                 280             


<210>  6412
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  6412

Met Thr Gln Cys Cys Phe Leu Arg Val His Pro Leu Phe Phe Trp Phe 
1               5                   10                  15      


Trp Ser Phe His His Arg Met Ala Leu Ala Leu Cys Leu Gln Val Leu 
            20                  25                  30          


Cys Ser Leu Cys Gly Trp Leu Ser Leu Tyr Ile Ser Phe Cys His Leu 
        35                  40                  45              


Asn Lys His Arg Ser Tyr Glu Trp Ser Cys Arg Leu Val Thr Phe Thr 
    50                  55                  60                  


His Gly Val Leu Ser Ile Gly Leu Ser Ala Tyr Ile Gly Phe Ile Asp 
65                  70                  75                  80  


Gly Pro Trp Pro Phe Thr His Pro Gly Ser Pro Asn Thr Pro Leu Gln 
                85                  90                  95      


Val His Val Leu Cys Leu Thr Leu Gly Tyr Phe Ile Phe Asp Leu Gly 
            100                 105                 110         


Cys Ile Trp Arg Phe Ala Trp Arg Lys Ser Ile Lys Lys Tyr His Ala 
        115                 120                 125             


Trp Arg Ser Arg Arg Ser Glu Glu Arg Gln Leu Lys His Asn Gly His 
    130                 135                 140                 


Leu Lys Ile His 
145             


<210>  6413
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  6413

Met Pro Gly Ala Gly Asp Gly Gly Lys Ala Pro Ala Arg Trp Leu Gly 
1               5                   10                  15      


Thr Gly Leu Leu Gly Leu Phe Leu Leu Pro Val Thr Leu Ser Leu Glu 
            20                  25                  30          


Val Ser Val Gly Lys Ala Thr Asp Ile Tyr Ala Val Asn Gly Thr Glu 
        35                  40                  45              


Ile Leu Leu Pro Cys Thr Phe Ser Ser Cys Phe Gly Phe Glu Asp Leu 
    50                  55                  60                  


His Phe Arg Trp Thr Tyr Asn Ser Ser Asp Ala Phe Lys Ile Leu Ile 
65                  70                  75                  80  


Glu Gly Thr Val Lys Asn Glu Lys Ser Asp Pro Lys Val Thr Leu Lys 
                85                  90                  95      


Asp Asp Asp Arg Ile Thr Leu Val Gly Ser Thr Lys Glu Lys Met Asn 
            100                 105                 110         


Asn Ile Ser Ile Val Leu Arg Asp Leu Glu Phe Ser Asp Thr Gly Lys 
        115                 120                 125             


Tyr Thr Cys His Val Lys Asn Pro Lys Glu Asn Asn Leu Gln His His 
    130                 135                 140                 


Ala Thr Ile Phe Leu Gln Val Val Asp Arg Leu Glu Glu Val Asp Asn 
145                 150                 155                 160 


Thr Val Thr Leu Ile Ile Leu Ala Val Val Gly Gly Val Ile Gly Leu 
                165                 170                 175     


Leu Ile Leu Ile Leu Leu Ile Lys Lys Leu Ile Ile Phe Ile Leu Lys 
            180                 185                 190         


Lys Thr Arg Glu Lys Lys Lys Glu Cys Leu Val Ser Ser Ser Gly Asn 
        195                 200                 205             


Asp Asn Thr Glu Asn Gly Leu Pro Gly Ser Lys Ala Glu Glu Lys Pro 
    210                 215                 220                 


Pro Ser Lys Val 
225             


<210>  6414
<211>  597
<212>  PRT
<213>  Homo sapiens

<400>  6414

Met Phe Ala Ser Cys His Cys Val Pro Arg Gly Arg Arg Thr Met Lys 
1               5                   10                  15      


Met Ile His Phe Arg Ser Ser Ser Val Lys Ser Leu Ser Gln Glu Met 
            20                  25                  30          


Arg Cys Thr Ile Arg Leu Leu Asp Asp Ser Glu Ile Ser Cys His Ile 
        35                  40                  45              


Gln Arg Glu Thr Lys Gly Gln Phe Leu Ile Asp His Ile Cys Asn Tyr 
    50                  55                  60                  


Tyr Ser Leu Leu Glu Lys Asp Tyr Phe Gly Ile Arg Tyr Val Asp Pro 
65                  70                  75                  80  


Glu Lys Gln Arg His Trp Leu Glu Pro Asn Lys Ser Ile Phe Lys Gln 
                85                  90                  95      


Met Lys Thr His Pro Pro Tyr Thr Met Cys Phe Arg Val Lys Phe Tyr 
            100                 105                 110         


Pro His Glu Pro Leu Lys Ile Lys Glu Glu Leu Thr Arg Tyr Leu Leu 
        115                 120                 125             


Tyr Leu Gln Ile Lys Arg Asp Ile Phe His Gly Arg Leu Leu Cys Ser 
    130                 135                 140                 


Phe Ser Asp Ala Ala Tyr Leu Gly Ala Cys Ile Val Gln Ala Glu Leu 
145                 150                 155                 160 


Gly Asp Tyr Asp Pro Asp Glu His Pro Glu Asn Tyr Ile Ser Glu Phe 
                165                 170                 175     


Glu Ile Phe Pro Lys Gln Ser Gln Lys Leu Glu Arg Lys Ile Val Glu 
            180                 185                 190         


Ile His Lys Asn Glu Leu Arg Gly Gln Ser Pro Pro Val Ala Glu Phe 
        195                 200                 205             


Asn Leu Leu Leu Lys Ala His Thr Leu Glu Thr Tyr Gly Val Asp Pro 
    210                 215                 220                 


His Pro Cys Lys Asp Ser Thr Gly Thr Thr Thr Phe Leu Gly Phe Thr 
225                 230                 235                 240 


Ala Ala Gly Phe Val Val Phe Gln Gly Asn Lys Arg Ile His Leu Ile 
                245                 250                 255     


Lys Trp Pro Asp Val Cys Lys Leu Lys Phe Glu Gly Lys Thr Phe Tyr 
            260                 265                 270         


Val Ile Gly Thr Gln Lys Glu Lys Lys Ala Met Leu Ala Phe His Thr 
        275                 280                 285             


Ser Thr Pro Ala Ala Cys Lys His Leu Trp Lys Cys Gly Val Glu Asn 
    290                 295                 300                 


Gln Ala Phe Tyr Lys Tyr Ala Lys Ser Ser Gln Ile Lys Thr Val Ser 
305                 310                 315                 320 


Ser Ser Lys Ile Phe Phe Lys Gly Ser Arg Phe Arg Tyr Ser Gly Lys 
                325                 330                 335     


Val Ala Lys Glu Val Val Glu Ala Ser Ser Lys Ile Gln Arg Glu Pro 
            340                 345                 350         


Pro Glu Val His Arg Ala Asn Ile Thr Gln Ser Arg Ser Ser His Ser 
        355                 360                 365             


Leu Asn Lys Gln Leu Ile Ile Asn Met Glu Pro Leu Gln Pro Leu Leu 
    370                 375                 380                 


Pro Ser Pro Ser Glu Gln Glu Glu Glu Leu Pro Leu Gly Glu Gly Val 
385                 390                 395                 400 


Pro Leu Pro Lys Glu Glu Asn Ile Ser Ala Pro Leu Ile Ser Ser Ser 
                405                 410                 415     


Pro Val Lys Ala Ala Arg Glu Tyr Glu Asp Pro Pro Ser Glu Glu Glu 
            420                 425                 430         


Asp Lys Ile Lys Glu Glu Pro Leu Thr Ile Ser Glu Leu Val Tyr Asn 
        435                 440                 445             


Pro Ser Ala Ser Leu Leu Pro Thr Pro Val Asp Asp Asp Glu Ile Asp 
    450                 455                 460                 


Met Leu Phe Asp Cys Pro Ser Arg Leu Glu Leu Glu Arg Glu Asp Thr 
465                 470                 475                 480 


Asp Ser Phe Glu Asp Leu Glu Ala Asp Glu Asn Ala Phe Leu Ile Ala 
                485                 490                 495     


Glu Glu Glu Glu Leu Lys Glu Ala Arg Arg Ala Leu Ser Trp Ser Tyr 
            500                 505                 510         


Asp Ile Leu Thr Gly His Ile Arg Val Asn Pro Leu Val Lys Ser Phe 
        515                 520                 525             


Ser Arg Leu Leu Val Val Gly Leu Gly Leu Leu Leu Phe Val Phe Pro 
    530                 535                 540                 


Leu Leu Leu Leu Leu Leu Glu Ser Gly Ile Asp Leu Ser Phe Leu Cys 
545                 550                 555                 560 


Glu Ile Arg Gln Thr Pro Glu Phe Glu Gln Phe His Tyr Glu Tyr Tyr 
                565                 570                 575     


Cys Pro Leu Lys Glu Trp Val Ala Gly Lys Val His Leu Ile Leu Tyr 
            580                 585                 590         


Met Leu Gly Cys Ser 
        595         


<210>  6415
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  6415

Met Leu Pro Asn Val Gly Ser Pro Pro Leu Pro Phe Arg Lys Cys Pro 
1               5                   10                  15      


Ser Gly Ala Gly Arg Thr Asn Arg Ala Ser Ala Val Ala Arg Thr Ser 
            20                  25                  30          


Ala Pro Glu Thr Arg Arg Gly Arg Ala Pro Ser Ser Gly Asp Ala Lys 
        35                  40                  45              


Met Ala Glu Gly Ala Arg Ala Arg Gly Pro Arg Gly Cys Arg Asp Arg 
    50                  55                  60                  


Asp Gly Pro Ala Gly Gly Ala Gly Arg Gly Ser Ser Thr Val Leu Ser 
65                  70                  75                  80  


Ser Val Pro Leu Gln Met Leu Phe Tyr Leu Ser Gly Thr Tyr Tyr Ala 
                85                  90                  95      


Leu Tyr Phe Leu Ala Thr Leu Leu Met Ile Thr Tyr Lys Ser Gln Val 
            100                 105                 110         


Phe Ser Tyr Pro His Arg Tyr Leu Val Leu Asp Leu Ala Leu Leu Phe 
        115                 120                 125             


Leu Met Gly Ile Leu Glu Ala Val Arg Leu Tyr Leu Gly Thr Arg Gly 
    130                 135                 140                 


Asn Leu Thr Glu Ala Glu Arg Pro Leu Ala Ala Ser Leu Ala Leu Thr 
145                 150                 155                 160 


Ala Gly Thr Ala Leu Leu Ser Ala His Phe Leu Leu Trp Gln Ala Leu 
                165                 170                 175     


Val Leu Trp Ala Asp Trp Ala Leu Ser Ala Thr Leu Leu Ala Leu His 
            180                 185                 190         


Gly Leu Glu Ala Val Leu Gln Val Val Ala Ile Ala Ala Phe Thr Arg 
        195                 200                 205             


<210>  6416
<211>  1453
<212>  PRT
<213>  Homo sapiens

<400>  6416

Met Met Leu Pro Gln Asn Ser Trp His Ile Asp Phe Gly Arg Cys Cys 
1               5                   10                  15      


Cys His Gln Asn Leu Phe Ser Ala Val Val Thr Cys Ile Leu Leu Leu 
            20                  25                  30          


Asn Ser Cys Phe Leu Ile Ser Ser Phe Asn Gly Thr Asp Leu Glu Leu 
        35                  40                  45              


Arg Leu Val Asn Gly Asp Gly Pro Cys Ser Gly Thr Val Glu Val Lys 
    50                  55                  60                  


Phe Gln Gly Gln Trp Gly Thr Val Cys Asp Asp Gly Trp Asn Thr Thr 
65                  70                  75                  80  


Ala Ser Thr Val Val Cys Lys Gln Leu Gly Cys Pro Phe Ser Phe Ala 
                85                  90                  95      


Met Phe Arg Phe Gly Gln Ala Val Thr Arg His Gly Lys Ile Trp Leu 
            100                 105                 110         


Asp Asp Val Ser Cys Tyr Gly Asn Glu Ser Ala Leu Trp Glu Cys Gln 
        115                 120                 125             


His Arg Glu Trp Gly Ser His Asn Cys Tyr His Gly Glu Asp Val Gly 
    130                 135                 140                 


Val Asn Cys Tyr Gly Glu Ala Asn Leu Gly Leu Arg Leu Val Asp Gly 
145                 150                 155                 160 


Asn Asn Ser Cys Ser Gly Arg Val Glu Val Lys Phe Gln Glu Arg Trp 
                165                 170                 175     


Gly Thr Ile Cys Asp Asp Gly Trp Asn Leu Asn Thr Ala Ala Val Val 
            180                 185                 190         


Cys Arg Gln Leu Gly Cys Pro Ser Ser Phe Ile Ser Ser Gly Val Val 
        195                 200                 205             


Asn Ser Pro Ala Val Leu Arg Pro Ile Trp Leu Asp Asp Ile Leu Cys 
    210                 215                 220                 


Gln Gly Asn Glu Leu Ala Leu Trp Asn Cys Arg His Arg Gly Trp Gly 
225                 230                 235                 240 


Asn His Asp Cys Ser His Asn Glu Asp Val Thr Leu Thr Cys Tyr Asp 
                245                 250                 255     


Ser Ser Asp Leu Glu Leu Arg Leu Val Gly Gly Thr Asn Arg Cys Met 
            260                 265                 270         


Gly Arg Val Glu Leu Lys Ile Gln Gly Arg Trp Gly Thr Val Cys His 
        275                 280                 285             


His Lys Trp Asn Asn Ala Ala Ala Asp Val Val Cys Lys Gln Leu Gly 
    290                 295                 300                 


Cys Gly Thr Ala Leu His Phe Ala Gly Leu Pro His Leu Gln Ser Gly 
305                 310                 315                 320 


Ser Asp Val Val Trp Leu Asp Gly Val Ser Cys Ser Gly Asn Glu Ser 
                325                 330                 335     


Phe Leu Trp Asp Cys Arg His Ser Gly Thr Val Asn Phe Asp Cys Leu 
            340                 345                 350         


His Gln Asn Asp Val Ser Val Ile Cys Ser Asp Gly Ala Asp Leu Glu 
        355                 360                 365             


Leu Arg Leu Ala Asp Gly Ser Asn Asn Cys Ser Gly Arg Val Glu Val 
    370                 375                 380                 


Arg Ile His Glu Gln Trp Trp Thr Ile Cys Asp Gln Asn Trp Lys Asn 
385                 390                 395                 400 


Glu Gln Ala Leu Val Val Cys Lys Gln Leu Gly Cys Pro Phe Ser Val 
                405                 410                 415     


Phe Gly Ser Arg Arg Ala Lys Pro Ser Asn Glu Ala Arg Asp Ile Trp 
            420                 425                 430         


Ile Asn Ser Ile Ser Cys Thr Gly Asn Glu Ser Ala Leu Trp Asp Cys 
        435                 440                 445             


Thr Tyr Asp Gly Lys Ala Lys Arg Thr Cys Phe Arg Arg Ser Asp Ala 
    450                 455                 460                 


Gly Val Ile Cys Ser Asp Lys Ala Asp Leu Asp Leu Arg Leu Val Gly 
465                 470                 475                 480 


Ala His Ser Pro Cys Tyr Gly Arg Leu Glu Val Lys Tyr Gln Gly Glu 
                485                 490                 495     


Trp Gly Thr Val Cys His Asp Arg Trp Ser Thr Arg Asn Ala Ala Val 
            500                 505                 510         


Val Cys Lys Gln Leu Gly Cys Gly Lys Pro Met His Val Phe Gly Met 
        515                 520                 525             


Thr Tyr Phe Lys Glu Ala Ser Gly Pro Ile Trp Leu Asp Asp Val Ser 
    530                 535                 540                 


Cys Ile Gly Asn Glu Ser Asn Ile Trp Asp Cys Glu His Ser Gly Trp 
545                 550                 555                 560 


Gly Lys His Asn Cys Val His Arg Glu Asp Val Ile Val Thr Cys Ser 
                565                 570                 575     


Gly Asp Ala Thr Trp Gly Leu Arg Leu Val Gly Gly Ser Asn Arg Cys 
            580                 585                 590         


Ser Gly Arg Leu Glu Val Tyr Phe Gln Gly Arg Trp Gly Thr Val Cys 
        595                 600                 605             


Asp Asp Gly Trp Asn Ser Lys Ala Ala Ala Val Val Cys Ser Gln Leu 
    610                 615                 620                 


Asp Cys Pro Ser Ser Ile Ile Gly Met Gly Leu Gly Asn Ala Ser Thr 
625                 630                 635                 640 


Gly Tyr Gly Lys Ile Trp Leu Asp Asp Val Ser Cys Asp Gly Asp Glu 
                645                 650                 655     


Ser Asp Leu Trp Ser Cys Arg Asn Ser Gly Trp Gly Asn Asn Asp Cys 
            660                 665                 670         


Ser His Ser Glu Asp Val Gly Val Ile Cys Ser Asp Ala Ser Asp Met 
        675                 680                 685             


Glu Leu Arg Leu Val Gly Gly Ser Ser Arg Cys Ala Gly Lys Val Glu 
    690                 695                 700                 


Val Asn Val Gln Gly Ala Val Gly Ile Leu Cys Ala Asn Gly Trp Gly 
705                 710                 715                 720 


Met Asn Ile Ala Glu Val Val Cys Arg Gln Leu Glu Cys Gly Ser Ala 
                725                 730                 735     


Ile Arg Val Ser Arg Glu Pro His Phe Thr Glu Arg Thr Leu His Ile 
            740                 745                 750         


Leu Met Ser Asn Ser Gly Cys Thr Gly Gly Glu Ala Ser Leu Trp Asp 
        755                 760                 765             


Cys Ile Arg Trp Glu Trp Lys Gln Thr Ala Cys His Leu Asn Met Glu 
    770                 775                 780                 


Ala Ser Leu Ile Cys Ser Ala His Arg Gln Pro Arg Leu Val Gly Ala 
785                 790                 795                 800 


Asp Met Pro Cys Ser Gly Arg Val Glu Val Lys His Ala Asp Thr Trp 
                805                 810                 815     


Arg Ser Val Cys Asp Ser Asp Phe Ser Leu His Ala Ala Asn Val Leu 
            820                 825                 830         


Cys Arg Glu Leu Asn Cys Gly Asp Ala Ile Ser Leu Ser Val Gly Asp 
        835                 840                 845             


His Phe Gly Lys Gly Asn Gly Leu Thr Trp Ala Glu Lys Phe Gln Cys 
    850                 855                 860                 


Glu Gly Ser Glu Thr His Leu Ala Leu Cys Pro Ile Val Gln His Pro 
865                 870                 875                 880 


Glu Asp Thr Cys Ile His Ser Arg Glu Val Gly Val Val Cys Ser Arg 
                885                 890                 895     


Tyr Thr Asp Val Arg Leu Val Asn Gly Lys Ser Gln Cys Asp Gly Gln 
            900                 905                 910         


Val Glu Ile Asn Val Leu Gly His Trp Gly Ser Leu Cys Asp Thr His 
        915                 920                 925             


Trp Asp Pro Glu Asp Ala Arg Val Leu Cys Arg Gln Leu Ser Cys Gly 
    930                 935                 940                 


Thr Ala Leu Ser Thr Thr Gly Gly Lys Tyr Ile Gly Glu Arg Ser Val 
945                 950                 955                 960 


Arg Val Trp Gly His Arg Phe His Cys Leu Gly Asn Glu Ser Leu Leu 
                965                 970                 975     


Asp Asn Cys Gln Met Thr Val Leu Gly Ala Pro Pro Cys Ile His Gly 
            980                 985                 990         


Asn Thr Val Ser Val Ile Cys Thr  Gly Ser Leu Thr Gln  Pro Leu Phe 
        995                 1000                 1005             


Pro Cys  Leu Ala Asn Val Ser  Asp Pro Tyr Leu Ser  Ala Val Pro 
    1010                 1015                 1020             


Glu Gly  Ser Ala Leu Ile Cys  Leu Glu Asp Lys Arg  Leu Arg Leu 
    1025                 1030                 1035             


Val Asp  Gly Asp Ser Arg Cys  Ala Gly Arg Val Glu  Ile Tyr His 
    1040                 1045                 1050             


Asp Gly  Phe Trp Gly Thr Ile  Cys Asp Asp Gly Trp  Asp Leu Ser 
    1055                 1060                 1065             


Asp Ala  His Val Val Cys Gln  Lys Leu Gly Cys Gly  Val Ala Phe 
    1070                 1075                 1080             


Asn Ala  Thr Val Ser Ala His  Phe Gly Glu Gly Ser  Gly Pro Ile 
    1085                 1090                 1095             


Trp Leu  Asp Asp Leu Asn Cys  Thr Gly Met Glu Ser  His Leu Trp 
    1100                 1105                 1110             


Gln Cys  Pro Ser Arg Gly Trp  Gly Gln His Asp Cys  Arg His Lys 
    1115                 1120                 1125             


Glu Asp  Ala Gly Val Ile Cys  Ser Glu Phe Thr Ala  Leu Arg Leu 
    1130                 1135                 1140             


Tyr Ser  Glu Thr Glu Thr Glu  Ser Cys Ala Gly Arg  Leu Glu Val 
    1145                 1150                 1155             


Phe Tyr  Asn Gly Thr Trp Gly  Ser Val Gly Arg Arg  Asn Ile Thr 
    1160                 1165                 1170             


Thr Ala  Ile Ala Gly Ile Val  Cys Arg Gln Leu Gly  Cys Gly Glu 
    1175                 1180                 1185             


Asn Gly  Val Val Ser Leu Ala  Pro Leu Ser Lys Thr  Gly Ser Gly 
    1190                 1195                 1200             


Phe Met  Trp Val Asp Asp Ile  Gln Cys Pro Lys Thr  His Ile Ser 
    1205                 1210                 1215             


Ile Trp  Gln Cys Leu Ser Ala  Pro Trp Glu Arg Arg  Ile Ser Ser 
    1220                 1225                 1230             


Pro Ala  Glu Glu Thr Trp Ile  Thr Cys Glu Asp Arg  Ile Arg Val 
    1235                 1240                 1245             


Arg Gly  Gly Asp Thr Glu Cys  Ser Gly Arg Val Glu  Ile Trp His 
    1250                 1255                 1260             


Ala Gly  Ser Trp Gly Thr Val  Cys Asp Asp Ser Trp  Asp Leu Ala 
    1265                 1270                 1275             


Glu Ala  Glu Val Val Cys Gln  Gln Leu Gly Cys Gly  Ser Ala Leu 
    1280                 1285                 1290             


Ala Ala  Leu Arg Asp Ala Ser  Phe Gly Gln Gly Thr  Gly Thr Ile 
    1295                 1300                 1305             


Trp Leu  Asp Asp Met Arg Cys  Lys Gly Asn Glu Ser  Phe Leu Trp 
    1310                 1315                 1320             


Asp Cys  His Ala Lys Pro Trp  Gly Gln Ser Asp Cys  Gly His Lys 
    1325                 1330                 1335             


Glu Asp  Ala Gly Val Arg Cys  Ser Gly Gln Ser Leu  Lys Ser Leu 
    1340                 1345                 1350             


Asn Ala  Ser Ser Gly His Leu  Ala Leu Ile Leu Ser  Ser Ile Phe 
    1355                 1360                 1365             


Gly Leu  Leu Leu Leu Val Leu  Phe Ile Leu Phe Leu  Thr Trp Cys 
    1370                 1375                 1380             


Arg Val  Gln Lys Gln Lys His  Leu Pro Leu Arg Val  Ser Thr Arg 
    1385                 1390                 1395             


Arg Arg  Gly Ser Leu Glu Glu  Asn Leu Phe His Glu  Met Glu Thr 
    1400                 1405                 1410             


Cys Leu  Lys Arg Glu Asp Pro  His Gly Thr Arg Thr  Ser Asp Asp 
    1415                 1420                 1425             


Thr Pro  Asn His Gly Cys Glu  Asp Ala Ser Asp Thr  Ser Leu Leu 
    1430                 1435                 1440             


Gly Val  Leu Pro Ala Ser Glu  Ala Thr Lys 
    1445                 1450             


<210>  6417
<211>  1052
<212>  PRT
<213>  Homo sapiens

<400>  6417

Met Glu Ala Ala His Leu Leu Pro Ala Ala Asp Val Leu Arg His Phe 
1               5                   10                  15      


Ser Val Thr Ala Glu Gly Gly Leu Ser Pro Ala Gln Val Thr Gly Ala 
            20                  25                  30          


Arg Glu Arg Tyr Gly Pro Asn Glu Leu Pro Ser Glu Glu Gly Lys Ser 
        35                  40                  45              


Leu Trp Glu Leu Val Leu Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Leu Val Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Thr Thr Ala Phe Val Glu Pro Leu Val Ile Met Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Ser Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Ile Arg Ser Asp Arg Lys Gly Val Gln Arg Ile Arg Ala Arg Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Leu Arg Leu Ile Glu Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Thr Lys His Thr Glu 
            180                 185                 190         


Ala Ile Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Thr Ser Gly Lys Ala Val Gly Val Ala Val 
    210                 215                 220                 


Ala Thr Gly Leu His Thr Glu Leu Gly Lys Ile Arg Ser Gln Met Ala 
225                 230                 235                 240 


Ala Val Glu Pro Glu Arg Thr Pro Leu Gln Arg Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Arg Gln Leu Ser His Ala Ile Ser Val Ile Cys Val Ala Val Trp 
            260                 265                 270         


Val Ile Asn Ile Gly His Phe Ala Asp Pro Ala His Gly Gly Ser Trp 
        275                 280                 285             


Leu Arg Gly Ala Val Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Arg Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Val 
        355                 360                 365             


Val Ala Glu Ala Asp Ala Gly Ser Cys Leu Leu His Glu Phe Thr Ile 
    370                 375                 380                 


Ser Gly Thr Thr Tyr Thr Pro Glu Gly Glu Val Arg Gln Gly Asp Gln 
385                 390                 395                 400 


Pro Val Arg Cys Gly Gln Phe Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Asp Leu Gln Ala Leu Ser Arg 
    450                 455                 460                 


Val Glu Arg Ala Gly Ala Cys Asn Thr Val Ile Lys Gln Leu Met Arg 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Thr Arg Pro His Pro Thr Gly Gln Gly Ser Lys Met 
            500                 505                 510         


Phe Val Lys Gly Ala Pro Glu Ser Val Ile Glu Arg Cys Ser Ser Val 
        515                 520                 525             


Arg Val Gly Ser Arg Thr Ala Pro Leu Thr Pro Thr Ser Arg Glu Gln 
    530                 535                 540                 


Ile Leu Ala Lys Ile Arg Asp Trp Gly Ser Gly Ser Asp Thr Leu Arg 
545                 550                 555                 560 


Cys Leu Ala Leu Ala Thr Arg Asp Ala Pro Pro Arg Lys Glu Asp Met 
                565                 570                 575     


Glu Leu Asp Asp Cys Ser Lys Phe Val Gln Tyr Glu Thr Asp Leu Thr 
            580                 585                 590         


Phe Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Pro Glu Val Ala 
        595                 600                 605             


Ala Cys Ile Thr Arg Cys Tyr Gln Ala Gly Ile Arg Val Val Met Ile 
    610                 615                 620                 


Thr Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Leu Gly 
625                 630                 635                 640 


Ile Phe Gly Asp Thr Glu Asp Val Ala Gly Lys Ala Tyr Thr Gly Arg 
                645                 650                 655     


Glu Phe Asp Asp Leu Ser Pro Glu Gln Gln Arg Gln Ala Cys Arg Thr 
            660                 665                 670         


Ala Arg Cys Phe Ala Arg Val Glu Pro Ala His Lys Ser Arg Ile Val 
        675                 680                 685             


Glu Asn Leu Gln Ser Phe Asn Glu Ile Thr Ala Met Thr Gly Asp Gly 
    690                 695                 700                 


Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met 
705                 710                 715                 720 


Gly Ser Gly Thr Ala Val Ala Lys Ser Ala Ala Glu Met Val Leu Ser 
                725                 730                 735     


Asp Asp Asn Phe Ala Ser Ile Val Ala Ala Val Glu Glu Gly Arg Ala 
            740                 745                 750         


Ile Tyr Ser Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn 
        755                 760                 765             


Val Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ile Leu Gly Leu Pro 
    770                 775                 780                 


Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp 
785                 790                 795                 800 


Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile 
                805                 810                 815     


Met Glu Lys Leu Pro Arg Ser Pro Arg Glu Ala Leu Ile Ser Gly Trp 
            820                 825                 830         


Leu Phe Phe Arg Tyr Leu Ala Ile Gly Val Tyr Val Gly Leu Ala Thr 
        835                 840                 845             


Val Ala Ala Ala Thr Trp Trp Phe Val Tyr Asp Ala Glu Gly Pro His 
    850                 855                 860                 


Ile Asn Phe Tyr Gln Leu Arg Asn Phe Leu Lys Cys Ser Glu Asp Asn 
865                 870                 875                 880 


Pro Leu Phe Ala Gly Ile Asp Cys Glu Val Phe Glu Ser Arg Phe Pro 
                885                 890                 895     


Thr Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala 
            900                 905                 910         


Leu Asn Ser Val Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp 
        915                 920                 925             


Met Asn Pro Trp Leu Leu Val Ala Val Ala Met Ser Met Ala Leu His 
    930                 935                 940                 


Phe Leu Ile Leu Leu Val Pro Pro Leu Pro Leu Ile Phe Gln Val Thr 
945                 950                 955                 960 


Pro Leu Ser Gly Arg Gln Trp Val Val Val Leu Gln Ile Ser Leu Pro 
                965                 970                 975     


Val Ile Leu Leu Asp Glu Ala Leu Lys Tyr Leu Ser Arg Asn His Met 
            980                 985                 990         


His Ala Cys Leu Tyr Pro Gly Leu  Leu Arg Thr Val Ser  Gln Ala Trp 
        995                 1000                 1005             


Ser Arg  Gln Pro Leu Thr Thr  Ser Trp Thr Pro Asp  His Thr Gly 
    1010                 1015                 1020             


Leu Ala  Ser Leu Gly Gln Gly  His Ser Ile Val Ser  Leu Ser Glu 
    1025                 1030                 1035             


Leu Leu  Arg Glu Gly Gly Ser  Arg Glu Glu Met Ser  Gln Lys 
    1040                 1045                 1050         


<210>  6418
<211>  1044
<212>  PRT
<213>  Homo sapiens

<400>  6418

Met Glu Ala Ala His Leu Leu Pro Ala Ala Asp Val Leu Arg His Phe 
1               5                   10                  15      


Ser Val Thr Ala Glu Gly Gly Leu Ser Pro Ala Gln Val Thr Gly Ala 
            20                  25                  30          


Arg Glu Arg Tyr Gly Pro Asn Glu Leu Pro Ser Glu Glu Gly Lys Ser 
        35                  40                  45              


Leu Trp Glu Leu Val Leu Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Leu Val Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Thr Thr Ala Phe Val Glu Pro Leu Val Ile Met Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Ser Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Ile Arg Ser Asp Arg Lys Gly Val Gln Arg Ile Arg Ala Arg Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Leu Arg Leu Ile Glu Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Thr Lys His Thr Glu 
            180                 185                 190         


Ala Ile Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Thr Ser Gly Lys Ala Val Gly Val Ala Val 
    210                 215                 220                 


Ala Thr Gly Leu His Thr Glu Leu Gly Lys Ile Arg Ser Gln Met Ala 
225                 230                 235                 240 


Ala Val Glu Pro Glu Arg Thr Pro Leu Gln Arg Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Arg Gln Leu Ser His Ala Ile Ser Val Ile Cys Val Ala Val Trp 
            260                 265                 270         


Val Ile Asn Ile Gly His Phe Ala Asp Pro Ala His Gly Gly Ser Trp 
        275                 280                 285             


Leu Arg Gly Ala Val Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Arg Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Val 
        355                 360                 365             


Val Ala Glu Ala Asp Ala Gly Ser Cys Leu Leu His Glu Phe Thr Ile 
    370                 375                 380                 


Ser Gly Thr Thr Tyr Thr Pro Glu Gly Glu Val Arg Gln Gly Asp Gln 
385                 390                 395                 400 


Pro Val Arg Cys Gly Gln Phe Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Asp Leu Gln Ala Leu Ser Arg 
    450                 455                 460                 


Val Glu Arg Ala Gly Ala Cys Asn Thr Val Ile Lys Gln Leu Met Arg 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Thr Arg Pro His Pro Thr Gly Gln Gly Ser Lys Met 
            500                 505                 510         


Phe Val Lys Gly Ala Pro Glu Ser Val Ile Glu Arg Cys Ser Ser Val 
        515                 520                 525             


Arg Val Gly Ser Arg Thr Ala Pro Leu Thr Pro Thr Ser Arg Glu Gln 
    530                 535                 540                 


Ile Leu Ala Lys Ile Arg Asp Trp Gly Ser Gly Ser Asp Thr Leu Arg 
545                 550                 555                 560 


Cys Leu Ala Leu Ala Thr Arg Asp Ala Pro Pro Arg Lys Glu Asp Met 
                565                 570                 575     


Glu Leu Asp Asp Cys Ser Lys Phe Val Gln Tyr Glu Thr Asp Leu Thr 
            580                 585                 590         


Phe Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Pro Glu Val Ala 
        595                 600                 605             


Ala Cys Ile Thr Arg Cys Tyr Gln Ala Gly Ile Arg Val Val Met Ile 
    610                 615                 620                 


Thr Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Leu Gly 
625                 630                 635                 640 


Ile Phe Gly Asp Thr Glu Asp Val Ala Gly Lys Ala Tyr Thr Gly Arg 
                645                 650                 655     


Glu Phe Asp Asp Leu Ser Pro Glu Gln Gln Arg Gln Ala Cys Arg Thr 
            660                 665                 670         


Ala Arg Cys Phe Ala Arg Val Glu Pro Ala His Lys Ser Arg Ile Val 
        675                 680                 685             


Glu Asn Leu Gln Ser Phe Asn Glu Ile Thr Ala Met Thr Gly Asp Gly 
    690                 695                 700                 


Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met 
705                 710                 715                 720 


Gly Ser Gly Thr Ala Val Ala Lys Ser Ala Ala Glu Met Val Leu Ser 
                725                 730                 735     


Asp Asp Asn Phe Ala Ser Ile Val Ala Ala Val Glu Glu Gly Arg Ala 
            740                 745                 750         


Ile Tyr Ser Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn 
        755                 760                 765             


Val Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ile Leu Gly Leu Pro 
    770                 775                 780                 


Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp 
785                 790                 795                 800 


Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile 
                805                 810                 815     


Met Glu Lys Leu Pro Arg Ser Pro Arg Glu Ala Leu Ile Ser Gly Trp 
            820                 825                 830         


Leu Phe Phe Arg Tyr Leu Ala Ile Gly Val Tyr Val Gly Leu Ala Thr 
        835                 840                 845             


Val Ala Ala Ala Thr Trp Trp Phe Val Tyr Asp Ala Glu Gly Pro His 
    850                 855                 860                 


Ile Asn Phe Tyr Gln Leu Arg Asn Phe Leu Lys Cys Ser Glu Asp Asn 
865                 870                 875                 880 


Pro Leu Phe Ala Gly Ile Asp Cys Glu Val Phe Glu Ser Arg Phe Pro 
                885                 890                 895     


Thr Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala 
            900                 905                 910         


Leu Asn Ser Val Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp 
        915                 920                 925             


Met Asn Pro Trp Leu Leu Val Ala Val Ala Met Ser Met Ala Leu His 
    930                 935                 940                 


Phe Leu Ile Leu Leu Val Pro Pro Leu Pro Leu Ile Phe Gln Val Thr 
945                 950                 955                 960 


Pro Leu Ser Gly Arg Gln Trp Val Val Val Leu Gln Ile Ser Leu Pro 
                965                 970                 975     


Val Ile Leu Leu Asp Glu Ala Leu Lys Tyr Leu Ser Arg Asn His Met 
            980                 985                 990         


His Ala Cys Leu Tyr Pro Gly Leu  Leu Arg Thr Val Ser  Gln Ala Trp 
        995                 1000                 1005             


Ser Arg  Gln Pro Leu Thr Thr  Ser Trp Thr Pro Asp  His Thr Gly 
    1010                 1015                 1020             


Ala Arg  Asp Thr Ala Ser Ser  Arg Cys Gln Ser Cys  Ser Glu Arg 
    1025                 1030                 1035             


Glu Glu  Ala Gly Lys Lys 
    1040                 


<210>  6419
<211>  1043
<212>  PRT
<213>  Homo sapiens

<400>  6419

Met Glu Ala Ala His Leu Leu Pro Ala Ala Asp Val Leu Arg His Phe 
1               5                   10                  15      


Ser Val Thr Ala Glu Gly Gly Leu Ser Pro Ala Gln Val Thr Gly Ala 
            20                  25                  30          


Arg Glu Arg Tyr Gly Pro Asn Glu Leu Pro Ser Glu Glu Gly Lys Ser 
        35                  40                  45              


Leu Trp Glu Leu Val Leu Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Leu Val Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Thr Thr Ala Phe Val Glu Pro Leu Val Ile Met Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Ser Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Ile Arg Ser Asp Arg Lys Gly Val Gln Arg Ile Arg Ala Arg Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Leu Arg Leu Ile Glu Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Thr Lys His Thr Glu 
            180                 185                 190         


Ala Ile Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Thr Ser Gly Lys Ala Val Gly Val Ala Val 
    210                 215                 220                 


Ala Thr Gly Leu His Thr Glu Leu Gly Lys Ile Arg Ser Gln Met Ala 
225                 230                 235                 240 


Ala Val Glu Pro Glu Arg Thr Pro Leu Gln Arg Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Arg Gln Leu Ser His Ala Ile Ser Val Ile Cys Val Ala Val Trp 
            260                 265                 270         


Val Ile Asn Ile Gly His Phe Ala Asp Pro Ala His Gly Gly Ser Trp 
        275                 280                 285             


Leu Arg Gly Ala Val Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Arg Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Val 
        355                 360                 365             


Val Ala Glu Ala Asp Ala Gly Ser Cys Leu Leu His Glu Phe Thr Ile 
    370                 375                 380                 


Ser Gly Thr Thr Tyr Thr Pro Glu Gly Glu Val Arg Gln Gly Asp Gln 
385                 390                 395                 400 


Pro Val Arg Cys Gly Gln Phe Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Asp Leu Gln Ala Leu Ser Arg 
    450                 455                 460                 


Val Glu Arg Ala Gly Ala Cys Asn Thr Val Ile Lys Gln Leu Met Arg 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Thr Arg Pro His Pro Thr Gly Gln Gly Ser Lys Met 
            500                 505                 510         


Phe Val Lys Gly Ala Pro Glu Ser Val Ile Glu Arg Cys Ser Ser Val 
        515                 520                 525             


Arg Val Gly Ser Arg Thr Ala Pro Leu Thr Pro Thr Ser Arg Glu Gln 
    530                 535                 540                 


Ile Leu Ala Lys Ile Arg Asp Trp Gly Ser Gly Ser Asp Thr Leu Arg 
545                 550                 555                 560 


Cys Leu Ala Leu Ala Thr Arg Asp Ala Pro Pro Arg Lys Glu Asp Met 
                565                 570                 575     


Glu Leu Asp Asp Cys Ser Lys Phe Val Gln Tyr Glu Thr Asp Leu Thr 
            580                 585                 590         


Phe Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Pro Glu Val Ala 
        595                 600                 605             


Ala Cys Ile Thr Arg Cys Tyr Gln Ala Gly Ile Arg Val Val Met Ile 
    610                 615                 620                 


Thr Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Leu Gly 
625                 630                 635                 640 


Ile Phe Gly Asp Thr Glu Asp Val Ala Gly Lys Ala Tyr Thr Gly Arg 
                645                 650                 655     


Glu Phe Asp Asp Leu Ser Pro Glu Gln Gln Arg Gln Ala Cys Arg Thr 
            660                 665                 670         


Ala Arg Cys Phe Ala Arg Val Glu Pro Ala His Lys Ser Arg Ile Val 
        675                 680                 685             


Glu Asn Leu Gln Ser Phe Asn Glu Ile Thr Ala Met Thr Gly Asp Gly 
    690                 695                 700                 


Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met 
705                 710                 715                 720 


Gly Ser Gly Thr Ala Val Ala Lys Ser Ala Ala Glu Met Val Leu Ser 
                725                 730                 735     


Asp Asp Asn Phe Ala Ser Ile Val Ala Ala Val Glu Glu Gly Arg Ala 
            740                 745                 750         


Ile Tyr Ser Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn 
        755                 760                 765             


Val Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ile Leu Gly Leu Pro 
    770                 775                 780                 


Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp 
785                 790                 795                 800 


Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile 
                805                 810                 815     


Met Glu Lys Leu Pro Arg Ser Pro Arg Glu Ala Leu Ile Ser Gly Trp 
            820                 825                 830         


Leu Phe Phe Arg Tyr Leu Ala Ile Gly Val Tyr Val Gly Leu Ala Thr 
        835                 840                 845             


Val Ala Ala Ala Thr Trp Trp Phe Val Tyr Asp Ala Glu Gly Pro His 
    850                 855                 860                 


Ile Asn Phe Tyr Gln Leu Arg Asn Phe Leu Lys Cys Ser Glu Asp Asn 
865                 870                 875                 880 


Pro Leu Phe Ala Gly Ile Asp Cys Glu Val Phe Glu Ser Arg Phe Pro 
                885                 890                 895     


Thr Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala 
            900                 905                 910         


Leu Asn Ser Val Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp 
        915                 920                 925             


Met Asn Pro Trp Leu Leu Val Ala Val Ala Met Ser Met Ala Leu His 
    930                 935                 940                 


Phe Leu Ile Leu Leu Val Pro Pro Leu Pro Leu Ile Phe Gln Val Thr 
945                 950                 955                 960 


Pro Leu Ser Gly Arg Gln Trp Val Val Val Leu Gln Ile Ser Leu Pro 
                965                 970                 975     


Val Ile Leu Leu Asp Glu Ala Leu Lys Tyr Leu Ser Arg Asn His Met 
            980                 985                 990         


His Ala Cys Leu Tyr Pro Gly Leu  Leu Arg Thr Val Ser  Gln Ala Trp 
        995                 1000                 1005             


Ser Arg  Gln Pro Leu Thr Thr  Ser Trp Thr Pro Asp  His Thr Gly 
    1010                 1015                 1020             


Arg Asn  Glu Pro Glu Val Ser  Ala Gly Asn Arg Val  Glu Ser Pro 
    1025                 1030                 1035             


Val Cys  Thr Ser Asp 
    1040             


<210>  6420
<211>  1029
<212>  PRT
<213>  Homo sapiens

<400>  6420

Met Glu Ala Ala His Leu Leu Pro Ala Ala Asp Val Leu Arg His Phe 
1               5                   10                  15      


Ser Val Thr Ala Glu Gly Gly Leu Ser Pro Ala Gln Val Thr Gly Ala 
            20                  25                  30          


Arg Glu Arg Tyr Gly Pro Asn Glu Leu Pro Ser Glu Glu Gly Lys Ser 
        35                  40                  45              


Leu Trp Glu Leu Val Leu Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Leu Val Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Thr Thr Ala Phe Val Glu Pro Leu Val Ile Met Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Ser Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Ile Arg Ser Asp Arg Lys Gly Val Gln Arg Ile Arg Ala Arg Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Leu Arg Leu Ile Glu Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Thr Lys His Thr Glu 
            180                 185                 190         


Ala Ile Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Thr Ser Gly Lys Ala Val Gly Val Ala Val 
    210                 215                 220                 


Ala Thr Gly Leu His Thr Glu Leu Gly Lys Ile Arg Ser Gln Met Ala 
225                 230                 235                 240 


Ala Val Glu Pro Glu Arg Thr Pro Leu Gln Arg Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Arg Gln Leu Ser His Ala Ile Ser Val Ile Cys Val Ala Val Trp 
            260                 265                 270         


Val Ile Asn Ile Gly His Phe Ala Asp Pro Ala His Gly Gly Ser Trp 
        275                 280                 285             


Leu Arg Gly Ala Val Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Arg Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Val 
        355                 360                 365             


Val Ala Glu Ala Asp Ala Gly Ser Cys Leu Leu His Glu Phe Thr Ile 
    370                 375                 380                 


Ser Gly Thr Thr Tyr Thr Pro Glu Gly Glu Val Arg Gln Gly Asp Gln 
385                 390                 395                 400 


Pro Val Arg Cys Gly Gln Phe Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Asp Leu Gln Ala Leu Ser Arg 
    450                 455                 460                 


Val Glu Arg Ala Gly Ala Cys Asn Thr Val Ile Lys Gln Leu Met Arg 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Thr Arg Pro His Pro Thr Gly Gln Gly Ser Lys Met 
            500                 505                 510         


Phe Val Lys Gly Ala Pro Glu Ser Val Ile Glu Arg Cys Ser Ser Val 
        515                 520                 525             


Arg Val Gly Ser Arg Thr Ala Pro Leu Thr Pro Thr Ser Arg Glu Gln 
    530                 535                 540                 


Ile Leu Ala Lys Ile Arg Asp Trp Gly Ser Gly Ser Asp Thr Leu Arg 
545                 550                 555                 560 


Cys Leu Ala Leu Ala Thr Arg Asp Ala Pro Pro Arg Lys Glu Asp Met 
                565                 570                 575     


Glu Leu Asp Asp Cys Ser Lys Phe Val Gln Tyr Glu Thr Asp Leu Thr 
            580                 585                 590         


Phe Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Pro Glu Val Ala 
        595                 600                 605             


Ala Cys Ile Thr Arg Cys Tyr Gln Ala Gly Ile Arg Val Val Met Ile 
    610                 615                 620                 


Thr Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Leu Gly 
625                 630                 635                 640 


Ile Phe Gly Asp Thr Glu Asp Val Ala Gly Lys Ala Tyr Thr Gly Arg 
                645                 650                 655     


Glu Phe Asp Asp Leu Ser Pro Glu Gln Gln Arg Gln Ala Cys Arg Thr 
            660                 665                 670         


Ala Arg Cys Phe Ala Arg Val Glu Pro Ala His Lys Ser Arg Ile Val 
        675                 680                 685             


Glu Asn Leu Gln Ser Phe Asn Glu Ile Thr Ala Met Thr Gly Asp Gly 
    690                 695                 700                 


Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met 
705                 710                 715                 720 


Gly Ser Gly Thr Ala Val Ala Lys Ser Ala Ala Glu Met Val Leu Ser 
                725                 730                 735     


Asp Asp Asn Phe Ala Ser Ile Val Ala Ala Val Glu Glu Gly Arg Ala 
            740                 745                 750         


Ile Tyr Ser Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn 
        755                 760                 765             


Val Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ile Leu Gly Leu Pro 
    770                 775                 780                 


Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp 
785                 790                 795                 800 


Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile 
                805                 810                 815     


Met Glu Lys Leu Pro Arg Ser Pro Arg Glu Ala Leu Ile Ser Gly Trp 
            820                 825                 830         


Leu Phe Phe Arg Tyr Leu Ala Ile Gly Val Tyr Val Gly Leu Ala Thr 
        835                 840                 845             


Val Ala Ala Ala Thr Trp Trp Phe Val Tyr Asp Ala Glu Gly Pro His 
    850                 855                 860                 


Ile Asn Phe Tyr Gln Leu Arg Asn Phe Leu Lys Cys Ser Glu Asp Asn 
865                 870                 875                 880 


Pro Leu Phe Ala Gly Ile Asp Cys Glu Val Phe Glu Ser Arg Phe Pro 
                885                 890                 895     


Thr Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala 
            900                 905                 910         


Leu Asn Ser Val Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp 
        915                 920                 925             


Met Asn Pro Trp Leu Leu Val Ala Val Ala Met Ser Met Ala Leu His 
    930                 935                 940                 


Phe Leu Ile Leu Leu Val Pro Pro Leu Pro Leu Ile Phe Gln Val Thr 
945                 950                 955                 960 


Pro Leu Ser Gly Arg Gln Trp Val Val Val Leu Gln Ile Ser Leu Pro 
                965                 970                 975     


Val Ile Leu Leu Asp Glu Ala Leu Lys Tyr Leu Ser Arg Asn His Met 
            980                 985                 990         


His Ala Cys Leu Tyr Pro Gly Leu  Leu Arg Thr Val Ser  Gln Ala Trp 
        995                 1000                 1005             


Ser Arg  Gln Pro Leu Thr Thr  Ser Trp Thr Pro Asp  His Thr Gly 
    1010                 1015                 1020             


Leu Ala  Ser Leu Lys Lys 
    1025                 


<210>  6421
<211>  998
<212>  PRT
<213>  Homo sapiens

<400>  6421

Met Glu Ala Ala His Leu Leu Pro Ala Ala Asp Val Leu Arg His Phe 
1               5                   10                  15      


Ser Val Thr Ala Glu Gly Gly Leu Ser Pro Ala Gln Val Thr Gly Ala 
            20                  25                  30          


Arg Glu Arg Tyr Gly Pro Asn Glu Leu Pro Ser Glu Glu Gly Lys Ser 
        35                  40                  45              


Leu Trp Glu Leu Val Leu Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Leu Val Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Thr Thr Ala Phe Val Glu Pro Leu Val Ile Met Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Ser Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Ile Arg Ser Asp Arg Lys Gly Val Gln Arg Ile Arg Ala Arg Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Leu Arg Leu Ile Glu Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Thr Lys His Thr Glu 
            180                 185                 190         


Ala Ile Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Thr Ser Gly Lys Ala Val Gly Val Ala Val 
    210                 215                 220                 


Ala Thr Gly Leu His Thr Glu Leu Gly Lys Ile Arg Ser Gln Met Ala 
225                 230                 235                 240 


Ala Val Glu Pro Glu Arg Thr Pro Leu Gln Arg Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Arg Gln Leu Ser His Ala Ile Ser Val Ile Cys Val Ala Val Trp 
            260                 265                 270         


Val Ile Asn Ile Gly His Phe Ala Asp Pro Ala His Gly Gly Ser Trp 
        275                 280                 285             


Leu Arg Gly Ala Val Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Arg Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Val 
        355                 360                 365             


Val Ala Glu Ala Asp Ala Gly Ser Cys Leu Leu His Glu Phe Thr Ile 
    370                 375                 380                 


Ser Gly Thr Thr Tyr Thr Pro Glu Gly Glu Val Arg Gln Gly Asp Gln 
385                 390                 395                 400 


Pro Val Arg Cys Gly Gln Phe Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Asp Leu Gln Ala Leu Ser Arg 
    450                 455                 460                 


Val Glu Arg Ala Gly Ala Cys Asn Thr Val Ile Lys Gln Leu Met Arg 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Thr Arg Pro His Pro Thr Gly Gln Gly Ser Lys Met 
            500                 505                 510         


Phe Val Lys Gly Ala Pro Glu Ser Val Ile Glu Arg Cys Ser Ser Val 
        515                 520                 525             


Arg Val Gly Ser Arg Thr Ala Pro Leu Thr Pro Thr Ser Arg Glu Gln 
    530                 535                 540                 


Ile Leu Ala Lys Ile Arg Asp Trp Gly Ser Gly Ser Asp Thr Leu Arg 
545                 550                 555                 560 


Cys Leu Ala Leu Ala Thr Arg Asp Ala Pro Pro Arg Lys Glu Asp Met 
                565                 570                 575     


Glu Leu Asp Asp Cys Ser Lys Phe Val Gln Tyr Glu Thr Asp Leu Thr 
            580                 585                 590         


Phe Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Pro Glu Val Ala 
        595                 600                 605             


Ala Cys Ile Thr Arg Cys Tyr Gln Ala Gly Ile Arg Val Val Met Ile 
    610                 615                 620                 


Thr Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Leu Gly 
625                 630                 635                 640 


Ile Phe Gly Asp Thr Glu Asp Val Ala Gly Lys Ala Tyr Thr Gly Arg 
                645                 650                 655     


Glu Phe Asp Asp Leu Ser Pro Glu Gln Gln Arg Gln Ala Cys Arg Thr 
            660                 665                 670         


Ala Arg Cys Phe Ala Arg Val Glu Pro Ala His Lys Ser Arg Ile Val 
        675                 680                 685             


Glu Asn Leu Gln Ser Phe Asn Glu Ile Thr Ala Met Thr Gly Asp Gly 
    690                 695                 700                 


Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met 
705                 710                 715                 720 


Gly Ser Gly Thr Ala Val Ala Lys Ser Ala Ala Glu Met Val Leu Ser 
                725                 730                 735     


Asp Asp Asn Phe Ala Ser Ile Val Ala Ala Val Glu Glu Gly Arg Ala 
            740                 745                 750         


Ile Tyr Ser Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn 
        755                 760                 765             


Val Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ile Leu Gly Leu Pro 
    770                 775                 780                 


Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp 
785                 790                 795                 800 


Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile 
                805                 810                 815     


Met Glu Lys Leu Pro Arg Ser Pro Arg Glu Ala Leu Ile Ser Gly Trp 
            820                 825                 830         


Leu Phe Phe Arg Tyr Leu Ala Ile Gly Val Tyr Val Gly Leu Ala Thr 
        835                 840                 845             


Val Ala Ala Ala Thr Trp Trp Phe Val Tyr Asp Ala Glu Gly Pro His 
    850                 855                 860                 


Ile Asn Phe Tyr Gln Leu Arg Asn Phe Leu Lys Cys Ser Glu Asp Asn 
865                 870                 875                 880 


Pro Leu Phe Ala Gly Ile Asp Cys Glu Val Phe Glu Ser Arg Phe Pro 
                885                 890                 895     


Thr Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala 
            900                 905                 910         


Leu Asn Ser Val Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp 
        915                 920                 925             


Met Asn Pro Trp Leu Leu Val Ala Val Ala Met Ser Met Ala Leu His 
    930                 935                 940                 


Phe Leu Ile Leu Leu Val Pro Pro Leu Pro Leu Ile Phe Gln Val Thr 
945                 950                 955                 960 


Pro Leu Ser Gly Arg Gln Trp Val Val Val Leu Gln Ile Ser Leu Pro 
                965                 970                 975     


Val Ile Leu Leu Asp Glu Ala Leu Lys Tyr Leu Ser Arg Asn His Met 
            980                 985                 990         


His Glu Met Ser Gln Lys 
        995             


<210>  6422
<211>  1029
<212>  PRT
<213>  Homo sapiens

<400>  6422

Met Glu Ala Ala His Leu Leu Pro Ala Ala Asp Val Leu Arg His Phe 
1               5                   10                  15      


Ser Val Thr Ala Glu Gly Gly Leu Ser Pro Ala Gln Val Thr Gly Ala 
            20                  25                  30          


Arg Glu Arg Tyr Gly Pro Asn Glu Leu Pro Ser Glu Glu Gly Lys Ser 
        35                  40                  45              


Leu Trp Glu Leu Val Leu Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Leu Val Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Thr Thr Ala Phe Val Glu Pro Leu Val Ile Met Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Ser Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Ile Arg Ser Asp Arg Lys Gly Val Gln Arg Ile Arg Ala Arg Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Leu Arg Leu Ile Glu Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Thr Lys His Thr Glu 
            180                 185                 190         


Ala Ile Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Thr Ser Gly Lys Ala Val Gly Val Ala Val 
    210                 215                 220                 


Ala Thr Gly Leu His Thr Glu Leu Gly Lys Ile Arg Ser Gln Met Ala 
225                 230                 235                 240 


Ala Val Glu Pro Glu Arg Thr Pro Leu Gln Arg Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Arg Gln Leu Ser His Ala Ile Ser Val Ile Cys Val Ala Val Trp 
            260                 265                 270         


Val Ile Asn Ile Gly His Phe Ala Asp Pro Ala His Gly Gly Ser Trp 
        275                 280                 285             


Leu Arg Gly Ala Val Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Arg Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Val 
        355                 360                 365             


Val Ala Glu Ala Asp Ala Gly Ser Cys Leu Leu His Glu Phe Thr Ile 
    370                 375                 380                 


Ser Gly Thr Thr Tyr Thr Pro Glu Gly Glu Val Arg Gln Gly Asp Gln 
385                 390                 395                 400 


Pro Val Arg Cys Gly Gln Phe Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Asp Leu Gln Ala Leu Ser Arg 
    450                 455                 460                 


Val Glu Arg Ala Gly Ala Cys Asn Thr Val Ile Lys Gln Leu Met Arg 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Thr Arg Pro His Pro Thr Gly Gln Gly Ser Lys Met 
            500                 505                 510         


Phe Val Lys Gly Ala Pro Glu Ser Val Ile Glu Arg Cys Ser Ser Val 
        515                 520                 525             


Arg Val Gly Ser Arg Thr Ala Pro Leu Thr Pro Thr Ser Arg Glu Gln 
    530                 535                 540                 


Ile Leu Ala Lys Ile Arg Asp Trp Gly Ser Gly Ser Asp Thr Leu Arg 
545                 550                 555                 560 


Cys Leu Ala Leu Ala Thr Arg Asp Ala Pro Pro Arg Lys Glu Asp Met 
                565                 570                 575     


Glu Leu Asp Asp Cys Ser Lys Phe Val Gln Tyr Glu Thr Asp Leu Thr 
            580                 585                 590         


Phe Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Pro Glu Val Ala 
        595                 600                 605             


Ala Cys Ile Thr Arg Cys Tyr Gln Ala Gly Ile Arg Val Val Met Ile 
    610                 615                 620                 


Thr Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Leu Gly 
625                 630                 635                 640 


Ile Phe Gly Asp Thr Glu Asp Val Ala Gly Lys Ala Tyr Thr Gly Arg 
                645                 650                 655     


Glu Phe Asp Asp Leu Ser Pro Glu Gln Gln Arg Gln Ala Cys Arg Thr 
            660                 665                 670         


Ala Arg Cys Phe Ala Arg Val Glu Pro Ala His Lys Ser Arg Ile Val 
        675                 680                 685             


Glu Asn Leu Gln Ser Phe Asn Glu Ile Thr Ala Met Thr Gly Asp Gly 
    690                 695                 700                 


Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met 
705                 710                 715                 720 


Gly Ser Gly Thr Ala Val Ala Lys Ser Ala Ala Glu Met Val Leu Ser 
                725                 730                 735     


Asp Asp Asn Phe Ala Ser Ile Val Ala Ala Val Glu Glu Gly Arg Ala 
            740                 745                 750         


Ile Tyr Ser Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn 
        755                 760                 765             


Val Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ile Leu Gly Leu Pro 
    770                 775                 780                 


Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp 
785                 790                 795                 800 


Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile 
                805                 810                 815     


Met Glu Lys Leu Pro Arg Ser Pro Arg Glu Ala Leu Ile Ser Gly Trp 
            820                 825                 830         


Leu Phe Phe Arg Tyr Leu Ala Ile Gly Val Tyr Val Gly Leu Ala Thr 
        835                 840                 845             


Val Ala Ala Ala Thr Trp Trp Phe Val Tyr Asp Ala Glu Gly Pro His 
    850                 855                 860                 


Ile Asn Phe Tyr Gln Leu Arg Asn Phe Leu Lys Cys Ser Glu Asp Asn 
865                 870                 875                 880 


Pro Leu Phe Ala Gly Ile Asp Cys Glu Val Phe Glu Ser Arg Phe Pro 
                885                 890                 895     


Thr Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala 
            900                 905                 910         


Leu Asn Ser Val Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp 
        915                 920                 925             


Met Asn Pro Trp Leu Leu Val Ala Val Ala Met Ser Met Ala Leu His 
    930                 935                 940                 


Phe Leu Ile Leu Leu Val Pro Pro Leu Pro Leu Ile Phe Gln Val Thr 
945                 950                 955                 960 


Pro Leu Ser Gly Arg Gln Trp Val Val Val Leu Gln Ile Ser Leu Pro 
                965                 970                 975     


Val Ile Leu Leu Asp Glu Ala Leu Lys Tyr Leu Ser Arg Asn His Met 
            980                 985                 990         


His Ala Cys Leu Tyr Pro Gly Leu  Leu Arg Thr Val Ser  Gln Ala Trp 
        995                 1000                 1005             


Ser Arg  Gln Pro Leu Thr Thr  Ser Trp Thr Pro Asp  His Thr Gly 
    1010                 1015                 1020             


Leu Ala  Ser Leu Lys Lys 
    1025                 


<210>  6423
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  6423

Met Ala Ala Gly Arg Leu Ile Ile Lys Thr Glu Phe Leu Pro Thr Lys 
1               5                   10                  15      


Tyr Arg Gly Tyr Met Leu Pro Leu Ser Gln Val Phe Trp Leu Ala Gly 
            20                  25                  30          


Ser Leu Leu Ile Ile Gly Leu Ala Ser Val Ile Ile Pro Thr Ile Gly 
        35                  40                  45              


Trp Arg Trp Leu Ile Arg Val Ala Ser Ile Pro Gly Ile Ile Leu Ile 
    50                  55                  60                  


Val Ala Phe Lys Phe Ile Pro Glu Ser Ala Arg Phe Asn Val Ser Thr 
65                  70                  75                  80  


Gly Asn Thr Arg Ala Ala Leu Ala Thr Leu Glu Arg Val Ala Lys Met 
                85                  90                  95      


Asn Arg Ser Val Met Pro Glu Gly Lys Leu Val Glu Pro Val Leu Glu 
            100                 105                 110         


Lys Arg Gly Arg Phe Ala Asp Leu Leu Asp Ala Lys Tyr Leu Arg Thr 
        115                 120                 125             


Thr Leu Gln Ile Trp Val Ile Trp Leu Gly Ile Ser Phe Ala Tyr Tyr 
    130                 135                 140                 


Gly Val Ile Leu Ala Ser Ala Glu Leu Leu Glu Arg Asp Leu Val Cys 
145                 150                 155                 160 


Gly Ser Lys Ser Asp Ser Ala Val Val Val Thr Gly Gly Asp Ser Gly 
                165                 170                 175     


Glu Ser Gln Ser Pro Cys Tyr Cys His Met Phe Ala Pro Ser Asp Tyr 
            180                 185                 190         


Arg Thr Met Ile Ile Ser Thr Ile Gly Glu Ile Ala Leu Asn Pro Leu 
        195                 200                 205             


Asn Ile Leu Gly Ile Asn Phe Leu Gly Arg Arg Leu Ser Leu Ser Ile 
    210                 215                 220                 


Thr Met Gly Cys Thr Ala Leu Phe Phe Leu Leu Leu Asn Ile Cys Thr 
225                 230                 235                 240 


Ser Ser Ala Gly Leu Ile Gly Phe Leu Phe Met Leu Arg Ala Leu Val 
                245                 250                 255     


Ala Ala Asn Phe Asn Thr Val Tyr Ile Tyr Thr Ala Glu Val Tyr Pro 
            260                 265                 270         


Thr Thr Met Arg Ala Leu Gly Met Gly Thr Ser Gly Ser Leu Cys Arg 
        275                 280                 285             


Ile Gly Ala Met Val Ala Pro Phe Ile Ser Gln Val Leu Met Ser Ala 
    290                 295                 300                 


Ser Ile Leu Gly Ala Leu Cys Leu Phe Ser Ser Val Cys Val Val Cys 
305                 310                 315                 320 


Ala Ile Ser Ala Phe Thr Leu Pro Ile Glu Thr Lys Gly Arg Ala Leu 
                325                 330                 335     


Gln Gln Ile Lys 
            340 


<210>  6424
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  6424

Met Gly Leu Leu Val Phe Val Arg Asn Leu Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Phe Leu Val Leu Gly Phe Leu Tyr Tyr Ser Ala Trp Lys Leu His Leu 
            20                  25                  30          


Leu Gln Trp Glu Glu Asp Ser Ser Lys Tyr Ser His Ser Ser Ser Pro 
        35                  40                  45              


Gln Glu Lys Pro Val Ala Asp Ser Val Val Leu Ser Phe Asp Ser Ala 
    50                  55                  60                  


Gly Gln Thr Leu Gly Ser Glu Tyr Asp Arg Leu Gly Phe Leu Leu Asn 
65                  70                  75                  80  


Leu Asp Ser Lys Leu Ser Pro Arg Thr Leu Cys Thr Val Val Phe Gly 
                85                  90                  95      


Leu Asp Cys Ile Leu Glu Ser Pro Gly Glu Pro Lys Lys Leu Leu Met 
            100                 105                 110         


Pro Ala Ser His Pro Leu Glu Ile Leu Lys Ser Leu Ser Glu Asp Thr 
        115                 120                 125             


Ala Phe Ala Leu Gly Phe Leu Lys Leu Pro Arg Pro Ala Glu Leu Ala 
    130                 135                 140                 


Thr Lys Tyr Ala Asn Phe Ser Glu Gly Ala Cys Lys Pro Gly Tyr Ala 
145                 150                 155                 160 


Ser Ala Leu Met Thr Ala Ile Phe Pro Arg Phe Ser Lys Pro Ala Pro 
                165                 170                 175     


Met Phe Leu Asp Asp Ser Phe Arg Lys Trp Ala Arg Ile Arg Glu Phe 
            180                 185                 190         


Val Pro Pro Phe Gly Ile Lys Gly Gln Asp Asn Leu Ile Lys Ala Ile 
        195                 200                 205             


Leu Ser Val Thr Lys Glu Tyr Arg Leu Thr Pro Ala Leu Asp Ser Leu 
    210                 215                 220                 


Arg Cys Arg Arg Cys Ile Ile Val Gly Asn Gly Gly Val Leu Ala Asn 
225                 230                 235                 240 


Lys Ser Leu Gly Ser Arg Ile Asp Asp Tyr Asp Ile Val Val Arg Leu 
                245                 250                 255     


Asn Ser Ala Pro Val Lys Gly Phe Glu Lys Asp Val Gly Ser Lys Thr 
            260                 265                 270         


Thr Leu Arg Ile Thr Tyr Pro Glu Gly Ala Met Gln Arg Pro Glu Gln 
        275                 280                 285             


Tyr Glu Arg Asp Ser Leu Phe Val Leu Ala Gly Phe Lys Trp Gln Asp 
    290                 295                 300                 


Phe Lys Trp Leu Lys Tyr Ile Val Tyr Lys Glu Arg Val Ser Ala Ser 
305                 310                 315                 320 


Asp Gly Phe Trp Lys Ser Val Ala Thr Arg Val Pro Lys Glu Pro Pro 
                325                 330                 335     


Glu Ile Arg Ile Leu Asn Pro Tyr Phe Ile Gln Glu Ala Ala Phe Thr 
            340                 345                 350         


Leu Ile Gly Leu Pro Phe Asn Asn Gly Leu Met Gly Arg Gly Asn Ile 
        355                 360                 365             


Pro Thr Leu Gly Ser Val Ala Val Thr Met Ala Leu His Gly Cys Asp 
    370                 375                 380                 


Glu Val Ala Val Ala Gly Phe Gly Tyr Asp Met Ser Thr Pro Asn Ala 
385                 390                 395                 400 


Pro Leu His Tyr Tyr Glu Thr Val Arg Met Ala Ala Ile Lys Glu Ser 
                405                 410                 415     


Trp Thr His Asn Ile Gln Arg Glu Lys Glu Phe Leu Arg Lys Leu Val 
            420                 425                 430         


Lys Ala Arg Val Ile Thr Asp Leu Ser Ser Gly Ile 
        435                 440                 


<210>  6425
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  6425

Met Gly Leu Leu Val Phe Val Arg Asn Leu Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Phe Leu Val Leu Gly Phe Leu Tyr Tyr Ser Ala Trp Lys Leu His Leu 
            20                  25                  30          


Leu Gln Trp Glu Glu Asp Ser Ser Lys Tyr Ser His Ser Ser Ser Pro 
        35                  40                  45              


Gln Glu Lys Pro Val Ala Asp Ser Val Val Leu Ser Phe Asp Ser Ala 
    50                  55                  60                  


Gly Gln Thr Leu Gly Ser Glu Tyr Asp Arg Leu Gly Phe Leu Leu Asn 
65                  70                  75                  80  


Leu Asp Ser Lys Leu Pro Ala Glu Leu Ala Thr Lys Tyr Ala Asn Phe 
                85                  90                  95      


Ser Glu Gly Ala Cys Lys Pro Gly Tyr Ala Ser Ala Leu Met Thr Ala 
            100                 105                 110         


Ile Phe Pro Arg Phe Ser Lys Pro Ala Pro Met Phe Leu Asp Asp Ser 
        115                 120                 125             


Phe Arg Lys Trp Ala Arg Ile Arg Glu Phe Val Pro Pro Phe Gly Ile 
    130                 135                 140                 


Lys Gly Gln Asp Asn Leu Ile Lys Ala Ile Leu Ser Val Thr Lys Glu 
145                 150                 155                 160 


Tyr Arg Leu Thr Pro Ala Leu Asp Ser Leu Arg Cys Arg Arg Cys Ile 
                165                 170                 175     


Ile Val Gly Asn Gly Gly Val Leu Ala Asn Lys Ser Leu Gly Ser Arg 
            180                 185                 190         


Ile Asp Asp Tyr Asp Ile Val Val Arg Leu Asn Ser Ala Pro Val Lys 
        195                 200                 205             


Gly Phe Glu Lys Asp Val Gly Ser Lys Thr Thr Leu Arg Ile Thr Tyr 
    210                 215                 220                 


Pro Glu Gly Ala Met Gln Arg Pro Glu Gln Tyr Glu Arg Asp Ser Leu 
225                 230                 235                 240 


Phe Val Leu Ala Gly Phe Lys Trp Gln Asp Phe Lys Trp Leu Lys Tyr 
                245                 250                 255     


Ile Val Tyr Lys Glu Arg Val Ser Ala Ser Asp Gly Phe Trp Lys Ser 
            260                 265                 270         


Val Ala Thr Arg Val Pro Lys Glu Pro Pro Glu Ile Arg Ile Leu Asn 
        275                 280                 285             


Pro Tyr Phe Ile Gln Glu Ala Ala Phe Thr Leu Ile Gly Leu Pro Phe 
    290                 295                 300                 


Asn Asn Gly Leu Met Gly Arg Gly Asn Ile Pro Thr Leu Gly Ser Val 
305                 310                 315                 320 


Ala Val Thr Met Ala Leu His Gly Cys Asp Glu Val Ala Val Ala Gly 
                325                 330                 335     


Phe Gly Tyr Asp Met Ser Thr Pro Asn Ala Pro Leu His Tyr Tyr Glu 
            340                 345                 350         


Thr Val Arg Met Ala Ala Ile Lys Glu Ser Trp Thr His Asn Ile Gln 
        355                 360                 365             


Arg Glu Lys Glu Phe Leu Arg Lys Leu Val Lys Ala Arg Val Ile Thr 
    370                 375                 380                 


Asp Leu Ser Ser Gly Ile 
385                 390 


<210>  6426
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  6426

Met Gly Leu Leu Val Phe Val Arg Asn Leu Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Phe Leu Val Leu Gly Phe Leu Tyr Tyr Ser Ala Trp Lys Leu His Leu 
            20                  25                  30          


Leu Gln Trp Glu Glu Asp Ser Ser Lys Tyr Ser His Ser Ser Ser Pro 
        35                  40                  45              


Gln Glu Lys Pro Val Ala Asp Ser Val Val Leu Ser Phe Asp Ser Ala 
    50                  55                  60                  


Gly Gln Thr Leu Gly Ser Glu Tyr Asp Arg Leu Gly Phe Leu Leu Asn 
65                  70                  75                  80  


Leu Asp Ser Lys Leu Pro Ala Glu Leu Ala Thr Lys Tyr Ala Asn Phe 
                85                  90                  95      


Ser Glu Gly Ala Cys Lys Pro Gly Tyr Ala Ser Ala Leu Met Thr Ala 
            100                 105                 110         


Ile Phe Pro Arg Phe Ser Lys Pro Ala Pro Met Phe Leu Asp Asp Ser 
        115                 120                 125             


Phe Arg Lys Trp Ala Arg Ile Arg Glu Phe Val Pro Pro Phe Gly Ile 
    130                 135                 140                 


Lys Gly Gln Val Leu Asp Ala Gln Tyr Pro Ala Arg Glu Arg Val Ser 
145                 150                 155                 160 


Ala Glu Ala Gly Glu Ser Ser Arg His His 
                165                 170 


<210>  6427
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  6427

Met Gly Leu Leu Val Phe Val Arg Asn Leu Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Phe Leu Val Leu Gly Phe Leu Tyr Tyr Ser Ala Trp Lys Leu His Leu 
            20                  25                  30          


Leu Gln Trp Glu Glu Asp Ser Asn Ser Val Val Leu Ser Phe Asp Ser 
        35                  40                  45              


Ala Gly Gln Thr Leu Gly Ser Glu Tyr Asp Arg Leu Gly Phe Leu Leu 
    50                  55                  60                  


Asn Leu Asp Ser Lys Leu Pro Ala Glu Leu Ala Thr Lys Tyr Ala Asn 
65                  70                  75                  80  


Phe Ser Glu Gly Ala Cys Lys Pro Gly Tyr Ala Ser Ala Leu Met Thr 
                85                  90                  95      


Ala Ile Phe Pro Arg Phe Ser Lys Pro Ala Pro Met Phe Leu Asp Asp 
            100                 105                 110         


Ser Phe Arg Lys Trp Ala Arg Ile Arg Glu Phe Val Pro Pro Phe Gly 
        115                 120                 125             


Ile Lys Gly Gln Asp Asn Leu Ile Lys Ala Ile Leu Ser Val Thr Lys 
    130                 135                 140                 


Glu Tyr Arg Leu Thr Pro Ala Leu Asp Ser Leu Arg Cys Arg Arg Cys 
145                 150                 155                 160 


Ile Ile Val Gly Asn Gly Gly Val Leu Ala Asn Lys Ser Leu Gly Ser 
                165                 170                 175     


Arg Ile Asp Asp Tyr Asp Ile Val Val Arg Leu Asn Ser Ala Pro Val 
            180                 185                 190         


Lys Gly Phe Glu Lys Asp Val Gly Ser Lys Thr Thr Leu Arg Ile Thr 
        195                 200                 205             


Tyr Pro Glu Gly Ala Met Gln Arg Pro Glu Gln Tyr Glu Arg Asp Ser 
    210                 215                 220                 


Leu Phe Val Leu Ala Gly Phe Lys Trp Gln Asp Phe Lys Trp Leu Lys 
225                 230                 235                 240 


Tyr Ile Val Tyr Lys Glu Arg Val Ser Trp Thr His Asn Ile Gln Arg 
                245                 250                 255     


Glu Lys Glu Phe Leu Arg Lys Leu Val Lys Ala Arg Val Ile Thr Asp 
            260                 265                 270         


Leu Ser Ser Gly Ile 
        275         


<210>  6428
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  6428

Met Gly Leu Leu Val Phe Val Arg Asn Leu Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Phe Leu Val Leu Gly Phe Leu Tyr Tyr Ser Ala Trp Lys Leu His Leu 
            20                  25                  30          


Leu Gln Trp Glu Glu Asp Ser Asn Ser Val Val Leu Ser Phe Asp Ser 
        35                  40                  45              


Ala Gly Gln Thr Leu Gly Ser Glu Tyr Asp Arg Leu Gly Phe Leu Leu 
    50                  55                  60                  


Asn Leu Asp Ser Lys Leu Pro Ala Glu Leu Ala Thr Lys Tyr Ala Asn 
65                  70                  75                  80  


Phe Ser Glu Gly Ala Cys Lys Pro Gly Tyr Ala Ser Ala Leu Met Thr 
                85                  90                  95      


Ala Ile Phe Pro Arg Phe Ser Lys Pro Ala Pro Met Phe Leu Asp Asp 
            100                 105                 110         


Ser Phe Arg Lys Trp Ala Arg Ile Arg Glu Phe Val Pro Pro Phe Gly 
        115                 120                 125             


Ile Lys Gly Gln Val Leu Asp Ala Gln Tyr Pro Ala Arg Glu Arg Val 
    130                 135                 140                 


Ser Ala Glu Ala Gly Glu Ser Ser Arg His His 
145                 150                 155 


<210>  6429
<211>  429
<212>  PRT
<213>  Homo sapiens

<400>  6429

Met Gly Leu Leu Val Phe Val Arg Asn Leu Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Phe Leu Val Leu Gly Phe Leu Tyr Tyr Ser Ala Trp Lys Leu His Leu 
            20                  25                  30          


Leu Gln Trp Glu Glu Asp Ser Asn Ser Val Val Leu Ser Phe Asp Ser 
        35                  40                  45              


Ala Gly Gln Thr Leu Gly Ser Glu Tyr Asp Arg Leu Gly Phe Leu Leu 
    50                  55                  60                  


Asn Leu Asp Ser Lys Leu Ser Pro Arg Thr Leu Cys Thr Val Val Phe 
65                  70                  75                  80  


Gly Leu Asp Cys Ile Leu Glu Ser Pro Gly Glu Pro Lys Lys Leu Leu 
                85                  90                  95      


Met Pro Ala Ser His Pro Leu Glu Ile Leu Lys Ser Leu Ser Glu Asp 
            100                 105                 110         


Thr Ala Phe Ala Leu Gly Phe Leu Lys Leu Pro Arg Pro Ala Glu Leu 
        115                 120                 125             


Ala Thr Lys Tyr Ala Asn Phe Ser Glu Gly Ala Cys Lys Pro Gly Tyr 
    130                 135                 140                 


Ala Ser Ala Leu Met Thr Ala Ile Phe Pro Arg Phe Ser Lys Pro Ala 
145                 150                 155                 160 


Pro Met Phe Leu Asp Asp Ser Phe Arg Lys Trp Ala Arg Ile Arg Glu 
                165                 170                 175     


Phe Val Pro Pro Phe Gly Ile Lys Gly Gln Asp Asn Leu Ile Lys Ala 
            180                 185                 190         


Ile Leu Ser Val Thr Lys Glu Tyr Arg Leu Thr Pro Ala Leu Asp Ser 
        195                 200                 205             


Leu Arg Cys Arg Arg Cys Ile Ile Val Gly Asn Gly Gly Val Leu Ala 
    210                 215                 220                 


Asn Lys Ser Leu Gly Ser Arg Ile Asp Asp Tyr Asp Ile Val Val Arg 
225                 230                 235                 240 


Leu Asn Ser Ala Pro Val Lys Gly Phe Glu Lys Asp Val Gly Ser Lys 
                245                 250                 255     


Thr Thr Leu Arg Ile Thr Tyr Pro Glu Gly Ala Met Gln Arg Pro Glu 
            260                 265                 270         


Gln Tyr Glu Arg Asp Ser Leu Phe Val Leu Ala Gly Phe Lys Trp Gln 
        275                 280                 285             


Asp Phe Lys Trp Leu Lys Tyr Ile Val Tyr Lys Glu Arg Val Ser Ala 
    290                 295                 300                 


Ser Asp Gly Phe Trp Lys Ser Val Ala Thr Arg Val Pro Lys Glu Pro 
305                 310                 315                 320 


Pro Glu Ile Arg Ile Leu Asn Pro Tyr Phe Ile Gln Glu Ala Ala Phe 
                325                 330                 335     


Thr Leu Ile Gly Leu Pro Phe Asn Asn Gly Leu Met Gly Arg Gly Asn 
            340                 345                 350         


Ile Pro Thr Leu Gly Ser Val Ala Val Thr Met Ala Leu His Gly Cys 
        355                 360                 365             


Asp Glu Val Ala Val Ala Gly Phe Gly Tyr Asp Met Ser Thr Pro Asn 
    370                 375                 380                 


Ala Pro Leu His Tyr Tyr Glu Thr Val Arg Met Ala Ala Ile Lys Glu 
385                 390                 395                 400 


Ser Trp Thr His Asn Ile Gln Arg Glu Lys Glu Phe Leu Arg Lys Leu 
                405                 410                 415     


Val Lys Ala Arg Val Ile Thr Asp Leu Ser Ser Gly Ile 
            420                 425                 


<210>  6430
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  6430

Met Gly Leu Leu Val Phe Val Arg Asn Leu Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Phe Leu Val Leu Gly Phe Leu Tyr Tyr Ser Ala Trp Lys Leu His Leu 
            20                  25                  30          


Leu Gln Trp Glu Glu Asp Ser Lys Tyr Asp Arg Leu Gly Phe Leu Leu 
        35                  40                  45              


Asn Leu Asp Ser Lys Leu Pro Ala Glu Leu Ala Thr Lys Tyr Ala Asn 
    50                  55                  60                  


Phe Ser Glu Gly Ala Cys Lys Pro Gly Tyr Ala Ser Ala Leu Met Thr 
65                  70                  75                  80  


Ala Ile Phe Pro Arg Phe Ser Lys Pro Ala Pro Met Phe Leu Asp Asp 
                85                  90                  95      


Ser Phe Arg Lys Trp Ala Arg Ile Arg Glu Phe Val Pro Pro Phe Gly 
            100                 105                 110         


Ile Lys Gly Gln Asp Asn Leu Ile Lys Ala Ile Leu Ser Val Thr Lys 
        115                 120                 125             


Glu Tyr Arg Leu Thr Pro Ala Leu Asp Ser Leu Arg Cys Arg Arg Cys 
    130                 135                 140                 


Ile Ile Val Gly Asn Gly Gly Val Leu Ala Asn Lys Ser Leu Gly Ser 
145                 150                 155                 160 


Arg Ile Asp Asp Tyr Asp Ile Val Val Arg Leu Asn Ser Ala Pro Val 
                165                 170                 175     


Lys Gly Phe Glu Lys Asp Val Gly Ser Lys Thr Thr Leu Arg Ile Thr 
            180                 185                 190         


Tyr Pro Glu Gly Ala Met Gln Arg Pro Glu Gln Tyr Glu Arg Asp Ser 
        195                 200                 205             


Leu Phe Val Leu Ala Gly Phe Lys Trp Gln Asp Phe Lys Trp Leu Lys 
    210                 215                 220                 


Tyr Ile Val Tyr Lys Glu Arg Val Ser Ala Ser Asp Gly Phe Trp Lys 
225                 230                 235                 240 


Ser Val Ala Thr Arg Val Pro Lys Glu Pro Pro Glu Ile Arg Ile Leu 
                245                 250                 255     


Asn Pro Tyr Phe Ile Gln Glu Ala Ala Phe Thr Leu Ile Gly Leu Pro 
            260                 265                 270         


Phe Asn Asn Gly Leu Met Gly Arg Gly Asn Ile Pro Thr Leu Gly Ser 
        275                 280                 285             


Val Ala Val Thr Met Ala Leu His Gly Cys Asp Glu Val Ala Val Ala 
    290                 295                 300                 


Gly Phe Gly Tyr Asp Met Ser Thr Pro Asn Ala Pro Leu His Tyr Tyr 
305                 310                 315                 320 


Glu Thr Val Arg Met Ala Ala Ile Lys Glu Ser Trp Thr His Asn Ile 
                325                 330                 335     


Gln Arg Glu Lys Glu Phe Leu Arg Lys Leu Val Lys Ala Arg Val Ile 
            340                 345                 350         


Thr Asp Leu Ser Ser Gly Ile 
        355                 


<210>  6431
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  6431

Met Gly Leu Leu Val Phe Val Arg Asn Leu Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Phe Leu Val Leu Gly Phe Leu Tyr Tyr Ser Ala Trp Lys Leu His Leu 
            20                  25                  30          


Leu Gln Trp Glu Glu Asp Ser Lys Tyr Asp Arg Leu Gly Phe Leu Leu 
        35                  40                  45              


Asn Leu Asp Ser Lys Leu Pro Ala Glu Leu Ala Thr Lys Tyr Ala Asn 
    50                  55                  60                  


Phe Ser Glu Gly Ala Cys Lys Pro Gly Tyr Ala Ser Ala Leu Met Thr 
65                  70                  75                  80  


Ala Ile Phe Pro Arg Phe Ser Lys Pro Ala Pro Met Phe Leu Asp Asp 
                85                  90                  95      


Ser Phe Arg Lys Trp Ala Arg Ile Arg Glu Phe Val Pro Pro Phe Gly 
            100                 105                 110         


Ile Lys Gly Gln Val Leu Asp Ala Gln Tyr Pro Ala Arg Glu Arg Val 
        115                 120                 125             


Ser Ala Glu Ala Gly Glu Ser Ser Arg His His 
    130                 135                 


<210>  6432
<211>  413
<212>  PRT
<213>  Homo sapiens

<400>  6432

Met Gly Leu Leu Val Phe Val Arg Asn Leu Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Phe Leu Val Leu Gly Phe Leu Tyr Tyr Ser Ala Trp Lys Leu His Leu 
            20                  25                  30          


Leu Gln Trp Glu Glu Asp Ser Lys Tyr Asp Arg Leu Gly Phe Leu Leu 
        35                  40                  45              


Asn Leu Asp Ser Lys Leu Ser Pro Arg Thr Leu Cys Thr Val Val Phe 
    50                  55                  60                  


Gly Leu Asp Cys Ile Leu Glu Ser Pro Gly Glu Pro Lys Lys Leu Leu 
65                  70                  75                  80  


Met Pro Ala Ser His Pro Leu Glu Ile Leu Lys Ser Leu Ser Glu Asp 
                85                  90                  95      


Thr Ala Phe Ala Leu Gly Phe Leu Lys Leu Pro Arg Pro Ala Glu Leu 
            100                 105                 110         


Ala Thr Lys Tyr Ala Asn Phe Ser Glu Gly Ala Cys Lys Pro Gly Tyr 
        115                 120                 125             


Ala Ser Ala Leu Met Thr Ala Ile Phe Pro Arg Phe Ser Lys Pro Ala 
    130                 135                 140                 


Pro Met Phe Leu Asp Asp Ser Phe Arg Lys Trp Ala Arg Ile Arg Glu 
145                 150                 155                 160 


Phe Val Pro Pro Phe Gly Ile Lys Gly Gln Asp Asn Leu Ile Lys Ala 
                165                 170                 175     


Ile Leu Ser Val Thr Lys Glu Tyr Arg Leu Thr Pro Ala Leu Asp Ser 
            180                 185                 190         


Leu Arg Cys Arg Arg Cys Ile Ile Val Gly Asn Gly Gly Val Leu Ala 
        195                 200                 205             


Asn Lys Ser Leu Gly Ser Arg Ile Asp Asp Tyr Asp Ile Val Val Arg 
    210                 215                 220                 


Leu Asn Ser Ala Pro Val Lys Gly Phe Glu Lys Asp Val Gly Ser Lys 
225                 230                 235                 240 


Thr Thr Leu Arg Ile Thr Tyr Pro Glu Gly Ala Met Gln Arg Pro Glu 
                245                 250                 255     


Gln Tyr Glu Arg Asp Ser Leu Phe Val Leu Ala Gly Phe Lys Trp Gln 
            260                 265                 270         


Asp Phe Lys Trp Leu Lys Tyr Ile Val Tyr Lys Glu Arg Val Ser Ala 
        275                 280                 285             


Ser Asp Gly Phe Trp Lys Ser Val Ala Thr Arg Val Pro Lys Glu Pro 
    290                 295                 300                 


Pro Glu Ile Arg Ile Leu Asn Pro Tyr Phe Ile Gln Glu Ala Ala Phe 
305                 310                 315                 320 


Thr Leu Ile Gly Leu Pro Phe Asn Asn Gly Leu Met Gly Arg Gly Asn 
                325                 330                 335     


Ile Pro Thr Leu Gly Ser Val Ala Val Thr Met Ala Leu His Gly Cys 
            340                 345                 350         


Asp Glu Val Ala Val Ala Gly Phe Gly Tyr Asp Met Ser Thr Pro Asn 
        355                 360                 365             


Ala Pro Leu His Tyr Tyr Glu Thr Val Arg Met Ala Ala Ile Lys Glu 
    370                 375                 380                 


Ser Trp Thr His Asn Ile Gln Arg Glu Lys Glu Phe Leu Arg Lys Leu 
385                 390                 395                 400 


Val Lys Ala Arg Val Ile Thr Asp Leu Ser Ser Gly Ile 
                405                 410             


<210>  6433
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  6433

Met Leu Ala Leu Arg Leu Leu Asn Val Val Ala Pro Ala Tyr Phe Leu 
1               5                   10                  15      


Cys Ile Ser Leu Val Thr Phe Val Leu Gln Leu Phe Leu Phe Leu Pro 
            20                  25                  30          


Ser Met Arg Glu Asp Pro Ala Ala Ala Arg Leu Phe Ser Pro Ala Leu 
        35                  40                  45              


Leu His Gly Ala Leu Phe Leu Phe Leu Ser Ala Asn Ala Leu Gly Asn 
    50                  55                  60                  


Tyr Val Leu Val Ile Gln Asn Ser Pro Asp Asp Leu Gly Ala Cys Gln 
65                  70                  75                  80  


Gly Ala Ser Ala Arg Lys Thr Pro Cys Pro Ser Pro Ser Thr His Phe 
                85                  90                  95      


Cys Arg Val Cys Ala Arg Val Thr Leu Arg His Asp His His Cys Phe 
            100                 105                 110         


Phe Thr Gly Asn Cys Ile Gly Ser Arg Asn Met Arg Asn Phe Val Leu 
        115                 120                 125             


Phe Cys Leu Tyr Thr Ser Leu Ala Cys Leu Tyr Ser Met Val Ala Gly 
    130                 135                 140                 


Val Ala Tyr Ile Ser Ala Val Leu Ser Ile Ser Phe Ala His Pro Leu 
145                 150                 155                 160 


Ala Phe Leu Thr Leu Leu Pro Thr Ser Ile Ser Gln Phe Phe Ser Gly 
                165                 170                 175     


Ala Val Leu Gly Ser Glu Met Phe Val Ile Leu Met Leu Tyr Leu Trp 
            180                 185                 190         


Phe Ala Ile Gly Leu Ala Cys Ala Gly Phe Cys Cys His Gln Leu Leu 
        195                 200                 205             


Leu Ile Leu Arg Gly Gln Thr Arg His Gln Val Arg Lys Gly Val Ala 
    210                 215                 220                 


Val Arg Ala Arg Pro Trp Arg Lys Asn Leu Gln Glu Val Phe Gly Lys 
225                 230                 235                 240 


Arg Trp Leu Leu Gly Leu Leu Val Pro Met Phe Asn Val Gly Ser Glu 
                245                 250                 255     


Ser Ser Lys Gln Gln Asp Lys 
            260             


<210>  6434
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  6434

Met Gly Pro Gly Pro Pro Ala Ala Gly Ala Ala Pro Ser Pro Arg Pro 
1               5                   10                  15      


Leu Ser Leu Val Ala Arg Leu Ser Tyr Ala Val Gly His Phe Leu Asn 
            20                  25                  30          


Asp Leu Cys Ala Ser Met Trp Phe Thr Tyr Leu Leu Leu Tyr Leu His 
        35                  40                  45              


Ser Val Arg Ala Tyr Ser Ser Arg Gly Ala Gly Leu Leu Leu Leu Leu 
    50                  55                  60                  


Gly Gln Val Ala Asp Gly Leu Cys Thr Pro Leu Val Gly Tyr Glu Ala 
65                  70                  75                  80  


Asp Arg Ala Ala Ser Cys Cys Ala Arg Tyr Gly Pro Arg Lys Ala Trp 
                85                  90                  95      


His Leu Val Gly Thr Val Cys Val Leu Leu Ser Phe Pro Phe Ile Phe 
            100                 105                 110         


Ser Pro Cys Leu Gly Cys Gly Ala Ala Thr Pro Glu Trp Ala Ala Leu 
        115                 120                 125             


Leu Tyr Tyr Gly Pro Phe Ile Val Ile Phe Gln Phe Gly Trp Ala Ser 
    130                 135                 140                 


Thr Gln Ile Ser His Leu Ser Leu Ile Pro Glu Leu Val Thr Asn Asp 
145                 150                 155                 160 


His Glu Lys Val Glu Leu Thr Ala Leu Arg Tyr Ala Phe Thr Val Val 
                165                 170                 175     


Ala Asn Ile Thr Val Tyr Gly Ala Ala Trp Leu Leu Leu His Leu Gln 
            180                 185                 190         


Gly Ser Ser Arg Val Glu Pro Thr Gln Asp Ile Ser Ile Ser Asp Gln 
        195                 200                 205             


Leu Gly Gly Gln Asp Val Pro Val Phe Arg Asn Leu Ser Leu Leu Val 
    210                 215                 220                 


Val Gly Val Gly Ala Val Phe Ser Leu Leu Phe His Leu Gly Thr Arg 
225                 230                 235                 240 


Glu Arg Arg Arg Pro His Ala Glu Glu Pro Gly Glu His Thr Pro Leu 
                245                 250                 255     


Leu Ala Pro Ala Thr Ala Gln Pro Leu Leu Leu Trp Lys His Trp Leu 
            260                 265                 270         


Arg Glu Pro Ala Phe Tyr Gln Val Gly Ile Leu Tyr Met Thr Thr Arg 
        275                 280                 285             


Leu Ile Val Asn Leu Ser Gln Thr Tyr Met Ala Met Tyr Leu Thr Tyr 
    290                 295                 300                 


Ser Leu His Leu Pro Lys Lys Phe Ile Ala Thr Ile Pro Leu Val Met 
305                 310                 315                 320 


Tyr Leu Ser Gly Phe Leu Ser Ser Phe Leu Met Lys Pro Ile Asn Lys 
                325                 330                 335     


Cys Ile Gly Arg Asn Met Thr Tyr Phe Ser Gly Leu Leu Val Ile Leu 
            340                 345                 350         


Ala Phe Ala Ala Trp Val Ala Leu Ala Glu Gly Leu Gly Val Ala Val 
        355                 360                 365             


Tyr Ala Ala Ala Val Leu Leu Gly Ala Gly Cys Ala Thr Ile Leu Val 
    370                 375                 380                 


Thr Ser Leu Ala Met Thr Ala Asp Leu Ile Gly Pro His Thr Asn Ser 
385                 390                 395                 400 


Gly Ala Phe Val Tyr Gly Ser Met Ser Phe Leu Asp Lys Val Ala Asn 
                405                 410                 415     


Gly Leu Ala Val Met Ala Ile Gln Ser Leu His Pro Cys Pro Ser Glu 
            420                 425                 430         


Leu Cys Cys Arg Ala Cys Val Ser Phe Tyr His Trp Ala Met Val Ala 
        435                 440                 445             


Val Thr Gly Gly Val Gly Val Ala Ala Ala Leu Cys Leu Cys Ser Leu 
    450                 455                 460                 


Leu Leu Trp Pro Thr Arg Leu Arg Arg Trp Asp Arg Asp Ala Arg Pro 
465                 470                 475                 480 


<210>  6435
<211>  1007
<212>  PRT
<213>  Homo sapiens

<400>  6435

Met Lys Met Trp Leu Leu Val Ser His Leu Val Ile Ile Ser Ile Thr 
1               5                   10                  15      


Thr Cys Leu Ala Val Ser Glu Glu Asp Lys Gly Phe Gly Pro Ile Phe 
            20                  25                  30          


Glu Glu Gln Pro Ile Asn Thr Ile Tyr Pro Glu Glu Ser Leu Glu Gly 
        35                  40                  45              


Lys Val Ser Leu Asn Cys Arg Ala Arg Ala Ser Pro Phe Pro Val Tyr 
    50                  55                  60                  


Lys Trp Arg Met Asn Asn Gly Asp Val Asp Leu Thr Ser Asp Arg Tyr 
65                  70                  75                  80  


Ser Met Val Gly Gly Asn Leu Val Ile Asn Asn Pro Asp Lys Gln Lys 
                85                  90                  95      


Asp Ala Gly Ile Tyr Tyr Cys Leu Ala Ser Asn Asn Tyr Gly Met Val 
            100                 105                 110         


Arg Ser Thr Glu Ala Thr Leu Ser Phe Gly Tyr Leu Asp Pro Phe Pro 
        115                 120                 125             


Pro Glu Glu Arg Pro Glu Val Arg Val Lys Glu Gly Lys Gly Met Val 
    130                 135                 140                 


Leu Leu Cys Asp Pro Pro Tyr His Phe Pro Asp Asp Leu Ser Tyr Arg 
145                 150                 155                 160 


Trp Leu Leu Asn Glu Phe Pro Val Phe Ile Thr Met Asp Lys Arg Arg 
                165                 170                 175     


Phe Val Ser Gln Thr Asn Gly Asn Leu Tyr Ile Ala Asn Val Glu Ala 
            180                 185                 190         


Ser Asp Lys Gly Asn Tyr Ser Cys Phe Val Ser Ser Pro Ser Ile Thr 
        195                 200                 205             


Lys Ser Val Phe Ser Lys Phe Ile Pro Leu Ile Pro Ile Pro Glu Arg 
    210                 215                 220                 


Thr Thr Lys Pro Tyr Pro Ala Asp Ile Val Val Gln Phe Lys Asp Val 
225                 230                 235                 240 


Tyr Ala Leu Met Gly Gln Asn Val Thr Leu Glu Cys Phe Ala Leu Gly 
                245                 250                 255     


Asn Pro Val Pro Asp Ile Arg Trp Arg Lys Val Leu Glu Pro Met Pro 
            260                 265                 270         


Ser Thr Ala Glu Ile Ser Thr Ser Gly Ala Val Leu Lys Ile Phe Asn 
        275                 280                 285             


Ile Gln Leu Glu Asp Glu Gly Ile Tyr Glu Cys Glu Ala Glu Asn Ile 
    290                 295                 300                 


Arg Gly Lys Asp Lys His Gln Ala Arg Ile Tyr Val Gln Ala Phe Pro 
305                 310                 315                 320 


Glu Trp Val Glu His Ile Asn Asp Thr Glu Val Asp Ile Gly Ser Asp 
                325                 330                 335     


Leu Tyr Trp Pro Cys Val Ala Thr Gly Lys Pro Ile Pro Thr Ile Arg 
            340                 345                 350         


Trp Leu Lys Asn Gly Tyr Ala Tyr His Lys Gly Glu Leu Arg Leu Tyr 
        355                 360                 365             


Asp Val Thr Phe Glu Asn Ala Gly Met Tyr Gln Cys Ile Ala Glu Asn 
    370                 375                 380                 


Thr Tyr Gly Ala Ile Tyr Ala Asn Ala Glu Leu Lys Ile Leu Ala Leu 
385                 390                 395                 400 


Ala Pro Thr Phe Glu Met Asn Pro Met Lys Lys Lys Ile Leu Ala Ala 
                405                 410                 415     


Lys Gly Gly Arg Val Ile Ile Glu Cys Lys Pro Lys Ala Ala Pro Lys 
            420                 425                 430         


Pro Lys Phe Ser Trp Ser Lys Gly Thr Glu Trp Leu Val Asn Ser Ser 
        435                 440                 445             


Arg Ile Leu Ile Trp Glu Asp Gly Ser Leu Glu Ile Asn Asn Ile Thr 
    450                 455                 460                 


Arg Asn Asp Gly Gly Ile Tyr Thr Cys Phe Ala Glu Asn Asn Arg Gly 
465                 470                 475                 480 


Lys Ala Asn Ser Thr Gly Thr Leu Val Ile Thr Asp Pro Thr Arg Ile 
                485                 490                 495     


Ile Leu Ala Pro Ile Asn Ala Asp Ile Thr Val Gly Glu Asn Ala Thr 
            500                 505                 510         


Met Gln Cys Ala Ala Ser Phe Asp Pro Ala Leu Asp Leu Thr Phe Val 
        515                 520                 525             


Trp Ser Phe Asn Gly Tyr Val Ile Asp Phe Asn Lys Glu Asn Ile His 
    530                 535                 540                 


Tyr Gln Arg Asn Phe Met Leu Asp Ser Asn Gly Glu Leu Leu Ile Arg 
545                 550                 555                 560 


Asn Ala Gln Leu Lys His Ala Gly Arg Tyr Thr Cys Thr Ala Gln Thr 
                565                 570                 575     


Ile Val Asp Asn Ser Ser Ala Ser Ala Asp Leu Val Val Arg Gly Pro 
            580                 585                 590         


Pro Gly Pro Pro Gly Gly Leu Arg Ile Glu Asp Ile Arg Ala Thr Ser 
        595                 600                 605             


Val Ala Leu Thr Trp Ser Arg Gly Ser Asp Asn His Ser Pro Ile Ser 
    610                 615                 620                 


Lys Tyr Thr Ile Gln Thr Lys Thr Ile Leu Ser Asp Asp Trp Lys Asp 
625                 630                 635                 640 


Ala Lys Thr Asp Pro Pro Ile Ile Glu Gly Asn Met Glu Ala Ala Arg 
                645                 650                 655     


Ala Val Asp Leu Ile Pro Trp Met Glu Tyr Glu Phe Arg Val Val Ala 
            660                 665                 670         


Thr Asn Thr Leu Gly Arg Gly Glu Pro Ser Ile Pro Ser Asn Arg Ile 
        675                 680                 685             


Lys Thr Asp Gly Ala Ala Pro Asn Val Ala Pro Ser Asp Val Gly Gly 
    690                 695                 700                 


Gly Gly Gly Arg Asn Arg Glu Leu Thr Ile Thr Trp Ala Pro Leu Ser 
705                 710                 715                 720 


Arg Glu Tyr His Tyr Gly Asn Asn Phe Gly Tyr Ile Val Ala Phe Lys 
                725                 730                 735     


Pro Phe Asp Gly Glu Glu Trp Lys Lys Val Thr Val Thr Asn Pro Asp 
            740                 745                 750         


Thr Gly Arg Tyr Val His Lys Asp Glu Thr Met Ser Pro Ser Thr Ala 
        755                 760                 765             


Phe Gln Val Lys Val Lys Ala Phe Asn Asn Lys Gly Asp Gly Pro Tyr 
    770                 775                 780                 


Ser Leu Val Ala Val Ile Asn Ser Ala Gln Asp Ala Pro Ser Glu Ala 
785                 790                 795                 800 


Pro Thr Glu Val Gly Val Lys Val Leu Ser Ser Ser Glu Ile Ser Val 
                805                 810                 815     


His Trp Glu His Val Leu Glu Lys Ile Val Glu Ser Tyr Gln Ile Arg 
            820                 825                 830         


Tyr Trp Ala Ala His Asp Lys Glu Glu Ala Ala Asn Arg Val Gln Val 
        835                 840                 845             


Thr Ser Gln Glu Tyr Ser Ala Arg Leu Glu Asn Leu Leu Pro Asp Thr 
    850                 855                 860                 


Gln Tyr Phe Ile Glu Val Gly Ala Cys Asn Ser Ala Gly Cys Gly Pro 
865                 870                 875                 880 


Pro Ser Asp Met Ile Glu Ala Phe Thr Lys Lys Ala Pro Pro Ser Gln 
                885                 890                 895     


Pro Pro Arg Ile Ile Ser Ser Val Arg Ser Gly Ser Arg Tyr Ile Ile 
            900                 905                 910         


Thr Trp Asp His Val Val Ala Leu Ser Asn Glu Ser Thr Val Thr Gly 
        915                 920                 925             


Tyr Lys Val Leu Tyr Arg Pro Asp Gly Gln His Asp Gly Lys Leu Tyr 
    930                 935                 940                 


Ser Thr His Lys His Ser Ile Glu Val Pro Ile Pro Arg Asp Gly Glu 
945                 950                 955                 960 


Tyr Val Val Glu Val Arg Ala His Ser Asp Gly Gly Asp Gly Val Val 
                965                 970                 975     


Ser Gln Val Lys Ile Ser Gly Ala Pro Thr Leu Ser Pro Ser Leu Leu 
            980                 985                 990         


Gly Leu Leu Leu Pro Ala Phe Gly  Ile Leu Val Tyr Leu  Glu Phe 
        995                 1000                 1005         


<210>  6436
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  6436

Met Lys Ala Pro Gly Arg Leu Val Leu Ile Ile Leu Cys Ser Val Val 
1               5                   10                  15      


Phe Ser Ala Val Tyr Ile Leu Leu Cys Cys Trp Ala Gly Leu Pro Leu 
            20                  25                  30          


Cys Leu Ala Thr Cys Leu Asp His His Phe Pro Thr Gly Ser Arg Pro 
        35                  40                  45              


Thr Val Pro Gly Pro Leu His Phe Ser Gly Tyr Ser Ser Val Pro Asp 
    50                  55                  60                  


Gly Lys Pro Leu Val Arg Glu Pro Cys Arg Ser Cys Ala Val Val Ser 
65                  70                  75                  80  


Ser Ser Gly Gln Met Leu Gly Ser Gly Leu Gly Ala Glu Ile Asp Ser 
                85                  90                  95      


Ala Glu Cys Val Phe Arg Met Asn Gln Ala Pro Thr Val Gly Phe Glu 
            100                 105                 110         


Ala Asp Val Gly Gln Arg Ser Thr Leu Arg Val Val Ser His Thr Ser 
        115                 120                 125             


Val Pro Leu Leu Leu Arg Asn Tyr Ser His Tyr Phe Gln Lys Ala Arg 
    130                 135                 140                 


Asp Thr Leu Tyr Met Val Trp Gly Gln Gly Arg His Met Asp Arg Val 
145                 150                 155                 160 


Leu Gly Gly Arg Thr Tyr Arg Thr Leu Leu Gln Leu Thr Arg Met Tyr 
                165                 170                 175     


Pro Gly Leu Gln Val Tyr Thr Phe Thr Glu Arg Met Met Ala Tyr Cys 
            180                 185                 190         


Asp Gln Ile Phe Gln Asp Glu Thr Gly Lys Asn Arg Arg Gln Ser Gly 
        195                 200                 205             


Ser Phe Leu Ser Thr Gly Trp Phe Thr Met Ile Leu Ala Leu Glu Leu 
    210                 215                 220                 


Cys Glu Glu Ile Val Val Tyr Gly Met Val Ser Asp Ser Tyr Cys Arg 
225                 230                 235                 240 


Glu Lys Ser His Pro Ser Val Pro Tyr His Tyr Phe Glu Lys Gly Arg 
                245                 250                 255     


Leu Asp Glu Cys Gln Met Tyr Leu Ala His Glu Gln Ala Pro Arg Ser 
            260                 265                 270         


Ala His Arg Phe Ile Thr Glu Lys Ala Val Phe Ser Arg Trp Ala Lys 
        275                 280                 285             


Lys Arg Pro Ile Val Phe Ala His Pro Ser Trp Arg Thr Glu 
    290                 295                 300         


<210>  6437
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  6437

Met Leu Gly Ser Gly Leu Gly Ala Glu Ile Asp Ser Ala Glu Cys Val 
1               5                   10                  15      


Phe Arg Met Asn Gln Ala Pro Thr Val Gly Phe Glu Ala Asp Val Gly 
            20                  25                  30          


Gln Arg Ser Thr Leu Arg Val Val Ser His Thr Ser Val Pro Leu Leu 
        35                  40                  45              


Leu Arg Asn Tyr Ser His Tyr Phe Gln Lys Ala Arg Asp Thr Leu Tyr 
    50                  55                  60                  


Met Val Trp Gly Gln Gly Arg His Met Asp Arg Val Leu Gly Gly Arg 
65                  70                  75                  80  


Thr Tyr Arg Thr Leu Leu Gln Leu Thr Arg Met Tyr Pro Gly Leu Gln 
                85                  90                  95      


Val Tyr Thr Phe Thr Glu Arg Met Met Ala Tyr Cys Asp Gln Ile Phe 
            100                 105                 110         


Gln Asp Glu Thr Gly Lys Asn Arg Arg Gln Ser Gly Ser Phe Leu Ser 
        115                 120                 125             


Thr Gly Trp Phe Thr Met Ile Leu Ala Leu Glu Leu Cys Glu Glu Ile 
    130                 135                 140                 


Val Val Tyr Gly Met Val Ser Asp Ser Tyr Cys Arg Glu Lys Ser His 
145                 150                 155                 160 


Pro Ser Val Pro Tyr His Tyr Phe Glu Lys Gly Arg Leu Asp Glu Cys 
                165                 170                 175     


Gln Met Tyr Leu Ala His Glu Gln Ala Pro Arg Ser Ala His Arg Phe 
            180                 185                 190         


Ile Thr Glu Lys Ala Val Phe Ser Arg Trp Ala Lys Lys Arg Pro Ile 
        195                 200                 205             


Val Phe Ala His Pro Ser Trp Arg Thr Glu 
    210                 215             


<210>  6438
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  6438

Met Met Leu Arg Phe Ser Met Cys Arg Gly Asn Asp Glu Gly Phe Ala 
1               5                   10                  15      


Met Glu Gln Ile Trp Leu Leu Leu Leu Leu Thr Ile Arg Val Leu Pro 
            20                  25                  30          


Gly Ser Ala Gln Phe Asn Gly Tyr Asn Cys Asp Ala Asn Leu His Ser 
        35                  40                  45              


Arg Phe Pro Ala Glu Arg Asp Ile Ser Val Tyr Cys Gly Val Gln Ala 
    50                  55                  60                  


Ile Thr Met Lys Ile Asn Phe Cys Thr Val Leu Phe Ser Gly Tyr Ser 
65                  70                  75                  80  


Glu Thr Asp Leu Ala Leu Asn Gly Arg His Gly Asp Ser His Cys Arg 
                85                  90                  95      


Gly Phe Ile Asn Asn Asn Thr Phe Pro Ala Val Val Ile Phe Ile Ile 
            100                 105                 110         


Asn Leu Ser Thr Leu Glu Gly Cys Gly Asn Asn Leu Val Val Ser Thr 
        115                 120                 125             


Ile Pro Gly Val Ser Ala Tyr Gly Asn Ala Thr Ser Val Gln Val Gly 
    130                 135                 140                 


Asn Ile Ser Gly Tyr Ile Asp Thr Pro Asp Pro Pro Thr Ile Ile Ser 
145                 150                 155                 160 


Tyr Leu Pro Gly Leu Leu Tyr Lys Phe Ser Cys Ser Tyr Pro Leu Glu 
                165                 170                 175     


Tyr Leu Val Asn Asn Thr Gln Leu Ala Ser Ser Ser Ala Ala Ile Ser 
            180                 185                 190         


Val Arg Glu Asn Asn Gly Thr Phe Val Ser Thr Leu Asn Leu Leu Leu 
        195                 200                 205             


Tyr Asn Asp Ser Thr Tyr Asn Gln Gln Leu Ile Ile Pro Ser Ile Gly 
    210                 215                 220                 


Leu Pro Leu Lys Thr Lys Val Phe Ala Ala Val Gln Ala Thr Asn Leu 
225                 230                 235                 240 


Asp Gly Arg Trp Asn Val Leu Met Asp Tyr Cys Tyr Thr Thr Pro Ser 
                245                 250                 255     


Gly Asn Pro Asn Asp Asp Ile Arg Tyr Asp Leu Phe Leu Ser Cys Asp 
            260                 265                 270         


Lys Asp Pro Gln Thr Thr Val Ile Glu Asn Gly Arg Ser Gln Arg Gly 
        275                 280                 285             


Arg Phe Ser Phe Glu Val Phe Arg Phe Val Lys His Lys Asn Gln Lys 
    290                 295                 300                 


Met Ser Thr Val Phe Leu His Cys Val Thr Lys Leu Cys Arg Ala Asp 
305                 310                 315                 320 


Asp Cys Pro Phe Leu Met Pro Ile Cys Ser His Arg Glu Arg Arg Asp 
                325                 330                 335     


Ala Gly Arg Arg Thr Thr Trp Ser Pro Gln Ser Ser Ser Gly Ser Ala 
            340                 345                 350         


Val Leu Ser Ala Gly Pro Ile Ile Thr Arg Ser Asp Glu Thr Pro Thr 
        355                 360                 365             


Asn Asn Ser Gln Leu Gly Ser Pro Ser Met Pro Pro Phe Gln Leu Asn 
    370                 375                 380                 


Ala Ile Thr Ser Ala Leu Ile Ser Gly Met Val Ile Leu Gly Val Thr 
385                 390                 395                 400 


Ser Phe Ser Leu Leu Leu Cys Ser Leu Ala Leu Leu His Arg Lys Gly 
                405                 410                 415     


Pro Thr Ser Leu Val Leu Asn Gly Ile Arg Asn Pro Val Phe Asp 
            420                 425                 430     


<210>  6439
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  6439

Met Val Asn Asn Phe Ser Gln Ala Glu Ala Val Glu Leu Cys Tyr Lys 
1               5                   10                  15      


Asn Val Asn Glu Ser Cys Ile Lys Thr Pro Tyr Ser Pro Gly Pro Arg 
            20                  25                  30          


Ser Ile Leu Tyr Ala Val Leu Gly Phe Gly Ala Val Leu Ala Ala Phe 
        35                  40                  45              


Gly Asn Leu Leu Val Met Ile Ala Ile Leu His Phe Lys Gln Leu His 
    50                  55                  60                  


Thr Pro Thr Asn Phe Leu Ile Ala Ser Leu Ala Cys Ala Asp Phe Leu 
65                  70                  75                  80  


Val Gly Val Thr Val Met Pro Phe Ser Thr Val Arg Ser Val Glu Ser 
                85                  90                  95      


Cys Trp Tyr Phe Gly Asp Ser Tyr Cys Lys Phe His Thr Cys Phe Asp 
            100                 105                 110         


Thr Ser Phe Cys Phe Ala Ser Leu Phe His Leu Cys Cys Ile Ser Val 
        115                 120                 125             


Asp Arg Tyr Ile Ala Val Thr Asp Pro Leu Thr Tyr Pro Thr Lys Phe 
    130                 135                 140                 


Thr Val Ser Val Ser Gly Ile Cys Ile Val Leu Ser Trp Phe Phe Ser 
145                 150                 155                 160 


Val Thr Tyr Ser Phe Ser Ile Phe Tyr Thr Gly Ala Asn Glu Glu Gly 
                165                 170                 175     


Ile Glu Glu Leu Val Val Ala Leu Thr Cys Val Gly Gly Cys Gln Ala 
            180                 185                 190         


Pro Leu Asn Gln Asn Trp Val Leu Leu Cys Phe Leu Leu Phe Phe Ile 
        195                 200                 205             


Pro Asn Val Ala Met Val Phe Ile Tyr Ser Lys Ile Phe Leu Val Ala 
    210                 215                 220                 


Lys His Gln Ala Arg Lys Ile Glu Ser Thr Ala Ser Gln Ala Gln Ser 
225                 230                 235                 240 


Ser Ser Glu Ser Tyr Lys Glu Arg Val Ala Lys Arg Glu Arg Lys Ala 
                245                 250                 255     


Ala Lys Thr Leu Gly Ile Ala Met Ala Ala Phe Leu Val Ser Trp Leu 
            260                 265                 270         


Pro Tyr Leu Val Asp Ala Val Ile Asp Ala Tyr Met Asn Phe Ile Thr 
        275                 280                 285             


Pro Pro Tyr Val Tyr Glu Ile Leu Val Trp Cys Val Tyr Tyr Asn Ser 
    290                 295                 300                 


Ala Met Asn Pro Leu Ile Tyr Ala Phe Phe Tyr Gln Trp Phe Gly Lys 
305                 310                 315                 320 


Ala Ile Lys Leu Ile Val Ser Gly Lys Val Leu Arg Thr Asp Ser Ser 
                325                 330                 335     


Thr Thr Asn Leu Phe Ser Glu Glu Val Glu Thr Asp 
            340                 345             


<210>  6440
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  6440

Met Arg Pro Ala Phe Ala Leu Cys Leu Leu Trp Gln Ala Leu Trp Pro 
1               5                   10                  15      


Gly Pro Gly Gly Gly Glu His Pro Thr Ala Asp Arg Ala Gly Cys Ser 
            20                  25                  30          


Ala Ser Gly Ala Cys Tyr Ser Leu His His Ala Thr Met Lys Arg Gln 
        35                  40                  45              


Ala Ala Glu Glu Ala Cys Ile Leu Arg Gly Gly Ala Leu Ser Thr Val 
    50                  55                  60                  


Arg Ala Gly Ala Glu Leu Arg Ala Val Leu Ala Leu Leu Arg Ala Gly 
65                  70                  75                  80  


Pro Gly Pro Gly Gly Gly Ser Lys Asp Leu Leu Phe Trp Val Ala Leu 
                85                  90                  95      


Glu Arg Arg Arg Ser His Cys Thr Leu Glu Asn Glu Pro Leu Arg Gly 
            100                 105                 110         


Phe Ser Trp Leu Ser Ser Asp Pro Gly Gly Leu Glu Ser Asp Thr Leu 
        115                 120                 125             


Gln Trp Val Glu Glu Pro Gln Arg Ser Cys Thr Ala Arg Arg Cys Ala 
    130                 135                 140                 


Val Leu Gln Ala Thr Gly Gly Val Glu Pro Ala Gly Trp Lys Glu Met 
145                 150                 155                 160 


Arg Cys His Leu Arg Ala Asn Gly Tyr Leu Cys Lys Tyr Gln Phe Glu 
                165                 170                 175     


Val Leu Cys Pro Ala Pro Arg Pro Gly Ala Ala Ser Asn Leu Ser Tyr 
            180                 185                 190         


Arg Ala Pro Phe Gln Leu His Ser Ala Ala Leu Asp Phe Ser Pro Pro 
        195                 200                 205             


Gly Thr Glu Val Ser Ala Leu Cys Arg Gly Gln Leu Pro Ile Ser Val 
    210                 215                 220                 


Thr Cys Ile Ala Asp Glu Ile Gly Ala Arg Trp Asp Lys Leu Ser Gly 
225                 230                 235                 240 


Asp Val Leu Cys Pro Cys Pro Gly Arg Tyr Leu Arg Ala Gly Lys Cys 
                245                 250                 255     


Ala Glu Leu Pro Asn Cys Leu Asp Asp Leu Gly Gly Phe Ala Cys Glu 
            260                 265                 270         


Cys Ala Thr Gly Phe Glu Leu Gly Lys Asp Gly Arg Ser Cys Val Thr 
        275                 280                 285             


Ser Gly Glu Gly Gln Pro Thr Leu Gly Gly Thr Gly Val Pro Thr Arg 
    290                 295                 300                 


Arg Pro Pro Ala Thr Ala Thr Ser Pro Val Pro Gln Arg Thr Trp Pro 
305                 310                 315                 320 


Ile Arg Val Asp Glu Lys Leu Gly Glu Thr Pro Leu Val Pro Glu Gln 
                325                 330                 335     


Asp Asn Ser Val Thr Ser Ile Pro Glu Ile Pro Arg Trp Gly Ser Gln 
            340                 345                 350         


Ser Thr Met Ser Thr Leu Gln Met Ser Leu Gln Ala Glu Ser Lys Ala 
        355                 360                 365             


Thr Ile Thr Pro Ser Gly Ser Val Ile Ser Lys Phe Asn Ser Thr Thr 
    370                 375                 380                 


Ser Ser Ala Thr Pro Gln Ala Phe Asp Ser Ser Ser Ala Val Val Phe 
385                 390                 395                 400 


Ile Phe Val Ser Thr Ala Val Val Val Leu Val Ile Leu Thr Met Thr 
                405                 410                 415     


Val Leu Gly Leu Val Lys Leu Cys Phe His Glu Ser Pro Ser Ser Gln 
            420                 425                 430         


Pro Arg Lys Glu Ser Met Gly Pro Pro Gly Leu Glu Ser Asp Pro Glu 
        435                 440                 445             


Pro Ala Ala Leu Gly Ser Ser Ser Ala His Cys Thr Asn Asn Gly Val 
    450                 455                 460                 


Lys Val Gly Asp Cys Asp Leu Arg Asp Arg Ala Glu Gly Ala Leu Leu 
465                 470                 475                 480 


Ala Glu Ser Pro Leu Gly Ser Ser Asp Ala 
                485                 490 


<210>  6441
<211>  397
<212>  PRT
<213>  Homo sapiens

<400>  6441

Met Gly Gln Ala Gly Cys Lys Gly Leu Cys Leu Ser Leu Phe Asp Tyr 
1               5                   10                  15      


Lys Thr Glu Lys Tyr Val Ile Ala Lys Asn Lys Lys Val Gly Leu Leu 
            20                  25                  30          


Tyr Arg Leu Leu Gln Ala Ser Ile Leu Ala Tyr Leu Val Val Trp Val 
        35                  40                  45              


Phe Leu Ile Lys Lys Gly Tyr Gln Asp Val Asp Thr Ser Leu Gln Ser 
    50                  55                  60                  


Ala Val Ile Thr Lys Val Lys Gly Val Ala Phe Thr Asn Thr Ser Asp 
65                  70                  75                  80  


Leu Gly Gln Arg Ile Trp Asp Val Ala Asp Tyr Val Ile Pro Ala Gln 
                85                  90                  95      


Asn Glu Gly Ile Pro Asp Gly Ala Cys Ser Lys Asp Ser Asp Cys His 
            100                 105                 110         


Ala Gly Glu Ala Val Thr Ala Gly Asn Gly Val Lys Thr Gly Arg Cys 
        115                 120                 125             


Leu Arg Arg Glu Asn Leu Ala Arg Gly Thr Cys Glu Ile Phe Ala Trp 
    130                 135                 140                 


Cys Pro Leu Glu Thr Ser Ser Arg Pro Glu Glu Pro Phe Leu Lys Glu 
145                 150                 155                 160 


Ala Glu Asp Phe Thr Ile Phe Ile Lys Asn His Ile Arg Phe Pro Lys 
                165                 170                 175     


Phe Asn Phe Ser Asn Asn Val Met Asp Val Lys Asp Arg Ser Phe Leu 
            180                 185                 190         


Lys Ser Cys His Phe Gly Pro Lys Asn His Tyr Cys Pro Ile Phe Arg 
        195                 200                 205             


Leu Gly Ser Val Ile Arg Trp Ala Gly Ser Asp Phe Gln Asp Ile Ala 
    210                 215                 220                 


Leu Glu Gly Gly Val Ile Gly Ile Asn Ile Glu Trp Asn Cys Asp Leu 
225                 230                 235                 240 


Asp Lys Ala Ala Ser Glu Cys His Pro His Tyr Ser Phe Ser Arg Leu 
                245                 250                 255     


Asp Asn Lys Leu Ser Lys Ser Val Ser Ser Gly Tyr Asn Phe Arg Phe 
            260                 265                 270         


Ala Arg Tyr Tyr Arg Asp Ala Ala Gly Val Glu Phe Arg Thr Leu Met 
        275                 280                 285             


Lys Ala Tyr Gly Ile Arg Phe Asp Val Met Val Asn Gly Lys Gly Ala 
    290                 295                 300                 


Phe Phe Cys Asp Leu Val Leu Ile Tyr Leu Ile Lys Lys Arg Glu Phe 
305                 310                 315                 320 


Tyr Arg Asp Lys Lys Tyr Glu Glu Val Arg Gly Leu Glu Asp Ser Ser 
                325                 330                 335     


Gln Glu Ala Glu Asp Glu Ala Ser Gly Leu Gly Leu Ser Glu Gln Leu 
            340                 345                 350         


Thr Ser Gly Pro Gly Leu Leu Gly Met Pro Glu Gln Gln Glu Leu Gln 
        355                 360                 365             


Glu Pro Pro Glu Ala Lys Arg Gly Ser Ser Ser Gln Lys Gly Asn Gly 
    370                 375                 380                 


Ser Val Cys Pro Gln Leu Leu Glu Pro His Arg Ser Thr 
385                 390                 395         


<210>  6442
<211>  397
<212>  PRT
<213>  Homo sapiens

<400>  6442

Met Gly Gln Ala Gly Cys Lys Gly Leu Cys Leu Ser Leu Phe Asp Tyr 
1               5                   10                  15      


Lys Thr Glu Lys Tyr Val Ile Ala Lys Asn Lys Lys Val Gly Leu Leu 
            20                  25                  30          


Tyr Arg Leu Leu Gln Ala Ser Ile Leu Ala Tyr Leu Val Val Trp Val 
        35                  40                  45              


Phe Leu Ile Lys Lys Gly Tyr Gln Asp Val Asp Thr Ser Leu Gln Ser 
    50                  55                  60                  


Ala Val Ile Thr Lys Val Lys Gly Val Ala Phe Thr Asn Thr Ser Asp 
65                  70                  75                  80  


Leu Gly Gln Arg Ile Trp Asp Val Ala Asp Tyr Val Ile Pro Ala Gln 
                85                  90                  95      


Asn Glu Gly Ile Pro Asp Gly Ala Cys Ser Lys Asp Ser Asp Cys His 
            100                 105                 110         


Ala Gly Glu Ala Val Thr Ala Gly Asn Gly Val Lys Thr Gly Arg Cys 
        115                 120                 125             


Leu Arg Arg Glu Asn Leu Ala Arg Gly Thr Cys Glu Ile Phe Ala Trp 
    130                 135                 140                 


Cys Pro Leu Glu Thr Ser Ser Arg Pro Glu Glu Pro Phe Leu Lys Glu 
145                 150                 155                 160 


Ala Glu Asp Phe Thr Ile Phe Ile Lys Asn His Ile Arg Phe Pro Lys 
                165                 170                 175     


Phe Asn Phe Ser Asn Asn Val Met Asp Val Lys Asp Arg Ser Phe Leu 
            180                 185                 190         


Lys Ser Cys His Phe Gly Pro Lys Asn His Tyr Cys Pro Ile Phe Arg 
        195                 200                 205             


Leu Gly Ser Val Ile Arg Trp Ala Gly Ser Asp Phe Gln Asp Ile Ala 
    210                 215                 220                 


Leu Glu Gly Gly Val Ile Gly Ile Asn Ile Glu Trp Asn Cys Asp Leu 
225                 230                 235                 240 


Asp Lys Ala Ala Ser Glu Cys His Pro His Tyr Ser Phe Ser Arg Leu 
                245                 250                 255     


Asp Asn Lys Leu Ser Lys Ser Val Ser Ser Gly Tyr Asn Phe Arg Phe 
            260                 265                 270         


Ala Arg Tyr Tyr Arg Asp Ala Ala Gly Val Glu Phe Arg Thr Leu Met 
        275                 280                 285             


Lys Ala Tyr Gly Ile Arg Phe Asp Val Met Val Asn Gly Lys Gly Ala 
    290                 295                 300                 


Phe Phe Cys Asp Leu Val Leu Ile Tyr Leu Ile Lys Lys Arg Glu Phe 
305                 310                 315                 320 


Tyr Arg Asp Lys Lys Tyr Glu Glu Val Arg Gly Leu Glu Asp Ser Ser 
                325                 330                 335     


Gln Glu Ala Glu Asp Glu Ala Ser Gly Leu Gly Leu Ser Glu Gln Leu 
            340                 345                 350         


Thr Ser Gly Pro Gly Leu Leu Gly Met Pro Glu Gln Gln Glu Leu Gln 
        355                 360                 365             


Glu Pro Pro Glu Ala Lys Arg Gly Ser Ser Ser Gln Lys Gly Asn Gly 
    370                 375                 380                 


Ser Val Cys Pro Gln Leu Leu Glu Pro His Arg Ser Thr 
385                 390                 395         


<210>  6443
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  6443

Met Glu Ser Trp Trp Gly Leu Pro Cys Leu Ala Phe Leu Cys Phe Leu 
1               5                   10                  15      


Met His Ala Arg Gly Gln Arg Asp Phe Asp Leu Ala Asp Ala Leu Asp 
            20                  25                  30          


Asp Pro Glu Pro Thr Lys Lys Pro Asn Ser Asp Ile Tyr Pro Lys Pro 
        35                  40                  45              


Lys Pro Pro Tyr Tyr Pro Gln Pro Glu Asn Pro Asp Ser Gly Gly Asn 
    50                  55                  60                  


Ile Tyr Pro Arg Pro Lys Pro Arg Pro Gln Pro Gln Pro Gly Asn Ser 
65                  70                  75                  80  


Gly Asn Ser Gly Gly Tyr Phe Asn Asp Val Asp Arg Asp Asp Gly Arg 
                85                  90                  95      


Tyr Pro Pro Arg Pro Arg Pro Arg Pro Pro Ala Gly Gly Gly Gly Gly 
            100                 105                 110         


Gly Tyr Ser Ser Tyr Gly Asn Ser Asp Asn Thr His Gly Gly Asp His 
        115                 120                 125             


His Ser Thr Tyr Gly Asn Pro Glu Gly Asn Met Val Ala Lys Ile Val 
    130                 135                 140                 


Ser Pro Ile Val Ser Val Val Val Val Thr Leu Leu Gly Ala Ala Ala 
145                 150                 155                 160 


Ser Tyr Phe Lys Leu Asn Asn Arg Arg Asn Cys Phe Arg Thr His Glu 
                165                 170                 175     


Pro Glu Asn Val 
            180 


<210>  6444
<211>  576
<212>  PRT
<213>  Homo sapiens

<400>  6444

Met Trp Ala Pro Arg Cys Arg Arg Phe Trp Ser Arg Trp Glu Gln Val 
1               5                   10                  15      


Ala Ala Leu Leu Leu Leu Leu Leu Leu Leu Gly Val Pro Pro Arg Ser 
            20                  25                  30          


Leu Ala Leu Pro Pro Ile Arg Tyr Ser His Ala Gly Ile Cys Pro Asn 
        35                  40                  45              


Asp Met Asn Pro Asn Leu Trp Val Asp Ala Gln Ser Thr Cys Arg Arg 
    50                  55                  60                  


Glu Cys Glu Thr Asp Gln Glu Cys Glu Thr Tyr Glu Lys Cys Cys Pro 
65                  70                  75                  80  


Asn Val Cys Gly Thr Lys Ser Cys Val Ala Ala Arg Tyr Met Asp Val 
                85                  90                  95      


Lys Gly Lys Lys Gly Pro Val Gly Met Pro Lys Glu Ala Thr Cys Asp 
            100                 105                 110         


His Phe Met Cys Leu Gln Gln Gly Ser Glu Cys Asp Ile Trp Asp Gly 
        115                 120                 125             


Gln Pro Val Cys Lys Cys Lys Asp Arg Cys Glu Lys Glu Pro Ser Phe 
    130                 135                 140                 


Thr Cys Ala Ser Asp Gly Leu Thr Tyr Tyr Asn Arg Cys Tyr Met Asp 
145                 150                 155                 160 


Ala Glu Ala Cys Ser Lys Gly Ile Thr Leu Ala Val Val Thr Cys Arg 
                165                 170                 175     


Tyr His Phe Thr Trp Pro Asn Thr Ser Pro Pro Pro Pro Glu Thr Thr 
            180                 185                 190         


Met His Pro Thr Thr Ala Ser Pro Glu Thr Pro Glu Leu Asp Met Ala 
        195                 200                 205             


Ala Pro Ala Leu Leu Asn Asn Pro Val His Gln Ser Val Thr Met Gly 
    210                 215                 220                 


Glu Thr Val Ser Phe Leu Cys Asp Val Val Gly Arg Pro Arg Pro Glu 
225                 230                 235                 240 


Ile Thr Trp Glu Lys Gln Leu Glu Asp Arg Glu Asn Val Val Met Arg 
                245                 250                 255     


Pro Asn His Val Arg Gly Asn Val Val Val Thr Asn Ile Ala Gln Leu 
            260                 265                 270         


Val Ile Tyr Asn Ala Gln Leu Gln Asp Ala Gly Ile Tyr Thr Cys Thr 
        275                 280                 285             


Ala Arg Asn Val Ala Gly Val Leu Arg Ala Asp Phe Pro Leu Ser Val 
    290                 295                 300                 


Val Arg Gly His Gln Ala Ala Ala Thr Ser Glu Ser Ser Pro Asn Gly 
305                 310                 315                 320 


Thr Ala Phe Pro Ala Ala Glu Cys Leu Lys Pro Pro Asp Ser Glu Asp 
                325                 330                 335     


Cys Gly Glu Glu Gln Thr Arg Trp His Phe Asp Ala Gln Ala Asn Asn 
            340                 345                 350         


Cys Leu Thr Phe Thr Phe Gly His Cys His Arg Asn Leu Asn His Phe 
        355                 360                 365             


Glu Thr Tyr Glu Ala Cys Met Leu Ala Cys Met Ser Gly Pro Leu Ala 
    370                 375                 380                 


Ala Cys Ser Leu Pro Ala Leu Gln Gly Pro Cys Lys Ala Tyr Ala Pro 
385                 390                 395                 400 


Arg Trp Ala Tyr Asn Ser Gln Thr Gly Gln Cys Gln Ser Phe Val Tyr 
                405                 410                 415     


Gly Gly Cys Glu Gly Asn Gly Asn Asn Phe Glu Ser Arg Glu Ala Cys 
            420                 425                 430         


Glu Glu Ser Cys Pro Phe Pro Arg Gly Asn Gln Arg Cys Arg Ala Cys 
        435                 440                 445             


Lys Pro Arg Gln Lys Leu Val Thr Ser Phe Cys Arg Ser Asp Phe Val 
    450                 455                 460                 


Ile Leu Gly Arg Val Ser Glu Leu Thr Glu Glu Pro Asp Ser Gly Arg 
465                 470                 475                 480 


Ala Leu Val Thr Val Asp Glu Val Leu Lys Asp Glu Lys Met Gly Leu 
                485                 490                 495     


Lys Phe Leu Gly Gln Glu Pro Leu Glu Val Thr Leu Leu His Val Asp 
            500                 505                 510         


Trp Ala Cys Pro Cys Pro Asn Val Thr Val Ser Glu Met Pro Leu Ile 
        515                 520                 525             


Ile Met Gly Glu Val Asp Gly Gly Met Ala Met Leu Arg Pro Asp Ser 
    530                 535                 540                 


Phe Val Gly Ala Ser Ser Ala Arg Arg Val Arg Lys Leu Arg Glu Val 
545                 550                 555                 560 


Met His Lys Lys Thr Cys Asp Val Leu Lys Glu Phe Leu Gly Leu His 
                565                 570                 575     


<210>  6445
<211>  905
<212>  PRT
<213>  Homo sapiens

<400>  6445

Met Glu His Gly Thr Leu Leu Ala Gln Pro Gly Leu Trp Thr Arg Asp 
1               5                   10                  15      


Thr Ser Trp Ala Leu Leu Tyr Phe Leu Cys Tyr Ile Leu Pro Gln Thr 
            20                  25                  30          


Ala Pro Gln Val Leu Arg Ile Gly Gly Ile Phe Glu Thr Val Glu Asn 
        35                  40                  45              


Glu Pro Val Asn Val Glu Glu Leu Ala Phe Lys Phe Ala Val Thr Ser 
    50                  55                  60                  


Ile Asn Arg Asn Arg Thr Leu Met Pro Asn Thr Thr Leu Thr Tyr Asp 
65                  70                  75                  80  


Ile Gln Arg Ile Asn Leu Phe Asp Ser Phe Glu Ala Ser Arg Arg Ala 
                85                  90                  95      


Cys Asp Gln Leu Ala Leu Gly Val Ala Ala Leu Phe Gly Pro Ser His 
            100                 105                 110         


Ser Ser Ser Val Ser Ala Val Gln Ser Ile Cys Asn Ala Leu Glu Val 
        115                 120                 125             


Pro His Ile Gln Thr Arg Trp Lys His Pro Ser Val Asp Asn Lys Asp 
    130                 135                 140                 


Leu Phe Tyr Ile Asn Leu Tyr Pro Asp Tyr Ala Ala Ile Ser Arg Ala 
145                 150                 155                 160 


Ile Leu Asp Leu Val Leu Tyr Tyr Asn Trp Lys Thr Val Thr Val Val 
                165                 170                 175     


Tyr Glu Asp Ser Thr Gly Leu Ile Arg Leu Gln Glu Leu Ile Lys Ala 
            180                 185                 190         


Pro Ser Arg Tyr Asn Ile Lys Ile Lys Ile Arg Gln Leu Pro Ser Gly 
        195                 200                 205             


Asn Lys Asp Ala Lys Pro Leu Leu Lys Glu Met Lys Lys Gly Lys Glu 
    210                 215                 220                 


Phe Tyr Val Ile Phe Asp Cys Ser His Glu Thr Ala Ala Glu Ile Leu 
225                 230                 235                 240 


Lys Gln Ile Leu Phe Met Gly Met Met Thr Glu Tyr Tyr His Tyr Phe 
                245                 250                 255     


Phe Thr Thr Leu Asp Leu Phe Ala Leu Asp Leu Glu Leu Tyr Arg Tyr 
            260                 265                 270         


Ser Gly Val Asn Met Thr Gly Phe Arg Leu Leu Asn Ile Asp Asn Pro 
        275                 280                 285             


His Val Ser Ser Ile Ile Glu Lys Trp Ser Met Glu Arg Leu Gln Ala 
    290                 295                 300                 


Pro Pro Arg Pro Glu Thr Gly Leu Leu Asp Gly Met Met Thr Thr Glu 
305                 310                 315                 320 


Ala Ala Leu Met Tyr Asp Ala Val Tyr Met Val Ala Ile Ala Ser His 
                325                 330                 335     


Arg Ala Ser Gln Leu Thr Val Ser Ser Leu Gln Cys His Arg His Lys 
            340                 345                 350         


Pro Trp Arg Leu Gly Pro Arg Phe Met Asn Leu Ile Lys Glu Ala Arg 
        355                 360                 365             


Trp Asp Gly Leu Thr Gly His Ile Thr Phe Asn Lys Thr Asn Gly Leu 
    370                 375                 380                 


Arg Lys Asp Phe Asp Leu Asp Ile Ile Ser Leu Lys Glu Glu Gly Thr 
385                 390                 395                 400 


Glu Lys Ile Gly Ile Trp Asn Ser Asn Ser Gly Leu Asn Met Thr Asp 
                405                 410                 415     


Ser Asn Lys Asp Lys Ser Ser Asn Ile Thr Asp Ser Leu Ala Asn Arg 
            420                 425                 430         


Thr Leu Ile Val Thr Thr Ile Leu Glu Glu Pro Tyr Val Met Tyr Arg 
        435                 440                 445             


Lys Ser Asp Lys Pro Leu Tyr Gly Asn Asp Arg Phe Glu Gly Tyr Cys 
    450                 455                 460                 


Leu Asp Leu Leu Lys Glu Leu Ser Asn Ile Leu Gly Phe Ile Tyr Asp 
465                 470                 475                 480 


Val Lys Leu Val Pro Asp Gly Lys Tyr Gly Ala Gln Asn Asp Lys Gly 
                485                 490                 495     


Glu Trp Asn Gly Met Val Lys Glu Leu Ile Asp His Arg Ala Asp Leu 
            500                 505                 510         


Ala Val Ala Pro Leu Thr Ile Thr Tyr Val Arg Glu Lys Val Ile Asp 
        515                 520                 525             


Phe Ser Lys Pro Phe Met Thr Leu Gly Ile Ser Ile Leu Tyr Arg Lys 
    530                 535                 540                 


Pro Asn Gly Thr Asn Pro Gly Val Phe Ser Phe Leu Asn Pro Leu Ser 
545                 550                 555                 560 


Pro Asp Ile Trp Met Tyr Val Leu Leu Ala Cys Leu Gly Val Ser Cys 
                565                 570                 575     


Val Leu Phe Val Ile Ala Arg Phe Thr Pro Tyr Glu Trp Tyr Asn Pro 
            580                 585                 590         


His Pro Cys Asn Pro Asp Ser Asp Val Val Glu Asn Asn Phe Thr Leu 
        595                 600                 605             


Leu Asn Ser Phe Trp Phe Gly Val Gly Ala Leu Met Gln Gln Gly Ser 
    610                 615                 620                 


Glu Leu Met Pro Lys Ala Leu Ser Thr Arg Ile Val Gly Gly Ile Trp 
625                 630                 635                 640 


Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala 
                645                 650                 655     


Ala Phe Leu Thr Val Glu Arg Met Glu Ser Pro Ile Asp Ser Ala Asp 
            660                 665                 670         


Asp Leu Ala Lys Gln Thr Lys Ile Glu Tyr Gly Ala Val Arg Asp Gly 
        675                 680                 685             


Ser Thr Met Thr Phe Phe Lys Lys Ser Lys Ile Ser Thr Tyr Glu Lys 
    690                 695                 700                 


Met Trp Ala Phe Met Ser Ser Arg Gln Gln Thr Ala Leu Val Arg Asn 
705                 710                 715                 720 


Ser Asp Glu Gly Ile Gln Arg Val Leu Thr Thr Asp Tyr Ala Leu Leu 
                725                 730                 735     


Met Glu Ser Thr Ser Ile Glu Tyr Val Thr Gln Arg Asn Cys Asn Leu 
            740                 745                 750         


Thr Gln Ile Gly Gly Leu Ile Asp Ser Lys Gly Tyr Gly Val Gly Thr 
        755                 760                 765             


Pro Ile Gly Ser Pro Tyr Arg Asp Lys Ile Thr Ile Ala Ile Leu Gln 
    770                 775                 780                 


Leu Gln Glu Glu Gly Lys Leu His Met Met Lys Glu Lys Trp Trp Arg 
785                 790                 795                 800 


Gly Asn Gly Cys Pro Glu Glu Asp Asn Lys Glu Ala Ser Ala Leu Gly 
                805                 810                 815     


Val Glu Asn Ile Gly Gly Ile Phe Ile Val Leu Ala Ala Gly Leu Val 
            820                 825                 830         


Leu Ser Val Phe Val Ala Ile Gly Glu Phe Ile Tyr Lys Ser Arg Lys 
        835                 840                 845             


Asn Asn Asp Ile Glu Gln Cys Leu Ser Phe Asn Ala Ile Met Glu Glu 
    850                 855                 860                 


Leu Gly Ile Ser Leu Lys Asn Gln Lys Lys Ile Lys Lys Lys Ser Arg 
865                 870                 875                 880 


Thr Lys Gly Lys Ser Ser Phe Thr Ser Ile Leu Thr Cys His Gln Arg 
                885                 890                 895     


Arg Thr Gln Arg Lys Glu Thr Val Ala 
            900                 905 


<210>  6446
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be any naturally occurring amino acid

<400>  6446

Ala Leu Pro His Ala Ser Asx Cys Met Pro Leu Glu Xaa Ser Asx Asn 
1               5                   10                  15      


Ile Thr Ile Ser Phe Arg Met His Met Ser Ala Pro Ile Glu Asn Ser 
            20                  25                  30          


<210>  6447
<211>  876
<212>  PRT
<213>  Homo sapiens

<400>  6447

Met Arg Ala Leu Ala Val Leu Ser Val Thr Leu Val Met Ala Cys Thr 
1               5                   10                  15      


Glu Ala Phe Phe Pro Phe Ile Ser Arg Gly Lys Glu Leu Leu Trp Gly 
            20                  25                  30          


Lys Pro Glu Glu Ser Arg Val Ser Ser Val Leu Glu Glu Ser Lys Arg 
        35                  40                  45              


Leu Val Asp Thr Ala Met Tyr Ala Thr Met Gln Arg Asn Leu Lys Lys 
    50                  55                  60                  


Arg Gly Ile Leu Ser Pro Ala Gln Leu Leu Ser Phe Ser Lys Leu Pro 
65                  70                  75                  80  


Glu Pro Thr Ser Gly Val Ile Ala Arg Ala Ala Glu Ile Met Glu Thr 
                85                  90                  95      


Ser Ile Gln Ala Met Lys Arg Lys Val Asn Leu Lys Thr Gln Gln Ser 
            100                 105                 110         


Gln His Pro Thr Asp Ala Leu Ser Glu Asp Leu Leu Ser Ile Ile Ala 
        115                 120                 125             


Asn Met Ser Gly Cys Leu Pro Tyr Met Leu Pro Pro Lys Cys Pro Asn 
    130                 135                 140                 


Thr Cys Leu Ala Asn Lys Tyr Arg Pro Ile Thr Gly Ala Cys Asn Asn 
145                 150                 155                 160 


Arg Asp His Pro Arg Trp Gly Ala Ser Asn Thr Ala Leu Ala Arg Trp 
                165                 170                 175     


Leu Pro Pro Val Tyr Glu Asp Gly Phe Ser Gln Pro Arg Gly Trp Asn 
            180                 185                 190         


Pro Gly Phe Leu Tyr Asn Gly Phe Pro Leu Pro Pro Val Arg Glu Val 
        195                 200                 205             


Thr Arg His Val Ile Gln Val Ser Asn Glu Val Val Thr Asp Asp Asp 
    210                 215                 220                 


Arg Tyr Ser Asp Leu Leu Met Ala Trp Gly Gln Tyr Ile Asp His Asp 
225                 230                 235                 240 


Ile Ala Phe Thr Pro Gln Ser Thr Ser Lys Ala Ala Phe Gly Gly Gly 
                245                 250                 255     


Ala Asp Cys Gln Met Thr Cys Glu Asn Gln Asn Pro Cys Phe Pro Ile 
            260                 265                 270         


Gln Leu Pro Glu Glu Ala Arg Pro Ala Ala Gly Thr Ala Cys Leu Pro 
        275                 280                 285             


Phe Tyr Arg Ser Ser Ala Ala Cys Gly Thr Gly Asp Gln Gly Ala Leu 
    290                 295                 300                 


Phe Gly Asn Leu Ser Thr Ala Asn Pro Arg Gln Gln Met Asn Gly Leu 
305                 310                 315                 320 


Thr Ser Phe Leu Asp Ala Ser Thr Val Tyr Gly Ser Ser Pro Ala Leu 
                325                 330                 335     


Glu Arg Gln Leu Arg Asn Trp Thr Ser Ala Glu Gly Leu Leu Arg Val 
            340                 345                 350         


His Ala Arg Leu Arg Asp Ser Gly Arg Ala Tyr Leu Pro Phe Val Pro 
        355                 360                 365             


Pro Arg Ala Pro Ala Ala Cys Ala Pro Glu Pro Gly Ile Pro Gly Glu 
    370                 375                 380                 


Thr Arg Gly Pro Cys Phe Leu Ala Gly Asp Gly Arg Ala Ser Glu Val 
385                 390                 395                 400 


Pro Ser Leu Thr Ala Leu His Thr Leu Trp Leu Arg Glu His Asn Arg 
                405                 410                 415     


Leu Ala Ala Ala Leu Lys Ala Leu Asn Ala His Trp Ser Ala Asp Ala 
            420                 425                 430         


Val Tyr Gln Glu Ala Arg Lys Val Val Gly Ala Leu His Gln Ile Ile 
        435                 440                 445             


Thr Leu Arg Asp Tyr Ile Pro Arg Ile Leu Gly Pro Glu Ala Phe Gln 
    450                 455                 460                 


Gln Tyr Val Gly Pro Tyr Glu Gly Tyr Asp Ser Thr Ala Asn Pro Thr 
465                 470                 475                 480 


Val Ser Asn Val Phe Ser Thr Ala Ala Phe Arg Phe Gly His Ala Thr 
                485                 490                 495     


Ile His Pro Leu Val Arg Arg Leu Asp Ala Ser Phe Gln Glu His Pro 
            500                 505                 510         


Asp Leu Pro Gly Leu Trp Leu His Gln Ala Phe Phe Ser Pro Trp Thr 
        515                 520                 525             


Leu Leu Arg Gly Gly Tyr Asn Glu Trp Arg Glu Phe Cys Gly Leu Pro 
    530                 535                 540                 


Arg Leu Glu Thr Pro Ala Asp Leu Ser Thr Ala Ile Ala Ser Arg Ser 
545                 550                 555                 560 


Val Ala Asp Lys Ile Leu Asp Leu Tyr Lys His Pro Asp Asn Ile Asp 
                565                 570                 575     


Val Trp Leu Gly Gly Leu Ala Glu Asn Phe Leu Pro Arg Ala Arg Thr 
            580                 585                 590         


Gly Pro Leu Phe Ala Cys Leu Ile Gly Lys Gln Met Lys Ala Leu Arg 
        595                 600                 605             


Asp Gly Asp Trp Phe Trp Trp Glu Asn Ser His Val Phe Thr Asp Ala 
    610                 615                 620                 


Gln Arg Arg Glu Leu Glu Lys His Ser Leu Ser Arg Val Ile Cys Asp 
625                 630                 635                 640 


Asn Thr Gly Leu Thr Arg Val Pro Met Asp Ala Phe Gln Val Gly Lys 
                645                 650                 655     


Phe Pro Glu Asp Phe Glu Ser Cys Asp Ser Ile Thr Gly Met Asn Leu 
            660                 665                 670         


Glu Ala Trp Arg Glu Thr Phe Pro Gln Asp Asp Lys Cys Gly Phe Pro 
        675                 680                 685             


Glu Ser Val Glu Asn Gly Asp Phe Val His Cys Glu Glu Ser Gly Arg 
    690                 695                 700                 


Arg Val Leu Val Tyr Ser Cys Arg His Gly Tyr Glu Leu Gln Gly Arg 
705                 710                 715                 720 


Glu Gln Leu Thr Cys Thr Gln Glu Gly Trp Asp Phe Gln Pro Pro Leu 
                725                 730                 735     


Cys Lys Asp Val Asn Glu Cys Ala Asp Gly Ala His Pro Pro Cys His 
            740                 745                 750         


Ala Ser Ala Arg Cys Arg Asn Thr Lys Gly Gly Phe Gln Cys Leu Cys 
        755                 760                 765             


Ala Asp Pro Tyr Glu Leu Gly Asp Asp Gly Arg Thr Cys Val Asp Ser 
    770                 775                 780                 


Gly Arg Leu Pro Arg Val Thr Trp Ile Ser Met Ser Leu Ala Ala Leu 
785                 790                 795                 800 


Leu Ile Gly Gly Phe Ala Gly Leu Thr Ser Thr Val Ile Cys Arg Trp 
                805                 810                 815     


Thr Arg Thr Gly Thr Lys Ser Thr Leu Pro Ile Ser Glu Thr Gly Gly 
            820                 825                 830         


Gly Thr Pro Glu Leu Arg Cys Gly Lys His Gln Ala Val Gly Thr Ser 
        835                 840                 845             


Pro Gln Arg Ala Ala Ala Gln Asp Ser Glu Gln Glu Ser Ala Gly Met 
    850                 855                 860                 


Glu Gly Arg Asp Thr His Arg Leu Pro Arg Ala Leu 
865                 870                 875     


<210>  6448
<211>  889
<212>  PRT
<213>  Homo sapiens

<400>  6448

Met Arg Ala Leu Ala Val Leu Ser Val Thr Leu Val Met Ala Cys Thr 
1               5                   10                  15      


Glu Ala Phe Phe Pro Phe Ile Ser Arg Gly Lys Glu Leu Leu Trp Gly 
            20                  25                  30          


Lys Pro Glu Glu Ser Arg Val Ser Ser Val Leu Glu Glu Ser Lys Arg 
        35                  40                  45              


Leu Val Asp Thr Ala Met Tyr Ala Thr Met Gln Arg Asn Leu Lys Lys 
    50                  55                  60                  


Arg Gly Ile Leu Ser Pro Ala Gln Leu Leu Ser Phe Ser Lys Leu Pro 
65                  70                  75                  80  


Glu Pro Thr Ser Gly Val Ile Ala Arg Ala Ala Glu Ile Met Glu Thr 
                85                  90                  95      


Ser Ile Gln Ala Met Lys Arg Lys Val Asn Leu Lys Thr Gln Gln Ser 
            100                 105                 110         


Gln His Pro Thr Asp Ala Leu Ser Glu Asp Leu Leu Ser Ile Ile Ala 
        115                 120                 125             


Asn Met Ser Gly Cys Leu Pro Tyr Met Leu Pro Pro Lys Cys Pro Asn 
    130                 135                 140                 


Thr Cys Leu Ala Asn Lys Tyr Arg Pro Ile Thr Gly Ala Cys Asn Asn 
145                 150                 155                 160 


Arg Asp His Pro Arg Trp Gly Ala Ser Asn Thr Ala Leu Ala Arg Trp 
                165                 170                 175     


Leu Pro Pro Val Tyr Glu Asp Gly Phe Ser Gln Pro Arg Gly Trp Asn 
            180                 185                 190         


Pro Gly Phe Leu Tyr Asn Gly Phe Pro Leu Pro Pro Val Arg Glu Val 
        195                 200                 205             


Thr Arg His Val Ile Gln Val Ser Asn Glu Val Val Thr Asp Asp Asp 
    210                 215                 220                 


Arg Tyr Ser Asp Leu Leu Met Ala Trp Gly Gln Tyr Ile Asp His Asp 
225                 230                 235                 240 


Ile Ala Phe Thr Pro Gln Ser Thr Ser Lys Ala Ala Phe Gly Gly Gly 
                245                 250                 255     


Ala Asp Cys Gln Met Thr Cys Glu Asn Gln Asn Pro Cys Phe Pro Ile 
            260                 265                 270         


Gln Leu Pro Glu Glu Ala Arg Pro Ala Ala Gly Thr Ala Cys Leu Pro 
        275                 280                 285             


Phe Tyr Arg Ser Ser Ala Ala Cys Gly Thr Gly Asp Gln Gly Ala Leu 
    290                 295                 300                 


Phe Gly Asn Leu Ser Thr Ala Asn Pro Arg Gln Gln Met Asn Gly Leu 
305                 310                 315                 320 


Thr Ser Phe Leu Asp Ala Ser Thr Val Tyr Gly Ser Ser Pro Ala Leu 
                325                 330                 335     


Glu Arg Gln Leu Arg Asn Trp Thr Ser Ala Glu Gly Leu Leu Arg Val 
            340                 345                 350         


His Ala Arg Leu Arg Asp Ser Gly Arg Ala Tyr Leu Pro Phe Val Pro 
        355                 360                 365             


Pro Arg Ala Pro Ala Ala Cys Ala Pro Glu Pro Gly Ile Pro Gly Glu 
    370                 375                 380                 


Thr Arg Gly Pro Cys Phe Leu Ala Gly Asp Gly Arg Ala Ser Glu Val 
385                 390                 395                 400 


Pro Ser Leu Thr Ala Leu His Thr Leu Trp Leu Arg Glu His Asn Arg 
                405                 410                 415     


Leu Ala Ala Ala Leu Lys Ala Leu Asn Ala His Trp Ser Ala Asp Ala 
            420                 425                 430         


Val Tyr Gln Glu Ala Arg Lys Val Val Gly Ala Leu His Gln Ile Ile 
        435                 440                 445             


Thr Leu Arg Asp Tyr Ile Pro Arg Ile Leu Gly Pro Glu Ala Phe Gln 
    450                 455                 460                 


Gln Tyr Val Gly Pro Tyr Glu Gly Tyr Asp Ser Thr Ala Asn Pro Thr 
465                 470                 475                 480 


Val Ser Asn Val Phe Ser Thr Ala Ala Phe Arg Phe Gly His Ala Thr 
                485                 490                 495     


Ile His Pro Leu Val Arg Arg Leu Asp Ala Ser Phe Gln Glu His Pro 
            500                 505                 510         


Asp Leu Pro Gly Leu Trp Leu His Gln Ala Phe Phe Ser Pro Trp Thr 
        515                 520                 525             


Leu Leu Arg Gly Gly Gly Leu Asp Pro Leu Ile Arg Gly Leu Leu Ala 
    530                 535                 540                 


Arg Pro Ala Lys Leu Gln Val Gln Asp Gln Leu Met Asn Glu Glu Leu 
545                 550                 555                 560 


Thr Glu Arg Leu Phe Val Leu Ser Asn Ser Ser Thr Leu Asp Leu Ala 
                565                 570                 575     


Ser Ile Asn Leu Gln Arg Gly Arg Asp His Gly Leu Pro Gly Tyr Asn 
            580                 585                 590         


Glu Trp Arg Glu Phe Cys Gly Leu Pro Arg Leu Glu Thr Pro Ala Asp 
        595                 600                 605             


Leu Ser Thr Ala Ile Ala Ser Arg Ser Val Ala Asp Lys Ile Leu Asp 
    610                 615                 620                 


Leu Tyr Lys His Pro Asp Asn Ile Asp Val Trp Leu Gly Gly Leu Ala 
625                 630                 635                 640 


Glu Asn Phe Leu Pro Arg Ala Arg Thr Gly Pro Leu Phe Ala Cys Leu 
                645                 650                 655     


Ile Gly Lys Gln Met Lys Ala Leu Arg Asp Gly Asp Trp Phe Trp Trp 
            660                 665                 670         


Glu Asn Ser His Val Phe Thr Asp Ala Gln Arg Arg Glu Leu Glu Lys 
        675                 680                 685             


His Ser Leu Ser Arg Val Ile Cys Asp Asn Thr Gly Leu Thr Arg Val 
    690                 695                 700                 


Pro Met Asp Ala Phe Gln Val Gly Lys Phe Pro Glu Asp Phe Glu Ser 
705                 710                 715                 720 


Cys Asp Ser Ile Thr Gly Met Asn Leu Glu Ala Trp Arg Glu Thr Phe 
                725                 730                 735     


Pro Gln Asp Asp Lys Cys Gly Phe Pro Glu Ser Val Glu Asn Gly Asp 
            740                 745                 750         


Phe Val His Cys Glu Glu Ser Gly Arg Arg Val Leu Val Tyr Ser Cys 
        755                 760                 765             


Arg His Gly Tyr Glu Leu Gln Gly Arg Glu Gln Leu Thr Cys Thr Gln 
    770                 775                 780                 


Glu Gly Trp Asp Phe Gln Pro Pro Leu Cys Lys Asp Ser Gly Arg Leu 
785                 790                 795                 800 


Pro Arg Val Thr Trp Ile Ser Met Ser Leu Ala Ala Leu Leu Ile Gly 
                805                 810                 815     


Gly Phe Ala Gly Leu Thr Ser Thr Val Ile Cys Arg Trp Thr Arg Thr 
            820                 825                 830         


Gly Thr Lys Ser Thr Leu Pro Ile Ser Glu Thr Gly Gly Gly Thr Pro 
        835                 840                 845             


Glu Leu Arg Cys Gly Lys His Gln Ala Val Gly Thr Ser Pro Gln Arg 
    850                 855                 860                 


Ala Ala Ala Gln Asp Ser Glu Gln Glu Ser Ala Gly Met Glu Gly Arg 
865                 870                 875                 880 


Asp Thr His Arg Leu Pro Arg Ala Leu 
                885                 


<210>  6449
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  6449

Met Arg Ala Leu Ala Val Leu Ser Val Thr Leu Val Met Ala Cys Thr 
1               5                   10                  15      


Glu Ala Phe Phe Pro Phe Ile Ser Arg Gly Lys Glu Leu Leu Trp Gly 
            20                  25                  30          


Lys Pro Glu Glu Ser Arg Val Ser Ser Val Leu Glu Glu Ser Lys Arg 
        35                  40                  45              


Leu Val Asp Thr Ala Met Tyr Ala Thr Met Gln Arg Asn Leu Lys Lys 
    50                  55                  60                  


Arg Gly Ile Leu Ser Pro Ala Gln Leu Leu Ser Phe Ser Lys Leu Pro 
65                  70                  75                  80  


Glu Pro Thr Ser Gly Val Ile Ala Arg Ala Ala Glu Ile Met Glu Thr 
                85                  90                  95      


Ser Ile Gln Ala Met Lys Arg Lys Val Asn Leu Lys Thr Gln Gln Ser 
            100                 105                 110         


Gln His Pro Thr Asp Ala Leu Ser Glu Asp Leu Leu Ser Ile Ile Ala 
        115                 120                 125             


Asn Met Ser Gly Cys Leu Pro Tyr Met Leu Pro Pro Lys Cys Pro Asn 
    130                 135                 140                 


Thr Cys Leu Ala Asn Lys Tyr Arg Pro Ile Thr Gly Ala Cys Asn Asn 
145                 150                 155                 160 


Arg Asp His Pro Arg Trp Gly Ala Ser Asn Thr Ala Leu Ala Arg Trp 
                165                 170                 175     


Leu Pro Pro Val Tyr Glu Asp Gly Phe Ser Gln Pro Arg Gly Trp Asn 
            180                 185                 190         


Pro Gly Phe Leu Tyr Asn Gly Phe Pro Leu Pro Pro Val Arg Glu Val 
        195                 200                 205             


Thr Arg His Val Ile Gln Val Ser Asn Glu Val Val Thr Asp Asp Asp 
    210                 215                 220                 


Arg Tyr Ser Asp Leu Leu Met Ala Trp Gly Gln Tyr Ile Asp His Asp 
225                 230                 235                 240 


Ile Ala Phe Thr Pro Gln Ser Thr Ser Lys Ala Ala Phe Gly Gly Gly 
                245                 250                 255     


Ala Asp Cys Gln Met Thr Cys Glu Asn Gln Asn Pro Cys Phe Pro Ile 
            260                 265                 270         


Gln Ile Ile Thr Leu Arg Asp Tyr Ile Pro Arg Ile Leu Gly Pro Glu 
        275                 280                 285             


Ala Phe Gln Gln Tyr Val Gly Pro Tyr Glu Gly Tyr Asp Ser Thr Ala 
    290                 295                 300                 


Asn Pro Thr Val Ser Asn Val Phe Ser Thr Ala Ala Phe Arg Phe Gly 
305                 310                 315                 320 


His Ala Thr Ile His Pro Leu Val Arg Arg Leu Asp Ala Ser Phe Gln 
                325                 330                 335     


Glu His Pro Asp Leu Pro Gly Leu Trp Leu His Gln Ala Phe Phe Ser 
            340                 345                 350         


Pro Trp Thr Leu Leu Arg Gly Gly Gly Leu Asp Pro Leu Ile Arg Gly 
        355                 360                 365             


Leu Leu Ala Arg Pro Ala Lys Leu Gln Val Gln Asp Gln Leu Met Asn 
    370                 375                 380                 


Glu Glu Leu Thr Glu Arg Leu Phe Val Leu Ser Asn Ser Ser Thr Leu 
385                 390                 395                 400 


Asp Leu Ala Ser Ile Asn Leu Gln Arg Gly Arg Asp His Gly Leu Pro 
                405                 410                 415     


Gly Tyr Asn Glu Trp Arg Glu Phe Cys Gly Leu Pro Arg Leu Glu Thr 
            420                 425                 430         


Pro Ala Asp Leu Ser Thr Ala Ile Ala Ser Arg Ser Val Ala Asp Lys 
        435                 440                 445             


Ile Leu Asp Leu Tyr Lys His Pro Asp Asn Ile Asp Val Trp Leu Gly 
    450                 455                 460                 


Gly Leu Ala Glu Asn Phe Leu Pro Arg Ala Arg Thr Gly Pro Leu Phe 
465                 470                 475                 480 


Ala Cys Leu Ile Gly Lys Gln Met Lys Ala Leu Arg Asp Gly Asp Trp 
                485                 490                 495     


Phe Trp Trp Glu Asn Ser His Val Phe Thr Asp Ala Gln Arg Arg Glu 
            500                 505                 510         


Leu Glu Lys His Ser Leu Ser Arg Val Ile Cys Asp Asn Thr Gly Leu 
        515                 520                 525             


Thr Arg Val Pro Met Asp Ala Phe Gln Val Gly Lys Phe Pro Glu Asp 
    530                 535                 540                 


Phe Glu Ser Cys Asp Ser Ile Thr Gly Met Asn Leu Glu Ala Trp Arg 
545                 550                 555                 560 


Glu Thr Phe Pro Gln Asp Asp Lys Cys Gly Phe Pro Glu Ser Val Glu 
                565                 570                 575     


Asn Gly Asp Phe Val His Cys Glu Glu Ser Gly Arg Arg Val Leu Val 
            580                 585                 590         


Tyr Ser Cys Arg His Gly Tyr Glu Leu Gln Gly Arg Glu Gln Leu Thr 
        595                 600                 605             


Cys Thr Gln Glu Gly Trp Asp Phe Gln Pro Pro Leu Cys Lys Asp Val 
    610                 615                 620                 


Asn Glu Cys Ala Asp Gly Ala His Pro Pro Cys His Ala Ser Ala Arg 
625                 630                 635                 640 


Cys Arg Asn Thr Lys Gly Gly Phe Gln Cys Leu Cys Ala Asp Pro Tyr 
                645                 650                 655     


Glu Leu Gly Asp Asp Gly Arg Thr Cys Val Asp Ser Gly Arg Leu Pro 
            660                 665                 670         


Arg Val Thr Trp Ile Ser Met Ser Leu Ala Ala Leu Leu Ile Gly Gly 
        675                 680                 685             


Phe Ala Gly Leu Thr Ser Thr Val Ile Cys Arg Trp Thr Arg Thr Gly 
    690                 695                 700                 


Thr Lys Ser Thr Leu Pro Ile Ser Glu Thr Gly Gly Gly Thr Pro Glu 
705                 710                 715                 720 


Leu Arg Cys Gly Lys His Gln Ala Val Gly Thr Ser Pro Gln Arg Ala 
                725                 730                 735     


Ala Ala Gln Asp Ser Glu Gln Glu Ser Ala Gly Met Glu Gly Arg Asp 
            740                 745                 750         


Thr His Arg Leu Pro Arg Ala Leu 
        755                 760 


<210>  6450
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  6450

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Lys 
                325                 330             


<210>  6451
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  6451

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Phe Ser Arg 
                325                 330                 335 


<210>  6452
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  6452

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Asn Asp Glu His 
                325                 330                 335     


Lys Pro Leu Arg Glu Trp Phe Val Ile Val Ile Met Ala Thr Ile Cys 
            340                 345                 350         


Phe Ile Leu Leu Ile Leu Ser Leu Ile Cys Lys Ile Cys His Leu Trp 
        355                 360                 365             


Ile Lys Leu Phe Pro Pro Ile Pro Ala Pro Lys Ser Asn Ile Lys Asp 
    370                 375                 380                 


Leu Phe Val Thr Thr Asn Tyr Glu Lys Ala Gly Ser Ser Glu Thr Glu 
385                 390                 395                 400 


Ile Glu Val Ile Cys Tyr Ile Glu Lys Pro Gly Val Glu Thr Leu Glu 
                405                 410                 415     


Asp Ser Val Phe 
            420 


<210>  6453
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  6453

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Lys 
                325                 330             


<210>  6454
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  6454

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Phe Ser Arg 
                325                 330                 335 


<210>  6455
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  6455

Met Pro Gly Ala Arg Asp Ala Leu Cys His Gln Ala Leu Gln Leu Leu 
1               5                   10                  15      


Ala Glu Leu Cys Ala Arg Gly Ala Leu Glu His Asp Ser Cys Gln Asp 
            20                  25                  30          


Phe Ile Tyr His Leu Arg Asp Arg Ala Arg Pro Arg Leu Arg Asp Pro 
        35                  40                  45              


Asp Ile Ser Val Ser Leu Leu Thr Leu Val Val Thr Ala Cys Gly Leu 
    50                  55                  60                  


Ala Leu Phe Gly Val Ser Leu Phe Val Ser Trp Lys Leu Cys Trp Val 
65                  70                  75                  80  


Pro Trp Arg Glu Arg Gly Leu Pro Ser Gly Ser Lys Asp Asn Asn Gln 
                85                  90                  95      


Glu Pro Leu Asn Tyr Met Asp Thr Glu Thr Asn Glu Gln Glu Asn Ser 
            100                 105                 110         


Glu Asp Phe Leu Asp Pro Pro Thr Pro Cys Pro Asp Ser Ser Met Lys 
        115                 120                 125             


Ile Ser His Thr Ser Pro Asp Ile Pro Leu Ser Thr Gln Thr Gly Ile 
    130                 135                 140                 


Gln Glu Asn Cys Ala His Gly Val Arg Val Gln Arg Gln Val Thr Glu 
145                 150                 155                 160 


Pro Thr Ser Ser Ala Arg His Asn Ser Ile Arg Arg Gln Leu Asn Leu 
                165                 170                 175     


Ser Asn Pro Asp Phe Asn Ile Gln Gln Leu Gln Lys Gln Glu Gln Leu 
            180                 185                 190         


Thr Gly Ile Gly Arg Ile Lys Pro Glu Leu Tyr Lys Gln Arg Ser Leu 
        195                 200                 205             


Asp Asn Asp Asp Gly Arg Arg Ser Asn Ser Lys Ala Cys Gly Lys Leu 
    210                 215                 220                 


Asn Phe Ile Leu Lys Tyr Asp Cys Asp Leu Glu Gln Leu Ile Val Lys 
225                 230                 235                 240 


Ile His Lys Ala Val Asn Leu Pro Ala Lys Asp Phe Ser Gly Thr Ser 
                245                 250                 255     


Asp Pro Tyr Val Lys Ile Tyr Leu Leu Pro Asp Arg Lys Thr Lys His 
            260                 265                 270         


Gln Thr Lys Val His Arg Lys Thr Leu Asn Pro Val Phe Asp Glu Val 
        275                 280                 285             


Phe Leu Phe Pro Val Pro Tyr Asn Asp Leu Glu Ala Arg Lys Leu His 
    290                 295                 300                 


Phe Ser Val Tyr Asp Phe Asp Arg Phe Ser Arg His Asp Leu Ile Gly 
305                 310                 315                 320 


Gln Val Val Val Asp His Phe Leu Asp Leu Ala Asp Phe Pro Arg Glu 
                325                 330                 335     


Cys Ile Leu Trp Lys Asp Ile Glu Tyr Val Thr Asn Asp Asn Val Asp 
            340                 345                 350         


Leu Gly Glu Leu Met Phe Ser Leu Cys Tyr Leu Pro Thr Ala Gly Arg 
        355                 360                 365             


Leu Thr Ile Thr Ile Ile Lys Ala Arg Asn Leu Lys Ala Met Asp Ile 
    370                 375                 380                 


Thr Gly Ala Ser Asp Pro Tyr Val Lys Val Ser Leu Met Cys Asp Gly 
385                 390                 395                 400 


Arg Arg Leu Lys Lys Arg Lys Thr Ser Thr Lys Arg Asn Thr Leu Asn 
                405                 410                 415     


Pro Val Tyr Asn Glu Ala Ile Val Phe Asp Val Pro Pro Glu Asn Ile 
            420                 425                 430         


Asp Gln Ile His Leu Ser Ile Ala Val Met Asp Tyr Asp Arg Val Gly 
        435                 440                 445             


His Asn Glu Ile Ile Gly Val Cys Gln Val Gly Asn Glu Ala Glu Arg 
    450                 455                 460                 


Leu Gly Arg Asp His Trp Ser Glu Met Leu Ser Tyr Pro Arg Lys Pro 
465                 470                 475                 480 


Ile Ala His Trp His Ser Leu Val Glu Lys Arg 
                485                 490     


<210>  6456
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  6456

Met Glu Asn Gln Leu Trp His Asn Thr Val Arg Cys Cys Asn Gln Tyr 
1               5                   10                  15      


Gln Glu Ser Pro His Asp Ala Glu Asp Ile Leu Leu Leu Leu Leu Gly 
            20                  25                  30          


Leu Ile Val Leu Val Asn Ile Gly Ile Asn Val Ala Thr Met Met Trp 
        35                  40                  45              


His Gly Leu Gln Asn Ala Leu Asp Lys Met Ile Asp Trp Ala Thr Gln 
    50                  55                  60                  


Lys Asn Glu Ile Gln Ala Ser Glu Ser Pro Pro Ser Gly Pro Pro Asp 
65                  70                  75                  80  


Lys Ala Gln Asp Val His Ile His Cys Ile Leu Asp Pro Val Gln Val 
                85                  90                  95      


Lys Met Ser Arg Pro Thr Gln Tyr Ser Ser Phe Ser Cys His His Phe 
            100                 105                 110         


Ser Asn His His Ser Ser Ser Leu Leu Arg Cys Val Arg Arg Arg Arg 
        115                 120                 125             


Arg Arg His Arg Arg Cys Arg Arg Arg Cys Cys Asn His Gln Gln Arg 
    130                 135                 140                 


Pro Gln Asn Tyr Arg Gln Ile Pro His Ser His Ser Val Phe Arg Asn 
145                 150                 155                 160 


Pro His Arg Ser Gln Lys Met Ser Gln Leu His Arg Val Pro Phe Phe 
                165                 170                 175     


Asp Gln Glu Asp Pro Asp Ser Tyr Leu Glu Glu Glu Asp Asn Leu Pro 
            180                 185                 190         


Phe Pro Tyr Pro Lys Tyr Pro Arg Arg Gly Trp Gly Gly Phe Tyr Gln 
        195                 200                 205             


Arg Ala Gly Leu Pro Ser Asn Val Gly Leu Trp Gly His Gln Gly Gly 
    210                 215                 220                 


Ile Leu Ala Ser Leu Pro Pro Pro Ser Leu Tyr Leu Ser Pro Glu Leu 
225                 230                 235                 240 


Arg Cys Met Pro Lys Arg Val Glu Ala Arg Ser Glu Leu Arg Leu Gln 
                245                 250                 255     


Ser Tyr Gly Arg His Gly Ser Gln Ser Arg Leu Trp Gly Asn Val Glu 
            260                 265                 270         


Ala Glu Gln Trp Ala Ser Ser Pro Pro Pro Pro His Arg Leu Pro Pro 
        275                 280                 285             


Asn Pro Ser Trp Val Pro Val Gly His Ser Pro Tyr Pro Ser Val Gly 
    290                 295                 300                 


Trp Met Leu Tyr Asp Ser Trp Asp Gln Arg Arg Arg Gly Thr Glu Gly 
305                 310                 315                 320 


Phe Glu Arg Pro Pro Ala Ser Val Ser Arg Asn Ala Arg Pro Glu Ala 
                325                 330                 335     


Gln Gly Cys Arg Glu His His Ser Pro Gln Ser His Gln Gln Ser Leu 
            340                 345                 350         


Leu Gly His Ala Tyr Gly Gln Ser His Arg Ser Pro His Pro Ser Thr 
        355                 360                 365             


Glu Pro Leu Gly Tyr Ser Ser Gln Asp Pro Arg Glu Val Arg Arg Arg 
    370                 375                 380                 


Ala Ala Asp Trp Ala Glu Ala Leu Pro Ala Trp Arg Pro Leu Thr Thr 
385                 390                 395                 400 


Ser Ala Ser Leu Thr Val Leu Asp Glu Ala Ser His Gln Arg Thr Pro 
                405                 410                 415     


Ala Pro Ser Ser Val Leu Val Pro His Ser Ser Gln Pro Trp Pro Lys 
            420                 425                 430         


Val Gln Ala Ala Asp Pro Ala Pro Pro Pro Thr Met Phe Val Pro Leu 
        435                 440                 445             


Ser Arg Asn Pro Gly Gly Asn Ala Asn Tyr Gln Val Tyr Asp Ser Leu 
    450                 455                 460                 


Glu Leu Lys Arg Gln Val Gln Lys Ser Arg Ala Arg Ser Ser Ser Leu 
465                 470                 475                 480 


Pro Pro Ala Ser Thr Ser Thr Leu Arg Pro Ser Leu His Arg Ser Gln 
                485                 490                 495     


Thr Glu Lys Leu Asn 
            500     


<210>  6457
<211>  1044
<212>  PRT
<213>  Homo sapiens

<400>  6457

Met Lys Pro Gly Cys Ala Ala Gly Ser Pro Gly Asn Glu Trp Ile Phe 
1               5                   10                  15      


Phe Ser Thr Asp Glu Ile Thr Thr Arg Tyr Arg Asn Thr Met Ser Asn 
            20                  25                  30          


Gly Gly Leu Gln Arg Ser Val Ile Leu Ser Ala Leu Ile Leu Leu Arg 
        35                  40                  45              


Ala Val Thr Gly Phe Ser Gly Asp Gly Arg Ala Ile Trp Ser Lys Asn 
    50                  55                  60                  


Pro Asn Phe Thr Pro Val Asn Glu Ser Gln Leu Phe Leu Tyr Asp Thr 
65                  70                  75                  80  


Phe Pro Lys Asn Phe Phe Trp Gly Ile Gly Thr Gly Ala Leu Gln Val 
                85                  90                  95      


Glu Gly Ser Trp Lys Lys Asp Gly Lys Gly Pro Ser Ile Trp Asp His 
            100                 105                 110         


Phe Ile His Thr His Leu Lys Asn Val Ser Ser Thr Asn Gly Ser Ser 
        115                 120                 125             


Asp Ser Tyr Ile Phe Leu Glu Lys Asp Leu Ser Ala Leu Asp Phe Ile 
    130                 135                 140                 


Gly Val Ser Phe Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro 
145                 150                 155                 160 


Asp Gly Ile Val Thr Val Ala Asn Ala Lys Gly Leu Gln Tyr Tyr Ser 
                165                 170                 175     


Thr Leu Leu Asp Ala Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr 
            180                 185                 190         


Leu Tyr His Trp Asp Leu Pro Leu Ala Leu Gln Glu Lys Tyr Gly Gly 
        195                 200                 205             


Trp Lys Asn Asp Thr Ile Ile Asp Ile Phe Asn Asp Tyr Ala Thr Tyr 
    210                 215                 220                 


Cys Phe Gln Met Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His 
225                 230                 235                 240 


Asn Pro Tyr Leu Val Ala Trp His Gly Tyr Gly Thr Gly Met His Ala 
                245                 250                 255     


Pro Gly Glu Lys Gly Asn Leu Ala Ala Val Tyr Thr Val Gly His Asn 
            260                 265                 270         


Leu Ile Lys Ala His Ser Lys Val Trp His Asn Tyr Asn Thr His Phe 
        275                 280                 285             


Arg Pro His Gln Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp 
    290                 295                 300                 


Ile Glu Pro Asn Arg Ser Glu Asn Thr Met Asp Ile Phe Lys Cys Gln 
305                 310                 315                 320 


Gln Ser Met Val Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly 
                325                 330                 335     


Asp Gly Asp Tyr Pro Glu Gly Met Arg Lys Lys Leu Phe Ser Val Leu 
            340                 345                 350         


Pro Ile Phe Ser Glu Ala Glu Lys His Glu Met Arg Gly Thr Ala Asp 
        355                 360                 365             


Phe Phe Ala Phe Ser Phe Gly Pro Asn Asn Phe Lys Pro Leu Asn Thr 
    370                 375                 380                 


Met Ala Lys Met Gly Gln Asn Val Ser Leu Asn Leu Arg Glu Ala Leu 
385                 390                 395                 400 


Asn Trp Ile Lys Leu Glu Tyr Asn Asn Pro Arg Ile Leu Ile Ala Glu 
                405                 410                 415     


Asn Gly Trp Phe Thr Asp Ser Arg Val Lys Thr Glu Asp Thr Thr Ala 
            420                 425                 430         


Ile Tyr Met Met Lys Asn Phe Leu Ser Gln Val Leu Gln Ala Ile Arg 
        435                 440                 445             


Leu Asp Glu Ile Arg Val Phe Gly Tyr Thr Ala Trp Ser Leu Leu Asp 
    450                 455                 460                 


Gly Phe Glu Trp Gln Asp Ala Tyr Thr Ile Arg Arg Gly Leu Phe Tyr 
465                 470                 475                 480 


Val Asp Phe Asn Ser Lys Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala 
                485                 490                 495     


His Tyr Tyr Lys Gln Ile Ile Arg Glu Asn Gly Phe Ser Leu Lys Glu 
            500                 505                 510         


Ser Thr Pro Asp Val Gln Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly 
        515                 520                 525             


Val Thr Glu Ser Val Leu Lys Pro Glu Ser Val Ala Ser Ser Pro Gln 
    530                 535                 540                 


Phe Ser Asp Pro His Leu Tyr Val Trp Asn Ala Thr Gly Asn Arg Leu 
545                 550                 555                 560 


Leu His Arg Val Glu Gly Val Arg Leu Lys Thr Arg Pro Ala Gln Cys 
                565                 570                 575     


Thr Asp Phe Val Asn Ile Lys Lys Gln Leu Glu Met Leu Ala Arg Met 
            580                 585                 590         


Lys Val Thr His Tyr Arg Phe Ala Leu Asp Trp Ala Ser Val Leu Pro 
        595                 600                 605             


Thr Gly Asn Leu Ser Ala Val Asn Arg Gln Ala Leu Arg Tyr Tyr Arg 
    610                 615                 620                 


Cys Val Val Ser Glu Gly Leu Lys Leu Gly Ile Ser Ala Met Val Thr 
625                 630                 635                 640 


Leu Tyr Tyr Pro Thr His Ala His Leu Gly Leu Pro Glu Pro Leu Leu 
                645                 650                 655     


His Ala Asp Gly Trp Leu Asn Pro Ser Thr Ala Glu Ala Phe Gln Ala 
            660                 665                 670         


Tyr Ala Gly Leu Cys Phe Gln Glu Leu Gly Asp Leu Val Lys Leu Trp 
        675                 680                 685             


Ile Thr Ile Asn Glu Pro Asn Arg Leu Ser Asp Ile Tyr Asn Arg Ser 
    690                 695                 700                 


Gly Asn Asp Thr Tyr Gly Ala Ala His Asn Leu Leu Val Ala His Ala 
705                 710                 715                 720 


Leu Ala Trp Arg Leu Tyr Asp Arg Gln Phe Arg Pro Ser Gln Arg Gly 
                725                 730                 735     


Ala Val Ser Leu Ser Leu His Ala Asp Trp Ala Glu Pro Ala Asn Pro 
            740                 745                 750         


Tyr Ala Asp Ser His Trp Arg Ala Ala Glu Arg Phe Leu Gln Phe Glu 
        755                 760                 765             


Ile Ala Trp Phe Ala Glu Pro Leu Phe Lys Thr Gly Asp Tyr Pro Ala 
    770                 775                 780                 


Ala Met Arg Glu Tyr Ile Ala Ser Lys His Arg Arg Gly Leu Ser Ser 
785                 790                 795                 800 


Ser Ala Leu Pro Arg Leu Thr Glu Ala Glu Arg Arg Leu Leu Lys Gly 
                805                 810                 815     


Thr Val Asp Phe Cys Ala Leu Asn His Phe Thr Thr Arg Phe Val Met 
            820                 825                 830         


His Glu Gln Leu Ala Gly Ser Arg Tyr Asp Ser Asp Arg Asp Ile Gln 
        835                 840                 845             


Phe Leu Gln Asp Ile Thr Arg Leu Ser Ser Pro Thr Arg Leu Ala Val 
    850                 855                 860                 


Ile Pro Trp Gly Val Arg Lys Leu Leu Arg Trp Val Arg Arg Asn Tyr 
865                 870                 875                 880 


Gly Asp Met Asp Ile Tyr Ile Thr Ala Ser Gly Ile Asp Asp Gln Ala 
                885                 890                 895     


Leu Glu Asp Asp Arg Leu Arg Lys Tyr Tyr Leu Gly Lys Tyr Leu Gln 
            900                 905                 910         


Glu Val Leu Lys Ala Tyr Leu Ile Asp Lys Val Arg Ile Lys Gly Tyr 
        915                 920                 925             


Tyr Ala Phe Lys Leu Ala Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe 
    930                 935                 940                 


Phe Thr Ser Asp Phe Lys Ala Lys Ser Ser Ile Gln Phe Tyr Asn Lys 
945                 950                 955                 960 


Val Ile Ser Ser Arg Gly Phe Pro Phe Glu Asn Ser Ser Ser Arg Cys 
                965                 970                 975     


Ser Gln Thr Gln Glu Asn Thr Glu Cys Thr Val Cys Leu Phe Leu Val 
            980                 985                 990         


Gln Lys Lys Pro Leu Ile Phe Leu  Gly Cys Cys Phe Phe  Ser Thr Leu 
        995                 1000                 1005             


Val Leu  Leu Leu Ser Ile Ala  Ile Phe Gln Arg Gln  Lys Arg Arg 
    1010                 1015                 1020             


Lys Phe  Trp Lys Ala Lys Asn  Leu Gln His Ile Pro  Leu Lys Lys 
    1025                 1030                 1035             


Gly Lys  Arg Val Val Ser 
    1040                 


<210>  6458
<211>  435
<212>  PRT
<213>  Homo sapiens

<400>  6458

Met Gln Gly Gln Gly Arg Arg Arg Gly Thr Cys Lys Asp Ile Phe Cys 
1               5                   10                  15      


Ser Lys Met Ala Ser Tyr Leu Tyr Gly Val Leu Phe Ala Val Gly Leu 
            20                  25                  30          


Cys Ala Pro Ile Tyr Cys Val Ser Pro Ala Asn Ala Pro Ser Ala Tyr 
        35                  40                  45              


Pro Arg Pro Ser Ser Thr Lys Ser Thr Pro Ala Ser Gln Val Tyr Ser 
    50                  55                  60                  


Leu Asn Thr Asp Phe Ala Phe Arg Leu Tyr Arg Arg Leu Val Leu Glu 
65                  70                  75                  80  


Thr Pro Ser Gln Asn Ile Phe Phe Ser Pro Val Ser Val Ser Thr Ser 
                85                  90                  95      


Leu Ala Met Leu Ser Leu Gly Ala His Ser Val Thr Lys Thr Gln Ile 
            100                 105                 110         


Leu Gln Gly Leu Gly Phe Asn Leu Thr His Thr Pro Glu Ser Ala Ile 
        115                 120                 125             


His Gln Gly Phe Gln His Leu Val His Ser Leu Thr Val Pro Ser Lys 
    130                 135                 140                 


Asp Leu Thr Leu Lys Met Gly Ser Ala Leu Phe Val Lys Lys Glu Leu 
145                 150                 155                 160 


Gln Leu Gln Ala Asn Phe Leu Gly Asn Val Lys Arg Leu Tyr Glu Ala 
                165                 170                 175     


Glu Val Phe Ser Thr Asp Phe Ser Asn Pro Ser Ile Ala Gln Ala Arg 
            180                 185                 190         


Ile Asn Ser His Val Lys Lys Lys Thr Gln Gly Lys Val Val Asp Ile 
        195                 200                 205             


Ile Gln Gly Leu Asp Leu Leu Thr Ala Met Val Leu Val Asn His Ile 
    210                 215                 220                 


Phe Phe Lys Ala Lys Trp Glu Lys Pro Phe His Pro Glu Tyr Thr Arg 
225                 230                 235                 240 


Lys Asn Phe Pro Phe Leu Val Gly Glu Gln Val Thr Val His Val Pro 
                245                 250                 255     


Met Met His Gln Lys Glu Gln Phe Ala Phe Gly Val Asp Thr Glu Leu 
            260                 265                 270         


Asn Cys Phe Val Leu Gln Met Asp Tyr Lys Gly Asp Ala Val Ala Phe 
        275                 280                 285             


Phe Val Leu Pro Ser Lys Gly Lys Met Arg Gln Leu Glu Gln Ala Leu 
    290                 295                 300                 


Ser Ala Arg Thr Leu Arg Lys Trp Ser His Ser Leu Gln Lys Arg Trp 
305                 310                 315                 320 


Ile Glu Val Phe Ile Pro Arg Phe Ser Ile Ser Ala Ser Tyr Asn Leu 
                325                 330                 335     


Glu Thr Ile Leu Pro Lys Met Gly Ile Gln Asn Val Phe Asp Lys Asn 
            340                 345                 350         


Ala Asp Phe Ser Gly Ile Ala Lys Arg Asp Ser Leu Gln Val Ser Lys 
        355                 360                 365             


Ala Thr His Lys Ala Val Leu Asp Val Ser Glu Glu Gly Thr Glu Ala 
    370                 375                 380                 


Thr Ala Ala Thr Thr Thr Lys Phe Ile Val Arg Ser Lys Asp Gly Pro 
385                 390                 395                 400 


Ser Tyr Phe Thr Val Ser Phe Asn Arg Thr Phe Leu Met Met Ile Thr 
                405                 410                 415     


Asn Lys Ala Thr Asp Gly Ile Leu Phe Leu Gly Lys Val Glu Asn Pro 
            420                 425                 430         


Thr Lys Ser 
        435 


<210>  6459
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  6459

Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Asn Ile Ala Ser Phe 
                325                 


<210>  6460
<211>  869
<212>  PRT
<213>  Homo sapiens

<400>  6460

Met Lys Ile Ile Phe Pro Ile Leu Ser Asn Pro Val Phe Arg Arg Thr 
1               5                   10                  15      


Val Lys Leu Leu Leu Cys Leu Leu Trp Ile Gly Tyr Ser Gln Gly Thr 
            20                  25                  30          


Thr His Val Leu Arg Phe Gly Gly Ile Phe Glu Tyr Val Glu Ser Gly 
        35                  40                  45              


Pro Met Gly Ala Glu Glu Leu Ala Phe Arg Phe Ala Val Asn Thr Ile 
    50                  55                  60                  


Asn Arg Asn Arg Thr Leu Leu Pro Asn Thr Thr Leu Thr Tyr Asp Thr 
65                  70                  75                  80  


Gln Lys Ile Asn Leu Tyr Asp Ser Phe Glu Ala Ser Lys Lys Ala Cys 
                85                  90                  95      


Asp Gln Leu Ser Leu Gly Val Ala Ala Ile Phe Gly Pro Ser His Ser 
            100                 105                 110         


Ser Ser Ala Asn Ala Val Gln Ser Ile Cys Asn Ala Leu Gly Val Pro 
        115                 120                 125             


His Ile Gln Thr Arg Trp Lys His Gln Val Ser Asp Asn Lys Asp Ser 
    130                 135                 140                 


Phe Tyr Val Ser Leu Tyr Pro Asp Phe Ser Ser Leu Ser Arg Ala Ile 
145                 150                 155                 160 


Leu Asp Leu Val Gln Phe Phe Lys Trp Lys Thr Val Thr Val Val Tyr 
                165                 170                 175     


Asp Asp Ser Thr Gly Leu Ile Arg Leu Gln Glu Leu Ile Lys Ala Pro 
            180                 185                 190         


Ser Arg Tyr Asn Leu Arg Leu Lys Ile Arg Gln Leu Pro Ala Asp Thr 
        195                 200                 205             


Lys Asp Ala Lys Pro Leu Leu Lys Glu Met Lys Arg Gly Lys Glu Phe 
    210                 215                 220                 


His Val Ile Phe Asp Cys Ser His Glu Met Ala Ala Gly Ile Leu Lys 
225                 230                 235                 240 


Gln Ala Leu Ala Met Gly Met Met Thr Glu Tyr Tyr His Tyr Ile Phe 
                245                 250                 255     


Thr Thr Leu Asp Leu Phe Ala Leu Asp Val Glu Pro Tyr Arg Tyr Ser 
            260                 265                 270         


Gly Val Asn Met Thr Gly Phe Arg Ile Leu Asn Thr Glu Asn Thr Gln 
        275                 280                 285             


Val Ser Ser Ile Ile Glu Lys Trp Ser Met Glu Arg Leu Gln Ala Pro 
    290                 295                 300                 


Pro Lys Pro Asp Ser Gly Leu Leu Asp Gly Phe Met Thr Thr Asp Ala 
305                 310                 315                 320 


Ala Leu Met Tyr Asp Ala Val His Val Val Ser Val Ala Val Gln Gln 
                325                 330                 335     


Phe Pro Gln Met Thr Val Ser Ser Leu Gln Cys Asn Arg His Lys Pro 
            340                 345                 350         


Trp Arg Phe Gly Thr Arg Phe Met Ser Leu Ile Lys Glu Ala His Trp 
        355                 360                 365             


Glu Gly Leu Thr Gly Arg Ile Thr Phe Asn Lys Thr Asn Gly Leu Arg 
    370                 375                 380                 


Thr Asp Phe Asp Leu Asp Val Ile Ser Leu Lys Glu Glu Gly Leu Glu 
385                 390                 395                 400 


Lys Ile Gly Thr Trp Asp Pro Ala Ser Gly Leu Asn Met Thr Glu Ser 
                405                 410                 415     


Gln Lys Gly Lys Pro Ala Asn Ile Thr Asp Ser Leu Ser Asn Arg Ser 
            420                 425                 430         


Leu Ile Val Thr Thr Ile Leu Glu Glu Pro Tyr Val Leu Phe Lys Lys 
        435                 440                 445             


Ser Asp Lys Pro Leu Tyr Gly Asn Asp Arg Phe Glu Gly Tyr Cys Ile 
    450                 455                 460                 


Asp Leu Leu Arg Glu Leu Ser Thr Ile Leu Gly Phe Thr Tyr Glu Ile 
465                 470                 475                 480 


Arg Leu Val Glu Asp Gly Lys Tyr Gly Ala Gln Asp Asp Ala Asn Gly 
                485                 490                 495     


Gln Trp Asn Gly Met Val Arg Glu Leu Ile Asp His Lys Ala Asp Leu 
            500                 505                 510         


Ala Val Ala Pro Leu Ala Ile Thr Tyr Val Arg Glu Lys Val Ile Asp 
        515                 520                 525             


Phe Ser Lys Pro Phe Met Thr Leu Gly Ile Ser Ile Leu Tyr Arg Lys 
    530                 535                 540                 


Pro Asn Gly Thr Asn Pro Gly Val Phe Ser Phe Leu Asn Pro Leu Ser 
545                 550                 555                 560 


Pro Asp Ile Trp Met Tyr Ile Leu Leu Ala Tyr Leu Gly Val Ser Cys 
                565                 570                 575     


Val Leu Phe Val Ile Ala Arg Phe Ser Pro Tyr Glu Trp Tyr Asn Pro 
            580                 585                 590         


His Pro Cys Asn Pro Asp Ser Asp Val Val Glu Asn Asn Phe Thr Leu 
        595                 600                 605             


Leu Asn Ser Phe Trp Phe Gly Val Gly Ala Leu Met Gln Gln Gly Ser 
    610                 615                 620                 


Glu Leu Met Pro Lys Ala Leu Ser Thr Arg Ile Val Gly Gly Ile Trp 
625                 630                 635                 640 


Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala 
                645                 650                 655     


Ala Phe Leu Thr Val Glu Arg Met Glu Ser Pro Ile Asp Ser Ala Asp 
            660                 665                 670         


Asp Leu Ala Lys Gln Thr Lys Ile Glu Tyr Gly Ala Val Glu Asp Gly 
        675                 680                 685             


Ala Thr Met Thr Phe Phe Lys Lys Ser Lys Ile Ser Thr Tyr Asp Lys 
    690                 695                 700                 


Met Trp Ala Phe Met Ser Ser Arg Arg Gln Ser Val Leu Val Lys Ser 
705                 710                 715                 720 


Asn Glu Glu Gly Ile Gln Arg Val Leu Thr Ser Asp Tyr Ala Phe Leu 
                725                 730                 735     


Met Glu Ser Thr Thr Ile Glu Phe Val Thr Gln Arg Asn Cys Asn Leu 
            740                 745                 750         


Thr Gln Ile Gly Gly Leu Ile Asp Ser Lys Gly Tyr Gly Val Gly Thr 
        755                 760                 765             


Pro Met Gly Ser Pro Tyr Arg Asp Lys Ile Thr Ile Ala Ile Leu Gln 
    770                 775                 780                 


Leu Gln Glu Glu Gly Lys Leu His Met Met Lys Glu Lys Trp Trp Arg 
785                 790                 795                 800 


Gly Asn Gly Cys Pro Glu Glu Glu Ser Lys Glu Ala Ser Ala Leu Gly 
                805                 810                 815     


Val Gln Asn Ile Gly Gly Ile Phe Ile Val Leu Ala Ala Gly Leu Val 
            820                 825                 830         


Leu Ser Val Phe Val Ala Val Gly Glu Phe Leu Tyr Lys Ser Lys Lys 
        835                 840                 845             


Asn Ala Gln Leu Glu Lys Glu Ser Ser Ile Trp Leu Val Pro Pro Tyr 
    850                 855                 860                 


His Pro Asp Thr Val 
865                 


<210>  6461
<211>  882
<212>  PRT
<213>  Homo sapiens

<400>  6461

Met Ala Val Arg Ser Arg Arg Pro Trp Met Ser Val Ala Leu Gly Leu 
1               5                   10                  15      


Val Leu Gly Phe Thr Ala Ala Ser Trp Leu Ile Ala Pro Arg Val Ala 
            20                  25                  30          


Glu Leu Ser Glu Arg Lys Arg Arg Gly Ser Ser Leu Cys Ser Tyr Tyr 
        35                  40                  45              


Gly Arg Ser Ala Ala Gly Pro Arg Ala Gly Ala Gln Gln Pro Leu Pro 
    50                  55                  60                  


Gln Pro Gln Ser Arg Pro Arg Gln Glu Gln Ser Pro Pro Pro Ala Arg 
65                  70                  75                  80  


Gln Asp Leu Gln Gly Pro Pro Leu Pro Glu Ala Ala Pro Gly Ile Thr 
                85                  90                  95      


Ser Phe Arg Ser Ser Pro Trp Gln Gln Pro Pro Pro Leu Gln Gln Arg 
            100                 105                 110         


Arg Arg Gly Arg Glu Pro Glu Gly Ala Thr Gly Leu Pro Gly Ala Pro 
        115                 120                 125             


Ala Ala Glu Gly Glu Pro Glu Glu Glu Asp Gly Gly Ala Ala Gly Gln 
    130                 135                 140                 


Arg Arg Asp Gly Arg Pro Gly Ser Ser His Asn Gly Ser Gly Asp Gly 
145                 150                 155                 160 


Gly Ala Ala Ala Pro Ser Ala Arg Pro Arg Asp Phe Leu Tyr Val Gly 
                165                 170                 175     


Val Met Thr Ala Gln Lys Tyr Leu Gly Ser Arg Ala Leu Ala Ala Gln 
            180                 185                 190         


Arg Thr Trp Ala Arg Phe Ile Pro Gly Arg Val Glu Phe Phe Ser Ser 
        195                 200                 205             


Gln Gln Pro Pro Asn Ala Gly Gln Pro Pro Pro Pro Leu Pro Val Ile 
    210                 215                 220                 


Ala Leu Pro Gly Val Asp Asp Ser Tyr Pro Pro Gln Lys Lys Ser Phe 
225                 230                 235                 240 


Met Met Ile Lys Tyr Met His Asp His Tyr Leu Asp Lys Tyr Glu Trp 
                245                 250                 255     


Phe Met Arg Ala Asp Asp Asp Val Tyr Ile Lys Gly Asp Lys Leu Glu 
            260                 265                 270         


Glu Phe Leu Arg Ser Leu Asn Ser Ser Lys Pro Leu Tyr Leu Gly Gln 
        275                 280                 285             


Thr Gly Leu Gly Asn Ile Glu Glu Leu Gly Lys Leu Gly Leu Glu Pro 
    290                 295                 300                 


Gly Glu Asn Phe Cys Met Gly Gly Pro Gly Met Ile Phe Ser Arg Glu 
305                 310                 315                 320 


Val Leu Arg Arg Met Val Pro His Ile Gly Glu Cys Leu Arg Glu Met 
                325                 330                 335     


Tyr Thr Thr His Glu Asp Val Glu Val Gly Arg Cys Val Arg Arg Phe 
            340                 345                 350         


Gly Gly Thr Gln Cys Val Trp Ser Tyr Glu Met Gln Gln Leu Phe His 
        355                 360                 365             


Glu Asn Tyr Glu His Asn Arg Lys Gly Tyr Ile Gln Asp Leu His Asn 
    370                 375                 380                 


Ser Lys Ile His Ala Ala Ile Thr Leu His Pro Asn Lys Arg Pro Ala 
385                 390                 395                 400 


Tyr Gln Tyr Arg Leu His Asn Tyr Met Leu Ser Arg Lys Ile Ser Glu 
                405                 410                 415     


Leu Arg Tyr Arg Thr Ile Gln Leu His Arg Glu Ser Ala Leu Met Ser 
            420                 425                 430         


Lys Leu Ser Asn Thr Glu Val Ser Lys Glu Asp Gln Gln Leu Gly Val 
        435                 440                 445             


Ile Pro Ser Phe Asn His Phe Gln Pro Arg Glu Arg Asn Glu Val Ile 
    450                 455                 460                 


Glu Trp Glu Phe Leu Thr Gly Lys Leu Leu Tyr Ser Ala Ala Glu Asn 
465                 470                 475                 480 


Gln Pro Pro Arg Gln Ser Leu Ser Ser Ile Leu Arg Thr Ala Leu Asp 
                485                 490                 495     


Asp Thr Val Leu Gln Val Met Glu Met Ile Asn Glu Asn Ala Lys Ser 
            500                 505                 510         


Arg Gly Arg Leu Ile Asp Phe Lys Glu Ile Gln Tyr Gly Tyr Arg Arg 
        515                 520                 525             


Val Asn Pro Met His Gly Val Glu Tyr Ile Leu Asp Leu Leu Leu Leu 
    530                 535                 540                 


Tyr Lys Arg His Lys Gly Arg Lys Leu Thr Val Pro Val Arg Arg His 
545                 550                 555                 560 


Ala Tyr Leu Gln Gln Leu Phe Ser Lys Pro Phe Phe Arg Glu Thr Glu 
                565                 570                 575     


Glu Leu Asp Val Asn Ser Leu Val Glu Ser Ile Asn Ser Glu Thr Gln 
            580                 585                 590         


Ser Phe Ser Phe Ile Ser Asn Ser Leu Lys Ile Leu Ser Ser Phe Gln 
        595                 600                 605             


Gly Ala Lys Glu Met Gly Gly His Asn Glu Lys Lys Val His Ile Leu 
    610                 615                 620                 


Val Pro Leu Ile Gly Arg Tyr Asp Ile Phe Leu Arg Phe Met Glu Asn 
625                 630                 635                 640 


Phe Glu Asn Met Cys Leu Ile Pro Lys Gln Asn Val Lys Leu Val Ile 
                645                 650                 655     


Ile Leu Phe Ser Arg Asp Ser Gly Gln Asp Ser Ser Lys His Ile Glu 
            660                 665                 670         


Leu Ile Lys Gly Tyr Gln Asn Lys Tyr Pro Lys Ala Glu Met Thr Leu 
        675                 680                 685             


Ile Pro Met Lys Gly Glu Phe Ser Arg Gly Leu Gly Leu Glu Met Ala 
    690                 695                 700                 


Ser Ala Gln Phe Asp Asn Asp Thr Leu Leu Leu Phe Cys Asp Val Asp 
705                 710                 715                 720 


Leu Ile Phe Arg Glu Asp Phe Leu Gln Arg Cys Arg Asp Asn Thr Ile 
                725                 730                 735     


Gln Gly Gln Gln Val Tyr Tyr Pro Ile Ile Phe Ser Gln Tyr Asp Pro 
            740                 745                 750         


Lys Val Thr Asn Gly Gly Asn Pro Pro Thr Asp Asp Tyr Phe Ile Phe 
        755                 760                 765             


Ser Lys Lys Thr Gly Phe Trp Arg Asp Tyr Gly Tyr Gly Ile Thr Cys 
    770                 775                 780                 


Ile Tyr Lys Ser Asp Leu Leu Gly Ala Gly Gly Phe Asp Thr Ser Ile 
785                 790                 795                 800 


Gln Gly Trp Gly Leu Glu Asp Val Asp Leu Tyr Asn Lys Val Ile Leu 
                805                 810                 815     


Ser Gly Leu Arg Pro Phe Arg Ser Gln Glu Val Gly Val Val His Ile 
            820                 825                 830         


Phe His Pro Val His Cys Asp Pro Asn Leu Asp Pro Lys Gln Tyr Lys 
        835                 840                 845             


Met Cys Leu Gly Ser Lys Ala Ser Thr Phe Ala Ser Thr Met Gln Leu 
    850                 855                 860                 


Ala Glu Leu Trp Leu Glu Lys His Leu Gly Val Arg Tyr Asn Arg Thr 
865                 870                 875                 880 


Leu Ser 
        


<210>  6462
<211>  774
<212>  PRT
<213>  Homo sapiens

<400>  6462

Met Asn Pro Phe Tyr Phe His Ala Val Asn Ile Ile Leu His Cys Leu 
1               5                   10                  15      


Val Thr Leu Val Leu Met Tyr Thr Cys Asp Lys Thr Val Phe Lys Asn 
            20                  25                  30          


Arg Gly Leu Ala Phe Val Thr Ala Leu Leu Phe Ala Val His Pro Ile 
        35                  40                  45              


His Thr Glu Ala Val Ala Gly Ile Val Gly Arg Ala Asp Val Leu Ala 
    50                  55                  60                  


Cys Leu Leu Phe Leu Leu Ala Phe Leu Ser Tyr Asn Arg Ser Leu Asp 
65                  70                  75                  80  


Gln Gly Cys Val Gly Gly Ser Phe Pro Ser Thr Val Ser Pro Phe Phe 
                85                  90                  95      


Leu Leu Leu Ser Leu Phe Leu Gly Thr Cys Ala Met Leu Val Lys Glu 
            100                 105                 110         


Thr Gly Ile Thr Val Phe Gly Val Cys Leu Val Tyr Asp Leu Phe Ser 
        115                 120                 125             


Leu Ser Asn Lys Gln Asp Lys Ser Ser Asn Gly Ala Leu Cys Pro Arg 
    130                 135                 140                 


Ser Pro Gln Gln Pro Gly Ser Pro Gln Pro Ser Ser Leu Pro Gly His 
145                 150                 155                 160 


Pro His Arg Glu Asn Gly Lys Gln Gln Arg Phe Pro His Lys Gly Ala 
                165                 170                 175     


Trp Gly Gly Cys His Ser Pro Leu Pro Pro Glu Pro Lys Ser Ser Gly 
            180                 185                 190         


Phe Pro Val Ser Pro Arg Ala Val Trp Ser Met Met Arg Phe Leu Thr 
        195                 200                 205             


Tyr Ser Tyr Leu Leu Ala Phe Asn Val Trp Leu Leu Leu Ala Pro Val 
    210                 215                 220                 


Thr Leu Cys Tyr Asp Trp Gln Val Gly Ser Ile Pro Leu Val Glu Thr 
225                 230                 235                 240 


Ile Trp Asp Met Arg Asn Leu Ala Thr Ile Phe Leu Ala Val Val Met 
                245                 250                 255     


Ala Leu Leu Ser Leu His Cys Leu Ala Ala Phe Lys Arg Leu Glu His 
            260                 265                 270         


Lys Glu Val Leu Val Gly Leu Leu Phe Leu Val Phe Pro Phe Ile Pro 
        275                 280                 285             


Ala Ser Asn Leu Phe Phe Arg Val Gly Phe Val Val Ala Glu Arg Val 
    290                 295                 300                 


Leu Tyr Met Pro Ser Met Gly Tyr Cys Ile Leu Phe Val His Gly Leu 
305                 310                 315                 320 


Ser Lys Leu Cys Thr Trp Leu Asn Arg Cys Gly Ala Thr Thr Leu Ile 
                325                 330                 335     


Val Ser Thr Val Leu Leu Leu Leu Leu Phe Ser Trp Lys Thr Val Lys 
            340                 345                 350         


Gln Asn Glu Ile Trp Leu Ser Arg Glu Ser Leu Phe Arg Ser Gly Val 
        355                 360                 365             


Gln Thr Leu Pro His Asn Ala Lys Val His Tyr Asn Tyr Ala Asn Phe 
    370                 375                 380                 


Leu Lys Asp Gln Gly Arg Asn Lys Glu Ala Ile Tyr His Tyr Arg Thr 
385                 390                 395                 400 


Ala Leu Lys Leu Tyr Pro Arg His Ala Ser Ala Leu Asn Asn Leu Gly 
                405                 410                 415     


Thr Leu Thr Arg Asp Thr Ala Glu Ala Lys Met Tyr Tyr Gln Arg Ala 
            420                 425                 430         


Leu Gln Leu His Pro Gln His Asn Arg Ala Leu Phe Asn Leu Gly Asn 
        435                 440                 445             


Leu Leu Lys Ser Gln Glu Lys Lys Glu Glu Ala Ile Thr Leu Leu Lys 
    450                 455                 460                 


Asp Ser Ile Lys Tyr Gly Pro Glu Phe Ala Asp Ala Tyr Ser Ser Leu 
465                 470                 475                 480 


Ala Ser Leu Leu Ala Glu Gln Glu Arg Phe Lys Glu Ala Glu Glu Ile 
                485                 490                 495     


Tyr Gln Thr Gly Ile Lys Asn Cys Pro Asp Ser Ser Asp Leu His Asn 
            500                 505                 510         


Asn Tyr Gly Val Phe Leu Val Asp Thr Gly Leu Pro Glu Lys Ala Val 
        515                 520                 525             


Ala His Tyr Gln Gln Ala Ile Lys Leu Ser Pro Ser His His Val Ala 
    530                 535                 540                 


Met Val Asn Leu Gly Arg Leu Tyr Arg Ser Leu Gly Glu Asn Ser Met 
545                 550                 555                 560 


Ala Glu Glu Trp Tyr Lys Arg Ala Leu Gln Val Ala His Lys Ala Glu 
                565                 570                 575     


Ile Leu Ser Pro Leu Gly Ala Leu Tyr Tyr Asn Thr Gly Arg Tyr Glu 
            580                 585                 590         


Glu Ala Leu Gln Ile Tyr Gln Glu Ala Ala Ala Leu Gln Pro Ser Gln 
        595                 600                 605             


Arg Glu Leu Arg Leu Ala Leu Ala Gln Val Leu Ala Val Met Gly Gln 
    610                 615                 620                 


Thr Lys Glu Ala Glu Lys Met Thr Asn His Ile Val Ser Glu Glu Thr 
625                 630                 635                 640 


Gly Cys Leu Glu Cys Tyr Arg Leu Leu Ser Ala Ile Tyr Ser Lys Gln 
                645                 650                 655     


Glu Asn His Asp Lys Ala Leu Asp Ala Ile Asp Lys Ala Leu Gln Leu 
            660                 665                 670         


Lys Pro Lys Asp Pro Lys Val Ile Ser Glu Leu Phe Phe Thr Lys Gly 
        675                 680                 685             


Asn Gln Leu Arg Glu Gln Asn Leu Leu Asp Lys Ala Phe Glu Ser Tyr 
    690                 695                 700                 


Arg Val Ala Val Gln Leu Asn Pro Asp Gln Ala Gln Ala Trp Met Asn 
705                 710                 715                 720 


Met Gly Gly Ile Gln His Ile Lys Gly Lys Tyr Val Ser Ala Arg Ala 
                725                 730                 735     


Tyr Tyr Glu Arg Ala Leu Gln Leu Val Pro Asp Ser Lys Leu Leu Lys 
            740                 745                 750         


Glu Asn Leu Ala Lys Leu Asp Arg Leu Glu Lys Arg Leu Gln Glu Val 
        755                 760                 765             


Arg Glu Lys Asp Gln Thr 
    770                 


<210>  6463
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  6463

Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val Met 
1               5                   10                  15      


Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe 
            20                  25                  30          


Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln 
        35                  40                  45              


Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val 
    50                  55                  60                  


Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe Asp Ser Val His Ser 
65                  70                  75                  80  


Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg 
                85                  90                  95      


Leu His Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile 
            100                 105                 110         


His His Lys Lys Pro Thr Gly Met Ile Arg Ile His Gln Met Asn Ser 
        115                 120                 125             


Glu Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile 
    130                 135                 140                 


Ser Asn Ile Thr Glu Asn Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile 
145                 150                 155                 160 


His Gly Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys 
                165                 170                 175     


Asn Ser Thr Ile Glu Tyr Asp Gly Ile Met Gln Lys Ser Gln Asp Asn 
            180                 185                 190         


Val Thr Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro 
        195                 200                 205             


Asp Val Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys 
    210                 215                 220                 


Thr Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
225                 230                 235                 240 


Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr Val 
                245                 250                 255     


Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys 
            260                 265                 270         


Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn Thr Met Glu 
        275                 280                 285             


Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys Ile His Ile Pro 
    290                 295                 300                 


Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys Ser Ser Lys Thr Ser 
305                 310                 315                 320 


Ser Cys Asp Lys Ser Asp Thr Cys Phe 
                325                 


<210>  6464
<211>  684
<212>  PRT
<213>  Homo sapiens

<400>  6464

Met Ala Cys Leu Gly Phe Leu Leu Pro Val Gly Phe Leu Leu Leu Ile 
1               5                   10                  15      


Ser Thr Val Ala Gly Gly Lys Tyr Gly Val Ala His Val Val Ser Glu 
            20                  25                  30          


Asn Trp Ser Lys Asp Tyr Cys Ile Leu Phe Ser Ser Asp Tyr Ile Thr 
        35                  40                  45              


Leu Pro Arg Asp Leu His His Ala Pro Leu Leu Pro Leu Tyr Asp Gly 
    50                  55                  60                  


Thr Lys Ala Pro Trp Cys Pro Gly Glu Asp Ser Pro His Gln Ala Gln 
65                  70                  75                  80  


Leu Arg Ser Pro Ser Gln Arg Pro Leu Arg Gln Thr Thr Ala Met Val 
                85                  90                  95      


Met Arg Gly Asn Cys Ser Phe His Thr Lys Gly Trp Leu Ala Gln Gly 
            100                 105                 110         


Gln Gly Ala His Gly Leu Leu Ile Val Ser Arg Val Ser Asp Gln Gln 
        115                 120                 125             


Cys Ser Asp Thr Thr Leu Ala Pro Gln Asp Pro Arg Gln Pro Leu Ala 
    130                 135                 140                 


Asp Leu Thr Ile Pro Val Ala Met Leu His Tyr Ala Asp Met Leu Asp 
145                 150                 155                 160 


Ile Leu Ser His Thr Arg Gly Glu Ala Val Val Arg Val Ala Met Tyr 
                165                 170                 175     


Ala Pro Pro Glu Pro Ile Ile Asp Tyr Asn Met Leu Val Ile Phe Ile 
            180                 185                 190         


Leu Ala Val Gly Thr Val Ala Ala Gly Gly Tyr Trp Ala Gly Leu Thr 
        195                 200                 205             


Glu Ala Asn Arg Leu Gln Arg Arg Arg Ala Arg Arg Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly His His Gln Leu Gln Glu Ala Ala Ala Ala Glu Gly Ala Gln 
225                 230                 235                 240 


Lys Glu Asp Asn Glu Asp Ile Pro Val Asp Phe Thr Pro Ala Met Thr 
                245                 250                 255     


Gly Val Val Val Thr Leu Ser Cys Ser Leu Met Leu Leu Leu Tyr Phe 
            260                 265                 270         


Phe Tyr Asp His Phe Val Tyr Val Thr Ile Gly Ile Phe Gly Leu Gly 
        275                 280                 285             


Ala Gly Ile Gly Leu Tyr Ser Cys Leu Ser Pro Leu Val Cys Arg Leu 
    290                 295                 300                 


Ser Leu Arg Gln Tyr Gln Arg Pro Pro His Ser Leu Trp Ala Ser Leu 
305                 310                 315                 320 


Pro Leu Pro Leu Leu Leu Leu Ala Ser Leu Cys Ala Thr Val Ile Ile 
                325                 330                 335     


Phe Trp Val Ala Tyr Arg Asn Glu Asp Arg Trp Ala Trp Leu Leu Gln 
            340                 345                 350         


Asp Thr Leu Gly Ile Ser Tyr Cys Leu Phe Val Leu His Arg Val Arg 
        355                 360                 365             


Leu Pro Thr Leu Lys Asn Cys Ser Ser Phe Leu Leu Ala Leu Leu Ala 
    370                 375                 380                 


Phe Asp Val Phe Phe Val Phe Val Thr Pro Phe Phe Thr Lys Thr Gly 
385                 390                 395                 400 


Glu Ser Ile Met Ala Gln Val Ala Leu Gly Pro Ala Glu Ser Ser Ser 
                405                 410                 415     


His Glu Arg Leu Pro Met Val Leu Lys Val Pro Arg Leu Arg Val Ser 
            420                 425                 430         


Ala Leu Thr Leu Cys Ser Gln Pro Phe Ser Ile Leu Gly Phe Gly Asp 
        435                 440                 445             


Ile Val Val Pro Gly Phe Leu Val Ala Tyr Cys Cys Arg Phe Asp Val 
    450                 455                 460                 


Gln Val Cys Ser Arg Gln Ile Tyr Phe Val Ala Cys Thr Val Ala Tyr 
465                 470                 475                 480 


Ala Val Gly Leu Leu Val Thr Phe Met Ala Met Val Leu Met Gln Met 
                485                 490                 495     


Gly Gln Pro Ala Leu Leu Tyr Leu Val Ser Ser Thr Leu Leu Thr Ser 
            500                 505                 510         


Leu Ala Val Ala Ala Cys Arg Gln Glu Leu Ser Leu Phe Trp Thr Gly 
        515                 520                 525             


Gln Gly Arg Ala Lys Met Cys Gly Leu Gly Cys Ala Pro Ser Ala Gly 
    530                 535                 540                 


Ser Arg Gln Lys Gln Glu Gly Ala Ala Asp Ala His Thr Ala Ser Thr 
545                 550                 555                 560 


Leu Glu Arg Gly Thr Ser Arg Gly Ala Gly Asp Leu Asp Ser Asn Pro 
                565                 570                 575     


Gly Glu Asp Thr Thr Glu Ile Val Thr Ile Ser Glu Asn Glu Ala Thr 
            580                 585                 590         


Asn Pro Glu Asp Arg Ser Asp Ser Ser Glu Gly Trp Ser Asp Ala His 
        595                 600                 605             


Leu Asp Pro Asn Glu Leu Pro Phe Ile Pro Pro Gly Ala Ser Glu Glu 
    610                 615                 620                 


Leu Met Pro Leu Met Pro Met Ala Met Leu Ile Pro Leu Met Pro Leu 
625                 630                 635                 640 


Met Pro Pro Pro Ser Glu Leu Gly His Val His Ala Gln Ala Gln Ala 
                645                 650                 655     


His Glu Thr Gly Leu Pro Trp Ala Gly Leu His Lys Arg Lys Gly Leu 
            660                 665                 670         


Lys Val Arg Lys Ser Met Ser Thr Gln Ala Pro Leu 
        675                 680                 


<210>  6465
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  6465

Met Glu Ala Gly Asn Gln Thr Gly Phe Leu Glu Phe Ile Leu Leu Gly 
1               5                   10                  15      


Leu Ser Glu Asp Pro Glu Leu Gln Pro Phe Ile Phe Gly Leu Phe Leu 
            20                  25                  30          


Ser Met Tyr Leu Val Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Ala 
        35                  40                  45              


Ile Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 
    50                  55                  60                  


Asn Leu Ser Trp Val Asp Ile Cys Phe Ser Thr Cys Ile Val Pro Lys 
65                  70                  75                  80  


Met Leu Val Asn Ile Gln Thr Glu Asn Lys Ala Ile Ser Tyr Met Asp 
                85                  90                  95      


Cys Leu Thr Gln Val Tyr Phe Ser Met Phe Phe Pro Ile Leu Asp Thr 
            100                 105                 110         


Leu Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Val Cys His 
        115                 120                 125             


Pro Leu His Tyr Met Ile Ile Met Asn Pro His Leu Cys Gly Leu Leu 
    130                 135                 140                 


Val Phe Val Thr Trp Leu Ile Gly Val Met Thr Ser Leu Leu His Ile 
145                 150                 155                 160 


Ser Leu Met Met His Leu Ile Phe Cys Lys Asp Phe Glu Ile Pro His 
                165                 170                 175     


Phe Phe Cys Glu Leu Thr Tyr Ile Leu Gln Leu Ala Cys Ser Asp Thr 
            180                 185                 190         


Phe Leu Asn Ser Thr Leu Ile Tyr Phe Met Thr Gly Val Leu Gly Val 
        195                 200                 205             


Phe Pro Leu Leu Gly Ile Ile Phe Ser Tyr Ser Arg Ile Ala Ser Ser 
    210                 215                 220                 


Ile Arg Lys Met Ser Ser Ser Gly Gly Lys Gln Lys Ala Leu Ser Thr 
225                 230                 235                 240 


Cys Gly Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Gly Ile 
                245                 250                 255     


Gly Val His Phe Thr Ser Ala Val Thr His Ser Ser Gln Lys Ile Ser 
            260                 265                 270         


Val Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Gly Ser Leu 
    290                 295                 300                 


Leu Ser Arg Ala Ala Ser Cys Leu 
305                 310         


<210>  6466
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  6466

Met Pro Leu Thr Pro Glu Pro Pro Ser Gly Arg Val Glu Gly Pro Pro 
1               5                   10                  15      


Ala Trp Glu Ala Ala Pro Trp Pro Ser Leu Pro Cys Gly Pro Cys Ile 
            20                  25                  30          


Pro Ile Met Leu Val Leu Ala Thr Leu Ala Ala Leu Phe Ile Leu Thr 
        35                  40                  45              


Thr Ala Val Leu Ala Glu Arg Leu Phe Arg Arg Ala Leu Arg Pro Asp 
    50                  55                  60                  


Pro Ser His Arg Ala Pro Thr Leu Val Trp Arg Pro Gly Gly Glu Leu 
65                  70                  75                  80  


Trp Ile Glu Pro Met Gly Thr Ala Arg Glu Arg Ser Glu Asp Trp Tyr 
                85                  90                  95      


Gly Ser Ala Val Pro Leu Leu Thr Asp Arg Ala Pro Glu Pro Pro Thr 
            100                 105                 110         


Gln Val Gly Thr Leu Glu Ala Arg Ala Thr Ala Pro Pro Ala Pro Ser 
        115                 120                 125             


Ala Pro Asn Ser Ala Pro Ser Asn Leu Gly Pro Gln Thr Val Leu Glu 
    130                 135                 140                 


Val Pro Ala Arg Ser Thr Phe Trp Gly Pro Gln Pro Trp Glu Gly Arg 
145                 150                 155                 160 


Pro Pro Ala Thr Gly Leu Val Ser Trp Ala Glu Pro Glu Gln Arg Pro 
                165                 170                 175     


Glu Ala Ser Val Gln Phe Gly Ser Pro Gln Ala Arg Arg Gln Arg Pro 
            180                 185                 190         


Gly Ser Pro Asp Pro Glu Trp Gly Leu Gln Pro Arg Val Thr Leu Glu 
        195                 200                 205             


Gln Ile Ser Ala Phe Trp Lys Arg Glu Gly Arg Thr Ser Val Gly Phe 
    210                 215                 220                 


<210>  6467
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  6467

Met Ala Pro Gln Arg Arg Ala Ala Thr Lys Ala Pro Glu Gly Asn Gly 
1               5                   10                  15      


Ala Ala Glu Arg Arg Asn Arg Ser Ser Thr Lys Lys Asp Arg Ala Pro 
            20                  25                  30          


Arg Glu Val Gln Arg Leu Trp Gln Arg Pro Trp Leu Arg Thr Ala Gly 
        35                  40                  45              


Leu Gly Ala Gly Phe Val Leu Thr Ala Leu Leu Leu Trp Ser Ser Leu 
    50                  55                  60                  


Gly Ala Asp Asp Gly Val Ala Glu Val Leu Ala Arg Arg Gly Glu Val 
65                  70                  75                  80  


Val Ala Gly Arg Phe Ile Glu Val Pro Cys Ser Glu Asp Tyr Asp Ser 
                85                  90                  95      


His Arg Arg Phe Glu Gly Cys Thr Pro Arg Lys Cys Gly Arg Gly Val 
            100                 105                 110         


Thr Asp Val Val Ile Thr Arg Glu Glu Ala Glu Arg Ile Arg Ser Val 
        115                 120                 125             


Ala Glu Lys Gly Leu Ser Leu Gly Gly Ser Asp Gly Gly Ala Ser Ile 
    130                 135                 140                 


Leu Asp Leu His Ser Gly Ala Leu Ser Val Gly Lys His Phe Val Asn 
145                 150                 155                 160 


Leu Tyr Arg Tyr Phe Gly Asp Lys Ile Gln Asn Ile Phe Ser Glu Glu 
                165                 170                 175     


Asp Phe Arg Leu Tyr Arg Glu Val Arg Gln Lys Val Gln Leu Thr Ile 
            180                 185                 190         


Ala Glu Ala Phe Gly Ile Ser Ala Ser Ser Leu His Leu Thr Lys Pro 
        195                 200                 205             


Thr Phe Phe Ser Arg Ile Asn Ser Thr Glu Ala Arg Thr Ala His Asp 
    210                 215                 220                 


Glu Tyr Trp His Ala His Val Asp Lys Val Thr Tyr Gly Ser Phe Asp 
225                 230                 235                 240 


Tyr Thr Ser Leu Leu Tyr Leu Ser Asn Tyr Leu Glu Asp Phe Gly Gly 
                245                 250                 255     


Gly Arg Phe Met Phe Met Glu Glu Gly Ala Asn Lys Thr Val Glu Pro 
            260                 265                 270         


Arg Ala Gly Cys Phe Cys Phe Arg Met Met Ser Cys Gly Phe Gln Glu 
        275                 280                 285             


Val Asn Gly Pro Arg Ala Ser Glu Ala Ala Gly Ala Lys Ala Gly Val 
    290                 295                 300                 


Arg Cys Pro Pro Gly Thr His His Pro Pro Glu Arg Gly Glu Thr His 
305                 310                 315                 320 


Ala Ile Leu Glu Ala Glu Ser Ile Ala Tyr Cys 
                325                 330     


<210>  6468
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  6468

Met Glu Lys Trp Asn His Thr Ser Asn Asp Phe Ile Leu Leu Gly Leu 
1               5                   10                  15      


Leu Pro Pro Asn Gln Thr Gly Ile Phe Leu Leu Cys Leu Ile Ile Leu 
            20                  25                  30          


Ile Phe Phe Leu Ala Ser Val Gly Asn Ser Ala Met Ile His Leu Ile 
        35                  40                  45              


His Val Asp Pro Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln 
    50                  55                  60                  


Leu Ser Leu Met Asp Leu Met Tyr Ile Ser Thr Thr Val Pro Lys Met 
65                  70                  75                  80  


Ala Tyr Asn Phe Leu Ser Gly Gln Lys Gly Ile Ser Phe Leu Gly Cys 
                85                  90                  95      


Gly Val Gln Ser Phe Phe Phe Leu Thr Met Ala Cys Ser Glu Gly Leu 
            100                 105                 110         


Leu Leu Thr Ser Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys His Ser 
        115                 120                 125             


Leu Tyr Tyr Pro Ile Arg Met Ser Lys Met Met Cys Val Lys Met Ile 
    130                 135                 140                 


Gly Gly Ser Trp Thr Leu Gly Ser Ile Asn Ser Leu Ala His Thr Val 
145                 150                 155                 160 


Phe Ala Leu His Ile Pro Tyr Cys Arg Ser Arg Ala Ile Asp His Phe 
                165                 170                 175     


Phe Cys Asp Val Pro Ala Met Leu Leu Leu Ala Cys Thr Asp Thr Trp 
            180                 185                 190         


Val Tyr Glu Tyr Met Val Phe Val Ser Thr Ser Leu Phe Leu Leu Phe 
        195                 200                 205             


Pro Phe Ile Gly Ile Thr Ser Ser Cys Gly Arg Val Leu Phe Ala Val 
    210                 215                 220                 


Tyr His Met His Ser Lys Glu Gly Arg Lys Lys Ala Phe Thr Thr Ile 
225                 230                 235                 240 


Ser Thr His Leu Thr Val Val Ile Phe Tyr Tyr Ala Pro Phe Val Tyr 
                245                 250                 255     


Thr Tyr Leu Arg Pro Arg Asn Leu Arg Ser Pro Ala Glu Asp Lys Ile 
            260                 265                 270         


Leu Ala Val Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Ile Ile 
        275                 280                 285             


Tyr Ser Leu Arg Asn Lys Glu Val Leu Gly Ala Met Arg Arg Val Phe 
    290                 295                 300                 


Gly Ile Phe Ser Phe Leu Lys Glu 
305                 310         


<210>  6469
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  6469

Met Ser Gly Gly Arg Phe Asp Phe Asp Asp Gly Gly Ala Tyr Cys Gly 
1               5                   10                  15      


Gly Trp Glu Gly Gly Lys Ala His Gly His Gly Leu Cys Thr Gly Pro 
            20                  25                  30          


Lys Gly Gln Gly Glu Tyr Ser Gly Ser Trp Asn Phe Gly Phe Glu Val 
        35                  40                  45              


Ala Gly Val Tyr Thr Trp Pro Ser Gly Asn Thr Phe Glu Gly Tyr Trp 
    50                  55                  60                  


Ser Gln Gly Lys Arg His Gly Leu Gly Ile Glu Thr Lys Gly Arg Trp 
65                  70                  75                  80  


Leu Tyr Lys Gly Glu Trp Thr His Gly Phe Lys Gly Arg Tyr Gly Ile 
                85                  90                  95      


Arg Gln Ser Ser Ser Ser Gly Ala Lys Tyr Glu Gly Thr Trp Asn Asn 
            100                 105                 110         


Gly Leu Gln Asp Gly Tyr Gly Thr Glu Thr Tyr Ala Asp Gly Gly Met 
        115                 120                 125             


Cys 
    


<210>  6470
<211>  1011
<212>  PRT
<213>  Homo sapiens

<400>  6470

Met Ile Glu Asn Ser Met Phe Glu Glu Glu Pro Asp Val Val Asp Leu 
1               5                   10                  15      


Ala Lys Glu Pro Cys Leu His Pro Leu Glu Pro Asp Glu Val Glu Tyr 
            20                  25                  30          


Glu Pro Arg Gly Ser Arg Leu Leu Val Arg Gly Leu Gly Glu His Glu 
        35                  40                  45              


Met Glu Glu Asp Glu Glu Asp Tyr Glu Ser Ser Ala Lys Leu Leu Gly 
    50                  55                  60                  


Met Ser Phe Met Asn Arg Ser Ser Gly Leu Arg Asn Ser Ala Thr Gly 
65                  70                  75                  80  


Tyr Arg Gln Ser Pro Asp Gly Ala Cys Ser Val Pro Ser Ala Arg Thr 
                85                  90                  95      


Met Val Val Cys Ala Phe Val Ile Val Val Ala Val Ser Val Ile Met 
            100                 105                 110         


Val Ile Tyr Leu Leu Pro Arg Cys Thr Phe Thr Lys Glu Gly Cys His 
        115                 120                 125             


Lys Lys Asn Gln Ser Ile Gly Leu Ile Gln Pro Phe Ala Thr Asn Gly 
    130                 135                 140                 


Lys Leu Phe Pro Trp Ala Gln Ile Arg Leu Pro Thr Ala Val Val Pro 
145                 150                 155                 160 


Leu Arg Tyr Glu Leu Ser Leu His Pro Asn Leu Thr Ser Met Thr Phe 
                165                 170                 175     


Arg Gly Ser Val Thr Ile Ser Val Gln Ala Leu Gln Val Thr Trp Asn 
            180                 185                 190         


Ile Ile Leu His Ser Thr Gly His Asn Ile Ser Arg Val Thr Phe Met 
        195                 200                 205             


Ser Ala Val Ser Ser Gln Glu Lys Gln Ala Glu Ile Leu Glu Tyr Ala 
    210                 215                 220                 


Tyr His Gly Gln Ile Ala Ile Val Ala Pro Glu Ala Leu Leu Ala Gly 
225                 230                 235                 240 


His Asn Tyr Thr Leu Lys Ile Glu Tyr Ser Ala Asn Ile Ser Ser Ser 
                245                 250                 255     


Tyr Tyr Gly Phe Tyr Gly Phe Ser Tyr Thr Asp Glu Ser Asn Glu Lys 
            260                 265                 270         


Lys Tyr Phe Ala Ala Thr Gln Phe Glu Pro Leu Ala Ala Arg Ser Ala 
        275                 280                 285             


Phe Pro Cys Phe Asp Glu Pro Ala Phe Lys Ala Thr Phe Ile Ile Lys 
    290                 295                 300                 


Ile Ile Arg Asp Glu Gln Tyr Thr Ala Leu Ser Asn Met Pro Lys Lys 
305                 310                 315                 320 


Ser Ser Val Val Leu Asp Asp Gly Leu Val Gln Asp Glu Phe Ser Glu 
                325                 330                 335     


Ser Val Lys Met Ser Thr Tyr Leu Val Ala Phe Ile Val Gly Glu Met 
            340                 345                 350         


Lys Asn Leu Ser Gln Asp Val Asn Gly Thr Leu Val Ser Ile Tyr Ala 
        355                 360                 365             


Val Pro Glu Lys Ile Gly Gln Val His Tyr Ala Leu Glu Thr Thr Val 
    370                 375                 380                 


Lys Leu Leu Glu Phe Phe Gln Asn Tyr Phe Glu Ile Gln Tyr Pro Leu 
385                 390                 395                 400 


Lys Lys Leu Asp Leu Val Ala Ile Pro Asp Phe Glu Ala Gly Ala Met 
                405                 410                 415     


Glu Asn Trp Gly Leu Leu Thr Phe Arg Glu Glu Thr Leu Leu Tyr Asp 
            420                 425                 430         


Ser Asn Thr Ser Ser Met Ala Asp Arg Lys Leu Val Thr Lys Ile Ile 
        435                 440                 445             


Ala His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr Met Lys 
    450                 455                 460                 


Trp Trp Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Thr Phe Met Glu 
465                 470                 475                 480 


Tyr Phe Ser Leu Glu Lys Ile Phe Lys Glu Leu Ser Ser Tyr Glu Asp 
                485                 490                 495     


Phe Leu Asp Ala Arg Phe Lys Thr Met Lys Lys Asp Ser Leu Asn Ser 
            500                 505                 510         


Ser His Pro Ile Ser Ser Ser Val Gln Ser Ser Glu Gln Ile Glu Glu 
        515                 520                 525             


Met Phe Asp Ser Leu Ser Tyr Phe Lys Gly Ser Ser Leu Leu Leu Met 
    530                 535                 540                 


Leu Lys Thr Tyr Leu Ser Glu Asp Val Phe Gln His Ala Val Val Leu 
545                 550                 555                 560 


Tyr Leu His Asn His Ser Tyr Ala Ser Ile Gln Ser Asp Asp Leu Trp 
                565                 570                 575     


Asp Ser Phe Asn Glu Val Thr Asn Gln Thr Leu Asp Val Lys Arg Met 
            580                 585                 590         


Met Lys Thr Trp Thr Leu Gln Lys Gly Phe Pro Leu Val Thr Val Gln 
        595                 600                 605             


Lys Lys Gly Lys Glu Leu Phe Ile Gln Gln Glu Arg Phe Phe Leu Asn 
    610                 615                 620                 


Met Lys Pro Glu Ile Gln Pro Ser Asp Thr Ser Tyr Leu Trp His Ile 
625                 630                 635                 640 


Pro Leu Ser Tyr Val Thr Glu Gly Arg Asn Tyr Ser Lys Tyr Gln Ser 
                645                 650                 655     


Val Ser Leu Leu Asp Lys Lys Ser Gly Val Ile Asn Leu Thr Glu Glu 
            660                 665                 670         


Val Leu Trp Val Lys Val Asn Ile Asn Met Asn Gly Tyr Tyr Ile Val 
        675                 680                 685             


His Tyr Ala Asp Asp Asp Trp Glu Ala Leu Ile His Gln Leu Lys Ile 
    690                 695                 700                 


Asn Pro Tyr Val Leu Ser Asp Lys Asp Arg Ala Asn Leu Ile Asn Asn 
705                 710                 715                 720 


Ile Phe Glu Leu Ala Gly Leu Gly Lys Val Pro Leu Lys Arg Ala Phe 
                725                 730                 735     


Asp Leu Ile Asn Tyr Leu Gly Asn Glu Asn His Thr Ala Pro Ile Thr 
            740                 745                 750         


Glu Ala Leu Phe Gln Thr Asp Leu Ile Tyr Asn Leu Leu Glu Lys Leu 
        755                 760                 765             


Gly Tyr Met Asp Leu Ala Ser Arg Leu Val Thr Arg Val Phe Lys Leu 
    770                 775                 780                 


Leu Gln Asn Gln Ile Gln Gln Gln Thr Trp Thr Asp Glu Gly Thr Pro 
785                 790                 795                 800 


Ser Met Arg Glu Leu Arg Ser Ala Leu Leu Glu Phe Ala Cys Thr His 
                805                 810                 815     


Asn Leu Gly Asn Cys Ser Thr Thr Ala Met Lys Leu Phe Asp Asp Trp 
            820                 825                 830         


Met Ala Ser Asn Gly Thr Gln Ser Leu Pro Thr Asp Val Met Thr Thr 
        835                 840                 845             


Val Phe Lys Val Gly Ala Lys Thr Asp Lys Gly Trp Ser Phe Leu Leu 
    850                 855                 860                 


Gly Lys Tyr Ile Ser Ile Gly Ser Glu Ala Glu Lys Asn Lys Ile Leu 
865                 870                 875                 880 


Glu Ala Leu Ala Ser Ser Glu Asp Val Arg Lys Leu Tyr Trp Leu Met 
                885                 890                 895     


Lys Ser Ser Leu Asn Gly Asp Asn Phe Arg Thr Gln Lys Leu Ser Phe 
            900                 905                 910         


Ile Ile Arg Thr Val Gly Arg His Phe Pro Gly His Leu Leu Ala Trp 
        915                 920                 925             


Asp Phe Val Lys Glu Asn Trp Asn Lys Leu Val Gln Lys Phe Pro Leu 
    930                 935                 940                 


Gly Ser Tyr Thr Ile Gln Asn Ile Val Ala Gly Ser Thr Tyr Leu Phe 
945                 950                 955                 960 


Ser Thr Lys Thr His Leu Ser Glu Val Gln Ala Phe Phe Glu Asn Gln 
                965                 970                 975     


Ser Glu Ala Thr Phe Arg Leu Arg Cys Val Gln Glu Ala Leu Glu Val 
            980                 985                 990         


Ile Gln Leu Asn Ile Gln Trp Met  Glu Lys Asn Leu Lys  Ser Leu Thr 
        995                 1000                 1005             


Trp Trp  Leu 
    1010     


<210>  6471
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  6471

Met Ala Trp Pro Lys Leu Pro Ala Pro Trp Leu Leu Leu Cys Thr Trp 
1               5                   10                  15      


Leu Pro Ala Gly Cys Leu Ser Leu Leu Val Thr Val Gln His Thr Glu 
            20                  25                  30          


Arg Tyr Val Thr Leu Phe Ala Ser Ile Ile Leu Lys Cys Asp Tyr Thr 
        35                  40                  45              


Thr Ser Ala Gln Leu Gln Asp Val Val Val Thr Trp Arg Phe Lys Ser 
    50                  55                  60                  


Phe Cys Lys Asp Pro Ile Phe Asp Tyr Tyr Ser Ala Ser Tyr Gln Ala 
65                  70                  75                  80  


Ala Leu Ser Leu Gly Gln Asp Pro Ser Asn Asp Cys Asn Asp Asn Gln 
                85                  90                  95      


Arg Glu Val Arg Ile Val Ala Gln Arg Arg Gly Gln Asn Glu Pro Val 
            100                 105                 110         


Leu Gly Val Asp Tyr Arg Gln Arg Lys Ile Thr Ile Gln Asn Arg Ala 
        115                 120                 125             


Asp Leu Val Ile Asn Glu Val Met Trp Trp Asp His Gly Val Tyr Tyr 
    130                 135                 140                 


Cys Thr Ile Glu Ala Pro Gly Asp Thr Ser Gly Asp Pro Asp Lys Glu 
145                 150                 155                 160 


Val Lys Leu Ile Val Leu His Trp Leu Thr Val Ile Phe Ile Ile Leu 
                165                 170                 175     


Gly Ala Leu Leu Leu Leu Leu Leu Ile Gly Val Cys Trp Cys Gln Cys 
            180                 185                 190         


Cys Pro Gln Tyr Cys Cys Cys Tyr Ile Arg Cys Pro Cys Cys Pro Ala 
        195                 200                 205             


His Cys Cys Cys Pro Glu Glu Asp Leu Ser Leu Pro Ser Ser Leu Pro 
    210                 215                 220                 


Gln Met Pro Met Thr Gln Thr Thr Asn Gln Pro Pro Ile Ala Asn Gly 
225                 230                 235                 240 


Val Leu Glu Tyr Leu Glu Lys Glu Leu Arg Asn Leu Asn Leu Ala Gln 
                245                 250                 255     


Pro Leu Pro Pro Asp Leu Lys Gly Arg Phe Gly His Pro Cys Ser Met 
            260                 265                 270         


Leu Ser Ser Leu Gly Ser Glu Val Val Glu Arg Arg Ile Ile His Leu 
        275                 280                 285             


Pro Pro Leu Ile Arg Asp Leu Ser Ser Ser Arg Arg Thr Ser Asp Ser 
    290                 295                 300                 


Leu His Gln Gln Trp Leu Thr Pro Ile Pro Ser Arg Pro Trp Asp Leu 
305                 310                 315                 320 


Arg Glu Gly Arg Ser His His His Tyr Pro Asp Phe His Gln Glu Leu 
                325                 330                 335     


Gln Asp Arg Gly Pro Lys Ser Trp Ala Leu Glu Arg Arg Glu Leu Asp 
            340                 345                 350         


Pro Ser Trp Ser Gly Arg His Arg Ser Ser Arg Leu Asn Gly Ser Pro 
        355                 360                 365             


Ile His Trp Ser Asp Arg Asp Ser Leu Ser Asp Val Pro Ser Ser Ser 
    370                 375                 380                 


Glu Ala Arg Trp Arg Pro Ser His Pro Pro Phe Arg Ser Arg Cys Gln 
385                 390                 395                 400 


Glu Arg Pro Arg Arg Pro Ser Pro Arg Glu Ser Thr Gln Arg His Gly 
                405                 410                 415     


Arg Arg Arg Arg His Arg Ser Tyr Ser Pro Pro Leu Pro Ser Gly Leu 
            420                 425                 430         


Ser Ser Trp Ser Ser Glu Glu Asp Lys Glu Arg Gln Pro Gln Ser Trp 
        435                 440                 445             


Arg Ala His Arg Arg Gly Ser His Ser Pro His Trp Pro Glu Glu Lys 
    450                 455                 460                 


Pro Pro Ser Tyr Arg Ser Leu Asp Ile Thr Pro Gly Lys Asn Ser Arg 
465                 470                 475                 480 


Lys Lys Gly Ser Val Glu Arg Arg Ser Glu Lys Asp Ser Ser His Ser 
                485                 490                 495     


Gly Arg Ser Val Val Ile 
            500         


<210>  6472
<211>  1551
<212>  PRT
<213>  Homo sapiens

<400>  6472

Met Gly Phe Cys Leu Ala Leu Ala Trp Thr Leu Leu Val Gly Ala Trp 
1               5                   10                  15      


Thr Pro Leu Gly Ala Gln Asn Pro Ile Ser Trp Glu Val Gln Arg Phe 
            20                  25                  30          


Asp Gly Trp Tyr Asn Asn Leu Met Glu His Arg Trp Gly Ser Lys Gly 
        35                  40                  45              


Ser Arg Leu Gln Arg Leu Val Pro Ala Ser Tyr Ala Asp Gly Val Tyr 
    50                  55                  60                  


Gln Pro Leu Gly Glu Pro His Leu Pro Asn Pro Arg Asp Leu Ser Asn 
65                  70                  75                  80  


Thr Ile Ser Arg Gly Pro Ala Gly Leu Ala Ser Leu Arg Asn Arg Thr 
                85                  90                  95      


Val Leu Gly Val Phe Phe Gly Tyr His Val Leu Ser Asp Leu Val Ser 
            100                 105                 110         


Val Glu Thr Pro Gly Cys Pro Ala Glu Phe Leu Asn Ile Arg Ile Pro 
        115                 120                 125             


Pro Gly Asp Pro Met Phe Asp Pro Asp Gln Arg Gly Asp Val Val Leu 
    130                 135                 140                 


Pro Phe Gln Arg Ser Arg Trp Asp Pro Glu Thr Gly Arg Ser Pro Ser 
145                 150                 155                 160 


Asn Pro Arg Asp Pro Ala Asn Gln Val Thr Gly Trp Leu Asp Gly Ser 
                165                 170                 175     


Ala Ile Tyr Gly Ser Ser His Ser Trp Ser Asp Ala Leu Arg Ser Phe 
            180                 185                 190         


Ser Arg Gly Gln Leu Ala Ser Gly Pro Asp Pro Ala Phe Pro Arg Asp 
        195                 200                 205             


Ser Gln Asn Pro Leu Leu Met Trp Ala Ala Pro Asp Pro Ala Thr Gly 
    210                 215                 220                 


Gln Asn Gly Pro Arg Gly Leu Tyr Ala Phe Gly Ala Glu Arg Gly Asn 
225                 230                 235                 240 


Arg Glu Pro Phe Leu Gln Ala Leu Gly Leu Leu Trp Phe Arg Tyr His 
                245                 250                 255     


Asn Leu Trp Ala Gln Arg Leu Ala Arg Gln His Pro Asp Trp Glu Asp 
            260                 265                 270         


Glu Glu Leu Phe Gln His Ala Arg Lys Arg Val Ile Ala Thr Tyr Gln 
        275                 280                 285             


Asn Ile Ala Val Tyr Glu Trp Leu Pro Ser Phe Leu Gln Lys Thr Leu 
    290                 295                 300                 


Pro Glu Tyr Thr Gly Tyr Arg Pro Phe Leu Asp Pro Ser Ile Ser Ser 
305                 310                 315                 320 


Glu Phe Val Ala Ala Ser Glu Gln Phe Leu Ser Thr Met Val Pro Pro 
                325                 330                 335     


Gly Val Tyr Met Arg Asn Ala Ser Cys His Phe Gln Gly Val Ile Asn 
            340                 345                 350         


Arg Asn Ser Ser Val Ser Arg Ala Leu Arg Val Cys Asn Ser Tyr Trp 
        355                 360                 365             


Ser Arg Glu His Pro Ser Leu Gln Ser Ala Glu Asp Val Asp Ala Leu 
    370                 375                 380                 


Leu Leu Gly Met Ala Ser Gln Ile Ala Glu Arg Glu Asp His Val Leu 
385                 390                 395                 400 


Val Glu Asp Val Arg Asp Phe Trp Pro Gly Pro Leu Lys Phe Ser Arg 
                405                 410                 415     


Thr Asp His Leu Ala Ser Cys Leu Gln Arg Gly Arg Asp Leu Gly Leu 
            420                 425                 430         


Pro Ser Tyr Thr Lys Ala Arg Ala Ala Leu Gly Leu Ser Pro Ile Thr 
        435                 440                 445             


Arg Trp Gln Asp Ile Asn Pro Ala Leu Ser Arg Ser Asn Asp Thr Val 
    450                 455                 460                 


Leu Glu Ala Thr Ala Ala Leu Tyr Asn Gln Asp Leu Ser Trp Leu Glu 
465                 470                 475                 480 


Leu Leu Pro Gly Gly Leu Leu Glu Ser His Arg Asp Pro Gly Pro Leu 
                485                 490                 495     


Phe Ser Thr Ile Val Leu Glu Gln Phe Val Arg Leu Arg Asp Gly Asp 
            500                 505                 510         


Arg Tyr Trp Phe Glu Asn Thr Arg Asn Gly Leu Phe Ser Lys Lys Glu 
        515                 520                 525             


Ile Glu Glu Ile Arg Asn Thr Thr Leu Gln Asp Val Leu Val Ala Val 
    530                 535                 540                 


Ile Asn Ile Asp Pro Ser Ala Leu Gln Pro Asn Val Phe Val Trp His 
545                 550                 555                 560 


Lys Gly Asp Pro Cys Pro Gln Pro Arg Gln Leu Ser Thr Glu Gly Leu 
                565                 570                 575     


Pro Ala Cys Ala Pro Ser Val Val Arg Asp Tyr Phe Glu Gly Ser Gly 
            580                 585                 590         


Phe Gly Phe Gly Val Thr Ile Gly Thr Leu Cys Cys Phe Pro Leu Val 
        595                 600                 605             


Ser Leu Leu Ser Ala Trp Ile Val Ala Arg Leu Arg Met Arg Asn Phe 
    610                 615                 620                 


Lys Arg Leu Gln Gly Gln Asp Arg Gln Ser Ile Val Ser Glu Lys Leu 
625                 630                 635                 640 


Val Gly Gly Met Glu Ala Leu Glu Trp Gln Gly His Lys Glu Pro Cys 
                645                 650                 655     


Arg Pro Val Leu Val Tyr Leu Gln Pro Gly Gln Ile Arg Val Val Asp 
            660                 665                 670         


Gly Arg Leu Thr Val Leu Arg Thr Ile Gln Leu Gln Pro Pro Gln Lys 
        675                 680                 685             


Val Asn Phe Val Leu Ser Ser Asn Arg Gly Arg Arg Thr Leu Leu Leu 
    690                 695                 700                 


Lys Ile Pro Lys Glu Tyr Asp Leu Val Leu Leu Phe Asn Leu Glu Glu 
705                 710                 715                 720 


Glu Arg Gln Ala Leu Val Glu Asn Leu Arg Gly Ala Leu Lys Glu Ser 
                725                 730                 735     


Gly Leu Ser Ile Gln Glu Trp Glu Leu Arg Glu Gln Glu Leu Met Arg 
            740                 745                 750         


Ala Ala Val Thr Arg Glu Gln Arg Arg His Leu Leu Glu Thr Phe Phe 
        755                 760                 765             


Arg His Leu Phe Ser Gln Val Leu Asp Ile Asn Gln Ala Asp Ala Gly 
    770                 775                 780                 


Thr Leu Pro Leu Asp Ser Ser Gln Lys Val Arg Glu Ala Leu Thr Cys 
785                 790                 795                 800 


Glu Leu Ser Arg Ala Glu Phe Ala Glu Ser Leu Gly Leu Lys Pro Gln 
                805                 810                 815     


Asp Met Phe Val Glu Ser Met Phe Ser Leu Ala Asp Lys Asp Gly Asn 
            820                 825                 830         


Gly Tyr Leu Ser Phe Arg Glu Phe Leu Asp Ile Leu Val Val Phe Met 
        835                 840                 845             


Lys Gly Ser Pro Glu Glu Lys Ser Arg Leu Met Phe Arg Met Tyr Asp 
    850                 855                 860                 


Phe Asp Gly Asn Gly Leu Ile Ser Lys Asp Glu Phe Ile Arg Met Leu 
865                 870                 875                 880 


Arg Ser Phe Ile Glu Ile Ser Asn Asn Cys Leu Ser Lys Ala Gln Leu 
                885                 890                 895     


Ala Glu Val Val Glu Ser Met Phe Arg Glu Ser Gly Phe Gln Asp Lys 
            900                 905                 910         


Glu Glu Leu Thr Trp Glu Asp Phe His Phe Met Leu Arg Asp His Asn 
        915                 920                 925             


Ser Glu Leu Arg Phe Thr Gln Leu Cys Val Lys Gly Val Glu Val Pro 
    930                 935                 940                 


Glu Val Ile Lys Asp Leu Cys Arg Arg Ala Ser Tyr Ile Ser Gln Asp 
945                 950                 955                 960 


Met Ile Cys Pro Ser Pro Arg Val Ser Ala Arg Cys Ser Arg Ser Asp 
                965                 970                 975     


Ile Glu Thr Glu Leu Thr Pro Gln Arg Leu Gln Cys Pro Met Asp Thr 
            980                 985                 990         


Asp Pro Pro Gln Glu Ile Arg Arg  Arg Phe Gly Lys Lys  Val Thr Ser 
        995                 1000                 1005             


Phe Gln  Pro Leu Leu Phe Thr  Glu Ala His Arg Glu  Lys Phe Gln 
    1010                 1015                 1020             


Arg Ser  Cys Leu His Gln Thr  Val Gln Gln Phe Lys  Arg Phe Ile 
    1025                 1030                 1035             


Glu Asn  Tyr Arg Arg His Ile  Gly Cys Val Ala Val  Phe Tyr Ala 
    1040                 1045                 1050             


Ile Ala  Gly Gly Leu Phe Leu  Glu Arg Ala Tyr Tyr  Tyr Ala Phe 
    1055                 1060                 1065             


Ala Ala  His His Thr Gly Ile  Thr Asp Thr Thr Arg  Val Gly Ile 
    1070                 1075                 1080             


Ile Leu  Ser Arg Gly Thr Ala  Ala Ser Ile Ser Phe  Met Phe Ser 
    1085                 1090                 1095             


Tyr Ile  Leu Leu Thr Met Cys  Arg Asn Leu Ile Thr  Phe Leu Arg 
    1100                 1105                 1110             


Glu Thr  Phe Leu Asn Arg Tyr  Val Pro Phe Asp Ala  Ala Val Asp 
    1115                 1120                 1125             


Phe His  Arg Leu Ile Ala Ser  Thr Ala Ile Val Leu  Thr Val Leu 
    1130                 1135                 1140             


His Ser  Val Gly His Val Val  Asn Val Tyr Leu Phe  Ser Ile Ser 
    1145                 1150                 1155             


Pro Leu  Ser Val Leu Ser Cys  Leu Phe Pro Gly Leu  Phe His Asp 
    1160                 1165                 1170             


Asp Gly  Ser Glu Leu Pro Gln  Lys Tyr Tyr Trp Trp  Phe Phe Gln 
    1175                 1180                 1185             


Thr Val  Pro Gly Leu Thr Gly  Val Val Leu Leu Leu  Ile Leu Ala 
    1190                 1195                 1200             


Ile Met  Tyr Val Phe Ala Ser  His His Phe Arg Arg  Arg Ser Phe 
    1205                 1210                 1215             


Arg Gly  Phe Trp Leu Thr His  His Leu Tyr Ile Leu  Leu Tyr Val 
    1220                 1225                 1230             


Leu Leu  Ile Ile His Gly Ser  Phe Ala Leu Ile Gln  Leu Pro Arg 
    1235                 1240                 1245             


Phe His  Ile Phe Phe Leu Val  Pro Ala Ile Ile Tyr  Gly Gly Asp 
    1250                 1255                 1260             


Lys Leu  Val Ser Leu Ser Arg  Lys Lys Val Glu Ile  Ser Val Val 
    1265                 1270                 1275             


Lys Ala  Glu Leu Leu Pro Ser  Gly Val Thr His Leu  Arg Phe Gln 
    1280                 1285                 1290             


Arg Pro  Gln Gly Phe Glu Tyr  Lys Ser Gly Gln Trp  Val Arg Ile 
    1295                 1300                 1305             


Ala Cys  Leu Ala Leu Gly Thr  Thr Glu Tyr His Pro  Phe Thr Leu 
    1310                 1315                 1320             


Thr Ser  Ala Pro His Glu Asp  Thr Leu Ser Leu His  Ile Arg Ala 
    1325                 1330                 1335             


Ala Gly  Pro Trp Thr Thr Arg  Leu Arg Glu Ile Tyr  Ser Ala Pro 
    1340                 1345                 1350             


Thr Gly  Asp Arg Cys Ala Arg  Tyr Pro Lys Leu Tyr  Leu Asp Gly 
    1355                 1360                 1365             


Pro Phe  Gly Glu Gly His Gln  Glu Trp His Lys Phe  Glu Val Ser 
    1370                 1375                 1380             


Val Leu  Val Gly Gly Gly Ile  Gly Val Thr Pro Phe  Ala Ser Ile 
    1385                 1390                 1395             


Leu Lys  Asp Leu Val Phe Lys  Ser Ser Val Ser Cys  Gln Val Phe 
    1400                 1405                 1410             


Cys Lys  Lys Ile Tyr Phe Ile  Trp Val Thr Arg Thr  Gln Arg Gln 
    1415                 1420                 1425             


Phe Glu  Trp Leu Ala Asp Ile  Ile Arg Glu Val Glu  Glu Asn Asp 
    1430                 1435                 1440             


His Gln  Asp Leu Val Ser Val  His Ile Tyr Ile Thr  Gln Leu Ala 
    1445                 1450                 1455             


Glu Lys  Phe Asp Leu Arg Thr  Thr Met Leu Tyr Ile  Cys Glu Arg 
    1460                 1465                 1470             


His Phe  Gln Lys Val Leu Asn  Arg Ser Leu Phe Thr  Gly Leu Arg 
    1475                 1480                 1485             


Ser Ile  Thr His Phe Gly Arg  Pro Pro Phe Glu Pro  Phe Phe Asn 
    1490                 1495                 1500             


Ser Leu  Gln Glu Val His Pro  Gln Val Arg Lys Ile  Gly Val Phe 
    1505                 1510                 1515             


Ser Cys  Gly Pro Pro Gly Met  Thr Lys Asn Val Glu  Lys Ala Cys 
    1520                 1525                 1530             


Gln Leu  Ile Asn Arg Gln Asp  Arg Thr His Phe Ser  His His Tyr 
    1535                 1540                 1545             


Glu Asn  Phe 
    1550     


<210>  6473
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  6473

Met Ala Ala Asp Leu Gly Pro Trp Asn Asp Thr Ile Asn Gly Thr Trp 
1               5                   10                  15      


Asp Gly Asp Glu Leu Gly Tyr Arg Cys Arg Phe Asn Glu Asp Phe Lys 
            20                  25                  30          


Tyr Val Leu Leu Pro Val Ser Tyr Gly Val Val Cys Val Leu Gly Leu 
        35                  40                  45              


Cys Leu Asn Ala Val Ala Leu Tyr Ile Phe Leu Cys Arg Leu Lys Thr 
    50                  55                  60                  


Trp Asn Ala Ser Thr Thr Tyr Met Phe His Leu Ala Val Ser Asp Ala 
65                  70                  75                  80  


Leu Tyr Ala Ala Ser Leu Pro Leu Leu Val Tyr Tyr Tyr Ala Arg Gly 
                85                  90                  95      


Asp His Trp Pro Phe Ser Thr Val Leu Cys Lys Leu Val Arg Phe Leu 
            100                 105                 110         


Phe Tyr Thr Asn Leu Tyr Cys Ser Ile Leu Phe Leu Thr Cys Ile Ser 
        115                 120                 125             


Val His Arg Cys Leu Gly Val Leu Arg Pro Leu Arg Ser Leu Arg Trp 
    130                 135                 140                 


Gly Arg Ala Arg Tyr Ala Arg Arg Val Ala Gly Ala Val Trp Val Leu 
145                 150                 155                 160 


Val Leu Ala Cys Gln Ala Pro Val Leu Tyr Phe Val Thr Thr Ser Ala 
                165                 170                 175     


Arg Gly Gly Arg Val Thr Cys His Asp Thr Ser Ala Pro Glu Leu Phe 
            180                 185                 190         


Ser Arg Phe Val Ala Tyr Ser Ser Val Met Leu Gly Leu Leu Phe Ala 
        195                 200                 205             


Val Pro Phe Ala Val Ile Leu Val Cys Tyr Val Leu Met Ala Arg Arg 
    210                 215                 220                 


Leu Leu Lys Pro Ala Tyr Gly Thr Ser Gly Gly Leu Pro Arg Ala Lys 
225                 230                 235                 240 


Arg Lys Ser Val Arg Thr Ile Ala Val Val Leu Ala Val Phe Ala Leu 
                245                 250                 255     


Cys Phe Leu Pro Phe His Val Thr Arg Thr Leu Tyr Tyr Ser Phe Arg 
            260                 265                 270         


Ser Leu Asp Leu Ser Cys His Thr Leu Asn Ala Ile Asn Met Ala Tyr 
        275                 280                 285             


Lys Val Thr Arg Pro Leu Ala Ser Ala Asn Ser Cys Leu Asp Pro Val 
    290                 295                 300                 


Leu Tyr Phe Leu Ala Gly Gln Arg Leu Val Arg Phe Ala Arg Asp Ala 
305                 310                 315                 320 


Lys Pro Pro Thr Gly Pro Ser Pro Ala Thr Pro Ala Arg Arg Arg Leu 
                325                 330                 335     


Gly Leu Arg Arg Ser Asp Arg Thr Asp Met Gln Arg Ile Glu Asp Val 
            340                 345                 350         


Leu Gly Ser Ser Glu Asp Ser Arg Arg Thr Glu Ser Thr Pro Ala Gly 
        355                 360                 365             


Ser Glu Asn Thr Lys Asp Ile Arg Leu 
    370                 375         


<210>  6474
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  6474

Met Ala Ala Asp Leu Gly Pro Trp Asn Asp Thr Ile Asn Gly Thr Trp 
1               5                   10                  15      


Asp Gly Asp Glu Leu Gly Tyr Arg Cys Arg Phe Asn Glu Asp Phe Lys 
            20                  25                  30          


Tyr Val Leu Leu Pro Val Ser Tyr Gly Val Val Cys Val Leu Gly Leu 
        35                  40                  45              


Cys Leu Asn Ala Val Ala Leu Tyr Ile Phe Leu Cys Arg Leu Lys Thr 
    50                  55                  60                  


Trp Asn Ala Ser Thr Thr Tyr Met Phe His Leu Ala Val Ser Asp Ala 
65                  70                  75                  80  


Leu Tyr Ala Ala Ser Leu Pro Leu Leu Val Tyr Tyr Tyr Ala Arg Gly 
                85                  90                  95      


Asp His Trp Pro Phe Ser Thr Val Leu Cys Lys Leu Val Arg Phe Leu 
            100                 105                 110         


Phe Tyr Thr Asn Leu Tyr Cys Ser Ile Leu Phe Leu Thr Cys Ile Ser 
        115                 120                 125             


Val His Arg Cys Leu Gly Val Leu Arg Pro Leu Arg Ser Leu Arg Trp 
    130                 135                 140                 


Gly Arg Ala Arg Tyr Ala Arg Arg Val Ala Gly Ala Val Trp Val Leu 
145                 150                 155                 160 


Val Leu Ala Cys Gln Ala Pro Val Leu Tyr Phe Val Thr Thr Ser Ala 
                165                 170                 175     


Arg Gly Gly Arg Val Thr Cys His Asp Thr Ser Ala Pro Glu Leu Phe 
            180                 185                 190         


Ser Arg Phe Val Ala Tyr Ser Ser Val Met Leu Gly Leu Leu Phe Ala 
        195                 200                 205             


Val Pro Phe Ala Val Ile Leu Val Cys Tyr Val Leu Met Ala Arg Arg 
    210                 215                 220                 


Leu Leu Lys Pro Ala Tyr Gly Thr Ser Gly Gly Leu Pro Arg Ala Lys 
225                 230                 235                 240 


Arg Lys Ser Val Arg Thr Ile Ala Val Val Leu Ala Val Phe Ala Leu 
                245                 250                 255     


Cys Phe Leu Pro Phe His Val Thr Arg Thr Leu Tyr Tyr Ser Phe Arg 
            260                 265                 270         


Ser Leu Asp Leu Ser Cys His Thr Leu Asn Ala Ile Asn Met Ala Tyr 
        275                 280                 285             


Lys Val Thr Arg Pro Leu Ala Ser Ala Asn Ser Cys Leu Asp Pro Val 
    290                 295                 300                 


Leu Tyr Phe Leu Ala Gly Gln Arg Leu Val Arg Phe Ala Arg Asp Ala 
305                 310                 315                 320 


Lys Pro Pro Thr Gly Pro Ser Pro Ala Thr Pro Ala Arg Arg Arg Leu 
                325                 330                 335     


Gly Leu Arg Arg Ser Asp Arg Thr Asp Met Gln Arg Ile Glu Asp Val 
            340                 345                 350         


Leu Gly Ser Ser Glu Asp Ser Arg Arg Thr Glu Ser Thr Pro Ala Gly 
        355                 360                 365             


Ser Glu Asn Thr Lys Asp Ile Arg Leu 
    370                 375         


<210>  6475
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  6475

Met Val Cys Arg Glu Gln Leu Ser Lys Asn Gln Val Lys Trp Val Phe 
1               5                   10                  15      


Ala Gly Ile Thr Cys Val Ser Val Val Val Ile Ala Ala Ile Val Leu 
            20                  25                  30          


Ala Ile Thr Leu Arg Arg Pro Gly Cys Glu Leu Glu Ala Cys Ser Pro 
        35                  40                  45              


Asp Ala Asp Met Leu Asp Tyr Leu Leu Ser Leu Gly Gln Ile Ser Arg 
    50                  55                  60                  


Arg Asp Ala Leu Glu Val Thr Trp Tyr His Ala Ala Asn Ser Lys Lys 
65                  70                  75                  80  


Ala Met Thr Ala Ala Leu Asn Ser Asn Ile Thr Val Leu Glu Ala Asp 
                85                  90                  95      


Val Asn Val Glu Gly Leu Gly Thr Ala Asn Glu Thr Gly Val Pro Ile 
            100                 105                 110         


Met Ala His Pro Pro Thr Ile Tyr Ser Asp Asn Thr Leu Glu Gln Trp 
        115                 120                 125             


Leu Asp Ala Val Leu Gly Ser Ser Gln Lys Gly Ile Lys Leu Asp Phe 
    130                 135                 140                 


Lys Asn Ile Lys Ala Val Gly Pro Ser Leu Asp Leu Leu Arg Gln Leu 
145                 150                 155                 160 


Thr Glu Glu Gly Lys Val Arg Arg Pro Ile Trp Ile Asn Ala Asp Ile 
                165                 170                 175     


Leu Lys Gly Pro Asn Met Leu Ile Ser Thr Glu Val Asn Ala Thr Gln 
            180                 185                 190         


Phe Leu Ala Leu Val Gln Glu Lys Tyr Pro Lys Ala Thr Leu Ser Pro 
        195                 200                 205             


Gly Trp Thr Thr Phe Tyr Met Ser Thr Ser Pro Asn Arg Thr Tyr Thr 
    210                 215                 220                 


Gln Ala Met Val Glu Lys Met His Glu Leu Val Gly Gly Val Pro Gln 
225                 230                 235                 240 


Arg Val Thr Phe Pro Val Arg Ser Ser Met Val Arg Ala Ala Trp Pro 
                245                 250                 255     


His Phe Ser Trp Leu Leu Ser Gln Ser Glu Arg Tyr Ser Leu Thr Leu 
            260                 265                 270         


Trp Gln Ala Ala Ser Asp Pro Met Ser Val Glu Asp Leu Leu Tyr Val 
        275                 280                 285             


Arg Asp Asn Thr Ala Val His Gln Val Tyr Tyr Asp Ile Phe Glu Pro 
    290                 295                 300                 


Leu Leu Ser Gln Phe Lys Gln Leu Ala Leu Asn Ala Thr Arg Lys Pro 
305                 310                 315                 320 


Met Tyr Tyr Thr Gly Gly Ser Leu Ile Pro Leu Leu Gln Leu Pro Gly 
                325                 330                 335     


Asp Asp Gly Leu Asn Val Glu Trp Leu Val Pro Asp Val Gln Gly Ser 
            340                 345                 350         


Gly Lys Thr Ala Thr Met Thr Leu Pro Asp Thr Glu Gly Met Ile Leu 
        355                 360                 365             


Leu Asn Thr Gly Leu Glu Gly Thr Val Ala Glu Asn Pro Val Pro Ile 
    370                 375                 380                 


Val His Thr Pro Ser Gly Asn Ile Leu Thr Leu Glu Ser Cys Leu Gln 
385                 390                 395                 400 


Gln Leu Ala Thr His Pro Gly His Trp Gly Ile His Leu Gln Ile Ala 
                405                 410                 415     


Glu Pro Ala Ala Leu Arg Pro Ser Leu Ala Leu Leu Ala Arg Leu Ser 
            420                 425                 430         


Ser Leu Gly Leu Leu His Trp Pro Val Trp Val Gly Ala Lys Ile Ser 
        435                 440                 445             


His Gly Ser Phe Ser Val Pro Gly His Val Ala Gly Arg Glu Leu Leu 
    450                 455                 460                 


Thr Ala Val Ala Glu Val Phe Pro His Val Thr Val Ala Pro Gly Trp 
465                 470                 475                 480 


Pro Glu Glu Val Leu Gly Ser Gly Tyr Arg Glu Gln Leu Leu Thr Asp 
                485                 490                 495     


Met Leu Glu Leu Cys Gln Gly Leu Trp Gln Pro Val Ser Phe Gln Met 
            500                 505                 510         


Gln Ala Met Leu Leu Gly His Ser Thr Ala Gly Ala Ile Gly Arg Leu 
        515                 520                 525             


Leu Ala Ser Ser Pro Arg Ala Thr Val Thr Val Glu His Asn Pro Ala 
    530                 535                 540                 


Gly Gly Asp Tyr Ala Ser Val Arg Thr Ala Leu Leu Ala Ala Arg Ala 
545                 550                 555                 560 


Val Asp Arg Thr Arg Val Tyr Tyr Arg Leu Pro Gln Gly Tyr His Lys 
                565                 570                 575     


Asp Leu Leu Ala His Val Gly Arg Asn 
            580                 585 


<210>  6476
<211>  931
<212>  PRT
<213>  Homo sapiens

<400>  6476

Met Leu Leu Phe Phe Thr Leu Gly Leu Leu Ile His Phe Val Phe Phe 
1               5                   10                  15      


Ala Ser Ile Phe Asp Ile Tyr Phe Thr Ser Pro Leu Val His Gly Met 
            20                  25                  30          


Thr Pro Gln Phe Thr Pro Leu Pro Pro Pro Ala Arg Arg Leu Val Leu 
        35                  40                  45              


Phe Val Ala Asp Gly Leu Arg Ala Asp Ala Leu Tyr Glu Leu Asp Glu 
    50                  55                  60                  


Asn Gly Asn Ser Arg Ala Pro Phe Ile Arg Asn Ile Ile Met His Glu 
65                  70                  75                  80  


Gly Ser Trp Gly Ile Ser His Thr Arg Val Pro Thr Glu Ser Arg Pro 
                85                  90                  95      


Gly His Val Ala Leu Ile Ala Gly Phe Tyr Glu Asp Val Ser Ala Val 
            100                 105                 110         


Ala Lys Gly Trp Lys Glu Asn Pro Val Glu Phe Asp Ser Leu Phe Asn 
        115                 120                 125             


Glu Ser Lys Tyr Thr Trp Ser Trp Gly Ser Pro Asp Ile Leu Pro Met 
    130                 135                 140                 


Phe Ala Lys Gly Ala Ser Gly Asp His Val Tyr Thr Tyr Ser Tyr Asp 
145                 150                 155                 160 


Ala Lys Arg Glu Asp Phe Gly Ala Gln Asp Ala Thr Lys Leu Asp Thr 
                165                 170                 175     


Trp Val Phe Asp Asn Val Lys Asp Phe Phe His His Ala Arg Asn Asn 
            180                 185                 190         


Gln Ser Leu Phe Ser Lys Ile Asn Glu Glu Lys Ile Val Phe Phe Leu 
        195                 200                 205             


His Leu Leu Gly Ile Asp Thr Asn Gly His Ala His Arg Pro Ser Ser 
    210                 215                 220                 


Arg Asp Tyr Lys His Asn Ile Lys Lys Val Asp Asp Gly Val Lys Glu 
225                 230                 235                 240 


Ile Val Ser Met Phe Asn His Phe Tyr Gly Asn Asp Gly Lys Thr Thr 
                245                 250                 255     


Phe Ile Phe Thr Ser Asp His Gly Met Thr Asp Trp Gly Ser His Gly 
            260                 265                 270         


Ala Gly His Pro Ser Glu Thr Leu Thr Pro Leu Val Thr Trp Gly Ala 
        275                 280                 285             


Gly Ile Lys Tyr Pro Gln Arg Val Ser Ala Gln Gln Phe Asp Asp Ala 
    290                 295                 300                 


Phe Leu Lys Glu Trp Arg Leu Glu Asn Trp Lys Arg Leu Asp Val Asn 
305                 310                 315                 320 


Gln Ala Asp Ile Ala Pro Leu Met Thr Ser Leu Ile Gly Val Pro Phe 
                325                 330                 335     


Pro Leu Asn Ser Val Gly Ile Leu Pro Val Asp Tyr Leu Asn Asn Thr 
            340                 345                 350         


Asp Leu Phe Lys Ala Glu Ser Met Phe Thr Asn Ala Val Gln Ile Leu 
        355                 360                 365             


Glu Gln Phe Lys Val Lys Met Thr Gln Lys Lys Glu Val Thr Leu Pro 
    370                 375                 380                 


Phe Leu Phe Thr Pro Phe Lys Leu Leu Ser Asp Ser Lys Gln Phe Asn 
385                 390                 395                 400 


Ile Leu Arg Lys Ala Arg Ser Tyr Ile Lys His Arg Lys Phe Asp Glu 
                405                 410                 415     


Val Val Ser Leu Cys Lys Glu Leu Ile His Leu Ala Leu Lys Gly Leu 
            420                 425                 430         


Ser Tyr Tyr His Thr Tyr Asp Arg Phe Phe Leu Gly Val Asn Val Val 
        435                 440                 445             


Ile Gly Phe Val Gly Trp Ile Ser Tyr Ala Ser Leu Leu Ile Ile Lys 
    450                 455                 460                 


Ser His Ser Asn Leu Ile Lys Gly Val Ser Lys Glu Val Lys Lys Pro 
465                 470                 475                 480 


Ser His Leu Leu Pro Cys Ser Phe Val Ala Ile Gly Ile Leu Val Ala 
                485                 490                 495     


Phe Phe Leu Leu Ile Gln Ala Cys Pro Trp Thr Tyr Tyr Val Tyr Gly 
            500                 505                 510         


Leu Leu Pro Leu Pro Ile Trp Tyr Ala Val Leu Arg Glu Phe Gln Val 
        515                 520                 525             


Ile Gln Asp Leu Val Val Ser Val Leu Thr Tyr Pro Leu Ser His Phe 
    530                 535                 540                 


Val Gly Tyr Leu Leu Ala Phe Thr Leu Gly Ile Glu Val Leu Val Leu 
545                 550                 555                 560 


Ser Phe Phe Tyr Arg Tyr Met Leu Thr Ala Gly Leu Thr Ala Phe Ala 
                565                 570                 575     


Ala Trp Pro Phe Leu Thr Arg Leu Trp Thr Arg Ala Lys Met Thr Ser 
            580                 585                 590         


Leu Ser Trp Thr Phe Phe Ser Leu Leu Leu Ala Val Phe Pro Leu Met 
        595                 600                 605             


Pro Val Val Gly Arg Lys Pro Asp Ile Ser Leu Val Met Gly Ala Gly 
    610                 615                 620                 


Leu Leu Val Leu Leu Leu Ser Leu Cys Val Val Thr Ser Leu Met Lys 
625                 630                 635                 640 


Arg Lys Asp Ser Phe Ile Lys Glu Glu Leu Leu Val His Leu Leu Gln 
                645                 650                 655     


Val Leu Ser Thr Val Leu Ser Met Tyr Val Val Tyr Ser Thr Gln Ser 
            660                 665                 670         


Ser Leu Leu Arg Lys Gln Gly Leu Pro Leu Met Asn Gln Ile Ile Ser 
        675                 680                 685             


Trp Ala Thr Leu Ala Ser Ser Leu Val Val Pro Leu Leu Ser Ser Pro 
    690                 695                 700                 


Val Leu Phe Gln Arg Leu Phe Ser Ile Leu Leu Ser Leu Met Ser Thr 
705                 710                 715                 720 


Tyr Leu Leu Leu Ser Thr Gly Tyr Glu Ala Leu Phe Pro Leu Val Leu 
                725                 730                 735     


Ser Cys Leu Met Phe Val Trp Ile Asn Ile Glu Gln Glu Thr Leu Gln 
            740                 745                 750         


Gln Ser Gly Val Cys Cys Lys Gln Lys Leu Thr Ser Ile Gln Phe Ser 
        755                 760                 765             


Tyr Asn Thr Asp Ile Thr Gln Phe Arg Gln Leu Tyr Leu Asp Asp Ile 
    770                 775                 780                 


Arg Arg Ala Phe Phe Leu Val Phe Phe Leu Val Thr Ala Phe Phe Gly 
785                 790                 795                 800 


Thr Gly Asn Ile Ala Ser Ile Asn Ser Phe Asp Leu Ala Ser Val Tyr 
                805                 810                 815     


Cys Phe Leu Thr Val Phe Ser Pro Phe Met Met Gly Ala Leu Met Met 
            820                 825                 830         


Trp Lys Ile Leu Ile Pro Phe Val Leu Val Met Cys Ala Phe Glu Ala 
        835                 840                 845             


Val Gln Leu Thr Thr Gln Leu Ser Ser Lys Ser Leu Phe Leu Ile Val 
    850                 855                 860                 


Leu Val Ile Ser Asp Ile Met Ala Leu His Phe Phe Phe Leu Val Lys 
865                 870                 875                 880 


Asp Tyr Gly Ser Trp Leu Asp Ile Gly Thr Ser Ile Ser His Tyr Val 
                885                 890                 895     


Ile Val Met Ser Met Thr Ile Phe Leu Val Phe Leu Asn Gly Leu Ala 
            900                 905                 910         


Gln Leu Leu Thr Thr Lys Lys Leu Arg Leu Cys Gly Lys Pro Lys Ser 
        915                 920                 925             


His Phe Met 
    930     


<210>  6477
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  6477

Met Glu Trp Asp Asn Gly Thr Gly Gln Ala Leu Gly Leu Pro Pro Thr 
1               5                   10                  15      


Thr Cys Val Tyr Arg Glu Asn Phe Lys Gln Leu Leu Leu Pro Pro Val 
            20                  25                  30          


Tyr Ser Ala Val Leu Ala Ala Gly Leu Pro Leu Asn Ile Cys Val Ile 
        35                  40                  45              


Thr Gln Ile Cys Thr Ser Arg Arg Ala Leu Thr Arg Thr Ala Val Tyr 
    50                  55                  60                  


Thr Leu Asn Leu Ala Leu Ala Asp Leu Leu Tyr Ala Cys Ser Leu Pro 
65                  70                  75                  80  


Leu Leu Ile Tyr Asn Tyr Ala Gln Gly Asp His Trp Pro Phe Gly Asp 
                85                  90                  95      


Phe Ala Cys Arg Leu Val Arg Phe Leu Phe Tyr Ala Asn Leu His Gly 
            100                 105                 110         


Ser Ile Leu Phe Leu Thr Cys Ile Ser Phe Gln Arg Tyr Leu Gly Ile 
        115                 120                 125             


Cys His Pro Leu Ala Pro Trp His Lys Arg Gly Gly Arg Arg Ala Ala 
    130                 135                 140                 


Trp Leu Val Cys Val Ala Val Trp Leu Ala Val Thr Thr Gln Cys Leu 
145                 150                 155                 160 


Pro Thr Ala Ile Phe Ala Ala Thr Gly Ile Gln Arg Asn Arg Thr Val 
                165                 170                 175     


Cys Tyr Asp Leu Ser Pro Pro Ala Leu Ala Thr His Tyr Met Pro Tyr 
            180                 185                 190         


Gly Met Ala Leu Thr Val Ile Gly Phe Leu Leu Pro Phe Ala Ala Leu 
        195                 200                 205             


Leu Ala Cys Tyr Cys Leu Leu Ala Cys Arg Leu Cys Arg Gln Asp Gly 
    210                 215                 220                 


Pro Ala Glu Pro Val Ala Gln Glu Arg Arg Gly Lys Ala Ala Arg Met 
225                 230                 235                 240 


Ala Val Val Val Ala Ala Ala Phe Ala Ile Ser Phe Leu Pro Phe His 
                245                 250                 255     


Ile Thr Lys Thr Ala Tyr Leu Ala Val Arg Ser Thr Pro Gly Val Pro 
            260                 265                 270         


Cys Thr Val Leu Glu Ala Phe Ala Ala Ala Tyr Lys Gly Thr Arg Pro 
        275                 280                 285             


Phe Ala Ser Ala Asn Ser Val Leu Asp Pro Ile Leu Phe Tyr Phe Thr 
    290                 295                 300                 


Gln Lys Lys Phe Arg Arg Arg Pro His Glu Leu Leu Gln Lys Leu Thr 
305                 310                 315                 320 


Ala Lys Trp Gln Arg Gln Gly Arg 
                325             


<210>  6478
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  6478

Met Glu Trp Asp Asn Gly Thr Gly Gln Ala Leu Gly Leu Pro Pro Thr 
1               5                   10                  15      


Thr Cys Val Tyr Arg Glu Asn Phe Lys Gln Leu Leu Leu Pro Pro Val 
            20                  25                  30          


Tyr Ser Ala Val Leu Ala Ala Gly Leu Pro Leu Asn Ile Cys Val Ile 
        35                  40                  45              


Thr Gln Ile Cys Thr Ser Arg Arg Ala Leu Thr Arg Thr Ala Val Tyr 
    50                  55                  60                  


Thr Leu Asn Leu Ala Leu Ala Asp Leu Leu Tyr Ala Cys Ser Leu Pro 
65                  70                  75                  80  


Leu Leu Ile Tyr Asn Tyr Ala Gln Gly Asp His Trp Pro Phe Gly Asp 
                85                  90                  95      


Phe Ala Cys Arg Leu Val Arg Phe Leu Phe Tyr Ala Asn Leu His Gly 
            100                 105                 110         


Ser Ile Leu Phe Leu Thr Cys Ile Ser Phe Gln Arg Tyr Leu Gly Ile 
        115                 120                 125             


Cys His Pro Leu Ala Pro Trp His Lys Arg Gly Gly Arg Arg Ala Ala 
    130                 135                 140                 


Trp Leu Val Cys Val Ala Val Trp Leu Ala Val Thr Thr Gln Cys Leu 
145                 150                 155                 160 


Pro Thr Ala Ile Phe Ala Ala Thr Gly Ile Gln Arg Asn Arg Thr Val 
                165                 170                 175     


Cys Tyr Asp Leu Ser Pro Pro Ala Leu Ala Thr His Tyr Met Pro Tyr 
            180                 185                 190         


Gly Met Ala Leu Thr Val Ile Gly Phe Leu Leu Pro Phe Ala Ala Leu 
        195                 200                 205             


Leu Ala Cys Tyr Cys Leu Leu Ala Cys Arg Leu Cys Arg Gln Asp Gly 
    210                 215                 220                 


Pro Ala Glu Pro Val Ala Gln Glu Arg Arg Gly Lys Ala Ala Arg Met 
225                 230                 235                 240 


Ala Val Val Val Ala Ala Ala Phe Ala Ile Ser Phe Leu Pro Phe His 
                245                 250                 255     


Ile Thr Lys Thr Ala Tyr Leu Ala Val Arg Ser Thr Pro Gly Val Pro 
            260                 265                 270         


Cys Thr Val Leu Glu Ala Phe Ala Ala Ala Tyr Lys Gly Thr Arg Pro 
        275                 280                 285             


Phe Ala Ser Ala Asn Ser Val Leu Asp Pro Ile Leu Phe Tyr Phe Thr 
    290                 295                 300                 


Gln Lys Lys Phe Arg Arg Arg Pro His Glu Leu Leu Gln Lys Leu Thr 
305                 310                 315                 320 


Ala Lys Trp Gln Arg Gln Gly Arg 
                325             


<210>  6479
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  6479

Met Glu Trp Asp Asn Gly Thr Gly Gln Ala Leu Gly Leu Pro Pro Thr 
1               5                   10                  15      


Thr Cys Val Tyr Arg Glu Asn Phe Lys Gln Leu Leu Leu Pro Pro Val 
            20                  25                  30          


Tyr Ser Ala Val Leu Ala Ala Gly Leu Pro Leu Asn Ile Cys Val Ile 
        35                  40                  45              


Thr Gln Ile Cys Thr Ser Arg Arg Ala Leu Thr Arg Thr Ala Val Tyr 
    50                  55                  60                  


Thr Leu Asn Leu Ala Leu Ala Asp Leu Leu Tyr Ala Cys Ser Leu Pro 
65                  70                  75                  80  


Leu Leu Ile Tyr Asn Tyr Ala Gln Gly Asp His Trp Pro Phe Gly Asp 
                85                  90                  95      


Phe Ala Cys Arg Leu Val Arg Phe Leu Phe Tyr Ala Asn Leu His Gly 
            100                 105                 110         


Ser Ile Leu Phe Leu Thr Cys Ile Ser Phe Gln Arg Tyr Leu Gly Ile 
        115                 120                 125             


Cys His Pro Leu Ala Pro Trp His Lys Arg Gly Gly Arg Arg Ala Ala 
    130                 135                 140                 


Trp Leu Val Cys Val Ala Val Trp Leu Ala Val Thr Thr Gln Cys Leu 
145                 150                 155                 160 


Pro Thr Ala Ile Phe Ala Ala Thr Gly Ile Gln Arg Asn Arg Thr Val 
                165                 170                 175     


Cys Tyr Asp Leu Ser Pro Pro Ala Leu Ala Thr His Tyr Met Pro Tyr 
            180                 185                 190         


Gly Met Ala Leu Thr Val Ile Gly Phe Leu Leu Pro Phe Ala Ala Leu 
        195                 200                 205             


Leu Ala Cys Tyr Cys Leu Leu Ala Cys Arg Leu Cys Arg Gln Asp Gly 
    210                 215                 220                 


Pro Ala Glu Pro Val Ala Gln Glu Arg Arg Gly Lys Ala Ala Arg Met 
225                 230                 235                 240 


Ala Val Val Val Ala Ala Ala Phe Ala Ile Ser Phe Leu Pro Phe His 
                245                 250                 255     


Ile Thr Lys Thr Ala Tyr Leu Ala Val Arg Ser Thr Pro Gly Val Pro 
            260                 265                 270         


Cys Thr Val Leu Glu Ala Phe Ala Ala Ala Tyr Lys Gly Thr Arg Pro 
        275                 280                 285             


Phe Ala Ser Ala Asn Ser Val Leu Asp Pro Ile Leu Phe Tyr Phe Thr 
    290                 295                 300                 


Gln Lys Lys Phe Arg Arg Arg Pro His Glu Leu Leu Gln Lys Leu Thr 
305                 310                 315                 320 


Ala Lys Trp Gln Arg Gln Gly Arg 
                325             


<210>  6480
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  6480

Met Leu Thr Leu Thr Arg Ile Arg Thr Val Ser Tyr Glu Val Arg Ser 
1               5                   10                  15      


Thr Phe Leu Phe Ile Ser Val Leu Glu Phe Ala Val Gly Phe Leu Thr 
            20                  25                  30          


Asn Ala Phe Val Phe Leu Val Asn Phe Trp Asp Val Val Lys Arg Gln 
        35                  40                  45              


Ala Leu Ser Asn Ser Asp Cys Val Leu Leu Cys Leu Ser Ile Ser Arg 
    50                  55                  60                  


Leu Phe Leu His Gly Leu Leu Phe Leu Ser Ala Ile Gln Leu Thr His 
65                  70                  75                  80  


Phe Gln Lys Leu Ser Glu Pro Leu Asn His Ser Tyr Gln Ala Ile Ile 
                85                  90                  95      


Met Leu Trp Met Ile Ala Asn Gln Ala Asn Leu Trp Leu Ala Ala Cys 
            100                 105                 110         


Leu Ser Leu Leu Tyr Cys Ser Lys Leu Ile Arg Phe Ser His Thr Phe 
        115                 120                 125             


Leu Ile Cys Leu Ala Ser Trp Val Ser Arg Lys Ile Ser Gln Met Leu 
    130                 135                 140                 


Leu Gly Ile Ile Leu Cys Ser Cys Ile Cys Thr Val Leu Cys Val Trp 
145                 150                 155                 160 


Cys Phe Phe Ser Arg Pro His Phe Thr Val Thr Thr Val Leu Phe Met 
                165                 170                 175     


Asn Asn Asn Thr Arg Leu Asn Trp Gln Ile Lys Asp Leu Asn Leu Phe 
            180                 185                 190         


Tyr Ser Phe Leu Phe Cys Tyr Leu Trp Ser Val Pro Pro Phe Leu Leu 
        195                 200                 205             


Phe Leu Val Ser Ser Gly Met Leu Thr Val Ser Leu Gly Arg His Met 
    210                 215                 220                 


Arg Thr Met Lys Val Tyr Thr Arg Asn Ser Arg Asp Pro Ser Leu Glu 
225                 230                 235                 240 


Ala His Ile Lys Ala Leu Lys Ser Leu Val Ser Phe Phe Cys Phe Phe 
                245                 250                 255     


Val Ile Ser Ser Cys Val Ala Phe Ile Ser Val Pro Leu Leu Ile Leu 
            260                 265                 270         


Trp Arg Asp Lys Ile Gly Val Met Val Cys Val Gly Ile Met Ala Ala 
        275                 280                 285             


Cys Pro Ser Gly His Ala Ala Ile Leu Ile Ser Gly Asn Ala Lys Leu 
    290                 295                 300                 


Arg Arg Ala Val Met Thr Ile Leu Leu Trp Ala Gln Ser Ser Leu Lys 
305                 310                 315                 320 


Val Arg Ala Asp His Lys Ala Asp Ser Arg Thr Leu Cys 
                325                 330             


<210>  6481
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  6481

Met Glu Leu Leu Lys Leu Asn Arg Ser Val Gln Gly Thr Gly Pro Gly 
1               5                   10                  15      


Pro Gly Ala Ser Leu Cys Arg Pro Gly Ala Pro Leu Leu Asn Ser Ser 
            20                  25                  30          


Ser Val Gly Asn Leu Ser Cys Glu Pro Pro Arg Ile Arg Gly Ala Gly 
        35                  40                  45              


Thr Arg Glu Leu Glu Leu Ala Ile Arg Ile Thr Leu Tyr Ala Val Ile 
    50                  55                  60                  


Phe Leu Met Ser Val Gly Gly Asn Met Leu Ile Ile Val Val Leu Gly 
65                  70                  75                  80  


Leu Ser Arg Arg Leu Arg Thr Val Thr Asn Ala Phe Leu Leu Ser Leu 
                85                  90                  95      


Ala Val Ser Asp Leu Leu Leu Ala Val Ala Cys Met Pro Phe Thr Leu 
            100                 105                 110         


Leu Pro Asn Leu Met Gly Thr Phe Ile Phe Gly Thr Val Ile Cys Lys 
        115                 120                 125             


Ala Val Ser Tyr Leu Met Gly Val Ser Val Ser Val Ser Thr Leu Ser 
    130                 135                 140                 


Leu Val Ala Ile Ala Leu Glu Arg Tyr Ser Ala Ile Cys Arg Pro Leu 
145                 150                 155                 160 


Gln Ala Arg Val Trp Gln Thr Arg Ser His Ala Ala Arg Val Ile Val 
                165                 170                 175     


Ala Thr Trp Leu Leu Ser Gly Leu Leu Met Val Pro Tyr Pro Val Tyr 
            180                 185                 190         


Thr Val Val Gln Pro Val Gly Pro Arg Val Leu Gln Cys Val His Arg 
        195                 200                 205             


Trp Pro Ser Ala Arg Val Arg Gln Thr Trp Ser Val Leu Leu Leu Leu 
    210                 215                 220                 


Leu Leu Phe Phe Ile Pro Gly Val Val Met Ala Val Ala Tyr Gly Leu 
225                 230                 235                 240 


Ile Ser Arg Glu Leu Tyr Leu Gly Leu Arg Phe Asp Gly Asp Ser Asp 
                245                 250                 255     


Ser Asp Ser Gln Ser Arg Val Arg Asn Gln Gly Gly Leu Pro Gly Ala 
            260                 265                 270         


Val His Gln Asn Gly Arg Cys Arg Pro Glu Thr Gly Ala Val Gly Glu 
        275                 280                 285             


Asp Ser Asp Gly Cys Tyr Val Gln Leu Pro Arg Ser Arg Pro Ala Leu 
    290                 295                 300                 


Glu Leu Thr Ala Leu Thr Ala Pro Gly Pro Gly Ser Gly Ser Arg Pro 
305                 310                 315                 320 


Thr Gln Ala Lys Leu Leu Ala Lys Lys Arg Val Val Arg Met Leu Leu 
                325                 330                 335     


Val Ile Val Val Leu Phe Phe Leu Cys Trp Leu Pro Val Tyr Ser Ala 
            340                 345                 350         


Asn Thr Trp Arg Ala Phe Asp Gly Pro Gly Ala His Arg Ala Leu Ser 
        355                 360                 365             


Gly Ala Pro Ile Ser Phe Ile His Leu Leu Ser Tyr Ala Ser Ala Cys 
    370                 375                 380                 


Val Asn Pro Leu Val Tyr Cys Phe Met His Arg Arg Phe Arg Gln Ala 
385                 390                 395                 400 


Cys Leu Glu Thr Cys Ala Arg Cys Cys Pro Arg Pro Pro Arg Ala Arg 
                405                 410                 415     


Pro Arg Ala Leu Pro Asp Glu Asp Pro Pro Thr Pro Ser Ile Ala Ser 
            420                 425                 430         


Leu Ser Arg Leu Ser Tyr Thr Thr Ile Ser Thr Leu Gly Pro Gly 
        435                 440                 445         


<210>  6482
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  6482

Met Gln Ala Val Asp Asn Leu Thr Ser Ala Pro Gly Asn Thr Ser Leu 
1               5                   10                  15      


Cys Thr Arg Asp Tyr Lys Ile Thr Gln Val Leu Phe Pro Leu Leu Tyr 
            20                  25                  30          


Thr Val Leu Phe Phe Val Gly Leu Ile Thr Asn Gly Leu Ala Met Arg 
        35                  40                  45              


Ile Phe Phe Gln Ile Arg Ser Lys Ser Asn Phe Ile Ile Phe Leu Lys 
    50                  55                  60                  


Asn Thr Val Ile Ser Asp Leu Leu Met Ile Leu Thr Phe Pro Phe Lys 
65                  70                  75                  80  


Ile Leu Ser Asp Ala Lys Leu Gly Thr Gly Pro Leu Arg Thr Phe Val 
                85                  90                  95      


Cys Gln Val Thr Ser Val Ile Phe Tyr Phe Thr Met Tyr Ile Ser Ile 
            100                 105                 110         


Ser Phe Leu Gly Leu Ile Thr Ile Asp Arg Tyr Gln Lys Thr Thr Arg 
        115                 120                 125             


Pro Phe Lys Thr Ser Asn Pro Lys Asn Leu Leu Gly Ala Lys Ile Leu 
    130                 135                 140                 


Ser Val Val Ile Trp Ala Phe Met Phe Leu Leu Ser Leu Pro Asn Met 
145                 150                 155                 160 


Ile Leu Thr Asn Arg Gln Pro Arg Asp Lys Asn Val Lys Lys Cys Ser 
                165                 170                 175     


Phe Leu Lys Ser Glu Phe Gly Leu Val Trp His Glu Ile Val Asn Tyr 
            180                 185                 190         


Ile Cys Gln Val Ile Phe Trp Ile Asn Phe Leu Ile Val Ile Val Cys 
        195                 200                 205             


Tyr Thr Leu Ile Thr Lys Glu Leu Tyr Arg Ser Tyr Val Arg Thr Arg 
    210                 215                 220                 


Gly Val Gly Lys Val Pro Arg Lys Lys Val Asn Val Lys Val Phe Ile 
225                 230                 235                 240 


Ile Ile Ala Val Phe Phe Ile Cys Phe Val Pro Phe His Phe Ala Arg 
                245                 250                 255     


Ile Pro Tyr Thr Leu Ser Gln Thr Arg Asp Val Phe Asp Cys Thr Ala 
            260                 265                 270         


Glu Asn Thr Leu Phe Tyr Val Lys Glu Ser Thr Leu Trp Leu Thr Ser 
        275                 280                 285             


Leu Asn Ala Cys Leu Asp Pro Phe Ile Tyr Phe Phe Leu Cys Lys Ser 
    290                 295                 300                 


Phe Arg Asn Ser Leu Ile Ser Met Leu Lys Cys Pro Asn Ser Ala Thr 
305                 310                 315                 320 


Ser Leu Ser Gln Asp Asn Arg Lys Lys Glu Gln Asp Gly Gly Asp Pro 
                325                 330                 335     


Asn Glu Glu Thr Pro Met 
            340         


<210>  6483
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  6483

Met Leu Gly Arg Cys Phe Pro Pro Asp Thr Lys Glu Lys Gln Gln Leu 
1               5                   10                  15      


Arg Met Thr Lys Leu Cys Asp Pro Ala Glu Ser Glu Leu Ser Pro Phe 
            20                  25                  30          


Leu Ile Thr Leu Ile Leu Ala Val Leu Leu Ala Glu Tyr Leu Ile Gly 
        35                  40                  45              


Ile Ile Ala Asn Gly Phe Ile Met Ala Ile His Ala Ala Glu Trp Val 
    50                  55                  60                  


Gln Asn Lys Ala Val Ser Thr Ser Gly Arg Ile Leu Val Phe Leu Ser 
65                  70                  75                  80  


Val Ser Arg Ile Ala Leu Gln Ser Leu Met Met Leu Glu Ile Thr Ile 
                85                  90                  95      


Ser Ser Thr Ser Leu Ser Phe Tyr Ser Glu Asp Ala Val Tyr Tyr Ala 
            100                 105                 110         


Phe Lys Ile Ser Phe Ile Phe Leu Asn Phe Cys Ser Leu Trp Phe Ala 
        115                 120                 125             


Ala Trp Leu Ser Phe Phe Tyr Phe Val Lys Ile Ala Asn Phe Ser Tyr 
    130                 135                 140                 


Pro Leu Phe Leu Lys Leu Arg Trp Arg Ile Thr Gly Leu Ile Pro Trp 
145                 150                 155                 160 


Leu Leu Trp Leu Ser Val Phe Ile Ser Phe Ser His Ser Met Phe Cys 
                165                 170                 175     


Ile Asn Ile Cys Thr Val Tyr Cys Asn Asn Ser Phe Pro Ile His Ser 
            180                 185                 190         


Ser Asn Ser Thr Lys Lys Thr Tyr Leu Ser Glu Ile Asn Val Val Gly 
        195                 200                 205             


Leu Ala Phe Phe Phe Asn Leu Gly Ile Val Thr Pro Leu Ile Met Phe 
    210                 215                 220                 


Ile Leu Thr Ala Thr Leu Leu Ile Leu Ser Leu Lys Arg His Thr Leu 
225                 230                 235                 240 


His Met Gly Ser Asn Ala Thr Gly Ser Asn Asp Pro Ser Met Glu Ala 
                245                 250                 255     


His Met Gly Ala Ile Lys Ala Ile Ser Tyr Phe Leu Ile Leu Tyr Ile 
            260                 265                 270         


Phe Asn Ala Val Ala Leu Phe Ile Tyr Leu Ser Asn Met Phe Asp Ile 
        275                 280                 285             


Asn Ser Leu Trp Asn Asn Leu Cys Gln Ile Ile Met Ala Ala Tyr Pro 
    290                 295                 300                 


Ala Ser His Ser Ile Leu Leu Ile Gln Asp Asn Pro Gly Leu Arg Arg 
305                 310                 315                 320 


Ala Trp Lys Arg Leu Gln Leu Arg Leu His Leu Tyr Pro Lys Glu Trp 
                325                 330                 335     


Thr Leu 
        


<210>  6484
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  6484

Met Ala Thr Val Asn Thr Asp Ala Thr Asp Lys Asp Ile Ser Lys Phe 
1               5                   10                  15      


Lys Val Thr Phe Thr Leu Val Val Ser Gly Ile Glu Cys Ile Thr Gly 
            20                  25                  30          


Ile Leu Gly Ser Gly Phe Ile Thr Ala Ile Tyr Gly Ala Glu Trp Ala 
        35                  40                  45              


Arg Gly Lys Thr Leu Pro Thr Gly Asp Arg Ile Met Leu Met Leu Ser 
    50                  55                  60                  


Phe Ser Arg Leu Leu Leu Gln Ile Trp Met Met Leu Glu Asn Ile Phe 
65                  70                  75                  80  


Ser Leu Leu Phe Arg Ile Val Tyr Asn Gln Asn Ser Val Tyr Ile Leu 
                85                  90                  95      


Phe Lys Val Ile Thr Val Phe Leu Asn His Ser Asn Leu Trp Phe Ala 
            100                 105                 110         


Ala Trp Leu Lys Val Phe Tyr Cys Leu Arg Ile Ala Asn Phe Asn His 
        115                 120                 125             


Pro Leu Phe Phe Leu Met Lys Arg Lys Ile Ile Val Leu Met Pro Trp 
    130                 135                 140                 


Leu Leu Arg Leu Ser Val Leu Val Ser Leu Ser Phe Ser Phe Pro Leu 
145                 150                 155                 160 


Ser Arg Asp Val Phe Asn Val Tyr Val Asn Ser Ser Ile Pro Ile Pro 
                165                 170                 175     


Ser Ser Asn Ser Thr Glu Lys Lys Tyr Phe Ser Glu Thr Asn Met Val 
            180                 185                 190         


Asn Leu Val Phe Phe Tyr Asn Met Gly Ile Phe Val Pro Leu Ile Met 
        195                 200                 205             


Phe Ile Leu Ala Ala Thr Leu Leu Ile Leu Ser Leu Lys Arg His Thr 
    210                 215                 220                 


Leu His Met Gly Ser Asn Ala Thr Gly Ser Arg Asp Pro Ser Met Lys 
225                 230                 235                 240 


Ala His Ile Gly Ala Ile Lys Ala Thr Ser Tyr Phe Leu Ile Leu Tyr 
                245                 250                 255     


Ile Phe Asn Ala Ile Ala Leu Phe Leu Ser Thr Ser Asn Ile Phe Asp 
            260                 265                 270         


Thr Tyr Ser Ser Trp Asn Ile Leu Cys Lys Ile Ile Met Ala Ala Tyr 
        275                 280                 285             


Pro Ala Gly His Ser Val Gln Leu Ile Leu Gly Asn Pro Gly Leu Arg 
    290                 295                 300                 


Arg Ala Trp Lys Arg Phe Gln His Gln Val Pro Leu Tyr Leu Lys Gly 
305                 310                 315                 320 


Gln Thr Leu 
            


<210>  6485
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  6485

Met Gln Ala Ala Leu Thr Ala Phe Phe Val Leu Leu Phe Ser Leu Leu 
1               5                   10                  15      


Ser Leu Leu Gly Ile Ala Ala Asn Gly Phe Ile Val Leu Val Leu Gly 
            20                  25                  30          


Arg Glu Trp Leu Arg Tyr Gly Arg Leu Leu Pro Leu Asp Met Ile Leu 
        35                  40                  45              


Ile Ser Leu Gly Ala Ser Arg Phe Cys Leu Gln Leu Val Gly Thr Val 
    50                  55                  60                  


His Asn Phe Tyr Tyr Ser Ala Gln Lys Val Glu Tyr Ser Gly Gly Leu 
65                  70                  75                  80  


Gly Arg Gln Phe Phe His Leu His Trp His Phe Leu Asn Ser Ala Thr 
                85                  90                  95      


Phe Trp Phe Cys Ser Trp Leu Ser Val Leu Phe Cys Val Lys Ile Ala 
            100                 105                 110         


Asn Ile Thr His Ser Thr Phe Leu Trp Leu Lys Trp Arg Phe Pro Gly 
        115                 120                 125             


Trp Val Pro Trp Leu Leu Leu Gly Ser Val Leu Ile Ser Phe Ile Ile 
    130                 135                 140                 


Thr Leu Leu Phe Phe Trp Val Asn Tyr Pro Val Tyr Gln Glu Phe Leu 
145                 150                 155                 160 


Ile Arg Lys Phe Ser Gly Asn Met Thr Tyr Lys Trp Asn Thr Arg Ile 
                165                 170                 175     


Glu Thr Tyr Tyr Phe Pro Ser Leu Lys Leu Val Ile Trp Ser Ile Pro 
            180                 185                 190         


Phe Ser Val Phe Leu Val Ser Ile Met Leu Leu Ile Asn Ser Leu Arg 
        195                 200                 205             


Arg His Thr Gln Arg Met Gln His Asn Gly His Ser Leu Gln Asp Pro 
    210                 215                 220                 


Ser Thr Gln Ala His Thr Arg Ala Leu Lys Ser Leu Ile Ser Phe Leu 
225                 230                 235                 240 


Ile Leu Tyr Ala Leu Ser Phe Leu Ser Leu Ile Ile Asp Ala Ala Lys 
                245                 250                 255     


Phe Ile Ser Met Gln Asn Asp Phe Tyr Trp Pro Trp Gln Ile Ala Val 
            260                 265                 270         


Tyr Leu Cys Ile Ser Val His Pro Phe Ile Leu Ile Phe Ser Asn Leu 
        275                 280                 285             


Lys Leu Arg Ser Val Phe Ser Gln Leu Leu Leu Leu Ala Arg Gly Phe 
    290                 295                 300                 


Trp Val Ala 
305         


<210>  6486
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  6486

Met Ile Thr Phe Leu Tyr Ile Phe Phe Ser Ile Leu Ile Met Val Leu 
1               5                   10                  15      


Phe Val Leu Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Phe 
            20                  25                  30          


Ile Asp Trp Val Lys Arg Lys Lys Ile Ser Ser Ala Asp Gln Ile Leu 
        35                  40                  45              


Thr Ala Leu Ala Val Ser Arg Ile Gly Leu Leu Trp Ala Leu Leu Leu 
    50                  55                  60                  


Asn Trp Tyr Leu Thr Val Leu Asn Pro Ala Phe Tyr Ser Val Glu Leu 
65                  70                  75                  80  


Arg Ile Thr Ser Tyr Asn Ala Trp Val Val Thr Asn His Phe Ser Met 
                85                  90                  95      


Trp Leu Ala Ala Asn Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn 
            100                 105                 110         


Phe Ser Asn Leu Leu Phe Leu His Leu Lys Arg Arg Val Arg Ser Val 
        115                 120                 125             


Ile Leu Val Ile Leu Leu Gly Thr Leu Ile Phe Leu Val Cys His Leu 
    130                 135                 140                 


Leu Val Ala Asn Met Asp Glu Ser Met Trp Ala Glu Glu Tyr Glu Gly 
145                 150                 155                 160 


Asn Met Thr Gly Lys Met Lys Leu Arg Asn Thr Val His Leu Ser Tyr 
                165                 170                 175     


Leu Thr Val Thr Thr Leu Trp Ser Phe Ile Pro Phe Thr Leu Ser Leu 
            180                 185                 190         


Ile Ser Phe Leu Met Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys 
        195                 200                 205             


Met Gln Leu His Gly Glu Gly Ser Gln Asp Leu Ser Thr Lys Val His 
    210                 215                 220                 


Ile Lys Ala Leu Gln Thr Leu Ile Ser Phe Leu Leu Leu Cys Ala Ile 
225                 230                 235                 240 


Phe Phe Leu Phe Leu Ile Val Ser Val Trp Ser Pro Arg Arg Leu Arg 
                245                 250                 255     


Asn Asp Pro Val Val Met Val Ser Lys Ala Val Gly Asn Ile Tyr Leu 
            260                 265                 270         


Ala Phe Asp Ser Phe Ile Leu Ile Trp Arg Thr Lys Lys Leu Lys His 
        275                 280                 285             


Thr Phe Leu Leu Ile Leu Cys Gln Ile Arg Cys 
    290                 295                 


<210>  6487
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  6487

Met Ile Ile Lys His Phe Phe Gly Thr Val Leu Val Leu Leu Ala Ser 
1               5                   10                  15      


Thr Thr Ile Phe Ser Leu Asp Leu Lys Leu Ile Ile Phe Gln Gln Arg 
            20                  25                  30          


Gln Val Asn Gln Glu Ser Leu Lys Leu Leu Asn Lys Leu Gln Thr Leu 
        35                  40                  45              


Ser Ile Gln Gln Cys Leu Pro His Arg Lys Asn Phe Leu Leu Pro Gln 
    50                  55                  60                  


Lys Ser Leu Ser Pro Gln Gln Tyr Gln Lys Gly His Thr Leu Ala Ile 
65                  70                  75                  80  


Leu His Glu Met Leu Gln Gln Ile Phe Ser Leu Phe Arg Ala Asn Ile 
                85                  90                  95      


Ser Leu Asp Gly Trp Glu Glu Asn His Thr Glu Lys Phe Leu Ile Gln 
            100                 105                 110         


Leu His Gln Gln Leu Glu Tyr Leu Glu Ala Leu Met Gly Leu Glu Ala 
        115                 120                 125             


Glu Lys Leu Ser Gly Thr Leu Gly Ser Asp Asn Leu Arg Leu Gln Val 
    130                 135                 140                 


Lys Met Tyr Phe Arg Arg Ile His Asp Tyr Leu Glu Asn Gln Asp Tyr 
145                 150                 155                 160 


Ser Thr Cys Ala Trp Ala Ile Val Gln Val Glu Ile Ser Arg Cys Leu 
                165                 170                 175     


Phe Phe Val Phe Ser Leu Thr Glu Lys Leu Ser Lys Gln Gly Arg Pro 
            180                 185                 190         


Leu Asn Asp Met Lys Gln Glu Leu Thr Thr Glu Phe Arg Ser Pro Arg 
        195                 200                 205             


<210>  6488
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  6488

Met Phe Asp Lys Thr Arg Leu Pro Tyr Val Ala Leu Asp Val Leu Cys 
1               5                   10                  15      


Val Leu Leu Ala Ser Met Pro Met Ala Val Leu Lys Leu Gly Gln Ile 
            20                  25                  30          


Tyr Pro Phe Gln Arg Gly Phe Phe Cys Lys Asp Asn Ser Ile Asn Tyr 
        35                  40                  45              


Pro Tyr His Asp Ser Thr Val Thr Ser Thr Val Leu Ile Leu Val Gly 
    50                  55                  60                  


Val Gly Leu Pro Ile Ser Ser Ile Ile Leu Gly Glu Thr Leu Ser Val 
65                  70                  75                  80  


Tyr Cys Asn Leu Leu His Ser Asn Ser Phe Ile Arg Asn Asn Tyr Ile 
                85                  90                  95      


Ala Thr Ile Tyr Lys Ala Ile Gly Thr Phe Leu Phe Gly Ala Ala Ala 
            100                 105                 110         


Ser Gln Ser Leu Thr Asp Ile Ala Lys Tyr Ser Ile Gly Arg Leu Arg 
        115                 120                 125             


Pro His Phe Leu Asp Val Cys Asp Pro Asp Trp Ser Lys Ile Asn Cys 
    130                 135                 140                 


Ser Asp Gly Tyr Ile Glu Tyr Tyr Ile Cys Arg Gly Asn Ala Glu Arg 
145                 150                 155                 160 


Val Lys Glu Gly Arg Leu Ser Phe Tyr Ser Gly His Ser Ser Phe Ser 
                165                 170                 175     


Met Tyr Cys Met Leu Phe Val Ala Leu Tyr Leu Gln Ala Arg Met Lys 
            180                 185                 190         


Gly Asp Trp Ala Arg Leu Leu Arg Pro Thr Leu Gln Phe Gly Leu Val 
        195                 200                 205             


Ala Val Ser Ile Tyr Val Gly Leu Ser Arg Val Ser Asp Tyr Lys His 
    210                 215                 220                 


His Trp Ser Asp Val Leu Thr Gly Leu Ile Gln Gly Ala Leu Val Ala 
225                 230                 235                 240 


Ile Leu Val Ala Val Tyr Val Ser Asp Phe Phe Lys Glu Arg Thr Ser 
                245                 250                 255     


Phe Lys Glu Arg Lys Glu Glu Asp Ser His Thr Thr Leu His Glu Thr 
            260                 265                 270         


Pro Thr Thr Gly Asn His Tyr Pro Ser Asn His Gln Pro 
        275                 280                 285 


<210>  6489
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  6489

Met Arg Asn Ile Phe Lys Arg Asn Gln Glu Pro Ile Val Ala Pro Ala 
1               5                   10                  15      


Thr Thr Thr Ala Thr Met Pro Ile Gly Pro Val Asp Asn Ser Thr Glu 
            20                  25                  30          


Ser Gly Gly Ala Gly Glu Ser Gln Glu Asp Met Phe Ala Lys Leu Lys 
        35                  40                  45              


Glu Lys Leu Phe Asn Glu Ile Asn Lys Ile Pro Leu Pro Pro Trp Ala 
    50                  55                  60                  


Leu Ile Ala Ile Ala Val Val Ala Gly Leu Leu Leu Leu Thr Cys Cys 
65                  70                  75                  80  


Phe Cys Ile Cys Lys Lys Cys Cys Cys Lys Lys Lys Lys Asn Lys Lys 
                85                  90                  95      


Glu Lys Gly Lys Gly Met Lys Asn Ala Met Asn Met Lys Asp Met Lys 
            100                 105                 110         


Gly Gly Gln Asp Asp Asp Asp Ala Glu Thr Gly Leu Thr Glu Gly Glu 
        115                 120                 125             


Gly Glu Gly Glu Glu Glu Lys Glu Pro Glu Asn Leu Gly Lys Leu Gln 
    130                 135                 140                 


Phe Ser Leu Asp Tyr Asp Phe Gln Ala Asn Gln Leu Thr Val Gly Val 
145                 150                 155                 160 


Leu Gln Ala Ala Glu Leu Pro Ala Leu Asp Met Gly Gly Thr Ser Asp 
                165                 170                 175     


Pro Tyr Val Lys Val Phe Leu Leu Pro Asp Lys Lys Lys Lys Tyr Glu 
            180                 185                 190         


Thr Lys Val His Arg Lys Thr Leu Asn Pro Ala Phe Asn Glu Thr Phe 
        195                 200                 205             


Thr Phe Lys Val Pro Tyr Gln Glu Leu Gly Gly Lys Thr Leu Val Met 
    210                 215                 220                 


Ala Ile Tyr Asp Phe Asp Arg Phe Ser Lys His Asp Ile Ile Gly Glu 
225                 230                 235                 240 


Val Lys Val Pro Met Asn Thr Val Asp Leu Gly Gln Pro Ile Glu Glu 
                245                 250                 255     


Trp Arg Asp Leu Gln Gly Gly Glu Lys Glu Glu Pro Glu Lys Leu Gly 
            260                 265                 270         


Asp Ile Cys Thr Ser Leu Arg Tyr Val Pro Thr Ala Gly Lys Leu Thr 
        275                 280                 285             


Val Cys Ile Leu Glu Ala Lys Asn Leu Lys Lys Met Asp Val Gly Gly 
    290                 295                 300                 


Leu Ser Asp Pro Tyr Val Lys Ile His Leu Met Gln Asn Gly Lys Arg 
305                 310                 315                 320 


Leu Lys Lys Lys Lys Thr Thr Val Lys Lys Lys Thr Leu Asn Pro Tyr 
                325                 330                 335     


Phe Asn Glu Ser Phe Ser Phe Glu Ile Pro Phe Glu Gln Ile Gln Lys 
            340                 345                 350         


Val Gln Val Val Val Thr Val Leu Asp Tyr Asp Lys Leu Gly Lys Asn 
        355                 360                 365             


Glu Ala Ile Gly Lys Ile Phe Val Gly Ser Asn Ala Thr Gly Thr Glu 
    370                 375                 380                 


Leu Arg His Trp Ser Asp Met Leu Ala Asn Pro Arg Arg Pro Ile Ala 
385                 390                 395                 400 


Gln Trp His Ser Leu Lys Pro Glu Glu Glu Val Asp Ala Leu Leu Gly 
                405                 410                 415     


Lys Asn Lys 
            


<210>  6490
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  6490

Met Asp Ser Leu Glu Trp Asn Trp Ala Leu Val Tyr Glu Leu Ser Gly 
1               5                   10                  15      


Glu His His Asp Glu Glu Trp Ser Val Lys Thr Tyr Gln Glu Val Ala 
            20                  25                  30          


Gln Lys Phe Val Glu Thr His Pro Glu Phe Ile Gly Ile Lys Ile Ile 
        35                  40                  45              


Tyr Ser Asp His Arg Ser Lys Asp Val Ala Val Ile Ala Glu Ser Ile 
    50                  55                  60                  


Arg Met Ala Met Gly Leu Arg Ile Lys Phe Pro Thr Val Val Ala Gly 
65                  70                  75                  80  


Phe Asp Leu Val Gly His Glu Asp Thr Gly His Ser Leu His Asp Tyr 
                85                  90                  95      


Lys Glu Ala Leu Met Ile Pro Ala Lys Asp Gly Val Lys Leu Pro Tyr 
            100                 105                 110         


Phe Phe His Ala Gly Glu Thr Asp Trp Gln Gly Thr Ser Ile Asp Arg 
        115                 120                 125             


Asn Ile Leu Asp Ala Leu Met Leu Asn Thr Thr Arg Ile Gly His Gly 
    130                 135                 140                 


Phe Ala Leu Ser Lys His Pro Ala Val Arg Thr Tyr Ser Trp Lys Lys 
145                 150                 155                 160 


Asp Ile Pro Ile Glu Val Cys Pro Ile Ser Asn Gln Val Leu Lys Leu 
                165                 170                 175     


Val Ser Asp Leu Arg Asn His Pro Val Ala Thr Leu Met Ala Thr Gly 
            180                 185                 190         


His Pro Met Val Ile Ser Ser Asp Asp Pro Ala Met Phe Gly Ala Lys 
        195                 200                 205             


Gly Leu Ser Tyr Asp Phe Tyr Glu Val Phe Met Gly Ile Gly Gly Met 
    210                 215                 220                 


Lys Ala Asp Leu Arg Thr Leu Lys Gln Leu Ala Met Asn Ser Ile Lys 
225                 230                 235                 240 


Tyr Ser Thr Leu Leu Glu Ser Glu Lys Asn Thr Phe Met Glu Ile Trp 
                245                 250                 255     


Lys Lys Arg Trp Asp Lys Phe Ile Ala Asp Val Ala Thr Lys 
            260                 265                 270 


<210>  6491
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  6491

Met Gln Asn Tyr Lys Tyr Asp Lys Ala Ile Val Pro Glu Ser Lys Asn 
1               5                   10                  15      


Gly Gly Ser Pro Ala Leu Asn Asn Asn Pro Arg Arg Ser Gly Ser Lys 
            20                  25                  30          


Arg Val Leu Leu Ile Cys Leu Asp Leu Phe Cys Leu Phe Met Ala Gly 
        35                  40                  45              


Leu Pro Phe Leu Ile Ile Glu Thr Ser Thr Ile Lys Pro Tyr His Arg 
    50                  55                  60                  


Gly Phe Tyr Cys Asn Asp Glu Ser Ile Lys Tyr Pro Leu Lys Thr Gly 
65                  70                  75                  80  


Glu Thr Ile Asn Asp Ala Val Leu Cys Ala Val Gly Ile Val Ile Ala 
                85                  90                  95      


Ile Leu Ala Ile Ile Thr Gly Glu Phe Tyr Arg Ile Tyr Tyr Leu Lys 
            100                 105                 110         


Lys Ser Arg Ser Thr Ile Gln Asn Pro Tyr Val Ala Ala Leu Tyr Lys 
        115                 120                 125             


Gln Val Gly Cys Phe Leu Phe Gly Cys Ala Ile Ser Gln Ser Phe Thr 
    130                 135                 140                 


Asp Ile Ala Lys Val Ser Ile Gly Arg Leu Arg Pro His Phe Leu Ser 
145                 150                 155                 160 


Val Cys Asn Pro Asp Phe Ser Gln Ile Asn Cys Ser Glu Gly Tyr Ile 
                165                 170                 175     


Gln Asn Tyr Arg Cys Arg Gly Asp Asp Ser Lys Val Gln Glu Ala Arg 
            180                 185                 190         


Lys Ser Phe Phe Ser Gly His Ala Ser Phe Ser Met Tyr Thr Met Leu 
        195                 200                 205             


Tyr Leu Val Leu Tyr Leu Gln Ala Arg Phe Thr Trp Arg Gly Ala Arg 
    210                 215                 220                 


Leu Leu Arg Pro Leu Leu Gln Phe Thr Leu Ile Met Met Ala Phe Tyr 
225                 230                 235                 240 


Thr Gly Leu Ser Arg Val Ser Asp His Lys His His Pro Ser Asp Val 
                245                 250                 255     


Leu Ala Gly Phe Ala Gln Gly Ala Leu Val Ala Cys Cys Ile Val Phe 
            260                 265                 270         


Phe Val Ser Asp Leu Phe Lys Thr Lys Thr Thr Leu Ser Leu Pro Ala 
        275                 280                 285             


Pro Ala Ile Arg Lys Glu Ile Leu Ser Pro Val Asp Ile Ile Asp Arg 
    290                 295                 300                 


Asn Asn His His Asn Met Met 
305                 310     


<210>  6492
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  6492

Met Ser Tyr Gly Pro Leu Asp Met Tyr Arg Asn Pro Gly Pro Ser Gly 
1               5                   10                  15      


Pro Gln Leu Arg Asp Phe Ser Ser Ile Ile Gln Thr Cys Ser Gly Asn 
            20                  25                  30          


Ile Gln Arg Ile Ser Gln Ala Thr Ala Gln Ile Lys Asn Leu Met Ser 
        35                  40                  45              


Gln Leu Gly Thr Lys Gln Asp Ser Ser Lys Leu Gln Glu Asn Leu Gln 
    50                  55                  60                  


Gln Leu Gln His Ser Thr Asn Gln Leu Ala Lys Glu Thr Asn Glu Leu 
65                  70                  75                  80  


Leu Lys Glu Leu Gly Ser Leu Pro Leu Pro Leu Ser Thr Ser Glu Gln 
                85                  90                  95      


Arg Gln Gln Arg Leu Gln Lys Glu Arg Leu Met Asn Asp Phe Ser Ala 
            100                 105                 110         


Ala Leu Asn Asn Phe Gln Ala Val Gln Arg Arg Val Ser Glu Lys Glu 
        115                 120                 125             


Lys Glu Ser Ile Ala Arg Ala Arg Ala Gly Ser Arg Leu Ser Ala Glu 
    130                 135                 140                 


Glu Arg Gln Arg Glu Glu Gln Leu Val Ser Phe Asp Ser His Glu Glu 
145                 150                 155                 160 


Trp Asn Gln Met Gln Ser Gln Glu Asp Glu Val Ala Ile Thr Glu Gln 
                165                 170                 175     


Asp Leu Glu Leu Ile Lys Glu Arg Glu Thr Ala Ile Arg Gln Leu Glu 
            180                 185                 190         


Ala Asp Ile Leu Asp Val Asn Gln Ile Phe Lys Asp Leu Ala Met Met 
        195                 200                 205             


Ile His Asp Gln Gly Asp Leu Ile Asp Ser Ile Glu Ala Asn Val Glu 
    210                 215                 220                 


Ser Ser Glu Val His Val Glu Arg Ala Thr Glu Gln Leu Gln Arg Ala 
225                 230                 235                 240 


Ala Tyr Tyr Gln Lys Lys Ser Arg Lys Lys Met Cys Ile Leu Val Leu 
                245                 250                 255     


Val Leu Ser Val Ile Ile Leu Ile Leu Gly Leu Ile Ile Trp Leu Val 
            260                 265                 270         


Tyr Lys Thr Lys 
        275     


<210>  6493
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  6493

Met Glu Leu Ser Asp Val Thr Leu Ile Glu Gly Val Gly Asn Glu Val 
1               5                   10                  15      


Met Val Val Ala Gly Val Val Val Leu Ile Leu Ala Leu Val Leu Ala 
            20                  25                  30          


Trp Leu Ser Thr Tyr Val Ala Asp Ser Gly Ser Asn Gln Leu Leu Gly 
        35                  40                  45              


Ala Ile Val Ser Ala Gly Asp Thr Ser Val Leu His Leu Gly His Val 
    50                  55                  60                  


Asp His Leu Val Ala Gly Gln Gly Asn Pro Glu Pro Thr Glu Leu Pro 
65                  70                  75                  80  


His Pro Ser Glu Gly Asn Asp Glu Lys Ala Glu Glu Ala Gly Glu Gly 
                85                  90                  95      


Arg Gly Asp Ser Thr Gly Glu Ala Gly Ala Gly Gly Gly Val Glu Pro 
            100                 105                 110         


Ser Leu Glu His Leu Leu Asp Ile Gln Gly Leu Pro Lys Arg Gln Ala 
        115                 120                 125             


Gly Ala Gly Ser Ser Ser Pro Glu Ala Pro Leu Arg Ser Glu Asp Ser 
    130                 135                 140                 


Thr Cys Leu Pro Pro Ser Pro Gly Leu Ile Thr Val Arg Leu Lys Phe 
145                 150                 155                 160 


Leu Asn Asp Thr Glu Glu Leu Ala Val Ala Arg Pro Glu Asp Thr Val 
                165                 170                 175     


Gly Ala Leu Lys Ser Lys Tyr Phe Pro Gly Gln Glu Ser Gln Met Lys 
            180                 185                 190         


Leu Ile Tyr Gln Gly Arg Leu Leu Gln Asp Pro Ala Arg Thr Leu Arg 
        195                 200                 205             


Ser Leu Asn Ile Thr Asp Asn Cys Val Ile His Cys His Arg Ser Pro 
    210                 215                 220                 


Pro Gly Ser Ala Val Pro Gly Pro Ser Ala Ser Leu Ala Pro Ser Ala 
225                 230                 235                 240 


Thr Glu Pro Pro Ser Leu Gly Val Asn Val Gly Ser Leu Met Val Pro 
                245                 250                 255     


Val Phe Val Val Leu Leu Gly Val Val Trp Tyr Phe Arg Ile Asn Tyr 
            260                 265                 270         


Arg Gln Phe Phe Thr Ala Pro Ala Thr Val Ser Leu Val Gly Val Thr 
        275                 280                 285             


Val Phe Phe Ser Phe Leu Val Phe Gly Met Tyr Gly Arg 
    290                 295                 300     


<210>  6494
<211>  826
<212>  PRT
<213>  Homo sapiens

<400>  6494

Met Ala Arg Leu Cys Arg Arg Val Pro Cys Thr Leu Leu Leu Gly Leu 
1               5                   10                  15      


Ala Val Val Leu Leu Lys Ala Arg Leu Val Pro Ala Ala Ala Arg Ala 
            20                  25                  30          


Glu Leu Ser Arg Ser Asp Leu Ser Leu Ile Gln Gln Gln Gln Gln Gln 
        35                  40                  45              


Gln Gln Gln Gln Gln Gln Gln Gln Lys Gln Leu Glu Glu Ala Glu Glu 
    50                  55                  60                  


Glu Arg Thr Glu Val Pro Gly Ala Thr Ser Thr Leu Thr Val Pro Val 
65                  70                  75                  80  


Ser Val Phe Met Leu Lys Val Gln Val Asn Asp Ile Ile Ser Arg Gln 
                85                  90                  95      


Tyr Leu Ser Gln Ala Val Val Glu Val Phe Val Asn Tyr Thr Lys Thr 
            100                 105                 110         


Asn Ser Thr Val Thr Lys Ser Asn Gly Ala Val Leu Ile Lys Val Pro 
        115                 120                 125             


Tyr Lys Leu Gly Leu Ser Leu Thr Ile Ile Ala Tyr Lys Asp Gly Tyr 
    130                 135                 140                 


Val Leu Thr Pro Leu Pro Trp Lys Thr Arg Arg Met Pro Ile Tyr Ser 
145                 150                 155                 160 


Ser Val Thr Leu Ser Leu Phe Pro Gln Ser Gln Ala Asn Ile Trp Leu 
                165                 170                 175     


Phe Glu Asp Thr Val Leu Ile Thr Gly Lys Leu Ala Asp Ala Lys Ser 
            180                 185                 190         


Gln Pro Ser Val Gln Phe Ser Lys Ala Leu Ile Lys Leu Pro Asp Asn 
        195                 200                 205             


His His Ile Ser Asn Val Thr Gly Tyr Leu Thr Val Leu Gln Gln Phe 
    210                 215                 220                 


Leu Lys Val Asp Asn Phe Leu His Thr Thr Gly Ile Thr Leu Asn Lys 
225                 230                 235                 240 


Pro Gly Phe Glu Asn Ile Glu Leu Thr Pro Leu Ala Ala Ile Cys Val 
                245                 250                 255     


Lys Ile Tyr Ser Gly Gly Lys Glu Leu Lys Val Asn Gly Ser Ile Gln 
            260                 265                 270         


Val Ser Leu Pro Leu Leu Arg Leu Asn Asp Ile Ser Ala Gly Asp Arg 
        275                 280                 285             


Ile Pro Ala Trp Thr Phe Asp Met Asn Thr Gly Ala Trp Val Asn His 
    290                 295                 300                 


Gly Arg Gly Met Val Lys Glu His Asn Asn His Leu Ile Trp Thr Tyr 
305                 310                 315                 320 


Asp Ala Pro His Leu Gly Tyr Trp Ile Ala Ala Pro Leu Pro Gly Thr 
                325                 330                 335     


Arg Gly Ser Gly Ile Asn Glu Asp Ser Lys Asp Ile Thr Ala Tyr His 
            340                 345                 350         


Thr Val Phe Leu Thr Ala Ile Leu Gly Gly Thr Ile Val Ile Val Ile 
        355                 360                 365             


Gly Phe Phe Ala Val Leu Leu Cys Tyr Cys Arg Asp Lys Cys Gly Thr 
    370                 375                 380                 


Pro Gln Lys Arg Glu Arg Asn Ile Thr Lys Leu Glu Val Leu Lys Arg 
385                 390                 395                 400 


Asp Gln Thr Thr Ser Thr Thr His Ile Asn His Ile Ser Thr Val Lys 
                405                 410                 415     


Val Ala Leu Lys Ala Glu Asp Lys Ser Gln Leu Phe Asn Ala Lys Asn 
            420                 425                 430         


Ser Ser Tyr Ser Pro Gln Lys Lys Glu Pro Ser Lys Ala Glu Thr Glu 
        435                 440                 445             


Glu Arg Val Ser Met Val Lys Thr Arg Asp Asp Phe Lys Ile Tyr Asn 
    450                 455                 460                 


Glu Asp Val Ser Phe Leu Ser Val Asn Gln Asn Asn Tyr Ser Arg Asn 
465                 470                 475                 480 


Pro Thr Gln Ser Leu Glu Pro Asn Val Gly Ser Lys Gln Pro Lys His 
                485                 490                 495     


Ile Asn Asn Asn Leu Ser Ser Ser Leu Gly Asp Ala Gln Asp Glu Lys 
            500                 505                 510         


Arg Tyr Leu Thr Gly Asn Glu Glu Ala Tyr Gly Arg Ser His Ile Pro 
        515                 520                 525             


Glu Gln Leu Met His Ile Tyr Ser Gln Pro Ile Ala Ile Leu Gln Thr 
    530                 535                 540                 


Ser Asp Leu Phe Ser Thr Pro Glu Gln Leu His Thr Ala Lys Ser Ala 
545                 550                 555                 560 


Thr Leu Pro Arg Lys Gly Gln Leu Val Tyr Gly Gln Leu Met Glu Pro 
                565                 570                 575     


Val Asn Arg Glu Asn Phe Thr Gln Thr Leu Pro Lys Met Pro Ile His 
            580                 585                 590         


Ser His Ala Gln Pro Pro Asp Ala Arg Glu Glu Asp Ile Ile Leu Glu 
        595                 600                 605             


Gly Gln Gln Ser Leu Pro Ser Gln Ala Ser Asp Trp Ser Arg Tyr Ser 
    610                 615                 620                 


Ser Ser Leu Leu Glu Ser Val Ser Val Pro Gly Thr Leu Asn Glu Ala 
625                 630                 635                 640 


Val Val Met Thr Pro Phe Ser Ser Glu Leu Gln Gly Ile Ser Glu Gln 
                645                 650                 655     


Thr Leu Leu Glu Leu Ser Lys Gly Lys Pro Ser Pro His Pro Arg Ala 
            660                 665                 670         


Trp Phe Val Ser Leu Asp Gly Lys Pro Val Ala Gln Val Arg His Ser 
        675                 680                 685             


Phe Ile Asp Leu Lys Lys Gly Lys Arg Thr Gln Ser Asn Asp Thr Ser 
    690                 695                 700                 


Leu Asp Ser Gly Val Asp Met Asn Glu Leu His Ser Ser Arg Lys Leu 
705                 710                 715                 720 


Glu Arg Glu Lys Thr Phe Ile Lys Ser Met His Gln Pro Lys Ile Leu 
                725                 730                 735     


Tyr Leu Glu Asp Leu Asp Leu Ser Ser Ser Glu Ser Gly Thr Thr Val 
            740                 745                 750         


Cys Ser Pro Glu Asp Pro Ala Leu Arg His Ile Leu Asp Gly Gly Ser 
        755                 760                 765             


Gly Val Ile Met Glu His Pro Gly Glu Glu Ser Pro Gly Arg Lys Ser 
    770                 775                 780                 


Thr Val Glu Asp Phe Glu Ala Asn Thr Ser Pro Thr Lys Arg Arg Gly 
785                 790                 795                 800 


Arg Pro Pro Leu Ala Lys Arg Asp Ser Lys Thr Asn Ile Trp Lys Lys 
                805                 810                 815     


Arg Glu Glu Arg Pro Leu Ile Pro Ile Asn 
            820                 825     


<210>  6495
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  6495

Met Ala Gly Val Thr Ile Thr Ala Thr Val Ile Leu Val Ser Ala Gly 
1               5                   10                  15      


Glu Ala Tyr Leu Val Tyr Thr Asp Arg Leu Tyr Ser Arg Ser Asp Phe 
            20                  25                  30          


Asn Asn Tyr Val Ala Ala Val Tyr Lys Val Leu Gly Thr Phe Leu Phe 
        35                  40                  45              


Gly Ala Ala Val Ser Gln Ser Leu Thr Asp Leu Ala Lys Tyr Met Ile 
    50                  55                  60                  


Gly Arg Leu Arg Pro Asn Phe Leu Ala Val Cys Asp Pro Asp Trp Ser 
65                  70                  75                  80  


Arg Val Asn Cys Ser Val Tyr Val Gln Leu Glu Lys Val Cys Arg Gly 
                85                  90                  95      


Asn Pro Ala Asp Val Thr Glu Ala Arg Leu Ser Phe Tyr Ser Gly His 
            100                 105                 110         


Ser Ser Phe Gly Met Tyr Cys Met Val Phe Leu Ala Leu Tyr Val Gln 
        115                 120                 125             


Ala Arg Leu Cys Trp Lys Trp Ala Arg Leu Leu Arg Pro Thr Val Gln 
    130                 135                 140                 


Phe Phe Leu Val Ala Phe Ala Leu Tyr Val Gly Tyr Thr Arg Val Ser 
145                 150                 155                 160 


Asp Tyr Lys His His Trp Ser Asp Val Leu Val Gly Leu Leu Gln Gly 
                165                 170                 175     


Ala Leu Val Ala Ala Leu Thr Val Cys Tyr Ile Ser Asp Phe Phe Lys 
            180                 185                 190         


Ala Arg Pro Pro Gln His Cys Leu Lys Glu Glu Glu Leu Glu Arg Lys 
        195                 200                 205             


Pro Ser Leu Ser Leu Thr Leu Thr Leu Gly Glu Ala Asp His Asn His 
    210                 215                 220                 


Tyr Gly Tyr Pro His Ser Ser Ser 
225                 230         


<210>  6496
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  6496

Met Leu Asp Phe Ala Ile Phe Ala Val Thr Phe Leu Leu Ala Leu Val 
1               5                   10                  15      


Gly Ala Val Leu Tyr Leu Tyr Pro Ala Ser Arg Gln Ala Ala Gly Ile 
            20                  25                  30          


Pro Gly Ile Thr Pro Thr Glu Glu Lys Asp Gly Asn Leu Pro Asp Ile 
        35                  40                  45              


Val Asn Ser Gly Ser Leu His Glu Phe Leu Val Asn Leu His Glu Arg 
    50                  55                  60                  


Tyr Gly Pro Val Val Ser Phe Trp Phe Gly Arg Arg Leu Val Val Ser 
65                  70                  75                  80  


Leu Gly Thr Val Asp Val Leu Lys Gln His Ile Asn Pro Asn Lys Thr 
                85                  90                  95      


Ser Asp Pro Phe Glu Thr Met Leu Lys Ser Leu Leu Arg Tyr Gln Ser 
            100                 105                 110         


Gly Gly Gly Ser Val Ser Glu Asn His Met Arg Lys Lys Leu Tyr Glu 
        115                 120                 125             


Asn Gly Val Thr Asp Ser Leu Lys Ser Asn Phe Ala Leu Leu Leu Lys 
    130                 135                 140                 


Leu Ser Glu Glu Leu Leu Asp Lys Trp Leu Ser Tyr Pro Glu Thr Gln 
145                 150                 155                 160 


His Val Pro Leu Ser Gln His Met Leu Gly Phe Ala Met Lys Ser Val 
                165                 170                 175     


Thr Gln Met Val Met Gly Ser Thr Phe Glu Asp Asp Gln Glu Val Ile 
            180                 185                 190         


Arg Phe Gln Lys Asn His Gly Thr Val Trp Ser Glu Ile Gly Lys Gly 
        195                 200                 205             


Phe Leu Asp Gly Ser Leu Asp Lys Asn Met Thr Arg Lys Lys Gln Tyr 
    210                 215                 220                 


Glu Asp Ala Leu Met Gln Leu Glu Ser Val Leu Arg Asn Ile Ile Lys 
225                 230                 235                 240 


Glu Arg Lys Gly Arg Asn Phe Ser Gln His Ile Phe Ile Asp Ser Leu 
                245                 250                 255     


Val Gln Gly Asn Leu Asn Asp Gln Gln Ile Leu Glu Asp Ser Met Ile 
            260                 265                 270         


Phe Ser Leu Ala Ser Cys Ile Ile Thr Ala Lys Leu Cys Thr Trp Ala 
        275                 280                 285             


Ile Cys Phe Leu Thr Thr Ser Glu Glu Val Gln Lys Lys Leu Tyr Glu 
    290                 295                 300                 


Glu Ile Asn Gln Val Phe Gly Asn Gly Pro Val Thr Pro Glu Lys Ile 
305                 310                 315                 320 


Glu Gln Leu Arg Tyr Cys Gln His Val Leu Cys Glu Thr Val Arg Thr 
                325                 330                 335     


Ala Lys Leu Thr Pro Val Ser Ala Gln Leu Gln Asp Ile Glu Gly Lys 
            340                 345                 350         


Ile Asp Arg Phe Ile Ile Pro Arg Glu Thr Leu Val Leu Tyr Ala Leu 
        355                 360                 365             


Gly Val Val Leu Gln Asp Pro Asn Thr Trp Pro Ser Pro His Lys Phe 
    370                 375                 380                 


Asp Pro Asp Arg Phe Asp Asp Glu Leu Val Met Lys Thr Phe Ser Ser 
385                 390                 395                 400 


Leu Gly Phe Ser Gly Thr Gln Glu Cys Pro Glu Leu Arg Phe Ala Tyr 
                405                 410                 415     


Met Val Thr Thr Val Leu Leu Ser Val Leu Val Lys Arg Leu His Leu 
            420                 425                 430         


Leu Ser Val Glu Gly Gln Val Ile Glu Thr Lys Tyr Glu Leu Val Thr 
        435                 440                 445             


Ser Ser Arg Glu Glu Ala Trp Ile Thr Val Ser Lys Arg Tyr 
    450                 455                 460         


<210>  6497
<211>  587
<212>  PRT
<213>  Homo sapiens

<400>  6497

Met Leu Leu Cys Thr Ala Arg Leu Val Gly Leu Gln Leu Leu Ile Ser 
1               5                   10                  15      


Cys Cys Trp Ala Phe Ala Cys His Ser Thr Glu Ser Ser Pro Asp Phe 
            20                  25                  30          


Thr Leu Pro Gly Asp Tyr Leu Leu Ala Gly Leu Phe Pro Leu His Ser 
        35                  40                  45              


Gly Cys Leu Gln Val Arg His Arg Pro Glu Val Thr Leu Cys Asp Arg 
    50                  55                  60                  


Ser Cys Ser Phe Asn Glu His Gly Tyr His Leu Phe Gln Ala Met Arg 
65                  70                  75                  80  


Leu Gly Val Glu Glu Ile Asn Asn Ser Thr Ala Leu Leu Pro Asn Ile 
                85                  90                  95      


Thr Leu Gly Tyr Gln Leu Tyr Asp Val Cys Ser Asp Ser Ala Asn Val 
            100                 105                 110         


Tyr Ala Thr Leu Arg Val Leu Ser Leu Pro Gly Gln His His Ile Glu 
        115                 120                 125             


Leu Gln Gly Asp Leu Leu His Tyr Ser Pro Thr Val Leu Ala Val Ile 
    130                 135                 140                 


Gly Pro Asp Ser Thr Asn Arg Ala Ala Thr Thr Ala Ala Leu Leu Ser 
145                 150                 155                 160 


Pro Phe Leu Val Pro Met Leu Leu Glu Gln Ile His Lys Val His Phe 
                165                 170                 175     


Leu Leu His Lys Asp Thr Val Ala Phe Asn Asp Asn Arg Asp Pro Leu 
            180                 185                 190         


Ser Ser Tyr Asn Ile Ile Ala Trp Asp Trp Asn Gly Pro Lys Trp Thr 
        195                 200                 205             


Phe Thr Val Leu Gly Ser Ser Thr Trp Ser Pro Val Gln Leu Asn Ile 
    210                 215                 220                 


Asn Glu Thr Lys Ile Gln Trp His Gly Lys Asp Asn Gln Val Pro Lys 
225                 230                 235                 240 


Ser Val Cys Ser Ser Asp Cys Leu Glu Gly His Gln Arg Val Val Thr 
                245                 250                 255     


Gly Phe His His Cys Cys Phe Glu Cys Val Pro Cys Gly Ala Gly Thr 
            260                 265                 270         


Phe Leu Asn Lys Ser Asp Leu Tyr Arg Cys Gln Pro Cys Gly Lys Glu 
        275                 280                 285             


Glu Trp Ala Pro Glu Gly Ser Gln Thr Cys Phe Pro Arg Thr Val Val 
    290                 295                 300                 


Phe Leu Ala Leu Arg Glu His Thr Ser Trp Val Leu Leu Ala Ala Asn 
305                 310                 315                 320 


Thr Leu Leu Leu Leu Leu Leu Leu Gly Thr Ala Gly Leu Phe Ala Trp 
                325                 330                 335     


His Leu Asp Thr Pro Val Val Arg Ser Ala Gly Gly Arg Leu Cys Phe 
            340                 345                 350         


Leu Met Leu Gly Ser Leu Ala Ala Gly Ser Gly Ser Leu Tyr Gly Phe 
        355                 360                 365             


Phe Gly Glu Pro Thr Arg Pro Ala Cys Leu Leu Arg Gln Ala Leu Phe 
    370                 375                 380                 


Ala Leu Gly Phe Thr Ile Phe Leu Ser Cys Leu Thr Val Arg Ser Phe 
385                 390                 395                 400 


Gln Leu Ile Ile Ile Phe Lys Phe Ser Thr Lys Val Pro Thr Phe Tyr 
                405                 410                 415     


His Ala Trp Val Gln Asn His Gly Ala Gly Leu Phe Val Met Ile Ser 
            420                 425                 430         


Ser Ala Ala Gln Leu Leu Ile Cys Leu Thr Trp Leu Val Val Trp Thr 
        435                 440                 445             


Pro Leu Pro Ala Arg Glu Tyr Gln Arg Phe Pro His Leu Val Met Leu 
    450                 455                 460                 


Glu Cys Thr Glu Thr Asn Ser Leu Gly Phe Ile Leu Ala Phe Leu Tyr 
465                 470                 475                 480 


Asn Gly Leu Leu Ser Ile Ser Ala Phe Ala Cys Ser Tyr Leu Gly Lys 
                485                 490                 495     


Asp Leu Pro Glu Asn Tyr Asn Glu Ala Lys Cys Val Thr Phe Ser Leu 
            500                 505                 510         


Leu Phe Asn Phe Val Ser Trp Ile Ala Phe Phe Thr Thr Ala Ser Val 
        515                 520                 525             


Tyr Asp Gly Lys Tyr Leu Pro Ala Ala Asn Met Met Ala Gly Leu Ser 
    530                 535                 540                 


Ser Leu Ser Ser Gly Phe Gly Gly Tyr Phe Leu Pro Lys Cys Tyr Val 
545                 550                 555                 560 


Ile Leu Cys Arg Pro Asp Leu Asn Ser Thr Glu His Phe Gln Ala Ser 
                565                 570                 575     


Ile Gln Asp Tyr Thr Arg Arg Cys Gly Ser Thr 
            580                 585         


<210>  6498
<211>  587
<212>  PRT
<213>  Homo sapiens

<400>  6498

Met Leu Leu Cys Thr Ala Arg Leu Val Gly Leu Gln Leu Leu Ile Ser 
1               5                   10                  15      


Cys Cys Trp Ala Phe Ala Cys His Ser Thr Glu Ser Ser Pro Asp Phe 
            20                  25                  30          


Thr Leu Pro Gly Asp Tyr Leu Leu Ala Gly Leu Phe Pro Leu His Ser 
        35                  40                  45              


Gly Cys Leu Gln Val Arg His Arg Pro Glu Val Thr Leu Cys Asp Arg 
    50                  55                  60                  


Ser Cys Ser Phe Asn Glu His Gly Tyr His Leu Phe Gln Ala Met Arg 
65                  70                  75                  80  


Leu Gly Val Glu Glu Ile Asn Asn Ser Thr Ala Leu Leu Pro Asn Ile 
                85                  90                  95      


Thr Leu Gly Tyr Gln Leu Tyr Asp Val Cys Ser Asp Ser Ala Asn Val 
            100                 105                 110         


Tyr Ala Thr Leu Arg Val Leu Ser Leu Pro Gly Gln His His Ile Glu 
        115                 120                 125             


Leu Gln Gly Asp Leu Leu His Tyr Ser Pro Thr Val Leu Ala Val Ile 
    130                 135                 140                 


Gly Pro Asp Ser Thr Asn Arg Ala Ala Thr Thr Ala Ala Leu Leu Ser 
145                 150                 155                 160 


Pro Phe Leu Val Pro Met Leu Leu Glu Gln Ile His Lys Val His Phe 
                165                 170                 175     


Leu Leu His Lys Asp Thr Val Ala Phe Asn Asp Asn Arg Asp Pro Leu 
            180                 185                 190         


Ser Ser Tyr Asn Ile Ile Ala Trp Asp Trp Asn Gly Pro Lys Trp Thr 
        195                 200                 205             


Phe Thr Val Leu Gly Ser Ser Thr Trp Ser Pro Val Gln Leu Asn Ile 
    210                 215                 220                 


Asn Glu Thr Lys Ile Gln Trp His Gly Lys Asp Asn Gln Val Pro Lys 
225                 230                 235                 240 


Ser Val Cys Ser Ser Asp Cys Leu Glu Gly His Gln Arg Val Val Thr 
                245                 250                 255     


Gly Phe His His Cys Cys Phe Glu Cys Val Pro Cys Gly Ala Gly Thr 
            260                 265                 270         


Phe Leu Asn Lys Ser Asp Leu Tyr Arg Cys Gln Pro Cys Gly Lys Glu 
        275                 280                 285             


Glu Trp Ala Pro Glu Gly Ser Gln Thr Cys Phe Pro Arg Thr Val Val 
    290                 295                 300                 


Phe Leu Ala Leu Arg Glu His Thr Ser Trp Val Leu Leu Ala Ala Asn 
305                 310                 315                 320 


Thr Leu Leu Leu Leu Leu Leu Leu Gly Thr Ala Gly Leu Phe Ala Trp 
                325                 330                 335     


His Leu Asp Thr Pro Val Val Arg Ser Ala Gly Gly Arg Leu Cys Phe 
            340                 345                 350         


Leu Met Leu Gly Ser Leu Ala Ala Gly Ser Gly Ser Leu Tyr Gly Phe 
        355                 360                 365             


Phe Gly Glu Pro Thr Arg Pro Ala Cys Leu Leu Arg Gln Ala Leu Phe 
    370                 375                 380                 


Ala Leu Gly Phe Thr Ile Phe Leu Ser Cys Leu Thr Val Arg Ser Phe 
385                 390                 395                 400 


Gln Leu Ile Ile Ile Phe Lys Phe Ser Thr Lys Val Pro Thr Phe Tyr 
                405                 410                 415     


His Ala Trp Val Gln Asn His Gly Ala Gly Leu Phe Val Met Ile Ser 
            420                 425                 430         


Ser Ala Ala Gln Leu Leu Ile Cys Leu Thr Trp Leu Val Val Trp Thr 
        435                 440                 445             


Pro Leu Pro Ala Arg Glu Tyr Gln Arg Phe Pro His Leu Val Met Leu 
    450                 455                 460                 


Glu Cys Thr Glu Thr Asn Ser Leu Gly Phe Ile Leu Ala Phe Leu Tyr 
465                 470                 475                 480 


Asn Gly Leu Leu Ser Ile Ser Ala Phe Ala Cys Ser Tyr Leu Gly Lys 
                485                 490                 495     


Asp Leu Pro Glu Asn Tyr Asn Glu Ala Lys Cys Val Thr Phe Ser Leu 
            500                 505                 510         


Leu Phe Asn Phe Val Ser Trp Ile Ala Phe Phe Thr Thr Ala Ser Val 
        515                 520                 525             


Tyr Asp Gly Lys Tyr Leu Pro Ala Ala Asn Met Met Ala Gly Leu Ser 
    530                 535                 540                 


Ser Leu Ser Ser Gly Phe Gly Gly Tyr Phe Leu Pro Lys Cys Tyr Val 
545                 550                 555                 560 


Ile Leu Cys Arg Pro Asp Leu Asn Ser Thr Glu His Phe Gln Ala Ser 
                565                 570                 575     


Ile Gln Asp Tyr Thr Arg Arg Cys Gly Ser Thr 
            580                 585         


<210>  6499
<211>  587
<212>  PRT
<213>  Homo sapiens

<400>  6499

Met Leu Leu Cys Thr Ala Arg Leu Val Gly Leu Gln Leu Leu Ile Ser 
1               5                   10                  15      


Cys Cys Trp Ala Phe Ala Cys His Ser Thr Glu Ser Ser Pro Asp Phe 
            20                  25                  30          


Thr Leu Pro Gly Asp Tyr Leu Leu Ala Gly Leu Phe Pro Leu His Ser 
        35                  40                  45              


Gly Cys Leu Gln Val Arg His Arg Pro Glu Val Thr Leu Cys Asp Arg 
    50                  55                  60                  


Ser Cys Ser Phe Asn Glu His Gly Tyr His Leu Phe Gln Ala Met Arg 
65                  70                  75                  80  


Leu Gly Val Glu Glu Ile Asn Asn Ser Thr Ala Leu Leu Pro Asn Ile 
                85                  90                  95      


Thr Leu Gly Tyr Gln Leu Tyr Asp Val Cys Ser Asp Ser Ala Asn Val 
            100                 105                 110         


Tyr Ala Thr Leu Arg Val Leu Ser Leu Pro Gly Gln His His Ile Glu 
        115                 120                 125             


Leu Gln Gly Asp Leu Leu His Tyr Ser Pro Thr Val Leu Ala Val Ile 
    130                 135                 140                 


Gly Pro Asp Ser Thr Asn Arg Ala Ala Thr Thr Ala Ala Leu Leu Ser 
145                 150                 155                 160 


Pro Phe Leu Val Pro Met Leu Leu Glu Gln Ile His Lys Val His Phe 
                165                 170                 175     


Leu Leu His Lys Asp Thr Val Ala Phe Asn Asp Asn Arg Asp Pro Leu 
            180                 185                 190         


Ser Ser Tyr Asn Ile Ile Ala Trp Asp Trp Asn Gly Pro Lys Trp Thr 
        195                 200                 205             


Phe Thr Val Leu Gly Ser Ser Thr Trp Ser Pro Val Gln Leu Asn Ile 
    210                 215                 220                 


Asn Glu Thr Lys Ile Gln Trp His Gly Lys Asp Asn Gln Val Pro Lys 
225                 230                 235                 240 


Ser Val Cys Ser Ser Asp Cys Leu Glu Gly His Gln Arg Val Val Thr 
                245                 250                 255     


Gly Phe His His Cys Cys Phe Glu Cys Val Pro Cys Gly Ala Gly Thr 
            260                 265                 270         


Phe Leu Asn Lys Ser Asp Leu Tyr Arg Cys Gln Pro Cys Gly Lys Glu 
        275                 280                 285             


Glu Trp Ala Pro Glu Gly Ser Gln Thr Cys Phe Pro Arg Thr Val Val 
    290                 295                 300                 


Phe Leu Ala Leu Arg Glu His Thr Ser Trp Val Leu Leu Ala Ala Asn 
305                 310                 315                 320 


Thr Leu Leu Leu Leu Leu Leu Leu Gly Thr Ala Gly Leu Phe Ala Trp 
                325                 330                 335     


His Leu Asp Thr Pro Val Val Arg Ser Ala Gly Gly Arg Leu Cys Phe 
            340                 345                 350         


Leu Met Leu Gly Ser Leu Ala Ala Gly Ser Gly Ser Leu Tyr Gly Phe 
        355                 360                 365             


Phe Gly Glu Pro Thr Arg Pro Ala Cys Leu Leu Arg Gln Ala Leu Phe 
    370                 375                 380                 


Ala Leu Gly Phe Thr Ile Phe Leu Ser Cys Leu Thr Val Arg Ser Phe 
385                 390                 395                 400 


Gln Leu Ile Ile Ile Phe Lys Phe Ser Thr Lys Val Pro Thr Phe Tyr 
                405                 410                 415     


His Ala Trp Val Gln Asn His Gly Ala Gly Leu Phe Val Met Ile Ser 
            420                 425                 430         


Ser Ala Ala Gln Leu Leu Ile Cys Leu Thr Trp Leu Val Val Trp Thr 
        435                 440                 445             


Pro Leu Pro Ala Arg Glu Tyr Gln Arg Phe Pro His Leu Val Met Leu 
    450                 455                 460                 


Glu Cys Thr Glu Thr Asn Ser Leu Gly Phe Ile Leu Ala Phe Leu Tyr 
465                 470                 475                 480 


Asn Gly Leu Leu Ser Ile Ser Ala Phe Ala Cys Ser Tyr Leu Gly Lys 
                485                 490                 495     


Asp Leu Pro Glu Asn Tyr Asn Glu Ala Lys Cys Val Thr Phe Ser Leu 
            500                 505                 510         


Leu Phe Asn Phe Val Ser Trp Ile Ala Phe Phe Thr Thr Ala Ser Val 
        515                 520                 525             


Tyr Asp Gly Lys Tyr Leu Pro Ala Ala Asn Met Met Ala Gly Leu Ser 
    530                 535                 540                 


Ser Leu Ser Ser Gly Phe Gly Gly Tyr Phe Leu Pro Lys Cys Tyr Val 
545                 550                 555                 560 


Ile Leu Cys Arg Pro Asp Leu Asn Ser Thr Glu His Phe Gln Ala Ser 
                565                 570                 575     


Ile Gln Asp Tyr Thr Arg Arg Cys Gly Ser Thr 
            580                 585         


<210>  6500
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  6500

Met Gly Val Ala Arg Gly Pro Gly Ser Arg Gly Gln His Pro Pro Pro 
1               5                   10                  15      


Arg Gln Gln Glu Val Cys Ala Glu Gly Pro Arg Ala Arg Leu His Pro 
            20                  25                  30          


Ala Pro Pro Gly Leu Gly Ala Ser Leu Pro Phe Ala Ile Leu Thr Leu 
        35                  40                  45              


Val Asn Ala Pro Tyr Lys Arg Gly Phe Tyr Cys Gly Asp Asp Ser Ile 
    50                  55                  60                  


Arg Tyr Pro Tyr Arg Pro Asp Thr Ile Thr His Gly Leu Met Ala Gly 
65                  70                  75                  80  


Val Thr Ile Thr Ala Thr Val Ile Leu Val Ser Ala Gly Glu Ala Tyr 
                85                  90                  95      


Leu Val Tyr Thr Asp Arg Leu Tyr Ser Arg Ser Asp Phe Asn Asn Tyr 
            100                 105                 110         


Val Ala Ala Val Tyr Lys Val Leu Gly Thr Phe Leu Phe Gly Ala Ala 
        115                 120                 125             


Val Ser Gln Ser Leu Thr Asp Leu Ala Lys Tyr Met Ile Gly Arg Leu 
    130                 135                 140                 


Arg Pro Asn Phe Leu Ala Val Cys Asp Pro Asp Trp Ser Arg Val Asn 
145                 150                 155                 160 


Cys Ser Val Tyr Val Gln Leu Glu Lys Val Cys Arg Gly Asn Pro Ala 
                165                 170                 175     


Asp Val Thr Glu Ala Arg Leu Ser Phe Tyr Ser Gly His Ser Ser Phe 
            180                 185                 190         


Gly Met Tyr Cys Met Val Phe Leu Ala Leu Tyr Val Gln Ala Arg Leu 
        195                 200                 205             


Cys Trp Lys Trp Ala Arg Leu Leu Arg Pro Thr Val Gln Phe Phe Leu 
    210                 215                 220                 


Val Ala Phe Ala Leu Tyr Val Gly Tyr Thr Arg Val Ser Asp Tyr Lys 
225                 230                 235                 240 


His His Trp Ser Asp Val Leu Val Gly Leu Leu Gln Gly Ala Leu Val 
                245                 250                 255     


Ala Ala Leu Thr Val Cys Tyr Ile Ser Asp Phe Phe Lys Ala Arg Pro 
            260                 265                 270         


Pro Gln His Cys Leu Lys Glu Glu Glu Leu Glu Arg Lys Pro Ser Leu 
        275                 280                 285             


Ser Leu Thr Leu Thr Leu Gly Glu Ala Asp His Asn His Tyr Gly Tyr 
    290                 295                 300                 


Pro His Ser Ser Ser 
305                 


<210>  6501
<211>  568
<212>  PRT
<213>  Homo sapiens

<400>  6501

Met Ala Ser Ala Leu Ser Tyr Val Ser Lys Phe Lys Ser Phe Val Ile 
1               5                   10                  15      


Leu Phe Val Thr Pro Leu Leu Leu Leu Pro Leu Val Ile Leu Met Pro 
            20                  25                  30          


Ala Lys Phe Val Arg Cys Ala Tyr Val Ile Ile Leu Met Ala Ile Tyr 
        35                  40                  45              


Trp Cys Thr Glu Val Ile Pro Leu Ala Val Thr Ser Leu Met Pro Val 
    50                  55                  60                  


Leu Leu Phe Pro Leu Phe Gln Ile Leu Asp Ser Arg Gln Val Cys Val 
65                  70                  75                  80  


Gln Tyr Met Lys Asp Thr Asn Met Leu Phe Leu Gly Gly Leu Ile Val 
                85                  90                  95      


Ala Val Ala Val Glu Arg Trp Asn Leu His Lys Arg Ile Ala Leu Arg 
            100                 105                 110         


Thr Leu Leu Trp Val Gly Ala Lys Pro Ala Arg Leu Met Leu Gly Phe 
        115                 120                 125             


Met Gly Val Thr Ala Leu Leu Ser Met Trp Ile Ser Asn Thr Ala Thr 
    130                 135                 140                 


Thr Ala Met Met Val Pro Ile Val Glu Ala Ile Leu Gln Gln Met Glu 
145                 150                 155                 160 


Ala Thr Ser Ala Ala Thr Glu Ala Gly Leu Glu Leu Val Asp Lys Gly 
                165                 170                 175     


Lys Ala Lys Glu Leu Pro Gly Ser Gln Val Ile Phe Glu Gly Pro Thr 
            180                 185                 190         


Leu Gly Gln Gln Glu Asp Gln Glu Arg Lys Arg Leu Cys Lys Ala Met 
        195                 200                 205             


Thr Leu Cys Ile Cys Tyr Ala Ala Ser Ile Gly Gly Thr Ala Thr Leu 
    210                 215                 220                 


Thr Gly Thr Gly Pro Asn Val Val Leu Leu Gly Gln Met Asn Glu Leu 
225                 230                 235                 240 


Phe Pro Asp Ser Lys Asp Leu Val Asn Phe Ala Ser Trp Phe Ala Phe 
                245                 250                 255     


Ala Phe Pro Asn Met Leu Val Met Leu Leu Phe Ala Trp Leu Trp Leu 
            260                 265                 270         


Gln Phe Val Tyr Met Arg Phe Asn Phe Lys Lys Ser Trp Gly Cys Gly 
        275                 280                 285             


Leu Glu Ser Lys Lys Asn Glu Lys Ala Ala Leu Lys Val Leu Gln Glu 
    290                 295                 300                 


Glu Tyr Arg Lys Leu Gly Pro Leu Ser Phe Ala Glu Ile Asn Val Leu 
305                 310                 315                 320 


Ile Cys Phe Phe Leu Leu Val Ile Leu Trp Phe Ser Arg Asp Pro Gly 
                325                 330                 335     


Phe Met Pro Gly Trp Leu Thr Val Ala Trp Val Glu Gly Glu Thr Lys 
            340                 345                 350         


Tyr Val Ser Asp Ala Thr Val Ala Ile Phe Val Ala Thr Leu Leu Phe 
        355                 360                 365             


Ile Val Pro Ser Gln Lys Pro Lys Phe Asn Phe Arg Ser Gln Thr Glu 
    370                 375                 380                 


Glu Glu Arg Lys Thr Pro Phe Tyr Pro Pro Pro Leu Leu Asp Trp Lys 
385                 390                 395                 400 


Val Thr Gln Glu Lys Val Pro Trp Gly Ile Val Leu Leu Leu Gly Gly 
                405                 410                 415     


Gly Phe Ala Leu Ala Lys Gly Ser Glu Ala Ser Gly Leu Ser Val Trp 
            420                 425                 430         


Met Gly Lys Gln Met Glu Pro Leu His Ala Val Pro Pro Ala Ala Ile 
        435                 440                 445             


Thr Leu Ile Leu Ser Leu Leu Val Ala Val Phe Thr Glu Cys Thr Ser 
    450                 455                 460                 


Asn Val Ala Thr Thr Thr Leu Phe Leu Pro Ile Phe Ala Ser Met Ser 
465                 470                 475                 480 


Arg Ser Ile Gly Leu Asn Pro Leu Tyr Ile Met Leu Pro Cys Thr Leu 
                485                 490                 495     


Ser Ala Ser Phe Ala Phe Met Leu Pro Val Ala Thr Pro Pro Asn Ala 
            500                 505                 510         


Ile Val Phe Thr Tyr Gly His Leu Lys Val Ala Asp Met Val Lys Thr 
        515                 520                 525             


Gly Val Ile Met Asn Ile Ile Gly Val Phe Cys Val Phe Leu Ala Val 
    530                 535                 540                 


Asn Thr Trp Gly Arg Ala Ile Phe Asp Leu Asp His Phe Pro Asp Trp 
545                 550                 555                 560 


Ala Asn Val Thr His Ile Glu Thr 
                565             


<210>  6502
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  6502

Met Met Gly Leu Gly Asn Gly Arg Arg Ser Met Lys Ser Pro Pro Leu 
1               5                   10                  15      


Val Leu Ala Ala Leu Val Ala Cys Ile Ile Val Leu Gly Phe Asn Tyr 
            20                  25                  30          


Trp Ile Ala Ser Ser Arg Ser Val Asp Leu Gln Thr Arg Ile Met Glu 
        35                  40                  45              


Leu Glu Gly Arg Val Arg Arg Ala Ala Ala Glu Arg Gly Ala Val Glu 
    50                  55                  60                  


Leu Lys Lys Asn Glu Phe Gln Gly Glu Leu Glu Lys Gln Arg Glu Gln 
65                  70                  75                  80  


Leu Asp Lys Ile Gln Ser Ser His Asn Phe Gln Leu Glu Ser Val Asn 
                85                  90                  95      


Lys Leu Tyr Gln Asp Glu Lys Ala Val Leu Val Asn Asn Ile Thr Thr 
            100                 105                 110         


Gly Glu Arg Leu Ile Arg Val Leu Gln Asp Gln Leu Lys Thr Leu Gln 
        115                 120                 125             


Arg Asn Tyr Gly Arg Leu Gln Gln Asp Val Leu Gln Phe Gln Lys Asn 
    130                 135                 140                 


Gln Thr Asn Leu Glu Arg Lys Phe Ser Tyr Asp Leu Ser Gln Cys Ile 
145                 150                 155                 160 


Asn Gln Met Lys Glu Val Lys Glu Gln Cys Glu Glu Arg Ile Glu Glu 
                165                 170                 175     


Val Thr Lys Lys Gly Asn Glu Ala Val Ala Ser Arg Asp Leu Ser Glu 
            180                 185                 190         


Asn Asn Asp Gln Arg Gln Gln Leu Gln Ala Leu Ser Glu Pro Gln Pro 
        195                 200                 205             


Arg Leu Gln Ala Ala Gly Leu Pro His Thr Glu Val Pro Gln Gly Lys 
    210                 215                 220                 


Gly Asn Val Leu Gly Asn Ser Lys Ser Gln Thr Pro Ala Pro Ser Ser 
225                 230                 235                 240 


Glu Val Val Leu Asp Ser Lys Arg Gln Val Glu Lys Glu Glu Thr Asn 
                245                 250                 255     


Glu Ile Gln Val Val Asn Glu Glu Pro Gln Arg Asp Arg Leu Pro Gln 
            260                 265                 270         


Glu Pro Gly Arg Glu Gln Val Val Glu Asp Arg Pro Val Gly Gly Arg 
        275                 280                 285             


Gly Phe Gly Gly Ala Gly Glu Leu Gly Gln Thr Pro Gln Val Gln Ala 
    290                 295                 300                 


Ala Leu Ser Val Ser Gln Glu Asn Pro Glu Met Glu Gly Pro Glu Arg 
305                 310                 315                 320 


Asp Gln Leu Val Ile Pro Asp Gly Gln Glu Glu Glu Gln Glu Ala Ala 
                325                 330                 335     


Gly Glu Gly Arg Asn Gln Gln Lys Leu Arg Gly Glu Asp Asp Tyr Asn 
            340                 345                 350         


Met Asp Glu Asn Glu Ala Glu Ser Glu Thr Asp Lys Gln Ala Ala Leu 
        355                 360                 365             


Ala Gly Asn Asp Arg Asn Ile Asp Val Phe Asn Val Glu Asp Gln Lys 
    370                 375                 380                 


Arg Asp Thr Ile Asn Leu Leu Asp Gln Arg Glu Lys Arg Asn His Thr 
385                 390                 395                 400 


Leu 
    


<210>  6503
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  6503

Met Ala Ala Ala Ala Val Thr Gly Gln Arg Pro Glu Thr Ala Ala Ala 
1               5                   10                  15      


Glu Glu Ala Ser Arg Pro Gln Trp Ala Pro Pro Asp His Cys Gln Ala 
            20                  25                  30          


Gln Ala Ala Ala Gly Leu Gly Asp Gly Glu Asp Ala Pro Val Arg Pro 
        35                  40                  45              


Leu Cys Lys Pro Arg Gly Ile Cys Ser Arg Ala Tyr Phe Leu Val Leu 
    50                  55                  60                  


Met Val Phe Val His Leu Tyr Leu Gly Asn Val Leu Ala Leu Leu Leu 
65                  70                  75                  80  


Phe Val His Tyr Ser Asn Gly Asp Glu Ser Ser Asp Pro Gly Pro Gln 
                85                  90                  95      


His Arg Ala Gln Gly Pro Gly Pro Glu Pro Thr Leu Gly Pro Leu Thr 
            100                 105                 110         


Arg Leu Glu Gly Ile Lys Val Gly His Glu Arg Lys Val Gln Leu Val 
        115                 120                 125             


Thr Asp Arg Asp His Phe Ile Arg Thr Leu Ser Leu Lys Pro Leu Leu 
    130                 135                 140                 


Phe Glu Ile Pro Gly Phe Leu Thr Asp Glu Glu Cys Arg Leu Ile Ile 
145                 150                 155                 160 


His Leu Ala Gln Met Lys Gly Leu Gln Arg Ser Gln Ile Leu Pro Thr 
                165                 170                 175     


Glu Glu Tyr Glu Glu Ala Met Ser Thr Met Gln Val Ser Gln Leu Asp 
            180                 185                 190         


Leu Phe Arg Leu Leu Asp Gln Asn Arg Asp Gly His Leu Gln Leu Arg 
        195                 200                 205             


Glu Val Leu Ala Gln Thr Arg Leu Gly Asn Gly Trp Trp Met Thr Pro 
    210                 215                 220                 


Glu Ser Ile Gln Glu Met Tyr Ala Ala Ile Lys Ala Asp Pro Asp Gly 
225                 230                 235                 240 


Asp Gly Val Leu Ser Leu Gln Glu Phe Ser Asn Met Asp Leu Arg Asp 
                245                 250                 255     


Phe His Lys Tyr Met Arg Ser His Lys Ala Glu Ser Ser Glu Leu Val 
            260                 265                 270         


Arg Asn Ser His His Thr Trp Leu Tyr Gln Gly Glu Gly Ala His His 
        275                 280                 285             


Ile Met Arg Ala Ile Arg Gln Arg Val Leu Arg Leu Thr Arg Leu Ser 
    290                 295                 300                 


Pro Glu Ile Val Glu Leu Ser Glu Pro Leu Gln Val Val Arg Tyr Gly 
305                 310                 315                 320 


Glu Gly Gly His Tyr His Ala His Val Asp Ser Gly Pro Val Tyr Pro 
                325                 330                 335     


Glu Thr Ile Cys Ser His Thr Lys Leu Val Ala Asn Glu Ser Val Pro 
            340                 345                 350         


Phe Glu Thr Ser Cys Arg Gln Val Ser Pro Asn Trp Gly Leu Pro Ser 
        355                 360                 365             


Ile Leu Arg Pro Gly Thr Pro Met Thr Gln Ala Gln Pro Cys Thr Val 
    370                 375                 380                 


Gly Val Pro Leu Gly Met Gly Pro Gly Asp His Trp Val Ile Pro Val 
385                 390                 395                 400 


Ser Pro Trp Glu His Pro Gln Leu Gly Thr Cys Ser Val Pro Pro Leu 
                405                 410                 415     


Pro Tyr Ser Tyr Met Thr Val Leu Phe Tyr Leu Asn Asn Val Thr Gly 
            420                 425                 430         


Gly Gly Glu Thr Val Phe Pro Val Ala Asp Asn Arg Thr Tyr Asp Glu 
        435                 440                 445             


Met Ser Leu Ile Gln Asp Asp Val Asp Leu Arg Asp Thr Arg Arg His 
    450                 455                 460                 


Cys Asp Lys Gly Asn Leu Arg Val Lys Pro Gln Gln Gly Thr Ala Val 
465                 470                 475                 480 


Phe Trp Tyr Asn Tyr Leu Pro Asp Gly Gln Gly Trp Val Gly Asp Val 
                485                 490                 495     


Asp Asp Tyr Ser Leu His Gly Gly Cys Leu Val Thr Arg Gly Thr Lys 
            500                 505                 510         


Trp Ile Ala Asn Asn Trp Ile Asn Val Asp Pro Ser Arg Ala Arg Gln 
        515                 520                 525             


Ala Leu Phe Gln Gln Glu Met Ala Arg Leu Ala Arg Glu Gly Gly Thr 
    530                 535                 540                 


Asp Ser Gln Pro Glu Trp Ala Leu Asp Arg Ala Tyr Arg Asp Ala Arg 
545                 550                 555                 560 


Val Glu Leu 
            


<210>  6504
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  6504

Met Ala Ala Ala Ala Val Thr Gly Gln Arg Pro Glu Thr Ala Ala Ala 
1               5                   10                  15      


Glu Glu Ala Ser Arg Pro Gln Trp Ala Pro Pro Asp His Cys Gln Ala 
            20                  25                  30          


Gln Ala Ala Ala Gly Leu Gly Asp Gly Glu Asp Ala Pro Val Arg Pro 
        35                  40                  45              


Leu Cys Lys Pro Arg Gly Ile Cys Ser Arg Ala Tyr Phe Leu Val Leu 
    50                  55                  60                  


Met Val Phe Val His Leu Tyr Leu Gly Asn Val Leu Ala Leu Leu Leu 
65                  70                  75                  80  


Phe Val His Tyr Ser Asn Gly Asp Glu Ser Ser Asp Pro Gly Pro Gln 
                85                  90                  95      


His Arg Ala Gln Gly Pro Gly Pro Glu Pro Thr Leu Gly Pro Leu Thr 
            100                 105                 110         


Arg Leu Glu Gly Ile Lys Val Gly His Glu Arg Lys Val Gln Leu Val 
        115                 120                 125             


Thr Asp Arg Asp His Phe Ile Arg Thr Leu Ser Leu Lys Pro Leu Leu 
    130                 135                 140                 


Phe Glu Ile Pro Gly Phe Leu Thr Asp Glu Glu Cys Arg Leu Ile Ile 
145                 150                 155                 160 


His Leu Ala Gln Met Lys Gly Leu Gln Arg Ser Gln Ile Leu Pro Thr 
                165                 170                 175     


Glu Glu Tyr Glu Glu Ala Met Ser Thr Met Gln Val Ser Gln Leu Asp 
            180                 185                 190         


Leu Phe Arg Leu Leu Asp Gln Asn Arg Asp Gly His Leu Gln Leu Arg 
        195                 200                 205             


Glu Val Leu Ala Gln Thr Arg Leu Gly Asn Gly Trp Trp Met Thr Pro 
    210                 215                 220                 


Glu Ser Ile Gln Glu Met Tyr Ala Ala Ile Lys Ala Asp Pro Asp Gly 
225                 230                 235                 240 


Asp Gly Val Leu Ser Leu Gln Glu Phe Ser Asn Met Asp Leu Arg Asp 
                245                 250                 255     


Phe His Lys Tyr Met Arg Ser His Lys Ala Glu Ser Ser Glu Leu Val 
            260                 265                 270         


Arg Asn Ser His His Thr Trp Leu Tyr Gln Gly Glu Gly Ala His His 
        275                 280                 285             


Ile Met Arg Ala Ile Arg Gln Arg Val Leu Arg Leu Thr Arg Leu Ser 
    290                 295                 300                 


Pro Glu Ile Val Glu Leu Ser Glu Pro Leu Gln Val Val Arg Tyr Gly 
305                 310                 315                 320 


Glu Gly Gly His Tyr His Ala His Val Asp Ser Gly Pro Val Tyr Pro 
                325                 330                 335     


Glu Thr Ile Cys Ser His Thr Lys Leu Val Ala Asn Glu Ser Val Pro 
            340                 345                 350         


Phe Glu Thr Ser Cys Arg Tyr Met Thr Val Leu Phe Tyr Leu Asn Asn 
        355                 360                 365             


Val Thr Gly Gly Gly Glu Thr Val Phe Pro Val Ala Asp Asn Arg Thr 
    370                 375                 380                 


Tyr Asp Glu Met Ser Leu Ile Gln Asp Asp Val Asp Leu Arg Asp Thr 
385                 390                 395                 400 


Arg Arg His Cys Asp Lys Gly Asn Leu Arg Val Lys Pro Gln Gln Gly 
                405                 410                 415     


Thr Ala Val Phe Trp Tyr Asn Tyr Leu Pro Asp Gly Gln Gly Trp Val 
            420                 425                 430         


Gly Asp Val Asp Asp Tyr Ser Leu His Gly Gly Cys Leu Val Thr Arg 
        435                 440                 445             


Gly Thr Lys Trp Ile Ala Asn Asn Trp Ile Asn Val Asp Pro Ser Arg 
    450                 455                 460                 


Ala Arg Gln Ala Leu Phe Gln Gln Glu Met Ala Arg Leu Ala Arg Glu 
465                 470                 475                 480 


Gly Gly Thr Asp Ser Gln Pro Glu Trp Ala Leu Asp Arg Ala Tyr Arg 
                485                 490                 495     


Asp Ala Arg Val Glu Leu 
            500         


<210>  6505
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  6505

Met Gly Tyr Ala Arg Lys Val Gly Trp Val Thr Ala Gly Leu Val Ile 
1               5                   10                  15      


Gly Ala Gly Ala Cys Tyr Cys Ile Tyr Arg Leu Thr Arg Gly Arg Lys 
            20                  25                  30          


Gln Asn Lys Glu Lys Met Ala Glu Gly Gly Ser Gly Asp Val Asp Asp 
        35                  40                  45              


Ala Gly Asp Cys Ser Gly Ala Arg Tyr Asn Asp Trp Ser Asp Asp Asp 
    50                  55                  60                  


Asp Asp Ser Asn Glu Ser Lys Ser Ile Val Trp Tyr Pro Pro Trp Ala 
65                  70                  75                  80  


Arg Ile Gly Thr Glu Ala Gly Thr Arg Ala Arg Ala Arg Ala Arg Ala 
                85                  90                  95      


Arg Ala Thr Arg Ala Arg Arg Ala Val Gln Lys Arg Ala Ser Pro Asn 
            100                 105                 110         


Ser Asp Asp Thr Val Leu Ser Pro Gln Glu Leu Gln Lys Val Leu Cys 
        115                 120                 125             


Leu Val Glu Met Ser Glu Lys Pro Tyr Ile Leu Glu Ala Ala Leu Ile 
    130                 135                 140                 


Ala Leu Gly Asn Asn Ala Ala Tyr Ala Phe Asn Arg Asp Ile Ile Arg 
145                 150                 155                 160 


Asp Leu Gly Gly Leu Pro Ile Val Ala Lys Ile Leu Asn Thr Arg Asp 
                165                 170                 175     


Pro Ile Val Lys Glu Lys Ala Leu Ile Val Leu Asn Asn Leu Ser Val 
            180                 185                 190         


Asn Ala Glu Asn Gln Arg Arg Leu Lys Val Tyr Met Asn Gln Val Cys 
        195                 200                 205             


Asp Asp Thr Ile Thr Ser Arg Leu Asn Ser Ser Val Gln Leu Ala Gly 
    210                 215                 220                 


Leu Arg Leu Leu Thr Asn Met Thr Val Thr Asn Glu Tyr Gln His Met 
225                 230                 235                 240 


Leu Ala Asn Ser Ile Ser Asp Phe Phe Arg Leu Phe Ser Ala Gly Asn 
                245                 250                 255     


Glu Glu Thr Lys Leu Gln Val Leu Lys Leu Leu Leu Asn Leu Ala Glu 
            260                 265                 270         


Asn Pro Ala Met Thr Arg Glu Leu Leu Arg Ala Gln Val Pro Ser Ser 
        275                 280                 285             


Leu Gly Ser Leu Phe Asn Lys Lys Glu Asn Lys Glu Val Ile Leu Lys 
    290                 295                 300                 


Leu Leu Val Ile Phe Glu Asn Ile Asn Asp Asn Phe Lys Trp Glu Glu 
305                 310                 315                 320 


Asn Glu Pro Thr Gln Asn Gln Phe Gly Glu Gly Ser Leu Phe Phe Phe 
                325                 330                 335     


Leu Lys Glu Phe Gln Val Cys Ala Asp Lys Val Leu Gly Ile Glu Ser 
            340                 345                 350         


His His Asp Phe Leu Val Lys Val Lys Val Gly Lys Phe Met Ala Lys 
        355                 360                 365             


Leu Ala Glu His Met Phe Pro Lys Ser Gln Glu 
    370                 375                 


<210>  6506
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  6506

Met Gly Tyr Ala Arg Lys Val Gly Trp Val Thr Ala Gly Leu Val Ile 
1               5                   10                  15      


Gly Ala Gly Ala Cys Tyr Cys Ile Tyr Arg Leu Thr Arg Gly Arg Lys 
            20                  25                  30          


Gln Asn Lys Glu Lys Met Ala Glu Gly Gly Ser Gly Asp Val Asp Asp 
        35                  40                  45              


Ala Gly Asp Cys Ser Gly Ala Arg Tyr Asn Asp Trp Ser Asp Asp Asp 
    50                  55                  60                  


Asp Asp Ser Asn Glu Ser Lys Ser Ile Val Trp Tyr Pro Pro Trp Ala 
65                  70                  75                  80  


Arg Ile Gly Thr Glu Ala Gly Thr Arg Ala Arg Ala Arg Ala Arg Ala 
                85                  90                  95      


Arg Ala Thr Arg Ala Arg Arg Ala Val Gln Lys Arg Ala Ser Pro Asn 
            100                 105                 110         


Ser Asp Asp Thr Val Leu Ser Pro Gln Glu Leu Gln Lys Val Leu Cys 
        115                 120                 125             


Leu Val Glu Met Ser Glu Lys Pro Tyr Ile Leu Glu Ala Ala Leu Ile 
    130                 135                 140                 


Ala Leu Gly Asn Asn Ala Ala Tyr Ala Phe Asn Arg Asp Ile Ile Arg 
145                 150                 155                 160 


Asp Leu Gly Gly Leu Pro Ile Val Ala Lys Ile Leu Asn Thr Arg Asp 
                165                 170                 175     


Pro Ile Val Lys Glu Lys Ala Leu Ile Val Leu Asn Asn Leu Ser Val 
            180                 185                 190         


Asn Ala Glu Asn Gln Arg Arg Leu Lys Val Tyr Met Asn Gln Val Cys 
        195                 200                 205             


Asp Asp Thr Ile Thr Ser Arg Leu Asn Ser Ser Val Gln Leu Ala Gly 
    210                 215                 220                 


Leu Arg Leu Leu Thr Asn Met Thr Val Thr Asn Glu Tyr Gln His Met 
225                 230                 235                 240 


Leu Ala Asn Ser Ile Ser Asp Phe Phe Arg Leu Phe Ser Ala Gly Asn 
                245                 250                 255     


Glu Glu Thr Lys Leu Gln Val Leu Lys Leu Leu Leu Asn Leu Ala Glu 
            260                 265                 270         


Asn Pro Ala Met Thr Arg Glu Leu Leu Arg Ala Gln Val Pro Ser Ser 
        275                 280                 285             


Leu Gly Ser Leu Phe Asn Lys Lys Glu Asn Lys Glu Val Ile Leu Lys 
    290                 295                 300                 


Leu Leu Val Ile Phe Glu Asn Ile Asn Asp Asn Phe Lys Trp Glu Glu 
305                 310                 315                 320 


Asn Glu Pro Thr Gln Asn Gln Phe Gly Glu Gly Ser Leu Phe Phe Phe 
                325                 330                 335     


Leu Lys Glu Phe Gln Val Cys Ala Asp Lys Val Leu Gly Ile Glu Ser 
            340                 345                 350         


His His Asp Phe Leu Val Lys Val Lys Val Gly Lys Phe Met Ala Lys 
        355                 360                 365             


Leu Ala Glu His Met Phe Pro Lys Ser Gln Glu 
    370                 375                 


<210>  6507
<211>  632
<212>  PRT
<213>  Homo sapiens

<400>  6507

Met Ser Arg Val Arg Asp Ala Gly Cys Val Ala Ala Gly Ile Val Ile 
1               5                   10                  15      


Gly Ala Gly Ala Trp Tyr Cys Val Tyr Lys Tyr Thr Arg Gly Arg Asp 
            20                  25                  30          


Gln Thr Lys Lys Arg Met Ala Lys Pro Lys Asn Arg Ala Val Ala Gly 
        35                  40                  45              


Thr Gly Ala Arg Ala Arg Ala Gly Leu Arg Ala Gly Phe Thr Ile Asp 
    50                  55                  60                  


Leu Gly Ser Gly Phe Ser Pro Pro Thr Pro Val Arg Ala Glu Ala Glu 
65                  70                  75                  80  


Asp Arg Ala Gln Asp Glu Ala Ser Ala Leu Asp Thr Val Gly Ala Glu 
                85                  90                  95      


Ala Val Ala Pro Ala Ala Ser Ser Ala Glu Ala Gln Ser Gly Ala Gly 
            100                 105                 110         


Ser Gln Ala Gln Glu Ala Asp Gly Ala Gly Val Gly Pro Lys Ala Glu 
        115                 120                 125             


Ser Val Val Gly Ala Ala Met Ala Ser Ala Ile Ala Pro Pro Pro Gly 
    130                 135                 140                 


Val Thr Glu Ala Leu Gly Ala Ala Glu Ala Pro Ala Met Ala Gly Ala 
145                 150                 155                 160 


Pro Lys Val Ala Glu Ala Pro Arg Glu Ala Glu Thr Ser Arg Ala Ala 
                165                 170                 175     


Val Pro Pro Gly Thr Val Val Pro Thr Glu Ala Ala Ala Pro Thr Glu 
            180                 185                 190         


Val Thr Glu Gly Pro Gly Val Ala Ala Pro Thr Lys Val Ala Glu Ala 
        195                 200                 205             


Pro Gly Val Ala Ser Pro Thr Glu Ala Ala Glu Ala Pro Val Pro Ala 
    210                 215                 220                 


Thr Pro Thr Gly Ala Ala Ala Pro Thr Gly Ala Ala Glu Ser Pro Gly 
225                 230                 235                 240 


Thr Ser Gly Ser Pro Arg Thr Ala Val Val Pro Gly Thr Ser Ala Ala 
                245                 250                 255     


Lys Lys Ala Thr Pro Gly Ala His Thr Gly Ala Ile Pro Lys Ala Thr 
            260                 265                 270         


Ser Ala Thr Gly Ala Val Pro Lys Gly Gly Gly Lys Gly Val Thr Arg 
        275                 280                 285             


Ser Arg Asn Gly Gly Lys Gly Lys Gly Lys Lys Ser Lys Val Glu Val 
    290                 295                 300                 


Asp Glu Leu Gly Met Gly Phe Arg Pro Gly Asp Gly Ala Ala Ala Ala 
305                 310                 315                 320 


Ala Ala Ala Ser Ala Asn Gly Gly Gln Ala Phe Leu Ala Glu Val Pro 
                325                 330                 335     


Asp Ser Glu Glu Gly Glu Ser Gly Trp Thr Asp Thr Glu Ser Asp Ser 
            340                 345                 350         


Asp Ser Glu Pro Glu Thr Gln Arg Arg Gly Arg Gly Arg Arg Pro Val 
        355                 360                 365             


Ala Met Gln Lys Arg Pro Phe Pro Tyr Glu Ile Asp Glu Ile Leu Gly 
    370                 375                 380                 


Val Arg Asp Leu Arg Lys Val Leu Ala Leu Leu Gln Lys Ser Asp Asp 
385                 390                 395                 400 


Pro Phe Ile Gln Gln Val Ala Leu Leu Thr Leu Ser Asn Asn Ala Asn 
                405                 410                 415     


Tyr Ser Cys Asn Gln Glu Thr Ile Arg Lys Leu Gly Gly Leu Pro Ile 
            420                 425                 430         


Ile Ala Asn Met Ile Asn Lys Thr Asp Pro His Ile Lys Glu Lys Ala 
        435                 440                 445             


Leu Met Ala Met Asn Asn Leu Ser Glu Asn Tyr Glu Asn Gln Gly Arg 
    450                 455                 460                 


Leu Gln Val Tyr Met Asn Lys Val Met Asp Asp Ile Met Ala Ser Asn 
465                 470                 475                 480 


Leu Asn Ser Ala Val Gln Val Val Gly Leu Lys Phe Leu Thr Asn Met 
                485                 490                 495     


Thr Ile Thr Asn Asp Tyr Gln His Leu Leu Val Asn Ser Ile Ala Asn 
            500                 505                 510         


Phe Phe Arg Leu Leu Ser Gln Gly Gly Gly Lys Ile Lys Val Glu Ile 
        515                 520                 525             


Leu Lys Ile Leu Ser Asn Phe Ala Glu Asn Pro Asp Met Leu Lys Lys 
    530                 535                 540                 


Leu Leu Ser Thr Gln Val Pro Ala Ser Phe Ser Ser Leu Tyr Asn Ser 
545                 550                 555                 560 


Tyr Val Glu Ser Glu Ile Leu Ile Asn Ala Leu Thr Leu Phe Glu Ile 
                565                 570                 575     


Ile Tyr Asp Asn Leu Arg Ala Glu Val Phe Asn Tyr Arg Glu Phe Asn 
            580                 585                 590         


Lys Gly Ser Leu Phe Tyr Leu Cys Thr Thr Ser Gly Val Cys Val Lys 
        595                 600                 605             


Lys Ile Arg Ala Leu Ala Asn His His Asp Leu Leu Val Lys Val Lys 
    610                 615                 620                 


Val Ile Lys Leu Val Asn Lys Phe 
625                 630         


<210>  6508
<211>  421
<212>  PRT
<213>  Homo sapiens

<400>  6508

Met Ala Val Asp Val Ala Glu Tyr His Leu Ser Val Ile Lys Ser Pro 
1               5                   10                  15      


Pro Gly Trp Glu Val Gly Val Tyr Ala Ala Gly Ala Leu Ala Leu Leu 
            20                  25                  30          


Gly Ile Ala Ala Val Ser Leu Trp Lys Leu Trp Thr Ser Gly Ser Phe 
        35                  40                  45              


Pro Ser Pro Ser Pro Phe Pro Asn Tyr Asp Tyr Arg Tyr Leu Gln Gln 
    50                  55                  60                  


Lys Tyr Gly Glu Ser Cys Ala Glu Ala Arg Glu Lys Arg Val Pro Ala 
65                  70                  75                  80  


Trp Asn Ala Gln Arg Ala Ser Thr Arg Gly Pro Pro Ser Arg Lys Gly 
                85                  90                  95      


Ser Leu Ser Ile Glu Asp Thr Phe Glu Ser Ile Ser Glu Leu Gly Pro 
            100                 105                 110         


Leu Glu Leu Met Gly Arg Glu Leu Asp Leu Ala Pro Tyr Gly Thr Leu 
        115                 120                 125             


Arg Lys Ser Gln Ser Ala Asp Ser Leu Asn Ser Ile Ser Ser Val Ser 
    130                 135                 140                 


Asn Thr Phe Gly Gln Asp Phe Thr Leu Gly Gln Val Glu Val Ser Met 
145                 150                 155                 160 


Glu Tyr Asp Thr Ala Ser His Thr Leu Asn Val Ala Val Met Gln Gly 
                165                 170                 175     


Lys Asp Leu Leu Glu Arg Glu Glu Ala Ser Phe Glu Ser Cys Phe Met 
            180                 185                 190         


Arg Val Ser Leu Leu Pro Asp Glu Gln Ile Val Gly Ile Ser Arg Ile 
        195                 200                 205             


Gln Arg Asn Ala Tyr Ser Ile Phe Phe Asp Glu Lys Phe Ser Ile Pro 
    210                 215                 220                 


Leu Asp Pro Thr Ala Leu Glu Glu Lys Ser Leu Arg Phe Ser Val Phe 
225                 230                 235                 240 


Gly Ile Asp Glu Asp Glu Arg Asn Val Ser Thr Gly Val Val Glu Leu 
                245                 250                 255     


Lys Leu Ser Val Leu Asp Leu Pro Leu Gln Pro Phe Ser Gly Trp Leu 
            260                 265                 270         


Tyr Leu Gln Asp Gln Asn Lys Ala Ala Asp Ala Val Gly Glu Ile Leu 
        275                 280                 285             


Leu Ser Leu Ser Tyr Leu Pro Thr Ala Glu Arg Leu Thr Val Val Val 
    290                 295                 300                 


Val Lys Ala Lys Asn Leu Ile Trp Thr Asn Asp Lys Thr Thr Ala Asp 
305                 310                 315                 320 


Pro Phe Val Lys Val Tyr Leu Leu Gln Asp Gly Arg Lys Met Ser Lys 
                325                 330                 335     


Lys Lys Thr Ala Val Lys Arg Asp Asp Pro Asn Pro Val Phe Asn Glu 
            340                 345                 350         


Ala Met Ile Phe Ser Val Pro Ala Ile Val Leu Gln Asp Leu Ser Leu 
        355                 360                 365             


Arg Val Thr Val Ala Glu Ser Ser Ser Asp Gly Arg Gly Asp Asn Val 
    370                 375                 380                 


Gly His Val Ile Ile Gly Pro Ser Ala Ser Gly Met Gly Thr Thr His 
385                 390                 395                 400 


Trp Asn Gln Met Leu Ala Thr Leu Arg Arg Pro Val Ser Met Trp His 
                405                 410                 415     


Ala Val Arg Arg Asn 
            420     


<210>  6509
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  6509

Met Leu Leu Ile Thr Leu Ser Ala Asn Leu Phe Thr Val Pro Glu Arg 
1               5                   10                  15      


Ser Leu Thr Thr Thr Phe Ser Phe Ser Arg Tyr Lys Ser Ser Asp Arg 
            20                  25                  30          


Pro Ala His Lys Val Ser Met Leu Leu Leu Cys His Ala Leu Ala Ile 
        35                  40                  45              


Ala Val Val Gln Ile Val Ile Phe Ser Glu Ser Trp Ala Phe Ala Lys 
    50                  55                  60                  


Asn Ile Asn Phe Tyr Asn Val Arg Pro Pro Leu Asp Pro Thr Pro Phe 
65                  70                  75                  80  


Pro Asn Ser Phe Lys Cys Phe Thr Cys Glu Asn Ala Gly Asp Asn Tyr 
                85                  90                  95      


Asn Cys Asn Arg Trp Ala Glu Asp Lys Trp Cys Pro Gln Asn Thr Gln 
            100                 105                 110         


Tyr Cys Leu Thr Val His His Phe Thr Ser His Gly Arg Ser Thr Ser 
        115                 120                 125             


Ile Thr Lys Lys Cys Ala Ser Arg Ser Glu Cys His Phe Val Gly Cys 
    130                 135                 140                 


His His Ser Arg Asp Ser Glu His Thr Glu Cys Arg Ser Cys Cys Glu 
145                 150                 155                 160 


Gly Met Ile Cys Asn Val Glu Leu Pro Thr Asn His Thr Asn Ala Val 
                165                 170                 175     


Phe Ala Val Met His Ala Gln Arg Thr Ser Gly Ser Ser Ala Pro Thr 
            180                 185                 190         


Leu Tyr Leu Pro Val Leu Ala Trp Val Phe Val Leu Pro Leu Leu 
        195                 200                 205         


<210>  6510
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  6510

Met Cys Phe Phe Phe Ser Leu Gln Glu Glu Phe Leu Asp Lys His Thr 
1               5                   10                  15      


Leu Met Arg Val Leu Ser Ser Gly Gly Lys Leu Gly Ser Arg Gly Glu 
            20                  25                  30          


Gly Ala Gln Leu Cys Cys Trp Met Leu Leu Phe Ser Trp Arg Val Ser 
        35                  40                  45              


Gly Gly Gln Gln Thr Arg Arg Leu Cys Arg Arg Ala Phe Cys Trp Ser 
    50                  55                  60                  


Pro Val Pro Ser Pro Ser Cys Ser Pro Ser Ser Cys Leu Thr Ala Arg 
65                  70                  75                  80  


Ser Ser Leu Cys Met Thr Phe Thr Gln Ser Arg Thr Thr Ser Ser Leu 
                85                  90                  95      


Ala Pro Val Phe Ala Leu Phe Val Pro Phe Tyr Cys Ser Ile Pro Arg 
            100                 105                 110         


Val Gln Val Ala Gln Ile Leu Gly Pro Leu Ser Ile Thr Asn Lys Thr 
        115                 120                 125             


Leu Ile Tyr Ile Leu Gly Leu Gln Leu Phe Thr Ser Gly Ser Tyr Ile 
    130                 135                 140                 


Trp Ile Val Ala Ile Ser Gly Leu Met Ser Gly Leu Cys Tyr Asp Ser 
145                 150                 155                 160 


Lys Met Phe Gln Val His Gln Val Leu Cys Ile Pro Ser Trp Met Ala 
                165                 170                 175     


Lys Phe Phe Ser Trp Thr Leu Glu Pro Ile Phe Ser Ser Ser Glu Pro 
            180                 185                 190         


Thr Ser Glu Ala Arg Ile Gly Met Gly Ala Thr Leu Asp Ile Gln Arg 
        195                 200                 205             


Gln Gln Arg Met Glu Leu Leu Asp Arg Gln Leu Met Phe Ser Gln Phe 
    210                 215                 220                 


Ala Gln Gly Arg Arg Gln Arg Gln Gln Gln Gly Gly Met Ile Asn Trp 
225                 230                 235                 240 


Asn Arg Leu Phe Pro Pro Leu Arg Gln Arg Gln Asn Val Asn Tyr Gln 
                245                 250                 255     


Gly Gly Arg Gln Ser Glu Pro Ala Ala Pro Pro Leu Glu Val Ser Glu 
            260                 265                 270         


Glu Gln Val Ala Arg Leu Met Glu Met Gly Phe Ser Arg Gly Asp Ala 
        275                 280                 285             


Leu Glu Ala Leu Arg Ala Ser Asn Asn Asp Leu Asn Val Ala Thr Asn 
    290                 295                 300                 


Phe Leu Leu Gln His 
305                 


<210>  6511
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  6511

Met Val Gly Phe Gly Ala Asn Arg Arg Ala Gly Arg Leu Pro Ser Leu 
1               5                   10                  15      


Val Leu Val Val Leu Leu Val Val Ile Val Val Leu Ala Phe Asn Tyr 
            20                  25                  30          


Trp Ser Ile Ser Ser Arg His Val Leu Leu Gln Glu Glu Val Ala Glu 
        35                  40                  45              


Leu Gln Gly Gln Val Gln Arg Thr Glu Val Ala Arg Gly Arg Leu Glu 
    50                  55                  60                  


Lys Arg Asn Ser Asp Leu Leu Leu Leu Val Asp Thr His Lys Lys Gln 
65                  70                  75                  80  


Ile Asp Gln Lys Glu Ala Asp Tyr Gly Arg Leu Ser Ser Arg Leu Gln 
                85                  90                  95      


Ala Arg Glu Gly Leu Gly Lys Arg Cys Glu Asp Asp Lys Val Lys Leu 
            100                 105                 110         


Gln Asn Asn Ile Ser Tyr Gln Met Ala Asp Ile His His Leu Lys Glu 
        115                 120                 125             


Gln Leu Ala Glu Leu Arg Gln Glu Phe Leu Arg Gln Glu Asp Gln Leu 
    130                 135                 140                 


Gln Asp Tyr Arg Lys Asn Asn Thr Tyr Leu Val Lys Arg Leu Glu Tyr 
145                 150                 155                 160 


Glu Ser Phe Gln Cys Gly Gln Gln Met Lys Glu Leu Arg Ala Gln His 
                165                 170                 175     


Glu Glu Asn Ile Lys Lys Leu Ala Asp Gln Phe Leu Glu Glu Gln Lys 
            180                 185                 190         


Gln Glu Thr Gln Lys Ile Gln Ser Asn Asp Gly Lys Glu Leu Asp Ile 
        195                 200                 205             


Asn Asn Gln Val Val Pro Lys Asn Ile Pro Lys Val Ala Glu Asn Val 
    210                 215                 220                 


Ala Asp Lys Asn Glu Glu Pro Ser Ser Asn His Ile Pro His Gly Lys 
225                 230                 235                 240 


Glu Gln Ile Lys Arg Gly Gly Asp Ala Gly Met Pro Gly Ile Glu Glu 
                245                 250                 255     


Asn Asp Leu Ala Lys Val Asp Asp Leu Pro Pro Ala Leu Arg Lys Pro 
            260                 265                 270         


Pro Ile Ser Val Ser Gln His Glu Ser His Gln Ala Ile Ser His Leu 
        275                 280                 285             


Pro Thr Gly Gln Pro Leu Ser Pro Asn Met Pro Pro Asp Ser His Ile 
    290                 295                 300                 


Asn His Asn Gly Asn Pro Gly Thr Ser Lys Gln Asn Pro Ser Ser Pro 
305                 310                 315                 320 


Leu Gln Arg Leu Ile Pro Gly Ser Asn Leu Asp Ser Glu Pro Arg Ile 
                325                 330                 335     


Gln Thr Asp Ile Leu Lys Gln Ala Thr Lys Asp Arg Val Ser Asp Phe 
            340                 345                 350         


His Lys Leu Lys Gln Asn Asp Glu Glu Arg Glu Leu Gln Met Asp Pro 
        355                 360                 365             


Ala Asp Tyr Gly Lys Gln His Phe Asn Asp Val Leu 
    370                 375                 380 


<210>  6512
<211>  832
<212>  PRT
<213>  Homo sapiens

<400>  6512

Met Ala Met Arg Ser Gly Arg His Pro Ser Leu Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Leu Leu Trp Leu Leu Gln Val Ser Ile Ile Asp Ser Val Gln Gln 
            20                  25                  30          


Glu Thr Asp Asp Leu Thr Lys Gln Thr Lys Glu Lys Ile Tyr Gln Pro 
        35                  40                  45              


Leu Arg Arg Ser Lys Arg Arg Trp Val Ile Thr Thr Leu Glu Leu Glu 
    50                  55                  60                  


Glu Glu Asp Pro Gly Pro Phe Pro Lys Leu Ile Gly Glu Leu Phe Asn 
65                  70                  75                  80  


Asn Met Ser Tyr Asn Met Ser Leu Met Tyr Leu Ile Ser Gly Pro Gly 
                85                  90                  95      


Val Asp Glu Tyr Pro Glu Ile Gly Leu Phe Ser Leu Glu Asp His Glu 
            100                 105                 110         


Asn Gly Arg Ile Tyr Val His Arg Pro Val Asp Arg Glu Met Thr Pro 
        115                 120                 125             


Ser Phe Thr Val Tyr Phe Asp Val Val Glu Arg Ser Thr Gly Lys Ile 
    130                 135                 140                 


Val Asp Thr Ser Leu Ile Phe Asn Ile Arg Ile Ser Asp Val Asn Asp 
145                 150                 155                 160 


His Ala Pro Gln Phe Pro Glu Lys Glu Phe Asn Ile Thr Val Gln Glu 
                165                 170                 175     


Asn Gln Ser Ala Gly Gln Pro Ile Phe Gln Met Leu Ala Val Asp Leu 
            180                 185                 190         


Asp Glu Glu Asn Thr Pro Asn Ser Gln Val Leu Tyr Phe Leu Ile Ser 
        195                 200                 205             


Gln Thr Pro Leu Leu Lys Glu Ser Gly Phe Arg Val Asp Arg Leu Ser 
    210                 215                 220                 


Gly Glu Ile Arg Leu Ser Gly Cys Leu Asp Tyr Glu Thr Ala Pro Gln 
225                 230                 235                 240 


Phe Thr Leu Leu Ile Arg Ala Arg Asp Cys Gly Glu Pro Ser Leu Ser 
                245                 250                 255     


Ser Thr Thr Thr Val His Val Asp Val Gln Glu Gly Asn Asn His Arg 
            260                 265                 270         


Pro Ala Phe Thr Gln Glu Asn Tyr Lys Val Gln Ile Pro Glu Gly Arg 
        275                 280                 285             


Ala Ser Gln Gly Val Leu Arg Leu Leu Val Gln Asp Arg Asp Ser Pro 
    290                 295                 300                 


Phe Thr Ser Ala Trp Arg Ala Lys Phe Asn Ile Leu His Gly Asn Glu 
305                 310                 315                 320 


Glu Gly His Phe Asp Ile Ser Thr Asp Pro Glu Thr Asn Glu Gly Ile 
                325                 330                 335     


Leu Asn Val Ile Lys Pro Leu Asp Tyr Glu Thr Arg Pro Ala Gln Ser 
            340                 345                 350         


Leu Ile Ile Val Val Glu Asn Glu Glu Arg Leu Val Phe Cys Glu Arg 
        355                 360                 365             


Gly Lys Leu Gln Pro Pro Arg Lys Ala Ala Ala Ser Ala Thr Val Ser 
    370                 375                 380                 


Val Gln Val Thr Asp Ala Asn Asp Pro Pro Ala Phe His Pro Gln Ser 
385                 390                 395                 400 


Phe Ile Val Asn Lys Glu Glu Gly Ala Arg Pro Gly Thr Leu Leu Gly 
                405                 410                 415     


Thr Phe Asn Ala Met Asp Pro Asp Ser Gln Ile Arg Tyr Glu Leu Val 
            420                 425                 430         


His Asp Pro Ala Asn Trp Val Ser Val Asp Lys Asn Ser Gly Val Val 
        435                 440                 445             


Ile Thr Val Glu Pro Ile Asp Arg Glu Ser Pro His Val Asn Asn Ser 
    450                 455                 460                 


Phe Tyr Val Ile Ile Ile His Ala Val Asp Asp Gly Phe Pro Pro Gln 
465                 470                 475                 480 


Thr Ala Thr Gly Thr Leu Met Leu Phe Leu Ser Asp Ile Asn Asp Asn 
                485                 490                 495     


Val Pro Thr Leu Arg Pro Arg Ser Arg Tyr Met Glu Val Cys Glu Ser 
            500                 505                 510         


Ala Val His Glu Pro Leu His Ile Glu Ala Glu Asp Pro Asp Leu Glu 
        515                 520                 525             


Pro Phe Ser Asp Pro Phe Thr Phe Glu Leu Asp Asn Thr Trp Gly Asn 
    530                 535                 540                 


Ala Glu Asp Thr Trp Lys Leu Gly Arg Asn Trp Gly Gln Ser Val Glu 
545                 550                 555                 560 


Leu Leu Thr Leu Arg Ser Leu Pro Arg Gly Asn Tyr Leu Val Pro Leu 
                565                 570                 575     


Phe Ile Gly Asp Lys Gln Gly Leu Ser Gln Lys Gln Thr Val His Val 
            580                 585                 590         


Arg Ile Cys Pro Cys Ala Ser Gly Leu Thr Cys Val Glu Leu Ala Asp 
        595                 600                 605             


Ala Glu Val Gly Leu His Val Gly Ala Leu Phe Pro Val Cys Ala Ala 
    610                 615                 620                 


Phe Val Ala Leu Ala Val Ala Leu Leu Phe Leu Leu Arg Cys Tyr Phe 
625                 630                 635                 640 


Val Leu Glu Pro Lys Arg His Gly Cys Ser Val Ser Asn Asp Glu Gly 
                645                 650                 655     


His Gln Thr Leu Val Met Tyr Asn Ala Glu Ser Lys Gly Thr Ser Ala 
            660                 665                 670         


Gln Thr Trp Ser Asp Val Glu Gly Gln Arg Pro Ala Leu Leu Ile Cys 
        675                 680                 685             


Thr Ala Ala Ala Gly Pro Thr Gln Gly Val Lys Asp Leu Glu Glu Val 
    690                 695                 700                 


Pro Pro Ser Ala Ala Ser Gln Ser Ala Gln Ala Arg Cys Ala Leu Gly 
705                 710                 715                 720 


Ser Trp Gly Tyr Gly Lys Pro Phe Glu Pro Arg Ser Val Lys Asn Ile 
                725                 730                 735     


His Ser Thr Pro Ala Tyr Pro Asp Ala Thr Met His Arg Gln Leu Leu 
            740                 745                 750         


Ala Pro Val Glu Gly Arg Met Ala Glu Thr Leu Asn Gln Lys Leu His 
        755                 760                 765             


Val Ala Asn Val Leu Glu Asp Asp Pro Gly Tyr Leu Pro His Val Tyr 
    770                 775                 780                 


Ser Glu Glu Gly Glu Cys Gly Gly Ala Pro Ser Leu Ser Ser Leu Ala 
785                 790                 795                 800 


Ser Leu Glu Gln Glu Leu Gln Pro Asp Leu Leu Asp Ser Leu Gly Ser 
                805                 810                 815     


Lys Ala Thr Pro Phe Glu Glu Ile Tyr Ser Glu Ser Gly Val Pro Ser 
            820                 825                 830         


<210>  6513
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  6513

Met Leu Leu Arg Asp Leu Val Leu Arg Arg Gly Cys Cys Trp Ser Ser 
1               5                   10                  15      


Leu Leu Leu His Cys Ala Leu His Pro Leu Trp Gly Phe Val Gln Val 
            20                  25                  30          


Thr His Gly Glu Pro Gln Lys Ser Cys Ser Lys Val Thr Asp Ser Cys 
        35                  40                  45              


Arg His Val Cys Gln Cys Arg Pro Pro Pro Pro Leu Pro Pro Pro Pro 
    50                  55                  60                  


Pro Pro Pro Pro Pro Pro Arg Leu Leu Ser Ala Pro Ala Pro Asn Ser 
65                  70                  75                  80  


Thr Ser Cys Pro Thr Glu Glu Ser Trp Trp Ser Gly Leu Val Ile Ile 
                85                  90                  95      


Ile Ala Val Cys Cys Ala Ser Leu Val Phe Leu Thr Val Leu Val Ile 
            100                 105                 110         


Ile Cys Tyr Lys Ala Ile Lys Arg Lys Pro Leu Arg Lys Asp Glu Asn 
        115                 120                 125             


Gly Thr Ser Val Ala Glu Tyr Pro Met Ser Ala Ser Gln Ser Asn Lys 
    130                 135                 140                 


Gly Val Asp Val Asn Asn Ala Val Val 
145                 150             


<210>  6514
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  6514

Met Ser Gln His Arg His Gln Arg His Ser Arg Val Ile Ser Ser Ser 
1               5                   10                  15      


Pro Val Asp Thr Thr Ser Val Gly Phe Cys Pro Thr Phe Lys Lys Phe 
            20                  25                  30          


Lys Arg Asn Asp Asp Glu Cys Arg Ala Phe Val Lys Arg Val Ile Met 
        35                  40                  45              


Ser Arg Phe Phe Lys Ile Ile Met Ile Ser Thr Val Thr Ser Asn Ala 
    50                  55                  60                  


Phe Phe Met Ala Leu Trp Thr Ser Tyr Asp Ile Arg Tyr Arg Leu Phe 
65                  70                  75                  80  


Arg Leu Leu Glu Phe Ser Glu Ile Phe Phe Val Ser Ile Cys Thr Ser 
                85                  90                  95      


Glu Leu Ser Met Lys Val Tyr Val Asp Pro Ile Asn Tyr Trp Lys Asn 
            100                 105                 110         


Gly Tyr Asn Leu Leu Asp Val Ile Ile Ile Ile Val Met Phe Leu Pro 
        115                 120                 125             


Tyr Ala Leu Arg Gln Leu Met Gly Lys Gln Phe Thr Tyr Leu Tyr Ile 
    130                 135                 140                 


Ala Asp Gly Met Gln Ser Leu Arg Ile Leu Lys Leu Ile Gly Tyr Ser 
145                 150                 155                 160 


Gln Gly Ile Arg Thr Leu Ile Thr Ala Val Gly Gln Thr Val Tyr Thr 
                165                 170                 175     


Val Ala Ser Val Leu Leu Leu Leu Phe Leu Leu Met Tyr Ile Phe Ala 
            180                 185                 190         


Ile Leu Gly Phe Cys Leu Phe Gly Ser Pro Asp Asn Gly Asp His Asp 
        195                 200                 205             


Asn Trp Gly Asn Leu Ala Ala Ala Phe Phe Thr Leu Phe Ser Leu Ala 
    210                 215                 220                 


Thr Val Asp Gly Trp Thr Asp Leu Gln Lys Gln Leu Asp Asn Arg Glu 
225                 230                 235                 240 


Phe Ala Leu Ser Arg Ala Phe Thr Ile Ile Phe Ile Leu Leu Ala Ser 
                245                 250                 255     


Phe Ile Phe Leu Asn Met Phe Val Gly Val Met Ile Met His Thr Glu 
            260                 265                 270         


Asp Ser Ile Arg Lys Phe Glu Arg Glu Leu Met Leu Glu Gln Gln Glu 
        275                 280                 285             


Met Leu Met Gly Glu Lys Gln Val Ile Leu Gln Arg Gln Gln Glu Glu 
    290                 295                 300                 


Ile Ser Arg Leu Met His Ile Gln Lys Asn Ala Asp Cys Thr Ser Phe 
305                 310                 315                 320 


Ser Glu Leu Val Glu Asn Phe Lys Lys Thr Leu Ser His Thr Asp Pro 
                325                 330                 335     


Met Val Leu Asp Asp Phe Gly Thr Ser Leu Pro Phe Ile Asp Ile Tyr 
            340                 345                 350         


Phe Ser Thr Leu Asp Tyr Gln Asp Thr Thr Val His Lys Leu Gln Glu 
        355                 360                 365             


Leu Tyr Tyr Glu Ile Val His Val Leu Ser Leu Met Leu Glu Asp Leu 
    370                 375                 380                 


Pro Gln Glu Lys Pro Gln Ser Leu Glu Lys Val Asp Glu Lys 
385                 390                 395             


<210>  6515
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  6515

Met Ala Ala Glu Asn Glu Ala Ser Gln Glu Ser Ala Leu Gly Ala Tyr 
1               5                   10                  15      


Ser Pro Val Asp Tyr Met Ser Ile Thr Ser Phe Pro Arg Leu Pro Glu 
            20                  25                  30          


Asp Glu Pro Ala Pro Ala Ala Pro Leu Arg Gly Arg Lys Asp Glu Asp 
        35                  40                  45              


Ala Phe Leu Gly Asp Pro Asp Thr Asp Pro Asp Ser Phe Leu Lys Ser 
    50                  55                  60                  


Ala Arg Leu Gln Arg Leu Pro Ser Ser Ser Ser Glu Met Gly Ser Gln 
65                  70                  75                  80  


Asp Gly Ser Pro Leu Arg Glu Thr Arg Lys Asp Pro Phe Ser Ala Ala 
                85                  90                  95      


Ala Ala Glu Cys Ser Cys Arg Gln Asp Gly Leu Thr Val Ile Val Thr 
            100                 105                 110         


Ala Cys Leu Thr Phe Ala Thr Gly Val Thr Val Ala Leu Val Met Gln 
        115                 120                 125             


Ile Tyr Phe Gly Asp Pro Gln Ile Phe Gln Gln Gly Ala Val Val Thr 
    130                 135                 140                 


Asp Ala Ala Arg Cys Thr Ser Leu Gly Ile Glu Val Leu Ser Lys Gln 
145                 150                 155                 160 


Gly Ser Ser Val Asp Ala Ala Val Ala Ala Ala Leu Cys Leu Gly Ile 
                165                 170                 175     


Val Ala Pro His Ser Ser Gly Leu Gly Gly Gly Gly Val Met Leu Val 
            180                 185                 190         


His Asp Ile Arg Arg Asn Glu Ser His Leu Ile Asp Phe Arg Glu Ser 
        195                 200                 205             


Ala Pro Gly Ala Leu Arg Glu Glu Thr Leu Gln Arg Ser Trp Glu Thr 
    210                 215                 220                 


Lys Pro Gly Leu Leu Val Gly Val Pro Gly Met Val Lys Gly Leu His 
225                 230                 235                 240 


Glu Ala His Gln Leu Tyr Gly Arg Leu Pro Trp Ser Gln Val Leu Ala 
                245                 250                 255     


Phe Ala Ala Ala Val Ala Gln Asp Gly Phe Asn Val Thr His Asp Leu 
            260                 265                 270         


Ala Arg Ala Leu Ala Glu Gln Leu Pro Pro Asn Met Ser Glu Arg Phe 
        275                 280                 285             


Arg Glu Thr Phe Leu Pro Ser Gly Arg Pro Pro Leu Pro Gly Ser Leu 
    290                 295                 300                 


Leu His Arg Pro Asp Leu Ala Glu Val Leu Asp Val Leu Gly Thr Ser 
305                 310                 315                 320 


Gly Pro Ala Ala Phe Tyr Ala Gly Gly Asn Leu Thr Leu Glu Met Val 
                325                 330                 335     


Ala Glu Ala Gln His Ala Gly Gly Val Ile Thr Glu Glu Asp Phe Ser 
            340                 345                 350         


Asn Tyr Ser Ala Leu Val Glu Lys Pro Val Cys Gly Val Tyr Arg Gly 
        355                 360                 365             


His Leu Val Leu Ser Pro Pro Pro Pro His Thr Gly Pro Ala Leu Ile 
    370                 375                 380                 


Ser Ala Leu Asn Ile Leu Glu Gly Phe Asn Leu Thr Ser Leu Val Ser 
385                 390                 395                 400 


Arg Glu Gln Ala Leu His Trp Val Ala Glu Thr Leu Lys Ile Ala Leu 
                405                 410                 415     


Ala Leu Ala Ser Arg Leu Gly Asp Pro Val Tyr Asp Ser Thr Ile Thr 
            420                 425                 430         


Glu Ser Met Asp Asp Met Leu Ser Lys Val Glu Ala Ala Tyr Leu Arg 
        435                 440                 445             


Gly His Ile Asn Asp Ser Gln Ala Ala Pro Ala Pro Leu Leu Pro Val 
    450                 455                 460                 


Tyr Glu Leu Asp Gly Ala Pro Thr Ala Ala Gln Val Leu Ile Met Gly 
465                 470                 475                 480 


Pro Asp Asp Phe Ile Val Ala Met Val Ser Ser Leu Asn Gln Pro Phe 
                485                 490                 495     


Gly Ser Gly Leu Ile Thr Pro Ser Gly Ile Leu Leu Asn Ser Gln Met 
            500                 505                 510         


Leu Asp Phe Ser Trp Pro Asn Arg Thr Ala Asn His Ser Ala Pro Ser 
        515                 520                 525             


Leu Glu Asn Ser Val Gln Pro Gly Lys Arg Pro Leu Ser Phe Leu Leu 
    530                 535                 540                 


Pro Thr Val Val Arg Pro Ala Glu Gly Leu Cys Gly Thr Tyr Leu Ala 
545                 550                 555                 560 


Leu Gly Ala Asn Gly Ala Ala Arg Gly Leu Ser Gly Leu Thr Gln Val 
                565                 570                 575     


Leu Leu Asn Val Leu Thr Leu Asn Arg Asn Leu Ser Asp Ser Leu Ala 
            580                 585                 590         


Arg Gly Arg Leu His Pro Asp Leu Gln Ser Asn Leu Leu Gln Val Asp 
        595                 600                 605             


Ser Glu Phe Thr Glu Glu Glu Ile Glu Phe Leu Glu Ala Arg Gly His 
    610                 615                 620                 


His Val Glu Lys Val Asp Val Leu Ser Trp Val His Gly Ser Arg Arg 
625                 630                 635                 640 


Thr Asn Asn Phe Ile Ile Ala Val Lys Asp Pro Arg Ser Pro Asp Ala 
                645                 650                 655     


Ala Gly Ala Thr Ile Leu 
            660         


<210>  6516
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  6516

Met Glu Phe Ser Trp Leu Glu Thr Arg Trp Ala Arg Pro Phe Tyr Leu 
1               5                   10                  15      


Ala Phe Val Phe Cys Leu Ala Leu Gly Leu Leu Gln Ala Ile Lys Leu 
            20                  25                  30          


Tyr Leu Arg Arg Gln Arg Leu Leu Arg Asp Leu Arg Pro Phe Pro Ala 
        35                  40                  45              


Pro Pro Thr His Trp Phe Leu Gly His Gln Lys Phe Ile Gln Asp Asp 
    50                  55                  60                  


Asn Met Glu Lys Leu Glu Glu Ile Ile Glu Lys Tyr Pro Arg Ala Phe 
65                  70                  75                  80  


Pro Phe Trp Ile Gly Pro Phe Gln Ala Phe Phe Cys Ile Tyr Asp Pro 
                85                  90                  95      


Asp Tyr Ala Lys Thr Leu Leu Ser Arg Thr Asp Pro Lys Ser Gln Tyr 
            100                 105                 110         


Leu Gln Lys Phe Ser Pro Pro Leu Leu Gly Lys Gly Leu Ala Ala Leu 
        115                 120                 125             


Asp Gly Pro Lys Trp Phe Gln His Arg Arg Leu Leu Thr Pro Gly Phe 
    130                 135                 140                 


His Phe Asn Ile Leu Lys Ala Tyr Ile Glu Val Met Ala His Ser Val 
145                 150                 155                 160 


Lys Met Met Leu Asp Lys Trp Glu Lys Ile Cys Ser Thr Gln Asp Thr 
                165                 170                 175     


Ser Val Glu Val Tyr Glu His Ile Asn Ser Met Ser Leu Asp Ile Ile 
            180                 185                 190         


Met Lys Cys Ala Phe Ser Lys Glu Thr Asn Cys Gln Thr Asn Ser Thr 
        195                 200                 205             


His Asp Pro Tyr Ala Lys Ala Ile Phe Glu Leu Ser Lys Ile Ile Phe 
    210                 215                 220                 


His Arg Leu Tyr Ser Leu Leu Tyr His Ser Asp Ile Ile Phe Lys Leu 
225                 230                 235                 240 


Ser Pro Gln Gly Tyr Arg Phe Gln Lys Leu Ser Arg Val Leu Asn Gln 
                245                 250                 255     


Tyr Thr Asp Thr Ile Ile Gln Glu Arg Lys Lys Ser Leu Gln Ala Gly 
            260                 265                 270         


Val Lys Gln Asp Asn Thr Pro Lys Arg Lys Tyr Gln Asp Phe Leu Asp 
        275                 280                 285             


Ile Val Leu Ser Ala Lys Asp Glu Ser Gly Ser Ser Phe Ser Asp Ile 
    290                 295                 300                 


Asp Val His Ser Glu Val Ser Thr Phe Leu Leu Ala Gly His Asp Thr 
305                 310                 315                 320 


Leu Ala Ala Ser Ile Ser Trp Ile Leu Tyr Cys Leu Ala Leu Asn Pro 
                325                 330                 335     


Glu His Gln Glu Arg Cys Arg Glu Glu Val Arg Gly Ile Leu Gly Asp 
            340                 345                 350         


Gly Ser Ser Ile Thr Trp Asp Gln Leu Gly Glu Met Ser Tyr Thr Thr 
        355                 360                 365             


Met Cys Ile Lys Glu Thr Cys Arg Leu Ile Pro Ala Val Pro Ser Ile 
    370                 375                 380                 


Ser Arg Asp Leu Ser Lys Pro Leu Thr Phe Pro Asp Gly Cys Thr Leu 
385                 390                 395                 400 


Pro Ala Gly Ile Thr Val Val Leu Ser Ile Trp Gly Leu His His Asn 
                405                 410                 415     


Pro Ala Val Trp Lys Asn Pro Lys Val Phe Asp Pro Leu Arg Phe Ser 
            420                 425                 430         


Gln Glu Asn Ser Asp Gln Arg His Pro Tyr Ala Tyr Leu Pro Phe Ser 
        435                 440                 445             


Ala Gly Ser Arg Asn Cys Ile Gly Gln Glu Phe Ala Met Ile Glu Leu 
    450                 455                 460                 


Lys Val Thr Ile Ala Leu Ile Leu Leu His Phe Arg Val Thr Pro Asp 
465                 470                 475                 480 


Pro Thr Arg Pro Leu Thr Phe Pro Asn His Phe Ile Leu Lys Pro Lys 
                485                 490                 495     


Asn Gly Met Tyr Leu His Leu Lys Lys Leu Ser Glu Cys 
            500                 505                 


<210>  6517
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  6517

Met Ala Glu Ala Glu Gly Val Pro Thr Thr Pro Gly Pro Ala Ser Gly 
1               5                   10                  15      


Ser Thr Phe Arg Gly Arg Arg Asp Val Ser Gly Ser Trp Glu Arg Asp 
            20                  25                  30          


Gln Gln Val Glu Ala Ala Gln Arg Ala Leu Val Glu Val Leu Gly Pro 
        35                  40                  45              


Tyr Glu Pro Leu Leu Ser Arg Val Gln Ala Ala Leu Val Trp Glu Arg 
    50                  55                  60                  


Pro Ala Arg Ser Ala Leu Trp Cys Leu Gly Leu Asn Ala Ala Phe Trp 
65                  70                  75                  80  


Phe Phe Ala Leu Thr Ser Leu Arg Leu Val Phe Leu Leu Ala Phe Gly 
                85                  90                  95      


Leu Met Ile Ile Val Cys Ile Asp Gln Trp Lys Asn Lys Ile Trp Pro 
            100                 105                 110         


Glu Ile Lys Val Pro Arg Pro Asp Ala Leu Asp Asn Glu Ser Trp Gly 
        115                 120                 125             


Phe Val His Pro Arg Leu Leu Ser Val Pro Glu Leu Cys His His Val 
    130                 135                 140                 


Ala Glu Val Trp Val Ser Gly Thr Ile Phe Ile Arg Asn Val Leu Leu 
145                 150                 155                 160 


Phe Lys Lys Gln Asn Pro Gly Lys Phe Cys Leu Leu Ser Cys Gly Ile 
                165                 170                 175     


Leu Thr Phe Leu Ala Val Leu Gly Arg Tyr Val Pro Gly Leu Leu Leu 
            180                 185                 190         


Ser Tyr Leu Met Leu Val Thr Val Met Met Trp Pro Leu Ala Val Tyr 
        195                 200                 205             


His Arg Leu Trp Asp Arg Ala Tyr Val Arg Leu Lys Pro Ala Leu Gln 
    210                 215                 220                 


Arg Leu Asp Phe Ser Val Arg Gly Tyr Met Met Ser Lys Gln Arg Glu 
225                 230                 235                 240 


Arg Gln Leu Arg Arg Arg Ala Leu His Pro Glu Arg Ala Met Asp Asn 
                245                 250                 255     


His Ser Asp Ser Glu Glu Glu Leu Ala Ala Phe Cys Pro Gln Leu Asp 
            260                 265                 270         


Asp Ser Thr Val Ala Arg Glu Leu Ala Ile Thr Asp Ser Glu His Ser 
        275                 280                 285             


Asp Ala Glu Val Ser Cys Thr Asp Asn Gly Thr Phe Asn Leu Ser Arg 
    290                 295                 300                 


Gly Gln Thr Pro Leu Thr Glu Gly Ser Glu Asp Leu Asp Gly His Ser 
305                 310                 315                 320 


Asp Pro Glu Glu Ser Phe Ala Arg Asp Leu Pro Asp Phe Pro Ser Ile 
                325                 330                 335     


Asn Met Asp Pro Ala Gly Leu Asp Asp Glu Asp Asp Thr Ser Ile Gly 
            340                 345                 350         


Met Pro Ser Leu Met Tyr Arg Ser Pro Pro Gly Ala Glu Glu Pro Gln 
        355                 360                 365             


Ala Pro Pro Ala Ser Arg Asp Glu Ala Ala Leu Pro Glu Leu Leu Leu 
    370                 375                 380                 


Gly Ala Leu Pro Val Gly Ser Asn Leu Thr Ser Asn Leu Ala Ser Leu 
385                 390                 395                 400 


Val Ser Gln Gly Met Ile Gln Leu Ala Leu Ser Gly Ala Ser Gln Pro 
                405                 410                 415     


Gly Pro Ser Gly Ala Pro Ala Gln Arg Ala Thr Arg Gly Phe Leu Arg 
            420                 425                 430         


Ser Pro Ser Ser Asp Leu Asp Thr Asp Ala Glu Gly Asp Asp Phe Glu 
        435                 440                 445             


Leu Leu Asp Gln Ser Glu Leu Ser Gln Leu Asp Pro Ala Ser Ser Arg 
    450                 455                 460                 


Ser His 
465     


<210>  6518
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  6518

Met Gln Val Pro Asn Ser Thr Gly Pro Asp Asn Ala Thr Leu Gln Met 
1               5                   10                  15      


Leu Arg Asn Pro Ala Ile Ala Val Ala Leu Pro Val Val Tyr Ser Leu 
            20                  25                  30          


Val Ala Ala Val Ser Ile Pro Gly Asn Leu Phe Ser Leu Trp Val Leu 
        35                  40                  45              


Cys Arg Arg Met Gly Pro Arg Ser Pro Ser Val Ile Phe Met Ile Asn 
    50                  55                  60                  


Leu Ser Val Thr Asp Leu Met Leu Ala Ser Val Leu Pro Phe Gln Ile 
65                  70                  75                  80  


Tyr Tyr His Cys Asn Arg His His Trp Val Phe Gly Val Leu Leu Cys 
                85                  90                  95      


Asn Val Val Thr Val Ala Phe Tyr Ala Asn Met Tyr Ser Ser Ile Leu 
            100                 105                 110         


Thr Met Thr Cys Ile Ser Val Glu Arg Phe Leu Gly Val Leu Tyr Pro 
        115                 120                 125             


Leu Ser Ser Lys Arg Trp Arg Arg Arg Arg Tyr Ala Val Ala Ala Cys 
    130                 135                 140                 


Ala Gly Thr Trp Leu Leu Leu Leu Thr Ala Leu Ser Pro Leu Ala Arg 
145                 150                 155                 160 


Thr Asp Leu Thr Tyr Pro Val His Ala Leu Gly Ile Ile Thr Cys Phe 
                165                 170                 175     


Asp Val Leu Lys Trp Thr Met Leu Pro Ser Val Ala Met Trp Ala Val 
            180                 185                 190         


Phe Leu Phe Thr Ile Phe Ile Leu Leu Phe Leu Ile Pro Phe Val Ile 
        195                 200                 205             


Thr Val Ala Cys Tyr Thr Ala Thr Ile Leu Lys Leu Leu Arg Thr Glu 
    210                 215                 220                 


Glu Ala His Gly Arg Glu Gln Arg Arg Arg Ala Val Gly Leu Ala Ala 
225                 230                 235                 240 


Val Val Leu Leu Ala Phe Val Thr Cys Phe Ala Pro Asn Asn Phe Val 
                245                 250                 255     


Leu Leu Ala His Ile Val Ser Arg Leu Phe Tyr Gly Lys Ser Tyr Tyr 
            260                 265                 270         


His Val Tyr Lys Leu Thr Leu Cys Leu Ser Cys Leu Asn Asn Cys Leu 
        275                 280                 285             


Asp Pro Phe Val Tyr Tyr Phe Ala Ser Arg Glu Phe Gln Leu Arg Leu 
    290                 295                 300                 


Arg Glu Tyr Leu Gly Cys Arg Arg Val Pro Arg Asp Thr Leu Asp Thr 
305                 310                 315                 320 


Arg Arg Glu Ser Leu Phe Ser Ala Arg Thr Thr Ser Val Arg Ser Glu 
                325                 330                 335     


Ala Gly Ala His Pro Glu Gly Met Glu Gly Ala Thr Arg Pro Gly Leu 
            340                 345                 350         


Gln Arg Gln Glu Ser Val Phe 
        355                 


<210>  6519
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  6519

Met Glu Pro Ser Trp Leu Gln Glu Leu Met Ala His Pro Phe Leu Leu 
1               5                   10                  15      


Leu Ile Leu Leu Cys Met Ser Leu Leu Leu Phe Gln Val Ile Arg Leu 
            20                  25                  30          


Tyr Gln Arg Arg Arg Trp Met Ile Arg Ala Leu His Leu Phe Pro Ala 
        35                  40                  45              


Pro Pro Ala His Trp Phe Tyr Gly His Lys Glu Phe Tyr Pro Val Lys 
    50                  55                  60                  


Glu Phe Glu Val Tyr His Lys Leu Met Glu Lys Tyr Pro Cys Ala Val 
65                  70                  75                  80  


Pro Leu Trp Val Gly Pro Phe Thr Met Phe Phe Ser Val His Asp Pro 
                85                  90                  95      


Asp Tyr Ala Lys Ile Leu Leu Lys Arg Gln Asp Pro Lys Ser Ala Val 
            100                 105                 110         


Ser His Lys Ile Leu Glu Ser Trp Val Gly Arg Gly Leu Val Thr Leu 
        115                 120                 125             


Asp Gly Ser Lys Trp Lys Lys His Arg Gln Ile Val Lys Pro Gly Phe 
    130                 135                 140                 


Asn Ile Ser Ile Leu Lys Ile Phe Ile Thr Met Met Ser Glu Ser Val 
145                 150                 155                 160 


Arg Met Met Leu Asn Lys Trp Glu Glu His Ile Ala Gln Asn Ser Arg 
                165                 170                 175     


Leu Glu Leu Phe Gln His Val Ser Leu Met Thr Leu Asp Ser Ile Met 
            180                 185                 190         


Lys Cys Ala Phe Ser His Gln Gly Ser Ile Gln Leu Asp Ser Thr Leu 
        195                 200                 205             


Asp Ser Tyr Leu Lys Ala Val Phe Asn Leu Ser Lys Ile Ser Asn Gln 
    210                 215                 220                 


Arg Met Asn Asn Phe Leu His His Asn Asp Leu Val Phe Lys Phe Ser 
225                 230                 235                 240 


Ser Gln Gly Gln Ile Phe Ser Lys Phe Asn Gln Glu Leu His Gln Phe 
                245                 250                 255     


Thr Glu Lys Val Ile Gln Asp Arg Lys Glu Ser Leu Lys Asp Lys Leu 
            260                 265                 270         


Lys Gln Asp Thr Thr Gln Lys Arg Arg Trp Asp Phe Leu Asp Ile Leu 
        275                 280                 285             


Leu Ser Ala Lys Ser Glu Asn Thr Lys Asp Phe Ser Glu Ala Asp Leu 
    290                 295                 300                 


Gln Ala Glu Val Lys Thr Phe Met Phe Ala Gly His Asp Thr Thr Ser 
305                 310                 315                 320 


Ser Ala Ile Ser Trp Ile Leu Tyr Cys Leu Ala Lys Tyr Pro Glu His 
                325                 330                 335     


Gln Gln Arg Cys Arg Asp Glu Ile Arg Glu Leu Leu Gly Asp Gly Ser 
            340                 345                 350         


Ser Ile Thr Trp Glu His Leu Ser Gln Met Pro Tyr Thr Thr Met Cys 
        355                 360                 365             


Ile Lys Glu Cys Leu Arg Leu Tyr Ala Pro Val Val Asn Ile Ser Arg 
    370                 375                 380                 


Leu Leu Asp Lys Pro Ile Thr Phe Pro Asp Gly Arg Ser Leu Pro Ala 
385                 390                 395                 400 


Gly Ile Thr Val Phe Ile Asn Ile Trp Ala Leu His His Asn Pro Tyr 
                405                 410                 415     


Phe Trp Glu Asp Pro Gln Val Phe Asn Pro Leu Arg Phe Ser Arg Glu 
            420                 425                 430         


Asn Ser Glu Lys Ile His Pro Tyr Ala Phe Ile Pro Phe Ser Ala Gly 
        435                 440                 445             


Leu Arg Asn Cys Ile Gly Gln His Phe Ala Ile Ile Glu Cys Lys Val 
    450                 455                 460                 


Ala Val Ala Leu Thr Leu Leu Arg Phe Lys Leu Ala Pro Asp His Ser 
465                 470                 475                 480 


Arg Pro Pro Gln Pro Val Arg Gln Val Val Leu Lys Ser Lys Asn Gly 
                485                 490                 495     


Ile His Val Phe Ala Lys Lys Val Cys 
            500                 505 


<210>  6520
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  6520

Met Asp Ala Arg Trp Trp Ala Val Val Val Leu Ala Ala Phe Pro Ser 
1               5                   10                  15      


Leu Gly Ala Gly Gly Glu Thr Pro Glu Ala Pro Pro Glu Ser Trp Thr 
            20                  25                  30          


Gln Leu Trp Phe Phe Arg Phe Val Val Asn Ala Ala Gly Tyr Ala Ser 
        35                  40                  45              


Phe Met Val Pro Gly Tyr Leu Leu Val Gln Tyr Phe Arg Arg Lys Asn 
    50                  55                  60                  


Tyr Leu Glu Thr Gly Arg Gly Leu Cys Phe Pro Leu Val Lys Ala Cys 
65                  70                  75                  80  


Val Phe Gly Asn Glu Pro Lys Ala Ser Asp Glu Val Pro Leu Ala Pro 
                85                  90                  95      


Arg Thr Glu Ala Ala Glu Thr Thr Pro Met Trp Gln Ala Leu Lys Leu 
            100                 105                 110         


Leu Phe Cys Ala Thr Gly Leu Gln Val Ser Tyr Leu Thr Trp Gly Val 
        115                 120                 125             


Leu Gln Glu Arg Val Met Thr Arg Ser Tyr Gly Ala Thr Ala Thr Ser 
    130                 135                 140                 


Pro Gly Glu Arg Phe Thr Asp Ser Gln Phe Leu Val Leu Met Asn Arg 
145                 150                 155                 160 


Val Leu Ala Leu Ile Val Ala Gly Leu Ser Cys Val Leu Cys Lys Gln 
                165                 170                 175     


Pro Arg His Gly Ala Pro Met Tyr Arg Tyr Ser Phe Ala Ser Leu Ser 
            180                 185                 190         


Asn Val Leu Ser Ser Trp Cys Gln Tyr Glu Ala Leu Lys Phe Val Ser 
        195                 200                 205             


Phe Pro Thr Gln Val Leu Ala Lys Ala Ser Lys Val Ile Pro Val Met 
    210                 215                 220                 


Leu Met Gly Lys Leu Val Ser Arg Arg Ser Tyr Glu His Trp Glu Tyr 
225                 230                 235                 240 


Leu Thr Ala Thr Leu Ile Ser Ile Gly Val Ser Met Phe Leu Leu Ser 
                245                 250                 255     


Ser Gly Pro Glu Pro Arg Ser Ser Pro Ala Thr Thr Leu Ser Gly Leu 
            260                 265                 270         


Ile Leu Leu Ala Gly Tyr Ile Ala Phe Asp Ser Phe Thr Ser Asn Trp 
        275                 280                 285             


Gln Asp Ala Leu Phe Ala Tyr Lys Met Ser Ser Val Gln Met Met Phe 
    290                 295                 300                 


Gly Val Asn Phe Phe Ser Cys Leu Phe Thr Val Gly Ser Leu Leu Glu 
305                 310                 315                 320 


Gln Gly Ala Leu Leu Glu Gly Thr Arg Phe Met Gly Arg His Ser Glu 
                325                 330                 335     


Phe Ala Ala His Ala Leu Leu Leu Ser Ile Cys Ser Ala Cys Gly Gln 
            340                 345                 350         


Leu Phe Ile Phe Tyr Thr Ile Gly Gln Phe Gly Ala Ala Val Phe Thr 
        355                 360                 365             


Ile Ile Met Thr Leu Arg Gln Ala Phe Ala Ile Leu Leu Ser Cys Leu 
    370                 375                 380                 


Leu Tyr Gly His Thr Val Thr Val Val Gly Gly Leu Gly Val Ala Val 
385                 390                 395                 400 


Val Phe Ala Ala Leu Leu Leu Arg Val Tyr Ala Arg Gly Arg Leu Lys 
                405                 410                 415     


Gln Arg Gly Lys Lys Ala Val Pro Val Glu Ser Pro Val Gln Lys Val 
            420                 425                 430         


<210>  6521
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  6521

Met Arg Pro Trp Thr Gly Ser Trp Arg Trp Ile Met Leu Ile Leu Phe 
1               5                   10                  15      


Ala Trp Gly Thr Leu Leu Phe Tyr Ile Gly Gly His Leu Val Arg Asp 
            20                  25                  30          


Asn Asp His Pro Asp His Ser Ser Arg Glu Leu Ser Lys Ile Leu Ala 
        35                  40                  45              


Lys Leu Glu Arg Leu Lys Gln Gln Asn Glu Asp Leu Arg Arg Met Ala 
    50                  55                  60                  


Glu Ser Leu Arg Ile Pro Glu Gly Pro Ile Asp Gln Gly Pro Ala Ile 
65                  70                  75                  80  


Gly Arg Val Arg Val Leu Glu Glu Gln Leu Val Lys Ala Lys Glu Gln 
                85                  90                  95      


Ile Glu Asn Tyr Lys Lys Gln Thr Arg Asn Gly Leu Gly Lys Asp His 
            100                 105                 110         


Glu Ile Leu Arg Arg Arg Ile Glu Asn Gly Ala Lys Glu Leu Trp Phe 
        115                 120                 125             


Phe Leu Gln Ser Glu Leu Lys Lys Leu Lys Asn Leu Glu Gly Asn Glu 
    130                 135                 140                 


Leu Gln Arg His Ala Asp Glu Phe Leu Leu Asp Leu Gly His His Glu 
145                 150                 155                 160 


Arg Ser Ile Met Thr Asp Leu Tyr Tyr Leu Ser Gln Thr Asp Gly Ala 
                165                 170                 175     


Gly Asp Trp Arg Glu Lys Glu Ala Lys Asp Leu Thr Glu Leu Val Gln 
            180                 185                 190         


Arg Arg Ile Thr Tyr Leu Gln Asn Pro Lys Asp Cys Ser Lys Ala Lys 
        195                 200                 205             


Lys Leu Val Cys Asn Ile Asn Lys Gly Cys Gly Tyr Gly Cys Gln Leu 
    210                 215                 220                 


His His Val Val Tyr Cys Phe Met Ile Ala Tyr Gly Thr Gln Arg Thr 
225                 230                 235                 240 


Leu Ile Leu Glu Ser Gln Asn Trp Arg Tyr Ala Thr Gly Gly Trp Glu 
                245                 250                 255     


Thr Val Phe Arg Pro Val Ser Glu Thr Cys Thr Asp Arg Ser Gly Ile 
            260                 265                 270         


Ser Thr Gly His Trp Ser Gly Glu Val Lys Asp Lys Asn Val Gln Val 
        275                 280                 285             


Val Glu Leu Pro Ile Val Asp Ser Leu His Pro Arg Pro Pro Tyr Leu 
    290                 295                 300                 


Pro Leu Ala Val Pro Glu Asp Leu Ala Asp Arg Leu Val Arg Val His 
305                 310                 315                 320 


Gly Asp Pro Ala Val Trp Trp Val Ser Gln Phe Val Lys Tyr Leu Ile 
                325                 330                 335     


Arg Pro Gln Pro Trp Leu Glu Lys Glu Ile Glu Glu Ala Thr Lys Lys 
            340                 345                 350         


Leu Gly Phe Lys His Pro Val Ile Gly Val His Val Arg Arg Thr Asp 
        355                 360                 365             


Lys Val Gly Thr Glu Ala Ala Phe His Pro Ile Glu Glu Tyr Met Val 
    370                 375                 380                 


His Val Glu Glu His Phe Gln Leu Leu Ala Arg Arg Met Gln Val Asp 
385                 390                 395                 400 


Lys Lys Arg Val Tyr Leu Ala Thr Asp Asp Pro Ser Leu Leu Lys Glu 
                405                 410                 415     


Ala Lys Thr Lys Tyr Pro Asn Tyr Glu Phe Ile Ser Asp Asn Ser Ile 
            420                 425                 430         


Ser Trp Ser Ala Gly Leu His Asn Arg Tyr Thr Glu Asn Ser Leu Arg 
        435                 440                 445             


Gly Val Ile Leu Asp Ile His Phe Leu Ser Gln Ala Asp Phe Leu Val 
    450                 455                 460                 


Cys Thr Phe Ser Ser Gln Val Cys Arg Val Ala Tyr Glu Ile Met Gln 
465                 470                 475                 480 


Thr Leu His Pro Asp Ala Ser Ala Asn Phe His Ser Leu Asp Asp Ile 
                485                 490                 495     


Tyr Tyr Phe Gly Gly Gln Asn Ala His Asn Gln Ile Ala Ile Tyr Ala 
            500                 505                 510         


His Gln Pro Arg Thr Ala Asp Glu Ile Pro Met Glu Pro Gly Asp Ile 
        515                 520                 525             


Ile Gly Val Ala Gly Asn His Trp Asp Gly Tyr Ser Lys Gly Val Asn 
    530                 535                 540                 


Arg Lys Leu Gly Arg Thr Gly Leu Tyr Pro Ser Tyr Lys Val Arg Glu 
545                 550                 555                 560 


Lys Ile Glu Thr Val Lys Tyr Pro Thr Tyr Pro Glu Ala Glu Lys 
                565                 570                 575 


<210>  6522
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  6522

Met Arg Pro Trp Thr Gly Ser Trp Arg Trp Ile Met Leu Ile Leu Phe 
1               5                   10                  15      


Ala Trp Gly Thr Leu Leu Phe Tyr Ile Gly Gly His Leu Val Arg Asp 
            20                  25                  30          


Asn Asp His Pro Asp His Ser Ser Arg Glu Leu Ser Lys Ile Leu Ala 
        35                  40                  45              


Lys Leu Glu Arg Leu Lys Gln Gln Asn Glu Asp Leu Arg Arg Met Ala 
    50                  55                  60                  


Glu Ser Leu Arg Ile Pro Glu Gly Pro Ile Asp Gln Gly Pro Ala Ile 
65                  70                  75                  80  


Gly Arg Val Arg Val Leu Glu Glu Gln Leu Val Lys Ala Lys Glu Gln 
                85                  90                  95      


Ile Glu Asn Tyr Lys Lys Gln Thr Arg Asn Gly Leu Gly Lys Asp His 
            100                 105                 110         


Glu Ile Leu Arg Arg Arg Ile Glu Asn Gly Ala Lys Glu Leu Trp Phe 
        115                 120                 125             


Phe Leu Gln Ser Glu Leu Lys Lys Leu Lys Asn Leu Glu Gly Asn Glu 
    130                 135                 140                 


Leu Gln Arg His Ala Asp Glu Phe Leu Leu Asp Leu Gly His His Glu 
145                 150                 155                 160 


Arg Ser Ile Met Thr Asp Leu Tyr Tyr Leu Ser Gln Thr Asp Gly Ala 
                165                 170                 175     


Gly Asp Trp Arg Glu Lys Glu Ala Lys Asp Leu Thr Glu Leu Val Gln 
            180                 185                 190         


Arg Arg Ile Thr Tyr Leu Gln Asn Pro Lys Asp Cys Ser Lys Ala Lys 
        195                 200                 205             


Lys Leu Val Cys Asn Ile Asn Lys Gly Cys Gly Tyr Gly Cys Gln Leu 
    210                 215                 220                 


His His Val Val Tyr Cys Phe Met Ile Ala Tyr Gly Thr Gln Arg Thr 
225                 230                 235                 240 


Leu Ile Leu Glu Ser Gln Asn Trp Arg Tyr Ala Thr Gly Gly Trp Glu 
                245                 250                 255     


Thr Val Phe Arg Pro Val Ser Glu Thr Cys Thr Asp Arg Ser Gly Ile 
            260                 265                 270         


Ser Thr Gly His Trp Ser Gly Glu Val Lys Asp Lys Asn Val Gln Val 
        275                 280                 285             


Val Glu Leu Pro Ile Val Asp Ser Leu His Pro Arg Pro Pro Tyr Leu 
    290                 295                 300                 


Pro Leu Ala Val Pro Glu Asp Leu Ala Asp Arg Leu Val Arg Val His 
305                 310                 315                 320 


Gly Asp Pro Ala Val Trp Trp Val Ser Gln Phe Val Lys Tyr Leu Ile 
                325                 330                 335     


Arg Pro Gln Pro Trp Leu Glu Lys Glu Ile Glu Glu Ala Thr Lys Lys 
            340                 345                 350         


Leu Gly Phe Lys His Pro Val Ile Gly Val His Val Arg Arg Thr Asp 
        355                 360                 365             


Lys Val Gly Thr Glu Ala Ala Phe His Pro Ile Glu Glu Tyr Met Val 
    370                 375                 380                 


His Val Glu Glu His Phe Gln Leu Leu Ala Arg Arg Met Gln Val Asp 
385                 390                 395                 400 


Lys Lys Arg Val Tyr Leu Ala Thr Asp Asp Pro Ser Leu Leu Lys Glu 
                405                 410                 415     


Ala Lys Thr Lys Tyr Pro Asn Tyr Glu Phe Ile Ser Asp Asn Ser Ile 
            420                 425                 430         


Ser Trp Ser Ala Gly Leu His Asn Arg Tyr Thr Glu Asn Ser Leu Arg 
        435                 440                 445             


Gly Val Ile Leu Asp Ile His Phe Leu Ser Gln Ala Asp Phe Leu Val 
    450                 455                 460                 


Cys Thr Phe Ser Ser Gln Val Cys Arg Val Ala Tyr Glu Ile Met Gln 
465                 470                 475                 480 


Thr Leu His Pro Asp Ala Ser Ala Asn Phe His Ser Leu Asp Asp Ile 
                485                 490                 495     


Tyr Tyr Phe Gly Gly Gln Asn Ala His Asn Gln Ile Ala Ile Tyr Ala 
            500                 505                 510         


His Gln Pro Arg Thr Ala Asp Glu Ile Pro Met Glu Pro Gly Asp Ile 
        515                 520                 525             


Ile Gly Val Ala Gly Asn His Trp Asp Gly Tyr Ser Lys Gly Val Asn 
    530                 535                 540                 


Arg Lys Leu Gly Arg Thr Gly Leu Tyr Pro Ser Tyr Lys Val Arg Glu 
545                 550                 555                 560 


Lys Ile Glu Thr Val Lys Tyr Pro Thr Tyr Pro Glu Ala Glu Lys 
                565                 570                 575 


<210>  6523
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  6523

Met Arg Pro Trp Thr Gly Ser Trp Arg Trp Ile Met Leu Ile Leu Phe 
1               5                   10                  15      


Ala Trp Gly Thr Leu Leu Phe Tyr Ile Gly Gly His Leu Val Arg Asp 
            20                  25                  30          


Asn Asp His Pro Asp His Ser Ser Arg Glu Leu Ser Lys Ile Leu Ala 
        35                  40                  45              


Lys Leu Glu Arg Leu Lys Gln Gln Asn Glu Asp Leu Arg Arg Met Ala 
    50                  55                  60                  


Glu Ser Leu Arg Ile Pro Glu Gly Pro Ile Asp Gln Gly Pro Ala Ile 
65                  70                  75                  80  


Gly Arg Val Arg Val Leu Glu Glu Gln Leu Val Lys Ala Lys Glu Gln 
                85                  90                  95      


Ile Glu Asn Tyr Lys Lys Gln Thr Arg Asn Gly Leu Gly Lys Asp His 
            100                 105                 110         


Glu Ile Leu Arg Arg Arg Ile Glu Asn Gly Ala Lys Glu Leu Trp Phe 
        115                 120                 125             


Phe Leu Gln Ser Glu Leu Lys Lys Leu Lys Asn Leu Glu Gly Asn Glu 
    130                 135                 140                 


Leu Gln Arg His Ala Asp Glu Phe Leu Leu Asp Leu Gly His His Glu 
145                 150                 155                 160 


Arg Ser Ile Met Thr Asp Leu Tyr Tyr Leu Ser Gln Thr Asp Gly Ala 
                165                 170                 175     


Gly Asp Trp Arg Glu Lys Glu Ala Lys Asp Leu Thr Glu Leu Val Gln 
            180                 185                 190         


Arg Arg Ile Thr Tyr Leu Gln Asn Pro Lys Asp Cys Ser Lys Ala Lys 
        195                 200                 205             


Lys Leu Val Cys Asn Ile Asn Lys Gly Cys Gly Tyr Gly Cys Gln Leu 
    210                 215                 220                 


His His Val Val Tyr Cys Phe Met Ile Ala Tyr Gly Thr Gln Arg Thr 
225                 230                 235                 240 


Leu Ile Leu Glu Ser Gln Asn Trp Arg Tyr Ala Thr Gly Gly Trp Glu 
                245                 250                 255     


Thr Val Phe Arg Pro Val Ser Glu Thr Cys Thr Asp Arg Ser Gly Ile 
            260                 265                 270         


Ser Thr Gly His Trp Ser Gly Glu Val Lys Asp Lys Asn Val Gln Val 
        275                 280                 285             


Val Glu Leu Pro Ile Val Asp Ser Leu His Pro Arg Pro Pro Tyr Leu 
    290                 295                 300                 


Pro Leu Ala Val Pro Glu Asp Leu Ala Asp Arg Leu Val Arg Val His 
305                 310                 315                 320 


Gly Asp Pro Ala Val Trp Trp Val Ser Gln Phe Val Lys Tyr Leu Ile 
                325                 330                 335     


Arg Pro Gln Pro Trp Leu Glu Lys Glu Ile Glu Glu Ala Thr Lys Lys 
            340                 345                 350         


Leu Gly Phe Lys His Pro Val Ile Gly Val His Val Arg Arg Thr Asp 
        355                 360                 365             


Lys Val Gly Thr Glu Ala Ala Phe His Pro Ile Glu Glu Tyr Met Val 
    370                 375                 380                 


His Val Glu Glu His Phe Gln Leu Leu Ala Arg Arg Met Gln Val Asp 
385                 390                 395                 400 


Lys Lys Arg Val Tyr Leu Ala Thr Asp Asp Pro Ser Leu Leu Lys Glu 
                405                 410                 415     


Ala Lys Thr Lys Tyr Pro Asn Tyr Glu Phe Ile Ser Asp Asn Ser Ile 
            420                 425                 430         


Ser Trp Ser Ala Gly Leu His Asn Arg Tyr Thr Glu Asn Ser Leu Arg 
        435                 440                 445             


Gly Val Ile Leu Asp Ile His Phe Leu Ser Gln Ala Asp Phe Leu Val 
    450                 455                 460                 


Cys Thr Phe Ser Ser Gln Val Cys Arg Val Ala Tyr Glu Ile Met Gln 
465                 470                 475                 480 


Thr Leu His Pro Asp Ala Ser Ala Asn Phe His Ser Leu Asp Asp Ile 
                485                 490                 495     


Tyr Tyr Phe Gly Gly Gln Asn Ala His Asn Gln Ile Ala Ile Tyr Ala 
            500                 505                 510         


His Gln Pro Arg Thr Ala Asp Glu Ile Pro Met Glu Pro Gly Asp Ile 
        515                 520                 525             


Ile Gly Val Ala Gly Asn His Trp Asp Gly Tyr Ser Lys Gly Val Asn 
    530                 535                 540                 


Arg Lys Leu Gly Arg Thr Gly Leu Tyr Pro Ser Tyr Lys Val Arg Glu 
545                 550                 555                 560 


Lys Ile Glu Thr Val Lys Tyr Pro Thr Tyr Pro Glu Ala Glu Lys 
                565                 570                 575 


<210>  6524
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  6524

Met Arg Pro Trp Thr Gly Ser Trp Arg Trp Ile Met Leu Ile Leu Phe 
1               5                   10                  15      


Ala Trp Gly Thr Leu Leu Phe Tyr Ile Gly Gly His Leu Val Arg Asp 
            20                  25                  30          


Asn Asp His Pro Asp His Ser Ser Arg Glu Leu Ser Lys Ile Leu Ala 
        35                  40                  45              


Lys Leu Glu Arg Leu Lys Gln Gln Asn Glu Asp Leu Arg Arg Met Ala 
    50                  55                  60                  


Glu Ser Leu Arg Ile Pro Glu Gly Pro Ile Asp Gln Gly Pro Ala Ile 
65                  70                  75                  80  


Gly Arg Val Arg Val Leu Glu Glu Gln Leu Val Lys Ala Lys Glu Gln 
                85                  90                  95      


Ile Glu Asn Tyr Lys Lys Gln Thr Arg Asn Gly Leu Gly Lys Asp His 
            100                 105                 110         


Glu Ile Leu Arg Arg Arg Ile Glu Asn Gly Ala Lys Glu Leu Trp Phe 
        115                 120                 125             


Phe Leu Gln Ser Glu Leu Lys Lys Leu Lys Asn Leu Glu Gly Asn Glu 
    130                 135                 140                 


Leu Gln Arg His Ala Asp Glu Phe Leu Leu Asp Leu Gly His His Glu 
145                 150                 155                 160 


Arg Ser Ile Met Thr Asp Leu Tyr Tyr Leu Ser Gln Thr Asp Gly Ala 
                165                 170                 175     


Gly Asp Trp Arg Glu Lys Glu Ala Lys Asp Leu Thr Glu Leu Val Gln 
            180                 185                 190         


Arg Arg Ile Thr Tyr Leu Gln Asn Pro Lys Asp Cys Ser Lys Ala Lys 
        195                 200                 205             


Lys Leu Val Cys Asn Ile Asn Lys Gly Cys Gly Tyr Gly Cys Gln Leu 
    210                 215                 220                 


His His Val Val Tyr Cys Phe Met Ile Ala Tyr Gly Thr Gln Arg Thr 
225                 230                 235                 240 


Leu Ile Leu Glu Ser Gln Asn Trp Arg Tyr Ala Thr Gly Gly Trp Glu 
                245                 250                 255     


Thr Val Phe Arg Pro Val Ser Glu Thr Cys Thr Asp Arg Ser Gly Ile 
            260                 265                 270         


Ser Thr Gly His Trp Ser Gly Glu Val Lys Asp Lys Asn Val Gln Val 
        275                 280                 285             


Val Glu Leu Pro Ile Val Asp Ser Leu His Pro Arg Pro Pro Tyr Leu 
    290                 295                 300                 


Pro Leu Ala Val Pro Glu Asp Leu Ala Asp Arg Leu Val Arg Val His 
305                 310                 315                 320 


Gly Asp Pro Ala Val Trp Trp Val Ser Gln Phe Val Lys Tyr Leu Ile 
                325                 330                 335     


Arg Pro Gln Pro Trp Leu Glu Lys Glu Ile Glu Glu Ala Thr Lys Lys 
            340                 345                 350         


Leu Gly Phe Lys His Pro Val Ile Gly Val His Val Arg Arg Thr Asp 
        355                 360                 365             


Lys Val Gly Thr Glu Ala Ala Phe His Pro Ile Glu Glu Tyr Met Val 
    370                 375                 380                 


His Val Glu Glu His Phe Gln Leu Leu Ala Arg Arg Met Gln Val Asp 
385                 390                 395                 400 


Lys Lys Arg Val Tyr Leu Ala Thr Asp Asp Pro Ser Leu Leu Lys Glu 
                405                 410                 415     


Ala Lys Thr Lys Tyr Pro Asn Tyr Glu Phe Ile Ser Asp Asn Ser Ile 
            420                 425                 430         


Ser Trp Ser Ala Gly Leu His Asn Arg Tyr Thr Glu Asn Ser Leu Arg 
        435                 440                 445             


Gly Val Ile Leu Asp Ile His Phe Leu Ser Gln Ala Asp Phe Leu Val 
    450                 455                 460                 


Cys Thr Phe Ser Ser Gln Val Cys Arg Val Ala Tyr Glu Ile Met Gln 
465                 470                 475                 480 


Thr Leu His Pro Asp Ala Ser Ala Asn Phe His Ser Leu Asp Asp Ile 
                485                 490                 495     


Tyr Tyr Phe Gly Gly Gln Asn Ala His Asn Gln Ile Ala Ile Tyr Ala 
            500                 505                 510         


His Gln Pro Arg Thr Ala Asp Glu Ile Pro Met Glu Pro Gly Asp Ile 
        515                 520                 525             


Ile Gly Val Ala Gly Asn His Trp Asp Gly Tyr Ser Lys Gly Val Asn 
    530                 535                 540                 


Arg Lys Leu Gly Arg Thr Gly Leu Tyr Pro Ser Tyr Lys Val Arg Glu 
545                 550                 555                 560 


Lys Ile Glu Thr Val Lys Tyr Pro Thr Tyr Pro Glu Ala Glu Lys 
                565                 570                 575 


<210>  6525
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  6525

Met Ala Ile Gly Asn Trp Thr Glu Ile Ser Glu Phe Ile Leu Met Ser 
1               5                   10                  15      


Phe Ser Ser Leu Pro Thr Glu Ile Gln Ser Leu Leu Phe Leu Thr Phe 
            20                  25                  30          


Leu Thr Ile Tyr Leu Val Thr Leu Lys Gly Asn Ser Leu Ile Ile Leu 
        35                  40                  45              


Val Thr Leu Ala Asp Pro Met Leu His Ser Pro Met Tyr Phe Phe Leu 
    50                  55                  60                  


Arg Asn Leu Ser Phe Leu Glu Ile Gly Phe Asn Leu Val Ile Val Pro 
65                  70                  75                  80  


Lys Met Leu Gly Thr Leu Leu Ala Gln Asp Thr Thr Ile Ser Phe Leu 
                85                  90                  95      


Gly Cys Ala Thr Gln Met Tyr Phe Phe Phe Phe Phe Gly Val Ala Glu 
            100                 105                 110         


Cys Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 
        115                 120                 125             


Ser Pro Leu His Tyr Pro Val Ile Met Asn Gln Arg Thr Arg Ala Lys 
    130                 135                 140                 


Leu Ala Ala Ala Ser Trp Phe Pro Gly Phe Pro Val Ala Thr Val Gln 
145                 150                 155                 160 


Thr Thr Trp Leu Phe Ser Phe Pro Phe Cys Gly Thr Asn Lys Val Asn 
                165                 170                 175     


His Phe Phe Cys Asp Ser Pro Pro Val Leu Lys Leu Val Cys Ala Asp 
            180                 185                 190         


Thr Ala Leu Phe Glu Ile Tyr Ala Ile Val Gly Thr Ile Leu Val Val 
        195                 200                 205             


Met Ile Pro Cys Leu Leu Ile Leu Cys Ser Tyr Thr Arg Ile Ala Ala 
    210                 215                 220                 


Ala Ile Leu Lys Ile Pro Ser Ala Lys Gly Lys His Lys Ala Phe Ser 
225                 230                 235                 240 


Thr Cys Ser Ser His Leu Leu Val Val Ser Leu Phe Tyr Ile Ser Ser 
                245                 250                 255     


Ser Leu Thr Tyr Phe Trp Pro Lys Ser Asn Asn Ser Pro Glu Ser Lys 
            260                 265                 270         


Lys Leu Leu Ser Leu Ser Tyr Thr Val Val Thr Pro Met Leu Asn Pro 
        275                 280                 285             


Ile Ile Tyr Ser Leu Arg Asn Ser Glu Val Lys Asn Ala Leu Ser Arg 
    290                 295                 300                 


Thr Phe His Lys Val Leu Ala Leu Arg Asn Cys Ile Pro 
305                 310                 315         


<210>  6526
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  6526

Met Gly Leu Thr Leu Leu Leu Leu Leu Leu Leu Gly Leu Glu Gly Gln 
1               5                   10                  15      


Gly Ile Val Gly Ser Leu Pro Glu Val Leu Gln Ala Pro Val Gly Ser 
            20                  25                  30          


Ser Ile Leu Val Gln Cys His Tyr Arg Leu Gln Asp Val Lys Ala Gln 
        35                  40                  45              


Lys Val Trp Cys Arg Phe Leu Pro Glu Gly Cys Gln Pro Leu Val Ser 
    50                  55                  60                  


Ser Ala Val Asp Arg Arg Ala Pro Ala Gly Arg Arg Thr Phe Leu Thr 
65                  70                  75                  80  


Asp Leu Gly Gly Gly Leu Leu Gln Val Glu Met Val Thr Leu Gln Glu 
                85                  90                  95      


Glu Asp Ala Gly Glu Tyr Gly Cys Met Val Asp Gly Ala Arg Gly Pro 
            100                 105                 110         


Gln Ile Leu His Arg Val Ser Leu Asn Ile Leu Pro Pro Glu Glu Glu 
        115                 120                 125             


Glu Glu Thr His Lys Ile Gly Ser Leu Ala Glu Asn Ala Phe Ser Asp 
    130                 135                 140                 


Pro Ala Gly Ser Ala Asn Pro Leu Glu Pro Ser Gln Asp Glu Lys Ser 
145                 150                 155                 160 


Ile Pro Leu Ile Trp Gly Ala Val Leu Leu Val Gly Leu Leu Val Ala 
                165                 170                 175     


Ala Val Val Leu Phe Ala Val Met Ala Lys Arg Lys Gln Gly Asn Arg 
            180                 185                 190         


Leu Gly Val Cys Gly Arg Phe Leu Ser Ser Arg Val Ser Gly Met Asn 
        195                 200                 205             


Pro Ser Ser Val Val His His Val Ser Asp Ser Gly Pro Ala Ala Glu 
    210                 215                 220                 


Leu Pro Leu Asp Val Pro His Ile Arg Leu Asp Ser Pro Pro Ser Phe 
225                 230                 235                 240 


Asp Asn Thr Thr Tyr Thr Ser Leu Pro Leu Asp Ser Pro Ser Gly Lys 
                245                 250                 255     


Pro Ser Leu Pro Ala Pro Ser Ser Leu Pro Pro Leu Pro Pro Lys Val 
            260                 265                 270         


Leu Val Cys Ser Lys Pro Val Thr Tyr Ala Thr Val Ile Phe Pro Gly 
        275                 280                 285             


Gly Asn Lys Gly Gly Gly Thr Ser Cys Gly Pro Ala Gln Asn Pro Pro 
    290                 295                 300                 


Asn Asn Gln Thr Pro Ser Ser 
305                 310     


<210>  6527
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  6527

Met Arg Ser Ser Leu Thr Met Val Gly Thr Leu Trp Ala Phe Leu Ser 
1               5                   10                  15      


Leu Val Thr Ala Val Thr Ser Ser Thr Ser Tyr Phe Leu Pro Tyr Trp 
            20                  25                  30          


Leu Phe Gly Ser Gln Met Gly Lys Pro Val Ser Phe Ser Thr Phe Arg 
        35                  40                  45              


Arg Cys Asn Tyr Pro Val Arg Gly Glu Gly His Ser Leu Ile Met Val 
    50                  55                  60                  


Glu Glu Cys Gly Arg Tyr Ala Ser Phe Asn Ala Ile Pro Ser Leu Ala 
65                  70                  75                  80  


Trp Gln Met Cys Thr Val Val Thr Gly Ala Gly Cys Ala Leu Leu Leu 
                85                  90                  95      


Leu Val Ala Leu Ala Ala Val Leu Gly Cys Cys Met Glu Glu Leu Ile 
            100                 105                 110         


Ser Arg Met Met Gly Arg Cys Met Gly Ala Ala Gln Phe Val Gly Gly 
        115                 120                 125             


Leu Leu Ile Ser Ser Gly Cys Ala Leu Tyr Pro Leu Gly Trp Asn Ser 
    130                 135                 140                 


Pro Glu Ile Met Gln Thr Cys Gly Asn Val Ser Asn Gln Phe Gln Leu 
145                 150                 155                 160 


Gly Thr Cys Arg Leu Gly Trp Ala Tyr Tyr Cys Ala Gly Gly Gly Ala 
                165                 170                 175     


Ala Ala Ala Met Leu Ile Cys Thr Trp Leu Ser Cys Phe Ala Gly Arg 
            180                 185                 190         


Asn Pro Lys Pro Val Ile Leu Val Glu Ser Ile Met Arg Asn Thr Asn 
        195                 200                 205             


Ser Tyr Ala Met Glu Leu Asp His Cys Leu Lys Pro 
    210                 215                 220 


<210>  6528
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  6528

Met Gly Val Ala Thr Thr Leu Gln Pro Pro Thr Thr Ser Lys Thr Leu 
1               5                   10                  15      


Gln Lys Gln His Leu Glu Ala Val Gly Ala Tyr Gln Tyr Val Leu Thr 
            20                  25                  30          


Phe Leu Phe Met Gly Pro Phe Phe Ser Leu Leu Val Phe Val Leu Leu 
        35                  40                  45              


Phe Thr Ser Leu Trp Pro Phe Ser Val Phe Tyr Leu Val Trp Leu Tyr 
    50                  55                  60                  


Val Asp Trp Asp Thr Pro Asn Gln Gly Gly Arg Arg Ser Glu Trp Ile 
65                  70                  75                  80  


Arg Asn Arg Ala Ile Trp Arg Gln Leu Arg Asp Tyr Tyr Pro Val Lys 
                85                  90                  95      


Leu Val Lys Thr Ala Glu Leu Pro Pro Asp Arg Asn Tyr Val Leu Gly 
            100                 105                 110         


Ala His Pro His Gly Ile Met Cys Thr Gly Phe Leu Cys Asn Phe Ser 
        115                 120                 125             


Thr Glu Ser Asn Gly Phe Ser Gln Leu Phe Pro Gly Leu Arg Pro Trp 
    130                 135                 140                 


Leu Ala Val Leu Ala Gly Leu Phe Tyr Leu Pro Val Tyr Arg Asp Tyr 
145                 150                 155                 160 


Ile Met Ser Phe Gly Leu Cys Pro Val Ser Arg Gln Ser Leu Asp Phe 
                165                 170                 175     


Ile Leu Ser Gln Pro Gln Leu Gly Gln Ala Val Val Ile Met Val Gly 
            180                 185                 190         


Gly Ala His Glu Ala Leu Tyr Ser Val Pro Gly Glu His Cys Leu Thr 
        195                 200                 205             


Leu Gln Lys Arg Lys Gly Phe Val Arg Leu Ala Leu Arg His Gly Ala 
    210                 215                 220                 


Ser Leu Val Pro Val Tyr Ser Phe Gly Glu Asn Asp Ile Phe Arg Leu 
225                 230                 235                 240 


Lys Ala Phe Ala Thr Gly Ser Trp Gln His Trp Cys Gln Leu Thr Phe 
                245                 250                 255     


Lys Lys Leu Met Gly Phe Ser Pro Cys Ile Phe Trp Gly Arg Gly Leu 
            260                 265                 270         


Phe Ser Ala Thr Ser Trp Gly Leu Leu Pro Phe Ala Val Pro Ile Thr 
        275                 280                 285             


Thr Val Val Gly Arg Pro Ile Pro Val Pro Gln Arg Leu His Pro Thr 
    290                 295                 300                 


Glu Glu Glu Val Asn His Tyr His Ala Leu Tyr Met Thr Ala Leu Glu 
305                 310                 315                 320 


Gln Leu Phe Glu Glu His Lys Glu Ser Cys Gly Val Pro Ala Ser Thr 
                325                 330                 335     


Cys Leu Thr Phe Ile 
            340     


<210>  6529
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  6529

Met Ala Gly Leu Asn Cys Gly Val Ser Ile Ala Leu Leu Gly Val Leu 
1               5                   10                  15      


Leu Leu Gly Ala Ala Arg Leu Pro Arg Gly Ala Glu Ala Phe Glu Ile 
            20                  25                  30          


Ala Leu Pro Arg Glu Ser Asn Ile Thr Val Leu Ile Lys Leu Gly Thr 
        35                  40                  45              


Pro Thr Leu Leu Ala Lys Pro Cys Tyr Ile Val Ile Ser Lys Arg His 
    50                  55                  60                  


Ile Thr Met Leu Ser Ile Lys Ser Gly Glu Arg Ile Val Phe Thr Phe 
65                  70                  75                  80  


Ser Cys Gln Ser Pro Glu Asn His Phe Val Ile Glu Ile Gln Lys Asn 
                85                  90                  95      


Ile Asp Cys Met Ser Gly Pro Cys Pro Phe Gly Glu Val Gln Leu Gln 
            100                 105                 110         


Pro Ser Thr Ser Leu Leu Pro Thr Leu Asn Arg Thr Phe Ile Trp Asp 
        115                 120                 125             


Val Lys Ala His Lys Ser Ile Gly Leu Glu Leu Gln Phe Ser Ile Pro 
    130                 135                 140                 


Arg Leu Arg Gln Ile Gly Pro Gly Glu Ser Cys Pro Asp Gly Val Thr 
145                 150                 155                 160 


His Ser Ile Ser Gly Arg Ile Asp Ala Thr Val Val Arg Ile Gly Thr 
                165                 170                 175     


Phe Cys Ser Asn Gly Thr Val Ser Arg Ile Lys Met Gln Glu Gly Val 
            180                 185                 190         


Lys Met Ala Leu His Leu Pro Trp Phe His Pro Arg Asn Val Ser Gly 
        195                 200                 205             


Phe Ser Ile Ala Asn Arg Ser Ser Ile Lys Arg Leu Cys Ile Ile Glu 
    210                 215                 220                 


Ser Val Phe Glu Gly Glu Gly Ser Ala Thr Leu Met Ser Ala Asn Tyr 
225                 230                 235                 240 


Pro Glu Gly Phe Pro Glu Asp Glu Leu Met Thr Trp Gln Phe Val Val 
                245                 250                 255     


Pro Ala His Leu Arg Ala Ser Val Ser Phe Leu Asn Phe Asn Leu Ser 
            260                 265                 270         


Asn Cys Glu Arg Lys Glu Glu Arg Val Glu Tyr Tyr Ile Pro Gly Ser 
        275                 280                 285             


Thr Thr Asn Pro Glu Val Phe Lys Leu Glu Asp Lys Gln Pro Gly Asn 
    290                 295                 300                 


Met Ala Gly Asn Phe Asn Leu Ser Leu Gln Gly Cys Asp Gln Asp Ala 
305                 310                 315                 320 


Gln Ser Pro Gly Ile Leu Arg Leu Gln Phe Gln Val Leu Val Gln His 
                325                 330                 335     


Pro Gln Asn Glu Ser Ser Glu 
            340             


<210>  6530
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  6530

Met Gly Ala Arg Gly Ala Pro Ser Arg Arg Arg Gln Ala Gly Arg Arg 
1               5                   10                  15      


Leu Arg Tyr Leu Pro Thr Gly Ser Phe Pro Phe Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Cys Ile Gln Leu Gly Gly Gly Gln Lys Lys Lys Glu Asn Leu 
        35                  40                  45              


Leu Ala Glu Lys Val Glu Gln Leu Met Glu Trp Ser Ser Arg Arg Ser 
    50                  55                  60                  


Ile Phe Arg Met Asn Gly Asp Lys Phe Arg Lys Phe Ile Lys Ala Pro 
65                  70                  75                  80  


Pro Arg Asn Tyr Ser Met Ile Val Met Phe Thr Ala Leu Gln Pro Gln 
                85                  90                  95      


Arg Gln Cys Ser Val Cys Arg Gln Ala Asn Glu Glu Tyr Gln Ile Leu 
            100                 105                 110         


Ala Asn Ser Trp Arg Tyr Ser Ser Ala Phe Cys Asn Lys Leu Phe Phe 
        115                 120                 125             


Ser Met Val Asp Tyr Asp Glu Gly Thr Asp Val Phe Gln Gln Leu Asn 
    130                 135                 140                 


Met Asn Ser Ala Pro Thr Phe Met His Phe Pro Pro Lys Gly Arg Pro 
145                 150                 155                 160 


Lys Arg Ala Asp Thr Phe Asp Leu Gln Arg Ile Gly Phe Ala Ala Glu 
                165                 170                 175     


Gln Leu Ala Lys Trp Ile Ala Asp Arg Thr Asp Val His Ile Arg Val 
            180                 185                 190         


Phe Arg Pro Pro Asn Tyr Ser Gly Thr Ile Ala Leu Ala Leu Leu Val 
        195                 200                 205             


Ser Leu Val Gly Gly Leu Leu Tyr Leu Arg Arg Asn Asn Leu Glu Phe 
    210                 215                 220                 


Ile Tyr Asn Lys Thr Gly Trp Ala Met Val Ser Leu Cys Ile Val Phe 
225                 230                 235                 240 


Ala Met Thr Ser Gly Gln Met Trp Asn His Ile Arg Gly Pro Pro Tyr 
                245                 250                 255     


Ala His Lys Asn Pro His Asn Gly Gln Val Ser Tyr Ile His Gly Ser 
            260                 265                 270         


Ser Gln Ala Gln Phe Val Ala Glu Ser His Ile Ile Leu Val Leu Asn 
        275                 280                 285             


Ala Ala Ile Thr Met Gly Met Val Leu Leu Asn Glu Ala Ala Thr Ser 
    290                 295                 300                 


Lys Gly Asp Val Gly Lys Arg Arg Ile Ile Cys Leu Val Gly Leu Gly 
305                 310                 315                 320 


Leu Val Val Phe Phe Phe Ser Phe Leu Leu Ser Ile Phe Arg Ser Lys 
                325                 330                 335     


Tyr His Gly Tyr Pro Tyr Ser Phe Leu Ile Lys 
            340                 345         


<210>  6531
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  6531

Met Gly Arg Pro Leu Leu Leu Pro Leu Leu Pro Leu Leu Leu Pro Pro 
1               5                   10                  15      


Ala Phe Leu Gln Pro Ser Gly Ser Thr Gly Ser Gly Pro Ser Tyr Leu 
            20                  25                  30          


Tyr Gly Val Thr Gln Pro Lys His Leu Ser Ala Ser Met Gly Gly Ser 
        35                  40                  45              


Val Glu Ile Pro Phe Ser Phe Tyr Tyr Pro Trp Glu Leu Ala Thr Ala 
    50                  55                  60                  


Pro Asp Val Arg Ile Ser Trp Arg Arg Gly His Phe His Arg Gln Ser 
65                  70                  75                  80  


Phe Tyr Ser Thr Arg Pro Pro Ser Ile His Lys Asp Tyr Val Asn Arg 
                85                  90                  95      


Leu Phe Leu Asn Trp Thr Glu Gly Gln Lys Ser Gly Phe Leu Arg Ile 
            100                 105                 110         


Ser Asn Leu Gln Lys Gln Asp Gln Ser Val Tyr Phe Cys Arg Val Glu 
        115                 120                 125             


Leu Asp Thr Arg Ser Ser Gly Arg Gln Gln Trp Gln Ser Ile Glu Gly 
    130                 135                 140                 


Thr Lys Leu Ser Ile Thr Gln Gly Gln Gln Arg Thr Lys Ala Thr Thr 
145                 150                 155                 160 


Pro Ala Arg Glu Pro Phe Gln Asn Thr Glu Glu Pro Tyr Glu Asn Ile 
                165                 170                 175     


Arg Asn Glu Gly Gln Asn Thr Asp Pro Lys Leu Asn Pro Lys Asp Asp 
            180                 185                 190         


Gly Ile Val Tyr Ala Ser Leu Ala Leu Ser Ser Ser Thr Ser Pro Arg 
        195                 200                 205             


Ala Pro Pro Ser His Arg Pro Leu Lys Ser Pro Gln Asn Glu Thr Leu 
    210                 215                 220                 


Tyr Ser Val Leu Lys Ala 
225                 230 


<210>  6532
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  6532

Met Gly Arg Pro Leu Leu Leu Pro Leu Leu Pro Leu Leu Leu Pro Pro 
1               5                   10                  15      


Ala Phe Leu Gln Pro Ser Gly Ser Thr Gly Ser Gly Pro Ser Tyr Leu 
            20                  25                  30          


Tyr Gly Val Thr Gln Pro Lys His Leu Ser Ala Ser Met Gly Gly Ser 
        35                  40                  45              


Val Glu Ile Pro Phe Ser Phe Tyr Tyr Pro Trp Glu Leu Ala Thr Ala 
    50                  55                  60                  


Pro Asp Val Arg Ile Ser Trp Arg Arg Gly His Phe His Arg Gln Ser 
65                  70                  75                  80  


Phe Tyr Ser Thr Arg Pro Pro Ser Ile His Lys Asp Tyr Val Asn Arg 
                85                  90                  95      


Leu Phe Leu Asn Trp Thr Glu Gly Gln Lys Ser Gly Phe Leu Arg Ile 
            100                 105                 110         


Ser Asn Leu Gln Lys Gln Asp Gln Ser Val Tyr Phe Cys Arg Val Glu 
        115                 120                 125             


Leu Asp Thr Arg Ser Ser Gly Arg Gln Gln Trp Gln Ser Ile Glu Gly 
    130                 135                 140                 


Thr Lys Leu Ser Ile Thr Gln Gly Asn Pro Ser Lys Thr Gln Arg Ser 
145                 150                 155                 160 


His Met Arg Ile Ser Gly Met Lys Asp Lys Ile Gln Ile Pro Ser 
                165                 170                 175 


<210>  6533
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  6533

Met Ser Ala Gln Cys Cys Ala Gly Gln Leu Ala Cys Cys Cys Gly Ser 
1               5                   10                  15      


Ala Gly Cys Ser Leu Cys Cys Asp Cys Cys Pro Arg Ile Arg Gln Ser 
            20                  25                  30          


Leu Ser Thr Arg Phe Met Tyr Ala Leu Tyr Phe Ile Leu Val Val Val 
        35                  40                  45              


Leu Cys Cys Ile Met Met Ser Thr Thr Val Ala His Lys Met Lys Glu 
    50                  55                  60                  


His Ile Pro Phe Phe Glu Asp Met Cys Lys Gly Ile Lys Ala Gly Asp 
65                  70                  75                  80  


Thr Cys Glu Lys Leu Val Gly Tyr Ser Ala Val Tyr Arg Val Cys Phe 
                85                  90                  95      


Gly Met Ala Cys Phe Phe Phe Ile Phe Cys Leu Leu Thr Leu Lys Ile 
            100                 105                 110         


Asn Asn Ser Lys Ser Cys Arg Ala His Ile His Asn Gly Phe Trp Phe 
        115                 120                 125             


Phe Lys Leu Leu Leu Leu Gly Ala Met Cys Ser Gly Ala Phe Phe Ile 
    130                 135                 140                 


Pro Asp Gln Asp Thr Phe Leu Asn Ala Trp Arg Tyr Val Gly Ala Val 
145                 150                 155                 160 


Gly Gly Phe Leu Phe Ile Gly Ile Gln Leu Leu Leu Leu Val Glu Phe 
                165                 170                 175     


Ala His Lys Trp Asn Lys Asn Trp Thr Ala Gly Thr Ala Ser Asn Lys 
            180                 185                 190         


Leu Trp Tyr Ala Ser Leu Ala Leu Val Thr Leu Ile Met Tyr Ser Ile 
        195                 200                 205             


Ala Thr Gly Gly Leu Val Leu Met Ala Val Phe Tyr Thr Gln Lys Asp 
    210                 215                 220                 


Ser Cys Met Glu Asn Lys Ile Leu Leu Gly Val Asn Gly Gly Leu Cys 
225                 230                 235                 240 


Leu Leu Ile Ser Leu Val Ala Ile Ser Pro Trp Val Gln Asn Arg Gln 
                245                 250                 255     


Pro His Ser Gly Leu Leu Gln Ser Gly Val Ile Ser Cys Tyr Val Thr 
            260                 265                 270         


Tyr Leu Thr Phe Ser Ala Leu Ser Ser Lys Pro Ala Glu Val Val Leu 
        275                 280                 285             


Asp Glu His Gly Lys Asn Val Thr Ile Cys Val Pro Asp Phe Gly Gln 
    290                 295                 300                 


Asp Leu Tyr Arg Asp Glu Asn Leu Val Thr Ile Leu Gly Thr Ser Leu 
305                 310                 315                 320 


Leu Ile Gly Cys Ile Leu Tyr Ser Cys Leu Thr Ser Thr Thr Arg Ser 
                325                 330                 335     


Ser Ser Asp Ala Leu Gln Gly Arg Tyr Ala Ala Pro Glu Leu Glu Ile 
            340                 345                 350         


Ala Arg Cys Cys Phe Cys Phe Ser Pro Gly Gly Glu Asp Thr Glu Glu 
        355                 360                 365             


Gln Gln Pro Gly Lys Glu Gly Pro Arg Val Ile Tyr Asp Glu Lys Lys 
    370                 375                 380                 


Gly Thr Val Tyr Ile Tyr Ser Tyr Phe His Phe Val Phe Phe Leu Ala 
385                 390                 395                 400 


Ser Leu Tyr Val Met Met Thr Val Thr Asn Trp Phe Asn His Val Arg 
                405                 410                 415     


Ser Ala Phe His Leu Leu Pro 
            420             


<210>  6534
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  6534

Met Thr Ser Glu Phe Phe Ser Ala Gln Leu Arg Ala Gln Ile Ser Asp 
1               5                   10                  15      


Asp Thr Thr His Pro Ile Ser Tyr Tyr Lys Pro Glu Phe Tyr Met Pro 
            20                  25                  30          


Asp Asp Gly Gly Thr Ala His Leu Ser Val Val Ala Glu Asp Gly Ser 
        35                  40                  45              


Ala Val Ser Ala Thr Ser Thr Ile Asn Leu Tyr Phe Gly Ser Lys Val 
    50                  55                  60                  


Arg Ser Pro Val Ser Gly Ile Leu Leu Asn Asn Glu Met Asp Asp Phe 
65                  70                  75                  80  


Ser Ser Thr Ser Ile Thr Asn Glu Phe Gly Val Pro Pro Ser Pro Ala 
                85                  90                  95      


Asn Phe Ile Gln Pro Gly Lys Gln Pro Leu Ser Ser Met Cys Pro Thr 
            100                 105                 110         


Ile Met Val Gly Gln Asp Gly Gln Val Arg Met Val Val Gly Ala Ala 
        115                 120                 125             


Gly Gly Thr Gln Ile Thr Met Ala Thr Ala Leu Ala Ile Ile Tyr Asn 
    130                 135                 140                 


Leu Trp Phe Gly Tyr Asp Val Lys Trp Ala Val Glu Glu Pro Arg Leu 
145                 150                 155                 160 


His Asn Gln Leu Leu Pro Asn Val Thr Thr Val Glu Arg Asn Ile Asp 
                165                 170                 175     


Gln Glu Val Thr Ala Ala Leu Glu Thr Arg His His His Thr Gln Ile 
            180                 185                 190         


Thr Ser Thr Phe Ile Ala Val Val Gln Ala Ile Val Arg Met Ala Gly 
        195                 200                 205             


Gly Trp Ala Ala Ala Ser Asp Ser Arg Lys Gly Gly Glu Pro Ala Gly 
    210                 215                 220                 


Tyr 
225 


<210>  6535
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  6535

Met Thr Ser Glu Phe Phe Ser Ala Gln Leu Arg Ala Gln Ile Ser Asp 
1               5                   10                  15      


Asp Thr Thr His Pro Ile Ser Tyr Tyr Lys Pro Glu Phe Tyr Met Pro 
            20                  25                  30          


Asp Asp Gly Gly Thr Ala His Leu Ser Val Val Ala Glu Asp Gly Ser 
        35                  40                  45              


Ala Val Ser Ala Thr Ser Thr Ile Asn Leu Tyr Phe Gly Ser Lys Val 
    50                  55                  60                  


Arg Ser Pro Val Ser Gly Ile Leu Leu Asn Asn Glu Met Asp Asp Phe 
65                  70                  75                  80  


Ser Ser Thr Ser Ile Thr Asn Glu Phe Gly Val Pro Pro Ser Pro Ala 
                85                  90                  95      


Asn Phe Ile Gln Pro Gly Lys Gln Pro Leu Ser Ser Met Cys Pro Thr 
            100                 105                 110         


Ile Met Val Gly Gln Asp Gly Gln Val Arg Met Val Val Gly Ala Ala 
        115                 120                 125             


Gly Gly Thr Gln Ile Thr Met Ala Thr Ala Leu Ala Ile Ile Tyr Asn 
    130                 135                 140                 


Leu Trp Phe Gly Tyr Asp Val Lys Trp Ala Val Glu Glu Pro Arg Leu 
145                 150                 155                 160 


His Asn Gln Leu Leu Pro Asn Val Thr Thr Val Glu Arg Asn Ile Asp 
                165                 170                 175     


Gln Glu Val Thr Ala Ala Leu Glu Thr Arg His His His Thr Gln Ile 
            180                 185                 190         


Thr Ser Thr Phe Ile Ala Val Val Gln Ala Ile Val Arg Met Ala Gly 
        195                 200                 205             


Gly Trp Ala Ala Ala Ser Asp Ser Arg Lys Gly Gly Glu Pro Ala Gly 
    210                 215                 220                 


Tyr 
225 


<210>  6536
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  6536

Met Ala Thr Ala Thr Glu Gln Trp Val Leu Val Glu Met Val Gln Ala 
1               5                   10                  15      


Leu Tyr Glu Ala Pro Ala Tyr His Leu Ile Leu Glu Gly Ile Leu Ile 
            20                  25                  30          


Leu Trp Ile Ile Arg Leu Leu Phe Ser Lys Thr Tyr Lys Leu Gln Glu 
        35                  40                  45              


Arg Ser Asp Leu Thr Val Lys Glu Lys Glu Glu Leu Ile Glu Glu Trp 
    50                  55                  60                  


Gln Pro Glu Pro Leu Val Pro Pro Val Pro Lys Asp His Pro Ala Leu 
65                  70                  75                  80  


Asn Tyr Asn Ile Val Ser Gly Pro Pro Ser His Lys Thr Val Val Asn 
                85                  90                  95      


Gly Lys Glu Cys Ile Asn Phe Ala Ser Phe Asn Phe Leu Gly Leu Leu 
            100                 105                 110         


Asp Asn Pro Arg Val Lys Ala Ala Ala Leu Ala Ser Leu Lys Lys Tyr 
        115                 120                 125             


Gly Val Gly Thr Cys Gly Pro Arg Gly Phe Tyr Gly Thr Phe Glu 
    130                 135                 140             


<210>  6537
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  6537

Met Pro Phe Gly Ile Arg Met Leu Leu Arg Ala His Lys Pro Gly Ser 
1               5                   10                  15      


Ser Arg Arg Ser Glu Met Thr Thr Ser Leu Asp Thr Val Glu Thr Phe 
            20                  25                  30          


Gly Thr Thr Ser Tyr Tyr Asp Asp Val Gly Leu Leu Cys Glu Lys Ala 
        35                  40                  45              


Asp Thr Arg Ala Leu Met Ala Gln Phe Val Pro Pro Leu Tyr Ser Leu 
    50                  55                  60                  


Val Phe Thr Val Gly Leu Leu Gly Asn Val Val Val Val Met Ile Leu 
65                  70                  75                  80  


Ile Lys Tyr Arg Arg Leu Arg Ile Met Thr Asn Ile Tyr Leu Leu Asn 
                85                  90                  95      


Leu Ala Ile Ser Asp Leu Leu Phe Leu Val Thr Leu Pro Phe Trp Ile 
            100                 105                 110         


His Tyr Val Arg Gly His Asn Trp Val Phe Gly His Gly Met Cys Lys 
        115                 120                 125             


Leu Leu Ser Gly Phe Tyr His Thr Gly Leu Tyr Ser Glu Ile Phe Phe 
    130                 135                 140                 


Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val 
145                 150                 155                 160 


Phe Ala Leu Arg Ala Arg Thr Val Thr Phe Gly Val Ile Thr Ser Ile 
                165                 170                 175     


Val Thr Trp Gly Leu Ala Val Leu Ala Ala Leu Pro Glu Phe Ile Phe 
            180                 185                 190         


Tyr Glu Thr Glu Glu Leu Phe Glu Glu Thr Leu Cys Ser Ala Leu Tyr 
        195                 200                 205             


Pro Glu Asp Thr Val Tyr Ser Trp Arg His Phe His Thr Leu Arg Met 
    210                 215                 220                 


Thr Ile Phe Cys Leu Val Leu Pro Leu Leu Val Met Ala Ile Cys Tyr 
225                 230                 235                 240 


Thr Gly Ile Ile Lys Thr Leu Leu Arg Cys Pro Ser Lys Lys Lys Tyr 
                245                 250                 255     


Lys Ala Ile Arg Leu Ile Phe Val Ile Met Ala Val Phe Phe Ile Phe 
            260                 265                 270         


Trp Thr Pro Tyr Asn Val Ala Ile Leu Leu Ser Ser Tyr Gln Ser Ile 
        275                 280                 285             


Leu Phe Gly Asn Asp Cys Glu Arg Ser Lys His Leu Asp Leu Val Met 
    290                 295                 300                 


Leu Val Thr Glu Val Ile Ala Tyr Ser His Cys Cys Met Asn Pro Val 
305                 310                 315                 320 


Ile Tyr Ala Phe Val Gly Glu Arg Phe Arg Lys Tyr Leu Arg His Phe 
                325                 330                 335     


Phe His Arg His Leu Leu Met His Leu Gly Arg Tyr Ile Pro Phe Leu 
            340                 345                 350         


Pro Ser Glu Lys Leu Glu Arg Thr Ser Ser Val Ser Pro Ser Thr Ala 
        355                 360                 365             


Glu Pro Glu Leu Ser Ile Val Phe 
    370                 375     


<210>  6538
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  6538

Met Thr Thr Ser Leu Asp Thr Val Glu Thr Phe Gly Thr Thr Ser Tyr 
1               5                   10                  15      


Tyr Asp Asp Val Gly Leu Leu Cys Glu Lys Ala Asp Thr Arg Ala Leu 
            20                  25                  30          


Met Ala Gln Phe Val Pro Pro Leu Tyr Ser Leu Val Phe Thr Val Gly 
        35                  40                  45              


Leu Leu Gly Asn Val Val Val Val Met Ile Leu Ile Lys Tyr Arg Arg 
    50                  55                  60                  


Leu Arg Ile Met Thr Asn Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp 
65                  70                  75                  80  


Leu Leu Phe Leu Val Thr Leu Pro Phe Trp Ile His Tyr Val Arg Gly 
                85                  90                  95      


His Asn Trp Val Phe Gly His Gly Met Cys Lys Leu Leu Ser Gly Phe 
            100                 105                 110         


Tyr His Thr Gly Leu Tyr Ser Glu Ile Phe Phe Ile Ile Leu Leu Thr 
        115                 120                 125             


Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe Ala Leu Arg Ala 
    130                 135                 140                 


Arg Thr Val Thr Phe Gly Val Ile Thr Ser Ile Val Thr Trp Gly Leu 
145                 150                 155                 160 


Ala Val Leu Ala Ala Leu Pro Glu Phe Ile Phe Tyr Glu Thr Glu Glu 
                165                 170                 175     


Leu Phe Glu Glu Thr Leu Cys Ser Ala Leu Tyr Pro Glu Asp Thr Val 
            180                 185                 190         


Tyr Ser Trp Arg His Phe His Thr Leu Arg Met Thr Ile Phe Cys Leu 
        195                 200                 205             


Val Leu Pro Leu Leu Val Met Ala Ile Cys Tyr Thr Gly Ile Ile Lys 
    210                 215                 220                 


Thr Leu Leu Arg Cys Pro Ser Lys Lys Lys Tyr Lys Ala Ile Arg Leu 
225                 230                 235                 240 


Ile Phe Val Ile Met Ala Val Phe Phe Ile Phe Trp Thr Pro Tyr Asn 
                245                 250                 255     


Val Ala Ile Leu Leu Ser Ser Tyr Gln Ser Ile Leu Phe Gly Asn Asp 
            260                 265                 270         


Cys Glu Arg Ser Lys His Leu Asp Leu Val Met Leu Val Thr Glu Val 
        275                 280                 285             


Ile Ala Tyr Ser His Cys Cys Met Asn Pro Val Ile Tyr Ala Phe Val 
    290                 295                 300                 


Gly Glu Arg Phe Arg Lys Tyr Leu Arg His Phe Phe His Arg His Leu 
305                 310                 315                 320 


Leu Met His Leu Gly Arg Tyr Ile Pro Phe Leu Pro Ser Glu Lys Leu 
                325                 330                 335     


Glu Arg Thr Ser Ser Val Ser Pro Ser Thr Ala Glu Pro Glu Leu Ser 
            340                 345                 350         


Ile Val Phe 
        355 


<210>  6539
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  6539

Met Ala Met Ala Gln Lys Leu Ser His Leu Leu Pro Ser Leu Arg Gln 
1               5                   10                  15      


Val Ile Gln Glu Pro Gln Leu Ser Leu Gln Pro Glu Pro Val Phe Thr 
            20                  25                  30          


Val Asp Arg Ala Glu Val Pro Pro Leu Phe Trp Lys Pro Tyr Ile Tyr 
        35                  40                  45              


Ala Gly Tyr Arg Pro Leu His Gln Thr Trp Arg Phe Tyr Phe Arg Thr 
    50                  55                  60                  


Leu Phe Gln Gln His Asn Glu Ala Val Asn Val Trp Thr His Leu Leu 
65                  70                  75                  80  


Ala Ala Leu Val Leu Leu Leu Arg Leu Ala Leu Phe Val Glu Thr Val 
                85                  90                  95      


Asp Phe Trp Gly Asp Pro His Ala Leu Pro Leu Phe Ile Ile Val Leu 
            100                 105                 110         


Ala Ser Phe Thr Tyr Leu Ser Phe Ser Ala Leu Ala His Leu Leu Gln 
        115                 120                 125             


Ala Lys Ser Glu Phe Trp His Tyr Ser Phe Phe Phe Leu Asp Tyr Val 
    130                 135                 140                 


Gly Val Ala Val Tyr Gln Phe Gly Ser Ala Leu Ala His Phe Tyr Tyr 
145                 150                 155                 160 


Ala Ile Glu Pro Ala Trp His Ala Gln Val Gln Ala Val Phe Leu Pro 
                165                 170                 175     


Met Ala Ala Phe Leu Ala Trp Leu Ser Cys Ile Gly Ser Cys Tyr Asn 
            180                 185                 190         


Lys Tyr Ile Gln Lys Pro Gly Leu Leu Gly Arg Thr Cys Gln Glu Val 
        195                 200                 205             


Pro Ser Val Leu Ala Tyr Ala Leu Asp Ile Ser Pro Val Val His Arg 
    210                 215                 220                 


Ile Phe Val Ser Ser Asp Pro Thr Thr Asp Asp Pro Ala Leu Leu Tyr 
225                 230                 235                 240 


His Lys Cys Gln Val Val Phe Phe Leu Leu Ala Ala Ala Phe Phe Ser 
                245                 250                 255     


Thr Phe Met Pro Glu Arg Trp Phe Pro Gly Ser Cys His Val Phe Gly 
            260                 265                 270         


Gln Gly His Gln Leu Phe His Ile Phe Leu Val Leu Cys Thr Leu Ala 
        275                 280                 285             


Gln Leu Glu Ala Val Ala Leu Asp Tyr Glu Ala Arg Arg Pro Ile Tyr 
    290                 295                 300                 


Glu Pro Leu His Thr His Trp Pro His Asn Phe Ser Gly Leu Phe Leu 
305                 310                 315                 320 


Leu Thr Val Gly Ser Ser Ile Leu Thr Ala Phe Leu Leu Ser Gln Leu 
                325                 330                 335     


Val Gln Arg Lys Leu Asp Gln Lys Thr Lys 
            340                 345     


<210>  6540
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  6540

Met Glu Thr Arg Gln Val Ser Arg Ser Pro Arg Val Arg Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Val Val Pro Trp Gly Val Arg Thr Ala Ser 
            20                  25                  30          


Gly Val Ala Leu Pro Pro Val Gly Val Leu Ser Leu Arg Pro Pro Gly 
        35                  40                  45              


Arg Ala Trp Ala Asp Pro Ala Thr Pro Arg Pro Arg Arg Ser Leu Ala 
    50                  55                  60                  


Leu Ala Asp Asp Ala Ala Phe Arg Glu Arg Ala Arg Leu Leu Ala Ala 
65                  70                  75                  80  


Leu Glu Arg Arg His Trp Leu Asn Ser Tyr Met His Lys Leu Leu Val 
                85                  90                  95      


Leu Asp Ala Pro 
            100 


<210>  6541
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  6541

Met Thr Thr Ser Arg Cys Ser His Leu Pro Glu Val Leu Pro Asp Cys 
1               5                   10                  15      


Thr Ser Ser Ala Ala Pro Val Val Lys Thr Val Glu Asp Cys Gly Ser 
            20                  25                  30          


Leu Val Asn Gly Gln Pro Gln Tyr Val Met Gln Val Ser Ala Lys Asp 
        35                  40                  45              


Gly Gln Leu Leu Ser Thr Val Val Arg Thr Leu Ala Thr Gln Ser Pro 
    50                  55                  60                  


Phe Asn Asp Arg Pro Met Cys Arg Ile Cys His Glu Gly Ser Ser Gln 
65                  70                  75                  80  


Glu Asp Leu Leu Ser Pro Cys Glu Cys Thr Gly Thr Leu Gly Thr Ile 
                85                  90                  95      


His Arg Ser Cys Leu Glu His Trp Leu Ser Ser Ser Asn Thr Ser Tyr 
            100                 105                 110         


Cys Glu Leu Cys His Phe Arg Phe Ala Val Glu Arg Lys Pro Arg Pro 
        115                 120                 125             


Leu Val Glu Trp Leu Arg Asn Pro Gly Pro Gln His Glu Lys Arg Thr 
    130                 135                 140                 


Leu Phe Gly Asp Met Val Cys Phe Leu Phe Ile Thr Pro Leu Ala Thr 
145                 150                 155                 160 


Ile Ser Gly Trp Leu Cys Leu Arg Gly Ala Val Asp His Leu His Phe 
                165                 170                 175     


Ser Ser Arg Leu Glu Ala Val Gly Leu Ile Ala Leu Thr Val Ala Leu 
            180                 185                 190         


Phe Thr Ile Tyr Leu Phe Trp Thr Leu Val Ser Phe Arg Tyr His Cys 
        195                 200                 205             


Arg Leu Tyr Asn Glu Trp Arg Arg Thr Asn Gln Arg Val Ile Leu Leu 
    210                 215                 220                 


Ile Pro Lys Ser Val Asn Val Pro Ser Asn Gln Pro Ser Leu Leu Gly 
225                 230                 235                 240 


Leu His Ser Val Lys Arg Asn Ser Lys Glu Thr Val Val 
                245                 250             


<210>  6542
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  6542

Met Trp Trp Phe Gln Gln Gly Leu Ser Phe Leu Pro Ser Ala Leu Val 
1               5                   10                  15      


Ile Trp Thr Ser Ala Ala Phe Ile Phe Ser Tyr Ile Thr Ala Val Thr 
            20                  25                  30          


Leu His His Ile Asp Pro Ala Leu Pro Tyr Ile Ser Asp Thr Gly Thr 
        35                  40                  45              


Val Ala Pro Glu Lys Cys Leu Phe Gly Ala Met Leu Asn Ile Ala Ala 
    50                  55                  60                  


Val Leu Cys Ile Ala Thr Ile Tyr Val Arg Tyr Lys Gln Val His Ala 
65                  70                  75                  80  


Leu Ser Pro Glu Glu Asn Val Ile Ile Lys Leu Asn Lys Ala Gly Leu 
                85                  90                  95      


Val Leu Gly Ile Leu Ser Cys Leu Gly Leu Ser Ile Val Ala Asn Phe 
            100                 105                 110         


Gln Lys Thr Thr Leu Phe Ala Ala His Val Ser Gly Ala Val Leu Thr 
        115                 120                 125             


Phe Gly Met Gly Ser Leu Tyr Met Phe Val Gln Thr Ile Leu Ser Tyr 
    130                 135                 140                 


Gln Met Gln Pro Lys Ile His Gly Lys Gln Val Phe Trp Ile Arg Leu 
145                 150                 155                 160 


Leu Leu Val Ile Trp Cys Gly Val Ser Ala Leu Ser Met Leu Thr Cys 
                165                 170                 175     


Ser Ser Val Leu His Ser Gly Asn Phe Gly Thr Asp Leu Glu Gln Lys 
            180                 185                 190         


Leu His Trp Asn Pro Glu Asp Lys Gly Tyr Val Leu His Met Ile Thr 
        195                 200                 205             


Thr Ala Ala Glu Trp Ser Met Ser Phe Ser Phe Phe Gly Phe Phe Leu 
    210                 215                 220                 


Thr Tyr Ile Arg Asp Phe Gln Lys Ile Ser Leu Arg Val Glu Ala Asn 
225                 230                 235                 240 


Leu His Gly Leu Thr Leu Tyr Asp Thr Ala Pro Cys Pro Ile Asn Asn 
                245                 250                 255     


Glu Arg Thr Arg Leu Leu Ser Arg Asp Ile 
            260                 265     


<210>  6543
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  6543

Met Thr Thr Asp Ser Tyr Ser Pro Thr Ser Pro Asp Ala Glu Ala Ser 
1               5                   10                  15      


Met Ala Val Ile Ser Leu Leu Phe Leu Ala Val Met Tyr Val Val His 
            20                  25                  30          


His Pro Leu Met Val Ser Asp Arg Met Asp Leu Asp Thr Leu Ala Arg 
        35                  40                  45              


Ser Arg Gln Leu Glu Lys Arg Met Ser Glu Glu Met Arg Leu Leu Glu 
    50                  55                  60                  


Met Glu Phe Glu Glu Arg Lys Arg Ala Ala Glu Gln Arg Gln Lys Ala 
65                  70                  75                  80  


Glu Asn Phe Trp Thr Gly Asp Thr Ser Ser Asp Gln Leu Val Leu Gly 
                85                  90                  95      


Lys Lys Asp Met Gly Trp Pro Phe Gln Ala Asp Gly Gln Glu Gly Pro 
            100                 105                 110         


Leu Gly Trp Met Leu Gly Asn Leu Trp Asn Thr Gly Leu Phe Cys Leu 
        115                 120                 125             


Phe Leu Val Phe Glu Leu Leu Arg Gln Asn Met Gln His Glu Pro Ala 
    130                 135                 140                 


Phe Asp Ser Ser Ser Glu Glu Glu Glu Glu Glu Val Arg Val Val Pro 
145                 150                 155                 160 


Val Thr Ser Tyr Asn Trp Leu Thr Asp Phe Pro Ser Gln Glu Ala Leu 
                165                 170                 175     


Asp Ser Phe Tyr Lys His Tyr Val Gln Asn Ala Ile Arg Asp Leu Pro 
            180                 185                 190         


Cys Thr Cys Glu Phe Val Glu Ser Phe Val Asp Asp Leu Ile Glu Ala 
        195                 200                 205             


Cys Arg Val Leu Ser Arg Gln Glu Ala His Pro Gln Leu Glu Asp Cys 
    210                 215                 220                 


Leu Gly Ile Gly Ala Ala Phe Glu Lys Trp Gly Thr Leu His Glu Thr 
225                 230                 235                 240 


Gln Lys Phe Asp Ile Leu Val Pro Ile Val Pro Pro Gln Gly Thr Met 
                245                 250                 255     


Phe Val Leu Glu Met Arg Asp Pro Ala Leu Gly Arg Arg Cys Gly Cys 
            260                 265                 270         


Val Leu Val Glu Ser Glu Cys Val Cys Lys Arg Glu Lys Leu Leu Gly 
        275                 280                 285             


Asp Val Leu Cys Leu Val His His His Arg Asp Pro Ser Ala Val Leu 
    290                 295                 300                 


Gly Lys Cys Ser Ser Ser Ile Lys Ala Ala Leu Cys Thr Gly Phe His 
305                 310                 315                 320 


Leu Asp Val Cys Lys Thr Val Gln Trp Phe Arg Asn Met Met Gly Asn 
                325                 330                 335     


Ala Trp Ala Leu Val Ala His Lys Tyr Asp Phe Lys Leu Ser Leu Pro 
            340                 345                 350         


Pro Ser Thr Thr Ser Cys Lys Leu Arg Leu Asp Tyr Arg Ser Gly Arg 
        355                 360                 365             


Phe Leu Ser Ile His Leu Val Leu Gly Val Gln Arg Glu Asp Thr Leu 
    370                 375                 380                 


Val Tyr Leu Val Ser Gln Ala Pro Asp Gln Glu Gln Leu Thr Ser Val 
385                 390                 395                 400 


Asp Trp Pro Glu Ser Phe Val Ala Cys Glu His Leu Phe Leu Lys Leu 
                405                 410                 415     


Val Gly Arg Phe Ala Pro Glu Asn Thr Cys His Leu Lys Cys Leu Gln 
            420                 425                 430         


Ile Ile Leu Ser Leu Arg Gln His Gln Ser Leu Pro His Gly Ala Ser 
        435                 440                 445             


Arg Pro Ile Leu Thr Ser Tyr His Phe Lys Thr Ala Leu Met His Leu 
    450                 455                 460                 


Leu Leu Arg Leu Pro Leu Thr Asp Trp Ala His Asn Met Leu Ser Gln 
465                 470                 475                 480 


Arg Leu Gln Asp Ile Leu Trp Phe Leu Gly Arg Gly Leu Gln Gln Arg 
                485                 490                 495     


Ser Leu His His Phe Leu Ile Gly Asn Asn Phe Leu Pro Leu Thr Ile 
            500                 505                 510         


Pro Ile Pro Lys Thr Phe Arg Asn Ala Glu Pro Val Asn Leu Phe Gln 
        515                 520                 525             


His Leu Val Leu Asn Pro Lys Ala His Ser Gln Ala Val Glu Glu Phe 
    530                 535                 540                 


Gln Asn Leu Leu Thr Gln Val Lys Thr Leu Pro His Ala Pro Leu Ala 
545                 550                 555                 560 


Ala Ala Pro 
            


<210>  6544
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  6544

Met Ala Arg Arg His Cys Phe Ser Tyr Trp Leu Leu Val Cys Trp Leu 
1               5                   10                  15      


Val Val Thr Val Ala Glu Gly Gln Glu Glu Val Phe Thr Pro Pro Gly 
            20                  25                  30          


Asp Ser Gln Asn Asn Ala Asp Ala Thr Asp Cys Gln Ile Phe Thr Leu 
        35                  40                  45              


Thr Pro Pro Pro Ala Pro Arg Ser Pro Val Thr Arg Ala Gln Pro Ile 
    50                  55                  60                  


Thr Lys Thr Pro Arg Cys Pro Phe His Phe Phe Pro Arg Arg Pro Arg 
65                  70                  75                  80  


Ile His Phe Arg Phe Pro Asn Arg Pro Phe Val Pro Ser Arg Cys Asn 
                85                  90                  95      


His Arg Phe Pro Phe Gln Pro Phe Tyr Trp Pro His Arg Tyr Leu Thr 
            100                 105                 110         


Tyr Arg Tyr Phe Pro Arg Arg Arg Leu Gln Arg Gly Ser Ser Ser Glu 
        115                 120                 125             


Glu Ser 
    130 


<210>  6545
<211>  618
<212>  PRT
<213>  Homo sapiens

<400>  6545

Met Glu Val Lys Asn Phe Ala Val Trp Asp Tyr Val Val Phe Ala Ala 
1               5                   10                  15      


Leu Phe Phe Ile Ser Ser Gly Ile Gly Val Phe Phe Ala Ile Lys Glu 
            20                  25                  30          


Arg Lys Lys Ala Thr Ser Arg Glu Phe Leu Val Gly Gly Arg Gln Met 
        35                  40                  45              


Ser Phe Gly Pro Val Gly Leu Ser Leu Thr Ala Ser Phe Met Ser Ala 
    50                  55                  60                  


Val Thr Val Leu Gly Thr Pro Ser Glu Val Tyr Arg Phe Gly Ala Ser 
65                  70                  75                  80  


Phe Leu Val Phe Phe Ile Ala Tyr Leu Phe Val Ile Leu Leu Thr Ser 
                85                  90                  95      


Glu Leu Phe Leu Pro Val Phe Tyr Arg Ser Gly Ile Thr Ser Thr Tyr 
            100                 105                 110         


Glu Tyr Leu Gln Leu Arg Phe Asn Lys Pro Val Arg Tyr Ala Ala Thr 
        115                 120                 125             


Val Ile Tyr Ile Val Gln Thr Ile Leu Tyr Thr Gly Val Val Val Tyr 
    130                 135                 140                 


Ala Pro Ala Leu Ala Leu Asn Gln Val Thr Gly Phe Asp Leu Trp Gly 
145                 150                 155                 160 


Ser Val Phe Ala Thr Gly Ile Val Cys Thr Phe Tyr Cys Thr Leu Gly 
                165                 170                 175     


Gly Leu Lys Ala Val Val Trp Thr Asp Ala Phe Gln Met Val Val Met 
            180                 185                 190         


Ile Val Gly Phe Leu Thr Val Leu Ile Gln Gly Ser Thr His Ala Gly 
        195                 200                 205             


Gly Phe His Asn Val Leu Glu Gln Ser Thr Asn Gly Ser Arg Leu His 
    210                 215                 220                 


Ile Phe Asp Phe Asp Val Asp Pro Leu Arg Arg His Thr Phe Trp Thr 
225                 230                 235                 240 


Ile Thr Val Gly Gly Thr Phe Thr Trp Leu Gly Ile Tyr Gly Val Asn 
                245                 250                 255     


Gln Ser Thr Ile Gln Arg Cys Ile Ser Cys Lys Thr Glu Lys His Ala 
            260                 265                 270         


Lys Leu Ala Leu Tyr Phe Asn Leu Leu Gly Leu Trp Ile Ile Leu Val 
        275                 280                 285             


Cys Ala Val Phe Ser Gly Leu Ile Met Tyr Ser His Phe Lys Asp Cys 
    290                 295                 300                 


Asp Pro Trp Thr Ser Gly Ile Ile Ser Ala Pro Asp Gln Leu Met Pro 
305                 310                 315                 320 


Tyr Phe Val Met Glu Ile Phe Ala Thr Met Pro Gly Leu Pro Gly Leu 
                325                 330                 335     


Phe Val Ala Cys Ala Phe Ser Gly Thr Leu Ser Thr Val Ala Ser Ser 
            340                 345                 350         


Ile Asn Ala Leu Ala Thr Val Thr Phe Glu Asp Phe Val Lys Ser Cys 
        355                 360                 365             


Phe Pro His Leu Ser Asp Lys Leu Ser Thr Trp Ile Ser Lys Gly Leu 
    370                 375                 380                 


Cys Leu Leu Phe Gly Val Met Cys Thr Ser Met Ala Val Ala Ala Ser 
385                 390                 395                 400 


Val Met Gly Gly Val Val Gln Ala Ser Leu Ser Ile His Gly Met Cys 
                405                 410                 415     


Gly Gly Pro Met Leu Gly Leu Phe Ser Leu Gly Ile Val Phe Pro Phe 
            420                 425                 430         


Val Asn Trp Lys Gly Ala Leu Gly Gly Leu Leu Thr Gly Ile Thr Leu 
        435                 440                 445             


Ser Phe Trp Val Ala Ile Gly Ala Phe Ile Tyr Pro Ala Pro Ala Ser 
    450                 455                 460                 


Lys Thr Trp Pro Leu Pro Leu Ser Thr Asp Gln Cys Ile Lys Ser Asn 
465                 470                 475                 480 


Val Thr Ala Thr Gly Pro Pro Val Leu Ser Ser Arg Pro Gly Ile Ala 
                485                 490                 495     


Asp Thr Trp Tyr Ser Ile Ser Tyr Leu Tyr Tyr Ser Ala Val Gly Cys 
            500                 505                 510         


Leu Gly Cys Ile Val Ala Gly Val Ile Ile Ser Leu Ile Thr Gly Arg 
        515                 520                 525             


Gln Arg Gly Glu Asp Ile Gln Pro Leu Leu Ile Arg Pro Val Cys Asn 
    530                 535                 540                 


Leu Phe Cys Phe Trp Ser Lys Lys Tyr Lys Thr Leu Cys Trp Cys Gly 
545                 550                 555                 560 


Val Gln His Asp Ser Gly Thr Glu Gln Glu Asn Leu Glu Asn Gly Ser 
                565                 570                 575     


Ala Arg Lys Gln Gly Ala Glu Ser Val Leu Gln Asn Gly Leu Arg Arg 
            580                 585                 590         


Glu Ser Leu Val His Val Pro Gly Tyr Asp Pro Lys Asp Lys Ser Tyr 
        595                 600                 605             


Asn Asn Met Ala Phe Glu Thr Thr His Phe 
    610                 615             


<210>  6546
<211>  368
<212>  PRT
<213>  Homo sapiens

<400>  6546

Met Glu Gly Leu Val Phe Leu Asn Ala Leu Ala Thr Arg Leu Leu Phe 
1               5                   10                  15      


Leu Leu His Ser Leu Val Gly Val Trp Arg Val Thr Glu Val Lys Lys 
            20                  25                  30          


Glu Pro Arg Tyr Trp Leu Leu Ala Leu Leu Asn Leu Leu Leu Phe Leu 
        35                  40                  45              


Glu Thr Ala Leu Thr Leu Lys Phe Lys Arg Gly Arg Gly Tyr Lys Trp 
    50                  55                  60                  


Phe Ser Pro Ala Ile Phe Leu Tyr Leu Ile Ser Ile Val Pro Ser Leu 
65                  70                  75                  80  


Trp Leu Leu Glu Leu His His Glu Thr Gln Tyr Cys Ser Ile Gln Ala 
                85                  90                  95      


Glu Gly Thr Ser Gln Asn Thr Ser Arg Lys Glu Asp Phe Asn Gln Thr 
            100                 105                 110         


Leu Thr Ser Asn Glu Gln Thr Ser Arg Ala Asp Asp Leu Ile Glu Thr 
        115                 120                 125             


Ala Lys Val Phe Val Asn Asn Leu Ser Thr Val Cys Glu Lys Val Trp 
    130                 135                 140                 


Thr Leu Gly Leu His Gln Thr Phe Leu Leu Met Leu Ile Ile Gly Arg 
145                 150                 155                 160 


Trp Leu Leu Pro Ile Gly Gly Gly Ile Thr Arg Asp Gln Leu Ser Gln 
                165                 170                 175     


Leu Leu Leu Met Phe Val Gly Thr Ala Ala Asp Ile Leu Glu Phe Thr 
            180                 185                 190         


Ser Glu Thr Leu Glu Glu Gln Asn Val Arg Asn Ser Pro Ala Leu Val 
        195                 200                 205             


Tyr Ala Ile Leu Val Ile Trp Thr Trp Ser Met Leu Gln Phe Pro Leu 
    210                 215                 220                 


Asp Leu Ala Val Gln Asn Val Val Cys Pro Val Ser Val Thr Glu Arg 
225                 230                 235                 240 


Gly Phe Pro Ser Leu Phe Phe Cys Gln Tyr Ser Ala Asp Leu Trp Asn 
                245                 250                 255     


Ile Gly Ile Ser Val Phe Ile Gln Asp Gly Pro Phe Leu Val Val Arg 
            260                 265                 270         


Leu Ile Leu Met Thr Tyr Phe Lys Val Ile Asn Gln Met Leu Val Phe 
        275                 280                 285             


Phe Ala Ala Lys Asn Phe Leu Val Val Val Leu Gln Leu Tyr Arg Leu 
    290                 295                 300                 


Val Val Leu Ala Leu Ala Val Arg Ala Ser Leu Arg Ser Gln Ser Glu 
305                 310                 315                 320 


Gly Leu Lys Gly Glu His Gly Cys Arg Ala Gln Thr Ser Glu Ser Gly 
                325                 330                 335     


Pro Ser Gln Arg Asp Trp Gln Asn Glu Ser Lys Glu Gly Leu Ala Ile 
            340                 345                 350         


Pro Leu Arg Gly Ser Pro Val Thr Ser Asp Asp Ser His His Thr Pro 
        355                 360                 365             


<210>  6547
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  6547

Met Arg Gly Thr Ser Cys Val Gly Gly Gly Ala Glu Ser Pro Gly Gly 
1               5                   10                  15      


Ala Gly Leu Ser Glu Gly Pro Arg Gly Arg Trp Leu Arg Leu Ala Pro 
            20                  25                  30          


Val Cys Ala Tyr Phe Leu Cys Val Ser Leu Ala Ala Val Leu Leu Ala 
        35                  40                  45              


Val Tyr Tyr Gly Leu Ile Trp Val Pro Thr Arg Ser Pro Ala Ala Pro 
    50                  55                  60                  


Ala Gly Pro Gln Pro Ser Ala Pro Ser Pro Pro Cys Ala Ala Arg Pro 
65                  70                  75                  80  


Gly Val Pro Pro Val Pro Ala Pro Ala Ala Ala Ser Leu Ser Cys Leu 
                85                  90                  95      


Leu Gly Val Pro Gly Gly Pro Arg Pro Gln Leu Gln Leu Pro Leu Ser 
            100                 105                 110         


Arg Arg Arg Arg Tyr Ser Asp Pro Asp Arg Arg Pro Ser Arg Gln Thr 
        115                 120                 125             


Pro Arg Glu Thr Pro Glu Ala Ala Glu Gly Arg Arg Pro Gly 
    130                 135                 140         


<210>  6548
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  6548

Met Ser Glu Lys Gln Met Lys Glu Ala Phe Val Ser Asn Leu Asn Gly 
1               5                   10                  15      


Thr Thr Val Leu Glu Ile Thr Gln Gly Leu Cys Phe Pro Ala Phe Cys 
            20                  25                  30          


Ile Leu Cys Arg Gly Phe Leu Ile Ile Phe Ser Gln Tyr Leu Cys Ser 
        35                  40                  45              


Phe Ser Pro Thr Trp Lys Thr Arg Phe Leu Thr Asp Phe Val Val Leu 
    50                  55                  60                  


Ile Val Pro Met Val Ala Thr Leu Thr Ile Trp Ala Ser Phe Ile Leu 
65                  70                  75                  80  


Leu Glu Leu Leu Gly Val Ile Ile Phe Gly Ala Gly Leu Leu Tyr Gln 
                85                  90                  95      


Ile Tyr Arg Arg Arg Thr Cys Tyr Ala Arg Leu Pro Phe Leu Lys Ile 
            100                 105                 110         


Leu Glu Lys Phe Leu Asn Ile Ser Leu Glu Ser Glu Tyr Asn Pro Ala 
        115                 120                 125             


Ile Ser Cys Phe Arg Val Ile Thr Ser Ala Phe Thr Ala Ile Ala Ile 
    130                 135                 140                 


Leu Ala Val Asp Phe Pro Leu Phe Pro Arg Arg Phe Ala Lys Thr Glu 
145                 150                 155                 160 


Leu Tyr Gly Thr Gly Ala Met Asp Phe Gly Val Gly Gly Phe Val Phe 
                165                 170                 175     


Gly Ser Ala Met Val Cys Leu Glu Val Arg Arg Arg Lys Tyr Met Glu 
            180                 185                 190         


Gly Ser Lys Leu His Tyr Phe Thr Asn Ser Leu Tyr Ser Val Trp Pro 
        195                 200                 205             


Leu Val Phe Leu Gly Ile Gly Arg Leu Ala Ile Ile Lys Ser Ile Gly 
    210                 215                 220                 


Tyr Gln Glu His Leu Thr Glu Tyr Gly Val His Trp Asn Phe Phe Phe 
225                 230                 235                 240 


Thr Ile Ile Val Val Lys Leu Ile Thr Pro Leu Leu Leu Ile Ile Phe 
                245                 250                 255     


Pro Leu Asn Lys Ser Trp Ile Ile Ala Leu Gly Ile Thr Val Leu Tyr 
            260                 265                 270         


Gln Leu Ala Leu Asp Phe Thr Ser Leu Lys Arg Leu Ile Leu Tyr Gly 
        275                 280                 285             


Thr Asp Gly Ser Gly Thr Arg Val Gly Leu Leu Asn Ala Asn Arg Glu 
    290                 295                 300                 


Gly Ile Ile Ser Thr Leu Gly Tyr Val Ala Ile His Met Ala Gly Val 
305                 310                 315                 320 


Gln Thr Gly Leu Tyr Met His Lys Asn Arg Ser His Ile Lys Asp Leu 
                325                 330                 335     


Ile Lys Val Ala Cys Phe Leu Leu Leu Ala Ala Ile Ser Leu Phe Ile 
            340                 345                 350         


Ser Leu Tyr Val Val Gln Val Asn Val Glu Ala Val Ser Arg Arg Met 
        355                 360                 365             


Ala Asn Leu Ala Phe Cys Ile Trp Ile Val Ala Ser Ser Leu Ile Leu 
    370                 375                 380                 


Leu Ser Ser Leu Leu Leu Gly Asp Ile Ile Leu Ser Phe Ala Lys Phe 
385                 390                 395                 400 


Leu Ile Lys Gly Ala Leu Val Pro Cys Ser Trp Lys Leu Ile Gln Ser 
                405                 410                 415     


Pro Val Thr Asn Lys Lys His Ser Glu Ser Leu Val Pro Glu Ala Glu 
            420                 425                 430         


Arg Met Glu Pro Ser Leu Cys Leu Ile Thr Ala Leu Asn Arg Lys Gln 
        435                 440                 445             


Leu Ile Phe Phe Leu Leu Ser Asn Ile Thr Thr Gly Leu Ile Asn Leu 
    450                 455                 460                 


Met Val Asp Thr Leu His Ser Ser Thr Leu Trp Ala Leu Phe Val Val 
465                 470                 475                 480 


Asn Leu Tyr Met Phe Ser Asn Cys Leu Ile Val Tyr Val Leu Tyr Leu 
                485                 490                 495     


Gln Asp Lys Thr Val Gln Phe Trp 
            500                 


<210>  6549
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  6549

Met Leu Leu Lys Val Arg Arg Ala Ser Leu Lys Pro Pro Ala Thr Pro 
1               5                   10                  15      


His Gln Gly Ala Phe Arg Ala Gly Asn Val Ile Gly Gln Leu Ile Tyr 
            20                  25                  30          


Leu Leu Thr Trp Ser Leu Phe Thr Ala Trp Leu Arg Pro Pro Thr Leu 
        35                  40                  45              


Leu Gln Gly Pro Arg Thr Ser Pro Gln Gly Ser Pro Pro Arg Ser Pro 
    50                  55                  60                  


Trp Gly Asp Cys Ala Glu Pro Ser Cys Leu Cys Glu Met Lys Ile Arg 
65                  70                  75                  80  


Arg Arg Arg His Glu Gly Pro Ala Trp Gly Gln Ser Gly Phe Leu Ala 
                85                  90                  95      


Gly Gly Leu His Leu Val Pro Ser Ser Leu Ser Leu Ala Ala Cys Gly 
            100                 105                 110         


Val Val Arg Met Lys Gly Leu Trp Gly Arg Gly Ala Gly Ile Arg Gly 
        115                 120                 125             


Arg 
    


<210>  6550
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  6550

Met Lys Arg Ser Lys Glu Leu Ile Thr Lys Asn His Ser Gln Glu Glu 
1               5                   10                  15      


Thr Ser Ile Leu Arg Cys Trp Lys Cys Arg Lys Cys Ile Ala Ser Ser 
            20                  25                  30          


Gly Cys Phe Met Glu Tyr Leu Glu Asn Gln Val Ile Lys Asp Lys Asp 
        35                  40                  45              


Asp Ser Val Asp Ala Gln Asn Ile Cys His Val Trp His Met Asn Val 
    50                  55                  60                  


Glu Ala Leu Pro Glu Trp Ile Ser Cys Leu Ile Gln Lys Ala Gln Trp 
65                  70                  75                  80  


Thr Val Gly Lys Leu Asn Cys Pro Phe Cys Gly Ala Arg Leu Gly Gly 
                85                  90                  95      


Phe Asn Phe Val Ser Thr Pro Lys Cys Ser Cys Gly Gln Leu Ala Ala 
            100                 105                 110         


Val His Leu Ser Lys Ser Arg Thr Asp Tyr Gln Pro Thr Gln Ala Gly 
        115                 120                 125             


Arg Leu Met Arg Pro Ser Val Lys Tyr Leu Ser His Pro Arg Val Gln 
    130                 135                 140                 


Ser Gly Cys Asp Lys Glu Ala Leu Leu Thr Gly Gly Gly Ser Glu Asn 
145                 150                 155                 160 


Arg Asn His Arg Leu Leu Asn Met Ala Arg Asn Asn Asn Asp Pro Gly 
                165                 170                 175     


Arg Leu Thr Glu Ala Leu Cys Leu Glu Val Arg Pro Thr Tyr Phe Glu 
            180                 185                 190         


Met Lys Asn Glu Lys Leu Leu Ser Lys Ala Ser Glu Pro Lys Tyr Gln 
        195                 200                 205             


Leu Phe Val Pro Gln Leu Val Thr Gly Arg Cys Ala Thr Arg Ala Phe 
    210                 215                 220                 


His Arg Lys Ser His Ser Leu Asp Leu Asn Ile Ser Glu Lys Leu Thr 
225                 230                 235                 240 


Leu Leu Pro Thr Leu Tyr Glu Ile His Ser Lys Thr Thr Ala Tyr Ser 
                245                 250                 255     


Arg Leu Asn Glu Thr Gln Pro Ile Asp Leu Ser Gly Leu Pro Leu Gln 
            260                 265                 270         


Ser Ser Lys Asn Ser Tyr Ser Phe Gln Asn Pro Ser Ser Phe Asp Pro 
        275                 280                 285             


Ser Met Leu Leu Gln Arg Phe Ser Val Ala Pro His Glu Thr Gln Thr 
    290                 295                 300                 


Gln Arg Gly Gly Glu Phe Gln Cys Gly Leu Glu Ala Ala Ser Val Tyr 
305                 310                 315                 320 


Ser Asp His Thr Asn Thr Asn Asn Leu Thr Phe Leu Met Asp Leu Pro 
                325                 330                 335     


Ser Ala Gly Arg Ser Met Pro Glu Ala Ser Asp Gln Glu Glu His Leu 
            340                 345                 350         


Ser Pro Leu Asp Phe Leu His Ser Ala Asn Phe Ser Leu Gly Ser Ile 
        355                 360                 365             


Asn Gln Arg Leu Asn Lys Arg Glu Arg Ser Lys Leu Lys Asn Leu Arg 
    370                 375                 380                 


Arg Lys Gln Arg Arg Arg Glu Arg Trp Leu Gln Lys Gln Gly Lys Tyr 
385                 390                 395                 400 


Ser Gly Val Gly Leu Leu Asp His Met Val Ser Ile Tyr Leu Leu Ile 
                405                 410                 415     


<210>  6551
<211>  1039
<212>  PRT
<213>  Homo sapiens

<400>  6551

Met Pro Arg Leu Pro Val Lys Lys Ile Arg Lys Gln Met Lys Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ser Cys Ala Ala Trp Leu Thr Tyr Val His 
            20                  25                  30          


Leu Gly Leu Val Arg Gln Gly Arg Ala Leu Arg Gln Arg Leu Gly Tyr 
        35                  40                  45              


Gly Arg Asp Gly Glu Lys Leu Thr Ser Glu Thr Asp Gly Arg Gly Val 
    50                  55                  60                  


His Ala Ala Pro Ser Thr Gln Arg Ala Glu Asp Ser Ser Glu Ser Arg 
65                  70                  75                  80  


Glu Glu Glu Gln Ala Pro Glu Gly Arg Asp Leu Asp Met Leu Phe Pro 
                85                  90                  95      


Gly Gly Ala Gly Arg Leu Pro Leu Asn Phe Thr His Gln Thr Pro Pro 
            100                 105                 110         


Trp Arg Glu Glu Tyr Lys Gly Gln Val Asn Leu His Val Phe Glu Asp 
        115                 120                 125             


Trp Cys Gly Gly Ala Val Gly His Leu Arg Arg Asn Leu His Phe Pro 
    130                 135                 140                 


Leu Phe Pro His Thr Arg Thr Thr Val Lys Lys Leu Ala Val Ser Pro 
145                 150                 155                 160 


Lys Trp Lys Asn Tyr Gly Leu Arg Ile Phe Gly Phe Ile His Pro Ala 
                165                 170                 175     


Arg Asp Gly Asp Val Gln Phe Ser Val Ala Ser Asp Asp Asn Ser Glu 
            180                 185                 190         


Phe Trp Leu Ser Leu Asp Glu Ser Pro Ala Ala Ala Gln Leu Val Ala 
        195                 200                 205             


Phe Val Gly Lys Thr Gly Ser Glu Trp Thr Ala Pro Gly Glu Phe Thr 
    210                 215                 220                 


Lys Phe Ser Ser Gln Val Ser Lys Pro Arg Arg Leu Met Ala Ser Arg 
225                 230                 235                 240 


Arg Tyr Tyr Phe Glu Leu Leu His Lys Gln Asp Asp Arg Gly Ser Asp 
                245                 250                 255     


His Val Glu Val Gly Trp Arg Ala Phe Leu Pro Gly Leu Lys Phe Glu 
            260                 265                 270         


Val Ile Ser Ser Ala His Ile Ser Leu Tyr Thr Asp Glu Ser Ala Leu 
        275                 280                 285             


Lys Met Asp His Val Ala His Val Pro Gln Ser Pro Ala Ser His Val 
    290                 295                 300                 


Gly Gly Arg Pro Pro Gln Glu Glu Thr Ser Ala Asp Met Leu Arg Pro 
305                 310                 315                 320 


Asp Pro Arg Asp Thr Phe Phe Leu Thr Pro Arg Met Glu Ser Ser Ser 
                325                 330                 335     


Leu Glu Asn Val Leu Glu Pro Cys Ala Tyr Ala Pro Thr Tyr Val Val 
            340                 345                 350         


Lys Asp Phe Pro Ile Ala Arg Tyr Gln Gly Leu Gln Phe Val Tyr Leu 
        355                 360                 365             


Ser Phe Val Tyr Pro Asn Asp Tyr Thr Arg Leu Thr His Met Glu Thr 
    370                 375                 380                 


Asp Asn Lys Cys Phe Tyr Arg Glu Ser Pro Leu Tyr Leu Glu Arg Phe 
385                 390                 395                 400 


Gly Phe Tyr Lys Tyr Met Lys Met Asp Lys Glu Glu Gly Asp Glu Asp 
                405                 410                 415     


Glu Glu Asp Glu Val Gln Arg Arg Ala Phe Leu Phe Leu Asn Pro Asp 
            420                 425                 430         


Asp Phe Leu Asp Asp Glu Asp Glu Gly Glu Leu Leu Asp Ser Leu Glu 
        435                 440                 445             


Pro Thr Glu Ala Ala Pro Pro Arg Ser Gly Pro Gln Ser Pro Ala Pro 
    450                 455                 460                 


Ala Ala Pro Ala Gln Pro Gly Ala Thr Leu Ala Pro Pro Thr Pro Pro 
465                 470                 475                 480 


Arg Pro Arg Asp Gly Gly Thr Pro Arg His Ser Arg Ala Leu Ser Trp 
                485                 490                 495     


Ala Ala Arg Ala Ala Arg Pro Leu Pro Leu Phe Leu Gly Arg Ala Pro 
            500                 505                 510         


Pro Pro Arg Pro Ala Val Glu Gln Pro Pro Pro Lys Val Tyr Val Thr 
        515                 520                 525             


Arg Val Arg Pro Gly Gln Arg Ala Ser Pro Arg Ala Pro Ala Pro Arg 
    530                 535                 540                 


Ala Pro Trp Pro Pro Phe Pro Gly Val Phe Leu His Pro Arg Pro Leu 
545                 550                 555                 560 


Pro Arg Val Gln Leu Arg Ala Pro Pro Arg Pro Pro Arg Pro His Gly 
                565                 570                 575     


Arg Arg Thr Gly Gly Pro Gln Ala Thr Gln Pro Arg Pro Pro Ala Arg 
            580                 585                 590         


Ala Gln Ala Thr Gln Gly Gly Arg Glu Gly Gln Ala Arg Thr Leu Gly 
        595                 600                 605             


Pro Ala Ala Pro Thr Val Asp Ser Asn Leu Ser Ser Glu Ala Arg Pro 
    610                 615                 620                 


Val Thr Ser Phe Leu Ser Leu Ser Gln Val Ser Gly Pro Gln Leu Pro 
625                 630                 635                 640 


Gly Glu Gly Glu Glu Glu Glu Glu Gly Glu Asp Asp Gly Ala Pro Gly 
                645                 650                 655     


Asp Glu Ala Ala Ser Glu Asp Ser Glu Glu Ala Ala Gly Pro Ala Leu 
            660                 665                 670         


Gly Arg Trp Arg Glu Asp Ala Ile Asp Trp Gln Arg Thr Phe Ser Val 
        675                 680                 685             


Gly Ala Val Asp Phe Glu Leu Leu Arg Ser Asp Trp Asn Asp Leu Arg 
    690                 695                 700                 


Cys Asn Val Ser Gly Asn Leu Gln Leu Pro Glu Ala Glu Ala Val Asp 
705                 710                 715                 720 


Val Thr Ala Gln Tyr Met Glu Arg Leu Asn Ala Arg His Gly Gly Arg 
                725                 730                 735     


Phe Ala Leu Leu Arg Ile Val Asn Val Glu Lys Arg Arg Asp Ser Ala 
            740                 745                 750         


Arg Gly Ser Arg Phe Leu Leu Glu Leu Glu Leu Gln Glu Arg Gly Gly 
        755                 760                 765             


Gly Arg Leu Arg Leu Ser Glu Tyr Val Phe Leu Arg Leu Pro Gly Ala 
    770                 775                 780                 


Arg Val Gly Asp Ala Asp Gly Glu Ser Pro Glu Pro Ala Pro Ala Ala 
785                 790                 795                 800 


Ser Val Arg Pro Asp Gly Arg Pro Glu Leu Cys Arg Pro Leu Arg Leu 
                805                 810                 815     


Ala Trp Arg Gln Asp Val Met Val His Phe Ile Val Pro Val Lys Asn 
            820                 825                 830         


Gln Ala Arg Trp Val Ala Gln Phe Leu Ala Asp Met Ala Ala Leu His 
        835                 840                 845             


Ala Arg Thr Gly Asp Ser Arg Phe Ser Val Val Leu Val Asp Phe Glu 
    850                 855                 860                 


Ser Glu Asp Met Asp Val Glu Arg Ala Leu Arg Ala Ala Arg Leu Pro 
865                 870                 875                 880 


Arg Tyr Gln Tyr Leu Arg Arg Thr Gly Asn Phe Glu Arg Ser Ala Gly 
                885                 890                 895     


Leu Gln Ala Gly Val Asp Ala Val Glu Asp Ala Ser Ser Ile Val Phe 
            900                 905                 910         


Leu Cys Asp Leu His Ile His Phe Pro Pro Asn Ile Leu Asp Gly Ile 
        915                 920                 925             


Arg Lys His Cys Val Glu Gly Arg Leu Ala Phe Ala Pro Val Val Met 
    930                 935                 940                 


Arg Leu Ser Cys Gly Ser Ser Pro Arg Asp Pro His Gly Tyr Trp Glu 
945                 950                 955                 960 


Val Asn Gly Phe Gly Leu Phe Gly Ile Tyr Lys Ser Asp Phe Asp Arg 
                965                 970                 975     


Val Gly Gly Met Asn Thr Glu Glu Phe Arg Asp Gln Trp Gly Gly Glu 
            980                 985                 990         


Asp Trp Glu Leu Leu Asp Arg Val  Leu Gln Ala Gly Leu  Glu Val Glu 
        995                 1000                 1005             


Arg Leu  Arg Leu Arg Asn Phe  Tyr His His Tyr His  Ser Lys Arg 
    1010                 1015                 1020             


Gly Met  Trp Ser Val Arg Ser  Arg Lys Gly Ser Arg  Thr Gly Ala 
    1025                 1030                 1035             


Ser 
    


<210>  6552
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  6552

Met Ser Lys Arg Tyr Leu Gln Lys Ala Thr Lys Gly Lys Leu Leu Ile 
1               5                   10                  15      


Ile Ile Phe Ile Val Thr Leu Trp Gly Lys Val Val Ser Ser Ala Asn 
            20                  25                  30          


His His Lys Ala His His Val Lys Thr Gly Thr Cys Glu Val Val Ala 
        35                  40                  45              


Leu His Arg Cys Cys Asn Lys Asn Lys Ile Glu Glu Arg Ser Gln Thr 
    50                  55                  60                  


Val Lys Cys Ser Cys Phe Pro Gly Gln Val Ala Gly Thr Thr Arg Ala 
65                  70                  75                  80  


Ala Pro Ser Cys Val Asp Ala Ser Ile Val Glu Gln Lys Trp Trp Cys 
                85                  90                  95      


His Met Gln Pro Cys Leu Glu Gly Glu Glu Cys Lys Val Leu Pro Asp 
            100                 105                 110         


Arg Lys Gly Trp Ser Cys Ser Ser Gly Asn Lys Val Lys Thr Thr Arg 
        115                 120                 125             


Val Thr His 
    130     


<210>  6553
<211>  836
<212>  PRT
<213>  Homo sapiens

<400>  6553

Met Gln Val Asp Pro Pro Leu His Gly Pro Pro Asn Asp Phe Leu Ile 
1               5                   10                  15      


Phe Gln Ile Ile Pro Leu His Ser Leu Ser Ile Met Pro Arg Phe Leu 
            20                  25                  30          


Trp Ile Leu Cys Phe Ser Met Glu Glu Thr Gln Gly Glu Leu Thr Ser 
        35                  40                  45              


Ser Cys Gly Ser Lys Thr Met Ala Asn Val Ser Leu Ala Phe Arg Asp 
    50                  55                  60                  


Val Ser Ile Asp Leu Ser Gln Glu Glu Trp Glu Cys Leu Asp Ala Val 
65                  70                  75                  80  


Gln Arg Asp Leu Tyr Lys Asp Val Met Leu Glu Asn Tyr Ser Asn Leu 
                85                  90                  95      


Val Ser Leu Gly Tyr Thr Ile Pro Lys Pro Asp Val Ile Thr Leu Leu 
            100                 105                 110         


Glu Gln Glu Lys Glu Pro Trp Ile Val Met Arg Glu Gly Thr Arg Asn 
        115                 120                 125             


Trp Phe Thr Asp Leu Glu Tyr Lys Tyr Ile Thr Lys Asn Leu Leu Ser 
    130                 135                 140                 


Glu Lys Asn Val Cys Lys Ile Tyr Leu Ser Gln Leu Gln Thr Gly Glu 
145                 150                 155                 160 


Lys Ser Lys Asn Thr Ile His Glu Asp Thr Ile Phe Arg Asn Gly Leu 
                165                 170                 175     


Gln Cys Lys His Glu Phe Glu Arg Gln Glu Arg His Gln Met Gly Cys 
            180                 185                 190         


Val Ser Gln Met Leu Ile Gln Lys Gln Ile Ser His Pro Leu His Pro 
        195                 200                 205             


Lys Ile His Ala Arg Glu Lys Ser Tyr Glu Cys Lys Glu Cys Arg Lys 
    210                 215                 220                 


Ala Phe Arg Gln Gln Ser Tyr Leu Ile Gln His Leu Arg Ile His Thr 
225                 230                 235                 240 


Gly Glu Arg Pro Tyr Lys Cys Met Glu Cys Gly Lys Ala Phe Cys Arg 
                245                 250                 255     


Val Gly Asp Leu Arg Val His His Thr Ile His Ala Gly Glu Arg Pro 
            260                 265                 270         


Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Arg Leu His Tyr His Leu 
        275                 280                 285             


Thr Glu His Gln Arg Ile His Ser Gly Val Lys Pro Tyr Glu Cys Lys 
    290                 295                 300                 


Glu Cys Gly Lys Ala Phe Ser Arg Val Arg Asp Leu Arg Val His Gln 
305                 310                 315                 320 


Thr Ile His Ala Gly Glu Arg Pro Tyr Glu Cys Lys Glu Cys Gly Lys 
                325                 330                 335     


Ala Phe Arg Leu His Tyr Gln Leu Thr Glu His Gln Arg Ile His Thr 
            340                 345                 350         


Gly Glu Arg Pro Tyr Glu Cys Lys Val Cys Gly Lys Thr Phe Arg Val 
        355                 360                 365             


Gln Arg His Ile Ser Gln His Gln Lys Ile His Thr Gly Val Lys Pro 
    370                 375                 380                 


Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Ser His Gly Ser Tyr Leu 
385                 390                 395                 400 


Val Gln His Gln Lys Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys 
                405                 410                 415     


Glu Cys Gly Lys Ser Phe Ser Phe His Ala Glu Leu Ala Arg His Arg 
            420                 425                 430         


Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Arg Glu Cys Gly Lys 
        435                 440                 445             


Ala Phe Arg Leu Gln Thr Glu Leu Thr Arg His His Arg Thr His Thr 
    450                 455                 460                 


Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Ile Cys 
465                 470                 475                 480 


Gly Tyr Gln Leu Thr Leu His Leu Arg Thr His Thr Gly Glu Ile Pro 
                485                 490                 495     


Tyr Glu Cys Lys Glu Cys Gly Lys Thr Phe Ser Ser Arg Tyr His Leu 
            500                 505                 510         


Thr Gln His Tyr Arg Ile His Thr Gly Glu Lys Pro Tyr Ile Cys Asn 
        515                 520                 525             


Glu Cys Gly Lys Ala Phe Arg Leu Gln Gly Glu Leu Thr Arg His His 
    530                 535                 540                 


Arg Ile His Thr Cys Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys 
545                 550                 555                 560 


Ala Phe Ile His Ser Asn Gln Phe Ile Ser His Gln Arg Ile His Thr 
                565                 570                 575     


Ser Glu Ser Thr Tyr Ile Cys Lys Glu Cys Gly Lys Ile Phe Ser Arg 
            580                 585                 590         


Arg Tyr Asn Leu Thr Gln His Phe Lys Ile His Thr Gly Glu Lys Pro 
        595                 600                 605             


Tyr Ile Cys Asn Glu Cys Gly Lys Ala Phe Arg Phe Gln Thr Glu Leu 
    610                 615                 620                 


Thr Gln His His Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Thr 
625                 630                 635                 640 


Glu Cys Gly Lys Ala Phe Ile Arg Ser Thr His Leu Thr Gln His His 
                645                 650                 655     


Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Thr Glu Cys Gly Lys 
            660                 665                 670         


Thr Phe Ser Arg His Tyr His Leu Thr Gln His His Arg Gly His Thr 
        675                 680                 685             


Gly Glu Lys Pro Tyr Ile Cys Asn Glu Cys Gly Asn Ala Phe Ile Cys 
    690                 695                 700                 


Ser Tyr Arg Leu Thr Leu His Gln Arg Ile His Thr Gly Glu Leu Pro 
705                 710                 715                 720 


Tyr Glu Cys Lys Glu Cys Gly Lys Thr Phe Ser Arg Arg Tyr His Leu 
                725                 730                 735     


Thr Gln His Phe Arg Leu His Thr Gly Glu Lys Pro Tyr Ser Cys Lys 
            740                 745                 750         


Glu Cys Gly Asn Ala Phe Arg Leu Gln Ala Glu Leu Thr Arg His His 
        755                 760                 765             


Ile Val His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys 
    770                 775                 780                 


Ala Phe Ser Val Asn Ser Glu Leu Thr Arg His His Arg Ile His Thr 
785                 790                 795                 800 


Gly Glu Lys Pro Tyr Gln Cys Lys Glu Cys Gly Lys Ala Phe Ile Arg 
                805                 810                 815     


Ser Asp Gln Leu Thr Leu His Gln Arg Asn His Ile Ser Glu Glu Val 
            820                 825                 830         


Leu Cys Ile Met 
        835     


<210>  6554
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  6554

Met Ala Arg Gly Pro Leu Ala Ala Arg Gly Leu Arg Leu Leu Leu Pro 
1               5                   10                  15      


Leu Leu Pro Leu Leu Pro Leu Leu Pro Leu Pro Gln Val Ala Leu Gly 
            20                  25                  30          


Phe Ala Asp Gly Ser Cys Asp Pro Ser Asp Gln Cys Pro Pro Gln Ala 
        35                  40                  45              


Arg Trp Ser Ser Leu Trp His Val Gly Leu Ile Leu Leu Ala Val Leu 
    50                  55                  60                  


Leu Leu Leu Leu Cys Gly Val Thr Ala Gly Cys Val Arg Phe Cys Cys 
65                  70                  75                  80  


Leu Arg Lys Gln Ala Gln Ala Gln Pro His Leu Pro Pro Ala Arg Gln 
                85                  90                  95      


Pro Cys Asp Val Ala Val Ile Pro Met Asp Ser Asp Ser Pro Val His 
            100                 105                 110         


Ser Thr Val Thr Ser Tyr Ser Ser Val Gln Tyr Pro Leu Gly Met Arg 
        115                 120                 125             


Leu Pro Leu Pro Phe Gly Glu Leu Asp Leu Asp Ser Met Ala Pro Pro 
    130                 135                 140                 


Ala Tyr Ser Leu Tyr Thr Pro Glu Pro Pro Pro Ser Tyr Asp Glu Ala 
145                 150                 155                 160 


Val Lys Met Ala Lys Pro Arg Glu Glu Gly Pro Ala Leu Ser Gln Lys 
                165                 170                 175     


Pro Ser Pro Leu Leu Gly Ala Ser Gly Leu Glu Thr Thr Pro Val Pro 
            180                 185                 190         


Gln Glu Ser Gly Pro Asn Thr Gln Leu Pro Pro Cys Ser Pro Gly Ala 
        195                 200                 205             


Pro 
    


<210>  6555
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  6555

Met His Cys Gly Pro Pro Asp Met Val Cys Glu Thr Lys Ile Val Ala 
1               5                   10                  15      


Ala Glu Asp His Glu Ala Leu Pro Gly Ala Lys Lys Asp Ala Leu Leu 
            20                  25                  30          


Ala Ala Ala Gly Ala Met Trp Pro Pro Leu Pro Ala Ala Pro Gly Pro 
        35                  40                  45              


Ala Ala Ala Pro Pro Ala Pro Pro Pro Ala Pro Val Ala Gln Pro His 
    50                  55                  60                  


Gly Gly Ala Gly Gly Ala Gly Pro Pro Gly Gly Arg Gly Val Cys Ile 
65                  70                  75                  80  


Arg Glu Phe Arg Ala Ala Glu Gln Glu Ala Ala Arg Arg Ile Phe Tyr 
                85                  90                  95      


Asp Gly Ile Met Glu Arg Ile Pro Asn Thr Ala Phe Arg Gly Leu Arg 
            100                 105                 110         


Gln His Pro Arg Ala Gln Leu Leu Tyr Ala Leu Leu Ala Ala Leu Cys 
        115                 120                 125             


Phe Ala Val Ser Arg Ser Leu Leu Leu Thr Cys Leu Val Pro Ala Ala 
    130                 135                 140                 


Leu Leu Gly Leu Arg Tyr Tyr Tyr Ser Arg Lys Val Ile Arg Ala Tyr 
145                 150                 155                 160 


Leu Glu Cys Ala Leu His Thr Asp Met Ala Asp Ile Glu Gln Tyr Tyr 
                165                 170                 175     


Met Lys Pro Pro Gly Ser Cys Phe Trp Val Ala Val Leu Asp Gly Asn 
            180                 185                 190         


Val Val Gly Ile Val Ala Ala Arg Ala His Glu Glu Asp Asn Thr Val 
        195                 200                 205             


Glu Leu Leu Arg Met Ser Val Asp Ser Arg Phe Arg Gly Lys Gly Ile 
    210                 215                 220                 


Ala Lys Ala Leu Gly Arg Lys Val Leu Glu Phe Ala Val Val His Asn 
225                 230                 235                 240 


Tyr Ser Ala Val Val Leu Gly Thr Thr Ala Val Lys Val Ala Ala His 
                245                 250                 255     


Lys Leu Tyr Glu Ser Leu Gly Phe Arg His Met Gly Ala Ser Asp His 
            260                 265                 270         


Tyr Val Leu Pro Gly Met Thr Leu Ser Leu Ala Glu Arg Leu Phe Phe 
        275                 280                 285             


Gln Val Arg Tyr His Arg Tyr Arg Leu Gln Leu Arg Glu Glu 
    290                 295                 300         


<210>  6556
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  6556

Met Ala Arg Arg Pro Arg Ala Pro Ala Ala Ser Gly Glu Glu Phe Ser 
1               5                   10                  15      


Phe Val Ser Pro Leu Val Lys Tyr Leu Leu Phe Phe Phe Asn Met Leu 
            20                  25                  30          


Phe Trp Val Ile Ser Met Val Met Val Ala Val Gly Val Tyr Ala Arg 
        35                  40                  45              


Leu Met Lys His Ala Glu Ala Ala Leu Ala Cys Leu Ala Val Asp Pro 
    50                  55                  60                  


Ala Ile Leu Leu Ile Val Val Gly Val Leu Met Phe Leu Leu Thr Phe 
65                  70                  75                  80  


Cys Gly Cys Ile Gly Ser Leu Arg Glu Asn Ile Cys Leu Leu Gln Thr 
                85                  90                  95      


Phe Ser Leu Cys Leu Thr Ala Val Phe Leu Leu Gln Leu Ala Ala Gly 
            100                 105                 110         


Ile Leu Gly Phe Val Phe Ser Asp Lys Ala Arg Gly Lys Val Ser Glu 
        115                 120                 125             


Ile Ile Asn Asn Ala Ile Val His Tyr Arg Asp Asp Leu Asp Leu Gln 
    130                 135                 140                 


Asn Leu Ile Asp Phe Gly Gln Lys Lys Phe Ser Cys Cys Gly Gly Ile 
145                 150                 155                 160 


Ser Tyr Lys Asp Trp Ser Gln Asn Met Tyr Phe Asn Cys Ser Glu Asp 
                165                 170                 175     


Asn Pro Ser Arg Glu Arg Cys Ser Val Pro Tyr Ser Cys Cys Leu Pro 
            180                 185                 190         


Thr Pro Asp Gln Ala Val Ile Asn Thr Met Cys Gly Gln Gly Met Gln 
        195                 200                 205             


Ala Phe Asp Tyr Leu Glu Ala Ser Lys Val Ile Tyr Thr Asn Gly Cys 
    210                 215                 220                 


Ile Asp Lys Leu Val Asn Trp Ile His Ser Asn Leu Phe Leu Leu Gly 
225                 230                 235                 240 


Gly Val Ala Leu Gly Leu Ala Ile Pro Gln Leu Val Gly Ile Leu Leu 
                245                 250                 255     


Ser Gln Ile Leu Val Asn Gln Ile Lys Asp Gln Ile Lys Leu Gln Leu 
            260                 265                 270         


Tyr Asn Gln Gln His Arg Ala Asp Pro Trp Tyr 
        275                 280             


<210>  6557
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  6557

Met Gly Leu Arg Ile His Phe Val Val Asp Pro His Gly Trp Cys Cys 
1               5                   10                  15      


Met Gly Leu Ile Val Phe Val Trp Leu Tyr Asn Ile Val Leu Ile Pro 
            20                  25                  30          


Lys Ile Val Leu Phe Pro His Tyr Glu Glu Gly His Ile Pro Gly Ile 
        35                  40                  45              


Leu Ile Ile Ile Phe Tyr Gly Ile Ser Ile Phe Cys Leu Val Ala Leu 
    50                  55                  60                  


Val Arg Ala Ser Ile Thr Asp Pro Gly Arg Leu Pro Glu Asn Pro Lys 
65                  70                  75                  80  


Ile Pro His Gly Glu Arg Glu Phe Trp Glu Leu Cys Asn Lys Cys Asn 
                85                  90                  95      


Leu Met Arg Pro Lys Arg Ser His His Cys Ser Arg Cys Gly His Cys 
            100                 105                 110         


Val Arg Arg Met Asp His His Cys Pro Trp Ile Asn Asn Cys Val Gly 
        115                 120                 125             


Glu Asp Asn His Trp Leu Phe Leu Gln Leu Cys Phe Tyr Thr Glu Leu 
    130                 135                 140                 


Leu Thr Cys Tyr Ala Leu Met Phe Ser Phe Cys His Tyr Tyr Tyr Phe 
145                 150                 155                 160 


Leu Pro Leu Lys Lys Arg Asn Leu Asp Leu Phe Val Phe Arg His Glu 
                165                 170                 175     


Leu Ala Ile Met Arg Leu Ala Ala Phe Met Gly Ile Thr Met Leu Val 
            180                 185                 190         


Gly Ile Thr Gly Leu Phe Tyr Thr Gln Leu Ile Gly Ile Ile Thr Asp 
        195                 200                 205             


Thr Thr Ser Ile Glu Lys Met Ser Asn Cys Cys Glu Asp Ile Ser Arg 
    210                 215                 220                 


Pro Arg Lys Pro Trp Gln Gln Thr Phe Ser Glu Val Phe Gly Thr Arg 
225                 230                 235                 240 


Trp Lys Ile Leu Trp Phe Ile Pro Phe Arg Gln Arg Gln Pro Leu Arg 
                245                 250                 255     


Val Pro Tyr His Phe Ala Asn His Val 
            260                 265 


<210>  6558
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  6558

Met Asp Ser Ala Leu Ser Asp Pro His Asn Gly Ser Ala Glu Ala Gly 
1               5                   10                  15      


Gly Pro Thr Asn Ser Thr Thr Arg Pro Pro Ser Thr Pro Glu Gly Ile 
            20                  25                  30          


Ala Leu Ala Tyr Gly Ser Leu Leu Leu Met Ala Leu Leu Pro Ile Phe 
        35                  40                  45              


Phe Gly Ala Leu Arg Ser Val Arg Cys Ala Arg Gly Lys Asn Ala Ser 
    50                  55                  60                  


Asp Met Pro Glu Thr Ile Thr Ser Arg Asp Ala Ala Arg Phe Pro Ile 
65                  70                  75                  80  


Ile Ala Ser Cys Thr Leu Leu Gly Leu Tyr Leu Phe Phe Lys Ile Phe 
                85                  90                  95      


Ser Gln Glu Tyr Ile Asn Leu Leu Leu Ser Met Tyr Phe Phe Val Leu 
            100                 105                 110         


Gly Ile Leu Ala Leu Ser His Thr Ile Ser Pro Phe Met Asn Lys Phe 
        115                 120                 125             


Phe Pro Ala Ser Phe Pro Asn Arg Gln Tyr Gln Leu Leu Phe Thr Gln 
    130                 135                 140                 


Gly Ser Gly Glu Asn Lys Glu Glu Ile Ile Asn Tyr Glu Phe Asp Thr 
145                 150                 155                 160 


Lys Asp Leu Val Cys Leu Gly Leu Ser Ser Ile Val Gly Val Trp Tyr 
                165                 170                 175     


Leu Leu Arg Lys His Trp Ile Ala Asn Asn Leu Phe Gly Leu Ala Phe 
            180                 185                 190         


Ser Leu Asn Gly Val Glu Leu Leu His Leu Asn Asn Val Ser Thr Gly 
        195                 200                 205             


Cys Ile Leu Leu Gly Gly Leu Phe Ile Tyr Asp Val Phe Trp Val Phe 
    210                 215                 220                 


Gly Thr Asn Val Met Val Thr Val Ala Lys Ser Phe Glu Ala Pro Ile 
225                 230                 235                 240 


Lys Leu Val Phe Pro Gln Asp Leu Leu Glu Lys Gly Leu Glu Ala Asn 
                245                 250                 255     


Asn Phe Ala Met Leu Gly Leu Gly Asp Val Val Ile Pro Gly Ile Phe 
            260                 265                 270         


Ile Ala Leu Leu Leu Arg Phe Asp Ile Ser Leu Lys Lys Asn Thr His 
        275                 280                 285             


Thr Tyr Phe Tyr Thr Ser Phe Ala Ala Tyr Ile Phe Gly Leu Gly Leu 
    290                 295                 300                 


Thr Ile Phe Ile Met His Ile Phe Lys His Ala Gln Pro Ala Leu Leu 
305                 310                 315                 320 


Tyr Leu Val Pro Ala Cys Ile Gly Phe Pro Val Leu Val Ala Leu Ala 
                325                 330                 335     


Lys Gly Glu Val Thr Glu Met Phe Ser Tyr Glu Ser Ser Ala Glu Ile 
            340                 345                 350         


Leu Pro His Thr Pro Arg Leu Thr His Phe Pro Thr Val Ser Gly Ser 
        355                 360                 365             


Pro Ala Ser Leu Ala Asp Ser Met Gln Gln Lys Leu Ala Gly Pro Arg 
    370                 375                 380                 


Arg Arg Arg Pro Gln Asn Pro Ser Ala Met 
385                 390                 


<210>  6559
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  6559

Met Asp Ser Ala Leu Ser Asp Pro His Asn Gly Ser Ala Glu Ala Gly 
1               5                   10                  15      


Gly Pro Thr Asn Ser Thr Thr Arg Pro Pro Ser Thr Pro Glu Gly Ile 
            20                  25                  30          


Ala Leu Ala Tyr Gly Ser Leu Leu Leu Met Ala Leu Leu Pro Ile Phe 
        35                  40                  45              


Phe Gly Ala Leu Arg Ser Val Arg Cys Ala Arg Gly Lys Asn Ala Ser 
    50                  55                  60                  


Asp Met Pro Glu Thr Ile Thr Ser Arg Asp Ala Ala Arg Phe Pro Ile 
65                  70                  75                  80  


Ile Ala Ser Cys Thr Leu Leu Gly Leu Tyr Leu Phe Phe Lys Ile Phe 
                85                  90                  95      


Ser Gln Glu Tyr Ile Asn Leu Leu Leu Ser Met Tyr Phe Phe Val Leu 
            100                 105                 110         


Gly Ile Leu Ala Leu Ser His Thr Ile Ser Pro Phe Met Asn Lys Phe 
        115                 120                 125             


Phe Pro Ala Ser Phe Pro Asn Arg Gln Tyr Gln Leu Leu Phe Thr Gln 
    130                 135                 140                 


Gly Ser Gly Glu Asn Lys Glu Glu Ile Ile Asn Tyr Glu Phe Asp Thr 
145                 150                 155                 160 


Lys Asp Leu Val Cys Leu Gly Leu Ser Ser Ile Val Gly Val Trp Tyr 
                165                 170                 175     


Leu Leu Arg Lys His Trp Ile Ala Asn Asn Leu Phe Gly Leu Ala Phe 
            180                 185                 190         


Ser Leu Asn Gly Val Glu Leu Leu His Leu Asn Asn Val Ser Thr Gly 
        195                 200                 205             


Cys Ile Leu Leu Gly Gly Leu Phe Ile Tyr Asp Val Phe Trp Val Phe 
    210                 215                 220                 


Gly Thr Asn Val Met Val Thr Val Ala Lys Ser Phe Glu Ala Pro Ile 
225                 230                 235                 240 


Lys Leu Val Phe Pro Gln Asp Leu Leu Glu Lys Gly Leu Glu Ala Asn 
                245                 250                 255     


Asn Phe Ala Met Leu Gly Leu Gly Asp Val Val Ile Pro Gly Ile Phe 
            260                 265                 270         


Ile Ala Leu Leu Leu Arg Phe Asp Ile Ser Leu Lys Lys Asn Thr His 
        275                 280                 285             


Thr Tyr Phe Tyr Thr Ser Phe Ala Ala Tyr Ile Phe Gly Leu Gly Leu 
    290                 295                 300                 


Thr Ile Phe Ile Met His Ile Phe Lys His Ala Gln Pro Ala Leu Leu 
305                 310                 315                 320 


Tyr Leu Val Pro Ala Cys Ile Gly Phe Pro Val Leu Val Ala Leu Ala 
                325                 330                 335     


Lys Gly Glu Val Thr Glu Met Phe Ser Tyr Glu Ser Ser Ala Glu Ile 
            340                 345                 350         


Leu Pro His Thr Pro Arg Leu Thr His Phe Pro Thr Val Ser Gly Ser 
        355                 360                 365             


Pro Ala Ser Leu Ala Asp Ser Met Gln Gln Lys Leu Ala Gly Pro Arg 
    370                 375                 380                 


Arg Arg Arg Pro Gln Asn Pro Ser Ala Ile Tyr Glu Glu Ser Asn Pro 
385                 390                 395                 400 


Lys Asp Pro Ala Ala Val Thr Glu Ser Lys Glu Gly Thr Glu Ala Ser 
                405                 410                 415     


Ala Ser Lys Gly Leu Glu Lys Lys Glu Lys 
            420                 425     


<210>  6560
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  6560

Met Asp Ser Ala Leu Ser Asp Pro His Asn Gly Ser Ala Glu Ala Gly 
1               5                   10                  15      


Gly Pro Thr Asn Ser Thr Thr Arg Pro Pro Ser Thr Pro Glu Gly Ile 
            20                  25                  30          


Ala Leu Ala Tyr Gly Ser Leu Leu Leu Met Ala Leu Leu Pro Ile Phe 
        35                  40                  45              


Phe Gly Ala Leu Arg Ser Val Arg Cys Ala Arg Gly Lys Asn Ala Ser 
    50                  55                  60                  


Asp Met Pro Glu Thr Ile Thr Ser Arg Asp Ala Ala Arg Phe Pro Ile 
65                  70                  75                  80  


Ile Ala Ser Cys Thr Leu Leu Gly Leu Tyr Leu Phe Phe Lys Ile Phe 
                85                  90                  95      


Ser Gln Glu Tyr Ile Asn Leu Leu Leu Ser Met Tyr Phe Phe Val Leu 
            100                 105                 110         


Gly Ile Leu Ala Leu Ser His Thr Ile Arg Ser Glu Gly Ile Ser Leu 
        115                 120                 125             


Gln His Leu Lys Gln Leu Ser Arg Glu Pro Val Gln Gly Leu Gly 
    130                 135                 140             


<210>  6561
<211>  582
<212>  PRT
<213>  Homo sapiens

<400>  6561

Met Ala Ala Arg Ser Trp Gln Asp Glu Leu Ala Gln Gln Ala Glu Glu 
1               5                   10                  15      


Gly Ser Ala Arg Leu Arg Glu Met Leu Ser Val Gly Leu Gly Phe Leu 
            20                  25                  30          


Arg Thr Glu Leu Gly Leu Asp Leu Gly Leu Glu Pro Lys Arg Tyr Pro 
        35                  40                  45              


Gly Trp Val Ile Leu Val Gly Thr Gly Ala Leu Gly Leu Leu Leu Leu 
    50                  55                  60                  


Phe Leu Leu Gly Tyr Gly Trp Ala Ala Ala Cys Ala Gly Ala Arg Lys 
65                  70                  75                  80  


Lys Arg Arg Ser Pro Pro Arg Lys Arg Glu Glu Ala Ala Ala Val Pro 
                85                  90                  95      


Ala Ala Ala Pro Asp Asp Leu Ala Leu Leu Lys Asn Leu Arg Ser Glu 
            100                 105                 110         


Glu Gln Lys Lys Lys Asn Arg Lys Lys Leu Ser Glu Lys Pro Lys Pro 
        115                 120                 125             


Asn Gly Arg Thr Val Glu Val Ala Glu Gly Glu Ala Val Arg Thr Pro 
    130                 135                 140                 


Gln Ser Val Thr Ala Lys Gln Pro Pro Glu Ile Asp Lys Lys Asn Glu 
145                 150                 155                 160 


Lys Ser Lys Lys Asn Lys Lys Lys Ser Lys Ser Asp Ala Lys Ala Val 
                165                 170                 175     


Gln Asn Ser Ser Arg His Asp Gly Lys Glu Val Asp Glu Gly Ala Trp 
            180                 185                 190         


Glu Thr Lys Ile Ser His Arg Glu Lys Arg Gln Gln Arg Lys Arg Asp 
        195                 200                 205             


Lys Val Leu Thr Asp Ser Gly Ser Leu Asp Ser Thr Ile Pro Gly Ile 
    210                 215                 220                 


Glu Asn Thr Ile Thr Val Thr Thr Glu Gln Leu Thr Thr Ala Ser Phe 
225                 230                 235                 240 


Pro Val Gly Ser Lys Lys Asn Lys Gly Asp Ser His Leu Asn Val Gln 
                245                 250                 255     


Val Ser Asn Phe Lys Ser Gly Lys Gly Asp Ser Thr Leu Gln Val Ser 
            260                 265                 270         


Ser Gly Leu Asn Glu Asn Leu Thr Val Asn Gly Gly Gly Trp Asn Glu 
        275                 280                 285             


Lys Ser Val Lys Leu Ser Ser Gln Ile Ser Ala Gly Glu Glu Lys Trp 
    290                 295                 300                 


Asn Ser Val Ser Pro Ala Ser Ala Gly Lys Arg Lys Thr Glu Pro Ser 
305                 310                 315                 320 


Ala Trp Ser Gln Asp Thr Gly Asp Ala Asn Thr Asn Gly Lys Asp Trp 
                325                 330                 335     


Gly Arg Ser Trp Ser Asp Arg Ser Ile Phe Ser Gly Ile Gly Ser Thr 
            340                 345                 350         


Ala Glu Pro Val Ser Gln Ser Thr Thr Ser Asp Tyr Gln Trp Asp Val 
        355                 360                 365             


Ser Arg Asn Gln Pro Tyr Ile Asp Asp Glu Trp Ser Gly Leu Asn Gly 
    370                 375                 380                 


Leu Ser Ser Ala Asp Pro Asn Ser Asp Trp Asn Ala Pro Ala Glu Glu 
385                 390                 395                 400 


Trp Gly Asn Trp Val Asp Glu Glu Arg Ala Ser Leu Leu Lys Ser Gln 
                405                 410                 415     


Glu Pro Ile Pro Asp Asp Gln Lys Val Ser Asp Asp Asp Lys Glu Lys 
            420                 425                 430         


Gly Glu Gly Ala Leu Pro Thr Gly Lys Ser Lys Lys Lys Lys Lys Lys 
        435                 440                 445             


Lys Lys Lys Gln Gly Glu Asp Asn Ser Thr Ala Gln Asp Thr Glu Glu 
    450                 455                 460                 


Leu Glu Lys Glu Ile Arg Glu Asp Leu Pro Val Asn Thr Ser Lys Thr 
465                 470                 475                 480 


Arg Pro Lys Gln Glu Lys Ala Phe Ser Leu Lys Thr Ile Ser Thr Ser 
                485                 490                 495     


Asp Pro Ala Glu Val Leu Val Lys Asn Ser Gln Pro Ile Lys Thr Leu 
            500                 505                 510         


Pro Pro Ala Thr Ser Thr Glu Pro Ser Val Ile Leu Ser Lys Ser Asp 
        515                 520                 525             


Ser Asp Lys Ser Ser Ser Gln Val Pro Pro Ile Leu Gln Glu Thr Asp 
    530                 535                 540                 


Lys Ser Lys Ser Asn Thr Lys Gln Asn Ser Val Pro Pro Ser Gln Thr 
545                 550                 555                 560 


Lys Ser Glu Thr Ser Trp Glu Ser Pro Lys Gln Ile Lys Lys Lys Lys 
                565                 570                 575     


Lys Ala Arg Arg Glu Thr 
            580         


<210>  6562
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  6562

Met Ala Asn Gly Thr Asn Ala Ser Ala Pro Tyr Tyr Ser Tyr Glu Tyr 
1               5                   10                  15      


Tyr Leu Asp Tyr Leu Asp Leu Ile Pro Val Asp Glu Lys Lys Leu Lys 
            20                  25                  30          


Ala His Lys His Ser Ile Val Ile Ala Phe Trp Val Ser Leu Ala Ala 
        35                  40                  45              


Phe Val Val Leu Leu Phe Leu Ile Leu Leu Tyr Met Ser Trp Ser Ala 
    50                  55                  60                  


Ser Pro Gln Met Arg Asn Ser Pro Lys His His Gln Thr Cys Pro Trp 
65                  70                  75                  80  


Ser His Gly Leu Asn Leu His Leu Cys Ile Gln Lys Cys Leu Pro Cys 
                85                  90                  95      


His Arg Glu Pro Leu Ala Thr Ser Gln Ala Gln Ala Ser Ser Val Glu 
            100                 105                 110         


Pro Gly Ser Arg Thr Gly Pro Asp Gln Pro Leu Arg Gln Glu Ser Ser 
        115                 120                 125             


Ser Thr Leu Pro Leu Gly Gly Phe Gln Thr His Pro Thr Leu Leu Trp 
    130                 135                 140                 


Glu Leu Thr Leu Asn Gly Gly Pro Leu Val Arg Ser Lys Pro Ser Glu 
145                 150                 155                 160 


Pro Pro Pro Gly Asp Arg Thr Ser Gln Leu Gln Ser 
                165                 170         


<210>  6563
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  6563

Met Arg Ser Gly Glu Glu Leu Asp Gly Phe Glu Gly Glu Ala Ser Ser 
1               5                   10                  15      


Thr Ser Met Ile Ser Gly Ala Ser Ser Pro Tyr Gln Pro Thr Thr Glu 
            20                  25                  30          


Pro Val Ser Gln Arg Arg Gly Leu Ala Gly Leu Arg Cys Asp Pro Asp 
        35                  40                  45              


Tyr Leu Arg Gly Ala Leu Gly Arg Leu Lys Val Ala Gln Val Ile Leu 
    50                  55                  60                  


Ala Leu Ile Ala Phe Ile Cys Ile Glu Thr Ile Met Ala Cys Ser Pro 
65                  70                  75                  80  


Cys Glu Gly Leu Tyr Phe Phe Glu Phe Val Ser Cys Ser Ala Phe Val 
                85                  90                  95      


Val Thr Gly Val Leu Leu Ile Met Phe Ser Leu Asn Leu His Met Arg 
            100                 105                 110         


Ile Pro Gln Ile Asn Trp Asn Leu Thr Asp Leu Val Asn Thr Gly Leu 
        115                 120                 125             


Ser Ala Phe Leu Phe Phe Ile Ala Ser Ile Val Leu Ala Ala Leu Asn 
    130                 135                 140                 


His Arg Ala Gly Ala Glu Ile Ala Ala Val Ile Phe Gly Phe Leu Ala 
145                 150                 155                 160 


Thr Ala Ala Tyr Ala Val Asn Thr Phe Leu Ala Val Gln Lys Trp Arg 
                165                 170                 175     


Val Ser Val Arg Gln Gln Ser Thr Asn Asp Tyr Ile Arg Ala Arg Thr 
            180                 185                 190         


Glu Ser Arg Asp Val Asp Ser Arg Pro Glu Ile Gln Arg Leu Asp Thr 
        195                 200                 205             


Phe Ser Tyr Ser Thr Asn Val Thr Val Arg Lys Lys Ser Pro Thr Asn 
    210                 215                 220                 


Leu Leu Ser Leu Asn His Trp Gln Leu Ala 
225                 230                 


<210>  6564
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  6564

Met Phe Leu Leu Leu Pro Phe Asp Ser Leu Ile Val Asn Leu Leu Gly 
1               5                   10                  15      


Ile Ser Leu Thr Val Leu Phe Thr Leu Leu Leu Val Phe Ile Ile Val 
            20                  25                  30          


Pro Ala Ile Phe Gly Val Ser Phe Gly Ile Arg Lys Leu Tyr Met Lys 
        35                  40                  45              


Ser Leu Leu Lys Ile Phe Ala Trp Ala Thr Leu Arg Met Glu Arg Gly 
    50                  55                  60                  


Ala Lys Glu Lys Asn His Gln Leu Tyr Lys Pro Tyr Thr Asn Gly Ile 
65                  70                  75                  80  


Ile Ala Lys Asp Pro Thr Ser Leu Glu Glu Glu Ile Lys Glu Ile Arg 
                85                  90                  95      


Arg Ser Gly Ser Ser Lys Ala Leu Asp Asn Thr Pro Glu Phe Glu Leu 
            100                 105                 110         


Ser Asp Ile Phe Tyr Phe Cys Arg Lys Gly Met Glu Thr Ile Met Asp 
        115                 120                 125             


Asp Glu Val Thr Lys Arg Phe Ser Ala Glu Glu Leu Glu Ser Trp Asn 
    130                 135                 140                 


Leu Leu Ser Arg Thr Asn Tyr Asn Phe Gln Tyr Ile Ser Leu Arg Leu 
145                 150                 155                 160 


Thr Val Leu Trp Gly Leu Gly Val Leu Ile Arg Tyr Cys Phe Leu Leu 
                165                 170                 175     


Pro Leu Arg Ile Ala Leu Ala Phe Thr Gly Ile Ser Leu Leu Val Val 
            180                 185                 190         


Gly Thr Thr Val Val Gly Tyr Leu Pro Asn Gly Arg Phe Lys Glu Phe 
        195                 200                 205             


Met Ser Lys His Val His Leu Met Cys Tyr Arg Ile Cys Val Arg Ala 
    210                 215                 220                 


Leu Thr Ala Ile Ile Thr Tyr His Asp Arg Glu Asn Arg Pro Arg Asn 
225                 230                 235                 240 


Gly Gly Ile Cys Val Ala Asn His Thr Ser Pro Ile Asp Val Ile Ile 
                245                 250                 255     


Leu Ala Ser Asp Gly Tyr Tyr Ala Met Val Gly Gln Val His Gly Gly 
            260                 265                 270         


Leu Met Gly Val Ile Gln Arg Ala Met Val Lys Ala Cys Pro His Val 
        275                 280                 285             


Trp Phe Glu Arg Ser Glu Val Lys Asp Arg His Leu Val Ala Lys Arg 
    290                 295                 300                 


Leu Thr Glu His Val Gln Asp Lys Ser Lys Leu Pro Ile Leu Ile Phe 
305                 310                 315                 320 


Pro Glu Gly Thr Cys Ile Asn Asn Thr Ser Val Met Met Phe Lys Lys 
                325                 330                 335     


Gly Ser Phe Glu Ile Gly Ala Thr Val Tyr Pro Val Ala Ile Lys Tyr 
            340                 345                 350         


Asp Pro Gln Phe Gly Asp Ala Phe Trp Asn Ser Ser Lys Tyr Gly Met 
        355                 360                 365             


Val Thr Tyr Leu Leu Arg Met Met Thr Ser Trp Ala Ile Val Cys Ser 
    370                 375                 380                 


Val Trp Tyr Leu Pro Pro Met Thr Arg Glu Ala Asp Glu Asp Ala Val 
385                 390                 395                 400 


Gln Phe Ala Asn Arg Val Lys Ser Ala Ile Ala Arg Gln Gly Gly Leu 
                405                 410                 415     


Val Asp Leu Leu Trp Asp Gly Gly Leu Lys Arg Glu Lys Val Lys Asp 
            420                 425                 430         


Thr Phe Lys Glu Glu Gln Gln Lys Leu Tyr Ser Lys Met Ile Val Gly 
        435                 440                 445             


Asn His Lys Asp Arg Ser Arg Ser 
    450                 455     


<210>  6565
<211>  2623
<212>  PRT
<213>  Homo sapiens

<400>  6565

Met Lys Val Lys Gly Arg Gly Ile Thr Cys Leu Leu Val Ser Phe Ala 
1               5                   10                  15      


Val Ile Cys Leu Val Ala Thr Pro Gly Gly Lys Ala Cys Pro Arg Arg 
            20                  25                  30          


Cys Ala Cys Tyr Met Pro Thr Glu Val His Cys Thr Phe Arg Tyr Leu 
        35                  40                  45              


Thr Ser Ile Pro Asp Ser Ile Pro Pro Asn Val Glu Arg Ile Asn Leu 
    50                  55                  60                  


Gly Tyr Asn Ser Leu Val Arg Leu Met Glu Thr Asp Phe Ser Gly Leu 
65                  70                  75                  80  


Thr Lys Leu Glu Leu Leu Met Leu His Ser Asn Gly Ile His Thr Ile 
                85                  90                  95      


Pro Asp Lys Thr Phe Ser Asp Leu Gln Ala Leu Gln Val Leu Lys Met 
            100                 105                 110         


Ser Tyr Asn Lys Val Arg Lys Leu Gln Lys Asp Thr Phe Tyr Gly Leu 
        115                 120                 125             


Arg Ser Leu Thr Arg Leu His Met Asp His Asn Asn Ile Glu Phe Ile 
    130                 135                 140                 


Asn Pro Glu Val Phe Tyr Gly Leu Asn Phe Leu Arg Leu Val His Leu 
145                 150                 155                 160 


Glu Gly Asn Gln Leu Thr Lys Leu His Pro Asp Thr Phe Val Ser Leu 
                165                 170                 175     


Ser Tyr Leu Gln Ile Phe Lys Ile Ser Phe Ile Lys Phe Leu Tyr Leu 
            180                 185                 190         


Ser Asp Asn Phe Leu Thr Ser Leu Pro Gln Glu Met Val Ser Tyr Met 
        195                 200                 205             


Pro Asp Leu Asp Ser Leu Tyr Leu His Gly Asn Pro Trp Thr Cys Asp 
    210                 215                 220                 


Cys His Leu Lys Trp Leu Ser Asp Trp Ile Gln Glu Lys Pro Asp Val 
225                 230                 235                 240 


Ile Lys Cys Lys Lys Asp Arg Ser Pro Ser Ser Ala Gln Gln Cys Pro 
                245                 250                 255     


Leu Cys Met Asn Pro Arg Thr Ser Lys Gly Lys Pro Leu Ala Met Val 
            260                 265                 270         


Ser Ala Ala Ala Phe Gln Cys Ala Lys Pro Thr Ile Asp Ser Ser Leu 
        275                 280                 285             


Lys Ser Lys Ser Leu Thr Ile Leu Glu Asp Ser Ser Ser Ala Phe Ile 
    290                 295                 300                 


Ser Pro Gln Gly Phe Met Ala Pro Phe Gly Ser Leu Thr Leu Asn Met 
305                 310                 315                 320 


Thr Asp Gln Ser Gly Asn Glu Ala Asn Met Val Cys Ser Ile Gln Lys 
                325                 330                 335     


Pro Ser Arg Thr Ser Pro Ile Ala Phe Thr Glu Glu Asn Asp Tyr Ile 
            340                 345                 350         


Val Leu Asn Thr Ser Phe Ser Thr Phe Leu Val Cys Asn Ile Asp Tyr 
        355                 360                 365             


Gly His Ile Gln Pro Val Trp Gln Ile Leu Ala Leu Tyr Ser Asp Ser 
    370                 375                 380                 


Pro Leu Ile Leu Glu Arg Ser His Leu Leu Ser Glu Thr Pro Gln Leu 
385                 390                 395                 400 


Tyr Tyr Lys Tyr Lys Gln Val Ala Pro Lys Pro Glu Asp Ile Phe Thr 
                405                 410                 415     


Asn Ile Glu Ala Asp Leu Arg Ala Asp Pro Ser Trp Leu Met Gln Asp 
            420                 425                 430         


Gln Ile Ser Leu Gln Leu Asn Arg Thr Ala Thr Thr Phe Ser Thr Leu 
        435                 440                 445             


Gln Ile Gln Tyr Ser Ser Asp Ala Gln Ile Thr Leu Pro Arg Ala Glu 
    450                 455                 460                 


Met Arg Pro Val Lys His Lys Trp Thr Met Ile Ser Arg Asp Asn Asn 
465                 470                 475                 480 


Thr Lys Leu Glu His Thr Val Leu Val Gly Gly Thr Val Gly Leu Asn 
                485                 490                 495     


Cys Pro Gly Gln Gly Asp Pro Thr Pro His Val Asp Trp Leu Leu Ala 
            500                 505                 510         


Asp Gly Ser Lys Val Arg Ala Pro Tyr Val Ser Glu Asp Gly Arg Ile 
        515                 520                 525             


Leu Ile Asp Lys Ser Gly Lys Leu Glu Leu Gln Met Ala Asp Ser Phe 
    530                 535                 540                 


Asp Thr Gly Val Tyr His Cys Ile Ser Ser Asn Tyr Asp Asp Ala Asp 
545                 550                 555                 560 


Ile Leu Thr Tyr Arg Ile Thr Val Val Glu Pro Leu Val Glu Ala Tyr 
                565                 570                 575     


Gln Glu Asn Gly Ile His His Thr Val Phe Ile Gly Glu Thr Leu Asp 
            580                 585                 590         


Leu Pro Cys His Ser Thr Gly Ile Pro Asp Ala Ser Ile Ser Trp Val 
        595                 600                 605             


Ile Pro Gly Asn Asn Val Leu Tyr Gln Ser Ser Arg Asp Lys Lys Val 
    610                 615                 620                 


Leu Asn Asn Gly Thr Leu Arg Ile Leu Gln Val Thr Pro Lys Asp Gln 
625                 630                 635                 640 


Gly Tyr Tyr Arg Cys Val Ala Ala Asn Pro Ser Gly Val Asp Phe Leu 
                645                 650                 655     


Ile Phe Gln Val Ser Val Lys Met Lys Gly Gln Arg Pro Leu Glu His 
            660                 665                 670         


Asp Gly Glu Thr Glu Gly Ser Gly Leu Asp Glu Ser Asn Pro Ile Ala 
        675                 680                 685             


His Leu Lys Glu Pro Pro Gly Ala Gln Leu Arg Thr Ser Ala Leu Met 
    690                 695                 700                 


Glu Ala Glu Val Gly Lys His Thr Ser Ser Thr Ser Lys Arg His Asn 
705                 710                 715                 720 


Tyr Arg Glu Leu Thr Leu Gln Arg Arg Gly Asp Ser Thr His Arg Arg 
                725                 730                 735     


Phe Arg Glu Asn Arg Arg His Phe Pro Pro Ser Ala Arg Arg Ile Asp 
            740                 745                 750         


Pro Gln His Trp Ala Ala Leu Leu Glu Lys Ala Lys Lys Asn Ala Met 
        755                 760                 765             


Pro Asp Lys Arg Glu Asn Thr Thr Val Ser Pro Pro Pro Val Val Thr 
    770                 775                 780                 


Gln Leu Pro Asn Ile Pro Gly Glu Glu Asp Asp Ser Ser Gly Met Leu 
785                 790                 795                 800 


Ala Leu His Glu Glu Phe Met Val Pro Ala Thr Lys Ala Leu Asn Leu 
                805                 810                 815     


Pro Ala Arg Thr Val Thr Ala Asp Ser Arg Thr Ile Ser Asp Ser Pro 
            820                 825                 830         


Met Thr Asn Ile Asn Tyr Gly Thr Glu Phe Ser Pro Val Val Asn Ser 
        835                 840                 845             


Gln Ile Leu Pro Pro Glu Glu Pro Thr Asp Phe Lys Leu Ser Thr Ala 
    850                 855                 860                 


Ile Lys Thr Thr Ala Met Ser Lys Asn Ile Asn Pro Thr Met Ser Ser 
865                 870                 875                 880 


Gln Ile Gln Gly Thr Thr Asn Gln His Ser Ser Thr Val Phe Pro Leu 
                885                 890                 895     


Leu Leu Gly Ala Thr Glu Phe Gln Asp Ser Asp Gln Met Gly Arg Gly 
            900                 905                 910         


Arg Glu His Phe Gln Ser Arg Pro Pro Ile Thr Val Arg Thr Met Ile 
        915                 920                 925             


Lys Asp Val Asn Val Lys Met Leu Ser Ser Thr Thr Asn Lys Leu Leu 
    930                 935                 940                 


Leu Glu Ser Val Asn Thr Thr Asn Ser His Gln Thr Ser Val Arg Glu 
945                 950                 955                 960 


Val Ser Glu Pro Arg His Asn His Phe Tyr Ser His Thr Thr Gln Ile 
                965                 970                 975     


Leu Ser Thr Ser Thr Phe Pro Ser Asp Pro His Thr Ala Ala His Ser 
            980                 985                 990         


Gln Phe Pro Ile Pro Arg Asn Ser  Thr Val Asn Ile Pro  Leu Phe Arg 
        995                 1000                 1005             


Arg Phe  Gly Arg Gln Arg Lys  Ile Gly Gly Arg Gly  Arg Ile Ile 
    1010                 1015                 1020             


Ser Pro  Tyr Arg Thr Pro Val  Leu Arg Arg His Arg  Tyr Ser Ile 
    1025                 1030                 1035             


Phe Arg  Ser Thr Thr Arg Gly  Ser Ser Glu Lys Ser  Thr Thr Ala 
    1040                 1045                 1050             


Phe Ser  Ala Thr Val Leu Asn  Val Thr Cys Leu Ser  Cys Leu Pro 
    1055                 1060                 1065             


Arg Glu  Arg Leu Thr Thr Ala  Thr Ala Ala Leu Ser  Phe Pro Ser 
    1070                 1075                 1080             


Ala Ala  Pro Ile Thr Phe Pro  Lys Ala Asp Ile Ala  Arg Val Pro 
    1085                 1090                 1095             


Ser Glu  Glu Ser Thr Thr Leu  Val Gln Asn Pro Leu  Leu Leu Leu 
    1100                 1105                 1110             


Glu Asn  Lys Pro Ser Val Glu  Lys Thr Thr Pro Thr  Ile Lys Tyr 
    1115                 1120                 1125             


Phe Arg  Thr Glu Ile Ser Gln  Val Thr Pro Thr Gly  Ala Val Met 
    1130                 1135                 1140             


Thr Tyr  Ala Pro Thr Ser Ile  Pro Met Glu Lys Thr  His Lys Val 
    1145                 1150                 1155             


Asn Ala  Ser Tyr Pro Arg Val  Ser Ser Thr Asn Glu  Ala Lys Arg 
    1160                 1165                 1170             


Asp Ser  Val Ile Thr Ser Ser  Leu Ser Gly Ala Ile  Thr Lys Pro 
    1175                 1180                 1185             


Pro Met  Thr Ile Ile Ala Ile  Thr Arg Phe Ser Arg  Arg Lys Ile 
    1190                 1195                 1200             


Pro Trp  Gln Gln Asn Phe Val  Asn Asn His Asn Pro  Lys Gly Arg 
    1205                 1210                 1215             


Leu Arg  Asn Gln His Lys Val  Ser Leu Gln Lys Ser  Thr Ala Val 
    1220                 1225                 1230             


Met Leu  Pro Lys Thr Ser Pro  Ala Leu Pro Arg Asp  Lys Val Ser 
    1235                 1240                 1245             


Pro Phe  His Phe Thr Thr Leu  Ser Thr Ser Val Met  Gln Ile Pro 
    1250                 1255                 1260             


Ser Asn  Thr Leu Thr Thr Ala  His His Thr Thr Thr  Lys Thr His 
    1265                 1270                 1275             


Asn Pro  Gly Ser Leu Pro Thr  Lys Lys Glu Leu Pro  Phe Pro Pro 
    1280                 1285                 1290             


Leu Asn  Pro Met Leu Pro Ser  Ile Ile Ser Lys Asp  Ser Ser Thr 
    1295                 1300                 1305             


Lys Ser  Ile Ile Ser Thr Gln  Thr Ala Ile Pro Ala  Thr Thr Pro 
    1310                 1315                 1320             


Thr Phe  Pro Ala Ser Val Ile  Thr Tyr Glu Thr Gln  Thr Glu Arg 
    1325                 1330                 1335             


Ser Arg  Ala Gln Thr Ile Gln  Arg Glu Gln Glu Pro  Gln Lys Lys 
    1340                 1345                 1350             


Asn Arg  Thr Asp Pro Asn Ile  Ser Pro Asp Gln Ser  Ser Gly Phe 
    1355                 1360                 1365             


Thr Thr  Pro Thr Ala Met Thr  Pro Pro Val Leu Thr  Thr Ala Glu 
    1370                 1375                 1380             


Thr Ser  Val Lys Pro Ser Val  Ser Ala Phe Thr His  Ser Pro Pro 
    1385                 1390                 1395             


Glu Asn  Thr Thr Gly Ile Ser  Ser Thr Ile Ser Phe  His Ser Arg 
    1400                 1405                 1410             


Thr Leu  Asn Leu Thr Asp Val  Ile Glu Glu Leu Ala  Gln Ala Ser 
    1415                 1420                 1425             


Thr Gln  Thr Leu Lys Ser Thr  Ile Ala Ser Glu Thr  Thr Leu Ser 
    1430                 1435                 1440             


Ser Lys  Ser His Gln Ser Thr  Thr Thr Arg Lys Ala  Ile Ile Arg 
    1445                 1450                 1455             


His Ser  Thr Ile Pro Pro Phe  Leu Ser Ser Ser Ala  Thr Leu Met 
    1460                 1465                 1470             


Pro Val  Pro Ile Ser Pro Pro  Phe Thr Gln Arg Ala  Val Thr Asp 
    1475                 1480                 1485             


Asn Val  Ala Thr Pro Ile Ser  Gly Leu Met Thr Asn  Thr Val Val 
    1490                 1495                 1500             


Lys Leu  His Glu Ser Ser Arg  His Asn Ala Lys Pro  Gln Gln Leu 
    1505                 1510                 1515             


Val Ala  Glu Val Ala Thr Ser  Pro Lys Val His Pro  Asn Ala Lys 
    1520                 1525                 1530             


Phe Thr  Ile Gly Thr Thr His  Phe Ile Tyr Ser Asn  Leu Leu His 
    1535                 1540                 1545             


Ser Thr  Pro Met Pro Ala Leu  Thr Thr Val Lys Ser  Gln Asn Ser 
    1550                 1555                 1560             


Lys Leu  Thr Pro Ser Pro Trp  Ala Glu Asn Gln Phe  Trp His Lys 
    1565                 1570                 1575             


Pro Tyr  Ser Glu Ile Ala Glu  Lys Gly Lys Lys Pro  Glu Val Ser 
    1580                 1585                 1590             


Met Leu  Ala Thr Thr Gly Leu  Ser Glu Ala Thr Thr  Leu Val Ser 
    1595                 1600                 1605             


Asp Trp  Asp Gly Gln Lys Asn  Thr Lys Lys Ser Asp  Phe Asp Lys 
    1610                 1615                 1620             


Lys Pro  Val Gln Glu Ala Thr  Thr Ser Lys Leu Leu  Pro Phe Asp 
    1625                 1630                 1635             


Ser Leu  Ser Arg Tyr Ile Phe  Glu Lys Pro Arg Ile  Val Gly Gly 
    1640                 1645                 1650             


Lys Ala  Ala Ser Phe Thr Ile  Pro Ala Asn Ser Asp  Ala Phe Leu 
    1655                 1660                 1665             


Pro Cys  Glu Ala Val Gly Asn  Pro Leu Pro Thr Ile  His Trp Thr 
    1670                 1675                 1680             


Arg Val  Pro Ser Gly Leu Asp  Leu Ser Lys Arg Lys  Gln Asn Ser 
    1685                 1690                 1695             


Arg Val  Gln Val Leu Pro Asn  Gly Thr Leu Ser Ile  Gln Arg Val 
    1700                 1705                 1710             


Glu Ile  Gln Asp Arg Gly Gln  Tyr Leu Cys Ser Ala  Ser Asn Leu 
    1715                 1720                 1725             


Phe Gly  Thr Asp His Leu His  Val Thr Leu Ser Val  Val Ser Tyr 
    1730                 1735                 1740             


Pro Pro  Arg Ile Leu Glu Arg  Arg Thr Lys Glu Ile  Thr Val His 
    1745                 1750                 1755             


Ser Gly  Ser Thr Val Glu Leu  Lys Cys Arg Ala Glu  Gly Arg Pro 
    1760                 1765                 1770             


Ser Pro  Thr Val Thr Trp Ile  Leu Ala Asn Gln Thr  Val Val Ser 
    1775                 1780                 1785             


Glu Ser  Ser Gln Gly Ser Arg  Gln Ala Val Val Thr  Val Asp Gly 
    1790                 1795                 1800             


Thr Leu  Val Leu His Asn Leu  Ser Ile Tyr Asp Arg  Gly Phe Tyr 
    1805                 1810                 1815             


Lys Cys  Val Ala Ser Asn Pro  Gly Gly Gln Asp Ser  Leu Leu Val 
    1820                 1825                 1830             


Lys Ile  Gln Val Ile Ala Ala  Pro Pro Val Ile Leu  Glu Gln Arg 
    1835                 1840                 1845             


Arg Gln  Val Ile Val Gly Thr  Trp Gly Glu Ser Leu  Lys Leu Pro 
    1850                 1855                 1860             


Cys Thr  Ala Lys Gly Thr Pro  Gln Pro Ser Val Tyr  Trp Val Leu 
    1865                 1870                 1875             


Ser Asp  Gly Thr Glu Val Lys  Pro Leu Gln Phe Thr  Asn Ser Lys 
    1880                 1885                 1890             


Leu Phe  Leu Phe Ser Asn Gly  Thr Leu Tyr Ile Arg  Asn Leu Ala 
    1895                 1900                 1905             


Ser Ser  Asp Arg Gly Thr Tyr  Glu Cys Ile Ala Thr  Ser Ser Thr 
    1910                 1915                 1920             


Gly Ser  Glu Arg Arg Val Val  Met Leu Thr Met Glu  Glu Arg Val 
    1925                 1930                 1935             


Thr Ser  Pro Arg Ile Glu Ala  Ala Ser Gln Lys Arg  Thr Glu Val 
    1940                 1945                 1950             


Asn Phe  Gly Asp Lys Leu Leu  Leu Asn Cys Ser Ala  Thr Gly Glu 
    1955                 1960                 1965             


Pro Lys  Pro Gln Ile Met Trp  Arg Leu Pro Ser Lys  Ala Val Val 
    1970                 1975                 1980             


Asp Gln  Gln His Arg Val Gly  Ser Trp Ile His Val  Tyr Pro Asn 
    1985                 1990                 1995             


Gly Ser  Leu Phe Ile Gly Ser  Val Thr Glu Lys Asp  Ser Gly Val 
    2000                 2005                 2010             


Tyr Leu  Cys Val Ala Arg Asn  Lys Met Gly Asp Asp  Leu Ile Leu 
    2015                 2020                 2025             


Met His  Val Ser Leu Arg Leu  Lys Pro Ala Lys Ile  Asp His Lys 
    2030                 2035                 2040             


Gln Tyr  Phe Arg Lys Gln Val  Leu His Gly Lys Asp  Phe Gln Val 
    2045                 2050                 2055             


Asp Cys  Lys Ala Ser Gly Ser  Pro Val Pro Glu Ile  Ser Trp Ser 
    2060                 2065                 2070             


Leu Pro  Asp Gly Thr Met Ile  Asn Asn Ala Met Gln  Ala Asp Asp 
    2075                 2080                 2085             


Ser Gly  His Arg Thr Arg Arg  Tyr Thr Leu Phe Asn  Asn Gly Thr 
    2090                 2095                 2100             


Leu Tyr  Phe Asn Lys Val Gly  Val Ala Glu Glu Gly  Asp Tyr Thr 
    2105                 2110                 2115             


Cys Tyr  Ala Gln Asn Thr Leu  Gly Lys Asp Glu Met  Lys Val His 
    2120                 2125                 2130             


Leu Thr  Val Ile Thr Ala Ala  Pro Arg Ile Arg Gln  Ser Asn Lys 
    2135                 2140                 2145             


Thr Asn  Lys Arg Ile Lys Ala  Gly Asp Thr Ala Val  Leu Asp Cys 
    2150                 2155                 2160             


Glu Val  Thr Gly Asp Pro Lys  Pro Lys Ile Phe Trp  Leu Leu Pro 
    2165                 2170                 2175             


Ser Asn  Asp Met Ile Ser Phe  Ser Ile Asp Arg Tyr  Thr Phe His 
    2180                 2185                 2190             


Ala Asn  Gly Ser Leu Thr Ile  Asn Lys Val Lys Leu  Leu Asp Ser 
    2195                 2200                 2205             


Gly Glu  Tyr Val Cys Val Ala  Arg Asn Pro Ser Gly  Asp Asp Thr 
    2210                 2215                 2220             


Lys Met  Tyr Lys Leu Asp Val  Val Ser Lys Pro Pro  Leu Ile Asn 
    2225                 2230                 2235             


Gly Leu  Tyr Thr Asn Arg Thr  Val Ile Lys Ala Thr  Ala Val Arg 
    2240                 2245                 2250             


His Ser  Lys Lys His Phe Asp  Cys Arg Ala Glu Gly  Thr Pro Ser 
    2255                 2260                 2265             


Pro Glu  Val Met Trp Ile Met  Pro Asp Asn Ile Phe  Leu Thr Ala 
    2270                 2275                 2280             


Pro Tyr  Tyr Gly Ser Arg Ile  Thr Val His Lys Asn  Gly Thr Leu 
    2285                 2290                 2295             


Glu Ile  Arg Asn Val Arg Leu  Ser Asp Ser Ala Asp  Phe Ile Cys 
    2300                 2305                 2310             


Val Ala  Arg Asn Glu Gly Gly  Glu Ser Val Leu Val  Val Gln Leu 
    2315                 2320                 2325             


Glu Val  Leu Glu Met Leu Arg  Arg Pro Thr Phe Arg  Asn Pro Phe 
    2330                 2335                 2340             


Asn Glu  Lys Ile Val Ala Gln  Leu Gly Lys Ser Thr  Ala Leu Asn 
    2345                 2350                 2355             


Cys Ser  Val Asp Gly Asn Pro  Pro Pro Glu Ile Ile  Trp Ile Leu 
    2360                 2365                 2370             


Pro Asn  Gly Thr Arg Phe Ser  Asn Gly Pro Gln Ser  Tyr Gln Tyr 
    2375                 2380                 2385             


Leu Ile  Ala Ser Asn Gly Ser  Phe Ile Ile Ser Lys  Thr Thr Arg 
    2390                 2395                 2400             


Glu Asp  Ala Gly Lys Tyr Arg  Cys Ala Ala Arg Asn  Lys Val Gly 
    2405                 2410                 2415             


Tyr Ile  Glu Lys Leu Val Ile  Leu Glu Ile Gly Gln  Lys Pro Val 
    2420                 2425                 2430             


Ile Leu  Thr Tyr Ala Pro Gly  Thr Val Lys Gly Ile  Ser Gly Glu 
    2435                 2440                 2445             


Ser Leu  Ser Leu His Cys Val  Ser Asp Gly Ile Pro  Lys Pro Asn 
    2450                 2455                 2460             


Ile Lys  Trp Thr Met Pro Ser  Gly Tyr Val Val Asp  Arg Pro Gln 
    2465                 2470                 2475             


Ile Asn  Gly Lys Tyr Ile Leu  His Asp Asn Gly Thr  Leu Val Ile 
    2480                 2485                 2490             


Lys Glu  Ala Thr Ala Tyr Asp  Arg Gly Asn Tyr Ile  Cys Lys Ala 
    2495                 2500                 2505             


Gln Asn  Ser Val Gly His Thr  Leu Ile Thr Val Pro  Val Met Ile 
    2510                 2515                 2520             


Val Ala  Tyr Pro Pro Arg Ile  Thr Asn Arg Pro Pro  Arg Ser Ile 
    2525                 2530                 2535             


Val Thr  Arg Thr Gly Ala Ala  Phe Gln Leu His Cys  Val Ala Leu 
    2540                 2545                 2550             


Gly Val  Pro Lys Pro Glu Ile  Thr Trp Glu Met Pro  Asp His Ser 
    2555                 2560                 2565             


Leu Leu  Ser Thr Ala Ser Lys  Glu Arg Thr His Gly  Ser Glu Gln 
    2570                 2575                 2580             


Leu His  Leu Gln Gly Thr Leu  Val Ile Gln Asn Pro  Gln Thr Ser 
    2585                 2590                 2595             


Asp Ser  Gly Ile Tyr Lys Cys  Thr Ala Lys Asn Pro  Leu Gly Ser 
    2600                 2605                 2610             


Asp Tyr  Ala Ala Thr Tyr Ile  Gln Val Ile 
    2615                 2620             


<210>  6566
<211>  920
<212>  PRT
<213>  Homo sapiens

<400>  6566

Met Glu Ala Ser Ser Ser Gly Ile Thr Asn Gly Lys Thr Lys Val Phe 
1               5                   10                  15      


His Pro Val Ala Lys Asp Val Asn Ile Leu Phe Asp Glu Leu Glu Ala 
            20                  25                  30          


Val Ser Ser Pro Cys Lys Asp Asp Asp Ser Leu Leu His Pro Gly Asn 
        35                  40                  45              


Leu Thr Ser Thr Ser Asp Asp Ala Ser Arg Leu Glu Ala Gly Gly Glu 
    50                  55                  60                  


Thr Val Pro Glu Arg Asn Lys Ser Asn Gly Leu Tyr Phe Arg Asp Gly 
65                  70                  75                  80  


Lys Cys Arg Ile Asp Tyr Ile Leu Val Tyr Arg Lys Ser Asn Pro Gln 
                85                  90                  95      


Thr Glu Lys Arg Glu Val Phe Glu Arg Asn Ile Arg Ala Glu Gly Leu 
            100                 105                 110         


Gln Met Glu Lys Glu Ser Ser Leu Ile Asn Ser Asp Ile Ile Phe Val 
        115                 120                 125             


Lys Leu His Ala Pro Trp Glu Val Leu Gly Arg Tyr Ala Glu Gln Met 
    130                 135                 140                 


Asn Val Arg Met Pro Phe Arg Arg Lys Ile Tyr Tyr Leu Pro Arg Arg 
145                 150                 155                 160 


Tyr Lys Phe Met Ser Arg Ile Asp Lys Gln Ile Ser Arg Phe Arg Arg 
                165                 170                 175     


Trp Leu Pro Lys Lys Pro Met Arg Leu Asp Lys Glu Thr Leu Pro Asp 
            180                 185                 190         


Leu Glu Glu Asn Asp Cys Tyr Thr Ala Pro Phe Ser Gln Gln Arg Ile 
        195                 200                 205             


His His Phe Ile Ile His Asn Lys Glu Thr Phe Phe Asn Asn Ala Thr 
    210                 215                 220                 


Arg Ser Arg Ile Val His His Ile Leu Gln Arg Ile Lys Tyr Glu Glu 
225                 230                 235                 240 


Gly Lys Asn Lys Ile Gly Leu Asn Arg Leu Leu Thr Asn Gly Ser Tyr 
                245                 250                 255     


Glu Ala Ala Phe Pro Leu His Glu Gly Ser Tyr Arg Ser Lys Asn Ser 
            260                 265                 270         


Ile Arg Thr His Gly Ala Glu Asn His Arg His Leu Leu Tyr Glu Cys 
        275                 280                 285             


Trp Ala Ser Trp Gly Val Trp Tyr Lys Tyr Gln Pro Leu Asp Leu Val 
    290                 295                 300                 


Arg Arg Tyr Phe Gly Glu Lys Ile Gly Leu Tyr Phe Ala Trp Leu Gly 
305                 310                 315                 320 


Trp Tyr Thr Gly Met Leu Phe Pro Ala Ala Phe Ile Gly Leu Phe Val 
                325                 330                 335     


Phe Leu Tyr Gly Val Thr Thr Leu Asp His Ser Gln Val Ser Lys Glu 
            340                 345                 350         


Val Cys Gln Ala Thr Asp Ile Ile Met Cys Pro Val Cys Asp Lys Tyr 
        355                 360                 365             


Cys Pro Phe Met Arg Leu Ser Asp Ser Cys Val Tyr Ala Lys Val Thr 
    370                 375                 380                 


His Leu Phe Asp Asn Gly Ala Thr Val Phe Phe Ala Val Phe Met Ala 
385                 390                 395                 400 


Val Trp Ala Thr Val Phe Leu Glu Phe Trp Lys Arg Arg Arg Ala Val 
                405                 410                 415     


Ile Ala Tyr Asp Trp Asp Leu Ile Asp Trp Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Ile Arg Pro Gln Phe Glu Ala Lys Tyr Ser Lys Lys Glu Arg Met Asn 
        435                 440                 445             


Pro Ile Ser Gly Lys Pro Glu Pro Tyr Gln Ala Phe Thr Asp Lys Cys 
    450                 455                 460                 


Ser Arg Leu Ile Val Ser Ala Ser Gly Ile Phe Phe Met Ile Cys Val 
465                 470                 475                 480 


Val Ile Ala Ala Val Phe Gly Ile Val Ile Tyr Arg Val Val Thr Val 
                485                 490                 495     


Ser Thr Phe Ala Ala Phe Lys Trp Ala Leu Ile Arg Asn Asn Ser Gln 
            500                 505                 510         


Val Ala Thr Thr Gly Thr Ala Val Cys Ile Asn Phe Cys Ile Ile Met 
        515                 520                 525             


Leu Leu Asn Val Leu Tyr Glu Lys Val Ala Leu Leu Leu Thr Asn Leu 
    530                 535                 540                 


Glu Gln Pro Arg Thr Glu Ser Glu Trp Glu Asn Ser Phe Thr Leu Lys 
545                 550                 555                 560 


Met Phe Leu Phe Gln Phe Val Asn Leu Asn Ser Ser Thr Phe Tyr Ile 
                565                 570                 575     


Ala Phe Phe Leu Gly Arg Phe Thr Gly His Pro Gly Ala Tyr Leu Arg 
            580                 585                 590         


Leu Ile Asn Arg Trp Arg Leu Glu Glu Cys His Pro Ser Gly Cys Leu 
        595                 600                 605             


Ile Asp Leu Cys Met Gln Met Gly Ile Ile Met Val Leu Lys Gln Thr 
    610                 615                 620                 


Trp Asn Asn Phe Met Glu Leu Gly Tyr Pro Leu Ile Gln Asn Trp Trp 
625                 630                 635                 640 


Thr Arg Arg Lys Val Arg Gln Glu His Gly Pro Glu Arg Lys Ile Ser 
                645                 650                 655     


Phe Pro Gln Trp Glu Lys Asp Tyr Asn Leu Gln Pro Met Asn Ala Tyr 
            660                 665                 670         


Gly Leu Phe Asp Glu Tyr Leu Glu Met Ile Leu Gln Phe Gly Phe Thr 
        675                 680                 685             


Thr Ile Phe Val Ala Ala Phe Pro Leu Ala Pro Leu Leu Ala Leu Leu 
    690                 695                 700                 


Asn Asn Ile Ile Glu Ile Arg Leu Asp Ala Tyr Lys Phe Val Thr Gln 
705                 710                 715                 720 


Trp Arg Arg Pro Leu Ala Ser Arg Ala Lys Asp Ile Gly Ile Trp Tyr 
                725                 730                 735     


Gly Ile Leu Glu Gly Ile Gly Ile Leu Ser Val Ile Thr Asn Ala Phe 
            740                 745                 750         


Val Ile Ala Ile Thr Ser Asp Phe Ile Pro Arg Leu Val Tyr Ala Tyr 
        755                 760                 765             


Lys Tyr Gly Pro Cys Ala Gly Gln Gly Glu Ala Gly Gln Lys Cys Met 
    770                 775                 780                 


Val Gly Tyr Val Asn Ala Ser Leu Ser Val Phe Arg Ile Ser Asp Phe 
785                 790                 795                 800 


Glu Asn Arg Ser Glu Pro Glu Ser Asp Gly Ser Glu Phe Ser Gly Thr 
                805                 810                 815     


Pro Leu Lys Tyr Cys Arg Tyr Arg Asp Tyr Arg Asp Pro Pro His Ser 
            820                 825                 830         


Leu Val Pro Tyr Gly Tyr Thr Leu Gln Phe Trp His Val Leu Ala Ala 
        835                 840                 845             


Arg Leu Ala Phe Ile Ile Val Phe Glu His Leu Val Phe Cys Ile Lys 
    850                 855                 860                 


His Leu Ile Ser Tyr Leu Ile Pro Asp Leu Pro Lys Asp Leu Arg Asp 
865                 870                 875                 880 


Arg Met Arg Arg Glu Lys Tyr Leu Ile Gln Glu Met Met Tyr Glu Ala 
                885                 890                 895     


Glu Leu Glu Arg Leu Gln Lys Glu Arg Lys Glu Arg Lys Lys Asn Gly 
            900                 905                 910         


Lys Ala His His Asn Glu Trp Pro 
        915                 920 


<210>  6567
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  6567

Met Gly Asp Glu Asp Lys Arg Ile Thr Tyr Glu Asp Ser Glu Pro Ser 
1               5                   10                  15      


Thr Gly Met Asn Tyr Thr Pro Ser Met His Gln Glu Ala Gln Glu Glu 
            20                  25                  30          


Thr Val Met Lys Leu Lys Gly Ile Asp Ala Asn Glu Pro Thr Glu Gly 
        35                  40                  45              


Ser Ile Leu Leu Lys Ser Ser Glu Lys Lys Leu Gln Glu Thr Pro Thr 
    50                  55                  60                  


Glu Ala Asn His Val Gln Arg Leu Arg Gln Met Leu Ala Cys Pro Pro 
65                  70                  75                  80  


His Gly Leu Leu Asp Arg Val Ile Thr Asn Val Thr Ile Ile Val Leu 
                85                  90                  95      


Leu Trp Ala Val Val Trp Ser Ile Thr Gly Ser Glu Cys Leu Pro Gly 
            100                 105                 110         


Gly Asn Leu Phe Gly Ile Ile Ile Leu Phe Tyr Cys Ala Ile Ile Gly 
        115                 120                 125             


Gly Lys Leu Leu Gly Leu Ile Lys Leu Pro Thr Leu Pro Pro Leu Pro 
    130                 135                 140                 


Ser Leu Leu Gly Met Leu Leu Ala Gly Phe Leu Ile Arg Asn Ile Pro 
145                 150                 155                 160 


Val Ile Asn Asp Asn Val Gln Ile Lys His Lys Trp Ser Ser Ser Leu 
                165                 170                 175     


Arg Ser Ile Ala Leu Ser Ile Ile Leu Val Arg Ala Gly Leu Gly Leu 
            180                 185                 190         


Asp Ser Lys Ala Leu Lys Lys Leu Lys Gly Val Cys Val Arg Leu Ser 
        195                 200                 205             


Met Gly Pro Cys Ile Val Glu Ala Cys Thr Ser Ala Leu Leu Ala His 
    210                 215                 220                 


Tyr Leu Leu Gly Leu Pro Trp Gln Trp Gly Phe Ile Leu Gly Phe Val 
225                 230                 235                 240 


Leu Gly Ala Val Ser Pro Ala Val Val Val Pro Ser Met Leu Leu Leu 
                245                 250                 255     


Gln Gly Gly Gly Tyr Gly Val Glu Lys Gly Val Pro Thr Leu Leu Met 
            260                 265                 270         


Ala Ala Gly Ser Phe Asp Asp Ile Leu Ala Ile Thr Gly Phe Asn Thr 
        275                 280                 285             


Cys Leu Gly Ile Ala Phe Ser Thr Gly Ser Thr Val Phe Asn Val Leu 
    290                 295                 300                 


Arg Gly Val Leu Glu Val Val Ile Gly Val Ala Thr Gly Ser Val Leu 
305                 310                 315                 320 


Gly Phe Phe Ile Gln Tyr Phe Pro Ser Arg Asp Gln Asp Lys Leu Val 
                325                 330                 335     


Cys Lys Arg Thr Phe Leu Val Leu Gly Leu Ser Val Leu Ala Val Phe 
            340                 345                 350         


Ser Ser Val His Phe Gly Phe Pro Gly Ser Gly Gly Leu Cys Thr Leu 
        355                 360                 365             


Val Met Ala Phe Leu Ala Gly Met Gly Trp Thr Ser Glu Lys Ala Glu 
    370                 375                 380                 


Val Glu Lys Ile Ile Ala Val Ala Trp Asp Ile Phe Gln Pro Leu Leu 
385                 390                 395                 400 


Phe Gly Leu Ile Gly Ala Glu Val Ser Ile Ala Ser Leu Arg Pro Glu 
                405                 410                 415     


Thr Val Gly Leu Cys Val Ala Thr Val Gly Ile Ala Val Leu Ile Arg 
            420                 425                 430         


Ile Leu Thr Thr Phe Leu Met Val Cys Phe Ala Gly Phe Asn Leu Lys 
        435                 440                 445             


Glu Lys Ile Phe Ile Ser Phe Ala Trp Leu Pro Lys Ala Thr Val Gln 
    450                 455                 460                 


Ala Ala Ile Gly Ser Val Ala Leu Asp Thr Ala Arg Ser His Gly Glu 
465                 470                 475                 480 


Lys Gln Leu Glu Asp Tyr Gly Met Asp Val Leu Thr Val Ala Phe Leu 
                485                 490                 495     


Ser Ile Leu Ile Thr Ala Pro Ile Gly Ser Leu Leu Ile Gly Leu Leu 
            500                 505                 510         


Gly Pro Arg Leu Leu Gln Lys Val Glu His Gln Asn Lys Asp Glu Glu 
        515                 520                 525             


Val Gln Gly Glu Thr Ser Val Gln Val 
    530                 535         


<210>  6568
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  6568

Met Arg Pro Gly Thr Ala Leu Gln Ala Val Leu Leu Ala Val Leu Leu 
1               5                   10                  15      


Val Gly Leu Arg Ala Ala Thr Gly Arg Leu Leu Ser Gly Gln Pro Val 
            20                  25                  30          


Cys Arg Gly Gly Thr Gln Arg Pro Cys Tyr Lys Val Ile Tyr Phe His 
        35                  40                  45              


Asp Thr Ser Arg Arg Leu Asn Phe Glu Glu Ala Lys Glu Ala Cys Arg 
    50                  55                  60                  


Arg Asp Gly Gly Gln Leu Val Ser Ile Glu Ser Glu Asp Glu Gln Lys 
65                  70                  75                  80  


Leu Ile Glu Lys Phe Ile Glu Asn Leu Leu Pro Ser Asp Gly Asp Phe 
                85                  90                  95      


Trp Ile Gly Leu Arg Arg Arg Glu Glu Lys Gln Ser Asn Ser Thr Ala 
            100                 105                 110         


Cys Gln Asp Leu Tyr Ala Trp Thr Asp Gly Ser Ile Ser Gln Phe Arg 
        115                 120                 125             


Asn Trp Tyr Val Asp Glu Pro Ser Cys Gly Ser Glu Val Cys Val Val 
    130                 135                 140                 


Met Tyr His Gln Pro Ser Ala Pro Ala Gly Ile Gly Gly Pro Tyr Met 
145                 150                 155                 160 


Phe Gln Trp Asn Asp Asp Arg Cys Asn Met Lys Asn Asn Phe Ile Cys 
                165                 170                 175     


Lys Tyr Ser Asp Glu Lys Pro Ala Val Pro Ser Arg Glu Ala Glu Gly 
            180                 185                 190         


Glu Glu Thr Glu Leu Thr Thr Pro Val Leu Pro Glu Glu Thr Gln Glu 
        195                 200                 205             


Glu Asp Ala Lys Lys Thr Phe Lys Glu Ser Arg Glu Ala Ala Leu Asn 
    210                 215                 220                 


Leu Ala Tyr Ile Leu Ile Pro Ser Ile Pro Leu Leu Leu Leu Leu Val 
225                 230                 235                 240 


Val Thr Thr Val Val Cys Trp Val Trp Ile Cys Arg Lys Arg Lys Arg 
                245                 250                 255     


Glu Gln Pro Asp Pro Ser Thr Lys Lys Gln His Thr Ile Trp Pro Ser 
            260                 265                 270         


Pro His Gln Gly Asn Ser Pro Asp Leu Glu Val Tyr Asn Val Ile Arg 
        275                 280                 285             


Lys Gln Ser Glu Ala Asp Leu Ala Glu Thr Arg Pro Asp Leu Lys Asn 
    290                 295                 300                 


Ile Ser Phe Arg Val Cys Ser Gly Glu Ala Thr Pro Asp Asp Met Ser 
305                 310                 315                 320 


Cys Asp Tyr Asp Asn Met Ala Val Asn Pro Ser Glu Ser Gly Phe Val 
                325                 330                 335     


Thr Leu Val Ser Val Glu Ser Gly Phe Val Thr Asn Asp Ile Tyr Glu 
            340                 345                 350         


Phe Ser Pro Asp Gln Met Gly Arg Ser Lys Glu Ser Gly Trp Val Glu 
        355                 360                 365             


Asn Glu Ile Tyr Gly Tyr 
    370                 


<210>  6569
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  6569

Met Gly Arg Leu Ser Trp Gln Val Ala Ala Ala Ala Ala Val Gly Leu 
1               5                   10                  15      


Ala Leu Thr Leu Glu Ala Leu Pro Trp Val Leu Arg Trp Leu Arg Ser 
            20                  25                  30          


Arg Arg Arg Arg Pro Arg Arg Glu Ala Leu Phe Phe Pro Ser Gln Val 
        35                  40                  45              


Thr Cys Thr Glu Ala Leu Leu Arg Ala Pro Gly Ala Glu Leu Ala Glu 
    50                  55                  60                  


Leu Pro Glu Gly Cys Pro Cys Gly Leu Pro His Gly Glu Ser Ala Leu 
65                  70                  75                  80  


Ser Arg Leu Leu Arg Ala Leu Leu Ala Ala Arg Ala Ser Leu Asp Leu 
                85                  90                  95      


Cys Leu Phe Ala Phe Ser Ser Pro Gln Leu Gly Arg Ala Val Gln Leu 
            100                 105                 110         


Leu His Gln Arg Gly Val Arg Val Arg Val Val Thr Asp Cys Asp Tyr 
        115                 120                 125             


Met Ala Leu Asn Gly Ser Gln Ile Gly Leu Leu Arg Lys Ala Gly Ile 
    130                 135                 140                 


Gln Val Arg His Asp Gln Asp Pro Gly Tyr Met His His Lys Phe Ala 
145                 150                 155                 160 


Ile Val Asp Lys Arg Val Leu Ile Thr Gly Ser Leu Asn Trp Thr Thr 
                165                 170                 175     


Gln Ala Ile Gln Asn Asn Arg Glu Asn Val Leu Ile Thr Glu Asp Asp 
            180                 185                 190         


Glu Tyr Val Arg Leu Phe Leu Glu Glu Phe Glu Arg Ile Trp Glu Gln 
        195                 200                 205             


Phe Asn Pro Thr Lys Tyr Thr Phe Phe Pro Pro Lys Lys Ser His Gly 
    210                 215                 220                 


Ser Cys Ala Pro Pro Val Ser Arg Ala Gly Gly Arg Leu Leu Ser Trp 
225                 230                 235                 240 


His Arg Thr Cys Gly Thr Ser Ser Glu Ser Gln Thr 
                245                 250         


<210>  6570
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  6570

Met Asp Phe Leu Leu Leu Gly Leu Cys Leu Tyr Trp Leu Leu Arg Arg 
1               5                   10                  15      


Pro Ser Gly Val Val Leu Cys Leu Leu Gly Ala Cys Phe Gln Met Leu 
            20                  25                  30          


Pro Ala Ala Pro Ser Gly Cys Pro Gln Leu Cys Arg Cys Glu Gly Arg 
        35                  40                  45              


Leu Leu Tyr Cys Glu Ala Leu Asn Leu Thr Glu Ala Pro His Asn Leu 
    50                  55                  60                  


Ser Gly Leu Leu Gly Leu Ser Leu Arg Tyr Asn Ser Leu Ser Glu Leu 
65                  70                  75                  80  


Arg Ala Gly Gln Phe Thr Gly Leu Met Gln Leu Thr Trp Leu Tyr Leu 
                85                  90                  95      


Asp His Asn His Ile Cys Ser Val Gln Gly Asp Ala Phe Gln Lys Leu 
            100                 105                 110         


Arg Arg Val Lys Glu Leu Thr Leu Ser Ser Asn Gln Ile Thr Gln Leu 
        115                 120                 125             


Pro Asn Thr Thr Phe Arg Pro Met Pro Asn Leu Arg Ser Val Asp Leu 
    130                 135                 140                 


Ser Tyr Asn Lys Leu Gln Ala Leu Ala Pro Asp Leu Phe His Gly Leu 
145                 150                 155                 160 


Arg Lys Leu Thr Thr Leu His Met Arg Ala Asn Ala Ile Gln Phe Val 
                165                 170                 175     


Pro Val Arg Ile Phe Gln Asp Cys Arg Ser Leu Lys Phe Leu Asp Ile 
            180                 185                 190         


Gly Tyr Asn Gln Leu Lys Ser Leu Ala Arg Asn Ser Phe Ala Gly Leu 
        195                 200                 205             


Phe Lys Leu Thr Glu Leu His Leu Glu His Asn Asp Leu Val Lys Val 
    210                 215                 220                 


Asn Phe Ala His Phe Pro Arg Leu Ile Ser Leu His Ser Leu Cys Leu 
225                 230                 235                 240 


Arg Arg Asn Lys Val Ala Ile Val Val Ser Ser Leu Asp Trp Val Trp 
                245                 250                 255     


Asn Leu Glu Lys Met Asp Leu Ser Gly Asn Glu Ile Glu Tyr Met Glu 
            260                 265                 270         


Pro His Val Phe Glu Thr Val Pro His Leu Gln Ser Leu Gln Leu Asp 
        275                 280                 285             


Ser Asn Arg Leu Thr Tyr Ile Glu Pro Arg Ile Leu Asn Ser Trp Lys 
    290                 295                 300                 


Ser Leu Thr Ser Ile Thr Leu Ala Gly Asn Leu Trp Asp Cys Gly Arg 
305                 310                 315                 320 


Asn Val Cys Ala Leu Ala Ser Trp Leu Asn Asn Phe Gln Gly Arg Tyr 
                325                 330                 335     


Asp Gly Asn Leu Gln Cys Ala Ser Pro Glu Tyr Ala Gln Gly Glu Asp 
            340                 345                 350         


Val Leu Asp Ala Val Tyr Ala Phe His Leu Cys Glu Asp Gly Ala Glu 
        355                 360                 365             


Pro Thr Ser Gly His Leu Leu Ser Ala Val Thr Asn Arg Ser Asp Leu 
    370                 375                 380                 


Gly Pro Pro Ala Ser Ser Ala Thr Thr Leu Ala Asp Gly Gly Glu Gly 
385                 390                 395                 400 


Gln His Asp Gly Thr Phe Glu Pro Ala Thr Val Ala Leu Pro Gly Gly 
                405                 410                 415     


Glu His Ala Glu Asn Ala Val Gln Ile His Lys Val Val Thr Gly Thr 
            420                 425                 430         


Met Ala Leu Ile Phe Ser Phe Leu Ile Val Val Leu Val Leu Tyr Val 
        435                 440                 445             


Ser Trp Lys Cys Phe Pro Ala Ser Leu Arg Gln Leu Arg Gln Cys Phe 
    450                 455                 460                 


Val Thr Gln Arg Arg Lys Gln Lys Gln Lys Gln Thr Met His Gln Met 
465                 470                 475                 480 


Ala Ala Met Ser Ala Gln Glu Tyr Tyr Val Asp Tyr Lys Pro Asn His 
                485                 490                 495     


Ile Glu Gly Ala Leu Val Ile Ile Asn Glu Tyr Gly Ser Cys Thr Cys 
            500                 505                 510         


His Gln Gln Pro Ala Arg Glu Cys Glu Val 
        515                 520         


<210>  6571
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  6571

Met Phe Trp Thr Phe Lys Glu Trp Phe Trp Leu Glu Arg Phe Trp Leu 
1               5                   10                  15      


Pro Pro Thr Ile Lys Trp Ser Asp Leu Glu Asp His Asp Gly Leu Val 
            20                  25                  30          


Phe Val Lys Pro Ser His Leu Tyr Val Thr Ile Pro Tyr Ala Phe Leu 
        35                  40                  45              


Leu Leu Ile Ile Arg Arg Val Phe Glu Lys Phe Val Ala Ser Pro Leu 
    50                  55                  60                  


Ala Lys Ser Phe Gly Ile Lys Glu Thr Val Arg Lys Val Thr Pro Asn 
65                  70                  75                  80  


Thr Val Leu Glu Asn Phe Phe Lys His Ser Thr Arg Gln Pro Leu Gln 
                85                  90                  95      


Thr Asp Ile Tyr Gly Leu Ala Lys Lys Cys Asn Leu Thr Glu Arg Gln 
            100                 105                 110         


Val Glu Arg Trp Phe Arg Ser Arg Arg Asn Gln Glu Arg Pro Ser Arg 
        115                 120                 125             


Leu Lys Lys Phe Gln Glu Ala Cys Trp Arg Phe Ala Phe Tyr Leu Met 
    130                 135                 140                 


Ile Thr Val Ala Gly Ile Ala Phe Leu Tyr Asp Lys Pro Trp Leu Tyr 
145                 150                 155                 160 


Asp Leu Trp Glu Val Trp Asn Gly Tyr Pro Lys Gln Pro Leu Leu Pro 
                165                 170                 175     


Ser Gln Tyr Trp Tyr Tyr Ile Leu Glu Met Ser Phe Tyr Trp Ser Leu 
            180                 185                 190         


Leu Phe Arg Leu Gly Phe Asp Val Lys Arg Lys Asp Phe Leu Ala His 
        195                 200                 205             


Ile Ile His His Leu Ala Ala Ile Ser Leu Met Ser Phe Ser Trp Cys 
    210                 215                 220                 


Ala Asn Tyr Ile Arg Ser Gly Thr Leu Val Met Ile Val His Asp Val 
225                 230                 235                 240 


Ala Asp Ile Trp Leu Glu Ser Ala Lys Met Phe Ser Tyr Ala Gly Trp 
                245                 250                 255     


Thr Gln Thr Cys Asn Thr Leu Phe Phe Ile Phe Ser Thr Ile Phe Phe 
            260                 265                 270         


Ile Ser Arg Leu Ile Val Phe Pro Phe Trp Ile Leu Tyr Cys Thr Leu 
        275                 280                 285             


Ile Leu Pro Met Tyr His Leu Glu Pro Phe Phe Ser Tyr Ile Phe Leu 
    290                 295                 300                 


Asn Leu Gln Leu Met Ile Leu Gln Val Leu His Leu Tyr Trp Gly Tyr 
305                 310                 315                 320 


Tyr Ile Leu Lys Met Leu Asn Arg Cys Ile Phe Met Lys Ser Ile Gln 
                325                 330                 335     


Asp Val Arg Ser Asp Asp Glu Asp Tyr Glu Glu Glu Glu Glu Glu Glu 
            340                 345                 350         


Glu Glu Glu Ala Thr Lys Gly Lys Glu Met Asp Cys Leu Lys Asn Gly 
        355                 360                 365             


Leu Arg Ala Glu Arg His Leu Ile Pro Asn Gly Gln His Gly His 
    370                 375                 380             


<210>  6572
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  6572

Met Glu Ala Asp Leu Ser Gly Phe Asn Ile Asp Ala Pro Arg Trp Asp 
1               5                   10                  15      


Gln Arg Thr Phe Leu Gly Arg Val Lys His Phe Leu Asn Ile Thr Asp 
            20                  25                  30          


Pro Arg Thr Val Phe Val Ser Glu Arg Glu Leu Asp Trp Ala Lys Val 
        35                  40                  45              


Met Val Glu Lys Ser Arg Met Gly Val Val Pro Pro Gly Thr Gln Val 
    50                  55                  60                  


Glu Gln Leu Leu Tyr Ala Lys Lys Leu Tyr Asp Ser Ala Phe His Pro 
65                  70                  75                  80  


Asp Thr Gly Glu Lys Met Asn Val Ile Gly Arg Met Ser Phe Gln Leu 
                85                  90                  95      


Pro Gly Gly Met Ile Ile Thr Gly Phe Met Leu Gln Phe Tyr Arg Thr 
            100                 105                 110         


Met Pro Ala Val Ile Phe Trp Gln Trp Val Asn Gln Ser Phe Asn Ala 
        115                 120                 125             


Leu Val Asn Tyr Thr Asn Arg Asn Ala Ala Ser Pro Thr Ser Val Arg 
    130                 135                 140                 


Gln Met Ala Leu Ser Tyr Phe Thr Ala Thr Thr Thr Ala Val Ala Thr 
145                 150                 155                 160 


Ala Val Gly Met Asn Met Leu Thr Lys Lys Ala Pro Pro Leu Val Gly 
                165                 170                 175     


Arg Trp Val Pro Phe Ala Ala Val Ala Ala Ala Asn Cys Val Asn Ile 
            180                 185                 190         


Pro Met Met Arg Gln Gln Glu Leu Ile Lys Gly Ile Cys Val Lys Asp 
        195                 200                 205             


Arg Asn Glu Asn Glu Ile Gly His Ser Arg Arg Ala Ala Ala Ile Gly 
    210                 215                 220                 


Ile Thr Gln Val Val Ile Ser Arg Ile Thr Met Ser Ala Pro Gly Met 
225                 230                 235                 240 


Ile Leu Leu Pro Val Ile Met Glu Arg Leu Glu Lys Leu His Phe Met 
                245                 250                 255     


Gln Lys Val Lys Val Leu His Ala Pro Leu Gln Val Met Leu Ser Gly 
            260                 265                 270         


Cys Phe Leu Ile Phe Met Val Pro Val Ala Cys Gly Leu Phe Pro Gln 
        275                 280                 285             


Lys Cys Glu Leu Pro Val Ser Tyr Leu Glu Pro Lys Leu Gln Asp Thr 
    290                 295                 300                 


Ile Lys Ala Lys Tyr Gly Glu Leu Glu Pro Tyr Val Tyr Phe Asn Lys 
305                 310                 315                 320 


Gly Leu 
        


<210>  6573
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  6573

Met Glu His Ser Glu Gly Ala Pro Gly Asp Pro Ala Gly Thr Val Val 
1               5                   10                  15      


Pro Gln Glu Leu Leu Glu Glu Met Leu Trp Phe Phe Arg Val Glu Asp 
            20                  25                  30          


Ala Ser Pro Trp Asn His Ser Ile Leu Ala Leu Ala Ala Val Val Val 
        35                  40                  45              


Ile Ile Ser Met Val Leu Leu Gly Arg Ser Ile Gln Ala Ser Arg Lys 
    50                  55                  60                  


Glu Lys Met Gln Pro Pro Glu Lys Glu Thr Pro Glu Val Leu His Leu 
65                  70                  75                  80  


Asp Glu Ala Lys Asp His Asn Ser Leu Asn Asn Leu Arg Glu Thr Leu 
                85                  90                  95      


Leu Ser Glu Lys Pro Asn Leu Ala Gln Val Glu Leu Glu Leu Lys Glu 
            100                 105                 110         


Arg Asp Val Leu Ser Val Phe Leu Pro Asp Val Pro Glu Thr Glu Ser 
        115                 120                 125             


<210>  6574
<211>  994
<212>  PRT
<213>  Homo sapiens

<400>  6574

Met Arg Pro Val Ala Leu Leu Leu Leu Pro Ser Leu Leu Ala Leu Leu 
1               5                   10                  15      


Ala His Gly Leu Ser Leu Glu Ala Pro Thr Val Gly Lys Gly Gln Ala 
            20                  25                  30          


Pro Gly Ile Glu Glu Thr Asp Gly Glu Leu Thr Ala Ala Pro Thr Pro 
        35                  40                  45              


Glu Gln Pro Glu Arg Gly Val His Phe Val Thr Thr Ala Pro Thr Leu 
    50                  55                  60                  


Lys Leu Leu Asn His His Pro Leu Leu Glu Glu Phe Leu Gln Glu Gly 
65                  70                  75                  80  


Leu Glu Lys Gly Asp Glu Glu Leu Arg Pro Ala Leu Pro Phe Gln Pro 
                85                  90                  95      


Asp Pro Pro Ala Pro Phe Thr Pro Ser Pro Leu Pro Arg Leu Ala Asn 
            100                 105                 110         


Gln Asp Ser Arg Pro Val Phe Thr Ser Pro Thr Pro Ala Met Ala Ala 
        115                 120                 125             


Val Pro Thr Gln Pro Gln Ser Lys Glu Gly Pro Trp Ser Pro Glu Ser 
    130                 135                 140                 


Glu Ser Pro Met Leu Arg Ile Thr Ala Pro Leu Pro Pro Gly Pro Ser 
145                 150                 155                 160 


Met Ala Val Pro Thr Leu Gly Pro Gly Glu Ile Ala Ser Thr Thr Pro 
                165                 170                 175     


Pro Ser Arg Ala Trp Thr Pro Thr Gln Glu Gly Pro Gly Asp Met Gly 
            180                 185                 190         


Arg Pro Trp Val Ala Glu Val Val Ser Gln Gly Ala Gly Ile Gly Ile 
        195                 200                 205             


Gln Gly Thr Ile Thr Ser Ser Thr Ala Ser Gly Asp Asp Glu Glu Thr 
    210                 215                 220                 


Thr Thr Thr Thr Thr Ile Ile Thr Thr Thr Ile Thr Thr Val Gln Thr 
225                 230                 235                 240 


Pro Gly Pro Cys Ser Trp Asn Phe Ser Gly Pro Glu Gly Ser Leu Asp 
                245                 250                 255     


Ser Pro Thr Asp Leu Ser Ser Pro Thr Asp Val Gly Leu Asp Cys Phe 
            260                 265                 270         


Phe Tyr Ile Ser Val Tyr Pro Gly Tyr Gly Val Glu Ile Lys Val Gln 
        275                 280                 285             


Asn Ile Ser Leu Arg Glu Gly Glu Thr Val Thr Val Glu Gly Leu Gly 
    290                 295                 300                 


Gly Pro Asp Pro Leu Pro Leu Ala Asn Gln Ser Phe Leu Leu Arg Gly 
305                 310                 315                 320 


Gln Val Ile Arg Ser Pro Thr His Gln Ala Ala Leu Arg Phe Gln Ser 
                325                 330                 335     


Leu Pro Pro Pro Ala Gly Pro Gly Thr Phe His Phe His Tyr Gln Ala 
            340                 345                 350         


Tyr Leu Leu Ser Cys His Phe Pro Arg Arg Pro Ala Tyr Gly Asp Val 
        355                 360                 365             


Thr Val Thr Ser Leu His Pro Gly Gly Ser Ala Arg Phe His Cys Ala 
    370                 375                 380                 


Thr Gly Tyr Gln Leu Lys Gly Ala Arg His Leu Thr Cys Leu Asn Ala 
385                 390                 395                 400 


Thr Gln Pro Phe Trp Asp Ser Lys Glu Pro Val Cys Ile Ala Ala Cys 
                405                 410                 415     


Gly Gly Val Ile Arg Asn Ala Thr Thr Gly Arg Ile Val Ser Pro Gly 
            420                 425                 430         


Phe Pro Gly Asn Tyr Ser Asn Asn Leu Thr Cys His Trp Leu Leu Glu 
        435                 440                 445             


Ala Pro Glu Gly Gln Arg Leu His Leu His Phe Glu Lys Val Ser Leu 
    450                 455                 460                 


Ala Glu Asp Asp Asp Arg Leu Ile Ile Arg Asn Gly Asp Asn Val Glu 
465                 470                 475                 480 


Ala Pro Pro Val Tyr Asp Ser Tyr Glu Val Glu Tyr Leu Pro Ile Glu 
                485                 490                 495     


Gly Leu Leu Ser Ser Gly Lys His Phe Phe Val Glu Leu Ser Thr Asp 
            500                 505                 510         


Ser Ser Gly Ala Ala Ala Gly Met Ala Leu Arg Tyr Glu Ala Phe Gln 
        515                 520                 525             


Gln Gly His Cys Tyr Glu Pro Phe Val Lys Tyr Gly Asn Phe Ser Ser 
    530                 535                 540                 


Ser Thr Pro Thr Tyr Pro Val Gly Thr Thr Val Glu Phe Ser Cys Asp 
545                 550                 555                 560 


Pro Gly Tyr Thr Leu Glu Gln Gly Ser Ile Ile Ile Glu Cys Val Asp 
                565                 570                 575     


Pro His Asp Pro Gln Trp Asn Glu Thr Glu Pro Ala Cys Arg Ala Val 
            580                 585                 590         


Cys Ser Gly Glu Ile Thr Asp Ser Ala Gly Val Val Leu Ser Pro Asn 
        595                 600                 605             


Trp Pro Glu Pro Tyr Gly Arg Gly Gln Asp Cys Ile Trp Gly Val His 
    610                 615                 620                 


Val Glu Glu Asp Lys Arg Ile Met Leu Asp Ile Arg Val Leu Arg Ile 
625                 630                 635                 640 


Gly Pro Gly Asp Val Leu Thr Phe Tyr Asp Gly Asp Asp Leu Thr Ala 
                645                 650                 655     


Arg Val Leu Gly Gln Tyr Ser Gly Pro Arg Ser His Phe Lys Leu Phe 
            660                 665                 670         


Thr Ser Met Ala Asp Val Thr Ile Gln Phe Gln Ser Asp Pro Gly Thr 
        675                 680                 685             


Ser Val Leu Gly Tyr Gln Gln Gly Phe Val Ile His Phe Phe Glu Val 
    690                 695                 700                 


Pro Arg Asn Asp Thr Cys Pro Glu Leu Pro Glu Ile Pro Asn Gly Trp 
705                 710                 715                 720 


Lys Ser Pro Ser Gln Pro Glu Leu Val His Gly Thr Val Val Thr Tyr 
                725                 730                 735     


Gln Cys Tyr Pro Gly Tyr Gln Val Val Gly Ser Ser Val Leu Met Cys 
            740                 745                 750         


Gln Trp Asp Leu Thr Trp Ser Glu Asp Leu Pro Ser Cys Gln Arg Val 
        755                 760                 765             


Thr Ser Cys His Asp Pro Gly Asp Val Glu His Ser Arg Arg Leu Ile 
    770                 775                 780                 


Ser Ser Pro Lys Phe Pro Val Gly Ala Thr Val Gln Tyr Ile Cys Asp 
785                 790                 795                 800 


Gln Gly Phe Val Leu Met Gly Ser Ser Ile Leu Thr Cys His Asp Arg 
                805                 810                 815     


Gln Ala Gly Ser Pro Lys Trp Ser Asp Arg Ala Pro Lys Cys Leu Leu 
            820                 825                 830         


Glu Gln Leu Lys Pro Cys His Gly Leu Ser Ala Pro Glu Asn Gly Ala 
        835                 840                 845             


Arg Ser Pro Glu Lys Gln Leu His Pro Ala Gly Ala Thr Ile His Phe 
    850                 855                 860                 


Ser Cys Ala Pro Gly Tyr Val Leu Lys Gly Gln Ala Ser Ile Lys Cys 
865                 870                 875                 880 


Val Pro Gly His Pro Ser His Trp Ser Asp Pro Pro Pro Ile Cys Arg 
                885                 890                 895     


Ala Ala Ser Leu Asp Gly Phe Tyr Asn Ser Arg Ser Leu Asp Val Ala 
            900                 905                 910         


Lys Ala Pro Ala Ala Ser Ser Thr Leu Asp Ala Ala His Ile Ala Ala 
        915                 920                 925             


Ala Ile Phe Leu Pro Leu Val Ala Met Val Leu Leu Val Gly Gly Val 
    930                 935                 940                 


Tyr Phe Tyr Phe Ser Arg Leu Gln Gly Lys Ser Ser Leu Gln Leu Pro 
945                 950                 955                 960 


Arg Pro Arg Pro Arg Pro Tyr Asn Arg Ile Thr Ile Glu Ser Ala Phe 
                965                 970                 975     


Asp Asn Pro Thr Tyr Glu Thr Gly Ser Leu Ser Phe Ala Gly Asp Glu 
            980                 985                 990         


Arg Ile 
        


<210>  6575
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  6575

Met Gly Ala Cys Leu Gly Ala Cys Ser Leu Leu Ser Cys Ala Ser Cys 
1               5                   10                  15      


Leu Cys Gly Ser Ala Pro Cys Ile Leu Cys Ser Cys Cys Pro Ala Ser 
            20                  25                  30          


Arg Asn Ser Thr Val Ser Arg Leu Ile Phe Thr Phe Phe Leu Phe Leu 
        35                  40                  45              


Gly Val Leu Val Ser Ile Ile Met Leu Ser Pro Gly Val Glu Ser Gln 
    50                  55                  60                  


Leu Tyr Lys Leu Pro Trp Val Cys Glu Glu Gly Ala Gly Ile Pro Thr 
65                  70                  75                  80  


Val Leu Gln Gly His Ile Asp Cys Gly Ser Leu Leu Gly Tyr Arg Ala 
                85                  90                  95      


Val Tyr Arg Met Cys Phe Ala Thr Ala Ala Phe Phe Phe Phe Phe Thr 
            100                 105                 110         


Leu Leu Met Leu Cys Val Ser Ser Ser Arg Asp Pro Arg Ala Ala Ile 
        115                 120                 125             


Gln Asn Gly Phe Trp Phe Phe Lys Phe Leu Ile Leu Val Gly Leu Thr 
    130                 135                 140                 


Val Gly Ala Phe Tyr Ile Pro Asp Gly Ser Phe Thr Asn Ile Trp Phe 
145                 150                 155                 160 


Tyr Phe Gly Val Val Gly Ser Phe Leu Phe Ile Leu Ile Gln Leu Val 
                165                 170                 175     


Leu Leu Ile Asp Phe Ala His Ser Trp Asn Gln Arg Trp Leu Gly Lys 
            180                 185                 190         


Ala Glu Glu Cys Asp Ser Arg Ala Trp Tyr Ala Gly Leu Phe Phe Phe 
        195                 200                 205             


Thr Leu Leu Phe Tyr Leu Leu Ser Ile Ala Ala Val Ala Leu Met Phe 
    210                 215                 220                 


Met Tyr Tyr Thr Glu Pro Ser Gly Cys His Glu Gly Lys Val Phe Ile 
225                 230                 235                 240 


Ser Leu Asn Leu Thr Phe Cys Val Cys Val Ser Ile Ala Ala Val Leu 
                245                 250                 255     


Pro Lys Val Gln Asp Ala Gln Pro Asn Ser Gly Leu Leu Gln Ala Ser 
            260                 265                 270         


Val Ile Thr Leu Tyr Thr Met Phe Val Thr Trp Ser Ala Leu Ser Ser 
        275                 280                 285             


Ile Pro Glu Gln Lys Cys Asn Pro His Leu Pro Thr Gln Leu Gly Asn 
    290                 295                 300                 


Glu Thr Val Val Ala Gly Pro Glu Gly Tyr Glu Thr Gln Trp Trp Asp 
305                 310                 315                 320 


Ala Pro Ser Ile Val Gly Leu Ile Ile Phe Leu Leu Cys Thr Leu Phe 
                325                 330                 335     


Ile Ser Leu Arg Ser Ser Asp His Arg Gln Val Asn Ser Leu Met Gln 
            340                 345                 350         


Thr Glu Glu Cys Pro Pro Met Leu Asp Ala Thr Gln Gln Gln Gln Gln 
        355                 360                 365             


Val Ala Ala Cys Glu Gly Arg Ala Phe Asp Asn Glu Gln Asp Gly Val 
    370                 375                 380                 


Thr Tyr Ser Tyr Ser Phe Phe His Phe Cys Leu Val Leu Ala Ser Leu 
385                 390                 395                 400 


His Val Met Met Thr Leu Thr Asn Trp Tyr Lys Pro Gly Glu Thr Arg 
                405                 410                 415     


Lys Met Ile Ser Thr Trp Thr Ala Val Trp Val Lys Ile Cys Ala Ser 
            420                 425                 430         


Trp Ala Gly Leu Leu Leu Tyr Leu Trp Thr Leu Val Ala Pro Leu Leu 
        435                 440                 445             


Leu Arg Asn Arg Asp Phe Ser 
    450                 455 


<210>  6576
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  6576

Met Glu Glu Pro Gln Arg Ala Arg Ser His Thr Val Thr Thr Thr Ala 
1               5                   10                  15      


Ser Ser Phe Ala Glu Asn Phe Ser Thr Ser Ser Ser Ser Phe Ala Tyr 
            20                  25                  30          


Asp Arg Glu Phe Leu Arg Thr Leu Pro Gly Phe Leu Ile Val Ala Glu 
        35                  40                  45              


Ile Val Leu Gly Leu Leu Val Trp Thr Leu Ile Ala Gly Thr Glu Tyr 
    50                  55                  60                  


Phe Arg Val Pro Ala Phe Gly Trp Val Met Phe Val Ala Val Phe Tyr 
65                  70                  75                  80  


Trp Val Leu Thr Val Phe Phe Leu Ile Ile Tyr Ile Thr Met Thr Tyr 
                85                  90                  95      


Thr Arg Ile Pro Gln Val Pro Trp Thr Thr Val Gly Leu Cys Phe Asn 
            100                 105                 110         


Gly Ser Ala Phe Val Leu Tyr Leu Ser Ala Ala Val Val Asp Ala Ser 
        115                 120                 125             


Ser Val Ser Pro Glu Arg Asp Ser His Asn Phe Asn Ser Trp Ala Ala 
    130                 135                 140                 


Ser Ser Phe Phe Ala Phe Leu Val Thr Ile Cys Tyr Ala Gly Asn Thr 
145                 150                 155                 160 


Tyr Phe Ser Phe Ile Ala Trp Arg Ser Arg Thr Ile Gln 
                165                 170             


<210>  6577
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  6577

Met Gly Gly Leu Arg Leu Leu Ala Val Ala Leu Thr Cys Cys Trp Trp 
1               5                   10                  15      


Pro Gln Gly Ser Gln Gly Lys Thr Leu Arg Gly Ser Phe Ser Ser Thr 
            20                  25                  30          


Ala Ala Gln Asp Ala Gln Gly Gln Arg Ile Gly His Phe Glu Phe His 
        35                  40                  45              


Gly Asp His Ala Leu Leu Cys Val Arg Ile Asn Asn Ile Ala Val Ala 
    50                  55                  60                  


Val Gly Lys Glu Ala Lys Leu Tyr Leu Phe Gln Ala Gln Glu Trp Leu 
65                  70                  75                  80  


Lys Leu Gln Gln Ser Ser His Gly Tyr Ser Cys Ser Glu Lys Leu Ser 
                85                  90                  95      


Lys Ala Gln Leu Thr Met Thr Met Asn Gln Thr Glu His Asn Leu Thr 
            100                 105                 110         


Val Ser Gln Ile Pro Ser Pro Gln Thr Trp His Val Phe Tyr Ala Asp 
        115                 120                 125             


Lys Tyr Thr Cys Gln Asp Asp Lys Glu Asn Ser Gln Val Glu Asp Ile 
    130                 135                 140                 


Pro Phe Glu Met Val Leu Leu Asn Pro Asp Ala Glu Gly Asn Pro Phe 
145                 150                 155                 160 


Asp His Phe Ser Ala Gly Glu Ser Gly Leu His Glu Phe Phe Phe Leu 
                165                 170                 175     


Leu Val Leu Val Tyr Phe Val Ile Ala Cys Ile Tyr Ala Gln Ser Leu 
            180                 185                 190         


Trp Gln Ala Ile Lys Lys Gly Gly Pro Met His Met Ile Leu Lys Val 
        195                 200                 205             


Leu Thr Thr Ala Leu Leu Leu Gln Ala Gly Ser Ala Leu Ala Asn Tyr 
    210                 215                 220                 


Ile His Phe Ser Ser Tyr Ser Lys Asp Gly Ile Gly Val Pro Phe Met 
225                 230                 235                 240 


Gly Ser Leu Ala Glu Phe Phe Asp Ile Ala Ser Gln Ile Gln Met Leu 
                245                 250                 255     


Tyr Leu Leu Leu Ser Leu Cys Met Gly Trp Thr Ile Val Arg Met Lys 
            260                 265                 270         


Lys Ser Gln Ser Arg Pro Leu Gln Trp Asp Ser Thr Pro Ala Ser Thr 
        275                 280                 285             


Gly Ile Ala Val Phe Ile Val Met Thr Gln Ser Val Leu Leu Leu Trp 
    290                 295                 300                 


Glu Gln Phe Glu Asp Ile Ser His His Ser Tyr His Ser His His Asn 
305                 310                 315                 320 


Leu Ala Gly Ile Leu Leu Ile Val Leu Arg Ile Cys Leu Ala Leu Ser 
                325                 330                 335     


Leu Gly Cys Gly Leu Tyr Gln Ile Ile Thr Val Glu Arg Ser Thr Leu 
            340                 345                 350         


Lys Arg Glu Phe Tyr Ile Thr Phe Ala Lys Gly Cys Ile Leu Trp Phe 
        355                 360                 365             


Leu Cys His Pro Val Leu Ala Cys Ile Ser Val Ile Phe Ser Asp Tyr 
    370                 375                 380                 


Gln Arg Asp Lys Val Ile Thr Ile Gly Val Ile Leu Cys Gln Ser Val 
385                 390                 395                 400 


Ser Met Val Ile Leu Tyr Arg Leu Phe Leu Ser His Ser Leu Tyr Trp 
                405                 410                 415     


Glu Val Ser Ser Leu Ser Ser Val Thr Leu Pro Leu Thr Ile Ser Ser 
            420                 425                 430         


Gly His Lys Ser Arg Pro His Phe 
        435                 440 


<210>  6578
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  6578

Met Met Ala Leu Trp Ser Leu Leu His Leu Thr Phe Leu Gly Phe Ser 
1               5                   10                  15      


Ile Thr Leu Leu Leu Val His Gly Gln Gly Phe Gln Gly Thr Ala Ala 
            20                  25                  30          


Ile Trp Pro Ser Leu Phe Asn Val Asn Leu Ser Lys Lys Val Gln Glu 
        35                  40                  45              


Ser Ile Gln Ile Pro Asn Asn Gly Ser Ala Pro Leu Leu Val Asp Val 
    50                  55                  60                  


Arg Val Phe Val Ser Asn Val Phe Asn Val Asp Ile Leu Arg Tyr Thr 
65                  70                  75                  80  


Met Ser Ser Met Leu Leu Leu Arg Leu Ser Trp Leu Asp Thr Arg Leu 
                85                  90                  95      


Ala Trp Asn Thr Ser Ala His Pro Arg His Ala Ile Thr Leu Pro Trp 
            100                 105                 110         


Glu Ser Leu Trp Thr Pro Arg Leu Thr Ile Leu Glu Ala Leu Trp Val 
        115                 120                 125             


Asp Trp Arg Asp Gln Ser Pro Gln Ala Arg Val Asp Gln Asp Gly His 
    130                 135                 140                 


Val Lys Leu Asn Leu Ala Leu Ala Thr Glu Thr Asn Cys Asn Phe Glu 
145                 150                 155                 160 


Leu Leu His Phe Pro Arg Asp His Ser Asn Cys Ser Leu Ser Phe Tyr 
                165                 170                 175     


Ala Leu Ser Asn Thr Ala Met Glu Leu Glu Phe Gln Ala His Val Val 
            180                 185                 190         


Asn Glu Ile Val Ser Val Lys Arg Glu Tyr Val Val Tyr Asp Leu Lys 
        195                 200                 205             


Thr Gln Val Pro Pro Gln Gln Leu Val Pro Cys Phe Gln Val Thr Leu 
    210                 215                 220                 


Arg Leu Lys Asn Thr Ala Leu Lys Ser Ile Ile Ala Leu Leu Val Pro 
225                 230                 235                 240 


Ala Glu Ala Leu Leu Leu Ala Asp Val Cys Gly Gly Leu Leu Pro Leu 
                245                 250                 255     


Arg Ala Ile Glu Arg Ile Gly Tyr Lys Val Thr Leu Leu Leu Ser Tyr 
            260                 265                 270         


Leu Val Leu His Ser Ser Leu Val Gln Ala Leu Pro Ser Ser Ser Ser 
        275                 280                 285             


Cys Asn Pro Leu Leu Ile Tyr Tyr Phe Thr Ile Leu Leu Leu Leu Leu 
    290                 295                 300                 


Phe Leu Ser Thr Ile Glu Thr Val Leu Leu Ala Gly Leu Leu Ala Arg 
305                 310                 315                 320 


Gly Asn Leu Gly Ala Lys Ser Gly Pro Ser Pro Ala Pro Arg Gly Glu 
                325                 330                 335     


Gln Arg Glu His Gly Asn Pro Gly Pro His Pro Ala Glu Glu Pro Ser 
            340                 345                 350         


Arg Gly Val Lys Gly Ser Gln Arg Ser Trp Pro Glu Thr Ala Asp Arg 
        355                 360                 365             


Ile Phe Phe Leu Val Tyr Val Val Gly Val Leu Cys Thr Gln Phe Val 
    370                 375                 380                 


Phe Ala Gly Ile Trp Met Trp Ala Ala Cys Lys Ser Asp Ala Ala Pro 
385                 390                 395                 400 


Gly Glu Ala Ala Pro His Gly Arg Arg Pro Arg Leu 
                405                 410         


<210>  6579
<211>  724
<212>  PRT
<213>  Homo sapiens

<400>  6579

Met Lys Ser Ala Lys Gly Ile Glu Asn Leu Ala Phe Val Pro Ser Ser 
1               5                   10                  15      


Pro Asp Ile Leu Arg Arg Leu Ser Ala Ser Pro Ser Gln Ile Glu Val 
            20                  25                  30          


Ser Ala Leu Ser Ser Asp Pro Gln Arg Glu Asn Ser Gln Pro Gln Glu 
        35                  40                  45              


Leu Gln Lys Pro Gln Glu Pro Gln Lys Ser Pro Glu Pro Ser Leu Pro 
    50                  55                  60                  


Ser Ala Pro Pro Asn Val Ser Glu Glu Lys Leu Arg Ser Leu Ser Leu 
65                  70                  75                  80  


Ser Glu Phe Glu Glu Gly Ser Tyr Gly Trp Arg Asn Phe His Pro Gln 
                85                  90                  95      


Cys Leu Gln Arg Cys Asn Thr Pro Gly Gly Phe Leu Leu His Tyr Cys 
            100                 105                 110         


Leu Leu Ala Val Thr Gln Gly Ile Val Val Asn Gly Leu Val Asn Ile 
        115                 120                 125             


Ser Ile Ser Thr Val Glu Lys Arg Tyr Glu Met Lys Ser Ser Leu Thr 
    130                 135                 140                 


Gly Leu Ile Ser Ser Ser Tyr Asp Ile Ser Phe Cys Leu Leu Ser Leu 
145                 150                 155                 160 


Phe Val Ser Phe Phe Gly Glu Arg Gly His Lys Pro Arg Trp Leu Ala 
                165                 170                 175     


Phe Ala Ala Phe Met Ile Gly Leu Gly Ala Leu Val Phe Ser Leu Pro 
            180                 185                 190         


Gln Phe Phe Ser Gly Glu Tyr Lys Leu Gly Ser Leu Phe Glu Asp Thr 
        195                 200                 205             


Cys Val Thr Thr Arg Asn Ser Thr Ser Cys Thr Ser Ser Thr Ser Ser 
    210                 215                 220                 


Leu Ser Asn Tyr Leu Tyr Val Phe Ile Leu Gly Gln Leu Leu Leu Gly 
225                 230                 235                 240 


Ala Gly Gly Thr Pro Leu Tyr Thr Leu Gly Thr Ala Phe Leu Asp Asp 
                245                 250                 255     


Ser Val Pro Thr His Lys Ser Ser Leu Tyr Ile Gly Thr Gly Tyr Ala 
            260                 265                 270         


Met Ser Ile Leu Gly Pro Ala Ile Gly Tyr Val Leu Gly Gly Gln Leu 
        275                 280                 285             


Leu Thr Ile Tyr Ile Asp Val Ala Met Gly Glu Ser Thr Asp Val Thr 
    290                 295                 300                 


Glu Asp Asp Pro Arg Trp Leu Gly Ala Trp Trp Ile Gly Phe Leu Leu 
305                 310                 315                 320 


Ser Trp Ile Phe Ala Trp Ser Leu Ile Ile Pro Phe Ser Cys Phe Pro 
                325                 330                 335     


Lys His Leu Pro Gly Thr Ala Glu Ile Gln Ala Gly Lys Thr Ser Gln 
            340                 345                 350         


Ala His Gln Ser Asn Ser Asn Ala Asp Val Lys Phe Gly Lys Ser Ile 
        355                 360                 365             


Lys Asp Phe Pro Ala Ala Leu Lys Asn Leu Met Lys Asn Ala Val Phe 
    370                 375                 380                 


Met Cys Leu Val Leu Ser Thr Ser Ser Glu Ala Leu Ile Thr Thr Gly 
385                 390                 395                 400 


Phe Ala Thr Phe Leu Pro Lys Phe Ile Glu Asn Gln Phe Gly Leu Thr 
                405                 410                 415     


Ser Ser Phe Ala Ala Thr Leu Gly Gly Ala Val Leu Ile Pro Gly Ala 
            420                 425                 430         


Ala Leu Gly Gln Ile Leu Gly Gly Phe Leu Val Ser Lys Phe Arg Met 
        435                 440                 445             


Thr Cys Lys Asn Thr Met Lys Phe Ala Leu Phe Thr Ser Gly Val Ala 
    450                 455                 460                 


Leu Thr Leu Ser Phe Val Phe Met Tyr Ala Lys Cys Glu Asn Glu Pro 
465                 470                 475                 480 


Phe Ala Gly Val Ser Glu Ser Tyr Asn Gly Thr Gly Glu Leu Gly Asn 
                485                 490                 495     


Leu Ile Ala Pro Cys Asn Ala Asn Cys Asn Cys Ser Arg Ser Tyr Tyr 
            500                 505                 510         


Tyr Pro Val Cys Gly Asp Gly Val Gln Tyr Phe Ser Pro Cys Phe Ala 
        515                 520                 525             


Gly Cys Ser Asn Pro Val Ala His Arg Lys Pro Lys Val Tyr Tyr Asn 
    530                 535                 540                 


Cys Ser Cys Ile Glu Arg Lys Thr Glu Ile Thr Ser Thr Ala Glu Thr 
545                 550                 555                 560 


Phe Gly Phe Glu Ala Lys Ala Gly Lys Cys Glu Thr His Cys Ala Lys 
                565                 570                 575     


Leu Pro Ile Phe Leu Cys Ile Phe Phe Ile Val Ile Ile Phe Thr Phe 
            580                 585                 590         


Met Ala Gly Thr Pro Ile Thr Val Ser Ile Leu Arg Cys Val Asn His 
        595                 600                 605             


Arg Gln Arg Ser Leu Ala Leu Gly Ile Gln Phe Met Val Leu Arg Leu 
    610                 615                 620                 


Leu Gly Thr Ile Pro Gly Pro Ile Ile Phe Gly Phe Thr Ile Asp Ser 
625                 630                 635                 640 


Thr Cys Ile Leu Trp Asp Ile Asn Asp Cys Gly Ile Lys Gly Ala Cys 
                645                 650                 655     


Trp Ile Tyr Asp Asn Ile Lys Met Ala His Met Leu Val Ala Ile Ser 
            660                 665                 670         


Val Thr Cys Lys Val Ile Thr Met Phe Phe Asn Gly Phe Ala Ile Phe 
        675                 680                 685             


Leu Tyr Lys Pro Pro Pro Ser Ala Thr Asp Val Ser Phe His Lys Glu 
    690                 695                 700                 


Asn Ala Val Val Thr Asn Val Leu Ala Glu Gln Asp Leu Asn Lys Ile 
705                 710                 715                 720 


Val Lys Glu Gly 
                


<210>  6580
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  6580

Met Pro Arg Gly Trp Ala Ala Pro Leu Leu Leu Leu Leu Leu Gln Gly 
1               5                   10                  15      


Gly Trp Gly Cys Pro Asp Leu Val Cys Tyr Thr Asp Tyr Leu Gln Thr 
            20                  25                  30          


Val Ile Cys Ile Leu Glu Met Trp Asn Leu His Pro Ser Thr Leu Thr 
        35                  40                  45              


Leu Thr Trp Gln Asp Gln Tyr Glu Glu Leu Lys Asp Glu Ala Thr Ser 
    50                  55                  60                  


Cys Ser Leu His Arg Ser Ala His Asn Ala Thr His Ala Thr Tyr Thr 
65                  70                  75                  80  


Cys His Met Asp Val Phe His Phe Met Ala Asp Asp Ile Phe Ser Val 
                85                  90                  95      


Asn Ile Thr Asp Gln Ser Gly Asn Tyr Ser Gln Glu Cys Gly Ser Phe 
            100                 105                 110         


Leu Leu Ala Glu Ser Ile Lys Pro Ala Pro Pro Phe Asn Val Thr Val 
        115                 120                 125             


Thr Phe Ser Gly Gln Tyr Asn Ile Ser Trp Arg Ser Asp Tyr Glu Asp 
    130                 135                 140                 


Pro Ala Phe Tyr Met Leu Lys Gly Lys Leu Gln Tyr Glu Leu Gln Tyr 
145                 150                 155                 160 


Arg Asn Arg Gly Asp Pro Trp Ala Val Ser Pro Arg Arg Lys Leu Ile 
                165                 170                 175     


Ser Val Asp Ser Arg Ser Val Ser Leu Leu Pro Leu Glu Phe Arg Lys 
            180                 185                 190         


Asp Ser Ser Tyr Glu Leu Gln Val Arg Ala Gly Pro Met Pro Gly Ser 
        195                 200                 205             


Ser Tyr Gln Gly Thr Trp Ser Glu Trp Ser Asp Pro Val Ile Phe Gln 
    210                 215                 220                 


Thr Gln Ser Glu Glu Leu Lys Glu Gly Trp Asn Pro His Leu Leu Leu 
225                 230                 235                 240 


Leu Leu Leu Leu Val Ile Val Phe Ile Pro Ala Phe Trp Ser Leu Lys 
                245                 250                 255     


Thr His Pro Leu Trp Arg Leu Trp Lys Lys Ile Trp Ala Val Pro Ser 
            260                 265                 270         


Pro Glu Arg Phe Phe Met Pro Leu Tyr Lys Gly Cys Ser Gly Asp Phe 
        275                 280                 285             


Lys Lys Trp Val Gly Ala Pro Phe Thr Gly Ser Ser Leu Glu Leu Gly 
    290                 295                 300                 


Pro Trp Ser Pro Glu Val Pro Ser Thr Leu Glu Val Tyr Ser Cys His 
305                 310                 315                 320 


Pro Pro Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr Glu Leu Gln Glu 
                325                 330                 335     


Pro Ala Glu Leu Val Glu Ser Asp Gly Val Pro Lys Pro Ser Phe Trp 
            340                 345                 350         


Pro Thr Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser Glu Glu Arg Asp 
        355                 360                 365             


Arg Pro Tyr Gly Leu Val Ser Ile Asp Thr Val Thr Val Leu Asp Ala 
    370                 375                 380                 


Glu Gly Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro 
385                 390                 395                 400 


Ala Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly Leu Glu Asp 
                405                 410                 415     


Pro Leu Leu Asp Ala Gly Thr Thr Val Leu Ser Cys Gly Cys Val Ser 
            420                 425                 430         


Ala Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser Leu Leu Asp Arg 
        435                 440                 445             


Leu Lys Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala Gly Gly Leu Pro 
    450                 455                 460                 


Trp Gly Gly Arg Ser Pro Gly Gly Val Ser Glu Ser Glu Ala Gly Ser 
465                 470                 475                 480 


Pro Leu Ala Gly Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Val Gly 
                485                 490                 495     


Ser Asp Cys Ser Ser Pro Val Glu Cys Asp Phe Thr Ser Pro Gly Asp 
            500                 505                 510         


Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val Val Ile Pro Pro 
        515                 520                 525             


Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser 
    530                 535             


<210>  6581
<211>  560
<212>  PRT
<213>  Homo sapiens

<400>  6581

Met Ser Cys Arg Cys Ile Phe Leu Met Lys His Gly Glu Arg Val Gly 
1               5                   10                  15      


Trp Pro Val Gly Val Ser Met Pro Arg Gly Trp Ala Ala Pro Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Gln Gly Gly Trp Gly Cys Pro Asp Leu Val Cys Tyr 
        35                  40                  45              


Thr Asp Tyr Leu Gln Thr Val Ile Cys Ile Leu Glu Met Trp Asn Leu 
    50                  55                  60                  


His Pro Ser Thr Leu Thr Leu Thr Trp Gln Asp Gln Tyr Glu Glu Leu 
65                  70                  75                  80  


Lys Asp Glu Ala Thr Ser Cys Ser Leu His Arg Ser Ala His Asn Ala 
                85                  90                  95      


Thr His Ala Thr Tyr Thr Cys His Met Asp Val Phe His Phe Met Ala 
            100                 105                 110         


Asp Asp Ile Phe Ser Val Asn Ile Thr Asp Gln Ser Gly Asn Tyr Ser 
        115                 120                 125             


Gln Glu Cys Gly Ser Phe Leu Leu Ala Glu Ser Ile Lys Pro Ala Pro 
    130                 135                 140                 


Pro Phe Asn Val Thr Val Thr Phe Ser Gly Gln Tyr Asn Ile Ser Trp 
145                 150                 155                 160 


Arg Ser Asp Tyr Glu Asp Pro Ala Phe Tyr Met Leu Lys Gly Lys Leu 
                165                 170                 175     


Gln Tyr Glu Leu Gln Tyr Arg Asn Arg Gly Asp Pro Trp Ala Val Ser 
            180                 185                 190         


Pro Arg Arg Lys Leu Ile Ser Val Asp Ser Arg Ser Val Ser Leu Leu 
        195                 200                 205             


Pro Leu Glu Phe Arg Lys Asp Ser Ser Tyr Glu Leu Gln Val Arg Ala 
    210                 215                 220                 


Gly Pro Met Pro Gly Ser Ser Tyr Gln Gly Thr Trp Ser Glu Trp Ser 
225                 230                 235                 240 


Asp Pro Val Ile Phe Gln Thr Gln Ser Glu Glu Leu Lys Glu Gly Trp 
                245                 250                 255     


Asn Pro His Leu Leu Leu Leu Leu Leu Leu Val Ile Val Phe Ile Pro 
            260                 265                 270         


Ala Phe Trp Ser Leu Lys Thr His Pro Leu Trp Arg Leu Trp Lys Lys 
        275                 280                 285             


Ile Trp Ala Val Pro Ser Pro Glu Arg Phe Phe Met Pro Leu Tyr Lys 
    290                 295                 300                 


Gly Cys Ser Gly Asp Phe Lys Lys Trp Val Gly Ala Pro Phe Thr Gly 
305                 310                 315                 320 


Ser Ser Leu Glu Leu Gly Pro Trp Ser Pro Glu Val Pro Ser Thr Leu 
                325                 330                 335     


Glu Val Tyr Ser Cys His Pro Pro Arg Ser Pro Ala Lys Arg Leu Gln 
            340                 345                 350         


Leu Thr Glu Leu Gln Glu Pro Ala Glu Leu Val Glu Ser Asp Gly Val 
        355                 360                 365             


Pro Lys Pro Ser Phe Trp Pro Thr Ala Gln Asn Ser Gly Gly Ser Ala 
    370                 375                 380                 


Tyr Ser Glu Glu Arg Asp Arg Pro Tyr Gly Leu Val Ser Ile Asp Thr 
385                 390                 395                 400 


Val Thr Val Leu Asp Ala Glu Gly Pro Cys Thr Trp Pro Cys Ser Cys 
                405                 410                 415     


Glu Asp Asp Gly Tyr Pro Ala Leu Asp Leu Asp Ala Gly Leu Glu Pro 
            420                 425                 430         


Ser Pro Gly Leu Glu Asp Pro Leu Leu Asp Ala Gly Thr Thr Val Leu 
        435                 440                 445             


Ser Cys Gly Cys Val Ser Ala Gly Ser Pro Gly Leu Gly Gly Pro Leu 
    450                 455                 460                 


Gly Ser Leu Leu Asp Arg Leu Lys Pro Pro Leu Ala Asp Gly Glu Asp 
465                 470                 475                 480 


Trp Ala Gly Gly Leu Pro Trp Gly Gly Arg Ser Pro Gly Gly Val Ser 
                485                 490                 495     


Glu Ser Glu Ala Gly Ser Pro Leu Ala Gly Leu Asp Met Asp Thr Phe 
            500                 505                 510         


Asp Ser Gly Phe Val Gly Ser Asp Cys Ser Ser Pro Val Glu Cys Asp 
        515                 520                 525             


Phe Thr Ser Pro Gly Asp Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln 
    530                 535                 540                 


Trp Val Val Ile Pro Pro Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser 
545                 550                 555                 560 


<210>  6582
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  6582

Met Asp Pro Glu His Ala Lys Pro Glu Ser Ser Glu Ala Pro Ser Gly 
1               5                   10                  15      


Asn Leu Lys Gln Pro Glu Thr Ala Ala Ala Leu Ala Ser Ser Gly Ser 
            20                  25                  30          


Val Val Ser Ser Val Pro Lys Ala Gln Arg Asn Ile Ser Ala Lys Thr 
        35                  40                  45              


Ala Pro Arg Lys His Pro Ala Val Ser Ile Arg Ser Ala Gln Ser Ala 
    50                  55                  60                  


Ala Ala Ala Arg Pro Gln Gly Ser Glu Gly Thr Ala Pro Ser Arg Lys 
65                  70                  75                  80  


Ala Thr Thr Arg Pro Pro Pro Lys Pro Thr Leu Pro Pro Pro Thr Pro 
                85                  90                  95      


Ser Ala His Thr Glu Ser Lys Leu Leu Asn Glu Met Ala Ile Lys Glu 
            100                 105                 110         


Arg Val Glu Gly Arg Ala Lys Val Pro Tyr Lys Phe Arg Asp Ser Leu 
        115                 120                 125             


Lys Arg Phe Ser Phe Ser Pro Thr Gly Met Leu Lys Ile Leu Arg Leu 
    130                 135                 140                 


Ser Leu Ile Leu Gly Ala Leu Ala Cys Phe Ile Ile Thr Gln Ala Asn 
145                 150                 155                 160 


Glu Ser Phe Ile Thr Ile Thr Ser Leu Glu Ile Cys Ile Val Val Phe 
                165                 170                 175     


Phe Ile Leu Ile Tyr Val Leu Thr Leu His His Leu Leu Thr Tyr Leu 
            180                 185                 190         


His Trp Pro Leu Leu Asp Leu Thr Asn Ser Ile Ile Thr Ala Val Phe 
        195                 200                 205             


Leu Ser Val Val Ala Ile Leu Ala Met Gln Glu Lys Lys Arg Arg His 
    210                 215                 220                 


Leu Leu Tyr Val Gly Gly Arg 
225                 230     


<210>  6583
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  6583

Met Asp Pro Glu His Ala Lys Pro Glu Ser Ser Glu Ala Pro Ser Gly 
1               5                   10                  15      


Asn Leu Lys Gln Pro Glu Thr Ala Ala Ala Leu Ser Leu Ile Leu Gly 
            20                  25                  30          


Ala Leu Ala Cys Phe Ile Ile Thr Gln Ala Asn Glu Ser Phe Ile Thr 
        35                  40                  45              


Ile Thr Ser Leu Glu Ile Cys Ile Val Val Phe Phe Ile Leu Ile Tyr 
    50                  55                  60                  


Val Leu Thr Leu His His Leu Leu Thr Tyr Leu His Trp Pro Leu Leu 
65                  70                  75                  80  


Asp Leu Thr Asn Ser Ile Ile Thr Ala Val Phe Leu Ser Val Val Ala 
                85                  90                  95      


Ile Leu Ala Met Gln Glu Lys Lys Arg Arg His Leu Leu Tyr Val Gly 
            100                 105                 110         


Gly Ser Leu Cys Leu Thr Ala Val Ile Val Cys Cys Ile Asp Ala Phe 
        115                 120                 125             


Val Val Thr Thr Lys Met Arg Thr Asn Leu Lys Arg Phe Leu Gly Val 
    130                 135                 140                 


Glu Val Glu Arg Lys Leu Ser Pro Ala Lys Asp Ala Tyr Pro Glu Thr 
145                 150                 155                 160 


Gly Pro Asp Ala Pro Gln Arg Pro Ala 
                165                 


<210>  6584
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  6584

Met Asp Pro Glu His Ala Lys Pro Glu Ser Ser Glu Ala Pro Ser Gly 
1               5                   10                  15      


Asn Leu Lys Gln Pro Glu Thr Ala Ala Ala Leu Ser Leu Ile Leu Gly 
            20                  25                  30          


Ala Leu Ala Cys Phe Ile Ile Thr Gln Ala Asn Glu Ser Phe Ile Thr 
        35                  40                  45              


Ile Thr Ser Leu Glu Ile Cys Ile Val Val Phe Phe Ile Leu Ile Tyr 
    50                  55                  60                  


Val Leu Thr Leu His His Leu Leu Thr Tyr Leu His Trp Pro Leu Leu 
65                  70                  75                  80  


Asp Leu Thr Asn Ser Ile Ile Thr Ala Val Phe Leu Ser Val Val Ala 
                85                  90                  95      


Ile Leu Ala Met Gln Glu Lys Lys Arg Arg His Leu Leu Tyr Val Gly 
            100                 105                 110         


Gly Arg 
        


<210>  6585
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  6585

Met Asp Pro Glu His Ala Lys Pro Glu Ser Ser Glu Ala Pro Ser Gly 
1               5                   10                  15      


Asn Leu Lys Gln Pro Glu Thr Ala Ala Ala Leu Ala Ser Ser Gly Ser 
            20                  25                  30          


Val Asp Leu Thr Asn Ser Ile Ile Thr Ala Val Phe Leu Ser Val Val 
        35                  40                  45              


Ala Ile Leu Ala Met Gln Glu Lys Lys Arg Arg His Leu Leu Tyr Val 
    50                  55                  60                  


Gly Gly Ser Leu Cys Leu Thr Ala Val Ile Val Cys Cys Ile Asp Ala 
65                  70                  75                  80  


Phe Val Val Thr Thr Lys Met Arg Thr Asn Leu Lys Arg Phe Leu Gly 
                85                  90                  95      


Val Glu Val Glu Arg Lys Leu Ser Pro Ala Lys Asp Ala Tyr Pro Glu 
            100                 105                 110         


Thr Gly Pro Asp Ala Pro Gln Arg Pro Ala 
        115                 120         


<210>  6586
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  6586

Met Asp Pro Glu His Ala Lys Pro Glu Ser Ser Glu Ala Pro Ser Gly 
1               5                   10                  15      


Asn Leu Lys Gln Pro Glu Thr Ala Ala Ala Leu Asp Leu Thr Asn Ser 
            20                  25                  30          


Ile Ile Thr Ala Val Phe Leu Ser Val Val Ala Ile Leu Ala Met Gln 
        35                  40                  45              


Glu Lys Lys Arg Arg His Leu Leu Tyr Val Gly Gly Ser Leu Cys Leu 
    50                  55                  60                  


Thr Ala Val Ile Val Cys Cys Ile Asp Ala Phe Val Val Thr Thr Lys 
65                  70                  75                  80  


Met Arg Thr Asn Leu Lys Arg Phe Leu Gly Val Glu Val Glu Arg Lys 
                85                  90                  95      


Leu Ser Pro Ala Lys Asp Ala Tyr Pro Glu Thr Gly Pro Asp Ala Pro 
            100                 105                 110         


Gln Arg Pro Ala 
        115     


<210>  6587
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  6587

Met Asp Pro Glu His Ala Lys Pro Glu Ser Ser Glu Ala Pro Ser Gly 
1               5                   10                  15      


Asn Leu Lys Gln Pro Glu Thr Ala Ala Ala Leu Asp Leu Thr Asn Ser 
            20                  25                  30          


Ile Ile Thr Ala Val Phe Leu Ser Val Val Ala Ile Leu Ala Met Gln 
        35                  40                  45              


Glu Lys Lys Arg Arg His Leu Leu Tyr Val Gly Gly Arg 
    50                  55                  60      


<210>  6588
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  6588

Met Asp Pro Glu His Ala Lys Pro Glu Ser Ser Glu Ala Pro Ser Gly 
1               5                   10                  15      


Asn Leu Lys Gln Pro Glu Thr Ala Ala Ala Leu Arg 
            20                  25              


<210>  6589
<211>  848
<212>  PRT
<213>  Homo sapiens

<400>  6589

Met Trp Leu Arg Leu Gly Pro Pro Ser Leu Ser Leu Ser Pro Lys Pro 
1               5                   10                  15      


Thr Val Gly Arg Ser Leu Cys Leu Thr Leu Trp Phe Leu Ser Leu Ala 
            20                  25                  30          


Leu Arg Ala Ser Thr Gln Ala Pro Ala Pro Thr Val Asn Thr His Phe 
        35                  40                  45              


Gly Lys Leu Arg Gly Ala Arg Val Pro Leu Pro Ser Glu Ile Leu Gly 
    50                  55                  60                  


Pro Val Asp Gln Tyr Leu Gly Val Pro Tyr Ala Ala Pro Pro Ile Gly 
65                  70                  75                  80  


Glu Lys Arg Phe Leu Pro Pro Glu Pro Pro Pro Ser Trp Ser Gly Ile 
                85                  90                  95      


Arg Asn Ala Thr His Phe Pro Pro Val Cys Pro Gln Asn Ile His Thr 
            100                 105                 110         


Ala Val Pro Glu Val Met Leu Pro Val Trp Phe Thr Ala Asn Leu Asp 
        115                 120                 125             


Ile Val Ala Thr Tyr Ile Gln Glu Pro Asn Glu Asp Cys Leu Tyr Leu 
    130                 135                 140                 


Asn Val Tyr Val Pro Thr Glu Asp Val Lys Arg Ile Ser Lys Glu Cys 
145                 150                 155                 160 


Ala Arg Lys Pro Asn Lys Lys Ile Cys Arg Lys Gly Gly Ser Gly Ala 
                165                 170                 175     


Lys Lys Gln Gly Glu Asp Leu Ala Asp Asn Asp Gly Asp Glu Asp Glu 
            180                 185                 190         


Asp Ile Arg Asp Ser Gly Ala Lys Pro Val Met Val Tyr Ile His Gly 
        195                 200                 205             


Gly Ser Tyr Met Glu Gly Thr Gly Asn Met Ile Asp Gly Ser Ile Leu 
    210                 215                 220                 


Ala Ser Tyr Gly Asn Val Ile Val Ile Thr Leu Asn Tyr Arg Val Gly 
225                 230                 235                 240 


Val Leu Gly Phe Leu Ser Thr Gly Asp Gln Ala Ala Lys Gly Asn Tyr 
                245                 250                 255     


Gly Leu Leu Asp Gln Ile Gln Ala Leu Arg Trp Val Ser Glu Asn Ile 
            260                 265                 270         


Ala Phe Phe Gly Gly Asp Pro Arg Arg Ile Thr Val Phe Gly Ser Gly 
        275                 280                 285             


Ile Gly Ala Ser Cys Val Ser Leu Leu Thr Leu Ser His His Ser Glu 
    290                 295                 300                 


Gly Leu Phe Gln Arg Ala Ile Ile Gln Ser Gly Ser Ala Leu Ser Ser 
305                 310                 315                 320 


Trp Ala Val Asn Tyr Gln Pro Val Lys Tyr Thr Ser Leu Leu Ala Asp 
                325                 330                 335     


Lys Val Gly Cys Asn Val Leu Asp Thr Val Asp Met Val Asp Cys Leu 
            340                 345                 350         


Arg Gln Lys Ser Ala Lys Glu Leu Val Glu Gln Asp Ile Gln Pro Ala 
        355                 360                 365             


Arg Tyr His Val Ala Phe Gly Pro Val Ile Asp Gly Asp Val Ile Pro 
    370                 375                 380                 


Asp Asp Pro Glu Ile Leu Met Glu Gln Gly Glu Phe Leu Asn Tyr Asp 
385                 390                 395                 400 


Ile Met Leu Gly Val Asn Gln Gly Glu Gly Leu Lys Phe Val Glu Gly 
                405                 410                 415     


Val Val Asp Pro Glu Asp Gly Val Ser Gly Thr Asp Phe Asp Tyr Ser 
            420                 425                 430         


Val Ser Asn Phe Val Asp Asn Leu Tyr Gly Tyr Pro Glu Gly Lys Asp 
        435                 440                 445             


Thr Leu Arg Glu Thr Ile Lys Phe Met Tyr Thr Asp Trp Ala Asp Arg 
    450                 455                 460                 


Asp Asn Pro Glu Thr Arg Arg Lys Thr Leu Val Ala Leu Phe Thr Asp 
465                 470                 475                 480 


His Gln Trp Val Glu Pro Ser Val Val Thr Ala Asp Leu His Ala Arg 
                485                 490                 495     


Tyr Gly Ser Pro Thr Tyr Phe Tyr Ala Phe Tyr His His Cys Gln Ser 
            500                 505                 510         


Leu Met Lys Pro Ala Trp Ser Asp Ala Ala His Gly Asp Glu Val Pro 
        515                 520                 525             


Tyr Val Phe Gly Val Pro Met Val Gly Pro Thr Asp Leu Phe Pro Cys 
    530                 535                 540                 


Asn Phe Ser Lys Asn Asp Val Met Leu Ser Ala Val Val Met Thr Tyr 
545                 550                 555                 560 


Trp Thr Asn Phe Ala Lys Thr Gly Asp Pro Asn Lys Pro Val Pro Gln 
                565                 570                 575     


Asp Thr Lys Phe Ile His Thr Lys Ala Asn Arg Phe Glu Glu Val Ala 
            580                 585                 590         


Trp Ser Lys Tyr Asn Pro Arg Asp Gln Leu Tyr Leu His Ile Gly Leu 
        595                 600                 605             


Lys Pro Arg Val Arg Asp His Tyr Arg Ala Thr Lys Val Ala Phe Trp 
    610                 615                 620                 


Lys His Leu Val Pro His Leu Tyr Asn Leu His Asp Met Phe His Tyr 
625                 630                 635                 640 


Thr Ser Thr Thr Thr Lys Val Pro Pro Pro Asp Thr Thr His Ser Ser 
                645                 650                 655     


His Ile Thr Arg Arg Pro Asn Gly Lys Thr Trp Ser Thr Lys Arg Pro 
            660                 665                 670         


Ala Ile Ser Pro Ala Tyr Ser Asn Glu Asn Ala Gln Gly Ser Trp Asn 
        675                 680                 685             


Gly Asp Gln Asp Ala Gly Pro Leu Leu Val Glu Asn Pro Arg Asp Tyr 
    690                 695                 700                 


Ser Thr Glu Leu Ser Val Thr Ile Ala Val Gly Ala Ser Leu Leu Phe 
705                 710                 715                 720 


Leu Asn Val Leu Ala Phe Ala Ala Leu Tyr Tyr Arg Lys Asp Lys Arg 
                725                 730                 735     


Arg Gln Glu Pro Leu Arg Gln Pro Ser Pro Gln Arg Gly Ala Gly Ala 
            740                 745                 750         


Pro Glu Leu Gly Ala Ala Pro Glu Glu Glu Leu Ala Ala Leu Gln Leu 
        755                 760                 765             


Gly Pro Thr His His Glu Cys Glu Ala Gly Pro Pro His Asp Thr Leu 
    770                 775                 780                 


Arg Leu Thr Ala Leu Pro Asp Tyr Thr Leu Thr Leu Arg Arg Ser Pro 
785                 790                 795                 800 


Asp Asp Ile Pro Leu Met Thr Pro Asn Thr Ile Thr Met Ile Pro Asn 
                805                 810                 815     


Ser Leu Val Gly Leu Gln Thr Leu His Pro Tyr Asn Thr Phe Ala Ala 
            820                 825                 830         


Gly Phe Asn Ser Thr Gly Leu Pro His Ser His Ser Thr Thr Arg Val 
        835                 840                 845             


<210>  6590
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  6590

Met Pro Leu His Val Lys Trp Pro Phe Pro Ala Val Pro Pro Leu Thr 
1               5                   10                  15      


Trp Thr Leu Ala Ser Ser Val Val Met Gly Leu Val Gly Thr Tyr Ser 
            20                  25                  30          


Cys Phe Trp Thr Lys Tyr Met Asn His Leu Thr Val His Asn Arg Glu 
        35                  40                  45              


Val Leu Tyr Glu Leu Ile Glu Lys Arg Gly Pro Ala Thr Pro Leu Ile 
    50                  55                  60                  


Thr Val Ser Asn His Gln Ser Cys Met Asp Asp Pro His Leu Trp Gly 
65                  70                  75                  80  


Ile Leu Lys Leu Arg His Ile Trp Asn Leu Lys Leu Met Arg Trp Thr 
                85                  90                  95      


Pro Ala Ala Ala Asp Ile Cys Phe Thr Lys Glu Leu His Ser His Phe 
            100                 105                 110         


Phe Ser Leu Gly Lys Cys Val Pro Val Cys Arg Gly Asp Gly Val Tyr 
        115                 120                 125             


Gln Lys Gly Met Asp Phe Ile Leu Glu Lys Leu Asn His Gly Asp Trp 
    130                 135                 140                 


Val His Ile Phe Pro Glu Gly Lys Val Asn Met Ser Ser Glu Phe Leu 
145                 150                 155                 160 


Arg Phe Lys Trp Gly Ile Gly Arg Leu Ile Ala Glu Cys His Leu Asn 
                165                 170                 175     


Pro Ile Ile Leu Pro Leu Trp His Val Gly Met Asn Asp Val Leu Pro 
            180                 185                 190         


Asn Ser Pro Pro Tyr Phe Pro Arg Phe Gly Gln Lys Ile Thr Val Leu 
        195                 200                 205             


Ile Gly Lys Pro Phe Ser Ala Leu Pro Val Leu Glu Arg Leu Arg Ala 
    210                 215                 220                 


Glu Asn Lys Ser Ala Val Glu Met Arg Lys Ala Leu Thr Asp Phe Ile 
225                 230                 235                 240 


Gln Glu Glu Phe Gln His Leu Lys Thr Gln Ala Glu Gln Leu His Asn 
                245                 250                 255     


His Leu Gln Pro Gly Arg 
            260         


<210>  6591
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  6591

Met Pro Leu His Val Lys Trp Pro Phe Pro Ala Val Pro Pro Leu Thr 
1               5                   10                  15      


Trp Thr Leu Ala Ser Ser Val Val Met Gly Leu Val Gly Thr Tyr Ser 
            20                  25                  30          


Cys Phe Trp Thr Lys Tyr Met Asn His Leu Thr Val His Asn Arg Glu 
        35                  40                  45              


Val Leu Tyr Glu Leu Ile Glu Lys Arg Gly Pro Ala Thr Pro Leu Ile 
    50                  55                  60                  


Thr Val Ser Asn His Gln Ser Cys Met Asp Asp Pro His Leu Trp Gly 
65                  70                  75                  80  


Ile Leu Lys Leu Arg His Ile Trp Asn Leu Lys Leu Met Arg Trp Thr 
                85                  90                  95      


Pro Ala Ala Ala Asp Ile Cys Phe Thr Lys Glu Leu His Ser His Phe 
            100                 105                 110         


Phe Ser Leu Gly Lys Cys Val Pro Val Cys Arg Gly Ala Glu Phe Phe 
        115                 120                 125             


Gln Ala Glu Asn Glu Gly Lys Gly Val Leu Asp Thr Gly Arg His Met 
    130                 135                 140                 


Pro Gly Ala Gly Lys Arg Arg Glu Lys Gly Asp Gly Val Tyr Gln Lys 
145                 150                 155                 160 


Gly Met Asp Phe Ile Leu Glu Lys Leu Asn His Gly Asp Trp Val His 
                165                 170                 175     


Ile Phe Pro Glu Gly Ile Gly Arg Leu Ile Ala Glu Cys His Leu Asn 
            180                 185                 190         


Pro Ile Ile Leu Pro Leu Trp His Val Gly Met Asn Asp Val Leu Pro 
        195                 200                 205             


Asn Ser Pro Pro Tyr Phe Pro Arg Phe Gly Gln Lys Ile Thr Val Leu 
    210                 215                 220                 


Ile Gly Lys Pro Phe Ser Ala Leu Pro Val Leu Glu Arg Leu Arg Ala 
225                 230                 235                 240 


Glu Asn Lys Ser Ala Val Glu Met Arg Lys Ala Leu Thr Asp Phe Ile 
                245                 250                 255     


Gln Glu Glu Phe Gln His Leu Lys Thr Gln Ala Glu Gln Leu His Asn 
            260                 265                 270         


His Leu Gln Pro Gly Arg 
        275             


<210>  6592
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  6592

Met Pro Leu His Val Lys Trp Pro Phe Pro Ala Val Pro Pro Leu Thr 
1               5                   10                  15      


Trp Thr Leu Ala Ser Ser Val Val Met Gly Leu Val Gly Thr Tyr Ser 
            20                  25                  30          


Cys Phe Trp Thr Lys Tyr Met Asn His Leu Thr Val His Asn Arg Glu 
        35                  40                  45              


Val Leu Tyr Glu Leu Ile Glu Lys Arg Gly Pro Ala Thr Pro Leu Ile 
    50                  55                  60                  


Thr Val Ser Asn His Gln Ser Cys Met Asp Asp Pro His Leu Trp Gly 
65                  70                  75                  80  


Ile Leu Lys Leu Arg His Ile Trp Asn Leu Lys Leu Met Arg Trp Thr 
                85                  90                  95      


Pro Ala Ala Ala Asp Ile Cys Phe Thr Lys Glu Leu His Ser His Phe 
            100                 105                 110         


Phe Ser Leu Gly Lys Cys Val Pro Val Cys Arg Gly Asp Gly Val Tyr 
        115                 120                 125             


Gln Lys Gly Met Asp Phe Ile Leu Glu Lys Leu Asn His Gly Asp Trp 
    130                 135                 140                 


Val His Ile Phe Pro Glu Gly Ile Gly Arg Leu Ile Ala Glu Cys His 
145                 150                 155                 160 


Leu Asn Pro Ile Ile Leu Pro Leu Trp His Val Gly Met Asn Asp Val 
                165                 170                 175     


Leu Pro Asn Ser Pro Pro Tyr Phe Pro Arg Phe Gly Gln Lys Ile Thr 
            180                 185                 190         


Val Leu Ile Gly Lys Pro Phe Ser Ala Leu Pro Val Leu Glu Arg Leu 
        195                 200                 205             


Arg Ala Glu Asn Lys Ser Ala Val Glu Met Arg Lys Ala Leu Thr Asp 
    210                 215                 220                 


Phe Ile Gln Glu Glu Phe Gln His Leu Lys Thr Gln Ala Glu Gln Leu 
225                 230                 235                 240 


His Asn His Leu Gln Pro Gly Arg 
                245             


<210>  6593
<211>  503
<212>  PRT
<213>  Homo sapiens

<400>  6593

Met Ala Gly Leu Ser Asp Leu Glu Leu Arg Arg Glu Leu Gln Ala Leu 
1               5                   10                  15      


Gly Phe Gln Pro Gly Pro Ile Thr Asp Thr Thr Arg Asp Val Tyr Arg 
            20                  25                  30          


Asn Lys Leu Arg Arg Leu Arg Gly Glu Ala Arg Leu Arg Asp Glu Glu 
        35                  40                  45              


Arg Leu Arg Glu Glu Ala Arg Pro Arg Gly Glu Glu Arg Leu Arg Glu 
    50                  55                  60                  


Glu Ala Arg Leu Arg Glu Asp Ala Pro Leu Arg Ala Arg Pro Ala Ala 
65                  70                  75                  80  


Ala Ser Pro Arg Ala Glu Pro Trp Leu Ser Gln Pro Ala Ser Gly Ser 
                85                  90                  95      


Ala Tyr Ala Thr Pro Gly Ala Tyr Gly Asp Ile Arg Pro Ser Ala Ala 
            100                 105                 110         


Ser Trp Val Gly Ser Arg Gly Leu Ala Tyr Pro Ala Arg Pro Ala Gln 
        115                 120                 125             


Leu Arg Arg Arg Ala Ser Val Arg Gly Ser Ser Glu Glu Asp Glu Asp 
    130                 135                 140                 


Ala Arg Thr Pro Asp Arg Ala Thr Gln Gly Pro Gly Leu Ala Ala Arg 
145                 150                 155                 160 


Arg Trp Trp Ala Ala Ser Pro Ala Pro Ala Arg Leu Pro Ser Ser Leu 
                165                 170                 175     


Leu Gly Pro Asp Pro Arg Pro Gly Leu Arg Ala Thr Arg Ala Gly Pro 
            180                 185                 190         


Ala Gly Ala Ala Arg Ala Arg Pro Glu Val Gly Arg Arg Leu Glu Arg 
        195                 200                 205             


Trp Leu Ser Arg Leu Leu Leu Trp Ala Ser Leu Gly Leu Leu Leu Val 
    210                 215                 220                 


Phe Leu Gly Ile Leu Trp Val Lys Met Gly Lys Pro Ser Ala Pro Gln 
225                 230                 235                 240 


Glu Ala Glu Asp Asn Met Lys Leu Leu Pro Val Asp Cys Glu Arg Lys 
                245                 250                 255     


Thr Asp Glu Phe Cys Gln Ala Lys Gln Lys Ala Ala Leu Leu Glu Leu 
            260                 265                 270         


Leu His Glu Leu Tyr Asn Phe Leu Ala Ile Gln Ala Gly Asn Phe Glu 
        275                 280                 285             


Cys Gly Asn Pro Glu Asn Leu Lys Ser Lys Cys Ile Pro Val Met Glu 
    290                 295                 300                 


Ala Gln Glu Tyr Ile Ala Asn Val Thr Ser Ser Ser Ser Ala Lys Phe 
305                 310                 315                 320 


Glu Ala Ala Leu Thr Trp Ile Leu Ser Ser Asn Lys Asp Val Gly Ile 
                325                 330                 335     


Trp Leu Lys Gly Glu Asp Gln Ser Glu Leu Val Thr Thr Val Asp Lys 
            340                 345                 350         


Val Val Cys Leu Glu Ser Ala His Pro Arg Met Gly Val Gly Cys Arg 
        355                 360                 365             


Leu Ser Arg Ala Leu Leu Thr Ala Val Thr Asn Val Leu Ile Phe Phe 
    370                 375                 380                 


Trp Cys Leu Ala Phe Leu Trp Gly Leu Leu Ile Leu Leu Lys Tyr Arg 
385                 390                 395                 400 


Trp Arg Lys Leu Glu Glu Glu Glu Gln Ala Met Tyr Glu Met Val Lys 
                405                 410                 415     


Lys Ile Ile Asp Val Val Gln Asp His Tyr Val Asp Trp Glu Gln Asp 
            420                 425                 430         


Met Glu Arg Tyr Pro Tyr Val Gly Ile Leu His Val Arg Asp Ser Leu 
        435                 440                 445             


Ile Pro Pro Gln Ser Arg Arg Arg Met Lys Arg Val Trp Asp Arg Ala 
    450                 455                 460                 


Val Glu Phe Leu Ala Ser Asn Glu Ser Arg Ile Gln Thr Glu Ser His 
465                 470                 475                 480 


Arg Val Ala Gly Glu Asp Met Leu Val Trp Arg Trp Thr Lys Pro Ser 
                485                 490                 495     


Ser Phe Ser Asp Ser Glu Arg 
            500             


<210>  6594
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  6594

Met Pro Lys Thr Met His Phe Leu Phe Arg Phe Ile Val Phe Phe Tyr 
1               5                   10                  15      


Leu Trp Gly Leu Phe Thr Ala Gln Arg Gln Lys Lys Glu Glu Ser Thr 
            20                  25                  30          


Glu Glu Val Lys Ile Glu Val Leu His Arg Pro Glu Asn Cys Ser Lys 
        35                  40                  45              


Thr Ser Lys Lys Gly Asp Leu Leu Asn Ala His Tyr Asp Gly Tyr Leu 
    50                  55                  60                  


Ala Lys Asp Gly Ser Lys Phe Tyr Cys Ser Arg Thr Gln Asn Glu Gly 
65                  70                  75                  80  


His Pro Lys Trp Phe Val Leu Gly Val Gly Gln Val Ile Lys Gly Leu 
                85                  90                  95      


Asp Ile Ala Met Thr Asp Met Cys Pro Gly Glu Lys Arg Lys Val Val 
            100                 105                 110         


Ile Pro Pro Ser Phe Ala Tyr Gly Lys Glu Gly Tyr Ala Glu Gly Lys 
        115                 120                 125             


Ile Pro Pro Asp Ala Thr Leu Ile Phe Glu Ile Glu Leu Tyr Ala Val 
    130                 135                 140                 


Thr Lys Gly Pro Arg Ser Ile Glu Thr Phe Lys Gln Ile Asp Met Asp 
145                 150                 155                 160 


Asn Asp Arg Gln Leu Ser Lys Ala Glu Ile Asn Leu Tyr Leu Gln Arg 
                165                 170                 175     


Glu Phe Glu Lys Asp Glu Lys Pro Arg Asp Lys Ser Tyr Gln Asp Ala 
            180                 185                 190         


Val Leu Glu Asp Ile Phe Lys Lys Asn Asp His Asp Gly Asp Gly Phe 
        195                 200                 205             


Ile Ser Pro Lys Glu Tyr Asn Val Tyr Gln His Asp Glu Leu 
    210                 215                 220         


<210>  6595
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  6595

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Ala Ser Trp Thr Arg Pro Glu Lys Gln Glu Thr Leu Asp Gly His 
        355                 360                 365             


Met Val Val Arg Ser His Ala Arg Val Ser Ser Leu Thr Leu Lys Ser 
    370                 375                 380                 


Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile Cys Thr Ala Ser Asn Thr 
385                 390                 395                 400 


Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu Glu Val Gln Tyr Ala Pro 
                405                 410                 415     


Lys Leu Gln Gly Pro Val Ala Val Tyr Thr Trp Glu Gly Asn Gln Val 
            420                 425                 430         


Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro Ser Ala Thr Ile Ser Trp 
        435                 440                 445             


Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser Asn Tyr Ser Asn Ile Lys 
    450                 455                 460                 


Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu Glu Val Thr Pro Asp Ser 
465                 470                 475                 480 


Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr Ala Val Asn Arg Ile Gly 
                485                 490                 495     


Gln Glu Ser Leu Glu Phe Ile Leu Val Gln Ala Asp Thr Pro Ser Ser 
            500                 505                 510         


Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser Ser Thr Ala Gln Val Gln 
        515                 520                 525             


Phe Asp Glu Pro Glu Ala Thr Gly Gly Val Pro Ile Leu Lys Tyr Lys 
    530                 535                 540                 


Ala Glu Trp Arg Ala Val Gly Glu Glu Val Trp His Ser Lys Trp Tyr 
545                 550                 555                 560 


Asp Ala Lys Glu Ala Ser Met Glu Gly Ile Val Thr Ile Val Gly Leu 
                565                 570                 575     


Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu Ala Ala Leu Asn Gly Lys 
            580                 585                 590         


Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu Phe Lys Thr Gln Pro Val 
        595                 600                 605             


Gln Gly Glu Pro Ser Ala Pro Lys Leu Glu Gly Gln Met Gly Glu Asp 
    610                 615                 620                 


Gly Asn Ser Ile Lys Val Asn Leu Ile Lys Gln Asp Asp Gly Gly Ser 
625                 630                 635                 640 


Pro Ile Arg His Tyr Leu Val Arg Tyr Arg Ala Leu Ser Ser Glu Trp 
                645                 650                 655     


Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser Asp His Val Met Leu Lys 
            660                 665                 670         


Ser Leu Asp Trp Asn Ala Glu Tyr Glu Val Tyr Val Val Ala Glu Asn 
        675                 680                 685             


Gln Gln Gly Lys Ser Lys Ala Ala His Phe Val Phe Arg Thr Ser Ala 
    690                 695                 700                 


Gln Pro Thr Ala Ile Pro Ala Asn Gly Ser Pro Thr Ser Gly Leu Ser 
705                 710                 715                 720 


Thr Gly Ala Ile Val Gly Ile Leu Ile Val Ile Phe Val Leu Leu Leu 
                725                 730                 735     


Val Val Val Asp Ile Thr Cys Tyr Phe Leu Asn Lys Cys Gly Leu Phe 
            740                 745                 750         


Met Cys Ile Ala Val Asn Leu Cys Gly Lys Ala Gly Pro Gly Ala Lys 
        755                 760                 765             


Gly Lys Asp Met Glu Glu Gly Lys Ala Ala Phe Ser Lys Asp Glu Ser 
    770                 775                 780                 


Lys Glu Pro Ile Val Glu Val Arg Thr Glu Glu Glu Arg Thr Pro Asn 
785                 790                 795                 800 


His Asp Gly Gly Lys His Thr Glu Pro Asn Glu Thr Thr Pro Leu Thr 
                805                 810                 815     


Glu Pro Glu Lys Gly Pro Val Glu Ala Lys Pro Glu Cys Gln Glu Thr 
            820                 825                 830         


Glu Thr Lys Pro Ala Pro Ala Glu Val Lys Thr Val Pro Asn Asp Ala 
        835                 840                 845             


Thr Gln Thr Lys Glu Asn Glu Ser Lys Ala 
    850                 855             


<210>  6596
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  6596

Met Leu Ala Val Gly Cys Ala Leu Leu Ala Ala Leu Leu Ala Ala Pro 
1               5                   10                  15      


Gly Ala Ala Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg 
            20                  25                  30          


Gly Val Leu Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro 
        35                  40                  45              


Gly Val Glu Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys 
    50                  55                  60                  


Pro Ala Ala Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg 
65                  70                  75                  80  


Leu Leu Leu Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys 
                85                  90                  95      


Tyr Arg Ala Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val 
            100                 105                 110         


Pro Pro Glu Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser 
        115                 120                 125             


Asn Val Val Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr 
    130                 135                 140                 


Lys Ala Val Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp 
145                 150                 155                 160 


Phe Gln Glu Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys 
                165                 170                 175     


Gln Leu Ala Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met 
            180                 185                 190         


Cys Val Ala Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe 
        195                 200                 205             


Gln Gly Cys Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val 
    210                 215                 220                 


Thr Ala Val Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp 
225                 230                 235                 240 


Pro His Ser Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg 
                245                 250                 255     


Tyr Arg Ala Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp 
            260                 265                 270         


Leu Gln His His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His 
        275                 280                 285             


Val Val Gln Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser 
    290                 295                 300                 


Glu Trp Ser Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser 
305                 310                 315                 320 


Pro Pro Ala Glu Asn Glu Val Ser Thr Pro Met Gln Ala Leu Thr Thr 
                325                 330                 335     


Asn Lys Asp Asp Asp Asn Ile Leu Phe Arg Asp Ser Ala Asn Ala Thr 
            340                 345                 350         


Ser Leu Pro Gly Ser Arg Arg Arg Gly Ser Cys Gly Leu 
        355                 360                 365 


<210>  6597
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  6597

Met Phe Ile Trp Thr Ser Gly Arg Thr Ser Ser Ser Tyr Arg His Asp 
1               5                   10                  15      


Glu Lys Arg Asn Ile Tyr Gln Lys Ile Arg Asp His Asp Leu Leu Asp 
            20                  25                  30          


Lys Arg Lys Thr Val Thr Ala Leu Lys Ala Gly Glu Asp Arg Ala Ile 
        35                  40                  45              


Leu Leu Gly Leu Ala Met Met Val Cys Ser Ile Met Met Tyr Phe Leu 
    50                  55                  60                  


Leu Gly Ile Thr Leu Leu Arg Ser Tyr Met Gln Ser Val Trp Thr Glu 
65                  70                  75                  80  


Glu Ser Gln Cys Thr Leu Leu Asn Ala Ser Ile Thr Glu Thr Phe Asn 
                85                  90                  95      


Cys Ser Phe Ser Cys Gly Pro Asp Cys Trp Lys Leu Ser Gln Tyr Pro 
            100                 105                 110         


Cys Leu Gln Val Tyr Val Asn Leu Thr Ser Ser Gly Glu Lys Leu Leu 
        115                 120                 125             


Leu Tyr His Thr Glu Glu Thr Ile Lys Ile Asn Gln Lys Cys Ser Tyr 
    130                 135                 140                 


Ile Pro Lys Cys Gly Lys Asn Phe Glu Glu Ser Met Ser Leu Val Asn 
145                 150                 155                 160 


Val Val Met Glu Asn Phe Arg Lys Tyr Gln His Phe Ser Cys Tyr Ser 
                165                 170                 175     


Asp Pro Glu Gly Asn Gln Lys Ser Val Ile Leu Thr Lys Leu Tyr Ser 
            180                 185                 190         


Ser Asn Val Leu Phe His Ser Leu Phe Trp Pro Thr Cys Met Met Ala 
        195                 200                 205             


Gly Gly Val Ala Ile Val Ala Met Val Lys Leu Thr Gln Tyr Leu Ser 
    210                 215                 220                 


Leu Leu Cys Glu Arg Ile Gln Arg Ile Asn Arg 
225                 230                 235 


<210>  6598
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  6598

Met Ala Leu Leu Leu Val Ser Leu Leu Ala Phe Leu Ser Leu Gly Ser 
1               5                   10                  15      


Gly Cys His His Arg Ile Cys His Cys Ser Asn Arg Val Phe Leu Cys 
            20                  25                  30          


Gln Glu Ser Lys Val Thr Glu Ile Pro Ser Asp Leu Pro Arg Asn Ala 
        35                  40                  45              


Ile Glu Leu Arg Phe Val Leu Thr Lys Leu Arg Val Ile Gln Lys Gly 
    50                  55                  60                  


Ala Phe Ser Gly Phe Gly Asp Leu Glu Lys Ile Glu Ile Ser Gln Asn 
65                  70                  75                  80  


Asp Val Leu Glu Val Ile Glu Ala Asp Val Phe Ser Asn Leu Pro Lys 
                85                  90                  95      


Leu His Glu Ile Arg Ile Glu Lys Ala Asn Asn Leu Leu Tyr Ile Asn 
            100                 105                 110         


Pro Glu Ala Phe Gln Asn Leu Pro Asn Leu Gln Tyr Leu Leu Ile Ser 
        115                 120                 125             


Asn Thr Gly Ile Lys His Leu Pro Asp Val His Lys Ile His Ser Leu 
    130                 135                 140                 


Gln Lys Val Leu Leu Trp Leu Asn Lys Asn Gly Ile Gln Glu Ile His 
145                 150                 155                 160 


Asn Cys Ala Phe Asn Gly Thr Gln Leu Asp Glu Leu Asn Leu Ser Asp 
                165                 170                 175     


Asn Asn Asn Leu Glu Glu Leu Pro Asn Asp Val Phe His Gly Ala Ser 
            180                 185                 190         


Gly Pro Val Ile Leu Asp Ile Ser Arg Thr Arg Ile His Ser Leu Pro 
        195                 200                 205             


Ser Tyr Gly Leu Glu Asn Leu Lys Lys Leu Arg Ala Arg Ser Thr Tyr 
    210                 215                 220                 


Asn Leu Lys Lys Leu Pro Thr Leu Glu Lys Leu Val Ala Leu Met Glu 
225                 230                 235                 240 


Ala Ser Leu Thr Tyr Pro Ser His Cys Cys Ala Phe Ala Asn Trp Arg 
                245                 250                 255     


Arg Gln Ile Ser Glu Leu His Pro Ile Cys Asn Lys Ser Ile Leu Arg 
            260                 265                 270         


Gln Glu Val Asp Tyr Met Thr Gln Ala Arg Gly Gln Arg Ser Ser Leu 
        275                 280                 285             


Ala Glu Asp Asn Glu Ser Ser Tyr Ser Arg Gly Phe Asp Met Thr Tyr 
    290                 295                 300                 


Thr Glu Phe Asp Tyr Asp Leu Cys Asn Glu Val Val Asp Val Thr Cys 
305                 310                 315                 320 


Ser Pro Lys Pro Asp Ala Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr 
                325                 330                 335     


Asn Ile Leu Arg Val Leu Ile Trp Phe Ile Ser Ile Leu Ala Ile Thr 
            340                 345                 350         


Gly Asn Ile Ile Val Leu Val Ile Leu Thr Thr Ser Gln Tyr Lys Leu 
        355                 360                 365             


Thr Val Pro Arg Phe Leu Met Cys Asn Leu Ala Phe Ala Asp Leu Cys 
    370                 375                 380                 


Ile Gly Ile Tyr Leu Leu Leu Ile Ala Ser Val Asp Ile His Thr Lys 
385                 390                 395                 400 


Ser Gln Tyr His Asn Tyr Ala Ile Asp Trp Gln Thr Gly Ala Gly Cys 
                405                 410                 415     


Asp Ala Ala Gly Phe Phe Thr Val Phe Ala Ser Glu Leu Ser Val Tyr 
            420                 425                 430         


Thr Leu Thr Ala Ile Thr Leu Glu Arg Trp His Thr Ile Thr His Ala 
        435                 440                 445             


Met Gln Leu Asp Cys Lys Val Gln Leu Arg His Ala Ala Ser Val Met 
    450                 455                 460                 


Val Met Gly Trp Ile Phe Ala Phe Ala Ala Ala Leu Phe Pro Ile Phe 
465                 470                 475                 480 


Gly Ile Ser Ser Tyr Met Lys Val Ser Ile Cys Leu Pro Met Asp Ile 
                485                 490                 495     


Asp Ser Pro Leu Ser Gln Leu Tyr Val Met Ser Leu Leu Val Leu Asn 
            500                 505                 510         


Val Leu Ala Phe Val Val Ile Cys Gly Cys Tyr Ile His Ile Tyr Leu 
        515                 520                 525             


Thr Val Arg Asn Pro Asn Ile Val Ser Ser Ser Ser Asp Thr Arg Ile 
    530                 535                 540                 


Ala Lys Arg Met Ala Met Leu Ile Phe Thr Asp Phe Leu Cys Met Ala 
545                 550                 555                 560 


Pro Ile Ser Phe Phe Ala Ile Ser Ala Ser Leu Lys Val Pro Leu Ile 
                565                 570                 575     


Thr Val Ser Lys Ala Lys Ile Leu Leu Val Leu Phe His Pro Ile Asn 
            580                 585                 590         


Ser Cys Ala Asn Pro Phe Leu Tyr Ala Ile Phe Thr Lys Asn Phe Arg 
        595                 600                 605             


Arg Asp Phe Phe Ile Leu Leu Ser Lys Cys Gly Cys Tyr Glu Met Gln 
    610                 615                 620                 


Ala Gln Ile Tyr Arg Thr Glu Thr Ser Ser Thr Val His Asn Thr His 
625                 630                 635                 640 


Pro Arg Asn Gly His Cys Ser Ser Ala Pro Arg Val Thr Ser Gly Ser 
                645                 650                 655     


Thr Tyr Ile Leu Val Pro Leu Ser His Leu Ala Gln Asn 
            660                 665                 


<210>  6599
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  6599

Met Ser His Gly Ala Gly Leu Val Arg Thr Thr Cys Ser Ser Gly Ser 
1               5                   10                  15      


Ala Leu Gly Pro Gly Ala Gly Ala Ala Gln Pro Ser Ala Ser Pro Leu 
            20                  25                  30          


Glu Gly Leu Leu Asp Leu Ser Tyr Pro Arg Thr His Ala Ala Leu Leu 
        35                  40                  45              


Lys Val Ala Gln Met Val Thr Leu Leu Ile Ala Phe Ile Cys Val Arg 
    50                  55                  60                  


Ser Ser Leu Trp Thr Asn Tyr Ser Ala Tyr Ser Tyr Phe Glu Val Val 
65                  70                  75                  80  


Thr Ile Cys Asp Leu Ile Met Ile Leu Ala Phe Tyr Leu Val His Leu 
                85                  90                  95      


Phe Arg Phe Tyr Arg Val Leu Thr Cys Ile Ser Trp Pro Leu Ser Ile 
            100                 105                 110         


Phe Gly Phe Met Ala Thr Phe Leu Cys Met Ala Ser Ile Trp Leu Ser 
        115                 120                 125             


Tyr Lys Ile Ser Cys Val Thr Gln Ser Thr Asp Ala Ala Val 
    130                 135                 140         


<210>  6600
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  6600

Met Pro Glu Ala Gly Phe Gln Ala Thr Asn Ala Phe Thr Glu Cys Lys 
1               5                   10                  15      


Phe Thr Cys Thr Ser Gly Lys Cys Leu Tyr Leu Gly Ser Leu Val Cys 
            20                  25                  30          


Asn Gln Gln Asn Asp Cys Gly Asp Asn Ser Asp Glu Glu Asn Cys Leu 
        35                  40                  45              


Leu Val Thr Glu His Pro Pro Pro Gly Ile Phe Asn Ser Glu Leu Glu 
    50                  55                  60                  


Phe Ala Gln Ile Ile Ile Ile Val Val Val Val Thr Val Met Val Val 
65                  70                  75                  80  


Val Ile Val Cys Leu Leu Asn His Tyr Lys Val Ser Thr Arg Ser Phe 
                85                  90                  95      


Ile Asn Arg Pro Asn Gln Ser Arg Arg Arg Glu Asp Gly Leu Pro Gln 
            100                 105                 110         


Glu Gly Cys Leu Trp Pro Ser Asp Ser Ala Ala Pro Arg Leu Gly Ala 
        115                 120                 125             


Ser Glu Ile Met His Ala Pro Arg Ser Arg Asp Arg Phe Thr Ala Pro 
    130                 135                 140                 


Ser Phe Ile Gln Arg Asp Arg Phe Ser Arg Phe Gln Pro Thr Tyr Pro 
145                 150                 155                 160 


Tyr Val Gln His Glu Ile Asp Leu Pro Pro Thr Ile Ser Leu Ser Asp 
                165                 170                 175     


Gly Glu Glu Pro Pro Pro Tyr Gln Gly Pro Cys Thr Leu Gln Leu Arg 
            180                 185                 190         


Asp Pro Glu Gln Gln Met Glu Leu Asn Arg Glu Ser Val Arg Ala Pro 
        195                 200                 205             


Pro Asn Arg Thr Ile Phe Asp Ser Asp Leu Ile Asp Ile Ala Met Tyr 
    210                 215                 220                 


Ser Gly Gly Pro Cys Pro Pro Ser Ser Asn Ser Gly Ile Ser Ala Ser 
225                 230                 235                 240 


Thr Cys Ser Ser Asn Gly Arg Met Glu Gly Pro Pro Pro Thr Tyr Ser 
                245                 250                 255     


Glu Val Met Gly His His Pro Gly Ala Ser Phe Leu His His Gln Arg 
            260                 265                 270         


Ser Asn Ala His Arg Gly Ser Arg Leu Gln Phe Gln Gln Asn Asn Ala 
        275                 280                 285             


Glu Ser Thr Ile Val Pro Ile Lys Gly Lys Asp Arg Lys Pro Gly Asn 
    290                 295                 300                 


Leu Val 
305     


<210>  6601
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  6601

Met Pro Glu Ala Gly Phe Gln Ala Thr Asn Ala Phe Thr Glu Cys Lys 
1               5                   10                  15      


Phe Thr Cys Thr Ser Gly Lys Cys Leu Tyr Leu Gly Ser Leu Val Cys 
            20                  25                  30          


Asn Gln Gln Asn Asp Cys Gly Asp Asn Ser Asp Glu Glu Asn Cys Leu 
        35                  40                  45              


Leu Val Thr Glu His Pro Pro Pro Gly Ile Phe Asn Ser Glu Leu Glu 
    50                  55                  60                  


Phe Ala Gln Ile Ile Ile Ile Val Val Val Val Thr Val Met Val Val 
65                  70                  75                  80  


Val Ile Val Cys Leu Leu Asn His Tyr Lys Val Ser Thr Arg Ser Phe 
                85                  90                  95      


Ile Asn Arg Pro Asn Gln Ser Arg Arg Arg Glu Asp Gly Leu Pro Gln 
            100                 105                 110         


Ile Met His Ala Pro Arg Ser Arg Asp Arg Phe Thr Ala Pro Ser Phe 
        115                 120                 125             


Ile Gln Arg Asp Arg Phe Ser Arg Phe Gln Pro Thr Tyr Pro Tyr Val 
    130                 135                 140                 


Gln His Glu Ile Asp Leu Pro Pro Thr Ile Ser Leu Ser Asp Gly Glu 
145                 150                 155                 160 


Glu Pro Pro Pro Tyr Gln Gly Pro Cys Thr Leu Gln Leu Arg Asp Pro 
                165                 170                 175     


Glu Gln Gln Met Glu Leu Asn Arg Glu Ser Val Arg Ala Pro Pro Asn 
            180                 185                 190         


Arg Thr Ile Phe Asp Ser Asp Leu Ile Asp Ile Ala Met Tyr Ser Gly 
        195                 200                 205             


Gly Pro Cys Pro Pro Ser Ser Asn Ser Gly Ile Ser Ala Ser Thr Cys 
    210                 215                 220                 


Ser Ser Asn Gly Arg Met Glu Gly Pro Pro Pro Thr Tyr Ser Glu Val 
225                 230                 235                 240 


Met Gly His His Pro Gly Ala Ser Phe Leu His His Gln Arg Ser Asn 
                245                 250                 255     


Ala His Arg Gly Ser Arg Leu Gln Phe Gln Gln Asn Asn Ala Glu Ser 
            260                 265                 270         


Thr Ile Val Pro Ile Lys Gly Lys Asp Arg Lys Pro Gly Asn Leu Val 
        275                 280                 285             


<210>  6602
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  6602

Met Pro Glu Ala Gly Phe Gln Ala Thr Asn Ala Phe Thr Glu Cys Lys 
1               5                   10                  15      


Phe Thr Cys Thr Ser Gly Lys Cys Leu Tyr Leu Gly Ser Leu Val Cys 
            20                  25                  30          


Asn Gln Gln Asn Asp Cys Gly Asp Asn Ser Asp Glu Glu Asn Cys Leu 
        35                  40                  45              


Leu Val Thr Glu His Pro Pro Pro Gly Ile Phe Asn Ser Glu Leu Glu 
    50                  55                  60                  


Phe Ala Gln Ile Ile Ile Ile Val Val Val Val Thr Val Met Val Val 
65                  70                  75                  80  


Val Ile Val Cys Leu Leu Asn His Tyr Lys Val Ser Thr Arg Ser Phe 
                85                  90                  95      


Ile Asn Arg Pro Asn Gln Ser Arg Arg Arg Glu Asp Gly Leu Pro Gln 
            100                 105                 110         


Ile Met His Ala Pro Arg Ser Arg Asp Arg Phe Thr Ala Pro Ser Phe 
        115                 120                 125             


Ile Gln Arg Asp Arg Phe Ser Arg Phe Gln Pro Thr Tyr Pro Tyr Val 
    130                 135                 140                 


Gln His Glu Ile Asp Leu Pro Pro Thr Ile Ser Leu Ser Asp Gly Glu 
145                 150                 155                 160 


Glu Pro Pro Pro Tyr Gln Gly Pro Cys Thr Leu Gln Leu Arg Asp Pro 
                165                 170                 175     


Glu Gln Gln Met Glu Leu Asn Arg Glu Ser Val Arg Ala Pro Pro Asn 
            180                 185                 190         


Arg Thr Ile Phe Asp Ser Asp Leu Ile Asp Ile Ala Met Tyr Ser Gly 
        195                 200                 205             


Gly Pro Cys Pro Pro Ser Ser Asn Ser Gly Ile Ser Ala Ser Thr Cys 
    210                 215                 220                 


Ser Ser Asn Gly Arg Met Glu Gly Pro Pro Pro Thr Tyr Ser Glu Val 
225                 230                 235                 240 


Met Gly His His Pro Gly Ala Ser Phe Leu His His Gln Arg Ser Asn 
                245                 250                 255     


Ala His Arg Gly Ser Arg Leu Gln Phe Gln Gln Asn Asn Ala Glu Ser 
            260                 265                 270         


Thr Ile Val Pro Ile Lys Gly Lys Asp Arg Lys Pro Gly Asn Leu Val 
        275                 280                 285             


<210>  6603
<211>  676
<212>  PRT
<213>  Homo sapiens

<400>  6603

Met Ala Ala Asn Val Gly Ser Met Phe Gln Tyr Trp Lys Arg Phe Asp 
1               5                   10                  15      


Leu Gln Gln Leu Gln Arg Glu Leu Asp Ala Thr Ala Thr Val Leu Ala 
            20                  25                  30          


Asn Arg Gln Asp Glu Ser Glu Gln Ser Arg Lys Arg Leu Ile Glu Gln 
        35                  40                  45              


Ser Arg Glu Phe Lys Lys Asn Thr Pro Glu Asp Leu Arg Lys Gln Val 
    50                  55                  60                  


Ala Pro Leu Leu Lys Ser Phe Gln Gly Glu Ile Asp Ala Leu Ser Lys 
65                  70                  75                  80  


Arg Ser Lys Glu Ala Glu Ala Ala Phe Leu Asn Val Tyr Lys Arg Leu 
                85                  90                  95      


Ile Asp Val Pro Asp Pro Val Pro Ala Leu Asp Leu Gly Gln Gln Leu 
            100                 105                 110         


Gln Leu Lys Val Gln Arg Leu His Asp Ile Glu Thr Glu Asn Gln Lys 
        115                 120                 125             


Leu Arg Glu Thr Leu Glu Glu Tyr Asn Lys Glu Phe Ala Glu Val Lys 
    130                 135                 140                 


Asn Gln Glu Val Thr Ile Lys Ala Leu Lys Glu Lys Ile Arg Glu Tyr 
145                 150                 155                 160 


Glu Gln Thr Leu Lys Asn Gln Ala Glu Thr Ile Ala Leu Glu Lys Glu 
                165                 170                 175     


Gln Lys Leu Gln Asn Asp Phe Ala Glu Lys Glu Arg Lys Leu Gln Glu 
            180                 185                 190         


Thr Gln Met Ser Thr Thr Ser Lys Leu Glu Glu Ala Glu His Lys Val 
        195                 200                 205             


Gln Ser Leu Gln Thr Ala Leu Glu Lys Thr Arg Thr Glu Leu Phe Asp 
    210                 215                 220                 


Leu Lys Thr Lys Tyr Asp Glu Glu Thr Thr Ala Lys Ala Asp Glu Ile 
225                 230                 235                 240 


Glu Met Ile Met Thr Asp Leu Glu Arg Ala Asn Gln Arg Ala Glu Val 
                245                 250                 255     


Ala Gln Arg Glu Ala Glu Thr Leu Arg Glu Gln Leu Ser Ser Ala Asn 
            260                 265                 270         


His Ser Leu Gln Leu Ala Ser Gln Ile Gln Lys Ala Pro Asp Val Ala 
        275                 280                 285             


Ile Glu Val Leu Thr Arg Ser Ser Leu Glu Val Glu Leu Ala Ala Lys 
    290                 295                 300                 


Glu Arg Glu Ile Ala Gln Leu Val Glu Asp Val Gln Arg Leu Gln Ala 
305                 310                 315                 320 


Ser Leu Thr Lys Leu Arg Glu Asn Ser Ala Ser Gln Ile Ser Gln Leu 
                325                 330                 335     


Glu Gln Gln Leu Ser Ala Lys Asn Ser Thr Leu Lys Gln Leu Glu Glu 
            340                 345                 350         


Lys Leu Lys Gly Gln Ala Asp Tyr Glu Glu Val Lys Lys Glu Leu Asn 
        355                 360                 365             


Ile Leu Lys Ser Met Glu Phe Ala Pro Ser Glu Gly Ala Gly Thr Gln 
    370                 375                 380                 


Asp Ala Ala Lys Pro Leu Glu Val Leu Leu Leu Glu Lys Asn Arg Ser 
385                 390                 395                 400 


Leu Gln Ser Glu Asn Ala Ala Leu Arg Ile Ser Asn Ser Asp Leu Ser 
                405                 410                 415     


Gly Arg Cys Ala Glu Leu Gln Val Arg Ile Thr Glu Ala Val Ala Thr 
            420                 425                 430         


Ala Thr Glu Gln Arg Glu Leu Ile Ala Arg Leu Glu Gln Asp Leu Ser 
        435                 440                 445             


Ile Ile Gln Ser Ile Gln Arg Pro Asp Ala Glu Gly Ala Ala Glu His 
    450                 455                 460                 


Arg Leu Glu Lys Ile Pro Glu Pro Ile Lys Glu Ala Thr Ala Leu Phe 
465                 470                 475                 480 


Tyr Gly Pro Ala Ala Pro Ala Ser Gly Ala Leu Pro Glu Gly Gln Val 
                485                 490                 495     


Asp Ser Leu Leu Ser Ile Ile Ser Ser Gln Arg Glu Arg Phe Arg Ala 
            500                 505                 510         


Arg Asn Gln Glu Leu Glu Ala Glu Asn Arg Leu Ala Gln His Thr Leu 
        515                 520                 525             


Gln Ala Leu Gln Ser Glu Leu Asp Ser Leu Arg Ala Asp Asn Ile Lys 
    530                 535                 540                 


Leu Phe Glu Lys Ile Lys Phe Leu Gln Ser Tyr Pro Gly Arg Gly Ser 
545                 550                 555                 560 


Gly Ser Asp Asp Thr Glu Leu Arg Tyr Ser Ser Gln Tyr Glu Glu Arg 
                565                 570                 575     


Leu Asp Pro Phe Ser Ser Phe Ser Lys Arg Glu Arg Gln Arg Lys Tyr 
            580                 585                 590         


Leu Ser Leu Ser Pro Trp Asp Lys Ala Thr Leu Ser Met Gly Arg Leu 
        595                 600                 605             


Val Leu Ser Asn Lys Met Ala Arg Thr Ile Gly Phe Phe Tyr Thr Leu 
    610                 615                 620                 


Phe Leu His Cys Leu Val Phe Leu Val Leu Tyr Lys Leu Ala Trp Ser 
625                 630                 635                 640 


Glu Ser Met Glu Arg Asp Cys Ala Thr Phe Cys Ala Lys Lys Phe Ala 
                645                 650                 655     


Asp His Leu His Lys Phe His Glu Asn Asp Asn Gly Ala Ala Ala Gly 
            660                 665                 670         


Asp Leu Trp Gln 
        675     


<210>  6604
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  6604

Met Cys Gly Leu Gln Phe Ser Leu Pro Cys Leu Arg Leu Phe Leu Val 
1               5                   10                  15      


Val Thr Cys Tyr Leu Leu Leu Leu Leu His Lys Glu Ile Leu Gly Cys 
            20                  25                  30          


Ser Ser Val Cys Gln Leu Cys Thr Gly Arg Gln Ile Asn Cys Arg Asn 
        35                  40                  45              


Leu Gly Leu Ser Ser Ile Pro Lys Asn Phe Pro Glu Ser Thr Val Phe 
    50                  55                  60                  


Leu Tyr Leu Thr Gly Asn Asn Ile Ser Tyr Ile Asn Glu Ser Glu Leu 
65                  70                  75                  80  


Thr Gly Leu His Ser Leu Val Ala Leu Tyr Leu Asp Asn Ser Asn Ile 
                85                  90                  95      


Leu Tyr Val Tyr Pro Lys Ala Phe Val Gln Leu Arg His Leu Tyr Phe 
            100                 105                 110         


Leu Phe Leu Asn Asn Asn Phe Ile Lys Arg Leu Asp Pro Gly Ile Phe 
        115                 120                 125             


Lys Gly Leu Leu Asn Leu Arg Asn Leu Tyr Leu Gln Tyr Asn Gln Val 
    130                 135                 140                 


Ser Phe Val Pro Arg Gly Val Phe Asn Asp Leu Val Ser Val Gln Tyr 
145                 150                 155                 160 


Leu Asn Leu Gln Arg Asn Arg Leu Thr Val Leu Gly Ser Gly Thr Phe 
                165                 170                 175     


Val Gly Met Val Ala Leu Arg Ile Leu Asp Leu Ser Asn Asn Asn Ile 
            180                 185                 190         


Leu Arg Ile Ser Glu Ser Gly Phe Gln His Leu Glu Asn Leu Ala Cys 
        195                 200                 205             


Leu Tyr Leu Gly Ser Asn Asn Leu Thr Lys Val Pro Ser Asn Ala Phe 
    210                 215                 220                 


Glu Val Leu Lys Ser Leu Arg Arg Leu Ser Leu Ser His Asn Pro Ile 
225                 230                 235                 240 


Glu Ala Ile Gln Pro Phe Ala Phe Lys Gly Leu Ala Asn Leu Glu Tyr 
                245                 250                 255     


Leu Leu Leu Lys Asn Ser Arg Ile Arg Asn Val Thr Arg Asp Gly Phe 
            260                 265                 270         


Ser Gly Ile Asn Asn Leu Lys His Leu Ile Leu Ser His Asn Asp Leu 
        275                 280                 285             


Glu Asn Leu Asn Ser Asp Thr Phe Ser Leu Leu Lys Asn Leu Ile Tyr 
    290                 295                 300                 


Leu Lys Leu Asp Arg Asn Arg Ile Ile Ser Ile Asp Asn Asp Thr Phe 
305                 310                 315                 320 


Glu Asn Met Gly Ala Ser Leu Lys Ile Leu Asn Leu Ser Phe Asn Asn 
                325                 330                 335     


Leu Thr Ala Leu His Pro Arg Val Leu Lys Pro Leu Ser Ser Leu Ile 
            340                 345                 350         


His Leu Gln Ala Asn Ser Asn Pro Trp Glu Cys Asn Cys Lys Leu Leu 
        355                 360                 365             


Gly Leu Arg Asp Trp Leu Ala Ser Ser Ala Ile Thr Leu Asn Ile Tyr 
    370                 375                 380                 


Cys Gln Asn Pro Pro Ser Met Arg Gly Arg Ala Leu Arg Tyr Ile Asn 
385                 390                 395                 400 


Ile Thr Asn Cys Val Thr Ser Ser Ile Asn Val Ser Arg Ala Trp Ala 
                405                 410                 415     


Val Val Lys Ser Pro His Ile His His Lys Thr Thr Ala Leu Met Met 
            420                 425                 430         


Ala Trp His Lys Val Thr Thr Asn Gly Ser Pro Leu Glu Asn Thr Glu 
        435                 440                 445             


Thr Glu Asn Ile Thr Phe Trp Glu Arg Ile Pro Thr Ser Pro Ala Gly 
    450                 455                 460                 


Arg Phe Phe Gln Glu Asn Ala Phe Gly Asn Pro Leu Glu Thr Thr Ala 
465                 470                 475                 480 


Val Leu Pro Val Gln Ile Gln Leu Thr Thr Ser Val Thr Leu Asn Leu 
                485                 490                 495     


Glu Lys Asn Ser Ala Leu Pro Asn Asp Ala Ala Ser Met Ser Gly Lys 
            500                 505                 510         


Thr Ser Leu Ile Cys Thr Gln Glu Val Glu Lys Leu Asn Glu Ala Phe 
        515                 520                 525             


Asp Ile Leu Leu Ala Phe Phe Ile Leu Ala Cys Val Leu Ile Ile Phe 
    530                 535                 540                 


Leu Ile Tyr Lys Val Val Gln Phe Lys Gln Lys Leu Lys Ala Ser Glu 
545                 550                 555                 560 


Asn Ser Arg Glu Asn Arg Leu Glu Tyr Tyr Ser Phe Tyr Gln Ser Ala 
                565                 570                 575     


Arg Tyr Asn Val Thr Ala Ser Ile Cys Asn Thr Ser Pro Asn Ser Leu 
            580                 585                 590         


Glu Ser Pro Gly Leu Glu Gln Ile Arg Leu His Lys Gln Ile Val Pro 
        595                 600                 605             


Glu Asn Glu Ala Gln Val Ile Leu Phe Glu His Ser Ala Leu 
    610                 615                 620         


<210>  6605
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  6605

Met Ala Glu Gln Leu Ala Leu Val Ile Gly Gly Thr Ile Gly Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ile Gly Ala Ser Cys Cys Leu Trp Arg Arg Phe 
            20                  25                  30          


Cys Ala Thr Leu Thr Tyr Glu Glu Leu Pro Gly Thr Pro Ala Met Ala 
        35                  40                  45              


Thr Thr Ala Ala Ser Ser Gly Gln Arg Asp Arg Pro Cys Gln Pro His 
    50                  55                  60                  


Ala Arg Thr Gln Leu Ser Arg Pro Pro Ala Val Pro Phe Val Val Pro 
65                  70                  75                  80  


Pro Thr Leu Gln Gly Arg Asp Trp Val Pro Leu His Ser Gly Glu Trp 
                85                  90                  95      


Ala Asp Ala Pro Trp Asp Pro Cys Pro Ala Ser Glu Leu Leu Pro His 
            100                 105                 110         


Thr Ser Ser Gly Gly Leu Gly Asp Ala Cys Met Val Gly Ala Ile Asn 
        115                 120                 125             


Pro Glu Leu Tyr Lys Phe Pro Glu Asp Lys Ser Glu Thr Asp Phe Pro 
    130                 135                 140                 


Asp Gly Cys Leu Gly Arg Leu Trp Phe Ser Val Glu Tyr Glu Gln Glu 
145                 150                 155                 160 


Ala Glu Arg Leu Leu Val Gly Leu Ile Lys Ala Gln His Leu Gln Ala 
                165                 170                 175     


Pro Ser Glu Thr Cys Ser Pro Leu Val Lys Leu Tyr Leu Leu Pro Asp 
            180                 185                 190         


Glu Arg Arg Phe Leu Gln Ser Lys Thr Lys Arg Lys Thr Ser Asn Pro 
        195                 200                 205             


Gln Phe Asp Glu His Phe Ile Phe Gln Val Ser Ser Lys Thr Ile Thr 
    210                 215                 220                 


Gln Arg Val Leu Lys Phe Ser Val Tyr His Val Asp Arg Gln Arg Lys 
225                 230                 235                 240 


His Gln Leu Leu Gly Gln Val Leu Phe Pro Leu Lys Asn Glu Thr Leu 
                245                 250                 255     


Val Gly Asp Cys Arg Arg Val Ile Trp Arg Asp Leu Glu Ala Glu Ser 
            260                 265                 270         


Leu Glu Pro Pro Ser Glu Phe Gly Asp Leu Gln Phe Cys Leu Ser Tyr 
        275                 280                 285             


Asn Asp Tyr Leu Ser Arg Leu Thr Val Val Val Leu Arg Ala Lys Gly 
    290                 295                 300                 


Leu Arg Leu Gln Glu Asp Arg Gly Ile Val Ser Val Phe Val Lys Val 
305                 310                 315                 320 


Ser Leu Met Asn His Asn Lys Phe Val Lys Cys Lys Lys Thr Ser Ala 
                325                 330                 335     


Val Leu Gly Ser Ile Asn Pro Val Tyr Asn Glu Thr Phe Ser Phe Lys 
            340                 345                 350         


Ala Asp Ala Thr Glu Leu Asp Thr Ala Ser Leu Ser Leu Thr Val Val 
        355                 360                 365             


Gln Asn Met Glu Gly Asp Lys Gln Ala Thr Thr Val Glu Leu Phe Leu 
    370                 375                 380                 


Phe His Leu Thr Ser Gly 
385                 390 


<210>  6606
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  6606

Met Arg Ser Gly Glu Glu Leu Asp Gly Phe Glu Gly Glu Ala Ser Ser 
1               5                   10                  15      


Thr Ser Met Ile Ser Gly Ala Ser Ser Pro Tyr Gln Pro Thr Thr Glu 
            20                  25                  30          


Pro Val Ser Gln Arg Arg Gly Leu Ala Gly Leu Arg Cys Asp Pro Asp 
        35                  40                  45              


Tyr Leu Arg Gly Ala Leu Gly Arg Leu Lys Val Ala Gln Val Ile Leu 
    50                  55                  60                  


Ala Leu Ile Ala Phe Ile Cys Ile Glu Thr Ile Met Ala Cys Ser Pro 
65                  70                  75                  80  


Cys Glu Gly Leu Tyr Phe Phe Glu Phe Val Ser Cys Ser Ala Phe Val 
                85                  90                  95      


Val Thr Gly Val Leu Leu Ile Met Phe Ser Leu Asn Leu His Met Arg 
            100                 105                 110         


Ile Pro Gln Ile Asn Trp Asn Leu Thr Asp Leu Val Asn Thr Gly Leu 
        115                 120                 125             


Ser Ala Phe Leu Phe Phe Ile Ala Ser Ile Val Leu Ala Ala Leu Asn 
    130                 135                 140                 


His Arg Ala Gly Ala Glu Ile Ala Ala Val Ile Phe Gly Phe Leu Ala 
145                 150                 155                 160 


Thr Ala Ala Tyr Ala Val Asn Thr Phe Leu Ala Val Gln Lys Trp Arg 
                165                 170                 175     


Val Ser Val Arg Gln Gln Ser Thr Asn Asp Tyr Ile Arg Ala Arg Thr 
            180                 185                 190         


Glu Ser Arg Asp Val Asp Ser Arg Pro Glu Ile Gln Arg Leu Asp Thr 
        195                 200                 205             


<210>  6607
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  6607

Met Glu Pro Ala Ala Ala Leu His Phe Ser Leu Pro Ala Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Gly 
            20                  25                  30          


Leu Gly Ser Lys Pro Leu Ile Glu Ile Lys Ala Gln Glu Asp Gly Ser 
        35                  40                  45              


Ile Trp Leu Glu Cys Ile Ser Gly Gly Trp Tyr Pro Glu Pro Leu Thr 
    50                  55                  60                  


Val Trp Arg Asp Pro Tyr Gly Glu Val Val Pro Ala Leu Lys Glu Val 
65                  70                  75                  80  


Ser Ile Ala Asp Ala Asp Gly Leu Phe Met Val Thr Thr Ala Val Ile 
                85                  90                  95      


Ile Arg Asp Lys Tyr Val Arg Asn Val Ser Cys Ser Val Asn Asn Thr 
            100                 105                 110         


Leu Leu Gly Gln Glu Lys Glu Thr Val Ile Phe Ile Pro Glu Ser Phe 
        115                 120                 125             


Met Pro Ser Ala Ser Pro Trp Met Val Ala Leu Ala Val Ile Leu Thr 
    130                 135                 140                 


Ala Ser Pro Trp Met Val Ser Met Thr Val Ile Leu Ala Val Phe Ile 
145                 150                 155                 160 


Ile Phe Met Ala Val Ser Ile Cys Cys Ile Lys Lys Leu Gln Arg Glu 
                165                 170                 175     


Lys Lys Ile Leu Ser Gly Glu Lys Lys Val Glu Gln Glu Glu Lys Glu 
            180                 185                 190         


Ile Ala Gln Gln Leu Gln Glu Glu Leu Arg Trp Arg Arg Thr Phe Leu 
        195                 200                 205             


His Ala Ala Asp Val Val Leu Asp Pro Asp Thr Ala His Pro Glu Leu 
    210                 215                 220                 


Phe Leu Ser Glu Asp Arg Arg Ser Val Arg Arg Gly Pro Tyr Arg Gln 
225                 230                 235                 240 


Arg Val Pro Asp Asn Pro Glu Arg Phe Asp Ser Gln Pro Cys Val Leu 
                245                 250                 255     


Gly Trp Glu Ser Phe Ala Ser Gly Lys His Tyr Trp Glu Val Glu Val 
            260                 265                 270         


Glu Asn Val Met Val Trp Thr Val Gly Val Cys Arg His Ser Val Glu 
        275                 280                 285             


Arg Lys Gly Glu Val Leu Leu Ile Pro Gln Asn Gly Phe Trp Thr Leu 
    290                 295                 300                 


Glu Met Phe Gly Asn Gln Tyr Arg Ala Leu Ser Ser Pro Glu Arg Ile 
305                 310                 315                 320 


Leu Pro Leu Lys Glu Ser Leu Cys Arg Val Gly Val Phe Leu Asp Tyr 
                325                 330                 335     


Glu Ala Gly Asp Val Ser Phe Tyr Asn Met Arg Asp Arg Ser His Ile 
            340                 345                 350         


Tyr Thr Cys Pro Arg Ser Ala Phe Thr Val Pro Val Arg Pro Phe Phe 
        355                 360                 365             


Arg Leu Gly Ser Asp Asp Ser Pro Ile Phe Ile Cys Pro Ala Leu Thr 
    370                 375                 380                 


Gly Ala Ser Gly Val Met Val Pro Glu Glu Gly Leu Lys Leu His Arg 
385                 390                 395                 400 


Val Gly Thr His Gln Ser Leu 
                405         


<210>  6608
<211>  1505
<212>  PRT
<213>  Homo sapiens

<400>  6608

Met Leu Cys Val Ala Gly Ala Arg Leu Lys Arg Glu Leu Asp Ala Thr 
1               5                   10                  15      


Ala Thr Val Leu Ala Asn Arg Gln Asp Glu Ser Glu Gln Ser Arg Lys 
            20                  25                  30          


Arg Leu Ile Glu Gln Ser Arg Glu Phe Lys Lys Asn Thr Pro Glu Asp 
        35                  40                  45              


Leu Arg Lys Gln Val Ala Pro Leu Leu Lys Ser Phe Gln Gly Glu Ile 
    50                  55                  60                  


Asp Ala Leu Ser Lys Arg Ser Lys Glu Ala Glu Ala Ala Phe Leu Asn 
65                  70                  75                  80  


Val Tyr Lys Arg Leu Ile Asp Val Pro Asp Pro Val Pro Ala Leu Asp 
                85                  90                  95      


Leu Gly Gln Gln Leu Gln Leu Lys Val Gln Arg Leu His Asp Ile Glu 
            100                 105                 110         


Thr Glu Asn Gln Lys Leu Arg Glu Thr Leu Glu Glu Tyr Asn Lys Glu 
        115                 120                 125             


Phe Ala Glu Val Lys Asn Gln Glu Val Thr Ile Lys Ala Leu Lys Glu 
    130                 135                 140                 


Lys Ile Arg Glu Tyr Glu Gln Thr Leu Lys Asn Gln Ala Glu Thr Ile 
145                 150                 155                 160 


Ala Leu Glu Lys Glu Gln Lys Leu Gln Asn Asp Phe Ala Glu Lys Glu 
                165                 170                 175     


Arg Lys Leu Gln Glu Thr Gln Met Ser Thr Thr Ser Lys Leu Glu Glu 
            180                 185                 190         


Ala Glu His Lys Val Gln Ser Leu Gln Thr Ala Leu Glu Lys Thr Arg 
        195                 200                 205             


Thr Glu Leu Phe Asp Leu Lys Thr Lys Tyr Asp Glu Glu Thr Thr Ala 
    210                 215                 220                 


Lys Ala Asp Glu Ile Glu Met Ile Met Thr Asp Leu Glu Arg Ala Asn 
225                 230                 235                 240 


Gln Arg Ala Glu Val Ala Gln Arg Glu Ala Glu Thr Leu Arg Glu Gln 
                245                 250                 255     


Leu Ser Ser Ala Asn His Ser Leu Gln Leu Ala Ser Gln Ile Gln Lys 
            260                 265                 270         


Ala Pro Asp Val Glu Gln Ala Ile Glu Val Leu Thr Arg Ser Ser Leu 
        275                 280                 285             


Glu Val Glu Leu Ala Ala Lys Glu Arg Glu Ile Ala Gln Leu Val Glu 
    290                 295                 300                 


Asp Val Gln Arg Leu Gln Ala Ser Leu Thr Lys Leu Arg Glu Asn Ser 
305                 310                 315                 320 


Ala Ser Gln Ile Ser Gln Leu Glu Gln Gln Leu Ser Ala Lys Asn Ser 
                325                 330                 335     


Thr Leu Lys Gln Leu Glu Glu Lys Leu Lys Gly Gln Ala Asp Tyr Glu 
            340                 345                 350         


Glu Val Lys Lys Glu Leu Asn Ile Leu Lys Ser Met Glu Phe Ala Pro 
        355                 360                 365             


Ser Glu Gly Ala Gly Thr Gln Asp Ala Ala Lys Pro Leu Glu Val Leu 
    370                 375                 380                 


Leu Leu Glu Lys Asn Arg Ser Leu Gln Ser Glu Asn Ala Ala Leu Arg 
385                 390                 395                 400 


Ile Ser Asn Ser Asp Leu Ser Gly Ser Ala Arg Arg Lys Gly Lys Asp 
                405                 410                 415     


Gln Pro Glu Ser Arg Arg Pro Gly Ser Leu Pro Ala Pro Pro Pro Ser 
            420                 425                 430         


Gln Leu Pro Arg Asn Pro Gly Glu Gln Ala Ser Asn Thr Asn Gly Thr 
        435                 440                 445             


His Gln Phe Ser Pro Ala Gly Leu Ser Gln Asp Phe Phe Ser Ser Ser 
    450                 455                 460                 


Leu Ala Ser Pro Ser Leu Pro Leu Ala Ser Thr Gly Lys Phe Ala Leu 
465                 470                 475                 480 


Asn Ser Leu Leu Gln Arg Gln Leu Met Gln Ser Phe Tyr Ser Lys Ala 
                485                 490                 495     


Met Gln Glu Ala Gly Ser Thr Ser Met Ile Phe Ser Thr Gly Pro Tyr 
            500                 505                 510         


Ser Thr Asn Ser Ile Ser Ser Gln Ser Pro Leu Gln Gln Ser Pro Asp 
        515                 520                 525             


Val Asn Gly Met Ala Pro Ser Pro Ser Gln Ser Glu Ser Ala Gly Ser 
    530                 535                 540                 


Val Ser Glu Gly Glu Glu Met Asp Thr Ala Glu Ile Ala Arg Gln Val 
545                 550                 555                 560 


Lys Glu Gln Leu Ile Lys His Asn Ile Gly Gln Arg Ile Phe Gly His 
                565                 570                 575     


Tyr Val Leu Gly Leu Ser Gln Gly Ser Val Ser Glu Ile Leu Ala Arg 
            580                 585                 590         


Pro Lys Pro Trp Asn Lys Leu Thr Val Arg Gly Lys Glu Pro Phe His 
        595                 600                 605             


Lys Met Lys Gln Phe Leu Ser Asp Glu Gln Asn Ile Leu Ala Leu Arg 
    610                 615                 620                 


Ser Ile Gln Gly Arg Gln Arg Glu Asn Pro Gly Gln Ser Leu Asn Arg 
625                 630                 635                 640 


Leu Phe Gln Glu Val Pro Lys Arg Arg Asn Gly Ser Glu Gly Asn Ile 
                645                 650                 655     


Thr Thr Arg Ile Arg Ala Ser Glu Thr Gly Ser Asp Glu Ala Ile Lys 
            660                 665                 670         


Ser Ile Leu Glu Gln Ala Lys Arg Glu Leu Gln Val Gln Lys Thr Ala 
        675                 680                 685             


Glu Pro Ala Gln Pro Ser Ser Ala Ser Gly Ser Gly Asn Ser Asp Asp 
    690                 695                 700                 


Ala Ile Arg Ser Ile Leu Gln Gln Ala Arg Arg Glu Met Glu Ala Gln 
705                 710                 715                 720 


Gln Ala Ala Leu Asp Pro Ala Leu Lys Gln Ala Pro Leu Ser Gln Ser 
                725                 730                 735     


Asp Ile Thr Ile Leu Thr Pro Lys Leu Leu Ser Thr Ser Pro Met Pro 
            740                 745                 750         


Thr Val Ser Ser Tyr Pro Pro Leu Ala Ile Ser Leu Lys Lys Pro Ser 
        755                 760                 765             


Ala Ala Pro Glu Ala Gly Ala Ser Ala Leu Pro Asn Pro Pro Ala Leu 
    770                 775                 780                 


Lys Lys Glu Ala Gln Asp Ala Pro Gly Leu Asp Pro Gln Gly Ala Ala 
785                 790                 795                 800 


Asp Cys Ala Gln Gly Val Leu Arg Gln Val Lys Asn Glu Val Gly Arg 
                805                 810                 815     


Ser Gly Ala Trp Lys Asp His Trp Trp Ser Ala Val Gln Pro Glu Arg 
            820                 825                 830         


Arg Asn Ala Ala Ser Ser Glu Glu Ala Lys Ala Glu Glu Thr Gly Gly 
        835                 840                 845             


Gly Lys Glu Lys Gly Ser Gly Gly Ser Gly Gly Gly Ser Gln Pro Arg 
    850                 855                 860                 


Ala Glu Arg Ser Gln Leu Gln Gly Pro Ser Ser Ser Glu Tyr Trp Lys 
865                 870                 875                 880 


Glu Trp Pro Ser Ala Glu Ser Pro Tyr Ser Gln Ser Ser Glu Leu Ser 
                885                 890                 895     


Leu Thr Gly Ala Ser Arg Ser Glu Thr Pro Gln Asn Ser Pro Leu Pro 
            900                 905                 910         


Ser Ser Pro Ile Val Pro Met Ser Lys Pro Thr Lys Pro Ser Val Pro 
        915                 920                 925             


Pro Leu Thr Pro Glu Gln Tyr Glu Val Tyr Met Tyr Gln Glu Val Asp 
    930                 935                 940                 


Thr Ile Glu Leu Thr Arg Gln Val Lys Glu Lys Leu Ala Lys Asn Gly 
945                 950                 955                 960 


Ile Cys Gln Arg Ile Phe Gly Glu Lys Val Leu Gly Leu Ser Gln Gly 
                965                 970                 975     


Ser Val Ser Asp Met Leu Ser Arg Pro Lys Pro Trp Ser Lys Leu Thr 
            980                 985                 990         


Gln Lys Gly Arg Glu Pro Phe Ile  Arg Met Gln Leu Trp  Leu Asn Gly 
        995                 1000                 1005             


Glu Leu  Gly Gln Gly Val Leu  Pro Val Gln Gly Gln  Gln Gln Gly 
    1010                 1015                 1020             


Pro Val  Leu His Ser Val Thr  Ser Leu Gln Asp Pro  Leu Gln Gln 
    1025                 1030                 1035             


Gly Cys  Val Ser Ser Glu Ser  Thr Pro Lys Thr Ser  Ala Ser Cys 
    1040                 1045                 1050             


Ser Pro  Ala Pro Glu Ser Pro  Met Ser Ser Ser Glu  Ser Val Lys 
    1055                 1060                 1065             


Ser Leu  Thr Glu Leu Val Gln  Gln Pro Cys Pro Pro  Ile Glu Ala 
    1070                 1075                 1080             


Ser Lys  Asp Ser Lys Pro Pro  Glu Pro Ser Asp Pro  Pro Ala Ser 
    1085                 1090                 1095             


Asp Ser  Gln Pro Thr Thr Pro  Leu Pro Leu Ser Gly  His Ser Ala 
    1100                 1105                 1110             


Leu Ser  Ile Gln Glu Leu Val  Ala Met Ser Pro Glu  Leu Asp Thr 
    1115                 1120                 1125             


Tyr Gly  Ile Thr Lys Arg Val  Lys Glu Val Leu Thr  Asp Asn Asn 
    1130                 1135                 1140             


Leu Gly  Gln Arg Leu Phe Gly  Glu Thr Ile Leu Gly  Leu Thr Gln 
    1145                 1150                 1155             


Gly Ser  Val Ser Asp Leu Leu  Ala Arg Pro Lys Pro  Trp His Lys 
    1160                 1165                 1170             


Leu Ser  Leu Lys Gly Arg Glu  Pro Phe Val Arg Met  Gln Leu Trp 
    1175                 1180                 1185             


Leu Asn  Asp Pro Asn Asn Val  Glu Lys Leu Met Asp  Met Lys Arg 
    1190                 1195                 1200             


Met Glu  Lys Lys Ala Tyr Met  Lys Arg Arg His Ser  Ser Val Ser 
    1205                 1210                 1215             


Asp Ser  Gln Pro Cys Glu Pro  Pro Ser Val Gly Thr  Glu Tyr Ser 
    1220                 1225                 1230             


Gln Gly  Ala Ser Pro Gln Pro  Gln His Gln Leu Lys  Lys Pro Arg 
    1235                 1240                 1245             


Val Val  Leu Ala Pro Glu Glu  Lys Glu Ala Leu Lys  Arg Ala Tyr 
    1250                 1255                 1260             


Gln Gln  Lys Pro Tyr Pro Ser  Pro Lys Thr Ile Glu  Asp Leu Ala 
    1265                 1270                 1275             


Thr Gln  Leu Asn Leu Lys Thr  Ser Thr Val Ile Asn  Trp Phe His 
    1280                 1285                 1290             


Asn Tyr  Arg Ser Arg Ile Arg  Arg Glu Leu Phe Ile  Glu Glu Ile 
    1295                 1300                 1305             


Gln Ala  Gly Ser Gln Gly Gln  Ala Gly Ala Ser Asp  Ser Pro Ser 
    1310                 1315                 1320             


Ala Arg  Ser Gly Arg Ala Ala  Pro Ser Ser Glu Gly  Asp Ser Cys 
    1325                 1330                 1335             


Asp Gly  Val Glu Ala Thr Glu  Gly Pro Gly Ser Ala  Asp Thr Glu 
    1340                 1345                 1350             


Glu Pro  Lys Ser Gln Gly Glu  Ala Glu Arg Glu Glu  Val Pro Arg 
    1355                 1360                 1365             


Pro Ala  Glu Gln Thr Glu Pro  Pro Pro Ser Gly Thr  Pro Gly Pro 
    1370                 1375                 1380             


Asp Asp  Ala Arg Asp Asp Asp  His Glu Gly Gly Pro  Val Glu Gly 
    1385                 1390                 1395             


Pro Gly  Pro Leu Pro Ser Pro  Ala Ser Ala Thr Ala  Thr Ala Ala 
    1400                 1405                 1410             


Pro Ala  Ala Pro Glu Asp Ala  Ala Thr Ser Ala Ala  Ala Ala Pro 
    1415                 1420                 1425             


Gly Glu  Gly Pro Ala Ala Pro  Ser Ser Ala Pro Pro  Pro Ser Asn 
    1430                 1435                 1440             


Ser Ser  Ser Ser Ser Ala Pro  Arg Arg Pro Ser Ser  Leu Gln Ser 
    1445                 1450                 1455             


Leu Phe  Gly Leu Pro Glu Ala  Ala Gly Ala Arg Asp  Ser Arg Asp 
    1460                 1465                 1470             


Asn Pro  Leu Arg Lys Lys Lys  Ala Ala Asn Leu Asn  Ser Ile Ile 
    1475                 1480                 1485             


His Arg  Leu Glu Lys Ala Ala  Ser Arg Glu Glu Pro  Ile Glu Trp 
    1490                 1495                 1500             


Glu Phe  
    1505 


<210>  6609
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  6609

Met Trp Pro Pro Asp Pro Asp Pro Asp Pro Asp Pro Glu Pro Ala Gly 
1               5                   10                  15      


Gly Ser Arg Pro Gly Pro Ala Val Pro Gly Leu Arg Ala Leu Leu Pro 
            20                  25                  30          


Ala Arg Ala Phe Leu Cys Ser Leu Lys Gly Arg Leu Leu Leu Ala Glu 
        35                  40                  45              


Ser Gly Leu Ser Phe Ile Thr Phe Ile Cys Tyr Val Ala Ser Ser Ala 
    50                  55                  60                  


Ser Ala Phe Leu Thr Ala Pro Leu Leu Glu Phe Leu Leu Ala Leu Tyr 
65                  70                  75                  80  


Phe Leu Phe Ala Asp Ala Met Gln Leu Asn Asp Lys Trp Gln Gly Leu 
                85                  90                  95      


Cys Trp Pro Met Met Asp Phe Leu Arg Cys Val Thr Ala Ala Leu Ile 
            100                 105                 110         


Tyr Phe Ala Ile Ser Ile Thr Ala Ile Ala Lys Tyr Ser Asp Gly Ala 
        115                 120                 125             


Ser Lys Ala Ala Gly Val Phe Gly Phe Phe Ala Thr Ile Val Phe Ala 
    130                 135                 140                 


Thr Asp Phe Tyr Leu Ile Phe Asn Asp Val Ala Lys Phe Leu Lys Gln 
145                 150                 155                 160 


Gly Asp Ser Ala Asp Glu Thr Thr Ala His Lys Thr Glu Glu Glu Asn 
                165                 170                 175     


Ser Asp Ser Asp Ser Asp 
            180         


<210>  6610
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  6610

Met Trp Pro Pro Asp Pro Asp Pro Asp Pro Asp Pro Glu Pro Ala Gly 
1               5                   10                  15      


Gly Ser Arg Pro Gly Pro Ala Val Pro Gly Leu Arg Ala Leu Leu Pro 
            20                  25                  30          


Ala Arg Ala Phe Leu Cys Ser Leu Lys Gly Arg Leu Leu Leu Ala Glu 
        35                  40                  45              


Ser Gly Leu Ser Phe Ile Thr Phe Ile Cys Tyr Val Ala Ser Ser Ala 
    50                  55                  60                  


Ser Ala Phe Leu Thr Ala Pro Leu Leu Glu Phe Leu Leu Ala Leu Tyr 
65                  70                  75                  80  


Phe Leu Phe Ala Asp Ala Met Gln Leu Asn Asp Lys Trp Gln Gly Leu 
                85                  90                  95      


Cys Trp Pro Met Met Asp Phe Leu Arg Cys Val Thr Ala Ala Leu Ile 
            100                 105                 110         


Tyr Phe Ala Ile Ser Ile Thr Ala Ile Ala Lys Tyr Ser Asp Gly Ala 
        115                 120                 125             


Ser Lys Ala Ala Gly Val Phe Gly Phe Phe Ala Thr Ile Val Phe Ala 
    130                 135                 140                 


Thr Asp Phe Tyr Leu Ile Phe Asn Asp Val Ala Lys Phe Leu Lys Gln 
145                 150                 155                 160 


Gly Asp Ser Ala Asp Glu Thr Thr Ala His Lys Thr Glu Glu Glu Asn 
                165                 170                 175     


Ser Asp Ser Asp Ser Asp 
            180         


<210>  6611
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  6611

Met Glu Leu Pro Ser Gly Pro Gly Pro Glu Arg Leu Phe Asp Ser His 
1               5                   10                  15      


Arg Leu Pro Gly Asp Cys Phe Leu Leu Leu Val Leu Leu Leu Tyr Ala 
            20                  25                  30          


Pro Val Gly Phe Cys Leu Leu Val Leu Arg Leu Phe Leu Gly Ile His 
        35                  40                  45              


Val Phe Leu Val Ser Cys Ala Leu Pro Asp Ser Val Leu Arg Arg Phe 
    50                  55                  60                  


Val Val Arg Thr Met Cys Ala Val Leu Gly Leu Val Ala Arg Gln Glu 
65                  70                  75                  80  


Asp Ser Gly Leu Arg Asp His Ser Val Arg Val Leu Ile Ser Asn His 
                85                  90                  95      


Val Thr Pro Phe Asp His Asn Ile Val Asn Leu Leu Thr Thr Cys Ser 
            100                 105                 110         


Thr Pro Leu Leu Asn Ser Pro Pro Ser Phe Val Cys Trp Ser Arg Gly 
        115                 120                 125             


Phe Met Glu Met Asn Gly Arg Gly Glu Leu Val Glu Ser Leu Lys Arg 
    130                 135                 140                 


Phe Cys Ala Ser Thr Arg Leu Pro Pro Thr Pro Leu Leu Leu Phe Pro 
145                 150                 155                 160 


Glu Glu Glu Ala Thr Asn Gly Arg Glu Gly Leu Leu Arg Phe Ser Ser 
                165                 170                 175     


Trp Pro Phe Ser Ile Gln Asp Val Val Gln Pro Leu Thr Leu Gln Val 
            180                 185                 190         


Gln Arg Pro Leu Val Ser Val Thr Val Ser Asp Ala Ser Trp Val Ser 
        195                 200                 205             


Glu Leu Leu Trp Ser Leu Phe Val Pro Phe Thr Val Tyr Gln Val Arg 
    210                 215                 220                 


Trp Leu Arg Pro Val His Arg Gln Leu Gly Glu Ala Asn Glu Glu Phe 
225                 230                 235                 240 


Ala Leu Arg Val Gln Gln Leu Val Ala Lys Glu Leu Gly Gln Thr Gly 
                245                 250                 255     


Thr Arg Leu Thr Pro Ala Asp Lys Ala Glu His Met Lys Arg Gln Arg 
            260                 265                 270         


His Pro Arg Leu Arg Pro Gln Ser Ala Gln Ser Ser Phe Pro Pro Ser 
        275                 280                 285             


Pro Gly Pro Ser Pro Asp Val Gln Leu Ala Thr Leu Ala Gln Arg Val 
    290                 295                 300                 


Lys Glu Val Leu Pro His Val Pro Leu Gly Val Ile Gln Arg Asp Leu 
305                 310                 315                 320 


Ala Lys Thr Gly Cys Val Asp Leu Thr Ile Thr Asn Leu Leu Glu Gly 
                325                 330                 335     


Ala Val Ala Phe Met Pro Glu Asp Ile Thr Lys Gly Thr Gln Ser Leu 
            340                 345                 350         


Pro Thr Ala Ser Ala Ser Lys Phe Pro Ser Ser Gly Pro Val Thr Pro 
        355                 360                 365             


Gln Pro Thr Ala Leu Thr Phe Ala Lys Ser Ser Trp Ala Arg Gln Glu 
    370                 375                 380                 


Ser Leu Gln Glu Arg Lys Gln Ala Leu Tyr Glu Tyr Ala Arg Arg Arg 
385                 390                 395                 400 


Phe Thr Glu Arg Arg Ala Gln Glu Ala Asp 
                405                 410 


<210>  6612
<211>  553
<212>  PRT
<213>  Homo sapiens

<400>  6612

Met Ala Lys Asn Arg Arg Asp Arg Asn Ser Trp Gly Gly Phe Ser Glu 
1               5                   10                  15      


Lys Thr Tyr Glu Trp Ser Ser Glu Glu Glu Glu Pro Val Lys Lys Ala 
            20                  25                  30          


Gly Pro Val Gln Val Leu Ile Val Lys Asp Asp His Ser Phe Glu Leu 
        35                  40                  45              


Asp Glu Thr Ala Leu Asn Arg Ile Leu Leu Ser Glu Ala Val Arg Asp 
    50                  55                  60                  


Lys Glu Val Val Ala Val Ser Val Ala Gly Ala Phe Arg Lys Gly Lys 
65                  70                  75                  80  


Ser Phe Leu Met Asp Phe Met Leu Arg Tyr Met Tyr Asn Gln Glu Ser 
                85                  90                  95      


Val Asp Trp Val Gly Asp Tyr Asn Glu Pro Leu Thr Gly Phe Ser Trp 
            100                 105                 110         


Arg Gly Gly Ser Glu Arg Glu Thr Thr Gly Ile Gln Ile Trp Ser Glu 
        115                 120                 125             


Ile Phe Leu Ile Asn Lys Pro Asp Gly Lys Lys Val Ala Val Leu Leu 
    130                 135                 140                 


Met Asp Thr Gln Gly Thr Phe Asp Ser Gln Ser Thr Leu Arg Asp Ser 
145                 150                 155                 160 


Ala Thr Val Phe Ala Leu Ser Thr Met Ile Ser Ser Ile Gln Val Tyr 
                165                 170                 175     


Asn Leu Ser Gln Asn Val Gln Glu Asp Asp Leu Gln His Leu Gln Leu 
            180                 185                 190         


Phe Thr Glu Tyr Gly Arg Leu Ala Met Glu Glu Thr Phe Leu Lys Pro 
        195                 200                 205             


Phe Gln Ser Leu Ile Phe Leu Val Arg Asp Trp Ser Phe Pro Tyr Glu 
    210                 215                 220                 


Phe Ser Tyr Gly Ala Asp Gly Gly Ala Lys Phe Leu Glu Lys Arg Leu 
225                 230                 235                 240 


Lys Val Ser Gly Asn Gln His Glu Glu Leu Gln Asn Val Arg Lys His 
                245                 250                 255     


Ile His Ser Cys Phe Thr Asn Ile Ser Cys Phe Leu Leu Pro His Pro 
            260                 265                 270         


Gly Leu Lys Val Ala Thr Asn Pro Asn Phe Asp Gly Lys Leu Lys Glu 
        275                 280                 285             


Ile Asp Asp Glu Phe Ile Lys Asn Leu Lys Ile Leu Ile Pro Trp Leu 
    290                 295                 300                 


Leu Ser Pro Glu Ser Leu Asp Ile Lys Glu Ile Asn Gly Asn Lys Ile 
305                 310                 315                 320 


Thr Cys Arg Gly Leu Val Glu Tyr Phe Lys Ala Tyr Ile Lys Ile Tyr 
                325                 330                 335     


Gln Gly Glu Glu Leu Pro His Pro Lys Ser Met Leu Gln Ala Thr Ala 
            340                 345                 350         


Glu Ala Asn Asn Leu Ala Ala Val Ala Thr Ala Lys Asp Thr Tyr Asn 
        355                 360                 365             


Lys Lys Met Glu Glu Ile Cys Gly Gly Asp Lys Pro Phe Leu Ala Pro 
    370                 375                 380                 


Asn Asp Leu Gln Thr Lys His Leu Gln Leu Lys Glu Glu Ser Val Lys 
385                 390                 395                 400 


Leu Phe Arg Gly Val Lys Lys Met Gly Gly Glu Glu Phe Ser Arg Arg 
                405                 410                 415     


Tyr Leu Gln Gln Leu Glu Ser Glu Ile Asp Glu Leu Tyr Ile Gln Tyr 
            420                 425                 430         


Ile Lys His Asn Asp Ser Lys Asn Ile Phe His Ala Ala Arg Thr Pro 
        435                 440                 445             


Ala Thr Leu Phe Val Val Ile Phe Ile Thr Tyr Val Ile Ala Gly Val 
    450                 455                 460                 


Thr Gly Phe Ile Gly Leu Asp Ile Ile Ala Ser Leu Cys Asn Met Ile 
465                 470                 475                 480 


Met Gly Leu Thr Leu Ile Thr Leu Cys Thr Trp Ala Tyr Ile Arg Tyr 
                485                 490                 495     


Ser Gly Glu Tyr Arg Glu Leu Gly Ala Val Ile Asp Gln Val Ala Ala 
            500                 505                 510         


Ala Leu Trp Asp Gln Ala Leu Tyr Lys Leu Tyr Ser Ala Ala Ala Thr 
        515                 520                 525             


His Arg His Leu Tyr His Gln Ala Phe Pro Thr Pro Lys Ser Glu Ser 
    530                 535                 540                 


Thr Glu Gln Ser Glu Lys Lys Lys Met 
545                 550             


<210>  6613
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  6613

Met Ser Tyr Tyr Gly Ser Tyr Tyr Gly Gly Leu Gly Tyr Gly Cys Gly 
1               5                   10                  15      


Gly Phe Gly Gly Leu Gly Tyr Gly Tyr Gly Cys Gly Cys Gly Ser Phe 
            20                  25                  30          


Arg Arg Leu Gly Ser Gly Cys Gly Tyr Gly Gly Tyr Gly Tyr Gly Ser 
        35                  40                  45              


Gly Phe Gly Gly Tyr Gly Tyr Gly Ser Gly Phe Gly Gly Tyr Gly Tyr 
    50                  55                  60                  


Gly Cys Tyr Arg Pro Ser Tyr Tyr Gly Gly Tyr Gly Phe Ser Gly Phe 
65                  70                  75                  80  


Tyr 
    


<210>  6614
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  6614

Met Asp Asn Val Gln Pro Lys Ile Lys His Arg Pro Phe Cys Phe Ser 
1               5                   10                  15      


Val Lys Gly His Val Lys Met Leu Arg Leu Asp Ile Ile Asn Ser Leu 
            20                  25                  30          


Val Thr Thr Val Phe Met Leu Ile Val Ser Val Leu Ala Leu Ile Pro 
        35                  40                  45              


Glu Thr Thr Thr Leu Thr Val Gly Gly Gly Val Phe Ala Leu Val Thr 
    50                  55                  60                  


Ala Val Cys Cys Leu Ala Asp Gly Ala Leu Ile Tyr Arg Lys Leu Leu 
65                  70                  75                  80  


Phe Asn Pro Ser Gly Pro Tyr Gln Lys Lys Pro Val His Glu Lys Lys 
                85                  90                  95      


Glu Val Leu 
            


<210>  6615
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  6615

Met Asp Asn Val Gln Pro Lys Ile Lys His Arg Pro Phe Cys Phe Ser 
1               5                   10                  15      


Val Lys Gly His Val Lys Met Leu Arg Leu Ala Leu Thr Val Thr Ser 
            20                  25                  30          


Met Thr Phe Phe Ile Ile Ala Gln Ala Pro Glu Pro Tyr Ile Val Ile 
        35                  40                  45              


Thr Gly Phe Glu Val Thr Val Ile Leu Phe Phe Ile Leu Leu Tyr Val 
    50                  55                  60                  


Leu Arg Leu Asp Arg Leu Met Lys Trp Leu Phe Trp Pro Leu Leu Val 
65                  70                  75                  80  


Phe Ala Leu Val Thr Ala Val Cys Cys Leu Ala Asp Gly Ala Leu Ile 
                85                  90                  95      


Tyr Arg Lys Leu Leu Phe Asn Pro Ser Gly Pro Tyr Gln Lys Lys Pro 
            100                 105                 110         


Val His Glu Lys Lys Glu Val Leu 
        115                 120 


<210>  6616
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  6616

Met Ala Pro Ala Arg Thr Met Ala Arg Ala Arg Leu Ala Pro Ala Gly 
1               5                   10                  15      


Ile Pro Ala Val Ala Leu Trp Leu Leu Cys Thr Leu Gly Leu Gln Gly 
            20                  25                  30          


Thr Gln Ala Gly Pro Pro Pro Ala Pro Pro Gly Leu Pro Ala Gly Ala 
        35                  40                  45              


Asp Cys Leu Asn Ser Phe Thr Ala Gly Val Pro Gly Phe Val Leu Asp 
    50                  55                  60                  


Thr Asn Ala Ser Val Ser Asn Gly Ala Thr Phe Leu Glu Ser Pro Thr 
65                  70                  75                  80  


Val Arg Arg Gly Trp Asp Cys Val Arg Ala Cys Cys Thr Thr Gln Asn 
                85                  90                  95      


Cys Asn Leu Ala Leu Val Glu Leu Gln Pro Asp Arg Gly Glu Asp Ala 
            100                 105                 110         


Ile Ala Ala Cys Phe Leu Ile Asn Cys Leu Tyr Glu Gln Asn Phe Val 
        115                 120                 125             


Cys Lys Phe Ala Pro Arg Glu Gly Phe Ile Asn Tyr Leu Thr Arg Glu 
    130                 135                 140                 


Val Tyr Arg Ser Tyr Arg Gln Leu Arg Thr Gln Gly Phe Gly Gly Ser 
145                 150                 155                 160 


Gly Ile Pro Lys Ala Trp Ala Gly Ile Asp Leu Lys Val Gln Pro Gln 
                165                 170                 175     


Glu Pro Leu Val Leu Lys Asp Val Glu Asn Thr Asp Trp Arg Leu Leu 
            180                 185                 190         


Arg Gly Asp Thr Asp Val Arg Val Glu Arg Lys Asp Pro Asn Gln Val 
        195                 200                 205             


Glu Leu Trp Gly Leu Lys Glu Gly Thr Tyr Leu Phe Gln Leu Thr Val 
    210                 215                 220                 


Thr Ser Ser Asp His Pro Glu Asp Thr Ala Asn Val Thr Val Thr Val 
225                 230                 235                 240 


Leu Ser Thr Lys Gln Thr Glu Asp Tyr Cys Leu Ala Ser Asn Lys Val 
                245                 250                 255     


Gly Arg Cys Arg Gly Ser Phe Pro Arg Trp Tyr Tyr Asp Pro Thr Glu 
            260                 265                 270         


Gln Ile Cys Lys Ser Phe Val Tyr Gly Gly Cys Leu Gly Asn Lys Asn 
        275                 280                 285             


Asn Tyr Leu Arg Glu Glu Glu Cys Ile Leu Ala Cys Arg Gly Val Gln 
    290                 295                 300                 


Gly Gly Pro Leu Arg Gly Ser Ser Gly Ala Gln Ala Thr Phe Pro Gln 
305                 310                 315                 320 


Gly Pro Ser Met Glu Arg Arg His Pro Val Cys Ser Gly Thr Cys Gln 
                325                 330                 335     


Pro Thr Gln Phe Arg Cys Ser Asn Gly Cys Cys Ile Asp Ser Phe Leu 
            340                 345                 350         


Glu Cys Asp Asp Thr Pro Asn Cys Pro Asp Ala Ser Asp Glu Ala Ala 
        355                 360                 365             


Cys Glu Lys Tyr Thr Ser Gly Phe Asp Glu Leu Gln Arg Ile His Phe 
    370                 375                 380                 


Pro Ser Asp Lys Gly His Cys Val Asp Leu Pro Asp Thr Gly Leu Cys 
385                 390                 395                 400 


Lys Glu Ser Ile Pro Arg Trp Tyr Tyr Asn Pro Phe Ser Glu His Cys 
                405                 410                 415     


Ala Arg Phe Thr Tyr Gly Gly Cys Tyr Gly Asn Lys Asn Asn Phe Glu 
            420                 425                 430         


Glu Glu Gln Gln Cys Leu Glu Ser Cys Arg Gly Ile Ser Lys Lys Asp 
        435                 440                 445             


Val Phe Gly Leu Arg Arg Glu Ile Pro Ile Pro Ser Thr Gly Ser Val 
    450                 455                 460                 


Glu Met Ala Val Ala Val Phe Leu Val Ile Cys Ile Val Val Val Val 
465                 470                 475                 480 


Ala Ile Leu Gly Tyr Cys Phe Phe Lys Asn Gln Arg Lys Asp Phe His 
                485                 490                 495     


Gly His His His His Pro Pro Pro Thr Pro Ala Ser Ser Thr Val Ser 
            500                 505                 510         


Thr Thr Glu Asp Thr Glu His Leu Val Tyr Asn His Thr Thr Arg Pro 
        515                 520                 525             


Leu 
    


<210>  6617
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  6617

Met Gly Cys Asp Gly Arg Val Ser Gly Leu Leu Arg Arg Asn Leu Gln 
1               5                   10                  15      


Pro Thr Leu Thr Tyr Trp Ser Val Phe Phe Ser Phe Gly Leu Cys Ile 
            20                  25                  30          


Ala Phe Leu Gly Pro Thr Leu Leu Asp Leu Arg Cys Gln Thr His Ser 
        35                  40                  45              


Ser Leu Pro Gln Ile Ser Trp Val Phe Phe Ser Gln Gln Leu Cys Leu 
    50                  55                  60                  


Leu Leu Gly Ser Ala Leu Gly Gly Val Phe Lys Arg Thr Leu Ala Gln 
65                  70                  75                  80  


Ser Leu Trp Ala Leu Phe Thr Ser Ser Leu Ala Ile Ser Leu Val Phe 
                85                  90                  95      


Ala Val Ile Pro Phe Cys Arg Asp Val Lys Val Leu Ala Ser Val Met 
            100                 105                 110         


Ala Leu Ala Gly Leu Ala Met Gly Cys Ile Asp Thr Val Ala Asn Met 
        115                 120                 125             


Gln Leu Val Arg Met Tyr Gln Lys Asp Ser Ala Val Phe Leu Gln Val 
    130                 135                 140                 


Leu His Phe Phe Val Gly Phe Gly Ala Leu Leu Ser Pro Leu Ile Ala 
145                 150                 155                 160 


Asp Pro Phe Leu Ser Glu Ala Asn Cys Leu Pro Ala Asn Ser Thr Ala 
                165                 170                 175     


Asn Thr Thr Ser Arg Gly His Leu Phe His Val Ser Arg Val Leu Gly 
            180                 185                 190         


Gln His His Val Asp Ala Lys Pro Trp Ser Asn Gln Thr Phe Pro Gly 
        195                 200                 205             


Leu Thr Pro Lys Asp Gly Ala Gly Thr Arg Val Ser Tyr Ala Phe Trp 
    210                 215                 220                 


Ile Met Ala Leu Ile Asn Leu Pro Val Pro Met Ala Val Leu Met Leu 
225                 230                 235                 240 


Leu Ser Lys Glu Arg Leu Leu Thr Cys Cys Pro Gln Arg Arg Pro Leu 
                245                 250                 255     


Leu Leu Ser Ala Asp Glu Leu Ala Leu Glu Thr Gln Pro Pro Glu Lys 
            260                 265                 270         


Glu Asp Ala Ser Ser Leu Pro Pro Lys Phe Gln Ser His Leu Gly His 
        275                 280                 285             


Glu Asp Leu Phe Ser Cys Cys Gln Arg Lys Asn Leu Arg Gly Ala Pro 
    290                 295                 300                 


Tyr Ser Phe Phe Ala Ile His Ile Thr Gly Ala Leu Val Leu Phe Met 
305                 310                 315                 320 


Thr Asp Gly Leu Thr Gly Ala Tyr Ser Ala Phe Val Tyr Ser Tyr Ala 
                325                 330                 335     


Val Glu Lys Pro Leu Ser Val Gly His Lys Val Ala Gly Tyr Leu Pro 
            340                 345                 350         


Ser Leu Phe Trp Gly Phe Ile Thr Leu Gly Arg Leu Leu Ser Ile Pro 
        355                 360                 365             


Ile Ser Ser Arg Met Lys Pro Ala Thr Met Val Phe Ile Asn Val Val 
    370                 375                 380                 


Gly Val Val Val Thr Phe Leu Val Leu Leu Ile Phe Ser Tyr Asn Val 
385                 390                 395                 400 


Val Phe Leu Phe Val Gly Thr Ala Ser Leu Gly Leu Phe Leu Ser Ser 
                405                 410                 415     


Thr Phe Pro Ser Met Leu Ala Tyr Thr Glu Asp Ser Leu Gln Tyr Lys 
            420                 425                 430         


Gly Cys Ala Thr Thr Val Leu Val Thr Gly Ala Gly Val Gly Glu Met 
        435                 440                 445             


Val Leu Gln Met Leu Val Gly Ser Ile Phe Gln Ala Gln Gly Ser Tyr 
    450                 455                 460                 


Ser Phe Leu Val Cys Gly Val Ile Phe Gly Cys Leu Ala Phe Thr Phe 
465                 470                 475                 480 


Tyr Ile Leu Leu Leu Phe Phe His Arg Met His Pro Gly Leu Pro Ser 
                485                 490                 495     


Val Pro Thr Gln Asp Arg Ser Ile Gly Met Glu Asn Ser Glu Cys Tyr 
            500                 505                 510         


Gln Arg 
        


<210>  6618
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  6618

Met Glu Asn Gln Ala His Asn Thr Met Gly Thr Ser Pro Cys Glu Ala 
1               5                   10                  15      


Glu Leu Gln Glu Leu Met Glu Gln Ile Asp Ile Met Val Ser Asn Lys 
            20                  25                  30          


Lys Met Asp Trp Glu Arg Lys Met Arg Ala Leu Glu Thr Arg Leu Asp 
        35                  40                  45              


Leu Arg Asp Gln Glu Leu Ala Asn Ala Gln Thr Cys Leu Asp Gln Lys 
    50                  55                  60                  


Gly Gln Glu Val Gly Leu Leu Arg Gln Lys Leu Asp Ser Leu Glu Lys 
65                  70                  75                  80  


Cys Asn Leu Ala Met Thr Gln Asn Tyr Glu Gly Gln Leu Gln Ser Leu 
                85                  90                  95      


Lys Ala Gln Phe Ser Lys Leu Thr Asn Asn Phe Glu Lys Leu Arg Leu 
            100                 105                 110         


His Gln Met Lys Gln Asn Lys Val Pro Arg Lys Glu Leu Pro His Leu 
        115                 120                 125             


Lys Glu Glu Ile Pro Phe Glu Leu Ser Asn Leu Asn Gln Lys Leu Glu 
    130                 135                 140                 


Glu Phe Arg Ala Lys Ser Arg Glu Trp Asp Lys Gln Glu Ile Leu Tyr 
145                 150                 155                 160 


Gln Thr His Leu Ile Ser Leu Asp Ala Gln Gln Lys Leu Leu Ser Glu 
                165                 170                 175     


Lys Cys Asn Gln Phe Gln Lys Gln Ala Gln Ser Tyr Gln Thr Gln Leu 
            180                 185                 190         


Asn Gly Lys Lys Gln Cys Leu Glu Asp Ser Ser Ser Glu Ile Pro Arg 
        195                 200                 205             


Leu Ile Cys Asp Pro Asp Pro Asn Cys Glu Ile Asn Glu Arg Asp Glu 
    210                 215                 220                 


Phe Ile Ile Glu Lys Leu Lys Ser Ala Val Asn Glu Ile Ala Leu Ser 
225                 230                 235                 240 


Arg Asn Lys Leu Gln Asp Glu Asn Gln Lys Leu Leu Gln Glu Leu Lys 
                245                 250                 255     


Met Tyr Gln Arg Gln Cys Gln Ala Met Glu Ala Gly Leu Ser Glu Val 
            260                 265                 270         


Lys Ser Glu Leu Gln Ser Arg Asp Asp Leu Leu Arg Ile Ile Glu Met 
        275                 280                 285             


Glu Arg Leu Gln Leu His Arg Glu Leu Leu Lys Ile Gly Glu Cys Gln 
    290                 295                 300                 


Asn Ala Gln Gly Asn Lys Thr Arg Leu Glu Ser Ser Tyr Leu Pro Ser 
305                 310                 315                 320 


Ile Lys Glu Pro Glu Arg Lys Ile Lys Glu Leu Phe Ser Val Met Gln 
                325                 330                 335     


Asp Gln Pro Asn His Glu Lys Glu Leu Asn Lys Ile Arg Ser Gln Leu 
            340                 345                 350         


Gln Gln Val Glu Glu Tyr His Asn Ser Glu Gln Glu Arg Met Arg Asn 
        355                 360                 365             


Glu Ile Ser Asp Leu Thr Glu Glu Leu His Gln Lys Glu Ile Thr Ile 
    370                 375                 380                 


Ala Thr Val Thr Lys Lys Ala Ala Leu Leu Glu Lys Gln Leu Lys Met 
385                 390                 395                 400 


Glu Leu Glu Ile Lys Glu Lys Met Leu Ala Lys Gln Lys Val Ser Asp 
                405                 410                 415     


Met Lys Tyr Lys Ala Val Arg Thr Glu Asn Thr His Leu Lys Gly Met 
            420                 425                 430         


Met Gly Asp Leu Asp Pro Gly Glu Tyr Met Ser Met Asp Phe Thr Asn 
        435                 440                 445             


Arg Glu Gln Ser Arg His Thr Ser Ile Asn Lys Leu Gln Tyr Glu Asn 
    450                 455                 460                 


Glu Arg Leu Arg Asn Asp Leu Ala Lys Leu His Val Asn Gly Lys Ser 
465                 470                 475                 480 


Thr Trp Thr Asn Gln Asn Thr Tyr Glu Glu Thr Gly Arg Tyr Ala Tyr 
                485                 490                 495     


Gln Ser Gln Ile Lys Val Glu Gln Asn Glu Glu Arg Leu Ser His Asp 
            500                 505                 510         


Cys Glu Pro Asn Arg Ser Thr Met Pro Pro Leu Pro Pro Ser Thr Phe 
        515                 520                 525             


Gln Ala Lys Glu Met Thr Ser Pro Leu Val Ser Asp Asp Asp Val Phe 
    530                 535                 540                 


Pro Leu Ser Pro Pro Asp Met Ser Phe Pro Ala Ser Leu Ala Ala Gln 
545                 550                 555                 560 


His Phe Leu Leu Glu Glu Glu Lys Arg Ala Lys Glu Leu Glu Lys Leu 
                565                 570                 575     


Leu Asn Thr His Ile Asp Glu Leu Gln Arg His Thr Glu Phe Thr Leu 
            580                 585                 590         


Asn Lys Tyr Ser Lys Leu Lys Gln Asn Arg His Ile 
        595                 600                 


<210>  6619
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  6619

Met Asn Thr Thr Ser Ser Ala Ala Pro Pro Ser Leu Gly Val Glu Phe 
1               5                   10                  15      


Ile Ser Leu Leu Ala Ile Ile Leu Leu Ser Val Ala Leu Ala Val Gly 
            20                  25                  30          


Leu Pro Gly Asn Ser Phe Val Val Trp Ser Ile Leu Lys Arg Met Gln 
        35                  40                  45              


Lys Arg Ser Val Thr Ala Leu Met Val Leu Asn Leu Ala Leu Ala Asp 
    50                  55                  60                  


Leu Ala Val Leu Leu Thr Ala Pro Phe Phe Leu His Phe Leu Ala Gln 
65                  70                  75                  80  


Gly Thr Trp Ser Phe Gly Leu Ala Gly Cys Arg Leu Cys His Tyr Val 
                85                  90                  95      


Cys Gly Val Ser Met Tyr Ala Ser Val Leu Leu Ile Thr Ala Met Ser 
            100                 105                 110         


Leu Asp Arg Ser Leu Ala Val Ala Arg Pro Phe Val Ser Gln Lys Leu 
        115                 120                 125             


Arg Thr Lys Ala Met Ala Arg Arg Val Leu Ala Gly Ile Trp Val Leu 
    130                 135                 140                 


Ser Phe Leu Leu Ala Thr Pro Val Leu Ala Tyr Arg Thr Val Val Pro 
145                 150                 155                 160 


Trp Lys Thr Asn Met Ser Leu Cys Phe Pro Arg Tyr Pro Ser Glu Gly 
                165                 170                 175     


His Arg Ala Phe His Leu Ile Phe Glu Ala Val Thr Gly Phe Leu Leu 
            180                 185                 190         


Pro Phe Leu Ala Val Val Ala Ser Tyr Ser Asp Ile Gly Arg Arg Leu 
        195                 200                 205             


Gln Ala Arg Arg Phe Arg Arg Ser Arg Arg Thr Gly Arg Leu Val Val 
    210                 215                 220                 


Leu Ile Ile Leu Thr Phe Ala Ala Phe Trp Leu Pro Tyr His Val Val 
225                 230                 235                 240 


Asn Leu Ala Glu Ala Gly Arg Ala Leu Ala Gly Gln Ala Ala Gly Leu 
                245                 250                 255     


Gly Leu Val Gly Lys Arg Leu Ser Leu Ala Arg Asn Val Leu Ile Ala 
            260                 265                 270         


Leu Ala Phe Leu Ser Ser Ser Val Asn Pro Val Leu Tyr Ala Cys Ala 
        275                 280                 285             


Gly Gly Gly Leu Leu Arg Ser Ala Gly Val Gly Phe Val Ala Lys Leu 
    290                 295                 300                 


Leu Glu Gly Thr Gly Ser Glu Ala Ser Ser Thr Arg Arg Gly Gly Ser 
305                 310                 315                 320 


Leu Gly Gln Thr Ala Arg Ser Gly Pro Ala Ala Leu Glu Pro Gly Pro 
                325                 330                 335     


Ser Glu Ser Leu Thr Ala Ser Ser Pro Leu Lys Leu Asn Glu Leu Asn 
            340                 345                 350         


<210>  6620
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  6620

Met Ala Ala Val Ala Ala Ala Ser Ala Glu Leu Leu Ile Ile Gly Trp 
1               5                   10                  15      


Tyr Ile Phe Arg Val Leu Leu Gln Val Phe Arg Tyr Ser Leu Gln Lys 
            20                  25                  30          


Leu Ala Tyr Thr Val Ser Arg Thr Gly Arg Gln Val Leu Gly Glu Arg 
        35                  40                  45              


Arg Gln Arg Ala Pro Asn 
    50                  


<210>  6621
<211>  698
<212>  PRT
<213>  Homo sapiens

<400>  6621

Met Ala Ala Ala Gly Ala Ala Val Ala Arg Ser Pro Gly Ile Gly Ala 
1               5                   10                  15      


Gly Pro Ala Leu Arg Ala Arg Arg Ser Pro Pro Pro Arg Ala Ala Arg 
            20                  25                  30          


Leu Pro Arg Leu Leu Val Leu Leu Ala Ala Ala Ala Val Gly Pro Gly 
        35                  40                  45              


Ala Gly Gly Ala Ala Arg Leu Tyr Arg Ala Gly Glu Asp Ala Val Trp 
    50                  55                  60                  


Val Leu Asp Ser Gly Ser Val Arg Gly Ala Thr Ala Asn Ser Ser Ala 
65                  70                  75                  80  


Ala Trp Leu Val Gln Phe Tyr Ser Ser Trp Cys Gly His Cys Ile Gly 
                85                  90                  95      


Tyr Ala Pro Thr Trp Arg Ala Leu Ala Gly Asp Val Arg Asp Trp Ala 
            100                 105                 110         


Ser Ala Ile Arg Val Ala Ala Leu Asp Cys Met Glu Glu Lys Asn Gln 
        115                 120                 125             


Ala Val Cys His Asp Tyr Asp Ile His Phe Tyr Pro Thr Phe Arg Tyr 
    130                 135                 140                 


Phe Lys Ala Phe Thr Lys Glu Phe Thr Thr Gly Glu Asn Phe Lys Gly 
145                 150                 155                 160 


Pro Asp Arg Glu Leu Arg Thr Val Arg Gln Thr Met Ile Asp Phe Leu 
                165                 170                 175     


Gln Asn His Thr Glu Gly Ser Arg Pro Pro Ala Cys Pro Arg Leu Asp 
            180                 185                 190         


Pro Ile Gln Pro Ser Asp Val Leu Ser Leu Leu Asp Asn Arg Gly Ser 
        195                 200                 205             


His Tyr Val Ala Ile Val Phe Glu Ser Asn Ser Ser Tyr Leu Gly Arg 
    210                 215                 220                 


Glu Val Ile Leu Asp Leu Ile Pro Tyr Glu Ser Ile Val Val Thr Arg 
225                 230                 235                 240 


Ala Leu Asp Gly Asp Lys Ala Phe Leu Glu Lys Leu Gly Val Ser Ser 
                245                 250                 255     


Val Pro Ser Cys Tyr Leu Ile Tyr Pro Asn Gly Ser His Gly Leu Ile 
            260                 265                 270         


Asn Val Val Lys Pro Leu Arg Ala Phe Phe Ser Ser Tyr Leu Lys Ser 
        275                 280                 285             


Leu Pro Asp Val Arg Lys Lys Ser Leu Pro Leu Pro Glu Lys Pro His 
    290                 295                 300                 


Lys Glu Glu Asn Ser Glu Ile Val Val Trp Arg Glu Phe Asp Lys Ser 
305                 310                 315                 320 


Lys Leu Tyr Thr Val Asp Leu Glu Ser Gly Leu His Tyr Leu Leu Arg 
                325                 330                 335     


Val Glu Leu Ala Ala His Lys Ser Leu Ala Gly Ala Glu Leu Lys Thr 
            340                 345                 350         


Leu Lys Asp Phe Val Thr Val Leu Ala Lys Leu Phe Pro Gly Arg Pro 
        355                 360                 365             


Pro Val Lys Lys Leu Leu Glu Met Leu Gln Glu Trp Leu Ala Ser Leu 
    370                 375                 380                 


Pro Leu Asp Arg Ile Pro Tyr Asn Ala Val Leu Asp Leu Val Asn Asn 
385                 390                 395                 400 


Lys Met Arg Ile Ser Gly Ile Phe Leu Thr Asn His Ile Lys Trp Val 
                405                 410                 415     


Gly Cys Gln Gly Ser Arg Ser Glu Leu Arg Gly Tyr Pro Cys Ser Leu 
            420                 425                 430         


Trp Lys Leu Phe His Thr Leu Thr Val Glu Ala Ser Thr His Pro Asp 
        435                 440                 445             


Ala Leu Val Gly Thr Gly Phe Glu Asp Asp Pro Gln Ala Val Leu Gln 
    450                 455                 460                 


Thr Met Arg Arg Tyr Val His Thr Phe Phe Gly Cys Lys Glu Cys Gly 
465                 470                 475                 480 


Glu His Phe Glu Glu Met Ala Lys Glu Ser Met Asp Ser Val Lys Thr 
                485                 490                 495     


Pro Asp Gln Ala Ile Leu Trp Leu Trp Lys Lys His Asn Met Val Asn 
            500                 505                 510         


Gly Arg Leu Ala Gly His Leu Ser Glu Asp Pro Arg Phe Pro Lys Leu 
        515                 520                 525             


Gln Trp Pro Thr Pro Asp Leu Cys Pro Ala Cys His Glu Glu Ile Lys 
    530                 535                 540                 


Gly Leu Ala Ser Trp Asp Glu Gly His Val Leu Thr Phe Leu Lys Gln 
545                 550                 555                 560 


His Tyr Gly Arg Asp Asn Leu Leu Asp Thr Tyr Ser Ala Asp Gln Gly 
                565                 570                 575     


Asp Ser Ser Glu Gly Gly Thr Leu Ala Arg Gly Glu Glu Glu Glu Lys 
            580                 585                 590         


Arg Leu Thr Pro Pro Glu Val Ser His Gly Asp Arg Asp Thr Gln Ser 
        595                 600                 605             


Val Arg Pro Pro Gly Ala Leu Gly Pro Arg Pro Ala Leu Pro Glu Ser 
    610                 615                 620                 


Leu His His Ser Leu Asp Gly Lys Leu Gln Ser Leu Asp Gly Pro Gly 
625                 630                 635                 640 


Ala His Lys Glu Val Gly Gly Ala Ala Pro Phe Leu Gly Val Asp Phe 
                645                 650                 655     


Ser Ser Leu Asp Met Ser Leu Cys Val Val Leu Tyr Val Ala Ser Ser 
            660                 665                 670         


Leu Phe Leu Met Val Met Tyr Phe Phe Phe Arg Val Arg Ser Arg Arg 
        675                 680                 685             


Trp Lys Val Lys His His His Pro Ala Val 
    690                 695             


<210>  6622
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  6622

Met Gly Asp Trp Ser Phe Leu Gly Asn Phe Leu Glu Glu Val His Lys 
1               5                   10                  15      


His Ser Thr Val Val Gly Lys Val Trp Leu Thr Val Leu Phe Ile Phe 
            20                  25                  30          


Arg Met Leu Val Leu Gly Thr Ala Ala Glu Ser Ser Trp Gly Asp Glu 
        35                  40                  45              


Gln Ala Asp Phe Arg Cys Asp Thr Ile Gln Pro Gly Cys Gln Asn Val 
    50                  55                  60                  


Cys Tyr Asp Gln Ala Phe Pro Ile Ser His Ile Arg Tyr Trp Val Leu 
65                  70                  75                  80  


Gln Ile Ile Phe Val Ser Thr Pro Ser Leu Val Tyr Met Gly His Ala 
                85                  90                  95      


Met His Thr Val Arg Met Gln Glu Lys Arg Lys Leu Arg Glu Ala Glu 
            100                 105                 110         


Arg Ala Lys Glu Val Arg Gly Ser Gly Ser Tyr Glu Tyr Pro Val Ala 
        115                 120                 125             


Glu Lys Ala Glu Leu Ser Cys Trp Glu Glu Gly Asn Gly Arg Ile Ala 
    130                 135                 140                 


Leu Gln Gly Thr Leu Leu Asn Thr Tyr Val Cys Ser Ile Leu Ile Arg 
145                 150                 155                 160 


Thr Thr Met Glu Val Gly Phe Ile Val Gly Gln Tyr Phe Ile Tyr Gly 
                165                 170                 175     


Ile Phe Leu Thr Thr Leu His Val Cys Arg Arg Ser Pro Cys Pro His 
            180                 185                 190         


Pro Val Asn Cys Tyr Val Ser Arg Pro Thr Glu Lys Asn Val Phe Ile 
        195                 200                 205             


Val Phe Met Leu Ala Val Ala Ala Leu Ser Leu Leu Leu Ser Leu Ala 
    210                 215                 220                 


Glu Leu Tyr His Leu Gly Trp Lys Lys Ile Arg Gln Arg Phe Val Lys 
225                 230                 235                 240 


Pro Arg Gln His Met Ala Lys Cys Gln Leu Ser Gly Pro Ser Val Gly 
                245   